{"token": ["Signaling", "lymphocytic", "activating", "molecule", "(", "SLAM", ")", "C3539787#ent", "<e1>", ")", "is", "a", "C0072522#ent", "<e2>", "that", "belongs", "to", "the", "CD2", "subset", "the", "immunoglobulin", "superfamily", "is", "expressed", "on", "the", "surface", "of", "activated", "T-", "and", "B-cells", "."], "h": {"id": "C3539787", "name": "C3539787#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}}
{"token": ["CNQX", ",", "APV", ",", "bicuculline", ",", "CGP35348", "(", "C0242975#ent", "<e1>", ",", "promethazine", ",", "atropine", ",", "C0041345#ent", "<e2>", "and", "suramin", "had", "no", "obvious", "effects", "on", "oscillatory", "bursting", "."], "h": {"id": "C0242975", "name": "C0242975#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041345", "name": "C0041345#ent", "pos": [15, 16]}}
{"token": ["The", "rank", "order", "of", "agonist", "potency", "was", "C0282210#ent", "<e1>", "greater", "than", "norepinephrine", "greater", "than", "epinephrine", "greater", "than", "C0072032#ent", "<e2>", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072032", "name": "C0072032#ent", "pos": [17, 18]}}
{"token": ["The", "bronchodilating", "effect", "other", "related", "pharmacological", "properties", "of", "SN-408", "were", "studied", "in", "comparison", "with", "those", "of", "C0282210#ent", "<e1>", ",", "salbutamol", "and", "C0072032#ent", "<e2>", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0072032", "name": "C0072032#ent", "pos": [21, 22]}}
{"token": ["C0282210#ent", "<e1>", ",", "denopamine", ",", "and", "C0072032#ent", "<e2>", "stimulated", "lipolysis", "with", "EC50", "values", "of", "4,500", ",", "and", "83", "nmol/L", ",", "respectively", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072032", "name": "C0072032#ent", "pos": [6, 7]}}
{"token": ["Our", "observations", "indicate", "that", "C0032969#ent", "<e1>", "Mexican-American", "women", "have", "predominantly", "GDM", "and", "C0011860#ent", "<e2>"], "h": {"id": "C0032969", "name": "C0032969#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}}
{"token": ["Immunohistochemistry", "demonstrated", "that", "a", "few", "adenoma", "cells", "positive", "for", "C1418938#ent", "<e1>", "and", "the", "cyst", "wall", "cells", "positive", "for", "C1416713#ent", "<e2>", "and", "negative", "for", "S-100", "protein"], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416713", "name": "C1416713#ent", "pos": [18, 19]}}
{"token": ["A", "38-year-old", "woman", "developed", "C0235299#ent", "<e1>", "to", "a", "mass", "in", "the", "left", "lobe", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C0235299", "name": "C0235299#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [14, 15]}}
{"token": ["Compared", "with", "responders", "and", "healthy", "controls", "newly", "diagnosed", "patients", "and", "nonresponders", "had", "slight", "diminutions", "in", "LDH-1", "and", "C2745793#ent", "<e1>", ",", "but", "increased", "C0236559#ent", "<e2>", "."], "h": {"id": "C2745793", "name": "C2745793#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0236559", "name": "C0236559#ent", "pos": [22, 23]}}
{"token": ["The", "result", "indicates", "that", "C1418938#ent", "<e1>", "immunoreactivity", "is", "well-developed", "in", "the", "plerocercoid", "of", "the", "C0007894#ent", "<e2>", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007894", "name": "C0007894#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "suggest", "that", "C0011849#ent", "<e1>", "medication", "with", "C0724709#ent", "<e2>", "should", "be", "carefully", "performed", "in", "patients", "receiving", "dialysis", "treatment", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [8, 9]}}
{"token": ["Thus", "mortality", "rates", "increased", "in", "persons", "with", "impaired", "glucose", "tolerance", "C0011849#ent", "<e1>", ",", "and", "the", "small", "clinical", "trial", "that", "C0724709#ent", "<e2>", "may", "be", "beneficial", "in", "men", "with", "abnormal", "glucose", "tolerance"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "intake", "of", "potassium", "salts", "21", "-", "28", "days", "on", "the", "glucose", "tolerance", "10", "elderly", "subjects", "clear", "C0011849#ent", "<e1>", "were", "examined", "by", "means", "of", "the", "C0724709#ent", "<e2>", "TT", ")", "and", "the", "i.v", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [27, 28]}}
{"token": ["The", "possible", "use", "of", "C0035542#ent", "<e1>", "as", "a", "C0304402#ent", "<e2>", "of", "the", "growth", "of", "industrial", "strains", "demonstrated", "which", "is", "advantageous", "for", "colonization", "of", "the", "biological", "surfaces", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [8, 9]}}
{"token": ["The", "C0032594#ent", "<e1>", "has", "no", "effect", "the", "activity", "of", "C0599208#ent", "<e2>", "stimulated", "by", "limited", "proteolysis", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599208", "name": "C0599208#ent", "pos": [9, 10]}}
{"token": ["Bone", "marrow", "colonies", "patients", "who", "had", "recovered", "from", "neutropenia", "induced", "by", "C0018034#ent", "<e1>", "not", "abnormally", "sensitive", "to", "the", "inhibitory", "effect", "of", "the", "C0013227#ent", "<e2>", "in", "vitro"], "h": {"id": "C0018034", "name": "C0018034#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [22, 23]}}
{"token": ["A", "patient", "with", "C0752120#ent", "<e1>", "had", "a", "prolonged", "central", "reflex", "time", "and", "a", "patient", "with", "C0085677#ent", "<e2>", "a", "delayed", "sudomotor", "potential", "."], "h": {"id": "C0752120", "name": "C0752120#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085677", "name": "C0085677#ent", "pos": [15, 16]}}
{"token": ["In", "these", "studies", "we", "examined", "the", "effects", "of", "C0019348#ent", "<e1>", "infection", "on", "HUVEC", "plasminogen", "activator", "inhibitor", "type", "1", "PAI-1", ")", "and", "tissue", "plasminogen", "activator", "C0032143#ent", "<e2>", ")", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [24, 25]}}
{"token": ["The", "underlying", "pathology", "was", "Gaucher's", "disease", "six", "patients", ",", "vitamin", "D-dependent", "rickets", "type", "II", "five", ",", "C0268579#ent", "<e1>", "two", ",", "and", "methylmalonic", "acidemia", "3-hydroxyl-3-methylglutaryl", "coenzyme", "A", "CoA", ")", "C0268601#ent", "<e2>", "fructose", "1,6", "diphosphatase", "deficiency", "and", "urea", "cycle", "disorder", "one", "child", "each", "."], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268601", "name": "C0268601#ent", "pos": [28, 29]}}
{"token": ["C0082608#ent", "<e1>", "provides", "a", "useful", "option", "in", "treating", "C0020443#ent", "<e2>", "in", "patients", "at", "high", "risk", "coronary", "heart", "disease"], "h": {"id": "C0082608", "name": "C0082608#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [8, 9]}}
{"token": ["The", "clinical", "efficacy", "tolerability", "of", "simvastatin", "and", "C0082608#ent", "<e1>", "were", "compared", "in", "432", "patients", "with", "C0020443#ent", "<e2>", "a", "multinational", ",", "randomised", ",", "double-blind", "trial"], "h": {"id": "C0082608", "name": "C0082608#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "in", "patients", "with", "C0156147#ent", "<e1>", "the", "high", "inducible", "C1705516#ent", "<e2>", "activity", "was", "not", "correlated", "with", "any", "intensity", "parameters", "of", "the", "disease", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705516", "name": "C1705516#ent", "pos": [11, 12]}}
{"token": ["We", "report", "the", "case", "of", "a", "56", "year", "old", "male", "with", "C0392514#ent", "<e1>", "by", "hepatic", "cirrhosis", "insulin", "treated", "diabetes", "mellitus", "hypogonadism", "and", "C3665349#ent", "<e2>", "the", "latter", "which", "was", "corrected", "by", "iron", "depletion", "."], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [22, 23]}}
{"token": ["A", "CE", "with", "LIF", "detection", "was", "developed", "for", "separation", "and", "determination", "of", "bradykinin", "(BK)-related", "C0030956#ent", "<e1>", ",", "such", "as", "BK", ",", "kallidin", "(", "C1418550#ent", "<e2>", ")", ",", "and", "neurokinin", "A", "NKA", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418550", "name": "C1418550#ent", "pos": [23, 24]}}
{"token": ["As", "a", "test", "for", "this", "system", ",", "we", "integrated", "the", "amy", "gene", "that", "codes", "for", "the", "C3853624#ent", "<e1>", "from", "B.", "stearothermophilus", "into", "the", "C0022959#ent", "<e2>", "E.", "coli", "."], "h": {"id": "C3853624", "name": "C3853624#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0022959", "name": "C0022959#ent", "pos": [23, 24]}}
{"token": ["Basal", "levels", "of", "thymosin", "beta", "4", "similar", "in", "normal", "women", "during", "the", "early", "follicular", "phase", "women", "with", "C0025322#ent", "<e1>", "postmenopausal", "women", "not", "receiving", "C2936882#ent", "<e2>", ",", "and", "individuals", "with", "gonadal", "dysgenesis"], "h": {"id": "C0025322", "name": "C0025322#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [23, 24]}}
{"token": ["When", "C4084845#ent", "<e1>", "was", "also", "inhibited", ",", "10", "nmol/l", "C0051570#ent", "<e2>", "caused", "84", "%", "inhibition", "of", "the", "deamination", "of", "noradrenaline", "by", "MAO-A", "in", "the", "lungs", "."], "h": {"id": "C4084845", "name": "C4084845#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0051570", "name": "C0051570#ent", "pos": [9, 10]}}
{"token": ["Neutrophils", "from", "patients", "with", "C0018203#ent", "<e1>", "which", "are", "C0056926#ent", "<e2>", "negative", "or", "have", "p47phox", "deficiency", ",", "exhibit", "no", "significant", "NADPH", "oxidase", "activity", "and", "show", "no", "increase", "in", "CL", "by", "sulfite", "."], "h": {"id": "C0018203", "name": "C0018203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0056926", "name": "C0056926#ent", "pos": [8, 9]}}
{"token": ["Activation", "with", "bacteria", "of", "neutrophilic", "granulocytes", "a", "patient", "with", "C0018203#ent", "<e1>", "that", "contain", "no", "C0056926#ent", "<e2>", "led", "to", "typical", "changes", "in", "the", "redox", "state", "myeloperoxidase", "."], "h": {"id": "C0018203", "name": "C0018203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0056926", "name": "C0056926#ent", "pos": [14, 15]}}
{"token": ["When", "the", "deacetylation", "of", "histones", "was", "inhibited", "by", "tricostatin", "A", "C2364020#ent", "<e1>", "mRNAs", "encoding", "several", "neuronal-specific", "genes", "such", "as", "SCG10", ",", "C1415298#ent", "<e2>", ",", "and", "choline", "acetyltransferase", "detectable", "."], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415298", "name": "C1415298#ent", "pos": [21, 22]}}
{"token": ["Although", "C0049289#ent", "<e1>", "may", "be", "the", "main", "component", "of", "limes", "responsible", "for", "C0521480#ent", "<e2>", ",", "dermatological", "interaction", "assays", "with", "psoralen", ",", "C0049289#ent", "<e1>", ",", "xanthotoxin", "and", "limettin", "should", "be", "conducted", "."], "h": {"id": "C0049289", "name": "C0049289#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0521480", "name": "C0521480#ent", "pos": [12, 13]}}
{"token": ["Peptido-leukotrienes", "are", "short-lived", "organic", "molecules", "to", "have", "potent", "biological", "effects", "C0127400#ent", "<e1>", "of", "inflammation", ",", "hypersensitivity", "and", "C0035242#ent", "<e2>"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [17, 18]}}
{"token": ["Human", "(", "h", ")", "airway", "smooth", "muscle", "ASM", ")", "cells", "are", "important", "C0127400#ent", "<e1>", "of", "the", "inflammatory", "process", "in", "asthma", "and", "other", "C0035242#ent", "<e2>"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [22, 23]}}
{"token": ["The", "effect", "of", "phenobarbital", "(", "PB", ")", ",", "beta-naphthoflavone", "(", "beta-NF", ")", "and", "rifampicin", "(", "C3890420#ent", "<e1>", ")", "on", "the", "drug-metabolizing", "activity", "of", "cultured", "squirrel", "monkey", "C0669372#ent", "<e2>", "was", "examined", "."], "h": {"id": "C3890420", "name": "C3890420#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [26, 27]}}
{"token": ["Northern", "and", "microarray", "analyses", "performed", "to", "assess", "the", "effect", "of", "loss", "of", "the", "C0808900#ent", "<e1>", "COOH", "terminus", "on", "transcriptional", "modulation", "C1860425#ent", "<e2>", "target", "genes", "."], "h": {"id": "C0808900", "name": "C0808900#ent", "pos": [13, 14]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1860425", "name": "C1860425#ent", "pos": [20, 21]}}
{"token": ["Co-transfection", "of", "C0808900#ent", "<e1>", "and", "the", "TGFBR2", "promoter", "induces", "promoter", "activity", "whereas", "C1860425#ent", "<e2>", "leads", "to", "suppression", "of", "TGFBR2", "promoter", "activity", "FLI1-induced", "promoter", "activity"], "h": {"id": "C0808900", "name": "C0808900#ent", "pos": [2, 3]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1860425", "name": "C1860425#ent", "pos": [12, 13]}}
{"token": ["The", "activity", "was", "maximal", "at", "pH", "6.0", "-", "7.0", ",", "inactivated", "almost", "completely", "by", "tosylphenylalanine", "chloromethyl", "ketone", "tosyllysine", "chloromethyl", "ketone", "leupeptin", ",", "antipain", ",", "and", "C0055676#ent", "<e1>", ",", "and", "dependent", "on", "C0012789#ent", "<e2>", "and", "mercaptoethanol", "."], "h": {"id": "C0055676", "name": "C0055676#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [31, 32]}}
{"token": ["Leupeptin", ",", "C0055676#ent", "<e1>", ",", "pepstatin", ",", "aprotinin", ",", "phenylmethylsulfonyl", "fluoride", "and", "C0012789#ent", "<e2>", "had", "no", "effect", "uCF", "."], "h": {"id": "C0055676", "name": "C0055676#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [12, 13]}}
{"token": ["Expression", "topography", "by", "in", "situ", "hybridization", "more", "intense", "labeling", "along", "the", "entire", "villus", "axis", "C3812649#ent", "<e1>", "and", "CT15", "compared", "with", "C1418768#ent", "<e2>", "and", "CT21", "."], "h": {"id": "C3812649", "name": "C3812649#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418768", "name": "C1418768#ent", "pos": [20, 21]}}
{"token": ["The", "photoluminescence", "of", "C0599532#ent", "<e1>", "capped", "CdS", "C1836075#ent", "<e2>", "was", "quenched", "by", "the", "nitroaromatic", "compounds"], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1836075", "name": "C1836075#ent", "pos": [7, 8]}}
{"token": ["Size", "tunability", "of", "C0599532#ent", "<e1>", "capped", "CdS", "nanoparticles", "(", "C1836075#ent", "<e2>", ")", "has", "been", "achieved", "by", "controlling", "the", "temperatures", "in", "situ"], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1836075", "name": "C1836075#ent", "pos": [9, 10]}}
{"token": ["The", "C0694897#ent", "<e1>", "tumor", "suppressor", "gene", "C1332010#ent", "<e2>", ")", "maps", "to", "chromosome", "3p25", "and", "somatic", "inactivation", "of", "the", "C0694897#ent", "<e1>", "gene", "occurs", "in", "up", "to", "70", "%", "of", "CC-RCC", "tumors", "and", "cell", "lines"], "h": {"id": "C1332010", "name": "C1332010#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0694897", "name": "C0694897#ent", "pos": [1, 2]}}
{"token": ["It", "is", "not", "known", "whether", "C0006230#ent", "<e1>", "treatment", "in", "C0001206#ent", "<e2>", "can", "be", "implemented", "for", "a", "life-long", "period", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [9, 10]}}
{"token": ["We", "did", "not", "show", "that", "glucagon", "suppressibility", "after", "OGTT", "was", "reestablished", "after", "treatment", "with", "C0006230#ent", "<e1>", "in", "non-diabetic", "and", "diabetic", "C0001206#ent", "<e2>", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [20, 21]}}
{"token": ["C4055463#ent", "<e1>", "HN", ")", "and", "C0020295#ent", "<e2>", "(", "HUN", ")", "are", "recognized", "more", "frequently", "as", "the", "routine", "use", "of", "prenatal", "ultrasonography", "increases", "."], "h": {"id": "C4055463", "name": "C4055463#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0020295", "name": "C0020295#ent", "pos": [5, 6]}}
{"token": ["Limited", "proteolysis", "by", "pancreatic", "elastase", "EC", "3.4.21.36", ")", "and", "chymotrypsin", "(", "C2606396#ent", "<e1>", "was", "used", "to", "study", "the", "domain", "structure", "active", "site", "beta-galactosidase", "(", "C0002245#ent", "<e2>", "(", "Escherichia", "coli", "."], "h": {"id": "C2606396", "name": "C2606396#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [24, 25]}}
{"token": ["Typically", ",", "recurrent", "episodes", "of", "Lyme", "borreliosis", "as", "erythema", "migrans", "but", "C0037285#ent", "<e1>", "like", "borrelial", "arthritis", "and", "C0025297#ent", "<e2>", ",", "have", "been", "described", "."], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [17, 18]}}
{"token": ["Neurologic", "involvement", "may", "occur", "with", "skin", "and", "C0037285#ent", "<e1>", "present", "alone", "as", "C0025297#ent", "<e2>", ",", "cranial", "neuritis", "and", "radiculopathy", "known", "as", "Bannwarth's", "syndrome"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [12, 13]}}
{"token": ["No", "significant", "were", "found", "between", "the", "frequencies", "of", "the", "TNF2", "C0002085#ent", "<e1>", "in", "Cypriot", "C0026269#ent", "<e2>", "patients", "and", "controls", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [14, 15]}}
{"token": ["Since", "gamma-aminobutyric", "acid", "modulates", "the", "release", "of", "prolactin", ",", "we", "examined", "the", "possible", "association", "between", "C0002085#ent", "<e1>", "of", "the", "GABRA3", "(", "gamma-aminobutyric", "acid", "A3", "receptor", "gene", "and", "C0026269#ent", "<e2>", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [27, 28]}}
{"token": ["A", "child", ",", "two", "months", "of", "age", ",", "suffering", "from", "cholestasis", "and", "C0023892#ent", "<e1>", "was", "found", "to", "be", "homozygous", "for", "C0221757#ent", "<e2>", "Pi", "type", "ZZ", "associated", "with", "degree", "extrahepatic", "bile", "duct", "obstruction", "."], "h": {"id": "C0023892", "name": "C0023892#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0221757", "name": "C0221757#ent", "pos": [20, 21]}}
{"token": ["In", "two", "matched", "groups", "of", "100", "each", ",", "and", "within", "the", "major", "C0277554#ent", "<e1>", "it", "was", "associated", "with", "acidosis", ",", "hypocalcaemia", "and", "C0085682#ent", "<e2>", "(", "as", "opposed", "to", "hyperphosphataemia", ")", "."], "h": {"id": "C0277554", "name": "C0277554#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085682", "name": "C0085682#ent", "pos": [22, 23]}}
{"token": ["In", "PE", ",", "the", "C0848332#ent", "<e1>", "of", "C1420851#ent", "<e2>", "and", "LMOX", "were", "observed", "as", "single", "C0848332#ent", "<e1>", "on", "the", "cathode", "and", "anode", "sides", ",", "respectively", "."], "h": {"id": "C1420851", "name": "C1420851#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0848332", "name": "C0848332#ent", "pos": [4, 5]}}
{"token": ["Ten", "schizophrenic", "inpatients", "were", "each", "treated", "with", "C0070470#ent", "<e1>", "PE", ")", "and", "C0070469#ent", "<e2>", "PD", ")", "."], "h": {"id": "C0070470", "name": "C0070470#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0070469", "name": "C0070469#ent", "pos": [12, 13]}}
{"token": ["Classical", "C0520463#ent", "<e1>", "results", "in", "excessive", "C3536949#ent", "<e2>", "production", "."], "h": {"id": "C0520463", "name": "C0520463#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [6, 7]}}
{"token": ["Enrichment", "attributable", "to", "C0034348#ent", "<e1>", "precursors", "was", "observed", "at", "C1", "and", "C6", "of", "the", "C0772162#ent", "<e2>", "as", "well", "as", "into", "the", "carboxylate", "group", "while", "scrambling", "of", "the", "label", "into", "C2", "was", "not", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0772162", "name": "C0772162#ent", "pos": [14, 15]}}
{"token": ["The", "alpha3", ",", "C1414429#ent", "<e1>", ",", "and", "beta4", "subunits", "are", "present", "in", "the", "C1423795#ent", "<e2>", "of", "sperm", "and", "possibly", "exist", "as", "alpha3alpha5beta4", "and/or", "alpha3beta4", "channels", "."], "h": {"id": "C1414429", "name": "C1414429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423795", "name": "C1423795#ent", "pos": [13, 14]}}
{"token": ["In", "the", "animal", "model", "humid", "air", "inhalation", ",", "procaterol", "and", "C0700580#ent", "<e1>", "completely", "prevented", "hyperventilation-induced", "bronchoconstriction", ",", "but", "C0010347#ent", "<e2>", "caused", "only", "partial", "prevention", "."], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010347", "name": "C0010347#ent", "pos": [18, 19]}}
{"token": ["Bronchodilation", "was", "noticed", "15", "minutes", "after", "the", "administration", "of", "salbutamol", "and", "C0700580#ent", "<e1>", "not", "after", "C0010347#ent", "<e2>", "or", "placebo", "."], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010347", "name": "C0010347#ent", "pos": [15, 16]}}
{"token": ["We", "have", "exploited", "this", "to", "study", "C1332409#ent", "<e1>", "mutants", "that", "are", "defective", "in", "repressing", "the", "C1857775#ent", "<e2>", "promoter", ",", "a", "complex", "naturally", "occurring", "promoter", "that", "is", "repressed", "by", "C1332409#ent", "<e1>", "."], "h": {"id": "C1332409", "name": "C1332409#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1857775", "name": "C1857775#ent", "pos": [15, 16]}}
{"token": ["In", "France", ",", "renal", "lesions", "more", "often", "due", "to", "C0016397#ent", "<e1>", "sinus", "or", "visceral", "abscesses", "with", "or", "without", "C0014118#ent", "<e2>", ",", "rather", "than", "to", "pharyngeal", "streptococcal", "infection"], "h": {"id": "C0016397", "name": "C0016397#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [18, 19]}}
{"token": ["These", "changes", "are", "consistent", "with", "benefits", "resulting", "from", "resolution", "of", "C0010054#ent", "<e1>", "well", "as", "from", "positive", "lusitropic", "effects", "C0005116#ent", "<e2>", "on", "the", "ventricular", "myocardium"], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0005116", "name": "C0005116#ent", "pos": [18, 19]}}
{"token": ["Twenty-six", "patients", "had", "classic", "C0684275#ent", "<e1>", "and", "one", "had", "C0008533#ent", "<e2>"], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [9, 10]}}
{"token": ["There", "were", "39", "C0684275#ent", "<e1>", "A", "or", "factor", "VIII", "deficiency", "patients", ",", "2", "C0008533#ent", "<e2>", "factor", "IX", "deficiency", "patients", "and", "1", "combined", "factor", "VIII", "and", "V", "deficiency", "patient", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [13, 14]}}
{"token": ["Western", "analyses", "that", "C1420433#ent", "<e1>", "expression", "is", "induced", "by", "1,25(OH)(2)D(3", ")", "treatment", "in", "C2987364#ent", "<e2>", "and", "p21(-/-", ")", "MEFs", "."], "h": {"id": "C1420433", "name": "C1420433#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}}
{"token": ["C1420433#ent", "<e1>", "is", "expressed", "throughout", "the", "C2987364#ent", "<e2>", "liver", ",", "but", "the", "related", "protein", "p21", "not", "detected", "."], "h": {"id": "C1420433", "name": "C1420433#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [6, 7]}}
{"token": ["Pituitary", "tumorigenesis", "accelerated", "in", "mice", "with", "severe", "TGF-beta", "resistance", ",", "and", "greatly", "accelerated", "in", "mice", "with", "TGF-beta", "resistance", "combined", "with", "decreased", "C1420433#ent", "<e1>", "expression", "compared", "with", "C2987364#ent", "<e2>"], "h": {"id": "C1420433", "name": "C1420433#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [26, 27]}}
{"token": ["Measurement", "of", "skin", "perfusion", "pressure", "(", "C1424276#ent", "<e1>", ")", "using", "laser", "Doppler", "become", "available", "for", "the", "assessment", "of", "C1704436#ent", "<e2>"], "h": {"id": "C1424276", "name": "C1424276#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [18, 19]}}
{"token": ["We", "studied", "whether", "measurements", "of", "C1424276#ent", "<e1>", "can", "be", "used", "to", "identify", "hemodialyzed", "patients", "with", "C1704436#ent", "<e2>", "comparing", "it", "with", "measurements", "of", "the", "ankle", "brachial", "pressure", "index", "ABI", ")", "."], "h": {"id": "C1424276", "name": "C1424276#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [15, 16]}}
{"token": ["C0399440#ent", "<e1>", "rapidly", "stimulated", "phosphatidylinositol", "3'-kinase", "C1705791#ent", "<e2>", ",", "p38", "mitogen-activated", "protein", "kinase", "and", "protein", "kinase", "C", "activities"], "h": {"id": "C0399440", "name": "C0399440#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [6, 7]}}
{"token": ["C0399440#ent", "<e1>", "treatment", "induced", "the", "phosphorylations", "of", "C1705791#ent", "<e2>", "and", "p38", "kinase", "time-", "and", "dose-", "dependent", "manners"], "h": {"id": "C0399440", "name": "C0399440#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [7, 8]}}
{"token": ["In", "MET-positive", "DLBCL", "cells", ",", "C0399440#ent", "<e1>", "induces", "MEK-dependent", "activation", "of", "C1705791#ent", "<e2>", "and", "PI3K-dependent", "phosphorylation", "of", "PKB", ",", "GSK3", ",", "and", "FOXO3a", "."], "h": {"id": "C0399440", "name": "C0399440#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [11, 12]}}
{"token": ["The", "C0015230#ent", "<e1>", "were", "scraped", "and", "extracted", "with", "C0008232#ent", "<e2>", "for", "spectrophotometric", "determination", "at", "523", "nm", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008232", "name": "C0008232#ent", "pos": [8, 9]}}
{"token": ["The", "uterine", "uptake", "of", "C1412332#ent", "<e1>", "(", "67,000", "Da", ")", "and", "C3536873#ent", "<e2>", "150,000", "Da", ")", "were", "also", "measured", "for", "comparison", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536873", "name": "C3536873#ent", "pos": [11, 12]}}
{"token": ["C0770893#ent", "<e1>", "treatment", "had", "no", "significant", "impact", "on", "C4283740#ent", "<e2>", "expression", "in", "either", "adipocytes", "or", "skeletal", "muscle"], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [8, 9]}}
{"token": ["We", "show", "here", "that", "C1744370#ent", "<e1>", "and", "PTPBR7", "are", "isoforms", "derived", "from", "a", "single", "gene", "C1419123#ent", "<e2>", ")", "through", "developmentally", "regulated", "use", "of", "alternative", "promoters", "."], "h": {"id": "C1744370", "name": "C1744370#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419123", "name": "C1419123#ent", "pos": [15, 16]}}
{"token": ["A", "novel", "cDNA", "encoding", "PTP", "(", "protein", "tyrosine", "phosphatase", "was", "cloned", "from", "PC12h", "cells", "designated", "as", "C1744370#ent", "<e1>", "(", "gene", "encoding", "C1419123#ent", "<e2>", "."], "h": {"id": "C1744370", "name": "C1744370#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419123", "name": "C1419123#ent", "pos": [21, 22]}}
{"token": ["C0162836#ent", "<e1>", "a", "chronic", ",", "inflammatory", ",", "C0029307#ent", "<e2>", "characterized", "by", "recurrent", "flares", "."], "h": {"id": "C0162836", "name": "C0162836#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029307", "name": "C0029307#ent", "pos": [7, 8]}}
{"token": ["Such", "alterations", "may", "also", "change", "the", "therapeutic", "actions", "of", "drugs", "that", "are", "primarily", "metabolized", "by", "the", "C0534137#ent", "<e1>", "when", "administered", "to", "patients", "with", "C0036323#ent", "<e2>", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [23, 24]}}
{"token": ["C0004604#ent", "<e1>", "is", "the", "hallmark", "of", "C2827407#ent", "<e2>", "."], "h": {"id": "C0004604", "name": "C0004604#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2827407", "name": "C2827407#ent", "pos": [6, 7]}}
{"token": ["A", "previously", "healthy", "10-year-old", "patient", "with", "headache", ",", "C0004604#ent", "<e1>", ",", "and", "hearing", "loss", "diagnosed", "with", "pachymeningitis", "and", "methicillin-resistant", "Staphylococcus", "aureus", "C2827407#ent", "<e2>", "bacteremia", "."], "h": {"id": "C0004604", "name": "C0004604#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2827407", "name": "C2827407#ent", "pos": [21, 22]}}
{"token": ["Treatment", "with", "C1824810#ent", "<e1>", "induced", "the", "production", "of", "C1333960#ent", "<e2>", "including", "IL-6", "and", "GM-CSF", ",", "by", "bone", "marrow", "stromal", "cells", "young", "SAMs", "but", "stromal", "cells", "old", "SAMs", "did", "not", "respond", "to", "C1824810#ent", "<e1>", "stimulation", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333960", "name": "C1333960#ent", "pos": [8, 9]}}
{"token": ["This", "protein", "is", "a", "new", "microvillar", "C0027203#ent", "<e1>", "and", "it", "is", "proposed", "that", "it", "be", "called", "C0052527#ent", "<e2>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0052527", "name": "C0052527#ent", "pos": [16, 17]}}
{"token": ["Training", "did", "not", "enhance", "C0023816#ent", "<e1>", "regulation", "in", "a", "C0043153#ent", "<e2>", "was", "not", "recruited", "during", "running", "(", "masseter", ")", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0043153", "name": "C0043153#ent", "pos": [9, 10]}}
{"token": ["Pontin", "interacts", "directly", "with", "both", "C1705316#ent", "<e1>", "and", "C1414056#ent", "<e2>", ",", "and", "the", "amount", "of", "C1705316#ent", "<e1>", "bound", "to", "pontin", "and", "reptin", "peaks", "in", "S", "phase", "evidence", "for", "cell-cycle-dependent", "regulation", "C1705316#ent", "<e1>", "."], "h": {"id": "C1414056", "name": "C1414056#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [5, 6]}}
{"token": ["TINF2", "mutations", "were", "not", "present", "in", "unaffected", "relatives", ",", "DC", "probands", "with", "mutations", "in", "C1414056#ent", "<e1>", ",", "TERC", ",", "or", "C1705316#ent", "<e2>", "or", "298", "control", "subjects"], "h": {"id": "C1414056", "name": "C1414056#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [20, 21]}}
{"token": ["In", "C1414056#ent", "<e1>", "mutations", "in", "DCK1", ",", "TERC", ",", "and", "C1705316#ent", "<e2>", "genes", "have", "been", "identified", ",", "but", "mutations", "have", "been", "found", "in", "less", "than", "half", "of", "these", "patients", "."], "h": {"id": "C1414056", "name": "C1414056#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [10, 11]}}
{"token": ["Interestingly", ",", "EC", "C2936739#ent", "<e1>", "decreased", "myocardial", "C1367307#ent", "<e2>", "activation", "but", "increased", "myocardial", "p38", "MAPK", "activation", "in", "both", "sexes", ";", "however", ",", "this", "was", "seen", "to", "a", "greater", "degree", "in", "females", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [7, 8]}}
{"token": ["In", "line", "with", "this", ",", "the", "expression", "of", "Bcl-xl", "and", "C0281398#ent", "<e1>", "were", "decreased", "by", "C2698304#ent", "<e2>", "."], "h": {"id": "C0281398", "name": "C0281398#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2698304", "name": "C2698304#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "C0011816#ent", "<e1>", "N-demethylation", "appears", "to", "be", "catalyzed", "primarily", "by", "C1142644#ent", "<e2>", "and", "to", "a", "lesser", "extent", "by", "CYP3A5", "in", "vitro", "humans.(ABSTRACT", "TRUNCATED", "AT", "400", "WORDS", ")"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [3, 4]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "clearly", "demonstrate", "that", "C0618111#ent", "<e1>", "acts", "as", "an", "estrogen", "agonist", "C1414633#ent", "<e2>", "29.1", "cells", ",", "acting", "through", "the", "estrogen", "receptor", ",", "possibly", ",", "via", "multiple", "cooperative", "binding", "component(s", ")", "."], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414633", "name": "C1414633#ent", "pos": [12, 13]}}
{"token": ["The", "neurological", "examination", "euphoric", "mental", "state", "C0015732#ent", "<e1>", "severe", "dementia", ",", "C0030486#ent", "<e2>", ",", "dysmetria", ",", "choreic", "movements", "in", "both", "arms", "and", "urinary", "incontinence"], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030486", "name": "C0030486#ent", "pos": [11, 12]}}
{"token": ["The", "enzymes", "studied", "were", ":", "the", "protein", "tyrosine", "kinase", "PTK", ")", ",", "C0134982#ent", "<e1>", ";", "phospholipase", "C", "gamma1", "PLCgamma1", ")", ";", "and", "the", "C0026249#ent", "<e2>", "activated", "protein", "kinase", "(", "MAPK", ")", ",", "p44/42", "."], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [23, 24]}}
{"token": ["The", "average", "time", "from", "administration", "of", "the", "medication", "to", "onset", "to", "relief", "was", "74.7", "seconds", "for", "C0017887#ent", "<e1>", "and", "107.6", "seconds", "for", "chewable", "C0022252#ent", "<e2>", "dinitrate", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0022252", "name": "C0022252#ent", "pos": [23, 24]}}
{"token": ["The", "hemodynamic", "effects", "of", "intravenously", "administered", "C0017887#ent", "<e1>", "(", "TNT", ")", "and", "C0022252#ent", "<e2>", "ISDN", ")", "in", "stechiometric", "equivalent", "doses", "were", "studied", "in", "30", "patients", "with", "acute", "myocardial", "infarction"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022252", "name": "C0022252#ent", "pos": [12, 13]}}
{"token": ["The", "C3273436#ent", "<e1>", "A", "blocker", "had", "no", "effect", "on", "C1539322#ent", "<e2>", "proliferation", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [9, 10]}}
{"token": ["We", "found", "that", "the", "increase", "in", "intracellular", "[", "Ca(2+)", "by", "NA", "or", "C3273436#ent", "<e1>", "decreased", "in", "proliferating", "C1539322#ent", "<e2>", "in", "comparison", "to", "growth-arrested", "C1539322#ent", "<e2>", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [17, 18]}}
{"token": ["We", "therefore", "tested", "the", "hypothesis", "that", "C3273436#ent", "<e1>", "induces", "CD40", "in", "human", "vascular", "smooth", "muscle", "cells", "C1539322#ent", "<e2>", ")", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [16, 17]}}
{"token": ["Coincubation", "of", "C1539322#ent", "<e1>", "from", "the", "midregion", "with", "C3273436#ent", "<e2>", "plus", "TGF-beta", "resulted", "in", "an", "increase", "in", "intracellular", "big", "C3273436#ent", "<e2>", "and", "a", "decrease", "in", "C1539322#ent", "<e1>", "from", "the", "main", "artery", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [2, 3]}}
{"token": ["A", "disintegrin", "and", "C1334706#ent", "<e1>", "with", "thrombospondin", "motifs", "ADAMTS-1", ")", "belongs", "to", "the", "large", "C2984597#ent", "<e2>", "family", "of", "proteins", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2984597", "name": "C2984597#ent", "pos": [14, 15]}}
{"token": ["Tissue", "inhibitors", "metalloproteinases", "(", "TIMPs", ")", "are", "the", "endogenous", "inhibitors", "of", "the", "matrix", "metalloproteinases", "the", "ADAMs", "(", "a", "disintegrin", "and", "C1334706#ent", "<e1>", ")", "and", "the", "ADAM-TS", "(", "C2984597#ent", "<e2>", "with", "thrombospondin", "repeats", "proteinases", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2984597", "name": "C2984597#ent", "pos": [27, 28]}}
{"token": ["Thirty", "women", "with", "C0232940#ent", "<e1>", "hyperprolactinemia", "were", "studied", ";", "C0269995#ent", "<e2>", "was", "present", "in", "25", "of", "them", ",", "and", "18", "were", "infertile", "."], "h": {"id": "C0232940", "name": "C0232940#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0269995", "name": "C0269995#ent", "pos": [9, 10]}}
{"token": ["Intracellular", "transport", "of", "C1413236#ent", "<e1>", "is", "carried", "out", "by", "membrane", "vesicles", "from", "the", "known", "C0907533#ent", "<e2>", "secretory", "vesicles"], "h": {"id": "C1413236", "name": "C1413236#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}}
{"token": ["The", "dermatopathies", "included", "examples", "of", "pyoderma", "(", "folliculitis/furunculosis", ")", ",", "demodecosis", ",", "C0024710#ent", "<e1>", "dermatophytosis", ",", "endocrine", "dermatopathy", "and", "C0004364#ent", "<e2>", "AISD", ")", "."], "h": {"id": "C0024710", "name": "C0024710#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [19, 20]}}
{"token": ["The", "amyloid", "beta", "peptide", "A", "beta", ")", "of", "C0002395#ent", "<e1>", "derived", "from", "the", "proteolytic", "processing", "the", "amyloid", "precursor", "proteins", "C1705770#ent", "<e2>", ")", ",", "which", "are", "considered", "type", "I", "transmembrane", "proteins"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [8, 9]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705770", "name": "C1705770#ent", "pos": [19, 20]}}
{"token": ["Amyloid", "beta", "protein", "beta", "A4", ",", "the", "major", "component", "of", "the", "core", "of", "amyloid", "plaques", "in", "C0002395#ent", "<e1>", "is", "derived", "from", "the", "transmembrane", "amyloid", "precursor", "proteins", "(", "C1705770#ent", "<e2>", ")", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [16, 17]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705770", "name": "C1705770#ent", "pos": [27, 28]}}
{"token": ["We", "recently", "identified", "C1566685#ent", "<e1>", ",", "which", "encodes", "the", "C1335055#ent", "<e2>", "SHP-2", ",", "as", "a", "major", "NS", "disease", "."], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335055", "name": "C1335055#ent", "pos": [9, 10]}}
{"token": ["Pelvic", "inflammatory", "disease", "PID", ")", "refers", "to", "infection", "of", "the", "uterus", "(", "endometritis", ")", ",", "fallopian", "tubes", "C0036130#ent", "<e1>", ")", "and", "adjacent", "pelvic", "structures", "(", "tubo-ovarain", "complex", ",", "C0281940#ent", "<e2>", "."], "h": {"id": "C0036130", "name": "C0036130#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0281940", "name": "C0281940#ent", "pos": [28, 29]}}
{"token": ["The", "clinical", "results", "evaluated", "as", "good", "in", "3", "cases", "and", "poor", "in", "2", "cases", "including", "a", "case", "with", "C0036130#ent", "<e1>", "infected", "by", "Pseudomonas", "aeruginosa", "the", "other", "with", "C0281940#ent", "<e2>", "by", "Methicillin-resistant", "Staphylococcus", "aureus"], "h": {"id": "C0036130", "name": "C0036130#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0281940", "name": "C0281940#ent", "pos": [27, 28]}}
{"token": ["In", "adult", "DLBCL", ",", "the", "germinal", "center", "C1367452#ent", "<e1>", ")", "phenotype", "is", "associated", "with", "better", "prognosis", "than", "the", "C1332420#ent", "<e2>", "ABC", ")", "phenotype", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332420", "name": "C1332420#ent", "pos": [18, 19]}}
{"token": ["Patients", "with", "mitral", "stenosis", "some", "degree", "of", "C0235527#ent", "<e1>", "benefit", "from", "inotropic", "or", "C0042402#ent", "<e2>", "the", "early", "postoperative", "period", "."], "h": {"id": "C0235527", "name": "C0235527#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [13, 14]}}
{"token": ["As", "a", "diagnostic", "tool", "iNO", "can", "be", "used", "to", "identify", "heart", "transplant", "recipients", "at", "high", "risk", "C0235527#ent", "<e1>", "patients", "with", "primary", "pulmonary", "hypertension", "may", "benefit", "from", "C0042402#ent", "<e2>"], "h": {"id": "C0235527", "name": "C0235527#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [26, 27]}}
{"token": ["We", "conclude", "that", "the", "equilibrium", "radionuclide", "ventriculography", "be", "a", "useful", "and", "accurate", "method", "in", "diagnosing", "early", "cor", "pulmonale", "cor", "pulmonale", "C0235527#ent", "<e1>", "and", "nifedipine", "may", "not", "be", "a", "good", "C0042402#ent", "<e2>", "for", "pulmonary", "hypertension"], "h": {"id": "C0235527", "name": "C0235527#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [29, 30]}}
{"token": ["In", "this", "heterotrimeric", "complex", "the", "403", "C0007075#ent", "<e1>", "a", "central", "position", "with", "C0008746#ent", "<e2>", "proproteinase", "E", "to", "different", "surface", "sites", "it", "."], "h": {"id": "C0007075", "name": "C0007075#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008746", "name": "C0008746#ent", "pos": [12, 13]}}
{"token": ["On", "human", "umbilical", "vein", "endothelial", "cells", "C1335093#ent", "<e1>", "induced", "an", "increase", "in", "PAI-1", "and", "a", "decrease", "in", "C0078956#ent", "<e2>", "secretion", ",", "which", "could", "explain", "the", "thrombogenicity", "of", "C1335093#ent", "<e1>", "large", "vessels", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1335093", "name": "C1335093#ent", "pos": [6, 7]}}
{"token": ["The", "so", "called", "\"", "minutes", "\"", "therapy", "is", "a", "fundamental", "new", "method", "of", "C0033860#ent", "<e1>", "treatment", "with", "dithranol", "(", "C0003166#ent", "<e2>", ")", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0003166", "name": "C0003166#ent", "pos": [19, 20]}}
{"token": ["In", "a", "paired-comparison", "study", "in", "15", "hospitalized", "patients", "suffering", "from", "C0033860#ent", "<e1>", ",", "Dithrocream", "was", "compared", "with", "C0003166#ent", "<e2>", "in", "Lassar's", "paste"], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0003166", "name": "C0003166#ent", "pos": [17, 18]}}
{"token": ["For", "this", ",", "we", "chose", "the", "prototypical", "lipocalin", ",", "the", "C2757028#ent", "<e1>", "RBP", ")", "and", "its", "close", "C1334043#ent", "<e2>", "epididymal", "retinoic", "acid-binding", "protein", "ERABP", ")", "."], "h": {"id": "C2757028", "name": "C2757028#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}}
{"token": ["C0026708#ent", "<e1>", "caused", "by", "a", "deficiency", "in", "the", "C0064833#ent", "<e2>", "alpha-L-iduronidase", "."], "h": {"id": "C0026708", "name": "C0026708#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [8, 9]}}
{"token": ["Mucopolysaccharidosis", "type", "I", "MPS", "I", "McKusick", "25280", ";", "Hurler", "syndrome", "Hurler-Scheie", "syndrome", "C0026708#ent", "<e1>", "is", "caused", "by", "a", "deficiency", "in", "the", "C0064833#ent", "<e2>", "alpha-L-iduronidase", "(", "EC", "3.2.1.76", ")", "."], "h": {"id": "C0026708", "name": "C0026708#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [21, 22]}}
{"token": ["We", "present", "a", "molecular", "dynamics", "study", "C1537985#ent", "<e1>", "Paracoccus", "denitrificans", "the", "fully", "oxidized", "state", "embedded", "in", "a", "fully", "C0720930#ent", "<e2>", "dimyristoylphosphatidylcholine", "lipid", "bilayer", "membrane", "."], "h": {"id": "C1537985", "name": "C1537985#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720930", "name": "C0720930#ent", "pos": [18, 19]}}
{"token": ["C0035064#ent", "<e1>", "which", "are", "likely", "to", "be", "beneficial", "include", "amitriptyline", ",", "C0016295#ent", "<e2>", "(", "not", "available", "in", "the", "US", ")", "and", "cyproheptadine", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016295", "name": "C0016295#ent", "pos": [11, 12]}}
{"token": ["Type", "III", "3-methylglutaconic", "aciduria", "C1417132#ent", "<e1>", ")", "(", "MIM", "258501", ")", "consists", "of", "early", "C0029124#ent", "<e2>", "later", "development", "of", "spasticity", ",", "extrapyramidal", "dysfunction", "occasionally", "cognitive", "deficits", "and", "urinary", "excretion", "3-methylglutaconic", "acid", "3-methylglutaric", "acid"], "h": {"id": "C1417132", "name": "C1417132#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [14, 15]}}
{"token": ["Five", "patients", "with", "a", "clinical", "diagnosis", "buried", "or", "exposed", "C1260959#ent", "<e1>", "of", "the", "optic", "nerve", "head", "examined", "by", "computerized", "tomography", "C3813556#ent", "<e2>", ")", "."], "h": {"id": "C1260959", "name": "C1260959#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [20, 21]}}
{"token": ["Chloroaluminum", "sulfonated", "phthalocyanine", "CASPc", ")", ",", "a", "novel", "C0162830#ent", "<e1>", "was", "evaluated", "for", "treatment", "of", "experimental", "intraocular", "melanoma", "33", "rabbit", "C0235267#ent", "<e2>", "."], "h": {"id": "C0162830", "name": "C0162830#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [20, 21]}}
{"token": ["All", "surviving", "sheep", "had", "C0162830#ent", "<e1>", "in", "the", "face", ",", "ears", ",", "C0235267#ent", "<e2>", "and", "lips", "."], "h": {"id": "C0162830", "name": "C0162830#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "the", "present", "study", "showed", "no", "difference", "the", "clinical", "and", "C0003308#ent", "<e1>", "a", "single-dose", "application", "of", "C0025942#ent", "<e2>", "with", "miconazole", "gel"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [12, 13]}, "relation": "therapeutic_class_of", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [18, 19]}}
{"token": ["In", "order", "to", "develop", "new", "approaches", "to", "treatment", "of", "infections", "due", "to", "Pseudallescheria", "boydii", "the", "in", "vitro", "C0003308#ent", "<e1>", "amphotericin", "B", "and", "in", "combination", "with", "C0025942#ent", "<e2>", ",", "itraconazole", ",", "and", "fluconazole", "was", "studied", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [17, 18]}, "relation": "therapeutic_class_of", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [25, 26]}}
{"token": ["C1439342#ent", "<e1>", "GMF", ")", "is", "a", "C1423014#ent", "<e2>", "to", "the", "nervous", "system"], "h": {"id": "C1439342", "name": "C1439342#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423014", "name": "C1423014#ent", "pos": [6, 7]}}
{"token": ["Glia", "maturation", "factor-beta", "C1439342#ent", "<e1>", ")", "is", "a", "C1423014#ent", "<e2>", "was", "initially", "identified", "as", "a", "growth", "and", "differentiation", "factor", "on", "neurons", "as", "well", "as", "glia", "in", "the", "vertebrate", "brain"], "h": {"id": "C1439342", "name": "C1439342#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423014", "name": "C1423014#ent", "pos": [8, 9]}}
{"token": ["C0025405#ent", "<e1>", "was", "as", "good", "as", "DHT", "in", "ameliorating", "C1415041#ent", "<e2>", "(", "P", ">", "0.05", ")", "and", "better", "than", "DHT", "in", "scavenging", "ROM", "P", "<", "0.05", ")", "."], "h": {"id": "C0025405", "name": "C0025405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415041", "name": "C1415041#ent", "pos": [9, 10]}}
{"token": ["In", "this", "article", ",", "Tanya", "Roberts", ",", "Darwin", "Murrell", "and", "Suzanne", "Marks", "discuss", "the", "cost", "of", "toxoplasmosis", ",", "C0039254#ent", "<e1>", ",", "cysticercosis", ",", "trichinellosis", "and", "other", "foodborne", "C0747256#ent", "<e2>"], "h": {"id": "C0039254", "name": "C0039254#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [27, 28]}}
{"token": ["Coexpression", "of", "C0534628#ent", "<e1>", "along", "with", "C2349086#ent", "<e2>", "reversed", "the", "tumorigenic", "phenotype", "of", "VR", "cells"], "h": {"id": "C0534628", "name": "C0534628#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [6, 7]}}
{"token": ["Matrix", "metalloproteinase-9", "MMP-9", ")", ",", "C0534628#ent", "<e1>", "(", "ES", ")", "and", "vascular", "endothelial", "growth", "factor", "C2349086#ent", "<e2>", ")", "are", "important", "angiogenic", "regulators", "many", "neoplasms", "."], "h": {"id": "C0534628", "name": "C0534628#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [15, 16]}}
{"token": ["C0534628#ent", "<e1>", "and", "doxorubicin", "synergized", "to", "down-regulate", "C2349086#ent", "<e2>", "expression", "."], "h": {"id": "C0534628", "name": "C0534628#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [7, 8]}}
{"token": ["Six", "migraine", "patients", "experienced", "significant", "topiramate-related", "cognitive", "and", "language", "dysfunction", "improved", "with", "C0771848#ent", "<e1>", "treatment", "and", "allowed", "uninterrupted", "C0076829#ent", "<e2>", "use", "."], "h": {"id": "C0771848", "name": "C0771848#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "C1956003#ent", "<e1>", "regulation", "of", "C0022614#ent", "<e2>", "receptor-dependent", "synaptic", "plasticity", "involves", "heterogeneous", "molecular", "mechanisms", "in", "both", "different", "dendritic", "subregions", "and", "different", "neuronal", "subtypes"], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [6, 7]}}
{"token": ["Wiskott-Aldrich", "syndrome", "WAS", ")", "is", "an", "C1279481#ent", "<e1>", "by", "thrombocytopenia", "with", "small", "platelets", ",", "eczema", ",", "recurrent", "infections", "C0004364#ent", "<e2>", "IgA", "nephropathy", "and", "an", "increased", "incidence", "of", "hematopoietic", "malignancies"], "h": {"id": "C1279481", "name": "C1279481#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [18, 19]}}
{"token": ["Wiskott-Aldrich", "syndrome", "WAS", ")", "is", "a", "rare", "C1279481#ent", "<e1>", "microthrombocytopenia", ",", "eczema", ",", "recurrent", "infections", "C0004364#ent", "<e2>", "and", "malignancies", "that", "are", "life-threatening", "in", "the", "majority", "of", "patients", "."], "h": {"id": "C1279481", "name": "C1279481#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [15, 16]}}
{"token": ["When", "compared", "to", "placebo", "or", "control", "patients", ",", "both", "doses", "of", "C0008783#ent", "<e1>", "significantly", "(", "P", "less", "than", "0.01", ")", "decreased", "the", "C0018834#ent", "<e2>", "and", "volume", "of", "gastric", "contents", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0018834", "name": "C0018834#ent", "pos": [22, 23]}}
{"token": ["Combination", "therapy", "C0042679#ent", "<e1>", "and", "FK506", "or", "C1705389#ent", "<e2>", "produced", "synergistic", "effects", "prevention", "of", "acute", "heart", "allograft", "in", "the", "rat", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705389", "name": "C1705389#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "suggest", "that", "C1332036#ent", "<e1>", "inhibits", "JNK", "activity", "by", "affecting", "the", "downstream", "signal", "of", "C1335273#ent", "<e2>", "in", "a", "SHP-1-dependent", "manner", ",", "leading", "to", "a", "decrease", "in", "c-Jun", "expression"], "h": {"id": "C1332036", "name": "C1332036#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335273", "name": "C1335273#ent", "pos": [15, 16]}}
{"token": ["These", "effects", "of", "ethanol", "withdrawal", "were", "decreased", "by", "the", "(", "+", ")", "isomer", "of", "C0004855#ent", "<e1>", "that", "is", "a", "C3536851#ent", "<e2>"], "h": {"id": "C0004855", "name": "C0004855#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3536851", "name": "C3536851#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "suggest", "that", "activation", "of", "a", "C1533641#ent", "<e1>", "alter", "the", "normal", "differentiation", "program", "epidermal", "cells", "that", "the", "ability", "to", "synthesize", "C1416746#ent", "<e2>", "and", "CK18", "could", "be", "related", "to", "tumor", "progression"], "h": {"id": "C1533641", "name": "C1533641#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416746", "name": "C1416746#ent", "pos": [21, 22]}}
{"token": ["It", "is", "possible", "that", "C1413109#ent", "<e1>", "functions", "as", "one", "of", "the", "proteoglycan-degrading", "proteolytic", "C3540772#ent", "<e2>", "of", "growth", "cartilage"], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [13, 14]}}
{"token": ["Each", "subunit", "of", "C1413109#ent", "<e1>", "(", "EC", "3.4.22.17", ")", "is", "proteolytically", "modified", "when", "the", "C3540772#ent", "<e2>", "are", "exposed", "to", "calcium", "."], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [14, 15]}}
{"token": ["In", "India", ",", "the", "standard", "treatment", "prevent", "relapses", "of", "C0024537#ent", "<e1>", "malaria", "is", "a", "5-day", "regimen", "of", "C0033126#ent", "<e2>", "."], "h": {"id": "C0024537", "name": "C0024537#ent", "pos": [9, 10]}, "relation": "may_be_prevented_by", "t": {"id": "C0033126", "name": "C0033126#ent", "pos": [17, 18]}}
{"token": ["Inhibition", "of", "neoplastic", "transformation", "the", "pro-vitamin", "A", "carotenoid", "beta-carotene", ",", "but", "not", "by", "the", "non-pro-vitamin", "A", "C0085210#ent", "<e1>", "was", "moderately", "potentiated", "by", "C2697919#ent", "<e2>", "."], "h": {"id": "C0085210", "name": "C0085210#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2697919", "name": "C2697919#ent", "pos": [22, 23]}}
{"token": ["Additionally", ",", "C1836668#ent", "<e1>", "can", "be", "associated", "with", "autoimmune", "diseases", "as", "C1527336#ent", "<e2>", "primary", "sclerosing", "cholangitis", "chronic", "inflammatory", "bowel", "diseases", "and", "retroperitoneal", "fibrosis"], "h": {"id": "C1836668", "name": "C1836668#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [11, 12]}}
{"token": ["The", "putative", "active", "site", "residues", "of", "these", "domains", "are", "followed", "by", "an", "aliphatic", "amino", "acid", ",", "whereas", "an", "C4284104#ent", "<e1>", "this", "position", "is", "typical", "of", "cellular", "and", "previously", "characterized", "C0006784#ent", "<e2>"], "h": {"id": "C4284104", "name": "C4284104#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [29, 30]}}
{"token": ["The", "interaction", "between", "C1539748#ent", "<e1>", "and", "SEPT11", "requires", "the", "C1528775#ent", "<e2>", "the", "C-terminal", "extension"], "h": {"id": "C1539748", "name": "C1539748#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1528775", "name": "C1528775#ent", "pos": [9, 10]}}
{"token": ["We", "found", "that", "C0003873#ent", "<e1>", "rapidly", "activates", "the", "protein", "kinase", "Calpha", "isozyme", "transmits", "the", "activation", "signal", "C1413702#ent", "<e2>", "via", "the", "Raf/MEK/extracellular", "signal-regulated", "kinase/p90", "ribosomal", "S6", "kinase", "(", "RSK", ")", "pathway", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413702", "name": "C1413702#ent", "pos": [16, 17]}}
{"token": ["Until", "the", "early", "1990s", "six", "major", "compounds", "(", "carbamazepine", ",", "ethosuximide", ",", "phenobarbital", ",", "phenytoin", ",", "C0033148#ent", "<e1>", ",", "and", "valproic", "acid", "were", "available", "for", "the", "treatment", "of", "C0014547#ent", "<e2>", "."], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [28, 29]}}
{"token": ["C0033148#ent", "<e1>", "given", "to", "a", "patient", "for", "C0014547#ent", "<e2>", "produced", "an", "unexpected", "reduction", "in", "benign", "familial", "tremor"], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [7, 8]}}
{"token": ["Pertussis", "(", "C0043168#ent", "<e1>", "is", "a", "contagious", "respiratory", "tract", "C0004623#ent", "<e2>", "to", "Bordetella", "pertussis", "makes", "global", "comeback", "despite", "routine", "vaccination", "."], "h": {"id": "C0043168", "name": "C0043168#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [9, 10]}}
{"token": ["The", "C0151747#ent", "<e1>", "is", "considered", "most", "often", "is", "renal", "tubular", "acidosis", "C0001126#ent", "<e2>", ")", "."], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001126", "name": "C0001126#ent", "pos": [11, 12]}}
{"token": ["Plasma", "and", "serum", "biochemical", "evaluations", "indicated", "a", "proximal", "C0151747#ent", "<e1>", "manifested", "as", "C0001126#ent", "<e2>", "phosphate", "loss"], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001126", "name": "C0001126#ent", "pos": [12, 13]}}
{"token": ["Following", "activation", "subsequent", "to", "cerebral", "ischemia", "reperfusion", "injury", "C2986464#ent", "<e1>", "acts", "on", "genes", "for", "cytokines", ",", "adhesion", "molecules", "C0132555#ent", "<e2>", "cyclooxygenase-2", ",", "metalloproteinase-9", ",", "and", "perhaps", "apoptotic", "genes"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [18, 19]}}
{"token": ["The", "inhibitors", "also", "reversibly", "prevented", "the", "induction", "of", "the", "C2986464#ent", "<e1>", "which", "is", "required", "for", "the", "expression", "of", "C0132555#ent", "<e2>", "NOS", ")", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [18, 19]}}
{"token": ["These", "C1415363#ent", "<e1>", "knockout", "mice", "indistinguishable", "initially", "from", "C2987364#ent", "<e2>", "littermates", ",", "except", "that", "males", "and", "females", "had", "female", "external", "genitalia", "."], "h": {"id": "C1415363", "name": "C1415363#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}}
{"token": ["Because", "the", "expression", "of", "small", "heterodimer", "partner", "C1334896#ent", "<e1>", ")", "mRNA", "was", "induced", "by", "chenodeoxycholic", "acid", "HepG2", "cells", "we", "analyzed", "the", "effects", "of", "C1334896#ent", "<e1>", "on", "the", "human", "C0051844#ent", "<e1>", "promoter", "."], "h": {"id": "C1334896", "name": "C1334896#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [28, 29]}}
{"token": ["C1334896#ent", "<e1>", "repressed", "human", "C0051844#ent", "<e2>", "promoter", "activity", "when", "the", "HNF-4", "expression", "vector", "was", "cotransfected", "in", "HeLa", "cells"], "h": {"id": "C1334896", "name": "C1334896#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [4, 5]}}
{"token": ["The", "results", "suggest", "that", "C1421333#ent", "<e1>", "is", "a", "key", "C1259497#ent", "<e2>", "isoform", "for", "the", "metabolism", "of", "flavonoids", ",", "and", "that", "absorption", "of", "intact", "flavonoid", "glycosides", "possible", "."], "h": {"id": "C1421333", "name": "C1421333#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1259497", "name": "C1259497#ent", "pos": [9, 10]}}
{"token": ["More", "clinical", "data", "required", "on", "the", "role", "of", "C0060926#ent", "<e1>", "in", "children", "and", "additional", "monotherapy", "experience", "is", "required", "before", "the", "role", "of", "C0060926#ent", "<e1>", "in", "the", "overall", "treatment", "C0014544#ent", "<e1>", "can", "be", "better", "defined", "."], "h": {"id": "C0060926", "name": "C0060926#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [28, 29]}}
{"token": ["Immunohistochemical", "labeling", "abundant", "C1412495#ent", "<e1>", "in", "secretory", "parts", "rat", "and", "C0038986#ent", "<e2>", "where", "immunoelectron", "microscopy", "abundant", "C1412495#ent", "<e1>", "labeling", "in", "the", "apical", "plasma", "membrane"], "h": {"id": "C1412495", "name": "C1412495#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038986", "name": "C0038986#ent", "pos": [10, 11]}}
{"token": ["Treatment", "of", "cells", "with", "C0082782#ent", "<e1>", ",", "a", "selective", "PKA", "inhibitor", ",", "totally", "blocked", "C3539616#ent", "<e2>", "release", "caused", "by", "either", "GRF", "or", "GHRP-2", "and", "partially", "reduced", "PMA-induced", "C3539616#ent", "<e2>", "release", "."], "h": {"id": "C0082782", "name": "C0082782#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [14, 15]}}
{"token": ["When", "a", "protein", "kinase", "A", "PKA", ")", "inhibitor", "(", "C0082782#ent", "<e1>", ")", "was", "applied", ",", "GHRH", "stimulated", "C3539616#ent", "<e2>", "release", "was", "blocked", ",", "but", "cAMP", "accumulation", "was", "not", "affected", "."], "h": {"id": "C0082782", "name": "C0082782#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [17, 18]}}
{"token": ["Phenylalanine", "and", "homogentisate", "increase", "the", "concentration", "of", "succinylacetoacetate", "and", "C0075455#ent", "<e1>", "both", "in", "serum", "and", "urine", "in", "patients", "with", "C0268490#ent", "<e2>", "therefore", "increase", "the", "excretion", "of", "5-aminolevulinate", "."], "h": {"id": "C0075455", "name": "C0075455#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268490", "name": "C0268490#ent", "pos": [19, 20]}}
{"token": ["Succinylacetone", "(", "C0075455#ent", "<e1>", ",", "an", "abnormal", "metabolic", "product", "secondary", "to", "C0268490#ent", "<e2>", "found", "in", "serum", "and", "urine", "."], "h": {"id": "C0075455", "name": "C0075455#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268490", "name": "C0268490#ent", "pos": [11, 12]}}
{"token": ["Elevation", "of", "C0075455#ent", "<e1>", "was", "found", "in", "32", "of", "the", "35", "patients", "with", "C0268490#ent", "<e2>", "the", "enzyme", "assay", "carried", "out", "."], "h": {"id": "C0075455", "name": "C0075455#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268490", "name": "C0268490#ent", "pos": [13, 14]}}
{"token": ["When", "RLM3", "and", "RLM5", "were", "digested", "with", "C0030940#ent", "<e1>", "peptide", "maps", "showed", "that", "these", "two", "C0010762#ent", "<e2>", "different", "primary", "structures"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [15, 16]}}
{"token": ["In", "C0919426#ent", "<e1>", "expressing", "cells", ",", "the", "alpha", "and", "C1701621#ent", "<e2>", "RNA", "(", "mRNA", ")", "are", "increased", "by", "4-", "and", "2-fold", ",", "respectively", ",", "and", "catalase", "protein", "mRNA", "is", "increased", "by", "2-fold", "."], "h": {"id": "C0919426", "name": "C0919426#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1701621", "name": "C1701621#ent", "pos": [9, 10]}}
{"token": ["In", "clinical", "isolates", "of", "Enterobacter", "cloacae", "resistance", "to", "the", "newer", "beta-lactam", "antibiotics", "results", "from", "C0221406#ent", "<e1>", "of", "a", "C0728805#ent", "<e2>", "encoded", "by", "the", "beta-lactam-inducible", "ampC", "gene", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0728805", "name": "C0728805#ent", "pos": [18, 19]}}
{"token": ["Among", "the", "cephalosporins", ",", "cefepime", "was", "the", "least", "affected", "by", "the", "C0221406#ent", "<e1>", "of", "constitutive", "C0728805#ent", "<e2>", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0728805", "name": "C0728805#ent", "pos": [15, 16]}}
{"token": ["When", "AmpC", "production", "increases", "through", "mutational", "events", "C0221406#ent", "<e1>", "of", "this", "C0728805#ent", "<e2>", "provides", "high-level", "resistance", "to", "all", "beta-lactams", "except", "the", "carbapenems", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0728805", "name": "C0728805#ent", "pos": [11, 12]}}
{"token": ["Among", "the", "cephalosporines", "tested", ",", "cefepime", "was", "less", "affected", "by", "the", "C0221406#ent", "<e1>", "of", "constitutive", "C0728805#ent", "<e2>", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0728805", "name": "C0728805#ent", "pos": [15, 16]}}
{"token": ["Several", "C0031727#ent", "<e1>", "can", "phosphorylate", "Fra-1", "and", "Fra-2", "in", "vitro", "including", "C1514550#ent", "<e2>", "PKA", ")", ",", "protein", "kinase", "C", "PKC", ")", ",", "cyclin-dependent", "kinase", "1-cdc2", "cdc2", ")", ",", "and", "mitogen", "activated", "protein", "MAP", ")", "kinase", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "synthesis", "of", "GFAP", "is", "also", "inhibited", "by", "cellular", "uptake", "non-selective", "nucleotide", "receptor", "antagonists", "that", "inhibit", "PI", "3-K", ",", "a", "C0031727#ent", "<e1>", "required", "for", "the", "C1514550#ent", "<e2>", "induction", "of", "differentiation", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [27, 28]}}
{"token": ["Pretreatment", "with", "two", "different", "5-HT3", "receptor", "antagonists", "LY-278,584", "and", "ondansetron", ",", "was", "also", "able", "to", "produce", "a", "significant", "reduction", "in", "the", "C1263960#ent", "<e1>", "response", "evoked", "by", "central", "administration", "C0034441#ent", "<e2>", "."], "h": {"id": "C1263960", "name": "C1263960#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0034441", "name": "C0034441#ent", "pos": [28, 29]}}
{"token": ["The", "correlation", "between", "obstruction", "of", "the", "upper", "respiratory", "tract", "the", "degree", "of", "C3887547#ent", "<e1>", "investigated", "in", "60", "patients", "with", "C0520679#ent", "<e2>", "diagnosed", "by", "polysomnography", ")", "and", "in", "55", "healthy", "controls"], "h": {"id": "C3887547", "name": "C3887547#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0520679", "name": "C0520679#ent", "pos": [19, 20]}}
{"token": ["In", "this", "setting", ",", "C3887547#ent", "<e1>", "which", "includes", "C0520679#ent", "<e2>", "central", "sleep", "apnea", "is", "being", "increasingly", "recognized", "as", "a", "potentially", "modifiable", "risk", "factor", "for", "coronary", "artery", "disease"], "h": {"id": "C3887547", "name": "C3887547#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0520679", "name": "C0520679#ent", "pos": [8, 9]}}
{"token": ["C1706383#ent", "<e1>", "and", "the", "Fos-related", "antigens", "C1538772#ent", "<e2>", ")", "are", "induced", "by", "various", "stimuli", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538772", "name": "C1538772#ent", "pos": [6, 7]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "analyze", "the", "temporal", "and", "spatial", "patterns", "expression", "of", "the", "inducible", "transcription", "protein", "C1706383#ent", "<e1>", "and", "the", "Fos-related", "antigens", "C1538772#ent", "<e2>", ")", "in", "developing", "rat", "teeth", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1538772", "name": "C1538772#ent", "pos": [25, 26]}}
{"token": ["These", "findings", "suggest", "that", "DDE", "may", "inhibit", "the", "expression", "of", "C1442762#ent", "<e1>", "and", "up-modulate", "expression", "of", "C1366439#ent", "<e2>", "in", "cultured", "rat", "Sertoli", "cells"], "h": {"id": "C1442762", "name": "C1442762#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [16, 17]}}
{"token": ["There", "existed", "an", "obvious", "dose-effect", "relationship", "between", "the", "concentration", "of", "DDE", "and", "the", "expression", "levels", "of", "C1442762#ent", "<e1>", "mRNA", "and", "C1366439#ent", "<e2>", "mRNA", "."], "h": {"id": "C1442762", "name": "C1442762#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [20, 21]}}
{"token": ["Three", "of", "the", "cases", "developed", "subarachnoid", "haemorrhage", "C1825840#ent", "<e1>", ")", ",", "while", "the", "other", "one", "suffered", "from", "C0043019#ent", "<e2>"], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0043019", "name": "C0043019#ent", "pos": [17, 18]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "investigate", "the", "mechanisms", "underlying", "the", "decrease", "in", "hepatic", "clearance", "of", "some", "drugs", "metabolized", "by", "C0010762#ent", "<e1>", "enzymes", "in", "C1561643#ent", "<e2>", "CRI", ")", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [25, 26]}}
{"token": ["We", "concluded", "that", "the", "demethylation", "activity", "of", "the", "C0010762#ent", "<e1>", "not", "distinctly", "influenced", "by", "C1561643#ent", "<e2>"], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [14, 15]}}
{"token": ["Even", "though", "the", "homology", "between", "C1704697#ent", "<e1>", "and", "crystallographically", "solved", ",", "functionally", "related", "C0086376#ent", "<e2>", "is", "not", "very", "high", ",", "a", "three-dimensional", "model", "C1704697#ent", "<e1>", "was", "derived", "using", "Modeller", "Software"], "h": {"id": "C1704697", "name": "C1704697#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["C1704697#ent", "<e1>", "directly", "induce", "the", "expression", "of", "C0086376#ent", "<e2>", "displaying", "anti-inflammatory", "activities"], "h": {"id": "C1704697", "name": "C1704697#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}}
{"token": ["This", "paper", "advocates", "the", "principle", "of", "ulnar", "nerve", "decompression", "medial", "epicondylectomy", "the", "humerus", "in", "C0023343#ent", "<e1>", "patients", "presenting", "with", "ulnar", "nerve", "neuritis", "early", "C0030552#ent", "<e2>", "ulnar", "nerve", "muscles", "."], "h": {"id": "C0023343", "name": "C0023343#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [23, 24]}}
{"token": ["Two", "heat", "sensitive", "channels", "TRPV1", "and", "C1425291#ent", "<e1>", ",", "and", "a", "cold-sensitive", "channel", ",", "C1412407#ent", "<e2>", ",", "were", "detected", "by", "RT-PCR", "."], "h": {"id": "C1425291", "name": "C1425291#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412407", "name": "C1412407#ent", "pos": [14, 15]}}
{"token": ["By", "using", "an", "C1334118#ent", "<e1>", "minigene", "construct", "genomic", "DNA", "mRNA", "from", "asthma", "patients", "and", "C0004096#ent", "<e2>", "individuals", ",", "we", "analyzed", "the", "function", "of", "four", "highly-linked", "SNPs", ",", "flanking", "the", "alternatively-spliced", "exon", "in", "the", "IL4R", "gene"], "h": {"id": "C1334118", "name": "C1334118#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "the", "C1334118#ent", "<e1>", "not", "seem", "to", "play", "an", "important", "role", "in", "genetic", "predisposition", "C0004096#ent", "<e2>", "the", "population", "tested", "."], "h": {"id": "C1334118", "name": "C1334118#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "replicate", "this", "association", "and", "confirm", "the", "possible", "role", "of", "the", "Ile50Val", "polymorphism", "of", "C1334118#ent", "<e1>", "in", "the", "etiology", "of", "C0004096#ent", "<e2>", "a", "Japanese", "population", "."], "h": {"id": "C1334118", "name": "C1334118#ent", "pos": [20, 21]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [26, 27]}}
{"token": ["We", "have", "shown", "that", "the", "types", "of", "mutations", "induced", "by", "these", "C0596240#ent", "<e1>", "different", "from", "those", "induced", "by", "the", "C2987364#ent", "<e2>", "enzyme", "."], "h": {"id": "C0596240", "name": "C0596240#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [19, 20]}}
{"token": ["Polydipsic", "C0857122#ent", "<e1>", "schizophrenic", "patients", "(", "C0265220#ent", "<e2>", ")", "exhibit", "enhanced", "plasma", "arginine", "vasopressin", "pAVP", ")", "and", "hypothalamic", "pituitary", "adrenal", "HPA", ")", "axis", "responses", "stress", "that", "appear", "attributable", "to", "anterior", "hippocampal", "dysfunction", "."], "h": {"id": "C0857122", "name": "C0857122#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0265220", "name": "C0265220#ent", "pos": [6, 7]}}
{"token": ["Dietary", "PCBs", "potentiated", "a", "C0376286#ent", "<e1>", "the", "chick", ",", "increased", "C1299926#ent", "<e2>", "and", "decreased", "plasma", "glutathione", "peroxidase", "levels", "."], "h": {"id": "C0376286", "name": "C0376286#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1299926", "name": "C1299926#ent", "pos": [10, 11]}}
{"token": ["The", "actuarial", "survival", "all", "patients", "was", "53", "%", "at", "6", "years", ",", "with", "79", "%", "survival", "for", "C1883018#ent", "<e1>", "NSAA", ")", "and", "36", "%", "for", "severe", "C0002874#ent", "<e2>", "SAA", ")", "."], "h": {"id": "C1883018", "name": "C1883018#ent", "pos": [17, 18]}, "relation": "has_nichd_parent", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [26, 27]}}
{"token": ["We", "report", "two", "cases", "of", "C0026946#ent", "<e1>", "prosthetic", "joints", "which", "were", "successfully", "treated", "by", "incorporation", "of", "C0016277#ent", "<e2>", "into", "polymethylmethacrylate", "beads", "at", "the", "time", "of", "debridement", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [16, 17]}}
{"token": ["The", "C0026946#ent", "<e1>", "successfully", "controlled", "using", "C0016277#ent", "<e2>", ",", "and", "the", "patient", "has", "been", "disease-free", "for", "more", "than", "11", "months", "after", "antileukemic", "chemotherapy", "without", "any", "recurrence", "of", "Candida", "infections"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [1, 2]}, "relation": "may_be_prevented_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [6, 7]}}
{"token": ["Previous", "studies", "determined", "that", "the", "transcription", "factors", "and", "C1705599#ent", "<e1>", "are", "important", "for", "C1415067#ent", "<e2>", "expression", "."], "h": {"id": "C1705599", "name": "C1705599#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415067", "name": "C1415067#ent", "pos": [13, 14]}}
{"token": ["The", "dry", "matter", "digestibility", "of", "94", "species", "of", "leaf", "was", "assayed", "by", "a", "simple", "method", "involving", "sequential", "treatment", "C0030909#ent", "<e1>", "and", "fungal", "C0007641#ent", "<e2>", "enzymes", "."], "h": {"id": "C0030909", "name": "C0030909#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0007641", "name": "C0007641#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "the", "prevalence", ",", "duration", ",", "and", "etiology", "of", "C0004610#ent", "<e1>", "following", "dental", "extractions", "after", "a", "single", "administration", "of", "C0352155#ent", "<e2>"], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0352155", "name": "C0352155#ent", "pos": [20, 21]}}
{"token": ["The", "effects", "of", "exogenously", "added", "C1413043#ent", "<e1>", "+", "on", "the", "enzymatic", "activity", "structural", "stability", "C0051114#ent", "<e2>", "studied", "for", "various", "C1413043#ent", "<e1>", "+", "concentrations", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0051114", "name": "C0051114#ent", "pos": [14, 15]}}
{"token": ["The", "results", "revealed", "that", "rearranged", "V3", "-", "7", "C1417679#ent", "<e1>", "in", "IgM+IgD+B", "cells", "from", "patients", "with", "C0014060#ent", "<e2>", "contained", "somatically", "mutated", "sequences", "at", "significantly", "increased", "frequencies", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [16, 17]}}
{"token": ["Hybridization", "analysis", "BHV1.1", "cloned", "probes", "of", "the", "immediate-early", "protein", "gene", "thymidine", "kinase", "gene", "DNA", "binding/DNA", "polymerase", "gene", "and", "glycoprotein", "III", "gene", "information", "for", "mapping", "of", "these", "C1417679#ent", "<e1>", "to", "the", "BHV5", "C0014060#ent", "<e2>", "isolate", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [31, 32]}}
{"token": ["C0023645#ent", "<e1>", "results", "in", "scaling", ",", "atrophy", ",", "and", "C0002170#ent", "<e2>", "scarring", "and", "is", "thought", "to", "be", "autoimmune", "in", "origin", "."], "h": {"id": "C0023645", "name": "C0023645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [9, 10]}}
{"token": ["Both", "blood", "pressure", "baroreflex", "effects", "were", "antagonized", "by", "prior", "injections", "of", "specific", "serotonin3", "antagonists", "such", "as", "C0078743#ent", "<e1>", "(", "100", "pmol", ")", "and", "C0061851#ent", "<e2>", "(", "100", "pmol", ")", "."], "h": {"id": "C0078743", "name": "C0078743#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0061851", "name": "C0061851#ent", "pos": [23, 24]}}
{"token": ["This", "article", "reports", "on", "recent", "findings", "of", "improvement", "in", "C1419789#ent", "<e1>", "using", "high", "doses", "the", "histamine-2", "receptor", "antagonist", "C0034665#ent", "<e2>", "in", "long-term", "studies", "."], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [18, 19]}}
{"token": ["Histamine", "is", "suggested", "to", "be", "involved", "in", "the", "pathogenesis", "of", "C1419789#ent", "<e1>", "and", "the", "histamine-2", "receptor", "antagonist", "C0034665#ent", "<e2>", "has", "been", "shown", "to", "be", "of", "value", "to", "reduce", "severe", "psoriatic", "disease", "."], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [17, 18]}}
{"token": ["Nisoldipine", "again", ",", "was", "more", "potent", "than", "C0028066#ent", "<e1>", "in", "the", "inhibition", "of", "C0002963#ent", "<e2>", "not", "in", "the", "contraction", "of", "femoral", "artery"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [13, 14]}}
{"token": ["C0028066#ent", "<e1>", "has", "proved", "effective", "in", "preventing", "coronary", "arterial", "spasm", "patients", "with", "C0002963#ent", "<e2>"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [12, 13]}}
{"token": ["Although", "C0028066#ent", "<e1>", "is", "highly", "effective", "against", "C0002963#ent", "<e2>", "its", "use", "in", "threatened", "myocardial", "infarction", "severe", "unstable", "angina", "is", "not", "supported", "by", "recent", "studies", ",", "unless", "combined", "with", "a", "beta-blocker", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [7, 8]}}
{"token": ["The", "efficacy", "of", "nicorandil", "was", "compared", "with", "that", "of", "C0028066#ent", "<e1>", "in", "13", "patients", "with", "C0002963#ent", "<e2>", "in", "a", "randomized", ",", "placebo-controlled", ",", "crossover", "study"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [15, 16]}}
{"token": ["Comparison", "of", "the", "nucleotide", "and", "deduced", "amino", "acid", "sequences", "C1414402#ent", "<e1>", "with", "that", "of", "the", "C1512488#ent", "<e2>", "Oryza", "sativa", "L.", "RINO1", ")", "revealed", "distinct", "differences", "in", "a", "stretch", "of", "37", "amino", "acids", "between", "amino", "acids", "174", "210", "."], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [15, 16]}}
{"token": ["Only", "one", "C1414402#ent", "<e1>", "be", "detected", "in", "N.", "frontalis", "genomic", "DNA", "Southern", "analysis", "a", "C1512488#ent", "<e2>"], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [14, 15]}}
{"token": ["Thylakoid-bound", "superoxide", "dismutase", "(", "SOD", ";", "C1743497#ent", "<e1>", "was", "solubilized", "by", "C0146951#ent", "<e2>", "spinach", "and", "purified", "to", "a", "homogeneous", "state"], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [11, 12]}}
{"token": ["C1743497#ent", "<e1>", "delipidated", "by", "solvent", "extraction", "guanidine", "was", "reconstituted", "with", "C0146951#ent", "<e2>", "several", "methods", ",", "and", "the", "products", "were", "examined", "immunologically", "."], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [10, 11]}}
{"token": ["C1743497#ent", "<e1>", "delipidated", "by", "lipid", "displacement", "using", "C0146951#ent", "<e2>", "virtually", "identical", "to", "LDL-apo-B", "in", "both", "systems", ",", "as", "assayed", "by", "polyclonal", "antisera", "in", "rabbits", "against", "either", "antigen", "."], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [7, 8]}}
{"token": ["In", "conclusion", ",", "C0028066#ent", "<e1>", "retard", "and", "enalapril", "had", "a", "similar", "effect", "on", "C0017661#ent", "<e2>", "in", "hypertensive", "type", "2", "diabetic", "patients", "without", "overt", "proteinuria", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [13, 14]}}
{"token": ["The", "dephosphorylation", "of", "the", "myosin", "light", "chain", "kinase", "C0033634#ent", "<e1>", "the", "20", "kDa", "C1417546#ent", "<e2>", "myosin", "phosphatase", "investigated", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417546", "name": "C1417546#ent", "pos": [13, 14]}}
{"token": ["Among", "these", "proteins", "we", "have", "identified", "two", "C0170168#ent", "<e1>", "MAPK", ")", "isoforms", "of", "43", "kDa", "(", "C1419881#ent", "<e2>", "MAPK", ")", "and", "45", "kDa", "(", "p45", "MAPK", "molecular", "mass"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419881", "name": "C1419881#ent", "pos": [16, 17]}}
{"token": ["In", "a", "prospective", "study", "66", "patients", "fulfilling", "the", "criteria", "of", "C0151449#ent", "<e1>", "evaluated", "from", "the", "standpoint", "of", "the", "presence", "of", "soluble", "C1722829#ent", "<e2>", ",", "SS-B", "and", "RNP", "specific", "nuclear", "antigen", "antibodies"], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1722829", "name": "C1722829#ent", "pos": [21, 22]}}
{"token": ["Abnormalities", "of", "the", "C1413861#ent", "<e1>", "serve", "as", "a", "marker", "for", "C1621895#ent", "<e2>"], "h": {"id": "C1413861", "name": "C1413861#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1621895", "name": "C1621895#ent", "pos": [10, 11]}}
{"token": ["Although", "the", "etiology", "of", "C1527336#ent", "<e1>", "C0036391#ent", "<e2>", ")", "remains", "unknown", ",", "C1527336#ent", "<e1>", "be", "diagnosed", "by", "means", "of", "clinical", "features", "and", "sialographic", "and", "histopathological", "examinations", "."], "h": {"id": "C0036391", "name": "C0036391#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [4, 5]}}
{"token": ["Neutralization", "of", "C0018834#ent", "<e1>", "or", "reduction", "of", "gastric", "juice", "mean", "of", "C0074722#ent", "<e2>", "or", "cimetidine", ",", "respectively", ",", "did", "not", "modify", "the", "effect", "of", "the", "peptide", "."], "h": {"id": "C0018834", "name": "C0018834#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0074722", "name": "C0074722#ent", "pos": [11, 12]}}
{"token": ["C0009018#ent", "<e1>", "LC", ")", "is", "a", "NSAID", "derived", "from", "C3536880#ent", "<e2>", "has", "proven", "to", "be", "effective", "in", "various", "pain", "syndromes", "as", "renal", "colic", "muscular", "pain"], "h": {"id": "C0009018", "name": "C0009018#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536880", "name": "C3536880#ent", "pos": [9, 10]}}
{"token": ["C0165631#ent", "<e1>", "is", "a", "synthetic", "retinoid", "an", "established", "clinical", "efficacy", "C0001144#ent", "<e2>", "and", "good", "local", "tolerability", "."], "h": {"id": "C0165631", "name": "C0165631#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0001144", "name": "C0001144#ent", "pos": [10, 11]}}
{"token": ["CPO", "inhibited", "CYP1A2", "production", "of", "C0027375#ent", "<e1>", "metabolites", ",", "while", "activating", "their", "production", "by", "C1176140#ent", "<e2>", "."], "h": {"id": "C0027375", "name": "C0027375#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [14, 15]}}
{"token": ["We", "have", "recently", "shown", "that", "bovine", "sperm", "C0300252#ent", "<e1>", "is", "stimulated", "by", "PDC-109", ",", "a", "C1332754#ent", "<e2>", "bovine", "seminal", "vesicles"], "h": {"id": "C0300252", "name": "C0300252#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [15, 16]}}
{"token": ["The", "C0013765#ent", "<e1>", "produced", "in", "the", "absence", "of", "ascorbic", "acid", "the", "expected", "C2917660#ent", "<e2>", "composition", ",", "but", "hydroxyproline", "was", "absent", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [12, 13]}}
{"token": ["Some", "of", "these", "C0013765#ent", "<e1>", "been", "modified", "to", "contain", "lysine", ";", "this", "C2917660#ent", "<e2>", "be", "used", "for", "crosslinking", "purposes", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [12, 13]}}
{"token": ["Pit-1", "is", "a", "pituitary-specific", "transcription", "factor", "activates", "expression", "of", "the", "C1333673#ent", "<e1>", "and", "PRL", "C0017337#ent", "<e2>", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["C1333673#ent", "<e1>", "is", "evolutionarily", "coupled", "with", "other", "C0017337#ent", "<e2>", "in", "linkage", "disequilibrium", "17q24.2", ",", "and", "the", "same", "applies", "to", "IGF2", "in", "11p15.5", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}}
{"token": ["Plasma", "vasopressin", "is", "reduced", "in", "C0221043#ent", "<e1>", "but", "may", "be", "elevated", "in", "C0024588#ent", "<e2>"], "h": {"id": "C0221043", "name": "C0221043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024588", "name": "C0024588#ent", "pos": [12, 13]}}
{"token": ["Plasma", "prolactin", "level", "and", "plasma", "renin", "activity", "were", "determined", "in", "normal", "subjects", "patients", "with", "low", "and", "normal", "renin", "essential", "hypertension", "renal", "hypertension", "renovascular", "hypertension", "C0221043#ent", "<e1>", "Cushing", "syndrome", "pheochromocytoma", "and", "C0024588#ent", "<e2>"], "h": {"id": "C0221043", "name": "C0221043#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0024588", "name": "C0024588#ent", "pos": [30, 31]}}
{"token": ["The", "activity", "linked", "solvent", "molecule", "to", "zinc", "in", "the", "native", "C0014442#ent", "<e1>", "is", "displaced", "by", "all", "the", "three", "C3539179#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539179", "name": "C3539179#ent", "pos": [18, 19]}}
{"token": ["The", "antibacterial", "activity", "DDS", "has", "been", "studied", "in", "whole", "cell", "E.", "coli", ",", "cell-free", "folate", "C0014442#ent", "<e1>", "compared", "to", "effects", "obtained", "for", "C3539179#ent", "<e2>", "(", "SA", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3539179", "name": "C3539179#ent", "pos": [22, 23]}}
{"token": ["Growth", "of", "the", "heart", "in", "vivo", "be", "restrained", "by", "treatment", "with", "an", "angiotensin-converting", "enzyme", "inhibitor", "C0014025#ent", "<e1>", "maleate", ",", "or", "an", "C0521942#ent", "<e2>", "DuP", "753", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0521942", "name": "C0521942#ent", "pos": [21, 22]}}
{"token": ["Alterations", "in", "cardiac", "function", "positive", "inotropic", "effect", "isoproterenol", ",", "\u03b21-AR", "density", "isoproterenol-stimulated", "AC", "activity", "in", "the", "failing", "heart", "were", "also", "attenuated", "by", "treatment", "with", "another", "ACE", "inhibitor", "C0014025#ent", "<e1>", "and", "an", "C0521942#ent", "<e2>", "losartan", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0521942", "name": "C0521942#ent", "pos": [31, 32]}}
{"token": ["She", "was", "diagnosed", "as", "having", "severe", "pulmonary", "hypertension", "PH", ")", "complicated", "with", "primary", "Sjogren's", "syndrome", "primary", "biliary", "cirrhosis", "portal", "hypertension", "was", "treated", "with", "C0003280#ent", "<e1>", "(", "warfarin", ")", "and", "oral", "prostagrandin", "I2", "C0205911#ent", "<e2>", ")", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [32, 33]}}
{"token": ["A", "35-year-old", "man", "had", "C3854173#ent", "<e1>", "was", "subsequently", "diagnosed", "as", "having", "rhabdomyolysis", "secondary", "to", "C0017924#ent", "<e2>", "a", "primary", "myopathy", "to", "myophosphorylase", "deficiency"], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017924", "name": "C0017924#ent", "pos": [14, 15]}}
{"token": ["This", "is", "the", "only", "case", "that", "is", "known", "to", "us", "of", "C3854173#ent", "<e1>", "to", "rhabdomyolysis", "in", "a", "woman", "with", "C0017924#ent", "<e2>"], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017924", "name": "C0017924#ent", "pos": [19, 20]}}
{"token": ["We", "examined", "hepatic", "expression", "searched", "for", "extrahepatic", "expression", "of", "the", "three", "C1419799#ent", "<e1>", "mRNAs", "after", "injection", "with", "C0007332#ent", "<e2>", "or", "LPS", "."], "h": {"id": "C1419799", "name": "C1419799#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [17, 18]}}
{"token": ["These", "factors", "may", "include", "alterations", "in", "the", "degradation", "of", "C1419799#ent", "<e1>", "by", "the", "reticuloendothelial", "system", "by", "substances", "such", "as", "C0007332#ent", "<e2>", "."], "h": {"id": "C1419799", "name": "C1419799#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [19, 20]}}
{"token": ["The", "C1335554#ent", "<e1>", "encoded", "by", "mouse", "gene", "Ptprr", "PTPBR7", ",", "C1744370#ent", "<e2>", ",", "PTPPBSgamma-42", "and", "PTPPBSgamma-37", ")", "have", "been", "implicated", "in", "mitogen-activated", "protein", "MAP", ")", "kinase", "deactivation", "the", "basis", "of", "transfection", "experiments"], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1744370", "name": "C1744370#ent", "pos": [10, 11]}}
{"token": ["Plaque-forming", "phages", "the", "E.", "coli", "trp", "his", ",", "cysB", ",", "thyA", ",", "C2987231#ent", "<e1>", ",", "supE", ",", "sup", "F", "hsd", ",", "C0025965#ent", "<e2>", "and", "lig", "genes", "been", "isolated", "."], "h": {"id": "C2987231", "name": "C2987231#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0025965", "name": "C0025965#ent", "pos": [21, 22]}}
{"token": ["Cyclothiazide", "10", "microM", "reversed", "the", "action", "of", "a", "2,3-benzodiazepine", ",", "C0213386#ent", "<e1>", "which", "is", "a", "C3555655#ent", "<e2>", "but", "not", "that", "of", "the", "quinoxalinedione", ",", "NBQX", ",", "which", "is", "a", "competitive", "AMPA", "receptor", "antagonist"], "h": {"id": "C0213386", "name": "C0213386#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3555655", "name": "C3555655#ent", "pos": [15, 16]}}
{"token": ["Because", "of", "their", "early", "developmental", "stage", "eggs", "stored", "at", "147", "degree", "days", "had", "low", "hatching", "percentages", ",", "except", "eggs", "stored", "for", "3", "weeks", "in", "C1418482#ent", "<e1>", "or", "C1418482#ent", "<e1>", "plus", "C1720830#ent", "<e1>", "."], "h": {"id": "C1418482", "name": "C1418482#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1720830", "name": "C1720830#ent", "pos": [30, 31]}}
{"token": ["Furthermore", "it", "is", "unknown", "whether", "moderately", "elevated", "homocyst(e)ine", "concentrations", "per", "se", "may", "predispose", "to", "development", "of", "C0042373#ent", "<e1>", "or", "whether", "homocyst(e)ine", "is", "an", "indirect", "marker", "of", "C0007222#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [26, 27]}}
{"token": ["Erectile", "dysfunction", "represent", "a", "marker", "of", "C0042373#ent", "<e1>", "a", "predictor", "of", "the", "progression", "of", "C0007222#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [14, 15]}}
{"token": ["Advances", "in", "knowledge", "of", "the", "molecular", "genetics", "lipidaemic", "and", "C0042373#ent", "<e1>", "identified", "gene", "aberrations", "that", "are", "associated", "with", "C0007222#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [18, 19]}}
{"token": ["Transmission", "electron", "microscopy", "C1540034#ent", "<e1>", ")", "revealed", "that", "the", "cultured", "cells", "ultrastructural", "features", "consistent", "with", "of", "fetal", "C0669372#ent", "<e2>", "."], "h": {"id": "C1540034", "name": "C1540034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [17, 18]}}
{"token": ["Hoxd1", "expression", "decreased", "significantly", "in", "the", "third", "stage", "C0271889#ent", "<e1>", "development", "(", "E16-postnatal", ")", "such", "that", "only", "C1415656#ent", "<e2>", "expression", "persisted", "in", "the", "diencephalon", "of", "newborn", "mice"], "h": {"id": "C0271889", "name": "C0271889#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415656", "name": "C1415656#ent", "pos": [17, 18]}}
{"token": ["Plasma", "C3887648#ent", "<e1>", "and", "dopamine", "levels", "were", "not", "affected", "by", "treatment", "with", "C0057606#ent", "<e2>", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0057606", "name": "C0057606#ent", "pos": [12, 13]}}
{"token": ["C3900111#ent", "<e1>", "AMSAN", ")", "is", "an", "axonal", "variant", "of", "Guillian-Barr\u00e9", "syndrome", "C0018378#ent", "<e2>", ")", "that", "presents", "with", "acute", "ascending", "quadriparesis"], "h": {"id": "C3900111", "name": "C3900111#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [11, 12]}}
{"token": ["S4", "is", "encoded", "by", "one", "of", "the", "C3890009#ent", "<e1>", "(", "ribosomal", "ambiguity", ")", "C1417679#ent", "<e2>", "in", "Escherichia", "coli", "are", "the", "functional", "equivalent", "of", "omnipotent", "suppressors", "in", "yeast", "."], "h": {"id": "C3890009", "name": "C3890009#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["Some", "enteric", "strains", "of", "Escherichia", "coli", "a", "heat-stable", "enterotoxin", ",", "in", "contrast", "to", "C0008354#ent", "<e1>", "and", "heat-labile", "E.", "coli", "enterotoxins", ",", "stimulates", "guanylate", "cyclase", "C1137703#ent", "<e2>", "cyclizing", ")", ",", "EC", "4.6.1.2", ")", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1137703", "name": "C1137703#ent", "pos": [24, 25]}}
{"token": ["Importantly", ",", "C3538699#ent", "<e1>", "expression", "was", "restored", "on", "the", "surface", "of", "C1709313#ent", "<e2>", "antisense-transfected", "cells", "."], "h": {"id": "C3538699", "name": "C3538699#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [11, 12]}}
{"token": ["Our", "previous", "study", "of", "a", "group", "of", "renal", "transplant", "recipients", "treated", "with", "C0751039#ent", "<e1>", "showed", "a", "significantly", "faster", "development", "of", "C1561643#ent", "<e2>", "patients", "with", "gingival", "hyperplasia", "GH", ")", "compared", "to", "unaffected", "patients", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [20, 21]}}
{"token": ["We", "conclude", "that", "C1425433#ent", "<e1>", "helps", "to", "connect", "C3273837#ent", "<e2>", "with", "the", "endocytic", "pathway"], "h": {"id": "C1425433", "name": "C1425433#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273837", "name": "C3273837#ent", "pos": [8, 9]}}
{"token": ["These", "data", "show", "that", "C0006266#ent", "<e1>", "contributes", "significantly", "to", "the", "high", "pulmonary", "resistance", "preterm", "infants", "chronic", "lung", "disease", "that", "C0029193#ent", "<e2>", "is", "beneficial", "in", "the", "therapy", "of", "infants", "with", "chronic", "lung", "disease", "mechanical", "ventilation"], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0029193", "name": "C0029193#ent", "pos": [19, 20]}}
{"token": ["C4283949#ent", "<e1>", "a", "non-P450-dependent", "mitochondrial", "enzyme", "not", "inhibited", "while", "C0283470#ent", "<e2>", "a", "P450-dependent", "mitochondrial", "enzyme", "another", "organ", ",", "was", "blocked", "by", "ketoconazole", "."], "h": {"id": "C4283949", "name": "C4283949#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0283470", "name": "C0283470#ent", "pos": [9, 10]}}
{"token": ["This", "article", "focuses", ",", "from", "a", "practical", "clinical", "point", "view", ",", "on", "the", "laboratory", "and", "clinical", "diagnoses", "and", "treatment", "of", "pediatric", "C0037274#ent", "<e1>", "have", "specific", "antiviral", "therapies", "herpes", "virus", "infections", "including", "varicella", ")", ",", "C0950124#ent", "<e2>", "molluscum", "contagiosum"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0950124", "name": "C0950124#ent", "pos": [34, 35]}}
{"token": ["Cytochrome", "oxidase", "CCO", ")", ",", "peroxidase", ",", "C0038615#ent", "<e1>", "SDG", ")", "and", "C1824843#ent", "<e2>", "were", "studied", "electron-cytochemically", "in", "leprous", "macrophages", "LM", ")", "of", "granulomas", "of", "patients", "suffering", "from", "lepromatous", "leprosy"], "h": {"id": "C0038615", "name": "C0038615#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824843", "name": "C1824843#ent", "pos": [12, 13]}}
{"token": ["Contagious", ",", "infectious", "and", "waterborne", "diseases", "as", "diarrhoea", ",", "amoebiasis", ",", "typhoid", ",", "infectious", "hepatitis", "C0030499#ent", "<e1>", "measles", ",", "malaria", ",", "tuberculosis", ",", "C0043167#ent", "<e2>", "respiratory", "infections", "pneumonia", "and", "reproductive", "tract", "infections", "the", "morbidity", "pattern", "especially", "in", "rural", "areas"], "h": {"id": "C0030499", "name": "C0030499#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [23, 24]}}
{"token": ["This", "paper", "reviews", "current", "cytological", "and", "molecular", "knowledge", "on", "the", "C1420295#ent", "<e1>", "evolved", "to", "achieve", "chromosome", "elimination", "C0085110#ent", "<e2>", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085110", "name": "C0085110#ent", "pos": [17, 18]}}
{"token": ["Three", "types", "of", "C1420295#ent", "<e1>", "chromosome", "elimination", "events", "occur", "in", "C0085110#ent", "<e2>", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085110", "name": "C0085110#ent", "pos": [10, 11]}}
{"token": ["C0023992#ent", "<e1>", ",", "a", "mu", "opioid", "receptor", "agonist", "which", "is", "commonly", "used", "as", "an", "C0011991#ent", "<e2>", "been", "reported", "to", "possess", "analgesic", "activity", "intrathecal", "administration"], "h": {"id": "C0023992", "name": "C0023992#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [14, 15]}}
{"token": ["This", "study", "is", "to", "compare", "the", "efficacy", ",", "safety", ",", "and", "tolerability", "of", "racecadotril", "versus", "C0023992#ent", "<e1>", "in", "the", "outpatient", "treatment", "C0011991#ent", "<e2>", "adults", "."], "h": {"id": "C0023992", "name": "C0023992#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [21, 22]}}
{"token": ["Providing", "comprehensive", "care", "those", "living", "with", "C2963174#ent", "<e1>", "remains", "a", "daunting", "C0310298#ent", "<e2>", "."], "h": {"id": "C2963174", "name": "C2963174#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [11, 12]}}
{"token": ["In", "order", "to", "obtain", "large", "quantities", "of", "C1704896#ent", "<e1>", "as", "well", "as", "the", "mature", "form", "of", "human", "C1419874#ent", "<e2>", ",", "Escherichia", "coli", "expression", "plasmids", "constructed", "."], "h": {"id": "C1704896", "name": "C1704896#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419874", "name": "C1419874#ent", "pos": [17, 18]}}
{"token": ["This", "alteration", "of", "the", "lipid", "composition", "E.", "coli", "expressing", "C1419874#ent", "<e1>", "or", "C1704896#ent", "<e2>", "is", "consistent", "with", "proposed", "role", "for", "C1419874#ent", "<e1>", "in", "intracellular", "lipid", "movement"], "h": {"id": "C1704896", "name": "C1704896#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419874", "name": "C1419874#ent", "pos": [9, 10]}}
{"token": ["Here", "are", "reported", "the", "cloning", "and", "expression", "of", "a", "cDNA", "encoding", "human", "C1704896#ent", "<e1>", ",", "and", "the", "assignment", "of", "C1419874#ent", "<e2>", "human", "chromosome", "1"], "h": {"id": "C1704896", "name": "C1704896#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419874", "name": "C1419874#ent", "pos": [19, 20]}}
{"token": ["C1412626#ent", "<e1>", "is", "a", "C1412626#ent", "<e1>", "is", "essential", "for", "the", "genesis", "of", "CGC", "."], "h": {"id": "C1412626", "name": "C1412626#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412626", "name": "C1412626#ent", "pos": [0, 1]}}
{"token": ["Despite", "occasional", "statistically", "significant", "P", "=", "0.05", ")", "differences", "in", "C1705340#ent", "<e1>", "release", "with", "and", "without", "C0008783#ent", "<e2>", ",", "therapeutic", "levels", "C0008783#ent", "<e2>", "had", "no", "consistent", "effect", "on", "C1705340#ent", "<e1>", "release", "from", "pathologic", "parathyroid", "tissue", "in", "vitro"], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [16, 17]}}
{"token": ["These", "include", "epicondylitis", "at", "the", "elbow", ",", "C0151936#ent", "<e1>", "the", "wrist", "and", "C0007286#ent", "<e2>", "as", "carpal", "tunnel", "syndrome"], "h": {"id": "C0151936", "name": "C0151936#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [12, 13]}}
{"token": ["C1416670#ent", "<e1>", "a", "secreted", "C2717971#ent", "<e2>", "implicated", "in", "the", "growth", "and", "invasion", "of", "several", "human", "tumors", "."], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [4, 5]}}
{"token": ["C1416670#ent", "<e1>", "hK10", ")", "is", "a", "secreted", "C2717971#ent", "<e2>", "is", "highly", "expressed", "in", "ovarian", "tissue"], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [7, 8]}}
{"token": ["The", "normal", "epithelial", "cell-specific", "1", "(", "NES1", ")", "gene", "(", "official", "name", "kallikrein", "gene", "10", "KLK10", ")", "is", "a", "new", "member", "of", "the", "expanding", "human", "C1416670#ent", "<e1>", "encodes", "for", "a", "secreted", "C2717971#ent", "<e2>"], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [31, 32]}}
{"token": ["The", "human", "C1416670#ent", "<e1>", "one", "of", "the", "newly", "identified", "C2717971#ent", "<e2>", "to", "the", "human", "kallikrein", "family", ",", "which", "contains", "15", "members", "."], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [9, 10]}}
{"token": ["These", "results", "indicate", "that", "C1522380#ent", "<e1>", "able", "to", "C0031165#ent", "<e2>", "across", "biomembranes", "and", "serves", "as", "an", "excellent", "precursor", "for", "glutathione", "biosynthesis", "thereby", "exerting", "its", "anticataractogenic", "activity", "."], "h": {"id": "C1522380", "name": "C1522380#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031165", "name": "C0031165#ent", "pos": [8, 9]}}
{"token": ["Prolonged", "treatment", "of", "the", "cells", "with", "PDBu", "caused", "the", "down-regulation", "of", "C0033640#ent", "<e1>", "these", "cells", ",", "C0175702#ent", "<e2>", "still", "induced", "DNA", "synthesis", "the", "inhibitory", "action", "of", "TPA", "was", "abolished", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [16, 17]}}
{"token": ["C0011847#ent", "<e1>", "did", "not", "alter", "C1418457#ent", "<e2>", "(", "proEnk", ")", "expression", "in", "the", "Arc", "or", "pituitary", ",", "nor", "dynorphin", "A1", "17", "or", "beta-endorphin", "in", "paraventricular", "nucleus", "PVN", ")", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418457", "name": "C1418457#ent", "pos": [5, 6]}}
{"token": ["The", "correlation", "of", "C1439335#ent", "<e1>", "associated", "with", "LPA", "alleles", "identical", "by", "descent", "(", "C0022104#ent", "<e2>", ")", "resulted", "in", "a", "heritability", "estimate", "of", "0.801", "."], "h": {"id": "C1439335", "name": "C1439335#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [13, 14]}}
{"token": ["Conclusions-The", "present", "study", "demonstrates", "a", "race", "specific", "pattern", "of", "C0002085#ent", "<e1>", "distribution", "within", "the", "tetranucleotide", "repeat", "the", "C1417057#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417057", "name": "C1417057#ent", "pos": [17, 18]}}
{"token": ["Like", "C1704834#ent", "<e1>", ",", "the", "amino-terminal", "region", "C0058980#ent", "<e2>", "also", "interacts", "with", "the", "carboxyl-terminal", "domain", "C0058980#ent", "<e2>", "."], "h": {"id": "C1704834", "name": "C1704834#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [7, 8]}}
{"token": ["In", "contrast", ",", "dsRNA", "reduces", "the", "interaction", "of", "C1704834#ent", "<e1>", "with", "the", "carboxyl-terminal", "region", "C0058980#ent", "<e2>", "."], "h": {"id": "C1704834", "name": "C1704834#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [14, 15]}}
{"token": ["The", "amino-terminal", "region", "C0058980#ent", "<e1>", "that", "interacts", "with", "C1704834#ent", "<e2>", "contains", "a", "conserved", "DRBD", ",", "suggesting", "that", "C0058980#ent", "<e1>", "can", "form", "nonfunctional", "heterodimers", "with", "C1704834#ent", "<e2>", ",", "analogous", "to", "those", "seen", "with", "other", "dsRNA", "binding", "proteins"], "h": {"id": "C1704834", "name": "C1704834#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [3, 4]}}
{"token": ["The", "generation", "of", "these", "messengers", "is", "regulated", "primarily", "by", "two", "different", "types", "of", "C0031671#ent", "<e1>", ",", "phospholipase", "C", "PLC", ")", "and", "C0031667#ent", "<e2>", "PLA2", ")", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [13, 14]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [21, 22]}}
{"token": ["The", "generation", "of", "these", "messengers", "is", "regulated", "primarily", "by", "two", "different", "types", "of", "phospholipases", ",", "C0031671#ent", "<e1>", "PLC", ")", "and", "phospholipase", "A2", "C0031667#ent", "<e2>", ")", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [15, 16]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [22, 23]}}
{"token": ["We", "herein", "show", "the", "up-regulation", "of", "MMP-1", "(", "interstitial", "collagenase", "and", "MMP-3", "(", "stromelysin", ")", "mRNAs", "of", "cultured", "synovial", "fibroblasts", "from", "rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "patients", "in", "response", "to", "macrophage", "migration", "inhibitory", "factor", "C1334507#ent", "<e2>", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [23, 24]}, "relation": "disease_has_associated_gene", "t": {"id": "C1334507", "name": "C1334507#ent", "pos": [34, 35]}}
{"token": ["We", "herein", "show", "the", "up-regulation", "of", "MMP-1", "(", "interstitial", "collagenase", "and", "MMP-3", "(", "stromelysin", ")", "mRNAs", "of", "cultured", "synovial", "fibroblasts", "from", "C0003873#ent", "<e1>", "RA", ")", "patients", "in", "response", "to", "macrophage", "migration", "inhibitory", "factor", "C1334507#ent", "<e2>", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}, "relation": "disease_has_associated_gene", "t": {"id": "C1334507", "name": "C1334507#ent", "pos": [33, 34]}}
{"token": ["BPES", "is", "a", "rare", "autosomal", "dominant", "congenital", "disorder", "characterized", "by", "the", "eponymous", "oculo-facial", "features", "that", "are", ",", "in", "female", "patients", ",", "associated", "either", "(", "C0220663#ent", "<e1>", "or", "without", "(", "type", "2", "BPES", "C0085215#ent", "<e2>"], "h": {"id": "C0220663", "name": "C0220663#ent", "pos": [24, 25]}, "relation": "has_manifestation", "t": {"id": "C0085215", "name": "C0085215#ent", "pos": [32, 33]}}
{"token": ["Substantial", "evidence", "supports", "the", "suggestion", "that", "C1334485#ent", "<e1>", "Csk", ")", "and", "C0250935#ent", "<e2>", "CHK", ")", ",", "two", "negative", "regulatory", "kinases", "the", "Src", "tyrosine", "kinase", "family", "play", "distinct", "roles", "during", "development", "of", "the", "central", "nervous", "system", "CNS", ")", "."], "h": {"id": "C1334485", "name": "C1334485#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0250935", "name": "C0250935#ent", "pos": [11, 12]}}
{"token": ["The", "C1334485#ent", "<e1>", "CHK", ")", ",", "formerly", "C0250935#ent", "<e2>", ",", "is", "a", "tyrosine", "kinase", "contains", "the", "Src", "homology", "2", "3", "(", "SH2", "and", "SH3)", "domains", "demonstrates", "homology", "(", "approximately", "50", "%", ")", "to", "the", "Csk", "tyrosine", "kinase"], "h": {"id": "C1334485", "name": "C1334485#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0250935", "name": "C0250935#ent", "pos": [7, 8]}}
{"token": ["Response", "to", "pollution", "charges", "were", "analyzed", "by", "reverse", "transcriptase-PCR", "heat-shock", "protein", "hsp70", ")", ",", "P-glycoprotein", "(", "P-gp", ")", ",", "C1413138#ent", "<e1>", "(", "CAT", ")", "and", "C0537086#ent", "<e2>", "piGST", ")", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [25, 26]}}
{"token": ["Antioxidant", "defense", "measured", "by", "the", "activities", "of", "superoxide", "dismutase", "SOD", ")", ",", "C1413138#ent", "<e1>", "(", "CAT", ")", ",", "ascorbate", "peroxidase", "APOX", ")", "and", "C0537086#ent", "<e2>", "GSTpx", ")", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [23, 24]}}
{"token": ["Phospholipase", "A2", "C0031667#ent", "<e1>", ")", "is", "the", "main", "C3274161#ent", "<e2>", "of", "hymenopteran", "venoms"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [8, 9]}}
{"token": ["Degradation", "products", "of", "phospholipase", "A2", "C0031667#ent", "<e1>", ")", ",", "the", "major", "C3274161#ent", "<e2>", "of", "honeybee", "venom", "were", "prepared", "by", "peptic", "digestion", "the", "enzyme", "and", "fractionated", "by", "molecular", "exclusion", "chromatography"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [11, 12]}}
{"token": ["C0031667#ent", "<e1>", "PLA", ")", "is", "the", "major", "C3274161#ent", "<e2>", "in", "bee", "sting", "allergy"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "the", "noncovalent", "binding", "of", "C0014963#ent", "<e1>", "the", "protein", "modifies", "the", "binding", "properties", "of", "the", "C1412332#ent", "<e2>", "."], "h": {"id": "C0014963", "name": "C0014963#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "C1307407#ent", "<e1>", "and", "SGK1", "cooperate", "in", "the", "stimulation", "of", "the", "intestinal", "phosphate", "transporter", "C1420186#ent", "<e2>", "."], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420186", "name": "C1420186#ent", "pos": [16, 17]}}
{"token": ["The", "present", "experiments", "explored", "whether", "C1307407#ent", "<e1>", "regulates", "the", "activity", "of", "C1420186#ent", "<e2>", "."], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420186", "name": "C1420186#ent", "pos": [11, 12]}}
{"token": ["Five", "elderly", "men", "with", "C0024141#ent", "<e1>", "were", "initially", "seen", "with", "a", "C0442893#ent", "<e2>", "marked", "by", "fever", ",", "weight", "loss", "and", "arthritis", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [11, 12]}}
{"token": ["We", "present", "a", "23-year-old", "man", "with", "C0024141#ent", "<e1>", ",", "who", "developed", "a", "bullous", "eruption", "associated", "with", "flare", "of", "the", "C0442893#ent", "<e2>"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [19, 20]}}
{"token": ["Systemic", "lupus", "erythematosus", "C0024141#ent", "<e1>", ")", "is", "a", "C0442893#ent", "<e2>", "by", "alterations", "in", "the", "regulation", "of", "both", "cellular", "and", "humoral", "immune", "responses"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [8, 9]}}
{"token": ["Significantly", "increased", "anti-MDA-modified", "epitope(s", ")", "autoantibodies", "were", "found", "in", "patients", "with", "C0024141#ent", "<e1>", "and", "also", "in", "other", "C0442893#ent", "<e2>", "as", "PAN", "and", "SCL", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [17, 18]}}
{"token": ["Phosphorylation", "of", "myosin", "regulatory", "light", "chain", "be", "mediated", "directly", "and", "indirectly", "by", "several", "C0031727#ent", "<e1>", "including", "C0027120#ent", "<e2>", "MLCK", ")", "and", "C0031727#ent", "<e1>", "activated", "by", "small", "GTP-binding", "proteins"], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [16, 17]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["However", ",", "pretraining", "bilateral", "intracerebral", "injections", "of", "1.25", "pmole/hemisphere", "omega-conotoxin", "C1706170#ent", "<e1>", "produced", "amnesia", "for", "the", "passive", "avoidance", "C0310298#ent", "<e2>", "in", "chicks", "tested", "30", "min", "or", "3", "h", "after", "training", "."], "h": {"id": "C1706170", "name": "C1706170#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [18, 19]}}
{"token": ["The", "release", "of", "C1705556#ent", "<e1>", "by", "Ang", "II", "suppressed", "by", "10", "microM", "SC52458", ",", "an", "C0019593#ent", "<e2>", "not", "by", "10", "microM", "PD123319", ",", "an", "AT2", "receptor", "antagonist"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [15, 16]}}
{"token": ["The", "potential", "presence", "in", "some", "animals", "but", "not", "others", "of", "an", "C0027203#ent", "<e1>", "which", "can", "rapidly", "hydrolyse", "compounds", "such", "as", "C1161352#ent", "<e2>", "is", "a", "potential", "unwanted", "experimental", "variable", "in", "many", "experiments", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [20, 21]}}
{"token": ["This", "study", "focused", "on", "the", "rat", "3H3", "T", "cell", "that", "recognized", "guinea", "pig", "(", "GP", ")", "C1417057#ent", "<e1>", "as", "a", "full", "C0243192#ent", "<e2>", "and", "self", "rat", "R", ")", "C1417057#ent", "<e1>", "as", "a", "partial", "C0243192#ent", "<e2>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1417057", "name": "C1417057#ent", "pos": [16, 17]}}
{"token": ["P.", "aeruginosa", "activate", "p38", "and", "p42/44", "kinases", ",", "and", "inhibition", "of", "these", "kinases", "partly", "prevented", "3O-C(12)-HSL-induced", "changes", "in", "C1415273#ent", "<e1>", ",", "paracellular", "flux", "and", "expression", "of", "C1417928#ent", "<e2>", "and", "ZO-1", "."], "h": {"id": "C1415273", "name": "C1415273#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417928", "name": "C1417928#ent", "pos": [26, 27]}}
{"token": ["In", "T84", "cells", ",", "BiCM", "increased", "C1415273#ent", "<e1>", ",", "decreased", "claudin-2", ",", "and", "increased", "ZO-1", "and", "C1417928#ent", "<e2>", "expression", "."], "h": {"id": "C1415273", "name": "C1415273#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417928", "name": "C1417928#ent", "pos": [16, 17]}}
{"token": ["The", "AMPA", "receptor", "subunits", ",", "GluR-B", "and", "C1704949#ent", "<e1>", ",", "and", "the", "NMDA", "receptor", "subunits", "C3273845#ent", "<e2>", "and", "NR2B", "were", "found", "to", "be", "abundantly", "expressed", "in", "all", "CA1", "pyramidal", "neurones", "tested", "."], "h": {"id": "C1704949", "name": "C1704949#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273845", "name": "C3273845#ent", "pos": [15, 16]}}
{"token": ["Finally", ",", "sequence", "comparisons", "that", "the", "intronless", "equine", "PGK2", "gene", "the", "C1418508#ent", "<e1>", "located", "approximately", "39", "kb", "downstream", "of", "C1826315#ent", "<e2>", "."], "h": {"id": "C1418508", "name": "C1418508#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1826315", "name": "C1826315#ent", "pos": [19, 20]}}
{"token": ["This", "study", "has", "shown", "that", ",", "compared", "to", "sucralfate", "suspension", ",", "C0038633#ent", "<e1>", "longer", "in", "the", "stomach", "of", "patients", "with", "C0017152#ent", "<e2>", "and", "peptic", "ulcer"], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [20, 21]}}
{"token": ["The", "efficacy", "of", "C0038633#ent", "<e1>", "in", "the", "treatment", "of", "patients", "with", "dyspepsia", "and", "macroscopic", "signs", "C0017152#ent", "<e2>", "was", "assessed", "in", "a", "double-blind", ",", "placebo-controlled", "study"], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [15, 16]}}
{"token": ["The", "binding", "moiety", "of", "C0038633#ent", "<e1>", "to", "gastric", "mucosal", "sites", "such", "as", "gastric", "ulcers", "areas", "of", "C0017152#ent", "<e2>", ",", "was", "studied", "in", "humans", "."], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [16, 17]}}
{"token": ["As", "sulfated", "molecules", "are", "common", "C0127400#ent", "<e1>", "of", "cell-cell", "interactions", "the", "sulfotransferases", "and", "C0038717#ent", "<e2>", "may", "be", "involved", "in", "regulating", "host-pathogen", "interactions"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038717", "name": "C0038717#ent", "pos": [13, 14]}}
{"token": ["Lastly", ",", "increased", "glomerular", "IL-4", "in", "nephrotoxic", "nephritis", "inhibits", "infiltrating", "macrophages", "from", "expressing", "C1426212#ent", "<e1>", "and", "was", "associated", "with", "attenuated", "C0268731#ent", "<e2>"], "h": {"id": "C1426212", "name": "C1426212#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [20, 21]}}
{"token": ["One", "candidate", "VL", "domain-specific", "for", "C1366561#ent", "<e1>", "was", "affinity", "matured", "by", "simultaneous", "randomisation", "of", "all", "C0055351#ent", "<e2>", "loops", "using", "DNA", "shuffling", "degenerate", "CDR-spiking", "oligonucleotides", "."], "h": {"id": "C1366561", "name": "C1366561#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0055351", "name": "C0055351#ent", "pos": [15, 16]}}
{"token": ["The", "extracellular", "domain", "C0085151#ent", "<e1>", "APP", ")", "contains", "an", "inhibitor", "against", "C0172537#ent", "<e2>", "MMP-2", ",", "gelatinase", "A", "."], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [11, 12]}}
{"token": ["C0011522#ent", "<e1>", "from", "several", "C0085423#ent", "<e2>", "hybridized", "to", "a", "probe", "containing", "bkdR", ",", "indicating", "the", "presence", "of", "bkdR-like", "genes", "in", "these", "organisms", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [4, 5]}}
{"token": ["Accompanying", "the", "changes", "observed", "in", "immunoblots", ",", "CYP1A1", "and", "C3814396#ent", "<e1>", "mRNA", "levels", "were", "increased", "by", "C1822658#ent", "<e2>", "in", "a", "dose-dependent", "manner", "and", "also", "increased", "additively", "in", "combination", "with", "FO", "feeding", "."], "h": {"id": "C3814396", "name": "C3814396#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1822658", "name": "C1822658#ent", "pos": [16, 17]}}
{"token": ["Haemophilus", "influenzae", "type", "b", "C0018482#ent", "<e1>", ")", "is", "an", "important", "cause", "of", "invasive", "C0004623#ent", "<e2>", "children", ",", "including", "meningitis", "and", "pneumonia", "."], "h": {"id": "C0018482", "name": "C0018482#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [13, 14]}}
{"token": ["Young", "Caucasian", "children", "of", "the", "low", "responder", "phenotype", ",", "i.e.", ",", "those", "lacking", "the", "G2m(n", ")", "allotype", ",", "are", "genetically", "predisposed", "to", "C0018482#ent", "<e1>", "and", "perhaps", "other", "C0004623#ent", "<e2>"], "h": {"id": "C0018482", "name": "C0018482#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [27, 28]}}
{"token": ["Haemophilus", "influenzae", "type", "b", "C0018482#ent", "<e1>", ")", "is", "a", "major", "cause", "of", "serious", "C0004623#ent", "<e2>", "early", "childhood"], "h": {"id": "C0018482", "name": "C0018482#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [13, 14]}}
{"token": ["Based", "on", "the", "low", "therapeutic", "efficiency", "of", "C1538586#ent", "<e1>", "other", "dithiols", "were", "developed", "and", "DMSA", "(", "meso-2,3-dimercaptosuccinic", "acid", "and", "C0041738#ent", "<e2>", "(", "2,3-dimercaptopropane-1-sulfonic", "acid", "are", "becoming", "used", "for", "treatments", "of", "humans", "exposed", "to", "heavy", "metals"], "h": {"id": "C1538586", "name": "C1538586#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041738", "name": "C0041738#ent", "pos": [19, 20]}}
{"token": ["Treatment", "may", "incklude", "the", "use", "of", "chelating", "agents", "as", "dimercaprol", "(", "C1538586#ent", "<e1>", ")", ",", "dimercaptosuccinic", "acid", "DMSA", ")", ",", "and", "C0041738#ent", "<e2>", "DMPS", ")", "."], "h": {"id": "C1538586", "name": "C1538586#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041738", "name": "C0041738#ent", "pos": [21, 22]}}
{"token": ["AD1", "is", "a", "binding", "site", "the", "related", "coactivators", "cAMP-response", "element", "binding", "protein", "binding", "protein", "CBP", ")", "and", "C1705458#ent", "<e1>", ",", "whereas", "AD2", "binds", "to", "another", "coactivator", ",", "C1428067#ent", "<e2>", "CARM1", ")", ",", "a", "protein-arginine", "methyltransferase"], "h": {"id": "C1705458", "name": "C1705458#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1428067", "name": "C1428067#ent", "pos": [27, 28]}}
{"token": ["c-Abl", "(", "v-Abl", "Abelson", "murine", "leukemia", "viral", "oncogene", "homolog", "1", "tyrosine", "kinase", "phosphorylates", "AIB1/SRC-3", "at", "Y1357", "and", "modulates", "the", "association", "of", "AIB1", "with", "c-Abl", ",", "ERalpha", ",", "the", "transcriptional", "cofactor", "C1705458#ent", "<e1>", ",", "and", "the", "C1428067#ent", "<e2>", "CARM1", "."], "h": {"id": "C1705458", "name": "C1705458#ent", "pos": [30, 31]}, "relation": "NA", "t": {"id": "C1428067", "name": "C1428067#ent", "pos": [35, 36]}}
{"token": ["We", "delineate", "a", "C1335239#ent", "<e1>", "CXCL", ")", "12-dependent", "pathway", "of", "TGF-beta-induced", "C1418943#ent", "<e2>", "migration", "that", "is", "facilitated", "by", "MMP-9-mediated", "stem", "cell", "factor", "cleavage", "in", "vitro"], "h": {"id": "C1335239", "name": "C1335239#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [11, 12]}}
{"token": ["No", "such", "stimulation", "occurs", "in", "response", "to", "C1335239#ent", "<e1>", "or", "thrombospondin", ",", "or", "when", "C1418943#ent", "<e2>", "its", "gamma-carboxyglutamic", "acid", "Gla", ")", "domain", "is", "the", "substrate", "."], "h": {"id": "C1335239", "name": "C1335239#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [14, 15]}}
{"token": ["Hyperthyroidism", "may", "present", "various", "C0026848#ent", "<e1>", "namely", "thyrotoxic", "chronic", "myopathy", ",", "C0026896#ent", "<e2>", "disthyroid", "ophthalmopathy", "thyrotoxic", "periodic", "paralysis"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [11, 12]}}
{"token": ["Elevated", "levels", "were", "found", "in", "93", "%", "of", "patients", "with", "C0026848#ent", "<e1>", "in", "54", "%", "with", "C0026896#ent", "<e2>", "in", "50", "%", "with", "neurogenic", "myopathy"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [16, 17]}}
{"token": ["Two", "children", "(", "who", "had", "had", "neonatal", "C0026896#ent", "<e1>", "had", "a", "moderate", "C0026848#ent", "<e2>", "probably", "unrelated", "to", "the", "C0026896#ent", "<e1>", "their", "mother", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [7, 8]}}
{"token": ["C0026848#ent", "<e1>", ",", "especially", "polymyositis", ",", "and", "C0026896#ent", "<e2>", "potentially", "treatable", "disorders", "that", "must", "be", "considered", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [7, 8]}}
{"token": ["Felodipine", ",", "but", "not", "C0072973#ent", "<e1>", ",", "concentration-dependently", "inhibited", "cytokine-induced", "NO", "production", "and", "C1538973#ent", "<e2>", "NOS", ")", "mRNA", "induction", "."], "h": {"id": "C0072973", "name": "C0072973#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1538973", "name": "C1538973#ent", "pos": [13, 14]}}
{"token": ["These", "results", "are", "consistent", "with", "hypothesis", "that", "association", "or", "uptake", "of", "C1442758#ent", "<e1>", "by", "type", "II", "cells", "be", "enhanced", "by", "C1420002#ent", "<e2>", "and", "that", "like", "C1420002#ent", "<e2>", ",", "C1442758#ent", "<e1>", "is", "recycled", "by", "type", "II", "cells"], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [20, 21]}}
{"token": ["Purified", "anti-human", "RBC", "C1414528#ent", "<e1>", "fusion", "proteins", "containing", "sequences", "derived", "from", "HIV-1", "gp41", "and", "C1826560#ent", "<e2>", "highly", "specific", "for", "detection", "of", "antibodies", "to", "HIV-1", "and", "HIV-2", ",", "respectively", "."], "h": {"id": "C1414528", "name": "C1414528#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1826560", "name": "C1826560#ent", "pos": [14, 15]}}
{"token": ["A", "new", "method", "for", "the", "determination", "of", "pentachlorophenol", "(", "C0031381#ent", "<e1>", ")", "in", "different", "foods", "was", "developed", "using", "capillary", "gas", "chromatography", "C3537453#ent", "<e2>", ")", "and", "microwave", "induced-plasma", "atomic", "emission", "spectrometry", "(", "MIP-AED", ")", "."], "h": {"id": "C0031381", "name": "C0031381#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3537453", "name": "C3537453#ent", "pos": [21, 22]}}
{"token": ["Conventional", "sporadic", "adenomas", "in", "C0031269#ent", "<e1>", "patients", "will", "similarly", "show", "C0034888#ent", "<e2>", "carry", "the", "associated", "histological", "features", "."], "h": {"id": "C0031269", "name": "C0031269#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0034888", "name": "C0034888#ent", "pos": [10, 11]}}
{"token": ["In", "vitro", "ceramide", "specifically", "bound", "to", "the", "purified", "catalytic", "domain", "enhanced", "association", "with", "activated", "C0242853#ent", "<e1>", "but", "did", "not", "affect", "the", "kinase", "activity", "C1706586#ent", "<e2>", "."], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [23, 24]}}
{"token": ["Mammalian", "C0242853#ent", "<e1>", "multiple", "effectors", "including", "C1706586#ent", "<e2>", ",", "Ral", "guanine", "nucleotide", "dissociation", "stimulator", "RalGDS", ")", ",", "and", "phosphoinositide", "3-kinase"], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [6, 7]}}
{"token": ["Here", "we", "purify", "and", "characterize", "the", "multiple", "DNA", "ligase", "enzymes", "of", "mycobacteria", "and", "probe", "C1516876#ent", "<e1>", "whether", "the", "C0101555#ent", "<e2>", "required", "for", "growth", "of", "M.", "tuberculosis"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [18, 19]}}
{"token": ["Of", "note", ",", "C1416496#ent", "<e1>", "served", "as", "a", "potent", "T", "and", "B", "cell", "antigen", "both", "C0149512#ent", "<e2>", "convalescence", "."], "h": {"id": "C1416496", "name": "C1416496#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [15, 16]}}
{"token": ["To", "evaluate", "carbamezapine", "(", "C0006949#ent", "<e1>", ")", "for", "neuritic", "pain", "in", "Guillain-Barr\u00e9", "syndrome", "C0018378#ent", "<e2>", ")", "patients", "in", "the", "intensive", "care", "unit", "ICU", ")", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "support", "C1414397#ent", "<e1>", "as", "a", "C0019247#ent", "<e2>", "and", "shed", "new", "light", "on", "the", "molecular", "mechanism", "the", "disease", "and", "to", "the", "function", "of", "the", "enamelin", "protein", "enamel", "formation"], "h": {"id": "C1414397", "name": "C1414397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["Porphyromonas", "gingivalis", "a", "bacterium", "implicated", "in", "the", "pathogenesis", "of", "C0017563#ent", "<e1>", "was", "found", "to", "elaborate", "an", "extracellular", "glycosulfatase", "C0027203#ent", "<e2>", "."], "h": {"id": "C0017563", "name": "C0017563#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["C0242383#ent", "<e1>", "AMD", ")", "is", "one", "of", "the", "most", "common", "C0015397#ent", "<e2>", "elderly", "individuals", "."], "h": {"id": "C0242383", "name": "C0242383#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [10, 11]}}
{"token": ["Ca2", "+", "-calmodulin-dependent", "phosphorylation", "of", "C0027120#ent", "<e1>", "the", "catalytic", "COOH-terminal", "half", "of", "C1334539#ent", "<e2>", "MLCK", ")", "activates", "myosin", "II", "smooth", "and", "nonmuscle", "cells"], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [12, 13]}}
{"token": ["A", "method", "has", "been", "developed", "for", "measuring", "the", "level", "of", "phosphorylation", "of", "C0027120#ent", "<e1>", "MLC2", ")", "by", "the", "endogenous", "C1334539#ent", "<e2>", "mechanically", "skinned", "skeletal", "muscle", "fibres"], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [19, 20]}}
{"token": ["ONS", "and/or", "C1333522#ent", "<e1>", "in", "addition", "to", "normal", "food", "indicated", "in", "C0162429#ent", "<e2>", "patients", "with", "IBD", "to", "improve", "nutritional", "status", "quality", "of", "life"], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [11, 12]}}
{"token": ["Capillary", "electrophoretic", "estimation", "apparent", "binding", "constants", "(", "Kapp", ")", "for", "C0027396#ent", "<e1>", ",", "salbutamol", ",", "indomethacine", "and", "C0033216#ent", "<e2>", "with", "beta-cyclodextrin", "is", "presented", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [17, 18]}}
{"token": ["In", "obese", "humans", "and", "rodents", "there", "is", "increased", "expression", "of", "the", "key", "glucocorticoid", "(", "C3537453#ent", "<e1>", ")", "regenerating", "enzyme", ",", "11beta-hydroxysteroid", "dehydrogenase", "type", "1", "C3715112#ent", "<e2>", ")", ",", "in", "adipose", "tissue"], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3715112", "name": "C3715112#ent", "pos": [24, 25]}}
{"token": ["The", "beneficial", "metabolic", "actions", "of", "peroxisome", "proliferator-activated", "receptor", "gamma", "PPARgamma", ")", "agonism", "are", "associated", "with", "modifications", "in", "adipose", "tissue", "metabolism", "that", "include", "a", "reduction", "in", "local", "glucocorticoid", "C3537453#ent", "<e1>", ")", "production", "by", "11beta-hydroxysteroid", "dehydrogenase", "type", "1", "C3715112#ent", "<e2>", ")", "."], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C3715112", "name": "C3715112#ent", "pos": [36, 37]}}
{"token": ["Further", ",", "food", "restriction", "affect", "the", "efficiency", "of", "local", "C3537453#ent", "<e1>", "effects", "by", "altering", "GR", "and", "C3715112#ent", "<e2>", "mRNA", "expression", "."], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3715112", "name": "C3715112#ent", "pos": [16, 17]}}
{"token": ["Second", ",", "we", "investigated", "the", "role", "of", "C1979930#ent", "<e1>", "MAP", ")", "kinases", ",", "and", "the", "C1367731#ent", "<e2>", "JNK", ")", "in", "particular", ",", "as", "a", "mediator", "of", "this", "response", "."], "h": {"id": "C1979930", "name": "C1979930#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [15, 16]}}
{"token": ["The", "C0084340#ent", "<e1>", "binding", "to", "myosin", "IXb", "inhibited", "by", "the", "addition", "of", "C1413561#ent", "<e2>", "with", "the", "concentration", "similar", "to", "the", "inhibition", "of", "the", "GAP", "activity", "."], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413561", "name": "C1413561#ent", "pos": [12, 13]}}
{"token": ["There", "are", "two", "major", "syndromes", "presenting", "in", "the", "early", "decades", "life", "with", "C0393593#ent", "<e1>", "and", "parkinsonism", ":", "dopa-responsive", "dystonia", "DRD", ")", "and", "C2677567#ent", "<e2>", "EOIP", ")", "."], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C2677567", "name": "C2677567#ent", "pos": [22, 23]}}
{"token": ["The", "authors", "reported", "a", "case", "of", "clinical", "application", "midazolam", ":", "a", "C0038220#ent", "<e1>", "successfully", "treated", "with", ",", "while", "intravenous", "C0012010#ent", "<e2>", "of", "30", "mg", "failed", "to", "control", "the", "status", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [19, 20]}}
{"token": ["C0759338#ent", "<e1>", "inhibits", "farnesylation", "of", "C0034678#ent", "<e2>", "and", "other", "proteins", "in", "tumor", "cells", "suppresses", "tumor", "growth", "human", "xenograft", "and", "transgenic", "mouse", "cancer", "models", "in", "vivo"], "h": {"id": "C0759338", "name": "C0759338#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [5, 6]}}
{"token": ["Ras-mediated", "signal", "transduction", "has", "been", "targeted", "using", "inhibitors", "of", "farnesyl", "transferase", "R115777", "and", "C0759338#ent", "<e1>", ")", "to", "block", "the", "post-translation", "modification", "of", "C0034678#ent", "<e2>", "."], "h": {"id": "C0759338", "name": "C0759338#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [22, 23]}}
{"token": ["C0088353#ent", "<e1>", "found", "to", "be", "responsible", "for", "the", "intracellular", "mobilization", "of", "C2936886#ent", "<e2>", "."], "h": {"id": "C0088353", "name": "C0088353#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "these", "biochemical", "and", "flow", "cytometric", "methodologies", "can", "be", "used", "to", "analyse", "signal-induced", "changes", "in", "phosphatidylinositol", "bisphosphate", "levels", ",", "diacylglycerol", "and", "C0088353#ent", "<e1>", "production", "and", "C2936886#ent", "<e2>", "in", "each", "B", "cell", "population"], "h": {"id": "C0088353", "name": "C0088353#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [26, 27]}}
{"token": ["In", "this", "study", "we", "altered", "the", "positional", "specificity", "the", "human", "C0003693#ent", "<e1>", "by", "multiple", "site-directed", "mutagenesis", "assayed", "the", "C0003693#ent", "<e1>", "activity", "of", "the", "mutant", "enzyme", "species", "(5S,6E,8Z,11Z,14Z)-5-hydroperoxy-6,8,11,14-eicos", "atetraenoic", "acid", "(", "5S-HpETE", ")", "as", "substrate", "."], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [10, 11]}}
{"token": ["Fourteen", "patients", "with", "monosymptomatic", "delusions", "of", "C0851341#ent", "<e1>", "were", "followed-up", "19", "-", "48", "months", "after", "treatment", "with", "C0031935#ent", "<e2>", "was", "terminated", "."], "h": {"id": "C0851341", "name": "C0851341#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [17, 18]}}
{"token": ["Of", "all", "the", "storage", "diseases", "C0026703#ent", "<e1>", "is", "the", "one", "whose", "C0029166#ent", "<e2>", "probably", "the", "least", "well", "known", "."], "h": {"id": "C0026703", "name": "C0026703#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [11, 12]}}
{"token": ["This", "role", "of", "Cdc5", "(", "C1335227#ent", "<e1>", "in", "regulating", "C1705268#ent", "<e2>", "is", "likely", "to", "be", "relevant", "to", "cytokinesis", "and", "asymmetric", "cell", "division", "other", "organisms", "."], "h": {"id": "C1335227", "name": "C1335227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705268", "name": "C1705268#ent", "pos": [9, 10]}}
{"token": ["C1384543#ent", "<e1>", "is", "a", "C1335554#ent", "<e2>", "PTP", ")", "predominantly", "expressed", "in", "haematopoietic", "cells", "containing", "two", "src", "homology-2", "(", "SH2", ")", "domains", "."], "h": {"id": "C1384543", "name": "C1384543#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [4, 5]}}
{"token": ["Studies", "on", "several", "of", "these", "proteins", ",", "including", "C1384543#ent", "<e1>", "the", "c-cbl", "proto-oncogene", "product", ",", "and", "C1335554#ent", "<e2>", "discussed", "."], "h": {"id": "C1384543", "name": "C1384543#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "the", "efficacy", "of", "a", "fluoride", "dentifrice", "a", "fixed", "combination", "of", "essential", "oils", "C0040096#ent", "<e1>", ",", "Menthol", ",", "Eucalyptol", ",", "and", "Methyl", "Salicylate", "in", "preventing", "C0333519#ent", "<e2>", "in", "Sprague", "Dawley", "rats"], "h": {"id": "C0040096", "name": "C0040096#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0333519", "name": "C0333519#ent", "pos": [26, 27]}}
{"token": ["Moreover", ",", "a", "variety", "of", "therapeutic", "genes", "direct", "antitumor", "effects", "as", "those", "encoding", "proapoptotic", "proteins", "p53", "E1A", ",", "p202", ",", "C1333362#ent", "<e1>", ",", "BAX", ",", "Bik", ",", "and", "prodrug", "metabolizing", "C3541394#ent", "<e2>", ",", "namely", "thymidine", "kinase", "cytosine", "deaminase"], "h": {"id": "C1333362", "name": "C1333362#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [30, 31]}}
{"token": ["C1333362#ent", "<e1>", "also", "activates", "transcription", "of", "genes", "encoding", "matrix-degrading", "proteinases", ",", "C3541394#ent", "<e2>", "required", "for", "tumor", "cell", "migration", "invasion", "."], "h": {"id": "C1333362", "name": "C1333362#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["Human", "C0282527#ent", "<e1>", "PBDs", ")", ",", "such", "as", "Zellweger", "syndrome", "comprise", "13", "different", "C0004135#ent", "<e2>", "CGs", ")", "."], "h": {"id": "C0282527", "name": "C0282527#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [13, 14]}}
{"token": ["Since", "cardiac", "tissue", "C0007427#ent", "<e1>", "a", "lysosomal", "enzyme", "of", "renin-like", "activity", ",", "a", "rat", "C1332805#ent", "<e2>", "also", "developed", "to", "assess", "C0007427#ent", "<e1>", "to", "renin-like", "activity", "."], "h": {"id": "C0007427", "name": "C0007427#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332805", "name": "C1332805#ent", "pos": [14, 15]}}
{"token": ["Both", "C0011816#ent", "<e1>", "and", "C1413693#ent", "<e2>", "inhibited", "TNF", "production", ",", "whereas", "induction", "of", "IL-1", "and", "IL-6", "was", "inhibited", "by", "C0011816#ent", "<e1>", "but", "not", "by", "C1413693#ent", "<e2>", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413693", "name": "C1413693#ent", "pos": [4, 5]}}
{"token": ["We", "have", "tested", "the", "effect", "of", "dexamethasone", "(", "C0011816#ent", "<e1>", ")", "and", "chlorpromazine", "(", "C1413693#ent", "<e2>", ")", "on", "the", "lethal", "effect", "of", "IL-1", ",", "TNF", "and", "endotoxin", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413693", "name": "C1413693#ent", "pos": [14, 15]}}
{"token": ["Stress", "increased", "open", "field", "activity", "of", "ADX", "offspring", "but", "decreased", "the", "activity", "of", "C0011816#ent", "<e1>", "offspring", "while", "the", "performance", "of", "CON", "and", "C1413693#ent", "<e2>", "offspring", "was", "not", "affected", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413693", "name": "C1413693#ent", "pos": [22, 23]}}
{"token": ["The", "C1254351#ent", "<e1>", "increased", "the", "background", "K", "current", "(", "C1825588#ent", "<e2>", ")", "and", "did", "not", "alter", "the", "time-dependent", "K", "current", "(", "Ix1", ")", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1825588", "name": "C1825588#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "role", "of", "NO", "in", "the", "C1414672#ent", "<e1>", "of", "diaphragmatic", "dysfunction", "during", "C0243026#ent", "<e2>", "."], "h": {"id": "C1414672", "name": "C1414672#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [20, 21]}}
{"token": ["C1161320#ent", "<e1>", "DNA", "transfections", "AT2.1", "cells", "were", "performed", "with", "the", "v-H-ras", "C1417123#ent", "<e2>", "or", "with", "control", "DNA"], "h": {"id": "C1161320", "name": "C1161320#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [11, 12]}}
{"token": ["We", "have", "investigated", "linkage", "to", "five", "regions", "C1512488#ent", "<e1>", "to", "those", "identified", "in", "animal", "models", "C0003864#ent", "<e2>", "RA", "affected", "sibling", "pair", "ASP", ")", "families", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "Y27632", ",", "abolished", "p44(mapk)", "C1705524#ent", "<e1>", ")", "but", "had", "no", "effect", "p42(mapk)", "ERK2", ")", "or", "C1366876#ent", "<e2>", "."], "h": {"id": "C1705524", "name": "C1705524#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [18, 19]}}
{"token": ["Collectively", ",", "these", "results", "imply", "a", "critical", "role", "for", "C1705524#ent", "<e1>", "and", "JNK1", "but", "not", "C1366876#ent", "<e2>", "in", "VES-induced", "apoptosis", "of", "human", "MDA-MB-435", "breast", "cancer", "cells"], "h": {"id": "C1705524", "name": "C1705524#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [15, 16]}}
{"token": ["Expression", "of", "dominant", "negative", "mutants", "of", "C1705524#ent", "<e1>", ",", "MAPK/ERK", "activator-1", "or", "JNK1", "but", "not", "C1366876#ent", "<e2>", "blocked", "phosphorylation", "of", "the", "substrate", "glutathione", "and", "inhibited", "VES-induced", "apoptosis", "."], "h": {"id": "C1705524", "name": "C1705524#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [15, 16]}}
{"token": ["C1426212#ent", "<e1>", "increased", "at", "4", "and", "24", "h", "after", "thermal", "injury", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C1426212", "name": "C1426212#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}}
{"token": ["C0076705#ent", "<e1>", "(", "TCZ", ")", "is", "an", "C0003308#ent", "<e2>", "broad", "spectrum", "activity", "."], "h": {"id": "C0076705", "name": "C0076705#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [7, 8]}}
{"token": ["C0076705#ent", "<e1>", "is", "a", "new", "imidazolic", "agent", "an", "intense", "C0003308#ent", "<e2>"], "h": {"id": "C0076705", "name": "C0076705#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [9, 10]}}
{"token": ["C0076705#ent", "<e1>", "is", "a", "new", "C0003308#ent", "<e2>", "broad-spectrum", "activity", "."], "h": {"id": "C0076705", "name": "C0076705#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [5, 6]}}
{"token": ["Two", "clinical", "trials", "performed", "to", "determine", "the", "relative", "efficacy", "of", "C0076705#ent", "<e1>", ",", "a", "new", "C0003308#ent", "<e2>", "treating", "patients", "with", "tinea", "pedis"], "h": {"id": "C0076705", "name": "C0076705#ent", "pos": [10, 11]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [15, 16]}}
{"token": ["C4078840#ent", "<e1>", "CPR", "or", "C1335232#ent", "<e2>", ")", "is", "the", "obligatory", "electron", "donor", "for", "all", "microsomal", "cytochrome", "P450", "CYP", "or", "P450)-catalyzed", "monooxygenase", "reactions", "."], "h": {"id": "C4078840", "name": "C4078840#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335232", "name": "C1335232#ent", "pos": [4, 5]}}
{"token": ["Because", "a", "low", "beta-secretase", "activity", "previously", "reported", "in", "rodent", "astrocytes", ",", "we", "wondered", "whether", "modifications", "of", "the", "APP", "amino", "acid", "sequence", "the", "C3811065#ent", "<e1>", "modify", "the", "astrocytic", "production", "of", "C1705543#ent", "<e2>", "."], "h": {"id": "C3811065", "name": "C3811065#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [29, 30]}}
{"token": ["In", "conclusion", ",", "we", "report", "the", "novel", "observation", "that", "the", "C0216471#ent", "<e1>", "ERK", ")", "pathway", "specifically", "represses", "IGFBP-5", "expression", "in", "C1425042#ent", "<e2>", "."], "h": {"id": "C0216471", "name": "C0216471#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1425042", "name": "C1425042#ent", "pos": [20, 21]}}
{"token": ["A", "multicenter", ",", "prospective", "study", "conducted", "in", "five", "European", "countries", "observe", "outcome", "in", "C0001975#ent", "<e1>", "treated", "for", "24", "weeks", "with", "C0284941#ent", "<e2>", "and", "various", "psychosocial", "support", "techniques", "within", "the", "setting", "of", "standard", "patient", "care"], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0284941", "name": "C0284941#ent", "pos": [20, 21]}}
{"token": ["Because", "these", "systems", "are", "implicated", "in", "excess", "calcium", "entry", "to", "C0001975#ent", "<e1>", "withdrawal-induced", "neurotoxicity", ",", "we", "evaluated", "the", "effects", "of", "C0284941#ent", "<e2>", "on", "these", "parameters", "in", "neuronal", "cultures", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0284941", "name": "C0284941#ent", "pos": [20, 21]}}
{"token": ["Acute", "treatment", "PMA", "also", "stimulated", "C0388638#ent", "<e1>", "through", "a", "C0033640#ent", "<e2>", "process", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "plasma", "levels", "of", "several", "C1540291#ent", "<e1>", "the", "exercise-induced", "changes", "on", "these", "plasma", "levels", "C0019099#ent", "<e2>", "patients", "."], "h": {"id": "C1540291", "name": "C1540291#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [22, 23]}}
{"token": ["In", "the", "continuous", "presence", "of", "10(-6", ")", "mol/L", "enalaprilat", ",", "doxazosin", "with", "a", "C1839576#ent", "<e1>", "value", "of", "9.10", "was", "a", "2.4-fold", "more", "potent", "C0001640#ent", "<e2>", "in", "the", "absence", "of", "enalaprilat", "."], "h": {"id": "C1839576", "name": "C1839576#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [23, 24]}}
{"token": ["The", "C1839576#ent", "<e1>", "values", "of", "chlorpromazine", "on", "the", "C0001640#ent", "<e2>", ",", "muscarinic", "and", "histaminic", "(", "H1", ")", "receptors", "are", "8.96", ",", "7.17", ",", "and", "7.90", ",", "respectively", "."], "h": {"id": "C1839576", "name": "C1839576#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [8, 9]}}
{"token": ["C0152026#ent", "<e1>", "the", "hallmark", "of", "eye", "disease", "and", "much", "of", "the", "C0348165#ent", "<e2>", "linked", "to", "small", "artery", "occlusions"], "h": {"id": "C0152026", "name": "C0152026#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0348165", "name": "C0348165#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "diazoxide", "activates", "NF", "kappa", "B", "C3539645#ent", "<e1>", "signaling", "pathway", "that", "leads", "to", "C0669372#ent", "<e2>", "up-regulation", "after", "24", "hours", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}}
{"token": ["[3H]Phorbol-12,13-dibutyrate-binding", "studies", "that", "membrane", "association", "of", "C3539645#ent", "<e1>", "is", "markedly", "increased", "in", "C0669372#ent", "<e2>", "after", "exposure", "to", "+", "or", "t-butyl", "hydroperoxide"], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}}
{"token": ["We", "demonstrate", "that", "both", "DNA-PK", "and", "C0004135#ent", "<e1>", "efficiently", "phosphorylate", "C1431123#ent", "<e2>", "at", "Thr-366", "in", "vitro", "provide", "evidence", "that", "C0004135#ent", "<e1>", "mediates", "this", "phosphorylation", "in", "vivo"], "h": {"id": "C1431123", "name": "C1431123#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [6, 7]}}
{"token": ["A", "genetically", "confirmed", "case", "of", "C0024408#ent", "<e1>", "SCA", "3", ")", ",", "presenting", "with", "disabling", "foot", "dystonia", "C0031117#ent", "<e2>", "and", "minimal", "cerebellar", "signs", "reported", "."], "h": {"id": "C0024408", "name": "C0024408#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "a", "more", "complex", "abnormality", "in", "the", "IgA", "immune", "response", "necessary", "for", "C0022658#ent", "<e1>", "become", "manifest", "in", "patients", "who", "have", "C0007570#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [23, 24]}}
{"token": ["C0285558#ent", "<e1>", "(", "c-AKT", ",", "PKBalpha", ")", "is", "the", "cellular", "homolog", "the", "C1335947#ent", "<e2>", "v-akt", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335947", "name": "C1335947#ent", "pos": [12, 13]}}
{"token": ["The", "activity", "in", "Cos7", "cells", "expressing", "human", "C0015880#ent", "<e1>", "in", "cytoplasm", "decreased", "with", "C3253705#ent", "<e2>", ",", "but", "to", "a", "lesser", "extent", "."], "h": {"id": "C0015880", "name": "C0015880#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3253705", "name": "C3253705#ent", "pos": [13, 14]}}
{"token": ["Class", "I", "agents", "the", "standard", "membrane-stabilizing", "drugs", "such", "as", "lidocaine", ",", "quinidine", ",", "and", "procainamide", ";", "newer", "class", "I", "agents", "include", "disopyramide", ",", "C0003639#ent", "<e1>", ",", "tocainide", ",", "and", "C0086303#ent", "<e2>", "."], "h": {"id": "C0003639", "name": "C0003639#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0086303", "name": "C0086303#ent", "pos": [29, 30]}}
{"token": ["We", "synthesized", "twenty", "C0030956#ent", "<e1>", "related", "to", "C0287225#ent", "<e2>", "and", "FGRPs", "containing", "either", "an", "L-", "or", "a", "D-amino", "acid", "position", "2", "used", "them", "to", "identify", "FGRPs", "in", "atrial", "extracts", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0287225", "name": "C0287225#ent", "pos": [7, 8]}}
{"token": ["C1413044#ent", "<e1>", "CA", "III", "EC", "4.2.1.1", "is", "a", "C4283758#ent", "<e2>", "exhibits", "a", "relatively", "low", "carbon", "dioxide", "hydratase", "activity", "."], "h": {"id": "C1413044", "name": "C1413044#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4283758", "name": "C4283758#ent", "pos": [8, 9]}}
{"token": ["The", "result", "indicates", "the", "predominant", "expression", "of", "this", "C0079429#ent", "<e1>", "in", "Purkinje", "cells", "the", "cerebellar", "cortex", "where", "C1412344#ent", "<e2>", "mRNA", "was", "rather", "repressed", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412344", "name": "C1412344#ent", "pos": [17, 18]}}
{"token": ["Semi-quantitative", "reverse", "transcription-polymerase", "chain", "reaction", "RT-PCR", ")", "showed", "the", "decreased", "expression", "of", "C1419987#ent", "<e1>", "bcl-2", ",", "c-myc", "and", "human", "C1720833#ent", "<e2>", "hTERT", ")", "."], "h": {"id": "C1419987", "name": "C1419987#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1720833", "name": "C1720833#ent", "pos": [19, 20]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "develop", "and", "evaluate", "a", "pulsatile", "multiparticulate", "drug", "delivery", "system", "C0796074#ent", "<e1>", ")", ",", "coated", "with", "aqueous", "dispersion", "Aquacoat", "C1825023#ent", "<e2>", "."], "h": {"id": "C0796074", "name": "C0796074#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1825023", "name": "C1825023#ent", "pos": [25, 26]}}
{"token": ["We", "used", "mice", "with", "disruption", "of", "the", "C1705616#ent", "<e1>", "and", "WIP", "C1417679#ent", "<e2>", "to", "examine", "the", "role", "of", "C1705616#ent", "<e1>", "and", "WIP", "in", "T", "cell", "."], "h": {"id": "C1705616", "name": "C1705616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["Specificity", "assays", "that", "the", "transporter", "involved", "in", "C0876231#ent", "<e1>", "incorporation", "is", "a", "BETA", "transporter", "probably", "C3889419#ent", "<e2>", "."], "h": {"id": "C0876231", "name": "C0876231#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889419", "name": "C3889419#ent", "pos": [15, 16]}}
{"token": ["Analysis", "of", "the", "adult", "hippocampal", "formation", "has", "revealed", "C1421171#ent", "<e1>", "immunoreactivity", "in", "hippocampal", "areas", "CA1", "to", "C1413044#ent", "<e2>", "and", "in", "the", "dentate", "gyrus"], "h": {"id": "C1421171", "name": "C1421171#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413044", "name": "C1413044#ent", "pos": [16, 17]}}
{"token": ["Other", "anti-inflammatory", "drugs", "including", "methotrexate", ",", "C0010592#ent", "<e1>", "and", "the", "newer", "C0595726#ent", "<e2>", "are", "not", "yet", "in", "general", "use", "and", "may", "provide", "new", "pharmacological", "approaches", "the", "treatment", "of", "asthma", "in", "the", "near", "future", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0595726", "name": "C0595726#ent", "pos": [11, 12]}}
{"token": ["This", "paper", "will", "review", "the", "studies", "using", "misoprostol", ",", "C0010592#ent", "<e1>", ",", "tacrolimus", ",", "phosphodiesterase", "inhibitors", "capsaicin", ",", "C0595726#ent", "<e2>", "serotonin-reuptake", "inhibitors", "treatment", "of", "dogs", "with", "atopic", "dermatitis"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0595726", "name": "C0595726#ent", "pos": [18, 19]}}
{"token": ["An", "increase", "in", "feeding", "response", "C1822955#ent", "<e1>", "was", "also", "obtained", "after", "14", "days", "of", "C0054876#ent", "<e2>", "administration", ",", "confirming", "the", "amphetamine-like", "properties", "of", "this", "drug", "."], "h": {"id": "C1822955", "name": "C1822955#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0054876", "name": "C0054876#ent", "pos": [14, 15]}}
{"token": ["A", "recombinant", "virus", "a", "hybrid", "and", "polh", "promoter", "(", "Pcappolh", ")", "was", "also", "constructed", "and", "studied", ";", "Pcappolh", "contained", "the", "two", "C1710292#ent", "<e1>", "Pcap", "and", "a", "proximal", "tsp", "of", "C1418733#ent", "<e2>", "."], "h": {"id": "C1710292", "name": "C1710292#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1418733", "name": "C1418733#ent", "pos": [29, 30]}}
{"token": ["Since", "the", "identification", "of", "a", "chimeric", "C1527416#ent", "<e1>", "induces", "mendelian", "hypertension", "polymorphisms", "in", "C1527416#ent", "<e1>", "C1413857#ent", "<e1>", ")", "has", "been", "one", "of", "major", "targets", "for", "molecular", "analyses", "association", "with", "hypertension", "."], "h": {"id": "C1527416", "name": "C1527416#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413857", "name": "C1413857#ent", "pos": [15, 16]}}
{"token": ["To", "address", "the", "impact", "of", "the", "locked", "conformation", "ligand", "binding", "we", "compared", "extracellular", "domains", "wild-type", "C0812265#ent", "<e1>", ",", "mutant", "domains", "in", "a", "C0907533#ent", "<e2>", "locked", "or", "extended", "conformation", "and", "partial", "extracellular", "domain", "constructs", "."], "h": {"id": "C0812265", "name": "C0812265#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [22, 23]}}
{"token": ["One", "neuron-specific", "protein", "Purkinje", "cell", "protein", "4", "C1418387#ent", "<e1>", ")", ",", "was", "strongly", "expressed", "in", "Y", "cells", "the", "ferret", "C1428865#ent", "<e2>", "and", "in", "the", "magnocellular", "layers", "of", "the", "primate", "C1428865#ent", "<e2>", "."], "h": {"id": "C1418387", "name": "C1418387#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1428865", "name": "C1428865#ent", "pos": [19, 20]}}
{"token": ["Hemodynamic", "effects", "of", "C0064079#ent", "<e1>", "(", "IS-5-MN", ")", "were", "studied", "in", "20", "patients", "with", "C0010068#ent", "<e2>"], "h": {"id": "C0064079", "name": "C0064079#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [14, 15]}}
{"token": ["Hemodynamic", "effects", "of", "isosorbide-5-mononitrate", "(", "C0064079#ent", "<e1>", ")", "were", "studied", "in", "20", "patients", "with", "C0010068#ent", "<e2>"], "h": {"id": "C0064079", "name": "C0064079#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [14, 15]}}
{"token": ["The", "haemodynamic", "effect", "of", "C0064079#ent", "<e1>", "(", "ISMN", ")", "was", "studied", "in", "20", "patients", "with", "C0010068#ent", "<e2>"], "h": {"id": "C0064079", "name": "C0064079#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [15, 16]}}
{"token": ["This", "investigation", "was", "undertaken", "to", "examine", "the", "effects", "of", "C0032896#ent", "<e1>", ",", "a", "relatively", "C0304516#ent", "<e2>", "on", "regional", "myocardial", "dimensions", "and", "shortening", "during", "acute", "coronary", "arterial", "occlusion", "dogs", "."], "h": {"id": "C0032896", "name": "C0032896#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [14, 15]}}
{"token": ["Recognition", "of", "the", "\"", "occulomucocutaneous", "syndrome", "related", "to", "C0032896#ent", "<e1>", "administration", "has", "caused", "the", "safety", "of", "other", "C0304516#ent", "<e2>", "come", "under", "close", "scrutiny", "."], "h": {"id": "C0032896", "name": "C0032896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [17, 18]}}
{"token": ["As", "C3814453#ent", "<e1>", "is", "frequently", "co-amplified", "with", "C1426902#ent", "<e2>", ",", "we", "co-transfected", "the", "two", "genes", "into", "both", "wild-type", "and", "partial", "revertants", "."], "h": {"id": "C3814453", "name": "C3814453#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1426902", "name": "C1426902#ent", "pos": [7, 8]}}
{"token": ["Three", "patients", "presented", "with", "C3891815#ent", "<e1>", "the", "fourth", "with", "fever", ",", "skin", "lesions", "and", "C0231218#ent", "<e2>", "."], "h": {"id": "C3891815", "name": "C3891815#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [14, 15]}}
{"token": ["Clinical", "experience", "cisapride", "is", "lacking", "but", "avoidance", "with", "all", "protease", "inhibitors", "recommended", ",", "although", "C0286738#ent", "<e1>", "is", "thought", "to", "have", "clinically", "insignificant", "effects", "on", "C1142644#ent", "<e2>", "."], "h": {"id": "C0286738", "name": "C0286738#ent", "pos": [14, 15]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [24, 25]}}
{"token": ["C2985240#ent", "<e1>", "down-regulates", "the", "expression", "of", "the", "glutamate", "transporter", "C2985245#ent", "<e2>", ";", "thus", ",", "it", "is", "implicated", "in", "glutamate-induced", "excitotoxic", "damage", "to", "neurons", "as", "evident", "in", "HIV-associated", "neurodegeneration", "."], "h": {"id": "C2985240", "name": "C2985240#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2985245", "name": "C2985245#ent", "pos": [9, 10]}}
{"token": ["In", "patients", "with", "C2713546#ent", "<e1>", "of", "17", "alpha-", "and", "C0038304#ent", "<e2>", ",", "the", "entire", "MCH", "pathway", "may", "be", "initially", "stimulated", "by", "ACTH", "alone", "in", "the", "presence", "of", "reduced", "cortisol", "production"], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038304", "name": "C0038304#ent", "pos": [9, 10]}}
{"token": ["Overall", ",", "few", "hyperandrogenic", "patients", "actually", "have", "isolated", "C2713546#ent", "<e1>", "of", "3", "beta-hydroxysteroid", "dehydrogenase", "21-hydroxylase", ",", "and", "C0038304#ent", "<e2>", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038304", "name": "C0038304#ent", "pos": [17, 18]}}
{"token": ["One", "child", "had", "a", "human", "chorionic", "gonadotropin", "suggestive", "of", "17", "-", "20", "desmolase", "deficiency", "and", "on", "further", "evaluation", "he", "also", "had", "partial", "C2713546#ent", "<e1>", "of", "the", "C0038304#ent", "<e2>", "17", "alpha-hydroxylase", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038304", "name": "C0038304#ent", "pos": [26, 27]}}
{"token": ["More", "than", "90", "%", "of", "cases", "of", "congenital", "adrenal", "hyperplasia", "CAH", ")", "are", "caused", "by", "mutations", "of", "the", "CYP21", "gene", "result", "in", "C2713546#ent", "<e1>", "of", "the", "C0038304#ent", "<e2>"], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038304", "name": "C0038304#ent", "pos": [26, 27]}}
{"token": ["In", "the", "others", ",", "which", "all", "presented", "C0234533#ent", "<e1>", "diving", "produced", "a", "reduction", "in", "seizure", "C0720099#ent", "<e2>", ",", "especially", "during", "the", "generalisation", "phase", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [15, 16]}}
{"token": ["The", "number", "of", "C0242966#ent", "<e1>", "criteria", "and", "the", "C1420151#ent", "<e2>", "scores", "in", "the", "nonsurvivors", "showed", "higher", "values", "than", "those", "in", "the", "survivors", "."], "h": {"id": "C0242966", "name": "C0242966#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420151", "name": "C1420151#ent", "pos": [8, 9]}}
{"token": ["Forty-eight", "patients", "with", "C0242966#ent", "<e1>", "or", "sepsis", "were", "classified", "as", "20", "C1420151#ent", "<e2>", "and", "28", "non-DIC", "patients", "."], "h": {"id": "C0242966", "name": "C0242966#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420151", "name": "C1420151#ent", "pos": [11, 12]}}
{"token": ["The", "clinical", "significance", "evaluating", "autonomic", "nervous", "system", "in", "the", "early", "stages", "C0028968#ent", "<e1>", "C0752120#ent", "<e2>", ")", "has", "been", "investigated", "in", "13", "C0752120#ent", "<e2>", "out-patients", "(", "7", "males", "and", "6", "females", ",", "mean", "age", "51.0", "years", ")", "."], "h": {"id": "C0028968", "name": "C0028968#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C0752120", "name": "C0752120#ent", "pos": [13, 14]}}
{"token": ["Psychological", "impairment", "more", "often", "observed", "among", "patients", "with", "a", "combination", "of", "C0029002#ent", "<e1>", ",", "C0014547#ent", "<e2>", "and/or", "growth", "retardation", "the", "patients", "with", "C0029002#ent", "<e1>", ",", "C0014547#ent", "<e2>", "or", "growth", "retardation", "."], "h": {"id": "C0029002", "name": "C0029002#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [14, 15]}}
{"token": ["A", "C1334043#ent", "<e1>", "of", "the", "fission", "yeast", "protein", "kinase", "(", "C1413181#ent", "<e2>", ")", "is", "a", "component", "of", "M", "phase", "factor", "in", "Xenopus", "oocytes"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413181", "name": "C1413181#ent", "pos": [10, 11]}}
{"token": ["C1334043#ent", "<e1>", "to", "p34", "and", "C1413181#ent", "<e2>", "have", "been", "found", "only", "in", "other", "trypanosomatids", ",", "suggesting", "that", "these", "proteins", "are", "unique", "to", "this", "ancient", "family", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413181", "name": "C1413181#ent", "pos": [5, 6]}}
{"token": ["Analgesics", ",", "C0003419#ent", "<e1>", "and", "psychotropic", "drugs", "the", "C0035064#ent", "<e2>", "most", "commonly", "used", "by", "both", "sexes", "and", "accounted", "for", "three-quarters", "of", "all", "admissions", "."], "h": {"id": "C0003419", "name": "C0003419#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [8, 9]}}
{"token": ["In", "the", "final", "model", ",", "HEP", ",", "C1417239#ent", "<e1>", ",", "and", "BSA", "are", "the", "main", "predictors", "of", "C0246415#ent", "<e2>", "CL", "."], "h": {"id": "C1417239", "name": "C1417239#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0246415", "name": "C0246415#ent", "pos": [17, 18]}}
{"token": ["Prior", "intraperitoneal", "administration", "both", "C3537004#ent", "<e1>", "(", "atropine", ")", "as", "well", "as", "alpha-blocking", "medication", "(", "C0242430#ent", "<e2>", ")", "produced", "a", "very", "significant", "decrease", "in", "stress", "ulcers"], "h": {"id": "C3537004", "name": "C3537004#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242430", "name": "C0242430#ent", "pos": [15, 16]}}
{"token": ["The", "increase", "in", "cerebral", "blood", "flow", "the", "result", "of", "a", "direct", "C3537240#ent", "<e1>", "effect", "of", "C0060464#ent", "<e2>", "and", "is", "not", "secondary", "to", "an", "increase", "in", "cerebral", "metabolism"], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0060464", "name": "C0060464#ent", "pos": [15, 16]}}
{"token": ["The", "orphan", "receptor", "C1538915#ent", "<e1>", "was", "widely", "used", "for", "fusion", "by", "C0017343#ent", "<e2>", "both", "blood", "and", "lung", "viruses", "but", "none", "used", "the", "cytomegalovirus-encoded", "receptor", "US28", "."], "h": {"id": "C1538915", "name": "C1538915#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017343", "name": "C0017343#ent", "pos": [11, 12]}}
{"token": ["Over", "the", "12-h", "period", "blood", "glucose", "pyruvate", "and", "C0017868#ent", "<e1>", "were", "significantly", "lower", ",", "and", "plasma", "insulin", "C0795692#ent", "<e2>", "alanine", "and", "plasma", "non-esterified", "fatty", "acids", "NEFA", ")", "significantly", "higher", "in", "insulinoma", "patients", "."], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0795692", "name": "C0795692#ent", "pos": [17, 18]}}
{"token": ["It", "reduces", "arterial", "pressure", "reverses", "bi-atrial", "and", "right", "ventricular", "hypertrophy", "reduces", "the", "changes", "in", "the", "C0949646#ent", "<e1>", "isoenzyme", "patterns", ",", "and", "normalizes", "subendocardial", "fibrosis", "the", "level", "of", "C1417807#ent", "<e2>", "."], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [27, 28]}}
{"token": ["An", "enzyme-linked", "immunosorbent", "assay", "ELISA", ")", "method", "was", "used", "to", "quantitate", "the", "amount", "of", "actin", "and", "C0949646#ent", "<e1>", "in", "corneal", "epithelium", "mice", "aged", "C1417807#ent", "<e2>", "1", "to", "24", "months", "."], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [23, 24]}}
{"token": ["The", "authors", "performed", "comparative", "analysis", "the", "C0242965#ent", "<e1>", "of", "145", "clinical", "and", "environmental", "isolates", "of", "Vibrio", "cholerae", "C1416870#ent", "<e2>", "using", "single", "locus", "multiplex", "PCR"], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416870", "name": "C1416870#ent", "pos": [17, 18]}}
{"token": ["Unlike", "the", "HFV", "genomic", "organization", "the", "SFV-1", "pol", "gene", "overlaps", "the", "C0017343#ent", "<e1>", "thus", ",", "the", "C1412821#ent", "<e2>", "for", "HFV", "between", "pol", "and", "env", "is", "not", "present", "in", "SFV-1", "."], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [16, 17]}}
{"token": ["The", "C0034414#ent", "<e1>", "binding", "in", "plasma", "of", "patients", "with", "C0020476#ent", "<e2>", "did", "not", "differ", "statistically", "from", "that", "in", "the", "normal", "subjects"], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [9, 10]}}
{"token": ["The", "insulin-producing", "betacells", "found", "to", "express", "AbetaPP", ",", "C3815269#ent", "<e1>", "and", "PS2", "at", "high", "levels", ",", "and", "C2986918#ent", "<e2>", "at", "a", "lower", "level", "."], "h": {"id": "C3815269", "name": "C3815269#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2986918", "name": "C2986918#ent", "pos": [17, 18]}}
{"token": ["A", "previously", "asymptomatic", "30", "year", "old", "man", "presented", "with", "rhabdomyolysis", ",", "C0030552#ent", "<e1>", "and", "acute", "encephalopathy", "strenuous", "exertion", "the", "C0041912#ent", "<e2>", "without", "adequate", "food", "intake"], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [19, 20]}}
{"token": ["Immunosuppression", "was", "directly", "related", "to", "C0039663#ent", "<e1>", "than", "to", "non-specific", "C3714552#ent", "<e2>", "factors", "since", "body", "weights", "stable", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [10, 11]}}
{"token": ["Recent", "studies", "have", "demonstrated", "that", "H(2)O(2", ")", "acts", "as", "a", "second", "messenger", "of", "mitogenic", "signaling", "and", "that", "C0007367#ent", "<e1>", "is", "under", "the", "regulation", "of", "PKA", "and", "C3539645#ent", "<e2>", "signaling", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [26, 27]}}
{"token": ["Mutations", "in", "the", "human", "C1423814#ent", "<e1>", "been", "shown", "to", "occur", "in", "autosomal-recessive", "pantothenate", "kinase-associated", "neurodegeneration", "a", "C0039082#ent", "<e2>", "originally", "described", "by", "Hallervorden", "and", "Spatz", "."], "h": {"id": "C1423814", "name": "C1423814#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [16, 17]}}
{"token": ["Other", "derivatives", "of", "C3541860#ent", "<e1>", ",", "such", "as", "capsazepine", ",", "C0073081#ent", "<e2>", ",", "and", "piperine", "also", "blocked", "potassium", "channels"], "h": {"id": "C3541860", "name": "C3541860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073081", "name": "C0073081#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "C1336938#ent", "<e1>", "mutation", "may", "be", "an", "under", "recognized", "cause", "of", "C0019069#ent", "<e2>", ",", "especially", "in", "cases", "where", "the", "inheritance", "pattern", "not", "consistent", "with", "transmission", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [13, 14]}}
{"token": ["1-desamino-8-D-arginine", "vasopressin", "DDAVP", ")", "increases", "factor", "VIII", "FVIII", ")", "and", "von", "Willebrand", "factor", "C1336938#ent", "<e1>", ")", "levels", "in", "patients", "with", "C0019069#ent", "<e2>", "in", "some", "patients", "with", "von", "Willebrand", "disease"], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [13, 14]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [20, 21]}}
{"token": ["The", "cardioselective", "betablocking", "agent", "C0025859#ent", "<e1>", "was", "used", "to", "treat", "21", "outpatients", "with", "essential", "C0020538#ent", "<e2>", "1", "and", "2", "of", "the", "OMS", "scale", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [14, 15]}}
{"token": ["Weight", "reduction", "compared", "with", "C0025859#ent", "<e1>", "(", "200", "mg", "daily", ")", "in", "a", "randomized", "placebo-controlled", "trial", "first-line", "treatment", "C0020538#ent", "<e2>", "diastolic", "blood", "pressure", "-", "109", "mm", "Hg", ")", "in", "56", "overweight", "patients", "aged", "under", "55", "years", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["C0049574#ent", "<e1>", "also", "potentiated", "the", "stimulation", "of", "N-acetyltransferase", "activity", "by", "another", "beta-adrenergic", "agonist", "C0093017#ent", "<e2>", "."], "h": {"id": "C0049574", "name": "C0049574#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0093017", "name": "C0093017#ent", "pos": [13, 14]}}
{"token": ["Analysis", "of", "C3542429#ent", "<e1>", "and", "LG", "cells", "coexpression", "of", "C1704881#ent", "<e2>", "with", "OX19", "or", "L", "chain", "that", "significant", "percentages", "of", "C1704881#ent", "<e2>", "bearing", "cells", "also", "expressed", "T", "or", "B", "cell", "markers", "."], "h": {"id": "C3542429", "name": "C3542429#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704881", "name": "C1704881#ent", "pos": [9, 10]}}
{"token": ["C1412728#ent", "<e1>", "cleaves", "the", "amyloid", "precursor", "protein", "the", "C3811065#ent", "<e2>", "is", "thought", "to", "contribute", "to", "amyloid", "beta", "protein", "."], "h": {"id": "C1412728", "name": "C1412728#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811065", "name": "C3811065#ent", "pos": [8, 9]}}
{"token": ["The", "combination", "of", "parathion", "and", "estrogen", "induced", "down-regulation", "of", "three", "sulfotransferases", ",", "C1413878#ent", "<e1>", "and", "CYP4F3", ",", "MGST1", ",", "all", "metallothioneins", "and", "TPMT", "C0017337#ent", "<e2>", "."], "h": {"id": "C1413878", "name": "C1413878#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [23, 24]}}
{"token": ["C1418938#ent", "<e1>", "induced", "the", "expression", "of", "C1413882#ent", "<e2>", "mRNA", "but", "not", "cp37", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413882", "name": "C1413882#ent", "pos": [6, 7]}}
{"token": ["Y-27632", "[", "(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl", ")", "cyclohexanecarboxamide", "]", "also", "prevented", "the", "C0912407#ent", "<e1>", "induced", "activation", "of", "C2936824#ent", "<e2>"], "h": {"id": "C0912407", "name": "C0912407#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrate", "in", "this", "report", "that", "MeDTC-SO", "is", "a", "potent", "irreversible", "inhibitor", "of", "recombinant", "rat", "liver", "C2827577#ent", "<e1>", "rlmALDH", ")", ",", "the", "C0027203#ent", "<e2>", "responsible", "for", "oxidizing", "acetaldehyde", "during", "ethanol", "metabolism", "."], "h": {"id": "C2827577", "name": "C2827577#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [22, 23]}}
{"token": ["The", "two", "other", "ORFs", "were", "incomplete", "and", "the", "deduced", "amino", "acid", "sequences", "similarities", "to", "an", "C0002484#ent", "<e1>", "encoded", "in", "the", "streptomycin", "biosynthesis", "C1418864#ent", "<e2>", "S.", "griseus", "and", "to", "the", "transposase", "of", "IS112", ",", "respectively", "."], "h": {"id": "C0002484", "name": "C0002484#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418864", "name": "C1418864#ent", "pos": [22, 23]}}
{"token": ["Combination", "of", "GHRH", "with", "C0033497#ent", "<e1>", "induced", "an", "increase", "of", "C3539616#ent", "<e2>", "that", "was", "significant", "only", "with", "regard", "to", "peak", "(", "28.9", "+", "/-", "8.4", "micrograms/L", ")", "but", "not", "to", "AUC", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [10, 11]}}
{"token": ["pretreatment", "with", "C0033497#ent", "<e1>", "resulted", "in", "an", "increased", "response", "of", "plasma", "C3539616#ent", "<e2>", "level", "to", "the", "exercise", "on", "a", "bicycle", "ergometer"], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [11, 12]}}
{"token": ["Chronic", "treatment", "oxprenolol", "or", "C0033497#ent", "<e1>", "in", "active", "hypertensive", "patients", "was", "associated", "with", "elevation", "of", "serum", "growth", "hormone", "C3539616#ent", "<e2>", ")", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [18, 19]}}
{"token": ["Concomitant", "treatment", "of", "animals", "with", "the", "beta-adrenergic", "antagonist", "C0033497#ent", "<e1>", "completely", "blocked", "the", "noradrenaline-induced", "suppression", "of", "C3539616#ent", "<e2>", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [16, 17]}}
{"token": ["C0009014#ent", "<e1>", "failed", "to", "differentiate", "C1704876#ent", "<e2>", "from", "IPD", "and", "ILOCA", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704876", "name": "C1704876#ent", "pos": [5, 6]}}
{"token": ["Significantly", "fewer", "recipients", "of", "C0939219#ent", "<e1>", "discontinued", "treatment", "because", "of", "adverse", "events", "individuals", "receiving", "chloroquine", "plus", "C0008241#ent", "<e2>", "or", "mefloquine", "(", "p", "<", "0.05", ")", "."], "h": {"id": "C0939219", "name": "C0939219#ent", "pos": [4, 5]}, "relation": "has_constitutional_part", "t": {"id": "C0008241", "name": "C0008241#ent", "pos": [16, 17]}}
{"token": ["Chemoprophylactics", "used", "were", ":", "C0939219#ent", "<e1>", "2", "%", ")", ";", "chloroquine", "and", "C0008241#ent", "<e2>", "15", "(", "30", "%", ")", ";", "doxycycline", "16", "(", "33", "%", ")", ";", "mefloquine", "17", "35", "%", ")", "."], "h": {"id": "C0939219", "name": "C0939219#ent", "pos": [4, 5]}, "relation": "has_constitutional_part", "t": {"id": "C0008241", "name": "C0008241#ent", "pos": [12, 13]}}
{"token": ["A", "C0032594#ent", "<e1>", "by", "gradation", "and", "purification", "contains", "Ara", ",", "C1415495#ent", "<e2>", ",", "Xyl", ",", "GalA.", "Gal", "and", "Glc", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415495", "name": "C1415495#ent", "pos": [10, 11]}}
{"token": ["The", "elimination", "or", "persistence", "of", "C0026945#ent", "<e1>", "monitored", "by", "diamidino-2-phenylindole", "(", "C1415831#ent", "<e2>", ")", "DNA", "staining", "RNA", "hybridization", "test", "broth-agar", "microbiological", "culturing", "."], "h": {"id": "C0026945", "name": "C0026945#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415831", "name": "C1415831#ent", "pos": [11, 12]}}
{"token": ["Calmodulin", "inhibitors", "disruption", "of", "cytoskeletal", "elements", "cytochalasin", "B", "C0009262#ent", "<e1>", "also", "reduced", "C1704947#ent", "<e2>", "recovery", "significantly", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [12, 13]}}
{"token": ["The", "separable", "neurochemicals", "not", "found", "by", "this", "procedure", "in", "the", "Swiss", "male", "mouse", "tissues", "DL-3,4-dihydroxyphenylglycol,5-hydroxytryptophan", ",", "epinephrine", ",", "DL-octopamine", ",", "metanephrine", ",", "C0011498#ent", "<e1>", ",", "homovanillyl", "alcohol", "N-acetylserotonin", ",", "tyramine", "and", "C0030140#ent", "<e2>", "."], "h": {"id": "C0011498", "name": "C0011498#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0030140", "name": "C0030140#ent", "pos": [31, 32]}}
{"token": ["This", "syndrome", "probably", "arose", "as", "a", "consequence", "of", "an", "interaction", "between", "the", "C0026457#ent", "<e1>", "selegiline", ",", "the", "sympathomimetic", "agent", "ephedrine", ",", "and", "a", "C3536819#ent", "<e2>"], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3536819", "name": "C3536819#ent", "pos": [23, 24]}}
{"token": ["The", "C0040822#ent", "<e1>", "disappeared", "24", "-", "72", "hr", "after", "stopping", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C0040822", "name": "C0040822#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [11, 12]}}
{"token": ["Oral", "administration", "C0718066#ent", "<e1>", "increases", "F-cell", "production", "in", "C0002895#ent", "<e2>"], "h": {"id": "C0718066", "name": "C0718066#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "the", "C0030956#ent", "<e1>", "maps", "of", "C3853653#ent", "<e2>", "normal", "and", "malignant", "rat", "cells", "in", "only", "one", "spot", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3853653", "name": "C3853653#ent", "pos": [7, 8]}}
{"token": ["The", "prognosis", "of", "C0023860#ent", "<e1>", "depends", "on", "the", "severity", "of", "C0025309#ent", "<e2>", ",", "due", "to", "the", "elective", "location", "of", "foci", "of", "infection", "in", "the", "brain", "stem", "rhombencephalitis", ")", "."], "h": {"id": "C0023860", "name": "C0023860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025309", "name": "C0025309#ent", "pos": [10, 11]}}
{"token": ["In", "C1421437#ent", "<e1>", "and", "sIBM", "muscle", ",", "C2699749#ent", "<e2>", "migrated", "with", "an", "additional", "band", "on", "immunoblot", "similar", "to", "that", "reported", "in", "FTD-U", "brains", "."], "h": {"id": "C1421437", "name": "C1421437#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2699749", "name": "C2699749#ent", "pos": [7, 8]}}
{"token": ["Since", "C1421437#ent", "<e1>", "brain", "has", "C2699749#ent", "<e2>", "in", "UBIs", ",", "we", "looked", "for", "C2699749#ent", "<e2>", "inclusions", "in", "IBMPFD", "muscle"], "h": {"id": "C1421437", "name": "C1421437#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2699749", "name": "C2699749#ent", "pos": [5, 6]}}
{"token": ["This", "was", "accompanied", "by", "increased", "mRNA", "expression", "of", "leptin", "and", "the", "macrophage", "marker", "C1413234#ent", "<e1>", "in", "white", "adipose", "tissue", "of", "C3538602#ent", "<e2>", "and", "FAS", "in", "liver", "."], "h": {"id": "C1413234", "name": "C1413234#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3538602", "name": "C3538602#ent", "pos": [20, 21]}}
{"token": ["Infection", "of", "the", "central", "nervous", "system", "C0032302#ent", "<e1>", "a", "frequent", "occurrence", "in", "C0026269#ent", "<e2>", "patients", "."], "h": {"id": "C0032302", "name": "C0032302#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [12, 13]}}
{"token": ["However", ",", "in", "vitro", "transcription", "of", "SNR6", "with", "purified", "components", "requires", "neither", "C1705412#ent", "<e1>", "nor", "the", "A", "and", "B", "blocks", "presumably", "because", "C1333718#ent", "<e2>", "recognizes", "the", "upstream", "sequences", "directly", "."], "h": {"id": "C1705412", "name": "C1705412#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333718", "name": "C1333718#ent", "pos": [22, 23]}}
{"token": ["N-terminally", "deleted", "derivatives", "of", "Brf", "have", "been", "examined", "for", "their", "ability", "to", "interact", "with", "C1705412#ent", "<e1>", "with", "the", "other", "components", "of", "C1333718#ent", "<e2>", "and", "for", "participation", "in", "transcription", "."], "h": {"id": "C1705412", "name": "C1705412#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333718", "name": "C1333718#ent", "pos": [21, 22]}}
{"token": ["Because", "the", "assembly", "of", "C1333718#ent", "<e1>", "on", "the", "yeast", "U6", "gene", "in", "vivo", "via", "a", "TFIIIC-dependent", "mechanism", ",", "we", "investigated", "the", "influence", "of", "C1705412#ent", "<e2>", "on", "the", "binding", "polarity", "C1333718#ent", "<e1>", "."], "h": {"id": "C1705412", "name": "C1705412#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1333718", "name": "C1333718#ent", "pos": [4, 5]}}
{"token": ["A", "C1705412#ent", "<e1>", "activity", "which", "complemented", "purified", "C1333718#ent", "<e2>", "and", "RNA", "polymerase", "III", "fractions", "for", "VA", "transcription", "highly", "purified", "from", "cultured", "HeLa", "cells"], "h": {"id": "C1705412", "name": "C1705412#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333718", "name": "C1333718#ent", "pos": [7, 8]}}
{"token": ["Measurements", "of", "GTP", "and", "C0018293#ent", "<e1>", "pr", "showed", "C2987364#ent", "<e2>", "levels", "and", "indicate", "the", "metabolic", "block", "pr", "to", "be", "at", "one", "of", "the", "steps", "converting", "dihydroneopterin", "triphosphate", "sepiapterin", "."], "h": {"id": "C0018293", "name": "C0018293#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}}
{"token": ["Analyses", "of", "a", "variety", "of", "zeste", "mutants", "of", "Drosophila", "melanogaster", "shown", "that", "these", "mutants", "all", "contain", "C0018293#ent", "<e1>", "approximately", "to", "the", "amount", "found", "in", "the", "C2987364#ent", "<e2>", "fly", "."], "h": {"id": "C0018293", "name": "C0018293#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [25, 26]}}
{"token": ["The", "activity", "of", "C0018293#ent", "<e1>", "found", "to", "differ", "between", "C2987364#ent", "<e2>", "and", "yellow-eyed", "mutants", "in", "vivo", "not", "in", "vitro"], "h": {"id": "C0018293", "name": "C0018293#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}}
{"token": ["Mutagenesis", "experiments", "indicate", "that", "stimulation", "of", "I(Ks", ")", "channels", "by", "C1420010#ent", "<e1>", "depends", "on", "residues", "C1418404#ent", "<e2>", ",", "N75", ",", "D76", ",", "and", "P77", "in", "KCNE1", "."], "h": {"id": "C1420010", "name": "C1420010#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418404", "name": "C1418404#ent", "pos": [15, 16]}}
{"token": ["The", "neuritogenic", "as", "well", "as", "synaptogenic", "effects", "C0017082#ent", "<e1>", "may", "be", "interpreted", "by", "their", "action", "on", "C0030940#ent", "<e2>"], "h": {"id": "C0017082", "name": "C0017082#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [16, 17]}}
{"token": ["The", "data", "obtained", "attest", "to", "the", "capability", "of", "C0017082#ent", "<e1>", "of", "influencing", "the", "conformation", "of", "both", "the", "lipid", "and", "C0030940#ent", "<e2>", "biological", "membranes"], "h": {"id": "C0017082", "name": "C0017082#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [19, 20]}}
{"token": ["The", "gene", "for", "complementation", "group", "A", "C1414527#ent", "<e1>", ")", "is", "defective", "in", "the", "majority", "of", "C0015625#ent", "<e2>", "patients", "."], "h": {"id": "C1414527", "name": "C1414527#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [15, 16]}}
{"token": ["The", "similarity", "of", "C0085179#ent", "<e1>", "EMS", ")", "and", "toxic-oil", "syndrome", "(", "TOS", ")", "to", "C0036421#ent", "<e2>", "diffuse", "fasciitis", "eosinophilia", "(", "DFE", ")", "highlights", "the", "potential", "for", "environmental", "agents", "induce", "autoimmune", "disease"], "h": {"id": "C0085179", "name": "C0085179#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [14, 15]}}
{"token": ["Ethanol", "intake", "(", "grams/kg/day", ")", "by", "C2987364#ent", "<e1>", "decreased", "significantly", "after", "diazepam", "or", "zolpidem", "but", "increased", "after", "C0538036#ent", "<e2>", "administration", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0538036", "name": "C0538036#ent", "pos": [17, 18]}}
{"token": ["These", "trials", "involved", "C1424250#ent", "<e1>", "compared", "with", "placebo", ",", "other", "C0003364#ent", "<e2>", "and", "direct", "comparisons", "between", "C1424250#ent", "<e1>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [3, 4]}}
{"token": ["Thus", ",", "CV-11974", "may", "act", "not", "only", "as", "an", "C0003364#ent", "<e1>", "but", "also", "as", "an", "inhibitor", "of", "vascular", "injury", "stimulated", "by", "C1424250#ent", "<e2>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [21, 22]}}
{"token": ["In", "patients", "with", "glomerulonephritis", ",", "the", "serum", "levels", "AM", "are", "elevated", "as", "well", "as", "C0003364#ent", "<e1>", "norepinephrine", "(", "NE", ")", "and", "angiotensin", "II", "C1424250#ent", "<e2>", ")", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [23, 24]}}
{"token": ["A", "member", "of", "the", "Theta", "class", "human", "glutathione", "transferases", "GST", "T1", "-", "1", ")", "was", "found", "to", "display", "the", "greatest", "catalytic", "activity", "the", "C0007257#ent", "<e1>", "BCNU", ")", "of", "the", "C1865138#ent", "<e2>", "studied", "."], "h": {"id": "C0007257", "name": "C0007257#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [29, 30]}}
{"token": ["C1947941#ent", "<e1>", "protection", "and", "crosslinking", "experiments", "suggest", "that", "C1826467#ent", "<e2>", "is", "a", "transmembrane", "protein", "trypsin", "cleavage", "NH2-crosslinking", "sites", "on", "the", "lumenal", "face", "of", "the", "vesicles", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826467", "name": "C1826467#ent", "pos": [8, 9]}}
{"token": ["Bound", "[3H]PAF", "was", "displaceable", "by", "lyso-PAF", ",", "U66985", ",", "CV3988", ",", "but", "not", "U66982", ",", "L652,731", ",", "C1420401#ent", "<e1>", "63,441", "or", "the", "inactive", "C0235480#ent", "<e2>", "isomer", ",", "oleoyl", "C0235480#ent", "<e2>", "."], "h": {"id": "C1420401", "name": "C1420401#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [23, 24]}}
{"token": ["C1517683#ent", "<e1>", ",", "a", "better", "substrate", "for", "C0023689#ent", "<e2>", "methionine", ",", "is", "also", "slightly", "more", "effective", "at", "repression", "than", "methionine", "."], "h": {"id": "C1517683", "name": "C1517683#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023689", "name": "C0023689#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "inhibition", "of", "C1413105#ent", "<e1>", "using", "its", "selective", "inhibitor", ",", "C1138483#ent", "<e2>", ",", "abolished", "ALA-stimulated", "AMPK", "activation", ",", "with", "an", "accompanied", "reduction", "of", "ACC", "phosphorylation", "at", "Ser(79", ")", "."], "h": {"id": "C1413105", "name": "C1413105#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1138483", "name": "C1138483#ent", "pos": [11, 12]}}
{"token": ["The", "C0024518#ent", "<e1>", "been", "shown", "to", "contain", "a", "susceptibility", "locus", "multiple", "sclerosis", "C0026769#ent", "<e2>", ")", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "the", "implications", "of", "aberrant", "C0024518#ent", "<e1>", "expression", "in", "oligodendrocytes", "for", "demyelinating", "diseases", "as", "C0026769#ent", "<e2>", "discussed", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [15, 16]}}
{"token": ["C1335280#ent", "<e1>", "is", "shown", "to", "associate", "with", "and", "dephosphorylate", "Gab1", ",", "suggesting", "that", "EGF-stimulated", "C1705791#ent", "<e2>", "might", "act", "through", "the", "regulation", "of", "C1335280#ent", "<e1>", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335280", "name": "C1335280#ent", "pos": [0, 1]}}
{"token": ["Symptoms", "related", "to", "the", "primary", "tumor", "trismus", ",", "pain", ",", "otitis", "media", "C0232608#ent", "<e1>", "to", "paresis", "of", "the", "soft", "palate", "hearing", "loss", "C0151311#ent", "<e2>"], "h": {"id": "C0232608", "name": "C0232608#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0151311", "name": "C0151311#ent", "pos": [22, 23]}}
{"token": ["We", "incubated", "new", "SeeQuence", "disposable", "contact", "lenses", "in", "ciprofloxacin", ",", "C1882444#ent", "<e1>", "and", "prednisolone", "C0000975#ent", "<e2>", "alone", "and", "in", "combination", "."], "h": {"id": "C1882444", "name": "C1882444#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "on", "histone", "monoubiquitination", "methylation", "is", "the", "result", "of", "defective", "Bur1/Bur2-mediated", "phosphorylation", "of", "C3811702#ent", "<e1>", "on", "its", "serine", "residue", "and", "proper", "recruitment", "of", "the", "C1826536#ent", "<e2>", "complex", "to", "chromatin", "."], "h": {"id": "C3811702", "name": "C3811702#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1826536", "name": "C1826536#ent", "pos": [25, 26]}}
{"token": ["Where", "comparison", "could", "be", "made", ",", "C0063517#ent", "<e1>", "gamma-monoamides", "were", "more", "potent", "than", "C1417487#ent", "<e2>", "gamma-monoamides", "."], "h": {"id": "C0063517", "name": "C0063517#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [13, 14]}}
{"token": ["The", "rapid", "achievement", "of", "effective", "concentrations", "permits", "the", "use", "of", "C0284906#ent", "<e1>", "in", "emergency", "situations", "such", "as", "C0038220#ent", "<e2>"], "h": {"id": "C0284906", "name": "C0284906#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [17, 18]}}
{"token": ["Also", ",", "a", "glutathione", "S-transferase-fused", "C0919432#ent", "<e1>", "directly", "binds", "to", "in", "vitro", "synthesized", "C2347318#ent", "<e2>", "or", "HNF-3", ",", "demonstrating", "protein-protein", "interactions", "C0919432#ent", "<e1>", "and", "the", "two", "transcriptional", "factors"], "h": {"id": "C0919432", "name": "C0919432#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2347318", "name": "C2347318#ent", "pos": [13, 14]}}
{"token": ["Repression", "is", "mediated", "by", "C0919432#ent", "<e1>", "through", "interactions", "with", "C2347318#ent", "<e2>", "and", "FOXA1", ",", "two", "key", "transcription", "factors", "are", "positive", "regulators", "of", "SpB", "transcription", "."], "h": {"id": "C0919432", "name": "C0919432#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2347318", "name": "C2347318#ent", "pos": [9, 10]}}
{"token": ["Saccharomyces", "cerevisiae", "two", "C0034678#ent", "<e1>", "genes", ",", "RAS1", "and", "C1705940#ent", "<e2>", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [9, 10]}}
{"token": ["Homologs", "of", "the", "mammalian", "C0034678#ent", "<e1>", "exist", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "RAS1", "and", "C1705940#ent", "<e2>", ")", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [14, 15]}}
{"token": ["There", "were", "no", "significant", "differences", "in", "baseline", "rating", "scores", "OCD", "or", "C0086132#ent", "<e1>", "those", "who", "entered", "the", "C0040805#ent", "<e2>", "N", "=", "13", ")", "versus", "those", "who", "entered", "the", "placebo", "phase", "N", "=", "8)", "."], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040805", "name": "C0040805#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "the", "expression", "of", "C2346610#ent", "<e1>", "is", "linked", "to", "the", "expression", "of", "C1364020#ent", "<e2>", "blocking", "the", "expression", "of", "C2346610#ent", "<e1>", "leads", "to", "the", "abolishment", "of", "C1364020#ent", "<e2>", "expression", "."], "h": {"id": "C1364020", "name": "C1364020#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2346610", "name": "C2346610#ent", "pos": [6, 7]}}
{"token": ["C0537894#ent", "<e1>", "is", "an", "C1268551#ent", "<e2>", "antifungal", "agent", "broad-spectrum", "activity", "against", "Candida", "and", "Aspergillus", "spp"], "h": {"id": "C0537894", "name": "C0537894#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C1268551", "name": "C1268551#ent", "pos": [4, 5]}}
{"token": ["C0537894#ent", "<e1>", ",", "micafungin", "and", "anidulafungin", "are", "three", "drugs", "of", "the", "C1268551#ent", "<e2>", "antifungals", "available", "for", "intravenous", "treatment", "invasive", "candidiasis", "aspergillosis", "."], "h": {"id": "C0537894", "name": "C0537894#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C1268551", "name": "C1268551#ent", "pos": [11, 12]}}
{"token": ["C1426393#ent", "<e1>", "is", "identical", "to", "C1707839#ent", "<e2>", ",", "which", "encodes", "the", "RNA", "triphosphatase", "of", "the", "yeast", "capping", "apparatus", "."], "h": {"id": "C1426393", "name": "C1426393#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1707839", "name": "C1707839#ent", "pos": [5, 6]}}
{"token": ["The", "amount", "of", "WSN", ",", "WSN", "C0031165#ent", "<e1>", ",", "PTA-soluble", "N", "and", "C0815040#ent", "<e2>", "increased", "during", "processing", ",", "while", "the", "SSN", "and", "PTA-insoluble", "N", "decreased", "."], "h": {"id": "C0031165", "name": "C0031165#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [12, 13]}}
{"token": ["For", "each", "of", "the", "C1875400#ent", "<e1>", "tested", ",", "polyacrylamide", "gel", "electrophoresis", "the", "presence", "of", "C3273614#ent", "<e2>", "revealed", "a", "similar", "polypeptide", "pattern", ",", "under", "reducing", "conditions", ",", "of", "seven", "polypeptides", "with", "apparent", "mol", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273614", "name": "C3273614#ent", "pos": [14, 15]}}
{"token": ["Physicians", "have", "been", "reluctant", "to", "employ", "these", "guidelines", "due", "to", "concerns", "over", "the", "black-box", "warning", "of", "C0013136#ent", "<e1>", "and", "safety", "concerns", "with", "a", "C0038317#ent", "<e2>", "."], "h": {"id": "C0013136", "name": "C0013136#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "when", "mice", "were", "injected", "with", "133", "ng", "of", "C1420498#ent", "<e1>", "or", "3.3", "ng", "of", "Stx2", ",", "survival", "rates", "C4288927#ent", "<e2>", "TNF-alpha-deficient", "mice", "were", "significantly", "higher", "than", "that", "of", "wild-type", "mice", "."], "h": {"id": "C1420498", "name": "C1420498#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4288927", "name": "C4288927#ent", "pos": [20, 21]}}
{"token": ["Mutations", "associated", "with", "rifampicin", "(", "C3890420#ent", "<e1>", ")", "resistance", "in", "two", "regions", "of", "the", "C1412471#ent", "<e2>", "studied", "by", "line", "probe", "INNO-LiPA", "Rif", "."], "h": {"id": "C3890420", "name": "C3890420#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412471", "name": "C1412471#ent", "pos": [14, 15]}}
{"token": ["Denaturing", "gradient", "gel", "electrophoresis", "DGGE", ")", "was", "used", "to", "probe", "for", "mutations", "associated", "with", "rifampin", "(", "C3890420#ent", "<e1>", ")", "resistance", "in", "the", "C1412471#ent", "<e2>", "Mycobacterium", "tuberculosis"], "h": {"id": "C3890420", "name": "C3890420#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412471", "name": "C1412471#ent", "pos": [22, 23]}}
{"token": ["Therefore", ",", "updates", "on", "the", "evolving", "role", "of", "C1622105#ent", "<e1>", "as", "an", "antidote", "for", "acetaminophen", "poisoning", "new", "psychotropic", "medications", "and", "new", "C0003295#ent", "<e2>", "were", "included", "in", "this", "article", "."], "h": {"id": "C1622105", "name": "C1622105#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003295", "name": "C0003295#ent", "pos": [21, 22]}}
{"token": ["The", "zinc", "finger", "transcription", "factors", "GLI1", "and", "C0812306#ent", "<e1>", "are", "considered", "mediators", "of", "the", "C4085201#ent", "<e2>", "signal", "in", "epidermal", "cells", "although", "their", "tumorigenic", "nature", "and", "their", "relative", "contribution", "to", "tumorigenesis", "are", "only", "poorly", "understood", "."], "h": {"id": "C0812306", "name": "C0812306#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4085201", "name": "C4085201#ent", "pos": [14, 15]}}
{"token": ["The", "overlap", "in", "clinical", "presentation", "and", "the", "C0037315#ent", "<e1>", "can", "accompany", "C3665349#ent", "<e2>", ",", "create", "a", "significant", "risk", "of", "misdiagnosis", "of", "sleep", "apnea", "patients", "referred", "to", "sleep", "clinic", "have", "undiagnosed", "C3665349#ent", "<e2>", "."], "h": {"id": "C0037315", "name": "C0037315#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [11, 12]}}
{"token": ["Both", "C1538013#ent", "<e1>", "and", "trnR1", "compete", "with", "trnM2", "for", "the", "same", "C0035681#ent", "<e2>", "common", "transcription", "factors"], "h": {"id": "C1538013", "name": "C1538013#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "a", "patient", "with", "a", "C0494261#ent", "<e1>", "characterized", "by", "profound", "C0009447#ent", "<e2>", "and", "the", "initial", "absence", "of", "T", "lymphocytes", "the", "peripheral", "blood", "PB", ")", "."], "h": {"id": "C0494261", "name": "C0494261#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009447", "name": "C0009447#ent", "pos": [11, 12]}}
{"token": ["Common", "variable", "immunodeficiency", "CVID", ")", "is", "a", "C0494261#ent", "<e1>", "characterized", "by", "C0009447#ent", "<e2>", ",", "recurrent", "bacterial", "infections", "and", "various", "immunologic", "abnormalities"], "h": {"id": "C0494261", "name": "C0494261#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009447", "name": "C0009447#ent", "pos": [11, 12]}}
{"token": ["Cortical", "blindness", "characterized", "by", "C0042798#ent", "<e1>", "the", "presence", "of", "intact", "anterior", "C0155287#ent", "<e2>"], "h": {"id": "C0042798", "name": "C0042798#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155287", "name": "C0155287#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "we", "have", "studied", "the", "effect", "of", "C0383379#ent", "<e1>", "on", "fracture", "healing", "process", "in", "which", "C1522505#ent", "<e2>", "has", "been", "reported", "to", "play", "an", "important", "role", "."], "h": {"id": "C0383379", "name": "C0383379#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1522505", "name": "C1522505#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "newly", "synthesized", "pyrimidine", "compound", "2-piperadino-6-methyl-5-oxo-5,6-dihydro", "(", "7H", ")", "pyrrolo", "[", "3,4-d", "]", "pyrimidine", "maleate", "C0383379#ent", "<e1>", ")", "has", "been", "reported", "to", "augment", "the", "biological", "effect", "C1522505#ent", "<e2>", "in", "vitro"], "h": {"id": "C0383379", "name": "C0383379#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1522505", "name": "C1522505#ent", "pos": [27, 28]}}
{"token": ["Leptin", "is", "the", "crucial", "adipostatic", "hormone", "that", "controls", "food", "intake", "body", "weight", "the", "activation", "of", "specific", "C1366515#ent", "<e1>", "OB-R", ")", "in", "the", "hypothalamic", "arcuate", "nucleus", "C0001857#ent", "<e2>", ")", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001857", "name": "C0001857#ent", "pos": [25, 26]}}
{"token": ["A", "previously", "reported", "pharmacokinetic", "interaction", "between", "C0054138#ent", "<e1>", "and", "carbamazepine", ",", "an", "inducer", "of", "cytochrome", "P450", "CYP", ")", "C1142644#ent", "<e2>", ",", "suggests", "possible", "involvement", "of", "CYP3A4", "in", "the", "metabolism", "of", "C0054138#ent", "<e1>", "."], "h": {"id": "C0054138", "name": "C0054138#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [18, 19]}}
{"token": ["The", "C0039082#ent", "<e1>", "is", "associated", "with", "or", "all", "the", "features", "of", "C0742395#ent", "<e2>", "cardiac", "disease", "skeletal", "abnormalities", "ocular", "defects", "and", "a", "distinctive", "facial", "appearance", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0742395", "name": "C0742395#ent", "pos": [11, 12]}}
{"token": ["The", "C1334693#ent", "<e1>", "was", "found", "to", "interact", "with", "C1413599#ent", "<e2>", ",", "but", "not", "with", "MreB", ",", "revealing", "a", "clear", "distinction", "between", "the", "function", "of", "the", "two", "paralogues", "."], "h": {"id": "C1334693", "name": "C1334693#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413599", "name": "C1413599#ent", "pos": [8, 9]}}
{"token": ["We", "describe", "a", "patient", "with", "elevated", "pulmonary", "arterial", "pressures", "associated", "with", "C0040021#ent", "<e1>", "who", "had", "no", "other", "discernible", "causes", "of", "C0155616#ent", "<e2>"], "h": {"id": "C0040021", "name": "C0040021#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0155616", "name": "C0155616#ent", "pos": [20, 21]}}
{"token": ["Large", "C0056562#ent", "<e1>", ",", "which", "were", "found", "in", "C3179066#ent", "<e2>", "of", "Pssu-ipt", ",", "occupied", "up", "to", "16", "%", "of", "chloroplast", "volume"], "h": {"id": "C0056562", "name": "C0056562#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [8, 9]}}
{"token": ["The", "enzyme", ",", "containing", "two", "conserved", "C0085249#ent", "<e1>", "showed", "59", "and", "61", "%", "identity", "at", "the", "C2917660#ent", "<e2>", "to", "class", "2", "hyaluronan", "synthase", "chondroitin", "synthase", "Pasteurella", "multocida", "respectively", "."], "h": {"id": "C0085249", "name": "C0085249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [16, 17]}}
{"token": ["The", "influence", "of", "fatty", "acids", "the", "binding", "of", "C0022635#ent", "<e1>", "(", "KP", ")", ",", "an", "C3536840#ent", "<e2>", ",", "to", "HSA", "was", "examined", "by", "using", "a", "photoaffinity", "labeling", "technique"], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536840", "name": "C3536840#ent", "pos": [15, 16]}}
{"token": ["C0022635#ent", "<e1>", "(", "KP", ")", ",", "a", "nonsteroidal", "anti-inflammatory", "drug", "C3536840#ent", "<e2>", ")", "is", "included", "as", "a", "model", "drug"], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536840", "name": "C3536840#ent", "pos": [10, 11]}}
{"token": ["These", "effects", "required", "GFRalpha1", "but", "neither", "RET", "nor", "C1334863#ent", "<e1>", ",", "the", "two", "transmembrane", "signaling", "receptors", "for", "C1333669#ent", "<e2>", "."], "h": {"id": "C1334863", "name": "C1334863#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333669", "name": "C1333669#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "blocking", "the", "cell", "death", "pathway", "C1516312#ent", "<e1>", "the", "cells", "under-expressing", "C1418270#ent", "<e2>", "from", "only", "some", "of", "the", "stress-induced", "death"], "h": {"id": "C1516312", "name": "C1516312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [12, 13]}}
{"token": ["Recently", "we", "have", "demonstrated", "that", "incubation", "of", "keratinocytes", "with", "C0008373#ent", "<e1>", "granulation", "tissue", "causes", "induction", "of", "gelatinase", "B", "C0623362#ent", "<e2>", "MMP-9", ")", "secretion", "in", "vitro"], "h": {"id": "C0008373", "name": "C0008373#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [18, 19]}}
{"token": ["A", "case", "is", "presented", "in", "which", "a", "woman", "diagnosed", "with", "a", "longstanding", "history", "of", "C0085580#ent", "<e1>", "improvement", "of", "C0239886#ent", "<e2>", "photophobia", ",", "transient", "blindness", "enlarged", "blind", "spots", ",", "and", "tinnitus", "after", "smoking", "marijuana"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0239886", "name": "C0239886#ent", "pos": [18, 19]}}
{"token": ["C0231311#ent", "<e1>", "shift-work", "sleep", "disorder", "and", "some", "of", "the", "C0917801#ent", "<e2>", "caused", "by", "a", "temporal", "discrepancy", "of", "the", "body", "clock", "to", "the", "surrounding", "environment", "and", "social", "network"], "h": {"id": "C0231311", "name": "C0231311#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0917801", "name": "C0917801#ent", "pos": [9, 10]}}
{"token": ["These", "include", "non-seasonal", "depression", ",", "bipolar", "depression", "chronic", "depressive", "disorder", "ante-", "and", "postpartum", "depression", "late", "luteal", "phase", "dysphoric", "disorder", ",", "circadian", "phase", "sleep", "disorders", "C0231311#ent", "<e1>", "shift", "work", "problems", "and", "behavioral", "disturbance", "and", "C0917801#ent", "<e2>", "in", "organic", "dementia"], "h": {"id": "C0231311", "name": "C0231311#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0917801", "name": "C0917801#ent", "pos": [33, 34]}}
{"token": ["Patterns", "of", "bilirubin", "staining", "studied", "in", "nine", "infants", "with", "C0022610#ent", "<e1>", "related", "to", "C0010324#ent", "<e2>", "all", "weighing", "less", "than", "1200", "g", ",", "and", "nine", "matched", "controls"], "h": {"id": "C0022610", "name": "C0022610#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0010324", "name": "C0010324#ent", "pos": [13, 14]}}
{"token": ["The", "laboratory", "features", "C0019693#ent", "<e1>", "resemble", "those", "found", "in", "many", "C0009782#ent", "<e2>", "thus", "alter", "the", "predictive", "value", "these", "tests", "in", "the", "evaluation", "of", "both", "types", "of", "conditions", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [10, 11]}}
{"token": ["RT-PCR", "with", "amplification", "product", "sequence", "analysis", "CYP1A1", ",", "CYP3A4", ",", "CYP1B1", ",", "CYP2E1", ",", "and", "C1828473#ent", "<e1>", "mRNA", "expression", "in", "C0004763#ent", "<e2>"], "h": {"id": "C1828473", "name": "C1828473#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0004763", "name": "C0004763#ent", "pos": [20, 21]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "compare", "the", "efficacy", "of", "C0297635#ent", "<e1>", "and", "ibuprofen", "in", "C0149931#ent", "<e2>", "."], "h": {"id": "C0297635", "name": "C0297635#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [16, 17]}}
{"token": ["Only", "one", "patient", "with", "severe", "primary", "SS", ",", "manifested", "by", "cryoglobulinemia", ",", "vasculitis", "and", "C0156221#ent", "<e1>", ",", "presented", "with", "C0032541#ent", "<e2>", "that", "partially", "responded", "to", "intravenous", "cyclophosphamide", "and", "high-dose", "steroids", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032541", "name": "C0032541#ent", "pos": [19, 20]}}
{"token": ["A", "5", "years", "old", "girl", "with", "C0038220#ent", "<e1>", "treatment", "with", "C0237417#ent", "<e2>", "at", "a", "dose", "of", "30", "mg/kg/day", "and", "Thiopental", "in", "continuous", "IV", "perfusion", "a", "dose", "of", "4", "mg/kg/h", "is", "presented", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0237417", "name": "C0237417#ent", "pos": [10, 11]}}
{"token": ["The", "C0038220#ent", "<e1>", "resolved", "after", "antiepileptic", "therapy", "(", "C0237417#ent", "<e2>", "and", "treatment", "for", "hepatic", "encephalopathy", "Branched", "chain", "amino", "acids", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0237417", "name": "C0237417#ent", "pos": [8, 9]}}
{"token": ["The", "authors", "conclude", "that", "C0700481#ent", "<e1>", ",", "a", "selective", "dopamine1", "(", "DA1", ")", "receptor", "C2987634#ent", "<e2>", ",", "preserves", "blood", "flow", "the", "kidney", "during", "induced", "hypotension", "."], "h": {"id": "C0700481", "name": "C0700481#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", ",", "C1614973#ent", "<e1>", "reduced", "plasma", "C1705543#ent", "<e2>", ",", "but", "not", "cerebrospinal", "fluid", "C1705543#ent", "<e2>", "."], "h": {"id": "C1614973", "name": "C1614973#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [8, 9]}}
{"token": ["Among", "women", "a", "statistically", "significant", "risk", "of", "death", "from", "C0004153#ent", "<e1>", "was", "noted", "(", "C1334533#ent", "<e2>", "=", "286", ")", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334533", "name": "C1334533#ent", "pos": [14, 15]}}
{"token": ["Phenotypic", "analysis", "in", "vivo", "of", "these", "mice", "with", "influenza", "and", "lymphocytic", "choriomeningitis", "viruses", "that", "T", "cell", "differentiation", "peripheral", "T", "cell", "function", "related", "to", "the", "level", "of", "C1706240#ent", "<e1>", "expression", "but", "not", "to", "which", "C1706240#ent", "<e1>", "C0597298#ent", "<e1>", "is", "expressed", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [35, 36]}}
{"token": ["The", "antithrombotic", "efficacy", "of", "the", "prostacyclin", "analogue", "C0164595#ent", "<e1>", "has", "been", "tested", "in", "rabbits", "with", "copper", "C0007274#ent", "<e2>"], "h": {"id": "C0164595", "name": "C0164595#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007274", "name": "C0007274#ent", "pos": [16, 17]}}
{"token": ["As", "pseudopod", "extension", ",", "the", "fluorescent", "signal", "from", "the", "region", "directly", "underlying", "the", "expansion", "zone", "leaving", "a", "C2984553#ent", "<e1>", "in", "the", "C0001614#ent", "<e2>"], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [21, 22]}}
{"token": ["The", "protective", "effect", "200", "mg", "doxantrazole", "given", "orally", "on", "allergen-induced", "bronchoconstriction", "has", "been", "compared", "with", "20", "mg", "C0012694#ent", "<e1>", "DSCG", ")", "in", "15", "patients", "with", "C0004096#ent", "<e2>", "immediate-type", "hypersensitivity"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [25, 26]}}
{"token": ["Preventing", "allergen-induced", "mediator", "release", "from", "mast", "cells", "well", "as", "protection", "of", "smooth", "muscle", "mediators", "already", "released", "can", "both", "explain", "a", "beneficial", "effect", "of", "C0012694#ent", "<e1>", "in", "the", "treatment", "of", "C0004096#ent", "<e2>", "food", "allergy"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [29, 30]}}
{"token": ["Repeat", "exposure", "to", "phthalic", "anhydride", "treatment", "with", "C0012694#ent", "<e1>", "inhibition", "of", "the", "late", "but", "not", "early", "bronchoconstrictive", ",", "C0004096#ent", "<e2>"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [18, 19]}}
{"token": ["Virtually", ",", "all", "the", "in", "vitro", "studies", "isolated", "perfused", "rat", "C0771711#ent", "<e1>", ",", "isolated", "guinea-pig", "islets", "agree", "that", "C0796254#ent", "<e2>", "can", "increase", "both", "basal", "and", "stimulated", "glucagon", "release", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [18, 19]}}
{"token": ["Pentobarbital", "was", "about", "10", "times", "more", "potent", "than", "C0030883#ent", "<e1>", ",", "suggesting", "that", "chloride", "flux", "is", "related", "to", "the", "C0020592#ent", "<e2>", "rather", "than", "anticonvulsant", "actions", "of", "barbiturates", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [19, 20]}}
{"token": ["A", "study", "was", "conducted", "to", "assess", "the", "feasibility", "of", "substituting", "diazepam", "for", "C0030883#ent", "<e1>", "and", "phenobarbital", "in", "C0020592#ent", "<e2>", "withdrawal", "of", "tolerant", "patients", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [17, 18]}}
{"token": ["The", "greater", "sensitivity", "of", "C1333909#ent", "<e1>", "+", "ATPase", "to", "C0031672#ent", "<e2>", "also", "apparent", "when", "deoxycholate-treated", "preparations", "were", "employed", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031672", "name": "C0031672#ent", "pos": [9, 10]}}
{"token": ["Interestingly", ",", "Connexin-43", "and", "C0694872#ent", "<e1>", "show", "expression", "patterns", "similar", "to", "C1428412#ent", "<e2>", ",", "and", "the", "phenotypes", "of", "Connexin-43", "and", "C0694872#ent", "<e1>", "mutants", "resemble", "those", "of", "our", "C1428412#ent", "<e2>", "transgenic", "animals"], "h": {"id": "C1428412", "name": "C1428412#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [4, 5]}}
{"token": ["More", "than", "100", "sites", "cut", "by", "the", "C0014442#ent", "<e1>", "were", "sequenced", "on", "three", "C4049614#ent", "<e2>", "simian", "virus", "40", "DNA", "restriction", "fragments", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4049614", "name": "C4049614#ent", "pos": [13, 14]}}
{"token": ["The", "locations", "of", "the", "bands", "containing", "the", "acetoxyAAF", "for", "each", "C0014442#ent", "<e1>", "overlap", "--", "suggesting", "that", "there", "are", "regions", "on", "C4049614#ent", "<e2>", "contain", "high", "affinity", "sites", "for", "acetoxyAAF", "binding", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4049614", "name": "C4049614#ent", "pos": [20, 21]}}
{"token": ["The", "therapeutic", "utility", "of", "these", "C0035064#ent", "<e1>", "supports", "biogenic", "amine", "theories", "affective", "disorders", "raises", "the", "question", "as", "to", "whether", "C1420214#ent", "<e2>", "and", "NET", "exhibit", "a", "functional", "genetic", "variation", "could", "influence", "risk", "for", "behavioral", "disorders"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420214", "name": "C1420214#ent", "pos": [19, 20]}}
{"token": ["These", "C0042373#ent", "<e1>", ",", "often", "detected", "in", "patients", "with", "C0024141#ent", "<e2>", "at", "autopsy", ",", "seem", "to", "alter", "the", "clinical", "course"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [9, 10]}}
{"token": ["Using", "the", "appropriate", "'", "C0211705#ent", "<e1>", "inactive", "'", "mutant", "receptors", "we", "show", "that", "ligand-induced", "activation", "of", "C1822773#ent", "<e2>", "results", "in", "transphosphorylation", "of", "Ron", ",", "and", "vice", "versa", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1822773", "name": "C1822773#ent", "pos": [16, 17]}}
{"token": ["ETV1", "also", "bound", "to", "the", "Rcl", "promoter", "in", "vivo", "indicating", "that", "C1427424#ent", "<e1>", "is", "a", "bona", "fide", "target", "C0079429#ent", "<e2>", "of", "ETV1", "."], "h": {"id": "C1427424", "name": "C1427424#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}}
{"token": ["The", "switch", "from", "C1419394#ent", "<e1>", "to", "H1", "receptors", "differentiation", "in", "the", "C1258847#ent", "<e2>", "lineage", "could", "participate", "in", "the", "pathogenic", "processes", "atherosclerosis", "and", "inflammatory", "reactions", "the", "arterial", "wall"], "h": {"id": "C1419394", "name": "C1419394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [11, 12]}}
{"token": ["The", "identification", "of", "C1418445#ent", "<e1>", "as", "the", "causative", "gene", "molecular", "screening", "enabled", "a", "re-evaluation", "of", "the", "C1848862#ent", "<e2>", "to", "identify", "potential", "diagnostic", "characteristics", "."], "h": {"id": "C1418445", "name": "C1418445#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [16, 17]}}
{"token": ["The", "primary", "objective", "to", "assess", "the", "safety", "of", "C0937846#ent", "<e1>", "40", "mg", "once", "daily", "in", "adolescents", "with", "clinically", "diagnosed", "gastroesophageal", "reflux", "disease", "C0017168#ent", "<e2>", ")", "."], "h": {"id": "C0937846", "name": "C0937846#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [22, 23]}}
{"token": ["The", "peak", "of", "serum", "IL-12", "occurs", "after", "the", "C0019159#ent", "<e1>", "precedes", "or", "coincides", "with", "the", "time", "of", "C1415484#ent", "<e2>", "seroconversion", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415484", "name": "C1415484#ent", "pos": [17, 18]}}
{"token": ["This", "C1456377#ent", "<e1>", "process", "is", "governed", "by", "SV40", "large", "T", "antigen", "HSV-encoded", "DNA", "replication", "factors", "e.g.", ",", "C0012892#ent", "<e2>", "single-strand", "binding", "protein", "SSB", ")", ",", "and", "helicase-primase", "."], "h": {"id": "C1456377", "name": "C1456377#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [17, 18]}}
{"token": ["Clinical", "trials", "date", "have", "demonstrated", "that", "Epo", "therapy", "correct", "the", "anemias", "of", "C0035078#ent", "<e1>", "of", "rheumatoid", "arthritis", "and", "of", "C0001175#ent", "<e2>", "AIDS", ")", "patients", "undergoing", "antiviral", "therapy"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [19, 20]}}
{"token": ["These", "features", "are", "compatible", "with", "C0001339#ent", "<e1>", "secondary", "to", "C3495132#ent", "<e2>", "infestation", "."], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3495132", "name": "C3495132#ent", "pos": [9, 10]}}
{"token": ["In", "the", "VWF(+", ")", "group", ",", "plasma", "C1706331#ent", "<e1>", "concentrations", "were", "normal", "but", "plasma", "TAT", "and", "C0730321#ent", "<e2>", "levels", "were", "significantly", "elevated", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0730321", "name": "C0730321#ent", "pos": [16, 17]}}
{"token": ["TaPHYC", "C0079429#ent", "<e1>", "shares", "structural", "similarities", "with", "the", "rice", "C0020207#ent", "<e2>", "containing", "four", "exons", "and", "three", "introns", "in", "the", "coding", "region"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020207", "name": "C0020207#ent", "pos": [9, 10]}}
{"token": ["Although", "psychosis", ",", "C0036572#ent", "<e1>", "and", "meningitis", "are", "common", "central", "nervous", "system", "CNS", ")", "manifestations", "in", "C0024141#ent", "<e2>", "patients", ",", "Parkinsonian-like", "symptoms", "extremely", "rare", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [16, 17]}}
{"token": ["Transferases", ",", "including", "the", "glutathione", "S-transferases", "C0796518#ent", "<e1>", ",", "UDP-glucuronosyltransferases", ",", "microsomal", "and", "cytosolic", "epoxide", "hydrolases", "and", "C1136197#ent", "<e2>", "also", "significant", "in", "xenobiotic", "metabolism", "can", "play", "a", "role", "in", "chemical", "sensitivities"], "h": {"id": "C0796518", "name": "C0796518#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [17, 18]}}
{"token": ["While", "axonal", "changes", "predominated", "in", "some", "IHPS", "cases", "there", "were", "severe", "changes", "of", "smooth", "muscle", "cells", "others", "suggesting", "that", "a", "primarily", "C1859721#ent", "<e1>", "IHPS", "can", "be", "distinguished", "from", "a", "predominantly", "C1417575#ent", "<e2>"], "h": {"id": "C1859721", "name": "C1859721#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1417575", "name": "C1417575#ent", "pos": [30, 31]}}
{"token": ["In", "the", "C0054434#ent", "<e1>", "rats", ",", "ileum", "tissue", "levels", "of", "malondialdehyde", "and", "C1417245#ent", "<e2>", "were", "significantly", "lower", "than", "those", "of", "the", "bile", "duct-ligated", "rats", "(", "P", "<", "0.001", ")", "."], "h": {"id": "C0054434", "name": "C0054434#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417245", "name": "C1417245#ent", "pos": [12, 13]}}
{"token": ["C1121571#ent", "<e1>", "PON1", ")", "is", "reported", "to", "have", "antioxidant", "and", "C0007209#ent", "<e2>"], "h": {"id": "C1121571", "name": "C1121571#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [10, 11]}}
{"token": ["This", "function", "is", "dominant", ",", "and", "C3554224#ent", "<e1>", "results", "in", "a", "high", "bone", "mass", "phenotype", "despite", "the", "C0020619#ent", "<e2>", "characterizing", "these", "animals", "."], "h": {"id": "C3554224", "name": "C3554224#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0020619", "name": "C0020619#ent", "pos": [17, 18]}}
{"token": ["In", "addition", "to", "its", "effects", "on", "body", "weight", "chronic", "leptin", "treatment", "restores", "puberty", "and", "fertility", "to", "ob/ob", "mice", "total", "C3554224#ent", "<e1>", "and", "acute", "treatment", "corrects", "C0020619#ent", "<e2>", "in", "mice", "starved", "for", "2", "d", "without", "affecting", "body", "weight"], "h": {"id": "C3554224", "name": "C3554224#ent", "pos": [19, 20]}, "relation": "has_manifestation", "t": {"id": "C0020619", "name": "C0020619#ent", "pos": [25, 26]}}
{"token": ["We", "previously", "showed", "that", "a", "point", "mutation", "R105W", ")", "in", "leptin", "results", "in", "C3554224#ent", "<e1>", "marked", "obesity", "and", "C0020619#ent", "<e2>", "in", "humans", "adults", "."], "h": {"id": "C3554224", "name": "C3554224#ent", "pos": [13, 14]}, "relation": "has_manifestation", "t": {"id": "C0020619", "name": "C0020619#ent", "pos": [18, 19]}}
{"token": ["The", "myocyte", "enhancer", "factor-2", "C1705446#ent", "<e1>", ")", "family", "of", "C0001477#ent", "<e2>", "transcription", "factors", "neuronal", "development", "controlling", "synapse", "formation", "and", "supporting", "the", "survival", "of", "newly", "formed", "neurons", "."], "h": {"id": "C1705446", "name": "C1705446#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [9, 10]}}
{"token": ["NMDA", "treatment", "resulted", "in", "an", "increase", "in", "the", "phosphorylation", "of", "C1705446#ent", "<e1>", "in", "the", "absence", "or", "presence", "of", "external", "C0001477#ent", "<e2>"], "h": {"id": "C1705446", "name": "C1705446#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [19, 20]}}
{"token": ["With", "this", "method", ",", "we", "discovered", "70", "C0079941#ent", "<e1>", "with", "evidence", "for", "preferential", "expression", "of", "one", "C1706112#ent", "<e2>", "in", "a", "diploid", "hybrid", "two", "S.", "cerevisiae", "strains", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [16, 17]}}
{"token": ["While", "C0013720#ent", "<e1>", "caused", "by", "a", "mutation", "in", "the", "collagen", "III", "gene", "in", "C0268342#ent", "<e2>", "mutation", "in", "the", "lysyl", "hydroxylase", "gene", "present", "."], "h": {"id": "C0013720", "name": "C0013720#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268342", "name": "C0268342#ent", "pos": [13, 14]}}
{"token": ["Two", "sibs", "with", "the", "C0013720#ent", "<e1>", "one", "of", "whom", "was", "shown", "to", "have", "C0268342#ent", "<e2>", "are", "described", "."], "h": {"id": "C0013720", "name": "C0013720#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268342", "name": "C0268342#ent", "pos": [13, 14]}}
{"token": ["The", "D1/D5", "receptor", "antagonist", "SCH-23390", ",", "the", "C1414805#ent", "<e1>", "inhibitor", "rapamycin", ",", "and", "the", "protein", "synthesis", "C0001641#ent", "<e2>", "anisomycin", "suppressed", "this", "effect", "."], "h": {"id": "C1414805", "name": "C1414805#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [16, 17]}}
{"token": ["Even", "in", "small", "lesions", "C3813556#ent", "<e1>", "can", "locate", "the", "C1825626#ent", "<e2>", "of", "the", "needle", "."], "h": {"id": "C3813556", "name": "C3813556#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1825626", "name": "C1825626#ent", "pos": [9, 10]}}
{"token": ["C0991617#ent", "<e1>", "which", "affect", "the", "C1414387#ent", "<e2>", "phosphorylation", "state", "of", "cell", "proteins", "not", "alter", "CytPTK", "activity", "when", "subjected", "to", "intact", "adepocytes", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [5, 6]}}
{"token": ["However", ",", "it", "is", "clear", "that", "the", "p53", "response", "is", "normal", "in", "these", "cells", "after", "exposure", "to", "C0991617#ent", "<e1>", "and", "it", "is", "mediated", "through", "protein", "kinase", "C", "another", "C1414387#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [28, 29]}}
{"token": ["Expression", "of", "HIRc", "receptors", "cells", "led", "to", "enhanced", "sensitivity", "to", "insulin", "of", "C0011501#ent", "<e1>", "uptake", "and", "C0017932#ent", "<e2>", "activation", "."], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [16, 17]}}
{"token": ["A", "C0018995#ent", "<e1>", "deficiency", "of", "neuraminidase", "activity", "C0026697#ent", "<e2>", "was", "confirmed", "."], "h": {"id": "C0018995", "name": "C0018995#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026697", "name": "C0026697#ent", "pos": [7, 8]}}
{"token": ["In", "man", "two", "genetically", "distinct", "C0018995#ent", "<e1>", "associated", "with", "a", "primary", "or", "a", "secondary", "deficiency", "of", "lysosomal", "neuraminidase", "C0026697#ent", "<e2>", "and", "galactosialidosis", "."], "h": {"id": "C0018995", "name": "C0018995#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026697", "name": "C0026697#ent", "pos": [18, 19]}}
{"token": ["Of", "29", "selected", "patients", "with", "C0009186#ent", "<e1>", "27", "were", "treated", "for", "at", "least", "6", "months", "with", "C0022625#ent", "<e2>", ",", "200", "to", "600", "mg/d", "."], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [16, 17]}}
{"token": ["Of", "note", ",", "3", "patients", "developed", "C0009186#ent", "<e1>", "while", "receiving", "C0022625#ent", "<e2>", "for", "other", "conditions.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [10, 11]}}
{"token": ["With", "other", "more", "chronic", "manifestations", "C0009186#ent", "<e1>", ",", "treatment", "with", "fluconazole", ",", "itraconazole", ",", "or", "C0022625#ent", "<e2>", "is", "common", "."], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [15, 16]}}
{"token": ["However", ",", "melanoma", "cell-associated", "C1332729#ent", "<e1>", "breakdown", "was", "not", "sensitive", "to", "C0251991#ent", "<e2>", ",", "an", "inhibitor", "of", "phosphatidylinositol-3-kinase", "(", "PI3K", ",", "whereas", "inhibition", "of", "PI3K", "in", "a", "reduction", "of", "melanoma", "cell", "."], "h": {"id": "C1332729", "name": "C1332729#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0251991", "name": "C0251991#ent", "pos": [11, 12]}}
{"token": ["130", "nm", "in", "average", "diameter", "C3252090#ent", "<e1>", ")", "were", "abundant", "in", "the", "C1423498#ent", "<e2>", "suggesting", "their", "formation", "at", "this", "site", "."], "h": {"id": "C3252090", "name": "C3252090#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1423498", "name": "C1423498#ent", "pos": [12, 13]}}
{"token": ["C0016365#ent", "<e1>", "substantially", "inhibits", "C3887685#ent", "<e2>", "and", "probably", "CYP2C9/10", ",", "moderately", "inhibits", "CYP2C19", "and", "mildly", "inhibits", "CYP3A3/4", "."], "h": {"id": "C0016365", "name": "C0016365#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [4, 5]}}
{"token": ["The", "plasma", "concentrations", "of", "C0016365#ent", "<e1>", "and", "norfluoxetine", "enantiomers", "were", "measured", "and", "C3887685#ent", "<e2>", ",", "CYP2C9", "and", "CYP2C19", "genotypes", "were", "analyzed", "."], "h": {"id": "C0016365", "name": "C0016365#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [12, 13]}}
{"token": ["Overall", "these", "data", "indicate", "that", "C1428880#ent", "<e1>", "induction", "by", "C1332729#ent", "<e2>", "and", "VEGF", "in", "endothelial", "cells", "activation", "of", "PI3-kinase", "."], "h": {"id": "C1428880", "name": "C1428880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332729", "name": "C1332729#ent", "pos": [9, 10]}}
{"token": ["Dictyostelium", "cell", "lines", "expressing", "inactive", "(", "N128I", "mutant", ")", "and", "C0907533#ent", "<e1>", "active", "(", "Q74L", "mutant", ")", "C0265216#ent", "<e2>", "as", "green", "fluorescent", "protein", "chimeras", "were", "generated", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0265216", "name": "C0265216#ent", "pos": [17, 18]}}
{"token": ["According", "steroidogenic", "enzyme", ",", "we", "evaluated", "temporal", "and", "spatial", "localization", "cholesterol", "side", "chain", "cleavage", "scc", ")", ",", "3", "beta", "hydroxysteroid", "dehydrogenase", "3", "beta", "HSD", ")", ",", "17", "C0038315#ent", "<e1>", "17", "alpha", ")", "and", "C0003805#ent", "<e2>", ",", "and", "steroid", "receptors"], "h": {"id": "C0038315", "name": "C0038315#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [33, 34]}}
{"token": ["Also", ",", "C1417693#ent", "<e1>", "and", "the", "C4255049#ent", "<e2>", "c-Fos", "and", "c-Jun", "are", "all", "activated", "by", "high", "NaCl", "."], "h": {"id": "C1417693", "name": "C1417693#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4255049", "name": "C4255049#ent", "pos": [6, 7]}}
{"token": ["In", "a", "recent", "report", "we", "have", "shown", "that", "C3811749#ent", "<e1>", "represses", "Cyclin", "D1", "transcription", "through", "recruitment", "of", "C1334032#ent", "<e2>", "dependent", "repressor", "complex", "the", "MAR", "site", "Cyclin", "D1", "promoter", "."], "h": {"id": "C3811749", "name": "C3811749#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [17, 18]}}
{"token": ["In", "the", "current", "study", ",", "we", "examined", "for", "allelic", "deletion", "at", "the", "C0919457#ent", "<e1>", "locus", "in", "58", "primary", "and", "microdissected", "C1704939#ent", "<e2>", ",", "for", "which", "a", "clinicopathologic", "profile", "was", "available", "."], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [20, 21]}}
{"token": ["We", "studied", "C0919457#ent", "<e1>", "methylation", "in", "254", "C1704939#ent", "<e2>", "in", "order", "to", "further", "understand", "the", "clinicopathological", "and", "prognostic", "significance", "C0919457#ent", "<e1>", "methylation", "in", "NSCLC", "."], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [7, 8]}}
{"token": ["C0919457#ent", "<e1>", "methylation", "was", "detected", "in", "37", "%", "of", "primary", "C1704939#ent", "<e2>", ",", "31", "%", "of", "primary", "breast", "cancers", "and", "65", "%", "of", "lung", "and", "86", "%", "of", "breast", "cancer", "cell", "lines"], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [10, 11]}}
{"token": ["The", "boy", "is", "quite", "healthy", "and", "C0014544#ent", "<e1>", "is", "under", "control", "of", "C0015043#ent", "<e2>", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [12, 13]}}
{"token": ["The", "occurrence", "of", "generalised", "tonic-clonic", "seizures", "GTCS", ")", "was", "investigated", "in", "patients", "with", "absence", "C0014544#ent", "<e1>", "(", "AE", ")", ",", "evaluating", "the", "opinion", "that", "C0015043#ent", "<e2>", "does", "not", "protect", "against", "GTCS", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [24, 25]}}
{"token": ["Ethosuximide", "is", "a", "medication", "used", "to", "treat", "C0014544#ent", "<e1>", "humans", ",", "and", "we", "previously", "demonstrated", "that", "C0015043#ent", "<e2>", "can", "delay", "age-related", "changes", "and", "extend", "the", "lifespan", "of", "the", "nematode", "Caenorhabditis", "elegans"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [16, 17]}}
{"token": ["Although", "difficulties", "exist", "in", "evaluating", "clinical", "trials", "allergic", "eye", "disease", "both", "open", "and", "controlled", "studies", "shown", "ocular", "sodium", "cromoglycate", "be", "very", "effective", "in", "relieving", "the", "C1457887#ent", "<e1>", "clinical", "signs", "the", "above", "C0730362#ent", "<e2>"], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0730362", "name": "C0730362#ent", "pos": [31, 32]}}
{"token": ["C1533698#ent", "<e1>", "iNOS", ")", "is", "implicated", "in", "the", "pathogenesis", "of", "acute", "respiratory", "distress", "syndrome", "C0035222#ent", "<e2>", ")", "."], "h": {"id": "C1533698", "name": "C1533698#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [14, 15]}}
{"token": ["Novel", "prostate", "cancer", "associations", "for", "several", "well", "characterized", "genes", "or", "full", "length", "cDNAs", "were", "identified", ",", "including", "C1418709#ent", "<e1>", ",", "JM27", ",", "human", "UbcM2", ",", "dynein", "light", "intermediate", "chain", "2", "human", "C1334043#ent", "<e2>", "of", "rat", "sec61", "."], "h": {"id": "C1418709", "name": "C1418709#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [31, 32]}}
{"token": ["The", "dystrophinopathies", ",", "which", "include", "Duchenne", "muscular", "dystrophy", "DMD", ")", ",", "C0917713#ent", "<e1>", "BMD", ")", ",", "and", "C3668940#ent", "<e2>", "are", "X-linked", "recessive", "neuromuscular", "disorders", "by", "mutations", "in", "the", "dystrophin", "gene", "DMD", ")", "."], "h": {"id": "C0917713", "name": "C0917713#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3668940", "name": "C3668940#ent", "pos": [17, 18]}}
{"token": ["Other", "dystrophinopathies", "include", "the", "similar", "but", "somewhat", "milder", "C0917713#ent", "<e1>", "BMD", ")", "and", "C3668940#ent", "<e2>", "XLDCM", ")", "where", "the", "cardiac", "manifestations", "."], "h": {"id": "C0917713", "name": "C0917713#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3668940", "name": "C3668940#ent", "pos": [13, 14]}}
{"token": ["We", "studied", "the", "C0020616#ent", "<e1>", "effects", "of", "cibenzoline", ",", "a", "C0003195#ent", "<e2>"], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [10, 11]}}
{"token": ["Our", "data", "suggest", "that", "the", "N.", "gonorrhoeae", "isolate", "used", "in", "this", "work", "has", "C2347054#ent", "<e1>", "related", "activity", "which", "participates", "in", "the", "C1951340#ent", "<e2>", "of", "its", "adherence", "to", "rabbit", "mesentery", "cells"], "h": {"id": "C2347054", "name": "C2347054#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1951340", "name": "C1951340#ent", "pos": [21, 22]}}
{"token": ["C0020550#ent", "<e1>", "defined", "as", "a", "situation", "where", "the", "levels", "of", "the", "C4273673#ent", "<e2>", "normal", "but", "serum", "thyrotropin", "TSH", ")", "is", "low", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4273673", "name": "C4273673#ent", "pos": [11, 12]}}
{"token": ["At", "higher", "lung", "volumes", "Vtis", "increases", "offset", "falls", "in", "Raw", ",", "producing", "higher", "C1419337#ent", "<e1>", "at", "these", "volumes", "before", "and", "during", "constriction", "with", "C0058310#ent", "<e2>", "histamine", "."], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [23, 24]}}
{"token": ["All", "forms", "of", "botulism", "cause", "progressive", "weakness", ",", "bulbar", "signs", "blurred", "vision", "diplopia", ",", "mydriasis", ",", "C0011168#ent", "<e1>", ",", "and", "dysarthria", ")", ",", "and", "C1145670#ent", "<e2>", "normal", "sensation", "mentation", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [24, 25]}}
{"token": ["Compression", "of", "trachea", "and", "esophagus", ",", "accompanied", "by", "dyspnea", ",", "inspiratory", "stridor", "and", "C0011168#ent", "<e1>", ",", "led", "to", "a", "progressive", "cachexia", "and", "premature", "death", "to", "C1145670#ent", "<e2>"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [25, 26]}}
{"token": ["Potentially", "these", "C0030956#ent", "<e1>", "are", "less", "likely", "to", "cause", "adverse", "reactions", "C3274161#ent", "<e2>", "sensitive", "patients", "and", "thus", "offer", "a", "new", "approach", "to", "allergen", "immunotherapy"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [11, 12]}}
{"token": ["Immunotherapy", "with", "C0030956#ent", "<e1>", "containing", "major", "T-cell", "epitopes", "the", "relevant", "C3274161#ent", "<e2>", "or", "allergens", "provides", "an", "alternative", "strategy", "without", "these", "problems", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [10, 11]}}
{"token": ["Amino-acid-sequence", "data", "have", "been", "obtained", "from", "C0030956#ent", "<e1>", "produced", "by", "CNBr", "treatment", "of", "the", "native", "C3274161#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [15, 16]}}
{"token": ["In", "the", "last", "years", "the", "C0022541#ent", "<e1>", "has", "been", "defined", "with", "the", "typical", "trias", "of", "C0162292#ent", "<e2>", "pigmentary", "retinal", "dystrophy", "cardiac", "conduction", "defects", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162292", "name": "C0162292#ent", "pos": [15, 16]}}
{"token": ["C0003864#ent", "<e1>", "complicating", "the", "common", "viral", "infections", "C0026780#ent", "<e2>", ",", "coxsackievirus", ",", "and", "adenovirus", "--", "can", "be", "enigmatic", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026780", "name": "C0026780#ent", "pos": [7, 8]}}
{"token": ["The", "episode", "was", "characterized", "by", "a", "vasculitic", "skin", "rash", "associated", "with", "C0003864#ent", "<e1>", "pyrexia", "and", "C0026780#ent", "<e2>", "but", "no", "renal", "or", "pulmonary", "involvement", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026780", "name": "C0026780#ent", "pos": [15, 16]}}
{"token": ["These", "regulated", "genes", "belonged", "to", "different", "families", "of", "C0127400#ent", "<e1>", "their", "receptors", ",", "transcription", "factors", "C0010536#ent", "<e2>", ",", "matrix", "proteins", "their", "inhibitors", ",", "ion", "channels", "transporters", ",", "and", "proteins", "involved", "in", "cell", "metabolic", "pathways"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [15, 16]}}
{"token": ["Targets", "for", "inhibition", "include", "matrix", "metalloproteinases", "C0127400#ent", "<e1>", "of", "signal", "transduction", "tyrosine", "kinases", "cyclin", "dependent", "kinases", "other", "C0010536#ent", "<e2>", "such", "as", "protein", "kinase", "C", "A", ")", "as", "well", "as", "ras", "expression", "and", "prenylation", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [17, 18]}}
{"token": ["Causes", "of", "hemobilia", "include", "trauma", ";", "gallstones", ";", "inflammatory", "diseases", "and", "vascular", "disorders", "as", "C0751003#ent", "<e1>", ",", "tumor", ",", "and", "C0012739#ent", "<e2>", "."], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [20, 21]}}
{"token": ["However", ",", "cases", "with", "large", "and", "expanding", "C0751003#ent", "<e1>", "are", "especially", "prone", "for", "this", "C0012739#ent", "<e2>", "."], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [14, 15]}}
{"token": ["C0085096#ent", "<e1>", "the", "extremities", "causes", "C0002962#ent", "<e2>", ",", "at", "times", ",", "skin", "ulcerations", "gangrene", "."], "h": {"id": "C0085096", "name": "C0085096#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [5, 6]}}
{"token": ["For", "those", "antiarrhythmic", "drugs", "both", "sodium", "and", "potassium", "channel", "blockade", "e.g.", "C0002598#ent", "<e1>", ")", ",", "the", "effect", "of", "C1412114#ent", "<e2>", "blockade", "predominates", ",", "resulting", "in", "an", "increase", "in", "DFT", "."], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412114", "name": "C1412114#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "suggested", "that", "C0002598#ent", "<e1>", ",", "like", "lignocaine", ",", "blocks", "the", "C1412114#ent", "<e2>", "when", "it", "is", "in", "the", "inactivated", "state", "."], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412114", "name": "C1412114#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "four", "patients", "with", "C0038220#ent", "<e1>", "were", "successfully", "treated", "with", "C0026056#ent", "<e2>"], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [11, 12]}}
{"token": ["C0038220#ent", "<e1>", "terminated", "with", "C0026056#ent", "<e2>", "alone", "in", "58", "patients", ",", "with", "the", "addition", "of", "phenytoin", "in", "19", "patients", "and", "with", "continuous", "midazolam", "in", "32", "patients", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [4, 5]}}
{"token": ["All", "patients", "with", "a", "history", "of", "C0038220#ent", "<e1>", "prescribed", "rectal", "diazepam", "or", ",", "more", "rarely", ",", "C0026056#ent", "<e2>"], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [16, 17]}}
{"token": ["In", "this", "regard", ",", "only", "cells", "transformed", "by", "mutated", "cellular", "and", "viral", "H-ras", "oncogenes", "but", "not", "by", "the", "C0033713#ent", "<e1>", "had", "elevated", "C0011967#ent", "<e2>", "levels", "compared", "to", "contact", "inhibited", "NIH/3T3", "cells"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [22, 23]}}
{"token": ["Mitogen-activated", "protein", "MAP", ")", "C0096069#ent", "<e1>", "MKP-3", ")", "is", "a", "dual", "specificity", "phosphatase", "that", "inactivates", "C4082284#ent", "<e2>", "ERK", ")", "MAP", "kinases"], "h": {"id": "C0096069", "name": "C0096069#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [15, 16]}}
{"token": ["VGCC", "dysfunction", "may", "also", "underlie", "acquired", "peripheral", "and", "central", "nervous", "system", "diseases", "associated", "with", "small-cell", "lung", "cancer", "including", "C0022972#ent", "<e1>", "LEMS", ")", "and", "C0393534#ent", "<e2>", "PCA", ")", "."], "h": {"id": "C0022972", "name": "C0022972#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0393534", "name": "C0393534#ent", "pos": [23, 24]}}
{"token": ["PI3K", "inhibitor", "C0251991#ent", "<e1>", ")", "prevented", "pressure-stimulated", "Akt", "Ser473", "and", "C1704657#ent", "<e2>", "Tyr397", ",", "but", "not", "FAK576", "or", "Src416", "phosphorylation", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704657", "name": "C1704657#ent", "pos": [10, 11]}}
{"token": ["The", "second", "C1427590#ent", "<e1>", "Smac", ",", "is", "an", "C1419987#ent", "<e2>"], "h": {"id": "C1427590", "name": "C1427590#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419987", "name": "C1419987#ent", "pos": [8, 9]}}
{"token": ["Low", "bone", "mineral", "density", "C0339510#ent", "<e1>", ")", "is", "a", "common", "secondary", "condition", "associated", "with", "C3495559#ent", "<e2>", "JIA", ")", "."], "h": {"id": "C0339510", "name": "C0339510#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "the", "blood", "pressure", "effects", "of", "C1950687#ent", "<e1>", "aliskiren", ",", "alone", "or", "in", "combination", "with", "the", "angiotensin", "receptor", "blocker", "C0216784#ent", "<e2>", "."], "h": {"id": "C1950687", "name": "C1950687#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0216784", "name": "C0216784#ent", "pos": [20, 21]}}
{"token": ["Based", "on", "measured", "variability", "in", "C3814396#ent", "<e1>", "enzyme", "expression", "levels", "and", "plasma", "orosomucoid", "C1422763#ent", "<e2>", ")", "concentrations", ",", "a", "Monte-Carlo-based", "simulation", "of", "methadone", "kinetics", "in", "a", "pediatric", "population", "performed", "."], "h": {"id": "C3814396", "name": "C3814396#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422763", "name": "C1422763#ent", "pos": [13, 14]}}
{"token": ["In", "the", "immunocompromised", "host", ",", "this", "organism", "was", "observed", "as", "the", "sole", "C1875400#ent", "<e1>", "in", "cases", "of", "persistent", "C0014009#ent", "<e2>", "and/or", "overwhelming", "pneumonias", "with", "bacteremias", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014009", "name": "C0014009#ent", "pos": [18, 19]}}
{"token": ["The", "cell", "cycle", "proteins", "associated", "with", "tumors", "were", "C1414229#ent", "<e1>", ",", "cyclins", "A", "B1", "and", "E", ",", "SKP2", "and", "C0256022#ent", "<e2>"], "h": {"id": "C1414229", "name": "C1414229#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0256022", "name": "C0256022#ent", "pos": [19, 20]}}
{"token": ["Dose-related", "adverse", "events", "liposomal", "anthracycline", "therapy", "include", "stomatitis", "and", "C0027947#ent", "<e1>", ",", "and", "more", "frequent", "doses", "of", "C0388638#ent", "<e2>", "are", "associated", "with", "hand-foot", "syndrome"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "C1306759#ent", "<e1>", "on", "the", "course", "of", "C0024530#ent", "<e2>", "mice", "were", "studied", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "levodopa", ",", "apomorphine", "and", "C0917718#ent", "<e1>", "(", "DOPS", ")", "on", "C3543842#ent", "<e2>", "seizures", "elicited", "by", "strychnine", "were", "investigated", "in", "mice", "."], "h": {"id": "C0917718", "name": "C0917718#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "TcTAT", "is", "C3890227#ent", "<e1>", "in", "strains", "of", "the", "parasite", "that", "are", "resistant", "to", "C0053230#ent", "<e2>", "(", "BZ", ")", ",", "a", "drug", "currently", "used", "in", "chemotherapy", "."], "h": {"id": "C3890227", "name": "C3890227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0053230", "name": "C0053230#ent", "pos": [15, 16]}}
{"token": ["C0030956#ent", "<e1>", "by", "either", "conjugate", "was", "accessible", "to", "C1522555#ent", "<e2>", "demonstrated", "by", "the", "efficient", "phosphorylation", "of", "the", "peptide", "when", "the", "appropriate", "kinase", "was", "active", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522555", "name": "C1522555#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "biallelic", "mutations", "in", "BRCA2", ",", "C1880731#ent", "<e1>", ",", "and", "PALB2", "cause", "C0015625#ent", "<e2>"], "h": {"id": "C1880731", "name": "C1880731#ent", "pos": [8, 9]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [14, 15]}}
{"token": ["Several", "chimeric", "proteins", "as", "AML1-MTG8", "and", "C0919449#ent", "<e1>", "have", "transdominant", "properties", "for", "C2987364#ent", "<e2>", "AML1", "and", "acts", "as", "transcriptional", "repressors"], "h": {"id": "C0919449", "name": "C0919449#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}}
{"token": ["Major", "changes", "in", "the", "expression", "of", "citrate", "synthase", "lactate", "dehydrogenase", "proteasome", ",", "C0291573#ent", "<e1>", "plasminogen", "activators", "PAs", ")", ",", "and", "C0623362#ent", "<e2>", "MMP2", "-", "9", ")", "were", "observed", "upon", "serum", "stimulation", "but", "no", "age-related", "difference", "noted", "."], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [20, 21]}}
{"token": ["C1161331#ent", "<e1>", "gradient", "centrifugation", "of", "the", "lipid", "droplets", "the", "C0023899#ent", "<e2>", "from", "the", "enteral", "group", "an", "increase", "of", "the", "free-triacylglycerol", "fraction", "with", "a", "concomitant", "increase", "of", "the", "apoprotein", "B-48-rich", "triacylglycerol", "fraction", "."], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "ethanol", "or", "C1161331#ent", "<e1>", "administration", "to", "rats", "on", "acetylcholinesterase", "from", "brain", "and", "C0023899#ent", "<e2>", "were", "investigated", "."], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [15, 16]}}
{"token": ["Diabetes", "also", "induces", "peculiar", "C0221021#ent", "<e1>", "changes", "leading", "to", "diabetic", "nephropathy", "to", "end-stage", "renal", "failure", "and", "to", "C0011884#ent", "<e2>", "may", "progress", "to", "vision", "loss", "blindness", "."], "h": {"id": "C0221021", "name": "C0221021#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [17, 18]}}
{"token": ["The", "clinical", "pattern", "corneal", "calcification", "been", "considered", "to", "be", "a", "part", "of", "C0015397#ent", "<e1>", "such", "as", "uveitis", ",", "severe", "C0017601#ent", "<e2>", ",", "keratitis", "and", "eye", "burns"], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [19, 20]}}
{"token": ["None", "of", "these", "polymorphisms", "were", "cosegregating", "with", "C1837790#ent", "<e1>", "rendering", "a", "disease", "causing", "mutation", "in", "the", "C1418946#ent", "<e2>", "gene", "unlikely", "."], "h": {"id": "C1837790", "name": "C1837790#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418946", "name": "C1418946#ent", "pos": [16, 17]}}
{"token": ["Neither", "mean", "C0919455#ent", "<e1>", ",", "systolic", "RAD", "and", "diastolic", "C0919455#ent", "<e1>", "nor", "mean", "C1414063#ent", "<e1>", ",", "systolic", "LAD", "diastolic", "LAD", "significantly", "."], "h": {"id": "C0919455", "name": "C0919455#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414063", "name": "C1414063#ent", "pos": [13, 14]}}
{"token": ["We", "show", "that", "retroviral", "gene", "transfer", "thymidylate", "synthase", "TS", ")", "confers", "resistance", "to", "TS", "directed", "anticancer", "agents", "that", "co-expression", "of", "TS", "and", "dihydrofolate", "reductase", "C0039667#ent", "<e1>", ")", "confers", "resistance", "to", "TS", "and", "C0039667#ent", "<e1>", "C0304497#ent", "<e1>"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0304497", "name": "C0304497#ent", "pos": [34, 35]}}
{"token": ["We", "addressed", "the", "question", "whether", "M-CSF", "regulates", "C1704657#ent", "<e1>", "phosphorylation", "in", "macrophages", ",", "and", "found", "that", "M-CSF", "induces", "C0059239#ent", "<e2>", "phosphorylation", "at", "all", "known", "tyrosine", "residues", "."], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [18, 19]}}
{"token": ["Experimental", "clustering", "chimeras", "containing", "integrin", "beta", "cytoplasmic", "domains", "C0059239#ent", "<e1>", "induced", "C1704657#ent", "<e2>", "phosphorylation", "and", "trans-phosphorylation", "of", "endogenous", "C0059239#ent", "<e1>", ",", "as", "well", "as", "strong", "ERK", "activation", "."], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [8, 9]}}
{"token": ["TNF-alpha", "is", "a", "proinflammatory", "cytokine", "involved", "in", "many", "inflammatory", "conditions", "as", "Crohn's", "disease", "rheumatoid", "arthritis", "C0006625#ent", "<e1>", ",", "AIDS", ",", "and", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", "."], "h": {"id": "C0006625", "name": "C0006625#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [23, 24]}}
{"token": ["Drugs", "that", "are", "potent", "inhibitors", "of", "[3H]tryptamine", "binding", "include", "C0077436#ent", "<e1>", ",", "quipazine", ",", "phenylethylamine", ",", "amphetamine", ",", "C0030131#ent", "<e2>", "and", "methamphetamine", "."], "h": {"id": "C0077436", "name": "C0077436#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030131", "name": "C0030131#ent", "pos": [18, 19]}}
{"token": ["There", "were", "86", "with", "C0004096#ent", "<e1>", "without", "C0008677#ent", "<e2>", ",", "69", "with", "C0008677#ent", "<e2>", "without", "asthma", ")", "and", "30", "with", "both", "C0008677#ent", "<e2>", "C0004096#ent", "<e1>"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [7, 8]}}
{"token": ["394", "-", "406", ")", "of", "the", "VHL", "locus", ",", "truncating", "16", "amino", "acids", "C1413010#ent", "<e1>", "-", "77", ")", "from", "the", "first", "beta", "sheet", "the", "C0019562#ent", "<e2>"], "h": {"id": "C1413010", "name": "C1413010#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [24, 25]}}
{"token": ["Ten", "healthy", "volunteers", "12", "C0031485#ent", "<e1>", "PKU", ")", "heterozygotes", ",", "and", "5", "classic", "C0751434#ent", "<e2>", "have", "been", "loaded", "orally", "with", "a", "mixture", "of", "5", "microCi", "of", "L-[U-14C]phenylalanine", "plus", "25", "mg/kg", "of", "L-[2H5]phenylalanine", "."], "h": {"id": "C0031485", "name": "C0031485#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0751434", "name": "C0751434#ent", "pos": [13, 14]}}
{"token": ["The", "C0600327#ent", "<e1>", "similar", "in", "signs", ",", "but", "quite", "different", "in", "C2926735#ent", "<e2>", "."], "h": {"id": "C0600327", "name": "C0600327#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [11, 12]}}
{"token": ["The", "incidence", "of", "C0085083#ent", "<e1>", "does", "not", "increase", "with", "C0872894#ent", "<e2>", ",", "and", "a", "reduction", "can", "be", "expected", "with", "cetrorelix", "."], "h": {"id": "C0085083", "name": "C0085083#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0872894", "name": "C0872894#ent", "pos": [9, 10]}}
{"token": ["In", "newborn", "rats", ",", "the", "content", "of", "brain", "cytosol", "C1704945#ent", "<e1>", "(", "CuZnSOD", ")", "and", "mitochondrial", "SOD", "C1743497#ent", "<e2>", ")", "decreased", "after", "treatment", "with", "olive", "oil"], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [17, 18]}}
{"token": ["On", "the", "basis", "of", "these", "observations", ",", "C1704945#ent", "<e1>", "from", "Ba1", "was", "characterized", "as", "C1743497#ent", "<e2>", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [14, 15]}}
{"token": ["beta-Glucan", "was", "determined", "as", "the", "early", "diagnostic", "parameter", "of", "C0026946#ent", "<e1>", "and", "the", "relationships", "between", "the", "clinical", "efficacy", "C0025942#ent", "<e2>", "and", "the", "titers", "of", "beta-glucan", "were", "also", "evaluated", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [18, 19]}}
{"token": ["Despite", "the", "extensive", "C2917660#ent", "<e1>", "homology", "between", "gastrin", "and", "C1413167#ent", "<e2>", "(", "CCK", ")", "at", "the", "biologically", "active", "carboxyl", "terminus", "the", "receptors", "through", "which", "these", "peptides", "exert", "their", "action", "are", "heterogeneous", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413167", "name": "C1413167#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "ephedrine", "(", "C0812262#ent", "<e1>", ")", "were", "compared", "with", "those", "of", "C0026454#ent", "<e2>", "(", "Tyr", ")", "and", "phenylephrine", "(", "Phe", ")", "in", "ring", "segments", "guinea", "pig", "portal", "vein", "in", "vitro"], "h": {"id": "C0812262", "name": "C0812262#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [13, 14]}}
{"token": ["All", "patients", "(", "pts", ")", "were", "divided", "into", "two", "groups", ":", "Gr1", "included", "17", "pts", "with", "biopsy", "evidence", "of", "C0751039#ent", "<e1>", "damage", "and", "C1332034#ent", "<e2>", "-13", "pts", "without", "these", "changes", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1332034", "name": "C1332034#ent", "pos": [23, 24]}}
{"token": ["In", "this", "paper", "we", "report", "the", "construction", "of", "the", "linkage", "map", "HVT", "DNA", "for", "C0011513#ent", "<e1>", ",", "HindIII", ",", "and", "C0059209#ent", "<e2>"], "h": {"id": "C0011513", "name": "C0011513#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0059209", "name": "C0059209#ent", "pos": [20, 21]}}
{"token": ["To", "assess", "the", "efficacy", "of", "intracameral", "C0023660#ent", "<e1>", "supplementation", "of", "topical", "anesthesia", "cataract", "surgery", "eyes", "with", "C0271183#ent", "<e2>"], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0271183", "name": "C0271183#ent", "pos": [16, 17]}}
{"token": ["One", "of", "the", "interfering", "factors", "C0917805#ent", "<e1>", "is", "immune", "complex", "agglutinating", "immunoglobulin", "which", "reacts", "with", "a", "chemical", "component", "C0032483#ent", "<e2>", "reagent", "of", "the", "first", "reaction", "and", "causes", "remarkable", "turbidity", "in", "the", "initial", "phase", "."], "h": {"id": "C0917805", "name": "C0917805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [18, 19]}}
{"token": ["Since", "previous", "data", "demonstrate", "that", "C4277634#ent", "<e1>", "is", "a", "matrix", "metalloproteinase", "C0919336#ent", "<e2>", ")", "substrate", "and", "is", "highly", "unstable", "in", "conditioned", "medium", "eukaryotic", "cell", "types", "we", "created", "an", "insect", "cell", "line", "human", "C4277634#ent", "<e1>", "."], "h": {"id": "C4277634", "name": "C4277634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [11, 12]}}
{"token": ["First-line", "treatments", "C0733394#ent", "<e1>", "for", "orthostatic", "hypotension", "prokinetic", "drugs", "for", "C0152020#ent", "<e2>", ",", "broad-spectrum", "antibiotics", "for", "diabetic", "diarrhea", "and", "sildenafil", "for", "erectile", "dysfunction"], "h": {"id": "C0733394", "name": "C0733394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0152020", "name": "C0152020#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggested", "an", "involvement", "in", "C0065017#ent", "<e1>", "a", "mixed", "function", "oxidase", "system", "that", "for", "the", "C0038233#ent", "<e2>"], "h": {"id": "C0065017", "name": "C0065017#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038233", "name": "C0038233#ent", "pos": [16, 17]}}
{"token": ["As", "measured", "by", "immunochemical", "techniques", "the", "inhibition", "of", "the", "induction", "of", "these", "two", "enzyme", "systems", "from", "the", "decreased", "content", "of", "the", "C0065017#ent", "<e1>", "of", "the", "C0038233#ent", "<e2>", "the", "fatty", "acid", "synthetase"], "h": {"id": "C0065017", "name": "C0065017#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0038233", "name": "C0038233#ent", "pos": [25, 26]}}
{"token": ["The", "activity", "of", "delta", "9", "C0065017#ent", "<e1>", "decreased", "in", "alcohol-fed", "rats", "and", "C0038233#ent", "<e2>", "activity", "was", "similar", "in", "control", "and", "alcohol-fed", "groups", "."], "h": {"id": "C0065017", "name": "C0065017#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038233", "name": "C0038233#ent", "pos": [12, 13]}}
{"token": ["Hormonal", "conditions", "to", "mimic", "C0243026#ent", "<e1>", "were", "associated", "with", "increase", "in", "C1418372#ent", "<e2>", "expression.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418372", "name": "C1418372#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "we", "determined", "the", "effects", "of", "C0243026#ent", "<e1>", "on", "the", "steady-state", "level", "of", "C1418372#ent", "<e2>", "mRNA", "and", "on", "C1418372#ent", "<e2>", "activity", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418372", "name": "C1418372#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "was", "designed", "to", "test", "if", "C0031671#ent", "<e1>", "PLD", ")", "is", "regulated", "by", "C1413704#ent", "<e2>", "and", "if", "Rho-type", "small", "GTPases", "involved", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413704", "name": "C1413704#ent", "pos": [15, 16]}}
{"token": ["She", "may", "have", "developed", "alcoholic", "cirrhosis", "small", "amount", "of", "C0001962#ent", "<e1>", "because", "of", "common", "use", "of", "C0009905#ent", "<e2>", "drinking", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009905", "name": "C0009905#ent", "pos": [16, 17]}}
{"token": ["After", "allowing", "for", "these", "sex", "related", "differences", ",", "the", "effects", "of", "age", ",", "body", "size", "fasting", ",", "smoking", ",", "C0001962#ent", "<e1>", ",", "exercise", "and", "C0009905#ent", "<e2>", "usage", "on", "the", "parameters", "studied", "was", "defined", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0009905", "name": "C0009905#ent", "pos": [24, 25]}}
{"token": ["Consistent", "with", ",", "the", "N-terminal", "POZ", "domain", "required", "for", "cooperative", "binding", "of", "C1538149#ent", "<e1>", "to", "a", "multimerized", "C1867727#ent", "<e2>", "."], "h": {"id": "C1538149", "name": "C1538149#ent", "pos": [12, 13]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1867727", "name": "C1867727#ent", "pos": [17, 18]}}
{"token": ["The", "relationship", "of", "prostaglandin", "(", "PG", ")", "release", "to", "changes", "in", "renin", "release", "and", "renal", "blood", "flow", "RBF", ")", "to", "renal", "nerve", "stimulation", "C1850106#ent", "<e1>", ")", "was", "investigated", "in", "C0700349#ent", "<e2>", "anesthetized", "dogs", "."], "h": {"id": "C1850106", "name": "C1850106#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0700349", "name": "C0700349#ent", "pos": [29, 30]}}
{"token": ["These", "included", "10", "healthy", "controls", "10", "controls", "with", "C0476281#ent", "<e1>", "and", "three", "groups", "of", "10", "patients", "each", "with", "C0340288#ent", "<e2>", "unstable", "angina", "rest", ",", "or", "acute", "myocardial", "infarction"], "h": {"id": "C0476281", "name": "C0476281#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [18, 19]}}
{"token": ["Lipoxygenase", "catalyzes", "the", "oxidation", "of", "C0394006#ent", "<e1>", "to", "its", "corresponding", "C0394006#ent", "<e1>", "quinone", "to", "yield", "free", "radical", "species", "intermediates", "(", "C0394006#ent", "<e1>", "semiquinone", "and", "DES", "quinone", ",", "which", "are", "associated", "with", "adverse", "effects", "this", "C0003805#ent", "<e1>"], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [34, 35]}}
{"token": ["Diethylstilbestrol", "(", "C0394006#ent", "<e1>", ")", "is", "a", "C0003805#ent", "<e2>", "carcinogenic", "properties", "."], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [7, 8]}}
{"token": ["Is", "this", "role", "of", "C0079471#ent", "<e1>", "restricted", "to", "C1416660#ent", "<e2>", ",", "or", "does", "C0079471#ent", "<e1>", "represent", "a", "nodal", "point", "for", "signals", "from", "multiple", "other", "factors", "with", "opposing", "functions", "in", "cancer", "?"], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416660", "name": "C1416660#ent", "pos": [8, 9]}}
{"token": ["We", "report", "here", "for", "the", "first", "time", "that", "both", "Shh", "and", "C0342384#ent", "<e1>", "mRNA", "are", "expressed", "in", "the", "C1705010#ent", "<e2>", "of", "rapidly", "growing", "6-week-old", "broiler-strain", "chickens"], "h": {"id": "C0342384", "name": "C0342384#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705010", "name": "C1705010#ent", "pos": [18, 19]}}
{"token": ["The", "main", "result", "was", "significantly", "lower", "pressure", "pain", "detection", "thresholds", "and", "tolerances", "in", "all", "the", "examined", "locations", "in", "patients", "with", "C0393738#ent", "<e1>", "a", "C0752352#ent", "<e2>", "to", "those", "without", "a", "C0752352#ent", "<e2>"], "h": {"id": "C0393738", "name": "C0393738#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0752352", "name": "C0752352#ent", "pos": [23, 24]}}
{"token": ["We", "report", "that", "activation", "of", "adenosine", "receptors", "adenosine", "analogs", ",", "or", "activation", "of", "the", "putative", "C1334908#ent", "<e1>", "the", "G", "protein-coupled", "receptor", "adenosine", "A2b", "receptor", "A2bR", ")", "results", "in", "PKCalpha-dependent", "removal", "of", "C1421357#ent", "<e2>", "from", "the", "cell", "surface"], "h": {"id": "C1334908", "name": "C1334908#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1421357", "name": "C1421357#ent", "pos": [31, 32]}}
{"token": ["We", "detected", "the", "expression", "of", "C1334908#ent", "<e1>", "Sema3a", "in", "the", "optic", "chiasma", "and", "that", "of", "C1421357#ent", "<e2>", "and", "neuropilin", "1", "the", "optic", "nerve"], "h": {"id": "C1334908", "name": "C1334908#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421357", "name": "C1421357#ent", "pos": [15, 16]}}
{"token": ["At", "present", ",", "the", "standard", "therapy", "C0013595#ent", "<e1>", "a", "topical", "steroid", "a", "topical", "immunomodulator", "an", "emollient", "and", "an", "C0019592#ent", "<e2>", "although", "few", "studies", "have", "reported", "the", "effect", "of", "this", "treatment", "regimen", "QOL", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019592", "name": "C0019592#ent", "pos": [18, 19]}}
{"token": ["Finally", ",", "evidence", "is", "provided", "that", "corticosteroids", "suppress", "neurogenic", "plasma", "extravasation", "and", "that", "this", "C1254351#ent", "<e1>", "can", "upregulate", "C3887624#ent", "<e2>", "in", "human", "airway", "tissue"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [18, 19]}}
{"token": ["Captopril", ",", "a", "C1254351#ent", "<e1>", "able", "to", "potentiate", "morphine", "analgesia", "in", "rats", "and", "inhibit", "C3887624#ent", "<e2>", "in", "animals", "and", "in", "man", ",", "improves", "the", "clinical", "course", "migraine", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [14, 15]}}
{"token": ["We", "designed", "a", "C0019069#ent", "<e1>", "involving", "the", "genetic", "modification", "haematopoietic", "stem", "cells", "achieve", "tissue-specific", "expression", "a", "factor", "VIII", "C2732002#ent", "<e2>", ")", "transgene", "in", "the", "megakaryocytic", "lineage"], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C2732002", "name": "C2732002#ent", "pos": [18, 19]}}
{"token": ["In", "recent", "years", "the", "treatment", "of", "patients", "with", "C0019069#ent", "<e1>", "B", "has", "been", "intravenous", "injection", "of", "C2732002#ent", "<e2>", "or", "FIX", "concentrates", ",", "respectively", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C2732002", "name": "C2732002#ent", "pos": [16, 17]}}
{"token": ["Conventional", "gene", "therapy", "C0019069#ent", "<e1>", "A", "relies", "on", "the", "transfer", "of", "factor", "VIII", "C2732002#ent", "<e2>", ";", "encoded", "by", "the", "F8", "gene", "cDNA", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C2732002", "name": "C2732002#ent", "pos": [13, 14]}}
{"token": ["Several", "proteins", "related", "to", "stress", "response", "C0017837#ent", "<e1>", "catalase", ",", "and", "C3539602#ent", "<e2>", "and", "basic", "metabolism", "(", "glyceraldehyde-3-phosphate", "dehydrogenase", "dihydroxy-acid", "dehydratase", "and", "arginase", ")", "were", "identified", "in", "the", "cellular", "proteome"], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539602", "name": "C3539602#ent", "pos": [11, 12]}}
{"token": ["Hence", ",", "the", "EP2", "C0243192#ent", "<e1>", "may", "be", "a", "potent", "therapeutic", "agent", "C0007302#ent", "<e2>"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007302", "name": "C0007302#ent", "pos": [12, 13]}}
{"token": ["Secondary", "symptomatic", "C0036396#ent", "<e1>", "may", "by", "caused", "by", "metastases", "to", "the", "vertebra", ",", "C0041296#ent", "<e2>", "of", "the", "spine", ",", "tumors", "located", "inside", "the", "vertebral", "channel", "or", "entrapment", "of", "the", "sciatic", "nerve", "the", "piriformis", "muscle"], "h": {"id": "C0036396", "name": "C0036396#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [13, 14]}}
{"token": ["We", "suggest", "that", "the", "C4255122#ent", "<e1>", "chondrocytes", "to", "IL-1", "and", "C0003873#ent", "<e2>", "is", "dependent", "on", "the", "activity", "of", "a", "GPI-anchored", "protein", "the", "chondrocyte", "cell", "surface", "."], "h": {"id": "C4255122", "name": "C4255122#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}}
{"token": ["The", "absence", "of", "WT1", "mutations", "tumours", "with", "C1334091#ent", "<e1>", "LOI", "indicated", "that", "C1332803#ent", "<e2>", "mutations", "occur", "predominantly", "in", "tumours", "arising", "from", "ILNR", "independent", "of", "the", "presence", "or", "absence", "of", "WT1", "mutations"], "h": {"id": "C1334091", "name": "C1334091#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [12, 13]}}
{"token": ["In", "C1420728#ent", "<e1>", "GN", ",", "phosphorylated", "C1367307#ent", "<e2>", "in", "glomerular", "MC", "at", "day", "6", "and", "correlated", "with", "MC", "expansion", "."], "h": {"id": "C1420728", "name": "C1420728#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [6, 7]}}
{"token": ["Ultraviolet", "irradiation", "malignant", "melanoma", "benign", "tumors", "the", "RET-transgenic", "mice", "line", "192", ",", "and", "promoted", "C1421249#ent", "<e1>", "Erk", "and", "C1623430#ent", "<e2>"], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [18, 19]}}
{"token": ["We", "found", "that", "the", "activities", "of", "C1421249#ent", "<e1>", "Erk", "and", "C1623430#ent", "<e2>", "are", "definitely", "upregulated", "in", "malignant", "melanoma", "the", "RET-transgenic", "mice", "line", "304/B6", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [10, 11]}}
{"token": ["Restraint", "and", "isolation", "stress", "clear", "increases", "in", "plasma", "concentrations", "of", "C1704793#ent", "<e1>", ",", "cortisol", ",", "lactate", ",", "and", "C0004002#ent", "<e2>", "had", "minimal", "effects", "on", "serum", "electrolytes"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004002", "name": "C0004002#ent", "pos": [18, 19]}}
{"token": ["On", "the", "other", "hand", ",", "the", "formation", "of", "reductive", "metabolite", "C0078844#ent", "<e1>", "was", "the", "highest", "in", "COS-7", "cells", "expressing", "C1176140#ent", "<e2>", ",", "followed", "by", "CYP3A7", "and", "CYP3A5", "."], "h": {"id": "C0078844", "name": "C0078844#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [19, 20]}}
{"token": ["A", "three-state", "model", "with", "one", "dark", "and", "two", "fluorescent", "states", "the", "power-dependence", "of", "the", "C0085635#ent", "<e1>", "dynamics", "of", "both", "C0086376#ent", "<e2>", "at", "different", "excitation", "wavelengths"], "h": {"id": "C0085635", "name": "C0085635#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "we", "show", "that", "the", "C0085635#ent", "<e1>", "in", "these", "C0086376#ent", "<e2>", "is", "pH-dependent", "."], "h": {"id": "C0085635", "name": "C0085635#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["The", "picture", "is", "based", "on", "the", "recently", "published", "model", "liquid", "structure", "which", "proposes", "that", "clusters", "in", "water", "have", "long-term", "rather", "than", "C0085635#ent", "<e1>", "existence", "and", "are", "as", "large", "as", "C0086376#ent", "<e2>", "."], "h": {"id": "C0085635", "name": "C0085635#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [29, 30]}}
{"token": ["Smaller", "studies", "used", "similar", "target", "doses", ",", "but", "a", "beneficial", "effect", "on", "C0149721#ent", "<e1>", "been", "shown", "with", "a", "daily", "dose", "only", "75", "mg", "C0006938#ent", "<e2>", "."], "h": {"id": "C0149721", "name": "C0149721#ent", "pos": [12, 13]}, "relation": "may_be_prevented_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [23, 24]}}
{"token": ["Peptide", "blotting", "using", "a", "series", "of", "designed", "C0030956#ent", "<e1>", "with", "profilins", "1", "2a", "indicates", "differences", "between", "the", "two", "C1456390#ent", "<e2>", "towards", "proline-rich", "peptides", "from", "mDia1", "and", "VASP", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1456390", "name": "C1456390#ent", "pos": [18, 19]}}
{"token": ["In", "the", "three", "peptide", "probes", "the", "C0030956#ent", "<e1>", "the", "highest", "affinity", "to", "C1456390#ent", "<e2>", ",", "i.e.", ",", "sequence", "dependent", "affinity", "was", "confirmed", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1456390", "name": "C1456390#ent", "pos": [12, 13]}}
{"token": ["We", "have", "designed", "and", "synthesized", "three", "different", "peptide", "probes", "H-Ala3-(Gly-Pro5)3-Gly-OH", "(", "peptide", "A", ",", "H-Ala3-(Gly-Pro5)-Gly-OH", "(", "C0030956#ent", "<e1>", "and", "H-Ala3-Gly-OH", "(", "peptide", "C", "for", "testing", "their", "affinities", "to", "C1456390#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1456390", "name": "C1456390#ent", "pos": [28, 29]}}
{"token": ["Findings", "revealed", "that", "all", "study", "participants", "had", "3", "or", "more", "risk", "factors", "placing", "them", "in", "the", "moderate", "risk", "category", "for", "C0018799#ent", "<e1>", "having", "a", "C0155668#ent", "<e2>", "10", "years", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0155668", "name": "C0155668#ent", "pos": [24, 25]}}
{"token": ["This", "context-specific", "activity", "may", "contribute", "to", "its", "enhanced", "C0020615#ent", "<e1>", "potency", "in", "vivo", "reduced", "affinity", "for", "C1335238#ent", "<e2>", "[", "335218", "]", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [16, 17]}}
{"token": ["These", "results", "indicate", "that", "licorice", "hydrophobic", "flavonoids", "have", "abdominal", "fat-lowering", "and", "C0020615#ent", "<e1>", "effects", ",", "possibly", "mediated", "via", "activation", "of", "C1335238#ent", "<e2>", "PPAR-gamma", ")", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [20, 21]}}
{"token": ["Until", "now", ",", "there", "has", "been", "an", "excellent", "correlation", "between", "in", "vivo", "C0020615#ent", "<e1>", "potency", "and", "in", "vitro", "binding", "and", "activation", "of", "C1335238#ent", "<e2>", "by", "TZDs", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [22, 23]}}
{"token": ["C3541254#ent", "<e1>", "specifically", "expressed", "on", "Th1", "cells", "negatively", "regulates", "C3540579#ent", "<e2>", "responses", ",", "whereas", "Tim-2", "is", "preferentially", "expressed", "in", "Th2", "cells"], "h": {"id": "C3541254", "name": "C3541254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [9, 10]}}
{"token": ["HASS", "was", "adapted", "to", "meet", "changing", "surveillance", "needs", "(", "e.g.", ",", "surveillance", "for", "C0003175#ent", "<e1>", ",", "smallpox", ",", "and", "severe", "C1175175#ent", "<e2>", "."], "h": {"id": "C0003175", "name": "C0003175#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1175175", "name": "C1175175#ent", "pos": [20, 21]}}
{"token": ["In", "man", ",", "this", "C0014442#ent", "<e1>", "is", "encoded", "by", "the", "C1706115#ent", "<e2>", "(", "CYP21B", ")", "gene", "which", "is", "located", "in", "the", "HLA", "major", "histocompatibility", "complex", "with", "a", "pseudogene", ",", "CYP21P", "(", "CYP21A", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706115", "name": "C1706115#ent", "pos": [10, 11]}}
{"token": ["This", "study", "suggests", "that", "Caucasians", "bearing", "an", "APOE2", "C1706112#ent", "<e1>", "are", "at", "increased", "risk", "of", "developing", "C0686347#ent", "<e2>", "whereas", "African-Americans", "are", "not", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0686347", "name": "C0686347#ent", "pos": [16, 17]}}
{"token": ["It", "will", "review", "the", "pathogenesis", "of", "C0031099#ent", "<e1>", "and", "the", "mechanisms", "by", "which", "C0747479#ent", "<e2>", "affect", "the", "onset", "and", "progression", "of", "AD", "."], "h": {"id": "C0031099", "name": "C0031099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0747479", "name": "C0747479#ent", "pos": [13, 14]}}
{"token": ["We", "demonstrate", "the", "use", "of", "a", "novel", "subtractive", "cDNA", "cloning", "approach", "the", "isolation", "and", "characterization", "of", "target", "C0017337#ent", "<e1>", "of", "the", "C3641847#ent", "<e2>", "EBNA2", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3641847", "name": "C3641847#ent", "pos": [21, 22]}}
{"token": ["All", "evidence", "supported", "the", "concept", "that", "in", "human", "cells", "active", "MeCbl", "on", "C0026269#ent", "<e1>", "forms", "de", "novo", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [18, 19]}}
{"token": ["Here", "we", "report", "results", "of", "N-terminal", "sequencing", "C0026269#ent", "<e1>", "carried", "out", "with", "the", "A", "C0014442#ent", "<e2>", ",", "which", "establish", "that", "the", "latter", "contains", "rpo", "gene", "products", "and", "is", "structurally", "related", "to", "the", "B", "enzyme"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["UV", ",", "NMR", ",", "and", "C0026269#ent", "<e1>", "data", "prove", "that", "the", "C0014442#ent", "<e2>", "catalyzes", "the", "elimination", "of", "triphosphate", "as", "well", "as", "the", "intramolecular", "rearrangement"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "C0060441#ent", "<e1>", "inhibited", "the", "activity", "of", "the", "intracellular", "enzyme", ",", "C1417932#ent", "<e2>", "ODC", ")", ",", "in", "stimulated", "PBL", "and", "LPL", "."], "h": {"id": "C0060441", "name": "C0060441#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [13, 14]}}
{"token": ["GIN14", ",", "a", "mouse", "monoclonal", "antibody", "HTLV", "core", "protein", "C4049865#ent", "<e1>", ")", "detected", "not", "only", "C4049865#ent", "<e1>", "in", "various", "cell", "lines", "also", "C1422587#ent", "<e1>", ",", "p29", ",", "p31", "or", "p40", "in", "certain", "cell", "lines", "tested", "."], "h": {"id": "C4049865", "name": "C4049865#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422587", "name": "C1422587#ent", "pos": [22, 23]}}
{"token": ["After", "incubating", "C3889380#ent", "<e1>", "erythrocytes", "(", "PNH-E", ")", "with", "purified", "C3272448#ent", "<e2>", ",", "the", "cells", "were", "analyzed", "by", "flow", "cytometry", "a", "monoclonal", "antibody", "C3272448#ent", "<e2>", "and", "shown", "to", "have", "the", "antigen", "absorbed", "."], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3272448", "name": "C3272448#ent", "pos": [10, 11]}}
{"token": ["The", "deletion", "C2712370#ent", "<e1>", "the", "substrate", "binding", "pocket", "by", "moving", "C1706319#ent", "<e2>", ",", "which", "sterically", "hinders", "binding", "of", "steroids", "in", "the", "E", "isoenzyme"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706319", "name": "C1706319#ent", "pos": [10, 11]}}
{"token": ["In", "syndromic", "cases-mitochondrial", "encephalopathy", "lactic", "acidosis", "and", "strokelike", "episodes", "MELAS", ")", ",", "maternally", "inherited", "C0011849#ent", "<e1>", "and", "deafness", ",", "C0022541#ent", "<e2>", "and", "chronic", "progressive", "ophthalmoplegia-the", "SNHL", "compounds", "already", "existing", "disabilities", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0022541", "name": "C0022541#ent", "pos": [19, 20]}}
{"token": ["Bak", "wt", "or", "Bak", "deltaBH3", "were", "also", "able", "to", "abrogate", "the", "protective", "effect", "C0376515#ent", "<e1>", "in", "cells", "expressing", "C0376515#ent", "<e1>", "and", "Bak", "wt", "or", "Bak", "deltaBH3", "when", "challenged", "by", "C0015133#ent", "<e1>", "or", "fluorouracil", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [29, 30]}}
{"token": ["However", ",", "ECM", "prevented", "p21", "and", "C0376515#ent", "<e1>", "down-regulation", "induced", "by", "taxol", "or", "C0015133#ent", "<e2>", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [13, 14]}}
{"token": ["C0376515#ent", "<e1>", "overexpression", "abrogated", "the", "Cer", "response", "C0015133#ent", "<e2>", "and", "IR", "and", "reduced", "CD95-induced", "Cer", "accumulation", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [7, 8]}}
{"token": ["We", "investigated", "the", "T", "cell", "receptor", "constant", "beta", "chain", "C0524891#ent", "<e1>", "patients", "with", "insulin", "dependent", "diabetes", "mellitus", "C0011854#ent", "<e2>", ")", "using", "DNA", "restriction", "fragment", "length", "polymorphism", "RFLP", ")", "analysis", "."], "h": {"id": "C0524891", "name": "C0524891#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [17, 18]}}
{"token": ["It", "combines", "potent", ",", "selective", ",", "and", "reversible", "inhibition", "of", "C0026456#ent", "<e1>", "with", "blockade", "of", "voltage-dependent", "Na+", "and", "C1413043#ent", "<e2>", "+", "channels", "and", "inhibition", "of", "glutamate", "release", "."], "h": {"id": "C0026456", "name": "C0026456#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "irradiated", "cells", "C1705526#ent", "<e1>", "89", "%", "inhibition", "of", "cell", "death", "C0672005#ent", "<e2>", "and", "98", "%", "inhibition", "with", "the", "antioxidant", "N-acetyl-L-cysteine", "NAC", ")", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0672005", "name": "C0672005#ent", "pos": [13, 14]}}
{"token": ["One", "of", "the", "histologic", "hallmarks", "of", "C1704852#ent", "<e1>", "is", "interstitial", "fibrosis", "influenced", "by", "C0623362#ent", "<e2>", "MMPs", ")", "that", "are", "controlling", "extracellular", "matrix", "ECM", ")", "degradation", "."], "h": {"id": "C1704852", "name": "C1704852#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [13, 14]}}
{"token": ["One", "of", "the", "histologic", "hallmarks", "of", "C1704852#ent", "<e1>", "is", "interstitial", "fibrosis", "influenced", "by", "matrix", "metalloproteinases", "C0623362#ent", "<e2>", ")", "that", "are", "controlling", "extracellular", "matrix", "ECM", ")", "degradation", "."], "h": {"id": "C1704852", "name": "C1704852#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [15, 16]}}
{"token": ["The", "results", "of", "this", "study", "suggest", "that", "the", "forms", "of", "DNA", "polymerase", "Drosophila", "embryos", "have", "physical", "properties", "to", "those", "of", "C0012888#ent", "<e1>", "enzymatic", "properties", "similar", "to", "those", "of", "all", "three", "C0012892#ent", "<e2>"], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [20, 21]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [30, 31]}}
{"token": ["We", "report", "the", "identification", "of", "a", "human", "C1334043#ent", "<e1>", "of", "the", "vesicle-associated", "membrane", "protein", "(VAMP)-associated", "protein", "C1421424#ent", "<e2>", ")", "that", "has", "been", "implicated", "in", "neuronal", "exocytosis", "Aplysia", "californica"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421424", "name": "C1421424#ent", "pos": [16, 17]}}
{"token": ["We", "find", "that", "cER", "inheritance", "is", "defective", "in", "cells", "lacking", "Scs2", ",", "a", "C1334043#ent", "<e1>", "the", "integral", "ER", "membrane", "protein", "VAP", "C1421424#ent", "<e2>", "conserved", "in", "all", "eukaryotes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1421424", "name": "C1421424#ent", "pos": [21, 22]}}
{"token": ["C3669212#ent", "<e1>", "increased", "with", "halothane", "but", "decreased", "with", "C0014277#ent", "<e2>", "."], "h": {"id": "C3669212", "name": "C3669212#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014277", "name": "C0014277#ent", "pos": [8, 9]}}
{"token": ["In", "the", "non", "zinc-deficient", "group", "of", "pregnant", "females", "C0061078#ent", "<e1>", "supplementation", "had", "no", "effect", "fatty", "acid", "synthetase", "delta", "9-desaturase", "activities", "but", "significantly", "increased", "C2975999#ent", "<e2>", "."], "h": {"id": "C0061078", "name": "C0061078#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2975999", "name": "C2975999#ent", "pos": [23, 24]}}
{"token": ["The", "results", "establish", "the", "target", "for", "the", "alloantibodies", "from", "an", "autosomal", "recessive", "C1567741#ent", "<e1>", "patient", "with", "C1704812#ent", "<e2>", "principally", "the", "alpha", "3(IV)", "collagen", "chain", "similar", "to", "the", "post-transplant", "alloantibodies", "X-linked", "Alport", "patients", "with", "COL4A5", "gene", "deletions"], "h": {"id": "C1567741", "name": "C1567741#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1704812", "name": "C1704812#ent", "pos": [16, 17]}}
{"token": ["The", "autosomal", "recessive", "form", "C1567741#ent", "<e1>", "characterized", "by", "mutations", "and", "deletions", "in", "the", "C1704812#ent", "<e2>", "and", "COL4A4", "genes"], "h": {"id": "C1567741", "name": "C1567741#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1704812", "name": "C1704812#ent", "pos": [13, 14]}}
{"token": ["C0006864#ent", "<e1>", ",", "including", "the", "endogenous", "C3536852#ent", "<e2>", "or", "endocannabinoid", ",", "anandamide", ",", "modulate", "several", "gastrointestinal", "functions"], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C3536852", "name": "C3536852#ent", "pos": [6, 7]}}
{"token": ["The", "present", "data", "provide", "the", "first", "evidence", "that", "the", "endocannabinoid", "AEA", "and", "different", "synthetic", "C0006864#ent", "<e1>", "may", "inhibit", "the", "P-gp", "activity", "in", "vitro", "a", "C3536852#ent", "<e2>", "receptor-independent", "mechanism", "."], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [14, 15]}, "relation": "chemical_structure_of", "t": {"id": "C3536852", "name": "C3536852#ent", "pos": [24, 25]}}
{"token": ["Among", "the", "examined", "group", ",", "the", "most", "frequently", "occurring", "C0009450#ent", "<e1>", "infections", "of", "the", "ureter", ",", "bronchitis", ",", "C3811318#ent", "<e2>", "and", "ear", "infection"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811318", "name": "C3811318#ent", "pos": [18, 19]}}
{"token": ["It", "was", "considered", "that", "C1412302#ent", "<e1>", "could", "be", "one", "of", "the", "C0034087#ent", "<e2>", "MPA", "."], "h": {"id": "C1412302", "name": "C1412302#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034087", "name": "C0034087#ent", "pos": [11, 12]}}
{"token": ["This", "was", "followed", "by", "a", "reduction", "of", "C0079068#ent", "<e1>", "mRNA", "and", "an", "increase", "of", "C0010803#ent", "<e2>", "mRNA", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [14, 15]}}
{"token": ["It", "has", "been", "widely", "speculated", "that", "this", "C0027877#ent", "<e1>", "deposition", "is", "related", "to", "C0042875#ent", "<e2>"], "h": {"id": "C0027877", "name": "C0027877#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042875", "name": "C0042875#ent", "pos": [13, 14]}}
{"token": ["C0027877#ent", "<e1>", "accumulation", "in", "the", "mesenteric", "lymph", "node", "not", "depend", "on", "C0042875#ent", "<e2>"], "h": {"id": "C0027877", "name": "C0027877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042875", "name": "C0042875#ent", "pos": [11, 12]}}
{"token": ["The", "mnd", "mouse", ",", "a", "model", "of", "C0027877#ent", "<e1>", "NCL", ")", ",", "has", "a", "profound", "C0042875#ent", "<e2>", "sera", "and", "brain", ",", "associated", "with", "cerebral", "deterioration", "of", "NCL", "."], "h": {"id": "C0027877", "name": "C0027877#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042875", "name": "C0042875#ent", "pos": [15, 16]}}
{"token": ["While", "some", "cyanobacterial", "toxins", "as", "C1720911#ent", "<e1>", "been", "investigated", "extensively", ",", "other", "C1136365#ent", "<e2>", "cyanobacteria", "(", "e.g.", "lipopolysaccharides", ",", "LPS", ")", "are", "poorly", "understood", "."], "h": {"id": "C1720911", "name": "C1720911#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [12, 13]}}
{"token": ["The", "positive", "effect", "of", "valsartan/amlodipine", "combination", "on", "C0004238#ent", "<e1>", "recurrence", "was", "more", "evident", "in", "patients", "treated", "with", "amiodarone", "or", "C0700465#ent", "<e2>", "than", "in", "patients", "treated", "with", "antiarrhythmic", "drugs", "without", "antiarrhythmic", "treatment", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0700465", "name": "C0700465#ent", "pos": [19, 20]}}
{"token": ["A", "population", "of", "123", "patients", "with", "recent-onset", "(", "<", "72", "hours", ")", "atrial", "fibrillation", "C0004238#ent", "<e1>", ")", "without", "heart", "failure", "randomly", "treated", "with", "C0700465#ent", "<e2>", "(", "PFN", ")", "intravenously", "(", "i.v", ".", ")", "("], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0700465", "name": "C0700465#ent", "pos": [23, 24]}}
{"token": ["A", "variety", "of", "drugs", "effective", "against", "clinical", "C0004238#ent", "<e1>", ",", "including", "flecainide", ",", "C0700465#ent", "<e2>", ",", "procainamide", ",", "and", "sotalol", ",", "have", "been", "found", "to", "terminate", "experimental", "C0004238#ent", "<e1>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0700465", "name": "C0700465#ent", "pos": [13, 14]}}
{"token": ["Neuronal", "loss", "more", "marked", "in", "X-BSMA", "than", "in", "C1862939#ent", "<e1>", "ALS", ")", "and", "C0037019#ent", "<e2>", "SDS", ")", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [13, 14]}}
{"token": ["Autonomic", "function", "cardiovascular", "regulation", "evaluated", "in", "C1862939#ent", "<e1>", "ALS", ")", "in", "comparison", "with", "C0037019#ent", "<e2>"], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [13, 14]}}
{"token": ["Electromyography", "(", "EMG", ")", "of", "anal", "sphincter", "muscles", "was", "different", "in", "patients", "with", "C1862939#ent", "<e1>", "ALS", ")", "and", "C0037019#ent", "<e2>"], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [18, 19]}}
{"token": ["The", "C0340861#ent", "<e1>", "value", "of", "C0058031#ent", "<e2>", "ranged", "from", "8.6", "x", "10(-4", ")", "to", "37.5", "x", "10(-4", ")", "mL", "min(-1", ")", "g(-1", ")", "in", "different", "brain", "regions"], "h": {"id": "C0340861", "name": "C0340861#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058031", "name": "C0058031#ent", "pos": [5, 6]}}
{"token": ["C0812258#ent", "<e1>", "can", "signal", "p53", "phosphorylation", "in", "the", "absence", "of", "C0525037#ent", "<e2>", ",", "similar", "to", "the", "observed", "modifications", "to", "p53", "in", "response", "to", "DNA", "damage"], "h": {"id": "C0812258", "name": "C0812258#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [10, 11]}}
{"token": ["p19ARF-induced", "degradation", "of", "C0812258#ent", "<e1>", "depended", "on", "a", "functional", "proteasome", ",", "and", "C0812258#ent", "<e1>", "was", "relocalized", "to", "nucleoli", "when", "coexpressed", "with", "C0525037#ent", "<e1>", "."], "h": {"id": "C0812258", "name": "C0812258#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [21, 22]}}
{"token": ["Cathepsin", "D", "catD", ")", "is", "an", "intracellular", "C0078989#ent", "<e1>", "exhibits", "beta", "and", "gamma", "secretase-like", "activity", "to", "cleave", "amyloid", "precursor", "protein", "C0078939#ent", "<e2>"], "h": {"id": "C0078989", "name": "C0078989#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [20, 21]}}
{"token": ["Human", "beta-amyloid", "precursor", "protein", "cleaving", "enzyme", "beta-secretase", ",", "or", "BACE", ")", "belongs", "to", "the", "C0078989#ent", "<e1>", "and", "is", "responsible", "for", "generating", "the", "N-terminus", "of", "C0078939#ent", "<e2>", "Abeta", ")", "."], "h": {"id": "C0078989", "name": "C0078989#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [24, 25]}}
{"token": ["Several", "other", "agents", "are", "commonly", "used", "to", "prevent", "C0149931#ent", "<e1>", "attacks", "in", "children", "(", "e.g.", "amitriptyline", ",", "C0042291#ent", "<e2>", "sodium", "valproate", ")", "despite", "a", "lack", "of", "robust", "research", "into", "their", "efficacy", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [17, 18]}}
{"token": ["Three", "patients", "responded", "to", "preventive", "treatment", "C0149931#ent", "<e1>", "with", "beta-blockers", "(", "n", "=", "2", ")", "or", "C0042291#ent", "<e2>", "n", "=", "1", ")", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [16, 17]}}
{"token": ["His", "C0149931#ent", "<e1>", "responded", "well", "to", "pizotifen", ",", "and", "both", "C0149931#ent", "<e1>", "and", "Raynaud", "phenomenon", "improved", "after", "initiation", "of", "treatment", "with", "C0042291#ent", "<e1>"], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [1, 2]}, "relation": "may_be_prevented_by", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [21, 22]}}
{"token": ["C0039052#ent", "<e1>", "useful", "in", "the", "treatment", "of", "patients", "with", "C0151744#ent", "<e2>", "by", "heart", "failure", "shock", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [9, 10]}}
{"token": ["Cocaine", "is", "a", "C0039052#ent", "<e1>", "can", "cause", "coronary", "artery", "vasospasm", "to", "C0151744#ent", "<e2>", "acute", "coronary", "syndrome", "acute", "myocardial", "infarction", "ACS/AMI", ")", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [11, 12]}}
{"token": ["The", "left", "ventricular", "sensitivity", "C0039052#ent", "<e1>", "assessed", "in", "47", "patients", "with", "C0151744#ent", "<e2>", "varying", "degrees", "of", "left", "ventricular", "dysfunction"], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [11, 12]}}
{"token": ["The", "homozygous", "deletions", "affected", "a", "number", "of", "biologically", "important", "C0017337#ent", "<e1>", ",", "including", "PPP2R2A", "and", "C1332435#ent", "<e2>", "identified", "in", "this", "study", "and", "CDKN2A/CDKN2B", "reported", "previously", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332435", "name": "C1332435#ent", "pos": [15, 16]}}
{"token": ["Previously", "uncharacterized", "conserved", "domains", "involved", "in", "repair", "were", "identified", ",", "namely", "four", "families", "of", "C0597094#ent", "<e1>", "and", "a", "family", "of", "eukaryotic", "repair", "proteins", "to", "the", "C1366837#ent", "<e2>"], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [25, 26]}}
{"token": ["Alterations", "of", "membrane", "surface", "membrane", "microviscosity", "were", "studied", "in", "peripheral", "blood", "lymphocytes", "C0947912#ent", "<e1>", "patients", "and", "compared", "with", "those", "from", "healthy", "subjects", "C0024141#ent", "<e2>", "patients", "."], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [22, 23]}}
{"token": ["Thymectomy", "in", "C0947912#ent", "<e1>", "patients", "may", "be", "associated", "with", "emergence", "of", "new", "autoimmune", "conditions", "as", "C0024141#ent", "<e2>", "and", "APS", ",", "pointing", "to", "the", "importance", "of", "immune", "dysregulation", "the", "induction", "of", "these", "autoimmune", "diseases"], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [15, 16]}}
{"token": ["Under", "propranolol", "pretreatment", "conditions", ",", "C0132531#ent", "<e1>", "no", "longer", "affected", "the", "heart", "rate", "but", "the", "C0013227#ent", "<e2>", "still", "induced", "a", "transient", "reduction", "in", "peripheral", "vascular", "resistance", "and", "sustained", "decreases", "in", "arterial", "blood", "pressure", "cardiac", "output"], "h": {"id": "C0132531", "name": "C0132531#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [15, 16]}}
{"token": ["The", "rate", "of", "C0072196#ent", "<e1>", "formation", "was", "not", "affected", "by", "C0376286#ent", "<e2>"], "h": {"id": "C0072196", "name": "C0072196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0376286", "name": "C0376286#ent", "pos": [10, 11]}}
{"token": ["Using", "a", "ChIP", "assay", "we", "showed", "rapid", "induction", "of", "acetylation", "of", "the", "histones", "H3", "C1425774#ent", "<e1>", "which", "interacted", "with", "the", "promoter/enhancer", "region", "of", "the", "CRBPII", "C0079429#ent", "<e2>", "at", "this", "time", "."], "h": {"id": "C1425774", "name": "C1425774#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [25, 26]}}
{"token": ["Of", "the", "C0012634#ent", "<e1>", "these", "are", "C1849508#ent", "<e2>", "GABA", "transaminase", "deficiency", "and", "succinic", "semialdehyde", "dehydrogenase", "deficiency"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1849508", "name": "C1849508#ent", "pos": [6, 7]}}
{"token": ["We", "previously", "found", "that", "C1415846#ent", "<e1>", "synergizes", "with", "TCR", "and", "C1332709#ent", "<e2>", "to", "greatly", "enhance", "NFATc1", "expression", "in", "primary", "T", "cells"], "h": {"id": "C1415846", "name": "C1415846#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332709", "name": "C1332709#ent", "pos": [10, 11]}}
{"token": ["However", ",", "C1415846#ent", "<e1>", "costimulation", "shows", "greater", "PI3", "K", "activity", "than", "C1332709#ent", "<e2>", "in", "T", "cells"], "h": {"id": "C1415846", "name": "C1415846#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332709", "name": "C1332709#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "are", "presenting", "a", "selective", "extraction", "method", "for", "typical", "well-characterized", "mammalian", "GPI-proteins", ",", "e.g.", ",", "acetylcholine", "esterase", "alkaline", "phosphatase", "5'-nucleotidase", ",", "and", "C0023816#ent", "<e1>", "using", "a", "derivative", "of", "C2827312#ent", "<e2>", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2827312", "name": "C2827312#ent", "pos": [29, 30]}}
{"token": ["Five", "alleles", "of", "the", "C1504688#ent", "<e1>", "identified", "and", "designated", "as", "IL1RN*1", ",", "C1416402#ent", "<e2>", ",", "IL1RN*3", ",", "IL1RN*4", ",", "and", "IL1RN*5", ",", "according", "to", "the", "variable", "number", "of", "tandem", "repeats", "intron", "2"], "h": {"id": "C1504688", "name": "C1504688#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416402", "name": "C1416402#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "caspase-3", "and", "the", "cleavage", "of", "C1538577#ent", "<e1>", "inhibited", "upon", "C0812246#ent", "<e2>", "exposure", "in", "HCV", "core", "protein-expressing", "HepG2", "cells"], "h": {"id": "C1538577", "name": "C1538577#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}}
{"token": ["Levels", "of", "cleaved", "C1538577#ent", "<e1>", "FAS", "protein", "also", "elevated", "by", "C0812246#ent", "<e2>", "."], "h": {"id": "C1538577", "name": "C1538577#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [10, 11]}}
{"token": ["However", ",", "1", "-", "1/B3", "does", "not", "react", "with", "plasma", "fibrinogen", "with", "fibrin(ogen)", "degradation", "products", "by", "plasmin", "or", "by", "other", "C1947941#ent", "<e1>", "may", "occur", "locally", ",", "i.e.", "C2350349#ent", "<e2>", "and", "lysosomal", "cathepsins", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2350349", "name": "C2350349#ent", "pos": [27, 28]}}
{"token": ["C1947941#ent", "<e1>", "have", "been", "divided", "into", "four", "mechanistic", "classes", ":", "serine", "proteases", "C2350349#ent", "<e2>", ",", "aspartic", "proteases", "and", "cysteine", "proteases"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2350349", "name": "C2350349#ent", "pos": [12, 13]}}
{"token": ["The", "benzodiazepine", "derivative", "Ro", "11", "3128", ")", "which", "has", "central", "nervous", "effects", "similar", "to", "other", "C0005064#ent", "<e1>", ",", "and", "praziquantel", "(", "C1418952#ent", "<e2>", ")", ",", "are", "two", "new", "antischistosomal", "drugs"], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418952", "name": "C1418952#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "results", "of", "nuclear", "run-on", "experiments", "indicated", "that", "C3536949#ent", "<e1>", "could", "regulate", "the", "transcriptional", "rate", "the", "C1423108#ent", "<e2>"], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [17, 18]}}
{"token": ["The", "study", "of", "CNS", "pain-modulating", "pathways", "has", "led", "to", "important", "discoveries", "about", "the", "role", "of", "central", "nociceptive", "structures", "such", "as", "C1705981#ent", "<e1>", "and", "hypothalamus", "in", "the", "pathophysiology", "of", "episodic", "and", "C0009088#ent", "<e2>"], "h": {"id": "C1705981", "name": "C1705981#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0009088", "name": "C0009088#ent", "pos": [30, 31]}}
{"token": ["The", "ADP-ribosylation", "factor", "C0035436#ent", "<e1>", ")", ",", "a", "highly", "conserved", "low", "molecular", "weight", "C0086376#ent", "<e2>", "has", "been", "implicated", "to", "function", "in", "intracellular", "protein", "transport", "and", "within", "the", "Golgi", "complex"], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["GTPase", "activating", "proteins", "GAPs", ")", "of", "the", "centaurin", "family", "regulate", "the", "actin", "cytoskeleton", "vesicle", "trafficking", "through", "inactivation", "of", "the", "ADP-ribosylation", "factor", "C0035436#ent", "<e1>", ")", "family", "of", "small", "C0086376#ent", "<e2>"], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [27, 28]}}
{"token": ["These", "results", "demonstrate", "that", "C0035436#ent", "<e1>", "is", "a", "C0086376#ent", "<e2>", "structural", "features", "both", "the", "ras", "and", "the", "trimeric", "GTP-binding", "protein", "families", "."], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["Probe", "electrograms", "were", "acquired", "during", "C0004238#ent", "<e1>", "induced", "at", "baseline", "and", "after", "intravenous", "infusion", "C0082966#ent", "<e2>", "(", "0.075", "mg/kg", "followed", "by", "0.075", "mg/kg", "infusion", "over", "10", "minutes", ")", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0082966", "name": "C0082966#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "persistent", "atrial", "fibrillation", "C0004238#ent", "<e1>", ")", "who", "respond", "to", "C0082966#ent", "<e2>", "infusion", "usually", "convert", "to", "sinus", "rhythm", "within", "1", "hour", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0082966", "name": "C0082966#ent", "pos": [11, 12]}}
{"token": ["Right", "atrial", "multisite", "electrogram", "recordings", "revealed", "significant", "prolongation", "in", "C0004238#ent", "<e1>", "cycle", "length", "at", "all", "sites", "following", "C0082966#ent", "<e2>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0082966", "name": "C0082966#ent", "pos": [17, 18]}}
{"token": ["Microsomal", "triglyceride", "TG", ")", "transfer", "protein", "MTP", ")", "is", "an", "C1538611#ent", "<e1>", "of", "a", "97-kDa", "subunit", "and", "C4284026#ent", "<e2>"], "h": {"id": "C1538611", "name": "C1538611#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4284026", "name": "C4284026#ent", "pos": [17, 18]}}
{"token": ["The", "C1538611#ent", "<e1>", "homologous", "to", "C4284026#ent", "<e2>", "can", "be", "cross-linked", "to", "the", "same", "monoglucosylated", "glycoproteins", "that", "bind", "to", "calnexin", "and", "calreticulin", "."], "h": {"id": "C1538611", "name": "C1538611#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4284026", "name": "C4284026#ent", "pos": [5, 6]}}
{"token": ["C0052332#ent", "<e1>", "activity", "increased", "in", "the", "presence", "of", "arginine", "in", "C2983749#ent", "<e2>", "N8", "isolated", "from", "orange", "."], "h": {"id": "C0052332", "name": "C0052332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2983749", "name": "C2983749#ent", "pos": [10, 11]}}
{"token": ["Other", "C0035064#ent", "<e1>", "include", "pseudoephedrine", ",", "an", "oral", "vasoconstrictor", "for", "nasal", "congestion", "and", "the", "C0700580#ent", "<e2>", "rhinorrhoea", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0700580", "name": "C0700580#ent", "pos": [14, 15]}}
{"token": ["The", "mechanisms", "of", "action", "of", "these", "C0035064#ent", "<e1>", ",", "and", "also", "of", "atropinic", "drugs", "as", "C0700580#ent", "<e2>", "oxytropium", "bromide", "discussed", ",", "and", "also", "the", "benefits", "of", "using", "mixtures", "of", "drugs", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0700580", "name": "C0700580#ent", "pos": [15, 16]}}
{"token": ["The", "beneficial", "effect", "of", "C0525678#ent", "<e1>", "inhibition", "with", "the", "AII", "receptor", "antagonist", "C0287041#ent", "<e2>", "on", "diabetic", "glomerular", "was", "clearly", "demonstrated", "in", "this", "study", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [12, 13]}}
{"token": ["Clinical", "studies", "clearly", "demonstrated", "the", "benefits", "of", "C0525678#ent", "<e1>", "blockade", "alongside", "the", "additional", "effects", "beyond", "blood", "pressure", "with", "C0287041#ent", "<e2>", "treatment", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [18, 19]}}
{"token": ["Our", "findings", "may", "aid", "further", "studies", "of", "how", "C1421361#ent", "<e1>", "initiates", "mutagenic", "rather", "than", "repair", "processing", "C1421876#ent", "<e2>", "deaminase-generated", "uracil", "at", "Ig", "loci", "in", "B", "cells"], "h": {"id": "C1421361", "name": "C1421361#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421876", "name": "C1421876#ent", "pos": [16, 17]}}
{"token": ["avium", "and", "similar", "C1417679#ent", "<e1>", "existed", "in", "C0026916#ent", "<e2>", "Mycobacterium", "scrofulaceum"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026916", "name": "C0026916#ent", "pos": [7, 8]}}
{"token": ["Although", "the", "exact", "mechanism", "for", "pathophysiology", "of", "acute", "renal", "failure", "unknown", ",", "treatment", "with", "prednisolone", "and", "C1161438#ent", "<e1>", "could", "induce", "a", "rapid", "recovery", "from", "acute", "renal", "failure", "by", "Waldenstr\u00f6m's", "macroglobulinemia", "C0010403#ent", "<e2>"], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010403", "name": "C0010403#ent", "pos": [30, 31]}}
{"token": ["Immunomodulators", "such", "as", "corticosteroids", "and", "C1161438#ent", "<e1>", "are", "efficacious", "for", "palliative", "treatment", "the", "symptomatology", "of", "C0010403#ent", "<e2>", "may", "enhance", "viral", "replication"], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010403", "name": "C0010403#ent", "pos": [15, 16]}}
{"token": ["In", "the", "subset", "of", "patients", "with", "C1535939#ent", "<e1>", "no", "correlation", "apparent", "between", "discrete", "C1704942#ent", "<e2>", "lipids", "and", "clinical", "indices", "of", "disease", "severity"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [13, 14]}}
{"token": ["It", "is", "concluded", "that", "formation", "of", "the", "more", "stable", "C3537240#ent", "<e1>", "SNAC", "occurs", "on", "incubation", "of", "N-acetylcysteine", "with", "C1420270#ent", "<e2>", "or", "NO", "."], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420270", "name": "C1420270#ent", "pos": [18, 19]}}
{"token": ["The", "cause", "of", "the", "C0007785#ent", "<e1>", "considered", "as", "C0007780#ent", "<e2>", "19", "cases", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007780", "name": "C0007780#ent", "pos": [8, 9]}}
{"token": ["CT", "or", "MRI", "identify", "C0007785#ent", "<e1>", "from", "virtually", "all", "large", "C0007780#ent", "<e2>"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007780", "name": "C0007780#ent", "pos": [10, 11]}}
{"token": ["Fas-dependent", "apoptotic", "proteins", "Fas", ",", "cleaved", "caspase-8", "and", "C3641819#ent", "<e1>", "were", "reduced", "in", "liver", "from", "NZB/W", "F1", "mice", "given", "C0010637#ent", "<e2>", "as", "compared", "to", "those", "given", "PBS", "."], "h": {"id": "C3641819", "name": "C3641819#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010637", "name": "C0010637#ent", "pos": [19, 20]}}
{"token": ["The", "toxicities", "of", "three", "C0031436#ent", "<e1>", ",", "promazine", ",", "chlorpromazine", ",", "and", "C0040979#ent", "<e2>", ",", "towards", "cells", "of", "a", "mouse", "fibrosarcoma", "quantified", "by", "means", "of", "an", "in", "vitro", "assay", "of", "clonogenic", "cell", "survival"], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "pretreatment", "by", "C0031436#ent", "<e1>", "--", "Chlorpromazine", "(", "CPR", ")", "/Spofa/", "and", "C0040979#ent", "<e2>", "(", "TFP", ")", "/Smith", "Kline", "and", "French/", "on", "reperfusion", "injury", "ischemic", "myocardium", "studied", "."], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", "we", "investigated", "peripheral", "blood", "T", "cells", "10", "patients", "with", "C1839259#ent", "<e1>", ",", "focusing", "on", "the", "C1423842#ent", "<e2>", "and", "Th2", "imbalance", ",", "using", "intracellular", "cytokine", "staining", "analysis", "of", "the", "cytokine-producing", "T", "cells", "by", "flow", "cytometry"], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [18, 19]}}
{"token": ["Indications", "were", "syncope", "in", "6", "patients", ",", "C3665346#ent", "<e1>", "stroke", ",", "transient", "ischaemic", "attack", "C0751495#ent", "<e2>", "in", "one", "patients", "each", "."], "h": {"id": "C3665346", "name": "C3665346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [14, 15]}}
{"token": ["Similar", "to", "the", "clinical", "phenotype", "the", "homozygous", "mutants", "show", "C3665346#ent", "<e1>", "the", "age", "of", "8", "weeks", ",", "C0751495#ent", "<e2>", "after", "4", "months", "and", "paralysis", "of", "hind", "limbs", "the", "age", "of", "5", "months", "."], "h": {"id": "C3665346", "name": "C3665346#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [17, 18]}}
{"token": ["In", "particular", ",", "they", "examined", "the", "effect", "of", "C0052919#ent", "<e1>", "a", "specific", "inhibitor", "of", "vacuolar-type", "H(+)-ATPase", "on", "the", "degradation", "of", "C0289313#ent", "<e2>", "in", "the", "RPE", "cells", "in", "vivo"], "h": {"id": "C0052919", "name": "C0052919#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [20, 21]}}
{"token": ["Two", "hundred", "and", "seventy-two", "patients", "with", "C0005747#ent", "<e1>", "reviewed", "to", "establish", "the", "role", "of", "C0015397#ent", "<e2>", "their", "illness", "."], "h": {"id": "C0005747", "name": "C0005747#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [14, 15]}}
{"token": ["A", "strong", "correlation", "was", "found", "between", "C0026603#ent", "<e1>", "emetic", "sequelae", "surgery", ",", "and", "patients", "with", "a", "history", "of", "C0026603#ent", "<e1>", "most", "from", "C0036442#ent", "<e1>", "."], "h": {"id": "C0026603", "name": "C0026603#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [22, 23]}}
{"token": ["Treatment", "of", "C0026603#ent", "<e1>", "induced", "by", "parabolic", "flight", "with", "a", "preparation", "of", "C0036442#ent", "<e2>", "placed", "in", "the", "buccal", "pouch", "investigated", "."], "h": {"id": "C0026603", "name": "C0026603#ent", "pos": [2, 3]}, "relation": "may_be_prevented_by", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [12, 13]}}
{"token": ["C0026691#ent", "<e1>", "values", "for", "C3266846#ent", "<e2>", "and", "some", "sulphonamides", "as", "well", "as", "for", "L-glutamate", ",", "L-gamma-glutamyl", "oligopeptides", "some", "pteridines", "and", "folate", "antagonists", "also", "presented", "in", "order", "to", "illustrate", "the", "specificity", "of", "the", "receptor", "protein"], "h": {"id": "C0026691", "name": "C0026691#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3266846", "name": "C3266846#ent", "pos": [4, 5]}}
{"token": ["Here", "it", "is", "reported", "that", "a", "plant", "gene", "isolated", "from", "male", "germline", "cells", "lily", "(", "Lilium", "longiflorum", "shows", "a", "striking", "amino", "acid", "sequence", "to", "the", "DNA", "excision", "repair", "proteins", "human", "C1333483#ent", "<e1>", "and", "yeast", "C1333355#ent", "<e2>", "."], "h": {"id": "C1333483", "name": "C1333483#ent", "pos": [30, 31]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333355", "name": "C1333355#ent", "pos": [34, 35]}}
{"token": ["The", "phenotype", "of", "CHO", "cells", "genetic", "complementation", "group", "2", "also", "specifically", "complemented", "by", "the", "human", "C1333483#ent", "<e1>", "gene", ",", "and", "the", "C1333483#ent", "<e1>", "and", "C1333355#ent", "<e1>", "similar", "amino", "acid", "sequences"], "h": {"id": "C1333483", "name": "C1333483#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333355", "name": "C1333355#ent", "pos": [24, 25]}}
{"token": ["Following", "prenylation", ",", "these", "C0086376#ent", "<e1>", "usually", "undergo", "endoproteolytic", "processing", "the", "C1422161#ent", "<e2>", "then", "carboxyl", "methylation", "a", "unique", "methyltransferase", "known", "as", "isoprenylcysteine", "carboxyl", "methyltransferase", "ICMT", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422161", "name": "C1422161#ent", "pos": [11, 12]}}
{"token": ["These", "C0086376#ent", "<e1>", "have", "been", "tentatively", "called", "Face-1", "and", "C1422161#ent", "<e2>", "(", "farnesylated", "protein-converting", "enzymes", "1", "and", "2", ")", ",", "respectively", ",", "and", "are", "integral", "membrane", "proteins", "belonging", "to", "distinct", "families", "of", "metalloproteinases", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1422161", "name": "C1422161#ent", "pos": [9, 10]}}
{"token": ["The", "hypotensive", "mechanism", "of", "adrenergic", "alpha", "blockers", "related", "to", "their", "inhibitory", "effect", "on", "the", "contractile", "Ca-mechanism", "in", "C1412137#ent", "<e1>", "in", "nitroglycerin", "or", "C0280858#ent", "<e2>", "."], "h": {"id": "C1412137", "name": "C1412137#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [22, 23]}}
{"token": ["The", "cardiovascular", "effects", "CP-96,345", "and", "CP-96,344", "in", "isolated", "C1412137#ent", "<e1>", "in", "anesthetized", "dogs", "were", "compared", "to", "those", "of", "C0280858#ent", "<e2>", "and", "nifedipine", ",", "phenylalkylamine", "and", "dihydropyridine", "Ca2", "+", "channel", "antagonists", ",", "respectively", "."], "h": {"id": "C1412137", "name": "C1412137#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [18, 19]}}
{"token": ["Lyme", "disease", "the", "multisystem", "infectious", "disease", "by", "the", "tick-borne", "spirochete", "Borrelia", "burgdorferi", "causes", "a", "broad", "variety", "of", "C0031117#ent", "<e1>", "including", "single", "or", "C0010266#ent", "<e2>", "painful", "radiculopathies", "and", "diffuse", "polyneuropathies"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0010266", "name": "C0010266#ent", "pos": [22, 23]}}
{"token": ["The", "diseases", "causing", "end-stage", "kidney", "failure", "recipients", "were", "C1567741#ent", "<e1>", "amyloidosis", ",", "cystinosis", ",", "diabetes", "mellitus", "Fabry", "disease", "C0027706#ent", "<e2>", "gout", ",", "medullary", "cystic", "disease", "oxalosis", ",", "and", "systemic", "lupus", "erythematosus"], "h": {"id": "C1567741", "name": "C1567741#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027706", "name": "C0027706#ent", "pos": [18, 19]}}
{"token": ["C1567741#ent", "<e1>", "to", "the", "clinical", "triad", "C0027706#ent", "<e2>", "sensorineural", "deafness", "and", "ocular", "abnormalities"], "h": {"id": "C1567741", "name": "C1567741#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027706", "name": "C0027706#ent", "pos": [6, 7]}}
{"token": ["C1567741#ent", "<e1>", "AS", ")", "is", "a", "C0027706#ent", "<e2>", "associated", "with", "neural", "hearing", "loss", "ocular", "abnormalities"], "h": {"id": "C1567741", "name": "C1567741#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027706", "name": "C0027706#ent", "pos": [6, 7]}}
{"token": ["The", "actions", "of", "STa", ",", "including", "binding", "to", "its", "receptor", ",", "activation", "of", "C0018358#ent", "<e1>", "stimulation", "of", "electrolyte", "transport", "are", "rapid", ",", "reversible", "and", "C1420295#ent", "<e2>", "."], "h": {"id": "C0018358", "name": "C0018358#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [24, 25]}}
{"token": ["In", "the", "present", "study", ",", "the", "uptake", "of", "C0022635#ent", "<e1>", ",", "indomethacin", ",", "and", "C0036077#ent", "<e2>", "by", "freshly", "isolated", "rat", "hepatocytes", "was", "characterized", "."], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [14, 15]}}
{"token": ["Many", "other", "analgesics", "such", "as", "C0022635#ent", "<e1>", ",", "daypro", "and", "C0036077#ent", "<e2>", "can", "also", "be", "determined", "by", "this", "method", "."], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [10, 11]}}
{"token": ["In", "further", "support", "of", "the", "concept", "that", "C1259877#ent", "<e1>", "activation", "mediated", "the", "effect", "of", "platelet-activating", "factor", "the", "specific", "C1514555#ent", "<e2>", "staurosporine", "reversed", "the", "ability", "of", "platelet-activating", "factor", "augment", "induction", "of", "macrophage", "procoagulant", "activity", "endotoxin", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1514555", "name": "C1514555#ent", "pos": [18, 19]}}
{"token": ["Both", "the", "Ha-ras", "and", "the", "bombesin-induced", "stimulation", "of", "the", "furosemide-sensitive", "Rb+", "transport", "be", "blocked", "by", "C1259877#ent", "<e1>", "depletion", "or", "the", "C1514555#ent", "<e2>", "staurosporine", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1514555", "name": "C1514555#ent", "pos": [20, 21]}}
{"token": ["Twenty", "men", "and", "33", "women", "with", "C0020476#ent", "<e1>", "asymptomatic", "as", "regards", "C0151744#ent", "<e2>", "investigated", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "genes", "of", "apolipoprotein", "E", "apoE", ")", ",", "LDLP", "receptor", "methylentetrahydrofolate", "reductase", "MTHFR", ")", "in", "a", "female", "patient", "with", "C0020476#ent", "<e1>", "HLP", ")", "and", "early", "C0151744#ent", "<e2>", "IHD", ")", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [26, 27]}}
{"token": ["In", "this", "sense", ",", "familial", "hypercholesterolemia", "a", "clinically", "important", "C0020476#ent", "<e1>", "of", "its", "high", "risk", "C0151744#ent", "<e2>", "its", "high", "prevalence", "in", "a", "normal", "population", "1/500", ")", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [15, 16]}}
{"token": ["Screening", "of", "the", "C1414493#ent", "<e1>", "the", "novel", "C1419599#ent", "<e2>", "variation", "ca", "."], "h": {"id": "C1414493", "name": "C1414493#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419599", "name": "C1419599#ent", "pos": [7, 8]}}
{"token": ["C0221021#ent", "<e1>", "a", "typical", "hematological", "feature", "of", "the", "syndromes", "characterized", "by", "C2717961#ent", "<e2>", "histopathological", "lesion", "(", "hemolytic", "uremic", "syndrome", "thrombotic", "thrombocytopenic", "purpura", "."], "h": {"id": "C0221021", "name": "C0221021#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [11, 12]}}
{"token": ["This", "was", "confirmed", "by", "the", "detection", "of", "a", "mutation", "within", "C1420172#ent", "<e1>", ",", "the", "gene", "encoding", "the", "C3500855#ent", "<e2>", "facilitative", "glucose", "transporter", "."], "h": {"id": "C1420172", "name": "C1420172#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3500855", "name": "C3500855#ent", "pos": [17, 18]}}
{"token": ["In", "six", "healthy", "mares", "and", "24", "mares", "showing", "C0178829#ent", "<e1>", "swab", "samples", "taken", "from", "the", "fossa", "clitoridis", "to", "C1875400#ent", "<e2>", "Taylorella", "equigenitalis", "and", "from", "the", "uterus", "to", "C1875400#ent", "<e2>", "mycoplasmas", ",", "ureaplasmas", "and", "other", "aerobic", "bacteria"], "h": {"id": "C0178829", "name": "C0178829#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [18, 19]}}
{"token": ["In", "large", "plots", ",", "the", "main", "C3272498#ent", "<e1>", "bell", "peppers", "protected", "from", "the", "majority", "of", "the", "oviposition", "and", "C0030499#ent", "<e2>", "by", "all", "three", "barriers", "."], "h": {"id": "C3272498", "name": "C3272498#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [18, 19]}}
{"token": ["C0532261#ent", "<e1>", "is", "an", "orally", "active", ",", "potent", "and", "selective", "C2936609#ent", "<e2>", "inhibitor", "."], "h": {"id": "C0532261", "name": "C0532261#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936609", "name": "C2936609#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", "to", "rolipram", ",", "C0532261#ent", "<e1>", "acted", "as", "a", "simple", "competitive", "inhibitor", "of", "all", "C2936609#ent", "<e2>", "isoenzymes", "."], "h": {"id": "C0532261", "name": "C0532261#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936609", "name": "C2936609#ent", "pos": [15, 16]}}
{"token": ["and", "C1336623#ent", "<e1>", ")", "and", "two", "non-malignant", "(", "HUVEC", "and", "C1418865#ent", "<e2>", ")", ",", "were", "used", "."], "h": {"id": "C1336623", "name": "C1336623#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418865", "name": "C1418865#ent", "pos": [10, 11]}}
{"token": ["Two", "clinical", "C1875400#ent", "<e1>", "of", "Yersinia", "enterocolitica", "biotype", "1", "positive", "for", "indole", "and", "C0031671#ent", "<e2>", "production", ",", "xylose", "and", "salicin", "fermentation", "and", "aesculin", "hydrolysis", ",", "are", "reported", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [13, 14]}}
{"token": ["Cells", "grown", "aerobically", "with", "C0220795#ent", "<e1>", "contained", "a", "benzoate-CoA", "ligase", "AMP", "forming", ")", "(", "0.1", "mumol", "min-1", "mg-1", ")", "which", "converted", "C0220795#ent", "<e1>", "but", "not", "C0000500#ent", "<e1>", "into", "its", "CoA", "thioester"], "h": {"id": "C0220795", "name": "C0220795#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000500", "name": "C0000500#ent", "pos": [25, 26]}}
{"token": ["These", "syndromes", "have", "abnormal", "limb", "development", "and/or", "C0013575#ent", "<e1>", "include", "ectrodactyly", ",", "C0013575#ent", "<e1>", "clefting", "syndrome", ";", "ankyloblepharon", ",", "C0013575#ent", "<e1>", "clefting", "syndrome", ";", "acro-dermato-ungual-lacrimal-tooth", "syndrome", ";", "C1863753#ent", "<e1>", "as", "well", "as", "nonsyndromic", "split", "hand/foot", "malformation"], "h": {"id": "C0013575", "name": "C0013575#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1863753", "name": "C1863753#ent", "pos": [27, 28]}}
{"token": ["Laboratory", "tests", "including", "complete", "blood", "count", "CBC", ")", ",", "liver", "function", "tests", "helper/inducer", "T", "lymphocyte", "numbers", "CD4", ")", ",", "serum", "C0012050#ent", "<e1>", "numbers", ",", "and", "C4082696#ent", "<e2>", "concentrations", "were", "examined", "."], "h": {"id": "C0012050", "name": "C0012050#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C4082696", "name": "C4082696#ent", "pos": [25, 26]}}
{"token": ["administration", "of", "an", "anti-cholinergic", "(", "atropine", "sulfate", ",", "two", "C3540024#ent", "<e1>", "(", "pyridostigmine", "bromide", "physostigmine", "salicylate", ",", "and", "combinations", "of", "C0034261#ent", "<e2>", "and", "atropine", "."], "h": {"id": "C3540024", "name": "C3540024#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034261", "name": "C0034261#ent", "pos": [20, 21]}}
{"token": ["C0393743#ent", "<e1>", "CPH", ")", "is", "a", "rare", "type", "of", "C0270697#ent", "<e2>", "that", "is", "characterized", "by", "daily", ",", "multiple", ",", "short-lasting", "attacks", "of", "severe", "pain", "and", "associated", "autonomic", "symptoms"], "h": {"id": "C0393743", "name": "C0393743#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [9, 10]}}
{"token": ["C0393743#ent", "<e1>", "gradually", "become", "a", "well-established", "C0270697#ent", "<e2>", "entity", "."], "h": {"id": "C0393743", "name": "C0393743#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [6, 7]}}
{"token": ["The", "consequences", "of", "repeated", "exposure", "of", "adult", "mice", "to", "sub-toxic", "doses", "of", "C0052919#ent", "<e1>", "concanamycin", "A", "examined", "by", "injection", "of", "the", "C0282563#ent", "<e2>", "on", "each", "of", "five", "consecutive", "days", "."], "h": {"id": "C0052919", "name": "C0052919#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282563", "name": "C0282563#ent", "pos": [21, 22]}}
{"token": ["The", "protein", "kinase", "C", "PKC", ")", "inhibitor", "C1413096#ent", "<e1>", "31", "-", "8220", "markedly", "reduced", "P2", "purinoceptor-mediated", "C0812312#ent", "<e2>", "induction", "."], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "identify", "the", "transcriptional", "repressor", "C1538143#ent", "<e1>", "(", "encoded", "by", "the", "C1705361#ent", "<e2>", "as", "a", "critical", "factor", "in", "oncogenesis", "."], "h": {"id": "C1538143", "name": "C1538143#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1705361", "name": "C1705361#ent", "pos": [12, 13]}}
{"token": ["The", "transcriptional", "repressor", "C1538143#ent", "<e1>", ",", "also", "known", "as", "C1705361#ent", "<e2>", ",", "has", "recently", "been", "identified", "as", "a", "critical", "factor", "oncogenesis", "."], "h": {"id": "C1538143", "name": "C1538143#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1705361", "name": "C1705361#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "C1332794#ent", "<e1>", "indeed", "participates", "in", "the", "regulation", "of", "the", "C1307053#ent", "<e2>", "mitosis", "."], "h": {"id": "C1332794", "name": "C1332794#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [13, 14]}}
{"token": ["Conversely", ",", "kinase-inactive", "C1332794#ent", "<e1>", "caused", "an", "increase", "in", "C1307053#ent", "<e2>", "bone", "resorbing", "activity", "the", "cells", "both", "in", "vitro", "in", "vivo", "acting", "as", "a", "dominant", "negative", "molecule", "against", "intrinsic", "C1332794#ent", "<e1>", "."], "h": {"id": "C1332794", "name": "C1332794#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [9, 10]}}
{"token": ["In", "the", "presence", "of", "TMB-8", ",", "which", "attenuated", "the", "C3273406#ent", "<e1>", "10(-8)M)-induced", "rise", "in", "[Ca(2+)](i", ")", "by", "66", "%", ",", "C0012384#ent", "<e2>", "(", "10(-6)M", ")", "had", "no", "additional", "suppressive", "effect", "[Ca(2+)](i", ")", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012384", "name": "C0012384#ent", "pos": [20, 21]}}
{"token": ["In", "general", ",", "C1417750#ent", "<e1>", "had", "no", "effect", "serum", "enzymes", "SGOT", ",", "C0376147#ent", "<e2>", ",", "LDH", ",", "HBDH", ")", ",", "but", "it", "increased", "blood", "urea", "nitrogen", "BUN", ")", "and", "serum", "creatinine", "h", "after", "administration", "."], "h": {"id": "C1417750", "name": "C1417750#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0376147", "name": "C0376147#ent", "pos": [12, 13]}}
{"token": ["C0012091#ent", "<e1>", "is", "present", "on", "the", "market", "as", "free", "acid", "as", "sodium", "salt", "C1413749#ent", "<e2>", "15307", "-", "79", "-", "6", ")", "and", "as", "potassium", "salt", "C1413749#ent", "<e2>", "15307", "-", "81", "-", "0", ")", "."], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413749", "name": "C1413749#ent", "pos": [13, 14]}}
{"token": ["Dominant", "negative", "studies", "that", "Shc", "mediates", "the", "early", "phase", "peak", ",", "whereas", "FAK", ",", "p130(CAS", ")", ",", "C0812252#ent", "<e1>", ",", "and", "Rap1", "contribute", "to", "the", "late", "phase", "integrin-dependent", "activation", "C1366882#ent", "<e2>", "in", "these", "cells", "."], "h": {"id": "C0812252", "name": "C0812252#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [29, 30]}}
{"token": ["Pyk2-induced", "activation", "of", "Src", "is", "necessary", "for", "phosphorylation", "of", "Shc", "and", "p130Cas", "and", "their", "association", "with", "Grb2", "and", "C0812252#ent", "<e1>", ",", "respectively", ",", "and", "for", "the", "activation", "of", "C1366882#ent", "<e2>", "and", "JNK", "cascades"], "h": {"id": "C0812252", "name": "C0812252#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [28, 29]}}
{"token": ["Overexpression", "of", "cDNAs", "encoding", "B-RAF", ",", "C0812252#ent", "<e1>", "W109L", ",", "and", "PTP1B", "C215S", "activated", "C1366882#ent", "<e2>", "in", "suspension", "cells", "the", "latter", "two", "constructs", "also", "disrupting", "CRKII-C3", "G", "complex", "formation", "."], "h": {"id": "C0812252", "name": "C0812252#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [14, 15]}}
{"token": ["We", "determined", "fluctuations", "in", "circulating", "lymphocyte", "subsets", "induced", "by", "methylprednisolone", "pulse", "therapy", "MPT", ")", "and", "the", "continuous", "administration", "C0032950#ent", "<e1>", "(", "PSL", ")", "in", "17", "patients", "with", "autoimmune", "or", "C0035435#ent", "<e2>"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [29, 30]}}
{"token": ["We", "assessed", "the", "diagnostic", "value", "CD8+", "levels", "in", "a", "larger", "group", "of", "patients", "with", "temporal", "arteritis", "polymyalgia", "rheumatica", "and", "after", "treatment", "with", "C0032950#ent", "<e1>", "and", "in", "relation", "to", "patients", "with", "other", "medical", "and", "C0035435#ent", "<e2>"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [33, 34]}}
{"token": ["It", "is", "a", "C0042402#ent", "<e1>", "calcium", "antagonist", "afterload", "reducer", ",", "C3537142#ent", "<e2>", ",", "and", "antiplatelet", "drug", "modulates", "autonomic", "function", "limits", "reperfusion", "injury", "administered", "early", "in", "infarction", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537142", "name": "C3537142#ent", "pos": [10, 11]}}
{"token": ["These", "haemodynamic", "and", "electrophysiological", "changes", "suggest", "that", "this", "compound", "is", "an", "effective", "C0042402#ent", "<e1>", "and", "may", "have", "potential", "C3537142#ent", "<e2>", "properties", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3537142", "name": "C3537142#ent", "pos": [18, 19]}}
{"token": ["C3899480#ent", "<e1>", "catalyzing", "1alpha-hydroxylation", "and", "C1413864#ent", "<e2>", "but", "not", "24-hydroxylation", "of", "25-hydroxyvitamin", "D3", "was", "partially", "purified", "from", "pig", "kidney"], "h": {"id": "C3899480", "name": "C3899480#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413864", "name": "C1413864#ent", "pos": [5, 6]}}
{"token": ["C2936885#ent", "<e1>", "treatment", "caused", "phosphorylation", "of", "Akt", "and", "downstream", "signaling", "such", "as", "C0244988#ent", "<e2>", ",", "mTOR", ",", "and", "S6", "kinase"], "h": {"id": "C2936885", "name": "C2936885#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [12, 13]}}
{"token": ["Obstructive", "airway", "disease", "bronchiectasis", ",", "non-specific", "parenchymal", "infiltration", "and", "bronchiolitis", "obliterans", "C0032285#ent", "<e1>", "are", "seen", "occasionally", "in", "patients", "with", "C0010346#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [19, 20]}}
{"token": ["Pathologic", "findings", "to", "adenovirus", "infection", "C0032285#ent", "<e1>", "with", "or", "without", "intra-alveolar", "hemorrhage", "hepatic", "necrosis", "C0010346#ent", "<e2>", "with", "or", "without", "mucosal", "hemorrhage", "epicardial", "hemorrhage", "and", "ulcerations", "of", "the", "larynx", ",", "trachea", ",", "and", "ileum", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "indicate", "that", "endosome-to-Golgi", "transport", "of", "Shiga", "toxin", "dependent", "on", "functional", "C0058836#ent", "<e1>", "in", "both", "untreated", "cells", "and", "in", "cells", "treated", "with", "C1161319#ent", "<e2>"], "h": {"id": "C0058836", "name": "C0058836#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1161319", "name": "C1161319#ent", "pos": [23, 24]}}
{"token": ["Similarly", "C1510932#ent", "<e1>", "interact", "with", "C0132555#ent", "<e2>", "aromatase", "inhibitors", "block", "implantation", "action", "on", "the", "endometrium", "."], "h": {"id": "C1510932", "name": "C1510932#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [5, 6]}}
{"token": ["MAG", "can", "be", "phosphorylated", "at", "tyrosine", "by", "the", "v-fps", "and", "C0282625#ent", "<e1>", "in", "vitro", "by", "a", "C0031727#ent", "<e2>", "endogenous", "to", "myelin", "membrane", "preparations", "."], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [10, 11]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [16, 17]}}
{"token": ["We", "also", "demonstrated", "inhibition", "of", "TCR", "signalling", "C0282625#ent", "<e1>", "and", "predicted", "that", "inhibition", "of", "LCK", "and", "other", "C0031727#ent", "<e2>", "involved", "in", "T-cell", "signalling", "dasatinib", "is", "responsible", "for", "the", "suppression", "of", "T-cell", "function"], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["Chemical", "inhibition", "C0282625#ent", "<e1>", "a", "role", "for", "these", "C0031727#ent", "<e2>", "in", "Tarp", "phosphorylation", "."], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}}
{"token": ["C1414634#ent", "<e1>", "in", "the", "C1538565#ent", "<e2>", "correlated", "positively", "with", "to", "the", "immobility", "time", "and", "negatively", "with", "to", "climbing", "behavior", "scored", "during", "the", "test", "."], "h": {"id": "C1414634", "name": "C1414634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538565", "name": "C1538565#ent", "pos": [4, 5]}}
{"token": ["C2987163#ent", "<e1>", "forms", "a", "complex", "with", "hsp90", "and", "the", "C0596123#ent", "<e2>", "but", "can", "also", "bind", "to", "both", "independently", "."], "h": {"id": "C2987163", "name": "C2987163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0596123", "name": "C0596123#ent", "pos": [9, 10]}}
{"token": ["The", "aryl", "hydrocarbon", "receptor-associated", "protein-9", "(", "C2987163#ent", "<e1>", ")", "is", "a", "chaperone", "of", "the", "C0596123#ent", "<e2>", "AHR", ")", "."], "h": {"id": "C2987163", "name": "C2987163#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0596123", "name": "C0596123#ent", "pos": [14, 15]}}
{"token": ["In", "adults", ",", "C0003864#ent", "<e1>", "most", "like", "Reiter's", "syndrome", "C0085435#ent", "<e2>", "and", "in", "children", ",", "it", "is", "most", "similar", "to", "the", "pauciarticular", "form", "of", "juvenile", "rheumatoid", "arthritis"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0085435", "name": "C0085435#ent", "pos": [9, 10]}}
{"token": ["High-performance", "liquid", "chromatography", "used", "to", "assess", "simultaneously", "the", "concentration", "and", "MW", "of", "HA", "in", "SF", "obtained", "from", "horses", "with", "various", "C0003864#ent", "<e1>", ":", "acute", "traumatic", "arthritis", "chronic", "traumatic", "arthritis", "including", "degenerative", "joint", "disease", "DJD", ")", ";", "and", "C0085435#ent", "<e2>"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [20, 21]}, "relation": "nichd_parent_of", "t": {"id": "C0085435", "name": "C0085435#ent", "pos": [37, 38]}}
{"token": ["Electromyography", "was", "used", "to", "localize", "C0013421#ent", "<e1>", "guide", "Dysport", "injections", "in", "Meige's", "syndrome", "C2242577#ent", "<e2>", "cervical", "dystonia", "and", "writer's", "cramp"], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2242577", "name": "C2242577#ent", "pos": [13, 14]}}
{"token": ["Half", "of", "the", "patients", "(", "47", "%", ")", "had", "associated", "C0013421#ent", "<e1>", ",", "including", "cervical", "dystonia", "writer's", "cramp", "spasmodic", "dysphonia", "and", "C2242577#ent", "<e2>", "and", "20", "%", "of", "the", "patients", "had", "associated", "parkinsonism", "."], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2242577", "name": "C2242577#ent", "pos": [21, 22]}}
{"token": ["A", "significant", "inverse", "association", "between", "age", "at", "the", "onset", "of", "C0013421#ent", "<e1>", "and", "education", "was", "observed", "in", "both", "C2242577#ent", "<e2>", "upper", "limb", "dystonia", "series", "."], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2242577", "name": "C2242577#ent", "pos": [18, 19]}}
{"token": ["They", "include", "the", "C0013421#ent", "<e1>", "blepharospasmus", "and", "other", "facial", "dystonias", "C2242577#ent", "<e2>", "pharyngeal", "dystonia", "spasmodic", "dysphonia", "external", "laryngeal", "dystonia", "spasmodic", "torticollis", "lingual", "dystonia"], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2242577", "name": "C2242577#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggest", "that", "C3539739#ent", "<e1>", "is", "mainly", "metabolized", "by", "the", "CYP2C", "subfamily", "human", "liver", ",", "and", "that", "C3539739#ent", "<e1>", "inhibits", "human", "steroidogenic", "C1706114#ent", "<e1>", "activities", "."], "h": {"id": "C3539739", "name": "C3539739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706114", "name": "C1706114#ent", "pos": [23, 24]}}
{"token": ["Additionally", ",", "the", "effect", "of", "C3539739#ent", "<e1>", "on", "the", "progesterone", "17alpha-chydroxylase", "activity", "C1706114#ent", "<e2>", "was", "investigated", "."], "h": {"id": "C3539739", "name": "C3539739#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706114", "name": "C1706114#ent", "pos": [12, 13]}}
{"token": ["Pancreatitis-associated", "protein", "C1424700#ent", "<e1>", ")", "is", "a", "C1332754#ent", "<e2>", "normally", "expressed", "in", "healthy", "pancreas", "highly", "induced", "during", "acute", "pancreatitis"], "h": {"id": "C1424700", "name": "C1424700#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [7, 8]}}
{"token": ["C0288792#ent", "<e1>", "is", "a", "new", "C0035339#ent", "<e2>", "has", "proven", "to", "be", "efficacious", "in", "the", "treatment", "of", "mild-to-moderate", "plaque", "psoriasis", "."], "h": {"id": "C0288792", "name": "C0288792#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [5, 6]}}
{"token": ["Topical", "administration", "C0288792#ent", "<e1>", "requires", "dosages", "much", "smaller", "than", "those", "usually", "required", "for", "C0035339#ent", "<e2>", "such", "as", "isotretinoin", ",", "acitretin", "and", "etretinate", ",", "and", "it", "delivers", "the", "drug", "directly", "into", "the", "target", "skin", "tissues"], "h": {"id": "C0288792", "name": "C0288792#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [13, 14]}}
{"token": ["Those", "which", "act", "in", "a", "comedolytic", "and", "anticomedogenic", "manner", "are", "the", "retinoids", "tretinoin", "isotretinoin", ",", "adapalene", "and", "C0288792#ent", "<e1>", "and", "azelaic", "acid", "well", ",", "some", "of", "the", "C0035339#ent", "<e2>", "having", "additional", "anti-inflammatory", "potency"], "h": {"id": "C0288792", "name": "C0288792#ent", "pos": [17, 18]}, "relation": "has_structural_class", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [27, 28]}}
{"token": ["C0288792#ent", "<e1>", "is", "the", "first", "C0035339#ent", "<e2>", "to", "be", "both", "effective", "and", "tolerable", "in", "the", "treatment", "of", "psoriasis", "."], "h": {"id": "C0288792", "name": "C0288792#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [5, 6]}}
{"token": ["BaP", "treatment", "did", "not", "induce", "DNA", "adduct", "in", "HEK293", "cells", "even", "after", "transfection", "of", "C1705794#ent", "<e1>", "C3540790#ent", "<e2>", ",", "suggesting", "that", "expression", "of", "C1705794#ent", "<e1>", "C3540790#ent", "<e2>", "is", "not", "sufficient", "for", "DNA", "adduct", "formation"], "h": {"id": "C1705794", "name": "C1705794#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}}
{"token": ["The", "authors", "present", "their", "experience", "with", "the", "surgical", "treatment", "ascites", "in", "patients", "with", "C1623038#ent", "<e1>", "of", "the", "liver", "by", "means", "of", "a", "peritoneovenous", "shunt", "C3890010#ent", "<e2>", ")", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3890010", "name": "C3890010#ent", "pos": [24, 25]}}
{"token": ["Seven", "patients", "aged", "13", "to", "17.5", "years", "developed", "acute", "renal", "failure", "treatment", "with", "a", "variety", "of", "non-steroidal", "anti-inflammatory", "drugs", "NSAID", ")", ":", "C0027396#ent", "<e1>", ",", "diclofenac", ",", "ibuprofen", ",", "C0012586#ent", "<e2>", "and", "paracetamol", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0012586", "name": "C0012586#ent", "pos": [29, 30]}}
{"token": ["Transcription", "of", "C3541915#ent", "<e1>", "was", "observed", "whether", "or", "not", "the", "C1875400#ent", "<e2>", "studied", "expressed", "the", "RESA", "protein"], "h": {"id": "C3541915", "name": "C3541915#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [10, 11]}}
{"token": ["To", "report", "the", "initial", "clinical", "experience", "with", "fibrinogen", "depletion", "C0002823#ent", "<e1>", "as", "prophylaxis", "and", "treatment", "for", "C0149871#ent", "<e2>", "pulmonary", "embolism", "DVT/PE", ")", "in", "patients", "with", "multiple", "trauma"], "h": {"id": "C0002823", "name": "C0002823#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [16, 17]}}
{"token": ["Taken", "together", ",", "JAM4", "itself", "activates", "C0285558#ent", "<e1>", "and", "may", "augment", "Rac", "activation", "C1420314#ent", "<e2>", ",", "resulting", "in", "the", "enhancement", "of", "branching", "and", "scattering", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [13, 14]}}
{"token": ["The", "neuroepithelium", "gives", "rise", "to", "the", "neural", "crest", "and", "C1335192#ent", "<e1>", "expression", "in", "cardiac", "neural", "crest", "C3273602#ent", "<e2>", ")", "is", "required", "for", "C3273602#ent", "<e2>", "migration", "to", "the", "heart", "and", "for", "outflow", "tract", "septation", "."], "h": {"id": "C1335192", "name": "C1335192#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273602", "name": "C3273602#ent", "pos": [16, 17]}}
{"token": ["In", "untreated", "strips", ",", "C0014479#ent", "<e1>", "exhibited", "dose-dependent", "contractions", "which", "were", "blocked", "by", "C0242430#ent", "<e2>", "."], "h": {"id": "C0014479", "name": "C0014479#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242430", "name": "C0242430#ent", "pos": [13, 14]}}
{"token": ["The", "disposition", "and", "effect", "on", "hemostasis", "of", "a", "single", "150", "mg", "dose", "of", "C0038792#ent", "<e1>", "was", "studied", "in", "young", "healthy", "and", "in", "older", "patients", "C0029408#ent", "<e2>", "."], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [24, 25]}}
{"token": ["A", "62-year-old", "black", "woman", "was", "given", "a", "prescription", "for", "C0038792#ent", "<e1>", "150", "mg", "twice", "daily", "to", "relieve", "pain", "associated", "with", "C0029408#ent", "<e2>"], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [20, 21]}}
{"token": ["For", "1.5", "years", "the", "patient", "had", "occasionally", "been", "taking", "a", "non-steroidal", "anti-inflammatory", "drug", "C0038792#ent", "<e1>", "(", "clinoril", ",", "MSD", ",", "New", "York", ",", "for", "C0029408#ent", "<e2>", "."], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [24, 25]}}
{"token": ["Much", "of", "what", "is", "currently", "accepted", "on", "the", "natural", "history", "C0343378#ent", "<e1>", "its", "relationship", "with", "gastric", "adenocarcinoma", "on", "the", "assumption", "that", "C0017154#ent", "<e2>", "be", "correctly", "identified", "and", "reproducibly", "recognized", "."], "h": {"id": "C0343378", "name": "C0343378#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017154", "name": "C0017154#ent", "pos": [21, 22]}}
{"token": ["In", "approximately", "half", "of", "the", "cases", ",", "C0343378#ent", "<e1>", "(", "years", ",", "decades", ")", "develops", "to", "C0017154#ent", "<e2>", "thereby", "resulting", "in", "severe", "abnormalities", "in", "the", "function", "of", "the", "stomach", "."], "h": {"id": "C0343378", "name": "C0343378#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017154", "name": "C0017154#ent", "pos": [16, 17]}}
{"token": ["The", "RFLP", "obtained", "represent", "the", "first", "standard", "patterns", "for", "the", "individual", "haplotypes", "C1333247#ent", "<e1>", "through", "7", "and", "DR9", "as", "defined", "by", "C1516876#ent", "<e2>", "homozygous", "lines"], "h": {"id": "C1333247", "name": "C1333247#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [21, 22]}}
{"token": ["This", "action", "of", "ZK", "98734", "is", "abolished", "by", "C3536807#ent", "<e1>", ",", "an", "inhibitor", "of", "protein", "synthesis", "by", "the", "calcium", "channel", "blocker", "C0042523#ent", "<e2>", "."], "h": {"id": "C3536807", "name": "C3536807#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [21, 22]}}
{"token": ["The", "addition", "of", "calpain", "to", "the", "nuclear", "fraction", "ST-13", "adipocytes", "resulted", "in", "the", "Ca(2+)-dependent", "degradation", "of", "C1335238#ent", "<e1>", "and", "C/EBPalpha", "but", "not", "C1420398#ent", "<e2>"], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420398", "name": "C1420398#ent", "pos": [22, 23]}}
{"token": ["Moreover", ",", "the", "mRNA", "expression", "of", "cyclin", "D1", "increased", "in", "these", "cells", "whereas", "the", "expression", "of", "C1335238#ent", "<e1>", "PPARgamma", ")", "and", "steroyl", "regulatory", "element", "binding", "protein", "C1420398#ent", "<e2>", ")", "was", "significantly", "reduced", "during", "early", "stages"], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420398", "name": "C1420398#ent", "pos": [26, 27]}}
{"token": ["To", "C1875400#ent", "<e1>", "the", "effects", "of", "individual", "activated", "protein", "C", "cleavage", "sites", "C0015505#ent", "<e2>", "we", "engineered", "mutations", "of", "the", "activated", "protein", "C", "cleavage", "sites", "the", "disulfide", "bond-cross-linked", "factor", "VIII", "variant", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015505", "name": "C0015505#ent", "pos": [12, 13]}}
{"token": ["In", "the", "C0265316#ent", "<e1>", "--", "von", "Recklinghausen's", "disease", "the", "Sturge-Weber", "syndrome", "tuberous", "sclerosis", "and", "C0019562#ent", "<e2>", "pathologic", "changes", "the", "eye", "are", "often", "evident", "."], "h": {"id": "C0265316", "name": "C0265316#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "basal", "C1415619#ent", "<e1>", "immunoreactivity", "identified", "in", "C3537450#ent", "<e2>", "-", "7", "cells", ",", "was", "significantly", "up-regulated", "by", "hemin", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537450", "name": "C3537450#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "C0034403#ent", "<e1>", "treatment", "reduced", "BAL", "fluid", "C0014457#ent", "<e2>", "and", "signs", "of", "allergic", "airway", "inflammation", "such", "as", "perivascular", "and", "peribronchial", "distribution", "of", "inflammatory", "cells"], "h": {"id": "C0034403", "name": "C0034403#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [9, 10]}}
{"token": ["The", "combination", "of", "C0022635#ent", "<e1>", "with", "cisplatin", "normalized", "C3814418#ent", "<e2>", "and", "-alpha", "activity", ",", "and", "elevated", "the", "cisplatin-induced", "decrease", "of", "GSHpx", "activity", "and", "GSH", "."], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3814418", "name": "C3814418#ent", "pos": [8, 9]}}
{"token": ["GH", "C0037036#ent", "<e1>", "results", "in", "C0175695#ent", "<e2>", "or", "acromegaly", ",", "a", "condition", "associated", "with", "significant", "morbidity", "and", "mortality", ",", "while", "GH", "deficiency", "results", "in", "growth", "retardation", "children", "and", "the", "GH", "deficiency", "syndrome", "adults", "."], "h": {"id": "C0037036", "name": "C0037036#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0175695", "name": "C0175695#ent", "pos": [5, 6]}}
{"token": ["To", "compare", "the", "efficacy", "of", "nuclear", "microarray", "with", "fluorescence", "in", "situ", "hybridization", "C3274826#ent", "<e1>", ")", "and", "immunohistochemistry", "in", "detecting", "C1704943#ent", "<e2>", "gene", "translocation", "C1704943#ent", "<e2>", "fusion", "protein", "anaplastic", "large", "cell", "lymphoma", "ALCL", ")", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704943", "name": "C1704943#ent", "pos": [19, 20]}}
{"token": ["Fluorescence", "in", "situ", "hybridization", "C3274826#ent", "<e1>", ")", "analysis", "using", "the", "C1704943#ent", "<e2>", "break-apart", "probe", "C1704943#ent", "<e2>", "gene", "rearrangements", "all", "three", "patients", ",", "with", "a", "5'-ALK", "gene", "deletion", "in", "one", "patient", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704943", "name": "C1704943#ent", "pos": [10, 11]}}
{"token": ["A", "single", "oral", "dose", "600", "mg", "C0008806#ent", "<e1>", "seems", "sufficient", "to", "cure", "uncomplicated", "C0018081#ent", "<e2>", "and", "warrants", "further", "investigation", "in", "more", "patients", "."], "h": {"id": "C0008806", "name": "C0008806#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [13, 14]}}
{"token": ["Clinical", "trials", "shown", "C0008806#ent", "<e1>", "to", "be", "effective", "for", "the", "treatment", "of", "C0018081#ent", "<e2>", ",", "cystitis", ",", "complicated", "urinary-tract", "infections", "and", "skin", "and", "skin", "structure", "infections"], "h": {"id": "C0008806", "name": "C0008806#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [12, 13]}}
{"token": ["As", "well", "as", "causing", "C0027765#ent", "<e1>", "Herpes", "viruses", "associated", "with", "relapsing", "--", "remitting", "(", "C0008049#ent", "<e2>", "--", "Zoster", ",", "Epstein-Barr", ")", "and", "chronic", "(", "Rasmussen", "encephalitis", "disease", "processes", "(", "1", ")", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008049", "name": "C0008049#ent", "pos": [14, 15]}}
{"token": ["The", "reconstituted", "enzyme", "had", "C0059946#ent", "<e1>", "decatenation", "activity", ",", "which", "is", "the", "main", "catalytic", "activity", "C1336767#ent", "<e2>", "and", "relaxing", "activities", "but", "had", "no", "supercoiling", "activity"], "h": {"id": "C0059946", "name": "C0059946#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [15, 16]}}
{"token": ["Optimal", "incubation", "conditions", "were", "noted", "as", "pH", "8.0", "and", "30", "degrees", "C.", "Degradation", "enhanced", "for", "C1418251#ent", "<e1>", "by", "the", "addition", "of", "C0000979#ent", "<e2>", ",", "lactate", ",", "or", "pyruvate", "."], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [21, 22]}}
{"token": ["The", "anaerobic", "degradation", "of", "C1418251#ent", "<e1>", "was", "enhanced", "by", "the", "addition", "of", "C0000979#ent", "<e2>", ",", "lactate", ",", "pyruvate", ",", "sodium", "chloride", "cellulose", ",", "or", "zero-valent", "iron", "."], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [12, 13]}}
{"token": ["C0006644#ent", "<e1>", "was", "used", "as", "internal", "standard", "C1421567#ent", "<e2>", ")", "."], "h": {"id": "C0006644", "name": "C0006644#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421567", "name": "C1421567#ent", "pos": [7, 8]}}
{"token": ["A", "passing", "histamine-like", "effect", "of", "C0010206#ent", "<e1>", "and", "other", "benzopyrones", "is", "an", "indirect", "C0304402#ent", "<e2>", "for", "the", "RES", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [13, 14]}}
{"token": ["It", "is", "believed", "that", "C0010206#ent", "<e1>", "belongs", "to", "a", "group", "of", "reticulo-endothelial", "system", "C0304402#ent", "<e2>", "which", "increase", "the", "numbers", "of", "phagocytosing", "sites", "by", "increasing", "the", "number", "of", "phagocytic", "cells"], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [13, 14]}}
{"token": ["Lipolysis", "in", "young", "and", "adult", "chicken", "adipose", "tissue", "stimulated", "by", "epinephrine", ",", "isoproterenol", ",", "phenylephrine", ",", "dobutamine", "and", "C0029193#ent", "<e1>", ",", "but", "was", "inhibited", "by", "C0009014#ent", "<e2>", "and", "para-aminoclonidine", "."], "h": {"id": "C0029193", "name": "C0029193#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [25, 26]}}
{"token": ["C0206138#ent", "<e1>", "been", "described", "as", "a", "form", "of", "progressive", "C0036421#ent", "<e2>", "which", "there", "is", "relatively", "limited", "involvement", "of", "the", "skin", ",", "prominence", "of", "calcinosis", ",", "Raynaud's", "phenomenon", ",", "esophageal", "dysfunction", "telangiectasia", "."], "h": {"id": "C0206138", "name": "C0206138#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "dominant", "negative", "mutants", "of", "the", "SAPK-specific", "activator", ",", "C1434639#ent", "<e1>", ",", "induced", "a", "further", "increase", "in", "EGF-induced", "C1413855#ent", "<e2>", "promoter", "activity"], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413855", "name": "C1413855#ent", "pos": [20, 21]}}
{"token": ["Characteristics", "of", "the", "autophosphorylation", "of", "Ca2+/calmodulin-dependent", "protein", "kinase", "II", "C0054521#ent", "<e1>", "from", "the", "cytosol", "and", "in", "the", "postsynaptic", "densities", "C1418591#ent", "<e2>", ")", "of", "rat", "brain", "were", "investigated", "."], "h": {"id": "C0054521", "name": "C0054521#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418591", "name": "C1418591#ent", "pos": [19, 20]}}
{"token": ["C1826313#ent", "<e1>", "enhances", "the", "pathogenicity", "and", "accelerates", "the", "course", "of", "C0343755#ent", "<e2>", ",", "furthermore", ",", "infection", "with", "HIV-1", "increases", "the", "risk", "of", "reactivation", "or", "reinfection", "with", "C1826313#ent", "<e1>", "."], "h": {"id": "C1826313", "name": "C1826313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0343755", "name": "C0343755#ent", "pos": [10, 11]}}
{"token": ["We", "measured", "creatine", "kinase", "C0010287#ent", "<e1>", ",", "C3714613#ent", "<e2>", ",", "CK-MB", "isoenzyme", "activity", "mass", "concentration", "and", "distribution", "of", "C0010287#ent", "<e1>", "isoenzymes", "(", "by", "electrophoresis", ")", "in", "serum", "from", "five", "members", "of", "one", "family", "."], "h": {"id": "C3714613", "name": "C3714613#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010287", "name": "C0010287#ent", "pos": [4, 5]}}
{"token": ["Evidence", "of", "abnormal", "creatine", "metabolism", "rats", "fed", "beta-GPA", "included", ":", "excessive", "creatinuria", ",", "reduction", "in", "urine", "creatinine", "reduced", "levels", "of", "muscle", "and", "C3714613#ent", "<e1>", "and", "a", "reduced", "activity", "of", "C0010287#ent", "<e2>"], "h": {"id": "C3714613", "name": "C3714613#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0010287", "name": "C0010287#ent", "pos": [29, 30]}}
{"token": ["Creatine", "kinase", "CK", ";", "C3714613#ent", "<e1>", "catalyzes", "the", "reversible", "conversion", "of", "creatine", "and", "MgATP", "to", "C0010287#ent", "<e2>", "and", "MgADP", "."], "h": {"id": "C3714613", "name": "C3714613#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010287", "name": "C0010287#ent", "pos": [15, 16]}}
{"token": ["C0002874#ent", "<e1>", "association", "with", "intracerebral", "calcifications", "been", "described", "in", "patients", "with", "C1414056#ent", "<e2>", "Revesz", "syndrome", ",", "but", "not", "so", "far", "in", "confirmed", "cases", "of", "Fanconi", "anaemia"], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414056", "name": "C1414056#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "we", "show", "that", "these", "mGluR-dependent", "changes", "in", "C1333226#ent", "<e1>", "expression", "are", "lost", "in", "neurons", "derived", "from", "C2700049#ent", "<e2>", "knockout", "mice", "a", "model", "of", "FXS", "."], "h": {"id": "C1333226", "name": "C1333226#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2700049", "name": "C2700049#ent", "pos": [18, 19]}}
{"token": ["Computational", "target", "gene", "prediction", "that", "both", "miR-133a", "and", "C2825947#ent", "<e1>", "are", "targeting", "transcript", "of", "C0079782#ent", "<e2>", "PKM2", ")", ",", "a", "potential", "oncogene", "in", "solid", "cancers"], "h": {"id": "C2825947", "name": "C2825947#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079782", "name": "C0079782#ent", "pos": [14, 15]}}
{"token": ["Baclofen", "reduced", "both", "the", "disappearance", "of", "DA", "after", "C0051427#ent", "<e1>", "and", "the", "acceleration", "of", "the", "DA", "disappearance", "caused", "by", "C0040615#ent", "<e2>", "in", "corpus", "striatum", "in", "the", "mesolimbic", "area", "."], "h": {"id": "C0051427", "name": "C0051427#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [19, 20]}}
{"token": ["The", "most", "common", "inherited", "bleeding", "disorders", "women", "are", "C0042974#ent", "<e1>", "vWD", ")", ",", "carriership", "of", "hemophilia", "A", "B", ",", "and", "C1414498#ent", "<e2>", "FXI", ")", "deficiency", "."], "h": {"id": "C0042974", "name": "C0042974#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414498", "name": "C1414498#ent", "pos": [20, 21]}}
{"token": ["C1875400#ent", "<e1>", "of", "AG-13", "did", "not", "anastomose", "with", "tester", "isolates", "of", "C1335222#ent", "<e2>", "through", "AG-12", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335222", "name": "C1335222#ent", "pos": [11, 12]}}
{"token": ["The", "typing", "methods", "designed", "to", "group", "C1875400#ent", "<e1>", "into", "the", "dimorphic", "allelic", "families", "FC27", "and", "C1335222#ent", "<e2>", "and", "to", "detect", "possible", "between-family", "recombination", "events", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335222", "name": "C1335222#ent", "pos": [15, 16]}}
{"token": ["We", "diagnosed", "a", "22-year-old", "man", "with", "psychomotor", "retardation", "rare", "seizures", ",", "hyperglycinemia", ",", "and", "C0543541#ent", "<e1>", "as", "an", "atypical", "variant", "of", "C0751748#ent", "<e2>", "NKH", ")", "."], "h": {"id": "C0543541", "name": "C0543541#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0751748", "name": "C0751748#ent", "pos": [21, 22]}}
{"token": ["We", "diagnosed", "a", "22-year-old", "man", "with", "psychomotor", "retardation", "rare", "seizures", ",", "hyperglycinemia", ",", "and", "C0543541#ent", "<e1>", "as", "an", "atypical", "variant", "of", "nonketotic", "hyperglycinemia", "C0751748#ent", "<e2>", ")", "."], "h": {"id": "C0543541", "name": "C0543541#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0751748", "name": "C0751748#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "the", "occurrence", "of", "CPM", "and", "C0426970#ent", "<e1>", "in", "a", "patient", "who", "experienced", "fluoroquinolone-associated", "severe", "C0020616#ent", "<e2>", "."], "h": {"id": "C0426970", "name": "C0426970#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [16, 17]}}
{"token": ["The", "B-box", "region", "of", "C0023524#ent", "<e1>", "is", "retained", "in", "the", "C0297323#ent", "<e2>", "(", "retinoic", "acid", "receptor", "alpha", "fusion", "protein", "generated", "by", "the", "t(15;17)", "translocation", "characteristic", "of", "acute", "promyelocytic", "leukemia", "APL", ")", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0297323", "name": "C0297323#ent", "pos": [10, 11]}}
{"token": ["The", "coiled-coil", "domain", "C0023524#ent", "<e1>", "is", "responsible", "for", "the", "aberrant", "dynamics", "of", "C0297323#ent", "<e2>", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0297323", "name": "C0297323#ent", "pos": [12, 13]}}
{"token": ["Oxidized", "dextran", "was", "reacted", "by", "reductive", "amination", "with", "C0031957#ent", "<e1>", "to", "obtain", "C0058758#ent", "<e2>", ",", "the", "resulted", "polycation", "was", "then", "incubated", "with", "plasmid", "pEGFP", "to", "form", "polyplexes", "by", "electrostatic", "interactions"], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0058758", "name": "C0058758#ent", "pos": [12, 13]}}
{"token": ["Although", "acid", "charcoal", "extraction", "or", "lectin", "affinity", "chromatography", "not", "remove", "activity", ",", "C1415790#ent", "<e1>", "activity", "was", "eliminated", "by", "C0030909#ent", "<e2>", "."], "h": {"id": "C1415790", "name": "C1415790#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030909", "name": "C0030909#ent", "pos": [18, 19]}}
{"token": ["No", "cross-reactivity", "was", "observed", "with", "sera", "from", "patients", "with", "C0038013#ent", "<e1>", "filariasis", ",", "amebiasis", ",", "C0036329#ent", "<e2>", ",", "dengue", ",", "scrub", "typhus", "leptospirosis", ",", "or", "toxoplasmosis", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036329", "name": "C0036329#ent", "pos": [15, 16]}}
{"token": ["No", "cross-reactivity", "was", "noted", "with", "sera", "from", "patients", "with", "C0038013#ent", "<e1>", "filariasis", ",", "amebiasis", ",", "C0036329#ent", "<e2>", ",", "dengue", ",", "scrub", "typhus", "leptospirosis", ",", "or", "toxoplasmosis", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036329", "name": "C0036329#ent", "pos": [15, 16]}}
{"token": ["Mitochondrial", "dysfunction", "appeared", "to", "be", "involved", "in", "the", "process", "because", "a", "disruption", "of", "mitochondrial", "transmembrane", "potential", "with", "the", "activation", "of", "C1705066#ent", "<e1>", "was", "demonstrated", "in", "C0812246#ent", "<e2>", "and", "IFN-gamma-stimulated", "HSG", "cells"], "h": {"id": "C1705066", "name": "C1705066#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [25, 26]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "the", "effects", "of", "different", "C0012262#ent", "<e1>", "in", "comparison", "with", "phorbol", "12-myristate", "13-acetate", "PMA", ")", "on", "eicosanoid-independent", "phospholipase", "A2", "C0031667#ent", "<e2>", ")", "activation", "in", "human", "platelets", "and", "neutrophils", "."], "h": {"id": "C0012262", "name": "C0012262#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [25, 26]}}
{"token": ["Tumor", "necrosis", "factor-alpha", "C1710304#ent", "<e1>", ")", "is", "a", "key", "pathogenic", "component", "of", "C0038362#ent", "<e2>"], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038362", "name": "C0038362#ent", "pos": [12, 13]}}
{"token": ["The", "results", "of", "spin", "lattice", "relaxation", "time", "of", "DEO6", "suggest", "that", "all", "the", "C0054666#ent", "<e1>", "of", "the", "ethylene", "oxides", "C2350558#ent", "<e2>", "by", "the", "coordination", "to", "the", "metal", "ion"], "h": {"id": "C0054666", "name": "C0054666#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [19, 20]}}
{"token": ["C0343401#ent", "<e1>", "increasingly", "isolated", "from", "C0206172#ent", "<e2>", "and", "may", "be", "associated", "with", "adverse", "prognosis", "."], "h": {"id": "C0343401", "name": "C0343401#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0206172", "name": "C0206172#ent", "pos": [5, 6]}}
{"token": ["Low", "C1333237#ent", "<e1>", "capacity", "and", "C1738886#ent", "<e2>", "and", "NAT2", "variants", "associated", "with", "reduced", "detoxification", "ability", "increase", "susceptibility", "to", "such", "damage", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1738886", "name": "C1738886#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "androgen-dependent", "transcriptional", "suppression", "of", "the", "C0033713#ent", "<e1>", "strongly", "counteracted", "by", "C0010621#ent", "<e2>"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010621", "name": "C0010621#ent", "pos": [13, 14]}}
{"token": ["Kinetic", "analyses", "a", "k(cat)/K(m", ")", "value", "of", "1,808", "s(-1", ")", "m(-1", ")", "for", "C2001899#ent", "<e1>", "hydrolysis", "of", "alpha1(I)772", "-", "786", "C1705396#ent", "<e2>", ",", "approximately", "10-fold", "lower", "than", "for", "type", "I", "collagen"], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705396", "name": "C1705396#ent", "pos": [20, 21]}}
{"token": ["C0171023#ent", "<e1>", ",", "risperidone", ",", "and", "haloperidol", "were", "the", "most", "common", "C0033978#ent", "<e2>", "before", "entry", "."], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [11, 12]}}
{"token": ["These", "results", "show", "that", "the", "\"", "C0409974#ent", "<e1>", "anticoagulant", "\"", "is", "a", "frequent", "coagulation", "abnormality", "when", "C0021053#ent", "<e2>", "absent", "."], "h": {"id": "C0409974", "name": "C0409974#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [16, 17]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "characterize", "placental", "expression", "of", "the", "C0033551#ent", "<e1>", "cyclooxygenase", "(", "COX", ")", "-1", "and", "-2", "and", "prostaglandin", "dehydrogenase", "C3274756#ent", "<e2>", ",", "a", "degrading", "enzyme", ")", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3274756", "name": "C3274756#ent", "pos": [24, 25]}}
{"token": ["The", "Stop", "Asthma", "Clinical", "System", "(", "C1419804#ent", "<e1>", ")", "is", "a", "C1848296#ent", "<e2>", "designed", "for", "this", "purpose", "."], "h": {"id": "C1419804", "name": "C1419804#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1848296", "name": "C1848296#ent", "pos": [11, 12]}}
{"token": ["Mefloquine", "is", "the", "main", "C3536844#ent", "<e1>", "used", "for", "treatment", "of", "falciparum", "C0024530#ent", "<e2>", "patients", "at", "the", "C0024530#ent", "<e2>", "clinics", "in", "Thailand", "."], "h": {"id": "C3536844", "name": "C3536844#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}}
{"token": ["Artemether", "has", "the", "potential", "to", "be", "an", "alternative", "C3536844#ent", "<e1>", "for", "multiple", "drug", "resistant", "falciparum", "C0024530#ent", "<e2>", "."], "h": {"id": "C3536844", "name": "C3536844#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [15, 16]}}
{"token": ["During", "in", "vitro", "studies", ",", "1", "mmol/L", "C0050337#ent", "<e1>", "had", "no", "effect", "on", "C0937932#ent", "<e2>", "activity", "and", "0.2", "mmol/L", "C0050337#ent", "<e1>", "did", "not", "inhibit", "xanthine", "dehydrogenase", "activity", "."], "h": {"id": "C0050337", "name": "C0050337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0937932", "name": "C0937932#ent", "pos": [13, 14]}}
{"token": ["An", "amino", "acid", "sequence", "of", "42", "%", "was", "found", "between", "the", "mature", "protein", "region", "C1824644#ent", "<e1>", "and", "that", "of", "C1826608#ent", "<e2>", "."], "h": {"id": "C1824644", "name": "C1824644#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1826608", "name": "C1826608#ent", "pos": [19, 20]}}
{"token": ["Over-the-counter", "stimulants", "phenylpropanolamine", "hydrochloride", "C0033798#ent", "<e1>", ",", "pseudoephedrine", ",", "caffeine", ")", "are", "used", "widely", "as", "C0282374#ent", "<e2>", ",", "anorectic", "agents", "amphetamine", "substitutes", "and", "\"", "legal", "stimulants"], "h": {"id": "C0033798", "name": "C0033798#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282374", "name": "C0282374#ent", "pos": [15, 16]}}
{"token": ["C0033798#ent", "<e1>", "is", "related", "to", "phenylpropanolamine", ",", "a", "C0282374#ent", "<e2>", "removed", "from", "the", "market", "place", "due", "to", "concerns", "that", "its", "use", "increased", "the", "risk", "of", "hemorrhagic", "stroke"], "h": {"id": "C0033798", "name": "C0033798#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282374", "name": "C0282374#ent", "pos": [8, 9]}}
{"token": ["The", "treatments", "compared", "were", "C0033798#ent", "<e1>", "nose", "drops", ",", "an", "oral", "antihistamine", "C0282374#ent", "<e2>", "(", "Dimotapp", ")", "and", "autoinflation", "of", "the", "middle", "ear"], "h": {"id": "C0033798", "name": "C0033798#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282374", "name": "C0282374#ent", "pos": [12, 13]}}
{"token": ["Newly", "developed", ",", "simple", ",", "low-cost", "and", "sensitive", "ion-selective", "electrodes", "been", "proposed", "for", "determination", "of", "some", "C0003299#ent", "<e1>", "as", "lamotrigine", ",", "felbamate", ",", "and", "C0033148#ent", "<e2>", "in", "their", "pharmaceutical", "preparations", "well", "as", "in", "biological", "fluids"], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [16, 17]}, "relation": "therapeutic_class_of", "t": {"id": "C0033148", "name": "C0033148#ent", "pos": [24, 25]}}
{"token": ["C0018801#ent", "<e1>", "shown", "that", "C0019927#ent", "<e2>", "including", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitors", "and", "beta-adrenergic", "receptor", "blockers", "beta", "blockers", ",", "reduce", "remodeling", "in", "parallel", "with", "improved", "clinical", "outcomes"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019927", "name": "C0019927#ent", "pos": [4, 5]}}
{"token": ["C1414997#ent", "<e1>", "increased", "the", "wet", "and", "dry", "weight", "lungs", "and", "induced", "increased", "C0009325#ent", "<e2>", "formation", "and", "a", "non-reversible", "fibrotic", "reaction", "in", "the", "lungs", "."], "h": {"id": "C1414997", "name": "C1414997#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [12, 13]}}
{"token": ["Enterobacter", "bacteremia", "occurs", "in", "patients", "with", "long-standing", "underlying", "C0221423#ent", "<e1>", "who", "received", "antimicrobial", "agents", "their", "C0004610#ent", "<e2>", "."], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [15, 16]}}
{"token": ["The", "prognosis", "of", "the", "underlying", "disease", ",", "C0221423#ent", "<e1>", "foci", "location", ",", "initial", "clinical", "status", "C0004610#ent", "<e2>", "complications", ",", "and", "the", "type", "of", "antibiotic", "treatment", "analyzed", "."], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [15, 16]}}
{"token": ["Glucuronidation", "of", "xenobiotics", "and", "endobiotics", "is", "catalyzed", "by", "a", "group", "of", "C0021699#ent", "<e1>", "the", "endoplasmic", "reticulum", "of", "cells", "the", "C1259497#ent", "<e2>", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [11, 12]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C1259497", "name": "C1259497#ent", "pos": [19, 20]}}
{"token": ["Synovial", "osteochondromatosis", "by", "C0027743#ent", "<e1>", "been", "rarely", "reported", ",", "usually", "with", "C1142146#ent", "<e2>", "the", "elbow", "."], "h": {"id": "C0027743", "name": "C0027743#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1142146", "name": "C1142146#ent", "pos": [11, 12]}}
{"token": ["A", "second", "patient", "without", "clinical", "findings", "C0010481#ent", "<e1>", "had", "normal", "C0038317#ent", "<e2>", "levels", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [10, 11]}}
{"token": ["Kaolin", "clotting", "time", "KCT", ")", "of", "patient", "plasma", "PP", ")", "and", "a", "mixture", "of", "PP/normal", "plasma", "(", "C1706141#ent", "<e1>", ")", "detected", "the", "lupus", "anticoagulant", "C1420423#ent", "<e2>", ")", "."], "h": {"id": "C1706141", "name": "C1706141#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [24, 25]}}
{"token": ["The", "C0029166#ent", "<e1>", "indicative", ",", "the", "signs", "of", "this", "C0035435#ent", "<e2>", "described", ",", "as", "well", "as", "the", "characteristics", "of", "the", "other", "disorders", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [9, 10]}}
{"token": ["The", "C0029166#ent", "<e1>", "bacterial", "endocarditis", "mimic", "other", "C0035435#ent", "<e2>", "disguise", "the", "underlying", "disease", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [7, 8]}}
{"token": ["The", "C2936886#ent", "<e1>", ",", "as", "well", "as", "the", "secretory", "responses", "the", "C0127400#ent", "<e2>", "largely", "dependent", "on", "the", "presence", "of", "extracellular", "C2936886#ent", "<e1>", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [11, 12]}}
{"token": ["Extracellular", "C2936886#ent", "<e1>", "as", "well", "as", "the", "C0127400#ent", "<e2>", "noradrenaline", "and", "probably", "also", "prostaglandins", "are", "involved", "in", "the", "signal", "chain"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [7, 8]}}
{"token": ["With", "the", "exception", "of", "two", "mutations", "that", "impair", "signal", "peptide", "cleavage", "during", "alpha1(X", ")", "chain", "biosynthesis", "C2748503#ent", "<e1>", "mutations", "are", "clustered", "within", "the", "C1416809#ent", "<e2>"], "h": {"id": "C2748503", "name": "C2748503#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416809", "name": "C1416809#ent", "pos": [23, 24]}}
{"token": ["A", "69-year-old", "patient", "with", "non-small", "cell", "lung", "cancer", "pneumonitis", "with", "the", "use", "of", "the", "C0003392#ent", "<e1>", "gemcitabine", ",", "paclitaxel", ",", "and", "C0377401#ent", "<e2>", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0377401", "name": "C0377401#ent", "pos": [21, 22]}}
{"token": ["The", "C0003392#ent", "<e1>", "capecitabine", "and", "C0377401#ent", "<e2>", "seems", "to", "be", "comparable", ",", "but", "the", "toxicity", "profiles", "are", "different", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0377401", "name": "C0377401#ent", "pos": [5, 6]}}
{"token": ["Other", "possibilities", "are", "to", "incorporate", "the", "new", "C0003392#ent", "<e1>", "taxanes", ",", "Gemcitabine", ",", "C0377401#ent", "<e2>", ",", "Irinotecan", ")", "into", "the", "chemotherapeutic", "regimens"], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0377401", "name": "C0377401#ent", "pos": [13, 14]}}
{"token": ["Currently", ",", "patients", "who", "progress", "after", "trastuzumab-based", "therapy", "are", "often", "maintained", "on", "trastuzumab", "combined", "with", "a", "different", "C0003392#ent", "<e1>", "such", "as", "C0377401#ent", "<e2>", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0377401", "name": "C0377401#ent", "pos": [21, 22]}}
{"token": ["Calcium", "channel", "blockers", "C0006684#ent", "<e1>", ")", "can", "influence", "the", "production", "of", "several", "C0623362#ent", "<e2>", ",", "but", "no", "study", ",", "so", "far", ",", "has", "assessed", "the", "association", "between", "use", "of", "C0006684#ent", "<e1>", "and", "PAPP-A", "levels", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [12, 13]}}
{"token": ["A", "patient", "with", "Gorham's", "disease", "massive", "osteolysis", "disappearing", "C0005940#ent", "<e1>", "of", "the", "right", "clavicle", "C0032227#ent", "<e2>"], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032227", "name": "C0032227#ent", "pos": [14, 15]}}
{"token": ["In", "summary", ",", "C0079083#ent", "<e1>", "can", "be", "given", "to", "patients", "with", "severe", "C1565489#ent", "<e2>"], "h": {"id": "C0079083", "name": "C0079083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [12, 13]}}
{"token": ["One", "characteristic", "of", "a", "C0948052#ent", "<e1>", "its", "ability", "to", "react", "with", "C0086376#ent", "<e2>", "prior", "to", "the", "induction", "of", "skin", "sensitization"], "h": {"id": "C0948052", "name": "C0948052#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["This", "study", "investigates", "the", "effects", "of", "C0037533#ent", "<e1>", "regional", "vascular", "capacitance", "eight", "patients", "with", "severe", "C0018802#ent", "<e2>", "New", "York", "Heart", "Association", "class", "IV", "and", "pulmonary", "hypertension"], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["In", "mesenteric", "arteries", "responses", "to", "noradrenaline", ",", "acetylcholine", "and", "C0037533#ent", "<e1>", "not", "different", "between", "C0018802#ent", "<e2>", "sham", "rats", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "CHIP", "is", "a", "C0077678#ent", "<e1>", "four-repeat", "tau", "and", "maintains", "C1420257#ent", "<e2>", "regulating", "the", "quality", "control", "tau", "in", "neurons", "."], "h": {"id": "C0077678", "name": "C0077678#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [11, 12]}}
{"token": ["We", "found", "that", "all", "classes", "of", "ubiquitin", "genes", "well", "as", "the", "two", "C1417679#ent", "<e1>", "encoding", "the", "ribosomal", "proteins", "S17", "C1419657#ent", "<e2>", "were", "expressed", "at", "abnormally", "high", "levels", "in", "various", "hematopoietic", "malignant", "tumor", "cells"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419657", "name": "C1419657#ent", "pos": [19, 20]}}
{"token": ["The", "crystallization", "of", "zeolite", "Beta", "from", "C1415495#ent", "<e1>", "at", "150", "degrees", "C", "in", "the", "presence", "of", "C0076252#ent", "<e2>", "monitored", "by", "XRD", ",", "FTIR", "and", "(29)Si", "MAS", "NMR", "techniques", "."], "h": {"id": "C1415495", "name": "C1415495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0076252", "name": "C0076252#ent", "pos": [16, 17]}}
{"token": ["They", "were", "compared", "with", "two", "control", "groups", "50", "patients", "with", "C0008677#ent", "<e1>", "emphysema", "and", "33", "patients", "with", "C0004096#ent", "<e2>"], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}}
{"token": ["Seven", "healthy", "subjects", "seven", "clinically", "stable", "patients", "with", "C0008677#ent", "<e1>", "seven", "clinically", "stable", "C0004096#ent", "<e2>", "patients", "were", "studied", "during", "quiet", "breathing", "."], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}}
{"token": ["The", "renal", "failure", "patient", "1", "due", "to", "C3495801#ent", "<e1>", "but", "whether", "the", "constrictive", "pericarditis", "due", "to", "C0031046#ent", "<e2>", "the", "pericarditis", "of", "C3495801#ent", "<e1>", "uncertain", "."], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031046", "name": "C0031046#ent", "pos": [16, 17]}}
{"token": ["The", "inhibitor", "of", "apoptosis", "(", "iap", ")", "proteins", "belong", "to", "a", "C1517488#ent", "<e1>", "protect", "certain", "cell", "to", "undergo", "C1418401#ent", "<e2>", "response", "to", "a", "variety", "of", "stimuli", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "potassium", "channel", "encoded", "by", "the", "human", "C1425833#ent", "<e1>", "HERG", ")", "have", "been", "linked", "to", "the", "C0023976#ent", "<e2>", "LQTS", ")", ",", "a", "cardiac", "disease", "associated", "with", "increased", "preponderance", "of", "ventricular", "arrhythmias", "sudden", "death"], "h": {"id": "C1425833", "name": "C1425833#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023976", "name": "C0023976#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "human", "C1425833#ent", "<e1>", "HERG", ")", "cause", "C0023976#ent", "<e2>", "LQT2", ")", "."], "h": {"id": "C1425833", "name": "C1425833#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023976", "name": "C0023976#ent", "pos": [9, 10]}}
{"token": ["Mice", "deficient", "in", "the", "C1413230#ent", "<e1>", "mCd59a-/-", ")", "were", "used", "to", "investigate", "the", "role", "of", "C1504686#ent", "<e2>", "in", "experimentally", "induced", "accelerated", "nephrotoxic", "nephritis", "a", "model", "of", "immune", "complex-mediated", "glomerulonephritis"], "h": {"id": "C1413230", "name": "C1413230#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1504686", "name": "C1504686#ent", "pos": [15, 16]}}
{"token": ["The", "C1413230#ent", "<e1>", "11p13.5", "and", "the", "C1504686#ent", "<e2>", "encoded", "by", "it", "are", "the", "principal", "markers", "used", "in", "our", "mutagenesis", "studies", "."], "h": {"id": "C1413230", "name": "C1413230#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1504686", "name": "C1504686#ent", "pos": [6, 7]}}
{"token": ["The", "obtained", "data", "were", "correlated", "to", "corresponding", "serum", "or", "plasma", "levels", "C0520680#ent", "<e1>", ",", "human", "leukocyte", "elastase", "(", "C1414369#ent", "<e2>", ")", "and", "neopterin", "."], "h": {"id": "C0520680", "name": "C0520680#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414369", "name": "C1414369#ent", "pos": [18, 19]}}
{"token": ["The", "C0019917#ent", "<e1>", "increased", "with", "increasing", "C2926735#ent", "<e2>", "of", "the", "photoperiod", "."], "h": {"id": "C0019917", "name": "C0019917#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [6, 7]}}
{"token": ["Glucagon", "and", "C3887648#ent", "<e1>", "responses", "to", "hypoglycemia", "were", "not", "affected", "by", "C0011849#ent", "<e2>", "or", "insulin", "treatment"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}}
{"token": ["We", "speculate", "that", "reduction", "of", "the", "potentiating", "effects", "of", "ACh", "and", "C3887648#ent", "<e1>", "lessens", "glucose", "sensitivity", "islet", "beta", "alpha", "cells", "this", "rat", "model", "of", "C0011849#ent", "<e2>", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [24, 25]}}
{"token": ["Serum", "concentration", "of", "C0010977#ent", "<e1>", "and", "its", "active", "metabolite", "5-hydroxydantrolene", "were", "determined", "in", "27", "C0007789#ent", "<e2>", "patients", "."], "h": {"id": "C0010977", "name": "C0010977#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [14, 15]}}
{"token": ["Because", "only", "LECs", "expressed", "progesterone", "receptors", "PRs", ")", ",", "we", "investigated", "the", "role", "of", "receptor", "activator", "of", "nuclear", "factor-kappaB", "ligand", "RANKL", ")", ",", "a", "C0965793#ent", "<e1>", "in", "mediating", "increased", "C3274839#ent", "<e2>", "proliferation", "."], "h": {"id": "C0965793", "name": "C0965793#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C3274839", "name": "C3274839#ent", "pos": [29, 30]}}
{"token": ["It", "has", "the", "potential", "to", "be", "used", "for", "the", "treatment", "of", "the", "GSL", "C0085078#ent", "<e1>", "is", "currently", "in", "clinical", "trials", "the", "treatment", "of", "C1961835#ent", "<e2>"], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [23, 24]}}
{"token": ["Mutations", "of", "the", "human", "C1420193#ent", "<e1>", "erythroid", "and", "kidney", "isoforms", "anion", "exchanger", "1", "C3538902#ent", "<e2>", ",", "band", "3", "result", "in", "erythrocyte", "abnormalities", "distal", "renal", "tubular", "acidosis", "dRTA", ")", "and", "such", "mutations", "are", "observed", "in", "Southeast", "Asia", "where", "hemoglobinopathies", "are", "prevalent", "."], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538902", "name": "C3538902#ent", "pos": [13, 14]}}
{"token": ["Diabetes", ",", "a", "serious", "complication", "of", "C1858664#ent", "<e1>", ",", "is", "frequently", "associated", "with", "C0023890#ent", "<e2>", "which", "reduces", "life", "expectancy"], "h": {"id": "C1858664", "name": "C1858664#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [13, 14]}}
{"token": ["The", "prognosis", "of", "C1858664#ent", "<e1>", "is", "normal", "when", "phlebotomy", "therapy", "started", "prior", "to", "manifestation", "of", "C0023890#ent", "<e2>", "or", "diabetes", "."], "h": {"id": "C1858664", "name": "C1858664#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [15, 16]}}
{"token": ["This", "paper", "offers", "a", "quantitative", "evaluation", "of", "the", "scientific", "information", "in", "Brazil", "on", "several", "endemic", "diseases", "C0041234#ent", "<e1>", "schistosomiasis", ",", "leishmaniasis", ",", "C0023343#ent", "<e2>", ",", "malaria", "and", "filariasis", "."], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [22, 23]}}
{"token": ["Delta-crystallin", ",", "the", "major", "soluble", "protein", "component", "avian", "and", "reptilian", "eye", "lenses", ",", "is", "highly", "C1334043#ent", "<e1>", "to", "the", "urea", "cycle", "enzyme", "C1412582#ent", "<e2>", "ASL", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412582", "name": "C1412582#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "the", "anteromedial", "(", "AM", ")", "and", "lateral", "dorsal", "(", "LD", ")", "nuclei", "project", "to", "C1842325#ent", "<e1>", "and", "more", "lightly", "to", "C1412999#ent", "<e2>", "."], "h": {"id": "C1842325", "name": "C1842325#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [23, 24]}}
{"token": ["By", "using", "quantitative", "real-time", "PCR", "expression", "of", "C4082365#ent", "<e1>", "ChAT", ")", ",", "a", "critical", "C0014442#ent", "<e2>", "for", "ACh", "synthesis", ",", "was", "identified", "in", "H508", ",", "WiDr", ",", "and", "Caco-2", "colon", "cancer", "cells"], "h": {"id": "C4082365", "name": "C4082365#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["Guinea", "pig", "antiserum", "specific", "for", "purified", "C4082365#ent", "<e1>", "been", "shown", "to", "cross-react", "with", "rabbit", "C0014442#ent", "<e2>", "."], "h": {"id": "C4082365", "name": "C4082365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["Ultrastructural", "alterations", "(", "lysosomes", ",", "mitochondrial", "damage", "were", "found", "predominantly", "in", "the", "C2350558#ent", "<e1>", "muscles", ",", "but", "rarely", "with", "C0028066#ent", "<e2>", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [19, 20]}}
{"token": ["Therefore", "a", "calcium", "channel", "blocker", "C0028066#ent", "<e1>", ")", "was", "administered", "to", "mice", "C2350558#ent", "<e2>", "for", "four", "days", ",", "and", "their", "soleus", "muscle", "investigated", "comparatively", "to", "C2350558#ent", "<e2>", "animals", "without", "C0028066#ent", "<e1>", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [5, 6]}}
{"token": ["Moreover", ",", "other", "RHO", "proteins", "such", "as", "RHOB", ",", "RHOD", ",", "and", "their", "effectors", "(", "DIAPH1", "and", "DIAPH2", ")", ",", "may", "modulate", "PKN1/", "C1335632#ent", "<e1>", "signaling", "to", "effect", "changes", "in", "myosin", "phosphatase", "activity", "C0067062#ent", "<e2>"], "h": {"id": "C1335632", "name": "C1335632#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0067062", "name": "C0067062#ent", "pos": [33, 34]}}
{"token": ["The", "transcription", "factors", "NF-kappaB", "and", "AP-1", "can", "be", "activated", ",", "and", "then", "directly", "transactivate", "C1539478#ent", "<e1>", "in", "response", "to", "C0003392#ent", "<e2>"], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [19, 20]}}
{"token": ["These", "data", "show", "specific", "involvement", "of", "the", "C1539478#ent", "<e1>", "the", "anti-cancer", "activity", "of", "resveratrol", "and", "highlight", "the", "C0003392#ent", "<e2>", "potential", "of", "this", "natural", "product", "in", "addition", "to", "its", "recently", "reported", "chemopreventive", "activity"], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [17, 18]}}
{"token": ["Twenty-eight", "patients", "with", "severe", "C0702166#ent", "<e1>", "and", "one", "with", "C0162836#ent", "<e2>", "C0702166#ent", "<e1>", "were", "treated", "for", "12", "to", "16", "weeks", "with", "a", "new", "synthetic", "retinoid", "isotretinoin", "(", "Roaccutane", ")", "."], "h": {"id": "C0702166", "name": "C0702166#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0162836", "name": "C0162836#ent", "pos": [9, 10]}}
{"token": ["Occasionally", ",", "C0702166#ent", "<e1>", "may", "occur", "together", "with", "C0162836#ent", "<e2>", "dissecting", "cellulitis", "the", "scalp", ",", "the", "so", "called", "\"", "follicular", "occlusion", "triad"], "h": {"id": "C0702166", "name": "C0702166#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0162836", "name": "C0162836#ent", "pos": [8, 9]}}
{"token": ["In", "synaptosomes", ",", "PKC", "activation", "but", "not", "C1366876#ent", "<e1>", "MAPK", "inhibition", "resulted", "in", "C1420214#ent", "<e2>", "redistribution", "from", "cholesterolrich", "lipid", "raft", "fractions", "to", "nonlipid", "raft", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420214", "name": "C1420214#ent", "pos": [13, 14]}}
{"token": ["The", "clonogenic", "potential", "of", "MCF-7", "cells", "tissue", "culture", "decreased", "by", "the", "expression", "of", "C1708015#ent", "<e1>", "and", "was", "additively", "suppressed", "by", "the", "chemotherapeutic", "agents", "C0015133#ent", "<e2>", "and", "5-fluorouracil", "in", "a", "dose", "and", "time", "dependent", "."], "h": {"id": "C1708015", "name": "C1708015#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [23, 24]}}
{"token": ["The", "C0079429#ent", "<e1>", "encoding", "the", "xenobiotic-metabolising", "microsomal", "enzyme", ",", "C1134446#ent", "<e2>", "mEPHX", ")", ",", "shows", "two", "common", "mutations", ",", "i.e.", "at", "exons", "3", "4", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [9, 10]}}
{"token": ["Chlamydophila", "pneumoniae", "an", "important", "respiratory", "pathogen", "lower", "C0035243#ent", "<e1>", "has", "also", "been", "implicated", "in", "C1956346#ent", "<e2>", "CHD", ")", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["The", "intracellular", "bacterial", "pathogen", "Chlamydia", "pneumoniae", "C0035243#ent", "<e1>", "has", "been", "associated", "with", "atherosclerosis", "and", "C1956346#ent", "<e2>"], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "the", "C1704693#ent", "<e1>", "component(s)", "for", "the", "observed", "effects", ",", "individual", "C0059438#ent", "<e2>", "were", "tested", "in", "the", "luciferase", "reporter", "system", "at", "concentrations", "found", "within", "the", "active", "fractions"], "h": {"id": "C1704693", "name": "C1704693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059438", "name": "C0059438#ent", "pos": [12, 13]}}
{"token": ["BT", "was", "found", "to", "be", "more", "efficient", "than", "C1704693#ent", "<e1>", "and", "its", "individual", "C0059438#ent", "<e2>", "constituents", "in", "proportionate", "amounts", "in", "abrogating", "production", "of", "NO", "and", "O2(-", ")", "in", "activated", "murine", "peritoneal", "macrophages"], "h": {"id": "C1704693", "name": "C1704693#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059438", "name": "C0059438#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "this", "study", "demonstrates", "that", "a", "recombinant", "human", "C1412362#ent", "<e1>", "can", "stimulate", "a", "lipoxygenase", "other", "than", "mammalian", "C1412361#ent", "<e2>", "(", "S.t", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412361", "name": "C1412361#ent", "pos": [19, 20]}}
{"token": ["The", "present", "investigation", "describes", "the", "ability", "of", "human", "C1412362#ent", "<e1>", "FLAP", ")", "to", "activate", "a", "plant", "C1412361#ent", "<e2>", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412361", "name": "C1412361#ent", "pos": [16, 17]}}
{"token": ["Dimethyl", "sulfoxide", "DMSO", ")", "differentiation", "of", "U937", "cells", "towards", "a", "more", "mature", "monocyte-macrophage", "lineage", "induces", "the", "expression", "of", "C1412362#ent", "<e1>", "but", "not", "C1412361#ent", "<e2>", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412361", "name": "C1412361#ent", "pos": [22, 23]}}
{"token": ["In", "an", "ongoing", "study", "of", "patients", "with", "osteo-", "or", "C0003873#ent", "<e1>", "currently", "in", "its", "fourth", "year", ",", "C0068334#ent", "<e2>", "has", "been", "shown", "to", "be", "relatively", "gastric", "sparing", "compared", "with", "naproxen", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0068334", "name": "C0068334#ent", "pos": [17, 18]}}
{"token": ["Patients", "with", "osteoarthritis", "(", "OA", ")", "or", "C0003873#ent", "<e1>", "RA", ")", "were", "enrolled", "in", "a", "3:1", "ratio", "(", "C0068334#ent", "<e2>", ":", "one", "of", "the", "four", "comparator", "NSAIDs", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0068334", "name": "C0068334#ent", "pos": [18, 19]}}
{"token": ["Experimental", "allergic", "encephalomyelitis", "EAE", ")", ",", "an", "animal", "model", "multiple", "sclerosis", "MS", ")", ",", "is", "useful", "for", "preclinical", "testing", "C0035064#ent", "<e1>", "to", "be", "considered", "for", "treatment", "for", "this", "human", "C0011302#ent", "<e2>"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0011302", "name": "C0011302#ent", "pos": [29, 30]}}
{"token": ["The", "C0035064#ent", "<e1>", "may", "exert", "a", "dual", "beneficial", "effect", "on", "C0011302#ent", "<e2>", "MS", ",", "because", "they", "could", "attenuate", "the", "inflammatory", "process", "improve", "axonal", "conductivity", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011302", "name": "C0011302#ent", "pos": [10, 11]}}
{"token": ["This", "result", "indicates", "that", "both", "the", "new", "probe", "and", "the", "existing", "group", "of", "proximal", "probes", "CKMM", "and", "C1333355#ent", "<e1>", "probably", "flank", "C0011777#ent", "<e2>", "and", "define", "the", "genetic", "interval", "which", "this", "mutation", "maps", "."], "h": {"id": "C1333355", "name": "C1333355#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [21, 22]}}
{"token": ["It", "is", "flanked", "by", "the", "tightly", "linked", "genetic", "markers", "C1333355#ent", "<e1>", "proximally", "and", "D19S51", "distally", ";", "these", "define", "the", "C0011777#ent", "<e2>", "critical", "region"], "h": {"id": "C1333355", "name": "C1333355#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [19, 20]}}
{"token": ["This", "was", "not", "observed", "when", "C0356622#ent", "<e1>", "were", "used", "as", "C2987634#ent", "<e2>", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}}
{"token": ["Other", "agents", "are", "also", "being", "investigated", "for", "their", "postcoital", "contraceptive", "effectiveness", "including", "C0356622#ent", "<e1>", ",", "anti-progestins", ",", "GnRH", "agonists", ",", "C2987634#ent", "<e2>", "antagonists", ",", "and", "HCG", "antagonists", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [20, 21]}}
{"token": ["Cytotoxic", "injury", "characterized", "by", "necrosis", "(", "C0000970#ent", "<e1>", ",", "halothane", ")", "or", "steatosis", "(", "C0037567#ent", "<e2>", ")", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [14, 15]}}
{"token": ["C1421305#ent", "<e1>", "is", "a", "C1413455#ent", "<e2>", "expressed", "in", "many", "tissues", "."], "h": {"id": "C1421305", "name": "C1421305#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413455", "name": "C1413455#ent", "pos": [4, 5]}}
{"token": ["The", "C0949177#ent", "<e1>", "proved", "to", "be", "a", "good", "criteria", "for", "C0011334#ent", "<e2>", "prediction", "in", "this", "population", "."], "h": {"id": "C0949177", "name": "C0949177#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011334", "name": "C0011334#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "the", "human", "gene", "coding", "the", "GM2", "activator", "protein", "the", "AB", "variant", "of", "C0039373#ent", "<e1>", ",", "a", "condition", "that", "is", "clinically", "indistinguishable", "from", "C0039373#ent", "<e1>"], "h": {"id": "C0039373", "name": "C0039373#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0039373", "name": "C0039373#ent", "pos": [14, 15]}}
{"token": ["Insertion", "of", "a", "fourteen", "amino", "acid", "sequence", "RB", "containing", "Thr", "821", "into", "C2984536#ent", "<e1>", "prevents", "binding", "of", "T-Ag", "and", "C1709313#ent", "<e2>", "to", "phosphorylated", "C2984536#ent", "<e1>", "."], "h": {"id": "C2984536", "name": "C2984536#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [19, 20]}}
{"token": ["Standards", "were", "established", "to", "correlate", "C1417130#ent", "<e1>", "and", "contrast", "sensitivity", "as", "well", "as", "C1420708#ent", "<e2>", "and", "the", "defocus", "curve", "measured", "clinically", "."], "h": {"id": "C1417130", "name": "C1417130#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [13, 14]}}
{"token": ["Besides", ",", "the", "effect", "of", "pioglitazone", "and", "C0017642#ent", "<e1>", "on", "the", "plasma", "lipid", "parameters", "(", "C1418830#ent", "<e2>", "and", "PTC", ")", "was", "shown", "in", "these", "diabetic", "rats", "."], "h": {"id": "C0017642", "name": "C0017642#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418830", "name": "C1418830#ent", "pos": [15, 16]}}
{"token": ["Group", "C", "patients", "were", "radiologically", "normal", ",", "currently", "on", "C0012798#ent", "<e1>", "with", "signs", "of", "C0034063#ent", "<e2>"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [14, 15]}}
{"token": ["Nitrates", ",", "C0012798#ent", "<e1>", "morphine", "and", "oxygen", "are", "important", "for", "treating", "C0034063#ent", "<e2>", "and", "should", "be", "administered", "as", "soon", "as", "possible", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [11, 12]}}
{"token": ["C0012798#ent", "<e1>", "nitroglycerin", "and", "sodium", "nitroprusside", "effective", "in", "patients", "with", "concomitant", "C0034063#ent", "<e2>"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [11, 12]}}
{"token": ["C0012798#ent", "<e1>", "administered", "intravenously", "are", "indispensable", "in", "the", "management", "of", "C0034063#ent", "<e2>", "thiazides", "and", "loop", "diuretics", "low", "doses", "effectively", "used", "in", "the", "oral", "treatment", "mild", "to", "moderate", "heart", "failure"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [10, 11]}}
{"token": ["The", "relationship", "of", "C0031111#ent", "<e1>", "to", "disease", "duration", "C0178703#ent", "<e2>", "the", "association", "of", "C0031111#ent", "<e1>", "with", "cardiopulmonary", "disorders", "secondary", "type", "were", "studied", "in", "order", "to", "define", "distinguishing", "features", "between", "the", "two", "."], "h": {"id": "C0178703", "name": "C0178703#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031111", "name": "C0031111#ent", "pos": [3, 4]}}
{"token": ["ret/PTC", "gene", "rearrangements", "rise", "to", "novel", "C0029016#ent", "<e1>", "that", "are", "unique", "to", "C1704885#ent", "<e2>", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704885", "name": "C1704885#ent", "pos": [12, 13]}}
{"token": ["The", "PTC1", "chimeric", "C0029016#ent", "<e1>", "is", "generated", "by", "the", "fusion", "of", "the", "tyrosine", "kinase", "domain", "the", "C1704885#ent", "<e2>", "proto-oncogene", "to", "the", "5'-terminal", "region", "of", "another", "gene", "named", "H4", "(", "D10S170", ")", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704885", "name": "C1704885#ent", "pos": [16, 17]}}
{"token": ["C1414431#ent", "<e1>", "(", "histidine-tryptophane-ketoglutarate", ")", "organ", "preservation", "solution", "has", "been", "shown", "to", "be", "effective", "in", "human", "kidney", "transplantation", "but", "the", "efficacy", "of", "C1414431#ent", "<e1>", "for", "extended", "C0023899#ent", "<e1>", "preservation", "has", "not", "been", "determined", "."], "h": {"id": "C1414431", "name": "C1414431#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [26, 27]}}
{"token": ["These", "results", "suggest", "that", "the", "level", "of", "activity", "of", "C0018969#ent", "<e1>", "reciprocally", "modulate", "intracellular", "heme", "levels", "and", "thus", "activity", "of", "C0002565#ent", "<e2>"], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002565", "name": "C0002565#ent", "pos": [20, 21]}}
{"token": ["Irradiation", "in", "a", "dose", "of", "5", "Gy", "did", "not", "alter", "the", "activity", "of", "C0018969#ent", "<e1>", "caused", "a", "negligible", "reduction", "in", "the", "activity", "of", "C0002565#ent", "<e2>"], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002565", "name": "C0002565#ent", "pos": [23, 24]}}
{"token": ["Although", "C3900049#ent", "<e1>", "is", "a", "valuable", "C0013227#ent", "<e2>", "for", "reduction", "of", "platelet", "levels", "it", "seems", "unable", "to", "stop", "progression", "of", "bone", "marrow", "fibrosis", "hypercellularity", "in", "ET", "and", "PV", "."], "h": {"id": "C3900049", "name": "C3900049#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [6, 7]}}
{"token": ["High", "and", "low", "molecular", "weight", "(", "C1335285#ent", "<e1>", ")", "of", "the", "C1870006#ent", "<e2>", "CD45", ")", "divide", "CD4", "T", "helper", "cells", "subpopulations", "which", "display", "distinct", "characteristics", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [11, 12]}}
{"token": ["Comparisons", "with", "C1335285#ent", "<e1>", "showed", "that", "this", "Ag", "was", "not", "always", "correlated", "with", "C1870006#ent", "<e2>", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [13, 14]}}
{"token": ["ALN", "and", "another", "bisphosphonate", ",", "etidronate", ",", "also", "inhibited", "the", "activities", "of", "other", "bacterially", "expressed", "PTPs", "such", "as", "PTPsigma", "and", "C1335285#ent", "<e1>", "(", "also", "called", "C1870006#ent", "<e2>", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [25, 26]}}
{"token": ["A", "patient", "with", "a", "mediastinal", "germ", "cell", "neoplasm", "fever", ",", "weight", "loss", "pruritus", ",", "and", "C0497156#ent", "<e1>", "ingestion", "of", "C0001975#ent", "<e2>", "."], "h": {"id": "C0497156", "name": "C0497156#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "C0028067#ent", "<e1>", "an", "inhibitor", "of", "C1956140#ent", "<e2>", "were", "compared", "with", "the", "actions", "of", "the", "calcium", "channel", "antagonist", "nifedipine", "on", "noradrenaline-evoked", "contractions", "in", "isolated", "preparations", "of", "the", "rat", "aorta", "."], "h": {"id": "C0028067", "name": "C0028067#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1956140", "name": "C1956140#ent", "pos": [8, 9]}}
{"token": ["C0028067#ent", "<e1>", "a", "selective", "inhibitor", "of", "ClCa", "(", "C1956140#ent", "<e2>", ",", "potentiated", "nitroprusside", "relaxation", "to", "a", "similar", "extent", "as", "chloride", "transport", "inhibitors", "in", "a", "non-additive", "manner", "."], "h": {"id": "C0028067", "name": "C0028067#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1956140", "name": "C1956140#ent", "pos": [8, 9]}}
{"token": ["The", "third", "case", "was", "associated", "with", "condition", ",", "C1858664#ent", "<e1>", ",", "which", "at", "a", "later", "stage", "is", "associated", "with", "C0011847#ent", "<e2>", ",", "the", "result", "of", "pancreatic", "lesion"], "h": {"id": "C1858664", "name": "C1858664#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [19, 20]}}
{"token": ["Both", "B1", "and", "C1333340#ent", "<e1>", "RSF", "are", "constitutive", ",", "but", "C0175697#ent", "<e2>", "treatment", "caused", "induction", "of", "B1", "and", "down-regulation", "of", "C1333340#ent", "<e1>"], "h": {"id": "C1333340", "name": "C1333340#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [10, 11]}}
{"token": ["An", "analogy", "between", "this", "phenomenon", "and", "human", "combined", "immunodeficiency", "disease", "associated", "with", "C0950123#ent", "<e1>", "adenosine", "deaminase", "deficiency", "the", "use", "of", "inhibitors", "of", "C1412179#ent", "<e2>", "the", "management", "of", "T-cell", "acute", "lymphoblastic", "leukemia", "been", "noted", "."], "h": {"id": "C0950123", "name": "C0950123#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [22, 23]}}
{"token": ["The", "combined", "in", "vivo", "in", "vitro", "results", "indicate", "that", "the", "pulsatile", "release", "of", "C1706334#ent", "<e1>", "induced", "by", "norepinephrine", "is", "brought", "about", "by", "C0178469#ent", "<e2>", "of", "NO", "synthase"], "h": {"id": "C1706334", "name": "C1706334#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0178469", "name": "C0178469#ent", "pos": [22, 23]}}
{"token": ["The", "classical", "triad", "Job's", "syndrome", "Hyper-IgE", "syndrome", ",", "a", "C0494261#ent", "<e1>", "includes", "recurrent", "\"", "cold", "\"", "abscesses", ",", "C0032285#ent", "<e2>", "and", "extreme", "elevations", "of", "the", "serum", "IgE", "concentration", "."], "h": {"id": "C0494261", "name": "C0494261#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [18, 19]}}
{"token": ["C0054836#ent", "<e1>", "has", "similar", "efficacy", "to", "other", "beta-blocking", "agents", "C1562036#ent", "<e2>", "ACE", "inhibitors", "hydrochlorothiazide", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1562036", "name": "C1562036#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "overexpression", "of", "cyclin", "D1", "Rat6", "cells", "perturbed", "the", "expression", "of", "several", "cellular", "growth-related", "genes", "c-myc", ",", "C0162508#ent", "<e1>", ",", "and", "cyclin", "A", "but", "not", "C0173532#ent", "<e2>"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0173532", "name": "C0173532#ent", "pos": [27, 28]}}
{"token": ["Effects", "of", "C4082270#ent", "<e1>", "on", "the", "activities", "of", "dehydrogenase", ",", "C0030946#ent", "<e2>", ",", "phosphatase", ",", "urease", "and", "catalase", "in", "activated", "sludge", "were", "investigated", "in", "this", "paper", "."], "h": {"id": "C4082270", "name": "C4082270#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [10, 11]}}
{"token": ["Although", "C1366587#ent", "<e1>", "decreases", "proliferation", "through", "binding", "to", "proliferating", "cell", "nuclear", "antigen", "C0080054#ent", "<e2>", "the", "nucleus", ",", "the", "N", "terminus", "of", "C1366587#ent", "<e1>", "accelerates", "cell", "division"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366587", "name": "C1366587#ent", "pos": [1, 2]}}
{"token": ["Given", "the", "important", "role", "of", "C0080054#ent", "<e1>", "in", "progression", "through", "G2", "and", "M", "phases", "it", "is", "probable", "that", "the", "inhibition", "of", "C0080054#ent", "<e1>", "activity", "accounts", "for", "the", "inhibitory", "effect", "of", "C1366587#ent", "<e1>", "on", "cell", "growth"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366587", "name": "C1366587#ent", "pos": [30, 31]}}
{"token": ["This", "may", "indicate", "that", "in", "situ", "adherent", "curved", "rods", "enclosed", "in", "a", "very", "C0720930#ent", "<e1>", "matrix", "of", "C0032594#ent", "<e2>", "."], "h": {"id": "C0720930", "name": "C0720930#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [17, 18]}}
{"token": ["The", "C0912533#ent", "<e1>", "complex", "with", "C1423827#ent", "<e2>", "participates", "in", "Golgi", "cisternae", "rebuilding", "after", "mitosis", "."], "h": {"id": "C0912533", "name": "C0912533#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1423827", "name": "C1423827#ent", "pos": [5, 6]}}
{"token": ["Initial", "anticonvulsant", "screening", "performed", "using", "intraperitoneal", "(", "C2697645#ent", "<e1>", ")", "maximal", "electroshock-induced", "seizure", "(", "C1417092#ent", "<e2>", ")", ",", "subcutaneous", "pentylenetetrazole", "scPTZ", ")", ",", "and", "subcutaneous", "picrotoxin", "seizure", "threshold", "tests", "."], "h": {"id": "C2697645", "name": "C2697645#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417092", "name": "C1417092#ent", "pos": [14, 15]}}
{"token": ["Death", "was", "due", "to", "C1516009#ent", "<e1>", ",", "bronchopneumonia", "and", "a", "C0024110#ent", "<e2>"], "h": {"id": "C1516009", "name": "C1516009#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024110", "name": "C0024110#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "the", "role", "of", "a", "particular", "PKC", "C0597298#ent", "<e1>", ",", "PKCbeta", ",", "in", "C1522405#ent", "<e2>", "production", "and", "secretion", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [14, 15]}}
{"token": ["The", "characteristics", "of", "the", "C1417500#ent", "<e1>", "+", "effect", "on", "epinephrine-", "and", "C1321914#ent", "<e2>", "desensitizations", "suggest", "a", "similar", "mechanism", "of", "action", "with", "the", "most", "likely", "events", "being", "phosphorylations", "of", "the", "beta-adrenergic", "receptors"], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [11, 12]}}
{"token": ["C1415300#ent", "<e1>", "is", "phosphorylated", "by", "C0054521#ent", "<e2>", "a", "prominent", "constituent", "of", "the", "PSD", "."], "h": {"id": "C1415300", "name": "C1415300#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054521", "name": "C0054521#ent", "pos": [5, 6]}}
{"token": ["Although", "it", "is", "considered", "to", "be", "a", "C3536808#ent", "<e1>", ",", "its", "mucokinetic", "actions", "include", "C0015314#ent", "<e2>", ",", "bronchorrheic", "and", "mucoregulatory", "contributions", "."], "h": {"id": "C3536808", "name": "C3536808#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015314", "name": "C0015314#ent", "pos": [14, 15]}}
{"token": ["In", "hippocampal", "slices", ",", "inhibitors", "of", "C1707154#ent", "<e1>", "reduced", "synaptic", "transmission", "by", "C0022614#ent", "<e2>", "but", "not", "AMPA", "receptors"], "h": {"id": "C1707154", "name": "C1707154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [12, 13]}}
{"token": ["EBP", "is", "a", "ubiquitous", "protein", "that", "is", "normally", "expressed", "in", "the", "cytoplasm", "but", "is", "recruited", "to", "the", "nucleus", "by", "C3274774#ent", "<e1>", "with", "a", "punctate", "localization", "pattern", "characteristic", "of", "the", "C0919528#ent", "<e2>", "chimeric", "proteins"], "h": {"id": "C3274774", "name": "C3274774#ent", "pos": [19, 20]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0919528", "name": "C0919528#ent", "pos": [29, 30]}}
{"token": ["The", "mu-opioid-induced", "activation", "of", "STAT3", "is", "sensitive", "to", "receptor", "was", "further", "shown", "to", "C0043167#ent", "<e1>", "toxin", "treatment", "and", "required", "JAK", "and", "C0282625#ent", "<e2>", "but", "not", "phosphatidylinositol", "3-kinase"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [21, 22]}}
{"token": ["The", "results", "suggested", "that", "the", "up-regulation", "of", "sucrose", "synthase", "glutathione", "S-transferase", "C0669516#ent", "<e1>", "and", "heat", "shock", "protein", "Sti", "(", "C1540116#ent", "<e2>", "may", "contribute", "to", "the", "superior", "root", "thermotolerance", "A.", "scabra", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1540116", "name": "C1540116#ent", "pos": [19, 20]}}
{"token": ["C3891563#ent", "<e1>", "is", "a", "very", "light", "weight", "isoform", "of", "C1335285#ent", "<e2>", "expressed", "on", "activated", "T-cells", "."], "h": {"id": "C3891563", "name": "C3891563#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335285", "name": "C1335285#ent", "pos": [9, 10]}}
{"token": ["Both", "CD4+", "CD8+", "T", "cells", "either", "CD45RA", "or", "C3891563#ent", "<e1>", "isoform", "of", "C1335285#ent", "<e2>", "in", "an", "exclusive", "way", "."], "h": {"id": "C3891563", "name": "C3891563#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335285", "name": "C1335285#ent", "pos": [12, 13]}}
{"token": ["STEs", "are", "formed", "by", "two", "STE", "synthases", "C3812220#ent", "<e1>", "and", "Are2p", ",", "two", "C0014442#ent", "<e2>", "with", "overlapping", "function", ",", "which", "also", "catalyse", "TAG", "formation", ",", "although", "to", "a", "minor", "extent", "."], "h": {"id": "C3812220", "name": "C3812220#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["The", "clinical", "signs", "acute", "and", "included", "depression", "central", "blindness", "head-pressing", ",", "but", "no", "C0030554#ent", "<e1>", ",", "nystagmus", ",", "dorsiflexion", "of", "the", "neck", "or", "C0151818#ent", "<e2>", "were", "observed", "."], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0151818", "name": "C0151818#ent", "pos": [23, 24]}}
{"token": ["Most", "calves", "were", "recumbent", "from", "birth", ",", "and", "many", "developed", "variable", "neurological", "signs", "C0030554#ent", "<e1>", "or", "depression", ",", "limb", "extension", "head", "tremor", "nystagmus", ",", "apparent", "blindness", "and", "C0151818#ent", "<e2>", "when", "stimulated", "."], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0151818", "name": "C0151818#ent", "pos": [27, 28]}}
{"token": ["The", "results", "of", "a", "preliminary", "study", "on", "biological", "responses", "influenza", "virus", "C0682744#ent", "<e1>", "using", "the", "thiosialoside", "polymer", "as", "a", "candidate", "for", "a", "C1443650#ent", "<e2>", "that", "the", "glycopolymer", "has", "potent", "inhibitory", "activity", "the", "C0682744#ent", "<e1>", "."], "h": {"id": "C1443650", "name": "C1443650#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0682744", "name": "C0682744#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "the", "pH", ",", "phosphate", "concentration", "temperature", "and", "polarity", "of", "the", "mobile", "phase", "the", "binding", "of", "C1880218#ent", "<e1>", "and", "L-tryptophan", "to", "C0393754#ent", "<e2>", "were", "examined", "."], "h": {"id": "C1880218", "name": "C1880218#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [23, 24]}}
{"token": ["Frontal", "analysis", "used", "to", "examine", "changes", "in", "the", "association", "constant", "Ka", ")", "and", "moles", "of", "binding", "sites", "mL", ")", "for", "C1880218#ent", "<e1>", "and", "L-tryptophan", "on", "an", "immobilized", "C0393754#ent", "<e2>", "column", "under", "various", "elution", "conditions", "."], "h": {"id": "C1880218", "name": "C1880218#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [27, 28]}}
{"token": ["Our", "data", "suggest", "that", "stabilization", "of", "C2981745#ent", "<e1>", "by", "C0164786#ent", "<e2>", "may", "be", "an", "alternative", "mechanism", "by", "which", "C0164786#ent", "<e2>", "up-regulates", "MDM2", "protein", "and", "exerts", "its", "oncogenic", "effects", "p53", "in", "tumor", "cells"], "h": {"id": "C2981745", "name": "C2981745#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [9, 10]}}
{"token": ["The", "authors", "studied", "31", "cases", "of", "C0010054#ent", "<e1>", "normal", "or", "C0003047#ent", "<e2>", "coronary", "arteries", "black", "Africans", "29.8", "%", "of", "104", "coronary", "patients", "undergoing", "coronary", "angiography", "this", "series", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003047", "name": "C0003047#ent", "pos": [10, 11]}}
{"token": ["Three", "members", "of", "the", "C1332023#ent", "<e1>", "a", "disintegrin", "and", "C0025543#ent", "<e2>", ")", "ADAM-10", ",", "ADAM-17", "(", "TACE", ")", "and", "ADAM-9", "have", "been", "proposed", "as", "alpha-secretases", "."], "h": {"id": "C1332023", "name": "C1332023#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [9, 10]}}
{"token": ["Members", "of", "the", "C1332023#ent", "<e1>", "adisintegrin", "and", "C0025543#ent", "<e2>", ")", "are", "the", "main", "candidates", "for", "physiologically", "relevant", "alpha-secretases", "."], "h": {"id": "C1332023", "name": "C1332023#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [7, 8]}}
{"token": ["CD156", "(", "ADAM8", ")", "is", "part", "of", "the", "C1332023#ent", "<e1>", "proteins", "with", "the", "catalytic", "site", "consensus", "sequence", "C0025543#ent", "<e2>", "and", "disintegrins", "."], "h": {"id": "C1332023", "name": "C1332023#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "the", "nutrient", "excess", "in", "the", "hyperphagic", ",", "hyperinsulinemic", "db/db", "mouse", "primes", "the", "C0669372#ent", "<e1>", "to", "respond", "to", "nutrients", "resulting", "in", "elevated", "C1419748#ent", "<e2>", "activity", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419748", "name": "C1419748#ent", "pos": [25, 26]}}
{"token": ["In", "isolated", "rat", "C0669372#ent", "<e1>", ",", "both", "regulatory", "amino", "acids", "RegAA", ")", "and", "insulin", "coordinately", "activated", "C1419748#ent", "<e2>", "phosphorylation", ",", "which", "was", "completely", "blocked", "by", "rapamycin", ",", "an", "mTOR", "inhibitor", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419748", "name": "C1419748#ent", "pos": [16, 17]}}
{"token": ["The", "conservation", "of", "these", "C1417679#ent", "<e1>", "makes", "them", "of", "great", "agronomical", "importance", "for", "improving", "C1836205#ent", "<e2>", "yields", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1836205", "name": "C1836205#ent", "pos": [14, 15]}}
{"token": ["C0075193#ent", "<e1>", "also", "decreased", "the", "C1839259#ent", "<e2>", "for", "PdBu", "binding", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [5, 6]}}
{"token": ["Inhibitors", "of", "C1413809#ent", "<e1>", "active", "at", "lower", "concentrations", "than", "inhibitors", "of", "C1447694#ent", "<e2>"], "h": {"id": "C1413809", "name": "C1413809#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [11, 12]}}
{"token": ["Soybean", "Bowman-Birk", "protease", "inhibitor", "BBI", ")", "is", "an", "inhibitor", "of", "serine", "proteases", "two", "functional", "inhibitory", "domains", "of", "different", "specificities", ":", "one", "is", "specific", "for", "C1413809#ent", "<e1>", "the", "other", "for", "C1447694#ent", "<e2>"], "h": {"id": "C1413809", "name": "C1413809#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [29, 30]}}
{"token": ["Inhibitors", "of", "C1413809#ent", "<e1>", "more", "effective", "than", "inhibitors", "of", "C1447694#ent", "<e2>"], "h": {"id": "C1413809", "name": "C1413809#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [9, 10]}}
{"token": ["The", "authors", "investigated", "the", "effects", "of", "acute", "late", "sepsis", "on", "neuromuscular", "transmission", "neuromuscular", "actions", "C0069632#ent", "<e1>", "to", "clarify", "the", "mechanisms", "by", "which", "C0243026#ent", "<e2>", "attenuates", "the", "effects", "of", "nondepolarizing", "neuromuscular", "blockers"], "h": {"id": "C0069632", "name": "C0069632#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [22, 23]}}
{"token": ["The", "development", "of", "an", "IgG", "lambda-type", "monoclonal", "gammopathy", "subsequent", "multiple", "myeloma", "an", "C0014544#ent", "<e1>", "patient", "on", "C0031507#ent", "<e2>", "(", "DILANTIN", ")", "therapy", "for", "20", "years", "is", "reported", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [16, 17]}}
{"token": ["A", "comparative", "study", "the", "bioavailability", "of", "seven", "formulations", "of", "C0031507#ent", "<e1>", "was", "carried", "out", "on", "17", "patients", "with", "C0014544#ent", "<e2>", "who", "were", "taking", "C0031507#ent", "<e1>", "regularly", "as", "part", "of", "their", "drug", "therapy"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [9, 10]}}
{"token": ["These", "vectors", "contain", "a", "broad-host-range", "replicon", "and", "C3538747#ent", "<e1>", "RSF1010", ",", "a", "C0008169#ent", "<e2>", "the", "control", "of", "an", "enteric", "consensus", ",", "and", "a", "second", "C3538747#ent", "<e1>", "originally", "derived", "from", "RP4", ")", "."], "h": {"id": "C0008169", "name": "C0008169#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3538747", "name": "C3538747#ent", "pos": [7, 8]}}
{"token": ["Here", "we", "characterize", "the", "Caenorhabditis", "elegans", "C0079429#ent", "<e1>", ",", "encoding", "an", "MKP", "that", "acts", "preferentially", "on", "the", "C0380051#ent", "<e2>", "JNK", ")", "and", "p38", "MAPKs"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [17, 18]}}
{"token": ["The", "incidence", "of", "C0014122#ent", "<e1>", "in", "children", "and", "adults", "with", "congenital", "heart", "disease", "higher", "than", "with", "C0035439#ent", "<e2>", "mitral", "valve", "prolapse"], "h": {"id": "C0014122", "name": "C0014122#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035439", "name": "C0035439#ent", "pos": [16, 17]}}
{"token": ["The", "C0017082#ent", "<e1>", "activity", "was", "strongly", "inhibited", "by", "C0046054#ent", "<e2>", "heparin", "and", "heparan", "sulfate"], "h": {"id": "C0017082", "name": "C0017082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0046054", "name": "C0046054#ent", "pos": [8, 9]}}
{"token": ["Steroid", "therapy", "widely", "used", "in", "patients", "with", "various", "types", "of", "nephritis", "including", "IgA", "nephropathy", "C0017668#ent", "<e1>", "addition", "to", "C0034152#ent", "<e2>"], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [18, 19]}}
{"token": ["To", "identify", "the", "biological", "function", "a", "novel", "molecule", "which", "shows", "high", "homology", "with", "human", "C1415135#ent", "<e1>", "GMPR", ")", "and", "is", "named", "C1415136#ent", "<e2>", "."], "h": {"id": "C1415135", "name": "C1415135#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1415136", "name": "C1415136#ent", "pos": [21, 22]}}
{"token": ["To", "identify", "the", "biological", "function", "a", "novel", "molecule", "which", "shows", "high", "homology", "with", "human", "guanosine", "monophosphate", "reductase", "C1415135#ent", "<e1>", ")", "and", "is", "named", "C1415136#ent", "<e2>", "."], "h": {"id": "C1415135", "name": "C1415135#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415136", "name": "C1415136#ent", "pos": [23, 24]}}
{"token": ["This", "disease", "differs", "from", "other", "dominant", "and", "recessive", "C0752120#ent", "<e1>", "clinically", "because", "of", "the", "prominent", "mental", "deterioration", "C0234133#ent", "<e2>", "and", "pathologically", "because", "of", "cortical", ",", "lentiform", "and", "substantia", "nigra", "neuronal", "loss"], "h": {"id": "C0752120", "name": "C0752120#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [17, 18]}}
{"token": ["In", "the", "present", "study", "we", "demonstrate", "that", "C1424232#ent", "<e1>", "is", "an", "E3", "ubiquitin", "ligase", "acts", "in", "conjunction", "with", "ubiquitin-conjugating", "enzymes", "UbcH5a", "C1421275#ent", "<e2>", ",", "and", "UbcH6", "."], "h": {"id": "C1424232", "name": "C1424232#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421275", "name": "C1421275#ent", "pos": [21, 22]}}
{"token": ["Elevated", "nocturnal", "levels", "of", "Aa-nat", "mRNA", "were", "strongly", "suppressed", "following", "light", "exposure", "C0242889#ent", "<e1>", "administration", ",", "demonstrating", "the", "involvement", "of", "C3887648#ent", "<e2>", "in", "the", "stimulation", "of", "melatonin", "synthesis", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [20, 21]}}
{"token": ["Exposures", "to", "GD-131", ",", "which", "produced", "no", "detectable", "C0242889#ent", "<e1>", "markedly", "slowed", "the", "inactivation", "of", "C3887648#ent", "<e2>", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [15, 16]}}
{"token": ["Treatment", "of", "HKC-8", "cells", "with", "actinomycin", "D", "abolished", "HGF-mediated", "C1335828#ent", "<e1>", "induction", ",", "suggesting", "its", "dependence", "on", "C0812327#ent", "<e2>"], "h": {"id": "C1335828", "name": "C1335828#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [17, 18]}}
{"token": ["Before", "giving", "ACTH", ",", "epileptiform", "EEG", "and", "C0037822#ent", "<e1>", "observed", "in", "all", "the", "five", "children", ",", "C0036572#ent", "<e2>", "in", "four", "of", "them", ",", "behaviour", "disorders", "three", "of", "them", "."], "h": {"id": "C0037822", "name": "C0037822#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [16, 17]}}
{"token": ["In", "several", "disorders", ",", "including", "absorptive", "hypercalciuria", "pseudohypoparathyroidism", ",", "hypophosphatemic", "rickets", "and", "C0263628#ent", "<e1>", "the", "regulation", "of", "the", "C0038302#ent", "<e2>", "to", "be", "altered", "."], "h": {"id": "C0263628", "name": "C0263628#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038302", "name": "C0038302#ent", "pos": [18, 19]}}
{"token": ["The", "bands", "were", "resistant", "to", "digestion", "with", "of", "DNase", "I", "C0018364#ent", "<e1>", "but", "not", "with", "C0035542#ent", "<e2>", "low", "salt", "conditions", ",", "indicating", "that", "they", "consisted", "of", "double", "stranded", "ds", ")", "RNA", "."], "h": {"id": "C0018364", "name": "C0018364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [15, 16]}}
{"token": ["The", "amino", "acid", "residues", "forming", "the", "active", "site", "C0018364#ent", "<e1>", "well", "conserved", "in", "this", "C0035542#ent", "<e2>", "."], "h": {"id": "C0018364", "name": "C0018364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "changes", "in", "C2986643#ent", "<e1>", "concentration", "alter", "plasma", "protein", "of", "AAG-bound", "drugs", "C0023660#ent", "<e2>", "and", "imipramine", "."], "h": {"id": "C2986643", "name": "C2986643#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [13, 14]}}
{"token": ["Preeclampsia", "had", "little", "affect", "on", "serum", "C2986643#ent", "<e1>", "concentrations", "and", "C0023660#ent", "<e2>", "binding", "ratio", "."], "h": {"id": "C2986643", "name": "C2986643#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "for", "a", "better", "assessment", "of", "the", "treatment", "of", "C0085129#ent", "<e1>", "budesonide", ",", "the", "C1254351#ent", "<e2>", "must", "be", "administered", "for", "a", "longer", "period", "of", "time", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}}
{"token": ["The", "authors", "'", "recommendations", "regarding", "C3539565#ent", "<e1>", "use", "in", "various", "C1565106#ent", "<e2>", "summarized", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1565106", "name": "C1565106#ent", "pos": [10, 11]}}
{"token": ["We", "propose", "that", "X-linked", "genes", "silenced", "in", "female", "ES", "cells", "spreading", "of", "Xist", "RNA", "the", "X", "chromosome", "territory", "the", "cells", "differentiate", ",", "with", "silencing", "times", "for", "individual", "C0017337#ent", "<e1>", "dependent", "on", "their", "proximity", "to", "the", "C1421536#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1421536", "name": "C1421536#ent", "pos": [35, 36]}}
{"token": ["Signs", "and", "symptoms", "of", "influenza", "include", "abrupt", "onset", "of", "fever", ",", "severe", "C0231528#ent", "<e1>", ",", "anorexia", ",", "sore", "throat", "headache", ",", "C0010200#ent", "<e2>", ",", "and", "malaise", "."], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [21, 22]}}
{"token": ["Complement", "lysis", "induced", "by", "the", "membrane", "attack", "complex", "C4049728#ent", "<e1>", ")", ",", "an", "aggregate", "of", "C5b", ",", "C6", ",", "C1706327#ent", "<e2>", ",", "C8", "and", "C9", "molecules"], "h": {"id": "C4049728", "name": "C4049728#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706327", "name": "C1706327#ent", "pos": [19, 20]}}
{"token": ["Using", "a", "mixture", "of", "the", "differentially", "labeled", "C5b-6", ",", "the", "C4049728#ent", "<e1>", "was", "assembled", "on", "phospholipid", "vesicles", "addition", "of", "C1706327#ent", "<e2>", ",", "C8", ",", "and", "C9", "."], "h": {"id": "C4049728", "name": "C4049728#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706327", "name": "C1706327#ent", "pos": [19, 20]}}
{"token": ["This", "was", "further", "confirmed", "by", "blocking", "directly", "the", "C3537389#ent", "<e1>", "encoded", "with", "C1416602#ent", "<e2>", "alpha-subunits", "in", "Xenopus", "oocytes"], "h": {"id": "C3537389", "name": "C3537389#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416602", "name": "C1416602#ent", "pos": [12, 13]}}
{"token": ["Kinetic", "variation", "C3537389#ent", "<e1>", "arise", "through", "alternative", "splicing", "of", "C1416602#ent", "<e2>", "mRNA", "and", "combination", "with", "modulatory", "beta", "subunits", "."], "h": {"id": "C3537389", "name": "C3537389#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416602", "name": "C1416602#ent", "pos": [9, 10]}}
{"token": ["All", "polypeptides", "encoded", "by", "RECQL", "C0017337#ent", "<e1>", "share", "a", "central", "region", "seven", "C1310463#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1310463", "name": "C1310463#ent", "pos": [12, 13]}}
{"token": ["The", "N", "gene", "resistance", "to", "Tobacco", "mosaic", "virus", "TMV", ")", "is", "a", "member", "of", "the", "Toll-interleukin", "receptor", "class", "of", "plant", "disease", "(", "R", ")", "C0017337#ent", "<e1>", "that", "recognizes", "the", "C1310463#ent", "<e2>", "the", "TMV", "replicase", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1310463", "name": "C1310463#ent", "pos": [29, 30]}}
{"token": ["It", "also", "suggests", "defective", "regulation", "of", "SLC9A3R1", "or", "NAT9", "by", "C1335654#ent", "<e1>", "as", "a", "susceptibility", "factor", "C0033860#ent", "<e2>", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "report", "the", "identification", "of", "p70", "as", "SHP2", "and", "C1706576#ent", "<e1>", "as", "the", "SH2", "containing", "C0382361#ent", "<e2>", "SHIP", "."], "h": {"id": "C1706576", "name": "C1706576#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0382361", "name": "C0382361#ent", "pos": [16, 17]}}
{"token": ["C1366837#ent", "<e1>", "PCNA", ")", "is", "an", "auxiliary", "protein", "C0012890#ent", "<e2>", "is", "an", "absolute", "requirement", "for", "cellular", "proliferation"], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012890", "name": "C0012890#ent", "pos": [8, 9]}}
{"token": ["Expression", "of", "C1366837#ent", "<e1>", "PCNA", ")", ",", "an", "obligatory", "component", "of", "C0012890#ent", "<e2>", "is", "essential", "for", "proliferation", "and", "has", "been", "shown", "by", "others", "to", "be", "CRE", "dependent", "."], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012890", "name": "C0012890#ent", "pos": [11, 12]}}
{"token": ["Although", "B", "cells", "surface", "C1413696#ent", "<e1>", "and", "are", "the", "main", "peripheral", "blood", "of", "C1419305#ent", "<e2>", "they", "do", "not", "appear", "to", "be", "the", "major", "tissue", "source", "of", "serum", "sCR2"], "h": {"id": "C1413696", "name": "C1413696#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419305", "name": "C1419305#ent", "pos": [13, 14]}}
{"token": ["The", "ability", "of", "famotidine", "to", "control", "gastric", "acid", "hypersecretion", "32", "patients", "with", "C0043515#ent", "<e1>", "compared", "to", "that", "of", "cimetidine", "or", "C0034665#ent", "<e2>", "."], "h": {"id": "C0043515", "name": "C0043515#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [20, 21]}}
{"token": ["In", "predominantly", "cell-mediated", "immunodeficiency", "in", "those", "C0021051#ent", "<e1>", "associated", "to", "defects", "(", "such", "as", ":", "hyper", "IgE", "syndrome", "C0012236#ent", "<e2>", ",", "the", "most", "important", "finding", "was", "a", "significative", "increase", "in", "CD38", "population", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012236", "name": "C0012236#ent", "pos": [18, 19]}}
{"token": ["In", "a", "review", "of", "thymus", "transplants", "in", "a", "variety", "of", "C0021051#ent", "<e1>", "results", "in", "the", "C0012236#ent", "<e2>", "uniformly", "successful", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012236", "name": "C0012236#ent", "pos": [15, 16]}}
{"token": ["C0238062#ent", "<e1>", "CIPO", ")", "is", "a", "C0039082#ent", "<e2>", "defined", "by", "the", "presence", "of", "chronic", "intestinal", "dilation", "and", "dysmotility", "in", "the", "absence", "of", "mechanical", "obstruction", "or", "gross", "inflammatory", "disease"], "h": {"id": "C0238062", "name": "C0238062#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}}
{"token": ["C0238062#ent", "<e1>", "CIP", ")", ",", "a", "C0039082#ent", "<e2>", "of", "disordered", "intestinal", "motility", ",", "is", "characterized", "by", "failure", "of", "the", "intestine", "to", "propel", "its", "contents", "through", "an", "unobstructed", "lumen", "."], "h": {"id": "C0238062", "name": "C0238062#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}}
{"token": ["Recently", ",", "somatostatin", "analogs", "been", "proposed", "as", "therapeutic", "agents", "C0238062#ent", "<e1>", "although", "the", "endogenous", "somatostatin", "pattern", "never", "been", "assessed", "in", "this", "C0039082#ent", "<e2>", "."], "h": {"id": "C0238062", "name": "C0238062#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [21, 22]}}
{"token": ["A", "region", "of", "about", "150", "C3539946#ent", "<e1>", "the", "first", "zinc-finger", "motif", "C1424515#ent", "<e2>", "was", "the", "binding", "site", "p21(Cip1/Waf1", ")", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424515", "name": "C1424515#ent", "pos": [11, 12]}}
{"token": ["Among", "our", "35", "cases", "of", "C0206051#ent", "<e1>", "to", "C0069803#ent", "<e2>", ",", "more", "than", "one", "third", "had", "C0206051#ent", "<e1>", "to", "a", "daily", "moisturizer", "that", "contained", "C0069803#ent", "<e2>", "."], "h": {"id": "C0206051", "name": "C0206051#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0069803", "name": "C0069803#ent", "pos": [8, 9]}}
{"token": ["In", "Europe", "and", "America", ",", "the", "allergen", "immunotherapy", "C1426025#ent", "<e1>", ")", "for", "various", "hay", "C0015967#ent", "<e2>", "or", "allergic", "rhinitis", "enforced", "as", "causal", "treatment", "methods"], "h": {"id": "C1426025", "name": "C1426025#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "by", "using", "the", "microarray", "technique", "we", "have", "identified", "four", "previously", "known", "and", "three", "novel", "C1425190#ent", "<e1>", "potential", "importance", "for", "the", "trabecular", "bone-sparing", "effect", "of", "C2936882#ent", "<e2>", "."], "h": {"id": "C1425190", "name": "C1425190#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [27, 28]}}
{"token": ["Specificity", "of", "this", "heteroassociation", "is", "indicated", "by", "the", "facts", "that", "heteroassociations", "with", "bovine", "serum", "albumin", "were", "not", "observed", "for", "either", "the", "mitochondrial", "dehydrogenase", "the", "C0132555#ent", "<e1>", "or", "between", "C0024544#ent", "<e2>", "citrate", "synthase"], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [28, 29]}}
{"token": ["Uncoupling", "protein", "2", "C1421314#ent", "<e1>", ")", "is", "a", "recently", "described", "C1334043#ent", "<e2>", "of", "the", "uncoupling", "protein", "brown", "adipocytes", "UCP1", ")", ",", "which", "is", "expressed", "at", "high", "levels", "in", "human", "white", "adipose", "tissue"], "h": {"id": "C1421314", "name": "C1421314#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}}
{"token": ["This", "approach", "led", "to", "the", "identification", "of", "C1421314#ent", "<e1>", "and", "UCP3", ",", "two", "C1334043#ent", "<e2>", "of", "the", "brown", "fat", "UCP", "(", "renamed", "UCP1", ")", "."], "h": {"id": "C1421314", "name": "C1421314#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}}
{"token": ["C1421314#ent", "<e1>", "is", "a", "recently", "identified", "C1334043#ent", "<e2>", "found", "in", "many", "tissues", "."], "h": {"id": "C1421314", "name": "C1421314#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}}
{"token": ["Here", "we", "demonstrate", "developmentally", "regulated", "expression", "of", "C1419182#ent", "<e1>", "EC", "1.6.99.7", ")", ",", "an", "C0014442#ent", "<e2>", "required", "for", "recycling", "6,7-[8H]-dihydrobiopterin", "."], "h": {"id": "C1419182", "name": "C1419182#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["The", "modified", "assay", "used", "to", "investigate", "the", "levels", "of", "C1419182#ent", "<e1>", "patients", "with", "malignant", "hyperphenylalaninemia", "results", "of", "assay", "for", "the", "C0014442#ent", "<e2>", "in", "cultured", "cells", "affected", "infants", "and", "parents", "are", "presented", "."], "h": {"id": "C1419182", "name": "C1419182#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}}
{"token": ["Pulpal", "fibroblasts", "nerve", "growth", "factor", "NGF", ")", "and", "the", "low-affinity", "p75", "neurotrophin", "receptor", "their", "sensory", "nerve", "fibers", "C1335268#ent", "<e1>", "and", "C3273659#ent", "<e2>", "and", "pulpal", "sympathetic", "fibers", "C1335268#ent", "<e1>", "."], "h": {"id": "C3273659", "name": "C3273659#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1335268", "name": "C1335268#ent", "pos": [17, 18]}}
{"token": ["These", "biochemical", "and", "biological", "influences", "of", "C1335268#ent", "<e1>", "are", "not", "observed", "using", "a", "mutant", "form", "of", "NGF", "that", "binds", "C3273659#ent", "<e2>", "but", "not", "C1335268#ent", "<e1>", "."], "h": {"id": "C3273659", "name": "C3273659#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1335268", "name": "C1335268#ent", "pos": [6, 7]}}
{"token": ["The", "actual", "prevalence", "and", "the", "clinical", "relevance", "of", "C0678941#ent", "<e1>", "HFE", "(", "which", "are", "linked", "to", "C1384665#ent", "<e2>", ")", "have", "not", "yet", "been", "established", "in", "patients", "on", "chronic", "dialysis"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1384665", "name": "C1384665#ent", "pos": [16, 17]}}
{"token": ["When", "the", "CT", "scans", "100", "patients", "undergoing", "C0002950#ent", "<e1>", "compared", "with", "those", "of", "36", "patients", "with", "C0741160#ent", "<e2>", "no", "threshold", "diameter", "value", "accurately", "discriminated", "between", "the", "two", "groups", "."], "h": {"id": "C0002950", "name": "C0002950#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0741160", "name": "C0741160#ent", "pos": [16, 17]}}
{"token": ["73", "(", "2002", ")", "829", "-", "834", ";", "H.", "Ogura", ",", "T.G.", "Aigner", ",", "C0813872#ent", "<e1>", "Impairs", "recognition", "memory", "rhesus", "monkeys", "comparison", "with", "C0242893#ent", "<e2>", "J.", "Pharmacol", "."], "h": {"id": "C0813872", "name": "C0813872#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [23, 24]}}
{"token": ["The", "anticonflict", "effect", "the", "C2936526#ent", "<e1>", "ondansetron", ",", "was", "investigated", "employing", "an", "operant", "conflict", "C0310298#ent", "<e2>", "in", "pigeons", "."], "h": {"id": "C2936526", "name": "C2936526#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [14, 15]}}
{"token": ["This", "case", "suggests", "that", "viral", "infection", "play", "a", "part", "in", "the", "C0085605#ent", "<e1>", "in", "some", "cases", "of", "C0019202#ent", "<e2>"], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "a", "19-year-old", "woman", "with", "C0085605#ent", "<e1>", "Coomb\u015b", "negative", "hemolytic", "anemia", "and", "renal", "failure", "initial", "manifestations", "of", "C0019202#ent", "<e2>", "recovery", "following", "medical", "treatment"], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [21, 22]}}
{"token": ["Rogers", "et", "al.", "also", "reported", "that", "sodium", "nitroprusside", "inhibited", "the", "stimulation", "of", "C0014442#ent", "<e1>", "secretion", "caused", "by", "CCK-8", "or", "C0256103#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [19, 20]}}
{"token": ["A", "47-year-old", "diabetic", "man", "with", "chronic", "renal", "failure", "with", "a", "1-month", "history", "of", "complete", "C0033377#ent", "<e1>", "of", "the", "left", "upper", "eyelid", "C0015300#ent", "<e2>", "and", "left-sided", "headache"], "h": {"id": "C0033377", "name": "C0033377#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0015300", "name": "C0015300#ent", "pos": [21, 22]}}
{"token": ["Frontal", "mucocele", "presents", "with", "visual", "complaints", "diplopia", ",", "diminution", "of", "vision", ",", "visual", "field", "defect", "C0033377#ent", "<e1>", ",", "orbital", "swelling", "retro-orbital", "pain", "displacement", "of", "eye-globe", "and", "C0015300#ent", "<e2>", "."], "h": {"id": "C0033377", "name": "C0033377#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0015300", "name": "C0015300#ent", "pos": [26, 27]}}
{"token": ["Decarboxylation", "of", "phenylalanine", "by", "aromatic", "L-amino", "acid", "decarboxylase", "C4042618#ent", "<e1>", ")", "is", "the", "rate-limiting", "step", "in", "the", "synthesis", "of", "C0070559#ent", "<e2>", "(", "PE", ")", ",", "a", "putative", "modulator", "of", "dopamine", "transmission", "."], "h": {"id": "C4042618", "name": "C4042618#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0070559", "name": "C0070559#ent", "pos": [19, 20]}}
{"token": ["Effective", "treatments", "for", "C0035854#ent", "<e1>", ",", "including", "topical", "C0025872#ent", "<e2>", "and", "systemic", "antibiotics", "have", "anti-inflammatory", "activity", "which", "may", "be", "more", "important", "than", "their", "antimicrobial", "activity", "this", "setting", "."], "h": {"id": "C0035854", "name": "C0035854#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [8, 9]}}
{"token": ["Rosiglitazone", ",", "a", "selective", "C1428918#ent", "<e1>", "had", "no", "effect", "on", "the", "kinetics", "of", "appearance", "of", "C1413347#ent", "<e2>", "differentiation", "markers", "or", "on", "cell", "size", "granularity", "."], "h": {"id": "C1428918", "name": "C1428918#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413347", "name": "C1413347#ent", "pos": [15, 16]}}
{"token": ["Pregnant", "patients", "who", "have", "undergone", "a", "gastrointestinal", "operation", "C0028754#ent", "<e1>", "who", "have", "active", "inflammatory", "bowel", "disease", "hyperemesis", "gravidarum", "a", "risk", "of", "C1257763#ent", "<e2>", "or", "even", "severe", "malnutrition", "with", "an", "increased", "risk", "of", "spontaneous", "abortion", "fetal", "damage"], "h": {"id": "C0028754", "name": "C0028754#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1257763", "name": "C1257763#ent", "pos": [21, 22]}}
{"token": ["These", "findings", "suggest", "that", "perinatal", "hyperinsulinism", "C0028754#ent", "<e1>", "induced", "by", "maternal", "hyperglycaemia", "and/or", "C1257763#ent", "<e2>", "during", "pregnancy", ",", "are", "risk", "factors", "persistent", "hyperinsulinaemia", "predisposing", "to", "diabetes", "mellitus", "cardiovascular", "disease", "later", "life", "."], "h": {"id": "C0028754", "name": "C0028754#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1257763", "name": "C1257763#ent", "pos": [13, 14]}}
{"token": ["After", "a", "placebo", "wash", "out", "period", ",", "140", "patients", "were", "randomly", "assigned", "to", "receive", "either", "C0287041#ent", "<e1>", "50", "mg", "or", "C0028066#ent", "<e2>", "GITS", "30", "mg", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [20, 21]}}
{"token": ["The", "antihypertensive", "and", "organ-protective", "effects", "of", "the", "combination", "of", "the", "angiotensin", "II", "type", "1", "receptor", "blocker", "C0287041#ent", "<e1>", "and", "the", "calcium", "channel", "blocker", "C0028066#ent", "<e2>", "were", "examined", "in", "Dahl", "salt-sensitive", "rats", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [23, 24]}}
{"token": ["PRINCIPAL", "CONCLUSION", ":", ":", "Although", "diabetes", "is", "a", "chronic", "progressive", "disease", "C0362046#ent", "<e1>", "be", "associated", "to", "subclinical", "alterations", "and", "responsible", "for", "C0268487#ent", "<e2>", "in", "defense", "cells", "in", "repair", "tissue", "failures", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [21, 22]}}
{"token": ["bradykinin", "to", "be", "assessed", "in", "the", "absence", "and", "presence", "of", "captopril", "and", "of", "C0085648#ent", "<e1>", "blockade", "(", "with", "C0025029#ent", "<e2>", ")", "."], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025029", "name": "C0025029#ent", "pos": [18, 19]}}
{"token": ["The", "presented", "case", "suggests", "a", "possible", "pathogenetic", "role", "of", "C4025020#ent", "<e1>", "pregnancy", "in", "the", "development", "of", "C0302809#ent", "<e2>", "recurrent", "infection", "HSV", "in", "healthy", "pregnant", "women"], "h": {"id": "C4025020", "name": "C4025020#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0302809", "name": "C0302809#ent", "pos": [16, 17]}}
{"token": ["In", "Graves", "'", "orbitopathy", "(", "C1822658#ent", "<e1>", ")", ",", "an", "associated", "psychosocial", "burden", "present", "due", "to", "disfiguring", "C0015300#ent", "<e2>", "and/or", "diplopia", ",", "signs", "with", "significant", "impact", "on", "functional", "status", "well-being", "."], "h": {"id": "C1822658", "name": "C1822658#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015300", "name": "C0015300#ent", "pos": [17, 18]}}
{"token": ["The", "above", "findings", "show", "that", "C0055922#ent", "<e1>", "produces", "a", "C0019212#ent", "<e2>", "akin", "to", "autoimmune", "chronic", "active", "hepatitis", "lupoid", "hepatitis", "and", "to", "the", "hepatopathy", "induced", "by", "oxyphenisatin", "."], "h": {"id": "C0055922", "name": "C0055922#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019212", "name": "C0019212#ent", "pos": [9, 10]}}
{"token": ["The", "separation-IFD", "method", "can", "be", "applied", "to", "the", "determination", "of", "C0012544#ent", "<e1>", ",", "such", "as", "F2MDP", ",", "ethane-1-hydroxy-1,1-bisphosphonic", "acid", "dichloromethylene", "bisphosphonic", "acid", "C0771311#ent", "<e2>", "in", "biological", "samples"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [10, 11]}, "relation": "structural_class_of", "t": {"id": "C0771311", "name": "C0771311#ent", "pos": [22, 23]}}
{"token": ["More", "frequently", "associated", "C0012544#ent", "<e1>", "were", "the", "nitrogenated", "bisphosphonates", "pamidronate", ",", "C0771311#ent", "<e2>", "and", "the", "most", "common", "oral", "antecedent", "was", "a", "dental", "extraction"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C0771311", "name": "C0771311#ent", "pos": [11, 12]}}
{"token": ["Possible", "complications", "include", "pseudarthrosis", ",", "thromboembolism", ",", "contracture", "of", "the", "patellar", "tendon", "C0221166#ent", "<e1>", "of", "the", "N.", "peroneus", "C0009492#ent", "<e2>"], "h": {"id": "C0221166", "name": "C0221166#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009492", "name": "C0009492#ent", "pos": [18, 19]}}
{"token": ["In", "the", "patient", "with", "C2931193#ent", "<e1>", "the", "response", "to", "therapy", "with", "C0006684#ent", "<e2>", "be", "assessed", "symptomatically", ",", "electrocardiographically", "(", "that", "is", ",", "by", "ambulatory", "electrocardiographic", "monitoring", ",", "or", "by", "response", "to", "ergonovine", "provocation", "."], "h": {"id": "C2931193", "name": "C2931193#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [11, 12]}}
{"token": ["These", "data", "suggest", "that", "LPS", "may", "stimulate", "CGRP", "release", "and", "[Ca(2+)](i", ")", "elevation", "through", "C1826724#ent", "<e1>", "and", "PKA", ",", "but", "not", "C1418929#ent", "<e2>", "signaling", "pathway", "in", "DRG", "neurons", "of", "neonatal", "rats", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418929", "name": "C1418929#ent", "pos": [21, 22]}}
{"token": ["These", "data", "strongly", "suggest", "that", "the", "inhibitory", "action", "of", "C1826724#ent", "<e1>", "on", "TRPC3", "is", "partly", "mediated", "through", "C1418929#ent", "<e2>", "in", "these", "PKG-overexpressing", "cells", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418929", "name": "C1418929#ent", "pos": [17, 18]}}
{"token": ["The", "C0014930#ent", "<e1>", "tested", "were", "tamoxifen", "(", "C1823559#ent", "<e2>", "5.10(-7", ")", "M", "and", "5.10(-6", ")", "M", ")", "and", "40H", "C1823559#ent", "<e2>", "(", "5.10(-8", ")", "M", "and", "5.10(-7", ")", "M", ")", "."], "h": {"id": "C0014930", "name": "C0014930#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823559", "name": "C1823559#ent", "pos": [7, 8]}}
{"token": ["To", "evaluate", "the", "therapeutic", "effect", "C0013295#ent", "<e1>", "symptoms", "and", "safety", "of", "C0378482#ent", "<e2>", "as", "compared", "with", "omeprazole", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0378482", "name": "C0378482#ent", "pos": [11, 12]}}
{"token": ["We", "report", "here", "that", "MAP", "kinase", "be", "deactivated", "completely", "by", "treatment", "with", "either", "phosphatase", "2A", "a", "C1956003#ent", "<e1>", "for", "phosphoserine", "and", "phosphothreonine", ",", "or", "C1706240#ent", "<e2>", ",", "a", "phosphotyrosine-specific", "protein", "phosphatase"], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706240", "name": "C1706240#ent", "pos": [24, 25]}}
{"token": ["C3250443#ent", "<e1>", "is", "identical", "with", "the", "previously", "known", "minor", "C1710304#ent", "<e2>", "activity", ",", "DIF-3", "."], "h": {"id": "C3250443", "name": "C3250443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [9, 10]}}
{"token": ["Dose-response", "curves", "to", "C0077768#ent", "<e1>", "UK", "14,304", ")", "an", "C2267005#ent", "<e2>", "were", "generated", "in", "the", "absence", "and", "presence", "of", "three", "concentrations", "of", "various", "antagonists", "."], "h": {"id": "C0077768", "name": "C0077768#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2267005", "name": "C2267005#ent", "pos": [9, 10]}}
{"token": ["C0077768#ent", "<e1>", "is", "a", "selective", "C2267005#ent", "<e2>", "to", "treat", "glaucoma", "."], "h": {"id": "C0077768", "name": "C0077768#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2267005", "name": "C2267005#ent", "pos": [5, 6]}}
{"token": ["The", "ability", "of", "C0017628#ent", "<e1>", "and", "of", "gliclazide", "to", "act", "as", "C0022022#ent", "<e2>", "has", "been", "studied", "in", "black", "lipid", "membranes", "of", "glycerol", "monoleate", "a", "function", "of", "pH", "and", "drug", "concentration"], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [11, 12]}}
{"token": ["The", "C1705819#ent", "<e1>", "standard", "mixture", "of", "16", "C1418251#ent", "<e2>", "compounds", "was", "used", "as", "a", "standard", "to", "identify", "and", "quantify", "diesel", "exhaust-derived", "PAHs", "."], "h": {"id": "C1705819", "name": "C1705819#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418251", "name": "C1418251#ent", "pos": [7, 8]}}
{"token": ["These", "results", "indicate", "that", "C0630704#ent", "<e1>", "may", "be", "useful", "as", "a", "therapeutic", "drug", "ischemic", "retinal", "diseases", "such", "as", "C0017601#ent", "<e2>", "and", "retinal", "vascular", "occlusive", "diseases", "that", "involve", "a", "disturbance", "of", "the", "ocular", "circulation"], "h": {"id": "C0630704", "name": "C0630704#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [18, 19]}}
{"token": ["This", "may", "have", "involved", "a", "complex", "mechanism", "of", "one", "or", "more", "factors", "including", "tumor", "cell", "products", "tumor", "specific", "antigens", "immunosuppression", ",", "de-repressed", "oncogene", ",", "or", "an", "activated", "C1336966#ent", "<e1>", "a", "transplacental", "C0009450#ent", "<e2>", "phenomenon", "."], "h": {"id": "C1336966", "name": "C1336966#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [31, 32]}}
{"token": ["Removal", "of", "carbohydrate", "by", "sequential", "treatment", "C1417680#ent", "<e1>", "and", "endoglycosidase", "F", "results", "in", "a", "C1539835#ent", "<e2>", "apparent", "Mr", "=", "220,000", ",", "suggesting", "that", "15", "%", "of", "the", "mass", "of", "the", "native", "alpha", "subunit", "carbohydrate", "."], "h": {"id": "C1417680", "name": "C1417680#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539835", "name": "C1539835#ent", "pos": [14, 15]}}
{"token": ["A", "total", "of", "159", "C0086376#ent", "<e1>", "were", "identified", "from", "the", "reference", "strain", "C1705014#ent", "<e2>", "at", "different", "stages", "of", "phagosome", "maturation", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705014", "name": "C1705014#ent", "pos": [12, 13]}}
{"token": ["Effects", "of", "C2986868#ent", "<e1>", "MAb", "on", "hemolysis", "activities", "of", "C1418887#ent", "<e2>", "were", "measured", "by", "rabbit", "red", "blood", "cells"], "h": {"id": "C2986868", "name": "C2986868#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [9, 10]}}
{"token": ["C1176007#ent", "<e1>", ",", "a", "specific", "inhibitor", "of", "C1705341#ent", "<e2>", "inhibited", "the", "activity", "in", "both", "the", "CQ-S", "and", "CQ-R", "strains", "of", "the", "parasites", "."], "h": {"id": "C1176007", "name": "C1176007#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [7, 8]}}
{"token": ["This", "report", "describes", "the", "effect", "of", "piceatannol", "(", "C1176007#ent", "<e1>", ",", "a", "plant", "secondary", "natural", "product", "on", "protein", "tyrosine", "kinase", "C1705341#ent", "<e2>", ")", "activity", "in", "different", "stages", "of", "P.", "falciparum", "in", "vitro"], "h": {"id": "C1176007", "name": "C1176007#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [20, 21]}}
{"token": ["Intranuclear", "inclusions", "constitute", "a", "pathological", "hallmark", "of", "oculopharyngeal", "muscular", "dystrophy", "OPMD", ")", ",", "a", "dominantly", "inherited", "disease", "by", "(", "GCG", ")", "repeat", "expansions", "in", "the", "C0017337#ent", "<e1>", "that", "encodes", "for", "C1418237#ent", "<e2>", "PABPN1", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1418237", "name": "C1418237#ent", "pos": [30, 31]}}
{"token": ["The", "alteration", "of", "C1332379#ent", "<e1>", "by", "C0133938#ent", "<e2>", "and", "E7", "was", "not", "through", "the", "influence", "on", "the", "Bak", "promoter", "as", "the", "luciferase", "assay", "that", "neither", "C0133938#ent", "<e2>", "nor", "E7", "changed", "the", "C1332379#ent", "<e1>", "promoter", "activity", "."], "h": {"id": "C0133938", "name": "C0133938#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332379", "name": "C1332379#ent", "pos": [3, 4]}}
{"token": ["We", "treated", "her", "C0001623#ent", "<e1>", "prevented", "serious", "hypoglycemia", "by", "giving", "her", "C0032950#ent", "<e2>", "."], "h": {"id": "C0001623", "name": "C0001623#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "the", "safety", "and", "effectiveness", "of", "intravenous", "(IV", "C0015131#ent", "<e1>", "for", "the", "sedation", "of", "patients", "undergoing", "C0030193#ent", "<e2>", "the", "emergency", "department", "ED", ")", "."], "h": {"id": "C0015131", "name": "C0015131#ent", "pos": [9, 10]}, "relation": "may_prevent", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [17, 18]}}
{"token": ["The", "most", "common", "C1456654#ent", "<e1>", "which", "minic", "idiopathic", "Parkinson's", "disease", "collectively", "called", "C0030567#ent", "<e2>"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [12, 13]}}
{"token": ["In", "rabbits", ",", "C0722403#ent", "<e1>", "indirectly", "reduced", "the", "in", "vivo", "serum", "protein", "binding", "C0643808#ent", "<e2>", "through", "the", "interaction", "of", "C0722403#ent", "<e1>", "with", "N4-acetylsulfadimethoxine", "(", "N4-AcSDM", ")", ",", "a", "major", "metabolite", "of", "C0643808#ent", "<e2>", "."], "h": {"id": "C0643808", "name": "C0643808#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0722403", "name": "C0722403#ent", "pos": [3, 4]}}
{"token": ["Increasing", "evidence", "correlates", "alterations", "in", "the", "TK", "system", "urinary", "tract", "diseases", "as", "C0005697#ent", "<e1>", "outflow", "obstruction", "idiopathic", "detrusor", "instability", ",", "and", "C0600040#ent", "<e2>"], "h": {"id": "C0005697", "name": "C0005697#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0600040", "name": "C0600040#ent", "pos": [21, 22]}}
{"token": ["A", "construct", "containing", "2.1", "kb", "C2987231#ent", "<e1>", "5", "'", "flanking", "region", "fused", "to", "a", "C0005220#ent", "<e2>", "(", "lacZ", ")", "gene", ",", "was", "employed", "for", "the", "production", "of", "transgenic", "mice"], "h": {"id": "C2987231", "name": "C2987231#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [14, 15]}}
{"token": ["In", "C3", "plants", "large", "amounts", "of", "photorespiratory", "glycine", "Gly", ")", "are", "converted", "to", "serine", "by", "the", "tetrahydrofolate", "(THF)-dependent", "activities", "of", "the", "C1450945#ent", "<e1>", "GDC", ")", "and", "C1420038#ent", "<e2>", "SHMT", ")", "."], "h": {"id": "C1450945", "name": "C1450945#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420038", "name": "C1420038#ent", "pos": [26, 27]}}
{"token": ["We", "have", "cloned", "and", "characterised", "pkaR", "and", "pkaC", "encoding", "the", "regulatory", "subunit", "PKAR", ")", "and", "the", "catalytic", "subunit", "C1709432#ent", "<e1>", ")", ",", "respectively", ",", "of", "the", "C0010531#ent", "<e2>", "PKA", ")", "of", "M.", "circinelloides", "."], "h": {"id": "C1709432", "name": "C1709432#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [26, 27]}}
{"token": ["We", "have", "cloned", "and", "characterised", "pkaR", "and", "C1709432#ent", "<e1>", "encoding", "the", "regulatory", "subunit", "C0010531#ent", "<e2>", ")", "and", "the", "catalytic", "subunit", "PKAC", ")", ",", "respectively", ",", "of", "the", "cAMP-dependent", "protein", "kinase", "A", "PKA", ")", "of", "M.", "circinelloides", "."], "h": {"id": "C1709432", "name": "C1709432#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [13, 14]}}
{"token": ["We", "have", "cloned", "and", "characterised", "pkaR", "and", "pkaC", "encoding", "the", "regulatory", "subunit", "PKAR", ")", "and", "the", "catalytic", "subunit", "C1709432#ent", "<e1>", ")", ",", "respectively", ",", "of", "the", "cAMP-dependent", "protein", "kinase", "A", "C0010531#ent", "<e2>", ")", "of", "M.", "circinelloides", "."], "h": {"id": "C1709432", "name": "C1709432#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [30, 31]}}
{"token": ["C0068994#ent", "<e1>", "and", "harman", "are", "two", "heterocyclic", "beta-carboline", "(", "9H-pyrido[3,4-b]indole", ")", "C0002062#ent", "<e2>", "with", "biological", "and", "potential", "toxicological", "activity", "that", "appear", "in", "foodstuffs", "and", "environmental", "sources"], "h": {"id": "C0068994", "name": "C0068994#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [11, 12]}}
{"token": ["C0068994#ent", "<e1>", "(", "9H-pyrido-[3,4-b]indol", ")", "represents", "a", "member", "of", "the", "C0002062#ent", "<e2>", "the", "group", "name", "beta-carbolines", "."], "h": {"id": "C0068994", "name": "C0068994#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "show", "that", "in", "addition", "to", "the", "death", "domain", "the", "C-terminal", "tails", "DR4", "and", "C1705132#ent", "<e1>", "positively", "regulate", "C1333530#ent", "<e2>", "binding", ",", "caspase", "activation", "apoptosis", "."], "h": {"id": "C1705132", "name": "C1705132#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333530", "name": "C1333530#ent", "pos": [20, 21]}}
{"token": ["Tumor", "necrosis", "factor-related", "apoptosis", "inducing", "ligand", "(TRAIL)-induced", "apoptosis", "is", "mediated", "by", "its", "receptors", "DR4", "TRAIL-R1", ")", "and", "C1705132#ent", "<e1>", "(", "TRAIL-R2", ")", "and", "the", "adapter", "protein", "Fas-associated", "death", "domain", "protein", "C1333530#ent", "<e2>", ")", "."], "h": {"id": "C1705132", "name": "C1705132#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333530", "name": "C1333530#ent", "pos": [30, 31]}}
{"token": ["Administration", "of", "quinapril", "or", "C0287041#ent", "<e1>", "retarded", "the", "progression", "of", "left", "ventricular", "dysfunction", "attenuated", "cardiac", "sympathetic", "nerve", "abnormalities", "in", "C0018801#ent", "<e2>"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["Under", "sunlight", ",", "hypocotyl", "growth", "C1837550#ent", "<e1>", "showed", "little", "difference", "with", "the", "C1883559#ent", "<e2>", "failed", "to", "respond", "to", "canopy", "shadelight", "."], "h": {"id": "C1837550", "name": "C1837550#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "myosin", "inhibitors", "inhibit", "C1412400#ent", "<e1>", "mRNA", "localization", "in", "chicken", "embryo", "fibroblasts", ",", "suggesting", "a", "C0949646#ent", "<e2>", "mechanism", "for", "Arp2/3-complex", "mRNA", "localization", "."], "h": {"id": "C1412400", "name": "C1412400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0949646", "name": "C0949646#ent", "pos": [17, 18]}}
{"token": ["Bax", "has", "been", "recently", "reported", "to", "be", "an", "C0021699#ent", "<e1>", "associated", "with", "organelles", "or", "bound", "to", "organelles", "by", "C0376515#ent", "<e2>", "or", "a", "soluble", "protein", "in", "the", "cytosol", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [18, 19]}}
{"token": ["These", "results", "are", "consistent", "with", "model", "in", "which", "the", "C0021699#ent", "<e1>", "to", "the", "function", "of", "C0376515#ent", "<e2>", "by", "targeting", "and", "anchoring", "the", "protein", "to", "strategic", "membrane", "locations", "in", "the", "cell", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [15, 16]}}
{"token": ["Inhibition", "of", "NK", "cell", "cytotoxicity", "by", "killer", "cell", "Ig-like", "receptors", "C3540490#ent", "<e1>", ")", "depends", "on", "phosphorylation", "of", "cytoplasmic", "tyrosines", "C3540490#ent", "<e1>", ",", "which", "recruit", "C1430988#ent", "<e1>", "Src", "homology", "protein", "tyrosine", "phosphatase", "1"], "h": {"id": "C3540490", "name": "C3540490#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [24, 25]}}
{"token": ["Of", "the", "thalassemic", "conditions", ",", "12", "involved", "beta-thalassemia", ",", "3", "C0472762#ent", "<e1>", ",", "1", "delta", "beta-thalassemia", ",", "and", "1", "C0271990#ent", "<e2>", "."], "h": {"id": "C0472762", "name": "C0472762#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0271990", "name": "C0271990#ent", "pos": [19, 20]}}
{"token": ["We", "present", "the", "hematologic", "data", "of", "825", "cases", "of", "C0472762#ent", "<e1>", "687", "cases", "of", "C0472762#ent", "<e1>", "138", "cases", "of", "C0271990#ent", "<e1>", "."], "h": {"id": "C0472762", "name": "C0472762#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0271990", "name": "C0271990#ent", "pos": [19, 20]}}
{"token": ["The", "resulting", "leakage", "response", "was", "not", "inhibited", "by", "L658,758", ",", "an", "inhibitor", "of", "C0699918#ent", "<e1>", "enzymatic", "activity", ",", "but", "by", "C0079225#ent", "<e2>"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0079225", "name": "C0079225#ent", "pos": [20, 21]}}
{"token": ["It", "can", "present", "with", "shiny", "papules", "sharply", "marginated", "infiltrated", "erythematous", "scaling", "plaques", ",", "with", "follicular", "C0024003#ent", "<e1>", "on", "the", "C0240940#ent", "<e2>", ",", "neck", ",", "trunk", "and", "limbs", "."], "h": {"id": "C0024003", "name": "C0024003#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0240940", "name": "C0240940#ent", "pos": [19, 20]}}
{"token": ["C3469521#ent", "<e1>", "FA", ")", "is", "an", "C1275089#ent", "<e2>", "by", "progressive", "pancytopenia", "and", "a", "high", "risk", "malignancies", ",", "particularly", "acute", "myelogenous", "leukemia", "AML", ")", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1275089", "name": "C1275089#ent", "pos": [6, 7]}}
{"token": ["C3469521#ent", "<e1>", "FA", ")", "is", "a", "genetically", "heterogeneous", "C1275089#ent", "<e2>", "associated", "with", "chromosomal", "instability", "hypersensitivity", "to", "DNA", "cross-linking", "agents", "and", "predisposition", "to", "malignancy", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1275089", "name": "C1275089#ent", "pos": [8, 9]}}
{"token": ["C3469521#ent", "<e1>", "FA", ")", "is", "an", "C1275089#ent", "<e2>", "by", "progressive", "pancytopenia", "and", "a", "high", "risk", "malignanci", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1275089", "name": "C1275089#ent", "pos": [6, 7]}}
{"token": ["Fanconi's", "anaemia", "C3469521#ent", "<e1>", ")", "is", "a", "rare", "C1275089#ent", "<e2>", "by", "progressive", "lethal", "pancytopenia", "skeletal", "abnormalities", "hyperpigmentation", "and", "increased", "chromosomal", "aberrations"], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1275089", "name": "C1275089#ent", "pos": [8, 9]}}
{"token": ["Presumably", "C0009002#ent", "<e1>", "produces", "an", "increase", "in", "the", "rate", "of", "hydrolysis", "of", "C0008385#ent", "<e2>", "the", "rat", "liver", "."], "h": {"id": "C0009002", "name": "C0009002#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [12, 13]}}
{"token": ["The", "Minnesota", "Department", "of", "Health", "C0024544#ent", "<e1>", ")", "was", "notified", "of", "an", "outbreak", "of", "C0009763#ent", "<e2>", "in", "city", "A", "with", "cultures", "positive", "for", "Streptococcus", "pneumoniae"], "h": {"id": "C0024544", "name": "C0024544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [14, 15]}}
{"token": ["The", "identification", "of", "this", "C2984552#ent", "<e1>", "a", "novel", "C0919528#ent", "<e2>", "fusion", "implies", "that", "an", "indirect", "RAS-deregulating", "mechanism", "could", "be", "involved", "in", "leukemic", "transformation", "."], "h": {"id": "C2984552", "name": "C2984552#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919528", "name": "C0919528#ent", "pos": [8, 9]}}
{"token": ["We", "examined", "C0497580#ent", "<e1>", "Japanese", "males", "for", "the", "presence", "of", "human", "papillomavirus", "HPV", ")", "C0017428#ent", "<e2>", "by", "Southern", "blot", "hybridization"], "h": {"id": "C0497580", "name": "C0497580#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [14, 15]}}
{"token": ["All", "except", "one", "patient", "were", "receiving", "a", "C0012798#ent", "<e1>", "and", "all", "but", "one", "a", "beta-blocking", "agent", "the", "time", "of", "C0026196#ent", "<e2>", "treatment", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026196", "name": "C0026196#ent", "pos": [19, 20]}}
{"token": ["BP", "control", "remained", "satisfactory", "in", "nine", "patients", "for", "at", "least", "one", "year", "after", "substitution", "and", "in", "all", ",", "C0012798#ent", "<e1>", "required", "with", "C0026196#ent", "<e2>", "to", "control", "fluid", ",", "were", "discontinued", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0026196", "name": "C0026196#ent", "pos": [22, 23]}}
{"token": ["Moreover", ",", "perturbation", "of", "the", "association", "of", "TFIIB", "with", "Sp1", "by", "C1417833#ent", "<e1>", "was", "reflected", "in", "the", "reduced", "recruitment", "of", "C0035679#ent", "<e2>", "the", "promoter", "."], "h": {"id": "C1417833", "name": "C1417833#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [20, 21]}}
{"token": ["The", "hypochromic", ",", "C0085576#ent", "<e1>", "the", "most", "frequently", "encountered", "C0002871#ent", "<e2>", "on", "a", "world-wide", "scale", ",", "with", "iron", "deficiency", "anemia", "ranking", "as", "the", "commonest", "."], "h": {"id": "C0085576", "name": "C0085576#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [9, 10]}}
{"token": ["While", "folic", "acid", "deficiency", "C0085576#ent", "<e1>", "non-renal", "patients", ",", "the", "relevance", "of", "altered", "folate", "metabolism", "C0002871#ent", "<e2>", "of", "end-stage", "renal", "disease", "its", "response", "to", "rHu-EPO", "is", "less", "clear", "."], "h": {"id": "C0085576", "name": "C0085576#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [15, 16]}}
{"token": ["Pericardial", "fluid", "accumulates", "the", "C0007209#ent", "<e1>", "purine", "metabolites", ",", "as", "well", "as", "the", "endogenous", "C0042397#ent", "<e2>", "ET-1", ")", "."], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [14, 15]}}
{"token": ["A", "high", "dose", "corticosteroids", "should", "have", "a", "beneficial", "effect", ",", "and", ",", "for", "C0027947#ent", "<e1>", "patients", "with", "C0744471#ent", "<e2>", "fever", ",", "transfusion", "with", "functional", "neutrophils", "improves", "survival", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0744471", "name": "C0744471#ent", "pos": [17, 18]}}
{"token": ["Continuous", "infusion", "CI", ")", "of", "ceftazidime", "has", "been", "demonstrated", "to", "add", "clinical", "advantages", "the", "treatment", "of", "infection", "of", "C0027947#ent", "<e1>", "patients", ",", "especially", "in", "the", "presence", "of", "C0744471#ent", "<e2>"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0744471", "name": "C0744471#ent", "pos": [27, 28]}}
{"token": ["We", "investigated", "whether", "C0114346#ent", "<e1>", "influences", "the", "pharmacokinetics", "of", "platinum", "drugs", "co-administered", "with", "cisplatin", "or", "C0079083#ent", "<e2>", "."], "h": {"id": "C0114346", "name": "C0114346#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [15, 16]}}
{"token": ["Hence", ",", "C0114346#ent", "<e1>", "does", "not", "significantly", "influence", "the", "pharmacokinetics", "of", "cisplatin", "and", "C0079083#ent", "<e2>", "in", "pediatric", "cancer", "patients", "."], "h": {"id": "C0114346", "name": "C0114346#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [13, 14]}}
{"token": ["C0114346#ent", "<e1>", ",", "a", "reactive", "thiol", "often", "encounters", "cisplatin", "and", "C0079083#ent", "<e2>", "in", "combination", "protocols", "oxazaphosphorines", "and", "platinum", "drugs"], "h": {"id": "C0114346", "name": "C0114346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [10, 11]}}
{"token": ["Pneumocystis", "carinii", "a", "pathogen", "that", "causes", "a", "potentially", "lethal", "C0032285#ent", "<e1>", "in", "patients", "with", "AIDS", "and", "other", "C0221026#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0221026", "name": "C0221026#ent", "pos": [17, 18]}}
{"token": ["Widespread", "efforts", "are", "now", "under", "way", "to", "elucidate", "the", "pathogenesis", "of", "these", "C0032285#ent", "<e1>", "to", "identify", "the", "C0221026#ent", "<e2>", "predisposing", "patients", "to", "serious", "disease"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0221026", "name": "C0221026#ent", "pos": [17, 18]}}
{"token": ["Pneumocystis", ",", "a", "fungal", ",", "extracellular", "pathogen", "a", "life-threatening", "C0032285#ent", "<e1>", "in", "patients", "with", "severe", "C0221026#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0221026", "name": "C0221026#ent", "pos": [15, 16]}}
{"token": ["Isolates", "of", "Pneumocystis", "carinii", "f.", "sp.", "hominis", "examined", "from", "six", "individuals", "who", "died", "of", "P.", "carinii", "C0032285#ent", "<e1>", "between", "1968", "and", "1981", "and", "who", "had", "underlying", "C0221026#ent", "<e2>", "which", "were", "not", "due", "to", "human", "immunodeficiency", "virus", "infection"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C0221026", "name": "C0221026#ent", "pos": [26, 27]}}
{"token": ["Detailed", "studies", "of", "C0314614#ent", "<e1>", "needed", "to", "test", "for", "deleterious", "substitutions", "in", "C0017337#ent", "<e2>", "and", "to", "date", "the", "origins", "of", "plant", "sex", "chromosomes"], "h": {"id": "C0314614", "name": "C0314614#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["Antihypertensive", "drug", "therapy", "be", "most", "efficient", "and", "effective", "if", "directed", "at", "those", "who", ",", "by", "virtue", "of", "their", "constellation", "of", "risk", "factors", "evidence", "of", "C0042373#ent", "<e1>", "are", "likely", "to", "have", "a", "C0027051#ent", "<e2>", "stroke", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [24, 25]}, "relation": "related_to", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [31, 32]}}
{"token": ["C1413221#ent", "<e1>", "is", "a", "C1415740#ent", "<e2>", "ectoenzyme", "that", "catalyzes", "both", "the", "synthesis", "of", "cyclic", "ADP-ribose", "NAD+", "and", "its", "hydrolysis", "to", "ADP-ribose", "."], "h": {"id": "C1413221", "name": "C1413221#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [4, 5]}}
{"token": ["C1413221#ent", "<e1>", "is", "a", "C1415740#ent", "<e2>", "ectoenzyme", "that", "behaves", "either", "as", "an", "enzyme", ",", "a", "cell", "adhesion", "molecule", "as", "a", "cell", "surface", "receptor", "in", "cell", "signalling"], "h": {"id": "C1413221", "name": "C1413221#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [4, 5]}}
{"token": ["Axonemes", "of", "C0162572#ent", "<e1>", "(", "Tetrahymena", "thermophila", ")", "cilia", ",", "isolated", "by", "the", "C0012050#ent", "<e2>", "were", "treated", "briefly", "with", "trypsin", "after", "removal", "of", "the", "ciliary", "membranes", "treatment", "with", "Triton", "X-100"], "h": {"id": "C0162572", "name": "C0162572#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012050", "name": "C0012050#ent", "pos": [13, 14]}}
{"token": ["Intracellular", "Ca(2+)", "the", "activation", "of", "mitogen-activated", "protein", "kinase", "MAPK", ")", "in", "HMC-1", ",", "especially", "C1539079#ent", "<e1>", "and", "p44", "isoforms", "extracellular", "signal-regulated", "kinase", "ERK", ")", "and", "C1120843#ent", "<e2>", "but", "not", "c-Jun", "N-terminal", "kinase", "JNK", ")", "."], "h": {"id": "C1539079", "name": "C1539079#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [25, 26]}}
{"token": ["Haloperidol", "prevented", "the", "antagonism", "of", "C2677317#ent", "<e1>", "by", "C0003596#ent", "<e2>", "but", "pimozide", "was", "ineffective", "in", "blocking", "C0003596#ent", "<e2>", "."], "h": {"id": "C2677317", "name": "C2677317#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [8, 9]}}
{"token": ["Young", ",", "healthy", "outpatients", "(", "100", ")", "undergoing", "restorative", "dentistry", "oral", "surgery", "C0014277#ent", "<e1>", "oxide-oxygen", "anaesthesia", "were", "given", "0.014", "mg/kg", "of", "C0013136#ent", "<e2>", "or", "a", "saline", "placebo", "i.v", "."], "h": {"id": "C0014277", "name": "C0014277#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013136", "name": "C0013136#ent", "pos": [21, 22]}}
{"token": ["The", "incidence", "of", "cardiac", "dysrhythmia", "inpatient", "dental", "anaesthesia", "with", "C0014277#ent", "<e1>", "was", "studied", "following", "either", "hyoscine", "or", "C0013136#ent", "<e2>", "as", "a", "supplement", "to", "papaveretum", "premedication", "."], "h": {"id": "C0014277", "name": "C0014277#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013136", "name": "C0013136#ent", "pos": [17, 18]}}
{"token": ["C1825346#ent", "<e1>", "downregulation", "heralds", "the", "hypodynamic", "response", "in", "severe", "C0036690#ent", "<e2>", "."], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [9, 10]}}
{"token": ["In", "this", "review", "we", "will", "focus", "on", "the", "hereditary", "breast", "carcinomas", "by", "mutations", "in", "BRCA1", ",", "BRCA2", ",", "C0015625#ent", "<e1>", "FANC", ")", "genes", ",", "C1259236#ent", "<e2>", "and", "ATM", "tumour", "genes", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1259236", "name": "C1259236#ent", "pos": [24, 25]}}
{"token": ["We", "investigated", "the", "incidence", ",", "clinical", "and", "immunological", "characteristics", "of", "human", "immuno-deficiency", "virus", "HIV", ")", "infection", "in", "a", "group", "of", "multi-transfused", "patients", "with", "C0005283#ent", "<e1>", "major", "who", "were", "exposed", "to", "C0019693#ent", "<e2>"], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [30, 31]}}
{"token": ["The", "case", "of", "17-year-old", "boy", "with", "C0005283#ent", "<e1>", "major", "who", "contracted", "the", "human", "immunodeficiency", "virus", "C0019693#ent", "<e2>", ")", "through", "multiple", "transfusions", "described", "."], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [15, 16]}}
{"token": ["C0010592#ent", "<e1>", "interacts", "with", "MPA", "by", "inhibiting", "the", "multidrug", "resistance-associated", "protein", "2", "C2828741#ent", "<e2>", ")", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2828741", "name": "C2828741#ent", "pos": [12, 13]}}
{"token": ["On", "the", "basis", "of", "EPR", "and", "electronic", "absorption", "for", "Co(II)-substituted", "AAP", ",", "none", "of", "the", "C0001975#ent", "<e1>", "studied", "binds", "to", "the", "dinuclear", "metallo-active", "site", "of", "C0051989#ent", "<e2>", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0051989", "name": "C0051989#ent", "pos": [25, 26]}}
{"token": ["All", "of", "the", "C0001975#ent", "<e1>", "studied", "were", "competitive", "inhibitors", "of", "C0051989#ent", "<e2>", "with", "K(i", ")", "values", "between", "860", "and", "0.98", "mM."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0051989", "name": "C0051989#ent", "pos": [10, 11]}}
{"token": ["Normal", "pituitary", "gonadal", "function", "be", "maintained", "with", "long", "term", "pulsatile", "GnRH", "administration", "in", "men", "with", "C0342384#ent", "<e1>", "IHH", ")", ",", "and", "both", "C0032002#ent", "<e2>", "and", "gonadal", "priming", "occur", "during", "the", "process", "of", "GnRH-induced", "sexual", "maturation"], "h": {"id": "C0342384", "name": "C0342384#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [22, 23]}}
{"token": ["The", "phenomena", "associated", "with", "C0035078#ent", "<e1>", "contrasted", "with", "those", "seen", "in", "patients", "with", "C0001403#ent", "<e2>"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [13, 14]}}
{"token": ["IFN-gamma", "R0/0", "mice", "died", "of", "the", "disease", "up", "to", "day", "10", "postinfection", ",", "whereas", "immunocompetent", "C2987364#ent", "<e1>", "(", "WT", ")", "mice", "developed", "a", "C0085315#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085315", "name": "C0085315#ent", "pos": [23, 24]}}
{"token": ["The", "acylation", "of", "rat", "brain", "proteolipid", "protein", "C1335272#ent", "<e1>", ")", "with", "tritiated", "palmitic", ",", "C0028928#ent", "<e2>", ",", "and", "myristic", "acids", "studied", "in", "vivo", "in", "vitro", "compared", "with", "the", "acylation", "of", "lipids", "."], "h": {"id": "C1335272", "name": "C1335272#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [14, 15]}}
{"token": ["The", "results", "suggest", "a", "preferential", "acylation", "of", "C1335272#ent", "<e1>", "with", "palmitic", "and", "C0028928#ent", "<e2>", "compared", "with", "myristic", "acid"], "h": {"id": "C1335272", "name": "C1335272#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "decreased", "C0059037#ent", "<e1>", "does", "not", "predict", "the", "histologic", "features", "of", "C0085694#ent", "<e2>", "gallstones", "."], "h": {"id": "C0059037", "name": "C0059037#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085694", "name": "C0085694#ent", "pos": [12, 13]}}
{"token": ["C0032143#ent", "<e1>", "treatment", "enhanced", "the", "expression", "of", "C0265220#ent", "<e2>", "mRNA", ",", "as", "measured", "by", "Northern", "analysis"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0265220", "name": "C0265220#ent", "pos": [7, 8]}}
{"token": ["Data", "on", "the", "incidence", "of", "C0205721#ent", "<e1>", "and", "after", "the", "introduction", "of", "propofol", "with", "C0013618#ent", "<e2>", "indicates", "that", "there", "have", "been", "no", "further", "cluster", "outbreaks", "individual", "C0205721#ent", "<e1>", "to", "have", "been", "reduced", "."], "h": {"id": "C0205721", "name": "C0205721#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [14, 15]}}
{"token": ["DEPs", "exposure", "increased", "8", "of", "10", "responses", "including", "C1419120#ent", "<e1>", "and", "levels", "of", "IL-4", ",", "C1334103#ent", "<e2>", ",", "TNFalpha", ",", "total", "protein", "cysteinyl", "leukotrienes", "and", "eosinophils", "in", "bronchoalveolar", "lavage", "fluid", "BALF", ")", "."], "h": {"id": "C1419120", "name": "C1419120#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334103", "name": "C1334103#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "we", "studied", "the", "inhibition", "of", "C0070122#ent", "<e1>", "binding", "to", "C3814032#ent", "<e2>", "by", "quipazine", "and", "N-methyl-quipazine", "(", "NMQ", ")", "."], "h": {"id": "C0070122", "name": "C0070122#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3814032", "name": "C3814032#ent", "pos": [12, 13]}}
{"token": ["Interactions", "with", "other", "C3814032#ent", "<e1>", "antagonists", ",", "including", "C0070122#ent", "<e2>", "and", "cocaine", ",", "as", "well", "as", "the", "C3814032#ent", "<e1>", "substrates", "5-hydroxytryptamine", "and", "d-amphetamine", "were", "unaffected", "by", "interconversion", "of", "this", "residue", "."], "h": {"id": "C0070122", "name": "C0070122#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3814032", "name": "C3814032#ent", "pos": [3, 4]}}
{"token": ["A", "protein", "factor", "purified", "from", "ribosomes", "of", "Escherichia", "coli", "RC(rel", "cells", "starved", "for", "an", "amino", "acid", "stimulates", "C0035681#ent", "<e1>", "synthesis", "by", "core", "and", "C0035678#ent", "<e2>"], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [17, 18]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [23, 24]}}
{"token": ["The", "RNA", "species", "specifically", "replicated", "by", "C0035681#ent", "<e1>", "they", "were", "not", "accepted", "as", "templates", "by", "the", "C0035678#ent", "<e2>", "Escherichia", "coli", "bacteriophage", "SP6", "by", "Qbeta", "replicase", "T3", "RNA", "polymerase", "partially", "active", "."], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [16, 17]}}
{"token": ["C1851466#ent", "<e1>", "which", "is", "produced", "from", "the", "rearranged", "gene", "between", "AML1", "and", "C1539715#ent", "<e2>", "in", "myeloid", "leukemia", "t(8;21)", "chromosomal", "translocation", "plays", "an", "important", "role", "in", "the", "pathogenesis", "of", "leukemia", "."], "h": {"id": "C1851466", "name": "C1851466#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1539715", "name": "C1539715#ent", "pos": [12, 13]}}
{"token": ["In", "4", "patients", "with", "AML-M2b", "of", "normal", "karyotype", ",", "C1851466#ent", "<e1>", "mRNA", "and/or", "rearrangements", "of", "AML1", "and", "C1539715#ent", "<e2>", "detected", "."], "h": {"id": "C1851466", "name": "C1851466#ent", "pos": [9, 10]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1539715", "name": "C1539715#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "have", "characterized", "rat", "bone", "marrow-derived", "DC", "(", "BMDC", ")", "and", "compared", "them", "with", "DC", "isolated", "from", "spleen", "(", "C1419891#ent", "<e1>", ")", "and", "pseudo-afferent", "lymph", "(", "C1416936#ent", "<e2>", ")", "."], "h": {"id": "C1419891", "name": "C1419891#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1416936", "name": "C1416936#ent", "pos": [27, 28]}}
{"token": ["The", "5.75", "%", "C0026818#ent", "<e1>", "phantom", "and", "all", "tissues", "showed", "C1419385#ent", "<e2>", "dispersion", "with", "B1L", ",", "whereas", "the", "1.0", "mM", "MnCI2", "phantom", "showed", "no", "significant", "B1L", "dependence", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [10, 11]}}
{"token": ["The", "clinical", "picture", "can", "be", "differentiated", "from", "C0403399#ent", "<e1>", "CNS", ")", "or", "C0027726#ent", "<e2>", "INS", ")", "with", "respect", "to", "the", "age", "of", "onset", ",", "outcome", ",", "and", "morphological", "appearance", "."], "h": {"id": "C0403399", "name": "C0403399#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [12, 13]}}
{"token": ["Insertion", "of", "the", "C3889703#ent", "<e1>", "facilitated", "by", "the", "use", "of", "a", "C1366498#ent", "<e2>", "cat", ")", "gene", "."], "h": {"id": "C3889703", "name": "C3889703#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366498", "name": "C1366498#ent", "pos": [11, 12]}}
{"token": ["Prior", "induction", "of", "C3813609#ent", "<e1>", "also", "attenuated", "NO-mediated", "decreases", "in", "cellular", "C1705556#ent", "<e2>", "levels", ",", "but", "did", "not", "decrease", "nitrotyrosine", "formation", "."], "h": {"id": "C3813609", "name": "C3813609#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [11, 12]}}
{"token": ["A", "63-year-old", "woman", "received", "Quinupristin/Dalfopristin", "for", "C0520575#ent", "<e1>", "fever", ",", "arthralgia", ",", "vomiting", ",", "and", "C0239377#ent", "<e2>", "erythematous", "skin", "plaques", "."], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [15, 16]}}
{"token": ["Most", "mature", "T", "cells", "the", "C0524890#ent", "<e1>", "either", "CD4", "or", "C1706438#ent", "<e2>", ";", "however", ",", "there", "is", "a", "small", "population", "alpha", "beta+", "TCR", "T", "cells", "that", "lack", "both", "CD4", "and", "C1706438#ent", "<e2>", "."], "h": {"id": "C0524890", "name": "C0524890#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [10, 11]}}
{"token": ["Endogenous", "C0524890#ent", "<e1>", "first", "detected", "when", "double-positive", "thymocytes", "down-regulate", "either", "CD4", "or", "C1706438#ent", "<e2>", "."], "h": {"id": "C0524890", "name": "C0524890#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [12, 13]}}
{"token": ["The", "expression", "of", "C0079423#ent", "<e1>", "induced", "with", "C0039512#ent", "<e2>", "in", "Escherichia", "coli", "the", "mature", "protease", "region", "cloned", "into", "pET15b", "and", "SDS-PAGE", "showed", "expressed", "product", "clearly", ",", "but", "no", "alkaline", "protease", "activity", "was", "detected", "."], "h": {"id": "C0079423", "name": "C0079423#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [7, 8]}}
{"token": ["Despite", "these", "effects", ",", "C0059239#ent", "<e1>", "does", "not", "play", "an", "essential", "role", "in", "targeting", "C3853558#ent", "<e2>", "to", "major", "cellular", "substrates", "CAS", "and", "paxillin", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3853558", "name": "C3853558#ent", "pos": [14, 15]}}
{"token": ["In", "viral", "Src", "(v-Src)-transformed", "cells", ",", "C0059239#ent", "<e1>", "FAK", ")", "associates", "with", "C3853558#ent", "<e2>", "by", "combined", "v-Src", "SH2", "gain-of-function", "v-Src", "SH3", "domain", "to", "FAK", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3853558", "name": "C3853558#ent", "pos": [12, 13]}}
{"token": ["In", "viral", "Src", "(v-Src)-transformed", "cells", ",", "focal", "adhesion", "kinase", "C0059239#ent", "<e1>", ")", "associates", "with", "C3853558#ent", "<e2>", "by", "combined", "v-Src", "SH2", "gain-of-function", "v-Src", "SH3", "domain", "to", "C0059239#ent", "<e1>", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3853558", "name": "C3853558#ent", "pos": [14, 15]}}
{"token": ["The", "severity", "of", "the", "C0010346#ent", "<e1>", "itself", "may", "overshadow", "C1565489#ent", "<e2>"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [9, 10]}}
{"token": ["Another", "agent", "with", "C1412114#ent", "<e1>", "blocking", "properties", ",", "C0237417#ent", "<e2>", ",", "has", "been", "used", "clinically", "to", "reverse", "cardiac", "conduction", "abnormalities", "induced", "by", "amitriptyline", "."], "h": {"id": "C1412114", "name": "C1412114#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0237417", "name": "C0237417#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "it", "blocks", "the", "highly", "tumorigenic", ",", "constitutively", "activated", "variant", "of", "C0242984#ent", "<e1>", ",", "EGFRvIII", ",", "and", "inhibits", "C1332447#ent", "<e2>", "both", "the", "Ras/MAP", "kinase", ",", "and", "PI-3", "kinase/AKT", "pathways", "."], "h": {"id": "C0242984", "name": "C0242984#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [20, 21]}}
{"token": ["There", "is", "currently", "a", "lack", "of", "evidence", "linking", "ART", "with", "the", "remaining", "six", "imprinting", "syndromes", ":", "Prader-Willi", "syndrome", "Russell-Silver", "syndrome", "maternal", "and", "paternal", "uniparental", "disomy", "chromosome", "14", "C3494506#ent", "<e1>", "transient", "neonatal", "C0011849#ent", "<e2>", "."], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [31, 32]}}
{"token": ["No", "correlation", "between", "relative", "amyloid", "resistance", "C1420017#ent", "<e1>", "genotype", "was", "observed", ",", "indicating", "that", "C1420017#ent", "<e1>", "RFLPs", "have", "no", "value", "predicting", "predisposition", "to", "C0002726#ent", "<e1>", "the", "mouse", "model", "."], "h": {"id": "C1420017", "name": "C1420017#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [23, 24]}}
{"token": ["This", "first", "demonstration", "of", "the", "participation", "of", "C1420017#ent", "<e1>", "in", "pathogenesis", "of", "C0002726#ent", "<e2>", "in", "vivo", "that", "inhibition", "of", "C1420017#ent", "<e1>", "binding", "to", "amyloid", "fibrils", "an", "attractive", "therapeutic", "target", "in", "a", "range", "of", "serious", "human", "diseases"], "h": {"id": "C1420017", "name": "C1420017#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [12, 13]}}
{"token": ["C3811118#ent", "<e1>", "produced", "no", "brain", "injury", "did", "increase", "C1527149#ent", "<e2>", "after", "C3811118#ent", "<e1>", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [8, 9]}}
{"token": ["Exogenous", "bioactive", "CGRP", "mimicked", "the", "beneficial", "effect", "of", "C3811118#ent", "<e1>", "and", "up-regulated", "the", "expression", "of", "C1527149#ent", "<e2>", "HSP70", ")", ",", "which", "might", "act", "as", "the", "end", "effector", "to", "maintain", "cell", "viability"], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "pure", "narcotic", "antagonists", "naloxone", "and", "C2343921#ent", "<e1>", ",", "and", "their", "quaternary", "derivatives", ",", "C0030073#ent", "<e2>", "and", "methylnaltrexone", ",", "were", "examined", "in", "reversing", "the", "catalepsy", "induced", "by", "morphine", "in", "rats", "."], "h": {"id": "C2343921", "name": "C2343921#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030073", "name": "C0030073#ent", "pos": [16, 17]}}
{"token": ["The", "diastereomeric", "6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone", "derivatives", "of", "C2343921#ent", "<e1>", "(", "4a", "and", "5a", ")", "and", "of", "C0030073#ent", "<e2>", "(", "4b", "and", "5b", ")", "were", "prepared", "from", "their", "parent", "ketones"], "h": {"id": "C2343921", "name": "C2343921#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030073", "name": "C0030073#ent", "pos": [14, 15]}}
{"token": ["As", "with", "its", "TBI", "activity", ",", "the", "potency", "of", "C1418823#ent", "<e1>", "to", "inhibit", "the", "C1382029#ent", "<e2>", "was", "intermediate", "between", "that", "of", "asialo-hCGp", "and", "hCGc", "."], "h": {"id": "C1418823", "name": "C1418823#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [14, 15]}}
{"token": ["Among", "the", "three", "batches", "of", "C1418823#ent", "<e1>", ",", "their", "inhibitory", "effects", "on", "bTSH", "binding", "and", "C1382029#ent", "<e2>", "activation", "appeared", "to", "vary", "inversely", "with", "with", "their", "sialic", "acid", "content", "."], "h": {"id": "C1418823", "name": "C1418823#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [15, 16]}}
{"token": ["Proliferation", "of", "all", "the", "cell", "lines", "C1335812#ent", "<e1>", "was", "inhibited", "by", "C0053355#ent", "<e2>", "."], "h": {"id": "C1335812", "name": "C1335812#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0053355", "name": "C0053355#ent", "pos": [11, 12]}}
{"token": ["The", "patients", "had", "features", "commonly", "found", "in", "C0033788#ent", "<e1>", "including", "claw", "hands", "joint", "stiffness", "aortic", "valve", "involvement", "and", "C0086795#ent", "<e2>"], "h": {"id": "C0033788", "name": "C0033788#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0086795", "name": "C0086795#ent", "pos": [18, 19]}}
{"token": ["Mucolipidosis", "III", "C0033788#ent", "<e1>", "is", "a", "rare", "autosomal", "recessively", "inherited", "C0086795#ent", "<e2>"], "h": {"id": "C0033788", "name": "C0033788#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0086795", "name": "C0086795#ent", "pos": [10, 11]}}
{"token": ["The", "phenotype", "of", "C0033788#ent", "<e1>", "ML", "II", ",", "a", "disorder", "of", "lysosomal", "enzyme", "transport", "includes", "mucopolysaccharidosis", "type", "I", "C0086795#ent", "<e2>", "syndrome)-like", "features", "and", "dysostosis", "multiplex", "usually", "apparent", "after", "6", "months", "of", "age", "."], "h": {"id": "C0033788", "name": "C0033788#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0086795", "name": "C0086795#ent", "pos": [18, 19]}}
{"token": ["PKC", "alpha", "C3273872#ent", "<e1>", ",", "delta", ",", "epsilon", "and", "C3889400#ent", "<e2>", "were", "all", "detected", "in", "hearts", "from", "both", "control", "and", "diabetic", "rats", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889400", "name": "C3889400#ent", "pos": [9, 10]}}
{"token": ["These", "FS/D1h", "cells", "express", "C3273837#ent", "<e1>", "immunoreactivity", "and", "produce", "IL-6", "but", "not", "pituitary", "hormones", "as", "C3539616#ent", "<e2>", ",", "ACTH", ",", "FSH", ",", "and", "LH", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [15, 16]}}
{"token": ["Finally", ",", "in", "vitro", "assay", "suggests", "that", "C1567710#ent", "<e1>", "may", "serve", "as", "the", "direct", "phosphorylation", "target", "for", "C1705632#ent", "<e2>", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705632", "name": "C1705632#ent", "pos": [17, 18]}}
{"token": ["More", "importantly", ",", "H(2)O(2)-mediated", "C1567710#ent", "<e1>", "activation", "is", "subject", "to", "regulation", "by", "C1705632#ent", "<e2>", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705632", "name": "C1705632#ent", "pos": [12, 13]}}
{"token": ["To", "compare", "clinical", "and", "microbiological", "efficacy", "penicillines", "and", "C0282563#ent", "<e1>", "in", "patients", "with", "exacerbation", "of", "C0008677#ent", "<e2>", "CB", ")", "basing", "on", "long-term", "follow-up", "after", "antibacterial", "treatment"], "h": {"id": "C0282563", "name": "C0282563#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [15, 16]}}
{"token": ["Given", "the", "overlap", "in", "pathogenesis", "between", "DPB", "and", "other", "chronic", "respiratory", "diseases", "C0282563#ent", "<e1>", "are", "being", "investigated", "for", "cystic", "fibrosis", "asthma", ",", "C0008677#ent", "<e2>", "chronic", "sinusitis", "and", "chronic", "obstructive", "pulmonary", "disease"], "h": {"id": "C0282563", "name": "C0282563#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [22, 23]}}
{"token": ["Cystic", "fibrosis", "CF", ")", "C0034049#ent", "<e1>", "by", "impaired", "chloride", "secretion", "to", "eventual", "C0264490#ent", "<e2>"], "h": {"id": "C0034049", "name": "C0034049#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [12, 13]}}
{"token": ["In", "C0162429#ent", "<e1>", "patients", "with", "a", "raised", "C1413766#ent", "<e2>", ",", "there", "was", "no", "relationship", "between", "malnutrition", "determined", "by", "body", "mass", "index", "anthropometry", "and", "either", "albumin", "of", "IGF-1", "concentrations", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413766", "name": "C1413766#ent", "pos": [7, 8]}}
{"token": ["Test", "and", "retest", "scores", "on", "the", "Symptom", "Rating", "Test", "SRT", ")", ",", "Manifest", "Anxiety", "Scale", "C0025048#ent", "<e1>", ")", "and", "Maudsley", "Personality", "Inventory", "(", "C1417244#ent", "<e2>", ")", "were", "obtained", "from", "45", "non-psychotic", "psychiatric", "in-patients", "."], "h": {"id": "C0025048", "name": "C0025048#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417244", "name": "C1417244#ent", "pos": [23, 24]}}
{"token": ["In", "a", "murine", "C0025297#ent", "<e1>", "model", "induced", "by", "C0519030#ent", "<e2>", "Streptococcus", "pneumoniae", "ceftriaxone", "was", "more", "active", "than", "ampicillin", "or", "cefotaxime", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0519030", "name": "C0519030#ent", "pos": [8, 9]}}
{"token": ["This", "is", "a", "case", "report", "a", "cerebellar", "abscess", "C0025297#ent", "<e1>", "caused", "by", "Shewanella", "putrefaciens", "C0519030#ent", "<e2>", "a", "river", "trap", "fisherman", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0519030", "name": "C0519030#ent", "pos": [14, 15]}}
{"token": ["The", "use", "of", "bifunctional", "aluminum", "to", "degrade", "methyl", "tert-butyl", "ether", "C0066286#ent", "<e1>", ")", "in", "the", "presence", "of", "C0599874#ent", "<e2>", "has", "been", "examined", "using", "batch", "systems"], "h": {"id": "C0066286", "name": "C0066286#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0599874", "name": "C0599874#ent", "pos": [17, 18]}}
{"token": ["Extra-articular", "symptoms", "consisting", "almost", "exclusively", "of", "ocular", "involvement", ",", "occurred", "in", "three", "patients", "only", "(", "two", "cases", "of", "C0009774#ent", "<e1>", "and", "one", "of", "C0701807#ent", "<e2>", "."], "h": {"id": "C0009774", "name": "C0009774#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0701807", "name": "C0701807#ent", "pos": [23, 24]}}
{"token": ["Subsequent", "microinjection", "of", "the", "selective", "5-HT(1A)", "receptor", "WAY-100635", "into", "RPa", "reversed", "the", "C1412726#ent", "<e1>", "thermolytic", "effects", "of", "C0050079#ent", "<e2>", ",", "returning", "C1412726#ent", "<e1>", "SNA", "and", "C1412726#ent", "<e1>", "temperature", "to", "the", "elevated", "levels", "after", "leptin", "."], "h": {"id": "C1412726", "name": "C1412726#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0050079", "name": "C0050079#ent", "pos": [17, 18]}}
{"token": ["A", "C1417002#ent", "<e1>", "haplotype", "was", "associated", "with", "alcoholism", "independently", "from", "C3273505#ent", "<e2>", "."], "h": {"id": "C1417002", "name": "C1417002#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273505", "name": "C3273505#ent", "pos": [10, 11]}}
{"token": ["Polycomb", "group", "PcG", ")", "and", "trithorax", "group", "trxG", ")", "proteins", "act", "as", "antagonistic", "regulators", "to", "maintain", "transcriptional", "OFF", "C1420342#ent", "<e1>", "states", "of", "C0017347#ent", "<e2>", "and", "other", "target", "genes", "."], "h": {"id": "C1420342", "name": "C1420342#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017347", "name": "C0017347#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "the", "C0250870#ent", "<e1>", "effect", "on", "C0812281#ent", "<e2>", "generation", "was", "completely", "abolished", "by", "a", "GST", "inhibitor", ",", "indicating", "an", "essential", "role", "of", "GST", "in", "maspin-mediated", "cellular", "response", "to", "oxidative", "stress"], "h": {"id": "C0250870", "name": "C0250870#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [7, 8]}}
{"token": ["Cardiac", "catheterization", "angiocardiography", "and", "ventricular", "muscle", "biopsy", "performed", "in", "forty", "patients", "with", "C1449563#ent", "<e1>", "included", "21", "cases", "of", "hypertrophic", "cardiomyopathy", "19", "cases", "of", "C1449563#ent", "<e1>"], "h": {"id": "C1449563", "name": "C1449563#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1449563", "name": "C1449563#ent", "pos": [12, 13]}}
{"token": ["Recent", "evidence", "suggests", "that", "the", "most", "common", "form", "of", "C1449563#ent", "<e1>", "our", "altitudes", ",", "the", "dilated", "cardiomyopathy", "C1449563#ent", "<e1>", ")", ",", "is", "a", "post-infectious", "autoimmune", "disease", "is", "triggered", "by", "virus", "infections"], "h": {"id": "C1449563", "name": "C1449563#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1449563", "name": "C1449563#ent", "pos": [9, 10]}}
{"token": ["MN", "was", "characterized", "by", "weakness", ",", "C0026821#ent", "<e1>", "wasting", ",", "reduced", "tendon", "reflexes", "muscle", "pain", "C0004134#ent", "<e2>", ",", "restless", "legs", "hypesthesia", ",", "paresthesia", ",", "dysesthesia", ",", "and", "vegetative", "impairment", "."], "h": {"id": "C0026821", "name": "C0026821#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [15, 16]}}
{"token": ["A", "simple", "mathematical", "algorithm", "been", "applied", "to", "two", "polymorphic", "enzymes", "C0755322#ent", "<e1>", "and", "G6PD", ")", "correlated", "with", "past", "C0024530#ent", "<e2>", "morbidity", "in", "Sardinia", "and", "the", "Po", "River", "delta", "."], "h": {"id": "C0755322", "name": "C0755322#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [18, 19]}}
{"token": ["The", "model", "system", "was", "RNA", "polymerase", "II", "C0035679#ent", "<e1>", ",", "whose", "density", "on", "particular", "C0011519#ent", "<e2>", "under", "various", "conditions", "is", "well", "documented", "."], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [14, 15]}}
{"token": ["The", "model", "system", "was", "C0035679#ent", "<e1>", "Pol", "II", ",", "whose", "density", "on", "particular", "C0011519#ent", "<e2>", "under", "various", "conditions", "is", "well", "documented", "."], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [13, 14]}}
{"token": ["This", "C0020924#ent", "<e1>", "an", "inhibitor", "of", "C3850052#ent", "<e2>", "including", "those", "involved", "in", "steroidogenesis", "."], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3850052", "name": "C3850052#ent", "pos": [6, 7]}}
{"token": ["Since", "the", "phosphate", "contents", "in", "glycogen", "synthase", "sites", "3", "and", "2", "are", "altered", "in", "C0011847#ent", "<e1>", "and", "by", "insulin", "administration", "the", "possible", "involvement", "of", "the", "C0536221#ent", "<e2>", "explored", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [25, 26]}}
{"token": ["C0286185#ent", "<e1>", "is", "a", "T-type", "calcium-channel", "antagonist", "C0042402#ent", "<e2>", "negative", "chronotropic", "effects"], "h": {"id": "C0286185", "name": "C0286185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [7, 8]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "assess", "the", "mechanism", "of", "action", "of", "C0286185#ent", "<e1>", ",", "a", "new", "T-channel", "calcium", "blocker", "is", "a", "C0042402#ent", "<e2>", "with", "negative", "chronotropic", "properties", "."], "h": {"id": "C0286185", "name": "C0286185#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [23, 24]}}
{"token": ["The", "C1334090#ent", "<e1>", "mediates", "sorting", "of", "lysosomal", "C3541394#ent", "<e2>", "and", "recycles", "between", "the", "trans-Golgi", "network", "and", "endosomes", "."], "h": {"id": "C1334090", "name": "C1334090#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}}
{"token": ["Intravenous", "procainamide", "C0025887#ent", "<e1>", "could", "suppress", "the", "reinduction", "of", "sustained", "C0042510#ent", "<e2>", "in", "4", "(", "67", "%", ")", "of", "6", "patients", "."], "h": {"id": "C0025887", "name": "C0025887#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [10, 11]}}
{"token": ["Four", "patients", "(", "including", "3", "patients", "who", "experienced", "recurrence", ")", "received", "amiodarone", "alone", "or", "in", "combination", "with", "C0025887#ent", "<e1>", ",", "and", "these", "drugs", "could", "effectively", "prevent", "recurrence", "of", "C0042510#ent", "<e2>", "."], "h": {"id": "C0025887", "name": "C0025887#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [28, 29]}}
{"token": ["C0025887#ent", "<e1>", "and", "lidocaine", "elevated", "both", "RE", "and", "C0042510#ent", "<e2>", "thresholds", "."], "h": {"id": "C0025887", "name": "C0025887#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [8, 9]}}
{"token": ["Heparin", ",", "which", "binds", "to", "these", "domains", "of", "both", "proteins", ",", "strongly", "inhibits", "binding", "of", "C1420884#ent", "<e1>", "to", "Link_TSG6", "and", "TSG-6Q", ",", "but", "C0178695#ent", "<e2>", "does", "not", "."], "h": {"id": "C1420884", "name": "C1420884#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0178695", "name": "C0178695#ent", "pos": [23, 24]}}
{"token": ["The", "absence", "of", "detectable", "C0050690#ent", "<e1>", "in", "the", "strain", "in", "which", "all", "POX4", "and", "POX5", "C0017337#ent", "<e2>", "had", "been", "disrupted", "confirmed", "that", "all", "functional", "acyl-CoA", "oxidase", "genes", "been", "inactivated", "."], "h": {"id": "C0050690", "name": "C0050690#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["C0050690#ent", "<e1>", "AOX", ")", ",", "a", "bona", "fide", "PPARalpha", "target", "C0017337#ent", "<e2>", ",", "was", "induced", "by", "ciprofibrate", "but", "slower", "and", "more", "strongly", "than", "FPP", "synthase"], "h": {"id": "C0050690", "name": "C0050690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["Timely", "treatment", "with", "activated", "C0001275#ent", "<e1>", "hemoperfusion", "with", "pulse", "steroid", "C1161438#ent", "<e2>", "was", "attempted", "in", "both", "cases", ";", "however", ",", "both", "cases", "died", "within", "five", "days", "owing", "to", "multiple", "organ", "failure"], "h": {"id": "C0001275", "name": "C0001275#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [10, 11]}}
{"token": ["She", "was", "managed", "with", "C0001275#ent", "<e1>", "hemoperfusion", "x", "2", ",", "megadose", "of", "C1161438#ent", "<e2>", ",", "and", "methylprednisolone", "pulse", "therapy"], "h": {"id": "C0001275", "name": "C0001275#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [12, 13]}}
{"token": ["Cross-reacting", "antigens", "mainly", "of", "C0175697#ent", "<e1>", "core-lipid", "A", "present", "in", "the", "C0014122#ent", "<e2>", "and", "CPS", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [11, 12]}}
{"token": ["The", "decrease", "in", "C1705281#ent", "<e1>", "in", "mouse", "testis", "also", "selective", ",", "as", "the", "expression", "of", "C1413702#ent", "<e2>", ",", "GATA-1", ",", "and", "SGP1", "were", "little", "affected", "by", "irradiation", "."], "h": {"id": "C1705281", "name": "C1705281#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413702", "name": "C1413702#ent", "pos": [15, 16]}}
{"token": ["In", "comparative", "clinical", "trials", "ampicillin/sulbactam", "has", "proved", "to", "be", "a", "significant", "drug", "in", "the", "therapeutic", "armamentarium", "for", "lower", "respiratory", "tract", "infections", "aspiration", "pneumonia", "gynaecological/obstetrical", "infections", "intra-abdominal", "infections", "paediatric", "infections", "as", "acute", "epiglottitis", "periorbital", "cellulitis", "C0744130#ent", "<e1>", "and", "skin", "and", "C0149778#ent", "<e2>"], "h": {"id": "C0744130", "name": "C0744130#ent", "pos": [34, 35]}, "relation": "NA", "t": {"id": "C0149778", "name": "C0149778#ent", "pos": [39, 40]}}
{"token": ["C0028066#ent", "<e1>", "and", "nicardipine", "competed", "with", "C0073746#ent", "<e2>", "for", "the", "DHP", "receptor", "as", "evidenced", "by", "the", "change", "in", "percentage", "of", "group", "I", "proteins"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0073746", "name": "C0073746#ent", "pos": [6, 7]}}
{"token": ["The", "findings", "indicate", "that", "C3887685#ent", "<e1>", "is", "primarily", "responsible", "for", "the", "metabolism", "of", "C0086214#ent", "<e2>", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086214", "name": "C0086214#ent", "pos": [13, 14]}}
{"token": ["Remission", "of", "C0339143#ent", "<e1>", "obtained", "in", "22", "patients", "(", "11", "by", "C1412613#ent", "<e2>", ",", "1", "by", "iodine", "and", "10", "by", "Ri", ")", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412613", "name": "C1412613#ent", "pos": [11, 12]}}
{"token": ["Thirty-four", "patients", "with", "C0339143#ent", "<e1>", "first", "rendered", "euthyroid", "with", "antithyroid", "drugs", "C1412613#ent", "<e2>", ")", "then", "given", "supplementary", "thyroxine", "(", "T4", ")", ",", "were", "randomly", "allocated", "to", "three", "treatment", "groups"], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412613", "name": "C1412613#ent", "pos": [11, 12]}}
{"token": ["The", "human", "SWI/SNF", "(", "hSWI/SNF", ")", "C0059946#ent", "<e1>", "chromatin", "remodeling", "complex", "is", "a", "tumor", "suppressor", "essential", "C1336778#ent", "<e2>"], "h": {"id": "C0059946", "name": "C0059946#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336778", "name": "C1336778#ent", "pos": [16, 17]}}
{"token": ["Our", "aim", "was", "to", "investigate", "the", "association", "of", "C0033847#ent", "<e1>", "with", "genetic", "variation", "genes", "coding", "for", "C0633225#ent", "<e2>"], "h": {"id": "C0033847", "name": "C0033847#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0633225", "name": "C0633225#ent", "pos": [16, 17]}}
{"token": ["These", "peptides", "activated", "the", "same", "receptor", "binding", "sites", "C3273436#ent", "<e1>", "and", "SRTX-b", "at", "the", "picomolar", "sites", "ET-3", "and", "C0259475#ent", "<e2>", "at", "the", "nanomolar", "sites", "to", "produce", "cyclic", "GMP", "but", "their", "signaling", "pathways", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0259475", "name": "C0259475#ent", "pos": [18, 19]}}
{"token": ["Likewise", ",", "the", "cyclo-oxygenase", "inhibitor", "indomethacin", ",", "markedly", "potentiated", "the", "contractile", "responses", "C3273436#ent", "<e1>", ",", "but", "not", "to", "C0259475#ent", "<e2>", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0259475", "name": "C0259475#ent", "pos": [18, 19]}}
{"token": ["Induction", "of", "phosphoinositide", "hydrolysis", "rat", "cerebellar", "slices", "endothelins", "(", "C3273436#ent", "<e1>", "and", "ET-3", ")", "and", "sarafotoxins", "(", "SRTX-b", "and", "C0259475#ent", "<e2>", ")", "was", "demonstrated", "by", "measurement", "of", "labelled", "inositol", "phosphate", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0259475", "name": "C0259475#ent", "pos": [19, 20]}}
{"token": ["For", "C0020476#ent", "<e1>", "single", "drug", "choices", "include", "nicotinic", "acid", "lovastatin", ",", "and", "C0017245#ent", "<e2>", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0017245", "name": "C0017245#ent", "pos": [12, 13]}}
{"token": ["The", "results", "suggest", "that", "both", "C0132515#ent", "<e1>", "and", "indomethacin", "inhibit", "myometrial", "contractility", "mechanisms", "independent", "of", "C0389003#ent", "<e2>", "inhibition", "."], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0389003", "name": "C0389003#ent", "pos": [15, 16]}}
{"token": ["C0132515#ent", "<e1>", "is", "a", "non-steroidal", "anti-inflammatory", "drug", "NSAID", ")", "which", "preferentially", "inhibits", "C0389003#ent", "<e2>", "has", "been", "associated", "with", "total", "of", "13", "reported", "cases", "of", "severe", "liver", "injury", "our", "case", "."], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0389003", "name": "C0389003#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "influence", "of", "Ibuprofen", ",", "C0132515#ent", "<e1>", "and", "Rofecoxib", ",", "C0389003#ent", "<e2>", "COX-1", ")", "and", "cyclooxygenase", "2", "COX-2", ")", "inhibitors", "and", "Budesonide", "on", "the", "nasal", "polyps", "fibroblasts", "proliferation"], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0389003", "name": "C0389003#ent", "pos": [16, 17]}}
{"token": ["A", "positive", "regulation", "of", "C0525678#ent", "<e1>", "is", "carried", "out", "by", "CDC25", "product", "which", "facilitates", "the", "C1366909#ent", "<e2>", "RAS", "proteins"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366909", "name": "C1366909#ent", "pos": [15, 16]}}
{"token": ["C0017536#ent", "<e1>", "is", "an", "C0030499#ent", "<e2>", "dogs", "and", "able", "to", "infect", "human", "beings", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [4, 5]}}
{"token": ["C0017536#ent", "<e1>", "and", "cryptosporidiosis", "are", "C0030499#ent", "<e2>", "humans", ",", "domestic", "animals", "and", "wildlife", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [5, 6]}}
{"token": ["When", "an", "epsilon(m)-globin", "C0079429#ent", "<e1>", "was", "placed", "between", "the", "delta-", "and", "C2827561#ent", "<e2>", "it", "remained", "silent", "during", "embryonic", "erythropoiesis", "only", "the", "LCR-proximal", "wild-type", "epsilon-globin", "gene", "expressed", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2827561", "name": "C2827561#ent", "pos": [11, 12]}}
{"token": ["A", "hygromycin", "B", "resistance", "hygro(R", ")", ")", "C0079429#ent", "<e1>", "was", "inserted", "into", "the", "human", "C2827561#ent", "<e2>", "chromosome", "11", "a", "mouse/human", "hybrid", "erythroid", "cell", "line", "that", "expresses", "the", "human", "beta-globin", "gene", "the", "induction", "of", "differentiation", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2827561", "name": "C2827561#ent", "pos": [14, 15]}}
{"token": ["We", "have", "evaluated", "the", "relationship", "between", "systolic", "blood", "pressure", "C1705296#ent", "<e1>", ")", "and", "age", ",", "body", "mass", "index", "BMI", ")", ",", "waist", "circumference", "C3714642#ent", "<e2>", "to", "potassium", "ratio", "Na/K", ")", ",", "and", "tobacco", "use", "in", "an", "urban", "African", "population"], "h": {"id": "C1705296", "name": "C1705296#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [23, 24]}}
{"token": ["In", "the", "18000", "x", "g", "supernatant", "only", "one", "substrate", ",", "5", "beta-cholestan-3", "alpha-ol", "was", "found", "to", "be", "25-", "and", "26-hydroxylated", "and", "no", "C0283470#ent", "<e1>", "of", "any", "C0038317#ent", "<e2>", "could", "be", "detected", "."], "h": {"id": "C0283470", "name": "C0283470#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [26, 27]}}
{"token": ["Activated", "leukocytes", "and", "C0064833#ent", "<e1>", "elicit", "a", "hypercoagulable", "state", "C0243025#ent", "<e2>", "in", "patients", "with", "malignant", "lymphoma", "chemotherapy", "."], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243025", "name": "C0243025#ent", "pos": [9, 10]}}
{"token": ["To", "elucidate", "the", "interrelationship", "between", "active", "oxygen", "C0064833#ent", "<e1>", "PMN", "elastase", "in", "patients", "with", "septic", "adult", "respiratory", "distress", "syndrome", "C0243025#ent", "<e2>", ")", ",", "we", "examined", "the", "relationship", "between", "alpha-tocopherol", ",", "which", "has", "an", "antioxidant", "action", "and", "PMN", "elastase"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243025", "name": "C0243025#ent", "pos": [19, 20]}}
{"token": ["The", "partition", "coefficients", "C0054616#ent", "<e1>", "and", "water", "indicated", "that", "KB-2796", "was", "less", "hydrophobic", "than", "C0016295#ent", "<e2>", "."], "h": {"id": "C0054616", "name": "C0054616#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016295", "name": "C0016295#ent", "pos": [14, 15]}}
{"token": ["Together", ",", "our", "data", "strongly", "imply", "that", "human", "reelin", "and", "GAD67", "C1417679#ent", "<e1>", "are", "coordinately", "regulated", "through", "epigenetic", "mechanisms", "include", "the", "action", "of", "C1621352#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1621352", "name": "C1621352#ent", "pos": [23, 24]}}
{"token": ["We", "further", "demonstrated", "that", "the", "activation", "of", "these", "two", "C1417679#ent", "<e1>", "correlated", "with", "a", "reduction", "in", "DNA", "methyl-transferase", "and", "DNA", "methyltransferase", "1", "C1621352#ent", "<e2>", ")", "protein", "levels"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1621352", "name": "C1621352#ent", "pos": [22, 23]}}
{"token": ["A", "high-performance", "liquid", "chromatographic", "method", "described", "for", "the", "simultaneous", "determination", "of", "the", "anti-inflammatory", "agent", "and", "its", "metabolites", ",", "C0030078#ent", "<e1>", ",", "phenylbutazone", ",", "oxyphenbutazone", ",", "and", "C0030078#ent", "<e1>", ",", "in", "plasma", "and", "urine", "."], "h": {"id": "C0030078", "name": "C0030078#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030078", "name": "C0030078#ent", "pos": [18, 19]}}
{"token": ["C0024977#ent", "<e1>", "is", "chemically", "unrelated", "to", "the", "C0031399#ent", "<e2>", "and", "has", "not", "shown", "the", "side-effects", "or", "abuse", "potential", "of", "the", "amphetamine", "anorectics", "."], "h": {"id": "C0024977", "name": "C0024977#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031399", "name": "C0031399#ent", "pos": [7, 8]}}
{"token": ["C0024977#ent", "<e1>", ",", "a", "new", "anorexigenic", "agent", "possesses", "a", "different", "chemical", "structure", "C0031399#ent", "<e2>", "as", "amphetamine", ",", "causes", "anorexia", "along", "with", "increases", "in", "locomotor", "activity", "body", "temperature"], "h": {"id": "C0024977", "name": "C0024977#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031399", "name": "C0031399#ent", "pos": [12, 13]}}
{"token": ["Recent", "studies", "have", "revealed", "that", "the", "C3810562#ent", "<e1>", "HFE", ")", "interacts", "with", "the", "transferrin", "receptor", "C1705610#ent", "<e2>", ")", "and", "modulates", "TfR-mediated", "iron", "uptake", "by", "cells", "."], "h": {"id": "C3810562", "name": "C3810562#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705610", "name": "C1705610#ent", "pos": [15, 16]}}
{"token": ["Two", "monoclonal", "antibodies", "C0010803#ent", "<e1>", ",", "CAM", "5.2", "and", "C2239920#ent", "<e2>", "34", ",", "were", "used", "to", "determine", "whether", "the", "non-epithelial", "or", "spindle-cell", "components", "of", "each", "tumour", "showed", "evidence", "of", "keratin", "expression", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2239920", "name": "C2239920#ent", "pos": [9, 10]}}
{"token": ["The", "C0010803#ent", "<e1>", "to", "be", "severely", "disturbed", "in", "C2239920#ent", "<e2>", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2239920", "name": "C2239920#ent", "pos": [8, 9]}}
{"token": ["Concomitant", "therapy", "provides", "an", "attractive", "arean", "for", "clinical", "investigation", "particularly", "with", "new", "C0035064#ent", "<e1>", "such", "as", "C0678133#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0678133", "name": "C0678133#ent", "pos": [16, 17]}}
{"token": ["The", "therapeutic", "efficacies", "of", "these", "two", "C0035064#ent", "<e1>", "are", "comparable", "to", "that", "of", "C0678133#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0678133", "name": "C0678133#ent", "pos": [13, 14]}}
{"token": ["Newer", "assays", "show", "19S", "IgM", "RF", "in", "up", "to", "35", "%", "of", "C3714757#ent", "<e1>", "patients", ",", "although", "still", "mainly", "in", "girls", "with", "C1882414#ent", "<e2>"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C1882414", "name": "C1882414#ent", "pos": [22, 23]}}
{"token": ["Our", "studies", "suggest", "that", "activation", "of", "intravascular", "coagulation", "common", "in", "systemic", "onset", "C3714757#ent", "<e1>", ",", "but", "not", "in", "rheumatoid", "factor-negative", "C1882414#ent", "<e2>"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C1882414", "name": "C1882414#ent", "pos": [20, 21]}}
{"token": ["The", "management", "of", "C0038218#ent", "<e1>", "intensive", "pharmacological", "therapy", "with", "beta-adrenoceptor", "agonists", "C0001644#ent", "<e2>", ")", "and", "corticosteroids", "."], "h": {"id": "C0038218", "name": "C0038218#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [11, 12]}}
{"token": ["C0038218#ent", "<e1>", "children", "requires", "aggressive", "treatment", "C0001644#ent", "<e2>", ",", "anticholinergics", ",", "and", "corticosteroids", "."], "h": {"id": "C0038218", "name": "C0038218#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [6, 7]}}
{"token": ["Miltefosine", ",", "an", "C1510852#ent", "<e1>", "been", "found", "effective", "against", "C0023290#ent", "<e2>", "VL", ")", "in", "adults", "in", "various", "studies", "."], "h": {"id": "C1510852", "name": "C1510852#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [9, 10]}}
{"token": ["Miltefosine", ",", "an", "C1510852#ent", "<e1>", ",", "was", "registered", "for", "the", "oral", "treatment", "C0023290#ent", "<e2>", "VL", ")", "in", "India", "in", "March", "2002", "."], "h": {"id": "C1510852", "name": "C1510852#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [12, 13]}}
{"token": ["Stimulation", "with", "PHA", "partially", "nullified", "the", "suppression", "caused", "by", "C0063382#ent", "<e1>", "but", "did", "not", "influence", "the", "effects", "of", "C0025241#ent", "<e2>", "."], "h": {"id": "C0063382", "name": "C0063382#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [18, 19]}}
{"token": ["Physiological", "C0016411#ent", "<e1>", "well", "as", "various", "pharmacological", "vasodilators", "inhibit", "platelet", "function", "activating", "C1382029#ent", "<e2>", "and", "guanylyl", "cyclases", "increasing", "intracellular", "cyclic", "AMP", "cAMP", ")", "and", "cyclic", "GMP", "cGMP", ")", "levels", ",", "respectively", "."], "h": {"id": "C0016411", "name": "C0016411#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [12, 13]}}
{"token": ["Although", "C1705396#ent", "<e1>", "is", "generally", "considered", "an", "C1422492#ent", "<e2>", "and", "Gli3", "a", "repressor", ",", "our", "results", "also", "reveal", "a", "repressor", "function", "C1705396#ent", "<e1>", "and", "an", "activator", "function", "Gli3", "in", "the", "developing", "somite"], "h": {"id": "C1705396", "name": "C1705396#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [7, 8]}}
{"token": ["Taken", "together", ",", "these", "results", "indicate", "that", "C1705396#ent", "<e1>", "mediates", "hedgehog", "signaling", "osteoblasts", "and", "is", "a", "powerful", "C1422492#ent", "<e2>", "of", "BMP-2", "gene", ",", "which", "is", "required", "in", "turn", "for", "normal", "osteoblast", "differentiation", "."], "h": {"id": "C1705396", "name": "C1705396#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [17, 18]}}
{"token": ["The", "current", "review", "is", "focussed", "on", "IgE-dependent", "C3538773#ent", "<e1>", "that", "require", "the", "presence", "of", "certain", "types", "of", "C1415975#ent", "<e2>", "(", "designated", "IgE+", ")", "to", "induce", "histamine", "release", "."], "h": {"id": "C3538773", "name": "C3538773#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "unique", "C0024141#ent", "<e1>", "patient", "with", "an", "C0162429#ent", "<e2>"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [9, 10]}}
{"token": ["The", "toxic", "effects", "mucositis", "(", "48", "patients", ")", ",", "nausea", "(", "25", "patients", ",", "vomiting", "in", "six", "patients", ")", ",", "C0280962#ent", "<e1>", "15", "patients", ")", "and", "C0031117#ent", "<e2>", "14", "patients", ")", "."], "h": {"id": "C0280962", "name": "C0280962#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [26, 27]}}
{"token": ["Third", ",", "complementation", "experiments", "revealed", "that", "coexpression", "of", "two", "distinct", "nonfunctional", "C1332811#ent", "<e1>", "mutants", "can", "rescue", "the", "ubiquitin", "ligase", "function", "the", "C0812385#ent", "<e2>", "complex", "."], "h": {"id": "C1332811", "name": "C1332811#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [21, 22]}}
{"token": ["Recent", "gene", "targeting", "studies", "have", "shed", "light", "on", "the", "importance", "of", "this", "family", "of", "C4284029#ent", "<e1>", "the", "immune", "system", "and", "the", "complex", "mechanisms", "by", "which", "these", "C0031727#ent", "<e2>", "are", "regulated", "in", "vivo"], "h": {"id": "C4284029", "name": "C4284029#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [26, 27]}}
{"token": ["The", "five", "groups", "were", "cerebral", "childhood", "adolescent", ",", "pure", "adrenomyeloneuropathy", "pure", "AMN", ")", ",", "C0162309#ent", "<e1>", "AMN", "cerebral", ")", ",", "C0001403#ent", "<e2>", "and", "symptomatic", "female", "heterozygotes", "."], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [20, 21]}}
{"token": ["X-linked", "adrenoleukodystrophy", "C0162309#ent", "<e1>", ")", "is", "characterised", "by", "progressive", "multifocal", "demyelination", "central", "nervous", "system", "C0001403#ent", "<e2>"], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [14, 15]}}
{"token": ["Regeneration", "was", "synchronized", "by", "reversible", "inhibition", "of", "C0035547#ent", "<e1>", "10", "h", "treatment", "with", "C0020402#ent", "<e2>", "(", "HU", ")", "shortly", "after", "two-third", "partial", "hepatectomy", "."], "h": {"id": "C0035547", "name": "C0035547#ent", "pos": [7, 8]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [13, 14]}}
{"token": ["Assay", "of", "C0035547#ent", "<e1>", "in", "intact", "virus-infected", "cells", "suggested", "that", "C0020402#ent", "<e2>", "may", "differentially", "affect", "reduction", "of", "the", "various", "substrates", "of", "the", "enzyme", "."], "h": {"id": "C0035547", "name": "C0035547#ent", "pos": [2, 3]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [10, 11]}}
{"token": ["The", "most", "logical", "explanation", "for", "these", "results", "is", "that", "the", "mutant", "cells", "a", "structurally", "altered", "C0035547#ent", "<e1>", "activity", "is", "less", "sensitive", "to", "inhibition", "by", "C0020402#ent", "<e2>", "or", "guanazole", "."], "h": {"id": "C0035547", "name": "C0035547#ent", "pos": [15, 16]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [24, 25]}}
{"token": ["The", "direct", "binding", "of", "C1412931#ent", "<e1>", "to", "C0079556#ent", "<e2>", "was", "confirmed", "by", "comigration", "of", "C1412931#ent", "<e1>", "with", "HTLV-I", "virion", "upon", "sucrose", "density", "gradient", "ultracentrifugation", "C0079556#ent", "<e2>", "virion", "treated", "with", "C1412931#ent", "<e1>", "."], "h": {"id": "C1412931", "name": "C1412931#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079556", "name": "C0079556#ent", "pos": [7, 8]}}
{"token": ["Substance", "P", "forskolin", "and", "C0022245#ent", "<e1>", "stimulated", "rat", "parotid", "C0002245#ent", "<e2>", "in", "vitro"], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [9, 10]}}
{"token": ["At", "the", "infusion", "rate", "of", "2.5", "micrograms/kg/min", ",", "C0022245#ent", "<e1>", "caused", "nonuniform", "reductions", "in", "ATP", ",", "phosphocreatine", ",", "total", "adenine", "nucleotides", "C0002245#ent", "<e2>", ",", "which", "were", "particularly", "depleted", "in", "the", "endocardium", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [21, 22]}}
{"token": ["Glucagon", ",", "epinephrine", ",", "norepinephrine", ",", "C0022245#ent", "<e1>", "and", "phenylephrine", "each", "increases", "significantly", "glucose", "appearance", "and", "C0002245#ent", "<e2>", "disappearance", "from", "hepatocytes", "of", "both", "juvenile", "and", "adult", "fed", "rabbits", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [16, 17]}}
{"token": ["Kinase", "activation", "determined", "by", "the", "activity", "ratio", "method", ",", "was", "measurably", "increased", "by", "C0022245#ent", "<e1>", ",", "a", "beta-adrenergic", "agonist", "a", "potent", "stimulator", "of", "C0002245#ent", "<e2>", "(", "EC", "3.2.1.1", "secretion", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [23, 24]}}
{"token": ["In", "C0156147#ent", "<e1>", "neurologic", "complications", "as", "cerebrovascular", "accident", "headache", ",", "C0031117#ent", "<e2>", "been", "reported", "sporadically", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [10, 11]}}
{"token": ["We", "report", "the", "case", "of", "a", "young", "woman", "with", "C0156147#ent", "<e1>", "developed", "a", "debilitating", "C0031117#ent", "<e2>", "treated", "with", "metronidazole", "2000", "mg/d", "for", "50", "days", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [14, 15]}}
{"token": ["To", "report", "a", "case", "of", "seizures", "in", "a", "patient", "with", "C0002395#ent", "<e1>", "who", "was", "receiving", "C0123091#ent", "<e2>", "for", "psychoses", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0123091", "name": "C0123091#ent", "pos": [15, 16]}}
{"token": ["C1847555#ent", "<e1>", "characterized", "by", "recurrent", "and", "symptomatic", "C0020616#ent", "<e2>", "in", "childhood", ",", "secondary", "to", "hyperinsulinism", "associated", "with", "mild", "and", "asymptomatic", "hyperammonemia", "."], "h": {"id": "C1847555", "name": "C1847555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [7, 8]}}
{"token": ["Unexpectedly", ",", "knockdown", "of", "C1333897#ent", "<e1>", "induced", "parallel", "knockdown", "of", "C1366587#ent", "<e2>", "mRNA", "and", "protein", "expression", "whereas", "C1366587#ent", "<e2>", "knockdown", "had", "no", "noticeable", "effect", "on", "C1333897#ent", "<e1>", "expression", "."], "h": {"id": "C1366587", "name": "C1366587#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [4, 5]}}
{"token": ["Maternal", "complications", "C0042029#ent", "<e1>", "hypertension", ",", "proteinuria", ",", "C0013604#ent", "<e2>", ",", "deterioration", "in", "renal", "function", "hematuria", "or", "renal", "stones", "occurred", "alone", "or", "in", "combination", "in", "39", "%", "of", "pregnancies", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [8, 9]}}
{"token": ["It", "seems", "likely", "that", "a", "non-specific", "effect", "C0042029#ent", "<e1>", ",", "such", "as", "C0013604#ent", "<e2>", "is", "responsible", "for", "this", "acquired", "VUR", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [12, 13]}}
{"token": ["When", "tranylcypromine", "(", "C0701426#ent", "<e1>", ")", ",", "an", "inhibitor", "of", "C0026454#ent", "<e2>", "was", "added", "to", "the", "perfusion", "fluid", "perfusion", "was", "continued", ",", "the", "5-HT", "output", "increased", "."], "h": {"id": "C0701426", "name": "C0701426#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [10, 11]}}
{"token": ["Severe", "intoxication", "with", "the", "C1422070#ent", "<e1>", "substrate", "ivermectin", "has", "been", "attributed", "to", "the", "C1516876#ent", "<e2>", "determined", "lack", "of", "C1422070#ent", "<e1>", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [4, 5]}}
{"token": ["A", "host", "of", "disease", "processes", "are", "recognized", "to", "be", "complicated", "by", "zinc", "deficiency", "C0023896#ent", "<e1>", "sickle", "cell", "anemia", "protein", "calorie", "malnutrition", "and", "a", "variety", "of", "C0021831#ent", "<e2>", "Crohn's", "disease", "sprue", ",", "short", "bowel", "syndrome", "after", "jejunal", "ileal", "bypass"], "h": {"id": "C0023896", "name": "C0023896#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [25, 26]}}
{"token": ["The", "signs", "of", "inflammation", "(", "ascites", ",", "C0013604#ent", "<e1>", ")", "in", "chicks", "receiving", "actinomycin", "D", "disappeared", "with", "C0032950#ent", "<e2>", "premedication", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [17, 18]}}
{"token": ["Among", "those", "compounds", "tested", ",", "FP16CM", "showed", "the", "highest", "activities", "in", "receptor", "binding", "NO", "inhibition", "and", "C0013604#ent", "<e1>", "these", "activities", "were", "comparable", "to", "those", "of", "C0032950#ent", "<e2>", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [25, 26]}}
{"token": ["Due", "to", "a", "suspicion", "of", "post", "C0013604#ent", "<e1>", "the", "patient", "was", "treated", "with", "C0032950#ent", "<e2>", ",", "but", "the", "progression", "of", "the", "lesion", "could", "not", "be", "arrested", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [13, 14]}}
{"token": ["To", "explore", "the", "effects", "of", "olmesartan", "on", "frequency", "and", "severity", "of", "C0149931#ent", "<e1>", "attacks", "in", "patients", "with", "comorbid", "hypertension", "C1696708#ent", "<e2>", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1696708", "name": "C1696708#ent", "pos": [19, 20]}}
{"token": ["C1425943#ent", "<e1>", "is", "strongly", "induced", "by", "C0022265#ent", "<e2>", "F9", "and", "P19", "embryonal", "carcinoma", "cells"], "h": {"id": "C1425943", "name": "C1425943#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [6, 7]}}
{"token": ["Present", "knowledge", "of", "experimental", "infection", "non-human", "primates", "with", "variola", "virus", "of", "a", "related", "C0042769#ent", "<e1>", "monkeys", ",", "termed", "C0276180#ent", "<e2>", ",", "is", "examined", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0276180", "name": "C0276180#ent", "pos": [18, 19]}}
{"token": ["These", "include", "other", "acute", "emerging", "or", "re-emerging", "C0042769#ent", "<e1>", "as", "severe", "acute", "respiratory", "syndrome", "SARS", ")", ",", "West-Nile", "virus", "Ebola", "virus", "C0276180#ent", "<e2>", ",", "as", "well", "as", "the", "more", "inapparent", "insidious", "slow", "viral", "and", "prion", "diseases"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0276180", "name": "C0276180#ent", "pos": [21, 22]}}
{"token": ["Uniquely", "among", "condensing", "enzymes", "3-hydroxy-3-methylglutaryl", "(HMG)-CoA", "synthase", "HMGS", ")", "catalyzes", "the", "formation", "of", "a", "C0524928#ent", "<e1>", "activating", "the", "methyl", "group", "an", "C0001047#ent", "<e2>"], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [21, 22]}}
{"token": ["Examination", "of", "the", "expression", "of", "C1332324#ent", "<e1>", "that", "hesperidin", "treatment", "decreased", "the", "expression", "of", "B-cell", "CLL/lymphoma", "2", "C4042483#ent", "<e2>", ")", "mRNA", ",", "and", "increased", "the", "expression", "of", "BCL2-associated", "X", "protein", "BAX", ")", "."], "h": {"id": "C1332324", "name": "C1332324#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4042483", "name": "C4042483#ent", "pos": [17, 18]}}
{"token": ["This", "calpain", "stimulation", "of", "C1382029#ent", "<e1>", "inhibited", "by", "an", "antibody", "raised", "against", "the", "C-terminal", "portion", "C0086903#ent", "<e2>", ",", "but", "not", "by", "anti-G(i)2alpha", "or", "anti-Gbeta", "antibodies", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [15, 16]}}
{"token": ["CGS-21680", "and", "2-chloroadenosine", "(", "CAD", ")", "stimulated", "C1382029#ent", "<e1>", "a", "concentration-dependent", "fashion", "which", "was", "blocked", "significantly", "by", "C0086903#ent", "<e2>"], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [17, 18]}}
{"token": ["There", "was", "no", "evidence", "of", "any", "aetiology", "apart", "from", "the", "exposure", "to", "antidepressant", "drug", "nefazodone", ",", "while", "the", "results", "of", "repeated", "histological", "examinations", "the", "C0023899#ent", "<e1>", "were", "compatible", "with", "serious", "progressive", "C1262760#ent", "<e2>"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1262760", "name": "C1262760#ent", "pos": [31, 32]}}
{"token": ["DCs", "may", "be", "less", "activated", "with", "therapy", ",", "as", "suggested", "by", "decreased", "C1881122#ent", "<e1>", "mRNA", "and", "inducible", "C0132555#ent", "<e2>", "mRNA", "and", "protein", "."], "h": {"id": "C1881122", "name": "C1881122#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [17, 18]}}
{"token": ["We", "present", "a", "15-year-old", "woman", "with", "acute", "myelomonocytic", "leukemia", "C0014457#ent", "<e1>", "M4", "in", "the", "C2828027#ent", "<e2>", "classification", "."], "h": {"id": "C0014457", "name": "C0014457#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2828027", "name": "C2828027#ent", "pos": [14, 15]}}
{"token": ["Hemolysates", "were", "typed", "for", "C0022173#ent", "<e1>", "of", "ESD", ",", "PGM1", ",", "ADA", ",", "AK1", ",", "C1415104#ent", "<e2>", ",", "ACP1", ",", "and", "GPI", "using", "standard", "electrophoretic", "techniques"], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415104", "name": "C1415104#ent", "pos": [15, 16]}}
{"token": ["In", "dissociated", "granule", "neurons", "and", "cerebellar", "slice", "recordings", ",", "C0700541#ent", "<e1>", "potentiated", "the", "GABAergic", "conductance", "arising", "from", "alpha6-containing", "GABA(A)", "receptors", "whereas", "C0031381#ent", "<e2>", "showed", "no", "effect"], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [21, 22]}}
{"token": ["We", "conclude", "that", "the", "analgesic", "effect", "C0700541#ent", "<e1>", "in", "humans", "is", "most", "probably", "mediated", "via", "C0031381#ent", "<e2>", "although", "a", "kappa", "effect", "can", "not", "be", "excluded", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [15, 16]}}
{"token": ["To", "study", "the", "nucleic", "acid-binding", "of", "C1418220#ent", "<e1>", ",", "a", "protein", "with", "multiple", "repeats", "a", "C3273678#ent", "<e2>", "we", "expressed", "the", "long", "splicing", "in", "a", "eukaryotic", "cell", "line", "purified", "it", "in", "native", "form", "."], "h": {"id": "C1418220", "name": "C1418220#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273678", "name": "C3273678#ent", "pos": [15, 16]}}
{"token": ["In", "Xenopus", "embryos", "treated", "with", "RA", ",", "C1334043#ent", "<e1>", "of", "the", "C1540289#ent", "<e2>", "displayed", "a", "temporal", "and", "dose", "response", "with", "gene", "organisation"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1540289", "name": "C1540289#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "on", "renal", "function", "quinapril", ",", "an", "angiotensin", "I", "converting", "enzyme", "ACE", ")", "inhibitor", ",", "and", "of", "nifedipine", ",", "a", "C0006684#ent", "<e1>", "were", "studied", "in", "the", "early", "stages", "C0011849#ent", "<e2>", "in", "rats", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [29, 30]}}
{"token": ["40", "-", "70", "%", "of", "C0017978#ent", "<e1>", "in", "sphingolipid-enriched", "membrane", "domains", ",", "with", "the", "maximum", "C0017082#ent", "<e2>", "fully", "differentiated", "neurons", "."], "h": {"id": "C0017978", "name": "C0017978#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017082", "name": "C0017082#ent", "pos": [15, 16]}}
{"token": ["These", "results", "would", "suggest", "that", "acrolein", ",", "although", "apparently", "not", "mutagenic", ",", "mediates", "the", "teratogenicity", "of", "C0067359#ent", "<e1>", "and", "a", "significant", "proportion", "of", "the", "teratogenicity", "of", "C1161438#ent", "<e2>", "."], "h": {"id": "C0067359", "name": "C0067359#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [26, 27]}}
{"token": ["If", "acrolein", "is", "responsible", "for", "the", "teratogenic", "effects", "C0067359#ent", "<e1>", ",", "the", "other", "major", "cytotoxic", "metabolite", "C1161438#ent", "<e2>", ",", "phosphoramide", "mustard", "may", "account", "for", "the", "difference", "in", "teratogenic", "potency", "between", "C1161438#ent", "<e2>", "and", "C0067359#ent", "<e1>", "."], "h": {"id": "C0067359", "name": "C0067359#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [16, 17]}}
{"token": ["The", "results", "provide", "evidence", "that", "clearance", "of", "C0600260#ent", "<e1>", "material", "is", "crucial", "in", "managing", "C0035220#ent", "<e2>", "from", "combined", "burn", "and", "smoke", "inhalation", "injury"], "h": {"id": "C0600260", "name": "C0600260#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [14, 15]}}
{"token": ["Mutations", "of", "lamin", "A/C", "LMNA", ")", "cause", "a", "wide", "range", "of", "human", "disorders", "including", "progeria", ",", "C0023787#ent", "<e1>", ",", "neuropathies", "and", "autosomal", "dominant", "C0410190#ent", "<e2>", "EDMD", ")", "."], "h": {"id": "C0023787", "name": "C0023787#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0410190", "name": "C0410190#ent", "pos": [23, 24]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "examine", "the", "effects", "of", "combined", "oral", "treatment", "C0751039#ent", "<e1>", "and", "nifedipine", "or", "C0282138#ent", "<e2>", "on", "the", "severity", "of", "gingival", "overgrowth", "rats", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "suggest", "that", "C0751039#ent", "<e1>", "induced", "acute", "vasoconstriction", "renal", "hypoperfusion", "mediated", "by", "ET-1", "and", "that", "C0282138#ent", "<e2>", "treatment", "abolishes", "these", "pharmacodynamic", "effects", "C0751039#ent", "<e1>", "despite", "persistent", "increase", "of", "plasma", "ET-1", "levels", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [16, 17]}}
{"token": ["Tissue", "plasminogen", "activator", "C0032143#ent", "<e1>", ")", "in", "plasma", "obtained", "from", "patients", "with", "acute", "hepatitis", "C0524909#ent", "<e2>", "liver", "cirrhosis", "hepatocellular", "carcinoma", "drug-induced", "intrahepatic", "cholestasis", "obstructive", "jaundice", "fulminant", "hepatitis", "disseminated", "intravascular", "coagulation", "DIC", ")", ",", "was", "analysed", "chromatographically", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [14, 15]}}
{"token": ["Significant", "reductions", "in", "tumor", "yield", "were", "also", "observed", "when", "C0056289#ent", "<e1>", "was", "applied", "prior", "to", "C0058272#ent", "<e2>", "in", "either", "of", "the", "complete", "carcinogenesis", "protocols", "."], "h": {"id": "C0056289", "name": "C0056289#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0058272", "name": "C0058272#ent", "pos": [15, 16]}}
{"token": ["In", "terms", "of", "skin", "tumor", "initiation", ",", "BHT", ",", "vitamin", "E", "C", "and", "C0056289#ent", "<e1>", "have", "been", "found", "to", "inhibit", "C0058272#ent", "<e2>", "skin", "tumor", "initiation", "by", "approximately", "50", "%", "."], "h": {"id": "C0056289", "name": "C0056289#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0058272", "name": "C0058272#ent", "pos": [20, 21]}}
{"token": ["The", "effects", "of", "C0036572#ent", "<e1>", "lidocaine", "and", "C0887621#ent", "<e2>", "administered", "intravenously", "(", "i.v", ".", ")"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0887621", "name": "C0887621#ent", "pos": [7, 8]}}
{"token": ["The", "cumulative", "doses", "levobupivacaine", "and", "ropivacaine", "that", "produced", "C0036572#ent", "<e1>", "were", "similar", "and", "were", "larger", "than", "those", "of", "C0887621#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0887621", "name": "C0887621#ent", "pos": [18, 19]}}
{"token": ["The", "developmental", "toxicity", "of", "the", "C2975999#ent", "<e1>", "HMG-CoA", ")", "reductase", "inhibitor", ",", "C0286651#ent", "<e2>", ",", "was", "investigated", "in", "pregnant", "rats", "and", "rabbits", "given", "daily", "oral", "doses", "organogenesis", "."], "h": {"id": "C2975999", "name": "C2975999#ent", "pos": [5, 6]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0286651", "name": "C0286651#ent", "pos": [12, 13]}}
{"token": ["Further", ",", "we", "suggest", "a", "role", "for", "C1704883#ent", "<e1>", "in", "early", "tumour", "progression", "expression", "of", "C2001899#ent", "<e2>", "during", "metastasis", "and", "focal", "expression", "pattern", "of", "MMP-3", "in", "areas", "of", "expansion", "."], "h": {"id": "C1704883", "name": "C1704883#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [15, 16]}}
{"token": ["ECM", "inducer", "protein", "EMMPRIN", ")", "and", "MMP", "activator", "membrane-type", "MMP", "C1704883#ent", "<e1>", ")", ",", "as", "well", "as", "C2001899#ent", "<e2>", ",", "-2", ",", "and", "-9", ",", "were", "quantified", "by", "immunoblotting", "and", "densitometry", "(", "pixels", ")", "."], "h": {"id": "C1704883", "name": "C1704883#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [17, 18]}}
{"token": ["The", "results", "in", "the", "study", "group", "compared", "with", "the", "results", "in", "the", "patients", "without", "C0011847#ent", "<e1>", "who", "had", "C1420751#ent", "<e2>", "during", "the", "same", "period", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420751", "name": "C1420751#ent", "pos": [18, 19]}}
{"token": ["Taken", "together", ",", "we", "propose", "that", "C0026267#ent", "<e1>", ",", "most", "likely", "through", "its", "interaction", "with", "C1538830#ent", "<e2>", ",", "suppresses", "c-Jun-mediated", "AP-1", "transcription", "unstressed", "conditions", ",", "thereby", "preventing", "cells", "from", "undergoing", "stress", "response"], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538830", "name": "C1538830#ent", "pos": [15, 16]}}
{"token": ["To", "develop", "a", "rapid", "diagnostic", "approach", "individuals", "with", "the", "X-linked", "cytomegalic", "of", "adrenal", "hypoplasia", "congenita", "AHC", ")", "and", "hypogonadotropic", "hypogonadism", "C0062941#ent", "<e1>", ")", "due", "to", "mutations", "in", "C2698419#ent", "<e2>", ",", "a", "new", "member", "of", "the", "nuclear", "hormone", "receptor", "gene", "superfamily"], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2698419", "name": "C2698419#ent", "pos": [27, 28]}}
{"token": ["The", "expression", "of", "DAX-1", "in", "the", "neuroendocrine", "system", "that", "interruption", "of", "the", "expression", "in", "these", "tissues", "may", "be", "the", "cause", "of", "the", "hypogonadotropic", "hypogonadism", "C0062941#ent", "<e1>", ")", "that", "is", "frequently", "associated", "with", "C2698419#ent", "<e2>", "."], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C2698419", "name": "C2698419#ent", "pos": [32, 33]}}
{"token": ["Dermatologists", "consulted", "by", "a", "patient", "with", "the", "C0406656#ent", "<e1>", "be", "aware", "of", "the", "possibility", "of", "an", "associated", "C0035435#ent", "<e2>"], "h": {"id": "C0406656", "name": "C0406656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [17, 18]}}
{"token": ["The", "lack", "of", "correlation", "between", "the", "changes", "in", "two", "acute", "phase", "reactants", "C1439335#ent", "<e1>", "different", "underlying", "mechanisms", "for", "the", "effects", "of", "estrogen", "on", "these", "C0003762#ent", "<e2>"], "h": {"id": "C1439335", "name": "C1439335#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003762", "name": "C0003762#ent", "pos": [24, 25]}}
{"token": ["The", "differential", "magnitude", "of", "the", "C0087140#ent", "<e1>", "mRNA", "response", "the", "NTS", ",", "PBN", ",", "CeA", "and", "C2987232#ent", "<e2>", "is", "consistent", "with", "vagal", "activation"], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987232", "name": "C2987232#ent", "pos": [16, 17]}}
{"token": ["Although", "footshock", "induced", "C0087140#ent", "<e1>", "mRNA", "expression", "in", "the", "C2987232#ent", "<e2>", ",", "its", "effects", "in", "this", "region", "were", "not", "dependent", "on", "drug", "history"], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987232", "name": "C2987232#ent", "pos": [9, 10]}}
{"token": ["Parturition", "significantly", "increased", "the", "number", "of", "double-immunolabeled", "cells", "for", "C0087140#ent", "<e1>", "and", "OTR", "within", "the", "SON", ",", "brainstem", ",", "C2987232#ent", "<e2>", ",", "and", "mPOA", "regions", "compared", "with", "virgin", "rats", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987232", "name": "C2987232#ent", "pos": [19, 20]}}
{"token": ["Moreover", ",", "4", "of", "the", "5", "cases", "showed", "a", "mild", "elevation", "C0004002#ent", "<e1>", "the", "same", "period", ",", "and", "other", "C0042769#ent", "<e2>", "cytomegalovirus", ",", "Epstein-Barr", "virus", "and", "human", "herpesvirus", "7", "ruled", "out", "in", "these", "patients", "."], "h": {"id": "C0004002", "name": "C0004002#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [19, 20]}}
{"token": ["Mucosal", "leishmaniasis", "C1705224#ent", "<e1>", ")", "is", "an", "important", "complication", "of", "new", "world", "C0276878#ent", "<e2>", "CL", ")", "caused", "by", "species", "of", "the", "Leishmania", "Viannia", "subgenus"], "h": {"id": "C1705224", "name": "C1705224#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0276878", "name": "C0276878#ent", "pos": [12, 13]}}
{"token": ["The", "other", "two", "groups", "are", "C1334043#ent", "<e1>", "to", "the", "nonspecific", "cross-reacting", "antigen", "C1413309#ent", "<e2>", ")", "and", "biliary", "glycoprotein", "BGP", ")", ",", "both", "of", "which", "are", "members", "of", "the", "carcinoembryonic", "antigen", "CEA", ")", "family", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [12, 13]}}
{"token": ["These", "regions", "are", "C1334043#ent", "<e1>", "in", "the", "various", "vertebrate", "metallothioneins", "known", "to", "C1413309#ent", "<e2>", "with", "rabbit", "anti-rat", "metallothionein", "antiserum", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [12, 13]}}
{"token": ["When", "boosted", "with", "an", "appropriate", "mixture", "of", "both", "antigens", ",", "the", "response", "is", "of", "standard", "secondary", "type", "the", "C1334043#ent", "<e1>", "followed", "by", "a", "standard", "primary", "response", "the", "C1413309#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [27, 28]}}
{"token": ["This", "results", "in", "C0339143#ent", "<e1>", ",", "most", "often", "the", "syndrome", "originally", "reported", "by", "C0016724#ent", "<e2>", ",", "with", "failure", "of", "sexual", "maturation", "obesity", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016724", "name": "C0016724#ent", "pos": [13, 14]}}
{"token": ["To", "investigate", "the", "function", "of", "islet", "beta", "cells", "subjects", "with", "normal", "glucose", "tolerance", "NGT", ")", ",", "C0271650#ent", "<e1>", "IGR", ")", ",", "and", "C0011854#ent", "<e2>", "T2DM", ")", "."], "h": {"id": "C0271650", "name": "C0271650#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [22, 23]}}
{"token": ["The", "main", "conclusions", "of", "DCCT", "proved", "that", "correct", "metabolic", "control", "reduces", "the", "risk", "of", "C0271650#ent", "<e1>", "and", "to", "the", "majority", "of", "patients", "with", "C0011854#ent", "<e2>", "intensified", "treatment", "should", "be", "recommended", "."], "h": {"id": "C0271650", "name": "C0271650#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [23, 24]}}
{"token": ["Of", "these", "the", "greater", "density", "of", "C1439306#ent", "<e1>", "the", "presence", "of", "C1567075#ent", "<e2>", "differentiates", "tumors", "from", "the", "nontumor", "tissues"], "h": {"id": "C1439306", "name": "C1439306#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1567075", "name": "C1567075#ent", "pos": [11, 12]}}
{"token": ["On", "the", "clinical", "ground", "C0040261#ent", "<e1>", "24.56", "%", ")", "was", "predominant", ",", "with", "C0040252#ent", "<e2>", "23.68", "%", ")", "and", "also", "tinea", "capitis", "2192", "%", ")", "."], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040252", "name": "C0040252#ent", "pos": [13, 14]}}
{"token": ["Because", "the", "C0919429#ent", "<e1>", "highly", "polymorphic", "at", "codon", "89", ",", "two", "C0039602#ent", "<e2>", "isoforms", "are", "expressed", "that", "differ", "in", "K(m", ")", "and", "V(max", ")", "values", "."], "h": {"id": "C0919429", "name": "C0919429#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0039602", "name": "C0039602#ent", "pos": [11, 12]}}
{"token": ["Our", "study", "revealed", "that", "the", "composition", "of", "SC", "lipids", "in", "the", "anesthetic", "lesions", "leprosy", "patients", "was", "higher", "in", "C0052456#ent", "<e1>", "triglycerides", "and", "lower", "in", "C0017978#ent", "<e2>", "and", "cholesterol", "esters", "that", "of", "normal", "subjects"], "h": {"id": "C0052456", "name": "C0052456#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017978", "name": "C0017978#ent", "pos": [24, 25]}}
{"token": ["These", "results", "suggest", "that", "transduction", "of", "C1519061#ent", "<e1>", "analogs", "of", "HSP20", "directly", "C2712370#ent", "<e2>", "physiological", "responses", "intact", "muscles", "."], "h": {"id": "C1519061", "name": "C1519061#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [12, 13]}}
{"token": ["Therefore", ",", "targeting", "either", "C1709384#ent", "<e1>", "or", "histone", "H2AX", "provide", "an", "effective", "way", "of", "maximizing", "the", "C0003392#ent", "<e2>", "alkylating", "agents", "cancer", "treatment"], "h": {"id": "C1709384", "name": "C1709384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [16, 17]}}
{"token": ["In", "4", "of", "5", "RVP", "patients", "with", "C0029443#ent", "<e1>", "yet", "in", "none", "of", "7", "C1567075#ent", "<e2>", "cases", "some", "restoration", "of", "osteolytic", "lesions", "seen", "."], "h": {"id": "C0029443", "name": "C0029443#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1567075", "name": "C1567075#ent", "pos": [14, 15]}}
{"token": ["By", "nanoelectrospray", "mass", "spectrometry", "we", "identified", "C1413966#ent", "<e1>", "RHA", ")", "as", "an", "C4283936#ent", "<e2>", "complex-associated", "protein"], "h": {"id": "C1413966", "name": "C1413966#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4283936", "name": "C4283936#ent", "pos": [12, 13]}}
{"token": ["These", "data", "suggest", "that", "it", "is", "unlikely", "that", "C0051124#ent", "<e1>", "cause", "increases", "in", "C0380393#ent", "<e2>", "exposure", "in", "the", "clinic", "."], "h": {"id": "C0051124", "name": "C0051124#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0380393", "name": "C0380393#ent", "pos": [13, 14]}}
{"token": ["Based", "on", "this", ",", "we", "hypothesize", "that", "C1416865#ent", "<e1>", "may", "function", "as", "a", "secretion", "C1332924#ent", "<e2>", "in", "EPEC", "."], "h": {"id": "C1416865", "name": "C1416865#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332924", "name": "C1332924#ent", "pos": [14, 15]}}
{"token": ["This", "study", "also", "revealed", "that", "the", "down-regulation", "of", "the", "MCP-1", "mRNA", "expression", "by", "C0011816#ent", "<e1>", "in", "activated", "microglial", "cells", "mediated", "via", "C0170168#ent", "<e2>", "MAPK", ")", "pathways", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "both", "IL-6", "and", "IFN-alpha", "blocked", "C0011816#ent", "<e1>", "plus", "alphaIGF-1R-induced", "apoptosis", "through", "activation", "of", "the", "C0170168#ent", "<e2>", "phosphatidylinositol", "3-kinase", "pathways"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [16, 17]}}
{"token": ["In", "HIB5", ",", "pre-treatment", "with", "dexamethasone", "(", "C0011816#ent", "<e1>", ")", "alone", "inhibited", "neurite", "outgrowth", "abolished", "activation", "of", "the", "C0170168#ent", "<e2>", "MAPK", ")", "pathway", "during", "platelet-derived", "growth", "factor", "differentiation", ",", "consistent", "with", "findings", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [18, 19]}}
{"token": ["A", "similarly", "affected", "female", "with", "left", "anterior", "hemiblock", "complete", "atrioventricular", "block", "age", "26", "years", ",", "Despite", "the", "ultrastructural", "changes", ",", "clinically", "detectable", "C0878544#ent", "<e1>", "not", "a", "feature", "of", "C0022541#ent", "<e2>"], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [22, 23]}, "relation": "manifestation_of", "t": {"id": "C0022541", "name": "C0022541#ent", "pos": [28, 29]}}
{"token": ["RT-PCR", "suggested", "that", "both", "C1413285#ent", "<e1>", "and", "P40", "mRNA", "are", "expressed", "in", "HepG2", "cell", "secreting", "C1367597#ent", "<e2>", ",", "in", "contrast", ",", "neither", "C1413285#ent", "<e1>", "mRNA", "nor", "P40", "m", "RNA", "was", "expressed", "in", "non-secreting", "alpha-fetoprotein", "cell", "lines"], "h": {"id": "C1413285", "name": "C1413285#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367597", "name": "C1367597#ent", "pos": [15, 16]}}
{"token": ["RT-PCR", "suggested", "that", "both", "C1413285#ent", "<e1>", "and", "P40", "mRNA", "are", "expressed", "in", "HepG2", "cell", "secreting", "alpha-fetoprotein", ",", "in", "contrast", ",", "neither", "C1413285#ent", "<e1>", "mRNA", "nor", "P40", "m", "RNA", "was", "expressed", "in", "non-secreting", "C1367597#ent", "<e1>"], "h": {"id": "C1413285", "name": "C1413285#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367597", "name": "C1367597#ent", "pos": [32, 33]}}
{"token": ["We", "have", "previously", "found", "decreased", "C0960580#ent", "<e1>", "Tanzanians", "tested", "with", "C0031507#ent", "<e2>", "and", "omeprazole", "in", "relation", "to", "genotype", "when", "compared", "with", "white", "and", "Asian", "subjects", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [10, 11]}}
{"token": ["To", "clarify", "the", "effect", "of", "genetic", "polymorphism", "C0960580#ent", "<e1>", "on", "pharmacokinetics", "of", "C0031507#ent", "<e2>", "and", "phenobarbital", "using", "a", "Non-linear", "Mixed", "Effects", "Modelling", "analysis", "in", "Japanese", "epileptic", "patients", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "assessed", "the", "effect", "of", "C0717550#ent", "<e1>", "cilexetil", "on", "microalbuminuria", "in", "patients", "with", "type", "II", "diabetes", "mellitus", "C0020538#ent", "<e2>"], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [21, 22]}}
{"token": ["Cocrystallographic", "studies", "SU6668", "in", "the", "catalytic", "domain", "C1333542#ent", "<e1>", "the", "adenine", "mimetic", "properties", "of", "its", "C0021236#ent", "<e2>", "core", "."], "h": {"id": "C1333542", "name": "C1333542#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021236", "name": "C0021236#ent", "pos": [15, 16]}}
{"token": ["Studies", "with", "the", "calcium", "ionophore", "ionomycin", "C0043838#ent", "<e1>", ",", "and", "the", "protein", "kinase", "inhibitor", "C0075193#ent", "<e2>", "indicate", "that", "both", "protein", "kinase", "C-dependent", "protein", "kinase", "C-independent", "staurosporine-insensitive", ")", "mechanisms", "mediate", "heterologous", "desensitization", "after", "mIg", "crosslinking"], "h": {"id": "C0043838", "name": "C0043838#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "neutrophils", "stimulated", "with", "7.8", "microM", "C0043838#ent", "<e1>", "in", "the", "presence", "of", "C0075193#ent", "<e2>", "release", "large", "quantities", "of", "O2-", "without", "an", "enhanced", "phosphorylation", "of", "the", "47-", "and", "the", "49-kDa", "proteins", "."], "h": {"id": "C0043838", "name": "C0043838#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [13, 14]}}
{"token": ["C0022735#ent", "<e1>", "HHG", ")", "also", "may", "be", "associated", "with", "C2698419#ent", "<e2>", "."], "h": {"id": "C0022735", "name": "C0022735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2698419", "name": "C2698419#ent", "pos": [9, 10]}}
{"token": ["C0022735#ent", "<e1>", "frequently", "associated", "with", "disease", "and", "the", "C2698419#ent", "<e2>", "mutation", "is", "known", "to", "impair", "gonadotrophin", "production", "by", "acting", "at", "both", "the", "hypothalamic", "and", "pituitary", "levels"], "h": {"id": "C0022735", "name": "C0022735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2698419", "name": "C2698419#ent", "pos": [8, 9]}}
{"token": ["As", "nasal", "endoscopy", "high", "resolution", "C3813556#ent", "<e1>", "is", "a", "part", "of", "the", "C0149516#ent", "<e2>", "pre-operative", "assessment", "."], "h": {"id": "C3813556", "name": "C3813556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149516", "name": "C0149516#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "the", "expression", "of", "the", "C1704888#ent", "<e1>", "and", "SCF", "C1417679#ent", "<e2>", "and", "the", "presence", "of", "the", "corresponding", "proteins", "in", "haemopoietic", "tissues", "human", "embryogenesis", "."], "h": {"id": "C1704888", "name": "C1704888#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["C0009010#ent", "<e1>", ",", "desipramine", ",", "and", "C0070122#ent", "<e2>", "at", "a", "dose", "of", "5", "mg/kg", "induced", "a", "significant", "decrease", "in", "the", "second", "phase", "."], "h": {"id": "C0009010", "name": "C0009010#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0070122", "name": "C0070122#ent", "pos": [6, 7]}}
{"token": ["Male", "Sprague-Dawley", "rats", "grouped", "based", "on", "agent", "administered", ":", "serotonin", ",", "C0009010#ent", "<e1>", ",", "fluoxetine", ",", "sertraline", ",", "C0070122#ent", "<e2>", ",", "prazosin", ",", "terazosin", ",", "and", "tamsulosin", "."], "h": {"id": "C0009010", "name": "C0009010#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0070122", "name": "C0070122#ent", "pos": [18, 19]}}
{"token": ["(", "1", ")", "Four", "drugs", "are", "approved", "in", "France", "for", "patients", "with", "obsessive-compulsive", "disorders", "namely", "C0009010#ent", "<e1>", "and", "three", "selective", "serotonin", "reuptake", "inhibitors", "SSRIs", ")", ":", "fluoxetine", ",", "C0070122#ent", "<e2>", "and", "sertraline", "."], "h": {"id": "C0009010", "name": "C0009010#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0070122", "name": "C0070122#ent", "pos": [28, 29]}}
{"token": ["One", "hundred", "fifty-nine", "patients", "with", "DSM-IV", "OCD", "underwent", "a", "12-week", "standardized", "treatment", "fluvoxamine", ",", "C0009010#ent", "<e1>", ",", "citalopram", ",", "or", "C0070122#ent", "<e2>", "."], "h": {"id": "C0009010", "name": "C0009010#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0070122", "name": "C0070122#ent", "pos": [20, 21]}}
{"token": ["Multiple", "serum", "chemical", "values", "were", "examined", "in", "92", "patients", "with", "C0017601#ent", "<e1>", "were", "treated", "with", "carbonic", "anhydrase", "inhibitors", "CAIs", ")", "C0000981#ent", "<e2>", "or", "methazolamide", ",", "seeking", "relationships", "between", "serum", "composition", "and", "symptomatic", "side", "effects"], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0000981", "name": "C0000981#ent", "pos": [20, 21]}}
{"token": ["Prevention", "of", "renal", "complications", "the", "time", "of", "C0017601#ent", "<e1>", "treatment", "with", "C0000981#ent", "<e2>", "."], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0000981", "name": "C0000981#ent", "pos": [11, 12]}}
{"token": ["In", "cases", "of", "the", "nonspecific", "ulcerative", "colitis", "C0156147#ent", "<e1>", "colon", "the", "C0010308#ent", "<e2>", "in", "variant", "of", "the", "thriiodinethyronine", "low", "contents", "syndrome", ",", "causing", "the", "necessity", "of", "the", "substitution", "therapy", "conduction", "in", "postoperative", "period", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010308", "name": "C0010308#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "this", "study", "was", "speciation", "analysis", "calcium", ",", "C1166521#ent", "<e1>", ",", "and", "zinc", "in", "C1413682#ent", "<e2>", "fractions", "from", "the", "soluble", "fraction", "of", "a", "toddler", "milk-based", "formula", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [16, 17]}}
{"token": ["Atypical", "pANCA", "occurs", "in", "a", "number", "of", "inflammatory", "conditions", "antigenic", "targets", "include", "C0086376#ent", "<e1>", "other", "than", "myeloperoxidase", "or", "C1335267#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335267", "name": "C1335267#ent", "pos": [18, 19]}}
{"token": ["Iloprost", ",", "an", "analogue", "of", "natural", "prostacyclin", "is", "used", "in", "C0036421#ent", "<e1>", "the", "treatment", "of", "severe", "Raynaud's", "phenomenon", "and", "C0265000#ent", "<e2>"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0265000", "name": "C0265000#ent", "pos": [19, 20]}}
{"token": ["Herpes", "Simplex", "Virus", "HSV-1", ")", "was", "used", "to", "probe", "the", "expression", "of", "enhanced", "reactivation", "(", "C1366644#ent", "<e1>", ")", "in", "cells", "from", "patients", "with", "C0004135#ent", "<e2>", "AT", ")", "."], "h": {"id": "C1366644", "name": "C1366644#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [23, 24]}}
{"token": ["A", "prospective", "study", "serum", "prostatic", "acid", "phosphatase", "C0030350#ent", "<e1>", ")", "levels", "in", "benign", "C0033575#ent", "<e2>", "reported", "."], "h": {"id": "C0030350", "name": "C0030350#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033575", "name": "C0033575#ent", "pos": [13, 14]}}
{"token": ["The", "resulting", "enzyme", "deficiency", "C0268225#ent", "<e1>", "(", "GlcNAc-Asn", ")", "and", "other", "C0268225#ent", "<e1>", "to", "accumulate", "in", "tissues", "and", "body", "fluids", "from", "early", "fetal", "life", "."], "h": {"id": "C0268225", "name": "C0268225#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0268225", "name": "C0268225#ent", "pos": [4, 5]}}
{"token": ["The", "results", "show", "that", "the", "major", "C0268225#ent", "<e1>", "storage", "product", "both", "neural", "and", "extraneural", "tissues", "C0268225#ent", "<e1>", "is", "GlcNAc-Asn", "."], "h": {"id": "C0268225", "name": "C0268225#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0268225", "name": "C0268225#ent", "pos": [6, 7]}}
{"token": ["The", "results", "are", "discussed", "in", "relation", "to", "the", "changes", "in", "retinal", "sorbitol", "fructose", ",", "C0276475#ent", "<e1>", ",", "and", "lactate", "metabolism", "in", "C0011847#ent", "<e2>", "."], "h": {"id": "C0276475", "name": "C0276475#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [21, 22]}}
{"token": ["CsA", ",", "added", "during", "antigen", "activation", "reduced", "the", "number", "of", "C1334114#ent", "<e1>", "cells", ",", "but", "C1332816#ent", "<e2>", "was", "unable", "to", "detect", "variations", "in", "the", "expression", "of", "high", "affinity", "IL-2", "receptors"], "h": {"id": "C1334114", "name": "C1334114#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332816", "name": "C1332816#ent", "pos": [15, 16]}}
{"token": ["In", "this", "report", ",", "by", "utilizing", "a", "novel", "approach", ",", "we", "selected", "cDNAs", "encoding", "the", "C1334114#ent", "<e1>", "variants", "whose", "reactivity", "with", "C1332816#ent", "<e2>", "is", "greatly", "reduced", ",", "while", "retaining", "their", "IL-2", "binding", "activity"], "h": {"id": "C1334114", "name": "C1334114#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332816", "name": "C1332816#ent", "pos": [21, 22]}}
{"token": ["The", "inhibited", "cells", "did", "not", "express", "C1334114#ent", "<e1>", "as", "assayed", "by", "direct", "immunofluorescence", ",", "with", "MoAb", "C1332816#ent", "<e2>", ",", "but", "released", "a", "normal", "amount", "of", "IL", "2", "culture", "medium"], "h": {"id": "C1334114", "name": "C1334114#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332816", "name": "C1332816#ent", "pos": [16, 17]}}
{"token": ["There", "was", "a", "dose-responsive", "increase", "in", "C0027709#ent", "<e1>", "hyperplasia", "and", "inhibition", "of", "the", "aging", "C0022658#ent", "<e2>", "of", "rats", "even", "at", "the", "level", "of", "1", "%", "sodium", "ascorbate"], "h": {"id": "C0027709", "name": "C0027709#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [14, 15]}}
{"token": ["Previous", "data", "suggest", "that", "the", "degree", "of", "failure", "of", "growth", "and", "development", "is", "correlated", "with", "C0022806#ent", "<e1>", "and", "severity", "of", "progressing", "C0024115#ent", "<e2>"], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [21, 22]}}
{"token": ["C0022806#ent", "<e1>", "is", "a", "documented", "problem", "in", "some", "types", "of", "C0024115#ent", "<e2>", "ESLD", ")", "."], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [10, 11]}}
{"token": ["This", "report", "describes", "a", "patient", "with", "a", "long", "history", "C0149521#ent", "<e1>", "course", "was", "complicated", "by", "obstructive", "jaundice", "C0267917#ent", "<e2>", "and", "pancreatic", "insufficiency"], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0267917", "name": "C0267917#ent", "pos": [17, 18]}}
{"token": ["Early", "diagnosis", "treatment", "of", "stricture", "of", "the", "common", "bile", "duct", "C0149521#ent", "<e1>", "essential", "as", "the", "life-threatening", "complications", "of", "biliary", "cirrhosis", "C0267917#ent", "<e2>", "occur", "even", "in", "the", "absence", "of", "clinical", "jaundice"], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0267917", "name": "C0267917#ent", "pos": [20, 21]}}
{"token": ["In", "our", "own", "series", "9", "children", "(", "3", "acute", "biliary", "pancreatitis", "3", "C0149521#ent", "<e1>", "1", "acute", "pancreatitis", "2", "biliary", "duct", "stones", "with", "C0267917#ent", "<e2>", "or", "ampullary", "stenosis", ")", "were", "treated", "successfully", "without", "any", "significant", "complications", "."], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0267917", "name": "C0267917#ent", "pos": [22, 23]}}
{"token": ["An", "imbalance", "of", "C0127082#ent", "<e1>", "tissue", "inhibitor", "metalloproteinases", "were", "also", "observed", "in", "the", "BALF", "of", "C0079556#ent", "<e2>", "CFA", "patients", "."], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079556", "name": "C0079556#ent", "pos": [15, 16]}}
{"token": ["We", "report", "on", "51", "members", "of", "an", "C1366767#ent", "<e1>", "with", "an", "C1504731#ent", "<e2>", "to", "be", "associated", "with", "disorder", "."], "h": {"id": "C1366767", "name": "C1366767#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1504731", "name": "C1504731#ent", "pos": [11, 12]}}
{"token": ["Application", "of", "human", "recombinant", "C1332428#ent", "<e1>", "triggers", "a", "repression", "of", "the", "human", "telomerase", "reverse", "transcriptase", "C1705316#ent", "<e2>", ")", "gene", ",", "shortening", "of", "telomeres", ",", "and", "C1705316#ent", "<e2>", "repression-dependent", "cervical", "cancer", "cell", "death", "."], "h": {"id": "C1332428", "name": "C1332428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [15, 16]}}
{"token": ["Continuous", "treatment", "mouse", "xenograft", "tumors", "with", "C1332428#ent", "<e1>", ",", "or", "silencing", "the", "C1705316#ent", "<e2>", "results", "in", "sustained", "inhibition", "of", "telomerase", "activity", "shortening", "of", "telomeres", ",", "and", "tumor", "growth", "arrest", "."], "h": {"id": "C1332428", "name": "C1332428#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [12, 13]}}
{"token": ["Utilization", "patterns", "were", "similar", "for", "8", "of", "the", "nonsteroidal", "antiinflammatory", "drugs", "with", "differing", "patterns", "seen", "for", "mefenamic", "acid", "C0030078#ent", "<e1>", ",", "phenylbutazone", ",", "and", "C0078840#ent", "<e2>", "."], "h": {"id": "C0030078", "name": "C0030078#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0078840", "name": "C0078840#ent", "pos": [24, 25]}}
{"token": ["Sec24D", "is", "cloned", "by", "screening", "a", "human", "pancreas", "of", "cDNA", "library", "an", "expressed", "sequence", "tag", "C1705156#ent", "<e1>", ")", "fragment", "that", "is", "C1512488#ent", "<e2>", "to", ",", "but", "distinct", "from", ",", "Sec24A", "and", "Sec24B", "."], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [21, 22]}}
{"token": ["This", "C1705156#ent", "<e1>", "is", "also", "highly", "C1512488#ent", "<e2>", "(", "90", "%", ")", "to", "the", "Torpedo", "californica", "87", "kDa", "phosphoprotein", "."], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}}
{"token": ["A", "murine", "C1705156#ent", "<e1>", "clone", "and", "a", "highly", "C1512488#ent", "<e2>", "human", "C1705156#ent", "<e1>", "clone", ",", "containing", "the", "entire", "ORF", ",", "were", "chosen", "for", "sequencing", "."], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [8, 9]}}
{"token": ["Screening", "human", "adult", "brain", "and", "skeletal", "muscle", "cDNA", "libraries", "with", "this", "C1705156#ent", "<e1>", "resulted", "in", "cloning", "multiple", "cDNAs", "which", "encode", "several", "splice", "forms", "C1512488#ent", "<e2>", "to", "the", "C-terminal", "domain", "dystrophin", "."], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [23, 24]}}
{"token": ["The", "occurrence", "of", "features", "of", "C0265341#ent", "<e1>", "Axenfeld's", "anomaly", "association", "with", "posterior", "polymorphous", "dystrophy", "the", "hypothesis", "that", "all", "these", "C0029896#ent", "<e2>", "may", "be", "characterized", "by", "abnormalities", "of", "tissues", "derived", "from", "neural", "crest", "cells"], "h": {"id": "C0265341", "name": "C0265341#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [19, 20]}}
{"token": ["Protein", "phosphatase", "3", "PPP3", ",", "formerly", "C1418845#ent", "<e1>", ",", "Calcineurin", ")", ",", "a", "C0084210#ent", "<e2>", "is", "a", "heterodimer", "composed", "of", "one", "catalytic", "subunit", "PPP3C", ",", "Calcineurin", "A", "and", "one", "regulatory", "subunit", "PPP3R", ",", "Calcineurin", "B", "."], "h": {"id": "C1418845", "name": "C1418845#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0084210", "name": "C0084210#ent", "pos": [13, 14]}}
{"token": ["Important", "and", "obligatory", "roles", "for", "C1418845#ent", "<e1>", ",", "PP2C", ",", "and", "newly", "discovered", "C0084210#ent", "<e2>", "also", "likely", "."], "h": {"id": "C1418845", "name": "C1418845#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0084210", "name": "C0084210#ent", "pos": [13, 14]}}
{"token": ["C1418845#ent", "<e1>", "is", "one", "of", "the", "major", "C0084210#ent", "<e2>", "the", "brain", "."], "h": {"id": "C1418845", "name": "C1418845#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0084210", "name": "C0084210#ent", "pos": [7, 8]}}
{"token": ["The", "SUMO", "residues", "could", "be", "efficiently", "removed", "by", "incubating", "SUMOylated", "IE1", "with", "C1425182#ent", "<e1>", ",", "a", "recently", "identified", "C0030940#ent", "<e2>"], "h": {"id": "C1425182", "name": "C1425182#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [18, 19]}}
{"token": ["A", "24-year-old", "male", "presented", "with", "a", "4", "year", "history", "of", "a", "crusted", "erythematous", "papular", "eruption", "of", "the", "C0240940#ent", "<e1>", "and", "external", "auditory", "meati", "a", "12", "month", "history", "of", "C0030193#ent", "<e2>", "perianal", "ulceration"], "h": {"id": "C0240940", "name": "C0240940#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [28, 29]}}
{"token": ["The", "binding", "of", "C0056650#ent", "<e1>", "to", "reconstituted", "C0031179#ent", "<e2>", ",", "proto", ",", "meso", "and", "deutero", ",", "was", "investigated", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031179", "name": "C0031179#ent", "pos": [7, 8]}}
{"token": ["C0056650#ent", "<e1>", "does", "not", "appear", "to", "inhibit", "the", "C0031179#ent", "<e2>", "activity", "in", "erythrocytes", "but", "has", "little", "effect", "on", "catalase", "in", "these", "cells", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031179", "name": "C0031179#ent", "pos": [8, 9]}}
{"token": ["The", "enzymatic", "conversion", "C0056650#ent", "<e1>", "to", "cyanyl", "radical", "by", "C0031179#ent", "<e2>", "should", "be", "considered", "in", "addition", "to", "its", "well-known", "role", "as", "a", "metal", "ligand", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031179", "name": "C0031179#ent", "pos": [9, 10]}}
{"token": ["In", "both", "cases", ",", "the", "(15)N", "chemical", "shift", "of", "bound", "C0056650#ent", "<e1>", "was", "reminiscent", "of", "that", "in", "C0031179#ent", "<e2>", "and", "the", "orientation", "of", "the", "proximal", "histidine", "as", "in", "other", "truncated", "Hbs", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031179", "name": "C0031179#ent", "pos": [17, 18]}}
{"token": ["Anti-GBM", "nephritis", "a", "rapidly", "progressive", ",", "isolated", "C0017658#ent", "<e1>", "in", "association", "with", "circulating", "C1332309#ent", "<e2>"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C1332309", "name": "C1332309#ent", "pos": [13, 14]}}
{"token": ["Both", "leukemic", "and", "solid", "tumor", "cells", "up", "this", "alkyl-lysophospholipid", "and", "expressed", "the", "two", "putative", "edelfosine", "targets", ",", "namely", "C1539477#ent", "<e1>", "also", "known", "as", "APO-1", "or", "C1539477#ent", "<e1>", ")", "and", "endoplasmic", "reticulum", "CTP", "phosphocholine", "cytidylyltransferase"], "h": {"id": "C1539477", "name": "C1539477#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [18, 19]}}
{"token": ["C1336626#ent", "<e1>", "(", "10", "mg/kg", "per", "day", ")", "plus", "C0594375#ent", "<e2>", "(", "125", "mg/kg", ")", ",", "or", "C1336626#ent", "<e1>", "(", "20", "mg/kg", "per", "day", ")", "plus", "C0594375#ent", "<e2>", "(", "150", "mg/kg", ")", "."], "h": {"id": "C1336626", "name": "C1336626#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [9, 10]}}
{"token": ["The", "reduction", "in", "Thy-1", "mRNA", "levels", "by", "C0022614#ent", "<e1>", "was", "also", "significantly", "attenuated", "by", "concomitant", "injection", "of", "C0062068#ent", "<e2>", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0062068", "name": "C0062068#ent", "pos": [17, 18]}}
{"token": ["The", "other", ",", "a", "16-month-old", "girl", ",", "showed", "C0031111#ent", "<e1>", "the", "bones", "and", "parathyroid", "hyperplasia", "secondary", "type", "suggesting", "that", "the", "C1956257#ent", "<e2>", "from", "hypercalcemia", "caused", "by", "a", "parathormone", "or", "prostaglandin-secreting", "tumor"], "h": {"id": "C0031111", "name": "C0031111#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1956257", "name": "C1956257#ent", "pos": [20, 21]}}
{"token": ["C0700541#ent", "<e1>", "frequently", "administered", "to", "C1334982#ent", "<e2>", "primates", "as", "a", "means", "of", "chemical", "restraint"], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334982", "name": "C1334982#ent", "pos": [5, 6]}}
{"token": ["Medetomidine", ",", "an", "alpha(2)-adrenergic", "receptor", "administered", "with", "C0700541#ent", "<e1>", ",", "induces", "sedation/anesthesia", "in", "C1334982#ent", "<e2>", "a", "dose-dependent", ",", "species-specific", "manner", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334982", "name": "C1334982#ent", "pos": [13, 14]}}
{"token": ["In", "addition", "to", "receptors", ",", "monoamine", "uptake", "mechanisms", ",", "such", "as", "the", "serotonin", "transporter", "C3814032#ent", "<e1>", ")", ",", "are", "candidate", "C1417679#ent", "<e2>", "for", "personality", "traits"], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["The", "different", "5-HT", "(", "serotonin", ")", "receptors", "including", "the", "serotonin", "transporter", "C3814032#ent", "<e1>", ")", "are", "candidate", "C1417679#ent", "<e2>", "for", "affective", "disorders", "as", "major", "depressive", "disorder", "MDD", ")", "and", "bipolar", "disorder", "BD", ")", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "we", "investigated", "the", "effect", "of", "C0074554#ent", "<e1>", "on", "phospholipase", "C", "PLC", ")", "and", "C0033634#ent", "<e2>", "PKC", ")", "activation", "stimulated", "by", "PDGF", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "whether", "local", "overexpression", "of", "interleukin-12", "(", "IL-12", ")", ",", "a", "pleiotropic", "cytokine", "promotes", "the", "development", "of", "naive", "T", "cells", "Th1", "cells", "could", "aggravate", "murine", "streptococcal", "cell", "wall", "C0003864#ent", "<e1>", ",", "a", "model", "of", "C0263678#ent", "<e2>"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0263678", "name": "C0263678#ent", "pos": [35, 36]}}
{"token": ["This", "C1332924#ent", "<e1>", "was", "identified", "using", "a", "coimmunoprecipitation", "strategy", "employing", "C3539602#ent", "<e2>", "as", "bait", "."], "h": {"id": "C1332924", "name": "C1332924#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539602", "name": "C3539602#ent", "pos": [10, 11]}}
{"token": ["Hydrocarbon", "generation", "C3539947#ent", "<e1>", "inhibited", "by", "hydroxyl", "radical", ",", "but", "catalase", "and", "C0669516#ent", "<e2>", "more", "efficient", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [12, 13]}}
{"token": ["This", "gene", "(", "Cl-SOD1", ")", "consists", "of", "471", "bp", "encoding", "157", "C3539947#ent", "<e1>", "the", "associated", "protein", "59.9", "-", "76.7", "%", "identity", "with", "Cu/Zn", "C0669516#ent", "<e2>", "other", "yeast", "species"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [23, 24]}}
{"token": ["The", "predicted", "C3539947#ent", "<e1>", "these", "enzymes", "are", "C0669516#ent", "<e2>", "SODs", ")", ",", "glutathione-S-transferase", "(", "GST", ")", ",", "glutathione", "peroxidase", "GPX", ")", ",", "and", "catalases", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [7, 8]}}
{"token": ["There", "have", "been", "conflicting", "reports", "on", ",", "and", "no", "plausible", "biologic", "explanation", "for", ",", "a", "protective", "effect", "oral", "contraceptive", "C1412791#ent", "<e1>", ")", "use", "on", "the", "development", "of", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [29, 30]}}
{"token": ["Circulating", "immune", "complexes", "complement", "components", "C1q", ",", "C3", "and", "C4", "were", "measured", "following", "polyethylene", "glycol", "precipitation", "serum", "from", "patients", "with", "ovarian", "cancer", "C1412791#ent", "<e1>", ")", ",", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "and", "control", "patients", "CP", ")", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [28, 29]}}
{"token": ["We", "therefore", "conclude", "that", "C1412791#ent", "<e1>", "use", "prior", "to", "the", "onset", "of", "C0003873#ent", "<e2>", "symptoms", "is", "only", "associated", "with", "reduction", "in", "the", "incidence", "of", "severe", "C0003873#ent", "<e2>", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}}
{"token": ["Meta-analyses", ",", "based", "mainly", "on", "fluoxetine", "comparator", "data", ",", "suggest", "that", "the", "C3537046#ent", "<e1>", "venlafaxine", "has", "superior", "efficacy", "to", "C0360105#ent", "<e2>", "in", "treatment", "of", "major", "depression", "."], "h": {"id": "C3537046", "name": "C3537046#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0360105", "name": "C0360105#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "NR2B", "subunit-containing", "C0022614#ent", "<e1>", "contribute", "significantly", "to", "the", "enhanced", "spatiotemporal", "spread", "of", "C0235480#ent", "<e2>", "in", "vitro", "the", "rat", "freeze-lesion", "model", "of", "focal", "cortical", "dysplasia"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [16, 17]}}
{"token": ["We", "have", "also", "determined", ",", "in", "two", "in", "vitro", "models", "of", "P450", "TB", ",", "the", "affinity", "for", "this", "isozyme", "of", "C0003211#ent", "<e1>", "from", "other", "chemical", "classes", "acetylsalicylic", "acid", "C0025152#ent", "<e2>", "indomethacin", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [20, 21]}, "relation": "structural_class_of", "t": {"id": "C0025152", "name": "C0025152#ent", "pos": [28, 29]}}
{"token": ["The", "effects", "of", "C0003211#ent", "<e1>", "the", "fenamate", "group", "(", "C0025152#ent", "<e2>", "and", "tolfenamic", "acids", ")", "on", "spontaneous", "miniature", "inhibitory", "postsynaptic", "currents", "Purkinje's", "cells", "studied", "in", "mouse", "cerebellar", "slices", "by", "the", "whole", "cell", "patch-clamp", "method", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C0025152", "name": "C0025152#ent", "pos": [9, 10]}}
{"token": ["The", "binding", "activities", "of", "transcription", "factors", "C0003993#ent", "<e1>", ",", "NF-1", "and", "CBP", "are", "unaffected", "by", "DTT", "or", "C0061516#ent", "<e2>"], "h": {"id": "C0003993", "name": "C0003993#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0061516", "name": "C0061516#ent", "pos": [17, 18]}}
{"token": ["Sotos", "syndrome", "or", "C0175695#ent", "<e1>", "is", "a", "rare", "C0019247#ent", "<e2>", "by", "tall", "stature", "gigantism", ",", "dolichocephaly", ",", "advanced", "bone", "age", "and", "learning", "disability"], "h": {"id": "C0175695", "name": "C0175695#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [8, 9]}}
{"token": ["Six", "patients", "who", "had", "undergone", "bilateral", "adrenalectomy", "C0271725#ent", "<e1>", "who", "had", "Nelson's", "syndrome", "given", "C0022616#ent", "<e2>", "40", "mg", "twice", "daily", "and", "placebo", ",", "for", "at", "least", "two", "months", "each", ",", "in", "a", "double", "blind", "crossover", "study"], "h": {"id": "C0271725", "name": "C0271725#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [14, 15]}}
{"token": ["The", "concentrations", "of", "C0022265#ent", "<e1>", "for", "inducing", "C3272781#ent", "<e2>", "similar", "to", "those", "required", "for", "inducing", "liver", "transglutaminase"], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3272781", "name": "C3272781#ent", "pos": [7, 8]}}
{"token": ["Primary", "peripheral", "blood", "lymphocytes", "monocytes", "were", "cotransfected", "with", "either", "the", "HIV-1BaL", "or", "HIV-1-IIIB", "LTR", "fused", "to", "the", "C1413138#ent", "<e1>", "their", "respective", "C0017337#ent", "<e2>"], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [21, 22]}}
{"token": ["In", "those", "cell", "lines", "expressing", "low", "levels", "of", "cdc2", "and", "C1332733#ent", "<e1>", "an", "appreciable", "increase", "in", "expression", "was", "seen", "soon", "after", "C1970209#ent", "<e2>", "E1A", "could", "be", "detected", "."], "h": {"id": "C1332733", "name": "C1332733#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1970209", "name": "C1970209#ent", "pos": [21, 22]}}
{"token": ["Mutations", "in", "the", "C0079429#ent", "<e1>", "encoding", "phospholipase", "A(2)", "group", "VI", "PLA2G6", ")", "are", "associated", "with", "childhood", "neurologic", "disorders", "C0270724#ent", "<e2>", "INAD", ")", "and", "idiopathic", "neurodegeneration", "brain", "iron", "accumulation", "NBIA", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0270724", "name": "C0270724#ent", "pos": [18, 19]}}
{"token": ["Hence", "the", "aim", "of", "this", "study", "was", "to", "investigate", "the", "factor", "structure", "the", "SLQ-38", "in", "a", "sample", "of", "560", "individuals", "with", "C1417325#ent", "<e1>", "MS", ")", ",", "cancer", ",", "cardiac", ",", "and", "C0022658#ent", "<e2>"], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [31, 32]}}
{"token": ["Eight", "patients", "with", "transient", "C0007787#ent", "<e1>", "and", "three", "with", "partial", "nonprogressive", "strokes", "associated", "with", "C0026267#ent", "<e2>", "are", "reported", "."], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026267", "name": "C0026267#ent", "pos": [14, 15]}}
{"token": ["Further", "studies", "using", "testicular", "cDNA", "and", "C3273638#ent", "<e1>", "probes", "defined", "2", "new", "members", "of", "this", "gene", "family", "C1420437#ent", "<e2>", "and", "SSX5", ",", "while", "a", "shorter", "cDNA", "variant", "of", "C1420437#ent", "<e2>", "was", "also", "identified", "."], "h": {"id": "C3273638", "name": "C3273638#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420437", "name": "C1420437#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "similar", "to", "C0009014#ent", "<e1>", ",", "a", "high", "dosage", "of", "tizanidine", "influences", "gastric", "acid", "secretion", "and", "C0038358#ent", "<e2>", "although", "the", "activity", "is", "lower", "than", "that", "of", "C0009014#ent", "<e1>", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [6, 7]}}
{"token": ["The", "bHLH", "domain", "C0796355#ent", "<e1>", "is", "especially", "homologous", "to", "those", "encoded", "by", "C1336574#ent", "<e2>", "and", "LYL1", ",", "distinct", "genes", "that", "were", "also", "identified", "on", "the", "basis", "of", "chromosomal", "rearrangement", "T-ALL", "."], "h": {"id": "C0796355", "name": "C0796355#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336574", "name": "C1336574#ent", "pos": [12, 13]}}
{"token": ["Two", "C1705286#ent", "<e1>", "binding", "sites", "in", "the", "C0380093#ent", "<e2>", "5", "'", "regulatory", "region", "as", "cis", "regulatory", "elements", "as", "direct", "targets", "of", "R2R3", "MYB", "transcription", "factors", "such", "as", "WEREWOLF", ",", "GLABRA1", ",", "and", "TRANSPARENT", "TESTA2", "."], "h": {"id": "C1705286", "name": "C1705286#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0380093", "name": "C0380093#ent", "pos": [7, 8]}}
{"token": ["The", "rate", "of", "glucose", "incorporation", "into", "C0017860#ent", "<e1>", "and", "the", "activities", "of", "C1415199#ent", "<e2>", "malic", "enzyme", "not", "significantly", "affected", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415199", "name": "C1415199#ent", "pos": [12, 13]}}
{"token": ["A", "70-year-old", "woman", "had", "erythema", ",", "oedema", "and", "vesicles", "on", "sun-exposed", "areas", "after", "5", "days", "of", "C0064113#ent", "<e1>", "treatment", "for", "C0006849#ent", "<e2>"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [20, 21]}}
{"token": ["C0064113#ent", "<e1>", "was", "superior", "to", "fluconazole", "in", "C0006849#ent", "<e2>", ",", "cryptococcosis", ",", "sporotrichosis", "and", "aspergillosis", ",", "to", "amphotericin", "B", "to", "flucytosine", "in", "C0006849#ent", "<e2>", ",", "cryptococcosis", "and", "aspergillosis", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [7, 8]}}
{"token": ["C1417005#ent", "<e1>", "expression", "was", "compared", "with", "Ki-67", "staining", "expression", "of", "C1413038#ent", "<e2>", "CA", ")", "IX", ",", "a", "hypoxic", "marker", "."], "h": {"id": "C1417005", "name": "C1417005#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413038", "name": "C1413038#ent", "pos": [10, 11]}}
{"token": ["Any", "C0033575#ent", "<e1>", "comedication", "affecting", "C3714798#ent", "<e2>", "activity", "should", "be", "taken", "into", "account", "when", "prescribing", "corticosteroids", "."], "h": {"id": "C0033575", "name": "C0033575#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [5, 6]}}
{"token": ["Previously", ",", "we", "have", "demonstrated", "that", "the", "human", "cytomegalovirus-encoded", "chemokine", "receptor", "US28", "mediates", "human", "vascular", "smooth", "muscle", "cell", "C1539322#ent", "<e1>", ")", "migration", "in", "response", "to", "either", "C1332691#ent", "<e2>", "or", "monocyte", "chemoattractant", "protein", "1"], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [26, 27]}}
{"token": ["The", "amino", "acid", "phosphorylated", "in", "vitro", "exclusively", "tyrosine", "in", "both", "cases", ",", "whereas", "C4284127#ent", "<e1>", "phosphorylated", "in", "vivo", "phosphoserine", "as", "a", "major", "C0524823#ent", "<e2>", "traces", "of", "phosphotyrosine", "and", "phosphothreoine", "."], "h": {"id": "C4284127", "name": "C4284127#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524823", "name": "C0524823#ent", "pos": [22, 23]}}
{"token": ["Subnanomolar", "affinity", "for", "human", "5HT2A", "receptors", "was", "observed", "for", "C0083880#ent", "<e1>", ",", "sertindole", ",", "risperidone", ",", "C0753678#ent", "<e2>", "and", "ziprasidone", "."], "h": {"id": "C0083880", "name": "C0083880#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0753678", "name": "C0753678#ent", "pos": [16, 17]}}
{"token": ["FIP1L1-PDGFRalpha", "causes", "hypereosinophilic", "syndrome", "C0020352#ent", "<e1>", ")", "and", "is", "inhibited", "by", "the", "tyrosine", "kinase", "inhibitor", "imatinib", "C0935987#ent", "<e2>", ")", "."], "h": {"id": "C0020352", "name": "C0020352#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0935987", "name": "C0935987#ent", "pos": [16, 17]}}
{"token": ["C4084905#ent", "<e1>", "is", "a", "protein", "kinase", "of", "the", "C0751984#ent", "<e2>", "Rac", "and", "Cdc42", "that", "previous", "work", "has", "implicated", "in", "endothelial", "cell", "migration", "modulation", "of", "cell", "contraction"], "h": {"id": "C4084905", "name": "C4084905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [8, 9]}}
{"token": ["p21-activated", "kinase", "1", "C4084905#ent", "<e1>", ")", "is", "a", "mediator", "of", "downstream", "signaling", "the", "C0751984#ent", "<e2>", "Rac", "and", "Cdc42", "."], "h": {"id": "C4084905", "name": "C4084905#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [13, 14]}}
{"token": ["The", "clinical", "presentation", "tuberculous", "enteritis", "C0156147#ent", "<e1>", "similar", ",", "though", "tuberculosis", "is", "strongly", "suggested", "by", "associated", "C0024115#ent", "<e2>", "radiological", "evidence", "of", "caecal", "involvement", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [16, 17]}}
{"token": ["Eight", "of", "10", "subjects", "suffering", "from", "C0002066#ent", "<e1>", ",", "with", "or", "without", "ochronotic", "arthropathy", "C0263854#ent", "<e2>", ",", "had", "B27", "."], "h": {"id": "C0002066", "name": "C0002066#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0263854", "name": "C0263854#ent", "pos": [14, 15]}}
{"token": ["Rather", ",", "RACK1", "selectively", "inhibits", "G", "betagamma-stimulated", "phosphatidylinositol", "3-kinase", "gamma", "C1705590#ent", "<e1>", "and", "C0031671#ent", "<e2>", "PLC", ")", "beta", "activity", "due", "to", "the", "competitive", "binding", "RACK1", ",", "C1705590#ent", "<e1>", "and", "PLC", "beta", "to", "G", "betagamma"], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [10, 11]}}
{"token": ["Barbiturate", "synergism", "in", "mice", "is", "lower", "with", "C0054151#ent", "<e1>", "than", "with", "C0012010#ent", "<e2>", ",", "while", "alcohol-induced", "coma", "prolonged", "over", "the", "same", "dose", "range", "."], "h": {"id": "C0054151", "name": "C0054151#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [11, 12]}}
{"token": ["The", "anticonflict", "effect", "C0054151#ent", "<e1>", "in", "rats", "was", "approximately", "as", "potent", "as", "that", "of", "C0012010#ent", "<e2>", "and", "was", "augmented", "following", "chronic", "administration", "10", "days", "."], "h": {"id": "C0054151", "name": "C0054151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [14, 15]}}
{"token": ["During", "chronic", "administration", "C0054151#ent", "<e1>", ",", "triazolam", "and", "C0012010#ent", "<e2>", "all", "animals", "gained", "body", "weight"], "h": {"id": "C0054151", "name": "C0054151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [8, 9]}}
{"token": ["C0054151#ent", "<e1>", "and", "triazolam", "had", "a", "shorter", "duration", "of", "action", "than", "C0012010#ent", "<e2>", "and", "nitrazepam", "."], "h": {"id": "C0054151", "name": "C0054151#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [11, 12]}}
{"token": ["The", "C0752229#ent", "<e1>", "182,780", "prevented", "both", "growth", "and", "C1332733#ent", "<e2>", "activation", "induced", "by", "estradiol", "or", "DDT", "."], "h": {"id": "C0752229", "name": "C0752229#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332733", "name": "C1332733#ent", "pos": [8, 9]}}
{"token": ["The", "term", "\"", "renal", "osteodystrophy", "is", "used", "to", "include", "C0026857#ent", "<e1>", "patients", "with", "chronic", "renal", "failure", "osteitis", "fibrosa", "C0029442#ent", "<e2>", ",", "osteosclerosis", ",", "osteoporosis", "and", "the", "frequently", "associated", "extraskeletal", "calcifications", "."], "h": {"id": "C0026857", "name": "C0026857#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0029442", "name": "C0029442#ent", "pos": [18, 19]}}
{"token": ["The", "C0015230#ent", "<e1>", "typically", "is", "a", "blanchable", ",", "C0221201#ent", "<e2>"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0221201", "name": "C0221201#ent", "pos": [8, 9]}}
{"token": ["Treatment", "with", "C0012789#ent", "<e1>", ",", "which", "inactivates", "secretory", "C2756983#ent", "<e2>", ",", "decreased", "the", "amount", "of", "AA", "released", "by", "TNFalpha/zVAD", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2756983", "name": "C2756983#ent", "pos": [8, 9]}}
{"token": ["We", "also", "show", "that", "Ctk2", "and", "C1384557#ent", "<e1>", "can", "each", "interact", "independently", "with", "the", "C0031727#ent", "<e2>", "."], "h": {"id": "C1384557", "name": "C1384557#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}}
{"token": ["C0543459#ent", "<e1>", "is", "mainly", "catalyzed", "by", "CYP2D6", "and", "partially", "catalyzed", "by", "C1620185#ent", "<e2>", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [11, 12]}}
{"token": ["C0543459#ent", "<e1>", "is", "metabolized", "by", "CYP2D6", "and", "C1620185#ent", "<e2>", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [7, 8]}}
{"token": ["Side", "effects", "fever", ",", "pain", ",", "increased", "serum", "amylase", "C0004002#ent", "<e1>", "and", "one", "C0023885#ent", "<e2>", "death", "of", "liver", "failure"], "h": {"id": "C0004002", "name": "C0004002#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023885", "name": "C0023885#ent", "pos": [13, 14]}}
{"token": ["We", "examined", "whether", "LC", "neuronal", "activity", "C1706383#ent", "<e1>", "expression", ",", "and", "C0001044#ent", "<e2>", "staining", "are", "altered", "after", "peripheral", "(", "systemic", ")", "or", "direct", "intracoerulear", "injection", "of", "soman", "in", "anesthetized", "rats", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001044", "name": "C0001044#ent", "pos": [11, 12]}}
{"token": ["By", "analyzing", "these", "mutants", "in", "minicells", "the", "genes", "of", "the", "six", "C1305923#ent", "<e1>", "could", "be", "located", "on", "the", "physical", "map", "C2698717#ent", "<e2>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2698717", "name": "C2698717#ent", "pos": [20, 21]}}
{"token": ["Both", "CAR", "and", "C4283882#ent", "<e1>", "transcriptionally", "up-regulate", "the", "C1828473#ent", "<e2>", "these", "elements", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1828473", "name": "C1828473#ent", "pos": [8, 9]}}
{"token": ["Each", "contained", "a", "dicistronic", "transcription", "unit", "comprising", "the", "coding", "sequence", "C3853636#ent", "<e1>", "DHFR", ")", "followed", "by", "the", "C0079429#ent", "<e2>", "for", "xanthine-guanine", "phosphoribosyl", "transferase", "XGPRT", ")", "from", "Escherichia", "coli"], "h": {"id": "C3853636", "name": "C3853636#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}}
{"token": ["Each", "contained", "a", "dicistronic", "transcription", "unit", "comprising", "the", "coding", "sequence", "mouse", "dihydrofolate", "reductase", "C3853636#ent", "<e1>", ")", "followed", "by", "the", "C0079429#ent", "<e2>", "for", "xanthine-guanine", "phosphoribosyl", "transferase", "XGPRT", ")", "from", "Escherichia", "coli"], "h": {"id": "C3853636", "name": "C3853636#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "the", "mechanism", "of", "this", "process", ",", "we", "examined", "the", "expression", "of", "cyclins", "D1", "C1415944#ent", "<e1>", ",", "and", "D3", "and", "the", "activity", "of", "their", "associated", "C0031727#ent", "<e2>", "."], "h": {"id": "C1415944", "name": "C1415944#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [26, 27]}}
{"token": ["Tyrosinemia", "type", "II", "an", "C3899988#ent", "<e1>", "due", "to", "an", "enzymatic", "deficit", "in", "C1420590#ent", "<e2>"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420590", "name": "C1420590#ent", "pos": [12, 13]}}
{"token": ["Kinetic", "analysis", "other", "biochemical", "analyses", "that", "C1413153#ent", "<e1>", "retards", "the", "enzymatic", "reaction", "for", "the", "C0030956#ent", "<e2>"], "h": {"id": "C1413153", "name": "C1413153#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}}
{"token": ["These", "studies", "revealed", "that", "phage-displaying", "Hsp47", "binding", "C0030956#ent", "<e1>", "bound", "to", "cell", "lines", "expressing", "C1413153#ent", "<e2>", "and", "that", "the", "C0030956#ent", "<e1>", "were", "rapidly", "taken", "up", "to", "a", "location", "coincident", "with", "Hsp47", "staining", "."], "h": {"id": "C1413153", "name": "C1413153#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}}
{"token": ["Since", "C1413153#ent", "<e1>", "possesses", "a", "highly", "restricted", "binding", "cleft", "C0030956#ent", "<e2>", "libraries", "were", "used", "to", "characterize", "peptides", "binding", "to", "C1413153#ent", "<e1>", "and", "then", "to", "target", "this", "protein", "on", "carcinoma", "cell", "lines", "in", "vitro"], "h": {"id": "C1413153", "name": "C1413153#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}}
{"token": ["The", "abundant", "surface", "glycolipid", "lipophosphoglycan", "(", "C2673196#ent", "<e1>", ")", ",", "of", "Leishmania", "promastigotes", "composed", "of", "C0017759#ent", "<e2>", "repeating", "units", "linked", "via", "a", "C0017759#ent", "<e2>", "core", "to", "a", "conserved", "lyso", "alkylphosphatidylinositol", "membrane", "anchor"], "h": {"id": "C2673196", "name": "C2673196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017759", "name": "C0017759#ent", "pos": [15, 16]}}
{"token": ["Fragmentation", "of", "C2673196#ent", "<e1>", "revealed", "that", "the", "inhibitory", "activity", "C2673196#ent", "<e1>", "required", "both", "the", "repeating", "phosphorylated", "disaccharides", "the", "C0017759#ent", "<e1>", "core", "."], "h": {"id": "C2673196", "name": "C2673196#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017759", "name": "C0017759#ent", "pos": [18, 19]}}
{"token": ["Levsin", "is", "an", "anticholinergic", "drug", "in", "the", "treatment", "of", "irritable", "bowel", "syndromes", "functional", "C0017178#ent", "<e1>", "and", "as", "adjunct", "therapy", "in", "C0030920#ent", "<e2>"], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [20, 21]}}
{"token": ["Engineered", "mutations", "the", "second", "C1420342#ent", "<e1>", "not", "yield", "a", "C0669365#ent", "<e2>", "active", "Mac1", "."], "h": {"id": "C1420342", "name": "C1420342#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [9, 10]}}
{"token": ["Sparc-null", "spleens", "lacked", "normal", "C1420342#ent", "<e1>", "expression", "in", "red", "and", "white", "pulp", "marginal", "zones", "C0669365#ent", "<e2>", "and", "sinusoidal", "cells"], "h": {"id": "C1420342", "name": "C1420342#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}}
{"token": ["Although", "C0002962#ent", "<e1>", "the", "most", "common", "symptom", "of", "C1956346#ent", "<e2>", "some", "patients", "do", "not", "experience", "angina", "during", "ischemic", "episodes"], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [8, 9]}}
{"token": ["Research", "aimed", "at", "evaluating", "C0002962#ent", "<e1>", "AP", ")", "symptoms", "in", "patients", "with", "C1956346#ent", "<e2>", "CHD", ")", "requires", "a", "comprehensive", "assessment", "tool", "to", "this", "population", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [12, 13]}}
{"token": ["C0002962#ent", "<e1>", "the", "absence", "of", "significant", "C1956346#ent", "<e2>", "another", "presentation", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [6, 7]}}
{"token": ["The", "limited", "C4284744#ent", "<e1>", "repertoire", "of", "swine", "contrasts", "sharply", "with", "the", "porcine", "C0524891#ent", "<e2>", "repertoire", ",", "which", "is", "extensive", ",", "extraordinarily", "conserved", "and", "nearly", "identical", "to", "that", "in", "humans", "."], "h": {"id": "C4284744", "name": "C4284744#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0524891", "name": "C0524891#ent", "pos": [12, 13]}}
{"token": ["In", "the", "present", "study", ",", "we", "simultaneously", "test", "linkage", "association", "of", "the", "C1332773#ent", "<e1>", "COL1A2", ")", "gene", "with", "bone", "mineral", "density", "C1414083#ent", "<e2>", ")", "and", "bone", "area"], "h": {"id": "C1332773", "name": "C1332773#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "TGF-beta1", "resulted", "in", "ubiquitination", "of", "C2983365#ent", "<e1>", "suggesting", "that", "TGF-beta1", "facilitates", "ubiquitination", "and", "proteasomal", "degradation", "C1417530#ent", "<e2>", "and", "thereby", "attenuates", "MyD88-dependent", "signaling", "by", "decreasing", "cellular", "levels", "C2983365#ent", "<e1>"], "h": {"id": "C1417530", "name": "C1417530#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2983365", "name": "C2983365#ent", "pos": [7, 8]}}
{"token": ["Relaxations", "to", "both", "carbachol", "and", "sodium", "nitroprusside", "attenuated", "in", "the", "presence", "of", "raised", "extracellular", "potassium", "the", "C0872245#ent", "<e1>", "iberiotoxin", "and", "C0076252#ent", "<e2>", "."], "h": {"id": "C0872245", "name": "C0872245#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0076252", "name": "C0076252#ent", "pos": [20, 21]}}
{"token": ["The", "C0872245#ent", "<e1>", "0.1", "-", "5", "mM", ")", "and", "C0076252#ent", "<e2>", "5", "-", "50", "mM", ")", "had", "no", "inhibitory", "effect", "on", "fusion", "."], "h": {"id": "C0872245", "name": "C0872245#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0076252", "name": "C0076252#ent", "pos": [9, 10]}}
{"token": ["The", "reaction", ",", "documented", "by", "rechallenge", "during", "hospitalization", ",", "was", "characterized", "by", "marked", "hypotension", ",", "fever", ",", "rigors", ",", "C0009763#ent", "<e1>", ",", "meningitis", ",", "nausea", ",", "C0019559#ent", "<e2>", ",", "and", "leukopenia", "."], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0019559", "name": "C0019559#ent", "pos": [26, 27]}}
{"token": ["The", "C0001156#ent", "<e1>", "relatively", "insensitive", "to", "phosphoenolpyruvate", "(", "C1335057#ent", "<e2>", ")", "."], "h": {"id": "C0001156", "name": "C0001156#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335057", "name": "C1335057#ent", "pos": [8, 9]}}
{"token": ["The", "protein", "levels", "C0667830#ent", "<e1>", "and", "pro-caspase-3", "were", "not", "affected", "by", "ADR", ",", "whereas", "C0758917#ent", "<e2>", "and", "Apaf-1", "were", "up-regulated", "."], "h": {"id": "C0667830", "name": "C0667830#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0758917", "name": "C0758917#ent", "pos": [14, 15]}}
{"token": ["Several", "biological", "activities", "N-acetylmuramyl-L-alanyl-D-isoglutamine", "(", "C1414134#ent", "<e1>", "for", "muramyl", "dipeptide", ",", "a", "synthetic", "immunoadjuvant", "are", "inhibited", "after", "C0007158#ent", "<e2>", "with", "p-aminophenol", "."], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007158", "name": "C0007158#ent", "pos": [17, 18]}}
{"token": ["Current", "gene", "therapy", "1", "safety", "trials", "for", "PD", "include", "the", "delivery", "of", "a", "growth", "factor", "C1334906#ent", "<e1>", "via", "the", "glial", "cell", "line-derived", "neurotrophic", "factor", "receptor", "and", "a", "transmitter", "enzyme", "glutamic", "acid", "decarboxylase", "C1413943#ent", "<e2>", "."], "h": {"id": "C1334906", "name": "C1334906#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1413943", "name": "C1413943#ent", "pos": [32, 33]}}
{"token": ["To", "improve", "the", "C0518214#ent", "<e1>", "in", "UC", "patients", ",", "all", "administrated", "C1367452#ent", "<e2>", "must", "be", "tapered", "off", "after", "achieving", "the", "remission", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [11, 12]}}
{"token": ["The", "main", "reason", "for", "C0017373#ent", "<e1>", "jobs", "was", "claimed", "to", "be", "C0011119#ent", "<e2>", "and", "it", "was", "suggested", "that", "diving", "with", "apparatus", "was", "related", "to", "a", "high", "risk", "health", "hazards", "the", "central", "nervous", "system", "respiro-circulatory", "system", "."], "h": {"id": "C0017373", "name": "C0017373#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011119", "name": "C0011119#ent", "pos": [11, 12]}}
{"token": ["However", ",", "there", "was", "a", "significant", "increase", "in", "gastric", "damage", "C0059865#ent", "<e1>", ",", "but", "not", "with", "C0068334#ent", "<e2>", "."], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0068334", "name": "C0068334#ent", "pos": [16, 17]}}
{"token": ["These", "observations", "suggest", "that", "C1539322#ent", "<e1>", "contain", "a", "C0724624#ent", "<e2>", "and", "that", "stria", "vascularis", "RNA", "for", "the", "subtypes", "MCT1", "and", "MCT2", "subtypes", "."], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [8, 9]}}
{"token": ["Among", "the", "most", "prominent", "of", "such", "C0079427#ent", "<e1>", "the", "Breast", "Cancer", "1", "Breast", "Cancer", "2", "genes", "BRCA1", "and", "C0598034#ent", "<e2>", ")", ",", "which", "are", "mutated", "in", "familial", "forms", "breast", "and", "ovarian", "cancer"], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0598034", "name": "C0598034#ent", "pos": [18, 19]}}
{"token": ["The", "C0085744#ent", "<e1>", "ACDs", ")", "are", "mitochondrial", "enzymes", "C0030016#ent", "<e2>", "acyl-coenzyme", "A", "esters", "different", "chain", "lengths"], "h": {"id": "C0085744", "name": "C0085744#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [8, 9]}}
{"token": ["We", "tested", "these", "five", "C0085744#ent", "<e1>", "their", "ability", "to", "C0030016#ent", "<e2>", "valproyl-CoA", "using", "pure", "enzyme", "preparations", "isolated", "from", "rat", "liver", "mitochondria", "."], "h": {"id": "C0085744", "name": "C0085744#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [9, 10]}}
{"token": ["The", "C4084896#ent", "<e1>", "the", "product", "of", "the", "C1453707#ent", "<e2>", "is", "a", "serine/threonine", "kinase"], "h": {"id": "C4084896", "name": "C4084896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1453707", "name": "C1453707#ent", "pos": [7, 8]}}
{"token": ["While", "C3710848#ent", "<e1>", "transcription", "is", "glucose", "repressible", "C3273467#ent", "<e2>", "shows", "coregulation", "with", "structural", "genes", "fatty", "acid", "biosynthesis"], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273467", "name": "C3273467#ent", "pos": [7, 8]}}
{"token": ["Absence", "of", "C3273467#ent", "<e1>", "prevented", "complete", "glucose", "repression", "C3710848#ent", "<e2>", ",", "indicating", "that", "C3273467#ent", "<e1>", "(in)directly", "is", "involved", "in", "the", "transcriptional", "regulation", "C3710848#ent", "<e2>", "."], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273467", "name": "C3273467#ent", "pos": [2, 3]}}
{"token": ["Two", "CAPS", "markers", "(", "A", "for", "C3710848#ent", "<e1>", "and", "B", "for", "C3273467#ent", "<e2>", ")", ",", "associated", "with", "amount", "of", "ethylene", "produced", ",", "were", "identified", "."], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273467", "name": "C3273467#ent", "pos": [11, 12]}}
{"token": ["Western", "blots", "that", "the", "C3710848#ent", "<e1>", "product", ",", "but", "not", "the", "C3273467#ent", "<e2>", "product", ",", "was", "degraded", "after", "a", "glucose", "pulse"], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273467", "name": "C3273467#ent", "pos": [11, 12]}}
{"token": ["To", "examine", "the", "expression", "of", "DNA-dependent", "protein", "kinase", "DNA-PK", ")", ";", "including", "DNA-PKcs", ",", "Ku70", "and", "C1337034#ent", "<e1>", "in", "human", "neuroectodermal", "tumor", "cells", "or", "without", "C0035369#ent", "<e2>", "DNA", "integration", "."], "h": {"id": "C1337034", "name": "C1337034#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035369", "name": "C0035369#ent", "pos": [25, 26]}}
{"token": ["Legionella", "sp.", "the", "etiological", "agent", "C0023241#ent", "<e1>", "the", "Pontiac", "Fever", "one", "of", "the", "new", "emerging", "C0012634#ent", "<e2>", "."], "h": {"id": "C0023241", "name": "C0023241#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["Death", "due", "to", "C0023241#ent", "<e1>", "in", "4", "cases", ":", "3", "cases", "had", "severe", "underlying", "C0012634#ent", "<e2>", ",", "and", "1", "case", "took", "18", "days", "to", "diagnose", "(", "doctors", "'", "delay", ")", "."], "h": {"id": "C0023241", "name": "C0023241#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["Of", "the", "total", ",", "22", "of", "23", "patients", "with", "C0023241#ent", "<e1>", "from", "severe", "basic", "C0012634#ent", "<e2>", "and", "complications", "(", "acute", "renal", "failure", "respiratory", "insufficiency", "etc", ".", ")"], "h": {"id": "C0023241", "name": "C0023241#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["Accurate", "monitoring", "and", "identification", "of", "Legionella", "species", "the", "causative", "agents", "C0023241#ent", "<e1>", "'", "and", "other", "C0012634#ent", "<e2>", ",", "in", "environmental", "water", "is", "an", "important", "public", "health", "."], "h": {"id": "C0023241", "name": "C0023241#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["Using", "the", "isoquinoline", "sulphonamide", "derivative", "H-8", ",", "which", "is", "a", "potent", "inhibitor", "of", "CTD", "kinase", "we", "show", "that", "C1332461#ent", "<e1>", "in", "the", "absence", "of", "C1335071#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C1332461", "name": "C1332461#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1335071", "name": "C1335071#ent", "pos": [24, 25]}}
{"token": ["Both", "the", "intact", "and", "Head-Tail", "Deltamed19(rox3", ")", "Mediator", "complexes", "defects", "in", "enhanced", "C1332461#ent", "<e1>", "enhanced", "TFIIH", "phosphorylation", "of", "the", "C1335071#ent", "<e2>", ",", "as", "well", "as", "binding", "of", "RNA", "Pol", "II", "the", "C1335071#ent", "<e2>", "."], "h": {"id": "C1332461", "name": "C1332461#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335071", "name": "C1335071#ent", "pos": [19, 20]}}
{"token": ["ELISA", "indicated", "there", "were", "normal", "amounts", "C1367553#ent", "<e1>", "and", "plasmin-alpha(2)-antiplasmin", "(", "PAP", ")", "complexes", "in", "C1866423#ent", "<e2>", "plasmas", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1866423", "name": "C1866423#ent", "pos": [15, 16]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "effects", "of", "C0003143#ent", "<e1>", "and", "ketotifen", "(", "two", "H1", "receptor", "antagonists", "on", "the", "anticonvulsant", "activity", "C0003299#ent", "<e2>", "maximal", "electroshock", "(MES)-induced", "convulsions", "in", "mice", "."], "h": {"id": "C0003143", "name": "C0003143#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [24, 25]}}
{"token": ["These", "inhibitory", "effects", "are", "attenuated", "by", "pertussis", "toxin", "suggesting", "that", "the", "inhibitory", "C1333688#ent", "<e1>", "C0001492#ent", "<e2>", "modulates", "effectors", ",", "other", "than", "C0001492#ent", "<e2>", "during", "transduction", "of", "negative", "hormonal", "signals", "."], "h": {"id": "C1333688", "name": "C1333688#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [14, 15]}}
{"token": ["The", "pneumococcus", "is", "the", "principle", "cause", "of", "C0004626#ent", "<e1>", "also", "a", "major", "cause", "of", "C0085437#ent", "<e2>"], "h": {"id": "C0004626", "name": "C0004626#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085437", "name": "C0085437#ent", "pos": [14, 15]}}
{"token": ["Streptococcus", "pneumoniae", "a", "major", "pathogenic", "organism", "of", "community-acquired", "C0004626#ent", "<e1>", "well", "as", "otitis", "media", "C0085437#ent", "<e2>"], "h": {"id": "C0004626", "name": "C0004626#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085437", "name": "C0085437#ent", "pos": [14, 15]}}
{"token": ["Further", "studies", "were", "carried", "out", "in", "hamsters", "because", ",", "in", "this", "species", ",", "adipose", "tissue", "a", "major", "site", "and", "C0023899#ent", "<e1>", "is", "a", "negligible", "site", "for", "C1706043#ent", "<e2>", "synthesis", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1706043", "name": "C1706043#ent", "pos": [26, 27]}}
{"token": ["On", "the", "other", "hand", ",", "the", "C0023899#ent", "<e1>", "is", "the", "major", "tissue", "responsible", "for", "the", "production", "of", "C1706043#ent", "<e2>", "(", "C1706043#ent", "<e2>", "mRNA", ")", "in", "rabbits", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706043", "name": "C1706043#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "seventy-five", "Iranian", "families", "segregating", "C3899988#ent", "<e1>", "non-syndromic", "hearing", "impairment", "analyzed", "for", "homozygosity", "at", "the", "C1863655#ent", "<e2>", "locus", "by", "genotyping", "two", "short", "tandem", "repeat", "markers", "linked", "to", "the", "TECTA", "gene"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1863655", "name": "C1863655#ent", "pos": [18, 19]}}
{"token": ["Both", "PMD", "and", "C2698697#ent", "<e1>", "are", "caused", "by", "mutations", "in", "the", "C1418654#ent", "<e2>", "PLP1", ")", "gene", ",", "which", "encodes", "a", "major", "component", "of", "CNS", "myelin", "proteins"], "h": {"id": "C2698697", "name": "C2698697#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418654", "name": "C1418654#ent", "pos": [11, 12]}}
{"token": ["The", "later", "expansion", "of", "the", "macrophage", "population", "bring", "about", "the", "stimulation", "of", "autoreactive", "clones", "of", "T", "and", "B", "cells", "be", "responsible", "for", "the", "C0003873#ent", "<e1>", "developed", "in", "the", "C0026936#ent", "<e2>", "treated", "mice", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0026936", "name": "C0026936#ent", "pos": [28, 29]}}
{"token": ["A", "microbiological", "and", "serologic", "investigation", "was", "carried", "out", "in", "80", "children", "with", "C0003873#ent", "<e1>", "RA", ")", "in", "order", "to", "detect", "C0026936#ent", "<e2>", "and", "Ureaplasma", "as", "possible", "causative", "agents", "RA", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026936", "name": "C0026936#ent", "pos": [20, 21]}}
{"token": ["A", "coagulopathy", "resembling", "disseminated", "C0012739#ent", "<e1>", "occur", "in", "C1858558#ent", "<e2>"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1858558", "name": "C1858558#ent", "pos": [8, 9]}}
{"token": ["Addition", "of", "morpholinomethyl", "substituents", "to", "C0034738#ent", "<e1>", "(", "ICRF-159", ")", "produced", "a", "compound", "(", "bis-4-morpholinomethyl-3,5-dioxopiperazinyl-1,2-propane", "(", "C0631231#ent", "<e2>", ")", "considerably", "more", "water-soluble", "than", "C0034738#ent", "<e1>", "."], "h": {"id": "C0631231", "name": "C0631231#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034738", "name": "C0034738#ent", "pos": [5, 6]}}
{"token": ["It", "is", "concluded", "that", "blood", "glucose", "modulate", "RES", "C0031306#ent", "<e1>", "that", "the", "C0020616#ent", "<e2>", "of", "endotoxin", "shock", "augment", "the", "shock", "state", "to", "impairment", "of", "RES", "host", "defense", "clearance", "functions", "."], "h": {"id": "C0031306", "name": "C0031306#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [12, 13]}}
{"token": ["Depression", "of", "the", "C0031306#ent", "<e1>", "the", "reticuloendothelial", "system", "RES", ")", "during", "C0020616#ent", "<e2>", "been", "implicated", "in", "the", "pathogenesis", "of", "endotoxin", "shock"], "h": {"id": "C0031306", "name": "C0031306#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [11, 12]}}
{"token": ["Two", "patients", "who", "had", "lupus", "C0003280#ent", "<e1>", "but", "not", "C0024141#ent", "<e2>", "both", "with", "histories", "of", "prior", "fetal", "death", "also", "had", "high", "antibody", "levels", ";", "fetal", "death", "in", "one", ",", "and", "spontaneous", "fetal", "bradycardia", "the", "other", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [9, 10]}}
{"token": ["Antiprothrombinase", "is", "the", "most", "frequent", "circulating", "C0003280#ent", "<e1>", "found", "in", "C0024141#ent", "<e2>", "(", "5", "to", "10", "p.", "100", ")", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "the", "effects", "of", "Triton", "X-100", "C0007901#ent", "<e1>", "on", "the", "electrochemical", ",", "spectroscopic", "and", "C1705075#ent", "<e2>", "properties", "of", "these", "compounds", "are", "reported", "."], "h": {"id": "C0007901", "name": "C0007901#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705075", "name": "C1705075#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "male", "neonate", ",", "born", "to", "a", "mother", "with", "C1527336#ent", "<e1>", "who", "experienced", "cutaneous", "lupus", "lesions", "and", "2", "episodes", "of", "C0030312#ent", "<e2>", "."], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [22, 23]}}
{"token": ["2", ")", "Traditionally", ",", "muscarinic", "antagonists", "been", "the", "pharmacological", "agents", "choice", "for", "the", "treatment", "of", "sialorrhoea", ";", "however", ",", "these", "C0991617#ent", "<e1>", "are", "frequently", "associated", "with", "adverse", "events", "patients", "with", "C0242422#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [30, 31]}}
{"token": ["Both", "C0991617#ent", "<e1>", "show", "efficacy", "in", "a", "variety", "of", "animal", "models", "epilepsy", ",", "C0242422#ent", "<e2>", "and", "cerebral", "ischaemia"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [13, 14]}}
{"token": ["Responses", "to", "C0039052#ent", "<e1>", "the", "catechol", "nucleus", "phenylephrine", ",", "synephrine", ",", "C0025681#ent", "<e2>", ")", "were", "potentiated", "inconsistently", "by", "the", "steroids", "and", "reserpine", "pretreatment", "reduced", "markedly", "the", "frequency", "of", "potentiated", "responses.3", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025681", "name": "C0025681#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "CU", "32", "-", "085", "and", "bromocriptine", "on", "dose-response", "curves", "to", "C0039052#ent", "<e1>", "adrenaline", ",", "noradrenaline", ",", "C0025681#ent", "<e2>", "and", "clonidine", ")", ",", "intravenously", "administered", ",", "were", "also", "studied", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025681", "name": "C0025681#ent", "pos": [19, 20]}}
{"token": ["Activation", "of", "NHE", "was", "much", "more", "sensitive", "to", "the", "phosphatidylcholine-specific", "phospholipase", "inhibitor", "C0148944#ent", "<e1>", ")", "than", "was", "C1366882#ent", "<e2>", "."], "h": {"id": "C0148944", "name": "C0148944#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [17, 18]}}
{"token": ["Possible", "targets", "for", "C1412228#ent", "<e1>", "and", "glutamate", "are", "the", "recently", "identified", "clock", "genes", "C3273591#ent", "<e2>", "and", "Per2", ",", "which", "are", "induced", "in", "the", "SCN", "by", "light", ",", "glutamate", "and", "C1412228#ent", "<e1>", "at", "night", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273591", "name": "C3273591#ent", "pos": [13, 14]}}
{"token": ["In", "the", "model", ",", "we", "examined", "the", "effects", "of", "C1412228#ent", "<e1>", "glutamate", "alone", "and", "in", "combination", "on", "C3273591#ent", "<e2>", "and", "per2", "gene", "expression", "late", "subjective", "night", "circadian", "time", "19", ")", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273591", "name": "C3273591#ent", "pos": [17, 18]}}
{"token": ["Mutations", "in", "the", "C0362046#ent", "<e1>", "db", ")", "gene", "result", "obesity", "and", "C0011849#ent", "<e2>", "in", "a", "syndrome", "resembling", "morbid", "human", "obesity", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}}
{"token": ["One", "group", "was", "C0362046#ent", "<e1>", "normal", "controls", ",", "and", "two", "groups", "had", "C0011849#ent", "<e2>", "experimentally", "induced", "with", "streptozotocin", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [12, 13]}}
{"token": ["Increased", "expression", "of", "IRF-1", "and", "C1426207#ent", "<e1>", "was", "observed", "in", "granulocytes", "and", "of", "SOCS-3", "and", "C0669372#ent", "<e2>", "in", "PBMC", "."], "h": {"id": "C1426207", "name": "C1426207#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [15, 16]}}
{"token": ["Among", "the", "45", "renal", "cell", "cancer", "patients", ",", "27", "carried", "at", "least", "one", "functional", "GSTM1", "gene", "C1333715#ent", "<e1>", "+", ")", "and", "18", "at", "least", "one", "functional", "C1447799#ent", "<e2>", "C1333715#ent", "<e1>", "+", ")", "."], "h": {"id": "C1333715", "name": "C1333715#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447799", "name": "C1447799#ent", "pos": [26, 27]}}
{"token": ["Individuals", "with", "a", "homozygous", "deletion", "of", "the", "C1333715#ent", "<e1>", "C1447799#ent", "<e2>", ")", "gene", "lack", "C1447799#ent", "<e2>", "enzymatic", "detoxification", "of", "environmental", "carcinogens", "by", "conjugation", "with", "glutathione", "."], "h": {"id": "C1333715", "name": "C1333715#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447799", "name": "C1447799#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "all", "DEB-sensitive", "individuals", "were", "of", "the", "C1333715#ent", "<e1>", "null", "genotype", "while", "all", "DEB-resistant", "persons", "had", "a", "detectable", "C1447799#ent", "<e2>"], "h": {"id": "C1333715", "name": "C1333715#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447799", "name": "C1447799#ent", "pos": [19, 20]}}
{"token": ["The", "whole-blood", "lymphocyte", "cultures", "showed", "lower", "replication", "indices", "the", "C1333715#ent", "<e1>", "null", "subjects", "than", "for", "those", "having", "the", "C1447799#ent", "<e2>", "both", "concentrations", "of", "DEB", "."], "h": {"id": "C1333715", "name": "C1333715#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447799", "name": "C1447799#ent", "pos": [18, 19]}}
{"token": ["C0077768#ent", "<e1>", "is", "indicated", "for", "the", "topical", "management", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0077768", "name": "C0077768#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "the", "ocular", "hypotensive", "efficacy", "and", "safety", "of", "dorzolamide", "when", "added", "to", "C0077768#ent", "<e1>", "or", "timolol", "in", "patients", "with", "uncontrolled", "C0017612#ent", "<e2>", "POAG", ")", "."], "h": {"id": "C0077768", "name": "C0077768#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [21, 22]}}
{"token": ["Many", "physicians", "recommend", "either", "C0077768#ent", "<e1>", "or", "latanoprost", "as", "firstline", "therapy", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0077768", "name": "C0077768#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "pathways", "regulating", "the", "activities", "of", "C0008163#ent", "<e1>", "and", "one", "particular", "mitogen-activated", "protein", "kinase", "C0752312#ent", "<e2>", ",", "are", "involved", "in", "the", "prolonged", "hyperexpression", "of", "CD40L", "in", "lupus", "T", "cells"], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [15, 16]}}
{"token": ["We", "also", "show", "that", "both", "C0008163#ent", "<e1>", "and", "Gab1", "enhance", "Met-induced", "activation", "of", "another", "MAP", "kinase", "cascade", "the", "C0752312#ent", "<e2>", "pathway", ",", "in", "a", "Crk-independent", "manner", "."], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "pathways", "regulating", "the", "activities", "of", "C0008163#ent", "<e1>", "and", "one", "particular", "C0752312#ent", "<e2>", "ERK", ",", "are", "involved", "in", "the", "prolonged", "hyperexpression", "of", "CD40L", "in", "lupus", "T", "cells"], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [12, 13]}}
{"token": ["Increase", "both", "of", "Sp100", "and", "C0023524#ent", "<e1>", "mRNA", "is", "due", "to", "enhanced", "transcription", "of", "the", "corresponding", "C0017337#ent", "<e2>", "which", "occurs", "independently", "of", "cellular", "protein", "synthesis", "upon", "IFN-beta", "addition", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["Molecular", "cloning", "sequence", "analysis", "the", "C0023524#ent", "<e1>", "C0017337#ent", "<e2>", "demonstrated", "a", "complex", "splicing", "pattern", "this", "C0017337#ent", "<e2>", "may", "encode", "a", "transcription", "factor"], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}}
{"token": ["Rostafuroxin", "(", "PST", "2238", ")", "is", "a", "novel", "C0003364#ent", "<e1>", "to", "selectively", "antagonize", "EO/Ouabain", "and", "C1412230#ent", "<e2>", "hypertensive", "effect", "and", "Ouabain-induced", "cardiac", "hypertrophy", "in", "rats", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412230", "name": "C1412230#ent", "pos": [15, 16]}}
{"token": ["Rostafuroxin", "(", "PST", "2238", ")", "is", "a", "new", "C0003364#ent", "<e1>", "to", "selectively", "antagonize", "EO", ",", "C1412230#ent", "<e2>", "pressor", ",", "and", "molecular", "effects"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412230", "name": "C1412230#ent", "pos": [15, 16]}}
{"token": ["The", "fraction", "of", "C0073571#ent", "<e1>", "metabolised", "to", "C0073571#ent", "<e1>", "excreted", "in", "urine", "was", "decreased", "in", "the", "itraconazole", "phase"], "h": {"id": "C0073571", "name": "C0073571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073571", "name": "C0073571#ent", "pos": [3, 4]}}
{"token": ["Activation", "of", "C0380241#ent", "<e1>", "required", "for", "LPS-", "or", "PGN-induced", "C1504688#ent", "<e2>", ",", "but", "the", "p38-responsive", "promoter", "elements", "localized", "to", "distinct", "regions", "of", "the", "sIL-1Ra", "gene"], "h": {"id": "C0380241", "name": "C0380241#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1504688", "name": "C1504688#ent", "pos": [9, 10]}}
{"token": ["Notably", ",", "the", "palmitoylation-deficient", "KAI1/CD82", "mutant", "largely", "reversed", "the", "C2987364#ent", "<e1>", "KAI1/CD82", "'s", "inhibitory", "effects", "on", "migration", "and", "invasion", "of", "C1366526#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [20, 21]}}
{"token": ["The", "hyperimmunoglobulinemia", "D", "periodic", "fever", "syndrome", "C0398691#ent", "<e1>", ")", "is", "an", "autosomal", "recessively", "inherited", "C0751422#ent", "<e2>", "by", "mutations", "in", "the", "mevalonate", "kinase", "MVK", ")", "gene", "on", "chromosome", "12q24", "which", "lead", "to", "a", "depressed", "enzymatic", "activity", "mevalonate", "kinase", "MK", ")", "."], "h": {"id": "C0398691", "name": "C0398691#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751422", "name": "C0751422#ent", "pos": [14, 15]}}
{"token": ["This", "molecule", ",", "termed", "C0912403#ent", "<e1>", "appears", "to", "represent", "the", "human", "C1334043#ent", "<e2>", "of", "the", "osteoclast-expressed", "rabbit", "cathepsin", "OC-2", "."], "h": {"id": "C0912403", "name": "C0912403#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}}
{"token": ["Protein", "phosphatase-2A", "C1704708#ent", "<e1>", ")", "is", "one", "of", "the", "major", "cellular", "C0031686#ent", "<e2>", "is", "involved", "in", "the", "regulation", "of", "cell", "homeostasis", "the", "negative", "regulation", "of", "signaling", "pathways", "by", "protein", "kinases"], "h": {"id": "C1704708", "name": "C1704708#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [11, 12]}}
{"token": ["C1419310#ent", "<e1>", ",", "but", "not", "C1539219#ent", "<e2>", "or", "TSPY", ",", "has", "a", "Y-linked", "homologue", "in", "marsupials", "which", "is", "transcribed", "in", "the", "testis", "."], "h": {"id": "C1419310", "name": "C1419310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539219", "name": "C1539219#ent", "pos": [5, 6]}}
{"token": ["These", "findings", "suggest", "that", "the", "Gla-domain", "of", "C0015518#ent", "<e1>", "Xa", ")", "is", "pivotal", "in", "the", "protection", "of", "factor", "Va", "C0162832#ent", "<e2>", "."], "h": {"id": "C0015518", "name": "C0015518#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162832", "name": "C0162832#ent", "pos": [19, 20]}}
{"token": ["Expression", "of", "innate", "immune", "genes", "as", "C0887942#ent", "<e1>", "is", "induced", "in", "airway", "epithelium", "by", "C1136365#ent", "<e2>", "activation", "of", "NF-kappaB."], "h": {"id": "C0887942", "name": "C0887942#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [14, 15]}}
{"token": ["Small", "granules", "horseshoe", "crab", "hemocytes", "contain", "two", "known", "major", "antimicrobial", "substances", "tachyplesin", "and", "big", "C0887942#ent", "<e1>", "(", "S5", ")", ",", "and", "at", "least", "five", "C1136365#ent", "<e2>", "S1", "to", "S6", ")", ",", "with", "unknown", "functions", "."], "h": {"id": "C0887942", "name": "C0887942#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [24, 25]}}
{"token": ["Among", "the", "enterobacteria", ",", "Proteus", "mirabilis", "C0302358#ent", "<e1>", "and", "two", "C0036117#ent", "<e2>", "lysed", "by", "the", "phages", "."], "h": {"id": "C0302358", "name": "C0302358#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [10, 11]}}
{"token": ["Restriction", "fragments", "by", "two", "C0014230#ent", "<e1>", "were", "comparatively", "analyzed", "by", "visualization", "of", "C0019873#ent", "<e2>", "gels", "as", "well", "as", "by", "membrane", "hybridization", "nick-translated", "DNA", "probes", "of", "plasmid-like", "S1", "and", "S2", "DNA", "."], "h": {"id": "C0014230", "name": "C0014230#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019873", "name": "C0019873#ent", "pos": [12, 13]}}
{"token": ["The", "sum", "of", "the", "sizes", "of", "the", "10", "major", "C0014230#ent", "<e1>", "fragments", ",", "detected", "by", "C0019873#ent", "<e2>", "was", "3,880", "bp", "."], "h": {"id": "C0014230", "name": "C0014230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019873", "name": "C0019873#ent", "pos": [15, 16]}}
{"token": ["In", "LPS-stimulated", "C0669365#ent", "<e1>", "and", "Kupffer", "cells", "the", "efficient", "maintenance", "of", "C1260386#ent", "<e2>", "is", "consistent", "with", "upregulated", "production", "of", "reducing", "power", "through", "the", "hexose", "phosphate", "shunt", "previously", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [11, 12]}}
{"token": ["Next", "will", "be", "clarification", "of", "the", "roles", "of", "surfactant", "proteins", "disease", "markers", "a", "variety", "of", "C0263661#ent", "<e1>", "such", "as", "C0029410#ent", "<e2>", "inflammatory", "problems"], "h": {"id": "C0263661", "name": "C0263661#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029410", "name": "C0029410#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "PKK", "is", "a", "member", "of", "the", "RICK/RIP", "family", "of", "C0031727#ent", "<e1>", ",", "which", "is", "involved", "in", "a", "C1565919#ent", "<e2>", "NF-kappa", "B", "signaling", "pathway", "is", "independent", "of", "Bcl10", "and", "IKK", "gamma"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1565919", "name": "C1565919#ent", "pos": [21, 22]}}
{"token": ["A", "variety", "of", "targets", "of", "the", "C0133930#ent", "<e1>", "been", "implicated", "in", "cell", "survival", "including", "the", "C0206354#ent", "<e2>", "GSK-3beta", ")", "."], "h": {"id": "C0133930", "name": "C0133930#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0206354", "name": "C0206354#ent", "pos": [15, 16]}}
{"token": ["The", "C1667078#ent", "<e1>", "such", "as", "cathepsin", "B", "and", "aspartic", "proteases", "such", "as", "C0007427#ent", "<e2>", "also", "play", "a", "role", "in", "invasive-ness", "of", "ovarian", "cancer", "."], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [12, 13]}}
{"token": ["This", "indicates", "the", "activation", "of", "C0031671#ent", "<e1>", "the", "liver", "in", "C0020550#ent", "<e2>", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [10, 11]}}
{"token": ["Placental", "leucine", "aminopeptidase", "P-LAP", ")", ",", "which", "is", "also", "called", "cystine", "aminopeptidase", "is", "the", "only", "C1412409#ent", "<e1>", "to", "functionally", "degrade", "OT", "as", "C0030098#ent", "<e2>", "(", "OTase", ")", "."], "h": {"id": "C1412409", "name": "C1412409#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030098", "name": "C0030098#ent", "pos": [22, 23]}}
{"token": ["The", "properties", "of", "the", "enzyme", "were", "distinct", "from", "those", "of", "well-characterized", "leucyl", "aminopeptidase", "EC", "3.4.11.1", ",", "C1412409#ent", "<e1>", "EC", "3.4.11.2", ")", "and", "primate", "C0030098#ent", "<e2>", "EC", "3.4.11.3", ")", "."], "h": {"id": "C1412409", "name": "C1412409#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030098", "name": "C0030098#ent", "pos": [23, 24]}}
{"token": ["Soluble", "CD23", "(", "C3273108#ent", "<e1>", ")", "release", "was", "enhanced", "in", "a", "dose-dependent", "manner", "by", "C3463871#ent", "<e2>", "or", "IL-4", "."], "h": {"id": "C3273108", "name": "C3273108#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3463871", "name": "C3463871#ent", "pos": [14, 15]}}
{"token": ["C3273108#ent", "<e1>", "levels", "were", "enhanced", "after", "the", "addition", "of", "C3463871#ent", "<e2>", "or", "IL-4", "(", "10", "U/ml", ")", "up", "to", "10-fold", "compared", "to", "spontaneous", "expression", "."], "h": {"id": "C3273108", "name": "C3273108#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3463871", "name": "C3463871#ent", "pos": [9, 10]}}
{"token": ["Both", "A112D", "and", "V326I", "were", "homozygous", "in", "both", "patients", "and", "lie", "on", "a", "variant", "of", "the", "minor", "C0002085#ent", "<e1>", "of", "the", "C1366631#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1366631", "name": "C1366631#ent", "pos": [21, 22]}}
{"token": ["C0002085#ent", "<e1>", "and", "genotype", "frequencies", "of", "the", "C1366631#ent", "<e2>", "polymorphism", "differed", "between", "the", "two", "study", "groups", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366631", "name": "C1366631#ent", "pos": [7, 8]}}
{"token": ["Though", "Staphylococcus", "aureus", "Clostridium", "are", "the", "usual", "C0035064#ent", "<e1>", "which", "cause", "either", "pyomyositis", "or", "C0238124#ent", "<e2>", "gram-negative", "bacteria", "a", "dangerous", "and", "rarely", "suspected", "possibility", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0238124", "name": "C0238124#ent", "pos": [14, 15]}}
{"token": ["Recent", "evidence", "suggests", "that", "C0008783#ent", "<e1>", "given", "pre-operatively", "in", "C0221002#ent", "<e2>", "1", "degree", "HPT", ")", "might", "cause", "structural", "changes", "parathyroid", "glands", "while", "its", "suppressive", "effects", "the", "disease", "are", "disputable", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [9, 10]}}
{"token": ["However", ",", "C0008783#ent", "<e1>", "had", "no", "effect", "serum", "iTh", "in", "C0221002#ent", "<e2>", "patients", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [10, 11]}}
{"token": ["It", "includes", "conversion", "between", "inactive", "(", "phospho", ")", "and", "active", "(", "C0058836#ent", "<e1>", ")", "forms", "by", "a", "specific", "C0010536#ent", "<e2>", "PDHK", ")", "and", "phosphoprotein", "phosphatase", "PDHP", ")", "."], "h": {"id": "C0058836", "name": "C0058836#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "the", "C0017713#ent", "<e1>", "and", "proinsulin", "genes", "in", "parallel", "to", "C0011777#ent", "<e2>", "and", "retinoic", "acid", "both", "increased", ")", "and", "to", "T3", "(", "both", "decreased", ")", "."], "h": {"id": "C0017713", "name": "C0017713#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "evaluated", "the", "effects", "of", "NMDA", "receptor", "antagonist", "ketamine", ")", "and", "antioxidant", "(", "C0001047#ent", "<e1>", ")", "on", "ischemia-", "and", "reperfusion-induced", "activation", "of", "C0138965#ent", "<e2>"], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0138965", "name": "C0138965#ent", "pos": [23, 24]}}
{"token": ["It", "is", "concluded", "that", "long-term", "C0028066#ent", "<e1>", "treatment", "improves", "left", "ventricular", "function", "leads", "to", "regression", "of", "established", "C0340279#ent", "<e2>", "hypertrophic", "non-obstructive", "cardiomyopathy", "in", "hypertensive", "heart", "disease"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0340279", "name": "C0340279#ent", "pos": [17, 18]}}
{"token": ["GHo", "cells", "show", "increased", "levels", "of", "phosphorylated", "Akt", "and", "C4283740#ent", "<e1>", ",", "suggesting", "inactivation", "of", "this", "C1367449#ent", "<e2>"], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367449", "name": "C1367449#ent", "pos": [16, 17]}}
{"token": ["There", "is", "no", "convincing", "evidence", "to", "suggest", "that", "the", "small", "reduction", "in", "plasma", "potassium", "levels", "associated", "with", "C0541746#ent", "<e1>", "loop", "diuretic", "therapy", "to", "be", "routinely", "prevented", "by", "the", "use", "of", "C0304490#ent", "<e2>"], "h": {"id": "C0541746", "name": "C0541746#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0304490", "name": "C0304490#ent", "pos": [30, 31]}}
{"token": ["Specific", "polyclonal", "antibodies", "C0030956#ent", "<e1>", "unique", "to", "the", "C1705623#ent", "<e2>", "are", "now", "available", ",", "which", "allow", "a", "more", "precise", "localization", "of", "the", "receptor", "in", "cells", "and", "tissues", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705623", "name": "C1705623#ent", "pos": [8, 9]}}
{"token": ["C0030956#ent", "<e1>", "that", "contain", "the", "C1705623#ent", "<e2>", "motif", "compete", "Src", ",", "but", "not", "Abl", "or", "phospholipase", "C", "gamma", "SH3", "interactions", "with", "SH3-binding", "proteins", "cell", "lysates", "IC50", "=", "1", "-", "5", "microM", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705623", "name": "C1705623#ent", "pos": [5, 6]}}
{"token": ["In", "the", "intensive", "care", "many", "patients", "are", "at", "risk", "of", "developing", "C0009117#ent", "<e1>", "changes", "leading", "to", "severe", "coagulopathy", "and", "disseminated", "intravascular", "coagulation", "C0010927#ent", "<e2>", ")", "."], "h": {"id": "C0009117", "name": "C0009117#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "a", "potential", "role", "of", "C3714949#ent", "<e1>", "in", "mammalian", "C1333237#ent", "<e2>", "we", "used", "a", "combination", "of", "live", "cell", "microscopy", "microirradiation", ",", "and", "fluorescence", "recovery", "photobleaching", "analysis"], "h": {"id": "C3714949", "name": "C3714949#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [10, 11]}}
{"token": ["C1423498#ent", "<e1>", "showed", "improvement", "with", "the", "C0076829#ent", "<e2>", "treatment", "group", "P", "=", "0.042", "vs.", "placebo", ")", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [6, 7]}}
{"token": ["This", "work", "describes", "a", "paediatric", "case", "evaluated", "under", "C1423498#ent", "<e1>", "which", "a", "new", "therapeutic", "approach", "C0076829#ent", "<e2>", "(", "TPM", ")", "was", "used", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [15, 16]}}
{"token": ["We", "show", "that", "E2", "binds", "ChlR1", ",", "a", "C0920283#ent", "<e1>", "plays", "a", "role", "in", "C1419235#ent", "<e2>"], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419235", "name": "C1419235#ent", "pos": [14, 15]}}
{"token": ["However", ",", "intestinal", "epithelial", "cells", "not", "coexpress", "IL-12p40", "or", "C1421933#ent", "<e1>", "that", "are", "required", "to", "generate", "heterodimeric", "IL-12p75", ",", "C1881122#ent", "<e2>", "and", "IL-27", "."], "h": {"id": "C1421933", "name": "C1421933#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1881122", "name": "C1881122#ent", "pos": [19, 20]}}
{"token": ["The", "presence", "of", "C0795877#ent", "<e1>", "both", "ligand", "binding", "responsiveness", "to", "human", "IFN-alpha/beta", ",", "whereas", "C0795816#ent", "<e2>", "binding", "of", "Hu-IFN-gamma", ",", "but", "not", "cellular", "responsiveness", "somatic", "cell", "hybrids"], "h": {"id": "C0795877", "name": "C0795877#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0795816", "name": "C0795816#ent", "pos": [14, 15]}}
{"token": ["Based", "on", "this", "concept", "antiestrogen", "should", "initially", "regulate", "estrogen-stimulated", "telomerase", "but", "the", "C0014442#ent", "<e1>", "would", "be", "expected", "to", "be", "C0669365#ent", "<e2>", "in", "tamoxifen-resistant", "tumor", "cells", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [19, 20]}}
{"token": ["Cyclo-oxygenase", ",", "a", "key", "C0014442#ent", "<e1>", "in", "prostaglandin", "production", ",", "is", "mainly", "in", "the", "C0669365#ent", "<e2>", "COX-1", ")", "in", "gastric", "mucosa", "whereas", "leucocytes", "have", "an", "inducible", "enzyme", "COX-2", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}}
{"token": ["One", "of", "the", "volunteers", "who", "complained", "of", "nausea", "and", "vertigo", "after", "the", "administration", "of", "5", "mg", "C0812307#ent", "<e1>", ",", "showed", "the", "highest", "serum", "values", "of", "C1705456#ent", "<e2>", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705456", "name": "C1705456#ent", "pos": [25, 26]}}
{"token": ["Therefore", "we", "compared", "the", "effects", "of", "ACE-I", "lisinopril", "vs.", "the", "ARB", "C0717550#ent", "<e1>", "on", "endothelial", "dysfunction", "a", "rat", "model", "of", "C0018802#ent", "<e2>", "."], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["There", "is", "also", "some", "experience", "now", "in", "the", "use", "of", "C0717550#ent", "<e1>", "for", "patients", "with", "C0018802#ent", "<e2>", "preserved", "left", "ventricular", "systolic", "function"], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["C0164674#ent", "<e1>", "is", "a", "long-circulating", "form", "of", "adenosine", "deaminase", "C0001457#ent", "<e2>", ")", "that", "has", "been", "in", "use", "for", ">", "8", "years", "as", "replacement", "therapy", "severe", "combined", "immunodeficiency", "disease", "to", "C0001457#ent", "<e2>", "deficiency", "."], "h": {"id": "C0164674", "name": "C0164674#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [9, 10]}}
{"token": ["Treatment", "with", "C0164674#ent", "<e1>", "was", "begun", ",", "the", "biochemical", "markers", "C0001457#ent", "<e2>", "deficiency", "normalized", ",", "and", "his", "clinical", "progress", "very", "good", "without", "significant", "infections", "."], "h": {"id": "C0164674", "name": "C0164674#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "only", "the", "L-PGDS", "KO", "mice", "developed", "nephropathy", "and", "an", "C0029454#ent", "<e1>", "to", "the", "early", "stages", "C0004153#ent", "<e2>", "when", "fed", "a", "\"", "diabetogenic", "\"", "high", "fat", "diet"], "h": {"id": "C0029454", "name": "C0029454#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [18, 19]}}
{"token": ["These", "effects", "appeared", "to", "depend", "on", "the", "sequential", "cell", "protection", "by", "C0729078#ent", "<e1>", "and", "hemopoietic", "repopulation", "mediated", "by", "C1134651#ent", "<e2>", "."], "h": {"id": "C0729078", "name": "C0729078#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1134651", "name": "C1134651#ent", "pos": [18, 19]}}
{"token": ["The", "dissociation", "of", "intra-", "and", "extracellular", "domains", "desmosomal", "cadherin", "E-cadherin", "is", "characteristic", "of", "the", "acantholytic", "cells", "C0085106#ent", "<e1>", "and", "DD", ",", "and", "not", "of", "C0030807#ent", "<e2>", "."], "h": {"id": "C0085106", "name": "C0085106#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030807", "name": "C0030807#ent", "pos": [24, 25]}}
{"token": ["The", "improvement", "in", "rotarod", "performance", "suggests", "that", "C3540800#ent", "<e1>", "may", "improve", "C0426980#ent", "<e2>", "well", "as", "depression", "in", "some", "HD", "patients", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0426980", "name": "C0426980#ent", "pos": [11, 12]}}
{"token": ["C0239295#ent", "<e1>", "not", "necessarily", "imply", "the", "presence", "of", "C0006840#ent", "<e2>", "and", "conversely", ",", "C0006840#ent", "<e2>", "not", "imply", "esophageal", "candidiasis"], "h": {"id": "C0239295", "name": "C0239295#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [8, 9]}}
{"token": ["C1414360#ent", "<e1>", "is", "encoded", "by", "two", "C0017337#ent", "<e2>", "(", "TIF51A", "and", "TIF51B", ")", "in", "Saccharomyces", "cerevisiae", "the", "protein", "and", "its", "hypusine", "modification", "are", "essential", "for", "cell", "viability"], "h": {"id": "C1414360", "name": "C1414360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}}
{"token": ["Concomitant", "C1422257#ent", "<e1>", "and", "C0085624#ent", "<e2>", "well", "as", "C1422257#ent", "<e1>", "and", "pain", "were", "noted", "in", "47", "%", "and", "44", "%", "of", "the", "patients", ",", "respectively", "."], "h": {"id": "C0085624", "name": "C0085624#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422257", "name": "C1422257#ent", "pos": [1, 2]}}
{"token": ["Nettle", "sting", "evoked", "an", "irregular", "C", "fibre", "discharge", "maximum", "10", "spikes/s", ")", "accompanied", "by", "a", "pricking", "and", "C0085624#ent", "<e1>", "the", "sensation", "of", "C1422257#ent", "<e2>", "which", "was", "sometimes", "reported", ",", "was", "not", "correlated", "with", "the", "discharge", "frequency"], "h": {"id": "C0085624", "name": "C0085624#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1422257", "name": "C1422257#ent", "pos": [22, 23]}}
{"token": ["One", "subset", ",", "which", "was", "CD4(-", ")", ",", "selectively", "produced", "the", "C3540579#ent", "<e1>", "cytokines", "interferon", "gamma", "tumor", "necrosis", "factor", "alpha", "and", "expressed", "C3538763#ent", "<e2>", ",", "a", "marker", "associated", "with", "cytolysis", "of", "microbially", "infected", "and", "neoplastic", "cells"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538763", "name": "C3538763#ent", "pos": [22, 23]}}
{"token": ["Both", "proteins", "also", "interact", "with", "the", "N-terminal", "domains", "of", "obscurin-like", "1", "C1826505#ent", "<e1>", ")", ",", "a", "small", "homologue", "of", "C1423682#ent", "<e2>", "."], "h": {"id": "C1826505", "name": "C1826505#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1423682", "name": "C1423682#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "C3273629#ent", "<e1>", "increase", "in", "C0042071#ent", "<e2>", "seems", "not", "to", "be", "affected", "(", "or", "inhibited", ")", "by", "PAI-1", "in", "areas", "where", "tumor", "cells", "invading", "normal", "tissue"], "h": {"id": "C3273629", "name": "C3273629#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [8, 9]}}
{"token": ["Lymphoid", "(", "Sp2/0", ")", "and", "non-lymphoid", "(", "CHO", ")", "cell", "lines", "for", "transfection", "contained", "in", "their", "C0017428#ent", "<e1>", "a", "semisynthetic", "gene", "T7", "RNA", "polymerase", "steadily", "expressed", "this", "C0014442#ent", "<e2>", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [27, 28]}}
{"token": ["We", "conclude", "that", "induction", "of", "an", "acute-phase", "response", "experimental", "C0024530#ent", "<e1>", "Brown", "Norway", "rats", ",", "strongly", "inhibits", "liver", "schizont", "development", "and", "that", "C1334122#ent", "<e2>", "is", "a", "key", "mediator", "in", "this", "process", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334122", "name": "C1334122#ent", "pos": [22, 23]}}
{"token": ["Here", ",", "we", "have", "investigated", "whether", "a", "tyrosine", "kinase", "C1335273#ent", "<e1>", ",", "is", "functionally", "involved", "in", "C0248813#ent", "<e2>", "JNK", ")", "activation", "in", "vascular", "smooth", "muscle", "cells", "VSMCs", ")", "."], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [16, 17]}}
{"token": ["Overexpression", "of", "C1335273#ent", "<e1>", "induces", "activation", "of", "C0248813#ent", "<e2>", "also", "known", "as", "stress-activated", "protein", "kinase", ",", "mitogen-activated", "protein", "kinase", "MAPK", ")", ",", "and", "p38", "MAPK"], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [7, 8]}}
{"token": ["In", "these", "cells", ",", "PI3K", "constitutively", "associated", "with", "molecular", "adapters", "Grb2", "and", "C3813239#ent", "<e1>", ",", "and", "with", "the", "C0656342#ent", "<e2>", "SHIP", "."], "h": {"id": "C3813239", "name": "C3813239#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0656342", "name": "C0656342#ent", "pos": [18, 19]}}
{"token": ["C0019079#ent", "<e1>", ",", "cough", ",", "and", "C0032285#ent", "<e2>", "were", "the", "most", "frequent", "presenting", "complaints", "."], "h": {"id": "C0019079", "name": "C0019079#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [6, 7]}}
{"token": ["Intramuscular", "C0073631#ent", "<e1>", "is", "the", "only", "parenteral", "C0003211#ent", "<e2>", "available", "for", "analgesic", "use", "in", "the", "US", "."], "h": {"id": "C0073631", "name": "C0073631#ent", "pos": [1, 2]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [7, 8]}}
{"token": ["The", "tolerability", "profile", "of", "C0073631#ent", "<e1>", "parallels", "that", "of", "other", "C0003211#ent", "<e2>", ";", "most", "clinically", "important", "adverse", "events", "the", "gastrointestinal", "tract", "renal", "or", "haematological", "function"], "h": {"id": "C0073631", "name": "C0073631#ent", "pos": [4, 5]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}}
{"token": ["Upon", "induction", "by", "C0039512#ent", "<e1>", "(", "isopropyl-\u03b2-D", ":", "-thio-galactopyranoside", ")", ",", "the", "expressed", "C0016955#ent", "<e2>", "could", "cleave", "X-gal", "(", "5-bromo-4-choloro-3-indoyl-\u03b2-D", ":", "-galactopyranoside", ")", "and", "turn", "the", "colonies", "blue"], "h": {"id": "C0039512", "name": "C0039512#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016955", "name": "C0016955#ent", "pos": [13, 14]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "examine", "the", "effect", "of", "age-related", "C1420267#ent", "<e1>", "on", "the", "activity", "of", "plasminogen", "activator", "inhibitor", "type", "1", "C1705527#ent", "<e2>", ")", "and", "tissue", "plasminogen", "activator", "tPA", ")", "using", "muscle", "SNA", "MSNA", ")", "."], "h": {"id": "C1420267", "name": "C1420267#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705527", "name": "C1705527#ent", "pos": [23, 24]}}
{"token": ["Mutations", "in", "the", "gene", "encoding", "dysferlin", "(", "C1414209#ent", "<e1>", ")", "cause", "the", "allelic", "autosomal", "recessive", "disorders", "C0686353#ent", "<e2>", "Miyoshi", "myopathy"], "h": {"id": "C1414209", "name": "C1414209#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [16, 17]}}
{"token": ["Identical", "mutations", "in", "the", "C1414209#ent", "<e1>", "produce", "more", "than", "one", "myopathy", "phenotype", "(", "MM", ",", "C0686353#ent", "<e2>", "distal", "myopathy", "anterior", "tibial", "onset", "."], "h": {"id": "C1414209", "name": "C1414209#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [15, 16]}}
{"token": ["C3809147#ent", "<e1>", "a", "rare", "condition", "with", "a", "C1516876#ent", "<e2>", "determined", "disturbance", "of", "epidermal", "proliferation"], "h": {"id": "C3809147", "name": "C3809147#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [7, 8]}}
{"token": ["In", "31", "cases", "in", "which", "C0004135#ent", "<e1>", "yielded", "negative", "results", ",", "C0007804#ent", "<e2>", "in", "contrast", "indicated", "Al", "deposits", "on", "up", "to", "20", "%", "of", "the", "trabecular", "bone", "surface", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [11, 12]}}
{"token": ["Fenoterol", "and", "C0282210#ent", "<e1>", "markedly", "decreased", "the", "urine", "outflow", "rate", ",", "compared", "with", "C0075717#ent", "<e2>", "and", "dobutamine", "in", "the", "rats", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0075717", "name": "C0075717#ent", "pos": [13, 14]}}
{"token": ["Four", "beta-adrenoceptor", "agonists", "C0282210#ent", "<e1>", ",", "salbutamol", ",", "procaterol", "and", "alpha-(3,4,5-trimethoxyphenethylaminomethyl)-3,4-dihydroxybenzylalcohol", "hydrochloride", "(", "C0075717#ent", "<e2>", ")", ",", "all", "produced", "concentration-dependent", "relaxation", "of", "venous", "strips", "by", "10(-6", ")", "M", "methoxamine", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0075717", "name": "C0075717#ent", "pos": [13, 14]}}
{"token": ["Their", "PIEs", "were", "antagonized", "by", "atenolol", ",", "a", "selective", "beta", "1-antagonist", ",", "(", "pA2", "=", "7.71", "for", "C0282210#ent", "<e1>", "and", "pA2", "=", "7.82", "for", "C0075717#ent", "<e2>", ")", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0075717", "name": "C0075717#ent", "pos": [24, 25]}}
{"token": ["The", "C1413231#ent", "<e1>", "was", "to", "identify", "a", "novel", "selective", "PPARdelta", "C0243192#ent", "<e2>", "with", "full", "efficacy", "on", "free", "fatty", "acid", "FFA", ")", "oxidation", "in", "vitro", "plasma", "lipid", "correction", "in", "vivo"], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}}
{"token": ["With", "the", "C1413231#ent", "<e1>", "of", "the", "radiolabeling", "of", "cytisine", ",", "a", "potent", "C0243192#ent", "<e2>", "of", "nicotinic", "receptors", "with", "[(11)C]phosgene", ",", "the", "rapid", "synthesis", "of", "a", "lactam", "model", "our", "target", "has", "been", "studied", "."], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}}
{"token": ["Our", "C1413231#ent", "<e1>", "was", "to", "investigate", "if", "the", "peroxisome", "proliferator-activated", "receptor", "C0243192#ent", "<e2>", "pioglitazone", "modulates", "inflammation", "through", "PPARalpha", "mechanisms", "."], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}}
{"token": ["To", "further", "characterize", "the", "relationship", "between", "C0534137#ent", "<e1>", "inactivation", "and", "induction", ",", "several", "structurally", "diverse", "C3887938#ent", "<e2>", "analogs", "with", "varying", "C0534137#ent", "<e1>", "inactivating", "potentials", "were", "tested", "for", "their", "ability", "to", "induce", "P450", "2B"], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3887938", "name": "C3887938#ent", "pos": [15, 16]}}
{"token": ["Harman", "and", "C0068994#ent", "<e1>", "showed", "a", "much", "lower", "inhibitory", "effect", "on", "C0114645#ent", "<e2>", "activity", "."], "h": {"id": "C0068994", "name": "C0068994#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0114645", "name": "C0114645#ent", "pos": [11, 12]}}
{"token": ["US", "patents", "(", "Nos.", "6,319,926", "and", "6,444,673", ")", "have", "been", "issued", "covering", "the", "use", "of", "C1436328#ent", "<e1>", "for", "the", "treatment", "of", "C1950154#ent", "<e2>", ",", "C1436328#ent", "<e1>", "and", "pharmaceutical", "compositions", "C1436328#ent", "<e1>", "."], "h": {"id": "C1436328", "name": "C1436328#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [21, 22]}}
{"token": ["On", "discontinuation", "of", "C1436328#ent", "<e1>", ",", "there", "was", "no", "rebound", "C1950154#ent", "<e2>", "or", "serious", "withdrawal", "effects", "."], "h": {"id": "C1436328", "name": "C1436328#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [10, 11]}}
{"token": ["Editor", "'s", "note", ":", "Since", "preparation", "of", "this", "manuscript", ",", "the", "FDA", "has", "approved", "C1436328#ent", "<e1>", "for", "treatment", "of", "C1950154#ent", "<e2>", ".", ")", "."], "h": {"id": "C1436328", "name": "C1436328#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [19, 20]}}
{"token": ["In", "December", "2004", "the", "US", "FDA", "approved", "C1436328#ent", "<e1>", "(", "Lunesta", ")", "for", "the", "treatment", "of", "C1950154#ent", "<e2>", "."], "h": {"id": "C1436328", "name": "C1436328#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [16, 17]}}
{"token": ["The", "number", "of", "satellites", ",", "number", "of", "C1136365#ent", "<e1>", "amplitude", "were", "also", "significantly", "increased", "in", "the", "C0002736#ent", "<e2>", "group", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [16, 17]}}
{"token": ["In", "coeliac", "disease", "C1705969#ent", "<e1>", ")", "there", "is", "a", "C0007570#ent", "<e2>", "life-long", "adherence", "to", "a", "strict", "gluten-free", "diet", "GFD", ")", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [9, 10]}}
{"token": ["The", "wide", "variation", "in", "recovery", "of", "morphine", "and", "morphine-glucuronides", "after", "oral", "administration", "C0009214#ent", "<e1>", "could", "not", "be", "explained", "simply", "by", "a", "difference", "in", "C3887685#ent", "<e2>", "genotype", "."], "h": {"id": "C0009214", "name": "C0009214#ent", "pos": [12, 13]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "the", "O-deethylation", "of", "C0009214#ent", "<e1>", "is", "catalysed", "by", "the", "C3887685#ent", "<e2>", "in", "human", "liver", "microsomes", "consistent", "with", "previous", "findings", "in", "healthy", "volunteers"], "h": {"id": "C0009214", "name": "C0009214#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [12, 13]}}
{"token": ["Information", "concerning", "these", "signaling", "systems", "beginning", "to", "provide", "therapeutic", "strategies", "to", "manipulate", "the", "immune", "system", "overcome", "C3854222#ent", "<e1>", "HIV", ")", "infection", ",", "C0004364#ent", "<e2>", "and", "graft", "rejection"], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [22, 23]}}
{"token": ["The", "association", "of", "immune", "dysfunction", "patients", "with", "C3854222#ent", "<e1>", "HIV", ")", "infection", "and", "AIDS", "and", "the", "development", "of", "C0004364#ent", "<e2>", "intriguing", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [18, 19]}}
{"token": ["The", "role", "of", "the", "CC", "chemokine", "receptor", "CCR", ")", "1", "in", "C0014335#ent", "<e1>", "investigated", "by", "subjecting", "C1332699#ent", "<e2>", "knockout", "mice", "Clostridium", "difficile", "toxin", "A", "treatment", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332699", "name": "C1332699#ent", "pos": [16, 17]}}
{"token": ["The", "mitogen-activated", "protein", "kinase", "kinase", "inhibitor", "C0298346#ent", "<e1>", "markedly", "reduced", "induction", "of", "C1822686#ent", "<e2>", "by", "mersalyl", "but", "not", "by", "hypoxia", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1822686", "name": "C1822686#ent", "pos": [12, 13]}}
{"token": ["C0298346#ent", "<e1>", ",", "ERK", "inhibitor", "reduced", "C1822686#ent", "<e2>", "increased", "by", "TB4P", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1822686", "name": "C1822686#ent", "pos": [6, 7]}}
{"token": ["The", "chromosomal", "rearrangement", "the", "retinoic", "acid", "receptor", "alpha", "RAR", "alpha", "and", "C1366903#ent", "<e1>", "genes", ",", "resulting", "in", "C1709412#ent", "<e2>", "fusion", "transcripts", "."], "h": {"id": "C1366903", "name": "C1366903#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1709412", "name": "C1709412#ent", "pos": [17, 18]}}
{"token": ["Since", "C1426334#ent", "<e1>", "is", "the", "sole", "C2354171#ent", "<e2>", "yeast", ",", "these", "findings", "indicate", "a", "critical", "role", "of", "GCN1-GCN2", "interaction", "in", "activation", "of", "the", "kinase", "in", "vivo"], "h": {"id": "C1426334", "name": "C1426334#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2354171", "name": "C2354171#ent", "pos": [6, 7]}}
{"token": ["Polyethyleneimine", "or", "polylysines", "of", "differing", "molecular", "sizes", "were", "substituted", "with", "either", "C0012695#ent", "<e1>", "or", "DTPA", "and", "then", "with", "C0075429#ent", "<e2>", "groups", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0075429", "name": "C0075429#ent", "pos": [18, 19]}}
{"token": ["The", "crystal", "structure", "C1456345#ent", "<e1>", "acid", "binding", "protein", "(", "C1412325#ent", "<e2>", ")", "complexed", "with", "NADP(+", ")", "and", "3alpha,7beta-dihydroxy-5beta-cholanic", "acid", "ursodeoxycholate", ")", "at", "3.0", "A", "resolution", "is", "presented", "."], "h": {"id": "C1456345", "name": "C1456345#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412325", "name": "C1412325#ent", "pos": [9, 10]}}
{"token": ["To", "assess", "mechanisms", "that", "cause", "C4025163#ent", "<e1>", "rheumatoid", "arthritis", "RA", ")", ",", "we", "measured", "bone", "mineral", "density", "C1826421#ent", "<e2>", ")", "by", "dual", "photon", "absorptiometry", "the", "lumbar", "spine", "femoral", "neck", "111", "patients", "with", "RA", "."], "h": {"id": "C4025163", "name": "C4025163#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826421", "name": "C1826421#ent", "pos": [17, 18]}}
{"token": ["Unlike", "normal", "S.", "cerevisiae", "GAL4", ",", "the", "strain", "carrying", "C1706642#ent", "<e1>", "gave", "constitutive", "expression", "of", "GAL1", "and", "MEL1", ",", "two", "C1417679#ent", "<e2>", "in", "the", "regulon", "."], "h": {"id": "C1706642", "name": "C1706642#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["However", ",", "either", "the", "C1706642#ent", "<e1>", "or", "GAL4", "gene", "a", "product", "of", "these", "C1417679#ent", "<e2>", "responds", "differently", "to", "glucose", "in", "K.", "lactis", "."], "h": {"id": "C1706642", "name": "C1706642#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["A", "severe", "reduction", "in", "peritubular", "capillary", "flow", "denotes", "a", "higher", "incidence", "of", "C1367457#ent", "<e1>", "as", "that", "observed", "in", "C0027726#ent", "<e2>", "with", "FSGS", "."], "h": {"id": "C1367457", "name": "C1367457#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [18, 19]}}
{"token": ["Among", "the", "C2963170#ent", "<e1>", "surveillance", "was", "C0740441#ent", "<e2>"], "h": {"id": "C2963170", "name": "C2963170#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0740441", "name": "C0740441#ent", "pos": [6, 7]}}
{"token": ["Thus", ",", "this", "study", "demonstrated", "an", "C0003364#ent", "<e1>", "a", "single", "oral", "administration", "C0068700#ent", "<e2>", "without", "baroreflex", "activation"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0068700", "name": "C0068700#ent", "pos": [12, 13]}}
{"token": ["Our", "aim", "in", "this", "study", "was", "to", "improve", "the", "diagnosis", "of", "C1838652#ent", "<e1>", ",", "and", "to", "begin", "to", "understand", "which", "C1417679#ent", "<e2>", "are", "involved", "in", "C1838652#ent", "<e1>", "."], "h": {"id": "C1838652", "name": "C1838652#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["The", "antiestrogens", "E-", "and", "C0546859#ent", "<e1>", "blocked", "the", "protein", "induction", "C2757070#ent", "<e2>", ",", "either", "alone", "or", "in", "combination", "with", "estrogen", ",", "was", "ineffective", "in", "modulating", "the", "induction", "."], "h": {"id": "C0546859", "name": "C0546859#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [10, 11]}}
{"token": ["C0746668#ent", "<e1>", "a", "common", "complaint", "among", "patients", "who", "seek", "care", "for", "C0009326#ent", "<e2>"], "h": {"id": "C0746668", "name": "C0746668#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [11, 12]}}
{"token": ["Thus", "C1419407#ent", "<e1>", "activates", "proliferation", "of", "normal", "fibroblasts", "through", "stimulation", "of", "C0086661#ent", "<e2>", "phosphorylation", "without", "affecting", "ERK1/2", "activity", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [11, 12]}}
{"token": ["We", "report", "in", "the", "present", "study", "on", "another", "protein", ",", "Tiam1", ",", "which", "is", "a", "specific", "guanine", "nucleotide", "exchange", "factor", "C1419407#ent", "<e1>", "and", "which", "binds", "to", "C0086661#ent", "<e2>", "and", "modulates", "several", "of", "its", "biological", "functions"], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [26, 27]}}
{"token": ["We", "also", "show", "that", "Stat3", "is", "required", "for", "C1419407#ent", "<e1>", "induction", "of", "C0086661#ent", "<e2>", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [12, 13]}}
{"token": ["The", "C2827557#ent", "<e1>", "of", "potencies", "was", "C0020223#ent", "<e2>", "greater", "than", "dihydralazine", "greater", "than", "endralazine", "."], "h": {"id": "C2827557", "name": "C2827557#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [6, 7]}}
{"token": ["Solubilization", "of", "egg", "yolk", "C3811118#ent", "<e1>", "occurs", "in", "C0012066#ent", "<e2>", "between", "2", "and", "3", "M", "and", "in", "Na-tribromoacetate", "between", "1.5", "and", "2", "M."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012066", "name": "C0012066#ent", "pos": [8, 9]}}
{"token": ["Extracts", "from", "purified", "human", "basophils", "revealed", "activity", "of", "C0000359#ent", "<e1>", "with", "a", "km-value", "of", "0.59", "microM.", "The", "C0014442#ent", "<e2>", "was", "not", "activated", "by", "Ca-ions", "."], "h": {"id": "C0000359", "name": "C0000359#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Detergent", "solubilisation", "of", "particulate", "rat", "liver", "low", "C0000359#ent", "<e1>", "the", "presence", "of", "protease", "inhibitors", "a", "form", "of", "the", "C0014442#ent", "<e2>", "with", "a", "larger", "molecular", "weight", "the", "form", "solubilised", "by", "protease", "treatment", "."], "h": {"id": "C0000359", "name": "C0000359#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [18, 19]}}
{"token": ["In", "fetal", "blood", "total", "absence", "of", "HbA", "and", "HbF", ",", "presence", "of", "Hb", "Bart", "'s", ",", "Hb", "Portland", "C2697530#ent", "<e1>", "argued", "in", "favor", "of", "C0002312#ent", "<e2>"], "h": {"id": "C2697530", "name": "C2697530#ent", "pos": [18, 19]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002312", "name": "C0002312#ent", "pos": [24, 25]}}
{"token": ["We", "have", "found", "four", "types", "of", "defects", "in", "the", "alpha-thalassemia-2", "genetic", "determinant", "-alpha", "3.7", "type", "I", "-alpha", "4.2", ";", "alpha", "CS", "alpha", "and", "alpha", "alpha", "T.", "C2697530#ent", "<e1>", "subjects", "carried", "the", "--SEA", "genotype", "in", "the", "C0002312#ent", "<e2>"], "h": {"id": "C2697530", "name": "C2697530#ent", "pos": [26, 27]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002312", "name": "C0002312#ent", "pos": [35, 36]}}
{"token": ["Five", "out", "of", "6", "(", "83.3", "%", ")", "proven", "and", "4", "out", "of", "5", "(", "80", "%", ")", "presumptive", "C0018013#ent", "<e1>", "sera", "reacted", "with", "these", "specific", "C0848332#ent", "<e2>", "."], "h": {"id": "C0018013", "name": "C0018013#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0848332", "name": "C0848332#ent", "pos": [26, 27]}}
{"token": ["C0541746#ent", "<e1>", "equivalent", "to", "1", "to", "2", "mg/kg/d", "of", "hydrochlorothiazide", "(", "C0020261#ent", "<e2>", ")", "have", "been", "proposed", "to", "correct", "hypercalciuria", "and", "prevent", "kidney", "failure", "patients", "with", "Dent", "disease"], "h": {"id": "C0541746", "name": "C0541746#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [11, 12]}}
{"token": ["The", "hemodynamic", "and", "neurohumoral", "responses", "of", "21", "C0541746#ent", "<e1>", "hypertensives", "who", "had", "received", "sequential", "chronic", "therapy", "C0020261#ent", "<e2>", ",", "C0020261#ent", "<e2>", "combined", "with", "bevantolol", "and", "bevantolol", "monotherapy", "were", "compared", "."], "h": {"id": "C0541746", "name": "C0541746#ent", "pos": [7, 8]}, "relation": "chemical_structure_of", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [16, 17]}}
{"token": ["Preosteoclasts", "(", "pOCs", ")", "and", "OCs", "were", "characterized", "by", "their", "ultrastructure", "and", "the", "expression", "of", "C1412791#ent", "<e1>", "markers", "such", "as", "C0297331#ent", "<e2>", "TRAP", ")", "and", "vacuolar-type", "H(+)-ATPase"], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0297331", "name": "C0297331#ent", "pos": [20, 21]}}
{"token": ["There", "was", "a", "significant", "increase", "of", "C1412791#ent", "<e1>", "(", "Gla", ")", "osteocalcin", ",", "bone", "alkaline", "phosphatase", "B-ALP", ")", ",", "C0297331#ent", "<e2>", "TRACP", ")", ",", "and", "cross-linked", "N-terminal", "telopeptide", "of", "type", "1", "collagen", "NTx", ")", "levels", "after", "vitamin", "K2", "administration", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0297331", "name": "C0297331#ent", "pos": [19, 20]}}
{"token": ["They", "could", "not", "be", "ascribed", "to", "acquired", "C0853888#ent", "<e1>", "or", "to", "a", "C1704321#ent", "<e2>"], "h": {"id": "C0853888", "name": "C0853888#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [12, 13]}}
{"token": ["Corticosteroid", "therapy", "been", "demonstrated", "to", "be", "effective", "for", "treating", "patients", "with", "septic", "shock", "late-phase", "acute", "respiratory", "distress", "syndrome", "ARDS", ")", ",", "or", "C0405580#ent", "<e1>", "and", "the", "use", "of", "corticosteroid", "in", "C0221423#ent", "<e2>", "recently", "increased", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [30, 31]}}
{"token": ["C0004480#ent", "<e1>", ",", "an", "inhibitor", "of", "C0017787#ent", "<e2>", "provoked", "an", "increase", "in", "enzymatic", "activity", "suggesting", "that", "glutamine", "is", "not", "involved", "in", "GS", "regulation", "."], "h": {"id": "C0004480", "name": "C0004480#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017787", "name": "C0017787#ent", "pos": [6, 7]}}
{"token": ["In", "the", "presence", "of", "C0004480#ent", "<e1>", ",", "an", "inhibitor", "of", "C0017787#ent", "<e2>", "glutamate", "was", "initially", "more", "highly", "labelled", "than", "any", "other", "amino", "acid", "whereas", "its", "concentration", "declined", "."], "h": {"id": "C0004480", "name": "C0004480#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017787", "name": "C0017787#ent", "pos": [10, 11]}}
{"token": ["A", "diffuse", "interstitial", "pulmonary", "fibrosis", "associated", "with", "idiopathic", "hepatic", "cirrhosis", "in", "a", "79", "years", "old", "man", "treated", "during", "five", "years", "with", "cyclothiazide", "and", "C0040869#ent", "<e1>", "for", "a", "C0020538#ent", "<e2>"], "h": {"id": "C0040869", "name": "C0040869#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [27, 28]}}
{"token": ["The", "mutagenic", "response", "of", "L5178Y", "mouse", "lymphoma", "cells", "the", "model", "aromatic", "amine", "carcinogens", "benzidine", "(", "BNZ", ")", "and", "C0045883#ent", "<e1>", "(", "2-AF", ")", "in", "the", "presence", "of", "the", "mammalian", "C0033551#ent", "<e2>", "PHS", ")", "was", "examined", "."], "h": {"id": "C0045883", "name": "C0045883#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [29, 30]}}
{"token": ["By", "contrast", ",", "classical", "presentations", "of", "C0037315#ent", "<e1>", "children", ",", "such", "as", "C0037384#ent", "<e2>", "and", "obstructive", "sleep", "apnoea", "well", "as", "their", "clinical", "implications", "have", "been", "greatly", "neglected", "and", "underestimated", "in", "the", "past", "."], "h": {"id": "C0037315", "name": "C0037315#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0037384", "name": "C0037384#ent", "pos": [12, 13]}}
{"token": ["The", "in", "vitro", "effect", "of", "the", "C0042402#ent", "<e1>", "dipyridamole", ",", "nifedipine", ",", "C0033059#ent", "<e2>", "and", "glyceryl", "di-", ",", "tri-", "and", "tetranitrate", "on", "the", "oxygen", "saturation", "curve", "human", "hemoglobin", "(", "Hb", ")", "was", "evaluated", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033059", "name": "C0033059#ent", "pos": [12, 13]}}
{"token": ["C0042402#ent", "<e1>", "selectively", "the", "large", "arteries", ",", "while", "adenosine", ",", "C0033059#ent", "<e2>", "and", "carbochromen", "dilated", "the", "small", "arteries"], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033059", "name": "C0033059#ent", "pos": [10, 11]}}
{"token": ["The", "system", "consists", "of", "an", "extremely", "C0012888#ent", "<e1>", "Pfu", ")", ",", "and", "a", "buffer", "supplemented", "with", "ammonium", "sulfate", "C0012403#ent", "<e2>"], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012403", "name": "C0012403#ent", "pos": [18, 19]}}
{"token": ["A", "significant", "portion", "of", "protein", "X", "retained", "with", "the", "C0074366#ent", "<e1>", "core", "following", "release", "of", "virtually", "all", "the", "C0031727#ent", "<e2>", "."], "h": {"id": "C0074366", "name": "C0074366#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}}
{"token": ["C1417679#ent", "<e1>", "that", "encode", "NeuroD", ",", "Beta3", ",", "Oligo", ",", "C0796355#ent", "<e2>", ",", "NSCL", ",", "SRC", ",", "Clock", "and", "Bmal", "were", "not", "found", "in", "the", "Ciona", "genome", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0796355", "name": "C0796355#ent", "pos": [10, 11]}}
{"token": ["P-Glycoprotein", "(", "C1422070#ent", "<e1>", ")", "expression", "in", "cell", "lines", "from", "tumors", "arising", "from", "cells", "which", "normally", "express", "C1422070#ent", "<e1>", "can", "be", "increased", "by", "sodium", "butyrate", "other", "differentiating", "C0035064#ent", "<e1>", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [27, 28]}}
{"token": ["A", "variety", "of", "compounds", "(", "chemosensitizing", "agents", "can", "interfere", "with", "C1422070#ent", "<e1>", "and", "MRP", "function", ";", "such", "C0035064#ent", "<e2>", "may", "improve", "the", "efficacy", "of", "conventional", "therapy", "used", "in", "combination", "with", "such", "regimens", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}}
{"token": ["In", "the", "pithed", "normotensive", "rat", ",", "the", "stimulation-induced", "increase", "in", "diastolic", "blood", "pressure", "C3813197#ent", "<e1>", ")", "as", "well", "as", "the", "C0051844#ent", "<e2>", "II-elicited", "C3813197#ent", "<e1>", "response", "were", "dose-dependently", "reduced", "by", "all", "the", "AT1", "receptor", "blockers", "investigated", "."], "h": {"id": "C3813197", "name": "C3813197#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [20, 21]}}
{"token": ["Stimulation", "of", "C1333711#ent", "<e1>", "with", "glutamate", ",", "C0080073#ent", "<e2>", ",", "or", "ACPD", "rapidly", "increased", "secretion", "of", "the", "APP", "ectodomain", "(", "APPs", ")", ";", "these", "effects", "were", "blocked", "by", "MCPG", "."], "h": {"id": "C1333711", "name": "C1333711#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0080073", "name": "C0080073#ent", "pos": [7, 8]}}
{"token": ["These", "t-ACPD", "responses", "showed", "several", "characteristics", "identical", "to", "those", "of", "the", "other", "metabotropic", "responses", "including", "the", "C1333711#ent", "<e1>", "stimulated", "by", "C0080073#ent", "<e2>", "."], "h": {"id": "C1333711", "name": "C1333711#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0080073", "name": "C0080073#ent", "pos": [20, 21]}}
{"token": ["This", "study", "has", "demonstrated", "the", "mechanism", "of", "C0010531#ent", "<e1>", "inhibition", "of", "astrocytic", "nitric", "oxide", "production", "and", "inducible", "C1538973#ent", "<e2>", "mRNA", "expression", "induced", "by", "lipopolysaccharide", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538973", "name": "C1538973#ent", "pos": [17, 18]}}
{"token": ["Tryptophanyl-tRNA", "synthetase", "C0041256#ent", "<e1>", ",", "heterogeneous", "nuclear", "ribonucleoprotein", "JKTBP", "interferon-induced", "35kDa", "protein", "proteasome", "subunit", "LMP2", "arginosuccinate", "synthetase", "identified", "as", "C1333196#ent", "<e2>", "modulated", "proteins", "in", "vitro"], "h": {"id": "C0041256", "name": "C0041256#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [19, 20]}}
{"token": ["C3541418#ent", "<e1>", "and", "Sis1", "could", "both", "functionally", "interact", "with", "C2986652#ent", "<e2>", ",", "but", "not", "the", "Ssb1/2", "proteins", ",", "to", "refold", "luciferase", "."], "h": {"id": "C3541418", "name": "C3541418#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2986652", "name": "C2986652#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "C3541418#ent", "<e1>", "appears", "more", "efficient", "at", "assisting", "C2986652#ent", "<e2>", "in", "folding", "luciferase", "its", "contains", "a", "zinc", "finger-like", "region", "that", "is", "absent", "from", "Sis1", "."], "h": {"id": "C3541418", "name": "C3541418#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2986652", "name": "C2986652#ent", "pos": [9, 10]}}
{"token": ["Particle", "deposition", "C0027424#ent", "<e1>", "not", "significantly", "different", "from", "the", "values", "before", "application", "of", "C0078643#ent", "<e2>", "."], "h": {"id": "C0027424", "name": "C0027424#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0078643", "name": "C0078643#ent", "pos": [13, 14]}}
{"token": ["DNA", "sequence", "analysis", "this", "C0079429#ent", "<e1>", "as", "the", "mouse", "homologue", "the", "human", "C0079429#ent", "<e1>", "encoding", "the", "p52", "subunit", "the", "C1333723#ent", "<e1>", "transcription/DNA", "repair", "factor", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333723", "name": "C1333723#ent", "pos": [19, 20]}}
{"token": ["Two", "cases", "are", "described", ":", "one", "associated", "with", "C0836924#ent", "<e1>", "and", "the", "other", "the", "first", "reported", "case", "associated", "with", "C0002892#ent", "<e2>"], "h": {"id": "C0836924", "name": "C0836924#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002892", "name": "C0002892#ent", "pos": [19, 20]}}
{"token": ["The", "patient", "received", "C0032950#ent", "<e1>", "for", "rheumatoid", "arthritis", "antibiotics", "for", "his", "fever", "and", "C0032285#ent", "<e2>", "in", "another", "hospital", ",", "but", "the", "response", "to", "the", "therapy", "was", "poor", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [13, 14]}}
{"token": ["C0010206#ent", "<e1>", "and", "homologous", "compounds", "are", "the", "most", "widely", "used", "C0009117#ent", "<e2>", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009117", "name": "C0009117#ent", "pos": [10, 11]}}
{"token": ["The", "symptoms", "of", "seasonal", "allergic", "rhinitis", "be", "alleviated", "by", "the", "use", "of", "an", "C0019592#ent", "<e1>", "and", "a", "C1306789#ent", "<e2>", "."], "h": {"id": "C0019592", "name": "C0019592#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1306789", "name": "C1306789#ent", "pos": [17, 18]}}
{"token": ["C0019592#ent", "<e1>", "use", "was", "associated", "with", "of", "C1306789#ent", "<e2>", "or", "topical", "nasal", "products", "in", "about", "one-third", "of", "patients", "."], "h": {"id": "C0019592", "name": "C0019592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1306789", "name": "C1306789#ent", "pos": [7, 8]}}
{"token": ["C1335796#ent", "<e1>", "expression", "correlated", "with", "C1704884#ent", "<e2>", "expression", "in", "that", "it", "was", "higher", "in", "visceral", "afferents", "cutaneous", "afferents", "(", "69", "%", "and", "51", "%", ",", "respectively", ")", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704884", "name": "C1704884#ent", "pos": [5, 6]}}
{"token": ["D-2", "receptor", "responses", "were", "also", "elicited", "with", "quinpirole", "or", "bromocriptine", ",", "C0162757#ent", "<e1>", "in", "the", "absence", "of", "C0080138#ent", "<e2>"], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0080138", "name": "C0080138#ent", "pos": [17, 18]}}
{"token": ["The", "C3888243#ent", "<e1>", "the", "expression", "of", "C1538622#ent", "<e2>", "in", "C2C12", "cells", "follows", "that", "of", "myogenin", "and", "precedes", "that", "of", "myosin", "heavy", "chain"], "h": {"id": "C3888243", "name": "C3888243#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538622", "name": "C1538622#ent", "pos": [6, 7]}}
{"token": ["After", "spontaneous", "resolution", "of", "the", "C0267537#ent", "<e1>", ",", "further", "chemotherapy", "has", "been", "given", "without", "recurrent", "C0243026#ent", "<e2>", "."], "h": {"id": "C0267537", "name": "C0267537#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [15, 16]}}
{"token": ["These", "C0035064#ent", "<e1>", "also", "activate", "protein", "kinase", "C", "C3539645#ent", "<e2>", ")", "in", "these", "cells", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [8, 9]}}
{"token": ["Hemipituitary", "glands", "prooestrous", "rats", "were", "incubated", "with", "C0035064#ent", "<e1>", "known", "to", "affect", "C3539645#ent", "<e2>", "and", "with", "or", "without", "LHRH", ",", "during", "which", "time", "the", "secretion", "of", "gonadotrophins", "was", "measured", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [12, 13]}}
{"token": ["Treatment", "of", "neutrophils", "with", "C0035064#ent", "<e1>", "that", "selectively", "activate", "C3539645#ent", "<e2>", "[", "4beta-phorbol", "12-myristate", "13-acetate", "PMA", ")", "]", "or", "cellular", "Ca(2", "+", ")", "(", "ionophore", "A23187", ")", "also", "triggered", "dephosphorylation", "of", "cofilin", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [9, 10]}}
{"token": ["Inhibition", "of", "C1423043#ent", "<e1>", "impairs", "spindle", "and", "kinetochore", "accumulation", "of", "C1422002#ent", "<e2>", "and", "spindle", "formation", "mitosis", ",", "suggesting", "that", "C1422002#ent", "<e2>", "association", "with", "the", "spindle", "microtubule", "kinetochore", "may", "be", "dependent", "on", "phosphorylation", "by", "C1423043#ent", "<e1>", "."], "h": {"id": "C1423043", "name": "C1423043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422002", "name": "C1422002#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "report", "that", "C1423043#ent", "<e1>", "interacts", "with", "the", "spindle-associated", "protein", "C1422002#ent", "<e2>", "both", "in", "vitro", "in", "vivo"], "h": {"id": "C1423043", "name": "C1423043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422002", "name": "C1422002#ent", "pos": [12, 13]}}
{"token": ["This", "finding", "suggests", "that", "C0035339#ent", "<e1>", "involved", "in", "the", "visual", "process", "probably", "directly", "involved", "in", "C1419621#ent", "<e2>", "lipofuscin", "fluorophore", "formation", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419621", "name": "C1419621#ent", "pos": [15, 16]}}
{"token": ["Analysis", "of", "IRBP-supplemented", "Ringer's", "solution", "incubated", "in", "the", "RPE-eyecup", "showed", "11-cis-retinal", "to", "be", "virtually", "the", "only", "C0035339#ent", "<e1>", "withdrawn", "from", "the", "C1419621#ent", "<e2>", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419621", "name": "C1419621#ent", "pos": [21, 22]}}
{"token": ["Plasminogen", "belongs", "to", "the", "C0032143#ent", "<e1>", "cell", "signaling", "proteins", "has", "recently", "been", "identified", "to", "bind", "to", "pathological", "C4082486#ent", "<e2>", ",", "but", "not", "to", "its", "normal", "conformer", "PrPC", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [17, 18]}}
{"token": ["Thus", "the", "lysine-binding", "site", "of", "kringle", "2", "is", "unique", "to", "C0032143#ent", "<e1>", "appears", "to", "mediate", "the", "specific", "stimulation", "of", "plasminogen", "activation", "the", "C4082486#ent", "<e2>"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [22, 23]}}
{"token": ["Considering", "the", "subjective", "assessment", "side-effects", "and", "duration", "of", ",", "as", "well", "as", "objective", "parameters", ",", "C3540045#ent", "<e1>", "oxymetazoline", "and", "C0078643#ent", "<e2>", ")", "are", "first", "choice", "in", "treatment", "of", "the", "common", "cold", "."], "h": {"id": "C3540045", "name": "C3540045#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0078643", "name": "C0078643#ent", "pos": [19, 20]}}
{"token": ["One", "case", "diagnosed", "as", "C0017361#ent", "<e1>", "dystrophic", "by", "electron", "microscopy", "C1705457#ent", "<e2>", ")", "followed", "a", "benign", "course", "with", "little", "scaring", "and", "was", "reclassified", "clinically", "and", "after", "reviewing", "the", "C1705457#ent", "<e2>", "as", "dominant", "dystrophic", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705457", "name": "C1705457#ent", "pos": [10, 11]}}
{"token": ["In", "other", "pituitary", "tumors", "both", "functional", "and", "nonfunctional", ",", "11", "C0044707#ent", "<e1>", "expression", "was", "variable", "in", "terms", "of", "C0022173#ent", "<e2>", "mRNA", "and", "intensity", "of", "protein", "staining"], "h": {"id": "C0044707", "name": "C0044707#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [18, 19]}}
{"token": ["Host-derived", "C0003205#ent", "<e1>", "an", "important", "source", "of", "sequences", "for", "designing", "C4084937#ent", "<e2>", "AMPs", ")", "."], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4084937", "name": "C4084937#ent", "pos": [10, 11]}}
{"token": ["We", "have", "determined", "the", "genome", "sequences", "two", "closely", "related", "lytic", "bacteriophages", "SP6", "and", "C3272787#ent", "<e1>", "-", "5", ",", "which", "infect", "Salmonella", "typhimurium", "LT2", "Escherichia", "coli", "serotypes", "K1", "C3810570#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C3272787", "name": "C3272787#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3810570", "name": "C3810570#ent", "pos": [27, 28]}}
{"token": ["The", "aqueous", "and", "50", "%", "ethanolic", "extracts", "of", "C0772125#ent", "<e1>", "Mosla", "chinensis", "Salvia", "officinalis", "Cinnamomum", "cassia", "and", "a", "C0007404#ent", "<e2>", "Camellia", "sinensis", "strong", "inhibitory", "effects", "on", "collagenolytic", "activity"], "h": {"id": "C0772125", "name": "C0772125#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007404", "name": "C0007404#ent", "pos": [18, 19]}}
{"token": ["Significant", "amounts", "of", "NFkappaB", "and", "C1417701#ent", "<e1>", "were", "found", "to", "be", "associated", "with", "C1332102#ent", "<e2>", "when", "the", "nuclear", "extract", "from", "the", "left", "ventricle", "immunoprecipitated", "with", "C1332102#ent", "<e2>", "."], "h": {"id": "C1417701", "name": "C1417701#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332102", "name": "C1332102#ent", "pos": [13, 14]}}
{"token": ["C0038013#ent", "<e1>", "RA", ")", "is", "a", "chronic", ",", "generally", "progressive", "C0004364#ent", "<e2>", "causes", "functional", "disability", "significant", "pain", "joint", "destruction", "and", "leads", "to", "premature", "mortality"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [10, 11]}}
{"token": ["The", "production", "of", "C1417388#ent", "<e1>", "provides", "a", "potential", "novel", "target", "for", "C0041296#ent", "<e2>", "treatment", "."], "h": {"id": "C1417388", "name": "C1417388#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [11, 12]}}
{"token": ["C0011777#ent", "<e1>", "also", "prevented", "transforming", "growth", "down-regulation", "of", "C1413930#ent", "<e2>", "mRNA", "levels", "and", "production", "by", "dermal", "fibroblasts"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413930", "name": "C1413930#ent", "pos": [8, 9]}}
{"token": ["C0011777#ent", "<e1>", "increased", "C1413930#ent", "<e2>", "production", ",", "maximally", "4.8-fold", ",", "and", "C1413930#ent", "<e2>", "mRNA", "levels", "up", "to", "2.3-fold", ",", "but", "had", "no", "effect", "biglycan", "production", "or", "mRNA", "levels"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413930", "name": "C1413930#ent", "pos": [3, 4]}}
{"token": ["Four", "tarsorrhaphy", "sutures", "are", "placed", "through", "the", "lower", "eyelid", "brow", "following", "C0005745#ent", "<e1>", "a", "system", "designed", "for", "patients", "with", "external", "ophthalmoplegia", "third", "nerve", "paralysis", "and", "C0026896#ent", "<e2>"], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [25, 26]}}
{"token": ["Among", "the", "agents", "tested", "were", "trichostatin", "A", "a", "C1512474#ent", "<e1>", "MG-132", ",", "a", "proteosome", "inhibitor", "the", "genotoxic", "agents", "C0020402#ent", "<e2>", ",", "aphidicolin", ",", "etoposide", "and", "camptothecin", ",", "and", "tyrphostin-1", ",", "an", "epidermal", "growth", "factor", "receptor", "inhibitor"], "h": {"id": "C1512474", "name": "C1512474#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [18, 19]}}
{"token": ["C0029883#ent", "<e1>", "is", "primarily", "C0025517#ent", "<e2>", "by", "the", "hepatic", "cytochrome", "P450", "enzyme", "system", "CYP2C19", "and", "3A4", ")", "."], "h": {"id": "C0029883", "name": "C0029883#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}}
{"token": ["It", "significantly", "inhibited", "gastric", "ulceration", "induced", "by", "C0001975#ent", "<e1>", "and", "aspirin", ",", "as", "well", "as", "C0010648#ent", "<e2>", "and", "histamine", "induced", "duodenal", "ulcers", "rats", "and", "guinea", "pigs", "respectively", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010648", "name": "C0010648#ent", "pos": [15, 16]}}
{"token": ["The", "C0085387#ent", "<e1>", "indomethacin", "or", "C0593802#ent", "<e2>", "N(G)-nitro-L-arginine", "did", "not", "alter", "the", "effect", "of", "bradykinin", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0593802", "name": "C0593802#ent", "pos": [5, 6]}}
{"token": ["Thus", ",", "droperidol", ",", "a", "safe", "butyrophenone", "neuroleptic", "appears", "to", "be", "a", "C0013227#ent", "<e1>", "of", "choice", "for", "rapid", "and", "reliable", "control", "of", "C0085631#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085631", "name": "C0085631#ent", "pos": [22, 23]}}
{"token": ["This", "inhibitory", "effect", "of", "C0771004#ent", "<e1>", "was", "not", "seen", "in", "C0027947#ent", "<e2>", "rats", "and", "ONO-5046-treated", "rats", "."], "h": {"id": "C0771004", "name": "C0771004#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "strawberry", "fractions", "inhibited", "NFAT", "activation", ",", "but", "did", "not", "inhibit", "the", "activation", "of", "AP-1", ",", "C2986464#ent", "<e1>", "or", "the", "PI-3K/Akt-p70(S6", "K", ")", "and", "C0752312#ent", "<e2>"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [26, 27]}}
{"token": ["C0041296#ent", "<e1>", "were", "demonstrated", "to", "apply", "in", "a", "C0027947#ent", "<e2>", "rat", "model", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [8, 9]}}
{"token": ["C0041296#ent", "<e1>", "should", "be", "considered", "as", "one", "cause", "of", "hepatosplenic", "abscesses", "prolonged", "C0027947#ent", "<e2>", ",", "especially", "in", "countries", "where", "the", "disease", "is", "endemic", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [12, 13]}}
{"token": ["We", "present", "a", "case", "of", "a", "66-year-old", "woman", "with", "bone", "marrow", "necrosis", "acute", "acalculous", "cholecystitis", "C3890007#ent", "<e1>", ")", ",", "focal", "liver", "necrosis", "subtle", "patchy", "C0037998#ent", "<e2>", "and", "bilateral", "adrenal", "infarction"], "h": {"id": "C3890007", "name": "C3890007#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0037998", "name": "C0037998#ent", "pos": [24, 25]}}
{"token": ["Parenteral", "nutrition", "C3541307#ent", "<e1>", ")", "solution", "contains", "various", "concentrations", "of", "dextrose", ",", "C3539947#ent", "<e2>", "lipids", ",", "vitamins", ",", "electrolytes", ",", "and", "trace", "elements"], "h": {"id": "C3541307", "name": "C3541307#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}}
{"token": ["Refractive", "indices", "single", "nutrient", "components", "and", "C3541307#ent", "<e1>", "solutions", "consisting", "of", "various", "concentrations", "of", "dextrose", ",", "C3539947#ent", "<e2>", "electrolytes", ",", "and", "lipids", "were", "measured", "."], "h": {"id": "C3541307", "name": "C3541307#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [16, 17]}}
{"token": ["A", "simple", "synthetic", "route", "the", "preparation", "of", "C1257880#ent", "<e1>", "5-aminosalicylic", "acid", "5-ASA", ")", "was", "exploited", "and", "prepared", "C0762580#ent", "<e2>", "(", "5-ASA-Gly", ")", "in", "good", "yield", "."], "h": {"id": "C1257880", "name": "C1257880#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0762580", "name": "C0762580#ent", "pos": [17, 18]}}
{"token": ["We", "studied", "the", "molecular", "mechanism", "a", "case", "of", "C2678478#ent", "<e1>", "showed", "no", "response", "a", "C0003195#ent", "<e2>"], "h": {"id": "C2678478", "name": "C2678478#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [14, 15]}}
{"token": ["Congenital", "insensitivity", "to", "pain", "with", "anhidrosis", "(", "C0020074#ent", "<e1>", ")", ",", "also", "called", "hereditary", "sensory", "autonomic", "neuropathy", "type", "IV", "C0020074#ent", "<e1>", ",", "is", "caused", "by", "mutations", "of", "the", "NTRK1", "gene", "coding", "the", "neurotrophic", "tyrosine", "kinase", "receptor", "type", "1"], "h": {"id": "C0020074", "name": "C0020074#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020074", "name": "C0020074#ent", "pos": [7, 8]}}
{"token": ["Hereditary", "sensory", "C0020074#ent", "<e1>", "HSAN", "IV", "or", "congenital", "insensitivity", "to", "pain", "with", "anhidrosis", "(", "C0020074#ent", "<e1>", ")", "is", "an", "autosomal-recessive", "disorder", "the", "neurotrophin", "signal", "transduction", "pathway"], "h": {"id": "C0020074", "name": "C0020074#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020074", "name": "C0020074#ent", "pos": [2, 3]}}
{"token": ["Fifty", "patients", "with", "C0017612#ent", "<e1>", "treated", "twice", "daily", "for", "one", "year", "with", "topical", "0.5", "%", "C0006388#ent", "<e2>", ",", "1", "%", "C0006388#ent", "<e2>", ",", "or", "0.5", "%", "timolol", "."], "h": {"id": "C0017612", "name": "C0017612#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0006388", "name": "C0006388#ent", "pos": [15, 16]}}
{"token": ["Treatment", "of", "rats", "with", "PTK", "blocker", "(", "C0388640#ent", "<e1>", ")", "or", "MAPK", "blocker", "(", "C0528985#ent", "<e2>", ")", "before", "burn", "injury", "complete", "inhibition", "of", "the", "respective", "kinase", "activation"], "h": {"id": "C0388640", "name": "C0388640#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0528985", "name": "C0528985#ent", "pos": [14, 15]}}
{"token": ["Varicella", "zoster", "virus", "antibodies", "were", "detected", "in", "all", "five", "C0008049#ent", "<e1>", "and", "seven", "C0019360#ent", "<e2>", "patients", "."], "h": {"id": "C0008049", "name": "C0008049#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0019360", "name": "C0019360#ent", "pos": [13, 14]}}
{"token": ["Chemiluminescence", "(", "CL", ")", "analysis", "of", "monocytes", "and", "C0064833#ent", "<e1>", "PMNs", ")", "was", "performed", "on", "13", "patients", "with", "Crohn's", "disease", "C2348923#ent", "<e2>", ")", "and", "10", "healthy", "volunteers"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2348923", "name": "C2348923#ent", "pos": [20, 21]}}
{"token": ["This", "report", "describes", "MLO-parasitized", "vitreous", "lymphocytes", ",", "monocytes", ",", "and", "C0064833#ent", "<e1>", "three", "patients", "with", "C2348923#ent", "<e2>", "who", "had", "chronic", "uveitis"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2348923", "name": "C2348923#ent", "pos": [15, 16]}}
{"token": ["C3668957#ent", "<e1>", "and", "other", "C0004364#ent", "<e2>", "as", "systemic", "lupus", "erythematosus", "polymyositis", "are", "rare", "in", "Africa", "."], "h": {"id": "C3668957", "name": "C3668957#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [4, 5]}}
{"token": ["Psoriasis", "is", "a", "common", "C3875321#ent", "<e1>", "by", "genetic", "and", "environmental", "factors", "including", "bacterial", "and", "C0042769#ent", "<e2>"], "h": {"id": "C3875321", "name": "C3875321#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [14, 15]}}
{"token": ["C1332428#ent", "<e1>", "stimulated", "phosphorylation", "of", "endogenous", "C1416962#ent", "<e2>", "and", "5", ",", "formation", "of", "complexes", "with", "Smad4", "and", "induced", "the", "promoter", "for", "the", "homeobox", "gene", "Tlx2", "."], "h": {"id": "C1332428", "name": "C1332428#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416962", "name": "C1416962#ent", "pos": [6, 7]}}
{"token": ["The", "heterozygous", "nonsense", "or", "missense", "mutations", "identified", "in", "the", "patients", "with", "C2936739#ent", "<e1>", "C1705459#ent", "<e2>", "and", "a", "sporadic", "C1705459#ent", "<e2>", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705459", "name": "C1705459#ent", "pos": [13, 14]}}
{"token": ["The", "purpose", "of", "the", "work", "was", "an", "explanation", ",", "what", "was", "the", "influence", "of", "many", "years", "of", "hemodialysis", "therapy", "C0016424#ent", "<e1>", "secretion", "in", "men", "with", "C0022661#ent", "<e2>", "CRF", ")", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [25, 26]}}
{"token": ["After", "LHRH", "administration", ",", "peak", "levels", "LH", "and", "C0016424#ent", "<e1>", "were", "not", "different", "in", "C0022661#ent", "<e2>", "and", "control", "children", "however", ",", "the", "absolute", "differences", "from", "basal", "to", "peak", "values", "were", "lower", "in", "C0022661#ent", "<e2>", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [14, 15]}}
{"token": ["This", "C1432368#ent", "<e1>", "dsPTPase", ")", "and", "other", "members", "of", "the", "C1335554#ent", "<e2>", "PTPases", ")", "have", "only", "recently", "joined", "the", "protease", "and", "kinase", "enzyme", "families", "in", "drug", "discovery", "."], "h": {"id": "C1432368", "name": "C1432368#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [10, 11]}}
{"token": ["The", "findings", "of", "this", "pilot", "study", "that", "Australian", "nurses", "experience", "sleepiness", "and", "related", "C1457887#ent", "<e1>", "work", "and", "during", "their", "C4085339#ent", "<e2>", "home", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4085339", "name": "C4085339#ent", "pos": [19, 20]}}
{"token": ["However", ",", "in", "contrast", "to", "previous", "reports", "with", "C1420357#ent", "<e1>", ",", "sphingosine-1-phosphate", "does", "not", "inhibit", "the", "C0031607#ent", "<e2>", "activity", "in", "cell", "homogenates"], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031607", "name": "C0031607#ent", "pos": [16, 17]}}
{"token": ["In", "this", "report", "we", "show", "that", "prior", "to", "induction", "CBF1/RBP-Jkappa", "interacts", "with", "a", "corepressor", "complex", "SMRT", "(", "silencing", "mediator", "of", "C0035339#ent", "<e1>", "and", "thyroid", "hormone", "receptors", "and", "the", "C0019643#ent", "<e2>", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [28, 29]}}
{"token": ["Gene", "expression", "profiling", "gene", "family", "cDNA", "arrays", "numerous", "C0017337#ent", "<e1>", "that", "are", "differentially", "expressed", "in", "C1335643#ent", "<e2>", "the", "resistant", "subclones", "and", "therefore", "are", "potentially", "involved", "in", "the", "definition", "of", "sensitivity", "to", "apoptotic", "stimuli"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335643", "name": "C1335643#ent", "pos": [15, 16]}}
{"token": ["We", "present", "a", "patient", "with", "C1701938#ent", "<e1>", "achieved", "substantial", "clinical", "improvement", "the", "C1516869#ent", "<e2>"], "h": {"id": "C1701938", "name": "C1701938#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [12, 13]}}
{"token": ["Limited", "cutaneous", "systemic", "sclerosis", "lSSc", ")", "or", "C0206138#ent", "<e1>", "sometimes", "complicated", "by", "primary", "biliary", "cirrhosis", "C0008312#ent", "<e2>", ")", "."], "h": {"id": "C0206138", "name": "C0206138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [15, 16]}}
{"token": ["Limited", "C0206138#ent", "<e1>", "lSSc", ")", "or", "CREST", "syndrome", "sometimes", "complicated", "by", "primary", "biliary", "cirrhosis", "C0008312#ent", "<e2>", ")", "."], "h": {"id": "C0206138", "name": "C0206138#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [14, 15]}}
{"token": ["Limited", "cutaneous", "systemic", "sclerosis", "C0206138#ent", "<e1>", ")", "or", "CREST", "syndrome", "sometimes", "complicated", "by", "C0008312#ent", "<e2>", "PBC", ")", "."], "h": {"id": "C0206138", "name": "C0206138#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [13, 14]}}
{"token": ["A", "68", "year-old", "woman", "was", "diagnosed", "as", "C0206138#ent", "<e1>", "accompanied", "by", "Hashimoto's", "thyroiditis", "C0008312#ent", "<e2>"], "h": {"id": "C0206138", "name": "C0206138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [13, 14]}}
{"token": ["In", "24", "cases", "the", "indication", "for", "vitrectomy", "was", "an", "intermediary", "uveitis", "a", "C0394016#ent", "<e1>", "4", "and", "a", "C0029077#ent", "<e2>", "6", "cases", "as", "well", "as", "suppurative", "endophthalmitis", "7", "patients", "."], "h": {"id": "C0394016", "name": "C0394016#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029077", "name": "C0029077#ent", "pos": [17, 18]}}
{"token": ["Less", "than", "10", "%", "of", "all", "subjects", "with", "the", "C0027404#ent", "<e1>", "a", "daytime", "sleep", "in", "the", "normal", "range", "on", "C0011812#ent", "<e2>", "and", "no", "subject", "on", "clomipramine", "reported", "complete", "control", "of", "cataplexy", "."], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0011812", "name": "C0011812#ent", "pos": [19, 20]}}
{"token": ["Subjective", "evaluation", "of", "the", "effect", "of", "treatment", "of", "C0027404#ent", "<e1>", "EDS", ")", "with", "C0011812#ent", "<e2>", "and", "of", "cataplexy", "with", "clomipramine", "was", "made", "in", "124", "subjects", "with", "the", "narcoleptic", "syndrome"], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0011812", "name": "C0011812#ent", "pos": [13, 14]}}
{"token": ["Yet", "the", "infrequency", "of", "mucocutaneous", "disease", "compared", "with", "C0029166#ent", "<e1>", "and", "the", "difficulty", "of", "C1875400#ent", "<e2>", "parasites", "from", "mucocutaneous", "lesions", "have", "restricted", "the", "study", "of", "the", "organisms", "involved", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [14, 15]}}
{"token": ["C2607929#ent", "<e1>", "an", "autosomal", "dominant", "neoplasia", "syndrome", "by", "spotty", "skin", "pigmentation", "C0027152#ent", "<e2>", ",", "endocrine", "tumors", "and", "schwannomas", "."], "h": {"id": "C2607929", "name": "C2607929#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027152", "name": "C0027152#ent", "pos": [11, 12]}}
{"token": ["Deficient", "intake", "of", "C3541396#ent", "<e1>", "from", "the", "diet", "upregulates", "both", "C1415358#ent", "<e2>", "(", "UG", ")", "and", "inducible", "nitric", "oxide", "synthase", "iNOS", ")", "expression", "in", "rats", "."], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415358", "name": "C1415358#ent", "pos": [10, 11]}}
{"token": ["There", "exists", "a", "considerable", "clinical", "and", "biochemical", "heterogeneity", "among", "the", "C0206157#ent", "<e1>", "due", "to", "disturbances", "in", "the", "C0171406#ent", "<e2>"], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [17, 18]}}
{"token": ["Also", ",", "as", "indices", "of", "renal", "function", "C1417593#ent", "<e1>", "in", "urine", "together", "with", "C1412709#ent", "<e2>", "examined", "."], "h": {"id": "C1417593", "name": "C1417593#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412709", "name": "C1412709#ent", "pos": [13, 14]}}
{"token": ["Urinary", "citrate", "albumin", ",", "C1417593#ent", "<e1>", ",", "ALP", "and", "C1412709#ent", "<e2>", "were", "measured", "and", "creatinine", "clearance", "was", "calculated", "."], "h": {"id": "C1417593", "name": "C1417593#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412709", "name": "C1412709#ent", "pos": [9, 10]}}
{"token": ["We", "demonstrate", "here", "that", "both", "alpha1-AdrR", "stimulation", "and", "C0034678#ent", "<e1>", "can", "also", "activate", "the", "C0380051#ent", "<e2>", "JNK", ")", "in", "cardiomyocytes", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [14, 15]}}
{"token": ["Protein", "kinases", "the", "transfer", "of", "the", "gamma-phosphate", "group", "from", "C2744579#ent", "<e1>", "to", "a", "serine", ",", "threonine", "or", "tyrosine", "residue", "an", "C1327771#ent", "<e2>"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1327771", "name": "C1327771#ent", "pos": [20, 21]}}
{"token": ["The", "amino", "acid", "sequence", "44.3", "%", "and", "43.7", "%", "identity", "to", "the", "Escherichia", "coli", "lysyl-tRNA", "synthetases", "encoded", "by", "C0034494#ent", "<e1>", "and", "lysU.", "Only", "one", "C0024376#ent", "<e2>", "gene", "was", "found", "in", "M.", "hominis", "."], "h": {"id": "C0034494", "name": "C0034494#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0024376", "name": "C0024376#ent", "pos": [24, 25]}}
{"token": ["A", "DNA", "region", "C0034494#ent", "<e1>", ",", "the", "gene", "encoding", "the", "C0024376#ent", "<e2>", "was", "cloned", "from", "the", "extreme", "thermophile", "prokaryote", "Thermus", "thermophilus", "and", "sequenced", "."], "h": {"id": "C0034494", "name": "C0034494#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024376", "name": "C0024376#ent", "pos": [10, 11]}}
{"token": ["C0268120#ent", "<e1>", "an", "autosomal", "recessive", "purine", "enzyme", "defect", "that", "causes", "C0451641#ent", "<e2>", "and", ",", "in", "severe", "cases", ",", "renal", "failure"], "h": {"id": "C0268120", "name": "C0268120#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [10, 11]}}
{"token": ["Within", "the", "nucleus", ",", "FADD", "interacted", "with", "the", "methyl-CpG", "binding", "domain", "protein", "4", "C0766421#ent", "<e1>", ")", ",", "which", "excises", "thymine", "from", "C1704693#ent", "<e2>", "mismatches", "in", "methylated", "regions", "chromatin", "."], "h": {"id": "C0766421", "name": "C0766421#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704693", "name": "C1704693#ent", "pos": [21, 22]}}
{"token": ["CREB-binding", "protein", "C1705776#ent", "<e1>", ")", "and", "its", "homologue", "C1705458#ent", "<e2>", "are", "transcriptional", "co-activators", "of", "various", "sequence-specific", "transcription", "factors", "are", "involved", "in", "a", "wide", "array", "of", "cellular", "activities", "such", "as", "DNA", "repair", "cell", "growth", "differentiation", "and", "apoptosis", "."], "h": {"id": "C1705776", "name": "C1705776#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705458", "name": "C1705458#ent", "pos": [8, 9]}}
{"token": ["Combined", "therapy", "C0028066#ent", "<e1>", "and", "C0025859#ent", "<e2>", "contrary", "to", "monotherapy", "with", "C0028066#ent", "<e1>", "alone", ",", "results", "in", "the", "regression", "of", "left", "ventricular", "mass", "the", "improvement", "of", "left", "ventricular", "diastolic", "function"], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [2, 3]}}
{"token": ["In", "this", "acute", "exercise", "study", "patients", "with", "stable", "exertional", "angina", "C0025859#ent", "<e1>", "added", "to", "C0028066#ent", "<e2>", "markedly", "improved", "exercise", "capacity", "by", "preventing", "the", "increase", "in", "heart", "rate", "with", "C0028066#ent", "<e2>", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [14, 15]}}
{"token": ["We", "studied", "the", "antioxidant", "effect", "four", "beta-adrenergic", "blocking", "agents", "pindolol", ",", "propranolol", ",", "atenolol", "and", "C0025859#ent", "<e1>", ")", "and", "of", "one", "calcium", "channel", "antagonist", "C0028066#ent", "<e2>", ")", ",", "on", "the", "plasma", "oxidative", "damage", "induced", "by", "copper", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [24, 25]}}
{"token": ["Thus", ",", "we", "investigated", "the", "prevalence", "of", "vasopressin", "deficiency", "hypotensive", "solid", "organ", "donors", "without", "clinical", "evidence", "C0011848#ent", "<e1>", "we", "also", "investigated", "the", "vasopressor", "effect", "vasopressin", "replacement", "in", "C0003364#ent", "<e2>"], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [27, 28]}}
{"token": ["To", "test", "the", "efficacy", "of", "C0001911#ent", "<e1>", "against", "the", "C0040954#ent", "<e2>", "school-based", "deworming", "in", "the", "south-western", "Cape", ",", "South", "Africa"], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0040954", "name": "C0040954#ent", "pos": [9, 10]}}
{"token": ["One", "such", "sequence", "was", "a", "previously", "unreported", "gene", "with", "high", "homology", "to", "the", "meningococcal", "immunoglobulin", "A", "IgA", ")", "C1335528#ent", "<e1>", "which", "is", "distinct", "from", "the", "previously", "described", "H.", "influenzae", "C0030946#ent", "<e2>"], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [29, 30]}}
{"token": ["Studies", "with", "HSV-1", "strains", "harbour", "mutations", "in", "the", "C1335528#ent", "<e1>", "demonstrated", "that", "the", "C0030946#ent", "<e2>", "is", "essential", "for", "DNA", "packaging", "virus", "maturation"], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [13, 14]}}
{"token": ["C0295734#ent", "<e1>", "and", "specific", "isoforms", "of", "C1424731#ent", "<e2>", "and", "-2", "are", "nuclear", "membrane", "proteins", "are", "binding", "partners", "in", "multi-protein", "complexes", "the", "nuclear", "envelope"], "h": {"id": "C0295734", "name": "C0295734#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424731", "name": "C1424731#ent", "pos": [6, 7]}}
{"token": ["This", "work", "demonstrates", "the", "roles", "of", "NS", "in", "establishing", "early", "embryogenesis", "and", "delaying", "C1423721#ent", "<e1>", "MEFs", "and", "reveals", "a", "mechanism", "of", "a", "NS-regulated", "degradation", "C1705002#ent", "<e2>", "."], "h": {"id": "C1423721", "name": "C1423721#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705002", "name": "C1705002#ent", "pos": [24, 25]}}
{"token": ["Taken", "together", ",", "we", "identified", "a", "novel", "motif", "in", "the", "Gli/Ci", "family", "of", "C0086376#ent", "<e1>", "that", "is", "essential", "both", "for", "protein-protein", "interaction", "C3273645#ent", "<e2>", "and", "for", "functional", "repression", "of", "GLI1", "by", "C3273645#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3273645", "name": "C3273645#ent", "pos": [22, 23]}}
{"token": ["C0086376#ent", "<e1>", "such", "as", "Fused", ",", "Suppressor", "of", "fused", "C3273645#ent", "<e2>", ")", ",", "Costal-2", ",", "and", "protein", "kinase", "A", "essential", "for", "regulation", "of", "Gli/Ci", "processing", ",", "activity", ",", "and", "localization", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273645", "name": "C3273645#ent", "pos": [9, 10]}}
{"token": ["In", "c-Jun", "Re", "cells", ",", "TG", "induced", "the", "expression", "of", "C2826585#ent", "<e1>", ",", "also", "known", "as", "the", "Down", "syndrome", "critical", "region", "1", "C2826583#ent", "<e2>", ")", ",", "which", "is", "known", "to", "block", "calcineurin", "activity", "."], "h": {"id": "C2826585", "name": "C2826585#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2826583", "name": "C2826583#ent", "pos": [22, 23]}}
{"token": ["A", "host", "protein", "C0950301#ent", "<e1>", "can", "bind", "ectopic", "cytoplasmic", "DNA", "block", "viral", "DNA", "replication", "whereas", "C0042214#ent", "<e2>", "in", "turn", "counteracts", "this", "inhibition", "with", "a", "virus-encoded", "serine", "threonine", "kinase", "inactivates", "C0950301#ent", "<e1>", "."], "h": {"id": "C0042214", "name": "C0042214#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0950301", "name": "C0950301#ent", "pos": [3, 4]}}
{"token": ["In", "patients", "with", "gastric", "cancer", "with", "esophageal", "and/or", "C0017145#ent", "<e1>", "it", "is", "recommended", "that", "DSRS", "with", "C3273505#ent", "<e2>", "be", "performed", "after", "a", "reconstruction", "using", "the", "Billroth", "I", "method"], "h": {"id": "C0017145", "name": "C0017145#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273505", "name": "C3273505#ent", "pos": [16, 17]}}
{"token": ["Sequencing", "of", "16S", "ribosomal", "C0011522#ent", "<e1>", "selected", "on", "the", "basis", "of", "DGGE", "C1456390#ent", "<e2>", "allowed", "the", "identification", "of", "strains", "not", "detected", "by", "cultural", "means"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1456390", "name": "C1456390#ent", "pos": [12, 13]}}
{"token": ["The", "applications", "discussed", "in", "this", "review", "are", ":", "C0878544#ent", "<e1>", "cardiomyopathies", ",", "arrhythmogenic", "right", "ventricular", "dysplasia", "myocarditis", ";", "pericardial", "diseases", "especially", "C0031048#ent", "<e2>", "cardiac", "and", "paracardiac", "masses", ";", "and", "valvular", "heart", "disease"], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031048", "name": "C0031048#ent", "pos": [21, 22]}}
{"token": ["Restrictive", "cardiomyopathy", "a", "clinical", "entity", "primary", "or", "C0878544#ent", "<e1>", "a", "picture", "that", "closely", "simulates", "that", "of", "C0031048#ent", "<e2>"], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031048", "name": "C0031048#ent", "pos": [16, 17]}}
{"token": ["The", "applications", "discussed", "in", "this", "review", "are", ":", "myocardial", "diseases", "C0878544#ent", "<e1>", ",", "arrhythmogenic", "right", "ventricular", "dysplasia", "myocarditis", ";", "pericardial", "diseases", "especially", "C0031048#ent", "<e2>", "cardiac", "and", "paracardiac", "masses", ";", "and", "valvular", "heart", "disease"], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031048", "name": "C0031048#ent", "pos": [22, 23]}}
{"token": ["betaxolol", ",", "yohimbine", ",", "WB-4101", ",", "C0032912#ent", "<e1>", ",", "mianserine", ";", "agonists", "--", "isoprenaline", "approximately", "equal", "to", "C0015840#ent", "<e2>", ">", "salbutamol", ">", ">", "clonidine", ",", "phenylephrine", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015840", "name": "C0015840#ent", "pos": [17, 18]}}
{"token": ["Generally", ",", "COX", "1", "constitutively", "expressed", "in", "most", "tissues", ",", "where", "it", "maintains", "physiological", "processes", "inducible", "C1565830#ent", "<e1>", "considered", "a", "pro-inflammatory", "C0014442#ent", "<e2>", "and", "a", "chief", "target", "for", "the", "treatment", "of", "inflammatory", "diseases"], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["The", "inhibition", "of", "C1565830#ent", "<e1>", "was", "evaluated", "using", "intact", "bovine", "platelets", "as", "the", "C0014442#ent", "<e2>", "source", ",", "whereas", "LPS-stimulated", "human", "monocytes", "served", "as", "the", "C0014442#ent", "<e2>", "source", "for", "inducible", "COX-2", "."], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["The", "loss", "of", "C0812258#ent", "<e1>", "and", "C1414223#ent", "<e2>", "impedes", "B-cell", "differentiation", "and", "hematopoietic", "progenitor", "cells", "the", "bone", "marrow", "mice", "lacking", "C0812258#ent", "<e1>", "and", "C1414223#ent", "<e2>", "exhibit", "increased", "cell", "cycling"], "h": {"id": "C1414223", "name": "C1414223#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812258", "name": "C0812258#ent", "pos": [3, 4]}}
{"token": ["The", "effects", "of", "tricyclic", "antidepressants", "desipramine", "and", "imipramine", ",", "and", "phenothiazines", ",", "C0008286#ent", "<e1>", "and", "trifluoperazine", ",", "on", "C0008269#ent", "<e2>", "CQ-sensitive", "lines", "of", "P.", "chabaudi", "were", "examined", "in", "vivo"], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [18, 19]}}
{"token": ["The", "C0040083#ent", "<e1>", "TP", ")", "then", "hydrolyzes", "5'-DFUR", "to", "the", "C1254351#ent", "<e2>", "5-FU", "."], "h": {"id": "C0040083", "name": "C0040083#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}}
{"token": ["The", "C0856825#ent", "<e1>", "present", "is", "a", "pluri-visceral", "syndrome", "in", "which", "certain", "C0034087#ent", "<e2>", "recognised", "."], "h": {"id": "C0856825", "name": "C0856825#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034087", "name": "C0034087#ent", "pos": [11, 12]}}
{"token": ["Recent", "neurophysiological", "and", "pathological", "studies", "led", "to", "a", "reclassification", "of", "the", "diseases", "that", "underlie", "Guillain-Barr\u00e9", "syndrome", "C4083008#ent", "<e1>", ")", "into", "acute", "inflammatory", "demyelinating", "polyradiculoneuropathy", "AIDP", ")", ",", "acute", "motor", "sensory", "axonal", "neuropathy", "C0002699#ent", "<e2>", ")", "and", "acute", "motor", "axonal", "neuropathy", "AMAN", ")", "."], "h": {"id": "C4083008", "name": "C4083008#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002699", "name": "C0002699#ent", "pos": [32, 33]}}
{"token": ["During", "C0003504#ent", "<e1>", "was", "observed", "statistically", "significant", "increase", "C1417807#ent", "<e2>", "levels", "in", "all", "KTP", "."], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "VLDLR", "deficiency", "on", "C0004153#ent", "<e1>", "was", "examined", "in", "C0394006#ent", "<e2>", "an", "LDLR", "deficient", "(", "LDLR-/-", ")", "background", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [11, 12]}}
{"token": ["This", "study", "reports", "our", "experience", "with", "a", "combined", "treatment", "with", "cyclosporin", "A", "Cy", "A", "and", "cortisone", "in", "patients", "with", "C0015397#ent", "<e1>", "GO", ")", ",", "all", "of", "whom", "had", "C0029132#ent", "<e2>", "CON", ")", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [19, 20]}, "relation": "related_to", "t": {"id": "C0029132", "name": "C0029132#ent", "pos": [28, 29]}}
{"token": ["The", "results", "support", "the", "notion", "that", "the", "formation", "of", "genotoxic", "metabolites", "from", "C0020402#ent", "<e1>", "is", "mediated", "by", "a", "C0000644#ent", "<e2>"], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0000644", "name": "C0000644#ent", "pos": [18, 19]}}
{"token": ["The", "clinical", "differentiation", "multifocal", "choroiditis", "panuveitis", "(", "C1413108#ent", "<e1>", ")", "and", "the", "presumed", "C1562543#ent", "<e2>", "POHS", ")", "can", "be", "difficult", "."], "h": {"id": "C1413108", "name": "C1413108#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1562543", "name": "C1562543#ent", "pos": [13, 14]}}
{"token": ["Maize", "C1417088#ent", "<e1>", "coded", "by", "four", "genetic", "loci", "Mdh1", ",", "C4083833#ent", "<e2>", ",", "Mdh3", "and", "Mdh4", "."], "h": {"id": "C1417088", "name": "C1417088#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4083833", "name": "C4083833#ent", "pos": [10, 11]}}
{"token": ["The", "activity", "of", "C1623430#ent", "<e1>", "in", "cultured", "cells", "be", "modified", "by", "changing", "the", "level", "of", "C1413137#ent", "<e2>", ",", "an", "endogenous", "calpain", "inhibitor", "indicating", "that", "C1623430#ent", "<e1>", "is", "also", "a", "substrate", "for", "calpain", "in", "vivo"], "h": {"id": "C1413137", "name": "C1413137#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [3, 4]}}
{"token": ["Neurochemical", "binding", "studies", "suggest", "that", "C0006462#ent", "<e1>", "has", "both", "dopamine", "C0243192#ent", "<e2>", "and", "antagonist", "properties", "."], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}}
{"token": ["C0006462#ent", "<e1>", "is", "a", "serotonin", "5-HT(1A)", "receptor", "C0243192#ent", "<e2>", "licensed", "for", "the", "treatment", "of", "anxiety", "."], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [7, 8]}}
{"token": ["The", "anxiolytic", "effects", "C0006462#ent", "<e1>", "could", "be", "due", "to", "either", "DA", "C0243192#ent", "<e2>", "or", "antagonist", "effects", "."], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "unlike", "the", "case", "of", "C0041323#ent", "<e1>", "the", "rate", "of", "nephritis", "including", "glomerulitis", ",", "arteriolitis", "and", "C0027707#ent", "<e2>", "Hayashi", "used", "as", "his", "criteria", "does", "not", "seem", "to", "have", "decreased", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027707", "name": "C0027707#ent", "pos": [18, 19]}}
{"token": ["The", "inhibition", "of", "C1367657#ent", "<e1>", "up-regulation", "caused", "by", "C0035179#ent", "<e2>", "may", "reflect", "an", "action", "of", "Li", "on", "non-adrenergic", "systems", "rather", "than", "a", "general", "\"", "stabilizing", "\"", "effect", "on", "adrenoceptors", "proposed", "previously", "."], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [8, 9]}}
{"token": ["The", "sensitivity", "of", "the", "adenylate", "cyclase", "C1367657#ent", "<e1>", "improved", "by", "pre-treatment", "of", "the", "animals", "with", "C0035179#ent", "<e2>", "and", "syrosingopine", "."], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [15, 16]}}
{"token": ["Further", ",", "up-regulation", "of", "transglutaminase", "1", "C1420714#ent", "<e1>", "expression", ",", "and", "reduction", "of", "C1420715#ent", "<e2>", "levels", ",", "were", "also", "observed", "in", "NGF-treated", "cells", "in", "comparison", "to", "untreated", "cells", "."], "h": {"id": "C1420714", "name": "C1420714#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420715", "name": "C1420715#ent", "pos": [13, 14]}}
{"token": ["These", "animals", "can", "be", "grouped", "into", "EmuLMP2A(BCR+", ")", "(", "TgB", ",", "Tg6", ",", "and", "C1420714#ent", "<e1>", ")", "and", "EmuLMP2A(BCR-", ")", "(", "Tg7", "and", "C1420715#ent", "<e2>", ")", "lines", "based", "on", "B-cell", "phenotype"], "h": {"id": "C1420714", "name": "C1420714#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420715", "name": "C1420715#ent", "pos": [23, 24]}}
{"token": ["LAT1", "(", "C1442753#ent", "<e1>", ",", "one", "of", "the", "L-type", "amino", "acid", "transporters", "transports", "the", "branched", "and", "C0301713#ent", "<e2>"], "h": {"id": "C1442753", "name": "C1442753#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0301713", "name": "C0301713#ent", "pos": [16, 17]}}
{"token": ["LAT1", "(", "L-type", "amino", "acid", "transporter", "1", ",", "one", "of", "the", "C1442753#ent", "<e1>", "transports", "the", "branched", "and", "C0301713#ent", "<e2>"], "h": {"id": "C1442753", "name": "C1442753#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0301713", "name": "C0301713#ent", "pos": [17, 18]}}
{"token": ["ATP-binding", "cassette", "transporter-1", "ABCA1", ")", "is", "a", "cause", "of", "C0039292#ent", "<e1>", "which", "is", "a", "C0023817#ent", "<e2>", "plasma", "high", "density", "lipoproteins", "(", "HDL", ")", "."], "h": {"id": "C0039292", "name": "C0039292#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023817", "name": "C0023817#ent", "pos": [14, 15]}}
{"token": ["In", "the", "presence", "of", "C0020402#ent", "<e1>", ",", "which", "inactivates", "both", "the", "cellular", "and", "C0035547#ent", "<e2>", "growth", "of", "the", "mutant", "at", "31", "degrees", "was", "inhibited", "more", "than", "wild-type", "virus", "replication"], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0035547", "name": "C0035547#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "C0020402#ent", "<e1>", "and", "4-methyl-5-aminoisoquinoline", "thiosemicarbazone", "two", "inhibitors", "of", "C0035547#ent", "<e2>", "affect", "protein", "M2", "also", "inhibited", "the", "[32P]CDP", "labeling", "of", "protein", "M1"], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [3, 4]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0035547", "name": "C0035547#ent", "pos": [11, 12]}}
{"token": ["In", "guinea", "pigs", ",", "all", "C1510932#ent", "<e1>", "increased", "myometrial", "responsiveness", "to", "oxytocin", "and", "C0356622#ent", "<e2>", ",", "onapristone", "being", "approximately", "10", "times", "more", "effective", "than", "RU486", "."], "h": {"id": "C1510932", "name": "C1510932#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [13, 14]}}
{"token": ["We", "now", "report", "that", "C0525037#ent", "<e1>", "status", "of", "T-ALL", "cells", "influences", "their", "sensitivity", "to", "C0950721#ent", "<e2>", "."], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0950721", "name": "C0950721#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "UCN-01-induced", "G1", "arrest", "occur", "in", "cells", "null", "for", "p53", "and", "C0525037#ent", "<e1>", ",", "and", "that", "RB", "status", "influences", "the", "ability", "of", "C0950721#ent", "<e2>", "to", "induce", "a", "G1", "arrest"], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0950721", "name": "C0950721#ent", "pos": [24, 25]}}
{"token": ["As", "further", "support", "of", "this", "hypothesis", ",", "we", "found", "that", "suramin", "also", "blocked", "infection", "by", "C0011226#ent", "<e1>", "an", "RNA", "virus", "is", "not", "known", "to", "employ", "C1955880#ent", "<e2>", "the", "initiation", "of", "infection", "."], "h": {"id": "C0011226", "name": "C0011226#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [25, 26]}}
{"token": ["ACK1", "(", "activated", "C1449330#ent", "<e1>", "is", "a", "C1336653#ent", "<e2>", "the", "only", "tyrosine", "kinase", "to", "interact", "with", "Cdc42", "."], "h": {"id": "C1449330", "name": "C1449330#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336653", "name": "C1336653#ent", "pos": [7, 8]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "the", "AMPA/KA", "or", "NMDA-stimulated", "dephosphorylation", "of", "C1418825#ent", "<e1>", "via", "calcineurin", ",", "leading", "to", "increased", "C1418858#ent", "<e2>", "activity", "and", "dephosphorylation", "of", "GluR1", "."], "h": {"id": "C1418825", "name": "C1418825#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418858", "name": "C1418858#ent", "pos": [19, 20]}}
{"token": ["The", "clinical", "course", "C0267797#ent", "<e1>", "generally", "milder", "than", "acute", "hepatitis", "B", "with", "lower", "C0002594#ent", "<e2>", "activities", "and", "bilirubin", "level"], "h": {"id": "C0267797", "name": "C0267797#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [13, 14]}}
{"token": ["The", "patients", "were", "diagnosed", "as", "having", "severe", "hepatitis", "if", "C0267797#ent", "<e1>", "associated", "with", "serum", "bilirubin", "and", "C0002594#ent", "<e2>", "and", "if", "they", "had", "a", "prothrombin", "time", "index", "<", "50", "%", "."], "h": {"id": "C0267797", "name": "C0267797#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [16, 17]}}
{"token": ["Inhibition", "of", "PI3", "K", "activity", "decreased", "the", "proportion", "of", "cytokine-treated", "cells", "entering", "S", "phase", "was", "associated", "with", "significant", "reduction", "in", "C3273763#ent", "<e1>", "phosphorylation", "and", "activation", "of", "C1332733#ent", "<e2>", "."], "h": {"id": "C3273763", "name": "C3273763#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1332733", "name": "C1332733#ent", "pos": [26, 27]}}
{"token": ["The", "results", "establish", "that", "human", "C0032144#ent", "<e1>", "milk", "activator", ",", "and", "C0032143#ent", "<e2>", "the", "adrenals", "are", "immunologically", "distinct", "from", "human", "urokinase", "."], "h": {"id": "C0032144", "name": "C0032144#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [11, 12]}}
{"token": ["A", "number", "of", "C0032144#ent", "<e1>", "constructed", "from", "the", "C0032143#ent", "<e2>", "and", "u-PA", "cDNAs", "and", "expressed", "using", "a", "bovine", "papilloma", "virus", "vector", "mouse", "C-127", "cells", "."], "h": {"id": "C0032144", "name": "C0032144#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "report", "that", "the", "vampire", "bat", "C0032144#ent", "<e1>", "Bat-PA", ",", "is", "homologous", "to", "tissue-type", "plasminogen", "activator", "C0032143#ent", "<e2>", ")", "but", "contains", "neither", "a", "kringle", "2", "domain", "a", "plasmin-sensitive", "processing", "site", "."], "h": {"id": "C0032144", "name": "C0032144#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [18, 19]}}
{"token": ["The", "transcriptional", "repressor", "activity", "C1825588#ent", "<e1>", "is", "reduced", "by", "C2827461#ent", "<e2>", "."], "h": {"id": "C1825588", "name": "C1825588#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2827461", "name": "C2827461#ent", "pos": [9, 10]}}
{"token": ["The", "protein", "sequence", "encoded", "by", "the", "last", "four", "exons", "of", "the", "C1366358#ent", "<e1>", "some", "homology", "to", "two", "regions", "of", "the", "C1415712#ent", "<e2>"], "h": {"id": "C1366358", "name": "C1366358#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415712", "name": "C1415712#ent", "pos": [20, 21]}}
{"token": ["In", "vitro", "antimicrobial", "activity", "pharmacokinetics", "studies", "that", "C0040263#ent", "<e1>", "has", "minor", "but", "possibly", "relevant", "C1136254#ent", "<e2>", "as", "well", "as", "pharmacokinetic", "advantages", "when", "compared", "directly", "with", "metronidazole", "."], "h": {"id": "C0040263", "name": "C0040263#ent", "pos": [7, 8]}, "relation": "has_therapeutic_class", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [14, 15]}}
{"token": ["In", "vitro", "antimicrobial", "activity", "pharmacokinetics", "studies", "that", "when", "compared", "directly", "with", "metronidazole", ",", "C0040263#ent", "<e1>", "has", "minor", "but", "possibly", "relevant", "C1136254#ent", "<e2>", "as", "well", "as", "pharmacokinetic", "advantages", "."], "h": {"id": "C0040263", "name": "C0040263#ent", "pos": [13, 14]}, "relation": "has_therapeutic_class", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [20, 21]}}
{"token": ["The", "anti-inflammatory", "role", "these", "regulators", "in", "C0038013#ent", "<e1>", "highlighted", "by", "their", "induction", "with", "IFN-gamma", "and", "C0011777#ent", "<e2>", ",", "whilst", "the", "pro-inflammatory", "cytokine", "TNF-alpha", "had", "no", "effect"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [15, 16]}}
{"token": ["The", "involvement", "of", "the", "C0812219#ent", "<e1>", "c-fos", "and", "c-jun", "in", "the", "immediate", "C0599295#ent", "<e2>", "pig", "dermis", "cells", "studied", "after", "in", "vivo", "gamma-irradiation", "."], "h": {"id": "C0812219", "name": "C0812219#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [12, 13]}}
{"token": ["The", "question", "of", "whether", "or", "not", "a", "resection", "of", "the", "C0014852#ent", "<e1>", "be", "included", "in", "the", "surgical", "reconstruction", "procedure", "the", "C0014866#ent", "<e2>", "to", "be", "a", "controversial", "."], "h": {"id": "C0014852", "name": "C0014852#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014866", "name": "C0014866#ent", "pos": [20, 21]}}
{"token": ["The", "quinazoline", "based", "alpha(1)-antagonists", ",", "doxazosin", "and", "C0076107#ent", "<e1>", "but", "not", "tamsulosin", "(", "a", "C0038760#ent", "<e2>", "suppress", "prostate", "growth", "affecting", "cell", "proliferation"], "h": {"id": "C0076107", "name": "C0076107#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [14, 15]}}
{"token": ["In", "addition", "to", "malaria", ",", "penguins", "showed", "evidence", "of", "aspergillosis", ",", "C0014335#ent", "<e1>", "Escherichia", "coli", "Proteus", "sp.", "and", "Edwardsiella", "sp.", ",", "and", "C0018889#ent", "<e2>", "(", "Contracaecum", "sp.", "Tetrabothrius", "sp.", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [22, 23]}}
{"token": ["We", "concluded", "that", "NSAIDs-induced", "apoptosis", "in", "colon", "cancer", "cells", "be", "independent", "from", "signals", "transducted", "through", "[Ca++]i", ",", "C1705341#ent", "<e1>", ",", "PKA", ",", "PKC", "or", "the", "expression", "of", "C1419987#ent", "<e2>"], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419987", "name": "C1419987#ent", "pos": [27, 28]}}
{"token": ["Zymographs", "of", "EGCG-treated", "culture", "supernatants", "modulated", "the", "gelatinolytic", "activities", "of", "secreted", "proteinases", "indicating", "that", "C0059438#ent", "<e1>", "may", "be", "exerting", "its", "inhibitory", "effect", "by", "C0030940#ent", "<e2>"], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [23, 24]}}
{"token": ["(Rp)-Adenosine", "3',5'-monophosphorothioate", "(", "(Rp)-cAMPS", ")", "is", "a", "highly", "specific", "antagonist", "of", "the", "C0010531#ent", "<e1>", "eukaryotic", "cells", "is", "a", "very", "poor", "substrate", "for", "C0757672#ent", "<e2>", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0757672", "name": "C0757672#ent", "pos": [22, 23]}}
{"token": ["They", "sequester", "PKA", "(", "C0010531#ent", "<e1>", "and", "other", "signalling", "molecules", "C0757672#ent", "<e2>", ",", "other", "protein", "kinases", "protein", "phosphatases", "specific", "subcellular", "compartments", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0757672", "name": "C0757672#ent", "pos": [10, 11]}}
{"token": ["Also", ",", "phosphorylation", "of", "Ser225", "enhances", "the", "membrane", "affinity", "plasma", "membrane", "of", "C1332727#ent", "<e1>", ",", "presumably", "by", "modulating", "the", "interaction", "of", "C1419244#ent", "<e2>", "and", "Asn89", "with", "the", "membrane", "."], "h": {"id": "C1332727", "name": "C1332727#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419244", "name": "C1419244#ent", "pos": [21, 22]}}
{"token": ["Inhibition", "of", "CaR", "expression", "blocked", "the", "Ca(2+)(o)-induced", "tyrosine", "phosphorylation", "of", "beta-", ",", "gamma-", ",", "and", "p120-catenin", ",", "PI3K", "and", "the", "C1442788#ent", "<e1>", "the", "association", "of", "C0812303#ent", "<e2>", "with", "E-cadherin", "and", "PI3K"], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [20, 21]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812303", "name": "C0812303#ent", "pos": [25, 26]}}
{"token": ["The", "C1442788#ent", "<e1>", "critical", "since", "BDNF-dependent", "phosphorylation", "was", "abolished", "in", "C0812303#ent", "<e2>", "knockout", "mice"], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812303", "name": "C0812303#ent", "pos": [10, 11]}}
{"token": ["Common", "laboratory", "findings", "include", "cytopenia", ",", "elevated", "liver", "enzymes", "C0020433#ent", "<e1>", ",", "hypofibrinogenaemia", "and", "C0020557#ent", "<e2>", "."], "h": {"id": "C0020433", "name": "C0020433#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [14, 15]}}
{"token": ["S6", "was", "the", "only", "basic", "C0031686#ent", "<e1>", ",", "while", "the", "other", "four", "were", "C0815040#ent", "<e2>", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "whether", "this", "sequence", "acts", "as", "a", "sorting", "signal", "S.pombe", "we", "expressed", "an", "C0031686#ent", "<e1>", "at", "its", "C-terminus", "with", "the", "C0815040#ent", "<e2>"], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [21, 22]}}
{"token": ["The", "C0031686#ent", "<e1>", "is", "highly", "C0815040#ent", "<e2>", "due", "to", "its", "high", "content", "of", "dicarboxylic", "acids", "addition", "to", "the", "presence", "of", "organic", "phosphorus"], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [5, 6]}}
{"token": ["These", "results", "suggest", "that", "PGE2", "stimulates", "NO", "formation", "by", "C0389995#ent", "<e1>", "via", "EP3", ",", "a", "mechanism(s", ")", "different", "from", "C1824717#ent", "<e2>", "and", "EP4", "."], "h": {"id": "C0389995", "name": "C0389995#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1824717", "name": "C1824717#ent", "pos": [19, 20]}}
{"token": ["Conversely", ",", "if", "the", "number", "of", "C1705462#ent", "<e1>", "C0014442#ent", "<e2>", "of", "the", "tricarboxylic", "acid", "cycle", "exceeds", "the", "C1705462#ent", "<e1>", "C0014442#ent", "<e2>", "of", "glycolysis", ",", "an", "aerobic", "metabolism", "preferred", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705462", "name": "C1705462#ent", "pos": [6, 7]}}
{"token": ["This", "genetic", "susceptibility", "COPD", "might", "depend", "on", "variations", "in", "C0014442#ent", "<e1>", "activities", "that", "detoxify", "cigarette", "smoke", "products", "as", "microsomal", "epoxide", "hydrolase", "C1705462#ent", "<e2>", ")", "and", "glutathione-S", "transferase", "GST", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705462", "name": "C1705462#ent", "pos": [21, 22]}}
{"token": ["P450", "isoform-specific", "inhibitors", ",", "monoclonal", "antibodies", "against", "P450", "isoforms", "and", "recombinantly", "expressed", "human", "P450", "C0014442#ent", "<e1>", "were", "used", "to", "define", "the", "P450", "isoform", "profile", "of", "C1705462#ent", "<e2>", "4-monohydroxylations", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705462", "name": "C1705462#ent", "pos": [25, 26]}}
{"token": ["C1335892#ent", "<e1>", "from", "FMLP-activated", ",", "adherent", "PMNs", "phosphorylated", "C0537086#ent", "<e2>", "suggesting", "that", "paxillin", "is", "a", "substrate", "for", "C1335892#ent", "<e1>", "in", "vivo"], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [0, 1]}}
{"token": ["Finally", ",", "we", "show", "that", "Xenopus", "C3539645#ent", "<e1>", "and", "its", "binding", "partner", "C1705807#ent", "<e2>", "also", "essential", "for", "gastrulation", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705807", "name": "C1705807#ent", "pos": [12, 13]}}
{"token": ["To", "investigate", "the", "prevalence", "of", "C0008149#ent", "<e1>", "their", "significance", "for", "reproductive", "disorders", "sow", "breeding", "C1519228#ent", "<e2>", "in", "Germany", ",", "blood", "samples", "1493", "pigs", "were", "taken", "for", "a", "serological", "survey", "enzyme-linked-immunosorbent-assay", "(ELISA", "."], "h": {"id": "C0008149", "name": "C0008149#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1519228", "name": "C1519228#ent", "pos": [14, 15]}}
{"token": ["Potential", "C0035064#ent", "<e1>", "for", "inducing", "conformational", "changes", "tau", ",", "namely", "C0051510#ent", "<e2>", "and", "glutamate", ",", "were", "investigated", "in", "this", "study", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0051510", "name": "C0051510#ent", "pos": [10, 11]}}
{"token": ["C0538927#ent", "<e1>", "single", "agent", "also", "inhibit", "AKT", "and", "C0752312#ent", "<e2>", "pathway", "in", "NSCLC", ",", "even", "the", "EGFR", "expression", "under", "high", "concentration", "treatment", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [8, 9]}}
{"token": ["C0012403#ent", "<e1>", "DMSO", ")", "was", "the", "diluent", "for", "all", "C0678133#ent", "<e2>", "stock", "solutions", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0678133", "name": "C0678133#ent", "pos": [9, 10]}}
{"token": ["The", "delay", "in", "cerebral", "evoked", "potentials", "mostly", "attributable", "to", "C0031117#ent", "<e1>", "no", "firm", "evidence", "was", "obtained", "in", "favour", "of", "C0011882#ent", "<e2>"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011882", "name": "C0011882#ent", "pos": [19, 20]}}
{"token": ["The", "possible", "basis", "for", "this", "ganglioside", "effect", "experimental", "C0031117#ent", "<e1>", "its", "significance", "for", "the", "treatment", "of", "human", "C0011882#ent", "<e2>", "discussed", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011882", "name": "C0011882#ent", "pos": [17, 18]}}
{"token": ["The", "pyrophosphate", "exchange", "reaction", "with", "the", "C1335440#ent", "<e1>", "temperature-sensitive", "which", "demonstrates", "that", "pyrophosphate", "exchange", "indeed", "catalyzed", "by", "the", "C0012892#ent", "<e2>", "that", "the", "same", "mutation", "effects", "both", "DNA", "polymerase", "pyrophosphatase", "activity"], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [18, 19]}}
{"token": ["The", "elevated", "temperature", "requirement", ",", "small", "size", "and", "lack", "of", "nuclease", "activity", "this", "C1335440#ent", "<e1>", "from", "the", "C0012892#ent", "<e2>", "Escherichia", "coli"], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [17, 18]}}
{"token": ["There", "is", "major", "evidence", "for", "considering", "C0376670#ent", "<e1>", "a", "chronic", "disease", "initio", "while", "chronic", "pancreatitis", "lesions", "detectable", "in", "biliary", "acute", "recurrent", "pancreatitis", "C1705841#ent", "<e2>", ")", "seem", "a", "casual", "association", "."], "h": {"id": "C0376670", "name": "C0376670#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705841", "name": "C1705841#ent", "pos": [22, 23]}}
{"token": ["The", "occurrence", "of", "antibodies", "in", "human", "serum", "that", "block", "herpes", "simplex", "virus", "C0019348#ent", "<e1>", ")", "type", "1", "and", "C0040078#ent", "<e2>", "dTK", ")", "has", "been", "investigated", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040078", "name": "C0040078#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "the", "role", "of", "C1706046#ent", "<e1>", "the", "chromosomal", "abnormalities", "ATLL", "by", "investigating", "mutations", "of", "hBUB1", "and", "C2987245#ent", "<e2>", ",", "and", "MIN", "of", "replication", "errors", "BAX", ",", "insulin-like", "growth", "factor", "and", "transforming", "growth", "factor", "beta", "type", "II"], "h": {"id": "C1706046", "name": "C1706046#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987245", "name": "C2987245#ent", "pos": [17, 18]}}
{"token": ["Neither", "TAT-dnRas", "nor", "PD98059", "blocked", "C1306759#ent", "<e1>", "adhesion", "to", "C1706544#ent", "<e2>", ",", "up-regulation", "of", "CBRM1/5", ",", "or", "focal", "surface", "clustering", "of", "Mac-1", "caused", "by", "PMA", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "alpha(5)beta(1)", "integrin", "provide", "a", "contact-dependent", "costimulus", "for", "C1306759#ent", "<e1>", "priming", "that", ",", "together", "with", "TNF-alpha", ",", "potentiated", "C5a", "activation", "of", "alpha(M)beta(2)", "integrin", "increased", "C1306759#ent", "<e1>", "adhesion", "to", "C1706544#ent", "<e1>", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [30, 31]}}
{"token": ["We", "have", "reported", "previously", "that", "HIV-TAT-dominant", "negative", "(", "dn", ")", "Ras", "inhibits", "C1306759#ent", "<e1>", "adhesion", "to", "C1706544#ent", "<e2>", "after", "activation", "by", "IL-5", "and", "eotaxin", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [16, 17]}}
{"token": ["Metalloproteinases", "that", "show", "increased", "expression", "in", "painful", "tendinopathy", "C2984597#ent", "<e1>", "(", "a", "disintegrin", "and", "metalloproteinase)-12", "and", "C0919336#ent", "<e2>", "(", "matrix", "metalloproteinase)-23", "."], "h": {"id": "C2984597", "name": "C2984597#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [16, 17]}}
{"token": ["We", "have", "introduced", "the", "gene", "(", "E*01033", ")", "encoding", "the", "C1420192#ent", "<e1>", "human", "nonclassical", "MHC", "class", "I", "Ag", ",", "C1415585#ent", "<e2>", ",", "into", "the", "mouse", "genome", "."], "h": {"id": "C1420192", "name": "C1420192#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415585", "name": "C1415585#ent", "pos": [19, 20]}}
{"token": ["C0034861#ent", "<e1>", "expressed", "in", "Escherichia", "coli", "reduced", "9,10-phenanthraquinone", "with", "C0068341#ent", "<e2>", "as", "cofactor", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0068341", "name": "C0068341#ent", "pos": [9, 10]}}
{"token": ["In", "6", "cases", "of", "PLAF", ",", "2", "were", "negative", "for", "C3274837#ent", "<e1>", ",", "both", "by", "C4284041#ent", "<e2>", "and", "calponin", ",", "and", "a", "malignant", "papillary", "lesion", "was", "confirmed", "by", "histology", "."], "h": {"id": "C3274837", "name": "C3274837#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4284041", "name": "C4284041#ent", "pos": [15, 16]}}
{"token": ["The", "total", "plasma", "clearance", "of", "C0056512#ent", "<e1>", "was", "greater", "than", "that", "of", "C0056521#ent", "<e2>", "and", "both", "values", "were", "greater", "than", "5", "ml", "min-1", "kg-1", "."], "h": {"id": "C0056512", "name": "C0056512#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0056521", "name": "C0056521#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "T", "C1332691#ent", "<e1>", "SOCS-1-conditional", "knockout", "mice", "more", "severe", "colitis", "than", "control", "mice", "C0011195#ent", "<e2>", "administration", "."], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011195", "name": "C0011195#ent", "pos": [14, 15]}}
{"token": ["The", "C0017360#ent", "<e1>", "HIV-1", "encodes", "for", "three", "essential", "C0014442#ent", "<e2>", ",", "protease", "(", "PR", ")", ",", "reverse", "transcriptase", "RT", ")", "and", "integrase", "(", "IN", ")", "."], "h": {"id": "C0017360", "name": "C0017360#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}}
{"token": ["C1419101#ent", "<e1>", "activates", "src", "tyrosine", "kinase", "increases", "the", "magnitude", "and", "duration", "of", "C1367721#ent", "<e2>", "EGF", ")", "signaling", "."], "h": {"id": "C1419101", "name": "C1419101#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [12, 13]}}
{"token": ["C1413858#ent", "<e1>", "is", "the", "single", "enzyme", "mediating", "both", "17", "C0038302#ent", "<e2>", "and", "17,20", "lyase", "activities", "."], "h": {"id": "C1413858", "name": "C1413858#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0038302", "name": "C0038302#ent", "pos": [9, 10]}}
{"token": ["Addition", "of", "C1516312#ent", "<e1>", "Z-DEVD-FMK", ",", "inhibited", "formation", "of", "some", "fragments", "of", "C1704976#ent", "<e2>", ",", "and", "caspase-3", "was", "proteolytically", "activated", "by", "TAM", "treatment", "."], "h": {"id": "C1516312", "name": "C1516312#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704976", "name": "C1704976#ent", "pos": [12, 13]}}
{"token": ["By", "use", "of", "allele-specific", "PCR", "analysis", ",", "the", "wild", "type", "allele", "CYP2D6*1A", "and", "four", "C0002085#ent", "<e1>", "either", "absent", "(", "C1707222#ent", "<e2>", "CYP2D6*4", "CYP2D6*5", "or", "decreased", "(", "CYP2D6*10", "CYP2D6", "activity", "identified", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1707222", "name": "C1707222#ent", "pos": [19, 20]}}
{"token": ["A", "six-month", "single-blind", ",", "randomized", "parallel", "group", "study", "the", "effects", "of", "fenclofenac", "and", "C0700583#ent", "<e1>", "in", "63", "patients", "with", "C0038013#ent", "<e2>", "described", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "its", "superior", "safety", "profile", "suggests", "that", "C0700583#ent", "<e1>", "will", "be", "a", "valuable", "agent", "in", "the", "treatment", "of", "C0038013#ent", "<e2>", "for", "which", "long-term", "drug", "therapy", "usually", "required", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [20, 21]}}
{"token": ["The", "chemical", "composition", "thermal", "behaviour", "mechanical", "properties", "of", "three", "tooth", "positioner", "materials", ",", "Urethane", "P1", "C1418887#ent", "<e1>", ")", ",", "White", "Rubber", "WR", ")", "and", "Elastocryl", "(", "C1823249#ent", "<e2>", ")", "were", "investigated", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1823249", "name": "C1823249#ent", "pos": [26, 27]}}
{"token": ["In", "this", "work", "we", "demonstrate", "that", "C1424931#ent", "<e1>", "and", "Tpk2", ",", "the", "catalytic", "subunits", "C1514550#ent", "<e2>", "are", "involved", "in", "the", "signalling", "of", "short-term", "and", "long-term", "inactivation", "processes", "of", "Icl", "."], "h": {"id": "C1424931", "name": "C1424931#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [14, 15]}}
{"token": ["A", "complete", "human", "C1366623#ent", "<e1>", "been", "isolated", "from", "a", "lambda", "phage", "genomic", "library", "cloned", "mouse", "C0001414#ent", "<e2>", "DNA", "as", "a", "probe", "."], "h": {"id": "C1366623", "name": "C1366623#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0001414", "name": "C0001414#ent", "pos": [15, 16]}}
{"token": ["Dexamethasone", "(", "C0011816#ent", "<e1>", ")", ",", "a", "synthetic", "glucocorticoid", "also", "had", "no", "effect", "C3541302#ent", "<e2>", "during", "the", "first", "or", "second", "weeks", "in", "culture", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541302", "name": "C3541302#ent", "pos": [13, 14]}}
{"token": ["In", "the", "adrenal", "glands", "hypophysectomized", "(", "HPX'd", ")", "rats", ",", "the", "synthetic", "glucocorticoid", "dexamethasone", "(", "C0011816#ent", "<e1>", ")", "stimulates", "production", "of", "C3541302#ent", "<e2>", "mRNA", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3541302", "name": "C3541302#ent", "pos": [21, 22]}}
{"token": ["Non-dopaminergic", "drugs", "either", "on", "adenosine", "A2A", "or", "C1333711#ent", "<e1>", "mGlu", ")", "receptors", "reduce", "motor", "impairment", "animal", "models", "Parkinson's", "disease", "C3160718#ent", "<e2>", ")", ",", "suggesting", "a", "possible", "functional", "interaction", "between", "these", "receptors", "to", "regulate", "basal", "ganglia", "function", "."], "h": {"id": "C1333711", "name": "C1333711#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [19, 20]}}
{"token": ["Despite", "inducing", "an", "expressive", "down-regulation", "of", "Bax", ",", "C3890603#ent", "<e1>", "was", "also", "able", "to", "induce", "C1709384#ent", "<e2>", "cleavage", "."], "h": {"id": "C3890603", "name": "C3890603#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1709384", "name": "C1709384#ent", "pos": [15, 16]}}
{"token": ["Other", "C0002085#ent", "<e1>", "of", "unc-79", "are", "also", "associated", "with", "hypersensitivity", "to", "C0018549#ent", "<e2>", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [11, 12]}}
{"token": ["From", "December", "1973", "to", "December", "1987", ",", "we", "performed", "a", "distal", "splenorenal", "shunt", "DSRS", ")", "in", "112", "cases", "of", "C0020541#ent", "<e1>", "including", "107", "with", "postnecrotic", "liver", "cirrhosis", "5", "with", "C0085580#ent", "<e2>", "IPH", ")", "."], "h": {"id": "C0020541", "name": "C0020541#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [29, 30]}}
{"token": ["The", "most", "frequent", "adverse", "drug", "reactions", "C0005064#ent", "<e1>", "are", "drowsiness", ",", "depression", ",", "impaired", "intellectual", "function", "memory", ",", "C0023380#ent", "<e2>", ",", "impaired", "coordination", ",", "dizziness", ",", "nausea", "and/or", "vomiting", ",", "skin", "rash", "and", "respiratory", "disturbance"], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [18, 19]}}
{"token": ["The", "study", "states", "that", "C0022642#ent", "<e1>", "%", "eye", "drops", "effective", "in", "a", "monotherapy", "of", "C0009766#ent", "<e2>"], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [14, 15]}}
{"token": ["Cellular", "C0206256#ent", "<e1>", "rapidly", "induced", "by", "a", "diverse", "range", "of", "C0991617#ent", "<e2>", "and", "conditions", "."], "h": {"id": "C0206256", "name": "C0206256#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [10, 11]}}
{"token": ["The", "fucosyltransferase", "that", "constructs", "the", "non-sialylated", "antigen", ",", "C1429589#ent", "<e1>", "CD15", ")", ",", "is", "expressed", "at", "high", "levels", "C1414865#ent", "<e2>", ")", "."], "h": {"id": "C1429589", "name": "C1429589#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414865", "name": "C1414865#ent", "pos": [18, 19]}}
{"token": ["This", "report", "characterizes", "a", "murine", "alpha", "1", "-", "3FT", "that", "shares", "77", "%", "amino", "acid", "sequence", "with", "human", "ELAM", "C1429589#ent", "<e1>", "ELFT", ",", "also", "termed", "C1414865#ent", "<e2>"], "h": {"id": "C1429589", "name": "C1429589#ent", "pos": [19, 20]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414865", "name": "C1414865#ent", "pos": [25, 26]}}
{"token": ["This", "protein(s", ")", "might", "be", "an", "amphibian", "C1334043#ent", "<e1>", "of", "mammalian", "C0618743#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [11, 12]}}
{"token": ["A", "non-Jewish", "patient", "is", "described", "who", "had", "adult", "polyglucosan", "body", "disease", "APBD", ")", "and", "C0085798#ent", "<e1>", "GBE", ")", "deficiency", "without", "C0772125#ent", "<e2>", "mutation", "."], "h": {"id": "C0085798", "name": "C0085798#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0772125", "name": "C0772125#ent", "pos": [20, 21]}}
{"token": ["FGF20", ",", "C1416525#ent", "<e1>", "and", "DKK1", "are", "target", "C1417679#ent", "<e2>", "of", "the", "WNT-beta-catenin", "signaling", "cascade", "."], "h": {"id": "C1416525", "name": "C1416525#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}}
{"token": ["The", "C0025517#ent", "<e1>", "white", "matter", "involvement", "and", "the", "recently", "described", "C1858991#ent", "<e2>", "(", "Van", "Der", "Knaap", "disease", ",", "'", "vanishing", "white", "matter", "disease", ")", "were", "excluded", "based", "on", "clinical", ",", "biologic", "and", "imaging", "findings", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1858991", "name": "C1858991#ent", "pos": [10, 11]}}
{"token": ["The", "order", "of", "potency", "for", "inducing", "current", "responses", "in", "the", "oocyte", "membrane", "was", "kainate", "greater", "than", "glutamate", "=", "C0022614#ent", "<e1>", "much", "greater", "than", "C0080073#ent", "<e2>", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0080073", "name": "C0080073#ent", "pos": [23, 24]}}
{"token": ["The", "binary", "mixture", "of", "cyproterone", "and", "C0543495#ent", "<e1>", "significantly", "down-regulated", "expression", "of", "C3254086#ent", "<e2>", ",", "while", "a", "mixture", "of", "ethynylestradiol", "and", "trenbolone", ",", "increased", "E2", "production", "3.7-fold", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3254086", "name": "C3254086#ent", "pos": [12, 13]}}
{"token": ["OaGST", "is", "a", "constitutive", "C0027203#ent", "<e1>", "which", "is", "also", "inducible", "by", "several", "C0304402#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [12, 13]}}
{"token": ["Hormone", "receptors", "estrogen", "(", "ER", ")", ",", "C2757070#ent", "<e1>", "(", "PGR", ")", "and", "prolactin", "(", "C1419090#ent", "<e2>", ")", "were", "measured", "in", "primary", "breast", "cancer", "tissues", "obtained", "from", "214", "patients", "at", "radical", "mastectomy"], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419090", "name": "C1419090#ent", "pos": [15, 16]}}
{"token": ["Thirty", "three", "patients", "were", "administered", "C0061851#ent", "<e1>", "and", "31", "patients", "were", "administered", "C0700583#ent", "<e2>"], "h": {"id": "C0061851", "name": "C0061851#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [12, 13]}}
{"token": ["C0061851#ent", "<e1>", "was", "not", "superior", "to", "C0700583#ent", "<e2>", "relieving", "pain", "in", "patients", "with", "acute", "ureteral", "colic"], "h": {"id": "C0061851", "name": "C0061851#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [6, 7]}}
{"token": ["Pharmacologically", "the", "transporter", "is", "distinct", "from", "the", "other", "human", "GABA", "transporters", "and", "similar", "to", "rat", "C3889419#ent", "<e1>", "and", "mouse", "C1420208#ent", "<e2>", "with", "high", "sensitivity", "toward", "GABA", "and", "beta-alanine", "."], "h": {"id": "C3889419", "name": "C3889419#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420208", "name": "C1420208#ent", "pos": [19, 20]}}
{"token": ["C0038160#ent", "<e1>", "most", "common", ",", "but", "C0275524#ent", "<e2>", "often", "seen", "in", "immunocompromised", "patients", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "this", "C1254351#ent", "<e1>", "inhibited", "the", "gene", "expression", "T-helper", "type", "1", "C1423842#ent", "<e2>", ")", "cytokines", "such", "as", "IL-2", "and", "IFN-gamma", "of", "lymph", "node", "cells", "mice", "immuned", "by", "TNCB", "or", "of", "Con", "A-stimulated", "spleen", "cells", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [12, 13]}}
{"token": ["Although", "10", "mg/day", "of", "oral", "C0032950#ent", "<e1>", "was", "administered", ",", "low", "levels", "of", "serum", "complement", "proteinuria", ",", "C0040034#ent", "<e2>", "(", "6.0", "x", "10(4)/mm3", ")", "and", "biological", "false", "positive", "STS", "continued", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [17, 18]}}
{"token": ["As", "evoking", "cause", "an", "immunesuppressive", "treatment", "with", "cyclophosphamide", "or", "C0032950#ent", "<e1>", ",", "respectively", ",", "on", "account", "of", "chronic", "lymphadenosis", "excessive", "C0040034#ent", "<e2>", "is", "discussed", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [20, 21]}}
{"token": ["A", "51-year-old", "male", "diagnosed", "as", "having", "Evans's", "syndrome", "1991", "was", "treated", "with", "mg", "of", "C0032950#ent", "<e1>", ",", "but", "his", "anemia", "and", "C0040034#ent", "<e2>", "progressed", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [21, 22]}}
{"token": ["To", "assess", "the", "efficacy", "and", "safety", "of", "ezetimibe", "coadministered", "with", "C0074554#ent", "<e1>", "in", "patients", "with", "C0020443#ent", "<e2>", "coronary", "artery", "disease", "CAD", ")", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [15, 16]}}
{"token": ["C0074554#ent", "<e1>", "led", "to", "significant", "reduction", "in", "total", "cholesterol", "trigliceride", "levels", "normocholesterolaemic", "and", "C0020443#ent", "<e2>", "patients", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [13, 14]}}
{"token": ["Successive", "stages", "in", "the", "progression", "of", "C3534591#ent", "<e1>", "appear", "to", "be", "controlled", "by", "distinct", "C0017337#ent", "<e2>", "or", "sets", "of", "C0017337#ent", "<e2>", "."], "h": {"id": "C3534591", "name": "C3534591#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["These", "glial", "fibrillary", "acidic", "protein-IFN-alpha", "transgenic", "mice", "a", "progressive", "C0027121#ent", "<e1>", "with", "marked", "calcium", "mineralization", "C0025309#ent", "<e2>", ",", "gliosis", ",", "and", "neurodegeneration", "."], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025309", "name": "C0025309#ent", "pos": [15, 16]}}
{"token": ["That", "is", ",", "the", "separation", "was", "related", "to", "the", "molecular", "size", "distribution", ",", "C0217598#ent", "<e1>", "content", "and", "C0003280#ent", "<e2>", "activities", "."], "h": {"id": "C0217598", "name": "C0217598#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [17, 18]}}
{"token": ["IL-4", "induced", "phosphorylation", "of", "C1456378#ent", "<e1>", "stress-activated", "protein", "kinase/c-Jun", "kinase", "and", "p42/44", "mitogen-activated", "protein", "kinase", "inhibitors", "of", "these", "C0031727#ent", "<e2>", "suppressed", "IL-4-induced", "proliferation", "of", "endometriotic", "stromal", "cells"], "h": {"id": "C1456378", "name": "C1456378#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}}
{"token": ["Tetracaine", "alone", ",", "but", "not", "the", "other", "local", "anesthetics", "inhibited", "LPS", "activation", "of", "C1456378#ent", "<e1>", "MAPK", ")", "and", "MAPK", "kinase", "3", "C0031727#ent", "<e2>", "in", "the", "LPS", "signaling", "pathway", "."], "h": {"id": "C1456378", "name": "C1456378#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["Six", "patients", "had", "one", "or", "more", "abnormalities", "of", "regulatory", "proteins", "protein", "S", "deficiency", "four", ";", "C0033626#ent", "<e1>", "three", ";", "presence", "of", "lupus-like", "anticoagulant", "three", ";", "C0398621#ent", "<e2>", "two", ")", "."], "h": {"id": "C0033626", "name": "C0033626#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0398621", "name": "C0398621#ent", "pos": [25, 26]}}
{"token": ["C0033626#ent", "<e1>", "combined", "with", "protein", "C", "deficiency", "3", "cases", ",", "C0398621#ent", "<e2>", "2", "cases", "and", "reduced", "fibrinolytic", "capacity", "two", "."], "h": {"id": "C0033626", "name": "C0033626#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0398621", "name": "C0398621#ent", "pos": [10, 11]}}
{"token": ["Myelin", "protein", "zero", "C1417248#ent", "<e1>", "or", "P0", "glycoprotein", ",", "the", "major", "C1823138#ent", "<e2>", "peripheral", "nervous", "system", "myelin", "plays", "a", "key", "role", "in", "myelin", "membrane", "compaction", "stability", "."], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823138", "name": "C1823138#ent", "pos": [11, 12]}}
{"token": ["The", "short", "term", "long", "term", "tolerability", "of", "C0013065#ent", "<e1>", "was", "inferior", "to", "that", "of", "C0016365#ent", "<e2>", "."], "h": {"id": "C0013065", "name": "C0013065#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [14, 15]}}
{"token": ["A", "subepicardial", "lymph", "vessel", "the", "left", "anterior", "descending", "coronary", "artery", "C1706333#ent", "<e1>", ")", "was", "cannulated", "directly", "with", "a", "small", "polyethylene", "tube", "and", "lymph", "flow", "C2986618#ent", "<e2>", ")", "and", "protein", "concentration", "lymph", "(", "PC", ")", "were", "measured", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2986618", "name": "C2986618#ent", "pos": [24, 25]}}
{"token": ["C1537422#ent", "<e1>", "mRNA", "induction", "is", "also", "inhibited", "by", "C0011777#ent", "<e2>", ",", "a", "synthetic", "glucocorticoid", "well", "known", "as", "an", "anti-inflammatory", "drug", "of", "influencing", "gene", "expression", "macrophages", "."], "h": {"id": "C1537422", "name": "C1537422#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [8, 9]}}
{"token": ["Mutations", "in", "the", "gene", "encoding", "lamins", "A", "C", "(", "C1416877#ent", "<e1>", ")", "cause", "primary", "laminopathies", ",", "including", "various", "types", "of", "C0221032#ent", "<e2>", ",", "muscular", "dystrophies", "progeroid", "syndromes", "mandibuloacral", "dysplasia", "dilated", "cardiomyopathies", "and", "restrictive", "dermopathy"], "h": {"id": "C1416877", "name": "C1416877#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0221032", "name": "C0221032#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "mutations", "in", "C1416877#ent", "<e1>", "give", "rise", "to", "a", "dilated", "cardiomyopathy", "a", "C0221032#ent", "<e2>", "or", "a", "neuropathy", "."], "h": {"id": "C1416877", "name": "C1416877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0221032", "name": "C0221032#ent", "pos": [14, 15]}}
{"token": ["Genomic", "DNA", "mutations", "the", "nuclear", "lamina", "protein", "C1416877#ent", "<e1>", "inherited", "partial", "C0221032#ent", "<e2>", "but", "are", "not", "found", "in", "patients", "with", "APL", "."], "h": {"id": "C1416877", "name": "C1416877#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221032", "name": "C0221032#ent", "pos": [11, 12]}}
{"token": ["One", "chemical", ",", "oxytriazine", ",", "was", "found", "to", "induce", "C1428340#ent", "<e1>", "expression", "in", "the", "absence", "of", "C1421554#ent", "<e2>", "."], "h": {"id": "C1428340", "name": "C1428340#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421554", "name": "C1421554#ent", "pos": [16, 17]}}
{"token": ["Structure-activity", "relationships", "these", "agents", "as", "being", "as", "effective", "as", "C0073096#ent", "<e1>", "with", "respect", "to", "their", "ability", "to", "specifically", "inactivate", "C1415652#ent", "<e2>", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [19, 20]}}
{"token": ["Cardiovascular", "disease", "CVD", ")", ",", "including", "C0004153#ent", "<e1>", ",", "hypertension", ",", "myocardial", "infarction", "and", "C0038454#ent", "<e2>", "constitutes", "an", "important", "cause", "of", "morbidity", "and", "mortality", "in", "adults", "with", "chronic", "kidney", "disease", "CKD", ")", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [14, 15]}}
{"token": ["The", "authors", "report", "the", "first", "case", "of", "chylous", "ascites", "C0159075#ent", "<e1>", "in", "a", "65-year-old", "Thai", "women", "with", "nephrotic", "syndrome", "to", "focal", "segmental", "glomerulosclerosis", "C0017668#ent", "<e2>", ")", ",", "tip", "variant"], "h": {"id": "C0159075", "name": "C0159075#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [23, 24]}}
{"token": ["The", "liver", "is", "one", "of", "the", "main", "target", "organs", "of", "Marburg", "virus", "MBG", ")", ",", "a", "filovirus", "causing", "severe", "C0019100#ent", "<e1>", "a", "high", "fatality", "rate", "in", "humans", "and", "C1334981#ent", "<e2>"], "h": {"id": "C0019100", "name": "C0019100#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1334981", "name": "C1334981#ent", "pos": [28, 29]}}
{"token": ["Ebola", "and", "Marburg", "viruses", "to", "the", "family", "Filoviridae", "and", "cause", "acute", ",", "frequently", "fatal", ",", "C0019100#ent", "<e1>", "humans", "and", "C1334981#ent", "<e2>"], "h": {"id": "C0019100", "name": "C0019100#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334981", "name": "C1334981#ent", "pos": [19, 20]}}
{"token": ["C0037116#ent", "<e1>", "is", "primarily", "a", "C0024115#ent", "<e2>", "also", "affects", "the", "draining", "lymph", "nodes"], "h": {"id": "C0037116", "name": "C0037116#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [5, 6]}}
{"token": ["Cilostazol", ",", "a", "well-known", "phosphodiesterase", "type", "3", "C2987233#ent", "<e1>", ")", "inhibitor", "for", "the", "treatment", "of", "C1704436#ent", "<e2>", "has", "vasodilator", "properties", "and", "an", "anti-proliferative", "action", "on", "the", "growth", "of", "vascular", "smooth", "muscle", "cells"], "h": {"id": "C2987233", "name": "C2987233#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [15, 16]}}
{"token": ["C1667078#ent", "<e1>", "such", "as", "papain", ",", "ficin", ",", "and", "C0006217#ent", "<e2>", ",", "all", "showed", "toxicity", "."], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006217", "name": "C0006217#ent", "pos": [9, 10]}}
{"token": ["Ovulation", "was", "successfully", "induced", "in", "6/8", "women", "with", "C0271623#ent", "<e1>", "and", "in", "2/2", "women", "with", "C0020514#ent", "<e2>", "but", "in", "only", "3/6", "women", "with", "amenorrhoea", "associated", "with", "elevated", "LH", ":", "FSH", "ratio", "."], "h": {"id": "C0271623", "name": "C0271623#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [15, 16]}}
{"token": ["It", "is", "a", "feature", "of", "the", "reproductive", "endocrine", "disorders", "are", "often", "associated", "with", "epilepsy", ":", "C0271623#ent", "<e1>", "hypergonadotropic", "hypogonadism", "and", "functional", "C0020514#ent", "<e2>", "."], "h": {"id": "C0271623", "name": "C0271623#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [21, 22]}}
{"token": ["C0271623#ent", "<e1>", "was", "noted", "in", "3", "(", "4", "%", ")", "and", "C0020514#ent", "<e2>", "due", "to", "pituitary", "microadenoma", "induced", "infertility", "in", "only", "one", "patient", "."], "h": {"id": "C0271623", "name": "C0271623#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [11, 12]}}
{"token": ["The", "beta-receptor", "blocking", "agents", "atenolol", ",", "C0025859#ent", "<e1>", ",", "pindolol", ",", "alprenolol", ",", "C0030040#ent", "<e2>", "and", "propranolol", "were", "resolved", "on", "a", "CHIRAL-AGP", "column", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030040", "name": "C0030040#ent", "pos": [13, 14]}}
{"token": ["In", "group", "1", "patients", "received", "C0025859#ent", "<e1>", "50", "mg", ",", "in", "group", "2", "patients", "received", "C0025859#ent", "<e1>", "25", "mg", "and", "in", "group", "3", "patients", "received", "C0030040#ent", "<e1>", "20", "mg", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030040", "name": "C0030040#ent", "pos": [25, 26]}}
{"token": ["Sixteen", "patients", "with", "uncomplicated", "hypertension", "were", "studied", "in", "a", "double-blind", "within-patient", "trial", "comparing", "C0025859#ent", "<e1>", "C0030040#ent", "<e2>", "(", "SRO", ")", "with", "conventional", "C0030040#ent", "<e2>", "(", "CO", ")", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030040", "name": "C0030040#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "there", "appears", "to", "be", "a", "direct", "association", "between", "the", "degree", "of", "C1257763#ent", "<e1>", "and", "the", "severity", "of", "C0024115#ent", "<e2>", "which", "in", "turn", "affects", "overall", "prognosis", "."], "h": {"id": "C1257763", "name": "C1257763#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [19, 20]}}
{"token": ["Both", "undernutrition", "and", "C1257763#ent", "<e1>", "can", "affect", "the", "quality", "of", "life", "survival", "of", "patients", "with", "C0024115#ent", "<e2>", "lead", "to", "quantitative", "and", "functional", "alterations", "of", "fat-free", "mass", "FFM", ")", "."], "h": {"id": "C1257763", "name": "C1257763#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [15, 16]}}
{"token": ["Inhibition", "of", "C0949684#ent", "<e1>", "motor", "activity", "live", "cells", "blocks", "appearance", "of", "new", "C1705433#ent", "<e2>", "bundles", "in", "the", "lamella", ",", "without", "inhibition", "of", "cell", "protrusion", "the", "same", "timescale", "."], "h": {"id": "C0949684", "name": "C0949684#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705433", "name": "C1705433#ent", "pos": [12, 13]}}
{"token": ["Associated", "C0949684#ent", "<e1>", "stationary", "with", "respect", "to", "the", "substratum", "in", "new", "C1705433#ent", "<e2>", "bundles", "."], "h": {"id": "C0949684", "name": "C0949684#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705433", "name": "C1705433#ent", "pos": [11, 12]}}
{"token": ["Injection", "with", "1.0", "and", "3.0", "mumole", "of", "acetaldehyde", "induced", "an", "increase", "in", "C0032405#ent", "<e1>", "and", "in", "the", "C0010762#ent", "<e2>", "level", ",", "but", "had", "no", "effect", "DNA", "polymerases"], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [17, 18]}}
{"token": ["Ibandronate", "(", "C0379200#ent", "<e1>", "is", "a", "C0012544#ent", "<e2>", "inhibits", "hone", "resorption", "human", "and", "animal", "studies"], "h": {"id": "C0379200", "name": "C0379200#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "BK", "treatment", "of", "cells", "led", "to", "increased", "C1418617#ent", "<e1>", "activity", "of", "C1333931#ent", "<e2>", "immunoprecipitated", "from", "lysates", "."], "h": {"id": "C1418617", "name": "C1418617#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333931", "name": "C1333931#ent", "pos": [14, 15]}}
{"token": ["Three", "major", "classes", "of", "C1418617#ent", "<e1>", "are", "expressed", "in", "astrocytes", ":", "group", "IV", "calcium-dependent", "cytosolic", "PLA2", "C1333931#ent", "<e2>", ")", ",", "group", "VI", "PLA2", "(", "iPLA2", ")", ",", "and", "group", "II", "PLA2(sPLA2", ")", "."], "h": {"id": "C1418617", "name": "C1418617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333931", "name": "C1333931#ent", "pos": [16, 17]}}
{"token": ["Using", "immunohistology", ",", "the", "C0916743#ent", "<e1>", "detected", "co-expressed", "with", "C1332804#ent", "<e2>", "lung", "and", "bone", "metastases", "both", "the", "murine", "model", "and", "human", "tissues", "."], "h": {"id": "C0916743", "name": "C0916743#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [9, 10]}}
{"token": ["Contrary", "to", "caspase", "inhibitors", "a", "panel", "of", "pharmacological", "cathepsin", "B", "inhibitors", ",", "the", "endogenous", "C0916743#ent", "<e1>", "cystatin", "A", "well", "as", "antisense-mediated", "depletion", "of", "C1332804#ent", "<e2>", "WEHI-S", "cells", "from", "apoptosis", "triggered", "by", "TNF", "or", "TNF-related", "apoptosis-inducing", "ligand"], "h": {"id": "C0916743", "name": "C0916743#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [23, 24]}}
{"token": ["The", "presence", "of", "the", "IL-1A2", "C0002085#ent", "<e1>", "could", "constitute", "a", "risk", "factor", "the", "development", "of", "C0085435#ent", "<e2>", "could", "be", "used", "early", "in", "the", "course", "of", "the", "disease", "as", "a", "prognostic", "marker"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085435", "name": "C0085435#ent", "pos": [15, 16]}}
{"token": ["Two", "cDNA", "clones", "encoding", "two", "different", "C0061415#ent", "<e1>", "AGPase", ")", "polypeptides", "designated", "IbAGP-sTL1", "(", "sTL1", ")", "and", "C1858084#ent", "<e2>", "were", "isolated", "from", "sweet", "potato", "tuberous", "root", "leaf", "libraries", "."], "h": {"id": "C0061415", "name": "C0061415#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1858084", "name": "C1858084#ent", "pos": [17, 18]}}
{"token": ["Baroreflex", "gain", "was", "unaltered", "by", "misoprostol", ",", "as", "were", "plasma", "renin", "activity", ",", "catecholamines", "and", "chromogranin", "A.", "Even", "this", "transient", "C0003364#ent", "<e1>", "abolished", "by", "C0085387#ent", "<e2>", "pretreatment", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [24, 25]}}
{"token": ["These", "proteins", "contain", "a", "conserved", "ATPase", "domain", "include", "C0599220#ent", "<e1>", "of", "the", "C1419021#ent", "<e2>", "and", "are", "homologous", "to", "the", "mammalian", "human", "immunodeficiency", "virus", "protein", "TBP1", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419021", "name": "C1419021#ent", "pos": [12, 13]}}
{"token": ["C3854222#ent", "<e1>", "HIV", ")", "is", "lymphotropic", "and", "C0597058#ent", "<e2>", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597058", "name": "C0597058#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "indicate", "that", "voluminous", "exudation", "caused", "by", "extensive", "atopic", "dermatitis", "lead", "to", "hypotonic", "dehydration", "electrolyte", "abnormalities", "hypoproteinemia", ",", "C0009447#ent", "<e1>", "and", ",", "finally", ",", "to", "C0015544#ent", "<e2>", "infants", "."], "h": {"id": "C0009447", "name": "C0009447#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0015544", "name": "C0015544#ent", "pos": [26, 27]}}
{"token": ["C0291772#ent", "<e1>", "is", "extensively", "metabolized", "by", "multiple", "cytochrome", "P450", "CYP", ")", "C3541394#ent", "<e2>", ",", "including", "CYP", "2C9", "and", "3A4", "."], "h": {"id": "C0291772", "name": "C0291772#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["C0291772#ent", "<e1>", "is", "extensively", "metabolized", "by", "multiple", "cytochrome", "P450", "CYP", ")", "C3541394#ent", "<e2>", ",", "including", "CYP2C9", "and", "CYP3A4", "."], "h": {"id": "C0291772", "name": "C0291772#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["Patients", "who", "received", "an", "C0027410#ent", "<e1>", "also", "less", "likely", "to", "drink", "heavily", "if", "they", "sampled", "C0001975#ent", "<e2>", "during", "treatment", "."], "h": {"id": "C0027410", "name": "C0027410#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [15, 16]}}
{"token": ["The", "effectiveness", "of", "the", "trocar", "technique", "catheter", "placement", "transvaginal", "sonographically", "drainage", "of", "C0030785#ent", "<e1>", "assessed", "in", "seven", "women", "who", "presented", "with", "C0030794#ent", "<e2>", "fever", ",", "and", "presumed", "C0030785#ent", "<e1>"], "h": {"id": "C0030785", "name": "C0030785#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030794", "name": "C0030794#ent", "pos": [21, 22]}}
{"token": ["These", "cultures", "were", "examined", "for", "dopamine", "sensitive", "C1382029#ent", "<e1>", "and", "specific", "ligand", "binding", "of", "C0037956#ent", "<e2>", "and", "[3H]flupenthixol", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037956", "name": "C0037956#ent", "pos": [14, 15]}}
{"token": ["A", "69-year-old", "woman", "with", "C0038013#ent", "<e1>", "RA", ")", "suffered", "two", "episodes", "of", "hyperkalemic", "C0085679#ent", "<e2>", "metabolic", "acidosis", "HCMA", ")", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085679", "name": "C0085679#ent", "pos": [13, 14]}}
{"token": ["To", "perform", "chromosomal", "mapping", "clinical", "analysis", "C0029899#ent", "<e1>", "to", "the", "fourth", "locus", "for", "otosclerosis", "(", "C1969046#ent", "<e2>", ")", "in", "an", "Israeli", "family"], "h": {"id": "C0029899", "name": "C0029899#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C1969046", "name": "C1969046#ent", "pos": [15, 16]}}
{"token": ["In", "areas", "where", "invasive", "organisms", "as", "Campylobacter", "and", "C0013371#ent", "<e1>", "are", "common", ",", "C0949665#ent", "<e2>", "remain", "the", "drug", "of", "choice", "."], "h": {"id": "C0013371", "name": "C0013371#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0949665", "name": "C0949665#ent", "pos": [13, 14]}}
{"token": ["The", "increase", "in", "gastric", "fluid", "pH", "was", "significantly", "greater", "for", "ranitidine", "(", "P", "<", "0.001", ")", "and", "C0600832#ent", "<e1>", "(", "P", "<", "0.02", ")", "than", "for", "C0003216#ent", "<e2>", "."], "h": {"id": "C0600832", "name": "C0600832#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003216", "name": "C0003216#ent", "pos": [26, 27]}}
{"token": ["A", "human", "cDNA", "probe", "then", "used", "to", "C1875400#ent", "<e1>", "the", "horse", "gonadotrophin", "alpha-subunit", "cDNA", "from", "the", "C0032002#ent", "<e2>", "and", "endometrial", "cup", "libraries", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [16, 17]}}
{"token": ["It", "is", "also", "the", "causal", "agent", "cases", "of", "bacillary", "angiomatosis", "C0243026#ent", "<e1>", ",", "endocarditis", "with", "negative", "blood", "cultures", "and", "C0149516#ent", "<e2>", "particularly", "in", "immunosuppressed", "patients", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0149516", "name": "C0149516#ent", "pos": [19, 20]}}
{"token": ["C1421527#ent", "<e1>", "YB-1", ")", "is", "a", "C0536221#ent", "<e2>", "can", "act", "as", "a", "regulator", "of", "transcription", "and", "of", "translation", "."], "h": {"id": "C1421527", "name": "C1421527#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [6, 7]}}
{"token": ["This", "study", "examined", "whether", "major", "changes", "in", "brain", "C3887648#ent", "<e1>", "concentrations", "can", "alter", "outcome", "from", "severe", "C0917798#ent", "<e2>"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [16, 17]}}
{"token": ["Shc", "binding", "C1704842#ent", "<e1>", "leads", "to", "activation", "of", "Ras", ",", "C1706586#ent", "<e2>", ",", "and", "MEK", "."], "h": {"id": "C1704842", "name": "C1704842#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [10, 11]}}
{"token": ["Silencing", "of", "a", "target", "gene", "encoding", "C0071009#ent", "<e1>", "highly", "effective", "24", "h", "after", "application", "of", "C0011777#ent", "<e2>", "."], "h": {"id": "C0071009", "name": "C0071009#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [15, 16]}}
{"token": ["In", "this", "report", ",", "three", "Bacillus", "extracellular", "hydrolytic", "enzymes", ",", "i.e.", ",", "C0002245#ent", "<e1>", ",", "mannanase", "and", "C0008145#ent", "<e2>", ",", "were", "cloned", "and", "over-expressed", "in", "Gram-negative", "Escherichia", "coli"], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008145", "name": "C0008145#ent", "pos": [17, 18]}}
{"token": ["This", "confirms", "the", "proposal", "that", "the", "C0027203#ent", "<e1>", "reacts", "with", "C0033046#ent", "<e2>", "before", "reacting", "with", "substrate", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033046", "name": "C0033046#ent", "pos": [10, 11]}}
{"token": ["Quantitatively", ",", "the", "Class", "Pi", "isoenzyme(s", ")", "predominated", "in", "all", "skin", "samples", "and", "the", "amount", "of", "C0027203#ent", "<e1>", "was", "about", "1", "-", "3", "micrograms", "GST", "Pi/mg", "C0033046#ent", "<e2>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0033046", "name": "C0033046#ent", "pos": [26, 27]}}
{"token": ["C0041912#ent", "<e1>", "mucositis", "and", "C0019360#ent", "<e2>", "stated", "in", "43", ",", "24", "and", "22", "%", "of", "the", "patients", "respectively", "."], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019360", "name": "C0019360#ent", "pos": [4, 5]}}
{"token": ["C0003385#ent", "<e1>", "vigorous", "gastric", "rhythms", "the", "isolated", "C1422277#ent", "<e2>", "."], "h": {"id": "C0003385", "name": "C0003385#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422277", "name": "C1422277#ent", "pos": [7, 8]}}
{"token": ["Sequence", "analysis", "the", "fusion", "region", "the", "amplified", "cDNA", "fragment", "an", "in-frame", "joining", "of", "exon", "e5", "of", "the", "MLL", "gene", "position", "1931", "of", "the", "cDNA", "sequence", "the", "C2827461#ent", "<e1>", "giving", "rise", "to", "a", "new", "C3274692#ent", "<e2>", "transcript", "."], "h": {"id": "C2827461", "name": "C2827461#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3274692", "name": "C3274692#ent", "pos": [33, 34]}}
{"token": ["In", "contrast", ",", "C1412481#ent", "<e1>", "treatment", "of", "primary", "neurons", "decreased", "activation", "of", "C0380051#ent", "<e2>", "a", "kinase", "that", "interacts", "with", "another", "apoE", "receptor", "adaptor", "protein", "c-Jun", "N-terminal", "kinase-interacting", "protein"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [12, 13]}}
{"token": ["Over", "the", "years", ",", "C0029997#ent", "<e1>", "has", "distinguished", "itself", "clinically", "from", "other", "C0005064#ent", "<e2>", "by", "virtue", "of", "its", "excellent", "tolerance", "."], "h": {"id": "C0029997", "name": "C0029997#ent", "pos": [4, 5]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [12, 13]}}
{"token": ["It", "appears", "that", "C0029997#ent", "<e1>", "is", "less", "likely", "than", "other", "C0005064#ent", "<e2>", "to", "induce", "dependence", "."], "h": {"id": "C0029997", "name": "C0029997#ent", "pos": [3, 4]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [10, 11]}}
{"token": ["The", "inactivation", "of", "C3659502#ent", "<e1>", "pseudo-first-order", "kinetics", ",", "whereas", "C2604870#ent", "<e2>", "a", "more", "complex", "behavior", "consistent", "with", "protein", "modification", "."], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2604870", "name": "C2604870#ent", "pos": [9, 10]}}
{"token": ["Aldose", "reductase", "AR", ";", "C3659502#ent", "<e1>", "is", "an", "oxidoreductase", "that", "catalyzes", "the", "C2604870#ent", "<e2>", "conversion", "of", "glucose", "to", "sorbitol", ",", "the", "first", "step", "of", "the", "polyol", "pathway"], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2604870", "name": "C2604870#ent", "pos": [12, 13]}}
{"token": ["From", "a", "comparison", "of", "the", "predicted", "C0079941#ent", "<e1>", "the", "GenBank", "protein", "database", "was", "concluded", "that", "C2348110#ent", "<e2>", "was", "a", "novel", "transcript", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2348110", "name": "C2348110#ent", "pos": [15, 16]}}
{"token": ["In", "the", "patients", "with", "C0011860#ent", "<e1>", "abnormal", "capillary", "pattern", "particularly", "common", "in", "patients", "with", "evidence", "of", "C0003838#ent", "<e2>"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003838", "name": "C0003838#ent", "pos": [16, 17]}}
{"token": ["In", "tolerance", "assay", "at", "42", "h", "after", "the", "end", "of", "conditioning", "regimen", "shorter", "preconvulsive", "latencies", "than", "in", "healthy", "(", "C0011279#ent", "<e1>", "conditioned", ")", "mice", "following", "C0022209#ent", "<e2>", "(", "800", "mg/kg", "i.p", ".", ")", "("], "h": {"id": "C0011279", "name": "C0011279#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022209", "name": "C0022209#ent", "pos": [25, 26]}}
{"token": ["In", "addition", "to", "lowering", "basal", "blood", "pressure", "BP", ")", ",", "angiotensin", "receptor", "blockers", "C0074722#ent", "<e1>", ")", "may", "benefit", "C0524620#ent", "<e2>", "patients", "by", "reducing", "oxidative", "stress", "arterial", "stiffness", "and", "pressor", "responses", "to", "exercise", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [18, 19]}}
{"token": ["Taken", "together", "with", "the", "recently", "reported", "functional", "interplay", "between", "adiponectin", "and", "angiotensin", "II", "this", "suggests", "that", "adiponectin", "probably", "mediates", "tissue-protective", "effects", "of", "C0074722#ent", "<e1>", "in", "obesity", "and", "C0524620#ent", "<e2>"], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [27, 28]}}
{"token": ["We", "detected", "virion-associated", "proteins", "to", "RT-integrase", "(", "IN", ")", "(", "pr98", ")", "and", "RT", "(", "C1333723#ent", "<e1>", ")", "as", "well", "as", "smaller", "proteins", "containing", "the", "C1335439#ent", "<e2>", "(", "p49", ")", "or", "RNase", "H", "domains"], "h": {"id": "C1333723", "name": "C1333723#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [25, 26]}}
{"token": ["Verapamil", "significantly", "reduced", "the", "L-glutamate-induced", "release", "of", "[3H]-ACh", "and", "the", "inhibitory", "effect", "of", "C0280858#ent", "<e1>", "was", "more", "pronounced", "in", "the", "presence", "of", "C1417500#ent", "<e2>", "+", "in", "the", "medium", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [22, 23]}}
{"token": ["The", "same", "tendency", "was", "found", "as", "for", "the", "modification", "of", "C0280858#ent", "<e1>", "effect", "by", "acetate", "in", "mitochondrial", "Ca2", "and", "C1417500#ent", "<e2>", "+", "accumulation", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [19, 20]}}
{"token": ["Whereas", "C0280858#ent", "<e1>", "and", "Cd2+", "ineffective", ",", "both", "C1417500#ent", "<e2>", "+", "and", "trace", "metals", "e.g.", "Fe", "and", "Zn", ",", "reverse", "the", "response", "to", "CT", "following", "injection", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [8, 9]}}
{"token": ["Farnesyl", "phosphonic", "acids", "potentiate", "the", "upregulation", "of", "these", "C0086376#ent", "<e1>", "induced", "by", "mevalonate", "depletion", "independent", "of", "inhibitory", "activity", "farnesyl", "protein", "transferase", "geranylgeranyl", "protein", "transferase", "I", "C3888279#ent", "<e2>", "or", "GGPP", "synthase"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3888279", "name": "C3888279#ent", "pos": [25, 26]}}
{"token": ["Anatoxin-a(s", ")", ",", "an", "alkaloid", "neurotoxin", "the", "freshwater", "cyanobacterium", ",", "Anabaena", "flos-aquae", "-", "17", ",", "was", "compared", "to", "C0052451#ent", "<e1>", ",", "physostigmine", "and", "C0034261#ent", "<e2>", "for", "effects", "on", "brain", "cholinesterase", "i.p", "."], "h": {"id": "C0052451", "name": "C0052451#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0034261", "name": "C0034261#ent", "pos": [23, 24]}}
{"token": ["After", "fluid", "restriction", "plasma", "AVP", "was", "uniformly", "normal", "relative", "to", "plasma", "osmolality", "patients", "with", "C1332124#ent", "<e1>", "primary", "polydipsia", "was", "distinctly", "subnormal", "in", "all", "patients", "with", "C0011848#ent", "<e2>"], "h": {"id": "C1332124", "name": "C1332124#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [25, 26]}}
{"token": ["It", "is", "a", "polydipsic-polyuric", "syndrome", "caused", "by", "partial", "or", "complete", "vasopressin", "deficiency", "central", "diabetes", "insipidus", "or", "vasopressin", "resistance", "the", "kidney", "tubules", "C1332124#ent", "<e1>", "or", "increased", "water", "intake", "to", "oversensitivity", "of", "the", "thirst", "centre", "C0011848#ent", "<e2>", "primary", "polydipsia", "."], "h": {"id": "C1332124", "name": "C1332124#ent", "pos": [21, 22]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [33, 34]}}
{"token": ["The", "plasma", "renin", "activity", "and", "response", "of", "blood", "pressure", "the", "angiotensin", "II", "analog", "a", "patient", "with", "C1332124#ent", "<e1>", "not", "significantly", "different", "from", "there", "of", "patients", "with", "C0011848#ent", "<e2>"], "h": {"id": "C1332124", "name": "C1332124#ent", "pos": [16, 17]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [26, 27]}}
{"token": ["The", "triazole", "antifungals", "C0016277#ent", "<e1>", "and", "itraconazole", ",", "are", "effective", "therapies", "for", "C0009186#ent", "<e2>", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [12, 13]}}
{"token": ["A", "large", "randomized", "trial", "that", "itraconazole", "and", "C0016277#ent", "<e1>", "had", "similar", "efficacies", "in", "the", "treatment", "of", "progressive", "C0009186#ent", "<e2>"], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [17, 18]}}
{"token": ["In", "previous", "open-label", "noncomparative", "clinical", "trials", ",", "both", "C0016277#ent", "<e1>", "and", "itraconazole", "were", "effective", "therapy", "for", "progressive", "forms", "of", "C0009186#ent", "<e2>", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [19, 20]}}
{"token": ["Escherichia", "coli", "thioesterase", "I", "TAP", ")", "is", "a", "multifunctional", "enzyme", "possessing", "activities", "of", "thioesterase", ",", "C0014894#ent", "<e1>", ",", "arylesterase", ",", "protease", ",", "and", "C0024361#ent", "<e2>", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0024361", "name": "C0024361#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "C1384553#ent", "<e1>", "is", "a", "C0033681#ent", "<e2>", "growth", "suppressing", "activity", "that", "may", "function", ",", "in", "part", ",", "through", "its", "interaction", "with", "pRb", "."], "h": {"id": "C1384553", "name": "C1384553#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [6, 7]}}
{"token": ["The", "fyn-related", "kinase", "C1384553#ent", "<e1>", ")", "belongs", "to", "the", "C0033681#ent", "<e2>"], "h": {"id": "C1384553", "name": "C1384553#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [9, 10]}}
{"token": ["Integrated", "HBV", "C0011519#ent", "<e1>", "from", "two", "single-integration", "HCCs", "(", "C3", "and", "C1412999#ent", "<e2>", ")", "have", "been", "cloned", ",", "and", "the", "cellular", "integration", "sites", "have", "been", "analyzed", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [11, 12]}}
{"token": ["We", "assessed", "the", "effects", "of", "epithelial", "removal", ",", "inhibitors", "of", "cyclooxygenases", ",", "C0132555#ent", "<e1>", "neutral", "endopeptidase", "antagonists", "of", "acetylcholine", ",", "histamine", ",", "C1537501#ent", "<e2>", "and", "tachykinin", "receptors"], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [22, 23]}}
{"token": ["No", "contribution", "of", "other", "C0132555#ent", "<e1>", "isoforms", "to", "either", "the", "action", "of", "C1537501#ent", "<e2>", "or", "the", "continuous", "ambient", "NO", "level", "could", "be", "detected", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [12, 13]}}
{"token": ["C0042251#ent", "<e1>", ",", "in", "many", "cases", ",", "C0036916#ent", "<e2>"], "h": {"id": "C0042251", "name": "C0042251#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [7, 8]}}
{"token": ["The", "results", "of", "the", "use", "of", "russian", "probiotics", "Acilact", "and", "C0053566#ent", "<e1>", "in", "complex", "treatment", "of", "C0017574#ent", "<e2>", "and", "different", "degrees", "of", "parodontitis", "are", "presented", "."], "h": {"id": "C0053566", "name": "C0053566#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017574", "name": "C0017574#ent", "pos": [16, 17]}}
{"token": ["Remarkably", ",", "the", "same", "C0080151#ent", "<e1>", "reported", "to", "alter", "C0379528#ent", "<e2>", "Alzheimer's", "disease", "reduce", "macrophage", "activation", "after", "platelet", "phagocytosis", "inhibit", "formation", "of", "Abeta-containing", "peptides", "."], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0379528", "name": "C0379528#ent", "pos": [9, 10]}}
{"token": ["However", ",", "acetylsalicylic", "acid", "naproxen", ",", "two", "C0080151#ent", "<e1>", "without", "effect", "on", "the", "C0379528#ent", "<e2>", "APP", ",", "did", "not", "affect", "nitrite", "production", "in", "either", "platelet-", "or", "LPS-stimulated", "macrophages", "."], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0379528", "name": "C0379528#ent", "pos": [13, 14]}}
{"token": ["Neutralization", "assays", "antisera", "to", "human", "interleukin-1", "alpha", "HuIL-1", "alpha", ",", "HuIL-1", "beta", "and", "HuIL-6", "revealed", "that", "cell-free", "TAF", "attributable", "mainly", "to", "C1522428#ent", "<e1>", "that", "IL-6", "augmented", "the", "C2346451#ent", "<e2>", "activity", "of", "C1522428#ent", "<e1>", "the", "culture", "supernatant"], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2346451", "name": "C2346451#ent", "pos": [27, 28]}}
{"token": ["Enhanced", "activity", "of", "matrix", "metalloproteinases", "C3494976#ent", "<e1>", ")", "has", "been", "associated", "with", "extracellular", "matrix", "degradation", "and", "C0018801#ent", "<e2>", "animal", "models", "human", "patients", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [16, 17]}}
{"token": ["The", "role", "of", "C3494976#ent", "<e1>", "in", "cardiac", "fibrosis", "the", "progression", "of", "C0018801#ent", "<e2>", "along", "with", "the", "possibility", "of", "halting", "the", "progression", "of", "C0018801#ent", "<e2>", "modulating", "extracellular", "matrix", "remodelling", "are", "important", "issues", "under", "intense", "study", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "injections", "of", "C0011689#ent", "<e1>", "melanocyte", "stimulating", "hormone", "(", "dMSH", ")", ",", "growth", "hormone", "and", "C1418938#ent", "<e2>", "are", "associated", "with", "increased", "food", "intake"], "h": {"id": "C0011689", "name": "C0011689#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [17, 18]}}
{"token": ["C0694884#ent", "<e1>", "is", "thus", "the", "expression", "of", "a", "C0919437#ent", "<e2>", "without", "available", "prevention", "or", "cure", "for", "malignancy", "."], "h": {"id": "C0694884", "name": "C0694884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919437", "name": "C0919437#ent", "pos": [8, 9]}}
{"token": ["Indeed", ",", "many", "clinical", "studies", "that", "salmeterol", "demonstrated", "better", "efficacy", "than", "long-acting", "beta(2)-agonist", "oral", "bronchodilators", ",", "theophyllines", ",", "and", "leukotriene-receptor", "antagonists", "C0004096#ent", "<e1>", "patients", "and", "C0242893#ent", "<e2>", "theophyllines", "in", "COPD", "patients", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [25, 26]}}
{"token": ["To", "relieve", "the", "C0004096#ent", "<e1>", "bronchodilators", "such", "as", "beta2-adrenoceptor", "agonists", "theophylline", "and", "C0242893#ent", "<e2>", "used", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [12, 13]}}
{"token": ["Although", "the", "inhalation", "of", "beta2-agonists", "has", "frequently", "been", "used", "to", "relieve", "C0004096#ent", "<e1>", ",", "the", "efficacy", "of", "C0242893#ent", "<e2>", "C0004096#ent", "<e1>", "still", "remains", "unclear", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [17, 18]}}
{"token": ["Consistent", "with", "results", "from", "the", "C0524823#ent", "<e1>", "Pim-1", "phosphorylates", "transfected", "C1420626#ent", "<e2>", "only", "on", "Thr(145", ")", "in", "p21-deficient", "human", "fibroblasts", "and", "this", "phosphorylation", "event", "results", "in", "the", "cytoplasmic", "localization", "C1420626#ent", "<e2>", "."], "h": {"id": "C0524823", "name": "C0524823#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [10, 11]}}
{"token": ["One", "child", "suffered", "from", "a", "moderate", "C0038450#ent", "<e1>", "due", "to", "a", "partial", "C0023075#ent", "<e2>", "one", "from", "some", "dyspnoea", "at", "function", "caused", "by", "broncho-pulmonary", "dysplasia"], "h": {"id": "C0038450", "name": "C0038450#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023075", "name": "C0023075#ent", "pos": [12, 13]}}
{"token": ["The", "CETP", "genotype", "exerted", "no", "consistent", "effects", "on", "baseline", "plasma", "lipoproteins", "and", "C1416804#ent", "<e1>", ",", "CETP", ",", "and", "C1455838#ent", "<e2>", "activities", "."], "h": {"id": "C1416804", "name": "C1416804#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1455838", "name": "C1455838#ent", "pos": [18, 19]}}
{"token": ["Serum", "triglycerides", "total", "cholesterol", "as", "well", "as", "the", "activities", "of", "hepatic", "lipase", "HL", ")", ",", "C1416804#ent", "<e1>", "LCAT", ")", "and", "C1455838#ent", "<e2>", "PLTP", ")", "and", "the", "concentration", "of", "lipopolysaccharide-binding", "protein", "LBP", ")", "were", "analyzed", "."], "h": {"id": "C1416804", "name": "C1416804#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1455838", "name": "C1455838#ent", "pos": [20, 21]}}
{"token": ["The", "integrity", "of", "the", "complex", "is", "destroyed", "by", "detergents", "and", "C0035542#ent", "<e1>", ";", "however", ",", "it", "is", "stable", "in", "C0013618#ent", "<e2>", "EDTA", ")", "which", "differentiates", "this", "structure", "from", "cellular", "polyribosomes"], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [19, 20]}}
{"token": ["All", "the", "preparations", "were", "shown", "to", "contain", "a", "C0035542#ent", "<e1>", "which", ",", "in", "the", "presence", "of", "C0013618#ent", "<e2>", "led", "to", "ribosome", "breakdown", "measured", "by", "the", "increase", "in", "acid-soluble", "nucleotides", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [16, 17]}}
{"token": ["However", ",", "the", "two", "C0035542#ent", "<e1>", "have", "similar", "specific", "activities", ",", "are", "inhibited", "by", "C0013618#ent", "<e2>", ",", "and", "have", "nearly", "identical", "substrate", "specificities", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [14, 15]}}
{"token": ["Another", "factor", "determining", "effectiveness", "of", "C1161352#ent", "<e1>", "penalization", "is", "the", "C0720099#ent", "<e2>", "of", "the", "effect", "of", "the", "C1161352#ent", "<e1>", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [10, 11]}}
{"token": ["The", "D(2", ")", "receptor", "antagonist", "C0038803#ent", "<e1>", "exerted", "synergistic", "and", "antagonistic", "effects", "C0022614#ent", "<e2>", "and", "SKF", "38393-triggered", "Fos", "production", ",", "in", "a", "region", "specific", "manner", "."], "h": {"id": "C0038803", "name": "C0038803#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [12, 13]}}
{"token": ["The", "sex-linked", "recessive", "gene", "C1705240#ent", "<e1>", "in", "the", "mouse", "produces", "a", "condition", "of", "testicular", "feminization", "C0039585#ent", "<e2>", "AIS", ")", "in", "hemizygotes", ",", "comparable", "to", "the", "condition", "of", "the", "same", "name", "in", "humans", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0039585", "name": "C0039585#ent", "pos": [15, 16]}}
{"token": ["The", "extent", "and", "nature", "of", "such", "activation", "in", "C0011860#ent", "<e1>", "patients", "who", "do", "not", "have", "C0021847#ent", "<e2>", "have", "not", "yet", "been", "addressed", "despite", "evidence", "relating", "sympathetic", "activation", "cardiovascular", "risk"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [15, 16]}}
{"token": ["The", "advanced", "stage", "C0011860#ent", "<e1>", "to", "several", "micro", "and", "macro", "vascular", "complications", "nephropathy", ",", "C0021847#ent", "<e2>", ",", "retinopathy", ",", "heart", "related", "problems", "etc", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [14, 15]}}
{"token": ["The", "steroid", "(", "oestradiol", ",", "progesterone", ",", "testosterone", ")", "and", "C0030956#ent", "<e1>", "(", "inhibins", ")", "hormones", "produced", "by", "the", "C0018050#ent", "<e2>", "regulate", "in", "turn", "hypothalamopituitary", "secretions", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [19, 20]}}
{"token": ["The", "risk", "factors", "predisposing", "to", "gallstone", "formation", "include", "obesity", ",", "diabetes", "mellitus", "C2936882#ent", "<e1>", "and", "pregnancy", ",", "hemolytic", "diseases", "and", "C0023890#ent", "<e2>", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [20, 21]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "clinical", "efficacy", "safety", "of", "artrofoon", "in", "C0003873#ent", "<e1>", "compared", "with", "C0012091#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [18, 19]}}
{"token": ["A", "35-year-old", "man", "with", "C0003873#ent", "<e1>", "selective", "IgA", "deficiency", "treatment", "with", "C0012091#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [11, 12]}}
{"token": ["Levetiracetam", ",", "remacemide", "and", "C0069751#ent", "<e1>", "have", "been", "used", "mainly", "for", "partial", "C0751495#ent", "<e2>", ":", "further", "studies", "of", "their", "roles", "in", "other", "circumstances", "are", "required", "."], "h": {"id": "C0069751", "name": "C0069751#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [12, 13]}}
{"token": ["C0069751#ent", "<e1>", "is", "an", "antiepileptic", "drug", "used", "to", "treat", "partial", "C0751495#ent", "<e2>", "in", "children", "and", "adults", "."], "h": {"id": "C0069751", "name": "C0069751#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [10, 11]}}
{"token": ["This", "study", "compared", "immediate", "(", "overnight", ")", "and", "progressive", "switching", "to", "C0069751#ent", "<e1>", "monotherapy", "in", "patients", "with", "partial", "C0751495#ent", "<e2>", "unsatisfactorily", "treated", "with", "carbamazepine", "monotherapy", "."], "h": {"id": "C0069751", "name": "C0069751#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [18, 19]}}
{"token": ["The", "activities", "of", "the", "C0034861#ent", "<e1>", "expressed", "in", "Escherichia", "coli", "not", "affected", "by", "capsaicin", ",", "C0059438#ent", "<e2>", ",", "and", "other", "ENOX2-inhibiting", "substances", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059438", "name": "C0059438#ent", "pos": [15, 16]}}
{"token": ["By", "contrast", ",", "the", "O-glycans", "linked", "to", "C0077918#ent", "<e1>", "include", "unusual", "core", "2", "type", "C0032594#ent", "<e2>", "terminated", "with", "one", ",", "two", ",", "or", "three", "sialyl", "Lewis(x)", "."], "h": {"id": "C0077918", "name": "C0077918#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [14, 15]}}
{"token": ["In", "a", "retrospective", "study", "80", "episodes", "of", "C0041466#ent", "<e1>", "salmonella", "(", "NTS", ")", "C0004610#ent", "<e2>", "in", "children", "were", "compared", "with", "55", "episodes", "in", "adults", "over", "a", "10-year", "period", "."], "h": {"id": "C0041466", "name": "C0041466#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [13, 14]}}
{"token": ["Salmonella", "typhi", "a", "flagellated", ",", "gram-negative", "bacillus", "to", "the", "family", "Enterobacteriaceae", "for", "C0041466#ent", "<e1>", "which", "is", "a", "prolonged", "C0004610#ent", "<e2>", ",", "systemic", "illness", "minimal", ",", "at", "least", "initially", ",", "diarrhoea", "."], "h": {"id": "C0041466", "name": "C0041466#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [18, 19]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "examine", "whether", "the", "C0001644#ent", "<e1>", "isoproterenol", ",", "increases", "plasma", "renin", "activity", "C3274822#ent", "<e2>", ")", "by", "activation", "of", "intrarenal", "or", "extrarenal", "pathways"], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "labetalol", ",", "an", "alpha-", "and", "C0001644#ent", "<e1>", "blocking", "drug", ",", "on", "blood", "pressure", "heart", "rate", "plasma", "renin", "activity", "C3274822#ent", "<e2>", ")", "and", "plasma", "aldosterone", "studied", "in", "17", "adult", "patients", "with", "essential", "hypertension"], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [21, 22]}}
{"token": ["A", "C0017337#ent", "<e1>", "encoding", "an", "C0109060#ent", "<e2>", "in", "Pseudomonas", "putida", "5B", "been", "cloned", ",", "sequenced", ",", "and", "overexpressed", "in", "Escherichia", "coli"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0109060", "name": "C0109060#ent", "pos": [5, 6]}}
{"token": ["Point", "mutations", "the", "C0017337#ent", "<e1>", "(", "Asah1", ")", "encoding", "one", "C0109060#ent", "<e2>", ",", "acid", "ceramidase", "AC", ")", ",", "lead", "to", "the", "lysosomal", "storage", "disorder", "Farber", "disease", "FD", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0109060", "name": "C0109060#ent", "pos": [10, 11]}}
{"token": ["The", "MEDAL", "program", "of", "3", "multinational", ",", "randomized", ",", "double-blind", "trials", "patients", "with", "osteoarthritis", "and", "C0038013#ent", "<e1>", "etoricoxib", "(", "60", "or", "90", "mg", "daily", ")", "to", "C0700583#ent", "<e2>", "(", "150", "mg", "daily", ")", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [26, 27]}}
{"token": ["These", "findings", "suggest", "that", "C1334507#ent", "<e1>", "may", "act", "as", "a", "mediator", "sustaining", "the", "pulmonary", "inflammatory", "response", "C0035222#ent", "<e2>", "and", "that", "an", "anti-MIF", "strategy", "may", "represent", "a", "novel", "therapeutic", "approach", "inflammatory", "diseases", "as", "C0035222#ent", "<e2>", "."], "h": {"id": "C1334507", "name": "C1334507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [16, 17]}}
{"token": ["The", "critical", "role", "of", "C1334507#ent", "<e1>", "MIF", ")", "in", "mediating", "inflammatory", "lung", "injury", "acute", "respiratory", "distress", "syndrome", "C0035222#ent", "<e2>", ")", "has", "been", "raised", "recently", "."], "h": {"id": "C1334507", "name": "C1334507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [17, 18]}}
{"token": ["The", "new", "agents", ",", "fluconazole", ",", "itraconazole", ",", "and", "C0771029#ent", "<e1>", ",", "have", "definitely", "improved", "the", "treatment", "of", "C4082762#ent", "<e2>"], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4082762", "name": "C4082762#ent", "pos": [18, 19]}}
{"token": ["Our", "results", "suggest", "that", "LPS", "and", "TNF-alpha-induced", "C1332415#ent", "<e1>", "expression", "was", "regulated", "by", "calmodulin", "(", "C1861821#ent", "<e2>", ")", "through", "the", "activation", "of", "calmodulin-dependent", "protein", "kinase-II", "CaMKII", ")", "."], "h": {"id": "C1332415", "name": "C1332415#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1861821", "name": "C1861821#ent", "pos": [15, 16]}}
{"token": ["Ruling", "out", "C0341268#ent", "<e1>", "such", "as", "C0010346#ent", "<e2>", "IBD", ")", ",", "is", "an", "important", "goal", "in", "the", "management", "of", "abdominal", "complaints"], "h": {"id": "C0341268", "name": "C0341268#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [6, 7]}}
{"token": ["APC11", "and", "C1710517#ent", "<e1>", "are", "also", "able", "to", "ubiquitinate", "securin", "and", "C1332695#ent", "<e2>", "but", "these", "reactions", "show", "a", "decreased", "dependency", "on", "the", "destruction", "box"], "h": {"id": "C1710517", "name": "C1710517#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332695", "name": "C1332695#ent", "pos": [11, 12]}}
{"token": ["We", "find", "that", "C1710517#ent", "<e1>", "and", "at", "least", "one", "other", "ubiquitin-conjugating", "enzyme", "support", "C1332695#ent", "<e2>", "ubiquitination", "."], "h": {"id": "C1710517", "name": "C1710517#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332695", "name": "C1332695#ent", "pos": [13, 14]}}
{"token": ["Both", "patients", "presented", "with", "intense", "C0030193#ent", "<e1>", "but", "the", "first", "patient", "also", "had", "C0000737#ent", "<e2>", "guarding", ",", "hematochezia", ",", "and", "leucocytosis", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [13, 14]}}
{"token": ["When", "colic", "was", "C0030193#ent", "<e1>", ",", "jejunal", "spasms", "the", "crisis", "of", "intense", "C0000737#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [12, 13]}}
{"token": ["A", "27-year-old", "male", "with", "ileo-anal", "pouch", "surgery", "presented", "with", "worsening", "C0030193#ent", "<e1>", "diarrhea", ",", "and", "C0000737#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [15, 16]}}
{"token": ["Ten", "patients", "with", "urticarial", "vasculitis", "characterized", "clinically", "by", "persistent", "C0030193#ent", "<e1>", "urticarial", "lesions", "angioedema", ",", "recurrent", "arthralgia", ",", "C0000737#ent", "<e2>", "and", "low-grade", "fever", "were", "selected", "for", "study", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [18, 19]}}
{"token": ["Based", "on", "1H", "intermolecular", "nuclear", "Overhauser", "effects", "(", "NOEs", ")", ",", "the", "C4082270#ent", "<e1>", "rings", "of", "all", "C1955902#ent", "<e2>", "studied", "reside", "near", "the", "polar", "interfacial", "head", "group", "region", "of", "the", "DMPC", "."], "h": {"id": "C4082270", "name": "C4082270#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1955902", "name": "C1955902#ent", "pos": [17, 18]}}
{"token": ["These", "have", "contributed", "to", "the", "rising", "iatrogenic", "problems", "of", "hepatitis", "C", "C0497169#ent", "<e1>", "and", "several", "other", "C0042769#ent", "<e2>"], "h": {"id": "C0497169", "name": "C0497169#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "evaluate", "the", "role", "of", "an", "inducible", "form", "of", "C1538973#ent", "<e1>", "iNOS", ")", "and", "OFR", "production", "in", "LPS-induced", "C1565662#ent", "<e2>"], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [25, 26]}}
{"token": ["Infrared", ",", "Raman", "and", "C1337112#ent", "<e1>", "spectra", "of", "picolinic", "acid", "N-oxide", "(", "C3890505#ent", "<e2>", ")", "were", "recorded", "and", "examined", "for", "the", "location", "of", "the", "hydronic", "modes", ",", "particularly", "O-H", "stretching", "COH", "bending", "."], "h": {"id": "C1337112", "name": "C1337112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890505", "name": "C3890505#ent", "pos": [12, 13]}}
{"token": ["The", "inhibitory", "effect", "of", "interleukin", "(IL)-10", "the", "accessory", "cell", "function", "C1860224#ent", "<e1>", "and", "the", "expression", "of", "C1366561#ent", "<e2>", "and", "CD86", "on", "C1860224#ent", "<e1>", "were", "also", "investigated", "."], "h": {"id": "C1860224", "name": "C1860224#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366561", "name": "C1366561#ent", "pos": [16, 17]}}
{"token": ["C1414427#ent", "<e1>", "rats", "were", "hyperresponsive", "to", "C0000096#ent", "<e2>", ",", "this", "agent", "inducing", "2.5-fold", "higher", "release", "than", "in", "untreated", "rats", "."], "h": {"id": "C1414427", "name": "C1414427#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000096", "name": "C0000096#ent", "pos": [6, 7]}}
{"token": ["Binding", "of", "C1706445#ent", "<e1>", "to", "the", "promoter", "inhibits", "C0011522#ent", "<e2>", "over", "a", "20", "base", "pair", "region", "upstream", "of", "the", "-45", "to", "+", "35", "region", "shown", "previously", "to", "interact", "with", "TFIID", "."], "h": {"id": "C1706445", "name": "C1706445#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "suggest", "that", "(", "1", ")", "C0879590#ent", "<e1>", "necessary", "for", "the", "growth", "of", "leukemic", "T-cells", "C0054871#ent", "<e2>", "tissue", "samples", "and", "(", "2", ")", "ATLV", "can", "infect", "not", "only", "T-cells", "but", "also", "B-cells", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [16, 17]}}
{"token": ["Nine", "cell", "lines", "ILT", "were", "C0879590#ent", "<e1>", "cell", "lines", "cloned", "from", "PBL", "of", "C0054871#ent", "<e2>", "patients", "and", "healthy", "HTLV-carriers", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "we", "observed", "in", "a", "hypothesis-generating", "exploratory", "search", "on", "the", "heritability", "of", "coronary", "morphology", "that", "left", "main", "coronary", "disease", "C1423769#ent", "<e1>", ")", "was", "frequently", "shared", "by", "siblings", "with", "C1956346#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C1423769", "name": "C1423769#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [29, 30]}}
{"token": ["Neogenesis", ",", "while", "increased", "with", "obesity", ",", "was", "comparable", "in", "obese", "type", "2", "diabetic", "C1708411#ent", "<e1>", ",", "or", "nondiabetic", "subjects", "and", "in", "C0011860#ent", "<e2>", "nondiabetic", "subjects", "."], "h": {"id": "C1708411", "name": "C1708411#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [22, 23]}}
{"token": ["This", "study", "aims", "to", "determine", "and", "correlate", "leptin", "levels", "to", "anthropometric", "measures", "obesity", "in", "pre-diabetic", ",", "(", "C1708411#ent", "<e1>", "and", "IGT", ")", ",", "C0011860#ent", "<e2>", "normoglycaemic", "Saudis", "."], "h": {"id": "C1708411", "name": "C1708411#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [23, 24]}}
{"token": ["The", "possible", "background", "of", "these", "observations", "with", "respect", "to", "the", "attachment", "of", "the", "C4288527#ent", "<e1>", "locus", "to", "the", "immunogenetic", "linkage", "group", "the", "major", "C0024518#ent", "<e2>", "on", "chromosome", "No.", "6", "man", "is", "discussed", "."], "h": {"id": "C4288527", "name": "C4288527#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [23, 24]}}
{"token": ["HSV-1", "also", "infects", "sensory", "neurons", "innervating", "the", "site", "of", "C1171315#ent", "<e1>", "establishes", "a", "C0872054#ent", "<e2>", "these", "cells", "."], "h": {"id": "C1171315", "name": "C1171315#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0872054", "name": "C0872054#ent", "pos": [13, 14]}}
{"token": ["Recent", "studies", "indicate", "the", "production", "of", "adrenocorticotropic", "hormone", "C1704793#ent", "<e1>", ")", "by", "human", "mononuclear", "leucocytes", "C0907533#ent", "<e2>", "or", "in", "response", "to", "hypothalamic", "factors", "interferon", "inducers"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [15, 16]}}
{"token": ["Mutations", "in", "the", "hepcidin", "gene", "HAMP", "and", "the", "C3810562#ent", "<e1>", "HJV", "have", "recently", "been", "shown", "to", "result", "in", "juvenile", "haemochromatosis", "C0268060#ent", "<e2>", ")", "."], "h": {"id": "C3810562", "name": "C3810562#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268060", "name": "C0268060#ent", "pos": [20, 21]}}
{"token": ["Mutations", "in", "the", "hepcidin", "gene", "HAMP", "and", "the", "C3810562#ent", "<e1>", "HJV", "have", "recently", "been", "shown", "to", "result", "in", "C0268060#ent", "<e2>", "JH", ")", "."], "h": {"id": "C3810562", "name": "C3810562#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268060", "name": "C0268060#ent", "pos": [18, 19]}}
{"token": ["Subsequently", ",", "I", "discovered", "that", "2", "forms", "of", "inherited", "C0019693#ent", "<e1>", "due", "to", "deficiencies", "of", "the", "enzymes", "adenosine", "deaminase", "C0034135#ent", "<e2>"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034135", "name": "C0034135#ent", "pos": [19, 20]}}
{"token": ["The", "method", "consists", "of", "extraction", "of", "C0002245#ent", "<e1>", "by", "boiling", "potassium", "hydroxide", "precipitation", "with", "ethanol", ",", "hydrolysis", "with", "C1161333#ent", "<e2>", "and", "determination", "of", "the", "C0002245#ent", "<e1>", "in", "form", "of", "glucose", "obtained", "with", "orthotoluidine", "."], "h": {"id": "C1161333", "name": "C1161333#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [6, 7]}}
{"token": ["The", "occurrence", "of", "consecutive", "C0015310#ent", "<e1>", "as", "a", "result", "of", "optical", "correction", "C0020490#ent", "<e2>", "has", "been", "documented", "infrequently", "in", "the", "ophthalmologic", "literature", "has", "rarely", "been", "mentioned", "in", "the", "optometric", "literature"], "h": {"id": "C0015310", "name": "C0015310#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020490", "name": "C0020490#ent", "pos": [12, 13]}}
{"token": ["The", "entire", "3.5", "kb", "C0022959#ent", "<e1>", "efficiently", "recombined", "into", "a", "target", "C0149678#ent", "<e2>", "vector", "lacking", "lacZ", "sequences", "but", "having", "limited", "homology", "to", "the", "donor", "plasmid"], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [11, 12]}}
{"token": ["Of", "these", "13", ",", "three", "were", "determined", "to", "have", "incubating", "syphilis", ";", "two", "had", "primary", "or", "C0149985#ent", "<e1>", "eight", "had", "C1260915#ent", "<e2>"], "h": {"id": "C0149985", "name": "C0149985#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1260915", "name": "C1260915#ent", "pos": [20, 21]}}
{"token": ["The", "captured", "Tp-IgM-RIA", "test", "with", "the", "purified", "antigen", "also", "undertaken", "in", "16", "patients", "with", "primary", "syphilis", "31", "patients", "with", "C0149985#ent", "<e1>", "73", "patients", "with", "C1260915#ent", "<e2>"], "h": {"id": "C0149985", "name": "C0149985#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1260915", "name": "C1260915#ent", "pos": [24, 25]}}
{"token": ["C1335278#ent", "<e1>", "(", "PTN", ")", "is", "an", "extracellular", "C1415033#ent", "<e2>", ",", "in", "post-natal", "life", ",", "is", "found", "mainly", "in", "bone", "and", "brain", "."], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415033", "name": "C1415033#ent", "pos": [8, 9]}}
{"token": ["C1335278#ent", "<e1>", "(", "PTN", ")", "is", "an", "18-kDa", "C1415033#ent", "<e2>", "different", "cell", "types"], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415033", "name": "C1415033#ent", "pos": [8, 9]}}
{"token": ["A", "tetrapyrrole", "binding", "assay", "recombinant", "proteins", "cHBP1", "and", "cHBP2", "revealed", "that", "both", "cHBPs", "bind", "to", "heme", ",", "C0072497#ent", "<e1>", "and", "Mg-protoporphyrin", "IX", "dimethyl", "ester", "distinct", "dissociation", "constants", "(", "C1839259#ent", "<e2>", ")", "of", "approximately", "submicro", "molar", "concentrations", "."], "h": {"id": "C0072497", "name": "C0072497#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [28, 29]}}
{"token": ["These", "shifts", "are", "consistent", "with", "affinity", "of", "C0056670#ent", "<e1>", "for", "beta3-adrenoceptors", "(", "estimated", "C1839576#ent", "<e2>", "values", "of", "7.27", "and", "7.38", "against", "isoprenaline", "and", "BRL", "37344", ",", "respectively", ")", "."], "h": {"id": "C0056670", "name": "C0056670#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [13, 14]}}
{"token": ["C0669372#ent", "<e1>", "NO", ")", "synthase", "(", "C1417760#ent", "<e2>", ")", ",", "interleukin-12", "(", "IL-12", ")", ",", "and", "interferon-gamma", "(IFN-gamma)-inducing", "factor", "IGIF", ")", "were", "transiently", "expressed", "in", "Meth", "A-M\u00f8s", "during", "the", "rejection", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [6, 7]}}
{"token": ["Elevated", "NO", "synthesis", "occurred", "in", "parallel", "with", "increased", "C0669372#ent", "<e1>", "C1417760#ent", "<e2>", ")", "enzyme", "activity", "mass", ",", "steady-state", "levels", "of", "C1417760#ent", "<e2>", "mRNA", ",", "increased", "transcription", "of", "the", "iNOS", "gene", "and", "increased", "C1417760#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [10, 11]}}
{"token": ["The", "differential", "diagnosis", ":", "bizarre", "periosteal", "osteochondromatous", "of", "the", "hands", "and", "feet", ",", "mature", "lesions", "of", "C0040798#ent", "<e1>", "osteogenic", "sarcoma", "confluent", "lesions", "of", "extra-articular", "synovial", "chondromatosis", "and", "nodular", "forms", "florid", "C0031111#ent", "<e2>", "."], "h": {"id": "C0040798", "name": "C0040798#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031111", "name": "C0031111#ent", "pos": [30, 31]}}
{"token": ["C1412122#ent", "<e1>", "activity", "at", "the", "developing", "C0751950#ent", "<e2>", "the", "occurrence", "of", "myofilaments", "preceded", "palatal", "closure", "several", "days", "."], "h": {"id": "C1412122", "name": "C1412122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [6, 7]}}
{"token": ["Despite", "the", "absence", "of", "myofibers", ",", "new", "C1412122#ent", "<e1>", "appeared", "in", "an", "arborized", "pattern", ",", "characteristic", "of", "C0751950#ent", "<e2>", "and", "its", "reaction", "product", "concentrated", "adjacent", "to", "the", "nerve", "terminals", "obscuring", "synaptic", "basal", "lamina", "."], "h": {"id": "C1412122", "name": "C1412122#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [17, 18]}}
{"token": ["Using", "pulse-chase", "analysis", "coupled", "with", "C0017976#ent", "<e1>", "we", "observed", "that", "C4048300#ent", "<e2>", "degradation", "occurs", "following", "complete", "maturation", "of", "the", "protein", "and", "that", "degradation", "was", "reversed", "by", "cysteine", "protease", "inhibitor", "E64", "not", "proteasome", "inhibitor", "."], "h": {"id": "C0017976", "name": "C0017976#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4048300", "name": "C4048300#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "a", "methanol", "extract", "C2699491#ent", "<e1>", "examined", "on", "C0038358#ent", "<e2>", "induced", "in", "rats", "by", "HCl/ethanol", "in", "order", "to", "substantiate", "its", "reputed", "protective", "properties"], "h": {"id": "C2699491", "name": "C2699491#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [10, 11]}}
{"token": ["This", "stimulation", "of", "morphological", "differentiation", "is", "accompanied", "by", "accumulation", "of", "C2986638#ent", "<e1>", "transcripts", "and", "production", "of", "C1540067#ent", "<e2>"], "h": {"id": "C2986638", "name": "C2986638#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1540067", "name": "C1540067#ent", "pos": [16, 17]}}
{"token": ["C2C12", "mouse", "myoblasts", "stably", "expressing", "FHL2", "show", "increased", "C2986638#ent", "<e1>", "differentiation", "reflected", "by", "accelerated", "myotube", "formation", "and", "expression", "of", "C1540067#ent", "<e2>"], "h": {"id": "C2986638", "name": "C2986638#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1540067", "name": "C1540067#ent", "pos": [19, 20]}}
{"token": ["A", "total", "of", "542", "C0018889#ent", "<e1>", "collected", "from", "104", "infected", "individuals", "was", "examined", "for", "glucose-6-phosphate", "dehydrogenase", "C1418516#ent", "<e2>", "using", "isoelectric", "focusing", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418516", "name": "C1418516#ent", "pos": [16, 17]}}
{"token": ["Mutation", "of", "a", "putative", "C1333571#ent", "<e1>", "(", "c-Jun", ")", "element", "suppressed", "c-Jun-mediated", "activation", "of", "the", "C1705637#ent", "<e2>", "promoter", "construct"], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705637", "name": "C1705637#ent", "pos": [15, 16]}}
{"token": ["Biochemical", "analysis", "that", "R.", "rubrum", "glutamine", "synthetase", "C0017787#ent", "<e1>", "NADP-dependent", ")", "but", "no", "detectable", "C0245866#ent", "<e2>"], "h": {"id": "C0017787", "name": "C0017787#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0245866", "name": "C0245866#ent", "pos": [14, 15]}}
{"token": ["The", "characterization", "of", "two", "human", "cDNAs", ",", "representing", "alternatively", "spliced", "mRNAs", ",", "provides", "insight", "into", "the", "unusual", "C0812382#ent", "<e1>", "and", "oligomerization", "properties", "of", "C3538776#ent", "<e2>", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3538776", "name": "C3538776#ent", "pos": [23, 24]}}
{"token": ["Analysis", "of", "clustered", "point", "mutants", "in", "the", "HIV-1", "leader", "for", "C0812382#ent", "<e1>", "and", "transcription", "activity", "in", "vitro", "in", "vivo", "a", "role", "for", "C3538776#ent", "<e2>", "as", "part", "of", "the", "basal", "promoter"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3538776", "name": "C3538776#ent", "pos": [22, 23]}}
{"token": ["RU-486", "and", "C1511755#ent", "<e1>", "together", "also", "produced", "significant", "accumulations", "of", "C0072497#ent", "<e2>", "."], "h": {"id": "C1511755", "name": "C1511755#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072497", "name": "C0072497#ent", "pos": [10, 11]}}
{"token": ["Similar", "to", "C0140145#ent", "<e1>", "Ref-1", ")", ",", "mRNA", "of", "human", "neuronal", "nitric", "oxide", "synthase", "C0907533#ent", "<e2>", ")", "was", "maximally", "up-regulated", "within", "2", "h", "after", "oxidative", "stress", "down-regulated", "by", "NO/GSNO", "and", "hydroxyl", "radical", "OH", ")", "scavenger", "."], "h": {"id": "C0140145", "name": "C0140145#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "whether", "C1306759#ent", "<e1>", "degranulation", "occurs", "in", "lesions", "of", "C0013595#ent", "<e2>", "we", "analyzed", "tissues", "by", "immunofluorescence", "for", "the", "presence", "of", "the", "eosinophil-granule", "major", "basic", "protein"], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [10, 11]}}
{"token": ["Intestinal", "mucosal", "barrier", "dysfunction", "observed", "in", "patients", "undergoing", "transperitoneal", "abdominal", "aortic", "aneurysm", "C1364818#ent", "<e1>", ")", "repair", "may", "contribute", "to", "the", "development", "of", "the", "C0242966#ent", "<e2>", "dysfunction", "of", "various", "organs", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242966", "name": "C0242966#ent", "pos": [23, 24]}}
{"token": ["Abdominal", "aortic", "aneurysm", "C1364818#ent", "<e1>", ")", "rupture", "is", "associated", "with", "C0242966#ent", "<e2>", "characterized", "by", "increased", "microvascular", "permeability", "neutrophil", "sequestration", ",", "leading", "to", "multiorgan", "dysfunction"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242966", "name": "C0242966#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "both", "wild-type", "and", "C1705628#ent", "<e1>", "binding-defective", "E7", "proteins", "abolish", "flat", "cell", "by", "C1706022#ent", "<e2>", "in", "SW13", "cells", ",", "whereas", "E7", "COOH-terminal", "mutants", "not", "affect", "this", "process", "."], "h": {"id": "C1705628", "name": "C1705628#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706022", "name": "C1706022#ent", "pos": [15, 16]}}
{"token": ["C1847791#ent", "<e1>", "is", "an", "oncogenic", "form", "the", "developmental", "regulator", "C1335192#ent", "<e2>", "transcription", "factor", "."], "h": {"id": "C1847791", "name": "C1847791#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335192", "name": "C1335192#ent", "pos": [9, 10]}}
{"token": ["In", "spite", "of", "the", "severity", "of", "C0026847#ent", "<e1>", "phenotype", "in", "mutant", "mice", "C1332801#ent", "<e2>", "is", "able", "to", "slow", "down", "disease", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332801", "name": "C1332801#ent", "pos": [12, 13]}}
{"token": ["Isoelectric", "focusing", "of", "C1415876#ent", "<e1>", "reveals", "a", "number", "of", ";", "C0022173#ent", "<e2>", "'", "."], "h": {"id": "C1415876", "name": "C1415876#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [10, 11]}}
{"token": ["SAPKK-4", "and", "SAPKK-5", "were", "also", "eluted", "from", "Mono", "S", "higher", "C1427213#ent", "<e1>", "concentrations", "than", "SAPKK-3", "and", "these", "C3541394#ent", "<e2>", "activated", "SAP", "kinase-1", "but", "not", "SAP", "kinase-2", "."], "h": {"id": "C1427213", "name": "C1427213#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["C1337050#ent", "<e1>", "contains", "the", "Swi2p/Snf2p", "like", "C0001473#ent", "<e2>", "BRG1", "or", "BRM", "exclusively", "."], "h": {"id": "C1337050", "name": "C1337050#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [6, 7]}}
{"token": ["This", "alteration", "can", "be", "accomplished", "with", "the", "help", "of", "chromatin-remodeling", "enzymes", "such", "as", "the", "various", "C1337050#ent", "<e1>", "classes", "of", "C0001473#ent", "<e2>", "."], "h": {"id": "C1337050", "name": "C1337050#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [19, 20]}}
{"token": ["There", "was", "a", "significant", "correlation", "between", "the", "incidence", "of", "C0007286#ent", "<e1>", "and", "the", "C2926735#ent", "<e2>", "of", "haemodialysis", "."], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [13, 14]}}
{"token": ["Further", ",", "it", "did", "not", "reverse", "the", "increase", "in", "C1419337#ent", "<e1>", "induced", "by", "an", "intravenous", "infusion", "C0006945#ent", "<e2>", "."], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [16, 17]}}
{"token": ["Small", "noncomparative", "studies", "C0246203#ent", "<e1>", "reduces", "LDL-C", "in", "patients", "with", "C0020443#ent", "<e2>", "secondary", "to", "kidney", "disorders", "<", "or", "=", "40.5", "%", "and", "with", "type", "2", "diabetes", "mellitus", "<", "or", "=", "32", "%", "."], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [10, 11]}}
{"token": ["The", "clinical", "efficacy", "tolerability", "of", "simvastatin", "and", "C0246203#ent", "<e1>", "were", "compared", "in", "432", "patients", "with", "C0020443#ent", "<e2>", "a", "multinational", ",", "randomised", ",", "double-blind", "trial"], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [15, 16]}}
{"token": ["The", "highest", "number", "was", "in", "the", "C0020676#ent", "<e1>", "rats", ",", "and", "the", "lowest", "was", "in", "the", "C0020550#ent", "<e2>", "rats", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [16, 17]}}
{"token": ["Baseline", "atrial", "rate", "Emax", "were", "significantly", "lower", "than", "normal", "in", "the", "C0020676#ent", "<e1>", "group", "and", "significantly", "higher", "normal", "in", "the", "C0020550#ent", "<e2>", "group", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [20, 21]}}
{"token": ["To", "explore", "the", "mechanism", ",", "the", "expression", "of", "TGFbetatype", "I", "II", "receptors", "ALK5", ",", "C1332012#ent", "<e1>", ",", "ALK3", ",", "ALK6", ",", "TGFbetaRII", ",", "BMPRII", ",", "C1704933#ent", "<e2>", "was", "studied", "."], "h": {"id": "C1332012", "name": "C1332012#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1704933", "name": "C1704933#ent", "pos": [25, 26]}}
{"token": ["C0002600#ent", "<e1>", "produced", "a", "clear", "impairment", "in", "the", "IA", "C0310298#ent", "<e2>", "."], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [9, 10]}}
{"token": ["In", "Experiment", "2", "it", "was", "evaluated", "whether", "C0002600#ent", "<e1>", "administered", "after", "the", "consolidation", "of", "this", "C0310298#ent", "<e2>", "would", "block", "the", "memory", "retrieval"], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [15, 16]}}
{"token": ["We", "present", "a", "report", "of", "a", "patient", "who", "had", "recently", "traveled", "in", "the", "Far", "East", "subsequently", "developed", "C0025229#ent", "<e1>", "by", "a", "fatal", "C0014038#ent", "<e2>", "."], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [22, 23]}}
{"token": ["C0025229#ent", "<e1>", "is", "a", "rare", "syndrome", "that", "may", "present", "as", "brain", "abscess", "C0014038#ent", "<e2>", "or", "meningoencephalitis", "."], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [12, 13]}}
{"token": ["When", "the", "effects", "of", "anti-asthmatic", "agents", "anti-IgE-induced", "mediator", "release", "these", "cells", "were", "compared", ",", "only", "the", "C0001644#ent", "<e1>", "phosphodiesterase", "inhibitors", "dose-dependent", "inhibition", "but", "not", "C0012694#ent", "<e2>", "or", "nedocromil", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [24, 25]}}
{"token": ["In", "summary", ",", "the", "renal", "tubular", "effects", "of", "dopamine", "on", "C0001492#ent", "<e1>", "Na+,K(+)-ATPase", "activity", "change", "during", "postnatal", "development", "a", "C1332691#ent", "<e2>", "manner", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [19, 20]}}
{"token": ["Placental", "vascular", "growth", "factors", "placental", "growth", "factor", "C3537355#ent", "<e1>", ")", ",", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "and", "its", "receptor", "(", "C1705150#ent", "<e2>", ")", ",", "are", "involved", "in", "the", "mechanism", "of", "placental", "vascular", "development", "maternal", "endothelial", "function", "the", "pregnancy", "."], "h": {"id": "C3537355", "name": "C3537355#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705150", "name": "C1705150#ent", "pos": [21, 22]}}
{"token": ["We", "studied", "the", "impact", "of", "tumorigenic", "C0032870#ent", "<e1>", "key", "regulators", "of", "C1539078#ent", "<e2>"], "h": {"id": "C0032870", "name": "C0032870#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [11, 12]}}
{"token": ["Two", "dimensional", "electrophoresis", "that", "recombinant", "beta-secretase", "from", "S2betaSEC/GalT-ST", "cells", "had", "a", "lower", "isoelectric", "point", "to", "beta-secretase", "from", "control", "S2betaSEC", "cells", "(", "C1419718#ent", "<e1>", "only", "with", "C3811065#ent", "<e2>", "."], "h": {"id": "C1419718", "name": "C1419718#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3811065", "name": "C3811065#ent", "pos": [25, 26]}}
{"token": ["The", "increased", "clearance", "of", "C3536949#ent", "<e1>", "may", "arise", "from", "an", "obesity-related", "depression", "in", "C1366439#ent", "<e2>", "concentration", "(", "e.g.", ",", "for", "T", ",", "E2", ",", "delta", "5-diol", ",", "etc", ".", ")", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [13, 14]}}
{"token": ["Although", "metformin", "restores", "cyclic", "pituitary-", "gonadal", "function", "and", "improves", "fertility", ",", "it", "can", "decrease", "levels", "of", "C3536949#ent", "<e1>", "and", "LH", "and", "increase", "levels", "of", "C1366439#ent", "<e2>", "in", "women", "with", "PCOS", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [24, 25]}}
{"token": ["Natively", "unfolded", "C1420276#ent", "<e1>", "binds", "to", "various", "C0086376#ent", "<e2>", "and", "conformational", "changes", "to", "C1420276#ent", "<e1>", "misfolding", "may", "alter", "physiological", "interactions", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [2, 3]}}
{"token": ["The", "overexpression", "of", "Tsg101", "resulted", "in", "increased", "phosphorylation", "of", "the", "C1414313#ent", "<e1>", "downstream", "activation", "of", "C0169101#ent", "<e2>"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [15, 16]}}
{"token": ["Phosphoinositide", "3-kinase", "PI3K", ",", "tyrosine", "kinase", "the", "C1414313#ent", "<e1>", "EGFR", ")", ",", "and", "C0169101#ent", "<e2>", "MEK", ")", "inhibitors", "were", "also", "tested", "."], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [13, 14]}}
{"token": ["C0694883#ent", "<e1>", "immunoprecipitates", "from", "COS7", "cells", "transfected", "with", "C0694883#ent", "<e1>", "phosphorylated", "the", "GPR", "domains", "C1835916#ent", "<e1>", "and", "the", "related", "protein", "LGN", "but", "not", "the", "AGS3-TPR", "domain", "."], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1835916", "name": "C1835916#ent", "pos": [14, 15]}}
{"token": ["C1539803#ent", "<e1>", ",", "one", "of", "the", "two", "known", "C0011849#ent", "<e2>", "susceptibility", "genes", "the", "region", ",", "resides", "within", "Niddm1i3", ",", "while", "Tcf7l2", "maps", "outside", "all", "four", "loci", "."], "h": {"id": "C1539803", "name": "C1539803#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}}
{"token": ["Amino", "acid", "analysis", "Edman", "degradation", "C0030956#ent", "<e1>", "that", "the", "core", "protein", "DMP1-PG", "is", "the", "37-kDa", "fragment", "of", "C1414084#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414084", "name": "C1414084#ent", "pos": [17, 18]}}
{"token": ["Antiserum", "was", "raised", "against", "the", "C0030956#ent", "<e1>", "from", "rat", "C1414084#ent", "<e2>", ",", "and", "the", "localization", "of", "C1414084#ent", "<e2>", "was", "examined", "by", "immunohistochemistry", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414084", "name": "C1414084#ent", "pos": [9, 10]}}
{"token": ["An", "overview", "is", "given", "of", "the", "pharmacokinetics", "of", "the", "currently", "available", "benzodiazepine", "hypnotics", "emphasis", "on", "C0039468#ent", "<e1>", "and", "other", "C0005064#ent", "<e2>"], "h": {"id": "C0039468", "name": "C0039468#ent", "pos": [15, 16]}, "relation": "has_structural_class", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [19, 20]}}
{"token": ["These", "data", "suggest", "that", ",", "during", "experimental", "sepsis", "gammadelta", "T", "cell-derived", "C1825592#ent", "<e1>", "promotes", "high", "levels", "of", "proinflammatory", "mediators", "C0004610#ent", "<e2>", ",", "resulting", "in", "enhanced", "lethality", "."], "h": {"id": "C1825592", "name": "C1825592#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [19, 20]}}
{"token": ["In", "a", "group", "of", "4684", "ex-Far-East", "prisoners", "of", "war", "released", "in", "1945", ",", "679", "had", "neurological", "disease", "C0029124#ent", "<e1>", "peripheral", "neuropathy", "the", "most", "common", "C0679247#ent", "<e2>", "."], "h": {"id": "C0029124", "name": "C0029124#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0679247", "name": "C0679247#ent", "pos": [24, 25]}}
{"token": ["Although", "initial", "transplant", "related", "mortality", "was", "low", "for", "C0003873#ent", "<e1>", "somewhat", "higher", "rates", "for", "C3714757#ent", "<e2>", "systemic", "lupus", "erythematosus", "and", "systemic", "sclerosis", "be", "falling", "with", "modifications", "in", "the", "stem", "cell", "transplantation", "regimens", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [14, 15]}}
{"token": ["Nevertheless", ",", "the", "etiology", "of", "these", "RFs", "and", "the", "precise", "role", "they", "play", "in", "the", "pathogenesis", "of", "C0003873#ent", "<e1>", "RA", ")", "and", "juvenile", "rheumatoid", "arthritis", "C3714757#ent", "<e2>", ")", "remain", "a", "major", "interest", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [25, 26]}}
{"token": ["Diagnosis", "is", "complicated", "as", "there", "are", "no", "specific", "clinical", "signs", "therefore", ",", "this", "C0039082#ent", "<e1>", "may", "be", "confused", "with", "other", "pathologies", "like", "acute", "fatty", "liver", "of", "pregnancy", "idiopathic", "thrombocytopenia", "C1268936#ent", "<e2>", "appendicitis", ",", "and", "etc", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C1268936", "name": "C1268936#ent", "pos": [29, 30]}}
{"token": ["C0039082#ent", "<e1>", "to", "this", "genus", "include", "C1268936#ent", "<e2>", "burn-associated", "sepsis", ",", "and", "a", "variety", "of", "respiratory", "tract", "infections", "including", "epiglottitis", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C1268936", "name": "C1268936#ent", "pos": [6, 7]}}
{"token": ["Indirect", "immunofluorescence", "confocal", "microscopy", "showed", "that", "C1422666#ent", "<e1>", "colocalized", "with", "glial", "fibrillary", "acidic", "protein", "indicating", "that", "C3539717#ent", "<e2>", "is", "expressed", "in", "astrocytes", "."], "h": {"id": "C1422666", "name": "C1422666#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539717", "name": "C3539717#ent", "pos": [16, 17]}}
{"token": ["These", "genetic", "and", "biochemical", "interactions", "between", "Tup1-Ssn6", "and", "C1414260#ent", "<e1>", "indicate", "that", "the", "capping", "enzyme", "associated", "with", "C0035679#ent", "<e2>", "a", "target", "of", "the", "corepressor", "complex"], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [17, 18]}}
{"token": ["We", "have", "developed", "adult", "mice", "carrying", "the", "Gaucher", "disease", "point", "mutation", "in", "the", "C1414998#ent", "<e1>", "(", "Gba", ")", "gene", "and", "exhibiting", "a", "partial", "C0017923#ent", "<e2>"], "h": {"id": "C1414998", "name": "C1414998#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017923", "name": "C0017923#ent", "pos": [23, 24]}}
{"token": ["In", "addition", ",", "clinical", "studies", "C1508750#ent", "<e1>", "suggest", "that", "it", "may", "normalize", "bowel", "function", "blocking", "C0242937#ent", "<e2>", "abdominal", "laparotomy", "patients", "with", "opioid-related", "postoperative", "ileus", "."], "h": {"id": "C1508750", "name": "C1508750#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242937", "name": "C0242937#ent", "pos": [15, 16]}}
{"token": ["The", "mechanism", "of", "the", "C0265372#ent", "<e1>", "association", "of", "C0271623#ent", "<e2>", "anosmia", ",", "and", "choanal", "atresia", "though", "to", "be", "due", "to", "a", "single", "developmental", "field", "defect", "the", "region", "of", "the", "median", "forebrain", "and", "associated", "structures"], "h": {"id": "C0265372", "name": "C0265372#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [8, 9]}}
{"token": ["Liquid-phase", "competitive", "inhibition", "specificity", "studies", "of", "C1706005#ent", "<e1>", "and", "IgG", "anti-HS", "monoclonal", "antibodies", "little", "cross-reactivity", "with", "other", "C3536869#ent", "<e2>", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536869", "name": "C3536869#ent", "pos": [17, 18]}}
{"token": ["The", "positive", "inotropic", "and", "C0042402#ent", "<e1>", "actions", "of", "phosphodiesterase", "(", "C0031640#ent", "<e2>", ")", "inhibitor", "drugs", "may", "offer", "therapeutic", "alternatives", "beta-agonists", "in", "critically", "ill", "patients", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [10, 11]}}
{"token": ["This", "C1848862#ent", "<e1>", "was", "detected", "in", "115", "patients", "with", "cisterna", "magna", "C1710146#ent", "<e2>"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1710146", "name": "C1710146#ent", "pos": [11, 12]}}
{"token": ["These", "diseases", "show", "genetic", "heterogeneity", "both", "autosomic", "dominant", "and", "C0017361#ent", "<e1>", "inheritance", "and", "mutations", "in", "the", "SEPN1", ",", "C1419778#ent", "<e2>", ",", "ACTA1", ",", "TPM3", "genes", "have", "been", "reported", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419778", "name": "C1419778#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "the", "13", "C0017361#ent", "<e1>", "RYR1", "mutations", "were", "distributed", "evenly", "along", "the", "entire", "C1419778#ent", "<e2>", "were", "associated", "with", "wide", "range", "of", "clinico-pathological", "phenotypes", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419778", "name": "C1419778#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "nine", "families", "presenting", "with", "a", "C0017361#ent", "<e1>", "the", "disease", "and", "showing", "a", "quantitative", "defect", "C1419778#ent", "<e2>", "expression", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419778", "name": "C1419778#ent", "pos": [16, 17]}}
{"token": ["C0085693#ent", "<e1>", "AA", ")", "is", "still", "the", "most", "common", "C0001314#ent", "<e2>"], "h": {"id": "C0085693", "name": "C0085693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001314", "name": "C0001314#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "C1422031#ent", "<e1>", "associates", "with", "C1419330#ent", "<e2>", "in", "hair", "cell", "stereocilia", "and", "may", "help", "form", "or", "stabilize", "connections", "between", "the", "plasma", "membrane", "the", "filamentous", "actin", "."], "h": {"id": "C1422031", "name": "C1422031#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419330", "name": "C1419330#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "two", "small", "genes", "KCNE1", "and", "KCNE2", "(", "at", "the", "C1416563#ent", "<e1>", "and", "LQT6", "loci", ")", ",", "and", "the", "C1528301#ent", "<e2>", "encoding", "a", "kinase", "regulating", "KCNE1", "and", "SCN5A", "channels", ")", "were", "sequenced", "."], "h": {"id": "C1416563", "name": "C1416563#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1528301", "name": "C1528301#ent", "pos": [20, 21]}}
{"token": ["Detachment", "of", "Na", ",", "K-ATPase", "from", "the", "cytoskeleton", "at", "2-h", "C1705556#ent", "<e1>", "depletion", "was", "significantly", "less", "in", "C1333928#ent", "<e2>", "with", "transfectant", "control", "G", "cells", "not", "at", "4-h", "C1705556#ent", "<e1>", "depletion", "."], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["The", "category", "of", "complicated", "C0153257#ent", "<e1>", "clinical", "entities", "severe", "and", "persistent", "C0032285#ent", "<e2>", ",", "progressive", "primary", "coccidioidomycosis", "fibrocavitary", "coccidioidomycosis", "cavities", ",", "and", "empyema", ",", "a", "complication", "of", "a", "ruptured", "cavity"], "h": {"id": "C0153257", "name": "C0153257#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [11, 12]}}
{"token": ["We", "found", "that", "JNK1", "(", "C1883559#ent", "<e1>", "WT", ")", "mediated", "H(2)O(2)-induced", "C0080058#ent", "<e2>", "up-regulation", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [11, 12]}}
{"token": ["The", "prevalence", "of", "delta", "markers", "variable", "and", "generally", "low", "in", "C0276609#ent", "<e1>", "suggesting", "that", "in", "Italy", "self-limited", "forms", "of", "C0011226#ent", "<e2>", "sporadically", "or", "by", "limited", "outbreaks", "."], "h": {"id": "C0276609", "name": "C0276609#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011226", "name": "C0011226#ent", "pos": [19, 20]}}
{"token": ["Multiple", "open", "double-blind", "studies", "confirmed", "the", "efficacy", "of", "C0022625#ent", "<e1>", "in", "the", "treatment", "of", "C0040262#ent", "<e2>"], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0040262", "name": "C0040262#ent", "pos": [14, 15]}}
{"token": ["There", "are", "numerous", "causative", "agents", "C0009763#ent", "<e1>", "many", "of", "which", "are", "associated", "with", "C0442893#ent", "<e2>"], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [13, 14]}}
{"token": ["To", "screen", "the", "compounds", "that", "inhibit", "protein", "kinases", "we", "used", "an", "assay", "system", "which", "activities", "of", "C0010531#ent", "<e1>", "protein", "kinase", "C", "src", "family", "protein", "tyrosine", "kinases", "eukaryotic", "elongation", "factor", "2", "kinase", "simultaneously", "detected", "on", "a", "single", "gel", "the", "C1333199#ent", "<e2>"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333199", "name": "C1333199#ent", "pos": [38, 39]}}
{"token": ["The", "C3813590#ent", "<e1>", "in", "the", "nonessential", "region", "between", "C1332013#ent", "<e2>", "and", "ac", "."], "h": {"id": "C3813590", "name": "C3813590#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332013", "name": "C1332013#ent", "pos": [8, 9]}}
{"token": ["When", "a", "case", "of", "C0085655#ent", "<e1>", "is", "superimposed", "with", "C0041327#ent", "<e2>", "it", "should", "be", "remembered", "that", "RFP", "may", "shorten", "the", "half-life", "of", "any", "steroid", "or", "CyA", "that", "is", "administered", "as", "treatment", "."], "h": {"id": "C0085655", "name": "C0085655#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [9, 10]}}
{"token": ["The", "non-selective", "5-HT(2/7", ")", "receptor", "antagonist", "C0085260#ent", "<e1>", "and", "the", "selective", "C0360055#ent", "<e2>", "(R)-3-(2-(2-(4-methyl-piperidin-1-yl)-pyrrolidine-1-sulfonyl)-phenol", "(", "SB-269970-A", ")", "at", "0.5", "microg/side", "blocked", "all", "three", "receptor", "agonists", "injected", "concurrently", "into", "the", "zona", "incerta"], "h": {"id": "C0085260", "name": "C0085260#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0360055", "name": "C0360055#ent", "pos": [11, 12]}}
{"token": ["Treatment", "with", "C0006230#ent", "<e1>", ",", "amantadine", "and", "L-dops", "had", "no", "effect", "but", "the", "C0030567#ent", "<e2>", "dramatically", "improved", "with", "administration", "of", "L-dopa", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [13, 14]}}
{"token": ["C0006230#ent", "<e1>", "alters", "the", "motor", "behaviour", "animals", "and", "improves", "the", "motor", "defect", "C0030567#ent", "<e2>", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [12, 13]}}
{"token": ["C0030883#ent", "<e1>", ",", "biperiden", "and", "C0012010#ent", "<e2>", ",", "while", "depressing", "the", "arousal", "response", "caused", "an", "enhancement", "of", "the", "caudate", "spindle", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [5, 6]}}
{"token": ["Concentrations", "of", "C0030883#ent", "<e1>", ",", "and", "unbound", "and", "total", "C0012010#ent", "<e2>", "in", "serum", ",", "and", "ethanol", "in", "breath", "were", "quantified", ";", "as", "well", "as", "whole", "brain", "concentrations", "of", "C0012010#ent", "<e2>", "and", "N-demethyldiazepam", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [9, 10]}}
{"token": ["It", "potentiated", "the", "effect", "of", "a", "subprotective", "dose", "(", "5", "mg/kg", ")", "of", "C0030883#ent", "<e1>", ",", "but", "not", "of", "C0012010#ent", "<e2>", ",", "against", "tonic", "convulsions", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [19, 20]}}
{"token": ["The", "steady-state", "levels", "of", "hamster", "MHC", "class", "I", "mRNA", "and", "cell", "surface", "protein", "analysed", "in", "cells", "transformed", "by", "either", "adenovirus", "type", "12", "C1970209#ent", "<e1>", ")", "or", "types", "2", "or", "5", "(", "C2827465#ent", "<e2>", "or", "Ad5", ")", "."], "h": {"id": "C1970209", "name": "C1970209#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2827465", "name": "C2827465#ent", "pos": [31, 32]}}
{"token": ["These", "data", "suggest", "that", "alpha", "v-containing", "integrins", "alone", "may", "be", "sufficient", "to", "support", "infection", "by", "C1970209#ent", "<e1>", "and", "that", "this", "pathway", "is", "not", "efficiently", "used", "by", "C2827465#ent", "<e2>", "."], "h": {"id": "C1970209", "name": "C1970209#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2827465", "name": "C2827465#ent", "pos": [26, 27]}}
{"token": ["The", "response", "was", "also", "not", "affected", "by", "C0044305#ent", "<e1>", ",", "a", "potent", "C3850070#ent", "<e2>", "which", "suggests", "that", "this", "monooxygenase", "is", "not", "involved", "."], "h": {"id": "C0044305", "name": "C0044305#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3850070", "name": "C3850070#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "clonal", "expansion", "of", "some", "CSF", "B", "cells", "occur", "independently", "of", "C1367452#ent", "<e1>", ",", "but", "the", "C3889436#ent", "<e2>", "is", "governed", "by", "typical", "C1367452#ent", "<e1>", "selection", "."], "h": {"id": "C3889436", "name": "C3889436#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [12, 13]}}
{"token": ["A", "global", "increase", "in", "all", "myosin", "heavy", "chain", "C3814150#ent", "<e1>", ")", "mRNA", "isoforms", "was", "observed", "in", "C1705312#ent", "<e2>", "patients", "."], "h": {"id": "C3814150", "name": "C3814150#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705312", "name": "C1705312#ent", "pos": [16, 17]}}
{"token": ["The", "interaction", "of", "the", "C0032089#ent", "<e1>", "A", "with", "glycogen", "and", "C0017923#ent", "<e2>", "was", "studied", "."], "h": {"id": "C0032089", "name": "C0032089#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017923", "name": "C0017923#ent", "pos": [10, 11]}}
{"token": ["High", "activity", "C3539768#ent", "<e1>", "PLA2", ")", "has", "been", "detected", "in", "synovial", "fluids", "C1704887#ent", "<e2>", ")", "in", "inflammatory", "arthritides"], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704887", "name": "C1704887#ent", "pos": [12, 13]}}
{"token": ["A", "six-residue", "C1366529#ent", "<e1>", "signal", "is", "needed", "for", "activity", "in", "C3811250#ent", "<e2>", ",", "suggesting", "that", "an", "amino-terminal", "aromatic", "side", "chain", "is", "obligatory", "."], "h": {"id": "C1366529", "name": "C1366529#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3811250", "name": "C3811250#ent", "pos": [10, 11]}}
{"token": ["TGF-beta", "up-regulated", "PTPRK", "mRNA", "and", "C1452493#ent", "<e1>", "receptor", "type", "protein", "tyrosine", "phosphatase", "kappa", "the", "protein", "product", "encoded", "by", "the", "C1419117#ent", "<e2>", "protein", "in", "tumor", "and", "nontumor", "mammary", "cells", "HER2", "overexpression", "down-regulated", "its", "expression", "."], "h": {"id": "C1452493", "name": "C1452493#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419117", "name": "C1419117#ent", "pos": [19, 20]}}
{"token": ["Rabbit", "hearts", "were", "studied", "at", "different", "periods", "of", "experimental", "C0020538#ent", "<e1>", "its", "treatment", "with", "C0042523#ent", "<e2>", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [14, 15]}}
{"token": ["Heart", "rate", "arterial", "pressure", "patients", "with", "C0020538#ent", "<e1>", "treatment", "with", "C0042523#ent", "<e2>", "or", "propranolol", "were", "significant", "lower", "than", "before", "treatment", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [10, 11]}}
{"token": ["Finally", ",", "we", "found", "that", "expression", "of", "C1424637#ent", "<e1>", "induces", "a", "surprising", "reciprocal", "activation", "of", "C1412511#ent", "<e2>", ",", "which", "suggests", "that", "regulatory", "cross", "talk", "exists", "among", "Arf", "isoforms"], "h": {"id": "C1424637", "name": "C1424637#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412511", "name": "C1412511#ent", "pos": [15, 16]}}
{"token": ["We", "report", "the", "crystal", "structure", "the", "catalytic", "domain", "C1704928#ent", "<e1>", ",", "complexed", "to", "a", "variant", "of", "C0906802#ent", "<e2>", "."], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [16, 17]}}
{"token": ["Rottlerin", "blocked", "C1704928#ent", "<e1>", "activation", ",", "but", "the", "c-Abl", "inhibitor", "C0906802#ent", "<e2>", "increased", "MGO", "and", "cisplatin-induced", "apoptosis", "by", "50", "%", "."], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [10, 11]}}
{"token": ["Taken", "together", ",", "these", "results", "suggest", "that", "selective", "suppression", "of", "C1704928#ent", "<e1>", "activity", "by", "C0906802#ent", "<e2>", "may", "represent", "a", "potential", "anticancer", "strategy", "for", "p53-mutated", "undifferentiated", "thyroid", "carcinomas"], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [14, 15]}}
{"token": ["C0079941#ent", "<e1>", "YBL0718", "was", "identified", "as", "CDC27", ";", "YBL0706", "as", "C0919524#ent", "<e2>", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919524", "name": "C0919524#ent", "pos": [10, 11]}}
{"token": ["The", "rate", "of", "the", "oxygen-dependent", "reaction", "between", "calf", "thymus", "thioredoxin", "reductase", "GS-Se-SG", "was", "increased", "2-fold", "in", "the", "presence", "of", "4", "mM", "C1260386#ent", "<e1>", ",", "indicating", "that", "C3540642#ent", "<e2>", "was", "the", "reactive", "intermediate"], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3540642", "name": "C3540642#ent", "pos": [26, 27]}}
{"token": ["Thus", ",", "although", "isoflurane", "seemed", "to", "facilitate", "C0020452#ent", "<e1>", "with", "an", "increased", "O2", "supply", "to", "the", "brain", ",", "C0015846#ent", "<e2>", "tended", "to", "induce", "the", "opposite", "response", "."], "h": {"id": "C0020452", "name": "C0020452#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015846", "name": "C0015846#ent", "pos": [18, 19]}}
{"token": ["We", "report", "an", "African-American", "female", "with", "TRMA-syndrome", "associated", "with", "thyroid", "disease", "C0035334#ent", "<e1>", "by", "a", "novel", "mutation", "in", "the", "C1420118#ent", "<e2>"], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420118", "name": "C1420118#ent", "pos": [19, 20]}}
{"token": ["We", "determined", "the", "platelet", "count", "MPV", "in", "100", "normal", "subjects", "in", "147", "subjects", "with", "thrombocytopenia", "or", "C0836924#ent", "<e1>", "due", "to", "other", "than", "C0018939#ent", "<e2>", "and", "in", "smaller", "groups", "with", "immune", "or", "septic", "thrombocytopenia", "iron", "deficiency"], "h": {"id": "C0836924", "name": "C0836924#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [22, 23]}}
{"token": ["The", "possible", "prothrombotic", "role", "of", "C0836924#ent", "<e1>", "and", "other", "C0018939#ent", "<e2>", "discussed", "."], "h": {"id": "C0836924", "name": "C0836924#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [9, 10]}}
{"token": ["However", ",", "there", "were", "no", "significant", "between", "older", "patients", "with", "C1709289#ent", "<e1>", "and", "those", "with", "isolated", "C0221155#ent", "<e2>", "the", "level", "of", "SBP", ",", "vascular", "resistance", "stroke", "volume", ",", "and", "cardiac", "index"], "h": {"id": "C1709289", "name": "C1709289#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221155", "name": "C0221155#ent", "pos": [16, 17]}}
{"token": ["One", "criticism", "of", "the", "C2982405#ent", "<e1>", "scoring", "matrix", "that", "the", "frequency", "of", "C2917660#ent", "<e2>", "changes", "that", "require", "two", "nucleotide", "changes", "higher", "than", "would", "be", "expected", "by", "chance", "."], "h": {"id": "C2982405", "name": "C2982405#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [12, 13]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "assess", "whether", "serum", "levels", "of", "C2984583#ent", "<e1>", "PAPP-A", ")", "are", "elevated", "early", "in", "patients", "with", "acute", "myocardial", "infarction", "C0340293#ent", "<e2>", ")", "."], "h": {"id": "C2984583", "name": "C2984583#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [25, 26]}}
{"token": ["To", "avoid", "systemic", "toxicity", "of", "the", "cytotoxic", "drug", "methotrexate", "(", "C1417487#ent", "<e1>", ")", "and", "to", "improve", "tumor", "selectivity", "C1417487#ent", "<e1>", "was", "bound", "to", "human", "serum", "albumin", "C0393754#ent", "<e1>", ")", "as", "a", "drug", "carrier"], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [26, 27]}}
{"token": ["The", "binding", "of", "methotrexate", "(", "C1417487#ent", "<e1>", ")", "and", "citrovorum", "factor", "CF", ")", "to", "human", "serum", "albumin", "C0393754#ent", "<e2>", ")", "was", "investigated", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [17, 18]}}
{"token": ["Serum", "and", "ionized", "calcium", "levels", "C0745106#ent", "<e1>", "patients", "were", "higher", "than", "in", "normal", "subjects", "while", "C0020550#ent", "<e2>", "patients", "had", "levels", "only", "slightly", "higher", "than", "those", "in", "normal", "subjects"], "h": {"id": "C0745106", "name": "C0745106#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [15, 16]}}
{"token": ["The", "detection", "level", "of", "C1334043#ent", "<e1>", "100", "pg", "and", "C0024286#ent", "<e2>", "DNA", "was", "detectable", "in", "infected", "cells", "when", "total", "L2", "probe", "was", "used", "in", "the", "nucleic", "acid", "hybridization", "test"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024286", "name": "C0024286#ent", "pos": [9, 10]}}
{"token": ["We", "recently", "reported", "that", "inhibition", "of", "endogenous", "C0054846#ent", "<e1>", "CKII", ")", "protects", "target", "cells", "C0276275#ent", "<e2>", "CPE", ",", "pointing", "to", "this", "kinase", "as", "an", "effector", "of", "MVM", "toxicity", "."], "h": {"id": "C0054846", "name": "C0054846#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0276275", "name": "C0276275#ent", "pos": [14, 15]}}
{"token": ["The", "new", "aqueous", "formulation", "of", "C0040866#ent", "<e1>", "TAA", ")", "was", "compared", "with", "loratadine", "in", "patients", "with", "C0035457#ent", "<e2>"], "h": {"id": "C0040866", "name": "C0040866#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [16, 17]}}
{"token": ["Fifteen", "consecutive", "patients", "with", "a", "diagnostic", "problem", "ischaemia-induced", "migraine", "with", "aura", "(", "symptomatic", "C0149931#ent", "<e1>", ")", "or", "migraine-associated", "ischaemia", "(", "C1112466#ent", "<e2>", "were", "studied", "in", "order", "to", "elucidate", "the", "mechanisms", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C1112466", "name": "C1112466#ent", "pos": [20, 21]}}
{"token": ["If", "all", "7", "cases", "were", "considered", "C0149931#ent", "<e1>", ",", "the", "incidence", "rate", "first", "C1112466#ent", "<e2>", "3.36", "per", "100,000", "per", "year", "(", "95", "%", "confidence", "limits", "-", "5.86", ")", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C1112466", "name": "C1112466#ent", "pos": [13, 14]}}
{"token": ["Rat", "bone", "marrow", "cells", "cultured", "in", "C0964287#ent", "<e1>", "with", "10", "%", "fetal", "bovine", "serum", ",", "M-CSF", ",", "C1367028#ent", "<e2>", ",", "and", "1,25(OH)2D3", "for", "1", "week", "to", "promote", "osteoclast", "formation", "."], "h": {"id": "C0964287", "name": "C0964287#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1367028", "name": "C1367028#ent", "pos": [17, 18]}}
{"token": ["60", "out-patients", "with", "C0013295#ent", "<e1>", "treated", "in", "an", "open", "randomized", "trial", "2", "x", "150", "mg", "C0034665#ent", "<e2>", "or", "2", "x", "400", "mg", "cimetidine", ",", "respectively", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "C0007367#ent", "<e1>", ",", "the", "lipoxygenase", "inhibitor", "nordihydroguaiaretic", "acid", "the", "synthetic", "ROS", "scavenger", "C0969232#ent", "<e2>", ",", "and", "phosphatidylinositol", "3-kinase", "inhibitor", "wortmannin", "all", "reduce", "ERK", "phosphorylation", "in", "response", "to", "VEGF", ",", "and", "antioxidants", "prevent", "VEGF-dependent", "mitogenesis", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0969232", "name": "C0969232#ent", "pos": [14, 15]}}
{"token": ["Diabetic", "nephropathy", "which", "represents", "a", "major", "form", "of", "chronic", "kidney", "disease", "CKD", ")", ",", "is", "a", "leading", "cause", "of", "C2316810#ent", "<e1>", ",", "and", "is", "also", "a", "risk", "factor", "cardiovascular", "disease", "C0007222#ent", "<e2>", ")", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [30, 31]}}
{"token": ["Patients", "with", "C2316810#ent", "<e1>", "maintenance", "dialysis", "therapy", "a", "high", "prevalence", "of", "cardiovascular", "risk", "factors", "cardiovascular", "disease", "C0007222#ent", "<e2>", ")", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [16, 17]}}
{"token": ["The", "cytoplasmic", "helicase", "proteins", "RIG-I", "(", "retinoic-acid-inducible", "protein", "I", "also", "known", "as", "Ddx58", ")", "and", "C1537399#ent", "<e1>", "(", "melanoma-differentiation-associated", "gene", "5", "also", "known", "as", "Ifih1", "or", "C1310463#ent", "<e2>", ")", "have", "been", "implicated", "in", "viral", "dsRNA", "recognition", "."], "h": {"id": "C1537399", "name": "C1537399#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1310463", "name": "C1310463#ent", "pos": [26, 27]}}
{"token": ["The", "cytoplasmic", "helicase", "proteins", "RIG-I", "(", "retinoic-acid-inducible", "protein", "I", "also", "known", "as", "Ddx58", ")", "and", "MDA5", "(", "C1537399#ent", "<e1>", "also", "known", "as", "Ifih1", "or", "C1310463#ent", "<e2>", ")", "have", "been", "implicated", "in", "viral", "dsRNA", "recognition", "."], "h": {"id": "C1537399", "name": "C1537399#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1310463", "name": "C1310463#ent", "pos": [24, 25]}}
{"token": ["In", "the", "present", "report", ",", "a", "C1413396#ent", "<e1>", "ODC/HDC", "was", "used", "to", "elucidate", "whether", "the", "C0032064#ent", "<e2>", "region-containing", "C-termini", "of", "ODC", "and", "HDC", "are", "exchangeable", "."], "h": {"id": "C1413396", "name": "C1413396#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032064", "name": "C0032064#ent", "pos": [15, 16]}}
{"token": ["Functional", "quantification", "of", "C0086509#ent", "<e1>", "by", "a", "CPI", "(", "C1333188#ent", "<e2>", "assay", "showed", "no", "significant", "differences", "between", "the", "patients", "and", "the", "controls", "."], "h": {"id": "C0086509", "name": "C0086509#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333188", "name": "C1333188#ent", "pos": [9, 10]}}
{"token": ["Chicken", "cystatin", "human", "C0086509#ent", "<e1>", "members", "of", "the", "cystatin", "superfamily", "C1333188#ent", "<e2>"], "h": {"id": "C0086509", "name": "C0086509#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333188", "name": "C1333188#ent", "pos": [10, 11]}}
{"token": ["The", "deduced", "aa", "sequence", "of", "arawana", "C1364160#ent", "<e1>", "contains", "ten", "C2717970#ent", "<e2>", ",", "compared", "with", "11", "in", "teleost", "C1364160#ent", "<e1>", "and", "in", "mammalian", "STC-1", "."], "h": {"id": "C1364160", "name": "C1364160#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [10, 11]}}
{"token": ["14", "-", "3", "-", "3", "proteins", "bind", "to", "a", "diverse", "group", "of", "regulatory", "molecules", "as", "C0139905#ent", "<e1>", ",", "Cbl", ",", "and", "C0105421#ent", "<e2>", "that", "are", "involved", "in", "signal", "transduction", "pathways"], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [21, 22]}}
{"token": ["Using", "an", "inducible", "deletion", "system", "DT40", "cells", ",", "the", "contribution", "of", "C0139905#ent", "<e1>", "and", "B-Raf", "to", "C0105421#ent", "<e2>", "signalling", "was", "dissected", "."], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [16, 17]}}
{"token": ["Delusions", "of", "parasitosis", "is", "classically", "treated", "with", "C0040615#ent", "<e1>", "the", "traditional", "dermatologic", "choice", "C0031935#ent", "<e2>", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [13, 14]}}
{"token": ["Potent", "C0040615#ent", "<e1>", "e.g.", "haloperidol", "and", "C0031935#ent", "<e2>", ",", "are", "the", "most", "effective", "drugs", "but", "their", "limitations", "are", "their", "extrapyramidal", "side", "effects", "EPS", ")", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [6, 7]}}
{"token": ["The", "HDAg", "detection", "rate", "in", "chronic", "liver", "diseases", "severe", "C0019158#ent", "<e1>", "was", "higher", "than", "in", "other", "C0023895#ent", "<e2>"], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [16, 17]}}
{"token": ["A", "wide", "spectrum", "of", "hepatobiliary", "diseases", "been", "described", ",", "including", "asymptomatic", "elevations", "of", "liver", "enzyme", "levels", ",", "nonspecific", "C0019158#ent", "<e1>", ",", "nonalcoholic", "fatty", "liver", "disease", "and", "autoimmune", "and", "C0023895#ent", "<e2>"], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [28, 29]}}
{"token": ["In", "C0001492#ent", "<e1>", "forskolin-induced", "cAMP", "accumulation", "was", "inhibited", "by", "SRIF", "and", "C1710000#ent", "<e2>", ",", "thus", "confirming", "that", "the", "rAP6", "-", "26", "cDNA", "encodes", "a", "functional", "receptor", "protein"], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1710000", "name": "C1710000#ent", "pos": [11, 12]}}
{"token": ["C2919152#ent", "<e1>", "and", "3-carbethoxypsoralen", "produced", "1O2", "greater", "than", "C0033858#ent", "<e2>", "(", "angelicins", ")", "."], "h": {"id": "C2919152", "name": "C2919152#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0033858", "name": "C0033858#ent", "pos": [8, 9]}}
{"token": ["A", "21-year-old", "woman", "with", "eventually", "fatal", "malignant", "atrophic", "papulosis", "C0221011#ent", "<e1>", "was", "treated", "primarily", "with", "the", "C0016018#ent", "<e2>", "phenformin", "hydrochloride", "ethylestrenol", "."], "h": {"id": "C0221011", "name": "C0221011#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [16, 17]}}
{"token": ["We", "studied", "granulomatous", "uveitis", "reactions", "to", "C0041030#ent", "<e1>", "%", "therapy", "for", "C0017612#ent", "<e2>", "two", "patients", "in", "the", "United", "States"], "h": {"id": "C0041030", "name": "C0041030#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [11, 12]}}
{"token": ["Overall", ",", "30", "%", "(", "41", "of", "139", ")", "of", "C1367452#ent", "<e1>", "were", "MSI+", ",", "with", "C0002085#ent", "<e2>", "shifts", "at", "one", "to", "eight", "markers", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [16, 17]}}
{"token": ["Because", "the", "regions", "of", "interest", "are", "also", "shared", "by", "C0002085#ent", "<e1>", "of", "other", "groups", ",", "allele-specific", "or", "C1367452#ent", "<e2>", "needed", "to", "amplify", "only", "the", "C0002085#ent", "<e1>", "under", "study", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}}
{"token": ["A", "new", "antiarrhythmic", "drug", "C0606404#ent", "<e1>", ",", "5-phenacyl-thieno[3,2-c]yridinium", ",", "was", "compared", "with", "procainamide", "and", "C0023660#ent", "<e2>", "in", "a", "two-stage", "coronary", "ligation", "arrhythmia", "model", "for", "its", "efficacy", "and", "electrophysiological", "properties"], "h": {"id": "C0606404", "name": "C0606404#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [14, 15]}}
{"token": ["C0606404#ent", "<e1>", "and", "procainamide", "increased", "the", "frequency", "of", "ventricular", "pacemaker", "activity", "while", "C0023660#ent", "<e2>", "decreased", "it", "."], "h": {"id": "C0606404", "name": "C0606404#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [12, 13]}}
{"token": ["The", "tyrosine", "kinase", "inhibitor", "C0062566#ent", "<e1>", "A", "blocked", "the", "induction", "of", "IL-6", "by", "C1335093#ent", "<e2>", "HEC", "."], "h": {"id": "C0062566", "name": "C0062566#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335093", "name": "C1335093#ent", "pos": [13, 14]}}
{"token": ["Mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e1>", "(", "or", "C0600388#ent", "<e2>", "Erks", ")", "and", "stress-activated", "protein", "SAP", ")", "C0031727#ent", "<e1>", "mediate", "cellular", "responses", "a", "wide", "variety", "of", "signals", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}}
{"token": ["Basal", "phosphorylation", "of", "C0600388#ent", "<e1>", "Erks", ")", "1", "and", "2", ",", "C0031727#ent", "<e2>", "activated", "by", "heregulin", "treatment", ",", "was", "also", "observed", "in", "ebp1", "transfectants", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["Extracellular", "C0600388#ent", "<e1>", "2", "(", "ERK1/2", ")", "are", "a", "group", "of", "C0031727#ent", "<e2>", "that", "play", "an", "important", "role", "in", "proliferation", "and", "differentiation", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["The", "C0600388#ent", "<e1>", "PD", "98059", "reduced", "activation", "of", "all", "three", "C0031727#ent", "<e2>", "but", "failed", "to", "alter", "apoptosis", "in", "DENSPM-treated", "SK-MEL-28", "cells", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}}
{"token": ["The", "C1280469#ent", "<e1>", "fibre", "projection", "from", "the", "C3829257#ent", "<e2>", "was", "found", "to", "arise", "almost", "entirely", "from", "the", "ipsilateral", "nucleus", ",", "primarily", "from", "its", "magnocellular", "region", "."], "h": {"id": "C1280469", "name": "C1280469#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3829257", "name": "C3829257#ent", "pos": [7, 8]}}
{"token": ["Blockade", "of", "postganglionic", "parasympathetic", "neurotransmission", "with", "C0104658#ent", "<e1>", "1", "mg/kg", ")", "or", "blockade", "of", "sympathetic", "neurotransmission", "the", "alpha-adrenoceptor", "antagonist", "C0031448#ent", "<e2>", "(", "1", "mg/kg", ")", "did", "not", "attenuate", "the", "suppressive", "effect", "of", "morphine", "."], "h": {"id": "C0104658", "name": "C0104658#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [19, 20]}}
{"token": ["TNF-alpha", "stimulated", "these", "changes", "in", "part", "by", "increasing", "transcription", "and", "stabilization", "of", "RNA", "for", "C1332109#ent", "<e1>", ",", "an", "EGF", "receptor", "ligand", ",", "and", "C1332109#ent", "<e1>", "directly", "increased", "HPV-16", "E6/E7", "and", "C1332694#ent", "<e1>", "RNAs", "."], "h": {"id": "C1332109", "name": "C1332109#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332694", "name": "C1332694#ent", "pos": [30, 31]}}
{"token": ["Cannabidiol", "(", "C0006863#ent", "<e1>", ")", "was", "metabolized", "in", "vitro", "rat", "liver", "C3541394#ent", "<e2>", "."], "h": {"id": "C0006863", "name": "C0006863#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["These", "include", "C0149871#ent", "<e1>", "peroneal", "palsy", "infection", ",", "anemia", ",", "and", "C1527395#ent", "<e2>"], "h": {"id": "C0149871", "name": "C0149871#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1527395", "name": "C1527395#ent", "pos": [11, 12]}}
{"token": ["We", "have", "evaluated", "the", "effect", "of", "subacute", "dosing", "with", "C0078595#ent", "<e1>", ",", "a", "beta-1", "adrenoreceptor", "partial", "with", "inotropic", "properties", "on", "right", "ventricular", "function", "patients", "with", "C1705998#ent", "<e2>", "."], "h": {"id": "C0078595", "name": "C0078595#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705998", "name": "C1705998#ent", "pos": [25, 26]}}
{"token": ["Immunoprecipitates", "from", "a", "further", "93", "sera", "from", "patients", "with", "ANA-positive", "autoimmune", "diseases", "than", "C1290138#ent", "<e1>", "not", "precipitate", "C0035681#ent", "<e2>"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [17, 18]}}
{"token": ["These", "include", "lamin", "A/C", "autosomal", "dominant", "Emery-Dreifuss", "muscular", "dystrophy", "SMN", "in", "C0043116#ent", "<e1>", "SIX5", "in", "myotonic", "dystrophy", "calpain3", "in", "C0686353#ent", "<e2>", "PABP2", "in", "oculopharyngeal", "dystrophy", "androgen", "receptor", "spinal", "and", "bulbar", "muscular", "atrophy", "the", "ataxins", "in", "hereditary", "ataxias"], "h": {"id": "C0043116", "name": "C0043116#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [19, 20]}}
{"token": ["The", "following", "diagnoses", "were", "made", "for", "the", "remaining", "cases", "without", "deletions", "with", "the", "aid", "of", "a", "muscle", "biopsy", "C0043116#ent", "<e1>", "congenital", "myopathy", "sarcoglycan", "deficiency", "and", "unclassified", "C0686353#ent", "<e2>"], "h": {"id": "C0043116", "name": "C0043116#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [26, 27]}}
{"token": ["The", "increase", "in", "retinal", "blood", "flow", "C0000981#ent", "<e1>", "may", "serve", "to", "limit", "optic", "disc", "retinal", "ischaemia", "C0017601#ent", "<e2>", "central", "retinal", "artery", "occlusion", "."], "h": {"id": "C0000981", "name": "C0000981#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [16, 17]}}
{"token": ["Orally", "administered", "C0000981#ent", "<e1>", "has", "a", "limited", "use", "in", "C0017601#ent", "<e2>", "due", "to", "the", "systemic", "side", "effects", "associated", "with", "use", "."], "h": {"id": "C0000981", "name": "C0000981#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [9, 10]}}
{"token": ["Similarly", ",", "specific", "ratios", "of", "enzymes", "catalyzing", "unidirectional", "reactions", "in", "hexose", "metabolism", "hexokinase", ",", "C0162449#ent", "<e1>", ",", "fructose-1,6-bisphosphatase", ")", "separate", "the", "two", "C0225326#ent", "<e2>", "populations", "."], "h": {"id": "C0162449", "name": "C0162449#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [22, 23]}}
{"token": ["This", "increase", "in", "C1413043#ent", "<e1>", "+", "results", "in", "the", "destruction", "of", "cyclin", "B1", "the", "regulatory", "subunit", "C0080054#ent", "<e2>", "that", "leads", "to", "inactivation", "of", "maturation", "promoting", "factor", "(", "MPF", ")", "and", "egg", "activation"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [16, 17]}}
{"token": ["The", "C1416797#ent", "<e1>", "independent", "of", "C0014442#ent", "<e2>", "concentration", ",", "indicating", "that", "slow", "pH-induced", "conformational", "changes", "in", "the", "protein", "must", "occur", "during", "assay", "."], "h": {"id": "C1416797", "name": "C1416797#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}}
{"token": ["The", "C1416797#ent", "<e1>", "related", "to", "the", "time", "required", "for", "free", "C0014442#ent", "<e2>", "and", "free", "promoter", "combine", "and", "isomerize", "into", "a", "functionally", "active", "."], "h": {"id": "C1416797", "name": "C1416797#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "human", "C1418752#ent", "<e1>", "and", "POMT2", "cause", "a", "group", "of", "C0751336#ent", "<e2>", "to", "reduced", "O-glycosylation", "of", "alpha-dystroglycan", "."], "h": {"id": "C1418752", "name": "C1418752#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751336", "name": "C0751336#ent", "pos": [11, 12]}}
{"token": ["Nonetheless", ",", "our", "analysis", "indicates", "that", "gross", "structural", "alterations", "of", "the", "MDM2", "and", "C1705522#ent", "<e1>", "genes", "are", "infrequent", "events", "in", "the", "C2984892#ent", "<e2>", "of", "NPC", "."], "h": {"id": "C1705522", "name": "C1705522#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2984892", "name": "C2984892#ent", "pos": [21, 22]}}
{"token": ["In", "England", "and", "Wales", "there", "is", "a", "strong", "geographical", "relation", "between", "current", "mortality", "from", "C0008677#ent", "<e1>", "emphysema", "in", "adults", "and", "infant", "mortality", "from", "C0149514#ent", "<e2>", "and", "pneumonia", "50", "years", "ago", "."], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [23, 24]}}
{"token": ["Increased", "diurnal", "variation", "expiratory", "flow", "has", "been", "documented", "in", "patients", "with", "C0008677#ent", "<e1>", "but", "this", "could", "be", "secondary", "to", "disease", "process", "C0149514#ent", "<e2>", "rather", "than", "an", "associated", "disease", "namely", ",", "asthma", "."], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [21, 22]}}
{"token": ["The", "serum", "IFN-gamma", "levels", "of", "15", "patients", "with", "C0008677#ent", "<e1>", "15", "patients", "with", "cor", "pulmonale", "15", "patients", "with", "C0149514#ent", "<e2>", "and", "15", "normal", "subjects", "measured", "by", "radio-immuno-assay", "."], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [18, 19]}}
{"token": ["The", "immunohistochemical", "distribution", "of", "C0010803#ent", "<e1>", "is", "reported", "in", "experimental", "carcinogenesis", "the", "mouse", "submandibular", "gland", "C1826968#ent", "<e2>", ")", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826968", "name": "C1826968#ent", "pos": [15, 16]}}
{"token": ["We", "determined", "the", "cell", "type", "expression", "of", "C0010803#ent", "<e1>", "the", "mouse", "C1826968#ent", "<e2>", "in", "vivo", "we", "demonstrate", "that", "SIMS", "and", "SIMP", "cell", "lines", "duct-specific", "cytokeratins"], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826968", "name": "C1826968#ent", "pos": [11, 12]}}
{"token": ["However", ",", "C3540631#ent", "<e1>", "could", "be", "targeted", "to", "exosomes", "in", "the", "absence", "of", "C1413240#ent", "<e2>", "and", "of", "another", "tetraspanin", ",", "CD9", "."], "h": {"id": "C3540631", "name": "C3540631#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [13, 14]}}
{"token": ["[3H]PK", "14105", "photolabeled", "the", "bovine", "C1823521#ent", "<e1>", "and", "the", "C0311284#ent", "<e2>", "was", "estimated", "under", "nondenaturing", "(", "200", "kDa", ")", "and", "denaturing", "(", "17", "kDa", ")", "conditions", "."], "h": {"id": "C1823521", "name": "C1823521#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0311284", "name": "C0311284#ent", "pos": [9, 10]}}
{"token": ["Mice", "on", "C1705240#ent", "<e1>", "ate", "the", "same", "calories", "as", "mice", "on", "C", "and", "C1313497#ent", "<e2>", ",", "but", "weight", "dropped", "and", "stabilized", "at", "85", "%", "initial", "weight", ",", "similar", "to", "CR", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1313497", "name": "C1313497#ent", "pos": [13, 14]}}
{"token": ["C0206256#ent", "<e1>", "IEGs", ":", "c-fos", "and", "Fos-related", "antigen", "C1538772#ent", "<e2>", "]", ")", "are", "useful", "indicators", "of", "changes", "in", "neuronal", "activity", "plasticity", "."], "h": {"id": "C0206256", "name": "C0206256#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538772", "name": "C1538772#ent", "pos": [8, 9]}}
{"token": ["In", "the", "first", "case", "the", "diagnosis", "of", "\"", "widespread", "nonspecific", "C0009319#ent", "<e1>", "was", "made", "compatible", "with", "\"", "C0085819#ent", "<e2>", "and", "Clostridium", "difficile", "isolated", "from", "the", "feces", "."], "h": {"id": "C0009319", "name": "C0009319#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0085819", "name": "C0085819#ent", "pos": [17, 18]}}
{"token": ["The", "KL-6", "values", "were", "markedly", "elevated", "in", "patients", "with", "pulmonary", "complications", "but", "not", "in", "those", "with", "acute", "and", "chronic", "graft-versus-host", "disease", "hemorrhagic", "cystitis", "C0276226#ent", "<e1>", "sepsis", ",", "and", "C0019156#ent", "<e2>"], "h": {"id": "C0276226", "name": "C0276226#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0019156", "name": "C0019156#ent", "pos": [28, 29]}}
{"token": ["Therefore", ",", "we", "hypothesized", "that", "single-nucleotide", "polymorphisms", "SNPs", ")", "of", "BAX", "and", "C0376515#ent", "<e1>", "promoters", "and", "the", "C3273300#ent", "<e2>", "SNP", "may", "jointly", "contribute", "to", "cancer", "risk"], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273300", "name": "C3273300#ent", "pos": [17, 18]}}
{"token": ["While", "a", "biphasic", "disease", "has", "been", "discussed", "for", "C0038522#ent", "<e1>", "with", "a", "prominent", "loss", "of", "viral", "protein", "expression", ",", "C0032372#ent", "<e2>", "has", "been", "associated", "with", "virus", "persistence", "."], "h": {"id": "C0038522", "name": "C0038522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032372", "name": "C0032372#ent", "pos": [19, 20]}}
{"token": ["Wild-type", "C0134982#ent", "<e1>", "and", "chimeric", "Syk", "molecules", "with", "the", "C0080298#ent", "<e2>", "myristylation", "sequence", "at", "the", "amino-terminus", "were", "expressed", "in", "a", "Syk-negative", "mast", "cell", "line", "."], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [9, 10]}}
{"token": ["After", "a", "single", "administration", "of", "C0935868#ent", "<e1>", ",", "a", "30", "%", "reduction", "in", "C0812246#ent", "<e2>", "produced", "by", "liver", "slices", "was", "observed", "."], "h": {"id": "C0935868", "name": "C0935868#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [13, 14]}}
{"token": ["The", "cellular", "origin", "a", "soluble", "phospholipid-binding", "protein", "C2698695#ent", "<e1>", ")", "in", "rat", "testicular", "and", "epididymal", "secretions", "been", "investigated", "C1516876#ent", "<e2>", "and", "immunologically", "."], "h": {"id": "C2698695", "name": "C2698695#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [18, 19]}}
{"token": ["N-APase", "was", "absent", "from", "the", "sera", "of", "healthy", "individuals", "and", "of", "patients", "with", "acute", "and", "chronic", "granulocytic", "leukaemia", "breast", "cancer", "colon", "cancer", "rheumatoid", "arthritis", "C0009324#ent", "<e1>", "systemic", "lupus", "erythematosis", "hepatitis", "and", "C0022354#ent", "<e2>"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [31, 32]}}
{"token": ["It", "is", "important", "to", "look", "for", "the", "disease", "in", "immunodeficient", "children", "and", "in", "patients", "with", "C0009324#ent", "<e1>", "and", "to", "consider", "PSC", "in", "the", "differential", "diagnosis", "C0022354#ent", "<e2>"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [25, 26]}}
{"token": ["C0036572#ent", "<e1>", "in", "10", "patients", ",", "lymphoproliferative", "disorders", "4", ",", "and", "C0006272#ent", "<e2>", "17", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006272", "name": "C0006272#ent", "pos": [11, 12]}}
{"token": ["C0085437#ent", "<e1>", "have", "affected", "the", "clinical", "course", "severe", "C0014550#ent", "<e2>", "infancy", "in", "twin", "1", "resulting", "in", "delayed", "onset", "of", "myoclonus", "and", "more", "favorable", "language", "development", "in", "twin", "1", "in", "twin", "2", "who", "did", "not", "experience", "bacterial", "meningitis"], "h": {"id": "C0085437", "name": "C0085437#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014550", "name": "C0014550#ent", "pos": [8, 9]}}
{"token": ["Immunization", "with", "C1418917#ent", "<e1>", "in", "incomplete", "C0281643#ent", "<e2>", "IFA", ")", "did", "not", "change", "the", "difference", "between", "lines", ",", "whereas", "immunization", "with", "complete", "C0281643#ent", "<e2>", "CFA", ")", "diminished", "the", "difference", "between", "lines", "."], "h": {"id": "C1418917", "name": "C1418917#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0281643", "name": "C0281643#ent", "pos": [6, 7]}}
{"token": ["As", "a", "control", ",", "mice", "(", "C3H/HeN", ")", "were", "immunized", "with", "intraperitoneal", "injection", "of", "C1418917#ent", "<e1>", "and", "complete", "C0281643#ent", "<e2>", "and", "additional", "C1418917#ent", "<e1>", "after", "30", "days", "."], "h": {"id": "C1418917", "name": "C1418917#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0281643", "name": "C0281643#ent", "pos": [18, 19]}}
{"token": ["The", "mapping", "of", "the", "C0002565#ent", "<e1>", "the", "X", "chromosome", "that", "a", "defect", "in", "this", "C0079429#ent", "<e2>", "may", "be", "the", "primary", "cause", "of", "X-linked", "sideroblastic", "anemia"], "h": {"id": "C0002565", "name": "C0002565#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", "C1708802#ent", "<e1>", "physically", "interacts", "with", "NIK", "and", "with", "IKK2", ",", "and", "both", "XIAP", "or", "active", "C1708802#ent", "<e1>", "can", "stimulate", "C3272751#ent", "<e1>", "."], "h": {"id": "C1708802", "name": "C1708802#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3272751", "name": "C3272751#ent", "pos": [22, 23]}}
{"token": ["This", "retrospective", "case", "review", "conducted", "on", "35", "Thai", "hospitalized", "C0019163#ent", "<e1>", "carriers", "who", "had", "diagnosis", "of", "C0023885#ent", "<e2>"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023885", "name": "C0023885#ent", "pos": [16, 17]}}
{"token": ["We", "have", "studied", "RET-Y", "and", "RBC-Y", "indices", "in", "two", "groups", "of", "patients", "with", "microcytosis", "to", "verify", "if", "these", "parameters", "could", "be", "used", "to", "differentiate", "C0162316#ent", "<e1>", "anemia", "from", "C0005283#ent", "<e2>"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [28, 29]}}
{"token": ["These", "results", "point", "out", "that", "anisocytosis", "is", "higher", "in", "C0162316#ent", "<e1>", "than", "in", "C0005283#ent", "<e2>", "."], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [13, 14]}}
{"token": ["Central", "and", "renal", "haemodynamics", "monitored", "after", "acute", "oral", "administration", "0.075", "mg/kg", ")", "of", "C0015772#ent", "<e1>", "in", "combination", "with", "the", "beta-blocker", "and", "C0596110#ent", "<e2>", "."], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [21, 22]}}
{"token": ["As", "a", "vasodilator", "antihypertensive", "agent", "C0015772#ent", "<e1>", "possesses", "potentially", "advantageous", "C0596110#ent", "<e2>", "and", "natriuretic", "properties"], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [10, 11]}}
{"token": ["3", "In", "a", "separate", "open", "study", "58", "hypertensive", "patients", "were", "treated", "with", "C0015772#ent", "<e1>", "in", "addition", "to", "a", "C0596110#ent", "<e2>", "and", "a", "beta-adrenoceptor", "blocker", "up", "to", "1", "year", "."], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [18, 19]}}
{"token": ["At", "relatively", "low", "doses", "C0015772#ent", "<e1>", "appears", "to", "be", "an", "effective", "antihypertensive", "agent", "initially", "exerting", "some", "C0596110#ent", "<e2>", "and", "natriuretic", "action", "subsequently", "being", "devoid", "of", "a", "water-", "and", "sodium-retaining", "action", "."], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "we", "tested", "the", "ability", "of", "C1335607#ent", "<e1>", "deficient", "fibroblasts", ",", "derived", "from", "a", "C1433276#ent", "<e2>", "patient", "to", "recover", "from", "hydrogen", "peroxide", "H(2)O(2))-induced", "oxidative", "stress/damage", "."], "h": {"id": "C1335607", "name": "C1335607#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1433276", "name": "C1433276#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "confirm", "that", "BGS", "in", "a", "subgroup", "of", "patients", "is", "due", "to", "C1335607#ent", "<e1>", "mutations", "and", "could", "be", "integrated", "into", "a", "clinical", "spectrum", "encompasses", "C1433276#ent", "<e2>", "and", "RAPADILINO", "syndrome", "."], "h": {"id": "C1335607", "name": "C1335607#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1433276", "name": "C1433276#ent", "pos": [25, 26]}}
{"token": ["The", "study", "group", "consisted", "of", "15", "patients", "with", "C0264766#ent", "<e1>", "5", "patients", "with", "left", "atrial", "myxoma", "and", "7", "patients", "without", "underlying", "C0018799#ent", "<e2>", "they", "were", "compared", "with", "20", "normal", "controls", "sinus", "rhythm", "."], "h": {"id": "C0264766", "name": "C0264766#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [21, 22]}}
{"token": ["C0264766#ent", "<e1>", "the", "most", "common", "C0018799#ent", "<e2>", "the", "1950s", "."], "h": {"id": "C0264766", "name": "C0264766#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [5, 6]}}
{"token": ["The", "C0017356#ent", "<e1>", "which", "encodes", "related", "C1333199#ent", "<e2>", "both", "human", "(", "HIV", ")", "and", "simian", "(", "SIV", ")", "immunodeficiency", "viruses", "dispensable", "for", "viral", "replication", "in", "vitro"], "h": {"id": "C0017356", "name": "C0017356#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333199", "name": "C1333199#ent", "pos": [6, 7]}}
{"token": ["C1335047#ent", "<e1>", "negative", "for", "ER", "and", "C1705324#ent", "<e2>", "in", "all", "but", "one", "case", "in", "which", "weak", "staining", "for", "C1705324#ent", "<e2>", "was", "present", "adjacent", "to", "a", "follicular", "adenoma"], "h": {"id": "C1335047", "name": "C1335047#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705324", "name": "C1705324#ent", "pos": [6, 7]}}
{"token": ["Pretreatment", "with", "C0008221#ent", "<e1>", "(", "20", "mg/kg", "IV", "26", "min", "before", "C0022614#ent", "<e2>", ")", "also", "markedly", "diminished", "the", "derangement", "of", "f-SEP", "."], "h": {"id": "C0008221", "name": "C0008221#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [11, 12]}}
{"token": ["C0008221#ent", "<e1>", "produced", "weak", "nonselective", "inhibition", "of", "human", "C0022614#ent", "<e2>", "NR1a+NR2A", "and", "NR1a+NR2B", "receptors", "."], "h": {"id": "C0008221", "name": "C0008221#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [8, 9]}}
{"token": ["C0297817#ent", "<e1>", "be", "eluted", "from", "the", "C0350056#ent", "<e2>", "with", "dGTP", "or", "urea", "."], "h": {"id": "C0297817", "name": "C0297817#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0350056", "name": "C0350056#ent", "pos": [6, 7]}}
{"token": ["The", "Shwachman-Bodian-Diamond", "syndrome", "C3273615#ent", "<e1>", ")", "gene", "is", "a", "causative", "gene", "C1426244#ent", "<e2>", "an", "autosomal", "recessive", "disorder", "exocrine", "pancreatic", "insufficiency", "bone", "marrow", "dysfunction", "skeletal", "dysplasia"], "h": {"id": "C3273615", "name": "C3273615#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1426244", "name": "C1426244#ent", "pos": [11, 12]}}
{"token": ["We", "quantitated", "the", "dephosphorylation", "of", "various", "sites", "of", "Alzheimer", "disease", "hyperphosphorylated", "tau", "by", "C1418845#ent", "<e1>", "purified", "from", "six", "(", "three", "C0078939#ent", "<e2>", "and", "three", "control", ")", "autopsied", "human", "brains", "."], "h": {"id": "C1418845", "name": "C1418845#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [20, 21]}}
{"token": ["Morphologic", "analysis", "glomeruli", "from", "C0042749#ent", "<e1>", "(", "infected", ")", "normal", "chimpanzee", "serum-treated", "animals", "revealed", "significant", "C0022658#ent", "<e2>", "2", "weeks", "following", "virus", "inoculation", "with", "glomerular", "immune", "complex", "deposits", "and", "C-type", "viral", "particles", "by", "electron", "microscopy"], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [15, 16]}}
{"token": ["Removal", "of", "the", "binding", "site", "MAP2", "and", "C2697954#ent", "<e1>", "from", "tubulin", "by", "C0752243#ent", "<e2>", "not", "influence", "the", "association", "of", "tubulin", "with", "G", "protein", "as", "demonstrated", "in", "overlay", "studies", "[125I]tubulin", "."], "h": {"id": "C2697954", "name": "C2697954#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752243", "name": "C0752243#ent", "pos": [12, 13]}}
{"token": ["Other", "causes", "include", "the", "administration", "of", "C0003015#ent", "<e1>", "indomethacin", "and", "C0040373#ent", "<e2>", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040373", "name": "C0040373#ent", "pos": [10, 11]}}
{"token": ["Whereas", "low", "doses", "induced", "p21/Cip1/Waf1", "and", "HDM2", ",", "high", "doses", "only", "C1333655#ent", "<e1>", "and", "BAX", "increasing", "the", "BAX", ":", "C0376515#ent", "<e2>"], "h": {"id": "C1333655", "name": "C1333655#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "demonstrate", "that", "cytotoxic", "DNA", "damage", "an", "increase", "in", "the", "expression", "of", "MCL1", "along", "with", "increases", "in", "C1333655#ent", "<e1>", "and", "BAX", "and", "a", "decrease", "in", "C0376515#ent", "<e2>", "."], "h": {"id": "C1333655", "name": "C1333655#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [26, 27]}}
{"token": ["PNP", "deficiency", "an", "autosomal", "recessive", "C0025517#ent", "<e1>", "by", "severe", "combined", "immunodeficiency", ",", "C0002880#ent", "<e2>", "and", "by", "a", "complex", "of", "neurologic", "manifestations", "ataxia", ",", "developmental", "delay", "and", "spasticity", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002880", "name": "C0002880#ent", "pos": [12, 13]}}
{"token": ["C0035242#ent", "<e1>", "present", "as", "neonatal", "acute", "liver", "failure", "C0015695#ent", "<e2>", "cholestasis", ",", "or", "cirrhosis", "with", "chronic", "liver", "failure", "insidious", "onset"], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015695", "name": "C0015695#ent", "pos": [8, 9]}}
{"token": ["Norepinephrine", "has", "been", "identified", "as", "the", "principal", "C3536742#ent", "<e1>", "in", "individual", "neurons", "of", "the", "C1258666#ent", "<e2>", "of", "an", "arthropod", ",", "the", "cattle", "tick", "Boophilus", "microplus"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [14, 15]}}
{"token": ["The", "male", "sex", "steroid", "testosterone", "evidently", "influences", "the", "C3536742#ent", "<e1>", "turnover", "and", "cellular", "growth", "development", "in", "the", "male", "C1258666#ent", "<e2>"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "the", "genetic", "relationships", "yeasts", "from", "the", "most", "common", "forms", "of", "C0006840#ent", "<e1>", "thrush", "and", "C0038364#ent", "<e2>"], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038364", "name": "C0038364#ent", "pos": [16, 17]}}
{"token": ["These", "results", "further", "indicate", "that", "increased", "secretion", "of", "the", "acid", "proteinase", "to", "be", "of", "pathogenetic", "significance", "the", "C0006840#ent", "<e1>", "of", "HIV-seropositive", "patients", "but", "not", "in", "C0038364#ent", "<e2>"], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0038364", "name": "C0038364#ent", "pos": [25, 26]}}
{"token": ["Oral", "yeasts", "an", "important", "component", "of", "the", "resident", "microbial", "ecology", "of", "the", "oral", "cavity", "but", "they", "are", "also", "associated", "with", "forms", "of", "C0006840#ent", "<e1>", "such", "as", "C0038364#ent", "<e2>"], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038364", "name": "C0038364#ent", "pos": [26, 27]}}
{"token": ["We", "investigated", "the", "effects", "of", "different", "antioxidants", "such", "as", "L-ascorbic", "acid", "C0007367#ent", "<e1>", ",", "and", "superoxide", "dismutase", "SOD", ")", ",", "on", "the", "C1120843#ent", "<e2>", "activation", "induced", "by", "oxidative", "stress", "the", "isolated", "perfused", "amphibian", "heart", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [22, 23]}}
{"token": ["C0007367#ent", "<e1>", "inhibited", "phosphorylation", "of", "ERKs", "and", "C1120843#ent", "<e2>", "as", "well", "as", "AP-1", "activation", "induced", "by", "FFSi", ",", "suggesting", "the", "involvement", "of", "H(2)O(2", ")", "in", "the", "mechanism", "of", "silica-induced", "AP-1", "activation", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [7, 8]}}
{"token": ["These", "data", "reveal", "an", "easily", "discernible", "sexually", "dimorphic", "pattern", "of", "expression", "and", "confirm", "that", "C1412384#ent", "<e1>", "can", "be", "used", "as", "a", "C1423060#ent", "<e2>", "infancy", "and", "early", "childhood"], "h": {"id": "C1412384", "name": "C1412384#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1423060", "name": "C1423060#ent", "pos": [21, 22]}}
{"token": ["The", "effects", "of", "C0282555#ent", "<e1>", "passive", "air-pouch", "anaphylaxis", "(", "C2984582#ent", "<e2>", ")", "in", "the", "dorsal", "skin", "rats", "were", "investigated", "by", "measuring", "plasma", "exudation", "and", "histamine", "content", "in", "the", "pouch", "fluid"], "h": {"id": "C0282555", "name": "C0282555#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2984582", "name": "C2984582#ent", "pos": [9, 10]}}
{"token": ["DMalpha2", ",", "the", "closest", "C1334043#ent", "<e1>", "to", "mammalian", "PLP/DM20", ",", "is", "coexpressed", "with", "C1417248#ent", "<e2>", "in", "oligodendrocytes", "and", "upregulated", "after", "optic", "nerve", "lesion"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417248", "name": "C1417248#ent", "pos": [13, 14]}}
{"token": ["Two", "cytoplasmic", "proteins", "C0289313#ent", "<e1>", "and", "chloramphenicol", "C0001390#ent", "<e2>", "and", "a", "VirE2green", "fluorescent", "protein", "construct", "were", "not", "detected", "in", "the", "above", "fraction", "."], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001390", "name": "C0001390#ent", "pos": [7, 8]}}
{"token": ["In", "this", "prospective", "study", "the", "prevalence", "and", "characteristics", "of", "troponin", "elevation", "were", "examined", "in", "244", "patients", "with", "C0948008#ent", "<e1>", "without", "overt", "C0151744#ent", "<e2>"], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [21, 22]}}
{"token": ["C0149368#ent", "<e1>", "more", "effective", "and", "C0772239#ent", "<e2>", "effective", "than", "ZnCl2", "."], "h": {"id": "C0149368", "name": "C0149368#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0772239", "name": "C0772239#ent", "pos": [5, 6]}}
{"token": ["It", "joins", "the", "5", "'", "section", "of", "the", "C1335654#ent", "<e1>", "the", "almost", "complete", "C0079941#ent", "<e2>", "MTG8", "(", "ETO", ")", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [13, 14]}}
{"token": ["Resveratrol", "restored", "CSE-depleted", "GSH", "levels", "by", "upregulation", "of", "C1423891#ent", "<e1>", "via", "activation", "of", "C1417701#ent", "<e2>", "and", "also", "quenched", "CSE-induced", "release", "of", "reactive", "oxygen", "species"], "h": {"id": "C1423891", "name": "C1423891#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417701", "name": "C1417701#ent", "pos": [13, 14]}}
{"token": ["We", "also", "found", "that", "the", "induction", "of", "C1423891#ent", "<e1>", "expression", "was", "abrogated", "by", "siRNA", "for", "C1417701#ent", "<e2>", "."], "h": {"id": "C1423891", "name": "C1423891#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417701", "name": "C1417701#ent", "pos": [15, 16]}}
{"token": ["We", "tested", "the", "effects", "on", "the", "protective", "effect", "C1416867#ent", "<e1>", "resulting", "from", "antagonism", "of", "protein", "kinase", "C", "potassium", "ATP", "channels", "C0907533#ent", "<e2>", "or", "hydroxyl", "radicals"], "h": {"id": "C1416867", "name": "C1416867#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "Hodgkin", "and", "Reed-Sternberg", "cells", "primary", "tumor", "C1416867#ent", "<e1>", "tissues", "also", "C0907533#ent", "<e2>", "and", "abundantly", "express", "XIAP", "."], "h": {"id": "C1416867", "name": "C1416867#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [12, 13]}}
{"token": ["C3810569#ent", "<e1>", "fractions", "containing", "electrophoretically", "pure", "34", "C1705240#ent", "<e2>", "DBP", "showed", "an", "endonuclease", "activity", "of", "converting", "plasmid", "pBR", "322", "DNA", "to", "the", "linear", "form"], "h": {"id": "C3810569", "name": "C3810569#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [7, 8]}}
{"token": ["We", "show", "that", "a", "series", "of", "14", "MCC-deficient", "probands", "defines", "two", "complementation", "groups", ",", "C1424683#ent", "<e1>", "and", "2", ",", "resulting", "from", "mutations", "in", "MCCB", "and", "C1417066#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1424683", "name": "C1424683#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417066", "name": "C1417066#ent", "pos": [25, 26]}}
{"token": ["These", "results", "indicate", "the", "importance", "of", "C1706351#ent", "<e1>", "in", "Fc", "gamma", "phagocytosis", "and", "demonstrate", "that", "C1527940#ent", "<e2>", "and", "syk", "differ", "in", "their", "requirement", "for", "a", "Src-related", "kinase", "in", "signal", "transduction"], "h": {"id": "C1706351", "name": "C1706351#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1527940", "name": "C1527940#ent", "pos": [15, 16]}}
{"token": ["The", "interdomain", "A", "lying", "between", "the", "two", "SH2", "domains", "highly", "conserved", "among", "different", "species", "of", "C1706351#ent", "<e1>", "and", "between", "C1706351#ent", "<e1>", "and", "C1527940#ent", "<e1>", "."], "h": {"id": "C1706351", "name": "C1706351#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1527940", "name": "C1527940#ent", "pos": [22, 23]}}
{"token": ["To", "examine", "the", "mRNA", "expression", "of", "the", "linker", "for", "activation", "of", "T", "cell", "LAT", ")", "and", "its", "upstream", "regulatory", "factors", "C1706351#ent", "<e1>", ",", "Lck", "and", "C1527940#ent", "<e2>", ")", "in", "the", "peripheral", "blood", "T", "cells", "asthmatic", "patients", "."], "h": {"id": "C1706351", "name": "C1706351#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1527940", "name": "C1527940#ent", "pos": [25, 26]}}
{"token": ["Transection", "of", "specific", "ganglionic", "nerve", "roots", "depleted", "TyrOHase", "catalytic", "activity", "and", "neuronal", "immunoreactivity", "within", "the", "petrosal", "ganglion", "suggesting", "that", "target", "organ", "innervation", "regulates", "C0027203#ent", "<e1>", "levels", "within", "C1258666#ent", "<e2>", "perikarya", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [27, 28]}}
{"token": ["Immunolocalization", "studies", "then", "confirmed", "a", "strong", "expression", "of", "the", "C0027203#ent", "<e1>", "within", "the", "C1258666#ent", "<e2>", "axons", ",", "the", "carotid", "adventitia", "receives", "these", "axons", ",", "and", "the", "predominantly", "sympathetic", "axon", "terminals", "the", "iris-choroid", "microvasculature", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [13, 14]}}
{"token": ["Axotomy", "before", "the", "twelfth", "postnatal", "day", "results", "in", "a", "marked", "atrophy", "of", "the", "C1258666#ent", "<e1>", "and", "a", "reduction", "in", "the", "total", "C0027203#ent", "<e2>", "content", "of", "the", "C1258666#ent", "<e1>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [13, 14]}}
{"token": ["One", "patient", "developed", "C0235025#ent", "<e1>", "disappeared", "following", "discontinuation", "of", "C0026218#ent", "<e2>", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026218", "name": "C0026218#ent", "pos": [9, 10]}}
{"token": ["This", "shows", "that", "mtDNA", "mutations", "at", "8993", "can", "produce", "the", "clinical", "phenotype", "C0023264#ent", "<e1>", "addition", "to", "the", "phenotype", "of", "C0004134#ent", "<e2>", "and", "retinitis", "pigmentosa", "by", "Holt", "et", "al.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [19, 20]}}
{"token": ["Unlike", "many", "pathogenic", "mitochondrial", "DNA", "mutations", "the", "T8993", "G", "mutation", "associated", "with", "C0023264#ent", "<e1>", "LS", ")", "and", "neurogenic", "muscle", "weakness", "C0004134#ent", "<e2>", ",", "retinitis", "pigmentosa", "NARP", ")", "typically", "shows", "little", "variation", "in", "mutant", "load", "between", "different", "tissue", "types"], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [20, 21]}}
{"token": ["An", "18-year-old", "male", "patient", "presented", "with", "clinical", "and", "radiological", "evidence", "of", "C0023264#ent", "<e1>", "LS", ")", ",", "having", "developed", "progressive", "myoclonic", "epilepsy", "C0004134#ent", "<e2>", "previously", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [21, 22]}}
{"token": ["Under", "these", "conditions", ",", "Pgamma", "phosphorylated", "by", "C1565306#ent", "<e1>", "inhibited", "the", "light/GTPgammaS-activated", "C0031640#ent", "<e2>", "even", "in", "the", "presence", "of", "GTPgammaS/Talpha", "."], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [12, 13]}}
{"token": ["Mitogen-activated", "protein", "kinase", "C0752312#ent", "<e1>", ")", "or", "extracellular", "signal-regulated", "kinase", "ubiquitous", "C0031727#ent", "<e2>", "conserved", "from", "fungi", "to", "mammals", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["IL-4", "induced", "phosphorylation", "of", "p38", "mitogen-activated", "protein", "kinase", "stress-activated", "protein", "kinase/c-Jun", "kinase", "and", "C0752312#ent", "<e1>", "inhibitors", "of", "these", "C0031727#ent", "<e2>", "suppressed", "IL-4-induced", "proliferation", "of", "endometriotic", "stromal", "cells"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}}
{"token": ["The", "glycerol", "content", "also", "affected", "the", "rate", "of", "C0017237#ent", "<e1>", "of", "the", "C1442521#ent", "<e2>", "solution", "."], "h": {"id": "C0017237", "name": "C0017237#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [12, 13]}}
{"token": ["The", "identification", "of", "novel", "collagen", "VI", "chains", "carries", "implications", "for", "the", "etiology", "of", "C0011615#ent", "<e1>", "well", "as", "Bethlem", "myopathy", "C4225314#ent", "<e2>"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4225314", "name": "C4225314#ent", "pos": [19, 20]}}
{"token": ["C0026254#ent", "<e1>", "metabolized", "by", "C0919428#ent", "<e2>", "in", "a", "pH-dependent", "manner", "with", "increasing", "amounts", "of", "metabolism", "observed", "as", "the", "pH", "was", "decreased", "from", "7.8", "to", "5.8", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919428", "name": "C0919428#ent", "pos": [4, 5]}}
{"token": ["C0026254#ent", "<e1>", "MMC", ")", "is", "activated", "by", "DT-diaphorase", "(", "C0919428#ent", "<e2>", ")", "and", "cytochrome", "P450", "reductase", "P450R", ")", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919428", "name": "C0919428#ent", "pos": [9, 10]}}
{"token": ["Compounds", "such", "as", "C0026254#ent", "<e1>", "streptonigrin", "are", "efficiently", "bioactivated", "by", "C0919428#ent", "<e2>", "and", "have", "been", "used", "in", "an", "enzyme-directed", "approach", "to", "chemotherapy", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0919428", "name": "C0919428#ent", "pos": [10, 11]}}
{"token": ["Three", "out", "of", "54", "patients", "(", "5.5", "%", ")", "developed", "symptomatic", "C0029927#ent", "<e1>", "of", "which", "2", "required", "surgical", "intervention", "of", "C1457887#ent", "<e2>"], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [20, 21]}}
{"token": ["Recent", "progress", "in", "molecular", "genetic", "analyses", "C1418270#ent", "<e1>", "has", "led", "to", "the", "identification", "of", "a", "novel", "ubiquitin-like", "protein", "C1311470#ent", "<e2>", ",", "whose", "precise", "function", "still", "remains", "to", "be", "elucidated", "."], "h": {"id": "C1418270", "name": "C1418270#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1311470", "name": "C1311470#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "C1418270#ent", "<e1>", "encoding", "an", "C1311470#ent", "<e2>", "are", "a", "frequent", "cause", "of", "autosomal", "recessive", "parkinsonism", "are", "also", "involved", "in", "sporadic", "Parkinson's", "disease"], "h": {"id": "C1418270", "name": "C1418270#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1311470", "name": "C1311470#ent", "pos": [7, 8]}}
{"token": ["In", "global", "cerebral", "ischemia", "focal", "cerebral", "ischemia", "oxygen-glucose", "deprivation", "application", "of", "muscimol", "and", "C0004609#ent", "<e1>", ",", "agonists", "of", "C1414919#ent", "<e2>", "GABA(B", ")", "receptor", ",", "exerted", "neuroprotection", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414919", "name": "C1414919#ent", "pos": [18, 19]}}
{"token": ["Diazepam", "or", "gamma-hydroxybutyrate", ",", "but", "not", "C0004609#ent", "<e1>", ",", "prevented", "the", "changes", "in", "both", "C1414919#ent", "<e2>", "pharmacology", "and", "subunit", "mRNA", "levels", "induced", "by", "ethanol", "withdrawal", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414919", "name": "C1414919#ent", "pos": [14, 15]}}
{"token": ["Citalopram", "(", "C1427027#ent", "<e1>", ")", "is", "an", "C0003289#ent", "<e2>", "the", "group", "of", "selective", "serotonin", "reuptake", "inhibitors", "SSRIs", ")", "."], "h": {"id": "C1427027", "name": "C1427027#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [7, 8]}}
{"token": ["According", "to", "the", "proposed", "kinetic", "scheme", "the", "mutual", "sensitization", "the", "oxidation", "of", "this", "natural", "gas", "and", "NO", "proceeds", "through", "the", "NO", "to", "C1414404#ent", "<e1>", "conversion", "by", "C0018969#ent", "<e2>", ",", "CH3O2", ",", "and", "C2H5O2", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0018969", "name": "C0018969#ent", "pos": [26, 27]}}
{"token": ["This", "study", "investigates", "the", "effect", "of", "the", "oral", "combined", "C0009906#ent", "<e1>", "OCP", ")", "on", "beta2-adrenoceptor", "regulation", "and", "function", "in", "female", "C0004096#ent", "<e2>", "patients", "."], "h": {"id": "C0009906", "name": "C0009906#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [20, 21]}}
{"token": ["Eleven", "cases", "of", "liver", ",", "kidney", "or", "C0029927#ent", "<e1>", "treated", "by", "intracystic", "injection", "of", "absolute", "C0001962#ent", "<e2>", "which", "led", "to", "progressive", "reduction", "even", "disappearance", "of", "the", "cyst", "."], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [15, 16]}}
{"token": ["HPV-E6", "protein", "plays", "a", "critical", "role", "in", "the", "poly-ubiquitination", "of", "C2987364#ent", "<e1>", "p53", "by", "mediating", "the", "association", "of", "p53", "with", "E6-associated", "protein", "C2700100#ent", "<e2>", ")", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2700100", "name": "C2700100#ent", "pos": [22, 23]}}
{"token": ["Patient's", "age", ",", "sex", ",", "whether", "or", "not", "C0343065#ent", "<e1>", "predated", "or", "postdated", "onset", "of", "C0702166#ent", "<e2>", ",", "symptoms", "of", "lesions", ",", "premenstrual", "flare", "and", "history", "of", "atopy", "were", "recorded", "."], "h": {"id": "C0343065", "name": "C0343065#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0702166", "name": "C0702166#ent", "pos": [15, 16]}}
{"token": ["Both", "hOGG1", "and", "C0663246#ent", "<e1>", "were", "excluded", "as", "candidates", "for", "C1705143#ent", "<e2>", "."], "h": {"id": "C0663246", "name": "C0663246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705143", "name": "C1705143#ent", "pos": [10, 11]}}
{"token": ["These", "data", "suggest", "that", "a", "spectrum", "of", "C0016977#ent", "<e1>", "in", "which", "bile", "saturation", "gallbladder", "dysmotility", "to", "crystal", "growth", "subsequent", "C0008350#ent", "<e2>", "formation", "and", "chronic", "inflammation"], "h": {"id": "C0016977", "name": "C0016977#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008350", "name": "C0008350#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "report", "that", "a", "large", "number", "of", "hair", "cells", "produced", "in", "the", "sensory", "epithelium", "cultured", "adult", "rat", "utricular", "maculae", "via", "adenovirus-mediated", "overexpression", "of", "C1412626#ent", "<e1>", ",", "a", "human", "C3811070#ent", "<e2>"], "h": {"id": "C1412626", "name": "C1412626#ent", "pos": [24, 25]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811070", "name": "C3811070#ent", "pos": [29, 30]}}
{"token": ["C0879396#ent", "<e1>", "effectively", "inhibited", "EGFR", "and", "MAPK", "activation", "and", "C4084905#ent", "<e2>", "activity", "in", "exponentially", "growing", "cancer", "cells"], "h": {"id": "C0879396", "name": "C0879396#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [9, 10]}}
{"token": ["In", "study", "2", ",", "C1420877#ent", "<e1>", "and", "BP", "responses", "to", "C3273437#ent", "<e2>", ",", "but", "not", "AVP", ",", "were", "greater", "in", "DOCA-salt", "rats", "than", "in", "control", "rats"], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [10, 11]}}
{"token": ["Severe", "sepsis", "is", "associated", "with", "increased", "total", "peripheral", "resistance", "(", "C1420877#ent", "<e1>", ")", "and", "decreased", "organ", "blood", "flow", "in", "which", "endothelin-1", "(", "C3273437#ent", "<e2>", ")", "plays", "an", "important", "role", "."], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [22, 23]}}
{"token": ["C3a", "caused", "a", "rapid", "and", "sustained", "C4082284#ent", "<e1>", "ERK", ")", "phosphorylation", "and", "Akt", "phosphorylation", "in", "C1706333#ent", "<e2>", "mast", "cells"], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706333", "name": "C1706333#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "show", "that", "phosphorylated", "C1705446#ent", "<e1>", ",", "unlike", "non-phosphorylated", "C1705446#ent", "<e1>", ",", "is", "unable", "to", "switch", "ribosomes", "carrying", "poly(U)", "C0031460#ent", "<e1>", "in", "the", "A", "site", "to", "a", "puromycin-reactive", "state", "."], "h": {"id": "C1705446", "name": "C1705446#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031460", "name": "C0031460#ent", "pos": [20, 21]}}
{"token": ["The", "response", "requires", "caveolae", "and", "is", "initiated", "by", "endothelial", "cell", "depolarization", "K(ATP", ")", "channel", "closure", "followed", "by", "activation", "of", "NADPH", "oxidase", "C1413844#ent", "<e1>", ")", "and", "NO", "synthase", "eNOS", ")", ",", "signaling", "through", "C0752312#ent", "<e2>", "and", "endothelial", "cell", "proliferation"], "h": {"id": "C1413844", "name": "C1413844#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [32, 33]}}
{"token": ["The", "subsequent", "response", "was", "increased", "ROS", "production", "associated", "with", "activation", "of", "NADPH", "oxidase", "C1413844#ent", "<e1>", ")", "and", "then", "phosphorylation", "of", "MAP", "kinases", "C0752312#ent", "<e2>", ",", "JNK", ")", "."], "h": {"id": "C1413844", "name": "C1413844#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [22, 23]}}
{"token": ["Cytisus", "scoparius", "CS", ")", "Link", ",", "(", "Family", ":", "Leguminosae", ")", ",", "also", "called", "Sarothamnus", "scoparius", "has", "been", "shown", "in", "invitro", "experiments", "be", "endowed", "with", "C0935929#ent", "<e1>", ",", "hypnotic", "and", "C0036557#ent", "<e2>", "and", "antioxidant", "activity"], "h": {"id": "C0935929", "name": "C0935929#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0036557", "name": "C0036557#ent", "pos": [30, 31]}}
{"token": ["The", "move", "to", "Philadelphia", "in", "1884", "saw", "the", "establishment", "of", "a", "clinical", "laboratory", ",", "work", "on", "C0024530#ent", "<e1>", ",", "arsenic", "in", "anaemia", "and", "the", "C1533163#ent", "<e2>", "for", "Pepper's", "System"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1533163", "name": "C1533163#ent", "pos": [24, 25]}}
{"token": ["C1720911#ent", "<e1>", "production", "and", "C1417826#ent", "<e2>", "showed", "a", "significant", "positive", "correlation", "under", "PAR-limited", "growth", "and", "a", "significant", "negative", "correlation", "under", "PAR-saturated", "growth", "."], "h": {"id": "C1720911", "name": "C1720911#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417826", "name": "C1417826#ent", "pos": [4, 5]}}
{"token": ["Increase", "in", "the", "C0403824#ent", "<e1>", "and", "tubular", "blockage", "was", "detected", "in", "the", "PP", "and", "C3811118#ent", "<e2>", "group", "at", "8", "and", "40", "days", "post", "injection", "."], "h": {"id": "C0403824", "name": "C0403824#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "dihydropyridine", "derivative", "C0028127#ent", "<e1>", "and", "of", "the", "C3539995#ent", "<e2>", "on", "45Ca2", "+", "influx", "was", "determined", "in", "platelets", "in", "vitro", "on", "platelet", "aggregation", "ex", "vivo"], "h": {"id": "C0028127", "name": "C0028127#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539995", "name": "C3539995#ent", "pos": [10, 11]}}
{"token": ["The", "different", "alachlor", "and", "C0666175#ent", "<e1>", "respiration", "and", "C0524928#ent", "<e2>", "uptake", "rates", "in", "pre-treated", "solutions", "are", "related", "to", "change", "in", "the", "growth", "kinetics", "of", "P.", "putida", "."], "h": {"id": "C0666175", "name": "C0666175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [8, 9]}}
{"token": ["The", "former", "technique", "the", "expression", "of", "C1420175#ent", "<e1>", "in", "the", "different", "regions", "examined", "while", "C0020498#ent", "<e2>", "with", "a", "specific", "riboprobe", "allowed", "the", "anatomical", "localization", "of", "C1420175#ent", "<e1>", "mRNA", "."], "h": {"id": "C1420175", "name": "C1420175#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020498", "name": "C0020498#ent", "pos": [14, 15]}}
{"token": ["They", "were", "two", "intramedullary", "ependymomas", "C3", "and", "C1335834#ent", "<e1>", ",", "two", "schwannomas", "at", "the", "C6", "and", "C1367714#ent", "<e2>", "and", "one", "intradural", "meningioma", "T7", "."], "h": {"id": "C1335834", "name": "C1335834#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367714", "name": "C1367714#ent", "pos": [16, 17]}}
{"token": ["Long-term", "follow-up", "studies", "demonstrated", "that", "venous", "thromboembolism", "a", "C0022661#ent", "<e1>", "as", "the", "rate", "of", "recurrent", "C0149871#ent", "<e2>", "DVT", ")", "continuously", "increases", "after", "the", "primitive", "thrombotic", "episode", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [15, 16]}}
{"token": ["We", "report", "the", "isolation", "of", "Fusobacterium", "necrophorum", "joint", "aspirate", "a", "case", "of", "C0003869#ent", "<e1>", "which", "presented", "3", "weeks", "after", "the", "drainage", "of", "a", "C0518988#ent", "<e2>"], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0518988", "name": "C0518988#ent", "pos": [23, 24]}}
{"token": ["To", "study", "the", "effect", "of", "C0039512#ent", "<e1>", "on", "serum", "IL-1beta", "and", "TNF-alpha", "levels", "of", "C0003873#ent", "<e2>", "rats", ",", "as", "well", "as", "the", "mechanism", "of", "this", "drug", "."], "h": {"id": "C0039512", "name": "C0039512#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "patients", "with", "C4284230#ent", "<e1>", "and", "selective", "IgA", "deficiency", "an", "increased", "prevalence", "of", "C3714757#ent", "<e2>", "systemic", "lupus", "erythematosus", "Sj\u00f6gren's", "syndrome", "primary", "biliary", "cirrhosis", "while", "patients", "with", "selective", "IgA", "deficiency", "prone", "to", "developing", "seronegative", "spondylarthropathies", "including", "ankylosing", "spondylitis"], "h": {"id": "C4284230", "name": "C4284230#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [15, 16]}}
{"token": ["i", ")", "cDNA", "was", "elongated", "with", "dCMP", "or", "dTMP", "homopolymeric", "tracts", "using", "C1333243#ent", "<e1>", "EC", "2.7.7.31", ";", "nucleosidetriphosphate", ":", "C3887634#ent", "<e2>", "."], "h": {"id": "C1333243", "name": "C1333243#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887634", "name": "C3887634#ent", "pos": [19, 20]}}
{"token": ["Although", "all", "three", "C1268551#ent", "<e1>", "are", "active", "against", "Aspergillus", ",", "only", "C0537894#ent", "<e2>", "is", "presently", "approved", "for", "salvage", "therapy", "invasive", "aspergillosis"], "h": {"id": "C1268551", "name": "C1268551#ent", "pos": [3, 4]}, "relation": "chemical_structure_of", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [11, 12]}}
{"token": ["C1268551#ent", "<e1>", "such", "as", "C0537894#ent", "<e2>", "represent", "the", "newest", "class", "of", "antifungals", "that", "target", "cell", "wall", "synthesis", "."], "h": {"id": "C1268551", "name": "C1268551#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [4, 5]}}
{"token": ["The", "present", "study", "sought", "to", "further", "investigate", "the", "C0242912#ent", "<e1>", "action", "of", "C0005320#ent", "<e2>", "in", "the", "rat", "retina"], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005320", "name": "C0005320#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "the", "ability", "to", "confer", "C0242912#ent", "<e1>", "to", "retinal", "neurones", "a", "common", "feature", "of", "three", "ophthalmic", "beta-adrenoceptor", "antagonists", "C0005320#ent", "<e2>", ",", "metipranolol", "and", "timolol", ")", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005320", "name": "C0005320#ent", "pos": [20, 21]}}
{"token": ["By", "using", "this", "characteristic", "of", "RNAi", ",", "we", "attempted", "to", "generate", "C0040963#ent", "<e1>", "mutants", "in", "mammalian", "cells", "were", "able", "to", "successfully", "generate", "C0040963#ent", "<e1>", "mutants", "of", "cell", "cycle", "regulator", "cdc2", "and", "C1452523#ent", "<e1>"], "h": {"id": "C0040963", "name": "C0040963#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1452523", "name": "C1452523#ent", "pos": [31, 32]}}
{"token": ["Significant", "additional", "bronchodilation", "achieved", "with", "salbutamol", "and", "C0700580#ent", "<e1>", "indicates", "that", "there", "is", "likely", "a", "substantial", "cholinergic", "element", "the", "C0006266#ent", "<e2>", "observed", "in", "acute", "exacerbations", "asthma", "in", "the", "pediatric", "age", "group", "."], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [19, 20]}}
{"token": ["Interaction", "of", "C1871221#ent", "<e1>", "with", "a", "CRM1", "complex", "in", "vitro", "enhanced", "by", "incubation", "with", "C1413098#ent", "<e2>", "."], "h": {"id": "C1871221", "name": "C1871221#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413098", "name": "C1413098#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "a", "multigene", "family", "C1366882#ent", "<e1>", ")", "encoding", "protein", "kinases", "have", "the", "capacity", "to", "convert", "C0033681#ent", "<e2>", "serine/threonine", "phosphorylation", "signals", "has", "been", "identified", "in", "animal", "and", "yeast", "cells"], "h": {"id": "C1366882", "name": "C1366882#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [17, 18]}}
{"token": ["Relief", "of", "dyspnoea", "or", "C0019079#ent", "<e1>", ",", "as", "a", "result", "of", "C0024117#ent", "<e2>", "was", "the", "most", "common", "indication", "for", "therapy", "(", "20/34", ")", "."], "h": {"id": "C0019079", "name": "C0019079#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [11, 12]}}
{"token": ["However", ",", "horses", "that", "C0019079#ent", "<e1>", "were", "very", "likely", "to", "have", "had", "lower", "C0024117#ent", "<e2>", "more", "than", "one", "month", "."], "h": {"id": "C0019079", "name": "C0019079#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [13, 14]}}
{"token": ["In", "1981", ",", "4", "C4048284#ent", "<e1>", "were", "among", "the", "25", "highest", "ranking", "drugs", "in", "the", "C1424298#ent", "<e2>", "according", "to", "total", "number", "of", "prescriptions", "."], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424298", "name": "C1424298#ent", "pos": [15, 16]}}
{"token": ["TM-4", "is", "produced", "from", "the", "TM-4", "gene", ",", "and", "TMs", "2", "3", ",", "5a", ",", "and", "C0537987#ent", "<e1>", "are", "the", "products", "of", "the", "C1537647#ent", "<e2>"], "h": {"id": "C0537987", "name": "C0537987#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1537647", "name": "C1537647#ent", "pos": [23, 24]}}
{"token": ["These", "data", "demonstrate", "that", "C0267963#ent", "<e1>", "is", "a", "useful", "tool", "to", "verify", "setup", "reproducibility", "in", "C1537618#ent", "<e2>", "for", "breast", "cancer"], "h": {"id": "C0267963", "name": "C0267963#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1537618", "name": "C1537618#ent", "pos": [15, 16]}}
{"token": ["Our", "findings", "indicate", "the", "inhaled", "route", "as", "the", "most", "effective", "route", "for", "administration", "of", "C0543495#ent", "<e1>", "to", "treat", "C0006266#ent", "<e2>", "children", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [14, 15]}, "relation": "may_prevent", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [18, 19]}}
{"token": ["Remission", "was", "defined", "as", "clinical", "and", "laboratorial", "signs", "of", "C0001623#ent", "<e1>", "period", "of", "glucocorticoid", "dependence", "serum", "cortisol", "suppression", "on", "oral", "1-mg", "C0011777#ent", "<e2>", "overnight", "suppression", "test", "clinical", "remission", "hypercortisolism", "."], "h": {"id": "C0001623", "name": "C0001623#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [21, 22]}}
{"token": ["Genes", "found", "to", "be", "specifically", "upregulated", "in", "a", "p53-dependent", "manner", "included", "C0009985#ent", "<e1>", "ICErel-II", "cysteine", "protease", "macrophage", "inhibitory", "cytokine-1", "also", "known", "as", "placental", "transforming", "growth", "factor", "beta", ",", "C1419786#ent", "<e2>", ",", "and", "Waf1/p21", "."], "h": {"id": "C0009985", "name": "C0009985#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419786", "name": "C1419786#ent", "pos": [28, 29]}}
{"token": ["Chinese", "hamster", "cells", "treated", "with", "inhibitor", "of", "DNA", "synthesis", "C0020402#ent", "<e1>", "or", "arabinoside-cytesine", ")", "in", "C0221777#ent", "<e2>", "concentrations", "for", "20", "hours", "in", "the", "presence", "or", "absence", "of", "caffeine", "(", "2", "mM", ")", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0221777", "name": "C0221777#ent", "pos": [15, 16]}}
{"token": ["Some", "of", "these", "species", "of", "mycoplasma", "are", "highly", "pathogenic", ",", "causing", "C0012634#ent", "<e1>", "of", "major", "importance", ",", "namely", ",", "C0032243#ent", "<e2>", "contagious", "caprine", "pleuropneumonia", "contagious", "agalactia", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032243", "name": "C0032243#ent", "pos": [19, 20]}}
{"token": ["We", "tried", "to", "exclude", "most", "patients", "with", "prior", "C0012634#ent", "<e1>", "associated", "with", "loss", "of", "C1861821#ent", "<e2>", "or", "posterior", "capsule", "integrity", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1861821", "name": "C1861821#ent", "pos": [14, 15]}}
{"token": ["Although", "C0586989#ent", "<e1>", "pregnant", "women", "an", "uncommon", "complication", ",", "the", "C0265374#ent", "<e2>", "may", "result", "can", "be", "devastating", "."], "h": {"id": "C0586989", "name": "C0586989#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0265374", "name": "C0265374#ent", "pos": [10, 11]}}
{"token": ["Infection", "with", "the", "C0586989#ent", "<e1>", "pregnancy", "can", "produce", "an", "C0265374#ent", "<e2>", "characterized", "by", "limb", "hypoplasia", "eye", "and", "brain", "damage", "and", "skin", "lesions"], "h": {"id": "C0586989", "name": "C0586989#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0265374", "name": "C0265374#ent", "pos": [9, 10]}}
{"token": ["We", "determined", "whether", "a", "C0597979#ent", "<e1>", "and", "an", "aminoglycoside", "have", "efficacy", "greater", "than", "a", "C0597979#ent", "<e1>", "alone", "in", "the", "management", "of", "a", "pulmonary", "exacerbation", "patients", "with", "C0010674#ent", "<e1>"], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [26, 27]}}
{"token": ["A", "murine", "monoclonal", "anti-chromosomal", "beta-lactamase", "antibody", "was", "developed", "and", "an", "immunoblotting", "technique", "used", "to", "study", "the", "presence", "of", "serum", "and", "sputum", "antibodies", "Pseudomonas", "aeruginosa", "chromosomal", "group", "C0597979#ent", "<e1>", "in", "patients", "with", "C0010674#ent", "<e2>", "CF", ")", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [31, 32]}}
{"token": ["This", "allows", "immunity", "to", "C1299919#ent", "<e1>", "to", "develop", "in", "the", "presence", "of", "C0013227#ent", "<e2>", "."], "h": {"id": "C1299919", "name": "C1299919#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["We", "used", "a", "conditional", "approach", "mice", "expressing", "C1744318#ent", "<e1>", "the", "control", "of", "C1334882#ent", "<e2>", "regulatory", "sequences", "delete", "Sox9", "from", "the", "developing", "prostate", "."], "h": {"id": "C1744318", "name": "C1744318#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334882", "name": "C1334882#ent", "pos": [12, 13]}}
{"token": ["injection", "of", "C2697656#ent", "<e1>", "on", "the", "C1706468#ent", "<e2>", "mRNA", "levels", "in", "the", "Arc", "were", "significantly", "attenuated", "by", "pretreatment", "with", "i.p", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706468", "name": "C1706468#ent", "pos": [6, 7]}}
{"token": ["injection", "of", "lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "also", "caused", "a", "marked", "increase", "of", "C1706468#ent", "<e2>", "gene", "expression", "the", "PP", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706468", "name": "C1706468#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "the", "Schwann", "cell", "protein", "peripheral", "myelin", "protein", "22", "C2700453#ent", "<e1>", ")", "has", "been", "implicated", "in", "the", "molecular", "pathogenesis", "C0598589#ent", "<e2>", "mice", "and", "humans", "."], "h": {"id": "C2700453", "name": "C2700453#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0598589", "name": "C0598589#ent", "pos": [20, 21]}}
{"token": ["Previous", "studies", "have", "revealed", "that", "activation", "of", "the", "G(q)-coupled", "metabotropic", "glutamate", "receptor", "5", "C1333712#ent", "<e1>", ")", "induces", "phosphorylation", "of", "the", "C0170168#ent", "<e2>", "ERK2", ")", "in", "cultured", "rat", "cortical", "astrocytes", "."], "h": {"id": "C1333712", "name": "C1333712#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [20, 21]}}
{"token": ["Previous", "studies", "have", "revealed", "that", "activation", "of", "the", "C1333712#ent", "<e1>", "mGluR5", ")", "induces", "phosphorylation", "of", "the", "C0170168#ent", "<e2>", "ERK2", ")", "in", "cultured", "rat", "cortical", "astrocytes", "."], "h": {"id": "C1333712", "name": "C1333712#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [16, 17]}}
{"token": ["Based", "on", "microangiopathic", "hemolytic", "anemia", "C0040034#ent", "<e1>", "and", "neurological", "abnormality", "a", "clinical", "diagnosis", "C1268935#ent", "<e2>", "was", "made", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1268935", "name": "C1268935#ent", "pos": [13, 14]}}
{"token": ["C0040034#ent", "<e1>", ")", "is", "a", "multisystem", "disorders", "characterized", "by", "thrombocytopenia", ",", "C1268935#ent", "<e2>", "associated", "with", "red", "cell", "fragmentation", "and", "neurological", "and", "renal", "symptoms"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1268935", "name": "C1268935#ent", "pos": [11, 12]}}
{"token": ["Membranes", "of", "mammary", "epithelial", "cells", "Agpat6-deficient", "mice", "exhibited", "markedly", "reduced", "C1418780#ent", "<e1>", "activity", "compared", "with", "membranes", "from", "C2987364#ent", "<e2>"], "h": {"id": "C1418780", "name": "C1418780#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [17, 18]}}
{"token": ["It", "is", "possible", "that", "increases", "in", "serum", "troponin", "from", "baseline", "in", "patients", "with", "C0035078#ent", "<e1>", "admitted", "to", "hospital", "with", "acute", "coronary", "syndrome", "signify", "C1442837#ent", "<e2>"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1442837", "name": "C1442837#ent", "pos": [23, 24]}}
{"token": ["The", "C1839576#ent", "<e1>", "values", "of", "pirenzepine", "and", "C0076066#ent", "<e2>", "against", "the", "inhibitory", "responses", "of", "the", "rabbit", "vas", "deferens", "consistent", "with", "involvement", "of", "M1", "receptors"], "h": {"id": "C1839576", "name": "C1839576#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0076066", "name": "C0076066#ent", "pos": [7, 8]}}
{"token": ["C0035086#ent", "<e1>", "common", "in", "patients", "with", "C0008312#ent", "<e2>", "PBC", ")", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [6, 7]}}
{"token": ["C0035086#ent", "<e1>", "a", "frequently", "reported", "complication", "in", "primary", "biliary", "cirrhosis", "C0008312#ent", "<e2>", ")", ",", "but", "its", "pathogenesis", "is", "poorly", "understood", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [10, 11]}}
{"token": ["The", "inhibition", "of", "voltage-dependent", "Ca(2+)", "channel", "C0033681#ent", "<e1>", "and", "alleviation", "of", "C0001477#ent", "<e2>", "from", "sarcoplasmic", "reticulum", "SR", ")", "are", "possibly", "involved", "in", "the", "effects", "of", "resveratrol", "on", "rat", "ventricular", "myocytes"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "sevoflurane", "increases", "glucose", "uptake", "skeletal", "muscle", "cells", "that", "the", "sevoflurane-stimulated", "glucose", "uptake", "was", "associated", "with", "C0033681#ent", "<e1>", "protein", "kinase", "C", "and", "intracellular", "C0001477#ent", "<e2>"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [25, 26]}}
{"token": ["We", "conducted", "a", "single-dose", "study", "to", "evaluate", "the", "effect", "of", "candesartan", "C0527379#ent", "<e1>", "on", "cardiac", "hemodynamics", "hormone", "response", "13", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0527379", "name": "C0527379#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["C1417500#ent", "<e1>", "+", "and", "Mn2", "+", "dose-dependently", "increased", "C0031640#ent", "<e2>", "activity", "and", "reversed", "the", "inactivating", "effect", "of", "EDTA.h6.1", "was", "engineered", "to", "express", "a", "C-terminal", "five-histidine", "motif", "(", "h6.1his5", ")", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [8, 9]}}
{"token": ["The", "results", "indicated", "that", "C1417500#ent", "<e1>", "+", "-ATPase", "and", "possibly", "C0031640#ent", "<e2>", "associated", "with", "plasma", "membrane"], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [10, 11]}}
{"token": ["We", "demonstrated", "high", "C1425016#ent", "<e1>", "expression", "in", "liver", ",", "kidney", "and", "testis", ";", "C1417879#ent", "<e2>", "expression", "is", "primarily", "restricted", "to", "the", "brain", "."], "h": {"id": "C1425016", "name": "C1425016#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417879", "name": "C1417879#ent", "pos": [13, 14]}}
{"token": ["The", "binding", "sites", "Ca2", "+", "C0006684#ent", "<e1>", "probed", "using", "C0053030#ent", "<e2>", "2-iodoethyl", "isopropyl", "1,4-dihydropyridine-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarbox", "ylate", "]", "that", "has", "been", "radiolabelled", "with", "125I", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0053030", "name": "C0053030#ent", "pos": [9, 10]}}
{"token": ["We", "engineered", "an", "MLCK", "fragment", "containing", "the", "C1416810#ent", "<e1>", "devoid", "of", "a", "catalytic", "domain", "explore", "how", "C0027096#ent", "<e2>", "is", "stimulated", "by", "this", "non-kinase", "pathway", "."], "h": {"id": "C1416810", "name": "C1416810#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [16, 17]}}
{"token": ["The", "main", "etiologies", "are", ":", "C0878544#ent", "<e1>", "with", "heart", "rate", "troubles", "hematologic", "diseases", "major", "form", "of", "C0005283#ent", "<e2>", ")", ",", "twins", "pregnancies", "but", "the", "list", "of", "the", "causes", "is", "very", "long", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [16, 17]}}
{"token": ["The", "Mirizzi", "syndrome", "an", "unusual", "benign", "C0022346#ent", "<e1>", "to", "extrinsic", "mechanical", "compression", "the", "common", "hepatic", "duct", "C0947622#ent", "<e2>", "impacted", "within", "the", "neck", "or", "cystic", "duct", "the", "gallbladder", "."], "h": {"id": "C0022346", "name": "C0022346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [16, 17]}}
{"token": ["The", "Mirizzi", "syndrome", "an", "uncommon", "condition", "of", "C0022346#ent", "<e1>", "secondary", "to", "common", "hepatic", "duct", "obstruction", "caused", "by", "a", "C0947622#ent", "<e2>", "impacted", "in", "the", "gallbladder", "'s", "infundibulum", "."], "h": {"id": "C0022346", "name": "C0022346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [18, 19]}}
{"token": ["The", "in", "vitro", "of", "C0052432#ent", "<e1>", ",", "the", "antimalarial", "agent", "and", "C0025872#ent", "<e2>", "against", "Acanthamoeba", "spp", "studied", "."], "h": {"id": "C0052432", "name": "C0052432#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [11, 12]}}
{"token": ["Dll3", "does", "not", "compensate", "for", "Dll1", ";", "C1414070#ent", "<e1>", "activates", "Notch", "in", "Drosophila", "wing", "discs", ",", "but", "C1414071#ent", "<e2>", "does", "not", "."], "h": {"id": "C1414070", "name": "C1414070#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414071", "name": "C1414071#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", "to", "endogenous", "C1414070#ent", "<e1>", "located", "on", "the", "surface", "of", "presomitic", "mesoderm", "cells", "we", "find", "endogenous", "C1414071#ent", "<e2>", "predominantly", "in", "the", "Golgi", "apparatus"], "h": {"id": "C1414070", "name": "C1414070#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414071", "name": "C1414071#ent", "pos": [17, 18]}}
{"token": ["LH", "retarded", "structural", "development", "reduced", "tropoelastin", "mRNA", "levels", ",", "reduced", "hydroxyproline", "and", "C0013765#ent", "<e1>", "contents", ",", "and", "increased", "C0172537#ent", "<e2>", "MMP-2", ")", "levels", "in", "the", "fetal", "lung", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [18, 19]}}
{"token": ["Since", "aspartic", "proteinases", "play", "major", "roles", "in", "C0268407#ent", "<e1>", "malaria", "and", "common", "C0026946#ent", "<e2>", "as", "candidiasis", ",", "inhibitors", "to", "these", "enzymes", "are", "much", "sought", "after", "as", "potential", "therapeutic", "agents"], "h": {"id": "C0268407", "name": "C0268407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [12, 13]}}
{"token": ["Mitochondrial", "content", "C0010760#ent", "<e1>", "ATP", "synthase", "phosphate", "and", "adenine", "nucleotide", "carriers", "were", "increased", "in", "C3831153#ent", "<e2>", "and", "decreased", "in", "hypothyroidism", "as", "compared", "to", "controls", "."], "h": {"id": "C0010760", "name": "C0010760#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [14, 15]}}
{"token": ["The", "options", "available", "for", "the", "treatment", "of", "acute", "attacks", "C0018099#ent", "<e1>", "are", "NSAIDs", ",", "C0009262#ent", "<e2>", ",", "corticosteroids", ",", "corticotropin", "and", "intra-articular", "corticosteroids"], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [14, 15]}}
{"token": ["Ryanodine", ",", "TMB-8", ",", "lidoflazine", "and", "C0770909#ent", "<e1>", ",", "applied", "at", "the", "EC50", ",", "displaced", "the", "concentration-response", "curves", "C2936886#ent", "<e2>", "and", "monensin", "to", "the", "right", "but", "reduced", "the", "maximal", "increase", "of", "the", "left", "ventricular", "pressure"], "h": {"id": "C0770909", "name": "C0770909#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [18, 19]}}
{"token": ["Since", "the", "latter", "effect", "could", "be", "due", "to", "an", "inhibition", "of", "calcium", "release", "intracellular", "compartments", "it", "was", "investigated", "how", "C0770909#ent", "<e1>", "influences", "the", "effect", "of", "C2936886#ent", "<e2>", "on", "functionally", "isolated", "contractile", "structures"], "h": {"id": "C0770909", "name": "C0770909#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [25, 26]}}
{"token": ["These", "results", "suggest", "that", "C0770909#ent", "<e1>", "binds", "to", "calmodulin", "in", "the", "presence", "of", "C2936886#ent", "<e2>", "and", "potently", "inhibits", "the", "phosphorylation", "of", "myosin", "light", "chain"], "h": {"id": "C0770909", "name": "C0770909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [13, 14]}}
{"token": ["During", "the", "past", "decade", ",", "C0812228#ent", "<e1>", "(", "also", "known", "as", "C0285558#ent", "<e2>", "PKB", ")", "has", "been", "extensively", "studied", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [11, 12]}}
{"token": ["Seven", "women", "with", "C0002453#ent", "<e1>", "hyperprolactinaemia", "were", "treated", "with", "C0006230#ent", "<e2>", "."], "h": {"id": "C0002453", "name": "C0002453#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [9, 10]}}
{"token": ["This", "study", "included", "a", "group", "of", "50", "women", "with", "C0002453#ent", "<e1>", "who", "were", "treated", "with", "C0006230#ent", "<e2>", "(", "2-bromo-alpha-ergocryptine", ")", "."], "h": {"id": "C0002453", "name": "C0002453#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [15, 16]}}
{"token": ["All", "8", "patients", "with", "C0002453#ent", "<e1>", "who", "were", "treated", "either", "primarily", "or", "secondarily", "with", "C0006230#ent", "<e2>", "ovulated", ",", "and", "4", "conceived", "."], "h": {"id": "C0002453", "name": "C0002453#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [14, 15]}}
{"token": ["Guanylyl", "imidodiphosphate", "GMP-PNP", ")", "C0033993#ent", "<e1>", "enzyme", "activity", "a", "means", "of", "detecting", "C0018358#ent", "<e2>", "demonstrated", "in", "osteoblasts", "of", "chicken", "tibial", "metaphysis", "using", "a", "lead", "citrate", "histochemical", "method", "at", "the", "electron", "microscopic", "."], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018358", "name": "C0018358#ent", "pos": [12, 13]}}
{"token": ["Expression", "of", "C1413815#ent", "<e1>", "MMP-9", ",", "and", "TRAP", "relative", "to", "C1367028#ent", "<e2>", "was", "significantly", "higher", "in", "the", "osteoarthritic", "group"], "h": {"id": "C1413815", "name": "C1413815#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1367028", "name": "C1367028#ent", "pos": [10, 11]}}
{"token": ["The", "pansclerotic", "PCT", "was", "differentiated", "from", "a", "C0036421#ent", "<e1>", "a", "disabling", "C3897992#ent", "<e2>", "a", "generalized", "morphea", "means", "of", "histological", "examinations", "the", "absence", "of", "a", "Raynaud", "phenomenon", "and", "the", "non-involvement", "of", "additional", "organs", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3897992", "name": "C3897992#ent", "pos": [11, 12]}}
{"token": ["In", "this", "regard", ",", "however", ",", "EF", "more", "closely", "resembles", "the", "C0036421#ent", "<e1>", "especially", "morphea", "profunda", "and", "C3897992#ent", "<e2>"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3897992", "name": "C3897992#ent", "pos": [17, 18]}}
{"token": ["These", "experiments", "reveal", "that", "the", "functional", "interplay", "between", "C1417708#ent", "<e1>", "and", "the", "C1705401#ent", "<e2>", "also", "involves", "--", "dependent", "on", "the", "promoter", "context", "--", "synergistic", "stimulation", "of", "transcription", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [12, 13]}}
{"token": ["The", "presence", "of", "only", "one", "GRE", "in", "the", "vicinity", "of", "the", "KB", "sites", "abolished", "this", "repression", "and", "allowed", "synergistic", "transcriptional", "activation", "C1417708#ent", "<e1>", "and", "the", "glucocorticoid", "receptor", "C1705401#ent", "<e2>", ")", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [27, 28]}}
{"token": ["These", "results", "suggested", "that", "the", "abnormal", "activation", "of", "C1417708#ent", "<e1>", "and", "AP-1", "and", "the", "reduction", "of", "C1705401#ent", "<e2>", "DNA-binding", "abilities", "may", "be", "involved", "in", "the", "pathogenesis", "of", "MCNS", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [16, 17]}}
{"token": ["In", "the", "two", "C0017337#ent", "<e1>", "belonging", "to", "the", "C3494445#ent", "<e2>", "we", "identified", "9", "SNPs", ",", "7", "of", "them", "novel", ",", "for", "ARD1", ",", "and", "six", "novel", "SNPs", "for", "L1CAM", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3494445", "name": "C3494445#ent", "pos": [8, 9]}}
{"token": ["Stockman", "in", "1895", "proposed", "that", "C0008272#ent", "<e1>", "was", "the", "result", "of", "a", "C0162429#ent", "<e2>", "but", "his", "view", "was", "largely", "ignored", "for", "decades", "."], "h": {"id": "C0008272", "name": "C0008272#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [12, 13]}}
{"token": ["From", "his", "chemical", "determination", "copper", "in", "red", "blood", "cells", "1848", ",", "Millon", "proposed", "a", "form", "of", "C0008272#ent", "<e1>", "due", "to", "C0162429#ent", "<e2>"], "h": {"id": "C0008272", "name": "C0008272#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [20, 21]}}
{"token": ["The", "homozygous", "C0022346#ent", "<e1>", "Gunn", "rat", "expression", "of", "bilirubin", "UDP-glucuronosyltransferase", "serves", "as", "a", "model", "for", "C2931132#ent", "<e2>", "in", "which", "high", "and", "toxic", "plasma", "of", "bilirubin", "result", "from", "this", "genetic", "defect", "bilirubin", "conjugation"], "h": {"id": "C0022346", "name": "C0022346#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C2931132", "name": "C2931132#ent", "pos": [15, 16]}}
{"token": ["The", "potential", "caveolin-1", "binding", "domain", "CBD", ")", ",", "referred", "to", "as", "CBD1", "and", "CBD2", ",", "is", "highly", "conserved", "in", "the", "C1415205#ent", "<e1>", "various", "HIV-1", "and", "HIV-2", "C1875400#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1415205", "name": "C1415205#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [26, 27]}}
{"token": ["C1309116#ent", "<e1>", "a", "novel", "C0030956#ent", "<e2>", "purified", "to", "homogeneity", "from", "rat", "and", "human", "brain", "."], "h": {"id": "C1309116", "name": "C1309116#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}}
{"token": ["We", "have", "studied", "a", "family", "with", "classical", "C0005129#ent", "<e1>", ",", "and", "have", "excluded", "lesions", "at", "the", "C4281938#ent", "<e2>", "restriction", "fragment", "polymorphism", "linkage", "analysis", "."], "h": {"id": "C0005129", "name": "C0005129#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4281938", "name": "C4281938#ent", "pos": [16, 17]}}
{"token": ["It", "has", "been", "implicated", "in", "a", "human", "C0022658#ent", "<e1>", "as", "Balkan", "C4049993#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C4049993", "name": "C4049993#ent", "pos": [11, 12]}}
{"token": ["C0102118#ent", "<e1>", "(", "ALN", ")", "is", "an", "C0012544#ent", "<e2>", "employed", "as", "an", "antiresorptive", "agent", "in", "the", "treatment", "of", "osteoporosis", "."], "h": {"id": "C0102118", "name": "C0102118#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [7, 8]}}
{"token": ["C0028928#ent", "<e1>", "to", "the", "medium", "stimulates", "TG", "and", "C1416804#ent", "<e2>", "secretion", "in", "a", "similar", "way", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [8, 9]}}
{"token": ["Although", "C0028928#ent", "<e1>", "increases", "both", "the", "secretion", "of", "triglycerides", "and", "C1416804#ent", "<e2>", "by", "primary", "rat", "hepatocytes", ",", "the", "effect", "of", "other", "fatty", "acids", "FA", ")", "on", "C1416804#ent", "<e2>", "secretion", "is", "not", "known", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [10, 11]}}
{"token": ["Treatment", "with", "C0028928#ent", "<e1>", "in", "a", "1.5-fold", "increase", "in", "hepatocyte", "C1416804#ent", "<e2>", "mRNA", "accumulation", ",", "whereas", "butyrate", "and", "palmitate", "had", "no", "effect"], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [10, 11]}}
{"token": ["A", "7", "year", "old", "girl", "with", "C0014544#ent", "<e1>", "and", "spastic", "quadriplegia", "secondary", "to", "episode", "of", "C0038220#ent", "<e2>", "4", "months", "of", "age", "is", "reported", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [15, 16]}}
{"token": ["The", "lumbar", "cerebrospinal", "fluid", "CSF", ")", "gamma-aminobutyric", "acid", "GABA", ")", "levels", "were", "measured", "in", "27", "patients", "with", "C0014544#ent", "<e1>", ",", "another", "three", "epileptic", "patients", "with", "C0038220#ent", "<e2>", "three", "epileptic", "patients", "with", "chronic", "cerebellar", "ataxia"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [25, 26]}}
{"token": ["The", "arylhydrocarbon", "receptor", "C1706481#ent", "<e1>", ")", "functions", "as", "a", "ligand-activated", "transcription", "factor", "regulates", "the", "transcription", "of", "C0017337#ent", "<e2>", "encoding", "xenobiotic", "metabolizing", "and", "also", "mediates", "most", "of", "the", "toxic", "effects", "by", "dioxins", "and", "polycyclic", "aromatic", "hydrocarbons"], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["Aryl", "hydrocarbon", "receptor", "C1706481#ent", "<e1>", ")", "is", "a", "ligand-activated", "transcription", "factor", "regulates", "C0017337#ent", "<e2>", "involved", "in", "xenobiotic", "metabolism", "cellular", "proliferation", "and", "differentiation", "."], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["We", "concluded", "that", "C0033215#ent", "<e1>", "decreased", "plasma", "LDL1", ",", "C1422484#ent", "<e2>", "and", "HDL3", "amounts", "and", "made", "them", "triglyceride-rich", "with", "the", "concomitant", "increase", "of", "CETP", "activities", "."], "h": {"id": "C0033215", "name": "C0033215#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422484", "name": "C1422484#ent", "pos": [9, 10]}}
{"token": ["Preliminary", "reports", "support", "the", "use", "of", "add-on", "C0076829#ent", "<e1>", "in", "adults", "with", "generalised", "epilepsy", "in", "childhood", "epilepsies", "in", "patients", "with", "C0238111#ent", "<e2>", "as", "well", "as", "the", "use", "of", "C0076829#ent", "<e1>", "monotherapy", "in", "patients", "with", "partial", "epilepsy"], "h": {"id": "C0076829", "name": "C0076829#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [20, 21]}}
{"token": ["The", "response", "to", "topiramate", "(", "C0076829#ent", "<e1>", ")", "as", "long-term", "adjunctive", "therapy", "evaluated", "in", "patients", "with", "Lennox-Gastaut", "syndrome", "C0238111#ent", "<e2>", ")", "in", "a", "long-term", ",", "open-label", "extension", "to", "a", "double-blind", ",", "placebo-controlled", "trial"], "h": {"id": "C0076829", "name": "C0076829#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [18, 19]}}
{"token": ["C0020404#ent", "<e1>", ",", "an", "effective", "but", "sedating", "C0019592#ent", "<e2>", "is", "given", "orally", "to", "treat", "allergic", "skin", "disorders"], "h": {"id": "C0020404", "name": "C0020404#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019592", "name": "C0019592#ent", "pos": [7, 8]}}
{"token": ["Cetirizine", ",", "a", "derivative", "of", "C0020404#ent", "<e1>", ",", "is", "a", "new", "compound", "with", "potent", "C0019592#ent", "<e2>", "property", "without", "antiserotonin", "and", "anticholinergic", "activities"], "h": {"id": "C0020404", "name": "C0020404#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019592", "name": "C0019592#ent", "pos": [14, 15]}}
{"token": ["A", "compound", "score", "reflecting", "the", "balance", "between", "peripheral", "and", "CNS", "effects", ",", "showed", "C0020404#ent", "<e1>", "to", "have", "relatively", "more", "peripheral", "C0019592#ent", "<e2>", "effect", "and", "less", "sedative", "effect", "the", "other", "two", "drugs", "."], "h": {"id": "C0020404", "name": "C0020404#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019592", "name": "C0019592#ent", "pos": [20, 21]}}
{"token": ["The", "pulp", "extract", "effective", "in", "inducing", "GST", ",", "C1709138#ent", "<e1>", ",", "SOD", "and", "C1413138#ent", "<e2>", "as", "measured", "in", "extrahepatic", "organs"], "h": {"id": "C1709138", "name": "C1709138#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [13, 14]}}
{"token": ["Indomethacin", "was", "used", "for", "the", "examination", "of", "adhesion", ",", "C0012381#ent", "<e1>", "for", "the", "study", "of", "friction", ",", "and", "C0025872#ent", "<e2>", "for", "the", "determination", "of", "the", "spreading", "coefficient"], "h": {"id": "C0012381", "name": "C0012381#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [18, 19]}}
{"token": ["Purified", "FMO", "from", "rat", "liver", "was", "used", "to", "study", "the", "enantioselectivity", "of", "this", "C0014442#ent", "<e1>", "in", "the", "sulfoxidation", "of", "C0001911#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001911", "name": "C0001911#ent", "pos": [19, 20]}}
{"token": ["We", "evaluated", "126", "patients", "with", "inducible", "sustained", "ventricular", "tachyarrhythmias", "assess", "whether", "the", "response", "to", "C0033216#ent", "<e1>", "during", "electrophysiologic", "study", "predict", "responses", "to", "other", "conventional", "C0003195#ent", "<e2>", "combinations", "of", "agents", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [14, 15]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [24, 25]}}
{"token": ["C0033216#ent", "<e1>", "is", "used", "in", "C0003195#ent", "<e2>", "and", "the", "need", "to", "monitor", "the", "drug", "concentration", "well", "as", "its", "major", "plasma", "metabolite", "N-acetyl-procainamide", ",", "is", "well", "established", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [5, 6]}}
{"token": ["Incubation", "of", "the", "recombinant", "C0057968#ent", "<e1>", "with", "the", "catalytic", "subunit", "the", "C0010531#ent", "<e2>", "a", "cell-free", "system", "the", "phosphorylation", "and", "activation", "of", "the", "ratPDE3.3", "protein", "variant", "."], "h": {"id": "C0057968", "name": "C0057968#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [11, 12]}}
{"token": ["C0025942#ent", "<e1>", "oral", "gel", "frequently", "prescribed", "for", "the", "treatment", "of", "oral", "C0006846#ent", "<e2>"], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0006846", "name": "C0006846#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "following", "in", "vivo", "perfusion", "of", "equimolar", "amounts", "of", "amino", "acid", "C0281255#ent", "<e1>", ")", "and", "dipeptide", "(", "C0064819#ent", "<e2>", "through", "bypassed", "jejunal", "segments", "the", "uptake", "of", "C0281255#ent", "<e1>", "was", "determined", "."], "h": {"id": "C0281255", "name": "C0281255#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0064819", "name": "C0064819#ent", "pos": [19, 20]}}
{"token": ["On", "the", "other", "hand", ",", "in", "the", "rats", "treated", "with", "anti-oxidants", "and", "Cd", ",", "serum", "C0242192#ent", "<e1>", "and", "ALT", ",", "liver", "glutathione", "C1416903#ent", "<e2>", "levels", "decreased", "."], "h": {"id": "C0242192", "name": "C0242192#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1416903", "name": "C1416903#ent", "pos": [22, 23]}}
{"token": ["These", "manifestations", "include", "a", "viral", "prodrome", "with", "a", "serum", "sickness-like", "syndrome", ",", "C0343190#ent", "<e1>", "glomerulonephritis", ",", "as", "well", "as", "various", "neurological", "and", "C0018939#ent", "<e2>", "other", "manifestations", "."], "h": {"id": "C0343190", "name": "C0343190#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [22, 23]}}
{"token": ["GST", "(", "glutathione", "transferase", "pull-down", "experiments", "confirmed", "that", "the", "C-terminal", "tail", "C1424559#ent", "<e1>", "coprecipitates", "with", "the", "scaffold", "protein", "C3810601#ent", "<e2>", "as", "identified", "byMS", "."], "h": {"id": "C1424559", "name": "C1424559#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3810601", "name": "C3810601#ent", "pos": [18, 19]}}
{"token": ["Our", "data", "suggest", "that", "cyclic", "stretch", "activates", "the", "phosphoinositide", "3-kinase", "PI3", "K", ")", "pathway", "including", ":", "C1705325#ent", "<e1>", "Akt", ",", "FKHR", ",", "and", "C1704966#ent", "<e2>", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704966", "name": "C1704966#ent", "pos": [23, 24]}}
{"token": ["The", "majority", "of", "patients", "with", "connective", "tissue", "disorder", "extra-neurological", "manifestations", "C0151445#ent", "<e1>", "phenomenon", ",", "arthritis", ",", "C0263401#ent", "<e2>", "purpura", "and", "presence", "of", "multiple", "autoantibodies", "their", "sera", "."], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0263401", "name": "C0263401#ent", "pos": [16, 17]}}
{"token": ["The", "15", "highest", "binding", "SLE", "patients", "included", "10", "with", "C0151445#ent", "<e1>", "phenomenon", ",", "5", "with", "C0263401#ent", "<e2>", "7", "with", "vasculitis", ",", "3", "with", "major", "thrombotic", "episodes", "3", "with", "spontaneous", "abortions"], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0263401", "name": "C0263401#ent", "pos": [15, 16]}}
{"token": ["CLK1", "and", "C1413490#ent", "<e1>", "phosphorylation", "of", "C1335056#ent", "<e2>", "in", "vitro", "activated", "the", "phosphatase", "activity", "3", "-", "5-fold", "using", "either", "p-nitrophenol", "phosphate", "or", "tyrosine-phosphorylated", "myelin", "basic", "protein", "as", "substrates", "."], "h": {"id": "C1413490", "name": "C1413490#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335056", "name": "C1335056#ent", "pos": [6, 7]}}
{"token": ["Complex", "functional", "properties", "typical", "of", "cardiac", "muscle", "observed", "in", "the", "C0020352#ent", "<e1>", "cell-derived", "CMs", "including", "rate", "adaptation", "of", "AP", "C2926735#ent", "<e2>", "and", "provoked", "early", "and", "delayed", "afterdepolarizations", "."], "h": {"id": "C0020352", "name": "C0020352#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [19, 20]}}
{"token": ["C0001344#ent", "<e1>", "was", "improved", ",", "and", "in", "the", "digital", "endoscopic", "assessment", "of", "C0239295#ent", "<e2>", "complicating", "inhaled", "steroid", "therapy", "C0239295#ent", "<e2>", "Grade", "I", "mild", "grade", "."], "h": {"id": "C0001344", "name": "C0001344#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0239295", "name": "C0239295#ent", "pos": [12, 13]}}
{"token": ["C2713509#ent", "<e1>", ",", "rho", "A", ",", "and", "C3853644#ent", "<e2>", "all", "showed", "translocation", "to", "the", "cytoskeletal", "fraction", "osteoclast", "attachment", "to", "plastic", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [7, 8]}}
{"token": ["Premature", "and", "accelerated", "atherosclerosis", "can", "not", "be", "the", "sole", "cause", "of", "C3534591#ent", "<e1>", "functional", "disorders", "both", "in", "experimental", "and", "in", "C0011849#ent", "<e2>", "the", "onset", "of", "the", "detectable", "morphological", "changes", "of", "the", "vessel", "wall"], "h": {"id": "C3534591", "name": "C3534591#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [20, 21]}}
{"token": ["From", "these", "data", "we", "conclude", "that", "the", "observed", "abnormalities", "of", "in", "vitro", "fibrinolysis", "are", "not", "primarily", "associated", "with", "C3534591#ent", "<e1>", "but", "might", "be", "secondary", "to", "metabolic", "disorders", "by", "C0011849#ent", "<e2>", "."], "h": {"id": "C3534591", "name": "C3534591#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [28, 29]}}
{"token": ["C3534591#ent", "<e1>", "defined", "as", "myocardial", "disease", "patients", "with", "C0011849#ent", "<e2>", "that", "can", "not", "be", "ascribed", "to", "hypertension", ",", "coronary", "artery", "disease", "or", "other", "known", "cardiac", "disease", "is", "reviewed", "."], "h": {"id": "C3534591", "name": "C3534591#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}}
{"token": ["The", "spp1", "mutant", "displaying", "an", "aberrant", "mitotic", "phenotype", "fails", "to", "properly", "activate", "the", "C0659150#ent", "<e1>", "C1332753#ent", "<e2>", "but", "not", "the", "Cds1", "C1332753#ent", "<e2>"], "h": {"id": "C0659150", "name": "C0659150#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332753", "name": "C1332753#ent", "pos": [15, 16]}}
{"token": ["C0659150#ent", "<e1>", "is", "the", "major", "C1332753#ent", "<e2>", "the", "arrest", "of", "DNA", "polymerase", "mutants", "."], "h": {"id": "C0659150", "name": "C0659150#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332753", "name": "C1332753#ent", "pos": [5, 6]}}
{"token": ["Despite", "receiving", "appropriate", "treatment", "for", "these", "problems", ",", "the", "patients", "had", "recurrent", "episodes", "of", "C0007785#ent", "<e1>", "myocardial", "injury", "and", "a", "characteristic", "pattern", "of", "C0263401#ent", "<e2>"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0263401", "name": "C0263401#ent", "pos": [23, 24]}}
{"token": ["Neurolytic", "agents", "as", "C0070570#ent", "<e1>", "(", "5", "%", "to", "10", "%", ")", "and", "absolute", "C0001962#ent", "<e2>", "have", "long", "been", "used", "clinically", "to", "destroy", "the", "pathogenic", "nerve", "that", "manifest", "pain", "."], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [14, 15]}}
{"token": ["C0070570#ent", "<e1>", "(", "carbolic", "acid", "a", "higher", "C0001962#ent", "<e2>", ")", "has", "been", "used", "for", "local", "analgesic", "therapy", "a", "long", "time"], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [7, 8]}}
{"token": ["From", "comparative", "studies", "filaggrin", "and", "C1416524#ent", "<e1>", ",", "trichohyalin", "expression", "was", "co-localized", "with", "them", "in", "C0026393#ent", "<e2>", "keratoacanthoma", "and", "pilomatricoma", "."], "h": {"id": "C1416524", "name": "C1416524#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026393", "name": "C0026393#ent", "pos": [15, 16]}}
{"token": ["Several", "dystonias", ",", "Huntington's", "disease", "C1414474#ent", "<e1>", "various", "rare", "conditions", "are", "among", "the", "C0019247#ent", "<e2>", "disorders", "with", "considerable", "genetic", "and", "clinical", "heterogeneity", "."], "h": {"id": "C1414474", "name": "C1414474#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [13, 14]}}
{"token": ["Enzyme", "activity", "C1384672#ent", "<e1>", "concentration", "were", "analysed", "in", "patients", "with", "C0003873#ent", "<e2>", "the", "same", "plasma", "levels", "antioxidants", "(", "ascorbate", ",", "urate", ",", "alpha-tocopherol", ",", "retinol", ")", "or", "oxidation", "markers", "nitrotyrosine", ",", "lipoperoxide", ")", "of", "healthy", "subjects"], "h": {"id": "C1384672", "name": "C1384672#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "compare", "the", "activity", "of", "C0700480#ent", "<e1>", "10", "mg", "with", "that", "of", "C0171302#ent", "<e2>", "10", "mg", "vs", "placebo", "at", "24", "h", "after", "intake", "in", "healthy", "volunteers"], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0171302", "name": "C0171302#ent", "pos": [18, 19]}}
{"token": ["Loratadine", "or", "C0700480#ent", "<e1>", ",", "and", "possibly", "C0171302#ent", "<e2>", ",", "appear", "to", "be", "treatments", "of", "choice", "for", "chronic", "idiopathic", "urticaria"], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0171302", "name": "C0171302#ent", "pos": [7, 8]}}
{"token": ["We", "have", "assessed", "the", "tumorigenicity", "of", "the", "C1708843#ent", "<e1>", "allele", "by", "transfecting", "this", "C0079429#ent", "<e2>", "and", "its", "normal", "counterpart", "into", "NIH3T3", "cells", ",", "together", "with", "a", "neomycin", "resistance", "gene"], "h": {"id": "C1708843", "name": "C1708843#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["Using", "a", "cDNA", "clone", "for", "the", "transcript", "of", "the", "C1708843#ent", "<e1>", "H", "c-myc", ",", "we", "show", "that", "the", "mouse", "c-myc", "M", "c-myc", "C0079429#ent", "<e2>", "is", "contained", "within", "NIARD", "."], "h": {"id": "C1708843", "name": "C1708843#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [22, 23]}}
{"token": ["Ingestion", "of", "75", "g", "glucose", "during", "an", "oral", "glucose", "tolerance", "test", "OGTT", ")", "increases", "systemic", "inflammation", "oxidative", "stress", "healthy", "subjects", "patients", "with", "C0011860#ent", "<e1>", "but", "the", "effect", "in", "overweight/obese", "C0362046#ent", "<e2>", "individuals", "is", "uncertain", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [29, 30]}}
{"token": ["Individuals", "with", "non-insulin-dependent", "diabetes", "mellitus", "C0011860#ent", "<e1>", ")", "have", "a", "higher", "body", "mass", "index", "BMI", ")", "than", "C0362046#ent", "<e2>", "individuals", "and", "it", "has", "been", "reported", "that", "individuals", "with", "C0011860#ent", "<e1>", "have", "more", "difficulty", "losing", "excess", "weight", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [17, 18]}}
{"token": ["It", "is", "suggested", "that", "C0011860#ent", "<e1>", "in", "contrast", "to", "C0362046#ent", "<e2>", ")", "are", "more", "sensitive", "to", "the", "influence", "of", "19-norprogestogens", "than", "to", "alkylated", "estrogens", ",", "with", "respect", "to", "lipid", "metabolism"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [9, 10]}}
{"token": ["To", "study", "the", "involvement", "of", "C1423842#ent", "<e1>", "and", "Th2", "cells", "the", "initiation", "and", "progression", "of", "C3273872#ent", "<e2>", ",", "we", "targeted", "endogenous", "IL-12", "by", "administration", "of", "(p40)2", "in", "NOD", "mice", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [15, 16]}}
{"token": ["These", "results", "identify", "IA-2", "as", "an", "early", "T", "cell-inducing", "autoantigen", "in", "the", "NOD", "mouse", "and", "indicate", "a", "role", "for", "the", "IA-2-induced", "C1423842#ent", "<e1>", "cell", "response", "in", "C3273872#ent", "<e2>", "pathogenesis", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [26, 27]}}
{"token": ["Recently", ",", "we", "identified", "a", "peptide", "epitope", "Imogen", "p55", "-", "70", ")", "that", "is", "recognized", "by", "a", "38", "kD-specific", ",", "C1423842#ent", "<e1>", "clone", "from", "an", "C3273872#ent", "<e2>", "patient", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [25, 26]}}
{"token": ["Protracted", "C0170168#ent", "<e1>", "activation", "may", "contribute", "to", "C1415749#ent", "<e2>", "phosphorylation", "and", "the", "numerous", "metabolic", "alterations", "that", "constitute", "the", "heat-shock", "response"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415749", "name": "C1415749#ent", "pos": [7, 8]}}
{"token": ["To", "determine", "the", "effects", "of", "cholinesterase", "inhibition", "with", "C0771182#ent", "<e1>", "the", "symptoms", "of", "C0002395#ent", "<e2>", "terms", "of", "cognitive", "performance", "clinical", "global", "impression", "behavior", ",", "and", "functional", "autonomy", "."], "h": {"id": "C0771182", "name": "C0771182#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [13, 14]}}
{"token": ["Deficiency", "of", "the", "hepatic", "cytosolic", "enzyme", "tyrosine", "aminotransferase", "(", "TAT", ")", "causes", "marked", "C1879362#ent", "<e1>", "leading", "to", "C0030193#ent", "<e2>", "palmoplantar", "hyperkeratoses", "pseudodendritic", "keratitis", "variable", "mental", "retardation", "oculocutaneous", "tyrosinaemia", "type", "II", "Richner-Hanhart", "syndrome", "."], "h": {"id": "C1879362", "name": "C1879362#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [17, 18]}}
{"token": ["C0012634#ent", "<e1>", "to", "have", "a", "special", "impact", "on", "the", "C4255166#ent", "<e2>", "of", "autistic", "disorder", "need", "to", "be", "thoroughly", "examined", "in", "each", "child", "with", "autistic", "disorder"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4255166", "name": "C4255166#ent", "pos": [9, 10]}}
{"token": ["Ikkbeta", "deficiency", "prevented", "the", "induction", "of", "C3814151#ent", "<e1>", "and", "gadd45gamma", "by", "arsenic", ",", "whereas", "the", "induction", "of", "C1333655#ent", "<e2>", "and", "gadd153", "was", "appreciably", "enhanced", "in", "Ikkbeta-/-", "cells", "."], "h": {"id": "C3814151", "name": "C3814151#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333655", "name": "C1333655#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "C0056650#ent", "<e1>", "reacts", "with", "the", "DA", "metabolite", "C1517852#ent", "<e2>", "to", "generate", "a", "biologically", "active", "cyanohydrin", "adduct", "which", "may", "contribute", "to", "the", "neurotoxic", "response", "to", "C0056650#ent", "<e1>", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1517852", "name": "C1517852#ent", "pos": [10, 11]}}
{"token": ["Clinical", "trials", "that", "AVP-receptor", "antagonists", ",", "including", "C0676838#ent", "<e1>", ",", "tolvaptan", ",", "and", "C0966107#ent", "<e2>", ",", "produce", "aquaresis", ",", "the", "electrolyte-sparing", "excretion", "of", "free", "water", "to", "correct", "serum", "sodium", "concentration", "."], "h": {"id": "C0676838", "name": "C0676838#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0966107", "name": "C0966107#ent", "pos": [13, 14]}}
{"token": ["V2", "receptor", "antagonists", "such", "as", "C0676838#ent", "<e1>", ",", "tolvaptan", ",", "satavaptan", "and", "the", "V2+V1A", "receptor", "antagonist", "C0966107#ent", "<e2>", "promote", "the", "electrolyte-sparing", "excretion", "of", "free", "water", "lead", "to", "increased", "serum", "sodium"], "h": {"id": "C0676838", "name": "C0676838#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0966107", "name": "C0966107#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "although", "both", "CYP19", "and", "C1450093#ent", "<e1>", "are", "expressed", "in", "a", "high", "percentage", "of", "breast", "cancers", "C1450093#ent", "<e1>", "is", "not", "a", "major", "determinant", "of", "the", "disposition", "of", "C1367578#ent", "<e1>", "."], "h": {"id": "C1450093", "name": "C1450093#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1367578", "name": "C1367578#ent", "pos": [28, 29]}}
{"token": ["In", "conclusion", ",", "this", "study", "identifies", "several", "coexisting", "C0679247#ent", "<e1>", ",", "septicaemia", "and", "intra-abdominal", "abscess", "risk", "factors", "mortality", "following", "C0030925#ent", "<e2>"], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030925", "name": "C0030925#ent", "pos": [19, 20]}}
{"token": ["Aspirin", ",", "C0006491#ent", "<e1>", ",", "corticosteroids", ",", "and", "nutritional", "supplements", "used", "for", "chronic", "treatment", "C0030193#ent", "<e2>", "OA", "in", "cats", "."], "h": {"id": "C0006491", "name": "C0006491#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [14, 15]}}
{"token": ["HMB", "attenuated", "phosphorylation", "of", "eEF2", ",", "possibly", "by", "increasing", "phosphorylation", "of", "C1307407#ent", "<e1>", ",", "and", "also", "attenuated", "phosphorylation", "of", "C3539639#ent", "<e2>", "by", "preventing", "activation", "of", "PKR", "."], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539639", "name": "C3539639#ent", "pos": [19, 20]}}
{"token": ["75", "%", "decreases", "in", "microsomal", "and", "C3899480#ent", "<e1>", "levels", "within", "2", "h.", "The", "decreases", "in", "C0010762#ent", "<e2>", "were", "sustained", "for", "24", "h", "but", "concentrations", "returned", "to", "control", "levels", "72", "h."], "h": {"id": "C3899480", "name": "C3899480#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [15, 16]}}
{"token": ["The", "first", "was", "the", "higher", "relative", "population", "salt", "bridges", "and", "the", "presence", "of", "a", "few", "unique", "salt", "bridges", "found", "in", "C3899480#ent", "<e1>", "that", "were", "absent", "in", "all", "five", "template", "C0010762#ent", "<e2>", "."], "h": {"id": "C3899480", "name": "C3899480#ent", "pos": [20, 21]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [29, 30]}}
{"token": ["Four", "diet", "groups", "been", "used", ":", "control", "pellet", "diet", ",", "C0020473#ent", "<e1>", "(", "HL", ")", "diet", ",", "and", "C1453952#ent", "<e2>", "supplemented", "with", "two", "different", "concentrations", "of", "25-hydroxycholesterol", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [10, 11]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C1453952", "name": "C1453952#ent", "pos": [18, 19]}}
{"token": ["Four", "distinct", "familial", "types", "isolated", "C0162429#ent", "<e1>", "IGHD", ")", "are", "classified", ",", "of", "which", "type", "II", "C0271567#ent", "<e2>", "is", "the", "autosomal", "dominant", "inherited", "form", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0271567", "name": "C0271567#ent", "pos": [16, 17]}}
{"token": ["A", "14-year-old", "girl", "with", "familial", "Mediterranean", "fever", "C0031069#ent", "<e1>", ")", "had", "had", "acute", "attacks", "fever", ",", "C0000737#ent", "<e2>", "and", "arthritis", "for", "4", "years", "."], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [16, 17]}}
{"token": ["Both", "diabetic", "nephropathy", "DN", ")", "and", "nondiabetic", "nephropathy", "C1417614#ent", "<e1>", ")", "are", "reported", "to", "occur", "in", "patients", "with", "C0011860#ent", "<e2>", "DM", ")", "."], "h": {"id": "C1417614", "name": "C1417614#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [18, 19]}}
{"token": ["Analysis", "of", "banked", "human", "C3889436#ent", "<e1>", "from", "human", "immunodeficiency", "virus-infected", "patients", "also", "demonstrated", "a", "correlation", "between", "C4084754#ent", "<e2>", "concentration", "and", "C3889436#ent", "<e1>", "viral", "load"], "h": {"id": "C4084754", "name": "C4084754#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [4, 5]}}
{"token": ["This", "increase", "in", "C4084754#ent", "<e1>", "correlated", "with", "an", "increase", "in", "C3889436#ent", "<e2>", "viral", "load", "it", "may", "therefore", "represent", "a", "biomarker", "for", "the", "development", "of", "encephalitis", "."], "h": {"id": "C4084754", "name": "C4084754#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [10, 11]}}
{"token": ["In", "a", "study", "in", ">", "5000", "patients", ",", "respective", "healed", "C0014868#ent", "<e1>", "rates", "with", "once-daily", "esomeprazole", "40", "mg", "or", "C0050940#ent", "<e2>", "30", "mg", "were", "92.6", "and", "88.8", "%", "."], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0050940", "name": "C0050940#ent", "pos": [19, 20]}}
{"token": ["C0015846#ent", "<e1>", "TTS", "is", "recommended", "for", "use", "in", "C1333034#ent", "<e2>"], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333034", "name": "C1333034#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "unlike", "certain", "monotendoned", "C0015644#ent", "<e1>", "such", "as", "C2698414#ent", "<e2>", ")", ",", "the", "multitendoned", "muscles", "that", "flex", "and", "extend", "macaque", "fingers", "have", "minimal", "histochemical", "specialization"], "h": {"id": "C0015644", "name": "C0015644#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [10, 11]}}
{"token": ["Localization", "studies", "neurons", "expressing", "different", "p95-derived", "constructs", "show", "a", "codistribution", "of", "p95-APP1", "with", "C1412511#ent", "<e1>", ",", "but", "not", "C1412504#ent", "<e2>", "."], "h": {"id": "C1412511", "name": "C1412511#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412504", "name": "C1412504#ent", "pos": [18, 19]}}
{"token": ["2", ")", "Leflunomide", ",", "an", "immunosuppressive", "drug", "is", "approved", "in", "the", "European", "community", "oral", "treatment", "C0038013#ent", "<e1>", "as", "a", "slow-acting", "C3536926#ent", "<e2>"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3536926", "name": "C3536926#ent", "pos": [20, 21]}}
{"token": ["In", "the", "short-term", "studies", ",", "increases", "in", "tissue", "concentration", "of", "the", "ceramide", "synthase", "sphinganine", "(", "C1825840#ent", "<e1>", ")", "and", "the", "Sa", "to", "C1420357#ent", "<e2>", "(", "So", ")", "ratio", "were", "correlated", "with", "apoptosis", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420357", "name": "C1420357#ent", "pos": [22, 23]}}
{"token": ["C0034091#ent", "<e1>", "be", "considered", "in", "cases", "of", "pulmonary", "fibrosis", "pulmonary", "hypertension", "C0034072#ent", "<e2>", "and", "pulmonary", "edema", "congestion", "with", "normal", "left", "atrial", "pressures"], "h": {"id": "C0034091", "name": "C0034091#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "C0026848#ent", "<e1>", "is", "not", "a", "feature", "of", "C1413864#ent", "<e2>", "that", "the", "most", "prominent", "neuromuscular", "abnormality", "sensorimotor", "axonal", "polyneuropathy"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413864", "name": "C1413864#ent", "pos": [11, 12]}}
{"token": ["The", "main", "anesthetic", "drugs", "were", "pentothal", ",", "C0025688#ent", "<e1>", ",", "nitrous", "oxide", "Innovar", ",", "and", "C0030310#ent", "<e2>", "."], "h": {"id": "C0025688", "name": "C0025688#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030310", "name": "C0030310#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "DLCOsb", "and", "C1710302#ent", "<e1>", "during", "Emax", "were", "highly", "correlated", "only", "in", "C1800706#ent", "<e2>", "(", "r", ":", "-0.84", ",", "p", "less", "than", "0.01", ")", "."], "h": {"id": "C1710302", "name": "C1710302#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1800706", "name": "C1800706#ent", "pos": [13, 14]}}
{"token": ["Histologically", ",", "thymic", "atrophy", "vasculitis", ",", "C0019158#ent", "<e1>", ",", "cholangitis", ",", "myocarditis", ",", "generalized", "myositis", "and", "C0014070#ent", "<e2>", "were", "the", "main", "microscopic", "findings", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014070", "name": "C0014070#ent", "pos": [16, 17]}}
{"token": ["The", "same", "parasitic", "burden", "provoked", "only", "a", "slight", "decrease", "in", "the", "elimination", "half-life", "of", "C0360556#ent", "<e1>", "alcohol", "when", "its", "C0056387#ent", "<e2>", "administered", "."], "h": {"id": "C0360556", "name": "C0360556#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0056387", "name": "C0056387#ent", "pos": [19, 20]}}
{"token": ["The", "secondary", "objective", "to", "determine", "whether", "any", "differential", "effect", "end-organ", "complications", "exists", "between", "an", "C3536837#ent", "<e1>", "enalapril", ")", "and", "a", "C0006684#ent", "<e2>", "nisoldipine", ")", "."], "h": {"id": "C3536837", "name": "C3536837#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [20, 21]}}
{"token": ["C3536837#ent", "<e1>", "ACEI", ")", "and", "C0006684#ent", "<e2>", "CCB", ")", "have", "recently", "emerged", "as", "antihypertensive", "drugs", "with", "renoprotective", "action", "directed", "specifically", "to", "the", "kidney", "."], "h": {"id": "C3536837", "name": "C3536837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [5, 6]}}
{"token": ["The", "most", "common", "combination", "was", "\u00df-blockers", "and", "diuretics", ",", "then", "C3536837#ent", "<e1>", "diuretics", ",", "finally", "\u00df-blockers", "and", "C0006684#ent", "<e2>"], "h": {"id": "C3536837", "name": "C3536837#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [17, 18]}}
{"token": ["Only", "two", "of", "16", "neonates", "with", "serious", "C0004623#ent", "<e1>", "eight", "of", "19", "postneonates", "with", "features", "of", "C0036690#ent", "<e2>", "or", "meningitis", "received", "parenteral", "antibiotics"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [16, 17]}}
{"token": ["These", "results", "link", "C0971285#ent", "<e1>", "to", "C3541301#ent", "<e2>", "function", ",", "with", "C0971285#ent", "<e1>", "MCAK", "'s", "activity", "and", "its", "localization", "at", "the", "centromere", "and", "kinetochore", "."], "h": {"id": "C3541301", "name": "C3541301#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0971285", "name": "C0971285#ent", "pos": [3, 4]}}
{"token": ["Furthermore", "we", "used", "polymerase", "chain", "reaction", "PCR", ")", "followed", "by", "the", "analysis", "of", "restriction", "fragments", "polymorphism", "(", "RFLP", ")", "technique", "to", "identify", "the", "known", "mutant", "C0002085#ent", "<e1>", "of", "the", "C0796518#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0796518", "name": "C0796518#ent", "pos": [29, 30]}}
{"token": ["The", "increased", "clearance", "of", "sulphamethoxazole", "in", "cystic", "fibrosis", "patients", "appears", "unlikely", "to", "be", "due", "to", "erythrocyte", "arylamine", "N-acetyltransferase", "type", "1", "or", "to", "inheritance", "of", "C0002085#ent", "<e1>", "at", "either", "the", "NAT1", "or", "C0796518#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0796518", "name": "C0796518#ent", "pos": [31, 32]}}
{"token": ["cDNA", "clones", "spanning", "both", "C1705084#ent", "<e1>", "and", "the", "downstream", "C1537994#ent", "<e2>", "ND5", ")", "gene", "were", "isolated", ",", "indicating", "that", "mature", "C1705084#ent", "<e1>", "and", "ND5", "transcripts", "from", "a", "common", "precursor", "."], "h": {"id": "C1537994", "name": "C1537994#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705084", "name": "C1705084#ent", "pos": [4, 5]}}
{"token": ["The", "central", "regions", "of", "the", "intracellular", "loops", "of", "C1538918#ent", "<e1>", "were", "all", "highly", "accessible", "to", "C0963867#ent", "<e2>", "."], "h": {"id": "C1538918", "name": "C1538918#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0963867", "name": "C0963867#ent", "pos": [15, 16]}}
{"token": ["Pharmacological", "or", "genetic", "ablation", "adrenergic", "neurotransmission", "indicates", "that", "C3887648#ent", "<e1>", "(", "NE", ")", "signaling", "controls", "G-CSF-induced", "osteoblast", "suppression", "bone", "C1332817#ent", "<e2>", "downregulation", ",", "and", "HSPC", "mobilization", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332817", "name": "C1332817#ent", "pos": [19, 20]}}
{"token": ["This", "screening", "also", "yielded", "four", "additional", "cDNA", "sequences", "C0017337#ent", "<e1>", "were", "not", "present", "on", "this", "gene", "cluster", "belonged", "to", "specific", "C1332739#ent", "<e2>", "gene", "families", "on", "this", "contig", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332739", "name": "C1332739#ent", "pos": [20, 21]}}
{"token": ["We", "also", "observed", "decreased", "gene-specific", "DNA", "methylation", "of", "the", "C0017337#ent", "<e1>", "(", "Cdkn3", ")", "that", "encodes", "for", "C1332739#ent", "<e2>", ",", "correlating", "with", "increased", "expression", "of", "this", "protein", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332739", "name": "C1332739#ent", "pos": [17, 18]}}
{"token": ["Conversion", "to", "chronic-phase", "C0023521#ent", "<e1>", ",", "a", "rare", "occurrence", "in", "C1704799#ent", "<e2>", "may", "have", "contributed", "to", "the", "unusually", "long", "survival"], "h": {"id": "C0023521", "name": "C0023521#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704799", "name": "C1704799#ent", "pos": [10, 11]}}
{"token": ["C0172956#ent", "<e1>", "(", "matrix", "metalloproteinase-8", "MMP-8", ")", "is", "an", "C0623362#ent", "<e2>", "mainly", "produced", "by", "neutrophils", "and", "associated", "with", "inflammatory", "conditions"], "h": {"id": "C0172956", "name": "C0172956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [9, 10]}}
{"token": ["The", "mammalian", "C0172956#ent", "<e1>", "are", "a", "subgroup", "of", "the", "matrix", "metalloproteinases", "C0623362#ent", "<e2>", ")", "that", "are", "uniquely", "able", "to", "cleave", "triple", "helical", "fibrillar", "collagens"], "h": {"id": "C0172956", "name": "C0172956#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [11, 12]}}
{"token": ["Thirty", "renal", "transplant", "recipients", "were", "studied", "prospectively", "to", "evaluate", "the", "relationship", "of", "C2984034#ent", "<e1>", "cytotoxic", "lymphocyte", "responses", "to", "clinical", "outcome", "C0010823#ent", "<e2>"], "h": {"id": "C2984034", "name": "C2984034#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [20, 21]}}
{"token": ["C0772200#ent", "<e1>", "is", "a", "unique", "C0003299#ent", "<e2>", "a", "novel", "mechanism", "of", "action", "."], "h": {"id": "C0772200", "name": "C0772200#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [5, 6]}}
{"token": ["All", "these", "alterations", "resulted", "in", "an", "abnormal", "mRNA", ",", "which", "comprises", "the", "leader", ",", "a", "84-bp", "alien", "exon", "from", "C0028326#ent", "<e1>", "and", "the", "C1422394#ent", "<e2>", "and", "CH3", "exons", "of", "the", "alpha", "1-gene", "."], "h": {"id": "C0028326", "name": "C0028326#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1422394", "name": "C1422394#ent", "pos": [23, 24]}}
{"token": ["The", "results", "showed", "that", "compared", "with", "single", "Cd2+", "treatment", ",", "C0007804#ent", "<e1>", "addition", "lessened", "the", "reactive", "oxygen", "species", "C3896642#ent", "<e2>", "H2O2", ")", "generation", "rates", "endogenous", "C0007804#ent", "<e1>", "content", ",", "and", "antioxidant", "enzyme", "activities", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3896642", "name": "C3896642#ent", "pos": [18, 19]}}
{"token": ["The", "suppressible", "codons", "in", "the", "trpA", "messenger", "RNA", "the", "lysine", "codons", "C1364818#ent", "<e1>", "and", "AAG", ",", "and", "the", "glutamic", "acid", "codons", "C1414899#ent", "<e2>", "and", "GAG", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414899", "name": "C1414899#ent", "pos": [21, 22]}}
{"token": ["We", "demonstrated", "selective", "activation", "of", "caspases", "in", "the", "thymus", "during", "heat", "shock", "i.e.", "primary", "activation", "C1720986#ent", "<e1>", "but", "not", "C0010656#ent", "<e2>", "8)", "and", "effector", "caspase", "3", "but", "not", "caspase", "6", ")", "."], "h": {"id": "C1720986", "name": "C1720986#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "found", "that", "dexamethasone", "(", "C0011816#ent", "<e1>", ")", ",", "a", "potent", "synthetic", "C1367452#ent", "<e2>", ",", "partly", "antagonizes", "the", "cAMP-dependent", "stimulation", "of", "the", "mouse", "Star", "promoter", "MA-10", "Leydig", "cells", "revealed", "by", "transient", "transfection", "assays"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [14, 15]}}
{"token": ["There", "is", "experimental", "evidence", "to", "suggest", "that", "C0020445#ent", "<e1>", "may", "play", "a", "pathogenetic", "role", "in", "progressive", "C0268731#ent", "<e2>"], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "C0020445#ent", "<e1>", "be", "responsible", "for", "C0268731#ent", "<e2>", "in", "nephrotic", "syndrome"], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [9, 10]}}
{"token": ["The", "role", "of", "lipid", "abnormalities", "C0020445#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0268731#ent", "<e2>", "been", "demonstrated", "in", "animal", "models", "and", "a", "link", "between", "C0020445#ent", "<e1>", "and", "diabetic", "nephropathy", "been", "established", "in", "humans", "."], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [11, 12]}}
{"token": ["Mutations", "in", "the", "voltage-gated", "sodium", "channel", "subunit", "gene", "C1419856#ent", "<e1>", "have", "been", "associated", "with", "febrile", "seizures", "FSs", ")", "in", "C2936739#ent", "<e2>", "generalized", "epilepsy", "febrile", "seizures", "plus", "GEFS+", ")", "families", "and", "severe", "myoclonic", "epilepsy", "infancy", "."], "h": {"id": "C1419856", "name": "C1419856#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "the", "C1419856#ent", "<e1>", "SCN1A", "have", "been", "associated", "with", "febrile", "seizures", "FSs", ")", "in", "C2936739#ent", "<e2>", "generalized", "epilepsy", "febrile", "seizures", "plus", "GEFS+", ")", "families", "and", "severe", "myoclonic", "epilepsy", "infancy", "."], "h": {"id": "C1419856", "name": "C1419856#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [15, 16]}}
{"token": ["Using", "large", "plots", "and", "commercial", "application", "methodologies", ",", "liquid", "bait", "deployed", "in", "June", "resulted", "in", "lower", "C1705600#ent", "<e1>", "density", "and", "fruit", "C0851341#ent", "<e2>", ",", "but", "it", "had", "no", "effect", "mealybug", "density", "."], "h": {"id": "C1705600", "name": "C1705600#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0851341", "name": "C0851341#ent", "pos": [21, 22]}}
{"token": ["Similar", "treatments", "in", "a", "soft", "scale-infested", "vineyard", "showed", "only", "a", "reduction", "of", "C1705600#ent", "<e1>", "density", "and", "fruit", "C0851341#ent", "<e2>", "in", "only", "the", "boric", "acid", "thiamethoxam", "treatments", "."], "h": {"id": "C1705600", "name": "C1705600#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0851341", "name": "C0851341#ent", "pos": [17, 18]}}
{"token": ["C1839259#ent", "<e1>", "determinations", "were", "made", "by", "separating", "free", "C0063647#ent", "<e2>", "and", "its", "complex", "with", "the", "antibody", "in", "equilibrated", "solutions", "in", "6", "s", "or", "less", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0063647", "name": "C0063647#ent", "pos": [8, 9]}}
{"token": ["The", "inhibitory", "effect", "of", "histamine", "was", "antagonized", "by", "impromidine", "and", "C0006408#ent", "<e1>", ",", "but", "was", "not", "affected", "by", "C0887016#ent", "<e2>", ",", "ranitidine", ",", "metitepine", "and", "phentolamine", "."], "h": {"id": "C0006408", "name": "C0006408#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0887016", "name": "C0887016#ent", "pos": [18, 19]}}
{"token": ["The", "C3889383#ent", "<e1>", "isoform", "readily", "phosphorylates", "C0030956#ent", "<e2>", "corresponding", "to", "the", "reported", "AMPK", "phosphorylation", "sites", "in", "rat", ",", "chicken", ",", "and", "yeast", "acetyl-CoA", "carboxylase", "rat", "hydroxymethylglutaryl-CoA", "reductase", "not", "phosphorylase", "kinase"], "h": {"id": "C3889383", "name": "C3889383#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}}
{"token": ["The", "efficiency", "to", "promote", "the", "dephosphorylation", "of", "both", "proteins", "matches", "their", "capacity", "to", "inhibit", "purified", "C1413290#ent", "<e1>", "suggesting", "that", "C1172090#ent", "<e2>", "is", "the", "major", "kinase", "phosphorylating", "hSpt5", "and", "Rpb1", "in", "vivo"], "h": {"id": "C1413290", "name": "C1413290#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1172090", "name": "C1172090#ent", "pos": [19, 20]}}
{"token": ["Tat", "function", "mediated", "by", "a", "cellular", "protein", "kinase", "as", "C1413290#ent", "<e1>", "(", "cyclin", "T1/P-TEFb", ")", "that", "is", "composed", "of", "C1172090#ent", "<e2>", "and", "cyclin", "T1"], "h": {"id": "C1413290", "name": "C1413290#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1172090", "name": "C1172090#ent", "pos": [19, 20]}}
{"token": ["We", "considered", "the", "following", "drugs", ":", "amphetamine", ",", "amlodipine", ",", "chlorprothixene", ",", "fentanyl", ",", "haloperidol", ",", "ketobemidone", ",", "methadone", ",", "mirtazapine", ",", "C0171023#ent", "<e1>", ",", "quetiapine", ",", "sertraline", "and", "C0078847#ent", "<e2>", "."], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0078847", "name": "C0078847#ent", "pos": [29, 30]}}
{"token": ["Mutations", "in", "A-type", "lamins", "cause", "a", "bewildering", "range", "of", "tissue-specific", "diseases", "termed", "'", "laminopathies", "'", ",", "including", "C0410189#ent", "<e1>", "the", "devastating", "C0033300#ent", "<e2>", "which", "mimics", "premature", "aging"], "h": {"id": "C0410189", "name": "C0410189#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0033300", "name": "C0033300#ent", "pos": [21, 22]}}
{"token": ["Adverse", "events", "C0061851#ent", "<e1>", "were", "frequent", "but", "mild", ",", "with", "constipation", "and", "C0018681#ent", "<e2>", "being", "most", "common", "."], "h": {"id": "C0061851", "name": "C0061851#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [12, 13]}}
{"token": ["Transcutaneous", "liver", "biopsies", "collected", "for", "measurement", "of", "protein", "tyrosine", ",", "cationic", "amino", "acid", "transporter", "C1711111#ent", "<e1>", "and", "constitutive", "NO", "synthase", "C0669365#ent", "<e2>", ")", ",", "inducible", "NOS", "iNOS", ")", ",", "and", "arginase", "activity"], "h": {"id": "C1711111", "name": "C1711111#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [20, 21]}}
{"token": ["Abnormal", "mGluR", "signaling", "could", "be", "responsible", "for", "remarkably", "diverse", "psychiatric", "and", "neurological", "symptoms", "C0016667#ent", "<e1>", "including", "delayed", "cognitive", "development", "C0036572#ent", "<e2>", ",", "anxiety", ",", "movement", "disorders", "obesity", "."], "h": {"id": "C0016667", "name": "C0016667#ent", "pos": [13, 14]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [19, 20]}}
{"token": ["The", "ATP-dependent", "tubulin-tyrosine", "ligase", "C1427631#ent", "<e1>", ")", "restores", "the", "carboxy-terminal", "tyrosine", "of", "alpha", "tubulin", "in", "C3539817#ent", "<e2>", "has", "been", "previously", "detyrosinated", "."], "h": {"id": "C1427631", "name": "C1427631#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539817", "name": "C3539817#ent", "pos": [15, 16]}}
{"token": ["C0054836#ent", "<e1>", "confirmed", "a", "significant", "effect", "on", "myocardial", "ischemia", "C0020538#ent", "<e2>"], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "compare", "nifedipine", "and", "C0054836#ent", "<e1>", "in", "the", "treatment", "of", "de", "novo", "C0020538#ent", "<e2>", "orthotopic", "liver", "transplantation", "OLT", ")", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["Serum", "concentrations", "of", "C0033148#ent", "<e1>", "and", "its", "metabolites-phenobarbitone", "and", "phenylethylmalonamide-were", "measured", "in", "40", "C0014544#ent", "<e2>", "patients", "receiving", "treatment", "with", "C0033148#ent", "<e1>", "alone", "or", "C0033148#ent", "<e1>", "plus", "phenytoin", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0033148", "name": "C0033148#ent", "pos": [3, 4]}}
{"token": ["The", "C0014544#ent", "<e1>", "not", "respond", "to", "C0033148#ent", "<e2>", "monotherapy", ",", "but", "addition", "of", "ubiquinone-10", "and", "radical", "scavengers", "reduced", "seizure", "frequency"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0033148", "name": "C0033148#ent", "pos": [6, 7]}}
{"token": ["C3273878#ent", "<e1>", "processing", "proceeded", "normally", "in", "murine", "cell", "lines", "C1420354#ent", "<e2>", "or", "PARL", "."], "h": {"id": "C3273878", "name": "C3273878#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420354", "name": "C1420354#ent", "pos": [9, 10]}}
{"token": ["C0017168#ent", "<e1>", "presently", "accepted", "as", "being", "part", "of", "the", "C0032763#ent", "<e2>", "complex", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032763", "name": "C0032763#ent", "pos": [9, 10]}}
{"token": ["C0017168#ent", "<e1>", "occur", "in", "association", "with", "other", "C0032763#ent", "<e2>"], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032763", "name": "C0032763#ent", "pos": [7, 8]}}
{"token": ["In", "MDA-MB-231-VP7", "cells", ",", "hyperphosphorylation", "coincided", "with", "increased", "C0108555#ent", "<e1>", "mRNA", "and", "protein", "levels", "suggesting", "a", "role", "for", "this", "C0211705#ent", "<e2>", "in", "the", "acquired", "hyperphosphorylation", "."], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [19, 20]}}
{"token": ["Together", ",", "the", "evidence", "suggests", "that", "C0108555#ent", "<e1>", "is", "likely", "a", "C0211705#ent", "<e2>", "responsible", "for", "the", "Ser(363", ")", "phosphorylation", ",", "leading", "to", "the", "destablization", "and", "degradation", "of", "Cx45.6", "."], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "implied", "that", "spinal", "cord", "motoneurons", "could", "be", "a", "potential", "extranigral", "target", "of", "neurodegeneration", "during", "pathogenesis", "of", "C3160718#ent", "<e1>", "in", "the", "CNS", "and", "that", "C0006784#ent", "<e2>", "inhibition", "could", "provide", "neuroprotection", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [25, 26]}}
{"token": ["An", "insulin-dependent", "diabetes", "mellitus", "gene", "(", "IDDM13", ")", "has", "recently", "been", "mapped", "to", "a", "region", "of", "distal", "chromosome", "2q", "which", "is", "C1419895#ent", "<e1>", "to", "the", "region", "of", "mouse", "chromosome", "1", "a", "murine", "susceptibility", "gene", "C0011854#ent", "<e2>", ",", "Idd5", "."], "h": {"id": "C1419895", "name": "C1419895#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [34, 35]}}
{"token": ["OHAs", "that", "stimulate", "insulin", "secretion", "or", "temporally", "might", "be", "useful", "C0013227#ent", "<e1>", "for", "controlling", "elderly", "diabetic", "patients", "characterized", "by", "post-prandial", "C0020456#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [20, 21]}}
{"token": ["Adverse", "reactions", "the", "C0013227#ent", "<e1>", "included", "diarrhea", "in", "one", "patient", "and", "transient", "C0020456#ent", "<e2>", "in", "another", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [12, 13]}}
{"token": ["The", "C0013227#ent", "<e1>", "elicits", "a", "triphasic", "response", "the", "blood", "glucose", "level", "comprising", "an", "initial", "C0020456#ent", "<e2>", "followed", "by", "a", "transient", "fall", ",", "and", "restitution", "of", "normal", "values", "...", "4", "days", "after", "the", "treatment", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [14, 15]}}
{"token": ["ER81", "may", "mediate", "C0087071#ent", "<e1>", "telomerase-negative", "fibroblasts", "stimulated", "by", "oncogenes", "Her2/Neu", "C0034678#ent", "<e2>", ",", "and", "Raf", "."], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [11, 12]}}
{"token": ["In", "a", "T-cell", "lymphoblastic", "lymphoma", "cell", "line", "HT-1", ",", "the", "C1424284#ent", "<e1>", "fused", "to", "SUSP1", "(", "SUMO-1-specific", "protease", ",", "creating", "a", "C1857982#ent", "<e2>"], "h": {"id": "C1424284", "name": "C1424284#ent", "pos": [10, 11]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1857982", "name": "C1857982#ent", "pos": [21, 22]}}
{"token": ["sEH", "inhibitors", "have", "C0003364#ent", "<e1>", "and", "antiinflammatory", "actions", "have", "been", "demonstrated", "to", "decrease", "C0917798#ent", "<e2>", "renal", "injury", "rat", "models", "of", "hypertension", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "the", "combination", "of", "increased", "fluid", "intake", "and", "the", "avoidance", "of", "C0003364#ent", "<e1>", "helps", "prevent", "C0917798#ent", "<e2>", "subarachnoid", "hemorrhage"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [17, 18]}}
{"token": ["We", "investigated", "in", "a", "consecutive", "series", "of", "134", "patients", "with", "aneurysmal", "subarachnoid", "hemorrhage", "whether", "institution", "of", "C0003364#ent", "<e1>", "related", "to", "the", "incidence", "of", "C0917798#ent", "<e2>", "rebleeding", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [23, 24]}}
{"token": ["Thirty-two", "diabetic", "patients", "with", "C0700345#ent", "<e1>", "treated", "orally", "with", "400", "mg", "C0022625#ent", "<e2>", "once", "daily", "for", "five", "days", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [11, 12]}}
{"token": ["C0128665#ent", "<e1>", "is", "a", "competitive", "inhibitor", "of", "3-hydroxy-3-methylglutaryl", "coenzyme", "A", "C0020374#ent", "<e2>", "the", "key", "regulatory", "enzyme", "the", "sequence", "that", "catalyzes", "the", "conversion", "of", "acetate", "to", "mevalonic", "acid", "cholesterol", "biosynthesis"], "h": {"id": "C0128665", "name": "C0128665#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "steroid", "production", "was", "unimpaired", "upon", "the", "addition", "of", "C0128665#ent", "<e1>", ",", "a", "potent", "inhibitor", "of", "C0020374#ent", "<e2>"], "h": {"id": "C0128665", "name": "C0128665#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [17, 18]}}
{"token": ["The", "present", "article", "describes", "the", "clinical", "and", "pathological", "findings", "in", "5", "C3854222#ent", "<e1>", "patients", "with", "C0040558#ent", "<e2>"], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040558", "name": "C0040558#ent", "pos": [15, 16]}}
{"token": ["The", "targeted", "degradation", "of", "C1706038#ent", "<e1>", "following", "its", "phosphorylation", "by", "C0108855#ent", "<e2>", "identifies", "a", "new", "mechanism", "through", "which", "C1706038#ent", "<e1>", "activity", "can", "be", "regulated", "in", "coordination", "with", "the", "cell", "cycle", "machinery"], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706038", "name": "C1706038#ent", "pos": [4, 5]}}
{"token": ["In", "electrically", "driven", "atria", ",", "the", "negative", "inotropic", "effect", "C0131796#ent", "<e1>", "was", "less", "marked", "than", "that", "of", "imipramine", "and", "C0011685#ent", "<e2>", "but", "similar", "to", "that", "of", "lofepramine", "."], "h": {"id": "C0131796", "name": "C0131796#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [19, 20]}}
{"token": ["It", "is", "concluded", "that", "C0131796#ent", "<e1>", "exerted", "fewer", "cardiodepressant", "effects", "than", "imipramine", "and", "C0011685#ent", "<e2>", "in", "isolated", "guinea-pig", "atrial", "ventricular", "muscle", "fibres", "."], "h": {"id": "C0131796", "name": "C0131796#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "in", "marked", "contrast", "to", "C0001883#ent", "<e1>", "induced", "by", "histamine", "or", "methacholine", ",", "C0004099#ent", "<e2>", "associated", "with", "glottic", "widening", ",", "which", "occurs", "concomitantly", "with", "a", "decrease", "in", "lower", "airway", "caliber"], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [15, 16]}}
{"token": ["Mutations", "in", "the", "nuclear", "gene", "C1333327#ent", "<e1>", "TP", ")", "cause", "mitochondrial", "neurogastrointestinal", "encephalomyopathy", "MNGIE", ")", ",", "an", "C3899988#ent", "<e2>", "mitochondrial", "dysfunction", "mitochondrial", "DNA", "abnormalities"], "h": {"id": "C1333327", "name": "C1333327#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [17, 18]}}
{"token": ["Neither", "21-hydroxylase", "activity", "the", "reduced", "CO", "difference", "spectrum", ",", "nor", "the", "C1366515#ent", "<e1>", "spectrum", "of", "digested", "C1413861#ent", "<e2>", "differed", "from", "those", "of", "undigested", "C1413861#ent", "<e2>", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413861", "name": "C1413861#ent", "pos": [16, 17]}}
{"token": ["Also", "discussed", "are", "more", "recent", "findings", "on", "nitric", "oxide", "donors", "such", "as", "molsidomine", ",", "PETN", "and", "the", "combination", "treatment", "C0022251#ent", "<e1>", "dinitrate", "and", "hydralazine", "of", "patients", "with", "coronary", "artery", "disease", "C0018802#ent", "<e2>"], "h": {"id": "C0022251", "name": "C0022251#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [30, 31]}}
{"token": ["The", "effect", "of", "long-term", "vasodilator", "therapy", "hydralazine", ",", "ecarazine", "or", "budralazine", "+", "C0022251#ent", "<e1>", "dinitrate", ")", "were", "evaluated", "for", "20", "patients", "with", "C0018802#ent", "<e2>", "to", "dilated", "cardiomyopathy", "DCM", ")", "resistant", "to", "conventional", "therapy"], "h": {"id": "C0022251", "name": "C0022251#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [22, 23]}}
{"token": ["Similarly", ",", "lipopolysaccharides", "(", "C2697656#ent", "<e1>", ")", "extracted", "from", "A.", "actinomycetemcomitans", "F.", "nucleatum", ",", "and", "E.", "coli", "induced", "C1705979#ent", "<e2>", "expression", "in", "7.7/huTLR4", "cells", ",", "but", "C2697656#ent", "<e1>", "from", "P.", "gingivalis", "C.", "ochracea", "did", "not", "."], "h": {"id": "C1705979", "name": "C1705979#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [4, 5]}}
{"token": ["In", "vitro", "the", "proliferation", "and", "up-regulation", "of", "surface", "activation", "markers", "such", "as", "CD86", "and", "C1705979#ent", "<e1>", "induced", "by", "C2697656#ent", "<e2>", "and", "an", "antibody", "against", "RP105", "were", "decreased", "."], "h": {"id": "C1705979", "name": "C1705979#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [18, 19]}}
{"token": ["The", "genes", "encoding", "C1336579#ent", "<e1>", ",", "DnaJ", "and", "C1426341#ent", "<e2>", "of", "V.", "harveyi", "were", "cloned", "into", "expression", "vectors", "grpE", "was", "sequenced", "."], "h": {"id": "C1336579", "name": "C1336579#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1426341", "name": "C1426341#ent", "pos": [8, 9]}}
{"token": ["The", "DnaK", "chaperone", "system", ",", "consisting", "of", "C1336579#ent", "<e1>", ",", "DnaJ", ",", "and", "C1426341#ent", "<e2>", ",", "remodels", "and", "refolds", "proteins", "during", "both", "normal", "growth", "stress", "conditions", "."], "h": {"id": "C1336579", "name": "C1336579#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1426341", "name": "C1426341#ent", "pos": [13, 14]}}
{"token": ["C0041234#ent", "<e1>", "the", "main", "cause", "of", "C0006384#ent", "<e2>", "AV", "block", "endemic", "areas", "."], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006384", "name": "C0006384#ent", "pos": [6, 7]}}
{"token": ["Neither", "did", "the", "C-fibre", "C0002763#ent", "<e1>", "capsaicin", "10(-8)-10(-4", ")", "M", "increase", "C1428360#ent", "<e2>", "in", "explants", "from", "human", "adenoids", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [11, 12]}}
{"token": ["Nitrous", "oxide", "a", "C0002763#ent", "<e1>", "effect", "on", "cerebral", "metabolism", "is", "associated", "with", "increase", "in", "C1428360#ent", "<e2>", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [14, 15]}}
{"token": ["Inhibitors", "of", "NOS", ",", "sGC", ",", "and", "PKG", "can", "block", "the", "C0002763#ent", "<e1>", "effect", "of", "L-Arg", "on", "C1428360#ent", "<e2>", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "have", "studied", "the", "effect", "of", "C0771004#ent", "<e1>", "nasal", "spray", "the", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C0771004", "name": "C0771004#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [14, 15]}}
{"token": ["Calpain", "I", "a", "C0006784#ent", "<e1>", "has", "been", "recently", "shown", "to", "degrade", "C1418888#ent", "<e2>", "in", "vitro"], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [11, 12]}}
{"token": ["C0006784#ent", "<e1>", "a", "calcium-dependent", "cysteine", "proteinase", "has", "been", "recently", "shown", "to", "degrade", "C1418888#ent", "<e2>", "in", "vitro"], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [12, 13]}}
{"token": ["This", "activation", "is", "efficient", "in", "the", "presence", "of", "cells", ",", "and", "C0006784#ent", "<e1>", "binds", "to", "the", "cell", "surface", "C1418888#ent", "<e2>", "and", "activates", "latent", "TGF-beta", ",", "which", "is", "targeted", "to", "the", "same", "surface", "."], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [18, 19]}}
{"token": ["Comparison", "between", "two", "semiquantitative", "methods", "a", "quantitative", "evaluation", "of", "myocardial", "blood", "flow", "MBF", ")", "for", "assessment", "of", "myocardial", "perfusion", "reserve", "C4284033#ent", "<e1>", ")", "in", "patients", "with", "C0010068#ent", "<e2>", "."], "h": {"id": "C4284033", "name": "C4284033#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [26, 27]}}
{"token": ["The", "first", "factor", "to", "interact", "with", "C0035679#ent", "<e1>", "transcripts", "is", "C1337080#ent", "<e2>", "which", "binds", "principally", "via", "its", "conserved", "N-terminal", "domain", "(", "NTD", ")", ",", "to", "the", "UUU-OH", "motif", "that", "results", "from", "transcription", "termination"], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1337080", "name": "C1337080#ent", "pos": [10, 11]}}
{"token": ["The", "data", "demonstrate", "that", "regulation", "of", "Pol", "I", "gene", "transcription", "involve", "an", "antirepression", "mechanism", "as", "already", "documented", "for", "C0035679#ent", "<e1>", "suggest", "that", "C1337080#ent", "<e2>", "be", "causally", "involved", "in", "repressor-mediated", "down", "regulation", "of", "rRNA", "synthesis", "."], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1337080", "name": "C1337080#ent", "pos": [22, 23]}}
{"token": ["Finally", ",", "the", "C0005220#ent", "<e1>", "mRNA", "levels", "were", "found", "to", "be", "similar", "in", "each", "C1417746#ent", "<e2>", "series", ",", "suggesting", "a", "translational", "effect", "gene", "expression"], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417746", "name": "C1417746#ent", "pos": [14, 15]}}
{"token": ["A", "model", "is", "presented", "for", "the", "inhibition", "of", "apoptosis", "during", "thermotolerance", "in", "which", "C1333928#ent", "<e1>", "preferentially", "blocks", "C3899480#ent", "<e2>", ",", "whereas", "Hsp72", "interferes", "with", "apoptosomal", "caspase", "activation"], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3899480", "name": "C3899480#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "NAMI-A", "was", "able", "to", "down-regulate", "C1333928#ent", "<e1>", "expression", "and", "provoke", "the", "release", "of", "C3899480#ent", "<e2>", "the", "cytosol", "."], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3899480", "name": "C3899480#ent", "pos": [15, 16]}}
{"token": ["In", "well-designed", "trials", ",", "a", "single", "4", "mg", "dose", "of", "C0257685#ent", "<e1>", "good", "efficacy", "in", "the", "treatment", "of", "patients", "with", "C0020437#ent", "<e2>", "of", "malignancy", "."], "h": {"id": "C0257685", "name": "C0257685#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [20, 21]}}
{"token": ["NSAIDs", "block", "cyclooxygenase", "activities", "of", "the", "closely", "related", "C1565830#ent", "<e1>", "synthase-1", "and", "C1565830#ent", "<e1>", "synthase-2", "(", "C1335271#ent", "<e1>", "and", "PGHS-2", ")", "isozymes", "."], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335271", "name": "C1335271#ent", "pos": [16, 17]}}
{"token": ["The", "large", "stimulation", "of", "C1565830#ent", "<e1>", "become", "an", "important", "criterion", "for", "evaluation", "of", "putative", "C1335271#ent", "<e2>", "reaction", "mechanisms", "."], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335271", "name": "C1335271#ent", "pos": [14, 15]}}
{"token": ["The", "antiserum", "was", "monospecific", ",", "reacted", "with", "C1565830#ent", "<e1>", "on", "Western", "blots", "a", "limiting", "dilution", "of", "1:500,000", "and", "immunoprecipitated", "C1565830#ent", "<e1>", "synthesized", "by", "in", "vitro", "translation", "of", "C1335271#ent", "<e1>", "messenger", "RNA"], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335271", "name": "C1335271#ent", "pos": [27, 28]}}
{"token": ["We", "present", "a", "patient", "who", "had", "ingested", "C0074722#ent", "<e1>", "treatment", "of", "C0013395#ent", "<e2>", "forty", "years", "at", "increasing", "doses", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [11, 12]}}
{"token": ["Incubation", "of", "C0019348#ent", "<e1>", "human", "fibroblasts", "with", "the", "serum", "from", "a", "patient", "with", "C0019345#ent", "<e2>", "the", "cells", "susceptible", "to", "immune", "lysis", "human", "mononuclear", "leukocytes", "MNL", ")", "as", "well", "as", "complement", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0019345", "name": "C0019345#ent", "pos": [13, 14]}}
{"token": ["A", "comparison", "was", "made", "of", "the", "ethnic", ",", "social", "and", "environmental", "histories", "staff", "members", "to", "C0019348#ent", "<e1>", "infections", "and", "of", "seronegative", "staff", "members", "no", "record", "of", "C0019345#ent", "<e2>"], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0019345", "name": "C0019345#ent", "pos": [26, 27]}}
{"token": ["In", "contrast", ",", "TPA", "+", "IFN-gamma", "costimulation", "neither", "increased", "the", "expression", "of", "C1416958#ent", "<e1>", "or", "other", "mad/mnt", "family", "genes", "altered", "heterodimerization", "or", "C0812382#ent", "<e2>", "C1416958#ent", "<e1>", "."], "h": {"id": "C1416958", "name": "C1416958#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [22, 23]}}
{"token": ["Roxithromycin", "has", "proven", "clinical", "efficacy", "upper", "and", "lower", "C0035243#ent", "<e1>", "skin", "and", "soft", "tissue", "infections", "C2314882#ent", "<e2>", "orodental", "infections", "and", "appears", "to", "be", "as", "effective", "as", "more", "established", "treatments", "including", "erythromycin", ",", "amoxicillin/clavulanic", "acid", "cefaclor", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [15, 16]}}
{"token": ["Ureaplasmas", "are", "likely", "to", "be", "complicating", "agents", "several", "diseases", ",", "including", "C0035243#ent", "<e1>", "conjunctivitis", "and", "C2314882#ent", "<e2>", "alone", "they", "can", "induce", "mild", "disease", "the", "lung", "and", "conjunctiva", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [15, 16]}}
{"token": ["In", "this", "regard", ",", "C0911469#ent", "<e1>", "seems", "to", "be", "the", "C1308278#ent", "<e2>", "counterpart", "for", "regulating", "the", "inflammatory", "branch", "the", "caspase", "cascade"], "h": {"id": "C0911469", "name": "C0911469#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1308278", "name": "C1308278#ent", "pos": [10, 11]}}
{"token": ["Severe", "C0025007#ent", "<e1>", "cases", "(", "those", "who", "developed", "diarrhoea", ",", "pneumonia", ",", "C0029882#ent", "<e2>", "encephalitis", "or", "haemorrhagic", "rash", "had", "similar", "vaccination", "rates", "time", "intervals", "vaccination", "as", "uncomplicated", "C0025007#ent", "<e1>", "cases", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [12, 13]}}
{"token": ["C0025007#ent", "<e1>", "often", "accompanies", "diverse", "complications", ",", "including", "pneumonitis", ",", "C0029882#ent", "<e2>", "and", "central", "nervous", "system", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [10, 11]}}
{"token": ["Therapy", "with", "an", "C3536835#ent", "<e1>", "and", "a", "beta-lactam", "remains", "common", "empirical", "therapy", "C0015967#ent", "<e2>", "neutropenic", "patients", "."], "h": {"id": "C3536835", "name": "C3536835#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [12, 13]}}
{"token": ["Pediatric", "C3536835#ent", "<e1>", "usage", "includes", "therapy", "of", "neonatal", "infections", "cystic", "fibrosis", "C0015967#ent", "<e2>", "neutropenic", "episodes", "in", "patients", "with", "cancer", ",", "abdominal", "surgery", "bacterial", "endocarditis", "and", "gram-negative", "central", "nervous", "system", "infections"], "h": {"id": "C3536835", "name": "C3536835#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [11, 12]}}
{"token": ["In", "the", "elderly", "hypertensive", "patient", ",", "an", "arteriolar", "and", "venous", "vasodilator", "such", "as", "an", "C0242889#ent", "<e1>", "slow", "channel", "calcium", "blocker", "or", "a", "converting", "C0919438#ent", "<e2>", "will", "lower", "total", "peripheral", "resistance", "unburden", "the", "left", "ventricle"], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0919438", "name": "C0919438#ent", "pos": [23, 24]}}
{"token": ["Our", "results", "indicate", "that", "polymorphisms", "in", "the", "TLR4", "receptor", "C1826449#ent", "<e1>", "and", "C0812246#ent", "<e2>", "promoter", "region", "not", "strongly", "associated", "with", "in", "vivo", "ex", "vivo", "C0812246#ent", "<e2>", "production", "capacity", "upon", "endotoxin", "stimulation", "."], "h": {"id": "C1826449", "name": "C1826449#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [12, 13]}}
{"token": ["Ca(2", "+", ")", "channel", "blockers", "such", "as", "1,4-dihydropyridines", ",", "phenylalkylamines", ",", "C0282138#ent", "<e1>", "and", "mibefradil", "exert", "their", "anti-arrhythmic", "and", "C0042397#ent", "<e2>", "restricting", "Ca(2+)", "into", "myocardial", "cells", "smooth", "muscle", "cells"], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [19, 20]}}
{"token": ["Adenovirus-mediated", "overexpression", "of", "SHP", "significantly", "decreased", "the", "mRNA", "levels", "of", "glucose-6-phosphase", "(", "G6Pase", ")", ",", "cholesterol", "7-alpha-hydroxylase", "CYP7A1", ")", ",", "and", "C0251211#ent", "<e1>", "PEPCK", ")", "in", "HepG2", "cells", "rat", "primary", "C0669372#ent", "<e2>", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [30, 31]}}
{"token": ["CCAAT/enhancer", "binding", "protein", "C/EBP", ")", "family", "members", "known", "to", "transactivate", "the", "gene", "encoding", "C0251211#ent", "<e1>", "PEPCK", ";", "EC", "4.1.1.32", "in", "C0669372#ent", "<e2>", "via", "promoter", "proximal", "response", "elements", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [20, 21]}}
{"token": ["Although", "a", "beta", "blocker", "not", "effective", "in", "preventing", "tilt-induced", "hypotension", "bradycardia", ",", "C0733394#ent", "<e1>", "alpha-1", "stimulant", ")", "or", "C1161352#ent", "<e2>", "prevented", "it", "."], "h": {"id": "C0733394", "name": "C0733394#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [18, 19]}}
{"token": ["Using", "dominant", "negative", "and", "C0907533#ent", "<e1>", "active", "forms", "the", "protein", "kinase", "A", "subunits", "we", "also", "show", "that", "expression", "of", "C0162359#ent", "<e2>", "as", "well", "as", "of", "other", "sonic", "hedgehog", "targets", ",", "is", "regulated", "by", "protein", "kinase", "A", "activity", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162359", "name": "C0162359#ent", "pos": [19, 20]}}
{"token": ["To", "asses", "haemodynamic", "effects", "short", "and", "long", "term", "amiodarone", "on", "ischaemia-induced", "left", "ventricular", "dysfunction", "to", "compare", "them", "with", "those", "of", "glyceryl", "trinitrate", "C0885378#ent", "<e1>", ")", ",", "beta-blocking", "and", "calcium", "antagonist", "drugs", "19", "patients", "with", "C0264694#ent", "<e2>", "studied", "."], "h": {"id": "C0885378", "name": "C0885378#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0264694", "name": "C0264694#ent", "pos": [34, 35]}}
{"token": ["In", "contrast", ",", "the", "bona", "fide", "PPARgamma", "ligands", "TZDs", ";", "C0289313#ent", "<e1>", ",", "pioglitazone", "and", "C1257987#ent", "<e2>", ")", "barely", "inhibited", "proinflammatory", "cytokines", "but", "strongly", "enhanced", "the", "production", "of", "IL-1Ra", "from", "PMA-stimulated", "THP-1", "cells", "."], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [10, 11]}, "relation": "has_structural_class", "t": {"id": "C1257987", "name": "C1257987#ent", "pos": [15, 16]}}
{"token": ["Only", "one", "study", ",", "enrolling", "patients", "with", "transient", "C0007787#ent", "<e1>", "minor", "stroke", ",", "has", "examined", "C0004057#ent", "<e2>", "in", "a", "daily", "dose", "approximately", "325", "mg", "."], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [15, 16]}}
{"token": ["These", "effects", "did", "not", "necessarily", "occurred", "in", "every", "instance", "the", "C1254351#ent", "<e1>", "was", "administered", ",", "being", "present", "in", "one", "C0009952#ent", "<e2>", "episode", "and", "not", "in", "the", "others", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [19, 20]}}
{"token": ["The", "LMs", "showed", "eosinophilic", "cytoplasm", ",", "and", "were", "positive", "for", "desmin", "and", "C0026847#ent", "<e1>", ",", "and", "negative", "for", "C1704888#ent", "<e2>", "and", "CD34", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704888", "name": "C1704888#ent", "pos": [18, 19]}}
{"token": ["Both", "C1704920#ent", "<e1>", "endogenous", "released", "C1705518#ent", "<e2>", "in", "the", "ARC", "are", "involved", "in", "the", "nociceptive", "modulation", "inflammation", "."], "h": {"id": "C1704920", "name": "C1704920#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705518", "name": "C1705518#ent", "pos": [5, 6]}}
{"token": ["Combining", "C1704920#ent", "<e1>", "and", "Y5", "antagonists", "blocked", "actions", "of", "C1705518#ent", "<e2>", "entirely", ",", "but", "the", "Y2", "antagonist", "completely", "blocked", "actions", "of", "C1705518#ent", "<e2>", "in", "some", "neurons", "."], "h": {"id": "C1704920", "name": "C1704920#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705518", "name": "C1705518#ent", "pos": [9, 10]}}
{"token": ["To", "be", "more", "specific", ",", "NPY-mediated", "vascular", "smooth", "muscle", "cell", "growth", "leading", "to", "neointima", "formation", ",", "involves", "C1704920#ent", "<e1>", "and", "Y1", "receptors", "while", "the", "angiogenic", "effects", "C1705518#ent", "<e2>", "include", "Y2", "and", "Y5", "receptor", "activation", "."], "h": {"id": "C1704920", "name": "C1704920#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705518", "name": "C1705518#ent", "pos": [26, 27]}}
{"token": ["Our", "results", "suggest", "that", "C1333197#ent", "<e1>", "direct", "PI-3K", "sites", "activate", "C0812228#ent", "<e2>", "via", "a", "Shc/Grb2/Gab2/PI-3", "K", "pathway", ",", "thereby", "regulating", "cell", "survival", "proliferation", "."], "h": {"id": "C1333197", "name": "C1333197#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [10, 11]}}
{"token": ["C1321914#ent", "<e1>", "is", "synthesized", "as", "its", "C0546849#ent", "<e2>", "and", "derivatized", "using", "mercaptoethanol", "and", "o-phthalaldehyde", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [6, 7]}}
{"token": ["Serum", "concentrations", "of", "IGF-1", "were", "lower", "in", "GB", "rats", "treated", "with", "enalapril", ",", "alpha-methyldopa", "and", "C0033497#ent", "<e1>", "(", "p<0.01", ")", ",", "but", "not", "in", "those", "treated", "with", "C0287041#ent", "<e2>", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [27, 28]}}
{"token": ["Moreover", ",", "C0011991#ent", "<e1>", "weight", "loss", "malnutrition", "may", "also", "contribute", "to", "the", "C0221026#ent", "<e2>"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0221026", "name": "C0221026#ent", "pos": [12, 13]}}
{"token": ["Studies", "on", "C0038761#ent", "<e1>", "inhibitors", "of", "human", "C0064833#ent", "<e2>", "HLE", ")", "have", "been", "extended", "to", "the", "new", "class", "of", "cephem", "4-ketones", "."], "h": {"id": "C0038761", "name": "C0038761#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [7, 8]}}
{"token": ["This", "study", "was", "designed", "to", "evaluate", "the", "myocardial", "damage", "C0005944#ent", "<e1>", "the", "left", "ventricle", "patients", "with", "C0264766#ent", "<e2>"], "h": {"id": "C0005944", "name": "C0005944#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0264766", "name": "C0264766#ent", "pos": [16, 17]}}
{"token": ["Atropine", "sulfate", "C1161352#ent", "<e1>", "methylnitrate", "and", "C1418952#ent", "<e2>", "inhibited", "the", "binding", "of", "both", "radioligands", "with", "Hill", "slopes", "n(H", ")", ")", "close", "to", "unity", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418952", "name": "C1418952#ent", "pos": [6, 7]}}
{"token": ["We", "have", "used", "the", "bone", "marrow", "reconstitution", "leukemogenesis", "model", "to", "test", "the", "hypothesis", "that", "C0812385#ent", "<e1>", "sequences", "influence", "the", "ability", "of", "activated", "C3890208#ent", "<e2>", "to", "transform", "different", "types", "of", "hematopoietic", "cells"], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3890208", "name": "C3890208#ent", "pos": [22, 23]}}
{"token": ["In", "conclusion", ",", "C0532261#ent", "<e1>", "significantly", "attenuated", "the", "late", "asthmatic", "response", "to", "C3274161#ent", "<e2>", "challenge", "in", "the", "absence", "of", "any", "bronchodilatory", "or", "histamine", "antagonist", "effect", "."], "h": {"id": "C0532261", "name": "C0532261#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [12, 13]}}
{"token": ["We", "report", "here", "that", "erythropoietin-induced", "activation", "of", "the", "immediate", "early", "gene", "c-myc", "protein", "kinase", "C", "that", "the", "binding", "of", "C1366564#ent", "<e1>", "causes", "rapid", "phosphorylation", "of", "the", "major", "protein", "kinase", "C", "substrate", "C1538092#ent", "<e2>", "."], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1538092", "name": "C1538092#ent", "pos": [31, 32]}}
{"token": ["No", "significant", "in", "clinical", "and", "ECG", "characteristics", "of", "the", "study", "and", "control", "groups", "found", "regarding", "presence", "or", "type", "of", "organic", "heart", "disease", "C0024115#ent", "<e1>", "hypertension", ",", "medication", "use", "intraventricular", "conduction", "delay", "abnormal", "Q", "waves", "C0149721#ent", "<e2>", "or", "QT", "prolongation", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0149721", "name": "C0149721#ent", "pos": [34, 35]}}
{"token": ["Esomeprazole", "provided", "better", "control", "of", "intragastric", "pH", "omeprazole", ",", "C2348248#ent", "<e1>", "and", "pantoprazole", "in", "trials", "conducted", "in", "patients", "with", "C0017168#ent", "<e2>", "GORD", ")", "or", "healthy", "volunteers", "n", "=", "20", "to", "115", ")", "."], "h": {"id": "C2348248", "name": "C2348248#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [19, 20]}}
{"token": ["VirB6", "is", "essential", "for", "DNA", "transfer", "is", "a", "C0021699#ent", "<e1>", "at", "least", "four", "C1417326#ent", "<e2>"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417326", "name": "C1417326#ent", "pos": [13, 14]}}
{"token": ["The", "C0021699#ent", "<e1>", "expressed", "on", "all", "T", "cells", "the", "C1417326#ent", "<e2>", "subset", "of", "B", "cells", "modulates", "antigen", "receptor-mediated", "activation", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417326", "name": "C1417326#ent", "pos": [9, 10]}}
{"token": ["Six", "cases", "in", "Group", "A", "positive", "for", "C0242853#ent", "<e1>", "with", "two", "strong", "positive", ")", ",", "three", "for", "C1705526#ent", "<e2>", ",", "neu", "and", "jun", "each", ",", "and", "one", "for", "p16", "."], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "emphasize", "the", "importance", "of", "considering", "MEB", "and", "searching", "for", "C1826644#ent", "<e1>", "mutations", "in", "WWS", "or", "other", "C1416776#ent", "<e2>", "patients", "worldwide", "."], "h": {"id": "C1826644", "name": "C1826644#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416776", "name": "C1416776#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "C1826644#ent", "<e1>", "a", "type", "of", "C1416776#ent", "<e2>", "muscle-eye-brain", "disease", "MEB", ")", "."], "h": {"id": "C1826644", "name": "C1826644#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416776", "name": "C1416776#ent", "pos": [8, 9]}}
{"token": ["Mutations", "in", "protein-O-mannose-beta1,2-N-acetylglucosaminyltransferase", "1", "(", "C1826644#ent", "<e1>", ")", "have", "been", "found", "in", "muscle-eye-brain", "disease", "a", "C1416776#ent", "<e2>", "structural", "eye", "brain", "defects", "and", "severe", "mental", "retardation"], "h": {"id": "C1826644", "name": "C1826644#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416776", "name": "C1416776#ent", "pos": [15, 16]}}
{"token": ["C1708477#ent", "<e1>", "the", "process", "that", "differentially", "modifies", "the", "parental", "alleles", "certain", "C0678933#ent", "<e2>", "the", "parental", "germlines", "."], "h": {"id": "C1708477", "name": "C1708477#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0678933", "name": "C0678933#ent", "pos": [11, 12]}}
{"token": ["C1415063#ent", "<e1>", "cleavage/GHBP", "shedding", "is", "effected", "by", "TACE", "(", "TNF-alpha", "converting", "C0014442#ent", "<e2>", ")", ",", "a", "metalloproteinase", "of", "the", "ADAM", "family", "and", "possibly", "related", "enzymes", "."], "h": {"id": "C1415063", "name": "C1415063#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "all", "C3H/HeJ", "mice", "C0029882#ent", "<e1>", "all", "time", "points", ",", "and", "increasing", "bacterial", "counts", "from", "C0029883#ent", "<e2>", "detected", "in", "C3H/HeJ", "mice", "h", "after", "injection", "."], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0029883", "name": "C0029883#ent", "pos": [17, 18]}}
{"token": ["TCR/CD28", "engagement", "induces", "the", "formation", "of", "endogenous", "Lck-Dlgh1-Zap70-Wiskott-Aldrich", "syndrome", "protein", "(", "C1705616#ent", "<e1>", ")", "complexes", "in", "which", "Dlgh1", "acts", "to", "facilitate", "interactions", "of", "C0919477#ent", "<e2>", "with", "Zap70", "and", "C1705616#ent", "<e1>", "."], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [11, 12]}}
{"token": ["Although", "the", "current", "paradigm", "delegates", "histone", "deacetylases", "HDACs", ")", "to", "the", "role", "of", "transcriptional", "co-repressors", "we", "recently", "showed", "that", "C3539637#ent", "<e1>", "activity", "was", "necessary", "for", "expression", "of", "the", "hematopoietic", "transcription", "factor", "C0919490#ent", "<e2>", "."], "h": {"id": "C3539637", "name": "C3539637#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [31, 32]}}
{"token": ["All", "3", "C1414926#ent", "<e1>", "autoantibody", "positive", "C0085207#ent", "<e2>", "patients", "subsequently", "developed", "IDDM", "after", "a", "median", "of", "14", "months", "(", "range", "4", "-", "34", ")", "."], "h": {"id": "C1414926", "name": "C1414926#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [6, 7]}}
{"token": ["Moreover", ",", "the", "VEGF-induced", "C0669365#ent", "<e1>", "expression", "was", "reduced", "by", "the", "C0298346#ent", "<e2>", ",", "MAPK", "pathway", "inhibitor", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0298346", "name": "C0298346#ent", "pos": [11, 12]}}
{"token": ["In", "thoracic", "aorta", "experiments", ",", "the", "apparent", "pA2", "values", "of", "C0001640#ent", "<e1>", "blockade", "were", "7.05+/-0.25", "and", "6.87+/-0.08", "for", "eugenodilol", "and", "C0699440#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0699440", "name": "C0699440#ent", "pos": [20, 21]}}
{"token": ["These", "PMN", "functional", "and", "C1540034#ent", "<e1>", "observations", "suggest", "that", "of", "the", "three", "C3539185#ent", "<e2>", "studied", ",", "methylprednisolone", "appears", "most", "deleterious", "to", "the", "PMN", "phagocytic", "and", "bactericidal", "activity"], "h": {"id": "C1540034", "name": "C1540034#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539185", "name": "C3539185#ent", "pos": [12, 13]}}
{"token": ["2", "C0055891#ent", "<e1>", ",", "a", "novel", "1,5", "C0005064#ent", "<e2>", ",", "and", "diazepam", "were", "compared", "with", "placebo", "in", "a", "double-blind", "group", "trial", "in", "general", "practice", "which", "was", "designed", "to", "avoid", "as", "many", "confounding", "variables", "possible", "."], "h": {"id": "C0055891", "name": "C0055891#ent", "pos": [1, 2]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [7, 8]}}
{"token": ["To", "determine", "the", "prevalence", "and", "risk", "factors", "C0700345#ent", "<e1>", "VC", ")", "among", "women", "seeking", "primary", "care", "C2314882#ent", "<e2>"], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [16, 17]}}
{"token": ["To", "study", "their", "biological", "function", "to", "create", "animal", "models", "these", "C1428880#ent", "<e1>", "several", "strains", "of", "mice", "mutated", "in", "the", "C1512488#ent", "<e2>", "Brca1", "and", "Brca2", "have", "been", "generated", "by", "gene", "targeting"], "h": {"id": "C1428880", "name": "C1428880#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [19, 20]}}
{"token": ["The", "C0633225#ent", "<e1>", "superoxide", "dismutase", "SOD", ")", ",", "peroxidase", "(", "C1418945#ent", "<e2>", ")", "and", "catalase", "(", "CAT", ")", "were", "increased", "under", "salinity", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418945", "name": "C1418945#ent", "pos": [10, 11]}}
{"token": ["The", "evaluation", "of", "effect", "of", "nebulized", "C0543495#ent", "<e1>", "should", "take", "into", "account", "both", "C1457887#ent", "<e2>", "(", "basic", ")", "spirometry", "parameters", "of", "airway", "obstruction", "as", "FEV1", "PEF", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [13, 14]}}
{"token": ["A", "case", "of", "C0041323#ent", "<e1>", "of", "the", "cervical", "spine", "C0032586#ent", "<e2>", "is", "described", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032586", "name": "C0032586#ent", "pos": [9, 10]}}
{"token": ["The", "results", "demonstrated", "that", "C1520007#ent", "<e1>", "capable", "of", "downregulating", "C1422630#ent", "<e2>", ",", "resulting", "in", "impressive", "anticancer", "effects"], "h": {"id": "C1520007", "name": "C1520007#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422630", "name": "C1422630#ent", "pos": [9, 10]}}
{"token": ["Characteristics", "of", "the", "three", "major", "ammonia", "assimilatory", "enzymes", ",", "glutamate", "dehydrogenase", "C1415455#ent", "<e1>", ")", ",", "glutamine", "synthetase", "GS", ")", "and", "C1449106#ent", "<e2>", "GO-GAT", ")", "in", "Corynebacterium", "callunae", "NCIB", "10338", ")", "were", "examined", "."], "h": {"id": "C1415455", "name": "C1415455#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1449106", "name": "C1449106#ent", "pos": [20, 21]}}
{"token": ["In", "transfection", "experiments", "C1422267#ent", "<e1>", "HERV-K", "cDNA-based", "expression", "vectors", "yielded", "the", "proteins", "C0017346#ent", "<e2>", "and", "cORF", "whereas", "HERV-K10", "vectors", "yielded", "C0017346#ent", "<e2>", "alone", "."], "h": {"id": "C1422267", "name": "C1422267#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "report", "the", "identification", "of", "the", "C0255652#ent", "<e1>", "Cak", ")", "complex", "(", "C1413288#ent", "<e2>", "and", "cyclin", "H", "as", "a", "component", "of", "TFIIH", "after", "extensive", "purification", "of", "TFIIH", "by", "chromatography", "."], "h": {"id": "C0255652", "name": "C0255652#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413288", "name": "C1413288#ent", "pos": [13, 14]}}
{"token": ["Wild-type", "EF1", "was", "immobilized", "on", "a", "dextran", "matrix", "and", "the", "C2987364#ent", "<e1>", "and", "mutated", "versions", "of", "C1414295#ent", "<e2>", "were", "injected", "at", "several", "different", "concentrations", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414295", "name": "C1414295#ent", "pos": [16, 17]}}
{"token": ["The", "results", "of", "this", "study", "indicated", "that", "indomethacin", "produced", "C0021831#ent", "<e1>", "rather", "than", "C0038354#ent", "<e2>", "when", "used", "chronically", "in", "clinically", "relevant", "doses", "in", "rats", "."], "h": {"id": "C0021831", "name": "C0021831#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038354", "name": "C0038354#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "pancreatic", "and", "P.", "aeruginosa", "C0030306#ent", "<e1>", "act", "synergistically", "during", "the", "initial", "stages", "of", "C0010495#ent", "<e2>", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010495", "name": "C0010495#ent", "pos": [15, 16]}}
{"token": ["The", "foregoing", "characteristics", "of", "the", "human", "leukocyte", "elastase", "that", "it", ",", "rather", "than", "pancreatic", "(", "serum", ")", "C0030306#ent", "<e1>", ",", "may", "mediate", "pathological", "C0010495#ent", "<e2>", "during", "acute", "arteritis", "man", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010495", "name": "C0010495#ent", "pos": [23, 24]}}
{"token": ["The", "C0029118#ent", "<e1>", "human", "pathogen", "Pseudomonas", "aeruginosa", "a", "variety", "of", "virulence", "factors", "including", "exotoxin", "A", "C0699918#ent", "<e2>", ",", "alkaline", "protease", "alginate", ",", "phospholipases", ",", "and", "extracellular", "rhamnolipids", "."], "h": {"id": "C0029118", "name": "C0029118#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [15, 16]}}
{"token": ["An", "important", "virulence", "factor", "the", "C0029118#ent", "<e1>", "human", "pathogen", "Pseudomonas", "aeruginosa", "C0699918#ent", "<e2>", ",", "a", "secreted", "thermolysin-like", "neutral", "zinc-metalloprotease", "(", "TNP", ")", "."], "h": {"id": "C0029118", "name": "C0029118#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [11, 12]}}
{"token": ["The", "C0720099#ent", "<e1>", "of", "the", "anesthetic", "effect", "significantly", "longer", "in", "the", "groups", "where", "C0040610#ent", "<e2>", "was", "injected", "into", "the", "surgical", "site", "215", "and", "252", "min", ")", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0040610", "name": "C0040610#ent", "pos": [13, 14]}}
{"token": ["In", "an", "open", ",", "prospective", ",", "randomized", "study", "the", "quality", "and", "C0720099#ent", "<e1>", "of", "analgesia", "and", "the", "side", "effects", "associated", "with", "C0040610#ent", "<e2>", "were", "compared", "with", "those", "of", "metimazole", "in", "acute", "ureteral", "colic", "60", "patients", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040610", "name": "C0040610#ent", "pos": [21, 22]}}
{"token": ["The", "biological", "and", "clinical", "results", "that", "benzbromarone", "should", "be", "considered", "as", "the", "C1254351#ent", "<e1>", "of", "choice", "in", "the", "majority", "of", "gouty", "and", "C0041983#ent", "<e2>", "patients", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041983", "name": "C0041983#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "it", "would", "appear", "that", "tienilic", "acid", "a", "potentially", "valuable", "C1254351#ent", "<e1>", "which", "may", "have", "a", "special", "role", "in", "patients", "with", "C0041983#ent", "<e2>", "and", "hypertension", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041983", "name": "C0041983#ent", "pos": [22, 23]}}
{"token": ["BOF-4272", ",", "(+/-)-8-(3-methoxy-4-phenylsulfinylphenyl", ")", "pyrazolo[1,5-a]-1,3,5-triazine-4(1H)-one", ")", ",", "is", "a", "new", "C1254351#ent", "<e1>", "intended", "for", "the", "treatment", "of", "C0041983#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041983", "name": "C0041983#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "no", "direct", "C1415900#ent", "<e1>", "effect", "on", "C0032002#ent", "<e2>", "ACTH", "secretion", "could", "be", "observed", "in", "vitro.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [9, 10]}}
{"token": ["We", "identified", "eight", "novel", "mutations", "in", "the", "C0038302#ent", "<e1>", "different", "in", "nature", "and", "spread", "throughout", "the", "C0079429#ent", "<e2>", "."], "h": {"id": "C0038302", "name": "C0038302#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["Since", "the", "CYP17", "gene", "the", "C0038302#ent", "<e1>", "which", "mediates", "17alpha-hydroxylase", "and", "17,20-lyase", "activities", "the", "androgen", "biosynthesis", "pathway", "sequence", "variations", "the", "C0079429#ent", "<e2>", "and", "association", "with", "increased", "risk", "to", "prostate", "cancer", "been", "studied", "."], "h": {"id": "C0038302", "name": "C0038302#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [20, 21]}}
{"token": ["Recent", "advances", ",", "principally", "in", "the", "authors", "'", "laboratories", ",", "have", "resulted", "in", "the", "cloning", "of", "the", "human", "C0038302#ent", "<e1>", "the", "identification", "of", "mutations", "in", "its", "C0079429#ent", "<e2>", "that", "cause", "Vitamin", "D", "Rickets", "type"], "h": {"id": "C0038302", "name": "C0038302#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [26, 27]}}
{"token": ["The", "aim", "of", "this", "open", "study", "to", "evaluate", "the", "efficacy", "and", "safety", "of", "new", "topical", "corticosteroid", "Nasonex", "C0066700#ent", "<e1>", "in", "allergic", ",", "C0018621#ent", "<e2>"], "h": {"id": "C0066700", "name": "C0066700#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0018621", "name": "C0018621#ent", "pos": [22, 23]}}
{"token": ["The", "onset", "of", "action", "of", "C0066700#ent", "<e1>", "approximately", "7", "hours", "in", "patients", "with", "C0018621#ent", "<e2>"], "h": {"id": "C0066700", "name": "C0066700#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018621", "name": "C0018621#ent", "pos": [13, 14]}}
{"token": ["Osteomalacia", "is", "associated", "with", "chronic", "pyelonephritis", "obstruction", "as", "C0242634#ent", "<e1>", "and", "with", "acidosis", ",", "C0020598#ent", "<e2>", "and", "normophosphataemia", "(", "as", "opposed", "to", "hyperphosphataemia", ")", "."], "h": {"id": "C0242634", "name": "C0242634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020598", "name": "C0020598#ent", "pos": [14, 15]}}
{"token": ["Cephalic", "phase", "insulin", "release", "(", "C1516250#ent", "<e1>", ")", ",", "in", "particular", ",", "might", "be", "related", "to", "C0020175#ent", "<e2>", "and", "overeating", "."], "h": {"id": "C1516250", "name": "C1516250#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020175", "name": "C0020175#ent", "pos": [16, 17]}}
{"token": ["Inactivation", "of", "C0071511#ent", "<e1>", "increased", "the", "sensitivity", "to", "C0031957#ent", "<e2>", "."], "h": {"id": "C0071511", "name": "C0071511#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [8, 9]}}
{"token": ["This", "ranking", "is", "identical", "to", "that", "reported", "for", "purified", "PAO", "and", "distinctly", "different", "from", "the", "recently", "identified", "C0071511#ent", "<e1>", "SMO", ")", ",", "which", "prefers", "C0031957#ent", "<e2>", "over", "N1-acetylspermine", "."], "h": {"id": "C0071511", "name": "C0071511#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [24, 25]}}
{"token": ["T1", "weighted", "spin", "echo", "(", "C1414863#ent", "<e1>", ")", "images", "and", "3D", "gradient", "echo", "(", "C0385569#ent", "<e2>", "40", "degrees", "3D", ")", "images", "were", "obtained", "."], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0385569", "name": "C0385569#ent", "pos": [14, 15]}}
{"token": ["The", "smooth", "muscle", "cells", "isolated", "from", "human", "umbilical", "cord", "arteries", "twice", "by", "an", "enzyme", "mixture", "collagenase", ",", "trypsin", ",", "C0699918#ent", "<e1>", ",", "and", "DNAase", "with", "addition", "of", "C0040495#ent", "<e2>"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0040495", "name": "C0040495#ent", "pos": [27, 28]}}
{"token": ["These", "data", "provide", "the", "first", "direct", "evidence", "that", "C1416933#ent", "<e1>", "may", "act", "as", "an", "C0207564#ent", "<e2>", "."], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0207564", "name": "C0207564#ent", "pos": [14, 15]}}
{"token": ["The", "anthrax", "lethal", "factor", "C1416933#ent", "<e1>", ")", "is", "a", "Zn2", "+", "C0207564#ent", "<e2>", "specific", "for", "mitogen-activated", "protein", "kinase", "kinases", "MAPKKs", ")", ",", "which", "are", "cleaved", "within", "their", "N", "termini", "."], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0207564", "name": "C0207564#ent", "pos": [11, 12]}}
{"token": ["Polymorphisms", "in", "the", "C1335805#ent", "<e1>", "chromosome", "7", "are", "also", "associated", "with", "C0055461#ent", "<e2>", "and", "18", "(", "75", "%", ")", "of", "the", "24", "parasite", "samples", "each", "had", "the", "cg2", "and", "pfmdr1", "polymorphisms", "."], "h": {"id": "C1335805", "name": "C1335805#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [11, 12]}}
{"token": ["Among", "the", "emerging", "agents", "and", "therapeutic", "targets", "were", "C1704467#ent", "<e1>", "antisense", "therapy", "RAF", "kinases", "heat-shock", "proteins", "thalidomide", "and", "newer", "immunomodulatory", "drugs", "cytotoxic", "T", "lymphocyte", "antigen-4", "antibody", "C3215046#ent", "<e2>"], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3215046", "name": "C3215046#ent", "pos": [26, 27]}}
{"token": ["A", "biomic", "approach", "integrating", "three", "independent", "methods", ",", "DNA", "microarray", "proteomics", "and", "bioinformatics", ",", "is", "used", "to", "study", "the", "differentiation", "of", "C1366587#ent", "<e1>", "macrophages", "when", "induced", "by", "12-O-tetradecanoyl-phorbol-13-acetate", "(", "C0078956#ent", "<e2>", ")", "."], "h": {"id": "C1366587", "name": "C1366587#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [29, 30]}}
{"token": ["It", "was", "identified", "by", "amino", "acid", "sequencing", "a", "C2717971#ent", "<e1>", "related", "to", "C1333877#ent", "<e2>", "of", "T", "lymphocytes"], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1333877", "name": "C1333877#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "C1335271#ent", "<e1>", "and", ",", "by", "analogy", ",", "the", "highly", "C1334043#ent", "<e2>", "PGHS-2", "are", "luminal", "ER", "proteins"], "h": {"id": "C1335271", "name": "C1335271#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["Here", ",", "we", "show", "that", "trimethylguanosine", "synthase", "1", "C1335271#ent", "<e1>", ")", ",", "the", "human", "C1334043#ent", "<e2>", "of", "the", "yeast", "snRNA", "cap", "hypermethylase", ",", "interacts", "directly", "with", "the", "survival", "of", "motor", "neuron", "SMN", ")", "protein", "."], "h": {"id": "C1335271", "name": "C1335271#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}}
{"token": ["C0024031#ent", "<e1>", "responsive", "to", "therapies", "that", "are", "effective", "for", "C0029408#ent", "<e2>", "in", "other", "locations", "."], "h": {"id": "C0024031", "name": "C0024031#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [9, 10]}}
{"token": ["The", "experiments", "involved", "patients", "suffering", "from", "C0024031#ent", "<e1>", "as", "well", "as", "other", "C0029408#ent", "<e2>", "and", "healthy", "patients", "."], "h": {"id": "C0024031", "name": "C0024031#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [12, 13]}}
{"token": ["Type", "III", "collagen", "detected", "obviously", "in", "C0030848#ent", "<e1>", "was", "also", "present", "in", "C0242998#ent", "<e2>"], "h": {"id": "C0030848", "name": "C0030848#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242998", "name": "C0242998#ent", "pos": [12, 13]}}
{"token": ["The", "ratios", "of", "type", "III", "to", "type", "I", "collagen", "significantly", "higher", "in", "C0030848#ent", "<e1>", "there", "was", "a", "moderate", "increase", "in", "C0242998#ent", "<e2>"], "h": {"id": "C0030848", "name": "C0030848#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242998", "name": "C0242998#ent", "pos": [20, 21]}}
{"token": ["We", "report", "here", "that", "spermine", ",", "spermidine", ",", "and", ",", "to", "a", "lesser", "degree", ",", "the", "C0284559#ent", "<e1>", "viricidal", "to", "HIV-1", "when", "combined", "with", "C0026454#ent", "<e2>", "myeloperoxidase", "."], "h": {"id": "C0284559", "name": "C0284559#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [24, 25]}}
{"token": ["Cytostatic", "effect", "C0284559#ent", "<e1>", "in", "cell", "culture", "dependent", "on", "the", "content", "of", "C0026454#ent", "<e2>", "serum", "."], "h": {"id": "C0284559", "name": "C0284559#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [12, 13]}}
{"token": ["There", "was", "some", "correlation", "between", "the", "cytocidal", "activity", "of", "C0284559#ent", "<e1>", "and", "the", "concentrations", "of", "C0026454#ent", "<e2>", "the", "serum", "."], "h": {"id": "C0284559", "name": "C0284559#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [15, 16]}}
{"token": ["From", "Western", "blotting", "we", "learned", "that", "the", "expression", "of", "C1427656#ent", "<e1>", "in", "the", "Deltaree1", "strain", "was", "different", "from", "that", "in", "C2987364#ent", "<e2>", "strains", "and", "that", "C1427656#ent", "<e1>", "expression", "was", "not", "changed", "by", "glucose", "stimulation"], "h": {"id": "C1427656", "name": "C1427656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}}
{"token": ["Activation", "of", "the", "C1382029#ent", "<e1>", "to", "phosphorylation", "of", "cyclase", "response", "element", "binding", "proteins", "P-CREBs", ")", "which", "then", "bind", "C1413777#ent", "<e2>", "in", "these", "genes", "and", "induce", "transcription", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413777", "name": "C1413777#ent", "pos": [18, 19]}}
{"token": ["Nitrendipine", ",", "C0068753#ent", "<e1>", "and", "verapamil", "inhibited", "urethral", "contractions", "induced", "by", "C0006945#ent", "<e2>", "and", "KCl", "to", "the", "same", "degree", "as", "did", "nifedipine", "."], "h": {"id": "C0068753", "name": "C0068753#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [11, 12]}}
{"token": ["We", "were", "interested", "to", "see", "if", "C0011777#ent", "<e1>", "would", "be", "as", "effective", "as", "C0010621#ent", "<e2>", "treating", "hirsutism", "in", "selected", "patients", "with", "adrenal", "pathogenesis"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010621", "name": "C0010621#ent", "pos": [13, 14]}}
{"token": ["Thirteen", "girls", "and", "two", "boys", "with", "CAH", "due", "to", "21-hydroxylase", "deficiency", "treated", "with", "different", "treatments", ",", "hydrocortisone", "(", "HC", ")", ",", "C0011777#ent", "<e1>", "(", "DXM", ")", "and", "C0010621#ent", "<e2>", "CA", ")", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0010621", "name": "C0010621#ent", "pos": [27, 28]}}
{"token": ["Promoter", "activity", "an", "increased", "response", "with", "a", "stepwise", "elevation", "of", "transfected", "C1705050#ent", "<e1>", "expression", "or", "by", "treatment", "with", "increasing", "concentrations", "of", "C1418938#ent", "<e2>", "(", "max", ",", "250", "ng/ml", ")", "."], "h": {"id": "C1705050", "name": "C1705050#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [21, 22]}}
{"token": ["C1412709#ent", "<e1>", "(", "B2M", ",", "an", "invariant", "C0017355#ent", "<e2>", "was", "absent", "in", "all", "cases", "of", "basal", "cell", "carcinoma"], "h": {"id": "C1412709", "name": "C1412709#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [7, 8]}}
{"token": ["We", "prepared", "single-labeled", "FITC", "derivatives", "of", "beta-2-microglobulin", "(", "C1412709#ent", "<e1>", "and", "examined", "their", "interactions", "with", "C0017355#ent", "<e2>", "living", "cells"], "h": {"id": "C1412709", "name": "C1412709#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [15, 16]}}
{"token": ["We", "prepared", "single-labeled", "FITC", "derivatives", "of", "C1412709#ent", "<e1>", "(", "b2m", "and", "examined", "their", "interactions", "with", "C0017355#ent", "<e2>", "living", "cells"], "h": {"id": "C1412709", "name": "C1412709#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [15, 16]}}
{"token": ["Specific", "mutations", "in", "the", "human", "C1826449#ent", "<e1>", "Blau", "syndrome", "an", "autosomal", "dominant", "form", "of", "uveitis", ",", "C0029408#ent", "<e2>", ",", "and", "dermatitis", "."], "h": {"id": "C1826449", "name": "C1826449#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [16, 17]}}
{"token": ["An", "inhibitor", "of", "C0006784#ent", "<e1>", "blocked", "both", "the", "decrease", "of", "intact", "C1415300#ent", "<e2>", "and", "the", "increase", "of", "the", "low", "molecular", "weight", ",", "whereas", "neither", "caspase", "nor", "cathepsin", "inhibitors", "an", "effect", "on", "these", "events", "."], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415300", "name": "C1415300#ent", "pos": [11, 12]}}
{"token": ["Protease-activated", "receptor-2", "C1417826#ent", "<e1>", ")", "acts", "as", "a", "receptor", "for", "trypsin", "and", "C1447694#ent", "<e2>"], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [12, 13]}}
{"token": ["C1417826#ent", "<e1>", "is", "cleaved", "by", "proteases", "with", "C1447694#ent", "<e2>", "not", "by", "thrombin", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [7, 8]}}
{"token": ["In", "order", "to", "detect", "possible", "underlying", "C0522274#ent", "<e1>", "25", "patients", "with", "C0004030#ent", "<e2>", "were", "subjected", "to", "an", "immunological", "screening", "program", "."], "h": {"id": "C0522274", "name": "C0522274#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [11, 12]}}
{"token": ["Peptide", "1", "inhibited", "C0249866#ent", "<e1>", "not", "CaM", "kinase", "II", "whereas", "C0030956#ent", "<e2>", "inhibited", "CaM", "kinase", "II", "but", "only", "partially", "inhibited", "C0249866#ent", "<e1>", "a", "more", "than", "10-fold", "higher", "concentration", "."], "h": {"id": "C0249866", "name": "C0249866#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}}
{"token": ["Cytoplasmic", "tyrosine", "residues", "Ig", "beta", "required", "for", "recruitment", "and", "activation", "of", "ZAP-70", ",", "but", "these", "C3539946#ent", "<e1>", "not", "essential", "for", "the", "activation", "of", "Fyn", "and", "C0919477#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0919477", "name": "C0919477#ent", "pos": [25, 26]}}
{"token": ["The", "clinical", "efficacy", "a", "topical", "preparation", "of", "beclomethasone", "dipropionate", "C0004906#ent", "<e1>", ")", "powder", "and", "a", "mucous", "membrane", "adhesive", "agent", "(", "C4281713#ent", "<e2>", ",", "HPC", ")", "for", "nasal", "polyps", "examined", "."], "h": {"id": "C0004906", "name": "C0004906#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4281713", "name": "C4281713#ent", "pos": [20, 21]}}
{"token": ["Importantly", ",", "the", "genes", "for", "TNF-alpha", ",", "C1366571#ent", "<e1>", ",", "and", "MHC", "class", "II", "but", "not", "ICAM-1", "or", "MHC", "class", "I", "contain", "C1511573#ent", "<e2>", "CRE", ")", "consensus", "motifs", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [22, 23]}}
{"token": ["Calcium", "5", "also", "partially", "abolished", "effects", "of", "PTH", "to", "activate", "C0001492#ent", "<e1>", "to", "inhibit", "C1413038#ent", "<e2>"], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413038", "name": "C1413038#ent", "pos": [14, 15]}}
{"token": ["cAMP", "also", "induced", "a", "persistent", "activation", "of", "C0001492#ent", "<e1>", "growth", "stage", "cells", "contain", "only", "low", "levels", "of", "cAMP", "receptor", "1", "C1413038#ent", "<e2>", ")", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413038", "name": "C1413038#ent", "pos": [20, 21]}}
{"token": ["Eighty", "consecutive", "sporadic", "C3810599#ent", "<e1>", "patients", "from", "the", "C0028850#ent", "<e2>", "clinics", "of", "two", "major", "tertiary", "institutions", "the", "country", "were", "included", "."], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028850", "name": "C0028850#ent", "pos": [8, 9]}}
{"token": ["The", "National", "Tuberculosis", "Prevalence", "Survey", "done", "in", "1997", "(", "1997", "C1836075#ent", "<e1>", ")", "revealed", "that", "the", "magnitude", "of", "C0041323#ent", "<e2>", "in", "the", "Philippines", "hardly", "declined", "between", "1982", "and", "1997", "."], "h": {"id": "C1836075", "name": "C1836075#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [18, 19]}}
{"token": ["In", "this", "report", "we", "demonstrate", "that", "Raf-1", "and", "MAP", "or", "C4082284#ent", "<e1>", "MEK", ")", ",", "key", "C1332794#ent", "<e2>", "the", "Ras", "cascade", "are", "activated", "subsequent", "to", "integrin-mediated", "adhesion", "mouse", "NIH", "3T3", "fibroblasts", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332794", "name": "C1332794#ent", "pos": [16, 17]}}
{"token": ["Integrin-mediated", "activation", "C4082284#ent", "<e1>", "ERK/MAP", ")", "kinase", "in", "C1332794#ent", "<e2>", "adhesion", "to", "fibronectin", "or", "laminin-10/11", "was", "down-regulated", ",", "whereas", "Akt", "activation", "increased", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332794", "name": "C1332794#ent", "pos": [8, 9]}}
{"token": ["In", "eight", "patients", "who", "lost", "or", "gained", "weight", "on", "CAPD", ",", "levels", "of", "PRA", "and", "C1414426#ent", "<e1>", "changed", "as", "expected", ",", "but", "C3536742#ent", "<e2>", "levels", "did", "not", "correlate", "with", "weight", "changes"], "h": {"id": "C1414426", "name": "C1414426#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [22, 23]}}
{"token": ["Clones", "C1705860#ent", "<e1>", "and", "CA31", "were", "also", "susceptible", "to", "C0019693#ent", "<e2>"], "h": {"id": "C1705860", "name": "C1705860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [9, 10]}}
{"token": ["C1414538#ent", "<e1>", "(", "FIB", ",", "Nop1p", "in", "yeast", ")", "is", "an", "C0025831#ent", "<e2>", "not", "only", "in", "the", "fibrillar", "region", "the", "nucleolus", "but", "also", "in", "Cajal", "bodies"], "h": {"id": "C1414538", "name": "C1414538#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025831", "name": "C0025831#ent", "pos": [11, 12]}}
{"token": ["Fibrillarin", "(", "C1414538#ent", "<e1>", ",", "Nop1p", "in", "yeast", ")", "is", "an", "C0025831#ent", "<e2>", "not", "only", "in", "the", "fibrillar", "region", "the", "nucleolus", "but", "also", "in", "Cajal", "bodies"], "h": {"id": "C1414538", "name": "C1414538#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025831", "name": "C0025831#ent", "pos": [11, 12]}}
{"token": ["Results", "also", "indicate", "the", "clinical", "potential", "VEP", "in", "the", "differential", "diagnosis", "patients", "suffering", "from", "C0015397#ent", "<e1>", "complicated", "by", "C0028840#ent", "<e2>", "suspect", "glaucoma", "and", "patients", "with", "dysthyroid", "optic", "neuropathy"], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0028840", "name": "C0028840#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "the", "efficacy", "and", "tolerability", "of", "C0537147#ent", "<e1>", "in", "the", "treatment", "of", "symptoms", "of", "C0022104#ent", "<e2>", "IBS", ")", "IBS-C", "patients", "."], "h": {"id": "C0537147", "name": "C0537147#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [15, 16]}}
{"token": ["The", "efficacy", "and", "safety", "of", "C0537147#ent", "<e1>", "has", "been", "well", "established", "in", "women", "suffering", "from", "C0022104#ent", "<e2>", "constipation", "."], "h": {"id": "C0537147", "name": "C0537147#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "the", "development", "of", "ischemic", "colitis", "a", "woman", "who", "was", "treated", "with", "C0537147#ent", "<e1>", "and", "review", "the", "relationship", "among", "ischemic", "colitis", "C0537147#ent", "<e1>", "use", ",", "and", "C0022104#ent", "<e1>"], "h": {"id": "C0537147", "name": "C0537147#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [27, 28]}}
{"token": ["In", "subacute-chronic", "forms", "of", "the", "disease", ",", "various", "types", "of", "C0017658#ent", "<e1>", "are", "observed", ",", "ranging", "from", "C0221238#ent", "<e2>", "focal", "and", "segmental", "hyalinosis", "associated", "with", "phenomena", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0221238", "name": "C0221238#ent", "pos": [17, 18]}}
{"token": ["The", "C1421313#ent", "<e1>", "concentrations", "were", "very", "similar", "to", "those", "of", "other", "C0038317#ent", "<e2>", "to", "interrupt", "gap", "junctional", "."], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [11, 12]}}
{"token": ["Most", "ICU", "patients", "are", "at", "high", "risk", "developing", "C0149871#ent", "<e1>", "thus", ",", "they", "should", "be", "considered", "C1332838#ent", "<e2>", "for", "prophylaxis", "against", "pulmonary", "emboli", "PE", ")", "."], "h": {"id": "C0149871", "name": "C0149871#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332838", "name": "C1332838#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "several", "distinct", "point", "mutations", "within", "the", "PMP22", "coding", "region", "associated", "with", "C0270911#ent", "<e1>", "and", "Dejerine-Sottas", "Syndrome", "humans", "and", "the", "Trembler", "(", "C0040961#ent", "<e2>", ")", "and", "Trembler-J", "phenotypes", "in", "mice", "."], "h": {"id": "C0270911", "name": "C0270911#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [23, 24]}}
{"token": ["The", "same", "cAMP", "augmentation", "was", "found", "in", "the", "cortical", "region", "maximum", "C1442758#ent", "<e1>", "induced", "by", "these", "C0035064#ent", "<e2>", "."], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [16, 17]}}
{"token": ["These", "results", "support", "that", "NAC", ",", "SEC", "and", "C1442758#ent", "<e1>", "are", "potent", "C0035064#ent", "<e2>", "for", "affecting", "hepatic", "biosynthesis", "TAG", "and", "cholesterol", ",", "and", "protecting", "liver", "against", "high", "saturated", "fat-associated", "oxidative", "damage", "."], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [12, 13]}}
{"token": ["Chest", "HRCT", "and", "microscopic", "picture", "of", "C1704942#ent", "<e1>", "suggested", "diagnosis", "of", "C0032298#ent", "<e2>"], "h": {"id": "C1704942", "name": "C1704942#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032298", "name": "C0032298#ent", "pos": [11, 12]}}
{"token": ["Elevation", "of", "conjugated", "serum", "bilirubin", "and", "alkaline", "phosphatase", "levels", "and", "histopathological", "confirmation", "of", "C0008372#ent", "<e1>", "cholangitis", "were", "the", "main", "characteristics", "during", "the", "episodes", "of", "C0022354#ent", "<e2>"], "h": {"id": "C0008372", "name": "C0008372#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [24, 25]}}
{"token": ["Cation", "positions", "are", "displaced", "only", "slightly", "by", "interaction", "with", "methanol", ",", "although", "somewhat", "more", "at", "the", "C3890779#ent", "<e1>", "sites", "than", "the", "C3273646#ent", "<e2>", "."], "h": {"id": "C3890779", "name": "C3890779#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3273646", "name": "C3273646#ent", "pos": [21, 22]}}
{"token": ["In", "vitro", "studies", "showed", "that", "SI", "and", "C3890779#ent", "<e1>", ",", "but", "not", "C3273646#ent", "<e2>", ",", "interact", "with", "nuclear", "proteins", "DBH-negative", "cells", "in", "a", "cell-specific", "manner", "."], "h": {"id": "C3890779", "name": "C3890779#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273646", "name": "C3273646#ent", "pos": [12, 13]}}
{"token": ["C0014230#ent", "<e1>", "the", "only", "C0950398#ent", "<e2>", "C.", "pneumoniae", "genome", ",", "was", "cloned", "into", "pET28a", "."], "h": {"id": "C0014230", "name": "C0014230#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [4, 5]}}
{"token": ["The", "specific", "C0014230#ent", "<e1>", "involved", "was", "demonstrated", "to", "be", "distinct", "from", "the", "C0950398#ent", "<e2>", "its", "rate", "of", "temperature", "inactivation", "."], "h": {"id": "C0014230", "name": "C0014230#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [12, 13]}}
{"token": ["Among", "the", "enzymes", "readily", "assayed", "are", "DNA", "and", "RNA", "polymerases", "terminal", "deoxynucleotidyl", "transferases", "nucleases", "of", "all", "varieties", "(", "e.g.", "single-strand", "specific", "C0014230#ent", "<e1>", "including", "for", "example", "C0950398#ent", "<e2>", "exonucleases", ",", "RNase", "H", "etc", ".", ")", ","], "h": {"id": "C0014230", "name": "C0014230#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [26, 27]}}
{"token": ["The", "Western-blot", "data", "revealed", "that", "oxidized", "LDL", "upregulated", "C0248813#ent", "<e1>", "JNK", ")", "phosphorylation", ",", "which", "was", "rapidly", "reversed", "by", "C0059438#ent", "<e2>", "and", "hesperetin", "."], "h": {"id": "C0248813", "name": "C0248813#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059438", "name": "C0059438#ent", "pos": [19, 20]}}
{"token": ["We", "report", "three", "cases", "of", "C0017668#ent", "<e1>", "and", "an", "additional", "case", "of", "C4054945#ent", "<e2>", "patients", "presenting", "with", "nephrotic", "syndrome", "malignancy", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C4054945", "name": "C4054945#ent", "pos": [12, 13]}}
{"token": ["1", "Goat", "isolated", "trachea", "contracted", "in", "response", "to", "C0006945#ent", "<e1>", ",", "histamine", "and", "C0091983#ent", "<e2>", "(", "an", "H(1)-receptor", "agonist", ")", "and", "relaxed", "after", "application", "of", "isoprenaline", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0091983", "name": "C0091983#ent", "pos": [13, 14]}}
{"token": ["A", "monoclonal", "antibody", "the", "purified", "58-kDa", "C1418944#ent", "<e1>", "a", "monoclonal", "antibody", "the", "C1420192#ent", "<e2>", "103", "kDa", ")", "of", "the", "neurotoxin", "reacted", "with", "the", "cross-linked", "product", "of", "161", "kDa", "in", "immunoblotting", "experiments", "."], "h": {"id": "C1418944", "name": "C1418944#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [12, 13]}}
{"token": ["administration", "of", "C0237406#ent", "<e1>", "or", "amphetamine", "in", "the", "C0022471#ent", "<e2>", "lesioned", "rats", "induced", "ipsiversive", "turning", ",", "while", "i.p", "."], "h": {"id": "C0237406", "name": "C0237406#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [8, 9]}}
{"token": ["However", ",", "G\u00f6", "6976", ",", "a", "C1826724#ent", "<e1>", "inhibitor", "relatively", "specific", "for", "conventional", "C1826724#ent", "<e1>", "isoforms", ",", "almost", "completely", "abolished", "C1720860#ent", "<e1>", "phosphorylation", "by", "PMA", "but", "only", "slightly", "inhibited", "C1720860#ent", "<e1>", "activation", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1720860", "name": "C1720860#ent", "pos": [20, 21]}}
{"token": ["Pertussis", "toxin", "increased", "the", "effect", "of", "24R,25-(OH)(2)D(3", ")", "on", "C1826724#ent", "<e1>", ",", "whereas", "GDPbetaS", "had", "no", "effect", ",", "suggesting", "that", "C1720860#ent", "<e2>", "is", "the", "isoform", "responsible", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1720860", "name": "C1720860#ent", "pos": [20, 21]}}
{"token": ["C1826724#ent", "<e1>", "inhibitors", "Ro-31", "-", "8220", "and", "bisindolylmaleimide", "I", "inhibited", "both", "PMA-induced", "C1720860#ent", "<e2>", "phosphorylation", "and", "activation", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1720860", "name": "C1720860#ent", "pos": [12, 13]}}
{"token": ["We", "here", "report", "syntheses", "of", "both", "regioisomers", "of", "the", "C1257967#ent", "<e1>", "hydnocarpin", "and", "one", "isomer", "of", "a", "plant", "C1875400#ent", "<e2>", "previously", "known", "as", "5'-methoxyhydnocarpin", "."], "h": {"id": "C1257967", "name": "C1257967#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [18, 19]}}
{"token": ["Ten", "days", "after", "the", "transfusion", "she", "developed", "fever", "and", "C0015230#ent", "<e1>", ",", "with", "subsequent", "hepatic", "and", "intestinal", "disease", "a", "profound", "C1368107#ent", "<e2>"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1368107", "name": "C1368107#ent", "pos": [20, 21]}}
{"token": ["Homogenates", "of", "Crithidia", "fasciculata", "a", "species", "of", "Trypanosomidae", ")", "were", "shown", "to", "contain", "a", "phosphatase", "(", "C2002111#ent", "<e1>", "and", "a", "phosphodiesterase", "(", "EC", "3.1.4.11", ")", "which", "hydrolyse", "C0089795#ent", "<e2>", "."], "h": {"id": "C2002111", "name": "C2002111#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0089795", "name": "C0089795#ent", "pos": [27, 28]}}
{"token": ["In", "conclusion", ",", "elderly", "patients", "have", "a", "greater", "frequency", "of", "C1623038#ent", "<e1>", "at", "presentation", "and", "C1710302#ent", "<e2>", "patients", "<", "or", "=", "30", "years", ",", "and", "they", "have", "a", "lower", "occurrence", "of", "treatment", "failure"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1710302", "name": "C1710302#ent", "pos": [15, 16]}}
{"token": ["The", "syndrome", "of", "C1851920#ent", "<e1>", "a", "minority", "of", "patients", "with", "C0013421#ent", "<e2>", ",", "yet", "it", "is", "of", "considerable", "diagnostic", "importance", "because", "patients", "respond", "dramatically", "to", "L-dopa", "therapy", "."], "h": {"id": "C1851920", "name": "C1851920#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013421", "name": "C0013421#ent", "pos": [10, 11]}}
{"token": ["Dopa-responsive", "dystonia", "C1851920#ent", "<e1>", ")", "may", "cause", "early-onset", "C0013421#ent", "<e2>", ",", "with", "extrapyramidal", "or", "pyramidal", "tract", "dysfunction"], "h": {"id": "C1851920", "name": "C1851920#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013421", "name": "C0013421#ent", "pos": [8, 9]}}
{"token": ["An", "autopsy", "showed", "lesions", "in", "leptomeningeal", "and", "cortical", "arteries", "are", "characteristic", "of", "C1423571#ent", "<e1>", "in", "addition", "to", "anatomicopathological", "changes", "of", "C0078939#ent", "<e2>", "s", "disease", "that", "were", "mostly", "seen", "in", "entorhinal", "cortex", "hippocampus", "."], "h": {"id": "C1423571", "name": "C1423571#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [20, 21]}}
{"token": ["We", "describe", "a", "novel", "LPS", "activated", "signaling", "pathway", "human", "PBMC", "that", "leads", "to", "C1333196#ent", "<e1>", "production", "and", "is", "mediated", "by", "PI3", "kinase", "C0525678#ent", "<e2>", "and", "the", "MEK/ERK", "cassette", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [22, 23]}}
{"token": ["The", "specificity", "of", "IFN-gamma", "induction", "was", "demonstrated", "when", "antibodies", "against", "this", "C1333196#ent", "<e1>", "completely", "suppressed", "the", "overinduction", "of", "C0525678#ent", "<e2>", "mRNAs", "and", ",", "in", "perfect", "correlation", ",", "the", "biological", "effects", "above", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [18, 19]}}
{"token": ["On", "the", "afternoon", "of", "postnatal", "day", "29", ",", "all", "animals", "were", "anesthetized", "and", "perfused", "for", "localization", "of", "C0087140#ent", "<e1>", "and", "LHRH", ",", "C1418963#ent", "<e2>", "alone", ",", "or", "C0087140#ent", "<e1>", "and", "C1418963#ent", "<e2>", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418963", "name": "C1418963#ent", "pos": [22, 23]}}
{"token": ["The", "purpose", "of", "this", "experiment", "was", "to", "determine", "if", "a", "progestin", "antagonist", "decreases", "C0087140#ent", "<e1>", "expression", "specifically", "in", "cells", "that", "also", "express", "C1418963#ent", "<e2>", "in", "the", "preoptic", "area", "ventromedial", "hypothalamus"], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418963", "name": "C1418963#ent", "pos": [22, 23]}}
{"token": ["Two", "patients", "taking", "C0025677#ent", "<e1>", "and", "7", "taking", "C1415335#ent", "<e2>", "were", "withdrawn", "before", "26", "weeks", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415335", "name": "C1415335#ent", "pos": [8, 9]}}
{"token": ["C3273507#ent", "<e1>", "and", "Hsp70", "are", "critical", "for", "the", "precise", "regulation", "of", "C1415470#ent", "<e2>", "activity", "by", "heme", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415470", "name": "C1415470#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "we", "show", "that", "many", "C3273507#ent", "<e1>", "mutants", "exert", "differential", "effects", "on", "C1415470#ent", "<e2>", "and", "steroid", "receptors"], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415470", "name": "C1415470#ent", "pos": [13, 14]}}
{"token": ["The", "response", "to", "a", "C0304516#ent", "<e1>", "alprenolol", ",", "and", "an", "alkyl", "nitrate", "derivative", ",", "C0070277#ent", "<e2>", "PETRIN", ")", "was", "studied", "by", "the", "two", "methods", "after", "double-blind", "administration", "the", "drugs", "."], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0070277", "name": "C0070277#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "both", "PDBu", "(", "10", "nM-1", "microM", ")", "and", "C0256103#ent", "<e1>", "(", "100", "pM-100", "nM", ")", "on", "action", "potential", "C0720099#ent", "<e2>", "were", "dose-dependent", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [21, 22]}}
{"token": ["When", "the", "neurons", "were", "depolarized", "to", "membrane", "potentials", "negative", "than", "-50", "mV", ",", "PDBu", "and", "C0256103#ent", "<e1>", "reduced", "action", "potential", "C0720099#ent", "<e2>", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [20, 21]}}
{"token": ["Of", "these", ",", "18", "cases", "were", "treated", "with", "C3536754#ent", "<e1>", "PPI", ")", ",", "another", "cases", "were", "treated", "with", "histamine", "H2", "receptor", "antagonist", "C1519837#ent", "<e2>"], "h": {"id": "C3536754", "name": "C3536754#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1519837", "name": "C1519837#ent", "pos": [22, 23]}}
{"token": ["At", "the", "doses", "studied", ",", "C0136123#ent", "<e1>", "was", "more", "effective", "than", "captopril", "in", "lowering", "C1413924#ent", "<e2>", ",", "either", "as", "monotherapy", "or", "in", "combination", "with", "a", "diuretic.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0136123", "name": "C0136123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413924", "name": "C1413924#ent", "pos": [14, 15]}}
{"token": ["As", "in", "the", "classical", "pathway", "BCR-induced", "ERK", "activation", "in", "the", "new", ",", "PI3K-independent", "pathway", "required", "C0752313#ent", "<e1>", "and", "was", "reflected", "in", "C0812215#ent", "<e2>", "."], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [15, 16]}, "relation": "exhibits", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [21, 22]}}
{"token": ["The", "Raf", "kinase", "inhibitory", "protein", "RKIP", ")", "binds", "to", "C0812215#ent", "<e1>", "interfering", "with", "binding", "of", "the", "C0752313#ent", "<e2>", "substrate", "and", "potentially", "also", "C0812215#ent", "<e1>", "activation", "."], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [16, 17]}, "relation": "exhibits", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [9, 10]}}
{"token": ["These", "results", "demonstrated", "the", "essential", "role", "of", "Ras-induced", "conformational", "change", "C0752313#ent", "<e1>", "activation", "by", "C0812215#ent", "<e2>", "."], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [10, 11]}, "relation": "exhibits", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [14, 15]}}
{"token": ["We", "also", "isolated", "inactive", "proPLA(2", ")", ",", "having", "C1709708#ent", "<e1>", "preceding", "the", "mature", "C0027203#ent", "<e2>", "from", "the", "gill", "extract"], "h": {"id": "C1709708", "name": "C1709708#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}}
{"token": ["The", "LIP", "cDNA", "encodes", "a", "putative", "preprolipase", "consisting", "of", "a", "26-amino-acid(aa", ")", "signal", "sequence", ",", "a", "97-aa", "C1709708#ent", "<e1>", ",", "and", "a", "269-aa", "mature", "C0027203#ent", "<e2>", "."], "h": {"id": "C1709708", "name": "C1709708#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [24, 25]}}
{"token": ["C1332712#ent", "<e1>", "can", "function", "as", "an", "C1332871#ent", "<e2>", "mediates", "leukocyte", "rolling", "hyaluronan", "(", "HA", ")", "."], "h": {"id": "C1332712", "name": "C1332712#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332871", "name": "C1332871#ent", "pos": [6, 7]}}
{"token": ["C1332712#ent", "<e1>", "is", "a", "widely", "expressed", "integral", "membrane", "glycoprotein", "serves", "as", "a", "specific", "C1332871#ent", "<e2>", "the", "extracellular", "matrix", "glycosaminoglycan", "hyaluronan", "."], "h": {"id": "C1332712", "name": "C1332712#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332871", "name": "C1332871#ent", "pos": [13, 14]}}
{"token": ["Variation", "in", "serum", "levels", "of", "C1332712#ent", "<e1>", ",", "which", "acts", "as", "an", "C1332871#ent", "<e2>", "in", "lymphocyte", "migration", "binding", ",", "have", "been", "reported", "in", "some", "malignancies", "."], "h": {"id": "C1332712", "name": "C1332712#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332871", "name": "C1332871#ent", "pos": [12, 13]}}
{"token": ["C0137996#ent", "<e1>", "shown", "to", "be", "effective", "as", "an", "C0003138#ent", "<e2>", ",", "in", "this", "respect", ",", "not", "significantly", "different", "from", "sodium", "bicarbonate"], "h": {"id": "C0137996", "name": "C0137996#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003138", "name": "C0003138#ent", "pos": [8, 9]}}
{"token": ["Simultaneous", "induction", "of", "the", "mRNAs", "for", "the", "mitochondrial", "chaperonins", "C1415782#ent", "<e1>", "and", "HSP10", ",", "in", "various", "regions", "in", "C0007785#ent", "<e2>", "that", "mitochondrial", "stress", "persist", "concomitantly", "with", "cytosolic", "stress", "in", "C0007785#ent", "<e2>"], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [18, 19]}}
{"token": ["Induction", "of", "C1415782#ent", "<e1>", "has", "been", "demonstrated", "in", "C0007785#ent", "<e2>", "models", ",", "possibly", "reflecting", "mitochondrial", "stress"], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [8, 9]}}
{"token": ["We", "previously", "identified", "membrane", "type-1", "matrix", "metalloproteinase", "MT1-MMP", ")", "as", "a", "transcriptional", "target", "of", "HIF-2alpha", "in", "RCC", "cells", "null", "for", "C0019562#ent", "<e1>", "and", "showed", "that", "MT1-MMP", "is", "C3889446#ent", "<e2>", "in", "these", "cells", "."], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [27, 28]}}
{"token": ["Sulfonylureas", "and", "C1257987#ent", "<e1>", "exert", "their", "glucose-lowering", "effect", "differing", "mechanisms", "of", "action", "-", "the", "C3653359#ent", "<e2>", "by", "stimulating", "insulin", "secretion", "whereas", "the", "C1257987#ent", "<e1>", "are", "insulin", "sensitisers"], "h": {"id": "C1257987", "name": "C1257987#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3653359", "name": "C3653359#ent", "pos": [14, 15]}}
{"token": ["No", "double-blind", "studies", "directly", "compared", "the", "activity", "of", "C1257987#ent", "<e1>", "with", "that", "of", "C3653359#ent", "<e2>", "or", "metformin", "."], "h": {"id": "C1257987", "name": "C1257987#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3653359", "name": "C3653359#ent", "pos": [13, 14]}}
{"token": ["This", "may", "be", "accounted", "for", "by", "inadequate", "detection", "of", "C0041323#ent", "<e1>", "among", "aborigines", "and", "by", "low", "contacts", "with", "C3694279#ent", "<e2>", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3694279", "name": "C3694279#ent", "pos": [18, 19]}}
{"token": ["On", "the", "other", "hand", ",", "C0003143#ent", "<e1>", "and", "other", "I(1", ")", "receptor-selective", "imidazolines", "decreased", "C0917964#ent", "<e2>", "cAMP", "level", "in", "the", "cells", "expressing", "I(1)R", ",", "in", "a", "rauwolscine-", "and", "pertussis", "toxin-insensitive", "manner", "."], "h": {"id": "C0003143", "name": "C0003143#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "underscore", "the", "pathogenic", "role", "of", "C1412322#ent", "<e1>", "diabetic", "sensory", "neuropathy", "the", "altered", "cellular", "signaling", "C0030956#ent", "<e2>", "expressions", "in", "DRG", "neurons", "."], "h": {"id": "C1412322", "name": "C1412322#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}}
{"token": ["Actinomycin", "D", "cycloheximide", "prevented", "and", "RU", "38486", ",", "a", "C1334899#ent", "<e1>", "suppressed", "the", "DEX-induced", "increase", "in", "C1705389#ent", "<e2>", "activity", "."], "h": {"id": "C1334899", "name": "C1334899#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705389", "name": "C1705389#ent", "pos": [16, 17]}}
{"token": ["The", "ring", "openings", "1,2-dihydroazete", ",", "C0012315#ent", "<e1>", ",", "and", "1,2-dihydroazocine", "were", "examined", "using", "HF", ",", "C1418676#ent", "<e2>", ",", "and", "B3LYP", "calculations", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418676", "name": "C1418676#ent", "pos": [15, 16]}}
{"token": ["In", "the", "current", "study", ",", "we", "hypothesized", "whether", "ET-1", "and", "a", "C0079429#ent", "<e1>", "encoding", "ET-1", "might", "be", "involved", "in", "airway", "hyperresponsiveness", "C0596123#ent", "<e2>", ")", ",", "which", "is", "a", "major", "feature", "of", "bronchial", "asthma"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0596123", "name": "C0596123#ent", "pos": [21, 22]}}
{"token": ["We", "determined", "the", "crystal", "structure", "a", "bifunctional", "group", "I", "C1419989#ent", "<e1>", "homing", "endonuclease", "termed", "the", "C1122523#ent", "<e2>", "in", "complex", "with", "its", "DNA", "target", "2.6", "A", "resolution", "."], "h": {"id": "C1419989", "name": "C1419989#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1122523", "name": "C1122523#ent", "pos": [15, 16]}}
{"token": ["Limited", "available", "animal", "studies", "support", "the", "C3536993#ent", "<e1>", "potential", "of", "these", "C2347556#ent", "<e2>", "."], "h": {"id": "C3536993", "name": "C3536993#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2347556", "name": "C2347556#ent", "pos": [11, 12]}}
{"token": ["Intramuscular", "levonantradol", "can", "be", "given", "safely", "at", "doses", "up", "to", "3.0", "mg/kg", ",", "with", "toxicity", "and", "C3536993#ent", "<e1>", "efficacy", "similar", "to", "that", "observed", "with", "other", "C2347556#ent", "<e2>", "."], "h": {"id": "C3536993", "name": "C3536993#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2347556", "name": "C2347556#ent", "pos": [25, 26]}}
{"token": ["Diseases", "associated", "with", "C0042847#ent", "<e1>", "present", "a", "variety", "of", "C0027765#ent", "<e2>", "from", "the", "well", "known", "megaloblastic", "anaemia", "haematological", "manifestation"], "h": {"id": "C0042847", "name": "C0042847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [9, 10]}}
{"token": ["C0042847#ent", "<e1>", "infancy", "may", "cause", "failure", "to", "thrive", ",", "severe", "C0027765#ent", "<e2>", "megaloblastic", "pancytopenia"], "h": {"id": "C0042847", "name": "C0042847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [10, 11]}}
{"token": ["The", "enzymic", "properties", "of", "two", "C0008415#ent", "<e1>", "activities", "in", "human", "prostatic", "secretion", "determined", "with", "partially", "dephosphorylated", "C3814454#ent", "<e2>", "and", "lysine-rich", "histones", "as", "acceptor", "protein", "."], "h": {"id": "C0008415", "name": "C0008415#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3814454", "name": "C3814454#ent", "pos": [16, 17]}}
{"token": ["C2987634#ent", "<e1>", "of", "nicotinic", "acetylcholine", "receptors", "as", "nicotine", "and", "C0023556#ent", "<e2>", "stimulate", "egg", "laying", "however", ",", "the", "genetic", "and", "molecular", "basis", "cholinergic", "neurotransmission", "in", "the", "egg-laying", "circuitry", "is", "not", "well", "understood", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023556", "name": "C0023556#ent", "pos": [9, 10]}}
{"token": ["A", "number", "of", "C2987634#ent", "<e1>", ",", "including", "nicotine", "and", "the", "anthelmintics", "m-aminolevamisole", ",", "C0023556#ent", "<e2>", "and", "morantel", ",", "caused", "contractions", "in", "whole", "worms", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023556", "name": "C0023556#ent", "pos": [13, 14]}}
{"token": ["The", "kinetics", "of", "the", "high", "open", "probability", "mode", "are", "almost", "identical", "when", "the", "C2987634#ent", "<e1>", "is", "ACh", "or", "C0023556#ent", "<e2>", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023556", "name": "C0023556#ent", "pos": [18, 19]}}
{"token": ["In", "the", "present", "study", ",", "after", "administration", "of", "multiple", "fixed", "oral", "doses", "the", "accumulation", "of", "the", "active", "moieties", "C0118168#ent", "<e1>", ",", "enalapril", "and", "C0065374#ent", "<e2>", "was", "compared", "in", "patients", "with", "renal", "insufficiency"], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [23, 24]}}
{"token": ["There", "was", "also", "an", "increase", "in", "serum", "creatinine", "1.1", "on", "C0118168#ent", "<e1>", "to", "1.4", "after", "switching", "to", "C0065374#ent", "<e2>", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [17, 18]}}
{"token": ["To", "compare", "the", "serum", "pharmacokinetics", "of", "C0118168#ent", "<e1>", "with", "enalaprilat", "and", "C0065374#ent", "<e2>", "after", "1", "and", "10", "days", "of", "dosing", "with", "fosinopril", ",", "enalapril", "and", "C0065374#ent", "<e2>", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [11, 12]}}
{"token": ["A", "procedure", "was", "developed", "for", "C1875400#ent", "<e1>", "thick", "ascending", "limb", "cells", "either", "the", "outer", "medulla", "the", "C0001614#ent", "<e2>", "rabbit", "kidneys", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [16, 17]}}
{"token": ["Forty", "days", "after", "intracerebral", "inoculation", "with", "scrapie", "C1875400#ent", "<e1>", "Sc237", ",", "we", "recorded", "prolonged", ",", "epileptiform", "discharges", "C0001614#ent", "<e2>", "and", "hippocampus", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [17, 18]}}
{"token": ["It", "indicated", "that", "those", "alpha-keto", "acids", "their", "effects", "by", "providing", "reducing", "equivalents", "to", "the", "glycine", "cleavage", "system", "possibly", "through", "C1414063#ent", "<e1>", "a", "component", "shared", "by", "the", "glycine", "cleavage", "system", "C0022626#ent", "<e2>"], "h": {"id": "C1414063", "name": "C1414063#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022626", "name": "C0022626#ent", "pos": [29, 30]}}
{"token": ["We", "have", "identified", "two", "mutations", ",", "rot1", "-", "1", "and", "C1415182#ent", "<e1>", "-", "1", ",", "that", "suppress", "the", "loss", "of", "C1825320#ent", "<e2>", "and", "are", "synthetic-lethal", "."], "h": {"id": "C1415182", "name": "C1415182#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1825320", "name": "C1825320#ent", "pos": [20, 21]}}
{"token": ["Twenty-seven", "patients", "with", "inoperable", "or", "recurrent", "primary", "malignant", "brain", "tumors", "previous", "resection", "and/or", "radiotherapy", ",", "were", "treated", "with", "C3540726#ent", "<e1>", "and", "a", "combination", "chemotherapy", "of", "VM", "26", "and", "C0687700#ent", "<e2>", "."], "h": {"id": "C3540726", "name": "C3540726#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0687700", "name": "C0687700#ent", "pos": [28, 29]}}
{"token": ["NXY-059", "produced", "almost", "twice", "the", "degree", "of", "C0242912#ent", "<e1>", "than", "that", "seen", "following", "clomethiazole", "or", "C0383172#ent", "<e2>", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0383172", "name": "C0383172#ent", "pos": [15, 16]}}
{"token": ["Strain", "HAAP-1", "degraded", "29.0", "microM", "C1419330#ent", "<e1>", "in", "<", "14", "days", "and", "formed", "13.0", "mM", "C0000975#ent", "<e2>", "when", "grown", "in", "a", "mineral", "medium", "an", "H2-CO2", "headspace", "."], "h": {"id": "C1419330", "name": "C1419330#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [15, 16]}}
{"token": ["Like", "the", "C1366757#ent", "<e1>", "cells", "from", "C0009207#ent", "<e2>", "patients", "are", "defective", "in", "TCR", "."], "h": {"id": "C1366757", "name": "C1366757#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [6, 7]}}
{"token": ["AMs", "harvested", "from", "the", "BALF", "of", "Sprague-Dawley", "(", "SD", ")", "rat", "were", "treated", "with", "concentrations", "of", "C1334084#ent", "<e1>", "both", "simultaneously", "and", "after", "C2697656#ent", "<e2>", "stimulation", "."], "h": {"id": "C1334084", "name": "C1334084#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [22, 23]}}
{"token": ["Pargyline", "and", "C0048683#ent", "<e1>", ",", "the", "monoamine", "oxidase", "type", "B", "inhibitors", "mimicked", "the", "depressant", "effect", "of", "C0036579#ent", "<e2>", "on", "the", "EPSP", "."], "h": {"id": "C0048683", "name": "C0048683#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036579", "name": "C0036579#ent", "pos": [16, 17]}}
{"token": ["Thyroid", "tissue", "18", "consecutive", "cases", "of", "Hashimoto's", "thyroiditis", "treated", "surgically", "were", "stained", "immunohistochemically", "for", "neurone", "specific", "enolase", "(", "C1880473#ent", "<e1>", ")", ",", "somatostatin", ",", "calcitonin", "and", "C1420709#ent", "<e2>", "."], "h": {"id": "C1880473", "name": "C1880473#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [26, 27]}}
{"token": ["Pancreatic", "secretory", "PLA2", "C1706169#ent", "<e1>", ")", ",", "via", "its", "receptor", "(", "C3889278#ent", "<e2>", ")", ",", "transcriptionally", "activates", "COX-2", "gene", "in", "several", "cell", "types", "although", "a", "specific", "transcription", "factor", "COX-2", "expression", "has", "not", "yet", "been", "identified", "."], "h": {"id": "C1706169", "name": "C1706169#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889278", "name": "C3889278#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "led", "us", "to", "study", "the", "action", "of", "a", "C3536851#ent", "<e1>", "isradipine", ",", "in", "the", "prevention", "of", "non-complicated", "C4284022#ent", "<e2>", "."], "h": {"id": "C3536851", "name": "C3536851#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4284022", "name": "C4284022#ent", "pos": [19, 20]}}
{"token": ["Glutamate", "induced", "phosphorylation", "at", "Thr-558", "of", "C0128818#ent", "<e1>", "was", "still", "detectible", "upon", "chelation", "of", "C0001477#ent", "<e2>", "suggesting", "involvement", "of", "AMPA", "receptor", "of", "N-methyl", "D-Aspartate", "NMDA", ")", "receptor", "in", "this", "phosphorylation", "of", "C0128818#ent", "<e1>", "."], "h": {"id": "C0128818", "name": "C0128818#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [14, 15]}}
{"token": ["The", "phosphorylated", "levels", "of", "C2826592#ent", "<e1>", "phosphatidylinositol", "3-kinase-protein", "B", "Akt", ")", "and", "C0600388#ent", "<e2>", "ERKs", ")", "were", "very", "low", "after", "lethal", "ischaemia", "and", "increased", "following", "reperfusion", "."], "h": {"id": "C2826592", "name": "C2826592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [12, 13]}}
{"token": ["C0052429#ent", "<e1>", "is", "effective", "against", "C0024535#ent", "<e2>", "malaria", "but", "associated", "with", "high", "recrudescence", "rate", "."], "h": {"id": "C0052429", "name": "C0052429#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [5, 6]}}
{"token": ["Quinine", "and", "the", "artemisinin-derivative", "drugs", "artesunate", "and", "C0052429#ent", "<e1>", "are", "effective", "treatments", "for", "severe", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0052429", "name": "C0052429#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [14, 15]}}
{"token": ["These", "results", "confirm", "the", "clinical", "usefulness", "of", "the", "current", "C0040379#ent", "<e1>", "preparation", "in", "the", "treatment", "of", "patients", "with", "C0040259#ent", "<e2>", "probably", "other", "clinical", "forms", "dermatophytoses", "."], "h": {"id": "C0040379", "name": "C0040379#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [18, 19]}}
{"token": ["C0149778#ent", "<e1>", "osteomyelitis", ",", "septic", "arthritis", "and", "C0038012#ent", "<e2>", "were", "studied", "."], "h": {"id": "C0149778", "name": "C0149778#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038012", "name": "C0038012#ent", "pos": [7, 8]}}
{"token": ["C1706017#ent", "<e1>", "and", "BMPR-II", "were", "strongly", "expressed", "in", "both", "normal", "and", "C0949690#ent", "<e2>", "articular", "cartilage"], "h": {"id": "C1706017", "name": "C1706017#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [11, 12]}}
{"token": ["There", "is", "limited", "analgesic", "effectiveness", "controlled", "studies", "serotonin", "reuptake", "inhibitors", "of", "sodium", "channel", "blockers", "C0023660#ent", "<e1>", ",", "tetracaine", ")", ",", "of", "the", "C2936799#ent", "<e2>", "one", "study", ")", "and", "of", "the", "NMDA-receptor", "antagonist", "ketamine", "(", "one", "study", ")", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2936799", "name": "C2936799#ent", "pos": [22, 23]}}
{"token": ["Microinjection", "of", "a", "local", "anesthetic", "C0023660#ent", "<e1>", ")", "or", "a", "C2936799#ent", "<e2>", "THIP", ")", "via", "a", "cannula", "placed", "into", "DNLL", "reversibly", "blocked", "acoustically-evoked", "binaural", "inhibition", "and", "increased", "spontaneous", "firing", "most", "contralateral", "ICc", "neurons", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936799", "name": "C2936799#ent", "pos": [10, 11]}}
{"token": ["C0771311#ent", "<e1>", "not", "been", "compared", "with", "C0086268#ent", "<e2>", ",", "but", ",", "in", "our", "opinion", ",", "it", "has", "better", "evidence", "for", "its", "efficacy", "."], "h": {"id": "C0771311", "name": "C0771311#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086268", "name": "C0086268#ent", "pos": [6, 7]}}
{"token": ["The", "C0771311#ent", "<e1>", "ABP", ")", ",", "3-amino-1,1-hydroxypropane-1,1-diphosphonic", "acid", "APD", ")", ",", "and", "C0086268#ent", "<e2>", "EHDP", ")", "were", "compared", "for", "their", "ability", "to", "inhibit", "the", "osteoclastic", "resorption", "bone", "in", "culture", "."], "h": {"id": "C0771311", "name": "C0771311#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086268", "name": "C0086268#ent", "pos": [12, 13]}}
{"token": ["Inhibitors", "of", "PI", "3-kinase", "the", "mammalian", "target", "of", "rapamycin", "(", "C1307407#ent", "<e1>", ")", "fully", "blocked", "p70", "S6", "kinase", "activation", "implying", "that", "this", "C0031727#ent", "<e2>", "is", "controlled", "by", "PI", "3-kinase", "C1307407#ent", "<e1>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1307407", "name": "C1307407#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "and", "antichaotropic", "salts", "coupled", "with", "a", "prior", "observation", "of", "p66", "monomer-dimer", "equilibrium", "provide", "suggestive", "evidence", "that", "these", "two", "forms", "of", "C0014442#ent", "<e1>", "are", "monomeric", "and", "C1335821#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1335821", "name": "C1335821#ent", "pos": [28, 29]}}
{"token": ["HIV-1", "reverse", "transcriptase", "a", "C0014442#ent", "<e1>", "can", "exist", "in", "both", "homodimeric", "(", "C1335821#ent", "<e2>", ")", "and", "heterodimeric", "(", "p66/p51", ")", "forms", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335821", "name": "C1335821#ent", "pos": [12, 13]}}
{"token": ["CEACAM1", "binding", "triggered", "a", "phosphatidylinositol", "3-kinase-dependent", "activation", "of", "the", "protein", "kinase", "Akt", "without", "influencing", "the", "activity", "of", "C0082529#ent", "<e1>", "ERK", ",", "whereas", "the", "C1519050#ent", "<e2>", "LY294002", "effectively", "blocked", "the", "protective", "effect", "CEACAM1", "."], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1519050", "name": "C1519050#ent", "pos": [23, 24]}}
{"token": ["IGF-I-stimulated", "proliferation", "was", "dependent", "on", "activation", "of", "C0082529#ent", "<e1>", "ERK", ")", "and", "C1519050#ent", "<e2>"], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1519050", "name": "C1519050#ent", "pos": [12, 13]}}
{"token": ["C0040613#ent", "<e1>", "a", "plasminogen", "inhibitor", "for", "the", "treatment", "of", "C0684275#ent", "<e2>", ",", "will", "also", "decrease", "flow", "by", "approximately", "50", "%", "."], "h": {"id": "C0040613", "name": "C0040613#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0684275", "name": "C0684275#ent", "pos": [9, 10]}}
{"token": ["In", "a", "C0034186#ent", "<e1>", "mice", "with", "P.", "aeruginosa", ",", "OPC-17116", "was", "as", "active", "as", "C0008809#ent", "<e2>", "and", "more", "active", "than", "ofloxacin", ",", "enoxacin", ",", "and", "tosufloxacin", "."], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "murine", "model", "of", "C0034186#ent", "<e1>", ",", "levofloxacin", "was", "superior", "to", "C0008809#ent", "<e2>", "in", "preventing", "C0034186#ent", "<e1>", "and", "eradicating", "S.", "aureus"], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [13, 14]}}
{"token": ["C2986618#ent", "<e1>", "was", "found", "mainly", "at", "the", "cell", "surface", "cells", "expressing", "C0086647#ent", "<e2>"], "h": {"id": "C2986618", "name": "C2986618#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086647", "name": "C0086647#ent", "pos": [11, 12]}}
{"token": ["It", "is", "imperative", "to", "establish", "the", "most", "appropriate", "regimen", "with", "C0033126#ent", "<e1>", "for", "the", "curative", "treatment", "vivax", "C0024530#ent", "<e2>", "contracted", "in", "the", "areas", "mentioned", "above", "."], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [17, 18]}}
{"token": ["C0033126#ent", "<e1>", "is", "now", "the", "only", "drug", "available", "to", "eradicate", "Plasmodium", "vivax", "C0024530#ent", "<e2>", "."], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [12, 13]}}
{"token": ["The", "purpose", "of", "these", "studies", "was", "to", "determine", "the", "changes", "in", "Pgp", "and", "C1176140#ent", "<e1>", "expression", "and", "HIV", "PI", "plasma", "exposure", "after", "multiple", "doses", "HIV", "C1413284#ent", "<e2>", "."], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413284", "name": "C1413284#ent", "pos": [25, 26]}}
{"token": ["C0011849#ent", "<e1>", "caused", "an", "increase", "in", "vascular", "antioxidant", "enzyme", "activity", ",", "C1413138#ent", "<e2>", ",", "indicating", "existence", "of", "excess", "hydrogen", "peroxide", "H2O2", ")", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [11, 12]}}
{"token": ["Plasma", "superoxide", "dismutase", "significantly", "reduced", "in", "C0011849#ent", "<e1>", "(", "P", "<", "0.01", ")", ";", "smaller", "decreases", "in", "C1413138#ent", "<e2>", "glutathione", "levels", "were", "observed", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [17, 18]}}
{"token": ["Other", "studies", "suggest", "that", "the", "presence", "of", "cataract", "is", "associated", "with", "altered", "expression", "of", "specific", "C1417679#ent", "<e1>", "including", "metallothionein", "IIa", "osteonectin", ",", "transglutaminase", "2", "C1336623#ent", "<e2>", ",", "multiple", "ribosomal", "proteins", ",", "ADAM9", ",", "and", "protein", "phosphatase", "2A"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1336623", "name": "C1336623#ent", "pos": [24, 25]}}
{"token": ["The", "up-regulated", "elements", "included", "C1417679#ent", "<e1>", "encoding", "some", "HLA", "antigens", "complement", "factors", "ribosomal", "proteins", "and", "C1336623#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336623", "name": "C1336623#ent", "pos": [15, 16]}}
{"token": ["C0025842#ent", "<e1>", "and", "methiothepin", ",", "C2936517#ent", "<e2>", "as", "well", "as", "ondansetron", ",", "a", "5-HT3", "receptor", "antagonist", "showed", "an", "intrinsic", "effect", "ACh", "release", ",", "their", "effects", "being", "additive", "to", "that", "of", "SKF", "38393", "."], "h": {"id": "C0025842", "name": "C0025842#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936517", "name": "C2936517#ent", "pos": [5, 6]}}
{"token": ["The", "serotonin-induced", "response", "was", "blocked", "most", "effectively", "by", "ketanserin", "and", "C0025842#ent", "<e1>", "but", "not", "by", "5-HT3", "or", "C2936517#ent", "<e2>"], "h": {"id": "C0025842", "name": "C0025842#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2936517", "name": "C2936517#ent", "pos": [17, 18]}}
{"token": ["A", "C2987364#ent", "<e1>", "poplar", "hybrid", "and", "two", "transgenic", "clones", "overexpressing", "a", "bacterial", "C0017037#ent", "<e2>", "the", "cytosol", "or", "in", "the", "chloroplasts", "were", "exposed", "to", "chloroacetanilide", "herbicides", "acetochlor", "and", "metolachlor", "dispersed", "in", "the", "soil", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017037", "name": "C0017037#ent", "pos": [12, 13]}}
{"token": ["The", "order", "of", "the", "relative", "activity", "these", "agents", "on", "the", "tracheobronchial", "smooth", "muscles", "TBSM", ")", "was", "C0006945#ent", "<e1>", ">", "5-HT", ">", "histamine", ";", "PGF(2alpha", ")", "and", "C1537501#ent", "<e2>", "were", "inactive", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [26, 27]}}
{"token": ["The", "effect", "of", "tumour", "necrosis", "factor-alpha", "TNF", "alpha", "on", "the", "increase", "in", "cytosolic", "free", "calcium", "induced", "by", "C0006945#ent", "<e1>", "and", "bradykinin", "(", "C1537501#ent", "<e2>", ")", "was", "investigated", "in", "human", "tracheal", "smooth", "muscle", "cells", "culture", "(", "TSMC", ")", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [22, 23]}}
{"token": ["No", "significant", "vascular", "dilation", "identified", "for", "vehicle", "alone", ",", "C0006945#ent", "<e1>", ",", "histamine", ",", "isoproterenol", "hydrochloride", "or", "C1537501#ent", "<e2>", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "salbutamol", ",", "a", "selective", "beta", "2-adrenergic", "agonist", "ipratropium", "bromide", "C3537004#ent", "<e1>", "creatine", "kinase", "CK", ")", "and", "C0010288#ent", "<e2>", "CK-MB", ")", "activity", "in", "serum", "of", "20", "asthmatic", "patients", "was", "investigated", "."], "h": {"id": "C3537004", "name": "C3537004#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010288", "name": "C0010288#ent", "pos": [19, 20]}}
{"token": ["An", "extracellular", "matrix", "metalloproteinase", "inducer", "(EMMPRIN)/", "C1618608#ent", "<e1>", "MT1-MMP", ")", "system", "which", "induces", "and", "activates", "C3494976#ent", "<e2>", ",", "is", "suggested", "to", "be", "functional", "and", "were", "upregulated", "in", "the", "failing", "myocardium", "."], "h": {"id": "C1618608", "name": "C1618608#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [15, 16]}}
{"token": ["The", "C1618608#ent", "<e1>", "C3494976#ent", "<e2>", ")", "constitute", "a", "distinctive", "group", "of", "membrane-bound", "C3494976#ent", "<e2>", "that", "are", "central", "mediators", "surface", "proteolytic", "events", "regulate", "tumor", "cell", "motility", "metastasis", "and", "angiogenesis", "."], "h": {"id": "C1618608", "name": "C1618608#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [3, 4]}}
{"token": ["The", "quickly", "reacting", "proteins", "of", "human", "cells", "proteinkinases", "from", "the", "family", "of", "phophatidylinositol-3-kinase", "related", "proteinkinases", ":", "ataxia-teleangiectasia", "mutated", "ATM", ")", ",", "C1705728#ent", "<e1>", "ATR", ")", "and", "catalytic", "subunit", "DNA-dependant", "proteinkinase", "C1705560#ent", "<e2>", ")", "."], "h": {"id": "C1705728", "name": "C1705728#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705560", "name": "C1705560#ent", "pos": [30, 31]}}
{"token": ["Specific", "inhibition", "of", "EGFR", "function", "by", "either", "the", "selective", "tyrphostin", "C0528985#ent", "<e1>", "or", "a", "dominant-negative", "EGFR", "mutant", "suppressed", "C0170168#ent", "<e2>", "activation", "and", "strongly", "inhibited", "induction", "of", "fos", "gene", "expression", "and", "DNA", "synthesis"], "h": {"id": "C0528985", "name": "C0528985#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [18, 19]}}
{"token": ["C0083183#ent", "<e1>", "and", "phlorizin", "hydrolase", "activities", "showed", "C1420295#ent", "<e2>", "developmental", "patterns"], "h": {"id": "C0083183", "name": "C0083183#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [7, 8]}}
{"token": ["However", ",", "certain", "alpha-linked", "acidic", "dipeptides", "structurally", "similar", "to", "C0067685#ent", "<e1>", ",", "as", "well", "as", "the", "potent", "C0080074#ent", "<e2>", "inhibited", "synaptosomal", "transport", "of", "[3H]NAAG", "but", "were", "ineffective", "as", "inhibitors", "of", "[3H]glutamate", "transport"], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0080074", "name": "C0080074#ent", "pos": [17, 18]}}
{"token": ["To", "identify", "C0086376#ent", "<e1>", "that", "negatively", "affect", "toxT", "transcription", "we", "screened", "C1257902#ent", "<e2>", "V.", "cholerae", "a", "chromosomally", "integrated", "toxT::lacZ", "reporter", "construct", "darker", "blue", "colonies", "on", "media", "containing", "5-bromo-4-chlor-3-indolyl", "beta-D", "galactoside", "X-gal", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1257902", "name": "C1257902#ent", "pos": [11, 12]}}
{"token": ["Synaptic", "complexes", "prokaryotic", "transposons", "when", "transposase", "monomers", "bind", "to", "each", "of", "two", "specific", "end-binding", "sequences", "and", "then", "associate", "to", "bring", "the", "C0086376#ent", "<e1>", "and", "the", "two", "ends", "of", "the", "C1257902#ent", "<e2>", "together", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1257902", "name": "C1257902#ent", "pos": [29, 30]}}
{"token": ["Treatment", "of", "transgenic", "animals", "the", "C3536819#ent", "<e1>", "desipramine", "increased", "C1334899#ent", "<e2>", "mRNA", "concentration", "and", "dexamethasone-binding", "activity", "while", "decreasing", "plasma", "adrenocorticotropin", "hormone", "concentration", "and", "corticosterone", "levels", "."], "h": {"id": "C3536819", "name": "C3536819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [9, 10]}}
{"token": ["5'-[p-(Fluorosulfonyl)benzoyl]adenosine", "(", "FSO2BzAdo", ")", ",", "an", "inhibitor", "of", "C0031727#ent", "<e1>", "and", "ATPases", ",", "inhibits", "C1384522#ent", "<e2>", "to", "pseudo-first-order", "kinetics", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1384522", "name": "C1384522#ent", "pos": [14, 15]}}
{"token": ["The", "first", "peak", "contained", "C0002272#ent", "<e1>", "=", "isomaltase", ")", "and", "maltase", "Ib", "=", "C0053409#ent", "<e2>", ")", "."], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0053409", "name": "C0053409#ent", "pos": [13, 14]}}
{"token": ["This", "gene", "appears", "to", "act", "specifically", "since", "it", "increased", "the", "secretion", "of", "C0002272#ent", "<e1>", "but", "not", "of", "other", "secreted", "enzymes", "like", "acid", "phosphatase", "C0053409#ent", "<e2>", "."], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0053409", "name": "C0053409#ent", "pos": [23, 24]}}
{"token": ["They", "were", "treated", "with", "induction", "therapy", "of", "a", "multipeptide", "derivative", "of", "C0025444#ent", "<e1>", ",", "Peptichemio", ",", "given", "intravenously", ",", "combined", "with", "C0042679#ent", "<e2>", "and/or", "prednisone", ",", "followed", "by", "conventional", "melphalan-prednisone", "therapy"], "h": {"id": "C0025444", "name": "C0025444#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [21, 22]}}
{"token": ["Seven", "polymorphic", "sites", "the", "C2827561#ent", "<e1>", "analyzed", "from", "a", "sample", "of", "43", "non-related", "C0005283#ent", "<e2>", "heterozygotes", "and", "of", "47", "nonrelated", "healthy", "individuals", ",", "from", "Central", "Corsica", "(", "Corte", ")", "."], "h": {"id": "C2827561", "name": "C2827561#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [13, 14]}}
{"token": ["Complete", "lack", "of", "in", "vitro", "C2827561#ent", "<e1>", "the", "fetus", "to", "have", "homozygous", "C0005283#ent", "<e2>", "."], "h": {"id": "C2827561", "name": "C2827561#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [12, 13]}}
{"token": ["Direct", "sequencing", "the", "C2827561#ent", "<e1>", "only", "the", "hemoglobin", "S", "in", "patient", "1", "the", "C0005283#ent", "<e2>", "110", "in", "patient", "2"], "h": {"id": "C2827561", "name": "C2827561#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [13, 14]}}
{"token": ["The", "DED", "in", "C1825027#ent", "<e1>", "is", "sufficient", "for", "its", "DNA", "binding", "C1705064#ent", "<e2>", "activating", "and", "Pol", "I", "transcriptional", "repressor", "activity"], "h": {"id": "C1825027", "name": "C1825027#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705064", "name": "C1705064#ent", "pos": [11, 12]}}
{"token": ["In", "patients", "with", "C0010054#ent", "<e1>", "amiodarone", "and", "C0037707#ent", "<e2>", "are", "similar", "in", "efficacy", "in", "the", "treatment", "of", "VT", "as", "assessed", "by", "electropharmacologic", "testing", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037707", "name": "C0037707#ent", "pos": [7, 8]}}
{"token": ["The", "expression", "of", "cyclooxygenase", "2", "C1705323#ent", "<e1>", ")", "in", "the", "late", "thick", "ascending", "C0030196#ent", "<e2>", ",", "including", "the", "macula", "densa", ",", "is", "found", "to", "be", "upregulated", "in", "an", "activated", "renin-angiotensin", "system"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [13, 14]}}
{"token": ["C1705323#ent", "<e1>", "expression", "was", "also", "found", "in", "the", "cortical", "thick", "ascending", "C0030196#ent", "<e2>", "of", "the", "loop", "of", "Henle", "medullary", "rays", "macula", "densa", "in", "50", "of", "53", "cases", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [11, 12]}}
{"token": ["Light", "and", "electron", "immunocytochemistry", "COX-2", "antibodies", "that", "strong", "C1705323#ent", "<e1>", "immunoreactivity", "was", "localized", "to", "certain", "cortical", "cells", "the", "thick", "ascending", "C0030196#ent", "<e2>", "of", "Henle", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [20, 21]}}
{"token": ["Children", "ultimately", "diagnosed", "with", "C0272286#ent", "<e1>", "often", "referred", "to", "pediatric", "hematology", "clinics", "a", "provisional", "diagnosis", "C0398650#ent", "<e2>", "AITP", ")", "."], "h": {"id": "C0272286", "name": "C0272286#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0398650", "name": "C0398650#ent", "pos": [15, 16]}}
{"token": ["One", "hundred", "and", "fifty-five", "C0149931#ent", "<e1>", "patients", "were", "randomised", "to", "C0297635#ent", "<e2>", "10", "mg", "(", "53", ")", ",", "ibuprofen", "400", "mg", "(", "52", ")", "and", "placebo", "(", "50", ")", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0297635", "name": "C0297635#ent", "pos": [10, 11]}}
{"token": ["Similar", "pattern", "of", "pain", "exacerbation", "also", "observed", "in", "C0149931#ent", "<e1>", "attacks", "treated", "with", "oral", "formulation", "almotriptan", ",", "eletriptan", ",", "C0297635#ent", "<e2>", ",", "and", "zolmitriptan", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0297635", "name": "C0297635#ent", "pos": [19, 20]}}
{"token": ["The", "Muckle-Wells", "syndrome", "C2698414#ent", "<e1>", ")", "is", "a", "hereditary", "inflammatory", "disorder", "by", "acute", "febrile", "episodes", "comprising", "abdominal", "pain", "C0003864#ent", "<e2>", ",", "and", "urticaria", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [18, 19]}}
{"token": ["This", "was", "due", "to", "an", "C0024003#ent", "<e1>", "of", "the", "initial", "fall", "in", "glomerular", "filtration", "rate", "C0016860#ent", "<e2>", "infusion", "."], "h": {"id": "C0024003", "name": "C0024003#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [15, 16]}}
{"token": ["In", "the", "majority", "of", "the", "C2987154#ent", "<e1>", "cases", "with", "C0023890#ent", "<e2>", "disorder", "was", "unknown", "before", "diagnosis", "of", "the", "tumour", "."], "h": {"id": "C2987154", "name": "C2987154#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [9, 10]}}
{"token": ["The", "C2987154#ent", "<e1>", "was", "coexistent", "with", "C0023890#ent", "<e2>", "86.4", "%", "(", "1416/1639", ")", "."], "h": {"id": "C2987154", "name": "C2987154#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [6, 7]}}
{"token": ["C0018969#ent", "<e1>", "is", "a", "C1540116#ent", "<e2>", "confers", "cytoprotection", ",", "but", "its", "role", "in", "gingiva", "during", "cyclosporin", "A", "CsA", ")", "therapy", "is", "unknown", "."], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1540116", "name": "C1540116#ent", "pos": [4, 5]}}
{"token": ["C0018969#ent", "<e1>", "HO-1", ")", "is", "known", "as", "a", "C1540116#ent", "<e2>", "functions", "as", "an", "antioxidant", "enzyme"], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1540116", "name": "C1540116#ent", "pos": [8, 9]}}
{"token": ["These", "C1426102#ent", "<e1>", "modifications", "induce", "a", "specific", "recruitment", "of", "C1426102#ent", "<e1>", "on", "the", "C0079419#ent", "<e1>", "and", "p21", "promoters", "."], "h": {"id": "C1426102", "name": "C1426102#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079419", "name": "C0079419#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "this", "work", "was", "to", "assess", "whether", "C0268543#ent", "<e1>", "could", "be", "responsible", "for", "the", "alterations", "found", "in", "C0745744#ent", "<e2>"], "h": {"id": "C0268543", "name": "C0268543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0745744", "name": "C0745744#ent", "pos": [19, 20]}}
{"token": ["Changes", "in", "the", "cellular", "content", "C0113519#ent", "<e1>", "(", "DAG", ")", "in", "isolated", "rat", "pancreatic", "acini", "response", "to", "C2987634#ent", "<e2>", "stimulation", "were", "studied", "using", "a", "sensitive", "mass", "assay", "."], "h": {"id": "C0113519", "name": "C0113519#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [17, 18]}}
{"token": ["These", "observations", "suggest", "that", "IL-13", "may", "act", "as", "an", "anti-inflammatory", "cytokine", "regulation", "of", "C1333196#ent", "<e1>", "production", "by", "C1426677#ent", "<e2>", "in", "the", "lung", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1426677", "name": "C1426677#ent", "pos": [17, 18]}}
{"token": ["To", "understand", "the", "role", "of", "C1333196#ent", "<e1>", "released", "from", "alveolar", "macrophage", "C1426677#ent", "<e2>", ")", "in", "lung", "fibrosis", "by", "mineral", "dust"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1426677", "name": "C1426677#ent", "pos": [11, 12]}}
{"token": ["In", "the", "present", "study", ",", "we", "analyzed", "the", "profile", "of", "C1333196#ent", "<e1>", "induced", "respectively", ",", "by", "M-CSF", "and", "GM-CSF", "during", "rat", "C1426677#ent", "<e2>", "differentiation", "using", "reverse", "transcription-PCR"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1426677", "name": "C1426677#ent", "pos": [21, 22]}}
{"token": ["In", "this", "report", "the", "importance", "of", "typhoid", "hepatitis", "its", "clinical", "significance", "the", "diagnosis", "of", "C0041466#ent", "<e1>", "highlighted", ",", "particularly", "at", "places", "where", "viral", "hepatitis", "C0023886#ent", "<e2>", "usually", "common", "and", "C0041466#ent", "<e1>", "endemic", "."], "h": {"id": "C0023886", "name": "C0023886#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0041466", "name": "C0041466#ent", "pos": [14, 15]}}
{"token": ["As", "the", "antimalarial", "effect", "C0055461#ent", "<e1>", "is", "manifested", "by", "C0017547#ent", "<e2>", "autophagosome", "formation", "in", "Plasmodium", ",", "a", "common", "antirheumatic", "and", "antimalarial", "mechanism", "of", "action", "is", "postulated", "."], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [9, 10]}}
{"token": ["There", "was", "no", "correlation", "of", "the", "symptom", "complex", "with", "serum", "potassium", "concentration", ",", "except", "in", "a", "few", "patients", "who", "were", "simultaneously", "receiving", "C0304489#ent", "<e1>", "diuretics", "for", "C0020538#ent", "<e2>", "who", "became", "frankly", "hypokalemic", "."], "h": {"id": "C0304489", "name": "C0304489#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [26, 27]}}
{"token": ["The", "unique", "aspect", "of", "this", "study", "is", "the", "finding", "that", "C0304489#ent", "<e1>", "did", "not", "abolish", "the", "C0020538#ent", "<e2>", "action", "of", "salt", "in", "S", "rats", "."], "h": {"id": "C0304489", "name": "C0304489#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["Sodium", "meclofenamate", "the", "smooth", "muscle-stimulating", "action", "of", "C1705889#ent", "<e1>", ";", "the", "5-HT", "blocking", "agents", "C0078631#ent", "<e2>", "and", "methysergide", "diminished", "the", "contractile", "effects", "5-HT", "."], "h": {"id": "C1705889", "name": "C1705889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0078631", "name": "C0078631#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "aimed", "to", "evaluate", "the", "effect", "of", "L.", "GG-degraded", "bovine", "casein", "on", "T-cell", "activation", "i.e.", "C1522405#ent", "<e1>", "mRNA", "expression", "and", "C1259877#ent", "<e2>", "PKC", ")", "translocation", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [22, 23]}}
{"token": ["Growth", "factors", "as", "platelet", "derived", "C0812325#ent", "<e1>", "PDGF", ")", "have", "been", "postulated", "to", "be", "important", "C0127400#ent", "<e2>", "of", "neointimal", "proliferation", "observed", "in", "atherosclerotic", "plaques", "restenotic", "lesions", "following", "coronary", "interventions"], "h": {"id": "C0812325", "name": "C0812325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [15, 16]}}
{"token": ["Variability", "of", "C1413868#ent", "<e1>", "catalytic", "activities", "in", "human", "liver", "was", "between", "24-fold", "for", "C0066286#ent", "<e2>", "to", "sevenfold", "for", "coumarin", ",", "while", "C1413868#ent", "<e1>", "content", "varied", "68-fold", "in", "human", "liver", "microsomes", "."], "h": {"id": "C1413868", "name": "C1413868#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0066286", "name": "C0066286#ent", "pos": [13, 14]}}
{"token": ["Taken", "together", ",", "these", "results", "clearly", "indicate", "that", ",", "in", "human", "liver", ",", "C1413868#ent", "<e1>", "is", "a", "major", "enzyme", "responsible", "for", "metabolism", "of", "C0066286#ent", "<e2>", ",", "ETBE", ",", "and", "TAME", "."], "h": {"id": "C1413868", "name": "C1413868#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0066286", "name": "C0066286#ent", "pos": [23, 24]}}
{"token": ["1", "The", "pharmacokinetics", ",", "efficacy", "and", "toxicity", "of", "a", "new", "parenteral", "formulation", "C0148859#ent", "<e1>", "evaluated", "in", "12", "adults", "with", "acute", "uncomplicated", "C0024535#ent", "<e2>", "malaria", "and", "nine", "adults", "who", "attended", "in", "convalescence", "."], "h": {"id": "C0148859", "name": "C0148859#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [21, 22]}}
{"token": ["We", "investigated", "the", "compensatory", "changes", "in", "endogenous", "apelin", "and", "C1538915#ent", "<e1>", "levels", "in", "the", "setting", "of", "C0349782#ent", "<e2>"], "h": {"id": "C1538915", "name": "C1538915#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0349782", "name": "C0349782#ent", "pos": [16, 17]}}
{"token": ["Immunohistochemical", "analysis", "that", "during", "embryonic", "life", "sensory", "neurons", "express", "C1705610#ent", "<e1>", "alpha-common", "and", "C1705610#ent", "<e1>", "C1420369#ent", "<e1>", "rather", "than", "C1705610#ent", "<e1>", "alpha-1", "."], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [15, 16]}}
{"token": ["C1257966#ent", "<e1>", "show", "an", "estrogenic", "or", "C0014930#ent", "<e2>", "to", "the", "structural", "similarity", "with", "the", "estrogen", "skeleton", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014930", "name": "C0014930#ent", "pos": [6, 7]}}
{"token": ["The", "growth-inhibitory", "actions", "of", "C1257966#ent", "<e1>", "were", "distinctly", "different", "from", "those", "of", "C0014930#ent", "<e2>", "tamoxifen", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014930", "name": "C0014930#ent", "pos": [12, 13]}}
{"token": ["The", "enzyme", "has", "been", "studied", "extensively", "as", "a", "drug", "target", "bacterial", ",", "protozoal", "and", "C0026946#ent", "<e1>", "and", "also", "for", "neoplastic", "and", "C0004364#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [21, 22]}}
{"token": ["Cultures", "incubated", "with", "chrysotile", "or", "crocidolite", "asbestos", "but", "not", "refractory", "ceramic", "fiber", "1", "RCF-1", ")", ",", "demonstrate", "localized", "cleavage", "of", "C1367553#ent", "<e1>", ",", "which", "was", "inhibited", "by", "C0002502#ent", "<e2>", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [27, 28]}}
{"token": ["We", "also", "demonstrated", "that", "C1539312#ent", "<e1>", "inhibits", "the", "deactivation", "activity", "C0047791#ent", "<e2>", "."], "h": {"id": "C1539312", "name": "C1539312#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0047791", "name": "C0047791#ent", "pos": [10, 11]}}
{"token": ["If", "the", "administration", "of", "C0026056#ent", "<e1>", "can", "not", "be", "avoided", ",", "the", "dose", "of", "C0026056#ent", "<e1>", "should", "be", "reduced", "during", "concomitant", "treatment", "with", "C0282138#ent", "<e1>", "and", "verapamil", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [23, 24]}}
{"token": ["No", "significant", "were", "observed", "in", "C0527353#ent", "<e1>", "pharmacokinetics", "between", "poor", "and", "extensive", "metabolizers", "via", "C3887685#ent", "<e2>", "."], "h": {"id": "C0527353", "name": "C0527353#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [14, 15]}}
{"token": ["The", "lack", "of", "both", "reinforcing", "properties", "and", "discriminative", "stimulus", "properties", "similar", "to", "d-amphetamine", "or", "C0030883#ent", "<e1>", "suggests", "that", "C0643425#ent", "<e2>", "has", "little", "or", "no", "abuse", "potential", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0643425", "name": "C0643425#ent", "pos": [18, 19]}}
{"token": ["Severe", "upper", "airway", "stenosis", "diagnosed", "in", "a", "23", "year", "old", "woman", "who", "presented", "with", "C0019825#ent", "<e1>", ",", "cough", "and", "C0013404#ent", "<e2>", "8", "yrs", "after", "initial", "diagnosis", "of", "ulcerative", "colitis"], "h": {"id": "C0019825", "name": "C0019825#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [19, 20]}}
{"token": ["The", "human", "tissue", "C0022478#ent", "<e1>", "are", "secreted", "serine", "proteases", "encoded", "by", "a", "group", "of", "C1512488#ent", "<e2>", "in", "tandem", "on", "chromosome", "19q13.3", "4", "."], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [14, 15]}}
{"token": ["An", "interesting", "observation", "is", "that", "C0004623#ent", "<e1>", "candida", "vaginitis", "rare", ",", "while", "coinfection", "between", "other", "types", "of", "C0085166#ent", "<e2>", "is", "common", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0085166", "name": "C0085166#ent", "pos": [17, 18]}}
{"token": ["Significant", "differences", "could", "be", "calculated", "between", "the", "two", "groups", "with", "regard", "to", "C0004623#ent", "<e1>", "the", "vagina", "(", "60/22", ")", ",", "C0085166#ent", "<e2>", "54/38", ")", "and", "trichomoniasis", "(", "35/22", ")", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0085166", "name": "C0085166#ent", "pos": [20, 21]}}
{"token": ["Apart", "from", "prothrombin", "and", "FXa", ",", "FEIBA", "contains", "other", "C0086376#ent", "<e1>", "of", "the", "C3541956#ent", "<e2>", "which", "could", "also", "facilitate", "haemostasis", "in", "haemophilia", "patients", "with", "inhibitors", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541956", "name": "C3541956#ent", "pos": [13, 14]}}
{"token": ["These", "two", "cell", "lines", ",", "therefore", ",", "useful", "for", "clarifying", "the", "role", "of", "A", "C0211705#ent", "<e1>", "and", "C", "kinase", "PAI-2", "and", "u-PA", "synthesis", "in", "human", "C0812317#ent", "<e2>"], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812317", "name": "C0812317#ent", "pos": [25, 26]}}
{"token": ["We", "studied", "the", "full", "obstetric", "histories", "of", "8", "women", "with", "C0024141#ent", "<e1>", "who", "had", "taken", "either", "chloroquine", "phosphate", "C0596007#ent", "<e2>", "Plaquenil", ")", "throughout", "the", "entire", "length", "of", "at", "least", "1", "pregnancy", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0596007", "name": "C0596007#ent", "pos": [18, 19]}}
{"token": ["Lychnopholide", "(", "C1425583#ent", "<e1>", ")", ",", "a", "sesquiterpene", "lactone", "antitumor", ",", "trypanocidal", ",", "and", "C1136254#ent", "<e2>", "was", "isolated", "from", "Vanillosmopsis", "erythropappa", "."], "h": {"id": "C1425583", "name": "C1425583#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [14, 15]}}
{"token": ["This", "suggested", "that", "C1413109#ent", "<e1>", "may", "be", "activated", "in", "hydrogen", "peroxide", "treated", "lenses", ",", "since", "C1417326#ent", "<e2>", "a", "known", "C1413109#ent", "<e1>", "substrate", ",", "and", "C1413109#ent", "<e1>", "undergoes", "autolysis", "and", "degradation", "when", "activated", "."], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417326", "name": "C1417326#ent", "pos": [15, 16]}}
{"token": ["C0018784#ent", "<e1>", "rarely", "the", "first", "manifestation", "of", "C0026769#ent", "<e2>", "MS", ")", "."], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [7, 8]}}
{"token": ["Characterized", "by", "the", "clinical", "triad", "encephalopathy", ",", "branch", "retinal", "artery", "occlusions", "and", "C0018784#ent", "<e1>", "patients", "with", "Susac", "syndrome", "often", "misdiagnosed", "with", "multiple", "sclerosis", "C0026769#ent", "<e2>", ")", "."], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [23, 24]}}
{"token": ["Three", "Botrytis-susceptible", "mutants", "bos2", ",", "bos3", ",", "and", "C1704896#ent", "<e1>", "which", "define", "independent", "and", "novel", "C0678933#ent", "<e2>", "for", "Arabidopsis", "resistance", "to", "Botrytis", "cinerea", "isolated", "."], "h": {"id": "C1704896", "name": "C1704896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0678933", "name": "C0678933#ent", "pos": [15, 16]}}
{"token": ["A", "simple", "and", "accurate", "method", "is", "described", "for", "synthesis", "of", "C0000424#ent", "<e1>", "its", "derivative", ",", "C0073853#ent", "<e2>"], "h": {"id": "C0000424", "name": "C0000424#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0073853", "name": "C0073853#ent", "pos": [15, 16]}}
{"token": ["A", "quantitative", "determination", "of", "C0000424#ent", "<e1>", "performed", "after", "its", "conversion", "into", "C0073853#ent", "<e2>", "reacting", "with", "excess", "of", "2-bromoethylamine", "."], "h": {"id": "C0000424", "name": "C0000424#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0073853", "name": "C0073853#ent", "pos": [11, 12]}}
{"token": ["Ellipticine", "(", "0.01", "nM", ")", ",", "a", "known", "inhibitor", "of", "cytochrome", "P450", "metabolism", "aryl", "hydrocarbon", "receptor", "C0596123#ent", "<e1>", ")", "antagonist", ",", "inhibited", "c-Ha-ras", "induction", "by", "C1822725#ent", "<e2>", "(", "3", "microM", ")", "."], "h": {"id": "C0596123", "name": "C0596123#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1822725", "name": "C1822725#ent", "pos": [25, 26]}}
{"token": ["Overexpression", "of", "C/EBPs", "abrogated", "stimulation", "of", "1.6CAT", "by", "CBP", "or", "C0596123#ent", "<e1>", "alone", ",", "or", "in", "combination", ",", "regardless", "of", "C1822725#ent", "<e2>", "treatment", "."], "h": {"id": "C0596123", "name": "C0596123#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1822725", "name": "C1822725#ent", "pos": [20, 21]}}
{"token": ["The", "activation", "of", "C2986464#ent", "<e1>", "was", "examined", "in", "mouse", "macrophages", "treated", "with", "LAMPs", "by", "indirect", "immunofluorescence", "C0281643#ent", "<e2>", ")", ",", "immunocytochemistry", "and", "Western", "blot"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0281643", "name": "C0281643#ent", "pos": [16, 17]}}
{"token": ["The", "immunomodulatory", "oligonucleotide", "potent", "antitumor", "effects", "monotherapy", "and", "in", "combination", "with", "conventional", "C0003392#ent", "<e1>", "and", "may", "act", "directly", "on", "NSCLC", "cells", "C1423633#ent", "<e2>", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423633", "name": "C1423633#ent", "pos": [21, 22]}}
{"token": ["This", "review", "will", "discuss", "the", "ultrasound", "appearances", "of", "a", "variety", "of", "musculoskeletal", "infections", "as", "cellulitis", ",", "C0039520#ent", "<e1>", "pyomyositis", ",", "soft-tissue", "abscesses", ",", "septic", "arthritis", "acute", "and", "C0008707#ent", "<e2>", "and", "post-operative", "infection"], "h": {"id": "C0039520", "name": "C0039520#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008707", "name": "C0008707#ent", "pos": [27, 28]}}
{"token": ["In", "C0020538#ent", "<e1>", "PRA", "was", "higher", "than", "in", "C0085580#ent", "<e2>", "but", "the", "serum", "uric", "acid", "were", "similar", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [8, 9]}}
{"token": ["Identification", "of", "patients", "with", "C0020538#ent", "<e1>", "RVH", ")", "among", "the", "larger", "group", "of", "patients", "with", "C0085580#ent", "<e2>", "been", "aided", "by", "a", "wide", "variety", "of", "in", "vitro", "in", "vivo", "nuclear", "medicine", "procedures"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [15, 16]}}
{"token": ["The", "concentrations", "of", "C0020538#ent", "<e1>", "in", "the", "blood", "of", "patients", "with", "the", "malignant", "phase", "C0085580#ent", "<e2>", "found", "to", "be", "greatly", "increased", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [14, 15]}}
{"token": ["Continued", "studies", "of", "the", "pathogenesis", "of", "acute", "and", "chronic", "parvoviral", "B19", "infections", "C0022408#ent", "<e1>", "may", "provide", "insights", "into", "virus-host", "interactions", "mechanisms", "of", "joint", "disease", "C0009782#ent", "<e2>"], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [24, 25]}}
{"token": ["Their", "etiology", "includes", "not", "only", "mechanical", "forces", "also", "underlying", "C0022408#ent", "<e1>", "such", "as", "Ehlers-Danlos", "syndrome", "type", "IV", "other", "C0009782#ent", "<e2>"], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [18, 19]}}
{"token": ["Although", "asterixis", ",", "C0013421#ent", "<e1>", ",", "and", "tremor", "have", "been", "described", "with", "C0006949#ent", "<e2>", "(", "Tegretol", ")", ",", "there", "is", "no", "report", "of", "orofacial", "dyskinesia"], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006949", "name": "C0006949#ent", "pos": [12, 13]}}
{"token": ["We", "have", "cared", "for", "three", "children", "in", "whom", "four", "episodes", "of", "C0013421#ent", "<e1>", "proceeding", "to", "opisthotonus", "occurred", "in", "association", "with", "C0006949#ent", "<e2>", "use", "."], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006949", "name": "C0006949#ent", "pos": [20, 21]}}
{"token": ["C0058310#ent", "<e1>", "may", "be", "involved", "in", "the", "pathogenesis", "of", "C0031090#ent", "<e2>", "enhancing", "IL-6", "levels", "in", "periodontal", "lesions"], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [9, 10]}}
{"token": ["C0058310#ent", "<e1>", "be", "involved", "in", "the", "pathology", "of", "C0031090#ent", "<e2>", "upregulating", "ICAM-1", "expression", "in", "HGF", "."], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [8, 9]}}
{"token": ["Serum", "IgE", "determined", "in", "four", "groups", "of", "Singapore", "Chinese", "of", "292", "normal", "subjects", "15", "patients", "with", "C0011615#ent", "<e1>", "39", "with", "drug", "allergy", "14", "with", "C0004096#ent", "<e2>"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [16, 17]}, "relation": "has_manifestation", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [24, 25]}}
{"token": ["We", "conclude", "that", "patients", "with", "severe", "C0011615#ent", "<e1>", "mild", "asthma", "at", "risk", "for", "developing", "pronounced", "late", "C0004096#ent", "<e2>", "responses", "after", "allergen", "exposure"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["We", "show", "that", "disruption", "of", "EMT", "is", "associated", "with", "persistence", "of", "platelet", "endothelial", "cell", "adhesion", "molecule-1", "C1706508#ent", "<e1>", ")", "and", "decreased", "C0172537#ent", "<e2>", "MMP-2", ")", "expression", "."], "h": {"id": "C1706508", "name": "C1706508#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [21, 22]}}
{"token": ["Carnosic", "acid", "scavenges", "free", "radicals", "the", "C3179066#ent", "<e1>", ",", "giving", "rise", "to", "C0001975#ent", "<e2>", "mainly", "isorosmanol", "."], "h": {"id": "C3179066", "name": "C3179066#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [12, 13]}}
{"token": ["To", "test", "the", "efficacy", "and", "tolerability", "of", "long-term", "administration", "of", "the", "angiotensin", "converting", "enzyme", "inhibitor", "C0053091#ent", "<e1>", ",", "in", "dogs", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0053091", "name": "C0053091#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "we", "labeled", "methylene", "diphosphonate", "MDP", ")", ",", "C0015121#ent", "<e1>", "HEDP", ")", ",", "and", "C0012544#ent", "<e2>", "HDP", ")", "with", "Re-188", "."], "h": {"id": "C0015121", "name": "C0015121#ent", "pos": [11, 12]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [17, 18]}}
{"token": ["Zoledronate", ",", "C0015121#ent", "<e1>", "a", "new", "C0012544#ent", "<e2>"], "h": {"id": "C0015121", "name": "C0015121#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [6, 7]}}
{"token": ["RNA", "interference", "dominant-negative", "mutant", "expression", "analyses", "that", "neural", "WASP", "(", "N-WASP", ")", ",", "C1412171#ent", "<e1>", "and", "their", "upstream", "regulators", "C1417611#ent", "<e2>", ",", "Cdc42", ",", "and", "WIP", ",", "are", "necessary", "for", "invadopodium", "formation", "."], "h": {"id": "C1412171", "name": "C1412171#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417611", "name": "C1417611#ent", "pos": [19, 20]}}
{"token": ["We", "report", "here", "the", "novel", "finding", "that", "the", "anti-CD9", "monoclonal", "antibodies", "50H.19", "and", "ALB6", "promote", "physical", "association", "CD9", "antigen", "the", "C0040015#ent", "<e1>", "GPIIb-IIIa", ")", "component", "of", "the", "C1416498#ent", "<e2>"], "h": {"id": "C0040015", "name": "C0040015#ent", "pos": [20, 21]}, "relation": "manifestation_of", "t": {"id": "C1416498", "name": "C1416498#ent", "pos": [27, 28]}}
{"token": ["Alternatively", ",", "the", "disruption", "of", "specific", "C1333828#ent", "<e1>", "homologous", "recombination", "be", "used", "to", "eliminate", "competing", "C0085249#ent", "<e2>", "that", "act", "on", "a", "common", "substrate", "."], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [15, 16]}}
{"token": ["Three", "(", "epsGIK", ")", "of", "the", "six", "predicted", "C1333828#ent", "<e1>", "low", "amino", "acid", "similarity", "with", "known", "C0085249#ent", "<e2>", "."], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [16, 17]}}
{"token": ["So", "far", ",", "the", "direct", "cloning", "of", "unknown", "C1333828#ent", "<e1>", "polymerase", "chain", "reaction", "PCR", ")", "has", "not", "been", "described", "because", "C0085249#ent", "<e2>", "do", "not", "share", "strongly", "conserved", "amino", "acid", "regions"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [20, 21]}}
{"token": ["We", "show", "that", "the", "C1516312#ent", "<e1>", "reduces", "cell", "death", "the", "C0002556#ent", "<e2>", "induces", "an", "increased", "amount", "of", "cell", "death", "the", "central", "population", "cells", "."], "h": {"id": "C1516312", "name": "C1516312#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002556", "name": "C0002556#ent", "pos": [10, 11]}}
{"token": ["C2349426#ent", "<e1>", "may", "be", "a", "presentation", "of", "other", "C0018681#ent", "<e2>", "as", "new", "onset", "migraine", ",", "tension", ",", "or", "benign", "thunderclap", "headache", "."], "h": {"id": "C2349426", "name": "C2349426#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [8, 9]}}
{"token": ["It", "is", "suggested", "that", "the", "agenesis", "of", "the", "vermis", "is", "caused", "by", "a", "C0020255#ent", "<e1>", "is", "probably", "the", "case", "in", "the", "C0010964#ent", "<e2>"], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0010964", "name": "C0010964#ent", "pos": [21, 22]}}
{"token": ["Questionnaire", "results", "showed", "that", "workers", "complained", "of", "C0521471#ent", "<e1>", ",", "nasal", "and", "eye", "irritation", "as", "well", "as", "C0010200#ent", "<e2>", "and", "bothersome", "odours", "."], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [17, 18]}}
{"token": ["A", "partially", "purified", "enzyme", "(", "carbocyclase", ")", "from", "the", "flavedo", "of", "Citrus", "limonum", "alpha-pinene", ",", "beta-pinene", ",", "C0064992#ent", "<e1>", ",", "and", "gamma-terpinene", "from", "geranyl", "pyrophosphate", "C0343055#ent", "<e2>", ")", "and", "neryl", "pyrophosphate"], "h": {"id": "C0064992", "name": "C0064992#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0343055", "name": "C0343055#ent", "pos": [25, 26]}}
{"token": ["This", "C0043167#ent", "<e1>", "toxin-insensitive", "action", "of", "carbachol", "was", "antagonized", "by", "atropine", "and", "C0031978#ent", "<e2>", "and", "was", "prevented", "when", "either", "of", "two", "different", "phosphodiesterase", "inhibitors"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [12, 13]}}
{"token": ["We", "suggest", "that", "this", "early", "and", "persistent", "increase", "in", "ubiquitinated", "proteins", "induced", "by", "C1421437#ent", "<e1>", "mutations", "in", "p97/VCP", "may", "ultimately", "lead", "to", "C3714552#ent", "<e2>", "the", "observed", "muscle", "pathology"], "h": {"id": "C1421437", "name": "C1421437#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [22, 23]}}
{"token": ["C0031485#ent", "<e1>", "(", "PKU", ")", "is", "a", "C0025517#ent", "<e2>", "in", "which", "loss", "of", "phenylalanine", "hydroxylase", "activity", "results", "in", "neurotoxic", "levels", "of", "phenylalanine", "."], "h": {"id": "C0031485", "name": "C0031485#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [7, 8]}}
{"token": ["We", "postulate", "that", "telmisartan", ",", "an", "C3536793#ent", "<e1>", "partial", "peroxisome", "proliferators-activated", "receptorgamma", "partial", ",", "may", "improve", "insulin", "resistance", "with", "C0072970#ent", "<e2>", ",", "an", "angiotensin-converting", "enzyme", "inhibitor", "ACEI", ")", "in", "NMHT", "."], "h": {"id": "C3536793", "name": "C3536793#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072970", "name": "C0072970#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "the", "baseline", "level", "of", "C1704467#ent", "<e1>", "was", "enhanced", "by", "TGF-beta1", "and", "reduced", "by", "inhibition", "of", "C1336624#ent", "<e2>", "ALK5", ")", ",", "a", "TGF-beta1", "type", "I", "receptor"], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336624", "name": "C1336624#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", "to", "membrane", "C2986617#ent", "<e1>", "associated", "with", "APN", "enzyme", "activity", "neither", "membrane", "CD10", ",", "nor", "its", "C0014442#ent", "<e2>", "(", "NEP", ")", "activity", "could", "be", "found", "on", "the", "same", "keratinocyte", "samples", "."], "h": {"id": "C2986617", "name": "C2986617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Expression", "of", "the", "cloned", "C2986617#ent", "<e1>", "in", "overproduction", "of", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C2986617", "name": "C2986617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["Increased", "membrane", "C2986617#ent", "<e1>", "expression", "was", "associated", "with", "increase", "of", "its", "C0014442#ent", "<e2>", "(", "APN", ")", "activity", "and", "with", "a", "decrease", "of", "its", "signal", "transduction", "."], "h": {"id": "C2986617", "name": "C2986617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["The", "NCS", "(", "C1414814#ent", "<e1>", "C0086376#ent", "<e2>", "are", "a", "family", "of", "Ca2", "+", "-binding", "C0086376#ent", "<e2>", "with", "diverse", "functions", "."], "h": {"id": "C1414814", "name": "C1414814#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}}
{"token": ["A", "consistent", "synergism", "was", "observed", "between", "all", "concentrations", "of", "C0010592#ent", "<e1>", "used", "and", "C3265062#ent", "<e2>", "10(-8", ")", "and", "10(-7", ")", "M", ")", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3265062", "name": "C3265062#ent", "pos": [13, 14]}}
{"token": ["We", "have", "examined", "the", "transcriptional", "regulation", "the", "Th1-specific", "C1705753#ent", "<e1>", "the", "Th2-specific", "IL-4", "gene", "transient", "transfection", "of", "C0008169#ent", "<e2>", "CAT", ")", "constructs", "into", "T", "cell", "clones", "and", "by", "electrophoretic", "mobility", "shift", "assays"], "h": {"id": "C1705753", "name": "C1705753#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008169", "name": "C0008169#ent", "pos": [17, 18]}}
{"token": ["C0011603#ent", "<e1>", "to", "urinary", "and/or", "C0015732#ent", "<e2>", "a", "common", "problem", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015732", "name": "C0015732#ent", "pos": [5, 6]}}
{"token": ["Mutations", "in", "the", "amyloid", "precursor", "protein", "APP", ")", ",", "presenilin", "1", "PSEN1", ")", "and", "presenilin", "2", "C1418986#ent", "<e1>", ")", "genes", "are", "associated", "with", "early-onset", "C0002395#ent", "<e2>", "EOAD", ")", "."], "h": {"id": "C1418986", "name": "C1418986#ent", "pos": [16, 17]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [24, 25]}}
{"token": ["Post-mortem", "pancreatic", "morphology", "was", "normal", "in", "a", "subject", "with", "the", "C1418986#ent", "<e1>", "variant", "and", "early", "onset", "C0002395#ent", "<e2>"], "h": {"id": "C1418986", "name": "C1418986#ent", "pos": [10, 11]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [16, 17]}}
{"token": ["Mutations", "in", "the", "presenilin", "1", "C1418986#ent", "<e1>", "been", "identified", "that", "cause", "early", "onset", "C0002395#ent", "<e2>"], "h": {"id": "C1418986", "name": "C1418986#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [13, 14]}}
{"token": ["Recently", "obtained", "data", "suggest", "that", "there", "is", "a", "C0275522#ent", "<e1>", "inflammatory", "activity", "the", "apparently", "uninvolved", "intestinal", "mucosa", "C0010346#ent", "<e2>", "CD", ")", "."], "h": {"id": "C0275522", "name": "C0275522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [17, 18]}}
{"token": ["Concentrations", "of", "CXCL10", "and", "C1332816#ent", "<e1>", "in", "the", "CSF", "of", "C0752235#ent", "<e2>", "patients", "were", "significantly", "higher", "compared", "with", "the", "corresponding", "serum", "samples", "."], "h": {"id": "C1332816", "name": "C1332816#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "the", "role", "of", "the", "CXCR3", "chemokine", "CXCL11", "(", "C1332816#ent", "<e1>", ")", "for", "leukocyte", "recruitment", "to", "the", "CSF", "in", "C0752235#ent", "<e2>", "(", "NB", ")", "."], "h": {"id": "C1332816", "name": "C1332816#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [20, 21]}}
{"token": ["Interestingly", ",", "peptide", "sequencing", "that", "the", "N-terminal", "methionine", "lacking", "in", "the", "mature", "C2987364#ent", "<e1>", "enzyme", ",", "presumably", "due", "to", "the", "action", "of", "C0127863#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0127863", "name": "C0127863#ent", "pos": [22, 23]}}
{"token": ["C0037567#ent", "<e1>", "very", "rarely", "responsible", "for", "a", "C0543698#ent", "<e2>", "and", "our", "case", "is", "the", "first", "report", "of", "sodium", "valproate-induced", "cutaneous", "pseudolymphoma", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0543698", "name": "C0543698#ent", "pos": [7, 8]}}
{"token": ["Ionizing", "radiation", "the", "expression", "of", "both", "p53", "and", "C3470429#ent", "<e1>", ",", "and", "in", "cells", "C0669365#ent", "<e2>", "synthesizing", "exogenous", "CDK4", ",", "the", "return", "of", "p53", "protein", "to", "baseline", "is", "prolonged", "."], "h": {"id": "C3470429", "name": "C3470429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}}
{"token": ["C1720860#ent", "<e1>", "Hutchinson-Gilford", "progeria", "syndrome", "laminopathies", "caused", "by", "mutation", "in", "LMNA", "that", "feature", "C0004153#ent", "<e2>", ",", "which", "is", "related", "to", "proatherogenic", "metabolic", "disturbances", "and", "to", "the", "generalized", "process", "accelerated", "aging", ",", "respectively", "."], "h": {"id": "C1720860", "name": "C1720860#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [13, 14]}}
{"token": ["Wolfram", "syndrome", "the", "association", "of", "diabetes", "mellitus", "C0338508#ent", "<e1>", "and", "is", "sometimes", "called", "DIDMOAD", "(", "C0011848#ent", "<e2>", "diabetes", "mellitus", "C0338508#ent", "<e1>", "and", "deafness", ")", "."], "h": {"id": "C0338508", "name": "C0338508#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [15, 16]}}
{"token": ["Wolfram", "syndrome(WFS", "DIDMOAD", "syndrome", ")", "is", "an", "autosomal", "recessive", "neurodegenerative", "disorder", "by", "juvenile-onset", ",", "insulin-dependent", "diabetes", "mellitus", "C0338508#ent", "<e1>", "often", "accompanied", "by", "other", "symptoms", "including", "C0011848#ent", "<e2>", "neurosensory", "deafness", "urinary", "tract", "neurological", "abnormalities"], "h": {"id": "C0338508", "name": "C0338508#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [25, 26]}}
{"token": ["C0007965#ent", "<e1>", "is", "related", "to", "one", "gene", ":", "C1705344#ent", "<e2>", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705344", "name": "C1705344#ent", "pos": [8, 9]}}
{"token": ["C0007965#ent", "<e1>", "results", "from", "mutations", "in", "the", "lysosomal", "trafficking", "regulator", "C1705344#ent", "<e2>", ")", "gene", ",", "which", "encodes", "a", "425-kD", "cytoplasmic", "protein", "unknown", "function", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705344", "name": "C1705344#ent", "pos": [10, 11]}}
{"token": ["The", "Chediak-Higashi", "syndrome", "C0007965#ent", "<e1>", ")", ",", "a", "life-threatening", "autosomal", "recessive", "disease", "frequent", "mutations", "in", "the", "C1705344#ent", "<e2>", "and", "its", "animal", "model", "the", "beige", "mouse", ",", "are", "both", "characterized", "by", "lysosomal", "defects", "accumulation", "of", "giant", "lysosomes", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705344", "name": "C1705344#ent", "pos": [16, 17]}}
{"token": ["However", ",", "very", "few", "cases", "have", "been", "reported", "with", "C0149520#ent", "<e1>", "ECG", "changes", "not", "due", "to", "C0151744#ent", "<e2>"], "h": {"id": "C0149520", "name": "C0149520#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [16, 17]}}
{"token": ["Based", "on", "the", "literature", "and", "our", "personal", "experience", "although", "ECG", "changes", "may", "occur", "in", "C0149520#ent", "<e1>", "the", "possibility", "of", "C0151744#ent", "<e2>", "be", "excluded", "."], "h": {"id": "C0149520", "name": "C0149520#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [19, 20]}}
{"token": ["Farnesyl", "protein", "transferase", "C0016384#ent", "<e1>", ")", "or", "geranylgeranyl", "protein", "transferase", "I", "GGTase", "I", "were", "used", "to", "conjugate", "C1417388#ent", "<e2>", "and", "GGPP", "with", "fluorescent", "dansylated", "peptides", "."], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417388", "name": "C1417388#ent", "pos": [17, 18]}}
{"token": ["Immunohistochemistry", "revealed", "strong", "C2932861#ent", "<e1>", "expression", "on", "the", "endothelium", "of", "conduit", "vessels", "in", "C2987364#ent", "<e2>", "(", "WT", ")", "mice", "."], "h": {"id": "C2932861", "name": "C2932861#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "C0023816#ent", "<e1>", "mRNA", ",", "relative", "to", "C1384510#ent", "<e2>", "mRNA", ",", "was", "similar", "in", "both", "groups", "of", "rats", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1384510", "name": "C1384510#ent", "pos": [8, 9]}}
{"token": ["Src", "homology", "region", "2", "SH2", ")", "domain-containing", "phosphatase", "1", "SHP-1", ";", "previously", "named", "HCP", ",", "PTP1C", ",", "C1384543#ent", "<e1>", ",", "and", "SHP", ")", "is", "a", "C1335055#ent", "<e2>", "contains", "two", "SH2", "domains"], "h": {"id": "C1384543", "name": "C1384543#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335055", "name": "C1335055#ent", "pos": [25, 26]}}
{"token": ["C1384543#ent", "<e1>", "HePTP", ")", "is", "a", "38kDa", "C1335055#ent", "<e2>", "PTP", ")", "that", "is", "strongly", "expressed", "in", "T", "cells"], "h": {"id": "C1384543", "name": "C1384543#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335055", "name": "C1335055#ent", "pos": [7, 8]}}
{"token": ["This", "observation", ",", "plus", "our", "inability", "to", "demonstrate", "either", "an", "antiinflammatory", "effect", "intracerebroventricular", "dexamethasone", "a", "C0085387#ent", "<e1>", "or", "a", "pro-inflammatory", "influence", "of", "prostaglandin", "E2", "suggests", "that", "C3540754#ent", "<e2>", "are", "not", "important", "to", "central", "modulation", "inflammation", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [26, 27]}}
{"token": ["Use", "of", "a", "C0085387#ent", "<e1>", "prevented", "the", "efflux", "of", "C3540754#ent", "<e2>", ",", "but", "had", "no", "effect", "creatine", "kinase", "efflux", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [9, 10]}}
{"token": ["We", "used", "cultured", "fibroblasts", "from", "a", "case", "of", "C0023931#ent", "<e1>", "in", "which", "the", "mutant", "alpha", "2(I)", "C0002085#ent", "<e2>", "produces", "mRNA", "with", "exon", "16", "due", "to", "a", "point", "mutation", "in", "the", "splice", "donor", "site"], "h": {"id": "C0023931", "name": "C0023931#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [16, 17]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "describe", "the", "skeletal", "manifestations", "C0268164#ent", "<e1>", "PH1", ")", ",", "the", "most", "common", "of", "the", "primary", "C0020500#ent", "<e2>", "."], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [22, 23]}}
{"token": ["Early", "hepatorenal", "grafting", "uremia", "secondary", "to", "hyperoxaluria", "type", "1", "would", "avoid", "the", "deleterious", "clinical", "consequences", "of", "C0268164#ent", "<e1>", "shorten", "the", "duration", "of", "C0020500#ent", "<e2>", "which", "may", "compromise", "the", "course", "of", "kidney", "graft"], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [16, 17]}, "relation": "has_manifestation", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [22, 23]}}
{"token": ["At", "the", "posttranslational", "level", ",", "alpha-tocopherol", "inhibits", "C0033634#ent", "<e1>", "5-lipoxygenase", "and", "phospholipase", "A2", "activates", "protein", "phosphatase", "2A", "C1414034#ent", "<e2>"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414034", "name": "C1414034#ent", "pos": [17, 18]}}
{"token": ["To", "the", "last", "group", "belong", "C0033634#ent", "<e1>", "5-lipoxygenase", "inhibition", "post-translational", "level", "as", "well", "as", "alpha-tocopherol", "activation", "protein", "phosphatase", "2A", "C1414034#ent", "<e2>"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414034", "name": "C1414034#ent", "pos": [19, 20]}}
{"token": ["Patients", "with", "an", "acute", "myocardial", "infarction", "C0340293#ent", "<e1>", ")", "are", "of", "high", "risk", "develop", "ischemia-induced", "ventricular", "arrhythmias", "leading", "to", "sudden", "cardiac", "death", "C1419846#ent", "<e2>", ")", "in", "about", "one", "third", "of", "all", "C0340293#ent", "<e1>", "patients", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419846", "name": "C1419846#ent", "pos": [22, 23]}}
{"token": ["ACEIs", "have", "proven", "beneficial", "in", "improving", "left", "ventricular", "remodeling", "following", "an", "C0340293#ent", "<e1>", "while", "contributing", "to", "a", "reduction", "in", "sudden", "cardiac", "death", "C1419846#ent", "<e2>", ")", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419846", "name": "C1419846#ent", "pos": [22, 23]}}
{"token": ["IL-2", ",", "IL-5", ",", "and", "C1418824#ent", "<e1>", "-", "6", "do", "not", "induce", "C1419275#ent", "<e2>", "in", "culture", "."], "h": {"id": "C1418824", "name": "C1418824#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419275", "name": "C1419275#ent", "pos": [12, 13]}}
{"token": ["Immunokinase", "assays", "of", "Lck", "and", "Fyn", "precipitated", "from", "untreated", "or", "anti-CD45-treated", "C2987364#ent", "<e1>", "transfectants", "demonstrated", "that", "C1870006#ent", "<e2>", "cross-linking", "dephosphorylated", "Lck", "and", "reduced", "its", "capacity", "to", "phosphorylate", "enolase", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [16, 17]}}
{"token": ["By", "examining", "Lck", "autophosphorylation", "we", "find", "that", "Fc", "epsilon", "RI", "aggregation", "induces", "an", "increase", "in", "Lck", "enzymatic", "activity", "only", "in", "C2987364#ent", "<e1>", "Jurkat", "and", "the", "CD45-deficient", "Jurkat", "reconstituted", "with", "chimeric", "C1870006#ent", "<e2>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [30, 31]}}
{"token": ["To", "evaluate", "the", "association", "of", "autoantibodies", "to", "complement-fixing", "sympathetic", "ganglia", "(", "CF-SG", ")", ",", "and", "tyrosine", "phosphatase", "C1419119#ent", "<e1>", ")", "with", "electrocardiogram", "(ECG)-based", "C0259749#ent", "<e2>", "CAN", ")", "in", "long-term", "IDDM", "."], "h": {"id": "C1419119", "name": "C1419119#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0259749", "name": "C0259749#ent", "pos": [23, 24]}}
{"token": ["Moderate", "to", "severe", "C0850758#ent", "<e1>", "insertion", "is", "closely", "associated", "with", "development", "of", "C1710621#ent", "<e2>"], "h": {"id": "C0850758", "name": "C0850758#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1710621", "name": "C1710621#ent", "pos": [12, 13]}}
{"token": ["Acute", "exposure", "to", "elevated", "amino", "acid", "concentrations", "increased", "ribosomal", "protein", "S6", "kinase", "phosphorylation", "a", "rapamycin-sensitive", "mechanism", ",", "suggesting", "that", "C3539947#ent", "<e1>", "stimulated", "mammalian", "target", "of", "rapamycin", "(", "C1414805#ent", "<e2>", ")", "signaling", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1414805", "name": "C1414805#ent", "pos": [27, 28]}}
{"token": ["Exogenous", "C1705691#ent", "<e1>", ",", "but", "not", "C1539355#ent", "<e2>", ",", "can", "transactivate", "GM-CSF", ",", "through", "the", "GM5", "site", ",", "in", "a", "PMA/ionomycin", "dependent", "manner", "."], "h": {"id": "C1705691", "name": "C1705691#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1539355", "name": "C1539355#ent", "pos": [6, 7]}}
{"token": ["Although", "a", "single", "case", "can", "prove", "little", ",", "our", "case", "provides", "further", "evidence", "for", "the", "presumption", "that", "noncross-reactivity", "exists", "between", "C0009079#ent", "<e1>", "and", "other", "C0040615#ent", "<e2>", "the", "induction", "of", "agranulocytosis", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [20, 21]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [24, 25]}}
{"token": ["Second", ",", "we", "analyzed", "the", "ability", "of", "C2987364#ent", "<e1>", "HPV-6", "E7", "destabilize", "the", "other", "C1334895#ent", "<e2>", "family", "members", "p107", "and", "p130", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334895", "name": "C1334895#ent", "pos": [14, 15]}}
{"token": ["While", "it", "is", "a", "difficult", "C1416596#ent", "<e1>", "to", "exclude", "a", "role", "of", "MLH3", "in", "C0879290#ent", "<e2>", ",", "our", "study", "could", "not", "confirm", "a", "role", "for", "MLH3", "in", "CRC", "predisposition", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0879290", "name": "C0879290#ent", "pos": [14, 15]}}
{"token": ["C0007407#ent", "<e1>", "is", "involved", "in", "the", "catabolism", "of", "dopamine", ",", "and", "C3815636#ent", "<e2>", "is", "the", "rate-limiting", "enzyme", "for", "serotonin", "synthesis", "."], "h": {"id": "C0007407", "name": "C0007407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3815636", "name": "C3815636#ent", "pos": [11, 12]}}
{"token": ["Hepatic", "microvesicular", "fat", "MVF", ")", "has", "been", "associated", "with", "clinical", "syndromes", "C0085605#ent", "<e1>", "such", "as", "C4025020#ent", "<e2>", "pregnancy", "and", "Reye's", "syndrome", "."], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4025020", "name": "C4025020#ent", "pos": [15, 16]}}
{"token": ["HLA", "phenotypes", "were", "determined", "in", "109", "patients", "with", "rheumatic", "fever", "RF", ")", ",", "48", "patients", "with", "C0043407#ent", "<e1>", "YA", ")", ",", "86", "patients", "with", "chronic", "rheumatic", "heart", "disease", "C0035439#ent", "<e2>", ")", ",", "and", "326", "controls", "."], "h": {"id": "C0043407", "name": "C0043407#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035439", "name": "C0035439#ent", "pos": [28, 29]}}
{"token": ["HLA", "phenotypes", "were", "determined", "in", "109", "patients", "with", "rheumatic", "fever", "RF", ")", ",", "48", "patients", "with", "C0043407#ent", "<e1>", "YA", ")", ",", "86", "patients", "with", "C0035439#ent", "<e2>", "RHD", ")", ",", "and", "326", "controls", "."], "h": {"id": "C0043407", "name": "C0043407#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035439", "name": "C0035439#ent", "pos": [24, 25]}}
{"token": ["The", "effects", "of", "7-day", "infusion", "with", "C0024027#ent", "<e1>", ",", "a", "potent", "competitive", "inhibitor", "of", "C0063164#ent", "<e2>", "HMG-CoA", ")", "reductase", ",", "on", "the", "adrenal", "zona", "fasciculata", "examined", "in", "normal", "and", "dexamethasone/ACTH-treated", "rats", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0063164", "name": "C0063164#ent", "pos": [14, 15]}}
{"token": ["This", "study", "examines", "gene", "expression", "the", "sterol", "pathway", "response", "to", "C0024027#ent", "<e1>", ",", "an", "inhibitor", "of", "C0063164#ent", "<e2>", "Hmg1p", ")", ",", "and", "fluconazole", ",", "an", "inhibitor", "of", "14", "alpha-lanosterol", "demethylase", "Erg11p", ")", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0063164", "name": "C0063164#ent", "pos": [16, 17]}}
{"token": ["Promoter", "methylation", "tumor", "suppressor", "C0596240#ent", "<e1>", "occurs", "in", "C1709246#ent", "<e2>", "increases", "with", "age", ",", "and", "ultimately", "silences", "gene", "function", "constitute", "a", "field-defect", "that", "may", "predispose", "tissues", "to", "gastric", "cancer", "evolution", "."], "h": {"id": "C0596240", "name": "C0596240#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709246", "name": "C1709246#ent", "pos": [8, 9]}}
{"token": ["However", ",", "recent", "evidence", "has", "suggested", "that", "the", "C0078939#ent", "<e1>", "FAF", "are", "related", "to", "C1415323#ent", "<e2>", ",", "an", "actin", "modulating", "protein", "."], "h": {"id": "C0078939", "name": "C0078939#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415323", "name": "C1415323#ent", "pos": [14, 15]}}
{"token": ["These", "included", "C1318711#ent", "<e1>", "varicella-zoster", ",", "cytomegalo", ",", "subacute", "sclerosing", "panencephalitis", "progressive", "C0023524#ent", "<e2>", "Japanese", "B", "encephalitis", "measles", ",", "acute", "hemorrhagic", "conjunctivitis", "Lassa", "and", "Korean", "hemorrhagic", "fever"], "h": {"id": "C1318711", "name": "C1318711#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [12, 13]}}
{"token": ["The", "improvement", "seems", "to", "be", "related", "to", "a", "better", "reactivity", "of", "HCV", "C0030956#ent", "<e1>", "rather", "than", "to", "the", "inclusion", "of", "the", "new", "determinant", "C1969057#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1969057", "name": "C1969057#ent", "pos": [23, 24]}}
{"token": ["Aspirin", "and", "C0040207#ent", "<e1>", ",", "but", "not", "oral", "anticoagulants", "reinforce", "the", "treatment", "of", "C0852949#ent", "<e2>", "the", "lower", "limbs"], "h": {"id": "C0040207", "name": "C0040207#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0852949", "name": "C0852949#ent", "pos": [13, 14]}}
{"token": ["This", "paper", "evaluates", "the", "antiaggregant", "action", "C0040207#ent", "<e1>", "and", "nifedipine", "in", "patients", "with", "obliterate", "C0852949#ent", "<e2>", "in", "inferior", "limbs", "arteriosclerotic", "etiology", "(", "OAIL", ")", "."], "h": {"id": "C0040207", "name": "C0040207#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0852949", "name": "C0852949#ent", "pos": [14, 15]}}
{"token": ["Importantly", ",", "a", "multimerization-defective", "NC", "mutant", "displayed", "C2987364#ent", "<e1>", "levels", "of", "membrane", "binding", "DRM", "association", ",", "indicating", "that", "NC-mediated", "C0017346#ent", "<e2>", "multimerization", "is", "dispensable", "for", "association", "of", "C0017346#ent", "<e2>", "with", "membrane", "or", "DRM", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [19, 20]}}
{"token": ["Cotransfection", "experiments", "with", "Y36S-L41P", "and", "C2987364#ent", "<e1>", "proviral", "DNAs", "revealed", "that", "the", "mutant", "C0017346#ent", "<e2>", "dominantly", "blocked", "the", "incorporation", "of", "Env", "by", "C2987364#ent", "<e1>", "C0017346#ent", "<e2>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [13, 14]}}
{"token": ["Cells", "transfected", "with", "mutant", "or", "C2987364#ent", "<e1>", "clones", "produced", "similar", "levels", "of", "Tat", ",", "C0017346#ent", "<e2>", ",", "Pol", ",", "and", "Env", "proteins", "formed", "syncytia", ",", "and", "shed", "viruslike", "particles", "were", "indistinguishable", "by", "electron", "microscopy"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [14, 15]}}
{"token": ["Characterization", "of", "the", "[32P]PtdInsP", "products", "formed", "by", "the", "purified", "C0089793#ent", "<e1>", "that", "these", "C3540772#ent", "<e2>", "specifically", "phosphorylated", "the", "D-4", "position", "of", "the", "inositol", "ring"], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [13, 14]}}
{"token": ["The", "immune", "adjuvant", "interferon-gamma", "and", "the", "C0003308#ent", "<e1>", "itraconazole", "have", "reduced", "the", "incidence", "of", "infections", "in", "C1844376#ent", "<e2>", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1844376", "name": "C1844376#ent", "pos": [16, 17]}}
{"token": ["Of", "four", "spontaneously", "arising", "tumors", "previously", "classified", "as", "carcinoma", ",", "Sp4", "possessed", "epithelial", "features", "on", "both", "ultrastructural", "and", "immunocytochemical", "analysis", "C2984536#ent", "<e1>", "on", "ultrastructural", "analysis", "and", "Sp15", "and", "C1423960#ent", "<e2>", "by", "neither", "technique", "."], "h": {"id": "C2984536", "name": "C2984536#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1423960", "name": "C1423960#ent", "pos": [28, 29]}}
{"token": ["There", "were", "focuses", "of", "typhus", ",", "C0030528#ent", "<e1>", "tuberculosis", ",", "diphtheria", ",", "scarlet", "fever", "and", "C0025297#ent", "<e2>", "."], "h": {"id": "C0030528", "name": "C0030528#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [15, 16]}}
{"token": ["Mice", "infected", "with", "secondary", "cysts", "Echinococcus", "granulosus", "treated", "ig", "with", "mebendazole", "(", "Meb", ")", ",", "albendazole", "(", "Alb", ")", ",", "C1142644#ent", "<e1>", "AlbSO", ")", "or", "C0001911#ent", "<e2>", "AlbSP", ")", "at", "equal", "effective", "dosage", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0001911", "name": "C0001911#ent", "pos": [25, 26]}}
{"token": ["Eighty-five", "per", "cent", "of", "the", "cases", "of", "Alport", "syndrome", "due", "to", "a", "mutation", "in", "the", "C1413586#ent", "<e1>", "located", "on", "chromosome", "X", "encoding", "the", "C2347825#ent", "<e2>"], "h": {"id": "C1413586", "name": "C1413586#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2347825", "name": "C2347825#ent", "pos": [23, 24]}}
{"token": ["Mutation", "analysis", "a", "single", "base", "insertion", "in", "C1413586#ent", "<e1>", "which", "was", "predicted", "to", "cause", "a", "major", "structural", "defect", "the", "C2347825#ent", "<e2>"], "h": {"id": "C1413586", "name": "C1413586#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2347825", "name": "C2347825#ent", "pos": [19, 20]}}
{"token": ["The", "C1565860#ent", "<e1>", "inhibitory", "activities", "of", "C0175820#ent", "<e2>", "from", "these", "fruits", "were", "comparable", "to", "those", "of", "ibuprofen", "and", "naproxen", "at", "10", "microM", "concentrations", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0175820", "name": "C0175820#ent", "pos": [6, 7]}}
{"token": ["C0720099#ent", "<e1>", "of", "immobility", "during", "the", "C1414830#ent", "<e2>", "20", "min", "and", "5", "min", "was", "28", "and", "30", "%", "shorter", ",", "respectively", ",", "than", "in", "controls", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414830", "name": "C1414830#ent", "pos": [6, 7]}}
{"token": ["TFPC", "was", "found", "to", "reduce", "the", "C0720099#ent", "<e1>", "of", "immobility", "in", "the", "C1414830#ent", "<e2>", "without", "accompanying", "changes", "in", "ambulatory", ",", "rearing", "and", "grooming", "behaviors", "the", "open-field", "test"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414830", "name": "C1414830#ent", "pos": [12, 13]}}
{"token": ["The", "degree", "of", "the", "depression-like", "state", "was", "measured", "by", "the", "animal", "'s", "C0720099#ent", "<e1>", "of", "immobility", "using", "the", "forced", "swimming", "test", "C1414830#ent", "<e2>", ")", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414830", "name": "C1414830#ent", "pos": [21, 22]}}
{"token": ["He", "had", "childhood", "poliomyelitis", "and", ",", "while", "showing", "no", "evidence", "of", "C0080040#ent", "<e1>", "demonstrated", "excessive", "sensitivity", "to", "C0010464#ent", "<e2>", "developed", "prolonged", "muscle", "weakness", "the", "postoperative", "period", "."], "h": {"id": "C0080040", "name": "C0080040#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010464", "name": "C0010464#ent", "pos": [17, 18]}}
{"token": ["In", "total", ",", "these", "results", "firmly", "establish", "that", "a", "major", "C0080054#ent", "<e1>", "phosphorylation", "site", "on", "the", "C0297817#ent", "<e2>", "near", "the", "N-terminal", "end", "serine-20", ",", "which", "is", "found", "within", "the", "sequence", "Ser-Pro-Leu-Lys-Arg-Leu", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0297817", "name": "C0297817#ent", "pos": [16, 17]}}
{"token": ["The", "C0127400#ent", "<e1>", "role", "of", "C0257535#ent", "<e2>", "cPLA2", "activation", "was", "further", "demonstrated", "after", "a", "treatment", "with", "anisomycin", ",", "a", "very", "effective", "activator", "of", "C0257535#ent", "<e2>"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [5, 6]}}
{"token": ["The", "IgE-dependent", "release", "of", "these", "C0127400#ent", "<e1>", "in", "basophils", "crucially", "involves", "PI", "3-kinase", "the", "subsequent", "activation", "of", "C0257535#ent", "<e2>", "ERK1&2", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [17, 18]}}
{"token": ["It", "establishes", "that", "endogenous", "NO", "homeostatically", "opposes", "angiotensin", "II-alpha1-mediated", "renal", "vasoconstriction", ",", "and", "that", "the", "C3537240#ent", "<e1>", "role", "of", "NO", "is", "diminished", "in", "C0022660#ent", "<e2>", "."], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [23, 24]}}
{"token": ["To", "evaluate", "the", "protective", "properties", "peptides", "related", "functionally", "and/or", "structurally", "to", "vasoactive", "intestinal", "peptide", "C1705713#ent", "<e1>", ")", ",", "PC12", "cultures", "were", "treated", "with", "C0021974#ent", "<e2>", "as", "a", "model", "for", "neuronal", "ischemic/hypoxic", "injury", "."], "h": {"id": "C1705713", "name": "C1705713#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0021974", "name": "C0021974#ent", "pos": [23, 24]}}
{"token": ["The", "role", "and", "behavior", "of", "the", "salvage", "C3541394#ent", "<e1>", "in", "the", "biosynthesis", "of", "purines", "(", "adenine", "and", "C0020687#ent", "<e2>", "and", "pyrimidines", "(", "uridine-cytidine", ",", "deoxycytidine", "and", "thymidine", "kinases", "were", "elucidated", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020687", "name": "C0020687#ent", "pos": [17, 18]}}
{"token": ["The", "results", "suggested", "that", "the", "Fru-2", ",", "6-P2ases", "in", "the", "bifunctional", "C0027203#ent", "<e1>", "and", "in", "the", "separated", "C0016755#ent", "<e2>", "in", "two", "different", "conformation", "and", "activity", "states"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0016755", "name": "C0016755#ent", "pos": [17, 18]}}
{"token": ["We", "found", "that", "levels", "of", "cyclooxygenase-2", "and", "C4082268#ent", "<e1>", "commonly", "increased", "whereas", "the", "amount", "of", "C0044894#ent", "<e2>", "was", "frequently", "decreased", "in", "NSCLC", "compared", "with", "adjacent", "normal", "lung", "."], "h": {"id": "C4082268", "name": "C4082268#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0044894", "name": "C0044894#ent", "pos": [15, 16]}}
{"token": ["This", "C1413746#ent", "<e1>", "been", "highly", "purified", "from", "C3179066#ent", "<e2>", "by", "using", "a", "combination", "of", "high-salt", "extraction", ",", "ammonium", "sulfate", "precipitation", ",", "heparin-agarose", "chromatography", "and", "sequence-specific", "DNA-affinity", "chromatography", "."], "h": {"id": "C1413746", "name": "C1413746#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [7, 8]}}
{"token": ["Phylogenetic", "analysis", "that", "the", "C1334043#ent", "<e1>", "can", "be", "classified", "into", "a", "distinct", "group", "of", "MAPKAPK", "and", ",", "therefore", ",", "the", "identified", "C1334043#ent", "<e1>", "was", "designated", "as", "C1452441#ent", "<e1>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1452441", "name": "C1452441#ent", "pos": [26, 27]}}
{"token": ["The", "treatment", "also", "showed", "significant", "correction", "in", "the", "level", "of", "nitric", "oxide", "radicals", "superoxide", "radicals", "peroxynitrite", "radical", "lipid", "peroxidation", "glutathione", ",", "C0017824#ent", "<e1>", "glutathione-S-transferase", ",", "glutathione", "peroxidase", "superoxide", "dismutase", "catalase", "in", "the", "pancreas", "of", "C0030086#ent", "<e2>", "diabetic", "rats", "."], "h": {"id": "C0017824", "name": "C0017824#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0030086", "name": "C0030086#ent", "pos": [34, 35]}}
{"token": ["C0009450#ent", "<e1>", "special", "concern", "include", "hepatitis", "B", "C", ",", "C0039128#ent", "<e2>", ",", "human", "immunodeficiency", "virus", "infection", "tuberculosis", ",", "and", "presence", "of", "intestinal", "parasites", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [9, 10]}}
{"token": ["It", "was", "essential", "to", "decide", "whether", "the", "clinical", "symptoms", "nausea", "and", "fever", "without", "exanthema", "or", "C0014034#ent", "<e1>", "were", "related", "to", "a", "HIV-seroconversion", ",", "a", "C0019159#ent", "<e2>", "a", "hepatotoxic", "reaction", "to", "the", "medication", "administered", "."], "h": {"id": "C0014034", "name": "C0014034#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [24, 25]}}
{"token": ["Mature", "ghrelin", "was", "produced", "by", "human", "furin", ",", "C0135615#ent", "<e1>", "and", "human", "C1258132#ent", "<e2>", "not", "by", "mouse", "prohormone", "convertase", "2"], "h": {"id": "C0135615", "name": "C0135615#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1258132", "name": "C1258132#ent", "pos": [12, 13]}}
{"token": ["These", "precursors", "are", "cut", "into", "pieces", "by", "C0135615#ent", "<e1>", "more", "precisely", "those", "called", "C1258132#ent", "<e2>", "PCs", ")", "that", "cleave", "at", "the", "C", "terminus", "of", "basic", "doublets", "."], "h": {"id": "C0135615", "name": "C0135615#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1258132", "name": "C1258132#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "CypA", "inhibits", "CD4+", "T", "cell", "signal", "transduction", "the", "absence", "of", "C0010592#ent", "<e1>", "via", "a", "regulatory", "proline", "residue", "in", "C1567665#ent", "<e2>", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1567665", "name": "C1567665#ent", "pos": [20, 21]}}
{"token": ["The", "results", "demonstrated", "that", "C0010592#ent", "<e1>", "reduced", "in", "vitro", "T-cell", "responses", "to", "C1567665#ent", "<e2>", "suppressed", "in", "vivo", "delayed-type", "hypersensitivity", "tuberculin", "skin-test", "reactions", ",", "and", "impaired", "the", "development", "of", "native", "resistance", "to", "salmonellosis", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1567665", "name": "C1567665#ent", "pos": [12, 13]}}
{"token": ["The", "phosphorylation", "of", "C0243650#ent", "<e1>", "to", "occur", "in", "vivo", "cells", "with", "an", "elevated", "level", "of", "C1709130#ent", "<e2>", "contained", "more", "farnesyl", "triphosphate", "did", "control", "cells"], "h": {"id": "C0243650", "name": "C0243650#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1709130", "name": "C1709130#ent", "pos": [15, 16]}}
{"token": ["The", "serological", "determinants", "Rodgers", "(", "Rg1", ",", "Rg2", ")", "and", "Chido", "(", "Ch1", ",", "Ch2", ",", "C0769345#ent", "<e1>", ")", "are", "generally", "associated", "with", "C4A", "and", "C1413000#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413000", "name": "C1413000#ent", "pos": [25, 26]}}
{"token": ["RAAS", "blockade", "with", "angiotensin", "converting", "enzyme", "inhibitors", "ACEIs", ")", "and/or", "angiotensin", "receptor", "AT(1)", "blockers", "ARBs", ")", "is", "very", "useful", "for", "the", "treatment", "of", "arterial", "hypertension", "chronic", "heart", "failure", "C0019099#ent", "<e1>", ")", ",", "atherosclerosis", "and", "C0011849#ent", "<e2>", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [34, 35]}}
{"token": ["To", "explore", "the", "characteristics", "of", "Chinese", "medicinal", "treatment", "302", "chronic", "heart", "failure", "C0019099#ent", "<e1>", ")", "patients", "of", "coronary", "heart", "disease", "C0011849#ent", "<e2>", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [20, 21]}}
{"token": ["We", "also", "demonstrate", "that", "C1366490#ent", "<e1>", "and", "the", "C1421313#ent", "<e2>", "beta-arrestin", "associate", "with", "the", "receptor", ",", "forming", "a", "macromolecular", "complex", "after", "MCP-1", "binding", "."], "h": {"id": "C1366490", "name": "C1366490#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421313", "name": "C1421313#ent", "pos": [8, 9]}}
{"token": ["Interferon-gamma", "(", "IFN-gamma", ")", "induces", "the", "transcription", "of", "the", "C0079429#ent", "<e1>", "encoding", "a", "C1415004#ent", "<e2>", "activating", "a", "latent", "cytoplasmic", "factor", "GAF", "(", "gamma-activated", "factor", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415004", "name": "C1415004#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "the", "retinoic", "acid", "enzymes", "C1412333#ent", "<e1>", "and", "Raldh3", "were", "significantly", "changed", "in", "the", "mutant", "C0235267#ent", "<e2>", "."], "h": {"id": "C1412333", "name": "C1412333#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [17, 18]}}
{"token": ["First", ",", "we", "show", "that", "activity", "of", "C3274857#ent", "<e1>", "is", "required", "for", "FcepsilonR1-mediated", "C2985456#ent", "<e2>", "dephosphorylation", "and", "nuclear", "import"], "h": {"id": "C3274857", "name": "C3274857#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2985456", "name": "C2985456#ent", "pos": [13, 14]}}
{"token": ["C0032002#ent", "<e1>", "craniotomy", "showed", "typical", "features", "of", "C0342410#ent", "<e2>"], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0342410", "name": "C0342410#ent", "pos": [7, 8]}}
{"token": ["It", "has", "been", "shown", "to", "be", "effective", "in", "treating", "pain", "caused", "by", "C0037763#ent", "<e1>", "conditions", "other", "than", "C0030794#ent", "<e2>", "by", "muscular", "hypertonicity"], "h": {"id": "C0037763", "name": "C0037763#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030794", "name": "C0030794#ent", "pos": [17, 18]}}
{"token": ["The", "first", "evidence", "for", "C0085536#ent", "<e1>", "signalling", "pathways", "plants", "is", "presented", "by", "characterizing", "a", "C1335554#ent", "<e2>", "the", "unicellular", "green", "alga", "Chlamydomonas", "eugametos"], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [14, 15]}}
{"token": ["C0085536#ent", "<e1>", "PTP1B", ")", "is", "a", "C1335554#ent", "<e2>", "unknown", "function", ",", "although", "increasing", "evidence", "supports", "a", "role", "for", "this", "phosphatase", "in", "insulin", "action"], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [6, 7]}}
{"token": ["C0030817#ent", "<e1>", "(", "beta", ",", "beta-dimethyl", "cysteine", "is", "an", "C0003191#ent", "<e2>", "a", "poorly", "understood", "mechanism", "of", "action", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003191", "name": "C0003191#ent", "pos": [9, 10]}}
{"token": ["A", "33", "C0059256#ent", "<e1>", "detected", "in", "C1875400#ent", "<e2>", "that", "lacked", "Fc-binding", "activity", "but", "not", "in", "C1875400#ent", "<e2>", "that", "bound", "Fc", "."], "h": {"id": "C0059256", "name": "C0059256#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}}
{"token": ["The", "production", "of", "26", "C0059256#ent", "<e1>", "also", "observed", "in", "the", "polymyxin-resistant", "C1875400#ent", "<e2>", "grown", "in", "the", "medium", "containing", "low", "concentrations", "of", "NaCl", "(", "0.2", "%", "and", "0.5", "%", ")", "."], "h": {"id": "C0059256", "name": "C0059256#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [11, 12]}}
{"token": ["A", "significant", "correlation", "was", "found", "between", "expressions", "of", "CD30v", "and", "C1705984#ent", "<e1>", "ligand", "transcripts", "in", "AML", "and", "C1422646#ent", "<e2>", "(", "P", "=", "0.02", ",", "odds", "ratio", "3.2", ")", "."], "h": {"id": "C1705984", "name": "C1705984#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1422646", "name": "C1422646#ent", "pos": [17, 18]}}
{"token": ["It", "was", "concluded", "that", "C0717703#ent", "<e1>", "caused", "significantly", "less", "gastroduodenal", "damage", "than", "C0012091#ent", "<e2>", ",", "but", "was", "as", "effective", "as", "C0012091#ent", "<e2>", "alone", "in", "the", "treatment", "of", "rheumatoid", "arthritis"], "h": {"id": "C0717703", "name": "C0717703#ent", "pos": [4, 5]}, "relation": "has_constitutional_part", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [12, 13]}}
{"token": ["Previous", "studies", "in", "osteoarthritis", "and", "rheumatoid", "arthritis", "established", "C0717703#ent", "<e1>", "to", "be", "as", "effective", "as", "C0012091#ent", "<e2>", "but", "with", "significantly", "less", "gastrointestinal", "damage", "Verdickt", "et", "al.", "1992", ")", "."], "h": {"id": "C0717703", "name": "C0717703#ent", "pos": [8, 9]}, "relation": "has_constitutional_part", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [15, 16]}}
{"token": ["The", "C1333576#ent", "<e1>", "first", "identified", "as", "a", "C0694890#ent", "<e2>", "involved", "in", "progression", "of", "mouse", "T", "cell", "lymphomas"], "h": {"id": "C1333576", "name": "C1333576#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [7, 8]}}
{"token": ["C0700465#ent", "<e1>", "and", "flecainide", "appear", "equally", "effective", "in", "converting", "recent", "onset", "C0004238#ent", "<e2>", "."], "h": {"id": "C0700465", "name": "C0700465#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C0700465#ent", "<e1>", "is", "effective", "in", "terminating", "supraventricular", "tachycardias", "C0004238#ent", "<e2>", "in", "the", "vast", "majority", "of", "patients", "."], "h": {"id": "C0700465", "name": "C0700465#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [10, 11]}}
{"token": ["The", "unexpected", "finding", "that", "phentolamine", "did", "not", "ameliorate", "pain", "in", "patients", "with", "C0002962#ent", "<e1>", "casts", "doubts", "as", "to", "whether", "C0017887#ent", "<e2>", "relieves", "anginal", "pain", "lowering", "the", "systemic", "arterial", "pressure"], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [19, 20]}}
{"token": ["Presence", "of", "C0002962#ent", "<e1>", "claudication", "intermittens", ",", "use", "of", "C0017887#ent", "<e2>", "were", "questioned", ",", "a", "resting", "ECG", "and", "a", "distal", "arterial", "pressure", "use", "of", "doppler", "technique", "the", "lower", "limbs", "determined", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [9, 10]}}
{"token": ["Apolipoprotein", "E", "C1412481#ent", "<e1>", ")", "genotype", "is", "the", "most", "influential", "C0002395#ent", "<e2>", "AD", ")", "risk", "factor", "advanced", "age"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [10, 11]}}
{"token": ["We", "studied", "C4049625#ent", "<e1>", "burden", "variability", "in", "patients", "paced", "for", "sinus", "node", "disease", "C1822796#ent", "<e2>", ")", "in", "order", "to", "interpret", "currently", "published", "data", "and", "to", "evaluate", "reliable", "sample", "sizes"], "h": {"id": "C4049625", "name": "C4049625#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1822796", "name": "C1822796#ent", "pos": [13, 14]}}
{"token": ["The", "5-HT", "effect", "antagonized", "by", "pindolol", "or", "cyanopindolol", ",", "but", "not", "by", "C0037956#ent", "<e1>", ",", "ketanserin", "or", "C0063322#ent", "<e2>", "."], "h": {"id": "C0037956", "name": "C0037956#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0063322", "name": "C0063322#ent", "pos": [17, 18]}}
{"token": ["injection", "of", "methysergide", ",", "methiothepin", ",", "metergoline", "or", "C0037956#ent", "<e1>", "but", "not", "C0063322#ent", "<e2>", ",", "renzapride", "or", "ritanserin", "was", "effective", "in", "reversing", "5-HT-induced", "inhibition", "of", "acid", "secretion"], "h": {"id": "C0037956", "name": "C0037956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0063322", "name": "C0063322#ent", "pos": [12, 13]}}
{"token": ["Our", "findings", "indicate", "that", "guinea", "pig", "type", "II", "possess", "the", "enzymatic", "machinery", "necessary", "to", "convert", "arachidonic", "acid", "specific", "C0033551#ent", "<e1>", "which", "may", "suggest", "a", "role", "for", "these", "cells", "in", "C3714636#ent", "<e2>"], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [29, 30]}}
{"token": ["Chlamydia", "trachomatis", "a", "human", "pathogen", "that", "causes", "ocular", "disease", "trachoma", "and", "inclusion", "conjunctivitis", ",", "C0242354#ent", "<e1>", "cervicitis", ",", "urethritis", ",", "salpingitis", ",", "and", "C0024286#ent", "<e2>", ",", "and", "respiratory", "disease", "infant", "pneumonitis", "."], "h": {"id": "C0242354", "name": "C0242354#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024286", "name": "C0024286#ent", "pos": [23, 24]}}
{"token": ["C1710602#ent", "<e1>", "was", "detected", "in", "all", "gastrointestinal", "tissues", "in", "the", "C0036091#ent", "<e2>", "but", "not", "in", "extracts", "of", "liver", ",", "kidney", ",", "brain", ",", "heart", "atrium", "and", "adenohypophysis", "."], "h": {"id": "C1710602", "name": "C1710602#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [10, 11]}}
{"token": ["General", "anesthesia", "maintained", "with", "C0074414#ent", "<e1>", ",", "remifentanil", ",", "and", "C0042435#ent", "<e2>", "."], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [10, 11]}}
{"token": ["A", "21-year-old", "male", "with", "congenital", "PAI-1", "deficiency", "wisdom", "teeth", "extraction", "of", "the", "mandible", "under", "general", "anesthesia", "propofol", ",", "nitrous", "oxide", "C0074414#ent", "<e1>", ",", "fentanyl", ",", "and", "C0042435#ent", "<e2>", "."], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [26, 27]}}
{"token": ["These", "include", "early", "(", "e.g.", "C1448777#ent", "<e1>", ")", "and", "late", "(", "e.g.", "CDKN2C", ")", "C0243037#ent", "<e2>"], "h": {"id": "C1448777", "name": "C1448777#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0243037", "name": "C0243037#ent", "pos": [14, 15]}}
{"token": ["These", "C0029132#ent", "<e1>", "include", "inflammatory", "demyelinating", "neuropathies", "neuropathy", "and", "vasculitis", ",", "lower", "C0085084#ent", "<e2>", "and", "autonomic", "neuropathies"], "h": {"id": "C0029132", "name": "C0029132#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "the", "differential", "diagnosis", "unexplained", "C0029132#ent", "<e1>", "juvenile", "onset", ",", "particularly", "when", "associated", "with", "upper", "and", "lower", "C0085084#ent", "<e2>", "include", "biotinidase", "deficiency"], "h": {"id": "C0029132", "name": "C0029132#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [19, 20]}}
{"token": ["C0020402#ent", "<e1>", "is", "an", "old", "drug", "is", "often", "used", "to", "C0040028#ent", "<e2>", "polycythemia", "vera", "patients", "with", "high-risk", "disease"], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040028", "name": "C0040028#ent", "pos": [10, 11]}}
{"token": ["C0020402#ent", "<e1>", "(", "HU", ")", "has", "been", "used", "in", "patients", "with", "C0040028#ent", "<e2>", "ET", ")", "to", "reduce", "the", "frequency", "and", "severity", "of", "thrombotic", "complications", "of", "the", "disease", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040028", "name": "C0040028#ent", "pos": [11, 12]}}
{"token": ["Both", "selective", "cyclooxygenase", "(COX)-2", "inhibitors", "and", "non-steroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", "have", "been", "beneficial", "pharmacological", "agents", "many", "patients", "suffering", "from", "C0718667#ent", "<e2>", "inflammation", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0718667", "name": "C0718667#ent", "pos": [21, 22]}}
{"token": ["C3888277#ent", "<e1>", "blocked", "and", "reversed", ",", "both", "C1417858#ent", "<e2>", "morphological", "alterations", "and", "activation-associated", "changes", "in", "the", "actin", "cytoskeleton", "in", "quiescent", "and", "activated", "stellate", "cells", "respectively", "."], "h": {"id": "C3888277", "name": "C3888277#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417858", "name": "C1417858#ent", "pos": [7, 8]}}
{"token": ["The", "Cyp4a", "C1417679#ent", "<e1>", "are", "adjacent", "to", "the", "C1413887#ent", "<e2>", "with", "Cyp4a12", "most", "distant", "from", "Cyp4b1", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413887", "name": "C1413887#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "demonstrate", "that", "the", "signaling", "mechanism", "underlying", "stimulatory", "effects", "C3539623#ent", "<e1>", "on", "insulin", "gene", "transcription", "from", "C0033640#ent", "<e2>", "activation", "of", "the", "RIP1", "CRE", "."], "h": {"id": "C3539623", "name": "C3539623#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [17, 18]}}
{"token": ["Cystatin", "C", "one", "of", "a", "family", "of", "C1449702#ent", "<e1>", "cathepsins", "and", "other", "C0010656#ent", "<e2>"], "h": {"id": "C1449702", "name": "C1449702#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [12, 13]}}
{"token": ["Cystatins", "are", "C1449702#ent", "<e1>", "papain", "and", "related", "C0010656#ent", "<e2>"], "h": {"id": "C1449702", "name": "C1449702#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "we", "found", "that", "C2744579#ent", "<e1>", "volume", "increased", "35", "+", "/-", "7", "%", "after", "C0000477#ent", "<e2>", "treatment", ",", "which", "could", "be", "an", "early", "event", "inhibition", "of", "ML-1", "cell", "proliferation"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [15, 16]}}
{"token": ["This", "stable", "carboxypeptidase", "activity", "attributed", "to", "C0033993#ent", "<e1>", "unstable", "carboxypeptidase", "differs", "from", "C0003766#ent", "<e2>", "pH-optimum", ",", "esterase", "activity", "substrate", "specificity", "Co2", "+", "-activation", "and", "dithiotreitol", "activation", "."], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003766", "name": "C0003766#ent", "pos": [12, 13]}}
{"token": ["C0033993#ent", "<e1>", "a", "widely", "distributed", "\"", "C0003766#ent", "<e2>", "bound", "to", "plasma", "membranes"], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003766", "name": "C0003766#ent", "pos": [6, 7]}}
{"token": ["86Rb+", "efflux", "measurements", "of", "COSm6", "cells", "co-expressing", "Kir6.2", "and", "either", "C2987364#ent", "<e1>", "or", "delta", "F1388", "C1335290#ent", "<e2>", "revealed", "that", "the", "F1388", "mutation", "abolished", "ATP-sensitive", "potassium", "channel", "KATP", ")", "activity", "in", "intact", "cells", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335290", "name": "C1335290#ent", "pos": [15, 16]}}
{"token": ["To", "define", "its", "peripheral", "pharmacokinetics", ",", "we", "administered", "C0003596#ent", "<e1>", "by", "subcutaneous", "injection", ",", "by", "subcutaneous", "infusion", "and", "by", "intravenous", "infusion", "15", "patients", "with", "C0030567#ent", "<e2>", "and", "measured", "plasma", "C0003596#ent", "<e1>", "levels", "by", "high-performance", "liquid", "chromatography", "electrochemical", "detection"], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [24, 25]}, "relation": "may_be_treated_by", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [8, 9]}}
{"token": ["Four", "single-nucleotide", "polymorphisms", "been", "found", "in", "the", "human", "BUB1", "gene", "which", "encodes", "a", "C0031727#ent", "<e1>", "involved", "in", "the", "C3710678#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3710678", "name": "C3710678#ent", "pos": [18, 19]}}
{"token": ["The", "increased", "apoptosis", "coincided", "with", "a", "significant", "decrease", "in", "expression", "of", "BubR1", ",", "a", "C0031727#ent", "<e1>", "required", "for", "activation", "and", "maintenance", "of", "the", "C3710678#ent", "<e2>", "response", "to", "treatment", "with", "spindle", "poisons"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3710678", "name": "C3710678#ent", "pos": [23, 24]}}
{"token": ["To", "report", "the", "efficacy", "of", "Pamidronate", "to", "treat", "C0020437#ent", "<e1>", "in", "a", "patient", "with", "Williams-Beuren", "syndrome", "C0175702#ent", "<e2>", ")", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [16, 17]}}
{"token": ["Coadministration", "of", "the", "C0178601#ent", "<e1>", "SKF-38393", ",", "did", "not", "affect", "the", "C0009079#ent", "<e2>", "downregulation", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [11, 12]}}
{"token": ["The", "C0178601#ent", "<e1>", "iodosulpride", "and", "C0009079#ent", "<e2>", ",", "had", "no", "effect", "basal", "acidification", "but", "inhibited", "acidification", "responses", "in", "CHO", "cells", "quinpirole", "in", "an", "apparently", "competitive", "manner", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [5, 6]}}
{"token": ["We", "conclude", "that", "the", "combination", "of", "ATF3", "and", "c-Jun", "induces", "the", "anti-apoptotic", "factor", "C1333928#ent", "<e1>", ",", "which", "directly", "or", "indirectly", "activates", "C0812228#ent", "<e2>", ",", "and", "thereby", "possibly", "inhibits", "apoptosis", "and", "induces", "nerve", "elongation"], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [21, 22]}}
{"token": ["In", "normal", "histological", "appearance", "and", "C0017152#ent", "<e1>", "signs", "of", "exacerbation", "CP", "were", "not", "registered", "contrary", "to", "C0017154#ent", "<e2>", "CP", "irrespective", "of", "ulcer", "location", "."], "h": {"id": "C0017152", "name": "C0017152#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017154", "name": "C0017154#ent", "pos": [16, 17]}}
{"token": ["Statistical", "analysis", "the", "results", "in", "the", "various", "histological", "groups", "C0017152#ent", "<e1>", "and", "controls", "indicated", "that", "chronic", "superficial", "gastritis", "C0017154#ent", "<e2>", "not", "associated", "with", "reduced", "gastric", "acid", "secretion", "in", "Chinese", "subjects", "."], "h": {"id": "C0017152", "name": "C0017152#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017154", "name": "C0017154#ent", "pos": [18, 19]}}
{"token": ["The", "traditional", "grading", "of", "C0017152#ent", "<e1>", "was", "also", "done", "using", "the", "categories", "of", "superficial", "and", "C0017154#ent", "<e2>"], "h": {"id": "C0017152", "name": "C0017152#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017154", "name": "C0017154#ent", "pos": [15, 16]}}
{"token": ["C0005122#ent", "<e1>", "mimic", "many", "complications", "of", "C0024530#ent", "<e2>", ",", "such", "as", "encephalopathy", "and", "lactic", "acidosis"], "h": {"id": "C0005122", "name": "C0005122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [6, 7]}}
{"token": ["We", "therefore", "estimated", "the", "frequency", "of", "C0005122#ent", "<e1>", "patients", "presenting", "with", "uncomplicated", "falciparum", "C0024530#ent", "<e2>", "in", "southern", "Laos"], "h": {"id": "C0005122", "name": "C0005122#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [13, 14]}}
{"token": ["The", "present", "study", "investigated", "whether", "or", "not", "C1825346#ent", "<e1>", "can", "reduce", "neutrophil-dominant", "inflammation", "in", "airways", "of", "patients", "with", "C0035243#ent", "<e2>"], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", "to", "C1415327#ent", "<e1>", "prions", ",", "the", "301V", ",", "RML", ",", "and", "139A", "C4082486#ent", "<e2>", "strains", "produced", "large", "amounts", "of", "protease-resistant", "PrP(Sc", ")", "in", "the", "brains", "of", "Tg196", "mice", "."], "h": {"id": "C1415327", "name": "C1415327#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [14, 15]}}
{"token": ["Spongiform", "encephalopathies", "as", "scrapie", "in", "sheep", ",", "bovine", "spongiform", "encephalopathy", "BSE", ")", "in", "cattle", "or", "Creutzfeldt-Jacob", "disease", "CJD", ")", "and", "Gerstmann-Str\u00e4ussler-Scheinker", "syndrome", "C1415327#ent", "<e1>", ")", "in", "humans", "is", "caused", "by", "a", "transmissible", "agent", "C4082486#ent", "<e2>", "."], "h": {"id": "C1415327", "name": "C1415327#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [33, 34]}}
{"token": ["Analysis", "of", "deletion", "mutants", "and", "fusions", "of", "C1417846#ent", "<e1>", "to", "the", "C3541252#ent", "<e2>", "DNA", "binding", "domain", "identified", "a", "transcriptional", "activation", "domain", "the", "C", "terminus", "of", "C1417846#ent", "<e1>", "."], "h": {"id": "C1417846", "name": "C1417846#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541252", "name": "C3541252#ent", "pos": [11, 12]}}
{"token": ["We", "diagnosed", "a", "unique", "C0282528#ent", "<e1>", "a", "32-year-old", "man", "with", "profound", "mental", "retardation", "mild", "facial", "dysmorphism", "retinal", "pigmentary", "degeneration", "C0751495#ent", "<e2>", ",", "and", "sensorineural", "deafness"], "h": {"id": "C0282528", "name": "C0282528#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [19, 20]}}
{"token": ["Binding", "to", "C0376944#ent", "<e1>", "DODAB", ")", "or", "distearoyl-sn-glycero-3-phosphocholine", "(", "DSPC", ")", "C0872351#ent", "<e2>", "in", "the", "presence", "of", "calcium", "is", "accompanied", "by", "monolayer", "expansion", "."], "h": {"id": "C0376944", "name": "C0376944#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [11, 12]}}
{"token": ["Binding", "to", "dioctadecyldimethylammonium", "bromide", "C0376944#ent", "<e1>", ")", "or", "distearoyl-sn-glycero-3-phosphocholine", "(", "DSPC", ")", "C0872351#ent", "<e2>", "in", "the", "presence", "of", "calcium", "is", "accompanied", "by", "monolayer", "expansion", "."], "h": {"id": "C0376944", "name": "C0376944#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [12, 13]}}
{"token": ["TPO", "should", "be", "considered", "in", "cases", "where", "C3815497#ent", "<e1>", ",", "dyspnea", ",", "persistent", "pulmonary", "infection", "C0019825#ent", "<e2>", ",", "or", "recurrent", "hemoptysis", "remain", "after", "appropriate", "treatment", "of", "other", "presumptive", "underlying", "causes", "."], "h": {"id": "C3815497", "name": "C3815497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019825", "name": "C0019825#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", "in", "this", "animal", "model", "FeO", "decreases", "rather", "than", "increases", "C0003850#ent", "<e1>", ",", "likely", "because", "C0022092#ent", "<e2>", "a", "hypocholesterolemic", "effect"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022092", "name": "C0022092#ent", "pos": [18, 19]}}
{"token": ["The", "patents", "have", "claims", "regarding", "liquid", "pharmaceutical", "for", "the", "treatment", "of", "C0149931#ent", "<e1>", ",", "which", "contain", "concentrated", "C0012291#ent", "<e2>", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0012291", "name": "C0012291#ent", "pos": [17, 18]}}
{"token": ["C0107454#ent", "<e1>", "had", "a", "C3889265#ent", "<e2>", "of", "8.65", "against", "the", "positive", "chronotropic", "action", "of", "isoproternol", "on", "the", "guinea", "pig", "sinus", "node"], "h": {"id": "C0107454", "name": "C0107454#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889265", "name": "C3889265#ent", "pos": [4, 5]}}
{"token": ["The", "recognition", "that", "the", "prediabetic", "state", "reflects", "a", "postprandial", "disorder", "help", "identify", "people", "with", "C0011849#ent", "<e1>", "and", "reduce", "the", "impact", "of", "C0342257#ent", "<e2>", "cardiovascular", "morbidity", "mortality", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0342257", "name": "C0342257#ent", "pos": [21, 22]}}
{"token": ["Many", "of", "these", "adducts", "form", "rapidly", "during", "C0011849#ent", "<e1>", "and", "promote", "progression", "of", "a", "raft", "of", "C0342257#ent", "<e2>", "complications", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0342257", "name": "C0342257#ent", "pos": [16, 17]}}
{"token": ["All", "interventions", "targeted", "adults", "with", "type", "1", "2", "C0011849#ent", "<e1>", "and", "measured", "C0342257#ent", "<e2>", "complications", "and/or", "surrogate", "outcomes", "of", "hemoglobin", "A1c", "A1C", ")", ",", "blood", "pressure", "or", "lipid", "profiles", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0342257", "name": "C0342257#ent", "pos": [12, 13]}}
{"token": ["Factors", "such", "as", "C0029883#ent", "<e1>", "no", "significant", "effect", "on", "the", "occurrence", "of", "C0030552#ent", "<e2>"], "h": {"id": "C0029883", "name": "C0029883#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [12, 13]}}
{"token": ["C1418873#ent", "<e1>", "also", "interacts", "with", "sigma", ",", "mu", "opioid", "C0026815#ent", "<e2>", ",", "and", "nicotinic", "receptors"], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026815", "name": "C0026815#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "we", "demonstrate", "that", "the", "in", "vivo", "ubiquitination", "of", "members", "of", "the", "Nedd4", "family", "of", "C0023689#ent", "<e1>", "correlates", "with", "their", "ability", "to", "monoubiquitinate", "C1333343#ent", "<e2>", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333343", "name": "C1333343#ent", "pos": [24, 25]}}
{"token": ["The", "results", "suggest", "that", "plasmapheresis", "has", "a", "useful", "place", "in", "the", "treatment", "of", "acute", "and", "rapidly", "progressive", "C0015397#ent", "<e1>", "and", "pretibial", "myxoedema", "patients", "with", "C0023234#ent", "<e2>"], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023234", "name": "C0023234#ent", "pos": [24, 25]}}
{"token": ["C0015397#ent", "<e1>", "an", "extrathyroidal", "tissue-specific", "symptom", "C0023234#ent", "<e2>", "by", "inflammatory", "infiltration", "orbital", "tissues"], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023234", "name": "C0023234#ent", "pos": [6, 7]}}
{"token": ["In", "contrast", ",", "animals", "pretreated", "with", "C1705616#ent", "<e1>", "exhibited", "marked", "LH", "and", "C3273356#ent", "<e2>", "surges", "whether", "treated", "at", "1300", "hr", "proestrus", "with", "C1705616#ent", "<e1>", "or", "vehicle", "."], "h": {"id": "C1705616", "name": "C1705616#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273356", "name": "C3273356#ent", "pos": [12, 13]}}
{"token": ["Effective", "therapy", "for", "severe", "C0024535#ent", "<e1>", "malaria", "can", "be", "provided", "by", "either", "intravenous", "artesunate", "by", "C0025153#ent", "<e2>", "or", "by", "intravenous", "quinine", "followed", "by", "tetracycline", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [4, 5]}, "relation": "may_be_prevented_by", "t": {"id": "C0025153", "name": "C0025153#ent", "pos": [15, 16]}}
{"token": ["C0024535#ent", "<e1>", "malaria", "is", "usually", "treated", "by", "C0025153#ent", "<e2>", ",", "Fansimef", ",", "quinine", "or", "quinidine", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0025153", "name": "C0025153#ent", "pos": [7, 8]}}
{"token": ["Several", "neutrophil", "antigen", "systems", "been", "described", "serologically", ",", "but", "only", "the", "C1414556#ent", "<e1>", "HNA-1", ")", "or", "NA", "and", "C3812693#ent", "<e2>", "or", "NB", "systems", "have", "been", "well", "characterized", "biochemically", "and", "molecularly", "."], "h": {"id": "C1414556", "name": "C1414556#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3812693", "name": "C3812693#ent", "pos": [18, 19]}}
{"token": ["The", "combination", "of", "penicillin", "and", "C0002556#ent", "<e1>", "is", "the", "recommended", "therapy", "C0014122#ent", "<e2>", "caused", "by", "nutritionally", "variant", "streptococci", "NVS", ")", "."], "h": {"id": "C0002556", "name": "C0002556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [11, 12]}}
{"token": ["An", "antiserum", "specific", "for", "human", "cortactin", ",", "showed", "in", "gene", "transfer", "experiments", "that", "both", "human", "p80", "and", "C1423078#ent", "<e1>", "isoforms", "are", "encoded", "by", "the", "C0812261#ent", "<e2>", "cDNA", "."], "h": {"id": "C1423078", "name": "C1423078#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0812261", "name": "C0812261#ent", "pos": [24, 25]}}
{"token": ["C0010674#ent", "<e1>", "patients", "occasionally", "develop", "C0023892#ent", "<e2>", "may", "have", "secondary", "hypersplenism", ",", "varices", ",", "and", "ascites", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0023892", "name": "C0023892#ent", "pos": [5, 6]}}
{"token": ["C0085859#ent", "<e1>", "APECED", ")", "is", "a", "rare", "autosomal", "recessive", "disorder", "by", "C0001403#ent", "<e2>", "hypoparathyroidism", "and/or", "chronic", "mucocutaneous", "candidiasis"], "h": {"id": "C0085859", "name": "C0085859#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "describe", "a", "patient", "with", "C0085859#ent", "<e1>", "the", "endocrine", "manifestations", "of", "hypoparathyroidism", ",", "C0001403#ent", "<e2>", "and", "insulin-dependent", "diabetes", "mellitus"], "h": {"id": "C0085859", "name": "C0085859#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [14, 15]}}
{"token": ["Studies", "in", "mammalian", "cell", "culture", "suggested", "that", "PIE-1", "inhibits", "P-TEFb", ",", "a", "kinase", "that", "phosphorylates", "serine", "2", "the", "C1416810#ent", "<e1>", "CTD", ")", "repeats", "of", "C0035680#ent", "<e2>", "transcriptional", "elongation"], "h": {"id": "C1416810", "name": "C1416810#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [24, 25]}}
{"token": ["C1414121#ent", "<e1>", "immunoreactivity", "correlated", "with", "C1882525#ent", "<e2>", "and", "RASSF2A", "methylation", "(", "p", "<", "0.05", ")", "."], "h": {"id": "C1414121", "name": "C1414121#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1882525", "name": "C1882525#ent", "pos": [5, 6]}}
{"token": ["C1421446#ent", "<e1>", "VEGF-B", ")", "is", "structurally", "closely", "related", "to", "C1522575#ent", "<e2>", "and", "binds", "one", "of", "its", "receptors", ",", "VEGFR-1", "."], "h": {"id": "C1421446", "name": "C1421446#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [9, 10]}}
{"token": ["Previous", "studies", "from", "this", "group", "have", "established", "that", "CI-1023", "can", "successfully", "transfer", "human", "C1421446#ent", "<e1>", "in", "local", "tissue", "expression", "of", "C1522575#ent", "<e2>"], "h": {"id": "C1421446", "name": "C1421446#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [20, 21]}}
{"token": ["We", "have", "isolated", "and", "characterized", "a", "novel", "growth", "factor", "endothelial", "cells", "C1421446#ent", "<e1>", "VEGF-B", ")", ",", "with", "structural", "similarities", "to", "vascular", "endothelial", "growth", "factor", "C1522575#ent", "<e2>", ")", "and", "placenta", "growth", "factor"], "h": {"id": "C1421446", "name": "C1421446#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [24, 25]}}
{"token": ["The", "C1421446#ent", "<e1>", "promoter", "is", "similar", "to", "C1522575#ent", "<e2>", "in", "that", "it", "is", "associated", "with", "CpG", "island", "contains", "sites", "for", "Sp1", "and", "AP-2", ",", "and", "lacks", "a", "TATA", "box"], "h": {"id": "C1421446", "name": "C1421446#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [7, 8]}}
{"token": ["Studies", "of", "an", "inbred", "strain", "mice", "with", "increased", "susceptibility", "to", "mycobacteria", ",", "C0036117#ent", "<e1>", "and", "leishmania", "infections", "to", "the", "identification", "of", "the", "natural", "resistance-associated", "macrophage", "protein", "gene", "C1420088#ent", "<e2>", ")", "."], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420088", "name": "C1420088#ent", "pos": [27, 28]}}
{"token": ["Male", "alcoholics", "often", "suffer", "from", "features", "of", "C0020619#ent", "<e1>", "related", "to", "abnormal", "metabolism", "of", "C0038317#ent", "<e2>"], "h": {"id": "C0020619", "name": "C0020619#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [14, 15]}}
{"token": ["C1706346#ent", "<e1>", "interacts", "with", "retinoic", "acid", "receptor", "C1366536#ent", "<e2>", ")", "and", "retinoid", "X", "receptor", "RXR", ")", "with", "or", "without", "ligands", "."], "h": {"id": "C1706346", "name": "C1706346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [7, 8]}}
{"token": ["Receptor", "interacting", "protein", "140", "C1706346#ent", "<e1>", ")", "interacts", "with", "retinoic", "acid", "receptor", "C1366536#ent", "<e2>", ")", "and", "retinoid", "X", "receptor", "RXR", ")", "constitutively", ",", "but", "hormone", "binding", "this", "interaction", "."], "h": {"id": "C1706346", "name": "C1706346#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "show", "an", "autoregulatory", "loop", "in", "which", "FoxO1a", "directly", "activates", "transcription", "of", "the", "cyclic", "GMP-dependent", "protein", "kinase", "I", "C3489929#ent", "<e1>", ")", "C0079429#ent", "<e2>", "and", "where", "the", "ensuing", "C3489929#ent", "<e1>", "activity", "phosphorylates", "FoxO1a", "and", "abolishes", "its", "DNA", "binding", "activity"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3489929", "name": "C3489929#ent", "pos": [19, 20]}}
{"token": ["Autoimmunity", "to", "structural", "proteins", "collagen", ",", "vimentin", "C1334214#ent", "<e1>", "smooth", "muscle", "antigens", "and", "keratin", "is", "a", "characteristic", "feature", "of", "C0003873#ent", "<e2>", "."], "h": {"id": "C1334214", "name": "C1334214#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["Although", "proton", "magnetic", "resonance", "spectroscopy", "distinguish", "between", "neuronal", "and", "C1136365#ent", "<e1>", "the", "brain", "and", "may", "point", "to", "neurobiological", "mechanisms", "underlying", "C0236642#ent", "<e2>", "cognitive", "changes", "no", "spectroscopic", "studies", "have", "yet", "assessed", "the", "relationships", "between", "adiposity", "and", "brain", "metabolites"], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0236642", "name": "C0236642#ent", "pos": [20, 21]}}
{"token": ["She", "presented", "with", "anorexia", ",", "vomiting", ",", "fatigue", ",", "right", "upper-quadrant", "pain", ",", "C0033775#ent", "<e1>", ",", "darkened", "urine", "and", "jaundice", "after", "about", "two", "weeks", "of", "C0012772#ent", "<e2>", "500", "mg/d", "."], "h": {"id": "C0033775", "name": "C0033775#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012772", "name": "C0012772#ent", "pos": [25, 26]}}
{"token": ["Fructose", "ingestion", "had", "no", "effect", "serum", "ceruloplasmin", "activity", "or", "serum", "copper", "concentration", "but", "did", "significantly", "reduce", "C0669516#ent", "<e1>", "SOD", ")", "activity", "of", "erythrocytes", "as", "compared", "to", "C0054259#ent", "<e2>", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [26, 27]}}
{"token": ["Resorantel", "and", "C0055885#ent", "<e1>", "were", "not", "hydrolysed", "at", "the", "amide", "bond", "helminth", "or", "mammalian", "C3541394#ent", "<e2>", "."], "h": {"id": "C0055885", "name": "C0055885#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [14, 15]}}
{"token": ["C0020625#ent", "<e1>", "and", "MAI", "C0004610#ent", "<e2>", "were", "found", "in", "58", "%", "of", "CMVE", "cases", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [4, 5]}}
{"token": ["ATP-induced", "C0001477#ent", "<e1>", "mobilization", "was", "also", "enhanced", "by", "a", "specific", "C1415545#ent", "<e2>", "GF", "109203X"], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415545", "name": "C1415545#ent", "pos": [10, 11]}}
{"token": ["These", "include", "haematological", "(", "C0023530#ent", "<e1>", "and", "agranulocytosis", ")", ",", "CNS", "(", "C0036572#ent", "<e2>", ")", ",", "cardiovascular", "(", "myocarditis", "and", "cardiomyopathy", ")", ",", "metabolic", "(", "diabetes", ")", ",", "gastrointestinal", "and", "neuromuscular", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}}
{"token": ["Long-term", "treatment", "of", "C0002963#ent", "<e1>", "verapamil", "or", "C0028066#ent", "<e2>", "together", "with", "isosorbide", "dinitrate", "well", "tolerated", "and", "effectively", "relieved", "angina", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [7, 8]}}
{"token": ["Therefore", ",", "the", "present", "study", "was", "performed", "to", "compare", "ergonovine", "responsiveness", "both", "clinical", "and", "ambulatory", "electrocardiographic", "activity", "patients", "with", "C0002963#ent", "<e1>", "long-term", "therapy", "with", "placebo", ",", "verapamil", ",", "and", "C0028066#ent", "<e2>", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [29, 30]}}
{"token": ["The", "degrees", "of", "inhibition", "of", "C0002963#ent", "<e1>", "CD-832", "were", "similar", "to", "those", "produced", "by", "C0028066#ent", "<e2>", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [14, 15]}}
{"token": ["Of", "the", "C0030920#ent", "<e1>", "patients", ",", "87.2", "%", "had", "histological", "evidence", "of", "C0850666#ent", "<e2>"], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0850666", "name": "C0850666#ent", "pos": [12, 13]}}
{"token": ["Although", "C0030920#ent", "<e1>", "recurs", "in", "the", "presence", "of", "C0850666#ent", "<e2>", "the", "effects", "of", "H.", "pylori", "ulcer", "healing", "yet", "to", "be", "studied", "in", "detail", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0850666", "name": "C0850666#ent", "pos": [8, 9]}}
{"token": ["PGF2", "alpha", "production", "in", "amnion", "increased", "significantly", "when", "it", "was", "incubated", "thirty", "minutes", "with", "C1366459#ent", "<e1>", "compared", "to", "that", "incubated", "only", "with", "Hanks", "'", "C1857941#ent", "<e2>", "."], "h": {"id": "C1366459", "name": "C1366459#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1857941", "name": "C1857941#ent", "pos": [24, 25]}}
{"token": ["C1413931#ent", "<e1>", "ACE", ")", "has", "two", "C1334043#ent", "<e2>", "C-terminal", "domains", "displays", "activity", "towards", "a", "broad", "range", "of", "substrates", "."], "h": {"id": "C1413931", "name": "C1413931#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}}
{"token": ["C1413931#ent", "<e1>", "ACE", ",", "CD143", ")", "has", "two", "C1334043#ent", "<e2>", "each", "having", "a", "functional", "active", "site"], "h": {"id": "C1413931", "name": "C1413931#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}}
{"token": ["It", "was", "assumed", "that", "during", "benign", "course", "of", "C0016085#ent", "<e1>", "development", "of", "C0029408#ent", "<e2>", "result", "most", "likely", "due", "to", "reaction", "against", "some", "occult", "agents", "in", "the", "joints", "."], "h": {"id": "C0016085", "name": "C0016085#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [12, 13]}}
{"token": ["TbetaRII", "complex", ",", "disrupted", "by", "C0012789#ent", "<e1>", ",", "or", "direct", "binding", "of", "TGF-beta", "to", "C3540638#ent", "<e2>", "is", "required", "for", "signaling", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540638", "name": "C3540638#ent", "pos": [14, 15]}}
{"token": ["We", "also", "examined", "the", "effects", "of", "C0751039#ent", "<e1>", "on", "infiltration", "and", "C1333196#ent", "<e2>", "expression", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [11, 12]}}
{"token": ["C0751039#ent", "<e1>", "could", "also", "act", "on", "tumor", "necrosis", "factor", "alpha", ",", "a", "C1333196#ent", "<e2>", "which", "is", "important", "in", "TEN", "epidermal", "destruction"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "collagenase", "inhibition", "by", "C1418192#ent", "<e1>", "was", "not", "observed", "in", "an", "assay", "system", "purified", "C0014442#ent", "<e2>", "."], "h": {"id": "C1418192", "name": "C1418192#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["In", "the", "lumenal", "part", "of", "the", "crypt", ",", "up-regulations", "of", "the", "C1667078#ent", "<e1>", "and", "the", "C0085943#ent", "<e2>", "found", "."], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085943", "name": "C0085943#ent", "pos": [15, 16]}}
{"token": ["These", "data", "indicate", "that", "a", "change", "of", "C0012863#ent", "<e1>", "binding", "to", "critical", "regulatory", "region", "the", "C0079068#ent", "<e2>", "associated", "with", "downregulation", "of", "this", "gene", "during", "differentiation", "."], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [15, 16]}}
{"token": ["Topo", "II", "mRNA", "levels", "were", "associated", "with", "C0012863#ent", "<e1>", "activity", "in", "cell", "lines", "increased", "with", "C0079068#ent", "<e2>", "cleavage", "."], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [15, 16]}}
{"token": ["HIV", "Vif", "counters", "the", "effect", "of", "C1143167#ent", "<e1>", "depleting", "intracellular", "stores", "of", "the", "C0014442#ent", "<e2>", ",", "thereby", "blocking", "its", "virion", "incorporation", "."], "h": {"id": "C1143167", "name": "C1143167#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["When", "ear", "arteries", "exposed", "to", "C2987634#ent", "<e1>", "in", "the", "presence", "of", "C1414404#ent", "<e2>", "or", "papaverine", "the", "increase", "in", "responsiveness", "was", "either", "reduced", "or", "absent", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414404", "name": "C1414404#ent", "pos": [11, 12]}}
{"token": ["C0039857#ent", "<e1>", ",", "although", "exhibiting", "high", "affinity", "for", "muscarinic", "receptors", "C3889265#ent", "<e2>", "=", "7.83", "-", "8.51", ")", ",", "was", "found", "to", "be", "non-selective", "."], "h": {"id": "C0039857", "name": "C0039857#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889265", "name": "C3889265#ent", "pos": [10, 11]}}
{"token": ["A", "case", "of", "extremely", "C0030193#ent", "<e1>", "swelling", "of", "the", "C0024902#ent", "<e2>", "following", "a", "reduction", "mammaplasty", "is", "presented", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0024902", "name": "C0024902#ent", "pos": [9, 10]}}
{"token": ["We", "represent", "the", "case", "of", "premenarchal", "14", "year", "old", "girl", "complaining", "of", "a", "four", "month", "history", "of", "C0030193#ent", "<e1>", "enlargement", "of", "both", "C0024902#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0024902", "name": "C0024902#ent", "pos": [22, 23]}}
{"token": ["Women", "with", "intermittent", "C0030193#ent", "<e1>", "in", "the", "breast", "differed", "statistically", "significantly", "other", "women", "without", "C0024902#ent", "<e2>", "in", "8", "out", "of", "12", "personality", "characteristics", "(", "FPI", ")", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0024902", "name": "C0024902#ent", "pos": [14, 15]}}
{"token": ["Both", "young", "women", "were", "referred", "to", "Mulago", "Hospital", ",", "Department", "of", "Radiology", "breast", "imaging", "of", "C0030193#ent", "<e1>", "enlargement", "of", "both", "C0024902#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0024902", "name": "C0024902#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "we", "report", "that", "C1824367#ent", "<e1>", "is", "bound", "by", "C1538607#ent", "<e2>", "both", "in", "vitro", "in", "vivo", "a", "similar", "mechanism", "by", "which", "C1538607#ent", "<e2>", "binds", "calreticulin", "."], "h": {"id": "C1824367", "name": "C1824367#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538607", "name": "C1538607#ent", "pos": [11, 12]}}
{"token": ["The", "toxicity", "of", "these", "compounds", "was", "decreased", "by", "adding", "the", "C0020364#ent", "<e1>", "MFOS", ")", "inhibitor", ",", "C0618948#ent", "<e2>", "(", "25", "microM", ")", "to", "the", "cultures", "."], "h": {"id": "C0020364", "name": "C0020364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0618948", "name": "C0618948#ent", "pos": [16, 17]}}
{"token": ["C0020364#ent", "<e1>", "activity", "could", "be", "inhibited", "by", "carbon", "monoxide", "C0618948#ent", "<e2>", ",", "and", "by", "specific", "inhibitors", "of", "microsomal", "benzene", "metabolism"], "h": {"id": "C0020364", "name": "C0020364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0618948", "name": "C0618948#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "in", "C0023890#ent", "<e1>", "fibrin", "formation", "is", "altered", "because", "of", "C0015526#ent", "<e2>", "but", "a", "normal", "fibrinogen", "synthesized", "by", "the", "liver", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015526", "name": "C0015526#ent", "pos": [11, 12]}}
{"token": ["These", "data", "agree", "with", "the", "notion", "that", "hereditary", "thrombophilia", "associated", "with", "C0242666#ent", "<e1>", "indeed", "directly", "the", "result", "of", "a", "defect", "in", "the", "C2002622#ent", "<e2>"], "h": {"id": "C0242666", "name": "C0242666#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2002622", "name": "C2002622#ent", "pos": [22, 23]}}
{"token": ["Cross-reactivities", "were", ",", "however", ",", "observed", "with", "sera", "from", "patients", "with", "other", "C0026946#ent", "<e1>", "such", "as", "histoplasmosis", ",", "lobomycosis", ",", "C0010414#ent", "<e2>", ",", "candidiasis", ",", "and", "sporotrichosis", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0010414", "name": "C0010414#ent", "pos": [20, 21]}}
{"token": ["The", "cases", "of", "four", "other", "patients", "with", "chronic", "mucocutaneous", "candidiasis", "invasive", "C0026946#ent", "<e1>", "three", "with", "C0010414#ent", "<e2>", "and", "one", "with", "histoplasmosis", ",", "have", "been", "reported", "previously", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0010414", "name": "C0010414#ent", "pos": [15, 16]}}
{"token": ["The", "phosphorylation", "of", "C1413277#ent", "<e1>", "occurs", "in", "an", "age-", "and", "C1420295#ent", "<e2>", "pattern", "during", "development", "in", "the", "neural", "retina", "brain", ",", "lens", "and", "heart", "."], "h": {"id": "C1413277", "name": "C1413277#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [10, 11]}}
{"token": ["C1337105#ent", "<e1>", "was", "then", "fully", "degraded", "to", "C0067320#ent", "<e2>", "and", "carbon", "dioxide", "acetate", "."], "h": {"id": "C1337105", "name": "C1337105#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0067320", "name": "C0067320#ent", "pos": [7, 8]}}
{"token": ["It", "is", "suggested", "that", "C1161331#ent", "<e1>", "facilitates", "the", "gene", "expression", "C1708296#ent", "<e2>", "and", "HSP70", "in", "brain", "after", "restraint", "stress", "which", "may", "attenuate", "stress", "."], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1708296", "name": "C1708296#ent", "pos": [10, 11]}}
{"token": ["Several", "patients", "developed", "C3266262#ent", "<e1>", "probably", "with", "C0019189#ent", "<e2>", "pivot", "."], "h": {"id": "C3266262", "name": "C3266262#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019189", "name": "C0019189#ent", "pos": [7, 8]}}
{"token": ["MBD3L2", "(", "methyl-CpG-binding", "protein", "3-like", "2", "is", "a", "protein", "with", "substantial", "homology", "to", "MBD2", "and", "C1417051#ent", "<e1>", ",", "but", "it", "lacks", "the", "C2986645#ent", "<e2>"], "h": {"id": "C1417051", "name": "C1417051#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2986645", "name": "C2986645#ent", "pos": [22, 23]}}
{"token": ["All", "16", "dbpB", "(", "C2985446#ent", "<e1>", ")", "clones", ",", "isolated", "from", "the", "same", "genomic", "library", "for", "C1413746#ent", "<e2>", "genomic", "cloning", "were", "processed", "genes", "because", "of", "their", "intronless", "structures", "and", "multiple", "mutations"], "h": {"id": "C2985446", "name": "C2985446#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413746", "name": "C1413746#ent", "pos": [16, 17]}}
{"token": ["Among", "the", "variant", "antigens", "CSF", "reactivity", "was", "mainly", "with", "the", "C2985446#ent", "<e1>", "from", "B.", "garinii", ",", "whereas", "positivity", "with", "the", "C1413746#ent", "<e2>", "from", "B.", "afzelii", "or", "B.", "garinii", "predominated", "."], "h": {"id": "C2985446", "name": "C2985446#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413746", "name": "C1413746#ent", "pos": [20, 21]}}
{"token": ["The", "minichromosome", "maintenance", "protein", "complex", "(", "MCM", ")", "and", "C1705434#ent", "<e1>", "have", "now", "been", "recognized", "as", "C1136365#ent", "<e2>", "the", "initiation", "machinery", "."], "h": {"id": "C1705434", "name": "C1705434#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [16, 17]}}
{"token": ["With", "the", "objective", "of", "exploring", "the", "significance", "of", "that", "association", ",", "the", "present", "paper", "offers", "an", "analysis", "of", "the", "linkage", "disequilibrium", "C0002085#ent", "<e1>", "haplotypes", "and", "the", "C3469186#ent", "<e2>", "mutations", "in", "a", "Portuguese", "population"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3469186", "name": "C3469186#ent", "pos": [26, 27]}}
{"token": ["The", "C0002085#ent", "<e1>", "frequencies", "of", "the", "C3469186#ent", "<e2>", "mutations", "(", "0.017", "for", "C282Y", "mutation", "and", "0.124", "for", "H63D", "mutation", ")", "did", "not", "differ", "between", "patients", "with", "CRI", "and", "healthy", "controls"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3469186", "name": "C3469186#ent", "pos": [6, 7]}}
{"token": ["C0002085#ent", "<e1>", "and", "haplotype", "associations", "between", "HLA", "and", "C3469186#ent", "<e2>", "mutations", "were", "first", "reviewed", "in", "a", "population", "of", "43", "hemochromatosis", "families", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3469186", "name": "C3469186#ent", "pos": [8, 9]}}
{"token": ["C0151517#ent", "<e1>", "is", "accompanied", "by", "ECG", "abnormalities", "C0004245#ent", "<e2>", "sinus", "bradycardia", "and", "ventricular", "dysfunction"], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004245", "name": "C0004245#ent", "pos": [7, 8]}}
{"token": ["Although", "the", "hallmark", "of", "C0151517#ent", "<e1>", "is", "complete", "C0004245#ent", "<e2>", "sinus", "bradycardia", "been", "reported", "recently", "in", "animal", "models", "C0151517#ent", "<e1>", "."], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004245", "name": "C0004245#ent", "pos": [8, 9]}}
{"token": ["Congenital", "heart", "block", "C0151517#ent", "<e1>", ")", "is", "a", "conduction", "abnormality", "characterized", "by", "complete", "C0004245#ent", "<e2>"], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004245", "name": "C0004245#ent", "pos": [13, 14]}}
{"token": ["In", "fact", "C1172090#ent", "<e1>", "is", "the", "C0031727#ent", "<e2>", "of", "the", "P-TEFb", "complex", "involved", "in", "basal", "transcription"], "h": {"id": "C1172090", "name": "C1172090#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}}
{"token": ["The", "relationship", "between", "CCR5", "and", "C1413188#ent", "<e1>", "genotypes", "and", "C3854222#ent", "<e2>", "disease", "progression", "studied", "among", "the", "108", "seroconverters", "of", "the", "Amsterdam", "cohort", "injecting", "drug", "users", "(", "IDUs", ")", "."], "h": {"id": "C1413188", "name": "C1413188#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [9, 10]}}
{"token": ["A", "polymorphism", "in", "the", "gene", "encoding", "C1413188#ent", "<e1>", "is", "associated", "with", "delay", "in", "progression", "to", "AIDS", "in", "C3854222#ent", "<e2>", "individuals", "."], "h": {"id": "C1413188", "name": "C1413188#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [17, 18]}}
{"token": ["Serum", "precipitins", "an", "antigen", "(", "or", "antigens", ")", "in", "the", "C0023899#ent", "<e1>", "in", "the", "IgA", "and", "C1706005#ent", "<e2>", "classes", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [16, 17]}}
{"token": ["We", "found", "22", "patients", "who", "received", "C1176309#ent", "<e1>", "retreatment", "following", "a", "60", "or", "more", "day", "C2984552#ent", "<e2>", "between", "C1176309#ent", "<e1>", "treatments", "."], "h": {"id": "C1176309", "name": "C1176309#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2984552", "name": "C2984552#ent", "pos": [15, 16]}}
{"token": ["Accordingly", ",", "overexpression", "of", "C1416710#ent", "<e1>", "in", "an", "erythroblast", "cell", "line", "down-regulates", "the", "endogenous", "C1420707#ent", "<e2>", "inhibits", "differentiation", "without", "affecting", "cell", "proliferation"], "h": {"id": "C1416710", "name": "C1416710#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420707", "name": "C1420707#ent", "pos": [14, 15]}}
{"token": ["Endothelial", "cell", "permeabilized", "with", "saponin", "retract", "upon", "exposure", "to", "C0082645#ent", "<e1>", "or", "trypsin-activated", "gamma-PAK", "and", "C1705556#ent", "<e2>", "."], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [15, 16]}}
{"token": ["Indeed", ",", "the", "validity", "of", "both", "C0267805#ent", "<e1>", "the", "\"", "transient", "stomatocytosis", "hemolysis", "\"", "C0039082#ent", "<e2>", "is", "questioned", "."], "h": {"id": "C0267805", "name": "C0267805#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}}
{"token": ["In", "the", "treatment", "of", "C0003850#ent", "<e1>", "for", "the", "selective", "C1414262#ent", "<e2>", "blocker", "reduction", "of", "the", "number", "and", "size", "of", "macrophage", "and", "foam", "cells", "proved", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414262", "name": "C1414262#ent", "pos": [9, 10]}}
{"token": ["Kinetic", "analysis", "C1706333#ent", "<e1>", "showed", "no", "differences", "in", "Km", "for", "lipoamide", "between", "C1856689#ent", "<e2>", "patients", "and", "controls", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1856689", "name": "C1856689#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "higenamine", ",", "a", "C0259969#ent", "<e1>", "on", "induction", "of", "C1705516#ent", "<e2>", "by", "bacterial", "lipopolysaccharide", "LPS", ")", "were", "examined", "in", "murine", "peritoneal", "macrophages"], "h": {"id": "C0259969", "name": "C0259969#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705516", "name": "C1705516#ent", "pos": [11, 12]}}
{"token": ["We", "previously", "reported", "that", "the", "levels", "of", "C1706005#ent", "<e1>", "and", "the", "incidence", "of", "C1861821#ent", "<e2>", "were", "elevated", "in", "preterm", "infants", "neonatal", "pulmonary", "emphysema"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1861821", "name": "C1861821#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "many", "workers", "in", "the", "developing", "countries", "from", "poor", "nutrition", "C0277550#ent", "<e1>", "and", "other", "C3714552#ent", "<e2>", "conditions", "."], "h": {"id": "C0277550", "name": "C0277550#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [15, 16]}}
{"token": ["Such", "a", "coupling", "could", "account", "for", "increased", "blood-brain", "neutral", "amino", "acid", "in", "C0023895#ent", "<e1>", "decreased", "transport", "activity", "treatment", "with", "methionine", "sulfoximine", "a", "C0017801#ent", "<e2>"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017801", "name": "C0017801#ent", "pos": [22, 23]}}
{"token": ["RT-PCR", "confirmed", "mRNA", "expression", "of", "AC2", ",", "AC3", ",", "AC5", ",", "and", "C1412225#ent", "<e1>", "and", "demonstrated", "C1412226#ent", "<e2>", "and", "AC8", "transcripts", "in", "smooth", "muscle"], "h": {"id": "C1412225", "name": "C1412225#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412226", "name": "C1412226#ent", "pos": [16, 17]}}
{"token": ["The", "cause", "of", "the", "C0037061#ent", "<e1>", "iron", "overload", "is", "common", "in", "C0162566#ent", "<e2>", "PCT", ")", "is", "uncertain", "."], "h": {"id": "C0037061", "name": "C0037061#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "indicate", "that", "HLA-linked", "hemochromatosis", "alleles", "are", "far", "more", "common", "in", "patients", "with", "C0162566#ent", "<e1>", "in", "individuals", "in", "the", "general", "population", "may", "be", "responsible", "for", "the", "C0037061#ent", "<e2>", "associated", "with", "cases", "of", "C0162566#ent", "<e1>"], "h": {"id": "C0037061", "name": "C0037061#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "the", "association", "between", "urinary", "1-OHPG", "and", "C3495801#ent", "<e1>", "mutation", "might", "be", "modulated", "by", "the", "C0919534#ent", "<e2>", "genotype", "."], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0919534", "name": "C0919534#ent", "pos": [18, 19]}}
{"token": ["The", "IC50", "determined", "for", "monomeric", "IgG", "was", "10", "microM", ",", "demonstrating", "a", "relative", "specificity", "of", "C1420017#ent", "<e1>", "binding", "for", "C1417239#ent", "<e2>", "."], "h": {"id": "C1420017", "name": "C1420017#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417239", "name": "C1417239#ent", "pos": [19, 20]}}
{"token": ["Despite", "relatively", "C0304516#ent", "<e1>", "uptake", "of", "C0136123#ent", "<e2>", ",", "both", "drugs", "had", "similar", "effects", "on", "the", "cardiac", "metabolism", "angiotensin", "and", "bradykinin", "and", "on", "cardiac", "function"], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0136123", "name": "C0136123#ent", "pos": [6, 7]}}
{"token": ["Moreover", ",", "binding", "profiles", "both", "enzymes", "to", "C2350558#ent", "<e1>", "PK", "were", "altered", "by", "excess", "amount", "of", "C2698697#ent", "<e2>", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2698697", "name": "C2698697#ent", "pos": [16, 17]}}
{"token": ["C0066646#ent", "<e1>", "treatment", "increased", "the", "weight", "gain", "cattle", "infested", "with", "C0013578#ent", "<e2>", "."], "h": {"id": "C0066646", "name": "C0066646#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013578", "name": "C0013578#ent", "pos": [10, 11]}}
{"token": ["C0055461#ent", "<e1>", "(", "250", "mg", ")", "given", "2", "h", "before", "C0003420#ent", "<e2>", "(", "600", "mg", "orally", ")", "had", "no", "effect", "salivary", "kinetics", "of", "C0003420#ent", "<e2>", "or", "on", "the", "urinary", "recovery", "metabolites", "."], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003420", "name": "C0003420#ent", "pos": [10, 11]}}
{"token": ["Activation", "of", "the", "PKA", "and", "PKC", "pathways", "by", "10", "microM", "C0917964#ent", "<e1>", "and", "1", "microM", "PMA", ",", "respectively", ",", "induced", "C1427858#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1427858", "name": "C1427858#ent", "pos": [20, 21]}}
{"token": ["The", "Mr", "congruent", "to", "230,000", "C0030956#ent", "<e1>", "is", "not", "the", "alpha", "or", "beta", "subunit", "spectrin", "or", "C1412402#ent", "<e2>", "and", "appears", "not", "to", "have", "been", "recognized", "previously", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412402", "name": "C1412402#ent", "pos": [16, 17]}}
{"token": ["Fusion", "C0030956#ent", "<e1>", "of", "glutathione", "S-transferase", "these", "25", "amino", "acids", "bind", "specifically", "to", "C1412402#ent", "<e2>", "Kd", "=", "118", "+", "/-", "50", "nM", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412402", "name": "C1412402#ent", "pos": [13, 14]}}
{"token": ["During", "childhood", ",", "the", "kidney", "may", "be", "involved", "in", "several", "different", "systemic", "diseases", "the", "vasculitic", "syndromes", "C0262428#ent", "<e1>", "and", "the", "C2717961#ent", "<e2>"], "h": {"id": "C0262428", "name": "C0262428#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [20, 21]}}
{"token": ["Alterations", "in", "the", "Ras-PI3K-Akt", "signal", "transduction", "pathway", "can", "result", "in", "induction", "of", "C0019475#ent", "<e1>", "its", "attachment", "to", "mitochondrial", "porin", "C0949692#ent", "<e2>", "phosphorylate", "glucose", "and", "drive", "glycolysis", "."], "h": {"id": "C0019475", "name": "C0019475#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0949692", "name": "C0949692#ent", "pos": [19, 20]}}
{"token": ["Use", "of", "C0086268#ent", "<e1>", "(", "disodium", "ethane", "1-hydroxy", ",", "C0012544#ent", "<e2>", ",", "or", "disodium", "etidronate", "is", "not", "as", "yet", "of", "proved", "value", "in", "most", "patients", "."], "h": {"id": "C0086268", "name": "C0086268#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "intravenous", "diphosphonates", "C0086268#ent", "<e1>", ",", "clodronate", "and", "C0012544#ent", "<e2>", "on", "phosphate", "homoeostasis", "studied", "in", "30", "patients", "with", "Paget's", "disease", "bone", "and", "in", "three", "patients", "with", "hypoparathyroidism", "."], "h": {"id": "C0086268", "name": "C0086268#ent", "pos": [5, 6]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [10, 11]}}
{"token": ["Using", "C2984024#ent", "<e1>", "(", "flow", "cytometry", ",", "we", "analyzed", "the", "ErbB-2", "(", "C0242957#ent", "<e2>", "status", "of", "61", "breast", "cancer", "tissue", "samples", "by", "FNAB", "(", "fine-needle", "aspiration", "biopsy", "."], "h": {"id": "C2984024", "name": "C2984024#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [12, 13]}}
{"token": ["Because", "of", "their", "C0812382#ent", "<e1>", "selectivity", "and", "modular", "organization", "arrays", "of", "zinc", "finger", "C1824789#ent", "<e2>", ")", "domains", "have", "traditionally", "been", "used", "to", "build", "the", "ATF", "'s", "DNA-binding", "domains"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1824789", "name": "C1824789#ent", "pos": [13, 14]}}
{"token": ["CV", "convert", "C0114832#ent", "<e1>", "preferentially", "to", "5,6-dihydroxy-indole-2-carboxylic", "acid", "DHI2C", ")", "and", "C0033046#ent", "<e2>", "mainly", "to", "5,6-dihydroxyindole", "(", "DHI", ")", "."], "h": {"id": "C0114832", "name": "C0114832#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033046", "name": "C0033046#ent", "pos": [11, 12]}}
{"token": ["Unlike", "wild-type", "C1336608#ent", "<e1>", "or", "PSF", ",", "which", "are", "nuclear", "proteins", "C3274865#ent", "<e2>", "is", "not", "a", "nuclear", "protein", "is", "targeted", "to", "the", "endosomal", "compartment"], "h": {"id": "C1336608", "name": "C1336608#ent", "pos": [2, 3]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274865", "name": "C3274865#ent", "pos": [11, 12]}}
{"token": ["Autopsy", "revealed", "advanced", "C0268731#ent", "<e1>", "codeposition", "of", "delta", "heavy", "C0314619#ent", "<e2>"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0314619", "name": "C0314619#ent", "pos": [9, 10]}}
{"token": ["A", "repeat", "renal", "biopsy", "deposits", "composed", "of", "immunoglobulin", "G", "IgG", ")", "heavy", "chain", "complement", "components", "C3", "C0268731#ent", "<e1>", "tubular", ",", "and", "vascular", "basement", "membranes", "with", "negativity", "for", "kappa", "and", "C0314619#ent", "<e2>", "findings", "consistent", "with", "heavy", "chain", "deposition", "disease", "HCDD", ")", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0314619", "name": "C0314619#ent", "pos": [29, 30]}}
{"token": ["The", "C0268731#ent", "<e1>", "of", "42", "renal", "biopsies", "were", "strongly", "positive", "for", "C0314619#ent", "<e2>", "while", "only", "25", "specimens", "were", "positive", "for", "kappa", "light", "chain"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0314619", "name": "C0314619#ent", "pos": [11, 12]}}
{"token": ["The", "cDNA", "predicts", "an", "C1412821#ent", "<e1>", "encoding", "a", "C3539619#ent", "<e2>", "341", "amino", "acids", "a", "12-amino", "acid", "cytoplasmic", "domain", "a", "311-amino", "acid", "luminal", "domain", "containing", "a", "single", "potential", "N-linked", "glycosylation", "site", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539619", "name": "C3539619#ent", "pos": [8, 9]}}
{"token": ["The", "predicted", "C1412821#ent", "<e1>", "encodes", "a", "typical", "C3539619#ent", "<e2>", "543", "amino", "acids", "the", "sequence", "of", "which", "was", "highly", "homologous", "to", "chondroitin", "sulfate", "N-acetylgalactosaminyltransferase", "CSGalNAcT-1", ")", ",", "and", "we", "designated", "this", "novel", "enzyme", "CSGalNAcT-2", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539619", "name": "C3539619#ent", "pos": [7, 8]}}
{"token": ["The", "cDNA", "predicts", "an", "C1412821#ent", "<e1>", "encoding", "a", "C3539619#ent", "<e2>", "376", "amino", "acids", "a", "43-amino", "acid", "cytoplasmic", "domain", "a", "316-amino", "acid", "luminal", "domain", "containing", "two", "potential", "N-linked", "glycosylation", "sites", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539619", "name": "C3539619#ent", "pos": [8, 9]}}
{"token": ["Short-term", "consumption", "of", "C4283784#ent", "<e1>", "does", "not", "seem", "to", "exhibit", "C0016018#ent", "<e2>", "humans", "."], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [10, 11]}}
{"token": ["The", "target", "of", "the", "presently", "available", "inhibitors", "is", "the", "C4283742#ent", "<e1>", "GCS", ")", ",", "but", "effects", "on", "C3541394#ent", "<e2>", "from", "other", "organisms", "have", "not", "been", "studied", "."], "h": {"id": "C4283742", "name": "C4283742#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["This", "study", "shows", "that", "both", "RCs", "and", "C4283742#ent", "<e1>", "produce", "stromelysin-1", "and", "72", "kDa", "gelatinase", "and", "that", "these", "C3541394#ent", "<e2>", "are", "preferentially", "localized", "in", "MVs", "."], "h": {"id": "C4283742", "name": "C4283742#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}}
{"token": ["These", "results", "indicate", "that", "C2757070#ent", "<e1>", "could", "induce", "C1413179#ent", "<e2>", "expression", "in", "the", "primary", "culture", "mouse", "endometrial", "epithelial", "cells", ",", "meanwhile", "inhibit", "the", "proliferation", "of", "cells", "and", "block", "the", "cell", "cycle", "progression", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413179", "name": "C1413179#ent", "pos": [8, 9]}}
{"token": ["The", "combination", "of", "C0012373#ent", "<e1>", "and", "propranolol", "similarly", "resulted", "in", "C0018802#ent", "<e2>", "one", "patient", "who", "had", "tolerated", "both", "drugs", "alone", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}}
{"token": ["A", "clue", "to", "the", "problem", "with", "the", "calcium", "antagonists", "provided", "by", "the", "C0012373#ent", "<e1>", "in", "which", "an", "adverse", "effect", "the", "presence", "of", "C0018802#ent", "<e2>", "a", "benefit", "in", "those", "without", "heart", "failure"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [22, 23]}}
{"token": ["The", "Multicenter", "Diltiazem", "Postinfarction", "Trial", "(", "MDPIT", ")", "reported", "no", "consistent", "C0012373#ent", "<e1>", "effect", "on", "new", "or", "worsened", "congestive", "heart", "failure", "C0018802#ent", "<e2>", ")", "during", "12", "-", "52", "months", "'", "follow-up", "after", "acute", "myocardial", "infarction"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["In", "the", "placentas", "from", "smokers", ",", "both", "types", "of", "C0608437#ent", "<e1>", "contribute", "to", "C1705135#ent", "<e2>", "activity", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705135", "name": "C1705135#ent", "pos": [13, 14]}}
{"token": ["However", ",", "despite", "differential", "effects", "of", "liver", "disorders", "C0608437#ent", "<e1>", "and", "AHH", "and", "C1705135#ent", "<e2>", "activities", "there", "were", "highly", "significant", "correlations", "between", "these", "three", "parameters", "with", "each", "other", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705135", "name": "C1705135#ent", "pos": [13, 14]}}
{"token": ["The", "close", "relationship", "between", "the", "C0002085#ent", "<e1>", "for", "the", "C0052080#ent", "<e2>", "cross-reacting", "group", "was", "supported", "by", "a", "phylogenetic", "tree", "analysis", "the", "HLA-A", "alleles"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0052080", "name": "C0052080#ent", "pos": [9, 10]}}
{"token": ["Co-amplification", "of", "three", "C0002085#ent", "<e1>", "of", "HLA-H", "pseudogene", "apparent", "linkage", "disequilibrium", "HLA-A2", "and", "C0052080#ent", "<e2>", "was", "observed", "but", "did", "not", "interfere", "with", "the", "typing", "of", "HLA-A", "alleles"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0052080", "name": "C0052080#ent", "pos": [13, 14]}}
{"token": ["The", "model", "system", "composed", "of", "a", "well-characterized", "C0014432#ent", "<e1>", "namely", "bovine", "carbonic", "anhydrase", "II", "CA", "II", "and", "4-carboxybenzenesulfonamide", "(", "C1439329#ent", "<e2>", ")", "."], "h": {"id": "C0014432", "name": "C0014432#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1439329", "name": "C1439329#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", "we", "wished", "to", "determine", "whether", "C1416670#ent", "<e1>", "and/or", "other", "KLK", "C1417679#ent", "<e2>", "were", "expressed", "in", "human", "pituitary", "tumours"], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "present", "a", "1.5", "A-resolution", "structure", "of", "two", "copies", "of", "the", "DBD", "of", "human", "C1419359#ent", "<e1>", "(", "hRFX1", ")", "binding", "cooperatively", "to", "a", "symmetrical", "C1421527#ent", "<e2>", "."], "h": {"id": "C1419359", "name": "C1419359#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1421527", "name": "C1421527#ent", "pos": [25, 26]}}
{"token": ["C1419359#ent", "<e1>", ",", "the", "first", "C1421527#ent", "<e2>", ",", "encodes", "a", "functionally", "relevant", "factor", "present", "in", "complex", "A", "and", "not", "in", "complex", "B", "originally", "suspected", "."], "h": {"id": "C1419359", "name": "C1419359#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421527", "name": "C1421527#ent", "pos": [5, 6]}}
{"token": ["The", "incidence", "of", "non-A", ",", "C0019196#ent", "<e1>", "as", "estimated", "by", "unexplained", "elevations", "in", "serum", "aspartate", "aminotransferase", "C0004002#ent", "<e2>", ")", "values", ",", "was", "not", "different", "between", "patients", "receiving", "and", "not", "receiving", "blood", "transfusions"], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004002", "name": "C0004002#ent", "pos": [16, 17]}}
{"token": ["This", "cytokine", "release", "could", "be", "blocked", "by", "C0002502#ent", "<e1>", ",", "a", "pH", "receptor", "antagonist", "but", "not", "by", "C0008286#ent", "<e2>", "."], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "ethacrynic", "acid", "C0002502#ent", "<e1>", ",", "ouabain", ",", "oestrogens", "and", "C0008286#ent", "<e2>", "are", "among", "those", "agents", "which", "decrease", "bile", "flow"], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [12, 13]}}
{"token": ["Two", "patients", "required", "adrenocorticosteroids", "to", "control", "severe", "C0034153#ent", "<e1>", "the", "period", "of", "C3831153#ent", "<e2>", ",", "after", "which", "complete", "remission", "occurred", "."], "h": {"id": "C0034153", "name": "C0034153#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [12, 13]}}
{"token": ["We", "sought", "to", "determine", "whether", "C0001644#ent", "<e1>", "the", "brain", "extraction", "L-dopa", "and", "C0281255#ent", "<e2>", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0281255", "name": "C0281255#ent", "pos": [12, 13]}}
{"token": ["Thus", "the", "effects", "of", "C0014025#ent", "<e1>", "are", "variable", "and", "this", "may", "have", "important", "implications", "when", "C0014025#ent", "<e1>", "is", "used", "to", "treat", "C0018801#ent", "<e1>", "patients", "with", "underlying", "severe", "ischaemic", "heart", "disease"], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [21, 22]}}
{"token": ["The", "new", ",", "long", "acting", "converting", "enzyme", "inhibitor", "C0014025#ent", "<e1>", "was", "given", "to", "26", "patients", "with", "moderate", "to", "severe", "C0018801#ent", "<e2>"], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["The", "use", "of", "loratadine", "was", "compared", "to", "C0137440#ent", "<e1>", "in", "the", "treatment", "of", "children", "affected", "by", "C0035457#ent", "<e2>", "order", "to", "assess", "its", "clinical", "efficacy", "tolerability", "."], "h": {"id": "C0137440", "name": "C0137440#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [16, 17]}}
{"token": ["Other", "localization", "reported", "in", "other", "countries", ",", "for", "example", ":", "olecranon", "bursitis", "skin", "infections", "C0024205#ent", "<e1>", "osteomyelitis", "and", "C0022658#ent", "<e2>", "not", "reported", "in", "our", "country", "up", "to", "now", "."], "h": {"id": "C0024205", "name": "C0024205#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [18, 19]}}
{"token": ["More", "than", "2000", "C0033860#ent", "<e1>", "patients", "have", "been", "treated", "with", "C0962603#ent", "<e2>", "in", "clinical", "trials"], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0962603", "name": "C0962603#ent", "pos": [10, 11]}}
{"token": ["We", "reported", "a", "14-year-old", "female", "with", "C4281785#ent", "<e1>", "suffered", "from", "pure", "red", "cell", "aplasia", "weeks", "after", "sodium", "valproate", "C0042291#ent", "<e2>", ")", "therapy", "started", "."], "h": {"id": "C4281785", "name": "C4281785#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [18, 19]}}
{"token": ["HBx", "activation", "of", "JNK", "and", "sustained", "activation", "of", "C0162508#ent", "<e1>", ",", "should", "they", "occur", "in", "the", "context", "of", "C4288963#ent", "<e2>", "might", "play", "a", "role", "in", "viral", "transformation", "pathogenesis", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4288963", "name": "C4288963#ent", "pos": [18, 19]}}
{"token": ["C1420089#ent", "<e1>", "DMT1", ")", "is", "a", "C1415205#ent", "<e2>", "mediates", "the", "proton-coupled", "transport", "a", "variety", "of", "divalent", "metal", "ions", "."], "h": {"id": "C1420089", "name": "C1420089#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415205", "name": "C1415205#ent", "pos": [6, 7]}}
{"token": ["Divalent", "metal", "transporter", "1", "C1420089#ent", "<e1>", ")", "is", "a", "C1415205#ent", "<e2>", "mediates", "the", "proton-coupled", "transport", "a", "variety", "of", "divalent", "metal", "ions", "."], "h": {"id": "C1420089", "name": "C1420089#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415205", "name": "C1415205#ent", "pos": [9, 10]}}
{"token": ["A", "family", "with", "a", "possible", "recombination", "between", "the", "21-hydroxylase", "deficiency", "the", "C1334545#ent", "<e1>", "found", ",", "thus", "indicating", "that", "the", "C1413861#ent", "<e2>", "outside", "the", "HLA", "system", "is", "closely", "linked", "to", "the", "HLA-DR", "locus", "."], "h": {"id": "C1334545", "name": "C1334545#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413861", "name": "C1413861#ent", "pos": [19, 20]}}
{"token": ["Further", "investigation", "of", "C0064113#ent", "<e1>", "as", "a", "therapeutic", "agent", "C0041234#ent", "<e2>", "be", "warranted", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041234", "name": "C0041234#ent", "pos": [9, 10]}}
{"token": ["The", "results", "show", "that", "C1425563#ent", "<e1>", "differs", "from", "other", "members", "of", "the", "C1425563#ent", "<e1>", "family", "in", "expression", "and", "function", ",", "suggesting", "other", "roles", "in", "maleness", "."], "h": {"id": "C1425563", "name": "C1425563#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425563", "name": "C1425563#ent", "pos": [4, 5]}}
{"token": ["The", "RT-PCR", "analysis", "the", "C1425563#ent", "<e1>", "family", "revealed", "that", "C1425563#ent", "<e1>", "was", "expressed", "in", "all", "13", "tissues", "examined", "but", "not", "in", "leukocytes", "."], "h": {"id": "C1425563", "name": "C1425563#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425563", "name": "C1425563#ent", "pos": [4, 5]}}
{"token": ["Here", "we", "show", "that", "matrix", "metalloproteinase", "9", "C1334523#ent", "<e1>", ")", "is", "involved", "in", "C1096184#ent", "<e2>", "entry", "into", "the", "brain", "by", "enhancing", "blood-brain", "barrier", "permeability", "."], "h": {"id": "C1334523", "name": "C1334523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1096184", "name": "C1096184#ent", "pos": [13, 14]}}
{"token": ["The", "linear", "multiple", "regression", "analysis", "performed", "between", "the", "dose", "of", "C0030310#ent", "<e1>", "(", "micrograms.kg-1.hr-1", ")", "and", "the", "dose", "of", "C0885378#ent", "<e2>", "(", "micrograms.kg-1.min-1", ")", ",", "the", "age", ",", "sex", ",", "or", "body", "weight", "the", "patients", "."], "h": {"id": "C0030310", "name": "C0030310#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0885378", "name": "C0885378#ent", "pos": [19, 20]}}
{"token": ["In", "the", "group", "with", "generalized", "epilepsy", "chronologic", "age", "C0014550#ent", "<e1>", "inversely", "correlated", "with", "aggression", ",", "while", "C4023498#ent", "<e2>", "directly", "associated", "with", "increased", "aggression", "."], "h": {"id": "C0014550", "name": "C0014550#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4023498", "name": "C4023498#ent", "pos": [16, 17]}}
{"token": ["Some", "tissue-specific", "features", ",", "however", ",", "observed", ",", "including", "varying", "rates", "of", "C0017875#ent", "<e1>", "activities", "and", "increased", "succinate", "dehydrogenase", "activity", "in", "C0023899#ent", "<e2>", "."], "h": {"id": "C0017875", "name": "C0017875#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [21, 22]}}
{"token": ["Finally", ",", "the", "proliferation", "defect", "Id3-deficient", "B", "cells", "can", "be", "rescued", "by", "ectopic", "expression", "of", "C1417167#ent", "<e1>", ",", "a", "homologue", "of", "C1144149#ent", "<e2>", "."], "h": {"id": "C1417167", "name": "C1417167#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1144149", "name": "C1144149#ent", "pos": [21, 22]}}
{"token": ["Neuron-specific", "enolase", "C1880904#ent", "<e1>", ")", "is", "a", "unique", "form", "of", "the", "C1947941#ent", "<e2>", "enolase", ",", "which", ",", "in", "the", "brain", ",", "is", "strictly", "localized", "in", "differentiated", "neurons", "and", "neuroendocrine", "cells"], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [11, 12]}}
{"token": ["Relaxation", "by", "C0037533#ent", "<e1>", "not", "different", "between", "sham", "and", "C0018801#ent", "<e2>", "rats", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [9, 10]}}
{"token": ["The", "blood", "flow", "response", "nitroglycerin", "or", "C0037533#ent", "<e1>", "endothelium-independent", "vasodilators", "is", "usually", "preserved", "in", "patients", "with", "chronic", ",", "C0018801#ent", "<e2>", "indicating", "a", "normal", "response", "the", "vascular", "smooth", "muscle", "resistance", "vessels", "exogenous", "nitric", "oxide"], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}}
{"token": ["Inhibitors", "of", "mitogen-activated", "protein/extracellular", "signal", "regulated", "kinase", "MEK", ")", ",", "such", "as", "ERK", "inhibitor", "PD98059", "and", "JNK", "inhibitors", "C0005640#ent", "<e1>", "and", "SP60015", ",", "but", "not", "p38", "inhibitor", "C0297666#ent", "<e2>", ",", "inhibited", "PMA-induced", "MUC5AC", "reporter", "activity"], "h": {"id": "C0005640", "name": "C0005640#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0297666", "name": "C0297666#ent", "pos": [27, 28]}}
{"token": ["Human", "nasal", "cilia", "perfused", "with", "aqueous", "solutions", "of", "two", "C3536709#ent", "<e1>", "aerosols", ",", "beclomethasone", "dipropionate", "BPD", ")", "and", "C0060501#ent", "<e2>", ",", "with", "the", "main", "preservative", "of", "C0060501#ent", "<e2>", ",", "propylene", "glycol", "and", "with", "placebo", "."], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0060501", "name": "C0060501#ent", "pos": [18, 19]}}
{"token": ["This", "paper", "reviews", "the", "current", "clinical", "information", "the", "newer", "C3536709#ent", "<e1>", "aerosols", "used", "in", "the", "management", "of", "rhinitis", ":", "beclomethasone", "dipropionate", "C0060501#ent", "<e2>", ",", "fluocortin", "butylester", ",", "budesonide", ",", "and", "triamcinolone", "acetonide"], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0060501", "name": "C0060501#ent", "pos": [21, 22]}}
{"token": ["Press-coated", "C0127615#ent", "<e1>", "tablets", "with", "a", "coat", "of", "C0063242#ent", "<e2>", "E-15", "were", "over-coated", "with", "Eudragit", "S100", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0063242", "name": "C0063242#ent", "pos": [8, 9]}}
{"token": ["Meglitinide", "and", "C0724709#ent", "<e1>", ",", "which", "represent", ",", "respectively", ",", "the", "benzamido", "and", "C0038766#ent", "<e2>", "glibenclamide", ",", "showed", "Hill", "coefficients", "0.8", "+", "/-", "0.1", "and", "0.9", "+", "/-", "0.1", ",", "respectively", "."], "h": {"id": "C0724709", "name": "C0724709#ent", "pos": [2, 3]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [13, 14]}}
{"token": ["C0724709#ent", "<e1>", "(", "TOLB", ")", "is", "a", "C0038766#ent", "<e2>", "used", "to", "treat", "non-insulin-dependent", "diabetes", "mellitus", "is", "a", "suspected", "teratogen", "."], "h": {"id": "C0724709", "name": "C0724709#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [7, 8]}}
{"token": ["Review", "of", "the", "available", "drug", "utilisation", "data", "indicated", "that", "glibenclamide", "and", "C0724709#ent", "<e1>", "are", "the", "most", "frequently", "used", "C0038766#ent", "<e2>", "in", "Hong", "Kong", "Singapore", ",", "respectively", "."], "h": {"id": "C0724709", "name": "C0724709#ent", "pos": [11, 12]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [18, 19]}}
{"token": ["A", "clinical", "trial", "C0025023#ent", "<e1>", "undertaken", "upon", "some", "intestinal", "C0018889#ent", "<e2>", "288", "rural", "Koreans", "residing", "in", "Pochun", "and", "Jinyang", "Gun", ",", "from", "November", "to", "December", ",", "1976", "."], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [9, 10]}}
{"token": ["C0025023#ent", "<e1>", "was", "highly", "effective", "against", "the", "C0018889#ent", "<e2>", "Trichinella", "spiralis", "mice", "subjected", "to", "a", "3-day", "course", "of", "treatment", "during", "the", "invasive", "and", "encystment", "phases", "of", "experimental", "trichinellosis"], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [7, 8]}}
{"token": ["The", "three", "main", "components", "of", "C3714974#ent", "<e1>", "are", "chronic", "mucocuteaneous", "candidiasis", "hypoparathyroidism", "and", "C0405580#ent", "<e2>"], "h": {"id": "C3714974", "name": "C3714974#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [13, 14]}}
{"token": ["Intranasal", "and", "C0428908#ent", "<e1>", "result", "in", "disabling", "head", "and", "C0015468#ent", "<e2>", "serious", "complications", "."], "h": {"id": "C0428908", "name": "C0428908#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015468", "name": "C0015468#ent", "pos": [9, 10]}}
{"token": ["Five", "of", "the", "523", "subjects", "who", "received", "tetanus", "toxoid", "developed", "C0025294#ent", "<e1>", "another", "four", "probably", "had", "C0025303#ent", "<e2>"], "h": {"id": "C0025294", "name": "C0025294#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025303", "name": "C0025303#ent", "pos": [16, 17]}}
{"token": ["Shifts", "in", "carriage", "and", "transmission", "of", "C0025294#ent", "<e1>", "different", "pathogenic", "potential", "are", "important", "determinants", "of", "C0025303#ent", "<e2>", "incidence", "."], "h": {"id": "C0025294", "name": "C0025294#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025303", "name": "C0025303#ent", "pos": [15, 16]}}
{"token": ["The", "data", "indicate", "that", "C1710304#ent", "<e1>", "induces", "an", "increase", "in", "vascular", "constriction", "response", "to", "C0917834#ent", "<e2>", "and", "a", "decrease", "in", "vasodilation", "in", "response", "to", "acetylcholine", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0917834", "name": "C0917834#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "we", "show", "that", "C0812201#ent", "<e1>", "is", "coexpressed", "with", "C0380093#ent", "<e2>", ",", "and", "overexpression", "experiments", "indicate", "that", "C0812201#ent", "<e1>", "can", "activate", "the", "C0380093#ent", "<e2>", "promoter", "through", "this", "element", "."], "h": {"id": "C0380093", "name": "C0380093#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812201", "name": "C0812201#ent", "pos": [5, 6]}}
{"token": ["Gelatinase", "otherwise", "exhibited", "properties", "typical", "of", "the", "C1334706#ent", "<e1>", ":", "it", "was", "inhibited", "by", "C3537172#ent", "<e2>", "by", "the", "specific", "inhibitor", "TIMP", "(", "tissue", "inhibitor", "C1334706#ent", "<e1>", ")", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537172", "name": "C3537172#ent", "pos": [14, 15]}}
{"token": ["Consistently", ",", "overexpression", "of", "a", "series", "of", "PML", "and", "C1414351#ent", "<e1>", "C1564139#ent", "<e2>", "that", "PML", "C1414351#ent", "<e1>", "interaction", "is", "required", "for", "the", "observed", "effects", "of", "cadmium", "and", "interferon", "treatment"], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414351", "name": "C1414351#ent", "pos": [9, 10]}}
{"token": ["We", "found", "that", "patients", "with", "C1704321#ent", "<e1>", "NS", ")", "had", "higher", "pre-treatment", "plasma", "C1706001#ent", "<e2>", "(", "P<0.001", ")", "and", "sTNFR2", "levels", "(", "P<0.001", ")", "than", "controls", "without", "NS", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706001", "name": "C1706001#ent", "pos": [13, 14]}}
{"token": ["C0025853#ent", "<e1>", "(", "10.0", "mg/kg", ")", "blocked", "conditioning", "based", "on", "C0072892#ent", "<e2>", "but", "not", "SKF", "38393", "."], "h": {"id": "C0025853", "name": "C0025853#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072892", "name": "C0072892#ent", "pos": [10, 11]}}
{"token": ["The", "C0001175#ent", "<e1>", "AIDS", ")", "is", "frequently", "associated", "with", "infections", ",", "C0851341#ent", "<e2>", ",", "or", "diseases", "of", "the", "gastrointestinal", "tract"], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0851341", "name": "C0851341#ent", "pos": [11, 12]}}
{"token": ["This", "report", "describes", "a", "38-year-old", "male", "homosexual", "with", "acquired", "C0001175#ent", "<e1>", "AIDS", ")", "and", "a", "history", "of", "Isospora", "belli", "C0851341#ent", "<e2>", "treated", "with", "trimethoprim-sulfamethoxazole", "."], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0851341", "name": "C0851341#ent", "pos": [19, 20]}}
{"token": ["In", "C1421638#ent", "<e1>", "cell", "lines", "estrogens", "and", "growth", "factors", "stimulate", "C1332805#ent", "<e2>", "expression", "through", "distinct", "mechanisms", "."], "h": {"id": "C1421638", "name": "C1421638#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332805", "name": "C1332805#ent", "pos": [10, 11]}}
{"token": ["This", "suggests", "that", "the", "putaminal", "atrophy", "is", "the", "primary", "lesion", "C0795996#ent", "<e1>", "which", "is", "a", "true", "supranigral", "form", "of", "C0030567#ent", "<e2>", "."], "h": {"id": "C0795996", "name": "C0795996#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [19, 20]}}
{"token": ["Animal", "models", "early", "stages", "striatonigral", "degeneration", "C0795996#ent", "<e1>", ")", ",", "the", "core", "pathology", "underlying", "C0030567#ent", "<e2>", "in", "multiple", "system", "atrophy", "are", "lacking", "."], "h": {"id": "C0795996", "name": "C0795996#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [14, 15]}}
{"token": ["So", "far", "our", "group", "has", "created", "a", "number", "of", "animal", "models", "C0795996#ent", "<e1>", "the", "core", "pathology", "underlying", "progressive", "C0030567#ent", "<e2>", "associated", "with", "multiple", "system", "atrophy", "as", "testbed", "for", "neurorestaurative", "and", "neuroprotective", "approaches", "."], "h": {"id": "C0795996", "name": "C0795996#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [18, 19]}}
{"token": ["The", "Hsp70", "family", "members", "an", "essential", "role", "in", "cellular", "protein", "metabolism", "acting", "as", "C1333685#ent", "<e1>", "and", "release", "factors", "that", "interact", "with", "nonnative", "regions", "of", "C0086376#ent", "<e2>", "at", "different", "stages", "of", "their", "life", "cycles"], "h": {"id": "C1333685", "name": "C1333685#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [24, 25]}}
{"token": ["Subsequent", "iontophoretic", "injections", "of", "Phaseolus", "vulgaris-leucoagglutinin", "or", "pressure", "injections", "C0982459#ent", "<e1>", "agglutinin-horseradish", "peroxidase", "made", "into", "regions", "containing", "identified", "C0237795#ent", "<e2>", "and", "depressor", "sites", "their", "connections", "with", "the", "forebrain", "and", "cerebral", "cortex", "traced", "."], "h": {"id": "C0982459", "name": "C0982459#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [18, 19]}}
{"token": ["Subsequent", "injections", "of", "Phaseolus", "vulgaris-leucoagglutinin", "(", "PHA-L", ")", "or", "C0982459#ent", "<e1>", "agglutinin-horseradish", "peroxidase", "WGA-HRP", ")", "were", "made", "into", "C0237795#ent", "<e2>", "or", "depressor", "sites", "their", "connections", "with", "the", "brainstem", "and", "spinal", "cord", "traced", "."], "h": {"id": "C0982459", "name": "C0982459#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [18, 19]}}
{"token": ["beta-Catenin", ",", "an", "essential", "component", "of", "the", "canonical", "Wnt", "signaling", "pathway", "was", "shown", "to", "be", "a", "C1422492#ent", "<e1>", "of", "the", "AR", "signaling", "in", "the", "presence", "of", "C0002842#ent", "<e2>", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [26, 27]}}
{"token": ["Increased", "levels", "of", "both", "the", "C0769345#ent", "<e1>", "cathepsin", "L", "and", "the", "serine", "protease", "C1706177#ent", "<e2>", "(", "urokinase-type", "plasminogen", "activator", ",", "are", "present", "in", "solid", "tumors", "are", "correlated", "with", "malignancy", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706177", "name": "C1706177#ent", "pos": [13, 14]}}
{"token": ["RNH-6270", "and", "C0753183#ent", "<e1>", "significantly", "decreased", "the", "expression", "of", "growth", "factor", "mRNAs", "and", "C0086376#ent", "<e2>", "in", "VSMC", "from", "SHR", ",", "but", "not", "in", "cells", "from", "WKY", "rats", "."], "h": {"id": "C0753183", "name": "C0753183#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["Both", "celiac", "disease", "C1705969#ent", "<e1>", ")", "and", "myocarditis", "can", "be", "associated", "with", "C0751871#ent", "<e2>", "however", ",", "the", "coexistence", "of", "the", "2", "entities", "has", "never", "been", "investigated", ",", "although", "its", "identification", "may", "have", "a", "clinical", "impact"], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751871", "name": "C0751871#ent", "pos": [12, 13]}}
{"token": ["Human", "melanin-concentrating", "hormone", "hMCH", ")", "is", "a", "potent", "but", "nonselective", "C2987634#ent", "<e1>", "at", "human", "C1825952#ent", "<e2>", "2", "(", "hMCH-1R", "and", "hMCH-2R", ",", "respectively", ")", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1825952", "name": "C1825952#ent", "pos": [14, 15]}}
{"token": ["Early", "C0023890#ent", "<e1>", "occurs", "in", "C0268490#ent", "<e2>", "peroxisomal", "diseases", "and", "glycogen", "storage", "disease", "type", "IV", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0268490", "name": "C0268490#ent", "pos": [5, 6]}}
{"token": ["In", "this", "study", ",", "we", "tested", "the", "value", "of", "EHBR", "for", "this", "purpose", ",", "using", "C0085542#ent", "<e1>", "(", "PV", ")", "and", "C0025677#ent", "<e2>", "(", "MTX", ")", "as", "model", "compounds"], "h": {"id": "C0085542", "name": "C0085542#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [21, 22]}}
{"token": ["C0020336#ent", "<e1>", "is", "used", "by", "35", "%", "of", "C0024141#ent", "<e2>", "patients", "enrolled", "in", "the", "Baltimore", "Lupus", "Cohort", "."], "h": {"id": "C0020336", "name": "C0020336#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [8, 9]}}
{"token": ["A", "case", "C0032858#ent", "<e1>", "diagnosed", "in", "a", "76-year-old", "man", "who", "had", "C0014038#ent", "<e2>"], "h": {"id": "C0032858", "name": "C0032858#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [11, 12]}}
{"token": ["The", "mobility", "of", "the", "integrin", "receptor", "C0041236#ent", "<e1>", "chick", "embryo", "fibroblasts", "CEF", ")", "was", "investigated", "using", "the", "C0010592#ent", "<e2>", "monoclonal", "antibody"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [17, 18]}}
{"token": ["C0041236#ent", "<e1>", "activated", "guinea", "pig", "C3", "and", "C5", "did", "not", "stimulate", "C0010592#ent", "<e2>", "release", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}}
{"token": ["C0041236#ent", "<e1>", "secretion", "was", "shown", "to", "be", "impaired", "at", "20", "mg/kg", "C0010592#ent", "<e2>", "only", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}}
{"token": ["In", "both", "assay", "systems", "L-glutamate", "stimulation", "C0170168#ent", "<e1>", "inhibited", "by", "C0043167#ent", "<e2>", "by", "the", "MEK", "(", "MAP/ERK", "activating", "kinase", "inhibitor", "PD", "98059", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [10, 11]}}
{"token": ["Although", "C1709384#ent", "<e1>", "inhibition", "by", "gene", "knockout", "increased", "the", "production", "of", "the", "C3540579#ent", "<e2>", "cytokines", "IL-2", "and", "IL-12", ",", "the", "inhibition", "by", "TIQ-A", "exerted", "no", "effect", "on", "these", "two", "cytokines", "."], "h": {"id": "C1709384", "name": "C1709384#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [12, 13]}}
{"token": ["To", "compare", "C0298130#ent", "<e1>", "pseudoephedrine", "hydrochloride", "the", "treatment", "of", "C0018621#ent", "<e2>"], "h": {"id": "C0298130", "name": "C0298130#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018621", "name": "C0018621#ent", "pos": [9, 10]}}
{"token": ["Likewise", ",", "delivery", "of", "C1334089#ent", "<e1>", "specifically", "into", "muscle", "has", "been", "proposed", "as", "a", "genetic", "therapy", "C0026848#ent", "<e2>"], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [16, 17]}}
{"token": ["This", "study", "further", "indicates", "that", "modulation", "of", "C1334089#ent", "<e1>", "signalling", "has", "therapeutic", "potential", "for", "C0026848#ent", "<e2>"], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [14, 15]}}
{"token": ["C0674653#ent", "<e1>", "also", "reduced", "an", "increase", "in", "plasma", "amylase", "induced", "by", "C2827312#ent", "<e2>", "."], "h": {"id": "C0674653", "name": "C0674653#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2827312", "name": "C2827312#ent", "pos": [11, 12]}}
{"token": ["Beh\u00e7et's", "disease", "a", "C0409818#ent", "<e1>", "a", "wide", "variety", "of", "clinical", "manifestations", "whereas", "recurrent", "C0038363#ent", "<e2>", "a", "local", "oral", "disease"], "h": {"id": "C0409818", "name": "C0409818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038363", "name": "C0038363#ent", "pos": [13, 14]}}
{"token": ["Several", "C3539947#ent", "<e1>", "in", "addition", "to", "C0010406#ent", "<e2>", "good", "protection", "of", "calcium", "uptake", "against", "FT", "damage", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010406", "name": "C0010406#ent", "pos": [6, 7]}}
{"token": ["Our", "results", "suggest", "the", "usefulness", "of", "cystatin", "for", "insect", "C0032064#ent", "<e1>", "control", "and", "also", "the", "critical", "role", "of", "C2717970#ent", "<e2>", "the", "digestive", "events", "insects", "."], "h": {"id": "C0032064", "name": "C0032064#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [18, 19]}}
{"token": ["It", "is", "not", "known", "at", "present", "whether", "C0669365#ent", "<e1>", "high", "intracellular", "levels", "of", "cyclin", "D1", "interfere", "with", "the", "C0010858#ent", "<e2>", "mevalonate/protein", "prenylation", "inhibitors", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [18, 19]}}
{"token": ["Importantly", ",", "cells", "that", "are", "C0669365#ent", "<e1>", "deficient", "in", "cybL", "are", "resistant", "to", "a", "variety", "of", "C0010858#ent", "<e2>", "to", "the", "effects", "of", "Fas", "receptor"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [16, 17]}}
{"token": ["The", "authors", "present", "a", "case", "report", "neuroleptic", "malignant", "syndrome", "C0027849#ent", "<e1>", ")", "in", "a", "patient", "commencing", "treatment", "with", "C0016365#ent", "<e2>", "alone", "who", "had", "previously", "been", "treated", "with", "antipsychotic", "and", "antidepressant", "combinations", "."], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [18, 19]}}
{"token": ["The", "authors", "present", "a", "case", "report", "C0027849#ent", "<e1>", "NMS", ")", "in", "a", "patient", "commencing", "treatment", "with", "C0016365#ent", "<e2>", "alone", "who", "had", "previously", "been", "treated", "with", "antipsychotic", "and", "antidepressant", "combinations", "."], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [16, 17]}}
{"token": ["Lesser", "elevations", "in", "Sj\u00f6gren's", "syndrome", "C0038013#ent", "<e1>", "ankylosing", "spondylitis", "and", "Crohn's", "disease", "but", "none", "with", "C0524909#ent", "<e2>"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [15, 16]}}
{"token": ["This", "includes", "C0038013#ent", "<e1>", "inflammatory", "bowel", "disease", "psoriasis", ",", "organ", "transplantation", "and", "C0524909#ent", "<e2>", "results", "are", "heterogeneous", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [12, 13]}}
{"token": ["As", "a", "control", ",", "250", "sera", "were", "tested", "of", "patients", "with", "various", "disorders", "such", "as", "SLE", ",", "C0038013#ent", "<e1>", "acute", "and", "C0524909#ent", "<e2>", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [21, 22]}}
{"token": ["The", "formation", "of", "immune", "complexes", "locally", "in", "cutaneous", "and", "C0023281#ent", "<e1>", "circulating", "in", "visceral", "leishmaniasis", "is", "considered", "responsible", "for", "these", "C1402315#ent", "<e2>"], "h": {"id": "C0023281", "name": "C0023281#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1402315", "name": "C1402315#ent", "pos": [20, 21]}}
{"token": ["C0151449#ent", "<e1>", "one", "of", "the", "major", "autoimmune", "diseases", "however", "C0014121#ent", "<e2>", "associated", "with", "C0151449#ent", "<e1>", "not", "previously", "been", "reported", "."], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [9, 10]}}
{"token": ["The", "data", "presented", "led", "us", "to", "assume", "that", "certain", "sequences", "in", "the", "C0032027#ent", "<e1>", "mRNA", "might", "be", "targets", "for", "C0086376#ent", "<e2>", "acting", "in", "trans", "."], "h": {"id": "C0032027", "name": "C0032027#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["However", ",", "purification", "of", "the", "nuclear", "proteins", "by", "an", "amino", "acid", "sequence", "analysis", "necessary", "to", "clarify", "whether", "C0032027#ent", "<e1>", "is", "part", "of", "these", "C0086376#ent", "<e2>", "."], "h": {"id": "C0032027", "name": "C0032027#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [23, 24]}}
{"token": ["After", "Highly", "Active", "Antiretroviral", "Therapy", "HAART", ")", "was", "started", ",", "malnutrition", "has", "declined", "and", "C1136321#ent", "<e1>", "emerged", "as", "an", "important", "C0025517#ent", "<e2>"], "h": {"id": "C1136321", "name": "C1136321#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [20, 21]}}
{"token": ["C1430988#ent", "<e1>", "(", "also", "known", "as", "MMAC-1", "or", "C0289499#ent", "<e2>", ")", "is", "one", "of", "the", "most", "frequently", "mutated", "tumor", "suppressors", "in", "human", "cancer"], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0289499", "name": "C0289499#ent", "pos": [8, 9]}}
{"token": ["At", "the", "common", "chromosomal", "region", "amplification", "(", "4q22", ")", "in", "rat", "RCCs", ",", "we", "found", "ptprz1", ",", "a", "C1430988#ent", "<e1>", "also", "known", "as", "C0289499#ent", "<e2>", "receptor", "tyrosine", "phosphatase", "beta", "highly", "expressed", "in", "the", "RCCs", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0289499", "name": "C0289499#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "a", "clinical", "syndrome", "delayed", "C0393593#ent", "<e1>", "in", "children", "subsequent", "to", "initial", "gastrointestinal", "symptoms", "C3542501#ent", "<e2>"], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3542501", "name": "C3542501#ent", "pos": [15, 16]}}
{"token": ["One", "of", "these", "C0086376#ent", "<e1>", ",", "CEACAM28", ",", "exhibits", "nearly", "complete", "sequence", "identity", "the", "ligand-binding", "N", "domain", "C1413306#ent", "<e2>", ",", "but", "antagonizing", "signaling", "motifs", "in", "the", "cytoplasmic", "tail"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413306", "name": "C1413306#ent", "pos": [17, 18]}}
{"token": ["Immunoprecipitation", "and", "subsequent", "gel", "electrophoresis", "C0086376#ent", "<e1>", "from", "neutrophils", "labeled", "with", "[gamma-32P]ATP", "revealed", "that", "C1413306#ent", "<e2>", "recognize", "a", "approximately", "180-kDa", "phosphoprotein", "on", "the", "surface", "of", "human", "neutrophils", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413306", "name": "C1413306#ent", "pos": [14, 15]}}
{"token": ["There", "is", "considerable", "divergence", "in", "the", "amino", "acid", "sequences", "the", "N-terminal", "domains", "of", "the", "C0086376#ent", "<e1>", "coded", "by", "the", "C1413306#ent", "<e2>", "gene", "from", "that", "of", "the", "Bgp2-encoded", "protein", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413306", "name": "C1413306#ent", "pos": [19, 20]}}
{"token": ["Modern", "treatment", "C0034013#ent", "<e1>", "CPP", ")", "by", "C0243192#ent", "<e2>", "analogues", "of", "gonadoliberin", "(", "aGnRH", ")", "block", "the", "development", "of", "secondary", "sex", "characteristics", ",", "it", "delays", "bone", "maturation", "improves", "the", "prospects", "of", "reaching", "optimal", "height", "."], "h": {"id": "C0034013", "name": "C0034013#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [7, 8]}}
{"token": ["C0002144#ent", "<e1>", "(", "Al", ")", ",", "a", "C0221333#ent", "<e2>", "provides", "no", "substantial", "clinical", "improvement"], "h": {"id": "C0002144", "name": "C0002144#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221333", "name": "C0221333#ent", "pos": [7, 8]}}
{"token": ["Mycobacterial", "C0238446#ent", "<e1>", "the", "hand", "is", "a", "rare", "manifestation", "of", "C0679362#ent", "<e2>", "while", "mycobacterial", "C0238446#ent", "<e1>", "the", "extensor", "tendon", "sheath", "is", "extremely", "rare", "."], "h": {"id": "C0679362", "name": "C0679362#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0238446", "name": "C0238446#ent", "pos": [1, 2]}}
{"token": ["Thirty-three", "polymerase", "chain", "reaction", "products", "identified", "as", "PTP", "related", "complementary", "C0011519#ent", "<e1>", ",", "were", "classified", "to", "RPTP-alpha", ",", "C1335281#ent", "<e2>", ",", "and", "4", "novel", "PTPs", ",", "which", "were", "designated", "as", "BPTP-1", "-", "4", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335281", "name": "C1335281#ent", "pos": [18, 19]}}
{"token": ["C3539645#ent", "<e1>", "inhibition", "blocked", "menadione-induced", "phosphorylation", "of", "C2987024#ent", "<e2>", ",", "and", "expression", "of", "a", "constitutively", "active", "C2987024#ent", "<e2>", "prevented", "death", "from", "Ro-31", "-", "8425/menadione", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987024", "name": "C2987024#ent", "pos": [7, 8]}}
{"token": ["The", "pharmacological", "inhibitors", "phospholipase", "Cgamma", "PLCgamma", ")", "and", "protein", "kinase", "C", "C3539645#ent", "<e1>", ")", "significantly", "inhibited", "VEGF-induced", "C2987024#ent", "<e2>", "activation", ",", "suggesting", "the", "involvement", "of", "the", "PLCgamma/PKC", "pathway", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987024", "name": "C2987024#ent", "pos": [17, 18]}}
{"token": ["We", "assessed", "an", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitor", ",", "C0072973#ent", "<e1>", ",", "to", "prevent", "the", "development", "of", "C0018802#ent", "<e2>", "high-risk", "patients", "without", "known", "low", "ejection", "fraction", "C0018802#ent", "<e2>"], "h": {"id": "C0072973", "name": "C0072973#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["Benazepril", ",", "enalapril", ",", "imidapril", "and", "C0072973#ent", "<e1>", "are", "approved", "for", "dogs", "with", "chronic", "heart", "failure", "C0018802#ent", "<e2>", ")", "."], "h": {"id": "C0072973", "name": "C0072973#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "if", "C1420331#ent", "<e1>", "also", "has", "a", "role", "in", "a", "gecko", "species", "with", "C0039373#ent", "<e2>", ",", "we", "studied", "gonadal", "expression", "of", "C1420331#ent", "<e1>", "during", "embryonic", "development", "the", "Leopard", "gecko", "Eublepharis", "macularius", "."], "h": {"id": "C1420331", "name": "C1420331#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039373", "name": "C0039373#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", "the", "Evi3", "gene", "is", "overexpressed", "in", "several", "tumors", "with", "viral", "insertions", "Evi3", ",", "which", "results", "in", "the", "upregulation", "of", "C2699988#ent", "<e1>", "gene", "expression", "suggesting", "that", "Evi3", "modulates", "C1825022#ent", "<e2>", "activity", "."], "h": {"id": "C2699988", "name": "C2699988#ent", "pos": [22, 23]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1825022", "name": "C1825022#ent", "pos": [30, 31]}}
{"token": ["Although", "both", "C3540772#ent", "<e1>", "had", "specificity", "for", "C1413857#ent", "<e2>", "as", "substrates", ",", "AR", "I", "two", "to", "three", "times", "larger", "turnover", "numbers", "with", "aromatic", "aldehydes", "hexonates", "than", "did", "AR", "II"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413857", "name": "C1413857#ent", "pos": [7, 8]}}
{"token": ["Pectin", "is", "known", "to", "delay", "gastric", "emptying", "alleviate", "C1457887#ent", "<e1>", "ingested", "with", "C0020457#ent", "<e2>", ",", "glucose-containing", "meals", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020457", "name": "C0020457#ent", "pos": [12, 13]}}
{"token": ["The", "results", "suggest", "that", "metaphit", "acts", "not", "as", "an", "antagonist", "of", "C1422070#ent", "<e1>", "but", "as", "a", "less-potent", ",", "long-acting", ",", "specific", "PCP-like", "C2987634#ent", "<e2>", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [22, 23]}}
{"token": ["These", "results", "suggest", "that", "metaphit", "acts", "not", "as", "an", "antagonist", "of", "C1422070#ent", "<e1>", "but", "as", "a", "PCP-like", "C2987634#ent", "<e2>", "under", "these", "conditions", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [17, 18]}}
{"token": ["To", "study", "effects", "of", "(", "C2609259#ent", "<e1>", ")", "on", "the", "phosphorylation", "of", "a", "dopamine-", "and", "cAMP-regulated", "phosphoprotein", "C1418825#ent", "<e2>", ")", "in", "the", "striatum", "of", "oxidopamine-lesioned", "rats", "."], "h": {"id": "C2609259", "name": "C2609259#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418825", "name": "C1418825#ent", "pos": [17, 18]}}
{"token": ["In", "patients", "with", "chronic", "myelocytic", "leukemia", "CML", ")", ",", "the", "C0812385#ent", "<e1>", "fusion", "between", "the", "C0105421#ent", "<e2>", "and", "the", "c-ABL", "genes", "BCR-ABL", ")", "oncogen", "product", "a", "potential", "tumor-specific", "antigen"], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [15, 16]}}
{"token": ["The", "breakpoint", "cluster", "region", "C0812385#ent", "<e1>", ")", "of", "the", "C0105421#ent", "<e2>", "found", "to", "be", "rearranged", "in", "these", "cells", "by", "Southern", "blot", "analysis", "a", "major", "3'-side", "bcr", "probe", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [9, 10]}}
{"token": ["The", "majority", "of", "breakpoints", "in", "C0812385#ent", "<e1>", "occur", "within", "a", "5", "kb", "major", "C0105421#ent", "<e2>", "M-Bcr", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [13, 14]}}
{"token": ["Fructose-1,6-biphosphate", "and", "alanine", "act", "as", "allosteric", "modulators", "of", "C1418609#ent", "<e1>", "haematopoietic", "cells", "while", "in", "erythrocytes", "although", "C1414544#ent", "<e2>", "exerts", "also", "allosteric", "effect", "alanine", "appears", "to", "be", "a", "competitive", "inhibitor", "."], "h": {"id": "C1418609", "name": "C1418609#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414544", "name": "C1414544#ent", "pos": [16, 17]}}
{"token": ["C1418609#ent", "<e1>", "not", "require", "C1414544#ent", "<e2>", "for", "its", "activity", ",", "and", "by", "this", "way", ",", "did", "not", "regulate", "the", "glycolytic", "flux.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1418609", "name": "C1418609#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414544", "name": "C1414544#ent", "pos": [4, 5]}}
{"token": ["C0520909#ent", "<e1>", "was", "absent", "in", "68", "%", "of", "the", "patients", "after", "C0700478#ent", "<e2>", "and", "in", "88", "%", "after", "droperidol", "(", "P", "<", "0.05", ")", "."], "h": {"id": "C0520909", "name": "C0520909#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0700478", "name": "C0700478#ent", "pos": [11, 12]}}
{"token": ["Recovery", "time", "P=0.07", ")", ",", "fast", "tracking", "time", "P=0.6", ")", ",", "parental", "satisfaction", "scores", "P=0.08", ")", "and", "NNTP", "C0520909#ent", "<e1>", "were", "comparable", "(", "NNTP=2", ")", "in", "both", "the", "C0700478#ent", "<e2>", "and", "the", "dexamethasone", "group"], "h": {"id": "C0520909", "name": "C0520909#ent", "pos": [18, 19]}, "relation": "may_be_prevented_by", "t": {"id": "C0700478", "name": "C0700478#ent", "pos": [28, 29]}}
{"token": ["Indomethacin", ",", "a", "C3536910#ent", "<e1>", "phosphoramidon", ",", "an", "C0246118#ent", "<e2>", "did", "not", "affect", "iPE2-III", "response", "."], "h": {"id": "C3536910", "name": "C3536910#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0246118", "name": "C0246118#ent", "pos": [8, 9]}}
{"token": ["Triglyceride", "composition", "was", "calculated", "from", "the", "fatty", "acid", "compositions", "of", "the", "native", "oil", "and", "of", "the", "C0017860#ent", "<e1>", "produced", "from", "it", "by", "C0443469#ent", "<e2>", "hydrolysis", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0443469", "name": "C0443469#ent", "pos": [22, 23]}}
{"token": ["Fish", "oils", "different", "levels", "of", "polymers", "of", "C0017860#ent", "<e1>", "formed", "during", "autoxidation", "were", "incubated", "with", "C0443469#ent", "<e2>", "establish", "whether", "these", "polymers", "are", "substrates", "for", "lipase", "hydrolysis"], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0443469", "name": "C0443469#ent", "pos": [15, 16]}}
{"token": ["C0072259#ent", "<e1>", "PGIS", ")", "is", "a", "member", "of", "the", "C0010762#ent", "<e2>", "which", "the", "oxyferrous", "complexes", "are", "generally", "labile", "in", "the", "absence", "of", "substrate", "."], "h": {"id": "C0072259", "name": "C0072259#ent", "pos": [0, 1]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [9, 10]}}
{"token": ["The", "prostacyclin", "synthase", "enzyme", "CYP8A1", ",", "C0072259#ent", "<e1>", "is", "the", "unique", "member", "of", "family", "8", "the", "C0010762#ent", "<e2>"], "h": {"id": "C0072259", "name": "C0072259#ent", "pos": [6, 7]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [16, 17]}}
{"token": ["The", "residual", "activity", "irradiation", "is", "less", "refractory", "to", "C3272387#ent", "<e1>", "inhibition", "and", "less", "sensitive", "to", "C1412125#ent", "<e2>", "stimulation", "compared", "to", "non-irradiated", "hyaluronidase", "."], "h": {"id": "C3272387", "name": "C3272387#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [15, 16]}}
{"token": ["Biochemical", "parameters", "of", "the", "blood", "(", "Ca", ",", "P", ",", "total", "protein", "AlAT", ",", "C1845028#ent", "<e1>", ")", "also", "indicated", "the", "corrective", "effect", "this", "C2917660#ent", "<e2>"], "h": {"id": "C1845028", "name": "C1845028#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [23, 24]}}
{"token": ["Using", "serial", "analysis", "gene", "expression", "SAGE", ")", ",", "we", "recently", "identified", "CSTC", "as", "one", "of", "the", "C1417679#ent", "<e1>", "that", "are", "overexpressed", "after", "electrically", "induced", "C0085543#ent", "<e2>", "SE", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [24, 25]}}
{"token": ["The", "close", "apposition", "of", "the", "regions", "protected", "by", "C1367457#ent", "<e1>", "and", "polymerase", "provides", "evidence", "that", "accurate", "transcription", "of", "the", "C0035899#ent", "<e2>", "be", "achieved", "through", "protein-protein", "contacts", "well", "as", "through", "DNA-protein", "interactions"], "h": {"id": "C1367457", "name": "C1367457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035899", "name": "C0035899#ent", "pos": [19, 20]}}
{"token": ["In", "vivo", "imaging", "of", "green-fluorescent", "protein", "GPF", ")", "fusions", "showed", "that", "both", "C1428222#ent", "<e1>", "and", "App", "were", "associated", "with", "chromatin", "through", "the", "C1539078#ent", "<e2>"], "h": {"id": "C1428222", "name": "C1428222#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [22, 23]}}
{"token": ["C1417679#ent", "<e1>", "of", "the", "tumor", "suppressor", "gene", "C1332010#ent", "<e2>", ")", "cluster", "act", "together", "to", "suppress", "tumor", "growth", "their", "functional", "activation", "of", "tumor", "suppressing", "pathways", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332010", "name": "C1332010#ent", "pos": [7, 8]}}
{"token": ["The", "amino", "acid", "sequences", "from", "the", "cloned", "cDNA", "sequences", "56", "-", "61", "%", "identity", "with", "those", "of", "both", "C0030306#ent", "<e1>", "II", ",", "similar", "to", "the", "homology", "between", "C0030306#ent", "<e1>", "II", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [18, 19]}}
{"token": ["A", "polymorphism", "locating", "at", "position", "73", "of", "cystatin", "C", "C1706555#ent", "<e1>", ")", "exon", "1", "suggested", "to", "be", "associated", "with", "C0002395#ent", "<e2>", "AD", ")", ",", "but", "with", "contradictory", "results", "."], "h": {"id": "C1706555", "name": "C1706555#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}}
{"token": ["The", "prostacyclin", "synthase", "C1419071#ent", "<e1>", ")", "gene", "is", "a", "candidate", "C0079429#ent", "<e2>", "for", "cardiovascular", "disease"], "h": {"id": "C1419071", "name": "C1419071#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}}
{"token": ["Several", "C1333196#ent", "<e1>", "and", "immediate", "early", "(", "e.g.", ",", "C0087140#ent", "<e2>", "and", "c-jun", ")", "mRNAs", "are", "upregulated", "by", "ciprofloxacin", ",", "possibly", "reflecting", "a", "mammalian", "stress", "response"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [9, 10]}}
{"token": ["infusion", "of", "the", "C1333196#ent", "<e1>", "markedly", "augmented", "C0087140#ent", "<e2>", "expression", "in", "the", "paraventricular", "nucleus", "PVN", ")", "and", "the", "arcuate", "nucleus", "ARC", ")", "of", "the", "hypothalamus", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [7, 8]}}
{"token": ["No", "mutations", "were", "found", "in", "the", "C0920288#ent", "<e1>", "but", "a", "mutation", "was", "detected", "in", "the", "C1335202#ent", "<e2>"], "h": {"id": "C0920288", "name": "C0920288#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335202", "name": "C1335202#ent", "pos": [15, 16]}}
{"token": ["C0057981#ent", "<e1>", "(", "SC-26100", ")", "is", "closely", "related", "to", "the", "C0003292#ent", "<e2>", "diphenoxylate", ",", "which", "is", "a", "chemical", "congener", "meperidine", "."], "h": {"id": "C0057981", "name": "C0057981#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003292", "name": "C0003292#ent", "pos": [10, 11]}}
{"token": ["C0057981#ent", "<e1>", ",", "a", "new", "C0003292#ent", "<e2>", "had", "no", "effect", "lower", "esophageal", "sphincter", "pressure", "in", "man", "when", "given", "at", "an", "oral", "dose", "2", "mg", "."], "h": {"id": "C0057981", "name": "C0057981#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003292", "name": "C0003292#ent", "pos": [5, 6]}}
{"token": ["This", "unit", "presents", "characteristics", "and", "reaction", "conditions", "the", "DNA-dependent", "DNA", "polymerases", "including", "E.", "coli", "DNA", "polymerase", "I", "its", "Klenow", "fragment", "C0012892#ent", "<e1>", "native", "and", "modified", "T7", "DNA", "polymerase", "phi29", "DNA", "polymerase", "Bst", "DNA", "polymerase", "and", "C0075813#ent", "<e2>"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [20, 21]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0075813", "name": "C0075813#ent", "pos": [35, 36]}}
{"token": ["Commonly", "used", "C0012892#ent", "<e1>", "PCR", "amplification", "include", "those", "from", "Thermus", "aquaticus", "C0075813#ent", "<e2>", ")", "and", "Pyrococcus", "furiosus", "Pfu", ")", "."], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0075813", "name": "C0075813#ent", "pos": [11, 12]}}
{"token": ["The", "AUC", "(", "area", "under", "the", "curve", ")", "of", "C0079083#ent", "<e1>", "predicted", "by", "Calvert", "'s", "equation", "significantly", "affected", "the", "degree", "of", "C1839163#ent", "<e2>", "."], "h": {"id": "C0079083", "name": "C0079083#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [21, 22]}}
{"token": ["We", "investigated", "whether", "intra-arterial", "administration", "C0079083#ent", "<e1>", "using", "Calvert", "'s", "formula", "is", "useful", "for", "avoiding", "C1839163#ent", "<e2>", "in", "targeted", "chemoradiotherapy", "in", "patients", "with", "squamous", "cell", "cancer", "the", "oral", "cavity", "oropharynx", "."], "h": {"id": "C0079083", "name": "C0079083#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [15, 16]}}
{"token": ["The", "isolated", "peptides", "have", "high", "sequence", "similarity", "C0086376#ent", "<e1>", "such", "as", "C1539051#ent", "<e2>", "G", "protein-coupled", "receptor", "MRGX3", ",", "tumor", "necrosis", "factor", "superfamily", "member", "9", ")", ",", "and", "c-Jun", "N-terminal", "kinase", "3"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539051", "name": "C1539051#ent", "pos": [11, 12]}}
{"token": ["The", "obstruction", "is", "usually", "unilateral", ",", "but", "the", "posterior", "extension", "of", "a", "bulky", "polyp", "to", "the", "oropharynx", "can", "cause", "a", "major", "C2364135#ent", "<e1>", ",", "sometimes", "a", "C0476273#ent", "<e2>"], "h": {"id": "C2364135", "name": "C2364135#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [26, 27]}}
{"token": ["C1631597#ent", "<e1>", "PVT", ")", "is", "characterized", "by", "episodes", "of", "syncope", ",", "C0036572#ent", "<e2>", "or", "sudden", "death", "in", "response", "to", "physical", "activity", "emotional", "stress", "and", "affects", "mainly", "young", "children", "with", "morphologically", "normal", "hearts", "."], "h": {"id": "C1631597", "name": "C1631597#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "the", "displacement", "of", "C1418244#ent", "<e1>", "by", "the", "C0017860#ent", "<e2>", "is", "facilitated", "under", "shear", "conditions"], "h": {"id": "C1418244", "name": "C1418244#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [10, 11]}}
{"token": ["The", "penetration", "of", "C1418244#ent", "<e1>", "into", "the", "C0017860#ent", "<e2>", "monolayer", "with", "a", "more", "condensed", "structure", "at", "the", "collapse", "point", "of", "the", "C0017860#ent", "<e2>", ",", "requires", "C0017860#ent", "<e2>", "molecular", "loss", "collapse", "and/or", "desorption", "."], "h": {"id": "C1418244", "name": "C1418244#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [7, 8]}}
{"token": ["Thus", "the", "indigenously", "purified", "glycyrrhizin", "seems", "to", "be", "more", "potent", "C0003451#ent", "<e1>", "Licorice", "and", "ammonium", "salt", "C0061751#ent", "<e2>", "Sigma", ")", "for", "JEV", "'", "in", "vitro", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0061751", "name": "C0061751#ent", "pos": [16, 17]}}
{"token": ["Chronic", "rhinitis", "defined", "as", "the", "usual", "presence", "of", "symptoms", "of", "blocked", "or", "running", "nose", "apart", "from", "C0009443#ent", "<e1>", "or", "the", "C0021400#ent", "<e2>", ",", "lasting", "for", "more", "than", "a", "year", "."], "h": {"id": "C0009443", "name": "C0009443#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [20, 21]}}
{"token": ["The", "result", "of", "the", "present", "study", "supports", "the", "concept", "of", "targeted", "screening", "C3501835#ent", "<e1>", "countries", "with", "large", "populations", "of", "white", "(", "Caucasian", ")", "C1647218#ent", "<e2>", "patients", "."], "h": {"id": "C3501835", "name": "C3501835#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [23, 24]}}
{"token": ["Serum", "C1413916#ent", "<e1>", "was", "followed", "in", "seven", "patients", "who", "had", "experienced", "primary", "C0038525#ent", "<e2>", "from", "a", "ruptured", "intracranial", "aneurysm"], "h": {"id": "C1413916", "name": "C1413916#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [12, 13]}}
{"token": ["C1413916#ent", "<e1>", "activity", "was", "determined", "in", "the", "patients", "who", "underwent", "C0038525#ent", "<e2>", "to", "had", "following", "surgery", "."], "h": {"id": "C1413916", "name": "C1413916#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [10, 11]}}
{"token": ["C0074414#ent", "<e1>", "is", "metabolized", "to", "hexa-fluoro-isopropanol", "and", "inorganic", "fluoride", "the", "human", "C0023899#ent", "<e2>", "."], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "pharmacokinetics", "of", "uptake", "and", "elimination", "of", "C0074414#ent", "<e1>", "in", "brain", ",", "C0023899#ent", "<e2>", ",", "muscle", ",", "venous", "blood", "arterial", "blood", "rabbits", "."], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "levels", "of", "plasma", "C0004002#ent", "<e1>", "activities", "were", "reduced", "by", "Sm", "and", "C0037135#ent", "<e2>", "treatment", "."], "h": {"id": "C0004002", "name": "C0004002#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037135", "name": "C0037135#ent", "pos": [13, 14]}}
{"token": ["It", "remains", "to", "be", "elucidated", ",", "however", ",", "to", "what", "extent", "C1417809#ent", "<e1>", "expression", "in", "immortalized", "C1415169#ent", "<e2>", "neurons", "reflects", "a", "co-localization", "in", "situ", "C1417809#ent", "<e1>", "and", "C1415169#ent", "<e2>", "peptides", "."], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417809", "name": "C1417809#ent", "pos": [11, 12]}}
{"token": ["We", "also", "advocate", "the", "use", "of", "insulin", "C0162830#ent", "<e1>", "drugs", "to", "reduce", "miscarriage", "rates", ",", "and", "risks", "associated", "with", "C1956346#ent", "<e2>", "gestational", "diabetes", "obesity", "."], "h": {"id": "C0162830", "name": "C0162830#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [19, 20]}}
{"token": ["All", "five", "drugs", "produced", "phencyclidine-like", "responding", "at", "the", "higher", "doses", ",", "with", "the", "order", "of", "potency", "being", "phencyclidine", ",", "C0015135#ent", "<e1>", ",", "cyclazocine", ",", "dexoxadrol", "and", "C0700541#ent", "<e2>", "."], "h": {"id": "C0015135", "name": "C0015135#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0700541", "name": "C0700541#ent", "pos": [26, 27]}}
{"token": ["The", "down-regulation", "of", "C1420744#ent", "<e1>", "caused", "a", "stable", "interaction", "of", "C1418919#ent", "<e2>", "with", "Cx43", "even", "without", "normal", "enzyme", "activation", "by", "TPA", "."], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418919", "name": "C1418919#ent", "pos": [10, 11]}}
{"token": ["Decreased", "FSH-inducible", "C1366496#ent", "<e1>", "activity", "and", "increased", "secretion", "of", "C1366439#ent", "<e2>", "ABP", ")", "were", "used", "as", "parameters", "of", "androgen", "action", "Sertoli", "cells"], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [9, 10]}}
{"token": ["Decreased", "FSH-inducible", "C1366496#ent", "<e1>", "activity", "and", "increased", "secretion", "of", "androgen-binding", "protein", "C1366439#ent", "<e2>", ")", "were", "used", "as", "parameters", "of", "androgen", "action", "Sertoli", "cells"], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [11, 12]}}
{"token": ["In", "Arabidopsis", "(", "Arabidopsis", "thaliana", ",", "two", "genes", "encode", "small", "subunits", "C3714974#ent", "<e1>", "and", "APS2", ")", "and", "four", "large", "C0599220#ent", "<e2>", "(", "APL1-APL4", ")", "."], "h": {"id": "C3714974", "name": "C3714974#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [19, 20]}}
{"token": ["The", "full-length", "gene", "consists", "of", "a", "1,548-bp", "open", "reading", "frame", "encoding", "a", "58.8-kDa", "translated", "C0030956#ent", "<e1>", "containing", "DHFR", "and", "C1420620#ent", "<e2>", "domains", "linked", "together", "in", "a", "single", "polypeptide", "chain"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "suggested", "that", "the", "identified", "C0030956#ent", "<e1>", "could", "be", "used", "as", "new", "C1420620#ent", "<e2>", "inhibitors", "and", "developed", "to", "a", "novel", "class", "of", "anticancer", "agents"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [13, 14]}}
{"token": ["The", "electrophoretic", "gel", "mobility", "shift", "in", "vitro", "translation", "assays", "that", "the", "C0030956#ent", "<e1>", "selected", "using", "mRNA", "display", "could", "bind", "C1420620#ent", "<e2>", "RNA", "specifically", "and", "inhibit", "the", "translation", "of", "C1420620#ent", "<e2>", "mRNA", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [19, 20]}}
{"token": ["We", "assessed", "P.", "falciparum", "polymorphisms", "associated", "with", "resistance", "to", "C0165603#ent", "<e1>", "(", "cytochrome", "b", ",", "cytb", ")", "and", "to", "C0056751#ent", "<e2>", ",", "the", "active", "compound", "proguanil", "(", "dihydrofolate", "reductase", "dhfr", ")", "in", "100", "isolates", "from", "northern", "Ghana"], "h": {"id": "C0165603", "name": "C0165603#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0056751", "name": "C0056751#ent", "pos": [19, 20]}}
{"token": ["These", "studies", "identify", "C1415304#ent", "<e1>", "as", "a", "novel", "C0244988#ent", "<e2>", "substrate", "and", "reveal", "a", "mechanism", "by", "which", "C0244988#ent", "<e2>", "contributes", "to", "cellular", "polarization", "directionally", "migrating", "cells", "via", "effects", "on", "Rho", "GTPase", "activity"], "h": {"id": "C1415304", "name": "C1415304#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "have", "identified", "an", "additional", "regulatory", "mechanism", "to", "C1415304#ent", "<e1>", "RhoGAP", "that", "involves", "priming-dependent", "phosphorylation", "by", "glycogen", "synthase-3-beta", "C0244988#ent", "<e2>", ")", ",", "a", "kinase", "previously", "implicated", "in", "establishing", "cell", "polarity"], "h": {"id": "C1415304", "name": "C1415304#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [20, 21]}}
{"token": ["To", "develop", "a", "clinical", "model", "the", "prediction", ",", "at", "the", "first", "visit", ",", "of", "3", "forms", "of", "C0003864#ent", "<e1>", "outcome", ":", "self-limiting", ",", "persistent", "nonerosive", ",", "and", "persistent", "C3898123#ent", "<e2>"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C3898123", "name": "C3898123#ent", "pos": [28, 29]}}
{"token": ["The", "course", "of", "this", "C0003864#ent", "<e1>", "showed", "chronicity", "and", "mild", ",", "persistent", ",", "C3898123#ent", "<e2>", "joint", "effusions"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C3898123", "name": "C3898123#ent", "pos": [13, 14]}}
{"token": ["Off-label", "use", "bevacizumab", "(", "Avastin", ")", ",", "a", "recombinant", "humanized", "monoclonal", "antibody", "against", "C2349086#ent", "<e1>", ",", "in", "some", "C0268790#ent", "<e2>", "the", "eye", "has", "been", "associated", "with", "short", "term", "results", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [18, 19]}}
{"token": ["Nitric", "oxide", "synthase", "NOS", ")", "inhibitor", "augmented", "the", "tension", "response", "C0035179#ent", "<e1>", ",", "phentolamine", ",", "propranolol", ",", "C0036442#ent", "<e2>", ",", "atropine", ",", "adrenalectomy", ",", "indomethacin", ",", "angiotensin", "AT(1", ")", "and", "endothelin", "ET(A)", "receptor", "antagonists", "no", "effect"], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [17, 18]}}
{"token": ["All", "animals", "were", "pretreated", "with", "10", "mg/kg", "C0035179#ent", "<e1>", "and", "either", "1", "or", "5", "mg/kg", "C0036442#ent", "<e2>", "to", "abolish", "EEG", "activation", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [15, 16]}}
{"token": ["Patch", "clamp", "recordings", "from", "adult", "and", "C3714757#ent", "<e1>", "neurons", "confirmed", "that", "PKA", "decreases", "C3537389#ent", "<e2>", "activity", "only", "in", "adults", "."], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3537389", "name": "C3537389#ent", "pos": [13, 14]}}
{"token": ["C0010592#ent", "<e1>", "(", "CYA", ")", "reduces", "the", "renal", "synthesis", "C3540754#ent", "<e2>", "of", "the", "E", "series", "PGE", ")", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [9, 10]}}
{"token": ["C0010592#ent", "<e1>", "CsA", ")", "alters", "the", "production", "of", "C3540754#ent", "<e2>", "(", "PG", ")", "by", "the", "kidney", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [8, 9]}}
{"token": ["The", "major", "enzymes", "catalyzing", "this", "conjugation", "reaction", "members", "of", "the", "UDP-glucuronosyl", "transferase", "UGT", ")", "1A", "family", "and", "include", "UGT1A1", "and", "C1622228#ent", "<e1>", ",", "with", "minor", "contributions", "by", "C1421323#ent", "<e2>", "."], "h": {"id": "C1622228", "name": "C1622228#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1421323", "name": "C1421323#ent", "pos": [27, 28]}}
{"token": ["Likewise", ",", "coexpression", "of", "C1415288#ent", "<e1>", "together", "with", "full-length", "wild", "type", "C1334867#ent", "<e2>", "enhances", "C1415288#ent", "<e1>", "surface", "expression", "in", "fibroblasts", ",", "whereas", "full-length", "GRIP1-S917D", "had", "no", "effect"], "h": {"id": "C1415288", "name": "C1415288#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334867", "name": "C1334867#ent", "pos": [11, 12]}}
{"token": ["Similarly", ",", "norepinephrine", "depressed", "excitatory", "synaptic", "transmission", "the", "C1622105#ent", "<e1>", "by", "an", "C0001640#ent", "<e2>", "receptor-dependent", "mechanism", "but", "was", "without", "effect", "on", "excitatory", "transmission", "in", "the", "dorsal", "striatum"], "h": {"id": "C1622105", "name": "C1622105#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [12, 13]}}
{"token": ["Information", "about", "common", "C0026636#ent", "<e1>", "conditions", "were", "illustrated", "with", "enlarged", "pictures", "of", "dental", "caries", "C0017563#ent", "<e2>", "oral", "cancer", "cleft", "."], "h": {"id": "C0026636", "name": "C0026636#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [14, 15]}}
{"token": ["However", ",", "the", "greatest", "C0026636#ent", "<e1>", "burden", "results", "from", "dental", "caries", "C0017563#ent", "<e2>", "are", "complex", "disorders", "both", "hereditary", "and", "environmental", "factors", "disease", "risk", "progression", ",", "and", "course", "."], "h": {"id": "C0026636", "name": "C0026636#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [11, 12]}}
{"token": ["On", "a", "mole", "to", "mole", "basis", ",", "hCG", "was", "found", "to", "displace", "[125I]hCG", "from", "binding", "to", "receptors", "on", "C0010093#ent", "<e1>", "than", "hLH", "and", "C1418733#ent", "<e2>", "."], "h": {"id": "C0010093", "name": "C0010093#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1418733", "name": "C1418733#ent", "pos": [23, 24]}}
{"token": ["Substance", "P", "SP", ")", ",", "a", "C1420563#ent", "<e1>", "has", "been", "previously", "reported", "to", "stimulate", "C0879590#ent", "<e2>", "production", "in", "murine", "T", "cell", "lines", "activated", "with", "phorbol", "esters"], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [14, 15]}}
{"token": ["There", "are", "grounds", "for", "C0155862#ent", "<e1>", "be", "considered", "an", "C0028797#ent", "<e2>", "welders", "."], "h": {"id": "C0155862", "name": "C0155862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028797", "name": "C0028797#ent", "pos": [9, 10]}}
{"token": ["With", "a", "cDNA", "microarray", "we", "revealed", "that", "C1336664#ent", "<e1>", "tradd", ")", "gene", "expression", "elevated", "in", "response", "to", "C0164786#ent", "<e2>", "inactivation", "."], "h": {"id": "C1336664", "name": "C1336664#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [17, 18]}}
{"token": ["BPH", "activity", "remained", "low", "with", "raw", "beef", "C0950114#ent", "<e1>", "or", "not", "C0225326#ent", "<e2>", "was", "added", "."], "h": {"id": "C0950114", "name": "C0950114#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [11, 12]}}
{"token": ["Naivet\u00e9", "about", "diseases", ",", "such", "as", "malaria", ",", "C0277528#ent", "<e1>", "cholera", ",", "and", "C0019693#ent", "<e2>", "appears", "to", "be", "the", "most", "crucial", "factor", "determining", "travel-related", "morbidity", "rates", "."], "h": {"id": "C0277528", "name": "C0277528#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [13, 14]}}
{"token": ["The", "DISC1", "protein", "C1415740#ent", "<e1>", ",", "and", "a", "pool", "of", "C1414054#ent", "<e2>", "in", "the", "dynein", "motor", "complex", "required", "for", "neurite", "outgrowth", "PC12", "cells", "well", "as", "proper", "neuronal", "migration", "dendritic", "arborization", "the", "developing", "cerebral", "cortex", "in", "vivo"], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414054", "name": "C1414054#ent", "pos": [10, 11]}}
{"token": ["C0025598#ent", "<e1>", "increased", "the", "hexokinase", "activity", "the", "white", "gastrocnemius", ",", "the", "C1413745#ent", "<e2>", "activity", "in", "all", "three", "muscles", ",", "and", "the", "beta-hydroxyacyl-CoA", "dehydrogenase", "activity", "the", "soleus", "."], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413745", "name": "C1413745#ent", "pos": [11, 12]}}
{"token": ["Evidence", "from", "in", "vitro", "studies", "indicates", "that", "Lyprinol", "is", "not", "a", "smooth", "muscle", "relaxant", "and", "that", "its", "uterotrophic", "mechanism", "is", "not", "that", "of", "a", "C1257954#ent", "<e1>", "but", "may", "mimic", "that", "of", "a", "C0595726#ent", "<e2>"], "h": {"id": "C1257954", "name": "C1257954#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0595726", "name": "C0595726#ent", "pos": [32, 33]}}
{"token": ["A", "second", "set", "of", "baseline", "measurements", "was", "obtained", "and", "the", "sheep", "then", "received", "the", "combined", "C1257954#ent", "<e1>", "BW755C", ",", "the", "selective", "lipoxygenase", "inhibitor", ",", "or", "the", "C0595726#ent", "<e2>", "LY171883", "."], "h": {"id": "C1257954", "name": "C1257954#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0595726", "name": "C0595726#ent", "pos": [26, 27]}}
{"token": ["Our", "results", "demonstrate", "that", "C1334203#ent", "<e1>", "is", "critical", "for", "the", "LPS-induced", "activations", "of", "C1456795#ent", "<e2>", "."], "h": {"id": "C1334203", "name": "C1334203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [13, 14]}}
{"token": ["Immunoglobulin", "deposition", "myelin", "was", "observed", "only", "in", "the", "patients", "with", "C0030489#ent", "<e1>", "more", "commonly", "with", "a", "C1366332#ent", "<e2>"], "h": {"id": "C0030489", "name": "C0030489#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366332", "name": "C1366332#ent", "pos": [16, 17]}}
{"token": ["She", "had", "a", "previous", "diagnosis", "of", "a", "C0030489#ent", "<e1>", ",", "with", "a", "serum", "monoclonal", "band", "C1366332#ent", "<e2>", "anaemia", "being", "detected", "."], "h": {"id": "C0030489", "name": "C0030489#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366332", "name": "C1366332#ent", "pos": [15, 16]}}
{"token": ["Carotid", "artery", "stent", "placement", "C1413749#ent", "<e1>", ")", "may", "be", "associated", "with", "silent", "C0221505#ent", "<e2>"], "h": {"id": "C1413749", "name": "C1413749#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221505", "name": "C0221505#ent", "pos": [12, 13]}}
{"token": ["Lower", "concentrations", "of", "propranolol", "and", "C0025859#ent", "<e1>", "were", "needed", "to", "inhibit", "the", "C0237795#ent", "<e2>", "response", "than", "of", "sotalol", "or", "practolol", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [12, 13]}}
{"token": ["Now", ",", "new", "C0031727#ent", "<e1>", "that", "phosphorylate", "and", "inactivate", "C3538850#ent", "<e2>", "are", "being", "discovered", ",", "including", "MAPKAP", "kinase-2", ",", "a", "component", "of", "the", "p38", "stress-activated", "MAP", "kinase", "pathway"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538850", "name": "C3538850#ent", "pos": [9, 10]}}
{"token": ["Autosomal", "dominant", "polycystic", "kidney", "disease", "ADPKD", ")", "is", "the", "most", "common", "entity", "of", "C2931187#ent", "<e1>", "the", "kidney", "leading", "to", "C0035078#ent", "<e2>"], "h": {"id": "C2931187", "name": "C2931187#ent", "pos": [13, 14]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [19, 20]}}
{"token": ["We", "compared", "the", "effects", "of", "abrupt", "cessation", "of", "C0028066#ent", "<e1>", "and", "isosorbide", "dinitrate", "therapy", "patients", "with", "C0340288#ent", "<e2>"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [16, 17]}}
{"token": ["Possible", "regulation", "of", "the", "C1414402#ent", "<e1>", "cell", "response", "to", "injury", "via", "involvement", "of", "C1417123#ent", "<e2>", "is", "proposed", "."], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [13, 14]}}
{"token": ["Down-regulation", "of", "C1414402#ent", "<e1>", "indicates", "a", "potential", "for", "causing", "C1417123#ent", "<e2>", "expression", "and", "possibly", "for", "cadmium-induced", "carcinogenicity", "."], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [9, 10]}}
{"token": ["C1416851#ent", "<e1>", "II", "are", "ATP", "and", "Mg2", "+", "-dependent", "C3540017#ent", "<e2>", "with", "pH", "optima", "of", "7.8", "and", "8.0", "and", "isoelectric", "points", "6.9", "and", "7.6", ",", "respectively", "."], "h": {"id": "C1416851", "name": "C1416851#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [9, 10]}}
{"token": ["Also", ",", "DNA", "ligase", "II", "use", "ATP", "alpha", "S", "as", "a", "cofactor", "in", "the", "ligation", "reaction", "more", "efficiently", "than", "C1416851#ent", "<e1>", "further", "discriminating", "the", "ATP", "binding", "sites", "of", "these", "C3540017#ent", "<e2>", "."], "h": {"id": "C1416851", "name": "C1416851#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [29, 30]}}
{"token": ["The", "active", "non-glycosylated", "glucoamylase", ",", "C3889446#ent", "<e1>", "from", "the", "Saccharomycopsis", "fibuligera", "C1824750#ent", "<e2>", "Escherichia", "coli", "BL21(DE3", ")", ",", "has", "been", "purified", "from", "the", "solubilized", "inclusion", "bodies", "then", "renatured", "in", "vitro"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1824750", "name": "C1824750#ent", "pos": [11, 12]}}
{"token": ["Increased", "levels", "of", "IL-18", "also", "support", "C1423842#ent", "<e1>", "predominance", "in", "C0004943#ent", "<e2>"], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [10, 11]}}
{"token": ["Consistent", "with", "this", "conclusion", ",", "the", "effects", "of", "PtdIns-4,5-P2", "and", "PtdIns-3,4,5-P3", "were", "found", "to", "be", "inhibited", "at", "10", "mM", "C1333909#ent", "<e1>", "+", "and", "mimicked", "by", "high", "concentrations", "of", "C1425471#ent", "<e2>", "inositol", "hexasulfate"], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1425471", "name": "C1425471#ent", "pos": [28, 29]}}
{"token": ["Employing", "standard", "immunocytochemical", "techniques", "paraformaldehyde-fixed", "sagittal", "pars", "tuberalis", "and", "pars", "distalis", "sections", "were", "immunoreacted", "against", "luteinising", "hormone", "luteinising", "hormone", "beta-subunit", "C1336679#ent", "<e1>", "prolactin", ",", "growth", "hormone", "beta-endorphin", "and", "C1337111#ent", "<e2>"], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [28, 29]}}
{"token": ["The", "C0646939#ent", "<e1>", "inactivated", "in", "the", "presence", "of", "10", "mM", "ethylenediamine", "tetraacetic", "acid", "C0013618#ent", "<e2>", ")", "and", "65", "%", "of", "its", "native", "enzyme", "activity", "by", "the", "addition", "of", "20", "mM", "ZnCl2", "."], "h": {"id": "C0646939", "name": "C0646939#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [13, 14]}}
{"token": ["The", "two", "disaccharidases", "in", "brush", "border", "distinguished", "by", "the", "relative", "heat-stability", "of", "C1421114#ent", "<e1>", "compared", "with", "that", "of", "C0015278#ent", "<e2>", "."], "h": {"id": "C1421114", "name": "C1421114#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015278", "name": "C0015278#ent", "pos": [18, 19]}}
{"token": ["This", "result", "suggests", "that", "C0009763#ent", "<e1>", "in", "erythema", "infectiosum", "cause", "the", "C0085273#ent", "<e2>"], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085273", "name": "C0085273#ent", "pos": [11, 12]}}
{"token": ["Ataxia", "telangiectasia", "C4049625#ent", "<e1>", ")", ",", "Nijmegen", "breakage", "syndrome", "NBS", ")", ",", "and", "C1417250#ent", "<e2>", "fibroblasts", ",", "which", "lack", "an", "S", "checkpoint", "response", "exposed", "to", "ionizing", "radiation", "responded", "normally", "when", "exposed", "to", "UVC", "and", "inhibited", "replicon", "initiation", "."], "h": {"id": "C4049625", "name": "C4049625#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417250", "name": "C1417250#ent", "pos": [13, 14]}}
{"token": ["The", "C0006266#ent", "<e1>", "responded", "slowly", "to", "C0543495#ent", "<e2>", "and", "aminophylline", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [1, 2]}, "relation": "may_be_prevented_by", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [6, 7]}}
{"token": ["Twelve", "patients", "known", "to", "develop", "C0006266#ent", "<e1>", "with", "AP", "received", "200", "micrograms", "of", "C0543495#ent", "<e2>", "as", "premedication", "for", "all", "three", "nebulizers", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [13, 14]}}
{"token": ["The", "AMF", "is", "also", "identified", "as", "neuroleukin", "(", "C2975867#ent", "<e1>", ")", "and", "maturation", "factor", "MF", ")", "which", "are", "secreted", "phosphohexose", "isomerase", "C1333690#ent", "<e2>", ",", "PGI", ")", "from", "anaplastic", "cells"], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [21, 22]}}
{"token": ["Phosphoglucose", "isomerase", "C2975867#ent", "<e1>", ")", "is", "a", "glycolytic", "enzyme", "that", "exhibits", "extracellular", "cytokine", "activity", "C1333690#ent", "<e2>", "neuroleukin", ",", "and", "maturation", "factor", "that", "has", "been", "recently", "implicated", "as", "an", "autoantigen", "in", "rheumatoid", "arthritis"], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [14, 15]}}
{"token": ["Decorin", "immunostaining", "paralleled", "C1412792#ent", "<e1>", "immunostaining", "except", "that", "it", "was", "conspicuously", "absent", "in", "the", "C1258666#ent", "<e2>", "the", "plaque", "and", "markedly", "reduced", "in", "diffuse", "intimal", "thickenings", "."], "h": {"id": "C1412792", "name": "C1412792#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "EDRF", "is", "produced", "in", "the", "guinea", "pig", "pulmonary", "artery", "descending", "aorta", "birth", "and", "that", "EDRF", "is", "a", "mediator", "of", "the", "C3537240#ent", "<e1>", "actions", "of", "ACh", "and", "C1537501#ent", "<e2>", "."], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [29, 30]}}
{"token": ["We", "therefore", "tested", "the", "hypothesis", "that", "Ang-(1", "-", "7", ")", "potentiates", "the", "C3537240#ent", "<e1>", "or", "tissue", "plasminogen", "activator", "TPA", ")", "response", "to", "C1537501#ent", "<e2>", "in", "the", "human", "forearm", "vasculature"], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [22, 23]}}
{"token": ["The", "objectives", "of", "this", "study", "were", "to", "determine", "if", "EDRF", "is", "present", "in", "newborn", "vessels", "if", "EDRF", "mediates", "the", "C3537240#ent", "<e1>", "actions", "of", "ACh", "and", "C1537501#ent", "<e2>", "."], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [25, 26]}}
{"token": ["The", "Saccharomyces", "cerevisiae", "Dna2", ",", "which", "contains", "single-stranded", "DNA-specific", "endonuclease", "activity", "interacts", "C1516876#ent", "<e1>", "and", "physically", "with", "C1414583#ent", "<e2>", ",", "a", "structure-specific", "endonuclease", "in", "Okazaki", "fragment", "maturation", "during", "lagging", "strand", "synthesis", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414583", "name": "C1414583#ent", "pos": [17, 18]}}
{"token": ["Indexes", "of", "systolic", "and/or", "diastolic", "cardiac", "function", "also", "abnormal", "in", "KO", "mice", "E13.5", "and", "E17.5", ",", "in", "postnatal", "mice", "at", "C1418887#ent", "<e1>", ",", "and", "in", "C4284124#ent", "<e2>", "mice", "surviving", "to", "P28", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [25, 26]}}
{"token": ["C0039286#ent", "<e1>", "also", "significantly", "diminished", "C0001492#ent", "<e2>", "activity", "whereas", "the", "binding", "of", "hCG", "to", "receptor", "was", "not", "affected", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [5, 6]}}
{"token": ["A", "single", "injection", "of", "C0039286#ent", "<e1>", "to", "immature", "female", "quails", "induced", "a", "transient", "activation", "of", "C0001492#ent", "<e2>"], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [15, 16]}}
{"token": ["We", "suggest", "C0031977#ent", "<e1>", "has", "a", "potential", "anti-ataxic", "effect", "in", "human", "C0007758#ent", "<e2>", "used", "in", "considerably", "higher", "doses", "than", "those", "indicated", "for", "other", "purposes", "."], "h": {"id": "C0031977", "name": "C0031977#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [11, 12]}}
{"token": ["Like", "MPTP", ",", "2'-F-MPTP", "was", "exclusively", "oxidized", "by", "MAO-B", "and", "its", "toxicity", "blocked", "by", "C0282289#ent", "<e1>", "or", "deprenyl", "but", "not", "by", "C0009035#ent", "<e2>", "."], "h": {"id": "C0282289", "name": "C0282289#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009035", "name": "C0009035#ent", "pos": [21, 22]}}
{"token": ["We", "developed", "a", "novel", "approach", "to", "identify", "C1413702#ent", "<e1>", "targets", ",", "termed", "serial", "analysis", "chromatin", "occupancy", "(", "C1705548#ent", "<e2>", ")", ",", "by", "combining", "chromatin", "immunoprecipitation", "ChIP", ")", "with", "a", "modification", "of", "SAGE", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705548", "name": "C1705548#ent", "pos": [17, 18]}}
{"token": ["The", "requirement", "for", "C1333828#ent", "<e1>", "pathogenicity", "suggests", "a", "novel", "biological", "function", "this", "C3888277#ent", "<e2>", "."], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3888277", "name": "C3888277#ent", "pos": [12, 13]}}
{"token": ["The", "deduced", "amino", "acid", "sequence", "FS", "demonstrates", "extensive", "identity", "to", "three", "previously", "cloned", "C1333828#ent", "<e1>", ",", "including", "the", "enzymes", "responsible", "for", "synthesis", "of", "C3888277#ent", "<e2>", "B", "antigens"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3888277", "name": "C3888277#ent", "pos": [23, 24]}}
{"token": ["alpha3GT", "is", "a", "member", "of", "a", "family", "of", "metal-dependent", "retaining", "C1333828#ent", "<e1>", "including", "the", "C3888277#ent", "<e2>", "B", "synthases"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3888277", "name": "C3888277#ent", "pos": [14, 15]}}
{"token": ["Testing", "of", "current", "H5N1", "avian", "influenza", "virus", "isolates", ",", "the", "potential", "C0035064#ent", "<e1>", "of", "pandemic", "influenza", "suggests", "susceptibility", "to", "C0874161#ent", "<e2>", "and", "zanamivir", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0874161", "name": "C0874161#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "serine", "9", "phosphorylated", "by", "a", "PDB-sensitive", "kinase", ",", "likely", "C1259877#ent", "<e1>", "and", "that", "serine", "22", "to", "be", "C0669365#ent", "<e2>", "phosphorylated", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [21, 22]}}
{"token": ["Several", "basic", "C3275254#ent", "<e1>", "absent", "and", "the", "major", "C1424869#ent", "<e2>", "markedly", "reduced", "."], "h": {"id": "C3275254", "name": "C3275254#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1424869", "name": "C1424869#ent", "pos": [8, 9]}}
{"token": ["Pertinent", "clinical", "and", "laboratory", "data", "on", "admission", "that", "enabled", "the", "emergency", "physician", "suspect", "C1541923#ent", "<e1>", "systemic", "manifestations", "fever", ",", "malaise", "and", "C0003862#ent", "<e2>", "together", "with", "anemia", ",", "leukocytosis", "and", "hematuria", "."], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [21, 22]}}
{"token": ["In", "Experiment", "2", "we", "chose", "the", "maximum", "time", "point", "of", "C1527617#ent", "<e1>", "activation", "and", "assessed", "the", "effect", "of", "C0381241#ent", "<e2>", "(", "a", "specific", "C1527617#ent", "<e1>", "inhibitor", ")", "on", "regulation", "of", "cerebral", "vasospasm", "endothelial", "apoptosis"], "h": {"id": "C1527617", "name": "C1527617#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0381241", "name": "C0381241#ent", "pos": [18, 19]}}
{"token": ["In", "Saos2", ",", "C1527617#ent", "<e1>", "was", "tyrosine", "phosphorylated", "by", "GH", "stimulation", ",", "and", "C0381241#ent", "<e2>", ",", "a", "C1527617#ent", "<e1>", "specific", "inhibitor", ",", "inhibited", "GH-induced", "tyrosine", "phosphorylation", "FAK", "and", "actin", "stress", "fiber", "reorganization", "."], "h": {"id": "C1527617", "name": "C1527617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0381241", "name": "C0381241#ent", "pos": [13, 14]}}
{"token": ["Blocking", "C1527617#ent", "<e1>", "with", "the", "tyrphostin", "C0381241#ent", "<e2>", "led", "to", "some", "recycling", "of", "internalized", "Epo-Epo", "receptor", "complexes", "to", "the", "cell", "surface"], "h": {"id": "C1527617", "name": "C1527617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0381241", "name": "C0381241#ent", "pos": [6, 7]}}
{"token": ["Here", ",", "we", "have", "identified", "a", "C1335624#ent", "<e1>", "termed", "CARDIAK", "(", "for", "C1447644#ent", "<e2>", "ICE", ")", "associated", "kinase", ")", ",", "which", "contains", "a", "serine/threonine", "kinase", "domain", "a", "carboxy-terminal", "CARD"], "h": {"id": "C1335624", "name": "C1335624#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447644", "name": "C1447644#ent", "pos": [12, 13]}}
{"token": ["Compared", "with", "proximal", "segments", ",", "distal", "segments", "less", "responsive", "to", "C0699222#ent", "<e1>", "sodium", "nitroprusside", "equi-responsive", "to", "S-nitroso-N-acetylpenicillamine", ",", "and", "more", "responsive", "to", "C0282211#ent", "<e2>", "."], "h": {"id": "C0699222", "name": "C0699222#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [22, 23]}}
{"token": ["After", "the", "initial", "surgical", "correction", "C1420044#ent", "<e1>", "remained", "stable", "until", "follow-up", ",", "whereas", "C1427791#ent", "<e2>", "decreased", "again", "towards", "pre-operative", "values", "indicating", "a", "progressive", "deformity", "of", "the", "intervertebral", "disc", "space"], "h": {"id": "C1420044", "name": "C1420044#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1427791", "name": "C1427791#ent", "pos": [13, 14]}}
{"token": ["C0007194#ent", "<e1>", "the", "most", "common", "inherited", "C0018799#ent", "<e2>", "with", "sudden", "cardiac", "death", "a", "young", "age", "the", "most", "frequent", "cause", "of", "death", "in", "affected", "individuals", "."], "h": {"id": "C0007194", "name": "C0007194#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [6, 7]}}
{"token": ["Two", "adjacent", "C0079941#ent", "<e1>", "istA", "and", "istB", ",", "were", "located", "on", "one", "DNA", "strand", "C1366526#ent", "<e2>", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [14, 15]}}
{"token": ["The", "C0086376#ent", "<e1>", "have", "been", "named", "C1823140#ent", "<e2>", "and", "Ptx2b", "since", "they", "are", "highly", "related", "to", "Ptx1/P-OTX", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823140", "name": "C1823140#ent", "pos": [6, 7]}}
{"token": ["The", "increase", "in", "the", "oxidation", "of", "fats", "and", "C0086376#ent", "<e1>", "is", "the", "most", "important", "mechanisms", "in", "C1823140#ent", "<e2>", "in", "these", "patients", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1823140", "name": "C1823140#ent", "pos": [16, 17]}}
{"token": ["This", "study", "was", "conducted", "to", "evaluate", "the", "effects", "of", "oral", "clonidine", "and", "tizanidine", ",", "C2746076#ent", "<e1>", "as", "premedication", "for", "C0039629#ent", "<e2>", "spinal", "anesthesia", "63", "gynecological", "patients", "."], "h": {"id": "C2746076", "name": "C2746076#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039629", "name": "C0039629#ent", "pos": [19, 20]}}
{"token": ["To", "investigate", "the", "possible", "benefits", "and", "adverse", "effects", "the", "addition", "of", "C0939237#ent", "<e1>", "to", "a", "standard", "treatment", "protocol", "the", "treatment", "of", "severe", "C0035222#ent", "<e2>"], "h": {"id": "C0939237", "name": "C0939237#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [22, 23]}}
{"token": ["Studies", "with", "deletion", "mutants", "of", "C1835417#ent", "<e1>", "indicated", "that", "the", "C-terminal", "domain", "Abl", "within", "C1835417#ent", "<e1>", "was", "involved", "in", "complex", "formation", "with", "C1527617#ent", "<e1>", "."], "h": {"id": "C1835417", "name": "C1835417#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1527617", "name": "C1527617#ent", "pos": [22, 23]}}
{"token": ["While", "it", "is", "clear", "that", "ACE", "inhibitors", "reduce", "the", "progression", "of", "C0011881#ent", "<e1>", "evidence", "suggests", "that", "C0596110#ent", "<e2>", "may", "be", "just", "as", "effective", "."], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [16, 17]}}
{"token": ["Comparison", "of", "brain", "homogenates", "from", "C2987364#ent", "<e1>", "and", "cyp1b1-null", "mice", "revealed", "that", "C1417108#ent", "<e2>", "6-hydroxylation", "was", "clearly", "mediated", "to", "a", "significant", "degree", "by", "CYP1B1", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417108", "name": "C1417108#ent", "pos": [12, 13]}}
{"token": ["The", "cell", "growth", "curves", "that", "the", "over-expression", "of", "C2987364#ent", "<e1>", "p53", "gene", "significantly", "suppressed", "the", "growth", "of", "C1417108#ent", "<e2>", ",", "with", "G(0)-G(1", ")", "arrest", "and", "apoptosis", "shown", "by", "flow", "cytometric", "assays", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417108", "name": "C1417108#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "losartan", "'s", "inhibition", "of", "AngII", "'s", "effects", "on", "the", "C0069919#ent", "<e1>", "consistent", "with", "key", "role", "for", "these", "C0086376#ent", "<e2>", "in", "processes", "linking", "occupation", "of", "the", "AT1", "receptor", "stimulation", "of", "aldosterone", "synthesis"], "h": {"id": "C0069919", "name": "C0069919#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [20, 21]}}
{"token": ["In", "vitro", "transcription-translation", "of", "p56", "and", "C0069919#ent", "<e1>", "cDNAs", "generated", "C0086376#ent", "<e2>", "of", "56", "and", "30", "kDa", ",", "respectively", "."], "h": {"id": "C0069919", "name": "C0069919#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["Intracellular", "viral", "proteins", "detected", "by", "immunoprecipitation", "of", "pulse-labeled", "cell", "extracts", "with", "monospecific", "sera", "raised", "against", "C0069919#ent", "<e1>", ",", "p16", ",", "and", "gp135", "and", "resolution", "of", "the", "C0086376#ent", "<e2>", "by", "sodium", "dodecyl", "sulfate-polyacrylamide", "gel", "electrophoresis"], "h": {"id": "C0069919", "name": "C0069919#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [26, 27]}}
{"token": ["It", "is", "concluded", "that", "C1832175#ent", "<e1>", "+", "in", "arterial", "blood", "patients", "with", "C0008679#ent", "<e2>", "correlated", "with", "acid-base", "and", "gas", "quantities", "an", "entirely", "different", "manner", "to", "that", "observed", "in", "acute", "acid-base", "disturbances", "in", "normal", "adults"], "h": {"id": "C1832175", "name": "C1832175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [12, 13]}}
{"token": ["Specific", "C0003295#ent", "<e1>", "(", "eg", ",", "naloxone", ",", "flumazenil", ",", "C0010620#ent", "<e2>", "and", "benzodiazepines", ")", "are", "available", "for", "the", "management", "of", "certain", "recreational", "drug-induced", "toxicities"], "h": {"id": "C0003295", "name": "C0003295#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010620", "name": "C0010620#ent", "pos": [10, 11]}}
{"token": ["Treatment", "of", "these", "side", "effects", "both", "general", "strategies", "and", "specific", "C0003295#ent", "<e1>", ",", "such", "as", "C0010620#ent", "<e2>", ",", "yohimbine", ",", "dopamine", "agonists", "and", "buspirone", "."], "h": {"id": "C0003295", "name": "C0003295#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010620", "name": "C0010620#ent", "pos": [15, 16]}}
{"token": ["C3714506#ent", "<e1>", "MGS", ")", ",", "an", "autosomal", "recessive", "disorder", "by", "posterior", "encephalocoele", "C3714581#ent", "<e2>", "post-axial", "polydactyly", "be", "recognised", "by", "obstetricians", "and", "paediatricians", "to", "counsel", "parents", "regarding", "the", "25", "%", "recurrence", "risk"], "h": {"id": "C3714506", "name": "C3714506#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3714581", "name": "C3714581#ent", "pos": [12, 13]}}
{"token": ["A", "41-year-old", "woman", "who", "presented", "with", "purpura", ",", "glomerulonephritis", "and", "C0543697#ent", "<e1>", "found", "subsequently", "to", "have", "developed", "C0034362#ent", "<e2>"], "h": {"id": "C0543697", "name": "C0543697#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034362", "name": "C0034362#ent", "pos": [17, 18]}}
{"token": ["The", "Melkersson-Rosenthal", "syndrome", "of", "recurrent", "swelling", "the", "C3889123#ent", "<e1>", "or", "face", ",", "intermittent", "C0015469#ent", "<e2>", "and", "fissured", "tongue"], "h": {"id": "C3889123", "name": "C3889123#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015469", "name": "C0015469#ent", "pos": [13, 14]}}
{"token": ["Patient", "1", "with", "intermittent", "severe", "lip", "edema", "and", "patient", "2", "with", "C3889123#ent", "<e1>", "and", "facial", "swelling", "with", "C0015469#ent", "<e2>"], "h": {"id": "C3889123", "name": "C3889123#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015469", "name": "C0015469#ent", "pos": [17, 18]}}
{"token": ["Studies", "on", "molecular", "mechanisms", "leukotrienes", "action", "have", "led", "to", "the", "development", "and", "patents", "of", "potential", "drugs", "including", "new", "5-lipoxygenase", "inhibitors", "C1412362#ent", "<e1>", "FLAP", ")", "inhibitors", ",", "C0595726#ent", "<e2>", "or", "nanoparticulate", "leukotriene", "receptor", "antagonist", "formulations", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0595726", "name": "C0595726#ent", "pos": [26, 27]}}
{"token": ["The", "powerful", "sebosuppressive", "effect", "of", "some", "C0035339#ent", "<e1>", ",", "such", "as", "C0022265#ent", "<e2>", "demonstrates", "that", "sebocyte", "differentiation", "is", "altered", "by", "C0035339#ent", "<e1>", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [6, 7]}, "relation": "structural_class_of", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [11, 12]}}
{"token": ["The", "proliferation", "of", "isolated", "sebocytes", "is", "inhibited", "by", "C0035339#ent", "<e1>", ",", "such", "as", "C0022265#ent", "<e2>", "and", "tretinoin", ",", "which", "are", "known", "to", "be", "clinically", "active", "in", "human", "acne", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [8, 9]}, "relation": "structural_class_of", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [13, 14]}}
{"token": ["The", "C0003374#ent", "<e1>", "quinacrine", ",", "quinine", "and", "C0282398#ent", "<e2>", ",", "as", "well", "as", "the", "structurally-similar", "compound", ",", "W-7", ",", "inhibit", "calcium-dependent", "backward", "swimming", "and", "calcium", "currents", "Paramecium", "calkinsi"], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0282398", "name": "C0282398#ent", "pos": [7, 8]}}
{"token": ["Ovarian", "levels", "of", "the", "antioxidant", "tripeptide", "glutathione", "(", "C1260386#ent", "<e1>", ")", "increase", "following", "C3536870#ent", "<e2>", "administration", ",", "suggesting", "that", "C1260386#ent", "<e1>", "synthesis", "in", "the", "ovary", "may", "be", "associated", "with", "follicular", "growth"], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536870", "name": "C3536870#ent", "pos": [13, 14]}}
{"token": ["Anti-sst1", "labelled", "beaded", "fibres", "sst2(A", ")", ",", "sst2(B", ")", ",", "C0210233#ent", "<e1>", "and", "sst5", "gave", "somatodendritic", "labelling", "and", "C2982407#ent", "<e2>", "labelled", "presumptive", "neuronal", "cilia", "."], "h": {"id": "C0210233", "name": "C0210233#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2982407", "name": "C2982407#ent", "pos": [18, 19]}}
{"token": ["In", "normal", "kidney", "tissue", ",", "podocytes", "and", "mesangial", "cells", "the", "glomeruli", "stained", "for", "sst1", ",", "sst2B", ",", "C0210233#ent", "<e1>", "and", "sst5", ",", "and", "stained", "weakly", "for", "C2982407#ent", "<e2>", "."], "h": {"id": "C0210233", "name": "C0210233#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2982407", "name": "C2982407#ent", "pos": [26, 27]}}
{"token": ["Many", "cases", "variously", "reported", "as", "Wagner's", "disease", "C0035305#ent", "<e1>", "hyaloideoretinopathy", "with", "cleft", "palate", "and", "the", "Pierre", "Robin", "syndrome", "were", "the", "C2020284#ent", "<e2>"], "h": {"id": "C0035305", "name": "C0035305#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C2020284", "name": "C2020284#ent", "pos": [20, 21]}}
{"token": ["We", "discovered", "that", "the", "fusion", "partner", "ETO", "binds", "to", "the", "human", "C1334043#ent", "<e1>", "of", "the", "murine", "nuclear", "receptor", "corepressor", "C1334870#ent", "<e2>", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334870", "name": "C1334870#ent", "pos": [19, 20]}}
{"token": ["N-CoR", "protein", "are", "regulated", "by", "mSiah2", ",", "a", "mammalian", "C1334043#ent", "<e1>", "of", "Drosophila", "Seven", "in", "absentia", "that", "targets", "C1334870#ent", "<e2>", "for", "proteasomal", "degradation"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334870", "name": "C1334870#ent", "pos": [18, 19]}}
{"token": ["The", "following", "anticoagulants", "were", "investigated", ":", "C0142825#ent", "<e1>", "sodium", "oxalate", "buffered", "citrate", "potassium", "oxalate/sodium", "fluoride", ";", "C0037513#ent", "<e2>", "and", "potassium", "EDTA"], "h": {"id": "C0142825", "name": "C0142825#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037513", "name": "C0037513#ent", "pos": [16, 17]}}
{"token": ["The", "C1704927#ent", "<e1>", "this", "family", "was", "designated", "C1417282#ent", "<e2>", "."], "h": {"id": "C1704927", "name": "C1704927#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417282", "name": "C1417282#ent", "pos": [7, 8]}}
{"token": ["The", "binding", "of", "a", "C1436406#ent", "<e1>", "CANP", ")", "with", "high", "calcium", "sensitivity", "C1413109#ent", "<e2>", ")", "to", "erythrocyte", "membranes", "its", "subsequent", "autolytic", "activation", "the", "membranes", "were", "analyzed", "by", "an", "immunoblot", "technique"], "h": {"id": "C1436406", "name": "C1436406#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413109", "name": "C1413109#ent", "pos": [12, 13]}}
{"token": ["Antibodies", "raised", "against", "synthetic", "peptides", "to", "match", "the", "N-terminal", "sequences", "the", "pre-", "and", "post-autolysis", "forms", "of", "the", "C1436406#ent", "<e1>", "specifically", "with", "the", "corresponding", "form", "of", "C1413109#ent", "<e2>", "and", "not", "with", "the", "other", "."], "h": {"id": "C1436406", "name": "C1436406#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413109", "name": "C1413109#ent", "pos": [25, 26]}}
{"token": ["M-CSF", "therefore", "functions", "to", "promote", "C4084905#ent", "<e1>", "activation", "as", "a", "novel", "MEK-independent", "C1706586#ent", "<e2>", "target", "to", "control", "Survivin-mediated", "osteoclast", "survival", "."], "h": {"id": "C4084905", "name": "C4084905#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "Aeromonas", "bacteremia", "cause", "a", "rapidly", "fatal", "outcome", "and", "should", "be", "considered", "an", "important", "pathogen", "for", "C0036690#ent", "<e1>", "in", "patients", "with", "C0023890#ent", "<e2>", "neoplasm", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [23, 24]}}
{"token": ["Methicillin-resistant", "Staphylococcus", "aureus", "MRSA", ")", "is", "an", "important", "cause", "of", "C0036690#ent", "<e1>", "in", "patients", "with", "C0023890#ent", "<e2>", "and", "after", "liver", "transplantation"], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "glucagon", "may", "be", "important", "in", "mediating", "the", "C0020456#ent", "<e1>", "associated", "with", "administration", "of", "C0043366#ent", "<e2>", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0043366", "name": "C0043366#ent", "pos": [15, 16]}}
{"token": ["Administration", "of", "Saffan", "evoked", "more", "C0020456#ent", "<e1>", "than", "a", "mixture", "with", "C0043366#ent", "<e2>", ",", "or", "C0043366#ent", "<e2>", "alone", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0043366", "name": "C0043366#ent", "pos": [11, 12]}}
{"token": ["The", "large", "number", "of", "A.", "thaliana", "genes", "encoding", "C0031727#ent", "<e1>", "might", "have", "been", "achieved", "through", "successive", "rounds", "of", "C0079429#ent", "<e2>", "and", "genome", "duplications"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}}
{"token": ["C2987236#ent", "<e1>", "is", "a", "novel", "C1335807#ent", "<e2>", "the", "Ig", "superfamily", "is", "most", "similar", "to", "FPRP", "."], "h": {"id": "C2987236", "name": "C2987236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335807", "name": "C1335807#ent", "pos": [5, 6]}}
{"token": ["Two", "young", "patients", "with", "C1867743#ent", "<e1>", "association", "with", "C0020445#ent", "<e2>", "unstable", "angina", "in", "the", "second", "trimester", "of", "pregnancy", "."], "h": {"id": "C1867743", "name": "C1867743#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [8, 9]}}
{"token": ["Our", "report", "describes", "an", "uncommon", "presentation", "of", "unstable", "angina", "pregnancy", "in", "2", "young", "women", "with", "C1867743#ent", "<e1>", "aortic", "valvular", "supravalvular", "stenosis", "a", "result", "of", "C0020445#ent", "<e2>"], "h": {"id": "C1867743", "name": "C1867743#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "83", "children", "with", "no", "family", "history", "C1867743#ent", "<e1>", "hypercholesterolemia", ",", "were", "diagnosed", "with", "inherited", "hyperlipidemia", "25", "with", "C0020445#ent", "<e2>", "and", "58", "with", "familial", "combined", "hyperlipidemia", "."], "h": {"id": "C1867743", "name": "C1867743#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [20, 21]}}
{"token": ["The", "structure-specific", "recognition", "protein", "C1420432#ent", "<e1>", "plays", "a", "role", "in", "transcription", "and", "replication", "in", "the", "C0008546#ent", "<e2>", "context", "."], "h": {"id": "C1420432", "name": "C1420432#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [15, 16]}}
{"token": ["High", "field", "intensity", "MRI", "may", "demonstrate", "signal", "abnormalities", "consistent", "with", "deposits", "of", "C1166521#ent", "<e1>", "or", "other", "paramagnetic", "substances", "in", "several", "C0015371#ent", "<e2>"], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [20, 21]}}
{"token": ["MR", "imaging", "the", "brain", ",", "particularly", "with", "high", "field", "MR", "imagers", ",", "may", "demonstrate", "signal", "abnormalities", "consistent", "with", "deposits", "of", "C1166521#ent", "<e1>", "or", "other", "paramagnetic", "substances", "in", "C0015371#ent", "<e2>"], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [27, 28]}}
{"token": ["Circulating", "and", "C1420295#ent", "<e1>", "monocytes/macrophages", ",", "through", "production", "of", "hydrolytic", "C3540790#ent", "<e2>", "and", "growth", "factors", "can", "dramatically", "affect", "the", "local", "tissue", "environment", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [10, 11]}}
{"token": ["Mi", "can", "also", "activate", "transcription", "through", "recognition", "of", "the", "M", "box", "a", "highly", "conserved", "pigmentation", "gene", "element", ",", "and", "may", "thereby", "determine", "C1420295#ent", "<e1>", "expression", "of", "pigmentation", "C3540790#ent", "<e2>", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [27, 28]}}
{"token": ["These", "changes", "reflected", "analogous", "dissimilar", "effects", "of", "C0014442#ent", "<e1>", "inducers", "on", "the", "metabolism", "of", "the", "exogenous", "cytochrome", "P-450", "substrates", "C0065601#ent", "<e2>", ",", "acetanilide", ",", "benzo[alpha]pyrene", "and", "ethylmorphine", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0065601", "name": "C0065601#ent", "pos": [19, 20]}}
{"token": ["alpha-Amylases", "are", "widely", "distributed", "C0014442#ent", "<e1>", "that", "initiate", "the", "hydrolysis", "of", "starch", "into", "low", "molecular", "weight", "C0065601#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0065601", "name": "C0065601#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "cyclosporin", "A", "CSA", ")", "or", "methotrexate", "(", "C0025677#ent", "<e1>", ")", "in", "the", "C1333196#ent", "<e2>", "mediated", "regulation", "of", "CD69", "was", "analyzed", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [15, 16]}}
{"token": ["C1639494#ent", "<e1>", "is", "commonly", "used", "for", "the", "prophylaxis", "of", "C1535939#ent", "<e2>", "patients", "with", "a", "diagnosis", "of", "HIV", "infection", "have", "allergies", "to", "sulfa-based", "drugs", "."], "h": {"id": "C1639494", "name": "C1639494#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [9, 10]}}
{"token": ["Trimethoprim", "and", "C1639494#ent", "<e1>", "are", "commonly", "used", "in", "the", "management", "of", "C1535939#ent", "<e2>", "HIV-infected", "patients", "."], "h": {"id": "C1639494", "name": "C1639494#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [11, 12]}}
{"token": ["Scleredema", "of", "C0010414#ent", "<e1>", "is", "an", "uncommon", "dermatosis", "characterized", "by", "thickened", ",", "C0241075#ent", "<e2>", "sometimes", "with", "erythema", "."], "h": {"id": "C0010414", "name": "C0010414#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0241075", "name": "C0241075#ent", "pos": [12, 13]}}
{"token": ["These", "reagents", "will", "allow", "us", "to", "determine", "whether", "HER3", "binds", "C1332109#ent", "<e1>", "or", "other", "growth", "regulatory", "proteins", "what", "role", "C0812265#ent", "<e2>", "in", "the", "regulation", "of", "cell", "growth"], "h": {"id": "C1332109", "name": "C1332109#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812265", "name": "C0812265#ent", "pos": [19, 20]}}
{"token": ["C3280574#ent", "<e1>", "PAP", ")", "is", "an", "C0021390#ent", "<e2>", "by", "neutralizing", "autoantibodies", "granulocyte-macrophage", "colony", "stimulating", "factor", "GM-CSF", ")", "."], "h": {"id": "C3280574", "name": "C3280574#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [6, 7]}}
{"token": ["The", "most", "logical", "explanation", "for", "these", "results", "is", "that", "the", "mutant", "cells", "a", "structurally", "altered", "C0297817#ent", "<e1>", "activity", "is", "less", "sensitive", "to", "inhibition", "by", "hydroxyurea", "or", "C0018316#ent", "<e2>", "."], "h": {"id": "C0297817", "name": "C0297817#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018316", "name": "C0018316#ent", "pos": [26, 27]}}
{"token": ["A", "randomised", ",", "double-blind", "study", "performed", "to", "assess", "the", "efficacy", "and", "tolerability", "of", "C1176415#ent", "<e1>", "in", "patients", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C1176415", "name": "C1176415#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [20, 21]}}
{"token": ["Sleeping", "illness", "C0027333#ent", "<e1>", "are", "lacking", ",", "as", "well", "as", "rabies", ",", "C0043395#ent", "<e2>", "Fasciola", "hepatica", "Echinococcus", "granulosus", "Hymenolepis", "nana", "Trichinella", "spiralis", "Dracunculus", "medinensis"], "h": {"id": "C0027333", "name": "C0027333#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0043395", "name": "C0043395#ent", "pos": [12, 13]}}
{"token": ["However", ",", "three", "cases", "of", "C3203102#ent", "<e1>", "observed", "in", "the", "C0021246#ent", "<e2>", "group", "."], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [10, 11]}}
{"token": ["The", "examinations", "have", "shown", "that", "C0041912#ent", "<e1>", "and", "ergometrine", "tests", "of", "informative", "value", "the", "diagnosis", "of", "C0002963#ent", "<e2>"], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [16, 17]}}
{"token": ["The", "study", "was", "undertaken", "to", "examine", "the", "informative", "value", "C0041912#ent", "<e1>", "(", "chloroethyl", ")", "and", "ergometrine", "tests", "the", "diagnosis", "of", "C0002963#ent", "<e2>"], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [20, 21]}}
{"token": ["SAPKK-4", "and", "SAPKK-5", "were", "also", "eluted", "from", "Mono", "S", "higher", "NaC1", "concentrations", "than", "C1434650#ent", "<e1>", "and", "these", "enzymes", "activated", "C1420017#ent", "<e2>", "kinase-1", "but", "not", "C1420017#ent", "<e2>", "kinase-2", "."], "h": {"id": "C1434650", "name": "C1434650#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420017", "name": "C1420017#ent", "pos": [19, 20]}}
{"token": ["The", "75", "C0059256#ent", "<e1>", ",", "indeed", ",", "strongly", "recognized", "in", "patients", "with", "adult", "C0031090#ent", "<e2>"], "h": {"id": "C0059256", "name": "C0059256#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [13, 14]}}
{"token": ["This", "reduction", "is", "also", "inhibited", "by", "potassium", "cyanide", "menadione", ",", "and", "C0033405#ent", "<e1>", ",", "as", "well", "as", "by", "additional", "C1257954#ent", "<e2>", "cimetidine", "and", "chlorpromazine", "."], "h": {"id": "C0033405", "name": "C0033405#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [19, 20]}}
{"token": ["The", "preclinical", "and", "clinical", "characterization", "of", "C0877869#ent", "<e1>", "demonstrated", "the", "potential", "for", "the", "use", "of", "this", "C1254351#ent", "<e2>", "as", "a", "component", "of", "a", "polytherapeutic", "treatment", "strategy", "to", "prevent", "the", "rejection", "of", "organ", "grafts"], "h": {"id": "C0877869", "name": "C0877869#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}}
{"token": ["C0877869#ent", "<e1>", "a", "novel", "C1254351#ent", "<e2>", ",", "known", "to", "inhibit", "dihydroorotic", "acid", "dehydrogenase", "DHO-DH", ")", ",", "resulting", "in", "a", "decrease", "of", "the", "pyrimidine", "de", "novo", "synthesis", "."], "h": {"id": "C0877869", "name": "C0877869#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}}
{"token": ["DYRK", "family", "member", "C1414204#ent", "<e1>", "(", "Minibrain", ")", "was", "also", "found", "to", "co-precipitate", "with", "C1704461#ent", "<e2>", "and", "TRX", ",", "associations", "that", "did", "not", "require", "the", "C-terminus", "of", "the", "molecule", "."], "h": {"id": "C1414204", "name": "C1414204#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704461", "name": "C1704461#ent", "pos": [14, 15]}}
{"token": ["C1426958#ent", "<e1>", "repression", "is", "dominant", "over", "NRF2-mediated", "C1415619#ent", "<e2>", "transcription", "and", "inactivation", "of", "C1426958#ent", "<e1>", "is", "a", "prerequisite", "for", "C1415619#ent", "<e2>", "induction", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1426958", "name": "C1426958#ent", "pos": [0, 1]}}
{"token": ["Fifty", "patients", "with", "C0030305#ent", "<e1>", "studied", "prospectively", "to", "assess", "the", "diagnostic", "value", "Radionuclide", "Biliary", "Scanning", "C0392475#ent", "<e2>", ")", "performed", "within", "72", "hours", "of", "an", "attack", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0392475", "name": "C0392475#ent", "pos": [15, 16]}}
{"token": ["These", "results", "would", "indicate", "the", "usefulness", "of", "a", "phase", "II", "study", "epirubicin", "at", "the", "dose", "of", "90", "mg/m2", "in", "association", "with", "conventional", "dose", "C0377401#ent", "<e1>", "with", "the", "support", "of", "C1705750#ent", "<e2>", "in", "advanced", "NSCLC", "."], "h": {"id": "C0377401", "name": "C0377401#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1705750", "name": "C1705750#ent", "pos": [29, 30]}}
{"token": ["C1335280#ent", "<e1>", "(", "P", "<", "0.03", ")", "and", "C1335281#ent", "<e2>", "(", "P", "<", "0.03", ")", "increased", "only", "in", "SM/SP", "with", "no", "change", "in", "PTEN", "in", "CM/SP", "and", "SM/SP", "groups", "."], "h": {"id": "C1335280", "name": "C1335280#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335281", "name": "C1335281#ent", "pos": [8, 9]}}
{"token": ["We", "have", "identified", "the", "phenylhydrazonopyrazolone", "sulfonate", "as", "a", "potent", "and", "cell-permeable", "inhibitor", ",", "which", "is", "specific", "for", "C1335280#ent", "<e1>", "over", "the", "closely", "related", "tyrosine", "phosphatases", "Shp1", "and", "C1335281#ent", "<e2>", "."], "h": {"id": "C1335280", "name": "C1335280#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1335281", "name": "C1335281#ent", "pos": [27, 28]}}
{"token": ["The", "most", "frequent", "medical", "events", "related", "to", "gastrointestinal", "problems", "consisted", "of", "transient", "C0011991#ent", "<e1>", "three", "subjects", "in", "the", "single-dose", "study", "and", "C0578159#ent", "<e2>", "one", "subject", "in", "the", "multiple-dose", "study", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0578159", "name": "C0578159#ent", "pos": [21, 22]}}
{"token": ["Several", "studies", "have", "shown", "that", "probiotics", "are", "of", "benefit", "in", "gastrointestinal", "infections", "including", "C0011991#ent", "<e1>", "Clostridium", "difficile-associated", "diarrhea", ",", "traveler's", "diarrhea", "and", "C0578159#ent", "<e2>"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0578159", "name": "C0578159#ent", "pos": [22, 23]}}
{"token": ["DIDS", ",", "C0049330#ent", "<e1>", ",", "or", "methazolamide", "had", "little", "effect", "on", "C1416914#ent", "<e2>", "in", "response", "to", "high", "concentration", "PGE(2", ")", "(", "100", "microg/ml", ")", "."], "h": {"id": "C0049330", "name": "C0049330#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416914", "name": "C1416914#ent", "pos": [11, 12]}}
{"token": ["Amprenavir", ",", "nelfinavir", ",", "and", "C0376637#ent", "<e1>", "appear", "to", "inhibit", "C1142644#ent", "<e2>", "to", "a", "moderate", "extent", ",", "suggesting", "a", "selected", "number", "of", "coadministration", "restrictions", "."], "h": {"id": "C0376637", "name": "C0376637#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [10, 11]}}
{"token": ["At", "this", "concentration", ",", "C0376637#ent", "<e1>", "completely", "inhibited", "the", "formation", "of", "3-methoxymorphinan", "by", "C1142644#ent", "<e2>", "and", "rCYP3A5", "."], "h": {"id": "C0376637", "name": "C0376637#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "we", "demonstrate", "that", "CCM3", "(", "C1418402#ent", "<e1>", ")", "coprecipitates", "and", "colocalizes", "with", "C1427709#ent", "<e2>", "."], "h": {"id": "C1418402", "name": "C1418402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1427709", "name": "C1427709#ent", "pos": [16, 17]}}
{"token": ["C0059438#ent", "<e1>", "are", "the", "natural", "flavonoids", "known", "inhibitory", "activity", "toward", "C0030065#ent", "<e2>", "with", "a", "potential", "to", "be", "utilized", "in", "disease", "prevention", "treatment", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030065", "name": "C0030065#ent", "pos": [10, 11]}}
{"token": ["Conversely", ",", "down-regulation", "of", "C1417874#ent", "<e1>", "by", "siRNA", "increases", "cellular", "levels", "C1364818#ent", "<e2>", "."], "h": {"id": "C1417874", "name": "C1417874#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [11, 12]}}
{"token": ["Precipitation", "of", "partially", "purified", "C1334133#ent", "<e1>", "glutathione", "S-transferase", "fusion", "proteins", "the", "N-terminal", "SH2", "domains", "p85", "and", "C2984553#ent", "<e2>", "and", "both", "SH2", "domains", "Syp", "was", "demonstrated", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2984553", "name": "C2984553#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "we", "conclude", "that", "p85", "and", "Syp", "bind", "to", "the", "C1334133#ent", "<e1>", "tyrosine", "1322", "and", "C2984553#ent", "<e2>", "binds", "to", "the", "insulin", "receptor", "NPXY", "domain", "at", "tyrosine", "960", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2984553", "name": "C2984553#ent", "pos": [16, 17]}}
{"token": ["Diagnosis", "begins", "with", "a", "classification", "based", "on", "major", "clinical", "findings", "genital", "ulcers", "lymphadenitis", ",", "C0311389#ent", "<e1>", ",", "vaginal", "discharge", "pelvic", "inflammatory", "disease", "and", "male", "C0039082#ent", "<e2>"], "h": {"id": "C0311389", "name": "C0311389#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [24, 25]}}
{"token": ["The", "F", "box", "protein", "beta-TrCP1", "the", "doubly", "phosphorylated", "DpSGphiXpS", "destruction", "motif", ",", "present", "in", "beta-catenin", "and", "C0663914#ent", "<e1>", ",", "and", "directs", "the", "C1412851#ent", "<e2>", ")", "to", "ubiquitinate", "these", "proteins", "at", "specific", "lysines", "."], "h": {"id": "C0663914", "name": "C0663914#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412851", "name": "C1412851#ent", "pos": [22, 23]}}
{"token": ["C0006863#ent", "<e1>", "or", "vehicle", "after", "C0752308#ent", "<e2>", "(", "HI", ":", "temporary", "occlusion", "of", "both", "carotid", "arteries", "hypoxia", ")", "."], "h": {"id": "C0006863", "name": "C0006863#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752308", "name": "C0752308#ent", "pos": [5, 6]}}
{"token": ["as", "C1413394#ent", "<e1>", ")", "and", "its", "effect", "on", "quality", "of", "life", "C0518214#ent", "<e2>", ")", "in", "patients", "after", "coronary", "artery", "bypass", "grafting", "CABG", ")", "."], "h": {"id": "C1413394", "name": "C1413394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0518214", "name": "C0518214#ent", "pos": [11, 12]}}
{"token": ["After", "cytoplasmic", "over", "expression", "in", "Escherichia", "coli", "renaturation", ",", "the", "activation", "properties", "of", "C0960371#ent", "<e1>", "studied", "and", "compared", "to", "those", "of", "C1418965#ent", "<e2>", "also", "called", "as", "human", "cationic", "trypsinogen", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418965", "name": "C1418965#ent", "pos": [21, 22]}}
{"token": ["In", "the", "presence", "of", "HCO3-/CO2", "(", "pH", "7.35", ")", ",", "C0026249#ent", "<e1>", "and", "phorbol", "esters", "to", "induce", "a", "detectable", "rise", "in", "C1333690#ent", "<e2>", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [21, 22]}}
{"token": ["C0025744#ent", "<e1>", "(", "methyldopa", "(", "ethyl", "ester", ")", ",", "carbidopa", ",", "C0009014#ent", "<e2>", ",", "and", "ST-91", "were", "evaluated", "for", "their", "effects", "on", "conditioned", "salivation", "unanesthetized", "dogs", "."], "h": {"id": "C0025744", "name": "C0025744#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [11, 12]}}
{"token": ["Immunoblot", "analysis", "type", "II", "pneumocyte", ",", "cellular", "lysate", "and", "C3889469#ent", "<e1>", "revealed", "two", "bands", "at", "46", "and", "48", "C1839259#ent", "<e2>", ",", "consistent", "with", "apparent", "molecular", "masses", "Mr", ")", "reported", "for", "rat", "PAI-1", "from", "HTC", "hepatoma", "cells", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [18, 19]}}
{"token": ["Elution", "with", "C0012695#ent", "<e1>", "specifically", "released", "C1305923#ent", "<e2>", "with", "apparent", "molecular", "masses", "420", "and", "39", "kD.", "In", "some", "preparations", ",", "small", "amounts", "a", "90-kD", "polypeptide", "were", "observed", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [6, 7]}}
{"token": ["We", "investigated", "the", "influence", "of", "dietary", "protein", "on", "the", "C1539479#ent", "<e1>", "of", "methylmercury", "(", "MeHg", ")", ",", "the", "tissue", "glutathione", "C1260386#ent", "<e2>", ")", "levels", "and", "the", "efflux", "rates", "C1260386#ent", "<e2>", "in", "C57BL/6N", "male", "mice", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "provide", "direct", "evidence", "for", "understanding", "the", "C1539479#ent", "<e1>", "of", "oxygen-sensitive", "metabolic", "deactivation", "of", "MC", "by", "C1260386#ent", "<e2>", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [17, 18]}}
{"token": ["Because", "C1260386#ent", "<e1>", "functions", "in", "the", "removal", "of", "free", "radicals", "and", "lipid", "peroxidation", "a", "free", "radical-initiated", "process", "that", "occurs", "in", "the", "ischemic", "kidney", "we", "investigated", "the", "C1539479#ent", "<e2>", "of", "this", "C1260386#ent", "<e1>", "pool", "in", "the", "ischemic", "kidney"], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [1, 2]}}
{"token": ["The", "number", "of", "individuals", "infected", "with", "C3854222#ent", "<e1>", "HIV", ")", "and", "other", "pathogens", "causing", "C0036918#ent", "<e2>", "STDs", ")", "is", "growing", "dramatically", "worldwide", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036918", "name": "C0036918#ent", "pos": [14, 15]}}
{"token": ["Heterozygous", "mutations", "the", "tissue-specific", "transcription", "factor", "hepatocyte", "nuclear", "factor", "(HNF)1beta", ",", "cause", "maturity", "onset", "C0011849#ent", "<e1>", "of", "the", "young", "(", "C0431693#ent", "<e2>", ")", "and", "kidney", "anomalies", "agenesis", ",", "hypoplasia", ",", "dysplasia", "and", "cysts", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0431693", "name": "C0431693#ent", "pos": [20, 21]}}
{"token": ["The", "C0011849#ent", "<e1>", "was", "mostly", "of", "the", "C0431693#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0431693", "name": "C0431693#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "C0009325#ent", "<e1>", "degradation", "all", "the", "way", "to", "C0815040#ent", "<e2>", "postmortem", "in", "muscle", "and", "that", "there", "are", "active", "MMP", "simultaneously", "present", "that", "may", "account", "for", "this", "catabolism", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [11, 12]}}
{"token": ["Amino", "acid", "analysis", "that", "approximately", "30", "%", "of", "the", "amino", "acid", "residues", "of", "the", "C0009325#ent", "<e1>", "appeared", "in", "the", "lysosomal", "hydrolysate", "as", "C0815040#ent", "<e2>"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [22, 23]}}
{"token": ["Analysis", "of", "the", "C1436224#ent", "<e1>", "composition", "showed", "both", "cell", "lines", "high", "levels", "of", "the", "acidic", "C0017837#ent", "<e2>", "and", "lower", "concentrations", "of", "a", "basic", "isozyme", "."], "h": {"id": "C1436224", "name": "C1436224#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [15, 16]}}
{"token": ["This", "C1436224#ent", "<e1>", "cross-reacted", "with", "antibodies", "against", "anionic", "human", "placental", "C0017837#ent", "<e2>", "."], "h": {"id": "C1436224", "name": "C1436224#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [10, 11]}}
{"token": ["While", "patients", "with", "C2316810#ent", "<e1>", "treated", "by", "intermittent", "hemodialysis", "have", "frequent", "and", "progressive", "C0036310#ent", "<e2>", "nothing", "is", "known", "of", "the", "prevalence", "and", "course", "of", "valvular", "abnormalities", "patients", "treated", "with", "continuous", "ambulatory", "peritoneal", "dialysis", "CAPD", ")", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036310", "name": "C0036310#ent", "pos": [13, 14]}}
{"token": ["Various", "proteases", ",", "such", "as", "alpha-chymotrypsin", ",", "bromelain", ",", "C1257646#ent", "<e1>", ",", "trypsin", "and", "C0162745#ent", "<e2>", "were", "investigated", "for", "tissue", "stability"], "h": {"id": "C1257646", "name": "C1257646#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [14, 15]}}
{"token": ["These", "results", "support", "the", "hypothesis", "that", "corticosteroids", "have", "dual", "effects", "C0030807#ent", "<e1>", "through", "inhibition", "of", "C0032144#ent", "<e2>", "production", "by", "epidermal", "cells", "suppression", "of", "pemphigus", "antibody", "production", "by", "B", "lymphocytes"], "h": {"id": "C0030807", "name": "C0030807#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032144", "name": "C0032144#ent", "pos": [15, 16]}}
{"token": ["Clinical", "features", "of", "C0036323#ent", "<e1>", "range", "from", "fever", ",", "C0270697#ent", "<e2>", ",", "and", "lethargy", "to", "severe", "fibro-obstructive", "pathology", "leading", "to", "portal", "hypertension", "ascites", ",", "and", "hepatosplenomegaly", ",", "which", "can", "cause", "premature", "death"], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [9, 10]}}
{"token": ["This", "study", "demonstrates", "C1516876#ent", "<e1>", "based", "trade-offs", "between", "gonads", "and", "appendages", "in", "hatched", "larvae", "the", "C0885100#ent", "<e2>", "Prociphilus", "oriens", "focusing", "on", "enlarged", "variance", "among", "the", "families", "of", "selfed", "progeny", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0885100", "name": "C0885100#ent", "pos": [15, 16]}}
{"token": ["LMP", "showed", "significantly", "greater", "binding", "affinity", "for", "both", "C2699403#ent", "<e1>", "and", "serotonin-2", "binding", "sites", "than", "either", "CLOZ", "or", "C0008286#ent", "<e2>", ",", "and", "significantly", "greater", "binding", "to", "alpha-2", "sites", "than", "C0008286#ent", "<e2>", "."], "h": {"id": "C2699403", "name": "C2699403#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [18, 19]}}
{"token": ["We", "have", "identified", "the", "S(MK", ")", "box", "as", "a", "conserved", "RNA", "motif", "the", "5", "'", "untranslated", "leader", "region", "C1384557#ent", "<e1>", "(", "SAM", "synthetase", ")", "C1417679#ent", "<e2>", "in", "lactic", "acid", "bacteria", "including", "Enterococcus", ",", "Streptococcus", "and", "Lactococcus", "species"], "h": {"id": "C1384557", "name": "C1384557#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["After", "exercise", "both", "the", "released", "immunological", "C0032143#ent", "<e1>", "fibrinolytic", "capacity", "lower", "in", "the", "C0020480#ent", "<e2>", "patients", "than", "in", "the", "normolipidaemic", "patients", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020480", "name": "C0020480#ent", "pos": [13, 14]}}
{"token": ["C0526470#ent", "<e1>", "attenuated", "contractions", "to", "C3887648#ent", "<e2>", ",", "and", "all", "of", "the", "cannabinoids", "blocked", "contractions", "to", "KCl", "."], "h": {"id": "C0526470", "name": "C0526470#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [5, 6]}}
{"token": ["Elastic", "fiber", "formation", "and", "the", "C1415090#ent", "<e1>", "mRNA", "expression", "were", "examined", "by", "immunofluorescence", "with", "an", "anti-tropoelastin", "antibody", "and", "RT-PCR", "selective", "for", "C1415090#ent", "<e1>", "in", "skin", "fibroblasts", "these", "lysosomal", "enzyme", "C2713546#ent", "<e1>", "."], "h": {"id": "C1415090", "name": "C1415090#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [29, 30]}}
{"token": ["C0014118#ent", "<e1>", "for", "5", "-", "10", "%", "of", "all", "cases", "of", "C1541923#ent", "<e2>", "with", "the", "tricuspid", "valve", "frequently", "affected", "than", "the", "pulmonary", "valve"], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C1541923", "name": "C1541923#ent", "pos": [11, 12]}}
{"token": ["Only", "microsomes", "from", "B-lymphoblastoid", "cells", "expressing", "C1142644#ent", "<e1>", "were", "capable", "of", "catalysing", "the", "1'-", "and", "4-hydroxylation", "of", "C0002333#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0002333", "name": "C0002333#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "three", "drugs", "that", "inhibit", "adenosine", "elimination", ";", "two", "adenosine", "uptake", "C0001645#ent", "<e1>", ",", "dipyridamole", "and", "dilazep", ",", "the", "C2746041#ent", "<e2>", "EHNA", ",", "were", "also", "studied", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2746041", "name": "C2746041#ent", "pos": [21, 22]}}
{"token": ["Differences", "in", "metabolism", "of", "adenosine", "were", "determined", "in", "the", "absence", "and", "presence", "of", "dipyridamole", "(", "nucleoside", "uptake", "C0001645#ent", "<e1>", ")", "and", "erythro-9-(2-hydroxy-3-nonyl)adenine", "(", "EHNA", ",", "C2746041#ent", "<e2>", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2746041", "name": "C2746041#ent", "pos": [25, 26]}}
{"token": ["Pretreatment", "with", "the", "adenosine", "uptake", "C0001645#ent", "<e1>", "dipyridamole", "or", "the", "C2746041#ent", "<e2>", "deoxycoformycin", "enhanced", "the", "adenosine", "action", ",", "and", "this", "enhancement", "was", "not", "observed", "in", "the", "endothelium-denuded", "tissues", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2746041", "name": "C2746041#ent", "pos": [10, 11]}}
{"token": ["Several", "C0127082#ent", "<e1>", "MMPs", ")", "have", "been", "implicated", "in", "C0014335#ent", "<e2>", "mucosal", "wound", "healing", "and", "cancer", "progression"], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [9, 10]}}
{"token": ["C0005694#ent", "<e1>", "a", "well-known", "complication", "of", "C0042025#ent", "<e2>", "retropubic", "suspensions", "needle", "suspensions", ",", "and", "slings", "."], "h": {"id": "C0005694", "name": "C0005694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042025", "name": "C0042025#ent", "pos": [6, 7]}}
{"token": ["In", "1986", "we", "published", "a", "preliminary", "report", "describing", "a", "modification", "for", "C0005694#ent", "<e1>", "the", "treatment", "of", "C0042025#ent", "<e2>"], "h": {"id": "C0005694", "name": "C0005694#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042025", "name": "C0042025#ent", "pos": [16, 17]}}
{"token": ["It", "is", "a", "C0393814#ent", "<e1>", "the", "posterior", "tibial", "nerve", "it", "passes", "in", "the", "C0039319#ent", "<e2>", "the", "medial", "ankle", "flexor", "retinaculum", "."], "h": {"id": "C0393814", "name": "C0393814#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039319", "name": "C0039319#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "treatment", "of", "cells", "with", "a", "Rho", "inhibitor", "C0596543#ent", "<e1>", "or", "cellular", "overexpression", "dominant", "negative", "mutants", "of", "RhoA", "and", "C1419227#ent", "<e2>", "had", "no", "effect", "C.", "parvum", "invasion", "."], "h": {"id": "C0596543", "name": "C0596543#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419227", "name": "C1419227#ent", "pos": [21, 22]}}
{"token": ["We", "sought", "to", "determine", "the", "prevalence", "of", "C1535939#ent", "<e1>", "in", "children", "under", "12", "years", "of", "age", "who", "had", "C0000737#ent", "<e2>", "underwent", "abdominal", "radiography", "visiting", "an", "emergency", "department", "ED", ")", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [18, 19]}}
{"token": ["The", "149", "C3539947#ent", "<e1>", "from", "the", "C1416692#ent", "<e2>", "homology", "region", "required", "for", "colocalization", "of", "the", "two", "polypeptides", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416692", "name": "C1416692#ent", "pos": [6, 7]}}
{"token": ["With", "587", "C3539947#ent", "<e1>", ",", "they", "are", "among", "the", "smallest", "C1416692#ent", "<e2>", "known", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416692", "name": "C1416692#ent", "pos": [10, 11]}}
{"token": ["Fractional", "absorption", "calcium", "was", "determined", "in", "9", "children", "aged", "4.9", "to", "16.9", "yr", "with", "C0341439#ent", "<e1>", "determine", "the", "role", "of", "calcium", "malabsorption", "the", "development", "of", "C0025517#ent", "<e2>"], "h": {"id": "C0341439", "name": "C0341439#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [25, 26]}}
{"token": ["In", "more", "than", "80", "%", "of", "XLI", "patients", "the", "C0017923#ent", "<e1>", "due", "to", "large", "deletions", "involving", "the", "entire", "C0037556#ent", "<e2>", "gene", "and", "flanking", "sequences"], "h": {"id": "C0017923", "name": "C0017923#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0037556", "name": "C0037556#ent", "pos": [18, 19]}}
{"token": ["The", "exon-intron", "structure", "was", "highly", "homologous", "to", "human", "C1332772#ent", "<e1>", "and", "the", "deduced", "C2917660#ent", "<e2>", "of", "the", "N-", "and", "C-propeptides", "showed", "67", "%", "and", "91", "%", "identity", "with", "the", "human", "sequence", "."], "h": {"id": "C1332772", "name": "C1332772#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [13, 14]}}
{"token": ["with", "significant", "sequence", "identity", "to", "H.", "influenzae", "This", "gene", "encodes", "C1872855#ent", "<e1>", "is", "also", "involved", "in", "phase", "variation", "the", "C3273508#ent", "<e2>", "ChoP", "in", "H.", "influenzae"], "h": {"id": "C1872855", "name": "C1872855#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273508", "name": "C3273508#ent", "pos": [19, 20]}}
{"token": ["However", ",", "prevention", "is", "the", "best", "treatment", "of", "anuria", ":", "treatment", "of", "urinary", "tract", "infections", "in", "renal", "stones", "ultrasonographic", "monitoring", "for", "chronic", "proximal", "urinary", "tract", "dilatation", "tumors", ":", "C0424790#ent", "<e1>", "atraumatic", "operative", "technique", "avoiding", "C0013604#ent", "<e2>", "."], "h": {"id": "C0424790", "name": "C0424790#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [34, 35]}}
{"token": ["These", "results", "are", "consistent", "to", "observations", "that", "thymidine", "phosphorylase", "C0078956#ent", "<e1>", ")", "is", "predominantly", "expressed", "in", "monkeys", ";", "while", "uridine", "phosphorylase", "C1421363#ent", "<e2>", ")", "is", "superior", "to", "C0078956#ent", "<e1>", "in", "rats", "."], "h": {"id": "C1421363", "name": "C1421363#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [9, 10]}}
{"token": ["These", "results", "are", "consistent", "to", "observations", "that", "thymidine", "phosphorylase", "C0078956#ent", "<e1>", ")", "is", "predominantly", "expressed", "in", "monkeys", ";", "while", "C1421363#ent", "<e2>", "UPase", ")", "is", "superior", "to", "C0078956#ent", "<e1>", "in", "rats", "."], "h": {"id": "C1421363", "name": "C1421363#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [9, 10]}}
{"token": ["Histologically", ",", "IgA", "nephropathy", "C0027721#ent", "<e1>", "the", "main", "patterns", "among", "patients", "with", "C0017658#ent", "<e2>", "diffuse", "proliferative", "glomerulonephritis", "the", "commonest", "pattern", "among", "patients", "with", "lupus", "nephritis"], "h": {"id": "C0027721", "name": "C0027721#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [12, 13]}}
{"token": ["The", "results", "indicate", "that", "C0068770#ent", "<e1>", ",", "either", "alone", "or", "combined", "with", "C0033497#ent", "<e2>", "and", "penfluzide", ",", "is", "effective", "in", "the", "treatment", "of", "patients", "with", "essential", "hypertension"], "h": {"id": "C0068770", "name": "C0068770#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [12, 13]}}
{"token": ["To", "investigate", "the", "regulation", "of", "Kir6.2", "gene", "expression", ",", "we", "assessed", "C1416578#ent", "<e1>", "expression", "in", "IEC-6", "cells", "expressing", "Pdx-1", "and/or", "C1705599#ent", "<e2>", "."], "h": {"id": "C1416578", "name": "C1416578#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705599", "name": "C1705599#ent", "pos": [20, 21]}}
{"token": ["Binding", "of", "C0122812#ent", "<e1>", "to", "m-AR", "in", "LNCaP", "cells", "resulted", "in", "a", "concentration-dependent", "stimulation", "of", "PSA", "expression", ",", "suggesting", "that", "C0122812#ent", "<e1>", "acted", "as", "an", "C0243192#ent", "<e1>", "of", "the", "m-AR", "."], "h": {"id": "C0122812", "name": "C0122812#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [25, 26]}}
{"token": ["Types", "A", "and", "C0028064#ent", "<e1>", "NPD", ")", "are", "C0154251#ent", "<e2>", "by", "the", "deficient", "activity", "of", "acid", "sphingomyelinase", "ASM", ")", "."], "h": {"id": "C0028064", "name": "C0028064#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0154251", "name": "C0154251#ent", "pos": [8, 9]}}
{"token": ["The", "Type", "A", "B", "forms", "C0028064#ent", "<e1>", "NPD", ")", "are", "C0154251#ent", "<e2>", "to", "the", "deficient", "activity", "of", "the", "enzyme", "acid", "sphingomyelinase", "the", "resultant", "accumulation", "of", "sphingomyelin", "in", "cells", ",", "tissues", ",", "and", "fluids", "."], "h": {"id": "C0028064", "name": "C0028064#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0154251", "name": "C0154251#ent", "pos": [10, 11]}}
{"token": ["Also", "viral", "hepatitis", "obstructive", "jaundice", "autoimmune", "hepatitis", "primary", "biliary", "cirrhosis", "granulomatous", "hepatitis", "cryptococcus", "infection", "the", "liver", ",", "C0524909#ent", "<e1>", "IgA", "or", "IgD", "deficiency", "porphyria", "or", "idiopathic", "portal", "hypertension", "with", "C0014060#ent", "<e2>", "have", "been", "described", "."], "h": {"id": "C0524909", "name": "C0524909#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [29, 30]}}
{"token": ["Treatment", "with", "acyclovir", "and", "interferon-alpha", "rapidly", "improved", "her", "condition", ",", "stopped", "the", "lymphocyte", "outgrowth", "in", "culture", ",", "and", "reduced", "the", "C0149678#ent", "<e1>", "DNA", "content", "in", "oral", "secretions", "in", "C0221055#ent", "<e2>", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0221055", "name": "C0221055#ent", "pos": [28, 29]}}
{"token": ["Propranolol", "and", "aspirin", "represent", "two", "C0035064#ent", "<e1>", "commonly", "employed", "to", "treat", "C0007193#ent", "<e2>", "more", "than", "15", "years", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007193", "name": "C0007193#ent", "pos": [11, 12]}}
{"token": ["Despite", "the", "fact", "that", "early", "detection", "of", "C3813548#ent", "<e1>", "allows", "for", "successful", "and", "cost-effective", "treatment", "of", "the", "disease", ",", "only", "20", "%", "of", "C3813548#ent", "<e1>", "cases", "are", "diagnosed", "prior", "to", "a", "C0155668#ent", "<e1>"], "h": {"id": "C3813548", "name": "C3813548#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0155668", "name": "C0155668#ent", "pos": [31, 32]}}
{"token": ["The", "failure", "to", "diagnose", "this", "condition", "is", "generally", "a", "consequence", "of", "the", "attribution", "of", "the", "lower", "extremity", "weakness", "C0030554#ent", "<e1>", "to", "general", "debility", "concomitant", "C0031117#ent", "<e2>"], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [24, 25]}}
{"token": ["It", "probably", "plays", "a", "part", "in", "the", "clinical", ",", "and", "particularly", "the", "sensitive", "expression", "(", "C0030554#ent", "<e1>", "and", "pain", ")", "of", "some", "C0031117#ent", "<e2>", "certain", "central", "nervous", "system", "affections", ",", "such", "as", "multiple", "sclerosis"], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [22, 23]}}
{"token": ["Severe", "congestive", "heart", "failure", "severe", "C1704436#ent", "<e1>", "threatening", "gangrene", ",", "greater", "than", "first", "degree", "C0004245#ent", "<e2>", "hypotension", ",", "bradycardia", ",", "lung", "disease", "bronchospasm", ",", "and", "bronchial", "asthma", "contraindications", "to", "treatment", "with", "beta-blockers", "."], "h": {"id": "C1704436", "name": "C1704436#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004245", "name": "C0004245#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "analysis", "of", "neutrophils", "in", "these", "patients", "demonstrated", "that", "intracellular", "C0030306#ent", "<e1>", "content", "was", "largely", "reduced", "while", "C1413233#ent", "<e2>", "expression", "on", "plasma", "membrane", "substantially", "increased", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413233", "name": "C1413233#ent", "pos": [19, 20]}}
{"token": ["MKP-4", "also", "reversed", "the", "effect", "of", "C1710304#ent", "<e1>", "to", "inhibit", "insulin", "signaling", "alter", "IL-6", ",", "C1335837#ent", "<e2>", "and", "Glut4", "expression", ";", "and", "inhibit", "insulin-stimulated", "glucose", "uptake", "in", "3T3-L1", "adipocytes", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335837", "name": "C1335837#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "ANG", "II", "treatment", "of", "L6", "myotubes", "induced", "NF-kappaB", "activation", "C1710304#ent", "<e1>", "production", "and", "decreased", "insulin-stimulated", "Akt", "activation", "and", "C1335837#ent", "<e2>", "translocation", "to", "plasma", "membranes"], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335837", "name": "C1335837#ent", "pos": [20, 21]}}
{"token": ["Several", "genes", ",", "such", "as", "algD", ",", "oprF", "and", "C1332675#ent", "<e1>", "but", "not", "C0667830#ent", "<e2>", ",", "were", "required", "for", "tight", "microcolony", "formation"], "h": {"id": "C1332675", "name": "C1332675#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0667830", "name": "C0667830#ent", "pos": [13, 14]}}
{"token": ["At", "the", "nucleotide", "level", "homologues", "of", "Fas", "receptor", "C1332675#ent", "<e1>", ")", ",", "FADD", ",", "and", "C0667830#ent", "<e2>", "identified", "and", "characterized", "."], "h": {"id": "C1332675", "name": "C1332675#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0667830", "name": "C0667830#ent", "pos": [15, 16]}}
{"token": ["We", "have", "studied", "the", "effects", "of", "rate", "on", "the", "response", "of", "the", "murine", "radiation-induced", "fibrosarcoma", "C3890420#ent", "<e1>", ")", "to", "PDT", "using", "C0121300#ent", "<e2>", "(", "5", "mg/kg", ")", "."], "h": {"id": "C3890420", "name": "C3890420#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0121300", "name": "C0121300#ent", "pos": [21, 22]}}
{"token": ["C1455147#ent", "<e1>", "is", "an", "inhibitor", "of", "BCR-ABL", "and", "C0282625#ent", "<e2>", "patients", "with", "imatinib-resistant", "or", "-intolerant", "chronic", "myelogenous", "leukemia", "CML", ")", "."], "h": {"id": "C1455147", "name": "C1455147#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [8, 9]}}
{"token": ["Mutations", "in", "C1414964#ent", "<e1>", "were", "identified", "in", "giant", "axonal", "neuropathy", "C3810578#ent", "<e2>", ")", ",", "an", "autosomal", "recessive", "disorder"], "h": {"id": "C1414964", "name": "C1414964#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3810578", "name": "C3810578#ent", "pos": [10, 11]}}
{"token": ["Since", "macrophage", "oxidative", "burst", "(", "C3273409#ent", "<e1>", ")", "was", "found", "to", "increase", "in", "activated", "macrophages", "C0023786#ent", "<e2>", ")", ",", "we", "examined", "the", "C3273409#ent", "<e1>", "of", "peritoneal", "and", "spleen", "C0023786#ent", "<e2>", "from", "mice", "during", "GVHR", "."], "h": {"id": "C0023786", "name": "C0023786#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3273409", "name": "C3273409#ent", "pos": [5, 6]}}
{"token": ["These", "results", "are", "in", "accordance", "with", "the", "role", "of", "the", "motor", "cortex", "a", "generator", "of", "C0271829#ent", "<e1>", "and", "of", "RMC", "in", "the", "generalization", "of", "C0751495#ent", "<e2>", "."], "h": {"id": "C0271829", "name": "C0271829#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [24, 25]}}
{"token": ["A", "further", "finding", "was", "that", "C3641819#ent", "<e1>", ",", "but", "not", "full-length", "C1332410#ent", "<e2>", ",", "could", "stimulate", "the", "aggregation", "of", "SLUVs", "."], "h": {"id": "C3641819", "name": "C3641819#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332410", "name": "C1332410#ent", "pos": [11, 12]}}
{"token": ["C3641819#ent", "<e1>", ",", "the", "cleaved", "form", "of", "C1332410#ent", "<e2>", ",", "can", "induce", "cytochrome", "c", "Cyt", "."], "h": {"id": "C3641819", "name": "C3641819#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332410", "name": "C1332410#ent", "pos": [7, 8]}}
{"token": ["The", "role", "of", "NEP", "and", "ACE", "activities", "in", "the", "changes", "produced", "by", "dexamethasone", "was", "investigated", "by", "examining", "the", "effect", "of", "the", "C1517755#ent", "<e1>", "these", "enzymes", ",", "phosphoramidon", "and", "C0006938#ent", "<e2>", "."], "h": {"id": "C1517755", "name": "C1517755#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [28, 29]}}
{"token": ["Secondly", ",", "the", "capacity", "of", "human", "fetal", "C0051169#ent", "<e1>", "activate", "mutagens", "and", "C0085169#ent", "<e2>", "was", "confirmed", "using", "purified", "forms", "of", "C0051169#ent", "<e1>"], "h": {"id": "C0085169", "name": "C0085169#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [7, 8]}}
{"token": ["The", "possibility", "of", "retinoids", "in", "exerting", "their", "effects", "on", "mutagenesis", "of", "C0085169#ent", "<e1>", "by", "inhibiting", "only", "certain", "forms", "of", "C0051169#ent", "<e2>", "enzymes", "is", "discussed", "."], "h": {"id": "C0085169", "name": "C0085169#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [19, 20]}}
{"token": ["Twelve", "C0004096#ent", "<e1>", "children", "produced", "significantly", "better", "PEFR", "measurements", "when", "0.25", "mg", "C0039543#ent", "<e2>", "administered", "via", "an", "inhaler", "with", "the", "attachment", "than", "when", "an", "ordinary", "inhaler", "used", "alone", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0039543", "name": "C0039543#ent", "pos": [12, 13]}}
{"token": ["The", "absorption", "and", "excretion", "profiles", "orally", "administered", "terbutaline", "were", "investigated", "in", "10", "C0004096#ent", "<e1>", "patients", "who", "received", "a", "solution", "containing", "5", "mg", "of", "C0039543#ent", "<e2>"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0039543", "name": "C0039543#ent", "pos": [23, 24]}}
{"token": ["Seven", "C0004096#ent", "<e1>", "children", "(", "8", "-", "12", "years", ")", "were", "given", "C0039543#ent", "<e2>", "intravenously", "(", "5.5", "micrograms/kg", ")", "and", "orally", "(", "50", "micrograms/kg", ")", "one", "week", "apart", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0039543", "name": "C0039543#ent", "pos": [12, 13]}}
{"token": ["As", "a", "step", "towards", "the", "cloning", "of", "the", "gene", "for", "C1414525#ent", "<e1>", "C1414527#ent", "<e2>", ")", ",", "we", "have", "purified", "the", "C1414527#ent", "<e2>", "mRNA", "from", "rat", "liver", "by", "specific", "immunoadsorption", "of", "polysomes", "."], "h": {"id": "C1414525", "name": "C1414525#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414527", "name": "C1414527#ent", "pos": [12, 13]}}
{"token": ["It", "is", "caused", "by", "deficiency", "of", "C1414525#ent", "<e1>", "which", "prevents", "degradation", "of", "the", "toxic", "metabolite", "fumarylacetoacetate", "(", "C1414527#ent", "<e2>", ")", "."], "h": {"id": "C1414525", "name": "C1414525#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414527", "name": "C1414527#ent", "pos": [17, 18]}}
{"token": ["A", "double-blind", "study", "over", "12", "months", "was", "designed", "to", "assess", "the", "C0720099#ent", "<e1>", "of", "the", "antidyskinetic", "effect", "of", "amantadine", "on", "levodopa", "induced", "C0013384#ent", "<e2>", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [22, 23]}}
{"token": ["The", "influence", "of", "the", "C0720099#ent", "<e1>", "of", "levodopa", "treatment", "on", "the", "manifestation", "of", "C0013384#ent", "<e2>", "could", "not", "be", "confirmed", "because", "this", "side-effect", "usually", "appeared", "during", "the", "first", "year", "of", "treatment", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [13, 14]}}
{"token": ["The", "products", "of", "the", "MTS1/CDKN2", "and", "retinoblastoma", "(", "RB", ")", "tumor", "suppressor", "genes", "C0525037#ent", "<e1>", "and", "pRB", ",", "act", "as", "C0243192#ent", "<e2>", "in", "controlling", "the", "late", "G1", "cell", "cycle", "checkpoint"], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [20, 21]}}
{"token": ["Food", "allergy", "C0035455#ent", "<e1>", ",", "pharyngitis", "and", "C0023067#ent", "<e2>", "are", "discussed", "in", "relation", "to", "actual", "bibliography", "."], "h": {"id": "C0035455", "name": "C0035455#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023067", "name": "C0023067#ent", "pos": [7, 8]}}
{"token": ["Tumor", "cells", "treated", "with", "developed", "features", "compatible", "with", "C3537312#ent", "<e1>", ",", "with", "development", "of", "autophagic", "vacuoles", "conversion", "of", "an", "C1701777#ent", "<e2>", "microtubule-associated", "protein", "1", "light", "chain", "3", "type", "I", "cytoplasmic", "form", "to", "type", "II", "membrane", "form", "of", "autophagic", "vacuoles", "."], "h": {"id": "C3537312", "name": "C3537312#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1701777", "name": "C1701777#ent", "pos": [19, 20]}}
{"token": ["This", "affinity", "C0350056#ent", "<e1>", "did", "not", "bind", "C0016947#ent", "<e2>", "glucose", "dehydrogenase", "alcohol", "dehydrogenase", "or", "glucose", "oxidase"], "h": {"id": "C0350056", "name": "C0350056#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0016947", "name": "C0016947#ent", "pos": [7, 8]}}
{"token": ["C1414069#ent", "<e1>", "expressed", "mRNA", "that", "codes", "for", "the", "C0022173#ent", "<e2>"], "h": {"id": "C1414069", "name": "C1414069#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [8, 9]}}
{"token": ["Effects", "of", "C0947691#ent", "<e1>", "(", "pentylenetetrazole", "and", "C0015043#ent", "<e2>", "were", "studied", "in", "male", "albino", "rats", "aged", "7", ",", "12", ",", "18", "and", "90", "days", "."], "h": {"id": "C0947691", "name": "C0947691#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [7, 8]}}
{"token": ["We", "have", "previously", "shown", "that", "deletion", "of", "the", "SL1", "sequences", "compensated", "by", "C0017372#ent", "<e1>", "mutations", "within", "C0017346#ent", "<e2>", "."], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "we", "identified", "three", "C0017372#ent", "<e1>", "mutations", "within", "C0017346#ent", "<e2>", "named", "A238", "T", ",", "G358S", ",", "and", "N373", "K", "that", "rescued", "a", "deleterious", "mutation", "located", "at", "the", "C-terminus", "of", "CA"], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [11, 12]}}
{"token": ["C0082645#ent", "<e1>", "is", "a", "small", "C0018296#ent", "<e2>", ",", "which", "acts", "as", "a", "molecular", "switch", "regulate", "a", "wide", "variety", "of", "cellular", "functions", "such", "as", "actin", "cytoskeleton", "organization", ",", "cell", "proliferation", "apoptosis", ",", "cell", "migration", "in", "particular", ",", "cell", "polarity"], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [5, 6]}}
{"token": ["Collybistin", "belongs", "to", "the", "Dbl", "family", "of", "guanine", "nucleotide", "exchange", "factors", "occurs", "in", "multiple", "splice", "variants", "and", "is", "specific", "for", "C0082645#ent", "<e1>", ",", "a", "small", "C0018296#ent", "<e2>", "belonging", "to", "the", "Rho", "family"], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [20, 21]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [25, 26]}}
{"token": ["The", "genome", "sequence", "two", "distinct", "catalytic", "subunit", "genes", "C0010531#ent", "<e1>", ",", "named", "pkac-1", "(", "NCU06240.1", ",", "AAF75276", ")", "and", "C1418901#ent", "<e2>", "(", "NCU00682.1", ")", ",", "as", "is", "the", "case", "in", "most", "filamentous", "fungi"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418901", "name": "C1418901#ent", "pos": [19, 20]}}
{"token": ["C0010531#ent", "<e1>", "activating", "agents", "expression", "of", "the", "catalytic", "subunit", "C0010531#ent", "<e1>", "(", "C1418901#ent", "<e1>", ")", "inhibited", "the", "NF-kappaBeta-dependent", "reporter", "gene", "expression", "induced", "by", "tumor", "necrosis", "factor", "alpha", "TNFalpha", ")", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418901", "name": "C1418901#ent", "pos": [12, 13]}}
{"token": ["There", "is", "also", "evidence", "indicating", "that", "large", "serum", "proteins", "as", "C1412332#ent", "<e1>", ",", "large", "protein", "hormones", "as", "C1418938#ent", "<e2>", ",", "and", "small", "protein", "hormones", "such", "as", "insulin", "can", "enter", "intact", "cells", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [17, 18]}}
{"token": ["However", ",", "simultaneous", "immunostaining", "for", "both", "C0086376#ent", "<e1>", "revealed", "only", "two", "regions", "where", "C1871221#ent", "<e2>", "glutamic", "acid", "decarboxylase", "immunoreactivity", "were", "colocalized", ":", "the", "cerebellar", "Purkinje", "cells", "the", "commissural", "nucleus", "the", "stria", "terminalis"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1871221", "name": "C1871221#ent", "pos": [13, 14]}}
{"token": ["A", "21-month-old", "boy", "with", "the", "C0043194#ent", "<e1>", "conditioned", "with", "C1161438#ent", "<e2>", "and", "dimethyl", "myleran", "bone", "marrow", "an", "HLA-matched", "sibling", "."], "h": {"id": "C0043194", "name": "C0043194#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [9, 10]}}
{"token": ["The", "C0079405#ent", "<e1>", "first", "characterized", "as", "an", "C1415761#ent", "<e2>", "mouse", "precursor", "B", "pre-B", ")", "cells", "."], "h": {"id": "C0079405", "name": "C0079405#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415761", "name": "C1415761#ent", "pos": [7, 8]}}
{"token": ["Eleven", "male", "chronic", "schizophrenics", "were", "given", ",", "serially", ",", "C0031935#ent", "<e1>", "fluphenazine", ",", "and", "C0016367#ent", "<e2>", ";", "the", "two", "latter", "were", "also", "given", "intramuscularly", "as", "decanoates", "in", "oil", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016367", "name": "C0016367#ent", "pos": [14, 15]}}
{"token": ["The", "depolarizing", "postsynaptic", "potential", "was", "inhibited", "by", "C0031935#ent", "<e1>", ",", "chlorpromazine", ",", "haloperidol", ",", "C0016367#ent", "<e2>", ",", "curare", ",", "clozapine", ",", "(+)-butaclamol", "and", "high", "concentrations", "of", "ergometrine", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016367", "name": "C0016367#ent", "pos": [14, 15]}}
{"token": ["The", "renin-angiotensin", "system", "renal", "kinins", "C0356622#ent", "<e1>", "are", "all", "implicated", "in", "the", "regulation", "of", "glomerular", "filtration", "rate", "C1706512#ent", "<e2>", ")", ",", "renal", "blood", "flow", "RBF", ")", "and", "urinary", "sodium", "excretion", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706512", "name": "C1706512#ent", "pos": [17, 18]}}
{"token": ["To", "assess", "whether", "chronic", "treatment", "C1815010#ent", "<e1>", "can", "increase", "myocardial", "blood", "flow", "MBF", ")", "and", "MBF", "reserve", "in", "C2931157#ent", "<e2>", "IDC", ")", "."], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2931157", "name": "C2931157#ent", "pos": [18, 19]}}
{"token": ["We", "report", "the", "results", "obtained", "with", "long-term", "(", "3", "-", "4", "years", ")", "C1815010#ent", "<e1>", "administration", "to", "40", "patients", "with", "C2931157#ent", "<e2>", "were", "initially", "recruited", "in", "a", "4-month", "double-blind", "placebo-controlled", "trial"], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2931157", "name": "C2931157#ent", "pos": [20, 21]}}
{"token": ["When", "MLV", "are", "used", "to", "embed", "C1415468#ent", "<e1>", "in", "polypyrrole", "(", "C1418856#ent", "<e2>", ")", ",", "C1415468#ent", "<e1>", "behaves", "as", "a", "Michaelis-Menten", "enzyme", "."], "h": {"id": "C1415468", "name": "C1415468#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418856", "name": "C1418856#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "the", "availability", "of", "C0086376#ent", "<e1>", "such", "as", "receptor-interacting", "protein", "Fas-associated", "death", "domain", "and", "caspase-8", "can", "determine", "whether", "C1706001#ent", "<e2>", "activation", "will", "lead", "to", "apoptosis", "or", "to", "necrosis", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706001", "name": "C1706001#ent", "pos": [19, 20]}}
{"token": ["The", "thiol-specific", "probe", "maleimide-polyethylene", "glycol", "was", "used", "to", "selectively", "label", "the", "reduced", "thiol", "groups", "C0086376#ent", "<e1>", "of", "cell", "lysates", "fractions", "corresponding", "to", "C1706001#ent", "<e2>", "were", "then", "identified", "by", "immunoblot", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706001", "name": "C1706001#ent", "pos": [22, 23]}}
{"token": ["Paradoxically", ",", "SCCA1", "is", "an", "inhibitor", "of", "C0006784#ent", "<e1>", "such", "as", "C0054871#ent", "<e2>", "S", ",", "and", "K", ",", "whereas", "SCCA2", "inhibits", "chymotrypsin-like", "serine", "proteinases", "cathepsin", "G", "and", "mast", "cell", "chymase"], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [11, 12]}}
{"token": ["Domain", "2", "a", "good", "inhibitor", "of", "chicken", "calpain", "and", "also", "papain", "and", "cathepsin", "L.", "Domain", "3", "showed", "negligible", "inhibition", "of", "C0006784#ent", "<e1>", ",", "but", "inhibited", "papain", "and", "C0054871#ent", "<e2>", "."], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [27, 28]}}
{"token": ["Chromatin", "immunoprecipitation", "revealed", "that", "Mef2C", ",", "Tbx5", ",", "and", "C1421222#ent", "<e1>", "are", "direct", "target", "genes", "of", "C0906566#ent", "<e2>", "in", "vivo"], "h": {"id": "C1421222", "name": "C1421222#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0906566", "name": "C0906566#ent", "pos": [16, 17]}}
{"token": ["In", "limited", "trials", "C0031937#ent", "<e1>", "has", "also", "successfully", "reduced", "symptoms", "in", "patients", "with", "C0002962#ent", "<e2>", "anxiety", "and", "essential", "tremor"], "h": {"id": "C0031937", "name": "C0031937#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [13, 14]}}
{"token": ["The", "uterine", "peptidase", "substantially", "inhibited", "by", "EDTA", ",", "EGTA", ",", "1,10", "phenanthroline", ",", "C0039945#ent", "<e1>", ",", "DTT", ",", "and", "sodium", "dodecyl", "sulfate", "C0037506#ent", "<e2>", ")", "."], "h": {"id": "C0039945", "name": "C0039945#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [22, 23]}}
{"token": ["IFN-alpha", "proved", "to", "be", "ineffective", "in", "all", "eight", "C2697531#ent", "<e1>", ",", "whereas", "IFN-gamma", "induced", "marked", "growth", "inhibition", "four", "C2697531#ent", "<e1>", "that", "expressed", "wild-type", "C1705982#ent", "<e1>", "."], "h": {"id": "C2697531", "name": "C2697531#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705982", "name": "C1705982#ent", "pos": [23, 24]}}
{"token": ["Similarly", ",", "N-acetylcysteine", "and", "C0012789#ent", "<e1>", "did", "not", "alter", "the", "depressed", "responses", "C0017887#ent", "<e2>", "in", "arteries", "in", "which", "tolerance", "to", "C0017887#ent", "<e2>", "was", "induced", "in", "vitro"], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [12, 13]}}
{"token": ["Both", "mna2", "-", "1", "and", "mna2", "-", "2", ",", "the", "two", "available", "alleles", "of", "mna2", ",", "have", "conservative", "single", "C2917660#ent", "<e1>", "in", "the", "C3538704#ent", "<e2>"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "show", "that", "C1956003#ent", "<e1>", "interacts", "with", "C1528018#ent", "<e2>", "and", "dephosphorylates", "with", "surprising", "specificity", "at", "least", "two", "functional", "sites", "."], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1528018", "name": "C1528018#ent", "pos": [8, 9]}}
{"token": ["The", "presence", "of", "3.3", "mmol", "1(-1", ")", "CO2", "in", "the", "Ringer's", "solution", "a", "small", "effect", "relaxation", "after", "a", "brief", "C0039614#ent", "<e1>", ",", "but", "greatly", "slows", "relaxation", "as", "C0039614#ent", "<e1>", "C0720099#ent", "<e1>", "increases", "."], "h": {"id": "C0039614", "name": "C0039614#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [29, 30]}}
{"token": ["Renin-induced", "natriuretic", "action", "was", "prevented", "by", "C0013015#ent", "<e1>", "and", "by", "inhibition", "of", "tyrosine", "hydroxylase", "activity", "with", "C0051427#ent", "<e2>"], "h": {"id": "C0013015", "name": "C0013015#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051427", "name": "C0051427#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "overexpression", "of", "C1423053#ent", "<e1>", "did", "not", "inhibit", "nutrient-stimulated", "C2827382#ent", "<e2>", "activity", "."], "h": {"id": "C1423053", "name": "C1423053#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2827382", "name": "C2827382#ent", "pos": [11, 12]}}
{"token": ["Thirty", "infants", "with", "C0011991#ent", "<e1>", "dehydration", "were", "given", "C0282221#ent", "<e2>", "(", "0.8", "mg/kg/day", ")", ",", "in", "addition", "to", "standard", "fluid", "therapy", "for", "48", "hours", "after", "admission", "to", "the", "hospital", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0282221", "name": "C0282221#ent", "pos": [8, 9]}}
{"token": ["SSBP-1", "is", ",", "therefore", ",", "a", "positive", "regulator", "of", "C1336679#ent", "<e1>", "gene", "expression", "contributes", "to", "C1336679#ent", "<e1>", "maximal", "expression", "by", "binding", "to", "the", "C1423760#ent", "<e1>", "elements", "."], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1423760", "name": "C1423760#ent", "pos": [23, 24]}}
{"token": ["Complete", "healing", "(", "change", "to", "the", "S2", "stage", "after", "3", "or", "4", "weeks", "of", "treatment", "with", "C0050940#ent", "<e1>", "was", "observed", "in", "9.9", "%", "of", "C0038358#ent", "<e2>", "38.3", "%", "of", "duodenal", "ulcers"], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "the", "antitumour", "effects", "the", "conventional", "cytotoxic", "drug", "C1161438#ent", "<e1>", "and", "the", "tumour", "necrosis", "factor", "inducer", "C2930490#ent", "<e2>", "DMXAA", ")", "were", "found", "to", "be", "potentiated", "by", "thalidomide", "in", "mice", "bearing", "colon", "38", "adenocarcinoma", "tumours"], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2930490", "name": "C2930490#ent", "pos": [18, 19]}}
{"token": ["Two", "components", "of", "garlic", ",", "C0057693#ent", "<e1>", "DAS", ")", "and", "diallyl", "disulfide", "C0051767#ent", "<e2>", ")", ",", "inhibited", "arylamine", "N-acetyltransferase", "NAT", ")", "activity", "and", "2-aminofluorene-DNA", "adduct", "human", "promyelocytic", "leukemia", "cells", "HL-60", ")", "."], "h": {"id": "C0057693", "name": "C0057693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0051767", "name": "C0051767#ent", "pos": [12, 13]}}
{"token": ["Diallyl", "trisulfide", "DATS", ")", ",", "C0057693#ent", "<e1>", "DAS", ")", ",", "and", "diallyl", "disulfide", "C0051767#ent", "<e2>", ")", "are", "the", "three", "major", "organosulfur", "compounds", "OSCs", ")", "in", "garlic", "oil"], "h": {"id": "C0057693", "name": "C0057693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0051767", "name": "C0051767#ent", "pos": [13, 14]}}
{"token": ["Due", "to", "the", "low", "phosphoprotein", "phosphatase", "activity", "inhibition", "of", "the", "C1704708#ent", "<e1>", "activity", "by", "addition", "of", "okadaic", "acid", "little", "effect", "on", "the", "C1414295#ent", "<e2>", "phosphorylation", "kinetics", "."], "h": {"id": "C1704708", "name": "C1704708#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414295", "name": "C1414295#ent", "pos": [22, 23]}}
{"token": ["The", "activity", "of", "protein", "phosphatase", "2A", "C1704708#ent", "<e1>", ")", ",", "a", "phosphatase", "that", "dephosphorylates", "C1414295#ent", "<e2>", ",", "was", "also", "decreased", "in", "brain", "and", "liver", "from", "hibernators", "."], "h": {"id": "C1704708", "name": "C1704708#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414295", "name": "C1414295#ent", "pos": [14, 15]}}
{"token": ["Plasma", "concentrations", "of", "octanoate", "and", "cis-4-decenoate", "were", "measured", "by", "gas", "chromatography-mass", "spectrometry", "children", "with", "deficiencies", "of", "C1412107#ent", "<e1>", "MCAD", ")", ",", "long-chain", "3-hydroxyacyl-CoA", "dehydrogenase", "3LHAD", ")", "and", "C0268596#ent", "<e2>", "MAD", ")", "deficiency", "."], "h": {"id": "C1412107", "name": "C1412107#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268596", "name": "C0268596#ent", "pos": [27, 28]}}
{"token": ["These", "cells", "are", "deficient", "in", "the", "catalytic", "subunit", "C1528018#ent", "<e1>", "and", "in", "Ku", ",", "the", "C3537354#ent", "<e2>", "C1528018#ent", "<e1>", ",", "respectively", "."], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3537354", "name": "C3537354#ent", "pos": [15, 16]}}
{"token": ["It", "was", "found", "that", "C3887694#ent", "<e1>", "induced/enhanced", "transcription", "of", "MMP-1", "(", "interstitial", "collagenase", "and", "MMP-3", "(", "C0164371#ent", "<e2>", "in", "astrocytes", ",", "and", "MMP-1", ",", "MMP-9", "(", "gelatinase", "B", ",", "and", "TIMP-1", "in", "fibroblasts", "."], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [16, 17]}}
{"token": ["It", "was", "found", "that", "C3887694#ent", "<e1>", "induced/enhanced", "transcription", "of", "MMP-1", "(", "interstitial", "collagenase", "and", "C0164371#ent", "<e2>", "(", "stromelysin", "1", "in", "astrocytes", ",", "and", "MMP-1", ",", "MMP-9", "(", "gelatinase", "B", ",", "and", "TIMP-1", "in", "fibroblasts", "."], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [14, 15]}}
{"token": ["C0021246#ent", "<e1>", "did", "not", "protect", "C0007820#ent", "<e2>", "4", "h", "of", "STREP", "infusion", ",", "as", "%", "delta", "ICBF", "fell", "during", "hypercarbia", "by", "-10.9", "+", "/-", "17.7", "%", "(", "group", "2", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [5, 6]}}
{"token": ["While", "most", "of", "the", "C1412792#ent", "<e1>", "lacked", "such", "regions", "(", "and", "hence", "affinity", "for", "C0003438#ent", "<e2>", ")", "a", "minor", "proportion", "of", "the", "polysaccharide", "chains", "on", "the", "average", "three", "binding", "regions", "per", "molecule", "."], "h": {"id": "C1412792", "name": "C1412792#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [14, 15]}}
{"token": ["Clostridium", "perfringens", "type", "A", "isolates", "carrying", "an", "enterotoxin", "(", "cpe", ")", "C0079429#ent", "<e1>", "are", "an", "important", "cause", "of", "human", "C0017178#ent", "<e2>", "including", "food", "poisoning", "antibiotic-associated", "diarrhoea", "AAD", ")", "and", "sporadic", "diarrhoea", "SD", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [19, 20]}}
{"token": ["The", "best", "single", "indicator", "of", "a", "potent", "renal", "mechanism", "the", "C0020437#ent", "<e1>", "and", "also", "a", "poor", "response", "C0356588#ent", "<e2>", "was", "a", "low", "renal", "phosphate", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0356588", "name": "C0356588#ent", "pos": [17, 18]}}
{"token": ["Six", "treatment", "trials", "scabies", ",", "one", "study", "of", "the", "treatment", "of", "C0030756#ent", "<e1>", "and", "additional", "studies", "on", "the", "treatment", "of", "C0030757#ent", "<e2>", "included", "."], "h": {"id": "C0030756", "name": "C0030756#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030757", "name": "C0030757#ent", "pos": [20, 21]}}
{"token": ["HFf", "only", "partially", "converted", "Factor", "XI", "C1337109#ent", "<e1>", "and", "prekallikrein", "to", "C0752224#ent", "<e2>", "in", "plasma", "deficient", "HMW", "kininogen", "Williams", "trait", ",", "while", "enhanced", "activation", "of", "Factor", "XI", "prekallikrein", "by", "HFf", "resulted", "after", "reconstitution", "with", "HMW", "kininogen"], "h": {"id": "C1337109", "name": "C1337109#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752224", "name": "C0752224#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "prolonged", "moderate-intensity", "exercise", "human", "skeletal", "muscle", "AMP-activated", "protein", "kinase", "and", "-alpha2", "activity", "and", "C1412104#ent", "<e1>", "ACCbeta", ")", "and", "C0907533#ent", "<e2>", "nNOSmu", ")", "phosphorylation", "was", "investigated", "."], "h": {"id": "C1412104", "name": "C1412104#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [21, 22]}}
{"token": ["The", "C1335278#ent", "<e1>", "actions", "of", "C0106940#ent", "<e2>", "CE", ")", "on", "rabbit", "cultured", "chondrocytes", "were", "studied", "to", "assess", "the", "role", "of", "local", "acting", "growth", "factors", "the", "generation", "and", "expansion", "of", "highly", "differentiated", "cells", "."], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0106940", "name": "C0106940#ent", "pos": [5, 6]}}
{"token": ["Consequently", ",", "the", "excessive", "C0544482#ent", "<e1>", "to", "the", "erythrocyte", "membrane", "resulting", "in", "C1387532#ent", "<e2>"], "h": {"id": "C0544482", "name": "C0544482#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1387532", "name": "C1387532#ent", "pos": [12, 13]}}
{"token": ["C0015411#ent", "<e1>", "FGFR2", "syndromes", "are", "reported", "to", "include", "shallow", "orbits", "C0015300#ent", "<e2>", ",", "strabismus", ",", "and", "hypertelorism", ",", "but", "no", "ocular", "anterior", "chamber", "structural", "abnormalities", "been", "reported", "until", "now", "."], "h": {"id": "C0015411", "name": "C0015411#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015300", "name": "C0015300#ent", "pos": [10, 11]}}
{"token": ["The", "proposed", "method", "was", "applied", "to", "the", "simultaneous", "determination", "of", "C0017718#ent", "<e1>", ",", "1,5-AG", "and", "related", "C0001975#ent", "<e2>", "serum", "from", "healthy", "males", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [16, 17]}}
{"token": ["The", "activity", "of", "the", "two", "enzymes", "and", "the", "C0017718#ent", "<e1>", "uptake", "were", "therefore", "measured", "under", "the", "action", "of", "C0001975#ent", "<e2>", "related", "to", "the", "fluidity", "determined", "by", "ESR", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [18, 19]}}
{"token": ["Whereas", "increased", "Stat3", "phosphorylation", "occurs", "after", "C1416883#ent", "<e1>", "and", "cIAP2", "induction", ",", "the", "rapid", "upregulated", "phosphorylation", "of", "C3849574#ent", "<e2>", "and", "CREB", "may", "account", "for", "increased", "C1416883#ent", "<e1>", "and", "cIAP2", "by", "ATP", "."], "h": {"id": "C1416883", "name": "C1416883#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [17, 18]}}
{"token": ["This", "result", "suggests", "that", "topical", "OMZ", "may", "be", "clinically", "useful", "in", "the", "treatment", "of", "patients", "with", "C0040247#ent", "<e1>", "and", "probably", "those", "with", "other", "superficial", "C0026946#ent", "<e2>", "."], "h": {"id": "C0040247", "name": "C0040247#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [24, 25]}}
{"token": ["Its", "use", "in", "the", "treatment", "of", "C0040247#ent", "<e1>", "other", "superficial", "C0026946#ent", "<e2>", "reviewed", "here", "."], "h": {"id": "C0040247", "name": "C0040247#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [10, 11]}}
{"token": ["This", "case", "report", "different", "from", "Shwachman's", "syndrome", "but", "similar", "to", "a", "C0039082#ent", "<e1>", "of", "unknown", "etiology", ",", "recently", "described", "by", "C0342784#ent", "<e2>", "in", "4", "children", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0342784", "name": "C0342784#ent", "pos": [20, 21]}}
{"token": ["Surprisingly", ",", "when", "C1260386#ent", "<e1>", "is", "increased", "in", "the", "C0086661#ent", "<e2>", "low", "expressing", "cells", "by", "treatment", "with", "N-acetyl-L-cysteine", ",", "cells", "escape", "crisis", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [9, 10]}}
{"token": ["In", "N-FAECC", "and", "C2827389#ent", "<e1>", ",", "the", "large", "polygonal", "cells", "expressed", "gp100", ",", "C3274824#ent", "<e2>", "Melan-A", ",", "and", "reacted", "with", "monoclonal", "antibody", "."], "h": {"id": "C2827389", "name": "C2827389#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3274824", "name": "C3274824#ent", "pos": [13, 14]}}
{"token": ["C0018969#ent", "<e1>", "HO", ")", "is", "thought", "to", "be", "induced", "in", "severe", "C0024530#ent", "<e2>", ",", "but", "the", "pathophysiologic", "consequences", "have", "not", "been", "examined", "."], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}}
{"token": ["Patients", "taking", "C3539185#ent", "<e1>", "are", "at", "greater", "risk", "of", "Pneumocystis", "carinii", "C1535939#ent", "<e2>", "and", "may", "benefit", "from", "prophylactic", "therapy"], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "the", "identification", "of", "the", "C1738886#ent", "<e1>", "null", ",", "GSTM1", "A", "GSTM1", "B", "GSTM1", "A", "B", "polymorphisms", "the", "C0017837#ent", "<e2>", "using", "a", "single-step", "PCR", "method", "."], "h": {"id": "C1738886", "name": "C1738886#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [19, 20]}}
{"token": ["Simultaneously", ",", "we", "determined", "individual", "GSTT1", "and", "C1738886#ent", "<e1>", "genotypes", "and", "the", "activity", "of", "C0017837#ent", "<e2>", "GSTP", ")", ",", "catalase", "and", "superoxide", "dismutase", "SOD", ")", "in", "adult", "and", "foetal", "RBC", "."], "h": {"id": "C1738886", "name": "C1738886#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [14, 15]}}
{"token": ["More", "interestingly", ",", "C1332710#ent", "<e1>", "+", "CD44-", "cells", "expressing", "C1427306#ent", "<e2>", "CD10", "and", "CD19", "would", "represent", "unique", "B-lymphocyte", "committed", "precursors", "in", "the", "BM", ",", "which", "might", "undergo", "apoptotic", "cell", "death", "the", "early", "steps", "B-cell", "differentiation"], "h": {"id": "C1332710", "name": "C1332710#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1427306", "name": "C1427306#ent", "pos": [9, 10]}}
{"token": ["We", "also", "observed", "decreased", "fibroblast", "growth", "factor", "9", "C1333540#ent", "<e1>", ")", "expression", ",", "suggesting", "that", "effects", "of", "C1825463#ent", "<e2>", "in", "the", "myocardium", "are", "partly", "mediated", "through", "epicardial", "C1333540#ent", "<e1>", "signaling", "."], "h": {"id": "C1825463", "name": "C1825463#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333540", "name": "C1333540#ent", "pos": [8, 9]}}
{"token": ["The", "protective", "effect", "C1260386#ent", "<e1>", "was", "accompanied", "by", "an", "increased", "duodenal", "C1539718#ent", "<e2>", "expression", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539718", "name": "C1539718#ent", "pos": [11, 12]}}
{"token": ["This", "study", "reports", "the", "case", "of", "a", "76-yr-old", "male", "with", "C0042928#ent", "<e1>", "to", "lymph", "node", "involvement", "by", "C0037116#ent", "<e2>", "."], "h": {"id": "C0042928", "name": "C0042928#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037116", "name": "C0037116#ent", "pos": [17, 18]}}
{"token": ["The", "genes", "of", "the", "two", "C1538607#ent", "<e1>", "(", "named", "as", "C1418640#ent", "<e2>", "and", "PLC2", ")", "were", "adjoined", "and", "opposite", "in", "the", "direction", "of", "transcription/translation", "."], "h": {"id": "C1538607", "name": "C1538607#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418640", "name": "C1418640#ent", "pos": [10, 11]}}
{"token": ["The", "C0003195#ent", "<e1>", "be", "observed", "at", "a", "time", "when", "C0030196#ent", "<e2>", "and", "epicardial", "ECG", "waveforms", "are", "normal", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [9, 10]}}
{"token": ["To", "study", "the", "relationship", "between", "insulin", "sensitivity", "sodium-lithium", "countertransport", "Na(+)-Li+", "CT", ")", "in", "mild", ",", "C0085580#ent", "<e1>", "and", "to", "investigate", "the", "effect", "of", "metformin", "and", "C0025859#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [25, 26]}}
{"token": ["Thirty", "patients", "with", "C0085580#ent", "<e1>", "whose", "blood", "pressure", "controlled", "by", "C0025859#ent", "<e2>", ",", "were", "divided", "according", "to", "age", "in", "two", "groups", "."], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [10, 11]}}
{"token": ["C0063252#ent", "<e1>", "and", "sevoflurane", "were", "both", "superior", "to", "C0039925#ent", "<e2>", "."], "h": {"id": "C0063252", "name": "C0063252#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "constitutive", "v-rasH", "expression", "in", "DMS", "53", "SCLC", "cells", "and", "other", "neuroendocrine", "cell", "lines", "an", "important", "role", "for", "C0015230#ent", "<e1>", "or", "related", "C0017337#ent", "<e2>", "in", "neuroendocrine", "differentiation"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}}
{"token": ["They", "were", "located", "mainly", "in", "the", "structural", "genes", "C0015230#ent", "<e1>", "in", "the", "gag", "and", "C0017337#ent", "<e2>", "to", "a", "lesser", "extent", "in", "LTRs", "and", "regulatory", "genes"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["C0011777#ent", "<e1>", "also", "inhibited", "the", "induction", "of", "the", "C0132555#ent", "<e2>", "ex", "vivo", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [8, 9]}}
{"token": ["C0011777#ent", "<e1>", "completely", "inhibited", "the", "increase", "of", "C0132555#ent", "<e2>", "mRNA", "in", "response", "to", "Bt2", "cyclic", "AMP", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [7, 8]}}
{"token": ["We", "conclude", "that", "C0038395#ent", "<e1>", "infusion", "reduces", "ICBF", "and", "C0007820#ent", "<e2>", "acute", "hypercarbia", "piglets", "."], "h": {"id": "C0038395", "name": "C0038395#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [9, 10]}}
{"token": ["The", "main", "differential", "diagnoses", "of", "RA", "to", "be", "considered", "are", "the", "C0949691#ent", "<e1>", "psoriatic", "arthritis", "arthritides", "accompanying", "inflammatory", "bowel", "diseases", "C0035012#ent", "<e2>", "and", "spondylitis", "ankylosans", "with", "peripheral", "arthritis", ",", "Parvovirus-induced", "arthritis", ",", "crystal-induced", "arthritides", "septic", "arthritis"], "h": {"id": "C0949691", "name": "C0949691#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [20, 21]}}
{"token": ["An", "efficient", ",", "concise", "approach", "to", "the", "C3537143#ent", "<e1>", "core", "of", "the", "cryptophycins", ",", "potent", "C0003379#ent", "<e2>", "has", "been", "achieved", "."], "h": {"id": "C3537143", "name": "C3537143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003379", "name": "C0003379#ent", "pos": [15, 16]}}
{"token": ["This", "suggests", "that", "gastrin", "was", "directed", "to", "the", "regulated", "secretory", "pathway", "that", "some", "C0138435#ent", "<e1>", "products", "were", "C0669365#ent", "<e2>", "secreted", "."], "h": {"id": "C0138435", "name": "C0138435#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}}
{"token": ["Although", "C1825606#ent", "<e1>", "induced", "no", "C0041948#ent", "<e2>", ",", "ts14", ",", "ts22", "and", "ts26", "induced", "a", "lower", "titre", "but", "longer", "lasting", "C0041948#ent", "<e2>", "than", "the", "wild-type", "."], "h": {"id": "C1825606", "name": "C1825606#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [5, 6]}}
{"token": ["These", "results", "show", "essential", "roles", "for", "C0812303#ent", "<e1>", "and", "Ras", "in", "H(2)O(2)-mediated", "activation", "of", "C1419742#ent", "<e2>", "and", "establish", "redox-sensitive", "regulation", "of", "Ras", "and", "C1419742#ent", "<e2>", "as", "a", "new", "function", "for", "C0812303#ent", "<e1>", "."], "h": {"id": "C0812303", "name": "C0812303#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419742", "name": "C1419742#ent", "pos": [14, 15]}}
{"token": ["C0040553#ent", "<e1>", ",", "suggested", "by", "C3273421#ent", "<e2>", "and", "domestic", "contact", "with", "a", "puppy", ",", "was", "confirmed", "by", "anti-Toxocara", "IgG", "and", "IgE", "and", "Western", "blot"], "h": {"id": "C0040553", "name": "C0040553#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273421", "name": "C3273421#ent", "pos": [5, 6]}}
{"token": ["Situations", "with", "stimulated", "renin-angiotensin", "system", "RAS", ")", "like", "volume", "depletion", "or", "preexisting", "chronic", "renal", "failure", "to", "C3854173#ent", "<e1>", "ARF", ")", "via", "inhibition", "of", "prostaglandin", "synthesis", "C0080151#ent", "<e2>", "."], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [25, 26]}}
{"token": ["IL-2", "also", "increased", "arachidonic", "acid", "AA", ")", "production", "in", "CTLL-2", "cells", "probably", "via", "C0031667#ent", "<e1>", "PLA2", ")", "since", "the", "PLA2", "inhibitors", "phosphocholine", "and", "C0216938#ent", "<e2>", "(", "AACF", ")", "effectively", "blocked", "IL-2", "stimulated", "PKC", "activation", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0216938", "name": "C0216938#ent", "pos": [23, 24]}}
{"token": ["In", "vitro", "activity", "assay", "that", "TNF-alpha", "increased", "the", "dithiothreitol", "(DTT)-resistant", "C0031667#ent", "<e1>", "activity", "which", "was", "blocked", "by", "the", "cPLA2", "inhibitor", "C0216938#ent", "<e2>", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0216938", "name": "C0216938#ent", "pos": [20, 21]}}
{"token": ["The", "C1412179#ent", "<e1>", "ADA", ")", "was", "discriminate", "for", "80", "%", "of", "C0032231#ent", "<e2>", "."], "h": {"id": "C1412179", "name": "C1412179#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0032231", "name": "C0032231#ent", "pos": [11, 12]}}
{"token": ["The", "mean", "levels", "of", "activity", "of", "the", "key", "C0014442#ent", "<e1>", "of", "polyamine", "biosynthesis", "ornithine", "decarboxylase", "in", "epidermis", "damaged", "by", "C0033860#ent", "<e2>", "were", "6-fold", "higher", "than", "in", "normal", "epidermis"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [19, 20]}}
{"token": ["Both", "C0014442#ent", "<e1>", "were", "recently", "recognized", "as", "important", "in", "the", "pathophysiology", "of", "C0033860#ent", "<e2>", "because", "of", "their", "contribution", "to", "epidermal", "hyperproliferation"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [12, 13]}}
{"token": ["In", "spite", "of", "a", "reported", "association", "between", "sarcoidosis", "and", "C0033860#ent", "<e1>", ",", "serum", "angiotensin", "C0014442#ent", "<e2>", "activities", "have", "not", "been", "reported", "for", "patients", "with", "C0033860#ent", "<e1>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [9, 10]}}
{"token": ["Other", "clinical", "presentations", "C3815497#ent", "<e1>", ",", "stridor", "and", "C0003564#ent", "<e2>", "."], "h": {"id": "C3815497", "name": "C3815497#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003564", "name": "C0003564#ent", "pos": [8, 9]}}
{"token": ["The", "compounds", "were", "modified", "systematically", "at", "individual", "positions", "(", "P4", ",", "P3", ",", "P2", ",", "C1418887#ent", "<e1>", ",", "and", "P2t", "with", "the", "aim", "of", "mapping", "the", "C1332805#ent", "<e2>", "preferences", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332805", "name": "C1332805#ent", "pos": [26, 27]}}
{"token": ["We", "therefore", "wanted", "to", "assess", "whether", "C0051696#ent", "<e1>", ",", "a", "second", "generation", "C0012315#ent", "<e2>", "with", "a", "prolonged", "plasma", "half-life", ",", "would", "show", "a", "more", "favourable", "haemodynamic", "and", "biochemical", "profile", "strenuous", "exercise"], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [6, 7]}, "relation": "has_chemical_structure", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [12, 13]}}
{"token": ["A", "differential-pulse", "voltammetric", "method", "was", "developed", "for", "the", "determination", "of", "C0051696#ent", "<e1>", "based", "on", "the", "oxidation", "of", "the", "C0012315#ent", "<e2>", "the", "surface", "of", "glassy", "carbon", "electrode", "under", "stationary", "and", "rotating", "conditions", "."], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [10, 11]}, "relation": "has_chemical_structure", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [18, 19]}}
{"token": ["In", "submaxillary", "gland", "the", "activities", "of", "arginase", ",", "ornithine", "aminotransferase", "pyrroline-5-carboxylate", "reductase", "C1415119#ent", "<e1>", "high", ",", "but", "no", "ornithine", "transcarbamylase", "C1418945#ent", "<e2>", "be", "detected", "."], "h": {"id": "C1415119", "name": "C1415119#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418945", "name": "C1418945#ent", "pos": [20, 21]}}
{"token": ["Harmane", "and", "C0068994#ent", "<e1>", "are", "inhibitors", "of", "the", "C0026454#ent", "<e2>", "MAO-A", ")", "and", "B", "(", "MAO-B", ")", ",", "respectively", "."], "h": {"id": "C0068994", "name": "C0068994#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [8, 9]}}
{"token": ["C0004364#ent", "<e1>", "ABDs", ")", "are", "a", "rare", "but", "significant", "group", "of", "C0018567#ent", "<e2>", "that", "pose", "great", "challenges", "to", "the", "treating", "dermatologist", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018567", "name": "C0018567#ent", "pos": [11, 12]}}
{"token": ["Southern", "blot", "analysis", "C0011519#ent", "<e1>", "from", "human-mouse", "hybrid", "clones", "with", "an", "eph", "probe", "that", "this", "C0017337#ent", "<e2>", "was", "present", "on", "human", "chromosome", "7", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["The", "differentiation", "related", "changes", "in", "the", "C0011519#ent", "<e1>", "MNase", "digestion", "pattern", "in", "the", "5", "'", "region", "of", "the", "C0017337#ent", "<e2>", "suggest", "that", "sequences", "present", "in", "the", "first", "intron", "may", "be", "involved", "in", "gene", "regulation"], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["The", "sensitivity", "to", "C0011519#ent", "<e1>", "digestion", "of", "the", "C0017337#ent", "<e2>", "encoding", "rat", "phosphoenolpyruvate", "carboxykinase", "GTP", ")", "(", "EC", "4.1.1.32", ")", "was", "assessed", "during", "development", "and", "prior", "to", "the", "onset", "of", "expression", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["C0081947#ent", "<e1>", "is", "required", "for", "C1835361#ent", "<e2>", "duplication", "and", "Spc42", "assembly", ",", "and", "we", "found", "that", "C0081947#ent", "<e1>", "directly", "phosphorylates", "Spc42", "to", "promote", "its", "assembly", "into", "the", "C1835361#ent", "<e2>", "."], "h": {"id": "C0081947", "name": "C0081947#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1835361", "name": "C1835361#ent", "pos": [5, 6]}}
{"token": ["C0081947#ent", "<e1>", "was", "additionally", "found", "to", "be", "required", "for", "the", "C1835361#ent", "<e2>", "separation", "that", "precedes", "spindle", "formation", "preparation", "for", "the", "second", "meiotic", "division", "."], "h": {"id": "C0081947", "name": "C0081947#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1835361", "name": "C1835361#ent", "pos": [10, 11]}}
{"token": ["Long", "term", "up", "of", "adult", "patients", "with", "immune", "thrombocytopenic", "purpura", "ITP", ")", "have", "shown", "evolvement", "of", "C0004364#ent", "<e1>", "as", "SLE", ",", "C0272126#ent", "<e2>", "autoimmune", "neutropenia", "Graves", "disease", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0272126", "name": "C0272126#ent", "pos": [21, 22]}}
{"token": ["We", "performed", "a", "dose-escalation", "study", "for", "treatment", "of", "Japanese", "patients", "with", "C0004364#ent", "<e1>", "eight", "with", "SLE", "and", "one", "with", "C0272126#ent", "<e2>"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0272126", "name": "C0272126#ent", "pos": [19, 20]}}
{"token": ["Expression", "of", "C0907533#ent", "<e1>", "active-", "or", "inactive-forms", "of", "C1413355#ent", "<e2>", "also", "inhibits", "HEL", "cell", "and", "phosphorylated", "C1413355#ent", "<e2>", "is", "localized", "to", "the", "front", "protrusions", "of", "HEL", "cells"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413355", "name": "C1413355#ent", "pos": [8, 9]}}
{"token": ["Likewise", ",", "inactive", "S3E-cofilin", "and", "C0907533#ent", "<e1>", "active", "LIM", "kinase", "a", "direct", "upstream", "kinase", "of", "C1413355#ent", "<e2>", ",", "inhibited", "Y23E-AnxA2-induced", "scattering", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413355", "name": "C1413355#ent", "pos": [15, 16]}}
{"token": ["This", "review", "summarizes", "the", "large", "body", "of", "findings", "related", "to", "these", "renoprotective", "effects", "and", "reported", "during", "experimental", "and", "clinical", "research", "C0717550#ent", "<e1>", "for", "the", "treatment", "of", "C0011881#ent", "<e2>"], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [26, 27]}}
{"token": ["Preliminary", "results", "suggest", "that", "C0717550#ent", "<e1>", "can", "be", "useful", "in", "the", "treatment", "of", "C0011881#ent", "<e2>"], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", ",", "the", "clinical", "effects", "C0717550#ent", "<e1>", "were", "investigated", "and", "compared", "with", "ACE", "inhibitors", "patients", "with", "stage", "2", "C0011881#ent", "<e2>", "mainly", "with", "respect", "to", "the", "effects", "on", "the", "urinary", "excretion", "albumin", "and", "type", "IV", "collagen"], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [21, 22]}}
{"token": ["Because", "positive", "serologic", "findings", "for", "C0024198#ent", "<e1>", "been", "noted", "in", "patients", "with", "C0039483#ent", "<e2>", "have", "been", "exposed", "to", "areas", ",", "differential", "diagnosis", "be", "based", "on", "clinical", "manifestations"], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039483", "name": "C0039483#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "preliminary", "data", "suggest", "that", "some", "of", "these", "therapies", "may", "also", "slow", "progression", "in", "patients", "with", "C0403592#ent", "<e1>", "which", "has", "unfortunately", "become", "an", "increasingly", "common", "cause", "of", "C0035078#ent", "<e2>", "."], "h": {"id": "C0403592", "name": "C0403592#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [28, 29]}}
{"token": ["To", "study", "the", "photosensitization", "of", "dicoumarol", "(", "C0010927#ent", "<e1>", ")", "on", "tumor", "cells", "any", "effect", "by", "C0700086#ent", "<e2>", "DDC", ")", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0700086", "name": "C0700086#ent", "pos": [16, 17]}}
{"token": ["Proteolytic", "activity", "in", "preparations", "of", "C0001942#ent", "<e1>", "D.", "melanogaster", ",", "is", "considered", "due", "to", "a", "C0025543#ent", "<e2>", ",", "for", "which", "BrImPpOH", "is", "a", "potent", "inactivator", "."], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [15, 16]}}
{"token": ["The", "SDHA", ",", "SDHB", ",", "SDHC", "and", "C3273623#ent", "<e1>", "genes", "encode", "the", "subunits", "of", "C0038615#ent", "<e2>", "succinate", ":", "ubiquinone", "oxidoreductase", ",", "a", "component", "of", "both", "the", "Krebs", "cycle", "the", "mitochondrial", "respiratory", "chain"], "h": {"id": "C3273623", "name": "C3273623#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038615", "name": "C0038615#ent", "pos": [14, 15]}}
{"token": ["The", "combination", "of", "multiple", "cardiac", "abdominal", "wall", "myxomas", "pigmented", "C0037284#ent", "<e1>", "this", "young", "patient", "is", "considered", "to", "be", "a", "diagnostic", "feature", "C2607929#ent", "<e2>"], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2607929", "name": "C2607929#ent", "pos": [21, 22]}}
{"token": ["Data", "from", "the", "current", "investigation", "demonstrate", "the", "existence", "of", "C1334349#ent", "<e1>", "independent", "hexanal", "formation", "induced", "by", "reducing", "C0991617#ent", "<e2>", "in", "ISP", "and", "the", "potential", "requirement", "of", "iron", "as", "a", "catalyst", "."], "h": {"id": "C1334349", "name": "C1334349#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}}
{"token": ["It", "is", "likely", "that", "C0268532#ent", "<e1>", "a", "risk", "factor", "the", "development", "of", "C0024141#ent", "<e2>", "."], "h": {"id": "C0268532", "name": "C0268532#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [12, 13]}}
{"token": ["C0443469#ent", "<e1>", "PL", ")", "assists", "the", "absorption", "of", "dietary", "triglycerides", "C0054741#ent", "<e2>", "them", "at", "1", "and", "3", "positions", "to", "free", "fatty", "acids", "2-monoacylglycerol", "in", "the", "presence", "of", "bile", "acids", "colipase", "in", "the", "intestinal", "lumen"], "h": {"id": "C0443469", "name": "C0443469#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [10, 11]}}
{"token": ["Human", "C0443469#ent", "<e1>", "HPL", ",", "triacylglycerol", "acylhydrolase", "EC", "3.1.1.3", "is", "a", "C0054741#ent", "<e2>", "hydrolyzes", "insoluble", "emulsified", "triglycerides", "and", "is", "essential", "for", "the", "efficient", "digestion", "of", "dietary", "fats"], "h": {"id": "C0443469", "name": "C0443469#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [11, 12]}}
{"token": ["The", "method", "was", "used", "effectively", "in", "the", "first", "enzymatic", "preparation", "of", "both", "enantiomers", "of", "the", "title", "compound", "porcine", "C0443469#ent", "<e1>", "alcoholysis", "of", "its", "C0054741#ent", "<e2>"], "h": {"id": "C0443469", "name": "C0443469#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [23, 24]}}
{"token": ["Propyl", "gallate", "another", "alternative", "C0026457#ent", "<e1>", "also", "potentiated", "C0165603#ent", "<e2>", "activity", ",", "with", "a", "sum", "fractional", "inhibitory", "concentration", "of", "0.7", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0165603", "name": "C0165603#ent", "pos": [8, 9]}}
{"token": ["The", "PLC", "contains", "a", "C1427907#ent", "<e1>", "transporter", "associated", "with", "antigen", "processing", ",", "a", "thiooxido-reductase", "(", "C0251914#ent", "<e2>", ")", ",", "a", "glycoprotein", "chaperone", "calreticulin", ")", ",", "and", "tapasin", ",", "a", "class", "I-specific", "chaperone", "."], "h": {"id": "C1427907", "name": "C1427907#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0251914", "name": "C0251914#ent", "pos": [15, 16]}}
{"token": ["C0058836#ent", "<e1>", "also", "detected", "by", "C3272771#ent", "<e2>", "probing", ",", "and", "the", "method", "accurately", "reports", "a", "previously", "characterized", "pH-dependent", "conformational", "transition", "formation", "of", "a", "protonated", "C-A", "pair", "and", "base", "flipping", "."], "h": {"id": "C0058836", "name": "C0058836#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272771", "name": "C3272771#ent", "pos": [5, 6]}}
{"token": ["The", "aim", "of", "the", "study", "was", "the", "analysis", "of", "C0024198#ent", "<e1>", "cases", "notified", "by", "Clinic", "for", "C0009450#ent", "<e2>", "Wroc\u0142aw", "in", "connection", "with", "exposure", "to", "ticks", "in", "year", "2002", "."], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [16, 17]}}
{"token": ["We", "identified", "83", "persons", "with", "C0024198#ent", "<e1>", "27", "with", "HGE", ",", "and", "11", "with", "apparent", "C0009450#ent", "<e2>", "."], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [15, 16]}}
{"token": ["Vaccines", "against", "pertussis", ",", "C0024198#ent", "<e1>", "cholera", ",", "herpes", "simplex", "malaria", ",", "other", "C0009450#ent", "<e2>", "and", "cancer", "are", "in", "various", "stages", "of", "development", "."], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [13, 14]}}
{"token": ["We", "discuss", "this", "novel", "phenomenon", "in", "terms", "of", "its", "possible", "underlying", "mechanisms", "and", "its", "relevance", ",", "both", "in", "the", "context", "of", "the", "immunology", "of", "C0024198#ent", "<e1>", "that", "of", "other", "C0009450#ent", "<e2>"], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [24, 25]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [29, 30]}}
{"token": ["In", "this", "study", "we", "examine", "whether", "the", "improved", "cardiac", "function", "beta", "blockade", "therapy", "C0018801#ent", "<e1>", "associated", "with", "alteration", "in", "C0342790#ent", "<e2>", "activity", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0342790", "name": "C0342790#ent", "pos": [19, 20]}}
{"token": ["C1099413#ent", "<e1>", "CTL", ")", "proteins", "of", "the", "C1822758#ent", "<e2>", "family", "are", "novel", "transmembrane", "proteins", "in", "choline", "transport", "phospholipid", "synthesis"], "h": {"id": "C1099413", "name": "C1099413#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1822758", "name": "C1822758#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", ",", "a", "mouse", "gene", "cDNA", "encoding", "for", "a", "novel", "skeletal", "C1099413#ent", "<e1>", "C1822758#ent", "<e2>", ")", "were", "identified", "and", "C1822758#ent", "<e2>", "mRNA", "and", "protein", "expression", "."], "h": {"id": "C1099413", "name": "C1099413#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1822758", "name": "C1822758#ent", "pos": [15, 16]}}
{"token": ["The", "authors", "report", "a", "case", "of", "C0265514#ent", "<e1>", "a", "66-year", "old", "woman", "who", "had", "been", "admitted", "for", "C0521516#ent", "<e2>", "rheumatica", "."], "h": {"id": "C0265514", "name": "C0265514#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0521516", "name": "C0521516#ent", "pos": [17, 18]}}
{"token": ["We", "show", "here", "that", "B", "cell", "proliferation", "polyclonal", "antibody", "production", "in", "response", "to", "Gram-negative", "bacterial", "infection", "modulated", "by", "C1412429#ent", "<e1>", "a", "host", "C0027203#ent", "<e2>", "that", "deacylates", "bacterial", "lipopolysaccharides"], "h": {"id": "C1412429", "name": "C1412429#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [22, 23]}}
{"token": ["C1412429#ent", "<e1>", "AOAH", ")", "is", "an", "C0027203#ent", "<e2>", ",", "found", "in", "phagocytic", "cells", "that", "catalyzes", "the", "enzymatic", "deacylation", "the", "lipid", "A", "moiety", "of", "LPS", "."], "h": {"id": "C1412429", "name": "C1412429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}}
{"token": ["The", "major", "human", "C1424869#ent", "<e1>", "C3889430#ent", "<e2>", "PRP", "II", "PRP", "III", "and", "PRP", "IV", "well", "as", "several", "minor", "C1424869#ent", "<e1>", "cross-react", "with", "antiserum", "to", "C3889430#ent", "<e2>", "PRP", "III", "."], "h": {"id": "C3889430", "name": "C3889430#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424869", "name": "C1424869#ent", "pos": [3, 4]}}
{"token": ["We", "conclude", "that", "in", "smooth", "muscle", "sstr3", "is", "coupled", "to", "C1427865#ent", "<e1>", "and", "Go", ";", "the", "alpha", "subunits", "both", "G", "proteins", "inhibition", "of", "C1382029#ent", "<e2>", "while", "the", "betagamma", "subunits", "mediate", "activation", "of", "PLC-beta3", "."], "h": {"id": "C1427865", "name": "C1427865#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "the", "primary", "function", "C2987155#ent", "<e1>", "binding", "is", "to", "enable", "cell", "surface", "C0287990#ent", "<e2>", "cleavage", "of", "L2", "and", "that", "binding", "to", "a", "distinct", "cell", "surface", ")", "is", "a", "subsequent", "step", "of", "papillomavirus", "infection"], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0287990", "name": "C0287990#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "on", "peak", "3", "of", "either", "unilateral", "C0085196#ent", "<e1>", "lesion", "of", "the", "substantia", "nigra", "intraperitoneal", "administration", "C0051427#ent", "<e2>", ",", "supports", "our", "earlier", "conclusion", "that", "peak", "3", "due", "to", "the", "dopamine", "metabolite", "homovanillic", "acid"], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0051427", "name": "C0051427#ent", "pos": [17, 18]}}
{"token": ["There", "were", "72", "cases", "of", "hemoglobinopathy", ":", "65", "thalassemia", "trait", "four", "C2242796#ent", "<e1>", ",", "and", "one", "each", "of", "Hb", "D-thalassemia", ",", "C0002895#ent", "<e2>", "and", "sickle-cell", "anemia"], "h": {"id": "C2242796", "name": "C2242796#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [21, 22]}}
{"token": ["This", "constitutes", "an", "encouraging", "result", "for", "obtaining", "novel", "C0597128#ent", "<e1>", "this", "class", "of", "C3494348#ent", "<e2>"], "h": {"id": "C0597128", "name": "C0597128#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [13, 14]}}
{"token": ["We", "decreased", "arterial", "PO2", "three", "different", "rates", "and", "measured", "blood", "pressure", "BP", ")", ",", "vasopressin", "(", "C1366535#ent", "<e1>", ")", ",", "ACTH", ",", "and", "C3536709#ent", "<e2>", "levels", "in", "nonsurgically", "stressed", ",", "anesthetized", ",", "paralyzed", "dogs", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [23, 24]}}
{"token": ["It", "has", "recently", "been", "shown", "that", "C1366535#ent", "<e1>", "from", "SCN", "inhibits", "C3536709#ent", "<e2>", "release", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [11, 12]}}
{"token": ["The", "presence", "of", "C1366535#ent", "<e1>", "the", "adrenal", "gland", "nonmammalian", "vertebrates", "the", "possible", "action", "of", "these", "regulatory", "peptides", "C3536709#ent", "<e2>", "secretion", "have", "never", "been", "investigated", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [17, 18]}}
{"token": ["Motifs", "in", "the", "intracellular", "domain", "of", "C1424154#ent", "<e1>", "known", "to", "interact", "with", "PTB", "and", "SH2", "domains", "necessary", "for", "C1424154#ent", "<e1>", "but", "not", "for", "clustering", "."], "h": {"id": "C1424154", "name": "C1424154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1424154", "name": "C1424154#ent", "pos": [6, 7]}}
{"token": ["These", "studies", "suggest", "a", "physical", "link", "C1424154#ent", "<e1>", "or", "CD91/LRP", "and", "the", "adapter", "protein", "during", "C1424154#ent", "<e1>", "of", "apoptotic", "cells", "further", "elucidate", "the", "pathway", "suggested", "by", "the", "genetic", "studies"], "h": {"id": "C1424154", "name": "C1424154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1424154", "name": "C1424154#ent", "pos": [6, 7]}}
{"token": ["C0302362#ent", "<e1>", "a", "facultative", ",", "intracellular", ",", "gram-negative", "cocco-bacillus", "that", "causes", "C0015967#ent", "<e2>", "humans", "and", "brucellosis", "in", "animals", "."], "h": {"id": "C0302362", "name": "C0302362#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [11, 12]}}
{"token": ["The", "significance", "of", "four", "amino", "acid", "in", "the", "nonstructural", "proteins", "NS4b", "and", "C1706586#ent", "<e1>", ",", "a", "presumed", "transport", "protein", "the", "C0035681#ent", "<e2>", "respectively", ",", "remains", "unknown", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [20, 21]}}
{"token": ["C0684275#ent", "<e1>", "is", "a", "C0018939#ent", "<e2>", "by", "undetectable", "or", "low", "amounts", "of", "functional", "coagulation", "factor", "VIII", "FVIII", ")", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [4, 5]}}
{"token": ["BACKGROUND", ":", "C0684275#ent", "<e1>", "is", "a", "C0018939#ent", "<e2>", "by", "impaired", "coagulability", "of", "the", "blood", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [6, 7]}}
{"token": ["C0684275#ent", "<e1>", "is", "a", "rare", ",", "C0018939#ent", "<e2>", "which", "blood", "clotting", "impaired", "such", "that", "patients", "suffer", "from", "excessive", "internal", "and", "external", "bleeding", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [6, 7]}}
{"token": ["Addition", "of", "C0077274#ent", "<e1>", "did", "not", "suppress", "activation", "of", "C1456380#ent", "<e2>", "JNK", ",", "or", "PI3K", "response", "to", "IL-1beta", "."], "h": {"id": "C0077274", "name": "C0077274#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [9, 10]}}
{"token": ["Induction", "of", "hydrolase", "I", "C0020289#ent", "<e1>", "peroxisomal", "beta-oxidation", "hepatomegaly", "caused", "by", "C0009003#ent", "<e2>", "rho-chlorophenoxyisobutyric", "acid", "administration", "was", "investigated", "in", "relation", "to", "alterations", "in", "hormonal", "state", "glucocorticoid", ",", "thyroid", "hormone", "insulin", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009003", "name": "C0009003#ent", "pos": [11, 12]}}
{"token": ["In", "hepatic", "cytosol", "guinea-pig", ",", "C0020289#ent", "<e1>", "induced", "by", "the", "administration", "of", "C0009003#ent", "<e2>"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009003", "name": "C0009003#ent", "pos": [12, 13]}}
{"token": ["We", "have", "investigated", "the", "effect", "of", "C0018034#ent", "<e1>", "auranofin", ",", "gold", "compounds", "in", "the", "treatment", "of", "C0003873#ent", "<e2>", "on", "production", "of", "macrophage-derived", "angiogenic", "activity"], "h": {"id": "C0018034", "name": "C0018034#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["To", "compare", "the", "safety", "and", "efficacy", "of", "methotrexate", "(", "MTX", ")", "and", "C0018034#ent", "<e1>", "GSTM", ")", "in", "patients", "with", "active", "early", "erosive", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "during", "3", "yr", "."], "h": {"id": "C0018034", "name": "C0018034#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [24, 25]}}
{"token": ["Pulse", "prednisolone", "hemisuccinate", "therapy", "500", "mg", "given", "intravenously", "on", "three", "occasions", "over", "two", "weeks", ")", "has", "been", "combined", "with", "either", "intramuscular", "C0018034#ent", "<e1>", "azathioprine", "in", "an", "assessment", "of", "30", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0018034", "name": "C0018034#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [31, 32]}}
{"token": ["A", "second", "TSP1", "receptor", ",", "CD47", ",", "was", "not", "required", "for", "some", "stimulatory", "responses", "to", "C1336626#ent", "<e1>", "but", "played", "a", "significant", "role", "in", "its", "T", "cell", "antigen", "receptor", "antagonist", "C0003392#ent", "<e2>"], "h": {"id": "C1336626", "name": "C1336626#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [29, 30]}}
{"token": ["C0012091#ent", "<e1>", "is", "a", "non-steroidal", "anti-inflammatory", "agent", "for", "use", "in", "C0003873#ent", "<e2>", "degenerative", "joint", "disease", "ankylosing", "spondylitis"], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}}
{"token": ["Biochemical", "evaluation", "a", "C0020455#ent", "<e1>", "hypoalbuminaemia", "and", "C0149911#ent", "<e2>", "."], "h": {"id": "C0020455", "name": "C0020455#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149911", "name": "C0149911#ent", "pos": [7, 8]}}
{"token": ["These", "are", ":", "C0271889#ent", "<e1>", "asthenic", "neurosis", "sympathetic", "truncitis", ",", "epilepsy", ",", "and", "C0241832#ent", "<e2>", "the", "vertebrobasilar", "basin"], "h": {"id": "C0271889", "name": "C0271889#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0241832", "name": "C0241832#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "we", "have", "confirmed", "one", "of", "the", "newly", "found", "interactions", "between", "C0812265#ent", "<e1>", "and", "the", "membrane-associated", "RGS4", "protein", "coimmunoprecipitating", "the", "two", "C0086376#ent", "<e2>", "from", "human", "cells"], "h": {"id": "C0812265", "name": "C0812265#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [23, 24]}}
{"token": ["RGS4", "interacts", "with", "C0812265#ent", "<e1>", "that", "acts", "as", "receptors", "for", "neuregulin", "1", "these", "C0086376#ent", "<e2>", "may", "play", "a", "role", "in", "the", "pathogenesis", "of", "schizophrenia", "via", "glutamatergic", "dysfunction"], "h": {"id": "C0812265", "name": "C0812265#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["rhBMP-2", "retention", "in", "C0252916#ent", "<e1>", "scaffolds", "was", "greater", "than", "that", "from", "C1333079#ent", "<e2>", "which", "released", "most", "of", "the", "initially", "loaded", "rhBMP-2", "by", "14", "days", "."], "h": {"id": "C0252916", "name": "C0252916#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333079", "name": "C1333079#ent", "pos": [11, 12]}}
{"token": ["The", "fixed", "combination", "of", "brimonidine", "tartrate", "%", "and", "C0040233#ent", "<e1>", "maleate", "0.5", "%", "(", "FCBT", ")", "combines", "a", "highly", "selective", "C2746076#ent", "<e2>", "brimonidine", ")", "with", "a", "non-selective", "beta-blocker", "C0040233#ent", "<e1>", ")", "."], "h": {"id": "C2746076", "name": "C2746076#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0040233", "name": "C0040233#ent", "pos": [8, 9]}}
{"token": ["Inhibitors", "of", "C0534519#ent", "<e1>", "or", "cathepsins", "failed", "to", "protect", "against", "C1427198#ent", "<e2>", "cytotoxicity", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1427198", "name": "C1427198#ent", "pos": [10, 11]}}
{"token": ["The", "C1413231#ent", "<e1>", "was", "to", "determine", "the", "role", "CGRP", "and/or", "C1420563#ent", "<e2>", "released", "from", "sensory", "neural", "mechanisms", "in", "enteric", "neural", "vasodilator", "pathways"], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420563", "name": "C1420563#ent", "pos": [10, 11]}}
{"token": ["The", "present", "study", "investigated", "whether", "the", "following", "peroxisome", "proliferators", "affect", "Leydig", "cell", "function", "in", "vitro", "2,4-dichlorophenoxyacetic", "acid", "ammonium", "perfluorooctanoate", "C0004057#ent", "<e1>", "clofibric", "acid", "ciprofibrate", ",", "gemfibrozil", ",", "tiadenol", ",", "tibric", "acid", "trichloroacetic", "acid", "C0040905#ent", "<e2>", ",", "and", "Wyeth", "14,643"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0040905", "name": "C0040905#ent", "pos": [33, 34]}}
{"token": ["In", "control", "arteries", "0.1", "muM", "phentolamine", "and", "0.1", "muM", "C0032912#ent", "<e1>", "suppressed", "responses", "to", "1", "muM", "C0014704#ent", "<e2>", "by", "71", "and", "90", "%", ",", "respectively", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014704", "name": "C0014704#ent", "pos": [16, 17]}}
{"token": ["The", "simultaneous", "treatment", "of", "the", "E2-implanted", "rats", "with", "P4", "and/or", "C0011777#ent", "<e1>", "reduced", "the", "C0567085#ent", "<e2>", "PGF", "concentrations", "considerably", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [14, 15]}}
{"token": ["Immunoblot", "analysis", "that", "C0078956#ent", "<e1>", "induced", "prolonged", "hyperphosphorylation", "of", "C1706586#ent", "<e2>", "and", "activation", "of", "extracellular-regulated/mitogen-activated", "protein", "kinases", "1", "and", "2", "in", "untransfected", "LNCaP", "cells", ",", "as", "did", "bryostatin", "1", "in", "PKCalpha-overexpressing", "cells", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [9, 10]}}
{"token": ["The", "results", "also", "demonstrate", "that", "retinoic", "acid-treated", "HL-525", "cells", "respond", "to", "C0078956#ent", "<e1>", "with", "activation", "of", "C1706586#ent", "<e2>", "and", "MAP", "kinase", "as", "well", "as", "induction", "of", "monocytic", "differentiation", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [16, 17]}}
{"token": ["C0017905#ent", "<e1>", "extracted", "with", "water", "and", "C0014994#ent", "<e2>", "and", "was", "determined", "in", "the", "aqueous", "residue", "by", "high-pressure", "liquid", "column", "chromatography"], "h": {"id": "C0017905", "name": "C0017905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014994", "name": "C0014994#ent", "pos": [6, 7]}}
{"token": ["Interestingly", ",", "the", "residue", "with", "its", "surrounding", "eight", "C3539946#ent", "<e1>", "aligned", "between", "mouse", "b-protein", "and", "human", "C0012524#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012524", "name": "C0012524#ent", "pos": [16, 17]}}
{"token": ["C1414369#ent", "<e1>", "induced", "the", "expression", "of", "COX-2", "mRNA", ",", "protein", "and", "activity", "in", "the", "C1571454#ent", "<e2>", "stimulated", "with", "C1414369#ent", "<e1>", "."], "h": {"id": "C1571454", "name": "C1571454#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414369", "name": "C1414369#ent", "pos": [0, 1]}}
{"token": ["A", "B(2)R", "exon", "2", "polymorphism", "(", "C(181", ")", "--", ">", "T", ")", "selectively", "influenced", "the", "potency", "of", "C1537501#ent", "<e1>", "(", "EC(50", ")", "higher", "when", "the", "C0002085#ent", "<e2>", "present", ")", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [25, 26]}}
{"token": ["The", "effects", "of", "minoxidil", "and", "the", "angiotensin-converting", "enzyme", "inhibitor", "SQ", "14,225", "blood", "pressure", "sodium", "balance", "plasma", "renin", "activity", "plasma", "aldosterone", "concentration", ",", "aldosterone", "excretion", "rate", ",", "and", "renal", "function", "studied", "in", "11", "C0206526#ent", "<e1>", "hypertensive", "patients", "under", "controlled", "diets", "C3714642#ent", "<e2>", "and", "potassium", "intake"], "h": {"id": "C0206526", "name": "C0206526#ent", "pos": [32, 33]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [39, 40]}}
{"token": ["While", "calmodulin", "has", "many", "known", "effectors", ",", "including", "kinases", ",", "C0757672#ent", "<e1>", ",", "motor", "proteins", "channels", "and", "C0001492#ent", "<e2>", "no", "structures", "calmodulin", "in", "complex", "with", "a", "functional", "enzyme", "have", "been", "solved", "."], "h": {"id": "C0757672", "name": "C0757672#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [17, 18]}}
{"token": ["In", "arrested", "preparations", ",", "beta-adrenoceptor", "activation", "a", "hyperpolarization", ",", "as", "did", "the", "inhibition", "of", "C0757672#ent", "<e1>", "or", "the", "activation", "of", "C0001492#ent", "<e2>"], "h": {"id": "C0757672", "name": "C0757672#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [20, 21]}}
{"token": ["TLR", "signaling", "enhances", "the", "interaction", "of", "MyD88", "and", "C1823491#ent", "<e1>", "with", "Beclin", "1", "and", "reduces", "the", "binding", "of", "Beclin", "1", "C0376515#ent", "<e2>", "."], "h": {"id": "C1823491", "name": "C1823491#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [20, 21]}}
{"token": ["It", "also", "significantly", "delayed", "the", "onset", "of", "C0242723#ent", "<e1>", "(", "i.e.", ",", "lengthened", "the", "C0043440#ent", "<e2>", "period", ")", "and", "led", "to", "reduced", "levels", "of", "C0242723#ent", "<e1>", "throughout", "the", "period", "of", "infection", "."], "h": {"id": "C0242723", "name": "C0242723#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0043440", "name": "C0043440#ent", "pos": [14, 15]}}
{"token": ["Comparison", "of", "amino", "acid", "sequences", "that", "C1423518#ent", "<e1>", "is", "highly", "C1512488#ent", "<e2>", "to", "ADAM2", "and", "ADAM3", ",", "sperm", "surface", "proteins", "for", "fertilization", "."], "h": {"id": "C1423518", "name": "C1423518#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [10, 11]}}
{"token": ["Vaccines", "are", "needed", "against", "urinary", "tract", "infections", "C0042029#ent", "<e1>", ")", "in", "children", ",", "as", "C0034186#ent", "<e2>", "PN", ")", "may", "cause", "renal", "scarring"], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [14, 15]}}
{"token": ["Individuals", "with", "alcohol", "dependence", "less", "likely", "to", "possess", "variant", "C0002085#ent", "<e1>", "of", "the", "alcohol-metabolizing", "genes", ",", "C0001985#ent", "<e2>", "ALDH2", "*", "2", ")", "and", "alcohol", "dehydrogenase", "ADH1B*2", ")", ",", "than", "non-alcohol-dependent", "controls", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001985", "name": "C0001985#ent", "pos": [16, 17]}}
{"token": ["The", "different", "TATA-boxes", "described", "in", "the", "human", "C0026902#ent", "<e1>", "also", "identified", "in", "the", "chimpanzee", "sequence", "an", "C1412821#ent", "<e2>", "ORF", ")", "was", "observed", "which", "overlaps", "the", "chimpanzee", "c-myc", "first", "exon", "."], "h": {"id": "C0026902", "name": "C0026902#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [16, 17]}}
{"token": ["Patient", "1", "an", "adolescent", "girl", "with", "systemic", "onset", "C3714757#ent", "<e1>", "JRA", ")", "presented", "like", "severe", "C0243026#ent", "<e2>", "with", "shock", ",", "hepatic", "dysfunction", "coagulopathy", "."], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "15", "mg", "meloxicam", "is", "an", "effective", "and", "well-tolerated", "therapy", "for", "C0029408#ent", "<e1>", "and", "compares", "favorably", "with", "C0700583#ent", "<e2>", "100", "mg", ",", "a", "well-established", "treatment", "for", "this", "indication", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [18, 19]}}
{"token": ["Using", "the", "beta", "2-selective", "beta-adrenoceptor", "agonist", "salbutamol", ",", "under", "the", "same", "conditions", ",", "resulted", "in", "consistent", "C1839576#ent", "<e1>", "values", "for", "the", "nonselective", "C0001644#ent", "<e2>", "blocking", "drug", "propranolol", "some", "concentrations", "of", "the", "beta", "2-selective", "blocking", "drug", "ICI", "."], "h": {"id": "C1839576", "name": "C1839576#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [22, 23]}}
{"token": ["SPG", "was", "a", "macrophage", "C0304402#ent", "<e1>", "which", "was", "not", "C0026249#ent", "<e2>", "to", "lymphocytes", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [9, 10]}}
{"token": ["Although", "the", "cDNA-deduced", "amino", "acid", "sequence", "of", "the", "precursor", "of", "proteinase", "A", "an", "N-terminal", "signal", "peptide", "the", "C0014442#ent", "<e1>", "was", "not", "found", "in", "vacuoles", "whereas", "the", "other", "papain-like", "C0034931#ent", "<e2>", "showed", "vacuolar", "localization"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0034931", "name": "C0034931#ent", "pos": [28, 29]}}
{"token": ["However", ",", "some", "complications", "have", "been", "reported", "such", "as", "bone", "demineralization", "to", "vitamin", "D", "deficiency", "hair", "loss", "to", "C0235950#ent", "<e1>", "hemeralopia", "from", "C0042842#ent", "<e2>"], "h": {"id": "C0235950", "name": "C0235950#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0042842", "name": "C0042842#ent", "pos": [22, 23]}}
{"token": ["Enrichment", "of", "C0020289#ent", "<e1>", "activities", "(", "aryl", "sulfatase", "N-acetyl-beta-glucosaminidase", ",", "tartrate-sensitive", "acid", "phosphatase", "and", "cholesteryl", "ester", "acid", "hydrolase", "and", "C0007427#ent", "<e2>", "also", "comparable", "in", "early", "and", "late", "endosomes", "was", "considerably", "lower", "in", "the", "receptor-recycling", "fraction"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [19, 20]}}
{"token": ["Amongst", "this", "broad", "spectrum", "of", "small", "lysosomes", "the", "distribution", "of", "cathepsin", "B", "together", "with", "other", "C0020289#ent", "<e1>", "associated", "with", "more", "rapidly", "sedimenting", "lysosomes", "whilst", "C0007427#ent", "<e2>", "in", "being", "associated", "with", "slowest", "sedimenting", "lysosomes", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "the", "effect", "of", "AtBI-1", "on", "calcium", "homeostasis", "we", "evaluated", "sensitivity", "against", "cyclopiazonic", "acid", "C3812677#ent", "<e1>", ")", ",", "an", "inhibitor", "of", "C1412638#ent", "<e2>", "ATPase", "in", "AtBI-1-overexpressing", "or", "knock-down", "transgenic", "Arabidopsis", "plants", "."], "h": {"id": "C3812677", "name": "C3812677#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412638", "name": "C1412638#ent", "pos": [22, 23]}}
{"token": ["The", "effects", "of", "mycotoxin", ",", "cyclopiazonic", "acid", "C3812677#ent", "<e1>", ")", ",", "on", "the", "contractile", "function", "rat", "aortic", "smooth", "muscle", "rings", "investigated", "to", "test", "the", "hypothesis", "that", "C3812677#ent", "<e1>", "selectively", "inhibits", "the", "C1412638#ent", "<e1>"], "h": {"id": "C3812677", "name": "C3812677#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412638", "name": "C1412638#ent", "pos": [31, 32]}}
{"token": ["Ryanodine", ",", "a", "selective", "ryanodine", "receptor", "blocker", "cyclopiazonic", "acid", "C3812677#ent", "<e1>", ")", ",", "an", "inhibitor", "of", "C1412638#ent", "<e2>", "abolished", "the", "transient", "contraction", ",", "when", "pH", "was", "decreased", "in", "Ca(2+)-free", "solution", "."], "h": {"id": "C3812677", "name": "C3812677#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412638", "name": "C1412638#ent", "pos": [16, 17]}}
{"token": ["NF-kappa", "B", "activation", "induced", "by", "okadaic", "acid", "calyculin", "A", "not", "blocked", "by", "a", "C1334539#ent", "<e1>", "but", "was", "prevented", "by", "a", "C0033607#ent", "<e2>"], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [20, 21]}}
{"token": ["MT", "movement", "was", "not", "inhibited", "when", "MT", "assembly", "was", "suppressed", "with", "nocodazole", "or", "Taxol", ";", "MT", "movement", "was", "suppressed", "by", "inhibition", "of", "C1334539#ent", "<e1>", "ML7", "or", "by", "a", "C0033607#ent", "<e2>"], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [28, 29]}}
{"token": ["C0000970#ent", "<e1>", "was", "without", "effect", "on", "potassium", "homeostasis", "on", "the", "excretion", "of", "C0752224#ent", "<e2>", "proteins", "in", "urine", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752224", "name": "C0752224#ent", "pos": [12, 13]}}
{"token": ["The", "treatment", "of", "C0020514#ent", "<e1>", "has", "advanced", "in", "recent", "years", "with", "the", "introduction", "of", "C0013036#ent", "<e2>", "as", "bromcriptin", "which", "permits", "one", "to", "normalise", "prolactinemia", "and", "thus", "restore", "gonad", "function"], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013036", "name": "C0013036#ent", "pos": [14, 15]}}
{"token": ["This", "study", "illustrates", "the", "efficacy", "of", "pergolide", "in", "treating", "C0020514#ent", "<e1>", "patients", "unable", "to", "tolerate", "other", "C0013036#ent", "<e2>", "bromocriptine", ",", "lisuride", ")", "."], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013036", "name": "C0013036#ent", "pos": [16, 17]}}
{"token": ["The", "natural", "abundance", "spectra", "of", "tropine", ",", "C1161352#ent", "<e1>", ",", "scopolamine", ",", "cocaine", ",", "C0128170#ent", "<e2>", "and", "dl-tropic", "acid", "were", "determined", "at", "22.63", "MHz", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0128170", "name": "C0128170#ent", "pos": [14, 15]}}
{"token": ["We", "also", "found", "that", "C0812291#ent", "<e1>", "could", "synergize", "with", "the", "CBP", "C1422492#ent", "<e2>", "and", "that", "this", "cooperativity", "was", "cyclin", "A/Cdk2-dependent", "."], "h": {"id": "C0812291", "name": "C0812291#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [11, 12]}}
{"token": ["The", "finding", "that", "C0812291#ent", "<e1>", "transactivation", "is", "dependent", "on", "a", "key", "C1422492#ent", "<e2>", "involved", "in", "cell", "cycle", "control", "consistent", "with", "strengthens", "the", "idea", "that", "C0812291#ent", "<e1>", "plays", "a", "crucial", "role", "as", "a", "transcription", "factor", "proliferating", "cells"], "h": {"id": "C0812291", "name": "C0812291#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [11, 12]}}
{"token": ["C0010691#ent", "<e1>", "is", "a", "hereditary", "disorder", "by", "the", "development", "of", "C0392525#ent", "<e2>"], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [10, 11]}}
{"token": ["C0010691#ent", "<e1>", "is", "a", "rare", "cause", "of", "C0392525#ent", "<e2>", "whose", "management", "presents", "a", "complex", "problem", "mainly", "due", "to", "the", "hardness", "and", "high", "recurrence", "of", "cystine", "stones"], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [7, 8]}}
{"token": ["C0155862#ent", "<e1>", "a", "serious", "complication", "during", "and", "shortly", "after", "C0021400#ent", "<e2>"], "h": {"id": "C0155862", "name": "C0155862#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [9, 10]}}
{"token": ["In", "1998", ",", "an", "estimated", "3400", "older", "persons", "died", "from", "bacteremic", "C0155862#ent", "<e1>", "a", "common", "complication", "of", "C0021400#ent", "<e2>", ",", "or", "from", "other", "forms", "of", "invasive", "pneumococcal", "disease", "2", ")", "."], "h": {"id": "C0155862", "name": "C0155862#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "C1862939#ent", "<e1>", "ALS", ")", "with", "IgM", "antibody", "C0017082#ent", "<e2>", "GM2", "and", "GD2", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017082", "name": "C0017082#ent", "pos": [12, 13]}}
{"token": ["Elderly", "patients", "suffer", "more", "frequently", "than", "younger", "under", "pneumonia", ",", "exacerbations", "of", "C0008677#ent", "<e1>", "urinary", "tract", "infections", "well", "as", "skin", "and", "C0149778#ent", "<e2>"], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0149778", "name": "C0149778#ent", "pos": [21, 22]}}
{"token": ["In", "the", "Eker", "rat", ",", "a", "germ-line", "mutation", "the", "C1334043#ent", "<e1>", "of", "the", "human", "tuberous", "sclerosis", "gene", "Tsc2", ")", "causes", "renal", "cell", "carcinomas", "C2699119#ent", "<e2>", ")", "with", "a", "complete", "penetrance", "in", "all", "heterozygotes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2699119", "name": "C2699119#ent", "pos": [23, 24]}}
{"token": ["In", "the", "several", "days", "before", "death", ",", "two", "AIDS", "patients", "with", "C0085436#ent", "<e1>", "increased", "intracranial", "pressure", "ICP", ")", "experienced", "episodic", "C0262576#ent", "<e2>", "related", "to", "transient", "peaks", "in", "ICP", "."], "h": {"id": "C0085436", "name": "C0085436#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0262576", "name": "C0262576#ent", "pos": [20, 21]}}
{"token": ["C0751495#ent", "<e1>", ",", "incisional", "bleeding", "bleeding", "in", "the", "pleural", "space", "C0752304#ent", "<e2>", "renal", "failure", "and", "cardiovascular", "complications", "for", "most", "of", "the", "other", "complications", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752304", "name": "C0752304#ent", "pos": [10, 11]}}
{"token": ["The", "role", "of", "C0751495#ent", "<e1>", "occurring", "with", "C0752304#ent", "<e2>", "unclear", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752304", "name": "C0752304#ent", "pos": [7, 8]}}
{"token": ["The", "C3540017#ent", "<e1>", "included", "those", "required", "for", "glutathione", "synthesis", "gamma-glutamylcysteine", "synthetase", "C1415327#ent", "<e2>", "as", "well", "as", "glutathione-S-transferase", ",", "glutathione", "peroxidase", "glutathione", "reductase"], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415327", "name": "C1415327#ent", "pos": [11, 12]}}
{"token": ["This", "study", "describes", "the", "exact", "location", "of", "alpha", "6", "beta", "4", "and", "C1334087#ent", "<e1>", "that", "their", "responses", "in", "C0007785#ent", "<e2>", "relevant", "to", "astrocyte-matrix", "interactions", "."], "h": {"id": "C1334087", "name": "C1334087#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [18, 19]}}
{"token": ["C1705662#ent", "<e1>", "as", "a", "PT-fluorescence", "probe", "is", "applied", "to", "human", "serum", "albumin", "C0304925#ent", "<e2>", ")", "and", "beaver", "apomyoglobin", "."], "h": {"id": "C1705662", "name": "C1705662#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304925", "name": "C0304925#ent", "pos": [12, 13]}}
{"token": ["Gene", "classes", "not", "C1134446#ent", "<e1>", "include", "most", "repair", "protein", "genes", "virtually", "all", "vitamin", "biosynthesis", "genes", "C1417679#ent", "<e2>", "of", "two-component", "sensor", "systems", ",", "most", "regulatory", "genes", "and", "most", "C1417679#ent", "<e2>", "expressed", "in", "stationary", "phase", "during", "starvation", "."], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["Expression", "of", "the", "cytochrome", "P450", "1A1", "CYP1A1", ")", "and", "1B1", "(", "CYP1B1", ")", ",", "C1134446#ent", "<e1>", "mEH", ")", ",", "and", "glutathione", "S-transferase", "P1", "GSTP1", ")", "C1417679#ent", "<e2>", "was", "measured", "by", "quantitative", "reverse", "transcriptase-polymerase", "chain", "reaction"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [25, 26]}}
{"token": ["Human", "C0534137#ent", "<e1>", "CYP2B6", ")", "metabolizes", "the", "C0010583#ent", "<e2>", "CPA", ")", "to", "produce", "phosphoramide", "mustard", "cross-links", "DNA", "to", "cell", "death"], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [1, 2]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [7, 8]}}
{"token": ["Rat", "liver", "microsomes", "were", "assayed", "for", "total", "C0534137#ent", "<e1>", "content", ",", "reduced", "nicotinamide", "adenine", "dinucleotide", "phosphate-P450-reductase", "aminopyrine", "demethylase", "C0010583#ent", "<e2>", "aniline", "hydroxylase", "androstenedione", "6", "beta-", "and", "16", "alpha-hydroxylase", "and", "delta", "4", "-", "3-oxo-steroid", "5", "alpha-oxidoreductase", "activity"], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [18, 19]}}
{"token": ["Additionally", ",", "the", "proteinase", "K", "sodium", "carbonate", "treatments", "of", "the", "mitoplasts", "revealed", "that", "C1120861#ent", "<e1>", "is", "integrally", "and", "C1413137#ent", "<e2>", "is", "peripherally", "embedded", "to", "the", "outer", "surface", "of", "inner", "mitochondrial", "membrane"], "h": {"id": "C1120861", "name": "C1120861#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413137", "name": "C1413137#ent", "pos": [18, 19]}}
{"token": ["Proteolysis", "of", "nuclear", "proteins", "either", "C1120861#ent", "<e1>", "or", "m-calpain", "was", "inhibited", "by", "C1413137#ent", "<e2>", "."], "h": {"id": "C1120861", "name": "C1120861#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413137", "name": "C1413137#ent", "pos": [12, 13]}}
{"token": ["Since", "purified", "m-", "or", "C1120861#ent", "<e1>", "degraded", "NF-kappaB", "p65", "in", "vitro", "it", "is", "possible", "that", "C1413137#ent", "<e2>", "suppressed", "calpain-mediated", "degradation", "of", "NF-kappaB", "p65"], "h": {"id": "C1120861", "name": "C1120861#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413137", "name": "C1413137#ent", "pos": [15, 16]}}
{"token": ["Among", "the", "AIDS", "defining", "manifestations", ",", "Pneumocystis", "carinii", "pneumonia", "the", "commonest", "(", "50", "%", ")", ",", "followed", "by", "C0041296#ent", "<e1>", "(", "21", "%", ")", ",", "oro-esophageal", "candidiasis", "cryptosporidiosis", "and", "C0085315#ent", "<e2>", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0085315", "name": "C0085315#ent", "pos": [29, 30]}}
{"token": ["Serologic", "analyses", "rarely", "indicated", "C0041296#ent", "<e1>", "or", "streptococcal", "infections", "but", "frequently", "showed", "C0085315#ent", "<e2>", "and", "viral", "diseases"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085315", "name": "C0085315#ent", "pos": [12, 13]}}
{"token": ["We", "measured", "monoamine", "metabolites", "and", "biopterin", "in", "the", "CSF", "of", "37", "patients", "with", "dementia", "of", "the", "C1843013#ent", "<e1>", "DAT", ")", ",", "with", "or", "without", "C0234133#ent", "<e2>", "and", "in", "14", "age-matched", "healthy", "controls"], "h": {"id": "C1843013", "name": "C1843013#ent", "pos": [16, 17]}, "relation": "has_manifestation", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [24, 25]}}
{"token": ["NOS", "activity", "was", "unaffected", "by", "two", "other", "H1-antagonists", ",", "diphenhydramine", "and", "C0085170#ent", "<e1>", ",", "or", "by", "the", "structurally", "related", "C0354872#ent", "<e2>", "."], "h": {"id": "C0085170", "name": "C0085170#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0354872", "name": "C0354872#ent", "pos": [19, 20]}}
{"token": ["Increased", "inclusion", "of", "EDA", "and", "EDB", ",", "which", "can", "be", "elicited", "by", "C1366557#ent", "<e1>", ",", "may", "be", "conducive", "to", "the", "development", "of", "C1417247#ent", "<e2>", "(", "GS", ")", "."], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417247", "name": "C1417247#ent", "pos": [22, 23]}}
{"token": ["We", "propose", "that", "an", "early", "and", "transient", "nonresponsive", "immune", "condition", "the", "host", "mediated", "by", "this", "C0071533#ent", "<e1>", "required", "for", "establishing", "a", "successful", "C0151317#ent", "<e2>", "Brucella", "."], "h": {"id": "C0071533", "name": "C0071533#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0151317", "name": "C0151317#ent", "pos": [22, 23]}}
{"token": ["The", "resting", "and", "exertional", "haemodynamic", "effects", "acute", "and", "chronic", "discontinuous", "one", "tablet", "every", "6", "h", ")", "treatment", "with", "5", "mg", "of", "C0017887#ent", "<e1>", "BN", ")", "have", "been", "assessed", "in", "nine", "C0027051#ent", "<e2>", "patients", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [30, 31]}}
{"token": ["Three", "years", "later", "she", "developed", "C0521614#ent", "<e1>", "the", "subsequent", "development", "of", "a", "C0030299#ent", "<e2>"], "h": {"id": "C0521614", "name": "C0521614#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030299", "name": "C0030299#ent", "pos": [12, 13]}}
{"token": ["There", "are", "numerous", "disorders", ",", "including", "a", "number", "of", "endocrine", "disorders", "such", "as", "Cushing's", "syndrome", "hypothyroidism", ",", "and", "C0039082#ent", "<e1>", "such", "as", "Prader-Labhard-Willi", "syndrome", "C0752166#ent", "<e2>", "that", "can", "present", "with", "obesity", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0752166", "name": "C0752166#ent", "pos": [24, 25]}}
{"token": ["The", "demonstration", "that", "many", "C0003392#ent", "<e1>", "induce", "apoptosis", "in", "susceptible", "cells", "the", "possibility", "that", "factors", "affecting", "C0534519#ent", "<e2>", "activation", "and", "activity", "might", "be", "important", "determinants", "of", "anticancer", "drug", "sensitivity"], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "this", "C1333237#ent", "<e1>", "appears", "to", "be", "'", "constitutive", "'", "in", "human", "C3887624#ent", "<e2>", "and", "a", "modest", "elevation", "of", "beta-polymerase", "activity", "is", "associated", "with", "ataxia", "telangiectasia"], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [13, 14]}}
{"token": ["The", "study", "presents", "the", "long-term", "results", "of", "operative", "treatment", "spastic", "subluxation", "and", "dislocation", "of", "hip", "joints", "C0394007#ent", "<e1>", "children", "with", "open", "reduction", "pelvic", "transiliac", "osteotomy", "by", "C1823185#ent", "<e2>", "."], "h": {"id": "C0394007", "name": "C0394007#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1823185", "name": "C1823185#ent", "pos": [26, 27]}}
{"token": ["In", "conclusion", ",", "the", "use", "of", "anti-TNF", "agents", "been", "associated", "with", "increasing", "number", "of", "cases", "of", "autoimmune", "diseases", "principally", "C0262988#ent", "<e1>", "lupus-like", "syndrome", "SLE", ",", "and", "C0206062#ent", "<e2>"], "h": {"id": "C0262988", "name": "C0262988#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0206062", "name": "C0206062#ent", "pos": [26, 27]}}
{"token": ["C0633225#ent", "<e1>", "MDA", "levels", "decrease", "significantly", "through", "C0008845#ent", "<e2>", "treatment", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008845", "name": "C0008845#ent", "pos": [7, 8]}}
{"token": ["In", "the", "present", "study", ",", "we", "planned", "to", "evaluate", "C0633225#ent", "<e1>", "MDA", "levels", "of", "patients", "with", "PE", "before", "and", "after", "C0008845#ent", "<e2>", "treatment", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008845", "name": "C0008845#ent", "pos": [20, 21]}}
{"token": ["And", "C1161334#ent", "<e1>", "the", "growth", "of", "Staphylococcus", "aureus", "C0302358#ent", "<e2>"], "h": {"id": "C1161334", "name": "C1161334#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0302358", "name": "C0302358#ent", "pos": [8, 9]}}
{"token": ["In", "acute", "measles", "infection", ",", "C0025007#ent", "<e1>", "genome", "was", "detected", "in", "all", "cell", "fractions", "CD4", ",", "C1706438#ent", "<e2>", ",", "B", "cells", "and", "monocytes/macrophages", "by", "the", "H", "gene", "nested", "PCR"], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [16, 17]}}
{"token": ["In", "a", "model", "of", "C0020541#ent", "<e1>", "previously", "showed", "dynamic", "changes", "in", "the", "expression", "of", "C1417581#ent", "<e2>", "isoforms", "in", "the", "portal", "vein", "upstream", "mesenteric", "artery"], "h": {"id": "C0020541", "name": "C0020541#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417581", "name": "C1417581#ent", "pos": [14, 15]}}
{"token": ["In", "response", "to", "C0020541#ent", "<e1>", "induced", "by", "PV", "ligature", ",", "abundance", "of", "C1417581#ent", "<e2>", "in", "PV", "and", "MA1", "was", "significantly", "reduced", "and", "switched", "to", "the", "LZ-positive", "isoform", "."], "h": {"id": "C0020541", "name": "C0020541#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417581", "name": "C1417581#ent", "pos": [12, 13]}}
{"token": ["fat", "thickness", "C4049601#ent", "<e1>", "was", "less", "effective", "for", "use", "in", "classifying", "carcasses", "into", "C0234233#ent", "<e2>", "however", ",", "C4049601#ent", "<e1>", "values", "below", "6.2", "were", "associated", "with", "reduction", "in", "tenderness", "variation", "."], "h": {"id": "C4049601", "name": "C4049601#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0234233", "name": "C0234233#ent", "pos": [13, 14]}}
{"token": ["The", "dog", "appeared", "to", "develop", "transient", "C0405580#ent", "<e1>", "after", "surgery", ",", "but", "recovered", "with", "short-term", "exogenous", "C3536709#ent", "<e2>", "administration", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [16, 17]}}
{"token": ["Treatment", "with", "corticosteroids", "can", "relieve", "the", "patient's", "symptoms", "of", "C0405580#ent", "<e1>", "give", "them", "the", "C3536709#ent", "<e2>", "levels", "needed", "to", "fight", "their", "infection", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [14, 15]}}
{"token": ["C0064494#ent", "<e1>", "was", "found", "to", "be", "a", "potential", "cyclooxygenase", "(COX)-1", "and", "C1705323#ent", "<e2>", "inhibitor", "."], "h": {"id": "C0064494", "name": "C0064494#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [11, 12]}}
{"token": ["C0062021#ent", "<e1>", "also", "protective", "against", "C0751495#ent", "<e2>", "and", "lethality", "induced", "by", "4-aminopyridine", ",", "kainate", "and", "AMPA", ",", "but", "not", "by", "NMDA", ",", "whereas", "NBQX", "was", "ineffective", "in", "these", "chemoconvulsant", "tests"], "h": {"id": "C0062021", "name": "C0062021#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [5, 6]}}
{"token": ["At", "48-h", "differentiation", ",", "the", "expressions", "of", "MyoD", ",", "C1420626#ent", "<e1>", "and", "myogenin", "were", "dramatically", "increased", "in", "cells", "that", "C3890227#ent", "<e2>", "decorin", "."], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3890227", "name": "C3890227#ent", "pos": [19, 20]}}
{"token": ["A", "48-year-old", "actively", "homosexual", "man", "who", "had", "undergone", "liver", "transplantation", "cirrhosis", "secondary", "to", "C0019163#ent", "<e1>", "years", "previously", "presented", "with", "a", "C0039082#ent", "<e2>", "of", "diffuse", "pain", "cholestasis", ",", "and", "low-grade", "fever"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [20, 21]}}
{"token": ["To", "study", "the", "relationship", "between", "the", "infection", "of", "hepatitis", "B", "virus", "C0019163#ent", "<e1>", ")", "in", "gastric", "mucosa", "the", "C0039082#ent", "<e2>", "of", "disharmony", "between", "liver", "and", "stomach", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "C1335290#ent", "<e1>", "is", "required", "to", "confer", "both", "diazoxide", "and", "C1705556#ent", "<e2>", "sensitivity", "on", "Kir6.1", "."], "h": {"id": "C1335290", "name": "C1335290#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [12, 13]}}
{"token": ["The", "activity", "of", "the", "K(ATP", ")", "channel", ",", "composed", "of", "C1335290#ent", "<e1>", "and", "Kir6.2", "subunits", ",", "is", "regulated", "by", "intracellular", "C1705556#ent", "<e2>", "and", "ADP", ",", "but", "the", "molecular", "mechanism", "not", "clear", "."], "h": {"id": "C1335290", "name": "C1335290#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [20, 21]}}
{"token": ["2", ")", "The", "affinities", "of", "NBF1", "of", "C1335290#ent", "<e1>", "for", "C1705556#ent", "<e2>", "and", "ADP", ",", "especially", "for", "C1705556#ent", "<e2>", ",", "were", "significantly", "higher", "than", "those", "of", "SUR2A", "and", "SUR2B", "."], "h": {"id": "C1335290", "name": "C1335290#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["An", "unusual", "feature", "was", "the", "occurrence", "of", "severe", "Staphylococcus", "aureus", "folliculitis", "C2980105#ent", "<e1>", ",", "a", "phenomenon", "rarely", "encountered", "in", "pityriasis", "rubra", "pilaris", "the", "other", "C0334063#ent", "<e2>"], "h": {"id": "C2980105", "name": "C2980105#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0334063", "name": "C0334063#ent", "pos": [24, 25]}}
{"token": ["Restriction", "enzyme", "of", "representative", "mutant", "C0011522#ent", "<e1>", "by", "Southern", "hybridization", "transposon", "DNA", "probes", "eight", "different", "mutated", "C0678933#ent", "<e2>", "the", "five", "phenotypic", "classes", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0678933", "name": "C0678933#ent", "pos": [16, 17]}}
{"token": ["Fab-7", "may", "be", "related", "to", "insulator", "C0011522#ent", "<e1>", ",", "which", "flank", "C0678933#ent", "<e2>", "functionally", "isolate", "neighboring", "genes", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0678933", "name": "C0678933#ent", "pos": [11, 12]}}
{"token": ["Non-overlapping", "deletions", "involving", "either", "the", "5", "'", "or", "3", "'", "end", "of", "the", "gene", "were", "found", "in", "two", "patients", ",", "identifying", "C2698835#ent", "<e1>", "as", "the", "C0019247#ent", "<e2>"], "h": {"id": "C2698835", "name": "C2698835#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [25, 26]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "central", "sensitization", "CS", ")", "in", "C0009088#ent", "<e1>", "compare", "this", "phenomenon", "between", "chronic", "migraine", "CM", ")", "and", "C0393738#ent", "<e2>", "CTTH", ")", "."], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0393738", "name": "C0393738#ent", "pos": [24, 25]}}
{"token": ["The", "analysis", "of", "the", "data", "primarily", "focused", "on", "attack-type", "headaches", "(", "migraine", ",", "C0009088#ent", "<e1>", "and", "episodic", "tension-type", "headache", "and", "chronic", "or", "daily", "headaches", "(", "C0393738#ent", "<e2>", "migraine", "combined", "with", "tension-type", "headache", "."], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0393738", "name": "C0393738#ent", "pos": [25, 26]}}
{"token": ["The", "criteria", "of", "the", "International", "Headache", "Society", "(", "IHS", ")", "define", "four", "different", "primary", "headache", "syndromes", "daily", "C0009088#ent", "<e1>", "chronic", "migraine", "episodic", "and", "C0393738#ent", "<e2>", "hemicrania", "continua", "new", "daily", "persisting", "headache", "."], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0393738", "name": "C0393738#ent", "pos": [23, 24]}}
{"token": ["The", "sulphinic", "acid", "analogue", "of", "GABA", ",", "C0062942#ent", "<e1>", ",", "was", "found", "to", "be", "a", "potent", "partial", "C0243192#ent", "<e2>", "(", "KD", "=", "4.59", "microM", ",", "intrinsic", "activity", "%", ")", "."], "h": {"id": "C0062942", "name": "C0062942#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "the", "effect", "of", "aerosol", "administration", "C0133777#ent", "<e1>", "on", "bronchial", "hyperresponsiveness", "evaluated", "in", "ten", "inpatients", "with", "C0155880#ent", "<e2>"], "h": {"id": "C0133777", "name": "C0133777#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0155880", "name": "C0155880#ent", "pos": [19, 20]}}
{"token": ["These", "data", "are", "similar", "to", "those", "reported", "for", "naturally", "occurring", "C0006864#ent", "<e1>", "such", "as", "C0039663#ent", "<e2>", "cannabidiol", "."], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [10, 11]}, "relation": "structural_class_of", "t": {"id": "C0039663", "name": "C0039663#ent", "pos": [14, 15]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "C0006864#ent", "<e1>", "and", "opioid", "mediated", "regulation", "on", "the", "effects", "of", "central", "Delta(9)-tetrahydrocannabinol", "C0039663#ent", "<e2>", ")", "administration", "on", "hypothalamus-pituitary-adrenal", "(", ")", "axis", "activity", "the", "male", "rat", "."], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [9, 10]}, "relation": "structural_class_of", "t": {"id": "C0039663", "name": "C0039663#ent", "pos": [21, 22]}}
{"token": ["C0006864#ent", "<e1>", "such", "as", "C0039663#ent", "<e2>", "(", "delta(9)-THC", ")", "or", "WIN-55,212", "-", "2", "(", "WIN-2", ")", "have", "psychoactive", "effects", "cognition", "."], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0039663", "name": "C0039663#ent", "pos": [4, 5]}}
{"token": ["We", "aimed", "to", "compare", "the", "effects", "of", "carvedilol", "and", "C0724633#ent", "<e1>", "left", "atrial", "(", "LA", ")", "function", "in", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0724633", "name": "C0724633#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["Our", "observations", "suggest", "that", "neuronal", "interaction", "with", "these", "C0072522#ent", "<e1>", "may", "involve", "C1880904#ent", "<e2>", "components", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [12, 13]}}
{"token": ["The", "results", "suggest", "that", "C0015772#ent", "<e1>", "can", "attenuate", "C0004153#ent", "<e2>", ",", "and", "this", "effect", "is", "partly", "related", "to", "inhibition", "of", "oxidative", "stress", "inflammatory", "signal-transduction", "pathways", "which", "lead", "to", "decreases", "in", "the", "expression", "of", "inflammatory", "cytokines"], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [8, 9]}}
{"token": ["The", "results", "from", "the", "Felodipine", "Atherosclerosis", "Prevention", "Study", "will", "provide", "valuable", "information", "about", "the", "effect", "of", "C0015772#ent", "<e1>", "alone", "and", "in", "combination", "with", "simvastatin", "on", "progression", "of", "C0004153#ent", "<e2>", "evaluated", "noninvasively", "."], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [27, 28]}}
{"token": ["The", "mRNAs", "targetted", "were", "the", "flip", "and", "flop", "isoforms", "GluR1", "and", "GluR2", ",", "KA1", "and", "C1415297#ent", "<e1>", ",", "NR1", ",", "and", "the", "glutamate", "binding", "protein", "C3539609#ent", "<e2>", ")", "."], "h": {"id": "C1415297", "name": "C1415297#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3539609", "name": "C3539609#ent", "pos": [25, 26]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "benefit", "of", "C0242699#ent", "<e1>", "fibronectin", "application", "in", "the", "surgical", "treatment", "severe", ",", "naturally", "occurring", "C0031090#ent", "<e2>", "Beagle", "dogs"], "h": {"id": "C0242699", "name": "C0242699#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [23, 24]}}
{"token": ["Recently", ",", "serum", "antibodies", "patients", "with", "C0079293#ent", "<e1>", "have", "been", "reported", "to", "bind", "to", "the", "carboxyl", "terminus", "of", "type", "VII", "collagen", "the", "C0012634#ent", "<e2>"], "h": {"id": "C0079293", "name": "C0079293#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}}
{"token": ["Neurological", "examination", "C0020429#ent", "<e1>", "and", "hypesthesia", "on", "his", "left", "face", "C0151311#ent", "<e2>", "left-sided", "hearing", "loss"], "h": {"id": "C0020429", "name": "C0020429#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0151311", "name": "C0151311#ent", "pos": [10, 11]}}
{"token": ["This", "triad", ",", "otitis", "media", "C0025297#ent", "<e1>", ",", "focal", "cerebral", "lesion", "with", "systemic", "manifestations", "inflammation", ",", "C0014457#ent", "<e2>", "cerebrospinal", "fluid", "should", "suggest", "eosinophilic", "granuloma", "the", "differential", "diagnosis"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [16, 17]}}
{"token": ["IP-10", "(", "CXCL10", ")", "and", "C1707170#ent", "<e1>", "(", "CXCL9", ")", "are", "T-cell", "chemoattractants", "have", "C0290149#ent", "<e2>", "properties", "."], "h": {"id": "C1707170", "name": "C1707170#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0290149", "name": "C0290149#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "we", "found", "a", "significant", "positive", "correlation", "to", "the", "expression", "of", "the", "C0003015#ent", "<e1>", "(", "p", "=", "0.04", ")", "and", "C1332737#ent", "<e2>", "(", "p", "=", "0.024", ")", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [22, 23]}}
{"token": ["These", "are", "non-LTR", "retrotransposons", "group", "II", "introns", "that", "encode", "C0035379#ent", "<e1>", "and", "group", "I", "introns", "and", "C0524967#ent", "<e2>", "encode", "homing", "endonuclease", "genes", "HEGs", ")", "."], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0524967", "name": "C0524967#ent", "pos": [16, 17]}}
{"token": ["This", "report", "provides", "information", "on", "the", "use", "of", "PDT", "for", "C1290884#ent", "<e1>", "disorders", "of", "the", "pilosebaceous", "unit", "infections", "of", "the", "skin", ",", "C0036412#ent", "<e2>", "cosmetic", "indications"], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036412", "name": "C0036412#ent", "pos": [22, 23]}}
{"token": ["Members", "of", "the", "small", "Maf", "family", "MafK", ",", "C1416967#ent", "<e1>", ",", "and", "MafG", ")", "are", "basic", "C0079686#ent", "<e2>", "bZip", ")", "proteins", "that", "can", "function", "as", "transcriptional", "activators", "repressors", "."], "h": {"id": "C1416967", "name": "C1416967#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079686", "name": "C0079686#ent", "pos": [16, 17]}}
{"token": ["Inhibition", "of", "C0282625#ent", "<e1>", "PI", "3-kinase", "inhibited", "ET-1-induced", "activation", "of", "the", "C0026249#ent", "<e2>", "activated", "protein", "kinase", "family", "member", "extracellular", "signal-regulated", "kinase", "ERK", ")", "1", "."], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "CHOP", "is", "under", "the", "control", "of", "the", "C1414860#ent", "<e1>", "promoter", "and", "the", "C1852061#ent", "<e2>", "the", "5'-terminal", "part", "of", "C1414860#ent", "<e1>", "which", "provides", "a", "transcriptional", "activation", "function"], "h": {"id": "C1852061", "name": "C1852061#ent", "pos": [14, 15]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1414860", "name": "C1414860#ent", "pos": [9, 10]}}
{"token": ["The", "diagnosis", "of", "this", "family", "was", "established", "by", "detection", "of", "a", "missense", "mutation", "the", "C1335193#ent", "<e1>", "the", "PAX", "6", "C0079429#ent", "<e2>", ",", "hence", "conforming", "to", "a", "forme", "fruste", "congenital", "aniridia"], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "C1335193#ent", "<e1>", "well", "as", "in", "PRDM1", "C0079429#ent", "<e2>", "have", "been", "recently", "implicated", "in", "lymphomas", "."], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}}
{"token": ["There", "is", "a", "noticeably", "elevated", "level", "of", "mutation", "in", "the", "C1335193#ent", "<e1>", "with", "the", "rest", "of", "the", "C0079429#ent", "<e2>", "."], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}}
{"token": ["Breaks", "in", "Arrhenius", "plots", "for", "activities", "of", "C1522419#ent", "<e1>", "and", "P-450(17", ")", "alpha", ",", "C0024188#ent", "<e2>", "correlate", "with", "transition", "temperatures", "for", "the", "microsomal", "membrane"], "h": {"id": "C1522419", "name": "C1522419#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024188", "name": "C0024188#ent", "pos": [14, 15]}}
{"token": ["In", "liposomes", "containing", "NADPH-cytochrome", "P-450", "reductase", "C1522419#ent", "<e1>", "or", "P-450(17", ")", "alpha", ",", "C0024188#ent", "<e2>", ",", "addition", "of", "a", "small", "amount", "of", "cytochrome", "b5", "stimulated", "the", "hydroxylase", "activity", "a", "large", "amount", "of", "cytochrome", "b5", "suppressed", "the", "hydroxylase", "activity"], "h": {"id": "C1522419", "name": "C1522419#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024188", "name": "C0024188#ent", "pos": [13, 14]}}
{"token": ["IL-2", "deprivation-induced", "activation", "of", "acid", "sphingomyelinase", "SMase", ")", "and", "inhibition", "of", "C1421319#ent", "<e1>", "GCS", ")", "and", "C0209748#ent", "<e2>", "SMS", ")", "were", "normalized", "by", "IL-2", "supplementation", "."], "h": {"id": "C1421319", "name": "C1421319#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0209748", "name": "C0209748#ent", "pos": [16, 17]}}
{"token": ["We", "also", "report", "that", "mouse", "TAP1", "begins", "172", "C3539946#ent", "<e1>", "of", "the", "previously", "published", "start", "site", "report", "the", "genomic", "organization", "mouse", "C1332447#ent", "<e2>", "and", "Tap-2", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [21, 22]}}
{"token": ["Ethanol", "(", "2", "g/kg", ",", "C1419070#ent", "<e1>", ")", "offered", "protection", "against", "these", "C0991617#ent", "<e2>", ",", "and", "it", "was", "most", "effective", "against", "picrotoxin", "and", "least", "effective", "against", "kainic", "acid"], "h": {"id": "C1419070", "name": "C1419070#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [12, 13]}}
{"token": ["Comparison", "was", "made", "between", "intraperitoneal", "(", "C1419070#ent", "<e1>", ")", "versus", "intralesional", "(", "IL", ")", "administration", "of", "these", "C0991617#ent", "<e2>", "."], "h": {"id": "C1419070", "name": "C1419070#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}}
{"token": ["Fibroblasts", "from", "patients", "with", "the", "heterozygous", "form", "of", "C0020445#ent", "<e1>", "FH", ")", "possess", "one", "functional", "C0002085#ent", "<e2>", "and", "one", "nonfunctional", "C0002085#ent", "<e2>", "at", "the", "LDL", "receptor", "locus"], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [15, 16]}}
{"token": ["Among", "patients", "with", "C0020445#ent", "<e1>", "half", "of", "the", "mutant", "C0002085#ent", "<e2>", "at", "the", "low", "density", "lipoprotein", "LDL", ")", "receptor", "locus", "produce", "no", "immunologically", "detectable", "protein", "."], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}}
{"token": ["Interestingly", ",", "the", "messenger", "RNA", "expression", "of", "dentin", "matrix", "acidic", "phosphoprotein-1", "C1415840#ent", "<e1>", "and", "ALP", "activity", "were", "significantly", "reduced", "in", "nicotine-treated", "C0068006#ent", "<e2>", "."], "h": {"id": "C1415840", "name": "C1415840#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0068006", "name": "C0068006#ent", "pos": [21, 22]}}
{"token": ["PCR", "analysis", "that", "at", "the", "initial", "clinical", "presentation", "C0019348#ent", "<e1>", "these", "patients", "was", "not", "mistaken", "for", "C0019360#ent", "<e2>", "but", "that", "C0019360#ent", "<e2>", "was", "incorrectly", "diagnosed", "as", "C0019348#ent", "<e1>", "nine", "cases", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0019360", "name": "C0019360#ent", "pos": [16, 17]}}
{"token": ["A", "steady", "rise", "of", "mortality", "from", "ischemic", "heart", "disease", "C0042373#ent", "<e1>", "the", "decline", "of", "mortality", "from", "rheumatism", "and", "C0848548#ent", "<e2>", "among", "men", "and", "women", "were", "noted", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0848548", "name": "C0848548#ent", "pos": [18, 19]}}
{"token": ["C0268731#ent", "<e1>", "accompanies", "a", "wide", "variety", "of", "C0023895#ent", "<e2>", "including", "acute", "or", "chronic", "hepatitis"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [7, 8]}}
{"token": ["In", "order", "of", "frequency", ",", "pneumonia", ",", "C0548923#ent", "<e1>", "UTI", "and", "C0004610#ent", "<e2>", "most", "common", "."], "h": {"id": "C0548923", "name": "C0548923#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [11, 12]}}
{"token": ["Some", "indices", "of", "T", "and", "B", "cellular", "immunity", "content", "of", "PgE2", "and", "C0058310#ent", "<e1>", "the", "peripheral", "blood", "plasma", "studied", "in", "70", "patients", "with", "C0010054#ent", "<e2>", "in", "22", "patients", "with", "rheumatic", "disease", "by", "chronic", "cardiac", "failure"], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [23, 24]}}
{"token": ["omega-Conotoxin", "C1706170#ent", "<e1>", "(", "1microM", ")", ",", "a", "selective", "C0001645#ent", "<e2>", "of", "N-type", "current", ",", "inhibited", "high", "threshold", "voltage-activated", "peak", "currents", "by", "28", "%", "indicating", "the", "presence", "of", "N-type", "channels"], "h": {"id": "C1706170", "name": "C1706170#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [9, 10]}}
{"token": ["Clinicians", ",", "however", ",", "often", "have", "to", "treat", "C0013395#ent", "<e1>", "or", "C0018834#ent", "<e2>", "of", "undetermined", "cause", "because", "the", "frequency", "of", "C0018834#ent", "<e2>", "increases", "during", "pregnancy", "."], "h": {"id": "C0013395", "name": "C0013395#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0018834", "name": "C0018834#ent", "pos": [11, 12]}}
{"token": ["Our", "findings", "show", "that", "contemporary", "C0071530#ent", "<e1>", ",", "PCDF", "and", "C0033223#ent", "<e2>", "levels", "have", "declined", "since", "the", "80s", "."], "h": {"id": "C0071530", "name": "C0071530#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033223", "name": "C0033223#ent", "pos": [10, 11]}}
{"token": ["Toxic", "equivalency", "factors", "(", "TEFs", ")", "for", "2,3,7,8-substituted", "polychlorinated", "dibenzo-p-dioxins", "C0071530#ent", "<e1>", ")", "and", "dibenzofurans", "(", "PCDFs", ")", "and", "coplanar", "polychlorinated", "biphenyl", "C0033223#ent", "<e2>", ")", "congeners", "have", "been", "developed", "by", "the", "World", "Health", "Organization", "WHO", ")", "."], "h": {"id": "C0071530", "name": "C0071530#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033223", "name": "C0033223#ent", "pos": [22, 23]}}
{"token": ["Dioxins", "(", "C0071530#ent", "<e1>", "+", "PCDF", ")", "and", "polychlorinated", "biphenyl", "C0033223#ent", "<e2>", ")", "are", "potentially", "hazardous", "compounds", "and", "have", "structural", "similarity", "to", "thyroid", "hormones"], "h": {"id": "C0071530", "name": "C0071530#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033223", "name": "C0033223#ent", "pos": [10, 11]}}
{"token": ["The", "discovery", "of", "an", "C0026684#ent", "<e1>", "any", "age", "should", "lead", "to", "the", "investigation", "for", "C0010674#ent", "<e2>", "."], "h": {"id": "C0026684", "name": "C0026684#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [14, 15]}}
{"token": ["Transfer", "of", "the", "plasmid", "from", "CO101", "to", "four", "other", "strains", "from", "the", "C.", "flaccumfaciens", "group", "occurred", "between", "cells", "C2350558#ent", "<e1>", "on", "nitrocellulose", "filters", "or", "on", "C0026818#ent", "<e2>", "surfaces", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [25, 26]}}
{"token": ["C0086774#ent", "<e1>", "PCH", ")", "is", "an", "C0002880#ent", "<e2>", "by", "the", "Donath-Landsteiner", "antibody"], "h": {"id": "C0086774", "name": "C0086774#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002880", "name": "C0002880#ent", "pos": [6, 7]}}
{"token": ["The", "excretory", "pattern", "for", "MK-196", "is", "ocmpatible", "with", "that", "of", "other", "weak", "C3541407#ent", "<e1>", "as", "salicylate", "and", "C0033209#ent", "<e2>", "."], "h": {"id": "C3541407", "name": "C3541407#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [17, 18]}}
{"token": ["It", "has", "been", "demonstrated", "that", "C3541407#ent", "<e1>", "as", "penicillin", ",", "C0033209#ent", "<e2>", "and", "sodium", "salicylate", "the", "reduction", "of", "EP", "normally", "observed", "after", "furosemide", "administration", "(", "Rybak", "et", "al.", ",", "1992a", ")", "."], "h": {"id": "C3541407", "name": "C3541407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [10, 11]}}
{"token": ["The", "identification", "of", "a", "number", "of", "C0599930#ent", "<e1>", "human", "skin", "prompted", "us", "to", "investigate", "the", "presence", "of", "C2698419#ent", "<e2>", "and", "SF-1", "."], "h": {"id": "C0599930", "name": "C0599930#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2698419", "name": "C2698419#ent", "pos": [17, 18]}}
{"token": ["Virulence", "of", "the", "type", "2", "isolate", "was", "confirmed", "by", "inoculation", "of", "a", "control", "bovine", "cow", "developed", "diarrhea", ",", "dehydration", ",", "C0040034#ent", "<e1>", "hemorrhages", ",", "and", "C0014335#ent", "<e2>", "with", "intestinal", "necrosis"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [25, 26]}}
{"token": ["In", "contrast", ",", "D2", "receptor", "mRNA", "levels", "were", "presented", "also", "on", "E14", ",", "increased", "to", "a", "peak", "on", "C1417248#ent", "<e1>", ",", "declined", "until", "C4284134#ent", "<e2>", ",", "and", "increased", "thereafter", "to", "adulthood", "."], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4284134", "name": "C4284134#ent", "pos": [23, 24]}}
{"token": ["This", "effect", "was", "developmentally", "regulated", ",", "being", "maximal", "(", "50", "%", ")", "between", "C1417248#ent", "<e1>", "and", "C4284134#ent", "<e2>", "and", "then", "declining", "to", "30", "%", "after", "C4284134#ent", "<e2>", "."], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4284134", "name": "C4284134#ent", "pos": [16, 17]}}
{"token": ["Conversely", ",", "Dab1", "levels", "were", "higher", "at", "C1417248#ent", "<e1>", ",", "and", "lower", "at", "C4284134#ent", "<e2>", "in", "hypothyroid", "animals", "."], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284134", "name": "C4284134#ent", "pos": [13, 14]}}
{"token": ["The", "nuclear", "sequestration", "of", "C1706586#ent", "<e1>", "was", "blocked", "by", "C0126174#ent", "<e2>", ",", "an", "AT1", "receptor-specific", "antagonist", ",", "and", "not", "by", "PD123319", ",", "an", "AT2", "receptor-specific", "antagonist", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [9, 10]}}
{"token": ["The", "C0080058#ent", "<e1>", "many", "effectors", ",", "including", "members", "of", "the", "Raf", "family", "C0033640#ent", "<e2>"], "h": {"id": "C0080058", "name": "C0080058#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [12, 13]}}
{"token": ["In", "Saccharomyces", "cerevisiae", "C0080058#ent", "<e1>", "nutrient", "availability", "to", "cell", "growth", "regulation", "of", "C0033640#ent", "<e2>", "PKA", ")", "activity", "."], "h": {"id": "C0080058", "name": "C0080058#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [12, 13]}}
{"token": ["BP", "increases", "were", "made", "by", "injecting", "10", "and", "15", "microg/kg", "boluses", "of", "C0031469#ent", "<e1>", "or", "by", "injecting", "5", "%", "C0359180#ent", "<e2>"], "h": {"id": "C0031469", "name": "C0031469#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0359180", "name": "C0359180#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "that", "diphenhydramine", "can", "prevent", "histamine-induced", "pulmonary", "edema", "and", "can", "prevent", "and", "reverse", "increased", "C1522575#ent", "<e1>", "by", "histamine", ",", "and", "that", "histamine", "effects", "on", "C1522575#ent", "<e1>", "C1332766#ent", "<e1>", "actions", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332766", "name": "C1332766#ent", "pos": [27, 28]}}
{"token": ["The", "vasopressin-", "and", "fragment-induced", "secretion", "was", "inhibited", "by", "the", "C3537128#ent", "<e1>", "and", "the", "protein", "kinase", "C", "inhibitor", "tetracaine", ",", "but", "not", "by", "the", "C0001644#ent", "<e2>"], "h": {"id": "C3537128", "name": "C3537128#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [23, 24]}}
{"token": ["The", "author", "holds", "the", "view", "that", "most", "cases", "of", "manifest", "C0017105#ent", "<e1>", "caused", "by", "C4289590#ent", "<e2>", "not", "coming", "from", "outside", "."], "h": {"id": "C0017105", "name": "C0017105#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4289590", "name": "C4289590#ent", "pos": [14, 15]}}
{"token": ["The", "results", "indicated", "that", "C0017105#ent", "<e1>", "caused", "by", "the", "C4289590#ent", "<e2>", "of", "both", "aerobic", "and", "anaerobic", "bacteria"], "h": {"id": "C0017105", "name": "C0017105#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4289590", "name": "C4289590#ent", "pos": [9, 10]}}
{"token": ["Serum", "C2936883#ent", "<e1>", "levels", "were", "higher", "in", "patients", "with", "C1623038#ent", "<e2>", "."], "h": {"id": "C2936883", "name": "C2936883#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [9, 10]}}
{"token": ["The", "efficacy", "and", "safety", "of", "C0065162#ent", "<e1>", "400", "mg", "daily", "in", "the", "treatment", "of", "complicated", "C0042029#ent", "<e2>", "confirmed", "in", "a", "randomized", "multicenter", "study", "enrolled", "294", "patients", "from", "16", "centers", "in", "Italy", "."], "h": {"id": "C0065162", "name": "C0065162#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "caution", "must", "be", "exercised", "when", "HPLC", "is", "employed", "to", "study", "C0038317#ent", "<e1>", "patients", "who", "have", "previously", "been", "exposed", "to", "C0039925#ent", "<e2>", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [21, 22]}}
{"token": ["All", "children", "were", "treated", "with", "hyperventilation", ",", "C0038317#ent", "<e1>", ",", "mannitol", "and", ",", "when", "necessary", ",", "C0039925#ent", "<e2>", "(", "TPS", ")", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [16, 17]}}
{"token": ["After", "antihistaminics", "plus", "C0038317#ent", "<e1>", "were", "given", "as", "part", "of", "a", "protocol", "treatment", "enzymatic", "antioxidant", "activities", "C0039925#ent", "<e2>", "substance", "levels", ",", "and", "carbonyl", "contents", "were", "used", "as", "recovering", "markers", "for", "the", "disease", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [16, 17]}}
{"token": ["It", "also", "suggests", "that", "all", "C1519837#ent", "<e1>", "sucrafate", ",", "misoprostol", "and", "C0085191#ent", "<e2>", "ca", "n't", "be", "recommended", "for", "gastric", "ulcer", "treatment", "."], "h": {"id": "C1519837", "name": "C1519837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085191", "name": "C0085191#ent", "pos": [11, 12]}}
{"token": ["src", "homology", "region", "and", "3", "(", "SH2", "and", "SH3)", "domains", "conserved", "noncatalytic", "regions", "described", "in", "C1366894#ent", "<e1>", "subsequently", "identified", "in", "phospholipase", "C", "gamma", "1", "C1415793#ent", "<e2>", ",", "GTPase-activating", "protein", "ras", ",", "and", "other", "signaling", "proteins"], "h": {"id": "C1366894", "name": "C1366894#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [24, 25]}}
{"token": ["C0010592#ent", "<e1>", "treatment", "for", "17", "days", "increased", "C0010762#ent", "<e2>", "content", "by", "40", "%", "with", "a", "concomitant", "elevation", "of", "the", "omega-", "and", "(omega-1)-hydroxylation", "activities", "of", "lauric", "acid"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [7, 8]}}
{"token": ["To", "mimic", "more", "closely", "the", "current", "clinical", "protocol", "hepatocyte", "cultures", "also", "co-treated", "with", "corticosteroids", "and", "C0010592#ent", "<e1>", "A", "or", "ketoconazole", "(", "a", "selective", "inhibitor", "of", "C0010762#ent", "<e2>", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [25, 26]}}
{"token": ["C0033634#ent", "<e1>", "inhibition", "blocked", "NFkappaB", "activation", "C3887648#ent", "<e2>", ",", "but", "potentiated", "CRE", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [6, 7]}}
{"token": ["The", "influence", "of", "activation", "of", "C0033634#ent", "<e1>", "PKC", ")", "and", "cyclic", "AMP", "C3887648#ent", "<e2>", "(", "NA", ")", "release", "in", "the", "neurosecretory", "rat", "pheochromocytoma", "PC12", "cell", "line", "investigated", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [12, 13]}}
{"token": ["In", "this", "report", ",", "we", "describe", "C1420295#ent", "<e1>", "patterns", "of", "C0085536#ent", "<e2>", "three", "distinct", "cell", "types", "by", "the", "v-erbB", "oncogene", "fibroblasts", ",", "erythroblasts", ",", "and", "endothelial", "cells"], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [10, 11]}}
{"token": ["In", "summary", ",", "diabetes", "appears", "to", "induce", "C1420295#ent", "<e1>", "changes", "in", "C0085536#ent", "<e2>", "and", "PSPase", "activities", "resulting", "in", "significant", "alterations", "in", "dephosphorylation", "of", "IR", "and", "glycogen", "synthase"], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [11, 12]}}
{"token": ["Six", "different", "cDNA", "fragments", "the", "PTK", "genes", "were", "isolated", ",", "and", "the", "sequence", "analysis", "that", "these", "represented", "cDNAs", "for", "C1705742#ent", "<e1>", ",", "KDR", ",", "FMS", ",", "FGFR-4", ",", "JAK1", "and", "C0084219#ent", "<e2>", "."], "h": {"id": "C1705742", "name": "C1705742#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0084219", "name": "C0084219#ent", "pos": [30, 31]}}
{"token": ["From", "stage", "22", "to", "25", "the", "number", "of", "extracellular", "C0382507#ent", "<e1>", "significantly", "greater", "in", "the", "chondrogenic", "region", "in", "the", "C2986638#ent", "<e2>", "but", "the", "number", "of", "intracellular", "C0382507#ent", "<e1>", "the", "same", "."], "h": {"id": "C0382507", "name": "C0382507#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986638", "name": "C2986638#ent", "pos": [19, 20]}}
{"token": ["These", "data", "suggest", "a", "significant", "\"", "anti-ischemic", "\"", "effect", "of", "C0599973#ent", "<e1>", "in", "myocytes", "that", "is", "accompanied", "by", "induction", "of", "72", "C1705240#ent", "<e2>", "heat", "shock", "protein"], "h": {"id": "C0599973", "name": "C0599973#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [21, 22]}}
{"token": ["Posterior", "reversible", "encephalopathy", "syndrome", "PRES", ")", "is", "a", "C1858991#ent", "<e1>", "clinically", "characterized", "by", "headache", ",", "altered", "mental", "status", "visual", "loss", "C0036572#ent", "<e2>", "."], "h": {"id": "C1858991", "name": "C1858991#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [20, 21]}}
{"token": ["Unlike", "in", "the", "case", "of", "bovine", "C0234238#ent", "<e1>", ",", "optimization", "of", "C1413374#ent", "<e2>", "glycan", "loading", "of", "the", "primate", "versions", "C0234238#ent", "<e1>", "(", "human", "or", "rhesus", ")", "did", "not", "increase", "their", "circulatory", "lifetime", "rhesus", "macaques"], "h": {"id": "C0234238", "name": "C0234238#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413374", "name": "C1413374#ent", "pos": [11, 12]}}
{"token": ["The", "close", "relationship", "between", "C0563238#ent", "<e1>", "duodenal", "ulceration", "documented", "by", "the", "high", "incidence", "of", "C1415692#ent", "<e2>", "in", "these", "patients", "(", "90", "-", "100", "%", ")", "."], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "grade", "of", "the", "infiltration", "of", "MNC", "and", "IgA", "positive", "cells", "always", "greater", "in", "DU", "than", "in", "C0563238#ent", "<e1>", ",", "regardless", "of", "the", "number", "of", "C1415692#ent", "<e2>", "."], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [28, 29]}}
{"token": ["C0563238#ent", "<e1>", "caused", "by", "Helicobacter", "pylori", "C1415692#ent", "<e2>", ")", "is", "common", "in", "patients", "with", "nonulcer", "dyspepsia", "NUD", ")", ",", "but", "an", "etiologic", "relationship", "between", "the", "histologic", "lesion", "and", "clinical", "symptoms", "unproven", "."], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [6, 7]}}
{"token": ["The", "authors", "decided", "to", "investigate", "a", "correlation", "between", "C0563238#ent", "<e1>", "and", "Hp", "infection", "a", "relationship", "between", "the", "influence", "of", "antibacterial", "therapy", "C1415692#ent", "<e2>", "eradication", "from", "gastric", "mucus", "to", "observe", "gastric", "mucosa", "condition", "."], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [21, 22]}}
{"token": ["Strains", "with", "mutations", "in", "the", "ptsH", "(", "HPr", ")", "and/or", "pts", "I", "C0027203#ent", "<e1>", "genes", "were", "selected", "on", "medium", "containing", "C0376261#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [20, 21]}}
{"token": ["This", "implies", "that", "C0133938#ent", "<e1>", "and", "E7", "may", "be", "the", "C0029016#ent", "<e2>", "HPV-16", "and", "play", "an", "important", "role", "in", "the", "carcinogenesis", "of", "human", "cervical", "epithelial", "cells"], "h": {"id": "C0133938", "name": "C0133938#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [10, 11]}}
{"token": ["C0133938#ent", "<e1>", "is", "one", "of", "major", "C0029016#ent", "<e2>", "."], "h": {"id": "C0133938", "name": "C0133938#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [6, 7]}}
{"token": ["The", "competitive", "effects", "C0037956#ent", "<e1>", "in", "the", "presence", "and", "absence", "of", "C0004855#ent", "<e2>", "also", "examined", "."], "h": {"id": "C0037956", "name": "C0037956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004855", "name": "C0004855#ent", "pos": [11, 12]}}
{"token": ["Cetirizine", ",", "a", "piperazine", "derivative", "carboxylated", "metabolite", "of", "C0020404#ent", "<e1>", ",", "is", "a", "potent", "histamine", "H1-receptor", "antagonist", "with", "C0282555#ent", "<e2>"], "h": {"id": "C0020404", "name": "C0020404#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282555", "name": "C0282555#ent", "pos": [18, 19]}}
{"token": ["Presentation", "was", "variable", ",", "consisting", "of", "cryptococcal", "meningitis", "C0276688#ent", "<e1>", "aspergillus", "cerebral", "vasculitis", "disseminated", "histoplasmosis", "from", "a", "C0032302#ent", "<e2>"], "h": {"id": "C0276688", "name": "C0276688#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032302", "name": "C0032302#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "hemodialysis", "and", "of", "ultrafiltration", "on", "intraocular", "pressure", "IOP", ")", "was", "studied", "in", "30", "non", "C0017601#ent", "<e1>", "patients", "(", "58", "eyes", ")", "with", "C1561643#ent", "<e2>"], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [25, 26]}}
{"token": ["Overexpression", "of", "exogenous", "C1424989#ent", "<e1>", "in", "FD-Fms", "cells", "dramatically", "accelerates", "macrophage", "differentiation", "upon", "C1524095#ent", "<e2>", "stimulation", "."], "h": {"id": "C1424989", "name": "C1424989#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1524095", "name": "C1524095#ent", "pos": [13, 14]}}
{"token": ["The", "assay", "is", "suitable", "for", "pharmacokinetic", "studies", "C0950252#ent", "<e1>", "and", "(S)-(-)-isomers", "of", "C0936073#ent", "<e2>", ",", "following", "usual", "bolus", "intravenous", "clinical", "doses", "of", "the", "racemic", "drug"], "h": {"id": "C0950252", "name": "C0950252#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [12, 13]}}
{"token": ["C0070915#ent", "<e1>", "also", "increased", "significantly", "the", "contraction", "to", "C0006931#ent", "<e2>", "in", "the", "presence", "of", "epithelium", ",", "without", "altering", "the", "response", "obtained", "in", "the", "absence", "of", "epithelium", "."], "h": {"id": "C0070915", "name": "C0070915#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [8, 9]}}
{"token": ["C0070915#ent", "<e1>", "did", "not", "further", "potentiate", "the", "responses", "to", "substance", "P", "to", "C0006931#ent", "<e2>", "in", "the", "infected", "animals", ",", "whereas", "it", "did", "so", "in", "noninfected", "animals", "."], "h": {"id": "C0070915", "name": "C0070915#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [12, 13]}}
{"token": ["Six", "patients", "had", "recurrent", "bacteremia", "with", "two", "to", "four", "C0004610#ent", "<e1>", "episodes", ",", "five", "had", "C0024228#ent", "<e2>", "and", "two", "had", "emm", "type", "stG840.0", "in", "every", "episode", "."], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024228", "name": "C0024228#ent", "pos": [15, 16]}}
{"token": ["Six", "patients", "had", "recurrent", "C0004610#ent", "<e1>", "with", "two", "to", "four", "bacteremic", "episodes", ",", "five", "had", "C0024228#ent", "<e2>", "and", "two", "had", "emm", "type", "stG840.0", "in", "every", "episode", "."], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024228", "name": "C0024228#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "the", "results", "suggested", "that", "C0003015#ent", "<e1>", "cyclooxygenase", "and", "lipoxygenase", "like", "C1955822#ent", "<e2>", "provide", "an", "effective", "control", "of", "inflammation", "and", "hyperalgesia", "against", "acute", "inflammation/hyperalgesia", "in", "rats", "and", "mice", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1955822", "name": "C1955822#ent", "pos": [12, 13]}}
{"token": ["C0003950#ent", "<e1>", "is", "the", "most", "frequent", "C0021832#ent", "<e2>"], "h": {"id": "C0003950", "name": "C0003950#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021832", "name": "C0021832#ent", "pos": [6, 7]}}
{"token": ["Inflammatory", "polyarthritis", "be", "a", "self-limiting", "disease", ",", "develop", "into", "C0003873#ent", "<e1>", "RA", ")", "or", "differentiate", "into", "another", "form", "of", "C0263680#ent", "<e2>"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0263680", "name": "C0263680#ent", "pos": [19, 20]}}
{"token": ["One", "of", "the", "striking", "histological", "features", "of", "the", "inflamed", "synovial", "tissue", "C0003873#ent", "<e1>", "but", "also", "in", "some", "other", "forms", "of", "C0263680#ent", "<e2>", "is", "the", "presence", "of", "lymphocytes", "and", "plasma", "cells"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0263680", "name": "C0263680#ent", "pos": [20, 21]}}
{"token": ["Rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "is", "the", "dominant", "form", "of", "destructive", "C0263680#ent", "<e2>", "the", "potential", "to", "cause", "substantial", "disability", "permanent", "functional", "impairment"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0263680", "name": "C0263680#ent", "pos": [11, 12]}}
{"token": ["All", "157", "patients", "had", "symptoms", "of", "C0017168#ent", "<e1>", "endoscopically", "confirmed", "oesophageal", "erosions", "C2827459#ent", "<e2>", "and", "Miller", "grades", "I-III", ")", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2827459", "name": "C2827459#ent", "pos": [12, 13]}}
{"token": ["(", "1", ")", "C0663645#ent", "<e1>", ",", "first", "in", "a", "new", "class", "of", "cardiovascular", "drugs", "C0033607#ent", "<e2>", "is", "under", "evaluation", "for", "the", "management", "of", "hypertension", "and", "heart", "failure"], "h": {"id": "C0663645", "name": "C0663645#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [14, 15]}}
{"token": ["C0663645#ent", "<e1>", "and", "other", "C0033607#ent", "<e2>", "potential", "applications", "in", "the", "treatment", "of", "hypertension", ",", "heart", "failure", "and", "other", "cardiac", "and", "vascular", "disorders"], "h": {"id": "C0663645", "name": "C0663645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [4, 5]}}
{"token": ["C0663645#ent", "<e1>", "belongs", "to", "the", "C0033607#ent", "<e2>", "ie", ",", "drugs", "that", "possess", "the", "ability", "to", "inhibit", "simultaneously", "the", "membrane-bound", "zinc", "metalloproteases", "angiotensin-converting", "enzyme", "ACE", ")", ",", "and", "the", "neutral", "endopeptidase", "EC", "3.4.24.11", "NEP", ")", "."], "h": {"id": "C0663645", "name": "C0663645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [5, 6]}}
{"token": ["TNF", "alpha", "messenger", "RNA", "expression", "induced", "by", "C0175697#ent", "<e1>", "was", "inhibited", "by", "C0163305#ent", "<e2>", "MG132", ",", "and", "SB203580", ",", "but", "not", "by", "PD98059", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0163305", "name": "C0163305#ent", "pos": [12, 13]}}
{"token": ["Our", "data", "confirm", "that", "C0028968#ent", "<e1>", "OPCA", ")", "is", "the", "typical", "pattern", "in", "C0752121#ent", "<e2>", "."], "h": {"id": "C0028968", "name": "C0028968#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [13, 14]}}
{"token": ["The", "degeneration", "of", "the", "olivopontocerebellar", "regions", "in", "classical", "C0028968#ent", "<e1>", "early", "and", "severely", "in", "C0752121#ent", "<e2>", "."], "h": {"id": "C0028968", "name": "C0028968#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [14, 15]}}
{"token": ["We", "have", "identified", "a", "T3", "response", "element", "C1421114#ent", "<e1>", ")", "in", "the", "mouse", "C2985443#ent", "<e2>", "promoter", "between", "nucleotide", "positions", "and", "-309", "(", "5", "'", "CTGAGGTCAGTACAGGCTGGAGGAGTAGA", "3", "'", ")", "."], "h": {"id": "C1421114", "name": "C1421114#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2985443", "name": "C2985443#ent", "pos": [13, 14]}}
{"token": ["C0393534#ent", "<e1>", "PCD", ")", "is", "a", "debilitating", "C4020854#ent", "<e2>", "associated", "with", "antibodies", "directed", "against", "the", "purkinje", "cells", "the", "cerebellum", "."], "h": {"id": "C0393534", "name": "C0393534#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4020854", "name": "C4020854#ent", "pos": [7, 8]}}
{"token": ["It", "has", "been", "shown", "that", "C1423703#ent", "<e1>", "increases", "expression", "of", "some", "target", "C0017337#ent", "<e2>", "and", "we", "tested", "its", "effect", "on", "arginase", "induction", "."], "h": {"id": "C1423703", "name": "C1423703#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["As(3", "+", ")", "(", "1", "-", "25", "micro", "M", "increased", "mRNA", "levels", "of", "antioxidant", "C0014442#ent", "<e1>", "such", "as", "C0538674#ent", "<e2>", "HO-1", ")", ",", "thioredoxin", "peroxidase", "2", "NADPH", "dehydrogenase", "and", "glutathione", "S-transferase", "P", "subunit"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0538674", "name": "C0538674#ent", "pos": [18, 19]}}
{"token": ["Chat", "(", "C1335818#ent", "<e1>", "is", "a", "novel", "C1332163#ent", "<e2>", "an", "N-terminal", "Src", "homology-2", "domain", "C-terminal", "Cas/HEF1", "association", "domain", "."], "h": {"id": "C1335818", "name": "C1335818#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332163", "name": "C1332163#ent", "pos": [7, 8]}}
{"token": ["We", "examined", "the", "role", "of", "C0623362#ent", "<e1>", "in", "functions", "of", "C1420259#ent", "<e2>", "related", "to", "airway", "remodeling", "and", "found", "migration", "and", "proliferation", "were", "MMP", "dependent", ",", "whereas", "adhesion", "and", "apoptosis", "were", "not", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420259", "name": "C1420259#ent", "pos": [10, 11]}}
{"token": ["C1516119#ent", "<e1>", ",", "an", "inhibitor", "of", "C0033681#ent", "<e2>", "vascular", "endothelial", "growth", "factor", "receptor", "Raf/mitogen-activated", "protein", "kinase", "increases", "progression-free", "survival", "metastatic", "renal", "cell", "carcinoma", "RCC", ")", "compared", "with", "placebo", "."], "h": {"id": "C1516119", "name": "C1516119#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [6, 7]}}
{"token": ["From", "its", "susceptibility", "to", "known", "modifers", "of", "C3540759#ent", "<e1>", "it", "appears", "to", "be", "a", "C0072402#ent", "<e2>", "a", "trypsin-like", "nature"], "h": {"id": "C3540759", "name": "C3540759#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [14, 15]}}
{"token": ["The", "GPO", "activities", "of", "lines", "were", "not", "dependent", "upon", "the", "activities", "of", "the", "lipogenic", "enzyme", ",", "C0017875#ent", "<e1>", "the", "major", "ethanol-degrading", "enzyme", ",", "alcohol", "dehydrogenase", "or", "the", "citric", "acid", "cycle", "enzyme", "C0016799#ent", "<e2>", "."], "h": {"id": "C0017875", "name": "C0017875#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0016799", "name": "C0016799#ent", "pos": [31, 32]}}
{"token": ["The", "C0027120#ent", "<e1>", "of", "the", "C0225326#ent", "<e2>", "bundles", "was", "determined", "by", "urea", "gel", "electrophoresis", "was", "found", "to", "be", "approximately", "2", "light", "chains", "myosin", "molecule", "."], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [5, 6]}}
{"token": ["The", "most", "common", "causes", "are", "C0025517#ent", "<e1>", "connective", "tissue", "disorders", "neuropathic", "drug", "related", "injuries", ",", "paraneoplasic", "and", "post-infectious", "syndromes", "C0002726#ent", "<e2>", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [19, 20]}}
{"token": ["Extension", "of", "C0152252#ent", "<e1>", "recorded", "in", "nine", "C0235267#ent", "<e2>", "."], "h": {"id": "C0152252", "name": "C0152252#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [7, 8]}}
{"token": ["Similarly", ",", "fewer", "C0152252#ent", "<e1>", "observed", "in", "C0235267#ent", "<e2>", "implanted", "with", "surface", "modified", "IOLs", "in", "the", "posterior", "chamber", "in", "C0235267#ent", "<e2>", "implanted", "with", "control", "lenses"], "h": {"id": "C0152252", "name": "C0152252#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [7, 8]}}
{"token": ["To", "clarify", "the", "effect", "of", "bucillamine", ",", "an", "antirheumatic", "drug", "to", "C0030817#ent", "<e1>", ",", "on", "the", "development", "of", "human", "C1423842#ent", "<e2>", "and", "Th2", "cells", "in", "vitro"], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "identify", "C2986638#ent", "<e1>", "a", "direct", "target", "of", "PD-dependent", "C1709387#ent", "<e2>", "activation", "pathway", "in", "vitro", "in", "vivo"], "h": {"id": "C2986638", "name": "C2986638#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709387", "name": "C1709387#ent", "pos": [11, 12]}}
{"token": ["The", "results", "provide", "further", "evidence", "for", "the", "possible", "effectiveness", "of", "short", "courses", "of", "high", "dose", "corticosteroids", "in", "the", "treatment", "of", "relapses", "of", "C1417325#ent", "<e1>", "the", "usefulness", "of", "C1707163#ent", "<e2>", "in", "its", "assessment", "."], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1707163", "name": "C1707163#ent", "pos": [27, 28]}}
{"token": ["A", "51-year-old", "woman", "who", "had", "systemic", "Weber-Christian", "disease", "WCD", ")", "displayed", "multiple", "C0302314#ent", "<e1>", "lesions", "and", "a", "large", "C1275339#ent", "<e2>", "of", "the", "tentorium", "cerebelli", "signs", "of", "brainstem", "and", "cerebellar", "compression"], "h": {"id": "C0302314", "name": "C0302314#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1275339", "name": "C1275339#ent", "pos": [18, 19]}}
{"token": ["They", "have", "been", "called", "C0302314#ent", "<e1>", ",", "histiocytomas", ",", "solitary", "mast", "cell", "granulomas", "and", "C1275339#ent", "<e2>", "by", "various", "authors", "."], "h": {"id": "C0302314", "name": "C0302314#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1275339", "name": "C1275339#ent", "pos": [14, 15]}}
{"token": ["Immunohistochemical", "analysis", "SDS", "gel", "electrophoresis", "that", "almost", "half", "of", "the", "2B", "fibres", "C1447747#ent", "<e1>", "muscles", "expressed", "the", "2x/d", "C1417537#ent", "<e2>", "isoform", "."], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417537", "name": "C1417537#ent", "pos": [18, 19]}}
{"token": ["Although", "the", "enzyme", "deficiency", "known", "to", "be", "caused", "by", "C3538784#ent", "<e1>", "human", "diffuse", "histiocytic", "lymphoma", "cell", "line", "DHL-9", "any", "detectable", "C1417407#ent", "<e2>", "activity", "has", "been", "found", "to", "possess", "the", "intact", "MTAP", "gene"], "h": {"id": "C3538784", "name": "C3538784#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417407", "name": "C1417407#ent", "pos": [20, 21]}}
{"token": ["Alpha-Adrenergic", "blockers", "phentolamine", "and", "C0031441#ent", "<e1>", ",", "effectively", "prevented", "the", "increased", "C0014442#ent", "<e2>", "activities", "caused", "by", "administration", "of", "reserpine", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["To", "circumvent", "this", ",", "we", "have", "devised", "a", "simple", "PCR", "strategy", "involving", "targeting", "of", "the", "gene", "encoding", "the", "RNA", "polymerase", "beta", "subunit", "C0031441#ent", "<e1>", ")", ",", "a", "highly", "conserved", "C0014442#ent", "<e2>", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [29, 30]}}
{"token": ["All", "of", "eight", "homosexual", "men", "with", "generalized", "lymphadenopathy", "the", "C0001857#ent", "<e1>", "five", "homosexual", "men", "with", "AIDS", "C0240805#ent", "<e2>", "who", "subsequently", "had", "AIDS", "were", "also", "seropositive", "."], "h": {"id": "C0001857", "name": "C0001857#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0240805", "name": "C0240805#ent", "pos": [16, 17]}}
{"token": ["Familial", "Partial", "Lipodystrophy", "Dunnigan", "type", "(", "C1720861#ent", "<e1>", ")", ",", "is", "characterised", "by", "loss", "of", "subcutaneous", "fat", "the", "C0030196#ent", "<e2>", "and", "an", "excessive", "accumulation", "of", "fat", "on", "the", "neck", ",", "shoulder", "girdle", "face", "."], "h": {"id": "C1720861", "name": "C1720861#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [18, 19]}}
{"token": ["The", "therapeutic", "responses", "panic", "disorder", "TCA", "and", "C0026457#ent", "<e1>", "and", "the", "response", "to", "the", "chronic", "anxiety", "state", "C4048284#ent", "<e2>", "supports", "the", "classification", "ot", "two", "distinct", "syndromes", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [17, 18]}}
{"token": ["For", "social", "phobia", "SSRIs", "are", "recommended", "for", "the", "first", "line", ",", "and", "C0026457#ent", "<e1>", ",", "moclobemide", "and", "C4048284#ent", "<e2>", "as", "second", "line", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [17, 18]}}
{"token": ["Hallervorden-Spatz", "syndrome", "HSS", ")", "is", "a", "rare", "C3899988#ent", "<e1>", "clinically", "characterized", "by", "C0234133#ent", "<e2>", "progressive", "dementia", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [12, 13]}}
{"token": ["L-2-Hydroxyglutaric", "aciduria", "L-2-HGA", ",", "MIM", "236792", ")", "is", "a", "rare", "C3899988#ent", "<e1>", "neurodegenerative", "disorder", "by", "psychomotor", "delay", "cerebellar", "and", "C0234133#ent", "<e2>", "subcortical", "leukoencephalopathy", "basal", "ganglia", "dentate", "nuclei", "involvement", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [19, 20]}}
{"token": ["The", "action", "of", "AGF", "on", "glucose", "production", "inhibited", "by", "pretreatment", "of", "the", "cells", "with", "LY294002", "[", "C0950895#ent", "<e1>", "]", ",", "a", "phosphoinositide", "3-kinase", "PI3K", "inhibitor", ",", "and", "C0812228#ent", "<e2>", "(", "protein", "kinase", "B", "inhibitors", "."], "h": {"id": "C0950895", "name": "C0950895#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [27, 28]}}
{"token": ["Nausea", ",", "C0027769#ent", "<e1>", ",", "insomnia", ",", "and", "C0270697#ent", "<e2>", "are", "the", "most", "common", "side", "effects"], "h": {"id": "C0027769", "name": "C0027769#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [8, 9]}}
{"token": ["The", "ability", "of", "exogenously", "applied", "C3541396#ent", "<e1>", "to", "depress", "C1414919#ent", "<e2>", "in", "dentate", "granule", "cells", "on", "removal", "of", "polyvalent", "anions", "the", "superfusion", "medium"], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414919", "name": "C1414919#ent", "pos": [9, 10]}}
{"token": ["Uncommon", "causes", "of", "mitral", "incompetence", "may", "require", "valve", "replacement", "C0014117#ent", "<e1>", "Marfan's", "syndrome", "calcified", "mitral", "anulus", "osteogenesis", "imperfecta", "methysergide-induced", "heart", "disease", "and", "C0018799#ent", "<e2>"], "h": {"id": "C0014117", "name": "C0014117#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [22, 23]}}
{"token": ["The", "presence", "and", "distribution", "of", "human", "atrial", "natriuretic", "polypeptide", "ANP", ")", "were", "investigated", "immunohistochemically", "in", "the", "ventricles", "of", "hearts", "of", "14", "cases", "with", "C0014117#ent", "<e1>", "15", "cases", "with", "C0018799#ent", "<e2>", "children", "."], "h": {"id": "C0014117", "name": "C0014117#ent", "pos": [23, 24]}, "relation": "has_nichd_parent", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [28, 29]}}
{"token": ["C0014117#ent", "<e1>", "is", "a", "rare", "C0018799#ent", "<e2>", "poor", "prognosis", "uncertain", "cause", "."], "h": {"id": "C0014117", "name": "C0014117#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [5, 6]}}
{"token": ["Postulated", "and", "confirmed", "in", "animal", "experimental", "studies", "cardioprotective", "features", "C0061323#ent", "<e1>", "were", "evaluated", "in", "a", "randomised", ",", "placebo-controlled", "study", "C0061323#ent", "<e1>", "and", "glibenclamide", "comparing", "effects", "of", "drugs", "on", "ischaemic", "preconditioning", "angioplasty", "of", "C0242231#ent", "<e1>", "patients", "with", "stable", "angina"], "h": {"id": "C0061323", "name": "C0061323#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242231", "name": "C0242231#ent", "pos": [32, 33]}}
{"token": ["Activated", "forms", "of", "microglia", "were", "ultrastructurally", "evaluated", "in", "three", "C0042075#ent", "<e1>", "different", "aetiology", "(", "subacute", "sclerosing", "panencephalitis", "SSPE", ",", "C0019202#ent", "<e2>", "Alzheimer's", "disease", "."], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [19, 20]}}
{"token": ["Repetitive", "speech", "phenomena", "morphologically", "heterogeneous", "iterations", "of", "speech", "which", "have", "been", "described", "in", "several", "C0042075#ent", "<e1>", "as", "vascular", "dementia", "progressive", "supranuclear", "palsy", "C0019202#ent", "<e2>", "and", "Parkinson's", "disease", "and", "which", "are", "presently", "only", "poorly", "understood", "."], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [22, 23]}}
{"token": ["Other", "diseases", "occurring", "with", "C0042075#ent", "<e1>", "conjunctivitis", ",", "dermatitis/stomatitis", ",", "pneumonia", "and", "C0019202#ent", "<e2>"], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [12, 13]}}
{"token": ["Although", "spinal", "disorders", "been", "recognized", "for", "a", "long", "time", "the", "view", "of", "C0026256#ent", "<e1>", "as", "a", "particular", "C0029896#ent", "<e2>", "a", "more", "recent", "development", "."], "h": {"id": "C0026256", "name": "C0026256#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}}
{"token": ["A", "double-blind", ",", "randomized", "study", "designed", "to", "compare", "the", "recovery", "manner", "of", "C0066621#ent", "<e1>", "infusion", "with", "or", "without", "C0013617#ent", "<e2>", "reversal", "in", "microscopic", "laryngeal", "surgery"], "h": {"id": "C0066621", "name": "C0066621#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013617", "name": "C0013617#ent", "pos": [18, 19]}}
{"token": ["Two", "ATP-dependent", "C2717814#ent", "<e1>", "mitochondrial", "import", "stimulation", "factor", "MSF", ")", "and", "C1415760#ent", "<e2>", ",", "are", "known", "to", "be", "involved", "in", "the", "import", "of", "precursor", "proteins", "mitochondria", "."], "h": {"id": "C2717814", "name": "C2717814#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [11, 12]}}
{"token": ["C3536983#ent", "<e1>", "HYP", ")", ",", "the", "most", "common", "form", "of", "C0020631#ent", "<e2>", "vitamin", "D-resistant", "rickets", ",", "is", "an", "X-linked", "dominant", "disorder", "by", "decreased", "renal", "tubular", "phosphate", "reabsorption", "consequent", "hypophosphatemia", "."], "h": {"id": "C3536983", "name": "C3536983#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020631", "name": "C0020631#ent", "pos": [10, 11]}}
{"token": ["Immunochemical", "analyses", "revealed", "that", "the", "enhancement", "of", "C0017375#ent", "<e1>", "activity", "in", "ethanol-fed", "rats", "correlated", "with", "an", "increase", "in", "C0002484#ent", "<e2>"], "h": {"id": "C0017375", "name": "C0017375#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002484", "name": "C0002484#ent", "pos": [18, 19]}}
{"token": ["There", "was", "no", "long-term", "objective", "benefit", "from", "C0596537#ent", "<e1>", "treatment", "in", "C1413603#ent", "<e2>", "patients", "."], "h": {"id": "C0596537", "name": "C0596537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413603", "name": "C1413603#ent", "pos": [11, 12]}}
{"token": ["ET-1", "levels", "are", "increased", "in", "plasma", "and", "synovial", "membrane", "C0003873#ent", "<e1>", "RA", ")", "patients", ",", "but", "the", "evidence", "that", "C1705691#ent", "<e2>", "participate", "in", "RA", "physiopathology", "is", "limited", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705691", "name": "C1705691#ent", "pos": [19, 20]}}
{"token": ["Rather", ",", "C0003873#ent", "<e1>", "responsiveness", "of", "the", "CD18", "proximal", "promoter", "requires", "C1705691#ent", "<e2>", "are", "bound", "by", "GA-binding", "protein", "GABP", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705691", "name": "C1705691#ent", "pos": [11, 12]}}
{"token": ["We", "have", "identified", "C3540628#ent", "<e1>", "as", "a", "new", "C0017337#ent", "<e2>", "that", "increases", "in", "expression", "in", "sympathetic", "neurons", "NGF", "withdrawal", "."], "h": {"id": "C3540628", "name": "C3540628#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["However", ",", "TGF-beta", "has", "no", "effect", "the", "expression", "of", "other", "C1417123#ent", "<e1>", ",", "such", "as", "fos", "and", "C0079471#ent", "<e2>", "."], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [17, 18]}}
{"token": ["The", "activated", "ras", "C1417123#ent", "<e1>", "that", "is", "present", "in", "C0079471#ent", "<e2>", "able", "to", "induce", "malignant", "transformation", "of", "pure", "cultures", "of", "mouse", "primary", "keratinocytes", "."], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [9, 10]}}
{"token": ["The", "R.", "marmoratus", "C1384510#ent", "<e1>", "of", "1763", "bp", "encoding", "375", "C3539946#ent", "<e2>", "5", "exons", "and", "4", "introns", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [10, 11]}}
{"token": ["The", "C1384510#ent", "<e1>", "a", "predicted", "open", "reading", "frame", "of", "373", "C3539946#ent", "<e2>", "that", "was", "found", "to", "have", "high", "homology", "(", "99.2", "-", "99.7", "%", "identical", ")", "with", "several", "other", "species", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [10, 11]}}
{"token": ["Human", "FGF8", "C0597298#ent", "<e1>", "90.6", "%", "total-amino-acid", "identity", "with", "rat", "C1333539#ent", "<e2>", "(", "268", "aa", ")", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333539", "name": "C1333539#ent", "pos": [10, 11]}}
{"token": ["Maze", "tests", "were", "used", "to", "determine", "the", "effects", "on", "cognition", "of", "conventional", "dopamine", "antagonist", "neuroleptics", "haloperidol", "and", "C0016368#ent", "<e1>", ")", "and", "the", "newer", "serotonin-dopamine", "antagonist", "antipsychotics", "(", "C0073393#ent", "<e2>", "and", "clozapine", ")", "."], "h": {"id": "C0016368", "name": "C0016368#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [27, 28]}}
{"token": ["These", "were", "haloperidol", ",", "C0016368#ent", "<e1>", ",", "clopenthixol", ",", "melperone", ",", "tefludazine", ",", "setoperone", ",", "C0073393#ent", "<e2>", ",", "and", "clozapine", "."], "h": {"id": "C0016368", "name": "C0016368#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [15, 16]}}
{"token": ["The", "nda1", "+", "and", "nda4", "+", "C0017337#ent", "<e1>", "of", "the", "fission", "yeast", "Schizosaccharomyces", "pombe", "proteins", "similar", "to", "budding", "yeast", "C1334489#ent", "<e2>", "and", "MCM5/CDC46", ",", "respectively", ",", "which", "are", "required", "for", "the", "early", "stages", "DNA", "replication"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334489", "name": "C1334489#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "suggest", "that", "hypomorphic", "alleles", "of", "the", "C0017337#ent", "<e1>", "encoding", "the", "subunits", "of", "the", "C1334489#ent", "<e2>", "-", "7", "complex", "may", "increase", "breast", "cancer", "risk", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334489", "name": "C1334489#ent", "pos": [15, 16]}}
{"token": ["The", "association", "of", "C1282971#ent", "<e1>", "vWD", ")", "with", "C1861185#ent", "<e2>", "spontaneous", "platelet", "aggregation", "recently", "been", "recognized", "."], "h": {"id": "C1282971", "name": "C1282971#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1861185", "name": "C1861185#ent", "pos": [8, 9]}}
{"token": ["The", "results", "indicate", "that", "lack", "of", "insulin", "action", "an", "anticoordinate", "change", "in", "gastrointestinal", "lipolytic", "enzymes", ",", "with", "decreases", "in", "pancreatic", "carboxyl", "ester", "lipase", "C0031667#ent", "<e1>", "and", "lingual", "lipase", "contents", "and", "an", "increase", "in", "C0443469#ent", "<e2>", "content", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0443469", "name": "C0443469#ent", "pos": [33, 34]}}
{"token": ["The", "newly", "observed", "radiological", "feature", "of", "the", "acromegalic", ",", "hyperostosis", "of", "the", "spinous", "processes", "believed", "to", "contribute", "to", "the", "C0003862#ent", "<e1>", "in", "the", "C0024031#ent", "<e2>"], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [23, 24]}}
{"token": ["The", "major", "features", "on", "presentation", ",", "irrespective", "of", "the", "course", "of", "the", "disease", ",", "were", "fever", ",", "sweating", ",", "headache", ",", "rigors", ",", "C0003862#ent", "<e1>", ",", "myalgia", ",", "and", "C0024031#ent", "<e2>"], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [29, 30]}}
{"token": ["Recently", "two", "larger", "trials", "(", "SURVIVE", "and", "C0310031#ent", "<e1>", ")", "in", "patients", "who", "were", "hospitalized", "because", "of", "worsening", "C0018802#ent", "<e2>", "been", "finalized", "."], "h": {"id": "C0310031", "name": "C0310031#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [18, 19]}}
{"token": ["Statistical", "analysis", "the", "distinct", "C1706005#ent", "<e1>", ",", "IgA", ",", "and", "C1367597#ent", "<e2>", "levels", "showed", "no", "significant", "correlation", "with", "either", "birth", "weight", "birth", "length"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367597", "name": "C1367597#ent", "pos": [10, 11]}}
{"token": ["Geometric", "mean", "levels", "5.58", "mg/l", "for", "IgA", ",", "142", "mg/l", "for", "C1706005#ent", "<e1>", "and", "53.6", "mg/l", "for", "C1367597#ent", "<e2>", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1367597", "name": "C1367597#ent", "pos": [17, 18]}}
{"token": ["IL-8", "increased", "DNA", "synthesis", "Caco2", "in", "a", "dose", "dependent", "manner", "and", "this", "was", "inhibited", "by", "C1314771#ent", "<e1>", ",", "EGFR", "kinase", ",", "and", "C2347168#ent", "<e2>"], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2347168", "name": "C2347168#ent", "pos": [22, 23]}}
{"token": ["Four", "patients", "developed", "immune", "disorders", "3", "cases", "of", "C0035436#ent", "<e1>", "rheumatoid", "polyarthritis-like", "diseases", "and", "1", "case", "of", "C1426204#ent", "<e2>"], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1426204", "name": "C1426204#ent", "pos": [17, 18]}}
{"token": ["Although", "C0030310#ent", "<e1>", "has", "fewest", "side", "effects", "to", "other", "currently", "used", "C0010464#ent", "<e2>", "it", "is", "still", "not", "the", "ideal", "relaxant", "."], "h": {"id": "C0030310", "name": "C0030310#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010464", "name": "C0010464#ent", "pos": [11, 12]}}
{"token": ["Additionally", ",", "LAQ824", "down-regulated", "the", "levels", "of", "mutant", "C1835417#ent", "<e1>", "possessing", "the", "C4085851#ent", "<e2>", "as", "well", "as", "induced", "apoptosis", "of", "imatinib-refractory", "primary", "cells", "."], "h": {"id": "C1835417", "name": "C1835417#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4085851", "name": "C4085851#ent", "pos": [12, 13]}}
{"token": ["C1417708#ent", "<e1>", "activation", "of", "the", "C1706585#ent", "<e2>", "promoter", "then", "leads", "to", "a", "stepwise", "increase", "in", "C1706585#ent", "<e2>", "transcription", ",", "expression", "and", "activity", ",", "and", "MLCK-mediated", "opening", "of", "the", "intestinal", "TJ", "barrier", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706585", "name": "C1706585#ent", "pos": [5, 6]}}
{"token": ["The", "TNF-alpha-induced", "increase", "in", "MLCK", "promoter", "activity", "mediated", "by", "C1417708#ent", "<e1>", "and", "the", "inhibition", "of", "C1417708#ent", "<e1>", "the", "TNF-alpha-induced", "increase", "in", "promoter", "activity", "the", "subsequent", "increase", "in", "C1706585#ent", "<e1>", "expression", "and", "Caco-2", "TJ", "permeability", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706585", "name": "C1706585#ent", "pos": [27, 28]}}
{"token": ["C0909712#ent", "<e1>", "NdK", ")", "is", "a", "ubiquitous", "C0027203#ent", "<e2>", "in", "both", "prokaryotes", "and", "eukaryotes", "and", "is", "primarily", "involved", "in", "the", "maintenance", "of", "cellular", "nucleotide", "pools", "."], "h": {"id": "C0909712", "name": "C0909712#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}}
{"token": ["C0083632#ent", "<e1>", "reduced", "the", "IL-6", "synthesis", "induced", "by", "cholera", "toxin", "C0917964#ent", "<e2>", "or", "dibutyryl", "cAMP", "."], "h": {"id": "C0083632", "name": "C0083632#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [10, 11]}}
{"token": ["This", "was", "associated", "with", "higher", "level", "of", "C1710520#ent", "<e1>", "and", "2.7-fold", "higher", "levels", "of", "IRCT", "as", "compared", "to", "C0003838#ent", "<e2>"], "h": {"id": "C1710520", "name": "C1710520#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003838", "name": "C0003838#ent", "pos": [18, 19]}}
{"token": ["C0025303#ent", "<e1>", "one", "of", "the", "very", "few", "severe", "C0004623#ent", "<e2>", "in", "this", "era", ",", "that", "still", "can", "kill", "a", "relatively", "healthy", "child", "minutes", "."], "h": {"id": "C0025303", "name": "C0025303#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [8, 9]}}
{"token": ["Four", "were", "intubated", "with", "C0022614#ent", "<e1>", "and", "succinylcholine", "and", "mechanically", "ventilated", "immediate", "improvement", "of", "C0268047#ent", "<e2>"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268047", "name": "C0268047#ent", "pos": [14, 15]}}
{"token": ["Salient", "features", "of", "multiple", "dosing", "diazepam", "and", "C0022614#ent", "<e1>", "were", "hypoventilation", ",", "C0268047#ent", "<e2>", "an", "increase", "in", "both", "systemic", "and", "pulmonary", "vascular", "resistance"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268047", "name": "C0268047#ent", "pos": [12, 13]}}
{"token": ["Standard", "therapy", "oral", "calcium", "supplements", "C4020599#ent", "<e1>", "and", "vitamin", "D", "preparations", "is", "often", "inadequate", "to", "control", "progressive", "C0005940#ent", "<e2>"], "h": {"id": "C4020599", "name": "C4020599#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "C1366763#ent", "<e1>", "enriched", "the", "130-bp", "proximal", "C1416945#ent", "<e2>", "promoter", "in", "chromatin", "immunoprecipitation", "analyses"], "h": {"id": "C1366763", "name": "C1366763#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416945", "name": "C1416945#ent", "pos": [8, 9]}}
{"token": ["C0243025#ent", "<e1>", "HPS", ")", "is", "an", "acute", "viral", "rodentborne", "C0043528#ent", "<e2>", "characterized", "by", "severe", "cardiopulmonary", "illness", "a", "40%-60", "%", "case-fatality", "rate", "."], "h": {"id": "C0243025", "name": "C0243025#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [9, 10]}}
{"token": ["C0028866#ent", "<e1>", "often", "III-nerve", ")", "and", "C0029132#ent", "<e2>", "also", "occur", "."], "h": {"id": "C0028866", "name": "C0028866#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029132", "name": "C0029132#ent", "pos": [6, 7]}}
{"token": ["Genetic", "differences", "found", "in", "rice", "for", "the", "root", "elongation", "C0017925#ent", "<e1>", "REP", ")", ",", "for", "which", "a", "distinct", "C0597336#ent", "<e2>", "QTL", ")", "was", "detected", "on", "the", "long", "arm", "of", "6", "."], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0597336", "name": "C0597336#ent", "pos": [18, 19]}}
{"token": ["Sphingosylphosphorylcholine", "(", "C1442758#ent", "<e1>", ")", "is", "an", "important", "lipid", "mediator", "has", "been", "implicated", "in", "C0268790#ent", "<e2>"], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [14, 15]}}
{"token": ["C0012544#ent", "<e1>", "seem", "to", "act", "in", "C0035435#ent", "<e2>", "reducing", "bone", "turnover", "of", "improving", "disease", "activity"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [6, 7]}}
{"token": ["A", "30-year-old", "male", "with", "C0013080#ent", "<e1>", "from", "a", "C0007785#ent", "<e2>", "died", "of", "brain", "herniation"], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [8, 9]}}
{"token": ["In", "this", "report", ",", "we", "describe", "a", "C0013080#ent", "<e1>", "patient", "with", "MALT", "thyroid", "lymphoma", "C0007785#ent", "<e2>"], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [14, 15]}}
{"token": ["In", "summary", ",", "the", "three", "C3541957#ent", "<e1>", "and", "isoxazolidinedione", "act", "differently", "on", "C0001477#ent", "<e2>", "K(+", ")", "channels", "in", "vascular", "smooth", "muscle"], "h": {"id": "C3541957", "name": "C3541957#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "whether", "C0286651#ent", "<e1>", "can", "prevent", "the", "neurodegeneration", "induced", "by", "a", "mitochondrial", "toxin", "C0047640#ent", "<e2>", "3NP", ")", ",", "which", "inhibits", "succinate", "dehydrogenase", "complex", "II"], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0047640", "name": "C0047640#ent", "pos": [14, 15]}}
{"token": ["C0011854#ent", "<e1>", "has", "been", "classified", "by", "C1412179#ent", "<e2>", "as", "idiopathic", "Type", "1", "diabetes", "Type", "1b", "the", "most", "common", "atypical", "form"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [6, 7]}}
{"token": ["Off-pump", "coronary", "artery", "bypass", "C3811222#ent", "<e1>", ")", "using", "the", "left", "internal", "thoracic", "artery", "LITA", ")", "with", "a", "composite", "radial", "artery", "C0003873#ent", "<e2>", ")", "was", "employed", "for", "arterial", "revascularization", "order", "to", "minimize", "neurological", "complication"], "h": {"id": "C3811222", "name": "C3811222#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [20, 21]}}
{"token": ["We", "showed", "in", "this", "study", "that", "cells", "deficient", "of", "the", "BRCA1-associated", "C1426958#ent", "<e1>", "also", "known", "as", "C1880731#ent", "<e2>", ",", "failed", "to", "elicit", "homologous", "recombination", "HR", ")", "after", "DNA", "double-stranded", "breaks", "DSBs", ")", "."], "h": {"id": "C1426958", "name": "C1426958#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1880731", "name": "C1880731#ent", "pos": [16, 17]}}
{"token": ["C1426958#ent", "<e1>", "(", "also", "known", "as", "FANCJ", "and", "C1880731#ent", "<e2>", ")", "is", "a", "DNA", "helicase", "directly", "interacts", "with", "the", "C-terminal", "BRCT", "of", "the", "breast", "cancer", "susceptibility", "protein", "BRCA1", "."], "h": {"id": "C1426958", "name": "C1426958#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1880731", "name": "C1880731#ent", "pos": [8, 9]}}
{"token": ["Suggestive", "C0037285#ent", "<e1>", "namely", "palmoplantar", "pustulosis", "severe", "C0001144#ent", "<e2>", ",", "generally", "antedate", "the", "bone", "and", "joint", "lesions"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001144", "name": "C0001144#ent", "pos": [7, 8]}}
{"token": ["Deletions", "of", "these", "sequences", "by", "Bal3l", "nuclease", "in", "vitro", "genetic", "selection", "C3811772#ent", "<e1>", "incompatibility", "function", "in", "vivo", "isolation", "of", "a", "plasmid", "expressing", "C2987364#ent", "<e2>", "ColE1", "RNA1", "initiated", "properly", "from", "the", "S.", "marcesens", "trp", "promoter", "."], "h": {"id": "C3811772", "name": "C3811772#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "the", "level", "of", "the", "C3811772#ent", "<e1>", "transcript", "decreases", "more", "than", "15-fold", "in", "the", "absence", "of", "C2987364#ent", "<e2>", "Mga2p", "and", "Spt23p", "."], "h": {"id": "C3811772", "name": "C3811772#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [17, 18]}}
{"token": ["C0030899#ent", "<e1>", "has", "been", "reported", "to", "increase", "cerebral", "blood", "flow", "C1428360#ent", "<e2>", ")", "and", "improve", "recovery", "rate", "stroke", "patients", "."], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [10, 11]}}
{"token": ["C0030899#ent", "<e1>", "did", "not", "change", "C1428360#ent", "<e2>", "following", "topical", "application", "increased", "C1428360#ent", "<e2>", "slightly", "following", "systemic", "administration"], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [5, 6]}}
{"token": ["It", "was", "thus", "found", "that", "gizzard", "C0949646#ent", "<e1>", "and", "gizzard", "C1842796#ent", "<e2>", "behaved", "differently", "from", "skeletal", "myosin", "skeletal", "C1842796#ent", "<e2>", ",", "whereas", "gizzard", "actin", "in", "the", "same", "wasy", "as", "skeletal", "actin"], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1842796", "name": "C1842796#ent", "pos": [10, 11]}}
{"token": ["Actin", ",", "C0949646#ent", "<e1>", ",", "and", "\"", "native", "\"", "tropomyosin", "(", "C1842796#ent", "<e2>", ")", "were", "separately", "isolated", "from", "chicken", "gizzard", "muscle", "and", "rabbit", "skeletal", "muscle"], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1842796", "name": "C1842796#ent", "pos": [11, 12]}}
{"token": ["The", "relative", "potency", "for", "suppression", "of", "operant", "responding", "was", ":", "C0031381#ent", "<e1>", "=", "TCP", "greater", "than", "C3539770#ent", "<e2>", "greater", "than", "PCE", "greater", "than", "PCM", "greater", "than", "ketamine", "."], "h": {"id": "C0031381", "name": "C0031381#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539770", "name": "C3539770#ent", "pos": [16, 17]}}
{"token": ["In", "C0019069#ent", "<e1>", "plasma", ",", "purified", "Factor", "VIII", "associated", "with", "endogenous", "C1336938#ent", "<e2>", "resulting", "in", "a", "complete", "protection", "against", "APC", "(", "4", "nM", ")", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [1, 2]}, "relation": "disease_has_associated_gene", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [11, 12]}}
{"token": ["The", "principal", "objective", "of", "this", "study", "was", "to", "generate", "a", "lentivirus-based", "C1336938#ent", "<e1>", "expression", "vector", "for", "gene", "therapy", "C0019069#ent", "<e2>", "inserted", "a", "C1336938#ent", "<e1>", "of", "8.8", "Kb", "into", "a", "lentiviral", "vector", "producing", "VSV-G-pseudotyped", "vEx52", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [18, 19]}, "relation": "disease_has_associated_gene", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [11, 12]}}
{"token": ["Since", "gene", "therapy", "C0019069#ent", "<e1>", "ultimately", "target", "endothelium", "or", "hematopoietic", "stem", "cells", "the", "interaction", "between", "C1336938#ent", "<e2>", "and", "FVIII", "within", "a", "secretory", "cell", "important", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [15, 16]}}
{"token": ["Some", "patients", "report", "C0035455#ent", "<e1>", "symptoms", "after", "exposure", "to", "environmental", "tobacco", "smoke", "C0812380#ent", "<e2>", ")", ",", "but", "objective", "assessments", "of", "this", "response", "have", "been", "lacking", "."], "h": {"id": "C0035455", "name": "C0035455#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812380", "name": "C0812380#ent", "pos": [12, 13]}}
{"token": ["On", "the", "contrary", ",", "the", "TRH-induced", "stimulation", "of", "either", "C0694890#ent", "<e1>", "likely", "involves", "Ca(2+)-dependent", "mechanisms", "because", "C0243192#ent", "<e2>", "the", "peptide", "exert", "non-additive", "effects", "."], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [16, 17]}}
{"token": ["C-TAK1", "C0907533#ent", "<e1>", "associates", "with", "mammalian", "C1334325#ent", "<e2>", "and", "phosphorylates", "serine", "392", "to", "confer", "14", "-", "3", "-", "3", "binding", "and", "cytoplasmic", "sequestration", "C1334325#ent", "<e2>", "in", "unstimulated", "cells", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334325", "name": "C1334325#ent", "pos": [6, 7]}}
{"token": ["They", "have", "impaired", "secretion", "of", "FSH", "and", "C1538681#ent", "<e1>", "and", "a", "Leydig", "cell", "insensitivity", "to", "C3536870#ent", "<e2>", "."], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536870", "name": "C3536870#ent", "pos": [15, 16]}}
{"token": ["The", "incubation", "media", "were", "assayed", "for", "FSH", "and", "C1538681#ent", "<e1>", "and", "the", "results", "expressed", "as", "nanograms", "of", "C3536870#ent", "<e2>", "released", "per", "milligram", "HP", "."], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536870", "name": "C3536870#ent", "pos": [17, 18]}}
{"token": ["The", "relationship", "between", "ovarian", "steroids", "C1538681#ent", "<e1>", "during", "the", "midcycle", "C3536870#ent", "<e2>", "surge", "is", "controversial", "."], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536870", "name": "C3536870#ent", "pos": [10, 11]}}
{"token": ["We", "confirm", "that", "DNA", "pol", "gamma", "is", "an", "active", "C1413979#ent", "<e1>", "show", "that", "other", "members", "of", "the", "family", "A", "of", "C0012888#ent", "<e2>", "Escherichia", "coli", "DNA", "pol", "I", "possess", "this", "activity", "."], "h": {"id": "C1413979", "name": "C1413979#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012888", "name": "C0012888#ent", "pos": [20, 21]}}
{"token": ["Injection", "of", "streptozotocin", "induced", "glucosuria", ",", "C0475718#ent", "<e1>", ",", "hypoinsulinaemia", ",", "hypothyroidism", ",", "hypercholesterolaemia", ",", "C0020557#ent", "<e2>", ",", "bradycardia", "and", "a", "decrease", "in", "left", "ventricular", "developed", "pressure", "LVDP", ")", "."], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [15, 16]}}
{"token": ["The", "high", "prevalence", "and", "severity", "of", "metabolic", "disturbances", "associated", "with", "insulin", "resistance", "syndrome", "C0475718#ent", "<e1>", ",", "hyperinsulinaemia", ",", "decreased", "HDL", "cholesterol", "C0020557#ent", "<e2>", ",", "elevated", "fibrinogen", "levels", "hyperuricaemia", ")", "before", "gastroplasty", "were", "significantly", "decreased", "after", "weight", "loss"], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [21, 22]}}
{"token": ["The", "human", "DNA", "binding", "factor", "C3273319#ent", "<e1>", ",", "which", "associates", "with", "the", "promoter", "region", "the", "C1334899#ent", "<e2>", "hGR", "gene", ")", ",", "is", "a", "repressor", "of", "glucocorticoid", "receptor", "transcription"], "h": {"id": "C3273319", "name": "C3273319#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [15, 16]}}
{"token": ["The", "purified", "enzyme", "in", "the", "absence", "of", "C1413138#ent", "<e1>", "was", "stimulated", "by", "sodium", "nitroprusside", "N-methyl-N'-nitro-N-nitrosoguanidine", "and", "C0525082#ent", "<e2>", "and", "in", "the", "presence", "of", "C1413138#ent", "<e1>", "by", "sodium", "nitrite", "sodium", "azide"], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0525082", "name": "C0525082#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "mu", "C1825242#ent", "<e1>", "can", "not", "be", "derived", "from", "C1413112#ent", "<e2>", "by", "limited", "autolysis", "."], "h": {"id": "C1825242", "name": "C1825242#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413112", "name": "C1413112#ent", "pos": [10, 11]}}
{"token": ["The", "genomic", "response", "C1412228#ent", "<e1>", "involves", "at", "least", "73", "C1417679#ent", "<e2>", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}}
{"token": ["Most", "neuronal", "cysteine", "uptake", "is", "mediated", "by", "sodium-dependent", "excitatory", "C1420191#ent", "<e1>", "EAAT", ")", "systems", ",", "known", "as", "C1420119#ent", "<e2>", "EAAC1", ")", "."], "h": {"id": "C1420191", "name": "C1420191#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420119", "name": "C1420119#ent", "pos": [17, 18]}}
{"token": ["Neutral", "endopeptidase", "NEP", ")", "is", "a", "widely", "distributed", "C0014442#ent", "<e1>", "that", "participates", "in", "ANP", "catabolism", ",", "whereas", "cGMP-phosphodiesterase", "(", "C1849508#ent", "<e2>", ")", "degrades", "the", "intracellular", "second", "messenger", "of", "ANP", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1849508", "name": "C1849508#ent", "pos": [19, 20]}}
{"token": ["During", "percutaneous", "coronary", "interventions", "patients", "with", "C0011860#ent", "<e1>", "preferably", "treated", "with", "drug-eluting", "stent", "combination", "with", "C0070166#ent", "<e2>", ",", "and", "in", "case", "of", "an", "acute", "coronary", "syndrome", "glycoprotein", "(", "GP", ")", "IIb/IIIa", "receptor", "antagonists", "are", "added", "to", "the", "standard", "treatment"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0070166", "name": "C0070166#ent", "pos": [15, 16]}}
{"token": ["In", "the", "diabetic", "mouse", ",", "the", "C0384464#ent", "<e1>", "content", "of", "the", "C0268731#ent", "<e2>", "and", "tubular", "basement", "membranes", "increased", ",", "with", "marked", "expression", "in", "the", "mesangium", "."], "h": {"id": "C0384464", "name": "C0384464#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [11, 12]}}
{"token": ["Prior", "and", "ongoing", "use", "of", "narcotics", "and", "C0036557#ent", "<e1>", "acts", "to", "compound", "and", "aggravate", "the", "C1298685#ent", "<e2>"], "h": {"id": "C0036557", "name": "C0036557#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1298685", "name": "C1298685#ent", "pos": [15, 16]}}
{"token": ["The", "C0027203#ent", "<e1>", "activities", "for", "C1706902#ent", "<e2>", "(", "3-fold", ")", "and", "BaP", "(", "16-fold", ")", "metabolism", "were", "selectively", "induced", "by", "PB", "and", "3-MC", ",", "respectively", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706902", "name": "C1706902#ent", "pos": [5, 6]}}
{"token": ["We", "report", "a", "case", "of", "C0156147#ent", "<e1>", "associated", "with", "nephrotic", "syndrome", "to", "C1416945#ent", "<e2>", "a", "21-year-old", "man", "in", "whom", "remission", "of", "both", "C0156147#ent", "<e1>", "the", "nephrotic", "syndrome", "been", "maintained", "with", "an", "elemental", "diet"], "h": {"id": "C1416945", "name": "C1416945#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [5, 6]}}
{"token": ["Anti-C1q", "antibodies", "were", "found", "in", "60", "%", "of", "patients", "with", "C0024143#ent", "<e1>", "compared", "with", "only", "14", "%", "of", "SLE", "patients", "without", "C0022658#ent", "<e2>", "(", "P", "<", "0.05", ")", "."], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [21, 22]}}
{"token": ["ICs", "from", "patients", "with", "C0024143#ent", "<e1>", "more", "inhibitory", "than", "ICs", "from", "patients", "without", "C0022658#ent", "<e2>"], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [13, 14]}}
{"token": ["These", "data", "demonstrate", "a", "requirement", "for", "C1332722#ent", "<e1>", "in", "SPB", "duplication", "and", "suggest", "a", "role", "for", "this", "C0079429#ent", "<e2>", "in", "G1", "control"], "h": {"id": "C1332722", "name": "C1332722#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}}
{"token": ["PNS", "involvement", "was", "dominated", "by", "C0151313#ent", "<e1>", "carpal", "tunnel", "syndromes", "cranial", "nerve", "palsies", "above", "all", "C0152177#ent", "<e2>", "and", "pupillary", "dysfunction"], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0152177", "name": "C0152177#ent", "pos": [15, 16]}}
{"token": ["Administration", "of", "cortisone", ",", "heparin", ",", "or", "C0010206#ent", "<e1>", "did", "not", "prevent", "DIC", ",", "and", "xi-aminocaproic", "acid", "C0004057#ent", "<e2>", "or", "an", "onion-rich", "diet", "tended", "to", "increase", "its", "incidence", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [17, 18]}}
{"token": ["However", ",", "there", "has", "been", "no", "direct", "comparison", "with", "C0010206#ent", "<e1>", "or", "heparin", "to", "indicate", "that", "C0004057#ent", "<e2>", "is", "the", "optimal", "form", "of", "thromboprophylaxis", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [16, 17]}}
{"token": ["Stent", "placement", "was", "followed", "by", "anticoagulation", "therapy", "C0010206#ent", "<e1>", "combined", "with", "C0004057#ent", "<e2>"], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [11, 12]}}
{"token": ["A", "synthetic", "approach", "used", "to", "examine", "the", "contribution", "that", "the", "oscillatory", "potentials", "C2987131#ent", "<e1>", ")", "bring", "to", "the", "C2984892#ent", "<e2>", "of", "the", "electroretinogram", "."], "h": {"id": "C2987131", "name": "C2987131#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2984892", "name": "C2984892#ent", "pos": [18, 19]}}
{"token": ["At", "least", "two", "genetic", "mechanisms", "been", "proposed", "that", "play", "a", "role", "in", "susceptibility", "to", "C1290138#ent", "<e1>", "firstly", "the", "maintenance", "of", "immune", "tolerance", "C0017337#ent", "<e2>", "on", "the", "X", "chromosomes", ",", "secondly", ",", "fetal", "microchimerism", "."], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [22, 23]}}
{"token": ["A", "crucial", "component", "in", "C1290138#ent", "<e1>", "pathogenesis", "is", "the", "persistent", "and", "unregulated", "activation", "of", "C0017337#ent", "<e2>", "encoding", "the", "various", "extracellular", "matrix", "proteins"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "we", "have", "determined", "that", "C0128818#ent", "<e1>", "is", "recruited", "to", "the", "cortex", "at", "the", "site", "of", "C0080298#ent", "<e2>", "mRNA", "injection", "."], "h": {"id": "C0128818", "name": "C0128818#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", "we", "identify", "two", "actin", "binding", "proteins-cortactin", "C0128818#ent", "<e1>", "--", "as", "C0080298#ent", "<e2>", "substrates", "in", "Xenopus", "oocytes", "are", "C0080298#ent", "<e2>", "substrates", "."], "h": {"id": "C0128818", "name": "C0128818#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [13, 14]}}
{"token": ["Genistein", ",", "or", "the", "specific", "Src", "inhibitors", "PP-1", "and", "PP-2", "(", "1", "-", "10", "micrometer", ")", "inhibited", "H(2)O(2)-mediated", "C2987024#ent", "<e1>", "activation", "by", "45", "%", ",", "indicating", "that", "C0080298#ent", "<e2>", "contributes", "to", "this", "signaling", "pathway"], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [27, 28]}}
{"token": ["It", "was", "observed", "that", "C0038880#ent", "<e1>", "competed", "with", "heparin-Sepharose", "gel", "for", "binding", "to", "C4084825#ent", "<e2>", "and", "the", "inhibition", "of", "chymase", "activity", "C0038880#ent", "<e1>", "was", "partially", "impaired", "by", "heparin", "."], "h": {"id": "C0038880", "name": "C0038880#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4084825", "name": "C4084825#ent", "pos": [13, 14]}}
{"token": ["The", "neuroprotective", "effects", "GTS-21", "[", "3-(2,4-dimethoxybenzylidene)-anabaseine", "dihydrochloride", "]", "were", "studied", "and", "compared", "with", "those", "of", "nicotine", ",", "9-amino-1,2,3,4-tetrahydroacridine", "hydrochloride", "hydrate", "THA", ")", "and", "C0030883#ent", "<e1>", "(", "PB", ")", "using", "a", "C0007785#ent", "<e2>", "model", "in", "Mongolian", "gerbils"], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [30, 31]}}
{"token": ["No", "differences", "be", "found", "between", "the", "initial", "bacteriuric", "and", "non-bacteriuric", "group", "concerning", "the", "number", "and", "complications", "of", "later", "pregnancies", ",", "C0042029#ent", "<e1>", "hospitalization", ",", "or", "recognized", "C0020538#ent", "<e2>"], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [26, 27]}}
{"token": ["Special", "emphasis", "will", "be", "placed", "on", "Swyer", ",", "Denys-Drash", ",", "RSH", ",", "GBBB", ",", "C1861923#ent", "<e1>", "and", "ATR-X", "syndromes", ",", "whose", "C0017337#ent", "<e2>", "were", "recently", "identified", "."], "h": {"id": "C1861923", "name": "C1861923#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [21, 22]}}
{"token": ["Analysis", "of", "SO", "X9", "in", "patients", "without", "chromosomal", "rearrangements", "single", "allele", "mutations", "sex", "reversed", "C1861923#ent", "<e1>", "individuals", ",", "linking", "this", "C0017337#ent", "<e2>", "with", "both", "bone", "formation", "control", "of", "testis", "development"], "h": {"id": "C1861923", "name": "C1861923#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["C0085084#ent", "<e1>", "MND", ")", "may", "be", "complicated", "by", "frontotemporal", "dementia", "an", "C0015371#ent", "<e2>"], "h": {"id": "C0085084", "name": "C0085084#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [11, 12]}}
{"token": ["Caffeine", "is", "a", "moderately", "strong", "stimulus", "of", "acid", "secretion", "C3540726#ent", "<e1>", ",", "phenylbutazone", ",", "ethanol", "and", "indomethacin", "are", "very", "weak", "C0304402#ent", "<e2>", "or", "have", "no", "effect"], "h": {"id": "C3540726", "name": "C3540726#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [20, 21]}}
{"token": ["We", "report", "here", "an", "unusual", "presentation", "of", "acute", "nonlymphoblastic", "leukemia", "ocular", "granulocytic", "sarcoma", "was", "firstly", "diagnosed", "C0162316#ent", "<e1>", "anemia", "and", "acute", "parvovirus", "infection", "induced", "C0015625#ent", "<e2>"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [24, 25]}}
{"token": ["Her", "bone", "marrow", "examination", "C0162316#ent", "<e1>", "megakaryocytopenia", ",", "and", "C0015625#ent", "<e2>", "no", "other", "evidence", "of", "a", "primary", "marrow", "disorder"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [9, 10]}}
{"token": ["There", "have", "been", "some", "observations", "on", "how", "new", "C0003308#ent", "<e1>", "such", "as", "voriconazole", "and", "C0537894#ent", "<e2>", "are", "impacting", "the", "shift", "in", "pathogens", "and", "drug", "resistance"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [8, 9]}, "relation": "therapeutic_class_of", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [14, 15]}}
{"token": ["Combination", "therapy", "C0003308#ent", "<e1>", "such", "as", "voriconazole", "plus", "C0537894#ent", "<e2>", "or", "liposomal", "amphotericin", "B", "is", "being", "investigated", "in", "vitro", "in", "animal", "models", "and", "optimistic", "results", "have", "been", "observed", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [8, 9]}}
{"token": ["All", "of", "the", "isolates", "were", "susceptible", "to", "all", "of", "the", "C0003308#ent", "<e1>", "tested", ",", "including", "amphotericin", "B", "fluconazole", ",", "voriconazole", ",", "and", "C0537894#ent", "<e2>", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [10, 11]}, "relation": "therapeutic_class_of", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [22, 23]}}
{"token": ["Patients", "with", "C1800706#ent", "<e1>", "IPF", ")", "were", "assessed", "as", "an", "example", "of", "C0004364#ent", "<e2>"], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [12, 13]}}
{"token": ["Carbohydrates", "substituted", "with", "phosphocholine", "(", "C1418943#ent", "<e1>", ")", "and", "phosphoethanolamine", "(", "PE", ")", "were", "released", "from", "C0017978#ent", "<e2>", "the", "pig", "parasitic", "nematode", "Ascaris", "suum", "treatment", "with", "endoglycoceramidase", "."], "h": {"id": "C1418943", "name": "C1418943#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017978", "name": "C0017978#ent", "pos": [16, 17]}}
{"token": ["In", "fact", ",", "the", "amount", "of", "C1418943#ent", "<e1>", "associated", "with", "Triton", "X-100-insoluble", "membrane", "fraction", "(", "highly", "enriched", "in", "C0017978#ent", "<e2>", "and", "cholesterol", "in", "nontreated", "cells", ")", "was", "lowered", "by", "the", "treatment", "."], "h": {"id": "C1418943", "name": "C1418943#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017978", "name": "C0017978#ent", "pos": [18, 19]}}
{"token": ["Cytoplasmic", "and", "nuclear", "levels", "C1334877#ent", "<e1>", "were", "not", "significantly", "altered", "in", "alveolar", "macrophages", "patients", "with", "established", "C0035222#ent", "<e2>", ",", "compared", "with", "controls", "."], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [16, 17]}}
{"token": ["After", "delivery", ",", "other", "forms", "of", "C0030517#ent", "<e1>", "occur", ",", "including", "Graves'", "disease", "transient", "hypothyroidism", "preceding", "destructive", "C0040156#ent", "<e2>", ",", "and", "persistent", "hypothyroidism", "."], "h": {"id": "C0030517", "name": "C0030517#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040156", "name": "C0040156#ent", "pos": [17, 18]}}
{"token": ["Various", "types", "of", "C0030517#ent", "<e1>", "namely", ",", "transient", "C0040156#ent", "<e2>", "followed", "by", "transient", "hypothyroidism", "transient", "C0040156#ent", "<e2>", "or", "hypothyroidism", "occurring", "alone", "or", "permanent", "hypothyroidism", "encountered", "."], "h": {"id": "C0030517", "name": "C0030517#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040156", "name": "C0040156#ent", "pos": [8, 9]}}
{"token": ["were", "evaluated", "for", "their", "intrinsic", "antimalarial", "activity", "in", "vitro", "C0008269#ent", "<e1>", "potentiating", "action", "against", "the", "chloroquine-resistant", "Plasmodium", "falciparum", "C3539916#ent", "<e2>", "29", "originating", "from", "Cameroon", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539916", "name": "C3539916#ent", "pos": [18, 19]}}
{"token": ["In", "an", "earlier", "study", ",", "however", ",", "we", "found", "surprisingly", "high", "levels", "of", "C1366565#ent", "<e1>", "in", "peritonitis", "exudate", "from", "patients", "with", "C0021845#ent", "<e2>"], "h": {"id": "C1366565", "name": "C1366565#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0021845", "name": "C0021845#ent", "pos": [21, 22]}}
{"token": ["A", "similar", "C1254351#ent", "<e1>", ",", "Ethacizine", ",", "had", "the", "same", "electrophysiologic", "effects", "as", "C0079856#ent", "<e2>", "HCl", "but", "was", "more", "potent.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079856", "name": "C0079856#ent", "pos": [13, 14]}}
{"token": ["Third", ",", "the", "expression", "of", "C0030956#ent", "<e1>", "in", "neurons", "of", "the", "C0085648#ent", "<e2>", "was", "sensitive", "to", "neonatal", "capsaicin", "treatment", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [11, 12]}}
{"token": ["By", "contrast", ",", "C0030956#ent", "<e1>", "levels", "did", "not", "increase", "in", "dissociated", "C0085648#ent", "<e2>", "cultures", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [11, 12]}}
{"token": ["The", "changes", "in", "C0030956#ent", "<e1>", "levels", "were", "accompanied", "by", "increases", "in", "C0085648#ent", "<e2>", "content", "of", "the", "preprotachykinin", "mRNA", "that", "codes", "for", "the", "peptide", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [11, 12]}}
{"token": ["HER-2", ",", "a", "C0033713#ent", "<e1>", "located", "on", "chromosome", "17q21", "encodes", "a", "C1415205#ent", "<e2>", "p185", ")", "with", "tyrosine", "kinase", "activity"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415205", "name": "C1415205#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "the", "linkage", "of", "mutations", "within", "the", "PRNP", "gene", "phenotypic", "appearance", "of", "C1418941#ent", "<e1>", "Gerstmann-Str\u00e4ussler-Scheinker", "syndrome", "to", "importance", "of", "the", "C0032027#ent", "<e2>"], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032027", "name": "C0032027#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "the", "linkage", "of", "mutations", "within", "the", "PRNP", "gene", "phenotypic", "appearance", "of", "Creutzfeldt-Jakob", "disease", "C1418941#ent", "<e1>", "to", "importance", "of", "the", "C0032027#ent", "<e2>"], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032027", "name": "C0032027#ent", "pos": [21, 22]}}
{"token": ["C0135615#ent", "<e1>", "PCs", ")", "are", "C2717971#ent", "<e2>", "after", "restricted", "proteolysis", "activate", "many", "proteins", "that", "play", "a", "crucial", "role", "in", "cancer", "such", "as", "metalloproteinases", ",", "growth", "factors", "growth", "factor", "receptors", "adhesion", "molecules", "and", "angiogenic", "factors"], "h": {"id": "C0135615", "name": "C0135615#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [5, 6]}}
{"token": ["Human", "herpesvirus-6", "HHV-6", ")", ",", "a", "ubiquitous", "virus", "that", "causes", "C0595993#ent", "<e1>", "occasional", "cases", "of", "C0021345#ent", "<e2>", "hepatitis", "and", "other", "viral", "syndromes", "has", "also", "been", "associated", "with", "acute", "lymphocytic", "leukemia", "ALL", ")", "in", "children", "."], "h": {"id": "C0595993", "name": "C0595993#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [15, 16]}}
{"token": ["Asthma", "severity", ",", "symptom", "score", "and", "C0006280#ent", "<e1>", "demonstrated", "significantly", "better", "results", "with", "C1538710#ent", "<e2>", "."], "h": {"id": "C0006280", "name": "C0006280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538710", "name": "C1538710#ent", "pos": [13, 14]}}
{"token": ["Another", "sicca", "condition", ",", "xerophthalmia", ",", "may", "result", "from", "facial", "nerve", "injury", "other", "C0003462#ent", "<e1>", "results", "in", "pain", ",", "C0010043#ent", "<e2>", "and", "possible", "vision", "loss"], "h": {"id": "C0003462", "name": "C0003462#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010043", "name": "C0010043#ent", "pos": [19, 20]}}
{"token": ["None", "of", "the", "C0002085#ent", "<e1>", "or", "haplotypes", "of", "IRAK-M", "and", "C1822724#ent", "<e2>", "were", "associated", "with", "asthma", "susceptibility", "asthma-related", "phenotype", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1822724", "name": "C1822724#ent", "pos": [10, 11]}}
{"token": ["The", "patient", "presented", "with", "a", "unique", "clinical", "syndrome", "high", "fever", "severe", "C0031350#ent", "<e1>", "buccal", "and", "pharyngeal", "ulcerations", "C0302809#ent", "<e2>", "thrombocytopenia", ",", "and", "leukopenia", "."], "h": {"id": "C0031350", "name": "C0031350#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0302809", "name": "C0302809#ent", "pos": [17, 18]}}
{"token": ["Using", "amino", "acid", "sequence", "alignment", "a", "molecular", "model", "the", "C0059735#ent", "<e1>", "was", "constructed", "by", "analogy", "to", "C0054563#ent", "<e2>", ",", "the", "bacterial", "protein", "which", "the", "3-dimensional", "structure", "known", "from", "X-ray", "crystallographic", "analysis"], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0054563", "name": "C0054563#ent", "pos": [16, 17]}}
{"token": ["A", "three-dimensional", "structure", "human", "C0059735#ent", "<e1>", "predicted", "based", "on", "the", "crystal", "coordinates", "C0054563#ent", "<e2>", "Pseudomonas", "putida"], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054563", "name": "C0054563#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "are", "relevant", "to", "the", "current", "outbreak", "of", "variant", "C0022336#ent", "<e1>", "C2347435#ent", "<e2>", ")", "in", "the", "United", "Kingdom", "because", "all", "C2347435#ent", "<e2>", "patients", "tested", "thus", "far", "have", "been", "M/M", "carriers", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [10, 11]}, "relation": "disease_has_associated_gene", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [12, 13]}}
{"token": ["They", "are", "various", "types", "of", "Gerstmann-Str\u00e4ussler-Scheinker", "syndrome(GSS", ")", ",", "fatal", "familial", "insomnia", "iatrogenic", "C0022336#ent", "<e1>", ",", "and", "variant", "C2347435#ent", "<e2>", "which", "suspected", "to", "have", "disseminated", "from", "bovine", "spongiform", "encephalopathy"], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [13, 14]}, "relation": "disease_has_associated_gene", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [18, 19]}}
{"token": ["An", "apparently", "new", "variant", "of", "C0022336#ent", "<e1>", "CJD", ")", ",", "new", "variant", "CJD", "(", "C2347435#ent", "<e2>", ")", ",", "was", "identified", "in", "the", "UK", "in", "1996", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [14, 15]}}
{"token": ["The", "progression", "of", "Creutzfeldt-Jakob", "disease", "C2347435#ent", "<e1>", ")", "was", "studied", "in", "ddY", "mice", "infected", "intraperitoneally", "with", "the", "Fukuoka-1", "strain", ",", "a", "C0022336#ent", "<e2>", "isolated", "from", "a", "C2347435#ent", "<e1>", "patient", "in", "Japan", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [21, 22]}, "relation": "disease_has_associated_gene", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [5, 6]}}
{"token": ["Compared", "with", "C1800706#ent", "<e1>", "patients", "and", "healthy", "volunteers", "patients", "with", "C0242900#ent", "<e2>", "had", "a", "significantly", "higher", "percentage", "of", "CD14(My4)+", "macrophages", ",", "whereas", "in", "sarcoidosis", "patients", "the", "numbers", "were", "reduced", "."], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242900", "name": "C0242900#ent", "pos": [10, 11]}}
{"token": ["Total", "plasma", "lactate", "dehydrogenase", "LDH", ")", "activity", "may", "be", "elevated", "in", "C1800706#ent", "<e1>", "CFA", ")", "and", "extrinsic", "allergic", "alveolitis", "C0242900#ent", "<e2>", ")", ",", "and", "may", "be", "a", "useful", "monitor", "of", "disease", "progress"], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242900", "name": "C0242900#ent", "pos": [19, 20]}}
{"token": ["The", "material", "comprises", "34", "patients", "with", "C0016977#ent", "<e1>", "20", "with", "obstructive", "jaundice", "8", "with", "C0023890#ent", "<e2>", "and", "3", "with", "haemochromatosis", "."], "h": {"id": "C0016977", "name": "C0016977#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [14, 15]}}
{"token": ["Acute", "bacterial", "cholangitis", "characterized", "by", "C0003892#ent", "<e1>", "pain", ",", "jaundice", "and", "fever", ")", "and", "the", "C0001339#ent", "<e2>", "its", "typical", "symptoms", "are", "the", "serious", "complications", "of", "common", "bile", "duct", "stones", ",", "associated", "with", "high", "mortality", "rate", "."], "h": {"id": "C0003892", "name": "C0003892#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [15, 16]}}
{"token": ["A", "number", "of", "differentiation-inducing", "substances", "been", "reported", ";", "these", "include", "C0022265#ent", "<e1>", "vitamin", "D3", "cytokines", "such", "as", "C1366463#ent", "<e2>", "tumor", "necrosis", "factor", "lymphotoxin", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366463", "name": "C1366463#ent", "pos": [17, 18]}}
{"token": ["We", "used", "C0022265#ent", "<e1>", "RA", ")", "as", "C1366463#ent", "<e2>", "cisdiaminodichloroplatinum", "(", "CDDP", ")", "as", "cytotoxic", "drug", "plus", "a", "combination", "of", "both", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366463", "name": "C1366463#ent", "pos": [7, 8]}}
{"token": ["The", "JURKAT", "cDNA", "(", "designated", "ptk-JURKAT", ")", "was", "homologous", "to", "but", "distinct", "from", "the", "C3853644#ent", "<e1>", ",", "yes", "and", "C0919478#ent", "<e2>", "which", "encode", "protein-tyrosine", "kinases", "ATP", ":", "protein", "phosphotransferase", "EC", "2.7.1.37", ")", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0919478", "name": "C0919478#ent", "pos": [19, 20]}}
{"token": ["The", "purpose", "of", "this", "experiment", "was", "to", "investigate", "the", "interactions", "of", "norepinephrine", "with", "C1422070#ent", "<e1>", "(", "phencyclidine", ")", "and", "sigma", "receptor", "agonists", "modulated", "GABA", "(", "C0242898#ent", "<e2>", "response", "in", "the", "cerebellum", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [25, 26]}}
{"token": ["Patients", "with", "DH", "have", "a", "high", "incidence", "of", "auto-immune", "disorders", "C0040128#ent", "<e1>", "pernicious", "anaemia", "and", "insulin-dependent", "diabetes", "and", "should", "be", "screened", "for", "those", "C0012634#ent", "<e2>", "on", "a", "yearly", "basis", "."], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [23, 24]}}
{"token": ["The", "euthyroid", "sick", "syndrome", "be", "interpreted", "not", "only", "in", "relation", "to", "the", "presence", "of", "C0040128#ent", "<e1>", "also", "in", "relation", "to", "the", "recovery", "from", "these", "C0012634#ent", "<e2>", "."], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["The", "goal", "of", "the", "present", "study", "was", "to", "evaluate", "serum", "activin", "A", "levels", "in", "a", "series", "of", "patients", "with", "different", "C0040128#ent", "<e1>", "the", "active", "state", "the", "C0012634#ent", "<e2>", "and", "after", "recovery", "."], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [26, 27]}}
{"token": ["Permeabilities", "to", "C0017868#ent", "<e1>", "and", "small", "non-electrolytes", "of", "three", "Aquaporin", "1", "CHIP", "C1412491#ent", "<e2>", ")", "water", "channels", "measured", "in", "C1412491#ent", "<e2>", "cRNA-injected", "Xenopus", "laevis", "oocytes", "and", "in", "human", "C1412491#ent", "<e2>", "channels", "reconstituted", "in", "proteoliposomes", "."], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412491", "name": "C1412491#ent", "pos": [12, 13]}}
{"token": ["C2713546#ent", "<e1>", "of", "this", "protein", "have", "been", "observed", "in", "C0037889#ent", "<e2>", "anaemia", ",", "suggesting", "a", "role", "of", "protein", "4.2", "in", "erythrocyte", "stability", "and", "integrity", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037889", "name": "C0037889#ent", "pos": [9, 10]}}
{"token": ["C2713546#ent", "<e1>", "of", "either", "alpha-", "or", "beta-spectrin", "can", "result", "in", "severe", "C0037889#ent", "<e2>", "HS", ")", "or", "hereditary", "elliptocytosis", "HE", ")", "in", "mice", "and", "humans", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037889", "name": "C0037889#ent", "pos": [11, 12]}}
{"token": ["Common", "C1949981#ent", "<e1>", "are", "usually", "treated", "by", "patients", "themselves", "with", "C0013231#ent", "<e2>", "(", "OTC", ")", "cold", "medications"], "h": {"id": "C1949981", "name": "C1949981#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013231", "name": "C0013231#ent", "pos": [10, 11]}}
{"token": ["More", "drastic", "changes", "are", "observed", "with", "the", "substrates", "D-xylose", "C0017718#ent", "<e1>", "and", "with", "the", "C0003015#ent", "<e2>", "and", "2-desoxy-D-glucose", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [14, 15]}}
{"token": ["Accumulation", "of", "14C-chlorozotocin", "was", "not", "inhibited", "by", "an", "excess", "of", "unlabeled", "chlorozotocin", ",", "the", "structural", "analogs", "glucose", "C0017718#ent", "<e1>", ",", "or", "several", "C0003015#ent", "<e2>", "by", "sodium", "ion", "depletion", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [22, 23]}}
{"token": ["Rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "is", "not", "only", "the", "most", "severe", "of", "all", "C0263661#ent", "<e2>", "also", "the", "most", "common", "systemic", "autoimmune", "disease", "approximately", "1", "%", "of", "the", "world-wide", "adult", "population", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [13, 14]}}
{"token": ["C0003873#ent", "<e1>", "RA", ")", "and", "osteoarthritis", "(", "OA", ")", "are", "C0263661#ent", "<e2>", "cause", "major", "public", "health", "problems"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [10, 11]}}
{"token": ["C3538890#ent", "<e1>", "and", "Cbk1", "act", "to", "properly", "localize", "C1412728#ent", "<e2>", ",", "a", "transcription", "factor", "directs", "daughter", "cell-specific", "transcription", "several", "genes", "."], "h": {"id": "C3538890", "name": "C3538890#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412728", "name": "C1412728#ent", "pos": [8, 9]}}
{"token": ["C0022336#ent", "<e1>", "(", "CJD", ")", "and", "C0002395#ent", "<e2>", "AD", ")", "are", "accompanied", "by", "selective", "neuronal", "loss", "the", "brain", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [6, 7]}}
{"token": ["Some", "differential", "diagnostic", "criteria", "presented", "permitting", "the", "differentiation", "of", "C0022336#ent", "<e1>", "from", "other", "atrophic", "processes", "by", "C0002395#ent", "<e2>", ",", "Pick", "and", "others", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [16, 17]}}
{"token": ["To", "investigate", "eventual", "mutual", "influences", ",", "we", "screened", "prominently", "affected", "neocortex", "from", "110", "neuropathologically", "proven", "C0022336#ent", "<e1>", "patients", "for", "C0002395#ent", "<e2>", "pathology", "with", "anti-beta/A4", ",", "Bielschowsky", "and", "anti-tau", "(immuno)stains", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}}
{"token": ["We", "have", "evaluated", "the", "levels", "of", "C2748507#ent", "<e1>", ",", "IL-6", "and", "IL-8", "in", "29", "C1422839#ent", "<e2>", "patients", "."], "h": {"id": "C2748507", "name": "C2748507#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422839", "name": "C1422839#ent", "pos": [14, 15]}}
{"token": ["We", "also", "investigate", "a", "series", "of", "C3653471#ent", "<e1>", "link", "amsacrine", "to", "C2827378#ent", "<e2>", "in", "terms", "of", "DNA", "binding", "topoisomerase", "poisoning", "biological", "activity"], "h": {"id": "C3653471", "name": "C3653471#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2827378", "name": "C2827378#ent", "pos": [11, 12]}}
{"token": ["C0600040#ent", "<e1>", "a", "poorly", "understood", "urological", "condition", "by", "C0030794#ent", "<e2>", "increased", "urinary", "frequency", "the", "absence", "of", "any", "known", "etiology", "."], "h": {"id": "C0600040", "name": "C0600040#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030794", "name": "C0030794#ent", "pos": [8, 9]}}
{"token": ["C0600040#ent", "<e1>", "chronic", "prostatitis/chronic", "pelvic", "pain", "syndrome", "are", "clinical", "syndromes", "by", "C0030794#ent", "<e2>", "or", "without", "voiding", "symptoms", "as", "urgency", "and", "frequency", "."], "h": {"id": "C0600040", "name": "C0600040#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030794", "name": "C0030794#ent", "pos": [11, 12]}}
{"token": ["This", "factor", "is", "probably", "prostacyclin", "for", "the", "relaxing", "effects", "of", "the", "C0243192#ent", "<e1>", "were", "negatively", "influenced", "by", "indomethacin", "and", "by", "C0040778#ent", "<e2>", ",", "two", "known", "antagonists", "of", "PGI2", "formation", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040778", "name": "C0040778#ent", "pos": [20, 21]}}
{"token": ["These", "studies", "indicate", "that", "vitamin", "E", "quantitatively", "C2712370#ent", "<e1>", "arachidonic", "acid", "metabolism", "in", "aortic", "and", "lung", "tissue", "its", "effect", "on", "C0040060#ent", "<e2>", "platelets", "is", "less", "marked", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040060", "name": "C0040060#ent", "pos": [20, 21]}}
{"token": ["We", "discuss", "whether", "activation", "of", "receptor", "tyrosine", "kinase", "a", "common", "pathway", "for", "neural", "induction", "bFGF", ",", "C0038597#ent", "<e1>", ",", "and", "cell-contact", "with", "C1705543#ent", "<e2>", "-", "1", "blastomeres", "."], "h": {"id": "C0038597", "name": "C0038597#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [22, 23]}}
{"token": ["Oligopeptides", "deduced", "from", "the", "sequence", "of", "one", "of", "the", "open", "reading", "frame", "C0079556#ent", "<e1>", "were", "synthesized", "chemically", ",", "and", "antibodies", "against", "these", "C0030956#ent", "<e2>", "were", "raised", "in", "rabbits", "."], "h": {"id": "C0079556", "name": "C0079556#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [22, 23]}}
{"token": ["To", "begin", "to", "characterize", "the", "specificity", "of", "C0079556#ent", "<e1>", ",", "we", "measured", "protease", "cleavage", "C0030956#ent", "<e2>", "substrates", "and", "inhibition", "by", "protease", "inhibitors"], "h": {"id": "C0079556", "name": "C0079556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}}
{"token": ["We", "sought", "to", "determine", "the", "extent", "to", "which", "C0030946#ent", "<e1>", "AEP", ")", "influences", "human", "Ag", "and", "C3273406#ent", "<e2>", "processing", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [16, 17]}}
{"token": ["Beside", "the", "major", "exoform", ",", "C0030946#ent", "<e1>", "two", "additional", "exoproteases", ",", "termed", "C3273406#ent", "<e2>", "and", "III", ",", "appeared", "in", "the", "medium", "of", "stationary", "cultures"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [12, 13]}}
{"token": ["Increasing", "concentrations", "of", "sodium", "dodecyl", "sulfate", "C0037506#ent", "<e1>", ")", "were", "also", "found", "to", "inhibit", "the", "C0030946#ent", "<e2>", "progressively", ",", "whereas", "a", "polyhexamethylene", "biguanidium", "chloride", "PHMBH+Cl-", ")", "and", "C0037506#ent", "<e1>", ":", "PHMBH+Cl-", "combination", "showed", "the", "opposite", "effect", "."], "h": {"id": "C0037506", "name": "C0037506#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "prorenin", "receptor", "blockers", "the", "decoy", "peptide", "may", "have", "superior", "benefits", "on", "end-organ", "damage", "in", "C0011847#ent", "<e1>", "and", "hypertension", "compared", "with", "conventional", "C0525678#ent", "<e2>", "inhibitors", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [23, 24]}}
{"token": ["Platelet-rich", "plasma", "was", "prepared", "from", "47", "patients", "with", "C0011860#ent", "<e1>", "treated", "with", "glibenclamide", "and", "C0770893#ent", "<e2>", ",", "and", "21", "controls", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [14, 15]}}
{"token": ["Despite", "their", "comparable", "glycaemic", "effects", "in", "patients", "with", "C0011860#ent", "<e1>", "T2DM", ")", ",", "pioglitazone", "and", "C0770893#ent", "<e2>", "may", "have", "different", "effects", "on", "insulin", "sensitivity", "they", "have", "different", "mechanisms", "of", "action", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [15, 16]}}
{"token": ["In", "this", "paper", ",", "the", "authors", "compare", "the", "long-term", "outcomes", "of", "translaminar", "facet", "screw", "fixation", "(", "TFSF", ")", "and", "pedicle", "screw", "fixation", "C2348113#ent", "<e1>", ")", "in", "the", "treatment", "of", "C1285162#ent", "<e2>"], "h": {"id": "C2348113", "name": "C2348113#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [29, 30]}}
{"token": ["C0015923#ent", "<e1>", "C1419956#ent", "<e2>", "expressed", "by", "all", "muscles", "where", "they", "promote", "(", "C0015923#ent", "<e1>", "or", "inhibit", "(", "C1419956#ent", "<e2>", "promiscuous", "synaptogenesis", "."], "h": {"id": "C0015923", "name": "C0015923#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419956", "name": "C1419956#ent", "pos": [2, 3]}}
{"token": ["These", "results", "suggest", "that", "C3540525#ent", "<e1>", "may", "separately", "stimulate", "keratinocyte", "proliferation", "terminal", "differentiation", "that", "Srex", "can", "substitute", "for", "C3540525#ent", "<e1>", "in", "the", "former", "but", "not", "the", "latter", "C1951340#ent", "<e1>", "."], "h": {"id": "C3540525", "name": "C3540525#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1951340", "name": "C1951340#ent", "pos": [27, 28]}}
{"token": ["The", "effects", "on", "athletic", "performance", "in", "relation", "to", "C4025182#ent", "<e1>", "changes", "in", "plasma", "C2697656#ent", "<e2>", "and", "anti-LPS", "IgG", "levels", "require", "further", "investigation", "."], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [13, 14]}}
{"token": ["Adult-onset", "Still's", "disease", "a", "C0221423#ent", "<e1>", "characterized", "by", "quotidian", "fever", "and", "a", "C0039070#ent", "<e2>", ",", "salmon-colored", "rash", "."], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039070", "name": "C0039070#ent", "pos": [12, 13]}}
{"token": ["C1321567#ent", "<e1>", "rats", "were", "exposed", "to", "min", "of", "complete", "C0007785#ent", "<e2>"], "h": {"id": "C1321567", "name": "C1321567#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [9, 10]}}
{"token": ["We", "examined", "different", "brain", "regions", "C1321567#ent", "<e1>", "and", "moderately", "hypoglycemic", "rats", "subjected", "to", "15", "min", "of", "C0007785#ent", "<e2>", "followed", "by", "recirculation", "for", "5", ",", "15", ",", "and", "30", "min", "."], "h": {"id": "C1321567", "name": "C1321567#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [16, 17]}}
{"token": ["The", "serum", "samples", "tested", "covered", "100", "non-endemic", "controls", ",", "190", "from", "patients", "with", "active", "schistosomiasis", "110", "from", "cured", "cases", "of", "C0036323#ent", "<e1>", ",", "and", "170", "from", "individuals", "harbouring", "other", "parasitic", "infections", "C0019158#ent", "<e2>", "."], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [31, 32]}}
{"token": ["Since", "C1414524#ent", "<e1>", "is", "a", "C0031686#ent", "<e2>", "we", "investigated", "whether", "it", "is", "a", "substrate", "for", "CK2", "."], "h": {"id": "C1414524", "name": "C1414524#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [5, 6]}}
{"token": ["The", "aqueous", "system", "used", "for", "the", "reduction", "reaction", "E.", "coli", "cells", "carrying", "a", "plasmid", "containing", "the", "C0879262#ent", "<e1>", "and", "GDH", "C1417679#ent", "<e2>", "as", "a", "catalyst", "is", "simple", "."], "h": {"id": "C0879262", "name": "C0879262#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["Histamine", ",", "ethylenediamine", "tetraacetic", "acid", "C0012695#ent", "<e1>", ")", ",", "ouabain", "and", "C0000981#ent", "<e2>", ",", "compounds", "known", "to", "alter", "acid", "production", "in", "gastric", "mucosa", "no", "effect", "jejunal", "acidification"], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000981", "name": "C0000981#ent", "pos": [11, 12]}}
{"token": ["The", "human", "C0618743#ent", "<e1>", "three", "closely", "related", "proteases", ":", "human", "kallikrein", "1", "hK1", ")", ",", "C1334308#ent", "<e2>", "hK2", ")", ",", "and", "prostate-specific", "antigen", "PSA", ")", "."], "h": {"id": "C0618743", "name": "C0618743#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334308", "name": "C1334308#ent", "pos": [15, 16]}}
{"token": ["Human", "glandular", "kallikrein", "C0618743#ent", "<e1>", ";", "encoded", "by", "the", "C1334308#ent", "<e2>", "is", "an", "emerging", "tumor", "marker", "prostate", "cancer"], "h": {"id": "C0618743", "name": "C0618743#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334308", "name": "C1334308#ent", "pos": [9, 10]}}
{"token": ["Controls", ",", "aged", "40", "years", "or", "over", ",", "were", "55", "hospitalized", "patients", "diagnosed", "as", "having", "C0740766#ent", "<e1>", "four", "outpatients", "with", "common", "C1949981#ent", "<e2>", "."], "h": {"id": "C0740766", "name": "C0740766#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1949981", "name": "C1949981#ent", "pos": [21, 22]}}
{"token": ["In", "cases", "with", "translocations", "involving", "C1705696#ent", "<e1>", ",", "the", "normal", "C1705696#ent", "<e1>", "C1706112#ent", "<e1>", "is", "often", "deleted", "."], "h": {"id": "C1705696", "name": "C1705696#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [12, 13]}}
{"token": ["Wild-type", "ETV6", "and", "ABL", "were", "also", "expressed", ",", "in", "accordance", "with", "the", "FISH", "results", "that", "showed", "no", "loss", "of", "the", "second", "C1705696#ent", "<e1>", "or", "ABL", "C1706112#ent", "<e2>", "."], "h": {"id": "C1705696", "name": "C1705696#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [25, 26]}}
{"token": ["Hyaluronidase", "and", "hyaluronic", "acid", "promising", "prognostic", "markers", "but", "C1615665#ent", "<e1>", "does", "not", "detect", "grade", "I", "C1861305#ent", "<e2>", "."], "h": {"id": "C1615665", "name": "C1615665#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1861305", "name": "C1861305#ent", "pos": [15, 16]}}
{"token": ["We", "have", "docked", "the", "C1335265#ent", "<e1>", "Ile1-Phe2-Pro3-Pro4-Val5-Pro6-Gly7-Pro8", ")", "to", "the", "ligand", "binding", "site", "of", "C3538849#ent", "<e2>", "."], "h": {"id": "C1335265", "name": "C1335265#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538849", "name": "C3538849#ent", "pos": [14, 15]}}
{"token": ["RNA", "blot", "analysis", "pC4AL1", "as", "a", "hybridization", "probe", "normal", "guinea", "pig", "C0023899#ent", "<e1>", "mRNA", "revealed", "a", "C4283853#ent", "<e2>", "mRNA", "of", "5.0", "kilobases", "(", "kb", ")", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [16, 17]}}
{"token": ["Exercise", "increased", "C0023899#ent", "<e1>", "and", "RG", "TBARS", "and", "C4283853#ent", "<e2>", "levels", "markedly", ",", "with", "similar", "levels", "in", "FOVE-Ex", "and", "SOVE-Ex", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [8, 9]}}
{"token": ["These", "data", "demonstrate", "the", "importance", "of", "the", "C0023899#ent", "<e1>", "in", "clearing", "C4283853#ent", "<e2>", "from", "the", "blood", "in", "rats", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [11, 12]}}
{"token": ["Both", "doses", "of", "C0004057#ent", "<e1>", "diminished", "the", "concentrations", "of", "PGI2", "and", "TXA2", "in", "C0027051#ent", "<e2>", "in", "contrast", ",", "small", "doses", "C0004057#ent", "<e1>", "failed", "to", "influence", "myocardial", "iNOS", "activity", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [13, 14]}}
{"token": ["In", "the", "viral", "sensitivity", "assay", "human", "embryonic", "lung", "fibroblasts", "are", "incubated", "with", "the", "virus", "C1875400#ent", "<e1>", "and", "different", "concentrations", "of", "the", "C3541353#ent", "<e2>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3541353", "name": "C3541353#ent", "pos": [21, 22]}}
{"token": ["The", "NUP98-HOXA13", "fusion", "protein", "of", "the", "N-terminal", "phenylalanine-glycine", "repeat", "motif", "of", "C1704853#ent", "<e1>", "and", "the", "C-terminal", "homeodomain", "C1415655#ent", "<e2>", ",", "similar", "to", "the", "NUP98-HOXA9", "fusion", "protein"], "h": {"id": "C1704853", "name": "C1704853#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415655", "name": "C1415655#ent", "pos": [17, 18]}}
{"token": ["Our", "recent", "work", "identifying", "C2348445#ent", "<e1>", "as", "an", "activator", "of", "the", "C1420466#ent", "<e2>", "a", "novel", "hub", "for", "such", "integrated", "signaling", "."], "h": {"id": "C2348445", "name": "C2348445#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420466", "name": "C1420466#ent", "pos": [11, 12]}}
{"token": ["By", "utilizing", "the", "ADW0.5", ",", "the", "number", "of", "subjects", "with", "C0039730#ent", "<e1>", "trait", ",", "particularly", "those", "with", "C0002312#ent", "<e2>", "detected", "in", "the", "south", "of", "The", "Netherlands", "was", "highly", "increased", "."], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0002312", "name": "C0002312#ent", "pos": [17, 18]}}
{"token": ["In", "recent", "years", "our", "efforts", "to", "control", "C0271441#ent", "<e1>", "children", "have", "focused", "on", "the", "treatment", "of", "C2242816#ent", "<e2>"], "h": {"id": "C0271441", "name": "C0271441#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2242816", "name": "C2242816#ent", "pos": [16, 17]}}
{"token": ["The", "approach", "is", "examined", "by", "using", "the", "Total", "Human", "Environmental", "Exposure", "Study", "THEES", ")", "for", "C0005080#ent", "<e1>", "as", "a", "potential", "model", "for", "low-risk", "C0003392#ent", "<e2>"], "h": {"id": "C0005080", "name": "C0005080#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [23, 24]}}
{"token": ["A", "28-year-old", "female", "developed", "infective", "endocarditis", "the", "tricuspid", "valve", "C0024110#ent", "<e1>", "to", "septic", "pulmonary", "emboli", "early", "after", "intensive", "therapy", "C0009324#ent", "<e2>"], "h": {"id": "C0024110", "name": "C0024110#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [19, 20]}}
{"token": ["Recent", "studies", "have", "demonstrated", "the", "presence", "of", "inflammatory", "cytokines", "as", "IL-1", "beta", "TNF-alpha", ",", "IL-6", ",", "and", "C1366571#ent", "<e1>", "in", "the", "C0029883#ent", "<e2>", "MEE", ")", "of", "patients", "with", "otitis", "media", "effusion", "(", "OME", ")", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0029883", "name": "C0029883#ent", "pos": [21, 22]}}
{"token": ["Importantly", ",", "inhibition", "of", "C1420464#ent", "<e1>", "a", "penetrant", "anti-proliferative", "phenotype", ",", "indicating", "that", "C3711547#ent", "<e2>", "an", "attractive", "anti-cancer", "drug", "target", "."], "h": {"id": "C1420464", "name": "C1420464#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3711547", "name": "C3711547#ent", "pos": [13, 14]}}
{"token": ["The", "C1420872#ent", "<e1>", "approximately", "15", "mg/liter", "of", "insect", "cell", "suspension", "polymerized", ",", "comigrated", "with", "C3811246#ent", "<e2>", "from", "muscle", "on", "two-dimensional", "polyacrylamide", "gels", "was", "blocked", "at", "the", "NH2", "terminus", "and", "had", "the", "same", "actin", "affinity", "muscle", "tropomyosin"], "h": {"id": "C1420872", "name": "C1420872#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811246", "name": "C3811246#ent", "pos": [14, 15]}}
{"token": ["This", "suggests", "the", "possibility", "of", "a", "fibroblast-specific", "function", "as", "opposed", "to", "a", "general", "nonmuscle-cell", "function", "for", "class", "1", "C1420872#ent", "<e1>", "and", "also", "has", "implications", "for", "the", "regulation", "of", "C3811246#ent", "<e2>", "during", "embryonic", "development"], "h": {"id": "C1420872", "name": "C1420872#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811246", "name": "C3811246#ent", "pos": [28, 29]}}
{"token": ["Expression", "of", "exogenous", "C1420872#ent", "<e1>", "to", "a", "concomitant", "decrease", "in", "endogenous", "C3811246#ent", "<e2>", "without", "altering", "the", "expression", "of", "other", "contractile", "proteins"], "h": {"id": "C1420872", "name": "C1420872#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811246", "name": "C3811246#ent", "pos": [11, 12]}}
{"token": ["In", "the", "C0271801#ent", "<e1>", "patient", "there", "was", "a", "low", "normal", "response", "C1705225#ent", "<e2>", ",", "the", "reason", "being", "unknown", "."], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [11, 12]}}
{"token": ["Four", "of", "them", "were", "C0271801#ent", "<e1>", "one", "to", "four", "months", "after", "surgery", "and", "had", "no", "response", "C1705225#ent", "<e2>", "."], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [16, 17]}}
{"token": ["Two", "out", "of", "four", "C0271801#ent", "<e1>", "patients", "also", "showed", "an", "increased", "response", "of", "TSH", "to", "C1705225#ent", "<e2>", "."], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [15, 16]}}
{"token": ["The", "influence", "of", "C0006230#ent", "<e1>", "(", "CB-154", ")", "and", "2-chloro-6-methyl-ergoline-8beta-acetonitrile", "methanesulfonate", "(", "C0023369#ent", "<e2>", "on", "prolactin", "(", "PRL", ")", "and", "growth", "hormone", "GH", ")", "secretion", "in", "mice", "was", "investigated", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023369", "name": "C0023369#ent", "pos": [12, 13]}}
{"token": ["On", "the", "other", "hand", ",", "histamine", "caused", "endothelium-dependent", "relaxation", "C1422341#ent", "<e1>", ")", "in", "monkey", "and", "C1832097#ent", "<e2>", "in", "canine", "basilar", "arteries"], "h": {"id": "C1422341", "name": "C1422341#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1832097", "name": "C1832097#ent", "pos": [15, 16]}}
{"token": ["Histamine", "caused", "endothelium-dependent", "relaxation", "C1422341#ent", "<e1>", ")", "in", "monkey", "basilar", "arteries", "and", "C1832097#ent", "<e2>", "in", "canine", "basilar", "arteries"], "h": {"id": "C1422341", "name": "C1422341#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1832097", "name": "C1832097#ent", "pos": [12, 13]}}
{"token": ["L-N(G)-nitro-arginine", "methyl", "ester", "10(-5", ")", "-", "10(-4", ")", "M", ")", ",", "a", "nitric", "oxide", "synthase", "inhibitor", "attenuated", "the", "C1422341#ent", "<e1>", "and", "slightly", "potentiated", "the", "C1832097#ent", "<e2>", "."], "h": {"id": "C1422341", "name": "C1422341#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1832097", "name": "C1832097#ent", "pos": [24, 25]}}
{"token": ["The", "SP-induced", "endothelium-dependent", "relaxation", "C1422341#ent", "<e1>", ")", "was", "suppressed", ",", "while", "the", "endothelium-dependent", "contraction", "C1832097#ent", "<e2>", ")", "was", "increased", "by", "repeated", "application", "."], "h": {"id": "C1422341", "name": "C1422341#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1832097", "name": "C1832097#ent", "pos": [14, 15]}}
{"token": ["The", "p53", "inhibitor", "pifithrin-alpha", "or", "p53", "siRNA", "prevented", "both", "cisplatin-induced", "C1453171#ent", "<e1>", "activation", "and", "mitochondrial", "release", "of", "C1826618#ent", "<e2>", "."], "h": {"id": "C1453171", "name": "C1453171#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1826618", "name": "C1826618#ent", "pos": [17, 18]}}
{"token": ["Overexpression", "of", "p53", "not", "only", "resulted", "in", "C1453171#ent", "<e1>", "activation", "but", "also", "mitochondrial", "release", "of", "C1826618#ent", "<e2>", "."], "h": {"id": "C1453171", "name": "C1453171#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826618", "name": "C1826618#ent", "pos": [15, 16]}}
{"token": ["Within", "the", "nucleolus", ",", "C3273671#ent", "<e1>", "colocalizes", "with", "the", "C1421307#ent", "<e2>", "interphasic", "cells", "indicating", "that", "C3273671#ent", "<e1>", "may", "be", "involved", "in", "the", "regulation", "of", "rRNA", "transcription"], "h": {"id": "C1421307", "name": "C1421307#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273671", "name": "C3273671#ent", "pos": [4, 5]}}
{"token": ["To", "inhibit", "metastatic", "potential", ",", "C0812204#ent", "<e1>", "is", "also", "demonstrated", "to", "co-immunoprecipitate", "the", "C1825781#ent", "<e2>", "Ras", "and", "phosphorylate", "it", ",", "and", "therefore", "reduce", "activation", "of", "the", "extracellular", "signal-regulated", "kinase", "mitogen-activated", "protein", "kinase", "pathway", "response", "to", "signaling", "."], "h": {"id": "C0812204", "name": "C0812204#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1825781", "name": "C1825781#ent", "pos": [13, 14]}}
{"token": ["Phosphoamino", "acid", "analysis", "serine", "as", "the", "major", "target", ",", "and", "two", "peaks", "of", "C0812204#ent", "<e1>", "phosphorylation", "were", "identified", "upon", "high", "performance", "liquid", "chromatography", "analysis", "C1825781#ent", "<e2>", "tryptic", "peptides", "."], "h": {"id": "C0812204", "name": "C0812204#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1825781", "name": "C1825781#ent", "pos": [24, 25]}}
{"token": ["Furthermore", ",", "C0016971#ent", "<e1>", "decelerated", "the", "rate", "of", "dissociation", "of", "C1333707#ent", "<e2>", "[3H]NMS", "greater", "than", "[3H]NMeQNB", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0016971", "name": "C0016971#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333707", "name": "C1333707#ent", "pos": [10, 11]}}
{"token": ["Myotonic", "dystrophy", "DM", ")", "is", "an", "C3899989#ent", "<e1>", "myotonia", ",", "progressive", "C0151786#ent", "<e2>", "and", "endocrine", "abnormalities", "hypothalamic-pituitary-adrenal", "(HPA)", "axis", "hyperresponsiveness", "CRH-mediated", "stimuli", "."], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151786", "name": "C0151786#ent", "pos": [11, 12]}}
{"token": ["Spinal", "bumetanide", "10", "and", "100", "microM", "blocked", "neurogenic", "edema", "when", "it", "was", "administered", "before", "CAP", "injection", ",", "but", "only", "C0006376#ent", "<e1>", "at", "100", "microM", "administered", "after", "CAP", "injection", "reduced", "the", "C0013604#ent", "<e2>", "."], "h": {"id": "C0006376", "name": "C0006376#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [30, 31]}}
{"token": ["Because", "it", "is", "chemically", "different", "from", "existing", "diuretics", ",", "C0006376#ent", "<e1>", "may", "be", "helpful", "in", "C0013604#ent", "<e2>", "resistant", "to", "other", "drugs", "."], "h": {"id": "C0006376", "name": "C0006376#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [15, 16]}}
{"token": ["C1416959#ent", "<e1>", ",", "the", "human", "homologue", "of", "C3813577#ent", "<e2>", "MAD2", ")", ",", "is", "a", "key", "component", "of", "the", "mitotic", "checkpoint", "system"], "h": {"id": "C1416959", "name": "C1416959#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3813577", "name": "C3813577#ent", "pos": [7, 8]}}
{"token": ["In", "FUMIC", "patients", ",", "FUcont", "was", "associated", "with", "weekly", "C1161438#ent", "<e1>", "bolus", "(", "300", "mg/m2", ")", "and", "monthly", "C0026254#ent", "<e2>", "10", "mg/m2", ")", "."], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [18, 19]}}
{"token": ["Other", "active", "agents", "cisplatin", ",", "C1161438#ent", "<e1>", ",", "5-fluorouracil", ",", "ifosfamide", ",", "methotrexate", ",", "C0026254#ent", "<e2>", ",", "mitoxantrone", ",", "vinblastine", ",", "and", "vincristine", "."], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [14, 15]}}
{"token": ["Chromatin", "immunoprecipitation", "ChIP", ")", "assay", "showed", "that", "C1417708#ent", "<e1>", "was", "indeed", "bound", "to", "the", "C0072632#ent", "<e2>", "promoter", "after", "CHX", "treatment", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072632", "name": "C0072632#ent", "pos": [14, 15]}}
{"token": ["The", "metabolism", "of", "D-glucose", "and/or", "C0016745#ent", "<e1>", "was", "investigated", "in", "pancreatic", "islets", "control", "rats", "and", "hereditarily", "diabetic", "C1415014#ent", "<e2>", "rats", "."], "h": {"id": "C0016745", "name": "C0016745#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415014", "name": "C1415014#ent", "pos": [17, 18]}}
{"token": ["Increased", "levels", "of", "C1439334#ent", "<e1>", "and", "DHLA", "were", "present", "in", "the", "plasma", "phospholipid", "fraction", "of", "animals", "C0342895#ent", "<e2>", "the", "black", "currant", "seed", "oil", "diet", "while", "soy-fed", "animals", "had", "only", "trace", "amounts", "C1439334#ent", "<e1>", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1439334", "name": "C1439334#ent", "pos": [3, 4]}}
{"token": ["C0795650#ent", "<e1>", "has", "been", "shown", "to", "control", "acid", "production", "in", "C0043515#ent", "<e2>"], "h": {"id": "C0795650", "name": "C0795650#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [10, 11]}}
{"token": ["It", "is", "postulated", "that", "C0012798#ent", "<e1>", "exacerbate", "the", "hyperparathyroidism", "which", "complicates", "C0035086#ent", "<e2>"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [11, 12]}}
{"token": ["However", ",", "in", "the", "long", "term", "the", "C0012798#ent", "<e1>", "effects", "diminish", "because", "of", "progression", "of", "the", "underlying", "C0035086#ent", "<e2>"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [17, 18]}}
{"token": ["C0018133#ent", "<e1>", "GVHD", ")", "is", "an", "C0021053#ent", "<e2>", "occurs", "frequently", "after", "allogeneic", "hematopoietic", "cell", "transplantation", "HCT", ")", "."], "h": {"id": "C0018133", "name": "C0018133#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [6, 7]}}
{"token": ["Mutations", "in", "2", "C0017337#ent", "<e1>", "involved", "in", "deoxyribonucleotide", "metabolism", "the", "C1414038#ent", "<e2>", "DGK", ")", "and", "the", "thymidine", "kinase", "2", "gene", "TK2", ")", ",", "have", "been", "related", "to", "this", "syndrome", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414038", "name": "C1414038#ent", "pos": [10, 11]}}
{"token": ["This", "interval", "encompasses", "the", "C0017337#ent", "<e1>", "(", "DGUOK", ")", "encoding", "the", "C1414038#ent", "<e2>", "dGK", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414038", "name": "C1414038#ent", "pos": [11, 12]}}
{"token": ["The", "phenotype", "was", "distinctive", "for", "each", "C0017337#ent", "<e1>", ",", "with", "hepatic", "failure", "encephalopathy", "associated", "with", "mutations", "in", "the", "C1414038#ent", "<e2>", "isolated", "devastating", "myopathy", "as", "the", "sole", "manifestation", "of", "thymidine", "kinase", "2", "deficiency"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414038", "name": "C1414038#ent", "pos": [18, 19]}}
{"token": ["We", "recently", "showed", "that", "GH", "mainly", "stimulated", "tyrosine", "phosphorylation", "C1414313#ent", "<e1>", "its", "association", "with", "Grb2", ",", "and", "concomitantly", "stimulated", "mitogen-activated", "protein", "kinase", "activity", "C0023899#ent", "<e2>", ",", "a", "major", "target", "tissue", "."], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [23, 24]}}
{"token": ["A", "detailed", "pharmacological", "analysis", "long-term", "ovariectomized", "females", "confirmed", "previous", "reports", "that", "adrenergic", "and", "C0242702#ent", "<e1>", "enhance", "secretion", "of", "C1415169#ent", "<e2>", "and", "LH", "and", "opioid", "receptor", "agonists", "suppress", "it", "."], "h": {"id": "C0242702", "name": "C0242702#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [18, 19]}}
{"token": ["The", "present", "results", "provide", "evidence", "that", "mutations", "in", "C0271829#ent", "<e1>", "cause", "both", "C0039082#ent", "<e2>", "and", "non-syndromic", "hearing", "loss", "."], "h": {"id": "C0271829", "name": "C0271829#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}}
{"token": ["alpha3", "And", "beta4", "mRNAs", "were", "highly", "expressed", "in", "the", "dorsal", "region", "the", "C1417869#ent", "<e1>", ",", "whereas", "dense", "C1414430#ent", "<e2>", "mRNA", "expression", "was", "restricted", "to", "the", "DMV", "and", "ventral", "NTS"], "h": {"id": "C1417869", "name": "C1417869#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414430", "name": "C1414430#ent", "pos": [17, 18]}}
{"token": ["The", "clinical", "efficacy", "thrombolytic", "agents", "urokinase", ",", "C0065410#ent", "<e1>", "and", "batroxobin", ",", "was", "evaluated", "on", "the", "patients", "with", "C0149871#ent", "<e2>"], "h": {"id": "C0065410", "name": "C0065410#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [18, 19]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "investigate", "whether", "the", "genetic", "polymorphisms", "preproET-1", ",", "EDNRA", "and", "EDNRB", "C0017337#ent", "<e1>", "were", "associated", "with", "degree", "of", "C0001883#ent", "<e2>", "assessed", "by", "FEV1", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "overexpression", "of", "C1418640#ent", "<e1>", "in", "R-VTA", "causes", "increased", "preference", "for", "C1161331#ent", "<e2>", "and", "increased", "anxiety-like", "behavior", "but", "does", "not", "affect", "responses", "to", "stress", "or", "nociceptive", "stimuli"], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", ",", "besides", "OTSC1", "and", "C1854022#ent", "<e1>", ",", "there", "must", "be", "at", "least", "one", "additional", "C1418199#ent", "<e2>", "locus", "."], "h": {"id": "C1854022", "name": "C1854022#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418199", "name": "C1418199#ent", "pos": [18, 19]}}
{"token": ["In", "two", "families", ",", "results", "compatible", "with", "linkage", "to", "C1854022#ent", "<e1>", "were", "found", ",", "but", "in", "the", "seven", "remaining", "families", "C1418199#ent", "<e2>", "and", "C1854022#ent", "<e1>", "were", "excluded", "."], "h": {"id": "C1854022", "name": "C1854022#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418199", "name": "C1418199#ent", "pos": [20, 21]}}
{"token": ["Moreover", "atropine", ",", "an", "C0242897#ent", "<e1>", "affects", "carnitine", "distribution", "in", "a", "way", "similar", "to", "C0013615#ent", "<e2>", "."], "h": {"id": "C0242897", "name": "C0242897#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013615", "name": "C0013615#ent", "pos": [14, 15]}}
{"token": ["Clinical", "application", "these", "C0035064#ent", "<e1>", "is", "often", "associated", "with", "dose-dependent", "C3276706#ent", "<e2>", "to", "damages", "to", "the", "peripheral", "axons"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3276706", "name": "C3276706#ent", "pos": [10, 11]}}
{"token": ["Chronic", "myeloid", "leukemia", "CML", ")", "is", "characterized", "by", "the", "Philadelphia", "translocation", "fuses", "C0105421#ent", "<e1>", "sequences", "from", "chromosome", "22", "of", "the", "C0080279#ent", "<e2>", "chromosome", "9"], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [20, 21]}}
{"token": ["Accordingly", ",", "we", "have", "isolated", "panels", "of", "scFv", "that", "bind", "intracellularly", "to", "the", "C0105421#ent", "<e1>", "or", "the", "C0080279#ent", "<e2>", "parts", "of", "the", "BCR-ABL", "oncogenic", "protein"], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [17, 18]}}
{"token": ["C0105421#ent", "<e1>", "is", "a", "multifunctional", "protein", "is", "the", "fusion", "partner", "for", "C0080279#ent", "<e2>", "(", "p210", "Bcr-Abl", ")", "in", "Philadelphia", "chromosome", "positive", "leukemias"], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "they", "suggest", "that", "downstream", "C0285558#ent", "<e1>", "effects", "are", "primarily", "mediated", "by", "C0073337#ent", "<e2>", "thus", "enhancing", "proliferation", "rather", "than", "inhibiting", "apoptosis", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0073337", "name": "C0073337#ent", "pos": [13, 14]}}
{"token": ["The", "mainstay", "in", "the", "acute", "treatment", "C0149931#ent", "<e1>", "is", "triptans", "(", "sumatriptan", ",", "zolmitriptan", ",", "C0759933#ent", "<e2>", ",", "naratriptan", ")", "and", "analgesics", "or", "NSAIDs", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0759933", "name": "C0759933#ent", "pos": [15, 16]}}
{"token": ["These", "data", "demonstrate", "that", "the", "defluorination", "of", "TFE", "in", "vivo", "the", "C1382176#ent", "<e1>", "increased", "by", "C0022180#ent", "<e2>", ",", "and", "that", "C0022180#ent", "<e2>", "enhances", "the", "ability", "of", "TFE", "to", "inactivate", "cytochromes", "P450", "an", "isozyme-selective", "manner", "."], "h": {"id": "C1382176", "name": "C1382176#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [15, 16]}}
{"token": ["The", "structure", "of", "Clostridium", "thermocellum", "endoglucanase", "C1332682#ent", "<e1>", ",", "a", "member", "of", "the", "largest", "C0007641#ent", "<e2>", "family", "A", ",", "has", "been", "determined", "at", "2.15", "A", "resolution", "."], "h": {"id": "C1332682", "name": "C1332682#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007641", "name": "C0007641#ent", "pos": [14, 15]}}
{"token": ["The", "permanent", "Urolume", "Wallstent", "has", "been", "used", "for", "the", "relief", "of", "C0005694#ent", "<e1>", "BOO", ")", ",", "detrusor-external", "sphincter", "dyssnergia", "(", "C1422033#ent", "<e2>", ")", ",", "and", "recurrent", "bulbar", "urethral", "strictures"], "h": {"id": "C0005694", "name": "C0005694#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422033", "name": "C1422033#ent", "pos": [20, 21]}}
{"token": ["Plasma", "concentrations", "of", "adrenomedullin", "(", "C3813124#ent", "<e1>", ")", "are", "markedly", "increased", "during", "C0243026#ent", "<e2>", ",", "but", "the", "role", "of", "C3813124#ent", "<e1>", "has", "not", "been", "clarified", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}}
{"token": ["Patients", "with", "C0687751#ent", "<e1>", "exhibit", "symptoms", "of", "self-biting", ",", "choreic", "movement", ",", "and", "C0000744#ent", "<e2>", ",", "but", "not", "dementia", "."], "h": {"id": "C0687751", "name": "C0687751#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [13, 14]}}
{"token": ["These", "clinical", "and", "laboratory", "characteristics", "are", "consistent", "with", "of", "previously", "reported", "cases", "of", "C0687751#ent", "<e1>", ",", "ie", ",", "familial", "amyotrophic", "chorea", "with", "C0000744#ent", "<e2>", "(", "FACWA", ")", "."], "h": {"id": "C0687751", "name": "C0687751#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "replacement", "of", "the", "N-terminal", "region", "of", "C2680450#ent", "<e1>", "with", "the", "corresponding", "region", "of", "Delta", "abolishes", "the", "ability", "of", "C1334504#ent", "<e2>", "to", "regulate", "C2680450#ent", "<e1>", "without", "altering", "Serrate-specific", "signaling", "."], "h": {"id": "C1334504", "name": "C1334504#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2680450", "name": "C2680450#ent", "pos": [8, 9]}}
{"token": ["A", "putative", "secretory", "protein", "C1334504#ent", "<e1>", ",", "is", "indispensable", "for", "the", "wing", "margin", "formation", "inducing", "C2680450#ent", "<e2>", "and", "other", "genes", "."], "h": {"id": "C1334504", "name": "C1334504#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2680450", "name": "C2680450#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", "the", "transient", "expression", "of", "C1417092#ent", "<e1>", "is", "apparently", "due", "to", "C1710463#ent", "<e2>"], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "compare", "the", "efficacy", "of", "metronidazole", "and", "C0029274#ent", "<e1>", "in", "the", "treatment", "of", "C0040928#ent", "<e2>", "men", "."], "h": {"id": "C0029274", "name": "C0029274#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040928", "name": "C0040928#ent", "pos": [19, 20]}}
{"token": ["In", "C0341439#ent", "<e1>", "including", "the", "clinical", "phase", "C0162566#ent", "<e2>", "the", "activity", "of", "uroporphyrinogen", "decarboxylase", "decreased", "not", "only", "in", "the", "liver", ",", "but", "also", "in", "the", "erythrocytes", "."], "h": {"id": "C0341439", "name": "C0341439#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [7, 8]}}
{"token": ["Our", "data", "suggest", "that", "entry", "into", "prophase", "leads", "to", "a", "loss", "of", "tethering", "between", "regions", "of", "C0008546#ent", "<e1>", "and", "PML", "C1303073#ent", "<e2>", ",", "resulting", "in", "their", "increased", "dynamics", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1303073", "name": "C1303073#ent", "pos": [20, 21]}}
{"token": ["In", "the", "subjects", "studied", "there", "was", "no", "major", "difference", "in", "the", "rate", "of", "elimination", "although", "the", "amount", "of", "C0055753#ent", "<e1>", "was", "less", "in", "those", "with", "C0031485#ent", "<e2>", "."], "h": {"id": "C0055753", "name": "C0055753#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [25, 26]}}
{"token": ["C0019069#ent", "<e1>", "an", "inherited", "bleeding", "disorder", "characterized", "by", "C3494187#ent", "<e2>"], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C3494187", "name": "C3494187#ent", "pos": [8, 9]}}
{"token": ["C0019069#ent", "<e1>", "an", "X-linked", "congenital", "bleeding", "disorder", "by", "C3494187#ent", "<e2>"], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C3494187", "name": "C3494187#ent", "pos": [8, 9]}}
{"token": ["3", ")", "Several", "authors", "reported", "that", "some", "PSP", "cases", "could", "show", "only", "C0085623#ent", "<e1>", "initially", ",", "later", "developing", "dementia", ",", "C1408507#ent", "<e2>", "pseundobulbar", "palsy", "and", "nuchal", "rigidity", "their", "illnesses", "."], "h": {"id": "C0085623", "name": "C0085623#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1408507", "name": "C1408507#ent", "pos": [20, 21]}}
{"token": ["Growth", "inhibition", "apoptosis", "were", "significantly", "(", "P", "<", "0.05", ")", "higher", "in", "BxPC-3", ",", "HPAC", ",", "and", "PANC-1", "cells", "treated", "with", "C0538927#ent", "<e1>", "and", "C1533491#ent", "<e2>", "than", "cells", "treated", "with", "C0538927#ent", "<e1>", "or", "C1533491#ent", "<e2>", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1533491", "name": "C1533491#ent", "pos": [24, 25]}}
{"token": ["There", "was", "no", "difference", "between", "C1414863#ent", "<e1>", ",", "CHESS", ",", "and", "FLASH", "in", "the", "detection", "of", "C0007302#ent", "<e2>"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007302", "name": "C0007302#ent", "pos": [16, 17]}}
{"token": ["CHESS-water", "and", "FLASH", "images", "proved", "superior", "to", "C1414863#ent", "<e1>", "images", "in", "demonstrating", "C0007302#ent", "<e2>"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007302", "name": "C0007302#ent", "pos": [12, 13]}}
{"token": ["This", "paper", "describes", "the", "design", ",", "synthesis", "and", "evaluation", "of", "a", "series", "of", "C0045478#ent", "<e1>", "as", "inhibitors", "of", "leishmanial", "and", "C0039667#ent", "<e2>"], "h": {"id": "C0045478", "name": "C0045478#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [20, 21]}}
{"token": ["Trimetrexate", "is", "a", "C0045478#ent", "<e1>", "inhibitor", "of", "C0039667#ent", "<e2>", "DHFR", ")", "which", "is", "cytotoxic", "in", "vitro", "in", "vivo", "several", "tumors", "resistant", "to", "methotrexate", "."], "h": {"id": "C0045478", "name": "C0045478#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [7, 8]}}
{"token": ["Evidence", "is", "presented", "to", "suggest", "that", "C0045478#ent", "<e1>", "bind", "to", "C0039667#ent", "<e2>", "in", "the", "same", "manner", "as", "do", "2,4-diaminopteridines", "."], "h": {"id": "C0045478", "name": "C0045478#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [10, 11]}}
{"token": ["Treating", "recipient", "mice", "C0677829#ent", "<e1>", "(", "recombinant", "human", "C0064294#ent", "<e2>", "prevents", "the", "development", "of", "acute", ",", "lethal", ",", "graft-versus-host", "disease", "GVHD", ")", "."], "h": {"id": "C0677829", "name": "C0677829#ent", "pos": [3, 4]}, "relation": "has_structural_class", "t": {"id": "C0064294", "name": "C0064294#ent", "pos": [8, 9]}}
{"token": ["C0677829#ent", "<e1>", "(", "recombinant", "human", "C0064294#ent", "<e2>", "prevents", "the", "development", "of", "acute", ",", "lethal", "graft-versus-host", "disease", "GVHD", ")", "."], "h": {"id": "C0677829", "name": "C0677829#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0064294", "name": "C0064294#ent", "pos": [5, 6]}}
{"token": ["Thiazides", "and", "C0012798#ent", "<e1>", "the", "loss", "of", "K", "Mg", "through", "the", "kidneys", "leading", "to", "C2713546#ent", "<e2>", "that", "may", "require", "treatment", "with", "supplements", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [14, 15]}}
{"token": ["C0009663#ent", "<e1>", "acuminata(CA", ")", "is", "one", "of", "C0036916#ent", "<e2>", ")", "caused", "by", "human", "papillomavirus(HPV", ")", "."], "h": {"id": "C0009663", "name": "C0009663#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [7, 8]}}
{"token": ["This", "genetic", "resistance", "on", "complementation", "of", "C0678928#ent", "<e1>", "complementation", "of", "genes", "outside", "the", "C1588750#ent", "<e2>"], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1588750", "name": "C1588750#ent", "pos": [13, 14]}}
{"token": ["This", "review", "summarizes", "our", "current", "view", "on", "involvement", "of", "Nur77", ",", "C1417836#ent", "<e1>", ",", "and", "NOR-1", "in", "C0004153#ent", "<e2>", "discusses", "NR4A", "function", "in", "vascular", "response", "injury", "."], "h": {"id": "C1417836", "name": "C1417836#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [17, 18]}}
{"token": ["The", "inhibition", "of", "phospholipase", "C", "C1620102#ent", "<e1>", "(", "3", "microM", ")", "and", "of", "the", "C0916181#ent", "<e2>", "thapsigargin", "(", "1", "microM", ")", "did", "not", "modify", "the", "ATP-induced", "relaxation", "."], "h": {"id": "C1620102", "name": "C1620102#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0916181", "name": "C0916181#ent", "pos": [14, 15]}}
{"token": ["Both", "the", "phospholipase", "C", "inhibitor", "C1620102#ent", "<e1>", "and", "the", "C0916181#ent", "<e2>", "thapsigargin", "inhibited", "the", "vasorelaxant", "effect", "of", "phenylephrine", "."], "h": {"id": "C1620102", "name": "C1620102#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0916181", "name": "C0916181#ent", "pos": [9, 10]}}
{"token": ["Inhibition", "of", "phospholipase", "C", "PLC", ")", "with", "C1620102#ent", "<e1>", "or", "inhibition", "of", "C0916181#ent", "<e2>", "cyclopiazonic", "acid", "thapsigargin", "abolished", "the", "rise", "of", "(", "[Ca2+](i", ")", ")", "."], "h": {"id": "C1620102", "name": "C1620102#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0916181", "name": "C0916181#ent", "pos": [12, 13]}}
{"token": ["At", "higher", "concentrations", "C0009074#ent", "<e1>", "and", "miconazole", "are", "C0003308#ent", "<e2>", ",", "whereas", "ketoconazole", "is", "not", "."], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [3, 4]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [8, 9]}}
{"token": ["C0009074#ent", "<e1>", "is", "a", "new", "C0003308#ent", "<e2>", "is", "effective", "topically", "in", "dermatophytosis", ",", "cutaneous", "candidiasis", "and", "tinea", "vesicolor"], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [5, 6]}}
{"token": ["In", "vitro", "experiments", "showed", "that", "blocking", "C2984583#ent", "<e1>", "prevented", "the", "ability", "of", "C1334089#ent", "<e2>", "to", "stimulate", "IGFBP-4", "proteolysis", "."], "h": {"id": "C2984583", "name": "C2984583#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [12, 13]}}
{"token": ["The", "ability", "of", "parenteral", "heparin", "to", "release", "the", "capillary-bound", "enzymes", "lipoprotein", "lipase", "(", "LPL", ")", "and", "hepatic", "triglyceride", "lipase", "C2826547#ent", "<e1>", ")", "into", "the", "circulation", "is", "shared", "by", "several", "other", "C0019142#ent", "<e2>"], "h": {"id": "C2826547", "name": "C2826547#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0019142", "name": "C0019142#ent", "pos": [30, 31]}}
{"token": ["Moreover", ",", "the", "repulsive", "guidance", "cue", "C1419942#ent", "<e1>", "which", "signals", "through", "C1419407#ent", "<e2>", ",", "destabilizes", "point", "contacts", "."], "h": {"id": "C1419942", "name": "C1419942#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419407", "name": "C1419407#ent", "pos": [11, 12]}}
{"token": ["Drug", "abusers", "a", "low", "tolerance", "unpleasant", "and", "C0239377#ent", "<e1>", "emotions", "and", "experience", "a", "need", "for", "C0723011#ent", "<e2>", "use", "of", "narcotics", ",", "tranquilizers", "and", "analgesics", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0723011", "name": "C0723011#ent", "pos": [15, 16]}}
{"token": ["Collectively", ",", "these", "results", "indicate", "a", "novel", "function", "for", "C1418226#ent", "<e1>", "in", "contributing", "to", "the", "regulation", "of", "C1704467#ent", "<e2>", "expression", "in", "HL-60", "cells"], "h": {"id": "C1418226", "name": "C1418226#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [17, 18]}}
{"token": ["C0001492#ent", "<e1>", "gonococci", "and", "staphylococci", "from", "patients", "with", "gonorrhoeae", "and", "C0034212#ent", "<e2>", "was", "studied", "ultracytochemically", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034212", "name": "C0034212#ent", "pos": [10, 11]}}
{"token": ["The", "C0079429#ent", "<e1>", ",", "designated", "as", "C3538771#ent", "<e2>", ",", "has", "an", "open", "reading", "frame", "of", "2154", "bp", ",", "a", "predicted", "718", "amino", "acid", "residues", "and", "exists", "as", "a", "single", "copy", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3538771", "name": "C3538771#ent", "pos": [6, 7]}}
{"token": ["Mutations", "of", "the", "bone", "morphogenetic", "protein", "BMP", ")", "receptor", "type", "II", "BMP-RII", ")", "C0079429#ent", "<e1>", "have", "been", "implicated", "in", "patients", "with", "familial", "and", "sporadic", "C3538771#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3538771", "name": "C3538771#ent", "pos": [24, 25]}}
{"token": ["Recent", "research", "groups", "identified", "the", "C0079429#ent", "<e1>", "responsible", "for", "familial", "C3538771#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538771", "name": "C3538771#ent", "pos": [10, 11]}}
{"token": ["The", "case", "illustrates", "that", "not", "all", "\"", "C0026113#ent", "<e1>", "\"", "chest", "radiograms", "Africa", "are", "tuberculous", "and", "a", "C1516468#ent", "<e2>", "not", "always", "diagnostic", "in", "individual", "cases", "of", "tuberculosis", "."], "h": {"id": "C0026113", "name": "C0026113#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516468", "name": "C1516468#ent", "pos": [17, 18]}}
{"token": ["The", "candidate", "genes", "of", "fibrosis", "were", "Spp1", ",", "C1413791#ent", "<e1>", ",", "and", "Cyp2c39", "and", "moreover", "C1538466#ent", "<e2>", "and", "Spp1", "were", "regarded", "as", "the", "candidate", "genes", "of", "carcinogenesis", "."], "h": {"id": "C1413791", "name": "C1413791#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538466", "name": "C1538466#ent", "pos": [15, 16]}}
{"token": ["Pseudomonas", "aeruginosa", "strain", "C3815532#ent", "<e1>", "was", "isolated", "on", "ethene", "as", "a", "sole", "C0524928#ent", "<e2>", "and", "energy", "source"], "h": {"id": "C3815532", "name": "C3815532#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [12, 13]}}
{"token": ["Proteomic", "responses", "methylotrophic", "yeasts", "(", "Hansenula", "polymorpha", "C3815532#ent", "<e1>", "and", "A16", ")", "to", "growth", "medium", "tuning", "by", "C0524928#ent", "<e2>", "source", "shift", "(", "glycerol-->methanol", ")", "were", "monitored", "and", "analyzed", "by", "two-dimensional", "gel", "electrophoresis"], "h": {"id": "C3815532", "name": "C3815532#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [17, 18]}}
{"token": ["An", "impression", "of", "the", "C0162671#ent", "<e1>", "favored", "because", "hearing", "loss", "part", "of", "the", "C0039082#ent", "<e2>", "for", "some", "patients", "with", "epilepsy", "."], "h": {"id": "C0162671", "name": "C0162671#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [13, 14]}}
{"token": ["We", "believe", "that", "C0162671#ent", "<e1>", "represents", "a", "distinctive", "C0039082#ent", "<e2>", "and", "that", "it", "can", "be", "differentiated", "from", "two", "other", "clinical", "disorders", "also", "are", "associated", "with", "mitochondrial", "myopathy", "cerebral", "disease", "Kearns-Sayre", "syndrome", "the", "myoclonus", "epilepsy", "ragged", "red", "fiber", "syndrome"], "h": {"id": "C0162671", "name": "C0162671#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}}
{"token": ["The", "phase", "II/III", "U.S.", "clinical", "drug", "trials", "for", "C0008783#ent", "<e1>", "(", "Tagamet", ")", "in", "C0013295#ent", "<e2>", "examined", "for", "their", "potential", "application", "to", "cost-benefit", "analysis"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [14, 15]}}
{"token": ["Both", "C0008783#ent", "<e1>", "and", "antacids", "produced", "a", "near", "elimination", "of", "C0013295#ent", "<e2>", "markedly", "reduced", "the", "severity", "of", "gastric", "disease", "compared", "to", "that", "of", "untreated", "historical", "controls", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [1, 2]}, "relation": "may_prevent", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [10, 11]}}
{"token": ["The", "B", "X", "SK", "is", "more", "like", "UK", "than", "SK", ",", "as", "an", "C1422492#ent", "<e1>", ",", "in", "activating", "non-human", "C1367553#ent", "<e2>"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [19, 20]}}
{"token": ["The", "Km", "value", "C1422492#ent", "<e1>", "for", "miniplasminogen", "is", "10", "times", "that", "of", "C1367553#ent", "<e2>", "20", "times", "that", "of", "plasminogen", "form", "II"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [12, 13]}}
{"token": ["The", "KLK6", "gene", "is", "a", "new", "member", "of", "the", "human", "C1416670#ent", "<e1>", "encodes", "for", "a", "secreted", "protease", ",", "C1449006#ent", "<e2>", "hK6", ";", "also", "known", "as", "zyme/protease", "M/neurosin", ")", "."], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1449006", "name": "C1449006#ent", "pos": [18, 19]}}
{"token": ["The", "normal", "epithelial", "cell-specific", "1", "(", "C1416670#ent", "<e1>", ")", "gene", "is", "a", "recently", "identified", "novel", "C1449006#ent", "<e2>", "is", "down-regulated", "during", "breast", "cancer", "progression", "."], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1449006", "name": "C1449006#ent", "pos": [15, 16]}}
{"token": ["The", "Epstein-Barr", "virus", "C0812384#ent", "<e1>", "LMP1", ")", "gene", "expression", "transactivated", "by", "EBV", "nuclear", "antigen", "2", "C3641847#ent", "<e2>", ")", "in", "human", "B", "cells"], "h": {"id": "C0812384", "name": "C0812384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3641847", "name": "C3641847#ent", "pos": [15, 16]}}
{"token": ["The", "Epstein-Barr", "virus", "EBV", ")", "C0812384#ent", "<e1>", "LMP1", ")", "gene", "expression", "transactivated", "by", "EBV", "nuclear", "antigen", "2", "C3641847#ent", "<e2>", ")", "in", "human", "B", "cells"], "h": {"id": "C0812384", "name": "C0812384#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3641847", "name": "C3641847#ent", "pos": [17, 18]}}
{"token": ["The", "order", "of", "apparent", "EC50", "values", "was", "C0242546#ent", "<e1>", "less", "than", "yohimbine", "less", "than", "phentolamine", "less", "than", "C0030071#ent", "<e2>", "less", "than", "prazosin", "less", "than", "AR-C", "239.7", "."], "h": {"id": "C0242546", "name": "C0242546#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030071", "name": "C0030071#ent", "pos": [17, 18]}}
{"token": ["The", "Christ-Siemens-Touraine", "syndrome", "C0162359#ent", "<e1>", "is", "the", "rare", "an-", "or", "C0020620#ent", "<e2>", "form", "of", "the", "ectodermal", "dysplasia"], "h": {"id": "C0162359", "name": "C0162359#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0020620", "name": "C0020620#ent", "pos": [10, 11]}}
{"token": ["It", "has", "been", "also", "found", "that", "efflux", "transporters", "Pgp", ",", "MRP1", "and", "C1412077#ent", "<e1>", "play", "roles", "in", "the", "absorption", "and", "excretion", "of", "green", "tea", "C0007404#ent", "<e2>", "."], "h": {"id": "C1412077", "name": "C1412077#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007404", "name": "C0007404#ent", "pos": [24, 25]}}
{"token": ["These", "results", "also", "indicate", "that", "C0669222#ent", "<e1>", "is", "a", "potent", "inhibitor", "of", "C0669372#ent", "<e2>", "expression", "by", "blocking", "the", "binding", "of", "NF-kappaB", "to", "promoter", "and", "exerts", "a", "beneficial", "effect", "in", "the", "mouse", "model", "sepsis", "."], "h": {"id": "C0669222", "name": "C0669222#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}}
{"token": ["For", "mixed", "generalized", "epilepsies", "as", "C0238111#ent", "<e1>", "juvenile", "myoclonic", "epilepsy", "zonisamide", "or", "C0076829#ent", "<e2>", "are", "the", "first-line", "agents"], "h": {"id": "C0238111", "name": "C0238111#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [12, 13]}}
{"token": ["Preliminary", "reports", "support", "the", "use", "of", "add-on", "C0076829#ent", "<e1>", "in", "adults", "with", "generalised", "epilepsy", "in", "childhood", "epilepsies", "in", "patients", "with", "C0238111#ent", "<e2>", "as", "well", "as", "the", "use", "of", "C0076829#ent", "<e1>", "monotherapy", "in", "patients", "with", "partial", "epilepsy"], "h": {"id": "C0238111", "name": "C0238111#ent", "pos": [20, 21]}, "relation": "may_be_treated_by", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [7, 8]}}
{"token": ["Each", "C0812325#ent", "<e1>", "retained", "in", "vivo", "incorporated", "in", "the", "C0017237#ent", "<e2>", "hydrogel", ":", "the", "smaller", "the", "in", "vitro", "desorption", "amount", "from", "the", "hydrogel", ",", "the", "longer", "the", "in", "vivo", "retention", "time", "."], "h": {"id": "C0812325", "name": "C0812325#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017237", "name": "C0017237#ent", "pos": [9, 10]}}
{"token": ["The", "elucidated", "pathological", "mechanisms", "of", "VZV-related", "C0030193#ent", "<e1>", "complications", "have", "provided", "the", "rationale", "for", "acute", "zoster", "pain", "C0043914#ent", "<e2>", ")", "and", "post-herpetic", "neuralgia", "PHN", ")", "treatment", "with", "antiviral", "therapy", "with", "neuroactive", "agents", "such", "as", "tricyclic", "or", "anticonvulsant", "agents"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0043914", "name": "C0043914#ent", "pos": [17, 18]}}
{"token": ["The", "latter", "could", "have", "some", "interest", "from", "the", "etiological", "point", "of", "view", "of", "certain", "C0030286#ent", "<e1>", "such", "as", "C0010674#ent", "<e2>", "pancreatitis", "."], "h": {"id": "C0030286", "name": "C0030286#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [18, 19]}}
{"token": ["Gene", "transfer", "technology", "a", "novel", "strategy", "for", "C0030286#ent", "<e1>", "as", "diabetes", ",", "pancreatitis", ",", "and", "C0010674#ent", "<e2>", "feasible", "but", "will", "benefit", "from", "continued", "approaches", "to", "limit", "toxicity", "."], "h": {"id": "C0030286", "name": "C0030286#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [15, 16]}}
{"token": ["This", "review", "discusses", "the", "functional", "studies", "of", "two", "C1832884#ent", "<e1>", "knockin", "mice", "and", "of", "several", "C1832884#ent", "<e1>", "mutants", "in", "heterologous", "expression", "systems", "12", "C1832884#ent", "<e1>", ",", "8", "FHM2", ",", "and", "1", "FHM3", ")", "."], "h": {"id": "C1832884", "name": "C1832884#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1832884", "name": "C1832884#ent", "pos": [8, 9]}}
{"token": ["The", "first", "step", "in", "erythroid", "heme", "biosynthesis", "catalyzed", "by", "a", "C1420295#ent", "<e1>", "isoform", "of", "5-aminolevulinate", "synthase", "C3812156#ent", "<e2>", ")", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3812156", "name": "C3812156#ent", "pos": [16, 17]}}
{"token": ["There", "are", "2", "C1420295#ent", "<e1>", "isoforms", "of", "C3812156#ent", "<e2>", ",", "erythroid-specific", "(", "ALAS-E", ")", "and", "nonspecific", "C3812156#ent", "<e2>", "(", "ALAS-N", ")", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3812156", "name": "C3812156#ent", "pos": [7, 8]}}
{"token": ["The", "effects", "of", "sympathetic", "denervation", "2", "weeks", "on", "vasoconstrictor", "reactivity", "to", "alpha-adrenoceptor", "agonists", "neuropeptide", "Y", "C1705518#ent", "<e1>", ")", "and", "alpha", ",", "beta-methylene", "adenosine", "triphosphate", "C4084746#ent", "<e2>", ")", "were", "investigated", "in", "different", "vascular", "compartments", "the", "nasal", "mucosa", "pentobarbital-anesthetized", "pigs", "."], "h": {"id": "C1705518", "name": "C1705518#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4084746", "name": "C4084746#ent", "pos": [24, 25]}}
{"token": ["Local", "intra-arterial", "injections", "of", "NA", ",", "C1705518#ent", "<e1>", "and", "the", "metabolically", "stable", "adenosine-5'-triphosphate", "analogue", "alpha", "beta-methylene", "ATP", "(", "C4084746#ent", "<e2>", ")", "caused", "reduction", "in", "both", "arterial", "blood", "flow", "nasal", "mucosal", "volume", "."], "h": {"id": "C1705518", "name": "C1705518#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4084746", "name": "C4084746#ent", "pos": [18, 19]}}
{"token": ["EFA", "deficiency", "demonstrated", "by", "analyzing", "the", "methyl", "esters", "the", "C0001175#ent", "<e1>", "the", "total", "lipid", "extract", "of", "C2931826#ent", "<e2>", "."], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2931826", "name": "C2931826#ent", "pos": [16, 17]}}
{"token": ["(+/-)-Terbutaline", "and", "C0015837#ent", "<e1>", "induced", "concentration-dependent", "relaxation", "of", "the", "precontracted", "gastric", "fundus", "C1826536#ent", "<e2>", "values", "of", "4.45+/-0.10", "and", "5.90+/-0.09", ",", "and", "intrinsic", "activities", "of", "1.00+/-0.03", "and", "0.99+/-0.01", "respectively", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826536", "name": "C1826536#ent", "pos": [12, 13]}}
{"token": ["In", "patients", "with", "PDR", "with", "vitreous", "hemorrhage", "C1420224#ent", "<e1>", ")", ",", "the", "mean", "C0271408#ent", "<e2>", "concentration", "of", "IL-6", "was", "significantly", "higher", "than", "that", "in", "PDR", "patients", "without", "C1420224#ent", "<e1>", "."], "h": {"id": "C1420224", "name": "C1420224#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0271408", "name": "C0271408#ent", "pos": [13, 14]}}
{"token": ["The", "average", "C1539428#ent", "<e1>", "score", "was", "higher", "in", "C0008373#ent", "<e2>", "42", "+", "/-", "9.4", "%", ")", "than", "in", "adult", "cholesteatoma", "(", "28.2", "+", "/-", "6", "%", ")", "."], "h": {"id": "C1539428", "name": "C1539428#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008373", "name": "C0008373#ent", "pos": [8, 9]}}
{"token": ["They", "promote", "cell", "migration", "C1504686#ent", "<e1>", "and", "heal", "the", "mucosa", "and", "may", "function", "as", "C0079427#ent", "<e2>", "."], "h": {"id": "C1504686", "name": "C1504686#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [14, 15]}}
{"token": ["Conversely", ",", "transfection", "of", "RKO", "cells", "with", "a", "transactivation", "domain-lacking", "C0812312#ent", "<e1>", "expression", "construct", "resulted", "in", "a", "dose-dependent", "decrease", "in", "C1706247#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706247", "name": "C1706247#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "the", "successful", "isolation", "and", "culture", "of", "human", "renal", "microvascular", "endothelial", "cells", "from", "both", "the", "glomerulus", "and", "C0041349#ent", "<e1>", "are", "paramount", "in", "studying", "C0022658#ent", "<e2>", "."], "h": {"id": "C0041349", "name": "C0041349#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [24, 25]}}
{"token": ["This", "would", "aggravate", "primary", "glomerular", "injury", "by", "compromising", "the", "vascular", "outflow", "the", "glomerulus", "and", "would", "account", "for", "the", "long-recognized", "association", "between", "C0041349#ent", "<e1>", "the", "progression", "of", "a", "variety", "of", "C0022658#ent", "<e2>"], "h": {"id": "C0041349", "name": "C0041349#ent", "pos": [21, 22]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [29, 30]}}
{"token": ["C1539600#ent", "<e1>", "has", "sequence", "homology", "with", "C3889695#ent", "<e2>", "in", "the", "middle", "and", "C-terminal", "regions", "but", "not", "in", "the", "N-terminal", "region", "."], "h": {"id": "C1539600", "name": "C1539600#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889695", "name": "C3889695#ent", "pos": [6, 7]}}
{"token": ["In", "human", "C0567085#ent", "<e1>", "or", "cervical", "cell", "cultures", "DES", "induces", "HOXA9", "or", "C1705270#ent", "<e2>", "gene", "expression", ",", "respectively", ",", "to", "levels", "approximately", "twofold", "that", "induced", "by", "estradiol", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705270", "name": "C1705270#ent", "pos": [12, 13]}}
{"token": ["The", "findings", "of", "this", "study", "indicate", "that", "preschool", "children", "with", "C0007789#ent", "<e1>", "be", "at", "high", "risk", "C0152027#ent", "<e2>", "which", "could", "markedly", "affect", "their", "hand", "function"], "h": {"id": "C0007789", "name": "C0007789#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0152027", "name": "C0152027#ent", "pos": [16, 17]}}
{"token": ["Two", "independent", "methionine", "catabolic", "pathways", "believed", "to", "be", "present", "in", "lactococci", ",", "one", "initiated", "by", "a", "C0024188#ent", "<e1>", "and", "the", "other", "initiated", "by", "an", "C0002594#ent", "<e2>", "."], "h": {"id": "C0024188", "name": "C0024188#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [24, 25]}}
{"token": ["In", "a", "single-blind", ",", "placebo-controlled", "study", "patients", "with", "C0010068#ent", "<e1>", "investigated", "the", "circadian", "anti-ischaemia", "and", "haemodynamic", "response", "interval", "therapy", "C0022252#ent", "<e2>", "120", "mg", "sustained", "release", "1", "X", "1", ")", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0022252", "name": "C0022252#ent", "pos": [19, 20]}}
{"token": ["The", "change", "in", "left", "ventricular", "volume", "a", "representative", "cardiac", "cycle", "assessed", "in", "19", "patients", "with", "C0010068#ent", "<e1>", "and", "8", "control", "subjects", "and", "after", "10", "mg", "C0022252#ent", "<e2>", "sublingually", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0022252", "name": "C0022252#ent", "pos": [25, 26]}}
{"token": ["Using", "C2987364#ent", "<e1>", "and", "mutant", "alleles", "of", "C1333572#ent", "<e2>", ",", "here", "we", "show", "that", "PGC-1alpha", "binds", "and", "co-activates", "C1333572#ent", "<e2>", "in", "a", "manner", "inhibited", "by", "Akt-mediated", "phosphorylation", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333572", "name": "C1333572#ent", "pos": [7, 8]}}
{"token": ["C0152068#ent", "<e1>", "a", "preventable", "C0043528#ent", "<e2>", "of", "human", "and", "veterinary", "public", "health", "in", "Tunisia", "."], "h": {"id": "C0152068", "name": "C0152068#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [4, 5]}}
{"token": ["A", "polymerase", "chain", "reaction", "PCR", ")", "using", "C1416775#ent", "<e1>", "BPAG1-specific", "primers", "produced", "amplified", "C0011519#ent", "<e2>", "with", "the", "predicted", "sizes", "in", "reverse-transcripted", "cDNA", "derived", "from", "keratinocyte", "and", "fibroblast", "RNA", "respectively", "."], "h": {"id": "C1416775", "name": "C1416775#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [13, 14]}}
{"token": ["To", "analyse", "QRS", "morphology", "in", "response", "to", "rapid", "atrial", "pacing", "C0079423#ent", "<e1>", ")", "and", "supraventricular", "tachycardia", "SVT", ")", "in", "patients", "with", "pre-existing", "C0006384#ent", "<e2>", "BBB", ")", "."], "h": {"id": "C0079423", "name": "C0079423#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006384", "name": "C0006384#ent", "pos": [22, 23]}}
{"token": ["Two", "presenilin", "(", "PS", ")", "C1334043#ent", "<e1>", ",", "referred", "to", "as", "C1418985#ent", "<e2>", "and", "PS2", ",", "comprise", "the", "catalytic", "core", "of", "gamma-secretase", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418985", "name": "C1418985#ent", "pos": [11, 12]}}
{"token": ["In", "particular", ",", "the", "procedure", "has", "consistently", "shown", "to", "result", "in", "the", "decreased", "risk", "of", "debilitating", "and", "costly", "diseases", "as", "C0019693#ent", "<e1>", ",", "cervical", "cancer", "and", "infantile", "C0042029#ent", "<e2>"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [27, 28]}}
{"token": ["C0282102#ent", "<e1>", "a", "rare", "C0015398#ent", "<e2>", "by", "punctate", "epiphyseal", "calcifications"], "h": {"id": "C0282102", "name": "C0282102#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015398", "name": "C0015398#ent", "pos": [4, 5]}}
{"token": ["Two", "new", "enzymatic", "activities", "of", "the", "species", "were", "defined", ":", "a", "C0031671#ent", "<e1>", "and", "a", "C1335226#ent", "<e2>", "PI-PLC", ")", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335226", "name": "C1335226#ent", "pos": [15, 16]}}
{"token": ["The", "terminal", "beta-N-acetylhexosamine", "of", "glycolipids", "such", "as", "globoside", "I", "C4283926#ent", "<e1>", ",", "and", "asialo", "C4283926#ent", "<e1>", "was", "cleaved", "by", "the", "ascidian", "beta-N-acetylhexosaminidase", "C4283926#ent", "<e1>", "was", "less", "susceptible", "to", "the", "C0027203#ent", "<e1>", "."], "h": {"id": "C4283926", "name": "C4283926#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [29, 30]}}
{"token": ["The", "authors", "suggest", "that", "the", "treatment", "modality", "depression", ",", "C0022806#ent", "<e1>", "and", "inflammation", "have", "an", "important", "role", "on", "QoL", "in", "C2974542#ent", "<e2>", "."], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2974542", "name": "C2974542#ent", "pos": [20, 21]}}
{"token": ["Infants", "manifest", "primarily", "C0268312#ent", "<e1>", "whereas", "adults", "manifest", "C2711227#ent", "<e2>", "early", "and", "C0268312#ent", "<e1>", "in", "the", "course", "of", "therapy", "."], "h": {"id": "C0268312", "name": "C0268312#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [8, 9]}}
{"token": ["We", "investigated", "adenosine", "deaminase", "C0001457#ent", "<e1>", ")", "deficient", "C0085110#ent", "<e2>", "SCID", ")", "in", "an", "8-month-old", "child", "with", "C0001457#ent", "<e1>", "deficient", "mother", "."], "h": {"id": "C0085110", "name": "C0085110#ent", "pos": [8, 9]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [4, 5]}}
{"token": ["Severe", "C0085110#ent", "<e1>", "SCID", ")", "due", "to", "adenosine", "deaminase", "C0001457#ent", "<e2>", ")", "deficiency", "is", "a", "fatal", "recessive", "disorder", "by", "mutations", "in", "the", "gene", "encoding", "C0001457#ent", "<e2>", "."], "h": {"id": "C0085110", "name": "C0085110#ent", "pos": [1, 2]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [9, 10]}}
{"token": ["Recently", ",", "OS", "was", "also", "identified", "in", "a", "growing", "list", "of", "other", "leaky", "C0085110#ent", "<e1>", "with", "mutations", "in", "RNA", "component", "of", "mitochondrial", "RNA", "processing", "endoribonuclease", "C0001457#ent", "<e2>", "IL-2", "receptor", "gamma", "IL-7", "receptor", "alpha", "ARTEMIS", ",", "and", "DNA", "ligase", "4"], "h": {"id": "C0085110", "name": "C0085110#ent", "pos": [13, 14]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [25, 26]}}
{"token": ["In", "this", "cell", "line", "the", "efficiency", "of", "C2314882#ent", "<e1>", "high", ",", "but", "the", "yield", "of", "C0042769#ent", "<e2>", "on", "the", "order", "of", "0.5", "%", "of", "that", "of", "3T3", "cells"], "h": {"id": "C2314882", "name": "C2314882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [15, 16]}}
{"token": ["The", "equivalent", "susceptibility", "of", "whole", "and", "adherent", "cell-depleted", "PBL", "to", "C2314882#ent", "<e1>", "the", "failure", "of", "hydrocortisone", "to", "enhance", "C0042769#ent", "<e2>", "compatible", "with", "identification", "of", "the", "FeLV-replicating", "cell", "as", "an", "lc", "."], "h": {"id": "C2314882", "name": "C2314882#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [18, 19]}}
{"token": ["C2314882#ent", "<e1>", "unequivocally", "proven", "by", "the", "detection", "of", "virion", "particles", "C0042769#ent", "<e2>", "trophoblast", "culture", "supernatant", "and", "cell-to-cell", "spread", "cytomegalovirus", "from", "infected", "trophoblasts", "to", "uninfected", "fibroblasts", "."], "h": {"id": "C2314882", "name": "C2314882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [10, 11]}}
{"token": ["A", "new", "C0289779#ent", "<e1>", "based", "ligand", "C0254374#ent", "<e2>", "was", "identified", ",", "which", "has", "near", "wild-type", "potency", "(", "EC(50)=0.54", "nM", ")", "to", "TRbeta(R320C", ")", "and", "TRbeta(R320H", ")", "."], "h": {"id": "C0289779", "name": "C0289779#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0254374", "name": "C0254374#ent", "pos": [6, 7]}}
{"token": ["These", "processes", "are", "affected", "by", "the", "alterations", "in", "vitamin", "D", "metabolism", "C0020502#ent", "<e1>", "that", "commonly", "occur", "with", "C0403447#ent", "<e2>"], "h": {"id": "C0020502", "name": "C0020502#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0403447", "name": "C0403447#ent", "pos": [17, 18]}}
{"token": ["C0020502#ent", "<e1>", "is", "recognized", "to", "be", "an", "invariable", "complication", "of", "C0403447#ent", "<e2>"], "h": {"id": "C0020502", "name": "C0020502#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0403447", "name": "C0403447#ent", "pos": [10, 11]}}
{"token": ["Tom22", "is", "a", "C1415740#ent", "<e1>", "is", "required", "for", "the", "higher-level", "organization", "of", "the", "C1826706#ent", "<e2>", "machinery", "."], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1826706", "name": "C1826706#ent", "pos": [13, 14]}}
{"token": ["This", "was", "confirmed", "by", "analysis", "of", "the", "cytoplasm", "C0427008#ent", "<e1>", "which", "decreased", "in", "the", "presence", "of", "C0054047#ent", "<e2>", "."], "h": {"id": "C0427008", "name": "C0427008#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0054047", "name": "C0054047#ent", "pos": [16, 17]}}
{"token": ["In", "accord", "with", "previous", "studies", "of", "others", ",", "C3469945#ent", "<e1>", "was", "required", "for", "C1426004#ent", "<e2>", "expression", "."], "h": {"id": "C3469945", "name": "C3469945#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1426004", "name": "C1426004#ent", "pos": [13, 14]}}
{"token": ["Since", "all", "of", "the", "components", "of", "the", "C1705504#ent", "<e1>", "complex", "are", "C1512488#ent", "<e2>", "to", "SWR1", "or", "NuA4", "subunits", ",", "we", "proposed", "that", "the", "human", "complex", "corresponds", "to", "a", "physical", "merge", "two", "yeast", "complexes"], "h": {"id": "C1705504", "name": "C1705504#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}}
{"token": ["Bcl-XL", ",", "which", "binds", "directly", "but", "weakly", "to", "the", "polytopic", "transmembrane", "region", "C1424489#ent", "<e1>", ",", "indirectly", "and", "cooperatively", "associates", "with", "the", "C1424489#ent", "<e1>", "cytosolic", "domain", "dependent", "on", "the", "presence", "of", "procaspase-8", "and", "C4284306#ent", "<e1>", "."], "h": {"id": "C1424489", "name": "C1424489#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4284306", "name": "C4284306#ent", "pos": [32, 33]}}
{"token": ["We", "have", "also", "shown", "that", "the", "combination", "of", "C0014485#ent", "<e1>", ",", "epigallocatechin", "and", "epigallocatechingallate", "with", "caffeine", ",", "C2698905#ent", "<e2>", "or", "theophylline", "induced", "cellular", "neutral", "endopeptidase", "activity"], "h": {"id": "C0014485", "name": "C0014485#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2698905", "name": "C2698905#ent", "pos": [17, 18]}}
{"token": ["Activation", "of", "C1709402#ent", "<e1>", "components", "occurs", "by", "PTEN", "loss", "and", "by", "C1332074#ent", "<e2>", "amplification", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332074", "name": "C1332074#ent", "pos": [11, 12]}}
{"token": ["TRPP2", "is", "thought", "to", "function", "with", "C1418599#ent", "<e1>", "integral", "protein-as", "part", "of", "a", "C0751283#ent", "<e2>", "in", "transducing", "Ca(2+)-dependent", "information", "."], "h": {"id": "C1418599", "name": "C1418599#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751283", "name": "C0751283#ent", "pos": [13, 14]}}
{"token": ["Asthma", "is", "a", "C1290886#ent", "<e1>", "by", "reversible", "bronchial", "constriction", "C0032285#ent", "<e2>", "airway", "remodeling"], "h": {"id": "C1290886", "name": "C1290886#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [9, 10]}}
{"token": ["Application", "of", "protein", "engineering", "to", "the", "redesign", "of", "the", "active", "site", "C0752243#ent", "<e1>", "has", "successfully", "generated", "an", "efficient", "peptide", "ligase", "C0763417#ent", "<e2>", "."], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0763417", "name": "C0763417#ent", "pos": [20, 21]}}
{"token": ["Two", "C0017337#ent", "<e1>", ",", "FRAXA", "and", "C1538691#ent", "<e2>", ",", "have", "been", "formally", "demonstrated", "to", "be", "responsible", "for", "POF", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538691", "name": "C1538691#ent", "pos": [6, 7]}}
{"token": ["Inhibitors", "of", "arachidonic", "acid", "metabolism", "C0389003#ent", "<e1>", "also", "prevented", "cell", "death", "that", "TRPV1", "C2987634#ent", "<e2>", "disrupted", "basal", "arachidonic", "acid", "and", "altered", "cyclo-oxygenase", "function", "a", "TRPV1-dependent", "mechanism", "in", "order", "to", "produce", "toxicity", "."], "h": {"id": "C0389003", "name": "C0389003#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "whether", "CLA", "acts", "as", "a", "C0389003#ent", "<e1>", "(", "COX", ")", "inhibitor", "or", "as", "an", "C2987634#ent", "<e2>", "of", "the", "peroxisome-proliferator-activator", "receptor", "PPAR", ")", "gamma", "in", "the", "ApoE(-/-", ")", "mouse", "model"], "h": {"id": "C0389003", "name": "C0389003#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [16, 17]}}
{"token": ["Chlorpheniramine", ",", "C0031507#ent", "<e1>", ",", "GABA", ",", "imipramine", ",", "meclizine", ",", "mescaline", ",", "C0947691#ent", "<e2>", ",", "and", "testosterone", "showed", "no", "or", "doubtful", "activity", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0947691", "name": "C0947691#ent", "pos": [13, 14]}}
{"token": ["Mebendazole", "and", "C0015821#ent", "<e1>", "appeared", "to", "be", "competitive", "inhibitors", "of", "C0009262#ent", "<e2>", "binding", "to", "bovine", "brain", "tubulin", "."], "h": {"id": "C0015821", "name": "C0015821#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [10, 11]}}
{"token": ["Oxibendazole", "and", "C0015821#ent", "<e1>", "were", "competitive", "inhibitors", "of", "C0009262#ent", "<e2>", "."], "h": {"id": "C0015821", "name": "C0015821#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "HDL", "activated", "MAP", "kinase", "PI3", "kinase", "and", "C1367798#ent", "<e1>", "inhibition", "fully", "attenuated", "C1328053#ent", "<e2>", "stimulation", "by", "HDL", "without", "affecting", "Akt", "or", "eNOS", "Ser-1179", "phosphorylation", "."], "h": {"id": "C1367798", "name": "C1367798#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [15, 16]}}
{"token": ["The", "incremental", "risk", "factors", "early", "infarction", "were", "related", "to", "incomplete", "revascularization", ",", "but", "late", "infarction", "related", "to", "lipid", "levels", "coexisting", "C0029896#ent", "<e1>", "(", "diabetes", ",", "positive", "family", "history", "and", "non-use", "of", "IMA", "to", "C0398738#ent", "<e2>", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0398738", "name": "C0398738#ent", "pos": [33, 34]}}
{"token": ["For", "comparison", ",", "1-[4-(5-", "maleimidopentyl)aminobenzyl]ethylenediamine-N", ",", "N", ",", "N',N'-tetraacetic", "acid", "(", "C0383927#ent", "<e1>", ")", "and", "meleimidoethyl", "3-[131I]iodohippurate", "(", "C0033223#ent", "<e2>", ")", "was", "coupled", "to", "OST7", "under", "the", "same", "conjunction", "chemistry", "."], "h": {"id": "C0383927", "name": "C0383927#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033223", "name": "C0033223#ent", "pos": [18, 19]}}
{"token": ["This", "effect", "was", "limited", "to", "atopic", "asthmatics", "in", "that", "in", "vitro", "cat", "allergen", "incubation", "for", "48", "h", "failed", "to", "significantly", "alter", "C1334899#ent", "<e1>", "binding", "affinity", "in", "C0282556#ent", "<e2>", ",", "atopic", "individuals", "."], "h": {"id": "C1334899", "name": "C1334899#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [26, 27]}}
{"token": ["The", "expression", "of", "the", "C1334899#ent", "<e1>", "GR", ")", "in", "untreated", "or", "in", "steroid-dependent", "C0282556#ent", "<e2>", "patients", "is", "poorly", "understood", "."], "h": {"id": "C1334899", "name": "C1334899#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [13, 14]}}
{"token": ["We", "reviewed", "the", "records", "of", "37", "patients", "with", "C0026896#ent", "<e1>", "treated", "with", "azathioprine", "(", "n", "=", "10", ")", "or", "C0010583#ent", "<e2>", "(", "n", "=", "27", ")", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [19, 20]}}
{"token": ["C0025029#ent", "<e1>", "reversed", "the", "phosphorylation", "levels", "of", "JNK", "and", "C0162508#ent", "<e2>", "as", "well", "as", "the", "expression", "of", "C0162508#ent", "<e2>", "caused", "by", "LK", "in", "a", "Western", "blot", "assay"], "h": {"id": "C0025029", "name": "C0025029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [9, 10]}}
{"token": ["By", "using", "expressed", "sequence", "tag", "walking", "together", "with", "the", "oligo-capping", "method", ",", "this", "gene", "was", "identified", "as", "C1368108#ent", "<e1>", "initially", "known", "as", "Pip5k2beta", "but", "now", "reclassified", "as", "C1335220#ent", "<e2>", ")", "."], "h": {"id": "C1368108", "name": "C1368108#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335220", "name": "C1335220#ent", "pos": [27, 28]}}
{"token": ["Dopaminergic", "neurotransmission", "been", "implicated", "in", "the", "motor", "activating", "induced", "by", "the", "local", "infusion", "of", "C0022614#ent", "<e1>", "in", "the", "ventral", "hippocampus", "C4284744#ent", "<e2>", ")", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4284744", "name": "C4284744#ent", "pos": [20, 21]}}
{"token": ["Simultaneous", "application", "of", "SCH", "23390", "C0022614#ent", "<e1>", "into", "the", "C4284744#ent", "<e2>", "attenuated", "the", "NMDA-evoked", "cFos", "expression", "in", "NAc", "shell"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4284744", "name": "C4284744#ent", "pos": [9, 10]}}
{"token": ["C1420423#ent", "<e1>", "is", "an", "RNA-processing-associated", "phosphoprotein", "so", "highly", "conserved", "that", "the", "C2002622#ent", "<e2>", "hLa", ")", "can", "replace", "the", "tRNA-processing", "function", "of", "the", "fission", "yeast", "La", "protein", "Sla1p", ")", "in", "vivo"], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2002622", "name": "C2002622#ent", "pos": [11, 12]}}
{"token": ["Three", "compounds", "reportedly", "blocking", "the", "N-methyl-D-aspartate", "(", "NMDA", ")", "receptor", ",", "namely", "2-amino-5-phosphonovalerate", ",", "gamma-D-glutamylglycine", "and", "C0047415#ent", "<e1>", "were", "injected", "subdurally", "onto", "the", "C0001614#ent", "<e2>", "of", "freely", "moving", "rats", "."], "h": {"id": "C0047415", "name": "C0047415#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [23, 24]}}
{"token": ["We", "suggest", "that", "C0010583#ent", "<e1>", "should", "be", "used", "as", "first", "line", "drug", "in", "difficult-to-treat", "C1704321#ent", "<e2>", "patients", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [14, 15]}}
{"token": ["Since", "C0010583#ent", "<e1>", "is", "often", "used", "for", "the", "treatment", "of", "C1704321#ent", "<e2>", "attention", "should", "be", "focused", "on", "the", "incidence", "of", "interstitial", "pneumonitis"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [10, 11]}}
{"token": ["C0017665#ent", "<e1>", "focal", "segmental", "glomerulosclerosis", "IgA", "nephropathy", "the", "most", "commonly", "recognized", "types", "of", "C0017658#ent", "<e2>", "progress", "to", "end-stage", "renal", "disease"], "h": {"id": "C0017665", "name": "C0017665#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [13, 14]}}
{"token": ["When", "nuclear", "uptake", "abrogated", ",", "small", "tagged", "C1527078#ent", "<e1>", "but", "not", "prothymosin", "alpha", "to", "C0005220#ent", "<e2>", ",", "accumulated", "significantly", "in", "the", "cytoplasm", "."], "h": {"id": "C1527078", "name": "C1527078#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [14, 15]}}
{"token": ["It", "was", "found", "that", "in", "patients", "affected", "by", "C1709246#ent", "<e1>", "lithiasis", "of", "the", "bile", "ways", ",", "C0947622#ent", "<e2>", "etc", ".", ")"], "h": {"id": "C1709246", "name": "C1709246#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [16, 17]}}
{"token": ["TNF-alpha", "is", "a", "proinflammatory", "cytokine", "involved", "in", "many", "inflammatory", "conditions", "as", "Crohn's", "disease", "rheumatoid", "arthritis", "C0006625#ent", "<e1>", ",", "AIDS", ",", "and", "C0026769#ent", "<e2>", "MS", ")", "."], "h": {"id": "C0006625", "name": "C0006625#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [21, 22]}}
{"token": ["TNF-alpha", "is", "a", "proinflammatory", "cytokine", "involved", "in", "many", "inflammatory", "conditions", "as", "Crohn's", "disease", "rheumatoid", "arthritis", "C0006625#ent", "<e1>", ",", "AIDS", ",", "and", "multiple", "sclerosis", "C0026769#ent", "<e2>", ")", "."], "h": {"id": "C0006625", "name": "C0006625#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [23, 24]}}
{"token": ["Platinum", "phases", "general", "formula", "Pt(n-", ")", ",", "M+", ",", "MX", "]", "can", "be", "electrogenerated", "from", "cathodic", "polarization", "in", "C0066373#ent", "<e1>", "a", "supporting", "C3536863#ent", "<e2>", ",", "MX", "."], "h": {"id": "C0066373", "name": "C0066373#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [22, 23]}}
{"token": ["Optimum", "capillary", "electrophoresis", "separation", "is", "obtained", "with", "ammonium", "acetate", "25", "mM", ")", "dissolved", "in", "C0066373#ent", "<e1>", "(", "90:10", ")", "as", "background", "C3536863#ent", "<e2>", "."], "h": {"id": "C0066373", "name": "C0066373#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [21, 22]}}
{"token": ["Finally", ",", "BCR-ABL(T315I", ")", "mutations", "remain", "a", "new", "therapeutic", "critical", "challenge", "as", "none", "of", "the", "three", "TKIs", "(", "imatinib", ",", "C1721377#ent", "<e1>", ",", "dasatinib", ")", "can", "efficiently", "control", "such", "C0029896#ent", "<e2>", "."], "h": {"id": "C1721377", "name": "C1721377#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [29, 30]}}
{"token": ["Angelica", "dahurica", "Umbelliferae", ")", "has", "been", "used", "to", "treat", "headache", "of", "common", "cold", ",", "supraorbital", "neuralgia", "C0030193#ent", "<e1>", "the", "body", ",", "nasal", "stuffiness", "C0023533#ent", "<e2>", "and", "arthralgia", "due", "to", "wind-dampness", "in", "Korean", "traditional", "medicine", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023533", "name": "C0023533#ent", "pos": [23, 24]}}
{"token": ["Pharmacological", "and", "genetic", "modulation", "cannabinoid", "receptors", "that", "C2347556#ent", "<e1>", "provide", "attractive", "and", "novel", "agents", "for", "the", "treatment", "of", "C0005940#ent", "<e2>"], "h": {"id": "C2347556", "name": "C2347556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [18, 19]}}
{"token": ["Through", "their", "ability", "to", "scavenge", "C0812281#ent", "<e1>", "and", "reduce", "oxidative", "DNA", "damage", "stimulate", "antioxidant", "enzymes", "inhibit", "carcinogen-induced", "DNA", "adduct", "formation", "enhance", "C1333237#ent", "<e2>", "berry", "compounds", "been", "shown", "to", "inhibit", "mutagenesis", "and", "cancer", "initiation"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "IL-6", "and", "C1334103#ent", "<e1>", "production", "levels", "in", "response", "to", "IgE", "were", "reduced", "by", "C1705644#ent", "<e2>", ",", "whereas", "that", "of", "TNF-alpha", "was", "up-regulated", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705644", "name": "C1705644#ent", "pos": [16, 17]}}
{"token": ["The", "association", "with", "C0152026#ent", "<e1>", "nephropathy", ",", "meningo-encephalitis", ",", "cerebral", "vasculitis", "and", "thyroiditis", "suggests", "that", "C0154884#ent", "<e2>", "may", "be", "one", "manifestation", "of", "a", "diffuse", "systemic", "condition", "."], "h": {"id": "C0152026", "name": "C0152026#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0154884", "name": "C0154884#ent", "pos": [15, 16]}}
{"token": ["This", "case", "gives", "support", "to", "the", "theory", "of", "C0152026#ent", "<e1>", "a", "cause", "of", "C0154884#ent", "<e2>", "."], "h": {"id": "C0152026", "name": "C0152026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0154884", "name": "C0154884#ent", "pos": [13, 14]}}
{"token": ["Inhibition", "of", "C0033681#ent", "<e1>", "phosphorylation", "using", "genistein", "had", "no", "effect", "IP3", "or", "C1413902#ent", "<e2>", "generation", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413902", "name": "C1413902#ent", "pos": [12, 13]}}
{"token": ["The", "other", "patient", "was", "continued", "on", "risperidone", "due", "to", "a", "robust", "response", ",", "while", "her", "C3665358#ent", "<e1>", "was", "partially", "treated", "with", "C0006230#ent", "<e2>", "."], "h": {"id": "C3665358", "name": "C3665358#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [21, 22]}}
{"token": ["Fifteen", "patients", "with", "C3665358#ent", "<e1>", "studied", "before", ",", "during", ",", "and", "after", "treatment", "with", "C0006230#ent", "<e2>", "."], "h": {"id": "C3665358", "name": "C3665358#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [14, 15]}}
{"token": ["To", "test", "whether", "the", "absence", "of", "PN-1", "in", "Schwann", "cells", "in", "the", "axon", "caused", "delay", "in", "reinnervation", ",", "PN-1", "was", "C3889446#ent", "<e1>", "exclusively", "in", "the", "nerves", "of", "PN-1", "C4284124#ent", "<e2>", "mice", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [28, 29]}}
{"token": ["We", "investigated", "the", "effect", "of", "C0066700#ent", "<e1>", "mucociliary", "clearance", "in", "patients", "with", "C0035457#ent", "<e2>"], "h": {"id": "C0066700", "name": "C0066700#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [12, 13]}}
{"token": ["ESA1", ",", "SAS3", ",", "MOF", ",", "TIP60", ",", "C1424687#ent", "<e1>", ",", "MOZ", ",", "and", "MORF", "are", "the", "C2825102#ent", "<e2>", "family", "members", "demonstrated", "HAT", "activity", "."], "h": {"id": "C1424687", "name": "C1424687#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2825102", "name": "C2825102#ent", "pos": [17, 18]}}
{"token": ["C1424687#ent", "<e1>", "belongs", "to", "the", "C2825102#ent", "<e2>", "family", ",", "characterized", "by", "a", "highly", "conserved", "C2HC", "zinc", "finger", "a", "putative", "histone", "acetyltransferase", "domain"], "h": {"id": "C1424687", "name": "C1424687#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2825102", "name": "C2825102#ent", "pos": [5, 6]}}
{"token": ["C1424687#ent", "<e1>", "belongs", "to", "the", "C2825102#ent", "<e2>", "family", ",", "which", "is", "characterized", "by", "a", "highly", "conserved", "C2HC", "zinc", "finger", "a", "putative", "histone", "acetyltransferase", "domain"], "h": {"id": "C1424687", "name": "C1424687#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2825102", "name": "C2825102#ent", "pos": [5, 6]}}
{"token": ["Over", "a", "25-minute", "period", "before", "transportation", "to", "the", "veterinary", "hospital", "the", "animal", "received", "a", "total", "dose", "1.225", "mg", "C0015134#ent", "<e1>", ",", "30", "mg", "acepromazine", "and", "30", "mg", "C0125656#ent", "<e2>", "."], "h": {"id": "C0015134", "name": "C0015134#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0125656", "name": "C0125656#ent", "pos": [27, 28]}}
{"token": ["These", "findings", "suggest", "that", "C0001047#ent", "<e1>", "may", "be", "beneficial", "in", "clinical", "conditions", "like", "C0010674#ent", "<e2>", "where", "tissue", "damage", "be", "a", "consequence", "of", "the", "effects", "of", "increased", "release", "of", "toxic", "oxygen", "radicals", "proteolytic", "enzymes"], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "peroral", "C0001047#ent", "<e1>", "(", "NAC", ")", "in", "patients", "with", "C0010674#ent", "<e2>", "CF", ")", "and", "primary", "ciliary", "dyskinesia", "PCD", ")", "was", "investigated", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [12, 13]}}
{"token": ["Emerging", "evidence", "suggests", "that", "the", "vagal", "and", "neurohormonal", "output", "of", "the", "gut", "during", "feeding", "promotes", "C1423842#ent", "<e1>", "function", ",", "which", "is", "desirable", "in", "fighting", "C0162628#ent", "<e2>"], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [24, 25]}}
{"token": ["Inhibition", "of", "C1335654#ent", "<e1>", "activity", "with", "the", "CBFbeta-SMMHC", "or", "AML1-ETO", "oncoproteins", "reduced", "C0173532#ent", "<e2>", "expression", ",", "and", "C1335654#ent", "<e1>", "bound", "and", "activated", "the", "cyclin", "D3", "promoter", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0173532", "name": "C0173532#ent", "pos": [12, 13]}}
{"token": ["Despite", "a", "clinical", "loading", "dose", "routine", "with", "C0070166#ent", "<e1>", ",", "some", "patients", "still", "experience", "C0010072#ent", "<e2>", "persistent", "platelet", "activation"], "h": {"id": "C0070166", "name": "C0070166#ent", "pos": [7, 8]}, "relation": "may_prevent", "t": {"id": "C0010072", "name": "C0010072#ent", "pos": [14, 15]}}
{"token": ["Mutations", "in", "the", "human", "GnRH", "receptor", "C1415171#ent", "<e1>", ")", "gene", "have", "been", "reported", "in", "families", "with", "C0022735#ent", "<e2>"], "h": {"id": "C1415171", "name": "C1415171#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0022735", "name": "C0022735#ent", "pos": [16, 17]}}
{"token": ["Fourteen", "mutations", "(", "13", "missense", "and", "1", "truncation", ")", "of", "the", "GnRH", "receptor", "C1415171#ent", "<e1>", ")", "have", "been", "identified", "in", "patients", "with", "C0022735#ent", "<e2>", "HH", ")", "."], "h": {"id": "C1415171", "name": "C1415171#ent", "pos": [13, 14]}, "relation": "gene_associated_with_disease", "t": {"id": "C0022735", "name": "C0022735#ent", "pos": [22, 23]}}
{"token": ["Epilepsy", "is", "a", "C1561643#ent", "<e1>", "requires", "long", "term", "therapy", "and", "most", "of", "the", "established", "C0003299#ent", "<e2>", "the", "exception", "is", "phenobarbital", ")", "must", "be", "administered", "several", "times", "daily", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [14, 15]}}
{"token": ["According", "to", "several", "experimental", "studies", "antineutrophil", "cytoplasmic", "antibodies", "ANCA", ")", "are", "involved", "in", "the", "pathogenesis", "of", "tissue", "injury", "some", "systemic", "vasculitis", "C0017658#ent", "<e1>", "by", "stimulating", "oxygen", "radical", "release", "secretion", "of", "C0391845#ent", "<e2>", "neutrophilic", "granulocytes"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [30, 31]}}
{"token": ["The", "polymeric", "immunoglobulin", "receptor", "normally", "delivered", "from", "the", "C1423498#ent", "<e1>", "to", "the", "basolateral", "surface", "of", "epithelial", "cells", "then", "transports", "C0071610#ent", "<e2>", "IgM", "to", "the", "apical", "surface", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0071610", "name": "C0071610#ent", "pos": [19, 20]}}
{"token": ["C1705742#ent", "<e1>", "is", "similar", "to", "ATP-dependent", ",", "chromatin-remodeling", "proteins", "the", "C1335844#ent", "<e2>", "and", "SWI2/SNF2", "family"], "h": {"id": "C1705742", "name": "C1705742#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335844", "name": "C1335844#ent", "pos": [10, 11]}}
{"token": ["Although", "the", "clinical", "picture", "C0014118#ent", "<e1>", "produced", "by", "E.", "rhusiopathiae", "indistinguishable", "from", "other", "forms", "of", "C0014122#ent", "<e2>", "this", "infection", "has", "a", "mortality", "rate", "40", "%", "and", "a", "high", "morbidity"], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [15, 16]}}
{"token": ["The", "increase", "in", "TNF-R75", "release", "was", "related", "to", "the", "activity", "of", "C0014118#ent", "<e1>", "since", "TNF-R75", "release", "was", "similar", "in", "patients", "with", "cured", "C0014122#ent", "<e2>", "and", "controls", "."], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [22, 23]}}
{"token": ["Two", "different", "clinical", "endocarditis", "entities", "can", "be", "separated", ":", "an", "acute", "aggressive", "course", "C0014118#ent", "<e1>", "and", "the", "subacute", "course", "C0014122#ent", "<e2>", "."], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [19, 20]}}
{"token": ["C1424288#ent", "<e1>", "completely", "converts", "C0244656#ent", "<e2>", "to", "phenytoin", "in", "5", "minutes", "."], "h": {"id": "C1424288", "name": "C1424288#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0244656", "name": "C0244656#ent", "pos": [4, 5]}}
{"token": ["C3272408#ent", "<e1>", "and", "Cp-1", "are", "lytic", "phages", ",", "whereas", "C1825770#ent", "<e2>", "and", "EJ-1", "are", "temperate", "phages", "."], "h": {"id": "C3272408", "name": "C3272408#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1825770", "name": "C1825770#ent", "pos": [9, 10]}}
{"token": ["The", "genes", "encoding", "DnaK", ",", "C1428391#ent", "<e1>", "and", "GrpE", "of", "V.", "harveyi", "were", "cloned", "into", "expression", "vectors", "C1426341#ent", "<e2>", "was", "sequenced", "."], "h": {"id": "C1428391", "name": "C1428391#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1426341", "name": "C1426341#ent", "pos": [17, 18]}}
{"token": ["The", "B", "lymphocyte-induced", "maturation", "protein", "Blimp-1", ")", "upregulates", "the", "expression", "of", "syndecan-1", "and", "C1416161#ent", "<e1>", "represses", "that", "of", "C0086661#ent", "<e2>", "."], "h": {"id": "C1416161", "name": "C1416161#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [18, 19]}}
{"token": ["This", "case", "suggests", "that", "lack", "of", "immune", "deficiency", "not", "exclude", "the", "possibility", "of", "C0023524#ent", "<e1>", "as", "a", "cause", "of", "C0270612#ent", "<e2>"], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0270612", "name": "C0270612#ent", "pos": [19, 20]}}
{"token": ["In", "both", "cases", ",", "unique", "chromatin", "configurations", "appear", "to", "be", "orchestrated", "by", "multiprotein", "complexes", "to", "particular", "regions", "through", "interactions", "with", "specific", "C0812382#ent", "<e1>", "such", "as", "C3814146#ent", "<e2>", ",", "the", "origin-recognition", "complex", "and", "alpha", "2"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3814146", "name": "C3814146#ent", "pos": [25, 26]}}
{"token": ["The", "average", "level", "of", "C0812204#ent", "<e1>", ",", "but", "not", "C1332751#ent", "<e2>", ",", "mRNA", "expression", "was", "statistically", "higher", "metastatic", "biopsies", "compared", "with", "primary", "tumour", "biopsies", "."], "h": {"id": "C0812204", "name": "C0812204#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332751", "name": "C1332751#ent", "pos": [9, 10]}}
{"token": ["We", "obtained", "a", "hen", "antibody", "that", "specifically", "reacts", "with", "C0812204#ent", "<e1>", "without", "any", "cross-reaction", "with", "C1332751#ent", "<e2>", "."], "h": {"id": "C0812204", "name": "C0812204#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332751", "name": "C1332751#ent", "pos": [15, 16]}}
{"token": ["In", "spite", "of", "a", "cumbersome", "and", "intrusive", "type", "of", "treatment", ",", "patients", "under", "home", "mechanical", "ventilation", "predominantly", "restrictive", "C0024115#ent", "<e1>", "found", "to", "have", "a", "better", "quality", "of", "life", "C0024117#ent", "<e2>", "patients", "under", "conservative", "therapy"], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [28, 29]}}
{"token": ["Complete", "and", "partial", "objective", "responses", "were", "achieved", "in", "23.5", "%", "of", "the", "C1417487#ent", "<e1>", "group", "and", "28.6", "%", "of", "the", "C0796074#ent", "<e2>", "group", "(", "P", "=", "0.51", ")", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [20, 21]}}
{"token": ["Median", "survival", "patients", "was", "6.1", "months", "with", "C1417487#ent", "<e1>", "and", "6.3", "months", "with", "C0796074#ent", "<e2>", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [13, 14]}}
{"token": ["Median", "duration", "of", "response", "was", "84", "days", "in", "the", "C1417487#ent", "<e1>", "group", "and", "92", "days", "in", "the", "C0796074#ent", "<e2>", "group", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [17, 18]}}
{"token": ["A", "prospective", "randomized", "study", "conducted", "to", "determine", "the", "relative", "effectiveness", ",", "toxicity", "and", "tolerance", "of", "methotrexate", "(", "C1417487#ent", "<e1>", ")", "versus", "cisplatin", "(", "C0796074#ent", "<e2>", ")", "in", "patients", "with", "recurrent", "head", "and", "neck", "squamous", "cell", "carcinoma"], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [23, 24]}}
{"token": ["In", "cells", "incubated", "with", "glucose", ",", "C0376261#ent", "<e1>", ",", "or", "dihydroxyacetone", "the", "effect", "of", "glutamine", "and", "C0165463#ent", "<e2>", "was", "synergistic", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0165463", "name": "C0165463#ent", "pos": [16, 17]}}
{"token": ["Staphylococcal", "exfoliative", "toxin", "ET", ")", "is", "an", "extracellular", "product", "Staphylococcus", "aureus", "isolated", "from", "patients", "with", "staphylococcal", "scalded", "skin", "syndrome", "C0723181#ent", "<e1>", ")", "which", "includes", "Ritter's", "disease", "C0021099#ent", "<e2>", "staphylococcal", "scarlet", "fever", "and", "has", "been", "regarded", "as", "the", "causative", "agent", "C0723181#ent", "<e1>", "."], "h": {"id": "C0021099", "name": "C0021099#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0723181", "name": "C0723181#ent", "pos": [19, 20]}}
{"token": ["C0723181#ent", "<e1>", "encompasses", "a", "clinical", "spectrum", "C0021099#ent", "<e2>", "the", "widespread", "exfoliation", "of", "the", "Ritter", "disease", "variant", "C0723181#ent", "<e1>", "."], "h": {"id": "C0021099", "name": "C0021099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0723181", "name": "C0723181#ent", "pos": [0, 1]}}
{"token": ["We", "studied", "the", "effects", "of", "C0053398#ent", "<e1>", "(", "beta-CMs", ",", "mu-acting", "opioid", "peptides", "from", "C0007332#ent", "<e2>", "on", "survival", "of", "primary-cultured", "chick", "dorsal", "root", "ganglion", "neurons", "in", "the", "presence", "of", "nerve", "growth", "factor"], "h": {"id": "C0053398", "name": "C0053398#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [14, 15]}}
{"token": ["C0068700#ent", "<e1>", "pretreatment", "significantly", "decreased", "the", "incidence", "and", "C2926735#ent", "<e2>", "of", "reperfusion-induced", "life-threatening", "arrhythmias", "and", "increased", "the", "number", "of", "animals", "that", "survived", "without", "developing", "any", "arrhythmia", "."], "h": {"id": "C0068700", "name": "C0068700#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [8, 9]}}
{"token": ["Compared", "with", "placebo", ",", "20", "mg", "of", "C0068700#ent", "<e1>", "significantly", "increased", "maximal", "exercise", "C2926735#ent", "<e2>", "and", "time", "to", "1", "mm", "of", "ST-segment", "depression", "1", ",", "3", ",", "and", "6", "h", "after", "administration", "."], "h": {"id": "C0068700", "name": "C0068700#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [13, 14]}}
{"token": ["CT", "has", "detected", "C0041296#ent", "<e1>", "of", "the", "intrathoracic", "lymph", "nodes", "C4084734#ent", "<e2>", ")", "in", "28(37.3", "%", ")", "children", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4084734", "name": "C4084734#ent", "pos": [10, 11]}}
{"token": ["Thromboembolism", "is", "considered", "the", "inciting", "cause", "of", "many", "C0042373#ent", "<e1>", "acute", "coronary", "syndrome", "ACS", ")", ",", "ischemic", "stroke", "pulmonary", "embolism", "PE", ")", ",", "C0149871#ent", "<e2>", "DVT", ")", ",", "and", "mesenteric", "ischemia"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [23, 24]}}
{"token": ["We", "have", "recently", "reported", "the", "existence", "of", "ATPase", "activity", "of", "C0033993#ent", "<e1>", "extracellular", "ATP", "and", "localized", "at", "the", "external", "cell", "membrane", "goldfish", "C0669372#ent", "<e2>", "[", "Am", "."], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [22, 23]}}
{"token": ["With", "the", "use", "of", "a", "heterologous", "expression", "system", "we", "show", "that", ",", "like", "C1421567#ent", "<e1>", ",", "Syk", "is", "dependent", "upon", "a", "C0282625#ent", "<e2>", "association", "with", "the", "phosphorylated", "zeta-chain", "."], "h": {"id": "C1421567", "name": "C1421567#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [21, 22]}}
{"token": ["The", "induction", "of", "anesthesia", "was", "started", "with", "C0059489#ent", "<e1>", "30", "mg", "iv", "and", "C0039925#ent", "<e2>", "4", "mg.kg-1", "iv", "and", "the", "trachea", "was", "intubated", "smoothly", "following", "succinylcholine", "40", "mg", "iv", "."], "h": {"id": "C0059489", "name": "C0059489#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [13, 14]}}
{"token": ["They", "are", "often", "recognized", "by", "elevated", "incidence", "of", "certain", "C0852077#ent", "<e1>", "observed", "in", "regions", "of", "C0795950#ent", "<e2>", "and", "Saguenay-Lac-Saint-Jean", "(", "SLSJ", ")", "in", "Northeastern", "Quebec"], "h": {"id": "C0852077", "name": "C0852077#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0795950", "name": "C0795950#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "both", "dynamin2", "K44A", "and", "C1419212#ent", "<e1>", "S34N", "mildly", "inhibited", "LPA1-dependent", "activation", "of", "C1420400#ent", "<e2>"], "h": {"id": "C1419212", "name": "C1419212#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420400", "name": "C1420400#ent", "pos": [15, 16]}}
{"token": ["The", "combination", "C0297635#ent", "<e1>", "and", "C0041023#ent", "<e2>", "is", "more", "effective", "than", "C0297635#ent", "<e1>", "alone", "."], "h": {"id": "C0041023", "name": "C0041023#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0297635", "name": "C0297635#ent", "pos": [2, 3]}}
{"token": ["Electromyographical", "analyses", "pre-symptomatic", "motor", "unit", "in", "the", "C1420306#ent", "<e1>", "G93A", "transgenic", "mouse", "model", "of", "C0002736#ent", "<e2>", "ALS", ")", "have", "yielded", "contradictory", "findings", "as", "to", "the", "onset", "and", "time", "course"], "h": {"id": "C1420306", "name": "C1420306#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [14, 15]}}
{"token": ["C0011685#ent", "<e1>", "more", "often", "produced", "dry", "mouth", "constipation", "and", "C0027769#ent", "<e2>", ",", "while", "adinazolam", "was", "more", "likely", "to", "cause", "drowsiness", "and", "lightheadedness", "."], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027769", "name": "C0027769#ent", "pos": [9, 10]}}
{"token": ["Immunostaining", "was", "negative", "for", "all", "the", "classical", "antibodies", "(", "cytokeratins", ",", "C3812647#ent", "<e1>", ",", "lymphoid", "markers", ",", "but", "all", "the", "cases", "expressed", "C1416655#ent", "<e2>", "(", "100", "%", ")", "."], "h": {"id": "C3812647", "name": "C3812647#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [22, 23]}}
{"token": ["The", "erythrocyte", "indices", "C1415478#ent", "<e1>", "levels", "in", "patients", "classified", "as", "C0002312#ent", "<e2>", ",", "by", "either", "globin", "synthesis", "or", "gene", "mapping", "were", "very", "similar", "to", "those", "previously", "reported", "by", "others", "."], "h": {"id": "C1415478", "name": "C1415478#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002312", "name": "C0002312#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "C0286088#ent", "<e1>", "is", "a", "surmountable", "antagonist", "of", "vascular", "but", "not", "tubular", "C1417815#ent", "<e2>", "effects", "."], "h": {"id": "C0286088", "name": "C0286088#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [13, 14]}}
{"token": ["We", "report", "the", "occurrence", "of", "severe", "C3854173#ent", "<e1>", "a", "10-year-old", "girl", "with", "C3714757#ent", "<e2>", "1", "month", "of", "naproxen", "therapy"], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [12, 13]}}
{"token": ["The", "cellular", "death", "by", "the", "administration", "of", "C1134446#ent", "<e1>", "was", "partially", "reversed", "by", "the", "addition", "of", "C0383779#ent", "<e2>", ",", "a", "caspase", "family", "inhibitor"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0383779", "name": "C0383779#ent", "pos": [16, 17]}}
{"token": ["Intal", "drops", "(", "C0012694#ent", "<e1>", "relieved", "symptoms", "of", "C0009763#ent", "<e2>", "all", "the", "19", "patients", "we", "studied", ",", "reducing", "the", "need", "for", "steroids", "although", "the", "response", "varied", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [8, 9]}}
{"token": ["To", "observe", "the", "clinical", "effect", "alomide", "and", "C0012694#ent", "<e1>", "the", "treatment", "of", "atopic", "conjunctivitis", "C0009763#ent", "<e2>", "giant", "papillary", "conjunctivitis"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "study", "we", "investigated", "C3539616#ent", "<e1>", "responses", "to", "GHB", "with", "or", "without", "naloxone", "(", "an", "C1516869#ent", "<e2>", "or", "metergoline", "(", "a", "serotonin", "receptor", "antagonist", "pretreatment", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [17, 18]}}
{"token": ["This", "review", "provides", "an", "overview", "of", "C3539616#ent", "<e1>", "and", "the", "GH/insulin-like", "growth", "factor", "IGF-1", ")", "axis", "and", "highlights", "a", "C1516869#ent", "<e2>", "i.e.", "Somavert(R", ")", ",", "pegvisomant", ")", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [19, 20]}}
{"token": ["C0019154#ent", "<e1>", "EHPVT", ")", "is", "associated", "with", "abnormal", "circulating", "C0009117#ent", "<e2>", "and", "anticoagulants", "."], "h": {"id": "C0019154", "name": "C0019154#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009117", "name": "C0009117#ent", "pos": [9, 10]}}
{"token": ["In", "C0302809#ent", "<e1>", "liver", "failure", "brain", "edema", "progress", "to", "C0151740#ent", "<e2>"], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [9, 10]}}
{"token": ["We", "report", "a", "fatal", "case", "of", "C0302809#ent", "<e1>", "cryptococcaemia", "culminating", "in", "severe", "C0151740#ent", "<e2>", "to", "C.", "gattii"], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [12, 13]}}
{"token": ["The", "sequences", "representing", "20", "%", "of", "the", "primary", "structure", "alpha-clostripain", "are", "not", "homologous", "with", "either", "other", "C2717970#ent", "<e1>", "with", "any", "other", "C1510464#ent", "<e2>", "to", "date", "."], "h": {"id": "C2717970", "name": "C2717970#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1510464", "name": "C1510464#ent", "pos": [21, 22]}}
{"token": ["C0031653#ent", "<e1>", "shows", "clinial", "variation", "north", "of", "Cape", "Cod", "two", "of", "the", "three", "C0002085#ent", "<e2>", ",", "while", "the", "two", "leucine", "aminopeptidase", "loci", "not", "clinial", "."], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [13, 14]}}
{"token": ["Although", "there", "is", "limited", "clinical", "data", "the", "effectiveness", "of", "echinocandins", "in", "pediatric", "patients", "with", "documented", "invasive", "C0026946#ent", "<e1>", "this", "case", "report", "that", "combining", "liposomal", "amphotericin", "B", "C0935942#ent", "<e2>", "could", "be", "advantageous", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0935942", "name": "C0935942#ent", "pos": [26, 27]}}
{"token": ["C1335268#ent", "<e1>", "is", "the", "dominant", "binding", "partner", "of", "C0917728#ent", "<e2>", "IN", ")", "in", "human", "cells"], "h": {"id": "C1335268", "name": "C1335268#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0917728", "name": "C0917728#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "this", "study", "indicates", "that", "polymorphisms", "in", "the", "3'UTR", "and", "the", "5'URR", "of", "the", "C3538699#ent", "<e1>", "influence", "the", "expression", "of", "C1415587#ent", "<e2>", "of", "possible", "importance", "in", "pathological", "pregnancies", "also", "in", "organ", "transplantation"], "h": {"id": "C3538699", "name": "C3538699#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415587", "name": "C1415587#ent", "pos": [22, 23]}}
{"token": ["Treatment", "of", "BLMVECs", "with", "4-HNE", "resulted", "in", "the", "redistribution", "of", "C0059239#ent", "<e1>", ",", "paxillin", ",", "VE-cadherin", ",", "beta-catenin", ",", "and", "C1420744#ent", "<e2>", ",", "and", "intercellular", "gap", "formation"], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420744", "name": "C1420744#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "suggest", "potential", "roles", "of", "C1825346#ent", "<e1>", ",", "adiponectin", ",", "and", "IL-18", "in", "the", "pathogenesis", "of", "C0005944#ent", "<e2>", "HIV-infected", "patients", "."], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [17, 18]}}
{"token": ["Pretreatment", "with", "a", "prostacyclin", "analog", "beraprost", ")", ",", "a", "C3536754#ent", "<e1>", "lansoprazole", ")", "or", "a", "histamine", "H2", "receptor", "antagonist", "C0015620#ent", "<e2>", ")", "prevented", "formation", "of", "gastric", "mucosal", "erosion", "while", "only", "the", "prostacyclin", "analog", "inhibited", "expression", "of", "IEGs", "."], "h": {"id": "C3536754", "name": "C3536754#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015620", "name": "C0015620#ent", "pos": [19, 20]}}
{"token": ["C2316159#ent", "<e1>", "represented", "by", "mostly", "C1457887#ent", "<e2>", "oral", "cavity", "usually", "triggered", "by", "fruit", "or", "vegetable", "allergens", "cross-reacting", "with", "pollen", "allergens", "."], "h": {"id": "C2316159", "name": "C2316159#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [5, 6]}}
{"token": ["Metabolic", "abnormalities", "associated", "with", "metabolic", "syndrome", "also", "present", "in", "patients", "with", "C0011860#ent", "<e1>", "in", "those", "with", "familial", "combined", "hyperlipidemia", "C1706445#ent", "<e2>", ")", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706445", "name": "C1706445#ent", "pos": [19, 20]}}
{"token": ["In", "3T3-L1", "adipocytes", ",", "C0008163#ent", "<e1>", "binds", "to", "Fyn", "in", "an", "C0011854#ent", "<e2>", "manner", ",", "and", "C0008163#ent", "<e1>", "phosphorylation", "is", "adipocyte-specific", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008163", "name": "C0008163#ent", "pos": [4, 5]}}
{"token": ["The", "dynamic", "organization", "of", "the", "actin", "cytoskeleton", "the", "force", "for", "cell", "motility", "is", "regulated", "by", "small", "C0018296#ent", "<e1>", "of", "the", "Rho", "family", "in", "particular", "Rac1", ",", "C0084340#ent", "<e2>", "and", "Cdc42", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [16, 17]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [26, 27]}}
{"token": ["In", "the", "present", "study", ",", "we", "explore", "an", "impact", "of", "a", "newly", "identified", "human", "ARHGAP6", "protein", "C0018296#ent", "<e1>", "stimulating", "activity", "for", "C0084340#ent", "<e2>", "on", "the", "catalytic", "properties", "PLC-delta1", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [16, 17]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [21, 22]}}
{"token": ["We", "have", "examined", "the", "human", "humoral", "immune", "response", "against", "C0086376#ent", "<e1>", "of", "Listeria", "monocytogenes", "both", "healthy", "individuals", "and", "C0023860#ent", "<e2>", "patients", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023860", "name": "C0023860#ent", "pos": [18, 19]}}
{"token": ["It", "was", "shown", "that", "immunization", "with", "isolated", "C0086376#ent", "<e1>", "failed", "to", "protect", "mice", "against", "lethal", "C0023860#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023860", "name": "C0023860#ent", "pos": [15, 16]}}
{"token": ["In", "nonketotic", ",", "C0011860#ent", "<e1>", "acute", "exercise", "the", "level", "of", "plasma", "glucose", "whereas", "in", "insulin-deficient", ",", "C0022642#ent", "<e2>", "patients", ",", "blood", "glucose", "increase", "during", "exercise", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022642", "name": "C0022642#ent", "pos": [16, 17]}}
{"token": ["These", "C0003195#ent", "<e1>", ",", "like", "sotalol", ",", "dofetilide", "and", "C0082966#ent", "<e2>", ",", "have", "been", "classified", "as", "Class", "III", "antiarrhythmics"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0082966", "name": "C0082966#ent", "pos": [9, 10]}}
{"token": ["Six", "extra-cellular", "enzyme", "activities", "acid", "and", "alkaline", "phosphatases", "arylsulfatase", ",", "C0041945#ent", "<e1>", ",", "protease", "and", "C0005223#ent", "<e2>", ")", "were", "monitored", "in", "soil", "microcosms", "during", "a", "15-day", "period", "."], "h": {"id": "C0041945", "name": "C0041945#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [15, 16]}}
{"token": ["The", "C0041945#ent", "<e1>", "and", "the", "C0005223#ent", "<e2>", "for", "the", "identification", "of", "the", "mycobacteria", "were", "evaluated", "using", "1,019", "strains", "received", "for", "reference", "purposes", "in", "this", "laboratory", "in", "1978", "."], "h": {"id": "C0041945", "name": "C0041945#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [5, 6]}}
{"token": ["Rats", "were", "tested", "for", "C0003286#ent", "<e1>", "responsivity", "to", "agents", "active", "at", "central", "and", "C1823521#ent", "<e2>", "and", "after", "they", "were", "made", "tolerant", "to", "the", "C0003286#ent", "<e1>", "effects", "of", "carbamazepine", "on", "amygdala-kindled", "seizures", "."], "h": {"id": "C1823521", "name": "C1823521#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [4, 5]}}
{"token": ["The", "importance", "of", "C1420195#ent", "<e1>", "blood", "and", "C0022658#ent", "<e2>", "underscored", "by", "the", "identification", "and", "characterization", "of", "a", "plethora", "of", "novel", "mutations", "in", "the", "AE1", "gene"], "h": {"id": "C1420195", "name": "C1420195#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [7, 8]}}
{"token": ["C0070915#ent", "<e1>", "(", "1", "microM", ")", "inhibited", "the", "degradation", "of", "the", "C0002570#ent", "<e2>", "Tyr1", "-", "3H", "]", "[D-Ala2]-[Leu5]enkephalin", "by", "greater", "than", "95", "%", "."], "h": {"id": "C0070915", "name": "C0070915#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002570", "name": "C0002570#ent", "pos": [11, 12]}}
{"token": ["The", "C1332163#ent", "<e1>", "AP", ")", "complexes", "C0812312#ent", "<e2>", ",", "AP-2", ",", "and", "AP-3", "mediate", "coated", "vesicle", "formation", "and", "sorting", "of", "integral", "membrane", "proteins", "the", "endocytic", "and", "late", "exocytic", "pathways", "mammalian", "cells"], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [6, 7]}}
{"token": ["Here", "we", "show", "that", "C1418833#ent", "<e1>", "Arabidopsis", "is", "located", "in", "the", "soluble", "fraction", "of", "the", "C3179066#ent", "<e2>", "as", "a", "high", "molecular", "weight", "complex"], "h": {"id": "C1418833", "name": "C1418833#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [15, 16]}}
{"token": ["The", "C1257902#ent", "<e1>", "contains", "the", "URA3", "gene", "the", "tetA", "gene", "a", "truncated", "C1421976#ent", "<e2>", ",", "and", "phage", "P1", "recombination", "sites", "at", "either", "end", "."], "h": {"id": "C1257902", "name": "C1257902#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [12, 13]}}
{"token": ["In", "human", "keratinocytes", ",", "we", "have", "recently", "characterized", "a", "low-molecular-weight", "cytosolic", "protein", "15", "C1705240#ent", "<e1>", "that", "specifically", "binds", "fatty", "acids", "C0015923#ent", "<e2>", ")", "with", "high", "affinity", ",", "the", "epidermal", "FA-binding", "protein", "(", "E-FABP", ")", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015923", "name": "C0015923#ent", "pos": [20, 21]}}
{"token": ["oxLDL", "decreased", "C1260386#ent", "<e1>", "levels", "and", "upregulated", "C1366645#ent", "<e2>", "expression", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366645", "name": "C1366645#ent", "pos": [7, 8]}}
{"token": ["We", "analyzed", "HP1-mediated", "inhibition", "of", "preinitiation", "complex", "C0730321#ent", "<e1>", ")", "assembly", "in", "vitro", "chromatin", "templates", "by", "C0118563#ent", "<e2>", "or", "Sp1", "."], "h": {"id": "C0730321", "name": "C0730321#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0118563", "name": "C0118563#ent", "pos": [16, 17]}}
{"token": ["Other", "new", "drugs", "being", "tested", "include", "C1765315#ent", "<e1>", ",", "an", "oral", "serine", "threonine", "kinase", "inhibitor", "vinflunine", ",", "a", "C3536905#ent", "<e2>", "dihydrofolate", "reductase", "inhibitors", "and", "thymidylate", "synthase", "inhibitors"], "h": {"id": "C1765315", "name": "C1765315#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536905", "name": "C3536905#ent", "pos": [18, 19]}}
{"token": ["Hyperpermeability", "is", "a", "crux", "of", "pathogenesis", "of", "sudden", "lung", "edema", "many", "C0034087#ent", "<e1>", "especially", "in", "acute", "lung", "injury", "adult", "C0852283#ent", "<e2>", "ARDS", ")", "."], "h": {"id": "C0034087", "name": "C0034087#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0852283", "name": "C0852283#ent", "pos": [19, 20]}}
{"token": ["Induction", "of", "the", "peroxisomal", "bifunctional", "protein", "C1414322#ent", "<e1>", "by", "clofibrate", "was", "suppressed", "about", "60", "%", "by", "C0028005#ent", "<e2>", "on", "analysis", "of", "the", "hepatic", "protein", "by", "SDS-polyacrylamide", "gel", "electrophoresis"], "h": {"id": "C1414322", "name": "C1414322#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [16, 17]}}
{"token": ["C3536825#ent", "<e1>", "octreotide", ")", "treatment", "initiated", "at", "the", "onset", "of", "C0011849#ent", "<e2>", "prevents", "kidney", "IGF-I", "accumulation", "and", "renal", "growth"], "h": {"id": "C3536825", "name": "C3536825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}}
{"token": ["We", "observed", "an", "inverse", "relationship", "between", "C1840333#ent", "<e1>", "and", "SSA", "when", "RAD51", "or", "C0598034#ent", "<e2>", "was", "impaired", ",", "i.e.", ",", "C1840333#ent", "<e1>", "was", "reduced", "but", "SSA", "was", "increased", "."], "h": {"id": "C1840333", "name": "C1840333#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0598034", "name": "C0598034#ent", "pos": [13, 14]}}
{"token": ["5", ")", "C0023816#ent", "<e1>", "also", "caused", "a", "shift", "of", "C1858114#ent", "<e2>", "to", "HDL2a", "if", "TGRLP", "was", "present", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1858114", "name": "C1858114#ent", "pos": [9, 10]}}
{"token": ["None", "of", "the", "above", "C0036753#ent", "<e1>", "the", "antisecretory", "effect", "of", "C0023992#ent", "<e2>", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023992", "name": "C0023992#ent", "pos": [10, 11]}}
{"token": ["In", "an", "active", "model", "C0017661#ent", "<e1>", "induced", "in", "mice", "by", "repeated", "injections", "of", "C0086140#ent", "<e2>", ",", "some", "of", "the", "mechanisms", "that", "could", "explain", "the", "formation", "of", "glomerular", "IgA", "deposits", "studied", "in", "this", "report", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [13, 14]}}
{"token": ["While", "renal", "insufficiency", "previously", "established", "C0017661#ent", "<e1>", "is", "known", "to", "be", "a", "side", "effect", "C0086140#ent", "<e2>", ",", "cases", "of", "HES-induced", "nephropathy", "have", "so", "far", "not", "been", "reported", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [14, 15]}}
{"token": ["This", "suggests", "that", "type-II", "C1424306#ent", "<e1>", "is", "a", "rather", "ancient", "C0079429#ent", "<e2>", "with", "some", "essential", "function"], "h": {"id": "C1424306", "name": "C1424306#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}}
{"token": ["Phenolic", "compounds", "mints", "are", "found", "to", "poses", "a", "wide", "range", "of", "pharmacological", "activity", "antioxidant", ",", "C0003216#ent", "<e1>", ",", "cytoprotective", ",", "heptoprotective", ",", "C1880071#ent", "<e2>", ",", "chemopreventive", ",", "anti-inflammatory", ",", "antidiabetogenic", "etc", "."], "h": {"id": "C0003216", "name": "C0003216#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1880071", "name": "C1880071#ent", "pos": [22, 23]}}
{"token": ["With", "the", "steady", "increase", "in", "C0023899#ent", "<e1>", "there", "was", "a", "gradual", "decrease", "in", "C0017920#ent", "<e2>", "to", "about", "the", "middle", "of", "April", "and", "a", "slight", "increase", "thereafter", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [13, 14]}}
{"token": ["Hepatocellular", "adenomatosis", "characterized", "by", "the", "presence", "of", "numerous", "(", "arbitrarily", ">", "10", ")", "adenomas", "within", "an", "otherwise", "normal", "C0023899#ent", "<e1>", "without", "a", "history", "of", "C0017920#ent", "<e2>", "steroid", "hormone", "therapy"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [24, 25]}}
{"token": ["A", "2-week", "starvation", "period", "resulted", "in", "a", "statistically", "significant", "increase", "in", "liver", "microsomal", "protein", "and", "a", "decrease", "in", "C0023899#ent", "<e1>", "lipid", "and", "C0017920#ent", "<e2>"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [22, 23]}}
{"token": ["C0297817#ent", "<e1>", "RNRs", ")", "are", "key", "C3541394#ent", "<e2>", "in", "living", "cells", "provide", "the", "precursors", "of", "DNA", "synthesis"], "h": {"id": "C0297817", "name": "C0297817#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [6, 7]}}
{"token": ["Equivalent", "peptides", "derived", "from", "C0297817#ent", "<e1>", "no", "effect", "either", "the", "bacterial", "or", "mammalian", "C3541394#ent", "<e2>", "."], "h": {"id": "C0297817", "name": "C0297817#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["C1427754#ent", "<e1>", "and", "MPO", "C0017337#ent", "<e2>", "encode", "endothelial", "nitric", "oxide", "synthase", "myeloperoxidase", "(", "MPO", ")", ",", "respectively", ",", "which", "generate", "nitric", "oxide", "reactive", "oxygen", "species"], "h": {"id": "C1427754", "name": "C1427754#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}}
{"token": ["Renal", "transplant", "recipients", "C1417840#ent", "<e1>", ")", "and", "patients", "with", "native", "C1561643#ent", "<e2>", "CKD", ")", "have", "similar", "complications", "."], "h": {"id": "C1417840", "name": "C1417840#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [10, 11]}}
{"token": ["Renal", "transplant", "recipients", "C1417840#ent", "<e1>", ")", "and", "patients", "with", "native", "chronic", "kidney", "disease", "C1561643#ent", "<e2>", ")", "have", "similar", "complications", "."], "h": {"id": "C1417840", "name": "C1417840#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [13, 14]}}
{"token": ["A", "73-year-old", "female", "with", "severe", "C0036396#ent", "<e1>", "suffered", "from", "an", "C0751003#ent", "<e2>", "of", "the", "left", "internal", "iliac", "artery"], "h": {"id": "C0036396", "name": "C0036396#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [10, 11]}}
{"token": ["2-Bromooctanoate", "was", "a", "more", "potent", "inhibitor", "of", "C0001022#ent", "<e1>", "expression", "than", "C0133660#ent", "<e2>", "or", "hexanoate", "."], "h": {"id": "C0001022", "name": "C0001022#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0133660", "name": "C0133660#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "Sirius", "red", "staining", "that", "atherosclerotic", "lesions", "mice", "receiving", "C0071097#ent", "<e1>", "had", "higher", "C0009325#ent", "<e2>", "contents", "than", "those", "in", "untreated", "mice", "."], "h": {"id": "C0071097", "name": "C0071097#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}}
{"token": ["As", "with", "NGF", "deprivation", "and", "C0594375#ent", "<e1>", "treatment", ",", "the", "C1511576#ent", "<e2>", "flavopiridol", "and", "olomoucine", "protected", "neurons", "from", "apoptosis", "induced", "by", "AraC", "and", "UV", "treatment", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1511576", "name": "C1511576#ent", "pos": [10, 11]}}
{"token": ["The", "copper", "ion", "five-coordinated", "(", "CuN(4)O", "chromophore", ")", "with", "C1415761#ent", "<e1>", "and", "HBIP", "acting", "as", "C3538717#ent", "<e2>", "and", "bidentate", "ligands", "respectively", "."], "h": {"id": "C1415761", "name": "C1415761#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538717", "name": "C3538717#ent", "pos": [15, 16]}}
{"token": ["C0167183#ent", "<e1>", "distinct", "from", "but", "structurally", "related", "to", "C1419891#ent", "<e2>", "and", "fibroglycan", ",", "two", "previously", "characterized", "members", "of", "this", "family", "of", "membrane-intercalated", "proteoglycans", "."], "h": {"id": "C0167183", "name": "C0167183#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419891", "name": "C1419891#ent", "pos": [8, 9]}}
{"token": ["C0167183#ent", "<e1>", ",", "a", "member", "of", "the", "C1419891#ent", "<e2>", "type", "I", "transmembrane", "heparan", "sulfate", "proteoglycans", "a", "novel", "a", "regulator", "of", "feeding", "behavior", "body", "weight"], "h": {"id": "C0167183", "name": "C0167183#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419891", "name": "C1419891#ent", "pos": [7, 8]}}
{"token": ["PSD-93", "is", "expressed", "in", "discrete", "neuronal", "populations", "well", "as", "in", "specific", "C2364020#ent", "<e1>", "and", "it", "exhibits", "complex", "molecular", "diversity", "attributable", "to", "C1420295#ent", "<e2>", "alternative", "splicing", "."], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [21, 22]}}
{"token": ["It", "was", "also", "demonstrated", "that", "C0030779#ent", "<e1>", "responsiveness", "of", "lymphocytes", "from", "C0020550#ent", "<e2>", "patients", "was", "equal", "to", "that", "of", "lymphocytes", "from", "euthyroid", "controls", "and", "did", "not", "change", "after", "treatment", "with", "131I", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "murine", "C1420706#ent", "<e1>", "is", "highly", "expressed", "in", "C0669372#ent", "<e2>", "in", "the", "normal", "murine", "liver", "and", "is", "upregulated", "in", "non-parenchymal", "cells", "in", "the", "context", "of", "inflammation", "."], "h": {"id": "C1420706", "name": "C1420706#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}}
{"token": ["C2986638#ent", "<e1>", "(", "a", "member", "of", "the", "myogenic", "basic", "C3273649#ent", "<e2>", "seems", "to", "be", "the", "main", "effector", "of", "proliferation", "repression", ",", "a", "crucial", "step", "which", "precedes", "muscle", "cell", "terminal", "differentiation", "during", "muscle", "development"], "h": {"id": "C2986638", "name": "C2986638#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273649", "name": "C3273649#ent", "pos": [9, 10]}}
{"token": ["Twenty", "patients", "with", "known", "malignant", "disease", "C0020437#ent", "<e1>", "were", "randomly", "assigned", "on", "a", "2:1", "basis", "to", "C0037507#ent", "<e2>", "7.5", "mg", "kg-1", "body", "weight", "or", "placebo", "for", "3", "-", "5", "days", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0037507", "name": "C0037507#ent", "pos": [16, 17]}}
{"token": ["n-3", "Polyunsaturated", "fatty", "acids", "mainly", "those", "contained", "in", "C0016157#ent", "<e1>", "are", "candidates", "for", "inclusion", "in", "secondary", "prevention", "programmes", "C0010068#ent", "<e2>", "based", "on", "the", "results", "of", "recent", "randomized", "trials", "humans", "."], "h": {"id": "C0016157", "name": "C0016157#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [18, 19]}}
{"token": ["Oxytocin", ",", "C1366535#ent", "<e1>", "substance", "P", "somatostatin", ",", "neurotensin", ",", "vasoactive", "intestinal", "polypeptide", "C1333714#ent", "<e2>", "not", "detected", "in", "the", "caudal", "neurosecretory", "system", "the", "carp", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [13, 14]}}
{"token": ["Applications", "of", "bradykinin", "(", "Bk", ")", ",", "C1366535#ent", "<e1>", "AVP", ")", ",", "neuromedin", "B", "NmB", ")", ",", "and", "C1333714#ent", "<e2>", "GRP", ")", "to", "Swiss", "3T3", "cells", "induced", "receptor-activated", "currents", "to", "IBn", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [18, 19]}}
{"token": ["Neurotransmitters", "and", "hormones", ",", "such", "as", "C1366535#ent", "<e1>", "AVP", ")", "and", "C1333714#ent", "<e2>", ",", "evoke", "frequency-modulated", "repetitive", "Ca2", "+", "transients", "in", "insulin-secreting", "HIT-T15", "cells", "binding", "to", "receptors", "linked", "to", "phospholipase", "C", "PLC", ")", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [11, 12]}}
{"token": ["These", "were", "enhanced", "by", "the", "addition", "of", "C1366535#ent", "<e1>", "AVP", ")", "and", "C1333714#ent", "<e2>", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [12, 13]}}
{"token": ["Neuropeptides", "particularly", "C1366535#ent", "<e1>", "AVP", ")", "and", "C1333714#ent", "<e2>", "GRP", ")", "act", "as", "autocrine", "and", "paracrine", "growth", "factors", "the", "expression", "of", "these", "and", "their", "receptors", "are", "a", "hallmark", "of", "the", "disease", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [7, 8]}}
{"token": ["PGE1", ",", "forskolin", ",", "and", "C0000096#ent", "<e1>", "also", "decreased", "C0962754#ent", "<e2>", "mRNA", "levels", "in", "human", "skin", "fibroblasts", ",", "demonstrating", "that", "this", "observation", "was", "not", "unique", "to", "the", "HIG-82", "cell", "line", "."], "h": {"id": "C0000096", "name": "C0000096#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [9, 10]}}
{"token": ["Both", "active", "uptake", "efflux", "of", "Ca2", "+", "are", "slowed", "by", "C0005982#ent", "<e1>", "this", "action", "has", "a", "C1416797#ent", "<e2>"], "h": {"id": "C0005982", "name": "C0005982#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416797", "name": "C1416797#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "C0059438#ent", "<e1>", "led", "to", "pronounced", "C1417826#ent", "<e2>", "levels", ",", "whereas", "the", "comet", "assay", "almost", "negative", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417826", "name": "C1417826#ent", "pos": [7, 8]}}
{"token": ["Allspice", "extract", "C0059438#ent", "<e1>", ",", "and", "quercetin", "did", "not", "activate", "C1417826#ent", "<e2>", "but", "enhanced", "CYP3A4", "promoter", "activity"], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417826", "name": "C1417826#ent", "pos": [10, 11]}}
{"token": ["In", "conclusion", ",", "slow", "acetylator", "status", "of", "C1421999#ent", "<e1>", "was", "a", "significant", "susceptibility", "risk", "factor", "C0041296#ent", "<e2>", "drug-induced", "hepatotoxicity", "C1421999#ent", "<e1>", "genotyping", "may", "be", "a", "useful", "tool", "for", "predicting", "C0041296#ent", "<e2>", "drug-induced", "hepatotoxicity", "."], "h": {"id": "C1421999", "name": "C1421999#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [15, 16]}}
{"token": ["Pretreatment", "of", "C0012091#ent", "<e1>", "inhibited", "LPS-induced", "expression", "of", "E-selectin", ",", "intercellular", "adhesion", "molecule-1", "C1706544#ent", "<e2>", ")", "and", "vascular", "cell", "adhesion", "molecule-1", "VCAM-1", ")", "in", "HUVEC", ",", "determined", "by", "flow", "cytometry", "a", "cellular", "enzyme-linked", "immunosorbent", "assay", "cell-ELISA", ")", "."], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [13, 14]}}
{"token": ["We", "report", "a", "case", "of", "C0043325#ent", "<e1>", "and", "lymphoedema", "in", "a", "patient", "who", "has", "C0158617#ent", "<e2>"], "h": {"id": "C0043325", "name": "C0043325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0158617", "name": "C0158617#ent", "pos": [14, 15]}}
{"token": ["Third", ",", "immunopathological", "reactions", ",", "termed", "\"", "the", "C1619738#ent", "<e1>", "\"", "occur", "frequently", "when", "antiretroviral", "therapy", "initiated", "in", "patients", "with", "C0041296#ent", "<e2>", "."], "h": {"id": "C1619738", "name": "C1619738#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [20, 21]}}
{"token": ["We", "made", "a", "retrospective", "longitudinal", "study", "January", "2000", "to", "January", "2003", "to", "examine", "cases", "of", "C1619738#ent", "<e1>", "IRS", ")", "and", "its", "incidence", "rate", "in", "C0041296#ent", "<e2>", "(TB)-human", "immunodeficiency", "virus", "HIV", ")", "co-infected", "patients", "."], "h": {"id": "C1619738", "name": "C1619738#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [24, 25]}}
{"token": ["To", "determine", "the", "frequency", ",", "risk", "factors", "mortality", "rate", "C1619738#ent", "<e1>", "IRIS", ")", "of", "C0041296#ent", "<e2>", "(", "TB", ")", "in", "patients", "co-infected", "with", "HIV/TB", "and", "receiving", "antiretroviral", "therapy", "ART", ")", "."], "h": {"id": "C1619738", "name": "C1619738#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [14, 15]}}
{"token": ["Blockage", "of", "such", "bacterial", "aggregation", "by", "anti-glucosyltransferase", "or", "anti-dextranase", "sera", "suggests", "cross-reactivity", "between", "the", "antigenic", "determinants", "C0086376#ent", "<e1>", "which", "recognize", "alpha(1", "-", "6", ")", "C0017696#ent", "<e2>", "linkages", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017696", "name": "C0017696#ent", "pos": [24, 25]}}
{"token": ["Bacterial", "components", "associated", "with", "adhesion", "phase", "S.", "mutans", "include", "cell-associated", "and", "cell-free", "glucosyltransferases", "GTFs", ")", ",", "as", "well", "as", "protein", "antigen", "c", "C0086376#ent", "<e1>", "that", "bind", "C0017696#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0017696", "name": "C0017696#ent", "pos": [26, 27]}}
{"token": ["In", "vitro", "in", "vivo", "studies", "were", "undertaken", "utilizing", "an", "established", "rat", "glioma", "cell", "line", "C1419009#ent", "<e1>", ")", "to", "compare", "the", "phototoxicity", "characteristics", "of", "C0055390#ent", "<e2>", "AlSPc", ")", ",", "zinc", "tetrasulfonated", "phthalocyanine", "ZnSPc", ")", "and", "haematoporphyrin", "derivative", "HpD", ")", "."], "h": {"id": "C1419009", "name": "C1419009#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0055390", "name": "C0055390#ent", "pos": [23, 24]}}
{"token": ["Generation", "of", "C1415692#ent", "<e1>", "from", "endogenous", "and", "exogenous", "C1415407#ent", "<e2>", "."], "h": {"id": "C1415692", "name": "C1415692#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415407", "name": "C1415407#ent", "pos": [8, 9]}}
{"token": ["Generation", "of", "C1415692#ent", "<e1>", "from", "endogenous", "and", "exogenous", "C1415407#ent", "<e2>", "is", "probably", "due", "to", "a", "proteolytic", "enzyme", "associated", "with", "chromation", "of", "the", "differentiated", "HL-60", "cells"], "h": {"id": "C1415692", "name": "C1415692#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415407", "name": "C1415407#ent", "pos": [8, 9]}}
{"token": ["In", "this", "report", ",", "the", "crystallization", "of", "a", "human", "C1453067#ent", "<e1>", "a", "member", "of", "the", "C1412326#ent", "<e2>", "is", "described", "."], "h": {"id": "C1453067", "name": "C1453067#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412326", "name": "C1412326#ent", "pos": [15, 16]}}
{"token": ["The", "uraemic", "toxins", "that", "accumulate", "in", "C0041948#ent", "<e1>", "plasma", "may", "displace", "the", "C1254351#ent", "<e2>", "from", "its", "specific", "binding", "sites", "plasma", "proteins", "resulting", "in", "increased", "free", "drug", "concentration", "in", "C0041948#ent", "<e1>", "patients", "."], "h": {"id": "C0041948", "name": "C0041948#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["Interpretation", "of", "plasma", "levels", "C0041948#ent", "<e1>", "patients", "must", "take", "into", "account", "decreased", "protein", "binding", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C0041948", "name": "C0041948#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["Desmopressin", "is", "known", "to", "shorten", "prolonged", "bleeding", "time", "in", "C0041948#ent", "<e1>", "but", "mechanism", "of", "the", "haemostatic", "action", "this", "C1254351#ent", "<e2>", "remains", "still", "unknown", "."], "h": {"id": "C0041948", "name": "C0041948#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["The", "establishment", "of", "the", "C0003451#ent", "<e1>", "VSV", "and", "influenza", "virus", "correlated", "with", "the", "induction", "of", "two", "C1333199#ent", "<e2>", "to", "the", "murine", "Mx", "protein", "in", "the", "selective", "resistance", "of", "mice", "to", "influenza", "virus", "infection"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333199", "name": "C1333199#ent", "pos": [16, 17]}}
{"token": ["It", "was", "found", "that", "C1367472#ent", "<e1>", "and", "LM", "were", "organized", "in", "aggregates", ",", "interspersed", "in", "C1333079#ent", "<e2>", "and", "in", "thin", "fibrils", ",", "distributed", "along", "collagen", "fibres"], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333079", "name": "C1333079#ent", "pos": [15, 16]}}
{"token": ["Patients", "with", "oro-facial", "granulomatosis", "have", "C0426576#ent", "<e1>", "be", "investigated", "for", "the", "presence", "of", "C0010346#ent", "<e2>"], "h": {"id": "C0426576", "name": "C0426576#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "the", "C0017337#ent", "<e1>", "encoding", "thymidine", "phosphorylase", "been", "identified", "in", "several", "C1705440#ent", "<e2>", "patients", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705440", "name": "C1705440#ent", "pos": [12, 13]}}
{"token": ["Incorporation", "of", "some", "water-soluble", "polymers", "Ficoll", ",", "C0086140#ent", "<e1>", ")", "into", "the", "assay", "mixture", "shown", "to", "substantially", "increase", "the", "C4284191#ent", "<e2>", "capacity", "of", "both", "soluble", "and", "immobilized", "antibodies", "."], "h": {"id": "C0086140", "name": "C0086140#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284191", "name": "C4284191#ent", "pos": [19, 20]}}
{"token": ["A", "28-yr-old", "woman", "presented", "with", "menstrual", "disturbances", "C0030794#ent", "<e1>", "began", "after", "stopping", "the", "use", "of", "C0009906#ent", "<e2>"], "h": {"id": "C0030794", "name": "C0030794#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009906", "name": "C0009906#ent", "pos": [15, 16]}}
{"token": ["A", "real-time", "multichannel", "fetal", "ECG", "monitor", "based", "on", "a", "personal", "computer", "C3810569#ent", "<e1>", ")", "and", "a", "MOTOROLA", "DSP56001", "Digital", "Signal", "CoProcessor", "(", "C1414174#ent", "<e2>", ")", "is", "introduced", "."], "h": {"id": "C3810569", "name": "C3810569#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414174", "name": "C1414174#ent", "pos": [22, 23]}}
{"token": ["Flight", "cells", "elaborated", "a", "less", "extensive", "extracellular", "matrix", "evidenced", "by", "a", "reduced", "C1333079#ent", "<e1>", "expression", "and", "C0009325#ent", "<e2>", "appearance", "compared", "with", "controls", "."], "h": {"id": "C1333079", "name": "C1333079#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [16, 17]}}
{"token": ["Enhanced", "C1333079#ent", "<e1>", "expression", ",", "increased", "collagen", "synthesis", "decreased", "C0009325#ent", "<e2>", "degradation", ",", "and", "proliferation", "of", "fibroblasts", "have", "all", "been", "proposed", "as", "possible", "contributors", "."], "h": {"id": "C1333079", "name": "C1333079#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [9, 10]}}
{"token": ["We", "studied", "the", "effects", "of", "propranolol", ",", "amantadine", ",", "C0012522#ent", "<e1>", ",", "benztropine", ",", "and", "C0354872#ent", "<e2>", "on", "these", "tremors", "in", "19", "patients", "by", "using", "serial", "accelerometric", "recordings", "."], "h": {"id": "C0012522", "name": "C0012522#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0354872", "name": "C0354872#ent", "pos": [15, 16]}}
{"token": ["Antihistamines", "(", "chlorpheniramine", "and", "C0012522#ent", "<e1>", ")", "and", "antiserotonins", "(", "methysergide", "and", "C0354872#ent", "<e2>", ")", "suppressed", "mouse", "ear", "PCA", "significantly", "."], "h": {"id": "C0012522", "name": "C0012522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0354872", "name": "C0354872#ent", "pos": [12, 13]}}
{"token": ["Her", "fibroblasts", "did", "not", "differ", "from", "normal", "fibroblasts", "in", "sterol", "synthesis", "rate", ",", "cellular", "cholesterol", "C0008385#ent", "<e1>", "content", ",", "or", "incorporation", "of", "C0220884#ent", "<e2>", "into", "C0008385#ent", "<e1>"], "h": {"id": "C0008385", "name": "C0008385#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0220884", "name": "C0220884#ent", "pos": [22, 23]}}
{"token": ["The", "rate", "of", "hydrolysis", "of", "C0008385#ent", "<e1>", "in", "the", "order", ":", "linoleate", "greater", "than", "C0220884#ent", "<e2>", "greater", "than", "valerate", "greater", "than", "butyrate", "greater", "than", "acetate", "."], "h": {"id": "C0008385", "name": "C0008385#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0220884", "name": "C0220884#ent", "pos": [14, 15]}}
{"token": ["Enzyme", "activities", "both", "fractions", "showed", "fatty", "acid", "specificities", "for", "the", "hydrolysis", "of", "different", "C0008385#ent", "<e1>", "the", "following", "decreasing", "order", ":", "Linoleate", "greater", "than", "C0220884#ent", "<e2>", "greater", "than", "palmitate", "."], "h": {"id": "C0008385", "name": "C0008385#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0220884", "name": "C0220884#ent", "pos": [23, 24]}}
{"token": ["Cartilage", "and", "bone", "degradation", "observed", "in", "human", "C0038013#ent", "<e1>", "RA", ")", ",", "are", "caused", "by", "aberrant", "expression", "of", "C0030940#ent", "<e2>", ",", "resulting", "in", "an", "imbalance", "of", "these", "degrading", "enzymes", "and", "their", "inhibitors", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [18, 19]}}
{"token": ["C0008783#ent", "<e1>", "and", "guanidine", "inhibited", "the", "uptake", "of", "C1415651#ent", "<e2>", ",", "whereas", "TEA", "and", "NMN", "did", "not", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415651", "name": "C1415651#ent", "pos": [8, 9]}}
{"token": ["Substrate", "specificity", "demonstrated", "that", "C0016395#ent", "<e1>", "oxidized", "formaldehyde", "in", "the", "presence", "of", "the", "modifin", ";", "a", "diverse", "range", "of", "aldehydes", "and", "C0001975#ent", "<e2>", "were", "oxidized", "by", "C0016395#ent", "<e1>", "in", "the", "absence", "of", "the", "modifin", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0016395", "name": "C0016395#ent", "pos": [4, 5]}}
{"token": ["but", "aspergillus", ",", "waiting", "until", "C0304497#ent", "<e1>", "corticosteroids", ",", "granulocytopenia", ",", "broad-spectrum", "antibiotics", ",", "and", "previous", "C0032285#ent", "<e2>", "destroy", "the", "local", "lung", "defense", ",", "will", "then", "attack", "with", "a", "vengeance", "."], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [16, 17]}}
{"token": ["Therapy", "for", "IPF", "usually", "involves", "corticosteroids", "or", "C0304497#ent", "<e1>", "such", "as", "cyclophosphamide", "or", "azathioprine", ",", "to", "decrease", "C0032285#ent", "<e2>", "retard", "the", "fibrotic", "process", "."], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [17, 18]}}
{"token": ["This", "report", "summarizes", "the", "evidence", "documenting", "a", "role", "for", "oatp1", "and", "C3539701#ent", "<e1>", "in", "GSH", "efflux", "from", "C0669372#ent", "<e2>", ",", "and", "their", "possible", "contribution", "to", "hepatic", "GSH", "homeostasis", "."], "h": {"id": "C3539701", "name": "C3539701#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [17, 18]}}
{"token": ["The", "multidrug", "resistance", "protein", "2", "Mrp2", ")", "also", "called", "canalicular", "multidrug", "resistance", "protein", "cMrp", ")", "or", "canalicular", "multispecific", "organic", "anion", "transporter", "C3539701#ent", "<e1>", ")", "is", "a", "transmembrane", "export", "pump", "at", "the", "canalicular", "domain", "of", "C0669372#ent", "<e2>", "."], "h": {"id": "C3539701", "name": "C3539701#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [34, 35]}}
{"token": ["The", "elevated", "cytokines", "may", "play", "a", "role", "in", "the", "protection", "of", "the", "female", "urinary", "tract", "certain", "renal", "diseases", "such", "as", "C0034186#ent", "<e1>", "and", "other", "inflammatory", "and", "C0022658#ent", "<e2>"], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [20, 21]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [26, 27]}}
{"token": ["C0034186#ent", "<e1>", "different", "diseases", "should", "be", "designated", "by", "the", "term", "\"", "C0022658#ent", "<e2>", "\"", "specifying", "the", "causative", "factor", "and", "the", "character", "of", "affection", "of", "renal", "structures"], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [11, 12]}}
{"token": ["The", "obtained", "results", "suggest", "a", "possible", "disposition", "of", "recipients", "with", "glomerulonephritis", "to", "a", "more", "rapid", "and", "intense", "graft", "rejection", "comparison", "to", "transplant", "patients", "with", "C0034186#ent", "<e1>", "as", "underlying", "C0022658#ent", "<e2>"], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [24, 25]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [28, 29]}}
{"token": ["Glomerulonephritis", ",", "C0034186#ent", "<e1>", ",", "diabetic", "nephropathy", "and", "polycystic", "kidney", "disease", "the", "four", "most", "frequent", "original", "C0022658#ent", "<e2>", "to", "altogether", "500", "kidney", "transplantations", "Rostock", "from", "1976", "to", "1989", "."], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [16, 17]}}
{"token": ["We", "investigate", "the", "value", "of", "combined", "carotid/transcranial", "ultrasound", "testing", "(", "C1424835#ent", "<e1>", ")", "on", "the", "prognosis", "of", "C0007787#ent", "<e2>", "patients", "."], "h": {"id": "C1424835", "name": "C1424835#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [17, 18]}}
{"token": ["A", "double-blind", "study", "choline", "magnesium", "trisalicylate", "Trilisate", "tablets", "Purdue", "Frederick", ")", "(", "CMT", ")", "and", "C0020740#ent", "<e1>", "(", "IPF", ")", "in", "the", "treatment", "of", "C0038013#ent", "<e2>"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [24, 25]}}
{"token": ["indomethacin", "75", "to", "150", "mg", ",", "phenylbutazone", "400", "mg", ",", "naproxen", "500", "mg", ",", "C0020740#ent", "<e1>", "1200", "to", "2400", "mg", "and", "diclofenac", "75", "mg", "in", "C0038013#ent", "<e2>"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [25, 26]}}
{"token": ["A", "randomized", "double-blind", "within-patient", "study", "of", "mefenamic", "acid", "with", "C0020740#ent", "<e1>", "was", "performed", "on", "forty", "patients", "with", "C0038013#ent", "<e2>"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [17, 18]}}
{"token": ["We", "further", "investigated", "sphingolipid", "pathways", "found", "that", "C1412573#ent", "<e1>", "constitutively", "overexpressed", "in", "leukemic", "C1428877#ent", "<e2>", "and", "that", "its", "inhibition", "induced", "apoptosis", "of", "leukemic", "C1428877#ent", "<e2>", "."], "h": {"id": "C1412573", "name": "C1412573#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1428877", "name": "C1428877#ent", "pos": [13, 14]}}
{"token": ["This", "CKM", "fragment", ",", "when", "cloned", "upstream", "of", "the", "rat", "C3714613#ent", "<e1>", "C1332763#ent", "<e2>", ")", "promoter", ",", "mediated", "the", "p53", "transactivation", "C1332763#ent", "<e2>", "."], "h": {"id": "C3714613", "name": "C3714613#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332763", "name": "C1332763#ent", "pos": [12, 13]}}
{"token": ["Expression", "of", "a", "rat", "C3714613#ent", "<e1>", "fusion", "protein", "in", "Escherichia", "coli", "allowed", "isolation", "of", "a", "rat", "C1332763#ent", "<e2>", "cDNA", "clone", "direct", "antibody", "screening", "of", "a", "rat", "brain", "gamma", "gt11", "expression", "library"], "h": {"id": "C3714613", "name": "C3714613#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332763", "name": "C1332763#ent", "pos": [16, 17]}}
{"token": ["With", "the", "exception", "of", "the", "antibodies", "directed", "against", "the", "hydrophobic", "amino-terminal", "segment", "of", "cytochrome", "C0534137#ent", "<e1>", ",", "all", "the", "antipeptide", "antibodies", "the", "major", "C1382176#ent", "<e2>", "C0534137#ent", "<e1>", "and", "-IIB2", "on", "immunoblots", "of", "liver", "microsomal", "proteins"], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1382176", "name": "C1382176#ent", "pos": [23, 24]}}
{"token": ["The", "C0534137#ent", "<e1>", "substrates", "indicate", "a", "decrease", "in", "CYP1A2", ",", "C1382176#ent", "<e2>", ",", "CYP2C9", ",", "and", "CYP3A4", "activities", "in", "HepaRG", "cells", "day", "after", "removal", "of", "DMSO", "from", "the", "medium", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1382176", "name": "C1382176#ent", "pos": [10, 11]}}
{"token": ["Using", "human", "liver", "microsomes", "and", "recombinant", "C0534137#ent", "<e1>", "enzymes", "we", "confirmed", "potent", "inhibition", "of", "C1382176#ent", "<e2>", "enzyme", "activity", "determined", "with", "bupropion", "as", "substrate", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1382176", "name": "C1382176#ent", "pos": [14, 15]}}
{"token": ["The", "C0020364#ent", "<e1>", "activities", "decreased", "even", "more", "than", "the", "two", "C1333828#ent", "<e2>", "activities", ",", "both", "in", "isolated", "cells", "and", "in", "whole", "chick", "embryos", "."], "h": {"id": "C0020364", "name": "C0020364#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [10, 11]}}
{"token": ["C0085228#ent", "<e1>", "elicited", "a", "reliable", "C3813556#ent", "<e2>", "(", "ED50", "=", "24", "mg/kg", ",", "SC", ")", "and", "a", "number", "of", "drugs", "were", "tested", "as", "pre-exposure", "drugs", "."], "h": {"id": "C0085228", "name": "C0085228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [5, 6]}}
{"token": ["Pre-exposure", "to", "C0085228#ent", "<e1>", "prevented", "the", "fluoxetine-induced", "C3813556#ent", "<e2>", ",", "whereas", "pre-exposure", "to", "fluoxetine", "only", "partially", "prevented", "the", "fluvoxamine-induced", "C3813556#ent", "<e2>", "."], "h": {"id": "C0085228", "name": "C0085228#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [7, 8]}}
{"token": ["The", "injury", "to", "the", "alveolar", "epithelium", "capillary", "endothelial", "cells", "extracellular", "matrix", "by", "oxidants", "and/or", "C0030940#ent", "<e1>", "produced", "by", "C3813124#ent", "<e2>", "and", "neutrophils", "results", "in", "the", "derangement", "of", "the", "lung", "parenchyma"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [18, 19]}}
{"token": ["Plasma", "TSH", ",", "basally", "and", "after", "C1421143#ent", "<e1>", "administration", ",", "and", "LH", "and", "C0016424#ent", "<e2>", ",", "before", "and", "after", "gonadotropin-releasing", "hormone", "stimulation", "were", "normal", "up", "to", "1", "yr", "after", "radiation", "."], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [13, 14]}}
{"token": ["C1421143#ent", "<e1>", "and", "LRH", "elicited", "a", "significant", "increase", "in", "TSH", "and", "C0016424#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "a", "bolus", "dose", "C1421143#ent", "<e1>", "elicited", "a", "notable", "increment", "in", "C0016424#ent", "<e2>", ",", "LH", "or", "alpha-SU", "in", "23", "of", "34", "patients", "with", "NFT", "."], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [12, 13]}}
{"token": ["The", "accumulation", "might", "result", "either", "from", "a", "decreased", "volume", "of", "distribution", "secondary", "to", "loss", "of", "body", "weight", "possibly", "drug-induced", ",", "or", "to", "slow", "hepatic", "metabolism", "C0031013#ent", "<e1>", "of", "genetic", "origin", "due", "to", "C0023895#ent", "<e2>", "possibly", "drug-induced", "."], "h": {"id": "C0031013", "name": "C0031013#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [32, 33]}}
{"token": ["C4082693#ent", "<e1>", "has", "proved", "to", "be", "the", "only", "effective", "C0013227#ent", "<e2>", "in", "reducing", "the", "incidence", "of", "recurrences", "."], "h": {"id": "C4082693", "name": "C4082693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}}
{"token": ["In", "summing", "up", ":", "C4082693#ent", "<e1>", "is", "an", "effective", "C0013227#ent", "<e2>", ",", "particularly", "in", "ulcerative", "colitis"], "h": {"id": "C4082693", "name": "C4082693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}}
{"token": ["Early", "C0155668#ent", "<e1>", "education", "is", "urged", "for", "all", "individuals", "with", "a", "positive", "test", "C0003850#ent", "<e2>", "."], "h": {"id": "C0155668", "name": "C0155668#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [13, 14]}}
{"token": ["To", "study", "the", "relationship", "between", "C1414462#ent", "<e1>", "ER", "beta", ")", "polymorphism", "and", "unknown", "C0020624#ent", "<e2>", "Southwestern", "China"], "h": {"id": "C1414462", "name": "C1414462#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020624", "name": "C0020624#ent", "pos": [13, 14]}}
{"token": ["Typically", ",", "several", "C3539946#ent", "<e1>", "identified", "as", "critical", "contact", "residues", "for", "a", "C3540579#ent", "<e2>", "proliferative", "response", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [12, 13]}}
{"token": ["Scavenger", "receptor", "class", "B", "type", "I", "C3540050#ent", "<e1>", ")", "mediates", "the", "selective", "uptake", "of", "HDL", "cholesteryl", "esters", "C0265493#ent", "<e2>", ")", "and", "facilitates", "the", "efflux", "of", "unesterified", "cholesterol"], "h": {"id": "C3540050", "name": "C3540050#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0265493", "name": "C0265493#ent", "pos": [17, 18]}}
{"token": ["Scavenger", "receptor", "class", "B", "type", "I", "C3540050#ent", "<e1>", ")", "mediates", "the", "selective", "uptake", "of", "HDL", "cholesteryl", "esters", "C0265493#ent", "<e2>", ")", "by", "the", "liver", "."], "h": {"id": "C3540050", "name": "C3540050#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0265493", "name": "C0265493#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "C0667828#ent", "<e1>", "facilitates", "tissue", "regeneration", "the", "activation", "of", "the", "collagenase", ",", "C2001899#ent", "<e2>", ",", "that", "degrades", "matrix", "proteins", "bone", "tissue", "microenvironments", "."], "h": {"id": "C0667828", "name": "C0667828#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [15, 16]}}
{"token": ["However", ",", "only", "C1414515#ent", "<e1>", "saturation", ",", "reversibility", ",", "and", "susceptibility", "to", "C3540759#ent", "<e2>"], "h": {"id": "C1414515", "name": "C1414515#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540759", "name": "C3540759#ent", "pos": [12, 13]}}
{"token": ["The", "distribution", "pattern", "was", "also", "not", "different", "for", "PGD", "synthase", "levels", "in", "CSF", "of", "patients", "with", "C0497169#ent", "<e1>", "related", "neuropathies", ",", "C0025297#ent", "<e2>", "fibromyalgia", "."], "h": {"id": "C0497169", "name": "C0497169#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [21, 22]}}
{"token": ["The", "present", "case", "shows", "the", "importance", "of", "the", "inclusion", "of", "this", "bacterium", "in", "the", "differential", "diagnosis", "the", "neurological", "infections", "C0497169#ent", "<e1>", "patients", "and", "emphasizes", "the", "importance", "of", "considering", "the", "C0025297#ent", "<e2>", "this", "population", "."], "h": {"id": "C0497169", "name": "C0497169#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [29, 30]}}
{"token": ["We", "report", "here", "that", "reduced", "pyridine", "nucleotides", "reduced", "glutathione", "result", "in", "an", "oxidation", "of", "Amplex", "Red", "by", "C0599874#ent", "<e1>", "that", "is", "dependent", "on", "the", "presence", "of", "horseradish", "peroxidase", "C3889156#ent", "<e2>", ")", "."], "h": {"id": "C0599874", "name": "C0599874#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3889156", "name": "C3889156#ent", "pos": [28, 29]}}
{"token": ["ACTH", "normalized", "the", "activities", "investigated", "in", "patients", "with", "exacerbating", "course", "C0026769#ent", "<e1>", "but", "had", "no", "influence", "on", "C0020289#ent", "<e2>", "in", "the", "progressive", "form", "of", "the", "disease", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "we", "evaluate", "the", "packing", "efficacy", "of", "C0206141#ent", "<e1>", "using", "a", "silicone", "model", "C0162869#ent", "<e2>"], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162869", "name": "C0162869#ent", "pos": [16, 17]}}
{"token": ["The", "divergence", "point", "seemed", "to", "be", "downstream", "of", "HGF/c-Src", "and", "consisted", "in", "the", "interaction", "between", "C1307053#ent", "<e1>", "and", "the", "C1366355#ent", "<e2>", "HDAC3", ")", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1366355", "name": "C1366355#ent", "pos": [19, 20]}}
{"token": ["The", "divergence", "point", "seemed", "to", "be", "downstream", "of", "HGF/c-Src", "and", "consisted", "in", "the", "interaction", "between", "C1307053#ent", "<e1>", "and", "the", "substrate", "histone", "deacetylase", "3", "C1366355#ent", "<e2>", ")", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1366355", "name": "C1366355#ent", "pos": [23, 24]}}
{"token": ["The", "C1305923#ent", "<e1>", "was", "modified", "when", "using", "the", "isolated", "C1412125#ent", "<e2>", "sodium", "bromide-treated", "submitochondrial", "particles", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [9, 10]}}
{"token": ["Photosystem", "II", "membranes", "were", "depleted", "of", "Ca2", "+", "and", "the", "17-", "and", "23-kDa", "C1305923#ent", "<e1>", "by", "treatment", "with", "C1412125#ent", "<e2>", "and", "EGTA", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "the", "association", "between", "C1704939#ent", "<e1>", "3435C", "to", "T", "polymorphism", "colchicine", "response", "patients", "with", "C0031069#ent", "<e2>", "."], "h": {"id": "C1704939", "name": "C1704939#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [15, 16]}}
{"token": ["C1423716#ent", "<e1>", "is", "present", "as", "a", "soluble", "factor", "while", "C1416853#ent", "<e2>", "is", "partly", "attached", "to", "the", "plastid", "membranes"], "h": {"id": "C1423716", "name": "C1423716#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416853", "name": "C1416853#ent", "pos": [9, 10]}}
{"token": ["This", "region", "comprises", "two", "sets", "of", "overlapping", "coding", "sequences", "the", "first", "set", "codes", "for", "the", "newly", "identified", "C1823643#ent", "<e1>", "and", "H2", "polypeptides", "the", "second", "set", "codes", "for", "polypeptides", "G1", "C1824309#ent", "<e2>", "."], "h": {"id": "C1823643", "name": "C1823643#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1824309", "name": "C1824309#ent", "pos": [29, 30]}}
{"token": ["The", "time", "constant", "the", "rapid", "recovery", "phase", "(", "C1446659#ent", "<e1>", "was", "abbreviated", "by", "C0035983#ent", "<e2>", ",", "ouabain", "and", "adrenaline", "in", "human", "myocardium", "and", "by", "C0035983#ent", "<e2>", "alone", "in", "guinea-pig", "."], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035983", "name": "C0035983#ent", "pos": [13, 14]}}
{"token": ["This", "approach", "determined", "that", "C4084875#ent", "<e1>", ",", "an", "uncharacterized", "C0014442#ent", "<e2>", "highly", "elevated", "in", "aggressive", "cancer", "cells", "serves", "as", "a", "central", "node", "an", "ether", "lipid", "signaling", "network", "that", "bridges", "platelet-activating", "factor", "lysophosphatidic", "acid"], "h": {"id": "C4084875", "name": "C4084875#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["In", "Saccharomyces", "cerevisiae", "the", "two", "PASKIN", "orthologues", "PSK1", "and", "C4084875#ent", "<e1>", "phosphorylate", "three", "translation", "factors", "two", "C0014442#ent", "<e2>", "involved", "in", "glycogen", "synthesis", "thereby", "coordinately", "regulating", "protein", "synthesis", "glycolytic", "flux", "."], "h": {"id": "C4084875", "name": "C4084875#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["The", "inversion", "results", "from", "homologous", "recombination", "the", "A", "gene", "located", "in", "intron", "22", "the", "C2732002#ent", "<e1>", "one", "of", "the", "two", "C0079429#ent", "<e2>", "thus", "disrupting", "the", "coding", "sequence", "the", "factor", "VIII", "gene"], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [20, 21]}}
{"token": ["Five", "who", "did", "not", "receive", "amphoteicin", "B", "AMPH", ")", "died", "of", "C0085605#ent", "<e1>", "whereas", "the", "other", "six", "who", "received", "AMPH", "and/or", "C0025942#ent", "<e2>", "or", "fluconazole", "were", "cured", "."], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [21, 22]}}
{"token": ["EPO", "activates", "the", "tyrosine", "phosphorylation", "C2986916#ent", "<e1>", ",", "resulting", "in", "the", "interdependent", "recruitment", "of", "Shc", "and", "C1333707#ent", "<e2>", "."], "h": {"id": "C2986916", "name": "C2986916#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333707", "name": "C1333707#ent", "pos": [16, 17]}}
{"token": ["Numerous", "microbial", "as", "well", "as", "other", "stimulants", "including", "lipopolysaccharide", "and", "C0678133#ent", "<e1>", "can", "activate", "TLR4", ",", "and", "elicit", "diverse", "downstream", "signaling", "including", "C1333196#ent", "<e2>", "and", "cell", "growth", "regulation"], "h": {"id": "C0678133", "name": "C0678133#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [22, 23]}}
{"token": ["There", "exists", "a", "growing", "body", "of", "research", "which", "indicates", "that", "antimitotics", "such", "as", "C0678133#ent", "<e1>", "and", "colchicine", "influence", "C1333196#ent", "<e2>", "."], "h": {"id": "C0678133", "name": "C0678133#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [18, 19]}}
{"token": ["We", "have", "obtained", "novel", "adenovirus-SV40", "recombinant", "viruses", "express", "C2987364#ent", "<e1>", "SV40", "large", "T", "and", "small", "t", "antigens", "the", "control", "of", "different", "C0001486#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [21, 22]}}
{"token": ["Growth", "factors", "C2349086#ent", "<e1>", "are", "produced", "during", "ischaemia", "and", "stimulate", "C1418724#ent", "<e2>", "release", "and", "activation", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418724", "name": "C1418724#ent", "pos": [10, 11]}}
{"token": ["The", "p53", "expression", "was", "not", "correlated", "with", "the", "expressions", "of", "C2349086#ent", "<e1>", ",", "bFGF", ",", "and", "TSP-1", "in", "C1418724#ent", "<e2>", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418724", "name": "C1418724#ent", "pos": [18, 19]}}
{"token": ["Nizer", "demonstrated", "rapid", "and", "powerful", "C0728960#ent", "<e1>", "and", "antipyretic", "effects", "compared", "to", "plain", "C0132515#ent", "<e2>", ",", "without", "additional", "side", "effects"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0132515", "name": "C0132515#ent", "pos": [13, 14]}}
{"token": ["The", "anti-inflammatory", "and", "C0728960#ent", "<e1>", "orally", "administered", "C0132515#ent", "<e2>", "and", "ketoprofen", "were", "assessed", "in", "a", "group", "of", "71", "paediatric", "patients", "(", "aged", "7", "to", "14", "years", ")", "with", "orthopaedic", "disorders"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0132515", "name": "C0132515#ent", "pos": [7, 8]}}
{"token": ["Nineteen", "C0751003#ent", "<e1>", "were", "visualized", "in", "cerebral", "angiography", "21", "cases", "with", "SAH", "or", "C0028866#ent", "<e2>", "whereas", "in", "IVDSA", "15", "C0751003#ent", "<e1>", "were", "noted", "."], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0028866", "name": "C0028866#ent", "pos": [13, 14]}}
{"token": ["In", "this", "article", ",", "we", "review", "our", "experience", "with", "small", "unruptured", "C0751003#ent", "<e1>", "presenting", "with", "C0028866#ent", "<e2>"], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0028866", "name": "C0028866#ent", "pos": [15, 16]}}
{"token": ["Minutes", "after", "DNA", "damage", "the", "variant", "histone", "H2AX", "is", "phosphorylated", "by", "C0033640#ent", "<e1>", "the", "phosphoinositide", "kinase", "family", "including", "C0004135#ent", "<e2>", ",", "ATR", "or", "DNA-PK", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [18, 19]}}
{"token": ["The", "mutated", "gene", "results", "in", "NBS", "codes", "for", "nibrin", "(", "Nbs1/p95", ")", ",", "a", "DNA", "repair", "protein", "is", "functionally", "linked", "to", "ATM", ",", "the", "C0033640#ent", "<e1>", "the", "gene", "responsible", "of", "C0004135#ent", "<e2>", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [30, 31]}}
{"token": ["Eukaryotic", "genome", "integrity", "safeguarded", "by", "two", "highly", "conserved", "C0033640#ent", "<e1>", "are", "called", "ATR", "and", "C0004135#ent", "<e2>", "for", "humans", "and", "Mec1", "and", "Tel1", "for", "Saccharomyces", "cerevisiae"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [14, 15]}}
{"token": ["C0162429#ent", "<e1>", "leads", "to", "depletion", "of", "liver", "C0003402#ent", "<e2>", "accelerated", "release", "of", "hepatic", "oxygen", "free", "radicals"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [7, 8]}}
{"token": ["C0162429#ent", "<e1>", "with", "deficiency", "of", "proteins", "and", "micronutrients", "with", "C0003402#ent", "<e2>", "food-based", "toxins", ",", "such", "as", "cassava", ",", "which", "contain", "cyanogenic", "glycosides", "been", "suspected", "as", "possible", "aetiological", "factors"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [9, 10]}}
{"token": ["Receptor", "binding", "experiments", "that", "except", "for", "the", "C0005059#ent", "<e1>", "nipecotic", "acid", "the", "GABA", "C2987634#ent", "<e2>", "have", "little", "affinity", "for", "the", "cholinergic", "muscarinic", "receptor", "site"], "h": {"id": "C0005059", "name": "C0005059#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}}
{"token": ["NIH-9834", "(", "N-[6", ",", "14-endoetheno-7", ",", "8-dihydromorphine-7-alpha-carbonyl]-L-phenylalanyl-L-leucinol", ")", "and", "its", "C0005059#ent", "<e1>", "NIH-9833", ",", "were", "potent", "C2987634#ent", "<e2>", "upon", "the", "vas", "deferens"], "h": {"id": "C0005059", "name": "C0005059#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [16, 17]}}
{"token": ["Regarding", "TG", "synthesis", ",", "DGAT-1", "decreased", "while", "C1418780#ent", "<e1>", "increased", "and", "FAS", ",", "C1416902#ent", "<e2>", "and", "DGAT-2", "remained", "unchanged", "."], "h": {"id": "C1418780", "name": "C1418780#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [13, 14]}}
{"token": ["In", "China", ",", "C0017605#ent", "<e1>", "a", "blinding", "eye", "disease", "high", "incidence", "in", "C0017601#ent", "<e2>", "with", "different", "clinical", "course", "features", "from", "acute", "angle-closure", "glaucoma"], "h": {"id": "C0017605", "name": "C0017605#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [12, 13]}}
{"token": ["The", "epidermal", "Langerhans'", "cells", "C1423693#ent", "<e1>", ")", "were", "observed", "sequentially", "by", "both", "C1706373#ent", "<e2>", "ATPase", ")", "and", "electron", "microscopy"], "h": {"id": "C1423693", "name": "C1423693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [12, 13]}}
{"token": ["The", "C1423693#ent", "<e1>", "stained", "positive", "with", "C1706373#ent", "<e2>", "and", "with", "antibodies", "to", "HLA-DR", "antigen", "were", "negative", "to", "DOPA-oxidase", "."], "h": {"id": "C1423693", "name": "C1423693#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [6, 7]}}
{"token": ["The", "saturated", "fatty", "acids", "released", "from", "the", "C1420193#ent", "<e1>", "four", "patients", "with", "C1412084#ent", "<e2>", "(", "ALD", ")", "and", "14", "diseased", "controls", "were", "analyzed", "by", "high", "performance", "liquid", "chromatography"], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412084", "name": "C1412084#ent", "pos": [12, 13]}}
{"token": ["However", ",", "two", "other", "mood", "stabilizing", "C0006949#ent", "<e1>", "lamotrigine", "had", "no", "effect", "expression", "of", "C1415761#ent", "<e2>", ",", "GRP94", "or", "calreticulin", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415761", "name": "C1415761#ent", "pos": [14, 15]}}
{"token": ["This", "review", "highlights", "the", "importance", "of", "C1417679#ent", "<e1>", "such", "as", "C1413815#ent", "<e2>", "understanding", "bone", "remodelling", "illustrates", "a", "new", "trend", "towards", "understanding", "bone", "disease", "a", "complete", "entity", "rather", "than", "as", "a", "series", "of", "unrelated", "disorders"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413815", "name": "C1413815#ent", "pos": [10, 11]}}
{"token": ["Future", "identification", "of", "C1332838#ent", "<e1>", "implications", "for", "understanding", "the", "human", "variability", "to", "C0023886#ent", "<e2>"], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023886", "name": "C0023886#ent", "pos": [12, 13]}}
{"token": ["NSAIDs", "are", "bound", "stereoselectively", "to", "serum", "albumin", "different", "degrees", "depending", "on", "the", "drug", "investigated", "ibuprofen", ",", "C0015837#ent", "<e1>", ",", "carprofen", ",", "etodolac", ",", "ketoprofen", "and", "C0016377#ent", "<e2>", ")", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0016377", "name": "C0016377#ent", "pos": [25, 26]}}
{"token": ["The", "tear", "arose", "during", "the", "treatment", "of", "C0518958#ent", "<e1>", "total", "knee", "arthroplasty", "the", "patient", "attempted", "full", "weight-bearing", "with", "the", "affected", "C0030196#ent", "<e2>", "in", "a", "semiflexion", "position", "and", "twisted", "the", "knee", "."], "h": {"id": "C0518958", "name": "C0518958#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [20, 21]}}
{"token": ["The", "direct", "binding", "between", "PKN", "and", "each", "subunit", "of", "C1826396#ent", "<e1>", "was", "confirmed", "by", "using", "the", "in", "vitro", "amino-terminal", "region", "PKN", "and", "C0017837#ent", "<e2>", "the", "head-rod", "domain", "of", "each", "subunit", "of", "C1826396#ent", "<e1>", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [22, 23]}}
{"token": ["The", "auto-antibody", "recognized", "C1870461#ent", "<e1>", "immunoblots", "and", "immunoprecipitated", "the", "C0031727#ent", "<e2>", "with", "intact", "enzyme", "activity"], "h": {"id": "C1870461", "name": "C1870461#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}}
{"token": ["C0596007#ent", "<e1>", "is", "widely", "used", "in", "C0035435#ent", "<e2>", "hepatic", "side", "effects", "not", "been", "reported", "previously", "."], "h": {"id": "C0596007", "name": "C0596007#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [6, 7]}}
{"token": ["It", "has", "been", "proposed", "that", "increased", "levels", "of", "these", "C1423842#ent", "<e1>", "cytokines", "activate", "coagulation", "via", "up-regulating", "the", "novel", "prothrombinase", ",", "C1414609#ent", "<e2>", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414609", "name": "C1414609#ent", "pos": [20, 21]}}
{"token": ["This", "study", "further", "investigates", "the", "C1423842#ent", "<e1>", "cytokine", "up-regulation", "of", "C1414609#ent", "<e2>", "expression", "in", "a", "pathophysiological", ",", "stress", "induced", "abortion", "model", "and", "an", "inflammatory", ",", "interleukin-12", "(", "IL-12", ")", "triggered", "abortion", "model"], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414609", "name": "C1414609#ent", "pos": [10, 11]}}
{"token": ["UMG1", "-", "2", ",", "which", "C0669365#ent", "<e1>", "expresses", "HCMV", "immediate-early", "protein-1", "C1705742#ent", "<e2>", ")", ",", "had", "resistance", "to", "apoptosis", "induced", "by", "etoposide", "as", "compared", "with", "the", "parental", "cell", "line", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705742", "name": "C1705742#ent", "pos": [11, 12]}}
{"token": ["In", "addition", "to", "ICS1", ",", "PR", "and", "other", "defence-related", "genes", "are", "C0669365#ent", "<e1>", "expressed", "in", "C1705742#ent", "<e2>", "plants", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705742", "name": "C1705742#ent", "pos": [15, 16]}}
{"token": ["However", ",", "C1366535#ent", "<e1>", "failed", "to", "affect", "AP", "configuration", "or", "C1333690#ent", "<e2>", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [10, 11]}}
{"token": ["These", "results", "indicate", "that", "H(+)-ATPase", "participates", "the", "cellular", "action", "C1366535#ent", "<e1>", "mediated", "via", "the", "C1333690#ent", "<e2>", "control", "in", "renal", "papillary", "collecting", "tubule", "cells", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [14, 15]}}
{"token": ["Our", "review", "elaborates", "on", "possible", "explanations", "for", "C0016957#ent", "<e1>", "suppression", "and", "on", "other", "explanations", "for", "increased", "C0017978#ent", "<e2>", "concentration", "within", "cancer", "cell", "membranes"], "h": {"id": "C0016957", "name": "C0016957#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017978", "name": "C0017978#ent", "pos": [16, 17]}}
{"token": ["The", "efficacy", "of", "C0039902#ent", "<e1>", "in", "the", "treatment", "of", "severe", "cases", "of", "C0033860#ent", "<e2>", "is", "demonstrated", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [12, 13]}}
{"token": ["In", "the", "search", "for", "C1332838#ent", "<e1>", "for", "malignant", "growth", "S115", "mouse", "mammary", "tumor", "cells", "found", "that", "thrombospondin", "1", "C1420884#ent", "<e2>", ")", "expression", "was", "strongly", "downregulated", "by", "testosterone", "(", "Te", ")", "."], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420884", "name": "C1420884#ent", "pos": [18, 19]}}
{"token": ["The", "cytotoxicity", "of", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "to", "human", "arterial", "smooth", "muscle", "cells", "C1539322#ent", "<e1>", ")", "infected", "with", "cytomegalovirus", "(", "CMV", ")", "or", "herpes", "simplex", "virus-1", "C0019348#ent", "<e2>", ")", "was", "investigated", "."], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [28, 29]}}
{"token": ["In", "addition", ",", "when", "only", "a", "portion", "of", "the", "C1539322#ent", "<e1>", "population", "received", "the", "C0019348#ent", "<e2>", "tk", "transgene", ",", "an", "inhibitory", "effect", "on", "neighboring", "SMCs", "was", "evident", "."], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [14, 15]}}
{"token": ["We", "report", "here", "that", "OS-9", "and", "XTP3-B/Erlectin", "are", "ER-resident", "C0072522#ent", "<e1>", "that", "bind", "to", "ERAD", "substrates", "and", ",", "through", "the", "C1419939#ent", "<e2>", "to", "the", "ER-membrane-embedded", "ubiquitin", "ligase", "Hrd1", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419939", "name": "C1419939#ent", "pos": [20, 21]}}
{"token": ["C0006982#ent", "<e1>", "administered", "before", "the", "second", "C0011777#ent", "<e2>", "dose", "blunted", "both", "the", "diuretic", "and", "the", "natriuretic", "response", "haloperidol", "abolished", "or", "blunted", "all", "the", "effects", "of", "the", "second", "C0011777#ent", "<e2>", "dose", "."], "h": {"id": "C0006982", "name": "C0006982#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [6, 7]}}
{"token": ["The", "cytoplasm", "of", "ghost", "cells", "in", "calcifying", "C0028879#ent", "<e1>", "distinct", "immunolocalization", "of", "the", "C4288353#ent", "<e2>", "while", "similar", "in", "the", "calcifying", "epitheliomas", "the", "skin", "showed", "a", "negative", "reaction"], "h": {"id": "C0028879", "name": "C0028879#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4288353", "name": "C4288353#ent", "pos": [13, 14]}}
{"token": ["Transient", "knockdown", "of", "ezrin", "protein", "MAPK", "and", "PI3K", "signaling", "well", "as", "C0919336#ent", "<e1>", "expression", "and", "invasiveness", "in", "cancer", "cells", "overexpressing", "C0137431#ent", "<e2>", "."], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0137431", "name": "C0137431#ent", "pos": [20, 21]}}
{"token": ["Here", ",", "we", "studied", "the", "effect", "of", "such", "prolonged", "exposure", "to", "C0060926#ent", "<e1>", "on", "a", "rat", "sodium", "channel", "C1419858#ent", "<e2>", "."], "h": {"id": "C0060926", "name": "C0060926#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419858", "name": "C1419858#ent", "pos": [18, 19]}}
{"token": ["Chromatin", "immunoprecipitation", "show", "that", "C1335290#ent", "<e1>", "and", "its", "cyclin", "partner", "C1332782#ent", "<e2>", "are", "recruited", "to", "transcription", "elongation", "complexes", ",", "cross-linking", "to", "actively", "transcribing", "genes", "."], "h": {"id": "C1335290", "name": "C1335290#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332782", "name": "C1332782#ent", "pos": [10, 11]}}
{"token": ["Subunit", "mRNA", "combinations", "that", "can", "result", "in", "functional", "KATP", "channels", "Kir6.1", "together", "with", "C1335290#ent", "<e1>", ",", "Kir6.2", "together", "with", "C1335290#ent", "<e1>", "or", "C1332782#ent", "<e1>", ")", "were", "detected", "in", "only", "17", "%", "of", "the", "pyramidal", "cells"], "h": {"id": "C1335290", "name": "C1335290#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332782", "name": "C1332782#ent", "pos": [22, 23]}}
{"token": ["The", "Golgi", "fraction", "not", "contain", "appreciable", "amounts", "of", "enzymes", "such", "as", "ATPase", ",", "C2932861#ent", "<e1>", ",", "glycosidase", ",", "glucose-6-phosphatase", ",", "acid", "phosphatase", "or", "C0038613#ent", "<e2>"], "h": {"id": "C2932861", "name": "C2932861#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038613", "name": "C0038613#ent", "pos": [23, 24]}}
{"token": ["This", "C0027203#ent", "<e1>", "is", "now", "shown", "to", "be", "inhibited", "by", "C0668441#ent", "<e2>", "PACOCF3", ")", ",", "arachidonyl", "trifluoromethyl", "ketone", "AACOCF3", ")", ",", "and", "a", "bromoenol", "lactone", "BEL", ")", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0668441", "name": "C0668441#ent", "pos": [10, 11]}}
{"token": ["We", "developed", "a", "reproducible", "animal", "model", "the", "induction", "of", "C0041974#ent", "<e1>", "the", "rabbit", "and", "evaluated", "the", "role", "of", "C0062095#ent", "<e2>", "in", "limiting", "stricture", "formation", "."], "h": {"id": "C0041974", "name": "C0041974#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0062095", "name": "C0062095#ent", "pos": [18, 19]}}
{"token": ["These", "C0012634#ent", "<e1>", "are", "associated", "with", "production", "of", "reactive", "oxygen", "species", "C0812281#ent", "<e2>", ")", "from", "infiltrated", "macrophages", "and", "neutrophiles", "in", "inflammatory", "sites"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [11, 12]}}
{"token": ["C1874769#ent", "<e1>", "work", "by", "hydrating", "the", "C0010803#ent", "<e2>", "these", "sheets", "of", "desquamated", "stratum", "corneum", "and", "subsequently", "inducing", "keratolysis", ",", "with", "disintegration", "of", "the", "wax", "."], "h": {"id": "C1874769", "name": "C1874769#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [6, 7]}}
{"token": ["As", "has", "been", "reported", "for", "WAS", "and", "some", "cases", "of", "C1839163#ent", "<e1>", ",", "almost", "total", "inactivation", "of", "the", "XLTT", "C0678928#ent", "<e2>", "observed", "in", "granulocytes", "and", "peripheral", "blood", "mononuclear", "cells", "1", "asymptomatic", "obligate", "carrier", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [19, 20]}}
{"token": ["The", "Wiskott-Aldrich", "syndrome", "WAS", ")", "is", "a", "disease", "of", "profound", "C1839163#ent", "<e1>", "and", "severe", "immune", "defects", "by", "an", "unidentified", "defective", "C0678928#ent", "<e2>"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [20, 21]}}
{"token": ["Wiskott-Aldrich", "syndrome", "WAS", ")", "and", "X-linked", "thrombocytopenia", "C1839163#ent", "<e1>", ")", "are", "rare", "C0678928#ent", "<e2>", "by", "mutations", "of", "the", "Wiskott-Aldrich", "syndrome", "protein", "WASP", ")", "gene", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [12, 13]}}
{"token": ["However", ",", "neither", "C0022642#ent", "<e1>", "nor", "terbutaline", "significantly", "changed", "the", "C1839259#ent", "<e2>", "values", "in", "either", "group", "."], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [10, 11]}}
{"token": ["c", ")", "The", "position", "of", "TSM1", "is", "between", "C1417826#ent", "<e1>", "and", "the", "two", "closely", "linked", "loci", "C1419407#ent", "<e2>", "and", "RIB3", ",", "OLI1", "is", "outside", "and", "not", "linked", "to", "the", "segment", "PAR-TSM-RIB", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419407", "name": "C1419407#ent", "pos": [16, 17]}}
{"token": ["b", ")", "Locus", "TSM1", "appears", "to", "be", "weakly", "linked", "to", "the", "C1417826#ent", "<e1>", "to", "the", "loci", "C1419407#ent", "<e2>", "and", "RIB3", "but", "unlinked", "to", "the", "locus", "OLI1", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419407", "name": "C1419407#ent", "pos": [16, 17]}}
{"token": ["C0002085#ent", "<e1>", "variations", "in", "the", "C1327841#ent", "<e2>", "and", "HEXB", "genes", "cause", "the", "fatal", "inborn", "errors", "metabolism", "Tay-Sachs", "disease", "Sandhoff", "disease", "respectively", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1327841", "name": "C1327841#ent", "pos": [5, 6]}}
{"token": ["C0001645#ent", "<e1>", "unable", "to", "prevent", "the", "contractions", "triggered", "by", "the", "C3541403#ent", "<e2>"], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541403", "name": "C3541403#ent", "pos": [10, 11]}}
{"token": ["The", "lines", "have", "C4042483#ent", "<e1>", "rearrangement", "and", "they", "are", "positive", "for", "CD19", ",", "C1417326#ent", "<e2>", ",", "CD22", ",", "CD39", "."], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417326", "name": "C1417326#ent", "pos": [13, 14]}}
{"token": ["The", "ratios", "of", "tissue", "per", "plasma", "for", "total", "C1412244#ent", "<e1>", "and", "for", "C1412244#ent", "<e1>", "values", "in", "the", "C0023899#ent", "<e1>", ",", "kidney", "and", "heart", "showed", "a", "two-digit", "magnitude", "each", "time", "they", "were", "examined", "."], "h": {"id": "C1412244", "name": "C1412244#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [17, 18]}}
{"token": ["As", "for", "the", "drug", "concentration", "the", "adjacent", "organs", "C1412244#ent", "<e1>", "was", "detected", "in", "slight", "high", "level", "in", "the", "C0023899#ent", "<e2>", ",", "less", "in", "the", "spleen", "and", "pancreas", "."], "h": {"id": "C1412244", "name": "C1412244#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}}
{"token": ["The", "apparent", "subcellular", "distribution", "of", "adriamycin", "(", "C1412244#ent", "<e1>", ")", "was", "investigated", "in", "the", "C0023899#ent", "<e2>", "and", "primary", "or", "metastatic", "tumor", "tissue", "C57BL/6", "mice", "i.m", "."], "h": {"id": "C1412244", "name": "C1412244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [14, 15]}}
{"token": ["A", "combination", "of", "hypoparathyroidism", ",", "sensorineural", "deafness", "and", "renal", "dysplasia", "been", "considered", "to", "be", "a", "new", "C0039082#ent", "<e1>", "inherited", "in", "an", "autosomal", "dominant", "fashion", "we", "name", "the", "condition", "\"", "C1840333#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C1840333", "name": "C1840333#ent", "pos": [29, 30]}}
{"token": ["Prominent", "changes", "were", "observed", "in", "Kupffer", "cells", "KCs", ")", "and", "melanomacrophages", "(", "C0623362#ent", "<e1>", ")", ",", "both", "showing", "intense", "reactivity", "for", "AcPase", "and", "C0007367#ent", "<e2>", "and", "variations", "in", "melanin", "content", "and", "distribution", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [23, 24]}}
{"token": ["Two", "hundred", "and", "ninety-six", "patients", "were", "enrolled", "in", "a", "6-month", ",", "open-label", "tolerability", "study", "enteric-coated", "C0027396#ent", "<e1>", "in", "patients", "with", "rheumatoid", "arthritis", "n", "=", "174", ")", "and", "C0029408#ent", "<e2>", "(", "n", "=", "122", ")", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [27, 28]}}
{"token": ["Here", "we", "demonstrate", "a", "novel", "method", "of", "repetitively", "tracking", "in", "vivo", "gene", "expression", "C0311727#ent", "<e1>", "FL", ")", "in", "skeletal", "muscles", "mice", "using", "a", "cooled", "charged", "coupled", "device", "C0008928#ent", "<e2>", ")", "camera", "."], "h": {"id": "C0311727", "name": "C0311727#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0008928", "name": "C0008928#ent", "pos": [27, 28]}}
{"token": ["The", "influence", "of", "TNF-alpha", "-308", "polymorphism", "was", "examined", "in", "patients", "with", "systemic", "lupus", "erythematosus", "SLE", ")", ",", "rheumatoid", "arthritis", "RA", ")", ",", "C0151449#ent", "<e1>", "pSS", ")", "and", "C0041296#ent", "<e2>", "."], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [27, 28]}}
{"token": ["C1418938#ent", "<e1>", "(", "1", "mg/day", ")", "administered", "simultaneously", "with", "C2675227#ent", "<e2>", "increased", "progesterone", "to", "levels", "even", "higher", "than", "those", "in", "control", "rats", "and", "restored", "20-alpha-hydroxypregn-4-en-3-oen", "levels", "to", "those", "of", "the", "controls", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2675227", "name": "C2675227#ent", "pos": [9, 10]}}
{"token": ["A", "C1257902#ent", "<e1>", "mutant", "of", "P.", "putida", "that", "was", "defective", "in", "the", "C3536834#ent", "<e2>", "ssuD", ")", "was", "unable", "to", "grow", "with", "either", "methanesulfonate", "or", "methionine", "as", "the", "sulfur", "source"], "h": {"id": "C1257902", "name": "C1257902#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536834", "name": "C3536834#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "deterioration", "of", "lung", "C1367657#ent", "<e1>", "not", "invariably", "associated", "with", "C0032285#ent", "<e2>"], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}}
{"token": ["Major", "complications", ",", "including", "dislocation", "of", "the", "C1367657#ent", "<e1>", "or", "stabiliser", ",", "C0032285#ent", "<e2>", ",", "atelectasis", ",", "local", "infection", "pleural", "and", "pericardial", "effusion", "liver", "injury", "in", "11.1", "%", "of", "the", "patients", "."], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}}
{"token": ["Annexin", "II", "C1424250#ent", "<e1>", ")", "is", "a", "member", "of", "a", "family", "of", "C0072522#ent", "<e2>", "which", "bind", "negatively", "charged", "phospholipids", "in", "a", "calcium-dependent", "manner", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}}
{"token": ["The", "C1424250#ent", "<e1>", "holoreceptor", "is", "a", "C0072522#ent", "<e2>", "of", "Mr", "approximately", "125,000", "under", "non-denaturing", "conditions", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [6, 7]}}
{"token": ["Mean", "fluid", "requirements", "for", "C0011806#ent", "<e1>", "were", "one-half", "that", "for", "C0056562#ent", "<e2>", "during", "the", "24-h", "resuscitation", "period", "."], "h": {"id": "C0011806", "name": "C0011806#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0056562", "name": "C0056562#ent", "pos": [10, 11]}}
{"token": ["In", "the", "second", "stage", "of", "our", "study", "447", "teeth", "in", "C0011334#ent", "<e1>", "and", "pulpitis", "patients", "were", "treated", "using", "C1608295#ent", "<e2>", "based", "local", "anesthesia"], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1608295", "name": "C1608295#ent", "pos": [18, 19]}}
{"token": ["C0020452#ent", "<e1>", "regional", "myocardial", "perfusion", "was", "underestimated", "by", "C0919509#ent", "<e2>", "washout", "and", "severely", "ischemic", "regional", "myocardial", "perfusion", "was", "overestimated", "."], "h": {"id": "C0020452", "name": "C0020452#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [8, 9]}}
{"token": ["We", "suggest", "clinical", "or", "subclinical", "bacteraemic", "seeding", "of", "the", "C0277565#ent", "<e1>", "muscle", ",", "as", "the", "most", "likely", "mechanism", "for", "C0041188#ent", "<e2>", "."], "h": {"id": "C0277565", "name": "C0277565#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041188", "name": "C0041188#ent", "pos": [19, 20]}}
{"token": ["Substrate-specificity", "studies", "have", "revealed", "significant", "differences", "between", "TP", "and", "other", "C0031179#ent", "<e1>", "as", "well", "as", "similarities", "with", "class", "I", "C3178941#ent", "<e2>"], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3178941", "name": "C3178941#ent", "pos": [19, 20]}}
{"token": ["Post-therapeutic", "DNA", "biosynthesis", "was", "suppressed", "in", "mice", "given", "C0002260#ent", "<e1>", ",", "MGBG", "plus", "C0771987#ent", "<e2>", "."], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0771987", "name": "C0771987#ent", "pos": [13, 14]}}
{"token": ["These", "data", "suggest", "that", "a", "combination", "of", "MGBG", "with", "C0002260#ent", "<e1>", "leads", "to", "a", "favorable", "thermosensitization", "to", "the", "antitumor", "efficacy", "C0771987#ent", "<e2>", "."], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0771987", "name": "C0771987#ent", "pos": [20, 21]}}
{"token": ["Appetite", "improved", "in", "6", "cases", "and", "C0011168#ent", "<e1>", "disappeared", "in", "8", "cases", "after", "C0072916#ent", "<e2>", "P", "<", ".05", ")", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [13, 14]}}
{"token": ["C1517132#ent", "<e1>", "emerged", "as", "bona", "fide", "C0003392#ent", "<e2>", "the", "development", "of", "geranylgeranyl", "transferase", "inhibitors", "been", "mitigated", "by", "overt", "systemic", "toxicities"], "h": {"id": "C1517132", "name": "C1517132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [6, 7]}}
{"token": ["C1517132#ent", "<e1>", "FTIs", ")", "are", "novel", "C0003392#ent", "<e2>", "clinical", "activity"], "h": {"id": "C1517132", "name": "C1517132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [6, 7]}}
{"token": ["C1517132#ent", "<e1>", "FTIs", ")", "are", "C0003392#ent", "<e2>", "were", "designed", "to", "block", "the", "post-translational", "attachment", "of", "the", "prenyl", "moiety", "to", "C-terminal", "cysteine", "residue", "of", "Ras", "and", "thus", "inactivate", "it", "."], "h": {"id": "C1517132", "name": "C1517132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [5, 6]}}
{"token": ["As", "farnesylation", "of", "Ras", "protein", "farnesyltransferase", "is", "a", "critical", "step", "for", "Ras", "functional", "activity", "C1517132#ent", "<e1>", "FTI", ")", "have", "emerged", "as", "potential", "C0003392#ent", "<e2>"], "h": {"id": "C1517132", "name": "C1517132#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [22, 23]}}
{"token": ["The", "role", "of", "p38-", "and", "extracellular", "signal-regulated", "kinase", "C1705791#ent", "<e1>", ")", "mitogen-activated", "protein", "MAP", ")", "kinase", "pathways", "the", "up-regulation", "of", "C1533698#ent", "<e2>", "iNOS", ")", "and", "tumor", "necrosis", "factor", "TNF", ")", "production", "in", "macrophages", "stimulated", "with", "Streptococcus", "pneumoniae", "examined", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [20, 21]}}
{"token": ["Urocortin", "(", "UCN", ")", ",", "a", "member", "of", "the", "C1366488#ent", "<e1>", "CRF", ")", "family", "of", "peptides", "is", "a", "well", "described", "C0007209#ent", "<e2>"], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [20, 21]}}
{"token": ["Benzodiazepine", "(", "BDZ", ")", "agonists", "midazolam", "and", "diazepam", ",", "and", "the", "barbiturate", "pentobarbital", ",", "substituted", "for", "C0040879#ent", "<e1>", ",", "and", "the", "non-competitive", "N-methyl-D-aspartate", "NMDA", ")", "antagonist", "C0022614#ent", "<e2>", "did", "not", "."], "h": {"id": "C0040879", "name": "C0040879#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [26, 27]}}
{"token": ["These", "findings", "indicate", "that", "in", "C0036421#ent", "<e1>", "BAL", "neutrophilia", "is", "generally", "associated", "with", "C0010674#ent", "<e2>", "whereas", "a", "BAL", "eosinophilia", "is", "often", "seen", "in", "less", "advanced", "disease", "particularly", "when", "CT", "appearances", "suggest", "lung", "inflammation"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [13, 14]}}
{"token": ["Despite", "a", "relatively", "low", "sequence", "identity", "of", "approximately", "24", "%", ",", "the", "structure", "is", "highly", "C1512488#ent", "<e1>", "to", "that", "of", "B.cereus", "C3810542#ent", "<e2>", "with", "an", "r.m.s", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3810542", "name": "C3810542#ent", "pos": [21, 22]}}
{"token": ["to", "evaluate", "the", "prevalence", "of", "C0153188#ent", "<e1>", "delivery", "and", "neonatal", "C0039128#ent", "<e2>", "an", "Italian", "urban", "area", "in", "connection", "with", "the", "increased", "flow", "of", "immigration", "."], "h": {"id": "C0153188", "name": "C0153188#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [10, 11]}}
{"token": ["The", "etiology", "of", "C0018801#ent", "<e1>", "multiple", ",", "ranging", "from", "C0853897#ent", "<e2>", "structural", "modifications", "the", "heart", "following", "myocardial", "infarction", "long-standing", "high", "blood", "pressure"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0853897", "name": "C0853897#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "IL-5", "(", "E12", "K", ")", "is", "a", "full", "C2987634#ent", "<e1>", "in", "a", "human", "C0014457#ent", "<e2>", "survival", "assay", ",", "although", "with", "reduced", "potency", "compared", "to", "the", "wild-type", "protein"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [16, 17]}}
{"token": ["The", "capacities", "of", "physiologic", "soluble", "C2987634#ent", "<e1>", "to", "induce", "leukotriene", "C4", "LTC4", ")", "formation", "and", "C0014457#ent", "<e2>", "cationic", "protein", "release", "from", "normal", "human", "eosinophils", "were", "studied", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [15, 16]}}
{"token": ["C3714649#ent", "<e1>", "can", "be", "used", "to", "attenuate", "the", "production", "of", "C0812281#ent", "<e2>", "and", "potentially", "slow", "or", "stop", "the", "progression", "of", "renal", "disease"], "h": {"id": "C3714649", "name": "C3714649#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [10, 11]}}
{"token": ["We", "identified", "a", "19", "kDa", "band", "that", "corresponds", "to", "monomeric", "C1420276#ent", "<e1>", ",", "given", "its", "comigration", "with", "C1334043#ent", "<e2>", "human", "recombinant", "peptide", "well", "as", "with", "the", "protein", "extracted", "from", "cerebral", "cortex", "normal", "subjects"], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}}
{"token": ["Comparison", "of", "the", "results", "with", "those", "previously", "obtained", "for", "the", "Parkinson's", "disease-linked", "protein", "C1420276#ent", "<e1>", "shows", "that", "structural", "differences", "between", "the", "three", "C1334043#ent", "<e2>", "synuclein", "family", "members", "directly", "related", "to", "variations", "in", "their", "primary", "amino", "acid", "sequences"], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [22, 23]}}
{"token": ["The", "data", "indicate", "that", "the", "p170", "and", "C3539854#ent", "<e1>", "forms", "of", "C0012863#ent", "<e2>", "be", "distinguished", "biochemically", ",", "pharmacologically", ",", "and", "by", "differential", "cellular", "regulation"], "h": {"id": "C3539854", "name": "C3539854#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [11, 12]}}
{"token": ["The", "p170", "and", "C3539854#ent", "<e1>", "forms", "of", "C0012863#ent", "<e2>", "been", "compared", "."], "h": {"id": "C3539854", "name": "C3539854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [7, 8]}}
{"token": ["At", "-60", "mV", ",", "C2744579#ent", "<e1>", "induced", "an", "inward", "current", "(", "C1705021#ent", "<e2>", ",", "C2744579#ent", "<e1>", ")", "that", "peaked", "within", "0.4", "s", "and", "then", "decayed", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705021", "name": "C1705021#ent", "pos": [11, 12]}}
{"token": ["The", "NAD-specific", "glyceraldehyde-3-phosphate", "dehydrogenase", "C3536868#ent", "<e1>", "was", "purified", "from", "Spinacia", "oleracea", "Pisum", "sativum", "affinity", "chromatography", "C0106651#ent", "<e2>"], "h": {"id": "C3536868", "name": "C3536868#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0106651", "name": "C0106651#ent", "pos": [15, 16]}}
{"token": ["Prolyl", "endopeptidases", "C1846609#ent", "<e1>", ")", "are", "a", "unique", "class", "of", "C2717971#ent", "<e2>", "considerable", "therapeutic", "potential", "for", "the", "treatment", "of", "celiac", "sprue"], "h": {"id": "C1846609", "name": "C1846609#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [10, 11]}}
{"token": ["The", "cytotoxic", "effects", "AGEs", "could", "be", "attenuated", "by", "C1291208#ent", "<e1>", "and", "pyruvate", ",", "by", "antioxidants", "such", "as", "thioctic", "acid", "C0001047#ent", "<e2>", ",", "and", "by", "aminoguanidine", ",", "an", "inhibitor", "of", "nitric", "oxide", "synthase"], "h": {"id": "C1291208", "name": "C1291208#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [19, 20]}}
{"token": ["The", "success", "of", "anti-HIV-1", "therapy", "inhibitors", "specifically", "targeting", "HIV", "RT", "suggests", "that", "other", "C0035681#ent", "<e1>", "be", "the", "valid", "molecular", "targets", "the", "design", "of", "C0013227#ent", "<e2>"], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [23, 24]}}
{"token": ["Several", "C0764430#ent", "<e1>", "undergone", "clinical", "trials", "potential", "C0013227#ent", "<e2>"], "h": {"id": "C0764430", "name": "C0764430#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}}
{"token": ["A", "double-blind", "controlled", "trial", "10", "subjects", "with", "laboratory", "animal-induced", "bronchospasm", "showed", "that", "prior", "use", "of", "C0086073#ent", "<e1>", "offered", "considerable", "or", "complete", "protection", "against", "both", "immediate", "and", "C0006266#ent", "<e2>", "all", "subjects", "but", "one", "."], "h": {"id": "C0086073", "name": "C0086073#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [26, 27]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "identify", "the", "role", "of", "leukotriene", "B4", "LTB4", ")", "and", "platelet", "activating", "factor", "C0235480#ent", "<e1>", ")", "in", "the", "pathogenesis", "of", "C0751039#ent", "<e2>", "GO", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [27, 28]}}
{"token": ["Treatment", "of", "C0024141#ent", "<e1>", "platelet-rich", "plasma", "with", "C0011522#ent", "<e2>", "(", "DNase", ")", "resulted", "in", "enhancement", "of", "collagen-induced", "aggregation", "4", "group", "I", "C0024141#ent", "<e1>", "patients", ",", "but", "not", "in", "1", "group", "II", "8", "normal", "individuals", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [7, 8]}}
{"token": ["Antibody", "to", "DNA", "was", "measured", "before", "and", "after", "treatment", "of", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e1>", ")", "sera", "with", "C0011522#ent", "<e2>", "DNase", "I", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [18, 19]}}
{"token": ["Complementary", "DNA", "cloning", "the", "human", "C0033713#ent", "<e1>", "a", "receptor", "tyrosine", "kinase", "this", "possibility", ":", "C1704888#ent", "<e2>", "encodes", "a", "transmembrane", "glycoprotein", "is", "structurally", "related", "to", "the", "receptor", "for", "macrophage", "growth", "factor", "CSF-1", ")", "and", "the", "receptor", "for", "platelet-derived", "growth", "factor"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704888", "name": "C1704888#ent", "pos": [14, 15]}}
{"token": ["In", "neutrophils", "and", "platelets", "neither", "5(S)-hydroxyeicosatetraenoic", "acid", "12(S)-hydroxyeicosatetraenoic", "acid", ",", "nor", "leukotriene", "C4", "formation", "reduced", ",", "indicating", "selective", "inhibition", "of", "C1416927#ent", "<e1>", "not", "5-lipoxygenase", ",", "12-lipoxygenase", ",", "or", "C0003693#ent", "<e2>"], "h": {"id": "C1416927", "name": "C1416927#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [28, 29]}}
{"token": ["These", "results", "suggest", "that", "MSS4", "and", "C1419206#ent", "<e1>", "GRF", "are", "different", "C1366909#ent", "<e2>", "C1419206#ent", "<e1>", "."], "h": {"id": "C1419206", "name": "C1419206#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366909", "name": "C1366909#ent", "pos": [11, 12]}}
{"token": ["If", "cytoskeletons", "are", "further", "extracted", "with", "Tsb", "containing", "250", "mM", "ammonium", "sulfate", "C1134548#ent", "<e1>", ")", ",", "fixation", "with", "formaldehyde", "or", "C0001957#ent", "<e2>", "has", "reduced", "or", "no", "effect", "the", "binding", "of", "Tp-GFAP1", "."], "h": {"id": "C1134548", "name": "C1134548#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001957", "name": "C0001957#ent", "pos": [20, 21]}}
{"token": ["C0919550#ent", "<e1>", "is", "one", "of", "seven", "proprotein", "convertase", "family", "members", "promote", "proteolytic", "maturation", "C1709708#ent", "<e2>", "."], "h": {"id": "C0919550", "name": "C0919550#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1709708", "name": "C1709708#ent", "pos": [13, 14]}}
{"token": ["We", "found", "that", "Ser-132", "of", "C1417108#ent", "<e1>", "was", "specifically", "phosphorylated", "by", "C0010536#ent", "<e2>", "addition", ",", "Western", "blotting", "an", "antiserum", "against", "C1417108#ent", "<e1>", "and", "in-gel", "staining", "for", "phosphorylated", "proteins", "that", "C1417108#ent", "<e1>", "is", "phosphorylated", "in", "vivo"], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417108", "name": "C1417108#ent", "pos": [5, 6]}}
{"token": ["In", "addition", ",", "the", "binding", "assays", "suggested", "that", "the", "C0812382#ent", "<e1>", "different", "from", "cAMP-response", "element", "binding", "protein", "C1705055#ent", "<e2>", ")", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705055", "name": "C1705055#ent", "pos": [17, 18]}}
{"token": ["Since", "IFNs", "suppress", "cell", "growth", "inhibition", "of", "endogenous", "IFN-beta", "synthesis", "may", "also", "be", "responsible", "for", "the", "amplification", "by", "C0011777#ent", "<e1>", "of", "the", "C1332817#ent", "<e2>", "TNF", "and", "IL-1", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332817", "name": "C1332817#ent", "pos": [22, 23]}}
{"token": ["Pithing", ",", "C0035179#ent", "<e1>", "treatment", "and", "ganglionic", "blockade", "C0062637#ent", "<e2>", "(", "5", "mg/kg", ")", "enhanced", "the", "effect", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0062637", "name": "C0062637#ent", "pos": [8, 9]}}
{"token": ["This", "unique", "case", "extends", "the", "clinical", "spectrum", "AHC", "to", "include", "C0001403#ent", "<e1>", "adulthood", "and", "milder", "forms", "of", "C0342482#ent", "<e2>", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0342482", "name": "C0342482#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "we", "showed", "that", "the", "expression", "of", "Dnajb13", "mRNA", "and", "C1415791#ent", "<e1>", "unaltered", "after", "heat", "shock", "treatment", ",", "indicating", "that", "C1415791#ent", "<e1>", "was", "constitutively", "expressed", "in", "mouse", "testis"], "h": {"id": "C1415791", "name": "C1415791#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415791", "name": "C1415791#ent", "pos": [12, 13]}}
{"token": ["Six", "weeks", "later", ",", "he", "developed", "C0043195#ent", "<e1>", "associated", "with", "severe", "anemia", "of", "C1561643#ent", "<e2>"], "h": {"id": "C0043195", "name": "C0043195#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [13, 14]}}
{"token": ["C1332080#ent", "<e1>", "diffuse", "large", "B-cell", "lymphoma", "DLBCL", ")", "is", "an", "unusual", "C0029896#ent", "<e2>", "reported", "in", "1997", "as", "DLBCL", "with", "expression", "of", "full-length", "ALK", "protein", "."], "h": {"id": "C1332080", "name": "C1332080#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "percutaneous", "transluminal", "coronary", "angioplasty", "a", "safe", "and", "successful", "procedure", "in", "patients", "with", "C0002965#ent", "<e1>", "well", "as", "in", "patients", "with", "C0340288#ent", "<e2>"], "h": {"id": "C0002965", "name": "C0002965#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "CRP", "may", "be", "less", "predictive", "of", "long-term", "outcomes", "when", "measured", "after", "acute", "myocardial", "infarction", "AMI", ")", "than", "after", "C0002965#ent", "<e1>", "UAP", ")", "or", "C0340288#ent", "<e2>", "SAP", ")", "."], "h": {"id": "C0002965", "name": "C0002965#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [25, 26]}}
{"token": ["Herein", "we", "report", "that", "the", "inhibition", "of", "C1538842#ent", "<e1>", "decreases", "the", "expression", "of", "the", "important", "antiapoptotic", "proteins", "C1366587#ent", "<e2>", "and", "XIAP", "accompanied", "by", "a", "loss", "of", "the", "mitochondrial", "membrane", "potential", "."], "h": {"id": "C1538842", "name": "C1538842#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366587", "name": "C1366587#ent", "pos": [17, 18]}}
{"token": ["However", ",", "C1738762#ent", "<e1>", "exhibits", "potent", "C0003392#ent", "<e2>", "and", "apoptotic", "effects", "cancer", "cells", "proliferation", "is", "dependent", "on", "mutant", "kinases", "such", "as", "FLT3", "."], "h": {"id": "C1738762", "name": "C1738762#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [6, 7]}}
{"token": ["C1738762#ent", "<e1>", "is", "not", "a", "general", "C0003392#ent", "<e2>", ",", "in", "most", "cancer", "cells", ">", "1,000-fold", "higher", "concentrations", "of", "C1738762#ent", "<e1>", "are", "required", "for", "inhibition", "of", "proliferation", "."], "h": {"id": "C1738762", "name": "C1738762#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [6, 7]}}
{"token": ["C0030956#ent", "<e1>", "thymalin--0.2", "mlg/mice", "intraperitoneally", ")", "suppressed", "the", "C1951340#ent", "<e2>", "of", "forming", "DHE", "irrespective", "of", "mice", "line", "improved", "the", "C1951340#ent", "<e2>", "of", "its", "consolidation", "and", "keeping", "especially", "in", "mice", "MRL/1", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1951340", "name": "C1951340#ent", "pos": [8, 9]}}
{"token": ["The", "C0026946#ent", "<e1>", "sporotrichosis", ",", "pityrosporum", "folliculitis", "zygomycosis", ",", "candidiasis", ",", "aspergillosis", "and", "C0005716#ent", "<e2>", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0005716", "name": "C0005716#ent", "pos": [13, 14]}}
{"token": ["In", "combination", "with", "amphotericin", "B", "5-FC", "can", "be", "used", "to", "treat", "severe", "C0026946#ent", "<e1>", "such", "as", "cryptococcosis", ",", "candidosis", ",", "C0005716#ent", "<e2>", "and", "aspergillosis", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0005716", "name": "C0005716#ent", "pos": [20, 21]}}
{"token": ["In", "a", "53-year-old", "woman", "an", "acute", "allergic", "thrombocytopenia", "C0398650#ent", "<e1>", "occurred", "after", "treatment", "with", "C0030817#ent", "<e2>", "for", "one", "month", "which", "led", "to", "death", "."], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [14, 15]}}
{"token": ["The", "most", "lipophilic", "effects", "observed", "with", "octyldodecanol", "and", "C0001962#ent", "<e1>", "the", "vehicles", "(", "or", "co-vehicles", ")", ",", "coconut", "oil", "C0064161#ent", "<e2>", "safflower", "oil", "botanical", "oils"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0064161", "name": "C0064161#ent", "pos": [19, 20]}}
{"token": ["A", "new", "family", "of", "related", "C0001473#ent", "<e1>", "has", "emerged", ",", "characterized", "by", "a", "highly", "conserved", "C0162871#ent", "<e2>", "motif", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162871", "name": "C0162871#ent", "pos": [15, 16]}}
{"token": ["The", "specific", "ATPase", "activity", "C1420706#ent", "<e1>", "was", "more", "than", "twice", "that", "of", "C1417838#ent", "<e2>", ",", "and", "hybrid", "enzymes", "containing", "the", "beta", "subunit", "C1420706#ent", "<e1>", "had", "higher", "activity", "than", "other", "hybrids", "."], "h": {"id": "C1420706", "name": "C1420706#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417838", "name": "C1417838#ent", "pos": [12, 13]}}
{"token": ["Fourteen", "ivi", "(", "for", "in", "vivo", "induced", ")", "C0017337#ent", "<e1>", "that", "are", "induced", "during", "infection", "in", "a", "C0000833#ent", "<e2>", "model", "were", "identified", "in", "our", "study", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [17, 18]}}
{"token": ["mRNA", "transcripts", "detected", "from", "three", "hgl", "genes", "and", "three", "lgl", "C0017337#ent", "<e1>", ",", "with", "no", "significant", "between", "cultured", "amoebae", "and", "amoebae", "from", "C0000833#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [22, 23]}}
{"token": ["Ectopic", "expression", "of", "C1419245#ent", "<e1>", "or", "human", "C1448657#ent", "<e2>", "complemented", "Mrad9(-/-", ")", "cell", "defects", ",", "indicating", "that", "the", "gene", "has", "radioresponse", "and", "genomic", "maintenance", "that", "are", "evolutionarily", "conserved", "."], "h": {"id": "C1419245", "name": "C1419245#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1448657", "name": "C1448657#ent", "pos": [7, 8]}}
{"token": ["Dantrolene", "also", "has", "been", "utilized", "successfully", "in", "C1744687#ent", "<e1>", "on", "the", "hypothesis", "that", "the", "C1848862#ent", "<e2>", "is", "similar", "to", "anesthetic-induced", "malignant", "hyperthermia", "."], "h": {"id": "C1744687", "name": "C1744687#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [14, 15]}}
{"token": ["The", "neuroleptic", "malignant", "syndrome", "C1744687#ent", "<e1>", ")", "is", "a", "potentially", "fatal", "C1848862#ent", "<e2>", "characterized", "by", "diffuse", "muscular", "rigidity", "pyrexia", ",", "sweating", ",", "cardiovascular", "instability", "and", "elevated", "serum", "creatinine", "phosphokinase"], "h": {"id": "C1744687", "name": "C1744687#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [11, 12]}}
{"token": ["Our", "study", "thus", "suggests", "that", "the", "combined", "use", "of", "SK", "and", "anticonvulsants", "such", "as", "barbiturates", "and", "C0005064#ent", "<e1>", "may", "be", "more", "effective", "in", "treating", "C0234533#ent", "<e2>", "patients", "than", "SK", "alone", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [24, 25]}}
{"token": ["Treatment", "is", "based", "upon", "avoidance", "of", "fasting", "and/or", "exercise", ",", "a", "low-fat", "diet", "with", "C0724624#ent", "<e1>", "carnitine", "(", "\"", "severe", "\"", "C1829703#ent", "<e2>", "."], "h": {"id": "C0724624", "name": "C0724624#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1829703", "name": "C1829703#ent", "pos": [21, 22]}}
{"token": ["This", "C0013227#ent", "<e1>", "increased", "the", "intestinal", "fatty-acid-binding-protein", "(", "I-FABPc", ")", "and", "C1333524#ent", "<e2>", "L-FABPc", ")", "mRNA", "levels", "in", "the", "duodenum", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333524", "name": "C1333524#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "suggest", "that", "C1417487#ent", "<e1>", "may", "affect", "C1522428#ent", "<e2>", "production", "and", "C1522428#ent", "<e2>", "mediated", "events", "in", "some", "patients", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "methotrexate", "(", "C1417487#ent", "<e1>", ")", "treatment", "on", "patients", "with", "rheumatoid", "arthritis", "interleukin", "1", "C1522428#ent", "<e2>", ")", "was", "evaluated", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [16, 17]}}
{"token": ["GHR", "metalloproteolysis", "can", "be", "catalyzed", "by", "C0529196#ent", "<e1>", "ADAM-17", ")", "and", "is", "associated", "with", "of", "C3539616#ent", "<e2>", "signaling", "."], "h": {"id": "C0529196", "name": "C0529196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [15, 16]}}
{"token": ["Kinetic", "data", "that", "the", "interaction", "of", "both", "C0795749#ent", "<e1>", "and", "verapamil", "with", "the", "C0220821#ent", "<e2>", "not", "cooperative", "."], "h": {"id": "C0795749", "name": "C0795749#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0220821", "name": "C0220821#ent", "pos": [13, 14]}}
{"token": ["Plasma", "and", "lipoprotein", "distribution", "of", "cholesterol", "and", "triglycerides", "were", "measured", "in", "experimentally", "induced", "hypercholesterolemia", "associated", "with", "moderate", "C0020676#ent", "<e1>", "and", "after", "Anna", "Pavala", "Sindhooram", "C1333570#ent", "<e2>", ")", "therapy", "in", "rat", "models", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [24, 25]}}
{"token": ["Endothelial", "dysfunction", "C0020443#ent", "<e1>", "improved", "by", "treatment", "with", "atorvastatin", "or", "simvastatin", "plus", "C0008402#ent", "<e2>", "and", "this", "effect", "may", "result", "in", "the", "prevention", "of", "future", "coronary", "events"], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [12, 13]}}
{"token": ["In", "severe", "primary", "C0020443#ent", "<e1>", "combination", "therapy", "lovastatin", "and", "a", "resin", "such", "as", "C0008402#ent", "<e2>", "is", "required", "to", "obtain", "total", "cholesterol", "values", "5.2", "mmol/l", "."], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [13, 14]}}
{"token": ["Stigmasterol", ",", "which", "differs", "from", "beta-sitosterol", "by", "unsaturation", "at", "C22", ",", "was", "tested", "for", "C0020443#ent", "<e1>", "an", "experimental", "protocol", "gave", "the", "results", "expected", "with", "beta-sitosterol", "and", "C0008402#ent", "<e2>", "."], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [26, 27]}}
{"token": ["C0265291#ent", "<e1>", "a", "rare", "C0039082#ent", "<e2>", "characterized", "by", "growth", "retardation", "uniformly", "small", "slender", "long", "bones", "with", "medullary", "stenosis", "thickened", "cortex", "the", "long", "bones", "hypocalcemia", "possibly", "with", "tetany", "at", "an", "early", "age", "hyperphosphatemia", ",", "ocular", "abnormalities", "and", "normal", "intelligence"], "h": {"id": "C0265291", "name": "C0265291#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [4, 5]}}
{"token": ["The", "molecular", "mechanisms", "increased", "C0251211#ent", "<e1>", "PEPCK", ")", "gene", "transcription", "gluconeogenesis", "in", "C0011860#ent", "<e2>", "largely", "unknown", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}}
{"token": ["We", "sequenced", "the", "promoter", "and", "coding", "regions", "PCK1", "encoding", "C0251211#ent", "<e1>", "genomic", "DNA", "subjects", "with", "C0011860#ent", "<e2>", "DM", ")", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [15, 16]}}
{"token": ["However", ",", "other", "C0001046#ent", "<e1>", "galantamine", "and", "tacrine", ")", "and", "NMDA", "receptor", "antagonists", "memantine", "and", "C0079245#ent", "<e2>", "(", "MK801", ")", ")", "did", "not", "significantly", "decrease", "LDH", "release", "."], "h": {"id": "C0001046", "name": "C0001046#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079245", "name": "C0079245#ent", "pos": [15, 16]}}
{"token": ["Excitotoxicity", ",", "mitochondrial", "dysfunction", "free", "radical", "induced", "oxidative", "damage", "have", "been", "implicated", "in", "the", "pathogenesis", "of", "several", "different", "C0524851#ent", "<e1>", "such", "as", "C1862939#ent", "<e2>", "Parkinson's", "disease", "PD", ")", ",", "Alzheimer's", "disease", "AD", ")", ",", "and", "Huntington's", "disease"], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1862939", "name": "C1862939#ent", "pos": [22, 23]}}
{"token": ["These", "data", "confirmed", "pituitary", "dysfunction", "the", "basic", "defect", "caused", "by", "the", "mutation", "lit", "showed", "that", "the", "C0162429#ent", "<e1>", "responsible", "for", "C0878787#ent", "<e2>"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0878787", "name": "C0878787#ent", "pos": [20, 21]}}
{"token": ["Previously", ",", "we", "have", "shown", "that", "the", "rise", "of", "intracellular", "calcium", "through", "excitatory", "glutamate", "receptors", "N-methyl-d-aspartate", "(", "C0022614#ent", "<e1>", ")", "and", "non-NMDA-type", "channels", "stimulates", "C3811152#ent", "<e2>", "synthesis", "in", "the", "cockroach", ",", "Diploptera", "punctata"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3811152", "name": "C3811152#ent", "pos": [24, 25]}}
{"token": ["Knockdown", "of", "C1706553#ent", "<e1>", "inhibited", "the", "Rab13-independent", "transport", "of", "C0694872#ent", "<e2>", "to", "the", "PM", "."], "h": {"id": "C1706553", "name": "C1706553#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [9, 10]}}
{"token": ["The", "genomic", "structure", "the", "murine", "C0812307#ent", "<e1>", "that", "the", "two", "types", "of", "C1442804#ent", "<e2>", "transcripts", "are", "derived", "from", "alternative", "splicing", "utilizing", "an", "internal", "splice", "donor", "site", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [12, 13]}}
{"token": ["The", "corresponding", "appearance", "of", "the", "C0812307#ent", "<e1>", "expression", "and", "the", "formation", "of", "Purkinje", "cell", "dendritic", "arbors", "that", "C1442804#ent", "<e2>", "involved", "in", "dendrogenesis", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [17, 18]}}
{"token": ["These", "include", "polycystic", "ovary", "syndrome", "PCOS", ")", ",", "isolated", "components", "of", "this", "C0039082#ent", "<e1>", "such", "as", "C0032460#ent", "<e2>", "hyperandrogenaemia", ",", "hypothalamic", "amenorrhoea", "and", "functional", "hyperprolactinaemia", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [16, 17]}}
{"token": ["The", "C0039082#ent", "<e1>", "is", "characterized", "by", "a", "combination", "of", "C0032460#ent", "<e2>", "morphology", ",", "clinical", "features", "and", "biochemical", "indices"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [9, 10]}}
{"token": ["The", "current", "consensus", "on", "diagnostic", "criteria", "polycystic", "ovary", "syndrome", "concluded", "that", "it", "is", "a", "C0039082#ent", "<e1>", "of", "ovarian", "dysfunction", "with", "hyperandrogenism", "and", "morphology", "of", "C0032460#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [24, 25]}}
{"token": ["Both", "the", "GABAergic", "agonist", "C0026818#ent", "<e1>", ",", "and", "the", "C2936795#ent", "<e2>", "clonidine", ",", "were", "found", "to", "reduce", "the", "amplitude", "of", "the", "P13", "potential", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936795", "name": "C2936795#ent", "pos": [9, 10]}}
{"token": ["Intraocular", "pressures", "recorded", "after", "the", "administration", "of", "C0012792#ent", "<e1>", "and", "endotracheal", "intubation", "a", "series", "of", "20", "patients", "who", "had", "not", "received", "C0030311#ent", "<e2>", "4", "min", "before", "the", "C0012792#ent", "<e1>", "."], "h": {"id": "C0030311", "name": "C0030311#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [7, 8]}}
{"token": ["Intubation", "was", "facilitated", "with", "2", "mg", "C0030311#ent", "<e1>", "and", "50", "-", "100", "mg", "C0012792#ent", "<e2>", "."], "h": {"id": "C0030311", "name": "C0030311#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [13, 14]}}
{"token": ["Germ", "line", "mutations", "one", "C0002085#ent", "<e1>", "of", "the", "C1704885#ent", "<e2>", "proto-oncogene", "predispose", "to", "the", "multiple", "endocrine", "neoplasia", "type", "2", "MEN", "2", "syndromes", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704885", "name": "C1704885#ent", "pos": [8, 9]}}
{"token": ["We", "have", "analyzed", "the", "expression", "of", "ELN", "C0002085#ent", "<e1>", "in", "skin", "fibroblasts", "one", "SVAS", "patient", "and", "shown", "that", "C1704885#ent", "<e2>", "mutations", "indeed", "result", "in", "selective", "elimination", "of", "mutant", "transcripts", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704885", "name": "C1704885#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "show", "that", "B-cell", "receptor", "C0105421#ent", "<e1>", ")", "engagement", "triggers", "C3714973#ent", "<e2>", "phosphorylation", "and", "nuclear", "export", "FOXO1", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3714973", "name": "C3714973#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "provide", "evidence", "that", "coligation", "of", "FcgammaRIIb1", "with", "C0105421#ent", "<e1>", "induces", "binding", "of", "C3714973#ent", "<e2>", "SHIP", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714973", "name": "C3714973#ent", "pos": [17, 18]}}
{"token": ["Expression", "of", "C1422205#ent", "<e1>", "in", "adult", "human", "duct", "cells", "induced", "Notch", "ligands", "Dll1", "and", "C1414072#ent", "<e2>", "and", "neuroendocrine-", "and", "beta-cell-specific", "markers", ":", "it", "increased", "the", "percentage", "of", "synaptophysin-", "and", "cells", "15-fold", "in", "ngn3-infected", "versus", "control", "cells"], "h": {"id": "C1422205", "name": "C1422205#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414072", "name": "C1414072#ent", "pos": [14, 15]}}
{"token": ["Under", "these", "conditions", ",", "Glu-", "and", "K(+)-induced", "accumulations", "of", "C1968833#ent", "<e1>", "are", "inhibited", ",", "whereas", "the", "C0006945#ent", "<e2>", "(Carb)-elicited", "response", "of", "C1968833#ent", "<e1>", "parallels", "the", "basal", "one", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [9, 10]}}
{"token": ["C0729584#ent", "<e1>", "adults", "was", "reviewed", "to", "establish", "the", "frequency", "of", "C0025297#ent", "<e2>", "due", "to", "each", "causative", "agent", "to", "reexamine", "the", "laboratory", "parameters", "that", "help", "to", "distinguish", "aseptic", ",", "bacterial", ",", "and", "mycobacterial", "meningitis"], "h": {"id": "C0729584", "name": "C0729584#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [10, 11]}}
{"token": ["Consistent", "with", "these", "facts", ",", "the", "frequent", "expression", "of", "C3273507#ent", "<e1>", "and", "hsp90N", "on", "the", "surface", "of", "colorectal", "cancer", "cells", "enable", "C3273507#ent", "<e1>", "to", "act", "as", "a", "mediator", "of", "metastasis", "generation", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [9, 10]}}
{"token": ["Consistent", "with", "these", "facts", ",", "the", "frequent", "expression", "of", "hsp90alpha", "and", "C3273507#ent", "<e1>", "on", "the", "surface", "of", "colorectal", "cancer", "cells", "enable", "C3273507#ent", "<e1>", "to", "act", "as", "a", "mediator", "of", "metastasis", "generation", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "twice", "daily", "inhalation", "therapy", "C0004906#ent", "<e1>", "is", "recommended", "for", "C0004096#ent", "<e2>", "patients", "."], "h": {"id": "C0004906", "name": "C0004906#ent", "pos": [6, 7]}, "relation": "may_prevent", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}}
{"token": ["From", "April", "1992", "we", "introduced", "C0004906#ent", "<e1>", "BDP", ")", "inhalation", "therapy", "a", "large", "spacer", "for", "patients", "with", "C0004096#ent", "<e2>", "were", "admitted", "to", "the", "internal", "medicine", "department", "our", "hospital", "because", "of", "an", "exacerbation", "of", "asthma", "."], "h": {"id": "C0004906", "name": "C0004906#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "evaluate", "the", "effect", "of", "C3887685#ent", "<e1>", "genotype", "(", "specifically", "the", "CYP2D6*10", "allele", "on", "the", "pharmacokinetics", "of", "C0065180#ent", "<e2>", "in", "Chinese", "subjects", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [11, 12]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0065180", "name": "C0065180#ent", "pos": [23, 24]}}
{"token": ["Fusicoccin", "(", "FC", ")", "is", "commonly", "thought", "to", "promote", "\"", "electrogenic", "\"", "C0018440#ent", "<e1>", "through", "its", "action", "on", "the", "C0379099#ent", "<e2>", "of", "the", "plant", "plasma", "membrane"], "h": {"id": "C0018440", "name": "C0018440#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [19, 20]}}
{"token": ["When", "only", "the", "carboxyl-terminal", "arginine", "removed", "with", "C0007075#ent", "<e1>", "however", ",", "the", "C0030956#ent", "<e2>", "loses", "its", "adsorptive", "ability", "."], "h": {"id": "C0007075", "name": "C0007075#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["Initial", "treatment", "with", "C0008269#ent", "<e1>", "and", "20", "or", "40", "mg/kg", "of", "C0033405#ent", "<e2>", "cleared", "parasitemia", "in", "some", "animals", "followed", "by", "recrudescence", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033405", "name": "C0033405#ent", "pos": [11, 12]}}
{"token": ["Drugs", "used", "for", "hyperuricemia", "and", "C0018099#ent", "<e1>", "such", "as", "colchicine", ",", "allopurinol", ",", "C0033209#ent", "<e2>", ",", "and", "sulphinpyrazone", "have", "not", "been", "implicated", "in", "affecting", "exercise", "performance", "."], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [13, 14]}}
{"token": ["Infected", "C0162872#ent", "<e1>", "be", "complicated", "by", "C0085222#ent", "<e2>"], "h": {"id": "C0162872", "name": "C0162872#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085222", "name": "C0085222#ent", "pos": [6, 7]}}
{"token": ["Phenylketonuria", "(", "C0031485#ent", "<e1>", ")", "is", "the", "most", "common", "of", "all", "C0002514#ent", "<e2>", "and", "is", "caused", "by", "autosomal", "recessive", "deficiency", "the", "hepatic", "phenylalanine", "hydroxylase", "system"], "h": {"id": "C0031485", "name": "C0031485#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0002514", "name": "C0002514#ent", "pos": [11, 12]}}
{"token": ["C0031485#ent", "<e1>", "(", "PKU", ")", "is", "the", "most", "common", "of", "all", "C0002514#ent", "<e2>", "and", "is", "caused", "by", "autosomal", "recessive", "deficiency", "the", "hepatic", "phenylalanine", "hydroxylase", "system"], "h": {"id": "C0031485", "name": "C0031485#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0002514", "name": "C0002514#ent", "pos": [11, 12]}}
{"token": ["The", "competitive", "NMDA", "antagonist", ",", "C0754188#ent", "<e1>", ",", "and", "the", "C0815027#ent", "<e2>", "MK-801", "and", "ketamine", ",", "all", "caused", "a", "pronounced", "reduction", "in", "VOR", "gain", "."], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0815027", "name": "C0815027#ent", "pos": [10, 11]}}
{"token": ["The", "C1413043#ent", "<e1>", "values", "in", "CSF", "samples", "from", "13", "patients", "with", "C1417325#ent", "<e2>", "higher", "than", "those", "in", "CSF", "samples", "from", "11", "patients", "with", "various", "peripheral", "neurological", "disorders"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [11, 12]}}
{"token": ["Double", "stranded", "cDNA", "synthesized", "using", "AMV", "reverse", "transcriptase", "E.", "coli", "C0012888#ent", "<e1>", "tailed", "using", "C1333243#ent", "<e2>", "inserted", "into", "the", "Pst", "I", "site", "of", "pBR322", "."], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333243", "name": "C1333243#ent", "pos": [14, 15]}}
{"token": ["Multidetector", "row", "computed", "tomography", "MDCT", ")", "imaging", "of", "the", "aorta", "is", "used", "to", "diagnose", "various", "acute", "and", "C3266262#ent", "<e1>", "including", "aortic", "aneurysms", "aortic", "dissection", "intramural", "hematoma", "penetrating", "atherosclerotic", "ulcer", "traumatic", "injury", "rupture", ",", "C1290884#ent", "<e2>", "and", "congenital", "malformations"], "h": {"id": "C3266262", "name": "C3266262#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [33, 34]}}
{"token": ["The", "strictures", "occurred", "after", "anastomosis", "in", "seven", "patients", ",", "with", "carcinoma", "in", "four", "patients", ",", "and", "with", "C0029400#ent", "<e1>", "external", "compression", ",", "and", "C0039263#ent", "<e2>", "in", "one", "patient", "each", "."], "h": {"id": "C0029400", "name": "C0029400#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0039263", "name": "C0039263#ent", "pos": [23, 24]}}
{"token": ["When", "patients", "suffer", "from", "C0019151#ent", "<e1>", ",", "(cardio)myopathy", ",", "dystrophy", ",", "hypoglycaemia", ",", "some", "C0005944#ent", "<e2>", "several", "other", "disease", "states", "carnitine", "deficiency", "be", "considered", "."], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [14, 15]}}
{"token": ["Once", "released", ",", "cytosolic", "C1825552#ent", "<e1>", "causes", "X-chromosome-linked", "inhibitor", "of", "C3537312#ent", "<e2>", "XIAP", ")", "degradation", ",", "caspase", "activation", "and", "subsequent", "apoptosis", "."], "h": {"id": "C1825552", "name": "C1825552#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537312", "name": "C3537312#ent", "pos": [10, 11]}}
{"token": ["These", "findings", "suggest", "that", "the", "C0016429#ent", "<e1>", "able", "to", "respond", "to", "C0016424#ent", "<e2>", ",", "inducing", "structural", "changes", "in", "the", "ovarian", "cortex", "well", "as", "in", "the", "subcortical", "medulla", "."], "h": {"id": "C0016429", "name": "C0016429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "C0016429#ent", "<e1>", "development", "can", "not", "progress", "beyond", "the", "preantral", "stage", "without", "C0016424#ent", "<e2>", "."], "h": {"id": "C0016429", "name": "C0016429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [14, 15]}}
{"token": ["The", "apo-form", "of", "A4V", "C0669516#ent", "<e1>", "was", "highly", "reactive", "with", "C1870389#ent", "<e2>", "but", "not", "C0669516#ent", "<e1>", "containing", "both", "copper", "and", "zinc", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1870389", "name": "C1870389#ent", "pos": [10, 11]}}
{"token": ["Gleevec", ",", "a", "known", "C1268567#ent", "<e1>", "has", "been", "shown", "to", "lower", "C1705543#ent", "<e2>", "secretion", ",", "and", "it", "is", "considered", "a", "potential", "basis", "for", "novel", "therapies", "for", "Alzheimer's", "disease"], "h": {"id": "C1268567", "name": "C1268567#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [11, 12]}}
{"token": ["These", "results", "demonstrate", "that", "C1863512#ent", "<e1>", "must", "bind", "the", "C1366529#ent", "<e2>", "tail", "and", "either", "clathrin", "or", "AP-2", "to", "promote", "receptor", "clustering", "and", "internalization", "of", "LDL", "."], "h": {"id": "C1863512", "name": "C1863512#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366529", "name": "C1366529#ent", "pos": [9, 10]}}
{"token": ["Rad2", "(", "a", "single-stranded", "DNA", "endonuclease", "specifically", "interacts", "with", "the", "Tfb1", "subunit", "of", "C1824728#ent", "<e1>", "and", "we", "have", "mapped", "a", "limited", "region", "of", "the", "C1305923#ent", "<e2>", "is", "sufficient", "for", "this", "interaction", "."], "h": {"id": "C1824728", "name": "C1824728#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [24, 25]}}
{"token": ["The", "C1824728#ent", "<e1>", "preparation", "consisted", "of", "two", "major", "C1305923#ent", "<e2>", "(", "11,000", "and", "18,000", ")", "."], "h": {"id": "C1824728", "name": "C1824728#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}}
{"token": ["C0340427#ent", "<e1>", "possessed", "actin", ",", "tubulin", "and", "C1421451#ent", "<e2>", ",", "but", "neither", "desmin", "nor", "cytokeratin", "."], "h": {"id": "C0340427", "name": "C0340427#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421451", "name": "C1421451#ent", "pos": [7, 8]}}
{"token": ["This", "study", "was", "designed", "to", "compare", "the", "effectiveness", "of", "ondansetron", ",", "C0061863#ent", "<e1>", ",", "and", "dexamethasone", "for", "the", "prevention", "of", "C0520909#ent", "<e2>", "in", "patients", "after", "laparoscopic", "cholecystectomy"], "h": {"id": "C0061863", "name": "C0061863#ent", "pos": [11, 12]}, "relation": "may_prevent", "t": {"id": "C0520909", "name": "C0520909#ent", "pos": [20, 21]}}
{"token": ["To", "evaluate", "the", "antiemetic", "efficacy", "of", "C0061863#ent", "<e1>", ",", "a", "selective", "5-hydroxytryptamine", "type", "3", "receptor", "antagonist", "on", "C0520909#ent", "<e2>", "children", "undergoing", "general", "anaesthesia", "strabismus", "repair", "tonsillectomy", "with", "or", "without", "adenoidectomy", "."], "h": {"id": "C0061863", "name": "C0061863#ent", "pos": [6, 7]}, "relation": "may_prevent", "t": {"id": "C0520909", "name": "C0520909#ent", "pos": [17, 18]}}
{"token": ["In", "conclusion", ",", "RTI", "was", "associated", "with", "transient", "increase", "in", "C0085129#ent", "<e1>", "athletes", "performing", "physical", "training", "the", "symptomatic", "period", "of", "C0221423#ent", "<e2>", "not", "in", "nonactive", "control", "subjects"], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [20, 21]}}
{"token": ["Captopril", "also", "lowered", "C1366837#ent", "<e1>", "by", "40", "%", "and", "CGS", "13945", "lowered", "C3710929#ent", "<e2>", "expression", "to", "30", "%", "of", "the", "control", "level"], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3710929", "name": "C3710929#ent", "pos": [12, 13]}}
{"token": ["C0016395#ent", "<e1>", "a", "rare", "C1848862#ent", "<e2>", "with", "widespread", "dysplasia", "of", "mesodermal", "and", "ectodermal", "tissues"], "h": {"id": "C0016395", "name": "C0016395#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}}
{"token": ["C0016395#ent", "<e1>", "FDH", ")", "is", "a", "rare", "C1848862#ent", "<e2>", "of", "severe", "developmental", "anomalies", "the", "tissues", "and", "organs", "derived", "from", "ectoderm", "and", "mesoderm", "."], "h": {"id": "C0016395", "name": "C0016395#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [7, 8]}}
{"token": ["A", "polarity", "suppressor", "mutation", "the", "C1419385#ent", "<e1>", "no", "effect", "on", "the", "defect", "in", "C1421976#ent", "<e2>", "in", "the", "divE", "mutant", "."], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "loss", "of", "Six1", "function", "C2712370#ent", "<e1>", "the", "expression", "pattern", "of", "C1415624#ent", "<e2>", "and", "Gata3", ",", "indicating", "that", "Six1", "is", "required", "for", "regional", "specification", "of", "the", "otic", "vesicle"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415624", "name": "C1415624#ent", "pos": [12, 13]}}
{"token": ["C0220918#ent", "<e1>", ":", "quinone", "oxidoreductase", "SQR", ")", "from", "Bacillus", "subtilis", "of", "two", "C0599220#ent", "<e2>", "succinate", "dehydrogenase", "and", "a", "di-heme", "membrane", "anchor", "protein", "harboring", "two", "putative", "quinone", "binding", "sites", "Q(p", ")", "and", "Q(d", ")", "."], "h": {"id": "C0220918", "name": "C0220918#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}}
{"token": ["A", "C0220918#ent", "<e1>", "dehydrogenase-negative", "mutant", "of", "Bacillus", "subtilis", "described", "which", "lacks", "all", "three", "C0599220#ent", "<e2>", "of", "the", "membrane-bound", "succinate", "dehydrogenase", "complex", "flavoprotein", ",", "iron", "protein", "and", "cytochrome", "b558"], "h": {"id": "C0220918", "name": "C0220918#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [13, 14]}}
{"token": ["C1528018#ent", "<e1>", "has", "been", "reported", "to", "be", "a", "C0079427#ent", "<e2>", "but", "details", "of", "its", "expression", "in", "human", "cancer", "controversial", "."], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [8, 9]}}
{"token": ["A", "novel", "tetrapeptide", "derivative", "Boc-Lys(Boc)-Arg-Asp-Ser(tbu)-OtBu", "(", "PEP1261", ")", "has", "been", "tested", "in", "vivo", "C0282210#ent", "<e1>", "(", "ISO", ")", "hydrochloride", "(HCl)-induced", "C1442837#ent", "<e2>", "rats", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1442837", "name": "C1442837#ent", "pos": [20, 21]}}
{"token": ["These", "studies", "disclosed", "the", "unique", "nature", "of", "C0282210#ent", "<e1>", "in", "producing", "'", "infarct-like", "'", "C1442837#ent", "<e2>"], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1442837", "name": "C1442837#ent", "pos": [14, 15]}}
{"token": ["C0282210#ent", "<e1>", "at", "0.5", "micrograms/kg", "produced", "only", "very", "minimal", "or", "no", "C1442837#ent", "<e2>", "did", "not", "produce", "resistance", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1442837", "name": "C1442837#ent", "pos": [11, 12]}}
{"token": ["Gene", "expression", "evaluated", "in", "the", "myocardium", "of", "male", "Wistar", "rats", "a", "single", "subcutaneous", "administration", "of", "0.5", "mg", "of", "C0282210#ent", "<e1>", ",", "a", "beta-adrenergic", "agonist", "causes", "acute", "tachycardia", "subsequent", "C1442837#ent", "<e2>"], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1442837", "name": "C1442837#ent", "pos": [28, 29]}}
{"token": ["Decreased", "activity", "of", "C0001044#ent", "<e1>", "may", "be", "an", "early", "step", "in", "development", "of", "the", "C0206157#ent", "<e2>", "that", "occurs", "after", "large", "dose", "2,4-D."], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0206157", "name": "C0206157#ent", "pos": [14, 15]}}
{"token": ["The", "filtered", "smoke", "was", "bubbled", "into", "a", "C0067942#ent", "<e1>", "solution", "of", "C0070616#ent", "<e2>", "and", "the", "resulting", "nitroxide", "radicals", "were", "detected", "by", "ESR", "."], "h": {"id": "C0067942", "name": "C0067942#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0070616", "name": "C0070616#ent", "pos": [11, 12]}}
{"token": ["Differences", "in", "glucocorticoid", "(", "C1367452#ent", "<e1>", ")", "sensitivity", "may", "underlie", "both", "common", "C0012634#ent", "<e2>", "(", "e.g.", "hypertension", ")", "and", "variability", "in", "response", "to", "treatment", "with", "GCs", "(", "e.g.", "asthma", ")", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}}
{"token": ["Glucocorticoids", "(", "C1367452#ent", "<e1>", ")", "are", "highly", "effective", "in", "the", "control", "of", "C0012634#ent", "<e2>", "associated", "with", "T", "cell", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}}
{"token": ["C", ")", "normal", "cholescintigraphy", "but", "C0856727#ent", "<e1>", "(", "false", "negative", ",", "(", "D", ")", "normal", "cholescintigraphy", "and", "C2609268#ent", "<e2>", "and", "(", "E", ")", "cholescintigraphy", "in", "icteric", "patients", "."], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C2609268", "name": "C2609268#ent", "pos": [17, 18]}}
{"token": ["Represented", "were", "patients", "with", "C0856727#ent", "<e1>", "as", "well", "as", "controls", "with", "pigment", "gallstones", "without", "C2609268#ent", "<e2>"], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C2609268", "name": "C2609268#ent", "pos": [14, 15]}}
{"token": ["The", "presence", "of", "a", "thickened", "gallbladder", "wall", "C0856727#ent", "<e1>", ",", "or", "a", "nonvisualized", "gallbladder", "indicates", "C2609268#ent", "<e2>"], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C2609268", "name": "C2609268#ent", "pos": [15, 16]}}
{"token": ["Analysis", "of", "sequences", "of", "various", "peptide", "O-xylosyltransferase", "C1415023#ent", "<e1>", "that", "they", "are", "members", "of", "a", "large", "C1415740#ent", "<e2>", "a", "range", "of", "roles", "in", "beta-glycosylation", "of", "either", "peptide", "or", "glycan", "substrates", "."], "h": {"id": "C1415023", "name": "C1415023#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [16, 17]}}
{"token": ["The", "four", "subsite", "model", "for", "isomaltase", "and", "C0002272#ent", "<e1>", "is", "an", "indication", "that", "these", "two", "enzymes", "are", "mechanistically", "C1334043#ent", "<e2>", "in", "binding", "linear", "glucosyl-oligosaccharides", "."], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["Immuno-inhibition", "of", "intestinal", "aminopeptidase", "C0002272#ent", "<e1>", "and", "glucoamylase", "by", "C1334043#ent", "<e2>", "not", "observed", "."], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["It", "is", "suggested", "that", "C3540725#ent", "<e1>", "do", "pave", "the", "way", "for", "C0029118#ent", "<e2>", "in", "this", "case", "."], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029118", "name": "C0029118#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "C0268743#ent", "<e1>", "no", "longer", "be", "regarded", "as", "a", "subtype", "of", "C0017662#ent", "<e2>"], "h": {"id": "C0268743", "name": "C0268743#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0017662", "name": "C0017662#ent", "pos": [12, 13]}}
{"token": ["C0268743#ent", "<e1>", "the", "kidney", "is", "a", "rare", "form", "of", "C0017662#ent", "<e2>", "associated", "with", "serum", "complement", "abnormalities", "low", "C3", "levels", ")", "and", "a", "circulating", "C3", "convertase", "activator", "the", "alternative", "pathway", "the", "C3", "nephritic", "factor", "NF", ")", "."], "h": {"id": "C0268743", "name": "C0268743#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0017662", "name": "C0017662#ent", "pos": [9, 10]}}
{"token": ["A", "review", "of", "the", "histologic", "findings", "in", "27", "patients", "originally", "classified", "as", "having", "some", "form", "of", "membranoproliferative", "glomerulonephritis", "C0268743#ent", "<e1>", ")", "revealed", "13", "with", "C0017662#ent", "<e2>", "14", "with", "dense", "deposit", "disease", "DDD", ")", "."], "h": {"id": "C0268743", "name": "C0268743#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0017662", "name": "C0017662#ent", "pos": [24, 25]}}
{"token": ["The", "radical", "scavengers", "N-acetyl-L-cysteine", "(NAC)(20", "mM", ")", "and", "C0011176#ent", "<e1>", "(", "5", "mM", ")", "inhibited", "both", "C0289313#ent", "<e2>", "production", "and", "the", "[Ca2+]i", "transient", "during", "electrical", "field", "."], "h": {"id": "C0011176", "name": "C0011176#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [16, 17]}}
{"token": ["Disordered", "activation", "of", "C2830173#ent", "<e1>", "LO", "and", "COX", "enzymes", "have", "been", "implicated", "in", "many", "C0033581#ent", "<e2>"], "h": {"id": "C2830173", "name": "C2830173#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [14, 15]}}
{"token": ["Extracellular", "C2830173#ent", "<e1>", "fluids", "of", "patients", "with", "C0033581#ent", "<e2>", "as", "sepsis", ",", "acute", "pancreatitis", "rheumatoid", "arthritis", "also", "associated", "with", "propagation", "of", "inflammation", "."], "h": {"id": "C2830173", "name": "C2830173#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [7, 8]}}
{"token": ["The", "interaction", "requires", "the", "N-terminal", "part", "Evi1", "and", "the", "H3-specific", "histone", "methyltransferase", "domain", "SET", ",", "of", "C1420532#ent", "<e1>", "without", "Evi1", "having", "an", "inhibitory", "effect", "on", "C0914122#ent", "<e2>", "activity", "."], "h": {"id": "C1420532", "name": "C1420532#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0914122", "name": "C0914122#ent", "pos": [25, 26]}}
{"token": ["Finally", ",", "the", "human", "C1420532#ent", "<e1>", "able", "to", "partially", "rescue", "C0914122#ent", "<e2>", "-", "9", "silencing", "defects", "."], "h": {"id": "C1420532", "name": "C1420532#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0914122", "name": "C0914122#ent", "pos": [10, 11]}}
{"token": ["Diazepam", ",", "unlike", "midazolam", "and", "triazolam", ",", "can", "be", "prescribed", "in", "usual", "doses", "patients", "receiving", "itraconazole", "and", "probably", "other", "inhibitors", "of", "C1142644#ent", "<e1>", ",", "at", "least", "when", "C0012010#ent", "<e2>", "is", "used", "as", "single", "doses"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [21, 22]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [27, 28]}}
{"token": ["The", "interactions", "of", "fipronil", "and", "other", "C1142644#ent", "<e1>", "substrates", ",", "such", "as", "testosterone", "and", "C0012010#ent", "<e2>", ",", "were", "also", "investigated", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [14, 15]}}
{"token": ["Protein-tyrosine", "phosphatases", "C0284927#ent", "<e1>", ")", "constitute", "a", "family", "of", "C1414463#ent", "<e2>", ",", "and", "cytoplasmic", "enzymes", "which", "catalyze", "the", "dephosphorylation", "of", "phosphotyrosine", "residues", "a", "variety", "of", "receptors", "and", "signaling", "molecules"], "h": {"id": "C0284927", "name": "C0284927#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414463", "name": "C1414463#ent", "pos": [9, 10]}}
{"token": ["A", "43-year-old", "man", "with", "Eaton-Lambert", "syndrome", "C0238304#ent", "<e1>", "4", "years", "of", "C0120447#ent", "<e2>"], "h": {"id": "C0238304", "name": "C0238304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0120447", "name": "C0120447#ent", "pos": [11, 12]}}
{"token": ["The", "specific", "diagnosis", "of", "these", "C0012634#ent", "<e1>", "requires", "histopathologic", "study", "different", "C0030327#ent", "<e2>", "usually", "show", "the", "same", "clinical", "appearance", "which", "consists", "of", "erythematous", "nodules", "the", "lower", "extremities"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030327", "name": "C0030327#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "activation", "of", "mitochondrial", "apoptosis", "to", "altered", "Bcl-x", "splicing", "contributes", "as", "a", "common", "mechanism", "of", "anthracyclines", "and", "C1706111#ent", "<e1>", "signal", "attenuation", "to", "the", "enhanced", "C0018801#ent", "<e2>", "risk", "under", "this", "combination", "."], "h": {"id": "C1706111", "name": "C1706111#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [26, 27]}}
{"token": ["Ser-696", "and", "Ser-787", ",", "both", "of", "which", "lie", "within", "SPXK", "consensus", "sequences", "C0080054#ent", "<e1>", "were", "identified", "as", "phosphorylation", "sites", "in", "the", "proline-rich", "region", "C1417017#ent", "<e2>", "in", "vivo", "in", "vitro"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417017", "name": "C1417017#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "that", "C0080054#ent", "<e1>", "regulates", "microtubule", "dynamics", "at", "mitosis", "through", "phosphorylation", "of", "C1417017#ent", "<e2>", "at", "a", "number", "of", "sites", ",", "including", "Ser-787", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417017", "name": "C1417017#ent", "pos": [14, 15]}}
{"token": ["It", "could", "be", "considered", "as", "a", "useful", "C0013227#ent", "<e1>", "in", "the", "prophylaxis", "of", "cardiac", "surgery", "in", "therapy", "of", "C0014121#ent", "<e2>", "to", "susceptible", "micro-organisms", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [18, 19]}}
{"token": ["Penicillin", "is", "the", "C0013227#ent", "<e1>", "of", "choice", "for", "the", "prevention", "of", "C0014121#ent", "<e2>", "BE", ")", "resulting", "from", "dental", "treatment"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "satisfactory", "diffusion", "of", "ofloxacin", "into", "heart", "tissue", "to", "favor", "use", "of", "the", "C0013227#ent", "<e1>", "in", "the", "treatment", "of", "C0014121#ent", "<e2>", "to", "susceptible", "pathogens", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [21, 22]}}
{"token": ["It", "is", "known", "that", "plasma", "C0282526#ent", "<e1>", "levels", "are", "elevated", "in", "patients", "with", "C0043459#ent", "<e2>", "a", "genetic", "disorder", "and", "chronic", "liver", "diseases"], "h": {"id": "C0282526", "name": "C0282526#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [13, 14]}}
{"token": ["Increased", "levels", "of", "C0282526#ent", "<e1>", "been", "reported", "in", "patients", "with", "C0043459#ent", "<e2>", "CHRS", ")", "of", "Zellweger", "and", "the", "general", "deficiency", "peroxisomal", "function", "been", "implicated", "in", "its", "pathogenesis", "."], "h": {"id": "C0282526", "name": "C0282526#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [10, 11]}}
{"token": ["The", "metabolism", "of", "C0282526#ent", "<e1>", "been", "studied", "in", "three", "patients", "suffering", "from", "the", "C0043459#ent", "<e2>", "Zellweger", "."], "h": {"id": "C0282526", "name": "C0282526#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [13, 14]}}
{"token": ["In", "a", "screen", "for", "mutants", "affected", "in", "morphogenesis", "and", "cytokinesis", ",", "we", "identified", "the", "C1413288#ent", "<e1>", "a", "member", "of", "the", "family", "of", "C1955933#ent", "<e2>", "PAKs", ")", "."], "h": {"id": "C1413288", "name": "C1413288#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1955933", "name": "C1955933#ent", "pos": [22, 23]}}
{"token": ["The", "data", "suggest", "that", "the", "C0003364#ent", "<e1>", "clonidine", "depends", "partially", "upon", "the", "integrity", "of", "C0242893#ent", "<e2>", "neurons", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [14, 15]}}
{"token": ["Using", "sodium", "hypochlorite", "98.5", "%", "of", "C0002699#ent", "<e1>", ",", "99.0", "%", "of", "Azathioprine", ",", "99.5", "%", "of", "C2681123#ent", "<e2>", "and", "98.7", "%", "of", "Thiotepa", "were", "destroyed", "after", "1", "hr", "."], "h": {"id": "C0002699", "name": "C0002699#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2681123", "name": "C2681123#ent", "pos": [17, 18]}}
{"token": ["Cathepsin", "B", "C1413814#ent", "<e1>", "B+L", "activities", "and", "the", "C2678065#ent", "<e2>", "elevated", "ionic", "strength", "not", "different", "between", "breeds", ",", "but", "both", "could", "be", "related", "to", "the", "postmortem", "increase", "in", "tenderness", "of", "both", "breeds", "."], "h": {"id": "C1413814", "name": "C1413814#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2678065", "name": "C2678065#ent", "pos": [8, 9]}}
{"token": ["ES", "significantly", "increased", "the", "activities", "of", "C1413814#ent", "<e1>", "B+L", "in", "the", "C2678065#ent", "<e2>", "but", "there", "were", "no", "differences", "in", "proteolytic", "activity", "the", "other", "fractions", "."], "h": {"id": "C1413814", "name": "C1413814#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2678065", "name": "C2678065#ent", "pos": [11, 12]}}
{"token": ["The", "C1416655#ent", "<e1>", "commonly", "mutated", ",", "causing", "C0907533#ent", "<e2>", "activation", "of", "the", "protein", "and", "aberrant", "growth", "."], "h": {"id": "C1416655", "name": "C1416655#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}}
{"token": ["In", "addition", "to", "these", "loss-of-function", "mutations", ",", "gain-of-function", "mutations", "in", "C1416655#ent", "<e1>", ",", "leading", "to", "C0907533#ent", "<e2>", "activation", "of", "the", "Kit", "receptor", "have", "also", "been", "identified", "in", "both", "rodent", "and", "human", "mastocytomas", "."], "h": {"id": "C1416655", "name": "C1416655#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [15, 16]}}
{"token": ["The", "usefulness", "of", "2", "diagnostic", "procedures", "fructose", "tolerance", "test", "C1997142#ent", "<e1>", ")", "and", "aldolase", "assay", "biopsied", "C0023899#ent", "<e2>", ",", "was", "studied", "."], "h": {"id": "C1997142", "name": "C1997142#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["A", "CT", "scan", "multiple", "calcifications", "throughout", "the", "C0771711#ent", "<e1>", ",", "with", "a", "C0029927#ent", "<e2>", "the", "tail", "of", "the", "C0771711#ent", "<e1>", "involving", "the", "spleen", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029927", "name": "C0029927#ent", "pos": [12, 13]}}
{"token": ["Necrotic", "adenocarcinoma", "the", "C0771711#ent", "<e1>", "may", "simulate", "a", "C0029927#ent", "<e2>", "the", "C0771711#ent", "<e1>", "on", "computed", "tomography", "ultrasound", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029927", "name": "C0029927#ent", "pos": [8, 9]}}
{"token": ["We", "have", "generated", "a", "hybrid", "transgenic", "mouse", "line", "overexpressing", "both", "C0029282#ent", "<e1>", "ODC", ")", "and", "spermidine/spermine", "N(1)-acetyltransferase", "C1822614#ent", "<e2>", ")", "under", "the", "control", "of", "the", "mouse", "metallothionein", "MT", ")", "I", "promoter", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1822614", "name": "C1822614#ent", "pos": [17, 18]}}
{"token": ["It", "was", "found", "that", "the", "repression", "of", "C0029282#ent", "<e1>", "activity", "by", "polyamines", "and", "the", "induction", "of", "C1822614#ent", "<e2>", "polyamine", "analogues", "including", "bis(ethyl)spermine", "derivatives", "required", "the", "presence", "of", "a", "functional", "polyamine", "transport", "system"], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1822614", "name": "C1822614#ent", "pos": [16, 17]}}
{"token": ["Additional", "anticoagulation", "options", "include", "unfractionated", "heparin", ",", "C0019139#ent", "<e1>", "e.g.", ",", "enoxaparin", ",", "dalteparin", ",", "and", "C0216278#ent", "<e2>", ")", ",", "and", "the", "indirect-acting", "factor", "Xa", "inhibitor", "fondaparinux", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [7, 8]}, "relation": "chemical_structure_of", "t": {"id": "C0216278", "name": "C0216278#ent", "pos": [16, 17]}}
{"token": ["Among", "the", "notifiable", "diseases", "with", "fatal", "outcome", "(", "section", "sign", ")", "belonged", "3", "cases", "of", "Meningococcus", "sepsis", "13", "of", "C0041323#ent", "<e1>", "und", "5", "cases", "of", "C0022336#ent", "<e2>"], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [25, 26]}}
{"token": ["Treatment", "of", "male", "Atlantic", "cod", "17", "C0014914#ent", "<e1>", "resulted", "in", "increased", "CYP1A", "and", "C1176140#ent", "<e2>", "."], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [13, 14]}}
{"token": ["Narrow-band", "ultraviolet", "B", "(", "NB-UVB", ")", "therapy", "has", "been", "used", "successfully", "for", "the", "treatment", "of", "inflammatory", "and", "C1704421#ent", "<e1>", "atopic", "dermatitis", "psoriasis", ",", "mycosis", "fungoides", "polymorphous", "light", "eruption", "and", "C0042900#ent", "<e2>", "."], "h": {"id": "C1704421", "name": "C1704421#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [29, 30]}}
{"token": ["The", "specific", "diagnoses", "discussed", "in", "the", "different", "racial", "groups", "acne", ";", "C1704421#ent", "<e1>", "as", "postinflammatory", "hyperpigmentation", "hypopigmentation", ",", "C0042900#ent", "<e2>", ",", "and", "melasma", ";", "and", "photoaging", "."], "h": {"id": "C1704421", "name": "C1704421#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [18, 19]}}
{"token": ["We", "have", "selected", "mouse", "myeloma", "leukemia", "cell", "lines", "ornithine", "decarboxylase", "C1422630#ent", "<e1>", ")", "under", "the", "pressure", "of", "C0282042#ent", "<e2>", "(", "DFMO", ")", ",", "a", "mechanism-based", "inhibitor", "of", "the", "enzyme", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282042", "name": "C0282042#ent", "pos": [17, 18]}}
{"token": ["Myc-induced", "apoptosis", "operates", "through", "C1422630#ent", "<e1>", "and", "can", "be", "prevented", "with", "the", "C1422630#ent", "<e1>", "inhibitor", ",", "C0282042#ent", "<e1>", "(", "DFMO", ")", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282042", "name": "C0282042#ent", "pos": [16, 17]}}
{"token": ["The", "expression", "of", "CD45RA", ",", "CD45RB", "and", "C3891563#ent", "<e1>", "on", "CD34", "+", "and", "CD34-", "C0018939#ent", "<e2>", "umbilical", "cord", "blood", "bone", "marrow", "fetal", "liver", "studied", "by", "flow", "cytometry"], "h": {"id": "C3891563", "name": "C3891563#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [14, 15]}}
{"token": ["In", "sucrose", "density", "centrifugation", "the", "NADH-", "and", "NADPH-cytochrome", "c", "reductase", "of", "the", "C1423498#ent", "<e1>", "identically", "with", "C0016964#ent", "<e2>", "but", "differently", "from", "the", "reductase", "activities", "microsomes", ",", "again", "indicating", "that", "the", "reductases", "are", "inherently", "associated", "with", "Golgi", "apparatus"], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [16, 17]}}
{"token": ["The", "C1423498#ent", "<e1>", "most", "of", "the", "C0016964#ent", "<e2>", "(", "beta-Gal", "transferase", ")", "and", "UDP-N-acetyl-glucosamine", ":", "polypeptide-alpha-N-acetyl-glucosaminyltransferase", "(", "O-alpha-GlcNAc", "transferase", "activities", "with", "minimal", "contamination", "of", "other", "organelles", ",", "as", "observed", "by", "enzymatic", "assays", "electron", "microscopy", "analysis"], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [6, 7]}}
{"token": ["On", "the", "other", "hand", ",", "C0684219#ent", "<e1>", "with", "hyperhidrosis", "is", "known", "as", "C0242287#ent", "<e2>"], "h": {"id": "C0684219", "name": "C0684219#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0242287", "name": "C0242287#ent", "pos": [12, 13]}}
{"token": ["Neuromyotonia", "is", "a", "disorder", "of", "peripheral", "nerve", "hyperexcitability", "characterized", "by", "C0684219#ent", "<e1>", ",", "muscle", "cramps", "stiffness", ",", "delayed", "muscle", "relaxation", "contraction", "(", "C0242287#ent", "<e2>", ")", ",", "and", "hyperhidrosis", ",", "associated", "with", "described", "spontaneous", "electromyographic", "features", "."], "h": {"id": "C0684219", "name": "C0684219#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0242287", "name": "C0242287#ent", "pos": [22, 23]}}
{"token": ["The", "results", "were", "consistent", "with", "gene", "expression", "microarray", "data", ":", "C1415328#ent", "<e1>", "highly", "expressed", "in", "clear", "cell", "RCC", "alpha", "methylacyl", "racemase", "papillary", "RCC", "carbonic", "anhydrase", "II", "chromophobe", "RCC", "C1705721#ent", "<e2>", "in", "TCC", "."], "h": {"id": "C1415328", "name": "C1415328#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705721", "name": "C1705721#ent", "pos": [28, 29]}}
{"token": ["Infusions", "of", "saline", "directly", "into", "the", "C1412302#ent", "<e1>", "did", "not", "impair", "the", "performance", "of", "C0010278#ent", "<e2>", "to", "either", "the", "tone", "or", "light", "CS"], "h": {"id": "C1412302", "name": "C1412302#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [14, 15]}}
{"token": ["The", "infusion", "of", "lidocaine", "into", "regions", "surrounding", "the", "C1412302#ent", "<e1>", "did", "not", "affect", "C0010278#ent", "<e2>", "elicited", "by", "the", "light", "CS", "prevent", "acquisition", "of", "C0010278#ent", "<e2>", "to", "the", "tone", "."], "h": {"id": "C1412302", "name": "C1412302#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [13, 14]}}
{"token": ["Especially", ",", "experimental", "studies", "the", "enhancement", "of", "antitumor", "effect", "the", "combination", "of", "C0013227#ent", "<e1>", "calcium", "or", "C0021643#ent", "<e2>", "also", "overcome", "of", "vincristine", "resistance", "the", "combination", "of", "vincristine", "with", "a", "calcium", "antagonist", "verapamil", ",", "were", "described", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0021643", "name": "C0021643#ent", "pos": [16, 17]}}
{"token": ["Synapsins", "are", "C1414404#ent", "<e1>", "phosphoproteins", "of", "small", "synaptic", "vesicles", "by", "two", "different", "C1417679#ent", "<e2>", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Neurotransmission", "at", "chemical", "synapses", "the", "brain", "involves", "alpha-neurexins", ",", "C1414404#ent", "<e1>", "cell-surface", "molecules", "that", "are", "encoded", "by", "three", "C1417679#ent", "<e2>", "in", "mammals", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["The", "other", "C0029896#ent", "<e1>", "include", "noncryoglobulinemic", "systemic", "vasculitis", "splenic", "lymphoma", "villous", "lymphocytes", "fatigue", ",", "C0162566#ent", "<e2>", "sicca", "syndrome", "and", "autoantibodies", "production", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [14, 15]}}
{"token": ["A", "37-year-old", "male", "with", "C0087090#ent", "<e1>", "TBG", ")", "deficiency", "associated", "with", "C0339143#ent", "<e2>", "described", "."], "h": {"id": "C0087090", "name": "C0087090#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [11, 12]}}
{"token": ["C0079286#ent", "<e1>", "was", "found", "to", "produce", "electrographically", "defined", "C0036572#ent", "<e2>", "unaccompanied", "by", "convulsive", "motor", "behavior", "cataleptic", "seizures", ",", "as", "well", "as", "convulsive", "seizures"], "h": {"id": "C0079286", "name": "C0079286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}}
{"token": ["Systemic", "or", "intracisternal", "injection", "of", "both", "morphine", "and", "C0079286#ent", "<e1>", "decreased", "the", "incidence", "of", "C0036572#ent", "<e2>", "and", "the", "seizure", "score", "El", "mice", "a", "dose-dependent", "manner", "."], "h": {"id": "C0079286", "name": "C0079286#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [14, 15]}}
{"token": ["Treponemicidal", "levels", "of", "penicillin", "in", "the", "CSF", "were", "not", "obtained", "following", "intramuscular", "(", "IM", ")", "injections", "of", "600,000", "IU", "of", "penicillin", "G", "C0033218#ent", "<e1>", "along", "with", "2", "%", "aluminum", "monostearate", "C2931826#ent", "<e2>", ")", "."], "h": {"id": "C0033218", "name": "C0033218#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2931826", "name": "C2931826#ent", "pos": [30, 31]}}
{"token": ["The", "TSHR", ",", "like", "insulin", ",", "may", "release", "a", "C0071642#ent", "<e1>", "intramolecular", "cleavage", "into", "two", "C0599220#ent", "<e2>", "."], "h": {"id": "C0071642", "name": "C0071642#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [15, 16]}}
{"token": ["We", "found", "that", "valproic", "acid", "VPA", ")", ",", "but", "not", "lamotrigine", "(", "LTG", ")", ",", "was", "capable", "of", "suppressing", "seizure-induced", "C0087140#ent", "<e1>", "and", "c-Jun", "mRNA", "expression", "in", "rats", "despite", "a", "similar", "C0003286#ent", "<e2>"], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [31, 32]}}
{"token": ["C0025517#ent", "<e1>", "8", "to", "43", "%", "of", "the", "reported", "C1706048#ent", "<e2>", "in", "category", "I", "colleges", "and", "0", "-", "46", "%", "in", "the", "other", "pediatric", "centres"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706048", "name": "C1706048#ent", "pos": [9, 10]}}
{"token": ["C1537932#ent", "<e1>", "encodes", "a", "approximately", "36-kDa", "transmembrane", "protein", "is", "highly", "homologous", "to", "C1537930#ent", "<e2>", "and", "-2", "."], "h": {"id": "C1537932", "name": "C1537932#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537930", "name": "C1537930#ent", "pos": [12, 13]}}
{"token": ["This", "study", "compared", "the", "catalytic", "properties", "of", "C1537932#ent", "<e1>", "with", "those", "of", "C1537930#ent", "<e2>", "and", "MGAT2", "enzymes", "using", "both", "MAG", "and", "DAG", "as", "substrates", "."], "h": {"id": "C1537932", "name": "C1537932#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1537930", "name": "C1537930#ent", "pos": [12, 13]}}
{"token": ["In", "the", "course", "of", "the", "disease", ",", "acral", "pseudosyndactyly", "developed", ",", "and", "the", "patient", "suffered", "from", "corneal", "erosions", "C0014866#ent", "<e1>", "malabsorption", ",", "recurrent", "severe", "pneumonias", "and", "C1704321#ent", "<e2>"], "h": {"id": "C0014866", "name": "C0014866#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [26, 27]}}
{"token": ["Plasma", "fibrinogen", "factor", "VII", "von", "Willebrand", "factor", "C1336938#ent", "<e1>", ")", "were", "unaffected", "by", "particle", "treatments", "was", "plasma", "Trolox", "equivalent", "C0003402#ent", "<e2>", "TEAC", ")", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [19, 20]}}
{"token": ["The", "wild-type", "and", "the", "C0298973#ent", "<e1>", "expressed", "in", "the", "fission", "yeast", "Schizosaccharomyces", "pombe", "the", "control", "of", "C1823482#ent", "<e2>", "promoter", "."], "h": {"id": "C0298973", "name": "C0298973#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1823482", "name": "C1823482#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "with", "a", "variant", "of", "C0013720#ent", "<e1>", "about", "half", "of", "the", "secreted", "C0057252#ent", "<e2>", "lacks", "the", "single", "glycosaminoglycan", "side", "chain"], "h": {"id": "C0013720", "name": "C0013720#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0057252", "name": "C0057252#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "several", "C0020923#ent", "<e1>", "containing", "drugs", "including", "keto", "on", "human", "C0599930#ent", "<e2>", "17,20-lyase", ",", "21-hydroxylase", ",", "11", "beta-hydroxylase", "and", "3", "beta-hydroxysteroid", "dehydrogenase-isomerase", "3", "beta-HSD-I", ")", "activities", "was", "studied", "in", "vitro"], "h": {"id": "C0020923", "name": "C0020923#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599930", "name": "C0599930#ent", "pos": [12, 13]}}
{"token": ["In", "the", "present", "study", ",", "we", "tested", "whether", "TMAO", "can", "be", "a", "better", "solute", "than", "C0017868#ent", "<e1>", "for", "two", "commonly", "used", "proteases", ",", "C0960371#ent", "<e2>", "and", "chymotrypsin", "."], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [23, 24]}}
{"token": ["Mutation", "of", "a", "single", "phosphorylation", "site", "on", "C1424597#ent", "<e1>", "relieves", "the", "inhibition", "and", "rescues", "chromatid", "separation", "extracts", "with", "high", "C3811768#ent", "<e2>", "activity", "."], "h": {"id": "C1424597", "name": "C1424597#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811768", "name": "C3811768#ent", "pos": [19, 20]}}
{"token": ["For", "continued", "relief", "of", "C0409959#ent", "<e1>", "this", "study", "supports", "repeat", "use", "of", "C0939234#ent", "<e2>", "patients", "who", "had", "a", "previous", "successful", "course", "of", "therapy", "."], "h": {"id": "C0409959", "name": "C0409959#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0939234", "name": "C0939234#ent", "pos": [12, 13]}}
{"token": ["Coagulation", "factors", "II", "V", ",", "VII", ",", "VIII", ",", "C1413052#ent", "<e1>", "and", "X", "are", "produced", "by", "C0669372#ent", "<e2>", "."], "h": {"id": "C1413052", "name": "C1413052#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}}
{"token": ["All", "these", "7", "animals", "had", "serum", "antibodies", "C1413052#ent", "<e1>", "isolated", "rabbit", "C0669372#ent", "<e2>", "and", "in", "vivo", "fixed", "IgG", "on", "their", "hepatocellular", "plasma", "membranes"], "h": {"id": "C1413052", "name": "C1413052#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [11, 12]}}
{"token": ["All", "C0054521#ent", "<e1>", "detected", "in", "P.", "brasiliensis", "transcriptome", ",", "with", "C1414270#ent", "<e2>", "as", "one", "of", "the", "most", "expressed", "genes", "."], "h": {"id": "C0054521", "name": "C0054521#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414270", "name": "C1414270#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "serum", "levels", "of", "C0011777#ent", "<e1>", "at", "several", "intervals", "after", "administration", "of", "Decadron", "(", "C2930043#ent", "<e2>", "phonophoresis", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [5, 6]}, "relation": "part_of", "t": {"id": "C2930043", "name": "C2930043#ent", "pos": [15, 16]}}
{"token": ["The", "stability", "of", "C0011777#ent", "<e1>", "suspensions", "and", "C2930043#ent", "<e2>", "injections", "that", "had", "been", "stored", "in", "hospital", "pharmacies", "the", "United", "States", "studied", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [3, 4]}, "relation": "part_of", "t": {"id": "C2930043", "name": "C2930043#ent", "pos": [7, 8]}}
{"token": ["injection", "of", "NSD", "(", "C0095548#ent", "<e1>", ",", "inhibitor", "of", "C0003806#ent", "<e2>", "100", "mg/kg", ")", "."], "h": {"id": "C0095548", "name": "C0095548#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003806", "name": "C0003806#ent", "pos": [9, 10]}}
{"token": ["Proper", "ovarian", "development", "requires", "the", "cell", "type-specific", "transcription", "factor", "C1420572#ent", "<e1>", ",", "a", "subunit", "of", "the", "core", "promoter", "recognition", "complex", "C1337106#ent", "<e2>", "."], "h": {"id": "C1420572", "name": "C1420572#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1337106", "name": "C1337106#ent", "pos": [20, 21]}}
{"token": ["These", "properties", "suggest", "that", "C1420572#ent", "<e1>", "is", "a", "cell", "type-specific", "subunit", "of", "C1337106#ent", "<e2>", "that", "may", "be", "responsible", "for", "mediating", "transcription", "by", "a", "subset", "of", "activators", "in", "B", "cells"], "h": {"id": "C1420572", "name": "C1420572#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1337106", "name": "C1337106#ent", "pos": [12, 13]}}
{"token": ["Multicellular", "spheroids", "from", "the", "colorectal", "cell", "lines", "HRT18", "and", "HT29", "were", "incubated", "for", "24", "h", "with", "1", "microgram", "ml-1", "C1415696#ent", "<e1>", "and", "0", ",", "1", ",", "2", "and", "4", "microM", "C0042523#ent", "<e2>", "."], "h": {"id": "C1415696", "name": "C1415696#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [30, 31]}}
{"token": ["Treatment", "with", "beta-blocking", "agents", "as", "C0033497#ent", "<e1>", "as", "an", "adjunct", "to", "C0039052#ent", "<e2>", "seems", "to", "be", "a", "promising", "approach", "which", "might", "deserve", "further", "consideration", "in", "similar", "cases", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [11, 12]}}
{"token": ["It", "has", "less", "pronounced", "membrane", "stabilising", "properties", "than", "C0033497#ent", "<e1>", "and", "has", "no", "demonstrable", "C0039052#ent", "<e2>", "normal", "anaesthetised", "cats", "or", "dogs", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [14, 15]}}
{"token": ["Serial", "iodination", "studies", "of", "four", "C0011608#ent", "<e1>", "patients", ",", "evaluated", "while", "taking", "C1639494#ent", "<e2>", "or", "sulfapyridine", ",", "showed", "inhibition", "of", "iodination", "by", "either", "drug", "."], "h": {"id": "C0011608", "name": "C0011608#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "recombinant", "Semliki", "Forest", "viruses", "SFV", ")", "expressing", "C0086376#ent", "<e1>", "corresponding", "to", "the", "C1540181#ent", "<e2>", "constructs", "were", "established", "and", "administered", "as", "live", "vaccines", "combination", "with", "particulate", "antigens"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1540181", "name": "C1540181#ent", "pos": [15, 16]}}
{"token": ["Indeed", ",", "treatment", "of", "macrophages", "with", "C1538714#ent", "<e1>", "increased", "SREBP-1", "processing", ",", "and", "mature", "C2986464#ent", "<e2>", "content", "(", "by", "5.7-fold", ")", "in", "the", "nucleus", "."], "h": {"id": "C1538714", "name": "C1538714#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [14, 15]}}
{"token": ["It", "has", "been", "found", "that", "8", "out", "of", "10", "C0002763#ent", "<e1>", "also", "induce", "arachidonic", "acid", "20:4", ")", "liberation", "and", "C0040060#ent", "<e2>"], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040060", "name": "C0040060#ent", "pos": [19, 20]}}
{"token": ["We", "successfully", "treated", "a", "33-year-old", "woman", "with", "C0015133#ent", "<e1>", "who", "developed", "systemic", "sclerosis", "refractory", "hemophagocytic", "syndrome", "C0242994#ent", "<e2>", ")", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242994", "name": "C0242994#ent", "pos": [16, 17]}}
{"token": ["Treatment", "with", "C0015133#ent", "<e1>", "for", "fulminant", "C0242994#ent", "<e2>", "was", "effective", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242994", "name": "C0242994#ent", "pos": [6, 7]}}
{"token": ["Of", "the", "six", "SAP", "C1417679#ent", "<e1>", "that", "were", "analyzed", "(", "C3273433#ent", "<e2>", "to", "SAP6", ")", ",", "only", "SAP4", "and", "SAP5", "were", "detectably", "induced", "during", "infection", "in", "this", "model", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273433", "name": "C3273433#ent", "pos": [10, 11]}}
{"token": ["C0010763#ent", "<e1>", "was", "induced", "2-fold", "by", "ethanol", "treatment", ",", "but", "C1620185#ent", "<e2>", "and", "CYP4A2", "were", "not", "reflecting", "the", "MAOS", "activity", "increased", "by", "ethanol", "treatment", "."], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [10, 11]}}
{"token": ["UVB", "was", "more", "effective", "in", "inducing", "C1705323#ent", "<e1>", "and", "DP", "in", "differentiated", "cells", "C1419061#ent", "<e2>", "and", "IP", "in", "undifferentiated", "cells"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419061", "name": "C1419061#ent", "pos": [13, 14]}}
{"token": ["Two-", "to", "3-fold", "higher", "activities", "or", "potencies", "with", "2-series", "versus", "3-series", "compounds", "were", "observed", "with", "C1705323#ent", "<e1>", ",", "PGD", "synthases", "microsomal", "PGE", "synthase-1", "and", "C1419061#ent", "<e2>", ",", "EP2", ",", "EP3", ",", "and", "FP", "receptors"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419061", "name": "C1419061#ent", "pos": [24, 25]}}
{"token": ["Instillation", "of", "glucocorticoids", "such", "as", "C0011777#ent", "<e1>", "is", "known", "to", "result", "in", "C0028840#ent", "<e2>"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028840", "name": "C0028840#ent", "pos": [12, 13]}}
{"token": ["This", "steroid", "provides", "anti-inflammatory", "efficacy", "to", "C0011777#ent", "<e1>", "with", "a", "reduced", "risk", "of", "inducing", "C0028840#ent", "<e2>"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028840", "name": "C0028840#ent", "pos": [14, 15]}}
{"token": ["with", "the", "cholestatic", "dyes", "bromcresol", "green", "BCG", ",", "30", "micromol/kg", ")", "and", "rose", "bengal", "(", "C1705628#ent", "<e1>", ",", "60", "micromol/kg", ")", "immediately", "prior", "C0000970#ent", "<e2>", "administration", "(", "500", "mg/kg", ",", "i.p", ".", ")", "."], "h": {"id": "C1705628", "name": "C1705628#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [23, 24]}}
{"token": ["C0608437#ent", "<e1>", "catalyzes", "the", "demethylation", "of", "the", "biphasic", "kinetics", "substrate", "C0027396#ent", "<e2>", ",", "and", "the", "CYP2C9*2", "R144C", ")", "and", "CYP2C9*3", "I359L", ")", "variants", "are", "associated", "with", "rates", "of", "(S)-naproxen", "demethylation"], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [10, 11]}}
{"token": ["2", "The", "locomotor", "suppressant", "effect", "of", "m-CPP", "was", "inhibited", "by", "the", "C0036753#ent", "<e1>", "metergoline", ",", "but", "not", "by", "C0031448#ent", "<e2>", ",", "propranolol", ",", "clonidine", ",", "or", "haloperidol", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [18, 19]}}
{"token": ["Fluorescence", "microscopy", "revealed", "that", "LDL", "and", "Tf", "are", "internalized", "by", "C1419718#ent", "<e1>", "transfected", "with", "LDLR", "or", "C1420708#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1419718", "name": "C1419718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [16, 17]}}
{"token": ["These", "may", "include", "modulation", "of", "G-protein", "activation", "regulators", "of", "G-protein", "signaling", "RGS", ")", "and", "modification", "of", "C0031672#ent", "<e1>", "Phosphorylation", "of", "phospholipase", "Cbeta3", "both", "C0033640#ent", "<e2>", "protein", "kinase", "C", "been", "demonstrated", "."], "h": {"id": "C0031672", "name": "C0031672#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [23, 24]}}
{"token": ["C0031007#ent", "<e1>", "was", "administered", "to", "56", "patients", "with", "advanced", "C1868675#ent", "<e2>", "were", "no", "longer", "satisfactorily", "responding", "to", "levodopa", "."], "h": {"id": "C0031007", "name": "C0031007#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1868675", "name": "C1868675#ent", "pos": [9, 10]}}
{"token": ["A", "potential", "role", "for", "the", "CD1", "family", "lipid", "Ag-presenting", "molecules", "in", "C1136254#ent", "<e1>", "in", "vivo", "investigated", "in", "human", "C0023343#ent", "<e2>", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [18, 19]}}
{"token": ["One", "possible", "mechanism", "of", "such", "C1412361#ent", "<e1>", "up-regulation", "implies", "the", "contribution", "of", "C3536868#ent", "<e2>", "hormonal", "changes", ":", "relative", "melatonin", "deficiency", "hyperglucocorticoidemia", "."], "h": {"id": "C1412361", "name": "C1412361#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536868", "name": "C3536868#ent", "pos": [12, 13]}}
{"token": ["An", "inoculum", "effect", "was", "observed", "with", "both", "C0597979#ent", "<e1>", "(", "TEM-1", ",", "C1706327#ent", "<e2>", ")", "positive", "and", "C0597979#ent", "<e1>", "negative", "strains", "of", "H.", "influenzae", "MICs", "were", "determined", "based", "on", "turbidity", "."], "h": {"id": "C1706327", "name": "C1706327#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0597979", "name": "C0597979#ent", "pos": [7, 8]}}
{"token": ["Given", "the", "accelerated", "aminoglycoside", "clearance", "reported", "in", "aphakic", "eyes", ",", "these", "findings", "imply", "that", "the", "mechanism", "of", "C0002556#ent", "<e1>", "be", "related", "to", "peak", "drug", "concentration", "than", "C0720099#ent", "<e2>", "of", "tissue", "exposure"], "h": {"id": "C0002556", "name": "C0002556#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [26, 27]}}
{"token": ["C0020352#ent", "<e1>", "was", "an", "effective", "C0032121#ent", "<e2>", "resulting", "in", "increases", "of", "preload", ",", "cardiac", "output", "oxygen", "delivery", "and", "oxygen", "consumption", "the", "hemodynamic", "effects", "of", "pentastarch", "infusion", "were", "equal", "or", "superior", "to", "those", "of", "albumin", "."], "h": {"id": "C0020352", "name": "C0020352#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032121", "name": "C0032121#ent", "pos": [5, 6]}}
{"token": ["Infusions", "of", "C0020352#ent", "<e1>", "(", "HES", ")", "solutions", "as", "C0032121#ent", "<e2>", "flow", "improvers", "play", "an", "increasing", "role", "in", "the", "treatment", "of", "various", "diseases", "."], "h": {"id": "C0020352", "name": "C0020352#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032121", "name": "C0032121#ent", "pos": [9, 10]}}
{"token": ["Improved", "C0003195#ent", "<e1>", "such", "as", "C0766326#ent", "<e2>", ";", "new", "classes", "of", "antiarrhythmic", "agents", "such", "as", "atrial", "repolarization", "agents", ";", "and", "upstream", "therapies", "dealing", "with", "substrate", "represent", "potential", "sources", "of", "new", "pharmacological", "therapies", "AF", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0766326", "name": "C0766326#ent", "pos": [5, 6]}}
{"token": ["Results", "with", "AAV", "2/2", ",", "2/1", ",", "and", "2/5", "vector", "pseudotypes", ",", "human", "or", "canine", "C1419622#ent", "<e1>", "cDNA", ",", "and", "C0669365#ent", "<e2>", "or", "tissue-specific", "promoters", "were", "similar", "."], "h": {"id": "C1419622", "name": "C1419622#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [20, 21]}}
{"token": ["Chronic", "treatment", "the", "antihypertensive", "drug", "hydralazine", "not", "affect", "the", "C1321567#ent", "<e1>", "state", "of", "streptozotocin", "(STZ)-diabetic", "rats", "but", "did", "prevent", "the", "C0020473#ent", "<e2>", "is", "synonymous", "with", "these", "diabetic", "animals", "."], "h": {"id": "C1321567", "name": "C1321567#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [20, 21]}}
{"token": ["These", "results", "support", "the", "hypothesis", "that", "NO", "inhibits", "C1705556#ent", "<e1>", "release", "from", "erythrocytes", "via", "inactivation", "of", "the", "C0752348#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [17, 18]}}
{"token": ["Accurate", "prediction", "of", "survival", "for", "patients", "with", "C2316810#ent", "<e1>", "ESRD", ")", "and", "C3266262#ent", "<e2>", "difficult", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3266262", "name": "C3266262#ent", "pos": [12, 13]}}
{"token": ["Overexpression", "of", "NREBP", "can", "also", "repress", "the", "transcription", "of", "C0019163#ent", "<e1>", "genes", "and", "the", "production", "of", "C0019163#ent", "<e1>", "virions", "in", "a", "transient", "transfection", "system", "mimics", "the", "C0042769#ent", "<e1>", "in", "vivo"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [26, 27]}}
{"token": ["It", "is", "noteworthy", "that", "serum", "C1412791#ent", "<e1>", "normalized", "in", "1/10", "patients", "during", "dihydroergocriptine", ",", "3/8", "during", "C0006230#ent", "<e2>", "and", "10/11", "during", "cabergoline", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [16, 17]}}
{"token": ["However", ",", "strong", "induction", "of", "NGAL", "in", "the", "epidermis", "was", "seen", "in", "a", "variety", "of", "C0037274#ent", "<e1>", "characterized", "by", "dysregulated", "epithelial", "differentiation", "such", "as", "psoriasis", ",", "C0011606#ent", "<e2>", "squamous", "cell", "carcinoma"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0011606", "name": "C0011606#ent", "pos": [26, 27]}}
{"token": ["We", "identified", "a", "new", "essential", "C0079429#ent", "<e1>", "of", "Saccharomyces", "cerevisiae", "designated", "C1417728#ent", "<e2>", "(", "nuclear", "integrity", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417728", "name": "C1417728#ent", "pos": [11, 12]}}
{"token": ["Some", "patients", "with", "C0005398#ent", "<e1>", "high", "levels", "of", "C0002484#ent", "<e2>", "parenchymatous", "liver", "disease"], "h": {"id": "C0005398", "name": "C0005398#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002484", "name": "C0002484#ent", "pos": [8, 9]}}
{"token": ["MAP", "kinases", "phosphatases", "MKPs", ")", "belong", "to", "the", "dual-specificity", "phosphatase", "family", "C3814443#ent", "<e1>", ")", "and", "dephosphorylate", "phosphothreonine", "and", "phosphotyrosine", "within", "C0169101#ent", "<e2>"], "h": {"id": "C3814443", "name": "C3814443#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [20, 21]}}
{"token": ["The", "correlation", "between", "the", "plasma", "brain", "natriuretic", "peptide", "left", "ventricular", "ejection", "fraction", "shifted", "downward", "in", "the", "patients", "with", "C0162674#ent", "<e1>", "compared", "with", "those", "with", "C2931157#ent", "<e2>"], "h": {"id": "C0162674", "name": "C0162674#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2931157", "name": "C2931157#ent", "pos": [24, 25]}}
{"token": ["However", ",", "data", "also", "suggest", "that", "signaling", "crosstalk", "between", "the", "C0051427#ent", "<e1>", "and", "C1332391#ent", "<e2>", "indicating", "an", "important", "role", "for", "the", "C0051427#ent", "<e1>", "in", "apoptosis", "."], "h": {"id": "C1332391", "name": "C1332391#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0051427", "name": "C0051427#ent", "pos": [10, 11]}}
{"token": ["The", "mitogenic", "effect", "these", "C0243192#ent", "<e1>", "was", "abolished", "in", "confluent", "C1704885#ent", "<e2>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704885", "name": "C1704885#ent", "pos": [10, 11]}}
{"token": ["These", "data", "led", "us", "to", "conclude", "that", "each", "of", "three", "EXT", "C1417679#ent", "<e1>", "studied", "contribute", "to", "Hh", ",", "C1414174#ent", "<e2>", "and", "Wg", "morphogen", "signaling", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414174", "name": "C1414174#ent", "pos": [18, 19]}}
{"token": ["OxPAPC", "up-regulated", "C1415619#ent", "<e1>", "mRNA", "and", "protein", "in", "a", "time-", "and", "concentration-dependent", "manner", ",", "whereas", "C0003209#ent", "<e2>", "TNF-alpha", "and", "lipopolysaccharide", "did", "not", "significantly", "induce", "C1415619#ent", "<e1>", "expression", "in", "human", "umbilical", "vein", "endothelial", "cells"], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [2, 3]}}
{"token": ["The", "metabolically", "active", "Hb-CD163-HO-1", "pathway", "resulted", "in", "synthesis", "of", "ferritin-1", "of", "the", "antioxidative", "and", "C0003209#ent", "<e1>", "to", "heme", "breakdown", "by", "C1415619#ent", "<e2>", "."], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [20, 21]}}
{"token": ["Inhibition", "of", "the", "C0014442#ent", "<e1>", "was", "reversed", "by", "C0724441#ent", "<e2>", "and", ",", "less", "potently", ",", "by", "phentolamine", "and", "prazosin", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [8, 9]}}
{"token": ["Autism", "is", "frequently", "associated", "with", "C0016667#ent", "<e1>", "tuberous", "sclerosis", "and", "may", "be", "caused", "by", "lead", "poisoning", "and", "C0025517#ent", "<e2>"], "h": {"id": "C0016667", "name": "C0016667#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [17, 18]}}
{"token": ["Plasma", "zinc", "levels", "were", "low", "in", "Crohn's", "disease", "particularly", "in", "C0162429#ent", "<e1>", "patients", ",", "and", "related", "to", "plasma", "C1412332#ent", "<e2>", "concentrations", ",", "but", "were", "normal", "in", "ulcerative", "colitis"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [18, 19]}}
{"token": ["In", "summary", ",", "G-CSF", ",", "IL-6", "and", "C1524095#ent", "<e1>", "levels", "were", "significantly", "elevated", "in", "C0243026#ent", "<e2>", "."], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [14, 15]}}
{"token": ["In", "addition", "to", "meningitis", ",", "11", "patients", "experienced", "subtle", "encephalitic", "signs", ",", "19", "had", "cranial", "neuritis", "most", "commonly", "unilateral", "or", "bilateral", "facial", "palsy", "and", "12", "developed", "C0027813#ent", "<e1>", "plexitis", ",", "or", "C0151295#ent", "<e2>"], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0151295", "name": "C0151295#ent", "pos": [31, 32]}}
{"token": ["C0027813#ent", "<e1>", "was", "present", "in", "13", ",", "C0151295#ent", "<e2>", "62", ",", "and", "distal", "symmetrical", "sensory", "or", "sensorimotor", "neuropathy", "19", "patients", "."], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0151295", "name": "C0151295#ent", "pos": [7, 8]}}
{"token": ["Clinical", "and", "electrophysiological", "findings", "suggest", "axonal", "lesions", "of", "the", "peripheral", "nerves", "occurring", "singly", "(", "C0027813#ent", "<e1>", ")", "or", "in", "various", "combinations", "(", "C0151295#ent", "<e2>", "."], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0151295", "name": "C0151295#ent", "pos": [22, 23]}}
{"token": ["Some", "patients", "may", "also", "be", "helped", "by", "treatment", "with", "beta-blocking", "drugs", "new", "C0991617#ent", "<e1>", "such", "as", "C0006462#ent", "<e2>", "which", "have", "no", "significant", "potential", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006462", "name": "C0006462#ent", "pos": [16, 17]}}
{"token": ["Less", "commonly", "prescribed", "C0991617#ent", "<e1>", "such", "as", "opiates", ",", "amantadine", ",", "C0006462#ent", "<e2>", ",", "piracetam", ",", "amitriptyline", ",", "and", "dopamine", "depleters", "can", "be", "tried", "in", "more", "treatment-refractory", "patients", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006462", "name": "C0006462#ent", "pos": [11, 12]}}
{"token": ["The", "C1452531#ent", "<e1>", "pp62c-Yes", ")", "encodes", "a", "non-receptor-type", "protein", "tyrosine", "kinase", "NRPTK", ")", "of", "the", "C0038085#ent", "<e2>"], "h": {"id": "C1452531", "name": "C1452531#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [15, 16]}}
{"token": ["C0175713#ent", "<e1>", "the", "association", "of", "three", "main", "features", ":", "C3887898#ent", "<e2>", "chorioretinopathia", "with", "lacunae", "and", "agenesis", "of", "the", "corpus", "callosum"], "h": {"id": "C0175713", "name": "C0175713#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C3887898", "name": "C3887898#ent", "pos": [9, 10]}}
{"token": ["In", "ten", "patients", ",", "C0013370#ent", "<e1>", "mistakenly", "diagnosed", "as", "ulcerative", "colitis", "C0156147#ent", "<e2>", "the", "colon", "because", "of", "the", "similarity", "of", "history", ",", "physical", "examination", "and", "routine", "laboratory", "studies", "well", "as", "findings", "on", "proctoscopic", "and", "barium", "enema", "examination"], "h": {"id": "C0013370", "name": "C0013370#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [11, 12]}}
{"token": ["One", "patient", "developed", "an", "amebic", "liver", "abscess", "also", "C0013370#ent", "<e1>", "which", "was", "mistaken", "for", "C0156147#ent", "<e2>"], "h": {"id": "C0013370", "name": "C0013370#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [14, 15]}}
{"token": ["Despite", "the", "above", ",", "diagnostic", "modalities", "IBD", "are", "as", "effective", "as", "those", "for", "C0013370#ent", "<e1>", ",", "particularly", "for", "C0156147#ent", "<e2>", "ileal", "involvement", "."], "h": {"id": "C0013370", "name": "C0013370#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [18, 19]}}
{"token": ["Surprisingly", ",", "C1260229#ent", "<e1>", "treatment", "triggered", "the", "degradation", "of", "the", "C1709825#ent", "<e2>", "a", "proteasome-dependent", "manner", "suggesting", "a", "novel", "mechanism", "of", "GSK-3", "regulation", "."], "h": {"id": "C1260229", "name": "C1260229#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1709825", "name": "C1709825#ent", "pos": [10, 11]}}
{"token": ["C2020284#ent", "<e1>", "an", "autosomal", "dominant", "condition", "characterised", "by", "degenerative", "eye", "C0022408#ent", "<e2>"], "h": {"id": "C2020284", "name": "C2020284#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [10, 11]}}
{"token": ["Since", "eight", "of", "the", "nine", "patients", "had", "C0020538#ent", "<e1>", "they", "may", "have", "responded", "maximally", "to", "the", "lower", "C0018312#ent", "<e2>", "doses", ",", "precluding", "larger", "decreases", "with", "the", "24", "and", "32", "mg", "doses", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0018312", "name": "C0018312#ent", "pos": [17, 18]}}
{"token": ["1", "patient", "each", "of", "the", "following", "conditions", "were", "also", "treated", ";", "prurigo", "nodularis", "C1419789#ent", "<e1>", ",", "solar", "keratosis", "ingrowing", "toe", "nail", "Bowen's", "disease", "infected", "callosity", "and", "C0002726#ent", "<e2>", "cure", "was", "achieved", "in", "the", "former", "4", "conditions", "."], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [26, 27]}}
{"token": ["The", "skeletal", "muscle", "C0007192#ent", "<e1>", "characterized", "by", "C0030552#ent", "<e2>", "difficulties", "in", "gait", "and", "locomotion", ",", "while", "chronic", "alcohol", "consumption", "leads", "to", "a", "decrease", "in", "cardiac", "contractility", "output", "."], "h": {"id": "C0007192", "name": "C0007192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "we", "confirm", "and", "extend", "previous", "findings", "of", "abnormal", "C1707081#ent", "<e1>", "in", "PSP", "and", "PD", ",", "and", "also", "demonstrate", "exaggerated", "C1707081#ent", "<e1>", "in", "extremity", "muscles", "of", "C0000294#ent", "<e1>", "patients", "."], "h": {"id": "C1707081", "name": "C1707081#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000294", "name": "C0000294#ent", "pos": [27, 28]}}
{"token": ["All", "patients", "had", "C1422035#ent", "<e1>", "disturbances", "such", "as", "decrease", "of", "C0155773#ent", "<e2>", "increase", "of", "venous", "drainage", "hepar", "and", "spleen", "."], "h": {"id": "C1422035", "name": "C1422035#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0155773", "name": "C0155773#ent", "pos": [10, 11]}}
{"token": ["The", "C1420613#ent", "<e1>", "is", "a", "strongly", "conserved", "protein", "domain", "174", "to", "186", "C3539946#ent", "<e2>", "length", ",", "that", "binds", "DNA", "."], "h": {"id": "C1420613", "name": "C1420613#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [12, 13]}}
{"token": ["As", "a", "consequence", "there", "have", "been", "significant", ",", "highly", "cost-effective", "and", "sustainable", "improvements", "in", "growth", "rates", "haemoglobin", "levels", "and", "decreases", "in", "the", "prevalence", "of", "ocular", "signs", "C1510471#ent", "<e1>", "in", "intestinal", "C0747256#ent", "<e2>"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [30, 31]}}
{"token": ["The", "interrelation", "of", "different", "grades", "of", "pulmonary", "congestion", "by", "chest", "roentgenogram", "the", "coronary", "care", "unit", "predischarge", "left", "ventricular", "(LV)", "ejection", "fraction", "C0059036#ent", "<e1>", ")", "and", "long-term", "prognosis", "was", "studied", "in", "1,850", "C1332416#ent", "<e2>", "patients", "of", "acute", "myocardial", "infarction", "AMI", ")", "."], "h": {"id": "C0059036", "name": "C0059036#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [31, 32]}}
{"token": ["FasL", "is", "cleaved", "by", "a", "C1334706#ent", "<e1>", "and", "released", "in", "serum", "as", "soluble", "FasL", "(", "C1539478#ent", "<e2>", ")", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [15, 16]}}
{"token": ["Several", "recent", "studies", "have", "shown", "that", "some", "C1334706#ent", "<e1>", "mediates", "TNF-alpha", "and", "C1539478#ent", "<e2>", "processing", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [12, 13]}}
{"token": ["C0002502#ent", "<e1>", ",", "a", "specific", "NHE", "1", "inhibitor", ",", "and", "C0075193#ent", "<e2>", "a", "protein", "kinase", "C", "inhibitor", "used", "to", "inhibit", "erythrocyte", "NHE", "1", "."], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [10, 11]}}
{"token": ["Aspergillus", "causes", "a", "spectrum", "of", "diseases", ",", "among", "which", "C0004030#ent", "<e1>", "(", "saprophytic", "colonization", ")", "and", "allergic", "bronchopulmonary", "aspergillosis", "C2982413#ent", "<e2>", ")", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2982413", "name": "C2982413#ent", "pos": [19, 20]}}
{"token": ["Other", "diagnoses", "in", "individual", "patients", "included", "Pick's", "disease", "corticobasal", "degeneration", "other", "tauopathies", ",", "Lewy", "body", "dementia", "multiple", "sclerosis", "Whipple's", "disease", "progressive", "C0023524#ent", "<e1>", "cerebral", "autosomal", "arteriopathy", "with", "subcortical", "ischaemic", "leucoencephalopathy", "vasculopathies", "and", "C0085584#ent", "<e2>"], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [21, 22]}, "relation": "has_nichd_parent", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [32, 33]}}
{"token": ["C2975114#ent", "<e1>", "at", "sufficient", "temperature", "permitted", "to", "decompose", "the", "C0007026#ent", "<e2>", "to", "benefit", "of", "a", "barium", "silicate"], "h": {"id": "C2975114", "name": "C2975114#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007026", "name": "C0007026#ent", "pos": [9, 10]}}
{"token": ["Open", "reading", "frame", "71", "C0013570#ent", "<e1>", "71", ")", "of", "Kaposi's", "sarcoma-associated", "herpesvirus", "KSHV", ")", "encodes", "a", "C1428374#ent", "<e2>", "is", "homologous", "to", "cellular", "FLIPs", "(", "FLICE-inhibitory", "proteins", "and", "is", "proposed", "to", "inhibit", "Fas-mediated", "apoptosis", "."], "h": {"id": "C0013570", "name": "C0013570#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428374", "name": "C1428374#ent", "pos": [16, 17]}}
{"token": ["Several", "causes", "have", "been", "held", "responsible", "for", "the", "chronic", "fatigue", "syndrome", "C0015674#ent", "<e1>", ")", ",", "including", "an", "altered", "hypothalamus-pituitary-adrenal", "gland", "activity", ",", "C0042769#ent", "<e2>", "a", "reduced", "Th1", "activity", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [22, 23]}}
{"token": ["1", ")", "Although", "C0015674#ent", "<e1>", "is", "often", "associated", "with", "C0042769#ent", "<e2>", "the", "presence", "of", "viruses", "has", "as", "yet", "not", "consistently", "been", "detected", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}}
{"token": ["The", "pattern", "of", "abnormalities", "reported", "in", "immunological", "testing", "patients", "with", "C0015674#ent", "<e1>", "is", "consistent", "with", "changes", "seen", "during", "the", "resolving", "phases", "of", "C0042769#ent", "<e2>"], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [22, 23]}}
{"token": ["The", "objectives", "of", "this", "study", "were", "to", "investigate", "the", "lifetime", "prevalence", "of", "epileptic", "seizures", "a", "population", "with", "C0162565#ent", "<e1>", "AIP", ")", "and", "to", "characterize", "the", "C0036572#ent", "<e2>", "and", "the", "seizure-triggering", "factors", "."], "h": {"id": "C0162565", "name": "C0162565#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [25, 26]}}
{"token": ["The", "C0059181#ent", "<e1>", "pattern", "shows", "that", "the", "C0086661#ent", "<e2>", "DNA", "region", "undermethylated", "and", "that", "the", "c-abl", "gene", "hypermethylated", "both", "before", "and", "after", "the", "erythroid", "induction", "."], "h": {"id": "C0059181", "name": "C0059181#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [7, 8]}}
{"token": ["Osteoporosis", ",", "joint-space", "narrowing", ",", "and", "joint", "destruction", "less", "frequently", "in", "patients", "with", "C0152262#ent", "<e1>", "in", "patients", "with", "classic", "C0003873#ent", "<e2>", "."], "h": {"id": "C0152262", "name": "C0152262#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["To", "compare", "the", "efficacy", "and", "tolerability", "of", "C0017245#ent", "<e1>", "and", "Bezafibrate", "in", "patients", "with", "C0020476#ent", "<e2>", ",", "types", "IIa", "IIb", "and", "IV", "."], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [14, 15]}}
{"token": ["C0017245#ent", "<e1>", "was", "found", "to", "be", "an", "effective", "hypotriglyceridaemic", "agent", "types", "IV", "C0020476#ent", "<e2>"], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [12, 13]}}
{"token": ["C1423062#ent", "<e1>", "are", "NAD(+)-dependent", "protein", "deacetylases", "that", "are", "involved", "in", "C1710463#ent", "<e2>", "metabolism", ",", "apoptosis", ",", "differentiation", "and", "ageing", "."], "h": {"id": "C1423062", "name": "C1423062#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [10, 11]}}
{"token": ["Mutagenesis", "of", "the", "binding", "site", "that", "C1706445#ent", "<e1>", "contributes", "significantly", "to", "the", "C0669365#ent", "<e2>", "the", "ori-Lyt", "enhancer", "."], "h": {"id": "C1706445", "name": "C1706445#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}}
{"token": ["GPs", "envisaged", "that", "patient", "education", "be", "a", "major", "problem", "in", "establishing", "a", "C0011849#ent", "<e1>", "but", "only", "58", "%", "identified", "education", "as", "a", "C0310298#ent", "<e2>", "that", "could", "be", "accomplished", "by", "the", "practice", "nurse"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [22, 23]}}
{"token": ["Aspirin", "remains", "the", "agent", "of", "first", "choice", ",", "but", "ibuprofen", ",", "C0015837#ent", "<e1>", ",", "naproxen", "and", "C0087097#ent", "<e2>", "are", "useful", "drugs", "in", "rheumatoid", "arthritis"], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0087097", "name": "C0087097#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "rule", "out", "C1334064#ent", "<e1>", "a", "carnosinase", ",", "non-serine", "esterase", ",", "plasminogen", "activator", "collagenase", "or", "C0162745#ent", "<e2>", "suggest", "that", "it", "is", "a", "chymotrypsin-like", "protease"], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [16, 17]}}
{"token": ["To", "identify", "cation", "requirements", "of", "the", "ATP-induced", "process", ",", "C3273508#ent", "<e1>", "monocytes", "were", "treated", "with", "C1705556#ent", "<e2>", "in", "media", "containing", "different", "Cl-", "salts", "or", "sucrose", "."], "h": {"id": "C3273508", "name": "C3273508#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [15, 16]}}
{"token": ["C0221014#ent", "<e1>", "be", "seen", "as", "a", "rare", "complication", "of", "Crohn's", "disease", "C0009324#ent", "<e2>"], "h": {"id": "C0221014", "name": "C0221014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [11, 12]}}
{"token": ["C0221014#ent", "<e1>", "inflammatory", "bowel", "disease", "a", "rare", "event", ",", "in", "case", "of", "C0009324#ent", "<e2>", "true", "curiosity", "."], "h": {"id": "C0221014", "name": "C0221014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [12, 13]}}
{"token": ["Stimulation", "of", "CD4", "on", "Thp-1", "monocytic", "cells", "induced", "a", "C0001477#ent", "<e1>", "flux", "and", "the", "time-dependent", "activation", "of", "C0085536#ent", "<e2>", "from", "35", "to", "180", "kDa", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [17, 18]}}
{"token": ["Release", "of", "intracellular", "Ca2", "+", "stores", "by", "thapsigargin", ",", "a", "C0001477#ent", "<e1>", "was", ",", "however", ",", "found", "to", "increase", "the", "C0085536#ent", "<e2>", "content", "of", "the", "same", "60", "and", "110", "kD", "proteins", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [20, 21]}}
{"token": ["In", "this", "report", ",", "a", "case", "with", "vitamin", "B12", "deficiency", "a", "temporary", "confusion", "depending", "on", "the", "usage", "of", "C0540623#ent", "<e1>", "during", "the", "C0149931#ent", "<e2>", "attack", "was", "presented", "."], "h": {"id": "C0540623", "name": "C0540623#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [22, 23]}}
{"token": ["C0540623#ent", "<e1>", "is", "a", "novel", "5-HT1", "agonist", "to", "treat", "C0149931#ent", "<e2>"], "h": {"id": "C0540623", "name": "C0540623#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [9, 10]}}
{"token": ["Instead", "C1332725#ent", "<e1>", "directly", "binds", "a", "HECT-family", "ubiquitin", "E3", "ligase", "C1537395#ent", "<e2>", "(", "also", "known", "as", "Mule", ",", "UreB1", ",", "ARF-BP1", ",", "Lasu1", ",", "and", "HectH9", ")", ",", "and", "C1537395#ent", "<e2>", "polyubiquitinates", "C1332725#ent", "<e1>", "in", "vitro"], "h": {"id": "C1332725", "name": "C1332725#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1537395", "name": "C1537395#ent", "pos": [10, 11]}}
{"token": ["In", "general", ",", "it", "is", "possible", "to", "predict", "the", "therapeutic", "outcome", "especially", "in", "C0019693#ent", "<e1>", "infected", "patients", "with", "oropharyngeal", "candidiasis", "treated", "with", "C0016277#ent", "<e2>", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [22, 23]}}
{"token": ["Itraconazole", "may", "still", "serve", "as", "an", "effective", "antifungal", "agent", "patients", "with", "C0019693#ent", "<e1>", "oropharyngeal", "candidosis", "nonresponsive", "to", "C0016277#ent", "<e2>", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [17, 18]}}
{"token": ["These", "data", "demonstrate", "that", "C0003949#ent", "<e1>", "caused", "fiber-specific", "activation", "of", "C0669365#ent", "<e2>", "and", "pulmonary", "epithelial", "cells", "resulting", "in", "phenotypes", "capable", "of", "facilitating", "tissue", "remodeling"], "h": {"id": "C0003949", "name": "C0003949#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [10, 11]}}
{"token": ["Fuller", "understanding", "of", "C0019348#ent", "<e1>", "persistence", "and", "recurrent", "C0752235#ent", "<e2>", "survivors", "will", "require", "further", "studies", "using", "these", "and", "other", "techniques", "in", "human", "tissues", "and", "in", "animal", "models"], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [8, 9]}}
{"token": ["In", "the", "present", "study", ",", "we", "have", "examined", "the", "effects", "of", "systemic", "treatment", "C0123163#ent", "<e1>", "on", "the", "neurotoxic", "consequences", "of", "intrastriatal", "injection", "of", "kainic", "acid", "C0080074#ent", "<e2>", "or", "quinolinic", "acid", "an", "NMDA", "receptor", "agonist", "on", "neuronal", "degeneration"], "h": {"id": "C0123163", "name": "C0123163#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0080074", "name": "C0080074#ent", "pos": [25, 26]}}
{"token": ["The", "present", "replication", "study", "the", "initial", "finding", "that", "the", "C1416577#ent", "<e1>", "Cys271", "allele", "is", "associated", "with", "seizure", "resistance", "common", "syndromes", "of", "idiopathic", "generalized", "epilepsy", "C1415975#ent", "<e2>", ")", "."], "h": {"id": "C1416577", "name": "C1416577#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [24, 25]}}
{"token": ["Human", "herpes", "simplex", "virus", "type-1", "HSV-1", ")", "is", "treatable", "with", "oral", "doses", "an", "C0003451#ent", "<e1>", "as", "aciclovir", "(", "ACV", ")", ",", "a", "C1254351#ent", "<e2>", "that", "has", "poor", "bioavailability"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [22, 23]}}
{"token": ["It", "was", "also", "found", "that", "all", "structures", "within", "the", "cytoplasm", "possessed", "a", "1", "-", "3", "layer", "intact", "C0017343#ent", "<e1>", "and", "there", "was", "C0008546#ent", "<e2>", "in", "the", "nucleus", "."], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [22, 23]}}
{"token": ["Oxidative", "stress", "by", "crystalline", "silica", "is", "also", "evidenced", "by", "increased", "expression", "of", "antioxidant", "enzymes", "as", "manganese", "superoxide", "dismutase", "Mn-SOD", ")", "and", "C0017822#ent", "<e1>", "and", "the", "C1533698#ent", "<e2>", "iNOS", ")", "."], "h": {"id": "C0017822", "name": "C0017822#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [25, 26]}}
{"token": ["Renal", "failure", "cases", "of", "lymphoma", "is", "secondary", "to", "ureteral", "obstruction", "hypercalcaemia", ",", "urate", "nephropathy", "C0272247#ent", "<e1>", "or", "immunologically", "mediated", "C0027720#ent", "<e2>", "."], "h": {"id": "C0272247", "name": "C0272247#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027720", "name": "C0027720#ent", "pos": [19, 20]}}
{"token": ["Gastroduodenoscopy", "also", "detected", "adverse", "NSAID-effects", "on", "the", "upper", "gastrointestinal", "tract", "patient", "1", "3", "(", "C0149745#ent", "<e1>", "of", "the", "stomach", ",", "C0341245#ent", "<e2>", "."], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0341245", "name": "C0341245#ent", "pos": [20, 21]}}
{"token": ["Application", "of", "multilocus", "enzyme", "electrophoresis", "comparative", "sequencing", "the", "C0079429#ent", "<e1>", "(", "speA", ")", "encoding", "streptococcal", "pyrogenic", "exotoxin", "A", "C0036285#ent", "<e2>", "revealed", "that", "new", "waves", "of", "scarlet", "fever", "associated", "with", "increase", "in", "frequency", "of", "S.", "pyogenes", "clones", "carrying", "variant", "speA", "alleles", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036285", "name": "C0036285#ent", "pos": [18, 19]}}
{"token": ["Trimetrexate", ",", "rather", "than", "methotrexate", ",", "was", "used", "as", "the", "selecting", "agent", "to", "increase", "the", "probability", "of", "obtaining", "mutations", "in", "C3853636#ent", "<e1>", "rather", "than", "in", "the", "reduced", "C2957112#ent", "<e2>"], "h": {"id": "C3853636", "name": "C3853636#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2957112", "name": "C2957112#ent", "pos": [27, 28]}}
{"token": ["Retention", "of", "C0015310#ent", "<e1>", "C0002085#ent", "<e2>", "during", "reduction", "in", "the", "number", "of", "C0002085#ent", "<e2>", "violates", "assumptions", "of", "the", "coalescent", "model", "used", "to", "estimate", "effective", "population", "size"], "h": {"id": "C0015310", "name": "C0015310#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [4, 5]}}
{"token": ["These", "data", "are", "consistent", "with", "an", "extremely", "C0015310#ent", "<e1>", "family", "of", "DQA3", "genes", "or", "an", "C0002085#ent", "<e2>", "at", "an", "additional", "BoLA", "DQA4", "locus", "."], "h": {"id": "C0015310", "name": "C0015310#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [15, 16]}}
{"token": ["C0920270#ent", "<e1>", ",", "a", "member", "of", "the", "C0017347#ent", "<e2>", "genes", ",", "has", "been", "shown", "to", "play", "a", "role", "in", "T-ALL", "."], "h": {"id": "C0920270", "name": "C0920270#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017347", "name": "C0017347#ent", "pos": [7, 8]}}
{"token": ["Mice", "in", "which", "all", "members", "of", "the", "Hox10", "or", "C0920270#ent", "<e1>", "paralogous", "group", "are", "disrupted", "provide", "evidence", "that", "these", "C0017347#ent", "<e2>", "involved", "in", "global", "patterning", "of", "the", "axial", "and", "appendicular", "skeleton"], "h": {"id": "C0920270", "name": "C0920270#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017347", "name": "C0017347#ent", "pos": [19, 20]}}
{"token": ["Comparative", "promoter", "and", "homeodomain", "sequence", "analyses", "that", "it", "is", "related", "to", "the", "C0920270#ent", "<e1>", "which", "belongs", "to", "the", "C0017347#ent", "<e2>"], "h": {"id": "C0920270", "name": "C0920270#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017347", "name": "C0017347#ent", "pos": [18, 19]}}
{"token": ["We", "have", "found", "that", "the", "major", "M.", "tuberculosis", "cell", "wall", "glycolipid", "phosphatidylinositol", "mannoside", "C0812214#ent", "<e1>", ")", ",", "induces", "homotypic", "adhesion", "human", "CD4+", "T", "cells", "T", "cell", "adhesion", "immobilized", "C1367472#ent", "<e2>", "."], "h": {"id": "C0812214", "name": "C0812214#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1367472", "name": "C1367472#ent", "pos": [28, 29]}}
{"token": ["Analogy", "is", "drawn", "to", "C0035439#ent", "<e1>", "RHD", ")", ",", "a", "known", "sequela", "of", "C0036689#ent", "<e2>"], "h": {"id": "C0035439", "name": "C0035439#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036689", "name": "C0036689#ent", "pos": [13, 14]}}
{"token": ["Sulpiride", "was", "slightly", "more", "potent", "than", "C0040180#ent", "<e1>", "which", "was", "more", "than", "10", "times", "more", "potent", "than", "C0025853#ent", "<e2>", "and", "haloperidol", "."], "h": {"id": "C0040180", "name": "C0040180#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [17, 18]}}
{"token": ["The", "detection", "limits", "S/N", "=", "3", ")", "for", "sulpiride", ",", "C0040180#ent", "<e1>", ",", "sultopride", "and", "C0025853#ent", "<e2>", "are", "1", "ng/ml", ",", "4", "ng/ml", ",", "2", "ng/ml", "and", "0.5", "ng/ml", ",", "respectively", "."], "h": {"id": "C0040180", "name": "C0040180#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [15, 16]}}
{"token": ["C0040180#ent", "<e1>", ",", "a", "substituted", "benzamide", "derivative", "closely", "related", "to", "C0025853#ent", "<e2>", ",", "reduced", "levodopa-induced", "peak", "dose", "involuntary", "movements", "16", "patients", "with", "idiopathic", "Parkinson's", "disease"], "h": {"id": "C0040180", "name": "C0040180#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [10, 11]}}
{"token": ["For", "these", "studies", ",", "we", "generated", "transgenic", "mice", "overexpressed", "human", "BCL2", "under", "control", "of", "C0968461#ent", "<e1>", "MyoD", "or", "C1417533#ent", "<e2>", "promoter", "fragments"], "h": {"id": "C0968461", "name": "C0968461#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417533", "name": "C1417533#ent", "pos": [18, 19]}}
{"token": ["C0020807#ent", "<e1>", "known", "to", "cause", "C0034069#ent", "<e2>", "secondary", "to", "recurrent", "alveolar", "hemorrhage", "deposition", "of", "hemosiderin", "in", "the", "interstitium", "."], "h": {"id": "C0020807", "name": "C0020807#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "pDC", "counts", "in", "C1332077#ent", "<e1>", "from", "immunocompromised", "patients", "with", "C0032285#ent", "<e2>", "were", "even", "lower", "than", "in", "controls", "."], "h": {"id": "C1332077", "name": "C1332077#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}}
{"token": ["Further", ",", "we", "demonstrate", "that", "the", "induction", "of", "apoptosis", "in", "EAT", "cells", "nuclear", "condensation", "DNA", "fragmentation", "translocation", "of", "C1413983#ent", "<e1>", "CAD", ")", "to", "nucleus", "upon", "C4055175#ent", "<e2>", "treatment", "."], "h": {"id": "C1413983", "name": "C1413983#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4055175", "name": "C4055175#ent", "pos": [25, 26]}}
{"token": ["Southern", "blot", "analysis", "single-copy", "C1420167#ent", "<e1>", "genes", "in", "the", "mouse", "and", "human", "C0017428#ent", "<e2>", "."], "h": {"id": "C1420167", "name": "C1420167#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [12, 13]}}
{"token": ["Using", "C1q-blocking", "and", "MBL-blocking", "mAb", ",", "it", "was", "confirmed", "that", "both", "the", "C2239920#ent", "<e1>", "and", "the", "CP", "contribute", "to", "complement", "activation", "C0053413#ent", "<e2>", "."], "h": {"id": "C2239920", "name": "C2239920#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0053413", "name": "C0053413#ent", "pos": [21, 22]}}
{"token": ["With", "increasing", "frequency", ",", "patients", "with", "impaired", "humoral", "immunity", "been", "shown", "to", "have", "a", "C0026936#ent", "<e1>", "results", "in", "C3714636#ent", "<e2>", ",", "sinusitis", ",", "cystitis", ",", "arthritis", ",", "osteomyelitis", ",", "or", "cellulitis", "."], "h": {"id": "C0026936", "name": "C0026936#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [18, 19]}}
{"token": ["Activation", "of", "the", "C1707072#ent", "<e1>", "cleavage", "of", "its", "substrate", "poly(ADP-ribose)polymerase", "C1567710#ent", "<e2>", ")", "was", "also", "detected", "in", "Fas-S", "but", "not", "Fas-R", "lines", "."], "h": {"id": "C1707072", "name": "C1707072#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1567710", "name": "C1567710#ent", "pos": [10, 11]}}
{"token": ["MYH9", "disorders", "are", "autosomal-dominant", "macrothrombocytopenias", "leukocyte", "inclusions", "caused", "by", "mutations", "in", "the", "C3273546#ent", "<e1>", "which", "encodes", "the", "C1417544#ent", "<e2>", "NMMHCA", ")", "."], "h": {"id": "C3273546", "name": "C3273546#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417544", "name": "C1417544#ent", "pos": [17, 18]}}
{"token": ["The", "three", "C0301713#ent", "<e1>", "phenylalanine", ",", "tyrosine", ",", "and", "C1420870#ent", "<e2>", "and", "nitric", "oxide", "synthase", "NOS", ")", "all", "utilize", "(6R)-l-erythro-5,6,7,8-tetrahydrobiopterin", "(", "BH(4", ")", ")", "as", "cofactor", "."], "h": {"id": "C0301713", "name": "C0301713#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [9, 10]}}
{"token": ["This", "highly", "conserved", "region", "of", "the", "C0301713#ent", "<e1>", "11", "out", "of", "17", "amino", "acids", "identical", "in", "phenylalanine", "hydroxylase", "tyrosine", "hydroxylase", "C1420870#ent", "<e2>"], "h": {"id": "C0301713", "name": "C0301713#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [20, 21]}}
{"token": ["That", "very", "similar", "affinities", "were", "observed", "when", "either", "C0022614#ent", "<e1>", "or", "glycine", "was", "present", "suggests", "that", "C0066057#ent", "<e2>", "exerted", "a", "direct", "action", "at", "the", "PCP", "site", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0066057", "name": "C0066057#ent", "pos": [16, 17]}}
{"token": ["The", "stress-sensitive", "phenotypes", "of", "strains", "lacking", "these", "C1417679#ent", "<e1>", "reveal", "a", "hitherto", "unknown", "link", "between", "C1420654#ent", "<e2>", "environmental", "stress", "sensitivity", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420654", "name": "C1420654#ent", "pos": [15, 16]}}
{"token": ["CYP2E1", "was", "strongly", "correlated", "with", "C0008161#ent", "<e1>", "formation", "from", "C0040905#ent", "<e2>", ";", "CYP2B", "displayed", "the", "strongest", "correlation", "with", "trichloroethanol", "formation", "."], "h": {"id": "C0008161", "name": "C0008161#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040905", "name": "C0040905#ent", "pos": [9, 10]}}
{"token": ["C0008161#ent", "<e1>", "the", "final", "rearrangement", "product", "C0040905#ent", "<e2>", "is", "determined", "by", "electron-capture", "gas", "chromatography", ",", "either", "after", "derivatization", "with", "pentafluorophenylhydrazine", "or", "after", "its", "conversion", "into", "chloroform", "under", "alkaline", "conditions", "."], "h": {"id": "C0008161", "name": "C0008161#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040905", "name": "C0040905#ent", "pos": [6, 7]}}
{"token": ["Characterization", "by", "multiple", "ion", "monitoring", ",", "for", "the", "first", "time", ",", "that", "C0008161#ent", "<e1>", "as", "a", "transient", "metabolite", "of", "C0040905#ent", "<e2>", "in", "man", "."], "h": {"id": "C0008161", "name": "C0008161#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040905", "name": "C0040905#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "monochloroacetic", "acid", "C0008161#ent", "<e1>", "and", "trichloroacetic", "acid", "been", "found", "in", "reaction", "mixtures", "C0040905#ent", "<e2>", ",", "trichloroethylene", ",", "and", "tetrachloroethylene", ",", "respectively", ",", "with", "rat", "liver", "microsomal", "systems", "."], "h": {"id": "C0008161", "name": "C0008161#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040905", "name": "C0040905#ent", "pos": [14, 15]}}
{"token": ["Combination", "of", "C1742019#ent", "<e1>", "prednisolone", "did", "not", "increase", "absorption", "of", "either", "C0013227#ent", "<e2>", "."], "h": {"id": "C1742019", "name": "C1742019#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [11, 12]}}
{"token": ["Expansions", "of", "simple", "DNA", "repeats", "responsible", "for", "more", "than", "two", "dozen", "C0019247#ent", "<e1>", "humans", ",", "including", "C0016667#ent", "<e2>", "myotonic", "dystrophy", "Huntington's", "disease", "various", "spinocerebellar", "ataxias", "Friedreich's", "ataxia", "others", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0016667", "name": "C0016667#ent", "pos": [16, 17]}}
{"token": ["Together", ",", "the", "results", "provide", "evidence", "for", "autoinhibition", "of", "a", "C0597721#ent", "<e1>", "identify", "JH2", "regions", "important", "for", "autoregulation", "of", "C1527617#ent", "<e2>", "."], "h": {"id": "C0597721", "name": "C0597721#ent", "pos": [10, 11]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C1527617", "name": "C1527617#ent", "pos": [19, 20]}}
{"token": ["In", "C0011991#ent", "<e1>", "severe", "forms", "of", "C0021051#ent", "<e2>", "patients", "receiving", "LC1", "were", "disease-free", "for", "about", "4", "weeks", "but", "the", "response", "may", "be", "lower", "in", "patients", "with", "AIDS", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [6, 7]}}
{"token": ["C0011991#ent", "<e1>", "frequent", "in", "acquired", "C0021051#ent", "<e2>", "AIDS", ")", "but", "has", "been", "poorly", "investigated", "so", "far", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [5, 6]}}
{"token": ["They", "account", "for", "a", "substantial", "proportion", "of", "C0011991#ent", "<e1>", "malabsorption", "in", "acquired", "C0021051#ent", "<e2>", "but", "their", "appearance", "after", "solid", "organ", "transplantation", "only", "rarely", "been", "reported", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [12, 13]}}
{"token": ["One", "patient", "was", "re-challenged", "with", "C0028156#ent", "<e1>", ",", "which", "resulted", "in", "recurrence", "of", "elevated", "C0002594#ent", "<e2>", "nine", "weeks", "medication", "."], "h": {"id": "C0028156", "name": "C0028156#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [14, 15]}}
{"token": ["Primary", "cultures", "rat", "hepatocytes", "exposed", "to", "tert-butyl", "hydroperoxide", "t-BHP", ")", "were", "used", "for", "characterizing", "the", "antioxidative", "and", "C1512412#ent", "<e1>", "potential", "of", "C1365494#ent", "<e2>", "AK", ".", ")"], "h": {"id": "C1512412", "name": "C1512412#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1365494", "name": "C1365494#ent", "pos": [21, 22]}}
{"token": ["The", "increase", "in", "C0009325#ent", "<e1>", "was", "prevented", "by", "antioxidants", "and", "a", "C0919426#ent", "<e2>"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0919426", "name": "C0919426#ent", "pos": [11, 12]}}
{"token": ["There", "was", "also", "a", "decrease", "in", "the", "CYP2E1", "mRNA", "and", "in", "C0009325#ent", "<e1>", ",", "with", "similar", "trends", "for", "C0919426#ent", "<e2>", "procollagen", "mRNA", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0919426", "name": "C0919426#ent", "pos": [18, 19]}}
{"token": ["Renal", "IGF", "I", "production", "is", "stimulated", "by", "growth", "hormone", "C1333673#ent", "<e1>", ")", "and", "by", "epidermal", "growth", "factor", "C1367721#ent", "<e2>", ")", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [17, 18]}}
{"token": ["The", "direct", "effects", "of", "insulin", ",", "C1333673#ent", "<e1>", ",", "IGFs", ",", "basic", "FGF", "and", "C1367721#ent", "<e2>", "on", "transplant", "growth", "tissue", "differentiation", "evaluated", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [14, 15]}}
{"token": ["The", "main", "epidemiological", "features", "in", "both", "groups", "were", "underlying", "bacterial", "diseases", "i.e.", "otomastoiditis", "and/or", "C0037199#ent", "<e1>", "in", "50", "%", "of", "pneumococcal", "meningitis", "and", "C0221026#ent", "<e2>"], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0221026", "name": "C0221026#ent", "pos": [23, 24]}}
{"token": ["Inspection", "of", "the", "nucleotide", "sequence", "that", "there", "is", "an", "open", "reading", "frame", "upstream", "of", "the", "C1417869#ent", "<e1>", "suggesting", "that", "it", "might", "be", "part", "of", "an", "C0029073#ent", "<e2>", "."], "h": {"id": "C1417869", "name": "C1417869#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [25, 26]}}
{"token": ["Retinal", "glial", "(", "M\u00fcller", ")", "cells", "may", "play", "a", "major", "role", "in", "C0015397#ent", "<e1>", "they", "secrete", "C1522575#ent", "<e2>", "VEGF", ")", ",", "a", "hypoxia-induced", "angiogenic", "cytokine", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "epiretinal", "membranes", "proliferative", "C0015397#ent", "<e1>", "the", "presence", "of", "vascular", "endothelial", "growth", "factor", "C1522575#ent", "<e2>", ")", "and", "tumor", "necrosis", "factor", "alpha", "TNF-alpha", ")", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [14, 15]}}
{"token": ["The", "C2917660#ent", "<e1>", "composition", "of", "C2699120#ent", "<e2>", "showed", "a", "high", "content", "of", "glutamic", "acid/glutamine", "and", "no", "methionine", ",", "tryptophan", ",", "tyrosine", ",", "phenylalanine", ",", "or", "histidine", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2699120", "name": "C2699120#ent", "pos": [5, 6]}}
{"token": ["Bacterial", "lipopolysaccharide", "C2697656#ent", "<e1>", ")", "induces", "a", "C2936489#ent", "<e2>", "the", "immune", "system", "might", "subsequently", "result", "in", "septic", "shock"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936489", "name": "C2936489#ent", "pos": [7, 8]}}
{"token": ["Lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", ",", "a", "potent", "and", "C2936489#ent", "<e2>", "immune", "cells", "binds", "to", "neutrophils", "via", "CD14", ",", "but", "less", "densely", "than", "to", "monocytes", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936489", "name": "C2936489#ent", "pos": [9, 10]}}
{"token": ["Bacterial", "lipopolysaccharide", "C2697656#ent", "<e1>", ")", "is", "a", "potent", "and", "C2936489#ent", "<e2>", "immune", "cells"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936489", "name": "C2936489#ent", "pos": [9, 10]}}
{"token": ["Immunohistochemistry", "was", "performed", "to", "localize", "the", "microsomal", "form", "of", "C0014628#ent", "<e1>", "mEH", ")", "and", "C0769262#ent", "<e2>", "mu", "and", "pi", "in", "the", "rodent", "olfactory", "mucosa"], "h": {"id": "C0014628", "name": "C0014628#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0769262", "name": "C0769262#ent", "pos": [14, 15]}}
{"token": ["Cytochrome", "P450", "present", "in", "only", "a", "small", "proportion", "of", "normal", "colon", "samples", ",", "whereas", "C0014628#ent", "<e1>", "glutathione", "S-transferase", "mu", "identified", "in", "about", "half", ",", "and", "C0769262#ent", "<e2>", "pi", "in", "most", "normal", "samples", "."], "h": {"id": "C0014628", "name": "C0014628#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0769262", "name": "C0769262#ent", "pos": [25, 26]}}
{"token": ["Efforts", "of", "many", "laboratories", "have", "identified", "Branchless", "(", "Bnl", ",", "a", "C1414598#ent", "<e1>", "and", "Breathless", "(", "C1413390#ent", "<e2>", ",", "the", "receptor", "homologue", "as", "crucial", "factors", "at", "many", "stages", "of", "tracheal", "system", "development", "."], "h": {"id": "C1414598", "name": "C1414598#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413390", "name": "C1413390#ent", "pos": [16, 17]}}
{"token": ["The", "response", "of", "atrial", "natriuretic", "peptide", "ANP", ")", "to", "standing", "and", "the", "acute", "and", "chronic", "administration", "the", "vasodilator", ",", "C0006938#ent", "<e1>", ",", "were", "examined", "in", "15", "patients", "with", "C0264722#ent", "<e2>"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0264722", "name": "C0264722#ent", "pos": [28, 29]}}
{"token": ["We", "present", "evidence", "that", "gigaxonin", "binds", "to", "the", "ubiquitin-activating", "enzyme", "E1", "its", "amino-terminal", "BTB", "domain", "while", "the", "carboxy-terminal", "kelch", "repeat", "domain", "interacts", "directly", "with", "the", "C0806492#ent", "<e1>", "LC", ")", "of", "microtubule-associated", "protein", "1B", "C1417004#ent", "<e2>", ")", "."], "h": {"id": "C0806492", "name": "C0806492#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1417004", "name": "C1417004#ent", "pos": [33, 34]}}
{"token": ["One", "complication", "at", "primary", "diagnosis", "C0282548#ent", "<e1>", ",", "which", "usually", "causes", "respiratory", ",", "retinal", ",", "or", "C2828177#ent", "<e2>"], "h": {"id": "C0282548", "name": "C0282548#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2828177", "name": "C2828177#ent", "pos": [16, 17]}}
{"token": ["Interindividual", "variations", "suggest", "that", "each", "C0234533#ent", "<e1>", "has", "his", "own", "pathological", "neuronal", "organisation", "which", "C0001614#ent", "<e2>", "and", "thalamocortical", "connexions", "are", "variously", "sensitive", "to", "the", "neurotransmitters", "implicated", "in", "sleep", "and", "waking", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [14, 15]}}
{"token": ["To", "study", "seizure-induced", "changes", "in", "signaling", "proteins", "in", "postsynaptic", "densities", "PSDs", ")", "isolated", "from", "human", "C0234533#ent", "<e1>", "neocortex", "and", "from", "rat", "C0001614#ent", "<e2>", "in", "which", "seizures", "were", "induced", "by", "injection", "of", "kainic", "acid"], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [21, 22]}}
{"token": ["Yeasts", "bearing", "a", "disruption", "of", "the", "C1336575#ent", "<e1>", "gene", "lack", "significant", "biochemically", "detectable", "C1416943#ent", "<e2>", "activity", "."], "h": {"id": "C1336575", "name": "C1336575#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416943", "name": "C1416943#ent", "pos": [13, 14]}}
{"token": ["To", "review", "the", "incidence", "of", "reversible", "C1565489#ent", "<e1>", "patients", "with", "C0027719#ent", "<e2>", "antihypertensive", "therapy"], "h": {"id": "C1565489", "name": "C1565489#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027719", "name": "C0027719#ent", "pos": [10, 11]}}
{"token": ["We", "identified", "C1418423#ent", "<e1>", "splicing", "variants", "that", "expressed", "in", "C1416400#ent", "<e2>", "or", "primary", "calvarial", "osteoblasts", "by", "rapid", "amplification", "of", "the", "5'-ends", "of", "cDNA", "when", "they", "were", "cultured", "with", "BMP", "."], "h": {"id": "C1418423", "name": "C1418423#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416400", "name": "C1416400#ent", "pos": [9, 10]}}
{"token": ["Restless", "legs", "syndrome", "RLS", ")", "is", "a", "common", "C0393777#ent", "<e1>", "characterised", "by", "C0030554#ent", "<e2>", "associated", "with", "irresistible", "urge", "to", "move", "."], "h": {"id": "C0393777", "name": "C0393777#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030554", "name": "C0030554#ent", "pos": [12, 13]}}
{"token": ["In", "human", "U937", "monocytes", ",", "hydrogen", "peroxide", "H(2)O(2", ")", ")", "evokes", "Ca(2+)", "influx", "through", "C1421174#ent", "<e1>", "to", "activate", "Ca(2+)-dependent", "tyrosine", "kinase", "C1705341#ent", "<e2>", "and", "amplify", "Erk", "signaling", "Ras", "GTPase"], "h": {"id": "C1421174", "name": "C1421174#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [21, 22]}}
{"token": ["Possible", "causes", "for", "the", "development", "of", "resistance", "in", "C0019348#ent", "<e1>", "the", "use", "of", "C0209227#ent", "<e2>", "and", "forscarnet", "as", "two", "therapeutic", "alternatives", "to", "aciclovir", "are", "discussed", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0209227", "name": "C0209227#ent", "pos": [13, 14]}}
{"token": ["Postsurgical", "C0019348#ent", "<e1>", "infection", "rates", "in", "patients", "receiving", "C0209227#ent", "<e2>", "compared", "with", "those", "from", "a", "similar", "historical", "control", "of", "HSV-positive", "patients", "(", "n", "=", "127", ")", "who", "received", "no", "prophylaxis"], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [1, 2]}, "relation": "may_be_prevented_by", "t": {"id": "C0209227", "name": "C0209227#ent", "pos": [8, 9]}}
{"token": ["Hypoxia", "alone", "did", "not", "induce", "C3890018#ent", "<e1>", "transcription", "in", "these", "cells", "despite", "a", "significant", "depression", "in", "C1705556#ent", "<e2>", "."], "h": {"id": "C3890018", "name": "C3890018#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [16, 17]}}
{"token": ["Two", "different", "antibodies", "raised", "to", "C1413290#ent", "<e1>", "purified", "virtually", "identical", "kinase", "activities", "as", "analysed", "by", "MBP", "C0031684#ent", "<e2>", "mapping", "and", "phosphoamino", "acid", "analysis"], "h": {"id": "C1413290", "name": "C1413290#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031684", "name": "C0031684#ent", "pos": [16, 17]}}
{"token": ["Over", "the", "first", "3", "years", "of", "surveillance", "(", "1990", "-", "1992", ")", ",", "132", "cases", "of", "C2350529#ent", "<e1>", "have", "been", "registered", "as", "probably", "invasive", "and", "C0205721#ent", "<e2>", "."], "h": {"id": "C2350529", "name": "C2350529#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0205721", "name": "C0205721#ent", "pos": [25, 26]}}
{"token": ["Some", "animals", "responded", "to", "only", "one", "of", "the", "selective", "dopamine", "agonists", "but", "all", "responded", "to", "C0003596#ent", "<e1>", "and", "to", "the", "combination", "of", "SK&F", "38393", "C1135604#ent", "<e2>", "SK&F", "38393", "quinpirole", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1135604", "name": "C1135604#ent", "pos": [24, 25]}}
{"token": ["Median", "response", "C2926735#ent", "<e1>", "was", "123", "days", "for", "C0010927#ent", "<e2>", "patients", "and", "171", "days", "for", "patients", "receiving", "dacarbazine-vindesine", "(", "difference", "not", "statistically", "significant", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [8, 9]}}
{"token": ["The", "C2926735#ent", "<e1>", "of", "symptoms", "of", "C0010927#ent", "<e2>", "was", "considerably", "shorter", "in", "the", "two", "substituted", "groups", "in", "the", "heparin", "group", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [6, 7]}}
{"token": ["As", "a", "result", "of", "the", "increased", "neutrophil", "degranulation", "secondary", "to", "chronic", "epithelial", "inflammation", "C0010674#ent", "<e1>", "patients", "with", "chronic", "infections", "Pseudomonas", "aeruginosa", "there", "are", "larger", "amounts", "of", "C0030306#ent", "<e2>", "in", "airway", "secretions", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [26, 27]}}
{"token": ["C0030524#ent", "<e1>", "in", "sheep", "usually", "is", "manifested", "as", "C0013911#ent", "<e2>", "and", "decreased", "wool", "production", "."], "h": {"id": "C0030524", "name": "C0030524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013911", "name": "C0013911#ent", "pos": [8, 9]}}
{"token": ["The", "thrombin/thrombomodulin", "complex", "an", "essential", "role", "in", "regulating", "this", "balance", "because", "it", "generates", "both", "an", "C0003280#ent", "<e1>", "activated", "protein", "C", "and", "an", "antifibrinolytic", "substance", "activated", "TAFI", "(", "C0255161#ent", "<e2>", "also", "known", "as", "plasma", "carboxypeptidase", "B", "carboxypeptidase", "U", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0255161", "name": "C0255161#ent", "pos": [27, 28]}}
{"token": ["A", "sensitive", "and", "specific", "GLC", "method", "is", "described", "to", "determine", "therapeutic", "levels", "of", "C0040219#ent", "<e1>", "and", "its", "two", "main", "metabolites", ",", "C0040219#ent", "<e1>", "and", "bisnortilidine", ",", "in", "plasma", "and", "urine", "."], "h": {"id": "C0040219", "name": "C0040219#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040219", "name": "C0040219#ent", "pos": [13, 14]}}
{"token": ["The", "results", "obtained", "in", "these", "studies", "demonstrate", "a", "dose", "linear", "kinetic", "C0040219#ent", "<e1>", "after", "the", "application", "of", "25", "mg", "to", "100", "mg", "C0040219#ent", "<e1>", "."], "h": {"id": "C0040219", "name": "C0040219#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040219", "name": "C0040219#ent", "pos": [11, 12]}}
{"token": ["In", "our", "population", ",", "2.8", "%", "of", "newborn", "infants", "serologic", "evidence", "of", "C0008149#ent", "<e1>", "1.4", "%", "develop", "either", "C0339959#ent", "<e2>", "conjunctivitis", "."], "h": {"id": "C0008149", "name": "C0008149#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0339959", "name": "C0339959#ent", "pos": [18, 19]}}
{"token": ["C0053792#ent", "<e1>", "well", "tolerated", ";", "the", "most", "common", "side", "effects", "blackening", "of", "C0024421#ent", "<e2>", "and", "stools", "."], "h": {"id": "C0053792", "name": "C0053792#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024421", "name": "C0024421#ent", "pos": [12, 13]}}
{"token": ["After", "1", "to", "2", "min", ",", "DSF", "are", "converted", "to", "C0011522#ent", "<e1>", "identified", "as", "single-stranded", "DNA", "fragments", "C1418773#ent", "<e2>", ")", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418773", "name": "C1418773#ent", "pos": [17, 18]}}
{"token": ["The", "activation", "of", "ASK1", "and", "its", "downstream", "molecule", "C0248813#ent", "<e1>", "was", "observed", "after", "induction", "of", "C1426468#ent", "<e2>", "by", "CD437", "."], "h": {"id": "C0248813", "name": "C0248813#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1426468", "name": "C1426468#ent", "pos": [15, 16]}}
{"token": ["Various", "C3653288#ent", "<e1>", "used", "to", "determine", "to", "what", "extent", "protein", "degradation", "mediated", "by", "C0006784#ent", "<e2>", "and/or", "other", "enzymes", "."], "h": {"id": "C3653288", "name": "C3653288#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [13, 14]}}
{"token": ["In", "both", "of", "these", "simple", "retroviruses", ",", "the", "C0017343#ent", "<e1>", "(", "Env", ")", "protein", "is", "the", "active", "C0029016#ent", "<e2>", "."], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [17, 18]}}
{"token": ["Jaagsiekte", "sheep", "retrovirus", "JSRV", ")", "envelope", "(", "C0017343#ent", "<e1>", ")", "is", "an", "active", "C0029016#ent", "<e2>", "responsible", "for", "neoplastic", "transformation", "animals", "and", "cultured", "cells"], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [13, 14]}}
{"token": ["Characteristic", "features", "of", "PALM", "included", "small", "acinar", "cribriform", "growth", "frequent", "C0024225#ent", "<e1>", "lack", "of", "stromal", "response", "uniform", "round", "nuclei", "with", "prominent", "C1417613#ent", "<e2>", ",", "intraluminal", "blue", "mucin", ",", "and", "prominent", "cell", "borders", "."], "h": {"id": "C0024225", "name": "C0024225#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [21, 22]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "ascertain", "whether", "this", "pattern", "of", "COX-2", "and", "C1415652#ent", "<e1>", "expression", "applies", "also", "to", "other", "C0012634#ent", "<e2>", "induced", "by", "surgical", "procedure"], "h": {"id": "C1415652", "name": "C1415652#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}}
{"token": ["Apart", "from", "the", "knowledge", "concerning", "the", "PMT", "encoding", "C1415652#ent", "<e1>", "very", "little", "is", "known", "about", "the", "genetic", "basis", "C0012634#ent", "<e2>", "caused", "by", "pasteurellas", "associated", "with", "avian", "species", "."], "h": {"id": "C1415652", "name": "C1415652#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["The", "stereoselectivities", "of", "beta-keto", "ester", "reductions", "depended", "both", "on", "the", "identity", "of", "the", "enzyme", "and", "the", "substrate", "structure", "and", "some", "C0028123#ent", "<e1>", "yielded", "both", "L-", "and", "C0001975#ent", "<e2>", "with", "high", "stereoselectivities", "."], "h": {"id": "C0028123", "name": "C0028123#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [26, 27]}}
{"token": ["Neither", "C0013227#ent", "<e1>", "blocked", "LAK", "cell", ",", "nor", "the", "effector", "phase", "either", "NK", "or", "C1538265#ent", "<e2>", "activity", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538265", "name": "C1538265#ent", "pos": [14, 15]}}
{"token": ["The", "C0013227#ent", "<e1>", "did", "not", "significantly", "inhibit", "NK", "or", "C1538265#ent", "<e2>", "cell", "killing", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538265", "name": "C1538265#ent", "pos": [9, 10]}}
{"token": ["We", "then", "used", "fluorescence", "in", "situ", "hybridization", "localize", "E2F1", "to", "human", "chromosome", "20q11", "telomeric", "to", "the", "C2984536#ent", "<e1>", "locus", ",", "a", "C0079429#ent", "<e2>", "whose", "product", "is", "related", "to", "the", "retinoblastoma", "gene", "product", "pRb", ")", "."], "h": {"id": "C2984536", "name": "C2984536#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [21, 22]}}
{"token": ["C3539689#ent", "<e1>", "is", "caused", "by", "a", "deficiency", "of", "C3853627#ent", "<e2>", "hence", "sulfolipids", "are", "accumulated", "in", "various", "patient's", "tissues", "."], "h": {"id": "C3539689", "name": "C3539689#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3853627", "name": "C3853627#ent", "pos": [8, 9]}}
{"token": ["Metachromatic", "Leukodystrophy", "C3539689#ent", "<e1>", ")", "is", "a", "neurodegenerative", "disease", "which", "the", "lysosomal", "enzyme", "Aryl", "sulfatase", "A", "C3853627#ent", "<e2>", ")", "is", "deficient", "."], "h": {"id": "C3539689", "name": "C3539689#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3853627", "name": "C3853627#ent", "pos": [16, 17]}}
{"token": ["The", "possibility", "of", "an", "overuse", "of", "these", "over-the-counter", "drugs", "be", "considered", "in", "the", "differential", "diagnosis", "hypertensive", "emergencies", "especially", "with", "the", "simultaneous", "use", "of", "C3537004#ent", "<e1>", "and", "antihistamine", "medications", ",", "C0304516#ent", "<e2>", "or", "monoamine", "oxidase", "inhibitors"], "h": {"id": "C3537004", "name": "C3537004#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [29, 30]}}
{"token": ["Epidermoid", "tissue", "primary", "and", "even", "some", "secondary", "C0155490#ent", "<e1>", "may", "have", "an", "origin", "in", "the", "C0059036#ent", "<e2>", "."], "h": {"id": "C0155490", "name": "C0155490#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "C1412097#ent", "<e1>", "and", "RNAP", "II", "be", "recruited", "to", "the", "region", "of", "C0087140#ent", "<e2>", "promoter", "."], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [14, 15]}}
{"token": ["The", "mouse", "AtT-20/D16", "-", "16", "anterior", "pituitary", "tumour", "cell", "line", "used", "as", "a", "model", "system", "the", "study", "of", "C1956003#ent", "<e1>", "involvement", "in", "the", "late", "stages", "the", "secretory", "pathway", "adrenocorticotrophin", "(", "C1704793#ent", "<e2>", ")", "secretion", "."], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [30, 31]}}
{"token": ["C1956003#ent", "<e1>", "activity", "was", "not", "influenced", "by", "C1704793#ent", "<e2>", "or", "spermine", "."], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [7, 8]}}
{"token": ["This", "was", "shown", "by", "the", "translocation", "of", "cytochrome", "C", "the", "second", "C3540629#ent", "<e1>", "Smac", ",", "also", "known", "as", "C1427590#ent", "<e2>", ")", "from", "the", "mitochondria", "and", "the", "subsequent", "activation", "of", "caspase-9", "and", "-3", "."], "h": {"id": "C3540629", "name": "C3540629#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1427590", "name": "C1427590#ent", "pos": [18, 19]}}
{"token": ["When", "the", "treatment", "with", "mexiletine", "was", "effective", ",", "C1271398#ent", "<e1>", "increased", "in", "comparison", "with", "that", "when", "the", "C0013227#ent", "<e2>", "was", "ineffective", ",", "or", "vice", "versa", "."], "h": {"id": "C1271398", "name": "C1271398#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "described", "a", "case", "of", "C0038362#ent", "<e1>", "the", "type", "of", "hand", "foot", "and", "mouth", "disease", "mucosal", "and", "C0037274#ent", "<e2>", "an", "adult", "with", "a", "significant", "rise", "of", "neutralizing", "antibodies", "the", "Coxsackie", "B4", "virus"], "h": {"id": "C0038362", "name": "C0038362#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [18, 19]}}
{"token": ["Secondary", "prevention", "transient", "or", "C0007785#ent", "<e1>", "performed", "with", "antiplatelet", "drugs", "e.g.", "aspirin", ",", "ticlopidine", ",", "C0070166#ent", "<e2>", "or", "dipyridamole", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [4, 5]}, "relation": "may_be_prevented_by", "t": {"id": "C0070166", "name": "C0070166#ent", "pos": [15, 16]}}
{"token": ["C3273436#ent", "<e1>", "(", "10", "nmol/L", ")", "stimulated", "MYF", "proliferation", "and", "protein", "synthesis", "C0044602#ent", "<e2>", "and", "p38", "pathways"], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [12, 13]}}
{"token": ["There", "was", "a", "significant", "positive", "correlation", "between", "Bc", "and", "C1412791#ent", "<e1>", ",", "and", "between", "C1419768#ent", "<e2>", "and", "TN", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419768", "name": "C1419768#ent", "pos": [14, 15]}}
{"token": ["When", "C0017860#ent", "<e1>", "were", ",", "however", ",", "added", "repetitively", ",", "C0879590#ent", "<e2>", "also", "produced", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [10, 11]}}
{"token": ["When", "compared", "with", "control", "sera", "IgG", "antibodies", "individual", "histones", "H1", "H2A", ",", "H3", "and", "C1706229#ent", "<e1>", "were", "significantly", "higher", "in", "the", "C0024131#ent", "<e2>", "group", "."], "h": {"id": "C1706229", "name": "C1706229#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024131", "name": "C0024131#ent", "pos": [21, 22]}}
{"token": ["A", "precipitated", "C1332133#ent", "<e1>", "elicited", "with", "C0055236#ent", "<e2>", "in", "rats", "chronically", "dosed", "with", "diazepam", "and", "was", "very", "similar", "to", "the", "C1332133#ent", "<e1>", "precipitated", "by", "Ro15", "-", "1788", "in", "diazepam-dependent", "rats", "."], "h": {"id": "C1332133", "name": "C1332133#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0055236", "name": "C0055236#ent", "pos": [6, 7]}}
{"token": ["Airway", "smooth", "muscle", "ASM", ")", "in", "human", "asthma", "shows", "reduced", "relaxation", "and", "cyclic", "C4285220#ent", "<e1>", "generation", "in", "response", "to", "C0001644#ent", "<e2>"], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [19, 20]}}
{"token": ["Radioimmunologic", "assessment", "of", "cyclic", "C4285220#ent", "<e1>", "tissue", "concentrations", "was", "used", "to", "obtain", "a", "parameter", "for", "C0001644#ent", "<e2>"], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [15, 16]}}
{"token": ["C0524620#ent", "<e1>", "a", "cluster", "of", "C0025517#ent", "<e2>", "hypertension", "--", "is", "not", "a", "new", "disease", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}}
{"token": ["The", "C0524620#ent", "<e1>", "MS", ")", ",", "a", "cluster", "of", "several", "C0025517#ent", "<e2>", "is", "increasingly", "being", "recognized", "as", "a", "risk", "factor", "cardiovascular", "disease"], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [10, 11]}}
{"token": ["C0524620#ent", "<e1>", "a", "cluster", "of", "C0025517#ent", "<e2>", "in", "essence", "greatly", "promotes", "progression", "of", "atherosclerosis", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}}
{"token": ["No", "significant", "correlations", "were", "detected", "between", "C2698419#ent", "<e1>", "immunoreactivity", "and", "amounts", "of", "C1366496#ent", "<e2>", "mRNA", "."], "h": {"id": "C2698419", "name": "C2698419#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366496", "name": "C1366496#ent", "pos": [12, 13]}}
{"token": ["Mutations", "in", "the", "gene", "SLITRK1", "Slit", "and", "C2983389#ent", "<e1>", "have", "been", "reported", "in", "patients", "with", "C0040517#ent", "<e2>", "TD", ")", "."], "h": {"id": "C2983389", "name": "C2983389#ent", "pos": [7, 8]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [15, 16]}}
{"token": ["A", "recent", "report", "suggested", "SLITRK1", "(", "Slit", "and", "C2983389#ent", "<e1>", "as", "a", "candidate", "gene", "for", "C0040517#ent", "<e2>", "TS", ")", "."], "h": {"id": "C2983389", "name": "C2983389#ent", "pos": [8, 9]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [15, 16]}}
{"token": ["We", "have", "investigated", "the", "influence", "of", "3-[1-[3-(amidinothio)propyl]-1H-indoyl-3-yl]-3-(1-methyl-1H-", "indoyl-3-yl", ")", "maleimide", "methane", "sulfonate", "C0084393#ent", "<e1>", ")", ",", "a", "potent", "and", "selective", "inhibitor", "of", "C1259877#ent", "<e2>", "on", "phosphatidylcholine", "secretion", "response", "to", "surfactant", "secretagogues", "in", "rat", "type", "II", "cells"], "h": {"id": "C0084393", "name": "C0084393#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [22, 23]}}
{"token": ["However", ",", "agonist-stimulated", "m3-receptor", "phosphorylation", "was", "not", "inhibited", "by", "C0084393#ent", "<e1>", "indicating", "that", "C1259877#ent", "<e2>", "not", "involved", "in", "agonist-induced", "m3-receptor", "phosphorylation", "."], "h": {"id": "C0084393", "name": "C0084393#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}}
{"token": ["The", "novel", "gene", "ISR1", "encodes", "a", "predicted", "C0033640#ent", "<e1>", "the", "highest", "sequence", "similarity", "to", "mammalian", "C1425569#ent", "<e2>", "in", "the", "kinase", "domain"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [15, 16]}}
{"token": ["Several", "C0033640#ent", "<e1>", "including", "the", "Src", "and", "C1425569#ent", "<e2>", "components", "of", "the", "MAP", "kinase", "system", "are", "also", "bound", "to", "hsp90", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [7, 8]}}
{"token": ["The", "effect", "of", "insulin", "on", "pp39mos", "synthesis", "in", "stage", "IV", "oocytes", "was", "also", "studied", "since", "this", "C0033640#ent", "<e1>", "in", "the", "mitogen-activated", "protein", "kinase", "MAPK", ")", "pathway", "as", "a", "MAPKK", "kinase", "C1425569#ent", "<e2>", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [30, 31]}}
{"token": ["Magnolol", ",", "a", "C0359916#ent", "<e1>", "constituent", "of", "magnolia", "bark", "is", "a", "known", "central", "nervous", "system", "C0003289#ent", "<e2>", "."], "h": {"id": "C0359916", "name": "C0359916#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "whether", "C0877017#ent", "<e1>", "ECS", ")", "in", "rats", "stimulates", "cellular", "proliferation", "the", "C1418482#ent", "<e2>", "immediately", "and", "four", "weeks", "after", "the", "treatments", "."], "h": {"id": "C0877017", "name": "C0877017#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [13, 14]}}
{"token": ["This", "includes", "the", "observation", "that", "agents", "that", "perturb", "C0016964#ent", "<e1>", "interrupt", "epithelial", "cell", "adhesion", "cause", "C4283936#ent", "<e2>", "release", "from", "the", "cell", "layer"], "h": {"id": "C0016964", "name": "C0016964#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283936", "name": "C4283936#ent", "pos": [15, 16]}}
{"token": ["Trypsin", "and", "C0031691#ent", "<e1>", "were", "used", "as", "internal", "calibrators", "intact", "protein", "analysis", "a", "C0030956#ent", "<e2>", "EYEATLEECCAK", "was", "used", "as", "internal", "calibrator", "fragment", "analysis"], "h": {"id": "C0031691", "name": "C0031691#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [13, 14]}}
{"token": ["In", "resting", "cells", "C0812228#ent", "<e1>", "is", "found", "in", "the", "cytosol", "in", "complex", "with", "Rho", "GDP", "dissociation", "inhibitor", "C1415038#ent", "<e2>", ")", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415038", "name": "C1415038#ent", "pos": [17, 18]}}
{"token": ["Integrins", "increase", "membrane", "affinity", "C0812228#ent", "<e1>", ",", "leading", "to", "C1415038#ent", "<e2>", "dissociation", "and", "effector", "coupling", "locally", ",", "in", "the", "vicinity", "of", "activated/bound", "integrins", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415038", "name": "C1415038#ent", "pos": [9, 10]}}
{"token": ["In", "a", "double-blind", "trial", "patients", "with", "C0029408#ent", "<e1>", "were", "treated", "for", "relief", "of", "pain", "with", "C0022635#ent", "<e2>", "or", "with", "the", "N-methyl-d-glucamine", "salt", "of", "indomethacin", ",", "both", "drugs", "being", "administered", "i.m", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0022635", "name": "C0022635#ent", "pos": [15, 16]}}
{"token": ["It", "is", "usually", "hormonally", "inactive", "but", "there", "were", "several", "cases", "in", "which", "adrenal", "myelolipoma", "with", "various", "endocrine", "disorders", "as", "C0010481#ent", "<e1>", "Conn's", "syndrome", "Addison's", "disease", "hirsutism", ",", "hermaphroditism", ",", "inborn", "deficiencies", "17-", "and", "C0038304#ent", "<e2>", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0038304", "name": "C0038304#ent", "pos": [33, 34]}}
{"token": ["In", "conclusion", ",", "BK", "has", "mitogenic", "actions", "in", "cultured", "human", "epithelial", "breast", "cells", "the", "activation", "of", "PKC-delta", "through", "C1333340#ent", "<e1>", "in", "concert", "with", "ERK", "and", "C1705325#ent", "<e2>", "induce", "cell", "proliferation"], "h": {"id": "C1333340", "name": "C1333340#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705325", "name": "C1705325#ent", "pos": [25, 26]}}
{"token": ["Some", "of", "the", "resulting", "C3539945#ent", "<e1>", "showed", "local", "anesthetic", "properties", "than", "those", "of", "C0358490#ent", "<e2>"], "h": {"id": "C3539945", "name": "C3539945#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0358490", "name": "C0358490#ent", "pos": [13, 14]}}
{"token": ["We", "have", "recently", "characterized", "additional", "EWS-WT1", "translocations", "that", "involve", "the", "juxtaposition", "of", "C0808901#ent", "<e1>", "exons", "7", "or", "8", "to", "WT1", "exon", "8", "and", "an", "C3274610#ent", "<e2>", "lacks", "C0808901#ent", "<e1>", "exon", "6"], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [12, 13]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274610", "name": "C3274610#ent", "pos": [24, 25]}}
{"token": ["Such", "proteins", ",", "including", "C0059036#ent", "<e1>", "eEF1A", ")", ",", "are", "frequently", "reactivated", "by", "C0120465#ent", "<e2>", "GEFs", ")", "."], "h": {"id": "C0059036", "name": "C0059036#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [13, 14]}}
{"token": ["C0059036#ent", "<e1>", "delta", "provides", "the", "C0120465#ent", "<e2>", "EF-1", "alpha", "elongation", "step", "of", "protein", "synthesis"], "h": {"id": "C0059036", "name": "C0059036#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [5, 6]}}
{"token": ["They", "included", "four", "proteases", "(", "mouse", "C0220300#ent", "<e1>", "granzyme", "B", "pepsinogen", "F", "serine", "protease", "1", "and", "two", "metabolic", "enzymes", "C0001414#ent", "<e2>", "fructose1,6-bisphosphatase", ")", "."], "h": {"id": "C0220300", "name": "C0220300#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001414", "name": "C0001414#ent", "pos": [19, 20]}}
{"token": ["C3540588#ent", "<e1>", "partially", "colocalized", "with", "C1416638#ent", "<e2>", "NUDEL", ",", "LIS1", ",", "and", "14", "-", "3", "-", "3epsilon", "in", "the", "growth", "cones"], "h": {"id": "C3540588", "name": "C3540588#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416638", "name": "C1416638#ent", "pos": [5, 6]}}
{"token": ["Low", "density", "lipoprotein", "receptor", "LDLR", ")", "C0678941#ent", "<e1>", "familial", "hypercholesterolemia", "is", "associated", "with", "elevated", "risk", "of", "C0151744#ent", "<e2>"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [16, 17]}}
{"token": ["In", "the", "following", "report", "we", "describe", "a", "unique", "case", "of", "spontaneous", "rupture", "the", "sigmoid", "secondary", "to", "spontaneous", "recurrent", "C0032326#ent", "<e1>", "a", "young", "patient", "with", "undiagnosed", "C0024796#ent", "<e2>"], "h": {"id": "C0032326", "name": "C0032326#ent", "pos": [18, 19]}, "relation": "manifestation_of", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [25, 26]}}
{"token": ["A", "case", "of", "C0032326#ent", "<e1>", "the", "patient", "with", "C0024796#ent", "<e2>", "reported", "13-year-old", "male", "was", "admitted", "to", "our", "hospital", "with", "diagnosis", "of", "left", "pneumothorax"], "h": {"id": "C0032326", "name": "C0032326#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [8, 9]}}
{"token": ["A", "current", "model", "suggests", "that", "the", "intercalative", "and", "minor", "groove", "binding", "components", "of", "C0005117#ent", "<e1>", "and", "related", "compounds", "are", "important", "for", "C1458146#ent", "<e2>", "II", "inhibition", "."], "h": {"id": "C0005117", "name": "C0005117#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [21, 22]}}
{"token": ["C0005117#ent", "<e1>", "are", "a", "new", "class", "of", "organic", "cations", "are", "dual", "poisons", "C1458146#ent", "<e2>", "II", "."], "h": {"id": "C0005117", "name": "C0005117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [12, 13]}}
{"token": ["The", "E4", "isoform", "of", "apolipoprotein", "E", "C1412481#ent", "<e1>", ")", "has", "been", "associated", "with", "clearance", "of", "C1705543#ent", "<e2>", "under", "in", "vitro", "conditions", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [15, 16]}}
{"token": ["Paroxetine", "and", ",", "to", "a", "lesser", "degree", ",", "fluoxetine", "and", "C0068987#ent", "<e1>", "are", "potent", "inhibitors", "of", "CYP2D6", "and", "C0085228#ent", "<e2>", "of", "CYP1A2", "and", "CYP2C19", "."], "h": {"id": "C0068987", "name": "C0068987#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085228", "name": "C0085228#ent", "pos": [18, 19]}}
{"token": ["Dihydralazine", ",", "sold", "under", "the", "name", "of", "Nepressol", ",", "is", "the", "derivative", "of", "the", "C0020223#ent", "<e1>", "used", "in", "France", "for", "the", "treatment", "of", "severe", "C0018801#ent", "<e2>"], "h": {"id": "C0020223", "name": "C0020223#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [24, 25]}}
{"token": ["The", "C0020223#ent", "<e1>", "act", "in", "C0018801#ent", "<e2>", "decreasing", "systemic", "arterial", "resistance", "increasing", "cardiac", "output", "causing", "tachycardia", "or", "increasing", "myocardial", "contractility", "normal", "or", "hypotensive", "subjects", "."], "h": {"id": "C0020223", "name": "C0020223#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [5, 6]}}
{"token": ["Ectopic", "expression", "of", "C1335238#ent", "<e1>", "and", "RXRalpha", "repressed", "C1854336#ent", "<e2>", "-", "323", "transactivation", "with", "S6K1", "inhibition", ",", "which", "was", "abrogated", "by", "CA-S6K1", "transfection", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1854336", "name": "C1854336#ent", "pos": [8, 9]}}
{"token": ["The", "nonselective", "muscarinic", "receptor", "agonists", "muscarine", "and", "carbachol", "both", "stimulated", "C1424659#ent", "<e1>", "release", "from", "perifused", "frog", "C0027721#ent", "<e2>", ",", "whereas", "the", "M1-selective", "muscarinic", "agonist", "McN-A-343", "was", "virtually", "devoid", "of", "effect", "."], "h": {"id": "C1424659", "name": "C1424659#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [16, 17]}}
{"token": ["C1412420#ent", "<e1>", "insulin-like", "growth", "factor-binding", "protein", "2", "overexpressed", "in", "cancer", "but", "not", "in", "C0149521#ent", "<e2>", "making", "them", "promising", "biomarker", "candidates", "for", "pancreatic", "cancer"], "h": {"id": "C1412420", "name": "C1412420#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [13, 14]}}
{"token": ["Recent", "concepts", "in", "aetiopathogenesis", "include", "the", "role", "of", "C0037688#ent", "<e1>", "excess", "and", "myoinositol", "depletion", "in", "causing", "deficient", "C1412628#ent", "<e2>", "."], "h": {"id": "C0037688", "name": "C0037688#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412628", "name": "C1412628#ent", "pos": [17, 18]}}
{"token": ["Biochemical", "findings", "compatible", "with", "C0004775#ent", "<e1>", "occur", "together", "with", "evidence", "of", "generalized", "proximal", "renal", "tubular", "dysfunction", "C0015624#ent", "<e2>", "in", "nephropathic", "cystinosis"], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "case", "2", "transient", "features", "of", "C0004775#ent", "<e1>", "preceded", "the", "manifestations", "of", "C0015624#ent", "<e2>"], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [14, 15]}}
{"token": ["After", "administration", ",", "EZE", "is", "extensively", "metabolized", "in", "liver", "and", "intestine", "to", "its", "phenolic", "glucuronide", "form", "EZE-G", ")", "by", "C0537026#ent", "<e1>", "UGTs", ")", ",", "among", "which", "C1567723#ent", "<e2>", "and", "1A3", "exhibit", "highest", "activity", "."], "h": {"id": "C0537026", "name": "C0537026#ent", "pos": [19, 20]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1567723", "name": "C1567723#ent", "pos": [26, 27]}}
{"token": ["The", "effects", "of", "cardioselective", "beta-blocker", "C0025859#ent", "<e1>", ",", "were", "evaluated", "under", "double-blind", "conditions", "eighteen", "patients", "with", "C0002962#ent", "<e2>"], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [16, 17]}}
{"token": ["We", "present", "an", "unusual", "case", "of", "inguinal", "keratotic", "basal", "cell", "carcinoma", "C0017547#ent", "<e1>", "solitary", "trichoepithelioma", "a", "56-year-old", "woman", "with", "a", "finger-like", "tumor", "20", "years", "C2926735#ent", "<e2>", "."], "h": {"id": "C0017547", "name": "C0017547#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [24, 25]}}
{"token": ["Intracellular", "injection", "of", "tetraethylammonium", "chloride", "TEA", ")", "into", "a", "C0017547#ent", "<e1>", "axon", "of", "the", "squid", "prolongs", "the", "C2926735#ent", "<e2>", "of", "the", "action", "potential", "without", "changing", "the", "resting", "potential", "(", "Fig.", "3", ")", "."], "h": {"id": "C0017547", "name": "C0017547#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [17, 18]}}
{"token": ["The", "inactivation", "of", "C0017547#ent", "<e1>", "only", "causes", "behavioural", "effects", "nociceptive", "tests", "a", "long", "enough", "C2926735#ent", "<e2>", "to", "activate", "the", "system", "(", "i.e.", "the", "formalin", "test", "not", "the", "tail", "flick", "test", ")", "."], "h": {"id": "C0017547", "name": "C0017547#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [14, 15]}}
{"token": ["C0073629#ent", "<e1>", "did", "not", "reduce", "the", "incidence", "of", "C0085083#ent", "<e2>", "degree", "III", "at", "all", "(", "OR", "1.08", ";", "95", "%", "CI", "0.27", "-", "4.38", ")", "."], "h": {"id": "C0073629", "name": "C0073629#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0085083", "name": "C0085083#ent", "pos": [8, 9]}}
{"token": ["C1335047#ent", "<e1>", "negative", "for", "ER", "and", "C1366500#ent", "<e2>", "in", "all", "but", "one", "case", "in", "which", "weak", "staining", "for", "C1366500#ent", "<e2>", "was", "present", "adjacent", "to", "a", "follicular", "adenoma"], "h": {"id": "C1335047", "name": "C1335047#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366500", "name": "C1366500#ent", "pos": [6, 7]}}
{"token": ["C3896756#ent", "<e1>", "has", "been", "shown", "to", "be", "C3889446#ent", "<e2>", "in", "multiple", "tumor", "types", ",", "thus", "attracting", "high", "interest", "to", "its", "potential", "upstream", "regulators"], "h": {"id": "C3896756", "name": "C3896756#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [7, 8]}}
{"token": ["Conversely", ",", "expression", "of", "a", "C1452441#ent", "<e1>", "form", "of", "C0080279#ent", "<e2>", "or", "reconstitution", "of", "abl-/-", "arg-/-", "cells", "with", "wild-type", "C0080279#ent", "<e2>", "prevents", "Crk-CAS", "coupling", "and", "inhibits", "cell", "migration"], "h": {"id": "C1452441", "name": "C1452441#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [9, 10]}}
{"token": ["Noteworthy", "among", "the", "various", "pulmonary", "entities", "to", "IBD", "are", "chronic", "bronchitis", "bronchiectasis", ",", "though", "reports", "of", "bronchiolitis", ",", "obliterants", "bronchiolitis", "with", "organizing", "C0032285#ent", "<e1>", "and", "other", "C1881236#ent", "<e2>", "also", "been", "published", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1881236", "name": "C1881236#ent", "pos": [26, 27]}}
{"token": ["The", "five", "main", "indications", "are", "tumor", ",", "hemoptysis", ",", "infection", "or", "C0032285#ent", "<e1>", ",", "drainage", "of", "secretions", "and", "suspected", "C1881236#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1881236", "name": "C1881236#ent", "pos": [19, 20]}}
{"token": ["Examples", "of", "cytoprotective", "agents", "dexrazoxane", "(", "ICRF-187", ")", ",", "protecting", "against", "doxorubicin", "cardiotoxicity", ",", "and", "C3537278#ent", "<e1>", "protecting", "against", "the", "myelosuppression", "of", "C1171558#ent", "<e2>", "and", "alkylating", "agents"], "h": {"id": "C3537278", "name": "C3537278#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1171558", "name": "C1171558#ent", "pos": [22, 23]}}
{"token": ["The", "C0003289#ent", "<e1>", "effects", "could", "be", "antagonized", "by", "(+)-amphetamine", ",", "C0011685#ent", "<e2>", ",", "dibutyryl", "cyclic", "3'5'-adenosine", "monophosphate", "and", "caffeine.3", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [10, 11]}}
{"token": ["The", "C1564140#ent", "<e1>", "three", "classes", "of", "effect", "on", "the", "activation", "of", "C0027120#ent", "<e2>", "CaM-dependent", "protein", "kinase", "IIalpha", "and", "CaM-dependent", "protein", "kinase", "IV"], "h": {"id": "C1564140", "name": "C1564140#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027120", "name": "C0027120#ent", "pos": [11, 12]}}
{"token": ["In", "a", "high", "percentage", "of", "cases", ",", "severe", "C0243026#ent", "<e1>", "is", "accompanied", "by", "acute", "respiratory", "failure", "in", "which", "C0427055#ent", "<e2>", "of", "the", "respiratory", "muscles", "an", "important", "role", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [18, 19]}}
{"token": ["C0243026#ent", "<e1>", ",", "excessive", "inflammation", ",", "multiple", "organ", "failure", "C0427055#ent", "<e2>", "prolong", "the", "need", "for", "intensive", "care", "critically", "ill", "patients", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [9, 10]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "assess", "the", "efficacy", "and", "safety", "of", "Gabapentin", "as", "the", "sole", "C0728960#ent", "<e1>", "in", "patients", "with", "C0078911#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0078911", "name": "C0078911#ent", "pos": [22, 23]}}
{"token": ["We", "examined", "the", "effects", "of", "C0060197#ent", "<e1>", "on", "two", "prostate", "carcinoma", "cell", "lines", "LNCaP", "(", "an", "C1857728#ent", "<e2>", ",", "p53(+/+", ")", "cell", "line", "and", "PC-3", "(", "an", "androgen-insensitive", ",", "p53(-/-", ")", "cell", "line", ")", "."], "h": {"id": "C0060197", "name": "C0060197#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1857728", "name": "C1857728#ent", "pos": [16, 17]}}
{"token": ["Glomerulonephritis", "(", "n", "=", "37", ")", "and", "C3495566#ent", "<e1>", "n", "=", "26", ")", "were", "the", "most", "frequent", "C0022658#ent", "<e2>", "identified", "."], "h": {"id": "C3495566", "name": "C3495566#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [17, 18]}}
{"token": ["In", "patients", "with", "moderate", ",", "C0020474#ent", "<e1>", "ischemic", "heart", "disease", "treatment", "with", "C3536880#ent", "<e2>", "limited", "by", "the", "side", "effects", "the", "drug", "."], "h": {"id": "C0020474", "name": "C0020474#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536880", "name": "C3536880#ent", "pos": [12, 13]}}
{"token": ["Short-term", "voluntary", "run", "training", "increased", "C1334332#ent", "<e1>", "mRNA", "concentration", "and", "C1334332#ent", "<e1>", "immunoreactive", "mass", "about", "threefold", "in", "C0043153#ent", "<e1>", "the", "rat", "hindlimb", "(", "all", "P", "<", "0.01", ")", "."], "h": {"id": "C1334332", "name": "C1334332#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0043153", "name": "C0043153#ent", "pos": [17, 18]}}
{"token": ["In", "approximately", "300", "to", "500", "C0848332#ent", "<e1>", "visualized", "on", "each", "gel", ",", "various", "exoproteins", "and", "C1313497#ent", "<e2>", "identified", "and", "their", "sites", "on", "the", "gels", "confirmed", "for", "construction", "of", "a", "reference", "map"], "h": {"id": "C0848332", "name": "C0848332#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1313497", "name": "C1313497#ent", "pos": [15, 16]}}
{"token": ["Onset", "of", "the", "p107-dependent", "senescence", "was", "temporally", "associated", "with", "stabilization", "of", "the", "C1511576#ent", "<e1>", "p27", "and", "decreases", "in", "c-myc", "and", "C3540489#ent", "<e2>", "expression", "."], "h": {"id": "C1511576", "name": "C1511576#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540489", "name": "C3540489#ent", "pos": [20, 21]}}
{"token": ["The", "patient", "presented", "with", "severe", "C1535939#ent", "<e1>", "and", "developed", "renal", "failure", "disseminated", "intravascular", "coagulation", "C0015625#ent", "<e2>", "which", "recurred", "after", "antibiotics", "were", "discontinued", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [14, 15]}}
{"token": ["The", "second", "patient", "had", "C1535939#ent", "<e1>", "with", "cavitation", "during", "C0015625#ent", "<e2>", "after", "chemotherapy", "for", "acute", "monocytic", "leukemia"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [9, 10]}}
{"token": ["This", "activation", "as", "determined", "by", "the", "TAP", "increase", "was", "significantly", "reduced", "by", "the", "serine", "protease", "C0060891#ent", "<e1>", "but", "not", "by", "the", "cathepsin", "B", "inhibitors", "C0058882#ent", "<e2>", "and", "NCO-700", "."], "h": {"id": "C0060891", "name": "C0060891#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0058882", "name": "C0058882#ent", "pos": [24, 25]}}
{"token": ["Promastigotes", "of", "multiple", "Leishmania", "species", "rapidly", "degrade", "C1706331#ent", "<e1>", "by", "using", "surface-localized", "and", "secreted", "metalloprotease", "C0061676#ent", "<e2>", ")", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061676", "name": "C0061676#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "five", "laboratories", "tested", "10", "candidate", "C0245636#ent", "<e1>", "strains", "20", "times", "each", "against", "three", "antifungal", "agents", "amphotericin", "B", "C0016277#ent", "<e2>", ",", "and", "5-fluorocytosine", "."], "h": {"id": "C0245636", "name": "C0245636#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [22, 23]}}
{"token": ["These", "two", "strains", "are", "recommended", "for", "C0245636#ent", "<e1>", "testing", "of", "amphotericin", "B", "C0016277#ent", "<e2>", ",", "and", "5FC", "."], "h": {"id": "C0245636", "name": "C0245636#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [12, 13]}}
{"token": ["The", "management", "of", "patients", "diagnosed", "with", "C0040460#ent", "<e1>", "AO", ")", "is", "a", "challenging", "C0310298#ent", "<e2>", "."], "h": {"id": "C0040460", "name": "C0040460#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [13, 14]}}
{"token": ["The", "C0936059#ent", "<e1>", "field", "illustrates", "how", "C1512076#ent", "<e2>", "may", "be", "used", "as", "a", "critical", "tool", "for", "the", "study", "of", "cell", "biology"], "h": {"id": "C0936059", "name": "C0936059#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1512076", "name": "C1512076#ent", "pos": [6, 7]}}
{"token": ["The", "results", "showed", "that", "at", "least", "three", "Ts", "must", "exist", "at", "the", "5", "'", "C3148500#ent", "<e1>", "for", "the", "high", "transcriptional", "activity", "the", "C1705442#ent", "<e2>", "."], "h": {"id": "C3148500", "name": "C3148500#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705442", "name": "C1705442#ent", "pos": [22, 23]}}
{"token": ["Exposure", "to", "C0282210#ent", "<e1>", "or", "PGE2", "also", "caused", "an", "attenuated", "cyclic", "AMP", "to", "C0205911#ent", "<e2>", "(", "PGI2", ")", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [13, 14]}}
{"token": ["In", "clinical", "studies", "over", "50", "%", "of", "ED", "patients", "receiving", "C0529793#ent", "<e1>", "got", "a", "fully", "C0026837#ent", "<e2>", "grade", "4", "erection", "."], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [15, 16]}}
{"token": ["In", "part", "I", ",", "the", "effect", "of", "a", "single", "dose", "25", "mg", "or", "50", "mg", ")", "of", "C0529793#ent", "<e1>", "or", "placebo", "on", "C0026837#ent", "<e2>", "assessed", "by", "penile", "plethysmography", "visual", "sexual", "stimulation"], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [22, 23]}}
{"token": ["To", "study", "the", "role", "of", "C0059239#ent", "<e1>", "FAK", ")", "and", "its", "association", "with", "Src", "in", "C1442521#ent", "<e2>", "cell", "signaling", "cholangiocarcinoma", "progression", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [15, 16]}}
{"token": ["To", "study", "the", "role", "of", "focal", "adhesion", "kinase", "C0059239#ent", "<e1>", ")", "and", "its", "association", "with", "Src", "in", "C1442521#ent", "<e2>", "cell", "signaling", "cholangiocarcinoma", "progression", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [17, 18]}}
{"token": ["We", "determined", "the", "incidence", "of", "hypercalciuria", "(", "HC", ")", "and", "its", "association", "with", "nephrocalcinosis", "and", "C0022650#ent", "<e1>", "in", "18", "consecutive", "patients", "with", "C0004903#ent", "<e2>", "BWS", ")", "."], "h": {"id": "C0022650", "name": "C0022650#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0004903", "name": "C0004903#ent", "pos": [22, 23]}}
{"token": ["This", "assumption", "was", "supported", "by", "test", "results", "with", "C0985528#ent", "<e1>", "(", "DES", ")", "(", "non-steroidal", "estrogen", "on", "the", "Dunning", "R3327", "C1418943#ent", "<e2>", "of", "the", "rat", "relapsed", "after", "orchiectomy", "."], "h": {"id": "C0985528", "name": "C0985528#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [20, 21]}}
{"token": ["Similar", "analyses", "of", "C0030016#ent", "<e1>", "that", "regulate", "the", "concentrations", "of", "steroids", ",", "retinoids", "and", "C0356622#ent", "<e2>", "reveal", "strong", "sequence", "similarity", "enzymes", "in", "plants", ",", "insects", ",", "fungi", ",", "and", "bacteria", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [14, 15]}}
{"token": ["Percutaneous", "transluminal", "angioplasty", "C1427472#ent", "<e1>", ")", "of", "the", "superior", "mesenteric", "artery", "C0026847#ent", "<e2>", ")", "and", "coeliac", "axis", "CA", ")", "is", "a", "well", "recognized", "form", "of", "treatment", "for", "patients", "with", "chronic", "intestinal", "ischaemia", "carries", "a", "low", "morbidity", "and", "mortality", "."], "h": {"id": "C1427472", "name": "C1427472#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [11, 12]}}
{"token": ["Percutaneous", "transluminal", "angioplasty", "C1427472#ent", "<e1>", ")", "of", "the", "superior", "mesenteric", "artery", "C0026847#ent", "<e2>", ")", "was", "performed", "in", "a", "65-year-old", "man", "with", "clinical", "and", "radiographic", "evidence", "of", "abdominal", "angina"], "h": {"id": "C1427472", "name": "C1427472#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [11, 12]}}
{"token": ["Percutaneous", "transluminal", "angioplasty", "C1427472#ent", "<e1>", ")", "of", "the", "occluded", "native", "origin", "of", "the", "C0026847#ent", "<e2>", "was", "successful", "."], "h": {"id": "C1427472", "name": "C1427472#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [13, 14]}}
{"token": ["Dent's", "disease", "a", "rare", "C0151747#ent", "<e1>", "by", "low-molecular", "weight", "proteinuria", "hypercalciuria", ",", "nephrocalcinosis", ",", "nephrolithiasis", ",", "C1527410#ent", "<e2>", "and", "eventual", "renal", "failure"], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1527410", "name": "C1527410#ent", "pos": [16, 17]}}
{"token": ["The", "oculo-cerebral-renal", "syndrome", "Lowe", "is", "an", "X-linked", "recessive", "disorder", "by", "severe", "mental", "retardation", "congenital", "cataracts", "C0151747#ent", "<e1>", "growth", "retardation", "hypotonia", ",", "glaucoma", ",", "and", "C1527410#ent", "<e2>", "."], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1527410", "name": "C1527410#ent", "pos": [24, 25]}}
{"token": ["The", "C0020538#ent", "<e1>", "independent", "of", "salt", "uptake", "can", "not", "be", "controlled", "by", "C0037982#ent", "<e2>", "but", "is", "inhibited", "by", "a", "GC", "antagonist", "such", "as", "RU486", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [12, 13]}}
{"token": ["The", "C0162429#ent", "<e1>", "mice", "consistently", "had", "higher", "C0304604#ent", "<e2>", "levels", "than", "controls", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0304604", "name": "C0304604#ent", "pos": [7, 8]}}
{"token": ["The", "first", "evaluated", "the", "affinities", "of", "the", "C2987634#ent", "<e1>", "(", "including", "acetylcholine", "and", "C0600175#ent", "<e2>", ")", "for", "the", "recognition", "site", "allowing", "the", "C2987634#ent", "<e1>", "to", "compete", "for", "that", "site", "with", "125I-alpha-bungarotoxin", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600175", "name": "C0600175#ent", "pos": [13, 14]}}
{"token": ["This", "neurotransmitter", "C2987634#ent", "<e1>", "effect", "is", ",", "however", ",", "reversible", "as", "removal", "of", "C0600175#ent", "<e2>", "by", "dialysis", "restores", "the", "quenching", "effectiveness", "to", "that", "of", "resting", "nonliganded", "membranes", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0600175", "name": "C0600175#ent", "pos": [13, 14]}}
{"token": ["C1421511#ent", "<e1>", "was", "most", "frequently", "detected", "in", "RA", "synovium", ",", "and", "C1705728#ent", "<e2>", ",", "FRP2", ",", "and", "FRP4", "in", "OA", "synovium"], "h": {"id": "C1421511", "name": "C1421511#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705728", "name": "C1705728#ent", "pos": [11, 12]}}
{"token": ["Results", "from", "chromatin", "immunoprecipitation", "assays", "that", "dominant", "negative", "C1335843#ent", "<e1>", "significantly", "attenuated", "the", "ability", "of", "C1422572#ent", "<e2>", "to", "increase", "SRF", "binding", "to", "the", "promoters", "of", "smooth", "muscle-specific", "genes", "but", "not", "early", "response", "genes", "."], "h": {"id": "C1335843", "name": "C1335843#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422572", "name": "C1422572#ent", "pos": [15, 16]}}
{"token": ["Reintroduction", "of", "C1335843#ent", "<e1>", "or", "Brm", "into", "SW13", "cells", "restored", "their", "responsiveness", "to", "C1422572#ent", "<e2>", "."], "h": {"id": "C1335843", "name": "C1335843#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422572", "name": "C1422572#ent", "pos": [13, 14]}}
{"token": ["Corticosteroids", ",", "potent", "C0003211#ent", "<e1>", "and", "allopurinol", "--", "a", "C1421531#ent", "<e2>", "inhibitor", "that", "blocks", "the", "generation", "of", "oxygen-derived", "free", "radicals", "may", "be", "potentially", "effective", "in", "preventing", "post-ERCP", "pancreatitis", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [9, 10]}}
{"token": ["C0086376#ent", "<e1>", "with", "N-terminal", "pyroglutamic", "acid", "enzymatically", "deblocked", "by", "in", "situ", "C0034307#ent", "<e2>", "and", "N-acetylated", "proteins", "were", "also", "enzymatically", "deblocked", "with", "acylamino", "acid-releasing", "enzyme", "AARE", ")", "after", "on-membrane", "digestion", "with", "trypsin", "to", "generate", "the", "N-terminal", "peptide", "fragment"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034307", "name": "C0034307#ent", "pos": [11, 12]}}
{"token": ["S1P2R", "activation", "in", "ECs", "induced", "C1565860#ent", "<e1>", "expression", "and", "suppressed", "the", "expression", "of", "C1328053#ent", "<e2>", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [13, 14]}}
{"token": ["These", "studies", "directly", "support", "C1417838#ent", "<e1>", "participating", "in", "the", "regulation", "of", "C3540050#ent", "<e2>", "in", "vivo"], "h": {"id": "C1417838", "name": "C1417838#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540050", "name": "C3540050#ent", "pos": [11, 12]}}
{"token": ["C1136254#ent", "<e1>", "concentration", "measurements", "from", "the", "bronchial", "mucosa", "ELF", ",", "and", "C3813124#ent", "<e2>", "may", "be", "better", "predictors", "of", "successful", "antimicrobial", "therapy", "sputum", "samples"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [11, 12]}}
{"token": ["Our", "data", "indicate", "that", "the", "release", "of", "C1136254#ent", "<e1>", "not", "prevent", "chlamydial", "infection", "replication", "in", "C3813124#ent", "<e2>", ",", "but", "may", "be", "involved", "in", "amplification", "of", "the", "local", "inflammatory", "response", "C.", "pneumoniae", "pneumonia"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [15, 16]}}
{"token": ["The", "ability", "of", "the", "tested", "C1136254#ent", "<e1>", "enter", "human", "C3813124#ent", "<e2>", "correlates", "well", "with", "the", "efficacy", "of", "these", "drugs", "in", "treatment", "of", "certain", "intracellular", "pulmonary", "infections"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [9, 10]}}
{"token": ["We", "measured", "the", "C1136254#ent", "<e1>", "MCP-1", "and", "MCP-2", "in", "rabbit", "alveolar", "macrophages", "C3813124#ent", "<e2>", ")", ",", "comparing", "rabbits", "pretreated", "with", "complete", "Freund", "adjuvant", "untreated", "control", "animals"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [12, 13]}}
{"token": ["Several", "C0341703#ent", "<e1>", ",", "including", "a", "homolog", "of", "C1705079#ent", "<e2>", ",", "surround", "A.", "tumefaciens", "rnd", ",", "but", "none", "of", "these", "genes", "exerted", "a", "detectable", "effect", "on", "the", "expression", "of", "the", "tra", "reporter"], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705079", "name": "C1705079#ent", "pos": [8, 9]}}
{"token": ["Therefore", ",", "by", "comparing", "HLA", "antigen", "frequencies", "between", "first-degree", "relatives", "we", "sought", "to", "identify", "C0599797#ent", "<e1>", "influence", "progression", "to", "C3273872#ent", "<e2>", "."], "h": {"id": "C0599797", "name": "C0599797#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "C1419336#ent", "<e1>", "could", "be", "an", "amino", "acid-specific", "elongation", "factor", ",", "replacing", "C1705442#ent", "<e2>", "in", "a", "special", "translational", "step", "."], "h": {"id": "C1419336", "name": "C1419336#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705442", "name": "C1705442#ent", "pos": [13, 14]}}
{"token": ["C1419336#ent", "<e1>", ",", "thus", ",", "is", "a", "translation", "factor", "homologous", "to", "C1705442#ent", "<e2>", "hooked", "up", "to", "the", "mRNA", "with", "its", "C-terminal", "end"], "h": {"id": "C1419336", "name": "C1419336#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705442", "name": "C1705442#ent", "pos": [11, 12]}}
{"token": ["The", "inhibition", "caused", "by", "C1420357#ent", "<e1>", "could", "be", "reversed", "by", "PI", ",", "PS", ",", "and", "C0028928#ent", "<e2>", "not", "by", "PC", "and", "sphingomyelin", "."], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "and", "modes", "of", "action", "of", "certain", "lipid", "second", "messengers", "protein", "kinase", "C", "regulators", "such", "as", "C1420357#ent", "<e1>", ",", "lysophosphatidylcholine", "(", "lyso-PC", ")", ",", "and", "C0028928#ent", "<e2>", "on", "Na", ",", "K-ATPase", "and", "sodium", "pump", "examined", "."], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [26, 27]}}
{"token": ["The", "chain", "base", "predominantly", "C1420357#ent", "<e1>", "and", "the", "fatty", "acids", "were", "mainly", "stearate", "and", "C0028928#ent", "<e2>", "."], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [14, 15]}}
{"token": ["We", "found", "that", "8-bromoadenosine-3',5'-cyclic-monophosphate", "(8Br-cAMP)-induced", "the", "activation", "of", "C1370600#ent", "<e1>", "and", "mitogen-activated", "protein", "kinase", "MEK", ")", ",", "but", "inhibited", "B-Raf", "kinase", "a", "C0010531#ent", "<e2>", "mechanism", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [22, 23]}}
{"token": ["Trapidil", "suppresses", "platelet-derived", "growth", "factor", "vascular", "smooth", "muscle", "cell", "VSMC", ")", "proliferation", "by", "inhibiting", "Raf-1/extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e1>", ")", "via", "cAMP/protein", "kinase", "A", "(", "C0010531#ent", "<e2>", ")", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [25, 26]}}
{"token": ["This", "would", "indicate", "activation", "of", "a", "C0079429#ent", "<e1>", "in", "haploid", "germ", "cells", "encoding", "a", "regulatory", "subunit", "C0033639#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033639", "name": "C0033639#ent", "pos": [16, 17]}}
{"token": ["We", "have", "cloned", "a", "full-length", "cDNA", "coding", "human", "C0001942#ent", "<e1>", "ADH", ";", "alcohol", ":", "NAD+", "oxidoreductase", "C1312457#ent", "<e2>", "from", "a", "human", "liver", "cDNA", "library", "constructed", "in", "phage", "lambda", "gt11"], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1312457", "name": "C1312457#ent", "pos": [16, 17]}}
{"token": ["Using", "C0311727#ent", "<e1>", "a", "heat-sensitive", "reporter", "protein", ",", "we", "demonstrate", "that", "C1333928#ent", "<e2>", "expression", "in", "HspB1-deficient", "fibroblasts", "enhances", "protein", "refolding", "heat", "shock"], "h": {"id": "C0311727", "name": "C0311727#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333928", "name": "C1333928#ent", "pos": [11, 12]}}
{"token": ["This", "C1333342#ent", "<e1>", "regulates", "expression", "of", "specific", "C0017337#ent", "<e2>", ",", "through", "a", "Jak-Stat", "pathway", "influence", "male", "reproductive", "function"], "h": {"id": "C1333342", "name": "C1333342#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}}
{"token": ["Constitutive", "expression", "of", "Id1", "did", "not", "interfere", "with", "DNase", "I", "hypersensitivity", "site", "HS2", "of", "the", "locus", "control", "region", "expression", "of", "the", "C1333342#ent", "<e1>", "or", "down-regulation", "of", "the", "endogenous", "Id1", "or", "c-myc", "C0017337#ent", "<e2>", "."], "h": {"id": "C1333342", "name": "C1333342#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [31, 32]}}
{"token": ["In", "contrast", ",", "truncated", "C1706604#ent", "<e1>", "lacking", "its", "first", "26", "amino", "acids", "to", "activate", "C0812228#ent", "<e2>", ",", "resulting", "in", "reduced", "cell", "spreading"], "h": {"id": "C1706604", "name": "C1706604#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [14, 15]}}
{"token": ["The", "C1706604#ent", "<e1>", "GAP", "activity", "was", "necessary", "for", "plexin-B1-induced", "dephosphorylation", "of", "C0812228#ent", "<e2>", "and", "activation", "of", "GSK-3beta", "and", "was", "also", "required", "for", "phosphorylation", "of", "a", "downstream", "kinase", "GSK-3beta", ",", "collapsin", "response", "mediator", "protein-2"], "h": {"id": "C1706604", "name": "C1706604#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "show", "that", "an", "early", "site-specific", "phosphorylation", "of", "C1427734#ent", "<e1>", "is", "essential", "for", "the", "polyadenylation", "of", "C0072454#ent", "<e2>", "mRNA", "and", "its", "subsequent", "translation", ",", "and", "for", "oocyte", "maturation", "."], "h": {"id": "C1427734", "name": "C1427734#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0072454", "name": "C0072454#ent", "pos": [17, 18]}}
{"token": ["The", "L.", "infantum", "C1825546#ent", "<e1>", "expressed", "in", "Escherichia", "coli", "the", "C0034861#ent", "<e2>", "to", "evaluate", "its", "antigenicity", "and", "immunogenicity", "."], "h": {"id": "C1825546", "name": "C1825546#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [10, 11]}}
{"token": ["One", "of", "the", "genes", "involved", "in", "the", "regulation", "of", "cell", "cycle", "control", "wts", "(", "C1367460#ent", "<e1>", ")", ",", "the", "Drosophila", "homolog", "the", "mammalian", "tumor", "suppressor", "gene", "C1259016#ent", "<e2>", "."], "h": {"id": "C1367460", "name": "C1367460#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1259016", "name": "C1259016#ent", "pos": [26, 27]}}
{"token": ["Accordingly", ",", "hyperglycemia-induced", "activation", "of", "C1826724#ent", "<e1>", "and", "AGE", "formation", "are", "prevented", "by", "inhibition", "of", "C1567710#ent", "<e2>", "activity", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1567710", "name": "C1567710#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "the", "protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "inhibitor", "Ro-31", "-", "8425", "suppressed", "the", "C1567710#ent", "<e2>", "cleavage", "and", "DNA", "fragmentation"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1567710", "name": "C1567710#ent", "pos": [16, 17]}}
{"token": ["C1332805#ent", "<e1>", "treatment", "resulted", "in", "destruction", "of", "C0027803#ent", "<e2>", "under", "the", "same", "conditions", "and", "this", "effect", "was", "again", "inhibited", "by", "leupeptin", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027803", "name": "C0027803#ent", "pos": [7, 8]}}
{"token": ["The", "antioxidant", "abilities", "several", "C0071649#ent", "<e1>", "were", "determined", ",", "and", "quercetin", "and", "C0166524#ent", "<e2>", "most", "active", "."], "h": {"id": "C0071649", "name": "C0071649#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0166524", "name": "C0166524#ent", "pos": [12, 13]}}
{"token": ["Several", "substituted", "aryl", "and", "6-alkylamino", "analogues", "of", "the", "anticonvulsant", "purine", "9-(2-fluorobenzyl)-6-(methyl-amino)-9H-purine", "(", "1", ")", "were", "synthesized", "and", "tested", "for", "C0003286#ent", "<e1>", "maximal", "electroshock-induced", "seizures", "(", "C1417092#ent", "<e2>", ")", "in", "rats", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1417092", "name": "C1417092#ent", "pos": [25, 26]}}
{"token": ["Most", "of", "these", "agents", ",", "including", "C0012702#ent", "<e1>", ",", "encainide", ",", "flecainide", ",", "C0543459#ent", "<e2>", ",", "propafenone", "and", "tocainide", ",", "belong", "to", "class", "I", "antiarrhythmics", "whereas", "verapamil", "is", "a", "class", "IV", "antiarrhythmic", "agent"], "h": {"id": "C0012702", "name": "C0012702#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [13, 14]}}
{"token": ["The", "combinations", "of", "C0012702#ent", "<e1>", "plus", "lidocaine", ",", "C0012702#ent", "<e1>", "plus", "C0543459#ent", "<e1>", ",", "C0543459#ent", "<e1>", "plus", "flecainide", ",", "and", "C0012702#ent", "<e1>", "plus", "flecainide", "were", "employed", "to", "study", "their", "effects", "on", "use-dependent", "block", "Vmax", "."], "h": {"id": "C0012702", "name": "C0012702#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [11, 12]}}
{"token": ["C0011847#ent", "<e1>", "reduced", "the", "heart", "rate", "90", "beats/min", ";", "C0033497#ent", "<e2>", "decreased", "the", "heart", "rate", "30", "beats/min", "further", "in", "diabetic", "rats", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}}
{"token": ["Other", "C0029166#ent", "<e1>", "AIDS", "include", "candidiasis", "and", "C0019357#ent", "<e2>"], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019357", "name": "C0019357#ent", "pos": [7, 8]}}
{"token": ["Tf1", ",", "a", "retrotransposon", "from", "fission", "yeast", "has", "C0968917#ent", "<e1>", "and", "coding", "sequences", "the", "C0030946#ent", "<e2>", ",", "reverse", "transcriptase", "integrase", "domains", "retroviral", "pol", "genes"], "h": {"id": "C0968917", "name": "C0968917#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [14, 15]}}
{"token": ["Resistance", "to", "six", "C0360390#ent", "<e1>", "rifampicin", ",", "isoniazid", ",", "streptomycin", ",", "C0546863#ent", "<e2>", ",", "p-amino", "salicylic", "acid", "cycloserine", "was", "studied", "."], "h": {"id": "C0360390", "name": "C0360390#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0546863", "name": "C0546863#ent", "pos": [11, 12]}}
{"token": ["Application", "of", "carbachol", "or", "substance", "P", "contraction", "and", "the", "adrenergic", "agonist", "isoprenaline", "or", "C1366646#ent", "<e1>", "relaxation", "in", "C0085648#ent", "<e2>", "as", "well", "as", "aganglionic", "specimens", "."], "h": {"id": "C1366646", "name": "C1366646#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "tested", "the", "hypothesis", "that", "racemic", "C0022614#ent", "<e1>", "increases", "efferent", "muscle", "sympathetic", "activity", "(", "C1704876#ent", "<e2>", ")", "and", "maintains", "the", "muscle", "sympathetic", "response", "to", "hypotensive", "challenges", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704876", "name": "C1704876#ent", "pos": [15, 16]}}
{"token": ["To", "study", "the", "effects", "of", "tablet", "(", "main", "component", "is", "C0952459#ent", "<e1>", ")", "on", "S100B", "and", "NPY", "of", "cortex", "in", "C0014549#ent", "<e2>", "rats", "."], "h": {"id": "C0952459", "name": "C0952459#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [20, 21]}}
{"token": ["In", "this", "study", ",", "C1428707#ent", "<e1>", "was", "identified", "as", "an", "C1332074#ent", "<e2>", "substrate", "that", "deregulated", "apoptosis", "to", "promote", "melanoma", "tumorigenesis", "."], "h": {"id": "C1428707", "name": "C1428707#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332074", "name": "C1332074#ent", "pos": [10, 11]}}
{"token": ["Levels", "of", "phosphorylated", "PRAS40", "(", "C1428707#ent", "<e1>", ")", "increased", "during", "melanoma", "tumor", "progression", "paralleling", "increasing", "C1332074#ent", "<e2>", "activity", "."], "h": {"id": "C1428707", "name": "C1428707#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332074", "name": "C1332074#ent", "pos": [15, 16]}}
{"token": ["Esterified", "drugs", "as", "imidapril", ",", "C3715025#ent", "<e1>", ",", "and", "oxybutynin", "hydrolyzed", "by", "carboxylesterase", "1", "C1539265#ent", "<e2>", ")", "are", "extensively", "used", "in", "clinical", "practice"], "h": {"id": "C3715025", "name": "C3715025#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539265", "name": "C1539265#ent", "pos": [14, 15]}}
{"token": ["Each", "of", "the", "C0017372#ent", "<e1>", "mutations", "increases", "the", "specific", "catalytic", "activity", "a", "C3887669#ent", "<e2>", "which", "the", "catalytic", "base", "glutamate-165", ",", "has", "been", "changed", "to", "aspartate", "."], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [12, 13]}}
{"token": ["C0017372#ent", "<e1>", "the", "synthesis", "of", "new", "C3887669#ent", "<e2>", "isozymes", "in", "Bacillus", "subtilis"], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [6, 7]}}
{"token": ["Thus", ",", "C0006784#ent", "<e1>", "cleavage", "of", "beta(3", ")", "at", "Tyr(759", ")", "relieves", "c-Src-mediated", "C0812234#ent", "<e2>", "inhibition", ",", "activating", "the", "RhoA", "pathway", "confines", "cell", "spreading", "causes", "cell", "retraction"], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [13, 14]}}
{"token": ["Candidate", "protein", "tyrosine", "kinases", "link", "G-protein-coupled", "receptors", "C0170168#ent", "<e1>", "Src", "family", "kinases", "the", "epidermal", "growth", "factor", "receptor", "Lyn", "and", "C1706351#ent", "<e2>", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706351", "name": "C1706351#ent", "pos": [19, 20]}}
{"token": ["Methoxyverapamil", "(", "D-600", ")", ",", "C0282138#ent", "<e1>", ",", "and", "the", "diphenylbutylpiperidines", ",", "fluspirilene", "and", "C0031935#ent", "<e2>", "were", "found", "not", "to", "affect", "the", "Ca(2+)", "influx", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [14, 15]}}
{"token": ["omega-Conotoxin-MVIIC", "(", "3", "-", "10", "microM", ")", ",", "a", "selective", "C0006684#ent", "<e1>", "greatly", "antagonized", "the", "C0007681#ent", "<e2>", "effect", "of", "genistein", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [15, 16]}}
{"token": ["G17", "also", "induced", "C1333573#ent", "<e1>", "phosphorylation", "assessed", "by", "Western", "blots", "anti-phospho-FOXO3", "antibodies", ",", "and", "C0246569#ent", "<e2>", "inhibited", "this", "effect", "."], "h": {"id": "C1333573", "name": "C1333573#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0246569", "name": "C0246569#ent", "pos": [14, 15]}}
{"token": ["C3890204#ent", "<e1>", "(", "homologous", "recombination", "repair", "protein", "gene", "was", "down-regulated", "2.8-fold", ",", "whereas", "C0127082#ent", "<e2>", "collagenase-1", ")", "gene", "was", "up-regulated", "4.4-fold", "."], "h": {"id": "C3890204", "name": "C3890204#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "report", "a", "family", "with", "multiple", "cases", "of", "PGL", "which", "co-segregates", "with", "a", "novel", "C3273623#ent", "<e1>", "gene", "mutation", "to", "give", "rise", "to", "an", "abnormal", "gene", "product", "C1419909#ent", "<e2>", ")", "."], "h": {"id": "C3273623", "name": "C3273623#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419909", "name": "C1419909#ent", "pos": [27, 28]}}
{"token": ["Neither", "halothane", "nor", "C0022180#ent", "<e1>", "suppressed", "the", "C0030304#ent", "<e2>", "secretory", "response", "evoked", "by", "intravenous", "CCK", "infusion", "(", "10", "Ivy", "Dog", "Units.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0022180", "name": "C0022180#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030304", "name": "C0030304#ent", "pos": [7, 8]}}
{"token": ["Recurrent", "C0162872#ent", "<e1>", "operation", "for", "C0162872#ent", "<e1>", "not", "rare", "."], "h": {"id": "C0162872", "name": "C0162872#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162872", "name": "C0162872#ent", "pos": [1, 2]}}
{"token": ["Enhanced", "expression", "of", "C1332391#ent", "<e1>", "the", "ability", "of", "C0525678#ent", "<e2>", "to", "adjust", "the", "apoptotic", "threshold", "and", "protect", "degenerating", "neurons", "in", "PD", "."], "h": {"id": "C1332391", "name": "C1332391#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [8, 9]}}
{"token": ["During", "a", "clinical", "trial", "C0032911#ent", "<e1>", "for", "human", "C0029106#ent", "<e2>", ",", "Haplorchis", "pumilio", "Looss", "were", "recovered", "from", "the", "stools", "of", "12", "patients", "."], "h": {"id": "C0032911", "name": "C0032911#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0029106", "name": "C0029106#ent", "pos": [8, 9]}}
{"token": ["A", "clinical", "trial", "C0032911#ent", "<e1>", "was", "carried", "out", "in", "patients", "with", "C0029106#ent", "<e2>", "using", "low", "dosages", "with", "30", "and", "60", "days", "follow-up", "."], "h": {"id": "C0032911", "name": "C0032911#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0029106", "name": "C0029106#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "some", "analogues", "of", "2", "-", "5A", "may", "form", "a", "class", "of", "anti-HIV-1", "drugs", "with", "possible", "C2936489#ent", "<e1>", "include", "activation", "of", "latent", "C0014241#ent", "<e2>", "inhibition", "of", "reverse", "transcription"], "h": {"id": "C2936489", "name": "C2936489#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014241", "name": "C0014241#ent", "pos": [23, 24]}}
{"token": ["Treatments", "for", "leakage", "included", "colostomy", "(", "three", "C0042679#ent", "<e1>", ")", ",", "C1423571#ent", "<e2>", "construction", "(", "one", "C0042679#ent", "<e1>", ")", "and", "conservative", "treatment", "three", "C1423571#ent", "<e2>", ")", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423571", "name": "C1423571#ent", "pos": [11, 12]}}
{"token": ["The", "authors", "investigated", "the", "effects", "of", "intravenous", "anesthetics", "C0936073#ent", "<e1>", "and", "ketamine", ",", "and", "the", "C0002934#ent", "<e2>", "lidocaine", "and", "bupivacaine", ",", "on", "the", "activity", "of", "glutamate", "transporter", "type", "2", "EAAT2", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002934", "name": "C0002934#ent", "pos": [15, 16]}}
{"token": ["It", "is", "best", "treated", "with", "C0728960#ent", "<e1>", ",", "avoidance", "of", "early", "surgical", "debridement", "and", "C0010980#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [14, 15]}}
{"token": ["The", "chemoattractant", "formyl-methionyl-leucyl-phenylalanine", "fMLP", ")", "caused", "a", "rapid", "(", "30", "s", ")", "and", "transient", "increase", "(", "1.6-fold", ")", "in", "C0011967#ent", "<e1>", ",", "but", "no", "increase", "in", "C1416571#ent", "<e2>", "."], "h": {"id": "C0011967", "name": "C0011967#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1416571", "name": "C1416571#ent", "pos": [26, 27]}}
{"token": ["In", "addition", ",", "Res", "inhibited", "the", "formation", "of", "both", "diacylglycerol", "(", "C0011967#ent", "<e1>", ")", "and", "ether-linked", "acylglycerol", "(", "C1416571#ent", "<e2>", ")", "induced", "by", "fMLP", "and", "by", "PMA", "."], "h": {"id": "C0011967", "name": "C0011967#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416571", "name": "C1416571#ent", "pos": [18, 19]}}
{"token": ["Fusion", "proteins", "domain", "1", "D1-Fc", ")", "or", "domain", "3", "D3-Fc", ")", "of", "C1419426#ent", "<e1>", "inhibited", "axon", "growth", "cerebellar", "granule", "neurons", "when", "the", "C0086376#ent", "<e2>", "were", "substrate-bound", "."], "h": {"id": "C1419426", "name": "C1419426#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [22, 23]}}
{"token": ["We", "conclude", "that", "defibrination", "with", "C0002823#ent", "<e1>", "delays", "the", "development", "of", "renal", "fibrin", "deposition", "and", "C0017658#ent", "<e2>", "and", "improves", "survival", "in", "BXSB", "mice", "."], "h": {"id": "C0002823", "name": "C0002823#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [15, 16]}}
{"token": ["This", "was", "achieved", "by", "the", "introduction", "of", "the", "yeast", "prephenate", "dehydrogenase", "gene", "C0034345#ent", "<e1>", ")", "into", "transgenic", "plants", "overexpressing", "C3280065#ent", "<e2>", "."], "h": {"id": "C0034345", "name": "C0034345#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3280065", "name": "C3280065#ent", "pos": [19, 20]}}
{"token": ["In", "homozygous", "CCK2", "receptor-deficient", "mice", ",", "the", "expression", "of", "C3274837#ent", "<e1>", "5-fold", "higher", "than", "in", "C2987364#ent", "<e2>", "animals", "."], "h": {"id": "C3274837", "name": "C3274837#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [15, 16]}}
{"token": ["We", "found", "that", "the", "Black", "grouse", "Tetrao", "tetrix", "possess", "low", "numbers", "of", "Mhc", "class", "II", "B", "C1332672#ent", "<e1>", ")", "and", "Y", "(", "YLB", ")", "C1417679#ent", "<e2>", "with", "variable", "diversity", "and", "expression", "."], "h": {"id": "C1332672", "name": "C1332672#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["The", "influence", "of", "C0014544#ent", "<e1>", "on", "social", "outcome", "greater", "than", "found", "in", "other", "childhood", "C0022661#ent", "<e2>", "control", "groups"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [14, 15]}}
{"token": ["C0014544#ent", "<e1>", "is", "a", "C0022661#ent", "<e2>", "treatment", "consists", "of", "controlling", "seizures", "with", "antiepileptics", "that", "very", "often", "induce", "strong", "undesirable", "side", "effects", "may", "limit", "treatment", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [4, 5]}}
{"token": ["Parkinson's", "disease", "a", "C0020179#ent", "<e1>", "the", "central", "nervous", "system", "by", "tremor", ",", "rigidity", "and", "C0233565#ent", "<e2>", ",", "usually", "affects", "those", "over", "the", "age", "of", "50", "."], "h": {"id": "C0020179", "name": "C0020179#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0233565", "name": "C0233565#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "we", "showed", "that", "apoL1", "is", "inducible", "by", "p53", "in", "C3538682#ent", "<e1>", "is", "a", "C1414515#ent", "<e2>", "high", "affinity", "for", "phosphatidic", "acid", "PA", ")", "and", "cardiolipin", "(", "CL", ")", "."], "h": {"id": "C3538682", "name": "C3538682#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414515", "name": "C1414515#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", ",", "biochemical", "and", "immunohistochemical", "techniques", "applied", "to", "identify", "in", "mice", "the", "localization", "of", "intravenously", "administered", "C0102139#ent", "<e1>", "(", "human", "modified", "C0017768#ent", "<e2>", "."], "h": {"id": "C0102139", "name": "C0102139#ent", "pos": [18, 19]}, "relation": "has_structural_class", "t": {"id": "C0017768", "name": "C0017768#ent", "pos": [23, 24]}}
{"token": ["Replacement", "of", "the", "deficient", "enzyme", "with", "C0102139#ent", "<e1>", "or", "the", "recombinant", "from", "of", "C0017768#ent", "<e2>", "effective", "in", "treating", "the", "disease", "."], "h": {"id": "C0102139", "name": "C0102139#ent", "pos": [6, 7]}, "relation": "has_structural_class", "t": {"id": "C0017768", "name": "C0017768#ent", "pos": [13, 14]}}
{"token": ["C0102139#ent", "<e1>", "is", "a", "form", "of", "C0017768#ent", "<e2>", "enriched", "with", "terminal", "mannose", "moieties", ",", "so", "as", "to", "\"", "target", "\"", "the", "preparation", "to", "the", "high-affinity", "macrophage", "receptor", "patients", "with", "Gaucher", "disease"], "h": {"id": "C0102139", "name": "C0102139#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0017768", "name": "C0017768#ent", "pos": [6, 7]}}
{"token": ["Northern", "and", "Southern", "blots", "at", "least", "two", "distinct", "C1417679#ent", "<e1>", "that", "encoded", "the", "C1413546#ent", "<e2>", "that", "these", "C1417679#ent", "<e1>", "were", "transcribed", "specifically", "in", "the", "newborn", "larvae", "stage", "."], "h": {"id": "C1413546", "name": "C1413546#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}}
{"token": ["The", "C0014442#ent", "<e1>", "had", "low", "activity", "gentiobiose", ",", "C0073969#ent", "<e2>", "and", "beta-methyl-D-glucoside", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0073969", "name": "C0073969#ent", "pos": [8, 9]}}
{"token": ["The", "Km", "and", "Vmax", "values", "of", "the", "C0014442#ent", "<e1>", "for", "cellobiose", "and", "C0073969#ent", "<e2>", "were", "5.34", "mM", ",", "2.57", "micromol/(mL.s", ")", ",", "and", "3.09", "mM", ",", "1.34", "micromol/(mL.s", ")", ",", "respectively", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0073969", "name": "C0073969#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "whether", "clinical", "characteristics", "are", "correlated", "with", "increased", "levels", "of", "C1522073#ent", "<e1>", "TGF-beta", "2", ")", "in", "aqueous", "humor", "in", "C0017601#ent", "<e2>", "eyes", "."], "h": {"id": "C1522073", "name": "C1522073#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [20, 21]}}
{"token": ["In", "isoproterenol-treated", "Purkinje", "fibers", "pA2", "for", "C0027302#ent", "<e1>", "was", "8.2", "and", "7.7", "for", "C0033497#ent", "<e2>", "."], "h": {"id": "C0027302", "name": "C0027302#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [13, 14]}}
{"token": ["To", "study", "the", "expression", "of", "C1414404#ent", "<e1>", "NSE", ")", "and", "olfactory", "marker", "protein", "C0028978#ent", "<e2>", ")", "in", "the", "developing", "olfactory", "mucosa", "human", "fetuses", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [13, 14]}}
{"token": ["The", "system", "consisted", "of", "a", "drug-containing", "C0017237#ent", "<e1>", "capsule", ",", "a", "swelling", "layer", "C3484462#ent", "<e2>", "(", "Ac-Di-Sol", ")", "and", "a", "binder", ",", "and", "an", "outer", "ethylcellulose", "coating", "."], "h": {"id": "C0017237", "name": "C0017237#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3484462", "name": "C3484462#ent", "pos": [13, 14]}}
{"token": ["The", "role", "of", "blood", "pressure", "examined", "in", "SHRs", "treated", "chronically", "with", "the", "antihypertensive", "drug", "C0006938#ent", "<e1>", ",", "beginning", "in", "utero", ",", "and", "in", "C0020544#ent", "<e2>", "Sprague-Dawley", "rats", "SDs", ")", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020544", "name": "C0020544#ent", "pos": [23, 24]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "determine", "the", "effect", "of", "chronic", "treatment", "C0006938#ent", "<e1>", "on", "reactivity", "of", "aortic", "rings", "both", "normotensive", "and", "C0020544#ent", "<e2>", "rats", "when", "C0006938#ent", "<e1>", "was", "no", "longer", "present", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020544", "name": "C0020544#ent", "pos": [24, 25]}}
{"token": ["In", "conclusion", ",", "C0006938#ent", "<e1>", "seems", "to", "be", "an", "effective", "antihypertensive", "agent", "essential", "and", "C0020544#ent", "<e2>"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020544", "name": "C0020544#ent", "pos": [14, 15]}}
{"token": ["During", "the", "administration", "of", "N2O/O2", "and", "halothane", "via", "a", "face", "mask", "tachycardia", "noted", "and", "C0026837#ent", "<e1>", "followed", "the", "application", "of", "C0012792#ent", "<e2>", "for", "intubation", "."], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [20, 21]}}
{"token": ["The", "case", "shows", "that", "prolonged", "C0026837#ent", "<e1>", "myalgia", "may", "occur", "after", "C0012792#ent", "<e2>", "in", "patients", "with", "atypical", "cholinesterase", "despite", "pretreatment", "with", "pancuronium", "."], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [11, 12]}}
{"token": ["Recently", ",", "an", "immunohistochemical", "panel", "antibodies", "against", "C0242957#ent", "<e1>", ",", "oestrogen", "receptor", "ER", ")", ",", "epidermal", "growth", "factor", "receptor", "EGFR", ")", "and", "C1416713#ent", "<e2>", "(", "CK", ")", "5/6", "was", "reported", "to", "identify", "basal-like", "breast", "carcinomas", "as", "defined", "by", "cDNA", "microarrays"], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416713", "name": "C1416713#ent", "pos": [22, 23]}}
{"token": ["In", "these", "patients", ",", "C0354872#ent", "<e1>", "was", "definitely", "effective", "in", "relieving", "the", "C0013384#ent", "<e2>", "over", "an", "extended", "period", "of", "time", "."], "h": {"id": "C0354872", "name": "C0354872#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [12, 13]}}
{"token": ["We", "evaluated", "here", "the", "role", "of", "a", "coding", "variation", "Ser249Pro", ",", "in", "the", "C1705007#ent", "<e1>", "the", "pathogenesis", "of", "asthma", ",", "C0011615#ent", "<e2>", "AD", ")", "and", "chronic", "obstructive", "pulmonary", "disease", "COPD", ")", "."], "h": {"id": "C1705007", "name": "C1705007#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [20, 21]}}
{"token": ["Message", "levels", "C1415892#ent", "<e1>", ",", "GARG-39", ",", "and", "GARG-49/IRG2", "are", "increased", "by", "C0175697#ent", "<e2>", "stimulation", "in", "Swiss", "3T3", "cells", "in", "peritoneal", "macrophages"], "h": {"id": "C1415892", "name": "C1415892#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [12, 13]}}
{"token": ["We", "have", "previously", "reported", "that", "there", "is", "a", "decreased", "ability", "of", "glucocorticoid", "receptors", "GR", ")", "to", "bind", "to", "the", "C0812382#ent", "<e1>", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "after", "C0011777#ent", "<e2>"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [28, 29]}}
{"token": ["The", "efficacy", "of", "C1332124#ent", "<e1>", "antagonists", "warrants", "study", "as", "an", "alternative", "treatment", "to", "loop", "diuretics", "C0020488#ent", "<e2>", "these", "patients", "."], "h": {"id": "C1332124", "name": "C1332124#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020488", "name": "C0020488#ent", "pos": [15, 16]}}
{"token": ["In", "particular", ",", "C1705616#ent", "<e1>", "arrests", "cells", "G(2)-M", "via", "down-regulation", "of", "C3811768#ent", "<e2>", ",", "as", "suggested", "by", "the", "decreased", "sensitivity", "to", "C1705616#ent", "<e1>", "acquired", "by", "Cdc2-overexpressing", "cells", "."], "h": {"id": "C3811768", "name": "C3811768#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [3, 4]}}
{"token": ["Plant", "constituents", "include", "vitamin", "derivatives", ",", "phenolic", "and", "C2348680#ent", "<e1>", "organic", "sulfur", "compounds", "isothiocyanates", ",", "curcumins", ",", "fatty", "acids", "C0950252#ent", "<e2>", "."], "h": {"id": "C2348680", "name": "C2348680#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0950252", "name": "C0950252#ent", "pos": [19, 20]}}
{"token": ["We", "discuss", "the", "role", "of", "Leishmania", "FABP", "compare", "the", "immunological", "reactions", "with", "serum", "samples", "from", "other", "C0033740#ent", "<e1>", "as", "toxoplasma", "and", "C0041234#ent", "<e2>", "as", "well", "as", "bacterial", "infections", "as", "tuberculosis", "and", "syphilis", "."], "h": {"id": "C0033740", "name": "C0033740#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0041234", "name": "C0041234#ent", "pos": [21, 22]}}
{"token": ["Chagas'", "disease", "a", "C0033740#ent", "<e1>", "by", "the", "C0041234#ent", "<e2>"], "h": {"id": "C0033740", "name": "C0033740#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0041234", "name": "C0041234#ent", "pos": [7, 8]}}
{"token": ["Rats", "received", "anti-NGF", "on", "postnatal", "days", "PNDs", ")", "2", "-", "12", ",", "and", "choline", "acetyltransferase", "C0124604#ent", "<e1>", ")", "activity", "was", "measured", "on", "C1417807#ent", "<e2>", "16", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [22, 23]}}
{"token": ["When", "using", "chemical", "inhibition", "however", ",", "an", "average", "inhibition", "percentage", "of", "83", "were", "obtained", "with", "C0029309#ent", "<e1>", ",", "a", "human", "C3850062#ent", "<e2>"], "h": {"id": "C0029309", "name": "C0029309#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3850062", "name": "C3850062#ent", "pos": [20, 21]}}
{"token": ["C1259877#ent", "<e1>", "PKC", ")", "signaling", "pathways", "an", "important", "role", "in", "cell", "survival", "C0011609#ent", "<e2>"], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011609", "name": "C0011609#ent", "pos": [12, 13]}}
{"token": ["Drug", "sensitivity", "restored", "in", "cells", "with", "active", "v-Abl", "PTK", "by", "simultaneous", "addition", "of", "calphostin", "C", "an", "inhibitor", "of", "C1259877#ent", "<e1>", "suggesting", "a", "role", "for", "C1259877#ent", "<e1>", "the", "suppression", "of", "C0011609#ent", "<e1>", "v-Abl", "PTK"], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0011609", "name": "C0011609#ent", "pos": [29, 30]}}
{"token": ["Type", "II", "collagenopathies", "a", "wide", "spectrum", "of", "clinical", "severity", "from", "lethal", "achondrogenesis", "type", "II", ",", "hypochondrogenesis", ",", "through", "severe", "forms", "like", "spondyloepiphyseal", "dysplasia", "congenita", "spondyloepimetaphyseal", "dysplasia", "congenita", "C4082167#ent", "<e1>", "to", "the", "mild", "forms", "C2020284#ent", "<e2>", "early", "osteoarthritis"], "h": {"id": "C4082167", "name": "C4082167#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C2020284", "name": "C2020284#ent", "pos": [33, 34]}}
{"token": ["C0029454#ent", "<e1>", "MOP", ")", "is", "an", "C3899988#ent", "<e2>", "which", "osteoclast", "dysfunction", "results", "in", "excessive", "bone", "deposition", "early", "infant", "."], "h": {"id": "C0029454", "name": "C0029454#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [6, 7]}}
{"token": ["While", "diffuse", "C0268747#ent", "<e1>", "traditionally", "described", "as", "being", "the", "glomerulopathy", "of", "C0950121#ent", "<e2>", "DDS", ")", ",", "the", "podocyte", "proliferative", "lesions", "may", "be", "overlooked", "in", "these", "DDS", "cases", "."], "h": {"id": "C0268747", "name": "C0268747#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0950121", "name": "C0950121#ent", "pos": [11, 12]}}
{"token": ["C0268747#ent", "<e1>", "one", "of", "the", "most", "consistent", "findings", "in", "C0950121#ent", "<e2>", "patients", "and", "can", "be", "caused", "by", "dominant", "mutations", "in", "the", "Wilms'", "tumor", "1", "gene", "WT1", ")", "."], "h": {"id": "C0268747", "name": "C0268747#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0950121", "name": "C0950121#ent", "pos": [9, 10]}}
{"token": ["C0268747#ent", "<e1>", "in", "the", "isolated", "form", "and", "as", "part", "of", "the", "C0950121#ent", "<e2>"], "h": {"id": "C0268747", "name": "C0268747#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0950121", "name": "C0950121#ent", "pos": [11, 12]}}
{"token": ["The", "NAD(P)H", ":", "C1335186#ent", "<e1>", "Nmo-1", ")", "codes", "for", "a", "C1136197#ent", "<e2>", "also", "called", "DT", "diaphorase", "EC", "1.6.99.2", ")", "believed", "to", "play", "a", "central", "role", "in", "protection", "against", "oxidative", "stress"], "h": {"id": "C1335186", "name": "C1335186#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [10, 11]}}
{"token": ["All", "of", "these", "characteristics", "were", "shared", "with", "the", "rat", "brain", "enzyme", "indicating", "that", "the", "C0031727#ent", "<e1>", "in", "mouse", "brain", "was", "a", "C1871221#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1871221", "name": "C1871221#ent", "pos": [21, 22]}}
{"token": ["Mucous", "membrane", "pemphigoid", "C0623362#ent", "<e1>", ")", ",", "also", "known", "as", "C0030804#ent", "<e2>", "is", "a", "serious", ",", "autoimmune", ",", "blistering", "disorder", "can", "result", "in", "blindness", "and", "other", "complications", "as", "a", "result", "of", "scarring", "of", "the", "mucous", "membranes"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030804", "name": "C0030804#ent", "pos": [10, 11]}}
{"token": ["Mucous", "membrane", "pemphigoid", "C0623362#ent", "<e1>", ")", ",", "also", "known", "as", "C0030804#ent", "<e2>", "CP", ")", ",", "is", "an", "autoimmune", "mucocutaneous", "blistering", "disease", "can", "lead", "to", "blindness", "and/or", "death", "from", "sudden", "asphyxiation", ",", "secondary", "to", "scarring", "process"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030804", "name": "C0030804#ent", "pos": [10, 11]}}
{"token": ["Binding", "of", "phosphorylase", "kinase", "C0002245#ent", "<e1>", "occurs", "only", "in", "the", "presence", "of", "Ca2", "+", "and", "C1417500#ent", "<e2>", "+", "."], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [15, 16]}}
{"token": ["C0002245#ent", "<e1>", "had", "eight", "identical", "and", "independent", "binding", "sites", "C1417500#ent", "<e2>", "+", "ion", ",", "which", "showed", "non-cooperativity", "in", "the", "binding", "process"], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [9, 10]}}
{"token": ["We", "discuss", "the", "implications", "these", "results", "might", "have", "for", "the", "airway", "epithelium", "and", "its", "relation", "to", "airway", "inflammation", "C0085129#ent", "<e1>", "associated", "with", "asthma", "and", "other", "C0699949#ent", "<e2>"], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0699949", "name": "C0699949#ent", "pos": [25, 26]}}
{"token": ["However", ",", "the", "C0085129#ent", "<e1>", "BH", ")", "in", "CS", "without", "any", "apparent", "lower", "C0699949#ent", "<e2>", "not", "fully", "understood", "nor", "are", "the", "effects", "of", "treatment", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0699949", "name": "C0699949#ent", "pos": [13, 14]}}
{"token": ["Troponin", "T", "C1420827#ent", "<e1>", ")", ",", "a", "sensitive", "marker", "for", "C0010054#ent", "<e2>", "and", "various", "coagulation", "variables", "were", "measured", "in", "the", "perioperative", "period", "."], "h": {"id": "C1420827", "name": "C1420827#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [10, 11]}}
{"token": ["In", "conclusion", ",", "the", "authors", "emphasise", "the", "value", "of", "the", "use", "of", "C1420827#ent", "<e1>", "in", "postoperative", "hypertensive", "states", ",", "in", "particular", "when", "associated", "with", "C0010054#ent", "<e2>"], "h": {"id": "C1420827", "name": "C1420827#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [24, 25]}}
{"token": ["Fabry", "disease", "an", "X-linked", "recessive", "C0085078#ent", "<e1>", "it", "is", "due", "to", "C0002986#ent", "<e2>", "and", "its", "clinical", "course", "repeated", "small", "artery", "strokes"], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0002986", "name": "C0002986#ent", "pos": [11, 12]}}
{"token": ["Unlike", "for", "some", "C0085078#ent", "<e1>", "there", "is", "limited", "primary", "nervous", "system", "in", "C0002986#ent", "<e2>"], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0002986", "name": "C0002986#ent", "pos": [12, 13]}}
{"token": ["We", "show", "that", "C1705328#ent", "<e1>", "uses", "PAK", "to", "directly", "activate", "transmembrane", "guanylyl", "cyclases", "C1704697#ent", "<e2>", ")", ",", "leading", "to", "increased", "cellular", "cGMP", "levels", "."], "h": {"id": "C1705328", "name": "C1705328#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704697", "name": "C1704697#ent", "pos": [13, 14]}}
{"token": ["The", "mechanism", "by", "which", "N-CoR", "represses", "C1332461#ent", "<e1>", "the", "direct", "or", "indirect", "recruitment", "of", "histone", "deacetylases", "C1422386#ent", "<e2>", ")", "."], "h": {"id": "C1332461", "name": "C1332461#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422386", "name": "C1422386#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "the", "association", "between", "cerebral", "venous", "thrombosis", "hereditary", "resistance", "C0483249#ent", "<e1>", "APC", ")", "in", "12", "consecutive", "German", "patients", "with", "C0151945#ent", "<e2>", "in", "187", "controls", "without", "a", "history", "of", "thrombotic", "disorder"], "h": {"id": "C0483249", "name": "C0483249#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151945", "name": "C0151945#ent", "pos": [20, 21]}}
{"token": ["C1333242#ent", "<e1>", "also", "interacts", "with", "C1334032#ent", "<e2>", "HDAC1", ")", ",", "the", "co-repressor", "SIN3A", "and", "the", "ATP-dependent", "chromatin", "remodeling", "enzyme", "hSNF2H", "."], "h": {"id": "C1333242", "name": "C1333242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [5, 6]}}
{"token": ["The", "parents", "had", "previously", "had", "two", "children", ":", "a", "healthy", "boy", "a", "boy", "with", "C0015625#ent", "<e1>", "belonging", "to", "C1414529#ent", "<e2>", "FAC", ")", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [14, 15]}, "relation": "disease_has_associated_gene", "t": {"id": "C1414529", "name": "C1414529#ent", "pos": [18, 19]}}
{"token": ["The", "polypeptide", "encoded", "by", "the", "Fanconi", "anemia", "C0015625#ent", "<e1>", ")", "complementation", "group", "C", "gene", "C1414529#ent", "<e2>", ",", "binds", "to", "a", "group", "of", "cytoplasmic", "proteins", "in", "vitro", "may", "form", "a", "multimeric", "complex"], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C1414529", "name": "C1414529#ent", "pos": [14, 15]}}
{"token": ["In", "vivo", "phosphopeptide", "mapping", "revealed", "phosphopeptides", "common", "to", "those", "generated", "in", "vitro", "AKT", ",", "C2827383#ent", "<e1>", "MEK1", ",", "and", "MKK6", ",", "suggesting", "that", "these", "C0031727#ent", "<e2>", "may", "phosphorylate", "NS5A", "in", "mammalian", "cells"], "h": {"id": "C2827383", "name": "C2827383#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [24, 25]}}
{"token": ["The", "C2827383#ent", "<e1>", "represent", "two", "isoforms", "of", "the", "same", "C0031727#ent", "<e2>", "which", "are", "derived", "by", "differential", "splicing", "a", "common", "gene", "."], "h": {"id": "C2827383", "name": "C2827383#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}}
{"token": ["She", "remained", "jaundiced", "and", "a", "liver", "biopsy", "C1623038#ent", "<e1>", "with", "regenerating", "nodules", ",", "portal", "chronic", "inflammation", "bile", "duct", "proliferation", ",", "and", "C0008370#ent", "<e2>"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008370", "name": "C0008370#ent", "pos": [21, 22]}}
{"token": ["Patients", "who", "developed", "C1623038#ent", "<e1>", "often", "presented", "with", "severe", "and", "persistent", "neonatal", "C0008370#ent", "<e2>", ",", "mimicking", "extrahepatic", "biliary", "atresia", "leading", "to", "laparotomy", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008370", "name": "C0008370#ent", "pos": [12, 13]}}
{"token": ["Mutants", "lacking", "lbtA", "or", "lbtB", "were", "defective", "for", "legiobactin", ",", "producing", "40", "to", "70", "%", "less", "C1366459#ent", "<e1>", "reactivity", "in", "deferrated", "chemically", "defined", "medium", "(", "C3813548#ent", "<e2>", ")", "."], "h": {"id": "C1366459", "name": "C1366459#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3813548", "name": "C3813548#ent", "pos": [25, 26]}}
{"token": ["Both", "the", "fluorescent", "treponemal", "antibody", "absorption", "FTS-ABS", ")", "test", "and", "C0036916#ent", "<e1>", "VDRL", ")", "test", "for", "C0039128#ent", "<e2>", "were", "performed", "routinely", "on", "113", "men", "with", "histories", "of", "genital", "ulcerations"], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [16, 17]}}
{"token": ["In", "the", "former", "West", "Germany", ",", "in", "specific", "C0036916#ent", "<e1>", "legislation", "passed", "in", "1953", ",", "only", "C0039128#ent", "<e2>", ",", "gonorrhoea", ",", "ulcus", "molle", "and", "lymphogranuloma", "venereum", "defined", "as", "C0036916#ent", "<e1>", "subject", "to", "mandatory", "notification", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [16, 17]}}
{"token": ["Although", "not", "free", "of", "complications", ",", "C3540047#ent", "<e1>", "are", "generally", "safe", "when", "used", "to", "treat", "C0015403#ent", "<e2>"], "h": {"id": "C3540047", "name": "C3540047#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015403", "name": "C0015403#ent", "pos": [15, 16]}}
{"token": ["As", "it", "stands", ",", "the", "first", "sentence", "in", "the", "second", "paragraph", "of", "my", "note", "makes", "it", "appear", "that", "C0591410#ent", "<e1>", "is", "the", "C0014996#ent", "<e2>", "alone", ",", "and", "that", "is", "incorrect", "."], "h": {"id": "C0591410", "name": "C0591410#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014996", "name": "C0014996#ent", "pos": [22, 23]}}
{"token": ["Viral", "cytotoxicity", "found", "to", "be", "crucial", "for", "organ", "pathology", "both", "during", "acute", "and", "persistent", "infection", ",", "indicating", "that", "C0027059#ent", "<e1>", "a", "virus-induced", "rather", "than", "an", "C0021053#ent", "<e2>"], "h": {"id": "C0027059", "name": "C0027059#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [25, 26]}}
{"token": ["The", "high", "incidence", "of", "middle-ear", "dysfunction", "and", "the", "associated", "C0018777#ent", "<e1>", "and", "the", "progressive", "C0018784#ent", "<e2>", "found", "in", "Down's", "Syndrome", "discussed", "."], "h": {"id": "C0018777", "name": "C0018777#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [14, 15]}}
{"token": ["Although", "most", "patients", "had", "a", "C0018777#ent", "<e1>", "17", "%", "of", "patients", "demonstrated", "profound", "C0018784#ent", "<e2>", "to", "the", "lesion", ",", "and", "facial", "nerve", "sequelae", "were", "noted", "in", "nearly", "10", "%", "of", "cases", "."], "h": {"id": "C0018777", "name": "C0018777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [13, 14]}}
{"token": ["Following", "our", "own", "findings", "and", "recent", "results", "from", "the", "tumor", "virus", "research", "we", "want", "to", "point", "out", "that", "C1419876#ent", "<e1>", "has", "to", "be", "considered", "as", "a", "C0012634#ent", "<e2>", "its", "proper", "etiology", "and", "clinical", "appearance"], "h": {"id": "C1419876", "name": "C1419876#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [26, 27]}}
{"token": ["In", "addition", ",", "some", "bacteria", "and", "C0162628#ent", "<e1>", "been", "shown", "to", "affect", "the", "C1705401#ent", "<e2>", "directly", "."], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [13, 14]}}
{"token": ["C0016860#ent", "<e1>", "had", "no", "effect", "the", "Na", ",", "K-ATPase", "activity", "C1705556#ent", "<e2>", "levels", "of", "the", "TALH", "cells", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["Maleate", "had", "no", "effect", "the", "distribution", "or", "staining", "intensity", "of", "four", "other", "brush", "border", "markers", ",", "C1447020#ent", "<e1>", "and", "various", "lectins", "(", "C0062186#ent", "<e2>", "peanut", "lectin", "elderberry", "bark", "lectin", ")", "."], "h": {"id": "C1447020", "name": "C1447020#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0062186", "name": "C0062186#ent", "pos": [22, 23]}}
{"token": ["Our", "results", "suggests", "that", "there", "is", "tubular", "dysfunction", "the", "early", "stage", "IDDM", "children", "even", "before", "there", "is", "any", "clinical", "evidence", "C0017661#ent", "<e1>", ",", "and", "urinary", "C1417593#ent", "<e2>", "may", "reflect", "glycemic", "control", "in", "such", "patients", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1417593", "name": "C1417593#ent", "pos": [25, 26]}}
{"token": ["Patients", "with", "membranous", "nephropathy", "membranoproliferative", "glomerulonephritis", "focal", "segmental", "glomerulosclerosis", "obstructive", "pyelonephritis", "nephrosclerosis", ",", "and", "minimal", "change", "C0017661#ent", "<e1>", "generally", "had", "urinary", "C1417593#ent", "<e2>", "and", "beta", "2", "M", "levels", "more", "than", "3", "SDs", "above", "those", "seen", "in", "normal", "subjects"], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417593", "name": "C1417593#ent", "pos": [21, 22]}}
{"token": ["The", "mainstream", "treatment", "C1720797#ent", "<e1>", "antimicrobials", ",", "non-steroidal", "anti-inflammatory", "medications", "and", "C0001645#ent", "<e2>", "."], "h": {"id": "C1720797", "name": "C1720797#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "the", "pressure", "of", "ischemia", "or", "infarction", "C2712370#ent", "<e1>", "the", "frequency", "content", "of", "C0042510#ent", "<e2>", "in", "a", "complex", "fashion"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [15, 16]}}
{"token": ["C2712370#ent", "<e1>", "the", "ARI", "restitution", "to", "the", "steep", "slope", "causes", "C0042510#ent", "<e2>", "in", "a", "model", "heart"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [10, 11]}}
{"token": ["To", "fully", "evaluate", "the", "effects", "of", "Sec", "on", "C1537381#ent", "<e1>", "and", "kinetics", ",", "C1423888#ent", "<e2>", "Grx3", ")", "and", "all", "three", "Sec", "variants", "of", "its", "conserved", "(11)CXX(14)C", "active", "site", "chemically", "synthesized"], "h": {"id": "C1537381", "name": "C1537381#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1423888", "name": "C1423888#ent", "pos": [13, 14]}}
{"token": ["Several", "mutations", "have", "been", "found", "in", "the", "leucine-rich", "repeat", "kinase", "2", "gene", "LRRK2", ")", ",", "encoding", "the", "C2697861#ent", "<e1>", "which", "are", "associated", "with", "autosomal", "dominant", "C0030567#ent", "<e2>"], "h": {"id": "C2697861", "name": "C2697861#ent", "pos": [17, 18]}, "relation": "gene_associated_with_disease", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [25, 26]}}
{"token": ["A", "purely", "mutagenic", "(", "neither", "cytotoxic", ",", "nor", "C0072454#ent", "<e1>", ")", "environment", "will", "favor", "effective", "C1333237#ent", "<e2>", "whereas", "any", "growth-limiting", "conditions", "(", "telomerase", "deficiency", "anticancer", "drugs", "will", "select", "for", "genetically", "unstable", "cells", "."], "h": {"id": "C0072454", "name": "C0072454#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [15, 16]}}
{"token": ["Amiodarone", "(", "C0242383#ent", "<e1>", ")", "is", "an", "antiarrhythmic", "drug", "contains", "37", "%", "of", "C0885449#ent", "<e2>", "."], "h": {"id": "C0242383", "name": "C0242383#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0885449", "name": "C0885449#ent", "pos": [13, 14]}}
{"token": ["C1412504#ent", "<e1>", "and", "CAP60", "are", "also", "required", "for", "capsule", "production", ",", "a", "virulence", "factor", "and", "C1412504#ent", "<e1>", "confers", "resistance", "to", "the", "C0016277#ent", "<e1>"], "h": {"id": "C1412504", "name": "C1412504#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [21, 22]}}
{"token": ["PMS777", ",", "both", "a", "C0235480#ent", "<e1>", "antagonist", "and", "a", "new", "potent", "C0001046#ent", "<e2>", "recently", "demonstrated", "to", "reverse", "scopolamine-induced", "amnesia", "in", "mice", "without", "toxicity", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001046", "name": "C0001046#ent", "pos": [11, 12]}}
{"token": ["2,5-Disubstituted", "tetrahydrofuran", "derivatives", "present", "a", "dual", "activity", "they", "are", "effective", "C0235480#ent", "<e1>", "antagonists", "and", "C0001046#ent", "<e2>"], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001046", "name": "C0001046#ent", "pos": [14, 15]}}
{"token": ["C0010287#ent", "<e1>", ",", "glycine", ",", "GABA", ",", "and", "C0376261#ent", "<e2>", "were", "also", "reduced", "but", "not", "significantly", "."], "h": {"id": "C0010287", "name": "C0010287#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [8, 9]}}
{"token": ["Bile", "was", "mostly", "composed", "of", "desalkyl", "C0288165#ent", "<e1>", "and", "6'-O-glucuronide", "C0288165#ent", "<e1>", ",", "with", "C1254351#ent", "<e1>", "4-O-glucuronide", "C0288165#ent", "<e1>", ",", "and", "conjugates", "of", "desalkyl", "C0288165#ent", "<e1>", "as", "significant", "components", "."], "h": {"id": "C0288165", "name": "C0288165#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["Concomitant", "use", "of", "C0288165#ent", "<e1>", "and", "rifabutin", "at", "the", "recommended", "dose", "each", "C1254351#ent", "<e2>", "is", "discouraged", "."], "h": {"id": "C0288165", "name": "C0288165#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["As", "more", "has", "been", "learned", "about", "the", "etiopathogenesis", "of", "C0004943#ent", "<e1>", "novel", "anti-inflammatory", "drugs", "immunosuppressants", ",", "C0016018#ent", "<e2>", "and", "anticoagulants", "have", "helped", "to", "achieve", "remarkable", "progress", "of", "treatment", "."], "h": {"id": "C0004943", "name": "C0004943#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [16, 17]}}
{"token": ["On", "the", "basis", "of", "these", "and", "previous", "results", ",", "we", "propose", "that", "C1412305#ent", "<e1>", "to", "a", "group", "of", "C3540790#ent", "<e2>", "whose", "substrates", "act", "to", "shift", "pre-existing", "equilibria", "toward", "catalytically", "active", "states", "."], "h": {"id": "C1412305", "name": "C1412305#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [18, 19]}}
{"token": ["Signs", "and", "symptoms", "of", "CCM", "include", "sensory", "and", "C0751837#ent", "<e1>", "changes", "of", "the", "lower", "extremities", "poorly", "coordinated", "gait", ",", "C3714552#ent", "<e2>", ",", "tetraspasticity", ",", "clumsiness", ",", "spasticity", ",", "hyperreflexia", ",", "and", "primitive", "reflexes"], "h": {"id": "C0751837", "name": "C0751837#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [19, 20]}}
{"token": ["There", "was", "no", "correlation", "between", "C3274822#ent", "<e1>", "and", "either", "blood", "pressure", "C1420877#ent", "<e2>", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420877", "name": "C1420877#ent", "pos": [11, 12]}}
{"token": ["A", "comparison", "of", "the", "predicted", "amino", "acid", "sequence", "C1412687#ent", "<e1>", "613", "with", "known", "C0073020#ent", "<e2>", "did", "not", "reveal", "any", "significant", "similarities", "."], "h": {"id": "C1412687", "name": "C1412687#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0073020", "name": "C0073020#ent", "pos": [13, 14]}}
{"token": ["We", "compared", "the", "health", "outcomes", "patients", "treated", "with", "C0663241#ent", "<e1>", "or", "vancomycin", "for", "complicated", "skin", "and", "C0149778#ent", "<e2>", "cSSTIs", ")", "."], "h": {"id": "C0663241", "name": "C0663241#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0149778", "name": "C0149778#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "the", "role", "of", "C-reactive", "protein", "response", "C1705930#ent", "<e1>", "in", "the", "risk", "of", "clinical", "restenosis", "new", "C0948480#ent", "<e2>", "considering", "C1705930#ent", "<e1>", "as", "a", "model", "to", "stimulate", "inflammation", "."], "h": {"id": "C1705930", "name": "C1705930#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0948480", "name": "C0948480#ent", "pos": [24, 25]}}
{"token": ["In", "conclusion", ",", "the", "present", "results", "suggest", "that", "C1705930#ent", "<e1>", "treatment", "of", "C0948480#ent", "<e2>", "C.", "pneumoniae", "the", "atherosclerotic", "lesions", "which", "leads", "to", "platelet", "activation", "lipid", "peroxidation"], "h": {"id": "C1705930", "name": "C1705930#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0948480", "name": "C0948480#ent", "pos": [12, 13]}}
{"token": ["However", ",", "Schild", "analysis", "indicated", "differences", "in", "the", "blockade", "and", "estimated", "pKb", "values", "with", "each", "C0243192#ent", "<e1>", "for", "both", "C0016971#ent", "<e2>", "and", "pirenzepine", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0016971", "name": "C0016971#ent", "pos": [19, 20]}}
{"token": ["Muscarine", "abolished", "the", "secretion", "induced", "by", "the", "C0243192#ent", "<e1>", ",", "this", "effect", "being", "prevented", "by", "atropine", "or", "C0016971#ent", "<e2>", ",", "but", "not", "by", "pirenzepine", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016971", "name": "C0016971#ent", "pos": [17, 18]}}
{"token": ["The", "Hill", "slopes", "the", "displacement", "curves", "near", "1", "for", "the", "antagonists", "and", "smaller", "than", "1", "for", "the", "C0243192#ent", "<e1>", "and", "for", "C0016971#ent", "<e2>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0016971", "name": "C0016971#ent", "pos": [21, 22]}}
{"token": ["This", "uncoupling", "phenomenon", "involves", "phosphorylation", "of", "beta", "AR", "at", "least", "two", "C0031727#ent", "<e1>", ",", "PKA", "and", "the", "C1312419#ent", "<e2>", "beta", "ARK", ",", "which", "are", "activated", "under", "different", "desensitizing", "conditions", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1312419", "name": "C1312419#ent", "pos": [17, 18]}}
{"token": ["By", "analogy", "with", "chemical", "models", "studies", "of", "C1366824#ent", "<e1>", "a", "mechanism", "is", "proposed", "for", "the", "reaction", "catalyzed", "by", "C0036725#ent", "<e2>"], "h": {"id": "C1366824", "name": "C1366824#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036725", "name": "C0036725#ent", "pos": [18, 19]}}
{"token": ["Three", "reactions", "are", "involved", "in", "methylenetetrahydrofolate", "recycling", ":", "C1366824#ent", "<e1>", "TS", ")", ",", "dihydrofolate", "reductase", "DHFR", ")", ",", "and", "C0036725#ent", "<e2>", "SHMT", ")", "."], "h": {"id": "C1366824", "name": "C1366824#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036725", "name": "C0036725#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "we", "have", "shown", "that", "D11597", "is", "physically", "linked", "to", "both", "D11S146", "and", "C1413172#ent", "<e1>", ",", "and", "is", "less", "than", "100", "kb", "C1427959#ent", "<e2>", "to", "the", "D115146", "."], "h": {"id": "C1413172", "name": "C1413172#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1427959", "name": "C1427959#ent", "pos": [24, 25]}}
{"token": ["These", "data", "demonstrate", "that", "DM", "greatly", "potentiates", "the", "C0728960#ent", "<e1>", "IB", ",", "DC", ",", "C1706141#ent", "<e2>", ",", "PIR", ",", "ET", ",", "and", "KT", "and", "increases", "the", "peak", "effect", "the", "NSAIDs", "alone", "."], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706141", "name": "C1706141#ent", "pos": [14, 15]}}
{"token": ["It", "is", "concluded", "that", "amplification", "of", "the", "cAMP", "response", "is", "able", "to", "unmask", "partial", "agonist", "activity", "C0055021#ent", "<e1>", "in", "the", "failing", "human", "heart", "at", "C1367657#ent", "<e2>"], "h": {"id": "C0055021", "name": "C0055021#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [24, 25]}}
{"token": ["It", "is", "concluded", "that", "C0055021#ent", "<e1>", "exerts", "a", "uniquely", "strong", "partial", "agonist", "activity", "C1367657#ent", "<e2>"], "h": {"id": "C0055021", "name": "C0055021#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [13, 14]}}
{"token": ["The", "responsiveness", "to", "inhaled", "salbutamol", "unaltered", "during", "the", "12-month", "trial", "period", ",", "demonstrating", "that", "C0055021#ent", "<e1>", "does", "not", "block", "the", "C1367657#ent", "<e2>", "bronchial", "smooth", "muscle"], "h": {"id": "C0055021", "name": "C0055021#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [20, 21]}}
{"token": ["C0004238#ent", "<e1>", "occurred", "in", "16", "(", "16", "%", ")", "of", "98", "C0037707#ent", "<e2>", "patients", "and", "in", "30", "(", "32", "%", ")", "of", "93", "metoprolol", "patients", "(", "p", "<", "0.01", ")", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0037707", "name": "C0037707#ent", "pos": [11, 12]}}
{"token": ["We", "present", "a", "case", "of", "a", "36-year-old", "woman", "with", "highly", "symptomatic", "persistent", "atrial", "fibrillation", "C0004238#ent", "<e1>", ")", "refractory", "to", "C0037707#ent", "<e2>", ",", "flecainide", ",", "and", "external", "direct", "current", "(", "DC", ")", "cardioversion", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [14, 15]}, "relation": "may_be_prevented_by", "t": {"id": "C0037707", "name": "C0037707#ent", "pos": [19, 20]}}
{"token": ["A", "variety", "of", "drugs", "effective", "against", "clinical", "C0004238#ent", "<e1>", ",", "including", "flecainide", ",", "propafenone", ",", "procainamide", ",", "and", "C0037707#ent", "<e2>", ",", "have", "been", "found", "to", "terminate", "experimental", "C0004238#ent", "<e1>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0037707", "name": "C0037707#ent", "pos": [18, 19]}}
{"token": ["RusA", "is", "a", "C0639056#ent", "<e1>", "by", "the", "C1332788#ent", "<e2>", "DLP12", "of", "Escherichia", "coli", "K-12", "can", "be", "activated", "to", "promote", "homologous", "recombination", "DNA", "repair", "resolution-deficient", "mutants", "lacking", "the", "RuvABC", "proteins", "."], "h": {"id": "C0639056", "name": "C0639056#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332788", "name": "C1332788#ent", "pos": [7, 8]}}
{"token": ["The", "enzyme", "activities", "were", "inhibited", "by", "two", "C0009871#ent", "<e1>", "gossypol", "and", "C0008286#ent", "<e2>", "."], "h": {"id": "C0009871", "name": "C0009871#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [11, 12]}}
{"token": ["This", "accounts", "for", "an", "inhibition", "of", "C0036572#ent", "<e1>", "by", "systemically", "administered", "GABA", "in", "C0268542#ent", "<e2>", "animals", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0268542", "name": "C0268542#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "may", "provide", "insights", "into", "the", "basic", "mechanisms", "of", "C0036572#ent", "<e1>", "observed", "in", "hepatic", "failure", "in", "other", "C0268542#ent", "<e2>", "states", ",", "and", "in", "epilepsy", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0268542", "name": "C0268542#ent", "pos": [18, 19]}}
{"token": ["An", "awareness", "of", "the", "clinical", "phenotype", "and", "of", "the", "electrodiagnostic", "and", "histopathologic", "features", "should", "lead", "to", "improved", "recognition", ",", "and", "should", "minimize", "confusion", "with", "C0011633#ent", "<e1>", ",", "motor", "neuron", "disease", "and", "other", "C0751950#ent", "<e2>"], "h": {"id": "C0011633", "name": "C0011633#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [32, 33]}}
{"token": ["The", "results", "suggest", "that", "pyrethroid", "insecticides", "C2936882#ent", "<e1>", "can", "enhance", "the", "expression", "of", "the", "C1421511#ent", "<e2>", "proto-oncogene", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421511", "name": "C1421511#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "down-regulation", "of", "C1420887#ent", "<e1>", "with", "small", "interfering", "RNAs", "enhanced", "CD40/CD40", "ligand-induced", "C1417708#ent", "<e2>", "showed", "no", "effect", "on", "TNF", "signaling", "."], "h": {"id": "C1420887", "name": "C1420887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [13, 14]}}
{"token": ["Phenytoin", "is", "often", "used", "to", "control", "status", "C0038220#ent", "<e1>", ",", "but", "its", "water-soluble", "prodrug", "C0244656#ent", "<e2>", ",", "may", "be", "more", "useful", "as", "it", "is", "easier", "to", "administer", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0244656", "name": "C0244656#ent", "pos": [14, 15]}}
{"token": ["Although", "C0022658#ent", "<e1>", "such", "as", "proteinuria", ",", "and", "C1565489#ent", "<e2>", "have", "been", "observed", "in", "half", "the", "cases", "of", "this", "syndrome", ",", "there", "have", "been", "few", "reports", "describing", "the", "renal", "lesions"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [8, 9]}}
{"token": ["In", "people", "with", "diabetes", ",", "C0022658#ent", "<e1>", "to", "progress", "from", "microalbuminuria", "to", "clinical", "proteinuria", "C1565489#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [14, 15]}}
{"token": ["Measurements", "of", "magnesium", "levels", "in", "blood", "and", "urine", "are", "justified", "when", "such", "abnormalities", "occur", "in", "patients", "with", "C0012242#ent", "<e1>", "predominantly", "alcoholism", ",", "C0023895#ent", "<e2>", "malabsorption", "."], "h": {"id": "C0012242", "name": "C0012242#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [22, 23]}}
{"token": ["In", "the", "past", "few", "years", ",", "a", "variety", "of", "C0012242#ent", "<e1>", "including", "cardiovascular", ",", "skin", ",", "rheumatic", "and", "C0023895#ent", "<e2>", "have", "been", "associated", "with", "Helicobacter", "pylori", "H.", "pylori", "infection", "."], "h": {"id": "C0012242", "name": "C0012242#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [18, 19]}}
{"token": ["This", "report", "summarizes", "an", "AASLD", "Clinical", "Workshop", "was", "presented", "at", "C0012242#ent", "<e1>", "Week", "2003", "on", "screening", "in", "C0023895#ent", "<e2>"], "h": {"id": "C0012242", "name": "C0012242#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [17, 18]}}
{"token": ["Protease", "inhibitors", "PIs", ")", ",", "particularly", "the", "C1706991#ent", "<e1>", "have", "proved", "to", "be", "powerful", "C3494348#ent", "<e2>", "of", "carcinogenesis", "in", "many", "in", "vitro", "animal", "model", "systems"], "h": {"id": "C1706991", "name": "C1706991#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [14, 15]}}
{"token": ["The", "accumulation", "of", "5HT", "20", "min", "following", "C0021171#ent", "<e1>", "injection", "of", "C0030557#ent", "<e2>", "was", "used", "as", "an", "index", "of", "5HT", "turnover", "."], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030557", "name": "C0030557#ent", "pos": [11, 12]}}
{"token": ["The", "development", "and", "extension", "of", "fundal", "gastritis", "intestinal", "metaplasia", "investigated", "by", "the", "endoscopic", "Congo", "red-methylene", "blue", "test", "in", "44", "healthy", "subjects", "106", "patients", "with", "C0038358#ent", "<e1>", "and", "26", "patients", "with", "C1333775#ent", "<e2>"], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1333775", "name": "C1333775#ent", "pos": [30, 31]}}
{"token": ["These", "data", "demonstrate", "the", "equality", "of", "C0052429#ent", "<e1>", "and", "quinine", "for", "severe", "C0024530#ent", "<e2>", "and", "indicate", "a", "trend", "toward", "greater", "effectiveness", "of", "C0052429#ent", "<e1>", "in", "regions", "where", "there", "is", "recognized", "quinine", "resistance", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0052429", "name": "C0052429#ent", "pos": [6, 7]}}
{"token": ["Thirty-three", "female", "patients", "suffering", "from", "acute", "uncomplicated", "falciparum", "C0024530#ent", "<e1>", "were", "treated", "with", "intramuscular", "C0052429#ent", "<e2>", "for", "5", "days", "during", "May-October", "1990", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0052429", "name": "C0052429#ent", "pos": [14, 15]}}
{"token": ["Cure", "followed", "therapy", "with", "antibiotic", "administration", "3", "days", "combined", "with", "C0039832#ent", "<e1>", "suggesting", "parasitic", "infection", "the", "most", "likely", "cause", "of", "C0025297#ent", "<e2>", "."], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [20, 21]}}
{"token": ["To", "understand", "how", "this", "factor", "is", "regulated", ",", "we", "characterized", "transgenic", "mice", "contain", "the", "C1704942#ent", "<e1>", "promoter", "linked", "to", "either", "C0005220#ent", "<e2>", "or", "green", "fluorescent", "protein", "GFP", ")", "reporters", "."], "h": {"id": "C1704942", "name": "C1704942#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [20, 21]}}
{"token": ["Several", "studies", "have", "shown", "that", "the", "stomach", "has", "sufficient", "C3659502#ent", "<e1>", "activity", "to", "metabolize", "a", "significant", "amount", "of", "alcohol", "and", "that", "C0008783#ent", "<e2>", "depresses", "this", "C3659502#ent", "<e1>", "activity", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [9, 10]}}
{"token": ["In", "vitro", "C0008783#ent", "<e1>", "was", "a", "noncompetitive", "inhibitor", "of", "C3659502#ent", "<e2>", "activity", "at", "concentrations", "as", "low", "as", "0.01", "mM", ",", "100-fold", "lower", "than", "those", "needed", "to", "inhibit", "the", "hepatic", "dehydrogenase"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [9, 10]}}
{"token": ["Nevertheless", ",", "C1430988#ent", "<e1>", "be", "absent", "in", "B-CLL", "with", "a", "normal", "C0694888#ent", "<e2>", "genotype", ",", "suggesting", "a", "role", "of", "this", "phosphatase", "in", "the", "molecular", "pathology", "B-CLL", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0694888", "name": "C0694888#ent", "pos": [11, 12]}}
{"token": ["The", "association", "of", "both", "proteins", "requires", "the", "N-terminal", "domain", "of", "C3539531#ent", "<e1>", "and", "the", "C0026900#ent", "<e2>", "TRF2", "."], "h": {"id": "C3539531", "name": "C3539531#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026900", "name": "C0026900#ent", "pos": [14, 15]}}
{"token": ["The", "Kd", "values", "are", "comparable", "to", "those", "(", "approximately", "10(-9", ")", "M", ")", "of", "other", "C1424659#ent", "<e1>", "peptides", ",", "demonstrating", "a", "tight", "binding", "of", "CaM", "by", "C1706599#ent", "<e2>", "."], "h": {"id": "C1424659", "name": "C1424659#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1706599", "name": "C1706599#ent", "pos": [26, 27]}}
{"token": ["Therefore", ",", "we", "investigated", "the", "effects", "of", "natural", "menopause", "endogenous", "sex", "steroids", "triglycerides", "(", "C1420709#ent", "<e1>", ")", ",", "a", "major", "risk", "factor", "C0007222#ent", "<e2>", "women", "."], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [22, 23]}}
{"token": ["These", "findings", "indicate", "that", "APOAV", "is", "an", "important", "determinant", "of", "plasma", "C1420709#ent", "<e1>", "and", "lipoprotein", "cholesterol", "and", "is", "potentially", "a", "risk", "factor", "C0007222#ent", "<e2>"], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [22, 23]}}
{"token": ["Our", "study", "shows", "that", "C0033228#ent", "<e1>", "may", "improve", "CP-induced", "acute", "renal", "failure", "to", "both", "peroxisome", "proliferation", "increased", "C1706127#ent", "<e2>", "in", "the", "cytosol", "of", "the", "proximal", "tubule"], "h": {"id": "C0033228", "name": "C0033228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706127", "name": "C1706127#ent", "pos": [17, 18]}}
{"token": ["In", "their", "stimulatory", "action", "the", "two", "PMN", "proteinases", "thus", "resemble", "the", "classic", "B-cell", "C2697656#ent", "<e1>", "and", "neutral", "pancreatic", "proteinases", "such", "as", "C0041236#ent", "<e2>", ",", "chymotrypsin", ",", "and", "elastase", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", "the", "effects", "of", "platelet", "poor", "plasma", "serum", "C2697656#ent", "<e1>", ")", "on", "the", "in-vitro", "spreading", "of", "C0041236#ent", "<e2>", "procine", "aortic", "endothelial", "cells", "EC", ")", "was", "investigated", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [18, 19]}}
{"token": ["Forty-three", "(", "21", "C0065374#ent", "<e1>", "and", "22", "atenolol", ")", "hypertensive", "NIDDM", "patients", "with", "C0011881#ent", "<e2>", "enrolled", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [13, 14]}}
{"token": ["To", "study", "the", "effects", "of", "angiotensin", "converting", "enzyme", "inhibitor", "C0065374#ent", "<e1>", ",", "on", "renal", "function", "incipient", "C0011881#ent", "<e2>", "a", "prospective", "double-blind", "randomised", "placebo-controlled", "single", "centre", "study", "was", "set", "up", "at", "our", "outpatient", "diabetic-renal", "clinic", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [9, 10]}, "relation": "may_prevent", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [16, 17]}}
{"token": ["Gardner's", "syndrome", "an", "C3899989#ent", "<e1>", "caused", "by", "mutations", "in", "APC", "(", "adenomatous", "polyposis", "coli", "C0017337#ent", "<e2>", ",", "which", "is", "located", "in", "chromosomal", "locus", "5q21-", "q22", "."], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["In", "urothelium", ",", "nitric", "oxide", "NO", ")", "produced", "by", "C1538973#ent", "<e1>", "NOS", ")", "plays", "various", "roles", "during", "C0012634#ent", "<e2>"], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [17, 18]}}
{"token": ["The", "functional", "role", "of", "the", "C1538973#ent", "<e1>", "NOS", ")", "isoforms", "in", "the", "normal", "or", "C0012634#ent", "<e2>", "kidney", "is", "uncertain", "."], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["Limb", "girdle", "muscular", "dystrophy", "type", "2B", "LGMD2B", ")", "and", "Miyoshi", "myopathy", "MM", ")", ",", "a", "C0751336#ent", "<e1>", "are", "both", "caused", "by", "mutations", "in", "the", "recently", "cloned", "C1414209#ent", "<e2>", "gene", "symbol", "DYSF", "."], "h": {"id": "C0751336", "name": "C0751336#ent", "pos": [15, 16]}, "relation": "disease_has_associated_gene", "t": {"id": "C1414209", "name": "C1414209#ent", "pos": [26, 27]}}
{"token": ["Time-relationship", "studies", "of", "this", "phenomenon", "show", "that", "CGRP-li", "and", "SP-li", "were", "decreased", "concomitantly", "to", "the", "formation", "of", "C0030920#ent", "<e1>", "the", "administration", "of", "C0010648#ent", "<e2>", "(", "900", "mg/kg", "p.o", ".", ")", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010648", "name": "C0010648#ent", "pos": [22, 23]}}
{"token": ["Astroglial", "cells", "transcribed", "the", "C0042720#ent", "<e1>", "high", "levels", "of", "C1413246#ent", "<e2>", "infectious", "virions", "peaked", "two", "to", "three", "days", "posttransfection", "."], "h": {"id": "C0042720", "name": "C0042720#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413246", "name": "C1413246#ent", "pos": [9, 10]}}
{"token": ["Direct", "virological", "diagnosis", "mainly", "based", "on", "molecular", "tools", "C0042720#ent", "<e1>", "amplification", "with", "specific", "primers", "and", "nucleic", "probes", "C1413246#ent", "<e2>", "antigenemia", "detection", ",", "and", "more", "rarely", "viral", "culture"], "h": {"id": "C0042720", "name": "C0042720#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413246", "name": "C1413246#ent", "pos": [17, 18]}}
{"token": ["C1332411#ent", "<e1>", "NBK", ")", ",", "also", "known", "as", "Bcl-2-interacting", "killer", "C1332411#ent", "<e1>", ")", ",", "is", "a", "death-promoting", "Bcl-2", "family", "protein", "with", "Bcl-2", "only", "the", "Bcl", "homology", "3", "BH3", ")", "domain", "."], "h": {"id": "C1332411", "name": "C1332411#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332411", "name": "C1332411#ent", "pos": [0, 1]}}
{"token": ["Natural", "born", "killer", "C1332411#ent", "<e1>", ")", ",", "also", "known", "as", "C1332411#ent", "<e1>", "BIK", ")", ",", "is", "a", "death-promoting", "Bcl-2", "family", "protein", "with", "Bcl-2", "only", "the", "Bcl", "homology", "3", "BH3", ")", "domain", "."], "h": {"id": "C1332411", "name": "C1332411#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332411", "name": "C1332411#ent", "pos": [3, 4]}}
{"token": ["Using", "two", "different", "protocols", "of", "allergen", "challenge", "we", "demonstrate", "that", "absence", "of", "C1332702#ent", "<e1>", "does", "not", "affect", "the", "development", "of", "C0034068#ent", "<e2>", "Th2", "cytokine", "responses"], "h": {"id": "C1332702", "name": "C1332702#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0034068", "name": "C0034068#ent", "pos": [20, 21]}}
{"token": ["Patients", "with", "prolactin-secreting", "pituitary", "tumours", "a", "diminished", "prolactin", "(", "PRL", ")", "response", "after", "administration", "of", "a", "variety", "of", "stimulatory", "agents", "including", "C1421143#ent", "<e1>", "TRH", ")", ",", "chlorpromazine", "(", "CPZ", ")", "and", "C1864904#ent", "<e2>"], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1864904", "name": "C1864904#ent", "pos": [31, 32]}}
{"token": ["These", "results", "demonstrate", "that", "C1421143#ent", "<e1>", "effectively", "inhibits", "the", "atropine-resistant", "stimulation", "of", "the", "gastric", "motility", "C1864904#ent", "<e2>", "also", "has", "potent", "relaxing", "effects", "on", "the", "muscular", "tonus", "the", "gastric", "wall"], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1864904", "name": "C1864904#ent", "pos": [15, 16]}}
{"token": ["An", "RNA", "synthesis", "inhibitor", ",", "actinomycin", "D", "2", "microg/mL", ")", ",", "inhibited", "C3273763#ent", "<e1>", "expression", "of", "C1415012#ent", "<e2>"], "h": {"id": "C3273763", "name": "C3273763#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415012", "name": "C1415012#ent", "pos": [16, 17]}}
{"token": ["Decreased", "levels", "(", "about", "30", "%", ")", "of", "particulate", "puromycin-insensitive-neutral", "aminopeptidase", "the", "renal", "medulla", "of", "C0002570#ent", "<e1>", "the", "lung", "were", "observed", "under", "C0268009#ent", "<e2>", "and", "hypovolemia", "."], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0268009", "name": "C0268009#ent", "pos": [22, 23]}}
{"token": ["Although", "several", "C0035064#ent", "<e1>", "are", "available", "to", "treat", "C1414863#ent", "<e2>", ",", "they", "occasionally", "fail", "to", "abort", "seizure", "activity"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [8, 9]}}
{"token": ["Finally", ",", "specific", "extracellular", "matrix", "ECM", ")", "C0086376#ent", "<e1>", "were", "able", "to", "regulate", "the", "expression", "of", "C1413930#ent", "<e2>", "at", "the", "mRNA", "level", "in", "a", "slightly", "different", "manner", "than", "previously", "observed", "for", "biglycan", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413930", "name": "C1413930#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "effect", "of", "IL-10", "on", "gene", "expression", "extracellular", "matrix", "ECM", ")", "C0086376#ent", "<e1>", ",", "such", "as", "type", "I", "collagen", "fibronectin", ",", "and", "C1413930#ent", "<e2>", ",", "in", "human", "skin", "fibroblasts", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413930", "name": "C1413930#ent", "pos": [28, 29]}}
{"token": ["The", "stroma", "is", "the", "supportive", "framework", "biologic", "tissue", "the", "breast", ",", "consisting", "of", "various", "C0086376#ent", "<e1>", "such", "as", "the", "proteoglycans", ",", "C1413930#ent", "<e2>", "and", "lumican", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413930", "name": "C1413930#ent", "pos": [21, 22]}}
{"token": ["Peripheral", "T", "cells", "3", "Lesch-Nyhan", "patients", ",", "3", "normal", "subjects", "and", "3", "brothers", "with", "C0023374#ent", "<e1>", "HGPRT", ")", "deficiency", "but", "without", "C1415701#ent", "<e2>", "so-called", "partial", "deficiency", "have", "been", "analyzed", "."], "h": {"id": "C0023374", "name": "C0023374#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1415701", "name": "C1415701#ent", "pos": [21, 22]}}
{"token": ["We", "found", "that", "C1740167#ent", "<e1>", "is", "identical", "to", "the", "transmembrane", "isoform", "of", "prostatic", "acid", "phosphatase", "C1367456#ent", "<e2>", ")", ",", "an", "enzyme", "with", "unknown", "molecular", "and", "physiological", "functions"], "h": {"id": "C1740167", "name": "C1740167#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1367456", "name": "C1367456#ent", "pos": [15, 16]}}
{"token": ["We", "thus", "conducted", "a", "study", "on", "adult", "patients", "with", "bronchial", "asthma", "C0024117#ent", "<e1>", "treated", "with", "theophylline", "and", "injectable", "C3536939#ent", "<e2>", "in", "Japan", "in", "order", "to", "assess", "the", "safety", "of", "these", "drugs", "."], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3536939", "name": "C3536939#ent", "pos": [18, 19]}}
{"token": ["In", "addition", "we", "show", "that", "IL-1", ",", "IL-6", "and", "TNF-alpha", "are", "important", "C0127400#ent", "<e1>", "of", "changes", "in", "C1419798#ent", "<e2>", "concentrations", "induced", "by", "AS101", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419798", "name": "C1419798#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "PLC-gamma1", "activation", "plays", "pivotal", "and", "pleiotropic", "roles", "the", "stimulation", "of", "C1705753#ent", "<e1>", ",", "whereas", "activation", "of", "C2713509#ent", "<e2>", "negatively", "modulates", "this", "response", "in", "Jurkat", "T", "cells"], "h": {"id": "C1705753", "name": "C1705753#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [20, 21]}}
{"token": ["C0015674#ent", "<e1>", "enabled", "us", "to", "validate", "directly", "the", "cellular", "dependency", "C0524928#ent", "<e2>", "sources", "and", "changes", "in", "biomolecules", "produced", "according", "to", "alterations", "in", "the", "cellular", "energetic", "status", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [10, 11]}}
{"token": ["The", "prognosis", ",", "in", "terms", "of", "later", "intelligence", ",", "epilepsy", "and", "behavioural", "problems", "was", "worse", "than", "in", "those", "with", "'", "idiopathic", "'", "C0037769#ent", "<e1>", "in", "those", "with", "simultaneous", "C0027765#ent", "<e2>"], "h": {"id": "C0037769", "name": "C0037769#ent", "pos": [22, 23]}, "relation": "has_nichd_parent", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [28, 29]}}
{"token": ["It", "is", "suggested", "that", "the", "low", "dose", "stimulatory", "effects", "related", "to", "actions", "at", "C1846414#ent", "<e1>", "whereas", "the", "high", "dose", "C0007681#ent", "<e2>", "effects", "are", "related", ",", "at", "least", "in", "part", ",", "to", "activation", "of", "gamma-aminobutyric", "acid-A", "receptors"], "h": {"id": "C1846414", "name": "C1846414#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [19, 20]}}
{"token": ["However", ",", "more", "children", "with", "C0035869#ent", "<e1>", "vomited", "and", "C0011991#ent", "<e2>", "significantly", "longer", "(", "14.9", "days", ")", "than", "rotavirus", "diarrhoea", "5.9", "days", ")", "."], "h": {"id": "C0035869", "name": "C0035869#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [9, 10]}}
{"token": ["RT-PCR", "was", "employed", "to", "detect", "C0035869#ent", "<e1>", "450", "fecal", "samples", "from", "children", "with", "C0011991#ent", "<e2>"], "h": {"id": "C0035869", "name": "C0035869#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [13, 14]}}
{"token": ["An", "epidemiological", "survey", "investigating", "the", "prevalence", "of", "C0035869#ent", "<e1>", "infants", "and", "young", "children", "with", "C0011991#ent", "<e2>", "undertaken", "in", "Jos", "State", ",", "Nigeria", ",", "between", "January", "1998", "and", "April", "1999", "."], "h": {"id": "C0035869", "name": "C0035869#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [14, 15]}}
{"token": ["The", "clinical", "picture", "from", "the", "classic", "form", "of", "C0014921#ent", "<e1>", "in", "that", "the", "C0041834#ent", "<e2>", "began", "on", "the", "scalp", "and", "spread", "to", "the", "extremities", ",", "progressing", "in", "three", "cases", "to", "extensive", "bullous", "formation"], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", "Fas", "and", "C1539478#ent", "<e1>", "expressed", "in", "ducts", "and", "acini", "of", "C0037023#ent", "<e2>", "SS", "patients", "induce", "apoptosis", ",", "possibily", "in", "an", "autocrine", "and/or", "paracrine", "manner", "."], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037023", "name": "C0037023#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "the", "upper", "gastrointestinal", "(GI", "tolerability", "of", "C0538927#ent", "<e1>", ",", "naproxen", ",", "and", "placebo", "in", "patients", "with", "C0038013#ent", "<e2>", "RA", ")", "and", "osteoarthritis", "(", "OA", ")", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [18, 19]}}
{"token": ["To", "evaluate", "the", "short-term", "efficacy", "of", "C0538927#ent", "<e1>", ",", "a", "cyclooxygenase", "2-specific", "inhibitor", "in", "the", "treatment", "of", "C0038013#ent", "<e2>", "AS", ")", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [17, 18]}}
{"token": ["We", "show", "that", "C1418938#ent", "<e1>", "induces", "an", "increase", "in", "the", "c-Jun", "content", "of", "C0162508#ent", "<e2>", "transcriptional", "complexes", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [13, 14]}}
{"token": ["In", "other", "reports", ",", "C0141185#ent", "<e1>", "refers", "to", "the", "mouse", "enzyme", "encoded", "by", "the", "C1419253#ent", "<e2>", ",", "which", "is", "structurally", "and", "functionally", "homologous", "to", "RLIP76", ",", "the", "human", "protein", "encoded", "by", "the", "human", "RALBP1", "gene"], "h": {"id": "C0141185", "name": "C0141185#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419253", "name": "C1419253#ent", "pos": [14, 15]}}
{"token": ["In", "other", "reports", ",", "Ralbp1", "refers", "to", "the", "mouse", "enzyme", "encoded", "by", "the", "C0141185#ent", "<e1>", ",", "which", "is", "structurally", "and", "functionally", "homologous", "to", "C1419253#ent", "<e2>", ",", "the", "human", "protein", "encoded", "by", "the", "human", "RALBP1", "gene"], "h": {"id": "C0141185", "name": "C0141185#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419253", "name": "C1419253#ent", "pos": [23, 24]}}
{"token": ["The", "present", "study", "reports", "gender", "related", "differences", "in", "ATP-dependent", "transport", "of", "C0141185#ent", "<e1>", "(", "GSH", ")", "conjugate", "(", "C1419253#ent", "<e2>", ")", ",", "a", "model", "GSH", "xenobiotic", "conjugate", "across", "murine", "canalicular", "liver", "plasma", "membrane", "cLPM", ")", "."], "h": {"id": "C0141185", "name": "C0141185#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419253", "name": "C1419253#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "describe", "microplate", "assays", "for", "determining", "the", "specific", "activities", "of", "four", "enzymes", "that", "constitute", "the", "ascorbate-glutathione", "cycle", "C1332102#ent", "<e1>", ",", "MDHAR", ",", "DHAR", ",", "and", "C1705401#ent", "<e2>", "."], "h": {"id": "C1332102", "name": "C1332102#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [27, 28]}}
{"token": ["The", "model", "consists", "of", "kinetic", "equations", "the", "intracellular", "variation", "of", "17", "compounds", ",", "including", "C1704838#ent", "<e1>", ",", "iron", ",", "prolyl", "hydroxylase", "oxygen", ",", "ascorbate", ",", "C1291208#ent", "<e2>", ",", "von", "Hippel", "Lindau", "protein", "associated", "complexes"], "h": {"id": "C1704838", "name": "C1704838#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1291208", "name": "C1291208#ent", "pos": [25, 26]}}
{"token": ["Lck", "and", "C1442788#ent", "<e1>", "in", "the", "C1428877#ent", "<e2>", "did", "not", "increase", "after", "mitogen", "(", "concanavalin", "A", "concanavalin", "A", "plus", "phorbol", "ester", ")", "stimulation", "of", "the", "cells", ",", "in", "contrast", "to", "control", "T", "cells"], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1428877", "name": "C1428877#ent", "pos": [6, 7]}}
{"token": ["Practically", ",", "C0029442#ent", "<e1>", "of", "digestive", "origin", "results", "from", "C0376286#ent", "<e2>"], "h": {"id": "C0029442", "name": "C0029442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0376286", "name": "C0376286#ent", "pos": [9, 10]}}
{"token": ["Agonists", "of", "both", "C2984537#ent", "<e1>", "(", "WY14,643", "and", "gemfibrozil", ")", "and", "PPARbeta", "(", "C0005330#ent", "<e2>", ")", "induced", "luciferase", "activity", "while", "rosiglitazone", ",", "a", "PPARgamma", "agonist", "was", "not", "effective", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005330", "name": "C0005330#ent", "pos": [13, 14]}}
{"token": ["This", "was", "mimicked", "by", "feeding", "with", "agonists", "for", "peroxisome", "proliferator-activated", "receptor", "alpha", "C2984537#ent", "<e1>", ")", "such", "as", "fenofibrate", "and", "C0005330#ent", "<e2>", ",", "but", "not", "the", "PPARgamma", "agonist", "troglitazone", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0005330", "name": "C0005330#ent", "pos": [19, 20]}}
{"token": ["While", "fenofibrate", "and", "LY518674", "showed", "exclusive", "dependency", "on", "C2984537#ent", "<e1>", "for", "these", "activities", ",", "C0005330#ent", "<e2>", "and", "gemfibrozil", "exhibited", "dependency", "on", "PPARbeta/delta", "and", "PPARgamma", "as", "well", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005330", "name": "C0005330#ent", "pos": [14, 15]}}
{"token": ["In", "mouse", "fibroblasts", "stimulated", "from", "quiescence", "into", "proliferation", "by", "serum", "the", "induction", "of", "expression", "of", "the", "C0086661#ent", "<e1>", "proto-oncogene", "is", "strongly", "stimulated", "by", "C0047550#ent", "<e2>", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0047550", "name": "C0047550#ent", "pos": [23, 24]}}
{"token": ["However", ",", "since", "RA", "and", "C0022408#ent", "<e1>", "due", "to", "a", "C0007302#ent", "<e2>", "both", "may", "create", "a", "similar", "macroscopic", "(", "and", "thus", "radiological", ")", "eburnation", "topography", "."], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0007302", "name": "C0007302#ent", "pos": [10, 11]}}
{"token": ["The", "inhibitory", "effect", "of", "mutant", "PTP1C", "was", "overcome", "by", "cotransfection", "with", "C2987364#ent", "<e1>", "PTP1C", ",", "but", "not", "with", "the", "structurally", "related", "C1335280#ent", "<e2>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335280", "name": "C1335280#ent", "pos": [21, 22]}}
{"token": ["C1333571#ent", "<e1>", "activity", "was", "increased", ",", "whereas", "glucocorticoid", "response", "element", "polyoma", "enhancer", "activator", "3", "and", "nuclear", "factor", "kappa", "B", "C0812382#ent", "<e2>", "not", "changed", "significantly", "."], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggested", "that", "the", "abnormal", "activation", "of", "NF-kappaB", "and", "C1333571#ent", "<e1>", "and", "the", "reduction", "of", "GR", "C0812382#ent", "<e2>", "abilities", "may", "be", "involved", "in", "the", "pathogenesis", "of", "MCNS", "."], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [17, 18]}}
{"token": ["At", "atiaggressive", "doses", "C3540800#ent", "<e1>", "did", "not", "produce", "C0007758#ent", "<e2>", "as", "measured", "by", "the", "inclined-screen", "or", "rotarod", "procedures", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [8, 9]}}
{"token": ["Here", "5", "cases", "are", "presented", "in", "which", "the", "combination", "of", "clonazepam", "(", "2", "mg-16", "mg", ")", "plus", "C3540800#ent", "<e1>", "(", "900", "mg-2400", "mg", ")", "produced", "a", "neurotoxic", "syndrome", "C0007758#ent", "<e2>", "and", "dysarthria", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [28, 29]}}
{"token": ["Importantly", ",", "C1826545#ent", "<e1>", "releases", "from", "purified", "chromatin", "in", "vitro", "conditions", "where", "H2A", "and", "C1426975#ent", "<e2>", "remain", "associated", "."], "h": {"id": "C1826545", "name": "C1826545#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426975", "name": "C1426975#ent", "pos": [14, 15]}}
{"token": ["In", "addition", "to", "LAT", ",", "C0136864#ent", "<e1>", "GEM", "recruitment", "depended", "on", "C1705639#ent", "<e2>", ",", "and", ",", "in", "particular", ",", "required", "the", "Gads-binding", "domain", "of", "C1705639#ent", "<e2>", "."], "h": {"id": "C0136864", "name": "C0136864#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705639", "name": "C1705639#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "treatment", "of", "SLP-76-deficient", "platelets", "with", "collagen", "fails", "to", "elicit", "tyrosine", "phosphorylation", "C0136864#ent", "<e1>", "PLC-gamma2", ")", ",", "suggesting", "that", "C1705639#ent", "<e2>", "functions", "upstream", "of", "PLC-gamma2", "activation"], "h": {"id": "C0136864", "name": "C0136864#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705639", "name": "C1705639#ent", "pos": [20, 21]}}
{"token": ["Recent", "evidence", "suggests", "that", "C0271814#ent", "<e1>", "an", "autoimmune", "disease", "by", "lymphocytic", "infiltration", "the", "thyroid", "and", "by", "C3831153#ent", "<e2>", "followed", "occasionally", "by", "transient", "hypothyroidism", "and", "eventual", "recovery", "."], "h": {"id": "C0271814", "name": "C0271814#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [16, 17]}}
{"token": ["Silent", "or", "C0271814#ent", "<e1>", "a", "frequent", "cause", "of", "C3831153#ent", "<e2>", "which", "is", "characterized", "by", "recent", "onset", "of", "symptoms", "in", "a", "patient", "with", "a", "normal", "to", "modestly", "enlarged", "and", "firm", "thyroid", "gland"], "h": {"id": "C0271814", "name": "C0271814#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [8, 9]}}
{"token": ["Public", "health", "clinical", "strategies", "for", "C0025289#ent", "<e1>", "epidemics", "in", "sub-Saharan", "Africa", "assume", "that", "C0025303#ent", "<e2>", "most", "disease", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0025303", "name": "C0025303#ent", "pos": [13, 14]}}
{"token": ["One", "possible", "reason", "for", "the", "lack", "of", "effectiveness", "might", "be", "neutralization", "of", "the", "C0013227#ent", "<e1>", "by", "host", "'s", "C3669283#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3669283", "name": "C3669283#ent", "pos": [18, 19]}}
{"token": ["After", "1", "h", ",", "biopsies", "were", "taken", "from", "a", "normal", "region", "the", "two", "ischemic", "regions", "were", "analyzed", "for", "C2744579#ent", "<e1>", ",", "phosphocreatine", "(", "PC", ")", ",", "and", "C0376261#ent", "<e2>"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [27, 28]}}
{"token": ["In", "quiescent", "rabbit", "papillary", "muscle", "20", "degrees", "C", ",", "the", "formation", "of", "C2744579#ent", "<e1>", "in", "nitrogen", ",", "estimated", "from", "the", "production", "of", "C0376261#ent", "<e2>", ",", "is", "21", "%", "of", "that", "in", "oxygen", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [22, 23]}}
{"token": ["We", "have", "generated", "a", "line", "of", "transgenic", "(", "C1420709#ent", "<e1>", ")", "mice", "with", "C3889744#ent", "<e2>", "driven", "by", "the", "simian", "virus", "early", "promoter", "."], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3889744", "name": "C3889744#ent", "pos": [13, 14]}}
{"token": ["C0054831#ent", "<e1>", ",", "a", "pyrazolopyridine", "that", "facilitated", "the", "binding", "of", "C1706331#ent", "<e2>", "to", "membrane-located", "and", "CHAPS-solubilized", "receptors", ",", "did", "not", "facilitate", "C1706331#ent", "<e2>", "binding", "to", "OCTG-solubilized", "receptors", "."], "h": {"id": "C0054831", "name": "C0054831#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [10, 11]}}
{"token": ["These", "C0086376#ent", "<e1>", "were", "radioiodinated", "and", "digested", "with", "C0764105#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0764105", "name": "C0764105#ent", "pos": [8, 9]}}
{"token": ["The", "binding", "of", "three", "closely", "related", "C0086376#ent", "<e1>", ",", "namely", "alpha-chymotrypsinogen", "A", "C0764105#ent", "<e2>", ",", "and", "C0764105#ent", "<e2>", "inactivated", "with", "diisopropyl", "fluorophosphate", "DIFP", ")", "to", "the", "affinity", "gel", "was", "investigated", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0764105", "name": "C0764105#ent", "pos": [12, 13]}}
{"token": ["From", "this", "substructure", ",", "we", "determine", "the", "percentage", "of", "alpha-helix", ",", "beta-sheet", ",", "and", "random", "coil", "the", "C0086376#ent", "<e1>", "lysozyme", ",", "albumin", ",", "ribonuclease", "A", "and", "C0764105#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0764105", "name": "C0764105#ent", "pos": [26, 27]}}
{"token": ["The", "reductions", "in", "L-kynurenine", "and", "quinolinic", "acid", "formation", "are", "consistent", "with", "reports", "that", "norharmane", "is", "an", "inhibitor", "of", "indoleamine", "2,3-dioxygenase", "6-chloro-DL-tryptophan", "is", "C0025517#ent", "<e1>", "through", "the", "kynurenine", "pathway", "and", "4-chloro-3-hydroxyanthranilate", "is", "an", "inhibitor", "of", "C1415456#ent", "<e2>"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1415456", "name": "C1415456#ent", "pos": [34, 35]}}
{"token": ["C1121259#ent", "<e1>", "and", "disadvantages", "of", "viral", "vectors", "C1520007#ent", "<e2>", "gene", "delivery", "digestive", "organs", "reviewed", "."], "h": {"id": "C1121259", "name": "C1121259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1520007", "name": "C1520007#ent", "pos": [7, 8]}}
{"token": ["The", "C1121259#ent", "<e1>", "and", "disadvantages", "of", "viral", "and", "C1520007#ent", "<e2>", "gene", "delivery", "reviewed", "."], "h": {"id": "C1121259", "name": "C1121259#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1520007", "name": "C1520007#ent", "pos": [8, 9]}}
{"token": ["When", "the", "inhibitory", "effect", "of", "C0030038#ent", "<e1>", "on", "transmitter", "release", "studied", ",", "pancuronium", ",", "C0031978#ent", "<e2>", "and", "atropine", "were", "competitive", "antagonists", "of", "presynaptic", "muscarinic", "receptors", "on", "the", "noradrenergic", "axon", "terminals", "the", "atrium", "."], "h": {"id": "C0030038", "name": "C0030038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [14, 15]}}
{"token": ["C0030038#ent", "<e1>", ",", "pilocarpine", ",", "and", "C0031978#ent", "<e2>", "each", "enhanced", "resting", "tonus", "and", "potentiated", "ACh-induced", "contractions", "(", "order", "of", "potency", ":", "pilocarpine", ">", "oxotremorine", "=", "C0031978#ent", "<e2>", ")", "."], "h": {"id": "C0030038", "name": "C0030038#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [6, 7]}}
{"token": ["Our", "data", "show", "that", "6", "beta-AN", "gallamine", ",", "C0030038#ent", "<e1>", "and", "carbachol", "are", "M2-R", "subtype", "selective", "agents", ",", "while", "C0031978#ent", "<e2>", "and", "pilocarpine", "are", "M1-R", "subtype", "selective", "agents", "."], "h": {"id": "C0030038", "name": "C0030038#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [19, 20]}}
{"token": ["Bardet-Biedl", "syndrome", "genetically", "heterogeneous", "with", "three", "cloned", "genes", "BBS2", ",", "BBS4", ",", "and", "C1417174#ent", "<e1>", ")", "and", "at", "least", "three", "other", "known", "loci", "(", "C1412746#ent", "<e2>", ",", "BBS3", ",", "and", "BBS5", ")", "."], "h": {"id": "C1417174", "name": "C1417174#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412746", "name": "C1412746#ent", "pos": [24, 25]}}
{"token": ["C0017168#ent", "<e1>", "GERD", ")", "can", "be", "associated", "with", "variety", "of", "C0014852#ent", "<e2>", "EED", ")", "such", "as", "chronic", "cough", "asthma", ",", "laryngeal", "disorder", "chest", "pain"], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0014852", "name": "C0014852#ent", "pos": [10, 11]}}
{"token": ["Rothmund-Thomson", "syndrome", "RTS", ")", "is", "a", "rare", "C3899988#ent", "<e1>", "is", "characterized", "by", "C0037285#ent", "<e2>", "juvenile", "cataracts", "and", "extracutaneous", "manifestations", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [12, 13]}}
{"token": ["The", "single-dose", "plasma", "kinetics", "of", "C0012228#ent", "<e1>", "was", "studied", "in", "healthy", "young", "old", "subjects", "in", "patients", "with", "C0003873#ent", "<e2>", "and", "in", "patients", "with", "renal", "failure"], "h": {"id": "C0012228", "name": "C0012228#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}}
{"token": ["Hypomorphic", "mutations", "which", "lead", "to", "decreased", "function", "of", "the", "C1705041#ent", "<e1>", "responsible", "for", "C0398791#ent", "<e2>", "a", "rare", "autosomal", "recessive", "hereditary", "disorder", "imparts", "an", "increased", "predisposition", "to", "development", "of", "malignancy", "."], "h": {"id": "C1705041", "name": "C1705041#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0398791", "name": "C0398791#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "C0021246#ent", "<e1>", ",", "and", "potentially", "other", "C0003211#ent", "<e2>", "may", "be", "used", "in", "conjunction", "with", "a", "tendon", "injury", "significantly", "affecting", "the", "early", "healing", "process", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [4, 5]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}}
{"token": ["Exposure", "of", "to", "C0021246#ent", "<e1>", ",", "a", "commonly", "used", "C0003211#ent", "<e2>", ",", "induced", "GRP78", "as", "well", "as", "CHOP", ",", "a", "transcription", "factor", "in", "apoptosis", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [3, 4]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [9, 10]}}
{"token": ["C0040822#ent", "<e1>", "can", "be", "differentiated", "from", "most", "other", "C0026650#ent", "<e2>", "are", "further", "classified", "according", "to", "their", "frequency", ",", "and", "whether", "they", "are", "present", "at", "rest", "or", "with", "action", "."], "h": {"id": "C0040822", "name": "C0040822#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [8, 9]}}
{"token": ["Amyloid", "fibrils", "such", "as", "those", "found", "in", "Alzheimer's", "the", "C0002726#ent", "<e1>", "result", "from", "the", "misassembly", "of", "C0030956#ent", "<e2>", "produced", "by", "either", "normal", "or", "aberrant", "intracellular", "proteolytic", "processing"], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}}
{"token": ["Although", "renal", "biopsy", "a", "C4288921#ent", "<e1>", "the", "clinical", "picture", "more", "compatible", "with", "minimal", "C0268731#ent", "<e2>"], "h": {"id": "C4288921", "name": "C4288921#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [13, 14]}}
{"token": ["The", "80", "and", "120", "mg/kg", "treated", "monkeys", "did", "not", "excrete", "feces", "until", "24", "h", "from", "administration", "of", "C0002600#ent", "<e1>", ",", "and", "also", "showed", "prolonged", "crouching", "and", "C0023380#ent", "<e2>", "."], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [26, 27]}}
{"token": ["In", "fact", ",", "recent", "and", "ongoing", "clinical", "trials", "C0018802#ent", "<e1>", "diabetic", "nephropathy", "first", "beneficial", "effects", "of", "C1879678#ent", "<e2>", "in", "these", "conditions", "(", "reduction", "of", "urinary", "albumin/creatinine-ratio", "and", "NTproBNP", ",", "respectively", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1879678", "name": "C1879678#ent", "pos": [16, 17]}}
{"token": ["Dynamic", "postpartum", "C3273356#ent", "<e1>", "secretion", "is", "in", "response", "to", "the", "C1417685#ent", "<e2>", "stimulus", "of", "suckling", ",", "which", "both", "acutely", "releases", "C3273356#ent", "<e1>", "and", "maintains", "the", "responsiveness", "of", "C3273356#ent", "<e1>", "regulatory", "pathways", "subsequent", "nursing", "."], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417685", "name": "C1417685#ent", "pos": [10, 11]}}
{"token": ["Amyloid", "plaques", "are", "encountered", "in", "all", "cases", "of", "kuru", "and", "Gerstmann-Straussler-Scheinker", "disease", "C2347435#ent", "<e1>", ")", "and", "in", "some", "10", "-", "15", "%", "of", "C0022336#ent", "<e2>", "sCJD", ")", "cases", "."], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [23, 24]}}
{"token": ["Creutzfeldt-Jakob", "disease", "C2347435#ent", "<e1>", ")", "is", "a", "rare", "fatal", "dementia", "caused", "by", "a", "C0022336#ent", "<e2>"], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [13, 14]}}
{"token": ["Prion", "protein", "PrP", ")", "amyloid", "formation", "a", "central", "feature", "of", "genetic", "and", "acquired", "forms", "of", "prion", "disease", "as", "Gerstmann-Str\u00e4ussler-Scheinker", "disease", "C2347435#ent", "<e1>", ")", "and", "variant", "C0022336#ent", "<e2>"], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [20, 21]}, "relation": "gene_associated_with_disease", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [25, 26]}}
{"token": ["C4060038#ent", "<e1>", "TNSALP", ")", "in", "serum", "comprises", "liver", "alkaline", "phosphatase", "liver-ALP", ")", "and", "C0002059#ent", "<e2>", "bone-ALP", ")", "."], "h": {"id": "C4060038", "name": "C4060038#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0002059", "name": "C0002059#ent", "pos": [13, 14]}}
{"token": ["C0007273#ent", "<e1>", "a", "frequent", "cause", "of", "transient", "C0007787#ent", "<e2>", "of", "cerebral", "infarction"], "h": {"id": "C0007273", "name": "C0007273#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [7, 8]}}
{"token": ["We", "examined", "the", "role", "of", "target", "of", "rapamycin", "(", "TOR", ")", ",", "a", "highly", "conserved", "C0033640#ent", "<e1>", "cell", "growth", "as", "a", "physiological", "target", "of", "EGAP", "C0124604#ent", "<e2>", "acetylation", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [25, 26]}}
{"token": ["A", "chimeric", "construct", "in", "which", "the", "C3537332#ent", "<e1>", "rice", "RPA1", "spliced", "into", "the", "corresponding", "region", "of", "C1419618#ent", "<e2>", "was", "able", "to", "complement", "a", "yeast", "rpa1", "mutant", "."], "h": {"id": "C3537332", "name": "C3537332#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419618", "name": "C1419618#ent", "pos": [16, 17]}}
{"token": ["The", "trimeric", "human", "C3537332#ent", "<e1>", "HSSB", ";", "also", "called", "C1419618#ent", "<e2>", ")", "plays", "an", "essential", "role", "in", "DNA", "replication", "nucleotide", "excision", "repair", "and", "homologous", "DNA", "recombination"], "h": {"id": "C3537332", "name": "C3537332#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419618", "name": "C1419618#ent", "pos": [9, 10]}}
{"token": ["We", "hypothesize", "that", "the", "differences", "in", "pulmonary", "C1537986#ent", "<e1>", "environment", "caused", "by", "either", "inspiratory", "C1537986#ent", "<e1>", "loading", "or", "fluctuations", "in", "venous", "C1537986#ent", "<e1>", "concentration", "act", "differently", "on", "the", "C1416867#ent", "<e1>", "."], "h": {"id": "C1537986", "name": "C1537986#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [28, 29]}}
{"token": ["ln(PICO2", ")", "]", "is", "a", "more", "appropriate", "measure", "of", "the", "typical", "C1537986#ent", "<e1>", "sensitivity", "of", "C1416867#ent", "<e2>", "in", "burrowing", "owls"], "h": {"id": "C1537986", "name": "C1537986#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [15, 16]}}
{"token": ["We", "demonstrate", "that", "the", "cytogenetically", "defined", "translocation", "t(X;1)(p11.2;p34", ")", "observed", "in", "papillary", "renal", "cell", "carcinomas", "results", "in", "the", "fusion", "of", "the", "C1419989#ent", "<e1>", "PSF", "located", "at", "1p34", "to", "the", "C1420632#ent", "<e2>", "Xp11.2", "."], "h": {"id": "C1419989", "name": "C1419989#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [29, 30]}}
{"token": ["Pre-treatment", "with", "C0012694#ent", "<e1>", "inhibits", "the", "C0006266#ent", "<e2>", "in", "a", "dose", "related", "manner", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [6, 7]}}
{"token": ["The", "protective", "effect", "DSCG", "(", "C0012694#ent", "<e1>", "was", "tested", "in", "23", "patients", "with", "C0006266#ent", "<e2>", "induced", "by", "specific", "allergen", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [13, 14]}}
{"token": ["C0012694#ent", "<e1>", "given", "before", "or", "after", "atropine", ",", "had", "no", "effect", "the", "C0006266#ent", "<e2>", "and", "cardiovascular", "responses", "unilateral", "or", "bilateral", "stimulation", "of", "the", "vagus", "nerves"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [12, 13]}}
{"token": ["The", "importance", "of", "P-glycoprotein", "(", "P-gp", ")", "in", "the", "pharmacokinetics", "of", "C0103045#ent", "<e1>", "and", "the", "effects", "of", "P-gp", "inhibitor", "cyclosporine", "A", "C0010592#ent", "<e2>", ")", "was", "investigated", "both", ",", "in", "vitro", "in", "vivo"], "h": {"id": "C0103045", "name": "C0103045#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [21, 22]}}
{"token": ["The", "nisin", "Z", "biosynthetic", "genes", "highly", "similar", "with", "the", "C1417679#ent", "<e1>", "of", "the", "C0028115#ent", "<e2>", "operons", "having", ",", "however", ",", "a", "0", "-", "3", "%", "difference", "in", "the", "amino", "acid", "sequences", "the", "individual", "proteins"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028115", "name": "C0028115#ent", "pos": [13, 14]}}
{"token": ["C0138837#ent", "<e1>", "FTase", ")", "is", "a", "C0596918#ent", "<e2>", "catalyzes", "the", "addition", "of", "a", "farnesyl", "isoprenoid", "to", "a", "conserved", "cysteine", "in", "peptide", "or", "protein", "substrates", "."], "h": {"id": "C0138837", "name": "C0138837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0596918", "name": "C0596918#ent", "pos": [6, 7]}}
{"token": ["As", "has", "been", "reported", "for", "the", "C0138837#ent", "<e1>", "the", "yeast", "type", "I", "protein", "geranylgeranyltransferase", "also", "a", "magnesium-requiring", ",", "C0596918#ent", "<e2>"], "h": {"id": "C0138837", "name": "C0138837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0596918", "name": "C0596918#ent", "pos": [18, 19]}}
{"token": ["There", "are", "no", "significant", "differences", "between", "C0034414#ent", "<e1>", ",", "verapamil", "and", "C0002598#ent", "<e2>", "regarding", "its", "prophylactic", "efficacy"], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002598", "name": "C0002598#ent", "pos": [11, 12]}}
{"token": ["C0034414#ent", "<e1>", ",", "propafenone", ",", "flecainide", ",", "C0002598#ent", "<e2>", "and", "verapamil", "increase", "blood", "digoxin", "levels", ",", "sometimes", "to", "twice", "their", "baseline", "values", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002598", "name": "C0002598#ent", "pos": [7, 8]}}
{"token": ["PKCtheta", "triggers", "C0752312#ent", "<e1>", "phosphorylation", "of", "C1705887#ent", "<e2>", ",", "and", "increases", "transcriptional", "activity", "C1705887#ent", "<e2>", ",", "cooperatively", "with", "p300", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705887", "name": "C1705887#ent", "pos": [6, 7]}}
{"token": ["The", "steroid", "receptor", "coactivator-3", "SRC-3", ")", ",", "also", "known", "as", "p/CIP", ",", "RAC3", ",", "AIB1", ",", "ACTR", "and", "C1705553#ent", "<e1>", ",", "is", "a", "cancer-amplified", "coactivator", "the", "SRC", "C1517488#ent", "<e2>", "also", "contains", "SRC-1", "and", "TIF2/GRIP1", "."], "h": {"id": "C1705553", "name": "C1705553#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [27, 28]}}
{"token": ["Intraalveolar", "fibrinolysis", ",", "is", "regulated", "by", "the", "concerted", "actions", "of", "plasmin", ",", "plasminogen", "activators", "C0030125#ent", "<e1>", ")", ",", "and", "their", "specific", "inhibitors", "(", "C1414989#ent", "<e2>", ")", "."], "h": {"id": "C0030125", "name": "C0030125#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414989", "name": "C1414989#ent", "pos": [23, 24]}}
{"token": ["The", "variable-stressor", "paradigm", "produces", "a", "syndrome", "consistent", "with", "chronic", "stress", "including", "baseline", "C0037036#ent", "<e1>", "of", "corticosterone", ",", "ACTH", "and", "C1418938#ent", "<e2>", ",", "and", "adrenal", "hypertrophy"], "h": {"id": "C0037036", "name": "C0037036#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [19, 20]}}
{"token": ["C0040156#ent", "<e1>", "commenced", "before", "that", "of", "C1840402#ent", "<e2>", "in", "twenty-three", "patients", "(", "53", "%", ")", "whereas", "in", "the", "remaining", "twenty", "patients", "it", "was", "impossible", "to", "determine", "which", "disease", "began", "first", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [6, 7]}}
{"token": ["Using", "two", "different", "radioimmunoassay", "systems", "a", "total", "of", "44", "determinations", ",", "mean", "parathyroid", "hormone", "levels", "were", "lower", "in", "C0040156#ent", "<e1>", "patients", "than", "in", "subjects", "with", "proved", "C1840402#ent", "<e2>", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [26, 27]}}
{"token": ["These", "syndromes", "have", "been", "found", "to", "be", "genetically", "heterogeneous", "with", "a", "single", "locus", "for", "USH2", "at", "1q41", "(", "C1421381#ent", "<e1>", ")", ",", "six", "loci", "for", "C1568247#ent", "<e2>", ",", "and", "one", "for", "USH3", "."], "h": {"id": "C1421381", "name": "C1421381#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1568247", "name": "C1568247#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "immunostaining", "for", "C1421381#ent", "<e1>", "can", "serve", "as", "a", "reliable", "diagnostic", "tool", "C1568247#ent", "<e2>"], "h": {"id": "C1421381", "name": "C1421381#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1568247", "name": "C1568247#ent", "pos": [13, 14]}}
{"token": ["The", "commonest", "aetiologies", "identified", "were", "C0393484#ent", "<e1>", "n", "=", "7", ";", "19", "%", ")", "and", "C0007820#ent", "<e2>", "n", "=", "5", ";", "14", "%", ")", "."], "h": {"id": "C0393484", "name": "C0393484#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [15, 16]}}
{"token": ["Internalization", "of", "EGF", "and", "insulin", "was", "not", "affected", "by", "full-length", "C1419253#ent", "<e1>", "which", "is", "an", "effector", "protein", "C0244404#ent", "<e2>", ",", "but", "was", "inhibited", "by", "its", "C-terminal", "region", "binds", "directly", "to", "C0244404#ent", "<e2>", "and", "POB1", "."], "h": {"id": "C1419253", "name": "C1419253#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0244404", "name": "C0244404#ent", "pos": [17, 18]}}
{"token": ["The", "specificity", "of", "the", "enzyme", "activity", "immunoblotting", "and", "reverse", "transcriptase-polymerase", "chain", "reaction", "analyses", "that", "these", "cells", "expressed", "C2827465#ent", "<e1>", "and", "not", "PAD1", ",", "C2986918#ent", "<e2>", "or", "PAD4", "."], "h": {"id": "C2827465", "name": "C2827465#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2986918", "name": "C2986918#ent", "pos": [23, 24]}}
{"token": ["The", "C3541394#ent", "<e1>", "are", "inactivated", "by", "C0048723#ent", "<e2>", "suggests", "the", "presence", "of", "an", "essential", "serine", "in", "the", "active", "sites", "the", "C3541394#ent", "<e1>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0048723", "name": "C0048723#ent", "pos": [6, 7]}}
{"token": ["The", "C0085860#ent", "<e1>", "APSI", ")", "is", "an", "auto-somal", "recessive", "disorder", "is", "characterized", "by", "C0006845#ent", "<e2>", "multiple", "autoimmune", "endocrinopathies", "and", "ectodermal", "dystrophies"], "h": {"id": "C0085860", "name": "C0085860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006845", "name": "C0006845#ent", "pos": [13, 14]}}
{"token": ["C0085860#ent", "<e1>", "a", "rare", "disorder", "characterized", "by", "C0006845#ent", "<e2>", "MC", ")", ",", "hypoparathyroidism", "(", "HP", ")", "and", "adrenal", "insufficiency", "requiring", "regular", "follow", "up", "as", "the", "components", "of", "the", "syndrome", "appear", "at", "different", "age", "groups"], "h": {"id": "C0085860", "name": "C0085860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006845", "name": "C0006845#ent", "pos": [7, 8]}}
{"token": ["BTB", ",", "which", "usually", "subsides", "within", "a", "few", "months", ",", "is", "related", "to", "the", "dose", ",", "potency", ",", "and", "ratio", "of", "the", "estrogen", "and", "C3536710#ent", "<e1>", "in", "the", "C1412791#ent", "<e2>", "formulation", "."], "h": {"id": "C3536710", "name": "C3536710#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [28, 29]}}
{"token": ["C0010583#ent", "<e1>", "(", "CYC", ")", "pulse", "therapy", "effective", "in", "suppressing", "C0002390#ent", "<e2>"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002390", "name": "C0002390#ent", "pos": [10, 11]}}
{"token": ["Although", "there", "is", "still", "no", "ideal", "specific", "pharmacologic", "therapy", "SSc", ",", "C0010583#ent", "<e1>", "has", "resulted", "in", "clinical", "improvement", "patients", "with", "SSc-related", "C0002390#ent", "<e2>"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002390", "name": "C0002390#ent", "pos": [21, 22]}}
{"token": ["Eight", "patients", "over", "age", "60", "years", "had", "sudden", "onset", "C0000737#ent", "<e1>", "rectal", "bleeding", "the", "absence", "of", "prior", "C0010346#ent", "<e2>"], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "the", "granules", "contain", "C0072522#ent", "<e1>", ",", "phospholipid", ",", "lipoprotein", "and", "C0391845#ent", "<e2>"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [14, 15]}}
{"token": ["Lectin", "labeling", "indicated", "that", "most", "of", "the", "polypeptides", "from", "the", "membrane", "and", "from", "the", "sap", "were", "C0072522#ent", "<e1>", "probably", "of", "the", "high-mannose", "type", "characteristic", "of", "C0391845#ent", "<e2>", "have", "undergone", "several", "stages", "of", "posttranslational", "modification"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [25, 26]}}
{"token": ["There", "was", "an", "increase", "in", "dolichol", "levels", ",", "carbohydrate", "residues", "C0072522#ent", "<e1>", ",", "glycolipids", ",", "total/individual", "GAG", "fractions", ",", "and", "C0391845#ent", "<e2>", "ME", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [20, 21]}}
{"token": ["The", "insulin-like", "growth", "factor-II/mannose", "6-phosphate", "receptor", "IGF-II/MPR", ")", "is", "a", "C0072522#ent", "<e1>", "mediates", "both", "the", "intracellular", "sorting", "of", "C0391845#ent", "<e2>", "mannose", "6-phosphate", "Man-6-P", ")", "residues", "to", "the", "lysosome", "and", "the", "bioavailability", "of", "IGF-II", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [18, 19]}}
{"token": ["We", "describe", "a", "47-year-old", "patient", "who", "developed", "C0008350#ent", "<e1>", "in", "adolescence", ",", "followed", "by", "recurrent", "C0268312#ent", "<e2>", "pregnancy", ",", "and", "finally", "biliary", "cirrhosis", "adulthood", "."], "h": {"id": "C0008350", "name": "C0008350#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268312", "name": "C0268312#ent", "pos": [15, 16]}}
{"token": ["Mildly", "affected", "individuals", "from", "C1567673#ent", "<e1>", "XP-G", ")", "possess", "single", "amino", "acid", "substitutions", "in", "the", "C1333359#ent", "<e2>", "adversely", "affects", "its", "3", "'", "endonuclease", "function", "nucleotide", "excision", "repair"], "h": {"id": "C1567673", "name": "C1567673#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333359", "name": "C1333359#ent", "pos": [15, 16]}}
{"token": ["The", "data", "indicate", "that", "C0025945#ent", "<e1>", "occur", "in", "the", "individual", "with", "C0010674#ent", "<e2>"], "h": {"id": "C0025945", "name": "C0025945#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [11, 12]}}
{"token": ["C0063555#ent", "<e1>", "acted", "much", "more", "rapidly", "than", "C0021974#ent", "<e2>", "(", "15", "seconds", "versus", "300", "seconds", ")", "and", "did", "not", "cause", "the", "onset", "of", "O(2", ")", "evolution", "often", "observed", "with", "C0021974#ent", "<e2>", "."], "h": {"id": "C0063555", "name": "C0063555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021974", "name": "C0021974#ent", "pos": [7, 8]}}
{"token": ["The", "C0031727#ent", "<e1>", "consisting", "of", "C1335632#ent", "<e2>", "and", "ROCK2", ",", "has", "been", "implicated", "in", "cardiac", "hypertrophy", "ventricular", "remodeling"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1335632", "name": "C1335632#ent", "pos": [5, 6]}}
{"token": ["They", "include", "C0031727#ent", "<e1>", "as", "phosphatidyl-inositol-5-kinase", "and", "protein", "serine/threonine", "kinases", "as", "PKN", "and", "C1335632#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1335632", "name": "C1335632#ent", "pos": [13, 14]}}
{"token": ["The", "acute", "effect", "three", "C0003211#ent", "<e1>", "ibuprofen", ",", "acetylsalicylic", "acid", "ASA", ")", "and", "C0015837#ent", "<e2>", ",", "on", "faecal", "blood", "loss", "investigated", "in", "15", "subjects", "by", "means", "of", "51Cr-labelled", "erythrocytes", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0015837", "name": "C0015837#ent", "pos": [13, 14]}}
{"token": ["Several", "C0003211#ent", "<e1>", "are", "cyclooxygenase", "inhibitors", "e.g.", ",", "salicylates", ",", "C0015837#ent", "<e2>", ",", "ibuprofen", ")", "have", "been", "shown", "to", "suppress", "proteoglycan", "synthesis", "by", "normal", "joint", "cartilage", "in", "vitro"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [1, 2]}, "relation": "structural_class_of", "t": {"id": "C0015837", "name": "C0015837#ent", "pos": [10, 11]}}
{"token": ["This", "may", "be", "reflected", ",", "for", "example", ",", "in", "the", "pathogenicity", "and", "severity", "of", "C0027765#ent", "<e1>", "such", "as", "C0348165#ent", "<e2>"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0348165", "name": "C0348165#ent", "pos": [18, 19]}}
{"token": ["C1824584#ent", "<e1>", "could", "synergistically", "stimulate", "TTF-1-activated", "SP-B", "and", "C1442758#ent", "<e2>", "promoter", "activities", "H441", "cells", "(", "a", "lung", "adenocarcinoma", "cell", "."], "h": {"id": "C1824584", "name": "C1824584#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1442758", "name": "C1442758#ent", "pos": [8, 9]}}
{"token": ["When", "a", "recombinant", "P2Y1", "purinoceptor", "derived", "from", "chick", "brain", ")", "is", "expressed", "in", "Xenopus", "oocytes", "C1705556#ent", "<e1>", "and", "2-methylthioATP", "(", "2-MeSATP", ")", "evoke", "C1332764#ent", "<e2>", "ICl", ",", "Ca", ")", "in", "a", "concentration-dependent", "manner", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332764", "name": "C1332764#ent", "pos": [23, 24]}}
{"token": ["Acyclovir", "treatment", "was", "used", "in", "a", "randomized", ",", "double-blind", ",", "placebo-controlled", "clinical", "trial", "parallel", "groups", "test", "the", "hypothesis", "that", "C0149678#ent", "<e1>", "involved", "in", "the", "pathogenesis", "of", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [28, 29]}}
{"token": ["This", "may", "be", "suggestive", "of", "a", "lack", "of", "primary", "infections", "C0026269#ent", "<e1>", "patients", ",", "and", "thus", "strengthens", "the", "idea", "that", "C0026269#ent", "<e1>", "patients", "are", "infected", "with", "C0149678#ent", "<e1>", "before", "development", "of", "C0026269#ent", "<e1>", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [10, 11]}}
{"token": ["Nimodipine", "reduced", "the", "amplitude", "of", "C3539699#ent", "<e1>", "+", "current", "inhibition", "by", "C0525773#ent", "<e2>", ",", "suggesting", "that", "mu-opioid", "receptors", "to", "L-type", "Ca2", "+", "channels", "in", "GH3MOR", "cells", "."], "h": {"id": "C3539699", "name": "C3539699#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0525773", "name": "C0525773#ent", "pos": [11, 12]}}
{"token": ["C3539699#ent", "<e1>", "+", "current", "inhibitions", "by", "both", "C0525773#ent", "<e2>", "and", "DPDPE", "were", "completely", "reversed", "by", "depolarizing", "(", "to", ">", "50", "mV", ")", "prepulses", "in", "GH3MORDOR", "cells", "."], "h": {"id": "C3539699", "name": "C3539699#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0525773", "name": "C0525773#ent", "pos": [7, 8]}}
{"token": ["Various", "inborn", "defects", "in", "homocysteine", "metabolism", "among", "which", "C0751202#ent", "<e1>", "most", "common", ",", "lead", "to", "the", "clinical", "condition", "C0019880#ent", "<e2>", "."], "h": {"id": "C0751202", "name": "C0751202#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [18, 19]}}
{"token": ["The", "activity", "of", "the", "C0599930#ent", "<e1>", "cyto-chrome", "P-450", "depressed", "in", "the", "liver", "of", "guinea-pigs", "with", "C0003969#ent", "<e2>"], "h": {"id": "C0599930", "name": "C0599930#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003969", "name": "C0003969#ent", "pos": [15, 16]}}
{"token": ["The", "potency", "order", "of", "C4084713#ent", "<e1>", "constructs", "for", "activation", "of", "CFTR", "(", "C4084713#ent", "<e1>", "membrane-bound", "cGK", "I", "chimer", ">", ">"], "h": {"id": "C4084713", "name": "C4084713#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4084713", "name": "C4084713#ent", "pos": [4, 5]}}
{"token": ["The", "skTnT", "protein", "interacted", "with", "C4084713#ent", "<e1>", "Ibeta", "but", "not", "with", "C4084713#ent", "<e1>", "cAMP-dependent", "protein", "kinase"], "h": {"id": "C4084713", "name": "C4084713#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4084713", "name": "C4084713#ent", "pos": [5, 6]}}
{"token": ["Upon", "C3539637#ent", "<e1>", "treatment", ",", "acetylated", "Ku70", "releases", "C0812198#ent", "<e2>", ",", "allowing", "it", "to", "translocate", "to", "mitochondria", "and", "trigger", "cytochrome", "c", ",", "leading", "to", "caspase-dependent", "death"], "h": {"id": "C3539637", "name": "C3539637#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [8, 9]}}
{"token": ["Restriction", "of", "C0012177#ent", "<e1>", "slow", "the", "progression", "of", "renal", "failure", "diverse", "C0012634#ent", "<e2>", "but", "the", "extent", "to", "which", "such", "a", "diet", "is", "beneficial", "in", "patients", "with", "diabetic", "nephropathy", "uncertain", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["The", "pattern", "of", "arterial", "occlusion", "C0017661#ent", "<e1>", "analyzed", "by", "simultaneous", "bilateral", "femoral", "arteriography", "in", "210", "C0030196#ent", "<e2>", "of", "105", "patients", "with", "C0017661#ent", "<e1>"], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [5, 6]}}
{"token": ["We", "surveyed", "the", "recent", "condition", "of", "lower", "C0030196#ent", "<e1>", "with", "failed", "vascular", "reconstruction", "patients", "with", "C0017661#ent", "<e2>"], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [15, 16]}}
{"token": ["To", "study", "the", "mechanism", "of", "haemolysis", "in", "C1333652#ent", "<e1>", "deficient", "erythrocytes", ",", "studies", "were", "undertaken", "in", "C2939465#ent", "<e2>", "in", "normal", "erythrocytes", "artificially", "loaded", "with", "calcium", "."], "h": {"id": "C1333652", "name": "C1333652#ent", "pos": [7, 8]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C2939465", "name": "C2939465#ent", "pos": [16, 17]}}
{"token": ["We", "have", "used", "the", "polymerase", "chain", "reaction", "nucleotide", "sequence", "analysis", "characterize", "a", "new", "G6PD", "variant", ",", "which", "we", "designate", "as", "C1333652#ent", "<e1>", "in", "a", "C2939465#ent", "<e2>", "boy", "affected", "by", "CNSHA", "."], "h": {"id": "C1333652", "name": "C1333652#ent", "pos": [20, 21]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C2939465", "name": "C2939465#ent", "pos": [24, 25]}}
{"token": ["The", "mutation", "at", "Ser(680", ")", "led", "to", "enhanced", "C1447339#ent", "<e1>", "activity", "of", "C1336848#ent", "<e2>", "toward", "poly-ubiquitin", "chains", "and", "a", "cellular", "substrate", "epidermal", "growth", "factor", "receptor", "in", "vitro", "in", "vivo"], "h": {"id": "C1447339", "name": "C1447339#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1336848", "name": "C1336848#ent", "pos": [12, 13]}}
{"token": ["Given", "the", "potential", "physiological", "consequences", "of", "cardiac", "MyHC", "isoform", "shifts", ",", "we", "determined", "C1417537#ent", "<e1>", "gene", "expression", "in", "human", "C0018801#ent", "<e2>", "cardiac", "contractility", "impaired", "significantly", "."], "h": {"id": "C1417537", "name": "C1417537#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["Dexamethasone-beta-D-glucuronide", ",", "a", "colon-specific", "prodrug", "of", "C0011777#ent", "<e1>", ",", "may", "be", "useful", "in", "the", "treatment", "of", "C0009324#ent", "<e2>", "Crohn's", "colitis"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "patients", "receiving", "CCBs", ",", "particularly", "C0016295#ent", "<e1>", "and", "cinnarizine", ",", "should", "be", "monitored", "for", "C0221271#ent", "<e2>", "."], "h": {"id": "C0016295", "name": "C0016295#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0221271", "name": "C0221271#ent", "pos": [17, 18]}}
{"token": ["EMSA", "experiments", "VPA-mediated", "augmentation", "of", "CAR/retinoid", "X", "receptor", "alpha", "heterodimer", "binding", "to", "direct", "repeat", "3", "(", "DR3", ")", "and", "C1336643#ent", "<e1>", "responsive", "elements", "of", "CYP3A4", "and", "MDR1", "C0017337#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1336643", "name": "C1336643#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [27, 28]}}
{"token": ["Combination", "of", "C0046319#ent", "<e1>", "treatment", "with", "localized", "44", "degrees", "C", "hyperthermia", ",", "respiratory", "hyperoxia", "C1421531#ent", "<e2>", "a", "tumor", "growth", "delay", "51", "%", "of", "tumors", "cured", "."], "h": {"id": "C0046319", "name": "C0046319#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [14, 15]}}
{"token": ["Obesity", "induces", "an", "increase", "in", "C1453952#ent", "<e1>", "perhaps", "in", "women", "because", "of", "lower", "C2936882#ent", "<e2>", "levels", ",", "which", "is", "associated", "with", "HDL", "concentrations", ",", "and", "altered", "HDL", "composition", "."], "h": {"id": "C1453952", "name": "C1453952#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [13, 14]}}
{"token": ["It", "is", ",", "however", ",", "extremely", "C1334043#ent", "<e1>", "to", "a", "third", "'", "non-classical", "'", "gene", ",", "C4085202#ent", "<e2>", ",", "and", "to", "the", "chimpanzee", "gene", "Ch28", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4085202", "name": "C4085202#ent", "pos": [16, 17]}}
{"token": ["The", "adenosine", "A1", "receptor-selective", "antagonist", "dipropylxanthine", "(", "DPCPX", ")", "inhibited", "the", "contractions", "produced", "by", "all", "the", "C2936550#ent", "<e1>", "tested", ",", "with", "C1705341#ent", "<e2>", "values", "between", "9.2", "and", "9.5", "."], "h": {"id": "C2936550", "name": "C2936550#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [21, 22]}}
{"token": ["C1420783#ent", "<e1>", "LAP", ")", "2alpha", "is", "a", "LEM", "(", "C3538883#ent", "<e2>", "family", "protein", "associated", "with", "nucleoplasmic", "A-type", "lamins", "chromatin", "."], "h": {"id": "C1420783", "name": "C1420783#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3538883", "name": "C3538883#ent", "pos": [9, 10]}}
{"token": ["Here", ",", "we", "examined", "whether", "the", "insulin-sensitizing", "effect", "of", "C0872972#ent", "<e1>", "affects", "the", "C1332762#ent", "<e2>", "induction", "."], "h": {"id": "C0872972", "name": "C0872972#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332762", "name": "C1332762#ent", "pos": [13, 14]}}
{"token": ["One", "case", "of", "C0012546#ent", "<e1>", "one", "of", "C0012553#ent", "<e2>", "observed", "."], "h": {"id": "C0012546", "name": "C0012546#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012553", "name": "C0012553#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", "we", "observed", "that", "a", "group", "of", "C0085169#ent", "<e1>", "clearly", "mutagenic", "in", "the", "C0022959#ent", "<e2>", "transgenic", "mouse", "oral", "cavity"], "h": {"id": "C0085169", "name": "C0085169#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022959", "name": "C0022959#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "report", "the", "characterization", "of", "a", "new", "human", "TAF", ",", "C1704906#ent", "<e1>", ",", "which", "is", "the", "human", "C1334043#ent", "<e2>", "of", "Drosophila", "TAFII80", "and", "yeast", "TAFII90", "."], "h": {"id": "C1704906", "name": "C1704906#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["Shigella", "dysenteriae", "type", "1", "strains", "not", "produce", "aerobactin", "but", "do", "contain", "sequences", "downstream", "of", "C1332682#ent", "<e1>", "that", "are", "C1334043#ent", "<e2>", "to", "SHI-2", "."], "h": {"id": "C1332682", "name": "C1332682#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["The", "beginning", "of", "a", "fourth", "open", "reading", "frame", "C1332682#ent", "<e1>", ")", "which", "was", "C1334043#ent", "<e2>", "to", "the", "C.", "saccharolyticus", "manA", "and", "celA", "genes", "located", "at", "the", "3", "'", "end", "of", "the", "12-kb", "NZP", "lambda", "2", "genomic", "fragment"], "h": {"id": "C1332682", "name": "C1332682#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}}
{"token": ["Loratadine", "is", "a", "more", "potent", "inhibitor", "of", "C0015263#ent", "<e1>", "guinea", "pigs", "than", "is", "C0085173#ent", "<e2>", "."], "h": {"id": "C0015263", "name": "C0015263#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [13, 14]}}
{"token": ["Nevertheless", ",", "the", "content", "of", "C0011501#ent", "<e1>", "is", "even", "higher", "in", "cells", "treated", "with", "C1333714#ent", "<e2>", "and", "TPA", "than", "in", "cells", "treated", "with", "C1333714#ent", "<e2>", "alone", "."], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [14, 15]}}
{"token": ["Gastrin", "secretion", "was", "investigated", "under", "both", "basal", "conditions", "and", "stimulation", "by", "C0011501#ent", "<e1>", ",", "food", "or", "C1333714#ent", "<e2>", "."], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [16, 17]}}
{"token": ["The", "purification", "scheme", "yielded", "essentially", "homogeneous", "preparations", "of", "the", "C0038302#ent", "<e1>", "and", "also", "purified", "another", "C1970415#ent", "<e2>", "pyrimidine", "deoxyribonucleoside", "2'-hydroxylase", "EC", "1.14.11.3", ")", "."], "h": {"id": "C0038302", "name": "C0038302#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1970415", "name": "C1970415#ent", "pos": [15, 16]}}
{"token": ["Although", "most", "cases", "with", "chronic", "liver", "disease", "caused", "by", "hepatitis", "B", "virus", "HBV", ")", "or", "C4288963#ent", "<e1>", "there", "are", "still", "cases", "of", "C0019196#ent", "<e2>", ",", "non-C", "chronic", "liver", "disease"], "h": {"id": "C4288963", "name": "C4288963#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019196", "name": "C0019196#ent", "pos": [22, 23]}}
{"token": ["Signal", "regulatory", "protein", "C1705300#ent", "<e1>", ")", "alpha1", "is", "a", "member", "of", "the", "C1705300#ent", "<e1>", "family", "that", "undergoes", "tyrosine", "phosphorylation", "binds", "C0214604#ent", "<e1>", "response", "to", "various", "mitogens", "."], "h": {"id": "C1705300", "name": "C1705300#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0214604", "name": "C0214604#ent", "pos": [20, 21]}}
{"token": ["To", "study", "the", "effects", "of", "high", "glucose", "C1515406#ent", "<e1>", "TGF-beta", "1", ")", "on", "the", "expression", "and", "function", "of", "C1335837#ent", "<e2>", "GLUT1", ")", "in", "mouse", "mesangial", "cells"], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335837", "name": "C1335837#ent", "pos": [18, 19]}}
{"token": ["We", "now", "report", "statistically", "significant", "at", "P", "greater", "than", "0.999", ")", "enhancement", "of", "transformation", "response", "by", "C0032143#ent", "<e1>", "in", "cells", "exposed", "to", "microwaves", "(", "C4283882#ent", "<e2>", "=", "4.4", "W/kg", ")", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4283882", "name": "C4283882#ent", "pos": [24, 25]}}
{"token": ["TGF-beta", "is", "activated", "by", "plasmin", "which", "is", "positively", "regulated", "by", "C0032143#ent", "<e1>", "PA", ")", "and", "PA", "receptor", "C4283882#ent", "<e2>", ")", ",", "and", "negatively", "regulated", "by", "plasminogen", "activator", "inhibitor", "PAI", ")", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4283882", "name": "C4283882#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "used", "suppression", "subtractive", "hybridization", "identify", "C1412477#ent", "<e1>", "apoC-II", ")", "as", "an", "FXR", "target", "C0079429#ent", "<e2>", "."], "h": {"id": "C1412477", "name": "C1412477#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["MXI1", "and", "C1332028#ent", "<e1>", "appear", "to", "be", "about", "600", "kb", "apart", ",", "whereas", "C1439273#ent", "<e2>", "is", "separated", "from", "C1332028#ent", "<e1>", "by", "a", "distance", "larger", "than", "previously", "reported", "."], "h": {"id": "C1332028", "name": "C1332028#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1439273", "name": "C1439273#ent", "pos": [13, 14]}}
{"token": ["C0021251#ent", "<e1>", "appears", "to", "offer", "an", "effective", "and", "safe", "alternative", "to", "C0027409#ent", "<e2>", "acute", "pain", "to", "fractures", "."], "h": {"id": "C0021251", "name": "C0021251#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027409", "name": "C0027409#ent", "pos": [11, 12]}}
{"token": ["It", "had", "been", "shown", "that", "milrinone", ",", "a", "C2987233#ent", "<e1>", "inhibitor", ",", "was", "as", "potent", "as", "C0529793#ent", "<e2>", ",", "a", "PDE5", "inhibitor", ",", "in", "relaxing", "human", "corpus", "cavernosum"], "h": {"id": "C2987233", "name": "C2987233#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0529793", "name": "C0529793#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "like", "C0008402#ent", "<e1>", ",", "colestipol", "is", "of", "benefit", "in", "patients", "with", "C0020443#ent", "<e2>", "associated", "hypertriglyceridaemia", "(", "type", "IIa", "hyperlipoproteinaemia", "."], "h": {"id": "C0008402", "name": "C0008402#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [13, 14]}}
{"token": ["Some", "amino", "acid", "substitutions", "previously", "reported", "to", "lead", "to", "C0751434#ent", "<e1>", "were", "detected", "in", "the", "present", "study", "in", "compound", "heterozygotes", "severe", "C0751434#ent", "<e1>", "."], "h": {"id": "C0751434", "name": "C0751434#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0751434", "name": "C0751434#ent", "pos": [9, 10]}}
{"token": ["C3540524#ent", "<e1>", "mutant", "extracts", "exhibited", "normal", "C1332461#ent", "<e2>", "but", "were", "defective", "in", "responding", "to", "GAL4-VP16", ",", "GCN4", ",", "or", "the", "dA", ":", "dT", "activator", "."], "h": {"id": "C3540524", "name": "C3540524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332461", "name": "C1332461#ent", "pos": [6, 7]}}
{"token": ["C0022180#ent", "<e1>", "1.0", "MAC", "reduced", "C0066621#ent", "<e2>", "infusion", "requirements", "by", "32", "%", "(", "p", "<", "0.01", ")", "."], "h": {"id": "C0022180", "name": "C0022180#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0066621", "name": "C0066621#ent", "pos": [5, 6]}}
{"token": ["Previous", "experimental", "studies", "rats", "with", "early", "C0022661#ent", "<e1>", "adriamycin", "nephropathy", "AN", ")", "have", "shown", "that", "this", "C0852036#ent", "<e2>", "associated", "with", "lowered", "synthesis", "of", "glomerular", "PGE2", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0852036", "name": "C0852036#ent", "pos": [16, 17]}}
{"token": ["Mast", "cell", "numbers", "are", "significantly", "increased", "in", "C0005686#ent", "<e1>", "malignancy", "and", "C0282488#ent", "<e2>", "but", "their", "precise", "role", "has", "been", "difficult", "to", "determine", "."], "h": {"id": "C0005686", "name": "C0005686#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0282488", "name": "C0282488#ent", "pos": [11, 12]}}
{"token": ["However", ",", "nitric", "oxide", "from", "other", "sources", "may", "have", "a", "role", "in", "C0005686#ent", "<e1>", "such", "as", "C0282488#ent", "<e2>"], "h": {"id": "C0005686", "name": "C0005686#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0282488", "name": "C0282488#ent", "pos": [16, 17]}}
{"token": ["C0061851#ent", "<e1>", "and", "perphenazine", "had", "similar", "effects", "on", "C0520909#ent", "<e2>", "44", "%", "vs", "41", "%", ";", "ondansetron", "vs", "perphenazine", "P", "=", "0.77", ")", "."], "h": {"id": "C0061851", "name": "C0061851#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0520909", "name": "C0520909#ent", "pos": [8, 9]}}
{"token": ["C1334510#ent", "<e1>", "had", "little", "effect", "on", "C0525189#ent", "<e2>", "actions", ",", "while", "DH-beta-E", "completely", "reversed", "them", "."], "h": {"id": "C1334510", "name": "C1334510#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0525189", "name": "C0525189#ent", "pos": [6, 7]}}
{"token": ["Patients", "affected", "by", "malignant", ",", "chronic", "or", "C0001314#ent", "<e1>", "could", "directly", "increase", "cytokine", "production", "C1710304#ent", "<e2>", ",", "IL-1", ",", "etc", ".", ")"], "h": {"id": "C0001314", "name": "C0001314#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [14, 15]}}
{"token": ["The", "total", "amount", "of", "TRI", "C0025517#ent", "<e1>", "was", "considered", "in", "the", "most", "recent", "EPA", "Health", "Document", "for", "C0040905#ent", "<e2>", "to", "be", "the", "effective", "dose", "EFD", ")", "producing", "tumors", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040905", "name": "C0040905#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "the", "depolymerization", "of", "actin", "filaments", "C0103049#ent", "<e1>", "did", "not", "affect", "the", "capacity", "of", "C1705756#ent", "<e2>", "to", "translocate", "."], "h": {"id": "C0103049", "name": "C0103049#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705756", "name": "C1705756#ent", "pos": [15, 16]}}
{"token": ["The", "main", "clinical", "picture", "31", "toxic", ",", "22", "C0014060#ent", "<e1>", "or", "meningeal", "irritating", ",", "15", "C0152517#ent", "<e2>", ",", "9", "pneumonic", ",", "8", "perforated", "and", "3", "haemorrhagic", "enteric", "fever", "cases", "were", "discussed", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0152517", "name": "C0152517#ent", "pos": [15, 16]}}
{"token": ["Clinical", "diagnoses", "associated", "with", "enteroviral", "isolations", "included", "aseptic", "meningitis", "C0014060#ent", "<e1>", ",", "upper", "respiratory", "tract", "disease", "non-specific", "febrile", "illness", ",", "C0152517#ent", "<e2>", ",", "pneumonia", "and", "lower", "respiratory", "tract", "disease", "exanthem", ",", "and", "enanthem", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0152517", "name": "C0152517#ent", "pos": [20, 21]}}
{"token": ["The", "biosynthetic", "genes", "code", "C3540772#ent", "<e1>", "that", "possess", "C2347702#ent", "<e2>", "cyclase", ",", "epimerase", ",", "expandase", ",", "hydroxylase", ",", "lysine", "aminotransferase", "and", "acetyltransferase", "activities", "are", "organized", "in", "chromosomal", "gene", "clusters", "and", "coordinately", "expressed", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2347702", "name": "C2347702#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "C0072798#ent", "<e1>", "inactivates", "both", "active", "transport", "proline", "and", "C0031727#ent", "<e2>", "system-dependent", "group", "translocation", "of", "alpha-methylglucoside", "."], "h": {"id": "C0072798", "name": "C0072798#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}}
{"token": ["The", "ability", "to", "induce", "tolerance", "to", "C0041931#ent", "<e1>", "by", "the", "administration", "of", "native", "C0041931#ent", "<e1>", ",", "and", "C0041931#ent", "<e1>", "modified", "by", "the", "covalent", "attachment", "C0032483#ent", "<e1>", "PEG", ")", "was", "examined", "."], "h": {"id": "C0041931", "name": "C0041931#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [24, 25]}}
{"token": ["Uricase", "from", "C.", "utilis", "and", "C0041931#ent", "<e1>", "to", "which", "C0032483#ent", "<e2>", "been", "attached", "were", "injected", "into", "leghorn", "cockerels", "in", "an", "attempt", "to", "lower", "plasma", "urate", "levels", "."], "h": {"id": "C0041931", "name": "C0041931#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [9, 10]}}
{"token": ["ELISA", "was", "used", "to", "measure", "tissue", "plasminogen", "activator", "antigen", "blood", "plasma", "urine", "of", "42", "patients", "with", "C0024143#ent", "<e1>", "16", "with", "isolated", "C0042075#ent", "<e2>", "13", "with", "nephrotic", "syndrome", "13", "with", "rapidly", "progressive", "LN", ")", "."], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [21, 22]}}
{"token": ["Venous", "occlusion", "test", "found", "out", "the", "reserve", "of", "vascular", "and", "renal", "endothelium", "excretion", "of", "Willebrand", "factor", "patients", "with", "inactive", "C0024143#ent", "<e1>", "those", "with", "active", "lupus", "nephritis", "C0042075#ent", "<e2>"], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [26, 27]}}
{"token": ["This", "study", "provides", "a", "basis", "for", "development", "of", "gene", "therapy", "the", "C0213574#ent", "<e1>", "deficient", "form", "of", "C1863999#ent", "<e2>", "."], "h": {"id": "C0213574", "name": "C0213574#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1863999", "name": "C1863999#ent", "pos": [16, 17]}}
{"token": ["Cytosolic", "components", "of", "human", "neutrophils", ",", "p47phox", "and", "C0213574#ent", "<e1>", ",", "deficiencies", "of", "which", "lead", "to", "chronic", "granulomatous", "disease", "C1863999#ent", "<e2>", ")", ",", "potentiate", "respiratory", "burst", "oxidase", "translocating", "from", "cytosol", "to", "membrane", "upon", "cell", "stimulation"], "h": {"id": "C0213574", "name": "C0213574#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1863999", "name": "C1863999#ent", "pos": [19, 20]}}
{"token": ["A", "selective", "decrease", "in", "intracellular", "staining", "C0213574#ent", "<e1>", "suggested", "the", "diagnosis", "of", "autosomal", "recessive", "C1863999#ent", "<e2>", "due", "to", "NCF-2", "gene", "mutations", "and", "a", "novel", "homozygous", "and", "hypomorphic", "NCF-2", "gene", "was", "found", "."], "h": {"id": "C0213574", "name": "C0213574#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1863999", "name": "C1863999#ent", "pos": [14, 15]}}
{"token": ["Drug", "combination", "studies", "synergy", "between", "pyronaridine", "and", "primaquine", ",", "additive", "effects", "4-aminoquinolines", ",", "and", "weak", "antagonism", "with", "C0052432#ent", "<e1>", ",", "antifolates", ",", "or", "C0001975#ent", "<e2>"], "h": {"id": "C0052432", "name": "C0052432#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [23, 24]}}
{"token": ["The", "new", "derivatives", "were", "prepared", "in", "good", "yield", "by", "treatment", "of", "C0052432#ent", "<e1>", "with", "an", "appropriate", "C0001975#ent", "<e2>", "under", "boron", "trifluoride", "etherate", "catalysis", "at", "room", "temperature"], "h": {"id": "C0052432", "name": "C0052432#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "C0033628#ent", "<e1>", "transported", "by", "MRP1", "and", "C2828741#ent", "<e2>", "."], "h": {"id": "C0033628", "name": "C0033628#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2828741", "name": "C2828741#ent", "pos": [9, 10]}}
{"token": ["Several", "of", "these", "genes", "are", "involved", "in", "the", "development", "of", "the", "olfactory", "nervous", "system", "with", "mutations", "typically", "resulting", "in", "anosmia/hyposmia", "and", "C0271623#ent", "<e1>", "otherwise", "known", "as", "C1563719#ent", "<e2>"], "h": {"id": "C0271623", "name": "C0271623#ent", "pos": [21, 22]}, "relation": "manifestation_of", "t": {"id": "C1563719", "name": "C1563719#ent", "pos": [26, 27]}}
{"token": ["This", "new", "approach", "might", "be", "useful", "to", "differentiate", "C0016399#ent", "<e1>", "emerging", "from", "NREM", "sleep", "from", "parasomnias", "(", "C0752294#ent", "<e2>", "when", "both", "ictal", "and", "interictal", "EEGs", "are", "uninformative", "."], "h": {"id": "C0016399", "name": "C0016399#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752294", "name": "C0752294#ent", "pos": [17, 18]}}
{"token": ["Since", "histamine", "was", "suggested", "to", "be", "involved", "in", "the", "pathogenesis", "of", "stress", "ulcer", "disease", "(+)-catechin", ",", "a", "rather", "specific", "inhibitor", "of", "specific", "C1415505#ent", "<e1>", "rat", "stomach", ",", "was", "tested", "in", "C2350558#ent", "<e2>", "rats", "."], "h": {"id": "C1415505", "name": "C1415505#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [30, 31]}}
{"token": ["Small", "fragments", "derived", "from", "C0066975#ent", "<e1>", "digestion", ",", "caused", "both", "an", "acute", "edematous", "reaction", "C0003864#ent", "<e2>"], "h": {"id": "C0066975", "name": "C0066975#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [14, 15]}}
{"token": ["ICD", "therapy", "the", "primary", "and", "secondary", "prevention", "C0018802#ent", "<e1>", "which", "is", "often", "accompanied", "by", "a", "high", "risk", "C0342788#ent", "<e2>", "is", ",", "however", ",", "not", "justified", "without", "guideline-adjusted", "therapy", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0342788", "name": "C0342788#ent", "pos": [17, 18]}}
{"token": ["Recently", ",", "microvolt-level", "T", "wave", "alternans", "has", "been", "proposed", "as", "a", "new", "noninvasive", "tool", "identify", "C0018802#ent", "<e1>", "patients", "at", "risk", "for", "C0342788#ent", "<e2>", "and", "ventricular", "tachycardia/fibrillation", "VT/VF", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0342788", "name": "C0342788#ent", "pos": [21, 22]}}
{"token": ["This", "form", "of", "photochemical", "therapy", "commonly", "used", "in", "the", "treatment", "of", "psoriasis", "and", "C0042900#ent", "<e1>", ",", "but", "it", "is", "also", "beneficial", "in", "other", "C0037274#ent", "<e2>"], "h": {"id": "C0042900", "name": "C0042900#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [23, 24]}}
{"token": ["C0042900#ent", "<e1>", "is", "one", "of", "the", "most", "common", "C0037274#ent", "<e2>"], "h": {"id": "C0042900", "name": "C0042900#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [8, 9]}}
{"token": ["C0125650#ent", "<e1>", "was", "synthesized", "from", "C1161331#ent", "<e2>", "using", "bacterial", "levansucrase", "immobilized", "on", "a", "honeycomb-shaped", "ceramic", "support", "."], "h": {"id": "C0125650", "name": "C0125650#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [5, 6]}}
{"token": ["These", "were", "beta-adrenergic", "agonists", "isoproterenol", ",", "C0543495#ent", "<e1>", ")", ",", "alpha-adrenergic", "antagonists", "prazosin", ",", "ergotamine", ",", "C0724441#ent", "<e2>", ",", "phenoxybenzamine", ")", ",", "and", "calcium", "entry", "blockers", "nifedipine", ",", "verapamil", ",", "diltiazem", ")", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [16, 17]}}
{"token": ["The", "symptoms", "are", "protean", "from", "unilateral", "headache", "C0043119#ent", "<e1>", "tinnitus", ",", "to", "cerebral", "ischemia", "C0018989#ent", "<e2>", "."], "h": {"id": "C0043119", "name": "C0043119#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [14, 15]}}
{"token": ["Expression", "of", "the", "two", "myeloic", "related", "proteins", "MRP8", "and", "C1335798#ent", "<e1>", "is", "restricted", "to", "distinct", "stages", "of", "C0021345#ent", "<e2>", "differentiation", "."], "h": {"id": "C1335798", "name": "C1335798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [17, 18]}}
{"token": ["Restriction", "of", "C1335798#ent", "<e1>", "expression", "to", "only", "distinct", "pathways", "of", "C0021345#ent", "<e2>", "differentiation", "in", "HL-60", "cells", "thus", "reflect", "different", "functional", "phenotypes", "of", "monocytes/macrophages", "in", "vivo"], "h": {"id": "C1335798", "name": "C1335798#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [10, 11]}}
{"token": ["Responses", "to", "LBK", "and", "C0006945#ent", "<e1>", "were", "significantly", "reduced", "by", "C0002502#ent", "<e2>", "(", "10", "microM", ")", ",", "this", "effect", "being", "reversible", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [10, 11]}}
{"token": ["This", "increase", "in", "intracellular", "pH", "caused", "by", "C0006945#ent", "<e1>", "was", "inhibited", "by", "C0002502#ent", "<e2>", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [12, 13]}}
{"token": ["Adiponectin", "activates", "C1418776#ent", "<e1>", "PPAR-alpha", ")", ",", "a", "transcription", "factor", "regulates", "inflammation", "in", "C0023895#ent", "<e2>"], "h": {"id": "C1418776", "name": "C1418776#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [13, 14]}}
{"token": ["8", "normals", ",", "8", "asthmatics", "and", "8", "C0006277#ent", "<e1>", "inhaled", "comparable", "doses", "of", "C0027235#ent", "<e2>", "and", "salbutamol", "."], "h": {"id": "C0006277", "name": "C0006277#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0027235", "name": "C0027235#ent", "pos": [13, 14]}}
{"token": ["Cushing", "syndrome", "accelerate", "C0003850#ent", "<e1>", "by", "the", "fact", "that", "C3536709#ent", "<e2>", "may", "induce", "or", "exacerbate", "several", "known", "coronary", "risk", "factors", "hypertension", ",", "hypercholesterolemia", "and", "impaired", "glucose", "tolerance"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [9, 10]}}
{"token": ["We", "have", "previously", "shown", "that", "C1418596#ent", "<e1>", "(", "also", "called", "Ptx2", "and", "C3714873#ent", "<e2>", ")", "transactivates", "a", "reporter", "gene", "a", "bicoid", "enhancer", "synergistically", "transactivates", "the", "prolactin", "promoter", "the", "presence", "of", "the", "POU", "homeodomain", "protein", "Pit-1"], "h": {"id": "C1418596", "name": "C1418596#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C3714873", "name": "C3714873#ent", "pos": [12, 13]}}
{"token": ["C1418596#ent", "<e1>", "gene", "dose", "a", "central", "role", "in", "C3714873#ent", "<e2>"], "h": {"id": "C1418596", "name": "C1418596#ent", "pos": [0, 1]}, "relation": "gene_associated_with_disease", "t": {"id": "C3714873", "name": "C3714873#ent", "pos": [8, 9]}}
{"token": ["C0717670#ent", "<e1>", "Ontak", ")", ",", "a", "C0034857#ent", "<e2>", "diphtheria", "toxin", "ligand", ",", "IL-2", ",", "binds", "to", "the", "IL-2", "receptor", "is", "internalized", ",", "and", "causes", "cell", "death"], "h": {"id": "C0717670", "name": "C0717670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034857", "name": "C0034857#ent", "pos": [6, 7]}}
{"token": ["Here", "we", "review", "some", "of", "the", "debated", "aspects", "of", "C0913336#ent", "<e1>", "interactions", "and", "discuss", "the", "new", "and", "emerging", "roles", "of", "C1419986#ent", "<e2>", "."], "h": {"id": "C0913336", "name": "C0913336#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419986", "name": "C1419986#ent", "pos": [20, 21]}}
{"token": ["As", "such", ",", "the", "slower", "absorption", "of", "C0016860#ent", "<e1>", "in", "edematous", "states", "such", "as", "congestive", "heart", "failure", "C0023890#ent", "<e2>", ",", "does", "not", "appear", "to", "be", "a", "consequence", "of", "edema", "per", "se", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "the", "pharmacokinetics", "and", "pharmacodynamics", "of", "C0016860#ent", "<e1>", "and", "torasemide", "in", "patients", "with", "C0023890#ent", "<e2>", "and", "diuretic", "resistant", "ascites", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [14, 15]}}
{"token": ["C1415505#ent", "<e1>", "HD", ")", "and", "monoamine", "oxidase-A", "C0026455#ent", "<e2>", ")", "were", "unaffected", "after", "these", "treatments", "."], "h": {"id": "C1415505", "name": "C1415505#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026455", "name": "C0026455#ent", "pos": [7, 8]}}
{"token": ["C1705592#ent", "<e1>", "expression", "is", "regulated", "initially", "at", "the", "level", "of", "C0812327#ent", "<e2>"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [10, 11]}}
{"token": ["These", "results", "point", "to", "a", "small", "number", "of", "C3539947#ent", "<e1>", "outside", "of", "C1421429#ent", "<e2>", "and", "VR2", "that", "may", "be", "responsible", "for", "the", "particle", "defect", "enJS56A1", "Gag", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421429", "name": "C1421429#ent", "pos": [12, 13]}}
{"token": ["Some", "unresolved", "problems", "concerning", "the", "efficacy", "and", "assaying", "of", "recombinant", "factors", "future", "perspectives", "of", "both", "recombinant", "and", "plasma-derived", "C2732002#ent", "<e1>", "products", "in", "C0019069#ent", "<e2>", "are", "also", "discussed", "."], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [22, 23]}}
{"token": ["C0442893#ent", "<e1>", "may", "have", "predisposed", "these", "children", "to", "C0004610#ent", "<e2>", "identified", "in", "seven", "patients", ":", "preceding", "varicella", "infection", "four", "patients", ")", "or", "malignant", "neoplasm/immunosuppressive", "therapy", "(", "three", "patients", ")", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [8, 9]}}
{"token": ["MtN1", "is", "C1512488#ent", "<e1>", "to", "two", "small", ",", "cysteine-rich", ",", "C3539766#ent", "<e2>", "pea", "(", "pI39", "and", "pI230", ")", ",", "whereas", "MtN13", "is", "closely", "related", "to", "the", "PR10", "family", "of", "pathogenesis-related", "proteins"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539766", "name": "C3539766#ent", "pos": [10, 11]}}
{"token": ["Preliminary", "findings", "on", "C0076829#ent", "<e1>", "as", "monotherapy", "for", "partial", "C0014544#ent", "<e2>", "and", "as", "adjunctive", "therapy", "generalised", "tonic-clonic", "seizures", "non-focal", "origin", ",", "Lennox-Gastaut", "syndrome", "and", "partial", "epilepsy", "children", "have", "been", "promising", "."], "h": {"id": "C0076829", "name": "C0076829#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [9, 10]}}
{"token": ["Antiepileptic", "drugs", "be", "schematically", "classified", "according", "to", "their", "spectrum", "of", "action", "on", "generalized", "or", "partial", "epileptic", "seizures", "sodium", "valproate", "lamotrigine", ",", "benzodiazepines", "and", "C0076829#ent", "<e1>", "are", "large", "spectrum", "molecules", "are", "effective", "in", "generalized", "and", "C0014544#ent", "<e2>"], "h": {"id": "C0076829", "name": "C0076829#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [34, 35]}}
{"token": ["Two", "C1417679#ent", "<e1>", "have", "been", "identified", "in", "the", "MHC", "class", "II", "region", "C1704919#ent", "<e2>", "and", "RING11", "in", "humans", ",", "which", "are", "believed", "to", "encode", "the", "peptide", "transport", "proteins"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704919", "name": "C1704919#ent", "pos": [12, 13]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "transporters", "associated", "with", "antigen", "processing", "C1704919#ent", "<e2>", "and", "TAP2", ")", "locate", "near", "to", "HLA", "DQ", "coding", "regions", "display", "only", "a", "limited", "degree", "of", "polymorphism", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704919", "name": "C1704919#ent", "pos": [9, 10]}}
{"token": ["C3810599#ent", "<e1>", "was", "significantly", "impaired", "in", "subjects", "with", "C0011860#ent", "<e2>", "compared", "with", "control", "subjects"], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}}
{"token": ["We", "hypothesized", "that", "BH(4", ")", "would", "restore", "flow-mediated", "vasodilation", "C3810599#ent", "<e1>", ",", "endothelial-dependent", "vasodilation", ",", "which", "may", "affect", "insulin", "resistance", "C0011860#ent", "<e2>", "patients", "."], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [20, 21]}}
{"token": ["To", "explore", "functions", "of", "C0257110#ent", "<e1>", ",", "we", "disrupted", "the", "mouse", "C1335274#ent", "<e2>"], "h": {"id": "C0257110", "name": "C0257110#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335274", "name": "C1335274#ent", "pos": [11, 12]}}
{"token": ["C0257110#ent", "<e1>", "Brk", ")", ",", "also", "known", "as", "C1335274#ent", "<e2>", "is", "a", "nonreceptor", "tyrosine", "kinase", "expressed", "in", "more", "than", "60", "%", "of", "breast", "cancers"], "h": {"id": "C0257110", "name": "C0257110#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335274", "name": "C1335274#ent", "pos": [8, 9]}}
{"token": ["Breast", "tumor", "kinase", "C0257110#ent", "<e1>", ")", ",", "also", "known", "as", "C1335274#ent", "<e2>", "is", "a", "nonreceptor", "tyrosine", "kinase", "expressed", "in", "more", "than", "60", "%", "of", "breast", "cancers"], "h": {"id": "C0257110", "name": "C0257110#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335274", "name": "C1335274#ent", "pos": [10, 11]}}
{"token": ["injection", "of", "collagen", "plus", "epinephrine", ",", "of", "9,11-dideoxy-11alpha", ",", "9alpha-epoxymethano-prostaglandin", "F(2alpha", ")", "(", "C0917834#ent", "<e1>", ")", "and", "of", "C1414504#ent", "<e2>", "while", "aspirin", "was", "only", "active", "against", "collagen", "plus", "epinephrine", "."], "h": {"id": "C0917834", "name": "C0917834#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [18, 19]}}
{"token": ["The", "initial", "[Ca2+]i", "peak", "in", "response", "to", "C0917834#ent", "<e1>", "was", "about", "half", "of", "C1414504#ent", "<e2>"], "h": {"id": "C0917834", "name": "C0917834#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [13, 14]}}
{"token": ["C1327830#ent", "<e1>", "is", "an", "oral", "ATP-competitive", "inhibitor", "of", "the", "C0257291#ent", "<e2>"], "h": {"id": "C1327830", "name": "C1327830#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0257291", "name": "C0257291#ent", "pos": [9, 10]}}
{"token": ["We", "investigated", "the", "topographic", "expression", "of", "MUC5AC", "and", "C1417499#ent", "<e1>", "in", "relationship", "with", "C0012634#ent", "<e2>"], "h": {"id": "C1417499", "name": "C1417499#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}}
{"token": ["From", "pathological", "point", "of", "view", "the", "chronic", "renal", "infections", "two", "types", ",", "interstitial", "chronic", "pyelonephritis", "C0034188#ent", "<e1>", "namely", "xanthogranulomatous", ",", "malacoplakia", "and", "C0041328#ent", "<e2>"], "h": {"id": "C0034188", "name": "C0034188#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041328", "name": "C0041328#ent", "pos": [22, 23]}}
{"token": ["C1705725#ent", "<e1>", "induced", "activation", "of", "C1706144#ent", "<e2>", "over", "a", "similar", "time", "course"], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706144", "name": "C1706144#ent", "pos": [5, 6]}}
{"token": ["A", "fragment", "of", "C1419524#ent", "<e1>", "containing", "the", "box", "B/C", "motif", "is", "not", "localized", "to", "C1417613#ent", "<e2>", "but", "retained", "in", "coiled", "bodies"], "h": {"id": "C1419524", "name": "C1419524#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "in", "contrast", "to", "snoRNAs", "like", "C1419524#ent", "<e1>", ",", "U6", "snRNA", "passes", "through", "C1417613#ent", "<e2>", "."], "h": {"id": "C1419524", "name": "C1419524#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [14, 15]}}
{"token": ["C1419524#ent", "<e1>", "and", "U8", "RNAs", "containing", "alternative", "cap", "structures", "not", "localize", "in", "C1417613#ent", "<e2>", "nor", "did", "C1419524#ent", "<e1>", "or", "U8", "RNAs", "containing", "triphosphate", "5'-termini", "."], "h": {"id": "C1419524", "name": "C1419524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "interpretations", "of", "allelic", "association", "with", "C0033860#ent", "<e1>", "are", "compounded", "by", "limited", "insight", "of", "C1539521#ent", "<e2>", "conservation", "within", "MHC", "class", "I", "interval"], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539521", "name": "C1539521#ent", "pos": [15, 16]}}
{"token": ["Binding", "of", "C1720860#ent", "<e1>", "to", "the", "antibody", "support", ",", "however", ",", "rendered", "the", "C0014442#ent", "<e2>", "remarkably", "labile", "to", "high", "temperatures", "and", "storage", "."], "h": {"id": "C1720860", "name": "C1720860#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "emerging", "evidence", "show", "that", "C0012739#ent", "<e1>", "and", "hyperhomo-cysteinemia", "may", "be", "responsible", "for", "C0154839#ent", "<e2>"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0154839", "name": "C0154839#ent", "pos": [14, 15]}}
{"token": ["A", "31-year-old", "man", "with", "C0038013#ent", "<e1>", "who", "had", "previously", "been", "treated", "with", "C0038792#ent", "<e2>", ",", "fenoprofen", "calcium", "high", "dose", "salicylates", "and", "gold", "salts", "developed", "renal", "papillary", "necrosis", "RPN", ")", "4", "months", "after", "institution", "of", "naproxen", "therapy"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [12, 13]}}
{"token": ["Three", "C0072402#ent", "<e1>", "phosphorylate", "the", "CTD", "of", "C0035680#ent", "<e2>", "been", "identified", "in", "Aspergillus", "nidulans"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [7, 8]}}
{"token": ["All", "mucopolysaccharidosis", "are", "autosomal", "recessive", "disorders", "except", "for", "C1415882#ent", "<e1>", "is", "X-linked", "and", "C0017361#ent", "<e2>", "."], "h": {"id": "C1415882", "name": "C1415882#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [13, 14]}}
{"token": ["Mucopolysaccharidosis", "type", "II", "MPS", "II", "C1415882#ent", "<e1>", "is", "an", "X-chromosome-linked", "C0017361#ent", "<e2>", "lysosomal", "storage", "disorder", "results", "from", "a", "deficiency", "of", "iduronate-2-sulphatase", "(", "12S", ")", "."], "h": {"id": "C1415882", "name": "C1415882#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [10, 11]}}
{"token": ["In", "variegate", "porphyria", "C1418819#ent", "<e1>", "which", "catalyzes", "the", "oxidation", "of", "C0072500#ent", "<e2>", "to", "protoporphyrin", ",", "appears", "to", "be", "defective", "."], "h": {"id": "C1418819", "name": "C1418819#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072500", "name": "C0072500#ent", "pos": [10, 11]}}
{"token": ["Proadrenomedullin", "N-terminal", "20", "peptide", "PAMP", ")", "and", "adrenomedullin", "(", "C1426677#ent", "<e1>", ")", ",", "which", "are", "both", "derived", "from", "C0257634#ent", "<e2>", ",", "exhibit", "marked", "hypotensive", "effects", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0257634", "name": "C0257634#ent", "pos": [18, 19]}}
{"token": ["The", "conditioned", "media", "from", "C1333690#ent", "<e1>", "LYM", ",", "and", "MTLn2", "tumor", "cells", "or", "without", "C0041236#ent", "<e2>", "activation", "contained", "low", "levels", "of", "interstitial-type", "collagenolytic", "activity", "made", "no", "significant", "contribution", "to", "the", "collagenolytic", "activity", "the", "stimulated", "fibroblasts", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [14, 15]}}
{"token": ["In", "asymptomatic", "patients", ",", "most", "early", "esophageal", "carcinomas", "detected", "during", "the", "follow-up", "of", "C0038354#ent", "<e1>", "mass-screening", "or", "medical", "examination", "gastric", "cancer", "and", "in", "connection", "with", "C0000737#ent", "<e2>", "to", "other", "diseases", "."], "h": {"id": "C0038354", "name": "C0038354#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [25, 26]}}
{"token": ["4-Hydroxy", "C0039286#ent", "<e1>", "had", "anti-estrogenic", "activity", "in", "yeast", "lacking", "the", "transporter", "C1336644#ent", "<e2>", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1336644", "name": "C1336644#ent", "pos": [11, 12]}}
{"token": ["C0049561#ent", "<e1>", "(", "EOE", ")", "and", "its", "enantiomers", "were", "compared", "with", "C0003596#ent", "<e2>", "in", "a", "number", "of", "tests", "designed", "to", "measure", "dopamine", "(", "DA", ")", "agonist", "activity", "within", "the", "central", "nervous", "system"], "h": {"id": "C0049561", "name": "C0049561#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [11, 12]}}
{"token": ["We", "show", "here", "that", "C3812165#ent", "<e1>", "is", "also", "expressed", "in", "multiple", "cancers", "is", "thus", "itself", "a", "C1422072#ent", "<e2>", "that", "conditional", "expression", "of", "C3812165#ent", "<e1>", "in", "normal", "fibroblasts", "activates", "cancer-testis", "genes", "."], "h": {"id": "C1422072", "name": "C1422072#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3812165", "name": "C3812165#ent", "pos": [4, 5]}}
{"token": ["This", "includes", "C1569775#ent", "<e1>", "well", "as", "several", "modulators", "of", "the", "tau", "protein", "other", "AD-relevant", "C1417679#ent", "<e2>", "and", "proteins", "."], "h": {"id": "C1569775", "name": "C1569775#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}}
{"token": ["C1420453#ent", "<e1>", "StAR", ")", "and", "peripheral-type", "benzodiazepine", "receptor", "C1823521#ent", "<e2>", ")", "have", "both", "been", "implicated", "in", "the", "transport", "of", "cholesterol", "across", "mitochondrial", "membranes", "steroidogenic", "cells", "."], "h": {"id": "C1420453", "name": "C1420453#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [8, 9]}}
{"token": ["C1420453#ent", "<e1>", "StAR", ")", "and", "peripheral-type", "benzodiazepine", "receptor", "C1823521#ent", "<e2>", ")", "have", "been", "implicated", "in", "this", "rate-determining", "step", "of", "steroidogenesis", "."], "h": {"id": "C1420453", "name": "C1420453#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [8, 9]}}
{"token": ["The", "time", "reached", "the", "peak", "were", "IL-6", ",", "CRP", ",", "C1705002#ent", "<e1>", ",", "AAT", ",", "AMG", ",", "C1417239#ent", "<e2>", ",", "HAP", "reached", "the", "peak", "in", "that", "order", "."], "h": {"id": "C1705002", "name": "C1705002#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417239", "name": "C1417239#ent", "pos": [17, 18]}}
{"token": ["Src", "family", "tyrosine", "kinases", "Blk", "Fyn", ",", "C0919477#ent", "<e1>", ",", "and", "Lyn", "as", "well", "as", "spleen", "kinase", "C1335892#ent", "<e2>", ",", "are", "activated", "to", "transmit", "the", "signal", "further", "."], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [17, 18]}}
{"token": ["In", "intact", "cells", "the", "binding", "of", "the", "SH2", "domain", "C0919477#ent", "<e1>", "correlated", "with", "the", "ability", "of", "C1335892#ent", "<e2>", "to", "induce", "tyrosine", "phosphorylation", "cellular", "proteins"], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [16, 17]}}
{"token": ["T-cell", "antigen", "receptor", "TCR", ")", "engagement", "results", "in", "sequential", "activation", "of", "the", "Src", "protein", "tyrosine", "kinases", "PTKs", ")", "C0919477#ent", "<e1>", "and", "Fyn", "and", "the", "Syk", "PTKs", ",", "ZAP-70", "and", "C1335892#ent", "<e2>", "."], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [29, 30]}}
{"token": ["We", "used", "cDNA", "microarrays", "1500", "C1335222#ent", "<e1>", "cDNAs", "to", "profile", "transcripts", "regulated", "by", "C0002842#ent", "<e2>", "in", "prostate", "cancer", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [13, 14]}}
{"token": ["Macular", "amyloidosis", "MA", ")", "and", "lichen", "amyloidosus", "C1420423#ent", "<e1>", ")", "are", "the", "two", "major", "variants", "of", "the", "C0268397#ent", "<e2>", "present", "with", "severe", "and", "therapy", "resistant", "itching", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268397", "name": "C0268397#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "rate", "of", "erosions", "and", "ulcers", "of", "the", "C0030920#ent", "<e1>", "UGDT", ")", "in", "patients", "treated", "with", "C0085387#ent", "<e2>", "C-NAID", ")", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [17, 18]}}
{"token": ["C0030920#ent", "<e1>", "lesions", "occurred", "with", "the", "C0085387#ent", "<e2>", "indomethacin", ")", "(", "Indocid", "capsules", "or", "5", "mg", "kg(-1", ")", "day(-1", ")", "b.i.d", ".", ")", ","], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [6, 7]}}
{"token": ["By", "sparing", "COX-1", ",", "COX-2", "specific", "inhibitors", "provide", "effective", "anti-inflammatory", "and", "analgesic", "activity", "substantially", "reducing", "the", "risk", "of", "C0030920#ent", "<e1>", "GI", "bleeding", "to", "dual", "C0085387#ent", "<e2>", "traditional", "NSAIDs", ")", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [24, 25]}}
{"token": ["DPC4", "and", "C1704789#ent", "<e1>", ",", "putative", "tumor", "suppressor", "genes", "in", "the", "C1414672#ent", "<e2>", "of", "several", "types", "of", "human", "cancer", "lie", "on", "the", "long", "arm", "human", "chromosome", "18", "."], "h": {"id": "C1704789", "name": "C1704789#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [11, 12]}}
{"token": ["Neuropathy", "Target", "C1257646#ent", "<e1>", "(", "NTE", ")", "is", "the", "molecular", "target", "the", "nervous", "system", "C0163401#ent", "<e2>", "OP", ")", "when", "they", "cause", "delayed", "polyneuropathy", "."], "h": {"id": "C1257646", "name": "C1257646#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0163401", "name": "C0163401#ent", "pos": [14, 15]}}
{"token": ["These", "pretreatments", "did", "not", "affect", "cholinesterase", ",", "nonspecific", "C1257646#ent", "<e1>", ",", "or", "plasma", "C0163401#ent", "<e2>", "activities", "."], "h": {"id": "C1257646", "name": "C1257646#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0163401", "name": "C0163401#ent", "pos": [13, 14]}}
{"token": ["We", "also", "measured", "the", "levels", "of", "expression", "of", "C1424660#ent", "<e1>", ",", "51kDa", ",", "and", "75kDa", "mRNA", "associated", "with", "genes", "encoding", "C0171406#ent", "<e2>", "complex", "I", "that", "of", "alpha", "cardiac", "myosin", "heavy", "chain", "mRNA", "in", "both", "groups", "."], "h": {"id": "C1424660", "name": "C1424660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [20, 21]}}
{"token": ["The", "mechanism", "of", "action", "of", "the", "assay", "requires", "the", "binding", "of", "C1428200#ent", "<e1>", "to", "a", "double-stranded", "DNA", "oligonucleotide", "to", "the", "active", "C0027203#ent", "<e2>", "."], "h": {"id": "C1428200", "name": "C1428200#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [21, 22]}}
{"token": ["On", "the", "contrary", ",", "recombinant", "nonisoprenylated", "C0084340#ent", "<e1>", "failed", "to", "activate", "the", "C0388638#ent", "<e2>", "."], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [12, 13]}}
{"token": ["Recently", ",", "diabetes", "mellitus", "divided", "into", "four", "distinct", "types", "(", "type", "1", "diabetes", "type", "2", "diabetes", "other", "specific", "types", "of", "diabetes", "and", "C0085207#ent", "<e1>", "in", "the", "Report", "of", "the", "Expert", "Committee", "the", "Diagnosis", "and", "C3829989#ent", "<e2>", "USA", "."], "h": {"id": "C0085207", "name": "C0085207#ent", "pos": [22, 23]}, "relation": "nichd_parent_of", "t": {"id": "C3829989", "name": "C3829989#ent", "pos": [34, 35]}}
{"token": ["The", "C2936489#ent", "<e1>", "afsB", ",", "from", "Streptomyces", "coelicolor", "A3(2", ",", "possibly", "encoding", "a", "C0812382#ent", "<e2>", "is", "required", "for", "actinorhodin", "production", "in", "this", "organism", "."], "h": {"id": "C2936489", "name": "C2936489#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [13, 14]}}
{"token": ["Blood", "samples", "collected", "from", "10", "C0004096#ent", "<e1>", "patients", "before", "and", "2", "weeks", "after", "standard", "C0081408#ent", "<e2>", "treatment", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0081408", "name": "C0081408#ent", "pos": [14, 15]}}
{"token": ["There", "was", "a", "trend", "for", "the", "early", "C0004096#ent", "<e1>", "response", "to", "be", "less", "on", "the", "day", "of", "C0081408#ent", "<e2>", "treatment", ",", "but", "this", "did", "not", "reach", "statistical", "significance", "p", "=", "0.08", ")", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0081408", "name": "C0081408#ent", "pos": [17, 18]}}
{"token": ["The", "apparent", "Km", "for", "the", "structurally", "related", "C0038761#ent", "<e1>", "antibiotic", "dapsone", "5-fold", "lower", "for", "the", "slow", "variant", "C1261253#ent", "<e2>", "compared", "with", "the", "wild-type", "NAT2", "4"], "h": {"id": "C0038761", "name": "C0038761#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1261253", "name": "C1261253#ent", "pos": [17, 18]}}
{"token": ["C0018995#ent", "<e1>", "is", "a", "C0019247#ent", "<e2>", "diagnosis", "and", "early", "therapy", "which", "is", "particularly", "relevant", "to", "prevent", "the", "appearance", "of", "complications", "."], "h": {"id": "C0018995", "name": "C0018995#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [4, 5]}}
{"token": ["The", "presence", "of", "a", "specific", "immune", "response", "an", "C0014442#ent", "<e1>", "that", "has", "been", "associated", "with", "C0001175#ent", "<e2>", "intriguing", "possibilities", "concerning", "the", "relationship", "between", "DNA", "damage", "immunodeficiency", ",", "and", "autoimmunity", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [15, 16]}}
{"token": ["These", "emergencies", "include", "asystole", ",", "C0264490#ent", "<e1>", "anaphylaxis", ",", "shock", ",", "myocardial", "infarction", "cardiac", "arrhythmias", "C0751495#ent", "<e2>", "due", "to", "several", "common", "causes", ",", "and", "rapid", "sequence", "anesthesia", "induction", "."], "h": {"id": "C0264490", "name": "C0264490#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [15, 16]}}
{"token": ["Specifically", ",", "C1705438#ent", "<e1>", "binds", "to", "a", "perfect", "palindromic", "motif", "in", "the", "C3811813#ent", "<e2>", "promoter", "."], "h": {"id": "C1705438", "name": "C1705438#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3811813", "name": "C3811813#ent", "pos": [12, 13]}}
{"token": ["We", "report", "here", "that", "C1705438#ent", "<e1>", "acts", "as", "a", "transcriptional", "regulator", "C3811813#ent", "<e2>", "(", "MAPK", "phosphatase-2", ",", "a", "dual", "specificity", "protein", "phosphatase", "DUSP4", ")", "with", "stringent", "substrate", "specificity", "for", "MAPKs", "."], "h": {"id": "C1705438", "name": "C1705438#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3811813", "name": "C3811813#ent", "pos": [11, 12]}}
{"token": ["The", "major", "component", "of", "C1417699#ent", "<e1>", "is", "a", "45", "K", "polypeptide", "designated", "C2985445#ent", "<e2>", "that", "belongs", "to", "the", "basic", "region-leucine", "zipper", "family", "of", "transcription", "factors"], "h": {"id": "C1417699", "name": "C1417699#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2985445", "name": "C2985445#ent", "pos": [12, 13]}}
{"token": ["The", "C1417699#ent", "<e1>", "binds", "these", "sites", "is", "a", "heterodimeric", "basic", "leucine", "zipper", "protein", "of", "a", "tissue-specific", "subunit", "C2985445#ent", "<e2>", "and", "a", "smaller", "subunit", ",", "p18", "NF-E2", "that", "is", "widely", "expressed", "."], "h": {"id": "C1417699", "name": "C1417699#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2985445", "name": "C2985445#ent", "pos": [17, 18]}}
{"token": ["C1428430#ent", "<e1>", "is", "induced", "in", "response", "both", "to", "hypoxia", "and", "energy", "stress", "and", "cells", "that", "lack", "C1428430#ent", "<e1>", "exhibit", "highly", "defective", "C0076836#ent", "<e1>", "regulation", "in", "response", "to", "either", "of", "these", "stress", "signals", "."], "h": {"id": "C1428430", "name": "C1428430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0076836", "name": "C0076836#ent", "pos": [21, 22]}}
{"token": ["Several", "recent", "reports", "have", "identified", "the", "stress", "response", "gene", "C1428430#ent", "<e1>", "as", "an", "essential", "regulator", "of", "C0076836#ent", "<e2>", "activity", "through", "the", "TSC1/2", "complex", "in", "both", "Drosophila", "and", "mammalian", "cells"], "h": {"id": "C1428430", "name": "C1428430#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0076836", "name": "C0076836#ent", "pos": [16, 17]}}
{"token": ["The", "C0024727#ent", "<e1>", "glycopeptide", "contains", "high-molecular-weight", "mannan", "C0019139#ent", "<e2>", "oligosaccharide", "units", "of", "mannose", "."], "h": {"id": "C0024727", "name": "C0024727#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [7, 8]}}
{"token": ["We", "used", "HDAC", "(", "C1333891#ent", "<e1>", "inhibition", "and", "C1420492#ent", "<e2>", "(", "chromatin", "immunoprecipitation", "analyses", "to", "define", "regions", "associated", "with", "acute", "acetylation", "histone", "at", "the", "CFTR", "locus", "."], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420492", "name": "C1420492#ent", "pos": [8, 9]}}
{"token": ["A", "25", "kDa", "subunit", "of", "C0017837#ent", "<e1>", "GST", ")", "from", "sheep", "liver", "microsomes", "(", "microsomal", "C1436224#ent", "<e2>", "-", "1", ")", "with", "a", "significant", "selenium-independent", "glutathione", "peroxidase", "activity", "has", "been", "isolated", "and", "characterized", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1436224", "name": "C1436224#ent", "pos": [15, 16]}}
{"token": ["A", "cluster", "of", "three", "C0017837#ent", "<e1>", "designated", "GSTA", ",", "C1436224#ent", "<e2>", "and", "GSTA2", ",", "was", "isolated", "from", "the", "marine", "flatfish", "plaice", "(", "Pleuronectes", "platessa", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1436224", "name": "C1436224#ent", "pos": [9, 10]}}
{"token": ["Thus", "it", "is", "apparent", "that", "intake", "of", "the", "tumorigenic", "CD", "diet", "by", "male", "rats", "results", "in", "the", "feminization", "of", "C0017837#ent", "<e1>", "activity", ",", "whereas", "in", "females", "C1436224#ent", "<e2>", "upregulated", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [19, 20]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1436224", "name": "C1436224#ent", "pos": [26, 27]}}
{"token": ["In", "addition", ",", "antibody", "activity", "C1334043#ent", "<e1>", "not", "be", "absorbed", "by", "C0003864#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [11, 12]}}
{"token": ["We", "have", "investigated", "linkage", "to", "five", "regions", "C1334043#ent", "<e1>", "to", "those", "identified", "in", "animal", "models", "C0003864#ent", "<e2>", "RA", "affected", "sibling", "pair", "ASP", ")", "families", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [15, 16]}}
{"token": ["Once", "high", "levels", "of", "C-1", "-", "11", "borreliacidal", "antibody", "developed", ",", "hamsters", "were", "protected", "from", "C1334043#ent", "<e1>", "development", "of", "C0003864#ent", "<e2>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [19, 20]}}
{"token": ["Cortical", "treatment", "KCl", "induced", "an", "upregulation", "of", "C0033640#ent", "<e1>", "and", "zeta", "messenger", "RNA", "4", "and", "8", "h", ",", "whereas", "C1142812#ent", "<e2>", "beta", ",", "gamma", "and", "epsilon", "did", "not", "show", "significant", "changes", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1142812", "name": "C1142812#ent", "pos": [19, 20]}}
{"token": ["The", "amount", "of", "MMA", "extracted", "during", "3", "weeks", "in", "C0001962#ent", "<e1>", "was", "smaller", "for", "the", "C1420627#ent", "<e2>", ",", "but", "the", "total", "amount", "of", "released", "monomers", "was", "larger", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420627", "name": "C1420627#ent", "pos": [15, 16]}}
{"token": ["A", "history", "of", "parental", "tonsillectomy", "and", "a", "family", "history", "atopy", "are", "both", "significant", "predictive", "factors", "the", "number", "of", "reported", "C0242429#ent", "<e1>", "episodes", "of", "C0040425#ent", "<e2>", "in", "children", "."], "h": {"id": "C0242429", "name": "C0242429#ent", "pos": [19, 20]}, "relation": "related_to", "t": {"id": "C0040425", "name": "C0040425#ent", "pos": [23, 24]}}
{"token": ["Strains", "of", "S.", "aureus", "H.", "influenzae", "were", "isolated", "from", "the", "C0242429#ent", "<e1>", "of", "41", "children", "suffering", "from", "successive", "acute", "pharyngitis", "C0040425#ent", "<e2>", "were", "compared", "."], "h": {"id": "C0242429", "name": "C0242429#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0040425", "name": "C0040425#ent", "pos": [20, 21]}}
{"token": ["We", "identified", "AtRING1a", "and", "AtRING1b", "as", "C4277608#ent", "<e1>", "of", "the", "animal", "PRC1", "core", "component", "C1419389#ent", "<e2>", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419389", "name": "C1419389#ent", "pos": [14, 15]}}
{"token": ["Depending", "on", "the", "levels", "of", "auxiliary", "proteins", "C0012920#ent", "<e1>", "protein", "HU", ",", "three", "priming", "systems", "can", "operate", ":", "C0058594#ent", "<e2>", "alone", ",", "RNA", "pol", ",", "or", "both", "combined", "."], "h": {"id": "C0012920", "name": "C0012920#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0058594", "name": "C0058594#ent", "pos": [18, 19]}}
{"token": ["Given", "that", "C1307407#ent", "<e1>", "inhibitors", "failed", "to", "increase", "Mnk", "and", "C1414351#ent", "<e2>", "phosphorylation", "in", "phosphatidylinositol", "3-kinase", "cells", ",", "we", "conclude", "that", "C1307407#ent", "<e1>", "inhibition", "increases", "C1414351#ent", "<e2>", "phosphorylation", "through", "a", "PI3K-dependent", "and", "Mnk-mediated", "mechanism", "."], "h": {"id": "C1414351", "name": "C1414351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1307407", "name": "C1307407#ent", "pos": [2, 3]}}
{"token": ["C1414351#ent", "<e1>", ",", "a", "translational", "regulator", "acts", "downstream", "of", "Akt", "and", "C1307407#ent", "<e2>", ",", "recapitulates", "Akt", "'s", "action", "in", "tumorigenesis", "and", "drug", "resistance", "but", "is", "unable", "to", "confer", "sensitivity", "to", "rapamycin", "and", "chemotherapy", "."], "h": {"id": "C1414351", "name": "C1414351#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1307407", "name": "C1307407#ent", "pos": [11, 12]}}
{"token": ["Perioperative", "ventricular", "tachycardia", "VT", ")", "was", "treated", "with", "C0171476#ent", "<e1>", "a", "pure", "C4284015#ent", "<e2>", "2", "patients", "with", "low", "left", "ventricular", "ejection", "fraction", "LVEF", ")", "."], "h": {"id": "C0171476", "name": "C0171476#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284015", "name": "C4284015#ent", "pos": [12, 13]}}
{"token": ["Kynurenine", "aminotransferase", "I", "KAT-I", ")", ",", "which", "also", "shows", "glutamine", "transaminase", "K", "C1705658#ent", "<e1>", ")", "activity", ",", "catalyses", "the", "conversion", "of", "C0242369#ent", "<e2>", "to", "kynurenic", "acid", "an", "endogenous", "glutamate", "antagonist"], "h": {"id": "C1705658", "name": "C1705658#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242369", "name": "C0242369#ent", "pos": [21, 22]}}
{"token": ["Summary", "Objective", "Hypocalcaemia", "is", "a", "common", "finding", "in", "horses", "with", "C0014356#ent", "<e1>", "and", "severe", "C0017178#ent", "<e2>"], "h": {"id": "C0014356", "name": "C0014356#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [14, 15]}}
{"token": ["C1421222#ent", "<e1>", "(", "also", "called", "C3711784#ent", "<e2>", ")", "is", "a", "major", "protein", "in", "sarcomere", "assembly", "as", "well", "as", "providing", "elastic", "return", "of", "the", "sarcomere", "postcontraction", "in", "cardiac", "and", "striated", "skeletal", "muscle", "tissues", "."], "h": {"id": "C1421222", "name": "C1421222#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3711784", "name": "C3711784#ent", "pos": [5, 6]}}
{"token": ["ST2", "supports", "B", "lymphopoiesis", "and", "C1413868#ent", "<e1>", "maintains", "B", "progenitors", "do", "not", "express", "a", "B-lineage", "antigen", "(", "C1335285#ent", "<e2>", ")", ",", "but", "does", "not", "allow", "their", "further", "differentiation", "into", "C1335285#ent", "<e2>", "+", "B-lineage", "cells", "."], "h": {"id": "C1413868", "name": "C1413868#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335285", "name": "C1335285#ent", "pos": [17, 18]}}
{"token": ["The", "optic", "disc", "studied", "by", "stereofluorescein", "angiography", "7", "cases", "of", "the", "chronic", "stage", "C0155305#ent", "<e1>", "AION", ")", "and", "20", "cases", "of", "C0152136#ent", "<e2>", "LTG", ")", ",", "to", "clarify", "the", "difference", "in", "vasculature", "."], "h": {"id": "C0155305", "name": "C0155305#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0152136", "name": "C0152136#ent", "pos": [21, 22]}}
{"token": ["Because", "many", "protein", "binding", "enzyme", "activities", "directed", "towards", "peptides", ",", "the", "preparation", "of", "arrays", "having", "hundreds", "to", "thousands", "of", "C2350558#ent", "<e1>", "peptides", "offers", "an", "unprecedented", "opportunity", "for", "identifying", "interactions", "of", "C0086376#ent", "<e2>", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [30, 31]}}
{"token": ["In", "conclusion", ",", "photoreactive", "pullulan", "was", "covalently", "C2350558#ent", "<e1>", "on", "various", "surfaces", "and", "tended", "to", "reduce", "interactions", "with", "C0086376#ent", "<e2>", "and", "cells", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [18, 19]}}
{"token": ["C0041484#ent", "<e1>", "have", "been", "reported", "to", "occur", "frequently", "in", "patients", "with", "C1847835#ent", "<e2>", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1847835", "name": "C1847835#ent", "pos": [11, 12]}}
{"token": ["Chronic", "stable", "angina", "C0751039#ent", "<e1>", ")", "is", "a", "major", "C3714552#ent", "<e2>", "health", "problem", "Canada", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [9, 10]}}
{"token": ["Mutation", "of", "Gab1", "Tyr627", "to", "phenylalanine", "(", "YF-Gab1", ")", "to", "prevent", "the", "binding", "of", "C1706044#ent", "<e1>", "completely", "prevented", "the", "shear", "stress-induced", "phosphorylation", "C1328053#ent", "<e2>", ",", "leaving", "the", "Akt", "response", "intact", "."], "h": {"id": "C1706044", "name": "C1706044#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [22, 23]}}
{"token": ["A", "dominant-negative", "C1706044#ent", "<e1>", "mutant", "prevented", "the", "activation", "of", "PKA", "and", "phosphorylation", "of", "C1328053#ent", "<e2>", "without", "affecting", "that", "of", "Akt", "."], "h": {"id": "C1706044", "name": "C1706044#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [13, 14]}}
{"token": ["The", "changes", "in", "lipoproteins", "induced", "by", "lovastatin", "(", "L", ")", "and", "C0033215#ent", "<e1>", "(", "P", ")", "were", "compared", "in", "patients", "with", "C0020443#ent", "<e2>"], "h": {"id": "C0033215", "name": "C0033215#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [21, 22]}}
{"token": ["To", "investigate", "the", "effect", "of", "C0033215#ent", "<e1>", "and", "losartan", "on", "the", "prevention", "of", "restenosis", "after", "balloon", "angioplasty", "C0020443#ent", "<e2>", "and", "to", "examine", "the", "expression", "of", "growth", "factors"], "h": {"id": "C0033215", "name": "C0033215#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [17, 18]}}
{"token": ["A", "multicenter", "study", "undertaken", "to", "compare", "the", "effects", "of", "lovastatin", "(", "given", "in", "4", "different", "dosage", "regimens", ")", "and", "C0033215#ent", "<e1>", "in", "patients", "with", "severe", "C0020443#ent", "<e2>"], "h": {"id": "C0033215", "name": "C0033215#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [25, 26]}}
{"token": ["A", "separate", "structural", "alignment", "of", "HIV-1", ",", "C0037207#ent", "<e1>", "SIV", ")", ",", "and", "avian", "sarcoma", "virus", "C3491974#ent", "<e2>", ")", "INs", "predicted", "which", "of", "these", "residues", "were", "unique", "."], "h": {"id": "C0037207", "name": "C0037207#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3491974", "name": "C3491974#ent", "pos": [16, 17]}}
{"token": ["Sucrase", "and", "C0002272#ent", "<e1>", "activities", "of", "C1527037#ent", "<e2>", "rats", "were", "significantly", "lower", "than", "C", "rats", "in", "the", "three", "mucosal", "regions"], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1527037", "name": "C1527037#ent", "pos": [6, 7]}}
{"token": ["Cytochemical", "characteristics", "strongly", "positive", "reactions", "for", "nonspecific", "C0014894#ent", "<e1>", ",", "inhibited", "by", "C3541971#ent", "<e2>", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541971", "name": "C3541971#ent", "pos": [12, 13]}}
{"token": ["Intense", "activity", "of", "nonspecific", "C0014894#ent", "<e1>", "that", "is", "inhibited", "by", "C3541971#ent", "<e2>", "is", "characteristic", "of", "cells", "of", "monocytic", "or", "reticulum", "cell", "origin"], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541971", "name": "C3541971#ent", "pos": [10, 11]}}
{"token": ["Identification", "of", "type", "of", "leukemia", "using", "the", "FAB", "classification", ",", "was", "based", "on", "morphology", "and", "special", "stains", "including", "myeloperoxidase", ",", "Sudan", "black", "B", "periodic", "acid-Schiff", "nonspecific", "C0014894#ent", "<e1>", "with", "and", "without", "inhibition", "by", "C3541971#ent", "<e2>", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3541971", "name": "C3541971#ent", "pos": [33, 34]}}
{"token": ["An", "otherwise", "unexplained", "low", "frequency", "ABG", "in", "patients", "with", "C0025281#ent", "<e1>", "the", "possibility", "of", "an", "\"", "inner", "ear", "C0018777#ent", "<e2>"], "h": {"id": "C0025281", "name": "C0025281#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018777", "name": "C0018777#ent", "pos": [18, 19]}}
{"token": ["Here", "we", "have", "used", "C1412056#ent", "<e1>", "vectors", "to", "inactivate", "mutant", "C1332773#ent", "<e2>", "OI", "MSCs", ",", "thereby", "demonstrating", "that", "both", "type", "I", "collagen", "genes", "for", "OI", "can", "be", "successfully", "targeted", "."], "h": {"id": "C1412056", "name": "C1412056#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332773", "name": "C1332773#ent", "pos": [10, 11]}}
{"token": ["Salivary", "MALT", "lymphomas", "typically", "associated", "with", "sialadenitis", "(", "C1704805#ent", "<e1>", ")", "in", "a", "patient", "with", "or", "without", "C0151449#ent", "<e2>"], "h": {"id": "C1704805", "name": "C1704805#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [17, 18]}}
{"token": ["The", "course", "and", "development", "of", "atopic", "symptoms", "were", "followed", "up", "in", "801", "C0011615#ent", "<e1>", "patients", ",", "in", "207", "C2607914#ent", "<e2>", "asthma", "patients", ",", "and", "in", "517", "control", "subjects"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C2607914", "name": "C2607914#ent", "pos": [18, 19]}}
{"token": ["The", "value", "of", "C1456796#ent", "<e1>", "and", "the", "soluble", "circulating", "fragment", "of", "C1456796#ent", "<e1>", "(", "C3641673#ent", "<e1>", ")", "for", "atopic", "dermatitis", "AD", ")", "remains", "unclear", "."], "h": {"id": "C1456796", "name": "C1456796#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3641673", "name": "C3641673#ent", "pos": [14, 15]}}
{"token": ["Low", "serum", "levels", "of", "soluble", "C1456796#ent", "<e1>", "were", "found", "in", "healthy", "humans", ",", "whereas", "increased", "C3641673#ent", "<e2>", "serum", "concentrations", "were", "detected", "under", "pathophysiological", "situations", "such", "as", "systemic", "lupus", "erythematosus", "rheumatoid", "arthritis", "certain", "viral", "infections", "adult", "T", "cell", "leukaemia/lymphoma"], "h": {"id": "C1456796", "name": "C1456796#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3641673", "name": "C3641673#ent", "pos": [15, 16]}}
{"token": ["C0162745#ent", "<e1>", "is", "a", "proteolytic", "enzyme", "as", "one", "of", "the", "matrix", "metalloproteinases", "C2001899#ent", "<e2>", ")", "that", "specifically", "recognizes", "and", "cleaves", "collagen", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [12, 13]}}
{"token": ["Previously", "unknown", "splice", "variants", "C1336556#ent", "<e1>", "and", "an", "uncharacterised", "C0017337#ent", "<e2>", "Ga50", "were", "identified", "."], "h": {"id": "C1336556", "name": "C1336556#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["Treatment", "of", "C0155583#ent", "<e1>", "often", "a", "complex", "C0310298#ent", "<e2>", "and", "needs", "appropriate", "methodology", "."], "h": {"id": "C0155583", "name": "C0155583#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [7, 8]}}
{"token": ["Operated", "at", "a", "10-hour", "hydraulic", "retention", "time", "and", "20-day", "solids", "residence", "time", ",", "the", "C4049614#ent", "<e1>", "outperformed", "the", "SBR", "and", "sand", "filtration", "C1337096#ent", "<e2>", "and", "suspended", "solids", "removal", "."], "h": {"id": "C4049614", "name": "C4049614#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337096", "name": "C1337096#ent", "pos": [22, 23]}}
{"token": ["The", "C1366496#ent", "<e1>", "controlling", "fruiting", "body", "development", "the", "homothallic", "ascomycete", "Sordaria", "macrospora", "encodes", "a", "C1419009#ent", "<e2>", "zinc", "finger", "protein", "a", "typical", "DNA", "binding", "domain", "GAL4-like", "C6", "zinc", "finger", "proteins", "as", "well", "as", "a", "putative", "nuclear", "targeting", "signal", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419009", "name": "C1419009#ent", "pos": [14, 15]}}
{"token": ["An", "intact", "C0032002#ent", "<e1>", "is", "necessary", "for", "maintenance", "of", "C1366439#ent", "<e2>", "as", "hypophysectomy", "results", "in", "complete", "loss", "of", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [9, 10]}}
{"token": ["Four", "single-nucleotide", "polymorphisms", "been", "found", "in", "the", "human", "C3710678#ent", "<e1>", "which", "encodes", "a", "C0031727#ent", "<e2>", "involved", "in", "the", "mitotic", "spindle", "checkpoint"], "h": {"id": "C3710678", "name": "C3710678#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["Mutations", "of", "C3710678#ent", "<e1>", "or", "BubR1", ",", "genes", "coding", "for", "C0031727#ent", "<e2>", "involved", "in", "mitotic", "spindle", "assembly", "checkpoint", "signaling", "are", "found", "in", "a", "small", "subset", "of", "aneuploid", "tumors", "."], "h": {"id": "C3710678", "name": "C3710678#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}}
{"token": ["Energy", "depletion", "with", "the", "ATP", "synthase", "inhibitor", "oligomycin", "or", "the", "C0007044#ent", "<e1>", "the", "presence", "of", "C0011501#ent", "<e2>", "prevented", "the", "perinuclear", "clustering", "the", "mitochondria", "and", "the", "cell", "killing"], "h": {"id": "C0007044", "name": "C0007044#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011501", "name": "C0011501#ent", "pos": [15, 16]}}
{"token": ["The", "metabolic", "inhibitors", "C0007044#ent", "<e1>", "KCN", "(", "when", "incubated", "simultaneously", "with", "C0011501#ent", "<e2>", ")", "inhibited", "NA-ascorbate", "and", "AIB", "release", "by", "greater", "than", "75", "%", "."], "h": {"id": "C0007044", "name": "C0007044#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011501", "name": "C0011501#ent", "pos": [11, 12]}}
{"token": ["This", "observation", "provides", "new", "insight", "to", "a", "long-standing", "enigma", "that", "the", "major", "predisposing", "factor", "C0024131#ent", "<e1>", "is", "deficiency", "in", "complement", "C1q", "C4283853#ent", "<e2>", "."], "h": {"id": "C0024131", "name": "C0024131#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [21, 22]}}
{"token": ["A(2A", ")", "C4284124#ent", "<e1>", "sensitized", "group", "further", "had", "increased", "C2986464#ent", "<e2>", "expression", "and", "nitrosative", "stress", "with", "WT", "sensitized", "group", "."], "h": {"id": "C4284124", "name": "C4284124#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [9, 10]}}
{"token": ["Moreover", "beta", "1,4", "N-acetylgalactosaminyltransferase", "C4283926#ent", "<e1>", "activity", "increased", "in", "NSC-34", "cells", "cultured", "with", "C1413557#ent", "<e2>", "."], "h": {"id": "C4283926", "name": "C4283926#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413557", "name": "C1413557#ent", "pos": [13, 14]}}
{"token": ["C4283926#ent", "<e1>", "might", "be", "a", "functional", "modulator", "of", "C1413557#ent", "<e2>", "in", "motor", "neurons"], "h": {"id": "C4283926", "name": "C4283926#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413557", "name": "C1413557#ent", "pos": [8, 9]}}
{"token": ["The", "selectivity", "of", "these", "new", "inhibitors", "for", "C0257535#ent", "<e1>", "eight", "other", "C0033640#ent", "<e2>", "high", "and", "in", "all", "cases", "exceeds", "that", "of", "SB", "203580", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [11, 12]}}
{"token": ["The", "C0013227#ent", "<e1>", "in", "rats", "by", "intraperitoneal", "injections", "C0036444#ent", "<e2>", "1.2", "mg/kg", ")", "was", "treated", "as", "a", "putative", "aversive", "US", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036444", "name": "C0036444#ent", "pos": [8, 9]}}
{"token": ["Several", "recently", "determined", "and", "exciting", "structures", "of", "C1420261#ent", "<e1>", ",", "C1417767#ent", "<e2>", ",", "and", "an", "active", "transcription", "complex", "of", "C1420261#ent", "<e1>", ",", "C1417767#ent", "<e2>", "and", "Mastermind", "have", "revealed", "new", "insights", "into", "transcriptional", "regulation", "the", "Notch", "pathway"], "h": {"id": "C1420261", "name": "C1420261#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417767", "name": "C1417767#ent", "pos": [10, 11]}}
{"token": ["The", "C3536711#ent", "<e1>", "activities", "of", "C0164707#ent", "<e2>", "TFPI", ")", ",", "heparin", "and", "hirudin", "were", "compared", "in", "intrinsic", "(", "APTT", ")", "and", "extrinsic", "(", "PT", ")", "activated", "clotting", "assays"], "h": {"id": "C3536711", "name": "C3536711#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0164707", "name": "C0164707#ent", "pos": [5, 6]}}
{"token": ["Carteolol", "treatment", "increased", "beta-adrenergic", "receptor", "density", "and", "the", "high", "C0543450#ent", "<e1>", "dose", "restored", "SR", "Ca2", "+", "-ATPase", "and", "myofibrillar", "C0001473#ent", "<e2>", "activities", ",", "along", "with", "creatine", "kinase", "lactate", "dehydrogenase", "aspartate", "transaminase", "and", "ATP", "synthase", "activities", ",", "to", "normal", "."], "h": {"id": "C0543450", "name": "C0543450#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [19, 20]}}
{"token": ["We", "devised", "a", "method", "to", "selectively", "ablate", "these", "neurons", "in", "neonatal", "mice", "and", "then", "tested", "adult", "mice", "for", "their", "feeding", "responses", "fasting", ",", "C0020616#ent", "<e1>", "2-deoxy-d-glucose", "and", "a", "ghrelin", "receptor", "C2987634#ent", "<e2>", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [30, 31]}}
{"token": ["Treatment", "with", "benidipine", "for", "2", "days", "increased", "the", "level", "of", "C0080058#ent", "<e1>", "partially", "reduced", "C1136240#ent", "<e2>", "p70S6K1", ")", "activity", "."], "h": {"id": "C0080058", "name": "C0080058#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1136240", "name": "C1136240#ent", "pos": [14, 15]}}
{"token": ["Thirty-eight", "percent", "of", "the", "patients", "received", "C0728960#ent", "<e1>", "such", "as", "C0700583#ent", "<e2>", "and", "acetaminophen", "suppositories", "and", "intravenous", "pentazocine"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [10, 11]}}
{"token": ["While", "the", "test", "compounds", "significant", "activity", ",", "the", "compounds", "A1", "A2", ",", "A3", "and", "A4", "shown", "more", "potent", "C0728960#ent", "<e1>", "and", "the", "compound", "A4", "more", "potent", "anti-inflammatory", "activity", "the", "C0700583#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [29, 30]}}
{"token": ["Lec3", "Chinese", "hamster", "ovary", "CHO", ")", "cell", "glycosylation", "mutants", "have", "a", "defect", "in", "sialic", "acid", "biosynthesis", "is", "shown", "here", "to", "be", "reflected", "most", "sensitively", "in", "reduced", "C0071677#ent", "<e1>", "PSA", ")", "on", "C1413393#ent", "<e2>"], "h": {"id": "C0071677", "name": "C0071677#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1413393", "name": "C1413393#ent", "pos": [31, 32]}}
{"token": ["ST8Sia", "II", "STX", ")", "and", "ST8Sia", "IV", "PST", ")", "are", "C0071677#ent", "<e1>", "polySia", ")", "synthases", "that", "catalyze", "polySia", "formation", "of", "C1413393#ent", "<e2>", "NCAM", ")", "in", "vivo", "in", "vitro"], "h": {"id": "C0071677", "name": "C0071677#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413393", "name": "C1413393#ent", "pos": [20, 21]}}
{"token": ["A", "limited", "number", "of", "mammalian", "proteins", "modified", "by", "C0071677#ent", "<e1>", "with", "the", "C1413393#ent", "<e2>", "NCAM", ")", "being", "the", "most", "abundant", "of", "these", "."], "h": {"id": "C0071677", "name": "C0071677#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413393", "name": "C1413393#ent", "pos": [12, 13]}}
{"token": ["C0019562#ent", "<e1>", "is", "confined", "to", "C1417613#ent", "<e2>", "until", "neutral", "pH", "conditions", "are", "reinstated", "."], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [5, 6]}}
{"token": ["The", "content", "of", "selected", "C0031428#ent", "<e1>", "resveratrol", "(", "trans-3,5,4'-trihydroxystilbene", ")", "and", "its", "C0524933#ent", "<e2>", "and", "glucosides", "(", "piceides", ")", "were", "monitored", "in", "grape", "(", "Vitis", "vinifera", "L.", "cv", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0524933", "name": "C0524933#ent", "pos": [12, 13]}}
{"token": ["In", "this", "paper", ",", "we", "characterize", "a", "T-tagged", "C0242988#ent", "<e1>", "knockout", "mutant", "a", "series", "of", "transgenic", "plant", "lines", "which", "over-express", "PHR1", "in", "C1883559#ent", "<e2>", "WT", ")", "and", "C0242988#ent", "<e1>", "mutant", "background", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0242988", "name": "C0242988#ent", "pos": [8, 9]}}
{"token": ["This", "led", "to", "the", "cloning", "of", "a", "C1420874#ent", "<e1>", "expressed", "in", "rabbit", "C3888088#ent", "<e2>", "during", "this", "change", "."], "h": {"id": "C1420874", "name": "C1420874#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [12, 13]}}
{"token": ["The", "C0012315#ent", "<e1>", "channel", "modulators", "(", "-", ")", "Bay", "K", "8644", "R5417", ")", "and", "C0028094#ent", "<e2>", "were", "used", "to", "study", "the", "role", "of", "voltage-gated", "Ca2+", "channels", "the", "regulation", "of", "PRL", "gene", "transcription", "GH3", "cells", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [14, 15]}}
{"token": ["This", "effect", "is", "independent", "of", "its", "L-type", "calcium", "channel", "blocking", "effect", ",", "and", "is", "not", "mimicked", "by", "other", "C0012315#ent", "<e1>", "such", "as", "C0028094#ent", "<e2>", ",", "nicardipine", ",", "or", "Bay", "K", "8644"], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [18, 19]}, "relation": "chemical_structure_of", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [22, 23]}}
{"token": ["Short", "term", "anaesthesia", "induced", "with", "C0043366#ent", "<e1>", "and", "ketamine", "was", "compared", "to", "a", "combination", "of", "C0043366#ent", "<e1>", ",", "ketamine", "and", "C0039468#ent", "<e1>", "(", "a", "benzodiazepine", ")", "in", "six", "adult", "horses", "."], "h": {"id": "C0043366", "name": "C0043366#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039468", "name": "C0039468#ent", "pos": [20, 21]}}
{"token": ["Thyroid", "hormone", "receptors", "function", "by", "binding", "to", "specific", "C1842747#ent", "<e1>", "promoters", "of", "target", "C0017337#ent", "<e2>", "and", "by", "regulating", "transcription"], "h": {"id": "C1842747", "name": "C1842747#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["C3714581#ent", "<e1>", "the", "most", "frequent", "type", "of", "C1691228#ent", "<e2>", "also", "one", "of", "the", "most", "common", "causes", "of", "abdominal", "mass", "childhood", "."], "h": {"id": "C3714581", "name": "C3714581#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C1691228", "name": "C1691228#ent", "pos": [7, 8]}}
{"token": ["One", "soft", "tissue", "chondroma", "had", "a", "t(3;12)(q27;q15", ")", ",", "and", "the", "RT-PCR", "analysis", "an", "C3274727#ent", "<e1>", "transcript", ",", "composed", "of", "C1333906#ent", "<e2>", "exons", "1-3", "LPP", "exons", "9", "-", "11", "."], "h": {"id": "C3274727", "name": "C3274727#ent", "pos": [14, 15]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333906", "name": "C1333906#ent", "pos": [20, 21]}}
{"token": ["The", "primary", "agents", "for", "cartilage", "and", "bone", "destruction", "C0022408#ent", "<e1>", "active", "proteinases", "collagen", "and", "C1418888#ent", "<e2>", "."], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [14, 15]}}
{"token": ["The", "first", "biochemical", "changes", "of", "cartilage", "in", "C0022408#ent", "<e1>", "associate", "a", "disorder", "of", "C1418888#ent", "<e2>", "aggregation", "and", "an", "increase", "in", "the", "water", "content"], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [13, 14]}}
{"token": ["The", "present", "experiments", "investigate", "the", "effects", "of", "phenoxybenzamine", "and", "C0033497#ent", "<e1>", ",", "singly", "and", "in", "combination", ",", "on", "plasma", "C3536742#ent", "<e2>", "levels", "in", "sheep", "receiving", "a", "three-hour", "adrenaline", "infusion", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [19, 20]}}
{"token": ["Bronchial", "relaxations", "to", "histamine", "were", "resistant", "to", "indomethacin", "and", "C0033497#ent", "<e1>", "suggesting", "that", "prostaglandin", "and", "C3536742#ent", "<e2>", "release", "mechanisms", "were", "not", "involved", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [15, 16]}}
{"token": ["None", "of", "the", "180", "Belgian", "C0011854#ent", "<e1>", "patients", "had", "Addison", "'", "s", "disease", "or", "developed", "an", "C0405580#ent", "<e2>", "follow", "up", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [16, 17]}}
{"token": ["The", "CCN3", "protein", "Nov", ",", "Nephroblastoma", "overexpressed", ")", "is", "a", "member", "of", "the", "CCN", "family", "C1413896#ent", "<e1>", ",", "CTGF", ",", "Nov", ")", "of", "growth", "regulators", "exerts", "C0003392#ent", "<e2>"], "h": {"id": "C1413896", "name": "C1413896#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [26, 27]}}
{"token": ["Pull-down", "assays", "using", "glutathione", "S-transferase", "C3816729#ent", "<e1>", "that", "RFP", "is", "associated", "with", "C0812305#ent", "<e2>", ",", "EPcB", ",", "and", "carboxy-terminal", "(", "CT", ")", "regions", "of", "EPC1", "."], "h": {"id": "C3816729", "name": "C3816729#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812305", "name": "C0812305#ent", "pos": [12, 13]}}
{"token": ["C0270612#ent", "<e1>", "WSD", ")", "is", "a", "C0277550#ent", "<e2>", "by", "a", "virus", "commonly", "known", "as", "white", "spot", "syndrome", "virus", "WSSV", ")", "."], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0277550", "name": "C0277550#ent", "pos": [6, 7]}}
{"token": ["Until", "now", "11", "adult", "patients", "and", "2", "children", "with", "C0017205#ent", "<e1>", "diagnosed", "in", "Croatia", "and", "all", "are", "on", "enzyme", "replacement", "therapy", "C0291140#ent", "<e2>", "."], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0291140", "name": "C0291140#ent", "pos": [21, 22]}}
{"token": ["Miglustat", "is", "now", "licensed", "for", "oral", "therapy", "patients", "with", "mild", "to", "moderate", "type", "1", "C0017205#ent", "<e1>", "who", "can", "not", "take", "C0291140#ent", "<e2>", ",", "regardless", "of", "the", "reason", "."], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0291140", "name": "C0291140#ent", "pos": [20, 21]}}
{"token": ["To", "evaluate", "the", "feasibility", "of", "financing", "the", "treatment", "of", "C0017205#ent", "<e1>", "recombinant", "human", "C0291140#ent", "<e2>", "in", "the", "Croatian", "health", "care", "system", "."], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0291140", "name": "C0291140#ent", "pos": [13, 14]}}
{"token": ["We", "also", "identified", "that", "GSTM1", "null", "genotype", "a", "candidate", "C0079429#ent", "<e1>", "for", "susceptibility", "to", "C0085077#ent", "<e2>", "and", "was", "associated", "with", "autoantibody", "production", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085077", "name": "C0085077#ent", "pos": [14, 15]}}
{"token": ["These", "2", "cases", "had", "been", "affected", "by", "C0013295#ent", "<e1>", "non", "responding", "to", "H2", "antagonists", "nocturnal", "doses", "60", "and", "80", "mg", "C0015620#ent", "<e2>", "till", "the", "secretory", "values", "decreased", "below", "the", "ulcerogenic", "limit", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0015620", "name": "C0015620#ent", "pos": [20, 21]}}
{"token": ["Limb-girdle", "muscular", "dystrophy", "LGMD", ")", "has", "been", "linked", "to", "15", "chromosomal", "loci", "7", "autosomal-dominant", "(", "C1834659#ent", "<e1>", "to", "E", ")", "and", "10", "autosomal-recessive", "(", "C1846672#ent", "<e2>", "to", "J", ")", "."], "h": {"id": "C1834659", "name": "C1834659#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1846672", "name": "C1846672#ent", "pos": [24, 25]}}
{"token": ["We", "tested", "the", "effects", "of", "tissue", "plasminogen", "activator", "C0032143#ent", "<e1>", ")", "with", "the", "glutamate", "antagonist", "MK-801", "or", "the", "calcium", "channel", "blocker", "C0028094#ent", "<e2>", "in", "an", "embolic", "stroke", "model", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [21, 22]}}
{"token": ["We", "tested", "the", "effects", "of", "C0032143#ent", "<e1>", "t-PA", ")", "with", "the", "glutamate", "antagonist", "MK-801", "or", "the", "calcium", "channel", "blocker", "C0028094#ent", "<e2>", "in", "an", "embolic", "stroke", "model", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [19, 20]}}
{"token": ["Although", "C0031441#ent", "<e1>", "itself", "induced", "antinociception", "it", "did", "not", "alter", "the", "C0004609#ent", "<e2>", "response", "significantly", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004609", "name": "C0004609#ent", "pos": [11, 12]}}
{"token": ["The", "catalytic", "site", "which", "is", "open", "to", "the", "solvent", "in", "the", "unactivated", "C0027203#ent", "<e1>", ",", "becomes", "shielded", "in", "the", "activated", "C1419788#ent", "<e2>", "complex", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419788", "name": "C1419788#ent", "pos": [20, 21]}}
{"token": ["Traditional", "slower", "acting", "C0003191#ent", "<e1>", "such", "as", "gold", "therapy", "penicillamine", ",", "sulfasalazine", ",", "tiopronin", "and", "C0596007#ent", "<e2>", ",", "are", "usually", "poorly", "active", "in", "children", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0596007", "name": "C0596007#ent", "pos": [15, 16]}}
{"token": ["Older", "disease", "C0003191#ent", "<e1>", "DMARDs", ")", "include", "methotrexate", ",", "sulphasalazine", "and", "C0596007#ent", "<e2>", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0596007", "name": "C0596007#ent", "pos": [11, 12]}}
{"token": ["The", "decrease", "of", "C0669372#ent", "<e1>", "mRNA", "by", "C0005640#ent", "<e2>", "was", "abolished", "by", "sepiapterin", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005640", "name": "C0005640#ent", "pos": [7, 8]}}
{"token": ["Food", "fortification", "minerals", "and", "vitamins", "helps", "eliminate", "diseases", "such", "as", "goiter", ",", "C0035579#ent", "<e1>", ",", "beriberi", ",", "and", "C0030783#ent", "<e2>", "."], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030783", "name": "C0030783#ent", "pos": [18, 19]}}
{"token": ["Our", "findings", "indicate", "that", "C3812805#ent", "<e1>", "is", "involved", "in", "the", "MAPK", "cascade", "NF-kappaB", "pathway", "is", "activated", "by", "C2827557#ent", "<e2>", "."], "h": {"id": "C3812805", "name": "C3812805#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2827557", "name": "C2827557#ent", "pos": [17, 18]}}
{"token": ["Dominant", "negative", "forms", "of", "C3812805#ent", "<e1>", "and", "TAB2", "inhibit", "NF-kappaB", "activation", "induced", "by", "overexpression", "of", "C2827557#ent", "<e2>", "."], "h": {"id": "C3812805", "name": "C3812805#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2827557", "name": "C2827557#ent", "pos": [15, 16]}}
{"token": ["Interestingly", ",", "the", "gold(I", ")", "compound", "C0018034#ent", "<e1>", "was", "poorly", "effective", ",", "both", "in", "inhibiting", "C0039941#ent", "<e2>", "in", "inducing", "apoptosis", "."], "h": {"id": "C0018034", "name": "C0018034#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039941", "name": "C0039941#ent", "pos": [15, 16]}}
{"token": ["While", "the", "DNA", "damage-inducible", "Nbs1", "foci", "formation", "is", "normal", "in", "WS", "cells", ",", "C1337007#ent", "<e1>", "focus", "formation", "is", "defective", "in", "C0398791#ent", "<e2>"], "h": {"id": "C1337007", "name": "C1337007#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0398791", "name": "C0398791#ent", "pos": [20, 21]}}
{"token": ["The", "WRN", "protein", "is", "mutated", "in", "the", "chromosomally", "unstable", "C1337007#ent", "<e1>", "WS", ")", "and", "the", "Nbs1", "protein", "mutated", "in", "Nijmegen", "breakage", "syndrome", "C0398791#ent", "<e2>", ")", "."], "h": {"id": "C1337007", "name": "C1337007#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0398791", "name": "C0398791#ent", "pos": [22, 23]}}
{"token": ["The", "WRN", "protein", "is", "mutated", "in", "the", "chromosomally", "unstable", "C1337007#ent", "<e1>", "WS", ")", "and", "the", "Nbs1", "protein", "mutated", "in", "C0398791#ent", "<e2>", "NBS", ")", "."], "h": {"id": "C1337007", "name": "C1337007#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0398791", "name": "C0398791#ent", "pos": [19, 20]}}
{"token": ["Constitutive", "GH", "release", "from", "GH3", "cells", "was", "greatly", "diminished", "in", "the", "presence", "of", "inhibitors", "for", "C1514550#ent", "<e1>", "while", "stimulative", "GH", "release", "by", "C1417809#ent", "<e2>", "was", "not", "affected", "."], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417809", "name": "C1417809#ent", "pos": [22, 23]}}
{"token": ["Quantization", "of", "immunostained", "tissue", "sections", "image", "analysis", "technique", "that", "vinblastine/", "C0042679#ent", "<e1>", "induced", "overexpression", "of", "P-gp", "was", "effectively", "reversed", "by", "C0063491#ent", "<e2>", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0063491", "name": "C0063491#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "case", "of", "C0270786#ent", "<e1>", "with", "tremor", "and", "C0016399#ent", "<e2>", "few", "days", "after", "introduction", "of", "cyclosporin", "A", "Cy", "A", "in", "a", "kidney", "recipient"], "h": {"id": "C0270786", "name": "C0270786#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016399", "name": "C0016399#ent", "pos": [10, 11]}}
{"token": ["As", "tubulointerstitial", "damage", "regarded", "secondary", "to", "glomerular", "injury", "C4054155#ent", "<e1>", "we", "assessed", "lesions", "to", "renal", "tubulointerstitium", "recently", "diagnosed", "C0268731#ent", "<e2>", "evaluated", "their", "impact", "on", "progression", "of", "the", "disease", "during", "the", "first", "2", "years", "after", "diagnosis", "."], "h": {"id": "C4054155", "name": "C4054155#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [18, 19]}}
{"token": ["Effects", "of", "C0242898#ent", "<e1>", "GABA", ")", "and", "gamma-amino-beta-hydroxybutyric", "acid", "C0048005#ent", "<e2>", ")", "on", "growth", "hormone", "GH", ")", "release", "were", "investigated", "in", "the", "urethaneanesthetized", "male", "rat", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0048005", "name": "C0048005#ent", "pos": [9, 10]}}
{"token": ["The", "enzyme", "was", "completely", "devoid", "of", "any", "spontaneous", "activity", "could", "be", "activated", "by", "a", "C0812312#ent", "<e1>", "FA", ")", "in", "the", "presence", "of", "C2744579#ent", "<e2>", "and", "Mg", "ions", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [22, 23]}}
{"token": ["The", "C0812312#ent", "<e1>", "tyrosine", "5-monooxygenase", "well", "as", "tryptophan", "5-monooxygenase", "the", "presence", "of", "C2744579#ent", "<e2>", ",", "Mg2", "+", ",", "Ca2", "+", ",", "calmodulin", ",", "and", "Ca2", "+", "-", ",", "calmodulin-dependent", "protein", "kinase"], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [12, 13]}}
{"token": ["At", "8", "months", ",", "untreated", "C0026708#ent", "<e1>", "mice", "had", "C0003504#ent", "<e2>", "increased", "bone", "mineral", "density", "BMD", ")", ",", "and", "reduced", "responses", "to", "sound", "and", "light", "."], "h": {"id": "C0026708", "name": "C0026708#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [9, 10]}}
{"token": ["In", "vitro", "experiments", "and", "animal", "studies", "that", "C2984537#ent", "<e1>", "discloses", "anti-inflammatory", "property", "PPARgamma", "discloses", "anti-inflammatory", ",", "antifibrogenic", "and", "C0003392#ent", "<e2>", "the", "liver", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [18, 19]}}
{"token": ["We", "found", "that", "the", "expression", "of", "C3538973#ent", "<e1>", "AID", ")", ",", "a", "C0010723#ent", "<e2>", "correlated", "with", "mutation", "rates", "in", "Ramos", "subclones", "."], "h": {"id": "C3538973", "name": "C3538973#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010723", "name": "C0010723#ent", "pos": [12, 13]}}
{"token": ["Seventy-four", "patients", "were", "enrolled", "in", "this", "double-blind", ",", "randomized", "single-center", "study", "evaluate", "the", "therapeutic", "effectiveness", "50", "mg", "tid", "regimens", "of", "C0016377#ent", "<e1>", "or", "diclofenac", "sodium", "patients", "with", "C0029408#ent", "<e2>", "of", "the", "knee", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [27, 28]}}
{"token": ["A", "double-blind", "cross-over", "study", "undertaken", "comparing", "the", "analgesic", "nefopam", "with", "the", "NSAID", "C0016377#ent", "<e1>", "in", "the", "treatment", "of", "C0029408#ent", "<e2>", "of", "the", "knees", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [18, 19]}}
{"token": ["A", "comparative", "study", "conducted", "to", "evaluate", "the", "therapeutic", "efficacy", "of", "diclofenac", "sodium", "C0016377#ent", "<e1>", "both", "non-steroidal", "anti-inflammatory", "drugs", "NSAIDS", ")", "in", "C0029408#ent", "<e2>", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [21, 22]}}
{"token": ["The", "ET-", "and", "phenylephrine-induced", "contractions", "in", "Ca2(+)-free", "C0036421#ent", "<e1>", "were", "inhibited", "by", "H-7", ",", "a", "C1415545#ent", "<e2>"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415545", "name": "C1415545#ent", "pos": [15, 16]}}
{"token": ["C0013502#ent", "<e1>", "is", "a", "common", "C0043528#ent", "<e2>", "that", "affects", "a", "large", "number", "of", "humans", "and", "animals", ",", "especially", "in", "poorly", "developed", "countries", "."], "h": {"id": "C0013502", "name": "C0013502#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [5, 6]}}
{"token": ["C0012610#ent", "<e1>", ",", "lipase", ",", "amylase", ",", "C2004317#ent", "<e2>", "and", "phosphatases", ",", "were", "also", "affected", "by", "dietary", "HCH", "and", "gamma-HCH", "."], "h": {"id": "C0012610", "name": "C0012610#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2004317", "name": "C2004317#ent", "pos": [7, 8]}}
{"token": ["The", "C0304513#ent", "<e1>", "yohimbine", "or", "C0063327#ent", "<e2>", "but", "not", "the", "alpha", "1-adrenoreceptor", "antagonist", "prazosin", ",", "given", "intravenously", ",", "reduced", "the", "inhibitory", "effect", "of", "B-HT", "920", "on", "positive", "chronotropic", "responses", "to", "cardiac", "sympathetic", "nerve", "stimulation", "."], "h": {"id": "C0304513", "name": "C0304513#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0063327", "name": "C0063327#ent", "pos": [5, 6]}}
{"token": ["The", "Schild", "regression", "C0063327#ent", "<e1>", "and", "pharmacologic", "resultant", "analysis", "suggested", "that", "the", "rat", "anococcygeus", "muscle", "responds", "to", "C0304513#ent", "<e2>", "alpha-1-mediated", "contractions", "and", "C0063327#ent", "<e1>", "competes", "with", "alpha-1", "antagonists", "the", "same", "site", ",", "i.e.", ",", "alpha-1", "adrenoceptor", "site"], "h": {"id": "C0304513", "name": "C0304513#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0063327", "name": "C0063327#ent", "pos": [3, 4]}}
{"token": ["She", "died", "of", "C0264490#ent", "<e1>", "years", "after", "the", "development", "of", "C0231807#ent", "<e2>", "and", "autopsy", "revealed", "LAM", "."], "h": {"id": "C0264490", "name": "C0264490#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0231807", "name": "C0231807#ent", "pos": [10, 11]}}
{"token": ["A", "plasmid", "was", "designed", "to", "encode", "a", "beta-galactosidase", "reporter", "gene", "the", "control", "of", "capR", ",", "an", "C1422492#ent", "<e1>", "involved", "in", "C0031428#ent", "<e2>", "degradation", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [20, 21]}}
{"token": ["Results", "demonstrated", "that", "C0064980#ent", "<e1>", "and", "butylidenephthalide", "can", "act", "on", "rat", "artery", "cell", "membrane", "to", "C0280858#ent", "<e2>", "in", "CMC", "system", "."], "h": {"id": "C0064980", "name": "C0064980#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [15, 16]}}
{"token": ["However", ",", "this", "approach", "has", "a", "major", "limitation", ":", "1:1", "stoichiometry", "of", "the", "C0027203#ent", "<e1>", "detoxification", "of", "those", "C3653404#ent", "<e2>", "no", "carboxyl", "ester", "bonds", ",", "such", "as", "paraoxon", ",", "chlorpyrifos", "etc", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3653404", "name": "C3653404#ent", "pos": [18, 19]}}
{"token": ["The", "C0248868#ent", "<e1>", "CaMKII", ")", "and", "the", "C0031678#ent", "<e2>", "CaN", ")", "are", "Ca(2+)/calmodulin-binding", "proteins", "that", "are", "very", "abundant", "in", "the", "central", "nervous", "system"], "h": {"id": "C0248868", "name": "C0248868#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031678", "name": "C0031678#ent", "pos": [7, 8]}}
{"token": ["Mortality", "in", "nonresponding", "pneumonia", "increases", "3-fold", "in", "C0206171#ent", "<e1>", "and", "5-fold", "in", "C0949083#ent", "<e2>", "compared", "with", "global", "mortality", "hospitalized", "patients", "."], "h": {"id": "C0206171", "name": "C0206171#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0949083", "name": "C0949083#ent", "pos": [12, 13]}}
{"token": ["C0206171#ent", "<e1>", "nursing", "home-acquired", "pneumonia", "and", "C0949083#ent", "<e2>", "the", "elderly", "are", "reviewed", "from", "a", "diagnostic", "and", "therapeutic", "perspective", "."], "h": {"id": "C0206171", "name": "C0206171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0949083", "name": "C0949083#ent", "pos": [6, 7]}}
{"token": ["C1840333#ent", "<e1>", "also", "known", "as", "C0020626#ent", "<e2>", ",", "sensorineural", "deafness", "and", "renal", "dysplasia", "syndrome", "an", "extremely", "rare", "congenital", "disorder"], "h": {"id": "C1840333", "name": "C1840333#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020626", "name": "C0020626#ent", "pos": [5, 6]}}
{"token": ["C1418251#ent", "<e1>", "can", "be", "associated", "with", "multiple", "conditions", "risk", "factors", "eg", ",", "collagen", "vascular", "diseases", "liver", "disease", "C3854222#ent", "<e2>", "congenital", "heart", "disease", "or", "ingestion", "of", "certain", "medications", "or", "toxins", ")", "or", "it", "can", "be", "idiopathic", "."], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [17, 18]}}
{"token": ["If", "THP-1", "cells", "were", "pretreated", "before", "C0042769#ent", "<e1>", "TPA", "and", "became", "differentiated", "at", "the", "time", "of", "C0010823#ent", "<e2>", "MIE", "gene", "expression", "increased", "by", "5", "-", "6", "fold", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [16, 17]}}
{"token": ["Also", ",", "some", "C0042769#ent", "<e1>", "in", "immune", "depressed", "patients", "such", "as", "C0010823#ent", "<e2>", "recommended", "to", "be", "treated", "with", "intravenous", "immunoglobulin", "IVIg", ")", "in", "combination", "with", "antiviral", "therapy"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [11, 12]}}
{"token": ["In", "mammals", ",", "C1416523#ent", "<e1>", "IVD", ")", ",", "an", "C0014442#ent", "<e2>", "of", "the", "leucine", "catabolic", "pathway", "is", "a", "mitochondrial", "protein", "as", "other", "acyl-CoA", "dehydrogenases", "in", "fatty", "acid", "beta-oxidation"], "h": {"id": "C1416523", "name": "C1416523#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["We", "have", "isolated", "a", "mouse", "homolog", "of", "the", "C1823656#ent", "<e1>", "termed", "mouse", "C3889712#ent", "<e2>", "(", "mWAPL", ")", ",", "as", "a", "target", "of", "TCDD", "by", "cDNA", "representational", "difference", "analysis", "from", "mouse", "embryonic", "stem", "cells"], "h": {"id": "C1823656", "name": "C1823656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3889712", "name": "C3889712#ent", "pos": [12, 13]}}
{"token": ["In", "six", "C0027121#ent", "<e1>", "localized", "in", "the", "vicinity", "of", "C0037284#ent", "<e2>", "arthritis", "or", "neuropathy", "caused", "by", "Borrelia", "burgdorferi"], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [9, 10]}}
{"token": ["Compounds", "analysed", "include", "acetaldehyde", ",", "C0000997#ent", "<e1>", ",", "acetoine", "(", "3-hydroxy", "butanone", ")", ",", "C0001975#ent", "<e2>", "their", "acetates", ",", "and", "fatty", "acids", "their", "ethyl", "esters"], "h": {"id": "C0000997", "name": "C0000997#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [14, 15]}}
{"token": ["In", "this", "report", ",", "it", "is", "demonstrated", "that", "the", "minimal", "domain", "for", "the", "polymerizing", "activity", "the", "C0083910#ent", "<e1>", "smaller", "than", "the", "C1335439#ent", "<e2>"], "h": {"id": "C0083910", "name": "C0083910#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [21, 22]}}
{"token": ["In", "a", "three-month", ",", "double-masked", ",", "randomized", "clinical", "trial", "we", "evaluated", "the", "once-daily", "ocular", "hypotensive", "efficacy", "of", "0.25", "%", "C0006388#ent", "<e1>", "and", "0.25", "%", "timolol", "in", "80", "patients", "with", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0006388", "name": "C0006388#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [29, 30]}}
{"token": ["The", "rapid", "enhancement", "of", "membrane", "ruffling", "pinocytosis", "is", "induced", "by", "both", "the", "C0033713#ent", "<e1>", "and", "the", "oncogenic", "forms", "of", "the", "C0079972#ent", "<e2>"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079972", "name": "C0079972#ent", "pos": [20, 21]}}
{"token": ["Nine", "chromosomal", "loci", "for", "this", "condition", "have", "been", "identified", ":", "C3815884#ent", "<e1>", "essential", "and", "regulatory", "myosin", "light", "chains", "troponin", "T", "I", "subunits", "C3811246#ent", "<e2>", ",", "cardiac", "myosin", "binding", "protein", "C", "cardiac", "actin", "titin", "."], "h": {"id": "C3815884", "name": "C3815884#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3811246", "name": "C3811246#ent", "pos": [22, 23]}}
{"token": ["Known", "mutations", "imply", "structural", "and", "functional", "changes", "in", "the", "following", "proteins", ":", "in", "ventricle", "specific", "C3815884#ent", "<e1>", "in", "essential", "and", "regulatory", "myosin", "light", "chains", "in", "troponin", "subunits", "T", "I", ",", "in", "C3811246#ent", "<e2>", "and", "in", "myosin", "binding", "protein-C."], "h": {"id": "C3815884", "name": "C3815884#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3811246", "name": "C3811246#ent", "pos": [31, 32]}}
{"token": ["Although", "very", "infrequent", ",", "lymphadenopathy", "is", "most", "common", "with", "C0031507#ent", "<e1>", ",", "and", "lupus-like", "illnesses", "with", "C0015043#ent", "<e2>", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "LEV", "was", "compared", "with", "reference", "anti-epileptic", "drugs", "(", "AEDs", ")", ":", "carbamazepine", ",", "C0031507#ent", "<e1>", ",", "valproate", ",", "clonazepam", ",", "phenobarbital", "and", "C0015043#ent", "<e2>", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [25, 26]}}
{"token": ["The", "six", "C0026946#ent", "<e1>", "described", "in", "this", "study", "are", "histoplasmosis", ",", "coccidioidomycosis", ",", "C0030409#ent", "<e2>", ",", "blastomycosis", ",", "sporotrichosis", ",", "and", "penicilliosis", "due", "to", "Penicillium", "marneffei"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0030409", "name": "C0030409#ent", "pos": [13, 14]}}
{"token": ["C0291059#ent", "<e1>", "is", "an", "enzyme", "that", "specifically", "degrades", "C1418948#ent", "<e2>", "without", "affecting", "the", "NCAM", "polypeptide", "."], "h": {"id": "C0291059", "name": "C0291059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418948", "name": "C1418948#ent", "pos": [8, 9]}}
{"token": ["We", "have", "generated", "an", "antiserum", "against", "C0032027#ent", "<e1>", "expressed", "as", "a", "bacterial", "fusion", "protein", "this", "antiserum", "detects", "C0032027#ent", "<e1>", "in", "the", "conditioned", "media", "placental", "tissue", "as", "a", "heterogeneous", "population", "C0072522#ent", "<e1>", "."], "h": {"id": "C0032027", "name": "C0032027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [29, 30]}}
{"token": ["C0667292#ent", "<e1>", "a", "molecular", "mass", "137", "kDa", "and", "was", "composed", "of", "two", "C0599220#ent", "<e2>", "103", "kDa", ")", "and", "C", "(", "37", "kDa", ")", "in", "a", "1:1", "molar", "ratio"], "h": {"id": "C0667292", "name": "C0667292#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}}
{"token": ["The", "trophic", "effect", "C0064156#ent", "<e1>", "was", "not", "inhibited", "by", "the", "addition", "of", "C0006945#ent", "<e2>", "."], "h": {"id": "C0064156", "name": "C0064156#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [12, 13]}}
{"token": ["In", "individual", "acinar", "cells", "C0064156#ent", "<e1>", "and", "pilocarpine", "like", "low", "concentrations", "of", "CCK-8", "and", "C0006945#ent", "<e2>", "caused", "oscillations", "of", "[Ca2+]i", "."], "h": {"id": "C0064156", "name": "C0064156#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [14, 15]}}
{"token": ["They", "are", "isolated", "from", "urinary", "tract", "infections", "intra-abdominal", "and", "C0030790#ent", "<e1>", "bacteremias", ",", "wound", "and", "tissue", "infections", "and", "C0014122#ent", "<e2>", "--", "often", "as", "part", "of", "a", "polymicrobial", "flora", "."], "h": {"id": "C0030790", "name": "C0030790#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [18, 19]}}
{"token": ["The", "most", "common", "C1456654#ent", "<e1>", "which", "minic", "idiopathic", "Parkinson's", "disease", "collectively", "called", "C0242422#ent", "<e2>"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [12, 13]}}
{"token": ["The", "1.9", "kb", "5'-flanking", "region", "the", "MK", "gene", "can", "mediate", "C0035339#ent", "<e1>", "acid-responsive", "gene", "expression", "in", "C1366464#ent", "<e2>", "and", "HM-1", "EC", "cells", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366464", "name": "C1366464#ent", "pos": [16, 17]}}
{"token": ["IGF-binding", "protein-3", "C0123707#ent", "<e1>", ")", "is", "a", "multifunctional", "protein", "regulates", "the", "potent", "C0026249#ent", "<e2>", "and", "antiapoptotic", "effects", "of", "IGF-I", "and", "IGF-II", "and", "exerts", "bioactivity", "independent", "of", "modulating", "IGF", "receptor", "activation", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [12, 13]}}
{"token": ["Posttranslational", "linkage", "of", "a", "C0599532#ent", "<e1>", "to", "the", "C0034342#ent", "<e2>", "of", "an", "amino", "acid", "residue", "unprecedented", "in", "ribosomally", "synthesized", "peptides", "or", "proteins", ",", "and", "very", "rare", "in", "secondary", "metabolites"], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [8, 9]}}
{"token": ["Instrumental", "in", "these", "studies", "were", "the", "peptides", "L-alanyl-L-2-thiophenylglycine", "(", "Ala-alpha-TPG", ")", "and", "L-alanyl-L-2-thiophenylglycyl-L-alanine", "(", "Ala-alpha-TPG-Ala", ")", ",", "which", "contain", "C0599532#ent", "<e1>", "attached", "to", "the", "C0034342#ent", "<e2>", "of", "glycine", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [24, 25]}}
{"token": ["Such", "posttranslational", "linkage", "of", "a", "C0599532#ent", "<e1>", "to", "the", "C0034342#ent", "<e2>", "of", "an", "amino", "acid", "residue", "very", "unusual", "in", "natural", "peptides", "proteins", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [9, 10]}}
{"token": ["Th0", "to", "Th1", "deviation", "induced", "by", "C0030956#ent", "<e1>", "86V-->A", "correlated", "with", "up-regulation", "of", "Fyn", "and", "C0246976#ent", "<e2>", "activities", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0246976", "name": "C0246976#ent", "pos": [15, 16]}}
{"token": ["Our", "results", "reveal", "a", "new", "regulatory", "role", "C1413702#ent", "<e1>", "in", "DS", "pathology", "through", "the", "proteasomal", "degradation", "C1414160#ent", "<e2>", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414160", "name": "C1414160#ent", "pos": [16, 17]}}
{"token": ["In", "order", "to", "evaluate", "the", "effects", "of", "C0035078#ent", "<e1>", "RI", ")", "on", "the", "labyrinthine", "absorptive-secretory", "areas", "(", "C0004057#ent", "<e2>", ")", ",", "54", "adult", "Mongolian", "gerbils", "submitted", "to", "bilateral", "nephrectomy", "to", "sham", "procedure"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [17, 18]}}
{"token": ["C0037036#ent", "<e1>", "of", "ANF", "with", "C0020457#ent", "<e2>", "hyperglycaemic", "hypervolaemia", "and", "hyperfiltration", "already", "at", "the", "onset", "of", "DN", ",", "2", "."], "h": {"id": "C0037036", "name": "C0037036#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020457", "name": "C0020457#ent", "pos": [5, 6]}}
{"token": ["Lnk", "blocks", "3", "major", "signaling", "pathways", "Stat5", ",", "C0812228#ent", "<e1>", ",", "and", "MAPK", ",", "induced", "by", "C1414438#ent", "<e2>", "in", "primary", "erythroblasts"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [16, 17]}}
{"token": ["To", "investigate", "a", "possible", "mechanism", "of", "Epo", "'s", "action", "on", "apoptosis", ",", "phosphorylation", "of", "C0812228#ent", "<e1>", "was", "examined", "by", "applying", "C1414438#ent", "<e2>", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [20, 21]}}
{"token": ["C1418245#ent", "<e1>", "deficiency", "is", "associated", "with", "deregulation", "of", "the", "Rho-family", "GTPases", "C0082645#ent", "<e2>", ",", "Rac1", "and", "RhoA", ",", "and", "ensuing", "actin", "cytoskeletal", "defects", "but", "the", "link", "between", "C1418245#ent", "<e1>", "and", "Rho", "GTPases", "unclear", "."], "h": {"id": "C1418245", "name": "C1418245#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [11, 12]}}
{"token": ["Small", "amounts", "C0010648#ent", "<e1>", "and", "EDTA", "in", "the", "buffers", "further", "stabilized", "the", "C3540772#ent", "<e2>", ",", "but", "stripped", "some", "of", "the", "metal", "from", "the", "column", "which", ",", "nonetheless", ",", "retained", "good", "chromatographic", "characteristics", "."], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [12, 13]}}
{"token": ["C0025048#ent", "<e1>", "a", "13-residue", "amidated", "peptide", "that", "activates", "C3811152#ent", "<e2>", "synthesis", "in", "adult", ",", "but", "not", "larval", ",", "lepidopteran", "CA", "."], "h": {"id": "C0025048", "name": "C0025048#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3811152", "name": "C3811152#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "C3273406#ent", "<e1>", "not", "be", "associated", "with", "development", "of", "C0677607#ent", "<e2>", "NOD", "mice", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [12, 13]}}
{"token": ["The", "results", "support", "our", "hypothesis", "that", "presentation", "of", "self-antigen", "may", "be", "a", "result", "of", "insufficient", "C3273406#ent", "<e1>", "in", "the", "thyrocytes", "in", "C0677607#ent", "<e2>"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [21, 22]}}
{"token": ["Our", "results", "suggest", "that", "doxantrazole", "or", "related", "C0282555#ent", "<e1>", "be", "useful", "in", "the", "treatment", "of", "C0042109#ent", "<e2>"], "h": {"id": "C0282555", "name": "C0282555#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [15, 16]}}
{"token": ["The", "C1706027#ent", "<e1>", "to", "11p15", "in", "the", "region", "of", "the", "C0004903#ent", "<e2>"], "h": {"id": "C1706027", "name": "C1706027#ent", "pos": [1, 2]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004903", "name": "C0004903#ent", "pos": [10, 11]}}
{"token": ["C0538269#ent", "<e1>", "requires", "cleavage", "of", "an", "N-terminal", "propeptide", "activation", ",", "and", "C0812295#ent", "<e2>", ",", "a", "metalloprotease", "of", "Listeria", ",", "is", "involved", "in", "the", "proteolytic", "activation", "C0538269#ent", "<e1>", "."], "h": {"id": "C0538269", "name": "C0538269#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812295", "name": "C0812295#ent", "pos": [11, 12]}}
{"token": ["C1839615#ent", "<e1>", "usually", "with", "slowly", "progressing", "C0037771#ent", "<e2>", "accompanied", "by", "loss", "of", "vibratory", "and", "position", "sense", "and", "urinary", "frequency", "urgency", "."], "h": {"id": "C1839615", "name": "C1839615#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037771", "name": "C0037771#ent", "pos": [6, 7]}}
{"token": ["We", "found", "that", "Tyr31/118-phosphorylated", "paxillin", "competes", "with", "C3273319#ent", "<e1>", "for", "binding", "to", "C1419277#ent", "<e2>", ",", "and", "provides", "evidence", "that", "C3273319#ent", "<e1>", "freed", "from", "C1419277#ent", "<e2>", "efficiently", "suppresses", "RhoA", "activity", "during", "cell", "adhesion"], "h": {"id": "C3273319", "name": "C3273319#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419277", "name": "C1419277#ent", "pos": [12, 13]}}
{"token": ["Phosphorylation", "by", "Arg", "also", "promotes", "C3273319#ent", "<e1>", "association", "with", "C1419277#ent", "<e2>", "and", "stimulates", "C3273319#ent", "<e1>", "to", "induce", "neuritogenesis", "in", "neuroblastoma", "cells"], "h": {"id": "C3273319", "name": "C3273319#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419277", "name": "C1419277#ent", "pos": [9, 10]}}
{"token": ["Homozygous", "recessive", "mutations", "in", "the", "C1706041#ent", "<e1>", "C/EBPepsilon", ")", "gene", "were", "described", "in", "two", "of", "five", "C0398593#ent", "<e2>", "patients", ",", "indicating", "loss", "of", "C/EBPepsilon", "function", "the", "primary", "genetic", "defect", "in", "this", "disease", "."], "h": {"id": "C1706041", "name": "C1706041#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0398593", "name": "C0398593#ent", "pos": [16, 17]}}
{"token": ["The", "differences", "in", "pathologic", "findings", "of", "fatal", "cases", "of", "West", "Nile", "virus", "WNV", ")", "C0014060#ent", "<e1>", "in", "the", "context", "of", "underlying", "conditions", "and", "illness", "C0720099#ent", "<e2>", "are", "not", "well", "known", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [24, 25]}}
{"token": ["A", "woman", "with", "C0014060#ent", "<e1>", "of", "six", "years", "C0720099#ent", "<e2>", "developed", "severe", "anaemia", "which", "was", "characterized", "by", "severe", "bone", "marrow", "erythroid", "hypoplasia", "no", "deficiencies", "be", "found", "to", "explain", "this", "finding", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [8, 9]}}
{"token": ["The", "crystal", "structure", "the", "human", "C1705523#ent", "<e1>", "domain", "bound", "to", "the", "C1533646#ent", "<e2>", "Cdk2", ")", "complex", "has", "been", "determined", "at", "2.3", "angstrom", "."], "h": {"id": "C1705523", "name": "C1705523#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1533646", "name": "C1533646#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "DHEA", "increased", "the", "ovarian", "protein", "expressions", "of", "inducible", "NOS", "(", "C0669372#ent", "<e1>", ")", ",", "inducible", "cyclooxygenase", "COX2", ")", "and", "the", "C1514549#ent", "<e2>", "AMPK-alpha", ")", "(", "Thr172", ")", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1514549", "name": "C1514549#ent", "pos": [22, 23]}}
{"token": ["Development", "of", "gene", "therapy", "transfer", "of", "the", "C1412841#ent", "<e1>", "hematopoietic", "progenitors", "represent", "an", "alternative", "strategy", "for", "the", "treatment", "of", "C0311337#ent", "<e2>", "with", "the", "advantage", "of", "a", "definitive", "cure", "for", "XLA", "patients", "."], "h": {"id": "C1412841", "name": "C1412841#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0311337", "name": "C0311337#ent", "pos": [19, 20]}}
{"token": ["C0019880#ent", "<e1>", "was", "proved", "to", "exert", "a", "dual", "effect", "activating", "C0172537#ent", "<e2>", "at", "low", "molar", "ratio", "MR", "10:1", ")", "and", "inhibiting", "active", "MMP2", "at", "high", "molar", "ratio", "MR", ">", "1000:1", ")", "."], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [10, 11]}}
{"token": ["Among", "the", "NTec2-bound", "C1442804#ent", "<e1>", "only", "the", "C1824618#ent", "<e2>", "form", "seems", "to", "be", "inducibly", "tyrosine-phosphorylated", "in", "response", "to", "IL-3", "."], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1824618", "name": "C1824618#ent", "pos": [7, 8]}}
{"token": ["A", "glucocorticoid", "response", "element", "the", "C1420590#ent", "<e1>", "demonstrated", "to", "mediate", "effects", "of", "C3536949#ent", "<e2>", "when", "located", "upstream", "of", "a", "heterologous", "promoter", "linked", "to", "the", "chloramphenicol", "acetyl", "transferase", "gene", "CAT", ")", "."], "h": {"id": "C1420590", "name": "C1420590#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [12, 13]}}
{"token": ["In", "studies", "comparing", "the", "effect", "of", "C0075007#ent", "<e1>", "with", "enalapril", ",", "lisinopril", ",", "C0076891#ent", "<e2>", "or", "captopril", ",", "C0075007#ent", "<e1>", "was", "at", "least", "as", "effective", "as", "the", "other", "substances", "."], "h": {"id": "C0076891", "name": "C0076891#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0075007", "name": "C0075007#ent", "pos": [6, 7]}}
{"token": ["The", "F", "promoter", "a", "putative", "C1321914#ent", "<e1>", "AP-1", "site", ",", "but", "C0087140#ent", "<e2>", "activation", "was", "unremarkable", "in", "over-confluent", "cells", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [11, 12]}}
{"token": ["The", "commitment", "stage", "C1321914#ent", "<e1>", "macrophage", "differentiation", "was", "associated", "with", "increases", "in", "jun", "B", "C0087140#ent", "<e2>", "mRNA", "levels", ",", "as", "well", "as", "with", "an", "increase", "in", "the", "binding", "activity", "transcription", "factor", "AP-1", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [14, 15]}}
{"token": ["Silibinin", "has", "been", "found", "to", "inhibit", "C1321914#ent", "<e1>", "MMP-9", "gene", "transcriptional", "activity", "blocking", "the", "activation", "of", "C0087140#ent", "<e2>", "via", "MAPK", "signaling", "pathways"], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [16, 17]}}
{"token": ["Other", "locations", "include", "the", "interleukin-1", "alpha", "C1708431#ent", "<e1>", "or", "their", "promoters", ")", "or", "C0029016#ent", "<e2>", "."], "h": {"id": "C1708431", "name": "C1708431#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [13, 14]}}
{"token": ["The", "similarities", "between", "canine", "C0019158#ent", "<e1>", "and", "human", "C0042721#ent", "<e2>", "that", "canine", "C0019158#ent", "<e1>", "may", "have", "a", "viral", "etiology", "."], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [4, 5]}}
{"token": ["Subsequently", ",", "these", "C0035064#ent", "<e1>", "were", "evaluated", "in", "an", "animal", "model", "C0004031#ent", "<e2>", "A.", "fumigatus", "test", "organism"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004031", "name": "C0004031#ent", "pos": [11, 12]}}
{"token": ["Further", ",", "neither", "wild", "type", "dominant", "negative", "C1704839#ent", "<e1>", "had", "effects", "on", "constitutive", "C1412336#ent", "<e2>", "expression", "in", "corneal", "epithelial", "cells"], "h": {"id": "C1704839", "name": "C1704839#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412336", "name": "C1412336#ent", "pos": [13, 14]}}
{"token": ["The", "deduced", "C2917660#ent", "<e1>", "of", "the", "C3889284#ent", "<e2>", "and", "ethB", "genes", "were", "found", "to", "be", "homologous", "to", "those", "of", "the", "haemolysin", "and", "activation/secretion", "proteins", "of", "Haemophilus", "ducreyi", "Proteus", "mirabilis", "and", "Serratia", "marcescens"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889284", "name": "C3889284#ent", "pos": [6, 7]}}
{"token": ["After", "nine", "years", ",", "a", "boy", "was", "cured", "for", "his", "presumed", "C0015397#ent", "<e1>", "microsurgical", "removal", "intraocular", "sand", "particles", ",", "left", "in", "the", "C0020641#ent", "<e2>", "a", "childhood", "trauma"], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0020641", "name": "C0020641#ent", "pos": [22, 23]}}
{"token": ["C0015397#ent", "<e1>", "such", "as", "Krukenberg's", "spindle", "hyphema", ",", "and", "C0020641#ent", "<e2>", ",", "are", "related", "to", "the", "deposition", "of", "specific", "particles", "such", "as", "pigmentary", "cells", ",", "leukocytes", ",", "and", "erythrocytes", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0020641", "name": "C0020641#ent", "pos": [9, 10]}}
{"token": ["The", "membrane-associated", "mucin", "C2346918#ent", "<e1>", ",", "a", "heavily", "C1415205#ent", "<e2>", "is", "expressed", "by", "the", "ocular", "surface", "epithelia", "and", "localized", "on", "the", "tips", "of", "the", "surface", "microplicae", "."], "h": {"id": "C2346918", "name": "C2346918#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415205", "name": "C1415205#ent", "pos": [8, 9]}}
{"token": ["Appetite", "suppressants", "C0028362#ent", "<e1>", ",", "dexfenfluramine", ",", "and", "C0031447#ent", "<e2>", "have", "been", "used", "alone", "or", "in", "combination", "as", "an", "alternative", "to", "diet", "and", "surgery", "in", "the", "management", "of", "obesity", "."], "h": {"id": "C0028362", "name": "C0028362#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031447", "name": "C0031447#ent", "pos": [8, 9]}}
{"token": ["To", "estimate", "the", "incidence", "of", "newly", "diagnosed", "idiopathic", "stroke", "users", "of", "C0028362#ent", "<e1>", ",", "dexfenfluramine", "and", "C0031447#ent", "<e2>", "compared", "to", "obese", "nonusers", "."], "h": {"id": "C0028362", "name": "C0028362#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031447", "name": "C0031447#ent", "pos": [16, 17]}}
{"token": ["With", "the", "recent", "withdrawal", "of", "C0028362#ent", "<e1>", "from", "the", "market", ",", "many", "people", "have", "begun", "combining", "C0031447#ent", "<e2>", "with", "fluoxetine", ",", "a", "serotonin", "reuptake", "inhibitor", "also", "produces", "mild", "anorectic", "effects", "."], "h": {"id": "C0028362", "name": "C0028362#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031447", "name": "C0031447#ent", "pos": [16, 17]}}
{"token": ["C0024449#ent", "<e1>", "is", "a", "tropical", "superficial", "C0026946#ent", "<e2>", "endemic", "in", "parts", "of", "Africa"], "h": {"id": "C0024449", "name": "C0024449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [6, 7]}}
{"token": ["Our", "recent", "studies", "have", "demonstrated", "that", "in", "response", "to", "lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "challenge", ",", "alveolar", "epithelial", "cells", "tumor", "necrosis", "factor", ",", "an", "C1705964#ent", "<e2>", "cytokine", "in", "the", "inflammatory", "process"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705964", "name": "C1705964#ent", "pos": [24, 25]}}
{"token": ["To", "learn", "more", "about", "these", "inhibitory", "mechanisms", ",", "we", "studied", "the", "effects", "of", "C2697656#ent", "<e1>", "and", "dLPS", "on", "an", "C1705964#ent", "<e2>", "the", "C2697656#ent", "<e1>", "signal", "pathway", "protein", "tyrosine", "phosphorylation"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705964", "name": "C1705964#ent", "pos": [19, 20]}}
{"token": ["The", "present", "study", "was", "designed", "to", "test", "the", "hypothesis", "that", "lung", "damage", "either", "by", "ozone", "or", "lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "occurs", "through", "distinct", "C1705964#ent", "<e2>", "which", "are", "age", "dependent", "the", "postnatal", "lung", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705964", "name": "C1705964#ent", "pos": [24, 25]}}
{"token": ["No", "apparent", "changes", "were", "observed", "between", "controls", "and", "C0012772#ent", "<e1>", "in", "levels", "of", "C1422070#ent", "<e2>", "in", "all", "brain", "regions", "."], "h": {"id": "C0012772", "name": "C0012772#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [13, 14]}}
{"token": ["We", "provide", "evidence", "that", "USF", "binds", "to", "C1822681#ent", "<e1>", ",", "whereas", "we", "were", "unable", "to", "detect", "the", "C0812382#ent", "<e2>", "MITF", "."], "h": {"id": "C1822681", "name": "C1822681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [17, 18]}}
{"token": ["To", "eliminate", "the", "possibility", "that", "the", "Yrk", "protein", "is", "an", "avian", "C1334043#ent", "<e1>", "of", "mammalian", "C1442788#ent", "<e2>", ",", "we", "isolated", "and", "sequenced", "the", "chicken", "fyn", "cDNA", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [15, 16]}}
{"token": ["The", "techniques", "herein", "described", "allow", "in", "vitro", "quantitation", "of", "some", "of", "the", "mechanisms", "by", "which", "HIV", "infection", "C1258847#ent", "<e1>", "may", "contribute", "to", "the", "C0021051#ent", "<e2>", "associated", "with", "AIDS", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [23, 24]}}
{"token": ["C1335554#ent", "<e1>", "PTPN5", ",", "PTPRR", "and", "C1571063#ent", "<e2>", "comprise", "a", "family", "of", "phosphatases", "that", "specifically", "inactivate", "MAPKs", "(", "mitogen-activated", "protein", "kinases", "."], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1571063", "name": "C1571063#ent", "pos": [6, 7]}}
{"token": ["In", "CF", "and", "C0751434#ent", "<e1>", "the", "chromosome", "carrying", "the", "C0019247#ent", "<e2>", "identified", "by", "the", "molecular", "probe", "while", "in", "CAH", "it", "can", "also", "be", "determined", "by", "HLA", "phenotyping"], "h": {"id": "C0751434", "name": "C0751434#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [9, 10]}}
{"token": ["C0751434#ent", "<e1>", "(", "PKU", ")", "is", "a", "C0019247#ent", "<e2>", "autosomal", "recessive", "inheritance", "."], "h": {"id": "C0751434", "name": "C0751434#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["The", "C1414471#ent", "<e1>", "variant", "of", "the", "C1708797#ent", "<e2>", "necessary", "and", "sufficient", "for", "cancer", "cell", "survival"], "h": {"id": "C1414471", "name": "C1414471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1708797", "name": "C1708797#ent", "pos": [6, 7]}}
{"token": ["A", "38", "year", "old", "woman", "was", "admitted", "because", "of", "a", "C0030193#ent", "<e1>", "right", "supraclavicular", "mass", "dyspnea", "on", "exertion", "and", "C0011168#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [19, 20]}}
{"token": ["In", "spite", "of", "the", "presence", "of", "the", "highly", "soluble", "C1417057#ent", "<e1>", "as", "the", "fusion", "partner", ",", "the", "C3889446#ent", "<e2>", "MBP-Rep", "fusion", "protein", "formed", "insoluble", "inclusion", "bodies"], "h": {"id": "C1417057", "name": "C1417057#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [17, 18]}}
{"token": ["Although", "fusion", "proteins", "to", "LKB1", "with", "6xHis", ",", "GST", "and", "C1417057#ent", "<e1>", "tags", "could", "be", "C3889446#ent", "<e2>", "in", "E.", "coli", "only", "MBP-LKB1", "was", "recovered", "in", "a", "soluble", ",", "but", "heavily", "degraded", "form", "."], "h": {"id": "C1417057", "name": "C1417057#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [15, 16]}}
{"token": ["The", "heparin-dependent", "plasma", "serpins", ",", "antithrombin", ",", "C1415492#ent", "<e1>", "protein", "C", "inhibitor", "regulate", "the", "C0030940#ent", "<e2>", "of", "blood", "coagulation"], "h": {"id": "C1415492", "name": "C1415492#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [14, 15]}}
{"token": ["She", ",", "then", ",", "fell", "into", "C0796110#ent", "<e1>", "years", "later", ",", "and", "died", "of", "C0032285#ent", "<e2>", "at", "the", "age", "of", "53", "."], "h": {"id": "C0796110", "name": "C0796110#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [14, 15]}}
{"token": ["Dementia", "developed", "nine", "months", "after", "the", "onset", "of", "the", "disease", ",", "and", "the", "patient", "manifested", "C0796110#ent", "<e1>", "21", "months", "and", "died", "of", "C0032285#ent", "<e2>", "at", "about", "25", "months", "."], "h": {"id": "C0796110", "name": "C0796110#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [22, 23]}}
{"token": ["Acute", "pancreatitis", "result", "from", "C0042769#ent", "<e1>", "including", "mumps", ",", "coxsackie", "B", "Epstein-Barr", ",", "and", "C0008049#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0008049", "name": "C0008049#ent", "pos": [14, 15]}}
{"token": ["Certain", "cutaneous", "C0042769#ent", "<e1>", "such", "as", "Herpes", "simplex", "vaccinia", "and", "C0008049#ent", "<e2>", "known", "to", "occasionally", "run", "an", "usually", "severe", "course", "in", "AD", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0008049", "name": "C0008049#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "in", "animal", "models", "analogous", "to", "the", "C0020625#ent", "<e1>", "forms", "seen", "in", "humans", ",", "C1176308#ent", "<e2>", "presents", "exciting", "therapeutic", "implications", "in", "the", "management", "of", "patients", "with", "severe", "C0020625#ent", "<e1>", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C1176308", "name": "C1176308#ent", "pos": [15, 16]}}
{"token": ["It", "is", "concluded", "that", "C0033036#ent", "<e1>", "is", "the", "cause", "of", "this", "C0398623#ent", "<e2>"], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [11, 12]}}
{"token": ["These", "inborn", "errors", "associated", "with", "wide", "variety", "of", "clinical", "symptoms", "biochemical", "profiles", "persistent", "hyperlysinemia", ",", "C2936921#ent", "<e1>", ",", "\"", "amino", "and", "ketoadipic", "aciduria", "and", "C0268595#ent", "<e2>"], "h": {"id": "C2936921", "name": "C2936921#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0268595", "name": "C0268595#ent", "pos": [24, 25]}}
{"token": ["However", ",", "C0008294#ent", "<e1>", "and", "lisinopril", "were", "more", "effective", "at", "preventing", "C0018802#ent", "<e2>", "whereas", "amlodipine", "and", "C0008294#ent", "<e1>", "were", "more", "effective", "than", "lisinopril", "at", "preventing", "stroke", "."], "h": {"id": "C0008294", "name": "C0008294#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}}
{"token": ["The", "apo", "AI", "induced", "decrease", "of", "C0082645#ent", "<e1>", "expression", "was", "paralleled", "by", "the", "reduction", "of", "active", "GTP-bound", "C1366537#ent", "<e2>", "."], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366537", "name": "C1366537#ent", "pos": [17, 18]}}
{"token": ["Here", ",", "for", "the", "first", "time", ",", "we", "examine", "the", "functions", "of", "C0082645#ent", "<e1>", "in", "developing", "tissues", "using", "loss-of-function", "mutations", "in", "the", "Drosophila", "C1366537#ent", "<e2>"], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366537", "name": "C1366537#ent", "pos": [23, 24]}}
{"token": ["To", "investigate", "whether", "the", "distinctive", "characteristics", "of", "hyphae", "are", "due", "to", "increased", "activity", "of", "the", "C0082645#ent", "<e1>", "strains", "lacking", "negative", "regulators", "C1366537#ent", "<e2>", "were", "constructed", "."], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366537", "name": "C1366537#ent", "pos": [21, 22]}}
{"token": ["One", "enzyme", "that", "initiates", "base", "excision", "repair", "ring-fragmented", "purines", "and", "some", "saturated", "pyrimidines", "C1425521#ent", "<e1>", ",", "a", "mammalian", "homolog", "to", "C1122828#ent", "<e2>"], "h": {"id": "C1425521", "name": "C1425521#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1122828", "name": "C1122828#ent", "pos": [20, 21]}}
{"token": ["Pbx1", "is", "a", "homeodomain", "transcription", "factor", "in", "C0010531#ent", "<e1>", "transcriptional", "regulation", "the", "bovine", "C1706114#ent", "<e2>"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706114", "name": "C1706114#ent", "pos": [13, 14]}}
{"token": ["We", "also", "investigated", "the", "effect", "of", "IFN-gamma", "on", "the", "expression", "of", "various", "C1332664#ent", "<e1>", "as", "the", "Fas/TNF-related", "genes", ",", "the", "bcl-2", "family", "and", "the", "C1332858#ent", "<e2>"], "h": {"id": "C1332664", "name": "C1332664#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332858", "name": "C1332858#ent", "pos": [24, 25]}}
{"token": ["The", "relatively", "low", "doses", "of", "E2", "used", "here", "fail", "to", "alter", "C3274756#ent", "<e1>", "specific", "activity", "in", "C0032002#ent", "<e2>", "or", "brain", "."], "h": {"id": "C3274756", "name": "C3274756#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [16, 17]}}
{"token": ["Knockdown", "of", "C1417371#ent", "<e1>", "by", "RNA", "interference", "resulted", "in", "enhanced", "infection", ",", "suggesting", "that", "even", "the", "endogenous", "basal", "levels", "of", "C1417371#ent", "<e1>", "in", "rat", "fibroblasts", "are", "sufficient", "to", "limit", "C0042769#ent", "<e1>"], "h": {"id": "C1417371", "name": "C1417371#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [29, 30]}}
{"token": ["The", "functional", "relationship", "between", "MCP", "and", "C1417371#ent", "<e1>", "in", "a", "C0042769#ent", "<e2>", "discussed", "."], "h": {"id": "C1417371", "name": "C1417371#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [10, 11]}}
{"token": ["The", "unique", "aspect", "of", "this", "study", "is", "the", "finding", "that", "C0008273#ent", "<e1>", "did", "not", "abolish", "the", "C0020538#ent", "<e2>", "action", "of", "salt", "in", "S", "rats", "."], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["However", ",", "population", "evidence", "does", "not", "support", "the", "general", "avoidance", "of", "C0008273#ent", "<e1>", "or", "beta-antagonists", "in", "C0020538#ent", "<e2>"], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["High", "concentration", ">", "5", "mM", ")", "of", "adenosine", "in", "C0059905#ent", "<e1>", "EC", ")", "remarkably", "increased", "C2744579#ent", "<e2>", "and", "total", "adenine", "nucleotide", "TAN", ")", "levels", "during", "24", "hr", "preservation", "by", "the", "two-layer", "method", "using", "EC", "."], "h": {"id": "C0059905", "name": "C0059905#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [15, 16]}}
{"token": ["The", "patient", "was", "readmitted", ",", "aged", "4", "weeks", ",", "with", "C0220994#ent", "<e1>", "(", "347", "\u03bcmol/L", ")", "and", "again", "this", "responded", "to", "C1318649#ent", "<e2>", "."], "h": {"id": "C0220994", "name": "C0220994#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C1318649", "name": "C1318649#ent", "pos": [21, 22]}}
{"token": ["In", "conclusion", ",", "C0020538#ent", "<e1>", "interferes", "in", "lipid", "metabolism", "reducing", "LPL", "activity", "in", "adipose", "tissue", "while", "C0287041#ent", "<e2>", "administration", "reverses", "this", "effect", "by", "enhancing", "insulin", "release", "and", "reducing", "sympathetic", "nervous", "system", "SNS", ")", "stimulation", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [16, 17]}}
{"token": ["It", "is", "concluded", "that", "ASA", "counteracts", "the", "excitatory", "effects", "of", "C0006931#ent", "<e1>", "on", "nociceptors", "and", "mechanical", "hyperalgesia", "not", "its", "C0162830#ent", "<e2>", "action", "to", "heat", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162830", "name": "C0162830#ent", "pos": [19, 20]}}
{"token": ["Polyclonal", "antibody", "against", "human", "C0059563#ent", "<e1>", "enzymes", "inhibited", "formation", "of", "DMTOR", "and", "C3539732#ent", "<e2>", "III", "by", "60", "and", "46", "%", ",", "respectively", "."], "h": {"id": "C0059563", "name": "C0059563#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539732", "name": "C3539732#ent", "pos": [12, 13]}}
{"token": ["Various", "physiological", "imbalances", "lead", "to", "reactive", "oxygen", "species", "ROS", ")", "C0221406#ent", "<e1>", "and/or", "increases", "in", "C0023837#ent", "<e2>", "(", "LOX", ")", "activities", ",", "both", "events", "ending", "in", "lipid", "peroxidation", "polyunsaturated", "fatty", "acids", "PUFAs", ")", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [15, 16]}}
{"token": ["All", "of", "these", "results", "suggest", "that", "an", "C0221406#ent", "<e1>", "of", "leukotrienes", "and", "other", "C0023837#ent", "<e2>", "following", "cyclooxygenase", "blockade", "induced", "by", "NSAIDs", ",", "may", "play", "a", "role", "in", "the", "development", "of", "gastric", "mucosal", "damage"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [13, 14]}}
{"token": ["In", "summary", ",", "antecedent", "hypoglycemia", "impaired", "C0267963#ent", "<e1>", "responsiveness", "to", "subsequent", "hypotension", "despite", "no", "reduction", "in", "adrenal", "C2984121#ent", "<e2>", "and", "in", "association", "with", "reduced", "adrenal", "C0267963#ent", "<e1>", "content", "."], "h": {"id": "C2984121", "name": "C2984121#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0267963", "name": "C0267963#ent", "pos": [6, 7]}}
{"token": ["p54", "and", "C1419020#ent", "<e1>", "are", "highly", "C1512488#ent", "<e2>", "and", "are", "smaller", "than", "expected", "by", "SDS/PAGE", "(", "36", "kDa", "and", "37", "kDa", ")", "due", "to", "anomalous", "electrophoretic", "mobility"], "h": {"id": "C1419020", "name": "C1419020#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}}
{"token": ["C0003949#ent", "<e1>", "and", "silicosis", "are", "C0016034#ent", "<e2>", "by", "the", "inhalation", "of", "silica-containing", "dusts", ",", "asbestos", "and", "quartz", "."], "h": {"id": "C0003949", "name": "C0003949#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016034", "name": "C0016034#ent", "pos": [5, 6]}}
{"token": ["The", "combination", "of", "C0008809#ent", "<e1>", "and", "azlocillin", "was", "synergistic", "in", "rats", "with", "C0033817#ent", "<e2>"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0033817", "name": "C0033817#ent", "pos": [12, 13]}}
{"token": ["The", "Cystic", "Fibrosis", "Clinic", "at", "the", "Royal", "Belfast", "Hospital", "for", "Sick", "Children", "treated", "31", "children", "with", "C0008809#ent", "<e1>", ",", "for", "serious", "C0033817#ent", "<e2>", "cystic", "fibrosis", "and", "carefully", "monitored", "the", "safety", "and", "acceptability", "of", "the", "drug", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0033817", "name": "C0033817#ent", "pos": [21, 22]}}
{"token": ["Prominent", "changes", "of", "the", "AM", "phenotype", "were", "found", "in", "active", "sarcoidosis", "C0400822#ent", "<e1>", "with", "more", "frequent", "expression", "of", "CD54", ",", "KiM2", ",", "C1705610#ent", "<e2>", ",", "CD11b", "and", "RFD9", "."], "h": {"id": "C0400822", "name": "C0400822#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705610", "name": "C1705610#ent", "pos": [22, 23]}}
{"token": ["We", "present", "two", "patients", "who", "developed", "de", "novo", "C0156147#ent", "<e1>", "and", "three", "years", "after", "liver", "transplant", "primary", "biliary", "cirrhosis", "PBC", ")", "and", "C0524909#ent", "<e2>", "respectively", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [22, 23]}}
{"token": ["Lesser", "elevations", "in", "Sj\u00f6gren's", "syndrome", "rheumatoid", "arthritis", "ankylosing", "spondylitis", "and", "C0156147#ent", "<e1>", "but", "none", "with", "C0524909#ent", "<e2>"], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [15, 16]}}
{"token": ["Scleroderma", "renal", "crisis", "SRC", ")", "was", "known", "as", "a", "rare", "and", "catastrophic", "syndrome", "responsible", "for", "C3854173#ent", "<e1>", "ARF", ")", "in", "a", "context", "of", "widespread", "C0042373#ent", "<e2>", "in", "progressive", "systemic", "sclerosis", "PSS", ")", "."], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [24, 25]}}
{"token": ["Thirty-eight", "had", "chronic", "glomerulonephritis", "12", "renal", "calculi", "nine", "diabetic", "renal", "disease", "seven", "chronic", "pyelonephritis", "five", "sequelae", "of", "C3854173#ent", "<e1>", "ARF", ")", ",", "four", "C0042373#ent", "<e2>", "three", "polycystic", "disease", "the", "kidneys", ",", "and", "two", "obstructive", "uropathy"], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [23, 24]}}
{"token": ["Pseudomonas", "aeruginosa-derived", "alginate", "but", "no", "other", "neutral", "and", "negatively", "C0032594#ent", "<e1>", "mucoid", "and", "nonmucoid", "strains", "of", "that", "organism", "against", "C0008809#ent", "<e2>", ",", "gentamicin", ",", "ticarcillin", ",", "and", "ceftazidime", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", "the", "C0242209#ent", "<e1>", "composition", "of", "podocalyxin", "was", "determined", "in", "puromycin", "aminonucleoside-treated", "(", "C3887654#ent", "<e2>", ")", "rats", "and", "controls", "."], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887654", "name": "C3887654#ent", "pos": [15, 16]}}
{"token": ["Even", "more", "important", ",", "C1420200#ent", "<e1>", "despite", "the", "C0011991#ent", "<e2>", "cholera", "and", "enterotoxigenic", "E.", "coli", "after", "intestinal", "damage", "to", "rotavirus", "."], "h": {"id": "C1420200", "name": "C1420200#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [8, 9]}}
{"token": ["All", "the", "serotonin", "5-HT(1B/1D", ")", "receptor", "agonists", "(", "triptans", ")", "are", "available", "as", "oral", "tablets", "sumatriptan", ",", "rizatriptan", ",", "C0528166#ent", "<e1>", ",", "naratriptan", ",", "almotriptan", ",", "C0754647#ent", "<e2>", "and", "eletriptan", ")", "."], "h": {"id": "C0528166", "name": "C0528166#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0754647", "name": "C0754647#ent", "pos": [26, 27]}}
{"token": ["Alternatively", ",", "targeting", "the", "mechanisms", "up-stream", "of", "C1565306#ent", "<e1>", "leading", "to", "deregulation", "of", "C1565306#ent", "<e1>", "activity", ",", "such", "as", "proteolytic", "cleavage", "its", "activating", "C0599220#ent", "<e1>", "may", "prove", "to", "be", "more", "beneficial", "as", "a", "therapeutical", "approach"], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [23, 24]}}
{"token": ["The", "neuronal", "cyclin-dependent", "kinase", "p35/cdk5", "comprises", "a", "catalytic", "subunit", "C1565306#ent", "<e1>", ")", "and", "an", "C0599220#ent", "<e2>", "p35", ")", "."], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [14, 15]}}
{"token": ["Originally", "described", "as", "an", "C1413096#ent", "<e1>", "in", "patients", "with", "C0035435#ent", "<e2>", "the", "La", "protein", "binds", "to", "newly", "synthesized", "RNA", "polymerase", "III", "transcripts", "."], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [9, 10]}}
{"token": ["The", "C2931914#ent", "<e1>", "occur", "not", "only", "as", "a", "subtype", "of", "C0013421#ent", "<e2>", "also", "as", "a", "subtype", "of", "tardive", "dystonia"], "h": {"id": "C2931914", "name": "C2931914#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013421", "name": "C0013421#ent", "pos": [10, 11]}}
{"token": ["A", "34-year-old", "male", "with", "C0221775#ent", "<e1>", "surgery", "was", "placed", "on", "C0060926#ent", "<e2>", "daily", "for", "chronic", "back", "pain"], "h": {"id": "C0221775", "name": "C0221775#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [10, 11]}}
{"token": ["Immunogold", "studies", "of", "normal", "human", "kidney", "and", "common", "human", "kidney", "cancers", "performed", "using", "polyclonal", "antibodies", "antioxidant", "enzymes", "including", "antibodies", "to", "copper", ",", "zinc", "and", "C1743497#ent", "<e1>", "catalase", ",", "glutathione", "peroxidase", "and", "glutathione", "S-transferases", "their", "C0599220#ent", "<e2>", "."], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [34, 35]}}
{"token": ["Bovine", "erythrocyte", "superoxide", "dismutase", "Cu(2)Zn(2)SODase", ";", "superoxide", ":", "superoxide", "oxidoreductase", "C1743497#ent", "<e1>", "consists", "of", "two", "identical", "C0599220#ent", "<e2>", "each", "containing", "Cu(2+)", "Zn(2", "+", ")", "in", "close", "proximity", "."], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}}
{"token": ["Progestin", "use", "appears", "to", "attenuate", "the", "effect", "of", "oral", "estrogen", "C1413766#ent", "<e1>", "and", "is", "associated", "with", "reduction", "in", "C1439335#ent", "<e2>"], "h": {"id": "C1413766", "name": "C1413766#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1439335", "name": "C1439335#ent", "pos": [18, 19]}}
{"token": ["Doxorubicin", "(", "C0393003#ent", "<e1>", ")", ",", "used", "for", "chemoembolization", "of", "C1415491#ent", "<e2>", ",", "is", "poorly", "efficacious", "when", "administered", "systemically", "at", "conventional", "doses", "dose", "escalation", "is", "hindered", "by", "unacceptable", "toxicity", "."], "h": {"id": "C0393003", "name": "C0393003#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415491", "name": "C1415491#ent", "pos": [10, 11]}}
{"token": ["Obesity", "caused", "by", "excess", "nutrition", "or", "excess", "storage", "of", "C1428607#ent", "<e1>", "relative", "to", "energy", "expenditure", "a", "form", "of", "C0022806#ent", "<e2>", "that", "is", "increasingly", "seen", "in", "children", "."], "h": {"id": "C1428607", "name": "C1428607#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022806", "name": "C0022806#ent", "pos": [18, 19]}}
{"token": ["Phosphorylation", "of", "C1418938#ent", "<e1>", "by", "endogenous", "C0033640#ent", "<e2>", "isolated", "secretory", "granules", "shown", "to", "result", "in", "the", "production", "of", "both", "phosphoserine", "and", "phosphothreonine", "residues"], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [6, 7]}}
{"token": ["C1418938#ent", "<e1>", "and", "the", "inhibitors", "of", "C0033640#ent", "<e2>", "then", "added", "to", "the", "culture", "medium"], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [6, 7]}}
{"token": ["This", "change", "is", "independent", "of", "HPA", "axis", "activation", "4", "days", "after", "TNBS", "treatment", "but", "is", "associated", "with", "increased", "circulating", "C0812246#ent", "<e1>", ",", "suggestive", "of", "an", "exaggerated", "immune", "response", "adults", "exposed", "to", "C0854706#ent", "<e2>"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0854706", "name": "C0854706#ent", "pos": [31, 32]}}
{"token": ["Both", "the", "growth", "defect", "the", "actin", "organisation", "defect", "of", "the", "C1415619#ent", "<e1>", "-", "2ts", "mutant", "were", "suppressed", "by", "upregulation", "of", "C3538849#ent", "<e2>", "but", "not", "by", "upregulation", "of", "Bni1", ",", "Fks", "or", "Skn7", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3538849", "name": "C3538849#ent", "pos": [20, 21]}}
{"token": ["C3538849#ent", "<e1>", "co-immunoprecipitates", "with", "C1415619#ent", "<e2>", "in", "yeast", "extracts", ",", "and", "recombinant", "C1415619#ent", "<e2>", "associates", "with", "C3538849#ent", "<e1>", "in", "vitro", "a", "GTP-dependent", "manner", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538849", "name": "C3538849#ent", "pos": [0, 1]}}
{"token": ["The", "modern", "quantitative", "methods", "are", "sensitive", "and", "accurate", "thus", "providing", "important", "information", "in", "the", "evaluation", "of", "various", "C0027765#ent", "<e1>", "particularly", "in", "the", "diagnosis", "of", "C0027868#ent", "<e2>"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [24, 25]}}
{"token": ["It", "is", "concluded", "that", "C0012739#ent", "<e1>", "the", "microcirculation", "of", "the", "intestinal", "mucosa", "as", "well", "as", "C0030286#ent", "<e2>", "play", "a", "role", "in", "the", "pathogenesis", "of", "hemorrhagic", "necrosis", "the", "intestine", "associated", "with", "DIC", "."], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030286", "name": "C0030286#ent", "pos": [15, 16]}}
{"token": ["Antimalarials", "are", "used", "in", "numerous", "C0004364#ent", "<e1>", "the", "most", "frequent", "of", "which", "are", "rheumatoid", "arthritis", "C0409974#ent", "<e2>"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0409974", "name": "C0409974#ent", "pos": [15, 16]}}
{"token": ["More", "recently", ",", "we", "have", "found", "a", "similar", "behavior", "in", "models", "with", "C0004364#ent", "<e1>", "that", "is", ",", "murine", "C0409974#ent", "<e2>", "avian", "scleroderma"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0409974", "name": "C0409974#ent", "pos": [18, 19]}}
{"token": ["Application", "of", "the", "software", "to", "the", "study", "of", "the", "3-D", "structure", "C1136365#ent", "<e1>", "the", "nucleolus", "stained", "with", "C0947651#ent", "<e2>", "is", "shown", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0947651", "name": "C0947651#ent", "pos": [17, 18]}}
{"token": ["The", "experimental", "animals", "divided", "into", "four", "groups", "(", "control", ",", "C1822779#ent", "<e1>", "alone", ",", "C0020550#ent", "<e2>", ",", "and", "C0020550#ent", "<e2>", "+", "C1822779#ent", "<e1>", ")", "."], "h": {"id": "C1822779", "name": "C1822779#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [14, 15]}}
{"token": ["This", "inhibition", "of", "C0387583#ent", "<e1>", "induction", "occurs", "transcriptionally", "as", "a", "result", "of", "C2984537#ent", "<e2>", "repression", "of", "NF-kappaB", "signalling"], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2984537", "name": "C2984537#ent", "pos": [12, 13]}}
{"token": ["The", "ET-1-induced", "Ca2", "+", "C0246719#ent", "<e1>", "was", "completely", "blocked", "by", "the", "selective", "C1414262#ent", "<e2>", "antagonist", "BQ123", ",", "but", "only", "slightly", "diminished", "by", "extracellular", "application", "of", "2", "mM", "EGTA", "."], "h": {"id": "C0246719", "name": "C0246719#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414262", "name": "C1414262#ent", "pos": [12, 13]}}
{"token": ["The", "GnRH", "agonists", "on", "the", "market", "have", "been", "shown", "to", "work", "quite", "well", "in", "reducing", "all", "C0030193#ent", "<e1>", "associated", "with", "endometriosis", ",", "including", "dysmenorrhea", ",", "dyspareunia", ",", "and", "C0030794#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0030794", "name": "C0030794#ent", "pos": [28, 29]}}
{"token": ["Neovascularization", "and", "C1705526#ent", "<e1>", ",", "VEGF", ",", "and", "C1336626#ent", "<e2>", "expressions", "of", "tumorous", "tissue", "higher", "than", "non-tumorous", "tissue", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336626", "name": "C1336626#ent", "pos": [8, 9]}}
{"token": ["Restoration", "of", "C1705526#ent", "<e1>", "expression", "in", "these", "tumors", "re-established", "C1336626#ent", "<e2>", "expression", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336626", "name": "C1336626#ent", "pos": [9, 10]}}
{"token": ["In", "seven", "patients", "(", "47", "%", ")", "the", "C0042749#ent", "<e1>", "was", "negative", "before", "the", "C0071561#ent", "<e2>", "(", "median", "10.7", "days", ")", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0071561", "name": "C0071561#ent", "pos": [14, 15]}}
{"token": ["The", "purpose", "of", "this", "work", "was", "to", "establish", "a", "controlled", "and", "reversible", "muscle", "weakness", "model", "for", "studying", "the", "effects", "of", "C0427055#ent", "<e1>", "on", "joint", "degeneration", "to", "C0029408#ent", "<e2>", "(", "OA", ")", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [26, 27]}}
{"token": ["Fifty", "patients", "had", "fever", ",", "43", "had", "a", "regurgitating", "murmur", "28", "C0427055#ent", "<e1>", "and", "weight-loss", ",", "13", "cutaneous", "lesions", ",", "11", "C0029408#ent", "<e2>", ",", "8", "splenomegaly", ",", "3", "ocular", "lesions", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [21, 22]}}
{"token": ["Hereditary", "defects", "early", "components", "of", "the", "classical", "pathway", "C1", ",", "C4", ",", "C2", "-", "are", "often", "associated", "with", "diseases", "of", "the", "immuncomplex-type", "especially", "with", "systemic", "lupus", "erythematosus", "C0221056#ent", "<e1>", ",", "vasculitis", "and", "C0031065#ent", "<e2>", "."], "h": {"id": "C0221056", "name": "C0221056#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0031065", "name": "C0031065#ent", "pos": [32, 33]}}
{"token": ["Aside", "from", "these", ",", "one", "mother", "had", "C0001403#ent", "<e1>", "she", "used", "long-term", "C0011777#ent", "<e2>", "during", "her", "pregnancy", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}}
{"token": ["The", "human", "C1367710#ent", "<e1>", "formyl", "peptide", "receptor", "genes", "as", "well", "as", "two", "C0017337#ent", "<e2>", "with", "high", "sequence", "to", "the", "formyl", "peptide", "receptor", "FPRH1", "and", "FPRH2", ",", "have", "been", "mapped", "to", "chromosome", "19", "Lu", "et", "al.", ",", "1992", ")", "."], "h": {"id": "C1367710", "name": "C1367710#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "strengthen", "C1620114#ent", "<e1>", "and", "CDK13", "as", "a", "subfamily", "of", "C0080054#ent", "<e2>", "regulate", "alternative", "splicing", "."], "h": {"id": "C1620114", "name": "C1620114#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [11, 12]}}
{"token": ["C0235025#ent", "<e1>", "myalgia", "were", "significantly", "more", "common", "in", "the", "C1418943#ent", "<e2>", "P<0.001", ")", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [9, 10]}}
{"token": ["Intravenous", "phenytoin", "sodium", "C0282303#ent", "<e1>", "definitive", ",", "long-term", "control", "of", "C0014549#ent", "<e2>", "must", "be", "administered", "slowly", "and", "require", "time", "to", "reach", "peak", "brain", "concentrations", "."], "h": {"id": "C0282303", "name": "C0282303#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [10, 11]}}
{"token": ["Silybum", "marianum", "flavonolignans", ",", "termed", "C0037135#ent", "<e1>", "(", "SM", ")", ",", "that", "are", "therapeutic", "agents", "many", "inflammation-based", "diseases", "C0004153#ent", "<e2>", "."], "h": {"id": "C0037135", "name": "C0037135#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [18, 19]}}
{"token": ["The", "MCA", "removed", "the", "previous", "exemption", "from", "regulation", "as", "List", "I", "chemicals", "had", "applied", "to", "pseudoephedrine", ",", "C0031495#ent", "<e1>", ",", "and", "combination", "C0014479#ent", "<e2>", "drug", "products"], "h": {"id": "C0031495", "name": "C0031495#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014479", "name": "C0014479#ent", "pos": [22, 23]}}
{"token": ["A", "C0221166#ent", "<e1>", "which", "consisted", "at", "first", "of", "a", "transient", "C0085620#ent", "<e2>", "1", "to", "5", "hr", "followed", "by", "a", "permanent", "flaccid", "paralysis", "which", "developed", "after", "24", "to", "36", "hr", "."], "h": {"id": "C0221166", "name": "C0221166#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085620", "name": "C0085620#ent", "pos": [10, 11]}}
{"token": ["C1519709#ent", "<e1>", "early", "in", "childhood", "in", "people", "who", "inherit", "mutations", "in", "C1417679#ent", "<e2>", "that", "mediate", "lymphocyte", "apoptosis", "or", "programmed", "cell", "death"], "h": {"id": "C1519709", "name": "C1519709#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "show", "that", "under", "baseline", "conditions", ",", "Vti", "accounted", "for", "a", "major", "proportion", "of", "C3539667#ent", "<e1>", ";", "during", "both", "passive", "C1167782#ent", "<e2>", "MCh", "challenge", "this", "proportion", "increased", "progressively", "."], "h": {"id": "C3539667", "name": "C3539667#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1167782", "name": "C1167782#ent", "pos": [21, 22]}}
{"token": ["The", "histological", "outcome", "of", "C0524910#ent", "<e1>", "better", "among", "carriers", "of", "the", "apolipoprotein", "E", "ApoE", ")", "epsilon4", "C1706112#ent", "<e2>", ",", "for", "reasons", "unknown", "."], "h": {"id": "C0524910", "name": "C0524910#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [16, 17]}}
{"token": ["The", "data", "demonstrate", "the", "involvement", "of", "C0017337#ent", "<e1>", "from", "the", "fos", "and", "C1623430#ent", "<e2>", "regulation", "of", "MHC", "class", "I", "expression", "and", "consequently", "in", "regulation", "of", "immunogenicity", "and", "metastatic", "competence", "of", "tumor", "cells"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [12, 13]}}
{"token": ["The", "information", "from", "291", "children's", "dental", "charts", "analyzed", ";", "127", "children", "had", "no", "mental", "or", "C0085084#ent", "<e1>", "50", "had", "asthma", "and", "114", "had", "other", "C0029896#ent", "<e2>", "."], "h": {"id": "C0085084", "name": "C0085084#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [24, 25]}}
{"token": ["It", "was", "found", "that", "hyperthyroidism", "had", "no", "effect", "the", "activity", "of", "C0041256#ent", "<e1>", "but", "caused", "a", "modest", "increase", "of", "C1417917#ent", "<e2>", "activity", "at", "10", "days", "of", "age", "."], "h": {"id": "C0041256", "name": "C0041256#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417917", "name": "C1417917#ent", "pos": [19, 20]}}
{"token": ["This", "sequence", "was", "highly", "susceptible", "to", "single-strand", "specific", "endonucleases", "isolated", "from", "Aspergillus", "oryzae", "C0879262#ent", "<e1>", ")", "and", "mung", "bean", "but", "cleavage", "by", "a", "single-strand", "specific", "C0950398#ent", "<e2>", "isolated", "from", "Neurospora", "crassa", "only", "at", "a", "pH", "below", "5.5", "."], "h": {"id": "C0879262", "name": "C0879262#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [25, 26]}}
{"token": ["C0012373#ent", "<e1>", "healing", "of", "chronic", "anal", "fissure", "to", "0.2", "%", "C0731141#ent", "<e2>", "ointment", "but", "was", "associated", "with", "side", "effects"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0731141", "name": "C0731141#ent", "pos": [10, 11]}}
{"token": ["C1419050#ent", "<e1>", ",", "another", "member", "of", "the", "C1333669#ent", "<e2>", "family", ",", "did", "not", "increase", "survival", "with", "target", "delivery", ",", "despite", "its", "retrograde", "transport", "the", "target", "."], "h": {"id": "C1419050", "name": "C1419050#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333669", "name": "C1333669#ent", "pos": [7, 8]}}
{"token": ["Compound", "4", "less", "potent", "beta-adrenoceptor", "C0304402#ent", "<e1>", "activities", "than", "C0072032#ent", "<e2>", "or", "terbutaline", "in", "an", "in", "vitro", "test", "guinea", "pig", "tracheal", "muscle", "right", "atrium"], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0072032", "name": "C0072032#ent", "pos": [9, 10]}}
{"token": ["Linoleic", "acid", "increased", "intracellular", "calcium", "concentration", ",", "which", "was", "blocked", "by", "EGTA", "(", "extracellular", "calcium", "chelator)/BAPTA-AM", "(", "intracellular", "calcium", "chelator", ",", "C1620102#ent", "<e1>", "(", "phospholipase", "C", "inhibitor", ",", "nifedipine", ",", "or", "methoxyverapamil", "(", "C0006684#ent", "<e2>", "."], "h": {"id": "C1620102", "name": "C1620102#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [33, 34]}}
{"token": ["C0014059#ent", "<e1>", "ADEM", ")", "is", "an", "C0751873#ent", "<e2>", "the", "central", "nervous", "system", "is", "frequently", "preceded", "by", "an", "acute", "viral", "infection"], "h": {"id": "C0014059", "name": "C0014059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751873", "name": "C0751873#ent", "pos": [6, 7]}}
{"token": ["Mutations", "in", "the", "C1417768#ent", "<e1>", "the", "cause", "of", "the", "C3899989#ent", "<e2>", "CADASIL", "(", "cerebral", "autosomal", "arteriopathy", "with", "subcortical", "infarcts", "leukoencephalopathy", ")", "."], "h": {"id": "C1417768", "name": "C1417768#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3899989", "name": "C3899989#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "transfer", "of", "polarized", "T", "helper", "(", "C1420718#ent", "<e1>", ")", "1", "and", "Th2", "populations", "resulted", "in", "severe", "C0235394#ent", "<e2>", "and", "colitis", "in", "recipients", "colonized", "with", "OVA-expressing", "but", "not", "control", "E.", "coli"], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0235394", "name": "C0235394#ent", "pos": [19, 20]}}
{"token": ["Protein", "kinase", "D", "C1868682#ent", "<e1>", ")", ",", "also", "called", "protein", "kinase", "Cmu", "C0258823#ent", "<e2>", ")", ",", "is", "a", "serine/threonine", "kinase", "has", "unique", "enzymic", "and", "structural", "properties", "distinct", "from", "members", "of", "the", "PKC", "family", "of", "proteins", "."], "h": {"id": "C1868682", "name": "C1868682#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0258823", "name": "C0258823#ent", "pos": [12, 13]}}
{"token": ["Protein", "kinase", "D", "C1868682#ent", "<e1>", ")", ",", "also", "called", "C0258823#ent", "<e2>", "PKCmu", ")", ",", "is", "a", "serine/threonine", "kinase", "has", "unique", "enzymic", "and", "structural", "properties", "distinct", "from", "members", "of", "the", "PKC", "family", "of", "proteins", "."], "h": {"id": "C1868682", "name": "C1868682#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0258823", "name": "C0258823#ent", "pos": [9, 10]}}
{"token": ["Protein", "kinase", "D", "C1868682#ent", "<e1>", ",", "also", "known", "as", "C0258823#ent", "<e2>", ")", "is", "closely", "related", "to", "the", "protein", "kinase", "C", "superfamily", "is", "differentially", "regulated", "and", "has", "a", "distinct", "catalytic", "domain", "shares", "homology", "with", "Ca(2+)-dependent", "protein", "kinases"], "h": {"id": "C1868682", "name": "C1868682#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0258823", "name": "C0258823#ent", "pos": [9, 10]}}
{"token": ["Genetic", "deficiency", "C0015278#ent", "<e1>", "GAA", ")", "results", "in", "C0017921#ent", "<e2>"], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017921", "name": "C0017921#ent", "pos": [8, 9]}}
{"token": ["C0017922#ent", "<e1>", "usually", "characterized", "by", "hepatic", "symptoms", "growth", "failure", "C0026848#ent", "<e2>", "."], "h": {"id": "C0017922", "name": "C0017922#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [9, 10]}}
{"token": ["The", "C0042071#ent", "<e1>", "uPAR", ")", "is", "a", "receptor", "for", "both", "urokinase", "plasminogen", "activator", "C1335224#ent", "<e2>", ")", "and", "the", "adhesion", "protein", "vitronectin", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335224", "name": "C1335224#ent", "pos": [13, 14]}}
{"token": ["Its", "effects", "on", "two", "GPI-anchored", "proteins", "the", "C0042071#ent", "<e1>", "which", "binds", "urokinase-type", "plasminogen", "activator", "C1335224#ent", "<e2>", ")", "to", "cell", "surfaces", "and", "alkaline", "phosphatase", "were", "also", "studied", "using", "bovine", "chondrocytes", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335224", "name": "C1335224#ent", "pos": [14, 15]}}
{"token": ["A", "patient", "with", "C0038013#ent", "<e1>", "treatment", "with", "steroids", "was", "given", "C0031990#ent", "<e2>", "(", "Feldene", ")", "for", "relief", "of", "pain", "and", "disability", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [10, 11]}}
{"token": ["Twenty-five", "patients", "with", "C0038013#ent", "<e1>", "treatment", "with", "C0031990#ent", "<e2>", "during", "12", "weeks", "in", "an", "open", ",", "non-comparative", "trial", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [7, 8]}}
{"token": ["According", "to", "the", "ANRS", "2006", "C1539614#ent", "<e1>", "list", "and", "algorithm", ",", "none", "of", "the", "40", "C1875400#ent", "<e2>", "was", "found", "to", "be", "resistant", "to", "any", "protease", "or", "reverse", "transcriptase", "inhibitors"], "h": {"id": "C1539614", "name": "C1539614#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [15, 16]}}
{"token": ["The", "controlled", "release", "encapsulated", "redox", "species", "the", "surface-bound", "vesicles", "is", "mediated", "by", "the", "C1418887#ent", "<e1>", "functionality", "of", "C3539661#ent", "<e2>", ",", "allowing", "amperometric", "detection", "of", "the", "targeted", "toxin", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539661", "name": "C3539661#ent", "pos": [17, 18]}}
{"token": ["In", "our", "models", ",", "C0000970#ent", "<e1>", "appears", "to", "increase", "C1142644#ent", "<e2>", "activity", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [9, 10]}}
{"token": ["The", "addition", "of", "caffeine", "disrupted", "the", "ability", "of", "C0000970#ent", "<e1>", "to", "coordinate", "with", "the", "heme", "iron", "C1142644#ent", "<e2>", "enhanced", "the", "rate", "of", "oxidation", "to", "its", "toxic", "metabolite"], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [8, 9]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [16, 17]}}
{"token": ["When", "C0000970#ent", "<e1>", "was", "incubated", "with", "C1142644#ent", "<e2>", "the", "acetamido", "group", "of", "C0000970#ent", "<e1>", "was", "found", "to", "be", "closest", "to", "the", "heme", "iron", "consistent", "with", "amide", "group", "C0000970#ent", "<e1>", "weakly", "associating", "with", "the", "heme", "iron"], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [1, 2]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}}
{"token": ["D2", "and", "D3", "receptors", "also", "found", "to", "interact", "with", "the", "highly", "conserved", "C1416810#ent", "<e1>", "4.1R", ",", "4.1", "G", ",", "and", "C1414425#ent", "<e2>", "."], "h": {"id": "C1416810", "name": "C1416810#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414425", "name": "C1414425#ent", "pos": [20, 21]}}
{"token": ["A", "proteolytic", "cascade", "the", "C0028978#ent", "<e1>", "signal", "by", "regulated", "proteolysis", "of", "C1705701#ent", "<e2>", ",", "a", "membrane-spanning", "anti-sigma", "factor", "whose", "cytoplasmic", "domain", "inhibits", "sigma(E)-dependent", "transcription", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705701", "name": "C1705701#ent", "pos": [11, 12]}}
{"token": ["Hemorheological", "changes", "to", "a", "certain", "extend", "may", "occur", "not", "only", "in", "C0007222#ent", "<e1>", "but", "also", "in", "senile", "dementia", "C1843013#ent", "<e2>", "SDAT", ")", "and", "certain", "cases", "of", "Parkinson's", "disease"], "h": {"id": "C0007222", "name": "C0007222#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1843013", "name": "C1843013#ent", "pos": [18, 19]}}
{"token": ["The", "contrasting", "functions", "of", "C0812201#ent", "<e1>", "and", "Fli1", "in", "regulation", "of", "the", "CCN2", "C0017337#ent", "<e2>", "were", "confirmed", "by", "suppressing", "their", "endogenous", "levels", "using", "adenoviral", "vectors", "expressing", "specific", "small", "interfering", "RNAs", "."], "h": {"id": "C0812201", "name": "C0812201#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["C0812201#ent", "<e1>", "transcription", "factors", "activate", "or", "repress", "the", "expression", "of", "C0017337#ent", "<e2>", "that", "are", "involved", "in", "various", "biological", "processes", "including", "cellular", "proliferation", "differentiation", ",", "development", ",", "transformation", "and", "apoptosis", "."], "h": {"id": "C0812201", "name": "C0812201#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["The", "transcription", "factor", "C0812201#ent", "<e1>", "regulates", "the", "expression", "of", "several", "C0017337#ent", "<e2>", "involved", "in", "extracellular", "matrix", "remodeling", "that", "may", "account", "for", "its", "association", "with", "lymph", "node", "distant", "organ", "metastasis"], "h": {"id": "C0812201", "name": "C0812201#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["In", "vitro", "C0812201#ent", "<e1>", "involved", "in", "the", "transcriptional", "induction", "C0017337#ent", "<e2>", "such", "as", "stromelysin", "1", "collagenase", "1", "urokinase", "type", "plasminogen", "activator", "which", "are", "proteases", "responsible", "for", "extracellular", "matrix", "degradation", "."], "h": {"id": "C0812201", "name": "C0812201#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["It", "is", "proposed", "that", "lipids", ",", "particularly", "acidic", "ones", "act", "on", "solubilized", "glucocerebrosidase", "to", "produce", "an", "C0014442#ent", "<e1>", "conformation", "which", "allows", "binding", "and", "stimulation", "by", "C0141547#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0141547", "name": "C0141547#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "mutant", "bacteriophages", "C0025297#ent", "<e1>", "causing", "bacteria", "bind", "to", "and", "detect", "the", "molecularly", "mimicked", "C0071677#ent", "<e2>", "the", "neural", "cell", "adhesion", "molecule", "host", "tissues"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0071677", "name": "C0071677#ent", "pos": [15, 16]}}
{"token": ["Arsenic", "trioxide", "to", "increased", "cell", "surface", "expression", "of", "C1705132#ent", "<e1>", "(", "death", "receptor", "5", ",", "inhibition", "of", "the", "serine/threonine", "kinase", "C0164786#ent", "<e2>", "and", "downregulation", "of", "the", "short", "isoform", "of", "FLIP", "(", "FLICE-inhibitory", "protein", "FLIPS", ")", "."], "h": {"id": "C1705132", "name": "C1705132#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [20, 21]}}
{"token": ["The", "incidence", "of", "confirmed", "progression", "of", "C0018802#ent", "<e1>", "significantly", "lower", "in", "the", "C0717550#ent", "<e2>", "group(7.4", "%", ")", "than", "in", "the", "placebo", "group(22.2", "%", ")", ",", "with", "risk", "reduction", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0717550", "name": "C0717550#ent", "pos": [12, 13]}}
{"token": ["In", "C1956346#ent", "<e1>", "the", "protective", "effects", "mainly", "C0003438#ent", "<e2>", ",", "antioxidant", ",", "anti-ischaemic", "and", "vasorelaxant", "properties", "of", "flavonoids", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [7, 8]}}
{"token": ["Daily", "use", "of", "C0242896#ent", "<e1>", "and", "benzodiazepines", "were", "both", "significantly", "greater", "for", "the", "C0016368#ent", "<e2>", "group", "(", "P=.003", "and.04", ",", "respectively", ")", "."], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [13, 14]}}
{"token": ["It", "is", "suggested", "that", "the", "C1843785#ent", "<e1>", "and", "parE", "genes", "for", "the", "subunits", "of", "a", "new", "C1336767#ent", "<e2>", ",", "named", "topo", "IV"], "h": {"id": "C1843785", "name": "C1843785#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [16, 17]}}
{"token": ["The", "frequency", "of", "C0019163#ent", "<e1>", "reactivation", "and", "the", "development", "of", "C0019159#ent", "<e2>", "OLT", "were", "associated", "with", "preoperative", "presence", "of", "C0019163#ent", "<e1>", ",", "as", "determined", "by", "the", "molecular", "hybridization", "assay"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [3, 4]}}
{"token": ["An", "economical", "phase-transfer", "method", "is", "used", "to", "prepare", "10-arylaminoartemisinins", "from", "DHA", "and", "arylamines", ",", "and", "C0052429#ent", "<e1>", ",", "arteether", ",", "and", "artelinate", "from", "the", "corresponding", "C0001975#ent", "<e2>", "."], "h": {"id": "C0052429", "name": "C0052429#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [25, 26]}}
{"token": ["They", "also", "suggest", "a", "specific", "role", "for", "C1418926#ent", "<e1>", "determining", "the", "C1539479#ent", "<e2>", "of", "different", "myoblasts", "during", "muscle", "histogenesis", "."], "h": {"id": "C1418926", "name": "C1418926#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [11, 12]}}
{"token": ["No", "patients", "had", "a", "psychotic", "disease", "C0014130#ent", "<e1>", "other", "than", "C0020503#ent", "<e2>"], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0020503", "name": "C0020503#ent", "pos": [10, 11]}}
{"token": ["The", "C0034861#ent", "<e1>", "AtsPLA(2)-gamma", "showed", "maximal", "enzyme", "activity", "pH", "8.0", ",", "and", "required", "C0001477#ent", "<e2>", "activity", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [13, 14]}}
{"token": ["These", "C1417679#ent", "<e1>", "cooperated", "with", "C1840524#ent", "<e2>", "in", "transforming", "NIH", "3T3", "cells"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1840524", "name": "C1840524#ent", "pos": [5, 6]}}
{"token": ["Organisms", "using", "glycolysis", "for", "carbon", "assimilation", "have", "C0061415#ent", "<e1>", "fructose-1,6-bis-phosphate", "as", "the", "major", "C1422492#ent", "<e2>", "."], "h": {"id": "C0061415", "name": "C0061415#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [13, 14]}}
{"token": ["Randomized", ",", "long-term", "studies", "are", "needed", "to", "assess", "the", "efficacy", "and", "possible", "role", "of", "C0342788#ent", "<e1>", "in", "the", "future", "management", "of", "C0018802#ent", "<e2>"], "h": {"id": "C0342788", "name": "C0342788#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["In", "the", "case", "of", "amiodarone", ",", "clinical", "trial", "data", "to", "date", "suggest", "that", "it", "should", "not", "be", "used", "for", "primary", "prevention", "C0342788#ent", "<e1>", "or", "to", "prolong", "survival", "in", "patients", "with", "C0018802#ent", "<e2>", "secondary", "to", "coronary", "artery", "disease"], "h": {"id": "C0342788", "name": "C0342788#ent", "pos": [21, 22]}, "relation": "has_manifestation", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [30, 31]}}
{"token": ["This", "paper", "concerns", "the", "specificity", "of", "C0028005#ent", "<e1>", ",", "a", "calcium", "antagonist", "the", "C0012315#ent", "<e2>", "is", "used", "in", "the", "treatment", "of", "cardiovascular", "disorders"], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [6, 7]}, "relation": "has_structural_class", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [13, 14]}}
{"token": ["The", "antihypertensive", "action", "OPC-13340", ",", "a", "new", "dihydropyridine", ",", "was", "studied", "in", "rats", "and", "compared", "with", "the", "action", "of", "C0028005#ent", "<e1>", "and", "other", "C0012315#ent", "<e2>", "."], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [19, 20]}, "relation": "has_structural_class", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [23, 24]}}
{"token": ["C0028005#ent", "<e1>", "is", "a", "C0012315#ent", "<e2>", "enhanced", "selectivity", "for", "vascular", "smooth", "muscle"], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [4, 5]}}
{"token": ["C0028005#ent", "<e1>", "in", "dogs", "and", "suggest", "a", "functional", "interaction", "between", "C0012315#ent", "<e2>", "cardiovascular", "cholinergic", "mechanisms", "in", "the", "brain", "."], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [10, 11]}}
{"token": ["This", "trial", "was", "performed", "to", "determine", "the", "safe", "and", "effective", "dosage", "range", "of", "once", "daily", "diltiazem", "(", "C0282138#ent", "<e1>", "capsules", "for", "treatment", "of", "C0155583#ent", "<e2>"], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [23, 24]}}
{"token": ["We", "concluded", "the", "oral", "calcium", "antagonist", "C0282138#ent", "<e1>", ",", "is", "effective", "in", "patients", "with", "C0155583#ent", "<e2>", "providing", "significant", "blood", "pressure", "and", "symptomatic", "benefit", "with", "long-term", "treatment", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [14, 15]}}
{"token": ["Studies", "suggest", "a", "beneficial", "role", "of", "C0282138#ent", "<e1>", "in", "the", "treatment", "of", "C0155583#ent", "<e2>"], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [12, 13]}}
{"token": ["This", "study", "assessed", "once-daily", "(", "OD", ")", ",", "sustained-release", "(", "SR", ")", "C0282138#ent", "<e1>", "alone", "and", "in", "combination", "with", "ramipril", "in", "C0155583#ent", "<e2>"], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [21, 22]}}
{"token": ["C0032285#ent", "<e1>", "an", "important", "component", "of", "a", "number", "of", "C0024115#ent", "<e2>", "including", "acute", "respiratory", "distress", "syndrome", "ARDS", ")", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [9, 10]}}
{"token": ["Tests", "for", "ferritin", "and", "lactoferrin", "proved", "useful", "in", "evaluation", "of", "C0032285#ent", "<e1>", ",", "early", "detection", "pulmonary", "and", "intrapleural", "supputation", "differential", "diagnosis", "C0024115#ent", "<e2>", "lung", "cancer"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [21, 22]}}
{"token": ["Since", "first", "described", "in", "1922", ",", "C0038325#ent", "<e1>", "been", "associated", "frequently", "with", "C1535939#ent", "<e2>", "of", "many", "etiologies", "."], "h": {"id": "C0038325", "name": "C0038325#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [12, 13]}}
{"token": ["M.", "pneumoniae", "infection", "be", "considered", "in", "cases", "of", "C0038325#ent", "<e1>", "adults", "with", "C1535939#ent", "<e2>", "."], "h": {"id": "C0038325", "name": "C0038325#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [12, 13]}}
{"token": ["C0244656#ent", "<e1>", "is", "indicated", "for", "the", "treatment", "of", "generalized", "convulsions", "C0036572#ent", "<e2>", "occurring", "during", "neurosurgery", "."], "h": {"id": "C0244656", "name": "C0244656#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}}
{"token": ["Our", "study", "suggests", "that", "DRD1", "and", "C1333253#ent", "<e1>", "variants", "are", "not", "liability", "factors", "for", "C0686347#ent", "<e2>"], "h": {"id": "C1333253", "name": "C1333253#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0686347", "name": "C0686347#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "anti-ENA", "antibodies", "C0024141#ent", "<e1>", "patients", "are", "associated", "with", "low", "prevalence", "of", "C0027697#ent", "<e2>", "and", "a", "clinical", "and", "laboratory", "profile", "to", "that", "of", "the", "MCTD", "syndrome", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0027697", "name": "C0027697#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "show", "that", "C1427877#ent", "<e1>", "is", "a", "novel", "receptor", "for", "C1416969#ent", "<e2>", "and", "acts", "selectively", "to", "mediate", "C1416969#ent", "<e2>", "inhibitory", "responses", "."], "h": {"id": "C1427877", "name": "C1427877#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416969", "name": "C1416969#ent", "pos": [11, 12]}}
{"token": ["Forced", "expression", "of", "C1427877#ent", "<e1>", "is", "sufficient", "to", "impart", "C1416969#ent", "<e2>", "inhibition", "to", "neonatal", "sensory", "neurons", "."], "h": {"id": "C1427877", "name": "C1427877#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416969", "name": "C1416969#ent", "pos": [9, 10]}}
{"token": ["Structural", "studies", "revealed", "that", "the", "C1427877#ent", "<e1>", "leucine-rich", "repeat", "cluster", "the", "C1427877#ent", "<e1>", "\"", "unique", "\"", "domain", "are", "necessary", "for", "high-affinity", "C1416969#ent", "<e1>", "binding", "."], "h": {"id": "C1427877", "name": "C1427877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416969", "name": "C1416969#ent", "pos": [21, 22]}}
{"token": ["Following", "4-DAMP", "mustard", "treatment", ",", "oxotremorine-M", "elicited", "a", "contractile", "response", "C2987364#ent", "<e1>", "urinary", "bladder", "the", "presence", "of", "KCl", "and", "C0022245#ent", "<e2>", "or", "forskolin", ",", "and", "this", "response", "was", "diminished", "in", "M2", "KO", "mice", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [19, 20]}}
{"token": ["Treatment", "of", "C2987364#ent", "<e1>", "and", "mutant", "receptors", "0.3", "nm", "C0022245#ent", "<e2>", "for", "5", "min", "induced", "approximately", "2-fold", "increases", "in", "the", "EC(50", ")", "for", "agonist", "activation", "of", "adenylyl", "cyclase", "consistent", "with", "protein", "kinase", "A", "PKA", ")", "site-mediated", "desensitization"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [9, 10]}}
{"token": ["In", "Wistar", "rats", "we", "found", "that", "some", "C0010207#ent", "<e1>", "were", "poor", "substrates", "of", "UDPGT", "(", "C3537450#ent", "<e2>", ")", "and", "that", "twenty", "monoterpenoid", "alcohol", "activities", "typical", "phenobarbital-inducible", "behavior", "."], "h": {"id": "C0010207", "name": "C0010207#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537450", "name": "C3537450#ent", "pos": [15, 16]}}
{"token": ["The", "present", "family", "emphasises", "that", "C0231528#ent", "<e1>", "is", "a", "prominent", "symptom", "in", "C2931689#ent", "<e2>", "and", "the", "clinical", "differences", "be", "explained", "by", "genetic", "heterogeneity"], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C2931689", "name": "C2931689#ent", "pos": [12, 13]}}
{"token": ["RecQ-like", "C0114667#ent", "<e1>", "pair", "with", "C0114645#ent", "<e2>", "enzymes", "to", "function", "in", "the", "maintenance", "of", "genomic", "integrity", "many", "organisms", "."], "h": {"id": "C0114667", "name": "C0114667#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0114645", "name": "C0114645#ent", "pos": [5, 6]}}
{"token": ["The", "effect", "of", "C0033036#ent", "<e1>", "left", "ventricular", "function", "six", "patients", "with", "varying", "degrees", "of", "C0026269#ent", "<e2>", "determined", "by", "utilizing", "the", "pressure", "gradient", "technique", "measure", "instantaneous", "aortic", "blood", "flow", "and", "pressure", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [14, 15]}}
{"token": ["Late", "diastolic", "anterior", "movement", "of", "the", "posterior", "mitral", "valve", "leaflet", "C0033036#ent", "<e1>", "diagnostic", "of", "C0026269#ent", "<e2>"], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [14, 15]}}
{"token": ["CM", "are", "independently", "associated", "with", "blood", "pressure", "HbA1c", "as", "well", "as", "with", "C0333559#ent", "<e1>", "WMH", "volume", "in", "C3813553#ent", "<e2>", "."], "h": {"id": "C0333559", "name": "C0333559#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3813553", "name": "C3813553#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "C0038766#ent", "<e1>", "and", "a", "C3537187#ent", "<e2>", "on", "membrane-bound", "low", "cyclic", "AMP", "phosphodiesterase", "and", "lipolysis", "were", "examined", "in", "rat", "fat", "cells"], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537187", "name": "C3537187#ent", "pos": [7, 8]}}
{"token": ["The", "combination", "of", "a", "C0038766#ent", "<e1>", "with", "a", "C3537187#ent", "<e2>", "improves", "the", "pancreatic", "beta-cell", "insulin", "secretion", "the", "insulin", "utilization", "in", "peripheral", "tissues", "NIDDM", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537187", "name": "C3537187#ent", "pos": [8, 9]}}
{"token": ["Although", "VCAM-1", "is", "also", "induced", "by", "the", "C1334112#ent", "<e1>", "IL-1", "beta", ",", "activation", "of", "the", "dsRNA-activated", "protein", "kinase", "C0058980#ent", "<e2>", ")", "occurs", "only", "in", "response", "to", "incubation", "with", "dsRNA", "but", "not", "with", "IL-1", "beta"], "h": {"id": "C1334112", "name": "C1334112#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [18, 19]}}
{"token": ["Although", "VCAM-1", "is", "also", "induced", "by", "the", "C1334112#ent", "<e1>", "IL-1", "beta", ",", "activation", "of", "the", "C0058980#ent", "<e2>", "PKR", ")", "occurs", "only", "in", "response", "to", "incubation", "with", "dsRNA", "but", "not", "with", "IL-1", "beta"], "h": {"id": "C1334112", "name": "C1334112#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [15, 16]}}
{"token": ["Besides", "C1415856#ent", "<e1>", ",", "also", "the", "Id1", "and", "Id2", "C0017337#ent", "<e2>", "were", "activated", "by", "BMP4", "in", "both", "ES", "cells", "a", "range", "of", "different", "cell", "lines"], "h": {"id": "C1415856", "name": "C1415856#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["We", "recently", "reported", "that", "the", "proangiogenic", "pituitary", "tumor", "transforming", "gene", "PTTG", ")", "stimulates", "VEGF", "and", "up-regulates", "inhibitor", "of", "DNA", "binding-3", "C1415856#ent", "<e1>", ")", ",", "an", "important", "C0017337#ent", "<e2>", "in", "VEGF-dependent", "angiogenesis", "."], "h": {"id": "C1415856", "name": "C1415856#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [26, 27]}}
{"token": ["In", "the", "human", "umbilical", "vein", "contraction", "assay", "MEN", "11270", ",", "shifted", "the", "concentration-response", "curve", "C1537501#ent", "<e1>", "to", "the", "right", "in", "a", "concentration-dependent", "manner", "(", "C1839576#ent", "<e2>", "8.14", "+", "/-", "0.22", ",", "n", "=", "7", ")", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [24, 25]}}
{"token": ["The", "antagonism", "of", "the", "constrictor", "responses", "C1537501#ent", "<e1>", "by", "HOE-140", "was", "found", "to", "be", "competitive", "(", "C1839576#ent", "<e2>", "=", "7.5", ")", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [16, 17]}}
{"token": ["The", "B2", "receptor", "antagonist", "Hoe", "140", "(", "0.1", ",", "1", "and", "10", "microM", ")", ",", "produced", "a", "parallel", "shift", "to", "the", "right", "of", "the", "concentration-response", "curve", "C1537501#ent", "<e1>", "with", "a", "C1839576#ent", "<e2>", "of", "7.75", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [30, 31]}}
{"token": ["Phosphorylation", "of", "phosphatidylinositol", "(", "PtdIns", ")", "by", "C2713509#ent", "<e1>", "essential", "for", "C3537312#ent", "<e2>", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537312", "name": "C3537312#ent", "pos": [11, 12]}}
{"token": ["Vps34", ",", "the", "sole", "C2713509#ent", "<e1>", "yeast", ",", "is", "essential", "for", "C3537312#ent", "<e2>", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537312", "name": "C3537312#ent", "pos": [11, 12]}}
{"token": ["Thirty-four", "isolates", "were", "resistant", "to", "at", "least", "one", "of", "the", "antibiotics", "tested", "and", "62", "%", "of", "these", "isolates", "possessed", "C0033993#ent", "<e1>", "plasmids", "belonging", "to", "C0597199#ent", "<e2>"], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0597199", "name": "C0597199#ent", "pos": [24, 25]}}
{"token": ["We", "evaluated", "the", "potential", "for", "daily", "low-dose", "C0004609#ent", "<e1>", "administered", "over", "several", "weeks", "to", "increase", "plasma", "C1334089#ent", "<e2>", "levels", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [16, 17]}}
{"token": ["The", "present", "study", "investigated", "the", "effect", "of", "chronic", "administration", "C0004609#ent", "<e1>", "on", "the", "provocative", "testing", "hGH", "secretion", "and", "plasma", "C1334089#ent", "<e2>", "levels", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [19, 20]}}
{"token": ["Inherited", "C0268487#ent", "<e1>", "of", "adenosine", "deaminase", "C0034135#ent", "<e2>", "been", "found", "to", "be", "associated", "with", "immunodeficiency", "syndromes", "are", "characterized", "by", "C0268487#ent", "<e1>", "of", "mature", "peripheral", "lymphocytes"], "h": {"id": "C0034135", "name": "C0034135#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [1, 2]}}
{"token": ["Analogues", "that", "are", "poor", "substrates", "for", "adenosine", "deaminase", "C0034135#ent", "<e1>", "mimic", "immunodeficiencies", "associated", "with", "enzyme", "C0268487#ent", "<e2>", ",", "and", "their", "activities", "may", "be", "directed", "toward", "selected", "lymphocyte", "subpopulations", "."], "h": {"id": "C0034135", "name": "C0034135#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [15, 16]}}
{"token": ["The", "purine", "metabolic", "enzymes", "adenosine", "deaminase", "(", "ADA", ")", "and", "C0034135#ent", "<e1>", "PNP", ")", "are", "important", "in", "lymphocyte", "differentiation", "and", "C0268487#ent", "<e2>", "either", "enzyme", "have", "been", "associated", "with", "hereditary", "immunodeficiency", "states"], "h": {"id": "C0034135", "name": "C0034135#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [20, 21]}}
{"token": ["C0016277#ent", "<e1>", "is", "a", "novel", "C0003308#ent", "<e2>", "excellent", "activities", "against", "a", "broad", "range", "of", "medically", "important", "fungi", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [5, 6]}}
{"token": ["Administration", "of", "C0017628#ent", "<e1>", "to", "diabetic", "rats", "reversed", "the", "diabetes-induced", "changes", ",", "suggesting", "that", "C0017628#ent", "<e1>", "may", "directly", "increase", "liver", "C0038838#ent", "<e1>", "enzyme", "activity", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [20, 21]}}
{"token": ["The", "results", "of", "this", "study", "demonstrate", "that", "the", "sulfonylurea", ",", "C0017628#ent", "<e1>", ",", "is", "capable", "of", "exerting", "direct", "insulin-like", "effects", "muscle", "C0038838#ent", "<e2>", "activity", "in", "vivo"], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [21, 22]}}
{"token": ["When", "compared", "with", "normal", "brain", "tissue", "AT/RT", "cell", "lines", "C3889446#ent", "<e1>", "the", "IR", "(", "insulin", "receptor", "and", "the", "C1334088#ent", "<e2>", "(", "insulin-like", "growth", "factor-I", "receptor", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334088", "name": "C1334088#ent", "pos": [18, 19]}}
{"token": ["Here", "we", "show", "that", "the", "C0769198#ent", "<e1>", "CARM1", ")", "is", "required", "for", "cAMP-mediated", "activation", "rate-limiting", "C0031644#ent", "<e2>", "PEPCK", ";", "EC", "4.1.1.32", "and", "glucose-6-phosphatase", "genes"], "h": {"id": "C0769198", "name": "C0769198#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [15, 16]}}
{"token": ["Genitourinary", "tract", "involvement", "with", "genital", "apthous", "ulcers", ",", "epididymitis", ",", "C0311389#ent", "<e1>", "and", "recurrent", "C0600041#ent", "<e2>", "is", "encountered", "commonly", "."], "h": {"id": "C0311389", "name": "C0311389#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0600041", "name": "C0600041#ent", "pos": [14, 15]}}
{"token": ["Laser", "therapy", "found", "particularly", "effective", "in", "the", "treatment", "of", "residual", "C0311389#ent", "<e1>", "and", "valuable", "in", "multiple-modality", "treatment", "of", "urethrogenic", "epididymitis", "C0600041#ent", "<e2>", ",", "and", "prostatitis", "."], "h": {"id": "C0311389", "name": "C0311389#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0600041", "name": "C0600041#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "treatment", "with", "C1705323#ent", "<e1>", "siRNAs", "downregulated", "the", "expression", "of", "C1705323#ent", "<e1>", "mRNA", ";", "furthermore", ",", "the", "siCOX-2-mediated", "suppression", "of", "C1705323#ent", "<e1>", "also", "resulted", "in", "suppression", "of", "C0003805#ent", "<e1>", "mRNA", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [28, 29]}}
{"token": ["These", "results", "suggested", "the", "possibility", "that", "C1705323#ent", "<e1>", "was", "the", "functional", "intermediate", "linking", "HER-2/neu", "and", "C0003805#ent", "<e2>", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [15, 16]}}
{"token": ["Inhibition", "by", "sphingosine", "was", "competitive", "with", "respect", "to", "C0031607#ent", "<e1>", "phosphatidylinositol", ",", "or", "phosphatidylserine", ",", "suggesting", "that", "anionic", "phospholipids", "activate", "C1417133#ent", "<e2>", "at", "a", "specific", "site", "that", "is", "competitively", "blocked", "by", "sphingolipids", "."], "h": {"id": "C0031607", "name": "C0031607#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417133", "name": "C1417133#ent", "pos": [20, 21]}}
{"token": ["BACKGROUND", "A", "few", "recent", "studies", "dampen", "the", "euphoric", "reports", "the", "value", "of", "percutaneous", "endoscopic", "lumbar", "discectomy", "C4014700#ent", "<e1>", ")", "in", "the", "treatment", "of", "C0158252#ent", "<e2>"], "h": {"id": "C4014700", "name": "C4014700#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0158252", "name": "C0158252#ent", "pos": [23, 24]}}
{"token": ["This", "interaction", "was", "mapped", "to", "the", "middle", "one-third", "(", "C3539947#ent", "<e1>", "-", "301", ")", "of", "NS5A", "and", "the", "TRAF", "domain", "C1366777#ent", "<e2>", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366777", "name": "C1366777#ent", "pos": [20, 21]}}
{"token": ["C0242520#ent", "<e1>", "Graves'", "disease", "highly", "positive", "while", "adenoma", ",", "thyroid", "cancer", "SLE", ",", "and", "C0003873#ent", "<e2>", "were", "low", "in", "their", "positivity", "."], "h": {"id": "C0242520", "name": "C0242520#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["C0242520#ent", "<e1>", "Graves'", "disease", "highly", "positive", "while", "thyroid", "cancer", "adenoma", ",", "SLE", ",", "and", "C0003873#ent", "<e2>", "were", "low", "in", "their", "positivity", "."], "h": {"id": "C0242520", "name": "C0242520#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "C1334905#ent", "<e1>", "secretion", "was", "completely", "inhibited", "by", "the", "combination", "of", "C0298346#ent", "<e2>", "and", "SP600125", "(", "JNK", "inhibitor", ")", "."], "h": {"id": "C1334905", "name": "C1334905#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0298346", "name": "C0298346#ent", "pos": [14, 15]}}
{"token": ["These", "results", "demonstrate", "that", "C0432255#ent", "<e1>", "suppresses", "inducible", "P4502E1", "expression", "more", "significantly", "than", "C0907533#ent", "<e2>", "expression", ",", "and", "that", "C0432255#ent", "<e1>", "induces", "GST", "and", "mEH", "expression", "to", "a", "certain", "extent", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0432255", "name": "C0432255#ent", "pos": [4, 5]}}
{"token": ["Fetal", "NPHS1", "kidneys", "with", "Fin-major/Fin-major", "genotype", "did", "not", "express", "nephrin", ",", "whereas", "the", "expression", "of", "C1420744#ent", "<e1>", "and", "P-cadherin", "was", "comparable", "to", "that", "of", "C0152169#ent", "<e2>"], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0152169", "name": "C0152169#ent", "pos": [24, 25]}}
{"token": ["For3", "bound", "to", "active", "forms", "both", "Rho3", "and", "C1366537#ent", "<e1>", "but", "not", "to", "that", "of", "C0538674#ent", "<e2>", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0538674", "name": "C0538674#ent", "pos": [15, 16]}}
{"token": ["Several", "key", "proteins", "(", "e.g.", "C1366537#ent", "<e1>", ",", "septins", ",", "Bni1", "formin", ",", "C0538674#ent", "<e2>", "and", "Rho3", ")", "play", "common", "roles", "in", "polarity", "establishment", "and", "early", "polarity", "maintenance", "in", "both", "processes", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0538674", "name": "C0538674#ent", "pos": [13, 14]}}
{"token": ["Further", "investigation", "suggested", "that", "insulin", "increased", "the", "amount", "of", "MEK", "bound", "to", "C1825781#ent", "<e1>", "(", "C1334325#ent", "<e2>", "Ras", ")", "and", "restored", "GH-induced", "tyrosine", "phosphorylation", "C1825781#ent", "<e1>", "."], "h": {"id": "C1334325", "name": "C1334325#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1825781", "name": "C1825781#ent", "pos": [12, 13]}}
{"token": ["Inhibition", "of", "C1335892#ent", "<e1>", "using", "siRNA", "or", "C1176007#ent", "<e2>", "down-regulated", "the", "iNOS", "expression", "and", "reduced", "NO", "production", "."], "h": {"id": "C1335892", "name": "C1335892#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1176007", "name": "C1176007#ent", "pos": [7, 8]}}
{"token": ["Finally", ",", "C1335892#ent", "<e1>", "inhibition", "by", "C1176007#ent", "<e2>", "or", "by", "siRNA", "plasmids", "in", "a", "potent", "inhibition", "of", "mTOR", "activity", "in", "FL", "cells", "as", "well", "as", "in", "mantle", "cell", "lymphoma", "Burkitt", "lymphoma", "and", "diffuse", "large", "B-cell", "lymphoma"], "h": {"id": "C1335892", "name": "C1335892#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1176007", "name": "C1176007#ent", "pos": [6, 7]}}
{"token": ["Inhibiting", "C1335892#ent", "<e1>", "activation", "with", "C1176007#ent", "<e2>", "results", "in", "the", "inhibition", "of", "PIP(3", ")", "production", "and", "aggregation", "."], "h": {"id": "C1335892", "name": "C1335892#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1176007", "name": "C1176007#ent", "pos": [5, 6]}}
{"token": ["Specifically", ",", "high", "levels", "of", "CamKIIalpha", "C1511573#ent", "<e1>", "were", "detected", "in", "hippocampus", ",", "cortex", ",", "and", "C0002707#ent", "<e2>", ",", "and", "lower", "levels", "detected", "in", "striatum", ",", "thalamus", ",", "and", "hypothalamus", "."], "h": {"id": "C1511573", "name": "C1511573#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002707", "name": "C0002707#ent", "pos": [16, 17]}}
{"token": ["Consistently", "with", "the", "identification", "of", "Mpr1p", "with", "a", "C1419015#ent", "<e1>", "the", "mutation", "is", "complemented", "by", "the", "human", "C1424617#ent", "<e2>", "proteasomal", "gene"], "h": {"id": "C1419015", "name": "C1419015#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1424617", "name": "C1424617#ent", "pos": [17, 18]}}
{"token": ["C0085228#ent", "<e1>", "was", "shown", "to", "be", "a", "safe", "C1254351#ent", "<e2>", "and", "no", "unexpected", "or", "previously", "undetected", "drug-related", "events", "were", "encountered", "."], "h": {"id": "C0085228", "name": "C0085228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "C1522428#ent", "<e1>", "a", "molecular", "weight", "-", "30,000", ",", "while", "the", "C1420642#ent", "<e2>", "a", "molecular", "weight", "50,000", "-", "70,000", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420642", "name": "C1420642#ent", "pos": [13, 14]}}
{"token": ["C1417500#ent", "<e1>", "+", "has", "been", "linked", "to", "a", "naturally", "occurring", "C0006684#ent", "<e2>"], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [10, 11]}}
{"token": ["C1565489#ent", "<e1>", "lead", "to", "C0020503#ent", "<e2>", "the", "elderly", ",", "the", "condition", "that", "facilitates", "bone", "loss"], "h": {"id": "C1565489", "name": "C1565489#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020503", "name": "C0020503#ent", "pos": [4, 5]}}
{"token": ["The", "presentation", "of", "those", "in", "the", "1st", "quintile", "was", "consistent", "with", "C1565489#ent", "<e1>", "deficiency", ",", "with", "impaired", "calcium", "absorption", "C0020503#ent", "<e2>", "and", "stimulated", "bone", "turnover", "high", "normal", "urinary", "DPD", ")", "."], "h": {"id": "C1565489", "name": "C1565489#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020503", "name": "C0020503#ent", "pos": [19, 20]}}
{"token": ["Five", "C0041948#ent", "<e1>", "patients", "on", "RDT", ",", "with", "severe", "C0683382#ent", "<e2>", "resistant", "to", "medical", "therapy", "treated", "with", "oral", "angiotensin", "converting", "enzyme", "inhibitor", "captopril", "for", "3", "to", "6", "months", "and", "the", "effects", "of", "drug", "were", "studied", "."], "h": {"id": "C0041948", "name": "C0041948#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0683382", "name": "C0683382#ent", "pos": [9, 10]}}
{"token": ["We", "simulated", "ischemic", "conditions", "in", "cultures", "of", "purified", "C0128101#ent", "<e1>", "neurons", "and", "found", "that", "low", "doses", "of", "the", "antihypertensive", "drug", "C0282138#ent", "<e2>", "protected", "against", "excitotoxic", "neuronal", "damage", "in", "vitro"], "h": {"id": "C0128101", "name": "C0128101#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [20, 21]}}
{"token": ["At", "the", "cellular", "level", "C1705350#ent", "<e1>", "inhibition", "increased", "C1413132#ent", "<e2>", "and", "induced", "neuronal", "apoptosis"], "h": {"id": "C1705350", "name": "C1705350#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413132", "name": "C1413132#ent", "pos": [8, 9]}}
{"token": ["4-Aminobutyrate", "aminotransferase", "EC", "2.6.1.19", ",", "4", "aminobutyrate:2-oxoglutarate", "C0002594#ent", "<e1>", ")", "is", "cleaved", "by", "C0041236#ent", "<e2>", ",", "yielding", "an", "enzymatically", "active", "species", "which", "can", "be", "separated", "from", "the", "split", "peptides", "by", "gel", "filtration"], "h": {"id": "C0002594", "name": "C0002594#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [13, 14]}}
{"token": ["In", "the", "case", "of", "C0003873#ent", "<e1>", "the", "association", "with", "the", "C1419102#ent", "<e2>", "the", "most", "replicated", "after", "association", "with", "HLA", "genes"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1419102", "name": "C1419102#ent", "pos": [10, 11]}}
{"token": ["In", "yeast", "lacking", "C0048865#ent", "<e1>", "along", "with", "both", "AICAR", "C1530787#ent", "<e2>", ",", "5-CHO-THF", "was", "elevated", "12-fold", "over", "wild", "type"], "h": {"id": "C0048865", "name": "C0048865#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1530787", "name": "C1530787#ent", "pos": [9, 10]}}
{"token": ["Several", "studies", "demonstrated", "that", "previous", "heat", "shock", "treatment", "caused", "expression", "of", "heat", "shock", "proteins", "C0085292#ent", "<e1>", ")", "and", "reduced", "organ", "dysfunction", "mortality", "in", "experimentally", "induced", "severe", "C0243026#ent", "<e2>", "."], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [26, 27]}}
{"token": ["FK506", "also", "blocked", "the", "decrease", "of", "C1332824#ent", "<e1>", "expression", "caused", "by", "C0022020#ent", "<e2>", ",", "whereas", "staurosporine", "or", "PP2", "had", "no", "effect", "this", "decrease", "."], "h": {"id": "C1332824", "name": "C1332824#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022020", "name": "C0022020#ent", "pos": [11, 12]}}
{"token": ["To", "evaluate", "efficacy", ",", "dose", "response", "safety", ",", "and", "tolerability", "of", "adalimumab", "(", "D2E7", ")", "in", "disease", "modifying", "C0003191#ent", "<e1>", "DMARD", ")", "refractory", "patients", "with", "longstanding", ",", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [27, 28]}}
{"token": ["To", "compare", "the", "effects", "of", "treatment", "with", "and", "without", "'", "slow-acting", "C0003191#ent", "<e1>", "SAARDs", ")", "for", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [18, 19]}}
{"token": ["The", "neuro-epithelium:", "Stargardt's", "disease", "dominant", "C0751383#ent", "<e1>", "central", "or", "C0035334#ent", "<e2>", "progressive", "dystrophy", "of", "the", "cones", "and", "cystoid", "macular", "oedema"], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [9, 10]}}
{"token": ["We", "report", "on", "four", "children", "of", "both", "sexes", "from", "a", "highly", "inbred", "family", "hypotonia", ",", "C0221165#ent", "<e1>", "microcephaly", ",", "microphthalmia", ",", "congenital", "cataract", "optic", "atrophy", "C0005745#ent", "<e2>", ",", "kyphoscoliosis", ",", "short", "stature", "severe", "mental", "retardation", "and", "cerebral", "malformations"], "h": {"id": "C0221165", "name": "C0221165#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [25, 26]}}
{"token": ["The", "isolated", "catalytic", "domain", "the", "trigger", "factor", "retains", "the", "full", "C0022202#ent", "<e1>", "activity", "towards", "C0030956#ent", "<e2>", "but", "in", "a", "protein", "folding", "reaction", "activity", "is", "800-fold", "reduced", "and", "no", "longer", "inhibited", "by", "an", "unfolded", "protein"], "h": {"id": "C0022202", "name": "C0022202#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}}
{"token": ["Coincubation", "with", "the", "C0022202#ent", "<e1>", "blocked", "the", "labeling", "of", "these", "three", "C0030956#ent", "<e2>", "and", "shifted", "the", "alkylation", "by", "secosteroid", "to", "a", "single", "tryptic", "peptide", "(", "135EIIQNGHEEEPLENTWPAPYPHSK159", ",", "tritiated", "His142", ")", "."], "h": {"id": "C0022202", "name": "C0022202#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "the", "constitutive", "C1335271#ent", "<e1>", "in", "HUVEC", "is", "transcriptionally", "stimulated", "by", "PMA", "in", "a", "C0212694#ent", "<e2>", "."], "h": {"id": "C1335271", "name": "C1335271#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0212694", "name": "C0212694#ent", "pos": [17, 18]}}
{"token": ["Cold-reactive", "lymphocytotoxic", "antibodies", "(", "C1706240#ent", "<e1>", ")", "were", "investigated", "in", "sera", "from", "patients", "with", "C0026769#ent", "<e2>", "MS", ")", "in", "relation", "to", "disease", "activity"], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [14, 15]}}
{"token": ["A", "linkage", "and", "association", "of", "the", "C1706240#ent", "<e1>", "(", "protein-tyrosine", "phosphatase", "receptor-type", "C", ")", "C77", "G", "polymorphism", "and", "C0026769#ent", "<e2>", "MS", ")", "has", "been", "found", "in", "some", "studies", "but", "not", "in", "others", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}}
{"token": ["The", "C1706240#ent", "<e1>", "may", "play", "a", "role", "in", "the", "pathogenesis", "of", "acute", "exacerbation", "C0026769#ent", "<e2>", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [1, 2]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [13, 14]}}
{"token": ["Cold-reactive", "lymphocytotoxic", "antibodies", "(", "C1706240#ent", "<e1>", ")", "were", "investigated", "in", "sera", "from", "patients", "with", "multiple", "sclerosis", "C0026769#ent", "<e2>", ")", "in", "relation", "to", "disease", "activity"], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [16, 17]}}
{"token": ["However", ",", "among", "the", "three", "genes", "of", "the", "C0034678#ent", "<e1>", "studies", ",", "only", "C1366631#ent", "<e2>", "associated", "with", "susceptibility", "to", "HSN", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366631", "name": "C1366631#ent", "pos": [13, 14]}}
{"token": ["C0053867#ent", "<e1>", "treatment", "localised", "C1412727#ent", "<e2>", "predominantly", "within", "the", "Golgi", ",", "and", "reduced", "total", "C1412727#ent", "<e2>", "expression", "per", "cell", "."], "h": {"id": "C0053867", "name": "C0053867#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412727", "name": "C1412727#ent", "pos": [4, 5]}}
{"token": ["A", "total", "of", "2.5", "micromol/L", "C0053867#ent", "<e1>", "inhibited", "the", "dimerisation", "of", "C1412727#ent", "<e2>", ",", "whilst", "the", "expression", "of", "C1412727#ent", "<e2>", "monomer", "was", "reduced", "by", "5", "micromol/L", "C0053867#ent", "<e1>", "."], "h": {"id": "C0053867", "name": "C0053867#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412727", "name": "C1412727#ent", "pos": [11, 12]}}
{"token": ["Her", "C0040156#ent", "<e1>", "persisted", "after", "C1881373#ent", "<e2>", "withdrawal", ",", "so", "she", "was", "given", "methimazole", "and", ",", "once", "euthyroid", ",", "underwent", "near-total", "thyroidectomy"], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1881373", "name": "C1881373#ent", "pos": [5, 6]}}
{"token": ["The", "most", "common", "cause", "of", "C0040156#ent", "<e1>", "is", "the", "use", "of", "excessive", "doses", "of", "C1881373#ent", "<e2>", "for", "the", "treatment", "of", "hypothyroidism", ",", "non-toxic", "goiter", "thyroid", "carcinoma", "exogenous", "C0040156#ent", "<e1>", ")", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1881373", "name": "C1881373#ent", "pos": [14, 15]}}
{"token": ["A", "59-year-old", "woman", "with", "a", "history", "of", "nodular", "goiter", "C0040156#ent", "<e1>", "symptoms", "while", "on", "C1881373#ent", "<e2>"], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1881373", "name": "C1881373#ent", "pos": [14, 15]}}
{"token": ["We", "also", "present", "results", "of", "genetic", "interaction", "experiments", "C1335654#ent", "<e1>", "co-factors", "that", "are", "not", "consistent", "with", "C1332085#ent", "<e2>", "behaving", "as", "a", "dominant-negative", "factor"], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [8, 9]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1332085", "name": "C1332085#ent", "pos": [16, 17]}}
{"token": ["Similarly", ",", "C0252643#ent", "<e1>", "reduced", "the", "increased", "extracellular", "matrix", "deposition", "in", "afferent", "arterioles", "and", "C0268731#ent", "<e2>", "during", "NO", "inhibition", "."], "h": {"id": "C0252643", "name": "C0252643#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [14, 15]}}
{"token": ["We", "have", "reported", "a", "sexual", "dimorphism", "a", "strong", "effect", "of", "the", "COMT", "genotype", "on", "C0027404#ent", "<e1>", "symptoms", "and", "hypothesized", "that", "response", "to", "C0066677#ent", "<e2>", "treatment", "may", "be", "associated", "with", "COMT", "genotype", "."], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0066677", "name": "C0066677#ent", "pos": [22, 23]}}
{"token": ["This", "is", "a", "case", "report", "a", "patient", "with", "C0027404#ent", "<e1>", "treated", "simultaneously", "with", "C0066677#ent", "<e2>", "and", "tranylcypromine", "."], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0066677", "name": "C0066677#ent", "pos": [13, 14]}}
{"token": ["Among", "these", ",", "the", "functional", "polymorphism", "of", "the", "catechol-O-methyltransferase", "(", "COMT", ")", "gene", "is", "critically", "involved", "in", "the", "severity", "of", "C0027404#ent", "<e1>", "and", "in", "the", "response", "to", "the", "stimulant", "C0066677#ent", "<e2>", "."], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [20, 21]}, "relation": "may_be_treated_by", "t": {"id": "C0066677", "name": "C0066677#ent", "pos": [29, 30]}}
{"token": ["The", "antimicrobial", "susceptibility", "tests", "S.", "typhi", "by", "the", "disc", "diffusion", "method", "NCCLS", "breakpoints", "fail", "to", "detect", "the", "increasing", "MIC", "of", "C0008809#ent", "<e1>", ",", "leading", "to", "the", "inappropriate", "treatment", "of", "C0041466#ent", "<e2>", "C0008809#ent", "<e1>", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0041466", "name": "C0041466#ent", "pos": [29, 30]}}
{"token": ["In", "carcinoma", "of", "the", "cervix", ",", "high", "gene", "expression", "C1334122#ent", "<e1>", "with", "tumor", "invasiveness", "whereas", "lack", "of", "gene", "expression", "C4053520#ent", "<e2>", "is", "correlated", "with", "poor", "prognosis"], "h": {"id": "C1334122", "name": "C1334122#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4053520", "name": "C4053520#ent", "pos": [19, 20]}}
{"token": ["These", "results", "show", "that", "activation", "of", "C1312419#ent", "<e1>", "is", "sufficient", "to", "stimulate", "C2982484#ent", "<e2>", "translocation", "in", "3T3-L1", "adipocytes", "to", "an", "extent", "similar", "to", "insulin", "."], "h": {"id": "C1312419", "name": "C1312419#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [12, 13]}}
{"token": ["Commercially", "available", "purified", "collagenases", ",", "derived", "from", "Clostridium", "histolyticum", "contain", "two", "different", "classes", "of", "collagenase", ":", "C0009053#ent", "<e1>", "CI", ")", "and", "C0162745#ent", "<e2>", "CII", ")", "at", "a", "predetermined", "ratio", "."], "h": {"id": "C0009053", "name": "C0009053#ent", "pos": [16, 17]}, "relation": "has_chemical_structure", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [21, 22]}}
{"token": ["Although", "high", "TNF", "levels", "were", "associated", "with", "C0242723#ent", "<e1>", "and", "with", "C0020616#ent", "<e2>", ",", "they", "predicted", "fatal", "outcome", "in", "cerebral", "malaria", "of", "C0242723#ent", "<e1>", "and", "glucose", "concentrations"], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242723", "name": "C0242723#ent", "pos": [7, 8]}}
{"token": ["The", "existence", "of", "bifunctional", "enzymes", "with", "C0007641#ent", "<e1>", "and", "C0162969#ent", "<e2>", "activity", "is", "one", "of", "the", "reasons", "for", "C0007641#ent", "<e1>", "on", "chitosan", "hydrolysis", "."], "h": {"id": "C0162969", "name": "C0162969#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007641", "name": "C0007641#ent", "pos": [6, 7]}}
{"token": ["There", "was", "no", "correlation", "between", "testosterone", "levels", "and", "C1826421#ent", "<e1>", "at", "either", "the", "DR", "or", "the", "C0311284#ent", "<e2>", "at", "the", "beginning", "of", "the", "study", "."], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0311284", "name": "C0311284#ent", "pos": [16, 17]}}
{"token": ["These", "data", "do", "not", "suggest", "any", "difference", "between", "simple", "C3537249#ent", "<e1>", "calcitriol", "but", "do", "show", "that", "C0700482#ent", "<e2>", "was", "superior", "to", "either", "treatment", "for", "glucocorticoid", "induced", "bone", "loss"], "h": {"id": "C3537249", "name": "C3537249#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0700482", "name": "C0700482#ent", "pos": [16, 17]}}
{"token": ["Four", "patients", "had", "euthyroid", "goiter", "3", "had", "evidence", "of", "C0004364#ent", "<e1>", "2", "had", "chronic", "Hashimoto's", "thyroiditis", "1", "was", "C0271801#ent", "<e2>", ",", "1", "hyperthyroid", "and", "one", "has", "subacute", "thyroiditis"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0271801", "name": "C0271801#ent", "pos": [18, 19]}}
{"token": ["We", "have", "previously", "reported", "that", "third-generation", "BPs", "such", "as", "C2698656#ent", "<e1>", "ZOL", ")", "and", "C0012081#ent", "<e2>", "YM529", ")", "synergistically", "augment", "the", "effects", "of", "anticancer", "agents", "various", "cancer", "cells"], "h": {"id": "C2698656", "name": "C2698656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012081", "name": "C0012081#ent", "pos": [14, 15]}}
{"token": ["Mebudipine", "and", "C0671778#ent", "<e1>", "are", "two", "new", "dihydropyridine", "(", "C0220821#ent", "<e2>", ")", "Ca2", "+", "channel", "blockers", "have", "been", "synthesized", "by", "Mahmoudian", "et", "al.", "(", "1997", ")", "."], "h": {"id": "C0671778", "name": "C0671778#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220821", "name": "C0220821#ent", "pos": [9, 10]}}
{"token": ["In", "RAW", "264.7", "cells", "stimulated", "with", "C2697656#ent", "<e1>", ",", "addition", "of", "C0008269#ent", "<e2>", "at", "nontoxic", "concentrations", "not", "inhibit", "induction", "of", "TNF", "mRNA", "and", "NF-kappaB", "activity"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [11, 12]}}
{"token": ["This", "response", "was", "limited", "to", "monocytes", "when", "ultrapure", "C2697656#ent", "<e1>", "was", "used", ",", "and", "was", "inhibited", "in", "PDC", "by", "C0008269#ent", "<e2>", "treatment", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [19, 20]}}
{"token": ["C1144558#ent", "<e1>", "also", "activates", "anti-apoptotic", "C1704467#ent", "<e2>", "in", "the", "mitochondrial", "outer", "membrane", "changing", "it", "from", "a", "single-spanning", "to", "a", "multispanning", "conformation", "that", "binds", "the", "active", "Bax", "and", "inhibits", "cytochrome", "c", "release"], "h": {"id": "C1144558", "name": "C1144558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [5, 6]}}
{"token": ["This", "study", "investigated", "the", "effect", "of", "diagnosis", ",", "depressive", "symptoms", "history", "of", "C0001962#ent", "<e1>", "or", "tobacco", "abuse", "dependence", "on", "the", "C0015827#ent", "<e2>", "combat-related", "post-traumatic", "stress", "disorder", "PTSD", ")", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015827", "name": "C0015827#ent", "pos": [20, 21]}}
{"token": ["Endoxylanases", "are", "a", "group", "of", "C3540790#ent", "<e1>", "that", "hydrolyze", "the", "C1420369#ent", "<e2>", ",", "4-linked", "xylose", "backbone", "of", "xylans", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [10, 11]}}
{"token": ["It", "is", "concluded", "that", "elevated", "levels", "of", "C1412709#ent", "<e1>", "reflect", "the", "increased", "metabolism", "in", "patients", "with", "C0040156#ent", "<e2>", "."], "h": {"id": "C1412709", "name": "C1412709#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040156", "name": "C0040156#ent", "pos": [16, 17]}}
{"token": ["It", "is", "well-known", "that", "subjects", "with", "diabetes", "resulting", "from", "C0149521#ent", "<e1>", "prone", "to", "diabetic", "microvascular", "complications", "neuropathy", ",", "C0022658#ent", "<e2>", "and", "retinopathy", ")", "."], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [18, 19]}}
{"token": ["Many", "patients", "with", "C0149521#ent", "<e1>", "CP", ")", ",", "even", "in", "the", "absence", "of", "C0022658#ent", "<e2>", "are", "found", "to", "have", "abnormal", "urine", ",", "with", "persistent", "proteinuria", ",", "cylindruria", ",", "microhematuria", "and", "leukocyturia", "."], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [13, 14]}}
{"token": ["Some", "C0012544#ent", "<e1>", ",", "such", "as", "clodronate", "and", "C0286030#ent", "<e2>", ",", "can", "be", "incorporated", "into", "non-hydrolysable", "ATP", "analogues", "in", "cells", ",", "whereas", "the", "more", "potent", "anti-resorptive", "aminoalkylbisphosphonates", "are", "not", "metabolised", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [1, 2]}, "relation": "structural_class_of", "t": {"id": "C0286030", "name": "C0286030#ent", "pos": [8, 9]}}
{"token": ["Congenic", "and", "subcongenic", "rat", "strains", "confirmed", "the", "C0597336#ent", "<e1>", "QTLs", ")", "for", "facets", "of", "the", "C0524620#ent", "<e2>", "60.53", "and", "77.11", "Mb", "on", "chromosome", "4"], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [15, 16]}}
{"token": ["Between", "1", "and", "2", "%", "of", "patients", "who", "contract", "the", "illness", "experience", "blurred", "vision", "C0271185#ent", "<e1>", "and", "scotomas", "as", "a", "result", "of", "C3665438#ent", "<e2>", ",", "an", "associated", "clinical", "syndrome"], "h": {"id": "C0271185", "name": "C0271185#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3665438", "name": "C3665438#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "we", "assessed", "the", "levels", "of", "mitochondrial", "DNA", "mtDNA", ")", "and", "C0763047#ent", "<e1>", "COII", ")", "mRNA", "in", "RPTECs", "treated", "with", "C0282519#ent", "<e2>"], "h": {"id": "C0763047", "name": "C0763047#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0282519", "name": "C0282519#ent", "pos": [22, 23]}}
{"token": ["Interestingly", ",", "melanogenic", "inhibitor", "derived", "from", "JB/MS-W", "cells", "suppressed", "not", "only", "C0012524#ent", "<e1>", "but", "also", "C1413933#ent", "<e2>", "another", "enzyme", "functional", "in", "melanin", "production"], "h": {"id": "C0012524", "name": "C0012524#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413933", "name": "C1413933#ent", "pos": [15, 16]}}
{"token": ["The", "amount", "of", "C1415755#ent", "<e1>", "positive", "cells", "increased", "at", "24", "hr", "after", "exposure", "to", "C1418829#ent", "<e2>", "up", "to", "72", "hr", "."], "h": {"id": "C1415755", "name": "C1415755#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418829", "name": "C1418829#ent", "pos": [14, 15]}}
{"token": ["C1415884#ent", "<e1>", "interacts", "with", "phosphorylated", "ERKs", "but", "not", "with", "C0248813#ent", "<e2>", "JNK", ")", "or", "p38", "."], "h": {"id": "C1415884", "name": "C1415884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [9, 10]}}
{"token": ["When", "the", "DNA", "sequences", "are", "responsible", "for", "hormone-receptor", "binding", "for", "the", "increased", "C1710651#ent", "<e1>", "mRNA", "levels", "were", "deleted", ",", "no", "increase", "in", "C0035679#ent", "<e2>", "loading", "on", "C1710651#ent", "<e1>", "DNA", "was", "observed", "."], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1710651", "name": "C1710651#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "blocking", "C0243046#ent", "<e1>", "cultures", "after", "the", "C2917660#ent", "<e2>", "exposure", "also", "prevented", "this", "delayed", "neuronal", "death"], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [8, 9]}}
{"token": ["The", "C0243046#ent", "<e1>", "and", "EEL", "in", "unfed", "cockerels", "influenced", "true", "available", "C2917660#ent", "<e2>", "TAAA", ")", "values", "."], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [11, 12]}}
{"token": ["Similarly", ",", "the", "number", "of", "nerve", "impulses", "evoked", "in", "monkey", "C0034678#ent", "<e1>", "increased", "with", "dot", "height", "did", "the", "widths", "of", "C0003873#ent", "<e2>", "receptive", "fields"], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [20, 21]}}
{"token": ["Ectopic", "expression", "of", "either", "C0072476#ent", "<e1>", "or", "Pim-2", "in", "Pim-1(-/-)/Pim-2(-/-", ")", "cells", "restores", "transformation", "by", "C0080279#ent", "<e2>", ",", "strongly", "suggesting", "that", "either", "C0072476#ent", "<e1>", "or", "Pim-2", "is", "required", "for", "v-Abl-mediated", "tumorigenesis", "."], "h": {"id": "C0080279", "name": "C0080279#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0072476", "name": "C0072476#ent", "pos": [4, 5]}}
{"token": ["In", "C0080279#ent", "<e1>", "expression", "of", "C0072476#ent", "<e2>", "and", "Pim-2", ",", "but", "not", "Pim-3", ",", "is", "dependent", "on", "Abl", "kinase", "activity"], "h": {"id": "C0080279", "name": "C0080279#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072476", "name": "C0072476#ent", "pos": [5, 6]}}
{"token": ["A", "preferential", "C2936790#ent", "<e1>", "ICI", "118,551", "1", "nM-1", "microM", ")", "did", "not", "alter", "C3536742#ent", "<e2>", "overflows", "in", "either", "group", "."], "h": {"id": "C2936790", "name": "C2936790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [13, 14]}}
{"token": ["These", "changes", "in", "C1538057#ent", "<e1>", "were", "abolished", "by", "adding", "Co2+", "C1417500#ent", "<e2>", "+", "to", "Ca(2+)-free", "medium", "."], "h": {"id": "C1538057", "name": "C1538057#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [10, 11]}}
{"token": ["To", "assess", "efficacy", "of", "intraarticular", "administration", "lornoxicam", "(", "C0055477#ent", "<e1>", ")", "in", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0055477", "name": "C0055477#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["To", "assess", "efficacy", "of", "intraarticular", "administration", "lornoxicam", "(", "C0055477#ent", "<e1>", ")", "in", "patients", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C0055477", "name": "C0055477#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["One", "group", "of", "four", "monosomic-derived", "plants", "differed", "for", "the", "enzymes", "GOT", "and", "C0207890#ent", "<e1>", ",", "and", "all", "four", "plants", "had", "a", "C3810522#ent", "<e2>", "pattern", "."], "h": {"id": "C0207890", "name": "C0207890#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3810522", "name": "C3810522#ent", "pos": [21, 22]}}
{"token": ["In", "conclusion", ",", "C0875947#ent", "<e1>", "safe", ",", "convenient", ",", "and", "effective", "in", "treating", "C0162316#ent", "<e2>", "PD", "patients", "."], "h": {"id": "C0875947", "name": "C0875947#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "C0875947#ent", "<e1>", "sucrose", "is", "safe", "and", "effective", "in", "the", "management", "of", "C0162316#ent", "<e2>", "severely", "iron-deficient", "and", "anemic", "hemodialysis", "patients", "receiving", "rHuEPO", "."], "h": {"id": "C0875947", "name": "C0875947#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [14, 15]}}
{"token": ["U-73122", "and", "propranolol", ",", "a", "C1335404#ent", "<e1>", "reduced", "the", "ET-1-stimulated", "C0034152#ent", "<e2>", "27", "accumulation", "."], "h": {"id": "C1335404", "name": "C1335404#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [10, 11]}}
{"token": ["High", "levels", "of", "C0699919#ent", "<e1>", "activity", "were", "found", "in", "DU145", ",", "C1366526#ent", "<e2>", ",", "and", "LNCaP", "bone", "tumors", ",", "although", "the", "C1366526#ent", "<e2>", "and", "LNCaP", "cells", "had", "exhibited", "low", "cathepsin", "B", "expression", "in", "vitro"], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [11, 12]}}
{"token": ["We", "hypothesized", "that", "cell-matrix", "interactions", "affect", "the", "expression", "and", "activity", "of", "C0699919#ent", "<e1>", "L", "and", "their", "inhibitors", "in", "the", "prostate", "cancer", "cell", "lines", "C1366526#ent", "<e2>", "and", "DU145", "."], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "a", "single", "1-hour", "C0033051#ent", "<e1>", "infusion", "in", "patients", "with", "severe", "C0018802#ent", "<e2>", "an", "haemodynamic", "improvement", "associated", "with", "reduction", "of", "previously", "elevated", "circulating", "NE", "levels", "."], "h": {"id": "C0033051", "name": "C0033051#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["To", "our", "knowledge", ",", "this", "is", "the", "first", "case", "report", "C0242342#ent", "<e1>", "with", "both", "C0020625#ent", "<e2>", "and", "suggestive", "hypoglycemia", "."], "h": {"id": "C0242342", "name": "C0242342#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [14, 15]}}
{"token": ["The", "present", "report", "shows", "that", "C0242342#ent", "<e1>", "be", "associated", "with", "C0020625#ent", "<e2>", "and", "illustrates", "the", "need", "to", "include", "C0020625#ent", "<e2>", "as", "an", "initial", "symptom", "in", "the", "differential", "diagnosis", "C0242342#ent", "<e1>"], "h": {"id": "C0242342", "name": "C0242342#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [10, 11]}}
{"token": ["Neither", "heparin", "nor", "C0019139#ent", "<e1>", "could", "inhibit", "the", "procoagulant", "alteration", "of", "C3889380#ent", "<e2>", "RBC", "membranes", "induced", "by", "C", "'", "activation", "even", "at", "concentrations", "which", "inhibited", "the", "haemolysis", "completely", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889380", "name": "C3889380#ent", "pos": [11, 12]}}
{"token": ["The", "apo", "B", "signal", "peptide", "genotypes", "are", "transmitted", "in", "a", "manner", "consistent", "with", "C2936739#ent", "<e1>", "of", "inheritance", "with", "two", "C0002085#ent", "<e2>", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [19, 20]}}
{"token": ["Family", "data", "a", "large", "number", "of", "families", "establish", "an", "C2936739#ent", "<e1>", "of", "inheritance", "of", "the", "three", "C0002085#ent", "<e2>", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [16, 17]}}
{"token": ["When", "rats", "were", "fed", "these", "two", "drugs", "and", "then", "given", "C0066485#ent", "<e1>", "by", "stomach", "intubation", "there", "was", "a", "5-fold", "decrease", "of", "C1538973#ent", "<e2>", "mRNA", "within", "3", "h."], "h": {"id": "C0066485", "name": "C0066485#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1538973", "name": "C1538973#ent", "pos": [21, 22]}}
{"token": ["By", "use", "of", "EcoRI", ",", "Xho", "I", "Bgl", "II", ",", "Xba", "I", ",", "C0011513#ent", "<e1>", ",", "HincII", ",", "and", "C1122828#ent", "<e2>", "a", "total", "of", "28", "restriction", "sites", "mapped", "."], "h": {"id": "C0011513", "name": "C0011513#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1122828", "name": "C1122828#ent", "pos": [19, 20]}}
{"token": ["Refeeding", "diets", "containing", "fructose", "(", "sucrose", ",", "turanose", ",", "melezitose", ",", "and", "monosaccharide", "equivalents", "fructose", ")", "increased", "the", "responses", "of", "C1333652#ent", "<e1>", ",", "ME", ",", "FAS", ",", "and", "C1420758#ent", "<e2>", "."], "h": {"id": "C1333652", "name": "C1333652#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1420758", "name": "C1420758#ent", "pos": [28, 29]}}
{"token": ["Thus", "transesophageal", "echocardiography", "recognition", "of", "C1541923#ent", "<e1>", "particularly", "in", "the", "presence", "of", "underlying", "C3258293#ent", "<e2>"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3258293", "name": "C3258293#ent", "pos": [13, 14]}}
{"token": ["Multiple", "endocrine", "neoplasia", "type", "1", "C0694884#ent", "<e1>", ")", "is", "a", "C1853733#ent", "<e2>", "by", "parathyroid", "hyperplasia", "pancreatic", "endocrine", "tumors", "and", "pituitary", "adenomas"], "h": {"id": "C0694884", "name": "C0694884#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1853733", "name": "C1853733#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "the", "authors", "tested", "the", "efficacy", "of", "the", "C1415495#ent", "<e1>", "intervention", "on", "reducing", "adolescent", "C0001975#ent", "<e2>", ",", "marijuana", ",", "and", "cigarette", "use"], "h": {"id": "C1415495", "name": "C1415495#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [17, 18]}}
{"token": ["C0007785#ent", "<e1>", "hypoglycemia", ",", "and", "C0085543#ent", "<e2>", "well", "known", "examples", "of", "such", "disease", "processes"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [5, 6]}}
{"token": ["The", "non-CCE", "component", "was", "inhibited", "by", "a", "C1516869#ent", "<e1>", "HOE140", ";", "1", "microM", ")", "and", "a", "C0031669#ent", "<e2>", "PLC", ")", "inhibitor", "(", "U73122", ";", "10", "microM", ")", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [16, 17]}}
{"token": ["A", "new", "C3537002#ent", "<e1>", "barbexaclone", ")", "was", "tried", "in", "48", "patients", "suffering", "from", "C0014544#ent", "<e2>", "and", "presenting", "a", "total", "of", "67", "types", "of", "crises", "."], "h": {"id": "C3537002", "name": "C3537002#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}}
{"token": ["Report", "of", "a", "case", "of", "C0016952#ent", "<e1>", "due", "to", "C0268155#ent", "<e2>"], "h": {"id": "C0016952", "name": "C0016952#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0268155", "name": "C0268155#ent", "pos": [9, 10]}}
{"token": ["Genotypes", "studied", "were", "heterozygotes", "for", "the", "C0268155#ent", "<e1>", "and", "GALT", "forms", "of", "C0016952#ent", "<e2>", ",", "the", "Duarte-variant", "GALT", ",", "and", "Philadelphia-variant", "C0268155#ent", "<e1>", "alleles", "."], "h": {"id": "C0016952", "name": "C0016952#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0268155", "name": "C0268155#ent", "pos": [6, 7]}}
{"token": ["In", "skin", "fibroblasts", "patients", "presenting", "with", "C0016952#ent", "<e1>", ",", "either", "from", "galactose", "1-phosphate", "uridyltransferase", "C0268155#ent", "<e2>", "a", "deficit", "in", "extracellular", "glucose", "utilization", "was", "observed", "."], "h": {"id": "C0016952", "name": "C0016952#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0268155", "name": "C0268155#ent", "pos": [14, 15]}}
{"token": ["The", "inhibitions", "exerted", "by", "the", "different", "C0031428#ent", "<e1>", "on", "3,3'-T2", "sulfation", "by", "C1420517#ent", "<e2>", "correlated", "better", "with", "the", "effects", "observed", "in", "male", "than", "with", "those", "in", "female", "liver", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420517", "name": "C1420517#ent", "pos": [12, 13]}}
{"token": ["At", "10(-3", ")", "M", ",", "various", "C0021236#ent", "<e1>", "including", "n-acetylserotonin", ",", "melatonin", ",", "5-methoxytryptamine", ",", "C0000589#ent", "<e2>", ",", "and", "5-hydroxyindole", "acetic", "acid", "decreased", "by", "10", "to", "30", "%", "5", "alpha-reduced", "product", "formation", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0000589", "name": "C0000589#ent", "pos": [15, 16]}}
{"token": ["Single", "cell", "measurements", "showed", "that", "the", "M1", "receptor", "functionally", "active", "linked", "to", "acute", "increases", "in", "intracellular", "free", "calcium", "as", "the", "M1", "receptor", "antagonist", "C0031978#ent", "<e1>", "blocked", "the", "Ca2", "+", "-mobilizing", "effect", "of", "oxotremorine", "M", "a", "C3536929#ent", "<e2>", "."], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3536929", "name": "C3536929#ent", "pos": [35, 36]}}
{"token": ["Administration", "of", "the", "m1", "mAChR", "antagonist", "C0031978#ent", "<e1>", "inhibited", "the", "stimulatory", "effect", "of", "the", "C3536929#ent", "<e2>", "carbachol", "on", "Ca", "transients", "."], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536929", "name": "C3536929#ent", "pos": [14, 15]}}
{"token": ["This", "C0079429#ent", "<e1>", "is", "located", "at", "chromosome", "Xq27", "the", "spliced", "variant", "is", "named", "C3273279#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273279", "name": "C3273279#ent", "pos": [13, 14]}}
{"token": ["The", "bone-marrow", "response", "of", "34", "Yemenite", "Jews", "with", "and", "without", "C0027947#ent", "<e1>", ")", "to", "an", "intravenous", "injection", "of", "200", "mg", "of", "C0770560#ent", "<e2>", "studied", "and", "compared", "with", "the", "response", "of", "18", "healthy", "control", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0770560", "name": "C0770560#ent", "pos": [21, 22]}}
{"token": ["Docking", "studies", "of", "the", "protonated", "ligand", "predicted", "both", "C0017205#ent", "<e1>", "and", "trans", "ligand", "conformers", "to", "favorably", "interact", "with", "the", "C1708300#ent", "<e2>", "its", "hypothesized", "binding", "cavity"], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1708300", "name": "C1708300#ent", "pos": [19, 20]}}
{"token": ["RNAi", "knock", "down", "C1839259#ent", "<e1>", ")", "of", "SKAP-55", "in", "T-cell", "lines", "showed", "an", "increase", "in", "C0079471#ent", "<e2>", "activation", ",", "while", "over-expression", "of", "SKAP-55", "inhibited", "activation", "of", "ERK", "and", "its", "transcriptional", "target", "ELK", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [15, 16]}}
{"token": ["Eighty-nine", "volunteer", "subjects", "a", "test", "anxiety", "scale", "C0559483#ent", "<e1>", ")", "and", "an", "effective", "study", "test", "C1420459#ent", "<e2>", ")", "at", "the", "beginning", "of", "the", "spring", "semester", "."], "h": {"id": "C0559483", "name": "C0559483#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420459", "name": "C1420459#ent", "pos": [15, 16]}}
{"token": ["(+)-Glaucine", "(", "2", "-", "18", "microM", ")", "competitively", "inhibited", "contractions", "induced", "by", "noradrenaline", "and", "C0025681#ent", "<e1>", "with", "a", "C1419619#ent", "<e2>", "value", "of", "about", "6", "."], "h": {"id": "C0025681", "name": "C0025681#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419619", "name": "C1419619#ent", "pos": [18, 19]}}
{"token": ["It", "was", "found", "that", "there", "was", "a", "clear", "distinction", "in", "the", "ratios", "between", "normals", ",", "C0002312#ent", "<e1>", "carriers", ",", "alpha", "thalassaemia", "2", "carriers", ",", "and", "those", "with", "C3161174#ent", "<e2>"], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C3161174", "name": "C3161174#ent", "pos": [27, 28]}}
{"token": ["The", "best", "routine", "diagnostic", "method", "detect", "individuals", "with", "C0002312#ent", "<e1>", "staining", "reticulocyte-enriched", "red", "cell", "preparations", "with", "brilliant", "cresyl", "blue", "detect", "C3161174#ent", "<e2>", "inclusions", "."], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C3161174", "name": "C3161174#ent", "pos": [20, 21]}}
{"token": ["The", "C0029408#ent", "<e1>", "was", "characteristically", "intermittent", "and", "controlled", "by", "low", "dose", "prednisone", ",", "C0021246#ent", "<e2>", ",", "and", "tetracycline", "therapy"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [13, 14]}}
{"token": ["Celecoxib", "reversed", "signs", "of", "C0029408#ent", "<e1>", "and", "pain", "in", "an", "animal", "model", "effectively", "as", "C0021246#ent", "<e2>", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [14, 15]}}
{"token": ["The", "radical", "anions", "several", "C0046436#ent", "<e1>", "were", "formed", "by", "the", "rapid", "reaction", "of", "the", "parent", "molecules", "C0720930#ent", "<e2>", "electrons", "or", "with", "various", "pyrimidine", "electron", "adducts", "."], "h": {"id": "C0046436", "name": "C0046436#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0720930", "name": "C0720930#ent", "pos": [16, 17]}}
{"token": ["Severe", "C0023364#ent", "<e1>", "manifests", "as", "C0034063#ent", "<e2>", "to", "acute", "respiratory", "distress", "syndrome", "polyuric", "acute", "renal", "failure", "ARF", ")", "."], "h": {"id": "C0023364", "name": "C0023364#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [5, 6]}}
{"token": ["The", "latter", "cases", "are", "usually", "accompanied", "by", "C0025517#ent", "<e1>", "including", "insulin", "resistance", "diabetes", "mellitus", "hyperlipemia", ",", "progressive", "C0019202#ent", "<e2>", "anabolic", "state"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [17, 18]}}
{"token": ["The", "loss", "of", "ATP7A", "or", "ATP7B", "function", "is", "associated", "with", "severe", "C0025517#ent", "<e1>", "Menkes", "disease", ",", "and", "C0019202#ent", "<e2>"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [17, 18]}}
{"token": ["V.", "Other", "inherited", "C0025517#ent", "<e1>", "(", "1", ")", "aminoacidopathies", "(", "cystinosis", ",", "C0019202#ent", "<e2>", "ochronosis", ",", "Chediak-Higashi", "syndrome", ",", "(", "2", ")", "hemochromatosis", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [12, 13]}}
{"token": ["Differential", "diagnosis", "hospital", "admission", "on", "C0025517#ent", "<e1>", "as", "glycogenoses", ",", "galactosaemia", ",", "tyrosinosis", ",", "or", "C0019202#ent", "<e2>"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [15, 16]}}
{"token": ["The", "determination", "of", "cellular", "content", "of", "octadecylphosphocholine", "(", "D-19391", ")", "and", "C0068006#ent", "<e1>", "(", "HePC", ",", "D-18506", ")", ",", "two", "C0003392#ent", "<e2>", "the", "alkylphosphocholine", "group", ",", "using", "capillary", "gas", "chromatography", "described", "."], "h": {"id": "C0068006", "name": "C0068006#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [20, 21]}}
{"token": ["C1417827#ent", "<e1>", "mRNA", "is", "undetectable", "by", "in", "situ", "hybridization", "C0020498#ent", "<e2>", ")", "in", "50", "%", "of", "non-small-cell", "lung", "cancers", "NSCLC", ")", "."], "h": {"id": "C1417827", "name": "C1417827#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020498", "name": "C0020498#ent", "pos": [9, 10]}}
{"token": ["C0022635#ent", "<e1>", "evaluated", "for", "the", "treatment", "of", "C0017563#ent", "<e2>", "a", "placebo-controlled", ",", "double-blind", "study", "the", "rhesus", "monkeys", "Macaca", "mulatta"], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [7, 8]}}
{"token": ["Our", "results", "suggest", "that", "C0175820#ent", "<e1>", "dominate", "in", "black", "and", "red", "currants", "whereas", "C0919289#ent", "<e2>", "and", "phenolic", "acids", "the", "predominant", "phenolic", "compounds", "green", "and", "white", "currants"], "h": {"id": "C0175820", "name": "C0175820#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919289", "name": "C0919289#ent", "pos": [13, 14]}}
{"token": ["The", "binding", "of", "glucose", "by", "C3538683#ent", "<e1>", "or", "succinate", "by", "C3813197#ent", "<e2>", "did", "not", "result", "in", "any", "chemical", "alteration", "the", "substrates", "."], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3813197", "name": "C3813197#ent", "pos": [10, 11]}}
{"token": ["Although", "C1418856#ent", "<e1>", "to", "C1333714#ent", "<e2>", "also", "exhibited", "tachyphylaxis", ",", "prolonged", "infusion", "of", "C1333714#ent", "<e2>", "did", "not", "enhance", "the", "pancreatic", "polypeptide", "response", "food", "."], "h": {"id": "C1418856", "name": "C1418856#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [4, 5]}}
{"token": ["Based", "on", "total", "enzyme", "activities", ",", "C1418773#ent", "<e1>", "appears", "to", "be", "more", "suitable", "than", "C1456377#ent", "<e2>", "but", "the", "latter", "exhibits", "better", "volumetric", "productivities", "."], "h": {"id": "C1418773", "name": "C1418773#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [14, 15]}}
{"token": ["Their", "ability", "to", "produce", "the", "antibiotic", "in", "C1418773#ent", "<e1>", "in", "relation", "to", "their", "capacity", "to", "do", "so", "in", "C1456377#ent", "<e2>", "was", "evaluated", "."], "h": {"id": "C1418773", "name": "C1418773#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [18, 19]}}
{"token": ["We", "developed", "small", "C0030956#ent", "<e1>", "containing", "the", "conserved", "C-terminal", "sequence", "C3811665#ent", "<e2>", "to", "investigate", "whether", "these", "C0030956#ent", "<e1>", "can", "interfere", "with", "the", "DNA", "damage", "pathway"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811665", "name": "C3811665#ent", "pos": [10, 11]}}
{"token": ["The", "first", "test", "of", "intranasal", "recombinant", "human", "C0751599#ent", "<e1>", "IFN-beta", "ser", ")", "as", "prophylaxis", "against", "common", "C0009443#ent", "<e2>", "is", "reported", "."], "h": {"id": "C0751599", "name": "C0751599#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [16, 17]}}
{"token": ["Although", "C1422646#ent", "<e1>", "bone", "marrow", "cells", "respond", "to", "erythropoietin", "in", "vitro", "in", "stressed", "conditions", "where", "C0538674#ent", "<e2>", "elevated", ",", "suppression", "of", "C0538674#ent", "<e2>", "potentiate", "the", "erythropoietic", "response", "this", "disease", "."], "h": {"id": "C1422646", "name": "C1422646#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0538674", "name": "C0538674#ent", "pos": [15, 16]}}
{"token": ["Isoproterenol", "and", "C0770456#ent", "<e1>", "were", "used", "to", "stimulate", "the", "parotid", "gland", "the", "C0771711#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [12, 13]}}
{"token": ["It", "is", "concluded", "that", "amylase", "released", "by", "C0770456#ent", "<e1>", "from", "the", "parotid", "gland", "not", "from", "the", "C0771711#ent", "<e2>", "elevated", "the", "enzyme", "activity", "the", "submandibular", "and", "sublingual", "glands"], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [16, 17]}}
{"token": ["We", "evaluated", "the", "effect", "of", "additional", "C0292818#ent", "<e1>", "on", "plasma", "C0939237#ent", "<e2>", "concentrations", "in", "HIV-infected", "children", "receiving", "rifampicin-based", "treatment", "for", "tuberculosis", "."], "h": {"id": "C0292818", "name": "C0292818#ent", "pos": [6, 7]}, "relation": "part_of", "t": {"id": "C0939237", "name": "C0939237#ent", "pos": [10, 11]}}
{"token": ["To", "evaluate", "the", "long-term", "safety", "and", "effectiveness", "of", "C0292818#ent", "<e1>", ",", "nelfinavir", ",", "and", "C0939237#ent", "<e2>", "in", "antiretroviral-experienced", ",", "initially", "protease", "inhibitor", ",", "human", "immunodeficiency", "virus", "children", "."], "h": {"id": "C0292818", "name": "C0292818#ent", "pos": [8, 9]}, "relation": "part_of", "t": {"id": "C0939237", "name": "C0939237#ent", "pos": [14, 15]}}
{"token": ["The", "class", "II", "products", "the", "major", "C0024518#ent", "<e1>", "also", "called", "Ia", "antigens", "are", "composed", "of", "two", "C1305923#ent", "<e2>", "the", "alpha", "and", "beta", "chains", "both", "encoded", "within", "the", "major", "C0024518#ent", "<e1>"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [6, 7]}}
{"token": ["We", "studied", "the", "antigen-presenting", "capacity", "of", "mouse", "L", "transfected", "with", "genes", "encoding", "C1305923#ent", "<e1>", "the", "major", "histocompatibility", "complex", "(", "C0024518#ent", "<e2>", ")", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [19, 20]}}
{"token": ["Each", "of", "the", "two", "factors", "consists", "of", "two", "C1305923#ent", "<e1>", "an", "antigen-binding", "chain", "(", "ABC", ")", "and", "a", "major", "C0024518#ent", "<e2>", "MHC", ")", "chain", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [19, 20]}}
{"token": ["C1415975#ent", "<e1>", "binding", "to", "PLL", "was", "examined", "at", "different", "C1705397#ent", "<e2>", "and", "ionic", "strengths"], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [9, 10]}}
{"token": ["To", "compare", "the", "analgesic", "efficacy", "safety", "of", "nonprescription", "doses", "C0546873#ent", "<e1>", "ibuprofen", ",", "and", "placebo", "in", "patients", "with", "C0029408#ent", "<e2>", "(", "OA", ")", "of", "the", "knee", "."], "h": {"id": "C0546873", "name": "C0546873#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [18, 19]}}
{"token": ["We", "propose", "that", "PUF-I", "is", "a", "critical", "modulator", "of", "transcriptional", "activity", "pituitary", "cells", "has", "a", "central", "role", "in", "the", "stimulation", "of", "C0812327#ent", "<e1>", "the", "mammalian", "C0032002#ent", "<e2>"], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [25, 26]}}
{"token": ["Our", "data", "suggest", "that", "ERK1/2", "suppression", "is", "an", "obligatory", "step", "in", "the", "dopaminergic", "control", "of", "C0812327#ent", "<e1>", "that", "bidirectional", "control", "ERK1/2", "function", "in", "the", "C0032002#ent", "<e2>", "may", "provide", "a", "key", "mechanism", "for", "endocrine", "gene", "control"], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [24, 25]}}
{"token": ["In", "vitro", "kinase", "activity", "assays", "together", "with", "protein", "binding", "competition", "studies", ",", "reveal", "that", "C0028326#ent", "<e1>", "does", "not", "displace", "C2987236#ent", "<e2>", "from", "the", "inter-SH2", "domain", "and", "indicate", "that", "C0028326#ent", "<e1>", "can", "form", "an", "active", "heterotrimeric", "complex", "PI3K"], "h": {"id": "C0028326", "name": "C0028326#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2987236", "name": "C2987236#ent", "pos": [19, 20]}}
{"token": ["However", ",", "little", "is", "known", "about", "the", "secretory", "pattern", "atrial", "natriuretic", "peptide", "C1417807#ent", "<e1>", ")", "in", "this", "C0039082#ent", "<e2>", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [17, 18]}}
{"token": ["The", "diurnal", "increase", "in", "C1417807#ent", "<e1>", "in", "the", "the", "C0039082#ent", "<e2>", "to", "the", "diurnal", "decrease", "in", "C1417807#ent", "<e1>", "reported", "in", "normal", "subjects"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [9, 10]}}
{"token": ["Ganglion", "blockade", "with", "C0062637#ent", "<e1>", "did", "not", "influence", "CGRP", "release", "by", "C1425216#ent", "<e2>", "but", "abolished", "CGRP", "mediated", "myocardial", "PKCepsilon", "activation", "."], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425216", "name": "C1425216#ent", "pos": [11, 12]}}
{"token": ["C1366876#ent", "<e1>", "is", "a", "C1456380#ent", "<e2>", "splice", "isoform", "that", "is", "distinctively", "activated", "by", "mitogenic", "stimuli", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [4, 5]}}
{"token": ["C1366876#ent", "<e1>", "is", "one", "of", "three", "known", "alternative", "spliced", "forms", "the", "stress-activated", "mitogen-activated", "protein", "kinase", "p38", "C1456380#ent", "<e2>", ")", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [16, 17]}}
{"token": ["C1366876#ent", "<e1>", "is", "a", "splicing", "variant", "C1456380#ent", "<e2>", "that", "harbors", "a", "unique", "carboxy-terminus", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [6, 7]}}
{"token": ["The", "immunohistochemical", "localization", "of", "plasma", "retinol-binding", "protein", "RBP", ")", ",", "cellular", "retinol-binding", "protein", "CRBP", ")", ",", "and", "transthyretin", "(", "C1421224#ent", "<e1>", ")", "was", "studied", "in", "rat", "C0771711#ent", "<e2>", "."], "h": {"id": "C1421224", "name": "C1421224#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [26, 27]}}
{"token": ["ED-A", "and", "C1706331#ent", "<e1>", ",", "of", "human", "C1367472#ent", "<e2>", "was", "determined", ",", "in", "order", "to", "show", "whether", "any", "similarity", "was", "present", "between", "the", "two", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1367472", "name": "C1367472#ent", "pos": [7, 8]}}
{"token": ["This", "suggests", "that", "there", "are", "no", "other", "essential", "functions", "of", "the", "C1512600#ent", "<e1>", "homologs", "aside", "from", "C0021088#ent", "<e2>", "activity", "."], "h": {"id": "C1512600", "name": "C1512600#ent", "pos": [11, 12]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021088", "name": "C0021088#ent", "pos": [16, 17]}}
{"token": ["Hematoma", "can", "occur", "even", "while", "correctly", "managed", "C0003280#ent", "<e1>", "treatment", "because", "of", "drug", "interactions", "C0012739#ent", "<e2>", "caused", "by", "liver", "disease"], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [14, 15]}}
{"token": ["Collectively", ",", "these", "data", "suggest", "that", "C0015133#ent", "<e1>", "3'-demethylation", "is", "mediated", "mainly", "by", "C1142644#ent", "<e2>", "and", "to", "a", "minor", "extent", "by", "CYP1A2", "and", "2E1", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [13, 14]}}
{"token": ["The", "utility", "of", "the", "method", "is", "demonstrated", "in", "the", "discovery", "that", "topotecan", "and", "C0015133#ent", "<e1>", "are", "ligands", "of", "pregnane", "X", "receptor", "induce", "C1142644#ent", "<e2>", "transcription", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [13, 14]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [22, 23]}}
{"token": ["In", "the", "present", "work", ",", "we", "assessed", "the", "effects", "of", "C4055175#ent", "<e1>", "on", "12-O-", "tetradecanoylphorbol-13-acetate", "(TPA)-induced", "expression", "of", "C1565860#ent", "<e2>", "(", "COX-2", ")", "in", "female", "ICR", "mouse", "skin"], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [18, 19]}}
{"token": ["While", "C4055175#ent", "<e1>", "inhibited", "C1565860#ent", "<e2>", "expression", ",", "turmeric", "oils", "no", "effect", "levels", "of", "C1565860#ent", "<e2>", "mRNA", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [4, 5]}}
{"token": ["A", "recombinant", "DNA", "study", "was", "performed", "in", "a", "three-generation", "family", "with", "8", "typical", "cases", "of", "C0027126#ent", "<e1>", "DM", ")", "and", "with", "one", "case", "of", "Duchenne", "muscular", "dystrophy", "C1414083#ent", "<e2>", ")", "."], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [27, 28]}}
{"token": ["His", "22-year-old", "sister", "with", "typical", "clinical", ",", "EMG", "and", "recombinant", "DNA", "findings", "characteristic", "for", "C0027126#ent", "<e1>", "also", "a", "carrier", "of", "C1414083#ent", "<e2>", "deletion", "."], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [20, 21]}}
{"token": ["We", "present", "a", "case", "report", "a", "patient", "with", "C0019693#ent", "<e1>", "presented", "with", "C0000737#ent", "<e2>", "distension", "and", "was", "found", "to", "have", "an", "intraabdominal", "type", "of", "Burkitt's", "lymphoma"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [12, 13]}}
{"token": ["The", "candidate", "C1417679#ent", "<e1>", "of", "fibrosis", "were", "Spp1", ",", "Ctgf", ",", "and", "Cyp2c39", "and", "moreover", "C1538466#ent", "<e2>", "and", "Spp1", "were", "regarded", "as", "the", "candidate", "C1417679#ent", "<e1>", "of", "carcinogenesis", "."], "h": {"id": "C1538466", "name": "C1538466#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}}
{"token": ["C0006388#ent", "<e1>", "is", "a", "potent", "non-selective", "C0001641#ent", "<e2>", "for", "the", "topical", "treatment", "increased", "intraocular", "pressure", "patients", "with", "chronic", "open", "angle", "glaucoma", "ocular", "hypertension"], "h": {"id": "C0006388", "name": "C0006388#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [6, 7]}}
{"token": ["Genetic", "defects", "C1333356#ent", "<e1>", "lead", "to", "three", "distinct", "inheritable", "diseases", "xeroderma", "pigmentosa", "Cockayne", "syndrome", "and", "C1955934#ent", "<e2>", ",", "with", "xeroderma", "pigmentosa", "patients", "being", "highly", "susceptible", "to", "skin", "cancer"], "h": {"id": "C1333356", "name": "C1333356#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C1955934", "name": "C1955934#ent", "pos": [15, 16]}}
{"token": ["Mutations", "in", "the", "C1333356#ent", "<e1>", "in", "xeroderma", "pigmentosum", "XP", ")", "and", "C1955934#ent", "<e2>", "(", "TTD", ")", ",", "the", "phenotypes", "of", "which", "are", "often", "intricate", "."], "h": {"id": "C1333356", "name": "C1333356#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C1955934", "name": "C1955934#ent", "pos": [11, 12]}}
{"token": ["Mutations", "in", "the", "largest", "subunits", ",", "the", "XPB", "and", "C1333356#ent", "<e1>", "are", "associated", "with", "inherited", "disorders", "xeroderma", "pigmentosum", "Cockayne's", "syndrome", "and", "C1955934#ent", "<e2>", "."], "h": {"id": "C1333356", "name": "C1333356#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C1955934", "name": "C1955934#ent", "pos": [21, 22]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "the", "effect", "of", "recombinant", "C1522405#ent", "<e1>", "in", "a", "79-year-old", "Japanese", "man", "with", "C1276801#ent", "<e2>", "a", "rare", "type", "of", "cutaneous", "metastasis", "gastric", "cancer"], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1276801", "name": "C1276801#ent", "pos": [19, 20]}}
{"token": ["Paired", "sera", "21", "patients", "with", "C0275518#ent", "<e1>", "assayed", "for", "C4284041#ent", "<e2>", "by", "immunofluorescence", "on", "mouse", "kidney/stomach", "substrates", "."], "h": {"id": "C0275518", "name": "C0275518#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4284041", "name": "C4284041#ent", "pos": [9, 10]}}
{"token": ["More", "than", "a", "decade", "after", "the", "discovery", "of", "the", "C0250870#ent", "<e1>", "our", "pursuit", "of", "the", "molecular", "mechanisms", "C0919445#ent", "<e2>", "revealed", "a", "significant", "divergence", "of", "C0919445#ent", "<e2>", "from", "other", "serpins", "."], "h": {"id": "C0250870", "name": "C0250870#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919445", "name": "C0919445#ent", "pos": [17, 18]}}
{"token": ["HMECs", "expressed", "C0250870#ent", "<e1>", "mRNA", "and", "displayed", "a", "completely", "non-methylated", "C0919445#ent", "<e2>", "with", "an", "open", "chromatin", "structure"], "h": {"id": "C0250870", "name": "C0250870#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919445", "name": "C0919445#ent", "pos": [10, 11]}}
{"token": ["Search", "terms", "included", "heart", "failure", "C0019099#ent", "<e1>", "or", "ventricular", "dysfunction", "heart", "disease", "conjunction", "with", "sexual", "activity", "erectile", "dysfunction", "C0242350#ent", "<e2>", ",", "or", "sex", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242350", "name": "C0242350#ent", "pos": [18, 19]}}
{"token": ["Although", "various", "factors", ",", "such", "as", "myocardial", "infarction", "pressure", "overload", "volume", "overload", "result", "in", "the", "development", "of", "congestive", "heart", "failure", "C0019099#ent", "<e1>", ")", ",", "the", "pathogenesis", "of", "C0242350#ent", "<e2>", "this", "situation", "is", "poorly", "understood", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0242350", "name": "C0242350#ent", "pos": [27, 28]}}
{"token": ["C0040923#ent", "<e1>", "treated", "with", "standard", "courses", "of", "oral", "C0025872#ent", "<e2>", "in", "597", "pregnant", "women"], "h": {"id": "C0040923", "name": "C0040923#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [8, 9]}}
{"token": ["Gossypol", ",", "a", "male", "C0009905#ent", "<e1>", "has", "been", "demonstrated", "to", "have", "C0003392#ent", "<e2>", "and", "antimetastatic", "effects", "many", "kinds", "of", "cancer", "cells", "in", "vitro"], "h": {"id": "C0009905", "name": "C0009905#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [11, 12]}}
{"token": ["Hemolytic", "uremic", "syndrome", "a", "rare", "multisystem", "disorder", "is", "caused", "by", "infections", ",", "preeclampsia", ",", "autoimmune", "disorders", "or", "C0009905#ent", "<e1>", "and", "rarely", "in", "association", "with", "different", "cancers", "and", "C0003392#ent", "<e2>"], "h": {"id": "C0009905", "name": "C0009905#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [27, 28]}}
{"token": ["This", "cleavage", "was", "prevented", "by", "specific", "C1418253#ent", "<e1>", "such", "as", "plasminogen", "activator", "inhibitor", "type-1", "C0085151#ent", "<e2>", "and", "by", "antibodies", "directed", "against", "the", "urokinase", "catalytic", "domain"], "h": {"id": "C1418253", "name": "C1418253#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "C0025677#ent", "<e1>", "could", "cause", "a", "loss", "in", "C0033993#ent", "<e2>", "enhancing", "their", "rate", "of", "cleavage", "to", "folylmonoglutamates", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [9, 10]}}
{"token": ["C0025677#ent", "<e1>", "is", "converted", "to", "C0033993#ent", "<e2>", "polyglutamates", ",", "an", "active", "form", "C0025677#ent", "<e1>", ",", "through", "the", "action", "of", "folylpolyglutamate", "synthetase", "the", "cells", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [5, 6]}}
{"token": ["The", "glutamates", "are", "released", "from", "C0025677#ent", "<e1>", "by", "activity", "of", "the", "C0033993#ent", "<e2>", "GGH", ")", ",", "thereby", "allowing", "the", "efflux", "of", "C0025677#ent", "<e1>", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [11, 12]}}
{"token": ["Further", "evidence", "that", "the", "product", "from", "C0025677#ent", "<e1>", "was", "a", "dipeptide", "came", "from", "C0033993#ent", "<e2>", "quantitative", "amino", "acid", "analysis", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "the", "association", "between", "serum", "C0065661#ent", "<e1>", "levels", "and", "development", "of", "C0243026#ent", "<e2>", "in", "infants", "admitted", "to", "neonatal", "intensive", "care", "units", "NICUs", ")", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}}
{"token": ["Over", "the", "period", "of", "1987", "to", "1989", ",", "three", "hundred", "and", "two", "C1875400#ent", "<e1>", "of", "ten", "species", "of", "mycobacteria", "other", "than", "tuberculosis", "(", "C3273338#ent", "<e2>", ")", "produced", "disease", "in", "282", "patients", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273338", "name": "C3273338#ent", "pos": [23, 24]}}
{"token": ["C1566685#ent", "<e1>", "PP2C", ")", "represent", "a", "diversified", "C1335403#ent", "<e2>", "play", "various", "roles", "in", "cells", "."], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335403", "name": "C1335403#ent", "pos": [7, 8]}}
{"token": ["Chromosomally", "encoded", "Cu2", "+", "P-type", "ATPases", "have", "recently", "been", "recognized", "in", "Enterococcus", "hirae", "these", "are", "closely", "C1512488#ent", "<e1>", "to", "the", "bacterial", "cadmium", "efflux", "C1706373#ent", "<e2>", "and", "the", "human", "copper-deficiency", "disease", "gene", "product", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [23, 24]}}
{"token": ["The", "amino", "acid", "sequence", "NADH", "CoQ", "reductase", "subunit", "IV", "highly", "C1512488#ent", "<e1>", "with", "those", "of", "enzymes", "such", "as", "C1706373#ent", "<e2>", ",", "argininosuccinate", "synthetase", "adenylate", "kinase"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [18, 19]}}
{"token": ["The", "Cd(2+)-efflux", "C1706373#ent", "<e1>", "of", "gram-positive", "bacteria", "a", "large", "P-type", "ATPase", "C1512488#ent", "<e2>", "to", "the", "muscle", "Ca2", "C1706373#ent", "<e1>", "and", "the", "Na+/K+", "ATPases", "animals", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [2, 3]}}
{"token": ["C1705340#ent", "<e1>", ",", "cAMP", "and", "C0256103#ent", "<e2>", "were", "additive", "below", "maximal", "concentrations", ",", "but", "had", "no", "further", "effect", "at", "maximal", "agonist", "concentrations", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [5, 6]}}
{"token": ["Staurosporine", ",", "an", "inhibitor", "of", "protein", "kinase", "C", "resulted", "in", "the", "complete", "inhibition", "of", "C1705340#ent", "<e1>", ",", "cAMP", "and", "C0256103#ent", "<e2>", "action", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [19, 20]}}
{"token": ["All", "the", "three", "breakpoints", ",", "two", "on", "22q12", "and", "one", "in", "1p34", ",", "interrupt", "different", "genes", ":", "C0808901#ent", "<e1>", ",", "ZSG", "and", "C1421373#ent", "<e2>", "."], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1421373", "name": "C1421373#ent", "pos": [22, 23]}}
{"token": ["We", "conclude", "that", "C1419384#ent", "<e1>", "acts", "as", "a", "C0694890#ent", "<e2>", "in", "the", "appropriate", "genetic", "milieu", "and", "signaling", "context", "."], "h": {"id": "C1419384", "name": "C1419384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [8, 9]}}
{"token": ["A", "19-yr-old", "woman", "developed", "a", "C0030486#ent", "<e1>", "with", "a", "C2827387#ent", "<e2>", "at", "22", "weeks", "'", "gestation", "."], "h": {"id": "C0030486", "name": "C0030486#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2827387", "name": "C2827387#ent", "pos": [9, 10]}}
{"token": ["PXR", "concomitantly", "inhibits", "SHP", "C0812327#ent", "<e1>", "maximizes", "the", "PXR", "induction", "of", "the", "C1176140#ent", "<e2>", "human", "livers", "."], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [12, 13]}}
{"token": ["The", "C0017658#ent", "<e1>", "associated", "with", "HCV", "infection", "either", "cryoglobulinemic", "or", "C0473221#ent", "<e2>"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0473221", "name": "C0473221#ent", "pos": [10, 11]}}
{"token": ["A", "mutation", "in", "the", "POU4F3", "gene", "BRN-3.1", ",", "C1418767#ent", "<e1>", ")", "is", "responsible", "for", "C3813718#ent", "<e2>", "(", "MIM", "602459", ")", ",", "autosomal-dominant", "nonsyndromic", "hearing", "loss", "."], "h": {"id": "C1418767", "name": "C1418767#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3813718", "name": "C3813718#ent", "pos": [14, 15]}}
{"token": ["In", "sharp", "contrast", ",", "C1415652#ent", "<e1>", "transcripts", "were", "not", "modulated", "by", "IL-1", "beta", "C0011816#ent", "<e2>", "."], "h": {"id": "C1415652", "name": "C1415652#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [13, 14]}}
{"token": ["ESA1", ",", "SAS3", ",", "MOF", ",", "TIP60", ",", "C1424687#ent", "<e1>", ",", "MOZ", ",", "and", "C2346925#ent", "<e2>", "are", "the", "MYST", "family", "members", "demonstrated", "HAT", "activity", "."], "h": {"id": "C1424687", "name": "C1424687#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2346925", "name": "C2346925#ent", "pos": [14, 15]}}
{"token": ["However", ",", "the", "migration", "rates", "from", "molded", "plates", "containing", "13", "%", "(", "w/w", ")", "C3813197#ent", "<e1>", "were", "almost", "double", "those", "of", "C1418735#ent", "<e2>", "and", "DEHP", "at", "the", "same", "ratios", "."], "h": {"id": "C3813197", "name": "C3813197#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418735", "name": "C1418735#ent", "pos": [21, 22]}}
{"token": ["We", "studied", "C0919457#ent", "<e1>", "methylation", "in", "254", "C1704939#ent", "<e2>", "in", "order", "to", "further", "understand", "the", "clinicopathological", "and", "prognostic", "significance", "C0919457#ent", "<e1>", "methylation", "in", "NSCLC", "."], "h": {"id": "C1704939", "name": "C1704939#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0919457", "name": "C0919457#ent", "pos": [2, 3]}}
{"token": ["Based", "on", "this", "parameter", ",", "CYP3A5", "was", "more", "active", "than", "C1142644#ent", "<e1>", "in", "catalyzing", "total", "C0026056#ent", "<e2>", "hydroxylation", "(", "3-fold", ")", "and", "lidocaine", "demethylation", "(", "1.4-fold", ")", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [10, 11]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [15, 16]}}
{"token": ["A", "C0017337#ent", "<e1>", "encoding", "a", "C0059939#ent", "<e2>", "(", "CBH", ")", "was", "isolated", "from", "Thermoascus", "aurantiacus", "IFO", "9748", "and", "designated", "as", "cbh1", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059939", "name": "C0059939#ent", "pos": [5, 6]}}
{"token": ["A", "C0017337#ent", "<e1>", "(", "cel4", ")", "coding", "for", "a", "C0059939#ent", "<e2>", "Ex-4", ")", "was", "isolated", "from", "the", "white", "rot", "basidiomycete", "Irpex", "lacteus", "strain", "MC-2", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059939", "name": "C0059939#ent", "pos": [9, 10]}}
{"token": ["We", "have", "cloned", "an", "endoglucanase", "(", "EGI", ")", "C0017337#ent", "<e1>", "and", "a", "C0059939#ent", "<e2>", "(", "CBHI", ")", "C0017337#ent", "<e1>", "of", "Humicola", "grisea", "var", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059939", "name": "C0059939#ent", "pos": [12, 13]}}
{"token": ["The", "previously", "isolated", "C0017337#ent", "<e1>", "for", "thermostable", "endo-beta-1,4-glucanase", ",", "C0059939#ent", "<e2>", ",", "and", "beta-glucosidase", "were", "introduced", "into", "the", "chromosome", "of", "K.", "marxianus", "and", "successfully", "expressed", "under", "the", "control", "of", "high-expression", "promoters", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059939", "name": "C0059939#ent", "pos": [9, 10]}}
{"token": ["For", "repressing", "the", "function", "of", "C3853888#ent", "<e1>", "we", "used", "emodin", ",", "a", "C1268567#ent", "<e2>"], "h": {"id": "C3853888", "name": "C3853888#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [12, 13]}}
{"token": ["C1334889#ent", "<e1>", "cleavage", "is", "prevented", "by", "the", "C1516312#ent", "<e2>", "and", "VEID-fmk", "or", "by", "Bcl-2", "expression", "."], "h": {"id": "C1334889", "name": "C1334889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516312", "name": "C1516312#ent", "pos": [7, 8]}}
{"token": ["Only", "a", "few", ",", "if", "any", ",", "C3888088#ent", "<e1>", "from", "the", "aorta", "or", "elastic", "arteries", "the", "systemic", "circulation", "positive", "for", "C1332718#ent", "<e2>", "mRNA", "and", "therefore", "also", "for", "CD97(stalk", ")", "."], "h": {"id": "C3888088", "name": "C3888088#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332718", "name": "C1332718#ent", "pos": [20, 21]}}
{"token": ["As", "expected", ",", "CD97(EGF)-positive", "C3888088#ent", "<e1>", "tumors", "expressed", "partly", "N-glycosylated", "C1332718#ent", "<e2>", "."], "h": {"id": "C3888088", "name": "C3888088#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332718", "name": "C1332718#ent", "pos": [10, 11]}}
{"token": ["Categorized", "by", "disease", ",", "there", "were", "14", "cases", "of", "colitis", ",", "9", "cases", "of", "C0023885#ent", "<e1>", "4", "cases", "of", "colitis", "with", "C0023885#ent", "<e1>", "and", "1", "case", "of", "C0023885#ent", "<e1>", "C1510428#ent", "<e1>"], "h": {"id": "C0023885", "name": "C0023885#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1510428", "name": "C1510428#ent", "pos": [29, 30]}}
{"token": ["The", "response", "rate", "C1332701#ent", "<e1>", "tumour-bearing", "rats", "when", "C0812246#ent", "<e2>", "was", "coadministrated", "with", "melphalan", "was", "strongly", "correlated", "with", "drug", "accumulation", "tumour", "tissue", "as", "only", "in", "these", "rats", "a", "five-fold", "increased", "melphalan", "concentration", "was", "observed", "."], "h": {"id": "C1332701", "name": "C1332701#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [8, 9]}}
{"token": ["Five", "of", "the", "patients", "had", "never", "taken", "anticholinesterase", "drugs", "for", "diagnostic", "injections", "C0013615#ent", "<e1>", "while", "the", "other", "two", "patients", "had", "been", "treated", "with", "oral", "preparations", "C3540726#ent", "<e2>", "."], "h": {"id": "C0013615", "name": "C0013615#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540726", "name": "C3540726#ent", "pos": [25, 26]}}
{"token": ["This", "is", "also", "demonstrated", "by", "the", "rescue", "of", "Drosophila", "C0914122#ent", "<e1>", "-", "9", "mutant", "phenotypes", "with", "human", "C1420532#ent", "<e2>", "transgenes", "."], "h": {"id": "C0914122", "name": "C0914122#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420532", "name": "C1420532#ent", "pos": [17, 18]}}
{"token": ["For", "example", ",", "C3273437#ent", "<e1>", "increases", "the", "expression", "of", "the", "C0812327#ent", "<e2>", "and", "increases", "abundance", "and", "phosphorylation", "of", "c-Jun", "protein"], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [10, 11]}}
{"token": ["C3273437#ent", "<e1>", "is", "a", "member", "of", "the", "C0812327#ent", "<e2>", "its", "rat", "homologue", "Pet-1", "and", "the", "human", "homologue", "FEV", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [7, 8]}}
{"token": ["The", "concomitance", "of", "mitral", "and", "C0040961#ent", "<e1>", "noteworthy", ",", "since", "mitral", "regurgitation", "produce", "C0023212#ent", "<e2>", "mask", "tricuspid", "valve", "disease"], "h": {"id": "C0040961", "name": "C0040961#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023212", "name": "C0023212#ent", "pos": [13, 14]}}
{"token": ["During", "tests", "of", "antagonism", ",", "neither", "mesulergine", ",", "the", "nonspecific", "C0036753#ent", "<e1>", "the", "5-HT2", "antagonist", "ketanserin", "the", "C0162756#ent", "<e2>", "ICS", "205", "-", "930", ")", ",", "nor", "(+/-)-pindolol", "and", "(+/-)-propranolol", "attenuated", "the", "stimulus", "effect", "eltoprazine", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162756", "name": "C0162756#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "we", "hypothesized", "that", "mutations", "in", "the", "EGR2-interacting", "domains", "of", "NAB1", "and", "C1417589#ent", "<e1>", "might", "be", "associated", "with", "pathogenesis", "of", "inherited", "C0031117#ent", "<e2>", "currently", "unexplained", "cases", "."], "h": {"id": "C1417589", "name": "C1417589#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [22, 23]}}
{"token": ["In", "vitro", "rimantadine", "hydrochloride", "similar", "in", "activity", "to", "C0771734#ent", "<e1>", "ribavirin", ",", "but", "C0056788#ent", "<e2>", "was", "considerably", "less", "active", "."], "h": {"id": "C0771734", "name": "C0771734#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0056788", "name": "C0056788#ent", "pos": [13, 14]}}
{"token": ["Overexpression", "of", "all", "membrane", "type", "matrix", "metalloproteases", "C1568288#ent", "<e1>", ")", "described", "to", "date", "indicates", "that", "MT1-MMP", "and", "C1417205#ent", "<e2>", "are", "endowed", "with", "ability", "to", "generate", "sBG-90", "."], "h": {"id": "C1568288", "name": "C1568288#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417205", "name": "C1417205#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "C0001640#ent", "<e1>", "prazosin", "and", "thymoxamine", ",", "and", "the", "alpha", "2-adrenoceptor", "antagonists", "C0242546#ent", "<e2>", "and", "yohimbine", ",", "on", "these", "responses", "were", "studied", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242546", "name": "C0242546#ent", "pos": [14, 15]}}
{"token": ["Marked", "differences", "in", "affinity", "of", "particular", "C0001640#ent", "<e1>", "observed", "for", "alpha", "2-adrenoceptors", "by", "C0242546#ent", "<e2>", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242546", "name": "C0242546#ent", "pos": [13, 14]}}
{"token": ["Clonidine", "was", "used", "as", "an", "C0001640#ent", "<e1>", "and", "yohimbine", "and", "C0242546#ent", "<e2>", "were", "used", "as", "antagonists", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242546", "name": "C0242546#ent", "pos": [10, 11]}}
{"token": ["C0754647#ent", "<e1>", "could", "make", "its", "mark", "especially", "in", "slowly", "progressing", "C0149931#ent", "<e2>", "attacks", "and", "in", "attacks", "that", "are", "highly", "predictable", "."], "h": {"id": "C0754647", "name": "C0754647#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [10, 11]}}
{"token": ["C0769345#ent", "<e1>", "hemagglutinin", "activities", "Porphyromonas", "gingivalis", "been", "implicated", "as", "virulence", "factors", "C0031099#ent", "<e2>", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031099", "name": "C0031099#ent", "pos": [11, 12]}}
{"token": ["During", "embryogenesis", ",", "Pur", "alpha", "expressed", "widely", ",", "whereas", "C1336848#ent", "<e1>", "has", "an", "overlapping", "pattern", "of", "expression", "with", "C1414993#ent", "<e2>", "in", "the", "nervous", "system"], "h": {"id": "C1336848", "name": "C1336848#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414993", "name": "C1414993#ent", "pos": [18, 19]}}
{"token": ["In", "this", "report", ",", "we", "describe", "the", "identification", "of", "zebrafish", "Pur", "alpha", "C1336848#ent", "<e1>", "orthologs", "as", "two", "factors", "that", "function", "to", "regulate", "neuronal", "expression", "C1414993#ent", "<e2>", "."], "h": {"id": "C1336848", "name": "C1336848#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414993", "name": "C1414993#ent", "pos": [24, 25]}}
{"token": ["In", "addition", "to", "C1426312#ent", "<e1>", ",", "we", "have", "identified", "a", "novel", "aflatoxin-aldehyde", "reductase", "C1704941#ent", "<e2>", ")", "that", "is", "similarly", "induced", "by", "ethoxyquin", "."], "h": {"id": "C1426312", "name": "C1426312#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704941", "name": "C1704941#ent", "pos": [13, 14]}}
{"token": ["130", "fungal", "and", "50", "actinomycete", "strains", "similarly", "tested", "for", "the", "production", "of", "extracellular", "inhibitors", "C3853636#ent", "<e1>", "DHFR", ")", "and", "alkaline", "phosphatase", "C1705550#ent", "<e2>", ")", "."], "h": {"id": "C3853636", "name": "C3853636#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705550", "name": "C1705550#ent", "pos": [21, 22]}}
{"token": ["The", "pathogenesis", "of", "intolerance", "is", "still", "unclear", ":", "immune-mediated", "reactions", "been", "reported", "following", "the", "use", "of", "C3540780#ent", "<e1>", ",", "less", "commonly", "C0004057#ent", "<e2>", ",", "anthranilic-acid", "derivatives", "and", "diclofenac", "."], "h": {"id": "C3540780", "name": "C3540780#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [21, 22]}}
{"token": ["Activities", "of", "leucylaminopeptidase", ",", "C0052527#ent", "<e1>", "gamma-glutamyl", "transpeptidase", "oxytocinase", ",", "phosphohexoisomerase", ",", "C0162449#ent", "<e2>", "and", "aldolase", "were", "studied", "in", "amniotic", "cells", "cases", "of", "pregnancy", "complicated", "by", "threatening", "intrauterine", "fetal", "asphyxia"], "h": {"id": "C0052527", "name": "C0052527#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162449", "name": "C0162449#ent", "pos": [12, 13]}}
{"token": ["C3274668#ent", "<e1>", ",", "which", "fuses", "the", "DNA-binding", "domain", "AML1", "to", "most", "of", "C1424490#ent", "<e2>", ",", "represses", "the", "transcriptional", "activity", "both", "CBF", "and", "GATA1", "."], "h": {"id": "C3274668", "name": "C3274668#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1424490", "name": "C1424490#ent", "pos": [12, 13]}}
{"token": ["Intrastriatal", "GABA", "decreased", "seizure", "activity", "not", "the", "biting", ",", "whilst", "RS86", ",", "C0009011#ent", "<e1>", ",", "oxiperomide", "and", "tiapride", "decreased", "biting", "and", "C0036572#ent", "<e2>", "."], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [21, 22]}}
{"token": ["The", "protective", "effect", "two", "benzodiazepine", "compounds", "diazepam", "and", "C0009011#ent", "<e1>", "was", "tested", "against", "isoniazid", "(INH)-", "induced", "C0036572#ent", "<e2>", "in", "rats", "pretreated", "with", "the", "gamma-amino-butyric", "acid", "GABA", ")", "transaminase", "inhibitor", ".", ","], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [16, 17]}}
{"token": ["The", "C0003391#ent", "<e1>", "mechanism", "of", "a", "23-mer", "antimicrobial", "peptide", "C0252800#ent", "<e2>", ",", "derived", "from", "pig", "myeloid", "investigated", "."], "h": {"id": "C0003391", "name": "C0003391#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0252800", "name": "C0252800#ent", "pos": [9, 10]}}
{"token": ["This", "is", "the", "second", "known", "case", "report", "C1420232#ent", "<e1>", "with", "histopathologic", "features", "of", "C0034155#ent", "<e2>", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034155", "name": "C0034155#ent", "pos": [13, 14]}}
{"token": ["Cytogenetic", "analysis", "a", "47,XX,+r", "karyotype", "in", "50", "%", "of", "the", "cells", ",", "and", "molecular", "investigation", "disclosed", "the", "presence", "of", "a", "transcript", "fusing", "C1704810#ent", "<e1>", "exon", "37", "to", "C0751995#ent", "<e2>", "exon", "2"], "h": {"id": "C1704810", "name": "C1704810#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0751995", "name": "C0751995#ent", "pos": [27, 28]}}
{"token": ["Interestingly", ",", "a", "significant", "fraction", "(", "13", "-", "62", "%", ")", "of", "the", "total", "C1413903#ent", "<e1>", "activity", "was", "recovered", "in", "its", "C0003589#ent", "<e2>", "form", ",", "the", "percentage", "depending", "on", "the", "culture", "conditions"], "h": {"id": "C1413903", "name": "C1413903#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003589", "name": "C0003589#ent", "pos": [21, 22]}}
{"token": ["A", "classical", "guitarist", "performing", "for", "at", "least", "5", "hours", "each", "day", "developed", "a", "C0343180#ent", "<e1>", "the", "left", "wrist", "joint", "was", "first", "erroneously", "considered", "to", "be", "C0038013#ent", "<e2>"], "h": {"id": "C0343180", "name": "C0343180#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [25, 26]}}
{"token": ["Like", "other", "GHRPs", ",", "C1415537#ent", "<e1>", "possesses", "also", "C1418938#ent", "<e2>", "(", "PRL", ")", "and", "ACTH/cortisol-releasing", "activity", "."], "h": {"id": "C1415537", "name": "C1415537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [8, 9]}}
{"token": ["Like", "other", "GHRPs", ",", "C1415537#ent", "<e1>", "possesses", "also", "prolactin", "(", "C1418938#ent", "<e2>", ")", "and", "ACTH/cortisol-releasing", "activity", "."], "h": {"id": "C1415537", "name": "C1415537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [10, 11]}}
{"token": ["Neither", "intranasal", "nor", "oral", "C1415537#ent", "<e1>", "treatment", "modified", "C1418938#ent", "<e2>", "or", "cortisol", "levels", "did", "not", "induce", "any", "side", "effect"], "h": {"id": "C1415537", "name": "C1415537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [8, 9]}}
{"token": ["C0027813#ent", "<e1>", "more", "common", "in", "patients", "with", "C0009324#ent", "<e2>", "than", "CD", "."], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [7, 8]}}
{"token": ["There", "is", "a", "link", "between", "gut", "and", "spondyloarthropathies", ",", "which", "extends", "from", "the", "acute", "ReA", "by", "enteritis", "due", "to", "gram-negative", "bacteria", "ankylosing", "spondylitis", "C0027813#ent", "<e1>", "association", "with", "Crohn's", "disease", "C0009324#ent", "<e2>"], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [29, 30]}}
{"token": ["Peripheral", "neuropathy", "C0027813#ent", "<e1>", "may", "be", "an", "immunologically", "mediated", "extraintestinal", "manifestation", "C0009324#ent", "<e2>"], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [11, 12]}}
{"token": ["The", "C0669365#ent", "<e1>", "chemokines", "TARC", ",", "C1705076#ent", "<e2>", "and", "PARC", "were", "expressed", "in", "immature", "DC", "and", "were", "up-regulated", "following", "maturation", ",", "while", "ELC", "was", "produced", "only", "at", "late", "time", "points"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705076", "name": "C1705076#ent", "pos": [6, 7]}}
{"token": ["By", "a", "yeast", "two-hybrid", "system", "ribosomal", "phosphoproteins", "P0", "and", "C3273601#ent", "<e1>", "and", "a", "putative", "mitotic", "checkpoint", "protein", "C1416960#ent", "<e2>", ",", "were", "found", "to", "interact", "with", "an", "active-site", "mutated", "trichosanthin", "(", "TCS", ")", "."], "h": {"id": "C3273601", "name": "C3273601#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416960", "name": "C1416960#ent", "pos": [17, 18]}}
{"token": ["C0538927#ent", "<e1>", "attenuated", "the", "likelihood", "of", "developing", "spontaneous", "recurrent", "seizures", "after", "C0031923#ent", "<e2>", "prolonged", "seizure", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031923", "name": "C0031923#ent", "pos": [11, 12]}}
{"token": ["Analysis", "indicated", "that", "women", "smoked", "tobacco", "cannabis", "and", "C2827557#ent", "<e1>", "less", "than", "men", ",", "while", "women", "took", "more", "C0304402#ent", "<e2>", "and", "other", "opiate", "type", "drugs", "than", "men", "."], "h": {"id": "C2827557", "name": "C2827557#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "the", "C0037285#ent", "<e1>", "be", "controlled", "effectively", "with", "the", "administration", "of", "C0009262#ent", "<e2>", ",", "nonsteroidal", "anti-inflammatory", "agents", "intra-articular", "corticosteroid", "injections", "."], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [12, 13]}}
{"token": ["A", "44", "year", "old", "woman", "presented", "with", "C0221759#ent", "<e1>", "an", "isolated", "C0015469#ent", "<e2>"], "h": {"id": "C0221759", "name": "C0221759#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015469", "name": "C0015469#ent", "pos": [11, 12]}}
{"token": ["A", "randomized", ",", "double-blind", ",", "placebo-controlled", "trial", "C0700580#ent", "<e1>", "nasal", "spray", "performed", "with", "25", "patients", "with", "C0035460#ent", "<e2>"], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0035460", "name": "C0035460#ent", "pos": [16, 17]}}
{"token": ["C0700580#ent", "<e1>", "seems", "to", "have", "a", "beneficial", "effect", "on", "C0035460#ent", "<e2>", "which", "often", "is", "an", "irritating", "condition", "in", "elderly", "patients", "."], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0035460", "name": "C0035460#ent", "pos": [9, 10]}}
{"token": ["Cortical", "and", "supranuclear", "cataract", "less", "common", "and", "severe", "in", "the", "C0206368#ent", "<e1>", "while", "the", "reverse", "is", "true", "for", "C0392557#ent", "<e2>"], "h": {"id": "C0206368", "name": "C0206368#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0392557", "name": "C0392557#ent", "pos": [18, 19]}}
{"token": ["In", "cells", "lacking", "C1415408#ent", "<e1>", ",", "recruitment", "of", "RNA", "polymerase", "II", "TATA-binding", "protein", "the", "C3538683#ent", "<e2>", "-", "10", "promoters", "is", "significantly", "diminished", "under", "inducing", "conditions", "."], "h": {"id": "C1415408", "name": "C1415408#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538683", "name": "C3538683#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "we", "have", "shown", "that", "C1415408#ent", "<e1>", "can", "regulate", "nucleosome", "positioning", "the", "C3538683#ent", "<e2>", "promoter", "."], "h": {"id": "C1415408", "name": "C1415408#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3538683", "name": "C3538683#ent", "pos": [13, 14]}}
{"token": ["Hepatic", "P450", "enzyme", "activities", "C0171552#ent", "<e1>", ",", "EROD", ",", "PROD", ",", "BROD", ",", "and", "C0002586#ent", "<e2>", ")", "were", "increased", "significantly", "by", "fish", "diets", "both", "sources", "."], "h": {"id": "C0171552", "name": "C0171552#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002586", "name": "C0002586#ent", "pos": [14, 15]}}
{"token": ["The", "therapeutic", "monitoring", "of", "trough", "blood", "concentrations", "C1425411#ent", "<e1>", ",", "as", "with", "C0751039#ent", "<e2>", ",", "may", "be", "useful", "in", "guiding", "dosage", "adjustments", "maximize", "the", "immunosuppressive", "efficacy", "minimizing", "drug-induced", "side-effects", "."], "h": {"id": "C1425411", "name": "C1425411#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [12, 13]}}
{"token": ["Allografts", "received", "a", "single", "C1425411#ent", "<e1>", "dose", "of", "(", "1.5", "mg/kg", ")", "combined", "with", "C0751039#ent", "<e2>", "(", "10", "mg/kg", ")", "12", "-", "14", "hr", "prior", "to", "transplantation", "."], "h": {"id": "C1425411", "name": "C1425411#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [14, 15]}}
{"token": ["C0221757#ent", "<e1>", "subjects", "to", "developing", "C0034067#ent", "<e2>", "childhood", "liver", "cirrhosis"], "h": {"id": "C0221757", "name": "C0221757#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0034067", "name": "C0034067#ent", "pos": [5, 6]}}
{"token": ["Furthermore", ",", "ectopic", "expression", "of", "C1608529#ent", "<e1>", "in", "hepatoma", "cells", "adenoviral", "infection", "increased", "the", "expression", "of", "C0031644#ent", "<e2>", "and", "G6Pase", "genes", "and", "led", "to", "elevated", "glucose", "production"], "h": {"id": "C1608529", "name": "C1608529#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [16, 17]}}
{"token": ["During", "conservative", "treatment", "the", "C0033568#ent", "<e1>", "PGE(2)", "and", "dinoprost", "(", "PGF(2alpha", ")", ")", ",", "C0034063#ent", "<e2>", "cardiac", "decompensation", "and", ",", "subsequently", ",", "the", "patient", "suffered", "cardiopulmonary", "arrest"], "h": {"id": "C0033568", "name": "C0033568#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [14, 15]}}
{"token": ["The", "investigation", "of", "gas", "exchange", "central", "hemodynamics", "real", "oxygen", "transport", "shown", "expediency", "of", "using", "C0014996#ent", "<e1>", "and", "fluothane", "as", "main", "C0017302#ent", "<e2>", "operations", "on", "the", "lungs", "in", "patients", "with", "a", "compensated", "form", "of", "chronic", "pulmonary", "respiratory", "insufficiency"], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017302", "name": "C0017302#ent", "pos": [20, 21]}}
{"token": ["Phase", "I", "to", "analyse", "the", "effect", "of", "C0014996#ent", "<e1>", "and", "isoflurane", "as", "C0017302#ent", "<e2>"], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017302", "name": "C0017302#ent", "pos": [12, 13]}}
{"token": ["We", "recently", "reported", "that", "PAHs", "down-regulated", "the", "liver", "X", "receptor", "LXR", ")", "alpha-regulated", "genes", "via", "aryl", "hydrocarbon", "receptor", "C1706481#ent", "<e1>", ")", "as", "one", "of", "the", "causes", "responsible", "for", "C0003850#ent", "<e2>", "induced", "by", "PAHs", "."], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [28, 29]}}
{"token": ["These", "findings", "suggest", "that", "activation", "of", "the", "C1706481#ent", "<e1>", "can", "be", "an", "underlying", "mechanism", "of", "C0003850#ent", "<e2>", "mediated", "by", "certain", "environmental", "contaminants"], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [15, 16]}}
{"token": ["In", "spite", "of", "its", "strong", "effect", "on", "C1522428#ent", "<e1>", "mRNA", "accumulation", ",", "the", "C0001644#ent", "<e2>", "not", "enhance", "C1522428#ent", "<e1>", "activity", "produced", "by", "microglial", "cells"], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "the", "C1416706#ent", "<e1>", "for", "(-)-GCg", "could", "be", "successfully", "used", "for", "C1875400#ent", "<e2>", "(-)-EGCg", "and", "-ECg", "from", "green", "tea", "extract"], "h": {"id": "C1416706", "name": "C1416706#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}}
{"token": ["Topical", "treatments", "of", "emollients", "and", "keratolytic", "agents", "anthralin", ",", "coal", "tar", "C3540725#ent", "<e1>", ",", "vitamin", "D3", "analogues", ",", "topical", "retinoids", "and", "C0033858#ent", "<e2>", "ultraviolet", "A", "UVA", ")", "light", "."], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033858", "name": "C0033858#ent", "pos": [21, 22]}}
{"token": ["Dextropropoxyphene", "(", "C0012582#ent", "<e1>", ")", "is", "a", "commonly", "used", "C0456386#ent", "<e2>", "for", "suicide", "attempts", "Denmark", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0456386", "name": "C0456386#ent", "pos": [9, 10]}}
{"token": ["The", "target", "of", "inhibition", "is", "not", "C0012863#ent", "<e1>", "this", "energy-independent", "assembly", "system", "lacks", "any", "ATP", "and", "C1417500#ent", "<e2>", "+", "-dependent", "type", "II", "topoisomerase", "gyrase", "activities"], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [16, 17]}}
{"token": ["Our", "findings", "indicate", "that", "combination", "peginterferon", "and", "ribavirin", "therapy", "may", "be", "as", "effective", "in", "treating", "C0400914#ent", "<e1>", "it", "is", "in", "C0019189#ent", "<e2>"], "h": {"id": "C0400914", "name": "C0400914#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019189", "name": "C0019189#ent", "pos": [20, 21]}}
{"token": ["C3273338#ent", "<e1>", "follicle", "culture", "media", "analysed", "for", "glucose", ",", "C0376261#ent", "<e2>", "and", "pyruvate", "concentrations", "."], "h": {"id": "C3273338", "name": "C3273338#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [9, 10]}}
{"token": ["The", "conformational", "change", "be", "substituted", "by", "cleavage", "between", "domain", "D1", "C1414052#ent", "<e1>", ",", "in", "an", "area", "that", "can", "be", "cleaved", "by", "C0042071#ent", "<e2>", "itself", "at", "high", "efficiency", "."], "h": {"id": "C1414052", "name": "C1414052#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [21, 22]}}
{"token": ["We", "demonstrated", "first", "that", "IE63", "was", "phosphorylated", "on", "Ser-224", "in", "vitro", "C1332721#ent", "<e1>", "and", "CDK5", "but", "not", "by", "CDK2", ",", "C0255652#ent", "<e2>", ",", "or", "CDK9", "."], "h": {"id": "C1332721", "name": "C1332721#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0255652", "name": "C0255652#ent", "pos": [20, 21]}}
{"token": ["C0255652#ent", "<e1>", "phosphorylates", "C1332721#ent", "<e2>", ",", "Cdk2", ",", "Cdk4", ",", "and", "Cdk6", ",", "but", "only", "C1332721#ent", "<e2>", "and", "Cdk2", "can", "phosphorylate", "C0255652#ent", "<e1>", "and", "none", "of", "them", "is", "able", "to", "auto-phosphorylate", "."], "h": {"id": "C1332721", "name": "C1332721#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0255652", "name": "C0255652#ent", "pos": [0, 1]}}
{"token": ["It", "has", "been", "suggested", "that", "this", "stimulus-produced", "hypotension", "(", "SPH", ")", "may", "be", "mediated", "by", "direct", "C1418482#ent", "<e1>", "projections", "to", "either", "the", "posterolateral", "hypothalamus", "the", "nucleus", "tractus", "solitarius", "C1417869#ent", "<e2>", ")", "."], "h": {"id": "C1418482", "name": "C1418482#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [28, 29]}}
{"token": ["However", ",", "these", "findings", "do", "not", "support", "the", "hypothesis", "that", "prefrontal", "SPH", "mediated", "by", "direct", "projections", "from", "the", "C1418482#ent", "<e1>", "to", "the", "C1417869#ent", "<e2>", "."], "h": {"id": "C1418482", "name": "C1418482#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [22, 23]}}
{"token": ["Cytokines", "are", "involved", "in", "the", "symptoms", "of", "the", "acute", "phase", "response", "induced", "by", "C0009450#ent", "<e1>", "humans", "as", "well", "as", "in", "animals", ",", "and", "C1522428#ent", "<e2>", "IL-1", "beta", "has", "a", "pivotal", "role", "in", "these", "changes", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "that", "C0754775#ent", "<e1>", "may", "have", "therapeutic", "potential", "for", "the", "treatment", "of", "C0162819#ent", "<e2>", "as", "restenosis", "and", "atherosclerosis", "."], "h": {"id": "C0754775", "name": "C0754775#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162819", "name": "C0162819#ent", "pos": [14, 15]}}
{"token": ["Using", "this", "approach", ",", "we", "identify", "three", "C0017337#ent", "<e1>", "whose", "expression", "is", "activated", "by", "proviral", "integration", "in", "BXH-2", "leukaemias", "C1415661#ent", "<e2>", ",", "Hoxa9", ",", "and", "a", "Pbx1-related", "homeobox", "gene", ",", "Meis1", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415661", "name": "C1415661#ent", "pos": [19, 20]}}
{"token": ["High", "labelling", "indices", "(", "LI", ")", "were", "found", "in", "C0025297#ent", "<e1>", "up", "to", "8", "per", "cent", ")", "and", "C0034544#ent", "<e2>", "(", "up", "to", "6", "per", "cent", ")", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034544", "name": "C0034544#ent", "pos": [18, 19]}}
{"token": ["The", "neurologic", "abnormalities", "C0025297#ent", "<e1>", "encephalitis", ",", "cranial", "neuritis", "motor", "and", "C0034544#ent", "<e2>", "and", "myelitis", "in", "various", "combinations", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034544", "name": "C0034544#ent", "pos": [11, 12]}}
{"token": ["In", "humans", ",", "functionally", "relevant", "polymorphisms", ",", "which", "may", "significantly", "modulate", "epoxyeicosatrienoic", "acid", "in", "vivo", "have", "been", "identified", "in", "the", "genes", "encoding", "C1413880#ent", "<e1>", ",", "CYP2C8", ",", "CYP2C9", "and", "soluble", "C0014628#ent", "<e2>"], "h": {"id": "C1413880", "name": "C1413880#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0014628", "name": "C0014628#ent", "pos": [30, 31]}}
{"token": ["GLUT4", "mRNA", "levels", "decreased", "with", "C0475718#ent", "<e1>", "and", "recovered", "only", "partially", "with", "correction", "of", "C0020456#ent", "<e2>", "."], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [14, 15]}}
{"token": ["It", "may", "be", "easier", "to", "influence", "fasting", "C0475718#ent", "<e1>", "by", "GLP-1", "than", "to", "reduce", "meal-related", "increments", "in", "C0020456#ent", "<e2>", "."], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [17, 18]}}
{"token": ["Currently", "used", "oral", "antidiabetic", "agents", "as", "sulphonylureas", ",", "biguanides", "(", "metformin", ")", "and", "the", "thiazolidinediones", "(", "rosiglitazone", ",", "pioglitazone", ")", "commonly", "target", "fasting", "C0475718#ent", "<e1>", "and", "have", "limited", "additive", "effects", "postprandial", "C0020456#ent", "<e2>", "."], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [23, 24]}, "relation": "has_nichd_parent", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [31, 32]}}
{"token": ["Many", "authors", "demonstrate", "statistically", "more", "significant", "correlations", "between", "postprandial", "C0475718#ent", "<e1>", "and", "HbA1c", "levels", ",", "compared", "to", "correlation", "of", "fasting", "C0020456#ent", "<e2>", "."], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [20, 21]}}
{"token": ["C1333570#ent", "<e1>", "values", "were", "elevated", "in", "both", "D1", "and", "C1414052#ent", "<e2>", "but", "not", "in", "a", "linear", "fashion", "as", "observed", "with", "PSA", "."], "h": {"id": "C1333570", "name": "C1333570#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [9, 10]}}
{"token": ["The", "number", "of", "cells", "expressing", "C1423638#ent", "<e1>", ",", "gustducin", ",", "Mash1", "and", "C1413784#ent", "<e2>", "gradually", "decreased", "after", "denervation", "."], "h": {"id": "C1423638", "name": "C1423638#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413784", "name": "C1413784#ent", "pos": [12, 13]}}
{"token": ["C0041236#ent", "<e1>", "and", "SLIGRL-NH(2", ")", "relaxed", "isolated", "trachea", "and", "main", "C0006267#ent", "<e2>", ",", "and", "contracted", "intrapulmonary", "bronchi"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [10, 11]}}
{"token": ["Rat", "C1539921#ent", "<e1>", "may", "affect", "microtubule", "or", "C1334752#ent", "<e2>", "thereby", "regulating", "the", "neuroplastic", "changes", "associated", "with", "development", "of", "alcohol", "dependence", "physical", "withdrawal", "."], "h": {"id": "C1539921", "name": "C1539921#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334752", "name": "C1334752#ent", "pos": [7, 8]}}
{"token": ["The", "up-regulation", "of", "BSEP", "expression", "by", "guggulsterone", "without", "activating", "FXR", "pathway", "as", "an", "FXR", "C2987634#ent", "<e1>", "to", "suppress", "C1413893#ent", "<e2>", "expression", "represents", "a", "possible", "mechanism", "for", "guggulsterone-mediated", "hypolipidemic", "effect", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413893", "name": "C1413893#ent", "pos": [18, 19]}}
{"token": ["The", "biguanide", ",", "C0025598#ent", "<e1>", ",", "is", "widely", "used", "for", "the", "treatment", "of", "C0011860#ent", "<e2>"], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [13, 14]}}
{"token": ["C0025598#ent", "<e1>", "offers", "a", "useful", "treatment", "for", "insulin-resistant", "overweight", "C0011860#ent", "<e2>", "patients", "."], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "C1412761#ent", "<e1>", "is", "a", "cluster", "gene", "coding", "a", "multifunctional", "protein", "both", "acetyl-CoA", "carboxylase", "C0014442#ent", "<e2>", "activities", "on", "the", "same", "polypeptide", "chain"], "h": {"id": "C1412761", "name": "C1412761#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Mice", "deficient", "in", "C1412761#ent", "<e1>", "have", "continuous", "fatty", "acid", "oxidation", "reduced", "body", "fat", "body", "weight", "validating", "this", "C0014442#ent", "<e2>", "as", "a", "target", "for", "drug", "development", "obesity", ",", "diabetes", "and", "other", "symptoms", "of", "the", "metabolic", "syndrome"], "h": {"id": "C1412761", "name": "C1412761#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["However", ",", "the", "prevalence", "and", "severity", "of", "C0020625#ent", "<e1>", "and", "hypercreatininemia", "in", "C0271801#ent", "<e2>", "patients", "without", "comorbid", "conditions", "not", "been", "well", "documented", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0271801", "name": "C0271801#ent", "pos": [12, 13]}}
{"token": ["A", "disturbed", "metabolism", "of", "glucocorticoid", "may", "have", "been", "responsible", "for", "the", "C0020625#ent", "<e1>", "and", "disturbance", "in", "plasma", "vasopressin", "regulation", "in", "this", "C0271801#ent", "<e2>", "patient", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0271801", "name": "C0271801#ent", "pos": [21, 22]}}
{"token": ["Two", "children", "with", "fungal", "C0042029#ent", "<e1>", "UTI", ")", "were", "treated", "with", "C0016277#ent", "<e2>", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [11, 12]}}
{"token": ["C0027126#ent", "<e1>", "dystrophia", "myotonica", "DM", ")", "is", "a", "clinical", "syndrome", "includes", "myotonic", "dystrophy", "type", "1", "C3250443#ent", "<e2>", ")", ",", "myotonic", "dystrophy", "type", "2", "DM2", ")", ",", "myotonic", "dystrophy", "type", "3", "DM3", ")", ",", "and", "so", "forth", "."], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C3250443", "name": "C3250443#ent", "pos": [15, 16]}}
{"token": ["C0010674#ent", "<e1>", "patients", "also", "require", "hepatobiliary", "scintigraphy", "liver", "and", "C0005424#ent", "<e2>", "really", "occur", "independently", "of", "the", "underlying", "disease", "severity", "the", "presence", "of", "steatorrhea", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005424", "name": "C0005424#ent", "pos": [9, 10]}}
{"token": ["Three", "large", "placebo-controlled", "clinical", "trials", "more", "than", "9000", "patients", "have", "shown", "that", "carvedilol", ",", "C0053799#ent", "<e1>", "and", "metoprolol", "significantly", "reduce", "morbidity", "and", "mortality", "in", "C0018801#ent", "<e2>"], "h": {"id": "C0053799", "name": "C0053799#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [24, 25]}}
{"token": ["Moreover", ",", "EGCG", "inhibited", "C0812228#ent", "<e1>", "phosphorylation", "as", "well", "as", "TNF", "activation", "of", "C1363984#ent", "<e2>", ",", "which", "subsequently", "resulted", "in", "reduced", "MCP-1", "production", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1363984", "name": "C1363984#ent", "pos": [13, 14]}}
{"token": ["Interaction", "of", "C1436312#ent", "<e1>", "BB", "and", "C1738886#ent", "<e2>", "null", "genotypes", "modulated", "risk", "(", "OR", ",", "2.3", ";", "95", "%", "CI", ",", "1.1", "-", "3.7", ";", "P", "=", "0.01", ")", "."], "h": {"id": "C1436312", "name": "C1436312#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1738886", "name": "C1738886#ent", "pos": [6, 7]}}
{"token": ["The", "genes", "C0812313#ent", "<e1>", ",", "Jund1", ",", "Mel", ",", "and", "C1424525#ent", "<e2>", "are", "discussed", "as", "possible", "candidates", "for", "Cat4", "."], "h": {"id": "C0812313", "name": "C0812313#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424525", "name": "C1424525#ent", "pos": [10, 11]}}
{"token": ["Mutations", "inactivating", "components", "of", "the", "Skp1/cullin/", "F-box", "(", "C1366480#ent", "<e1>", ")", "ubiquitin", "ligase", "complex", "Skp1", "and", "the", "F-box", "protein", "stabilize", "C2984133#ent", "<e2>", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2984133", "name": "C2984133#ent", "pos": [20, 21]}}
{"token": ["Other", "dermatoses", "included", "lymphedema", ",", "invasive", "squamous", "cell", "carcinoma", "tinea", "cruris", "psoriasis", ",", "furuncle", ",", "folliculitis", ",", "C0023646#ent", "<e1>", "epidermal", "inclusion", "cyst", "herpes", "zoster", "irritant", "contact", "dermatitis", "acrochordon", ",", "Bartholin", "cyst", "fibroepithelial", "stromal", "polyp", "C0026393#ent", "<e2>", "autoinoculated", ")", ",", "and", "streptococcal", "vulvitis"], "h": {"id": "C0023646", "name": "C0023646#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0026393", "name": "C0026393#ent", "pos": [34, 35]}}
{"token": ["CAVHD", "offers", "technical", "advantages", "over", "alternative", "therapy", "providing", "equivalent", "or", "better", "biochemical", "control", "C0242528#ent", "<e1>", "and", "volume", "status", "critically", "ill", "patients", "with", "C3854173#ent", "<e2>"], "h": {"id": "C0242528", "name": "C0242528#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [22, 23]}}
{"token": ["Nephrotoxicity", ",", "in", "the", "form", "of", "transient", "proteinuria", "C0242528#ent", "<e1>", ",", "abnormalities", "of", "tubular", "function", "and", "C3854173#ent", "<e2>", "is", "the", "major", "toxic", "condition", "administration", "of", "streptozotocin", "."], "h": {"id": "C0242528", "name": "C0242528#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [16, 17]}}
{"token": ["In", "the", "POU", "region", "murine", "C1332801#ent", "<e1>", "differs", "in", "four", "C3539946#ent", "<e2>", "the", "human", "homologue", "and", "these", "differences", "are", "restricted", "to", "helices", "1", "and", "2", "."], "h": {"id": "C1332801", "name": "C1332801#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [10, 11]}}
{"token": ["C1332801#ent", "<e1>", "have", "more", "than", "the", "last", "14", "C3539946#ent", "<e2>", "removed", "are", "unable", "to", "interfere", "with", "434", "repressor", "action", "in", "vivo"], "h": {"id": "C1332801", "name": "C1332801#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [8, 9]}}
{"token": ["Germline-inactivating", "mutations", "one", "allele", "of", "the", "C1431123#ent", "<e1>", "chromosome", "19p13.3", "been", "found", "in", "most", "C0031269#ent", "<e2>", "patients", "."], "h": {"id": "C1431123", "name": "C1431123#ent", "pos": [6, 7]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0031269", "name": "C0031269#ent", "pos": [14, 15]}}
{"token": ["To", "understand", "the", "mutation", "characteristic", "of", "C1431123#ent", "<e1>", "Chinese", "with", "C0031269#ent", "<e2>", "establish", "the", "gene", "diagnosis", "PJS", "."], "h": {"id": "C1431123", "name": "C1431123#ent", "pos": [6, 7]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0031269", "name": "C0031269#ent", "pos": [10, 11]}}
{"token": ["The", "widespread", "expression", "of", "C1431123#ent", "<e1>", "transcripts", "is", "consistent", "with", "elevated", "risk", "of", "multiple", "cancer", "in", "C0031269#ent", "<e2>", "patients", "."], "h": {"id": "C1431123", "name": "C1431123#ent", "pos": [4, 5]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0031269", "name": "C0031269#ent", "pos": [16, 17]}}
{"token": ["The", "C0812281#ent", "<e1>", "scavengers", ",", "Tempol", ",", "Tiron", "and", "C0041037#ent", "<e2>", ",", "did", "not", "significantly", "reduce", "levels", "of", "C0812281#ent", "<e1>", "or", "GSH", "depletion", "in", "ATO-treated", "HeLa", "cells"], "h": {"id": "C0041037", "name": "C0041037#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [1, 2]}}
{"token": ["C0812281#ent", "<e1>", "scavengers", "(", "Tempol", ",", "Tiron", ",", "C0041037#ent", "<e2>", "and", "NAC", ")", "did", "not", "down-regulate", "the", "production", "of", "C0812281#ent", "<e1>", "and", "inhibit", "apoptosis", "in", "AMA-treated", "cells", "."], "h": {"id": "C0041037", "name": "C0041037#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [0, 1]}}
{"token": ["Assuming", "that", "certain", "components", "of", "the", "C1367469#ent", "<e1>", "axis", "are", "involved", "in", "memory", "acquisition", "it", "is", "hypothesized", "that", "C0040616#ent", "<e2>", "affect", "learning", "through", "the", "regulation", "of", "C1367469#ent", "<e1>", "axis", "excitability", "."], "h": {"id": "C0040616", "name": "C0040616#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [6, 7]}}
{"token": ["The", "effects", "of", "exogenous", "administration", "of", "C1367469#ent", "<e1>", "hormones", "both", "clinically", "and", "in", "animal", "tests", "discussed", "and", "the", "effects", "of", "clinically", "used", "C0040616#ent", "<e2>", "and", "antidepressants", "on", "hormones", "of", "the", "C1367469#ent", "<e1>", "axis", "."], "h": {"id": "C0040616", "name": "C0040616#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [6, 7]}}
{"token": ["Among", "signaling", "events", "C0599295#ent", "<e1>", "IL-17", "in", "chondrocytes", "were", "the", "mitogen-activated", "protein", "MAP", ")", "kinases", "C1366765#ent", "<e2>", ",", "ERK2", ",", "JNK", ",", "and", "p38", "."], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366765", "name": "C1366765#ent", "pos": [15, 16]}}
{"token": ["The", "therapeutic", "effectiveness", "the", "C1254351#ent", "<e1>", "is", "insignificant", "in", "C0035457#ent", "<e2>", "adult", "extrinsic", "asthma", "cases", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [9, 10]}}
{"token": ["We", "conclude", "that", "Nasonex", "aerosol", "is", "a", "very", "effective", "and", "well", "tolerated", "C1254351#ent", "<e1>", "in", "the", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [18, 19]}}
{"token": ["Azelastine", "nasal", "spray", "an", "effective", "and", "well-tolerated", "C1254351#ent", "<e1>", "in", "the", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [13, 14]}}
{"token": ["Rats", "exposed", "only", "in", "utero", "to", "SPI", "or", "C4084748#ent", "<e1>", "had", "higher", "membrane", "C0694872#ent", "<e2>", "in", "mammary", "structures", "those", "lifetime-fed", "CAS", "or", "SPI", "."], "h": {"id": "C4084748", "name": "C4084748#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [13, 14]}}
{"token": ["Peripheral", "administration", "LPS", "promoted", "mast", "cell", "degranulation", "and", "increased", "C1413682#ent", "<e1>", ",", "BT", ",", "mucosal", "myeloperoxidase", "activity", "well", "as", "rat", "C0220300#ent", "<e2>", "levels", ",", "and", "PA", "in", "colonic", "content", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220300", "name": "C0220300#ent", "pos": [20, 21]}}
{"token": ["However", ",", "there", "were", "no", "significant", "differences", "in", "LVDP", ",", "LVEDP", ",", "C2744579#ent", "<e1>", "CP", "contents", ",", "and", "endothelium-independent", "vasodilator", "response", "C0885378#ent", "<e2>", "between", "the", "two", "cardioplegic", "groups", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0885378", "name": "C0885378#ent", "pos": [21, 22]}}
{"token": ["These", "results", "indicated", "that", "C0083154#ent", "<e1>", "directly", "interacted", "with", "the", "C0027203#ent", "<e2>", "at", "the", "catalytic", "site"], "h": {"id": "C0083154", "name": "C0083154#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["Dopamine", ",", "ergocryptine", ",", "and", "bromoergocryptine", "(", "also", "a", "C0178601#ent", "<e1>", "all", "inhibited", "prolactin", "synthesis", "epinephrine", "and", "C3887648#ent", "<e2>", "had", "little", "effect", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [17, 18]}}
{"token": ["In", "rhesus", "monkeys", "to", "discriminate", "C0027409#ent", "<e1>", "etorphine", "or", "ethylketazocine", ")", "from", "saline", ",", "C0078840#ent", "<e2>", "(", "1", "-", "10", "mg/kg", "i.m", ".", ")"], "h": {"id": "C0027409", "name": "C0027409#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0078840", "name": "C0078840#ent", "pos": [14, 15]}}
{"token": ["The", "consequence", "of", "t(5;7)(q33;q11.2", ")", "is", "an", "C1868262#ent", "<e1>", "encodes", "amino", "acids", "1", "950", "of", "C1415546#ent", "<e2>", "joined", "in-frame", "to", "the", "transmembrane", "and", "tyrosine", "kinase", "domains", "the", "PDGFbetaR.", "The", "reciprocal", "PDGFbetaR/HIP1", "transcript", "is", "not", "expressed", "."], "h": {"id": "C1868262", "name": "C1868262#ent", "pos": [7, 8]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1415546", "name": "C1415546#ent", "pos": [15, 16]}}
{"token": ["IgG", "aCL", "were", "found", "to", "have", "a", "significant", "association", "with", "thrombosis", "and", "thrombocytopenia", ",", "and", "IgM", "and", "aCL", "with", "C0002878#ent", "<e1>", "neutropenia", ",", "in", "C0024141#ent", "<e2>", "but", "not", "in", "the", "other", "autoimmune", "diseases"], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [19, 20]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [24, 25]}}
{"token": ["Systemic", "lupus", "erythematosus", "patients", "who", "develop", "C0002878#ent", "<e1>", "thrombocytopenic", "purpura", "from", "other", "C0024141#ent", "<e2>", "patients", "and", "are", "similar", "enough", "to", "be", "considered", "two", "related", "subsets", "with", "a", "more", "benign", "course", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [12, 13]}}
{"token": ["To", "elucidate", "the", "role", "of", "anticardiolipin", "antibodies", "aCL", ")", "in", "the", "pathogenesis", "of", "C0002878#ent", "<e1>", "patients", "with", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e2>", ")", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [20, 21]}}
{"token": ["C0002878#ent", "<e1>", "in", "patients", "with", "C0024141#ent", "<e2>", "include", "autoimmune", "hemolytic", "anemia", "AIHA", ")", "and", "thrombotic", "microangiopathic", "hemolytic", "anemia", "TMHA", ")", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [5, 6]}}
{"token": ["It", "is", "clear", "that", "structural", "changes", "cell", "death", "occurring", "after", "C1366479#ent", "<e1>", "activation", ",", "promote", "the", "cellular", "release", "C0534519#ent", "<e2>", "."], "h": {"id": "C1366479", "name": "C1366479#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [18, 19]}}
{"token": ["6", "known", "C0017337#ent", "<e1>", "such", "as", "for", "C1538865#ent", "<e2>", "KLF10", ",", "TPT1", "protein", "p02", "protein", "cDNA", "FLJ46859", "fis", ",", "DNMT1", "methyltrasferase", "etc", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1538865", "name": "C1538865#ent", "pos": [7, 8]}}
{"token": ["The", "catalytic", "subunit", "the", "C1412553#ent", "<e1>", "is", "an", "C1706373#ent", "<e2>", "with", "two", "nucleotide", "binding", "consensus", "sequences", "one", "in", "the", "N-terminal", "half", "and", "one", "in", "the", "C-terminal", "half", "the", "protein", "."], "h": {"id": "C1412553", "name": "C1412553#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [8, 9]}}
{"token": ["Indeed", "in", "both", "systems", ",", "forskolin", "inhibits", "the", "first", "step", "of", "the", "C1951340#ent", "<e1>", "(", "GBVD", ")", "assessing", "the", "existence", "of", "an", "oocyte", "C1382029#ent", "<e2>"], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [23, 24]}}
{"token": ["C0917964#ent", "<e1>", ",", "a", "direct", "stimulator", "of", "adenylate", "cyclase", "elicited", "comparable", "maximal", "C1333673#ent", "<e2>", "and", "cAMP", "responses", ",", "but", "an", "increased", "ED50", ",", "in", "dw", "cells", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [12, 13]}}
{"token": ["The", "C1420191#ent", "<e1>", "XAT", ")", "cDNAs", "are", "predicted", "to", "encode", "C0086376#ent", "<e2>", "of", "about", "50", "kDa", "."], "h": {"id": "C1420191", "name": "C1420191#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["The", "PLAP-like", "enzyme", "in", "seminoma", "was", "differentiated", "from", "C1412365#ent", "<e1>", "by", "digestion", "with", "C1417680#ent", "<e2>", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417680", "name": "C1417680#ent", "pos": [13, 14]}}
{"token": ["The", "C0243625#ent", "<e1>", "was", "one", "of", "these", "three", "C1260229#ent", "<e2>", ",", "which", "was", "associated", "with", "endo-beta-1,4-glucanase", "and", "beta-glucosidase", "activities", "."], "h": {"id": "C0243625", "name": "C0243625#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1260229", "name": "C1260229#ent", "pos": [8, 9]}}
{"token": ["In", "only", "two", "cases", "it", "could", "be", "stated", "for", "sure", "that", "a", "C0456386#ent", "<e1>", "was", "the", "cause", "of", "urticaria", ",", "one", "acute", "and", "C0263338#ent", "<e2>"], "h": {"id": "C0456386", "name": "C0456386#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0263338", "name": "C0263338#ent", "pos": [23, 24]}}
{"token": ["C3541311#ent", "<e1>", "encodes", "one", "of", "the", "two", "mammalian", "C4277608#ent", "<e2>", "of", "Saccharomyces", "cerevisiae", ",", "a", "ubiquitin-like", "fusion", "protein", "in", "nucleotide", "excision", "repair", "NER", ")", "."], "h": {"id": "C3541311", "name": "C3541311#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [8, 9]}}
{"token": ["HHR23A", "and", "C3541311#ent", "<e1>", "are", "the", "human", "C4277608#ent", "<e2>", "of", "Saccharomyces", "cerevisiae", "."], "h": {"id": "C3541311", "name": "C3541311#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [7, 8]}}
{"token": ["C3541311#ent", "<e1>", "is", "one", "of", "two", "human", "C4277608#ent", "<e2>", "of", "the", "Saccharomyces", "cerevisiae", "nucleotide", "excision", "repair", "NER", ")", "gene", "product", "and", "a", "component", "of", "a", "protein", "complex", "specifically", "complements", "the", "NER", "defect", "xeroderma", "pigmentosum", "group", "C", "XP-C", ")", "cell", "extracts", "in", "vitro"], "h": {"id": "C3541311", "name": "C3541311#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [7, 8]}}
{"token": ["Here", "we", "demonstrate", "that", "the", "stabilization", "effect", "exerted", "by", "C1419022#ent", "<e1>", "requires", "an", "intact", "N-terminal", "39", "amino", "acids", "C0525037#ent", "<e2>", "and", "occurs", "independently", "from", "N-terminal", "ubiquitination", "the", "protein", "."], "h": {"id": "C1419022", "name": "C1419022#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [18, 19]}}
{"token": ["The", "C0027203#ent", "<e1>", "is", "capable", "of", "catalyzing", "the", "chorination", "of", "C0021236#ent", "<e2>", "to", "7-chloroindole", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021236", "name": "C0021236#ent", "pos": [10, 11]}}
{"token": ["Some", "statins", "(", "atorvastatin", ",", "lovastatin", "and", "C0074554#ent", "<e1>", ")", "also", "requires", "metabolism", "by", "the", "C1142644#ent", "<e2>"], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [7, 8]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [15, 16]}}
{"token": ["Members", "of", "the", "C1846919#ent", "<e1>", "in", "particular", "the", "ataxia-telangiectasia", "mutated", "(ATM)", "kinase", "the", "catalytic", "subunit", "the", "C1335262#ent", "<e2>", "DNA-PKcs", ")", ",", "regulate", "cellular", "responses", "DNA", "double-strand", "breaks"], "h": {"id": "C1846919", "name": "C1846919#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335262", "name": "C1335262#ent", "pos": [16, 17]}}
{"token": ["Deaths", "in", "pemphigus", "and", "pemphigoid", "were", "more", "due", "to", "either", "complications", "of", "steroid", "therapy", "unassociated", "C0012634#ent", "<e1>", "than", "the", "C0277554#ent", "<e2>", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0277554", "name": "C0277554#ent", "pos": [19, 20]}}
{"token": ["In", "the", "first", "one", ",", "diffuse", "lesions", "glomeruli", ",", "either", "secondary", "to", "C0012634#ent", "<e1>", ",", "or", "apparently", "C0277554#ent", "<e2>", "as", "membranous", "or", "membrano-proliferative", "glomerulonephropathy", "GN", ")", "are", "responsible", "for", "the", "increased", "permeability", "of", "the", "glomerular", "capillaries"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0277554", "name": "C0277554#ent", "pos": [17, 18]}}
{"token": ["For", "this", "purpose", ",", "C1705639#ent", "<e1>", "in", "T", "cells", "the", "transmembrane", "adaptor", "LAT", "but", "the", "mechanism", "of", "C1705638#ent", "<e2>", "in", "B", "cells", "an", "enigma", "."], "h": {"id": "C1705639", "name": "C1705639#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705638", "name": "C1705638#ent", "pos": [17, 18]}}
{"token": ["Further", ",", "C0073096#ent", "<e1>", "inhibited", "NF-kappaB", "activation", "induced", "by", "C1843476#ent", "<e2>", ",", "but", "not", "by", "MyD88", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1843476", "name": "C1843476#ent", "pos": [9, 10]}}
{"token": ["Together", ",", "these", "results", "demonstrate", "that", "C0073096#ent", "<e1>", "specifically", "inhibits", "C1843476#ent", "<e2>", "signaling", "in", "the", "TLR3", "and", "TLR4", "pathway", "by", "targeting", "TANK-binding", "kinase", "1", "RIP1", "in", "C1843476#ent", "<e2>", "complex", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1843476", "name": "C1843476#ent", "pos": [10, 11]}}
{"token": ["Our", "findings", "suggest", "that", "C1520223#ent", "<e1>", "has", "histone", "methyltransferase", "and", "plays", "an", "important", "role", "in", "C1710463#ent", "<e2>", "a", "member", "of", "an", "RNA", "polymerase", "complex"], "h": {"id": "C1520223", "name": "C1520223#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [15, 16]}}
{"token": ["In", "summary", ",", "SMYD3-NY", "is", "a", "novel", "transcript", "variant", "of", "the", "C1520223#ent", "<e1>", "and", "SMYD3-NY", "protein", "may", "influence", "C1710463#ent", "<e2>", "spermatogenesis", "via", "HTMase", "activity", "."], "h": {"id": "C1520223", "name": "C1520223#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [18, 19]}}
{"token": ["C0010762#ent", "<e1>", ",", "but", "did", "not", "prevent", "the", "changes", "due", "to", "C0021246#ent", "<e2>", "in", "the", "non-cyt", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [11, 12]}}
{"token": ["The", "C0013720#ent", "<e1>", "EDS", ")", "comprises", "a", "heterogenous", "group", "of", "nine", "C0410787#ent", "<e2>", "characterized", "by", "hyperelasticity", "of", "skin", "hypermobility", "of", "joints", "to", "differing", "extents", "."], "h": {"id": "C0013720", "name": "C0013720#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0410787", "name": "C0410787#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "newly", "found", "frequent", "expression", "of", "chemokine", "receptors", "C1332824#ent", "<e1>", "and", "CCR10", "and", "their", "respective", "ligands", "CXCL16", "and", "C3274837#ent", "<e2>", "in", "HD-derived", "cell", "lines", "."], "h": {"id": "C1332824", "name": "C1332824#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3274837", "name": "C3274837#ent", "pos": [19, 20]}}
{"token": ["Further", "sequence", "analysis", "mapping", "showed", "that", "this", "locus", "contained", "three", "transglutaminase", "genes", "in", "tandem", ":", "EPB42", "(", "band", "4.2", "protein", ")", ",", "C1420717#ent", "<e1>", ",", "and", "a", "novel", "C0079429#ent", "<e2>", "(", "TGM7", ")", "."], "h": {"id": "C1420717", "name": "C1420717#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [28, 29]}}
{"token": ["A", "question", "in", "enzymatic", "DNA", "repair", "whether", "C0077845#ent", "<e1>", "and", "related", "C0114612#ent", "<e2>", "also", "use", "an", "extrahelical", "recognition", "mechanism", "to", "inspect", "the", "integrity", "of", "undamaged", "base", "pairs"], "h": {"id": "C0077845", "name": "C0077845#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0114612", "name": "C0114612#ent", "pos": [11, 12]}}
{"token": ["The", "enzyme", "activity", "C0041484#ent", "<e1>", ",", "catalase", ",", "and", "C0027021#ent", "<e2>", "and", "the", "number", "of", "metal", "ions", "in", "melanogenic", "subcellular", "compartments", "in", "pigment", "cells", "measured", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [9, 10]}}
{"token": ["This", "review", "examines", "the", "parameters", "of", "enzymatic", "browning", "in", "apple", "and", "apple", "products", "is", ",", "phenolic", "compounds", "C0041484#ent", "<e1>", ",", "and", "other", "factors", "(", "ascorbic", "acid", "C0027021#ent", "<e2>", ")", ",", "both", "qualitatively", "and", "quantitatively", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [26, 27]}}
{"token": ["Verapamil", ",", "a", "C3536851#ent", "<e1>", "reduces", "resistance", "of", "some", "tumors", "to", "C0014582#ent", "<e2>", "by", "inhibiting", "C0014582#ent", "<e2>", "efflux", "from", "resistant", "cells"], "h": {"id": "C3536851", "name": "C3536851#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [11, 12]}}
{"token": ["Liver", "sections", "a", "hen", "bearing", "a", "pancreatic", "tumor", "an", "unusually", "high", "content", "of", "C0079782#ent", "<e1>", "some", "hepatocytes", ",", "which", "were", "each", "clustered", "to", "C0848332#ent", "<e2>", "in", "the", "liver", "parenchyma"], "h": {"id": "C0079782", "name": "C0079782#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0848332", "name": "C0848332#ent", "pos": [23, 24]}}
{"token": ["Muscle-Eye-Brain", "disease", "MEB", ")", "and", "Walker-Warburg", "Syndrome", "C0265221#ent", "<e1>", ")", "have", "mutations", "in", "C1417679#ent", "<e2>", "encoding", "glycosyltransferases", "needed", "for", "O", "-mannosyl", "oligosaccharide", "synthesis", "."], "h": {"id": "C0265221", "name": "C0265221#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["C0265221#ent", "<e1>", "MEB", ")", "and", "Walker-Warburg", "Syndrome", "WWS", ")", "have", "mutations", "in", "C1417679#ent", "<e2>", "encoding", "glycosyltransferases", "needed", "for", "O", "-mannosyl", "oligosaccharide", "synthesis", "."], "h": {"id": "C0265221", "name": "C0265221#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["C1332794#ent", "<e1>", "inhibition", "reversed", "tolerance", "to", "only", "the", "hypoactive", "effects", "C1705616#ent", "<e2>", "."], "h": {"id": "C1332794", "name": "C1332794#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [10, 11]}}
{"token": ["Other", "known", "C0019643#ent", "<e1>", "inhibitors", "were", "also", "evaluated", "and", "found", "to", "possess", "C0003404#ent", "<e2>", "suggesting", "that", "C0019643#ent", "<e1>", "is", "an", "attractive", "target", "for", "the", "development", "of", "novel", "antiparasitic", "agents"], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003404", "name": "C0003404#ent", "pos": [12, 13]}}
{"token": ["Other", "known", "C0019643#ent", "<e1>", "inhibitors", "were", "also", "evaluated", "and", "found", "to", "possess", "antiparasitic", "activity", "suggesting", "that", "C0019643#ent", "<e1>", "is", "an", "attractive", "target", "for", "the", "development", "of", "novel", "C0003404#ent", "<e1>"], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003404", "name": "C0003404#ent", "pos": [27, 28]}}
{"token": ["On", "the", "other", "hand", ",", "a", "serine", "protease", "inhibitor", "nafamostat", "mesilate", "C1417739#ent", "<e1>", ")", "inhibits", "the", "enzyme", "activities", "of", "various", "C0030946#ent", "<e2>", "and", "coagulation", "factors"], "h": {"id": "C1417739", "name": "C1417739#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [20, 21]}}
{"token": ["For", "example", ",", "it", "is", "a", "potent", "inhibitor", "of", "C1417739#ent", "<e1>", "can", "modulate", "the", "C0030946#ent", "<e2>", "network", "through", "inhibition", "of", "plasmin", "."], "h": {"id": "C1417739", "name": "C1417739#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [14, 15]}}
{"token": ["Green", "fluorescent", "protein", "fusions", "the", "enzymes", "that", "catalyze", "the", "committed", "steps", "in", "PE", "synthesis", ",", "C0031622#ent", "<e1>", "and", "in", "CL", "synthesis", ",", "CL", "synthase", "C1826574#ent", "<e2>", "were", "localized", "mainly", "in", "the", "septal", "membranes", "B.", "subtilis", "cells", "."], "h": {"id": "C0031622", "name": "C0031622#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1826574", "name": "C1826574#ent", "pos": [24, 25]}}
{"token": ["We", "have", "recently", "reported", "that", "C0246719#ent", "<e1>", "preserves", "normal", "bone", "formation", "decreases", "bone", "remodeling", "women", "with", "C0029458#ent", "<e2>", "3", "years", "of", "treatment", "."], "h": {"id": "C0246719", "name": "C0246719#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "C0246719#ent", "<e1>", "administration", "is", "an", "effective", "anti-osteoporotic", "treatment", "in", "C0029458#ent", "<e2>", "women", "with", "IBD", "in", "remission", "."], "h": {"id": "C0246719", "name": "C0246719#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [12, 13]}}
{"token": ["C0378366#ent", "<e1>", "was", "more", "effective", "than", "C3536766#ent", "<e2>", "in", "providing", "effective", "prophylaxis", ",", "and", "maintained", "superiority", "in", "patients", "with", "additional", "risk"], "h": {"id": "C0378366", "name": "C0378366#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536766", "name": "C3536766#ent", "pos": [6, 7]}}
{"token": ["A", "further", "trial", "of", "more", "than", "2,000", "patients", "undergoing", "elective", "hip", "replacement", "the", "thromboprophylactic", "efficacy", "of", "C0378366#ent", "<e1>", "versus", "the", "low-molecular-weight", "heparin", "C3536766#ent", "<e2>", ")", "enoxaparin", "."], "h": {"id": "C0378366", "name": "C0378366#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3536766", "name": "C3536766#ent", "pos": [22, 23]}}
{"token": ["Somatic", "mosaicism", "to", "reversion", "of", "a", "pathogenic", "allele", "to", "C1883559#ent", "<e1>", "been", "described", "in", "several", "C3899988#ent", "<e2>"], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [15, 16]}}
{"token": ["To", "further", "investigate", "the", "molecular", "basis", "the", "thyroid", "hormonal", "control", "C1419703#ent", "<e1>", ",", "we", "have", "mapped", "the", "functional", "C1421114#ent", "<e2>", "sequences", "in", "the", "FUR", "region", "of", "the", "C1419703#ent", "<e1>"], "h": {"id": "C1419703", "name": "C1419703#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [18, 19]}}
{"token": ["We", "studied", "the", "effects", "of", "C0042842#ent", "<e1>", "repletion", "on", "rat", "insulin", "release", "and", "islet", "cellular", "retinol", "binding", "protein", "C1419317#ent", "<e2>", ")", "and", "cellular", "retinoic", "acid", "binding", "protein", "CRABP", ")", "."], "h": {"id": "C0042842", "name": "C0042842#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419317", "name": "C1419317#ent", "pos": [18, 19]}}
{"token": ["C1425074#ent", "<e1>", "also", "induced", "activation", "of", "mitogen-activated", "protein", "kinase", "C0170168#ent", "<e2>", "."], "h": {"id": "C1425074", "name": "C1425074#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [9, 10]}}
{"token": ["We", "show", "that", "the", "C3273676#ent", "<e1>", "gene", "is", "overexpressed", "in", "several", "tumors", "with", "viral", "insertions", "C3273676#ent", "<e1>", ",", "which", "results", "in", "the", "upregulation", "of", "C2699988#ent", "<e1>", "gene", "expression", "suggesting", "that", "C3273676#ent", "<e1>", "modulates", "EBF", "activity", "."], "h": {"id": "C3273676", "name": "C3273676#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2699988", "name": "C2699988#ent", "pos": [24, 25]}}
{"token": ["C3273676#ent", "<e1>", "is", "highly", "related", "to", "the", "C2699988#ent", "<e2>", "zinc", "finger", "gene", "(", "Ebfaz", ")", ",", "and", "all", "30", "zinc", "fingers", "in", "EVI3", "are", "conserved", "in", "EBFAZ", "."], "h": {"id": "C3273676", "name": "C3273676#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2699988", "name": "C2699988#ent", "pos": [7, 8]}}
{"token": ["Both", "type", "I", "C0011854#ent", "<e1>", "powerful", "and", "independent", "risk", "factors", "coronary", "artery", "disease", "C3813548#ent", "<e2>", ")", ",", "stroke", ",", "and", "peripheral", "arterial", "disease"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3813548", "name": "C3813548#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "lipoprotein", "profile", "Qatari", "patients", "with", "C0011854#ent", "<e1>", "T2DM", ")", "and", "to", "assess", "its", "relationship", "to", "coronary", "artery", "disease", "C3813548#ent", "<e2>", ")", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3813548", "name": "C3813548#ent", "pos": [26, 27]}}
{"token": ["C1366499#ent", "<e1>", "NEP", ")", ",", "a", "C0030940#ent", "<e2>", "is", "known", "to", "degrade", "several", "peptides", "which", "control", "cardiovascular", "homeostasis"], "h": {"id": "C1366499", "name": "C1366499#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [6, 7]}}
{"token": ["A", "sensitive", ",", "simple", ",", "rapid", "and", "precise", "method", "for", "the", "simultaneous", "determination", "of", "C0118168#ent", "<e1>", "(", "FOS", ")", "and", "C0020261#ent", "<e2>", "(", "HCT", ")", "in", "pharmaceutical", "formulations", "presented", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [20, 21]}}
{"token": ["The", "doses", "were", "increased", "to", "10", "mg", "of", "C0118168#ent", "<e1>", "or", "50", "mg", "of", "C0020261#ent", "<e2>", "if", "DBP", "remained", "above", "95", "mmHg", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [14, 15]}}
{"token": ["This", "study", "aimed", "to", "determine", "whether", "impaired", "renal", "function", "the", "pharmacokinetics", "and", "pharmacodynamics", "of", "a", "combination", "of", "C0118168#ent", "<e1>", "and", "hydrochlorothiazide", "(", "C0020261#ent", "<e2>", ")", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [22, 23]}}
{"token": ["Using", "a", "factorial", "design", "the", "antiatherosclerotic", "effect", "of", "two", "different", "antihypertensive", "drugs", "the", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitor", "C0118168#ent", "<e1>", "and", "the", "C0020261#ent", "<e2>", "be", "compared", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [22, 23]}}
{"token": ["We", "conclude", "that", ",", "in", "addition", "to", "widespread", "basal", "expression", ",", "C0010656#ent", "<e1>", "is", "regulated", "by", "glucocorticoids", "in", "a", "highly", "C1332691#ent", "<e2>", "manner", "in", "the", "renal", "cortex"], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [20, 21]}}
{"token": ["So", "beta-Lg", "is", "suggested", "to", "modulate", "the", "C1333200#ent", "<e1>", "the", "activation", "of", "C0031671#ent", "<e2>", "protein", "kinase", "C", "resulting", "in", "the", "TJ", "stabilization", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [12, 13]}}
{"token": ["We", "suggest", "that", "C1333200#ent", "<e1>", "disruption", "alters", "the", "spatial", "relationship", "phospholipase", "C", "IP3", "receptors", "impairing", "C0031671#ent", "<e2>", "signaling", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [15, 16]}}
{"token": ["H2O2-induced", "cAMP", "decreases", "are", "prevented", "by", "inhibiting", "phospholipase", "D.", "H2O2-induced", "C1333200#ent", "<e1>", "changes", "are", "prevented", "by", "inhibiting", "C0031671#ent", "<e2>", "phosphatidylinositol-4-phosphate", "kinase", "phosphoinositide", "turnover", "or", "by", "adding", "a", "synthetic", "peptide", "binds", "PIP2", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [17, 18]}}
{"token": ["We", "suggest", "that", "C1333200#ent", "<e1>", "disruption", "alters", "the", "spatial", "relationship", "C0031671#ent", "<e2>", "IP3", "receptors", "impairing", "phospholipase", "C-dependent", "signaling", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "alpha", "1-antitrypsin", "A1AT", ")", "deficiency", "in", "patients", "with", "C0600260#ent", "<e1>", "COAD", ")", "and", "other", "C0024115#ent", "<e2>"], "h": {"id": "C0600260", "name": "C0600260#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [16, 17]}}
{"token": ["These", "results", "are", "discussed", "with", "reference", "to", "C0268559#ent", "<e1>", "associated", "wtih", "C0268579#ent", "<e2>", "methylmalonic", "acidaemia", "as", "a", "possible", "contributory", "factor", "to", "the", "pathological", "mechanisms", "in", "these", "conditions", "."], "h": {"id": "C0268559", "name": "C0268559#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0268579", "name": "C0268579#ent", "pos": [11, 12]}}
{"token": ["The", "inhibitors", "of", "C3853644#ent", "<e1>", "be", "useful", "as", "C0035064#ent", "<e2>", "inducing", "maturation", "of", "Mks", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [8, 9]}}
{"token": ["In", "yeast", ",", "the", "C1419240#ent", "<e1>", "family", "of", "related", "C0086376#ent", "<e2>", "also", "includes", "Rad55", ",", "Rad57", "and", "Dmc1", "."], "h": {"id": "C1419240", "name": "C1419240#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["A", "43-year-old", "man", "presented", "with", "weakness", ",", "pruritus", ",", "C0015230#ent", "<e1>", "jaundice", "2", "weeks", "after", "treatment", "for", "C0040261#ent", "<e2>", "with", "terbinafine", "(", "Lamisil", ")", "was", "started", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040261", "name": "C0040261#ent", "pos": [17, 18]}}
{"token": ["Amongst", "these", "substances", ",", "phenformin", ",", "C0025598#ent", "<e1>", ",", "ethyloestrenol", ",", "stanozolol", "and", "a", "new", "substance", ",", "C0066805#ent", "<e2>", "have", "been", "studied", "."], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0066805", "name": "C0066805#ent", "pos": [17, 18]}}
{"token": ["C1522428#ent", "<e1>", "increased", "the", "secretion", "of", "C0032144#ent", "<e2>", "PA", ")", "activity", "by", "peritoneal", "macrophages", "a", "concentration-dependent", "manner", "on", "postsurgical", "Days", "0", ",", "3", ",", "10", ",", "and", "14", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032144", "name": "C0032144#ent", "pos": [6, 7]}}
{"token": ["P388D1", "is", "a", "murine", "C1522428#ent", "<e1>", "spontaneously", "secretes", "C0032144#ent", "<e2>", "PA", ";", "activated", "function", "and", "lysozyme", "(", "LYS", ";", "constitutive", "function", ")", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032144", "name": "C0032144#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "phospholipase", "A2", "PLA2", ")", "is", "activated", "by", "C2697656#ent", "<e1>", "resulting", "in", "the", "release", "of", "platelet-activating", "factor", "PAF", ")", "and", "C0023837#ent", "<e2>", "but", "not", "cyclo-oxygenase", "products"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [22, 23]}}
{"token": ["Renal-dose", "dopamine", "may", "be", "most", "valuable", "when", "combined", "with", "C0991617#ent", "<e1>", "targeting", "other", "events", "in", "C3854173#ent", "<e2>", "such", "as", "cast", "formation", "epithelial", "cell", "injury", "tubule", "regeneration"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [15, 16]}}
{"token": ["The", "role", "of", "these", "two", "C0991617#ent", "<e1>", "in", "the", "causation", "of", "the", "C3854173#ent", "<e2>", "discussed", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [12, 13]}}
{"token": ["The", "highlight", "of", "the", "study", "is", "the", "fact", "that", "L-dopa", "induces", "the", "C0014442#ent", "<e1>", "MAT", "and", "C0007407#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007407", "name": "C0007407#ent", "pos": [16, 17]}}
{"token": ["Live", "cell", "imaging", "localization", "of", "GFP-tagged", "C1538439#ent", "<e1>", "to", "many", "cell", "compartments", "including", "specific", "association", "with", "C1417613#ent", "<e2>", "."], "h": {"id": "C1538439", "name": "C1538439#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [16, 17]}}
{"token": ["Distinct", "gender", "differences", "in", "expression", "of", "GST", "subunits", "observed", "for", "C0023899#ent", "<e1>", ",", "heart", ",", "kidney", "and", "gonads", ",", "whereas", "C0796516#ent", "<e2>", "expression", "was", "similar", "in", "brain", "and", "lung", "for", "both", "genders", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0796516", "name": "C0796516#ent", "pos": [20, 21]}}
{"token": ["Exercise", "enhanced", "UDP-GT", "activity", "in", "C0023899#ent", "<e1>", "and", "lung", "while", "ethanol", "had", "no", "effect", "C0796516#ent", "<e2>", "activity", "was", "induced", "in", "the", "C0023899#ent", "<e1>", "by", "the", "combined", "treatment"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0796516", "name": "C0796516#ent", "pos": [14, 15]}}
{"token": ["The", "change", "in", "monomeric", "actin", "measured", "in", "human", "polymorphonuclear", "leukocytes", "PMN", ")", "and", "platelets", ",", "using", "the", "C0011519#ent", "<e1>", "assay", ",", "after", "stimulation", "with", "various", "C0035064#ent", "<e2>", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [25, 26]}}
{"token": ["Enucleations", "were", "performed", "6", "1/2", "weeks", ",", "five", "months", ",", "and", "11", "months", "after", "irradiation", "for", "C0017605#ent", "<e1>", "total", "retinal", "detachment", "increase", "in", "retinal", "detachment", "and", "C0017609#ent", "<e2>", "respectively", "."], "h": {"id": "C0017605", "name": "C0017605#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017609", "name": "C0017609#ent", "pos": [26, 27]}}
{"token": ["The", "5-hydroxytryptophan-induced", "rise", "was", "prevented", "by", "the", "serotonergic", "antagonist", "C0010620#ent", "<e1>", "but", "not", "by", "the", "C0242702#ent", "<e2>", "haloperidol", "."], "h": {"id": "C0010620", "name": "C0010620#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242702", "name": "C0242702#ent", "pos": [15, 16]}}
{"token": ["This", "stimulating", "effect", "of", "5-HT", "was", "completely", "prevented", "by", "pretreatment", "with", "C0010620#ent", "<e1>", ",", "a", "blocker", "of", "5-HT", "receptors", "whereas", "fluphenazine", ",", "a", "C0242702#ent", "<e2>", "was", "unable", "to", "block", "it", "."], "h": {"id": "C0010620", "name": "C0010620#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242702", "name": "C0242702#ent", "pos": [23, 24]}}
{"token": ["To", "overcome", "these", "limitations", ",", "we", "used", "the", "C1327895#ent", "<e1>", "a", "model", "Ag", "and", "designed", "a", "C0017337#ent", "<e2>", "containing", "the", "lysosomal-associated", "membrane", "protein", "1", "sequence", "(", "Sig-pp65-LAMP1", ")", "to", "target", "pp65", "to", "the", "class", "II", "."], "h": {"id": "C1327895", "name": "C1327895#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["However", ",", "although", "C0117234#ent", "<e1>", "is", "a", "poor", "inhibitor", "of", "the", "C1413855#ent", "<e2>", "it", "suppresses", "aldosterone", "release", "by", "ACTH-stimulated", "human", "adrenocortical", "cells"], "h": {"id": "C0117234", "name": "C0117234#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413855", "name": "C1413855#ent", "pos": [11, 12]}}
{"token": ["Mice", "expressing", "C1334126#ent", "<e1>", "on", "their", "neutrophils", "responded", "rapidly", "to", "experimental", "C0042029#ent", "<e2>", "clearing", "the", "infection", "from", "the", "kidneys", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [11, 12]}}
{"token": ["These", "results", "emphasize", "the", "importance", "of", "C1334126#ent", "<e1>", "for", "the", "innate", "defense", "C0042029#ent", "<e2>"], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [12, 13]}}
{"token": ["C0036442#ent", "<e1>", "and", "apomorphine", "in", "locomotor", "C0002763#ent", "<e2>", "doses", "showed", "additive", "effects"], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [6, 7]}}
{"token": ["To", "determine", "whether", "nonspecific", "C0002763#ent", "<e1>", "effects", "can", "attenuate", "the", "cognitive", "impairment", "induced", "by", "C0036442#ent", "<e2>", ",", "we", "studied", "the", "effects", "of", "C0036442#ent", "<e2>", "and", "the", "C0002763#ent", "<e1>", "dextroamphetamine", "in", "17", "young", "normal", "volunteers"], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [4, 5]}}
{"token": ["This", "article", "reviews", "the", "hepatic", "complications", "C0012634#ent", "<e1>", "that", "are", "primarily", "C0024115#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [11, 12]}}
{"token": ["These", "physiologic", "changes", "alter", "the", "clinical", "presentation", "such", "C0012634#ent", "<e1>", ",", "making", "the", "diagnosis", "and", "treatment", "of", "C0024115#ent", "<e2>", "challenging", "for", "the", "clinician", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [17, 18]}}
{"token": ["To", "study", "the", "influence", "of", "C1142644#ent", "<e1>", "inhibition", "by", "ketoconazole", "on", "the", "disposition", "of", "C0078569#ent", "<e2>", "in", "individuals", "with", "different", "CYP2D6", "pheno-", "and", "genotypes", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0078569", "name": "C0078569#ent", "pos": [14, 15]}}
{"token": ["Overall", ",", "C0078569#ent", "<e1>", "did", "not", "inhibit", "the", "CYP3A4-mediated", "metabolism", "of", "alprazolam", "in", "vivo", "which", "corroborates", "other", "in", "vitro", "in", "vivo", "data", "showing", "a", "lack", "of", "C1142644#ent", "<e2>", "inhibition", "with", "C0078569#ent", "<e1>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [26, 27]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0078569", "name": "C0078569#ent", "pos": [2, 3]}}
{"token": ["One", "patient", "had", "C0014038#ent", "<e1>", "with", "C0085648#ent", "<e2>", ",", "and", "the", "other", "C0085648#ent", "<e2>", "."], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [6, 7]}}
{"token": ["Peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "from", "patients", "with", "C0003873#ent", "<e1>", "RA", ")", "have", "increased", "expression", "of", "nitric", "oxide", "synthase", "type", "2", "C1417760#ent", "<e2>", ")", "protein", "and", "enhanced", "formation", "of", "nitric", "oxide", "NO", ")", "that", "correlate", "with", "disease", "activity"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [22, 23]}}
{"token": ["Blood", "mononuclear", "cells", "C0003873#ent", "<e1>", "patients", "had", "increased", "NOS", "activity", "and", "increased", "C1417760#ent", "<e2>", "antigen", "content", "as", "compared", "to", "those", "from", "normal", "subjects", "and", "responded", "to", "interferon-gamma", "with", "increased", "NOS", "expression", "and", "nitrite/nitrate", "production", "in", "vitro"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [12, 13]}}
{"token": ["Peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "from", "patients", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "have", "increased", "expression", "of", "nitric", "oxide", "synthase", "type", "2", "C1417760#ent", "<e2>", ")", "protein", "and", "enhanced", "formation", "of", "nitric", "oxide", "NO", ")", "that", "correlate", "with", "disease", "activity"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [23, 24]}}
{"token": ["The", "aar1", "and", "C1423806#ent", "<e1>", "mutants", "were", "also", "defective", "in", "responding", "to", "C0719425#ent", "<e2>", "and", "osmotic", "stress"], "h": {"id": "C1423806", "name": "C1423806#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0719425", "name": "C0719425#ent", "pos": [12, 13]}}
{"token": ["All", "patients", "with", "systemic", "C3495559#ent", "<e1>", "and", "CTD", "and", "56", "%", "of", "the", "patients", "with", "C3890205#ent", "<e2>", "under", "treatment", "with", "glucocorticoids", "."], "h": {"id": "C3495559", "name": "C3495559#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C3890205", "name": "C3890205#ent", "pos": [15, 16]}}
{"token": ["A", "heat-stable", "factor", "(", "HSF", ")", "purified", "from", "the", "spleen", "of", "a", "patient", "with", "C0268251#ent", "<e1>", "increased", "the", "sensitivity", "of", "the", "rat", "C0005223#ent", "<e2>", "all", "of", "the", "NAPE", "derivatives", "."], "h": {"id": "C0268251", "name": "C0268251#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [22, 23]}}
{"token": ["An", "adult", "with", "C0268251#ent", "<e1>", "injected", "with", "liposomes", "containing", "human", "glucocerebroside", ":", "C0005223#ent", "<e2>", "."], "h": {"id": "C0268251", "name": "C0268251#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [12, 13]}}
{"token": ["The", "diagnosis", "and", "monitoring", "of", "these", "C0033740#ent", "<e1>", "trypanosomiasis", "and", "C0024530#ent", "<e2>", ")", "involved", "repetitive", "sampling", "of", "blood", ",", "which", "provides", "many", "opportunities", "for", "spreading", "the", "ancestral", "HIV-1", "infection"], "h": {"id": "C0033740", "name": "C0033740#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [10, 11]}}
{"token": ["Like", "many", "C0086376#ent", "<e1>", ",", "dystrophin", "and", "C1414176#ent", "<e2>", "have", "diversified", "in", "the", "vertebrate", "clade", "as", "have", "their", "binding", "partners", ",", "yielding", "specialized", "complexes", "tailored", "to", "different", "cellular", "and", "subcellular", "locations", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414176", "name": "C1414176#ent", "pos": [7, 8]}}
{"token": ["Lastly", ",", "we", "measured", "C1419090#ent", "<e1>", "and", "suppressor", "of", "cytokine", "signaling", "C3275256#ent", "<e2>", "and", "-3", "and", "CIS", ",", "which", "reflect", "the", "level", "of", "prolactin", "signaling", "mRNAs", "in", "response", "to", "sulpiride", "and", "estradiol", "."], "h": {"id": "C1419090", "name": "C1419090#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3275256", "name": "C3275256#ent", "pos": [11, 12]}}
{"token": ["In", "experimental", "autoimmune", "encephalomyelitis", "an", "animal", "model", "MS", ",", "and", "experimental", "autoimmune", "neuritis", "an", "animal", "model", "C4083008#ent", "<e1>", ",", "different", "synthetic", "inhibitors", "targeting", "C0919336#ent", "<e2>", "activity", "are", "able", "to", "suppress", "and", "even", "reverse", "ongoing", "disease", "."], "h": {"id": "C4083008", "name": "C4083008#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [23, 24]}}
{"token": ["We", "demonstrate", "here", "that", "polyethylene", "glycol", "PEG", ")", "6,000", "protects", "biodegradable", "poly(D", ",", "C3537171#ent", "<e1>", "nanoparticles", "(", "PLA", "C1824810#ent", "<e2>", ")", "from", "extensive", "uptake", "by", "monocytes", "in", "plasma", "."], "h": {"id": "C3537171", "name": "C3537171#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1824810", "name": "C1824810#ent", "pos": [18, 19]}}
{"token": ["The", "relaxation", "response", "enhanced", "by", "the", "C0085387#ent", "<e1>", "indomethacin", "and", "inhibited", "by", "lipoxygenase", "inhibitors", "including", "nordihydroguaiaretic", "acid", "C0384553#ent", "<e2>", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0384553", "name": "C0384553#ent", "pos": [17, 18]}}
{"token": ["In", "this", "paper", ",", "C1415944#ent", "<e1>", "of", "the", "unbiased", "autocovariance", "function", "of", "the", "C0240940#ent", "<e2>", "EEG", "data", "was", "used", "to", "detect", "electrographic", "seizure", "activity", "."], "h": {"id": "C1415944", "name": "C1415944#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0240940", "name": "C0240940#ent", "pos": [13, 14]}}
{"token": ["It", "has", "been", "suggested", "that", "there", "is", "an", "overlap", "between", "this", "C0039082#ent", "<e1>", "and", "another", "called", "C0265210#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0265210", "name": "C0265210#ent", "pos": [16, 17]}}
{"token": ["The", "switch-over", "of", "the", "C0027203#ent", "<e1>", "from", "the", "C0043317#ent", "<e2>", "the", "nitrate", "reductase", "is", "associated", "with", "conformational", "changes", "of", "the", "enzyme", "molecule", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [8, 9]}}
{"token": ["Mo(V", ")", "EPR", "showed", "the", "presence", "of", "a", "weak", "rapid", "signal", "corresponding", "to", "the", "C0027203#ent", "<e1>", "of", "low", "C0043317#ent", "<e2>", "activity", "and", "a", "slow", "signal", "a", "significant", "content", "of", "desulpho-form", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [18, 19]}}
{"token": ["Aqueous", "ophthalmic", "solutions", "of", "C0080151#ent", "<e1>", "have", "been", "made", "using", "sodium", ",", "potassium", ",", "C1306531#ent", "<e2>", "and", "lysine", "salts", "complexing", "with", "cyclodextrins/solubilizer", "."], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1306531", "name": "C1306531#ent", "pos": [14, 15]}}
{"token": ["Evidently", "streptokinase", "can", "form", "complexes", "with", "LD", "in", "vivo", "either", "C0038418#ent", "<e1>", "infection", ",", "with", "consequent", "alteration", "of", "the", "LD", "C0022173#ent", "<e2>", "pattern", "."], "h": {"id": "C0038418", "name": "C0038418#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [20, 21]}}
{"token": ["The", "objective", "was", "to", "determine", "the", "C0119860#ent", "<e1>", "GAGs", ")", "of", "the", "extracellular", "matrix", "C3889469#ent", "<e2>", ")", "in", "pre-", "and", "postmenopausal", "women", "."], "h": {"id": "C0119860", "name": "C0119860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3889469", "name": "C3889469#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "elucidate", "the", "local", "immunopathogenesis", "of", "C0206061#ent", "<e1>", "by", "CMV", "or", "other", "C0035064#ent", "<e2>", "in", "BMT", "recipients", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "benzoyl", "peroxide", "its", "antimicrobial", "action", "the", "follicles", "and", "inhibits", "P", "C0001144#ent", "<e1>", ",", "while", "the", "antimicrobial", "effectiveness", "C0019435#ent", "<e2>", "is", "limited", "to", "the", "skin", "surface"], "h": {"id": "C0001144", "name": "C0001144#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0019435", "name": "C0019435#ent", "pos": [20, 21]}}
{"token": ["Long-term", "results", "of", "open", "synovectomy", "of", "the", "elbow", "with", "C0038013#ent", "<e1>", "RA", ")", "were", "reviewed", "in", "15", "C0239266#ent", "<e2>", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0239266", "name": "C0239266#ent", "pos": [17, 18]}}
{"token": ["The", "C0017337#ent", "<e1>", "giving", "rise", "to", "these", "alternative", "transcripts", "has", "been", "named", "C1420135#ent", "<e2>", "Orct", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420135", "name": "C1420135#ent", "pos": [12, 13]}}
{"token": ["C0069585#ent", "<e1>", ",", "a", "new", "specific", "and", "selective", "C3536821#ent", "<e2>", "was", "given", "at", "increasing", "single", "oral", "doses", "to", "100", "mg", "."], "h": {"id": "C0069585", "name": "C0069585#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536821", "name": "C3536821#ent", "pos": [8, 9]}}
{"token": ["Assuming", "that", "the", "C0238051#ent", "<e1>", "involved", "in", "the", "pathophysiology", "of", "C0149931#ent", "<e2>", ",", "we", "compared", "cerebral", "vasoreactivity", "adolescents", "both", "during", "a", "C0149931#ent", "<e2>", "attack", "and", "a", "headache-free", "interval", "."], "h": {"id": "C0238051", "name": "C0238051#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [10, 11]}}
{"token": ["Dilatation", "of", "the", "C0238051#ent", "<e1>", "recognised", "to", "be", "involved", "in", "the", "pathophysiology", "of", "C0149931#ent", "<e2>", "."], "h": {"id": "C0238051", "name": "C0238051#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [13, 14]}}
{"token": ["These", "triggers", "potentially", "can", "act", "at", "various", "sites", "within", "the", "C0238051#ent", "<e1>", "the", "central", "nervous", "system", "promote", "the", "development", "of", "C0149931#ent", "<e2>"], "h": {"id": "C0238051", "name": "C0238051#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [20, 21]}}
{"token": ["The", "most", "common", "course", "of", "C3890176#ent", "<e1>", "to", "start", "as", "an", "C3495559#ent", "<e2>", "and", "progress", ",", "usually", "to", "polyarthritis", "."], "h": {"id": "C3890176", "name": "C3890176#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [11, 12]}}
{"token": ["Multiple", "modality", "treatment", "with", "the", "use", "of", "C0003286#ent", "<e1>", ",", "neuroleptics", ",", "antidepressants", "and", "C0304403#ent", "<e2>", "is", "recommended", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0304403", "name": "C0304403#ent", "pos": [14, 15]}}
{"token": ["The", "types", "of", "neuropsychotropic", "drugs", "may", "be", "useful", "in", "treating", "cancer", "pain", "the", "tricyclic", "antidepressants", "C0003286#ent", "<e1>", ",", "neuroleptics", ",", "antihistamines", ",", "C0304403#ent", "<e2>", ",", "and", "benzodiazepines", ",", "as", "well", "as", "systemic", "local", "anesthetics"], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0304403", "name": "C0304403#ent", "pos": [22, 23]}}
{"token": ["A", "complete", "computer", "program", "the", "image", "analysis", "C1866260#ent", "<e1>", "experiments", "has", "been", "developed", "for", "an", "80486", "C3810569#ent", "<e2>", ",", "using", "the", "commercially", "available", "software", "package", "Optimas", "as", "the", "basis", "for", "image", "recording", "."], "h": {"id": "C1866260", "name": "C1866260#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "the", "range", "and", "prevalence", "of", "C0018939#ent", "<e1>", "patients", "with", "C0013575#ent", "<e2>", "ED", ")", "and", "provide", "a", "general", "review", "of", "its", "multiple", "otolaryngological", "manifestations", "."], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013575", "name": "C0013575#ent", "pos": [11, 12]}}
{"token": ["We", "report", "here", "a", "gene", "we", "call", "byr2", "that", "can", "encode", "a", "predicted", "C0010536#ent", "<e1>", "can", "partially", "suppress", "defects", "in", "C1428880#ent", "<e2>", "mutants", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1428880", "name": "C1428880#ent", "pos": [20, 21]}}
{"token": ["We", "describe", "the", "aetiology", "of", "C0011991#ent", "<e1>", "the", "characteristics", "of", "C0035869#ent", "<e2>", "Shahrekord", ",", "Iran", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0035869", "name": "C0035869#ent", "pos": [10, 11]}}
{"token": ["C0014378#ent", "<e1>", "are", "well", "known", "causes", "of", "acute", "respiratory", "C4082764#ent", "<e2>", "with", "tropism", "for", "the", "central", "nervous", "system", "muscles", ",", "and", "heart", "."], "h": {"id": "C0014378", "name": "C0014378#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4082764", "name": "C4082764#ent", "pos": [9, 10]}}
{"token": ["With", "the", "exception", "of", "one", "examination", ",", "C1420470#ent", "<e1>", "values", "were", "below", "2", "Gy", ":", "the", "limit", "for", "C0041834#ent", "<e2>", "."], "h": {"id": "C1420470", "name": "C1420470#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [18, 19]}}
{"token": ["Dehydroepiandrosterone", "sulfate", "DHEAS", ")", ",", "testosterone", ",", "androstenedione", ",", "17-beta", "estradiol", "C1366439#ent", "<e1>", "been", "assayed", "in", "50", "HLA-identical", "C0003873#ent", "<e2>", "RA", ")", "discordant", "sibling", "pairs"], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [18, 19]}}
{"token": ["According", "to", "our", "model", ",", "the", "GPX1", "*", "2", "allele", "has", "an", "epistatic", "effect", "the", "C1415481#ent", "<e1>", "genotype", "by", "lowering", "its", "protection", "against", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C1415481", "name": "C1415481#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [23, 24]}}
{"token": ["These", "results", "also", "demonstrate", "the", "use", "of", "cDNA", "macroarrays", "an", "effective", "approach", "in", "identifying", "C1417679#ent", "<e1>", "implicated", "in", "a", "C0024899#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024899", "name": "C0024899#ent", "pos": [19, 20]}}
{"token": ["The", "tumors", "were", "genotyped", "for", "their", "common", "activating", "mutations", ":", "BRAF", "V600E", "point", "mutation", ",", "C1865984#ent", "<e1>", "and", "3", "rearrangement", "and", "point", "mutations", "of", "KRAS", ",", "C0079972#ent", "<e2>", "and", "NRAS", "."], "h": {"id": "C1865984", "name": "C1865984#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0079972", "name": "C0079972#ent", "pos": [26, 27]}}
{"token": ["By", "confocal", "laser", "scanning", "microscopy", "subcellular", "fractionation", "it", "was", "demonstrated", "that", "C1413800#ent", "<e1>", "localizes", "to", "the", "C3179066#ent", "<e2>", "and", "is", "enriched", "in", "stroma", "thylakoids"], "h": {"id": "C1413800", "name": "C1413800#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [16, 17]}}
{"token": ["Immunoreactive", "C1366490#ent", "<e1>", "is", "seen", "in", "both", "C1412113#ent", "<e2>", "and", "AT2", "cells", "similar", "amounts", "."], "h": {"id": "C1366490", "name": "C1366490#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412113", "name": "C1412113#ent", "pos": [7, 8]}}
{"token": ["Recent", "studies", "have", "shown", "that", "TFIIH", "copurifies", "with", "the", "C1413181#ent", "<e1>", "CAK", ")", "that", "includes", "cdk7", ",", "C0258442#ent", "<e2>", "and", "p36/MAT1", "."], "h": {"id": "C1413181", "name": "C1413181#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0258442", "name": "C0258442#ent", "pos": [17, 18]}}
{"token": ["The", "p37", "transcript", "level", "is", "nearly", "as", "high", "as", "that", "for", "C1413181#ent", "<e1>", "in", "procyclic", "form", ",", "while", "the", "C0258442#ent", "<e2>", "is", "low", "."], "h": {"id": "C1413181", "name": "C1413181#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0258442", "name": "C0258442#ent", "pos": [19, 20]}}
{"token": ["In", "mitotic", "cells", "this", "is", "accomplished", "by", "the", "C1413181#ent", "<e1>", "(", "CAK", ")", ",", "which", "is", "a", "complex", "of", "C0258442#ent", "<e2>", "Cdk7", "."], "h": {"id": "C1413181", "name": "C1413181#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0258442", "name": "C0258442#ent", "pos": [19, 20]}}
{"token": ["The", "hamster", "homologue", "also", "known", "as", "haHIPK2", "or", "C2698696#ent", "<e1>", ",", "was", "used", "for", "further", "characterization", "of", "interactions", "between", "C1335624#ent", "<e2>", "and", "members", "of", "the", "p53", "protein", "family"], "h": {"id": "C2698696", "name": "C2698696#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335624", "name": "C1335624#ent", "pos": [19, 20]}}
{"token": ["C1567160#ent", "<e1>", "human", "leukocyte", "protease-HLP", ",", "C1334043#ent", "<e2>", "to", "murine", "granzyme", "B", "mRNA", "expression", "was", "studied", "in", "comparison", "to", "perforin", "."], "h": {"id": "C1567160", "name": "C1567160#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}}
{"token": ["The", "C0003392#ent", "<e1>", "docetaxel", ")", "inhibited", "C1522575#ent", "<e2>", "human", "umbilical", "vein", "endothelial", "cell", "(", "HUVEC", ")", "migration", "in", "vitro", "concentrations", "substantially", "lower", "than", "required", "to", "cause", "cell", "cycle", "arrest", "apoptosis", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", "pyocyanin", "and", "Pch", ",", "rather", "than", "C1825840#ent", "<e1>", ",", "are", "the", "determinants", "for", "induced", "resistance", "in", "C2987364#ent", "<e2>", "P.", "aeruginosa", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}}
{"token": ["The", "ability", "of", "crude", "growth", "preparations", "to", "stimulate", "C1417932#ent", "<e1>", "activity", "in", "some", "tissues", "may", "be", "a", "function", "of", "C0032002#ent", "<e2>", "in", "addition", "to", "GH", ",", "which", "have", "minimal", "growth", "promoting", "activity", "."], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [19, 20]}}
{"token": ["C1424852#ent", "<e1>", "visual", "pigment", "C1417679#ent", "<e2>", "have", "been", "studied", "in", "a", "wide", "range", "of", "vertebrates", "including", "a", "number", "of", "mammalian", "species", "."], "h": {"id": "C1424852", "name": "C1424852#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}}
{"token": ["The", "human", "C1424852#ent", "<e1>", "and", "cone", "NCKX", "C1417679#ent", "<e2>", "were", "localized", "to", "chromosomes", "15q22", "and", "9p22", ",", "respectively", "."], "h": {"id": "C1424852", "name": "C1424852#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}}
{"token": ["The", "result", "of", "detecting", "the", "expression", "of", "C1704700#ent", "<e1>", "of", "CD138", "+", "(", "Syndecan-1", ")", "myeloma", "cells", "the", "obvious", "up-regulation", "of", "C1704700#ent", "<e1>", "expression", "after", "exposure", "to", "C0046319#ent", "<e1>", "for", "72", "hours", "."], "h": {"id": "C1704700", "name": "C1704700#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0046319", "name": "C0046319#ent", "pos": [27, 28]}}
{"token": ["Degradation", "of", "cartilage", "in", "rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "may", "be", "in", "part", "due", "to", "release", "of", "C0962754#ent", "<e2>", "from", "specific", "granules", "of", "polymorphonuclear", "neutrophil", "leukocytes", "PMNs", ")", "during", "degranulation", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [17, 18]}}
{"token": ["Synovial-fluid", "neutrophils", "from", "C0003873#ent", "<e1>", "patients", "were", "found", "to", "release", "C0962754#ent", "<e2>", "in", "30", "%", "active", "form", "compared", "to", "same", "patients", "'", "peripheral", "blood", "neutrophils", "which", "released", "C0962754#ent", "<e2>", "in", "completely", "latent", "form", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [10, 11]}}
{"token": ["Carbohydrate", "response", "element-binding", "protein", "C1826259#ent", "<e1>", ")", "is", "a", "basic", "C1420632#ent", "<e2>", "binds", "to", "the", "carbohydrate", "response", "element", "the", "promoter", "of", "certain", "lipogenic", "and", "glycolytic", "genes"], "h": {"id": "C1826259", "name": "C1826259#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [10, 11]}}
{"token": ["C1826259#ent", "<e1>", "(", "carbohydrate-response-element-binding", "protein", "is", "a", "basic", "C1420632#ent", "<e2>", "regulates", "expression", "of", "these", "genes", "."], "h": {"id": "C1826259", "name": "C1826259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [8, 9]}}
{"token": ["The", "carbohydrate", "response", "protein", "(", "C1826259#ent", "<e1>", ")", "is", "a", "newly", "identified", "basic", "C1420632#ent", "<e2>", "to", "regulate", "the", "expression", "of", "the", "glucose-responsive", "gene", "pyruvate", "kinase", "."], "h": {"id": "C1826259", "name": "C1826259#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [13, 14]}}
{"token": ["C1412361#ent", "<e1>", "an", "enzyme", "encoded", "by", "the", "C0003693#ent", "<e2>", "and", "plays", "an", "important", "role", "in", "the", "synthesis", "of", "leukotrienes", "."], "h": {"id": "C1412361", "name": "C1412361#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "we", "demonstrate", "that", "C1705550#ent", "<e1>", "activates", "the", "mono-ubiquitination", "of", "both", "FANCD2", "and", "C1366837#ent", "<e2>", "and", "the", "phosphorylation", "of", "RPA2", ",", "signaling", "processive", "DNA", "replication", "arrest"], "h": {"id": "C1705550", "name": "C1705550#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [14, 15]}}
{"token": ["Activation", "of", "the", "macrophage", "cell", "line", "264.7", "with", "lipopolysaccharide", "(", "LPS", ")", "transiently", "activates", "protein", "kinase", "C", "zeta", "PKC", "C3889400#ent", "<e1>", ")", "and", "Jun", "N-terminal", "kinase", "JNK", ")", "through", "a", "C3813591#ent", "<e2>"], "h": {"id": "C3889400", "name": "C3889400#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3813591", "name": "C3813591#ent", "pos": [30, 31]}}
{"token": ["Patterns", "of", "fragmentation", "for", "straight-chain", ",", "C0024776#ent", "<e1>", ",", "unsaturated", "and", "cyclic", "fatty", "acids", "described", "together", "with", "those", "containing", "C0020402#ent", "<e2>", ",", "epoxy-", ",", "keto-", ",", "and", "ether", "groups"], "h": {"id": "C0024776", "name": "C0024776#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [19, 20]}}
{"token": ["The", "expression", "of", "TSP1", "and", "C1336627#ent", "<e1>", "in", "invasive", "breast", "ductal", "carcinoma", "C0669372#ent", "<e2>", "did", "not", "significantly", "correlate", "with", "any", "of", "the", "prognostic", "factors", "(", "tumor", "size", "lymph", "node", "status", "morphology", ",", "and", "hormone", "receptor", "status", "."], "h": {"id": "C1336627", "name": "C1336627#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}}
{"token": ["LOXL2", ",", "LOXL3", "and", "C1424794#ent", "<e1>", ",", "secreted", "and", "active", "C3541394#ent", "<e2>", ",", "were", "also", "noted", "in", "association", "with", "diverse", "tumor", "types"], "h": {"id": "C1424794", "name": "C1424794#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}}
{"token": ["Membrane", "fraction", "C0062108#ent", "<e1>", "was", "prepared", "from", "the", "lysate", "of", "a", "mutant", "strain", "Halobacterium", "halobium", "C1704920#ent", "<e2>", ",", "which", "is", "defective", "in", "bacteriorhodopsin", "synthesis"], "h": {"id": "C0062108", "name": "C0062108#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704920", "name": "C1704920#ent", "pos": [15, 16]}}
{"token": ["Analysis", "indicate", "that", "C0023218#ent", "<e1>", "a", "common", "phenomenon", "associated", "with", "comorbid", "disorders", "especially", "peripheral", "vascular", "C0027765#ent", "<e2>"], "h": {"id": "C0023218", "name": "C0023218#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [15, 16]}}
{"token": ["Clomipramine", "used", "alone", "is", "an", "C0728960#ent", "<e1>", "organic", "pain", "to", "a", "lesion", "of", "the", "peripheral", "nervous", "system", "in", "particular", "C0032768#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032768", "name": "C0032768#ent", "pos": [19, 20]}}
{"token": ["In", "order", "to", "test", "baclofen", "'s", "C0728960#ent", "<e1>", "properties", "in", "more", "chronic", "pain", "conditions", "we", "selected", "C0032768#ent", "<e2>", "diabetic", "neuropathy", "as", "possible", "trial", "diseases", "baclofen", "analgesia"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032768", "name": "C0032768#ent", "pos": [16, 17]}}
{"token": ["This", "C0003693#ent", "<e1>", "blocked", "by", "preincubation", "of", "the", "platelets", "with", "C0000546#ent", "<e2>", ",", "which", "inhibits", "both", "cyclooxygenase", "and", "lipoxygenase", "."], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000546", "name": "C0000546#ent", "pos": [10, 11]}}
{"token": ["The", "utilization", "of", "iron", "dextran", "investigated", "in", "normal", "subjects", "in", "patients", "with", "iron-deficiency", "anaemia", "and", "in", "C0002871#ent", "<e1>", "associated", "with", "rheumatoid", "arthritis", "reticulosis", ",", "and", "C0041948#ent", "<e2>", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [25, 26]}}
{"token": ["This", "study", "aimed", "to", "assess", "the", "effect", "of", "C0002871#ent", "<e1>", "on", "volume", "related", "hormones", "in", "dialyzed", "patients", "with", "C0041948#ent", "<e2>"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [18, 19]}}
{"token": ["CD146", "(", "S-Endo", "1", "Ag", "or", "C1708808#ent", "<e1>", ")", "is", "a", "C1415205#ent", "<e2>", "expressed", "on", "endothelial", "cells", "the", "whole", "vascular", "tree"], "h": {"id": "C1708808", "name": "C1708808#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415205", "name": "C1415205#ent", "pos": [11, 12]}}
{"token": ["We", "genetically", "inserted", "an", "enterokinase", "(", "EK", ")", "protease", "site", "just", "in", "front", "of", "the", "C1418650#ent", "<e1>", "sequence", "and", "demonstrated", "the", "proteolytical", "liberation", "C1418650#ent", "<e1>", "from", "the", "C1968832#ent", "<e1>"], "h": {"id": "C1418650", "name": "C1418650#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1968832", "name": "C1968832#ent", "pos": [27, 28]}}
{"token": ["Apical", "HCM", "combined", "with", "severe", "C0035067#ent", "<e1>", "very", "rare", "and", "has", "not", "previously", "been", "reported", "with", "C0025239#ent", "<e2>"], "h": {"id": "C0035067", "name": "C0035067#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025239", "name": "C0025239#ent", "pos": [16, 17]}}
{"token": ["C0034063#ent", "<e1>", "a", "classic", "and", "severe", "manifestation", "of", "falciparum", "C0024530#ent", "<e2>", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [9, 10]}}
{"token": ["C0034063#ent", "<e1>", "a", "recognized", "complication", "of", "Plasmodium", "falciparum", "C0024530#ent", "<e2>", "but", "is", "uncommon", "with", "Plasmodium", "vivax", "infection"], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [8, 9]}}
{"token": ["C0002598#ent", "<e1>", "blunted", "the", "heart", "rate", "increase", "produced", "by", "C0022245#ent", "<e2>", "on", "days", "2", "to", "12", "(", "p", "less", "than", "0.05", "versus", "day", "0", ")", "."], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [9, 10]}}
{"token": ["C0039659#ent", "<e1>", "not", "a", "significant", "C0304402#ent", "<e2>", "of", "pepsin", "secretion", "the", "Heidenhain", "pouch.7", "."], "h": {"id": "C0039659", "name": "C0039659#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [5, 6]}}
{"token": ["A", "gastric", "secretory", "study", "which", "C0039659#ent", "<e1>", "was", "used", "as", "the", "C0304402#ent", "<e2>", "revealed", "that", "acid", "and", "pepsin", "secretion", "less", "in", "ALC", "patients", "than", "in", "hospital", "controls", "(", "p", "less", "than", "0.001", ")", "."], "h": {"id": "C0039659", "name": "C0039659#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [11, 12]}}
{"token": ["One", "of", "the", "main", "uses", "of", "erythromycin", "in", "C0877203#ent", "<e1>", "been", "in", "the", "treatment", "of", "C0001361#ent", "<e2>", "an", "alternative", "to", "penicillin", "."], "h": {"id": "C0877203", "name": "C0877203#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001361", "name": "C0001361#ent", "pos": [15, 16]}}
{"token": ["In", "C0362046#ent", "<e1>", "patients", "(", "NN", "and", "C1332712#ent", "<e2>", ")", ",", "LHRH", "induced", "a", "slight", "but", "significant", "rise", "in", "blood", "glucose"], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332712", "name": "C1332712#ent", "pos": [7, 8]}}
{"token": ["Clinical", "efficacy", "fenticonazole", "2", "%", "cream", "has", "been", "tested", "on", "30", "patients", "with", "C0037274#ent", "<e1>", "and", "the", "2", "%", "nebulized", "lotion", "10", "patients", "with", "C0040262#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0040262", "name": "C0040262#ent", "pos": [24, 25]}}
{"token": ["Thirty-six", "patients", "(", "90", "%", ")", "were", "cured", "at", "the", "end", "of", "the", "5-week", "period", ";", "26", "were", "cured", "from", "C0037274#ent", "<e1>", "and", "10", "from", "C0040262#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [20, 21]}, "relation": "nichd_parent_of", "t": {"id": "C0040262", "name": "C0040262#ent", "pos": [25, 26]}}
{"token": ["Three", "of", "the", "citrate-processing", "enzymes", ",", "C0008855#ent", "<e1>", "ATP", "C0001156#ent", "<e2>", "and", "C0001156#ent", "<e2>", "catalyze", "reversible", "aldol-type", "condensations", "."], "h": {"id": "C0008855", "name": "C0008855#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001156", "name": "C0001156#ent", "pos": [9, 10]}}
{"token": ["This", "study", "represents", "the", "first", "report", "of", "the", "involvement", "of", "an", "C1413965#ent", "<e1>", "the", "p53", "response", "and", "highlights", "a", "novel", "mechanism", "by", "which", "C3541312#ent", "<e2>", "may", "act", "as", "a", "tumour", "cosuppressor", "governing", "p53", "transcriptional", "activity"], "h": {"id": "C1413965", "name": "C1413965#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3541312", "name": "C3541312#ent", "pos": [23, 24]}}
{"token": ["Although", "endotoxin", "is", "known", "to", "affect", "C0948245#ent", "<e1>", "these", "endocrine", "effects", "do", "not", "require", "a", "C0127400#ent", "<e2>", "role", "of", "central", "IL-1", "in", "the", "primate", "."], "h": {"id": "C0948245", "name": "C0948245#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [15, 16]}}
{"token": ["Bacteria", "and", "their", "products", "scarcely", "play", "any", "part", "in", "C0038218#ent", "<e1>", "may", "possibly", "aggravate", "chronic", "bronchitis", "other", "forms", "of", "C0035204#ent", "<e2>"], "h": {"id": "C0038218", "name": "C0038218#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [19, 20]}}
{"token": ["Of", "these", ",", "the", "course", "of", "four", "patients", "(", "two", "with", "C0002895#ent", "<e1>", "one", "with", "C0019034#ent", "<e2>", "and", "one", "with", "hemoglobin", "S-Thal", "was", "complicated", "by", "the", "development", "of", "pulmonary", "edema"], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0019034", "name": "C0019034#ent", "pos": [15, 16]}}
{"token": ["Neither", "enzyme", "was", "inhibited", "by", "a", "range", "of", "plausible", "C0016411#ent", "<e1>", "as", "mandelate", ",", "phenylglyoxylate", ",", "benzoate", ",", "C0220918#ent", "<e2>", ",", "acetyl-CoA", ",", "ATP", "or", "ADP", "."], "h": {"id": "C0016411", "name": "C0016411#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220918", "name": "C0220918#ent", "pos": [18, 19]}}
{"token": ["It", "is", "suggested", "that", "a", "depletion", "of", "pituitary", "TSH", "Prl", "stores", "readily", "C0171484#ent", "<e1>", "in", "response", "to", "a", "constant", "dosage", "level", "of", "C1705225#ent", "<e2>", "may", "be", "responsible", "for", "the", "secretory", "patterns", "."], "h": {"id": "C0171484", "name": "C0171484#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [22, 23]}}
{"token": ["In", "our", "previous", "study", "we", "found", "in", "42", "patients", "with", "C0010346#ent", "<e1>", "significantly", "higher", "level", "of", "urinary", "phenol", "C0678201#ent", "<e2>", "ileal", "resection", "compared", "with", "Crohn", "'s", "segmental", "colitis", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0678201", "name": "C0678201#ent", "pos": [18, 19]}}
{"token": ["C1415760#ent", "<e1>", "mRNA", "levels", "in", "MBCs", "from", "patients", "with", "C0022336#ent", "<e2>", "were", "significantly", "higher", "than", "those", "from", "patients", "with", "VD", "or", "PD", "and", "in", "nondemented", "controls", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [9, 10]}}
{"token": ["There", "results", "indicate", "that", "cannabinoid", "receptor", "HU-210", "possesses", "C0007209#ent", "<e1>", "delays", "the", "formation", "of", "necrotic", "zones", "during", "C0151814#ent", "<e2>", "reperfusion", "."], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0151814", "name": "C0151814#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "events", "very", "early", "in", "C0282687#ent", "<e1>", "the", "control", "of", "viral", "replication", "recovery", "or", "C0007397#ent", "<e2>", "death", "."], "h": {"id": "C0282687", "name": "C0282687#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007397", "name": "C0007397#ent", "pos": [15, 16]}}
{"token": ["Recent", "epidemiologic", "studies", "that", "approximately", "40", "to", "50", "%", "of", "stable", "patients", "with", "congestive", "heart", "failure", "C0019099#ent", "<e1>", ")", "suffer", "from", "either", "obstructive", "sleep", "apnea", "SA", ")", "or", "C0008039#ent", "<e2>", "central", "SA"], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008039", "name": "C0008039#ent", "pos": [28, 29]}}
{"token": ["We", "hypothesized", "that", "mortality", "is", "higher", "in", "patients", "with", "congestive", "heart", "failure", "C0019099#ent", "<e1>", ")", "who", "develop", "C0008039#ent", "<e2>", "CSR", ")", "during", "sleep", "than", "C0019099#ent", "<e1>", "patients", "without", "CSR", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008039", "name": "C0008039#ent", "pos": [17, 18]}}
{"token": ["In", "HIV", "infected", "drug-addicts", "it", "comes", "about", "to", "clinically", "asymptomatic", ",", "C0524909#ent", "<e1>", "with", "morphological", "changes", "of", "C0860207#ent", "<e2>"], "h": {"id": "C0524909", "name": "C0524909#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0860207", "name": "C0860207#ent", "pos": [17, 18]}}
{"token": ["Periodontal", "infections", "individuals", "with", "pre-existing", "C0018799#ent", "<e1>", "believed", "to", "increase", "the", "risk", "for", "future", "C1956346#ent", "<e2>", "CHD", ")", "events", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["The", "elevation", "of", "C0041236#ent", "<e1>", "not", "suppressed", "by", "C0050341#ent", "<e2>", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0050341", "name": "C0050341#ent", "pos": [8, 9]}}
{"token": ["Recent", "studies", "suggest", "that", "P-glycoprotein", "(", "Pgp", ")", "encoded", "by", "C0376622#ent", "<e1>", "may", "be", "an", "important", "factor", "in", "the", "pathogenesis", "of", "C0010346#ent", "<e2>", "IBD", ")", "."], "h": {"id": "C0376622", "name": "C0376622#ent", "pos": [10, 11]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [21, 22]}}
{"token": ["However", ",", "pretraining", "bilateral", "intracerebral", "injections", "of", "1.25", "pmole/hemisphere", "omega-conotoxin", "C1706170#ent", "<e1>", "produced", "amnesia", "for", "the", "passive", "avoidance", "C1416596#ent", "<e2>", "in", "chicks", "tested", "30", "min", "or", "3", "h", "after", "training", "."], "h": {"id": "C1706170", "name": "C1706170#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "the", "effects", "of", "selenium", "supplementation", "in", "C0011860#ent", "<e1>", "patients", "on", "several", "oxidative", "stress", "parameters", "and", "C1417708#ent", "<e2>"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [17, 18]}}
{"token": ["Two", "antagonists", "of", "CysLT1", "receptors", "been", "recently", "launched", "on", "the", "market", ":", "ONO-1078", ",", "C0526058#ent", "<e1>", ",", "Onon", "and", "ICI-204,219", ",", "zafirlukast", ",", "C0526502#ent", "<e2>", "."], "h": {"id": "C0526058", "name": "C0526058#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0526502", "name": "C0526502#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "an", "erythrocyte", "esterase", "defect", "C0024141#ent", "<e1>", "patients", "resulted", "in", "reduced", "C0007804#ent", "<e2>", "hydrolyzing", "capacity", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [12, 13]}}
{"token": ["Since", "armadillo", "proteins", "like", "beta-catenin", "and", "APC", ",", "are", "known", "to", "participate", "in", "cellular", "signaling", "C1418615#ent", "<e1>", "may", "function", "as", "a", "mediator", "of", "C1418985#ent", "<e2>", "signaling", "events"], "h": {"id": "C1418615", "name": "C1418615#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418985", "name": "C1418985#ent", "pos": [23, 24]}}
{"token": ["We", "utilized", "the", "yeast", "two-hybrid", "system", "identify", "an", "interacting", "armadillo", "protein", "termed", "C1418615#ent", "<e1>", ",", "that", "binds", "specifically", "to", "the", "hydrophilic", "loop", "C1418985#ent", "<e2>"], "h": {"id": "C1418615", "name": "C1418615#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418985", "name": "C1418985#ent", "pos": [22, 23]}}
{"token": ["C0014130#ent", "<e1>", "more", "common", "among", "women", "with", "C0014547#ent", "<e2>", "than", "among", "normal", "women", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [7, 8]}}
{"token": ["The", "objective", "of", "this", "work", "was", "to", "C1875400#ent", "<e1>", "cultured", "mouse", "cells", "amplified", "C1412179#ent", "<e2>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [13, 14]}}
{"token": ["Pulsed-field", "gel", "electrophoresis", "Southern", "blotting", "analysis", "DNAs", "prepared", "from", "several", "pneumococcal", "serotypes", "that", "only", "those", "clinical", "C1875400#ent", "<e1>", "belonging", "to", "serotype", "3", "the", "C1412179#ent", "<e2>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [23, 24]}}
{"token": ["This", "review", "describes", "the", "expression", "of", "two", "representative", "intragonadal", "C0030956#ent", "<e1>", "that", "may", "influence", "luteal", "regression", "interleukin", "1", "beta", "and", "luteal", "rescue", "(", "C1420453#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420453", "name": "C1420453#ent", "pos": [23, 24]}}
{"token": ["The", "antigen", "recognized", "by", "1F9", "was", "determined", "by", "immunoprecipitation", ",", "C0030956#ent", "<e1>", "identification", "by", "mass", "spectrometry", "and", "cDNA", "cloning", "a", "novel", "START", "(", "C1420453#ent", "<e2>", "lipid", "transfer", "domain-containing", "protein"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420453", "name": "C1420453#ent", "pos": [23, 24]}}
{"token": ["Multiple", "C0812312#ent", "<e1>", "sites", "and", "an", "C0812201#ent", "<e2>", "site", "were", "observed", ",", "but", "the", "CArG", "and", "CArG-like", "boxes", "of", "the", "serum", "response", "element", "absent", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812201", "name": "C0812201#ent", "pos": [6, 7]}}
{"token": ["In", "inbred", "mice", "susceptibility", "to", "C0856727#ent", "<e1>", "conferred", "by", "Lith", "genes", "which", "in", "part", "promote", "C0037036#ent", "<e2>", "of", "cholesterol", "into", "bile", "in", "response", "to", "a", "high-fat/cholesterol/cholic", "acid", "(", "lithogenic", ")", "diet", "."], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037036", "name": "C0037036#ent", "pos": [15, 16]}}
{"token": ["We", "also", "demonstrate", "that", "MDMA", "and", "MDA", ",", "like", "C0015827#ent", "<e1>", "and", "its", "N-deethylated", "metabolite", "C0015827#ent", "<e1>", ",", "elicit", "prolonged", "mitogenic", "responses", "human", "valvular", "interstitial", "cells", "via", "activation", "of", "5-HT2B", "receptors"], "h": {"id": "C0015827", "name": "C0015827#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015827", "name": "C0015827#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "C0872043#ent", "<e1>", "phosphorylation", "by", "several", "other", "C0031727#ent", "<e2>", "and", "autophosphorylation", "have", "recently", "been", "shown", "to", "modulate", "its", "functionality", "."], "h": {"id": "C0872043", "name": "C0872043#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}}
{"token": ["These", "results", "represent", "the", "identification", "of", "the", "C0872043#ent", "<e1>", "phosphorylation", "site", "on", "an", "opioid", "receptor", "the", "first", "time", "and", "demonstrate", "that", "C0872043#ent", "<e1>", "is", "the", "prominent", "C0031727#ent", "<e1>", "responsible", "for", "agonist-induced", "opioid", "receptor", "in", "vivo"], "h": {"id": "C0872043", "name": "C0872043#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [26, 27]}}
{"token": ["Expression", "of", "telomerase-related", "mRNAs", "such", "as", "C0087071#ent", "<e1>", "hTERT", ")", ",", "telomerase", "RNA", "component", "hTERC", ")", ",", "and", "telomeric", "repeat", "binding", "factor", "2", "C1705003#ent", "<e2>", ")", "were", "also", "examined", "."], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705003", "name": "C1705003#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "used", "primary", "cultures", "human", "C0669372#ent", "<e1>", "to", "determine", "if", "certain", "xenochemicals", "could", "regulate", "CYP2E1", "and", "C1828081#ent", "<e2>", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1828081", "name": "C1828081#ent", "pos": [18, 19]}}
{"token": ["Buthionine", "sulfoximine", "decreased", "intracellular", "C1260386#ent", "<e1>", "in", "DU145", "cells", "and", "enhanced", "the", "cytotoxic", "potential", "of", "C0014921#ent", "<e2>", "in", "this", "cell", "line"], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014921", "name": "C0014921#ent", "pos": [15, 16]}}
{"token": ["By", "immunoprecipitation/Western", "blot", "analysis", ",", "C1364818#ent", "<e1>", "was", "consistently", "found", "to", "coimmunoprecipitate", "with", "PS1", "or", "C4255327#ent", "<e2>"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4255327", "name": "C4255327#ent", "pos": [15, 16]}}
{"token": ["T3", "treatment", "resulted", "in", "elevated", "histone", "acetylation", "the", "endogenous", "C3273275#ent", "<e1>", ",", "but", "simultaneous", "expression", "of", "C1706346#ent", "<e2>", "resulted", "in", "significantly", "reduced", "histone", "acetylation", "this", "promoter", ",", "primarily", "through", "the", "recruitment", "of", "HDAC4", "."], "h": {"id": "C3273275", "name": "C3273275#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706346", "name": "C1706346#ent", "pos": [16, 17]}}
{"token": ["Electrophoretic", "studies", "were", "performed", "on", "the", "nasal", "discharge", "such", "C1260880#ent", "<e1>", "patients", "to", "analyze", "its", "protein", "components", "C1412332#ent", "<e2>", "and", "23kD", "protein", "."], "h": {"id": "C1260880", "name": "C1260880#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", "we", "analyzed", "the", "TNSALP", "C0017337#ent", "<e1>", "from", "a", "Japanese", "patient", "with", "C0268412#ent", "<e2>", ",", "his", "parents", ",", "his", "brother", ",", "and", "unrelated", "normal", "controls"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268412", "name": "C0268412#ent", "pos": [14, 15]}}
{"token": ["Accordingly", ",", "our", "data", "show", "that", "when", "differentiation", "is", "stimulated", "C0796355#ent", "<e1>", "is", "upregulated", "while", "C1417167#ent", "<e2>", "and", "c-myc", "are", ",", "coordinately", ",", "downregulated", "."], "h": {"id": "C0796355", "name": "C0796355#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417167", "name": "C1417167#ent", "pos": [15, 16]}}
{"token": ["TCR", "[", "alphaE1", "-", "2", "]", "activity", "was", "partially", "(", "40", "%", ")", "inhibited", "by", "C0796355#ent", "<e1>", "but", "not", "at", "all", "by", "C1417167#ent", "<e2>", "."], "h": {"id": "C0796355", "name": "C0796355#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417167", "name": "C1417167#ent", "pos": [22, 23]}}
{"token": ["Contrary", "to", "previous", "findings", "with", "men", ",", "a", "dose-dependent", "effect", "of", "C0001962#ent", "<e1>", "was", "not", "found", "during", "the", "social", "interaction", "C1416596#ent", "<e2>", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [20, 21]}}
{"token": ["The", "impact", "of", "C0001962#ent", "<e1>", "on", "perseverative", "behavior", "examined", "with", "an", "n-back", "working", "memory", "C1416596#ent", "<e2>", "that", "included", "manipulations", "of", "C1416596#ent", "<e2>", "complexity", "and", "prepotency", "of", "inclinations", "to", "respond", "or", "withhold", "responding", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [14, 15]}}
{"token": ["Results", "demonstrated", "that", "heavy", "drinkers", "but", "not", "light", "drinkers", ",", "were", "faster", "to", "approach", "than", "avoid", "C0001962#ent", "<e1>", "the", "SRC", "C1416596#ent", "<e2>", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [20, 21]}}
{"token": ["Human", "salivary", "alpha-amylase", "C0304925#ent", "<e1>", ")", "is", "a", "major", "C1332754#ent", "<e2>", "of", "saliva", "and", "has", "important", "biological", "functions", "including", "the", "initial", "digestion", "of", "starch", "."], "h": {"id": "C0304925", "name": "C0304925#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [9, 10]}}
{"token": ["A", "randomised", "controlled", "trial", "performed", "to", "assess", "hub", "colonisation", "affecting", "positive-pressure", "valve", "connectors", "(", "PPVCs", ")", "compared", "to", "conventional", "C1413079#ent", "<e1>", "used", "for", "radial", "arterial", "catheters", "into", "C0010340#ent", "<e2>", "patients", "."], "h": {"id": "C1413079", "name": "C1413079#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010340", "name": "C0010340#ent", "pos": [27, 28]}}
{"token": ["Isoprenaline", "activated", "C0001492#ent", "<e1>", "similarly", "affected", "whilst", "other", "sarcolemma", "marker", "C3540790#ent", "<e2>", "were", "unaffected", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [10, 11]}}
{"token": ["The", "results", "thus", "show", "that", "the", "C1707615#ent", "<e1>", "to", "the", "C1415505#ent", "<e2>", "identified", "by", "the", "hdc", "mutants", ",", "and", "that", "mutations", "in", "the", "gene", "disrupt", "photoreceptor", "synaptic", "transmission", "."], "h": {"id": "C1707615", "name": "C1707615#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415505", "name": "C1415505#ent", "pos": [10, 11]}}
{"token": ["The", "results", "thus", "show", "that", "the", "C1707615#ent", "<e1>", "to", "the", "histidine", "decarboxylase", "gene", "identified", "by", "the", "C1415505#ent", "<e2>", "mutants", ",", "and", "that", "mutations", "in", "the", "gene", "disrupt", "photoreceptor", "synaptic", "transmission", "."], "h": {"id": "C1707615", "name": "C1707615#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415505", "name": "C1415505#ent", "pos": [16, 17]}}
{"token": ["Recombination", "at", "C0812246#ent", "<e1>", "was", "eliminated", "by", "a", "C3539698#ent", "<e2>", "mutation", ",", "reflecting", "the", "role", "of", "RecA", "in", "SCE", "and", "virtually", "all", "homologous", "recombination", "E.", "coli"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539698", "name": "C3539698#ent", "pos": [8, 9]}}
{"token": ["There", "were", "no", "apparent", "relationships", "between", "SCC", "or", "C1425074#ent", "<e1>", "and", "incidence", "of", "C0036117#ent", "<e2>", "or", "L.", "monocytogenes"], "h": {"id": "C1425074", "name": "C1425074#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "because", "C0101767#ent", "<e1>", "did", "not", "block", "the", "postganglionic", "responses", "elicited", "by", "cholinergic", "nicotinic", "C0003385#ent", "<e2>", "the", "inhibitory", "effects", "of", "C0101767#ent", "<e1>", "must", "be", "mediated", "by", "a", "presynaptic", "action", "on", "cholinergic", "nerve", "terminals"], "h": {"id": "C0101767", "name": "C0101767#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003385", "name": "C0003385#ent", "pos": [15, 16]}}
{"token": ["The", "involvement", "of", "C0033640#ent", "<e1>", "PKA", ",", "PKC", "and", "C1705341#ent", "<e2>", ")", "in", "nitric", "oxide", "apoptosis", "with", "sodium", "nitroprusside", "N-acetyl-L-cysteine", "in", "the", "IPLB-LdFB", "cell", "line", "from", "the", "insect", "Lymantria", "dispar", "investigated", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [9, 10]}}
{"token": ["In", "an", "8-week", "surgical", "scrub", "study", "equal", "effectiveness", "was", "shown", "between", "C0003205#ent", "<e1>", "a", "standard", "3", "%", "C0019435#ent", "<e2>"], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [11, 12]}, "relation": "therapeutic_class_of", "t": {"id": "C0019435", "name": "C0019435#ent", "pos": [17, 18]}}
{"token": ["The", "statistical", "analysis", "correlation", "showed", "positive", "resistance", "between", "C0003205#ent", "<e1>", "(", "cetrimide", ",", "chlorhexidine", ",", "C0019435#ent", "<e2>", ")", "or", "between", "these", "C0003205#ent", "<e1>", "and", "antibiotics", "for", "S", "marcescens", "Alcaligenes", "."], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [8, 9]}, "relation": "therapeutic_class_of", "t": {"id": "C0019435", "name": "C0019435#ent", "pos": [15, 16]}}
{"token": ["PGHS", "peroxidase", "(", "C1418945#ent", "<e1>", ")", "activity", "reduces", "PGG2", "to", "C0033551#ent", "<e2>", "."], "h": {"id": "C1418945", "name": "C1418945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [10, 11]}}
{"token": ["Fatty", "acid", "oxidation", "therefore", "lower", "during", "low-intensity", "physical", "activity", "C3810616#ent", "<e1>", ",", "LAA", ",", "and", "C3539565#ent", "<e2>", "than", "in", "LC", "women", "."], "h": {"id": "C3810616", "name": "C3810616#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539565", "name": "C3539565#ent", "pos": [15, 16]}}
{"token": ["There", "appears", "to", "be", "a", "higher", "rate", "of", "C0024440#ent", "<e1>", "the", "intracapsular", "technique", "a", "higher", "rate", "of", "C0474441#ent", "<e2>", "the", "extracapsular", "technique"], "h": {"id": "C0024440", "name": "C0024440#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0474441", "name": "C0474441#ent", "pos": [17, 18]}}
{"token": ["Ca(2+)-mobilizing", "reagents", "such", "as", "thapsigargin", "and", "the", "C0001477#ent", "<e1>", "ionophore", "A23187", "mimicked", "the", "effect", "of", "C0600370#ent", "<e2>", "on", "NO", "generation", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "report", "that", ",", "in", "mice", ",", "HSF1", "deficiency", "reduces", "cardiac", "expression", "C1333928#ent", "<e1>", ",", "alphaB-crystallin", "and", "Hsp70", ",", "but", "not", "C3538704#ent", "<e2>", "and", "Hsp90", "."], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [22, 23]}}
{"token": ["p85", "represses", "the", "basal", "activity", "C2987236#ent", "<e1>", "in", "the", "absence", "of", "C0812325#ent", "<e2>", "."], "h": {"id": "C2987236", "name": "C2987236#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [11, 12]}}
{"token": ["A", "constitutively", "activated", "mutant", ",", "C2987236#ent", "<e1>", ",", "that", "functions", "independently", "of", "C0812325#ent", "<e2>", "stimulation", "was", "constructed", "to", "determine", "the", "specific", "responses", "regulated", "by", "Pl-3", "kinase", "."], "h": {"id": "C2987236", "name": "C2987236#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [12, 13]}}
{"token": ["The", "hereditary", "prostate", "cancer", "1", "HPC1", ")", "allele", "maps", "to", "the", "C1419413#ent", "<e1>", "gene", "encoding", "a", "protein", "(", "C0071795#ent", "<e2>", "implicated", "in", "the", "antiviral", "activity", "interferons", "."], "h": {"id": "C1419413", "name": "C1419413#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0071795", "name": "C0071795#ent", "pos": [18, 19]}}
{"token": ["Naloxone", "and", "ketanserin", "did", "not", "affect", "the", "C0720099#ent", "<e1>", "of", "nociceptive", "behaviour", "animals", "not", "treated", "with", "C2350083#ent", "<e2>", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2350083", "name": "C2350083#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "the", "same", "protein", "was", "immunoprecipitated", "from", "an", "Epstein-Barr", "virus-infected", "Burkitt", "'s", "lymphoma", "cell", "line", "which", "expressed", "C0919478#ent", "<e1>", "mRNA", "but", "not", "in", "its", "uninfected", "C0919478#ent", "<e1>", "mRNA-negative", "counterpart", "."], "h": {"id": "C0919478", "name": "C0919478#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0919478", "name": "C0919478#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "ARE", "activation", "by", "C1833296#ent", "<e1>", "was", "inhibited", "by", "antioxidants", "or", "C1413138#ent", "<e2>", "."], "h": {"id": "C1833296", "name": "C1833296#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [13, 14]}}
{"token": ["This", "study", "suggested", "that", "in", "C3495559#ent", "<e1>", "hip", "involvement", "was", "more", "frequent", "in", "C3495919#ent", "<e2>", "polyarticular", "subtypes", "."], "h": {"id": "C3495559", "name": "C3495559#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C3495919", "name": "C3495919#ent", "pos": [13, 14]}}
{"token": ["Thus", "patients", "addition", "of", "C0070166#ent", "<e1>", "to", "aspirin", "and", "thrombolysis", "with", "C0038418#ent", "<e2>", "was", "associated", "with", "myocardial", "contractile", "function", "lower", "mortality", "due", "to", "acute", "heart", "failure"], "h": {"id": "C0070166", "name": "C0070166#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038418", "name": "C0038418#ent", "pos": [11, 12]}}
{"token": ["The", "increase", "in", "TNF", "levels", "by", "C1260235#ent", "<e1>", "blocked", "by", "co-administration", "of", "the", "C3850168#ent", "<e2>", "tamoxifen", "."], "h": {"id": "C1260235", "name": "C1260235#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3850168", "name": "C3850168#ent", "pos": [13, 14]}}
{"token": ["A", "4-amino", "acid", "sequence", "INAL", "70", "-", "73", ")", "expressed", "in", "CFTR", "shares", "50", "%", "homology", "to", "the", "C1415151#ent", "<e1>", "inhibitory", "peptide", ",", "but", "it", "does", "not", "bind", "C0257694#ent", "<e2>"], "h": {"id": "C1415151", "name": "C1415151#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0257694", "name": "C0257694#ent", "pos": [28, 29]}}
{"token": ["These", "symptoms", "were", "less", "severe", "than", "those", "of", "C0017160#ent", "<e1>", "by", "group", "A", "C0035869#ent", "<e2>"], "h": {"id": "C0017160", "name": "C0017160#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0035869", "name": "C0035869#ent", "pos": [13, 14]}}
{"token": ["A", "therapy", "with", "C0038317#ent", "<e1>", "was", "initiated", "which", "induced", "a", "complete", "remission", "of", "the", "C1704321#ent", "<e2>"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [14, 15]}}
{"token": ["The", "C0079429#ent", "<e1>", "encoding", "the", "proton-glutamate", "carrier", "(", "C1825375#ent", "<e2>", ")", "of", "Escherichia", "coli", "K-12", "sequenced", ",", "and", "the", "primary", "structure", "the", "protein", "was", "analyzed", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1825375", "name": "C1825375#ent", "pos": [8, 9]}}
{"token": ["This", "study", "aims", "to", "test", "the", "lymphocyte", "response", "normal", "subjects", "patients", "who", "presented", "an", "anaphylactoid", "shock", "various", "anaesthetic", "and", "C0358430#ent", "<e1>", "by", "using", "the", "lymphoblast", "transformation", "test", "C4287739#ent", "<e2>", ")", "."], "h": {"id": "C0358430", "name": "C0358430#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4287739", "name": "C4287739#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", "to", "the", "RYR1", "C0597298#ent", "<e1>", ",", "the", "cardiac", "RYR2", "C0597298#ent", "<e1>", "was", "unaffected", "by", "C0010977#ent", "<e1>", ",", "both", "in", "native", "cardiac", "SR", "vesicles", "and", "when", "heterologously", "expressed", "in", "HEK-293", "cells", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010977", "name": "C0010977#ent", "pos": [16, 17]}}
{"token": ["Oral", "hygiene", "standards", "gingival", "health", "probing", "depth", "clinical", "attachment", "level", "C0017572#ent", "<e1>", "tooth", "vitality", "and", "detectable", "C0333519#ent", "<e2>", "or", "root", "resorption", "also", "recorded", "."], "h": {"id": "C0017572", "name": "C0017572#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0333519", "name": "C0333519#ent", "pos": [16, 17]}}
{"token": ["McH/lpr-RA1", "mice", "may", "provide", "a", "new", "insight", "into", "the", "study", "of", "C0003873#ent", "<e1>", "regarding", "the", "common", "genomic", "spectrum", "seronegative", "C0003873#ent", "<e1>", "and", "C0242490#ent", "<e1>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242490", "name": "C0242490#ent", "pos": [22, 23]}}
{"token": ["IL-6(-/-", ")", "animals", "expressed", "normal", "levels", "of", "C0613488#ent", "<e1>", "mRNA", "in", "C0023899#ent", "<e2>", ",", "with", "Exon", "H-containing", "transcripts", "remaining", "the", "predominant", "mRNA", "isoform", "."], "h": {"id": "C0613488", "name": "C0613488#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}}
{"token": ["C1857820#ent", "<e1>", "represents", "the", "second", "ARNSHI", "locus", "to", "map", "to", "C0795843#ent", "<e2>"], "h": {"id": "C1857820", "name": "C1857820#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0795843", "name": "C0795843#ent", "pos": [10, 11]}}
{"token": ["The", "drugs", "that", "seem", "to", "have", "the", "highest", "incidence", "of", "osteochemionecrosis", "are", ":", "C1883607#ent", "<e1>", ",", "pamidronate", ",", "alendronate", ",", "C0246719#ent", "<e2>", "and", "ibandronate", ",", "from", "the", "greatest", "to", "the", "least", "."], "h": {"id": "C1883607", "name": "C1883607#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0246719", "name": "C0246719#ent", "pos": [20, 21]}}
{"token": ["Following", "tsetse-transmitted", "infection", "no", "significant", "were", "observed", "between", "breeds", "in", "the", "development", ",", "C2926735#ent", "<e1>", "and", "size", "of", "the", "C0007939#ent", "<e2>", "in", "the", "degree", "and", "C2926735#ent", "<e1>", "of", "parasitaemia", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007939", "name": "C0007939#ent", "pos": [19, 20]}}
{"token": ["Phosphatidylinositol", "3-kinase", "C0285558#ent", "<e1>", "activated", "by", "insulin", "but", "not", "by", "C0256103#ent", "<e2>", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [10, 11]}}
{"token": ["It", "is", "known", "that", "sheep", "show", "polymorphism", "for", "haemoglobin", "in", "that", "three", "phenotypes", "(", "C3538758#ent", "<e1>", ",", "HbB", "AND", "C3540507#ent", "<e2>", ")", "are", "normally", "found", "."], "h": {"id": "C3538758", "name": "C3538758#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540507", "name": "C3540507#ent", "pos": [19, 20]}}
{"token": ["After", "isolation", "of", "the", "micellar", "phases", ",", "no", "triglycerides", "recovered", ",", "but", "fatty", "acids", "C0017860#ent", "<e1>", "the", "hydrolysed", "C0041073#ent", "<e2>", "and", "dietary", "phosphatidylcholines", "small", "quantities", "lyso-phosphatidylcholines", "(", "hydrolysed", "forms", ")", "were", "present", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0041073", "name": "C0041073#ent", "pos": [18, 19]}}
{"token": ["C0017860#ent", "<e1>", "tested", "included", "C0041073#ent", "<e2>", ",", "dilinolein", ",", "diarachidonin", ",", "oleoyl-acetyl-glycerol", ",", "dioctonoyl-sn-glycerol", ",", "dipalmitin", "and", "distearin", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041073", "name": "C0041073#ent", "pos": [4, 5]}}
{"token": ["Four", "C0017860#ent", "<e1>", "have", "been", "tested", ":", "1,2-dioctanoylglycerol", ";", "1,2-dicaprylglycerol", ";", "C0041073#ent", "<e2>", ";", "and", "1-oleoyl-2-acetoyl-sn-3-glycerol", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041073", "name": "C0041073#ent", "pos": [11, 12]}}
{"token": ["Beta-adrenoceptor", "blockade", "is", "an", "effective", "treatment", "for", "ischemic", "heart", "disease", "hypertension", ",", "but", "the", "more", "widespread", "use", "of", "C0001645#ent", "<e1>", "limited", "by", "their", "bronchoconstrictor", ",", "C4255305#ent", "<e2>", "and", "negative", "inotropic", "properties"], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [25, 26]}}
{"token": ["Ongoing", "vigilance", "is", "required", ",", "however", ",", "for", "complications", "that", "can", "arise", "in", "C-ADM", "patients", "including", "potentially", "fatal", "C0206062#ent", "<e1>", "internal", "malignancy", "delayed", "onset", "of", "C0030552#ent", "<e2>", "myositis", ",", "and", "complications", "of", "systemic", "drug", "therapy"], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [25, 26]}}
{"token": ["Comparison", "of", "purified", "RH", "and", "C1826843#ent", "<e1>", "LHCII", "indicated", "no", "significant", "with", "respect", "to", "C1305923#ent", "<e2>", ",", "amino", "acid", "Chl", ",", "and", "carotenoid", "compositions", "as", "well", "as", "no", "differences", "in", "lipid", "content"], "h": {"id": "C1826843", "name": "C1826843#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}}
{"token": ["C1708432#ent", "<e1>", "and", "p19", "were", "identified", "as", "C1416956#ent", "<e2>", "MARCKS", ")", "and", "stathmin", ",", "respectively", ",", "as", "assessed", "by", "their", "two-dimensional", "gel", "electrophoretic", "profiles", "their", "stabilities", "to", "heat", "and", "acid", "treatment", "."], "h": {"id": "C1708432", "name": "C1708432#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416956", "name": "C1416956#ent", "pos": [7, 8]}}
{"token": ["C1708432#ent", "<e1>", "and", "p19", "were", "identified", "as", "myristoylated", "alanine-rich", "C", "kinase", "substrate", "C1416956#ent", "<e2>", ")", "and", "stathmin", ",", "respectively", ",", "as", "assessed", "by", "their", "two-dimensional", "gel", "electrophoretic", "profiles", "their", "stabilities", "to", "heat", "and", "acid", "treatment", "."], "h": {"id": "C1708432", "name": "C1708432#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416956", "name": "C1416956#ent", "pos": [12, 13]}}
{"token": ["After", "incubation", "with", "trichloroacetate", ",", "guanidine-SCN", ",", "guanidine-HCl", ",", "formic", "acid", "C0031428#ent", "<e1>", "and", "autoclaving", ",", "amyloid", "plaques", "unfixed", "frozen", "sections", "human", "brains", "with", "C2347435#ent", "<e2>", "or", "GSS", ",", "lost", "the", "affinity", "of", "Congo", "red", "green", "birefringence", "polarized", "light"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [24, 25]}}
{"token": ["Alterations", "of", "these", "GABA-mediated", "inhibitory", "phenomena", "may", "occur", "in", "C0004303#ent", "<e1>", "with", "aging", "and", "C0036572#ent", "<e2>"], "h": {"id": "C0004303", "name": "C0004303#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "PPAR", "natural", "ligands", "such", "as", "leukotriene", "B4", "C2984537#ent", "<e1>", "15-deoxy-delta", "12,14-prostaglandin", "J2", "for", "PPAR", "gamma", "and", "C0205911#ent", "<e2>", "for", "PPAR", "delta", "are", "known", "to", "be", "eicosanoids", "and", "fatty", "acids"], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [19, 20]}}
{"token": ["Together", ",", "these", "findings", "raise", "the", "possibility", "that", "FSH-mediated", "induction", "of", "C1334077#ent", "<e1>", "and", "resultant", "inhibition", "of", "basic", "C1420632#ent", "<e2>", "genes", "in", "Sertoli", "cells", "contribute", "to", "the", "regulation", "of", "spermatogenesis", "."], "h": {"id": "C1334077", "name": "C1334077#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [18, 19]}}
{"token": ["C0018995#ent", "<e1>", ",", "or", "primary", "iron", "overload", "is", "a", "variably", "expressed", "C0025517#ent", "<e2>", "modified", "by", "sex", ",", "age", ",", "diet", ",", "and", "alcohol", "consumption"], "h": {"id": "C0018995", "name": "C0018995#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [11, 12]}}
{"token": ["Hereditary", "deposition", "iron", "(", "C0018995#ent", "<e1>", "or", "copper", "(", "Wilson's", "disease", "are", "autosomal", "recessive", "C0025517#ent", "<e2>", "by", "progressive", "liver", "pathology", "subsequent", "involvement", "of", "various", "other", "organs", "."], "h": {"id": "C0018995", "name": "C0018995#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [14, 15]}}
{"token": ["Acquired", "isolated", "or", "unitrophic", "C1704793#ent", "<e1>", "deficiency", "is", "a", "rare", "but", "definite", "cause", "of", "C0405580#ent", "<e2>"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [14, 15]}}
{"token": ["Previous", "studies", "have", "shown", "that", "the", "rapid", "C1704793#ent", "<e1>", "stimulation", "test", "a", "low", "dose", "1", "microg", "is", "more", "sensitive", "than", "that", "using", "250", "microg", "C1704793#ent", "<e1>", "for", "detecting", "subtle", "cases", "of", "C0405580#ent", "<e1>"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [31, 32]}}
{"token": ["C0040975#ent", "<e1>", "morphometry", "revealed", "that", "incubation", "with", "500", "micrograms/ml", "C3887654#ent", "<e2>", "retarded", "significantly", "(", "p", "less", "than", "0.001", "at", "days", "2", "and", "3", ")", "the", "loss", "of", "podocyte", "foot", "observed", "in", "control", "cultures"], "h": {"id": "C0040975", "name": "C0040975#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887654", "name": "C3887654#ent", "pos": [9, 10]}}
{"token": ["Finally", ",", "C0009010#ent", "<e1>", "also", "decreased", "C1705401#ent", "<e2>", "expression", "(", "whole-cell", "Western", "blot", "in", "LMCAT", "cells", "(", "50", "%", "reduction", ")", "and", "primary", "rat", "neurones", "(", "80", "%", "reduction", ")", "."], "h": {"id": "C0009010", "name": "C0009010#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [6, 7]}}
{"token": ["We", "show", "that", "conditional", "Purkinje", "C1332691#ent", "<e1>", "ablation", "of", "the", "key", "miRNA-generating", "enzyme", "C1333218#ent", "<e2>", "leads", "to", "Purkinje", "cell", "death"], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333218", "name": "C1333218#ent", "pos": [13, 14]}}
{"token": ["Indeed", ",", "tryptic", "phosphopeptide", "analyses", "of", "metabolically", "(32)P-labeled", "C0028326#ent", "<e1>", "expressed", "in", "the", "presence", "of", "a", "dominant-negative", "mutant", ",", "C1418918#ent", "<e2>", ",", "showed", "a", "lack", "of", "distinct", "C0028326#ent", "<e1>", "phosphorylation", "events", "."], "h": {"id": "C1418918", "name": "C1418918#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0028326", "name": "C0028326#ent", "pos": [8, 9]}}
{"token": ["We", "report", "here", "the", "initial", "experience", "with", "C0678133#ent", "<e1>", "in", "these", "two", "C0029896#ent", "<e2>", "Israel", ",", "at", "three", "institutions", "within", "the", "framework", "of", "large", "multinational", "trials", "."], "h": {"id": "C0678133", "name": "C0678133#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [12, 13]}}
{"token": ["It", "may", "be", "quite", "useful", "for", "surgically", "treating", "C0026946#ent", "<e1>", "and", "other", "C0751003#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [12, 13]}}
{"token": ["However", ",", "now", "the", "term", "\"", "C0026946#ent", "<e1>", "\"", "aneurysm", "is", "applied", "to", "all", "cases", "of", "C0751003#ent", "<e2>", "caused", "by", "any", "organisms", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [16, 17]}}
{"token": ["Because", "infectious", "causative", "agents", "never", "detected", "at", "the", "level", "of", "the", "lesions", ",", "a", "classical", "\"", "C0026946#ent", "<e1>", "\"", "origin", "of", "these", "C0751003#ent", "<e2>", "seemed", "unlikely", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [22, 23]}}
{"token": ["C2825484#ent", "<e1>", "is", "a", "C1254351#ent", "<e2>", "from", "the", "pyrrolidone", "family", "had", "been", "shown", "to", "induce", "non-competitive", "inhibition", "of", "rat", "hydroxymethylglutaryl-coenzyme", "A", "reductase", "in", "vitro"], "h": {"id": "C2825484", "name": "C2825484#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}}
{"token": ["C2825484#ent", "<e1>", "is", "a", "new", "C1254351#ent", "<e2>", "from", "the", "pyrrolidone", "family", "which", "acts", "as", "a", "non-competitive", "inhibitor", "of", "3-hydroxy-3-methylglutaryl-coenzyme", "A", "reductase"], "h": {"id": "C2825484", "name": "C2825484#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [5, 6]}}
{"token": ["The", "minimal", "intensity", "level", "of", "the", "noise", "that", "enabled", "C3640123#ent", "<e1>", "measurement", "was", "20", "dB", "C1420014#ent", "<e2>", "for", "white", "noise", "30", "dB", "C1420014#ent", "<e2>", "for", "low-frequency", "noise", "."], "h": {"id": "C3640123", "name": "C3640123#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420014", "name": "C1420014#ent", "pos": [15, 16]}}
{"token": ["It", "has", "recently", "been", "shown", "that", "chronic", "administration", "a", "Ginkgo", "biloba", "extract", "EGb", "761", ")", "inhibits", "stress-induced", "corticosterone", "C0037036#ent", "<e1>", "through", "a", "reduction", "in", "the", "number", "of", "C1823521#ent", "<e2>"], "h": {"id": "C0037036", "name": "C0037036#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [27, 28]}}
{"token": ["Myosin", "binds", "both", "C0078956#ent", "<e1>", "and", "plasminogen", ",", "and", "enhances", "activation", "of", "C3539688#ent", "<e2>", "-", "77-plasminogen", "by", "C0078956#ent", "<e1>", "but", "not", "by", "urokinase-type", "plasminogen", "activator", "uPA", ")", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539688", "name": "C3539688#ent", "pos": [12, 13]}}
{"token": ["Cells", "lacking", "C1623430#ent", "<e1>", "exhibit", "prolonged", "C3470429#ent", "<e2>", "induction", ",", "whereas", "constitutive", "C1623430#ent", "<e1>", "inhibits", "UV-mediated", "p21", "induction", "."], "h": {"id": "C3470429", "name": "C3470429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [2, 3]}}
{"token": ["In", "the", "present", "study", "we", "show", "that", "the", "Sp1-occupied", "promoter", "region", "transactivation", "of", "the", "C3470429#ent", "<e1>", "promoter", "by", "C1623430#ent", "<e2>", "and", "the", "related", "proteins", "JunB", ",", "JunD", ",", "and", "ATF-2", "."], "h": {"id": "C3470429", "name": "C3470429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [18, 19]}}
{"token": ["A", "murine", "model", "of", "acute", "LPS-induced", "C3714636#ent", "<e1>", "used", "to", "study", "the", "effect", "of", "C1366876#ent", "<e2>", "MAPK", "inhibition", "in", "ongoing", "pulmonary", "inflammation"], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [14, 15]}}
{"token": ["The", "results", "of", "this", "study", "demonstrated", "that", "2", "%", "C0012228#ent", "<e1>", "oral", "ointment", "a", "clinically", "useful", "analgesic", "for", "C0030193#ent", "<e2>", "oral", "lesions", "."], "h": {"id": "C0012228", "name": "C0012228#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [18, 19]}}
{"token": ["Preliminary", "results", "are", "reported", "on", "the", "use", "of", "C0012228#ent", "<e1>", "in", "other", "C0030193#ent", "<e2>"], "h": {"id": "C0012228", "name": "C0012228#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}}
{"token": ["Mutations", "in", "C1416427#ent", "<e1>", "cause", "the", "C1454821#ent", "<e2>", "form", "of", "autosomal", "dominant", "retinitis", "pigmentosa", "and", "are", "a", "rare", "cause", "of", "Leber", "congenital", "amaurosis"], "h": {"id": "C1416427", "name": "C1416427#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1454821", "name": "C1454821#ent", "pos": [6, 7]}}
{"token": ["As", "to", "therapeutic", "possibilities", ",", "C0003364#ent", "<e1>", "most", "suitable", ",", "i.e.", "angiotensin", "converting", "enzyme", "inhibitors", "C3494348#ent", "<e2>", "the", "IInd", "generation", "and", "also", "blockers", "of", "AT1", "receptors"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [15, 16]}}
{"token": ["C0008677#ent", "<e1>", "characterized", "by", "chronic", "mucus", "hypersecretion", "C0010200#ent", "<e2>", ";", "emphysema", "is", "a", "destructive", "process", "the", "alveolar", "spaces"], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [7, 8]}}
{"token": ["With", "increasing", "exposure", "to", "dust", "at", "the", "work", "place", ",", "C0008677#ent", "<e1>", "symptoms", "such", "as", "C0010200#ent", "<e2>", "and", "sputum", "become", "significantly", "more", "frequent", "."], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [15, 16]}}
{"token": ["Clinical", "and", "toxicological", "data", "on", "verapamil", ",", "quinidine", ",", "ajmaline", ",", "C0032899#ent", "<e1>", ",", "mexiletine", "and", "C0003639#ent", "<e2>", "as", "collected", "by", "the", "Austrian", "Poison", "Information", "Center", "PIC", ")", "are", "presented", "in", "this", "paper", "."], "h": {"id": "C0032899", "name": "C0032899#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003639", "name": "C0003639#ent", "pos": [16, 17]}}
{"token": ["Endothelin", "induced", "a", "rapid", "phosphorylation", "of", "the", "C0170168#ent", "<e1>", "and", "increased", "C0009325#ent", "<e2>", "gene", "activity", "freshly", "isolated", "aortas", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "we", "found", "that", "dihydroginsenoside", "Rg3", "suppressed", "phosphorylation", "of", "C0170168#ent", "<e1>", "ERK2", ")", ",", "which", "was", "stimulated", "by", "C0009325#ent", "<e2>", "(", "2.5", "microg", "mL(-1", ")", ")", ",", "but", "not", "of", "p38", "mitogen-activated", "protein", "kinase"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [20, 21]}}
{"token": ["The", "C0720099#ent", "<e1>", "and", "the", "magnitude", "of", "C0752312#ent", "<e2>", "MAPK", ")", "activation", "specifies", "signal", "identity", "and", "thus", "allows", "the", "regulation", "of", "diverse", "cellular", "functions", "the", "same", "kinase", "cascade"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}}
{"token": ["The", "C0720099#ent", "<e1>", "as", "well", "as", "the", "magnitude", "of", "C0752312#ent", "<e2>", "been", "proposed", "to", "regulate", "gene", "expression", "other", "specific", "intracellular", "responses", "in", "individual", "cell", "types"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [9, 10]}}
{"token": ["On", "the", "contrary", ",", "we", "found", "that", "C0080151#ent", "<e1>", "inhibited", "proteasome", "activity", "increase", "C1332737#ent", "<e2>", "protein", "levels"], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [13, 14]}}
{"token": ["Swelling-induced", "activation", "of", "the", "outwardly", "rectifying", "anion", "current", ",", "C3809768#ent", "<e1>", ",", "swell", ",", "is", "modulated", "by", "intracellular", "C1705556#ent", "<e2>", "."], "h": {"id": "C3809768", "name": "C3809768#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [18, 19]}}
{"token": ["Both", "the", "fast", "transient", "inward", "current", "and", "C3809768#ent", "<e1>", ",", "Ca", "evoked", "by", "C1705556#ent", "<e2>", "and", "its", "analogues", "were", "abolished", "by", "the", "nonselective", "P2", "purinoceptor", "antagonist", "suramin", "."], "h": {"id": "C3809768", "name": "C3809768#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [13, 14]}}
{"token": ["ictaluri", "C1416917#ent", "<e1>", "contains", "higher", "amounts", "of", "galactose", "and", "N-acetylgalactosamine", "than", "the", "C1416917#ent", "<e1>", "mutant", "strain", "which", "correlated", "well", "with", "predicted", "functions", "of", "the", "C1417679#ent", "<e1>", "identified", "in", "the", "C1416917#ent", "<e1>", "biosynthesis", "cluster"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1416917", "name": "C1416917#ent", "pos": [1, 2]}}
{"token": ["We", "previously", "reported", "that", "C0057693#ent", "<e1>", "DADS", ")", "and", "diallyl", "trisulfide", "C0002395#ent", "<e2>", ")", "up-regulate", "the", "gene", "expression", "the", "pi", "class", "glutathione", "S-transferase", "GSTP", ")", "and", "that", "an", "enhancer", "element", "GPE", "I", "required", "for", "this", "induction", "."], "h": {"id": "C0057693", "name": "C0057693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [11, 12]}}
{"token": ["Allyl", "sulfides", "e.g.", ",", "C0057693#ent", "<e1>", "DAS", ")", ",", "diallyl", "disulfide", "DADS", ")", ",", "and", "diallyl", "trisulfide", "C0002395#ent", "<e2>", ")", ",", "are", "principal", "constituents", "of", "garlic", "oil"], "h": {"id": "C0057693", "name": "C0057693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [17, 18]}}
{"token": ["Colorectal", "adenocarcinomas", "the", "cervix", "were", "typically", "diffusely", "positive", "with", "CK20", ",", "CEA", ",", "and", "CDX2", ";", "negative", "with", "C3272782#ent", "<e1>", ";", "and", "negative", "or", "focally", "positive", "C1705280#ent", "<e2>", "."], "h": {"id": "C3272782", "name": "C3272782#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [26, 27]}}
{"token": ["We", "found", "that", "alterations", "in", "hippocampal", "gene", "expression", "transthyretin", "(", "C1421224#ent", "<e1>", ")", ",", "calcineurin", ",", "and", "C1417745#ent", "<e2>", "NQO2", ")", "were", "associated", "with", "memory", "deficits", "aged", "animals", "."], "h": {"id": "C1421224", "name": "C1421224#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417745", "name": "C1417745#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "C0018013#ent", "<e1>", "in", "Myanmar", "where", "this", "C0043528#ent", "<e2>", "considered", "as", "non-endemic", "until", "a", "recent", "outbreak", "."], "h": {"id": "C0018013", "name": "C0018013#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [11, 12]}}
{"token": ["Inhibitor", "studies", "with", "PD98059", "and", "staurosporine", "showed", "that", "a", "C0173879#ent", "<e1>", "the", "oxidative", "response", "while", "the", "antioxidant", "signal", "transmitted", "by", "a", "C1414387#ent", "<e2>"], "h": {"id": "C0173879", "name": "C0173879#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [21, 22]}}
{"token": ["We", "describe", "a", "17-year-old", "patient", "with", "a", "documented", "history", "of", "Crohn's", "disease", "CD", ")", "and", "of", "C0027721#ent", "<e1>", "MCNS", ")", "in", "whom", "a", "diagnosis", "of", "T-cell", "acute", "lymphoblastic", "leukemia", "C0812385#ent", "<e2>", ")", "was", "made", "."], "h": {"id": "C0027721", "name": "C0027721#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [29, 30]}}
{"token": ["C2741742#ent", "<e1>", "ADH2", ")", "represents", "a", "highly", "divergent", "class", "of", "C0001942#ent", "<e2>", "found", "in", "liver", "."], "h": {"id": "C2741742", "name": "C2741742#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [10, 11]}}
{"token": ["This", "was", "coincident", "with", "an", "increase", "in", "pyruvate", "decarboxylase", "C2741742#ent", "<e1>", ",", "and", "later", "increases", "in", "C0001942#ent", "<e2>", "EC", "1.1.1.1", ",", "lactate", "dehydrogenase", "EC", "1.1.1.27", ",", "and", "alanine", "amino", "transferase", "EC", "2.6.1.2", ")", "activities", "."], "h": {"id": "C2741742", "name": "C2741742#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [16, 17]}}
{"token": ["C3540579#ent", "<e1>", "encodes", "the", "yeast", "Saccharomyces", "cerevisiae", "of", "the", "mammalian", "C0027203#ent", "<e2>", "."], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["Headaches", ",", "C0004093#ent", "<e1>", "and", "visual", "disorders", "the", "3", "main", "symptoms", "of", "C0020540#ent", "<e2>", "as", "classically", "described", "."], "h": {"id": "C0004093", "name": "C0004093#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020540", "name": "C0020540#ent", "pos": [12, 13]}}
{"token": ["In", "vitro", "of", "C0250960#ent", "<e1>", "was", "demonstrated", "in", "the", "presence", "of", "porcine", "C0014894#ent", "<e2>", "."], "h": {"id": "C0250960", "name": "C0250960#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014894", "name": "C0014894#ent", "pos": [12, 13]}}
{"token": ["The", "material", "is", "soluble", "in", "water", ",", "not", "in", "ether", ",", "benzene", ",", "or", "C0001002#ent", "<e1>", "and", "it", "is", "relatively", "stable", "to", "heat", "and", "C0719425#ent", "<e2>", "."], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0719425", "name": "C0719425#ent", "pos": [24, 25]}}
{"token": ["The", "samples", ",", "deproteinized", "with", "C0001002#ent", "<e1>", "trichloroacetic", "acid", "were", "treated", "in", "the", "C0719425#ent", "<e2>", "with", "10", "vols", "."], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0719425", "name": "C0719425#ent", "pos": [13, 14]}}
{"token": ["C0021167#ent", "<e1>", "due", "to", "C0042075#ent", "<e2>", "not", "always", "be", "treated", "by", "local", "procedures", "the", "anal", "sphincter", "pelvic", "floor"], "h": {"id": "C0021167", "name": "C0021167#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [4, 5]}}
{"token": ["Glucose", "production", "C3811116#ent", "<e1>", ")", "determined", "with", "[6", "-", "3H]-", "and", "C3640996#ent", "<e2>", "agreed", "closely", "."], "h": {"id": "C3811116", "name": "C3811116#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3640996", "name": "C3640996#ent", "pos": [11, 12]}}
{"token": ["However", ",", "digoxin-specific", "C1414528#ent", "<e1>", "was", "more", "than", "20-fold", "more", "potent", "in", "neutralizing", "C0029904#ent", "<e2>", "and", "bufalin", "than", "marinobufagenin", "."], "h": {"id": "C1414528", "name": "C1414528#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [13, 14]}}
{"token": ["C1414925#ent", "<e1>", "activity", "was", "examined", "in", "rat", "and", "rabbit", "C0001002#ent", "<e2>", "powders", ",", "stabilized", "with", "pyridoxal", "phosphate", "glutathione", "."], "h": {"id": "C1414925", "name": "C1414925#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [9, 10]}}
{"token": ["At", "P10", ",", "the", "NO", "synthase", "NOS", ")", "inhibitor", ",", "C0068821#ent", "<e1>", "(", "LNA", ")", ",", "increased", "severity", "of", "C0036572#ent", "<e2>", "while", "l-arginine", "(", "l-Arg", ")", ",", "the", "NOS", "substrate", ",", "had", "no", "effect"], "h": {"id": "C0068821", "name": "C0068821#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [19, 20]}}
{"token": ["On", "all", "substrates", "C0694888#ent", "<e1>", "produced", "the", "MMPS", ",", "gelatinase-A", "and", "-B", "and", "C0962754#ent", "<e2>", "with", "an", "apparent", "increase", "in", "gelatinase-A", "and", "-B", "production", "when", "cultured", "on", "LN", "."], "h": {"id": "C0694888", "name": "C0694888#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [13, 14]}}
{"token": ["Allergic", "rhinitis", "also", "known", "as", "C0018621#ent", "<e1>", "rose", "fever", "or", "C1384493#ent", "<e2>", "is", "a", "major", "challenge", "to", "health", "professionals"], "h": {"id": "C0018621", "name": "C0018621#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1384493", "name": "C1384493#ent", "pos": [10, 11]}}
{"token": ["Our", "case", "demonstrates", "that", "different", "arteries", "can", "affect", "the", "C0152177#ent", "<e1>", "and", "facial", "nerve", "a", "stage", "that", "precedes", "compression", "by", "a", "C0042568#ent", "<e2>"], "h": {"id": "C0152177", "name": "C0152177#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042568", "name": "C0042568#ent", "pos": [21, 22]}}
{"token": ["We", "demonstrated", "that", "LatB", "decreases", "C1420400#ent", "<e1>", "SRF", ")", "activity", "as", "determined", "by", "C0206414#ent", "<e2>", "whereas", "Jasp", "increases", "SRF", "activity", "."], "h": {"id": "C1420400", "name": "C1420400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0206414", "name": "C0206414#ent", "pos": [13, 14]}}
{"token": ["A", "whole-genome", "scan", "using", "an", "affected", "paternal", "half-sib", "design", "was", "utilized", "to", "detect", "quantitative", "trait", "loci", "C3826857#ent", "<e1>", ")", "for", "left-sided", "displaced", "abomasum", "(", "C0267243#ent", "<e2>", ")", "in", "German", "Holsteins", "."], "h": {"id": "C3826857", "name": "C3826857#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0267243", "name": "C0267243#ent", "pos": [24, 25]}}
{"token": ["Several", "experimental", "autoimmune", "diseases", "C1421876#ent", "<e1>", ")", ",", "including", "allergic", "encephalomyelitis", "ie", "the", "multiple", "sclerosis", "C0026769#ent", "<e2>", ")", "model", ",", "respond", "to", "TBI", "and", "chemotherapy", "followed", "by", "BMT", "."], "h": {"id": "C1421876", "name": "C1421876#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [15, 16]}}
{"token": ["A", "serotonin", "agonist", "MK-212", "(", "0.01", "mg/kg", ")", ",", "antagonized", "whereas", "the", "C0036753#ent", "<e1>", "cyproheptadine", "(", "0.01", "mg/kg", ")", ",", "potentiated", "the", "effects", "of", "C0006462#ent", "<e2>", "without", "having", "behavioral", "effects", "of", "their", "own", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006462", "name": "C0006462#ent", "pos": [24, 25]}}
{"token": ["On", "a", "chronic", "treatment", "C0016860#ent", "<e1>", "and", "dietary", "sodium", "chloride", "restriction", "correction", "of", "hyperchloremic", "acidosis", "hypophosphatemia", "and", "C0035579#ent", "<e2>", "was", "achieved", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [17, 18]}}
{"token": ["This", "experience", "has", "led", "us", "to", "the", "more", "cautions", "use", "of", "C0016860#ent", "<e1>", "and", "sodium", "bicarbonate", "infants", "at", "risk", "for", "C0035579#ent", "<e2>", ",", "and", "shows", "the", "need", "to", "ensure", "daily", "vitamin", "D", "supplements", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [20, 21]}}
{"token": ["Evidence", "is", "accumulating", "from", "several", "laboratories", "that", "at", "least", "one", "of", "these", "C0035064#ent", "<e1>", "under", "investigation", ",", "C0055147#ent", "<e2>", ",", "may", "be", "effective", "in", "inhibiting", "the", "late", "reaction"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0055147", "name": "C0055147#ent", "pos": [17, 18]}}
{"token": ["The", "phenomenon", "of", "exon", "skipping", "induced", "by", "nonsense", "mutations", "been", "described", "for", "other", "disease", "genes", "including", "the", "CFTR", "(", "cystic", "fibrosis", "transmembrance", "conductance", "regulator", "C0017337#ent", "<e1>", "and", "the", "C1414543#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1414543", "name": "C1414543#ent", "pos": [28, 29]}}
{"token": ["Although", "nonsense", "mutations", "been", "associated", "with", "skipping", "of", "specific", "constitutively", "spliced", "exons", "selected", "C0017337#ent", "<e1>", ",", "notably", "the", "C1414543#ent", "<e2>", "the", "basis", "for", "this", "association", "is", "unclear", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414543", "name": "C1414543#ent", "pos": [18, 19]}}
{"token": ["In", "vitro", "experiments", "reveal", "that", "C0022643#ent", "<e1>", "is", "a", "poor", "C3826984#ent", "<e2>", "."], "h": {"id": "C0022643", "name": "C0022643#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3826984", "name": "C3826984#ent", "pos": [10, 11]}}
{"token": ["In", "these", "cases", ",", "the", "expression", "of", "PKHD1", "(", "polycystic", "kidney", "hepatic", "disease", "1", "and", "C1421351#ent", "<e1>", "(", "Uromodulin", ")", ",", "two", "genes", "regulated", "by", "C2348633#ent", "<e2>", ",", "was", "turned", "off", "."], "h": {"id": "C1421351", "name": "C1421351#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2348633", "name": "C2348633#ent", "pos": [25, 26]}}
{"token": ["Co-localization", "of", "C1414905#ent", "<e1>", "with", "both", "Fos-B", "and", "C1706383#ent", "<e2>", "was", "found", "in", "neuronal", "cell", "layers", "of", "the", "hippocampus", "in", "kainate-treated", "animals", "."], "h": {"id": "C1414905", "name": "C1414905#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [8, 9]}}
{"token": ["Dominant-negative", "mutants", "of", "C1414905#ent", "<e1>", "and", "Maf", ",", "but", "not", "of", "C1706383#ent", "<e2>", "and", "c-Jun", ",", "inhibited", "basal", "and", "heme-induced", "expression", "of", "an", "E1-controlled", "luciferase", "gene", "."], "h": {"id": "C1414905", "name": "C1414905#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [11, 12]}}
{"token": ["Transfected", "myoblasts", "proliferated", "in", "response", "to", "C1706440#ent", "<e1>", "(", "comparable", "with", "basic", "fibroblast", "growth", "factor", "C1522505#ent", "<e2>", ")", "treatment", ")", ",", "whereas", "the", "C1706440#ent", "<e1>", "had", "no", "effect", "non-transfected", "cells", "."], "h": {"id": "C1706440", "name": "C1706440#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1522505", "name": "C1522505#ent", "pos": [15, 16]}}
{"token": ["Anti-HCV", "positivity", "was", "related", "to", "blood", "transfusion", ",", "past", "or", "current", "elevations", "of", "C0004002#ent", "<e1>", ",", "to", "a", "lesser", "degree", ",", "C0022661#ent", "<e2>", "duration", "."], "h": {"id": "C0004002", "name": "C0004002#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [21, 22]}}
{"token": ["No", "conversion", "of", "C0259419#ent", "<e1>", "to", "active", "C1453171#ent", "<e2>", "was", "detected", "in", "this", "study", "."], "h": {"id": "C0259419", "name": "C0259419#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1453171", "name": "C1453171#ent", "pos": [7, 8]}}
{"token": ["The", "predicted", "aa", "sequence", "rat", "C0259419#ent", "<e1>", "is", "highly", "similar", "to", "that", "of", "mouse", "C1453171#ent", "<e2>", "(", "97.3", "%", ")", "and", "human", "Ich-1L", "(", "91.3", "%", ")", "."], "h": {"id": "C0259419", "name": "C0259419#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1453171", "name": "C1453171#ent", "pos": [14, 15]}}
{"token": ["Deletion", "of", "the", "phage", "DNA", "segment", "adjacent", "to", "the", "attP", "site", "from", "the", "attP-attB", "constructions", "eliminated", "detectable", "recombination", ",", "suggesting", "that", "this", "sequence", "contains", "the", "C0017337#ent", "<e1>", "encoding", "the", "C0082874#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0082874", "name": "C0082874#ent", "pos": [29, 30]}}
{"token": ["We", "have", "adapted", "the", "DamID", "method", "to", "systematically", "identify", "target", "C0017337#ent", "<e1>", "of", "the", "heterochromatin", "proteins", "C0082874#ent", "<e2>", "and", "SUV39H1", "in", "human", "and", "mouse", "cells"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0082874", "name": "C0082874#ent", "pos": [16, 17]}}
{"token": ["Amiodarone", "(", "0.01", "-", "10", "microM", ")", ",", "C0766326#ent", "<e1>", "(", "0.01", "-", "1", "microM", ")", "and", "C0042523#ent", "<e2>", "(", "0.01", "-", "10", "microM", ")", "induced", "concentration-dependent", "decreases", "in", "coronary", "perfusion", "pressure"], "h": {"id": "C0766326", "name": "C0766326#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [17, 18]}}
{"token": ["Six", "patients", "with", "symptomatic", "heart", "failure", "to", "C0878544#ent", "<e1>", "treated", "surgically", "with", "C1704975#ent", "<e2>", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704975", "name": "C1704975#ent", "pos": [12, 13]}}
{"token": ["In", "C1704799#ent", "<e1>", "patients", ",", "L1", "was", "the", "commonest", ",", "followed", "by", "C1418789#ent", "<e2>", "and", "L3", "respectively", "."], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418789", "name": "C1418789#ent", "pos": [12, 13]}}
{"token": ["E.", "coli", "C0012883#ent", "<e1>", "a", "monomeric", "light-harvesting", "enzyme", "utilizes", "a", "C1417420#ent", "<e2>", "(", "MTHF", ")", "antenna", "cofactor", "to", "harvest", "light", "energy", "the", "repair", "of", "thymine", "dimers", "DNA", "."], "h": {"id": "C0012883", "name": "C0012883#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417420", "name": "C1417420#ent", "pos": [10, 11]}}
{"token": ["In", "addition", "a", "gradual", "change", "of", "C0037274#ent", "<e1>", "be", "observed", ",", "e.g.", ",", "classical", "and", "C0001752#ent", "<e2>", "myxoma", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001752", "name": "C0001752#ent", "pos": [15, 16]}}
{"token": ["Japanese", "flounder", "C1413947#ent", "<e1>", "found", "to", "be", "1561", "bp", "in", "length", "(", "C3715179#ent", "<e2>", "of", "1041", "bp", ")", ",", "encoding", "for", "347", "amino", "acids", "a", "calculated", "molecular", "weight", "39", "kDa", "."], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3715179", "name": "C3715179#ent", "pos": [12, 13]}}
{"token": ["This", "case", "report", "C0031315#ent", "<e1>", "four", "adults", "with", "C4055195#ent", "<e2>"], "h": {"id": "C0031315", "name": "C0031315#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4055195", "name": "C4055195#ent", "pos": [8, 9]}}
{"token": ["In", "previous", "papers", "we", "reported", "that", "nucleotide", "pyrophosphatase", "C0028189#ent", "<e1>", ")", "activities", "are", "markedly", "elevated", "in", "skin", "fibroblasts", "patients", "with", "C0039082#ent", "<e2>"], "h": {"id": "C0028189", "name": "C0028189#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [20, 21]}}
{"token": ["Statistical", "modeling", "the", "mathematics", "to", "use", "data", "from", "large", "numbers", "of", "C1564140#ent", "<e1>", "generate", "information", "about", "hypotheses", "concerning", "C1510464#ent", "<e2>", "easily", "obtained", "from", "anecdotal", "studies", "on", "small", "numbers", "of", "mutants", "."], "h": {"id": "C1564140", "name": "C1564140#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1510464", "name": "C1510464#ent", "pos": [18, 19]}}
{"token": ["CD", "spectra", "of", "these", "C1564140#ent", "<e1>", "that", "the", "alteration", "did", "not", "adversely", "affect", "the", "C1510464#ent", "<e2>"], "h": {"id": "C1564140", "name": "C1564140#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1510464", "name": "C1510464#ent", "pos": [14, 15]}}
{"token": ["Cerebella", "treated", "with", "cAMP", "antisera", ",", "however", ",", "showed", "immunoreactivity", "in", "Purkinje", "cells", "granule", "cells", "and", "C1423498#ent", "<e1>", "addition", "to", "neuroglia", "in", "C0001614#ent", "<e2>", "and", "deep", "nuclei"], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [22, 23]}}
{"token": ["PGOE", "and", "C1427962#ent", "<e1>", "showed", "less", "evidence", "of", "habituation", "than", "did", "C1707081#ent", "<e2>", "and", "OR", "."], "h": {"id": "C1427962", "name": "C1427962#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1707081", "name": "C1707081#ent", "pos": [11, 12]}}
{"token": ["By", "utilizing", "domain", "swapping", "and", "site-directed", "mutagenesis", "have", "found", "that", "the", "C0056248#ent", "<e1>", "beta4-beta5", "strands", "of", "C1514773#ent", "<e2>", "contributes", "to", "high", "affinity", "receptor", "binding", "and", "is", "critical", "for", "KGFR", "recognition", "."], "h": {"id": "C0056248", "name": "C0056248#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1514773", "name": "C1514773#ent", "pos": [16, 17]}}
{"token": ["C0163657#ent", "<e1>", "an", "essential", "trace", "element", "is", "recommended", "for", "C0011849#ent", "<e2>", "and", "also", "has", "been", "reported", "to", "benefit", "depression", ",", "but", "its", "mechanism", "is", "still", "debated", "."], "h": {"id": "C0163657", "name": "C0163657#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["C0008489#ent", "<e1>", ",", "hemichorea", ",", "hemiballismus", "and", "other", "parkinsonian", "C0026650#ent", "<e2>", "been", "described", "in", "type", "1", "diabetic", "patient", "with", "uncontrolled", "hyperglycemia", "."], "h": {"id": "C0008489", "name": "C0008489#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [9, 10]}}
{"token": ["These", "included", ":", "niflumic", "and", "C0016282#ent", "<e1>", "picrotoxin", ",", "5-nitro-2-(-3-phenylpropylamino)benzoic", "acid", "(", "NPPB", ")", ",", "and", "C0057911#ent", "<e2>", "DNDS", ")", "."], "h": {"id": "C0016282", "name": "C0016282#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0057911", "name": "C0057911#ent", "pos": [16, 17]}}
{"token": ["The", "Hsp70", "chaperone", "increases", "CHIP-mediated", "ubiquitination", "of", "C4019083#ent", "<e1>", "in", "vitro", "and", "the", "tetratricopeptide", "repeat", "domain", "which", "mediates", "C0057856#ent", "<e2>", "interactions", "with", "chaperones", ",", "is", "required", "for", "C4019083#ent", "<e1>", "ubitiquination", "in", "cell", "culture"], "h": {"id": "C0057856", "name": "C0057856#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4019083", "name": "C4019083#ent", "pos": [7, 8]}}
{"token": ["Cold", "exposure", "a", "significant", "increase", "in", "pulmonary", "arterial", "pressure", "C0031681#ent", "<e1>", ")", ",", "pulmonary", "arterial", "wedge", "pressure", "Ppaw", ")", ",", "and", "pulmonary", "vascular", "resistance", "C0242852#ent", "<e2>", ")", "at", "both", "1,524", "and", "3,048", "m", "without", "affecting", "cardiac", "output"], "h": {"id": "C0031681", "name": "C0031681#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242852", "name": "C0242852#ent", "pos": [24, 25]}}
{"token": ["Infusion", "of", "captopril", "(", "10", "micrograms/kg/min", ")", "in", "normoxia", "revealed", "a", "tendency", "to", "increase", "the", "mean", "pulmonary", "arterial", "pressure", "C0031681#ent", "<e1>", ")", "and", "the", "pulmonary", "vascular", "resistance", "C0242852#ent", "<e2>", ")", "following", "the", "systemic", "vasodilation"], "h": {"id": "C0031681", "name": "C0031681#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0242852", "name": "C0242852#ent", "pos": [27, 28]}}
{"token": ["These", "changes", "were", "characterized", "by", "decreased", "BP", ",", "elevated", "C0031681#ent", "<e1>", ",", "and", "elevated", "C0242852#ent", "<e2>", ",", "associated", "with", "decreases", "in", "PaO2", ",", "cardiac", "output", "mixed", "venous", "oxygen", "tension"], "h": {"id": "C0031681", "name": "C0031681#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242852", "name": "C0242852#ent", "pos": [14, 15]}}
{"token": ["Our", "data", "suggest", "that", "C0050066#ent", "<e1>", "protects", "rats", "from", "C2697656#ent", "<e2>", "by", "blocking", "LPS-induced", "NF-kappaB", "activation", "leading", "to", "inhibition", "of", "NO", "and", "TNF-alpha", "overproduction", "and", "thereby", "reversing", "the", "LPS-induced", "vascular", "hyporeactivity", "."], "h": {"id": "C0050066", "name": "C0050066#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}}
{"token": ["The", "amounts", "of", "C1166521#ent", "<e1>", ",", "copper", ",", "TIBC", ",", "and", "C1420113#ent", "<e2>", "were", "measured", "in", "serum", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420113", "name": "C1420113#ent", "pos": [11, 12]}}
{"token": ["Damage", "to", "the", "kidney", "was", "severe", ",", "leading", "to", "a", "C1704321#ent", "<e1>", "resulting", "in", "ascites", ",", "pleural", "effusion", "hypercholesterolaemia", "and", "C0020557#ent", "<e2>", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [20, 21]}}
{"token": ["A", "prominent", "C1704321#ent", "<e1>", "hypercholesterolemia", "and", "C0020557#ent", "<e2>", "was", "present", "and", "led", "to", "extensive", "lipid", "infiltration", "the", "aortic", "intima"], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [6, 7]}}
{"token": ["C0055891#ent", "<e1>", "has", "minimal", "C0358430#ent", "<e2>", "hypnotic", "activity", "."], "h": {"id": "C0055891", "name": "C0055891#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0358430", "name": "C0358430#ent", "pos": [4, 5]}}
{"token": ["ActRIIB", ",", "and", "then", "partners", "with", "a", "type", "I", "receptor", "either", "C1332011#ent", "<e1>", "ALK4", "or", "ActRIB", ")", "or", "ALK5", "(", "C1420610#ent", "<e2>", ")", ",", "to", "induce", "phosphorylation", "of", "Smad2/Smad3", "and", "activate", "a", "TGF-beta-like", "signaling", "pathway"], "h": {"id": "C1332011", "name": "C1332011#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [20, 21]}}
{"token": ["ActRIIB", ",", "and", "then", "partners", "with", "a", "type", "I", "receptor", "either", "activin", "receptor-like", "kinase", "4", "C1332011#ent", "<e1>", "or", "ActRIB", ")", "or", "ALK5", "(", "C1420610#ent", "<e2>", ")", ",", "to", "induce", "phosphorylation", "of", "Smad2/Smad3", "and", "activate", "a", "TGF-beta-like", "signaling", "pathway"], "h": {"id": "C1332011", "name": "C1332011#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [23, 24]}}
{"token": ["All", "24", "men", "with", "acute", "gonococcal", "urethritis", "and", "seven", "of", "the", "men", "with", "symptomless", "C0018078#ent", "<e1>", "had", "yielded", "C0018081#ent", "<e2>", "midstream", "urine", "samples", "were", "examined", "by", "suprapubic", "puncture", "before", "morning", "voiding", "."], "h": {"id": "C0018078", "name": "C0018078#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [18, 19]}}
{"token": ["Diacylglycerols", "were", "found", "to", "inhibit", "DMSO-induced", "differentiation", "dose", "responsively", "with", "the", "order", "of", "potency", "being", "1-oleoyl-2-acetylglycerol", "(", "OAG", ")", "greater", "than", "C0054616#ent", "<e1>", "greater", "than", "dilaurin", "greater", "than", "C0058323#ent", "<e2>", "."], "h": {"id": "C0054616", "name": "C0054616#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0058323", "name": "C0058323#ent", "pos": [28, 29]}}
{"token": ["We", "have", "identified", "dominant", "mutations", "that", "suppress", "the", "lethality", "associated", "with", "R217", "-", "->L", "mutation", "in", "the", "GTP.Ras", "binding", "region", "(", "C1413694#ent", "<e1>", ")", "of", "the", "Drosophila", "raf", "D-raf", ")", "C1414387#ent", "<e2>"], "h": {"id": "C1413694", "name": "C1413694#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [30, 31]}}
{"token": ["Authors", "suggested", "it", "is", "necessary", "to", "carry", "out", "full", "differential", "diagnosis", "considering", "C0859976#ent", "<e1>", "patients", "with", "unsatisfactory", "treatment", "of", "recurrent", "C0035204#ent", "<e2>"], "h": {"id": "C0859976", "name": "C0859976#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [20, 21]}}
{"token": ["The", "alpha", "precursor", "region", ",", "from", "C0002523#ent", "<e1>", "to", "carboxyl", "terminus", "pro", ",", "C1418385#ent", "<e2>", ",", "and", "disintegrin", "domains"], "h": {"id": "C0002523", "name": "C0002523#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418385", "name": "C1418385#ent", "pos": [13, 14]}}
{"token": ["The", "results", "indicated", "that", "C0879590#ent", "<e1>", "induced", "an", "increase", "in", "the", "amounts", "of", "immunoreactive", "C1332830#ent", "<e2>", "its", "mRNA", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332830", "name": "C1332830#ent", "pos": [14, 15]}}
{"token": ["Small", "injections", "C3889156#ent", "<e1>", "were", "made", "into", "these", "structures", "from", "the", "C3273239#ent", "<e2>", "surface", "after", "they", "had", "been", "visualized", "directly", "by", "dissection", "of", "the", "overlying", "bone", "."], "h": {"id": "C3889156", "name": "C3889156#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273239", "name": "C3273239#ent", "pos": [11, 12]}}
{"token": ["To", "characterize", "this", "innervation", ",", "horseradish", "peroxidase", "C3889156#ent", "<e1>", ")", "and", "C3889156#ent", "<e1>", "conjugated", "to", "wheat", "germ", "agglutinin", "applied", "to", "the", "C3273239#ent", "<e1>", "and", "dural", "arteries", "sinuses", "of", "33", "cats", "."], "h": {"id": "C3889156", "name": "C3889156#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273239", "name": "C3273239#ent", "pos": [21, 22]}}
{"token": ["No", "C0027947#ent", "<e1>", "was", "seen", "after", "the", "C0025677#ent", "<e2>", "infusions", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [7, 8]}}
{"token": ["To", "review", "experience", "with", "C0027947#ent", "<e1>", "related", "to", "low-dose", "C0025677#ent", "<e2>", "patients", "with", "psoriasis", "and", "rheumatoid", "arthritis"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [9, 10]}}
{"token": ["Mutations", "in", "C3273615#ent", "<e1>", "are", "responsible", "for", "C0272170#ent", "<e2>", "SDS", ")", ",", "a", "disorder", "with", "clinical", "features", "of", "exocrine", "pancreatic", "insufficiency", "bone", "marrow", "failure", "and", "skeletal", "abnormalities"], "h": {"id": "C3273615", "name": "C3273615#ent", "pos": [2, 3]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "the", "C0002876#ent", "<e1>", "can", "handle", "C0001056#ent", "<e2>", "(GlcNAc)2", "-", "7", "."], "h": {"id": "C0002876", "name": "C0002876#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001056", "name": "C0001056#ent", "pos": [7, 8]}}
{"token": ["Intriguingly", ",", "C1423716#ent", "<e1>", "-", "1", "is", "part", "of", "a", "gene", "cluster", "five", "highly", "C1334043#ent", "<e2>", "and", "similarly", "regulated", "genes", "designated", "mig2", "-", "1", "to", "C1423716#ent", "<e1>", "-", "5", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1423716", "name": "C1423716#ent", "pos": [2, 3]}}
{"token": ["The", "survey", "of", "the", "available", "literature", "revealed", "two", "cases", "of", "alternariosis", "and", "C0010481#ent", "<e1>", "but", "in", "these", "two", "cases", "the", "diagnosis", "of", "the", "C0014130#ent", "<e2>", "was", "already", "established", "when", "the", "cutaneous", "infection", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [23, 24]}}
{"token": ["Immunization", "against", "C3495919#ent", "<e1>", "Arp", ")", "elicits", "antibody", "in", "mice", "that", "resolves", "C0029408#ent", "<e2>", "but", "is", "not", "protective", "against", "challenge", "with", "Borrelia", "burgdorferi"], "h": {"id": "C3495919", "name": "C3495919#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [12, 13]}}
{"token": ["In", "the", "therapeutic", "experiment", "collagen-induced", "arthritis", "CIA", ")", ",", "C3495919#ent", "<e1>", "TCRs", "were", "isolated", "from", "single", "T", "cells", "in", "the", "C0029408#ent", "<e2>"], "h": {"id": "C3495919", "name": "C3495919#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [20, 21]}}
{"token": ["Accordingly", ",", "BA-induced", "invasion", "was", "associated", "with", "activation", "of", "the", "Rac1", "and", "C0018296#ent", "<e1>", "expression", "of", "the", "C1417825#ent", "<e2>"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417825", "name": "C1417825#ent", "pos": [17, 18]}}
{"token": ["The", "Kawahara", "'s", "paper", "on", "this", "C0338451#ent", "<e1>", "known", "as", "\"", "C1839259#ent", "<e2>", "or", "\"", "Kennedy-Alter-Sung", "disease", "\"", "is", "the", "first", "description", "in", "the", "world", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [11, 12]}}
{"token": ["The", "6", "other", "patients", "had", "clinically", "isolated", "C3665349#ent", "<e1>", "secondary", "to", "TSH", "deficiency", "eventually", "associated", "to", "clinically", "inapparent", "GH", "or", "ACTH", "C0268487#ent", "<e2>", ",", "most", "of", "them", "by", "hypothalamic", "defect", "normal", "response", "TRH", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [21, 22]}}
{"token": ["The", "target", "of", "the", "FKBP12-rapamycin", "complex", "is", "C0076836#ent", "<e1>", ",", "a", "lipid", "and", "C1512488#ent", "<e2>", "is", "likely", "to", "be", "required", "for", "T-cell", "proliferation", "response", "to", "interleukin-2", "."], "h": {"id": "C0076836", "name": "C0076836#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [13, 14]}}
{"token": ["Collectively", ",", "these", "observations", "suggest", "a", "potential", "sex-dependent", "link", "between", "abnormalities", "in", "C1416426#ent", "<e1>", "expression", "and", "C3653518#ent", "<e2>", "the", "pathophysiology", "of", "BD", "."], "h": {"id": "C1416426", "name": "C1416426#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3653518", "name": "C3653518#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "the", "avirulent", "V42", "exerted", "no", "C0054757#ent", "<e1>", "in", "IFN-treated", "cells", "and", "production", "of", "C0042769#ent", "<e2>", "four", "orders", "of", "magnitude", "lower", "compared", "with", "untreated", "cells", "."], "h": {"id": "C0054757", "name": "C0054757#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [16, 17]}}
{"token": ["Following", "C4283784#ent", "<e1>", "treatment", ",", "p21", "associated", "with", "inhibited", "C0694873#ent", "<e2>", "and", "CDK2", ",", "and", "this", "correlated", "with", "reduced", "phosphorylation", "of", "retinoblastoma", "proteins"], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0694873", "name": "C0694873#ent", "pos": [9, 10]}}
{"token": ["The", "hSOD1-induced", "decline", "in", "C1420120#ent", "<e1>", "[3H]d-aspartate", "uptake", "not", "blocked", "by", "the", "antioxidant", "Trolox", "potentiated", "by", "antioxidant", "depletion", "C0007367#ent", "<e2>", "and", "glutathione", "peroxidase", "inhibitors"], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [18, 19]}}
{"token": ["It", "is", "known", "that", "matrixmetalloproteinase-1", "(", "C2001899#ent", "<e1>", ")", "canonically", "activates", "the", "thrombin", "receptor", "C1366449#ent", "<e2>", ")", "and", "we", "recently", "reported", "that", "highly", "metastatic", "tumor", "cells", "melanoma", "and", "colon", "cancer", "secreting", "matrixmetalloproteinase-1", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366449", "name": "C1366449#ent", "pos": [14, 15]}}
{"token": ["We", "recently", "determined", "that", "stromal-derived", "C2001899#ent", "<e1>", "also", "acts", "as", "a", "signaling", "molecule", "cleaving", "protease-activated", "receptor", "1", "C1366449#ent", "<e2>", ")", "to", "cause", "breast", "cancer", "cell", "migration", "invasion", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366449", "name": "C1366449#ent", "pos": [17, 18]}}
{"token": ["The", "data", "provide", "the", "first", "evidence", "for", "C3540641#ent", "<e1>", "being", "one", "candidate", "C0017337#ent", "<e2>", "encoding", "the", "Drosophila", "DNA", "methyltransferase(s", ")", "."], "h": {"id": "C3540641", "name": "C3540641#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["Therefore", "the", "severity", "of", "the", "dm", "null", "phenotype", "likely", "due", "to", "unopposed", "repression", "by", "C3540641#ent", "<e1>", "on", "a", "subset", "of", "C0017337#ent", "<e2>", "critical", "for", "cell", "and", "organismal", "growth"], "h": {"id": "C3540641", "name": "C3540641#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["To", "elucidate", "the", "expression", "profiles", "C3540641#ent", "<e1>", "in", "Artemia", "franciscana", "we", "isolated", "the", "C0017337#ent", "<e2>", "encoding", "a", "C3540641#ent", "<e1>", "from", "A.", "franciscana", "and", "named", "it", "as", "AfDnmt2", "."], "h": {"id": "C3540641", "name": "C3540641#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["Although", "the", "anti-inflammatory", "effect", "interleukin-1", "(", "IL-1", ")", "receptor", "antagonist", "(", "C1504688#ent", "<e1>", ")", "has", "been", "described", ",", "the", "contribution", "of", "this", "C1333196#ent", "<e2>", "to", "cholesterol", "metabolism", "unclear", "."], "h": {"id": "C1504688", "name": "C1504688#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [22, 23]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "ability", "of", "human", "recombinant", "C1504688#ent", "<e1>", "IL-1ra", ")", "to", "inhibit", "IL-1-induced", "C1333196#ent", "<e2>", "production", "in", "human", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "and", "isolated", "monocytes", "."], "h": {"id": "C1504688", "name": "C1504688#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [18, 19]}}
{"token": ["Recent", "data", "implicate", "C0012890#ent", "<e1>", "UV-induced", "repair", "synthesis", "and", "suggest", "that", "C0012892#ent", "<e2>", "delta", "are", "both", "involved", "in", "semiconservative", "replication", "."], "h": {"id": "C0012890", "name": "C0012890#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [11, 12]}}
{"token": ["Clinical", "revaluation", "genetic", "analysis", "six", "Indian", "pedigrees", ",", "segregating", "autosomal", "dominant", "cerebellar", "ataxia", "slow", "saccades", "and", "C0031117#ent", "<e1>", "has", "been", "undertaken", ",", "and", "expansion", "at", "the", "C0752121#ent", "<e2>", "SCA2", ")", "locus", "was", "confirmed", "in", "14", "affected", "family", "members"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [26, 27]}}
{"token": ["Slow", "saccades", ",", "postural/intention", "tremor", "C0031117#ent", "<e1>", "and", "decreased", "deep-tendon", "reflexes", "valuable", "neurological", "signs", "clinical", "suspicion", "of", "C0752121#ent", "<e2>", "SCA2", ")", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [17, 18]}}
{"token": ["Slow", "saccades", "C0031117#ent", "<e1>", "not", "seen", "consistently", "in", "our", "ethnic", "Bengalee", "subjects", "with", "C0752121#ent", "<e2>", "genotype", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [13, 14]}}
{"token": ["A", "previously", "healthy", "47-year-old", "woman", "presented", "reporting", "nausea", ",", "anorexia", "and", "C0220870#ent", "<e1>", "of", "2", "weeks", "'", "C2926735#ent", "<e2>", ",", "and", "three", "episodes", "of", "syncope", "."], "h": {"id": "C0220870", "name": "C0220870#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [17, 18]}}
{"token": ["C1539026#ent", "<e1>", "formed", "a", "protein", "complex", "C0290178#ent", "<e2>", "was", "phosphorylated", "in", "vitro"], "h": {"id": "C1539026", "name": "C1539026#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0290178", "name": "C0290178#ent", "pos": [6, 7]}}
{"token": ["Syndromic", "MCDs", "with", "CNS", "involvement", "include", "mitochondrial", "encephalomyopathy", "lactacidosis", ",", "stroke-like", "episodes", "syndrome", ",", "myoclonic", "epilepsy", "ragged", "red", "fibers", "syndrome", "mitochondrial", "neuro-gastrointestinal", "encephalomyopathy", "syndrome", "C0151786#ent", "<e1>", "ataxia", ",", "and", "retinitis", "pigmentosa", "syndrome", "mitochondrial", "depletion", "syndrome", "C0022541#ent", "<e2>", "and", "Leigh", "syndrome", "Leber's", "hereditary", "optic", "neuropathy", "Friedreich's", "ataxia", "and", "multiple", "systemic", "lipomatosis"], "h": {"id": "C0151786", "name": "C0151786#ent", "pos": [24, 25]}, "relation": "manifestation_of", "t": {"id": "C0022541", "name": "C0022541#ent", "pos": [35, 36]}}
{"token": ["The", "protein", "component", "Alzheimer's", "disease", "amyloid", "neurofibrillary", "tangles", "amyloid", "plaque", "cores", "and", "C0085220#ent", "<e1>", "is", "an", "aggregated", "C1305923#ent", "<e2>", "with", "a", "subunit", "mass", "approximately", "4", "kDa", "(", "the", "A4", "monomer", "."], "h": {"id": "C0085220", "name": "C0085220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [17, 18]}}
{"token": ["These", "data", "show", "that", "the", "transcriptional", "regulation", "the", "C1706005#ent", "<e1>", "complex", "and", "that", "C1166521#ent", "<e2>", "may", "play", "a", "key", "role", "in", "TRAP", "gene", "regulation"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [13, 14]}}
{"token": ["By", "pulsed-field", "gel", "electrophoresis", "Southern", "analysis", "HTS1", "sequences", "chromosome-specific", "markers", ",", "the", "C1705582#ent", "<e1>", "detected", "on", "a", "4-Mb", "chromosome", "one", "group", "of", "C1875400#ent", "<e2>", "and", "on", "a", "2.3-Mb", "chromosome", "in", "another", "group", ",", "which", "lacked", "the", "4-Mb", "chromosome"], "h": {"id": "C1705582", "name": "C1705582#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [22, 23]}}
{"token": ["In", "C0011849#ent", "<e1>", ",", "the", "expression", "and", "function", "of", "ryanodine", "receptor", "RyR", ")", "C1413043#ent", "<e2>", "+", "release", "channels", "are", "reduced", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [13, 14]}}
{"token": ["Elevated", "serum", "aminotransferase", "decreased", "more", "rapidly", "during", "the", "treatment", "of", "C0241911#ent", "<e1>", "of", "chronic", "hepatitis", "B.", "Variations", "in", "C0002484#ent", "<e2>", "not", "observed", "in", "any", "of", "the", "untreated", "C0241911#ent", "<e1>", "patients", "."], "h": {"id": "C0002484", "name": "C0002484#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0241911", "name": "C0241911#ent", "pos": [10, 11]}}
{"token": ["Sedating", "AEDs", "may", "benefit", "C0014544#ent", "<e1>", "patients", "with", "C1950154#ent", "<e2>", ",", "and", "stimulating", "AEDs", "may", "benefit", "C0014544#ent", "<e1>", "patients", "with", "daytime", "sleepiness"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [8, 9]}}
{"token": ["Neurochemical", "and", "behavioural", "research", "show", "that", "benzodiazepines", "(", "BZs", ")", "are", "the", "well-known", "anxiolytic", "drugs", "are", "also", "used", "for", "the", "treatment", "of", "C0014544#ent", "<e1>", ",", "hypnosis", "and", "C1950154#ent", "<e2>", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [27, 28]}}
{"token": ["GPA", "expresses", "M", "or", "N", "blood", "group", "antigen", "on", "the", "allelic", "gene", "C1539593#ent", "<e1>", "GPAN", "gene", ")", ",", "while", "C1415374#ent", "<e2>", "expresses", "only", "the", "N", "antigen"], "h": {"id": "C1539593", "name": "C1539593#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415374", "name": "C1415374#ent", "pos": [19, 20]}}
{"token": ["We", "have", "determined", "the", "substrate", "specificity", "of", "a", "mouse", "aldo-keto", "reductase", "AKR", ")", "AKR7A5", ",", "an", "enzyme", "that", "is", "similar", "to", "rat", "aflatoxin", "aldehyde", "reductase", "C1332073#ent", "<e1>", ")", "and", "to", "human", "C0219300#ent", "<e2>", "AKR7A2", ")", "."], "h": {"id": "C1332073", "name": "C1332073#ent", "pos": [25, 26]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0219300", "name": "C0219300#ent", "pos": [31, 32]}}
{"token": ["We", "have", "determined", "the", "substrate", "specificity", "of", "a", "mouse", "aldo-keto", "reductase", "AKR", ")", "AKR7A5", ",", "an", "enzyme", "that", "is", "similar", "to", "rat", "C1332073#ent", "<e1>", "AKR7A1", ")", "and", "to", "human", "brain", "succinic", "semialdehyde", "reductase", "C0219300#ent", "<e2>", ")", "."], "h": {"id": "C1332073", "name": "C1332073#ent", "pos": [22, 23]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0219300", "name": "C0219300#ent", "pos": [33, 34]}}
{"token": ["This", "provides", "conclusive", "evidence", "that", "C1332073#ent", "<e1>", "is", "the", "major", "C0219300#ent", "<e2>", "these", "cells", "."], "h": {"id": "C1332073", "name": "C1332073#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0219300", "name": "C0219300#ent", "pos": [10, 11]}}
{"token": ["Determination", "of", "the", "apparent", "Km", "reveals", "that", "C1332073#ent", "<e1>", "has", "highest", "affinity", "for", "9,10-phenanthrenequinone", "and", "C0219300#ent", "<e2>", "and", "low", "affinity", "for", "glyoxal", "and", "DL-glyceraldehyde", "."], "h": {"id": "C1332073", "name": "C1332073#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0219300", "name": "C0219300#ent", "pos": [15, 16]}}
{"token": ["It", "is", "largely", "used", "in", "horses", ",", "in", "the", "form", "of", "C0025179#ent", "<e1>", "for", "the", "treatment", "of", "C1290884#ent", "<e2>", "colics", ",", "and", "often", "identified", "in", "dopage", "cases", "."], "h": {"id": "C0025179", "name": "C0025179#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [17, 18]}}
{"token": ["The", "C4284459#ent", "<e1>", "mutant", "of", "S.", "cerevisiae", "a", "novel", "phenotype", ":", "meiotic", "chromosomes", "nearly", "C2987364#ent", "<e2>", "amounts", "of", "synaptonemal", "complex", "but", "most", "chromosomes", "are", "engaged", "in", "synapsis", "with", "nonhomologous", "partners", "."], "h": {"id": "C4284459", "name": "C4284459#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [14, 15]}}
{"token": ["Defects", "in", "C1412402#ent", "<e1>", "underlie", "many", "C0852077#ent", "<e2>", "the", "mislocalization", "of", "membrane", "proteins"], "h": {"id": "C1412402", "name": "C1412402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0852077", "name": "C0852077#ent", "pos": [6, 7]}}
{"token": ["Cdc45", ",", "C0108855#ent", "<e1>", ",", "Cyclin", "A", "and", "phospho-H1", "associate", "with", "chromatin", "during", "S-phase", ",", "and", "Cdc45", ",", "C0108855#ent", "<e1>", ",", "and", "an", "active", "C0599716#ent", "<e1>", "interact", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0599716", "name": "C0599716#ent", "pos": [24, 25]}}
{"token": ["Patients", "with", "acute", "uncomplicated", "C0042029#ent", "<e1>", "and", "chronic", "complicated", "C0042029#ent", "<e1>", "were", "enrolled", "and", "C0065162#ent", "<e1>", "dosages", "of", "200", "mg", "b.i.d", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0065162", "name": "C0065162#ent", "pos": [14, 15]}}
{"token": ["In", "patients", "greater", "than", "or", "equal", "to", "65", "years", "of", "age", "with", "uncomplicated", "C0042029#ent", "<e1>", "the", "bacterial", "eradication", "rate", "for", "C0065162#ent", "<e2>", "was", "100", "%", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0065162", "name": "C0065162#ent", "pos": [20, 21]}}
{"token": ["C0004135#ent", "<e1>", "is", "a", "multisystem", "recessive", "disease", "characterized", "clinically", "by", "cerebellar", "ataxia", "C0039446#ent", "<e2>", "immunodeficiency", ",", "sensitivity", "to", "radiomimetic", "agents", "and", "an", "increased", "predisposition", "to", "cancer", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0039446", "name": "C0039446#ent", "pos": [12, 13]}}
{"token": ["Severe", "C0040961#ent", "<e1>", "most", "often", "results", "from", "left-sided", "heart", "disease", "C0155616#ent", "<e2>"], "h": {"id": "C0040961", "name": "C0040961#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0155616", "name": "C0155616#ent", "pos": [10, 11]}}
{"token": ["The", "case", "in", "discussion", "is", "that", "of", "a", "38-year-old", "patient", "with", "a", "history", "of", "C0003862#ent", "<e1>", ",", "anemia", "and", "a", "C0039082#ent", "<e2>"], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [20, 21]}}
{"token": ["C0030424#ent", "<e1>", "one", "of", "the", "most", "important", "endemic", "C0747256#ent", "<e2>", "Korea", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [8, 9]}}
{"token": ["C0030424#ent", "<e1>", "is", "a", "benign", "C0747256#ent", "<e2>", "by", "Paragonimus", "westermani", "endemic", "in", "Japan", ",", "mostly", "in", "south-western", "area", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [5, 6]}}
{"token": ["A", "700-kb", "region", "of", "DNA", "in", "human", "chromosome", "16p13.3", "been", "shown", "to", "contain", "the", "polycystic", "kidney", "disease", "1", "C2987024#ent", "<e1>", ")", "and", "the", "C0694895#ent", "<e2>", "TSC2", ")", "disease", "genes"], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0694895", "name": "C0694895#ent", "pos": [23, 24]}}
{"token": ["The", "patients", "'", "postoperative", "course", "was", "essentially", "uneventful", "until", "the", "7th", "day", "when", "he", "developed", "fever", ",", "persistent", "hiccup", ",", "C0042571#ent", "<e1>", "followed", "by", "obtundation", "and", "C0476273#ent", "<e2>"], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [26, 27]}}
{"token": ["Using", "the", "yeast", "two-hybrid", "system", "we", "screened", "for", "C0086376#ent", "<e1>", "interacting", "with", "presenilin", "2", "PS2", ")", "and", "cloned", "C1708021#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1708021", "name": "C1708021#ent", "pos": [18, 19]}}
{"token": ["Several", "such", "C0991617#ent", "<e1>", "are", "cleared", "by", "biliary", "excretion", "significantly", "reduce", "C3812692#ent", "<e2>", "T2", "of", "liver", "and", "bile", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3812692", "name": "C3812692#ent", "pos": [11, 12]}}
{"token": ["SERT", "activity", "is", "completely", "lost", "when", "the", "midline", "is", "separated", "but", "is", "then", "rescued", "by", "bath-applied", "C0919506#ent", "<e1>", "(", "fibroblast", "growth", "factor", "2", ",", "which", "can", "activate", "the", "C1333542#ent", "<e2>"], "h": {"id": "C0919506", "name": "C0919506#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333542", "name": "C1333542#ent", "pos": [28, 29]}}
{"token": ["Streptavidin", "induced", "C0919506#ent", "<e1>", "dimers", "bind", "and", "activate", "C1333542#ent", "<e2>", "in", "the", "presence", "of", "heparin", "."], "h": {"id": "C0919506", "name": "C0919506#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333542", "name": "C1333542#ent", "pos": [8, 9]}}
{"token": ["Heparan", "sulfate", "HS", ")", "regulates", "the", "kinetics", "of", "C0919506#ent", "<e1>", "intracellular", "signaling", "and", "differentially", "activates", "cell", "proliferation", "cells", "expressing", "different", "C1333542#ent", "<e2>", "FGFRs", ")", "."], "h": {"id": "C0919506", "name": "C0919506#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333542", "name": "C1333542#ent", "pos": [20, 21]}}
{"token": ["Here", ",", "we", "provide", "evidence", "that", "G", "protein-coupled", "receptor", "kinase", "1", "C1384522#ent", "<e1>", ")", ",", "which", "is", "most", "similar", "to", "the", "beta-adrenergic", "receptor", "kinases", "C1384522#ent", "<e1>", "GRK2", ")", "and", "GRK3", ",", "is", "the", "fly", "RK", "."], "h": {"id": "C1384522", "name": "C1384522#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1384522", "name": "C1384522#ent", "pos": [11, 12]}}
{"token": ["The", "translocation", "of", "these", "proteins", "to", "the", "endoplasmic", "reticulum", "C1420408#ent", "<e1>", "depletion", "suggests", "that", "an", "alternative", "pathway", "C1823521#ent", "<e2>", "in", "trypanosomes", "."], "h": {"id": "C1420408", "name": "C1420408#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [17, 18]}}
{"token": ["While", "overexpression", "of", "C3540812#ent", "<e1>", "rescued", "the", "pkc1", "-", "371", "temperature-sensitive", "cell", "lysis", "phenotype", ",", "disruption", "of", "C3540812#ent", "<e1>", "lowered", "the", "restrictive", "temperature", "of", "the", "pkc1", "-", "371", "C0002085#ent", "<e1>", "."], "h": {"id": "C3540812", "name": "C3540812#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [28, 29]}}
{"token": ["These", "studies", "were", "undertaken", "to", "determine", "how", "C1334349#ent", "<e1>", "LOX", ")", "and", "C0024375#ent", "<e2>", "LOXL", ")", "enzymes", "are", "targeted", "to", "their", "substrates", "in", "the", "extracellular", "matrix"], "h": {"id": "C1334349", "name": "C1334349#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0024375", "name": "C0024375#ent", "pos": [12, 13]}}
{"token": ["C0055461#ent", "<e1>", ",", "thioridazine", ",", "befunolol", ",", "C0031937#ent", "<e2>", ",", "daunomycin", "and", "5-fluorouracil", "bound", "to", "melanin", "at", "pH", "7.0", "and", "4.8", "."], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031937", "name": "C0031937#ent", "pos": [7, 8]}}
{"token": ["The", "authors", "findings", "showed", "that", "C0055461#ent", "<e1>", ",", "thioridazine", ",", "befunolol", ",", "C0031937#ent", "<e2>", ",", "daunomycin", ",", "and", "5-fluorouracil", "bound", "to", "melanin", "(", "pH", "4.8", ",", "7.4", ",", "and", "8.0", ")", "."], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031937", "name": "C0031937#ent", "pos": [12, 13]}}
{"token": ["C1567710#ent", "<e1>", "mediates", "acute", "neuronal", "cell", "death", "induced", "by", "a", "variety", "of", "insults", "including", "C0007785#ent", "<e2>", "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced", "Parkinsonism", ",", "and", "CNS", "trauma"], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [14, 15]}}
{"token": ["Dilations", "to", "C1514550#ent", "<e1>", "(", "but", "not", "independent", ")", "vasodilators", "were", "attenuated", "after", "C3273436#ent", "<e2>", "."], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [13, 14]}}
{"token": ["Neither", "inhibition", "nor", "activation", "of", "C1514550#ent", "<e1>", "IL-8", "production", "in", "the", "absence", "or", "presence", "of", "C3273436#ent", "<e2>", "."], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [15, 16]}}
{"token": ["In", "particular", ",", "experiments", "on", "submitochondrial", "particles", "that", "the", "competitive", "inhibition", "concerned", "the", "following", "enzymes", ":", "NADH", "dehydrogenase", "C1453024#ent", "<e1>", "reduced", "ubiquinone", ":", "C0311584#ent", "<e2>"], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0311584", "name": "C0311584#ent", "pos": [23, 24]}}
{"token": ["The", "C1453024#ent", "<e1>", "NADH", "dehydrogenase", "and", "III", "(", "C0311584#ent", "<e2>", "form", "a", "stable", "core", "respirasome", "to", "which", "complex", "IV", "cytochrome", "c", "oxidase", "can", "also", "bind", "."], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0311584", "name": "C0311584#ent", "pos": [8, 9]}}
{"token": ["The", "specific", "activity", "of", "C1453024#ent", "<e1>", "antimycin", "A", "sensitive", "NADH", "C0311584#ent", "<e2>", "and", "the", "myocardial", "concentrations", "of", "coenzyme", "Q10", "CoQ10", ")", "increased", "significantly", "(", "P", "<", "0.05", ")", "with", "increasing", "aortic", "valve", "pressure", "."], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0311584", "name": "C0311584#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "the", "response", "of", "serum", "interleukin-1", "(", "IL-1", ")", "and", "C1332791#ent", "<e1>", "GM-CSF", ")", "to", "infection", "of", "C0162429#ent", "<e2>", "patients", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [18, 19]}}
{"token": ["A", "series", "of", "achiral", "and", "chiral", "compounds", "chromatographed", "on", "the", "phases", "including", "benzodiazepinones", ",", "C0003211#ent", "<e1>", "amino", "acids", "warfarin", "and", "C2721771#ent", "<e2>", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2721771", "name": "C2721771#ent", "pos": [20, 21]}}
{"token": ["Biopsies", "were", "taken", "10", "cm", "above", "the", "lateral", "malleolus", "and", "5-mum", "sections", "were", "stained", "with", "hematoxylin", "and", "C0885297#ent", "<e1>", "and", "the", "panaxonal", "marker", "protein", "gene", "product", "C1418520#ent", "<e2>", ")", "9.5", "."], "h": {"id": "C0885297", "name": "C0885297#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418520", "name": "C1418520#ent", "pos": [26, 27]}}
{"token": ["C0027849#ent", "<e1>", "NMS", ")", "develops", "during", "the", "use", "of", "C0040615#ent", "<e2>", ",", "whereas", "serotonin", "syndrome", "caused", "mainly", "by", "serotoninergic", "antidepressants"], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [9, 10]}}
{"token": ["C0027849#ent", "<e1>", "a", "rare", "but", "serious", "adverse", "effect", "C0040615#ent", "<e2>"], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "in", "inner", "medulla", "COX-2", "but", "not", "C1565830#ent", "<e1>", "is", "upregulated", "by", "C0268009#ent", "<e2>", "."], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268009", "name": "C0268009#ent", "pos": [14, 15]}}
{"token": ["Previous", "studies", "have", "demonstrated", "that", "growth", "hormone", "C3539616#ent", "<e1>", ")", "has", "a", "marked", "anabolic", "effect", "cortical", "bone", "parathyroid", "hormone", "C1705340#ent", "<e2>", ")", "has", "been", "shown", "to", "increase", "cancellous", "bone", "cortical", "bone", "in", "ovariectomized", "(", "OVX", ")", "rats", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [19, 20]}}
{"token": ["In", "proliferative", "chondrocytes", ",", "growth", "hormone", "C3539616#ent", "<e1>", ")", "and", "the", "calciotropic", "hormones", "parathyroid", "hormone", "C1705340#ent", "<e2>", ")", "and", "1,25-dihydroxyvitamin", "D", "1alpha,25(OH)2D3", "]", "increase", "cell", "proliferation", "stimulation", "of", "paracrine", "insulin-like", "growth", "factor-I", "IGF-I", ")", "secretion", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [15, 16]}}
{"token": ["There", "is", "much", "controversy", "about", "the", "treatment", "of", "Lyme", "disease", "respect", "to", "2", "poorly", "defined", "entities", ":", "\"", "C3890422#ent", "<e1>", "and", "\"", "posttreatment", "C0024198#ent", "<e2>"], "h": {"id": "C3890422", "name": "C3890422#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0024198", "name": "C0024198#ent", "pos": [23, 24]}}
{"token": ["Taken", "together", ",", "these", "results", "demonstrate", "that", "C1418858#ent", "<e1>", "is", "directly", "involved", "in", "C0376515#ent", "<e2>", "dephosphorylation", "during", "mitotic", "slippage", "."], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", ",", "we", "characterized", "C1418858#ent", "<e1>", "as", "the", "cytosolic", "phosphatase", "in", "C0376515#ent", "<e2>", "dephosphorylation", "."], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [14, 15]}}
{"token": ["Inhibitors", "of", "guanylate", "cyclase", "of", "C3489929#ent", "<e1>", "G-kinase", ")", "inhibited", "stimulation", "of", "migration", "by", "C1622105#ent", "<e2>", ",", "suggesting", "that", "cGMP", "played", "a", "decisive", "role", "in", "the", "stimulatory", "effect", "of", "C1622105#ent", "<e2>", "."], "h": {"id": "C3489929", "name": "C3489929#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [14, 15]}}
{"token": ["Recent", "studies", "in", "C0949990#ent", "<e1>", "implicated", "several", "new", "extracellular", "molecules", "such", "as", "C1334880#ent", "<e2>", "and", "heparan", "sulfate", "proteoglycans", "in", "axonal", "tract", "formation", "at", "the", "midline", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334880", "name": "C1334880#ent", "pos": [12, 13]}}
{"token": ["This", "study", "provides", "further", "evidence", "for", "the", "aetiological", "role", "of", "pityrosporon", "yeasts", "in", "C0036508#ent", "<e1>", "of", "the", "efficacy", "of", "topical", "C0022625#ent", "<e2>", "in", "its", "treatment", "."], "h": {"id": "C0036508", "name": "C0036508#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [20, 21]}}
{"token": ["These", "data", "suggest", "that", "once-daily", "ketoconazole", "gel", "%", "is", "an", "effective", "treatment", "for", "C0036508#ent", "<e1>", "a", "viable", "alternative", "to", "the", "C0022625#ent", "<e2>", "%", "formulation", "."], "h": {"id": "C0036508", "name": "C0036508#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [20, 21]}}
{"token": ["The", "purpose", "of", "our", "study", "was", "to", "determine", "if", "insulin", "administration", "before", "significantly", "C2712370#ent", "<e1>", "neurologic", "deficit", "survival", "after", "ischemia", "using", "a", "newly", "developed", "rat", "C0007785#ent", "<e2>", "model", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [25, 26]}}
{"token": ["This", "experiment", "was", "designed", "to", "determine", "if", "nitrous", "oxide", "C2712370#ent", "<e1>", "neurologic", "and", "pathologic", "outcome", "temporary", "C0007785#ent", "<e2>", "spontaneously", "hypertensive", "rats", "deeply", "anesthetized", "with", "a", "barbiturate", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [16, 17]}}
{"token": ["We", "here", "report", "a", "case", "of", "C0796126#ent", "<e1>", "atypically", "as", "a", "sub-acute", "C0270612#ent", "<e2>", "following", "satisfactory", "psychomotor", "development", "to", "the", "age", "of", "16", "months", "."], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0270612", "name": "C0270612#ent", "pos": [12, 13]}}
{"token": ["The", "gene", "product", "hydrolyzed", "C0007068#ent", "<e1>", "showed", "strong", "cross", "reactivity", "P.", "funiculosum", "C1260229#ent", "<e2>", "."], "h": {"id": "C0007068", "name": "C0007068#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1260229", "name": "C1260229#ent", "pos": [12, 13]}}
{"token": ["In", "particular", ",", "we", "report", "that", "SMYD2", "interacted", "with", "HSP90alpha", "independently", "of", "the", "SET", "and", "MYND", "domains", ",", "with", "EBP41L3", "through", "the", "C1520223#ent", "<e1>", "and", "with", "C1705526#ent", "<e2>", "through", "the", "SET", "domain"], "h": {"id": "C1520223", "name": "C1520223#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [26, 27]}}
{"token": ["To", "investigate", "this", "problem", "we", "exposed", "cultured", "human", "leukemic", "T-lymphoblasts", "to", "1-hr", "pulse", "doses", "an", "alkylating", "agent", "C0065506#ent", "<e1>", ")", "and", "a", "C0598317#ent", "<e2>", "etoposide", ")", "that", "cause", "delayed", "cell", "death"], "h": {"id": "C0065506", "name": "C0065506#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0598317", "name": "C0598317#ent", "pos": [22, 23]}}
{"token": ["The", "initial", "C0521471#ent", "<e1>", "on", "day", "+", "32", "simulated", "C0011974#ent", "<e2>", "which", "progressed", "to", "a", "belt-shaped", "rash", "and", "then", "developed", "hyperkeratotic", "nodules", "the", "hands", "."], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011974", "name": "C0011974#ent", "pos": [9, 10]}}
{"token": ["C0031008#ent", "<e1>", "provided", "a", "good", "treatment", "for", "the", "C0039082#ent", "<e2>", "particularly", "for", "the", "more", "severe", "RL", "cases", "without", "significant", "problems", "with", "RL", "augmentation", "."], "h": {"id": "C0031008", "name": "C0031008#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}}
{"token": ["We", "compared", "latanoprost", "monotherapy", "therapy", "timolol/", "C0165590#ent", "<e1>", "in", "patients", "with", "C0017612#ent", "<e2>", "evaluate", "the", "effects", "on", "intraocular", "pressure", "IOP", ")", "and", "occurrence", "of", "adverse", "events"], "h": {"id": "C0165590", "name": "C0165590#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [11, 12]}}
{"token": ["To", "describe", "the", "response", "of", "a", "child", "with", "persistent", "fungemia", "to", "C0537894#ent", "<e1>", ",", "a", "member", "of", "the", "echinocandin", "class", "C0003308#ent", "<e2>", "."], "h": {"id": "C0537894", "name": "C0537894#ent", "pos": [11, 12]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [20, 21]}}
{"token": ["This", "study", "suggests", "that", "the", "C1447799#ent", "<e1>", "-", "0", "genotype", "might", "have", "an", "interaction", "with", "C0577631#ent", "<e2>", "to", "RA", "in", "Korean", "postmenopausal", "RA", "women", "without", "histories", "of", "smoking", "."], "h": {"id": "C1447799", "name": "C1447799#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0577631", "name": "C0577631#ent", "pos": [15, 16]}}
{"token": ["However", ",", "patients", "treated", "with", "C0751039#ent", "<e1>", "are", "at", "a", "risk", "for", "C0035078#ent", "<e2>", "may", "be", "more", "susceptible", "to", "colon", "cancer"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "1", "x", "10(-7", ")", "M", "C1366535#ent", "<e1>", "significantly", "activated", "C0170168#ent", "<e2>", "14.0", "to", "24.5", "pmol/mg", "protein", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "whether", "the", "severity", "of", "symptoms", "associated", "with", "C0242994#ent", "<e1>", "related", "to", "the", "serotype", "of", "the", "C0042769#ent", "<e2>"], "h": {"id": "C0242994", "name": "C0242994#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [23, 24]}}
{"token": ["Hantavirus", "pulmonary", "syndrome", "C0242994#ent", "<e1>", ")", "is", "a", "rodentborne", "C0042769#ent", "<e2>", "by", "severe", "pulmonary", "illness", "and", "a", "case-fatality", "ratio", "of", "30%-40", "%", "."], "h": {"id": "C0242994", "name": "C0242994#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}}
{"token": ["We", "performed", "fast", "fluid-attenuated", "inversion", "recovery", "fFLAIR", ")", "and", "conventional", "spin", "echo", "C1822723#ent", "<e1>", ")", "brain", "MRI", "in", "32", "C0026769#ent", "<e2>", "MS", ")", "patients", "(", "eight", "each", "benign", ",", "relapsing-remitting", ",", "primary", "progressive", "and", "secondary", "progressive", "."], "h": {"id": "C1822723", "name": "C1822723#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [19, 20]}}
{"token": ["We", "performed", "fast", "fluid-attenuated", "inversion", "recovery", "fFLAIR", ")", "and", "conventional", "spin", "echo", "C1822723#ent", "<e1>", ")", "brain", "MRI", "in", "32", "multiple", "sclerosis", "C0026769#ent", "<e2>", ")", "patients", "(", "eight", "each", "benign", ",", "relapsing-remitting", ",", "primary", "progressive", "and", "secondary", "progressive", "."], "h": {"id": "C1822723", "name": "C1822723#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [21, 22]}}
{"token": ["Ten", "to", "15", "min", "prior", "to", "each", "C0032143#ent", "<e1>", "application", ",", "one", "group", "received", "topical", "CsA", "in", "C0001002#ent", "<e2>", "(", "1", "mg/mouse", ")", ",", "and", "the", "other", "C0001002#ent", "<e2>", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [17, 18]}}
{"token": ["The", "promotion", "was", "performed", "by", "twice", "weekly", "applications", "of", "12-O-tetradecanoyl", "phorbol-13-acetate", "C0032143#ent", "<e1>", ")", "(", "3", "or", "5", "micrograms/animal", "in", "100", "microliters", "C0001002#ent", "<e2>", ")", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [22, 23]}}
{"token": ["C1419206#ent", "<e1>", "immunoreactivity", "(", "-IR", ")", "was", "always", "colocalized", "with", "C1420554#ent", "<e2>", "and", "synapsin", "I-IR", "in", "nerve", "terminals", "the", "spinal", "cord", "peripheral", "nerve", "endings", "."], "h": {"id": "C1419206", "name": "C1419206#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420554", "name": "C1420554#ent", "pos": [10, 11]}}
{"token": ["Immunoblotting", "data", "demonstrated", "that", "C1419206#ent", "<e1>", ",", "synaptotagmin", ",", "cellubrevin", ",", "synaptobrevin", "2", "syntaxin", "1", "SNAP-25", "and", "C1420554#ent", "<e2>", "were", "well", "represented", "in", "anterior", "pituitary", "cells", "well", "as", "in", "the", "corticotroph", "cell", "line", "AtT-20"], "h": {"id": "C1419206", "name": "C1419206#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420554", "name": "C1420554#ent", "pos": [17, 18]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "if", "2", "functional", "C0907532#ent", "<e1>", "eNOS", ")", "gene", "polymorphisms", "be", "risk", "factors", "C0149931#ent", "<e2>", "."], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [20, 21]}}
{"token": ["Also", ",", "amount", "and", "distribution", "of", "cornified", "envelope", "proteins", "involucrin", "loricrin", ",", "filaggrin", ",", "and", "of", "the", "keratins", "K1", "C3810570#ent", "<e1>", "were", "significantly", "altered", "in", "C0007428#ent", "<e2>", "D-deficient", "mice", "."], "h": {"id": "C3810570", "name": "C3810570#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [25, 26]}}
{"token": ["C0017887#ent", "<e1>", ",", "hydralazine", ",", "and", "C0028005#ent", "<e2>", "produced", "concentration-dependent", "relaxation", "of", "U46619-preconstricted", "HUA", "segments", "from", "normotensive", "and", "PIH", "patients", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [6, 7]}}
{"token": ["In", "this", "study", "we", "examined", "perioperative", "blood", "losses", "maxillo-facial", "surgery", "2", "techniques", "for", "controlled", "hypotension", "C0017887#ent", "<e1>", "(", "NTG", ")", "and", "C0028005#ent", "<e2>", "(", "NICAR", ")", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [21, 22]}}
{"token": ["Pyrilamine", ",", "a", "typical", "antihistamine", "agent", "showed", "little", "difference", "among", "these", "doses", "and", "antiallergic", "drugs", "antihistamine", "activity", "i.e.", ",", "terfenadine", ",", "azelastine", "and", "C0022642#ent", "<e1>", ",", "had", "effects", "between", "TMK688", "and", "C0034282#ent", "<e2>", "."], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0034282", "name": "C0034282#ent", "pos": [31, 32]}}
{"token": ["The", "occurrence", "and", "type", "of", "C0234133#ent", "<e1>", "investigated", "in", "143", "patients", "with", "dementia", "of", "the", "C1843013#ent", "<e2>"], "h": {"id": "C0234133", "name": "C0234133#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C1843013", "name": "C1843013#ent", "pos": [15, 16]}}
{"token": ["C3536709#ent", "<e1>", "and", "plasma", "therapy", "little", "effect", "to", "his", "C0427055#ent", "<e2>", "."], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [9, 10]}}
{"token": ["In", "the", "presence", "of", "C0084061#ent", "<e1>", ",", "anti", "tPA", "IgG", "was", "more", "effective", "than", "anti", "C0042071#ent", "<e2>", "IgG", "in", "suppressing", "argatroban-induced", "thrombolysis", "."], "h": {"id": "C0084061", "name": "C0084061#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [15, 16]}}
{"token": ["Our", "results", "rule", "out", "hydrolase", "II", "a", "carnosinase", ",", "non-serine", "esterase", ",", "plasminogen", "activator", "C0162745#ent", "<e1>", "or", "collagenase", "activator", "suggest", "that", "it", "is", "a", "C1413809#ent", "<e2>"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413809", "name": "C1413809#ent", "pos": [24, 25]}}
{"token": ["In", "cirrhosis", "and", "the", "C1704321#ent", "<e1>", "the", "specific", "C3536833#ent", "<e2>", "spironolactone", ",", "alone", "or", "in", "combination", "with", "other", "diuretics", ",", "has", "proven", "to", "be", "highly", "efficacious", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536833", "name": "C3536833#ent", "pos": [8, 9]}}
{"token": ["Cases", "of", "BBS", "mapping", "ro", "BBS6", "are", "caused", "by", "mutations", "in", "C0948368#ent", "<e1>", ";", "mutations", "in", "this", "gene", "also", "cause", "McKusick-Kaufman", "syndrome", "C0269209#ent", "<e2>", ",", "post-axial", "polydactyly", "congenital", "heart", "defects", "."], "h": {"id": "C0948368", "name": "C0948368#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0269209", "name": "C0269209#ent", "pos": [22, 23]}}
{"token": ["C0948368#ent", "<e1>", "an", "autosomal", "recessive", "multiple", "malformation", "syndrome", "characterized", "by", "C0269209#ent", "<e2>", "and", "polydactyly", "."], "h": {"id": "C0948368", "name": "C0948368#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0269209", "name": "C0269209#ent", "pos": [10, 11]}}
{"token": ["C0948368#ent", "<e1>", "MKKS", ",", "MIM", "236700", ")", "is", "a", "human", "developmental", "anomaly", "syndrome", "C0269209#ent", "<e2>", "(", "HMC", ")", ",", "postaxial", "polydactyly", "PAP", ")", "and", "congenital", "heart", "disease", "CHD", ")", "."], "h": {"id": "C0948368", "name": "C0948368#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0269209", "name": "C0269209#ent", "pos": [13, 14]}}
{"token": ["Among", "these", ",", "the", "expression", "of", "C1420045#ent", "<e1>", "was", "markedly", "downregulated", "in", "C1415491#ent", "<e2>", ",", "and", "inactivation", "of", "C1420045#ent", "<e1>", "expression", "was", "associated", "with", "LOH", "at", "16q12.1", "."], "h": {"id": "C1420045", "name": "C1420045#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415491", "name": "C1415491#ent", "pos": [12, 13]}}
{"token": ["We", "have", "previously", "shown", "that", "expression", "of", "C1420045#ent", "<e1>", "is", "frequently", "down-regulated", "in", "C1415491#ent", "<e2>", "and", "associated", "with", "advanced", "stages"], "h": {"id": "C1420045", "name": "C1420045#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415491", "name": "C1415491#ent", "pos": [13, 14]}}
{"token": ["Subsequently", ",", "we", "evaluated", "the", "relation", "between", "C1420045#ent", "<e1>", "expression", ",", "confirmed", "by", "semiquantitative", "RT-PCR", "and", "clinicopathological", "parameters", "in", "C1415491#ent", "<e2>", "."], "h": {"id": "C1420045", "name": "C1420045#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415491", "name": "C1415491#ent", "pos": [19, 20]}}
{"token": ["The", "activity", "of", "this", "C1706513#ent", "<e1>", "is", "not", "altered", "by", "DNAse", "or", "C0035541#ent", "<e2>", "but", "is", "destroyed", "by", "heating", "or", "trypsin", "."], "h": {"id": "C1706513", "name": "C1706513#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [12, 13]}}
{"token": ["A", "C0878682#ent", "<e1>", "results", "in", "massive", "accumulations", "of", "iron", "in", "the", "C0023899#ent", "<e2>", "and", "brain", "and", "is", "associated", "with", "retinal", "degeneration", "diabetes", "."], "h": {"id": "C0878682", "name": "C0878682#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}}
{"token": ["The", "present", "investigation", "was", "designed", "to", "examine", "the", "influence", "of", "C0020445#ent", "<e1>", "the", "metabolism", "of", "lipids", "in", "response", "to", "C2936882#ent", "<e2>", "exposure", "."], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [19, 20]}}
{"token": ["The", "antidepressants", "most", "frequently", "prescribed", "were", "C0002600#ent", "<e1>", ",", "clomipramine", ",", "trazodone", "and", "C0023961#ent", "<e2>", "."], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023961", "name": "C0023961#ent", "pos": [13, 14]}}
{"token": ["Concentrations", "of", "C1705783#ent", "<e1>", "in", "CSF", "in", "the", "patients", "of", "C0042373#ent", "<e2>", "measured", "by", "radioimmunoassay", "."], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [10, 11]}}
{"token": ["Calcitonin", "gene-related", "peptide", "C1705783#ent", "<e1>", ")", "is", "a", "vasoactive", "neuropeptide", "biological", "activity", "potential", "therapeutic", "value", "many", "C0042373#ent", "<e2>"], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [16, 17]}}
{"token": ["Studies", "were", "performed", "to", "explore", "the", "effect", "of", "C2936886#ent", "<e1>", "antagonism", "with", "C0015772#ent", "<e2>", "for", "8", "weeks", "on", "glucose", "homeostasis", "serum", "lipids", "8", "patients", "with", "essential", "hypertension"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [12, 13]}}
{"token": ["The", "findings", "indicate", "that", "C2936886#ent", "<e1>", "antagonism", "with", "C0015772#ent", "<e2>", "does", "not", "affect", "glucose-induced", "insulin", "release", "in", "vivo"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "short-term", "C2936886#ent", "<e1>", "antagonism", "with", "C0015772#ent", "<e2>", "on", "blood", "pressure", "on", "plasma", "catecholamines", "renin", ",", "and", "aldosterone", "was", "studied", "in", "10", "normal", "volunteers", "rest", "and", "during", "incremental", "bicycle", "exercise"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [8, 9]}}
{"token": ["Broadly", ",", "the", "C1414120#ent", "<e1>", "defective", "in", "these", "C0026848#ent", "<e2>", "be", "classified", "into", "categories", "based", "on", "their", "intracellular", "locations", "."], "h": {"id": "C1414120", "name": "C1414120#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [8, 9]}}
{"token": ["These", "observations", "underline", "the", "importance", "of", "considering", "both", "genetic", "variability", "enzyme", "C0597298#ent", "<e1>", "as", "well", "as", "enzyme", "level", "C1418754#ent", "<e2>", "status", ")", "and", "the", "developmental", "time", "course", "appearance", "of", "C1418754#ent", "<e2>", "in", "developing", "risk", "assessment", "models", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418754", "name": "C1418754#ent", "pos": [18, 19]}}
{"token": ["KT5823", "(", "a", "C0243459#ent", "<e1>", "antagonized", "effects", "of", "trans-ACPD", ",", "8-bromo-cGMP", ",", "and", "C0037533#ent", "<e2>"], "h": {"id": "C0243459", "name": "C0243459#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [13, 14]}}
{"token": ["Behavioral", "effects", "of", "C0014892#ent", "<e1>", "(", "MS-4101", ")", ",", "a", "new", "derivative", "of", "C0005064#ent", "<e2>", ",", "was", "investigated", "and", "compared", "with", "effects", "of", "diazepam", "in", "mice", "and", "rats", "."], "h": {"id": "C0014892", "name": "C0014892#ent", "pos": [3, 4]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [13, 14]}}
{"token": ["Incubation", "of", "the", "cells", "with", "C1415033#ent", "<e1>", "not", "only", "increased", "C1706002#ent", "<e2>", "and", "ChAT", "gene", "expression", "p75-", "cells", ",", "but", "also", "augmented", "the", "expression", "of", "these", "genes", "in", "p75", "+", "cells", "."], "h": {"id": "C1415033", "name": "C1415033#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706002", "name": "C1706002#ent", "pos": [10, 11]}}
{"token": ["C0215825#ent", "<e1>", "may", "play", "a", "role", "in", "the", "pathophysiology", "of", "C0011884#ent", "<e2>"], "h": {"id": "C0215825", "name": "C0215825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [10, 11]}}
{"token": ["Rheumatoid", "neutrophilic", "dermatitis", "C0814154#ent", "<e1>", ")", "is", "an", "uncommon", ",", "but", "distinctive", "manifestation", "of", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0814154", "name": "C0814154#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [14, 15]}}
{"token": ["Although", "C0020538#ent", "<e1>", "pregnancy", "are", "more", "likely", "to", "occur", "in", "C3828492#ent", "<e2>", "the", "question", "of", "whether", "they", "occur", "more", "frequently", "in", "gestational", "diabetics", "certain", "subsets", "of", "gestational", "diabetics", "unclear", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3828492", "name": "C3828492#ent", "pos": [10, 11]}}
{"token": ["Strains", "were", "constructed", "lacking", "C4284184#ent", "<e1>", "(", "a", "previously", "characterized", "C1537985#ent", "<e2>", ",", "Cox2", ",", "or", "both", ",", "which", "all", "grew", "diazotrophically", "."], "h": {"id": "C4284184", "name": "C4284184#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [10, 11]}}
{"token": ["One", "of", "these", "proteins", ",", "Pet100p", ",", "is", "a", "novel", "molecular", "chaperone", "functions", "to", "incorporate", "a", "subcomplex", "containing", "C4284184#ent", "<e1>", "VIIa", "and", "VIII", "into", "C1537985#ent", "<e2>", "."], "h": {"id": "C4284184", "name": "C4284184#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [24, 25]}}
{"token": ["Cotransfection", "analyses", "confirmed", "that", "both", "STAT5-binding", "sites", "were", "necessary", "for", "the", "700-bp", "DNA", "region", "to", "mediate", "C1335875#ent", "<e1>", "or", "STAT5b", "activation", "of", "C0812327#ent", "<e2>"], "h": {"id": "C1335875", "name": "C1335875#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [22, 23]}}
{"token": ["Both", "1100delC", "and", "R145W", "germ-line", "mutations", "C1706047#ent", "<e1>", "are", "associated", "with", "loss", "of", "the", "wild-type", "C1706112#ent", "<e2>", "in", "the", "corresponding", "tumor", "specimens", "and", "neither", "tumor", "harbors", "a", "somatic", "TP53", "mutation", "."], "h": {"id": "C1706047", "name": "C1706047#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [15, 16]}}
{"token": ["C0003886#ent", "<e1>", "AMC", ")", "is", "a", "heterogeneous", "group", "C1854664#ent", "<e2>", "some", "of", "which", "are", "hereditary", "."], "h": {"id": "C0003886", "name": "C0003886#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C1854664", "name": "C1854664#ent", "pos": [8, 9]}}
{"token": ["This", "article", "reviews", "the", "rapidly", "expanding", "applications", "of", "beta-amino", "acids", "in", "the", "design", "of", "bioactive", "peptide", "analogues", "ranging", "from", "C0162757#ent", "<e1>", "antagonists", ",", "MHC-binding", "peptides", ",", "antimicrobial", "peptides", "C0033607#ent", "<e2>"], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [28, 29]}}
{"token": ["The", "authors", "investigated", "the", "incidence", "of", "arterial", "hypertension", "C0156221#ent", "<e1>", "adults", "and", "during", "the", "period", "after", "C0017658#ent", "<e2>", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [16, 17]}}
{"token": ["Urinary", "fibrin-degradation", "products", "a", "well-known", "marker", "of", "C0156221#ent", "<e1>", "viral", "antigens", "have", "induced", "an", "C0017658#ent", "<e2>", "the", "8", "controls", "in", "whom", "an", "influenza-like", "disease", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [14, 15]}}
{"token": ["In", "the", "under-60s", ",", "ulcers", "were", "healed", "in", "a", "greater", "proportion", "of", "patients", "given", "C0008783#ent", "<e1>", "than", "in", "those", "given", "C0006979#ent", "<e2>", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006979", "name": "C0006979#ent", "pos": [20, 21]}}
{"token": ["We", "studied", "C1419254#ent", "<e1>", "expression", "during", "HL-60", "differentiation", "induced", "by", "VD", "and", "C0243192#ent", "<e2>"], "h": {"id": "C1419254", "name": "C1419254#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}}
{"token": ["Sequence", "analysis", "nine", "potential", "sites", "for", "C2931005#ent", "<e1>", "the", "H", "proteins", "the", "new", "C1875400#ent", "<e2>", ",", "in", "contrast", "to", "four", "in", "the", "H", "protein", "the", "Onderstepoort", "strain", "."], "h": {"id": "C2931005", "name": "C2931005#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [13, 14]}}
{"token": ["Metachromatic", "leukodystrophy", "C3539689#ent", "<e1>", ")", "presents", "as", "six", "separate", "variant", "forms", ",", "four", "C0002085#ent", "<e2>", "and", "two", "non-allelic", "."], "h": {"id": "C3539689", "name": "C3539689#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [13, 14]}}
{"token": ["A", "hereditary", "dysmyelination", "mutation", ",", "named", "myelin", "deficient", "C3539689#ent", "<e1>", ")", ",", "is", "considered", "to", "be", "C0002085#ent", "<e2>", "to", "shiverer", ",", "a", "deletion", "mutation", "of", "the", "myelin", "basic", "protein", "MBP", ")", "gene", "."], "h": {"id": "C3539689", "name": "C3539689#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [16, 17]}}
{"token": ["Accurate", "diagnosis", "of", "C3539689#ent", "<e1>", "is", "complicated", "by", "the", "presence", "of", "so-called", "pseudodeficiency", "C0002085#ent", "<e2>", "and", "the", "need", "to", "receive", "specimens", "for", "biochemical", "testing", "24", "-", "48", "h", "of", "collection", "."], "h": {"id": "C3539689", "name": "C3539689#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [13, 14]}}
{"token": ["Multiple", "copies", "human", "C1705982#ent", "<e1>", "large", "amounts", "of", "K-ras", "mRNAs", "and", "C0086376#ent", "<e2>", "were", "found", "in", "the", "transformed", "cells"], "h": {"id": "C1705982", "name": "C1705982#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Multiple", "copies", "human", "K-ras", "genes", "large", "amounts", "of", "C1705982#ent", "<e1>", "mRNAs", "and", "C0086376#ent", "<e2>", "were", "found", "in", "the", "transformed", "cells"], "h": {"id": "C1705982", "name": "C1705982#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["DRG", "B", "patients", "(21%)--those", "who", "had", "sustained", "VT", "or", "C0042510#ent", "<e1>", "induced", ",", "but", "did", "not", "require", "C0002598#ent", "<e2>", "and", "had", "no", "serious", "concurrent", "illnesses", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0002598", "name": "C0002598#ent", "pos": [17, 18]}}
{"token": ["Forty-one", "patients", "(", "71", "%", ")", "had", "no", "recurrence", "of", "symptomatic", "VT", "or", "C0042510#ent", "<e1>", "while", "being", "treated", "with", "C0002598#ent", "<e2>", "(", "mean", "follow-up", "period", ",", "17.1", "+", "/-", "12.4", "months", ")", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0002598", "name": "C0002598#ent", "pos": [19, 20]}}
{"token": ["On", "the", "contrary", ",", "uPAR-bound", "complexes", "of", "C1335224#ent", "<e1>", "with", "its", "C0003015#ent", "<e2>", "PAI-1", "(", "plasminogen", "activator", "inhibitor", "type-1", "or", "PN-1", "(", "protease", "nexin-1", "are", "readily", "internalized", "in", "several", "cell", "types"], "h": {"id": "C1335224", "name": "C1335224#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [11, 12]}}
{"token": ["This", "IL-1alpha-augmented", "C2001899#ent", "<e1>", "secretion", "was", "partially", "but", "significantly", "blocked", "by", "an", "NO", "synthase", "inhibitor", "C0068821#ent", "<e2>"], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0068821", "name": "C0068821#ent", "pos": [15, 16]}}
{"token": ["He", "complained", "of", "a", "C0723402#ent", "<e1>", "foul", "odor", "the", "mouth", ",", "progressive", "dyspnea", ",", "and", "C0034362#ent", "<e2>", "months", "after", "the", "completion", "of", "radiotherapy", "."], "h": {"id": "C0723402", "name": "C0723402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034362", "name": "C0034362#ent", "pos": [15, 16]}}
{"token": ["After", "C0040822#ent", "<e1>", "with", "ascorbic", "acid", "ethanol", ",", "the", "C3714649#ent", "<e2>", "are", "extracted", "from", "the", "serum", "samples", "with", "petroleum", "ether"], "h": {"id": "C0040822", "name": "C0040822#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [9, 10]}}
{"token": ["C0025183#ent", "<e1>", "choreiform", "movements", "of", "C0030196#ent", "<e2>", "occur", "with", "moderate", "frequency", "among", "psychiatric", "patients"], "h": {"id": "C0025183", "name": "C0025183#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [5, 6]}}
{"token": ["We", "also", "then", "examined", "the", "effects", "of", "C0022265#ent", "<e1>", "the", "expression", "of", "17", "C3538859#ent", "<e2>", "cell", "lines", "from", "endometrial", "carcinoma", "Northern", "blotting", "analysis", "examine", "the", "possible", "roles", "of", "retinoids", "in", "in", "situ", "endometrial", "estrogen", "metabolism", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3538859", "name": "C3538859#ent", "pos": [13, 14]}}
{"token": ["A", "patient", "with", "C0005283#ent", "<e1>", "is", "described", "who", "developed", "a", "lower", "motor", "neurone", "C0015469#ent", "<e2>", "the", "left", "side", "together", "with", "a", "phrenic", "nerve", "palsy", "the", "same", "side", ",", "during", "the", "course", "of", "the", "illness", "."], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015469", "name": "C0015469#ent", "pos": [13, 14]}}
{"token": ["In", "this", "article", ",", "we", "shall", "be", "discussing", "clinical", "types", "C0004238#ent", "<e1>", ",", "etiology", ",", "the", "mechanism", "of", "C4255166#ent", "<e2>", ",", "symptoms", ",", "complications", "and", "approach", "to", "treatment", "in", "various", "clinical", "scenarios", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4255166", "name": "C4255166#ent", "pos": [18, 19]}}
{"token": ["The", "average", "twenty-four-hour", "systolic", "diastolic", "BPs", "C1705296#ent", "<e1>", "and", "DBP", ")", "were", "lowered", "by", "C1569495#ent", "<e2>", "treatment", "and", "returned", "to", "the", "pretreatment", "levels", "within", "two", "days", "of", "C1569495#ent", "<e2>", "withdrawal", "."], "h": {"id": "C1705296", "name": "C1705296#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1569495", "name": "C1569495#ent", "pos": [14, 15]}}
{"token": ["In", "the", "ELISAs", ",", "13", "out", "of", "18", "C0024141#ent", "<e1>", "sera", "reacted", "with", "the", "target", "C1870006#ent", "<e2>", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [15, 16]}}
{"token": ["C0034494#ent", "<e1>", ",", "an", "acute", "progressive", "encephalitis", ",", "is", "an", "ancient", "C0043528#ent", "<e2>", "."], "h": {"id": "C0034494", "name": "C0034494#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [11, 12]}}
{"token": ["The", "C0079429#ent", "<e1>", "(", "PFP", "alpha", ")", "encoding", "C3273601#ent", "<e2>", "alpha", "is", "approx", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273601", "name": "C3273601#ent", "pos": [8, 9]}}
{"token": ["The", "C0079429#ent", "<e1>", "has", "two", "promoters", "(", "C3273601#ent", "<e2>", "and", "P2", ")", "upstream", "of", "two", "alternative", "first", "exons", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273601", "name": "C3273601#ent", "pos": [7, 8]}}
{"token": ["The", "complete", "C0079429#ent", "<e1>", "encoding", "the", "structural", "protein", "FMDV", "(", "C3273601#ent", "<e2>", ")", "was", "subcloned", "into", "expression", "vector", ",", "resulting", "in", "the", "fusion", "expression", "plasmid", "pKG-P1", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273601", "name": "C3273601#ent", "pos": [10, 11]}}
{"token": ["Five", "patients", "had", "later", "a", "rheumatoid", "arthritis", "one", "had", "a", "C0035435#ent", "<e1>", "one", "a", "C0151436#ent", "<e2>", "one", "had", "a", "sero-negative", "spondylarthropathy"], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151436", "name": "C0151436#ent", "pos": [14, 15]}}
{"token": ["Pylorus", "biopsies", "13", "C1867403#ent", "<e1>", "patients", "were", "examined", "for", "C0132555#ent", "<e2>", "isoform", "expression", "."], "h": {"id": "C1867403", "name": "C1867403#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [9, 10]}}
{"token": ["We", "have", "compared", "the", "anticholinergic", "and", "a", "dopamine", "mimetic", "C0003405#ent", "<e1>", "their", "effects", "on", "serum", "neuroleptic", "activity", "C2984121#ent", "<e2>", ")", "and", "serum", "anticholinergic", "activity", "SAA", ")", "."], "h": {"id": "C0003405", "name": "C0003405#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2984121", "name": "C2984121#ent", "pos": [17, 18]}}
{"token": ["C0017658#ent", "<e1>", "an", "entity", "first", "thought", "to", "have", "represented", "a", "C0277554#ent", "<e2>", "uncertain", "histogenesis", ",", "but", "more", "recently", "has", "generally", "been", "considered", "to", "represent", "a", "morphologic", "variant", "of", "membranoproliferative", "glomerulonephritis"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0277554", "name": "C0277554#ent", "pos": [10, 11]}}
{"token": ["We", "have", "identified", "a", "series", "of", "either", "highly", "conserved", "or", "invariant", "residues", "that", "are", "found", "in", "all", "family", "4", "C3541394#ent", "<e1>", "as", "well", "as", "other", "retaining", "C0085249#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [26, 27]}}
{"token": ["Polymerization", "of", "chitin", "requires", "the", "presence", "of", "active", "chitin", "synthases", "CHS", ")", ",", "a", "group", "of", "C3541394#ent", "<e1>", "belonging", "to", "the", "family", "of", "C0085249#ent", "<e2>"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [23, 24]}}
{"token": ["This", "C0039082#ent", "<e1>", "may", "be", "associated", "with", "specific", "diseases", "(", "e.g.", "C0009782#ent", "<e2>", "or", "with", "malignancies", ",", "but", "it", "may", "also", "appear", "in", "isolated", "form", "(", "primary", "APS", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [11, 12]}}
{"token": ["This", "observation", "indicates", "that", "arachidonic", "acid", "metabolites", "are", "important", "in", "the", "alveolar", "bone", "loss", "C0031099#ent", "<e1>", "and", "suggests", "a", "use", "for", "C0016377#ent", "<e2>", "in", "the", "management", "of", "bone", "resorption", "disease", "."], "h": {"id": "C0031099", "name": "C0031099#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0016377", "name": "C0016377#ent", "pos": [21, 22]}}
{"token": ["The", "juxtamembrane", "sequence", "of", "c-Kit", "contains", "recruitment", "sites", "the", "Src", "family", "kinases", "Fyn", "and", "C1442804#ent", "<e1>", ",", "as", "well", "as", "Shp1", "and", "C1706044#ent", "<e2>", "protein-tyrosine", "phosphatases"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [22, 23]}}
{"token": ["Considering", "that", "C1442804#ent", "<e1>", "and", "Fyn", "are", "major", "Src-family", "PTKs", "expressed", "in", "BAF-B03", "cells", ",", "our", "data", "suggest", "that", "C1442804#ent", "<e1>", "may", "be", "principally", "responsible", "for", "the", "tyrosine", "phosphorylation", "C1706044#ent", "<e1>", "in", "F7", "cells"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [29, 30]}}
{"token": ["A", "major", "C0597336#ent", "<e1>", "QTL", ")", "controlling", "response", "to", "photoperiod", ",", "C1333891#ent", "<e2>", ",", "was", "identified", "by", "means", "of", "a", "map-based", "cloning", "strategy", "."], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [11, 12]}}
{"token": ["C0038525#ent", "<e1>", "induce", "increases", "of", "NF-kappaB", "C0812382#ent", "<e2>", "the", "gene", "expression", "of", "TNF-alpha", ",", "interleukin", "(IL)-1", "beta", "ICAM-1", ",", "and", "vascular", "cell", "adhesion", "molecule", ",", "which", "were", "reduced", "in", "the", "PDTC", "group", "."], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [6, 7]}}
{"token": ["C0009088#ent", "<e1>", "such", "as", "trigeminal", "neuralgia", "C0032768#ent", "<e2>", "manifest", "herpes", "zoster", "affecting", "the", "face", ",", "become", "markedly", "more", "frequent", "with", "age", "."], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032768", "name": "C0032768#ent", "pos": [6, 7]}}
{"token": ["To", "assess", "the", "potential", "of", "a", "superhigh-potency", "0.1", "%", "C0016299#ent", "<e1>", "suppress", "the", "hypothalamic-pituitary-adrenal", "(HPA)", "in", "pediatric", "patients", "with", "C0011615#ent", "<e2>"], "h": {"id": "C0016299", "name": "C0016299#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [19, 20]}}
{"token": ["Only", "PCB", "126", "was", "found", "to", "upregulate", "cyclin", "A", "C1538717#ent", "<e1>", ",", "and", "to", "increase", "both", "total", "C0108855#ent", "<e2>", "cdk2", ")", "and", "cyclin", "A/cdk2", "complex", "activities", "."], "h": {"id": "C1538717", "name": "C1538717#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0108855", "name": "C0108855#ent", "pos": [17, 18]}}
{"token": ["The", "normal", "increase", "in", "the", "concentration", "of", "serum", "thyroid", "stimulating", "hormone", "after", "the", "administration", "of", "protirelin", "(", "C0699184#ent", "<e1>", ")", "suggested", "that", "the", "primary", "abnormality", "in", "the", "C0020655#ent", "<e2>", "the", "release", "of", "the", "pituitary", "hormones"], "h": {"id": "C0699184", "name": "C0699184#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020655", "name": "C0020655#ent", "pos": [27, 28]}}
{"token": ["Overexpression", "of", "C1335224#ent", "<e1>", "or", "deficiency", "of", "PAI-1", "promotes", "neointima", "and", "C0751003#ent", "<e2>", "formation", ",", "which", "is", "probably", "due", "to", "active", "remodelling", "extracellular", "matrix", "vascular", "wall", "by", "excess", "plasmin", "."], "h": {"id": "C1335224", "name": "C1335224#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [11, 12]}}
{"token": ["Mutations", "within", "known", "C1417679#ent", "<e1>", "account", "for", "a", "small", "proportion", "of", "cases", "of", "C1415935#ent", "<e2>", "and", "CPHD", ",", "suggesting", "the", "role", "of", "other", "as", "yet", "unidentified", "genetic", "and", "environmental", "factors"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415935", "name": "C1415935#ent", "pos": [13, 14]}}
{"token": ["UK", "studies", "have", "shown", "that", "early", "supported", "discharge", "(", "C1414459#ent", "<e1>", ")", "for", "patients", "with", "exacerbations", "of", "C1647218#ent", "<e2>", "can", "reduce", "the", "length", "of", "stay", "adversely", "affecting", "mortality", "or", "readmission", "rates"], "h": {"id": "C1414459", "name": "C1414459#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [17, 18]}}
{"token": ["The", "mutant", "protein", "unable", "to", "promote", "initiation", "of", "plasmid", "replication", "in", "vivo", "42", "degrees", "C.", "Both", "the", "wild-type", "and", "the", "C0678941#ent", "<e1>", "cloned", "separately", "into", "the", "high-expression", "vector", "C1706169#ent", "<e2>"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1706169", "name": "C1706169#ent", "pos": [28, 29]}}
{"token": ["Among", "the", "genes", "we", "cloned", "is", "MOT1", ",", "encoding", "a", "repressor", "that", "inhibits", "C1705304#ent", "<e1>", "binding", "to", "the", "promoter", ",", "thus", "linking", "glucose", "repression", "C1705304#ent", "<e1>", "access", "to", "C0008546#ent", "<e1>", "."], "h": {"id": "C1705304", "name": "C1705304#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [28, 29]}}
{"token": ["Activation", "of", "C0033634#ent", "<e1>", "decreases", "normal", "and", "neoplastic", "cell", "proliferation", "inhibiting", "C1414313#ent", "<e2>", "signaling", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "receptor", "internalization", "morphine", "was", "facilitated", "by", "inhibition", "of", "C0033634#ent", "<e1>", "opioid-mediated", "transactivation", "of", "C1414313#ent", "<e2>", "EGFR", ")", ",", "both", "activating", "ERK/MAP", "kinases", "by", "opioids", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "methodical", "problems", "in", "determination", "of", "trace", "elements", "misinterpretations", "of", "study", "results", "lead", "to", "unjustified", "assignment", "from", "several", "C0029896#ent", "<e1>", "in", "the", "group", "of", "C0235950#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0235950", "name": "C0235950#ent", "pos": [25, 26]}}
{"token": ["Estimation", "of", "C1416681#ent", "<e1>", "levels", "may", "be", "helpful", "in", "the", "differential", "diagnosis", "C0243025#ent", "<e2>", "."], "h": {"id": "C1416681", "name": "C1416681#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243025", "name": "C0243025#ent", "pos": [12, 13]}}
{"token": ["Currently", ",", "these", "data", "are", "only", "available", "for", "thiazide", "diuretics", "beta-blockers", "for", "most", "hypertensive", "patients", "with", "normal", "renal", "function", "for", "the", "dihydropyridine", "calcium", "channel", "blockers", "C0003364#ent", "<e1>", "patients", "with", "isolated", "C0221155#ent", "<e2>"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0221155", "name": "C0221155#ent", "pos": [30, 31]}}
{"token": ["Several", "trials", "performed", "in", "elderly", "patients", "have", "demonstrated", "that", "C0003364#ent", "<e1>", "effective", "in", "both", "systo-diastolic", "and", "isolated", "C0221155#ent", "<e2>", "reducing", "the", "incidence", "of", "fatal", "and", "nonfatal", "cardiovascular", "events"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0221155", "name": "C0221155#ent", "pos": [17, 18]}}
{"token": ["Oral", "C0009011#ent", "<e1>", "has", "proved", "useful", "as", "adjunctive", "therapy", "C0014553#ent", "<e2>", "myoclonic", "seizures", "and", "partial", "seizures"], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [9, 10]}}
{"token": ["The", "administration", "of", "1", "-", "2", "mg", "C0009011#ent", "<e1>", "resulted", "in", "the", "complete", "control", "of", "7/7", "C0014553#ent", "<e2>", "7/14", "Grand", "Mal", "and", "2/3", "partial", "complex", "cases", "."], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [16, 17]}}
{"token": ["Transfection", "of", "T-cells", "with", "a", "C0907533#ent", "<e1>", "active", "form", "Rho", "(", ")", "blocks", "the", "clustering", "of", "C1706332#ent", "<e2>", "on", "the", "membrane", "and", "the", "LFA-1-mediated", "activation", "of", "PYK2", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706332", "name": "C1706332#ent", "pos": [16, 17]}}
{"token": ["Consequently", ",", "we", "examined", "the", "C0907533#ent", "<e1>", "expression", "of", "C1706332#ent", "<e2>", "and", "ICAM-1", "in", "postnatal", "human", "thymus", "from", "children", "with", "Down", "syndrome", "trisomy", "21", "DS", ")", "and", "age-matched", "control", "children", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706332", "name": "C1706332#ent", "pos": [9, 10]}}
{"token": ["Resting", "BAL", "CD4+", "T", "cells", "C0907533#ent", "<e1>", "express", "high", "levels", "of", "HLA-DP", ",", "lymphocyte", "function-associated", "antigen", "1", "C1706332#ent", "<e2>", ")", "and", "ICAM-3", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706332", "name": "C1706332#ent", "pos": [17, 18]}}
{"token": ["In", "the", "present", "studies", ",", "we", "have", "expressed", "the", "entire", "coding", "sequences", "the", "C0919487#ent", "<e1>", "oncogene", "as", "well", "as", "its", "C1416809#ent", "<e2>", "Escherichia", "coli"], "h": {"id": "C0919487", "name": "C0919487#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416809", "name": "C1416809#ent", "pos": [20, 21]}}
{"token": ["C0919487#ent", "<e1>", "constructs", ",", "progressively", "truncated", "in", "the", "C1416809#ent", "<e2>", "were", "prepared", "as", "GFP", "chimerae", "in", "order", "to", "identify", "which", "part", "of", "the", "receptor", "intracellular", "domain", "involved", "in", "its", "trafficking", "."], "h": {"id": "C0919487", "name": "C0919487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416809", "name": "C1416809#ent", "pos": [8, 9]}}
{"token": ["Past", "work", "showed", "induction", "of", "Nix", "transcripts", "a", "cellular", "model", "C1868675#ent", "<e1>", "on", "neuronal", "PC12", "cells", "exposed", "to", "C0085196#ent", "<e2>", "."], "h": {"id": "C1868675", "name": "C1868675#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085196", "name": "C0085196#ent", "pos": [18, 19]}}
{"token": ["C0700583#ent", "<e1>", "one", "of", "the", "potent", "C0003212#ent", "<e2>", "NSAID", ")", "used", "in", "the", "treatment", "of", "inflammatory", "conditions"], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003212", "name": "C0003212#ent", "pos": [6, 7]}}
{"token": ["The", "effectiveness", "and", "selectivity", "of", "both", "antagonists", "was", "confirmed", "by", "testing", "them", "against", "contractions", "in", "response", "to", "the", "C0360055#ent", "<e1>", "2-methyl-5-HT", ",", "and", "the", "C2936516#ent", "<e2>", "5-methoxytryptamine", "."], "h": {"id": "C0360055", "name": "C0360055#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2936516", "name": "C2936516#ent", "pos": [24, 25]}}
{"token": ["A", "51-year-old", "man", "developed", "C0030809#ent", "<e1>", "minimal", "change", "C0022658#ent", "<e2>", "and", "acute", "tubular", "necrosis", "11", "months", "of", "treatment", "with", "penicillamine", "for", "rheumatoid", "arthritis", "associated", "with", "features", "of", "Reiter's", "syndrome"], "h": {"id": "C0030809", "name": "C0030809#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [8, 9]}}
{"token": ["The", "C0002763#ent", "<e1>", "of", "antibody", "producers", "(", "C2699241#ent", "<e2>", ")", "was", "eluated", "at", "the", "site", "of", "cytochrome", "C", "exit", "the", "factor", "is", "heat-stable", "and", "has", "the", "mol", "wt", "of", "1300", "daltons", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2699241", "name": "C2699241#ent", "pos": [7, 8]}}
{"token": ["C0795998#ent", "<e1>", "JWS", ")", "is", "a", "condition", "consisting", "of", "C0010278#ent", "<e2>", "characterized", "by", "premature", "fusion", "the", "cranial", "sutures", "characteristic", "radiographic", "anomalies", "the", "feet", "."], "h": {"id": "C0795998", "name": "C0795998#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [9, 10]}}
{"token": ["In", "C1321914#ent", "<e1>", "p47(phox", ")", "phosphorylation", ",", "GF109203X", ",", "a", "C1415545#ent", "<e2>", "strongly", "inhibits", "p47(phox", ")", "phosphorylation", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415545", "name": "C1415545#ent", "pos": [10, 11]}}
{"token": ["C1321914#ent", "<e1>", "inactivation", "of", "TIS11", "was", "blocked", "by", "calphostin", "C", "a", "C1415545#ent", "<e2>", "and", "PD98059", ",", "a", "mitogen-activated", "protein", "MAP", ")", "kinase", "kinase", "inhibitor"], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415545", "name": "C1415545#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "(", "C0272192#ent", "<e1>", ")", ",", "a", "gamma-aminobutyric", "acid", "(GABA)-transaminase", "blocker", "on", "C0242898#ent", "<e2>", "postsynaptic", "and", "presynaptic", "inhibitory", "neurotransmission", "were", "examined", "in", "the", "crayfish", "opener", "neuromuscular", "synapses"], "h": {"id": "C0272192", "name": "C0272192#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [14, 15]}}
{"token": ["These", "data", "suggest", "that", "sequences", "N", "terminal", "to", "the", "C0812252#ent", "<e1>", "regulate", "binding", "activity", "tyrosine-phosphorylated", "proteins", "that", "the", "C3539946#ent", "<e2>", "encoded", "immediately", "5", "'", "to", "the", "c-Crk", "initiator", "AUG", "specifically", "increase", "binding", "affinity", "."], "h": {"id": "C0812252", "name": "C0812252#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [18, 19]}}
{"token": ["Migratory", "effector", "cells", "downregulate", "activation", "markers", "C1334114#ent", "<e1>", ",", "OX-40", ")", "but", "upregulate", "several", "chemokine", "receptors", "adsorb", "C0017349#ent", "<e2>", "their", "membranes", "."], "h": {"id": "C1334114", "name": "C1334114#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017349", "name": "C0017349#ent", "pos": [17, 18]}}
{"token": ["Subsequently", ",", "the", "dose", "of", "C0594375#ent", "<e1>", "was", "reduced", "to", "200", "mg/m2", "in", "view", "of", "C0009952#ent", "<e2>", "neutropenia", "in", "one", "of", "five", "patients", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [15, 16]}}
{"token": ["Rats", "were", "treated", "as", "neonates", "or", "adults", "with", "desmethylimipramine", "(", "C0011685#ent", "<e1>", ")", "followed", "by", "intraventricular", "6-hydroxydopamine", "6-HDA", ")", "or", "5,7", "C0012338#ent", "<e2>", "(", "5,7-DHT", ")", "."], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012338", "name": "C0012338#ent", "pos": [21, 22]}}
{"token": ["C1414562#ent", "<e1>", "de-phosphorylates", "the", "RNA", "polymerase", "II", "RNAPII", ")", "C-terminal", "domain", "C1335071#ent", "<e2>", ")", "in", "vitro", "and", "mutation", "of", "the", "yeast", "FCP1", "gene", "results", "in", "global", "transcription", "defects", "and", "increased", "C1335071#ent", "<e2>", "phosphorylation", "levels", "in", "vivo"], "h": {"id": "C1414562", "name": "C1414562#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335071", "name": "C1335071#ent", "pos": [11, 12]}}
{"token": ["C1414562#ent", "<e1>", "is", "an", "essential", "protein", "serine", "phosphatase", "dephosphorylates", "the", "C-terminal", "domain", "C1335071#ent", "<e2>", ")", "of", "RNA", "polymerase", "II"], "h": {"id": "C1414562", "name": "C1414562#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335071", "name": "C1335071#ent", "pos": [12, 13]}}
{"token": ["C1414562#ent", "<e1>", "is", "an", "essential", "protein", "phosphatase", "hydrolyzes", "phosphoserines", "within", "the", "C-terminal", "domain", "C1335071#ent", "<e2>", ")", "of", "the", "largest", "subunit", "of", "RNA", "polymerase", "II", "Pol", "II", "."], "h": {"id": "C1414562", "name": "C1414562#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335071", "name": "C1335071#ent", "pos": [13, 14]}}
{"token": ["Our", "data", "suggest", "that", "the", "association", "of", "C1414562#ent", "<e1>", "with", "elongating", "polymerase", "in", "C1335071#ent", "<e2>", "de-phosphorylation", "when", "the", "native", "ternary", "RNAPII0-DNA-RNA", "complex", "is", "disrupted", "."], "h": {"id": "C1414562", "name": "C1414562#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335071", "name": "C1335071#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "an", "C1970173#ent", "<e1>", "the", "disease", "features", "of", "C0020616#ent", "<e2>", ",", "hyperammonemia", ",", "tissue", "fatty", "change", "hypoketonemia", ",", "carnitine", "deficiency", "and", "organic", "acidemia", "to", "apparent", "disruption", "of", "normal", "fatty", "acid", "glucose", ",", "and", "urea", "metabolism"], "h": {"id": "C1970173", "name": "C1970173#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [9, 10]}}
{"token": ["C1412820#ent", "<e1>", "61063", "is", "a", "novel", "xanthine", "phosphodiesterase", "C0031640#ent", "<e2>", ")", "type", "IV", "inhibitor", "with", "selective", "inhibitory", "activity", "for", "tumor", "necrosis", "factor", "TNF", ")", "alpha", "production", "."], "h": {"id": "C1412820", "name": "C1412820#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [8, 9]}}
{"token": ["Our", "observations", "suggest", "that", "C0024141#ent", "<e1>", "anti-DNA", "antibodies", "from", "an", "C0221406#ent", "<e2>", "of", "autoantibodies", "that", "are", "present", "in", "normal", "people"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [10, 11]}}
{"token": ["Conversely", ",", "p53", "C0039052#ent", "<e1>", "to", "stabilize", "the", "C2987364#ent", "<e2>", "conformation", "of", "p53", "sensitize", "glioma", "cells", "TMZ", "cytotoxicity", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}}
{"token": ["Ragweed", "antigen", "stimulated", "[3H]ACh", "release", "and", "contraction", "in", "C2697834#ent", "<e1>", "but", "not", "C1419876#ent", "<e2>", "tissues", "."], "h": {"id": "C2697834", "name": "C2697834#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419876", "name": "C1419876#ent", "pos": [12, 13]}}
{"token": ["C0048470#ent", "<e1>", "treatment", "improved", "C0040034#ent", "<e2>", "and", "hypercoagulable", "state"], "h": {"id": "C0048470", "name": "C0048470#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [4, 5]}}
{"token": ["This", "case", "report", "the", "use", "of", "C0048470#ent", "<e1>", ",", "an", "anticoagulant", "and", "thrombin", "inhibitor", "treatment", "of", "C0040034#ent", "<e2>", "in", "an", "adult", "patient", "on", "extracorporeal", "membrane", "oxygenation", "ECMO", ")", "."], "h": {"id": "C0048470", "name": "C0048470#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [16, 17]}}
{"token": ["The", "frequency", "of", "endotoxemia", ",", "gram", "negative", "bacteremia", "C0012739#ent", "<e1>", "hepatic", "failure", "significantly", "higher", "in", "severe", "cholangitis", "than", "in", "C0008311#ent", "<e2>"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [19, 20]}}
{"token": ["Plasmapheresis", "was", "used", "as", "a", "complement", "to", "conventional", "therapy", "a", "patient", "with", "multiorgan", "failure", "C0012739#ent", "<e1>", "DIC", ")", "following", "biliary", "obstruction", "C0008311#ent", "<e2>"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [21, 22]}}
{"token": ["To", "study", "the", "localization", ",", "etiological", "agents", "the", "respective", "prognosis", "in", "patients", "with", "C0014121#ent", "<e1>", "or", "without", "neurological", "complications", "with", "emphasis", "on", "the", "association", "of", "C0014118#ent", "<e2>", "and", "meningitis", "."], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [25, 26]}}
{"token": ["Twenty", "patients", "entered", "the", "study", ",", "twelve", "with", "C0014121#ent", "<e1>", "six", "without", "any", "bacteremia", "and", "two", "septicemic", "patients", "without", "C0014118#ent", "<e2>", "."], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [19, 20]}}
{"token": ["The", "C0971654#ent", "<e1>", "PTP-Bas", ")", "and", "its", "mouse", "homologue", "PTP-Basophil-like", "(", "C1419096#ent", "<e2>", ")", ",", "are", "high", "molecular", "mass", "protein", "phosphatases", "consisting", "of", "a", "number", "of", "diverse", "protein-protein", "interaction", "modules"], "h": {"id": "C0971654", "name": "C0971654#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419096", "name": "C1419096#ent", "pos": [11, 12]}}
{"token": ["It", "has", "no", "inhibitory", "action", "towards", "trypsin", "or", "chymotrypsin", ",", "and", "is", "distinct", "from", "the", "inhibitors", "of", "those", "C3541394#ent", "<e1>", "found", "in", "pea", "seeds", ",", "nor", "does", "it", "inhibit", "C2350323#ent", "<e2>"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2350323", "name": "C2350323#ent", "pos": [29, 30]}}
{"token": ["Epinephrine-induced", "platelet", "aggregation", "blocked", "by", "phentolamine", ",", "C0724441#ent", "<e1>", ",", "dihydroergotamine", ",", "clonidine", "and", "lofexidine", "but", "not", "by", "C0031441#ent", "<e2>", "(", "1", "X", "10(-5", ")", "M", ")", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031441", "name": "C0031441#ent", "pos": [18, 19]}}
{"token": ["pretreatment", "of", "rats", "with", "C0724441#ent", "<e1>", ",", "an", "alpha", "2-adrenergic", "antagonist", "and", "was", "antagonized", "by", "pretreatment", "with", "C0031441#ent", "<e2>", ",", "an", "alpha", "1-adrenergic", "antagonist"], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031441", "name": "C0031441#ent", "pos": [17, 18]}}
{"token": ["Finally", ",", "C1334089#ent", "<e1>", "inhibition", "of", "JNK", "phosphorylation", "was", "blocked", "by", "the", "C2347168#ent", "<e2>", "PD98059", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2347168", "name": "C2347168#ent", "pos": [12, 13]}}
{"token": ["The", "C1257883#ent", "<e1>", "Galphas", "and", "Gbeta", ",", "are", "associated", "with", "C0080298#ent", "<e2>", "in", "basal", "conditions", "and", "this", "association", "increases", "two-", "to", "threefold", "in", "cells", "treated", "with", "PTH", "."], "h": {"id": "C1257883", "name": "C1257883#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [10, 11]}}
{"token": ["We", "have", "used", "this", "cell", "line", "investigate", "the", "role", "of", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e1>", "in", "integrating", "C0105421#ent", "<e2>", "and", "CD40", "signaling", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [18, 19]}}
{"token": ["The", "C1567723#ent", "<e1>", "UGTs", ")", "involved", "in", "the", "glucuronidation", "of", "C0672211#ent", "<e2>", "were", "determined", "in", "this", "study", "."], "h": {"id": "C1567723", "name": "C1567723#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0672211", "name": "C0672211#ent", "pos": [10, 11]}}
{"token": ["For", "evaluation", "of", "the", "effect", "of", "metabolic", "acidosis", "the", "intratubular", "complement", "activation", "urinary", "CAP", "were", "measured", "before", "and", "after", "C2930448#ent", "<e1>", "administration", "in", "patients", "with", "C1565489#ent", "<e2>"], "h": {"id": "C2930448", "name": "C2930448#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [25, 26]}}
{"token": ["The", "clinical", "efficacy", "tolerability", "of", "simvastatin", "and", "C0246203#ent", "<e1>", "were", "compared", "in", "432", "patients", "with", "C0342879#ent", "<e2>", "a", "multinational", ",", "randomised", ",", "double-blind", "trial"], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342879", "name": "C0342879#ent", "pos": [15, 16]}}
{"token": ["By", "contrast", ",", "C1161331#ent", "<e1>", "feeding", "had", "no", "effects", "these", "measurements", "in", "rats", "treated", "with", "C0085196#ent", "<e2>"], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085196", "name": "C0085196#ent", "pos": [15, 16]}}
{"token": ["The", "same", "injections", ",", "however", ",", "failed", "to", "increase", "intake", "of", "the", "0.1", "M", "C1161331#ent", "<e1>", "in", "rats", "with", "C0085196#ent", "<e2>", "lesions", "of", "the", "VTA", "."], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085196", "name": "C0085196#ent", "pos": [19, 20]}}
{"token": ["Lower", "doses", "C0042523#ent", "<e1>", "were", "not", "C0007209#ent", "<e2>", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [6, 7]}}
{"token": ["Before", "and", "during", "a", "standardized", "course", "of", "C0040979#ent", "<e1>", "18", "schizophrenic", "patients", "underwent", "repeated", "examinations", "for", "C0234132#ent", "<e2>", "clinical", "psychopathology", "and", "urinary", "excretion", "free", "and", "conjugated", "forms", "of", "dopamine", "and", "its", "metabolites", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0234132", "name": "C0234132#ent", "pos": [16, 17]}}
{"token": ["Five", "patients", "with", "idiopathic", "generalized", "epilepsy", "C1415975#ent", "<e1>", ")", "were", "studied", "at", "rest", "and", "during", "absence", "C0751495#ent", "<e2>", "with", "[11C]flumazenil", "and", "positron", "emission", "tomography", "PET", ")", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [16, 17]}}
{"token": ["The", "C3814041#ent", "<e1>", "gene", "is", "adjacent", "to", "the", "C1705753#ent", "<e2>", "and", "like", "IL-2", ",", "C3814041#ent", "<e1>", "is", "strongly", "induced", "at", "the", "transcriptional", "level", "after", "T", "cell", "activation", "."], "h": {"id": "C1705753", "name": "C1705753#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3814041", "name": "C3814041#ent", "pos": [1, 2]}}
{"token": ["The", "C0679247#ent", "<e1>", "of", "40", "patients", "with", "diagnoses", "of", "C0243026#ent", "<e2>", ",", "cellulitis", "with", "bacteremia", ",", "pneumonia", "empyema", "and", "meningitis", "caused", "by", "Streptococcus", "pyogenes", "Group", "A", "are", "described", "."], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [9, 10]}}
{"token": ["Inflammatory", "dysregulation", "is", "believed", "to", "contribute", "to", "mortality", "and", "morbidity", "in", "C0679247#ent", "<e1>", "common", "to", "critical", "care", "units", "such", "as", "burns", ",", "trauma", ",", "C0243026#ent", "<e2>", ",", "and", "cardiovascular", "disease"], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [24, 25]}}
{"token": ["The", "Adult", "Respiratory", "Distress", "Syndrome", "a", "complication", "of", "many", "C0679247#ent", "<e1>", "such", "as", "C0243026#ent", "<e2>", ",", "pneumonia", "and", "trauma", "afflicting", "over", "150,000", "patients", "per", "year", "."], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [13, 14]}}
{"token": ["Since", "the", "C0142751#ent", "<e1>", "assembles", "into", "three", "complexes", "that", "differ", "in", "their", "beta", "subunit", "identity", ",", "the", "possibility", "exists", "that", "each", "upstream", "kinase", "be", "dedicated", "to", "a", "single", "C0597298#ent", "<e2>", "of", "the", "C0142751#ent", "<e1>"], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0142751", "name": "C0142751#ent", "pos": [2, 3]}}
{"token": ["It", "has", "been", "recognized", "for", "more", "than", "20", "years", "that", "the", "macrolides", "have", "immunomodulatory", "effects", "are", "beneficial", "for", "those", "suffering", "from", "chronic", "pulmonary", "inflammatory", "syndromes", "such", "as", "C0878555#ent", "<e1>", "cystic", "fibrosis", "asthma", "and", "C0006267#ent", "<e2>", "."], "h": {"id": "C0878555", "name": "C0878555#ent", "pos": [27, 28]}, "relation": "has_manifestation", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [33, 34]}}
{"token": ["The", "subjects", "consisted", "of", "1", "case", "of", "C0878555#ent", "<e1>", "and", "3", "cases", "of", "C0006267#ent", "<e2>", "."], "h": {"id": "C0878555", "name": "C0878555#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [13, 14]}}
{"token": ["Three", "of", "the", "cases", "showed", "C4072868#ent", "<e1>", "the", "upper", "edge", "the", "C0155359#ent", "<e2>", "in", "the", "same", "location", "as", "the", "neovascular", "net", "."], "h": {"id": "C4072868", "name": "C4072868#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0155359", "name": "C0155359#ent", "pos": [11, 12]}}
{"token": ["Both", "C0085752#ent", "<e1>", "and", "aclarubicin", "inhibit", "C0012863#ent", "<e2>", ",", "thus", ",", "C0012863#ent", "<e2>", "not", "be", "a", "major", "factor", "in", "the", "acquired", "resistance", "C0085752#ent", "<e1>", "that", "results", "from", "overexpression", "of", "Ssl2p", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [6, 7]}}
{"token": ["The", "processes", "involved", "in", "cell", "killing", "C0085752#ent", "<e1>", "(", "ADR", ")", "and", "other", "agents", "that", "interact", "with", "C0012863#ent", "<e2>", "unclear", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [17, 18]}}
{"token": ["The", "anticancer", "anthracycline", "C0085752#ent", "<e1>", "is", "a", "known", "C0012863#ent", "<e2>", "inhibitor", "but", "is", "also", "capable", "of", "exerting", "other", "cellular", "consequences", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [8, 9]}}
{"token": ["The", "data", "analysis", "shows", "that", "prediction", "of", "C0085752#ent", "<e1>", "resistance", "based", "on", "lack", "of", "C0012863#ent", "<e2>", "expression", "will", "not", "be", "very", "accurate", ",", "in", "contrast", "to", "a", "previous", "claim", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [14, 15]}}
{"token": ["The", "concentration", "of", "a", "marginal", "population", "35", "%", "drug", "addicts", "in", "prisons", "necessitates", "systematic", "and", "C0026837#ent", "<e1>", "screening", "for", "hepatitis", "B", "C0019196#ent", "<e2>", "subjects", "at", "risk", "."], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019196", "name": "C0019196#ent", "pos": [21, 22]}}
{"token": ["C0271742#ent", "<e1>", "isolated", "glucocorticoid", "deficiency", "achalasia", "and", "C0344505#ent", "<e2>", ")", "was", "found", "in", "eight", "members", "of", "an", "inbred", "French", "Canadian/North", "American", "Indian", "pedigree", "."], "h": {"id": "C0271742", "name": "C0271742#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0344505", "name": "C0344505#ent", "pos": [7, 8]}}
{"token": ["Triple", "A", "C0271742#ent", "<e1>", "a", "rare", "autosomal", "recessive", "disease", "C0344505#ent", "<e2>", ",", "achalasia", ",", "and", "ACTH-resistant", "adrenal", "insufficiency"], "h": {"id": "C0271742", "name": "C0271742#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0344505", "name": "C0344505#ent", "pos": [9, 10]}}
{"token": ["The", "triple", "A", "syndrome", "caused", "by", "mutations", "in", "the", "C0271742#ent", "<e1>", "which", "encodes", "a", "protein", "known", "as", "ALADIN", "(", "C0344505#ent", "<e2>", "aDrenal", "Insufficiency", "Neurologic", "disorder", "."], "h": {"id": "C0271742", "name": "C0271742#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0344505", "name": "C0344505#ent", "pos": [19, 20]}}
{"token": ["C0669372#ent", "<e1>", "from", "SGA", "and", "C1412276#ent", "<e2>", "piglets", "were", "equally", "capable", "of", "satisfying", "greater", "than", "75", "%", "of", "their", "energy", "needs", "from", "fatty", "acid", "oxidation"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412276", "name": "C1412276#ent", "pos": [5, 6]}}
{"token": ["In", "the", "present", "study", ",", "we", "evaluated", "the", "efficacy", "of", "BoNT/A", "injections", "into", "the", "CP", "muscle", "diabetic", "patients", "with", "severe", "C0267071#ent", "<e1>", "associated", "with", "diabetic", "autonomic", "and/or", "somatic", "C0031117#ent", "<e2>"], "h": {"id": "C0267071", "name": "C0267071#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [28, 29]}}
{"token": ["C1705543#ent", "<e1>", "increased", "free", "radical", "production", "lipid", "peroxidation", "PC12", "nerve", "cells", "leading", "to", "increased", "4-hydroxy-2-nonenal", "(", "C1414369#ent", "<e2>", ")", "production", "and", "modification", "of", "specific", "mitochondrial", "target", "proteins", "apoptosis", "and", "cell", "death"], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414369", "name": "C1414369#ent", "pos": [16, 17]}}
{"token": ["C1166521#ent", "<e1>", "is", "also", "thought", "to", "mediate", "the", "cardiotoxic", "and", "antitumour", "effects", "C0014582#ent", "<e2>", "and", "related", "compounds", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [12, 13]}}
{"token": ["This", "study", ",", "based", "on", "in", "situ", "hybridization", "immunolabeling", "experiments", ",", "presents", "the", "time-course", "and", "cellular", "distribution", "of", "C0669372#ent", "<e1>", "iNOS", ")", "expression", "in", "a", "rat", "model", "of", "C0014038#ent", "<e2>"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [28, 29]}}
{"token": ["Here", "the", "expression", "of", "C0669372#ent", "<e1>", "and", "synthesis", "of", "NO", "was", "studied", "in", "C0014038#ent", "<e2>", "cattle", ",", "sheep", ",", "and", "goats", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [13, 14]}}
{"token": ["Personality", "traits", "assessed", "by", "the", "Temperament", "and", "Character", "Inventory", "C1420652#ent", "<e1>", ")", ",", "and", "the", "two", "mutated", "alleles", "absent", "C0960580#ent", "<e2>", "identified", "by", "a", "PCR-RFLP", "method", "."], "h": {"id": "C1420652", "name": "C1420652#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [19, 20]}}
{"token": ["We", "have", "rather", "to", "conclude", "that", "C0039957#ent", "<e1>", "may", "exert", "its", "effect", "mainly", "through", "a", "direct", "competitive", "C0027203#ent", "<e2>", "inhibition", "."], "h": {"id": "C0039957", "name": "C0039957#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}}
{"token": ["Both", "Bcl-2", "up-regulation", "and", "Bax", "translocation", "estrogen", "receptor-dependent", "events", ";", "however", ",", "Bcl-2", "augmentation", "but", "not", "Bax", "translocation", "dependent", "on", "C0001477#ent", "<e1>", "increase", ",", "activation", "of", "C0033634#ent", "<e2>", "and", "ERK", "phosphorylation", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [26, 27]}}
{"token": ["Addition", "of", "GnRH-A", "resulted", "in", "a", "3-fold", "increase", "in", "alphaCAT", ",", "whereas", "the", "C0001477#ent", "<e1>", "ionophore", "ionomycin", "and", "the", "C0033634#ent", "<e2>", "PKC", ")", "activator", "12-O-tetradecanoylphorbol-13-acetate", "TPA", ")", "had", "no", "effect"], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [19, 20]}}
{"token": ["C3273395#ent", "<e1>", "was", "a", "small", "C1413766#ent", "<e2>", "no", "significant", "homology", "to", "known", "proteins", "."], "h": {"id": "C3273395", "name": "C3273395#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413766", "name": "C1413766#ent", "pos": [5, 6]}}
{"token": ["The", "effect", "of", "GABA", "C0243192#ent", "<e1>", ",", "namely", "gamma", "aminobutyric", "acid", "muscimol", ",", "C0037567#ent", "<e2>", "baclofen", "was", "studied", "on", "radiant", "heat-induced", "nociception", "in", "mice", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [13, 14]}}
{"token": ["A", "32", "year", "old", "pregnant", "woman", "who", "had", "taken", "large", "doses", "of", "theophylline", "for", "C0004096#ent", "<e1>", "brought", "to", "our", "emergency", "medical", "center", "C4048158#ent", "<e2>", "and", "respiratory", "disturbance"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [22, 23]}}
{"token": ["The", "contractile", "response", "C0031469#ent", "<e1>", "was", "antagonized", "by", "C0006403#ent", "<e2>", "and", "SR", "59230A", "in", "a", "competitive", "manner", "(", "pA2", ":", "6.38", "and", "7.08", "respectively", ")", "."], "h": {"id": "C0031469", "name": "C0031469#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006403", "name": "C0006403#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "indicate", "that", "C1413452#ent", "<e1>", "might", "be", "involved", "in", "modulating", "vascular", "remodeling", "hypertension", "and", "C0003850#ent", "<e2>", "."], "h": {"id": "C1413452", "name": "C1413452#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [15, 16]}}
{"token": ["C0033228#ent", "<e1>", "is", "among", "the", "drugs", "of", "choice", "for", "treatment", "of", "C0020557#ent", "<e2>", "and", "low", "levels", "of", "high-density", "lipoprotein", "(HDL)-cholesterol", "both", "recognised", "as", "risk", "factors", "cardiovascular", "disease"], "h": {"id": "C0033228", "name": "C0033228#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [11, 12]}}
{"token": ["Diphenhydramine", "(", "10", "and", "20", "mg/kg", ")", "and", "diphenidol", "(", "30", "mg/kg", ")", "inhibited", "C0264435#ent", "<e1>", "intake", "induced", "by", "60-min", "double", "rotation", "while", "domperidone", "and", "C0061851#ent", "<e2>", "did", "not", "."], "h": {"id": "C0264435", "name": "C0264435#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0061851", "name": "C0061851#ent", "pos": [25, 26]}}
{"token": ["The", "breakpoint", "of", "16p13", "has", "several", "hematopoietic", "neoplasm-related", "genes", "such", "as", "MHC2TA", ",", "a", "C0017362#ent", "<e1>", "HLA-D", ",", "and", "BCMA", ",", "C1336652#ent", "<e2>"], "h": {"id": "C0017362", "name": "C0017362#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1336652", "name": "C1336652#ent", "pos": [21, 22]}}
{"token": ["We", "show", "that", "different", "Sprouty", "genes", "deployed", "in", "different", "tissue", "compartments", "C1420383#ent", "<e1>", "in", "epithelium", "and", "C3542431#ent", "<e2>", "in", "mesenchyme", "--", "to", "prevent", "diastema", "tooth", "."], "h": {"id": "C1420383", "name": "C1420383#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3542431", "name": "C3542431#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "we", "show", "that", "the", "human", "C1413287#ent", "<e1>", "gene", "product", "a", "novel", "C0243045#ent", "<e2>", "cdk6", "."], "h": {"id": "C1413287", "name": "C1413287#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [13, 14]}}
{"token": ["v-Cyclin", "exhibited", "a", "selective", "preference", "for", "association", "with", "C1413287#ent", "<e1>", "over", "other", "C0243045#ent", "<e2>", "a", "high", "level", "of", "kinase", "activation"], "h": {"id": "C1413287", "name": "C1413287#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [12, 13]}}
{"token": ["These", "results", "would", "suggest", "that", "C0002697#ent", "<e1>", "is", "a", "positive", "C0597058#ent", "<e2>", "vasodilating", "properties", "at", "higher", "doses", ",", "and", "weak", "positive", "chronotropic", "effect", "."], "h": {"id": "C0002697", "name": "C0002697#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597058", "name": "C0597058#ent", "pos": [10, 11]}}
{"token": ["The", "two", "proteins", "were", "strong", "inhibitors", "of", "C3539768#ent", "<e1>", "assessed", "in", "vitro", "porcine", "C1418617#ent", "<e2>", "[3H]-oleic", "acid", "labeled", "E.", "Coli", "membranes", "as", "substrate", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418617", "name": "C1418617#ent", "pos": [13, 14]}}
{"token": ["Similarly", ",", "partially", "purified", "C3539768#ent", "<e1>", "horse", "seminal", "fluid", "not", "affected", "by", "antibodies", "raised", "against", "C1418617#ent", "<e2>"], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418617", "name": "C1418617#ent", "pos": [15, 16]}}
{"token": ["These", "results", "demonstrated", "the", "existence", "of", "a", "C1418617#ent", "<e1>", "a", "non-pancreatic", "organ", "as", "a", "member", "of", "the", "C3539768#ent", "<e2>", "suggest", "the", "potential", "functional", "involvement", "of", "C1418617#ent", "<e1>", "cellular", "phospholipid", "metabolism"], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418617", "name": "C1418617#ent", "pos": [7, 8]}}
{"token": ["The", "C1413096#ent", "<e1>", "Ku", ",", "composed", "of", "subunits", "C1311257#ent", "<e2>", "and", "Ku86", ",", "is", "necessary", "for", "repair", "of", "DNA", "double-strand", "breaks", "nonhomologous", "end", "joining"], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1311257", "name": "C1311257#ent", "pos": [8, 9]}}
{"token": ["HUVEC", "and", "HAVEC", "cultures", "were", "exposed", "to", "phorbol", "ester", "PMA", ")", ",", "endotoxin", "(", "C0175697#ent", "<e1>", ")", "or", "thrombin", ",", "singly", "or", "in", "combination", "with", "C0917964#ent", "<e2>", "or", "H7", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [25, 26]}}
{"token": ["C0175697#ent", "<e1>", "also", "inhibited", "cAMP", "accumulation", "in", "cells", "treated", "with", "microM", "C0917964#ent", "<e2>", ",", "but", "the", "decrease", "was", "about", "half", "that", "seen", "in", "cells", "treated", "with", "PGE2", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [11, 12]}}
{"token": ["Oviductal", "extracts", "oviductal", "fluids", "obtained", "from", "C0152149#ent", "<e1>", "analysed", "by", "immunoblotting", "for", "the", "presence", "of", "C0072522#ent", "<e2>", "that", "cross-react", "with", "a", "monoclonal", "antibody", "MAb", ")", "against", "GHOGPs", "."], "h": {"id": "C0152149", "name": "C0152149#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [15, 16]}}
{"token": ["Although", "both", "uterus", "and", "kidney", "are", "targets", "of", "sex", "hormones", "our", "results", "indicate", "that", "estrogen", "and", "C3536949#ent", "<e1>", "have", "differential", "influences", "on", "the", "C1704862#ent", "<e2>", "activity", "in", "these", "two", "organs", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704862", "name": "C1704862#ent", "pos": [23, 24]}}
{"token": ["The", "C3536949#ent", "<e1>", "dependent", "nature", "of", "C1704862#ent", "<e2>", ",", "fructose", "and", "sialic", "acid", "been", "demonstrated", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704862", "name": "C1704862#ent", "pos": [6, 7]}}
{"token": ["The", "endogenous", "system", "was", "manipulated", "by", "icv", "infusion", "of", "C0036193#ent", "<e1>", ",", "an", "Ang", "II", "receptor", "antagonist", "or", "icv", "injection", "of", "C0014025#ent", "<e2>", ",", "a", "converting", "enzyme", "inhibitor", "to", "prevent", "synthesis", "of", "Ang", "II"], "h": {"id": "C0036193", "name": "C0036193#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [21, 22]}}
{"token": ["When", "the", "effect", "of", "endogenous", "angiotensin", "II", "antagonized", "by", "C0036193#ent", "<e1>", "or", "its", "production", "was", "blocked", "by", "C0014025#ent", "<e2>", ",", "the", "AVP", "response", "to", "tilt", "was", "reduced", "."], "h": {"id": "C0036193", "name": "C0036193#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [17, 18]}}
{"token": ["The", "retinoblastoma", "tumor", "suppressor", "gene", "C0694889#ent", "<e1>", ",", "and", "the", "C0525678#ent", "<e2>", "proto-oncogenes", "regulate", "various", "cellular", "processes", "including", "differentiation", "and", "proliferation", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}}
{"token": ["C0272285#ent", "<e1>", "reported", "in", "three", "patients", "with", "C0041327#ent", "<e2>"], "h": {"id": "C0272285", "name": "C0272285#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [7, 8]}}
{"token": ["Our", "interest", ",", "from", "the", "clinical", "point", "of", "view", "consists", "of", "correlating", "this", "tendency", "in", "vitro", "its", "effect", "in", "vivo", "the", "development", "of", "drugs", "and", "formulations", "for", "the", "treatment", "of", "dry", "skin", "syndrome", "C0012634#ent", "<e1>", "accompanied", "by", "C0720057#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [33, 34]}, "relation": "NA", "t": {"id": "C0720057", "name": "C0720057#ent", "pos": [37, 38]}}
{"token": ["Based", "on", "the", "results", "of", "this", "and", "previous", "studies", "we", "offer", "an", "explanation", "for", "the", "deviation", "in", "lipid", "organization", "C0012634#ent", "<e1>", "and", "in", "C0720057#ent", "<e2>", "to", "normal", "skin"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0720057", "name": "C0720057#ent", "pos": [23, 24]}}
{"token": ["C0043355#ent", "<e1>", "leads", "to", "an", "increase", "of", "K+", "and", "C1417500#ent", "<e2>", "+", "excretion", ",", "but", "to", "a", "decrease", "of", "Ca2", "+", "excretion", "in", "urine", ",", "a", "charactaristical", "feature", "of", "the", "thiazide-like", "diuretics"], "h": {"id": "C0043355", "name": "C0043355#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [9, 10]}}
{"token": ["These", "data", "indicate", "that", ",", "in", "addition", "to", "calcium", "at", "neutral", "pH", ",", "copper", "(", "and", "zinc", ")", "at", "neutral", "and", "particularly", "C0815040#ent", "<e1>", "pH", "values", "mediates", "C1456795#ent", "<e2>", "binding", "to", "polysaccharide", "ligands"], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [27, 28]}}
{"token": ["Sodium", "absorption", "C1963718#ent", "<e1>", "60:240", "and", "C0078516#ent", "<e2>", "was", "similar", "and", "greater", "than", "sodium", "absorption", "C1963718#ent", "<e1>", "45:210", "(", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C0078516", "name": "C0078516#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1963718", "name": "C1963718#ent", "pos": [2, 3]}}
{"token": ["All", "experimental", "C1963718#ent", "<e1>", "formulations", "contained", "the", "same", "concentrations", "of", "salts", "as", "citrate-based", "C0078516#ent", "<e2>", ";", "all", "trials", "were", "randomized", "comparisons", "C0078516#ent", "<e2>", ",", "and", "all", "except", "those", "with", "rice-based", "C1963718#ent", "<e1>", "were", "double-blind", "studies"], "h": {"id": "C0078516", "name": "C0078516#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1963718", "name": "C1963718#ent", "pos": [2, 3]}}
{"token": ["Recent", "progress", "has", "enabled", "research", "to", "demonstrate", "genetically", "that", "NOD2", "(", "C2698415#ent", "<e1>", ")", "is", "involved", "in", "the", "predisposition", "to", "Crohn's", "disease", "C1861303#ent", "<e2>"], "h": {"id": "C2698415", "name": "C2698415#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1861303", "name": "C1861303#ent", "pos": [22, 23]}}
{"token": ["On", "the", "other", "hand", ",", "C0042523#ent", "<e1>", "showed", "moderate", "improvement", "of", "his", "C0270697#ent", "<e2>", ",", "then", "the", "symptons", "was", "gradually", "getting", "better", "and", "finally", "he", "felt", "no", "pain"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [12, 13]}}
{"token": ["The", "class", "II", "deacetylase", "(", "HDAC", ")", ",", "C1333893#ent", "<e1>", ",", "is", "expressed", "in", "a", "C1420295#ent", "<e2>", "manner", ",", "and", "it", "represses", "differentiation", "of", "specific", "cell", "types"], "h": {"id": "C1333893", "name": "C1333893#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [15, 16]}}
{"token": ["The", "dimer", "of", "MPP7", "with", "C1425075#ent", "<e1>", "or", "LIN7C", "associates", "with", "C1424603#ent", "<e2>", "through", "an", "interaction", "requiring", "the", "amino-terminal", "L27", "domain", "of", "MPP7", "."], "h": {"id": "C1425075", "name": "C1425075#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424603", "name": "C1424603#ent", "pos": [11, 12]}}
{"token": ["Breast", "and", "lung", "cancer", "cell", "lines", "treated", "with", "C0006812#ent", "<e1>", "and", "sodium", "butyrate", "NaB", ")", "or", "C0672708#ent", "<e2>", "the", "day", "of", ",", "the", "day", "before", ",", "or", "the", "day", "after", "C0006812#ent", "<e1>", "addition", "."], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0672708", "name": "C0672708#ent", "pos": [16, 17]}}
{"token": ["The", "development", "of", "SCLE-like", "cutaneous", "eruptions", "been", "associated", "with", "intake", "of", "drugs", "including", "thiazide", "diuretics", "calcium", "channel", "blockers", "angiotensin", "converting-enzyme", "inhibitors", "C0031507#ent", "<e1>", ",", "etanercept", ",", "antihistaminics", ",", "interferons", ",", "C0360714#ent", "<e2>", ",", "and", "terbinafine", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0360714", "name": "C0360714#ent", "pos": [30, 31]}}
{"token": ["The", "vanilloid", "receptor", "TRPV1", "or", "VR1", ")", "is", "a", "molecular", "integrator", "various", "C0030193#ent", "<e1>", "stimuli", ",", "including", "C0006931#ent", "<e2>", ",", "acid", ",", "and", "high", "temperature"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}, "relation": "may_be_prevented_by", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [17, 18]}}
{"token": ["Vanilloid", "receptors", "VR", ")", "integrate", "various", "C0030193#ent", "<e1>", "stimuli", ",", "e.g.", ",", "noxious", "heat", ",", "acidic", "pH", "C0006931#ent", "<e2>", ",", "and", "resiniferatoxin", "(", "RTX", ")", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [17, 18]}}
{"token": ["Oligonucleotide", "microarrays", "used", "to", "detect", "16", "C3887685#ent", "<e1>", "alleles", "that", "affect", "C3887685#ent", "<e1>", "activity", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [6, 7]}}
{"token": ["Polymorphism", "of", "C3887685#ent", "<e1>", "encoding", "for", "C3887685#ent", "<e1>", "determined", "genotypically", "for", "94", "controls", "and", "77", "lung", "cancer", "patients", "using", "a", "polymerase", "chain", "reaction-based", "application"], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [2, 3]}}
{"token": ["Some", "diseases", ",", "for", "example", "C0751937#ent", "<e1>", "to", "chemical", "mixtures", "are", "not", "included", "in", "the", "German", "list", "C0028797#ent", "<e2>"], "h": {"id": "C0751937", "name": "C0751937#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028797", "name": "C0028797#ent", "pos": [17, 18]}}
{"token": ["C0003308#ent", "<e1>", ",", "antibacterial", "and", "antitumoral", "properties", "of", "C0255013#ent", "<e2>", "were", "researched", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0255013", "name": "C0255013#ent", "pos": [8, 9]}}
{"token": ["The", "authors", "present", "two", "cases", "of", "pregnant", "women", "C0600503#ent", "<e1>", "one", "with", "C0020640#ent", "<e2>", "factor", "VII", "the", "second", "with", "chronic", "hepatitis"], "h": {"id": "C0600503", "name": "C0600503#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020640", "name": "C0020640#ent", "pos": [12, 13]}}
{"token": ["We", "compare", "the", "safety", "and", "effectiveness", "of", "twice-daily", "topical", "application", "during", "1", "week", "of", "0.6", "%", "and", "1", "%", "ajoene", "and", "1", "%", "C0771029#ent", "<e1>", "in", "the", "treatment", "of", "C0040259#ent", "<e2>"], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [29, 30]}}
{"token": ["This", "article", "gives", "a", "review", "of", "the", "effectiveness", "of", "the", "oral", "antifungal", "agents", "fluconazole", ",", "itraconazole", ",", "and", "C0771029#ent", "<e1>", "in", "the", "treatment", "of", "pityriasis", "versicolor", "tinea", "corporis/cruris", ",", "and", "C0040259#ent", "<e2>"], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [30, 31]}}
{"token": ["The", "expression", "of", "SGK1", "mRNA", ",", "C1422258#ent", "<e1>", "mRNA", "and", "C1822702#ent", "<e2>", "mRNA", "of", "kidney", "cortex", "measured", "by", "RT-PCR", ",", "and", "the", "cortical", "SGK1", "protein", "detected", "with", "Western", "blotting"], "h": {"id": "C1422258", "name": "C1422258#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1822702", "name": "C1822702#ent", "pos": [10, 11]}}
{"token": ["Mutation", "in", "the", "C1422258#ent", "<e1>", "Sgk3", ",", "also", "known", "as", "Sgkl", "or", "C1822702#ent", "<e2>", ")", "gene", "causes", "both", "defective", "hair", "follicle", "development", "and", "altered", "hair", "cycle", "mice", "."], "h": {"id": "C1422258", "name": "C1422258#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1822702", "name": "C1822702#ent", "pos": [12, 13]}}
{"token": ["Ivermectin", "is", "a", "common", "anthelmintic", "drug", "widely", "used", "in", "laboratory", "rodents", "treatment", "of", "C0086227#ent", "<e1>", "and", "mite", "C0030499#ent", "<e2>", "."], "h": {"id": "C0086227", "name": "C0086227#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [17, 18]}}
{"token": ["C0086227#ent", "<e1>", "rarely", "cause", "clinical", "disease", "but", "C0030499#ent", "<e2>", "can", "affect", "experimental", "results"], "h": {"id": "C0086227", "name": "C0086227#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [7, 8]}}
{"token": ["To", "reduce", "C0008281#ent", "<e1>", "sedating", "effect", "and", "increase", "its", "effectiveness", ",", "C0033798#ent", "<e2>", "was", "combined", "with", "chlorpheniramine", "to", "prevent", "motion", "sickness"], "h": {"id": "C0008281", "name": "C0008281#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [11, 12]}}
{"token": ["To", "conclude", ",", "lower", "erythrocyte", "Cu", ",", "C0669516#ent", "<e1>", "catalase", "activity", "young", "men", "with", "C0011854#ent", "<e2>", "at", "rest", "may", "contribute", "to", "increased", "oxidative", "stress"], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [14, 15]}}
{"token": ["Computed", "tomography", "used", "to", "exclude", "C0029408#ent", "<e1>", "of", "the", "zygapophyseal", "joints", "Baastrup", "'s", "disease", "(", "C0158248#ent", "<e2>", "and", "other", "sources", "of", "low", "back", "pain"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0158248", "name": "C0158248#ent", "pos": [15, 16]}}
{"token": ["Lymphocytes", "from", "the", "thoracic", "duct", "C3810054#ent", "<e1>", ")", "were", "incubated", "with", "interferon", "(", "C1415900#ent", "<e2>", ")", "prior", "to", "i.v", "."], "h": {"id": "C3810054", "name": "C3810054#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [13, 14]}}
{"token": ["A", "high", "content", "of", "C0013395#ent", "<e1>", "roughage", "in", "food", ",", "antacidity", "in", "conjunction", "with", "C0038354#ent", "<e2>", "are", "predisposing", "factors", "phytobezoar", "formation", "."], "h": {"id": "C0013395", "name": "C0013395#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0038354", "name": "C0038354#ent", "pos": [14, 15]}}
{"token": ["For", "purposes", "of", "evaluating", "this", "new", "method", ",", "C0011816#ent", "<e1>", ",", "alprenolol", ",", "and", "C0033497#ent", "<e2>", "were", "incubated", "separately", "for", "up", "to", "60", "minutes", "with", "rat", "and", "human", "hepatic", "microsomes"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [14, 15]}}
{"token": ["The", "three", "members", "of", "the", "C0206614#ent", "<e1>", "infect", "wildlife", "in", "ecosystems", "where", "domestic", "animals", "are", "rinderpest", ",", "C0949885#ent", "<e2>", "PPR", ")", "and", "canine", "distemper"], "h": {"id": "C0206614", "name": "C0206614#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0949885", "name": "C0949885#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "C0357126#ent", "<e1>", "can", "ameliorate", "drug-induced", "fibrosis", "endothelial", "damage", "by", "C0729502#ent", "<e2>"], "h": {"id": "C0357126", "name": "C0357126#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [12, 13]}}
{"token": ["The", "C1741214#ent", "<e1>", "(", "FK506-binding", "protein", "gene", ",", "SERT", "(", "serotonin", "transporter", "gene", "and", "C1135159#ent", "<e2>", "(", "catechol-o-methyltransferase", "gene", "mRNA", "expressions", "in", "the", "leukocytes", "were", "determined", "with", "hormonal", "data"], "h": {"id": "C1741214", "name": "C1741214#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1135159", "name": "C1135159#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "provide", "evidence", "that", "an", "OPR", "C1335597#ent", "<e1>", "rice", "chromosome", "8", "designated", "OsOPR7", ",", "encodes", "the", "C0027203#ent", "<e2>", "involved", "in", "the", "JA", "biosynthesis", "."], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["The", "incidence", "of", "MMR", "after", "Sch", "was", "less", "with", "C1420514#ent", "<e1>", "than", "with", "C0018549#ent", "<e2>", "alone", "or", "with", "C0018549#ent", "<e2>", "and", "C1420514#ent", "<e1>", "(", "P", "<", "0.025", ")", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420514", "name": "C1420514#ent", "pos": [9, 10]}}
{"token": ["The", "anaesthetic", "induction", "sequence", "consisted", "of", "intravenous", "sodium", "thiopentone", "(", "C1420514#ent", "<e1>", ")", "5", "mg.kg-1", "alone", ",", "C0018549#ent", "<e2>", "induction", "alone", "1", "-", "4", "%", ",", "or", "C0018549#ent", "<e2>", "followed", "by", "C1420514#ent", "<e1>", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420514", "name": "C1420514#ent", "pos": [10, 11]}}
{"token": ["Fifty", "two", "patients", "with", "C3714757#ent", "<e1>", "JCA", ")", "and", "22", "patients", "with", "arthritis", "of", "short", "duration", "C3887596#ent", "<e2>", "TA", ")", "were", "studied", "in", "a", "follow", "up", "investigation", "."], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887596", "name": "C3887596#ent", "pos": [16, 17]}}
{"token": ["Nonimmune", "hydrops", "fetalis", "becoming", "a", "predominant", "form", "of", "C0020305#ent", "<e1>", "to", "the", "declining", "incidence", "of", "C0455988#ent", "<e2>", "by", "Rh", "isoimmunization"], "h": {"id": "C0020305", "name": "C0020305#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [15, 16]}}
{"token": ["Two", "more", "unrelated", "patients", "with", "CDG-Ia", "who", "presented", "with", "C0020305#ent", "<e1>", "reported", "here", ",", "providing", "definite", "evidence", "that", "C0455988#ent", "<e2>", "be", "caused", "by", "CDG-Ia", "."], "h": {"id": "C0020305", "name": "C0020305#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [18, 19]}}
{"token": ["SNPs", "in", "C1420003#ent", "<e1>", "and", "MBL", "C0017337#ent", "<e2>", "showed", "significant", "associations", "with", "patients", "of", "allergic", "bronchopulmonary", "aspergillosis", "an", "Indian", "population"], "h": {"id": "C1420003", "name": "C1420003#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}}
{"token": ["The", "human", "SP-A", "locus", "consists", "of", "two", "functional", "SP-A", "genes", "SP-A1", "and", "C1420003#ent", "<e1>", ",", "with", "a", "number", "of", "alleles", "characterized", "for", "each", "C0017337#ent", "<e2>", "."], "h": {"id": "C1420003", "name": "C1420003#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "here", "two", "additional", "C1706649#ent", "<e1>", "in", "two", "Caucasoid", "recipient", "candidates", "for", "organ", "transplant", "a", "new", "C4290025#ent", "<e2>", "in", "a", "Caucasoid", "unrelated", "bone", "marrow", "donor", "from", "the", "German", "file"], "h": {"id": "C1706649", "name": "C1706649#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4290025", "name": "C4290025#ent", "pos": [17, 18]}}
{"token": ["Thyroid", "hormones", "increase", "the", "C4290025#ent", "<e1>", "and", "butyrate", "increases", "C1706649#ent", "<e2>", "and", "beta2AR", "but", "dramatically", "decreases", "C4290025#ent", "<e1>", "."], "h": {"id": "C1706649", "name": "C1706649#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4290025", "name": "C4290025#ent", "pos": [4, 5]}}
{"token": ["The", "C1706649#ent", "<e1>", "and", "beta2AR", "can", ",", "like", "the", "C4290025#ent", "<e2>", ",", "display", "atypical", "pharmacologies", "."], "h": {"id": "C1706649", "name": "C1706649#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4290025", "name": "C4290025#ent", "pos": [9, 10]}}
{"token": ["Only", "one", "patient", "had", "an", "abnormally", "low", "serum", "25-hydroxy-vitamin", "D", "result", ":", "this", "patient", "had", "a", "high", "level", "of", "urinary", "D-glucaric", "acid", "was", "receiving", "C0031412#ent", "<e1>", "for", "treatment", "of", "C0014547#ent", "<e2>", "."], "h": {"id": "C0031412", "name": "C0031412#ent", "pos": [24, 25]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [29, 30]}}
{"token": ["In", "a", "prospective", "study", "used", "C0031412#ent", "<e1>", "to", "treat", "13", "new", "patients", "with", "C0014547#ent", "<e2>", "(", "eight", "adults", "and", "five", "children", ")", "."], "h": {"id": "C0031412", "name": "C0031412#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [13, 14]}}
{"token": ["Both", "studies", "did", "not", "find", "evidence", "of", "fetal", "damage", "C0031412#ent", "<e1>", "was", "taken", "for", "indications", "other", "than", "C0014547#ent", "<e2>", "."], "h": {"id": "C0031412", "name": "C0031412#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [17, 18]}}
{"token": ["We", "present", "several", "C0007682#ent", "<e1>", "subarachnoid", "hemorrhage", "meningitis", ",", "leptomeningeal", "metastases", "acute", "infarction", "and", "severe", "C1306889#ent", "<e2>", "as", "moya-moya", "disease"], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1306889", "name": "C1306889#ent", "pos": [15, 16]}}
{"token": ["Listeria", "monocytogenes", "cause", "circling", "disease", "C0014060#ent", "<e1>", ",", "meningitis", ",", "septicemia", ",", "and", "C3668816#ent", "<e2>", "in", "dairy", "cattle"], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3668816", "name": "C3668816#ent", "pos": [13, 14]}}
{"token": ["The", "maedi-visna", "lentivirus", "MVV", ")", "induces", "C0014060#ent", "<e1>", ",", "interstitial", "pneumonia", "arthritis", "and", "C3668816#ent", "<e2>", "in", "sheep", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3668816", "name": "C3668816#ent", "pos": [13, 14]}}
{"token": ["So", "far", ",", "no", "clinical", "or", "experimental", "study", "demonstrated", "that", "any", "C0013227#ent", "<e1>", "has", "a", "beneficial", "effect", "(", "heparin", ",", "cortisone", ",", "C0086140#ent", "<e2>", ",", "etc", ".", ")"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [22, 23]}}
{"token": ["Oral", "administration", "this", "C0013227#ent", "<e1>", "prevents", "the", "long-term", "blood", "thickening", "effect", "of", "C0086140#ent", "<e2>", "and", "leads", "to", "a", "permanent", "improvement", "of", "microcirculation", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [12, 13]}}
{"token": ["C0220756#ent", "<e1>", "NPC", ")", "is", "a", "C0025517#ent", "<e2>", "is", "distinguished", "from", "Niemann-Pick", "disease", "its", "later", "onset", ",", "more", "insidious", "progression", ",", "variable", "visceromegaly", ",", "and", "abnormalities", "of", "intracellular", "cholesterol", "metabolism"], "h": {"id": "C0220756", "name": "C0220756#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [6, 7]}}
{"token": ["We", "evaluated", "the", "prevalence", "and", "progression", "of", "C0242380#ent", "<e1>", "patients", "with", "systemic", "lupus", "erythematosus", "any", "association", "between", "this", "C0018824#ent", "<e2>", "and", "their", "clinical", "and", "laboratory", "characteristics", "."], "h": {"id": "C0242380", "name": "C0242380#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [18, 19]}}
{"token": ["Mice", "with", "a", "C1706333#ent", "<e1>", "null", "mutation", "from", "recurrent", "bacterial", "infections", "impaired", "wound", "healing", "and", "C0037299#ent", "<e2>", "closely", "resembling", "human", "LAD1", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037299", "name": "C0037299#ent", "pos": [15, 16]}}
{"token": ["Next", ",", "both", "alleles", "of", "the", "C1412305#ent", "<e1>", "cloned", "from", "DNA", "of", "a", "patient", "bearing", "the", "C0398564#ent", "<e2>", "their", "nucleotide", "sequences", "."], "h": {"id": "C1412305", "name": "C1412305#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0398564", "name": "C0398564#ent", "pos": [16, 17]}}
{"token": ["There", "were", "30", "patients", "with", "acute", "hematogenous", "disease", "19", "osteomyelitis", ";", "three", "C0949690#ent", "<e1>", ";", "eight", "arthritis", ")", "and", "five", "with", "subacute", "or", "C0008707#ent", "<e2>"], "h": {"id": "C0949690", "name": "C0949690#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008707", "name": "C0008707#ent", "pos": [23, 24]}}
{"token": ["Idiopathic", "membranous", "glomerulonephritis", "immunoglobulin", "(", "Ig", ")", "A", "glomerulonephritis", ",", "Henoch-Sch\u00f6nlein", "nephritis", "membranoproliferative", "glomerulonephritis", "minimal", "change", "glomerulonephritis", "postinfectious", "glomerulonephritis", "lupus", "nephritis", "amyloidosis", ",", "focal", "segmental", "glomerulosclerosis", "and", "rarely", "C0403416#ent", "<e1>", "all", "occur", "with", "C1442864#ent", "<e2>"], "h": {"id": "C0403416", "name": "C0403416#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [33, 34]}}
{"token": ["Cutaneous", "mucinoses", "also", "called", "C0263390#ent", "<e1>", "are", "a", "group", "of", "C0012634#ent", "<e2>", "characterized", "by", "mucin", "deposit", "on", "the", "skin", "."], "h": {"id": "C0263390", "name": "C0263390#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["C0263390#ent", "<e1>", "(", "SM", ")", "may", "be", "considered", "as", "a", "possible", "C0012634#ent", "<e2>", "the", "differential", "diagnosis", "scleroderma", "."], "h": {"id": "C0263390", "name": "C0263390#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["Only", "two", "wide-spectrum", "serine/threonine", "kinase", "inhibitors", "H-7", "and", "C0214900#ent", "<e1>", "could", "prevent", "the", "down-regulation", "of", "alpha1(I", ")", "C0009325#ent", "<e2>", "mRNA", "levels", "in", "cells", "exposed", "to", "collagen", "."], "h": {"id": "C0214900", "name": "C0214900#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [17, 18]}}
{"token": ["In", "monolayer", "C0214900#ent", "<e1>", "slightly", "down-regulated", "collagen", "gene", "expression", ",", "indicating", "that", "inside", "C0009325#ent", "<e2>", "it", "affected", "integrin", "signaling", "rather", "than", "having", "a", "direct", "stimulatory", "effect", "on", "C0009325#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0214900", "name": "C0214900#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [13, 14]}}
{"token": ["C0017628#ent", "<e1>", ",", "the", "most", "common", "oral", "therapeutic", "agent", "C0011860#ent", "<e2>", "is", "associated", "with", "release", "of", "the", "autocrine", "insulin", "secretion", "inhibitor", ",", "NPY", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [9, 10]}}
{"token": ["Although", "destructive", "C0005940#ent", "<e1>", "a", "well-known", "complication", "of", "tertiary", "syphilis", "osteitis", "or", "C0029443#ent", "<e2>", "are", "not", "commonly", "recognized", "as", "complications", "of", "early", "(", "primary", "or", "secondary)", "syphillis"], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [12, 13]}}
{"token": ["Expression", "of", "the", "C1335808#ent", "<e1>", "ligand", "by", "endothelium", "was", "optimally", "induced", "by", "C2697656#ent", "<e2>", "and", "the", "proinflammatory", "cytokines", "TNF-alpha", "and", "IL-1", "beta", "whereas", "IFN-gamma", "and", "IL-4", "induced", "lower", "levels", "of", "expression", "."], "h": {"id": "C1335808", "name": "C1335808#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [12, 13]}}
{"token": ["Considering", "all", "HIV-positive", "patients", "(", "including", "LD", ")", ",", "mtDNA", "content", "showed", "a", "significant", ",", "positive", "correlation", "with", "C0151718#ent", "<e1>", "but", "not", "with", "C0020557#ent", "<e2>", "and", "glycaemia", "."], "h": {"id": "C0151718", "name": "C0151718#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [23, 24]}}
{"token": ["They", "demonstrate", "mainly", "a", "reduction", "in", "triglyceridaemia", "and", "only", "a", "relatively", "slight", "decrease", "in", "C0151718#ent", "<e1>", "mostly", "in", "(", "slightly", ")", "C0020557#ent", "<e2>", "conditions", "."], "h": {"id": "C0151718", "name": "C0151718#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [21, 22]}}
{"token": ["C0151718#ent", "<e1>", "is", "very", "frequent", ",", "and", "C0020557#ent", "<e2>", "seems", "to", "be", "associated", "with", "severe", "malaria", "."], "h": {"id": "C0151718", "name": "C0151718#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [7, 8]}}
{"token": ["Overexpression", "of", "the", "C1853479#ent", "<e1>", "the", "functional", "defects", "of", "mtHsp70", "in", "C1412499#ent", "<e2>", "-", "3", "cells", "and", "a", "fusion", "protein", "the", "C1853479#ent", "<e1>", "interacts", "with", "purified", "mtHsp70", "."], "h": {"id": "C1412499", "name": "C1412499#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1853479", "name": "C1853479#ent", "pos": [3, 4]}}
{"token": ["This", "activity", "was", "specifically", "increased", "four-fold", "upon", "addition", "of", "beta-naphthoflavone", "into", "culture", "medium", "not", "by", "rifampicine", "or", "C0009002#ent", "<e1>", "and", "was", "related", "to", "a", "biosynthesis", "of", "C1567723#ent", "<e2>", "UGT1*6", "."], "h": {"id": "C0009002", "name": "C0009002#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1567723", "name": "C1567723#ent", "pos": [26, 27]}}
{"token": ["Thus", ",", "the", "use", "of", "PEFV", "curve", "measurement", "did", "not", "facilitate", "the", "detection", "of", "individual", "C0004096#ent", "<e1>", "responses", "to", "C0029193#ent", "<e2>"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0029193", "name": "C0029193#ent", "pos": [19, 20]}}
{"token": ["Responses", "to", "inhaled", "metaproterenol", "much", "larger", "on", "PEFV", "than", "MEFV", "curves", ";", "nevertheless", ",", "differences", "between", "normal", "and", "C0004096#ent", "<e1>", "subjects", "in", "C0029193#ent", "<e2>", "responsiveness", "were", "less", "using", "PEFV", "curves", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0029193", "name": "C0029193#ent", "pos": [22, 23]}}
{"token": ["The", "C0669365#ent", "<e1>", "synthesis", "of", "C0015278#ent", "<e2>", "was", "repressed", "by", "the", "addition", "of", "glucosamine", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015278", "name": "C0015278#ent", "pos": [5, 6]}}
{"token": ["It", "prevented", "derepression", "of", "isocitrate", "lyase", "fructose-1,6-diphosphatase", "and", "C0015278#ent", "<e1>", "in", "a", "C0669365#ent", "<e2>", "but", "glucose", "sensitive", "C0015278#ent", "<e1>", "mutant", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015278", "name": "C0015278#ent", "pos": [8, 9]}}
{"token": ["Mutations", "resulting", "in", "C0669365#ent", "<e1>", "production", "of", "C0015278#ent", "<e2>", "have", "been", "identified", "at", "each", "of", "the", "five", "MAL", "loci", "of", "Saccharomyces", "yeasts"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015278", "name": "C0015278#ent", "pos": [7, 8]}}
{"token": ["Western", "blot", "analysis", "that", "recombinant", "C1413775#ent", "<e1>", "be", "cross-linked", "to", "a", "variety", "of", "C0086376#ent", "<e2>", "extracted", "from", "stratum", "corneum"], "h": {"id": "C1413775", "name": "C1413775#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["In", "addition", "to", "the", "expected", "C1334103#ent", "<e1>", "component", ",", "morphosyntactic", "violations", "in", "C1418789#ent", "<e2>", "but", "not", "L1", "led", "to", "an", "enhanced", "N400", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418789", "name": "C1418789#ent", "pos": [12, 13]}}
{"token": ["Both", "mutants", "were", "found", "to", "possess", "C0007034#ent", "<e1>", "which", "are", "below", "C2987364#ent", "<e2>", "levels", ",", "and", "in", "the", "P-N", "mutant", "this", "activity", "appears", "to", "be", "unstable", "."], "h": {"id": "C0007034", "name": "C0007034#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [11, 12]}}
{"token": ["It", "is", "intriguing", ",", "therefore", ",", "that", "C2984561#ent", "<e1>", "were", "normalized", "by", "transsphenoidal", "C1420002#ent", "<e2>", "."], "h": {"id": "C2984561", "name": "C2984561#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "C1418975#ent", "<e1>", "indispensable", "for", "in", "vivo", "degradation", "of", "galactosylceramide", "by", "C1414946#ent", "<e2>", "."], "h": {"id": "C1418975", "name": "C1418975#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414946", "name": "C1414946#ent", "pos": [12, 13]}}
{"token": ["In", "C0724441#ent", "<e1>", "full", "generalization", "to", "DPAT", ",", "C0060454#ent", "<e2>", "and", "tandospirone", "was", "observed", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0060454", "name": "C0060454#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "show", "that", "when", "C0010592#ent", "<e1>", "is", "used", "as", "the", "primary", "C0022252#ent", "<e2>", ",", "further", "proliferation", "can", "be", "inhibited", "by", "rapamycin", ",", "mycophenolic", "acid", "or", "suramin", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022252", "name": "C0022252#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "diffusion", "abnormalities", "the", "posterior", "cingulate", "fiber", "tracts", "(", "C1968832#ent", "<e1>", ")", "in", "patients", "with", "Alzheimer's", "disease", "AD", ")", "by", "diffusion", "tensor", "tractography", "C0012789#ent", "<e2>", ")", "."], "h": {"id": "C1968832", "name": "C1968832#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [30, 31]}}
{"token": ["C1419805#ent", "<e1>", "immunoreactive", "pinealocytes", "were", "shown", "to", "respond", "to", "C3887648#ent", "<e2>", "stimulation", "with", "an", "elevation", "of", "the", "intracellular", "free", "calcium", "concentration", "[Ca2+]i", ")", "."], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [9, 10]}}
{"token": ["C0030817#ent", "<e1>", "may", "favorably", "influence", "the", "course", "of", "primary", "C0023892#ent", "<e2>", "its", "immunologic", "action", "addition", "to", "its", "copper-chelating", "action", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0023892", "name": "C0023892#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "in", "all", "cell", "lines", "tested", ",", "a", "chronic", "exposure", "of", "cells", "to", "C1423607#ent", "<e1>", "abrogates", "C0388638#ent", "<e2>", "activation", "by", "either", "phorbol", "esters", "C1423607#ent", "<e1>", "itself", "with", "no", "effect", "total", "cellular", "C0388638#ent", "<e2>", "levels", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1423607", "name": "C1423607#ent", "pos": [14, 15]}}
{"token": ["The", "relationship", "of", "C0388638#ent", "<e1>", "to", "the", "anticancer", "properties", "C1423607#ent", "<e2>", "may", "be", "clinically", "relevant", "to", "drug", "actions"], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423607", "name": "C1423607#ent", "pos": [9, 10]}}
{"token": ["C0388638#ent", "<e1>", "activity", "induced", "by", "C1423607#ent", "<e2>", "was", "totally", "inhibited", "by", "cellular", "pretreatment", "phorbol", "dibutyrate", "and", "59", "%", "diminished", "by", "pretreatment", "of", "cells", "with", "staurosporine", ",", "a", "protein", "kinase", "C", "PKC", ")", "inhibitor", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423607", "name": "C1423607#ent", "pos": [5, 6]}}
{"token": ["(+)Catechin", ",", "(", "-", ")", "epicatechin", "and", "C0006507#ent", "<e1>", "failed", "to", "inhibit", "or", "only", "slightly", "inhibited", "TPA-caused", "C1422630#ent", "<e2>", "induction", "."], "h": {"id": "C0006507", "name": "C0006507#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422630", "name": "C1422630#ent", "pos": [17, 18]}}
{"token": ["The", "synthesis", "and", "study", "of", "dehydrobenzoannulene", "(DBA)-dimethyldihydropyrene", "(", "C1420740#ent", "<e1>", ")", "hybrids", "as", "models", "for", "the", "investigation", "of", "C0772162#ent", "<e2>", "in", "weakly", "diatropic", "systems", "is", "reported", "."], "h": {"id": "C1420740", "name": "C1420740#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0772162", "name": "C0772162#ent", "pos": [18, 19]}}
{"token": ["Amino", "acid", "analysis", "N-terminal", "sequence", "analysis", "that", "the", "bacterial", "C1420740#ent", "<e1>", "from", "cyanobacteria", "are", "unique", ",", "having", "many", "C0772162#ent", "<e2>", "and", "aliphatic", "residues", "and", "no", "apparent", "association", "of", "hydroxylated", "or", "basic", "amino", "acids", "cysteines", "."], "h": {"id": "C1420740", "name": "C1420740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0772162", "name": "C0772162#ent", "pos": [18, 19]}}
{"token": ["If", "these", "avoidance", "procedures", "together", "with", "oral", "and", "ocular", "antihistamines", "C0042398#ent", "<e1>", ",", "do", "not", "provide", "relief", "of", "symptoms", ",", "intranasal", "corticosteroids", "C0012694#ent", "<e2>", "may", "be", "prescribed", "."], "h": {"id": "C0042398", "name": "C0042398#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [22, 23]}}
{"token": ["In", "the", "absence", "of", "extracellular", "calcium", ",", "both", "groups", "of", "C2936568#ent", "<e1>", "tested", "with", "C1705556#ent", "<e2>", "and", "2MeSATP", ")", "were", "equally", "able", "to", "release", "calcium", "from", "intracellular", "stores", "."], "h": {"id": "C2936568", "name": "C2936568#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [14, 15]}}
{"token": ["C1517495#ent", "<e1>", "that", "at", "least", "part", "of", "the", "observed", "C1826403#ent", "<e2>", "mRNA", "heterogeneity", "is", "caused", "by", "alternative", "splicing", "resulting", "in", "exon", "skipping", "."], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826403", "name": "C1826403#ent", "pos": [9, 10]}}
{"token": ["The", "increased", "food", "intake", "induced", "by", "C1367710#ent", "<e1>", "was", "also", "reversed", "by", "C0733398#ent", "<e2>", ",", "an", "alpha-adrenergic", "antagonist"], "h": {"id": "C1367710", "name": "C1367710#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0733398", "name": "C0733398#ent", "pos": [12, 13]}}
{"token": ["The", "idiopathic", "inflammatory", "myopathies", "IIM", ")", "are", "a", "heterogeneous", "group", "C0027868#ent", "<e1>", "into", "polymyositis", "(", "PM", ")", ",", "C0751713#ent", "<e2>", "sIBM", ")", "and", "dermatomyositis", "(", "DM", ")", "."], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751713", "name": "C0751713#ent", "pos": [18, 19]}}
{"token": ["Adhesion", "of", "activated", "platelets", "to", "C1336937#ent", "<e1>", "substrate", "is", "dependent", "upon", "the", "presence", "of", "divalent", "cations", "the", "amount", "of", "C1336937#ent", "<e1>", ",", "and", "the", "C0720099#ent", "<e1>", "of", "adhesion", "assay"], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [24, 25]}}
{"token": ["We", "think", "that", "elective", "cholecystectomy", "a", "safe", "therapeutic", "procedure", "C2609268#ent", "<e1>", "which", "also", "considers", "the", "association", "of", "C0856727#ent", "<e2>", "gallbladder", "carcinoma"], "h": {"id": "C2609268", "name": "C2609268#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [17, 18]}}
{"token": ["Nineteen", "patients", "with", "different", "clinical", "subsets", "of", "C0024140#ent", "<e1>", "LE", ")", "were", "treated", "with", "C0035339#ent", "<e2>"], "h": {"id": "C0024140", "name": "C0024140#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [14, 15]}}
{"token": ["The", "results", "confirm", "reports", "that", "the", "presence", "of", "both", "Ca2", "+", "and", "C1417500#ent", "<e1>", "+", "in", "fusion", "medium", "pretreatment", "of", "mixed", "cells", "C0030940#ent", "<e2>", "improve", "hybridoma", "yield", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [22, 23]}}
{"token": ["To", "learn", "whether", "or", "not", "C1417500#ent", "<e1>", "+", "and", "Na+", "react", "with", "different", "receptor", "sites", "a", "C0030940#ent", "<e2>", "topically", "applied", "to", "the", "tongue", "dorsum"], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [16, 17]}}
{"token": ["The", "mutated", "C0165193#ent", "<e1>", "was", "expressed", "at", "10-fold", "higher", "levels", "than", "wild-type", "C0165193#ent", "<e1>", ",", "but", "it", "exhibited", "no", "C1705556#ent", "<e1>", "binding", "."], "h": {"id": "C0165193", "name": "C0165193#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [19, 20]}}
{"token": ["We", "also", "analysed", "the", "effects", "of", "C0246694#ent", "<e1>", "on", "the", "activation", "of", "NF-kappaB", "and", "C0087140#ent", "<e2>", "and", "on", "the", "IkappaB", "molecule", "."], "h": {"id": "C0246694", "name": "C0246694#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [14, 15]}}
{"token": ["Interleukin-1", "beta", "IL-1", "beta", "enhanced", "C0751039#ent", "<e1>", "expression", "(", "both", "mRNA", "and", "enzyme", "activity", "similar", "to", "C1420314#ent", "<e2>", ",", "while", "tumor", "necrosis", "factor-alpha", "TNF-alpha", ")", "was", "less", "effective", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [16, 17]}}
{"token": ["Importantly", ",", "C1420314#ent", "<e1>", "had", "no", "apparent", "effect", "on", "the", "CsA-induced", "suppression", "of", "interleukin-2", "mRNA", "expression", "in", "vitro", "thereby", "indicating", "that", "the", "immunosuppressive", "potential", "of", "C0751039#ent", "<e2>", "was", "not", "affected", "by", "C1420314#ent", "<e1>", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [2, 3]}}
{"token": ["Our", "data", "suggest", "that", "the", "effect", "of", "C0751039#ent", "<e1>", "on", "podocytes", "may", "contribute", "to", "the", "glomerular", "damage", "that", "C1420314#ent", "<e2>", "could", "provide", "protection", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [18, 19]}}
{"token": ["Similarly", ",", "the", "phorbol", "ester", ",", "potentially", "stimulating", "C0031686#ent", "<e1>", "staurosporine", ",", "an", "inhibitor", "of", "C1414387#ent", "<e2>", "enhanced", "adhesion", "to", "VCAM-1", "as", "has", "previously", "been", "shown", "for", "ICAM-1", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [15, 16]}}
{"token": ["C0031686#ent", "<e1>", "PPs", ")", "can", "be", "classified", "as", "C1414387#ent", "<e2>", "and", "tyrosine", "specific", "phosphatases", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [8, 9]}}
{"token": ["However", ",", "chlorthalidone", "and", "C0065374#ent", "<e1>", "were", "more", "effective", "at", "preventing", "C0018801#ent", "<e2>", "whereas", "amlodipine", "and", "chlorthalidone", "were", "more", "effective", "than", "C0065374#ent", "<e1>", "at", "preventing", "stroke", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [4, 5]}}
{"token": ["To", "determine", "the", "sequence", "of", "critical", "cardiovascular", "events", "the", "progression", "of", "C0018801#ent", "<e1>", "and", "whether", "aetiology", "or", "high-dose", "vs", "low-dose", "C0065374#ent", "<e2>", "affected", "these", "pathways", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [20, 21]}}
{"token": ["PDE4C-containing", "cosmids", "also", "contained", "the", "genes", "for", "the", "growth", "regulatory", "transcription", "factor", "C0812312#ent", "<e1>", ",", "and", "the", "C1332111#ent", "<e2>", "RAB3A", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332111", "name": "C1332111#ent", "pos": [17, 18]}}
{"token": ["The", "observation", "that", "C0030438#ent", "<e1>", "(", "rather", "than", "acetic", "acid", "is", "extruded", "during", "anaerobic", "C1420797#ent", "<e2>", "synthesis", "is", "in", "full", "accord", "with", "the", "structure", "of", "factor", "IV", "a", "new", "intermediate", "on", "the", "pathway", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420797", "name": "C1420797#ent", "pos": [14, 15]}}
{"token": ["IFNgamma", "dysregulation", "in", "C0085077#ent", "<e1>", "salivary", "gland", "attribute", "to", "the", "decreased", "production", "of", "C1366557#ent", "<e2>", "from", "salivary", "epithelial", "cells", "some", "patients", "."], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366557", "name": "C1366557#ent", "pos": [13, 14]}}
{"token": ["Experiments", "were", "performed", "to", "test", "the", "hypothesis", "that", "subarachnoid", "hemorrhage", "C1825840#ent", "<e1>", ")", "causes", "functionally", "relevant", "perturbations", "of", "C0033551#ent", "<e2>", "cerebral", "arteries"], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [18, 19]}}
{"token": ["To", "describe", "the", "phenotype", "in", "3", "families", "with", "dominantly", "inherited", "cone", "and", "C4085590#ent", "<e1>", "mutations", "in", "guanylate", "cyclase", "activator", "1A", "GUCA1A", ")", ",", "the", "gene-encoding", "guanylate", "cyclase", "activator", "protein-1", "C1420888#ent", "<e2>", ")", "."], "h": {"id": "C4085590", "name": "C4085590#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420888", "name": "C1420888#ent", "pos": [29, 30]}}
{"token": ["Pyrogallol", ",", "a", "C0595267#ent", "<e1>", "blocks", "the", "action", "of", "arsenite-", "and", "monomethylarsonic", "methyltransferase", "C3541394#ent", "<e2>", ",", "suggesting", "a", "close", "structural", "relationship", "between", "the", "active", "sites", "the", "different", "C3541394#ent", "<e2>", "."], "h": {"id": "C0595267", "name": "C0595267#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["The", "other", "two", "groups", "are", "C1512488#ent", "<e1>", "to", "the", "nonspecific", "cross-reacting", "antigen", "NCA", ")", "and", "C1413306#ent", "<e2>", "BGP", ")", ",", "both", "of", "which", "are", "members", "of", "the", "carcinoembryonic", "antigen", "CEA", ")", "family", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413306", "name": "C1413306#ent", "pos": [15, 16]}}
{"token": ["To", "study", "the", "C1538120#ent", "<e1>", "fusion", "mediated", "by", "syncytin", ",", "we", "tested", "whether", "C1704663#ent", "<e2>", "is", "involved", "in", "this", "process", "by", "regulating", "syncytin", "gene", "expression", "."], "h": {"id": "C1538120", "name": "C1538120#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704663", "name": "C1704663#ent", "pos": [13, 14]}}
{"token": ["Kindling", "increased", "the", "density", "of", "C0047123#ent", "<e1>", ",", "glycine", ",", "and", "C1842402#ent", "<e2>", "binding", "sites", "hippocampal", "membranes", "by", "47", "%", ",", "42", "%", ",", "and", "25", "%", ",", "respectively", "."], "h": {"id": "C0047123", "name": "C0047123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1842402", "name": "C1842402#ent", "pos": [11, 12]}}
{"token": ["In", "this", "pilot", "study", "we", "assessed", "the", "fitness", "to", "drive", "of", "stable", "individuals", "with", "cirrhosis", "and", "clinical", "evidence", "C0020541#ent", "<e1>", "portal-systemic", "shunting", "no", "prior", "history", "of", "C0019151#ent", "<e2>"], "h": {"id": "C0020541", "name": "C0020541#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [26, 27]}}
{"token": ["The", "C0022541#ent", "<e1>", "post-menopausal", "females", "to", "represent", "a", "separate", ",", "previously", "not", "described", "C0039082#ent", "<e2>", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [13, 14]}}
{"token": ["The", "twins", "reinforce", "the", "view", "that", "C0022541#ent", "<e1>", "is", "a", "specific", "C0039082#ent", "<e2>", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [11, 12]}}
{"token": ["From", "these", "results", ",", "we", "propose", "that", "wheat", "DNA", "polymerase", "A", "correspond", "to", "a", "DNA", "polymerase", "alpha", "C0012892#ent", "<e1>", "CII", "could", "correspond", "to", "the", "C1414071#ent", "<e2>", "and", "DNA", "polymerase", "CI", "could", "correspond", "to", "DNA", "polymerase", "beta"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414071", "name": "C1414071#ent", "pos": [24, 25]}}
{"token": ["The", "C1335796#ent", "<e1>", "antagonist", "CGRP-(8", "-", "37)-peptide", "inhibited", "C1382029#ent", "<e2>", "stimulated", "by", "EC50", "concentrations", "of", "either", "amylin", "or", "C1335796#ent", "<e1>", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335796", "name": "C1335796#ent", "pos": [1, 2]}}
{"token": ["Amylin", "activated", "C1382029#ent", "<e1>", "apparently", "simple", "Michaelien", "kinetics", "whereas", "C1335796#ent", "<e2>", "elicited", "activation", "by", "kinetics", "indicative", "of", "apparent", "negative", "co-operativity", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335796", "name": "C1335796#ent", "pos": [9, 10]}}
{"token": ["Biotinylated", "G(i)(alpha)(1", ")", ",", "modified", "at", "either", "the", "N", "or", "C", "terminus", ",", "serves", "as", "a", "C1721278#ent", "<e1>", "target", "for", "mRNA-displayed", "GPR", "C0030956#ent", "<e2>", "."], "h": {"id": "C1721278", "name": "C1721278#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [22, 23]}}
{"token": ["To", "determine", "which", "amino", "acids", "the", "recently", "cloned", "seven-transmembrane", "domain-type", "human", "galanin", "receptor", "are", "involved", "in", "the", "C1721278#ent", "<e1>", "the", "endogenous", "C0030956#ent", "<e2>", "ligand", ",", "we", "performed", "a", "mutagenesis", "study", "."], "h": {"id": "C1721278", "name": "C1721278#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [21, 22]}}
{"token": ["This", "association", "was", "most", "apparent", "when", "studying", "C0026857#ent", "<e1>", "impaired", "working", "capacity", "men", "and", "C0012634#ent", "<e2>", "of", "the", "circulatory", "organs", "impaired", "hearing", "for", "women", "."], "h": {"id": "C0026857", "name": "C0026857#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["We", "have", "initially", "identified", "a", "mutation", "in", "C1412367#ent", "<e1>", "as", "a", "causative", "for", "a", "juvenile", "autosomal", "recessive", "form", "C1862939#ent", "<e2>", "ALS", ")", ",", "termed", "C1412367#ent", "<e1>", "(", "OMIM", "205100", ")", "."], "h": {"id": "C1412367", "name": "C1412367#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1862939", "name": "C1862939#ent", "pos": [18, 19]}}
{"token": ["C1412367#ent", "<e1>", "is", "the", "gene", "mutated", "a", "recessive", "juvenile", "of", "C1862939#ent", "<e2>", "C1412367#ent", "<e1>", ")", "."], "h": {"id": "C1412367", "name": "C1412367#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1862939", "name": "C1862939#ent", "pos": [10, 11]}}
{"token": ["C1412367#ent", "<e1>", "is", "the", "gene", "product", "mutated", "in", "three", "juvenile-onset", "neurodegenerative", "disorders", "C1862939#ent", "<e2>", "ALS2", ")", "."], "h": {"id": "C1412367", "name": "C1412367#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1862939", "name": "C1862939#ent", "pos": [12, 13]}}
{"token": ["Two", "of", "these", "lipophilic", "beta", "blockers", "C0025859#ent", "<e1>", "and", "propranolol", ",", "have", "also", "been", "shown", "to", "prevent", "C0042510#ent", "<e2>", "after", "MI", "in", "clinical", "studies"], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [17, 18]}}
{"token": ["But", ",", "in", "this", "report", ",", "the", "effect", "of", "C0012010#ent", "<e1>", "in", "the", "treatment", "of", "infantile", "spasms", "C0014544#ent", "<e2>", "reported", "."], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [17, 18]}}
{"token": ["We", "report", "here", "the", "activation", "by", "EGF", "of", "a", "C1413746#ent", "<e1>", "a", "cell-free", "system", "activation", "of", "DNA", "binding", "ligand", ",", "receptor", ",", "C2744579#ent", "<e2>", "and", "phosphotyrosine-SH2", "interactions", "."], "h": {"id": "C1413746", "name": "C1413746#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [22, 23]}}
{"token": ["A", "coupled", "spectroscopic", "ATPase", "assay", "was", "used", "to", "investigate", "the", "interaction", "of", "C1413746#ent", "<e1>", "with", "RNA", "and", "C2744579#ent", "<e2>", "."], "h": {"id": "C1413746", "name": "C1413746#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [17, 18]}}
{"token": ["In", "Jurkat", "T-cells", "deficient", "for", "C2698408#ent", "<e1>", "IKKgamma", ",", "also", "known", "as", "C1416380#ent", "<e2>", ")", ",", "an", "essential", "component", "of", "the", "NF-kappaB-inducing-IKK", "complex", ",", "induction", "of", "TRAF4", "was", "completely", "inhibited", "."], "h": {"id": "C2698408", "name": "C2698408#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416380", "name": "C1416380#ent", "pos": [12, 13]}}
{"token": ["It", "is", "known", "that", "the", "angiotensin", "receptor", "blockers", "C0074722#ent", "<e1>", ")", "have", "organ", "protective", "effects", "patients", "with", "heart", "failure", "C1565662#ent", "<e2>"], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [19, 20]}}
{"token": ["Angiotensin-converting", "enzyme", "inhibitors", "ACEIs", ")", "and", "angiotensin-receptor", "blockers", "C0074722#ent", "<e1>", ")", "reduce", "urinary", "protein", "excretion", "and", "slow", "progression", "C1565662#ent", "<e2>", "independent", "of", "blood", "pressure", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [18, 19]}}
{"token": ["Therefore", ",", "C0087140#ent", "<e1>", "is", "a", "key", "regulator", "of", "c-FLIP(L", ")", ",", "and", "activation", "of", "C0087140#ent", "<e1>", "determines", "whether", "a", "cancer", "cell", "undergo", "cell", "death", "C1336646#ent", "<e1>", "treatment", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336646", "name": "C1336646#ent", "pos": [25, 26]}}
{"token": ["C0356588#ent", "<e1>", "is", "more", "effective", "than", "C0086268#ent", "<e2>", "in", "the", "treatment", "of", "hypercalcemia", "of", "malignancy", "and", "can", "be", "administered", "as", "a", "single", "i.v", "."], "h": {"id": "C0356588", "name": "C0356588#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086268", "name": "C0086268#ent", "pos": [6, 7]}}
{"token": ["We", "report", "the", "case", "of", "a", "patient", "who", "developed", "C0023895#ent", "<e1>", "and", "rhabdomyolysis", "accompanied", "by", "C3854173#ent", "<e2>", "4", "weeks", "of", "lovastatin", "monotherapy", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [15, 16]}}
{"token": ["Meanwhile", ",", "caponization", "increased", "nicotinamide", "adenine", "dinucleotide", "phosphate", "C0030016#ent", "<e1>", "(", "C0024544#ent", "<e2>", ")", "activity", "and", "C0024544#ent", "<e2>", "mRNA", "content", "(", "P", "=", "0.09", ")", "simultaneously", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "the", "SLDH", "is", "a", "novel", "kind", "of", "C0030016#ent", "<e1>", "distinct", "from", "C0024544#ent", "<e2>", "previously", "reported", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [15, 16]}}
{"token": ["The", "course", "of", "second-trimester", "abortions", "with", "the", "intention", "to", "use", "C0044923#ent", "<e1>", "as", "the", "only", "C0000784#ent", "<e2>", "is", "described", "."], "h": {"id": "C0044923", "name": "C0044923#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000784", "name": "C0000784#ent", "pos": [15, 16]}}
{"token": ["We", "thus", "concluded", "that", "misoprostol", "was", "at", "least", "as", "effective", "as", "C0044923#ent", "<e1>", "as", "an", "C0000784#ent", "<e2>", "for", "intrauterine", "death", "second", "trimester", "pregnancy"], "h": {"id": "C0044923", "name": "C0044923#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0000784", "name": "C0000784#ent", "pos": [15, 16]}}
{"token": ["This", "prospective", ",", "randomized", "study", "the", "efficacy", "of", "intravaginal", "misoprostol", "Cytotec", ")", "and", "C0044923#ent", "<e1>", "(", "Cervagem", ")", "as", "an", "C0000784#ent", "<e2>", "for", "intrauterine", "deaths", "second", "trimester", "pregnancy"], "h": {"id": "C0044923", "name": "C0044923#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0000784", "name": "C0000784#ent", "pos": [20, 21]}}
{"token": ["The", "diagnosis", "of", "penicilliosis", "marneffei", "can", "be", "difficult", "because", "the", "clinical", "manifestations", "those", "of", "tuberculosis", ",", "C0019655#ent", "<e1>", ",", "and", "other", "C0026946#ent", "<e2>"], "h": {"id": "C0019655", "name": "C0019655#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [21, 22]}}
{"token": ["Among", "the", "TCA", "cycle", "C1453024#ent", "<e1>", "fumarate", "reductase", "fumarase", "(", "malate", "dehydration", ",", "malate", "dehydrogenase", "malate", "oxidation", "oxaloacetate", "reduction", "and", "C0065558#ent", "<e2>", "malate", "decarboxylation", "were", "detected", "in", "the", "mitochondrial", "fraction"], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0065558", "name": "C0065558#ent", "pos": [20, 21]}}
{"token": ["Washed", "cell", "suspensions", "from", "these", "carbon-limited", "cultures", "rapidly", "oxidized", "added", "succinate", "to", "extracellular", "pyruvate", "through", "the", "sequential", "action", "of", "C1453024#ent", "<e1>", "fumarase", ",", "and", "C0065558#ent", "<e2>"], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0065558", "name": "C0065558#ent", "pos": [24, 25]}}
{"token": ["One", "adult", "level", "test", ",", "the", "Reading", "the", "Mind", "in", "the", "Eyes", "test", "shown", "that", "AS", "and", "C2674616#ent", "<e1>", "subjects", "have", "measurable", "deficits", "in", "the", "ability", "to", "make", "C1826706#ent", "<e2>", "inferences", "."], "h": {"id": "C2674616", "name": "C2674616#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1826706", "name": "C1826706#ent", "pos": [28, 29]}}
{"token": ["AP-A", "and", "C4083142#ent", "<e1>", "have", "been", "sequenced", "and", "C1421425#ent", "<e2>", "partially", "sequenced", "."], "h": {"id": "C4083142", "name": "C4083142#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421425", "name": "C1421425#ent", "pos": [8, 9]}}
{"token": ["Incubation", "of", "Jurkat", "cells", "C0912779#ent", "<e1>", "(", "TBB", ")", ",", "a", "specific", "inhibitor", "of", "C0010536#ent", "<e2>", "CK2", ",", "induces", "dose-and", "time-dependent", "apoptosis", "judged", "by", "several", "criteria", "."], "h": {"id": "C0912779", "name": "C0912779#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [14, 15]}}
{"token": ["I", "classified", "envelopes", "of", "phrenic", "nerve", "activity", "as", "eupneic", "breaths", ",", "or", "C0425449#ent", "<e1>", "based", "on", "the", "time-domain", "features", "of", "C2926735#ent", "<e2>", ",", "shape", ",", "and", "amplitude", "."], "h": {"id": "C0425449", "name": "C0425449#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [20, 21]}}
{"token": ["Using", "naive", "T", "cells", "T", "lymphoblasts", "MSK1/2-knockout", "mice", ",", "it", "was", "found", "that", "C1420279#ent", "<e1>", "was", "the", "C0031727#ent", "<e2>", "responsible", "for", "phosphorylation", "of", "the", "transcription", "factor", "CREB", "in", "response", "to", "TCR", "stimulation", "."], "h": {"id": "C1420279", "name": "C1420279#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["C1420279#ent", "<e1>", ",", "myocardial", "SNF1-like", "kinase", "was", "originally", "isolated", "in", "a", "screen", "for", "C0031727#ent", "<e2>", "expressed", "during", "early", "cardiogenesis", "in", "the", "mouse", "."], "h": {"id": "C1420279", "name": "C1420279#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["When", "[methyl-3H]methylmalonyl-CoA", "was", "incubated", "with", "highly", "purified", "C1417504#ent", "<e1>", "tritium", "exchange", "with", "the", "medium", "depended", "on", "added", "C1424510#ent", "<e2>"], "h": {"id": "C1417504", "name": "C1417504#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1424510", "name": "C1424510#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "in", "both", "nasopharyngeal", "carcinoma", "prostate", "cancer", "cells", "C1333565#ent", "<e1>", "expression", "was", "found", "to", "protect", "the", "cells", "from", "chemotherapeutic", "C0011609#ent", "<e2>", "regulation", "of", "the", "Raf-1/MAPK", "and", "JNK", "pathways", "."], "h": {"id": "C1333565", "name": "C1333565#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011609", "name": "C0011609#ent", "pos": [21, 22]}}
{"token": ["Our", "findings", "also", "suggest", "a", "potential", "therapeutic", "strategy", "which", "inactivation", "of", "C1333565#ent", "<e1>", "may", "lead", "to", "sensitization", "of", "prostate", "cancer", "cells", "to", "chemotherapeutic", "C0011609#ent", "<e2>"], "h": {"id": "C1333565", "name": "C1333565#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011609", "name": "C0011609#ent", "pos": [23, 24]}}
{"token": ["As", "residents", "of", "sub-Saharan", "Africa", "at", "high", "risk", "HIV", "and", "C0008354#ent", "<e1>", ",", "it", "is", "biologically", "plausible", "that", "immune", "suppression", "by", "C0019693#ent", "<e2>", "to", "C0008354#ent", "<e1>", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [21, 22]}}
{"token": ["Mutations", "in", "the", "down-regulated", "in", "adenoma", "(", "C1706048#ent", "<e1>", ")", "gene", "cause", "C0011991#ent", "<e2>", "the", "transport", "characteristics", "of", "human", "C1706048#ent", "<e1>", "have", "not", "been", "studied", "in", "a", "heterologous", "human", "expression", "system"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706048", "name": "C1706048#ent", "pos": [7, 8]}}
{"token": ["A", "similar", "experiment", "using", "a", "C1705761#ent", "<e1>", "deletion", "mutant", "revealed", "that", "the", "carboxy-terminal", "portion", "C1705761#ent", "<e1>", "was", "required", "for", "binding", "to", "C1332722#ent", "<e1>", "."], "h": {"id": "C1705761", "name": "C1705761#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332722", "name": "C1332722#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "while", "C1420166#ent", "<e1>", "seems", "to", "work", "in", "concert", "with", "Oatp1", "and", "C3812257#ent", "<e2>", "in", "the", "basolateral", "membrane", "rat", "hepatocytes", ",", "Oatp3", "is", "a", "multispecific", "transport", "system", "the", "small", "intestine"], "h": {"id": "C1420166", "name": "C1420166#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3812257", "name": "C3812257#ent", "pos": [13, 14]}}
{"token": ["The", "neurological", "complications", "C0019693#ent", "<e1>", "bacterial", "and", "C0085438#ent", "<e2>", "intracranial", "mass", "lesions", "acute", "disseminated", "encephalomyelitis", "a", "variety", "of", "spinal", "cord", "disorders", "and", "peripheral", "nerve", "dysfunction"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085438", "name": "C0085438#ent", "pos": [7, 8]}}
{"token": ["A", "49-year-old", "woman", "with", "C0003873#ent", "<e1>", "a", "motor", "polyneuropathy", "nystagmus", "after", "5", "months", "'", "treatment", "with", "C0055447#ent", "<e2>"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0055447", "name": "C0055447#ent", "pos": [16, 17]}}
{"token": ["In", "sharp", "contrast", ",", "VM", "C1836075#ent", "<e1>", "almost", "completely", "lost", "their", "ability", "to", "become", "neurons", "and", "C0041491#ent", "<e2>", "TH(+", ")", ")", "neurons", "after", "expansion", "."], "h": {"id": "C1836075", "name": "C1836075#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041491", "name": "C0041491#ent", "pos": [16, 17]}}
{"token": ["C0146011#ent", "<e1>", ",", "noradrenaline", "and", "C0009014#ent", "<e2>", "depressed", "neuronal", "responses", "to", "noxious", "but", "not", "innocuous", "stimuli", "."], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [5, 6]}}
{"token": ["The", "order", "of", "relative", "selectivity", "to", "imidazoline", "receptor", "C0146011#ent", "<e1>", "greater", "than", "oxymetazoline", "greater", "than", "C0009014#ent", "<e2>", "greater", "than", "naphazoline", ",", "where", "C0009014#ent", "<e2>", "showed", "an", "equal", "affinity", "to", "both", "receptors", "."], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [15, 16]}}
{"token": ["Resistance", "to", "C1170000#ent", "<e1>", "APC", "resistance", ")", "is", "an", "important", "and", "common", "risk", "factor", "C0149871#ent", "<e2>"], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [14, 15]}}
{"token": ["Under", "these", "conditions", ",", "C0051150#ent", "<e1>", "pharmacokinetics", "were", "only", "marginally", "affected", "by", "concomitant", "C0008783#ent", "<e2>", "administration", "."], "h": {"id": "C0051150", "name": "C0051150#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [13, 14]}}
{"token": ["Combinations", "of", "FR160", "with", "C0280858#ent", "<e1>", ",", "diltiazem", ",", "clotrimazole", ",", "amiloride", ",", "diazoxide", ",", "C0000477#ent", "<e2>", ",", "and", "picrotoxin", "should", "be", "avoided", "(", "antagonistic", "effects", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [15, 16]}}
{"token": ["The", "incidence", "of", "VT", "was", "also", "attenuated", "by", "C0280858#ent", "<e1>", ",", "but", "not", "by", "C0000477#ent", "<e2>", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "on", "Na(+", ")", "transport", "is", "specific", "for", "C0280858#ent", "<e1>", ",", "since", "nifedipine", ",", "Ba(2", "+", ")", ",", "C0000477#ent", "<e2>", ",", "and", "charybdotoxin", "do", "not", "significantly", "affect", "I(sc", ")", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [19, 20]}}
{"token": ["C0280858#ent", "<e1>", "and", "manganese", "inhibited", "C0000477#ent", "<e2>", ",", "caffeine", "and", "quinine-induced", "contractures", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [5, 6]}}
{"token": ["Both", "C0243192#ent", "<e1>", "increased", "the", "phosphorylation", "(", "activation", ")", "of", "C0257535#ent", "<e2>", "by", "approximately", "12-fold", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [10, 11]}}
{"token": ["Treatment", "of", "lambda", "phage", "with", "C0039294#ent", "<e1>", "cleavage", "with", "restriction", "endonucleases", "C1335822#ent", "<e2>", "and", "EcoRI", "*", "but", "not", "with", "SmaI", "and", "HaeIII", "."], "h": {"id": "C0039294", "name": "C0039294#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335822", "name": "C1335822#ent", "pos": [11, 12]}}
{"token": ["Immunohistology", "demonstrated", "that", "the", "cells", "in", "the", "seminiferous", "tubules", "damaged", "by", "the", "C0013227#ent", "<e1>", "and", "confirmed", "that", "they", "were", "C1334435#ent", "<e2>", "and", "p53", "positive", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334435", "name": "C1334435#ent", "pos": [19, 20]}}
{"token": ["A", "monoclonal", "antibody", "mAb", ")", "binding", "to", "protein", "C", "C3811118#ent", "<e1>", ")", "C1420192#ent", "<e2>", "not", "to", "activated", "C3811118#ent", "<e1>", "was", "found", "to", "inhibit", "C3811118#ent", "<e1>", "activation", "by", "free", "thrombin", "suggesting", "that", "epitope", "involved", "the", "activation", "site"], "h": {"id": "C1420192", "name": "C1420192#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [9, 10]}}
{"token": ["C0022679#ent", "<e1>", "the", "most", "common", "genetic", "cause", "C2316810#ent", "<e2>", "children", "and", "young", "adults"], "h": {"id": "C0022679", "name": "C0022679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [7, 8]}}
{"token": ["The", "C0034861#ent", "<e1>", "recognized", "by", "sera", "of", "patients", "with", "proven", "C0030409#ent", "<e2>", "and", "not", "by", "sera", "of", "healthy", "individuals", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030409", "name": "C0030409#ent", "pos": [10, 11]}}
{"token": ["The", "hepato-renal", "syndrome", "defined", "as", "potentially", "reversible", "functional", "renal", "failure", "associated", "with", "C0302809#ent", "<e1>", ",", "more", "often", ",", "with", "advanced", "C2936476#ent", "<e2>"], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2936476", "name": "C2936476#ent", "pos": [20, 21]}}
{"token": ["To", "describe", "a", "case", "of", "the", "C1848862#ent", "<e1>", "of", "inappropriate", "antidiuretic", "hormone", "secretion", "SIADH", ")", "associated", "with", "C0065374#ent", "<e2>"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [17, 18]}}
{"token": ["Cyclic", "adenosine", "response", "element-binding", "protein", "(", "CREB", ")", ",", "with", "the", "specific", "co-activator", ",", "the", "CREB-binding", "protein", "C1705776#ent", "<e1>", ")", ",", "contributes", "to", "the", "acetylation", "of", "C0008546#ent", "<e2>", "and", "to", "the", "transcription", "of", "pro-inflammatory", "genes"], "h": {"id": "C1705776", "name": "C1705776#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [26, 27]}}
{"token": ["The", "distribution", "of", "C0382507#ent", "<e1>", "the", "ipsilateral", "C1416842#ent", "<e2>", "differed", "according", "to", "the", "injection", "site"], "h": {"id": "C0382507", "name": "C0382507#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416842", "name": "C1416842#ent", "pos": [7, 8]}}
{"token": ["Although", "no", "C1415831#ent", "<e1>", "IV-mediated", "metabolism", "of", "angiotensin", "II", "AII", ")", "or", "angiotensin", "III", "C1424250#ent", "<e2>", ")", "was", "measured", ",", "both", "AmM", "and", "AmA", "metabolized", "AII", "and", "C1424250#ent", "<e2>", "."], "h": {"id": "C1415831", "name": "C1415831#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [14, 15]}}
{"token": ["We", "have", "previously", "identified", "megakaryocyte", "stimulating", "factor", "C1367472#ent", "<e1>", ")", "gene", "expression", "synovial", "fibroblasts", "the", "origin", "of", "C1418891#ent", "<e2>", "in", "the", "synovial", "cavity"], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418891", "name": "C1418891#ent", "pos": [17, 18]}}
{"token": ["Activation", "of", "oncogenes", "is", "considered", "for", "K-ras", ",", "the", "cyclin", "D1", "the", "C1415636#ent", "<e1>", "hnRNPA2/B1", ")", ",", "and", "finally", "the", "C0079068#ent", "<e2>", "oncogene", "."], "h": {"id": "C1415636", "name": "C1415636#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [20, 21]}}
{"token": ["A", "direct", "surgical", "approach", "the", "biliary", "tree", "prolonged", "transhepatic", "stenting", "is", "indicated", "in", "patients", "with", "severe", "hilar", "or", "extrahepatic", "stricturing", "persistent", "jaundice", "and/or", "C0746495#ent", "<e1>", "and", "no", "evidence", "of", "C1623038#ent", "<e2>", "."], "h": {"id": "C0746495", "name": "C0746495#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [29, 30]}}
{"token": ["Because", "C0014378#ent", "<e1>", "71", "is", "more", "often", "associated", "with", "severe", "C0027765#ent", "<e2>", "there", "is", "a", "need", "to", "rapidly", "discriminate", "between", "C0014378#ent", "<e1>", "71", "and", "coxsackievirus", "A16", "hand", ",", "foot", ",", "and", "mouth", "disease", "outbreaks", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014378", "name": "C0014378#ent", "pos": [1, 2]}}
{"token": ["Human", "T-lymphotropic", "virus", "type", "I", "myelopathy/tropical", "spastic", "paraparesis", "(", "HAM/TSP", ")", "is", "a", "C0027765#ent", "<e1>", "results", "from", "an", "interaction", "of", "C0014378#ent", "<e2>", "immune", "activation"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014378", "name": "C0014378#ent", "pos": [20, 21]}}
{"token": ["They", "include", "the", "C1848862#ent", "<e1>", "of", "inappropriate", "antidiuretic", "hormone", "pancreatitis", ";", "cholelithiasis", ";", "C1412000#ent", "<e2>", "ileus", ";", "pnemothorax", ";", "hemothorax", ";", "chylothorax", ";", "and", "fat", "embolism"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412000", "name": "C1412000#ent", "pos": [13, 14]}}
{"token": ["The", "presence", "of", "AADC", "autoantibodies", "patients", "with", "C0085859#ent", "<e1>", "a", "subgroup", "of", "C0001403#ent", "<e2>", "patients", "who", "may", "have", "a", "milder", "atypical", "form", "of", "C0085859#ent", "<e1>", "represent", "a", "distinct", "entity", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0085859", "name": "C0085859#ent", "pos": [7, 8]}}
{"token": ["The", "stem", "cell", "therapy", "be", "the", "solution", "of", "curing", "many", "severe", "diseases", "such", "as", "osteogenesis", "imperfecta", "hepatic", "failure", "heart", "muscle", "damage", "myocardial", "infarction", "C0011860#ent", "<e1>", "variety", "of", "C0007682#ent", "<e2>", "as", "brain", "injury", "stroke", ",", "Parkinson's", "disease", "other", "neurodegenerative", "disorders"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [27, 28]}}
{"token": ["The", "mutagenicity", "of", "C0001975#ent", "<e1>", "isolated", "purified", "metabolites", "determined", "in", "the", "C0036117#ent", "<e2>", "mammalian", "microsome", "plate", "assay", "(", "Ames", "test", ")", "with", "strain", "TA100", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [11, 12]}}
{"token": ["This", "finding", "suggests", "that", "differences", "in", "the", "reversibility", "of", "C0020207#ent", "<e1>", "may", "correlate", "with", "the", "usefulness", "of", "the", "C0013227#ent", "<e2>", "in", "the", "therapy", "of", "schistosome", "infections", "different", "species", "of", "parasites", "."], "h": {"id": "C0020207", "name": "C0020207#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "C1870471#ent", "<e1>", ",", "when", "compared", "with", "phenylalanine", "showed", "opposite", "effects", "on", "the", "enzyme", "activity", "suggesting", "that", "phenylalanine", "and", "C1870471#ent", "<e1>", "bind", "to", "two", "different", "sites", "on", "the", "C0027203#ent", "<e1>", "."], "h": {"id": "C1870471", "name": "C1870471#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [29, 30]}}
{"token": ["Thus", ",", "C0019693#ent", "<e1>", "not", "influence", "the", "effect", "of", "adrenaline", "on", "IL-6", "and", "C0245109#ent", "<e2>", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0245109", "name": "C0245109#ent", "pos": [13, 14]}}
{"token": ["Together", "with", "previous", "data", ",", "these", "results", "confirm", "that", "a", "catalytic", "dyad", "of", "His176", "and", "Cys231", "is", "responsible", "for", "C1333187#ent", "<e1>", "in", "the", "C0010656#ent", "<e2>"], "h": {"id": "C1333187", "name": "C1333187#ent", "pos": [19, 20]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [23, 24]}}
{"token": ["The", "identification", "of", "C1333187#ent", "<e1>", "help", "to", "design", "C0010656#ent", "<e2>", "inhibitors", "."], "h": {"id": "C1333187", "name": "C1333187#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [8, 9]}}
{"token": ["Expressed", "C1414244#ent", "<e1>", "was", "inhibited", "by", "C0070915#ent", "<e2>", ",", "but", "not", "by", "thiorphan", "."], "h": {"id": "C1414244", "name": "C1414244#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0070915", "name": "C0070915#ent", "pos": [6, 7]}}
{"token": ["At", "follow-up", ",", "two", "patients", "had", "C3272265#ent", "<e1>", "ten", "two-vessel", "disease", "seven", "C3275121#ent", "<e2>"], "h": {"id": "C3272265", "name": "C3272265#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [12, 13]}}
{"token": ["Forty-three", "patients", "have", "severe", "CAD", "(", "two-", "or", "C3272265#ent", "<e1>", "and", "24", "patients", "have", "less", "pronounced", "CAD", "(", "C3275121#ent", "<e2>", "less", "than", "50", "%", "narrowing", "of", "coronary", "vessels", "."], "h": {"id": "C3272265", "name": "C3272265#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [18, 19]}}
{"token": ["Bortezomib-induced", "apoptosis", "was", "associated", "with", "activation", "of", "caspase", "3", "cleavage", "of", "C1567710#ent", "<e1>", "and", "induction", "of", "p27", "and", "C1420626#ent", "<e2>", "expression", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [18, 19]}}
{"token": ["However", ",", "in", "this", "emerging", "pathway", "the", "role", "of", "previously", "identified", "components", "of", "C3273763#ent", "<e1>", "NF-kappaB", "activation", ",", "namely", "phosphatidylcholine-specific", "phospholipase", "C", "C0033634#ent", "<e2>", "remains", "unclear", "."], "h": {"id": "C3273763", "name": "C3273763#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [22, 23]}}
{"token": ["C3273763#ent", "<e1>", "activation", "of", "neutral", "SMase", "was", "inhibited", "by", "stimulation", "of", "C0033634#ent", "<e2>", "PKC", ")", "by", "the", "phorbol", "ester", "TPA", "which", "caused", "a", "reduction", "of", "ceramide", "back", "to", "control", "levels"], "h": {"id": "C3273763", "name": "C3273763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [11, 12]}}
{"token": ["Fever", ",", "fatigue", ",", "leukopenia", ",", "anemia", ",", "C0040034#ent", "<e1>", "and", "elevation", "of", "GOT", "and", "C1415274#ent", "<e2>", "were", "observed", "relatively", "frequently", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415274", "name": "C1415274#ent", "pos": [15, 16]}}
{"token": ["The", "two", "heparin", "inhibitable", "C3541394#ent", "<e1>", "bind", "to", "heparin", "affinity", "columns", "but", "the", "C0016964#ent", "<e2>", "does", "not", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [13, 14]}}
{"token": ["These", "organelles", "contained", "marker", "C3541394#ent", "<e1>", "for", "the", "Golgi", "complex", "C0016964#ent", "<e2>", "and", "lysosomes", "(", "cathepsins", ")", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [10, 11]}}
{"token": ["The", "C3541394#ent", "<e1>", "studied", "include", "UDP-Gal", ":", "C0016964#ent", "<e2>", "UDP-Gal", ":", "glucosylceramide", "galactosyltransferase", "UDP-Gal", ":", "galactosylceramide", "galactosyltransferase", "and", "CMP-NAN", ":", "lactosylceramide", "sialytransferase", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [7, 8]}}
{"token": ["Activity", "measurements", "of", "marker", "C3541394#ent", "<e1>", ",", "phosphodiesterase", "and", "C0016964#ent", "<e2>", ",", "suggest", "that", "medium", "coated", "vesicles", "might", "originate", "from", "plasma", "membranes", "small", "ones", "the", "Golgi", "complex"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [9, 10]}}
{"token": ["Presumably", "the", "C0014894#ent", "<e1>", "is", "some", "type", "of", "acetylesterase", "or", "C0001053#ent", "<e2>", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001053", "name": "C0001053#ent", "pos": [10, 11]}}
{"token": ["Blood", "and", "bone-marrow", "smears", "adult", "patients", "with", "acute", "leukemias", "stained", "for", "C0014894#ent", "<e1>", "consecutively", "with", "naphthol", "AS", "D-chloracetate", "(", "C0001053#ent", "<e2>", "followed", "by", "alpha", "naphthyl", "butyrate", "nonspecific", "esterase", ")", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001053", "name": "C0001053#ent", "pos": [19, 20]}}
{"token": ["Two", "different", "substrates", ",", "C0005096#ent", "<e1>", "and", "androstenedione", ",", "that", "are", "C0025517#ent", "<e2>", "by", "cytochrome", "P450", "2B4", "pronounced", "product", "specificity", "docked", "into", "the", "putative", "binding", "site"], "h": {"id": "C0005096", "name": "C0005096#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [11, 12]}}
{"token": ["The", "results", "indicate", "that", "the", "C0072522#ent", "<e1>", "were", "of", "high", "molecular", "weight", "could", "be", "dissociated", "by", "C1426244#ent", "<e2>", "into", "a", "multitude", "of", "molecules", "or", "subunits", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1426244", "name": "C1426244#ent", "pos": [16, 17]}}
{"token": ["Liver", "nuclei", ",", "prepared", "from", "normal", "and", "vitamin", "A-deficient", "rats", ",", "were", "incubated", "in", "the", "presence", "of", "GDP-(14C)mannose", "or", "UDP-N-acetyl(14C)glucosamine", "and", "the", "labelled", "C0072522#ent", "<e1>", "analysed", "by", "C1426244#ent", "<e2>", "PAGE", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1426244", "name": "C1426244#ent", "pos": [27, 28]}}
{"token": ["Treatment", "of", "the", "C0072522#ent", "<e1>", "with", "2", "%", "beta-mercaptoethanol", "and", "0.1", "%", "C1426244#ent", "<e2>", "favoured", "the", "formation", "of", "a", "single", "component", "with", "a", "mol", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1426244", "name": "C1426244#ent", "pos": [12, 13]}}
{"token": ["Lysophosphatidic", "acid", "acyltransferase", "C2742256#ent", "<e1>", ")", "is", "an", "C0021699#ent", "<e2>", "catalyzes", "the", "synthesis", "of", "phosphatidic", "acid", "PA", ")", "from", "lysophosphatidic", "acid", "LPA", ")", "."], "h": {"id": "C2742256", "name": "C2742256#ent", "pos": [3, 4]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}}
{"token": ["Groups", "of", "mice", "were", "challenged", "with", "either", "the", "wild-type", "C3272493#ent", "<e1>", "or", "a", "C1705065#ent", "<e2>", "deletion", "derivative", "thereof", "."], "h": {"id": "C3272493", "name": "C3272493#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [13, 14]}}
{"token": ["We", "also", "show", "that", "it", "is", "possible", "in", "this", "pilot", "case", "differentiate", "clinical", "and", "C0751112#ent", "<e1>", "on", "the", "C0058836#ent", "<e2>", "features", "of", "the", "synchronization", "."], "h": {"id": "C0751112", "name": "C0751112#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0058836", "name": "C0058836#ent", "pos": [18, 19]}}
{"token": ["C0537740#ent", "<e1>", "TK2", ")", "is", "a", "deoxyribonucleoside", "kinase", "C1333327#ent", "<e2>", "deoxycytidine", ",", "and", "deoxyuridine", "."], "h": {"id": "C0537740", "name": "C0537740#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333327", "name": "C1333327#ent", "pos": [8, 9]}}
{"token": ["We", "quantify", "changes", "in", "the", "size", "and", "turnover", "of", "the", "dTTP", "pool", "after", "inhibition", "of", "C0537740#ent", "<e1>", "by", "RNA", "interference", "of", "p53R2", "with", "hydroxyurea", ",", "and", "of", "C1333327#ent", "<e2>", "5-bromouracil", "."], "h": {"id": "C0537740", "name": "C0537740#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333327", "name": "C1333327#ent", "pos": [27, 28]}}
{"token": ["We", "have", "synthesized", "a", "novel", "small", "molecule", "A-420983", ",", "which", "inhibits", "Lck", "and", "C1442788#ent", "<e1>", ",", "as", "well", "as", "other", "C0038085#ent", "<e2>", "but", "has", "selectivity", "with", "respect", "to", "non-Src", "family", "kinases"], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [20, 21]}}
{"token": ["Immunoprecipitation", "of", "C1442788#ent", "<e1>", ",", "a", "member", "of", "the", "C0038085#ent", "<e2>", "from", "Abeta(25", "-", "35)-treated", "neurons", "showed", "an", "increased", "association", "of", "C1442788#ent", "<e1>", "with", "FAK", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [9, 10]}}
{"token": ["We", "hypothesized", "that", "C0054836#ent", "<e1>", "may", "modulate", "presynaptic", "C3887648#ent", "<e2>", "release", "in", "the", "heart", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "the", "C0443121#ent", "<e1>", "did", "increase", "plasma", "C1425569#ent", "<e2>", "to", "the", "expected", "level", ",", "and", "this", "C1425569#ent", "<e2>", "bound", "readily", "to", "the", "patient's", "platelets", "in", "the", "presence", "of", "ristocetin", "."], "h": {"id": "C0443121", "name": "C0443121#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [9, 10]}}
{"token": ["Here", ",", "we", "show", "that", "both", "hypoxia", "and", "hypoxia/reoxygenation", "caused", "rapid", "activation", "of", "the", "C0257151#ent", "<e1>", "MAPKKK", ")", ",", "activity", "of", "C1706586#ent", "<e2>", "."], "h": {"id": "C0257151", "name": "C0257151#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "mitogen-activated", "protein", "kinase", "response", "kinase", "(", "ERK", ")", "and", "its", "upstream", "kinases", ",", "C0257151#ent", "<e1>", "MEK", ")", "and", "C1706586#ent", "<e2>", ",", "were", "activated", "by", "IGF-I", "in", "floating", "cells"], "h": {"id": "C0257151", "name": "C0257151#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [21, 22]}}
{"token": ["The", "phosphorylation", "of", "protein", "tyrosine", "extracellular", "signal-regulated", "protein", "kinase", "C0164786#ent", "<e1>", "caused", "by", "C1705725#ent", "<e2>", "were", "attenuated", "by", "cirsimaritin", "in", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [13, 14]}}
{"token": ["Drosophila", "C3537342#ent", "<e1>", "is", "not", "a", "substrate", "for", "C0033640#ent", "<e2>", "of", "phosphorylating", "the", "beta", "subunit", "C3537342#ent", "<e1>", "from", "rabbit", "reticulocytes", "."], "h": {"id": "C3537342", "name": "C3537342#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [8, 9]}}
{"token": ["The", "C0022614#ent", "<e1>", "induced", "increase", "in", "GABA", "was", "abolished", "by", "C0073047#ent", "<e2>", "but", "not", "by", "SCH23390", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0073047", "name": "C0073047#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "the", "antiatherosclerotic", "effects", "of", "C0246444#ent", "<e1>", ",", "we", "examined", "its", "effect", "on", "experimental", "C0003850#ent", "<e2>", "induced", "by", "feeding", "a", "high-cholesterol", "diet", "to", "monkeys", ",", "whose", "lipid", "metabolism", "that", "of", "humans", "."], "h": {"id": "C0246444", "name": "C0246444#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [15, 16]}}
{"token": ["However", ",", "the", "long-term", "effects", "of", "C0246444#ent", "<e1>", "on", "the", "progression", "of", "C0003850#ent", "<e2>", "remain", "to", "be", "determined", "."], "h": {"id": "C0246444", "name": "C0246444#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [12, 13]}}
{"token": ["C0246444#ent", "<e1>", "might", "become", "an", "effective", "C0003850#ent", "<e2>", "drug", "."], "h": {"id": "C0246444", "name": "C0246444#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [6, 7]}}
{"token": ["The", "efficacy", "and", "safety", "of", "the", "new", "cardioselective", "beta-blocker", "bisoprolol", "mg", "and", "10", "mg", "once", "daily", "in", "the", "treatment", "of", "C0002962#ent", "<e1>", "compared", "with", "C0004147#ent", "<e2>", "100", "mg", "once", "daily", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [20, 21]}, "relation": "may_be_treated_by", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [24, 25]}}
{"token": ["Myocardial", "substrate", "extraction", "coronary", "sinus", "flow", "left", "ventricular", "pressure", "and", "cardiac", "output", "measured", "in", "11", "patients", "with", "C0002962#ent", "<e1>", "three", "pacing", "rates", "before", "and", "after", "C0004147#ent", "<e2>", "(", "0.2", "mg/kg", ")", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [25, 26]}}
{"token": ["In", "the", "present", "study", ",", "20", "patients", "with", "both", "hypertension", "and", "stabile", "C0002962#ent", "<e1>", "treated", "twice", "daily", "for", "6", "months", "with", "50", "mg", "C0004147#ent", "<e2>", "and", "20", "mg", "retard-formulation", "nifedipine", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [23, 24]}}
{"token": ["The", "reported", "C0001648#ent", "<e1>", "antagonism", "of", "amiodarone", "did", "not", "change", "C3536742#ent", "<e2>", "dose", "requirements", "in", "this", "study", "."], "h": {"id": "C0001648", "name": "C0001648#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [10, 11]}}
{"token": ["C0001648#ent", "<e1>", "not", "explain", "these", "findings", "since", "C3536742#ent", "<e2>", "release", "declined", "during", "occlusion", "and", "reperfusion", "."], "h": {"id": "C0001648", "name": "C0001648#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [7, 8]}}
{"token": ["Attachment", "of", "a", "C0919282#ent", "<e1>", "or", "methylenecarboxamide", "moiety", "to", "the", "C0043775#ent", "<e2>", "chelator", "portion", "of", "fluo-4", "allowed", "for", "the", "attachment", "of", "dextrans", ",", "protein-reactive", "moieties", ",", "and", "biotin", "."], "h": {"id": "C0919282", "name": "C0919282#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0043775", "name": "C0043775#ent", "pos": [10, 11]}}
{"token": ["Human", "topoisomerase", "IIalpha", "TOP2A", ")", "is", "encoded", "by", "the", "TOP2A", "gene", "chromosome", "17q21", "22", ",", "and", "C1504636#ent", "<e1>", "TOP2B", ")", "is", "encoded", "by", "the", "C1336658#ent", "<e2>", "chromosome", "3p24"], "h": {"id": "C1504636", "name": "C1504636#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1336658", "name": "C1336658#ent", "pos": [24, 25]}}
{"token": ["Addition", "of", "C0037688#ent", "<e1>", "or", "glycerol", "enhanced", "C0031669#ent", "<e2>", "activity", "of", "H.", "pylori", "and", "purified", "C0031669#ent", "<e2>", "from", "C.", "perfringens", "PLC1", ")", "but", "not", "purified", "C0031669#ent", "<e2>", "from", "B.", "cereus", "(", "PLC3", ")", "."], "h": {"id": "C0037688", "name": "C0037688#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [7, 8]}}
{"token": ["Contrast-detail", "(", "CD", ")", "analysis", "was", "used", "to", "compare", "the", "low-contrast", "detectability", "of", "computed", "radiography", "CR", ")", "and", "screen-film", "(", "C1366480#ent", "<e1>", ")", "as", "applied", "to", "the", "C0310298#ent", "<e2>", "of", "adult", "chest", "radiography"], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [27, 28]}}
{"token": ["The", "effect", "of", "histamine", "was", "blocked", "by", "the", "C3536872#ent", "<e1>", "cimetidine", "but", "not", "the", "C2919009#ent", "<e2>", "diphenhydramine", "(", "P", "<", "0.01", ")", "."], "h": {"id": "C3536872", "name": "C3536872#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2919009", "name": "C2919009#ent", "pos": [14, 15]}}
{"token": ["Peptides", "related", "to", "melanotropin", "(", "C1704950#ent", "<e1>", ")", "and", "corticotropin", "(", "C1704793#ent", "<e2>", ")", ",", "collectively", "termed", "melanocortins", ",", "are", "known", "to", "improve", "the", "postlesion", "repair", "of", "injured", "peripheral", "nerves"], "h": {"id": "C1704950", "name": "C1704950#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "the", "CD4+", "C1705743#ent", "<e1>", "responded", "to", "C1420466#ent", "<e2>", "that", "had", "been", "pulsed", "with", "hsp70", "."], "h": {"id": "C1705743", "name": "C1705743#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420466", "name": "C1420466#ent", "pos": [9, 10]}}
{"token": ["Local", "application", "the", "noncompetitive", "N-methyl-D-aspartate", "receptor", "antagonist", "C0813872#ent", "<e1>", "had", "no", "effect", "on", "the", "tail", "pinch-stimulated", "increase", "in", "C0376261#ent", "<e2>", "in", "the", "striatum", "."], "h": {"id": "C0813872", "name": "C0813872#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "the", "roles", "of", "C0033551#ent", "<e1>", "(", "COX", ")", "isozymes", "and", "prostaglandin", "E", "PGE", ")", "receptor", "C1419061#ent", "<e2>", "and", "EP3", "subtypes", "or", "prostacyclin", "IP", "receptors", "the", "decrease", "in", "acid", "secretion", "the", "damaged", "mouse", "stomach"], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419061", "name": "C1419061#ent", "pos": [17, 18]}}
{"token": ["We", "also", "showed", "Rap1", "and", "C1370600#ent", "<e1>", "activation", "by", "both", "C1442521#ent", "<e2>", "HGF", ")", "and", "8CPT-2Me-cAMP", "(", "an", "activator", "of", "Epac", ",", "a", "Rap1", "guanine", "nucleotide", "exchange", "factor", "in", "two", "human", "melanoma", "cell", "lines"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "hepatocellular", "carcinoma", "HCC", ")", "using", "a", "combination", "of", "extracellular", "signal", "regulated", "kinase", "C1370600#ent", "<e1>", ")", "and", "other", "markers", "related", "to", "C1442521#ent", "<e2>", "HGF", ")", "in", "tumor", "tissue"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [28, 29]}}
{"token": ["Extensive", "fluorescence", "in", "situ", "hybridization", "analysis", "that", "the", "C1704834#ent", "<e1>", "critical", "gene", "region", "inclusive", "Sonic", "hedgehog", "SHH", ")", ",", "C1414396#ent", "<e2>", "(", "HOX1", ")", ",", "and", "HTR5A", ",", "was", "deleted", "."], "h": {"id": "C1704834", "name": "C1704834#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414396", "name": "C1414396#ent", "pos": [19, 20]}}
{"token": ["Rea1", "and", "the", "C1420072#ent", "<e1>", "complex", "could", "mediate", "C0101555#ent", "<e2>", "remodeling", "of", "60S", "subunits", "subsequent", "export", "from", "the", "nucleoplasm", "to", "the", "cytoplasm", "."], "h": {"id": "C1420072", "name": "C1420072#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [8, 9]}}
{"token": ["Among", "children", "Rasmussen's", "encephalitis", "C0014038#ent", "<e1>", "the", "commonest", "cause", "for", "C0169014#ent", "<e2>", "."], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0169014", "name": "C0169014#ent", "pos": [10, 11]}}
{"token": ["C1366488#ent", "<e1>", "CRF", ")", "has", "been", "shown", "to", "reverse", "effect", "C0030883#ent", "<e2>", "(", "PbNa", ")", "within", "the", "central", "nervous", "system"], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [10, 11]}}
{"token": ["Since", "their", "protein", "products", "been", "found", "associated", "with", "Lgi1", ",", "the", "Kv1", "channel", "subunit", "genes", "C1416543#ent", "<e1>", ",", "KCNA4", ",", "and", "KCNAB1", "and", "C1412192#ent", "<e2>", "can", "be", "considered", "strong", "candidates", "for", "ADLTE", "."], "h": {"id": "C1416543", "name": "C1416543#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412192", "name": "C1412192#ent", "pos": [23, 24]}}
{"token": ["Skin", "diseases", "underlying", "endocrine", "pathology", "include", ":", "thyrotoxicosis", ";", "hypothyroidism", ";", "C0010481#ent", "<e1>", "Addison", "disease", "acromegaly", ";", "hyperandrogenism", ";", "C4025821#ent", "<e2>", ";", "primary", "hyperparathyroidism", "hypoparathyroidism", ";", "pseudohypoparathyroidism", "and", "manifestations", "of", "diabetes", "mellitus"], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4025821", "name": "C4025821#ent", "pos": [19, 20]}}
{"token": ["The", "use", "of", "this", "conventional", "dose", "now", "been", "shown", "to", "result", "in", "mild", "biochemical", "C0010481#ent", "<e1>", "and", "might", "contribute", "to", "the", "increased", "cardiovascular", "risk", "in", "C4025821#ent", "<e2>", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4025821", "name": "C4025821#ent", "pos": [25, 26]}}
{"token": ["The", "most", "frequenly", "involved", "diseases", "include", "thyrotoxicosis", ",", "hypothyroidism", ",", "the", "auto-immune", "disorders", "thyroid", ",", "C0010481#ent", "<e1>", "Addison", "disease", "acromegaly", ",", "androgen-dependent", "disorders", ",", "C4025821#ent", "<e2>", ",", "hypoparathyroidism", ",", "pseudohypoparathyroidism", "and", "diabetes", "mellitus"], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4025821", "name": "C4025821#ent", "pos": [24, 25]}}
{"token": ["We", "have", "isolated", "a", "C0294209#ent", "<e1>", "AO7", ",", "previously", "identified", "as", "an", "C1423524#ent", "<e2>", "a", "ubiquitin-conjugating", "enzyme", "Ubc5B", "."], "h": {"id": "C0294209", "name": "C0294209#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423524", "name": "C1423524#ent", "pos": [12, 13]}}
{"token": ["Ectopic", "expression", "of", "C0134982#ent", "<e1>", "down-regulates", "the", "transcription", "of", "C0812299#ent", "<e2>", "and", "cyclin", "D1", "oncogenes"], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812299", "name": "C0812299#ent", "pos": [9, 10]}}
{"token": ["The", "cardiometabolic", "syndrome", "a", "construct", "associated", "with", "increased", "risk", "of", "C0011860#ent", "<e1>", "cardiovascular", "disease", "coronary", "artery", "disease", "peripheral", "arterial", "disease", "and", "stroke", ")", ",", "C2316401#ent", "<e2>", "and", "the", "metabolic", "hepatopathy", "to", "as", "nonalcoholic", "fatty", "liver", "disease", "nonalcoholic", "steatohepatitis"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2316401", "name": "C2316401#ent", "pos": [24, 25]}}
{"token": ["These", "should", "include", "recommendations", "for", "general", "skin", "care", "examination", "and", "treatment", "for", "C0040261#ent", "<e1>", ",", "patch", "testing", "contact", "eczema", "treatment", "of", "other", "C0018567#ent", "<e2>", ",", "such", "as", "plantar", "psoriasis"], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018567", "name": "C0018567#ent", "pos": [22, 23]}}
{"token": ["C0040261#ent", "<e1>", "a", "very", "recalcitrant", "C0018567#ent", "<e2>", "."], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018567", "name": "C0018567#ent", "pos": [5, 6]}}
{"token": ["Interestingly", ",", "TORID", "overexpression", "in", "bone", "marrow-derived", "DCs", "C2712370#ent", "<e1>", "expression", "of", "C0024518#ent", "<e2>", "CD86", "and", "production", "of", "IL12p40", "following", "activation", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [12, 13]}}
{"token": ["The", "human", "immunodeficiency", "virus", "type", "1", "Nef", "protein", "C2712370#ent", "<e1>", "the", "post-Golgi", "stages", "major", "C0024518#ent", "<e2>", "MHC-I", ")", "biogenesis", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [14, 15]}}
{"token": ["Regulation", "of", "inspiratory", "flow", "C2712370#ent", "<e1>", "the", "outcomes", "of", "the", "methacholine", "(", "C0024518#ent", "<e2>", ")", "challenge", "in", "adults", "and", "cough", "receptor", "sensitivity", "in", "children", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "transcription", "coactivator", "PBP/TRAP220/MED1", "is", "involved", "in", "the", "regulation", "of", "hepatic", "CAR", "function", "and", "that", "C1705594#ent", "<e1>", "deficiency", "in", "liver", "abrogates", "C0000970#ent", "<e2>", "hepatotoxicity", "."], "h": {"id": "C1705594", "name": "C1705594#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [23, 24]}}
{"token": ["C0046183#ent", "<e1>", "and", "N-OH-Trp-P-2", "were", "C0025517#ent", "<e2>", "to", "the", "reactive", "species", "of", "binding", "to", "transfer", "RNA", "a", "putative", "O-acetylation", "process", "by", "liver", "cytosols"], "h": {"id": "C0046183", "name": "C0046183#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "none", "of", "the", "IL-10-related", "cytokines", "described", "so", "far", "could", "activate", "LICR2-transfected", "cells", ",", "suggesting", "that", "C1413696#ent", "<e1>", "is", "a", "signalling", "receptor", "a", "new", "C1333196#ent", "<e2>", "of", "the", "IL-10", "family", "."], "h": {"id": "C1413696", "name": "C1413696#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [26, 27]}}
{"token": ["This", "provides", "evidence", "that", "some", "members", "of", "the", "ALDH", "C1335597#ent", "<e1>", "indeed", "perform", "C0003873#ent", "<e2>", "synthesis", "in", "vivo"], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}}
{"token": ["Deficiency", "in", "this", "enzyme", "activity", "associated", "with", "C0268490#ent", "<e1>", "characterized", "by", "C0268483#ent", "<e2>", ",", "liver", "dysfunction", "renal", "tubular", "dysfunction", "liver", "cirrhosis", "and", "hepatic", "tumors"], "h": {"id": "C0268490", "name": "C0268490#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0268483", "name": "C0268483#ent", "pos": [11, 12]}}
{"token": ["In", "humans", ",", "clinical", "studies", "implicated", "mutations", "in", "19", "of", "the", "48", "known", "ABC", "transporters", "in", "C0012634#ent", "<e1>", "such", "as", "cystic", "fibrosis", "C1412084#ent", "<e2>", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412084", "name": "C1412084#ent", "pos": [22, 23]}}
{"token": ["Cathepsin", "B", "a", "lysosomal", "cysteine", "protease", "is", "synthesized", "as", "a", "C0072522#ent", "<e1>", "with", "two", "N-linked", "oligosaccharide", "chains", "one", "of", "which", "is", "in", "the", "C1709708#ent", "<e2>", "the", "other", "is", "in", "the", "mature", "region", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1709708", "name": "C1709708#ent", "pos": [23, 24]}}
{"token": ["C0162316#ent", "<e1>", "the", "most", "common", "C0018939#ent", "<e2>", "infancy", "and", "childhood", ",", "resulting", "from", "lack", "of", "sufficient", "iron", "for", "synthesis", "of", "hemoglobin", "."], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [5, 6]}}
{"token": ["The", "resistance", "to", "erythropoietin", ",", "which", "is", "used", "to", "treat", "normochromic", ",", "normocytic", "anemia", "chronic", "renal", "failure", "can", "develop", "in", "patients", "with", "conditions", "such", "as", "C0162316#ent", "<e1>", "aluminum", "toxicity", "hyperparathyroidism", ",", "chronic", "inflammatory", "diseases", "and", "C0018939#ent", "<e2>"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [35, 36]}}
{"token": ["The", "neurotoxin", "MPTP", "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine", ")", "induces", "a", "C0019537#ent", "<e1>", "man", "and", "C1334982#ent", "<e2>", "primates", "very", "similar", "to", "idiopathic", "Parkinson's", "disease", "selectively", "destroying", "dopaminergic", "nigrostriatal", "neurons", "."], "h": {"id": "C0019537", "name": "C0019537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334982", "name": "C1334982#ent", "pos": [11, 12]}}
{"token": ["However", ",", "the", "present", "study", "confirms", "that", "C0795843#ent", "<e1>", "anomalies", "can", "be", "associated", "with", "C0014544#ent", "<e2>", "."], "h": {"id": "C0795843", "name": "C0795843#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [14, 15]}}
{"token": ["We", "report", "three", "patients", "with", "a", "pericentric", "inversion", "C0795843#ent", "<e1>", "with", "breakpoints", "localized", "to", "p11-q13", "and", "affected", "by", "C0014544#ent", "<e2>", "or", "EEG", "anomalies", "."], "h": {"id": "C0795843", "name": "C0795843#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [18, 19]}}
{"token": ["In", "normally", "hydrated", "female", "subjects", "on", "an", "unrestricted", "diet", "the", "renal", "excretion", "C3714642#ent", "<e1>", "and", "water", "was", "reduced", "following", "C0000970#ent", "<e2>", "1.5", "g", ")", "administration", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [19, 20]}}
{"token": ["Our", "present", "results", "could", "contribute", "to", "the", "understanding", "of", "the", "molecular", "basis", "the", "previously", "reported", "time", "course", "alteration", "in", "the", "fractional", "excretion", "C3714642#ent", "<e1>", "promoted", "by", "a", "nephrotoxic", "dose", "C0000970#ent", "<e2>", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [29, 30]}}
{"token": ["C0723181#ent", "<e1>", "encompasses", "a", "clinical", "spectrum", "C0021099#ent", "<e2>", "the", "widespread", "exfoliation", "of", "the", "Ritter", "disease", "variant", "C0723181#ent", "<e1>", "."], "h": {"id": "C0723181", "name": "C0723181#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021099", "name": "C0021099#ent", "pos": [6, 7]}}
{"token": ["We", "studied", "the", "prevalence", "of", "the", "factor", "V", "associated", "with", "APC", "resistance", "IgG", "anticardiolipin", "antibodies", "C0796147#ent", "<e1>", ")", "in", "an", "epidemiological", "cohort", "78", "Swedish", "C0024141#ent", "<e2>", "patients", ",", "to", "determine", "their", "roles", "as", "risk", "factors", "thrombosis", "."], "h": {"id": "C0796147", "name": "C0796147#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "we", "demonstrate", "that", "reduced", "FMN", "can", "be", "transferred", "efficiently", "from", "the", "C0030016#ent", "<e1>", "to", "the", "C0066083#ent", "<e2>", "without", "involving", "any", "protein.protein", "complexes", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0066083", "name": "C0066083#ent", "pos": [18, 19]}}
{"token": ["The", "enzyme", "inositol", "oxygenase", "myo-inositol", ":", "C0030016#ent", "<e1>", "E.C.", "1.13.99.1", ")", "is", "a", "C0066083#ent", "<e2>", "that", "converts", "inositol", "into", "glucuronic", "acid", "the", "presence", "of", "molecular", "oxygen"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0066083", "name": "C0066083#ent", "pos": [13, 14]}}
{"token": ["Syk", "(", "C0134982#ent", "<e1>", ")", "is", "a", "72-kDa", ",", "nonreceptor", ",", "C0812288#ent", "<e2>", "becomes", "tyrosine-phosphorylated", "and", "activated", "in", "B", "lymphocytes", "aggregation", "of", "the", "B-cell", "antigen", "receptor"], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812288", "name": "C0812288#ent", "pos": [11, 12]}}
{"token": ["These", "data", "suggest", "that", "C0134982#ent", "<e1>", "is", "a", "candidate", "of", "responsible", "C0812288#ent", "<e2>", "platelet", "activation", "that", "cell", "surface", "glycoprotein", "involved", "in", "the", "activation", "of", "C0134982#ent", "<e1>", "in", "platelets", "."], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812288", "name": "C0812288#ent", "pos": [11, 12]}}
{"token": ["C0134982#ent", "<e1>", "is", "a", "C0812288#ent", "<e2>", "is", "widely", "expressed", "in", "haematopoietic", "cells", "involved", "in", "coupling", "activated", "immunoreceptors", "to", "downstream", "signaling"], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812288", "name": "C0812288#ent", "pos": [4, 5]}}
{"token": ["Although", "the", "mechanism", "of", "quinacrine", "for", "the", "central", "nervous", "system", "still", "unclear", ",", "this", "case", "suggests", "that", "quinacrine", "may", "be", "clinically", "one", "possible", "C0013227#ent", "<e1>", "for", "treating", "C2347435#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [27, 28]}}
{"token": ["Among", "these", ",", "the", "C0013227#ent", "<e1>", "induces", "aggregation", "and", "re-targeting", "of", "C2347435#ent", "<e2>", "to", "endocytic", "compartments"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [11, 12]}}
{"token": ["Due", "to", "its", "favourable", "pharmacokinetic", "profile", ",", "Flupirtine", "is", "considered", "to", "be", "a", "promising", "C0013227#ent", "<e1>", "to", "prevent", "neuronal", "death", "Creutzfeldt-Jakob", "disease", "C2347435#ent", "<e2>", ")", "and", "other", "neurodegenerative", "disorders", "with", "age", ",", "e.g.", "Alzheimer's", "disease"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [22, 23]}}
{"token": ["The", "first", "patient", "was", "a", "47-year-old", "woman", "who", "suffered", "from", "frequent", "C0007785#ent", "<e1>", "deep-vein", "thrombosis", "DVT", ")", "of", "her", "lower", "extremities", "and", "C0524702#ent", "<e2>"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0524702", "name": "C0524702#ent", "pos": [22, 23]}}
{"token": ["Recent", "molecular", "biology", "approaches", "confirmed", "abnormalities", "of", "erythroid", "delta-aminolaevulinic", "acid", "synthase", "the", "cause", "of", "X-linked", ",", "C0221018#ent", "<e1>", "mitochondrial", "DNA", "deletions", "the", "most", "common", "cause", "of", "C0002896#ent", "<e2>"], "h": {"id": "C0221018", "name": "C0221018#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0002896", "name": "C0002896#ent", "pos": [26, 27]}}
{"token": ["The", "DCC", "(", "deleted", "in", "colorectal", "cancer", "candidate", "C0079427#ent", "<e1>", "greater", "than", "1350", "kilobases", "at", "chromosomes", "18q21.1", "encodes", "a", "C0021699#ent", "<e2>", "unknown", "function", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [19, 20]}}
{"token": ["We", "next", "examined", "the", "possibility", "that", "the", "C-termini", "APP-LRP", "interaction", "was", "mediated", "by", "C1412459#ent", "<e1>", ",", "an", "adaptor", "protein", "interacts", "with", "the", "cytoplasmic", "tails", "C1417509#ent", "<e2>", "and", "APP", "."], "h": {"id": "C1412459", "name": "C1412459#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417509", "name": "C1417509#ent", "pos": [24, 25]}}
{"token": ["Intravenously", "injected", "C0031179#ent", "<e1>", "was", "extravasated", "at", "3", "h", "post", "hypertonic", "saline", "injection", "(", "C1705397#ent", "<e2>", ")", "into", "regions", "frequently", "involved", "in", "EID", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [14, 15]}}
{"token": ["The", "nitric", "oxide", "NO", ")", "donors", ",", "sodium", "nitroprusside", "SNP", ")", ",", "S-nitroso-N-acetylpenicillamine", "(", "SNAP", ")", "and", "spermine", "NONOate", "SPER/NO", ")", ",", "activated", "both", "cyclo-oxygenase", "and", "C0031179#ent", "<e1>", "activities", "of", "C1705397#ent", "<e2>", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [30, 31]}}
{"token": ["We", "propose", "that", "C0751783#ent", "<e1>", "and", "DSIF", "cause", "C1335440#ent", "<e2>", "to", "pause", "in", "the", "promoter", "proximal", "region", "hsp70", "."], "h": {"id": "C0751783", "name": "C0751783#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [8, 9]}}
{"token": ["Differentiation", "of", "this", "precursor", "to", "neurons", "that", "express", "markers", "such", "as", "C1419850#ent", "<e1>", ",", "peripherin", ",", "and", "C1880904#ent", "<e2>", "dependent", "upon", "MASH1", "function", "."], "h": {"id": "C1419850", "name": "C1419850#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [17, 18]}}
{"token": ["In", "this", "report", ",", "the", "ATP", "and", "ADP", "C0054741#ent", "<e1>", "ectonucleotidases", "of", "chicken", "gizzard", "smooth", "muscle", "C0023899#ent", "<e2>", "plasma", "membranes", "were", "studied", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["A", "monoclonal", "antibody", "against", "this", "enzyme", "also", "reacted", "with", "the", "pl", "6.0", "C0054741#ent", "<e1>", "of", "rat", "C0023899#ent", "<e2>", "microsomes", ",", "but", "did", "not", "react", "with", "the", "other", "two", "dog", "hepatic", "acyltransferases"], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["The", "N-terminal", "amino", "acid", "sequence", "the", "first", "17", "residues", "of", "the", "purified", "enzymes", "were", "88", "%", "homologous", "to", "that", "of", "the", "C0054741#ent", "<e1>", "from", "rat", "C0023899#ent", "<e2>", "and", "adipose", "tissue"], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [25, 26]}}
{"token": ["We", "have", "cloned", "and", "sequenced", "a", "C0054741#ent", "<e1>", "from", "rat", "C0023899#ent", "<e2>", "and", "purified", "the", "corresponding", "protein", "from", "rat", "blood", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["The", "hereditary", "heterogeneity", "of", "epilepsy", ",", "associated,", ",", "with", "pleiotropy", "of", "C0234533#ent", "<e1>", "(", "with", "or", "without", "epileptoidness", ")", "C1417679#ent", "<e2>", ",", "was", "assumed", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [19, 20]}}
{"token": ["C1823700#ent", "<e1>", "Cefalee", "is", "a", "database", "for", "the", "management", "of", "C0270697#ent", "<e2>", "patients", "developed", "on", "behalf", "of", "the", "Italian", "Neurological", "Association", "for", "Headache", "Research", "(", "ANIRCEF", ")", "."], "h": {"id": "C1823700", "name": "C1823700#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [10, 11]}}
{"token": ["The", "C1334159#ent", "<e1>", "induced", "by", "these", "C0991617#ent", "<e2>", "lasted", "at", "least", "25", "days", ",", "and", "could", "not", "be", "reversed", "by", "the", "transplantation", "of", "normal", "syngenic", "bone", "marrow", "cells", "treated", "animals", "."], "h": {"id": "C1334159", "name": "C1334159#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [6, 7]}}
{"token": ["Traditional", "electrodiagnostic", "studies", "the", "presence", "of", "C0021847#ent", "<e1>", ",", "but", "usually", "are", "much", "less", "able", "to", "demonstrate", "superimposed", "nerve", "compression", "in", "the", "lower", "C0030196#ent", "<e2>", "in", "the", "presence", "of", "C0021847#ent", "<e1>", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [6, 7]}}
{"token": ["Despite", "the", "C0221232#ent", "<e1>", "of", "information", "obtained", "in", "previous", "investigations", ",", "how", "C1419243#ent", "<e2>", "mediates", "homology", "search", "and", "annealing", "remains", "unclear", "."], "h": {"id": "C0221232", "name": "C0221232#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419243", "name": "C1419243#ent", "pos": [12, 13]}}
{"token": ["Polymyositis", "was", "the", "commonest", "C0752352#ent", "<e1>", "adults", "and", "C0026847#ent", "<e2>", "childhood", "."], "h": {"id": "C0752352", "name": "C0752352#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [8, 9]}}
{"token": ["Intratracheal", "injection", "of", "crocidolite", "asbestos", "mice", "leads", "to", "C3714636#ent", "<e1>", "injury", "that", "is", "enhanced", "in", "C1099812#ent", "<e2>", "knock-out", "mice"], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1099812", "name": "C1099812#ent", "pos": [15, 16]}}
{"token": ["KA", "was", "the", "more", "potent", "C0243046#ent", "<e1>", ",", "followed", "by", "C1428947#ent", "<e2>", "and", "quisqualic", "acid"], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1428947", "name": "C1428947#ent", "pos": [10, 11]}}
{"token": ["It", "is", "concluded", "that", "C2348090#ent", "<e1>", "be", "used", "to", "treat", "patients", "with", "C0003850#ent", "<e2>", "may", "inhibit", "the", "tendency", "for", "atherosclerotic", "changes", "and", "thrombosis", "."], "h": {"id": "C2348090", "name": "C2348090#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [12, 13]}}
{"token": ["It", "appeared", "to", "be", "expressed", "C0669365#ent", "<e1>", ",", "in", "that", "cell", "activation", "lipopolysaccharide", "(", "C2697656#ent", "<e2>", ")", "did", "not", "modify", "message", "stability"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [14, 15]}}
{"token": ["Human", "beta-defensins", "are", "expressed", "in", "oral", "tissues", "and", "the", "proteins", "are", "secreted", "in", "saliva", ";", "HBD-1", "expression", "was", "C0669365#ent", "<e1>", ",", "while", "HBD-2", "expression", "was", "induced", "by", "IL-1beta", "and", "C2697656#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [29, 30]}}
{"token": ["The", "authors", "present", "the", "results", "of", "analyses", "of", "cases", "of", "notified", "C0025297#ent", "<e1>", "Slovakia", "in", "1991", "-", "1998", ",", "focused", "on", "C0025292#ent", "<e2>"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025292", "name": "C0025292#ent", "pos": [21, 22]}}
{"token": ["ap", "is", "presumably", "required", "for", "C1710463#ent", "<e1>", "genes", "involved", "in", "C3538717#ent", "<e2>", "and", "haltere", "development", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538717", "name": "C3538717#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "C1418776#ent", "<e1>", "expression", "was", "investigated", "in", "human", "prostate", "cancer", "C3811118#ent", "<e2>", ")", ",", "prostatic", "intraepithelial", "neoplasia", "PIN", ")", ",", "benign", "prostatic", "hyperplasia", "BPH", ")", ",", "and", "normal", "prostate", "NP", ")", "tissues", "."], "h": {"id": "C1418776", "name": "C1418776#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [13, 14]}}
{"token": ["The", "C3540574#ent", "<e1>", "the", "human", "C1417420#ent", "<e2>", "synthetase", "catalyzes", "two", "sequential", "reactions", "with", "significant", "channeling", "of", "the", "intermediate", ",", "methenyltetrahydrofolate", "."], "h": {"id": "C3540574", "name": "C3540574#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417420", "name": "C1417420#ent", "pos": [5, 6]}}
{"token": ["The", "simultaneous", "correction", "of", "tetralogy", "of", "C3541422#ent", "<e1>", "and", "an", "aneurysm", "of", "the", "coronary", "artery", "to", "mucocutaneous", "lymph", "node", "syndrome", "C0026691#ent", "<e2>", ")", "in", "a", "4-year-old", "boy", "was", "successfully", "performed", "."], "h": {"id": "C3541422", "name": "C3541422#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [20, 21]}}
{"token": ["We", "report", "the", "C0002932#ent", "<e1>", "two", "children", "with", "C1842577#ent", "<e2>"], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1842577", "name": "C1842577#ent", "pos": [8, 9]}}
{"token": ["Physical", "examination", "signs", "of", "C0002871#ent", "<e1>", "and", "gingivitis", "with", "hypertrophy", "of", "the", "C0040435#ent", "<e2>", "bleeding", "gums", "as", "well", "as", "bright", "blood", "rectal", "examination"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040435", "name": "C0040435#ent", "pos": [12, 13]}}
{"token": ["Forced", "expression", "of", "C1420175#ent", "<e1>", "prior", "to", "induction", "of", "C1420313#ent", "<e2>", "leads", "to", "rapid", "degradation", "of", "the", "transporter", ",", "whereas", "overexpression", "of", "C1420313#ent", "<e2>", "increases", "formation", "of", "GSVs", "and", "stimulates", "insulin-regulated", "glucose", "uptake"], "h": {"id": "C1420175", "name": "C1420175#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420313", "name": "C1420313#ent", "pos": [9, 10]}}
{"token": ["A", "subset", "of", "C1333891#ent", "<e1>", "activities", "are", "found", "to", "be", "physically", "associated", "with", "C0059946#ent", "<e2>", "remodelling", "enzymes", "and", "may", "assist", "their", "function", "."], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [13, 14]}}
{"token": ["It", "consists", "of", "Tom40", ",", "C1425230#ent", "<e1>", ",", "and", "the", "small", "Tom", "components", "C2680495#ent", "<e2>", "and", "Tom7", "."], "h": {"id": "C1425230", "name": "C1425230#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2680495", "name": "C2680495#ent", "pos": [13, 14]}}
{"token": ["Potential", "C0175683#ent", "<e1>", "noted", "for", "C2825076#ent", "<e2>", "vitamin", "D", "calcium", ",", "phosphorus", "and", "selenium", "."], "h": {"id": "C0175683", "name": "C0175683#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2825076", "name": "C2825076#ent", "pos": [5, 6]}}
{"token": ["A", "binary", "plasmid", "constructed", "to", "contain", "the", "mouse", "metallothionein", "c-DNA", ",", "the", "C0669365#ent", "<e1>", "35S", "promoter", "from", "cauliflower", "mosaic", "virus", "the", "polyadenylation", "signal", "the", "C0340861#ent", "<e2>", "rbcS-E9", "gene", "and", "several", "selectable", "markers", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0340861", "name": "C0340861#ent", "pos": [24, 25]}}
{"token": ["Furthermore", ",", "we", "have", "also", "demonstrated", "that", "the", "C0669365#ent", "<e1>", "expression", "of", "C0340861#ent", "<e2>", "ABR17", "cDNA", "in", "Arabidopsis", "thaliana", "Brassica", "napus", "their", "germination", "and", "early", "seedling", "growth", "under", "stress", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0340861", "name": "C0340861#ent", "pos": [12, 13]}}
{"token": ["Intracerebroventricular", "administration", "of", "HA", ",", "the", "H1-receptor", "agonists", "2(3-bromophenyl)HA", "and", "2-thiazolylethylamine", ",", "or", "the", "H2-receptor", "agonists", "C0171368#ent", "<e1>", "or", "4-methyl-HA", "stimulated", "C1366535#ent", "<e2>", "secretion", "."], "h": {"id": "C0171368", "name": "C0171368#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [21, 22]}}
{"token": ["This", "study", "has", "evaluated", "the", "efficacy", "of", "low-frequency", "sonophoresis", "LFS", ")", "at", "25", "kHz", "produced", "by", "a", "sonicator", "apparatus", "treatment", "of", "C0002171#ent", "<e1>", "melasma", ",", "and", "C0036651#ent", "<e2>"], "h": {"id": "C0002171", "name": "C0002171#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0036651", "name": "C0036651#ent", "pos": [26, 27]}}
{"token": ["This", "is", "the", "first", "report", "of", "a", "prolonged", "increase", "in", "both", "the", "activity", "ratio", "C1956039#ent", "<e1>", "the", "activity", "of", "C0029282#ent", "<e2>", "response", "to", "a", "single", "carcinogenic", "dose", "diethylnitrosamine", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "suggest", "that", "C1956039#ent", "<e1>", "plays", "a", "necessary", "role", "in", "the", "stimulation", "of", "C0029282#ent", "<e2>", "activity", "by", "ACTH", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [14, 15]}}
{"token": ["Calu-OE", "(", "8", "folds", ")", "did", "not", "alter", "the", "expression", "levels", "of", "DHPR", ",", "RyR2", ",", "NCX", ",", "C0916183#ent", "<e1>", ",", "CSQ", "and", "C1538915#ent", "<e2>", "."], "h": {"id": "C0916183", "name": "C0916183#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1538915", "name": "C1538915#ent", "pos": [23, 24]}}
{"token": ["The", "protein", "expression", "ryanodine", "receptor", "RyR", ")", ",", "phospho-Ser(2809)-RyR", ",", "sarcoplasmic", "reticulum", "Ca(2+)", "ATPase", "C0916183#ent", "<e1>", ")", ",", "Na(+)/Ca(2+)", "exchanger", "NCX", ")", ",", "phospholamban", "(", "C1538915#ent", "<e2>", ")", ",", "phospho-Ser(16)-PLN", ",", "and", "phospho-Thr(17)-PLN", "were", "analyzed", "by", "Western", "blotting"], "h": {"id": "C0916183", "name": "C0916183#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1538915", "name": "C1538915#ent", "pos": [25, 26]}}
{"token": ["Endoglycosidase", "F", "treatment", "of", "labeled", "C1412246#ent", "<e1>", "results", "in", "a", "single", "labeled", "of", "Mr", "38,000", "without", "intermediate", "C0030956#ent", "<e2>", ",", "suggesting", "a", "single", "N-linked", "carbohydrate", "chain", "."], "h": {"id": "C1412246", "name": "C1412246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}}
{"token": ["It", "also", "is", "not", "clear", "whether", "C0022245#ent", "<e1>", "is", "equally", "effective", "in", "inducing", "C4049859#ent", "<e2>", "in", "the", "clinical", "subtypes", "vagotonic", ",", "adrenergic", ",", "and", "random", "AF"], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [13, 14]}}
{"token": ["However", ",", "no", "studies", "have", "determined", "the", "sensitivity", "and", "specificity", "of", "C0022245#ent", "<e1>", "for", "the", "induction", "of", "C4049859#ent", "<e2>", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "C1420267#ent", "<e1>", "is", "the", "first", "cue", "corrected", "by", "RA", "in", "the", "C1705336#ent", "<e2>", "to", "ensure", "synchronized", "bilateral", "segmentation", "."], "h": {"id": "C1420267", "name": "C1420267#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705336", "name": "C1705336#ent", "pos": [13, 14]}}
{"token": ["In", "the", "hair", "follicle", "C0633227#ent", "<e1>", "mainly", "expressed", "in", "the", "outer", "root", "sheath", "except", "C1136747#ent", "<e2>", "which", "was", "strongly", "expressed", "in", "the", "inner", "root", "sheath"], "h": {"id": "C0633227", "name": "C0633227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1136747", "name": "C1136747#ent", "pos": [14, 15]}}
{"token": ["C0633227#ent", "<e1>", "Prx-I", ")", ",", "a", "key", "member", "of", "the", "C1136747#ent", "<e2>", "reduces", "peroxides", "and", "equivalents", "through", "the", "thioredoxin", "system"], "h": {"id": "C0633227", "name": "C0633227#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1136747", "name": "C1136747#ent", "pos": [10, 11]}}
{"token": ["The", "ability", "of", "ribosomes", "of", "myotube", "extract", "bind", "C1705231#ent", "<e1>", "mRNA", "was", "somewhat", "enhanced", "by", "addition", "of", "C0086376#ent", "<e2>", "derived", "from", "washing", "these", "ribosomes", "with", "a", "high-ionic-strength", "buffer", "."], "h": {"id": "C1705231", "name": "C1705231#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}}
{"token": ["Modeling", "of", "C1705231#ent", "<e1>", "binding", "data", "and", "comparison", "to", "other", "C0086376#ent", "<e2>", "with", "regulatory", "and", "nucleoid-associated", "properties", "suggests", "similar", "mechanisms", "."], "h": {"id": "C1705231", "name": "C1705231#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["No", "similarity", "was", "revealed", "when", "the", "amino", "acid", "sequence", "C1705231#ent", "<e1>", "was", "compared", "with", "other", "C0086376#ent", "<e2>", "whose", "biochemical", "structure", "known", "."], "h": {"id": "C1705231", "name": "C1705231#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["The", "differential", "recognition", "serpin-protease", "complexes", "by", "fibroblasts", "and", "hepatoma", "cells", "however", ",", "indicates", "that", "C1705231#ent", "<e1>", ",", "gp330", ",", "and", "the", "serpin-enzyme", "complex", "receptor", "distinct", "C0086376#ent", "<e2>", "."], "h": {"id": "C1705231", "name": "C1705231#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [25, 26]}}
{"token": ["The", "Wilms'", "tumour", "suppressor", "gene", "encodes", "a", "C1417585#ent", "<e1>", "is", "essential", "for", "the", "development", "of", "kidney", ",", "C0018050#ent", "<e2>", ",", "spleen", "and", "adrenals", "."], "h": {"id": "C1417585", "name": "C1417585#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [17, 18]}}
{"token": ["The", "WT1", "tumor", "suppressor", "gene", "a", "C1417585#ent", "<e1>", "is", "required", "for", "development", "of", "the", "kidney", "and", "C0018050#ent", "<e2>", "."], "h": {"id": "C1417585", "name": "C1417585#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [16, 17]}}
{"token": ["Life", "threatening", "C1457887#ent", "<e1>", "the", "continuation", "of", "C0033497#ent", "<e2>", "until", "the", "bundle", "of", "His", "surgically", "severed", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [7, 8]}}
{"token": ["The", "C1457887#ent", "<e1>", "in", "a", "larger", "extent", "improved", "by", "C0033497#ent", "<e2>", "than", "by", "Nifedipin", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}}
{"token": ["In", "logistic", "regression", "analysis", "carriage", "of", "A", "C1706112#ent", "<e1>", "retained", "a", "significant", "association", "with", "C0022660#ent", "<e2>"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [14, 15]}}
{"token": ["It", "has", "recently", "been", "reported", "that", "the", "glucosidase", "I", "inhibitor", "C0068121#ent", "<e1>", "(", "MDJN", ")", ",", "inhibits", "myoblast", "fusion", "the", "mannosidase", "inhibitor", "C0089266#ent", "<e2>", "(", "ManDJN", ")", ",", "has", "no", "effect", "fusion", "."], "h": {"id": "C0068121", "name": "C0068121#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0089266", "name": "C0089266#ent", "pos": [22, 23]}}
{"token": ["We", "know", "of", "no", "previous", "report", "of", "C0032285#ent", "<e1>", "caused", "by", "C0065656#ent", "<e2>", "HCl", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0065656", "name": "C0065656#ent", "pos": [11, 12]}}
{"token": ["Consequently", ",", "it", "was", "observed", "that", "C1824810#ent", "<e1>", "release", "from", "the", "C0085409#ent", "<e2>", "gel", "beads", "highly", "accelerated", "compared", "to", "the", "release", "from", "alginate", "gel", "beads", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085409", "name": "C0085409#ent", "pos": [11, 12]}}
{"token": ["Although", "total", "knockdown", "of", "C1422793#ent", "<e1>", "was", "not", "achieved", ",", "the", "observed", "reduction", "in", "C2348755#ent", "<e2>", "sufficient", "to", "result", "in", "a", "cellular", "phenotype", "of", "reduced", "actin", "stress", "fibers"], "h": {"id": "C1422793", "name": "C1422793#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2348755", "name": "C2348755#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrated", "knockdown", "of", "both", "C1422793#ent", "<e1>", "mRNA", "and", "C2348755#ent", "<e2>"], "h": {"id": "C1422793", "name": "C1422793#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2348755", "name": "C2348755#ent", "pos": [9, 10]}}
{"token": ["Flupirtine", "and", "C0530684#ent", "<e1>", "exerted", "anti-oxidative", "effects", "in", "C3810569#ent", "<e2>", "12", "cultures", "independent", "of", "their", "ability", "to", "prevent", "cell", "death"], "h": {"id": "C0530684", "name": "C0530684#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [8, 9]}}
{"token": ["There", "were", "two", "different", "patterns", "of", "C0724725#ent", "<e1>", "modulation", "of", "GABA(A)", "receptor", "in", "the", "C0014544#ent", "<e2>", "DGCs", "."], "h": {"id": "C0724725", "name": "C0724725#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [14, 15]}}
{"token": ["Their", "C0040416#ent", "<e1>", "reacted", "to", "light", ",", "C0026205#ent", "<e2>", ",", "and", "mydriatics", ",", "but", "reactions", "were", "diminished", "."], "h": {"id": "C0040416", "name": "C0040416#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026205", "name": "C0026205#ent", "pos": [7, 8]}}
{"token": ["The", "average", "visual", "benefit", "for", "normal", "eyes", "16", "c/deg", "is", "approximately", "2.5", "for", "a", "5.7-mm", "C0040416#ent", "<e1>", "and", "is", "negligible", "for", "C0026205#ent", "<e2>", "1.25", "for", "a", "3-mm", "C0040416#ent", "<e1>", ")", "."], "h": {"id": "C0040416", "name": "C0040416#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026205", "name": "C0026205#ent", "pos": [21, 22]}}
{"token": ["Compared", "to", "wt", "C1710337#ent", "<e1>", ",", "the", "P34H", "oxidized", "C1710337#ent", "<e1>", "was", "about", "twice", "as", "good", "a", "substrate", "for", "C3811250#ent", "<e1>", "from", "E.", "coli", "four", "times", "as", "efficient", "with", "calf", "thymus", "C3811250#ent", "<e1>", "."], "h": {"id": "C1710337", "name": "C1710337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811250", "name": "C3811250#ent", "pos": [19, 20]}}
{"token": ["Thrombocytopenia", "is", "much", "more", "common", "during", "C0040560#ent", "<e1>", "the", "rare", "cases", "of", "purpura", "associated", "with", "acquired", "toxoplasmosis", "usually", "not", "C1861185#ent", "<e2>", "."], "h": {"id": "C0040560", "name": "C0040560#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1861185", "name": "C1861185#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", ",", "we", "examined", "the", "effects", "of", "tea", "catechins", "regular", "exercise", "the", "C3536868#ent", "<e1>", "physical", "performance", "senescence-accelerated", "prone", "mice", "(", "C1419254#ent", "<e2>", ")", "and", "age-matched", "senescence-accelerated", "resistant", "mice", "(", "SAMR1", ")", "."], "h": {"id": "C3536868", "name": "C3536868#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419254", "name": "C1419254#ent", "pos": [22, 23]}}
{"token": ["Pseudocholinesterase", "and", "two", "human", "liver", "carboxylesterases", "human", "liver", "carboxylesterase", "1", "(", "C3889388#ent", "<e1>", ")", "and", "human", "liver", "carboxylesterase", "2", "(", "C1258847#ent", "<e2>", ")", "]", "catalyze", "the", "rapid", "hydrolysis", "of", "ester", "linkages", "cocaine", "."], "h": {"id": "C3889388", "name": "C3889388#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [20, 21]}}
{"token": ["Northern", "blot", "hybridization", "analysis", "that", "the", "expression", "of", "C3889388#ent", "<e1>", "is", "restricted", "to", "cells", "of", "the", "C1258847#ent", "<e2>"], "h": {"id": "C3889388", "name": "C3889388#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [16, 17]}}
{"token": ["Human", "carboxylesterase", "1", "hCE-1", ",", "CES1A1", ",", "HU1", ")", "and", "carboxylesterase", "2", "C3889388#ent", "<e1>", ",", "hiCE", ",", "HU3", ")", "are", "a", "C1258847#ent", "<e2>", "in", "both", "drug", "metabolism", "activation", "."], "h": {"id": "C3889388", "name": "C3889388#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [21, 22]}}
{"token": ["The", "circulating", "levels", "of", "both", "AGEs", "and", "C1414260#ent", "<e1>", "have", "been", "reported", "to", "be", "increased", "in", "C1561643#ent", "<e2>"], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [16, 17]}}
{"token": ["DAS", "and", "C1412379#ent", "<e1>", ",", "but", "not", "DAT", "or", "C1412390#ent", "<e2>", ",", "inhibited", "pulmonary", "adenoma", "formation", "."], "h": {"id": "C1412379", "name": "C1412379#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412390", "name": "C1412390#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "was", "to", "investigate", "the", "effects", "of", "C1420120#ent", "<e1>", "glucose", "uptake", "enterocyte", "apoptosis", "and", "barrier", "defects", "induced", "by", "bacterial", "lipopolysaccharide", "C2697656#ent", "<e2>", ")", "."], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [21, 22]}}
{"token": ["Their", "elution", "behavior", "during", "anion-exchange", "column", "chromatography", "similar", "to", "that", "described", "previously", "for", "the", "cytosolic", "(", "C0694872#ent", "<e1>", ")", "and", "chloroplastic", "(", "ICDH2", ")", "enzymes", "from", "C1572795#ent", "<e2>", "(", "Pisum", "sativum", "leaves", "."], "h": {"id": "C0694872", "name": "C0694872#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1572795", "name": "C1572795#ent", "pos": [26, 27]}}
{"token": ["Cells", "treated", "with", "C0012403#ent", "<e1>", "DMSO", ")", "or", "C0062641#ent", "<e2>", "(", "HMBA", ")", "differentiate", "morphologically", "within", "3", "days", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0062641", "name": "C0062641#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "C1708407#ent", "<e1>", "was", "competitively", "antagonized", "(", "C1839259#ent", "<e2>", "=", "0.27", "+", "/-", "0.10", "nM", ")", "by", "a", "selective", "peptide", "antagonist", "of", "the", "V1", "vasopressin", "receptor"], "h": {"id": "C1708407", "name": "C1708407#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [9, 10]}}
{"token": ["Deglycosylation", "of", "C1708407#ent", "<e1>", "in", "Daudi", "cell", "membranes", "results", "in", "a", "70", "C1839259#ent", "<e2>", "C1708407#ent", "<e1>", "species", ",", "indicating", "that", "nearly", "half", "of", "the", "apparent", "molecular", "mass", "Daudi", "cell", "C1708407#ent", "<e1>", "is", "contributed", "by", "carbohydrate", "moieties"], "h": {"id": "C1708407", "name": "C1708407#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [12, 13]}}
{"token": ["C0524938#ent", "<e1>", "the", "appended", "alkynyl", "units", "to", "the", "C0751951#ent", "<e2>", "Stokes", "shifts", "above", "16,000", "cm(-1", ")", "."], "h": {"id": "C0524938", "name": "C0524938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751951", "name": "C0751951#ent", "pos": [8, 9]}}
{"token": ["Reported", "beneficial", "effects", "include", "the", "ability", "to", "control", "excessive", "erythrocytosis", "and", "C3277671#ent", "<e1>", "and", "such", "disease-related", "features", "as", "C0750152#ent", "<e2>", "pruritus", ",", "and", "splenomegaly", "."], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0750152", "name": "C0750152#ent", "pos": [18, 19]}}
{"token": ["Essential", "thrombocythemia", "ET", ")", "is", "a", "chronic", "myeloid", "disorder", "is", "characterized", "by", "C3277671#ent", "<e1>", ",", "thrombohemorrhagic", "and", "C0750152#ent", "<e2>", "a", "long", "median", "survival", "and", "a", "low", "risk", "transformation", "to", "leukemia", "."], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0750152", "name": "C0750152#ent", "pos": [17, 18]}}
{"token": ["Sulfonamide", "carbonic", "anhydrase", "CA", ")", "inhibitors", "are", "widely", "employed", "in", "the", "diagnosis", "and", "treatment", "of", "diverse", "diseases", "such", "as", "C0017601#ent", "<e1>", "and", "different", "C0751950#ent", "<e2>"], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [23, 24]}}
{"token": ["C0020402#ent", "<e1>", "(", "HU", ")", "is", "a", "good-controllable", "and", "well-tolerated", "C0010858#ent", "<e2>"], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [10, 11]}}
{"token": ["C0020402#ent", "<e1>", "is", "a", "C0010858#ent", "<e2>", "to", "treat", "myeloproliferative", "disorders", "long-term", "treatment", "is", "associated", "with", "mucocutaneous", "adverse", "events", "nail", "hyperpigmentation"], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [4, 5]}}
{"token": ["C0020402#ent", "<e1>", "is", "one", "of", "several", "C0010858#ent", "<e2>", "have", "been", "shown", "to", "increase", "the", "production", "of", "fetal", "hemoglobin", "some", "patients", "with", "sickle", "cell", "disease"], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [6, 7]}}
{"token": ["C1709138#ent", "<e1>", "levels", "in", "controls", "(", "exposed", "to", "C1414404#ent", "<e2>", "alone", ",", "or", "dosed", "with", "morpholine", "without", "subsequent", "C1414404#ent", "<e2>", "exposure", ")", "were", "less", "than", "5", "ng/mouse", "."], "h": {"id": "C1709138", "name": "C1709138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414404", "name": "C1414404#ent", "pos": [8, 9]}}
{"token": ["Reintroduction", "of", "C0033036#ent", "<e1>", "removed", "beta-catenin", "from", "C1420644#ent", "<e2>", "and", "abrogated", "the", "transcriptional", "transactivation"], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420644", "name": "C1420644#ent", "pos": [7, 8]}}
{"token": ["One", "of", "the", "biochemical", "activities", "associated", "with", "C0033036#ent", "<e1>", "down-regulation", "of", "transcriptional", "activation", "by", "beta-catenin", "and", "T", "cell", "transcription", "factor", "4", "C1420644#ent", "<e2>", ")", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420644", "name": "C1420644#ent", "pos": [21, 22]}}
{"token": ["Infection", ",", "drugs", ",", "malignancy", ",", "C0002888#ent", "<e1>", ",", "hypersplenism", "and", "C0027947#ent", "<e2>", "are", "responsible", "for", "most", "cases", "of", "neutropenia", "."], "h": {"id": "C0002888", "name": "C0002888#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [11, 12]}}
{"token": ["Hematological", "manifestations", "MID", "include", "aplastic", ",", "C0002888#ent", "<e1>", ",", "or", "sideroblastic", "anemia", "leukopenia", ",", "C0027947#ent", "<e2>", ",", "thrombocytopenia", ",", "or", "pancytopenia", "."], "h": {"id": "C0002888", "name": "C0002888#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [14, 15]}}
{"token": ["Hemoperitoneum", "secondary", "to", "rupture", "of", "the", "corpus", "luteum", "be", "considered", "in", "the", "differential", "diagnosis", "C0000737#ent", "<e1>", "women", "with", "congenital", "and", "acquired", "coagulation", "C0268487#ent", "<e2>", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [22, 23]}}
{"token": ["Sympathetic", "denervation", "hypersensitivity", "of", "the", "C1256254#ent", "<e1>", "was", "assessed", "in", "51", "patients", "with", "C0028840#ent", "<e2>", "36", "age-", "and", "sex-matched", "control", "subjects"], "h": {"id": "C1256254", "name": "C1256254#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028840", "name": "C0028840#ent", "pos": [13, 14]}}
{"token": ["C0267841#ent", "<e1>", "a", "virulent", "disease", "uncertain", "etiology", "observed", "most", "commonly", "in", "C0010340#ent", "<e2>", "patients", "."], "h": {"id": "C0267841", "name": "C0267841#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010340", "name": "C0010340#ent", "pos": [11, 12]}}
{"token": ["In", "both", "liver", "and", "pancreatic", "islet", "C1415014#ent", "<e1>", "is", "allosterically", "regulated", "by", "an", "inhibitory", "protein", "glucokinase", "regulatory", "protein", "C1417021#ent", "<e2>", ")", "."], "h": {"id": "C1415014", "name": "C1415014#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417021", "name": "C1417021#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "indicate", "that", "the", "Rho", "signaling", "pathway", "primarily", "through", "C0389995#ent", "<e1>", ",", "plays", "a", "crucial", "role", "in", "survival", "of", "C3810599#ent", "<e2>", "embryogenesis", ",", "particularly", "at", "the", "early", "developmental", "stages"], "h": {"id": "C0389995", "name": "C0389995#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3810599", "name": "C3810599#ent", "pos": [20, 21]}}
{"token": ["We", "have", "previously", "characterized", "a", "truncation", "mutant", "the", "erythropoietin", "receptor", "C1333342#ent", "<e1>", ")", ",", "which", "is", "associated", "with", "C0152264#ent", "<e2>", "Blood", "89:4628", ",", "1997", ")", "."], "h": {"id": "C1333342", "name": "C1333342#ent", "pos": [10, 11]}, "relation": "gene_associated_with_disease", "t": {"id": "C0152264", "name": "C0152264#ent", "pos": [18, 19]}}
{"token": ["The", "measurement", "of", "urinary", "C1704716#ent", "<e1>", "would", "be", "useful", "for", "predicting", "long-term", "changes", "in", "C1414083#ent", "<e2>", "at", "radial", "and", "lumbar", "spine", "PTX", "than", "other", "bone", "metabolic", "indices", "."], "h": {"id": "C1704716", "name": "C1704716#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [14, 15]}}
{"token": ["Urine", "C1704716#ent", "<e1>", "tests", "to", "substitute", "for", "C1414083#ent", "<e2>", "measurements", "in", "routine", "health", "examination", "for", "Chinese", "is", "not", "recommended", "."], "h": {"id": "C1704716", "name": "C1704716#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [7, 8]}}
{"token": ["Total", "C1704716#ent", "<e1>", "is", "good", "predictor", "of", "change", "bone", "mineral", "density", "C1414083#ent", "<e2>", ")", "in", "bone", "antiresorptive", "drugs", ",", "however", ",", "free", "C1704716#ent", "<e1>", "is", "inferior", "to", "type", "I", "N-telopeptide", "(", "NTX", ")", "."], "h": {"id": "C1704716", "name": "C1704716#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [11, 12]}}
{"token": ["Analysis", "using", "sucrose", "density", "gradient", "centrifugation", "that", "C1420498#ent", "<e1>", "binding", "to", "CD77", "induced", "recruitment", "and", "activation", "of", "C1442804#ent", "<e2>", "in", "the", "glycolipid-enriched", "membrane", "(", "GEM", ")", "fractions", "."], "h": {"id": "C1420498", "name": "C1420498#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [17, 18]}}
{"token": ["However", ",", "the", "mechanism", "of", "C0812246#ent", "<e1>", "mediated", "activation", "of", "extracellular", "signal-regulated", "kinase", "C0211705#ent", "<e2>", "has", "not", "been", "established", "clearly", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [13, 14]}}
{"token": ["The", "stimulatory", "effect", "was", "greater", "for", "a", "C1335440#ent", "<e1>", "that", "had", "four", "characteristics", "similar", "to", "those", "observed", "with", "C0035680#ent", "<e2>", "other", "organisms", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [18, 19]}}
{"token": ["The", "primary", "target", "of", "juglone", "has", "not", "been", "unambiguously", "identified", ",", "although", "a", "site", "on", "the", "C1335440#ent", "<e1>", "itself", "is", "suggested", "by", "inhibition", "of", "C0035680#ent", "<e2>", "factor-independent", "transcription", "single-stranded", "DNA"], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "underscore", "the", "importance", "of", "colocalization", "of", "PGHS", "and", "C1419071#ent", "<e1>", "to", "ER", "and", "NE", "in", "C0072259#ent", "<e2>"], "h": {"id": "C1419071", "name": "C1419071#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0072259", "name": "C0072259#ent", "pos": [17, 18]}}
{"token": ["The", "P450s", "of", "the", "CYP7", "and", "C1419071#ent", "<e1>", "families", ",", "except", "for", "C0072259#ent", "<e2>", "(", "prostacyclin", "synthase", ",", "catalyze", "the", "oxygenation", "of", "sterols", "from", "an", "alpha", "surface", "in", "the", "middle", "of", "the", "steroid", "skeleton"], "h": {"id": "C1419071", "name": "C1419071#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0072259", "name": "C0072259#ent", "pos": [12, 13]}}
{"token": ["No", "significant", "in", "C3853562#ent", "<e1>", "and", "GSK-3beta", "mRNA", "levels", ",", "GSK-3beta", "protein", "or", "total", "C0244989#ent", "<e2>", "(", "alpha+beta", ")", "activity", "were", "found", "in", "the", "frontal", "cortex", "the", "two", "diagnostic", "groups"], "h": {"id": "C3853562", "name": "C3853562#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0244989", "name": "C0244989#ent", "pos": [14, 15]}}
{"token": ["An", "C0014442#ent", "<e1>", "has", "been", "purified", "to", "homogeneity", "from", "barley", "seedlings", "has", ";", "C0055570#ent", "<e2>", "and", "the", "pyrroline-5-carboxylic", "acid", "reductase", "activities", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0055570", "name": "C0055570#ent", "pos": [13, 14]}}
{"token": ["Notch", "mutants", "with", "a", "strong", "morphological", "expression", "show", "low", "C0014442#ent", "<e1>", "activities", "for", "dihydroorotate", "dehydrogenase", "C0055570#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0055570", "name": "C0055570#ent", "pos": [15, 16]}}
{"token": ["In", "a", "second", "test", ",", "which", "required", "mice", "to", "passively", "avoid", "a", "dark", "chamber", "after", "shock", ",", "C0016293#ent", "<e1>", "pretreatment", "prevented", "the", "occurrence", "of", "amnesia", "induced", "by", "the", "C0242889#ent", "<e2>", "scopolamine", "."], "h": {"id": "C0016293", "name": "C0016293#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [28, 29]}}
{"token": ["C3813124#ent", "<e1>", "is", "a", "52-amino-acid", "C0030956#ent", "<e2>", "synthesized", "as", "part", "of", "a", "185-amino-acid", "preprohormone", "that", "also", "contains", "20-amino-acid", "residues", "in", "the", "N-terminus", ",", "which", "has", "similar", "biological", "activity"], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}}
{"token": ["C3813124#ent", "<e1>", "antisense", "oligonucleotide", "treatment", "significantly", "lowered", "C0030956#ent", "<e2>", "content", "in", "the", "hypothalamic", "paraventricular", "PVN", ")", "nucleus", "and", "exaggerated", "the", "consumption", "of", "sodium", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}}
{"token": ["Adrenomedullin", "(", "C3813124#ent", "<e1>", ")", "is", "a", "newly", "discovered", "C0030956#ent", "<e2>", "that", "has", "a", "potent", "vasorelaxant", "activity", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}}
{"token": ["Strenuous", "exercise", "exacerbates", "C0017168#ent", "<e1>", "symptoms", "and", "this", "may", "be", "diminished", "by", "antisecretory", "medication", "C0028978#ent", "<e2>", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [14, 15]}}
{"token": ["The", "C1332077#ent", "<e1>", "concentration", "of", "MPO", "was", "significantly", "higher", "in", "patients", "with", "C1647218#ent", "<e2>", "compared", "with", "asthma", "patients", "."], "h": {"id": "C1332077", "name": "C1332077#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [12, 13]}}
{"token": ["Small", "interfering", "RNA", "siRNA", ")", "against", "C3890603#ent", "<e1>", ",", "a", "protein", "linker", "ZW10", "and", "the", "C1414461#ent", "<e2>", "soluble", "N-ethylmaleimide-sensitive", "factor", "attachment", "protein", "receptor", "syntaxin", "18", ",", "produced", "similar", "Golgi", "disruption"], "h": {"id": "C3890603", "name": "C3890603#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [15, 16]}}
{"token": ["When", "applied", "to", "the", "samples", "from", "positive", "patients", ",", "the", "method", "clearly", "differentiated", "normal", "subjects", "from", "the", "patients", "with", "various", "C0025517#ent", "<e1>", "as", "PKU", ",", "MSUD", ",", "C0013231#ent", "<e2>", "and", "a", "Propionic", "Aciduria"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0013231", "name": "C0013231#ent", "pos": [27, 28]}}
{"token": ["Since", "PP11", "has", "serine", "protease", "activity", ",", "it", "is", "predicted", "that", "its", "C1334043#ent", "<e1>", "PPSB", ",", "may", "function", "as", "a", "C0920330#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0920330", "name": "C0920330#ent", "pos": [20, 21]}}
{"token": ["C0037285#ent", "<e1>", "such", "as", "melanosis", "and", "C0870082#ent", "<e2>", ",", "were", "the", "common", "symptoms", "of", "arsenicosis", "."], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0870082", "name": "C0870082#ent", "pos": [6, 7]}}
{"token": ["We", "also", "consider", "the", "product", "suitable", "for", "therapeutic", "use", "in", "general", "practice", "to", "clinical", "treatment", "since", ",", "in", "compliance", "with", "the", "appropriate", "definition", ",", "C0010200#ent", "<e1>", "represents", "the", "main", "symptom", "of", "C0008677#ent", "<e2>"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [24, 25]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [31, 32]}}
{"token": ["Microscopic", "detection", "of", "budding", "and", "branching", ",", "myceliform", "fungi", "in", "the", "secret", "produced", "by", "C0010200#ent", "<e1>", "supports", "the", "diagnosis", "of", "mould", "causing", "C0008677#ent", "<e2>"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [22, 23]}}
{"token": ["The", "purpose", "of", "this", "review", "is", "to", "present", "the", "evidence", "for", "the", "diagnosis", "and", "treatment", "of", "C0010200#ent", "<e1>", "due", "to", "C0008677#ent", "<e2>", "and", "to", "make", "recommendations", "that", "will", "be", "useful", "for", "clinical", "practice"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [20, 21]}}
{"token": ["Histamine", "H(1)", "receptor", "antagonists", "such", "as", "cetirizine", "and", "C0772294#ent", "<e1>", "significantly", "inhibited", "antigen-induced", "nasal", "allergic", "in", "C2987364#ent", "<e2>", "although", "the", "effects", "were", "incomplete", "."], "h": {"id": "C0772294", "name": "C0772294#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [16, 17]}}
{"token": ["The", "number", "of", "eosinophils", "in", "the", "nasal", "mucosa", "significantly", "decreased", "by", "cetirizine", "and", "C0772294#ent", "<e1>", ",", "ramatroban", "and", "zafirlukast", "in", "C2987364#ent", "<e2>"], "h": {"id": "C0772294", "name": "C0772294#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "obesity", "and", "overweight", "are", "very", "prevalent", "in", "C1540056#ent", "<e1>", "migrant", "children", "and", "undernutrition", ",", "especially", "C0235394#ent", "<e2>", ",", "was", "also", "not", "uncommon", "in", "this", "target", "group", "."], "h": {"id": "C1540056", "name": "C1540056#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0235394", "name": "C0235394#ent", "pos": [18, 19]}}
{"token": ["The", "activation", "by", "C0282211#ent", "<e1>", "of", "phospholipid", "methyltransferase", "abolished", "by", "the", "beta-blocker", "C0033497#ent", "<e2>", "and", "by", "insulin", "."], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [12, 13]}}
{"token": ["C0586989#ent", "<e1>", "VZV", ")", ",", "the", "cause", "of", "chicken", "pox", "establishes", "C1321909#ent", "<e2>", "sensory", "ganglia"], "h": {"id": "C0586989", "name": "C0586989#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1321909", "name": "C1321909#ent", "pos": [11, 12]}}
{"token": ["The", "molecular", "mechanisms", "which", "C0586989#ent", "<e1>", "VZV", ")", "causes", "a", "C1321909#ent", "<e2>", "human", "trigeminal", "and", "spinal", "ganglia", "not", "well", "understood", "."], "h": {"id": "C0586989", "name": "C0586989#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1321909", "name": "C1321909#ent", "pos": [10, 11]}}
{"token": ["This", "review", "highlights", "the", "alphaherpesvirus", ",", "specifically", "herpes", "simplex", "virus", "type", "1", "C0586989#ent", "<e1>", "and", "describes", "the", "characteristics", "of", "C1321909#ent", "<e2>"], "h": {"id": "C0586989", "name": "C0586989#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1321909", "name": "C1321909#ent", "pos": [19, 20]}}
{"token": ["We", "found", "that", "C2985257#ent", "<e1>", "physically", "interacts", "with", "c-Jun", ",", "JunB", ",", "and", "C0087140#ent", "<e2>", "and", "inhibits", "AP-1", "transcriptional", "activity", "."], "h": {"id": "C2985257", "name": "C2985257#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [13, 14]}}
{"token": ["The", "results", "indicate", "that", "C2985257#ent", "<e1>", "overexpression", "causes", "B-CLL", "by", "directly", "enhancing", "NF-kappaB", "activity", "inhibiting", "C0087140#ent", "<e2>", "."], "h": {"id": "C2985257", "name": "C2985257#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [15, 16]}}
{"token": ["We", "tested", "whether", "dopamine", ",", "C3887648#ent", "<e1>", ",", "and", "serotonin", "function", "dysregulated", "in", "C1825952#ent", "<e2>", "ko", "and", "wild-type", "(", "wt", ")", "mice", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1825952", "name": "C1825952#ent", "pos": [13, 14]}}
{"token": ["Biochemical", "in", "vitro", "studies", "revealed", "that", "C1416374#ent", "<e1>", "bound", "to", "C1427865#ent", "<e2>", "but", "not", "to", "ZO-1", ",", "whereas", "JAM1", "did", "not", "bind", "to", "C1427865#ent", "<e2>", "."], "h": {"id": "C1416374", "name": "C1416374#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1427865", "name": "C1427865#ent", "pos": [10, 11]}}
{"token": ["The", "present", "study", "was", "designed", "to", "explore", "the", "effect", "of", "8-CA", "on", "3", "kinds", "of", "enzyme", "activities", "chymotrypsin-like", "activity", "trypsin-like", "activity", "and", "peptidyl-glutamyl-", "peptide", "C0054741#ent", "<e1>", "activity", ")", "of", "C0208355#ent", "<e2>", "human", "progranulocyte", "leukemia", "HL-60", "cells"], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0208355", "name": "C0208355#ent", "pos": [29, 30]}}
{"token": ["Several", "other", "regulators", "(", "sarR", ",", "sarV", ",", "C1419818#ent", "<e1>", ",", "sae", ")", "that", "may", "impact", "C1947941#ent", "<e2>", "expression", "have", "been", "described", "."], "h": {"id": "C1419818", "name": "C1419818#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [16, 17]}}
{"token": ["The", "severe", "acute", "respiratory", "syndrome", "C1419818#ent", "<e1>", ")", "coronavirus", "(", "CoV", ")", "main", "C1947941#ent", "<e2>", "represents", "an", "attractive", "target", "for", "the", "development", "of", "novel", "anti-SARS", "agents", "."], "h": {"id": "C1419818", "name": "C1419818#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [13, 14]}}
{"token": ["The", "highly", "conserved", "C-terminal", "domain", "C1707839#ent", "<e1>", "interacts", "with", "C2697539#ent", "<e2>", "in", "vitro", "and", "Tup1-Ssn6", "complexes", "co-purify", "with", "the", "Cet1", "protein", ",", "indicating", "that", "in", "vivo", "interactions", "also", "occur", "between", "these", "proteins", "."], "h": {"id": "C1707839", "name": "C1707839#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697539", "name": "C2697539#ent", "pos": [9, 10]}}
{"token": ["Both", "of", "the", "SH2", "domains", "the", "SH3", "domain", "C1423078#ent", "<e1>", "also", "formed", "complexes", "with", "C1565427#ent", "<e2>", "in", "vitro"], "h": {"id": "C1423078", "name": "C1423078#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [14, 15]}}
{"token": ["A", "42-nucleotide", "intercistronic", "region", "separates", "C1427622#ent", "<e1>", "from", "a", "second", ",", "shorter", "C0079941#ent", "<e2>", "ORF2", ")", "located", "near", "the", "3'-end", "of", "the", "RNA", "."], "h": {"id": "C1427622", "name": "C1427622#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [12, 13]}}
{"token": ["This", "plasmid", "consisted", "of", "1446", "bp", "and", "could", "encode", "a", "putative", "polypeptide", "152", "amino", "acid", "residues", "(", "C1427622#ent", "<e1>", ")", "in", "an", "C0079941#ent", "<e2>"], "h": {"id": "C1427622", "name": "C1427622#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [22, 23]}}
{"token": ["A", "BlastX", "search", "found", "similarities", "for", "two", "diet-upregulated", "clones", ",", "i.e.", ",", "the", "C0041491#ent", "<e1>", "the", "gene", "for", "the", "chitin", "binding", "protein", "C2677838#ent", "<e2>", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2677838", "name": "C2677838#ent", "pos": [22, 23]}}
{"token": ["Ultrasonographic", "examination", "the", "liver", "and", "biliary", "system", "a", "portable", "ultrasound", "unit", "performed", "in", "1987", "in", "647", "C0029106#ent", "<e1>", "patients", "who", "had", "been", "treated", "with", "C0032911#ent", "<e2>", "during", "1981", "to", "1986", "."], "h": {"id": "C0029106", "name": "C0029106#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [24, 25]}}
{"token": ["We", "present", "a", "case", "of", "a", "young", "woman", "with", "a", "previous", "history", "of", "C0020473#ent", "<e1>", "developed", "hypertriglyceridemia", "and", "pancreatitis", "after", "initiation", "of", "C0022265#ent", "<e2>"], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [22, 23]}}
{"token": ["Administration", "icv", "of", "300", "ng", "of", "C1705056#ent", "<e1>", "failed", "to", "produce", "behavioral", "activation", "and", "tachycardia", "in", "C1414571#ent", "<e2>", "rats", "."], "h": {"id": "C1705056", "name": "C1705056#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414571", "name": "C1414571#ent", "pos": [16, 17]}}
{"token": ["We", "report", "a", "familial", "case", "C2675711#ent", "<e1>", "DUH", ")", "which", "is", "compatible", "with", "an", "C2936739#ent", "<e2>", "inheritance", "."], "h": {"id": "C2675711", "name": "C2675711#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [14, 15]}}
{"token": ["The", "39-kDa", "receptor-associated", "protein", "C1416920#ent", "<e1>", ")", "is", "cosynthesized", "and", "co-purifies", "with", "the", "C1416914#ent", "<e2>", "is", "thought", "to", "modulate", "ligand", "binding", "LRP", "."], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416914", "name": "C1416914#ent", "pos": [13, 14]}}
{"token": ["Receptor-associated", "protein", "C1416920#ent", "<e1>", ")", "is", "a", "molecular", "chaperone", "C1416914#ent", "<e2>", "LRP", ")", ",", "which", "plays", "a", "key", "role", "in", "cholesterol", "metabolism"], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416914", "name": "C1416914#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "C1416920#ent", "<e1>", "binds", "another", "putative", "receptor", "the", "kidney", "glycoprotein", "330", "C1416914#ent", "<e2>", ")", "."], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416914", "name": "C1416914#ent", "pos": [14, 15]}}
{"token": ["These", "data", "demonstrate", "that", "C2936882#ent", "<e1>", "alters", "the", "levels", "of", "C1420180#ent", "<e2>", "and", "synaptic", "vesicle", "zinc", "in", "female", "mice", ",", "probably", "through", "changing", "AP-3", "delta", "expression", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420180", "name": "C1420180#ent", "pos": [10, 11]}}
{"token": ["Oxaprozin", ",", "an", "anti-inflammatory", "agent", "a", "half-life", "of", "50", "hours", ",", "was", "compared", "in", "regard", "to", "efficacy", "and", "tolerance", "with", "C0038792#ent", "<e1>", "in", "a", "12-week", "double-blind", "parallel", "treatment", "trial", "of", "C0038013#ent", "<e2>"], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [30, 31]}}
{"token": ["By", "using", "partially", "purified", "C1955880#ent", "<e1>", "human", "immunodeficiency", "virus", "type", "1", "human", "cytomegalovirus", "DNA", "polymerase", "various", "combinations", "of", "3'-azido-3'-deoxythymidine-5'-triphosphate", "and", "C0376236#ent", "<e2>", "produced", "strong", "indications", "of", "additive", "interactions", "."], "h": {"id": "C1955880", "name": "C1955880#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0376236", "name": "C0376236#ent", "pos": [20, 21]}}
{"token": ["C1955880#ent", "<e1>", "inhibited", "by", "C0376236#ent", "<e2>", ",", "ribavirin", "5'-triphosphate", "ddATP", ",", "ddCTP", ",", "ddGTP", ",", "and", "ddTTP", "."], "h": {"id": "C1955880", "name": "C1955880#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0376236", "name": "C0376236#ent", "pos": [4, 5]}}
{"token": ["One", "of", "these", "bands", "corresponds", "to", "C1334064#ent", "<e1>", "a", "nonspecific", "C1257646#ent", "<e2>", "known", "to", "contain", "one", "free", "sulfhydryl", "group", "previously", "shown", "to", "be", "a", "target", "protein", "for", "[14C]BB", "metabolites", "."], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [10, 11]}}
{"token": ["This", "study", "targets", "another", "kind", "of", "C1334064#ent", "<e1>", ",", "carboxylic", "esterase", "with", "the", "objectives", "of", "identifying", "C1257646#ent", "<e2>", "determining", "whether", "it", "is", "a", "protective", "antigen"], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [16, 17]}}
{"token": ["In", "this", "communication", "we", "show", "that", "C1334064#ent", "<e1>", "activity", "in", "the", "uterus", "results", "from", "uptake", "of", "an", "C1257646#ent", "<e2>", "from", "the", "blood", "."], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [17, 18]}}
{"token": ["C0009186#ent", "<e1>", "may", "be", "effectively", "treated", "with", "prolonged", "and", "sometimes", "life-long", "C0064113#ent", "<e2>", "or", "fluconazole", "therapy", "."], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [11, 12]}}
{"token": ["N200", "and", "C1705458#ent", "<e1>", "of", "event-related", "potentials", "ERPs", ")", "were", "recorded", "from", "22", "C0234533#ent", "<e2>", "children", "receiving", "high-dose", "antiepileptic", "drugs", "."], "h": {"id": "C1705458", "name": "C1705458#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [13, 14]}}
{"token": ["C1112709#ent", "<e1>", "was", "defined", "by", "the", "presence", "of", "at", "least", "four", "C0064833#ent", "<e2>", "microscopic", "field", "x1,000", "magnification", ")", "on", "a", "smear", "in", "which", "Neisseria", "gonorrhoeae", "not", "be", "detected", "."], "h": {"id": "C1112709", "name": "C1112709#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [11, 12]}}
{"token": ["Most", "patients", "with", "C0221406#ent", "<e1>", "increased", "plasma", "ACTH", "and", "cortisol", "responses", "C1705056#ent", "<e2>", ",", "while", "patients", "with", "the", "ectopic", "ACTH", "syndrome", "not", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705056", "name": "C1705056#ent", "pos": [11, 12]}}
{"token": ["In", "all", "postoperative", "patients", "with", "C0221406#ent", "<e1>", "except", "one", ",", "clear", "ACTH", "and", "cortisol", "responses", "after", "C1705056#ent", "<e2>", ",", "demonstrating", "hypothalamic", "adrenal", "failure", "these", "patients", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705056", "name": "C1705056#ent", "pos": [16, 17]}}
{"token": ["Quinolone", "affinity", "for", "both", "HSA", "and", "C4283942#ent", "<e1>", "was", "already", "demonstrated", "poorly", "related", "to", "C0054616#ent", "<e2>", "lipophilicity", "values", ",", "probably", "due", "to", "the", "occurrence", "of", "electrostatic", "interactions", "."], "h": {"id": "C4283942", "name": "C4283942#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054616", "name": "C0054616#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "study", ",", "eye", "movements", "recorded", "in", "two", "patient", "groups", "an", "autosomal", "dominantly", "inherited", "cerebellar", "disorder", "i.e.", "spinocerebellar", "ataxia", "type", "6", "C1413049#ent", "<e1>", ")", "and", "familial", "cortical", "myoclonic", "tremor", "with", "C0014544#ent", "<e2>", "(", "FCMTE", ")", "."], "h": {"id": "C1413049", "name": "C1413049#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [32, 33]}}
{"token": ["Voltage-dependent", "calcium", "channel", "mutations", "have", "been", "associated", "with", "spinocerebellar", "ataxia", "humans", "(", "C1413049#ent", "<e1>", ")", "and", "with", "ataxia", ",", "progressive", "cerebellar", "degeneration", "and", "C0014544#ent", "<e2>", "in", "mice", "(", "tottering", ",", "lethargic", ",", "and", "stargazer", ")", "."], "h": {"id": "C1413049", "name": "C1413049#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [23, 24]}}
{"token": ["By", "contrast", ",", "another", "form", "of", "human", "C0017921#ent", "<e1>", "--", "transgenic", "enzyme", "C0907533#ent", "<e2>", "produced", "in", "liver", "and", "secreted", "into", "the", "bloodstream", "of", "knockout", "mice", "prevented", "both", "cardiac", "and", "skeletal", "muscle", "glycogen", "accumulation", "."], "h": {"id": "C0017921", "name": "C0017921#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [12, 13]}}
{"token": ["Neither", "of", "the", "two", "reverse", "constructs", ",", "ROS", "x", "C0080298#ent", "<e1>", "ROS", "x", "SRC", "C3273406#ent", "<e2>", ",", "could", "transform", "CEF", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "demonstrate", "that", "C0080298#ent", "<e1>", "phosphorylation", "and", "Src-dependent", "ERK1/2", "signaling", "by", "C3273406#ent", "<e2>", "increased", "in", "VSMCs", "from", "SHR", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [12, 13]}}
{"token": ["The", "alpha/beta", "T", "cell", "receptor", "complex", "signals", "from", "MHC/peptide", "antigens", "through", "a", "set", "of", "C0669365#ent", "<e1>", "associated", "signaling", "molecules", "including", "CD3-epsilon/gamma", "and", "C1332711#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332711", "name": "C1332711#ent", "pos": [22, 23]}}
{"token": ["Thus", "C1414071#ent", "<e1>", "may", "play", "a", "role", "in", "lateral", "inhibition", "to", "that", "of", "C3815532#ent", "<e2>", "and", "Jag2", "."], "h": {"id": "C1414071", "name": "C1414071#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3815532", "name": "C3815532#ent", "pos": [13, 14]}}
{"token": ["C3539606#ent", "<e1>", "is", "a", "main", "regulator", "of", "anti-carcinogenic", "activities", "C0022265#ent", "<e2>", "may", "become", "a", "novel", "diagnostic", "marker", "experimental", "therapeutic", "tool", "prostate", "cancer"], "h": {"id": "C3539606", "name": "C3539606#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [9, 10]}}
{"token": ["Antibodies", "against", "L5", "-", "30", "Mos", "proteins", "detected", "MosB", "and", "C0072454#ent", "<e1>", "Rm220", "-", "3-induced", "nodules", "but", "no", "translation", "product", "either", "C3273411#ent", "<e2>", "or", "mosA", "was", "detected", "."], "h": {"id": "C0072454", "name": "C0072454#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273411", "name": "C3273411#ent", "pos": [21, 22]}}
{"token": ["Transient", "expression", "of", "C1415506#ent", "<e1>", "induced", "both", "VEGF", "C0079429#ent", "<e2>", "and", "protein", "expression", "demonstrated", "by", "a", "reporter", "assay", "VEGF", "gene", "promoter"], "h": {"id": "C1415506", "name": "C1415506#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}}
{"token": ["Focusing", "on", "neurotrophin-3", "(", "C1706578#ent", "<e1>", ")", "and", "its", "high-affinity-receptor", "[", "C1421249#ent", "<e2>", "TrkC", ")", "]", ",", "we", "show", "that", "hair", "placode", "keratinocytes", "TrkC", "mRNA", "and", "immunoreactivity", "early", "during", "murine", "hair", "follicle", "morphogenesis", "."], "h": {"id": "C1706578", "name": "C1706578#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [11, 12]}}
{"token": ["We", "have", "evaluated", "changes", "in", "the", "expression", "of", "neurotrophin-3", "(", "C1706578#ent", "<e1>", ")", "and", "its", "C1421249#ent", "<e2>", "TrkC", ")", "receptor", "in", "the", "neuromuscular", "system", "a", "result", "of", "voluntary", "physical", "activity"], "h": {"id": "C1706578", "name": "C1706578#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [15, 16]}}
{"token": ["BU", "Cp", "(", "P", "=", "0.06", ")", "or", "marrow", "cell", "dose", "P", "=", "0.32", ")", "was", "not", "different", "in", "C0086795#ent", "<e1>", "to", "other", "C0268263#ent", "<e2>", "."], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [19, 20]}, "relation": "manifestation_of", "t": {"id": "C0268263", "name": "C0268263#ent", "pos": [23, 24]}}
{"token": ["There", "was", "no", "difference", "in", "early", "and", "late", "engraftment", "between", "children", "with", "C0086795#ent", "<e1>", "and", "other", "C0268263#ent", "<e2>", "."], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0268263", "name": "C0268263#ent", "pos": [16, 17]}}
{"token": ["Our", "findings", "indicate", "that", "in", "RA", "SFs", "overexpression", "of", "C1425182#ent", "<e1>", "can", "alter", "the", "SUMO-1-mediated", "recruitment", "of", "C1333203#ent", "<e2>", "to", "PML", "NBs", ",", "thus", "influencing", "the", "proapoptotic", "effects", "of", "C1333203#ent", "<e2>", "."], "h": {"id": "C1425182", "name": "C1425182#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333203", "name": "C1333203#ent", "pos": [17, 18]}}
{"token": ["Sequence", "similarities", "between", "C0218144#ent", "<e1>", "and", "C3495143#ent", "<e2>", "and", "magainins", "suggest", "that", "C0218144#ent", "<e1>", "may", "act", "as", "an", "amphipathic", "alpha", "helix"], "h": {"id": "C3495143", "name": "C3495143#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0218144", "name": "C0218144#ent", "pos": [3, 4]}}
{"token": ["Little", "research", "has", "been", "done", "to", "examine", "whether", "C0017040#ent", "<e1>", "(", "GGT", ")", "is", "prospectively", "associated", "with", "development", "of", "C1561643#ent", "<e2>", "CKD", ")", "."], "h": {"id": "C0017040", "name": "C0017040#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [19, 20]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "compare", "prospectively", "somatostatin", "receptor", "scintigraphy", "C0796160#ent", "<e1>", ")", "using", "111n-pentetreotide", "with", "bone", "scintigraphy", "99mTc-hydroxymethylene", "C0012544#ent", "<e2>", "for", "the", "detection", "of", "bone", "metastases"], "h": {"id": "C0796160", "name": "C0796160#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [21, 22]}}
{"token": ["This", "is", "consistent", "with", "function", "for", "Desnutrin/ATGL", ",", "C1538687#ent", "<e1>", ",", "and", "GS2-Like", "in", "lipolysis", ",", "but", "not", "for", "C1540191#ent", "<e2>", "."], "h": {"id": "C1538687", "name": "C1538687#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1540191", "name": "C1540191#ent", "pos": [19, 20]}}
{"token": ["Secretion", "of", "C0054869#ent", "<e1>", "the", "precursor", "of", "a", "C2717970#ent", "<e2>", "has", "been", "described", "for", "ras-transfected", "mouse", "fibroblasts", "and", "several", "human", "cancer", "cell", "lines"], "h": {"id": "C0054869", "name": "C0054869#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [8, 9]}}
{"token": ["The", "framework", "for", "the", "model", "of", "C0054869#ent", "<e1>", "of", "structurally", "conserved", "regions", "from", "tertiary", "structures", "three", "C2717970#ent", "<e2>"], "h": {"id": "C0054869", "name": "C0054869#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [16, 17]}}
{"token": ["SMN(Y272C", ")", ",", "which", "carries", "a", "missense", "mutation", "was", "found", "in", "an", "C0026847#ent", "<e1>", "patient", "who", "exceptionally", "retained", "SMN", "on", "one", "C1706112#ent", "<e2>", ",", "exerts", "no", "synergism", "with", "Bcl-2", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [21, 22]}}
{"token": ["We", "report", "the", "first", "case", "(", "to", "our", "knowledge", ")", "of", "C0042928#ent", "<e1>", "a", "primary", "manifestation", "invasive", "C2350529#ent", "<e2>", "which", "occurred", "in", "a", "69-year-old", "woman", "without", "immunodeficiency", "."], "h": {"id": "C0042928", "name": "C0042928#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2350529", "name": "C2350529#ent", "pos": [17, 18]}}
{"token": ["It", "is", "not", "known", "whether", "augmentation", "therapy", "AAT", "diminishes", "degradation", "of", "C0013765#ent", "<e1>", "severely", "deficient", "persons", "with", "C0024115#ent", "<e2>"], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "glucose", "(", "10", "mg/kg", ",", "C3273618#ent", "<e1>", ")", "were", "not", "influenced", "by", "the", "peripherally", "acting", "C0008429#ent", "<e2>", "neostigmine", "(", "35", "micrograms/kg", ",", "C3273618#ent", "<e1>", ")", "."], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008429", "name": "C0008429#ent", "pos": [18, 19]}}
{"token": ["The", "effects", "of", "AF-DX", "116", "(", "0.1", "mg/kg", ",", "C3273618#ent", "<e1>", ")", "were", "not", "influenced", "by", "the", "peripherally", "acting", "C0008429#ent", "<e2>", "neostigmine", "(", "35", "micrograms/kg", ",", "C3273618#ent", "<e1>", ")", "."], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008429", "name": "C0008429#ent", "pos": [19, 20]}}
{"token": ["The", "sequence", "revealed", "the", "presence", "of", "a", "936-base-pair", "C0079941#ent", "<e1>", "constitutes", "the", "C0162728#ent", "<e2>"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162728", "name": "C0162728#ent", "pos": [12, 13]}}
{"token": ["To", "report", "our", "experience", "in", "identification", "and", "treatment", "of", "C0271429#ent", "<e1>", "AOM", ")", "with", "otorrhea", "secondary", "to", "C0343401#ent", "<e2>", "CA-MRSA", ")", ",", "which", "is", "seen", "in", "children", "at", "increasing", "rates", "."], "h": {"id": "C0271429", "name": "C0271429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0343401", "name": "C0343401#ent", "pos": [17, 18]}}
{"token": ["Conversely", ",", "blocking", "the", "cell", "cycle", "C0042671#ent", "<e1>", "(", "G2/M", "block", ")", "or", "C2698905#ent", "<e2>", "(", "mid-G1", "block", ")", "inhibited", "the", "initiation", "of", "differentiation", "by", "1,25(OH)2D3", "."], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2698905", "name": "C2698905#ent", "pos": [13, 14]}}
{"token": ["C0812382#ent", "<e1>", "the", "histones", "(", "H1", ",", "H2a", ",", "H2b", ",", "C0919509#ent", "<e2>", ",", "and", "H4", ")", ",", "were", "modified", "and", "used", "as", "receptor-targeted", "DNA", "carriers", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [11, 12]}}
{"token": ["Immunosuppressive", "therapy", "C0010583#ent", "<e1>", "resulted", "in", "remission", "of", "C0034902#ent", "<e2>", "transient", "improvement", "in", "hypocalcemia", ",", "and", "disappearance", "of", "the", "LGL", "clone", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0034902", "name": "C0034902#ent", "pos": [8, 9]}}
{"token": ["Treatment", "with", "C0010583#ent", "<e1>", "and", "prednisone", "produced", "complete", "remission", "of", "the", "C0034902#ent", "<e2>"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0034902", "name": "C0034902#ent", "pos": [11, 12]}}
{"token": ["Action", "of", "C0010583#ent", "<e1>", "on", "the", "C0034902#ent", "<e2>", "the", "immune", "origin", "this", "disease", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0034902", "name": "C0034902#ent", "pos": [6, 7]}}
{"token": ["CEC", "alignment", "to", "130", "nm", "deep", "NGs", "was", "prevented", "by", "the", "inhibition", "of", "rho", ",", "but", "not", "by", "the", "inhibition", "of", "cdc42", ",", "C0812228#ent", "<e1>", ",", "or", "the", "rho", "effectors", "C1334539#ent", "<e2>", "rho", "kinase"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [30, 31]}}
{"token": ["Here", "we", "show", "that", "the", "C0033641#ent", "<e1>", "G9a", "contains", "a", "conserved", "methylation", "motif", "marked", "sequence", "similarity", "to", "C1426975#ent", "<e2>", "itself", "."], "h": {"id": "C0033641", "name": "C0033641#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1426975", "name": "C1426975#ent", "pos": [17, 18]}}
{"token": ["X-ray", "crystallography", "a", "C0221232#ent", "<e1>", "of", "information", "about", "the", "dynamic", "as", "well", "as", "C0175168#ent", "<e2>"], "h": {"id": "C0221232", "name": "C0221232#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [13, 14]}}
{"token": ["Optical", "spectroscopy", "a", "C0221232#ent", "<e1>", "of", "information", "about", "C0175168#ent", "<e2>", "is", "difficult", "to", "obtain", "from", "other", "methods", "."], "h": {"id": "C0221232", "name": "C0221232#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [8, 9]}}
{"token": ["C0012634#ent", "<e1>", "of", "the", "C0022904#ent", "<e2>", "optimally", "evaluated", "by", "dacryocystography", ",", "CT", ",", "MR", "imaging", "and", "nuclear", "scintigraphy"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0022904", "name": "C0022904#ent", "pos": [4, 5]}}
{"token": ["The", "results", "indicate", "that", "both", "compounds", "are", "antagonists", "on", "both", "B1", "and", "C1333340#ent", "<e1>", "are", "competitive", "and", "discriminate", "between", "C1424532#ent", "<e2>", "and", "B2B", "receptor", "subtypes", "."], "h": {"id": "C1333340", "name": "C1333340#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1424532", "name": "C1424532#ent", "pos": [19, 20]}}
{"token": ["We", "have", "examined", "the", "interaction", "between", "4',6-diamidino-2-phenylindole", "(", "C0057142#ent", "<e1>", ")", "and", "DNA", "using", "flow", "linear", "dichroism", "LD", ")", ",", "circular", "dichroism", "C2348923#ent", "<e2>", ")", ",", "and", "fluorescence", "techniques"], "h": {"id": "C0057142", "name": "C0057142#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2348923", "name": "C2348923#ent", "pos": [22, 23]}}
{"token": ["C0409818#ent", "<e1>", "chronic", "infantile", "neurological", "cutaneous", "articular", "syndrome", "observed", "in", "young", "children", "associates", "chronic", "urticaria", "C0009326#ent", "<e2>", "may", "cause", "deformation", "of", "the", "larger", "peripheral", "joints"], "h": {"id": "C0409818", "name": "C0409818#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [15, 16]}}
{"token": ["This", "includes", "approaches", "that", "utilize", "the", "activity", "of", "C0035541#ent", "<e1>", "as", "antisense", "oligonucleotide", "small", "interfering", "RNA", "RNase", "P-associated", "external", "guide", "sequence", ",", "C1522172#ent", "<e2>", "and", "bovine", "seminal", "RNase"], "h": {"id": "C0035541", "name": "C0035541#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1522172", "name": "C1522172#ent", "pos": [22, 23]}}
{"token": ["Human", "pancreatic", "ribonuclease", "C0035541#ent", "<e1>", "is", "homologous", "to", "C1522172#ent", "<e2>", "but", "is", "not", "cytotoxic", "."], "h": {"id": "C0035541", "name": "C0035541#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1522172", "name": "C1522172#ent", "pos": [8, 9]}}
{"token": ["The", "dipeptides", "Phe-Arg", ",", "Ser-Pro", "and", "C0061738#ent", "<e1>", "were", "identified", "among", "the", "hydrolysis", "products", "of", "perfused", "C1705889#ent", "<e2>", "."], "h": {"id": "C0061738", "name": "C0061738#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705889", "name": "C1705889#ent", "pos": [16, 17]}}
{"token": ["The", "pathological", "findings", "of", "hepatitis", "diagnosed", "during", "C0034362#ent", "<e1>", "those", "with", "C.", "burnetii", "C0264864#ent", "<e2>", "quite", "different", "and", "may", "reflect", "a", "different", "immunological", "response", "C.", "burnetii", "."], "h": {"id": "C0034362", "name": "C0034362#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0264864", "name": "C0264864#ent", "pos": [13, 14]}}
{"token": ["Thioredoxin", "(", "C1336690#ent", "<e1>", ")", "is", "an", "intracellular", "C0027203#ent", "<e2>", "that", "has", "a", "variety", "of", "activities", "as", "a", "hydrogen", "donor", "various", "intracellular", "molecules"], "h": {"id": "C1336690", "name": "C1336690#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["Thioredoxin", "(", "C1336690#ent", "<e1>", ")", "is", "a", "dithiol-reducing", "C0027203#ent", "<e2>", "that", "is", "induced", "by", "various", "oxidative", "stresses"], "h": {"id": "C1336690", "name": "C1336690#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["The", "present", "paper", "deals", "with", "an", "C0001363#ent", "<e1>", "may", "affect", "an", "area", "of", "lower", "limb", "vessels", "C0852949#ent", "<e2>", "limbs", "or", "whole", "body", "immersed", "in", "very", "warm", "water"], "h": {"id": "C0001363", "name": "C0001363#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0852949", "name": "C0852949#ent", "pos": [16, 17]}}
{"token": ["This", "C1848862#ent", "<e1>", "seems", "to", "be", "the", "result", "of", "an", "C1306587#ent", "<e2>", "with", "brain", "edema", "in", "the", "white", "matter", "vasogenic", "edema", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1306587", "name": "C1306587#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "demonstrate", "that", "inhibitory-Smads", "(", "C1334469#ent", "<e1>", "and", "Smad7", ")", ",", "but", "not", "C3828360#ent", "<e2>", "(R-)Smads", "and", "the", "common-partner", "Smad4", "can", "be", "methylated", "by", "protein", "arginine", "N-methyltransferase", "."], "h": {"id": "C1334469", "name": "C1334469#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3828360", "name": "C3828360#ent", "pos": [14, 15]}}
{"token": ["The", "basic", "polypeptide", "encoded", "at", "the", "3", "'", "end", "of", "the", "mRNA", "was", "found", "to", "be", "C1512488#ent", "<e1>", "to", "the", "basic", "C1305923#ent", "<e2>", "of", "other", "11S", "seed", "globulins", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [21, 22]}}
{"token": ["Nine", "of", "43", "(", "21", "%", ")", "patients", "died", "in", "the", "context", "of", "an", "C1708411#ent", "<e1>", ":", "six", "fatal", "Aspergillus", "infections", "three", "fatal", "C0750466#ent", "<e2>", "reported", "."], "h": {"id": "C1708411", "name": "C1708411#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0750466", "name": "C0750466#ent", "pos": [23, 24]}}
{"token": ["This", "suggests", "that", "C0027329#ent", "<e1>", "is", "not", "as", "effective", "in", "C0339573#ent", "<e2>", "as", "it", "is", "in", "normal", "tension", "glaucoma"], "h": {"id": "C0027329", "name": "C0027329#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [10, 11]}}
{"token": ["The", "activities", "of", "T-3761", "were", "lower", "than", "those", "of", "tosufloxacin", "against", "gram-positive", "bacterial", "systemic", "C0024116#ent", "<e1>", "mice", "but", "not", "against", "infections", "with", "C0343401#ent", "<e2>"], "h": {"id": "C0024116", "name": "C0024116#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0343401", "name": "C0343401#ent", "pos": [22, 23]}}
{"token": ["Hereditary", "prion", "disease", "classified", "into", "3", "major", "phenotypes", "such", "as", "familial", "CJD", ",", "Gerstmann-Straeussler-Scheinker", "disease", "C0017495#ent", "<e1>", ")", "mainly", "showing", "C0087012#ent", "<e2>", "and", "fatal", "familial", "insomunia", "."], "h": {"id": "C0017495", "name": "C0017495#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0087012", "name": "C0087012#ent", "pos": [20, 21]}}
{"token": ["C1414404#ent", "<e1>", "then", "reacts", "with", "C0034678#ent", "<e2>", "to", "produce", "Ras-S118", ",", "which", "withdraws", "an", "electron", "from", "the", "Ras-bound", "guanine", "nucleotide", "base", "produce", "a", "guanine", "nucleotide", "diphosphate", "cation", "radical", "G(+)-DP", ")", "via", "the", "Phe28", "side-chain", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [5, 6]}}
{"token": ["In", "this", "article", ",", "the", "clinical", "and", "biochemical", "effects", "long-term", "treatment", "with", "C0701303#ent", "<e1>", "of", "patients", "with", "meningiomas", ",", "breast", "cancer", "and", "C0010481#ent", "<e2>", "compared", "with", "those", "present", "in", "patients", "with", "hereditary", "glucocorticoid", "receptor", "resistance", "."], "h": {"id": "C0701303", "name": "C0701303#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [22, 23]}}
{"token": ["These", "findings", "show", "that", "HHV-8", "C3889271#ent", "<e1>", "has", "an", "enhancing", "effect", "on", "C0019693#ent", "<e2>", "replication", "in", "vitro", "suggest", "that", "the", "two", "viruses", "might", "interact", "in", "co-infected", "patients", "."], "h": {"id": "C3889271", "name": "C3889271#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [12, 13]}}
{"token": ["To", "study", "the", "effects", "of", "molecular", "interactions", "C0019693#ent", "<e1>", "replication", "and", "biology", ",", "cell", "lines", "different", "origin", "were", "transiently", "transfected", "with", "C3889271#ent", "<e2>", "and", "subsequently", "infected", "with", "C0019693#ent", "<e1>", "."], "h": {"id": "C3889271", "name": "C3889271#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [7, 8]}}
{"token": ["A", "patient", "is", "described", "who", "devloped", "a", "C0007286#ent", "<e1>", "a", "trigeminal", "sensory", "neuropathy", "the", "initial", "manifestations", "of", "C0026272#ent", "<e2>"], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026272", "name": "C0026272#ent", "pos": [17, 18]}}
{"token": ["These", "changes", "should", "be", "consistent", "with", "deficiency", "in", "TGF-beta1", "signaling", ",", "a", "pleiotropic", "factor", "controls", "ECM", "homeostasis", "by", "down-regulating", "C0623362#ent", "<e1>", "expression", "and", "inducing", "ECM", "C1136365#ent", "<e2>"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [25, 26]}}
{"token": ["We", "assessed", "whether", "mutations", "in", "the", "DHPS", "gene", "P.", "carinii", "were", "associated", "with", "exposure", "to", "C0013227#ent", "<e1>", "influenced", "outcome", "from", "C0031381#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [20, 21]}}
{"token": ["After", "d-amphetamine", "replaced", "pentobarbital", "as", "the", "C0013227#ent", "<e1>", "group", "B", ",", "d-amphetamine", ",", "pentobarbital", "and", "diazepam", "substituted", ",", "C0031381#ent", "<e2>", "substituted", "in", "part", ",", "but", "not", "haloperidol", ",", "morphine", "and", "vehicles", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [18, 19]}}
{"token": ["Trimethoprim-sulfamethoxazole", "(", "TMP-SMZ", ";", "cotrimoxazole", ")", "is", "the", "recommended", "C0013227#ent", "<e1>", "for", "the", "treatment", "of", "C0031381#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [15, 16]}}
{"token": ["During", "C1417487#ent", "<e1>", "treatment", "the", "patients", "experienced", "significantly", "less", "wheezing", ",", "dyspnoea", "and", "C0019079#ent", "<e2>", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019079", "name": "C0019079#ent", "pos": [13, 14]}}
{"token": ["GST-pi", "and", "C0537086#ent", "<e1>", "both", "consist", "of", "209", "C3539946#ent", "<e2>", "differ", "in", "only", "30", "C3539946#ent", "<e2>", "85.6", "%", "homology", ")", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [8, 9]}}
{"token": ["The", "coding", "sequence", "the", "GST", "Pi", "protein", "V79", "cells", ",", "designated", "C0537086#ent", "<e1>", ",", "consisted", "of", "627", "bp", "coding", "for", "209", "C3539946#ent", "<e2>", "aa", ")", ",", "corresponding", "to", "a", "23-kDa", "protein", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [21, 22]}}
{"token": ["Seven", "carcinogenic", "compounds", "C0041964#ent", "<e1>", ",", "ethionine", ",", "auramine", "O", "safrole", ",", "amitrole", ",", "C0050423#ent", "<e2>", "and", "thioacetamide", ")", "were", "tested", "using", "the", "white-ivory", "(", "Wi", ")", "assay", "of", "Drosophila", "melanogaster"], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0050423", "name": "C0050423#ent", "pos": [14, 15]}}
{"token": ["These", "compounds", "were", "also", "observed", "to", "have", "a", "low", "potency", "for", "inhibiting", "the", "C0010656#ent", "<e1>", "caspase-1", "and", "caspase-8", ",", "and", "C0538091#ent", "<e2>", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0538091", "name": "C0538091#ent", "pos": [20, 21]}}
{"token": ["The", "peptide", "moiety", "of", "these", "inhibitors", "defines", "their", "specificity", ";", "VAD", "is", "generic", "to", "most", "C0010656#ent", "<e1>", "and", "VEID", "is", "C0538091#ent", "<e2>", "specific", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0538091", "name": "C0538091#ent", "pos": [20, 21]}}
{"token": ["SDS-PAGE", "of", "isolated", "complexes", "showed", "near", "complete", "loss", "of", "the", "p10", "subunit", "C0010656#ent", "<e1>", "8", "but", "not", "from", "the", "C0538091#ent", "<e2>"], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0538091", "name": "C0538091#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "the", "TCR-mediated", "increase", "in", "anti-Tyr(P", ")", "antibody-bound", "C1415793#ent", "<e1>", "activity", "was", "inhibited", "by", "C0075193#ent", "<e2>", "at", "drug", "concentrations", "identical", "with", "those", "required", "for", "in", "vivo", "inhibition", "of", "TCR-dependent", "phosphoinositide", "breakdown"], "h": {"id": "C1415793", "name": "C1415793#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [15, 16]}}
{"token": ["The", "observed", "suppression", "was", "abrogated", "by", "the", "H2", "antagonists", "cimetidine", "and", "C0128486#ent", "<e1>", "but", "not", "by", "the", "H2", "antagonist", "ranitidine", "nor", "C1136312#ent", "<e2>", "chlorpheniramine", ",", "pyrilamine", "or", "diphenhydramine", "."], "h": {"id": "C0128486", "name": "C0128486#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1136312", "name": "C1136312#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "pentoxifylline", "and", "C0000096#ent", "<e1>", "can", "potentiate", "the", "C3887648#ent", "<e2>", "or", "isoproterenol", "effect", "by", "inhibiting", "phosphodiesterases", "(", "even", "in", "the", "absence", "of", "calcium", ")", "."], "h": {"id": "C0000096", "name": "C0000096#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [9, 10]}}
{"token": ["C0376515#ent", "<e1>", "is", "expressed", "by", "T", "lymphocytes", "C0026769#ent", "<e2>", "plaques", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [7, 8]}}
{"token": ["C4049874#ent", "<e1>", "proved", "to", "be", "the", "most", "active", "compound", "by", "P2", "and", "C1826529#ent", "<e2>", ",", "which", "agrees", "with", "the", "structure-activity", "relationships", "reported", "for", "these", "compounds", "thus", "far", "."], "h": {"id": "C4049874", "name": "C4049874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826529", "name": "C1826529#ent", "pos": [12, 13]}}
{"token": ["Immunophenotyping", "of", "GCTTS", "showed", "that", "both", "the", "spindle", "cell", "giant", "cell", "components", "positive", "for", "vimentin", ",", "C1413510#ent", "<e1>", ",", "CD68", ",", "HAM56", ",", "AACT", ",", "and", "C1335798#ent", "<e2>", ",", "suggesting", "monocyte-macrophage-like", "features", "."], "h": {"id": "C1413510", "name": "C1413510#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1335798", "name": "C1335798#ent", "pos": [26, 27]}}
{"token": ["Furthermore", ",", "sustained", "release", "suspensions", "of", "the", "C0282138#ent", "<e1>", "microcapsules", "were", "formulated", "with", "the", "use", "of", "0.8", "%", "C0037487#ent", "<e2>", "0.4", "%", "xanthan", "gum", "a", "suspending", "agent"], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037487", "name": "C0037487#ent", "pos": [18, 19]}}
{"token": ["This", "reaction", "was", "inhibited", "by", "the", "C0031436#ent", "<e1>", "chlorpromazine", ",", "imipramine", ",", "and", "C0016368#ent", "<e2>", "and", "by", "the", "beta-adrenergic", "blocking", "agents", "propranolol", "and", "alprenolol", "."], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [6, 7]}, "relation": "structural_class_of", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [13, 14]}}
{"token": ["The", "C0031436#ent", "<e1>", "examined", ",", "clorpromazine", ",", "C0016368#ent", "<e2>", ",", "thioridazine", "and", "trifluoperazine", ",", "were", "all", "potent", "H1", "antagonists"], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [1, 2]}, "relation": "structural_class_of", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [7, 8]}}
{"token": ["This", "decrease", ",", "especially", "in", "C1708276#ent", "<e1>", "flow", ",", "was", "much", "greater", "in", "those", "with", "C0037052#ent", "<e2>", "(", "Mean", "V(E", ")", "and", "V(F", ")", "<", "20", "cm/s", ")", "."], "h": {"id": "C1708276", "name": "C1708276#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037052", "name": "C0037052#ent", "pos": [15, 16]}}
{"token": ["Numerous", "considerations", "affect", "the", "diagnosis", "and", "management", "of", "C0878773#ent", "<e1>", "OAB", ")", "in", "older", "patients", "including", "neurologic", "and", "C0007222#ent", "<e2>", "musculoskeletal", "conditions", "diabetes", ",", "and", "psychiatric", "disorders"], "h": {"id": "C0878773", "name": "C0878773#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [18, 19]}}
{"token": ["Degradation", "of", "C1826396#ent", "<e1>", "(", "NF", ")", "proteins", "by", "Ca2", "+", "-activated", "neutral", "protease", "C4084783#ent", "<e2>", ")", "was", "studied", "in", "the", "nervous", "system", "rats", "treated", "with", "neurotoxic", "or", "non-neurotoxic", "compounds", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4084783", "name": "C4084783#ent", "pos": [14, 15]}}
{"token": ["The", "amino-terminal", "and", "carboxy-terminal", "homologies", "of", "mammalian", "soluble", "C1134446#ent", "<e1>", "the", "respective", "dehalogenases", "suggests", "that", "this", "C1134446#ent", "<e1>", "but", "not", "the", "soluble", "C1134446#ent", "<e1>", "plant", "or", "the", "C0026027#ent", "<e1>", "derives", "from", "a", "gene", "fusion"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0026027", "name": "C0026027#ent", "pos": [27, 28]}}
{"token": ["These", "include", "the", "plant", "soluble", "EHs", ",", "the", "mammalian", "soluble", "C1134446#ent", "<e1>", "the", "hepoxilin", "hydrolase", "leukotriene", "A4", "hydrolase", "the", "C0026027#ent", "<e2>", "and", "the", "insect", "juvenile", "hormone", "epoxide", "hydrolase"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0026027", "name": "C0026027#ent", "pos": [19, 20]}}
{"token": ["The", "carboxy-terminal", "residues", "(", "230", "-", "554", ")", "of", "mammalian", "soluble", "C1134446#ent", "<e1>", "homologous", "to", "haloalkane", "dehalogenase", "to", "plant", "soluble", "C1134446#ent", "<e1>", "and", "to", "C0026027#ent", "<e1>"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0026027", "name": "C0026027#ent", "pos": [24, 25]}}
{"token": ["Up", "to", "84", "%", "of", "cyclic", "nucleotide", "phosphodiesterase", "activity", "C0033993#ent", "<e1>", "either", "cyclic", "AMP", "cyclic", "GMP", "was", "destroyed", "by", "C0022471#ent", "<e2>", "injection", "."], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [19, 20]}}
{"token": ["Inhibition", "of", "licensing", "with", "6-dimethylaminopurine", "results", "in", "C0008546#ent", "<e1>", "containing", "specifically", "bound", "MCM4", "and", "C1334493#ent", "<e2>", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334493", "name": "C1334493#ent", "pos": [14, 15]}}
{"token": ["C0012634#ent", "<e1>", "that", "are", "covered", "here", "include", "hepatitis", "A", "B", ",", "C0153188#ent", "<e2>", ",", "gonorrhea", ",", "condylomata", "accuminata", "herpes", "simplex", "AIDS", "(", "acquired", "immune-deficiency", "syndrome", "and", "several", "enteric", "diseases", "namely", "amebiasis", ",", "giardiasis", ",", "shigellosis", "and", "salmonellosis", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0153188", "name": "C0153188#ent", "pos": [11, 12]}}
{"token": ["The", "three", "major", "C0012634#ent", "<e1>", "characterized", "by", "genital", "ulcers", "genital", "herpes", "C0153188#ent", "<e2>", ",", "and", "chancroid", "--", "are", "common", ",", "with", "genital", "herpes", "most", "common", "in", "industrialized", "countries", "chancroid", "being", "most", "common", "in", "developing", "countries"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0153188", "name": "C0153188#ent", "pos": [11, 12]}}
{"token": ["The", "significant", "underexpression", "of", "C2700453#ent", "<e1>", "mRNA", "in", "C1418677#ent", "<e2>", "patients", "compared", "with", "normal", "controls", "that", "a", "decreased", "dosage", "of", "the", "PMP-22", "gene", "the", "most", "likely", "pathogenetic", "mechanism", "in", "C1418677#ent", "<e2>", "."], "h": {"id": "C2700453", "name": "C2700453#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418677", "name": "C1418677#ent", "pos": [8, 9]}}
{"token": ["The", "C0027203#ent", "<e1>", "cleaves", "at", "many", "points", "within", "the", "C1839079#ent", "<e2>", "stretch", "and", "usually", "hydrolyzes", "the", "5'-ApT-3", "'", "linkage", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1839079", "name": "C1839079#ent", "pos": [9, 10]}}
{"token": ["Two", "previously", "unidentified", "human", "C1419281#ent", "<e1>", "genes", "have", "been", "isolated", ",", "cdc25A", "and", "C1563402#ent", "<e2>", "."], "h": {"id": "C1419281", "name": "C1419281#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1563402", "name": "C1563402#ent", "pos": [13, 14]}}
{"token": ["Pancreatitis-associated", "protein", "I", "C1424700#ent", "<e1>", ",", "also", "known", "as", "HIP", ",", "C3538773#ent", "<e2>", ",", "or", "Reg2", "protein", ",", "has", "recently", "been", "implicated", "in", "the", "endogenous", "regulation", "of", "inflammation", "."], "h": {"id": "C1424700", "name": "C1424700#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538773", "name": "C3538773#ent", "pos": [11, 12]}}
{"token": ["Unexpectedly", ",", "full-length", "adiponectin", "significantly", "increased", "C1705592#ent", "<e1>", "and", "MCP-1", "production", ",", "and", "did", "not", "abrogate", "C3273763#ent", "<e2>", "chemokine", "expression", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273763", "name": "C3273763#ent", "pos": [16, 17]}}
{"token": ["Rabbits", "with", "experimentally", "induced", "C0025295#ent", "<e1>", "given", "single", "25-mg/kg", "doses", "of", "C0771721#ent", "<e2>", "or", "cefpiramide", "."], "h": {"id": "C0025295", "name": "C0025295#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0771721", "name": "C0771721#ent", "pos": [11, 12]}}
{"token": ["To", "obtain", "a", "clue", "for", "the", "C0025517#ent", "<e1>", "glycosaminoglycans", "(", "GAG", ")", "in", "connective", "tissue", "diseases", "C1442905#ent", "<e2>", ")", ",", "a", "device", "of", "screening", "test", "excretion", "pattern", "of", "urinary", "GAG", "was", "achieved", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1442905", "name": "C1442905#ent", "pos": [16, 17]}}
{"token": ["We", "conclude", "that", "C0052429#ent", "<e1>", "can", "be", "considered", "as", "an", "alternative", "C0003374#ent", "<e2>", "for", "multiple", "drug", "resistant", "falciparum", "malaria", "."], "h": {"id": "C0052429", "name": "C0052429#ent", "pos": [3, 4]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [11, 12]}}
{"token": ["C0052429#ent", "<e1>", "is", "an", "efficacious", "C0003374#ent", "<e2>", "also", "displays", "antischistosomal", "properties", "."], "h": {"id": "C0052429", "name": "C0052429#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [5, 6]}}
{"token": ["C0052429#ent", "<e1>", "is", "a", "new", "C0003374#ent", "<e2>", "clears", "parasites", "from", "the", "circulation", "more", "rapidly", "than", "quinine", ",", "but", "its", "effect", "on", "mortality", "is", "unclear", "."], "h": {"id": "C0052429", "name": "C0052429#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [5, 6]}}
{"token": ["Here", ",", "we", "show", "that", "reconstitution", "of", "scid/scid", "mice", "with", "minor", "histocompatibility", "mismatched", "naive", "C0206744#ent", "<e1>", "in", "skin", "alterations", "strikingly", "resembled", "human", "C1419789#ent", "<e2>", "clinically", ",", "histopathologically", "and", "in", "cytokine", "expression"], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [22, 23]}}
{"token": ["159", ",", "385", "-", "394", ")", "was", "shown", "to", "be", "accompanied", "by", "an", "increased", "transcription", "of", "the", "rat", "C1959603#ent", "<e1>", "indicating", "interleukin", "exerts", "its", "effect", "via", "increased", "C3539768#ent", "<e2>", "mRNA", "synthesis", "."], "h": {"id": "C1959603", "name": "C1959603#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [27, 28]}}
{"token": ["At", "present", ",", "at", "least", "three", "subtypes", "of", "phospholipase", "A2", "been", "identified", "in", "cardiac", "structures", "i.e.", ",", "a", "low", "C1959603#ent", "<e1>", "a", "cytoplasmic", "C3539768#ent", "<e2>", "a", "plasmalogen-specific", "phospholipase", "A2", "."], "h": {"id": "C1959603", "name": "C1959603#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [23, 24]}}
{"token": ["Endotoxin", "in", "vitro", "no", "C1959603#ent", "<e1>", "but", "it", "activated", "the", "hydrolytic", "activity", "exogenous", "C3539768#ent", "<e2>"], "h": {"id": "C1959603", "name": "C1959603#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [13, 14]}}
{"token": ["Although", "it", "is", "recognized", "that", "obstruction", "of", "the", "sinus", "ostia", "which", "is", "surgically", "correctable", "contributes", "to", "recurrent", "C0037199#ent", "<e1>", "allergic", "and", "nonallergic", "inflammation", "may", "contribute", "to", "or", "mimic", "C0948780#ent", "<e2>"], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0948780", "name": "C0948780#ent", "pos": [28, 29]}}
{"token": ["Cisapride", "demonstrated", "efficacy", "comparable", "with", "or", "superior", "to", "that", "of", "metoclopramide", ",", "and", "was", "at", "least", "as", "effective", "as", "C0008783#ent", "<e1>", "and", "ranitidine", "in", "patients", "with", "C0017168#ent", "<e2>"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [26, 27]}}
{"token": ["AF64A", "also", "irreversibly", "inhibited", "partially", "purified", "C0008415#ent", "<e1>", "acetylcholinesterase", "but", "not", "lactate", "dehydrogenase", "alcohol", "dehydrogenase", "C0007075#ent", "<e2>", "or", "chymotrypsinogen", ",", "enzymes", "that", "do", "not", "use", "choline", "as", "a", "substrate", "or", "product", "."], "h": {"id": "C0008415", "name": "C0008415#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007075", "name": "C0007075#ent", "pos": [15, 16]}}
{"token": ["Channel", "inhibition", "by", "C1705556#ent", "<e1>", "was", "not", "affected", "by", "blocking", "C0031671#ent", "<e2>", "protein", "kinase", "However", ",", "whereas", "cAMP", "prevented", "channel", "blocking", "by", "C1705556#ent", "<e1>", ",", "blocking", "protein", "kinase", "A", "to", "abolish", "the", "inhibitory", "effects", "of", "C1705556#ent", "<e1>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "C1705556#ent", "<e1>", "acted", "synergistically", "with", "angiotensin", "II", "C0031671#ent", "<e2>", "serotonin", ",", "or", "carbachol", "to", "stimulate", "DNA", "synthesis"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggest", "that", "in", "aortic", "endothelial", "cells", "C1705556#ent", "<e1>", "produces", "a", "sustained", "activation", "of", "a", "C0031671#ent", "<e2>", "hydrolyzing", "phosphatidylcholine", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [16, 17]}}
{"token": ["C0002144#ent", "<e1>", "and", "C1511755#ent", "<e2>", "improved", "cutaneous", "blood", "flow", "tissue", "oxygenation", "but", "only", "C1511755#ent", "<e2>", "could", "significantly", "reduce", "cutaneous", "and", "skeletal", "muscle", "necrosis", "p", "<", "0.001", ")", "."], "h": {"id": "C0002144", "name": "C0002144#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1511755", "name": "C1511755#ent", "pos": [3, 4]}}
{"token": ["Among", "the", "possible", "mechanisms", "which", "may", "cause", "wheezing", "or", "C0282556#ent", "<e1>", "episodes", "a", "genetically", "determined", "C0001645#ent", "<e2>", "a", "hyperresponsiveness", "of", "alpha-adrenoceptors", "has", "been", "postulated", "."], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [15, 16]}}
{"token": ["The", "bronchial", "response", "alpha-adrenoreceptor", "stimulation", "been", "investigated", "in", "normal", "and", "C0282556#ent", "<e1>", "subjects", "with", "a", "specific", "alpha-receptor", "agonist", "methoxamine", "hydrochloride", "after", "atropine", "and", "C0001645#ent", "<e2>"], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [23, 24]}}
{"token": ["Significantly", "low", "beta", "2-stimulant", "responsiveness", "of", "pancreatic", "beta-cell", "observed", "in", "continuously", "medicated", "and", "active", "C0282556#ent", "<e1>", "subjects", ",", "indicating", "C0001645#ent", "<e2>"], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [19, 20]}}
{"token": ["In", "myocardial", "infarction", "patients", "with", "C0018802#ent", "<e1>", "nitroglycerin", "and", "C0037533#ent", "<e2>", "a", "favorable", "effect", "on", "systemic", "oxygen", "regimen", "and", "central", "hemodynamics"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [9, 10]}}
{"token": ["C0018802#ent", "<e1>", "induced", "in", "3", "dogs", "by", "occluding", "the", "anterior", "interventricular", "artery", "and", "C0037533#ent", "<e2>", "injected", "intravenously", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "a", "single", "dose", "C0356588#ent", "<e1>", "was", "studied", "in", "15", "patients", "with", "C0020437#ent", "<e2>", "of", "malignancy", "."], "h": {"id": "C0356588", "name": "C0356588#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [14, 15]}}
{"token": ["Similarly", "duration", "of", "normocalcemia", "after", "treatment", "with", "C0356588#ent", "<e1>", "and", "the", "control", "of", "the", "symptoms", "of", "C0020437#ent", "<e2>", "were", "independent", "of", "infusion", "rate", "."], "h": {"id": "C0356588", "name": "C0356588#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [16, 17]}}
{"token": ["It", "is", "recommended", "to", "consider", "combined", "therapy", "C0356588#ent", "<e1>", "and", "calcitonin", "in", "the", "emergency", "management", "C0020437#ent", "<e2>", "crisis", "."], "h": {"id": "C0356588", "name": "C0356588#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [15, 16]}}
{"token": ["Our", "objective", "was", "to", "evaluate", "the", "CT", "appearance", "of", "C0238377#ent", "<e1>", "associated", "with", "IV", "abuse", "oral", "medications", "to", "compare", "the", "findings", "of", "C0238377#ent", "<e1>", "related", "to", "C0025810#ent", "<e1>", "with", "those", "findings", "seen", "with", "other", "drugs", "."], "h": {"id": "C0238377", "name": "C0238377#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025810", "name": "C0025810#ent", "pos": [26, 27]}}
{"token": ["C0013295#ent", "<e1>", "induced", "by", "mepirizole", "were", "also", "markedly", "prevented", "with", "C0085154#ent", "<e2>", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0085154", "name": "C0085154#ent", "pos": [10, 11]}}
{"token": ["Six", "healthy", "volunteers", "six", "patients", "with", "C0013295#ent", "<e1>", "placebo", "or", "300", "mg", "C0085154#ent", "<e2>", "once", "at", "night", "or", "twice", "daily", "(", "morning", "and", "evening", ")", "for", "a", "week", "in", "a", "random", ",", "cross-over", "fashion"], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0085154", "name": "C0085154#ent", "pos": [12, 13]}}
{"token": ["On", "immunohistochemistry", ",", "the", "tumors", "were", "positive", "for", "epithelial", "markers", ",", "including", "CK7", "and", "CK18", ",", "vimentin", ",", "C3538869#ent", "<e1>", ",", "AMACR", ",", "and", "neuroendocrine", "markers", "such", "as", "C1414404#ent", "<e2>", "and", "CD57", "."], "h": {"id": "C3538869", "name": "C3538869#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414404", "name": "C1414404#ent", "pos": [28, 29]}}
{"token": ["As", "a", "first", "step", "toward", "that", "goal", ",", "we", "have", "created", "a", "cell", "line", "highly", "inducible", "Ad", "C1709313#ent", "<e1>", "and", "E1B", "genes", ",", "which", "are", "essential", "for", "C1412056#ent", "<e2>", "production", "."], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1412056", "name": "C1412056#ent", "pos": [27, 28]}}
{"token": ["The", "\"", "C0035339#ent", "<e1>", "\"", "effect", "of", "C0376637#ent", "<e2>", "is", "discussed", "as", "likely", "pathogenic", "explanation", "for", "this", "complications", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0376637", "name": "C0376637#ent", "pos": [7, 8]}}
{"token": ["Retinal", "dehydrogenase", "type", "II", "C1705626#ent", "<e1>", ")", "catalyzes", "this", "last", "step", "in", "the", "production", "of", "C0022265#ent", "<e2>", "the", "early", "embryo", "possibly", "producing", "this", "putative", "morphogen", "to", "initiate", "pattern", "formation"], "h": {"id": "C1705626", "name": "C1705626#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [15, 16]}}
{"token": ["Injection", "of", "mRNAs", "for", "either", "mouse", "Raldh1", "or", "C1705626#ent", "<e1>", "stimulated", "C0022265#ent", "<e2>", "synthesis", "in", "frog", "embryos", "at", "the", "blastula", "stage", "C0022265#ent", "<e2>", "normally", "undetectable", "."], "h": {"id": "C1705626", "name": "C1705626#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [11, 12]}}
{"token": ["In", "homogenates", "of", "mutant", "hemispheres", ",", "C1416969#ent", "<e1>", ",", "MBP", ",", "PLP", "and", "C1413553#ent", "<e2>", "were", "undetectable", "or", "at", "trace", "levels", "comparison", "to", "controls.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1416969", "name": "C1416969#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413553", "name": "C1413553#ent", "pos": [13, 14]}}
{"token": ["This", "study", "is", "a", "family-based", "genetic", "association", "analysis", "examining", "the", "C1416969#ent", "<e1>", "MAG", ")", "and", "2',3'-cyclic", "nucleotide", "3'-phosphodiesterase", "C1413553#ent", "<e2>", ")", "genes", "in", "schizophrenia", "."], "h": {"id": "C1416969", "name": "C1416969#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413553", "name": "C1413553#ent", "pos": [18, 19]}}
{"token": ["These", "data", "suggest", "that", "insulin", "regulates", "C1417562#ent", "<e1>", "function", "via", "CaMKII-dependent", "phosphorylation", ",", "and", "these", "events", "play", "a", "role", "in", "insulin-regulated", "C2982484#ent", "<e2>", "trafficking", "in", "adipocytes", "likely", "involving", "C1417562#ent", "<e1>", "motor", "activity"], "h": {"id": "C2982484", "name": "C2982484#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1417562", "name": "C1417562#ent", "pos": [6, 7]}}
{"token": ["We", "investigated", "whether", "polymorphism", "in", "the", "oestrogen", "receptor-alpha", "C1414463#ent", "<e1>", ")", "gene", "is", "related", "to", "oestrogen-dependent", "benign", "C0042131#ent", "<e2>"], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042131", "name": "C0042131#ent", "pos": [17, 18]}}
{"token": ["Second", ",", "unlike", "LPS-induced", "KC", "expression", "in", "macrophages", "and", "platelet-derived", "growth", "KC", "expression", "in", "3T3", "cells", "C2697656#ent", "<e1>", "induction", "of", "KC", "in", "endothelial", "cells", "to", "require", "activation", "of", "C0010536#ent", "<e2>"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [28, 29]}}
{"token": ["Phagocytic", "uptake", "in", "the", "absence", "of", "plasma", "of", "both", "untreated", "and", "opsonized", "yeast", "is", "strongly", "inhibited", "by", "C0064631#ent", "<e1>", ",", "but", "is", "unaffected", "by", "C0053413#ent", "<e2>", "."], "h": {"id": "C0064631", "name": "C0064631#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0053413", "name": "C0053413#ent", "pos": [24, 25]}}
{"token": ["Other", "therapeutical", "efforts", "aim", "at", "maintaining/restoring", "calcium/phosphate", "homeostasis", ":", "improving", "intestinal", "calcium", "absorption", "using", "calcium", "supplementation", "vitamin", "D", "derivates", ")", "and", "avoiding", "increased", "urinary", "calcium", "loss", "using", "C0008273#ent", "<e1>", ")", "prevent", "or", "counteract", "a", "C0020503#ent", "<e2>"], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0020503", "name": "C0020503#ent", "pos": [34, 35]}}
{"token": ["We", "report", "a", "child", "with", "C0027341#ent", "<e1>", "and", "steroid-responsive", ",", "frequently", "relapsing", "C0027726#ent", "<e2>"], "h": {"id": "C0027341", "name": "C0027341#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "the", "immunohistochemical", "alterations", "of", "C1419140#ent", "<e1>", "(PV)-expressing", "interneurons", "in", "the", "hippocampus", "after", "transient", "C0007785#ent", "<e2>", "gerbils", "in", "comparison", "with", "neuronal", "nitric", "oxide", "synthase", "interneurons", "."], "h": {"id": "C1419140", "name": "C1419140#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [15, 16]}}
{"token": ["To", "clarify", "the", "role", "of", "C0694890#ent", "<e1>", "signaling", "components", "in", "enteric", "nervous", "system", "C1417023#ent", "<e2>", ")", "development", ",", "we", "evaluated", "C1417023#ent", "<e2>", "anatomy", "and", "intestinal", "contractility", "in", "mice", "heterozygous", "for", "C0694890#ent", "<e1>", ",", "GFRalpha1", "and", "Ret", "ligands"], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417023", "name": "C1417023#ent", "pos": [13, 14]}}
{"token": ["Activation", "of", "EDNRB", "specifically", "enhances", "the", "effect", "of", "C0694890#ent", "<e1>", "signaling", "on", "the", "proliferation", "of", "uncommitted", "C1417023#ent", "<e2>", "progenitors", "."], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417023", "name": "C1417023#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "the", "antigenicity", "of", "cardiac", "structures", "Leu-7", ",", "NSE", "(", "Neurone", "specific", "C1414402#ent", "<e1>", ")", "and", "PGP", "(", "C0030956#ent", "<e2>", "9.5", "."], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}}
{"token": ["Clinical", "and", "serological", "study", "of", "household", "contacts", "index", "patients", "suffering", "from", "C0276622#ent", "<e1>", "the", "high", "infectivity", "of", "C0042721#ent", "<e2>", "HAV", ")", "for", "susceptible", "contacts"], "h": {"id": "C0276622", "name": "C0276622#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [17, 18]}}
{"token": ["Studies", "on", "natural", "cytotoxicity", "peripheral", "blood", "monocytes", "conducted", "in", "patients", "with", "C0276622#ent", "<e1>", "patients", "with", "chronic", "aggressive", "hepatitis", "linked", "to", "C0042721#ent", "<e2>", "and", "in", "asymptomatic", "carriers", "of", "HBs", "antigen", "."], "h": {"id": "C0276622", "name": "C0276622#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [20, 21]}}
{"token": ["Prostaglandin", "E", "levels", "were", "measured", "in", "the", "blood", "of", "47", "patients", "with", "C0276622#ent", "<e1>", "VHB", ")", ",", "17", "patients", "with", "C0042721#ent", "<e2>", "VHA", ")", "and", "15", "healthy", "donors"], "h": {"id": "C0276622", "name": "C0276622#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [20, 21]}}
{"token": ["A", "19-year-old", "woman", "developed", "acute", "jaundice", "abnormal", "liver", "tests", "C0276622#ent", "<e1>", "presumably", "non-A", "non-B.", "The", "C0042721#ent", "<e2>", "on", "the", "4th", "day", "after", "admission", ",", "was", "complicated", "by", "aplastic", "anemia"], "h": {"id": "C0276622", "name": "C0276622#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [15, 16]}}
{"token": ["Refsum's", "disease", "C0034960#ent", "<e1>", "heredopathia", "atactica", "polyneuritiformis", "is", "an", "C3899988#ent", "<e2>", "clinical", "features", "of", "which", "include", "retinitis", "pigmentosa", "blindness", ",", "anosmia", ",", "deafness", ",", "sensory", "neuropathy", "ataxia", "and", "accumulation", "of", "phytanic", "acid", "plasma-", "and", "lipid-containing", "tissues", "."], "h": {"id": "C0034960", "name": "C0034960#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}}
{"token": ["C0796355#ent", "<e1>", "and", "Lyl1", "are", "aberrantly", "C3890227#ent", "<e2>", "in", "leukemia", "as", "a", "result", "of", "chromosomal", "translocations", "or", "other", "genetic", "or", "epigenetic", "events"], "h": {"id": "C0796355", "name": "C0796355#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890227", "name": "C3890227#ent", "pos": [6, 7]}}
{"token": ["Hallmarks", "of", "C0751383#ent", "<e1>", "cognitive", "and", "motor", "decline", ",", "C0036572#ent", "<e2>", "and", "blindness", "due", "to", "retinitis", "pigmentosa"], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}}
{"token": ["C0751383#ent", "<e1>", "Batten", "disease", "JNCL", ")", "is", "a", "neurodegenerative", "disorder", "by", "blindness", ",", "C0036572#ent", "<e2>", ",", "cognitive", "decline", "early", "death"], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["The", "gall-bladder", "tissues", "obtained", "from", "7", "cases", "of", "C0267853#ent", "<e1>", "and", "1", "case", "of", "C0701818#ent", "<e2>", "were", "used", "as", "materials", "in", "the", "present", "study", "."], "h": {"id": "C0267853", "name": "C0267853#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0701818", "name": "C0701818#ent", "pos": [14, 15]}}
{"token": ["Systemic", "diseases", "associated", "with", "dementia", "include", "electrolyte", "disturbances", "C3665349#ent", "<e1>", ",", "vitamin", "deficiency", "alcohol", "or", "drug", "intoxication", "C0039128#ent", "<e2>", "and", "HIV", "infection"], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [17, 18]}}
{"token": ["The", "expression", "of", "C1414556#ent", "<e1>", "and", "YI51", "antigens", "on", "cells", "cultured", "with", "rG-CSF", "or", "C0175697#ent", "<e2>", "was", "maintained", "compared", "with", "that", "of", "control", "cells"], "h": {"id": "C1414556", "name": "C1414556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [14, 15]}}
{"token": ["These", "experiments", "show", "that", "the", "C0080296#ent", "<e1>", "synergy", "with", "C1336923#ent", "<e2>", "can", "play", "a", "direct", "role", "in", "the", "in", "vitro", "transformation", "of", "murine", "B", "lymphoid", "cells"], "h": {"id": "C0080296", "name": "C0080296#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336923", "name": "C1336923#ent", "pos": [9, 10]}}
{"token": ["C3537327#ent", "<e1>", "mRNA", "and", "protein", "expression", "unchanged", "in", "adapted", "mucosa", ",", "whereas", "C3273507#ent", "<e2>", "mRNA", "and", "protein", "levels", "decreased", "."], "h": {"id": "C3537327", "name": "C3537327#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [12, 13]}}
{"token": ["Heat", "shock", "42", "degrees", "C", "for", "30", "min", "increased", "C3537327#ent", "<e1>", "levels", "but", "caused", "no", "change", "in", "C3273507#ent", "<e2>", "."], "h": {"id": "C3537327", "name": "C3537327#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [17, 18]}}
{"token": ["However", ",", "it", "is", "not", "known", "whether", "protectants", "like", "C0086444#ent", "<e1>", "(", "DXR", ")", "and", "C3537278#ent", "<e2>", "(", "AMF", ")", "can", "prevent", "DOX-mediated", "bone", "damage", "."], "h": {"id": "C0086444", "name": "C0086444#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3537278", "name": "C3537278#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "in", "mice", "pretreated", "with", "C0035179#ent", "<e1>", "plus", "AMPT", ",", "BRC", "significantly", "enhanced", "the", "locomotor", "C0002763#ent", "<e2>", "effect", "of", "apomorphine", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "C3273686#ent", "<e1>", "inhibition", "of", "MFO", "C3541394#ent", "<e2>", "may", "not", "be", "dependent", "upon", "the", "reactivity", "of", "the", "C3273686#ent", "<e1>", "towards", "sulfhydryl", "groups"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273686", "name": "C3273686#ent", "pos": [4, 5]}}
{"token": ["RKIP", "physically", "interacted", "with", "four", "C0031727#ent", "<e1>", "of", "the", "NF-kappaB", "activation", "pathway", "NF-kappaB-inducing", "kinase", "C1435846#ent", "<e2>", "IKKalpha", ",", "and", "IKKbeta", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1435846", "name": "C1435846#ent", "pos": [14, 15]}}
{"token": ["C3536710#ent", "<e1>", "facilitation", "of", "lordosis", "was", "correlated", "with", "a", "reduction", "of", "C4284890#ent", "<e2>", "MOR", "internalization", "."], "h": {"id": "C3536710", "name": "C3536710#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4284890", "name": "C4284890#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "estrogen", "could", "enhance", "some", "steps", "of", "metastasis", "in", "endometrial", "cancers", "and", "C3536710#ent", "<e1>", "could", "inhibit", "the", "C4284890#ent", "<e2>", "regardless", "of", "growth-inhibition", "."], "h": {"id": "C3536710", "name": "C3536710#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4284890", "name": "C4284890#ent", "pos": [19, 20]}}
{"token": ["Chemoprophylaxis", "does", "not", "reduce", "the", "severity", "of", "C1761609#ent", "<e1>", "gastric", "bile", "unaffected", "by", "these", "agents", "and", "induces", "a", "worse", "C3714636#ent", "<e2>", "than", "gastric", "acid"], "h": {"id": "C1761609", "name": "C1761609#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [19, 20]}}
{"token": ["LDL", "was", "isolated", "from", "knee", "joint", "synovial", "fluid", "C1442521#ent", "<e1>", ")", "from", "subjects", "with", "C0027121#ent", "<e2>", "also", "from", "matched", "plasma", "samples", "."], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027121", "name": "C0027121#ent", "pos": [14, 15]}}
{"token": ["Conditions", "highlighted", "in", "this", "review", "include", ":", "diabetes", "mellitus", "C0028754#ent", "<e1>", "the", "ex-premature", "infant", ";", "the", "child", "with", "an", "C0041912#ent", "<e2>", "malignant", "hyperthermia", ";", "and", "the", "use", "of", "monoamine", "oxidase", "inhibitors"], "h": {"id": "C0028754", "name": "C0028754#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [19, 20]}}
{"token": ["The", "C0079429#ent", "<e1>", "was", "coamplified", "with", "the", "C1335783#ent", "<e2>", "for", "hydroxyurea", "resistance", "from", "hydroxyurea", "(Hu)-resistant", "Leishmania", "variants", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335783", "name": "C1335783#ent", "pos": [7, 8]}}
{"token": ["In", "marked", "contrast", ",", "agents", "stimulating", "the", "protein", "kinase", "A", "pathway", "like", "C0917964#ent", "<e1>", "or", "dibutyryl", "cAMP", ",", "did", "not", "affect", "tyrosine", "phosphorylation", "C1413291#ent", "<e2>", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413291", "name": "C1413291#ent", "pos": [23, 24]}}
{"token": ["iii", ")", "The", "cAMP-dependent", "mitogenic", "cascade", "by", "TSH", "and", "C0917964#ent", "<e1>", "did", "not", "involve", "the", "phosphorylation", "and", "nuclear", "translocation", "C1413291#ent", "<e2>", "and", "p44", "MAP", "kinases", "at", "any", "time", "during", "the", "entire", "prereplicative", "phase", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413291", "name": "C1413291#ent", "pos": [19, 20]}}
{"token": ["High", "levels", "of", "IgE", "and", "IgG", "antibodies", "specific", "to", "A.", "fumigatus", "antigens", "were", "detected", "in", "C0004031#ent", "<e1>", "while", "only", "IgG", "antibodies", "were", "seen", "in", "C0004030#ent", "<e2>", "."], "h": {"id": "C0004031", "name": "C0004031#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [24, 25]}}
{"token": ["Mechanistic", "investigations", "that", "inhibition", "of", "HDAC", "enzymes", "by", "C3537177#ent", "<e1>", "led", "to", "a", "significant", "reduction", "in", "the", "transcription", "of", "C1417679#ent", "<e2>", "specifically", "associated", "with", "HR", ",", "including", "RAD51", "."], "h": {"id": "C3537177", "name": "C3537177#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [19, 20]}}
{"token": ["C0600388#ent", "<e1>", "ERKs", ")", "constitute", "a", "family", "of", "C0072402#ent", "<e2>", "in", "a", "variety", "of", "cell-signaling", "pathways", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [8, 9]}}
{"token": ["The", "C0600388#ent", "<e1>", "ERKs", ")", "comprise", "a", "class", "of", "C0072402#ent", "<e2>", "are", "activated", "in", "response", "to", "a", "wide", "variety", "of", "extracellular", "signals", "transduced", "via", "receptor", "tyrosine", "kinases"], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [9, 10]}}
{"token": ["Mitogen", "activated", "protein", "kinases", "MAP", ")", "or", "C0600388#ent", "<e1>", "ERK", ")", "are", "a", "family", "of", "C0072402#ent", "<e2>", "are", "activated", "very", "rapidly", "in", "response", "to", "many", "extracellular", "stimuli", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [15, 16]}}
{"token": ["Their", "livers", "were", "investigated", "histologically", "and", "histochemically", "for", "glycogen", ",", "RNA", ",", "fat", ",", "alkaline", "and", "acid", "phosphatases", "adenosine", "triphosphatase", "C2932861#ent", "<e1>", ",", "glucose-6-phosphatase", ",", "glucose-6-phosphate", "dehydrogenase", "succinic", "dehydrogenase", "and", "alkaline", "and", "C0035542#ent", "<e2>"], "h": {"id": "C2932861", "name": "C2932861#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [32, 33]}}
{"token": ["However", ",", "in", "earlier", "studies", "surrogate", "measures", "of", "infection", "rather", "than", "C0009450#ent", "<e1>", "associated", "with", "decreased", "frequencies", "of", "C1336827#ent", "<e2>"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1336827", "name": "C1336827#ent", "pos": [18, 19]}}
{"token": ["C0009450#ent", "<e1>", ",", "which", "have", "been", "renamed", "as", "C1336827#ent", "<e2>", "WHO", ",", "are", "endemic", "in", "the", "developing", "world", "not", "newly", "appeared", "diseases", ",", "but", "diseases", "affecting", "humans", "in", "these", "decades", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336827", "name": "C1336827#ent", "pos": [8, 9]}}
{"token": ["These", "results", "indicate", "that", "C1705356#ent", "<e1>", "promotes", "sustained", "ERK1/2", "activation", "through", "repression", "of", "C1705047#ent", "<e2>", "transcription", ",", "resulting", "in", "promotion", "of", "tumorigenicity", "and", "metastasis", "."], "h": {"id": "C1705356", "name": "C1705356#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705047", "name": "C1705047#ent", "pos": [13, 14]}}
{"token": ["C0724549#ent", "<e1>", "is", "subjected", "to", "2", "metabolic", "pathways", "by", "CYP2C8", "and", "C1142644#ent", "<e2>", "."], "h": {"id": "C0724549", "name": "C0724549#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}}
{"token": ["Atorvastatin", ",", "C0724549#ent", "<e1>", ",", "lovastatin", "and", "simvastatin", "are", "predominantly", "metabolised", "by", "the", "C1142644#ent", "<e2>"], "h": {"id": "C0724549", "name": "C0724549#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [13, 14]}}
{"token": ["C0919426#ent", "<e1>", ",", "the", "coding", "gene", "the", "ethanol", "inducible", "C3887686#ent", "<e2>", "is", "polymorphic", "at", "the", "RsaI", "restriction", "site", "the", "5", "'", "flanking", "region"], "h": {"id": "C0919426", "name": "C0919426#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [9, 10]}}
{"token": ["Bernard-Soulier", "Syndrome", "C1319466#ent", "<e1>", ")", "is", "a", "rare", "C0005779#ent", "<e2>", "characterized", "by", "thrombocytopenia", "and", "giant", "platelets", "."], "h": {"id": "C1319466", "name": "C1319466#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [8, 9]}}
{"token": ["Four", "chromatin", "fractions", "obtained", "and", "analyzed", "by", "gel", "electrophoresis", "their", "protein", "and", "DNA", "components", "by", "hybridization", "of", "their", "C0011522#ent", "<e1>", "with", "an", "androgen", "regulated", "for", "transcribed", "DNA", "sequence", "and", "by", "[3H]dihydrotestosterone", "exchange", "assay", "C0038317#ent", "<e2>", "competition", "experiment", "for", "specific", "androgen", "binding"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [33, 34]}}
{"token": ["The", "pharmacokinetics", "(", "PK", ")", "and", "safety", "of", "fluvastatin", ",", "a", "C0360714#ent", "<e1>", "were", "assessed", "in", "subjects", "with", "C1565662#ent", "<e2>", "nephrotic", "syndrome"], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "implicate", "that", "C4283956#ent", "<e1>", "functions", "as", "a", "translational", "silencer", "C1705323#ent", "<e2>", "expression", "and", "support", "the", "hypothesis", "that", "dysregulated", "RNA-binding", "of", "C4283956#ent", "<e1>", "promotes", "C1705323#ent", "<e2>", "expression", "in", "neoplasia", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4283956", "name": "C4283956#ent", "pos": [4, 5]}}
{"token": ["Generally", ",", "C1823613#ent", "<e1>", "considerably", "less", "specific", "than", "C0022194#ent", "<e2>", "but", "this", "may", "be", "partly", "compensated", "in", "the", "cell", "by", "valine", "concentrations", "higher", "than", "those", "of", "noncognate", "acids", "."], "h": {"id": "C1823613", "name": "C1823613#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022194", "name": "C0022194#ent", "pos": [8, 9]}}
{"token": ["C1823613#ent", "<e1>", "a", "close", "homolog", "of", "C0022194#ent", "<e2>", "misactivates", "threonine", ",", "alpha-aminobutyrate", ",", "and", "cysteine", "."], "h": {"id": "C1823613", "name": "C1823613#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022194", "name": "C0022194#ent", "pos": [6, 7]}}
{"token": ["Endothelin", "is", "an", "endogenous", "C0042397#ent", "<e1>", "and", "plays", "an", "important", "role", "in", "pathogenesis", "of", "C0151445#ent", "<e2>", "phenomenon", "."], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151445", "name": "C0151445#ent", "pos": [14, 15]}}
{"token": ["These", "data", "indicate", "that", "spontaneously", "active", "cation", "channels", "inhibited", "by", "a", "tonic", "inhibitory", "pathway", "G(alphaq)/G(alpha11)-mediated", "stimulation", "of", "C2987155#ent", "<e1>", "to", "generate", "C0011967#ent", "<e2>", "which", "activates", "PKC", "to", "inhibit", "channel", "opening", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [21, 22]}}
{"token": ["C2987155#ent", "<e1>", "activity", "renders", "two", "products", ",", "IP(3", ")", "and", "C0011967#ent", "<e2>", ",", "and", "C0011967#ent", "<e2>", "can", "be", "metabolized", "to", "PA", "by", "the", "action", "of", "DAG-kinase", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [10, 11]}}
{"token": ["This", "gives", "PMEA", "the", "unique", "potential", "of", "being", "useful", "in", "the", "treatment", "of", "C0019348#ent", "<e1>", "well", "as", "the", "underlying", "C0035369#ent", "<e2>"], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035369", "name": "C0035369#ent", "pos": [19, 20]}}
{"token": ["A", "correlation", "was", "found", "between", "the", "ability", "of", "these", "C0017860#ent", "<e1>", "to", "stimulate", "the", "activity", "of", "C1416655#ent", "<e2>", "in", "vitro", "to", "mimic", "the", "effects", "of", "PMA", "on", "the", "EGF", "receptor", "intact", "cells", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [16, 17]}}
{"token": ["We", "describe", "a", "case", "of", "C3150926#ent", "<e1>", "CDA", ")", "presenting", "at", "week", "20", "of", "pregnancy", "with", "C0020305#ent", "<e2>", "very", "severe", "anaemia", "."], "h": {"id": "C3150926", "name": "C3150926#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [16, 17]}}
{"token": ["The", "expression", "of", "dynein", "light", "chain", "DLC", ")", "(", "also", "known", "as", "protein", "inhibitor", "C0669368#ent", "<e1>", "PIN", "]", ")", "was", "significantly", "stimulated", "in", "PC12", "cells", "overexpressing", "C1705323#ent", "<e2>", "."], "h": {"id": "C0669368", "name": "C0669368#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [26, 27]}}
{"token": ["There", "have", "been", "some", "observations", "on", "how", "new", "C0003308#ent", "<e1>", "such", "as", "voriconazole", "and", "C0935942#ent", "<e2>", "are", "impacting", "the", "shift", "in", "pathogens", "and", "drug", "resistance"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [8, 9]}, "relation": "therapeutic_class_of", "t": {"id": "C0935942", "name": "C0935942#ent", "pos": [14, 15]}}
{"token": ["Steroidogenic", "factor", "1", "SF-1", ")", ",", "a", "C1334043#ent", "<e1>", "of", "NGFI-B", ",", "also", "activates", "the", "C0038304#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038304", "name": "C0038304#ent", "pos": [15, 16]}}
{"token": ["In", "late", "pregnancy", "levels", "of", "cyclooxygenase", "2", "C1367485#ent", "<e1>", ")", "increased", "in", "parallel", "to", "C2985150#ent", "<e2>", "levels", "."], "h": {"id": "C1367485", "name": "C1367485#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2985150", "name": "C2985150#ent", "pos": [14, 15]}}
{"token": ["p130Cas", "is", "a", "major", "C1333677#ent", "<e1>", "tightly", "binds", "v-Crk", "in", "v-crk-transformed", "cells", "and", "C3853558#ent", "<e2>", "in", "v-src-transformed", "cells", "."], "h": {"id": "C1333677", "name": "C1333677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3853558", "name": "C3853558#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "BK", "channel", "openers", "NS-1619", ",", "C0028067#ent", "<e1>", "estradiol", ",", "tamoxifen", ":", "C1416602#ent", "<e2>", "beta-subunit", "activators", ",", "respectively", ")", "significantly", "diminished", "AP", "generation", "and", "spontaneous", "mechanical", "activity"], "h": {"id": "C0028067", "name": "C0028067#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416602", "name": "C1416602#ent", "pos": [14, 15]}}
{"token": ["Most", "often", "the", "syndrome", "has", "been", "associated", "with", "adenomas", "of", "the", "pars", "intermedia", "the", "C0032002#ent", "<e1>", "and", "bilateral", "C0342492#ent", "<e2>", "nodular", "hyperplasia", "primarily", "the", "zona", "fasciculata"], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0342492", "name": "C0342492#ent", "pos": [18, 19]}}
{"token": ["Five", "main", "classes", "of", "prophylactic", "drug", "currently", "used", ":", "beta-blockers", ",", "C0006684#ent", "<e1>", "serotonin", "modulators", ",", "C0003211#ent", "<e2>", "and", "ergot", "compounds"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [16, 17]}}
{"token": ["There", "have", "been", "numerous", "medications", "used", "to", "prevent", "migraine", "headaches", "including", "b-blockers", ",", "C0006684#ent", "<e1>", "anticonvulsants", ",", "and", "C0003211#ent", "<e2>"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [18, 19]}}
{"token": ["Operative", "treatment", "C0012624#ent", "<e1>", "still", "an", "important", "part", "of", "the", "treatment", "for", "C0410649#ent", "<e2>"], "h": {"id": "C0012624", "name": "C0012624#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0410649", "name": "C0410649#ent", "pos": [12, 13]}}
{"token": ["5", ")", "C0442874#ent", "<e1>", "the", "most", "important", "differential", "diagnosis", "of", "C1704945#ent", "<e2>", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [10, 11]}}
{"token": ["Antibodies", "to", "glycolipids", "have", "recently", "been", "found", "to", "be", "elevated", "in", "a", "substantial", "proportion", "of", "patients", "with", "motor", "neuron", "diseases", "various", "C0442874#ent", "<e1>", "and", "classical", "C1704945#ent", "<e2>", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [25, 26]}}
{"token": ["To", "determine", "the", "incidence", "of", "entrapment", "C0442874#ent", "<e1>", "in", "patients", "with", "amyotrophic", "lateral", "sclerosis", "C1704945#ent", "<e2>", ")", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [14, 15]}}
{"token": ["This", "sequence", ",", "except", "for", "the", "methionine", ",", "corresponds", "to", "C0815040#ent", "<e1>", "15", "of", "the", "C1412821#ent", "<e2>", "ORF", ")", "encoding", "the", "predicted", "GDH", "(", "ORF", "APE", "1386", ")", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [15, 16]}}
{"token": ["We", "have", "also", "studied", "whether", "selenomethionine", "can", "modify", "the", "effect", "of", "overexpression", "of", "C1420276#ent", "<e1>", "during", "differentiation", "of", "C1705347#ent", "<e2>"], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705347", "name": "C1705347#ent", "pos": [18, 19]}}
{"token": ["Significantly", ",", "the", "amount", "and", "enzymatic", "activity", "C1709432#ent", "<e1>", "were", "not", "altered", "in", "C1970209#ent", "<e2>", "tumorigenic", "cells", "relative", "to", "its", "amount", "and", "activity", "in", "nontumorigenic", "Ad5", "cells", "."], "h": {"id": "C1709432", "name": "C1709432#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1970209", "name": "C1970209#ent", "pos": [13, 14]}}
{"token": ["Adult", "respiratory", "distress", "syndrome", "C0035222#ent", "<e1>", ")", "could", "be", "related", "to", "C0001883#ent", "<e2>"], "h": {"id": "C0035222", "name": "C0035222#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [11, 12]}}
{"token": ["On", "catecholamine", "secretion", "from", "the", "cells", ",", "the", "effect", "of", "C1412228#ent", "<e1>", "was", "markedly", "potentiated", "by", "addition", "of", "C0029904#ent", "<e2>", ",", "an", "inhibitor", "of", "Na+/K+", "ATPase"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [18, 19]}}
{"token": ["C1412228#ent", "<e1>", "increased", "22Na+", "influx", "into", "the", "cells", "treated", "with", "C0029904#ent", "<e2>", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [10, 11]}}
{"token": ["We", "studied", "the", "effect", "of", "original", "C0012512#ent", "<e1>", "Noopept", "(", "N-phenylacetyl-L-prolylglycine", "ethyl", "ester", "GVS-111", ")", "with", "C0242913#ent", "<e2>", "and", "neuroprotective", "properties", "the", "expression", "of", "mRNA", "for", "neurotropic", "factors", "NGF", "and", "BDNF", "in", "rat", "hippocampus", "."], "h": {"id": "C0012512", "name": "C0012512#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242913", "name": "C0242913#ent", "pos": [16, 17]}}
{"token": ["This", "C0012512#ent", "<e1>", ",", "which", "revealed", "the", "C0242913#ent", "<e2>", "previous", "experiments", ",", "was", "injected", "to", "the", "pups", "in", "dose", "of", "1", "mg/kg", "from", "8", "to", "19", "days", "of", "life", "."], "h": {"id": "C0012512", "name": "C0012512#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242913", "name": "C0242913#ent", "pos": [7, 8]}}
{"token": ["In", "this", "immunohistochemical", "study", "the", "authors", "detected", "the", "expression", "of", "C0079068#ent", "<e1>", "in", "keratinocytes", "(", "C1705460#ent", "<e2>", ")", "from", "30", "psoriatic", "patients", "before", "and", "after", "QDCC", "treatment", "and", "12", "normal", "subjects", "control", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705460", "name": "C1705460#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", "a", "common", "mutation", "in", "C2828029#ent", "<e1>", "accounts", "for", "the", "majority", "of", "C0015625#ent", "<e2>", "Ashkenazi-Jewish", "families", "."], "h": {"id": "C2828029", "name": "C2828029#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [14, 15]}}
{"token": ["In", "order", "to", "determine", "the", "fraction", "of", "Fanconi", "anaemia", "by", "C2828029#ent", "<e1>", "mutations", ",", "we", "used", "reverse", "transcription", "PCR", "chemical", "mismatch", "cleavage", "CMC", ")", "to", "examine", "the", "C2828029#ent", "<e1>", "cDNA", "in", "17", "C0015625#ent", "<e1>", "cell", "lines"], "h": {"id": "C2828029", "name": "C2828029#ent", "pos": [10, 11]}, "relation": "gene_associated_with_disease", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [32, 33]}}
{"token": ["Collectively", ",", "our", "findings", "not", "only", "draw", "attention", "to", "the", "extra-neuronal", "functions", "of", "C1332735#ent", "<e1>", "but", "also", "propose", "C1332735#ent", "<e1>", "as", "a", "novel", "and", "potential", "therapeutic", "target", "of", "C0033978#ent", "<e1>"], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [28, 29]}}
{"token": ["The", "cofractionation", "of", "an", "ATP-dependent", "C0920283#ent", "<e1>", "an", "origin-specific", "DNA-binding", "activity", "that", "RIP60", "and", "C1427816#ent", "<e2>", "may", "be", "involved", "in", "initiation", "of", "chromosomal", "DNA", "synthesis", "mammalian", "cells"], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1427816", "name": "C1427816#ent", "pos": [14, 15]}}
{"token": ["Covalent", "radiolabeling", "ATP", "indicated", "that", "the", "C0920283#ent", "<e1>", "activity", "resided", "in", "a", "100-kDa", "polypeptide", ",", "C1427816#ent", "<e2>", "."], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1427816", "name": "C1427816#ent", "pos": [15, 16]}}
{"token": ["Corresponding", "frequencies", "in", "patients", "with", "C3273872#ent", "<e1>", "alone", "were", "66", "%", "for", "C1710302#ent", "<e2>", "and", "34", "%", "for", "DR3/4", "(", "p", "less", "than", "10(-6", ")", "and", "10(-3", ")", "respectively", ")", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1710302", "name": "C1710302#ent", "pos": [12, 13]}}
{"token": ["We", "report", "here", "the", "effects", "of", "mutations", "in", "two", "other", "(", "meiosis-specific", ")", "genes", ",", "C3812251#ent", "<e1>", "and", "MEK1/MRE4", ",", "that", "encode", "a", "chromosome", "structure", "and", "a", "C0033640#ent", "<e2>", "respectively", "."], "h": {"id": "C3812251", "name": "C3812251#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [27, 28]}}
{"token": ["HOP1", "and", "C3812251#ent", "<e1>", "encode", "structural", "components", "of", "axial", "elements", "MEK1", "encodes", "a", "C0033640#ent", "<e2>"], "h": {"id": "C3812251", "name": "C3812251#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [13, 14]}}
{"token": ["We", "used", "pergolide", "to", "treat", "10", "patients", "with", "C0030567#ent", "<e1>", "had", "first", "responded", "to", ",", "and", "then", "failed", ",", "C0006230#ent", "<e2>"], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [19, 20]}}
{"token": ["We", "propose", "that", "expression", "of", "the", "C0079429#ent", "<e1>", "detected", "by", "DN34", "is", "regulated", "by", "C1708477#ent", "<e2>", ",", "therefore", ",", "that", "it", "is", "a", "candidate", "C0079429#ent", "<e1>", "for", "PWS", "and/or", "AS", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1708477", "name": "C1708477#ent", "pos": [14, 15]}}
{"token": ["Angelman", "syndrome", "AS", ")", "is", "a", "relatively", "frequent", "disorder", "of", "psychomotor", "development", "by", "loss", "of", "function", "a", "C0079429#ent", "<e1>", "from", "chromosome", "15q11-q13", "a", "region", "subject", "to", "C1708477#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1708477", "name": "C1708477#ent", "pos": [26, 27]}}
{"token": ["On", "the", "other", "hand", ",", "the", "overall", "success", "rate", "for", "C0041952#ent", "<e1>", "61", "%", "(", "245/401", ")", "with", "the", "C1707129#ent", "<e2>", "70", "%", "(", "96/138", ")", "with", "the", "Dornier", "MPL9000", "."], "h": {"id": "C0041952", "name": "C0041952#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1707129", "name": "C1707129#ent", "pos": [19, 20]}}
{"token": ["The", "duration", "of", "tonic", "seizure", "induced", "by", "C4283758#ent", "<e1>", "was", "also", "inhibited", "by", "C1956071#ent", "<e2>", "but", "the", "duration", "of", "clonic", "seizures", "unchanged", "."], "h": {"id": "C4283758", "name": "C4283758#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1956071", "name": "C1956071#ent", "pos": [13, 14]}}
{"token": ["We", "report", "herewith", "a", "case", "of", "C0701825#ent", "<e1>", "an", "18-month-old", "infant", "with", "C0271454#ent", "<e2>", "CSOM", ")", "."], "h": {"id": "C0701825", "name": "C0701825#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0271454", "name": "C0271454#ent", "pos": [12, 13]}}
{"token": ["Beyond", "suppression", "of", "Stat", "activities", "C1835417#ent", "<e1>", "inhibits", "IFN-inducible", "phosphorylation/activation", "of", "the", "C1456380#ent", "<e2>", "suggesting", "a", "dual", "mechanism", "by", "which", "this", "abnormal", "fusion", "protein", "blocks", "IFN", "transcriptional", "responses", "."], "h": {"id": "C1835417", "name": "C1835417#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [12, 13]}}
{"token": ["The", "present", "study", "demonstrates", "that", "treatment", "with", "a", "clinically", "used", "C1443643#ent", "<e1>", "improves", "diaphragm", "function", "restoring", "myosin", "content", "in", "C0018802#ent", "<e2>", "."], "h": {"id": "C1443643", "name": "C1443643#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [19, 20]}}
{"token": ["The", "products", "can", "be", "regarded", "as", "cosmetics", ",", "but", "may", "also", "be", "regulated", "as", "medicinal", "products", "they", "are", "marketed", "against", "C0037274#ent", "<e1>", "such", "as", "atopic", "dermatitis", "C0020757#ent", "<e2>", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [20, 21]}, "relation": "nichd_parent_of", "t": {"id": "C0020757", "name": "C0020757#ent", "pos": [26, 27]}}
{"token": ["The", "aromatic", "retinoid", "Etretinate", "therapeutically", "used", "in", "severe", "forms", "of", "psoriasis", "and", "in", "various", "C0037274#ent", "<e1>", "with", "disorders", "of", "keratinization", "as", "for", "example", "C0020757#ent", "<e2>", ",", "dyskeratosis", "follicularis", "Darier", "and", "pityriasis", "rubra", "pilaris"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0020757", "name": "C0020757#ent", "pos": [23, 24]}}
{"token": ["In", "addition", "to", "various", "C0017759#ent", "<e1>", "the", "enzyme", "hydrolyzed", "phosphorylated", "C3539946#ent", "<e2>", "in", "particular", "phosphotyrosine", "."], "h": {"id": "C0017759", "name": "C0017759#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [10, 11]}}
{"token": ["Antibiotics", "(", "AB", ")", "are", "sometimes", "used", "in", "patients", "taking", "C0003211#ent", "<e1>", "AID", ")", "(", "steroidal", "and", "C0003212#ent", "<e2>", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003212", "name": "C0003212#ent", "pos": [17, 18]}}
{"token": ["Twelve", "different", "C0003211#ent", "<e1>", "NSAID", ")", ",", "five", "C0003212#ent", "<e2>", "morphine", "and", "chloroquine", "have", "been", "added", "at", "various", "concentrations", "to", "in", "vitro", "preparations", "of", "guinea-pig", "ileum"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003212", "name": "C0003212#ent", "pos": [8, 9]}}
{"token": ["This", "review", "demonstrates", "that", "bacterial", "DNA", "unmethylated", "CpG", "motifs", "induces", "C0003864#ent", "<e1>", "and", "indicates", "an", "important", "pathogenic", "role", "for", "bacterial", "DNA", "C0003869#ent", "<e2>"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0003869", "name": "C0003869#ent", "pos": [21, 22]}}
{"token": ["The", "patient", "had", "no", "features", "of", "C0410787#ent", "<e1>", "furthermore", ",", "a", "skin", "biopsy", "no", "signs", "Marfan's", "Ehlers", "C0013720#ent", "<e2>"], "h": {"id": "C0410787", "name": "C0410787#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0013720", "name": "C0013720#ent", "pos": [17, 18]}}
{"token": ["Majority", "of", "the", "reported", "inhibitors", "show", "their", "inhibitory", "effects", "towards", "other", "phylogenetically", "related", "C0031727#ent", "<e1>", "also", ",", "like", "C0243045#ent", "<e2>", "CDKs", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [18, 19]}}
{"token": ["The", "cell", "cycle", "regulated", "by", "C0031727#ent", "<e1>", "such", "as", "the", "C0243045#ent", "<e2>", "CDKs", ")", "and", "non-CDKs", ",", "which", "include", "Aurora", "and", "polo-like", "kinases", "as", "well", "as", "checkpoint", "proteins"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [10, 11]}}
{"token": ["Since", "1986", ",", "researchers", "have", "noted", "a", "C0039082#ent", "<e1>", "of", "Klebsiella", "pneumoniae", "pyogenic", "C0023885#ent", "<e2>", "is", "complicated", "by", "endophthalmitis", "or", "central", "nervous", "system", "infections"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023885", "name": "C0023885#ent", "pos": [13, 14]}}
{"token": ["The", "C3539752#ent", "<e1>", "overexpressed", "in", "Escherichia", "coli", "used", "for", "gel", "retardation", "C0011519#ent", "<e2>", "experiments", "."], "h": {"id": "C3539752", "name": "C3539752#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [11, 12]}}
{"token": ["In", "insulin-treated", "rats", ",", "C1333714#ent", "<e1>", "attenuated", "the", "C0020616#ent", "<e2>", "observed", "in", "controls", "and", "increased", "corticosterone", "levels", "."], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [8, 9]}}
{"token": ["Naloxone", ",", "CCK-8", "and", "C1333714#ent", "<e1>", "significantly", "raised", "blood", "glucose", "levels", "insulin", "induced", "C0020616#ent", "<e2>", "."], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [13, 14]}}
{"token": ["C0033858#ent", "<e1>", "such", "as", "8-methoxypsoralen", "and", "C0041086#ent", "<e2>", "(", "TMP", ")", "are", "used", "in", "photochemotherapy", "for", "the", "treatment", "of", "a", "variety", "of", "epidermal", "proliferative", "diseases", "."], "h": {"id": "C0033858", "name": "C0033858#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C0041086", "name": "C0041086#ent", "pos": [6, 7]}}
{"token": ["Experimental", "autoimmune", "encephalomyelitis", "EAE", ")", ",", "an", "animal", "model", "C1417325#ent", "<e1>", "can", "be", "prevented", "by", "feeding", "myelin", "basic", "protein", "MBP", ")", "or", "C1418655#ent", "<e2>", "PLP", ")", "."], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418655", "name": "C1418655#ent", "pos": [22, 23]}}
{"token": ["More", "patients", "with", "C0034063#ent", "<e1>", "black", ",", "and", "had", "C0011849#ent", "<e2>", "and", "preexisting", "hypertension", "than", "those", "with", "chest", "pain"], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["Differential", "recruitment", "of", "SRC-1", "and", "C1705506#ent", "<e1>", "by", "ER-alpha", "and", "C1705471#ent", "<e2>", "in", "the", "presence", "of", "beta-estradiol", "and", "4-OHT", "may", "be", "central", "to", "the", "response", "of", "the", "tumor", "to", "endocrine", "treatment"], "h": {"id": "C1705506", "name": "C1705506#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705471", "name": "C1705471#ent", "pos": [10, 11]}}
{"token": ["Whole", "body", "calcium", ",", "phosphorus", "and", "nitrogen", "have", "been", "measured", "by", "in", "vivo", "neutron", "activation", "analysis", "patients", "with", "C1561643#ent", "<e1>", "including", "9", "with", "C0221040#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0221040", "name": "C0221040#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "long-term", "exposure", "to", "aluminium", "on", "the", "development", "of", "Alzheimer-type", "neuropathological", "changes", "have", "been", "studied", "post-mortem", "in", "patients", "with", "C1561643#ent", "<e1>", "did", "not", "have", "C0221040#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0221040", "name": "C0221040#ent", "pos": [26, 27]}}
{"token": ["Among", "their", "many", "functions", "is", "the", "production", "of", "cytokines", "related", "to", "C1418938#ent", "<e1>", "(", "PRL", ")", ",", "including", "decidual", "prolactin-related", "protein", "C4085342#ent", "<e2>", ")", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4085342", "name": "C4085342#ent", "pos": [21, 22]}}
{"token": ["C1708477#ent", "<e1>", "a", "fundamental", "role", "in", "cancer", "and", "some", "C0015398#ent", "<e2>", "including", "Beckwith-Wiedemann", "syndrome", "BWS", ")", ",", "a", "disorder", "of", "prenatal", "overgrowth", "predisposition", "to", "embryonal", "malignancies", "as", "Wilms", "tumor"], "h": {"id": "C1708477", "name": "C1708477#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015398", "name": "C0015398#ent", "pos": [9, 10]}}
{"token": ["Inhibition", "of", "tyrosine", "kinase", "activity", "genistein", "or", "C0600438#ent", "<e1>", "DNA", "synthesis", "induced", "by", "C1336626#ent", "<e2>", ",", "and", "a", "neutralizing", "antibody", "platelet-derived", "growth", "factor", "no", "effect", "DNA", "synthesis"], "h": {"id": "C0600438", "name": "C0600438#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336626", "name": "C1336626#ent", "pos": [13, 14]}}
{"token": ["C0608437#ent", "<e1>", "is", "responsible", "for", "the", "irreversible", "metabolism", "of", "C0020740#ent", "<e2>", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [9, 10]}}
{"token": ["Morphological", "changes", "in", "the", "central", "organs", "immunogenesis", "were", "more", "severe", "after", "the", "administration", "of", "C0062203#ent", "<e1>", "than", "after", "C0733383#ent", "<e2>", "."], "h": {"id": "C0062203", "name": "C0062203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0733383", "name": "C0733383#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "if", "ethynylestradiol", "(EE)-induced", "C0008370#ent", "<e1>", "is", "associated", "with", "scratching", "in", "rats", "and", "if", "C2825264#ent", "<e2>", ",", "a", "kappa", "opioid", "receptor", "agonist", "with", "antipruritic", "effects", "human", "uremic", "pruritus", "would", "antagonize", "such", "scratching", "."], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2825264", "name": "C2825264#ent", "pos": [15, 16]}}
{"token": ["Ovarian", "suppression", "LHRH", "C2987634#ent", "<e1>", "may", "benefit", "a", "subset", "of", "women", "with", "recurrent", "C0006666#ent", "<e2>"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006666", "name": "C0006666#ent", "pos": [13, 14]}}
{"token": ["HNEAcid", "(", "300", "micro", "m", ")", "did", "not", "displace", "the", "binding", "of", "beta-adrenergic", "receptor", "C0242975#ent", "<e1>", "demonstrating", "the", "selectivity", "of", "HNEAcid", "for", "the", "C0000503#ent", "<e2>"], "h": {"id": "C0242975", "name": "C0242975#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0000503", "name": "C0000503#ent", "pos": [23, 24]}}
{"token": ["The", "EGR-1", "gene", "an", "immediate", "C1705964#ent", "<e1>", "gene", "encoding", "a", "zinc", "finger", "C0812382#ent", "<e2>"], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [12, 13]}}
{"token": ["Immunobiochemical", "characterization", "of", "these", "viral", "antigens", "that", "p55", "is", "a", "phosphoprotein", ",", "and", "C1705964#ent", "<e1>", "has", "strong", "C0812382#ent", "<e2>", "to", "single-stranded", "DNA"], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [17, 18]}}
{"token": ["A", "48-year-old", "woman", "presented", "with", "acute", ",", "C0033771#ent", "<e1>", ",", "sharply", "demarcated", ",", "erythematous", ",", "maculopapulous", "C0015230#ent", "<e2>", "in", "the", "anogenital", "area", "with", "disseminated", "maculae", "the", "back", "."], "h": {"id": "C0033771", "name": "C0033771#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [16, 17]}}
{"token": ["He", "was", "admitted", "twice", "to", "our", "university", "hospital", "continuous-remittent", "fever", "with", "a", "C0033771#ent", "<e1>", ",", "macular", "evanescent", "Still", "C0015230#ent", "<e2>", "severe", "splenomegaly", ",", "leucopenia", ",", "thrombocytopenia", ",", "and", "sudden", "aggravation", "of", "anemia", "."], "h": {"id": "C0033771", "name": "C0033771#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [18, 19]}}
{"token": ["To", "explore", "how", "the", "silencing", "factor", "C2699247#ent", "<e1>", "regulates", "the", "composition", "and", "function", "of", "C0008546#ent", "<e2>", "at", "the", "rDNA", ",", "the", "association", "of", "histones", "and", "RNA", "polymerase", "II", "the", "rDNA", "was", "measured", "by", "chromatin", "immunoprecipitation"], "h": {"id": "C2699247", "name": "C2699247#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [14, 15]}}
{"token": ["Together", ",", "these", "data", "demonstrate", "that", "protein", "deacetylation", "the", "only", "essential", "function", "of", "C2699247#ent", "<e1>", "in", "creating", "silenced", "C0008546#ent", "<e2>", "."], "h": {"id": "C2699247", "name": "C2699247#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [18, 19]}}
{"token": ["We", "then", "carried", "out", "in", "vitro", "transcription", "experiments", "and", "observed", "that", "C2699247#ent", "<e1>", "does", "not", "repress", "transcription", "with", "either", "naked", "DNA", "templates", "C0008546#ent", "<e2>", "assembled", "from", "native", "(", "and", "mostly", "unacetylated", ")", "histones", "."], "h": {"id": "C2699247", "name": "C2699247#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [22, 23]}}
{"token": ["At", "the", "molecular", "level", "loss", "of", "Hmt1", "'s", "catalytic", "activity", "in", "decreased", "C2699247#ent", "<e1>", "and", "dimethylated", "Arg-3", "histone", "H4", "occupancy", "across", "silent", "C0008546#ent", "<e2>"], "h": {"id": "C2699247", "name": "C2699247#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [22, 23]}}
{"token": ["Recent", "clinical", "data", "C1120110#ent", "<e1>", ",", "a", "new", "direct", "C3537174#ent", "<e2>", "suggest", "favorable", "results", "in", "patients", "with", "hypertension", "and", "a", "possible", "new", "treatment", "option", "."], "h": {"id": "C1120110", "name": "C1120110#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537174", "name": "C3537174#ent", "pos": [9, 10]}}
{"token": ["C1335796#ent", "<e1>", ",", "GCA", "and", "CAG", "are", "overrepresented", "in", "TBP", "C1417679#ent", "<e2>", "of", "other", "species", ",", "suggesting", "that", "opa", "arrays", "were", "amplified", "from", "motifs", "overrepresented", "in", "ancestral", "species"], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["At", "C1335796#ent", "<e1>", ",", "9", "of", "13", "such", "C1417679#ent", "<e2>", "were", "more", "robustly", "expressed", "in", "the", "right", "hippocampus", "while", "only", "1", "gene", "was", "predominantly", "expressed", "in", "the", "left", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}}
{"token": ["Two", "assessors", "observed", "and", "scored", "pain", "simultaneously", "with", "the", "C1849718#ent", "<e1>", "at", "rest", "and", "during", "C0030193#ent", "<e2>"], "h": {"id": "C1849718", "name": "C1849718#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [15, 16]}}
{"token": ["Dyskeratosis", "congenita", "DC", ")", "is", "an", "inherited", "C3808553#ent", "<e1>", "is", "characterized", "by", "lacey", "reticular", "hyperpigmentation", "the", "skin", ",", "dystrophic", "nails", "mucous", "membrane", "leukoplakia", "C0030312#ent", "<e2>", "."], "h": {"id": "C3808553", "name": "C3808553#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [23, 24]}}
{"token": ["Changes", "in", "both", "C0014442#ent", "<e1>", "activities", "and", "MDA", "concentration", "were", "unremarkable", "following", "acute", "C0394006#ent", "<e2>", "injection", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [13, 14]}}
{"token": ["The", "maximum", "amount", "of", "H/D", "exchange", "was", "observed", "at", "50", "-", "55", "degrees", "C", "for", "both", "C0014442#ent", "<e1>", "while", "in", "the", "presence", "of", "C0394006#ent", "<e2>", "it", "was", "observed", "at", "lower", "temperatures"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [23, 24]}}
{"token": ["In", "vitro", "assays", "demonstrate", "that", "C1420025#ent", "<e1>", "binds", "through", "its", "src", "homology", "3", "domain", "C1420552#ent", "<e2>", ",", "and", "immunoprecipitation", "analysis", "the", "antiendophilin", "antibody", "that", "C1420025#ent", "<e1>", "is", "stably", "associated", "with", "C1420552#ent", "<e2>", "in", "the", "nerve", "terminal"], "h": {"id": "C1420025", "name": "C1420025#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420552", "name": "C1420552#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "show", "that", "compounds", "that", "disrupt", "interactions", "of", "the", "SH3", "domain", "C1420025#ent", "<e1>", "with", "dynamin", "and", "C1420552#ent", "<e2>", "impair", "synaptic", "vesicle", "endocytosis", "in", "a", "living", "synapse"], "h": {"id": "C1420025", "name": "C1420025#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420552", "name": "C1420552#ent", "pos": [18, 19]}}
{"token": ["In", "humans", ",", "the", "intersensory", "conflict", "may", "additionally", "lead", "to", "a", "C0231218#ent", "<e1>", ",", "commonly", "referred", "to", "as", "space", "motion", "sickness", "C1419249#ent", "<e2>", ")", ",", "a", "kinetosis", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419249", "name": "C1419249#ent", "pos": [21, 22]}}
{"token": ["The", "translocation", "produces", "an", "invariant", "chimaeric", "C1840524#ent", "<e1>", "transcript", "containing", "the", "amino", "terminal", "half", "NUP98", "fused", "in", "frame", "to", "C1333922#ent", "<e2>", "."], "h": {"id": "C1840524", "name": "C1840524#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333922", "name": "C1333922#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "inhibition", "of", "the", "cardiac", "(Na+,K+)ATPase", "corresponding", "to", "low", "affinity", "ouabain", "binding", "sites", "seems", "to", "be", "responsible", "for", "both", "the", "C0007209#ent", "<e1>", "and", "cardiotoxic", "effects", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [27, 28]}}
{"token": ["Therefore", ",", "inhibition", "of", "the", "cardiac", "(Na+,K+)-ATPase", "corresponding", "to", "low", "affinity", "ouabain", "binding", "sites", "seems", "to", "be", "responsible", "for", "both", "the", "C0007209#ent", "<e1>", "and", "cardiotoxic", "effects", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [27, 28]}}
{"token": ["To", "compare", "the", "efficacy", "and", "safety", "of", "lamotrigine", "and", "C0002600#ent", "<e1>", "in", "controlling", "C0030193#ent", "<e2>", "peripheral", "neuropathy", "diabetic", "patients", "."], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "indicate", "that", "C0002600#ent", "<e1>", "elicits", "its", "analgesic", "effect", "chronic", "myofascial", "pain", "reducing", "the", "transmission", "of", "C0030193#ent", "<e2>", "stimuli", "from", "myofascial", "tissues", "than", "by", "reducing", "overall", "pain", "sensitivity"], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [17, 18]}}
{"token": ["Based", "on", "prior", "uncontrolled", "observations", ",", "we", "hypothesized", "that", "C0002600#ent", "<e1>", "or", "mexiletine", "would", "improve", "the", "C0030193#ent", "<e2>"], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "the", "C2936882#ent", "<e1>", "and", "progesterone", "receptor", "contents", "of", "the", "residual", "tumor", "masses", "C1161438#ent", "<e2>", "treatment", "were", "about", "the", "same", "as", "those", "of", "untreated", "tumors", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [14, 15]}}
{"token": ["Determining", "the", "in", "vitro", "sensitivity", "of", "HAdV", "to", "antiviral", "agents", "not", "an", "easy", "C0310298#ent", "<e1>", "because", "HAdV", "C1413668#ent", "<e2>", "reduction", "assays", "are", "difficult", "to", "interpret", "and", "may", "take", "more", "than", "1", "week", "."], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413668", "name": "C1413668#ent", "pos": [17, 18]}}
{"token": ["Of", "the", "three", "adrenal", "enzymes", "tested", ",", "both", "3", "C0033310#ent", "<e1>", "11-hydroxylase", "were", "inhibited", "by", "gossypol", ",", "but", "not", "C0038304#ent", "<e2>", "."], "h": {"id": "C0033310", "name": "C0033310#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038304", "name": "C0038304#ent", "pos": [19, 20]}}
{"token": ["However", ",", "several", "exceptions", "to", "this", "rule", "were", "observed", ",", "arguing", "against", "a", "direct", "inhibition", "of", "C0058980#ent", "<e1>", "by", "mutant", "C0525678#ent", "<e2>", "."], "h": {"id": "C0058980", "name": "C0058980#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "replication", "of", "a", "Deltagamma(1)34.5", "mutant", "(", "R3616", ")", "in", "12", "genetically", "defined", "cancer", "cell", "lines", "correlates", "with", "suppression", "of", "C0058980#ent", "<e1>", "but", "not", "with", "the", "genotype", "of", "C0525678#ent", "<e2>", "."], "h": {"id": "C0058980", "name": "C0058980#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [29, 30]}}
{"token": ["Furthermore", ",", "cell", "viability", "reduced", "in", "response", "to", "C0286651#ent", "<e1>", "treatment", "in", "proliferating", "and", "differentiating", "C1414069#ent", "<e2>", ",", "but", "not", "in", "differentiated", "cells"], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414069", "name": "C1414069#ent", "pos": [15, 16]}}
{"token": ["In", "general", ",", "C0298987#ent", "<e1>", "immunolabeling", "in", "the", "human", "fetal", "C0235267#ent", "<e2>", "was", "more", "intense", "when", "compared", "to", "adult", "C0235267#ent", "<e2>", "."], "h": {"id": "C0298987", "name": "C0298987#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [10, 11]}}
{"token": ["There", "is", "close", "linkage", "between", "canine", "C1860707#ent", "<e1>", "and", "the", "C0022680#ent", "<e2>", "PKD1", ")", ",", "as", "has", "been", "observed", "in", "humans", "and", "other", "mammalian", "species", "."], "h": {"id": "C1860707", "name": "C1860707#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022680", "name": "C0022680#ent", "pos": [10, 11]}}
{"token": ["Several", "other", "synthetic", "direct", "inhibitors", "C2700041#ent", "<e1>", "(", "such", "as", "FXV673", ",", "C0672234#ent", "<e2>", ",", "KFA-1411", ")", "are", "in", "a", "pre-clinical", "stage", "research", "."], "h": {"id": "C2700041", "name": "C2700041#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0672234", "name": "C0672234#ent", "pos": [12, 13]}}
{"token": ["These", "data", "suggest", "that", "temafloxacin", "causes", "C0002880#ent", "<e1>", "most", "likely", "secondary", "to", "C0020951#ent", "<e2>", "formation", "."], "h": {"id": "C0002880", "name": "C0002880#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [12, 13]}}
{"token": ["C0086438#ent", "<e1>", "is", "associated", "with", "high", "incidence", "of", "chronic", "sinopulmonary", "infection", "chronic", "diarrhoea", "malignancy", ",", "C0022408#ent", "<e2>", "hepatitis", "."], "h": {"id": "C0086438", "name": "C0086438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [15, 16]}}
{"token": ["The", "presence", "of", "C4288963#ent", "<e1>", "increases", "the", "C1334912#ent", "<e2>", "rate", "and", "the", "influence", "on", "allograft", "survival", "is", "evident", "at", "the", "fifth", "year", "of", "assessment", "."], "h": {"id": "C4288963", "name": "C4288963#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334912", "name": "C1334912#ent", "pos": [7, 8]}}
{"token": ["High", "invasive", "was", "found", "in", "those", "cell", "lines", "expressing", "high", "levels", "of", "C0007428#ent", "<e1>", "L", "or", "matrix", "metal", "proteases", "C0919336#ent", "<e2>", ")", ",", "either", "alone", "or", "in", "combination", "."], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [19, 20]}}
{"token": ["Upon", "membrane", "destabilization", "lysosomes", "release", "C0007428#ent", "<e1>", "that", "are", "endowed", "with", "the", "capacity", "of", "triggering", "C0919336#ent", "<e2>", "."], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "transductions", "with", "these", "and", "other", "mutants", "indicate", "that", "the", "C1417679#ent", "<e1>", "encoding", "glutamate", "synthase", "glutamate", "dehydrogenase", "glutamine", "synthetase", "and", "C0008855#ent", "<e2>", "not", "closely", "linked", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008855", "name": "C0008855#ent", "pos": [21, 22]}}
{"token": ["Hepatocellular", "carcinoma", "represents", "the", "final", "step", "of", "the", "effects", "of", "various", "precipitating", "agents", "C0162532#ent", "<e1>", "such", "as", "alcohol", ",", "drugs", ",", "hormones", ",", "and", "C0019196#ent", "<e2>"], "h": {"id": "C0162532", "name": "C0162532#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019196", "name": "C0019196#ent", "pos": [24, 25]}}
{"token": ["We", "analyzed", "the", "relationship", "between", "HFE", "mutations", "and", "biochemical", "abnormalities", "C0162532#ent", "<e1>", "the", "interaction", "with", "other", "triggering", "factors", "of", "C0162532#ent", "<e1>", "alcohol", "abuse", "C0019196#ent", "<e1>", "drugs", ")", "."], "h": {"id": "C0162532", "name": "C0162532#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019196", "name": "C0019196#ent", "pos": [23, 24]}}
{"token": ["A", "membrane-associated", "complex", "of", "the", "Vps15", "protein", "kinase", "the", "C2936442#ent", "<e1>", "PtdIns", "3-kinase", "is", "essential", "for", "the", "delivery", "of", "C0086376#ent", "<e2>", "to", "the", "yeast", "vacuole"], "h": {"id": "C2936442", "name": "C2936442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["However", ",", "gastric", "cancer", "growth", "retardation", "C0010054#ent", "<e1>", "among", "other", "sequelae", "of", "this", "C0151317#ent", "<e2>"], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151317", "name": "C0151317#ent", "pos": [13, 14]}}
{"token": ["C1823919#ent", "<e1>", "is", "capable", "of", "interacting", "with", "NSP3", "in", "vivo", "during", "C0035869#ent", "<e2>"], "h": {"id": "C1823919", "name": "C1823919#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035869", "name": "C0035869#ent", "pos": [11, 12]}}
{"token": ["Cycloguanil", ",", "the", "active", "metabolite", "the", "C0003374#ent", "<e1>", "is", "an", "inhibitor", "of", "dihydrofolate", "reductase", "is", "another", "antimalarial", ",", "C0034283#ent", "<e2>", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [6, 7]}, "relation": "therapeutic_class_of", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [18, 19]}}
{"token": ["The", "anti-plasmodial", "effect", "of", "neem", "components", "was", "also", "observed", "on", "parasites", "previously", "shown", "to", "be", "resistant", "to", "other", "C0003374#ent", "<e1>", "i.e.", "chloroquine", "and", "C0034283#ent", "<e2>", "suggesting", "a", "different", "mode", "of", "action", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [18, 19]}, "relation": "therapeutic_class_of", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [23, 24]}}
{"token": ["The", "major", "complications", "were", "C0575059#ent", "<e1>", "and", "lower", "C0271375#ent", "<e2>", "tumors", "in", "anterior", "locations", ",", "and", "minor", "complications", "for", "posterior", "locations", "."], "h": {"id": "C0575059", "name": "C0575059#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0271375", "name": "C0271375#ent", "pos": [8, 9]}}
{"token": ["Structural", "and", "functional", "similarities", "to", "skeletal", "muscle", "tropomyosin", "demonstrated", "with", "respect", "to", "the", "formation", "and", "periodicity", "of", "paracrystals", "and", "C1423506#ent", "<e1>", "and", "the", "potentiation", "of", "skeletal", "muscle", "ATPase", "activity", "low", "C1705556#ent", "<e2>", "concentration", "."], "h": {"id": "C1423506", "name": "C1423506#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [30, 31]}}
{"token": ["Subgroup", "analysis", "for", "C2936882#ent", "<e1>", "versus", "C2936882#ent", "<e1>", "plus", "progestin", "revealed", "no", "differences", "for", "C1854580#ent", "<e1>", "and", "IMT", ";", "DC", ",", "however", ",", "was", "greater", "in", "estrogen-only", "users", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1854580", "name": "C1854580#ent", "pos": [14, 15]}}
{"token": ["Conversely", ",", "C0003286#ent", "<e1>", "may", "influence", "the", "dosage", "requirements", "of", "C0003280#ent", "<e2>", "inducing", "their", "metabolism", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [10, 11]}}
{"token": ["Although", "the", "fundamental", "mechanism(s", ")", "responsible", "for", "C0206146#ent", "<e1>", "not", "been", "elucidated", ",", "in", "experimental", "preparations", "C1562036#ent", "<e2>", "free-radical", "scavengers", "and", "neutrophil", "depletion", "each", "been", "found", "to", "be", "helpful", "in", "minimizing", "it", "."], "h": {"id": "C0206146", "name": "C0206146#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1562036", "name": "C1562036#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "a", "plasmid", "containing", "a", "dihydrofolate", "reductase", "C0039667#ent", "<e1>", ")", "gene", "as", "well", "as", "neoR", "and", "C1415481#ent", "<e2>", "been", "used", "to", "amplify", "and", "express", "beta", "globin", "mRNA", "in", "MELC", "."], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415481", "name": "C1415481#ent", "pos": [18, 19]}}
{"token": ["This", "unit", "consists", "of", "the", "SV40", "early", "gene", "promoter", ",", "a", "complete", "C0039667#ent", "<e1>", "coding", "sequence", "splice", "and", "polyadenylation", "sites", "a", "rabbit", "C1415481#ent", "<e2>"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415481", "name": "C1415481#ent", "pos": [22, 23]}}
{"token": ["The", "maximum", "response", "to", "C2713581#ent", "<e1>", "occurred", "with", "C1705556#ent", "<e2>", "and", "GTP", "at", "concentrations", "above", "0.30", "mM", "and", "2", "microM", ",", "respectively", "."], "h": {"id": "C2713581", "name": "C2713581#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [8, 9]}}
{"token": ["Biopsy", "specimens", "C0036421#ent", "<e1>", "lesions", "showed", "increased", "and", "thickened", "dermal", "collagen", "consistent", "with", "C0036420#ent", "<e2>", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036420", "name": "C0036420#ent", "pos": [13, 14]}}
{"token": ["He", "went", "on", "to", "develop", "symptomatic", "C0037769#ent", "<e1>", "were", "controlled", "by", "the", "addition", "of", "C0009011#ent", "<e2>", "."], "h": {"id": "C0037769", "name": "C0037769#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009011", "name": "C0009011#ent", "pos": [14, 15]}}
{"token": ["The", "patient", "was", "a", "2", "year", "old", "girl", "presenting", "C0037769#ent", "<e1>", "non", "responsive", "the", "clinical", "treatment", "vigabatrin", ",", "trileptal", "and", "C0009011#ent", "<e2>", ",", "and", "undergoing", "left", "frontal", "lobectomy"], "h": {"id": "C0037769", "name": "C0037769#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009011", "name": "C0009011#ent", "pos": [20, 21]}}
{"token": ["Molecular", ",", "virologic", ",", "and", "serologic", ",", "and", "diagnostic", "assays", "used", "to", "detect", "evidence", "of", "C0276180#ent", "<e1>", "(", "or", "orthopox", ")", "C0042769#ent", "<e2>", "individuals", "with", "striking", "dermatologic", "and", "other", "clinical", "manifestations"], "h": {"id": "C0276180", "name": "C0276180#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [21, 22]}}
{"token": ["These", "lipid", "vacuoles", "not", "seen", "in", "control", "cells", "in", "cells", "infected", "with", "C0276180#ent", "<e1>", "MPV", ")", "but", "were", "seen", "during", "C0042769#ent", "<e2>", "the", "presence", "of", "cytosine", "arabinofuranoside", "100", "microgram/ml", ")", "."], "h": {"id": "C0276180", "name": "C0276180#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [20, 21]}}
{"token": ["C0276180#ent", "<e1>", "or", "simian", "smallpox", "a", "C0042769#ent", "<e2>", "clinical", "manifestations", "similar", "to", "the", "human", "smallpox"], "h": {"id": "C0276180", "name": "C0276180#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [6, 7]}}
{"token": ["These", "data", "demonstrate", "the", "contribution", "of", "attenuated", "vascular", "reactivities", "to", "C0237795#ent", "<e1>", "substances", "as", "well", "as", "a", "diuretic", "action", "the", "antihypertensive", "effect", "C0071132#ent", "<e2>", "during", "its", "long-term", "administration", "in", "SHR", "rats", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0071132", "name": "C0071132#ent", "pos": [22, 23]}}
{"token": ["In", "other", "C0012634#ent", "<e1>", "such", "as", "respiratory", "distress", "C1418648#ent", "<e2>", "reduced", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418648", "name": "C1418648#ent", "pos": [8, 9]}}
{"token": ["A", "major", "constituent", "of", "green", "tea", "catechins", "(-)-epigallocatechin", "gallate", "EGCG", ")", ",", "inhibited", "the", "gelatinolytic", "activity", "of", "MMP-2", "and", "concanavalin", "A", "C0526871#ent", "<e1>", "activation", "without", "the", "influence", "of", "C0769218#ent", "<e2>", "MMP", "expression", "in", "SMCs", "."], "h": {"id": "C0526871", "name": "C0526871#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0769218", "name": "C0769218#ent", "pos": [28, 29]}}
{"token": ["C0014582#ent", "<e1>", "binds", "to", "C1328053#ent", "<e2>", "with", "a", "Km", "of", "approximately", "5", "microM", ",", "as", "calculated", "from", "both", "eNOS-dependent", "NADPH", "consumption", "and", "superoxide", "generation"], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [4, 5]}}
{"token": ["C0915142#ent", "<e1>", "provided", "a", "lower", "pain", "sedation", "scores", "lesser", "meperidine", "consumption", "than", "C0040610#ent", "<e2>", "for", "post-appendectomy", "pain", "."], "h": {"id": "C0915142", "name": "C0915142#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040610", "name": "C0040610#ent", "pos": [12, 13]}}
{"token": ["C0282527#ent", "<e1>", "diagnosed", "in", "three", "male", "patients", ",", "presenting", "with", "facial", "dysmorphia", "C0035334#ent", "<e2>", "neurosensory", "hearing", "loss", "hepatomegaly", ",", "osteopenia", "and", "delayed", "growth", "and", "psychomotor", "development"], "h": {"id": "C0282527", "name": "C0282527#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [12, 13]}}
{"token": ["These", "inhibitors", "of", "thiobenzamide", "sulfoxidation", "include", "C0025644#ent", "<e1>", ",", "cysteamine", ",", "and", "C0077172#ent", "<e2>", "."], "h": {"id": "C0025644", "name": "C0025644#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0077172", "name": "C0077172#ent", "pos": [12, 13]}}
{"token": ["Further", "study", "is", "necessary", "to", "evaluate", "the", "efficacy", "of", "a", "fusion", "in", "controlling", "C0740418#ent", "<e1>", "the", "postdecompressed", "patient", "with", "C0038016#ent", "<e2>"], "h": {"id": "C0740418", "name": "C0740418#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038016", "name": "C0038016#ent", "pos": [19, 20]}}
{"token": ["We", "present", "the", "case", "of", "a", "38-year-old", "woman", "with", "no", "previous", "history", "of", "coronary", "heart", "diseases", "who", "suffered", "from", "C0009088#ent", "<e1>", "had", "undergone", "a", "subcutaneous", "C0075632#ent", "<e2>", "treatment", "for", "two", "years", "."], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0075632", "name": "C0075632#ent", "pos": [25, 26]}}
{"token": ["As", "SLC6A8", "does", "not", "contain", "a", "putative", "C1420010#ent", "<e1>", "consensus", "motif", "the", "mechanism", "linking", "C1528301#ent", "<e2>", "with", "SLC6A8", "activity", "remained", "elusive", "."], "h": {"id": "C1420010", "name": "C1420010#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1528301", "name": "C1528301#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "demonstrate", "that", "heparin", "inhibits", "the", "expression", "of", "the", "early", "response", "C1420010#ent", "<e1>", "serum", "and", "C1528301#ent", "<e2>", "."], "h": {"id": "C1420010", "name": "C1420010#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1528301", "name": "C1528301#ent", "pos": [16, 17]}}
{"token": ["Adverse", "events", "reported", "more", "frequently", "with", "C0022251#ent", "<e1>", "dinitrate", "than", "with", "C0051696#ent", "<e2>", "(", "P", "<", "0.02", ")", "."], "h": {"id": "C0022251", "name": "C0022251#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [11, 12]}}
{"token": ["The", "interactions", "of", "sulfonylureas", "and", "a", "novel", "C0935929#ent", "<e1>", "nateglinide", ",", "with", "rat", "renal", "organic", "anion", "transporter", "C1705846#ent", "<e2>", ")", "expressed", "in", "Xenopus", "laevis", "oocytes", "were", "studied", "."], "h": {"id": "C0935929", "name": "C0935929#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705846", "name": "C1705846#ent", "pos": [17, 18]}}
{"token": ["This", "study", "was", "performed", "in", "patients", "with", "C0022104#ent", "<e1>", "symptoms", "of", "diarrhea", "to", "further", "assess", "the", "safety", "of", "C0537147#ent", "<e2>", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0537147", "name": "C0537147#ent", "pos": [18, 19]}}
{"token": ["Genetic", "polymorphisms", "analyzed", "in", "87", "patients", "and", "96", "controls", ",", "then", "41", "C0022104#ent", "<e1>", "patients", "with", "constipation", "received", "C0537147#ent", "<e2>", "for", "4", "weeks", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0537147", "name": "C0537147#ent", "pos": [18, 19]}}
{"token": ["The", "behaviour", "of", "C1416804#ent", "<e1>", "was", "examined", "in", "C0276622#ent", "<e2>", "post-hepatic", "cirrhosis"], "h": {"id": "C1416804", "name": "C1416804#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0276622", "name": "C0276622#ent", "pos": [8, 9]}}
{"token": ["Raised", "concentrations", "in", "patients", "with", "C0156147#ent", "<e1>", "further", "evidence", "for", "in", "vivo", "C1337091#ent", "<e2>", "in", "this", "disease", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "the", "presence", "of", "aperistalsis", "or", "multiple", "simultaneous", "contractions", "in", "the", "oesophagus", "does", "correlate", "with", "C0011168#ent", "<e1>", "and", "is", "independent", "of", "C3160718#ent", "<e2>", "severity", "or", "duration", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [23, 24]}}
{"token": ["No", "satisfactory", "drug", "therapy", "for", "the", "treatment", "of", "C0035435#ent", "<e1>", "though", "the", "use", "of", "local", "injections", "of", "C0077004#ent", "<e2>", "modified", "the", "prognosis", "of", "pauciarticular", "JCA", "."], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0077004", "name": "C0077004#ent", "pos": [17, 18]}}
{"token": ["These", "additional", "bands", "of", "C0034348#ent", "<e1>", "electrophoretically", "and", "immunologically", "similar", "to", "the", "C2698922#ent", "<e2>", "in", "adult", "erythrocytes", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [4, 5]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C2698922", "name": "C2698922#ent", "pos": [12, 13]}}
{"token": ["Tobacco", "plants", "transformed", "with", "a", "cDNA", "clone", "C0596337#ent", "<e1>", "PI2", ")", "under", "the", "control", "of", "a", "C0669365#ent", "<e2>", "promoter", "."], "h": {"id": "C0596337", "name": "C0596337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "it", "is", "increasingly", "recognized", "as", "a", "cause", "of", "devastating", "or", "fatal", "C0023048#ent", "<e1>", "infants", "and", "young", "children", "and", "C0028848#ent", "<e2>", "adults", "."], "h": {"id": "C0023048", "name": "C0023048#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0028848", "name": "C0028848#ent", "pos": [21, 22]}}
{"token": ["We", "detected", "increased", "C0669372#ent", "<e1>", "expression", "of", "C1539477#ent", "<e2>", ",", "Fas", "ligand", "FasL", ")", ",", "and", "CD40", "associated", "with", "of", "centrilobular", "(", "acinar", "zone", "3", "hepatocytes", "in", "chronic", "allograft", "rejection"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [7, 8]}}
{"token": ["3", ")", "The", "SP", "analogue", "in", "which", "Gly9", "is", "replaced", "with", "sarcosine", "(", "C0268563#ent", "<e1>", ")", "is", "not", "hydrolyzed", "by", "C1420247#ent", "<e2>", "(", "kc/Km", "less", "than", "3", "M-1", "s-1", ")", "."], "h": {"id": "C0268563", "name": "C0268563#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420247", "name": "C1420247#ent", "pos": [20, 21]}}
{"token": ["We", "examined", "whether", "Na(+)-dependent", "glucose", "transporter", "C2699249#ent", "<e1>", ")", "interacts", "with", "C1415760#ent", "<e2>", "to", "elevate", "C2699249#ent", "<e1>", "activity", "and", "whether", "C2699249#ent", "<e1>", "activation", "is", "involved", "in", "the", "recovery", "from", "HS", "injury"], "h": {"id": "C2699249", "name": "C2699249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "whether", "sodium-dependent", "glucose", "transporter", "C2699249#ent", "<e1>", ")", "interacts", "with", "C1415760#ent", "<e2>", "to", "increase", "C2699249#ent", "<e1>", "activity", "."], "h": {"id": "C2699249", "name": "C2699249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [11, 12]}}
{"token": ["Yet", ",", "no", "previous", "studies", "examined", "C0812246#ent", "<e1>", "expression", "in", "C0018989#ent", "<e2>", "skeletal", "muscle"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "suggest", "that", "GGA", "may", "have", "a", "potential", "benefit", "for", "the", "prevention", "of", "C0400807#ent", "<e1>", "chronically", "or", "critically", "ill", "patients", "with", "C0022806#ent", "<e2>"], "h": {"id": "C0400807", "name": "C0400807#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0022806", "name": "C0022806#ent", "pos": [22, 23]}}
{"token": ["Animals", "were", "given", "sciatic", "nerve", "injections", "with", "0", "-", "80", "mM", "C0013085#ent", "<e1>", ",", "amitriptyline", ",", "or", "C0887621#ent", "<e2>", "(", "1.5", "mL", "for", "histological", "studies", "0.3", "mL", "for", "neurobehavioral", "studies", ")", "."], "h": {"id": "C0013085", "name": "C0013085#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0887621", "name": "C0887621#ent", "pos": [17, 18]}}
{"token": ["Forty-five", "patients", "with", "C0020538#ent", "<e1>", "treated", "for", "2", "months", "with", "either", "metoprolol", "or", "C0031937#ent", "<e2>", "in", "a", "randomized", ",", "blind", ",", "crossover", "study"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031937", "name": "C0031937#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "SSS", "who", "require", "beta-blocker", "therapy", "tachycardia", ",", "C0020538#ent", "<e1>", "angina", "pectoris", "have", "less", "bradycardia", "when", "treated", "with", "C0031937#ent", "<e2>", "rather", "than", "propranolol", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0031937", "name": "C0031937#ent", "pos": [19, 20]}}
{"token": ["In", "a", "double-blind", "study", "patients", "with", "mild", "and", "uncomplicated", "C0020538#ent", "<e1>", "randomized", "to", "treatment", "with", "either", "C0031937#ent", "<e2>", "10", "mg", "or", "atenolol", "100", "mg", "once", "daily", "for", "4", "weeks", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0031937", "name": "C0031937#ent", "pos": [16, 17]}}
{"token": ["Loss", "or", "dysfunction", "of", "C3889435#ent", "<e1>", "or", "PC2", "may", "therefore", "lead", "to", "C1868682#ent", "<e2>", "owing", "to", "the", "inability", "of", "cells", "to", "sense", "mechanical", "cues", "that", "normally", "regulate", "tissue", "morphogenesis"], "h": {"id": "C3889435", "name": "C3889435#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1868682", "name": "C1868682#ent", "pos": [12, 13]}}
{"token": ["C3540727#ent", "<e1>", "are", "the", "principal", "cause", "of", "C0029456#ent", "<e2>", "to", "drug", "treatment"], "h": {"id": "C3540727", "name": "C3540727#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029456", "name": "C0029456#ent", "pos": [7, 8]}}
{"token": ["The", "PTP", "catalytic", "domain", "45", "-", "50", "%", "sequence", "identity", "with", "the", "catalytic", "domain", "human", "C1419114#ent", "<e1>", "beta", "and", "with", "the", "first", "catalytic", "domain", "C1413510#ent", "<e2>", "."], "h": {"id": "C1419114", "name": "C1419114#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1413510", "name": "C1413510#ent", "pos": [24, 25]}}
{"token": ["The", "second", "had", "central", "hypocorticism", ",", "C3665349#ent", "<e1>", "and", "hypogonadism", "associated", "with", "C0011848#ent", "<e2>", "hyperprolactinemia", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [12, 13]}}
{"token": ["The", "eruption", "usually", "occurs", "in", "individuals", "with", "C0013595#ent", "<e1>", "other", "pre-existing", "dermatosis", "such", "as", "Darier's", "disease", "C0263313#ent", "<e2>", "mycosis", "fungoides", "Sezary", "syndrome", "benign", "familial", "pemphigus", "ichthyosis", "vulgaris", "second-degree", "burns", "multiple", "myeloma", "and", "Grover's", "disease"], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0263313", "name": "C0263313#ent", "pos": [16, 17]}}
{"token": ["Some", "patients", "with", "recurrent", "C0040425#ent", "<e1>", "not", "suffered", "from", "C0035086#ent", "<e2>", "implying", "that", "it", "is", "possible", "to", "find", "a", "balance", "between", "immunity", "and", "tolerance", "."], "h": {"id": "C0040425", "name": "C0040425#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [9, 10]}}
{"token": ["The", "authors", "provide", "the", "clinico-morphologic", "evidence", "for", "amyloid", "resorption", "patients", "with", "C0031090#ent", "<e1>", "amyloidosis", "under", "the", "effect", "of", "C0009262#ent", "<e2>", "."], "h": {"id": "C0031090", "name": "C0031090#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [18, 19]}}
{"token": ["The", "obtained", "2,392", "bp", "human", "C3541254#ent", "<e1>", "cDNA", "encodes", "a", "predicted", "open", "reading", "frame", "of", "326", "C3539947#ent", "<e2>"], "h": {"id": "C3541254", "name": "C3541254#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [16, 17]}}
{"token": ["2-(Allylthio)pyrazine", "(", "2-AP", ")", ",", "synthesized", "for", "its", "possible", "use", "as", "a", "C1512412#ent", "<e1>", "has", "been", "found", "to", "selectively", "inhibit", "rat", "C0010763#ent", "<e2>", "Kim", "et", "al.", ",", "Biochem", "."], "h": {"id": "C1512412", "name": "C1512412#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [21, 22]}}
{"token": ["These", "results", "lead", "us", "to", "speculate", "that", "propolis", "may", "play", "C1512412#ent", "<e1>", "role", "via", "improved", "C0010763#ent", "<e2>", "activity", "and", "reduced", "oxidative", "stress", "living", "system"], "h": {"id": "C1512412", "name": "C1512412#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [15, 16]}}
{"token": ["I", "chose", "to", "examine", "C0015397#ent", "<e1>", "ailments", "such", "as", "cataracts", ",", "glaucoma", ",", "C0034951#ent", "<e2>", "and", "diabetic", "retinopathy", "rank", "among", "the", "most", "serious", "diseases", "of", "Indian", "women", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0034951", "name": "C0034951#ent", "pos": [13, 14]}}
{"token": ["After", "SP", ",", "the", "NKA", "concentration", "was", "highest", "and", "NKB", "concentration", "was", "lowest", "in", "all", "regions", "except", "for", "the", "C0001614#ent", "<e1>", "and", "hippocampus", "where", "the", "C1420563#ent", "<e2>", "concentration", "was", "highest", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420563", "name": "C1420563#ent", "pos": [25, 26]}}
{"token": ["The", "overexpression", "of", "C1412459#ent", "<e1>", "completely", "abolishes", "the", "activation", "of", "a", "key", "S", "phase", "gene", "the", "C1366824#ent", "<e2>", "TS", ")", "gene", ",", "driven", "by", "the", "transcription", "factor", "LSF/CP2/LBP1", "(", "LSF", ")", "."], "h": {"id": "C1412459", "name": "C1412459#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366824", "name": "C1366824#ent", "pos": [16, 17]}}
{"token": ["Eleven", "patients", "did", "not", "have", "deficient", "enzyme", "activity", "11", "parents", "did", "not", "have", "intermediate", "C0014442#ent", "<e1>", "activities", "compatible", "with", "heterozygosity", "for", "C0268483#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0268483", "name": "C0268483#ent", "pos": [21, 22]}}
{"token": ["Fumarylacetoacetate", "hydrolase", "FAH", ")", "is", "an", "C0014442#ent", "<e1>", "which", "is", "deficient", "in", "human", "C0268483#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268483", "name": "C0268483#ent", "pos": [13, 14]}}
{"token": ["The", "three-dimensional", "structure", "C0072530#ent", "<e1>", ",", "a", "single", "C0019587#ent", "<e2>", "Alcaligenes", "faecalis", "strain", "S-6", "has", "been", "determined", "at", "2.9", "A", "resolution", "by", "X-ray", "crystallography"], "h": {"id": "C0072530", "name": "C0072530#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019587", "name": "C0019587#ent", "pos": [8, 9]}}
{"token": ["Single", "nucleotide", "polymorphisms", "C0058126#ent", "<e1>", "DPYD", ")", "induces", "C1366555#ent", "<e2>", "DPD", ")", "deficiency", "resulting", "in", "increased", "activity", "of", "5-fluorouracil", "derivatives"], "h": {"id": "C0058126", "name": "C0058126#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366555", "name": "C1366555#ent", "pos": [8, 9]}}
{"token": ["Mutations", "in", "the", "C0058126#ent", "<e1>", "which", "encodes", "C1366555#ent", "<e2>", "DPD", ")", ",", "the", "rate-limiting", "enzyme", "in", "the", "catabolism", "of", "pyrimidines", ",", "are", "responsible", "for", "an", "inborn", "error", "metabolism", "associated", "with", "thymine-uraciluria", "and", "neurological", "symptoms"], "h": {"id": "C0058126", "name": "C0058126#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366555", "name": "C1366555#ent", "pos": [7, 8]}}
{"token": ["We", "hypothesized", "that", "C0549410#ent", "<e1>", "an", "inflammatory", "phenomenon", "by", "the", "overexpression", "of", "C0387583#ent", "<e2>", "COX-2", ")", "."], "h": {"id": "C0549410", "name": "C0549410#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [12, 13]}}
{"token": ["Additional", "tests", "revealed", "that", "distinct", "structural", "motifs", "of", "C3889143#ent", "<e1>", "direct", "interaction", "with", "C1416662#ent", "<e2>", "and", "shuttling", "between", "the", "nucleus", "and", "cytoplasm", "of", "asynchronously", "cycling", "cells"], "h": {"id": "C3889143", "name": "C3889143#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416662", "name": "C1416662#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "a", "yeast", "two-hybrid", "screen", "C1416662#ent", "<e1>", "cofactors", "in", "the", "developing", "nervous", "system", "a", "novel", "140-kDa", "protein", "named", "C3889143#ent", "<e2>", ",", "for", "modulator", "of", "C1416662#ent", "<e1>", "activity", "."], "h": {"id": "C3889143", "name": "C3889143#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1416662", "name": "C1416662#ent", "pos": [6, 7]}}
{"token": ["These", "C3653288#ent", "<e1>", "inhibited", "the", "serine", "proteinases", "trypsin", "C0752224#ent", "<e2>", "with", "similar", "efficiency", "but", "did", "not", "inhibit", "plasmin", "(", "a", "serine", "proteinase", "or", "papain", "(", "a", "thiol", "proteinase", "."], "h": {"id": "C3653288", "name": "C3653288#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0752224", "name": "C0752224#ent", "pos": [8, 9]}}
{"token": ["Three", "structural", "proteins", "five", "virus-specific", "nonstructural", "proteins", "were", "detectable", "in", "C0014060#ent", "<e1>", "virus-infected", "BHK", "cells", "treated", "with", "C3536807#ent", "<e2>", "and", "pulse-inhibited", "with", "cycloheximide", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536807", "name": "C3536807#ent", "pos": [17, 18]}}
{"token": ["Groups", "of", "9", "nude", "mice", "bearing", "HT29", "xenografts", "were", "treated", "with", "single", "agent", "C0950968#ent", "<e1>", ",", "C0594375#ent", "<e2>", ",", "or", "5FU", ",", "or", "C0950968#ent", "<e1>", "in", "combination", "with", "C0594375#ent", "<e2>", "or", "5FU", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0950968", "name": "C0950968#ent", "pos": [13, 14]}}
{"token": ["C0080323#ent", "<e1>", ",", "khellin", ",", "and", "C0078355#ent", "<e2>", "were", "identified", "and", "determined", "as", "the", "effective", "principles", "in", "this", "testing", "model", "the", "dihydropyranocoumarin", "visnadin", "being", "the", "most", "active", "."], "h": {"id": "C0080323", "name": "C0080323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0078355", "name": "C0078355#ent", "pos": [6, 7]}}
{"token": ["This", "C1422492#ent", "<e1>", ",", "which", "contains", "multiple", "tetratricopeptide", "repeat", "C1420877#ent", "<e2>", ")", "motifs", "from", "amino", "acid", "aa", ")", "294", ",", "is", "identical", "to", "a", "component", "of", "U5", "small", "nuclear", "ribonucleoprotein", "particles", "binds", "specifically", "to", "the", "AR", "or", "glucocorticoid", "receptor"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420877", "name": "C1420877#ent", "pos": [9, 10]}}
{"token": ["The", "C1254351#ent", "<e1>", "was", "well", "tolerated", "with", "C0012833#ent", "<e2>", "lethargy", "being", "reported", "more", "commonly", "than", "with", "placebo", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012833", "name": "C0012833#ent", "pos": [7, 8]}}
{"token": ["When", "cells", "were", "C0281567#ent", "<e1>", "at", "0.5", "Hz", ",", "C0039902#ent", "<e2>", "myocyte", "relengthening", "and", "the", "fall", "in", "intracellular", "[", "Ca2", "+", "]", "were", "slowed", "when", "compared", "with", "cells", "from", "age-matched", "WT", "controls"], "h": {"id": "C0281567", "name": "C0281567#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [9, 10]}}
{"token": ["In", "situ", "hybridization", "tissue", "sections", "the", "expression", "of", "C1417679#ent", "<e1>", "coding", "for", "granzyme", "A", "C1567160#ent", "<e2>", "the", "thymus", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1567160", "name": "C1567160#ent", "pos": [14, 15]}}
{"token": ["This", "phosphorylation", "increases", "the", "transcriptional", "activity", "MITF", "and", "STAT3", "as", "indicated", "by", "mRNA", "accumulation", "of", "their", "target", "C1417679#ent", "<e1>", "such", "as", "Bcl-2", ",", "C1567160#ent", "<e2>", "and", "c-Myc", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1567160", "name": "C1567160#ent", "pos": [23, 24]}}
{"token": ["The", "co-administration", "of", "C0700541#ent", "<e1>", "with", "the", "induction", "of", "C0877017#ent", "<e2>", "ECS", ")", "was", "evaluated", "as", "a", "possible", "method", "for", "reducing", "the", "impact", "of", "ECS", "on", "hippocampal", "synaptic", "plasticity", "in", "rats", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0877017", "name": "C0877017#ent", "pos": [9, 10]}}
{"token": ["The", "vascular", "effects", "cyclooxygenase", "(", "COx", ")", "blockade", "(", "C0700583#ent", "<e1>", "intravenously", ")", "and", "the", "subsequent", "vasoconstrictor", "response", "endothelin-1", "(", "C3273436#ent", "<e2>", ")", "infusion", "30", "min", "after", "C0700583#ent", "<e1>", "were", "studied", "in", "healthy", "men", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [20, 21]}}
{"token": ["The", "effects", "of", "cyclo-oxygenase", "pathway", "inhibition", "by", "C0700583#ent", "<e1>", "on", "the", "endotoxin", "shock", "response", "and", "C3273436#ent", "<e2>", "turnover", ",", "were", "investigated", "in", "five", "groups", "of", "pigs", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [15, 16]}}
{"token": ["Sulfasalazine", "and", "C3540725#ent", "<e1>", ",", "the", "two", "cornerstones", "of", "past", "therapy", ",", "are", "now", "joined", "by", "the", "C0127615#ent", "<e2>", "drugs", ",", "antibiotics", ",", "immunosuppressive", "agents", "and", "newer", "C3540725#ent", "<e1>", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [2, 3]}}
{"token": ["Furthermore", ",", "cerebral", "mRNA", "expression", "of", "the", "growth", "factors", "IGF1", ",", "FGF2", ",", "TGFbeta1", ",", "EGF", "and", "C1335200#ent", "<e1>", "was", "significantly", "elevated", "after", "C1418943#ent", "<e2>", "."], "h": {"id": "C1335200", "name": "C1335200#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [23, 24]}}
{"token": ["C0525005#ent", "<e1>", "(", "Viracept", ")", "is", "an", "orally", "administered", "C0033607#ent", "<e2>"], "h": {"id": "C0525005", "name": "C0525005#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [9, 10]}}
{"token": ["In", "whole", "blood", "cultures", "T", "cell", "proliferation", "multiple", "sclerosis", "C0026769#ent", "<e1>", ")", "patients", ",", "using", "soluble", "CD3", "mAb", "CD2", "mAb", "C0304402#ent", "<e2>", ",", "was", "reduced", "in", "comparison", "to", "healthy", "controls"], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "suggest", "that", "C0063033#ent", "<e1>", "be", "beneficial", "in", "the", "treatment", "of", "C0752304#ent", "<e2>", "neonates", "."], "h": {"id": "C0063033", "name": "C0063033#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752304", "name": "C0752304#ent", "pos": [12, 13]}}
{"token": ["Overexpression", "of", "C1422096#ent", "<e1>", "promotes", "poly-ubiquitination", "of", "C1413935#ent", "<e2>", "protein", "turnover", "p150(Glued", ")", "."], "h": {"id": "C1422096", "name": "C1422096#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413935", "name": "C1413935#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "the", "enhanced", "C0752312#ent", "<e1>", "phosphorylation", "following", "amino", "acid", "deprivation", "required", "GCN2", "kinase", "activity", "and", "C1414334#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414334", "name": "C1414334#ent", "pos": [16, 17]}}
{"token": ["The", "latter", "would", "be", "compatible", "with", "a", "sporadic", "presentation", "C0022471#ent", "<e1>", "or", "multigenic", "expression", "heredity", "in", "C0030779#ent", "<e2>", "."], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [16, 17]}}
{"token": ["C0002651#ent", "<e1>", "binds", "preferentially", "and", "specifically", "to", "the", "cytoplasmic", "surface", "the", "C1420193#ent", "<e2>"], "h": {"id": "C0002651", "name": "C0002651#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [11, 12]}}
{"token": ["C0008269#ent", "<e1>", "and", "SP", "are", "completely", "ineffective", "for", "the", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "in", "northern", "Myanmar", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [11, 12]}}
{"token": ["Previous", "investigations", "had", "shown", "that", "resistance", "to", "standard", "regimens", "C0008269#ent", "<e1>", "occurred", "in", "some", "cases", "of", "C0024535#ent", "<e2>", "the", "Philippines", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [16, 17]}}
{"token": ["We", "conclude", "that", "amodiaquine", "is", "not", "a", "suitable", "replacement", "for", "C0008269#ent", "<e1>", "for", "treating", "C0024535#ent", "<e2>", "malaria", "in", "our", "study", "area", "in", "vitro", "sensitivity", "data", "suggesting", "that", "it", "would", "be", "efficacious", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrated", "that", "the", "expression", "of", "neurogenin", "3", "ngn3", ")", ",", "an", "islet-", "and", "neuron-specific", "C1420632#ent", "<e1>", "partially", "overlaps", "that", "of", "C3273872#ent", "<e2>", "during", "early", "mouse", "development"], "h": {"id": "C1420632", "name": "C1420632#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [21, 22]}}
{"token": ["Overexpression", "of", "hippocalcin", "dramatically", "elongated", "neurites", "and", "increased", "the", "expression", "of", "basic", "C1420632#ent", "<e1>", "that", "is", ",", "C3273872#ent", "<e2>", "without", "bFGF", "stimulation", "."], "h": {"id": "C1420632", "name": "C1420632#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [17, 18]}}
{"token": ["The", "combined", "application", "of", "ketamine", "with", "C0017887#ent", "<e1>", "sodium", "nitroprusside", "indicated", "in", "the", "event", "of", "pulmonary", "or", "C0020538#ent", "<e2>"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [17, 18]}}
{"token": ["Chemical", "and", "short", "interfering", "RNA", "inhibition", "of", "GSK-3beta", "and", "C1442788#ent", "<e1>", "individually", "and", "in", "combination", "revealed", "that", "both", "C0031727#ent", "<e2>", "follow", "the", "same", "pathway", "to", "regulate", "nuclear", "export", "Nrf2", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}}
{"token": ["C3273878#ent", "<e1>", ",", "the", "gene", "responsible", "for", "autosomal", "dominant", "C0338508#ent", "<e2>", "represents", "a", "good", "candidate", "gene", "for", "normal-tension", "glaucoma", "NTG", ")", "."], "h": {"id": "C3273878", "name": "C3273878#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0338508", "name": "C0338508#ent", "pos": [9, 10]}}
{"token": ["CD11B-D", "are", "arranged", "in", "a", "C0017258#ent", "<e1>", "300", "kb", "and", "CD11A", "is", "located", "about", "2.5", "Mb", "C0087071#ent", "<e2>", "."], "h": {"id": "C0017258", "name": "C0017258#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0087071", "name": "C0087071#ent", "pos": [16, 17]}}
{"token": ["Several", "recent", "studies", "in", "human", "immunodeficiency", "virus", "HIV", ")", "patients", "have", "identified", "micronutrient", "C2713546#ent", "<e1>", "as", "affecting", "progression", "to", "C0001175#ent", "<e2>", "AIDS", ")", "and", "death", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [19, 20]}}
{"token": ["C1706005#ent", "<e1>", "(", "+", ")", "patients", "mostly", "presented", "with", "C0027726#ent", "<e2>", "NS", ")", "(", "n=9", ")", "and", "C1706005#ent", "<e1>", "(", "-", ")", "patients", "mostly", "with", "macroscopic", "hematuria", "n=7", ")", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [9, 10]}}
{"token": ["C1332389#ent", "<e1>", "(", "Breast", "Cancer", "Sequence", "3", ")", "is", "a", "C0017337#ent", "<e2>", "of", "unknown", "function", "on", "human", "chromosome", "17q23", "a", "region", "associated", "with", "breakpoints", "of", "several", "neoplasms", "."], "h": {"id": "C1332389", "name": "C1332389#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "we", "present", "genetic", "evidence", "suggests", "that", "C1367453#ent", "<e1>", "functions", "within", "a", "novel", "regulatory", "pathway", "facilitates", "C2917660#ent", "<e2>", "induction", "of", "the", "PTR", "system"], "h": {"id": "C1367453", "name": "C1367453#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [17, 18]}}
{"token": ["Finally", ",", "we", "describe", "the", "properties", "of", "a", "particular", "C1367453#ent", "<e1>", "mutant", "that", "suggest", "that", "Ptr3", "acts", "with", "Ssy1", "in", "C2917660#ent", "<e2>", "detection", "and", "signal", "initiation"], "h": {"id": "C1367453", "name": "C1367453#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [20, 21]}}
{"token": ["Myeloperoxidase", "activity", "increased", "in", "colons", "of", "M\u00d8/DC-depleted", ",", "DSS-treated", "mice", ",", "compared", "with", "C1848296#ent", "<e1>", "alone", ",", "coincident", "with", "increased", "neutrophil", "infiltration", "C0277565#ent", "<e2>", "colons", "."], "h": {"id": "C1848296", "name": "C1848296#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [22, 23]}}
{"token": ["It", "might", "be", "supposed", "that", "the", "species", "difference", "may", "be", "responsible", "for", "this", "difference", ",", "and", "that", "some", "C0086376#ent", "<e1>", "or", "polypeptides", "induce", "human", "sleep", ",", "especially", "C1708620#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1708620", "name": "C1708620#ent", "pos": [27, 28]}}
{"token": ["It", "did", "not", "result", "from", "alterations", "in", "C1423592#ent", "<e1>", "variants", "expression", ",", "the", "major", "FSH-regulated", "C3828567#ent", "<e2>", "in", "Sertoli", "cells"], "h": {"id": "C1423592", "name": "C1423592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3828567", "name": "C3828567#ent", "pos": [15, 16]}}
{"token": ["Intrahepatic", "cholestasis", "of", "pregnancy", "is", "characterized", "by", "C0033775#ent", "<e1>", "and", "raised", "maternal", "C0002594#ent", "<e2>", "and", "bile", "acid", "serum", "."], "h": {"id": "C0033775", "name": "C0033775#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [12, 13]}}
{"token": ["Challenge", "with", "carbimazole", "was", "followed", "within", "12", "hours", "by", "abdominal", "pain", "C0033775#ent", "<e1>", ",", "and", "increased", "C0002594#ent", "<e2>", "."], "h": {"id": "C0033775", "name": "C0033775#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [16, 17]}}
{"token": ["Significantly", ",", "replacement", "of", "the", "recruitment", "domain", "of", "the", "C0010656#ent", "<e1>", "the", "extrinsic", "apoptotic", "pathway", "caspase-8", ",", "by", "that", "of", "C1705066#ent", "<e2>", "allows", "activation", "of", "this", "hybrid", "caspase", "by", "the", "apoptosome", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705066", "name": "C1705066#ent", "pos": [20, 21]}}
{"token": ["The", "C1538681#ent", "<e1>", "response", "to", "exogenous", "LHRH", "was", "reduced", "in", "C0020676#ent", "<e2>", "rams", "but", "not", "in", "hyperthyroid", "rams", "."], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [10, 11]}}
{"token": ["It", "has", "been", "suggested", "by", "several", "authors", "that", "the", "prevalence", "of", "C0026267#ent", "<e1>", "aortic", "root", "dilation", "increased", "in", "individuals", "with", "the", "C0016667#ent", "<e2>"], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C0016667", "name": "C0016667#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "we", "suppose", "that", "these", "alterations", ",", "particularly", "the", "C0026267#ent", "<e1>", "are", "non", "casually", "associated", "with", "C0016667#ent", "<e2>"], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0016667", "name": "C0016667#ent", "pos": [17, 18]}}
{"token": ["Calyculin", "A", "an", "inhibitor", "of", "serine/threonine", "phosphatases", "C1418858#ent", "<e1>", ">", "pp2a", ")", ",", "induced", "strong", "phosphorylation", "of", "C1334146#ent", "<e2>", "in", "the", "plasma", "membrane", "not", "in", "the", "specific", "granules", "."], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334146", "name": "C1334146#ent", "pos": [17, 18]}}
{"token": ["Conversely", ",", "overexpression", "of", "C1417708#ent", "<e1>", "itself", "induced", "C1417807#ent", "<e2>", "expression", "and", "cardiomyocyte", "enlargement", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [8, 9]}}
{"token": ["The", "results", "revealed", "a", "significant", "clustering", "of", "C0382507#ent", "<e1>", "chromosome", "12", "bands", "q23-q24.3", ",", "indicating", "that", "the", "gene", "coding", "C1417547#ent", "<e2>", "is", "located", "in", "this", "region", "."], "h": {"id": "C0382507", "name": "C0382507#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417547", "name": "C1417547#ent", "pos": [19, 20]}}
{"token": ["C1705838#ent", "<e1>", "is", "a", "C0536221#ent", "<e2>", "is", "critically", "involved", "in", "the", "regulation", "of", "cell", "survival", "apoptosis", "."], "h": {"id": "C1705838", "name": "C1705838#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [4, 5]}}
{"token": ["The", "AUC(0", "-", "8", "h", ")", "of", "C0008296#ent", "<e1>", ",", "a", "metabolite", "formed", "from", "chlorzoxazone", "mainly", "by", "C3887686#ent", "<e2>", ",", "was", "significantly", "higher", "in", "the", "dark", "phase", "than", "in", "the", "light", "phase"], "h": {"id": "C0008296", "name": "C0008296#ent", "pos": [7, 8]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [17, 18]}}
{"token": ["Superfusion", "of", "both", "C0031448#ent", "<e1>", "(", "1", "microM", ")", "and", "C0724441#ent", "<e2>", "(", "1", "microM", ")", "reduced", "the", "sIPSPs", "while", "prazosin", "(", "1", "microM", ")", "had", "no", "significant", "effect", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [10, 11]}}
{"token": ["Opposite", "effects", "seen", "after", "microinjection", "of", "adrenergic", "alpha", "receptor", "antagonists", "phenoxybenzamine", ",", "C0031448#ent", "<e1>", "but", "not", "C0724441#ent", "<e2>", ")", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [16, 17]}}
{"token": ["The", "clonidine-induced", "hyperglycemia", "was", "significantly", "diminished", "by", "C0031448#ent", "<e1>", "and", "only", "partly", "by", "C0724441#ent", "<e2>", ",", "whereas", "phenoxybenzamine", "was", "ineffective", "here", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [13, 14]}}
{"token": ["Human", "mast", "cells", "divided", "into", "two", "major", "subsets", ":", "MCT", "(", "mast", "cells", "immunoreactivity", "for", "tryptase", "but", "not", "C0055673#ent", "<e1>", ")", "and", "C3890389#ent", "<e2>", "(", "reactive", "for", "tryptase", "and", "C0055673#ent", "<e1>", ")", "."], "h": {"id": "C3890389", "name": "C3890389#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [18, 19]}}
{"token": ["These", "studies", "indicate", "that", "human", "C3890389#ent", "<e1>", "mast", "cells", "contain", "two", "different", "chymotrypsin-like", "proteinases", "C0055673#ent", "<e2>", "and", "a", "proteinase", "more", "closely", "related", "to", "cathepsin", "G", "both", "of", "which", "are", "undetectable", "in", "MCT", "mast", "cells"], "h": {"id": "C3890389", "name": "C3890389#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [14, 15]}}
{"token": ["This", "technique", "demonstrated", "that", "21", "week-old", "C1516876#ent", "<e1>", "hypertensive", "rats", "from", "the", "Lyon", "strain", "(", "C1538681#ent", "<e2>", ")", "exhibited", "higher", "and", "more", "variable", "BP", "and", "dp/dt", "max"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538681", "name": "C1538681#ent", "pos": [15, 16]}}
{"token": ["C0017628#ent", "<e1>", "partially", "inhibited", "the", "relaxant", "effects", "of", "C0282211#ent", "<e2>", "(", "P<0.05", ")", "and", "salbutamol", "(", "P<0.001", ")", "but", "not", "that", "of", "SR", "59104A", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "C0017628#ent", "<e1>", "(", "10", "microM", ")", "did", "not", "affect", "the", "effects", "of", "C0282211#ent", "<e2>", "and", "fenoterol", ",", "whereas", "C0017628#ent", "<e1>", "(", "3", "microM", ")", "significantly", "inhibited", "the", "cromakalim-induced", "vasorelaxation", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [15, 16]}}
{"token": ["Blockade", "of", "ATP-sensitive", "K(+", ")", "channels", "(", "K(ATP", ")", ")", "channels", "with", "C0017628#ent", "<e1>", "significantly", "decreased", "C0282211#ent", "<e2>", "vasodilation", "in", "2K-1C", "without", "affecting", "this", "response", "in", "2", "K", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [16, 17]}}
{"token": ["The", "affinities", "of", "recognized", "nucleoside", "transport", "inhibitors", "C4048284#ent", "<e1>", "for", "these", "C0597607#ent", "<e2>", "guinea", "pig", "and", "rat", "heart", "were", "estimated", "by", "studying", "the", "inhibition", "of", "the", "site-specific", "binding", "of", "[3H]NBMPR", "in", "competition", "experiments"], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0597607", "name": "C0597607#ent", "pos": [11, 12]}}
{"token": ["The", "only", "manifestation", "of", "C0019693#ent", "<e1>", "genital", "tuberculosis", "the", "symptoms", "of", "an", "C0149959#ent", "<e2>", "which", "is", "extremely", "rare", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149959", "name": "C0149959#ent", "pos": [12, 13]}}
{"token": ["The", "succession", "or", "the", "coexistence", "of", "intermittent", "attacks", "of", "arthralgias", "and", "C0003864#ent", "<e1>", "has", "been", "pointed", "out", "as", "particular", "indications", "of", "C0242381#ent", "<e2>"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0242381", "name": "C0242381#ent", "pos": [21, 22]}}
{"token": ["To", "assess", "the", "potential", "involvement", "of", "C1522575#ent", "<e1>", "the", "hyperpermeability", "characterizing", "the", "ovarian", "hyperstimulation", "syndrome", "C0085083#ent", "<e2>", ")", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085083", "name": "C0085083#ent", "pos": [15, 16]}}
{"token": ["Two", "glycopeptide", "hydrolases", "an", "C0086215#ent", "<e1>", "and", "peptide", ":", "N-glycanase", "(", "C0051581#ent", "<e2>", ")", ",", "have", "been", "isolated", "from", "defatted", "jack", "bean", "meal", "by", "standard", "procedures", "differential", "solubility", "and", "column", "chromatography"], "h": {"id": "C0086215", "name": "C0086215#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0051581", "name": "C0051581#ent", "pos": [11, 12]}}
{"token": ["We", "also", "show", "that", "mutation", "of", "certain", "conserved", "tyrosine", "residues", "to", "glutamate", "can", "C0669365#ent", "<e1>", "activate", "the", "E3", "activity", "of", "C1707078#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1707078", "name": "C1707078#ent", "pos": [20, 21]}}
{"token": ["In", "this", "context", "of", "studies", ",", "we", "interestingly", "demonstrated", "that", "RETMEN2A", "and", "RETMEN2B", "receptors", "are", "C0669365#ent", "<e1>", "ubiquitinated", "and", "interact", "with", "the", "ubiquitin", "ligase", "C1707078#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1707078", "name": "C1707078#ent", "pos": [24, 25]}}
{"token": ["C0265253#ent", "<e1>", "SS", ")", "is", "an", "autosomal", "dominant", "C0019247#ent", "<e2>", "the", "collagenous", "connective", "tissue", "impaired", "development", "of", "the", "vitreous", "body", "gel", "peripheral", "retina", "detachment", "of", "the", "retina", "are", "associated", "with", "general", "manifestations"], "h": {"id": "C0265253", "name": "C0265253#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [8, 9]}}
{"token": ["C1413038#ent", "<e1>", "and", "CAR3", "are", "not", "required", "for", "transcription", "of", "the", "PDI", "gene", "but", "deleting", "C1413038#ent", "<e1>", "leads", "to", "C0001622#ent", "<e1>", "of", "the", "PDI", "transcript", "."], "h": {"id": "C1413038", "name": "C1413038#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [19, 20]}}
{"token": ["The", "detrimental", "effects", "C0001911#ent", "<e1>", "metabolites", "on", "male", "and", "female", "C0018889#ent", "<e2>", "were", "quickly", "reversed", "after", "withdrawal", "of", "medication", "."], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [10, 11]}}
{"token": ["Foreign", "migrant", "workers", "work", "permits", "in", "Thailand", "are", "given", "once", "a", "year", "300", "mg", "diethyl-carbamazine", "(", "DEC", ")", "for", "bancroftian", "filariasis", "and", "400", "mg", "C0001911#ent", "<e1>", "(", "ABZ", ")", "for", "C0018889#ent", "<e2>", "."], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [24, 25]}, "relation": "may_prevent", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [30, 31]}}
{"token": ["C0031659#ent", "<e1>", "a", "dimer", "comprising", "M-", ",", "B-", "and", "MB-type", "C0026794#ent", "<e2>", "composed", "from", "the", "combination", "of", "the", "muscle-specific", "(M", "and", "non-muscle-specific", "(", "B", ")", "subunits", "."], "h": {"id": "C0031659", "name": "C0031659#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026794", "name": "C0026794#ent", "pos": [10, 11]}}
{"token": ["By", "contrast", ",", "Y402F", "inhibited", "C1335273#ent", "<e1>", "Tyr(402", ")", "phosphorylation", ",", "whereas", "it", "markedly", "enhanced", "AngII-induced", "C1430595#ent", "<e2>", "."], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1430595", "name": "C1430595#ent", "pos": [16, 17]}}
{"token": ["We", "have", "isolated", "a", "cDNA", "encoding", "a", "novel", "human", "intracytoplasmic", "tyrosine", "kinase", "termed", "C1335273#ent", "<e1>", "(", "for", "a", "related", "C1430595#ent", "<e2>", "."], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1430595", "name": "C1430595#ent", "pos": [19, 20]}}
{"token": ["Oxidation", "of", "choline", "was", "enhanced", "at", "2.0", "M", "C3811061#ent", "<e1>", "in", "the", "presence", "or", "absence", "of", "externally", "provided", "C0005304#ent", "<e2>", "."], "h": {"id": "C3811061", "name": "C3811061#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005304", "name": "C0005304#ent", "pos": [18, 19]}}
{"token": ["C0006849#ent", "<e1>", "present", "as", "pseudomembranous", "candidiasis", "C0155964#ent", "<e2>", ",", "or", "perl\u00e8che", "(", "angular", "cheilitis", "."], "h": {"id": "C0006849", "name": "C0006849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0155964", "name": "C0155964#ent", "pos": [6, 7]}}
{"token": ["The", "usual", "therapeutic", "doses", "the", "treatment", "of", "both", "C0002962#ent", "<e1>", "cardiac", "arrhythmia", "widely", "among", "C0304516#ent", "<e2>", "with", "a", "maximum", "of", "about", "a", "200-fold", "difference", ",", "despite", "subjects", "'", "same", "clinical", "improvement", "the", "varying", "doses", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [14, 15]}}
{"token": ["Labetalol", "(", "Trandate", ";", "Allen", "&", "Hanbury", ")", "was", "administered", "to", "17", "hypertensive", "patients", "with", "C0002962#ent", "<e1>", "which", "had", "persisted", "despite", "blood", "pressure", "control", "treatment", "including", "C0304516#ent", "<e2>"], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [26, 27]}}
{"token": ["C0041296#ent", "<e1>", "was", "treated", "with", "rifampin", ",", "C0022209#ent", "<e2>", "and", "pyrazinamide", "in", "60", "patients", ",", "reinforced", "treatment", "in", "14", "and", "alternative", "treatment", "in", "the", "other", "13", "patients", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0022209", "name": "C0022209#ent", "pos": [7, 8]}}
{"token": ["No", "clear", "improvement", "was", "observed", "after", "4", "weeks", "of", "first-line", "C0041296#ent", "<e1>", "treatment", "(", "10", "mg/kg", "rifampin", ",", "15", "mg/kg", "C0022209#ent", "<e2>", ",", "30", "mg/kg", "ethambutol", ",", "30", "mg/kg", "pyrazinamide", ")", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [10, 11]}, "relation": "may_be_prevented_by", "t": {"id": "C0022209", "name": "C0022209#ent", "pos": [20, 21]}}
{"token": ["Treatment", "of", "C0041296#ent", "<e1>", "relies", "mainly", "on", "the", "use", "of", "C0022209#ent", "<e2>", ",", "and", "efforts", "continue", "to", "improve", "patient", "compliance", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [2, 3]}, "relation": "may_be_prevented_by", "t": {"id": "C0022209", "name": "C0022209#ent", "pos": [10, 11]}}
{"token": ["Interestingly", ",", "the", "expression", "of", "HIF2", "alpha", "was", "dependent", "on", "C0812230#ent", "<e1>", ",", "whereas", "that", "of", "C1333897#ent", "<e2>", "dependent", "on", "Akt3", "."], "h": {"id": "C0812230", "name": "C0812230#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [16, 17]}}
{"token": ["We", "examined", "allelic", "polymorphisms", "of", "the", "serotonin", "transporter", "5-HTT", ")", "C0079429#ent", "<e1>", "and", "antidepressant", "response", "6", "weeks", "'", "treatment", "with", "the", "selective", "C0162758#ent", "<e2>", "SSRI", ")", "drugs", "fluoxetine", "paroxetine", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [22, 23]}}
{"token": ["However", ",", "C1412727#ent", "<e1>", "most", "highly", "expressed", "at", "the", "C1280469#ent", "<e2>", "fiber", "projections", "in", "CA3", "."], "h": {"id": "C1412727", "name": "C1412727#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1280469", "name": "C1280469#ent", "pos": [9, 10]}}
{"token": ["Most", "cases", "of", "C0025289#ent", "<e1>", "due", "to", "C0018482#ent", "<e2>", "occurred", "in", "children", "who", "had", "not", "been", "immunized", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0018482", "name": "C0018482#ent", "pos": [7, 8]}}
{"token": ["A", "molecular", "genetic", "approach", "has", "been", "used", "to", "test", "the", "proposition", "that", "the", "central", "hydrophobic", "domain", "C1669085#ent", "<e1>", "represents", "a", "C0021699#ent", "<e2>", "contact", "with", "the", "lipid", "bilayer"], "h": {"id": "C1669085", "name": "C1669085#ent", "pos": [16, 17]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [20, 21]}}
{"token": ["We", "describe", "a", "patient", "with", "an", "episode", "of", "severe", "C0034734#ent", "<e1>", "phenomenon", "and", "early", "or", "C0011644#ent", "<e2>", "presented", "with", "a", "transient", "elevation", "of", "her", "serum", "creatinine", "resolved", "spontaneously", "after", "2", "days", "."], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0011644", "name": "C0011644#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "2", "patients", "with", "C0034734#ent", "<e1>", "phenomenon", "who", "developed", "severe", "C0011644#ent", "<e2>", "changes", "after", "immobilization", "."], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0011644", "name": "C0011644#ent", "pos": [11, 12]}}
{"token": ["C0149937#ent", "<e1>", "renal", "failure", "this", "extent", "have", "not", "been", "previously", "reported", "with", "C0079083#ent", "<e2>"], "h": {"id": "C0149937", "name": "C0149937#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [12, 13]}}
{"token": ["C1413098#ent", "<e1>", "CaMKII", ")", "is", "concentrated", "in", "the", "postsynaptic", "density", "C1418984#ent", "<e2>", ")", "and", "plays", "an", "important", "role", "in", "the", "induction", "of", "long-term", "potentiation", "(", "LTP", ")", "."], "h": {"id": "C1413098", "name": "C1413098#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418984", "name": "C1418984#ent", "pos": [10, 11]}}
{"token": ["The", "results", "further", "suggest", "that", "the", "N-methyl-d-aspartate", "receptors", "the", "alpha-subunits", "of", "C1413098#ent", "<e1>", "likely", "to", "reside", "on", "the", "surface", "of", "the", "C1418984#ent", "<e2>", "although", "with", "unique", "local", "protein", "organizations"], "h": {"id": "C1413098", "name": "C1413098#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418984", "name": "C1418984#ent", "pos": [21, 22]}}
{"token": ["DEANO", "similarly", "reduced", "the", "extent", "of", "C1335809#ent", "<e1>", "expression", "in", "C0342788#ent", "<e2>", "platelets", "."], "h": {"id": "C1335809", "name": "C1335809#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0342788", "name": "C0342788#ent", "pos": [10, 11]}}
{"token": ["The", "other", "was", "capable", "of", "cleaving", "the", "C0752243#ent", "<e1>", "N-carbobenzoxy-L-alanyl-L-alanyl-L-leucine-p-nitroanilide", "and", "resembled", "the", "intracellular", "C0036734#ent", "<e2>", "Bacillus", "spp"], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "C1414326#ent", "<e1>", "immunoreactivity", "is", "colocalized", "with", "increased", "C1420276#ent", "<e2>", "immunoreactivity", "in", "dopaminergic", "neurons"], "h": {"id": "C1414326", "name": "C1414326#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", "we", "examined", "the", "effect", "of", "C0017696#ent", "<e1>", "on", "activation", "of", "the", "transcription", "factors", "C1333571#ent", "<e2>", "AP-1", ")", "and", "specificity", "protein-1", "Sp1", ")", "in", "normal", "human", "dermal", "fibroblasts", "."], "h": {"id": "C0017696", "name": "C0017696#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [16, 17]}}
{"token": ["The", "results", "indicate", "that", "C0008783#ent", "<e1>", "heals", "nearly", "90", "%", "of", "C0038358#ent", "<e2>", "eight", "weeks", "and", "that", "subsequent", "low", "dose", "maintenance", "treatment", "at", "night", "offers", "a", "considerable", "benefit", "over", "placebo", "therapy"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [11, 12]}}
{"token": ["The", "efficacy", "of", "misoprostol", "(", "a", "synthetic", "analogue", "prostaglandin", "E1", "and", "C0008783#ent", "<e1>", "in", "the", "treatment", "of", "C0038358#ent", "<e2>", "evaluated", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [11, 12]}, "relation": "may_prevent", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [17, 18]}}
{"token": ["There", "was", "no", "significant", "difference", "between", "C0008783#ent", "<e1>", "and", "De-Nol", "in", "the", "initial", "healing", "of", "C0038358#ent", "<e2>"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [6, 7]}, "relation": "may_prevent", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [15, 16]}}
{"token": ["Toxicity", "included", "severe", "nausea", "and", "vomiting", "(", "managed", "with", "C0003297#ent", "<e1>", "and", "intravenous", "hydration", "and", "manifestations", "of", "C0151773#ent", "<e2>"], "h": {"id": "C0003297", "name": "C0003297#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151773", "name": "C0151773#ent", "pos": [17, 18]}}
{"token": ["Indeed", ",", "the", "risks", "for", "coronary", "artery", "disease", "C0038454#ent", "<e1>", "greater", "with", "obesity", "combined", "with", "C1705694#ent", "<e2>", "compared", "with", "obesity", "alone", "."], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705694", "name": "C1705694#ent", "pos": [15, 16]}}
{"token": ["We", "sought", "to", "identify", "other", "C1416657#ent", "<e1>", "target", "genes", "and", "determine", "the", "C0008546#ent", "<e2>", "these", "genes", "in", "the", "presence", "and", "absence", "of", "C1416657#ent", "<e1>", "."], "h": {"id": "C1416657", "name": "C1416657#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [12, 13]}}
{"token": ["This", "potentiation", ",", "induced", "by", "millimolar", "concentrations", "of", "C1333909#ent", "<e1>", "+", ",", "is", "not", "mimicked", "by", "Ca2", "+", "and", "C3539699#ent", "<e2>", "+", "and", "is", "voltage", "independent"], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [19, 20]}}
{"token": ["Isoprene-induced", "HG", "neoplasms", "with", "K-ras", "or", "C1705572#ent", "<e1>", "mutations", "had", "an", "elevated", "proliferating", "cell", "nuclear", "antigen", "C1366837#ent", "<e2>", ")", "index", ",", "compared", "to", "spontaneous", "HG", "neoplasms", "ras", "mutations", "."], "h": {"id": "C1705572", "name": "C1705572#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [16, 17]}}
{"token": ["Details", "were", "collected", "of", "the", "total", "number", "of", "patients", "seen", "and", "admitted", "during", "the", "year", ",", "and", "the", "number", "of", "cases", "of", "C0011991#ent", "<e1>", "typhoid", "and", "C0010346#ent", "<e2>"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [22, 23]}, "relation": "manifestation_of", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [26, 27]}}
{"token": ["Moreover", ",", "the", "C1456378#ent", "<e1>", "MAPK", ")", "inhibitor", "SB203580", "and", "overexpressed", "dominant", "negative", "C1366875#ent", "<e2>", "whereas", "dominant", "negative", "p38delta", "increased", "LPS-dependent", "induction", "of", "HO-1", "gene", "expression", "."], "h": {"id": "C1456378", "name": "C1456378#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366875", "name": "C1366875#ent", "pos": [13, 14]}}
{"token": ["In", "separate", "experiments", ",", "rabbits", "were", "given", "C0126174#ent", "<e1>", ",", "enalaprilat", ",", "enalaprilat", "plus", "HOE-140", ",", "C0028066#ent", "<e2>", ",", "-Bay", "K", "4866", ",", "or", "saline", "before", "massively", "activating", "the", "SNS", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [16, 17]}}
{"token": ["To", "compare", "the", "efficacy", "and", "tolerability", "of", "C0126174#ent", "<e1>", ",", "an", "antagonist", "of", "angiotensin", "II", "receptor", "type", "1", "with", "C0028066#ent", "<e2>", "for", "the", "treatment", "of", "primary", "and", "secondary", "Raynaud's", "(", "RP", ")", "in", "a", "pilot", "study"], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [19, 20]}}
{"token": ["Nematode", "nicotinic", "acetylcholine", "receptors", "C1839729#ent", "<e1>", ")", "are", "the", "sites", "of", "action", "for", "the", "C0003158#ent", "<e2>", "levamisole", "."], "h": {"id": "C1839729", "name": "C1839729#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003158", "name": "C0003158#ent", "pos": [14, 15]}}
{"token": ["Overall", ",", "178", "incident", "cases", "of", "benign", "proliferative", "C0006145#ent", "<e1>", "ascertained", "in", "the", "C2936882#ent", "<e2>", "plus", "progestin", "group", "and", "99", "in", "the", "placebo", "group", "."], "h": {"id": "C0006145", "name": "C0006145#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [13, 14]}}
{"token": ["C0027121#ent", "<e1>", "an", "uncommon", "disease", "entity", "occurs", "following", "a", "C0042769#ent", "<e2>", "especially", "with", "influenza", "virus", "that", "has", "been", "experienced", "for", "the", "first", "time", "."], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}}
{"token": ["This", "may", "be", "due", "to", "concomitant", "increases", "in", "in", "vivo", "C0002570#ent", "<e1>", "activity", "or", "other", "less", "specific", "C1442932#ent", "<e2>", "metabolic", "changes", "."], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1442932", "name": "C1442932#ent", "pos": [17, 18]}}
{"token": ["By", "contrast", ",", "when", "C0152177#ent", "<e1>", "neurons", "were", "seeded", "onto", "cryosections", "of", "E10", "C0812267#ent", "<e2>", "-/-", "embryo", "heads", "neurites", "readily", "entered", "mutant", "r3", "mesenchyme", "."], "h": {"id": "C0152177", "name": "C0152177#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812267", "name": "C0812267#ent", "pos": [13, 14]}}
{"token": ["Our", "findings", "indicate", "GDNF", "is", "a", "new", "C1522444#ent", "<e1>", "developing", "peripheral", "neurons", "and", "suggest", "possible", "C2364020#ent", "<e2>", "roles", "for", "GDNF", "in", "the", "developing", "reproductive", "system"], "h": {"id": "C1522444", "name": "C1522444#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2364020", "name": "C2364020#ent", "pos": [15, 16]}}
{"token": ["Hypoxic", "C1428360#ent", "<e1>", "was", "increased", "similarly", "after", "administration", "of", "C0008286#ent", "<e2>", "phenoxybenzamine", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [9, 10]}}
{"token": ["The", "C0869523#ent", "<e1>", "findings", "and", "2", "of", "the", "3", "C1842937#ent", "<e2>", "completely", "resolved", ";", "one", "patient", "has", "persistent", "C1842937#ent", "<e2>", "and", "myopathic", "cardiomegaly", "more", "than", "3", "1/2", "years", "."], "h": {"id": "C0869523", "name": "C0869523#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1842937", "name": "C1842937#ent", "pos": [9, 10]}}
{"token": ["When", "MEnTCD2.5", "animals", "are", "crossed", "to", "a", "second", "line", "ubiquitously", "expressing", "C0086661#ent", "<e1>", ",", "they", "develop", "a", "rapid", "onset", ",", "C0270075#ent", "<e2>", "by", "enlarged", "lymph", "nodes", "of", "nonlymphoid", "cells", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0270075", "name": "C0270075#ent", "pos": [20, 21]}}
{"token": ["C0022642#ent", "<e1>", "treatment", "was", "associated", "with", "reversal", "of", "the", "histopathology", "and", "C0027203#ent", "<e2>", "changes", "in", "every", "case", "."], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["C0031853#ent", "<e1>", "additions", "tended", "to", "increase", "C1835425#ent", "<e2>", "(", "P", "=", "0.07", ")", ",", "regardless", "of", "dietary", "phytate", "concentrations", "."], "h": {"id": "C0031853", "name": "C0031853#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1835425", "name": "C1835425#ent", "pos": [6, 7]}}
{"token": ["C0031853#ent", "<e1>", "also", "increased", "the", "C1835425#ent", "<e2>", ",", "and", "the", "response", "reached", "a", "plateau", "at", "750", "FTU/kg", "diet", "(", "quadratic", "effect", ",", "P", "<", "0.001", ")", "."], "h": {"id": "C0031853", "name": "C0031853#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1835425", "name": "C1835425#ent", "pos": [5, 6]}}
{"token": ["In", "the", "northeast", "of", "Iran", "Golestan", "province", ")", ",", "C0029112#ent", "<e1>", "is", "used", "widely", "for", "symptomatic", "therapy", "of", "routine", "C0679247#ent", "<e2>", "in", "young", "children", "by", "parents", "."], "h": {"id": "C0029112", "name": "C0029112#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0679247", "name": "C0679247#ent", "pos": [19, 20]}}
{"token": ["In", "six", "C0011992#ent", "<e1>", "caused", "by", "food", "allergy", "cows", "'", "C0079840#ent", "<e2>", "allergy", "to", "fresh", "vegetables", ")", "."], "h": {"id": "C0011992", "name": "C0011992#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079840", "name": "C0079840#ent", "pos": [10, 11]}}
{"token": ["Also", "investigated", "was", "the", "modulating", "effect", "of", "this", "agent", "on", "the", "colonic", "mucosal", "tumor", "phospholipase", "A2", "C0089795#ent", "<e1>", "lipoxygenase", ",", "and", "C1565830#ent", "<e2>"], "h": {"id": "C0089795", "name": "C0089795#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [21, 22]}}
{"token": ["The", "effect", "of", "MK-571", "(", "an", "MRP", "inhibitor", ")", "seems", "to", "implicate", "C2828741#ent", "<e1>", "as", "responsible", "for", "apical", "efflux", "trans-piceid", "and", "C1101322#ent", "<e2>", "."], "h": {"id": "C2828741", "name": "C2828741#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1101322", "name": "C1101322#ent", "pos": [21, 22]}}
{"token": ["Fifteen", "of", "them", "had", "C0026847#ent", "<e1>", "by", "genetic", "analysis", "one", "had", "C0152025#ent", "<e2>", "diagnosed", "by", "nerve", "biopsy"], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0152025", "name": "C0152025#ent", "pos": [11, 12]}}
{"token": ["The", "first", "promising", "data", "were", "published", "on", "C0005686#ent", "<e1>", "especially", "with", "regard", "to", "C4055377#ent", "<e2>", "detrusor", "hyperreflexia"], "h": {"id": "C0005686", "name": "C0005686#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C4055377", "name": "C4055377#ent", "pos": [13, 14]}}
{"token": ["The", "expression", "of", "alpha", "6", "beta", "4", "investigated", "in", "several", "autoimmune", "blistering", "skin", "diseases", "bullous", "pemphigoid", "BP", ")", ",", "epidermolysis", "bullosa", "acquisita", "EBA", ")", ",", "C0024141#ent", "<e1>", "BSLE", ")", ",", "and", "C0341009#ent", "<e2>", "PV", ")", "by", "an", "indirect", "immunofluorescence", "technique"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0341009", "name": "C0341009#ent", "pos": [31, 32]}}
{"token": ["However", ",", "sensitization", "of", "cells", "to", "Fas-mediated", "apoptosis", "by", "C0040495#ent", "<e1>", "or", "other", "C0035064#ent", "<e2>", "(", "cycloheximide", ",", "protein", "kinase", "C", "inhibitors", "causes", "less", "Fas", "aggregation", "during", "the", "apoptotic", "process", "with", "that", "in", "nonsensitized", "cells", "."], "h": {"id": "C0040495", "name": "C0040495#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}}
{"token": ["We", "present", "evidence", "that", "FISH", "and", "C0535503#ent", "<e1>", "mediate", "the", "neurotoxic", "effect", "C1705543#ent", "<e2>", "."], "h": {"id": "C0535503", "name": "C0535503#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [12, 13]}}
{"token": ["The", "results", "indicate", "that", "age-related", "decreases", "of", "C0025250#ent", "<e1>", "could", "lead", "to", "increased", "brain", "concentrations", "of", "C1705543#ent", "<e2>", ",", "plaque", "formation", ",", "and", "AD", "."], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [16, 17]}}
{"token": ["C0025250#ent", "<e1>", "(", "NEP", ")", "appears", "to", "be", "the", "major", "C1705543#ent", "<e2>", "degrading", "enzyme", "in", "vivo", "reduced", "mRNA", "levels", "of", "NEP", "correlates", "with", "increased", "plaque", "density", "."], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [10, 11]}}
{"token": ["The", "brain", "has", "an", "endogenous", "mechanism", "of", "C1705543#ent", "<e1>", "removal", "via", "proteolytic", "degradation", "the", "zinc", "metalloproteinase", "neprilysin", "(", "C0025250#ent", "<e2>", ")", "is", "a", "critical", "regulator", "of", "C1705543#ent", "<e1>", "concentration", "."], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [7, 8]}}
{"token": ["DDB", "forms", "a", "complex", "with", "C1332812#ent", "<e1>", "Cul4A", ")", ",", "which", "is", "now", "known", "to", "ubiquitylate", "C1413942#ent", "<e2>", ",", "XPC", ",", "and", "histone", "H2A"], "h": {"id": "C1332812", "name": "C1332812#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413942", "name": "C1413942#ent", "pos": [16, 17]}}
{"token": ["DDB", "forms", "a", "complex", "with", "cullin", "4A", "C1332812#ent", "<e1>", ")", ",", "which", "is", "now", "known", "to", "ubiquitylate", "C1413942#ent", "<e2>", ",", "XPC", ",", "and", "histone", "H2A"], "h": {"id": "C1332812", "name": "C1332812#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413942", "name": "C1413942#ent", "pos": [17, 18]}}
{"token": ["However", ",", "as", "biochemical", "analysis", "pure", "Cul4A-containing", "E3", "is", "missing", ",", "it", "is", "still", "unknown", "whether", "the", "C1332812#ent", "<e1>", "complex", "directly", "ubiquitylates", "C1413942#ent", "<e2>", "or", "not", "."], "h": {"id": "C1332812", "name": "C1332812#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413942", "name": "C1413942#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "oral", "consumption", "C4049720#ent", "<e1>", "from", "RKB", "led", "to", "small", "intestinal", "C0521483#ent", "<e2>", "rats", "."], "h": {"id": "C4049720", "name": "C4049720#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0521483", "name": "C0521483#ent", "pos": [12, 13]}}
{"token": ["We", "speculate", "that", "a", "combinatorial", "role", "of", "PU.1", "and", "C/EBP-beta", "mediates", "the", "robust", "production", "of", "C1565860#ent", "<e1>", "products", "by", "macrophages", "which", "occurs", "in", "Gram-negative", "C0684256#ent", "<e2>"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0684256", "name": "C0684256#ent", "pos": [24, 25]}}
{"token": ["Endemic", "typhus", "C0087031#ent", "<e1>", "is", "very", "closely", "related", "to", "C0041472#ent", "<e2>", "the", "Weil-Felix", "reaction", "is", "positive", ",", "typhus-like", "vascular", "lesions", "are", "present", ",", "and", "there", "is", "cross-immunity", "with", "typhus", "."], "h": {"id": "C0087031", "name": "C0087031#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041472", "name": "C0041472#ent", "pos": [9, 10]}}
{"token": ["In", "rats", "injected", "peripherally", "with", "hCG", ",", "intratesticular", "administration", "the", "C0085387#ent", "<e1>", "indomethacin", ",", "decreased", "C0058310#ent", "<e2>", "levels", "in", "IF", "after", "2", "and", "4", "h", "but", "not", "at", "later", "times", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [15, 16]}}
{"token": ["The", "C0085387#ent", "<e1>", "ibuprofen", "eliminated", "C0058310#ent", "<e2>", "production", ",", "while", "the", "lipoxygenase", "inhibitors", "baicalein", "NDGA", "reduced", "C0058310#ent", "<e2>", "accumulation", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [5, 6]}}
{"token": ["We", "have", "found", "that", "C1539124#ent", "<e1>", "and", "Brf1", "also", "show", "genomic", "losses", "of", "one", "C1706112#ent", "<e2>", "in", "different", "tumors", "."], "h": {"id": "C1539124", "name": "C1539124#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [14, 15]}}
{"token": ["We", "recently", "cloned", "two", "new", "human", "C1333949#ent", "<e1>", "RECQL4", "at", "8q24.3", "and", "C1335670#ent", "<e2>", "at", "17q25", ",", "which", "encode", "members", "of", "the", "RecQ", "helicase", "family"], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1335670", "name": "C1335670#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "C1706445#ent", "<e1>", "DNA-binding", "activity", "to", "be", "regulated", "in", "a", "G2-specific", "fashion", ",", "supporting", "the", "idea", "that", "C1706445#ent", "<e1>", "may", "play", "some", "role", "in", "C1332695#ent", "<e1>"], "h": {"id": "C1706445", "name": "C1706445#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332695", "name": "C1332695#ent", "pos": [25, 26]}}
{"token": ["The", "two", "proteins", "have", "similar", "primary", "structure", "show", "striking", "C2917660#ent", "<e1>", "identity", "with", "aldehyde", "oxidase", "C0043316#ent", "<e2>", "two", "other", "molybdo-flavoenzymes", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0043316", "name": "C0043316#ent", "pos": [15, 16]}}
{"token": ["Tyrosine", "phosphatases", "PTPases", ")", "dephosphorylate", "phosphotyrosines", "while", "C1956000#ent", "<e1>", "DSPases", ")", "dephosphorylate", "contiguous", "and", "semicontiguous", "phosphothreonine", "phosphotyrosine", "on", "cyclin", "dependent", "kinases", "C0752312#ent", "<e2>"], "h": {"id": "C1956000", "name": "C1956000#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [21, 22]}}
{"token": ["The", "copresence", "of", "NADH", "and", "pyruvate", "largely", "protected", "the", "C0027203#ent", "<e1>", "against", "the", "inactivation", "by", "C1705623#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705623", "name": "C1705623#ent", "pos": [15, 16]}}
{"token": ["The", "apparent", "stoichiometry", "of", "the", "reaction", "was", "one", "to", "one", "as", "the", "incorporation", "of", "0.65", "mole", "PLP/mole", "of", "C0027203#ent", "<e1>", "led", "to", "70", "%", "inactivation", "at", "saturating", "C1705623#ent", "<e2>", "concentration", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705623", "name": "C1705623#ent", "pos": [27, 28]}}
{"token": ["A", "new", "C0013227#ent", "<e1>", ",", "Y-27632", ",", "specifically", "inhibits", "C0389995#ent", "<e2>", "and", "hence", "decreases", "the", "phosphorylation", "of", "myosin", "light", "chain", "thus", "reducing", "contraction", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0389995", "name": "C0389995#ent", "pos": [9, 10]}}
{"token": ["We", "administered", "a", "questionnaire", "to", "assess", "maintenance", "of", "patients", "'", "blindness", "at", "the", "end", "of", "a", "double-blind", "clinical", "trial", "of", "Osmotic", "Release", "C0031495#ent", "<e1>", "PPA", ")", "vs.", "placebo", "in", "C0028754#ent", "<e2>"], "h": {"id": "C0031495", "name": "C0031495#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [29, 30]}}
{"token": ["We", "administered", "a", "questionnaire", "to", "assess", "maintenance", "of", "patients", "'", "blindness", "at", "the", "end", "of", "a", "double-blind", "clinical", "trial", "of", "Osmotic", "Release", "Oral", "System", "phenylpropanolamine", "C0031495#ent", "<e1>", ")", "vs.", "placebo", "in", "C0028754#ent", "<e2>"], "h": {"id": "C0031495", "name": "C0031495#ent", "pos": [25, 26]}, "relation": "may_treat", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [31, 32]}}
{"token": ["Molindone", "may", "represent", "an", "alternative", "neuroleptic", "to", "consider", "in", "patients", "with", "a", "history", "of", "NMS", ",", "although", "all", "C0040615#ent", "<e1>", "including", "clozapine", "and", "C0026388#ent", "<e2>", "may", "potentially", "precipitate", "this", "syndrome", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [18, 19]}, "relation": "therapeutic_class_of", "t": {"id": "C0026388", "name": "C0026388#ent", "pos": [23, 24]}}
{"token": ["In", "fact", ",", "NF-kappaB", "is", "C0907533#ent", "<e1>", "activated", "in", "some", "rheumatic", "conditions", "such", "as", "C0038013#ent", "<e2>", "RA", ")", "and", "systemic", "lupus", "erythematosus", "SLE", ")", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [14, 15]}}
{"token": ["These", "results", "confirm", "that", "blockade", "of", "the", "alpha", "1-adrenoceptor", "during", "C0151744#ent", "<e1>", "reperfusion", "decreases", "the", "incidence", "of", "arrhythmias", "and", "C2712370#ent", "<e2>", "cellular", "electrophysiology", "ischaemia", "and", "reperfusion", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [19, 20]}}
{"token": ["In", "the", "latter", ",", "C0069562#ent", "<e1>", "increased", "the", "antisense-transcript", "corresponding", "to", "the", "3'-UTR", "of", "C1417760#ent", "<e2>", "mRNA", ",", "which", "stabilizes", "C1417760#ent", "<e2>", "mRNA", "by", "interacting", "with", "the", "3'-UTR", "and", "RNA-binding", "proteins"], "h": {"id": "C0069562", "name": "C0069562#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [14, 15]}}
{"token": ["For", "product", "formulations", "Pearson's", "correlation", "coefficients", "comparisons", "of", "Draize", "C1706475#ent", "<e1>", "to", "TEP", "and", "C1415273#ent", "<e2>", "data", "were", "0.86", "and", "0.80", ",", "respectively", "."], "h": {"id": "C1706475", "name": "C1706475#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415273", "name": "C1415273#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "the", "effects", "of", "protykin", ",", "a", "standardized", "extract", "C1101322#ent", "<e1>", "from", "Polygonum", "cuspidatum", "on", "C0007209#ent", "<e2>", "the", "incidence", "of", "reperfusion-induced", "arrhythmias", "and", "free", "radical", "production", "isolated", "ischemic/reperfused", "rat", "hearts", "."], "h": {"id": "C1101322", "name": "C1101322#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [16, 17]}}
{"token": ["It", "has", "been", "postulated", "that", "C1101322#ent", "<e1>", "may", "act", "as", "an", "antioxidant", ",", "C0007209#ent", "<e2>", ",", "neuroprotective", "and", "cancer", "chemopreventive", "agent"], "h": {"id": "C1101322", "name": "C1101322#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [13, 14]}}
{"token": ["Neuraminidase", "(", "NA", ")", "is", "a", "critical", "C0014442#ent", "<e1>", "of", "the", "influenza", "virus", "many", "inhibitors", "targeting", "this", "C0014442#ent", "<e1>", "are", "quite", "efficient", "C1579422#ent", "<e1>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1579422", "name": "C1579422#ent", "pos": [22, 23]}}
{"token": ["Expression", "of", "most", "known", "flowering-time", "genes", "did", "not", "depend", "on", "MSI1", ",", "but", "the", "induction", "of", "C3540812#ent", "<e1>", "was", "delayed", "in", "partially", "complemented", "C2697966#ent", "<e2>", "mutants", "."], "h": {"id": "C3540812", "name": "C3540812#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2697966", "name": "C2697966#ent", "pos": [23, 24]}}
{"token": ["To", "determine", "whether", "acute", "C0699744#ent", "<e1>", "media", "can", "be", "distinguished", "from", "an", "uncomplicated", "C0581381#ent", "<e2>", "the", "symptoms", "of", "the", "children", "."], "h": {"id": "C0699744", "name": "C0699744#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [13, 14]}}
{"token": ["It", "is", "extremely", "important", "to", "consider", "Fusobacterium", "necrophorum", "a", "cause", "of", "meningitis", "in", "children", "after", "C0699744#ent", "<e1>", "or", "other", "C0581381#ent", "<e2>", "because", "of", "its", "increasing", "incidence", "."], "h": {"id": "C0699744", "name": "C0699744#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [19, 20]}}
{"token": ["C1840402#ent", "<e1>", "is", "the", "main", "feature", "of", "multiple", "endocrine", "neoplasia", "type", "1", "C0694884#ent", "<e2>", ")", ",", "making", "the", "recently", "cloned", "MEN1", "gene", "prime", "candidate", "gene", "in", "this", "family", "."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0694884", "name": "C0694884#ent", "pos": [12, 13]}}
{"token": ["Systolic", "blood", "pressure", "response", "intravenous", "C0026454#ent", "<e1>", "and", "norepinephrine", "was", "unchanged", "after", "2", "mg", "C0109751#ent", "<e2>", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0109751", "name": "C0109751#ent", "pos": [14, 15]}}
{"token": ["We", "have", "assessed", "the", "value", "of", "parenteral", "vitamin", "D", "oral", "hydroxyapatite", "HA", ")", ",", "and", "C0006699#ent", "<e1>", "CG", ")", "in", "the", "treatment", "of", "cortical", "bone", "thinning", "C0008312#ent", "<e2>"], "h": {"id": "C0006699", "name": "C0006699#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [26, 27]}}
{"token": ["The", "preparation", "contained", "a", "minimum", "of", "three", "C3540772#ent", "<e1>", "capable", "of", "splitting", "alpha-D-mannosidic", "bonds", ":", "alpha-mannosidase", ",", "C0053413#ent", "<e2>", ",", "and", "endomannanase", ",", "which", "were", "separated", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0053413", "name": "C0053413#ent", "pos": [17, 18]}}
{"token": ["Both", "C3540772#ent", "<e1>", "are", "constitutive", ";", "C0053413#ent", "<e2>", "is", "extracellular", ",", "alpha-mannosidase", "was", "found", "in", "both", "mycelium", "and", "cultivation", "medium"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0053413", "name": "C0053413#ent", "pos": [6, 7]}}
{"token": ["Autosomal-dominant", "juvenile", "hyperuricemia", ",", "C0003868#ent", "<e1>", "medullary", "cysts", "and", "progressive", "renal", "insufficiency", "features", "associated", "with", "C2751310#ent", "<e2>", "FJHN", ")", ",", "medullary", "cystic", "kidney", "disease", "type", "1", "MCKD1", ")", "and", "type", "2", "MCKD2", ")", "."], "h": {"id": "C0003868", "name": "C0003868#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2751310", "name": "C2751310#ent", "pos": [15, 16]}}
{"token": ["Unoprostone", "0.12", "%", "appears", "to", "have", "similar", "efficacy", "to", "C0087093#ent", "<e1>", "0.5", "%", "in", "patients", "with", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [16, 17]}}
{"token": ["C0215825#ent", "<e1>", "is", "a", "novel", "C0030956#ent", "<e2>", "that", "exerts", "a", "potent", ",", "dose-dependent", "and", "long-lasting", "hypotensive", "effect", "."], "h": {"id": "C0215825", "name": "C0215825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}}
{"token": ["Inhibition", "of", "C1565919#ent", "<e1>", "activity", "with", "G\u00f6-6976", ",", "or", "C0001486#ent", "<e2>", "overexpression", "of", "kinase-negative", "C1565919#ent", "<e1>", ",", "was", "ineffective", "."], "h": {"id": "C1565919", "name": "C1565919#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [9, 10]}}
{"token": ["C0238377#ent", "<e1>", "due", "to", "intravenous", "injection", "of", "C0035064#ent", "<e2>", "cause", "severe", "pulmonary", "disease", "progressive", "dyspnea", "even", "when", "drug", "use", "discontinued", "."], "h": {"id": "C0238377", "name": "C0238377#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [7, 8]}}
{"token": ["In", "a", "randomized", "double-blind", "parallel", "group", "study", "the", "effects", "of", "C0071132#ent", "<e1>", "on", "serum", "electrolytes", "on", "symptoms", "of", "C0018802#ent", "<e2>", "compared", "with", "those", "of", "the", "combination", "C0071132#ent", "<e1>", "plus", "triamterene", "in", "out-patients", "with", "mild", "to", "severe", "C0018802#ent", "<e2>"], "h": {"id": "C0071132", "name": "C0071132#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [18, 19]}}
{"token": ["The", "haemodynamic", "effect", "of", "a", "single", "12", "mg", "intravenous", "dose", "C0071132#ent", "<e1>", "was", "assessed", "in", "11", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0071132", "name": "C0071132#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [18, 19]}}
{"token": ["A", "double-blind", "parallel", "group", "study", "carried", "out", "to", "compare", "the", "effects", "of", "C0071132#ent", "<e1>", "on", "daily", "glucose", "profiles", ",", "symptoms", "of", "C0018802#ent", "<e2>", "serum", "electrolytes", "those", "of", "furosemide", "in", "24", "diabetic", "in-patients", "suffering", "from", "C0018802#ent", "<e2>"], "h": {"id": "C0071132", "name": "C0071132#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["To", "evaluate", "the", "acute", "and", "chronic", "effects", "diuretic", "monotherapy", "with", "3", "mg", "C0071132#ent", "<e1>", "bid", ",", "46", "patients", "(", "pts", ")", "with", "C0018802#ent", "<e2>", "NYHA", "II-III", "secondary", "to", "coronary", "artery", "disease", "studied", "."], "h": {"id": "C0071132", "name": "C0071132#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [22, 23]}}
{"token": ["Morphologically", "three", "types", "of", "C0029896#ent", "<e1>", "can", "be", "classified", "in", "the", "salivary", "glands", "C0037023#ent", "<e2>", ",", "sialadenitis", "and", "tumours.(ABSTRACT", "TRUNCATED", "AT", "400", "WORDS", ")"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037023", "name": "C0037023#ent", "pos": [13, 14]}}
{"token": ["In", "the", "oral", "and", "maxillo-facial", "region", ",", "the", "virus", "causes", "a", "wide", "variety", "of", "C0029896#ent", "<e1>", ",", "mainly", "atypical", "chronic", "ulcerations", "C0037023#ent", "<e2>", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0037023", "name": "C0037023#ent", "pos": [21, 22]}}
{"token": ["In", "a", "series", "of", "chemical", "modifications", "phenylglyoxal", "almost", "completely", "eliminated", "the", "C1456357#ent", "<e1>", "activity", "and", "C0012186#ent", "<e2>", "suppressed", "activity", "by", "more", "than", "70", "%", "."], "h": {"id": "C1456357", "name": "C1456357#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012186", "name": "C0012186#ent", "pos": [15, 16]}}
{"token": ["L-1", ",", "pH", "7.4", ")", "buffer", "showed", "an", "enhancement", "of", "calmodulin", "(", "CaM", ")", "activated", "C0001477#ent", "<e1>", "with", "the", "membrane", "prepared", "in", "C0020924#ent", "<e2>", "10", "mmol", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020924", "name": "C0020924#ent", "pos": [22, 23]}}
{"token": ["C0080298#ent", "<e1>", "is", "a", "proto-oncogene", "involved", "in", "the", "C4255166#ent", "<e2>", "of", "and", "invasion", "by", "many", "cancers", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4255166", "name": "C4255166#ent", "pos": [8, 9]}}
{"token": ["The", "tumors", "were", "examined", "for", "loss", "of", "heterozygosity", "markers", "from", "C0265428#ent", "<e1>", "10", ",", "and", "17p", "and", "for", "amplification", "of", "the", "C0242982#ent", "<e2>"], "h": {"id": "C0265428", "name": "C0265428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242982", "name": "C0242982#ent", "pos": [21, 22]}}
{"token": ["Analysis", "of", "the", "sequences", "revealed", "the", "consensus", "promoter", "sequences", "gram-positive", "bacteria", "C1418887#ent", "<e1>", "and", "P2", "upstream", "of", "the", "hrcA", "and", "C1428391#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1428391", "name": "C1428391#ent", "pos": [20, 21]}}
{"token": ["Spontaneous", "mutations", "of", "hepatitis", "B", "virus", "C0019163#ent", "<e1>", ")", "could", "influence", "the", "severity", "of", "C0023895#ent", "<e2>"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [14, 15]}}
{"token": ["Acute", "and", "chronic", "infection", "hepatitis", "B", "virus", "C0019163#ent", "<e1>", ")", "is", "associated", "with", "increased", "risk", "of", "developing", "C0023895#ent", "<e2>", "cirrhosis", ",", "decompensated", "liver", "disease", "and", "hepatocellular", "carcinoma"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [17, 18]}}
{"token": ["In", "11", "patients", ",", "diagnosis", "of", "active", "C0023281#ent", "<e1>", "established", "by", "microscopic", "examination", "of", "biopsy", "samples", "clinical", "response", "C1096768#ent", "<e2>"], "h": {"id": "C0023281", "name": "C0023281#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1096768", "name": "C1096768#ent", "pos": [18, 19]}}
{"token": ["Serology", "for", "C0023281#ent", "<e1>", "was", "positive", "and", "treatment", "with", "allopurinol", "and", "C1096768#ent", "<e2>", "started", "."], "h": {"id": "C0023281", "name": "C0023281#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1096768", "name": "C1096768#ent", "pos": [11, 12]}}
{"token": ["Hemojuvelin", "is", "a", "member", "of", "the", "C1428631#ent", "<e1>", "RGM", ")", "family", ",", "which", "also", "includes", "the", "C0377148#ent", "<e2>", "BMP", ")", "coreceptors", "RGMA", "and", "DRAGON", "(", "RGMB", ")", "."], "h": {"id": "C1428631", "name": "C1428631#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [16, 17]}}
{"token": ["This", "lack", "of", "clinical", "benefit", "on", "functional", "capacity", "and", "left", "ventricular", "function", "together", "with", "frequent", "adverse", "reactions", "will", "limit", "the", "application", "of", "C0002697#ent", "<e1>", "in", "the", "treatment", "of", "C0018801#ent", "<e2>"], "h": {"id": "C0002697", "name": "C0002697#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [28, 29]}}
{"token": ["In", "a", "prospective", "trial", "the", "immediate", "and", "long-term", "haematological", "effects", "C0002697#ent", "<e1>", "were", "studied", "in", "sixteen", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0002697", "name": "C0002697#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}}
{"token": ["These", "marked", "cardiotonic", "effects", "C0002697#ent", "<e1>", "in", "patients", "already", "taking", "digitalis", "for", "severe", "C0018801#ent", "<e2>", "without", "side", "effects", "arrhythmias", "or", "altered", "arterial", "pressures"], "h": {"id": "C0002697", "name": "C0002697#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [13, 14]}}
{"token": ["The", "injection", "of", "the", "alpha", "1/alpha", "2-adrenoceptor", "antagonist", ",", "phentolamine", ",", "and", "the", "C0001640#ent", "<e1>", "prazosin", ",", "significantly", "decreased", "blood", "neutrophilia", "induced", "by", "C2697656#ent", "<e2>", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [23, 24]}}
{"token": ["C0012010#ent", "<e1>", "is", "such", "a", "drug", "that", "undergoes", "metabolism", "by", "C1142644#ent", "<e2>", "with", "sigmoidal", "dependence", "."], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [10, 11]}}
{"token": ["In", "the", "present", "study", ",", "C0012010#ent", "<e1>", ",", "temazepam", "and", "nordiazepam", "were", "employed", "as", "substrates", "of", "C1142644#ent", "<e2>", "to", "propose", "a", "kinetic", "model"], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [16, 17]}}
{"token": ["Trovafloxacin", "has", "been", "found", "to", "be", "associated", "with", "higher", "incidence", "of", "CNS", "events", "(", "particularly", "C0012833#ent", "<e1>", "and", "dizziness", ")", "than", "the", "other", "3", "C0035064#ent", "<e2>", "."], "h": {"id": "C0012833", "name": "C0012833#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [24, 25]}}
{"token": ["Lysosomal", "processing", "anthrax", "lethal", "toxin", "LTX", ")", "is", "a", "key", "event", "in", "the", "disease", "pathogenesis", "and", "C0991617#ent", "<e1>", "interfering", "with", "this", "process", ",", "like", "C0055461#ent", "<e2>", "(", "CQ", ")", ",", "may", "have", "practical", "applications", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [24, 25]}}
{"token": ["Activity", "was", "seen", "in", "the", "C0024902#ent", "<e1>", "of", "a", "patient", "with", "C0269995#ent", "<e2>", "72", "h", "after", "intravenous", "injection", "of", "Ga-67", "citrate"], "h": {"id": "C0024902", "name": "C0024902#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0269995", "name": "C0269995#ent", "pos": [11, 12]}}
{"token": ["In", "both", "cases", "the", "C0851341#ent", "<e1>", "provoked", "few", "symptoms", "(", "C3714552#ent", "<e2>", ",", "vague", "abdominal", "discomfort", "intermittent", "and", "apparently", "banal", "diarrhoea", "."], "h": {"id": "C0851341", "name": "C0851341#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [10, 11]}}
{"token": ["Of", "760", "consecutive", "cases", "with", "anterior", "acute", "myocardial", "infarction", "C0340293#ent", "<e1>", ")", ",", "55", "developed", "acute", "bundle-branch", "block", "BBB", ")", ",", "C0085615#ent", "<e2>", "or", "high-degree", "atrioventricular", "block", "the", "hyperacute", "ECG", "stage", "of", "C0340293#ent", "<e1>", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085615", "name": "C0085615#ent", "pos": [21, 22]}}
{"token": ["The", "indication", "for", "pacing", "in", "the", "C0340293#ent", "<e1>", "group", "was", "atrioventricular", "(A-V)", "block", "55", "%", ",", "C0085615#ent", "<e2>", "32", "%", "and", "other", "arrhythmias", "in", "13", "%", "of", "the", "cases", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085615", "name": "C0085615#ent", "pos": [16, 17]}}
{"token": ["C3541418#ent", "<e1>", "can", "pair", "with", "yeast", "Hsp70", "C1540056#ent", "<e2>", "to", "facilitate", "protein", "translocation", "protein", "folding"], "h": {"id": "C3541418", "name": "C3541418#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1540056", "name": "C1540056#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "C3541418#ent", "<e1>", "appears", "more", "efficient", "at", "assisting", "C1540056#ent", "<e2>", "in", "folding", "luciferase", "its", "contains", "a", "zinc", "finger-like", "region", "that", "is", "absent", "from", "Sis1", "."], "h": {"id": "C3541418", "name": "C3541418#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1540056", "name": "C1540056#ent", "pos": [9, 10]}}
{"token": ["The", "ADH1", "and", "C1705836#ent", "<e1>", "the", "major", "C0001942#ent", "<e2>", "S.", "cerevisiae"], "h": {"id": "C1705836", "name": "C1705836#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [7, 8]}}
{"token": ["Polymorphism", "at", "the", "C1705836#ent", "<e1>", "and", "ADH3", "loci", "of", "C0001942#ent", "<e2>", "ADH", ")", "has", "been", "shown", "to", "have", "an", "effect", "on", "the", "predisposition", "to", "alcoholism", "in", "Asian", "individuals", "."], "h": {"id": "C1705836", "name": "C1705836#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [9, 10]}}
{"token": ["Class", "II", "alcohol", "dehydrogenase", "C1705836#ent", "<e1>", ")", "represents", "a", "highly", "divergent", "class", "of", "C0001942#ent", "<e2>", "found", "in", "liver", "."], "h": {"id": "C1705836", "name": "C1705836#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [13, 14]}}
{"token": ["OP-Tc", "is", "inhibited", "by", "alkylating", "agents", "by", "serine", "peptidase-specific", "inhibitors", "3,4-dichloroisocoumarin", ",", "C0047895#ent", "<e1>", "and", "diispropylfluoro-phosphate", "and", "by", "other", "peptidase", "inhibitors", "leupeptin", ",", "C0003403#ent", "<e2>", "and", "peptidyl", "chloromethyl", "ketones"], "h": {"id": "C0047895", "name": "C0047895#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003403", "name": "C0003403#ent", "pos": [23, 24]}}
{"token": ["2", "-", "5A", "C0023689#ent", "<e1>", "is", "the", "C0027203#ent", "<e2>", "the", "2", "-", "5A", "system", "an", "important", "mediator", "of", "interferon", "action"], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}}
{"token": ["C0023689#ent", "<e1>", "a", "soluble", "C0027203#ent", "<e2>", "that", "requires", "the", "presence", "of", "ATP", ",", "beta-alanine", ",", "and", "histamine", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}}
{"token": ["These", "observations", "suggest", "that", "the", "amino-terminal", "domain", "PI", "binding", "to", "C1364818#ent", "<e1>", "and", "that", "the", "C1416809#ent", "<e2>", "PDZ", "motifs", "is", "essential", "to", "modulate", "C1364818#ent", "<e1>", "processing", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416809", "name": "C1416809#ent", "pos": [15, 16]}}
{"token": ["C1364818#ent", "<e1>", "is", "a", "type-1", "membrane-spanning", "protein", ",", "and", "its", "C1416809#ent", "<e2>", "binds", "to", "X11beta", ",", "a", "neuronal", "adaptor", "protein"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416809", "name": "C1416809#ent", "pos": [10, 11]}}
{"token": ["Further", ",", "the", "enzyme", "from", "the", "kidney", "of", "C0271801#ent", "<e1>", "animals", "responded", "to", "phenylephrine", "and", "C0282210#ent", "<e2>", "."], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [15, 16]}}
{"token": ["C0271801#ent", "<e1>", "rats", "failed", "to", "augment", "left", "ventricular", "-dP/dt", "response", "to", "C0282210#ent", "<e2>", "challenge", "."], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [11, 12]}}
{"token": ["Cells", "with", "an", "apparently", "functional", "C1333237#ent", "<e1>", "show", "increased", "radiation", "sensitivity", "to", "C2713546#ent", "<e2>", "in", "specific", "kinases", "essential", "for", "repair", "activation", "checkpoint", "control"], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [12, 13]}}
{"token": ["Similar", "\"", "modulation", "pattern", "\"", "in", "corresponding", "CD34(+", ")", "and", "CD34(-", ")", "cell", "fractions", "a", "generalized", "reduction", "C1333237#ent", "<e1>", "capacity", "of", "CD34(+", ")", "cells", ",", "rather", "than", "C2713546#ent", "<e2>", "in", "a", "specific", "pathway", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [27, 28]}}
{"token": ["Results", "showed", "that", "the", "lysostaphin", "gene", "be", "expressed", "stably", "at", "high", "level", "in", "Bacillus", "sphaericus", "the", "C0024370#ent", "<e1>", "activity", "was", "about", "122", "u/ml", "medium", "after", "C0040822#ent", "<e2>"], "h": {"id": "C0024370", "name": "C0024370#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0040822", "name": "C0040822#ent", "pos": [25, 26]}}
{"token": ["This", "experiment", "showed", "that", "centromeric", "and/or", "C0087071#ent", "<e1>", "DNAs", "are", "enriched", "more", "in", "C1706550#ent", "<e2>", "than", "in", "MNCs", "."], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706550", "name": "C1706550#ent", "pos": [13, 14]}}
{"token": ["ASA", "desensitization", "AD", ")", "followed", "by", "an", "C3853627#ent", "<e1>", "maintenance", "program", "(", "C2984597#ent", "<e2>", ")", "therefore", "appeared", "to", "be", "beneficial", "in", "approximately", "50", "%", "of", "AS", "asthmatics", "."], "h": {"id": "C3853627", "name": "C3853627#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2984597", "name": "C2984597#ent", "pos": [12, 13]}}
{"token": ["When", "these", "mice", "were", "reconstituted", "with", "monoclonal", "anti-DNP", "antibodies", "only", "IgE", ",", "but", "not", "IgG1", ",", "restored", "C0032285#ent", "<e1>", "decreased", "the", "conductance", "of", "the", "respiratory", "system", "therefore", ",", "increasing", "C0085129#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085129", "name": "C0085129#ent", "pos": [29, 30]}}
{"token": ["Most", "animal", "models", "too", "little", "attention", "to", "C0032285#ent", "<e1>", "the", "cause", "of", "C0085129#ent", "<e2>", "asthma", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085129", "name": "C0085129#ent", "pos": [12, 13]}}
{"token": ["In", "rodent", "models", "Sephadex", "produces", "C0032285#ent", "<e1>", "may", "be", "associated", "with", "C0085129#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085129", "name": "C0085129#ent", "pos": [11, 12]}}
{"token": ["Local", ",", "intrapulmonary", "blockade", "of", "CD49d", "by", "intranasal", "administration", "CD49d", "mAb", "inhibited", "all", "signs", "of", "C0032285#ent", "<e1>", "IL-4", "and", "IL-5", "release", ",", "and", "C0085129#ent", "<e2>", "to", "methacholine", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085129", "name": "C0085129#ent", "pos": [23, 24]}}
{"token": ["These", "other", "proteins", "include", "C1415760#ent", "<e1>", ",", "p60", ",", "and", "several", "C1414624#ent", "<e2>", "immunophilins", ")", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414624", "name": "C1414624#ent", "pos": [11, 12]}}
{"token": ["The", "inhibition", "of", "catecholamine", "secretion", "by", "C0022180#ent", "<e1>", "was", "not", "overcome", "by", "increasing", "the", "concentration", "of", "C0006945#ent", "<e2>", "."], "h": {"id": "C0022180", "name": "C0022180#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [16, 17]}}
{"token": ["Isometric", "relaxations", "by", "halothane", ",", "C0022180#ent", "<e1>", "and", "desflurane", "bubbled", "on", "human", "bronchial", "rings", "with", "C0006945#ent", "<e2>", "were", "recorded", "and", "compared", "with", "time", "controls"], "h": {"id": "C0022180", "name": "C0022180#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [15, 16]}}
{"token": ["Treatment", "with", "C0043775#ent", "<e1>", "before", "activation", "with", "C1333574#ent", "<e2>", "did", "not", "blunt", "the", "actin", "responses", "despite", "complete", "inhibition", "of", "an", "intracellular", "calcium", "increase"], "h": {"id": "C0043775", "name": "C0043775#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [7, 8]}}
{"token": ["Inhibitors", "of", "T", "cell", ",", "C0010592#ent", "<e1>", "A", "and", "anti-LFA-1", "antibody", ",", "blocked", "the", "induction", "of", "C1706383#ent", "<e2>", "and", "c-ets-1", "mRNAs", "without", "reducing", "the", "levels", "of", "c-myc", "and", "c-ets-2", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [16, 17]}}
{"token": ["C0010592#ent", "<e1>", "FK506", "slightly", "attenuated", "brain", "natriuretic", "peptide", "did", "not", "affect", "C1706383#ent", "<e2>", "or", "atrial", "natriuretic", "peptide", "expression", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", ",", "we", "show", "that", "TRPM6", "expression", "is", "suppressed", "by", "cyclosporin", "A", "C0010592#ent", "<e1>", ")", "via", "a", "down-regulation", "of", "C1706383#ent", "<e2>", "expression", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [21, 22]}}
{"token": ["FK506", "and", "C0010592#ent", "<e1>", "also", "reduced", "expression", "of", "the", "proto-oncogenes", ",", "c-myc", "and", "C1706383#ent", "<e2>", ",", "but", "not", "c-jun", "and", "interleukin-2-receptor-alpha", "(", "IL-2R", "alpha", "gene", "in", "H109", "cells", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [13, 14]}}
{"token": ["Clouston", "syndrome", "hidrotic", "ectodermal", "dysplasia", "is", "an", "C2936739#ent", "<e1>", "ectodermal", "dysplasia", "by", "alopecia", ",", "palmoplantar", "hyperkeratosis", "and", "C0221260#ent", "<e2>"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221260", "name": "C0221260#ent", "pos": [17, 18]}}
{"token": ["C3889457#ent", "<e1>", "is", "the", "ER", "representative", "of", "the", "C3273507#ent", "<e2>", "family", "of", "stress-induced", "proteins"], "h": {"id": "C3889457", "name": "C3889457#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [8, 9]}}
{"token": ["The", "findings", "indicate", "that", "C0055854#ent", "<e1>", "has", "opposite", "effects", "on", "C0027203#ent", "<e2>", "and", "fluid", "secretion", "by", "rat", "and", "rabbit", "pancreas", ",", "which", "are", "not", "due", "to", "circulatory", "effects"], "h": {"id": "C0055854", "name": "C0055854#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["The", "three", "main", "viral", "diseases", "which", "interferon", "alfa-2b", "been", "shown", "to", "have", "activity", "are", "C0524909#ent", "<e1>", "acquired", "immunodeficiency", "syndrome", "and", "human", "C0950124#ent", "<e2>"], "h": {"id": "C0524909", "name": "C0524909#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0950124", "name": "C0950124#ent", "pos": [21, 22]}}
{"token": ["A", "high-affinity", "receptor", "site", "3H-P1075", "previously", "observed", "in", "rat", "aorta", "has", "been", "proposed", "to", "mediate", "the", "vasorelaxation", "effects", "of", "C0287611#ent", "<e1>", "and", "other", "C1955862#ent", "<e2>", "KATP", ")", "openers", "."], "h": {"id": "C0287611", "name": "C0287611#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1955862", "name": "C1955862#ent", "pos": [23, 24]}}
{"token": ["C0287611#ent", "<e1>", "is", "a", "cyanoguanidine", "ATP-sensitive", "potassium", "channel", "opener", "C1955862#ent", "<e2>", ")", "that", "relaxes", "smooth", "muscle", "shortens", "myocardial", "action", "potential", "duration", "(", "APD", ")", "at", "concentrations", "in", "the", "nanomolar", "range", "."], "h": {"id": "C0287611", "name": "C0287611#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1955862", "name": "C1955862#ent", "pos": [9, 10]}}
{"token": ["C0287611#ent", "<e1>", "is", "a", "C1955862#ent", "<e2>", "KATP", ")", "that", "relaxes", "smooth", "muscle", "shortens", "myocardial", "action", "potential", "duration", "(", "APD", ")", "at", "concentrations", "in", "the", "nanomolar", "range", "."], "h": {"id": "C0287611", "name": "C0287611#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1955862", "name": "C1955862#ent", "pos": [4, 5]}}
{"token": ["Here", "we", "describe", "the", "isolation", "of", "the", "mouse", "(", "MFH-1", ")", "and", "human", "(", "FKHL14", ")", "C1414669#ent", "<e1>", "the", "determination", "of", "the", "C0079429#ent", "<e2>", "and", "protein", "structures", "MFH-1", "."], "h": {"id": "C1414669", "name": "C1414669#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [22, 23]}}
{"token": ["With", "this", "instrument", ",", "the", "incision", "becomes", "much", "safer", ",", "the", "C0041044#ent", "<e1>", "of", "the", "trepan", "becomes", "easier", "and", "an", "unintentional", "injury", "C1256254#ent", "<e2>", "and", "lens", "may", "be", "considerably", "avoided", "."], "h": {"id": "C0041044", "name": "C0041044#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1256254", "name": "C1256254#ent", "pos": [22, 23]}}
{"token": ["One", "drug", ",", "suramin", ",", "which", "was", "originally", "developed", "as", "an", "C0301344#ent", "<e1>", "has", "been", "found", "to", "be", "an", "inhibitor", "of", "C0035379#ent", "<e2>"], "h": {"id": "C0301344", "name": "C0301344#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [21, 22]}}
{"token": ["We", "have", "examined", "the", "sensitivity", "of", "various", "cellular", "and", "viral", "DNA", "polymerases", "Suramin", ",", "an", "C0301344#ent", "<e1>", "which", "has", "been", "reported", "to", "exhibit", "C0035379#ent", "<e2>"], "h": {"id": "C0301344", "name": "C0301344#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [23, 24]}}
{"token": ["Seventy", "five", "of", "the", "100", "C1875400#ent", "<e1>", "from", "C1420519#ent", "<e2>", "clinic", "patients", "and", "29", "of", "the", "55", "C1875400#ent", "<e1>", "from", "hospital", "patients", "were", "penicillinase", "producing", "N", "gonorrhoeae", "PPNG", ")", "."], "h": {"id": "C1420519", "name": "C1420519#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [5, 6]}}
{"token": ["Phe", "and", "PDBu", "contraction", "and", "PKC", "activity", "in", "OVX", "females", "or", "castrated", "males", "treated", "with", "C0014914#ent", "<e1>", "plus", "the", "C3850168#ent", "<e2>", "were", "not", "significantly", "different", "from", "untreated", "OVX", "females", "or", "castrated", "males", "."], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3850168", "name": "C3850168#ent", "pos": [19, 20]}}
{"token": ["An", "antagonist", "to", "the", "NMDA", "receptor", "antagonist", "AP5", ",", "abolished", "the", "growth", "promoting", "effect", "of", "17", "C0014914#ent", "<e1>", "whereas", "the", "C3850168#ent", "<e2>", "182,780", "did", "not", "."], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3850168", "name": "C3850168#ent", "pos": [20, 21]}}
{"token": ["This", "study", "examined", "the", "role", "of", "Nrf1", "and", "C1417701#ent", "<e1>", "in", "the", "C1710463#ent", "<e2>", "rat", "GCLC", "."], "h": {"id": "C1417701", "name": "C1417701#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [12, 13]}}
{"token": ["We", "previously", "reported", "that", "on", "T", "cells", "C4283784#ent", "<e1>", "occurs", "almost", "exclusively", "on", "the", "protein", "backbone", "of", "P-selectin", "glycoprotein", "ligand-1", "C4283784#ent", "<e1>", ")", "."], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [7, 8]}}
{"token": ["The", "major", "E-selectin", "ligand", "on", "human", "skin-homing", "T", "cells", "is", "cutaneous", "lymphocyte-associated", "antigen", "C4283784#ent", "<e1>", ")", ",", "a", "specialized", "glycoform", "of", "P-selectin", "glycoprotein", "ligand-1", "C4283784#ent", "<e1>", ")", "defined", "by", "monoclonal", "antibody", "."], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [13, 14]}}
{"token": ["Human", "memory", "T", "cells", "associated", "with", "cutaneous", "inflammatory", "responses", "are", "characterized", "by", "their", "expression", "of", "cutaneous", "lymphocyte-associated", "Ag", "C4283784#ent", "<e1>", ")", ",", "a", "carbohydrate", "determinant", "differentially", "expressed", "on", "P-selectin", "glycoprotein", "ligand-1", "C4283784#ent", "<e1>", ")", "."], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [18, 19]}}
{"token": ["C0005304#ent", "<e1>", "may", "be", "more", "effective", "at", "C2712370#ent", "<e2>", "body", "composition", "barrows", "than", "in", "gilts", "."], "h": {"id": "C0005304", "name": "C0005304#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [7, 8]}}
{"token": ["Treatment", "included", "intermittent", "positive-pressure", "ventilation", "changing", "intravenous", "administration", "fluids", "from", "C0073385#ent", "<e1>", "0.9", "%", "NaCl", "solution", ",", "and", "administration", "of", "C0006699#ent", "<e2>", "glycopyrrolate", ",", "dopamine", ",", "and", "sodium", "bicarbonate"], "h": {"id": "C0073385", "name": "C0073385#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006699", "name": "C0006699#ent", "pos": [20, 21]}}
{"token": ["On", "the", "other", "hand", ",", "both", "the", "human", "adrenal", "cortex", "brain", "show", "evidence", "of", "oxidative", "stress", "e.g.", "hemoxygenase-1", "and", "C1420307#ent", "<e1>", "and", "oxidative", "damage", ",", "particularly", "from", "lipid", "peroxidation", "C0048297#ent", "<e2>", "and", "malondialdehyde", ")", "."], "h": {"id": "C1420307", "name": "C1420307#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0048297", "name": "C0048297#ent", "pos": [29, 30]}}
{"token": ["67Ga", "uptakes", "and", "C1705574#ent", "<e1>", "synthesis", "in", "the", "EST", "were", "inhibited", "by", "pretreatment", "with", "C0002533#ent", "<e2>", "or", "papain", "(", "inhibitors", "of", "fibrosis", ")", "."], "h": {"id": "C1705574", "name": "C1705574#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002533", "name": "C0002533#ent", "pos": [14, 15]}}
{"token": ["Consequently", ",", "we", "examined", "the", "creation", ",", "production", ",", "and", "secretion", "of", "fusion", "constructs", "containing", "C0017768#ent", "<e1>", "and", "either", "C2987364#ent", "<e2>", "TAT", "or", "modified", "TAT", "in", "Sf9", "cells"], "h": {"id": "C0017768", "name": "C0017768#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [19, 20]}}
{"token": ["Unlike", "Apaf-1", ",", "Nod1", "induced", "activation", "of", "nuclear", "factor-kappa-B", "(", "C2986464#ent", "<e1>", ")", "and", "bound", "C1706435#ent", "<e2>", ",", "a", "CARD-containing", "kinase", "also", "induces", "NF-kappaB", "activation"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706435", "name": "C1706435#ent", "pos": [15, 16]}}
{"token": ["Nod1", "mutants", "inhibited", "C2986464#ent", "<e1>", "induced", "by", "C1706435#ent", "<e2>", ",", "but", "not", "that", "resulting", "from", "tumor", "necrosis", "factor-alpha", "stimulation", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706435", "name": "C1706435#ent", "pos": [7, 8]}}
{"token": ["The", "utilization", "of", "D-[5", "-", "3H]glucose", ",", "oxidation", "of", "D-[6", "-", "14C]glucose", "and", "release", "of", "insulin", "evoked", "by", "C0017718#ent", "<e1>", "were", "all", "lower", "in", "C0011860#ent", "<e2>", "patients", "than", "control", "subjects"], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [24, 25]}}
{"token": ["We", "now", "report", "that", "C2985157#ent", "<e1>", "colocalizes", "with", "C1335191#ent", "<e2>", "in", "both", "cytoplasmic", "and", "nuclear", "compartments", "and", "it", "interacts", "directly", "and", "selectively", "with", "C1335191#ent", "<e2>", "via", "the", "leucine", "zipper", "domain", "neural", "cells"], "h": {"id": "C2985157", "name": "C2985157#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335191", "name": "C1335191#ent", "pos": [8, 9]}}
{"token": ["A", "total", "of", "40", "male", "Wistar", "albino", "rats", "were", "divided", "into", "four", "groups", "as", "control", ",", "PQ", ",", "C0011816#ent", "<e1>", "only", ",", "and", "C0011816#ent", "<e1>", "plus", "C3149631#ent", "<e1>", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3149631", "name": "C3149631#ent", "pos": [26, 27]}}
{"token": ["For", "this", "purpose", ",", "combination", "of", "dexamethasone", "(", "C0011816#ent", "<e1>", ")", "and", "melatonin", "(", "C3149631#ent", "<e2>", ")", "was", "compared", "with", "C0011816#ent", "<e1>", "alone", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3149631", "name": "C3149631#ent", "pos": [14, 15]}}
{"token": ["The", "decrease", "in", "synthesis", "observed", "after", "exposure", "to", "actinomycin", "D", "not", "reflected", "by", "any", "significant", "decrease", "in", "the", "activities", "of", "several", "C1333828#ent", "<e1>", "involved", "in", "chondroitin", "sulphate", "synthesis", "galactosyltransferase-I", ",", "galactosyltransferase-II,", "N-acetylgalactosaminyltransferase", "C1259497#ent", "<e2>", ")", "."], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [21, 22]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1259497", "name": "C1259497#ent", "pos": [32, 33]}}
{"token": ["We", "have", "shown", "that", "C0016412#ent", "<e1>", "a", "common", "association", "of", "C0086132#ent", "<e2>", "a", "variety", "of", "settings", "including", "primary", "endogenous", "or", "non-endogenous", "depression", "and", "in", "alcoholic", ",", "lithium-treated", "and", "anorexic", "patients", "."], "h": {"id": "C0016412", "name": "C0016412#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086132", "name": "C0086132#ent", "pos": [10, 11]}}
{"token": ["Therapeutic", "recommendations", "using", "C0033978#ent", "<e1>", "psychotherapy", "for", "treating", "the", "C0859976#ent", "<e2>", "presented", "."], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0859976", "name": "C0859976#ent", "pos": [9, 10]}}
{"token": ["Site-specific", "increases", "in", "fucosylation", "of", "bi-antennary", "glycans", "of", "sites", "2", "4", ",", "and", "of", "tri-antennary", "glycans", "of", "all", "sites", "were", "observed", "in", "C1418724#ent", "<e1>", ",", "compared", "to", "in", "normal", "volunteers", "C0238339#ent", "<e2>"], "h": {"id": "C1418724", "name": "C1418724#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0238339", "name": "C0238339#ent", "pos": [30, 31]}}
{"token": ["C0700349#ent", "<e1>", "PBC", ")", "is", "a", "treatment", "for", "patients", "with", "C0038220#ent", "<e2>", "but", "there", "are", "currently", "few", "guidelines", "for", "choosing", "when", "to", "initiate", "or", "continue", "this", "therapy", "."], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [10, 11]}}
{"token": ["The", "objective", "of", "this", "research", "was", "to", "evaluate", "the", "association", "between", "the", "response", "of", "C0700349#ent", "<e1>", "neurologic", "outcomes", "in", "C0038220#ent", "<e2>"], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [19, 20]}}
{"token": ["C0010980#ent", "<e1>", ",", "associated", "with", "pyrimethamine", "for", "C0040558#ent", "<e2>", "prevention", ",", "and", "atovaquone", "represent", "other", "possible", "alternatives", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0040558", "name": "C0040558#ent", "pos": [7, 8]}}
{"token": ["Here", "we", "cloned", "human", "C1826966#ent", "<e1>", "(", "SUMO-1", "activating", "enzyme", ")", "and", "C1826967#ent", "<e2>", ",", "which", "are", "human", "homologs", "of", "yeast", "Saccharomyces", "cerevisiae", "Aos1", "and", "Uba2", ",", "respectively", "."], "h": {"id": "C1826966", "name": "C1826966#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826967", "name": "C1826967#ent", "pos": [12, 13]}}
{"token": ["The", "DNA-dependent", "protein", "kinase", "catalytic", "subunit", "C1705560#ent", "<e1>", ")", "is", "critical", "for", "C1333237#ent", "<e2>", "the", "nonhomologous", "end", "joining", "pathway"], "h": {"id": "C1705560", "name": "C1705560#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [12, 13]}}
{"token": ["We", "cloned", "a", "cDNA", "coding", "for", "a", "novel", "serine/threonine", "kinase", "C3274855#ent", "<e1>", ",", "a", "protein", "of", "448", "C3539946#ent", "<e2>", "a", "predicted", "molecular", "weight", "51.3", "kDa", "."], "h": {"id": "C3274855", "name": "C3274855#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [17, 18]}}
{"token": ["Antibiotics", "of", "choice", "for", "gangrenous", "lesions", "with", "spreading", "infection", "C0036690#ent", "<e1>", "are", "a", "combination", "of", "gentamycin", ",", "ampicillin", "and", "C0025872#ent", "<e2>", "as", "an", "adjuvant", "to", "surgical", "treatment"], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [19, 20]}}
{"token": ["Delivery", "by", "caesarean", "section", "to", "carry", "a", "risk", "of", "post", "surgical", "anaerobic", "C0036690#ent", "<e1>", "in", "about", "20", "%", "of", "patients", "not", "protected", "with", "C0025872#ent", "<e2>"], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [23, 24]}}
{"token": ["Although", "the", "prenylation", "of", "C1705572#ent", "<e1>", "was", "also", "sensitive", "to", "C0384074#ent", "<e2>", ",", "complete", "inhibition", "of", "C1705572#ent", "<e1>", "processing", "even", "at", "high", "concentrations", "of", "C0384074#ent", "<e2>", "and/or", "GGTI-298", "was", "never", "achieved", "."], "h": {"id": "C0384074", "name": "C0384074#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [4, 5]}}
{"token": ["The", "farnesyltransferase", "(", "FTase", ")", "inhibitor", "C0384074#ent", "<e1>", "is", "highly", "effective", "at", "blocking", "oncogenic", "C1705572#ent", "<e2>", "but", "not", "K-Ras4B", "processing", "and", "signaling", "."], "h": {"id": "C0384074", "name": "C0384074#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [14, 15]}}
{"token": ["Concentrations", "of", "macrophage", "colony-stimulating", "factor", "C1524095#ent", "<e1>", ")", ",", "Interleukin", "(IL)-2", "IL-6", "in", "MLCS", "and", "C0268314#ent", "<e2>", "were", "measured", "."], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268314", "name": "C0268314#ent", "pos": [15, 16]}}
{"token": ["To", "compare", "the", "gastrointestinal", "safety", "ulcerogenic", "potential", ",", "and", "clinical", "efficacy", "5", "years", "of", "C0068334#ent", "<e1>", "and", "naproxen", "therapy", "in", "patients", "with", "rheumatoid", "arthritis", "RA", ")", "or", "C0029408#ent", "<e2>", "(", "OA", ")", "."], "h": {"id": "C0068334", "name": "C0068334#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [27, 28]}}
{"token": ["Results", "indicate", "the", "potential", "for", "a", "decrease", "in", "overall", "medical", "resource", "utilization", "through", "the", "use", "of", "C0068334#ent", "<e1>", "in", "elderly", "patients", "with", "rheumatoid", "and", "C0029408#ent", "<e2>", "."], "h": {"id": "C0068334", "name": "C0068334#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [24, 25]}}
{"token": ["Approximately", "60%-80", "%", "of", "younger", "adults", "AML", "achieve", "complete", "remission", "CR", ")", "with", "the", "C0304497#ent", "<e1>", "cytarabine", "and", "an", "anthracycline", "such", "as", "daunorubicin", "or", "C0020789#ent", "<e2>", "or", "the", "anthracenedione", "mitoxantrone"], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020789", "name": "C0020789#ent", "pos": [24, 25]}}
{"token": ["In", "severely", "affected", "rats", "the", "magnitude", "of", "the", "C1335200#ent", "<e1>", "increased", "along", "with", "C0178664#ent", "<e2>", "but", "disappeared", "later", "from", "areas", "of", "segmental", "and", "global", "glomerular", "obsolescence", "."], "h": {"id": "C1335200", "name": "C1335200#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [13, 14]}}
{"token": ["Modulation", "of", "[3H]flunitrazepam", "binding", "by", "C0038317#ent", "<e1>", ",", "barbiturates", ",", "and", "C0047845#ent", "<e2>", "significantly", "varied", "with", "regions", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0047845", "name": "C0047845#ent", "pos": [11, 12]}}
{"token": ["Addition", "of", "C0028928#ent", "<e1>", "to", "the", "culture", "medium", "not", "alter", "their", "metabolic", "C1539479#ent", "<e2>", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [12, 13]}}
{"token": ["Depletion", "of", "circulating", "C0064833#ent", "<e1>", "PMNs", ")", "abolished", "the", "effect", "of", "PAF", "on", "C1959603#ent", "<e2>", "expression", "and", "enzyme", "activation", "."], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1959603", "name": "C1959603#ent", "pos": [13, 14]}}
{"token": ["Acute", "inflammatory", "responses", "invading", "bacteria", "such", "as", "Staphylococcus", "aureus", "mobilization", "of", "C0064833#ent", "<e1>", "PMN", ")", "and", "extracellular", "group", "C1959603#ent", "<e2>", "gIIA-PLA2", ")", "."], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1959603", "name": "C1959603#ent", "pos": [18, 19]}}
{"token": ["Some", "features", "of", "the", "course", "of", "peptic", "and", "recurrent", "C0149745#ent", "<e1>", "of", "the", "duodenum", "depend", "on", "C0014442#ent", "<e2>", "and", "acid", "producing", "function", "of", "the", "denervated", "stomach", "."], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["55", "%", "of", "the", "children", "were", "completely", "free", "from", "C0149745#ent", "<e1>", "during", "the", "C0014442#ent", "<e2>", "period", "followed", "by", "a", "3-month", "recovery", "period", "compared", "to", "0", "%", "when", "rinsing", "with", "placebo", "."], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["Human", "T", "cell", "lymphotropic", "virus", "type", "I", "HTLV-I", ")", "is", "a", "retrovirus", "that", "has", "been", "linked", "to", "HTLV-I-associated", "myelopathy", "spastic", "paraparesis", "C1710292#ent", "<e1>", ")", ",", "a", "chronic", "or", "C1290884#ent", "<e2>", "some", "resemblance", "to", "multiple", "sclerosis"], "h": {"id": "C1710292", "name": "C1710292#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [28, 29]}}
{"token": ["The", "five", "most", "common", "diagnoses", "were", ":", "common", "C0719425#ent", "<e1>", ",", "chest", "wall", "tenderness", "gastroenteritis", ",", "headache", "and", "C0264222#ent", "<e2>"], "h": {"id": "C0719425", "name": "C0719425#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0264222", "name": "C0264222#ent", "pos": [18, 19]}}
{"token": ["The", "BMP-1/Tolloid", "family", "of", "C2350349#ent", "<e1>", "is", "thereby", "implicated", "in", "the", "processing", "of", "a", "major", "C1415793#ent", "<e2>", "in", "the", "liberation", "of", "an", "anti-angiogenic", "factor"], "h": {"id": "C2350349", "name": "C2350349#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [15, 16]}}
{"token": ["C0961209#ent", "<e1>", "is", "unique", "among", "ophthalmic", "C0003211#ent", "<e2>", "in", "that", "it", "is", "a", "prodrug", "deaminated", "to", "amfenac", ",", "a", "highly", "effective", "non-selective", "cyclooxygenase", "inhibitor"], "h": {"id": "C0961209", "name": "C0961209#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [6, 7]}}
{"token": ["Similar", "to", "melittin", ",", "C0031667#ent", "<e1>", "enhanced", "the", "effect", "of", "C1538681#ent", "<e2>", "release", "in", "a", "dose", "range", "of", "0.1", "-", "100", "units/ml", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1538681", "name": "C1538681#ent", "pos": [10, 11]}}
{"token": ["Selective", "depletion", "of", "C4084905#ent", "<e1>", "dramatically", "increased", "the", "nuclear", "and", "focal", "point", "accumulation", "of", "C0385469#ent", "<e2>", ",", "further", "demonstrating", "a", "role", "for", "C4084905#ent", "<e1>", "in", "C0385469#ent", "<e2>", "translocation", "."], "h": {"id": "C0385469", "name": "C0385469#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [3, 4]}}
{"token": ["Together", ",", "these", "results", "suggest", "that", "C0385469#ent", "<e1>", "is", "a", "C4084905#ent", "<e2>", "substrate", ",", "undergoes", "phosphorylation-dependent", "shuttling", "between", "the", "cell", "nucleus", "cytoplasm", ",", "and", "interacts", "with", "gene-regulatory", "chromatin", "."], "h": {"id": "C0385469", "name": "C0385469#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [10, 11]}}
{"token": ["Questions", "about", "appropriate", "allocation", "of", "simultaneous", "liver", "and", "kidney", "transplants", "C0812303#ent", "<e1>", ")", "are", "being", "asked", "because", "kidney", "dysfunction", "the", "context", "of", "C0085605#ent", "<e2>", "access", "to", "deceased", "donor", "organs"], "h": {"id": "C0812303", "name": "C0812303#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [22, 23]}}
{"token": ["The", "diagnostics", "were", "as", "follows", ":", "pharyngotonsillitis", "(", "1200", ")", ",", "acute", "otitis", "media", "394", ")", ",", "C0149514#ent", "<e1>", "1134", ")", ",", "exacerbation", "of", "C0008677#ent", "<e2>", "436", ")", ",", "and", "community-acquired", "pneumonia", "53", ")", "."], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [24, 25]}}
{"token": ["Bacterial", "and", "viral", "pathogens", "C0149514#ent", "<e1>", "exacerbations", "of", "C0008677#ent", "<e2>", "AECB", ")", "."], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [8, 9]}}
{"token": ["The", "highest", "denitrosation", "activity", "by", "C0796516#ent", "<e1>", "was", "determined", "towards", "BCNU", ",", "followed", "by", "C0687700#ent", "<e2>", "and", "TCNU", "."], "h": {"id": "C0796516", "name": "C0796516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0687700", "name": "C0687700#ent", "pos": [14, 15]}}
{"token": ["Sodium", "and", "C3811086#ent", "<e1>", "the", "macula", "densa", "and", "thick", "ascending", "C0030196#ent", "<e2>", "of", "Henle's", "loop", "importantly", "in", "extracellular", "fluid", "volume", "homeostasis", "urinary", "concentration", "dilution", ",", "control", "of", "glomerular", "filtration", "and", "control", "of", "renal", "hemodynamics"], "h": {"id": "C3811086", "name": "C3811086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [10, 11]}}
{"token": ["The", "present", "studies", "were", "designed", "to", "examine", "whether", "prostaglandin", "E2", "affect", "C3811086#ent", "<e1>", "the", "thick", "ascending", "C0030196#ent", "<e2>", "of", "Henle", "."], "h": {"id": "C3811086", "name": "C3811086#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [16, 17]}}
{"token": ["The", "results", "indicated", "that", "mucosal", "petechiometry", "did", "not", "measure", "the", "haemostatic", "defect", "induced", "by", "aspirin", "and", "that", "C1319853#ent", "<e1>", "alterations", "in", "platelet", "function", "not", "important", "in", "the", "development", "of", "C0031256#ent", "<e2>", "in", "healthy", "subjects"], "h": {"id": "C1319853", "name": "C1319853#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031256", "name": "C0031256#ent", "pos": [29, 30]}}
{"token": ["Besides", "the", "sesquiterpenes", "that", "possess", "chemotaxonomic", "relevance", "and", "mediate", "the", "antiphlogistic", "activity", ",", "the", "plant", "contains", "C0031428#ent", "<e1>", "as", "dicaffeoylquinic", "acids", "flavonoids", "causing", "C0008362#ent", "<e2>", "and", "spasmolytic", "effects"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008362", "name": "C0008362#ent", "pos": [23, 24]}}
{"token": ["We", "report", "a", "62-year-old", "woman", "with", "rheumatoid", "arthritis", "had", "developed", "hepatitis", "and", "C0027947#ent", "<e1>", "simultaneously", "after", "receiving", "137.5", "mg", "of", "C0018034#ent", "<e2>"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018034", "name": "C0018034#ent", "pos": [20, 21]}}
{"token": ["Cold", "pressor", "stress", "a", "greater", "increase", "in", "systolic", "arterial", "pressure", "patients", "with", "C0010068#ent", "<e1>", "than", "in", "subjects", "with", "C1413309#ent", "<e2>", "(", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [18, 19]}}
{"token": ["Tx", "receptor", "density", "was", "significantly", "(", "P<0.05", ")", "increased", "in", "both", "the", "media", "and", "intima", "of", "C0010068#ent", "<e1>", ",", "compared", "with", "C1413309#ent", "<e2>", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [21, 22]}}
{"token": ["This", "study", "investigates", "the", "effect", "of", "cold", "stress", "the", "release", "of", "the", "platelet-specific", "protein", "into", "the", "coronary", "venous", "blood", "12", "subjects", "with", "atherosclerotic", "coronary", "artery", "disease", "C0010068#ent", "<e1>", ")", "and", "7", "subjects", "with", "angiographically", "normal", "coronary", "arteries", "C1413309#ent", "<e2>", ")", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [37, 38]}}
{"token": ["Mutation", "of", "the", "C3537453#ent", "<e1>", "box", "also", "reduced", "C3811130#ent", "<e2>", "promoter", "activity"], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811130", "name": "C3811130#ent", "pos": [8, 9]}}
{"token": ["The", "sequence", "of", "the", "gene", "encoding", "reverse", "gyrase", "an", "archaeon", ",", "Sulfolobus", "acidocaldarius", "suggests", "that", "this", "enzyme", "contains", "both", "a", "C1333949#ent", "<e1>", "and", "a", "C1336767#ent", "<e2>", "Confalonieri", "et", "al.", ",", "Proc", "."], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [24, 25]}}
{"token": ["The", "potential", "importance", "of", "helicase-topoisomerase", "interactions", "been", "highlighted", "by", "recent", "data", "indicating", "that", "the", "protein", "defective", "in", "Bloom's", "syndrome", "a", "C1333949#ent", "<e1>", "with", "a", "yeast", "homologue", "is", "known", "to", "bind", "C1336767#ent", "<e2>", "."], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [30, 31]}}
{"token": ["Reverse", "gyrase", "a", "peculiar", "DNA", "topoisomerase", "specific", "to", "hyperthermophilic", "microorganisms", "which", "contains", "a", "C1333949#ent", "<e1>", "and", "a", "C1336767#ent", "<e2>", "has", "the", "unique", "ability", "to", "introduce", "positive", "supercoiling", "into", "DNA", "molecules"], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [17, 18]}}
{"token": ["Chicks", "fed", "basal", "diets", "5", "%", "ammonium", "chloride", "10", "%", "C2930448#ent", "<e1>", "asparagine", "had", "the", "same", "C0003993#ent", "<e2>", "and", "urine", "pH", "as", "chicks", "fed", "the", "23", "%", "protein", "basal", "control", "diet"], "h": {"id": "C2930448", "name": "C2930448#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003993", "name": "C0003993#ent", "pos": [16, 17]}}
{"token": ["The", "addition", "of", "C2930448#ent", "<e1>", "the", "44.6", "%", "PE", "amino", "acid", "diet", "decreased", "the", "C0003993#ent", "<e2>", "activity", "equivalent", "to", "C0003993#ent", "<e2>", "activity", "of", "chicks", "fed", "the", "14.8", "%", "PE", "diet"], "h": {"id": "C2930448", "name": "C2930448#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003993", "name": "C0003993#ent", "pos": [14, 15]}}
{"token": ["This", "C1412215#ent", "<e1>", "mutation", "could", "disturb", "RNA", "editing", "Q/R", "sites", "of", "C1415287#ent", "<e2>", "the", "brain", "and", "increase", "Ca(2+)", "influx", "into", "neurons", ",", "which", "is", "thought", "to", "induce", "dystonia", "and", "mental", "deterioration"], "h": {"id": "C1412215", "name": "C1412215#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415287", "name": "C1415287#ent", "pos": [11, 12]}}
{"token": ["The", "treatment", "with", "the", "Src", "family", "kinase-specific", "inhibitor", "PP1", ",", "or", "C2987155#ent", "<e1>", "inhibitor", ",", "U73122", ",", "or", "C1516869#ent", "<e2>", "heparin", ",", "prevented", "calcium", "release", "the", "extracts", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [18, 19]}}
{"token": ["To", "compare", "the", "C1136254#ent", "<e1>", "effects", "of", "C1321744#ent", "<e2>", "and", "trovafloxacin", "on", "Staphylococcus", "aureus", "their", "pharmacodynamics", "were", "studied", "in", "an", "in", "vitro", "model", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C1321744", "name": "C1321744#ent", "pos": [7, 8]}}
{"token": ["The", "newest", "C1136254#ent", "<e1>", "reviewed", "herein", "(", "linezolid", ",", "quinupristin/dalfopristin", ",", "gatifloxacin", ",", "C1321744#ent", "<e2>", "and", "moxifloxacin", ")", "are", "not", "a", "significant", "improvement", "upon", "older", "agents", "in", "the", "treatment", "of", "SSSIs", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C1321744", "name": "C1321744#ent", "pos": [13, 14]}}
{"token": ["Concomitant", "use", "of", "C0674428#ent", "<e1>", "and", "rifampicin", "is", "common", "for", "treatment", "of", "C0019693#ent", "<e2>", "and", "tuberculosis", "."], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [12, 13]}}
{"token": ["This", "HPLC", "method", "is", "highly", "sensitive", "and", "precise", ",", "suitable", "for", "pharmacokinetic", "studies", "routine", "clinical", "monitoring", "rifampicin", "and", "C0674428#ent", "<e1>", "simultaneously", "in", "C0019693#ent", "<e2>", "patients", "with", "tuberculosis", "."], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [18, 19]}, "relation": "may_prevent", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [22, 23]}}
{"token": ["C0674428#ent", "<e1>", ",", "a", "potent", "nonnucleoside", "reverse", "transcriptase", "inhibitor", "prescribed", "for", "the", "treatment", "of", "C0019693#ent", "<e2>", "produces", "renal", "tubular", "epithelial", "cell", "necrosis", "rats", "but", "not", "in", "cynomolgus", "monkeys", "humans", "."], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [14, 15]}}
{"token": ["C0674428#ent", "<e1>", "is", "a", "non-nucleoside", "reverse", "transcriptase", "inhibitor", "the", "treatment", "of", "the", "C0019693#ent", "<e2>"], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [12, 13]}}
{"token": ["Consistent", "with", "data", ",", "C1708808#ent", "<e1>", "associates", "with", "p59(fyn", ")", ",", "a", "Src", "family", "kinase", "to", "phosphorylate", "C1565427#ent", "<e2>"], "h": {"id": "C1708808", "name": "C1708808#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "we", "demonstrate", "that", "PSTPIP", "serves", "as", "a", "scaffold", "protein", "C1705342#ent", "<e1>", "and", "C1705616#ent", "<e2>", "and", "allows", "C1705342#ent", "<e1>", "to", "dephosphorylate", "C1705616#ent", "<e2>", "."], "h": {"id": "C1705342", "name": "C1705342#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [14, 15]}}
{"token": ["Pulldown", "analysis", "with", "glutathione", "S-transferase-fused", "proline-rich", "regions", "C1705342#ent", "<e1>", "revealed", "coprecipitation", "of", "C1705616#ent", "<e2>", ",", "PYK2", ",", "c-Src", ",", "and", "PSTPIP", "proteins", "with", "the", "N-terminal", "region", "(", "amino", "acids", "-", "497", ")", "of", "C1705342#ent", "<e1>", "."], "h": {"id": "C1705342", "name": "C1705342#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [12, 13]}}
{"token": ["Functional", "alterations", "in", "the", "central", "nervous", "system", "peripheral", "nerves", "well", "documented", "in", "C3665349#ent", "<e1>", "but", "not", "in", "C0020676#ent", "<e2>"], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [17, 18]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "lipid", "profile", "patients", "with", "different", "degrees", "of", "C3665349#ent", "<e1>", "and", "the", "effect", "of", "levothyroxine", "replacement", "C0020676#ent", "<e2>", "SH", ")", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [24, 25]}}
{"token": ["Thus", ",", "adverse", "effects", "maternal", "hypothyroidism", "be", "due", ",", "at", "least", "in", "part", ",", "to", "the", "C3665349#ent", "<e1>", "the", "embryonic", "tissues", "and", "not", "only", "to", "the", "C0020676#ent", "<e2>", "condition", "of", "the", "mother", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [26, 27]}}
{"token": ["Csp", "was", "found", "to", "consist", "of", "371", "amino", "acid", "residues", "in", "the", "mature", "form", "and", "to", "be", "more", "homologous", "to", "C1538565#ent", "<e1>", "than", "to", "C1413662#ent", "<e2>", "."], "h": {"id": "C1538565", "name": "C1538565#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1413662", "name": "C1413662#ent", "pos": [24, 25]}}
{"token": ["We", "gave", "either", "C0026056#ent", "<e1>", "or", "propofol", "for", "induction", "of", "anaesthesia", "to", "140", "C0004057#ent", "<e2>", "II", "female", "patients", "(", "18", "-", "60", "yr", ")", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [13, 14]}}
{"token": ["Propofol", "and", "C0026056#ent", "<e1>", "were", "compared", "for", "intra-operative", "patient-controlled", "sedation", "in", "40", "C0004057#ent", "<e2>", "day", "patients", "undergoing", "surgical", "extraction", "third", "molar", "teeth", "local", "anaesthesia"], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "the", "region", "extending", "from", "-876", "to", "-271bp", "of", "the", "C1416586#ent", "<e1>", "promoter", ",", "appears", "to", "contain", "C1706113#ent", "<e2>", ",", "and", "to", "be", "sufficient", "for", "induction", "by", "1,25D(3", ")", "."], "h": {"id": "C1416586", "name": "C1416586#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706113", "name": "C1706113#ent", "pos": [18, 19]}}
{"token": ["A", "highly", "purified", "C0020364#ent", "<e1>", "reconstituted", "with", "C0008381#ent", "<e2>", "epoxide", "hydrolase", "17", "nmol", "of", "metabolites/nmol", "of", "cytochrome", "P450", "1A1/min", "gave", "a", "metabolite", "profile", "very", "similar", "to", "that", "observed", "with", "liver", "microsomes", "3-methylcholanthrene-treated", "rats", "."], "h": {"id": "C0020364", "name": "C0020364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008381", "name": "C0008381#ent", "pos": [7, 8]}}
{"token": ["C0020364#ent", "<e1>", "in", "the", "C0008381#ent", "<e2>", "induced", "by", "a", "number", "of", "their", "xenobiotic", "substrates", "by", "testosterone", ",", "an", "endobiotic", "substrate", "of", "importance", "in", "their", "regulation", "."], "h": {"id": "C0020364", "name": "C0020364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008381", "name": "C0008381#ent", "pos": [4, 5]}}
{"token": ["Cytochrome", "P450", "the", "mitochondria", "of", "the", "adrenal", "cortex", "functions", "in", "the", "C0020364#ent", "<e1>", "the", "biosynthesis", "of", "various", "steroid", "hormones", "such", "as", "C0008381#ent", "<e2>", "hydroxylation", "at", "11", "beta-position", "and", "that", "at", "18-position", "of", "the", "steroid", "structure"], "h": {"id": "C0020364", "name": "C0020364#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008381", "name": "C0008381#ent", "pos": [21, 22]}}
{"token": ["In", "this", "paper", ",", "we", "introduce", "and", "apply", "a", "new", "Machine", "Learning", "technique", "Logical", "Hidden", "Markov", "Models", "LOHMMs", ")", ",", "to", "the", "C1416596#ent", "<e1>", "of", "finding", "structural", "signatures", "folds", "according", "to", "the", "classification", "scheme", "C1538638#ent", "<e2>", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1538638", "name": "C1538638#ent", "pos": [34, 35]}}
{"token": ["The", "calmodulin", "antagonist", "C0078437#ent", "<e1>", ")", "inhibited", "the", "stimulation-evoked", "norepinephrine", "overflow", "and", "C0237795#ent", "<e2>", "responses", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0078437", "name": "C0078437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [12, 13]}}
{"token": ["Pyrolysis", "GC-MS", "analysis", "of", "polymers", "indicated", "that", "the", "polymerization", "of", "C0031428#ent", "<e1>", "involved", "the", "oxidative", "coupling", "the", "introduced", "C3539991#ent", "<e2>"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539991", "name": "C3539991#ent", "pos": [18, 19]}}
{"token": ["An", "interesting", "occurrence", "in", "11", "patients", "was", "14", "episodes", "of", "reactive", "skin", "manifestations", "Sweet's", "syndrome", "9", ";", "generalized", "pustulosis", "C0014743#ent", "<e1>", "2", "each", ";", "and", "C0343055#ent", "<e2>", "1", ")", "."], "h": {"id": "C0014743", "name": "C0014743#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0343055", "name": "C0343055#ent", "pos": [25, 26]}}
{"token": ["We", "therefore", "assessed", "the", "influence", "of", "C0033017#ent", "<e1>", "PCN", ")", "treatment", "on", "LCA-induced", "hepatotoxicity", "and", "disposition", "of", "C2931258#ent", "<e2>", "metabolites", "using", "female", "farnesoid", "X", "receptor", "and", "wild-type", "mice", "."], "h": {"id": "C0033017", "name": "C0033017#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2931258", "name": "C2931258#ent", "pos": [17, 18]}}
{"token": ["The", "postoperative", "immunochemotherapy", "consisted", "of", "C0010927#ent", "<e1>", "(", "DTIC", ")", ",", "Amino-Methyl-Pyrimidinyl-Methyl-Chlorethyl-Nitrosourea-Hydrochlori", "de", "(", "C0771987#ent", "<e2>", ")", ",", "Vincristine", "(", "VCR", ")", "and", "OK-432", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0771987", "name": "C0771987#ent", "pos": [14, 15]}}
{"token": ["A", "mismatch", "recognition", "complex", "composed", "of", "MSH2", ",", "MSH6", ",", "MLH1", ",", "PMS2", "and", "PCNA", ",", "is", "formed", "after", "exposing", "MGMT-deficient", "cells", "to", "C0010927#ent", "<e1>", ",", "but", "not", "in", "cells", "treated", "with", "C0771987#ent", "<e2>", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0771987", "name": "C0771987#ent", "pos": [32, 33]}}
{"token": ["After", "administering", "systemic", "chemotherapy", "C0010927#ent", "<e1>", "(", "DTIC", ")", ",", "vincristine", "sulfate", "VCR", ")", ",", "and", "C0771987#ent", "<e2>", "ACNU", ")", "plus", "interferon-beta", ",", "the", "esophageal", "tumor", "decreased", "in", "size", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0771987", "name": "C0771987#ent", "pos": [16, 17]}}
{"token": ["C0029166#ent", "<e1>", "methemoglobinaemia", ")", "rapidly", "regressed", "after", "withdrawal", "of", "C0010980#ent", "<e2>", "but", "this", "was", "followed", "by", "another", "exacerbation", "of", "the", "disease", ",", "resulting", "in", "a", "therapeutic", "impasse", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [9, 10]}}
{"token": ["mtDNA", "duplications", "detectable", "in", "10", "of", "10", "patients", "with", "mtDNA", "deletions", "and", "Kearns-Sayre", "syndrome", "C0022541#ent", "<e1>", ")", "and", "in", "none", "of", "8", "patients", "with", "chronic", "progressive", "external", "ophthalmoplegia", "C0162674#ent", "<e2>", ")", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [28, 29]}}
{"token": ["The", "mode", "of", "inheritance", "of", "C0022541#ent", "<e1>", "KSS", ")", "and", "chronic", "progressive", "external", "ophthalmoplegia", "C0162674#ent", "<e2>", ")", "have", "not", "yet", "been", "established", ",", "since", "most", "cases", "are", "sporadic", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [14, 15]}}
{"token": ["mtDNA", "duplications", "detectable", "in", "10", "of", "10", "patients", "with", "mtDNA", "deletions", "and", "C0022541#ent", "<e1>", "KSS", ")", "and", "in", "none", "of", "8", "patients", "with", "C0162674#ent", "<e2>", "CPEO", ")", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [23, 24]}}
{"token": ["The", "thoracic", "outlet", "syndrome", "the", "C0027743#ent", "<e1>", "the", "popliteal", "artery", "two", "major", "examples", "of", "C1861783#ent", "<e2>"], "h": {"id": "C0027743", "name": "C0027743#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1861783", "name": "C1861783#ent", "pos": [14, 15]}}
{"token": ["Management", "strategies", "for", "abdominal", "stab", "wounds", "C1824114#ent", "<e1>", ")", "in", "initially", "asymptomatic", "patients", "range", "from", "mandatory", "explorative", "laparotomy", "C1823249#ent", "<e2>", ")", "to", "conservative", "approaches", "with", "observation", "alone", "."], "h": {"id": "C1824114", "name": "C1824114#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1823249", "name": "C1823249#ent", "pos": [18, 19]}}
{"token": ["The", "C0237795#ent", "<e1>", "response", "to", "choline", "was", "blocked", "by", "pretreatment", "with", "C0018983#ent", "<e2>", "(", "20", "micrograms", ",", "i.c.v", ".", ")", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018983", "name": "C0018983#ent", "pos": [11, 12]}}
{"token": ["The", "C0237795#ent", "<e1>", "responses", "to", "bicuculline", "methiodide", "animals", "pre-treated", "with", "C0018983#ent", "<e2>", "were", "significantly", "higher", "than", "those", "seen", "in", "saline-pre-treated", "groups", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018983", "name": "C0018983#ent", "pos": [10, 11]}}
{"token": ["The", "C0237795#ent", "<e1>", "responses", "to", "bicuculline", "methiodide", "animals", "pretreated", "with", "the", "C0018983#ent", "<e2>", "were", "higher", "than", "those", "seen", "in", "saline-pretreated", "groups", ",", "but", "locomotor", "activity", "heart", "rate", "to", "bicuculline", "methiodide", "unchanged", "in", "C0018983#ent", "<e2>", "pretreatment", "group", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018983", "name": "C0018983#ent", "pos": [11, 12]}}
{"token": ["Further", ",", "NC", "displayed", "a", "better", "effect", "than", "C1706141#ent", "<e1>", "because", "the", "C1254351#ent", "<e2>", "was", "entrapped", "in", "the", "oily", "core", "of", "the", "carrier", ",", "thus", "more", "readily", "available", "to", "the", "eye", "."], "h": {"id": "C1706141", "name": "C1706141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["For", "each", "patient", ",", "the", "following", "data", "were", "noted", ":", "sex", ",", "use", "of", "C0003290#ent", "<e1>", "atopy", ",", "amount", "of", "administered", "C0033487#ent", "<e2>", "and", "the", "effective", "intensity", "of", "the", "electric", "shock"], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [21, 22]}}
{"token": ["Blood", "pressure", "heart", "rate", "supine", "and", "standing", ",", "were", "studied", "in", "patients", "with", "C0085580#ent", "<e1>", "8", "weeks", "of", "oral", "therapy", "two", "dosage", "schedules", "of", "C1517662#ent", "<e2>", ",", "40", "mg", "once", "and", "twice", "daily", "."], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [24, 25]}}
{"token": ["Twenty-one", "patients", "with", "C0085580#ent", "<e1>", "given", "oral", "C1517662#ent", "<e2>", "(", "40", "mg", ")", "once", "or", "twice", "daily", "for", "4", "weeks", "after", "a", "2", "-", "4-week", "single-blind", "control", "period"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [7, 8]}}
{"token": ["Finally", ",", "cephalexin", "represents", "an", "additional", "valuable", "antibacterial", "drug", "postcoital", "prophylaxis", "along", "with", "C0041044#ent", "<e1>", ",", "nitrofurantoin", "and", "C0014310#ent", "<e2>", "."], "h": {"id": "C0041044", "name": "C0041044#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014310", "name": "C0014310#ent", "pos": [18, 19]}}
{"token": ["Stimulation", "of", "immature", "DCs", "by", "SP-A", "also", "inhibits", "the", "allostimulation", "of", "T", "cells", "enhances", "C0011806#ent", "<e1>", "endocytosis", ",", "and", "alters", "DC", "chemotaxis", "toward", "C1332691#ent", "<e2>", "and", "secondary", "lymphoid", "tissue", "chemokine"], "h": {"id": "C0011806", "name": "C0011806#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [23, 24]}}
{"token": ["Sequence-specific", "assignment", "of", "the", "1H-", "and", "13C-NMR", "signals", "of", "C0220413#ent", "<e1>", "in", "a", "C0001962#ent", "<e2>", "solution", "was", "achieved", "by", "using", "the", "two-dimensional", "NMR", "technique"], "h": {"id": "C0220413", "name": "C0220413#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [13, 14]}}
{"token": ["Promising", "new", "C0991617#ent", "<e1>", "like", "candins", ",", "sordarins", ",", "high", "dose", "oral", "C0771029#ent", "<e2>", ",", "the", "third", "generation", "azoles", ",", "and", "liposomal", "nystatin", "under", "development", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0771029", "name": "C0771029#ent", "pos": [12, 13]}}
{"token": ["The", "2", "most", "common", "C0991617#ent", "<e1>", "used", "to", "treat", "dermatophyte", "onychomycosis", "the", "toe", "are", "C0771029#ent", "<e2>", "(", "continuous", ")", "and", "itraconazole", "(", "pulse", ")", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0771029", "name": "C0771029#ent", "pos": [14, 15]}}
{"token": ["The", "new", "C0991617#ent", "<e1>", ",", "fluconazole", ",", "itraconazole", ",", "and", "C0771029#ent", "<e2>", ",", "have", "definitely", "improved", "the", "treatment", "of", "tinea", "unguium"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0771029", "name": "C0771029#ent", "pos": [10, 11]}}
{"token": ["We", "report", "two", "patients", "with", "C0022661#ent", "<e1>", "a", "pre-dialyzed", "stage", "who", "developed", "C0038220#ent", "<e2>", "ingestion", "of", "star", "fruit"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [12, 13]}}
{"token": ["Recombination", "rates", "that", "were", "associated", "with", "C1413845#ent", "<e1>", "mutants", "co-segregated", "with", "the", "particular", "C0002085#ent", "<e2>", "following", "meiosis", ",", "and", "comparable", "recombination", "patterns", "were", "also", "observed", "for", "independently", "isolated", ",", "identical", "mutations", "."], "h": {"id": "C1413845", "name": "C1413845#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "a", "case", "of", "C0027849#ent", "<e1>", "a", "patient", "who", "had", "Escherichia", "coli", "C0036690#ent", "<e2>", "caused", "by", "thioridazine", "."], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [13, 14]}}
{"token": ["C0040822#ent", "<e1>", "elicited", "by", "systemic", "administration", "C0022471#ent", "<e2>", "eliminated", "by", "bilateral", "destruction", "ventral", "dentate", "granule", "cells", "."], "h": {"id": "C0040822", "name": "C0040822#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [6, 7]}}
{"token": ["An", "intense", "hepatocellular", "C1417760#ent", "<e1>", "reactivity", "was", "detected", "in", "C0524909#ent", "<e2>", "whereas", "it", "was", "weakly", "or", "not", "observed", "in", "nonviral", "liver", "disease", "normal", "liver", ",", "respectively", "."], "h": {"id": "C1417760", "name": "C1417760#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [9, 10]}}
{"token": ["We", "compared", "the", "inducible", "NO", "synthase", "C1417760#ent", "<e1>", ")", "expression", "in", "the", "liver", "of", "patients", "with", "C0524909#ent", "<e2>", "that", "of", "both", "nonviral", "liver", "disease", "histologically", "normal", "liver", "."], "h": {"id": "C1417760", "name": "C1417760#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [16, 17]}}
{"token": ["Early", "side", "effects", "common", "when", "C0033148#ent", "<e1>", "is", "used", "to", "treat", "C0270736#ent", "<e2>", "with", "as", "many", "as", "one-third", "of", "patients", "failing", "to", "tolerate", "the", "tablets", "."], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0270736", "name": "C0270736#ent", "pos": [11, 12]}}
{"token": ["Propranolol", "and", "C0033148#ent", "<e1>", "are", "widely", "used", ",", "effective", "agents", "in", "C0270736#ent", "<e2>", "they", "are", "not", "tolerated", "by", "all", "patients", "."], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0270736", "name": "C0270736#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "propranolol", "and", "C0033148#ent", "<e1>", "are", "effective", "long-term", "treatment", "for", "some", "patients", "with", "C0270736#ent", "<e2>"], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0270736", "name": "C0270736#ent", "pos": [15, 16]}}
{"token": ["At", "Week", "2", ",", "the", "diflorasone", "diacetate", "group", "improved", "significantly", "more", "than", "the", "C0750848#ent", "<e1>", "group", "with", "respect", "to", "C0033775#ent", "<e2>", "."], "h": {"id": "C0750848", "name": "C0750848#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0033775", "name": "C0033775#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "reelin", "cleavage", "insensitive", "to", "inhibitors", "of", "matrixins", ",", "neprilysin", ",", "C0733413#ent", "<e1>", ",", "and", "peptidyl", "dipeptidase", "A", "suggesting", "that", "the", "processing", "C0027203#ent", "<e2>", "belongs", "to", "a", "different", "enzyme", "family", "."], "h": {"id": "C0733413", "name": "C0733413#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [23, 24]}}
{"token": ["The", "C0243046#ent", "<e1>", "aspartate/glutamate", "content", "of", "septal", "complex", "calretinin", "(CR)-", ",", "C0008407#ent", "<e2>", "substance", "P-", ",", "and", "Leu-enkephalin", "(Leu-enk)-containing", "extrinsic", "afferents", "was", "examined", "."], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008407", "name": "C0008407#ent", "pos": [11, 12]}}
{"token": ["C0243046#ent", "<e1>", "significantly", "reduced", "the", "activity", "of", "C0008407#ent", "<e2>", "the", "hippocampus", "3", "to", "28", "days", "following", "intraventricular", "infusion", ",", "but", "not", "in", "the", "striatum", "or", "parahippocampal", "cortex"], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008407", "name": "C0008407#ent", "pos": [7, 8]}}
{"token": ["Together", ",", "our", "findings", "identified", "a", "novel", "interaction", "of", "C1367307#ent", "<e1>", "with", "Ec-gp96", ",", "upstream", "of", "C2713509#ent", "<e2>", "and", "PKC-alpha", "activation", "that", "is", "required", "for", "the", "invasion", "of", "E.", "coli", "HBMEC", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [16, 17]}}
{"token": ["To", "reduce", "such", "effects", ",", "we", "recently", "coated", "a", "C0056248#ent", "<e1>", "carotid", "and", "the", "distal", "femoral", "artery", "rats", "with", "C1412332#ent", "<e2>", "."], "h": {"id": "C0056248", "name": "C0056248#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [19, 20]}}
{"token": ["Recent", "interest", "has", "focused", "on", "the", "use", "of", "C0003195#ent", "<e1>", "such", "as", "C0700442#ent", "<e2>"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}, "relation": "therapeutic_class_of", "t": {"id": "C0700442", "name": "C0700442#ent", "pos": [12, 13]}}
{"token": ["This", "finding", "suggests", "that", "C1332804#ent", "<e1>", "play", "an", "important", "role", "in", "amyloid", "fibrilogenesis", "converting", "C1419798#ent", "<e2>", "to", "AA", "."], "h": {"id": "C1332804", "name": "C1332804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419798", "name": "C1419798#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "when", "expression", "of", "C1421976#ent", "<e1>", "was", "regulated", "by", "an", "intermediate", "promoter", "no", "C0005220#ent", "<e2>", "was", "detected", "even", "though", "C1421976#ent", "<e1>", "transcripts", "were", "present", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "dominant", "negative", "mutant", "of", "C0079972#ent", "<e1>", "almost", "completely", "abrogated", "VEGF-induced", "activation", "of", "ERK", "and", "C0257535#ent", "<e2>", "HMVECs", "."], "h": {"id": "C0079972", "name": "C0079972#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [17, 18]}}
{"token": ["Although", "dominant", "negative", "mutant", "of", "C0079972#ent", "<e1>", "substantially", "inhibited", "the", "basal", "activities", "ERK", "and", "C0257535#ent", "<e2>", "it", "exhibited", "marginal", "effect", "VEGF-induced", "activation", "of", "ERK", "and", "C0257535#ent", "<e2>", "HUVECs", "and", "HAECs", "."], "h": {"id": "C0079972", "name": "C0079972#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [14, 15]}}
{"token": ["C0242430#ent", "<e1>", "but", "not", "C0010620#ent", "<e2>", "abolished", "the", "enhanced", "activity", "of", "the", "flexor", "reflex"], "h": {"id": "C0242430", "name": "C0242430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010620", "name": "C0010620#ent", "pos": [4, 5]}}
{"token": ["The", "inhibition", "of", "food", "intake", "loading", "55", "g", "C1412125#ent", "<e1>", "into", "the", "rumen", "was", "not", "affected", "by", "injecting", "C0546869#ent", "<e2>", "the", "reticulum", "immediately", "before", "C1412125#ent", "<e1>", "loading", "."], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0546869", "name": "C0546869#ent", "pos": [18, 19]}}
{"token": ["We", "assessed", "the", "incidence", "of", "grade", "2", "higher", "C0020631#ent", "<e1>", "in", "the", "HIV", "Outpatient", "Study", "(", "C0268412#ent", "<e2>", ")", "."], "h": {"id": "C0020631", "name": "C0020631#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268412", "name": "C0268412#ent", "pos": [16, 17]}}
{"token": ["There", "was", "no", "significant", "group", "x", "time", "interaction", "C1417541#ent", "<e1>", "or", "titin", "C0597298#ent", "<e2>", "expression", "."], "h": {"id": "C1417541", "name": "C1417541#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [12, 13]}}
{"token": ["Hereditary", "tyrosinaemia", "type", "I", "a", "severe", "autosomal", "recessive", "metabolic", "disease", "affects", "the", "C0023899#ent", "<e1>", "and", "kidneys", "and", "is", "caused", "by", "deficiency", "of", "fumarylacetoacetate", "hydrolase", "C1414527#ent", "<e2>", ")", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414527", "name": "C1414527#ent", "pos": [24, 25]}}
{"token": ["Overall", ",", "highest", "formation", "of", "the", "16:0", "FAA", "was", "found", "in", "the", "C0023899#ent", "<e1>", "followed", "by", "pancreas", "and", "of", "18:1", "C1414527#ent", "<e2>", "in", "the", "whole", "blood", "brown", "fat"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414527", "name": "C1414527#ent", "pos": [20, 21]}}
{"token": ["Four", "weeks", "of", "C0011849#ent", "<e1>", "reduced", "basal", "insulin", "receptor", "kinase", "insulin", "receptor", "substrate", "phosphatidylinositol", "3-kinase", "and", "Akt", "kinase", "activity", "altering", "C1334133#ent", "<e2>", "IRS-1/2", "expression", "or", "tyrosine", "phosphorylation"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [20, 21]}}
{"token": ["Tertian", "and", "quartan", "C0024530#ent", "<e1>", "are", "treated", "by", "chloroquine", ",", "falciparum", "C0024530#ent", "<e1>", "by", "quinine", ",", "mefloquine", "or", "C0120726#ent", "<e1>", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0120726", "name": "C0120726#ent", "pos": [18, 19]}}
{"token": ["Fifty", "subjects", "with", "acute", "uncomplicated", "falciparum", "C0024530#ent", "<e1>", "were", "treated", "orally", "with", "a", "new", "micronized", "formulation", "of", "C0120726#ent", "<e2>", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0120726", "name": "C0120726#ent", "pos": [17, 18]}}
{"token": ["Using", "pervanadate", "as", "a", "means", "to", "phosphorylate", "the", "C2826538#ent", "<e1>", "cytoplasmic", "tail", "we", "observed", "both", "Src", "homology", "protein", "(SHP)-1", "and", "C1566685#ent", "<e2>", "recruitment", "."], "h": {"id": "C2826538", "name": "C2826538#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1566685", "name": "C1566685#ent", "pos": [20, 21]}}
{"token": ["The", "following", "loci", "could", "not", "be", "localized", "with", "full", "confidence", ":", "LDHA", ",", "NP", ",", "C1418462#ent", "<e1>", ",", "ITP", ",", "and", "C4084713#ent", "<e2>", "."], "h": {"id": "C1418462", "name": "C1418462#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4084713", "name": "C4084713#ent", "pos": [21, 22]}}
{"token": ["In", "HeLa", "cells", "recombinant", "human", "concentrative", "nucleoside", "transporter", "C3272517#ent", "<e1>", ")", "1", "or", "hCNT3", "and", "pharmacologically", "blocked", "C1420171#ent", "<e2>", "and", "hENT2", ",", "transport", "of", "10", "microM[3H]TaraC", "and", "[3H]araC", "was", "not", "detected", "."], "h": {"id": "C3272517", "name": "C3272517#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420171", "name": "C1420171#ent", "pos": [17, 18]}}
{"token": ["We", "have", "investigated", "the", "release", "of", "C1705556#ent", "<e1>", "through", "hemichannels", "from", "Xenopus", "oocytes", "are", "formed", "by", "C0532207#ent", "<e2>", "Cx38", ")", ",", "an", "endogenous", ",", "specific", "type", "of", "connexin", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0532207", "name": "C0532207#ent", "pos": [16, 17]}}
{"token": ["Effects", "of", "baicalein", "and", "wogonin", ",", "the", "major", "C1257966#ent", "<e1>", "of", "Scutellariae", "radix", "on", "cytochrome", "P450", "C0010762#ent", "<e2>", ")", ",", "UDP-glucuronosyl", "transferase", "UGT", ")", ",", "and", "glutathione", "S-transferase", "GST", ")", "were", "studied", "in", "C57BL/6J", "mice"], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [16, 17]}}
{"token": ["Multiple", "proteins", "in", "the", "Rho/Rho-associated", ",", "coiled", "coil-containing", "protein", "kinase", "Rock", ")", "signal", "transduction", "pathway", "found", "to", "be", "immunogenic", ",", "including", "Rock1", ",", "C1412528#ent", "<e1>", "and", "schistosoma", "mansoni", "adult", "C0018889#ent", "<e2>", "70", "."], "h": {"id": "C1412528", "name": "C1412528#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [29, 30]}}
{"token": ["Four", "common", "clinical", "presentations", "C0010346#ent", "<e1>", "acute", "exacerbations", "flares", "of", "disease", ",", "C0021843#ent", "<e2>", "fistulizing", "disease", ",", "and", "perianal", "disease"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0021843", "name": "C0021843#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "2", "patients", "previously", "diagnosed", "with", "C0010346#ent", "<e1>", "inadequate", "response", "to", "treatment", ",", "who", "showed", "C0021843#ent", "<e2>", "in", "the", "ileum", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0021843", "name": "C0021843#ent", "pos": [16, 17]}}
{"token": ["Severe", "C1175175#ent", "<e1>", "SARS", ")", "is", "caused", "by", "a", "novel", "and", "highly", "C0042769#ent", "<e2>", "SARS", "coronavirus", "SARS-CoV", ")", "."], "h": {"id": "C1175175", "name": "C1175175#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [12, 13]}}
{"token": ["The", "authors", "summarize", "results", "of", "trials", "with", "acetysalicyl", "acid", "(", "C0007804#ent", "<e1>", ")", "in", "patients", "with", "ischaemic", "heart", "disease", "in", "particular", "with", "C0264716#ent", "<e2>"], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0264716", "name": "C0264716#ent", "pos": [22, 23]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "evaluate", "the", "effect", "of", "the", "IL-6", "-174", "G/C", "polymorphism", "hemostatic", "or", "inflammatory", "markers", "patients", "with", "C1306889#ent", "<e1>", "PAOD", ")", ",", "a", "common", "manifestation", "of", "C0003850#ent", "<e2>"], "h": {"id": "C1306889", "name": "C1306889#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [31, 32]}}
{"token": ["The", "prevalence", "of", "clinical", "and", "sub-clinical", "C1306889#ent", "<e1>", "of", "risk", "factors", "in", "the", "pathogenesis", "of", "C0003850#ent", "<e2>", "was", "assessed", "in", "21", "patients", "with", "chronic", "renal", "failure", "27", "on", "maintenance", "haemodialysis", "and", "51", "renal", "allograft", "recipients", "."], "h": {"id": "C1306889", "name": "C1306889#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [15, 16]}}
{"token": ["C2717961#ent", "<e1>", "acute", "renal", "failure", "cardinal", "features", "of", "post-diarrheal", "hemolytic", "uremic", "syndrome", "C3273279#ent", "<e2>", ")", "."], "h": {"id": "C2717961", "name": "C2717961#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273279", "name": "C3273279#ent", "pos": [12, 13]}}
{"token": ["In", "vitro", "binding", "of", "C1826259#ent", "<e1>", "to", "ChoRE-containing", "oligonucleotides", "observed", "only", "in", "the", "presence", "of", "C3539691#ent", "<e2>", "."], "h": {"id": "C1826259", "name": "C1826259#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539691", "name": "C3539691#ent", "pos": [15, 16]}}
{"token": ["The", "most", "frequent", "origin", "of", "the", "infection", "was", "C0008325#ent", "<e1>", "in", "50", "%", "of", "patients", "and", "C0013502#ent", "<e2>", "20", "%", "."], "h": {"id": "C0008325", "name": "C0008325#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [16, 17]}}
{"token": ["C0286737#ent", "<e1>", "treatment", "prevented", "LPS/IFN-gamma-induced", "activation", "of", "C1417708#ent", "<e2>", "in", "RAW", "cells", "and", "stabilized", "expression", "of", "IkappaBalpha", "."], "h": {"id": "C0286737", "name": "C0286737#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [7, 8]}}
{"token": ["Rats", "placed", "on", "the", "C1839259#ent", "<e1>", "14", "days", "after", "KA-induced", "C1414863#ent", "<e2>", "did", "not", "differ", "from", "controls", "with", "regard", "to", "spontaneous", "seizure", "rate", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "C0079594#ent", "<e1>", ",", "a", "stable", "analogue", "of", "C0205911#ent", "<e2>", ",", "reversed", "the", "aspirin", "inhibitory", "effects", "on", "fibrinolytic", "activity", "restoring", "t-PA", "vascular", "release", "after", "venous", "stasis"], "h": {"id": "C0079594", "name": "C0079594#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [9, 10]}}
{"token": ["C0079594#ent", "<e1>", "--", "a", "stable", "analogue", "of", "C0205911#ent", "<e2>", "(", "10", "microg/kg", "i.v", ".", ")"], "h": {"id": "C0079594", "name": "C0079594#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [7, 8]}}
{"token": ["C1705772#ent", "<e1>", "also", "forms", "heterodimers", "with", "C0162508#ent", "<e2>", "but", "not", "with", "Fos", "."], "h": {"id": "C1705772", "name": "C1705772#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "C1705772#ent", "<e1>", "could", "form", "a", "complex", "with", "C0162508#ent", "<e2>", "but", "not", "with", "c-Fos", "."], "h": {"id": "C1705772", "name": "C1705772#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [10, 11]}}
{"token": ["This", "case", "demonstrates", "that", "spontaneous", "C0840564#ent", "<e1>", "be", "a", "rare", "cause", "of", "abdominal", "complaints", "C0243026#ent", "<e2>", "when", "the", "etiology", "at", "first", "seems", "unclear", "."], "h": {"id": "C0840564", "name": "C0840564#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [14, 15]}}
{"token": ["Nine", "months", "later", "she", "again", "presented", "with", "an", "intraperitoneal", "C0840564#ent", "<e1>", "pregnancy", "and", "fatal", "C0243026#ent", "<e2>", "."], "h": {"id": "C0840564", "name": "C0840564#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [14, 15]}}
{"token": ["A", "42-year-old", "patient", "with", "a", "regenerative", "erythroblastopenic", "anaemia", "(", "7", "g", "%", "Hb", ")", ",", "considered", "as", "C0034902#ent", "<e1>", "PRCA", ")", "is", "submitted", "to", "an", "immunosuppressive", "treatment", "C1161438#ent", "<e2>", "+", "prednisone", ")", "."], "h": {"id": "C0034902", "name": "C0034902#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [27, 28]}}
{"token": ["Two", "patients", "with", "C0034902#ent", "<e1>", "PRCA", ")", "refractory", "to", "anti-thymocyte", "globulin", "prednisolone", ",", "C1161438#ent", "<e2>", ",", "fludarabine", ",", "mitoxantrone", ",", "dexamethasone", "and", "cyclosporine", ",", "were", "treated", "with", "alemtuzumab", "(", "anti-CD52", "antibody", "."], "h": {"id": "C0034902", "name": "C0034902#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [13, 14]}}
{"token": ["The", "management", "of", "Tourette's", "syndrome", "become", "more", "effective", "with", "the", "availability", "of", "least", "two", "C0033978#ent", "<e1>", "haloperidol", "and", "C0031935#ent", "<e2>", "."], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [18, 19]}}
{"token": ["The", "results", "suggest", "that", "C0033978#ent", "<e1>", "such", "as", "haloperidol", "and", "C0031935#ent", "<e2>", ",", "can", ",", "like", "substituted", "benzamides", "stimulate", "TSH", "release", "in", "man", "."], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [10, 11]}}
{"token": ["Important", "adverse", "skin", "reactions", "C0406650#ent", "<e1>", "LABD", ")", "and", "C0038325#ent", "<e2>", "SJS", ")", "."], "h": {"id": "C0406650", "name": "C0406650#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038325", "name": "C0038325#ent", "pos": [9, 10]}}
{"token": ["Myotonic", "dystrophy", "protein", "kinase", "C1414085#ent", "<e1>", ")", "is", "a", "C1439287#ent", "<e2>", "by", "the", "myotonic", "dystrophy", "DM", ")", "locus", "on", "human", "chromosome", "19q13.3"], "h": {"id": "C1414085", "name": "C1414085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1439287", "name": "C1439287#ent", "pos": [9, 10]}}
{"token": ["2367", "cases", "of", "C0025289#ent", "<e1>", "and", "571", "of", "C0014038#ent", "<e2>", "were", "reported", "in", "Poland", "in", "2001", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [8, 9]}}
{"token": ["Ten", "patients", "with", "C0025289#ent", "<e1>", "and", "one", "patient", "with", "C0014038#ent", "<e2>", "associated", "with", "mumps", "virus", "infection", "studied", "and", "nine", "patients", "had", "mumps", "virus", "antibody", "their", "cerebrospinal", "fluids", "19", "-", "36", "days", "after", "onset", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [9, 10]}}
{"token": ["We", "had", "previously", "reported", "that", "C0042588#ent", "<e1>", "always", "complicated", "with", "C0149880#ent", "<e2>", "so", "this", "case", "could", "provide", "important", "evidence", "that", "C0042588#ent", "<e1>", "precede", "C0149880#ent", "<e2>"], "h": {"id": "C0149880", "name": "C0149880#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042588", "name": "C0042588#ent", "pos": [5, 6]}}
{"token": ["A", "number", "of", "Phase", "II", "III", "clinical", "studies", "documented", "invasive", "candidiasis", "esophageal", "candidiasis", "and", "C0276653#ent", "<e1>", "been", "completed", "and", "have", "demonstrated", "efficacy", "for", "C0935942#ent", "<e2>", "against", "all", "three", "diseases", "."], "h": {"id": "C0276653", "name": "C0276653#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0935942", "name": "C0935942#ent", "pos": [23, 24]}}
{"token": ["To", "evaluate", "the", "burden", "of", "illness", "of", "narcolepsy", "and", "assess", "the", "C0518214#ent", "<e1>", "HQL", ")", "effects", "of", "oral", "modafinil", ",", "a", "C3658225#ent", "<e2>", "excessive", "daytime", "sleepiness", "associated", "with", "narcolepsy", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3658225", "name": "C3658225#ent", "pos": [21, 22]}}
{"token": ["Side", "effects", "similar", "to", "C1412791#ent", "<e1>", "except", "for", "C0234233#ent", "<e2>", "the", "first", "2", "months", "of", "use", "and", "skin", "irritation", "the", "application", "site"], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0234233", "name": "C0234233#ent", "pos": [8, 9]}}
{"token": ["Transforming", "growth", "factor-beta", "TGF-beta", ")", "and", "the", "renin-angiotensin", "system", "C0525678#ent", "<e1>", ")", "have", "both", "been", "implicated", "in", "the", "pathogenesis", "of", "C0022661#ent", "<e2>"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [20, 21]}}
{"token": ["To", "C0020538#ent", "<e1>", "chronic", "heart", "failure", "had", "been", "treated", "with", "mg", "ramipril", "and", "12.5", "mg", "C0020261#ent", "<e2>", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [15, 16]}}
{"token": ["Forty-four", "patients", "with", "uncomplicated", "C0020538#ent", "<e1>", "48-hour", "electrocardiographic", "monitoring", "and", "after", "four", "weeks", "of", "treatment", "with", "C0020261#ent", "<e2>", ",", "100", "mg", "daily", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [16, 17]}}
{"token": ["When", "she", "was", "about", "30", "years", "old", ",", "she", "began", "to", "notice", "significant", "morning", "stiffness", "C0162323#ent", "<e1>", ",", "and", "progressive", "destructive", "C0035012#ent", "<e2>", "changes", "in", "the", "bilateral", "fingers", "wrists", ",", "and", "left", "ankle"], "h": {"id": "C0162323", "name": "C0162323#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [21, 22]}}
{"token": ["The", "typical", "radiological", "appearances", "are", "discussed", "and", "the", "differential", "diagnosis", "other", "forms", "of", "C0162323#ent", "<e1>", "such", "as", "gout", ",", "psoariatic", "arthropathy", "C0035012#ent", "<e2>", "erosive", "osteoarthritis", "considered", "."], "h": {"id": "C0162323", "name": "C0162323#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [21, 22]}}
{"token": ["One", "of", "their", "siblings", "had", "C0162323#ent", "<e1>", "and", "one", "incomplete", "C0035012#ent", "<e2>"], "h": {"id": "C0162323", "name": "C0162323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [10, 11]}}
{"token": ["It", "was", "found", "that", "AKT", "activation", "induces", "C2349086#ent", "<e1>", "and", "HIF-1", "expression", "through", "its", "two", "downstream", "molecules", "C0812222#ent", "<e2>", "and", "p70S6K1", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [17, 18]}}
{"token": ["The", "mRNAs", "code", "for", "several", "functional", "classes", "of", "proteins", "linked", "to", "cardiac", "hypertrophy", "the", "transcription", "factors", "c-myc", ",", "c-jun", "and", "MEF2D", ",", "growth", "factors", "C2349086#ent", "<e1>", "and", "FGF-2", "and", "the", "E3", "ubiquitin", "ligase", "C0812222#ent", "<e2>", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [33, 34]}}
{"token": ["To", "assess", "whether", "C2349086#ent", "<e1>", "mediated", "angiogenesis", "is", "regulated", "by", "C0812222#ent", "<e2>", ",", "we", "treated", "the", "GI-101A", "and", "HL-60", "cells", "HDM2", "gene", "antisense", "phosphorothioate", "oligodeoxynucleotide", "AS5", ")", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [10, 11]}}
{"token": ["The", "C1522419#ent", "<e1>", "21OH", ")", "is", "the", "main", "C1413096#ent", "<e2>", "in", "autoimmune", "primary", "adrenal", "failure", "(", "Addison's", "disease", "."], "h": {"id": "C1522419", "name": "C1522419#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [8, 9]}}
{"token": ["However", ",", "a", "component", "of", "the", "C1413043#ent", "<e1>", "+", "desensitization", "attributed", "to", "C1418929#ent", "<e2>", "activation", "in", "intact", "tissues", "appeared", "to", "involve", "a", "MLC", "phosphorylation-independent", "component", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418929", "name": "C1418929#ent", "pos": [12, 13]}}
{"token": ["In", "cells", "expressing", "the", "neuronal", ",", "S2", "+", "splice", "variant", "the", "InsP3R-1", ",", "C1413043#ent", "<e1>", "+", "release", "was", "markedly", "enhanced", "when", "either", "PKA", "or", "C1418929#ent", "<e2>", "was", "activated", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418929", "name": "C1418929#ent", "pos": [24, 25]}}
{"token": ["The", "majority", "of", "the", "worms", "recovered", "were", "expelled", "during", "the", "first", "day", "from", "horses", "treated", "with", "ivermectin", "or", "C0034237#ent", "<e1>", "and", "during", "the", "second", "day", "from", "horses", "treated", "with", "C0015821#ent", "<e2>", "."], "h": {"id": "C0034237", "name": "C0034237#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0015821", "name": "C0015821#ent", "pos": [29, 30]}}
{"token": ["This", "C0036572#ent", "<e1>", "a", "newly", "proposed", "C3280428#ent", "<e2>", "association", ",", "an", "extremely", "rare", "condition", "composed", "of", "tracheal", "agenesis", "cardiac", ",", "renal", "and", "duodenal", "malformations"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C3280428", "name": "C3280428#ent", "pos": [6, 7]}}
{"token": ["The", "muscarinic", "antagonists", "atropine", "and", "scopolamine", ",", "intensified", "the", "hyperexcitable", "phase", "and", "potentiated", "the", "C0007384#ent", "<e1>", "effects", "of", "C1414110#ent", "<e2>", "."], "h": {"id": "C0007384", "name": "C0007384#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414110", "name": "C1414110#ent", "pos": [18, 19]}}
{"token": ["We", "have", "conducted", "a", "population-based", "study", "Iceland", "of", "the", "risk", "of", "C0014544#ent", "<e1>", "after", "a", "C0162869#ent", "<e2>", "address", "these", "questions", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162869", "name": "C0162869#ent", "pos": [15, 16]}}
{"token": ["A", "retrospective", "analysis", "of", "the", "incidence", "of", "early", "postoperative", "seizures", "and", "C0014544#ent", "<e1>", "performed", "in", "the", "populations", "of", "patients", "with", "C0162869#ent", "<e2>", "with", "unruptured", "aneurysms", "an", "average", "follow-up", "of", "2.4", "years", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162869", "name": "C0162869#ent", "pos": [20, 21]}}
{"token": ["Again", "C0125656#ent", "<e1>", "reduced", "the", "electrically", "evoked", "overflow", "of", "tritium", "from", "C1883559#ent", "<e2>", "not", "alpha(2A)-knockout", "preparations", "."], "h": {"id": "C0125656", "name": "C0125656#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [11, 12]}}
{"token": ["In", "CA1", ",", "the", "activation", "induced", "by", "C0058678#ent", "<e1>", "about", "threefold", "greater", "than", "that", "induced", "by", "C0205812#ent", "<e2>", ";", "identical", "concentrations", "and", "similar", "currents", "were", "used", "."], "h": {"id": "C0058678", "name": "C0058678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [16, 17]}}
{"token": ["In", "the", "CA1", "as", "well", "as", "in", "the", "CA3", "region", ",", "C0058678#ent", "<e1>", "about", "3", "times", "more", "potent", "than", "C0205812#ent", "<e2>", "."], "h": {"id": "C0058678", "name": "C0058678#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [19, 20]}}
{"token": ["Consistent", "with", "role", "as", "a", "global", "regulator", "expression", "of", "C1327841#ent", "<e1>", "from", "even", "a", "low-copy", "plasmid", "can", "suppress", "C0596543#ent", "<e2>", "production", "in", "Ecc", "and", "Eca", "and", "motility", "in", "Eca", "."], "h": {"id": "C1327841", "name": "C1327841#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0596543", "name": "C0596543#ent", "pos": [18, 19]}}
{"token": ["Exoenzyme", "overproduction", "is", "abolished", "by", "OHL", "deficiency", "a", "HexA-", "and", "Ohll-", "double", "mutant", ",", "indicating", "that", "C1327841#ent", "<e1>", "and", "OHL", "are", "components", "of", "a", "common", "regulatory", "pathway", "C0596543#ent", "<e2>", "production", "."], "h": {"id": "C1327841", "name": "C1327841#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0596543", "name": "C0596543#ent", "pos": [27, 28]}}
{"token": ["Although", ",", "experimentally", ",", "C0162429#ent", "<e1>", "may", "not", "be", "essential", "for", "the", "development", "of", "C0019187#ent", "<e2>", "clinically", ",", "it", "appears", "to", "precede", "the", "development", "of", "the", "liver", "injury", "which", "suggests", "an", "interaction", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019187", "name": "C0019187#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "the", "reciprocal", "response", "of", "C1335272#ent", "<e1>", "versus", "MAG", "genes", "to", "C0003873#ent", "<e2>", "demonstrates", "that", "these", "two", "genes", "utilize", "different", "regulatory", "mechanisms"], "h": {"id": "C1335272", "name": "C1335272#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}}
{"token": ["This", "study", "confirms", "that", "C0919425#ent", "<e1>", "enzyme", "induction", "and", "DNA", "adducts", "C1571454#ent", "<e2>", "useful", "biomarkers", "of", "early", "effects", "induced", "by", "environmental", "exposure", "to", "organochlorines", "."], "h": {"id": "C0919425", "name": "C0919425#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1571454", "name": "C1571454#ent", "pos": [11, 12]}}
{"token": ["The", "data", "of", "this", "study", "provide", "evidence", "that", "the", "mutation", "leading", "to", "T1DM", "in", "the", "LEW.1AR1-iddm", "rat", "is", "located", "at", "the", "telomeric", "end", "C1427656#ent", "<e1>", "corresponding", "to", "C1833218#ent", "<e2>", "."], "h": {"id": "C1427656", "name": "C1427656#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1833218", "name": "C1833218#ent", "pos": [27, 28]}}
{"token": ["Initial", "cleavage", "is", "catalysed", "by", "C0073240#ent", "<e1>", ",", "a", "nuclease", "of", "the", "C1335791#ent", "<e2>", "which", "acts", "on", "primary", "miRNA", "transcripts", "(", "pri-miRNAs", ")", "in", "the", "nucleus", "."], "h": {"id": "C0073240", "name": "C0073240#ent", "pos": [5, 6]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C1335791", "name": "C1335791#ent", "pos": [12, 13]}}
{"token": ["C1456795#ent", "<e1>", "kinase", "binds", "to", "the", "SH3", "domains", "C1333707#ent", "<e2>", ",", "while", "interaction", "of", "the", "p85", "alpha-subunit", "of", "phosphatidylinositol", "3-kinase", "complex"], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333707", "name": "C1333707#ent", "pos": [8, 9]}}
{"token": ["Heme", "oxygenase-2", "C0053602#ent", "<e1>", "immunoreactivity", "was", "present", "in", "all", "C0907533#ent", "<e2>", "containing", "myenteric", "neurons", "."], "h": {"id": "C0053602", "name": "C0053602#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}}
{"token": ["C0033229#ent", "<e1>", "(", "CPZ", ")", "a", "neuroleptic", "which", "has", "both", "C0242889#ent", "<e2>", "and", "antidopaminergic", "activity", "when", "administered", "in", "doses", "of", "5", "to", "25", "mg/kg", "s.c", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [10, 11]}}
{"token": ["This", "provides", "the", "cell", "with", "a", "simple", "and", "efficient", "mechanism", "for", "linking", "C1414314#ent", "<e1>", "changes", "in", "the", "levels", "of", "specific", "C4277588#ent", "<e2>", "other", "signalling", "pathways", "control", "diverse", "processes", "such", "as", "protein", "synthesis", "DNA", "synthesis", "cell", "adhesion"], "h": {"id": "C1414314", "name": "C1414314#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4277588", "name": "C4277588#ent", "pos": [20, 21]}}
{"token": ["Western", "blot", "analysis", "that", "C0879590#ent", "<e1>", "stimulation", "increases", "C0140145#ent", "<e2>"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [8, 9]}}
{"token": ["Our", "previous", "study", "of", "interleukin-2", "(", "C0879590#ent", "<e1>", ")", "signaling", "found", "that", "C0140145#ent", "<e2>", "Ref-1", ")", "mRNA", "was", "upregulated", "by", "C0879590#ent", "<e1>", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [12, 13]}}
{"token": ["Immunoprecipitation", "and", "Western", "blot", "analyses", "that", "IFN-gamma-induced", "phosphorylation", "of", "C1335872#ent", "<e1>", "and", "Jak2", "was", "blocked", "by", "C0079225#ent", "<e2>"], "h": {"id": "C1335872", "name": "C1335872#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079225", "name": "C0079225#ent", "pos": [16, 17]}}
{"token": ["It", "is", "possible", "that", "AA", "type", "C0268381#ent", "<e1>", "may", "be", "of", "importance", "in", "the", "etiology", "of", "C0007785#ent", "<e2>", "the", "young", "adult"], "h": {"id": "C0268381", "name": "C0268381#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [16, 17]}}
{"token": ["Cats", "with", "C0026709#ent", "<e1>", "markedly", "decreased", "C0162298#ent", "<e2>", "and", "strength", "in", "both", "bone", "(", "p", "<", "0.01", ")", "."], "h": {"id": "C0026709", "name": "C0026709#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0162298", "name": "C0162298#ent", "pos": [6, 7]}}
{"token": ["This", "paper", "reports", "on", "a", "case", "of", "C0152116#ent", "<e1>", "longterm", "treatment", "with", "C0040615#ent", "<e2>", "."], "h": {"id": "C0152116", "name": "C0152116#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [12, 13]}}
{"token": ["GABAmimetic", "drugs", ",", "diazepam", ",", "C0037567#ent", "<e1>", "muscimol", "potentiated", "the", "effect", "of", "C0288688#ent", "<e2>", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0288688", "name": "C0288688#ent", "pos": [12, 13]}}
{"token": ["Hippocampal", "pyramidal", "neurons", "in", "culture", "were", "treated", "with", "latrunculin", "A", "to", "depolymerize", "actin", ",", "with", "C0042679#ent", "<e1>", "to", "depolymerize", "microtubules", ",", "or", "with", "C0146951#ent", "<e2>", "extract", "soluble", "proteins", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [23, 24]}}
{"token": ["Peripheral", "blood", "mononuclear", "cells", "stimulated", "by", "phytohemagglutinin", "(", "C0030779#ent", "<e1>", ")", "were", "simultaneously", "phenotyped", "for", "PpIX", ",", "C1420708#ent", "<e2>", "and", "the", "T-cell", "markers", "CD3", "and", "CD4", "or", "CD8", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [17, 18]}}
{"token": ["The", "complexity", "of", "the", "synaptic", "action", "C0110627#ent", "<e1>", "raises", "the", "possibility", "that", "its", "therapeutic", "effects", "C1412122#ent", "<e2>", "poisonings", "are", "not", "limited", "to", "C1412122#ent", "<e2>", "reactivation", "."], "h": {"id": "C0110627", "name": "C0110627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412122", "name": "C1412122#ent", "pos": [15, 16]}}
{"token": ["Budding", "yeast", "C1825023#ent", "<e1>", "is", "required", "for", "kinetochore", "assembly", "and", "its", "C1334043#ent", "<e2>", "have", "a", "role", "in", "cAMP", "signalling", "in", "fungi", "and", "pathogen", "resistance", "plants", "."], "h": {"id": "C1825023", "name": "C1825023#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}}
{"token": ["Transient", "C4055108#ent", "<e1>", "ballooning", "or", "Takotsubo", "cardiomyopathy", "a", "recently", "described", "C0039082#ent", "<e2>", "."], "h": {"id": "C4055108", "name": "C4055108#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [10, 11]}}
{"token": ["Higher", "C1417875#ent", "<e1>", "concentrations", "predict", "Type", "II", "non-insulin-dependent", ")", "diabetes", "mellitus", "it", "is", "not", "known", "whether", "higher", "C1417875#ent", "<e1>", "concentrations", "are", "C1516876#ent", "<e1>", "determined", "or", "reflect", "coexisting", "obesity", "."], "h": {"id": "C1417875", "name": "C1417875#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [21, 22]}}
{"token": ["C0163401#ent", "<e1>", "toxicity", "in", "C2987364#ent", "<e2>", "probably", "due", "to", "inhibition", "or", "binding", "to", "several", "proteins", ",", "only", "one", "of", "which", "is", "AChE."], "h": {"id": "C0163401", "name": "C0163401#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [4, 5]}}
{"token": ["Our", "data", "suggest", "that", "C1161438#ent", "<e1>", "but", "not", "IL-10-induced", "diabetes", "is", "C0015923#ent", "<e2>", "dependent", "."], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015923", "name": "C0015923#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "report", "that", "in", "ADP-activated", "human", "platelets", "cAMP-", "and", "C1336838#ent", "<e1>", "protein-kinase-mediated", "phosphorylation", "of", "the", "focal", "adhesion", "vasodilator-stimulated", "phosphoprotein", "C1421428#ent", "<e2>", ")", "at", "Ser157", "correlates", "well", "with", "glycoprotein", "IIb-IIIa", "inhibition", "."], "h": {"id": "C1336838", "name": "C1336838#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421428", "name": "C1421428#ent", "pos": [20, 21]}}
{"token": ["We", "identified", "C1336838#ent", "<e1>", "Ser239", "and", "Thr278", "phosphorylation", "of", "C1421428#ent", "<e2>", "as", "a", "crucial", "event", "in", "H.", "pylori-dependent", "host", "cell", "elongation", "."], "h": {"id": "C1336838", "name": "C1336838#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421428", "name": "C1421428#ent", "pos": [9, 10]}}
{"token": ["Clinical", "evidence", "the", "effectiveness", "of", "methotrexate", ",", "C0717758#ent", "<e1>", ",", "infliximab", ",", "gold", ",", "hydroxychloroquine", ",", "leflunomide", ",", "C0036078#ent", "<e2>", ",", "penicillamine", ",", "cyclosporin", ",", "azathioprine", "and", "corticosteroids", "."], "h": {"id": "C0717758", "name": "C0717758#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [18, 19]}}
{"token": ["In", "vitro", "resistance", "of", "C1318973#ent", "<e1>", "PMPs", "correlates", "with", "more", "extensive", "disease", "in", "C0014121#ent", "<e2>", "IE", ")", "."], "h": {"id": "C1318973", "name": "C1318973#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [13, 14]}}
{"token": ["Cellulose", "acetate", "gel", "electrophoresis", "fibroblast", "extracts", "the", "patient", "showed", "no", "detectable", "arylsulfatase", "A", "C0022173#ent", "<e1>", "under", "conditions", "that", "clearly", "distinguished", "pseudo-arylsulfatase", "A", "deficiency", "classical", "C3539689#ent", "<e2>", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539689", "name": "C3539689#ent", "pos": [24, 25]}}
{"token": ["By", "genetic", "mapping", "have", "excluded", "ZNF169", "and", "C3468041#ent", "<e1>", "as", "well", "as", "PTCH", "(", "PATCHED", ")", "and", "C1705613#ent", "<e2>", "(", "transforming", "growth", "factor", "beta", "receptor", "type-1)", "genes"], "h": {"id": "C3468041", "name": "C3468041#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705613", "name": "C1705613#ent", "pos": [17, 18]}}
{"token": ["In", "this", "chapter", ",", "the", "system", "to", "study", "the", "cell", "signaling", "pathways", "downstream", "of", "the", "C1428424#ent", "<e1>", "coupling", "to", "G", "proteins", "described", "for", "the", "study", "of", "C0669372#ent", "<e2>", "."], "h": {"id": "C1428424", "name": "C1428424#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [26, 27]}}
{"token": ["Several", "agonists", "acting", "on", "G-protein-coupled", "receptors", "C1428424#ent", "<e1>", ")", "enhance", "the", "mitogenic", "effect", "EGF", "in", "rat", "C0669372#ent", "<e2>", "."], "h": {"id": "C1428424", "name": "C1428424#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}}
{"token": ["Ten", "(", "all", "but", "one", "RD", "with", "C0019559#ent", "<e1>", ")", "had", "increased", "permeability", "to", "C1417453#ent", "<e2>", "after", "oral", "administration", "cow", "milk"], "h": {"id": "C0019559", "name": "C0019559#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417453", "name": "C1417453#ent", "pos": [14, 15]}}
{"token": ["We", "determined", "the", "prevalence", "of", ",", "and", "risk", "factors", ",", "C0015732#ent", "<e1>", "among", "U.S.", "women", "diabetes", "and", "C1708411#ent", "<e2>", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1708411", "name": "C1708411#ent", "pos": [17, 18]}}
{"token": ["Two", "pregnancies", "at", "risk", "for", "the", "C0349653#ent", "<e1>", "CDG1A", ",", "phosphomannomutase", "deficient", ")", "were", "monitored", "by", "C0014442#ent", "<e2>", "and", "genetic", "linkage", "analyses"], "h": {"id": "C0349653", "name": "C0349653#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["An", "abnormal", "transferrin", "isoelectric", "focusing", "pattern", "was", "found", "and", "the", "diagnosis", "of", "C0349653#ent", "<e1>", "confirmed", "by", "C0014442#ent", "<e2>", "and", "molecular", "genetic", "analysis"], "h": {"id": "C0349653", "name": "C0349653#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["The", "results", "demonstrate", "that", "alpha-LA", "induces", "phase", "II", "C3541394#ent", "<e1>", "via", "PI3K-dependent", "C/EBPalpha", "and", "C3540509#ent", "<e2>", "activation", ",", "and", "enhances", "the", "ability", "of", "insulin", "to", "promote", "target", "gene", "induction"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540509", "name": "C3540509#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", "to", "C1412100#ent", "<e1>", ",", "about", "40", "%", "of", "C3540580#ent", "<e2>", "was", "bound", "by", "the", "Millipore", "filter", "Day", "1", ",", "with", "only", "trace", "amounts", "bound", "thereafter", "."], "h": {"id": "C1412100", "name": "C1412100#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540580", "name": "C3540580#ent", "pos": [10, 11]}}
{"token": ["These", "differences", "were", "due", "to", "much", "higher", "secretion", "rate", "of", "C3540580#ent", "<e1>", "than", "C1412100#ent", "<e2>", ",", "resulting", "in", "a", "relatively", "smaller", "fraction", "of", "C3540580#ent", "<e1>", "bound", "to", "the", "filter", "."], "h": {"id": "C1412100", "name": "C1412100#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540580", "name": "C3540580#ent", "pos": [10, 11]}}
{"token": ["C1522575#ent", "<e1>", "mutants", "lacking", "one", "of", "these", "C0010646#ent", "<e2>", "were", "severely", "impaired", "in", "their", "S-linked", "dimerization", ",", "while", "upon", "coexpression", "of", "both", "mutants", "the", "ability", "to", "form", "dimers", "was", "restored", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010646", "name": "C0010646#ent", "pos": [7, 8]}}
{"token": ["The", "C0012634#ent", "<e1>", "Aujeszky's", "disease", "virus", "ADV", ")", ",", "Brucella", ",", "canine", "adenovirus", "C1332670#ent", "<e2>", ")", ",", "canine", "distemper", "virus", "CDV", ")", ",", "canine", "parvovirus", "CPV", ")", ",", "Encephalitozoon", "cuniculi", "Leptospira", ",", "Neospora", "caninum", "and", "Toxoplasma", "gondii"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332670", "name": "C1332670#ent", "pos": [13, 14]}}
{"token": ["Here", "the", "effects", "of", "doses", "of", "a", "specific", "C0162756#ent", "<e1>", "MDL72222", ",", "on", "MDMA", "'s", "ability", "to", "produce", "a", "C1413682#ent", "<e2>", "were", "assessed", "."], "h": {"id": "C0162756", "name": "C0162756#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [19, 20]}}
{"token": ["Cross-linking", "of", "both", "fluid-phase", "and", "adherent", "PMN", "VLA-5", "C4049733#ent", "<e1>", "in", "a", "progressive", "increase", "in", "C1704691#ent", "<e2>", "and", "CD11b/CD18", "expression", "during", "hypoxia", ",", "but", "not", "normoxia", "."], "h": {"id": "C4049733", "name": "C4049733#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704691", "name": "C1704691#ent", "pos": [15, 16]}}
{"token": ["Although", "it", "has", "been", "proposed", "to", "contribute", "to", "the", "control", "of", "cell", "growth", "migration", "through", "association", "with", "the", "Ras", "GTPase-activating", "protein", "the", "C1334864#ent", "<e1>", "the", "role", "of", "C3541333#ent", "<e2>", "remains", "largely", "unknown", "."], "h": {"id": "C1334864", "name": "C1334864#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3541333", "name": "C3541333#ent", "pos": [27, 28]}}
{"token": ["The", "occurrence", "of", "tpr-like", "sequences", "in", "combination", "with", "two", "C0037207#ent", "<e1>", "suggests", "that", "C1420877#ent", "<e2>", "contributes", "a", "domain(s", ")", "relevant", "to", "the", "observed", "activation", "of", "met", "and", "raf", "."], "h": {"id": "C0037207", "name": "C0037207#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420877", "name": "C1420877#ent", "pos": [13, 14]}}
{"token": ["The", "study", "assayed", "cerebrospinal", "fluid", "samples", "from", "585", "subjects", ",", "574", "with", "suspected", "C0025289#ent", "<e1>", "cases", "and", "11", "with", "C0027765#ent", "<e2>"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [19, 20]}}
{"token": ["In", "lesioned", "rats", "driven", "with", "CRF", ",", "C1414571#ent", "<e1>", "resulted", "in", "increases", "in", "C1337111#ent", "<e2>", "mRNA", "and", "plasma", "ACTH", "of", "2.2-", "and", "2.6-fold", ",", "respectively", ",", "compared", "to", "sham", "C1414571#ent", "<e1>", "."], "h": {"id": "C1414571", "name": "C1414571#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [13, 14]}}
{"token": ["In", "adrenalectomized", "(", "C1414571#ent", "<e1>", ")", "animals", ",", "the", "changes", "in", "C1337111#ent", "<e2>", "mRNA", "levels", "were", "not", "significant", "1", "week", "after", "lesion", "in", "the", "IL", "."], "h": {"id": "C1414571", "name": "C1414571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [11, 12]}}
{"token": ["Compared", "with", "control", "tissues", "those", "from", "C1414571#ent", "<e1>", "animals", "had", "significantly", "greater", "contents", "of", "C1337111#ent", "<e2>", ";", "the", "hypothalami", "from", "rats", "with", "experimentally", "induced", "hypercorticalism", "had", "markedly", "reduced", "concentrations", "of", "the", "opioid", "peptide"], "h": {"id": "C1414571", "name": "C1414571#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [14, 15]}}
{"token": ["We", "also", "observed", "decreased", "gene-specific", "DNA", "methylation", "of", "the", "gene", "(", "C1448777#ent", "<e1>", ")", "that", "encodes", "for", "C1332739#ent", "<e2>", ",", "correlating", "with", "increased", "expression", "of", "this", "protein", "."], "h": {"id": "C1448777", "name": "C1448777#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332739", "name": "C1332739#ent", "pos": [17, 18]}}
{"token": ["This", "change", "was", "associated", "with", "increased", "expression", "of", "C1448777#ent", "<e1>", "and", "increased", "levels", "of", "its", "gene", "product", "kinase-associated", "phosphatase", "C1332739#ent", "<e2>", ")", ",", "which", "inhibits", "the", "G(1)/S", "transition", "of", "the", "cell", "cycle", "dephosphorylating", "cyclin-dependent", "kinases"], "h": {"id": "C1448777", "name": "C1448777#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332739", "name": "C1332739#ent", "pos": [19, 20]}}
{"token": ["Based", "on", "the", "deduced", "amino", "acid", "sequences", "all", "these", "C1448777#ent", "<e1>", "classified", "into", "an", "ultrahigh-sulfur", "(", "UHS", ")", "type", "C1332739#ent", "<e2>", "with", "high", "cysteine", "content", "(", ">", "30", "mol%", ")", "."], "h": {"id": "C1448777", "name": "C1448777#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332739", "name": "C1332739#ent", "pos": [19, 20]}}
{"token": ["This", "entity", ",", "with", "its", "unusual", "location", ",", "should", "be", "considered", "in", "the", "differential", "diagnosis", "C0476273#ent", "<e1>", "cyanotic", "spells", ",", "C0043144#ent", "<e2>", ",", "and", "stridor", "in", "infants", "."], "h": {"id": "C0476273", "name": "C0476273#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0043144", "name": "C0043144#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "C0879590#ent", "<e1>", "and", "IL-12", "synergistically", "induced", "C1706474#ent", "<e2>", ",", "whereas", "IFN-alpha", "and", "IL-12", "did", "not", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706474", "name": "C1706474#ent", "pos": [8, 9]}}
{"token": ["Chemical", "and", "functional", "assays", "indicate", "that", "C1412820#ent", "<e1>", "52974", "has", "limited", "ability", "to", "cross", "the", "C1801950#ent", "<e2>", ",", "whereas", "C1412820#ent", "<e1>", "53114", "and", "C1412820#ent", "<e1>", "52656", "can", "freely", "penetrate", "."], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412820", "name": "C1412820#ent", "pos": [6, 7]}}
{"token": ["In", "the", "ovary", ",", "we", "observed", "reduced", "expression", "of", "genes", "encoding", "C1416843#ent", "<e1>", "follistatin", ",", "and", "C0014442#ent", "<e2>", "in", "the", "estradiol", "synthesis", "pathway"], "h": {"id": "C1416843", "name": "C1416843#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["C1366439#ent", "<e1>", "gene", "expression", "human", "testis", "results", "in", "an", "C1366439#ent", "<e1>", "C0597298#ent", "<e1>", "that", "accumulates", "in", "the", "sperm", "head"], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}}
{"token": ["HoxH", "is", "the", "Ni-carrying", "subunit", ",", "and", "together", "with", "C0615748#ent", "<e1>", "it", "forms", "the", "C0020284#ent", "<e2>"], "h": {"id": "C0615748", "name": "C0615748#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020284", "name": "C0020284#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "report", "the", "occurrence", "of", "this", "mutation", "in", "3", "complex", "I-deficient", "patients", "from", "2", "separate", "pedigrees", "who", "presented", "with", "C0023264#ent", "<e1>", "with", "no", "evidence", "or", "family", "history", "Leber's", "hereditary", "optic", "neuropathy", "C0393593#ent", "<e2>", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [21, 22]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [33, 34]}}
{"token": ["However", ",", "in", "other", "situations", "such", "as", "chronic", "renal", "failure", "C0023890#ent", "<e1>", ",", "the", "decreased", "C1522567#ent", "<e2>", "be", "primary", ",", "causing", "decreased", "feedback", "at", "the", "hypothalamic-pituitary", "level", "increased", "GH", "levels", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1522567", "name": "C1522567#ent", "pos": [15, 16]}}
{"token": ["The", "extensive", "vessel", "involvement", "with", "amyloid", "deposition", "the", "absence", "of", "changes", "indicative", "of", "muscular", "dystropyy", "or", "C0751356#ent", "<e1>", "us", "to", "favor", "an", "ischemic", "basis", "for", "this", "C0026848#ent", "<e2>"], "h": {"id": "C0751356", "name": "C0751356#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [26, 27]}}
{"token": ["This", "case", "illustrates", "another", "form", "of", "CIP", ",", "characterized", "by", "an", "C0751356#ent", "<e1>", "which", "is", "histologically", "distinct", "from", "other", "known", "C0026848#ent", "<e2>", "neuropathies", "."], "h": {"id": "C0751356", "name": "C0751356#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [20, 21]}}
{"token": ["C0030779#ent", "<e1>", "accumulation", "in", "the", "strain", "batch", "cultured", "on", "glucose", "under", "C0162429#ent", "<e2>", "90", "%", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [11, 12]}}
{"token": ["Like", "C1423614#ent", "<e1>", ",", "SRP40", "is", "phosphorylated", "by", "C0108555#ent", "<e2>", "but", "to", "a", "much", "lesser", "extent", "."], "h": {"id": "C1423614", "name": "C1423614#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0108555", "name": "C0108555#ent", "pos": [8, 9]}}
{"token": ["PFMCCD", "is", "indeed", "aetiologically", "distinct", "from", "C0008928#ent", "<e1>", ",", "which", "is", "caused", "by", "mutations", "in", "the", "C1419771#ent", "<e2>", "but", "allelic", "with", "isolated", "PFM", ",", "in", "which", "MSX2", "mutations", "were", "previously", "identified", "."], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [6, 7]}, "relation": "disease_has_associated_gene", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [16, 17]}}
{"token": ["Overall", ",", "these", "results", "suggest", "that", "C0008928#ent", "<e1>", "could", "result", "from", "much", "smaller", "losses", "in", "the", "C1419771#ent", "<e2>", "function", "than", "has", "been", "envisioned", "on", "the", "basis", "of", "the", "conventional", "haploinsufficiency", "model"], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [6, 7]}, "relation": "disease_has_associated_gene", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [16, 17]}}
{"token": ["One", "protein", "is", "the", "major", "C1334133#ent", "<e1>", "IRS-1", "and", "the", "second", "is", "the", "SH2", "domain-containing", "oncogenic", "protein", "C1705297#ent", "<e2>", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [17, 18]}}
{"token": ["Two", "of", "the", "C1334133#ent", "<e1>", "substrates", "have", "been", "identified", "as", "IRS-1", "and", "C1705297#ent", "<e2>", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [12, 13]}}
{"token": ["C0068821#ent", "<e1>", "inhibited", "the", "relaxation", "induced", "by", "the", "peptide", "histidine", "isoleucine", "C1333690#ent", "<e2>", ")", ",", "but", "not", "that", "induced", "by", "PACAP", "."], "h": {"id": "C0068821", "name": "C0068821#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [11, 12]}}
{"token": ["C0175778#ent", "<e1>", "and", "HRs", "showed", "no", "significant", "in", "the", "volumes", "of", "C1413044#ent", "<e2>", "and", "dentate", "molecular", "layer", "volume", "or", "the", "number", "of", "dentate", "granule", "cells"], "h": {"id": "C0175778", "name": "C0175778#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413044", "name": "C1413044#ent", "pos": [11, 12]}}
{"token": ["All", "31", "patients", "(", "100", "%", ")", "had", "radiographic", "evidence", "of", "C1112565#ent", "<e1>", "all", "had", "operative", "findings", "C2243080#ent", "<e2>", "20/31", "(", "67", "%", ")", "had", "intestinal", "perforation"], "h": {"id": "C1112565", "name": "C1112565#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2243080", "name": "C2243080#ent", "pos": [17, 18]}}
{"token": ["Surprisingly", ",", "alpha", "6", "beta", "1", "integrin", "subunits", "detected", "in", "the", "same", "cytoplasmic", "structures", "positive", "for", "the", "C1539696#ent", "<e1>", "and", "the", "C1705231#ent", "<e2>", "."], "h": {"id": "C1539696", "name": "C1539696#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705231", "name": "C1705231#ent", "pos": [21, 22]}}
{"token": ["The", "synthetic", "rate", "LDL-apoprotein", "was", "found", "to", "be", "similar", "in", "all", "three", "groups", "(", "C0020557#ent", "<e1>", ",", "normal", "and", "C0020445#ent", "<e2>", ")", "."], "h": {"id": "C0020557", "name": "C0020557#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [19, 20]}}
{"token": ["The", "assay", "readily", "distinguishes", "C1264041#ent", "<e1>", "other", "types", "of", "C0042974#ent", "<e2>", "very", "low", "levels", "of", "vWF", "."], "h": {"id": "C1264041", "name": "C1264041#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0042974", "name": "C0042974#ent", "pos": [9, 10]}}
{"token": ["Since", "we", "failed", "to", "demonstrate", "an", "inhibitor", "in", "the", "plasma", "in", "this", "patient", ",", "the", "etiology", "of", "the", "acquired", "C1264041#ent", "<e1>", "this", "patient", "appears", "to", "differ", "from", "other", "cases", "of", "C0042974#ent", "<e2>"], "h": {"id": "C1264041", "name": "C1264041#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0042974", "name": "C0042974#ent", "pos": [30, 31]}}
{"token": ["These", "included", "55", "cases", "of", "brain", "tumor", "8", "of", "C0014038#ent", "<e1>", ",", "55", "of", "Wernicke", "encephalopathy", "and", "50", "of", "C1843013#ent", "<e2>", "senile", "dementia"], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1843013", "name": "C1843013#ent", "pos": [19, 20]}}
{"token": ["The", "retention", "of", "microsomal", "diacylglycerol", "lipase", "a", "concanavalin", "A-Sepharose", "column", "and", "its", "elution", "by", "C0024748#ent", "<e1>", "the", "glycoprotein", "nature", "of", "this", "C0014442#ent", "<e2>", "."], "h": {"id": "C0024748", "name": "C0024748#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["Liver", "diseases", "associated", "with", "decrease", "in", "hepatic", "drug", "elimination", ",", "but", "there", "is", "evidence", "that", "C0023890#ent", "<e1>", "does", "not", "result", "in", "uniform", "changes", "of", "cytochrome", "P450", "C0796517#ent", "<e2>", ")", "isoenzymes", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0796517", "name": "C0796517#ent", "pos": [26, 27]}}
{"token": ["These", "results", "suggested", "that", "the", "reduction", "of", "nicotine", "metabolism", "in", "C0023890#ent", "<e1>", "was", "due", "to", "decreases", "in", "C0796517#ent", "<e2>", "and", "flavin-containing", "monooxygenase", "protein", "levels", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0796517", "name": "C0796517#ent", "pos": [17, 18]}}
{"token": ["In", "rats", "with", "more", "severe", "C0023890#ent", "<e1>", ",", "the", "content", "of", "all", "four", "C0796517#ent", "<e2>", "isoenzymes", "and", "the", "caffeine", ",", "aminopyrine", ",", "and", "erythromycin", "breath", "tests", "reduced", "whereas", "the", "nitrosodimethylamine", "breath", "test", "unchanged", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0796517", "name": "C0796517#ent", "pos": [13, 14]}}
{"token": ["In", "addition", "L-DOPA", "antagonized", "the", "effect", "of", "C1415169#ent", "<e1>", "on", "acquisition", "of", "CARs", "and", "counteracted", "the", "antagonism", "between", "C1415169#ent", "<e1>", "and", "amphetamine", "in", "acquisition", "of", "CARs", "and", "C4284041#ent", "<e1>", "."], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284041", "name": "C4284041#ent", "pos": [27, 28]}}
{"token": ["Klinefelter's", "syndrome", "be", "associated", "with", "variety", "of", "different", "sex", "chromosome", "anomalies", "C2827598#ent", "<e1>", ",", "XXYY", ",", "XXXY", "and", "C0265499#ent", "<e2>", "."], "h": {"id": "C2827598", "name": "C2827598#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0265499", "name": "C0265499#ent", "pos": [18, 19]}}
{"token": ["A", "detailed", "analysis", "of", "more", "C2827598#ent", "<e1>", "cases", "is", "essential", "to", "clarify", "developmental", "patterns", "learning", "capacity", "individuals", "with", "C0265499#ent", "<e2>"], "h": {"id": "C2827598", "name": "C2827598#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0265499", "name": "C0265499#ent", "pos": [18, 19]}}
{"token": ["This", "work", "suggests", "the", "possibility", "of", "PPAR-alpha", "activators", "as", "novel", "C0003211#ent", "<e1>", "the", "topical", "treatment", "common", "C3875321#ent", "<e2>", "as", "atopic", "dermatitis", "psoriasis", ",", "and", "photodermatitis", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3875321", "name": "C3875321#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "the", "present", "study", "suggests", "that", "this", "catanionic", "bioactive", "formulation", "could", "be", "a", "promising", "dermal", "delivery", "system", "C0003211#ent", "<e1>", "in", "the", "course", "of", "C3875321#ent", "<e2>", "treatment", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3875321", "name": "C3875321#ent", "pos": [24, 25]}}
{"token": ["These", "results", "indicate", "that", "2-DG-induced", "C0020456#ent", "<e1>", "is", "mediated", "by", "alpha", "2-", "and", "C1367657#ent", "<e2>", "amplified", "by", "alpha", "1-adrenoceptor", "blockade"], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [13, 14]}}
{"token": ["In", "vitro", "PrPres", "amplification", "is", "inhibited", "by", "both", "reversible", "and", "irreversible", "C0001645#ent", "<e1>", "indicating", "that", "the", "conformational", "change", "C0074202#ent", "<e2>", "to", "PrPres", "requires", "a", "thiol-containing", "factor", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0074202", "name": "C0074202#ent", "pos": [18, 19]}}
{"token": ["This", "C0027203#ent", "<e1>", "catalyzes", "the", "synthesis", "of", "C3815531#ent", "<e2>", "ALA", ")", ",", "the", "first", "committed", "step", "in", "heme", "synthesis"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3815531", "name": "C3815531#ent", "pos": [7, 8]}}
{"token": ["A", "recently", "described", "mutation", "(", "2936insC", ")", "in", "C2698415#ent", "<e1>", "and", "a", "polymorphism", "in", "C1705581#ent", "<e2>", "896", "A", ">"], "h": {"id": "C2698415", "name": "C2698415#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705581", "name": "C1705581#ent", "pos": [14, 15]}}
{"token": ["The", "allele", "frequencies", "the", "C2698415#ent", "<e1>", "mutation", "and", "the", "C1705581#ent", "<e2>", "896", "G", "variant", "African", "Americans", "similar", "to", "those", "reported", "for", "Caucasians", "."], "h": {"id": "C2698415", "name": "C2698415#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705581", "name": "C1705581#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "examine", "the", "effect", "of", "C0023890#ent", "<e1>", "transplantation", ",", "and", "immunosuppressive", "therapy", "either", "CsA", "or", "tacrolimus", "on", "C0002382#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002382", "name": "C0002382#ent", "pos": [24, 25]}}
{"token": ["More", "recently", ",", "we", "identified", "mammalian", "Sos", ",", "a", "guanine-nucleotide", "exchange", "factor", "C0525678#ent", "<e1>", ",", "as", "an", "C1416520#ent", "<e2>", "SH3", "domain-binding", "partner"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416520", "name": "C1416520#ent", "pos": [17, 18]}}
{"token": ["The", "combination", "of", "certain", "craniofacial", "features", ",", "including", "partial", "alopecia", "and", "the", "presence", "of", "C1866130#ent", "<e1>", "in", "the", "MRI", "are", "suggestive", "of", "C0795959#ent", "<e2>"], "h": {"id": "C1866130", "name": "C1866130#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0795959", "name": "C0795959#ent", "pos": [22, 23]}}
{"token": ["The", "effect", "of", "various", "concentrations", "of", "C1412125#ent", "<e1>", "on", "its", "C1413347#ent", "<e2>", "activity", "resembles", "that", "on", "endogenous", "C1413347#ent", "<e2>", "activity", "of", "macrophages", "."], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413347", "name": "C1413347#ent", "pos": [10, 11]}}
{"token": ["Preferential", "loss", "of", "the", "C0027096#ent", "<e1>", "as", "observed", "in", "patients", "with", "C1135345#ent", "<e2>", "AQM", ")", "or", "cancer", "cachexia", "causes", "generalized", "muscle", "wasting", "muscle", "weakness", "a", "decrease", "in", "muscle", "fibre", "normalized", "to", "cross-sectional", "area"], "h": {"id": "C0027096", "name": "C0027096#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1135345", "name": "C1135345#ent", "pos": [11, 12]}}
{"token": ["Pt(gly-L-met)Cl", "is", "a", "specific", "label", "for", "methionine", "residues", "of", "proteins", "as", "shown", "with", "the", "C0037231#ent", "<e1>", "aggregate", "of", "C0009325#ent", "<e2>", "."], "h": {"id": "C0037231", "name": "C0037231#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [18, 19]}}
{"token": ["Segment", "long-spacing", "collagen", "(", "C0037231#ent", "<e1>", ")", "can", "be", "precipitated", "from", "solutions", "of", "C0009325#ent", "<e2>", "using", "ATP", "as", "the", "inducing", "agent"], "h": {"id": "C0037231", "name": "C0037231#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [13, 14]}}
{"token": ["ras1", "and", "C1336694#ent", "<e1>", "were", "identified", "to", "be", "coding", "for", "two", "different", "C0086376#ent", "<e2>", "with", "high", "identity"], "h": {"id": "C1336694", "name": "C1336694#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["The", "first", "set", "contains", "89", "interactions", "between", "His", "and", "Phe", ",", "Tyr", ",", "C1336694#ent", "<e1>", ",", "or", "Ade", ",", "observed", "in", "X-ray", "structures", "C0086376#ent", "<e2>", "and", "protein-ligand", "complexes", "."], "h": {"id": "C1336694", "name": "C1336694#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [23, 24]}}
{"token": ["Patients", "tended", "to", "release", "less", "C1705075#ent", "<e1>", ",", "and", "inhibition", "of", "C1705075#ent", "<e1>", "release", "was", "more", "marked", "in", "the", "presence", "of", "C0033551#ent", "<e1>", "and", "lipoxygenase", "inhibitors"], "h": {"id": "C1705075", "name": "C1705075#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [21, 22]}}
{"token": ["Mutations", "in", "the", "down-regulated", "in", "adenoma", "(", "C1335836#ent", "<e1>", ")", "gene", "cause", "C0011991#ent", "<e2>", "the", "transport", "characteristics", "of", "human", "C1335836#ent", "<e1>", "have", "not", "been", "studied", "in", "a", "heterologous", "human", "expression", "system"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1335836", "name": "C1335836#ent", "pos": [7, 8]}}
{"token": ["In", "addition", "to", "the", "well-recognized", "risk", "to", "C0035086#ent", "<e1>", "by", "steroids", ",", "calcineurin", "inhibitors", "pre-existing", "C0035086#ent", "<e1>", "persistent", "hyperparathyroidism", "C1384672#ent", "<e1>", ")", "contributes", "to", "post-transplant", "bone", "loss", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1384672", "name": "C1384672#ent", "pos": [19, 20]}}
{"token": ["C0025912#ent", "<e1>", "showed", "no", "significant", "C0242896#ent", "<e2>", "any", "of", "the", "measures", "used", "."], "h": {"id": "C0025912", "name": "C0025912#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [5, 6]}}
{"token": ["Combined", "treatments", "of", "mycophenolate", "mofetil", "MMF", ")", "and", "C0287041#ent", "<e1>", "(", "LSRT", ")", "have", "synergistic", "effects", "various", "C0012634#ent", "<e2>", "their", "hemodynamic", "and", "anti-inflammatory", "effects"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [17, 18]}}
{"token": ["We", "performed", "a", "sural", "nerve", "biopsy", "a", "patient", "with", "C0238052#ent", "<e1>", "CTX", ")", "because", "of", "electrophysiologic", "evidence", "of", "C0031117#ent", "<e2>"], "h": {"id": "C0238052", "name": "C0238052#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [18, 19]}}
{"token": ["Likewise", ",", "T", "cells", "old", "mice", "secreted", "more", "C0879590#ent", "<e1>", "when", "cultured", "with", "C1704947#ent", "<e2>", "young", "mice", "compared", "to", "those", "cultured", "with", "C1704947#ent", "<e2>", "old", "mice"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [13, 14]}}
{"token": ["On", "electron", "microscopy", "thickness", "of", "the", "glomerular", "basement", "membrane", "BGM", ")", "was", "found", "to", "distinguish", "benign", "C0018965#ent", "<e1>", "BFH", "-", "10", "cases", ")", "from", "non", "familial", "idiopathic", "hematuria", "(", "C1704964#ent", "<e2>", "-", "9", "cases", ")", "."], "h": {"id": "C0018965", "name": "C0018965#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704964", "name": "C1704964#ent", "pos": [29, 30]}}
{"token": ["Thus", ",", "we", "diagnosed", "the", "illness", "as", "2,8-DHA", "C0451641#ent", "<e1>", "originating", "from", "C0268120#ent", "<e2>"], "h": {"id": "C0451641", "name": "C0451641#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0268120", "name": "C0268120#ent", "pos": [12, 13]}}
{"token": ["These", "data", "support", "the", "hypothesis", "that", "cortical", "C0001476#ent", "<e1>", "NOS", ",", "primarily", "endothelial", "NOS", "is", "stimulated", "during", "the", "early", "phases", "C0051844#ent", "<e2>", "II-induced", "hypertension", "and", "exerts", "a", "renoprotective", "effect", "on", "cortical", "haemodynamics", "."], "h": {"id": "C0001476", "name": "C0001476#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [20, 21]}}
{"token": ["All", "lymphoid", "tissue", "similar", "levels", "of", "activity", "for", "each", "C0031727#ent", "<e1>", "(", "AK", ",", "dAK", "and", "C0011486#ent", "<e2>", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0011486", "name": "C0011486#ent", "pos": [16, 17]}}
{"token": ["Sometimes", "appearance", "of", "periodic", "oral", "ulcers", "coincides", "with", "periodic", "fever", "other", "symptoms", "leading", "to", "the", "diagnosis", "of", "a", "rare", "childhood", "disease", "PFAPA", "(", "periodic", "fever", "C0585213#ent", "<e1>", "pharyngitis", "and", "C0235522#ent", "<e2>", ")", "syndrome", "."], "h": {"id": "C0585213", "name": "C0585213#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0235522", "name": "C0235522#ent", "pos": [29, 30]}}
{"token": ["The", "second", "patient", "complained", "of", "C0242350#ent", "<e1>", "after", "a", "rash", "while", "taking", "C0031507#ent", "<e2>", "and", "carbamazepine", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "C0287702#ent", "<e1>", "appears", "to", "be", "superior", "to", "C0001644#ent", "<e2>", "PDE", "inhibitors", "as", "a", "cardiotonic", "drug", "the", "treatment", "of", "heart", "failure", "by", "beta-adrenoceptor", "downregulation", "."], "h": {"id": "C0287702", "name": "C0287702#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [9, 10]}}
{"token": ["C4053961#ent", "<e1>", ",", "considered", "a", "rare", "C0752235#ent", "<e2>", "is", "relatively", "uninvestigated", "in", "the", "nursing", "literature"], "h": {"id": "C4053961", "name": "C4053961#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [6, 7]}}
{"token": ["These", "C0086376#ent", "<e1>", "provide", "the", "first", "candidate", "regulators", "of", "C1412356#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412356", "name": "C1412356#ent", "pos": [9, 10]}}
{"token": ["These", "studies", "show", "that", "C0011847#ent", "<e1>", "causes", "an", "increase", "in", "renal", "C1420202#ent", "<e2>", "mRNA", ",", "which", "is", "primarily", "localized", "to", "the", "outer", "medulla"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420202", "name": "C1420202#ent", "pos": [11, 12]}}
{"token": ["After", "seven", "days", "of", "C0011847#ent", "<e1>", ",", "the", "levels", "of", "C1420202#ent", "<e2>", "mRNA", "and", "myo-inositol", "content", "were", "significantly", "increased", "only", "in", "the", "outer", "medulla"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420202", "name": "C1420202#ent", "pos": [10, 11]}}
{"token": ["In", "other", "C0947912#ent", "<e1>", "patients", "(", "10", "cases", ")", "and", "subjects", "with", "C0221775#ent", "<e2>", "10", "cases", ")", "NE", "and", "E", "responses", "exercise", "were", "tested", "."], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221775", "name": "C0221775#ent", "pos": [12, 13]}}
{"token": ["Furthermore", "desferoxamine", "(", "a", "ferric", "chelator", ",", "antioxidants", "or", "C0812281#ent", "<e1>", "scavengers", "(", "catalase", ",", "C0024730#ent", "<e2>", ",", "TEMPOL", "or", "dimethylsulfoxide", ")", "prevented", "NFT", "cytotoxicity", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024730", "name": "C0024730#ent", "pos": [15, 16]}}
{"token": ["We", "measured", "the", "transcapillary", "transfer", "constant", "K", ")", "of", "C0054314#ent", "<e1>", "blood", "flow", "F", ")", "with", "C0063767#ent", "<e2>", "in", "RG-2", "gliomas", "transplanted", "into", "brain", ",", "liver", ",", "kidney", ",", "muscle", ",", "s.c", "."], "h": {"id": "C0054314", "name": "C0054314#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0063767", "name": "C0063767#ent", "pos": [16, 17]}}
{"token": ["Such", "intervention", "strategies", "include", "careful", "administration", "of", "oxygen", "in", "incubators", "through", "monitoring", "of", "blood", "gases", "early", "detection", "C0035344#ent", "<e1>", "utilizing", "the", "international", "evaluation", "of", "C0035344#ent", "<e1>", "diagnosis", ",", "and", "timely", "C1254351#ent", "<e1>", "and", "surgical", "interventions", "premature", "infants"], "h": {"id": "C0035344", "name": "C0035344#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [30, 31]}}
{"token": ["Propranolol", "(", "C0035344#ent", "<e1>", ")", ",", "a", "beta-adrenoreceptor", "blocking", "C1254351#ent", "<e2>", ",", "was", "given", "30", "min", "prior", "to", "preoptic", "injection", "of", "5-ADMP", "."], "h": {"id": "C0035344", "name": "C0035344#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "an", "C0338222#ent", "<e1>", "function", "either", "by", "preventing", "C0243192#ent", "<e2>", "induction", "of", "such", "events", "or", ",", "additionally", ",", "by", "actively", "increasing", "repression", "via", "corepressor", "recruitment", "."], "h": {"id": "C0338222", "name": "C0338222#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [9, 10]}}
{"token": ["Interestingly", ",", "the", "structurally", "related", "retinoids", "C0338222#ent", "<e1>", "9-cis-retinoic", "acid", "display", "slight", "C0243192#ent", "<e2>", "properties", "."], "h": {"id": "C0338222", "name": "C0338222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}}
{"token": ["Sequences", "homologous", "with", "C3889279#ent", "<e1>", "are", "found", "in", "the", "C0017428#ent", "<e2>", "of", "Caenorhabitis", "elegans", "Arabidopsis", "thaliana", "Drosophila", "melanogaster", "and", "a", "homologous", "protein", "been", "reported", "to", "be", "present", "in", "wheat", "eIF3", "."], "h": {"id": "C3889279", "name": "C3889279#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [9, 10]}}
{"token": ["We", "examined", "whether", "C1333721#ent", "<e1>", "interacts", "with", "C1333229#ent", "<e2>", "RPB5", ")", ",", "the", "exposed", "domain", "of", "which", "binds", "transcriptional", "regulatory", "factors", "as", "hepatitis", "B", "virus", "X", "protein", "a", "novel", "regulatory", "protein", "RPB5-mediating", "protein"], "h": {"id": "C1333721", "name": "C1333721#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333229", "name": "C1333229#ent", "pos": [7, 8]}}
{"token": ["In", "the", "period", "where", "activity", "increased", "in", "fed", "animals", "(", "i.e.", ",", "the", "C3813124#ent", "<e1>", "to", "PM", "transition", ")", ",", "a", "portion", "of", "C0058253#ent", "<e2>", "more", "resistant", "to", "thermal", "inactivation"], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0058253", "name": "C0058253#ent", "pos": [23, 24]}}
{"token": ["On", "the", "other", "hand", ",", "C3665349#ent", "<e1>", "induced", "a", "reduction", "in", "oxidative", "markers", "C1743497#ent", "<e2>", "heart", "and", "skeletal", "muscles", "but", "only", "a", "marginal", "change", "in", "lipid", "peroxidation"], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [13, 14]}}
{"token": ["Carp", "homologues", "C1456378#ent", "<e1>", "MAPK", ")", "and", "its", "activator", "MAPK", "kinase", "6", "C1334475#ent", "<e2>", ",", "referred", "to", "as", "MKK6", ")", "were", "identified", "."], "h": {"id": "C1456378", "name": "C1456378#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334475", "name": "C1334475#ent", "pos": [12, 13]}}
{"token": ["C0001477#ent", "<e1>", "the", "basal", "H(2)O(2", ")", "generation", "in", "C1418943#ent", "<e2>", "Cl3", "cells", "at", "a", "level", "corresponding", "to", "20", "%", "of", "the", "leukocyte", "H(2)O(2", ")", "production", "stimulated", "by", "PMA", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [8, 9]}}
{"token": ["In", "alpha-toxin-permeabilized", "preparations", "obtained", "from", "rat", "femoral", "artery", "C0001477#ent", "<e1>", "induced", "a", "tonic", "type", "contraction", "the", "presence", "of", "ATP", "and", "C1418943#ent", "<e2>", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [20, 21]}}
{"token": ["In", "vitro", "transcription-translation", "of", "C1332736#ent", "<e1>", "and", "p30", "cDNAs", "generated", "C0086376#ent", "<e2>", "of", "56", "and", "30", "kDa", ",", "respectively", "."], "h": {"id": "C1332736", "name": "C1332736#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["Further", ",", "glucose", "also", "blocked", "the", "production", "of", "chloramphenicol", "acetyltransferase", "CAT", ")", "C0027203#ent", "<e1>", "induced", "by", "calcitriol", "in", "cells", "transfected", "with", "a", "constructed", "C1706113#ent", "<e2>", "attached", "to", "a", "CAT", "reporter", "gene"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706113", "name": "C1706113#ent", "pos": [23, 24]}}
{"token": ["Intravenous", "phenytoin", ",", "phenobarbital", ",", "and", "C0030438#ent", "<e1>", "are", "effective", "and", "safe", "for", "the", "treatment", "of", "C0036572#ent", "<e2>", "as", "status", "epilepticus"], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [16, 17]}}
{"token": ["In", "five", "of", "the", "10", "children", "(", "50", "%", ")", "who", "received", "C0030438#ent", "<e1>", "and", "phenytoin", "as", "a", "combination", ",", "the", "C0036572#ent", "<e2>", "stopped", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [21, 22]}}
{"token": ["The", "method", "was", "successfully", "applied", "for", "pharmacokinetic", "studies", "C0030438#ent", "<e1>", "in", "children", "with", "C0036572#ent", "<e2>", "associated", "with", "severe", "malaria", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["The", "synthesized", "C0030956#ent", "<e1>", "are", "capable", "of", "enhancing", "PSMA", "C3265462#ent", "<e2>", "enzymatic", "activity", ",", "suggesting", "protein", "folding", "stabilization", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3265462", "name": "C3265462#ent", "pos": [9, 10]}}
{"token": ["Internal", "cleavage", "the", "C0030956#ent", "<e1>", "occurred", "following", "Arg-58", ",", "and", "a", "C3265462#ent", "<e2>", "variably", "removed", "up", "to", "three", "basic", "residues", "from", "the", "newly", "created", "C-terminus", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3265462", "name": "C3265462#ent", "pos": [11, 12]}}
{"token": ["Alternative", "therapies", "uncomplicated", "C0042029#ent", "<e1>", "women", "include", "fluoroquinolones", "and", "C0028156#ent", "<e2>", ",", "but", "the", "activities", "of", "these", "agents", "against", "TMP-SMX-resistant", "isolates", "are", "rarely", "reported", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0028156", "name": "C0028156#ent", "pos": [9, 10]}}
{"token": ["Current", "Israeli", "guidelines", "the", "empiric", "treatment", "uncomplicated", "C0042029#ent", "<e1>", "UTI", ")", "in", "women", "recommend", "C0028156#ent", "<e2>", "for", "5", "days", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0028156", "name": "C0028156#ent", "pos": [14, 15]}}
{"token": ["C2987024#ent", "<e1>", "localized", "to", "16p13", "is", "the", "most", "common", "C0017337#ent", "<e2>", ",", "contributing", "to", "almost", "85", "%", "of", "all", "cases", ",", "is", "associated", "with", "most", "severe", "form", "."], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["Study", "of", "the", "C2987024#ent", "<e1>", "been", "complicated", "because", "most", "of", "the", "C0017337#ent", "<e2>", "lies", "in", "a", "genomic", "region", "elsewhere", "on", "the", "same", "chromosome", "."], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["Transcriptome", "analysis", "a", "rat", "polycystic", "kidney", "disease", "C2987024#ent", "<e1>", ")", "model", ":", "importance", "of", "C0017337#ent", "<e2>", "involved", "in", "extracellular", "matrix", "metabolism"], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["The", "main", "clinical", "manifestations", "C0038012#ent", "<e1>", "and", "sacroiliitis", ",", "but", "C0003864#ent", "<e2>", "involvement", "of", "other", "organ", "systems", "known", "as", "well", "."], "h": {"id": "C0038012", "name": "C0038012#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [10, 11]}}
{"token": ["Twenty-two", "had", "a", "systemic", "illness", "10", "C0003864#ent", "<e1>", ",", "10", "C0038012#ent", "<e2>", ",", "and", "four", "C0003864#ent", "<e1>", "and", "C0038012#ent", "<e2>", "."], "h": {"id": "C0038012", "name": "C0038012#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [6, 7]}}
{"token": ["C3502539#ent", "<e1>", "(", "5", "microM", ")", "blocked", "the", "C2346452#ent", "<e2>", "current", "."], "h": {"id": "C3502539", "name": "C3502539#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2346452", "name": "C2346452#ent", "pos": [8, 9]}}
{"token": ["Importantly", ",", "we", "identified", "six", "lysine", "residues", "in", "the", "C-terminal", "domain", "C1335231#ent", "<e1>", "as", "ubiquitin", "acceptor", "sites", "mediated", "by", "C1538116#ent", "<e2>", "."], "h": {"id": "C1335231", "name": "C1335231#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1538116", "name": "C1538116#ent", "pos": [19, 20]}}
{"token": ["Zinc", "significantly", "increased", "serine-473", "phosphorylation", "of", "C0812228#ent", "<e1>", "in", "both", "C1414069#ent", "<e2>", "and", "adipocytes", "(", "P", "<", "0.05", ")", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414069", "name": "C1414069#ent", "pos": [10, 11]}}
{"token": ["Incubation", "of", "lysed", "red", "blood", "cell", "RBC", ")", "supernatant", "yielded", "a", "significant", "decrease", "in", "C0067385#ent", "<e1>", "that", "was", "blocked", "by", "4124W", ",", "a", "C0033671#ent", "<e2>", "dimethylarginine", "dimethylaminohydrolase", "the", "only", "reported", "enzyme", "to", "hydrolyze", "C0067385#ent", "<e1>", "."], "h": {"id": "C0033671", "name": "C0033671#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0067385", "name": "C0067385#ent", "pos": [14, 15]}}
{"token": ["PNH", "usually", "if", "not", "always", "results", "from", "a", "somatic", "mutation", "of", "an", "X-linked", "gene", "C3272445#ent", "<e1>", ";", "the", "product", "of", "the", "PIG-A", "gene", "a", "C1333828#ent", "<e2>", "for", "construction", "of", "the", "GPI", "anchor"], "h": {"id": "C3272445", "name": "C3272445#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "the", "correlation", "between", "C0011854#ent", "<e1>", "susceptibility", "and", "C1333900#ent", "<e2>", "and", "DQB1", "genes", "in", "Shandong", "Han", "population", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333900", "name": "C1333900#ent", "pos": [9, 10]}}
{"token": ["From", "the", "liver", "biopsy", "was", "found", "that", "45", "patients", "had", "fatty", "liver", "14", "had", "C0023890#ent", "<e1>", "and", "11", "had", "chronic", "inflammation", "3", "had", "C1858664#ent", "<e2>", "and", "10", "had", "unspecific", "changes", "or", "normal", "findings"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C1858664", "name": "C1858664#ent", "pos": [23, 24]}}
{"token": ["Hepatocellular", "carcinoma", "a", "recognized", "complication", "of", "C0023890#ent", "<e1>", "most", "commonly", "associated", "with", "alcohol", "excess", "C1858664#ent", "<e2>", "and", "chronic", "hepatitis", "B", "infection"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C1858664", "name": "C1858664#ent", "pos": [14, 15]}}
{"token": ["We", "describe", "a", "68-year-old", "man", "who", "developed", "a", "maculopapular", "eruption", "7", "days", "following", "orthotopic", "liver", "transplantation", "C0023890#ent", "<e1>", "with", "malignant", "transformation", "to", "C1858664#ent", "<e2>", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C1858664", "name": "C1858664#ent", "pos": [22, 23]}}
{"token": ["Expression", "of", "RhoB", "T19N", "and", "transfection", "of", "C0812235#ent", "<e1>", "siRNA", "impaired", "sorting", "of", "C1334126#ent", "<e2>", "to", "the", "lysosome", "after", "3", "hours", "of", "CXCL8", "stimulation", "and", "impaired", "CXCL8-induced", "C1334126#ent", "<e2>", "degradation", "."], "h": {"id": "C0812235", "name": "C0812235#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334126", "name": "C1334126#ent", "pos": [13, 14]}}
{"token": ["The", "serine/threonine", "kinase", "Raf-1", "downstream", "of", "Ras", "in", "the", "MAPK", "pathway", "to", "C1370600#ent", "<e1>", "activation", "in", "response", "to", "C0026249#ent", "<e2>", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [18, 19]}}
{"token": ["Akt", "phosphorylation", "is", "accompanied", "by", "the", "inactivation", "of", "C1370600#ent", "<e1>", ",", "a", "member", "of", "the", "C0026249#ent", "<e2>", "activated", "protein", "kinase", "(", "MAPK", ")", "family", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [15, 16]}}
{"token": ["A", "59-year-old", "man", "took", "C0025153#ent", "<e1>", "(", "antimalarial", "drug", ",", "total", "dose", "1,000", "mg", ",", "to", "prevent", "C0024530#ent", "<e2>", "before", "and", "during", "traveling", "to", "South", "Africa"], "h": {"id": "C0025153", "name": "C0025153#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "artemether", "plus", "C0025153#ent", "<e1>", "versus", "quinine", "on", "35", "patients", "with", "complicated", "falciparum", "C0024530#ent", "<e2>", "including", "5", "patients", "with", "cerebral", "malaria", "studied", "."], "h": {"id": "C0025153", "name": "C0025153#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [15, 16]}}
{"token": ["The", "magnitude", "of", "decrease", "in", "mean", "blood", "pressure", "induced", "by", "0.03", "mg/kg", "C0286819#ent", "<e1>", "was", "similar", "to", "that", "induced", "by", "0.003", "mg/kg", "C0028066#ent", "<e2>", "."], "h": {"id": "C0286819", "name": "C0286819#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [22, 23]}}
{"token": ["The", "duration", "of", "action", "of", "C0286819#ent", "<e1>", "on", "CBF", "was", "longer", "than", "that", "of", "C0028066#ent", "<e2>", "or", "nisoldipine", "."], "h": {"id": "C0286819", "name": "C0286819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [14, 15]}}
{"token": ["Like", "for", "most", "transmembrane", "proteins", "translation", "of", "G", "protein-coupled", "receptors", "C1367690#ent", "<e1>", ")", "mRNA", "takes", "place", "at", "the", "endoplasmic", "reticulum", "C1414461#ent", "<e2>", ")", "where", "they", "are", "synthesized", ",", "folded", "and", "assembled", "."], "h": {"id": "C1367690", "name": "C1367690#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [20, 21]}}
{"token": ["The", "etiology", "of", "this", "malformation", "is", "not", "clear", ";", "both", "environmental", "(", "C0010823#ent", "<e1>", "and", "genetic", "risk", "factors", "considered", "(", "mutations", "in", "EMX2", ",", "C1334338#ent", "<e2>", "genes", ")", "."], "h": {"id": "C0010823", "name": "C0010823#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334338", "name": "C1334338#ent", "pos": [24, 25]}}
{"token": ["We", "discuss", "the", "problems", "confirming", "C0149678#ent", "<e1>", "responsibility", "in", "C0339901#ent", "<e2>", "the", "pitfalls", "of", "diagnostic", "tests"], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0339901", "name": "C0339901#ent", "pos": [9, 10]}}
{"token": ["C0771752#ent", "<e1>", "is", "a", "nonsedating", "antihistamine", "for", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C0771752", "name": "C0771752#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [9, 10]}}
{"token": ["C1334331#ent", "<e1>", "is", "a", "human", "homolog", "of", "C0913413#ent", "<e2>", "and", "encodes", "a", "mitotic", "kinase", "physiological", "roles", "remain", "to", "be", "elucidated", "."], "h": {"id": "C1334331", "name": "C1334331#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0913413", "name": "C0913413#ent", "pos": [7, 8]}}
{"token": ["C0086376#ent", "<e1>", "that", "bind", "growth", "hormone", "C1708120#ent", "<e2>", ")", "have", "been", "identified", "in", "the", "blood", "of", "many", "mammalian", "and", "avian", "species", ",", "but", "not", "in", "reptilian", "species", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1708120", "name": "C1708120#ent", "pos": [6, 7]}}
{"token": ["In", "summary", ",", "we", "provide", "evidence", "that", "plasma", "of", "dwarf", "mice", "C0086376#ent", "<e1>", "capable", "of", "binding", "GH", "in", "vivo", "probably", "representing", "C1708120#ent", "<e2>", "not", "complexed", "with", "GH", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1708120", "name": "C1708120#ent", "pos": [21, 22]}}
{"token": ["C0001645#ent", "<e1>", "propranolol", "was", "metabolized", "with", "C1861421#ent", "<e2>", "rat", "liver", "fraction"], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1861421", "name": "C1861421#ent", "pos": [6, 7]}}
{"token": ["The", "presentations", "of", "these", "children", "included", "nephrosis", "and", "C0149985#ent", "<e1>", "the", "corymbiform", "and", "palmar", "rash", "C0039128#ent", "<e2>", ",", "and", "subtle", "signs", "of", "late", "congenital", "infection", "an", "otherwise", "asymptomatic", "child", "."], "h": {"id": "C0149985", "name": "C0149985#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [15, 16]}}
{"token": ["Syphilis", "incognito", "is", "a", "subtype", "of", "latent", "syphilis", "early", "or", "late", ")", "characterized", "by", "no", "signs", "symptoms", "of", "primary", "or", "C0149985#ent", "<e1>", "diagnosed", "by", "positive", "serologic", "results", "for", "C0039128#ent", "<e2>", "during", "routine", "screening", "."], "h": {"id": "C0149985", "name": "C0149985#ent", "pos": [20, 21]}, "relation": "has_nichd_parent", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [28, 29]}}
{"token": ["SIADH", "was", "diagnosed", "because", "she", "was", "free", "from", "other", "diseases", "known", "to", "cause", "C0020625#ent", "<e1>", "such", "as", "dehydration", ",", "cardiac", "dysfunction", "liver", "dysfunction", "renal", "dysfunction", "C3665349#ent", "<e2>", ",", "and", "adrenal", "insufficiency"], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [25, 26]}}
{"token": ["We", "evaluated", "the", "causal", "role", "of", "glucocorticoid", "deficiency", "the", "C0020625#ent", "<e1>", "that", "developed", "in", "a", "57-year-old", "Japanese", "man", "with", "C3665349#ent", "<e2>", "following", "the", "performance", "of", "a", "total", "thyroidectomy", "laryngeal", "cancer"], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [19, 20]}}
{"token": ["A", "37-year-old", "woman", "undergoing", "endocrine", "evaluation", "during", "her", "seventh", "pregnancy", "because", "of", "headaches", ",", "weakness", ",", "and", "C0020625#ent", "<e1>", "was", "found", "to", "have", "central", "hypoadrenalism", "C3665349#ent", "<e2>", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [25, 26]}}
{"token": ["C0020625#ent", "<e1>", "is", "a", "common", "complication", "of", "severe", "C3665349#ent", "<e2>", ",", "but", "is", "usually", "readily", "corrected", "by", "administering", "L-thyroxine", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [8, 9]}}
{"token": ["Neural", "and", "humoral", "sympathetic", "effects", "on", "CP", "were", "characterized", "with", "selective", "C2699403#ent", "<e1>", "and", "alpha-2", "adrenoceptor", "antagonists", "prazosin", "and", "C0242546#ent", "<e2>", ",", "respectively", ")", "."], "h": {"id": "C2699403", "name": "C2699403#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242546", "name": "C0242546#ent", "pos": [19, 20]}}
{"token": ["Though", "anti-Yo", "antibodies", "were", "repeatedly", "positive", ",", "the", "clinical", "findings", "polyneuropathy", "were", "rather", "attributed", "to", "a", "suspected", "C0270984#ent", "<e1>", "chemotherapy", "than", "a", "C1836075#ent", "<e2>", "."], "h": {"id": "C0270984", "name": "C0270984#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1836075", "name": "C1836075#ent", "pos": [22, 23]}}
{"token": ["No", "significant", "in", "DHICA-converting", "activity", "or", "C0007407#ent", "<e1>", "found", "between", "C1706553#ent", "<e2>", "(", "b", ")", "and", "C1706553#ent", "<e2>", "(", "l", ")", "cells", "."], "h": {"id": "C0007407", "name": "C0007407#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706553", "name": "C1706553#ent", "pos": [10, 11]}}
{"token": ["In", "a", "prospective", "trial", "patients", "receiving", "a", "combination", "of", "low", "molecular", "weight", "heparin", "and", "C0012291#ent", "<e1>", "(", "LMWH/DHE", ";", "Embolex", "NM", ")", "as", "a", "routine", "C0016018#ent", "<e2>", "observed", "."], "h": {"id": "C0012291", "name": "C0012291#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [25, 26]}}
{"token": ["The", "C0002895#ent", "<e1>", "substantially", "to", "the", "presentation", "of", "C0002871#ent", "<e2>", "in", "certain", "areas", "of", "the", "Arabian", "Peninsula"], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [8, 9]}}
{"token": ["It", "was", "reduced", "by", "C0031849#ent", "<e1>", "(", "100", "nM", ")", "and", "the", "C0242947#ent", "<e2>", "muscarone", "(", "10", "nM-1", "microM", ")", ",", "and", "enhanced", "by", "atropine", "(", "0.1", "-", "100", "nM", ")", "."], "h": {"id": "C0031849", "name": "C0031849#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242947", "name": "C0242947#ent", "pos": [12, 13]}}
{"token": ["C0031849#ent", "<e1>", "and", "the", "C0242947#ent", "<e2>", "oxotremorine", "also", "caused", "significant", "protection", ",", "while", "the", "effects", "of", "nicotine", "could", "be", "completely", "accounted", "for", "by", "hypothermia", "."], "h": {"id": "C0031849", "name": "C0031849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242947", "name": "C0242947#ent", "pos": [4, 5]}}
{"token": ["Our", "results", "show", "that", "C1366582#ent", "<e1>", "perturbs", "cellular", "functions", "deregulating", "C0656342#ent", "<e2>", "translocation", "from", "H.", "pylori", "gastric", "epithelial", "cells"], "h": {"id": "C1366582", "name": "C1366582#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0656342", "name": "C0656342#ent", "pos": [10, 11]}}
{"token": ["The", "phosphorylated", "C1366582#ent", "<e1>", "binds", "and", "activates", "C0656342#ent", "<e2>", "thereby", "induces", "a", "growth", "factor-like", "morphological", "change", "termed", "the", "\"", "hummingbird", "phenotype", "."], "h": {"id": "C1366582", "name": "C1366582#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0656342", "name": "C0656342#ent", "pos": [7, 8]}}
{"token": ["The", "phosphorylated", "C1366582#ent", "<e1>", "specifically", "binds", "C0656342#ent", "<e2>", "activates", "the", "phosphatase", "activity", "and", "thereby", "induces", "morphological", "transformation", "cells", "."], "h": {"id": "C1366582", "name": "C1366582#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0656342", "name": "C0656342#ent", "pos": [6, 7]}}
{"token": ["The", "present", "study", "was", "designed", "to", "investigate", "the", "involvement", "of", "endogenous", "opioid", "systems", "the", "antinociception", "induced", "by", "the", "C0003289#ent", "<e1>", "desipramine", "and", "C0041056#ent", "<e2>", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [18, 19]}, "relation": "therapeutic_class_of", "t": {"id": "C0041056", "name": "C0041056#ent", "pos": [22, 23]}}
{"token": ["CASE-BY-CASE", "PRESCRIPTION", ":", "Twenty-four", "different", "C0003289#ent", "<e1>", "available", "in", "France", ",", "classed", "among", "C0041056#ent", "<e2>", ",", "non-imipramines", "and", "non", "IMAO", ",", "serotonine", "and", "noradrenaline", "reuptake", "inhibitors", "and", "specific", "serotonin", "reuptake", "inhibitors"], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [5, 6]}, "relation": "therapeutic_class_of", "t": {"id": "C0041056", "name": "C0041056#ent", "pos": [13, 14]}}
{"token": ["The", "54-kDa", "band", "was", "shown", "to", "represent", "the", "intact", "C1420214#ent", "<e1>", "expressing", "a", "recombinant", "C1420214#ent", "<e1>", "contained", "C0079068#ent", "<e1>", "and", "FLAG", "epitope", "tags", "at", "the", "N", "and", "C", "termini", ",", "respectively", "."], "h": {"id": "C1420214", "name": "C1420214#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [17, 18]}}
{"token": ["We", "present", "three", "patients", "with", "C0020255#ent", "<e1>", "from", "these", "C0039082#ent", "<e2>", "they", "are", "first", "cases", "to", "be", "successfully", "treated", "by", "ventricular", "drainage", "shunting", "."], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [9, 10]}}
{"token": ["However", ",", "it", "does", "indicate", "that", "disturbances", "of", "myelinization", "or", "the", "C0020255#ent", "<e1>", "content", "are", "not", "probable", "etiologies", "in", "this", "C0039082#ent", "<e2>", "."], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [20, 21]}}
{"token": ["To", "the", "authors", "'", "knowledge", ",", "this", "is", "the", "first", "report", "to", "provide", "evidence", "that", "C0020255#ent", "<e1>", "lead", "to", "C0039082#ent", "<e2>"], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [19, 20]}}
{"token": ["The", "relevance", "of", "platelet-derived", "chemokines", "was", "confirmed", "in", "adhesion", "assays", "activated", "whole", "blood", "where", "C0666173#ent", "<e1>", "and", "to", "a", "lesser", "extent", ",", "antibodies", "to", "C1335206#ent", "<e2>", "and", "NAP-2", "inhibited", "arrest", "of", "CD14-positive", "monocytes", "."], "h": {"id": "C0666173", "name": "C0666173#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335206", "name": "C1335206#ent", "pos": [24, 25]}}
{"token": ["The", "present", "study", "represents", "a", "comparison", "of", "three", "approaches", "to", "transform", "recombinant", "cytochrome", "P-450", "rCYP", ")", "C0014442#ent", "<e1>", "kinetic", "data", "to", "human", "liver", "activity", "C0049506#ent", "<e2>", "(", "MIR", ")", "biotransformation", "as", "a", "model", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0049506", "name": "C0049506#ent", "pos": [24, 25]}}
{"token": ["The", "C1413391#ent", "<e1>", "clustered", "in", "ORFs", "(", "C1412821#ent", "<e2>", "1", "to", "4", ",", "in", "a", "8-kb", "fragment", "of", "DNA", "."], "h": {"id": "C1413391", "name": "C1413391#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [7, 8]}}
{"token": ["Development", "of", "the", "C1417023#ent", "<e1>", "requires", "the", "function", "of", "a", "diverse", "set", "of", "C1417679#ent", "<e2>", "encoding", "transcription", "factors", "signaling", "molecules", "and", "their", "receptors", "."], "h": {"id": "C1417023", "name": "C1417023#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["Nineteen", "of", "29", "patients", "with", "C0393593#ent", "<e1>", "had", "organic", "acidemias", "primarily", "C0268595#ent", "<e2>", "7", "patients", ")", ",", "bilateral", "striatal", "necrosis", "4", "patients", ")", ",", "and", "3-methyl", "glutaconic", "aciduria", "3", "patients", ")", "."], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0268595", "name": "C0268595#ent", "pos": [11, 12]}}
{"token": ["The", "C0011226#ent", "<e1>", "HDV", ")", "genome", "has", "only", "one", "C0079941#ent", "<e2>", "which", "encodes", "the", "viral", "small", "delta", "antigen"], "h": {"id": "C0011226", "name": "C0011226#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [9, 10]}}
{"token": ["It", "is", "concluded", "that", "cambendazole", "may", "have", "significant", "advantages", "over", "both", "C0039832#ent", "<e1>", "and", "mebendazole", "in", "the", "treatment", "of", "C0038463#ent", "<e2>", "."], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [19, 20]}}
{"token": ["After", "the", "clinical", "symptoms", "subsided", ",", "C0039832#ent", "<e1>", "was", "used", "for", "C0038463#ent", "<e2>", "daily", "doses", "2,500", "mg", "for", "six", "days", "initially", "."], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [11, 12]}}
{"token": ["Because", "C0039832#ent", "<e1>", ",", "the", "drug", "of", "choice", "in", "C0038463#ent", "<e2>", ",", "is", "primarily", "excreted", "by", "the", "kidneys", ",", "alternative", "therapy", "a", "mebendazole", "was", "instituted", "."], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [9, 10]}}
{"token": ["A", "C0235290#ent", "<e1>", "mentioned", "by", "four", "patients", "in", "the", "C0771004#ent", "<e2>", "group", ",", "but", "neither", "somnolence", "nor", "sedation", "was", "reported", "with", "C0771004#ent", "<e2>", "."], "h": {"id": "C0235290", "name": "C0235290#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0771004", "name": "C0771004#ent", "pos": [9, 10]}}
{"token": ["Overexpression", "of", "C0907533#ent", "<e1>", "active", "mutants", "of", "H-Ras", ",", "C1705519#ent", "<e2>", ",", "or", "M-Ras", "resulted", "in", "activation", "of", "coexpressed", "Rac-1", "through", "an", "Ly29402-resistant", ",", "PI-3K-independent", "mechanism", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705519", "name": "C1705519#ent", "pos": [9, 10]}}
{"token": ["Both", "black", "and", "white", "populations", "Birmingham", ",", "Alabama", "were", "analyzed", "for", "the", "frequencies", "of", "carbonic", "anhydrase", "II", "CA", "II", ",", "C0022956#ent", "<e1>", "GLO", ")", "and", "esterase", "D", "C0023381#ent", "<e2>", ")", "isoenzymes", "."], "h": {"id": "C0022956", "name": "C0022956#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0023381", "name": "C0023381#ent", "pos": [27, 28]}}
{"token": ["Treatment", "of", "C3714948#ent", "<e1>", ",", "DU145", ",", "and", "LNCaP", "cells", "with", "C0043603#ent", "<e2>", "or", "zoledronate", "significantly", "reduced", "the", "growth", "of", "all", "three", "cell", "lines"], "h": {"id": "C3714948", "name": "C3714948#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0043603", "name": "C0043603#ent", "pos": [11, 12]}}
{"token": ["Our", "previous", "study", "suggested", "that", "C3887685#ent", "<e1>", "CYP2D6", ")", "is", "involved", "in", "the", "metabolism", "of", "C0040805#ent", "<e2>", "and", "its", "active", "metabolite", "m-chlorophenylpiperazine", "(", "m-CPP", ")", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0040805", "name": "C0040805#ent", "pos": [15, 16]}}
{"token": ["Our", "previous", "study", "suggested", "that", "cytochrome", "P4502D6", "C3887685#ent", "<e1>", ")", "is", "involved", "in", "the", "metabolism", "of", "C0040805#ent", "<e2>", "and", "its", "active", "metabolite", "m-chlorophenylpiperazine", "(", "m-CPP", ")", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0040805", "name": "C0040805#ent", "pos": [16, 17]}}
{"token": ["The", "present", "study", "thus", "suggests", "that", "C3887685#ent", "<e1>", "is", "involved", "in", "the", "metabolism", "of", "C0040805#ent", "<e2>", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [6, 7]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0040805", "name": "C0040805#ent", "pos": [14, 15]}}
{"token": ["Microsequencing", "together", "with", "C0108471#ent", "<e1>", "analysis", "of", "tryptic", "peptides", "the", "following", "sequence", "for", "C0388060#ent", "<e2>", "H-Ala-Val-Lys-Leu-Ser-Ser-Asp-Gly-Asn-Tyr-Pro-Phe-Asp-Leu-Ser-Lys-Glu-Asp-Gly", "-Ala-Gln-Pro-Tyr-Phe-Met-Thr-Pro-Arg-Leu-Arg-Phe-Tyr-Pro-Ile", "."], "h": {"id": "C0108471", "name": "C0108471#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0388060", "name": "C0388060#ent", "pos": [13, 14]}}
{"token": ["C1704436#ent", "<e1>", "include", "polyneuropathy", ",", "C0007286#ent", "<e2>", "myalgic", "state", "and", "rarely", "myokymia", "."], "h": {"id": "C1704436", "name": "C1704436#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [5, 6]}}
{"token": ["Enzymes", "with", "no", "clear", "variation", "were", "adenylate", "kinase", "adenosine", "deaminase", "C0031651#ent", "<e1>", ",", "hexokinase", ",", "pyruvate", "kinase", "glyceraldehyde", "3-phosphate", "dehydrogenase", "aldolase", ",", "C1418501#ent", "<e2>", "phosphopyruvate", "hydratase", "enolase", ")", ",", "phosphoglucomutase-3", ",", "and", "superoxide", "dismutase"], "h": {"id": "C0031651", "name": "C0031651#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418501", "name": "C1418501#ent", "pos": [22, 23]}}
{"token": ["These", "findings", "open", "up", "the", "possibility", "of", "using", "insect", "C1413391#ent", "<e1>", "as", "a", "biopesticidal", "C0027203#ent", "<e2>", "."], "h": {"id": "C1413391", "name": "C1413391#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}}
{"token": ["The", "C1413391#ent", "<e1>", "expressed", "as", "an", "active", "C0027203#ent", "<e2>", "at", "a", "low", "level", "in", "Lactococcus", "lactis", "when", "cloned", "in", "the", "same", "transcriptional", "orientation", "as", "the", "gene", "specifying", "the", "replication", "protein", "the", "vector", "pIL253", "."], "h": {"id": "C1413391", "name": "C1413391#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}}
{"token": ["C0030125#ent", "<e1>", "one", "of", "the", "drugs", "most", "commonly", "used", "for", "C0010346#ent", "<e2>", "treatment", ",", "although", "its", "use", "is", "limited", "due", "to", "side", "effects"], "h": {"id": "C0030125", "name": "C0030125#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [10, 11]}}
{"token": ["C0030125#ent", "<e1>", "5-ASA", ")", "is", "an", "active", "ingredient", "therapeutic", "agents", "for", "C0010346#ent", "<e2>", "ulcerative", "colitis"], "h": {"id": "C0030125", "name": "C0030125#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [11, 12]}}
{"token": ["To", "evaluate", "the", "efficacy", "of", "C0030125#ent", "<e1>", "5-ASA", ")", "in", "preventing", "recurrences", "of", "C0010346#ent", "<e2>"], "h": {"id": "C0030125", "name": "C0030125#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [13, 14]}}
{"token": ["When", "crosslinked", "and", "uncrosslinked", "C0011522#ent", "<e1>", "fragmented", "by", "mechanical", "shear", "mixed", "in", "known", "proportions", ",", "C1427198#ent", "<e2>", "exceeded", "Kh", "of", "a", "single-copy", "gene", "by", "15", "%", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1427198", "name": "C1427198#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "contribution", "of", "CYP2C9", "and", "C0960580#ent", "<e1>", "and", "their", "polymorphisms", "to", "the", "variability", "of", "C0010583#ent", "<e2>", "activation", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [13, 14]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [22, 23]}}
{"token": ["Numerous", "other", "factors", "including", "C0268790#ent", "<e1>", "hypoxia", ",", "ketone", "and", "amino", "acid", "abnormalities", "glycosylation", "of", "C0086376#ent", "<e2>", ",", "or", "hormone", "imbalances", "could", "be", "teratogenic", "."], "h": {"id": "C0268790", "name": "C0268790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["A", "panel", "of", "sera", "obtained", "from", "Cameroonian", "individuals", "afflicted", "with", "C0029001#ent", "<e1>", "positively", "responded", "to", "the", "recombinant", "C3809468#ent", "<e2>", "."], "h": {"id": "C0029001", "name": "C0029001#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3809468", "name": "C3809468#ent", "pos": [17, 18]}}
{"token": ["Levels", "of", "MFO", "C3540017#ent", "<e1>", ",", "including", "ethoxyresorufin-O-deethylase", "(", "EROD", ")", ",", "C0000644#ent", "<e2>", "(", "ECOD", ")", ",", "benzo[a]pyrene", "monooxygenase", "BPMO", ")", ",", "and", "cytochrome", "P450", "measured", "during", "this", "time", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000644", "name": "C0000644#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "the", "use", "of", "C0066105#ent", "<e1>", "studied", "with", "regard", "to", "postoperative", "asymptomatic", "C0004659#ent", "<e2>", "and", "urinary", "tract", "infection"], "h": {"id": "C0066105", "name": "C0066105#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0004659", "name": "C0004659#ent", "pos": [13, 14]}}
{"token": ["In", "16", "cases", "the", "diagnosis", "of", "C0034362#ent", "<e1>", "been", "serologically", "confirmed", "by", "complement", "fixation", "test", "C3811819#ent", "<e2>", ")", ",", "the", "estimated", "number", "of", "unknown", "cases", ",", "however", ",", "may", "be", "considerable", "."], "h": {"id": "C0034362", "name": "C0034362#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3811819", "name": "C3811819#ent", "pos": [15, 16]}}
{"token": ["Surprisingly", ",", "higher", "doses", "of", "C0001002#ent", "<e1>", "did", "not", "potentiate", "the", "hepatotoxicity", "of", "C1420622#ent", "<e2>", ",", "but", "may", "have", "decreased", "the", "severity", "of", "this", "toxicity", "."], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420622", "name": "C1420622#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "if", "C0001002#ent", "<e1>", "treatment", "enhances", "the", "bioactivation", "of", "C1420622#ent", "<e2>", ",", "the", "covalent", "binding", "of", "14C-TCEA", "to", "tissue", "proteins", "assessed", "both", "in", "vivo", "in", "vitro"], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420622", "name": "C1420622#ent", "pos": [10, 11]}}
{"token": ["The", "primary", "structure", "endoprotease", "(", "C0253970#ent", "<e1>", ")", "was", "comparable", "to", "that", "of", "human", "C0919550#ent", "<e2>", "and", "contained", "a", "putative", "catalytic", "domain", "a", "Cys-rich", "domain", ",", "and", "a", "transmembrane", "region"], "h": {"id": "C0253970", "name": "C0253970#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [14, 15]}}
{"token": ["In", "the", "area", "of", "parasitic", "diseases", "has", "been", "directed", "especially", "to", "immunodiagnosis", "of", "helminthic", "diseases", "including", "C0018013#ent", "<e1>", ",", "paragonimiasis", ",", "opisthorchiasis", ",", "C0038463#ent", "<e2>", "and", "trichinellosis", "."], "h": {"id": "C0018013", "name": "C0018013#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [23, 24]}}
{"token": ["To", "determine", "the", "dynamics", "of", "gene", "duplication", "loss", "in", "the", "entire", "C1332858#ent", "<e1>", "we", "performed", "a", "comprehensive", "evolutionary", "analysis", "of", "mammalian", "C0534519#ent", "<e2>", "."], "h": {"id": "C1332858", "name": "C1332858#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [21, 22]}}
{"token": ["C1416485#ent", "<e1>", "a", "new", "class", "of", "potent", "C0085826#ent", "<e2>", "have", "been", "used", "in", "the", "treatment", "of", "ACS", "and", "in", "the", "prevention", "of", "complications", "after", "percutaneous", "coronary", "interventions", "PCI", ")", "."], "h": {"id": "C1416485", "name": "C1416485#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085826", "name": "C0085826#ent", "pos": [7, 8]}}
{"token": ["Limitations", "of", "C1416485#ent", "<e1>", "antagonists", "leave", "scope", "for", "development", "of", "alternative", "C0085826#ent", "<e2>"], "h": {"id": "C1416485", "name": "C1416485#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085826", "name": "C0085826#ent", "pos": [11, 12]}}
{"token": ["Both", "C1366488#ent", "<e1>", "CRF", ")", "and", "glucocorticoid", "receptors", "C1705401#ent", "<e2>", ")", "are", "implicated", "in", "the", "psychotic", "symptoms", "psychiatric", "disorders"], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [8, 9]}}
{"token": ["Significant", "increases", "in", "C1366488#ent", "<e1>", ",", "MR", "and", "C1705401#ent", "<e2>", "mRNAs", "were", "observed", "in", "the", "parvocellular", "PVN", "after", "fornix", "transection", "(", "FT", ")", "."], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [8, 9]}}
{"token": ["Coexpression", "of", "C3273688#ent", "<e1>", "with", "canonical", "WNT", "proteins", "in", "a", "2", "-", "5-fold", "activation", "of", "C1419771#ent", "<e2>", "promoter", "activity", "a", "7", "-", "8-fold", "induction", "of", "endogenous", "mRNA", "in", "mouse", "pluripotent", "mesenchymal", "and", "osteoprogenitor", "cells"], "h": {"id": "C3273688", "name": "C3273688#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [15, 16]}}
{"token": ["The", "coding", "region", "the", "C1419255#ent", "<e1>", "hemochromatosis", "patients", "with", "or", "without", "mutations", "in", "the", "C0018995#ent", "<e2>", "HFE", ",", "were", "examined", "and", "found", "to", "be", "normal", "."], "h": {"id": "C1419255", "name": "C1419255#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [14, 15]}}
{"token": ["These", "data", "suggest", "that", "mutations", "in", "C1419255#ent", "<e1>", "are", "not", "commonly", "associated", "with", "C0018995#ent", "<e2>", "."], "h": {"id": "C1419255", "name": "C1419255#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [13, 14]}}
{"token": ["C0032001#ent", "<e1>", "an", "uncommon", "syndrome", "characterised", "by", "sudden", "onset", "C0270697#ent", "<e2>", ",", "meningeal", "signs", "visual", "disturbances", "ophthalmoplegia", "and", "confusion", "."], "h": {"id": "C0032001", "name": "C0032001#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [9, 10]}}
{"token": ["Eleven", "patients", "(", "20.4", "%", ")", "had", "side-effects", ":", "two", "discontinued", "atorvastatin", "due", "to", "side-effects", ";", "two", "patients", "had", "C0015230#ent", "<e1>", ";", "six", "had", "C0231528#ent", "<e2>", "and", "two", "had", "diarrhoea", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [24, 25]}}
{"token": ["The", "acute", "phase", "2", "months", ",", "and", "was", "characterized", "by", "pulmonary", "edema", "C0015230#ent", "<e1>", ",", "eosinophilia", ",", "and", "C0231528#ent", "<e2>", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [18, 19]}}
{"token": ["C0030969#ent", "<e1>", "imprinted", "synthetic", "polymers", "prepared", "using", "a", "combination", "of", "C4283745#ent", "<e2>", "2-sulfoethyl", "methacrylate", "bound", "and", "converted", "atrazine", "and", "other", "6-chlorotriazine", "herbicides", "to", "less", "toxic", "compounds"], "h": {"id": "C0030969", "name": "C0030969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4283745", "name": "C4283745#ent", "pos": [10, 11]}}
{"token": ["We", "present", "three", "patients", "with", "renal", "failure", "total", "parenteral", "nutrition", "C1420583#ent", "<e1>", ")", "who", "developed", "biochemical", "and", "clinical", "findings", "C0020579#ent", "<e2>", "A.", "Improvement", "followed", "deletion", "of", "vitamin", "A", "the", "C1420583#ent", "<e1>", "."], "h": {"id": "C0020579", "name": "C0020579#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420583", "name": "C1420583#ent", "pos": [10, 11]}}
{"token": ["Disabling", "pansclerotic", "morphea", "PM", ")", "of", "childhood", "is", "a", "rare", "and", "C3714552#ent", "<e1>", "variant", "of", "C0036420#ent", "<e2>"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0036420", "name": "C0036420#ent", "pos": [15, 16]}}
{"token": ["This", "suggests", "it", "is", "a", "second", ",", "autosomal", "member", "this", "C1335597#ent", "<e1>", "humans", "and", "may", "play", "a", "role", "in", "the", "C0084913#ent", "<e2>", "which", "is", "of", "central", "importance", "in", "all", "eukaryotes", "."], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0084913", "name": "C0084913#ent", "pos": [20, 21]}}
{"token": ["There", "are", "indications", "that", "C0276926#ent", "<e1>", "lesions", "could", "become", "co-factors", "for", "viral", "infection", "as", "C0019693#ent", "<e2>", "and", "HPV", "."], "h": {"id": "C0276926", "name": "C0276926#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [14, 15]}}
{"token": ["A", "prospective", "cohort", "study", "conducted", "in", "two", "villages", "in", "Zambia", "to", "compare", "the", "efficacy", "of", "praziquantel", "in", "the", "treatment", "of", "C0276926#ent", "<e1>", "people", "with", "and", "without", "concomitant", "infection", "with", "human", "immunodeficiency", "virus", "C0019693#ent", "<e2>", ")", "."], "h": {"id": "C0276926", "name": "C0276926#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [32, 33]}}
{"token": ["Various", "integrin", "antagonist", "C1332838#ent", "<e1>", "including", "antibodies", ",", "cyclic", "peptides", "C2936235#ent", "<e2>", ",", "and", "non-peptides", "have", "been", "clinically", "evaluated", "and", "shown", "to", "successfully", "modulate", "certain", "disease", "processes"], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936235", "name": "C2936235#ent", "pos": [10, 11]}}
{"token": ["Various", "integrin", "antagonist", "C1332838#ent", "<e1>", ",", "including", "antibodies", ",", "cyclic", "peptides", "C2936235#ent", "<e2>", "and", "non-peptides", ",", "have", "been", "clinically", "evaluated", "and", "have", "been", "shown", "to", "successfully", "modulate", "certain", "disease", "processes"], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936235", "name": "C2936235#ent", "pos": [11, 12]}}
{"token": ["On", "the", "contrary", ",", "bivagotomy", ",", "C0004259#ent", "<e1>", "treatment", ",", "as", "well", "as", "C0265101#ent", "<e2>", "potentiate", "the", "bradycardic", "effect", "tabernanthine", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0265101", "name": "C0265101#ent", "pos": [13, 14]}}
{"token": ["In", "these", "animals", "C0004259#ent", "<e1>", "not", "only", "blocked", "the", "restored", "C0265101#ent", "<e2>", "but", "produced", "a", "further", "inhibition", "of", "the", "pressor", "response", "to", "dimethylphenylpiperazinium", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0265101", "name": "C0265101#ent", "pos": [10, 11]}}
{"token": ["Indirect", "tests", "bronchial", "responsiveness", "C0035064#ent", "<e1>", "such", "as", "adenosine", "5'-monophosphate", "AMP", ")", "or", "bradykinin", "might", "be", "more", "specific", "markers", "of", "a", "therapeutic", "responses", "anti-inflammatory", "treatment", "a", "test", "of", "direct", "responsiveness", "to", "C0035064#ent", "<e1>", "such", "as", "C0600370#ent", "<e1>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [35, 36]}}
{"token": ["Inhalation", "of", "nonspecific", "C0035064#ent", "<e1>", "such", "as", "C0600370#ent", "<e2>", "or", "histamine", "leads", "to", "bronchoconstriction", "in", "most", "cases", ",", "and", "in", "some", ",", "the", "bronchoconstriction", "follows", "exposure", "to", "C0035064#ent", "<e1>", "such", "as", "antigen", "or", "occupational", "irritants"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [7, 8]}}
{"token": ["Differential", "levels", "of", "phosphorylation", "appear", "to", "account", "for", "two", "C0597298#ent", "<e1>", "105", "and", "115", "kDa", ")", "of", "C4255178#ent", "<e2>", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4255178", "name": "C4255178#ent", "pos": [17, 18]}}
{"token": ["The", "mutant", "protein", "NF-E2", "complexes", "that", "bound", "to", "DNA", "with", "the", "same", "affinity", "as", "wild-type", "C0534519#ent", "<e1>", "and", "functioned", "normally", "to", "restore", "C1415481#ent", "<e2>", "expression", "in", "a", "p45-deficient", "MEL", "cell", "line"], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415481", "name": "C1415481#ent", "pos": [22, 23]}}
{"token": ["potentiation", "of", "C0282211#ent", "<e1>", "responses", "and", "reversal", "by", "C0006945#ent", "<e2>", "."], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "nitric", "oxide", "vasoactive", "intestinal", "polypeptide", "partly", "contribute", "to", "the", "relaxation", "induced", "by", "C0282211#ent", "<e1>", "in", "the", "mouse", "gastric", "fundus", "with", "C0006945#ent", "<e2>", "."], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [24, 25]}}
{"token": ["TZP", "(", "10", "microM", ")", "added", "to", "the", "relaxant", "effect", "of", "C0282211#ent", "<e1>", "in", "tissues", "precontracted", "with", "C0006945#ent", "<e2>", "."], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [17, 18]}}
{"token": ["Fumarylacetoacetate", "hydrolase", "C2828026#ent", "<e1>", ")", "is", "an", "enzyme", "which", "is", "deficient", "in", "human", "C0268483#ent", "<e2>"], "h": {"id": "C2828026", "name": "C2828026#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268483", "name": "C0268483#ent", "pos": [13, 14]}}
{"token": ["Induction", "of", "DSBs", "precedes", "inhibition", "of", "DNA", "replication", "is", "associated", "with", "rapid", "activation", "of", "ataxia", "telangectasia", "mutated", "ataxia", "telangectasia", "C3711837#ent", "<e1>", ",", "and", "DNA-dependent", "protein", "kinases", "subsequent", "stimulation", "of", "the", "C1456378#ent", "<e2>"], "h": {"id": "C3711837", "name": "C3711837#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [30, 31]}}
{"token": ["injections", "of", "C0074393#ent", "<e1>", ",", "quinpirole", "(", "QNP", ")", "and", "C0073393#ent", "<e2>", "were", "measured", "in", "the", "forced", "swim", "and", "brief", "sucrose", "preference", "tests", "."], "h": {"id": "C0074393", "name": "C0074393#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "C0074393#ent", "<e1>", "on", "the", "steady-state", "plasma", "concentrations", "of", "C0073393#ent", "<e2>", "and", "its", "active", "metabolite", "9-hydroxyrisperidone", "(", "9-OH-risperidone", ")", "was", "studied", "in", "11", "patients", "with", "schizophrenia", "or", "schizoaffective", "disorder"], "h": {"id": "C0074393", "name": "C0074393#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [11, 12]}}
{"token": ["Because", "Intralipid", "infusion", "did", "not", "alter", "C3715113#ent", "<e1>", "composition", "to", "the", "same", "degree", "as", "did", "C0023816#ent", "<e2>", "inhibition", ",", "its", "effects", "on", "C3715113#ent", "<e1>", "apo", "catabolism", "were", "not", "apparent", "."], "h": {"id": "C3715113", "name": "C3715113#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [15, 16]}}
{"token": ["C0595726#ent", "<e1>", "belong", "to", "a", "new", "class", "of", "C0003209#ent", "<e2>", "by", "montelukast", "in", "France", "."], "h": {"id": "C0595726", "name": "C0595726#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003209", "name": "C0003209#ent", "pos": [8, 9]}}
{"token": ["Mutations", "in", "ABC7", ",", "the", "human", "C1334043#ent", "<e1>", "of", "ATM1", ",", "result", "in", "C0002896#ent", "<e2>", "ataxia", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002896", "name": "C0002896#ent", "pos": [13, 14]}}
{"token": ["The", "C1421354#ent", "<e1>", "overexpression", "in", "these", "clinical", "isolates", "the", "antiproliferative", "effects", "C1414406#ent", "<e2>", "."], "h": {"id": "C1421354", "name": "C1421354#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414406", "name": "C1414406#ent", "pos": [11, 12]}}
{"token": ["Nightly", "doses", "of", "C0015620#ent", "<e1>", "or", "ranitidine", "were", "ineffective", "in", "reducing", "C0017168#ent", "<e2>", "during", "daytime", "hours"], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [11, 12]}}
{"token": ["To", "investigate", "the", "effect", "of", "C0015620#ent", "<e1>", "on", "gastroesophageal", "reflux", "GER", ")", "and", "C0017168#ent", "<e2>", "DGER", ")", "and", "to", "explore", "it", "'s", "possible", "mechanisms", "."], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [13, 14]}}
{"token": ["It", "is", "therefore", "suggested", "that", "in", "C0040128#ent", "<e1>", "TBG", "may", "sometimes", "play", "a", "more", "important", "role", "than", "C1421224#ent", "<e2>", "in", "determining", "the", "free", "thyroxine", "fraction.(e"], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421224", "name": "C1421224#ent", "pos": [17, 18]}}
{"token": ["We", "have", "previously", "demonstrated", "that", "exogenous", "C3273837#ent", "<e1>", "induced", "activation", "of", "normal", "human", "T", "cells", "up-regulating", "C1334105#ent", "<e2>", "production", "by", "monocytes", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334105", "name": "C1334105#ent", "pos": [16, 17]}}
{"token": ["More", "importantly", "we", "showed", ",", "for", "the", "first", "time", ",", "that", "C3273837#ent", "<e1>", "exerts", "its", "activating", "effects", "on", "PBMC", "proliferation", "through", "C1334105#ent", "<e2>", "synthesis", "induction", "by", "monocyte/macrophage", "population"], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334105", "name": "C1334105#ent", "pos": [21, 22]}}
{"token": ["Pyruvate", "produced", "in", "glycolysis", "and", "glutaminolysis", "is", "used", "for", "the", "synthesis", "of", "lactate", ",", "C0017789#ent", "<e1>", "and", "fatty", "acids", "releasing", "the", "hydrogen", "produced", "in", "the", "C1414968#ent", "<e2>"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414968", "name": "C1414968#ent", "pos": [25, 26]}}
{"token": ["These", "findings", "suggest", "that", "C1419111#ent", "<e1>", "may", "be", "central", "to", "AD", "pathogenesis", "since", "all", "proteins", "C1516876#ent", "<e2>", "associated", "with", "AD", "can", "now", "be", "linked", "via", "a", "single", "pathway", "to", "C1419111#ent", "<e1>", "."], "h": {"id": "C1419111", "name": "C1419111#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [15, 16]}}
{"token": ["The", "effect", "was", "blocked", "by", "the", "AT1", "antagonist", "C0126174#ent", "<e1>", "and", "by", "C0038838#ent", "<e2>", "tiron", "and", "was", "not", "observed", "in", "mice", "lacking", "the", "gp91phox", "subunit", "of", "NADPH", "oxidase", "in", "wild-type", "mice", "treated", "with", "NADPH", "oxidase", "peptide", "inhibitor", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [12, 13]}}
{"token": ["Its", "C0003308#ent", "<e1>", "been", "compared", "to", "ciclopiroxolamine", "and", "C0144004#ent", "<e2>", ",", "commonly", "used", "in", "onychomycosis", "treatment", "and", "chosen", "because", "of", "their", "very", "different", "chemical", "structures"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0144004", "name": "C0144004#ent", "pos": [8, 9]}}
{"token": ["In", "comparative", "studies", "bifonazole", "was", "significantly", "superior", "to", "placebo", "and", "at", "least", "as", "effective", "as", "alternative", "C0003308#ent", "<e1>", "clotrimazole", ",", "econazole", ",", "miconazole", ",", "oxiconazole", "and", "C0144004#ent", "<e2>", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [16, 17]}, "relation": "therapeutic_class_of", "t": {"id": "C0144004", "name": "C0144004#ent", "pos": [26, 27]}}
{"token": ["Vital", "prognosis", "on", "either", "C0085605#ent", "<e1>", "hematological", "or", "infectious", "complications", "or", "C0268381#ent", "<e2>", "."], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268381", "name": "C0268381#ent", "pos": [11, 12]}}
{"token": ["This", "is", "only", "the", "fourth", "reported", "case", "of", "C0085605#ent", "<e1>", "myeloma-associated", "amyloidosis", "the", "second", "reported", "case", "of", "light", "chain", "myeloma", "C0268381#ent", "<e2>", "resulting", "in", "a", "progressive", "clinical", "course", "C0085605#ent", "<e1>"], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268381", "name": "C0268381#ent", "pos": [20, 21]}}
{"token": ["The", "mu", "C2987634#ent", "<e1>", "produced", "a", "dose-", "and", "time-dependent", "elevation", "in", "C1333522#ent", "<e2>", "latency", "when", "injected", "into", "the", "basolateral", "amygdala"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333522", "name": "C1333522#ent", "pos": [11, 12]}}
{"token": ["The", "C1416713#ent", "<e1>", "human", "herpesvirus-8", "HHV-8", ";", "also", "known", "as", "Kaposi's", "sarcoma-associated", "herpesvirus", "encodes", "a", "C0021699#ent", "<e2>", "elicits", "cellular", "activation", "events", "."], "h": {"id": "C1416713", "name": "C1416713#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [15, 16]}}
{"token": ["The", "C1416713#ent", "<e1>", "a", "unique", "C0021699#ent", "<e2>", "of", "transforming", "T", "lymphocytes", "experimentally", "."], "h": {"id": "C1416713", "name": "C1416713#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [5, 6]}}
{"token": ["The", "islet", "C0014442#ent", "<e1>", "showed", "the", "highest", "C0049700#ent", "<e2>", "activity", "(", "478", "milliunits/mg", ")", "compared", "to", "the", "other", "isozymes", "and", "Fructose", "2,6-Pase", "activity", "(", "39", "milliunits/mg", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0049700", "name": "C0049700#ent", "pos": [7, 8]}}
{"token": ["Afferent", "vagal", "nerve", "impulses", "mediated", "by", "5-hydroxytryptamine", "(", "serotonin", ";", "5-HT", ")", ",", "vasoactive", "intestinal", "peptide", "C1705713#ent", "<e1>", ")", "and", "substance", "P", "the", "major", "C0991617#ent", "<e2>", "of", "secretory", "stimulation"], "h": {"id": "C1705713", "name": "C1705713#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [24, 25]}}
{"token": ["Although", "deoxythymidylate", "can", "not", "be", "provided", "directly", "by", "C0035547#ent", "<e1>", "the", "gene", "encoding", "thymidylate", "synthase", "is", "absent", "from", "the", "C0242965#ent", "<e2>", "of", "a", "large", "number", "of", "nonsymbiotic", "microbes", "."], "h": {"id": "C0035547", "name": "C0035547#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [19, 20]}}
{"token": ["If", "conservative", "means", "fail", "to", "relieve", "the", "C0030193#ent", "<e1>", "symptoms", "of", "a", "C0311337#ent", "<e2>", "surgical", "removal", "produce", "dramatic", "pain", "relief"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0311337", "name": "C0311337#ent", "pos": [12, 13]}}
{"token": ["Significant", "associations", "were", "found", "between", "C0040034#ent", "<e1>", "and", "cardiac", "valves", "thickening", "dysfunction", ",", "epilepsy", ",", "chorea", ",", "C0003864#ent", "<e2>", ",", "livedo", "reticularis", "skin", "ulcerations"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [17, 18]}}
{"token": ["The", "results", "suggest", "that", "both", "thromboxane", "and", "PAF", "are", "involved", "in", "the", "mechanisms", "leading", "to", "C0040034#ent", "<e1>", "in", "this", "experimental", "model", "C0003864#ent", "<e2>", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [21, 22]}}
{"token": ["C0000546#ent", "<e1>", "increased", "whole", "cell", "microsomal", "membrane", "fluidity", "increased", "intracellular", "Ca2", "+", "in", "C1418388#ent", "<e2>", "and", "U937", "cells", "altered", "the", "distribution", "and", "activity", "of", "protein", "kinase", "C", "U937", "cells", "and", "rapidly", "downregulated", "the", "transcription", "of", "U937", "c-myc", "."], "h": {"id": "C0000546", "name": "C0000546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418388", "name": "C1418388#ent", "pos": [13, 14]}}
{"token": ["In", "point", "of", "fact", ",", "C0000546#ent", "<e1>", "selectively", "destroys", "C1418388#ent", "<e2>", "mitochondria", "."], "h": {"id": "C0000546", "name": "C0000546#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418388", "name": "C1418388#ent", "pos": [9, 10]}}
{"token": ["Plasma", "homocysteine", "concentrations", "were", "increased", "not", "only", "in", "C0007273#ent", "<e1>", "lucunar", "stroke", "also", "in", "haemorrhagic", "or", "C0038454#ent", "<e2>"], "h": {"id": "C0007273", "name": "C0007273#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [16, 17]}}
{"token": ["C1710304#ent", "<e1>", "in", "bronchoalveolar", "lavage", "fluid", "BALF", ")", "and", "expression", "of", "C2349086#ent", "<e2>", "in", "lung", "tissue", "determined", "by", "ELISA", "or", "by", "SABC", "immunohistochemistry", "assay", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "EAC", "also", "inhibited", "the", "C1710304#ent", "<e1>", "NF-kappaB-dependent", "reporter", "gene", "expression", "of", "MMP-9", "and", "C2349086#ent", "<e2>", ",", "and", "the", "invasion", "of", "cancer", "cells"], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [15, 16]}}
{"token": ["The", "other", "C0003205#ent", "<e1>", ",", "taurolin", ",", "noxytiolin", ",", "C0032857#ent", "<e2>", "hypochlorite", "were", "all", "ineffective", "."], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0032857", "name": "C0032857#ent", "pos": [9, 10]}}
{"token": ["Valuable", "C0003205#ent", "<e1>", "subgingival", "application", "include", "10", "%", "C0032857#ent", "<e2>", "for", "professional", "use", "0.1", "-", "0.5", "%", "sodium", "hypochlorite", "patient", "self-care", "."], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0032857", "name": "C0032857#ent", "pos": [8, 9]}}
{"token": ["Dyggve-Melchior-Clausen", "syndrome", "C1969646#ent", "<e1>", ")", "is", "a", "rare", "autosomal-recessive", "disorder", "the", "C0079429#ent", "<e2>", "for", "which", "maps", "to", "chromosome", "18q21.1"], "h": {"id": "C1969646", "name": "C1969646#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["The", "data", "confirm", "the", "hypothesis", "that", "SMC", "and", "C1969646#ent", "<e1>", "are", "allelic", "disorders", "identify", "a", "C0079429#ent", "<e2>", "necessary", "for", "normal", "skeletal", "development", "brain", "function"], "h": {"id": "C1969646", "name": "C1969646#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["Our", "data", "suggest", "that", ",", "although", "C0012091#ent", "<e1>", "does", "not", "interfere", "with", "the", "C0014025#ent", "<e2>", "anti-hypertensive", "effect", "C0014025#ent", "<e2>", "interferes", "with", "the", "effect", "C0012091#ent", "<e1>", "has", "on", "leukocyte", "rolling", "endothelial", "P-selectin", "expression", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [6, 7]}}
{"token": ["Diclofenac", "reduced", "rollers", ",", "whereas", "C0014025#ent", "<e1>", ",", "alone", "or", "combined", "with", "C0012091#ent", "<e2>", ",", "had", "no", "significant", "effect", "on", "rollers", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [12, 13]}}
{"token": ["These", "phenotypic", "and", "evolutionary", "results", "provide", "compelling", "evidence", "for", "the", "positive", "selection", "of", "a", "mutation", "encoding", "increased", "C0042749#ent", "<e1>", "potential", "and", "virulence", "in", "the", "C1417835#ent", "<e2>", "sentinel", "bird", "species", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417835", "name": "C1417835#ent", "pos": [24, 25]}}
{"token": ["Patients", "were", "studied", "if", "they", "had", "received", "C0886883#ent", "<e1>", "for", "at", "least", "three", "months", "and", "if", "their", "C0003299#ent", "<e2>", "changed", "from", "C0886883#ent", "<e1>", "to", "valproic", "acid", "October", "1993", "and", "June", "1994", "."], "h": {"id": "C0886883", "name": "C0886883#ent", "pos": [7, 8]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [17, 18]}}
{"token": ["Barbiturates", "and/or", "C0033148#ent", "<e1>", "were", "observed", "to", "induce", "the", "same", "dysmorphic", "features", "C0020209#ent", "<e2>", "."], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020209", "name": "C0020209#ent", "pos": [12, 13]}}
{"token": ["The", "cDNA", "encoding", "rat", "C0164371#ent", "<e1>", "was", "introduced", "into", "rat", "C1417081#ent", "<e2>", "and", "transcribed", "under", "the", "control", "of", "a", "Rous", "sarcoma", "virus", "promoter", "."], "h": {"id": "C0164371", "name": "C0164371#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417081", "name": "C1417081#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "a", "patient", "whose", "evaluation", "for", "C0085580#ent", "<e1>", "in", "a", "C0270697#ent", "<e2>"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [11, 12]}}
{"token": ["C1416171#ent", "<e1>", "encodes", "a", "C1413746#ent", "<e2>", "RBP/J", ")", "that", "is", "required", "for", "canonical", "signaling", "all", "Notch", "receptors"], "h": {"id": "C1416171", "name": "C1416171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413746", "name": "C1413746#ent", "pos": [4, 5]}}
{"token": ["In", "the", "past", "decade", "a", "number", "of", "interesting", "new", "endocrine", "agents", "been", "developed", "such", "as", "new", "(", "pure", ")", "(anti)steroidal", "agents", ",", "C3714649#ent", "<e1>", ",", "aromatase", "inhibitors", "analogs", "of", "peptide", "hormones", "C3653381#ent", "<e2>", "growth", "factor", "antagonists"], "h": {"id": "C3714649", "name": "C3714649#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3653381", "name": "C3653381#ent", "pos": [31, 32]}}
{"token": ["C1704977#ent", "<e1>", "C1428184#ent", "<e2>", ")", "is", "the", "molecular", "target", "coumarin", "anticoagulants", "mutations", "in", "C1428184#ent", "<e2>", "have", "been", "identified", "previously", "in", "individuals", "who", "required", "high", "warfarin", "doses", "."], "h": {"id": "C1704977", "name": "C1704977#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1428184", "name": "C1428184#ent", "pos": [2, 3]}}
{"token": ["Treatment", "of", "C0085315#ent", "<e1>", "CRL", "8131", "plus", "an", "ineffective", "dose", "of", "C0165603#ent", "<e2>", "reduced", "the", "inflammation", "and", "numbers", "of", "Toxoplasma", "gondii", "cysts", "in", "the", "brain", "."], "h": {"id": "C0085315", "name": "C0085315#ent", "pos": [2, 3]}, "relation": "may_be_prevented_by", "t": {"id": "C0165603", "name": "C0165603#ent", "pos": [11, 12]}}
{"token": ["The", "B19", "PV", "is", "known", "to", "be", "associated", "with", "C0029408#ent", "<e1>", "in", "humans", ",", "and", "C0812299#ent", "<e2>", "was", "recovered", "from", "the", "synovial", "cells", "a", "patient", "with", "rheumatoid", "arthritis"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812299", "name": "C0812299#ent", "pos": [15, 16]}}
{"token": ["We", "found", "that", "mutant", "Ras", "blocks", "serum-", "and", "12-O-tetradecanoyl", "phorbol", "13-acetate-induced", "activation", "of", "C0139905#ent", "<e1>", "NIH3T3", "cells", "and", "C0812215#ent", "<e2>", "as", "well", "as", "B-Raf", "PSK", "stimulation", "by", "nerve", "growth", "factor", "NGF", ")", "in", "PC12", "pheochromocytoma", "cells"], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [18, 19]}}
{"token": ["Following", "stimulation", "with", "C0533199#ent", "<e1>", "23+/-7", "%", "and", "16+/-4", "%", "of", "control", "cells", "C1415186#ent", "<e2>", "5", "and", "7", "d", "of", "cultures", ",", "respectively", "."], "h": {"id": "C0533199", "name": "C0533199#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415186", "name": "C1415186#ent", "pos": [13, 14]}}
{"token": ["Using", "selective", "inhibitors", "we", "have", "identified", "that", "C0089795#ent", "<e1>", "PI-PLC", ")", ",", "but", "not", "phosphatidylcholine", "(PC)-phospholipase", "C", "PC-PLC", ")", "nor", "C0031671#ent", "<e2>", "PC-PLD", ")", ",", "was", "required", "for", "LPS-induced", "NO", "production", "."], "h": {"id": "C0089795", "name": "C0089795#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [20, 21]}}
{"token": ["The", "authors", "conclude", "that", "in", "children", ",", "C0012963#ent", "<e1>", "is", "an", "effective", "C0304509#ent", "<e2>", "principally", "by", "stimulating", "beta", "1-receptors", "in", "the", "myocardium", "producing", "a", "predominantly", "chronotropic", "effect", "without", "significant", "changes", "in", "peripheral", "vascular", "resistance"], "h": {"id": "C0012963", "name": "C0012963#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0304509", "name": "C0304509#ent", "pos": [12, 13]}}
{"token": ["Bilateral", "achilles", "tendinitis", "developed", "in", "a", "40-year-old", "man", "following", "treatment", "with", "C0008809#ent", "<e1>", ",", "500", "mg", "twice", "a", "day", ",", "for", "C0033581#ent", "<e2>", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [21, 22]}}
{"token": ["C3887499#ent", "<e1>", "a", "common", "C0022658#ent", "<e2>"], "h": {"id": "C3887499", "name": "C3887499#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [4, 5]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "find", "out", "whether", "this", "genetic", "association", "due", "to", "a", "close", "linkage", "of", "the", "C1420083#ent", "<e1>", "region", "and", "the", "gene", "coding", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C1420083", "name": "C1420083#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [28, 29]}}
{"token": ["The", "prevalence", "rate", "of", "resistant", "E.", "coli", "C0008809#ent", "<e1>", "and", "erythromycin", "in", "the", "samples", "isolated", "from", "chickens", "with", "C0014836#ent", "<e2>", "was", "significantly", "higher", "than", "healthy", "controls"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0014836", "name": "C0014836#ent", "pos": [18, 19]}}
{"token": ["Genetic", "haplotypes", "five", "marker", "loci", "that", "are", "closely", "linked", "to", "the", "DYT1", "gene", "chromosome", "9q", "determined", "in", "10", "Ashkenazi", "Jewish", "patients", "with", "C1969807#ent", "<e1>", "eight", "with", "musician's", "cramp", "two", "with", "C0154676#ent", "<e2>", "."], "h": {"id": "C1969807", "name": "C1969807#ent", "pos": [22, 23]}, "relation": "has_manifestation", "t": {"id": "C0154676", "name": "C0154676#ent", "pos": [30, 31]}}
{"token": ["In", "23", "of", "24", "patients", "with", "urticaria", "factitia", "C0022642#ent", "<e1>", "caused", "a", "marked", "reduction", "of", "wealing", "and", "C0033775#ent", "<e2>", "."], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033775", "name": "C0033775#ent", "pos": [17, 18]}}
{"token": ["To", "test", "this", "hypothesis", ",", "the", "yeast", "estrogen", "screen", "(", "YES", ")", "was", "created", "by", "expressing", "human", "estrogen", "receptor", "C0242957#ent", "<e1>", ")", "and", "two", "estrogen", "response", "elements", "ERE", ")", "linked", "to", "the", "C1421976#ent", "<e2>"], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [32, 33]}}
{"token": ["The", "DDT", "isomers", "and", "metabolites", "that", "bound", "the", "C0242957#ent", "<e1>", "in", "vitro", "triggered", "estrogen", "receptor-mediated", "transcription", "of", "the", "C1421976#ent", "<e2>", "reporter", "gene", "the", "yeast", "systems", "."], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [18, 19]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "determine", "anatomical", "and", "C0812325#ent", "<e1>", "profiles", "in", "patients", "with", "clinically", "significant", "C0271051#ent", "<e2>", "CSMO", ")", "undergoing", "pars", "plana", "vitrectomy", "PPV", ")", "."], "h": {"id": "C0812325", "name": "C0812325#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0271051", "name": "C0271051#ent", "pos": [18, 19]}}
{"token": ["C1173297#ent", "<e1>", "increased", "in", "half", "of", "the", "C0003873#ent", "<e2>", "patients", ",", "whereas", "CrossLaps", "assays", "were", "increased", "only", "occasionally", "."], "h": {"id": "C1173297", "name": "C1173297#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}}
{"token": ["Surprisingly", ",", "the", "autopsy", "revealed", "a", "malignant", "pheochromocytoma", "from", "the", "right", "adrenal", "gland", "massive", "metastases", "the", "lungs", ",", "C0023899#ent", "<e1>", ",", "lymph", "nodes", "systemic", "bones", "and", "also", "disseminated", "intravascular", "coagulation", "C0010927#ent", "<e2>", ")", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [30, 31]}}
{"token": ["In", "mammals", ",", "the", "C3537377#ent", "<e1>", "of", "four", "members", ",", "Endo180", ",", "DEC-205", ",", "C1418626#ent", "<e2>", "the", "mannose", "receptor"], "h": {"id": "C3537377", "name": "C3537377#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418626", "name": "C1418626#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "C0024141#ent", "<e1>", "anticoagulant", "and", "an", "acquired", "C0272375#ent", "<e2>", "nephrotic", "syndrome", "SLE", "are", "to", "be", "considered", "thrombophilic", "mechanisms", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0272375", "name": "C0272375#ent", "pos": [10, 11]}}
{"token": ["The", "C1417679#ent", "<e1>", "coding", "for", "apo(a", ")", "and", "C1367553#ent", "<e2>", "belong", "to", "a", "family", "of", "related", "C1417679#ent", "<e1>", "sharing", "several", "structural", "sequences", "like", "leader", ",", "kringle", ",", "and", "protease", "domains"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [8, 9]}}
{"token": ["Two", "types", "of", "abnormal", "C1417679#ent", "<e1>", "coding", "for", "C1367553#ent", "<e2>", "were", "identified", "in", "these", "patients", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [8, 9]}}
{"token": ["Therapeutic", "upregulation", "C3814791#ent", "<e1>", "expression", "using", "replication", "deficient", "adenoviral", "expression", "vectors", "pharmacological", "interventions", "thyroid", "hormone", "analogues", ",", "C0001644#ent", "<e2>", "and", "novel", "metabolically", "active", "compounds", "are", "currently", "under", "investigation", "for", "the", "treatment", "of", "uncompensated", "cardiac", "hypertrophy", "heart", "failure"], "h": {"id": "C3814791", "name": "C3814791#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [17, 18]}}
{"token": ["The", "introduction", "of", "C0022957#ent", "<e1>", "as", "a", "new", "therapeutic", "agent", "treatment", "of", "C0019151#ent", "<e2>", "a", "major", "breakthrough", "in", "this", "field", "."], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [12, 13]}}
{"token": ["To", "compare", "the", "efficacy", "of", "probiotic", "preparation", "Golden", "Bifid", "and", "C0022957#ent", "<e1>", "on", "rat", "experimental", "model", "minimal", "C0019151#ent", "<e2>", "MHE", ")", "induced", "by", "thioactamide", "(", "TAA", ")", "."], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "sodium", "benzoate", "a", "safe", "and", "effective", "alternative", "to", "C0022957#ent", "<e1>", "in", "the", "treatment", "of", "C0019151#ent", "<e2>"], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [17, 18]}}
{"token": ["Because", "of", "misleading", "presentation", ",", "diagnosis", "of", "C0029408#ent", "<e1>", "patients", "with", "C0342788#ent", "<e2>", "requires", "a", "high", "index", "suspicion", "and", "an", "early", "treatment"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342788", "name": "C0342788#ent", "pos": [11, 12]}}
{"token": ["Side", "effects", "isolated", "limb", "perfusion", "C1337109#ent", "<e1>", ")", "include", "rhabdomyolysis", ",", "C0030554#ent", "<e2>", ",", "or", "nerve", "palsy"], "h": {"id": "C1337109", "name": "C1337109#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030554", "name": "C0030554#ent", "pos": [11, 12]}}
{"token": ["The", "work", "was", "aimed", "to", "investigate", "the", "differential", "expressions", "of", "lipid", "metabolism", "genes", "in", "the", "early", "stage", "C0003850#ent", "<e1>", "in", "the", "C1704299#ent", "<e2>", "apoE(-/-", ")", ")", "mice", "at", "different", "ages", "with", "normal", "chow", "diet"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1704299", "name": "C1704299#ent", "pos": [21, 22]}}
{"token": ["Here", ",", "we", "evaluate", "the", "potential", "role", "of", "caveolae", "membrane", "domains", "in", "the", "pathogenesis", "of", "C0003850#ent", "<e1>", "by", "using", "C1704299#ent", "<e2>", "ApoE-/-", ")", "mice", "as", "a", "model", "system"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704299", "name": "C1704299#ent", "pos": [19, 20]}}
{"token": ["Classical", "galactosaemia", "caused", "by", "deficiency", "of", "C0016953#ent", "<e1>", "GALT", ")", "is", "characterized", "by", "acute", "symptoms", "hepatocellular", "dysfunction", "C0036690#ent", "<e2>", ",", "cataracts", "and", "failure", "to", "thrive", "."], "h": {"id": "C0016953", "name": "C0016953#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [17, 18]}}
{"token": ["Animals", "fed", "soy", "protein", "more", "neutral", "and", "C0038317#ent", "<e1>", "and", "have", "increased", "activity", "of", "hepatic", "HMG", "CoA", "reductase", "C0008396#ent", "<e2>"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008396", "name": "C0008396#ent", "pos": [18, 19]}}
{"token": ["In", "this", "report", ",", "we", "demonstrated", "that", "both", "PLD1", "and", "C1720860#ent", "<e1>", "repressed", "expression", "of", "cyclin-dependent", "kinase", "inhibitor", "C0079471#ent", "<e2>", "an", "additive", "manner"], "h": {"id": "C1720860", "name": "C1720860#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [18, 19]}}
{"token": ["These", "results", "indicate", "that", "C1414444#ent", "<e1>", "prevents", "C1710520#ent", "<e2>", "from", "aggregating", ",", "enhances", "the", "stability", "of", "C1710520#ent", "<e2>", "and", ",", "perhaps", ",", "maintains", "C1710520#ent", "<e2>", "in", "an", "export-competent", "state", "."], "h": {"id": "C1414444", "name": "C1414444#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1710520", "name": "C1710520#ent", "pos": [7, 8]}}
{"token": ["We", "suggest", "that", "C1414444#ent", "<e1>", "functions", "as", "a", "specific", "molecular", "chaperone", "C1710520#ent", "<e2>", ",", "the", "first", "such", "chaperone", "linked", "to", "the", "presumed", "type", "IV", "secretion", "system"], "h": {"id": "C1414444", "name": "C1414444#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1710520", "name": "C1710520#ent", "pos": [11, 12]}}
{"token": ["C1414444#ent", "<e1>", "functions", "as", "a", "chaperone", "of", "C1710520#ent", "<e2>", "by", "regulating", "its", "efficient", "translation", "and", "preventing", "VirE2-VirE2", "aggregation", "in", "the", "bacterial", "cell"], "h": {"id": "C1414444", "name": "C1414444#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1710520", "name": "C1710520#ent", "pos": [7, 8]}}
{"token": ["The", "study", "also", "shows", "that", "C1705010#ent", "<e1>", "has", "a", "protective", "effect", "diffuse", "C0017205#ent", "<e2>", "in", "liver", "and", "atherosclerosis", "in", "hyperlipidaemia", "quails", ",", "and", "that", "C1705010#ent", "<e1>", "can", "lower", "the", "lipoprotein", "levels", "hyperlipidaemia", "animals", "."], "h": {"id": "C1705010", "name": "C1705010#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017205", "name": "C0017205#ent", "pos": [12, 13]}}
{"token": ["administration", "of", "hypertonic", "saline-dextran", "HSD", ")", "solution", "combined", "with", "oral", "administration", "isotonic", "electrolyte", "solution", "for", "resuscitating", "severely", "C0011175#ent", "<e1>", "to", "compare", "the", "resuscitative", "response", "that", "of", "a", "conventional", "treatment", "lactated", "Ringer's", "solution", "C0175778#ent", "<e2>", ")", "i.v", "."], "h": {"id": "C0011175", "name": "C0011175#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0175778", "name": "C0175778#ent", "pos": [32, 33]}}
{"token": ["The", "group", "included", "25", "patients", "with", "no", "apparent", "underlying", "C0242634#ent", "<e1>", "13", "with", "either", "ankylosing", "spondylitis", "inflammatory", "bowel", "disease", "C0085435#ent", "<e2>", "or", "Reiter's", "syndrome"], "h": {"id": "C0242634", "name": "C0242634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085435", "name": "C0085435#ent", "pos": [19, 20]}}
{"token": ["We", "report", "a", "55-year-old", "woman", "with", "adult", "C0221056#ent", "<e1>", "who", "developed", "C0221032#ent", "<e2>", "of", "the", "thighs", ",", "hypertriglyceridemia", ",", "and", "insulin", "resistance"], "h": {"id": "C0221056", "name": "C0221056#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221032", "name": "C0221032#ent", "pos": [11, 12]}}
{"token": ["For", "C0042665#ent", "<e1>", ",", "metapramine", ",", "piribedil", "and", "C0031977#ent", "<e2>", "no", "significant", "dose", "effects", "revealed", "at", "the", "doses", "tested", "."], "h": {"id": "C0042665", "name": "C0042665#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031977", "name": "C0031977#ent", "pos": [8, 9]}}
{"token": ["In", "the", "present", "study", "we", "investigated", "the", "levels", "of", "C1413204#ent", "<e1>", "in", "patients", "with", "C0017205#ent", "<e2>", "an", "inherited", "lysosomal", "storage", "disorder", "by", "hepato-", "and", "splenomegaly", "due", "to", "excessive", "accumulation", "of", "macrophages", "."], "h": {"id": "C1413204", "name": "C1413204#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017205", "name": "C0017205#ent", "pos": [14, 15]}}
{"token": ["C0009003#ent", "<e1>", "p-chlorophenoxyisobutyric", "acid", ",", "the", "major", "metabolite", "of", "C0009002#ent", "<e2>", ",", "a", "drug", "used", "in", "the", "treatment", "of", "hyperlipemia", ",", "was", "assayed", "in", "blood", "serum", "an", "ultraviolet", "absorbance", "monitor", "as", "a", "gas-liquid", "chromatographic", "detector"], "h": {"id": "C0009003", "name": "C0009003#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [9, 10]}}
{"token": ["Overnight", "exposure", "to", "microM", "and", "higher", "concentrations", "of", "C0009003#ent", "<e1>", "concentration-dependent", "increases", "in", "the", "comet", "areas", "hepatocyte", "nuclei", "with", "1", "mM", "C0009002#ent", "<e2>", "producing", "a", "3.6-fold", "elevation", "over", "controls", "."], "h": {"id": "C0009003", "name": "C0009003#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [21, 22]}}
{"token": ["C1417377#ent", "<e1>", "is", "a", "ubiquitously", "expressed", "serine-threonine", "kinase", "C1334043#ent", "<e2>", "to", "the", "budding", "yeast", "Ste20", "whose", "physiological", "regulation", "cellular", "function", "unknown", "."], "h": {"id": "C1417377", "name": "C1417377#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}}
{"token": ["Although", "noninvasive", "positive", "pressure", "ventilation", "NPPV", ")", "improves", "outcomes", "in", "patients", "who", "have", "C1145670#ent", "<e1>", "to", "chronic", "obstructive", "pulmonary", "disease", "COPD", ")", "or", "congestive", "heart", "failure", "C0019099#ent", "<e2>", ")", ",", "it", "may", "be", "underutilized", "outside", "the", "controlled", "trial", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [26, 27]}}
{"token": ["C0019034#ent", "<e1>", "has", "a", "milder", "course", "than", "C0002895#ent", "<e2>"], "h": {"id": "C0019034", "name": "C0019034#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [7, 8]}}
{"token": ["We", "describe", "four", "sickle", "cell", "patients", "(", "two", "with", "C0019034#ent", "<e1>", "two", "with", "C0002895#ent", "<e2>", "who", "developed", "hematologic", "malignancy", "acute", "myeloblastic", "leukemia", "multiple", "myeloma", "malignant", "histiocytosis", "and", "Hodgkin's", "disease", "."], "h": {"id": "C0019034", "name": "C0019034#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [13, 14]}}
{"token": ["New", "compounds", "each", "class", "of", "microtubular", "drugs", ",", "C0246415#ent", "<e1>", ",", "as", "stabilizing", "agent", "and", "CI", "980", ",", "as", "C0009262#ent", "<e2>", "currently", "in", "clinical", "trials", "were", "tested", "at", "high", "and", "low", "concentrations", "."], "h": {"id": "C0246415", "name": "C0246415#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [19, 20]}}
{"token": ["Chorea-acanthocytosis", "is", "also", "an", "autosomal", "recessive", "condition", "and", "is", "characterised", "by", "C0152113#ent", "<e1>", ",", "orofaciolingual", "dyskinesia", ",", "C0011168#ent", "<e2>", ",", "dysarthria", ",", "areflexia", ",", "seizures", "and", "dementia", "."], "h": {"id": "C0152113", "name": "C0152113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [17, 18]}}
{"token": ["We", "show", "here", "that", "budding", "yeast", "peptidyl-tRNA", "hydrolase", "2", "(", "Pth2", ")", ",", "which", "was", "previously", "recognized", "as", "a", "C0051616#ent", "<e1>", "is", "a", "UBL", "C3640998#ent", "<e2>", "participates", "in", "the", "ubiquitin-proteasome", "pathway"], "h": {"id": "C0051616", "name": "C0051616#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3640998", "name": "C3640998#ent", "pos": [24, 25]}}
{"token": ["It", "is", "proposed", "that", "the", "aadA2", "genes", "isolated", "from", "pSa", "and", "from", "R1033", ",", "and", "the", "aadA2", "gene", "from", "C1367472#ent", "<e1>", ",", "be", "designated", "aadA2a", "and", "C1834523#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1834523", "name": "C1834523#ent", "pos": [26, 27]}}
{"token": ["Membrane", "type", "I", "matrix", "metalloproteinase", "MT1-MMP", ")", "and", "the", "diffusible", "matrix", "metalloproteinase", "C1334522#ent", "<e1>", ",", "in", "the", "presence", "of", "the", "tissue", "inhibitor", "C0172537#ent", "<e2>", "constitute", "a", "system", "of", "proteins", "that", "play", "an", "important", "role", "during", "the", "proteolysis", "of", "collagen", "type", "I", "matrices"], "h": {"id": "C1334522", "name": "C1334522#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [22, 23]}}
{"token": ["We", "identified", "mutations", "in", "the", "C1334522#ent", "<e1>", "a", "patient", "with", "Torg", "syndrome", "resulted", "in", "complete", "loss", "of", "C0172537#ent", "<e2>", "activity", "."], "h": {"id": "C1334522", "name": "C1334522#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [17, 18]}}
{"token": ["The", "oxidative", "decarboxylation", "malate", "and", "of", "6-phosphogluconate", "may", "account", "for", "the", "observed", "labelled", "CO2", "formed", "when", "labelled", "glucose", "is", "C0025517#ent", "<e1>", "since", "a", "functional", "tricarboxylic", "acid", "cycle", "doubtful", "in", "this", "C0018889#ent", "<e2>"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [30, 31]}}
{"token": ["To", "study", "the", "consequences", "of", "gradual", "reduction", "of", "the", "C1412854#ent", "<e1>", ",", "inhibition", "of", "C2987246#ent", "<e2>", "expression", "in", "model", "cells", "induced", "using", "short", "hairpin", "RNAs", "shRNAs", ")", "."], "h": {"id": "C1412854", "name": "C1412854#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2987246", "name": "C2987246#ent", "pos": [14, 15]}}
{"token": ["C2984132#ent", "<e1>", "also", "reduced", "C1333891#ent", "<e2>", "HDAC", ")", "activity", "and", "HDAC1", ",", "HDAC2", ",", "and", "HDAC3", "protein", "."], "h": {"id": "C2984132", "name": "C2984132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [4, 5]}}
{"token": ["C2984132#ent", "<e1>", "also", "reduced", "histone", "deacetylase", "HDAC", ")", "activity", "and", "C1333891#ent", "<e2>", ",", "HDAC2", ",", "and", "HDAC3", "protein", "."], "h": {"id": "C2984132", "name": "C2984132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [10, 11]}}
{"token": ["The", "C1704321#ent", "<e1>", "to", "be", "etiologically", "related", "to", "the", "presence", "of", "the", "C0017531#ent", "<e2>"], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017531", "name": "C0017531#ent", "pos": [12, 13]}}
{"token": ["Recently", ",", "we", "reported", "PKA-independent", "activation", "of", "the", "C0010536#ent", "<e1>", "Akt", "as", "well", "co-immunoprecipitation", "of", "Epac1", "with", "C1426113#ent", "<e2>", ",", "p-Akt(Thr-308", ")", ",", "and", "p-Akt(Ser-473", ")", "in", "forskolin-stimulated", "macrophages", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1426113", "name": "C1426113#ent", "pos": [17, 18]}}
{"token": ["In", "a", "C0027947#ent", "<e1>", "mouse", "model", ",", "C0064113#ent", "<e2>", "appeared", "to", "be", "as", "effective", "as", "amphotericin", "B", "Candida", "albicans", "and", "was", "more", "effective", "than", "amphotericin", "B", "treating", "an", "Aspergillus", "infection", "a", "patient", "with", "chronic", "granulomatous", "disease"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [7, 8]}}
{"token": ["This", "study", "analyses", "invasive", "fungal", "infections", "C0027947#ent", "<e1>", "patients", "with", "haematological", "malignancies", "antifungal", "prophylaxis", "C0064113#ent", "<e2>", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "of", "the", "cells", "with", "C0058310#ent", "<e1>", "greatly", "enhanced", "the", "%", "of", "C1366535#ent", "<e2>", "responsive", "cells", "."], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [12, 13]}}
{"token": ["This", "study", "examined", "the", "effect", "of", "gamma", "linolenic", "acid", "C1439334#ent", "<e1>", ")", ",", "an", "anti-cancer", "agent", "on", "C1524023#ent", "<e2>", "induced", "membrane", "ruffling", "the", "human", "cancer", "cell", "line", "HT115", "."], "h": {"id": "C1439334", "name": "C1439334#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [17, 18]}}
{"token": ["Large", "amounts", "of", "d-2-hydroxyglutaric", "acid", "DGA", ")", "accumulate", "in", "d-2-hydroxyglutaric", "aciduria", "D-2-OHGA", ")", ",", "an", "inherited", "C0025517#ent", "<e1>", "by", "severe", "neurological", "dysfunction", "C0235946#ent", "<e2>"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0235946", "name": "C0235946#ent", "pos": [22, 23]}}
{"token": ["Maple", "syrup", "urine", "disease", "MSUD", ")", "is", "an", "inherited", "C0025517#ent", "<e1>", "characterized", "by", "neurological", "dysfunction", "C0235946#ent", "<e2>", "patophysiology", "is", "poorly", "known", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0235946", "name": "C0235946#ent", "pos": [15, 16]}}
{"token": ["Normally", ",", "almost", "all", "50", "C1704810#ent", "<e1>", "introns", "are", "spliced", "at", "or", "adjacent", "to", "the", "C0017337#ent", "<e2>", ",", "before", "mRNA", "transits", "thru", "the", "domain", "."], "h": {"id": "C1704810", "name": "C1704810#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["b", ")", "In", "the", "young", "rat", ",", "C0003927#ent", "<e1>", "not", "be", "inhibited", "by", "C0038317#ent", "<e2>", "and", "appears", "to", "be", "supported", "by", "a", "single", "form", "of", "cytochrome", "P-450"], "h": {"id": "C0003927", "name": "C0003927#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [13, 14]}}
{"token": ["On", "the", "other", "hand", ",", "these", "treatments", "elicited", "differential", "effects", "the", "modulation", "by", "C0040073#ent", "<e1>", "of", "the", "levels", "of", "nerve", "growth", "factor", "C1334112#ent", "<e2>"], "h": {"id": "C0040073", "name": "C0040073#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334112", "name": "C1334112#ent", "pos": [22, 23]}}
{"token": ["During", "an", "infusion", "of", "thiopentone", "to", "control", "status", "C0038220#ent", "<e1>", "secondary", "to", "hypoxic", "brain", "damage", "thiopentone", "and", "C0030883#ent", "<e2>", "levels", "were", "measured", "in", "the", "serum", "and", "cerebrospinal", "fluid", "CSF", ")", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [17, 18]}}
{"token": ["Malarial", "calcineurin", "strongly", "and", "specifically", "inhibited", "by", "C0010592#ent", "<e1>", "CsA", ")", "only", "in", "the", "presence", "of", "C1883559#ent", "<e2>", "P.", "falciparum", "cyclophilin", "but", "not", "a", "mutant", "cyclophilin", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [16, 17]}}
{"token": ["Cotransfection", "experiments", "indicated", "that", "in", "normal", "FRTL-5", "rat", "thyroid", "cells", "C1430988#ent", "<e1>", "promoter", "activity", "increased", "by", "overexpression", "of", "the", "transcription", "factor", "C1367453#ent", "<e2>", "Egr-1", ")", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1367453", "name": "C1367453#ent", "pos": [21, 22]}}
{"token": ["Besides", "C0520679#ent", "<e1>", "the", "history", "included", "a", "small", "atrial", "septal", "defect", "C0003504#ent", "<e2>", "Moyamoya", "disease"], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [11, 12]}}
{"token": ["We", "propose", "use", "of", "C0012544#ent", "<e1>", ",", "such", "as", "C0102118#ent", "<e2>", ",", "to", "decrease", "the", "biochemical", "markers", "bone", "turnover"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0102118", "name": "C0102118#ent", "pos": [9, 10]}}
{"token": ["C0012544#ent", "<e1>", ",", "particularly", "the", "aminobisphosphonates", "risedronate", "and", "C0102118#ent", "<e2>", ",", "have", "been", "shown", "to", "protect", "patients", "on", "GCs", "from", "(", "further", ")", "bone", "loss", "reduce", "vertebral", "fracture", "risk", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0102118", "name": "C0102118#ent", "pos": [8, 9]}}
{"token": ["Various", "C0012544#ent", "<e1>", ",", "such", "as", "C0102118#ent", "<e2>", ",", "clodronate", ",", "etidronate", ",", "ibandronate", ",", "pamidronate", ",", "and", "tiludronate", ",", "have", "been", "investigated", "in", "osteoporosis", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [1, 2]}, "relation": "structural_class_of", "t": {"id": "C0102118", "name": "C0102118#ent", "pos": [6, 7]}}
{"token": ["N-beta-(4-Hydroxyphenethyl)-VDS", ",", "envisaged", "as", "a", "substrate", "for", "the", "enzyme", "tryosinase", ",", "was", "shown", "to", "be", "more", "active", "than", "C0036916#ent", "<e1>", "against", "the", "B16", "melanoma", "has", "only", "marginal", "activity", "the", "C0017796#ent", "<e2>", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017796", "name": "C0017796#ent", "pos": [29, 30]}}
{"token": ["N-Alkylvindesines", "have", "reduced", "activity", "compared", "to", "that", "of", "C0036916#ent", "<e1>", "against", "the", "Gardner", "lymphosarcoma", "C0017796#ent", "<e2>", ")", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017796", "name": "C0017796#ent", "pos": [14, 15]}}
{"token": ["C1415375#ent", "<e1>", "was", "initially", "isolated", "by", "thin-layer", "chromatography", "TLC", ")", ",", "the", "C0031716#ent", "<e2>", "hydrolyzed", ",", "and", "the", "resultant", "diradylglycerol", "was", "derivatized", "with", "7-[(chlorocarbonyl)-methoxy]-4-methylcoumarin", "(", "CMMC", ")", "."], "h": {"id": "C1415375", "name": "C1415375#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031716", "name": "C0031716#ent", "pos": [12, 13]}}
{"token": ["This", "case", "should", "focus", "attention", "on", "the", "association", "of", "primary", "sclerosing", "cholangitis", "C0021051#ent", "<e1>", "particularly", "in", "children", "with", "C0021053#ent", "<e2>", "unexplained", "hepatic", "abnormalities"], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [18, 19]}}
{"token": ["Therefore", ",", "in", "C0162429#ent", "<e1>", "children", "with", "C0024523#ent", "<e2>", "impaired", "function", "of", "the", "hormonal", "entero-insular", "axis", "is", "likely", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [7, 8]}}
{"token": ["The", "diagnosis", "of", "chronic", "idiopathic", "intestinal", "pseudo-obstruction", "been", "established", "in", "this", "patient", "who", "had", "C0162429#ent", "<e1>", "and", "extreme", "weight", "loss", "a", "result", "of", "severe", "C0024523#ent", "<e2>"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [24, 25]}}
{"token": ["C0027697#ent", "<e1>", "may", "occur", ",", "typically", "a", "C0017658#ent", "<e2>", "with", "IgA", "mesangial", "deposits", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [7, 8]}}
{"token": ["The", "neomycin-resistance", "1", "gene", "NEO1", ")", "encodes", "a", "potential", "1151", "as", "integral", "membrane", "protein", "most", "C1334043#ent", "<e1>", "to", "the", "yeast", "DRS2", "gene", "product", ",", "a", "C0001477#ent", "<e2>", "involved", "in", "cytoplasmic", "ribosome", "assembly"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [25, 26]}}
{"token": ["The", "Ca(2+)-binding", "site", "consists", "of", "a", "novel", "C-terminally", "localized", "acidic", "32-amino", "acid", "domain", "also", "present", "in", "the", "C1334043#ent", "<e1>", "beta-synuclein", ",", "as", "shown", "by", "C0001477#ent", "<e2>", "to", "truncated", "recombinant", "and", "synthetic", "alpha-synuclein", "peptides"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [24, 25]}}
{"token": ["We", "describe", "the", "features", "of", "intestinal", "strongyloidiasis", "six", "patients", ";", "five", "of", "them", "were", "immunosuppressed", "(", "four", "on", "C3540725#ent", "<e1>", ",", "one", "with", "C0022661#ent", "<e2>", "."], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "mutations", "that", "typically", "inactivate", "Gsalpha", "also", "impair", "XLalphas", "activity", ",", "consistent", "with", "possible", "role", "for", "XLalphas", "deficiency", "in", "C0029896#ent", "<e1>", "caused", "by", "paternal", "C1366550#ent", "<e2>", "mutations", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1366550", "name": "C1366550#ent", "pos": [25, 26]}}
{"token": ["C1565860#ent", "<e1>", "(", "COX", ")", "as", "well", "as", "Polo-like", "kinases", "C1335227#ent", "<e2>", ")", "are", "involved", "in", "proliferation", "and", "cell", "cycle", "regulation", "have", "been", "suggested", "for", "preventive", "and", "therapeutic", "approaches", "prostate", "carcinoma"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [10, 11]}}
{"token": ["The", "C4049728#ent", "<e1>", "cloned", "from", "representative", "strains", "assigned", "to", "complexes", "I", "C3273406#ent", "<e2>", ",", "and", "the", "Mac", "proteins", "purified", "to", "apparent", "homogeneity", "."], "h": {"id": "C4049728", "name": "C4049728#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [11, 12]}}
{"token": ["Macrophage", "migration", "inhibitory", "factor", "C3538735#ent", "<e1>", ")", "is", "a", "proinflammatory", "cytokine", "important", "in", "animal", "models", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C3538735", "name": "C3538735#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [15, 16]}}
{"token": ["In", "a", "prospective", ",", "randomized", "multicentre", "trial", "efficacy", "and", "safety", "of", "the", "low", "molecular", "weight", "heparin", "C3536766#ent", "<e1>", ")", "fraction", "Fraxiparin", "and", "unfractionated", "C0054452#ent", "<e2>", "Calciparin", ")", "were", "compared", "for", "the", "prevention", "of", "postoperative", "deep", "vein", "thrombosis"], "h": {"id": "C3536766", "name": "C3536766#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0054452", "name": "C0054452#ent", "pos": [23, 24]}}
{"token": ["In", "many", "instances", ",", "C3536766#ent", "<e1>", "LMWH", ")", "have", "replaced", "unfractionated", "C0054452#ent", "<e2>", "for", "prevention", "and", "treatment", "of", "venous", "thromboembolism"], "h": {"id": "C3536766", "name": "C3536766#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054452", "name": "C0054452#ent", "pos": [11, 12]}}
{"token": ["In", "many", "instances", ",", "low", "molecular", "weight", "heparins", "C3536766#ent", "<e1>", ")", "have", "replaced", "unfractionated", "C0054452#ent", "<e2>", "for", "prevention", "and", "treatment", "of", "venous", "thromboembolism"], "h": {"id": "C3536766", "name": "C3536766#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0054452", "name": "C0054452#ent", "pos": [14, 15]}}
{"token": ["Deficiency", "of", "this", "C0027203#ent", "<e1>", ",", "like", "other", "forms", "of", "congenital", "adrenal", "hyperplasia", "C0520463#ent", "<e2>", ")", "can", "be", "difficult", "to", "characterise", "in", "the", "neonatal", "period", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0520463", "name": "C0520463#ent", "pos": [13, 14]}}
{"token": ["However", ",", "activated", "NF-kappaB", "levels", "were", "reduced", "by", "a", "guanylate", "cyclase", "inhibitor", "the", "C0282625#ent", "<e1>", "PP1", ",", "or", "the", "C0138837#ent", "<e2>", "manumycin", "and", "farnesyl", "transferase", "Ftase", ")", "inhibitor", "1", "."], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [19, 20]}}
{"token": ["These", "results", "indicate", "that", "the", "ligand", "stimulation", "of", "some", "G(i)-coupled", "receptors", "triggers", "C1420175#ent", "<e1>", "translocation", "that", "occurs", "independently", "of", "p85/p110alpha-type", "and", "C1705325#ent", "<e2>", "PI-3Ks", "but", "might", "involve", "the", "activation", "of", "Akt", "kinase"], "h": {"id": "C1420175", "name": "C1420175#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705325", "name": "C1705325#ent", "pos": [21, 22]}}
{"token": ["We", "describe", "a", "male", "infant", "presenting", "with", "facial", "dysmorphisms", "those", "of", "C0265219#ent", "<e1>", "neuromotor", "delay", "and", "drug", "-", "resistant", "C3887898#ent", "<e2>"], "h": {"id": "C0265219", "name": "C0265219#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C3887898", "name": "C3887898#ent", "pos": [19, 20]}}
{"token": ["Structural", "alteration", "the", "v-Src", "SH2", "SH3", "domains", "mutants", "that", "could", "not", "interact", "with", "C3274610#ent", "<e1>", "nor", "augment", "the", "transcriptional", "properties", "of", "C0808901#ent", "<e2>", "."], "h": {"id": "C3274610", "name": "C3274610#ent", "pos": [13, 14]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [21, 22]}}
{"token": ["In", "one", "variant", "patient", ",", "the", "C3274610#ent", "<e1>", "fusion", "transcript", "contained", "an", "in-frame", "junction", "of", "exon", "9", "C0808901#ent", "<e2>", "to", "exon", "8", "WT1", "."], "h": {"id": "C3274610", "name": "C3274610#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [17, 18]}}
{"token": ["C1332371#ent", "<e1>", "is", "a", "cochaperone", "for", "the", "heat-shock", "protein", "C1415760#ent", "<e2>", "that", "interacts", "with", "C-Raf", ",", "B-Raf", ",", "Akt", ",", "Bcl-2", ",", "steroid", "hormone", "receptors", "other", "proteins", "."], "h": {"id": "C1332371", "name": "C1332371#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [9, 10]}}
{"token": ["In", "this", "activity", "C1415760#ent", "<e1>", "is", "accompanied", "by", "two", "proteins", ",", "Hdj1", "and", "C1332371#ent", "<e2>", ",", "that", "enable", "C1415760#ent", "<e1>", "to", "peform", "cycles", "of", "binding-release", "of", "target", "proteins", "."], "h": {"id": "C1332371", "name": "C1332371#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [3, 4]}}
{"token": ["Furthermore", ",", "both", "the", "cytotoxicity", "and", "C1706006#ent", "<e1>", "concentration", "of", "cultured", "supernatants", "of", "activated", "PBMC", "incubated", "with", "C0011777#ent", "<e2>", "was", "significantly", "lower", "than", "that", "in", "the", "absence", "of", "C0011777#ent", "<e2>", "."], "h": {"id": "C1706006", "name": "C1706006#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [17, 18]}}
{"token": ["Herein", "is", "reported", "a", "singular", "case", "of", "antidepressant", "(", "amoxapine", "and", "citalopram", ")", "and", "C0040616#ent", "<e1>", "perphenazine", ")", "photo-distributed", "neutrophilic", "dermatosis", "and", "adult", "respiratory", "distress", "syndrome", "C0243025#ent", "<e2>", ")", "."], "h": {"id": "C0040616", "name": "C0040616#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0243025", "name": "C0243025#ent", "pos": [26, 27]}}
{"token": ["Genetic", "and", "pharmacological", "studies", "that", "Endothelin1", "(", "C1414260#ent", "<e1>", ")", "is", "a", "key", "signaling", "molecule", "patterning", "the", "facial", "skeleton", "C3274826#ent", "<e2>", ",", "chicks", ",", "and", "mice", "."], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3274826", "name": "C3274826#ent", "pos": [19, 20]}}
{"token": ["Vasopressin", "cells", "5-fold", "higher", "C1415301#ent", "<e1>", "(", "32", "%", ")", ",", "approximately", "half", "as", "much", "C1415300#ent", "<e2>", "mRNA", "(", "39", "%", ")", "and", "equivalent", "NR2D", "(", "31", "%", ")", "."], "h": {"id": "C1415301", "name": "C1415301#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415300", "name": "C1415300#ent", "pos": [15, 16]}}
{"token": ["C0012888#ent", "<e1>", "responsible", "for", "initiation", "of", "DNA", "synthesis", "C0012890#ent", "<e2>", "epsilon", "are", "required", "for", "elongation", "of", "DNA", "strand", "replication", "."], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012890", "name": "C0012890#ent", "pos": [8, 9]}}
{"token": ["Norfloxacin", ",", "ciprofloxacin", ",", "C0014310#ent", "<e1>", ",", "ofloxacin", ",", "and", "temafloxacin", "single-dose", "therapy", "demonstrated", "clinical", "efficacy", "C0018081#ent", "<e2>", "non-comparative", "and", "comparative", "trials", ",", "including", "bacterial", "eradication", "of", "isolates", "resistant", "to", "other", "agents", "."], "h": {"id": "C0014310", "name": "C0014310#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [16, 17]}}
{"token": ["C1333714#ent", "<e1>", "is", "a", "14", "amino", "acid", "peptide", "isolated", "from", "amphibian", "skin", "its", "mammalian", "C1334043#ent", "<e2>", "is", "gastrin-releasing", "peptide", "GRP", ")", "."], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}}
{"token": ["C1333714#ent", "<e1>", "and", "its", "mammalian", "C1334043#ent", "<e2>", ",", "gastrin-releasing", "peptide", "stimulate", "smooth", "muscle", "contraction", "may", "promote", "the", "growth", "of", "gastrointestinal", "tissues"], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}}
{"token": ["Analogues", "of", "the", "amphibian", "neuropeptide", "C1333714#ent", "<e1>", ",", "and", "of", "the", "mammalian", "C1334043#ent", "<e2>", ",", "gastrin-releasing", "peptide", "have", "been", "synthesized", "and", "their", "biological", "activity", "in", "small", "cell", "lung", "carcinoma", "rat", "pancreatic", "acinar", "cells"], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "dividing", "sympathetic", "precursors", "underwent", "apoptosis", "when", "treated", "with", "C0289993#ent", "<e1>", ",", "but", "not", "C0000481#ent", "<e2>", "at", "the", "same", "range", "of", "concentration", "."], "h": {"id": "C0289993", "name": "C0289993#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0000481", "name": "C0000481#ent", "pos": [16, 17]}}
{"token": ["Human", "C1418503#ent", "<e1>", ",", "a", "zymogen", "of", "one", "of", "the", "C2717969#ent", "<e2>", "was", "isolated", "and", "crystallized", "."], "h": {"id": "C1418503", "name": "C1418503#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2717969", "name": "C2717969#ent", "pos": [10, 11]}}
{"token": ["Pepsinogen", "C", "also", "known", "as", "C1418503#ent", "<e1>", "or", "pepsinogen", "II", "is", "an", "C2717969#ent", "<e2>", "expressed", "primarily", "in", "gastric", "chief", "cells", "."], "h": {"id": "C1418503", "name": "C1418503#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2717969", "name": "C2717969#ent", "pos": [12, 13]}}
{"token": ["ImmH.PO(4", ")", "complex", "is", "assigned", "to", "N-1H", "of", "C1709289#ent", "<e1>", "by", "using", "saturation-transferred", "NOE", "measurements", "on", "the", "C1417772#ent", "<e2>", "."], "h": {"id": "C1709289", "name": "C1709289#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417772", "name": "C1417772#ent", "pos": [17, 18]}}
{"token": ["At", "least", "several", "of", "the", "mammalian", "cells", "synthesized", "a", "C1305923#ent", "<e1>", "size", "of", "Pr180", ",", "the", "precursor", "to", "C1955880#ent", "<e2>"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [18, 19]}}
{"token": ["The", "localization", "of", "reverse", "transcriptase-related", "proteins", "polytene", "chromosomes", "dipterans", "was", "investigated", "using", "previously", "characterized", "antibodies", "to", "a", "C1305923#ent", "<e1>", "conserved", "motifs", "of", "insect", "C1955880#ent", "<e2>"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [23, 24]}}
{"token": ["A", "Trypanosoma", "brucei", "DNA", "element", "TRS-1", ",", "for", "trypanosome", "repeated", "sequence", ")", ",", "which", "seems", "transposable", ",", "may", "encode", "a", "1651", "C1305923#ent", "<e1>", "homology", "with", "C1955880#ent", "<e2>"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [25, 26]}}
{"token": ["In", "view", "of", "a", "cytoprotective", "effect", "C0596481#ent", "<e1>", "chemokine-mediated", "tissue", "injury", ",", "we", "examined", "the", "neuroprotective", "effect", "C0133951#ent", "<e2>", ",", "a", "specific", "inhibitor", "of", "neutrophil", "elastase", "in", "rats", "with", "spinal", "cord", "injury"], "h": {"id": "C0596481", "name": "C0596481#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0133951", "name": "C0133951#ent", "pos": [17, 18]}}
{"token": ["The", "case", "of", "a", "patient", "with", "C0521610#ent", "<e1>", "presented", "with", "complaints", "of", "lower", "abdominal", "pain", "dysuria", ",", "and", "C0232894#ent", "<e2>", "is", "presented", "."], "h": {"id": "C0521610", "name": "C0521610#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0232894", "name": "C0232894#ent", "pos": [18, 19]}}
{"token": ["Changes", "in", "plasma", "membrane", "may", "be", "crucial", "in", "the", "alterations", "of", "ion", "flux", "evoked", "C3536742#ent", "<e1>", "release", "caused", "by", "C0056650#ent", "<e2>", "."], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0056650", "name": "C0056650#ent", "pos": [19, 20]}}
{"token": ["By", "immunolabeling", "of", "cryosections", ",", "we", "have", "characterized", "in", "rat", "cardiac", "myocytes", "cation-independent", "mannose-6-phosphate", "receptor", "MPR", ")", ",", "a", "lysosomal", "membrane", "glycoprotein", "lgp120", ",", "and", "a", "lysosomal", "enzyme", "C1332807#ent", "<e1>", "(", "homologous", "to", "C0054871#ent", "<e2>", "."], "h": {"id": "C1332807", "name": "C1332807#ent", "pos": [28, 29]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [33, 34]}}
{"token": ["We", "report", "a", "49-year-old", "patient", ",", "treated", "with", "C0008269#ent", "<e1>", "for", "21", "years", "for", "a", "systemic", "lupus", "erythematosus", "a", "C0024138#ent", "<e2>", "who", "presented", "a", "complete", "atrioventricular", "block", "required", "implantation", "of", "a", "cardiac", "pacemaker", "emergency", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [19, 20]}}
{"token": ["The", "first", "two", "class", "III", "antiarrhythmic", "drugs", "that", "became", "available", ",", "C0026289#ent", "<e1>", "and", "amiodarone", ",", "also", "have", "potent", "C0242889#ent", "<e2>", "actions", "."], "h": {"id": "C0026289", "name": "C0026289#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [19, 20]}}
{"token": ["C0026289#ent", "<e1>", "is", "a", "nonselective", "beta-adrenoceptor", "antagonist", "prolongs", "cardiac", "repolarisation", "independently", "of", "its", "C0242889#ent", "<e2>", "class", "III", "antiarrhythmic", "properties", ")", "."], "h": {"id": "C0026289", "name": "C0026289#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [13, 14]}}
{"token": ["We", "have", "analysed", "the", "phosphorylation", "dependence", "of", "the", "C1332924#ent", "<e1>", "and", "thermoresistance-mediating", "properties", "of", "the", "small", "heat", "shock", "protein", "C1333928#ent", "<e2>", "."], "h": {"id": "C1332924", "name": "C1332924#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333928", "name": "C1333928#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", "we", "searched", "for", "restriction", "fragment", "length", "polymorphisms", "RFLP", ")", "in", "the", "human", "interleukin-1", "beta", "C1708431#ent", "<e1>", "for", "correlations", "to", "monocyte", "(", "Mo", ")", "function", "in", "C1418941#ent", "<e2>", "healthy", "donors", "and", "insulin-dependent", "diabetic", "patients", "."], "h": {"id": "C1708431", "name": "C1708431#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1418941", "name": "C1418941#ent", "pos": [29, 30]}}
{"token": ["We", "demonstrate", "that", "during", "zinc", "starvation", ",", "C1428407#ent", "<e1>", "is", "required", "for", "the", "repression", "of", "C1412235#ent", "<e2>", "expression", "."], "h": {"id": "C1428407", "name": "C1428407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412235", "name": "C1412235#ent", "pos": [15, 16]}}
{"token": ["Secondary", "vasospasm", "can", "occur", "in", "a", "number", "of", "autoimmune", "diseases", "such", "as", "multiple", "sclerosis", "lupus", "erythematosus", "antiphospholipid", "syndrome", "C0035436#ent", "<e1>", "giant", "cell", "arteritis", "Behcet's", "disease", "Buerger's", "disease", "preeclampsia", ",", "and", "also", "in", "C0009450#ent", "<e2>", "as", "AIDS", "."], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [32, 33]}}
{"token": ["We", "have", "examined", "the", "role", "of", "elevated", "C0812281#ent", "<e1>", "dissipation", "in", "the", "prevention", "of", "T1D", "using", "the", "C1334512#ent", "<e2>", "mouse", "strain"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334512", "name": "C1334512#ent", "pos": [17, 18]}}
{"token": ["carotovora", "(", "Ecc", ")", "encodes", "the", "C0086376#ent", "<e1>", "of", "the", "type", "II", "general", "secretory", "pathway", "C1706339#ent", "<e2>", ")", "apparatus", "which", "is", "required", "for", "secretion", "of", "pectinase", "and", "cellulase", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706339", "name": "C1706339#ent", "pos": [15, 16]}}
{"token": ["Collectively", ",", "these", "data", "suggest", "that", "CaM", "kinase", "II", "activate", "MAP", "kinase", "which", "in", "turn", "activates", "C1333201#ent", "<e1>", "to", "release", "AA", "for", "C0072259#ent", "<e2>", "the", "rabbit", "VSMC", "."], "h": {"id": "C1333201", "name": "C1333201#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0072259", "name": "C0072259#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "the", "ligand-binding", "properties", "C1421449#ent", "<e1>", "(", "F-actin", ",", "G-actin", ",", "calcium", ",", "phospholipids", "and", "C0136864#ent", "<e2>", "mechanistically", "important", "for", "the", "crosstalk", "between", "signaling", "pathways", "actin", "reorganization", "epithelial", "cells"], "h": {"id": "C1421449", "name": "C1421449#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0136864", "name": "C0136864#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "indicate", "that", "patients", "with", "C1956415#ent", "<e1>", "are", "not", "true", "C0003872#ent", "<e2>", ",", "and", "that", "C1956415#ent", "<e1>", "and", "psoriasis", "are", "different", "etiological", "entities", "."], "h": {"id": "C0003872", "name": "C0003872#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1956415", "name": "C1956415#ent", "pos": [6, 7]}}
{"token": ["Intravenous", "injection", "of", "C0085826#ent", "<e1>", "rabbits", "produced", "profound", "but", "transient", "C0040034#ent", "<e2>", "unaccompanied", "by", "significant", "changes", "in", "circulating", "leucocytes", "."], "h": {"id": "C0085826", "name": "C0085826#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [10, 11]}}
{"token": ["C0085826#ent", "<e1>", "GPIIIa49", "-", "66", "Ab", "of", "HIV-related", "thrombocytopenic", "patients", "induces", "C0040034#ent", "<e2>", "and", "platelet", "fragmentation", "the", "generation", "of", "peroxide", "and", "other", "reactive", "oxygen", "species", "ROS", ")", "."], "h": {"id": "C0085826", "name": "C0085826#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [11, 12]}}
{"token": ["C0206061#ent", "<e1>", "in", "two", "patients", "on", "C0012289#ent", "<e2>", "and", "was", "reversible", "in", "each", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012289", "name": "C0012289#ent", "pos": [6, 7]}}
{"token": ["Similar", "to", "the", "C0026574#ent", "<e1>", "it", "carries", "the", "C3853646#ent", "<e2>", "oncogene", "."], "h": {"id": "C0026574", "name": "C0026574#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853646", "name": "C3853646#ent", "pos": [8, 9]}}
{"token": ["Previously", "described", "genomic", "sequences", "related", "to", "C0026574#ent", "<e1>", "human", "mos", "pseudogene", "gp5", "and", "main", "C3853646#ent", "<e2>", ",", "are", "either", "totally", "silent", "or", "show", "highly", "limited", "degree", "of", "expression", "in", "some", "specialized", "tissues"], "h": {"id": "C0026574", "name": "C0026574#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853646", "name": "C3853646#ent", "pos": [14, 15]}}
{"token": ["We", "compared", "the", "growth-inhibitory", "effects", "and", "inhibition", "profile", "the", "C0038085#ent", "<e1>", "SFKs", ")", "of", "C0939537#ent", "<e2>", ",", "dasatinib", ",", "nilotinib", "and", "INNO-406", "."], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0939537", "name": "C0939537#ent", "pos": [14, 15]}}
{"token": ["--Although", "it", "is", "clear", "that", "this", "C1568272#ent", "<e1>", "not", "an", "C1290884#ent", "<e2>", "the", "tendon", ",", "the", "cause", "of", "the", "degeneration", "of", "the", "tendon", "fibres", "not", "understood", "."], "h": {"id": "C1568272", "name": "C1568272#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [10, 11]}}
{"token": ["The", "heterogeneity", "of", "the", "C1801950#ent", "<e1>", "phenomenon", "according", "to", "the", "stage", "of", "tumor", "growth", "be", "a", "major", "obstacle", "for", "uptake", "of", "C0033978#ent", "<e2>", "do", "not", "cross", "the", "C1801950#ent", "<e1>", "easily", "."], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1801950", "name": "C1801950#ent", "pos": [4, 5]}}
{"token": ["In", "these", "cells", "C0879392#ent", "<e1>", "transports", "daunorubicin", ",", "and", "C3539701#ent", "<e2>", "vinblastine", ";", "both", "transporters", "export", "reduced", "glutathione", "(", "GSH", ")", "into", "the", "medium", "."], "h": {"id": "C0879392", "name": "C0879392#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539701", "name": "C3539701#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "in", "ovarian", "carcinoma", "C0879392#ent", "<e1>", "expression", "is", "associated", "with", "C3539701#ent", "<e2>", "and", "P-gp", "expression", ",", "whereas", "LRP", "expression", "is", "associated", "with", "clinicopathological", "characteristics", "."], "h": {"id": "C0879392", "name": "C0879392#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539701", "name": "C3539701#ent", "pos": [12, 13]}}
{"token": ["The", "human", "multidrug", "resistance", "C0879392#ent", "<e1>", "and", "its", "homolog", ",", "C3539701#ent", "<e2>", ",", "are", "both", "suggested", "as", "being", "involved", "in", "cancer", "drug", "resistance", "the", "transport", "of", "organic", "anions"], "h": {"id": "C0879392", "name": "C0879392#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539701", "name": "C3539701#ent", "pos": [10, 11]}}
{"token": ["The", "majority", "of", "allergen-specific", "T", "cells", "derived", "from", "inhalant", "allergen", "patch", "test", "lesions", "in", "patients", "with", "C0013595#ent", "<e1>", "previously", "found", "to", "produce", "a", "restricted", "C1333360#ent", "<e2>", "cytokine", "pattern", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333360", "name": "C1333360#ent", "pos": [24, 25]}}
{"token": ["Diethylstilbestrol", "(", "DES", ")", "has", "been", "found", "to", "be", "oxidized", "in", "Syrian", "hamster", "embryo", "(", "C1822717#ent", "<e1>", ")", "cells", "by", "prostaglandin-H", "synthase", "C1565830#ent", "<e2>", "."], "h": {"id": "C1822717", "name": "C1822717#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [22, 23]}}
{"token": ["The", "effect", "of", "intracellular", "cAMP", "and", "C0010674#ent", "<e1>", "regulator", "(", "CFTR", ")", "protein", "on", "the", "C1332764#ent", "<e2>", "ICaCl", ")", "present", "in", "parotid", "acinar", "cells", "studied", "using", "the", "patch", "clamp", "technique"], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [6, 7]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332764", "name": "C1332764#ent", "pos": [15, 16]}}
{"token": ["It", "is", "concluded", "that", "prostacyclin", ",", "C0534183#ent", "<e1>", "and", "L-NNA", "can", "act", "as", "C0033613#ent", "<e2>", "LPS-induced", "loss", "of", "red", "blood", "cell", "."], "h": {"id": "C0534183", "name": "C0534183#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033613", "name": "C0033613#ent", "pos": [13, 14]}}
{"token": ["Muscle", "contusion", "induced", "more", "rapid", ",", "prominent", "transactivations", "of", "C1705882#ent", "<e1>", "and", "RET", "C1417679#ent", "<e2>", "in", "motoneurons", "than", "did", "sciatic", "nerve", "axotomy", "."], "h": {"id": "C1705882", "name": "C1705882#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["C1705882#ent", "<e1>", "is", "a", "member", "of", "a", "group", "of", "C1417679#ent", "<e2>", "whose", "activities", "are", "cell", "cycle", "regulated", "and", "that", "are", "transcriptionally", "induced", "in", "response", "to", "the", "stress", "of", "DNA", "damage"], "h": {"id": "C1705882", "name": "C1705882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}}
{"token": ["dun1", "mutants", "are", "also", "defective", "for", "RNR1", "and", "C1705882#ent", "<e1>", "induction", "but", "are", "proficient", "for", "induction", "of", "other", "C1417679#ent", "<e2>", ",", "defining", "the", "existence", "of", "at", "least", "two", "distinct", "DNA", "damage", "induction", "pathways"], "h": {"id": "C1705882", "name": "C1705882#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["However", ",", "Lassa", "virus", "hepatitis", "be", "differentiated", "from", "liver", "lesions", "in", "yellow", "fever", "C0024788#ent", "<e1>", "and", "Ebola", "(", "Maridi", ")", "C0019104#ent", "<e2>"], "h": {"id": "C0024788", "name": "C0024788#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [20, 21]}}
{"token": ["In", "1987", ",", "an", "isolated", "case", "of", "fatal", "C0024788#ent", "<e1>", "recognized", "during", "routine", "C0019104#ent", "<e2>", "conducted", "in", "Kenya", "."], "h": {"id": "C0024788", "name": "C0024788#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [13, 14]}}
{"token": ["The", "C0039082#ent", "<e1>", "of", "hyperandrogenism", ",", "insulin", "resistance", "and", "acanthosis", "nigricans", "C1963745#ent", "<e2>", "is", "one", "presentation", "of", "the", "insulin-resistant", "subset", "of", "polycystic", "ovary", "syndrome"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C1963745", "name": "C1963745#ent", "pos": [11, 12]}}
{"token": ["The", "initial", "loss", "of", "growth", "control", "the", "spontaneously", "regressing", "neuroblastomas", "might", "be", "the", "result", "of", "an", "C0221406#ent", "<e1>", "of", "trophic", "and", "C1332817#ent", "<e2>", "by", "a", "shortage", "or", "absence", "of", "factors", "initiating", "neuronal", "differentiation"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332817", "name": "C1332817#ent", "pos": [21, 22]}}
{"token": ["Tumor", "necrosis", "factor", "TNF", ")", "inhibitors", ",", "such", "as", "infliximab", ",", "are", "highly", "effective", "in", "the", "management", "of", "rheumatoid", "arthritis", "however", ",", "these", "C0991617#ent", "<e1>", "are", "associated", "with", "increased", "risk", "of", "C0032965#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0032965", "name": "C0032965#ent", "pos": [31, 32]}}
{"token": ["We", "studied", "the", "expression", "of", "several", "differentiating", "characteristics", "and", "detected", "the", "presence", "of", "C0398709#ent", "<e1>", "lysozyme", "in", "some", "tumour", "cells", "whereas", "keratin", "and", "C0071874#ent", "<e2>", "were", "consistently", "absent", "."], "h": {"id": "C0398709", "name": "C0398709#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0071874", "name": "C0071874#ent", "pos": [23, 24]}}
{"token": ["Immunoprecipitated", "Bcr-AblY253H", "and", "C4085851#ent", "<e1>", "similar", "kinase", "activities", "substrate", "phosphorylation", "patterns", "as", "C1835417#ent", "<e2>", "wildtype", "."], "h": {"id": "C4085851", "name": "C4085851#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1835417", "name": "C1835417#ent", "pos": [12, 13]}}
{"token": ["The", "physical", "and", "chemical", "compatibility", "C0220578#ent", "<e1>", "with", "cyclophosphamide", "and", "with", "C0020823#ent", "<e2>", "during", "simulated", "Y-site", "administration", "was", "studied", "."], "h": {"id": "C0220578", "name": "C0220578#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [11, 12]}}
{"token": ["However", ",", "C0020097#ent", "<e1>", "human", "osteosarcoma", "cells", "not", "express", "C1705979#ent", "<e2>", "alpha-CAT", "constructs", "."], "h": {"id": "C0020097", "name": "C0020097#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705979", "name": "C1705979#ent", "pos": [9, 10]}}
{"token": ["Several", "new", "therapies", ",", "including", "tizanidine", ",", "C0004609#ent", "<e1>", "botulinum", "toxin", "injections", ",", "gabapentin", ",", "C0061851#ent", "<e2>", ",", "thalamic", "stimulation", "and", "lamotrigine", ",", "increase", "our", "treatment", "options", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061851", "name": "C0061851#ent", "pos": [15, 16]}}
{"token": ["C1425324#ent", "<e1>", "also", "stimulated", "translation", "of", "an", "C1706141#ent", "<e2>", "5", "'", "UTR-driven", "template", "in", "HeLa", "cell", "that", "were", "depleted", "of", "essential", "factors", "addition", "of", "RNA", "oligonucleotides", "the", "viral", "5'", "UTR", "RNA"], "h": {"id": "C1425324", "name": "C1425324#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706141", "name": "C1706141#ent", "pos": [7, 8]}}
{"token": ["In", "10", "of", "49", "attacks", "of", "C0037199#ent", "<e1>", "the", "concurrent", "disease", "(", "e.g.", "C0085315#ent", "<e2>", "malignant", "non-Hodgkin", "lymphoma", "had", "not", "been", "recognized", "by", "the", "referring", "doctor", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085315", "name": "C0085315#ent", "pos": [13, 14]}}
{"token": ["They", "differed", "from", "other", "C1334308#ent", "<e1>", "having", "high", "pHi", "values", "of", "6.20", "(", "C1420464#ent", "<e2>", ")", "and", "6.85", "(", "rK9", ")", "."], "h": {"id": "C1334308", "name": "C1334308#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420464", "name": "C1420464#ent", "pos": [13, 14]}}
{"token": ["From", "our", "results", ",", "we", "have", "concluded", "that", "C1538716#ent", "<e1>", "performs", "a", "critical", "function", "in", "hypertonicity-induced", "C1527149#ent", "<e2>", "induction", ",", "and", "finally", "cellular", "protection", "via", "the", "indirect", "regulation", "of", "TonEBP", "modification", "."], "h": {"id": "C1538716", "name": "C1538716#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [16, 17]}}
{"token": ["This", "mechanism", "appears", "to", "be", "prominent", "in", "C0038454#ent", "<e1>", "other", "neurodegenerative", "processes", "which", "C1538577#ent", "<e2>", "and", "PARP-inhibiting", "drugs", "provide", "major", "protection", "."], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538577", "name": "C1538577#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "C1538606#ent", "<e1>", "with", "peptide", ":", "C0140649#ent", "<e2>", "C1538606#ent", "<e1>", "down", "shift", "in", "the", "NaDodSO4-PAGE", "gel", ",", "indicating", "that", "C1538606#ent", "<e1>", "is", "a", "glycoprotein", "."], "h": {"id": "C1538606", "name": "C1538606#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0140649", "name": "C0140649#ent", "pos": [7, 8]}}
{"token": ["We", "aimed", "to", "analyze", "the", "effects", "of", "nicorandil", ",", "an", "C1955862#ent", "<e1>", "vasodilator", ",", "on", "mitochondrial", "function", "rat", "hearts", "and", "cardiac", "C1425400#ent", "<e2>", "to", "ischemia-reperfusion", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1425400", "name": "C1425400#ent", "pos": [21, 22]}}
{"token": ["When", "mutated", "C1706017#ent", "<e1>", "and", "BMPR-IB", "were", "transiently", "transfected", "into", "C2C12", "cells", ",", "both", "C1706017#ent", "<e1>", "and", "BMPR-IB", "similarly", "induced", "C3812647#ent", "<e1>", "activity", "in", "the", "absence", "of", "BMP-2", "."], "h": {"id": "C1706017", "name": "C1706017#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3812647", "name": "C3812647#ent", "pos": [20, 21]}}
{"token": ["Thus", "C3541396#ent", "<e1>", "is", "critical", "in", "transcriptional", "regulation", "apoAI", "gene", "expression", "in", "C0669372#ent", "<e2>", "."], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}}
{"token": ["In", "human", "preterm", "infants", "lower", "pulmonary", "C1420314#ent", "<e1>", "has", "been", "associated", "with", "severe", "C0035204#ent", "<e2>"], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [13, 14]}}
{"token": ["As", "a", "result", ",", "the", "direct", "costs", "of", "treatment", "for", "C0018802#ent", "<e1>", "or", "cardiovascular", "diseases", "patients", "treated", "with", "C0076840#ent", "<e2>", "were", "less", "than", "those", "with", "furosemide", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0076840", "name": "C0076840#ent", "pos": [18, 19]}}
{"token": ["To", "compare", "the", "direct", "healthcare", "costs", "patients", "with", "congestive", "heart", "failure", "C0018802#ent", "<e1>", ")", "prescribed", "torasemide", "(", "C0076840#ent", "<e2>", ")", "or", "furosemide", "(", "frusemide", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0076840", "name": "C0076840#ent", "pos": [17, 18]}}
{"token": ["To", "compare", "the", "direct", "healthcare", "costs", "patients", "with", "C0018802#ent", "<e1>", "CHF", ")", "prescribed", "torasemide", "(", "C0076840#ent", "<e2>", ")", "or", "furosemide", "(", "frusemide", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0076840", "name": "C0076840#ent", "pos": [15, 16]}}
{"token": ["Initial", "C0006230#ent", "<e1>", "in", "cessation", "of", "C0002453#ent", "<e2>", "and", "normalization", "of", "PRL", "levels", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0002453", "name": "C0002453#ent", "pos": [6, 7]}}
{"token": ["Both", "C0073096#ent", "<e1>", "and", "quercetin", "dose-dependently", "inhibited", "the", "contractile", "response", "C3887648#ent", "<e2>", "(", "NA", ")", "in", "isolated", "endothelium-intact", "rat", "aorta", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [10, 11]}}
{"token": ["Expression", "of", "C1706269#ent", "<e1>", "(", "NMDA", ")", "and", "C1415288#ent", "<e2>", "(", "AMPA", ")", "receptor", "subtypes", "was", "examined", "immunohistochemically", "."], "h": {"id": "C1706269", "name": "C1706269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415288", "name": "C1415288#ent", "pos": [8, 9]}}
{"token": ["Epileptic", "rats", "perfused", "14", "d", "after", "TT", "injection", "showed", "a", "focus", "of", "increased", "GAD-67", "and", "C1706269#ent", "<e1>", ",", "and", "of", "decreased", "alpha-CaMKII", "and", "C1415288#ent", "<e2>", "mRNA", "levels", "at", "the", "injection", "site"], "h": {"id": "C1706269", "name": "C1706269#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415288", "name": "C1415288#ent", "pos": [23, 24]}}
{"token": ["This", "change", "was", "specific", "for", "C1706269#ent", "<e1>", "and", "not", "for", "C1415288#ent", "<e2>", "."], "h": {"id": "C1706269", "name": "C1706269#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415288", "name": "C1415288#ent", "pos": [10, 11]}}
{"token": ["C0268579#ent", "<e1>", "a", "rare", "C0019247#ent", "<e2>", "associated", "with", "medical", "problems", "."], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [4, 5]}}
{"token": ["C1705717#ent", "<e1>", ",", "a", "Wnt", "signal", "regulator", ",", "enhances", "C0033640#ent", "<e2>", "phosphorylation", "of", "beta-catenin", "and", "stimulates", "the", "degradation", "of", "beta-catenin", "."], "h": {"id": "C1705717", "name": "C1705717#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [9, 10]}}
{"token": ["Differentiation", "of", "skin", "stem", "cells", "hair", "follicles", "HFs", ")", "requires", "the", "inhibition", "of", "beta-catenin", "degradation", ",", "which", "is", "controlled", "by", "a", "complex", "containing", "C1705717#ent", "<e1>", "and", "the", "C0033640#ent", "<e2>", "GSK3beta", "."], "h": {"id": "C1705717", "name": "C1705717#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [27, 28]}}
{"token": ["A", "diagnosis", "of", "C0027849#ent", "<e1>", "made", ",", "and", "the", "patient", "was", "given", "C0010977#ent", "<e2>", "with", "prompt", "and", "complete", "resolution", "of", "all", "signs", "and", "symptoms", "."], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0010977", "name": "C0010977#ent", "pos": [12, 13]}}
{"token": ["One", "mole", "of", "C-II", "inhibited", "one", "mole", "each", "of", "bovine", "trypsin", "C0008742#ent", "<e1>", "probably", "at", "the", "same", "site", ",", "and", "porcine", "C0699918#ent", "<e2>", "at", "another", "reactive", "site"], "h": {"id": "C0008742", "name": "C0008742#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [21, 22]}}
{"token": ["The", "mouse", "genes", "the", "serine", "proteases", "trypsin", "Try-1", ")", ",", "C0008742#ent", "<e1>", "Ctrb", ")", ",", "and", "C0699918#ent", "<e2>", "(", "Ela-1", ")", "were", "chromosomally", "assigned", "using", "Southern", "blot", "hybridization", "mouse", "X", "Chinese", "cell", "hybrid", "DNA", "."], "h": {"id": "C0008742", "name": "C0008742#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [16, 17]}}
{"token": ["The", "C0265308#ent", "<e1>", "a", "rare", "malformation", "syndrome", "C0010278#ent", "<e2>", "."], "h": {"id": "C0265308", "name": "C0265308#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [7, 8]}}
{"token": ["The", "C0265308#ent", "<e1>", "identified", "by", "radial", "aplasia", "C0010278#ent", "<e2>", "."], "h": {"id": "C0265308", "name": "C0265308#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [7, 8]}}
{"token": ["Gelling", "agents", "strongly", "affected", "ABA", "adsorption", ",", "with", "C0026818#ent", "<e1>", "decreasing", "the", "adsorption", "of", "ABA", "compared", "to", "C0061182#ent", "<e2>", "Gelrite", ",", "Phytagel", ")", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0061182", "name": "C0061182#ent", "pos": [17, 18]}}
{"token": ["After", "comparison", "with", "C0026818#ent", "<e1>", ",", "alginate", ",", "and", "kappa-carrageenan", ",", "C0061182#ent", "<e2>", "selected", "as", "the", "optimal", "immobilization", "support", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0061182", "name": "C0061182#ent", "pos": [11, 12]}}
{"token": ["The", "human", "C1423784#ent", "<e1>", "SMO(PAOh1", ")", ",", "is", "one", "C0027203#ent", "<e2>", "that", "may", "play", "a", "direct", "role", "in", "the", "cellular", "response", "the", "antitumour", "polyamine", "analogues", "."], "h": {"id": "C1423784", "name": "C1423784#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["Besides", "the", "C1701467#ent", "<e1>", "several", "cytosolic", "and", "one", "mitochondrial", "C3540790#ent", "<e2>", "have", "been", "described", "."], "h": {"id": "C1701467", "name": "C1701467#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [9, 10]}}
{"token": ["Because", "other", "T-lymphocyte-mediated", ",", "chronic", "inflammatory", "disorders", "been", "associated", "with", "elevated", "C0061878#ent", "<e1>", "grB", ")", "expression", "we", "tested", "the", "hypothesis", "that", "C0155877#ent", "<e2>", "be", "associated", "with", "elevated", "grB", "levels", "in", "the", "bronchoalveolar", "compartment"], "h": {"id": "C0061878", "name": "C0061878#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0155877", "name": "C0155877#ent", "pos": [21, 22]}}
{"token": ["Protein", "kinase", "B", "PKB", ")", "and", "PKCzeta", "are", "known", "C1709402#ent", "<e1>", "targets", "in", "the", "regulation", "of", "C2982484#ent", "<e2>", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "both", "Tyr(612", ")", "and", "Tyr(632", ")", "are", "important", "for", "IRS-1", "to", "fully", "activate", "C1709402#ent", "<e1>", "mediate", "translocation", "of", "C2982484#ent", "<e2>", "in", "response", "to", "insulin", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [20, 21]}}
{"token": ["The", "effect", "of", "metoprolol", "on", "chest", "pain", "been", "assessed", "in", "terms", "of", "the", "C2926735#ent", "<e1>", "and", "the", "use", "of", "C0027409#ent", "<e2>", "nitrates", "and", "calcium-channel", "blockers"], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027409", "name": "C0027409#ent", "pos": [19, 20]}}
{"token": ["The", "risk", "of", "C0949083#ent", "<e1>", "atelectasis", "is", "high", "among", "critically", "ill", "C2350558#ent", "<e2>", "patients", "."], "h": {"id": "C0949083", "name": "C0949083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [11, 12]}}
{"token": ["On", "the", "other", "hand", ",", "the", "C1412332#ent", "<e1>", "level", "of", "BALF", "samples", "obtained", "from", "patients", "with", "C0002390#ent", "<e2>", "increased", "versus", "in", "healthy", "subjects"], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002390", "name": "C0002390#ent", "pos": [16, 17]}}
{"token": ["The", "same", "stimuli", "activated", "C0752312#ent", "<e1>", "MAP", ")", "kinase", "in", "J.CaM1", "cells", "transfected", "with", "C3853652#ent", "<e2>", ",", "demonstrating", "that", "C3853652#ent", "<e2>", "plays", "a", "critical", "role", "in", "MAP", "kinase", "activation"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3853652", "name": "C3853652#ent", "pos": [14, 15]}}
{"token": ["In", "C0339961#ent", "<e1>", "compared", "to", "other", "diagnoses", ",", "C0270697#ent", "<e2>", "and", "papulonecrotic", "skin", "lesions", "were", "common", "findings", ",", "but", "no", "factor", "a", "significant", "association", "."], "h": {"id": "C0339961", "name": "C0339961#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [8, 9]}}
{"token": ["In", "C0339961#ent", "<e1>", "compared", "to", "other", "diagnoses", ",", "C0270697#ent", "<e2>", "and", "papulonecrotic", "skin", "lesions", "were", "common", "findings", ",", "but", "no", "factor", "had", "a", "significant", "association", "."], "h": {"id": "C0339961", "name": "C0339961#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [8, 9]}}
{"token": ["C1416660#ent", "<e1>", "was", "rapidly", "up-regulated", "in", "PDGF-BB-treated", ",", "cultured", "C1539322#ent", "<e2>", ",", "and", "a", "small", "interfering", "RNA", "to", "C1416660#ent", "<e1>", "partially", "blocked", "PDGF-BB-induced", "C1539322#ent", "<e2>", "gene", "repression"], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416660", "name": "C1416660#ent", "pos": [0, 1]}}
{"token": ["C0035400#ent", "<e1>", "a", "reversible", "metabolic", "encephalopathy", "C0023895#ent", "<e2>", ",", "offers", "a", "unique", "opportunity", "to", "investigate", "the", "pharmacologic", "mechanisms", "which", "a", "toxic-metabolic", "insult", "to", "mitochondria", "is", "translated", "into", "neurochemical", "and", "neurologic", "dysfunction"], "h": {"id": "C0035400", "name": "C0035400#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [6, 7]}}
{"token": ["The", "clinical", "characteristics", "15", "patients", "with", "C3160718#ent", "<e1>", "living", "in", "Greece", "with", "the", "Ala53Thr", "C1420276#ent", "<e2>", "alpha-synPD", ")", "were", "compared", "with", "patients", "with", "sporadic", "Parkinson's", "disease", "sPD", ")", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [14, 15]}}
{"token": ["If", "conserved", "in", "humans", ",", "we", "suggest", "that", "upregulation", "of", "parkin", "may", "prove", "a", "method", "of", "suppression", "for", "C3160718#ent", "<e1>", "induced", "by", "mutant", "forms", "of", "C1420276#ent", "<e2>", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [25, 26]}}
{"token": ["However", ",", "PHLDA1", "expression", "was", "associated", "with", "increased", "basal", "apoptosis", "assessed", "by", "live", "cell", "annexin", "V", "binding", "C1333243#ent", "<e1>", "and", "with", "increased", "cleavage", "of", "C1538577#ent", "<e2>", "caspase-9", "."], "h": {"id": "C1333243", "name": "C1333243#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1538577", "name": "C1538577#ent", "pos": [24, 25]}}
{"token": ["However", ",", "ASFV-infected", "endothelial", "cells", "died", "by", "apoptosis", ",", "detected", "morphologically", "by", "C1333243#ent", "<e1>", "nuclear", "condensation", "biochemically", "by", "C1538577#ent", "<e2>", "PARP", ")", "cleavage", "at", "4", "h", "postinfection", "(", "hpi", ")", "."], "h": {"id": "C1333243", "name": "C1333243#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1538577", "name": "C1538577#ent", "pos": [18, 19]}}
{"token": ["C1539593#ent", "<e1>", "GPAM", ")", "is", "the", "C0014442#ent", "<e2>", "that", "catalyses", "the", "initial", "and", "committed", "step", "of", "glycerolipid", "synthesis", ",", "therefore", ",", "it", "is", "a", "potential", "site", "for", "triacylglycerol", "synthesis", "regulation", "."], "h": {"id": "C1539593", "name": "C1539593#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}}
{"token": ["Fatty", "acid", "synthase", "FASN", ")", "and", "C1539593#ent", "<e1>", "GPAM", ")", "are", "two", "C0014442#ent", "<e2>", "that", "play", "a", "central", "role", "in", "de", "novo", "lipogenesis", "."], "h": {"id": "C1539593", "name": "C1539593#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["Molecular", "diagnosis", "N-acetylglutamate", "synthase", "deficiency", "C0268543#ent", "<e1>", ")", "has", "become", "possible", "now", "that", "the", "corresponding", "C0079429#ent", "<e2>", "has", "been", "identified", "."], "h": {"id": "C0268543", "name": "C0268543#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["A", "gene", "named", "C1422819#ent", "<e1>", "+", "encoding", "a", "C1512488#ent", "<e2>", "the", "yeast", "and", "human", "histone", "deacetylases", "such", "as", "Saccharomyces", "cerevisiae", "and", "human", "HDAC1", ",", "was", "cloned", "from", "Schizosaccharomyces", "pombe"], "h": {"id": "C1422819", "name": "C1422819#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [8, 9]}}
{"token": ["Keratoconjunctivitis", "sicca", "keratitis", ",", "scleritis", ",", "uveitis", ",", "C0152026#ent", "<e1>", "choroidopathy", ",", "and", "their", "associations", "with", "C0003873#ent", "<e2>", "systemic", "lupus", "erythematosus", "systemic", "sclerosis", "psoriatic", "arthritis", "juvenile", "idiopathic", "arthritis", "and", "polymyositis", "are", "reviewed", "."], "h": {"id": "C0152026", "name": "C0152026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["The", "new", "generation", "of", "C0035339#ent", "<e1>", ",", "the", "RXR", "selective", "agonists", "like", "C0765273#ent", "<e2>", ",", "represent", "a", "promising", "approach", "for", "refractory", "or", "persistent", "MF", "that", "is", "unresponsive", "to", "first-line", "therapies", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0765273", "name": "C0765273#ent", "pos": [12, 13]}}
{"token": ["Ramosetron", ",", "YM114", "(", "C0252141#ent", "<e1>", ",", "(-)-(R)-5-[(1-indolinyl)carbonyl]-4,5,6,7-tetrahydro-1", "H-benzimidazole", "monohydrochloride", ")", "and", "C0061863#ent", "<e2>", "concentration-dependently", "antagonized", "the", "Isc", "responses", "2-methyl-5-HT", "with", "reduction", "in", "the", "maximal", "response", "higher", "concentrations", "."], "h": {"id": "C0252141", "name": "C0252141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0061863", "name": "C0061863#ent", "pos": [12, 13]}}
{"token": ["We", "compared", "the", "efficacy", "and", "upper", "gastrointestinal", "safety", "the", "cyclooxygenase-2-specific", "inhibitor", "C0913246#ent", "<e1>", "with", "naproxen", "and", "placebo", "in", "treating", "moderate", "to", "severe", "C0029408#ent", "<e2>", "of", "the", "knee", "."], "h": {"id": "C0913246", "name": "C0913246#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [22, 23]}}
{"token": ["In", "well", "designed", "trials", ",", "C0913246#ent", "<e1>", "demonstrated", "efficacy", "versus", "placebo", "in", "patients", "with", "C0029408#ent", "<e2>", "(", "OA", ")", ",", "rheumatoid", "arthritis", "RA", ")", ",", "primary", "dysmenorrhoea", "postoperative", "pain"], "h": {"id": "C0913246", "name": "C0913246#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [14, 15]}}
{"token": ["Eosinophilic", "otitis", "media", "EOM", ")", "is", "characterized", "by", "the", "extensive", "accumulation", "of", "eosinophils", "in", "the", "middle", "ear", "mucosa", "C0029883#ent", "<e1>", "is", "usually", "associated", "with", "C0004096#ent", "<e2>"], "h": {"id": "C0029883", "name": "C0029883#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [24, 25]}}
{"token": ["These", "C3539946#ent", "<e1>", "also", "transported", "into", "the", "muscle", "in", "a", "C0058980#ent", "<e2>", "manner", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [10, 11]}}
{"token": ["Further", ",", "resveratrol", "inhibited", "C1417708#ent", "<e1>", "induced", "by", "TRIF", ",", "but", "not", "by", "C1417530#ent", "<e2>", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417530", "name": "C1417530#ent", "pos": [13, 14]}}
{"token": ["The", "rapid", "induction", "of", "IkappaBalpha", "(", "index", "of", "C1417708#ent", "<e1>", "and", "up-regulation", "of", "the", "adaptor", "protein", "C1417530#ent", "<e2>", "suggest", "that", "LPS-induced", "TLR2", "transcription", "may", "be", "dependent", "on", "the", "NF-kappaB", "pathway"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417530", "name": "C1417530#ent", "pos": [16, 17]}}
{"token": ["Of", "all", "of", "the", "sequences", "compared", ",", "C1334480#ent", "<e1>", "is", "the", "most", "homologous", "to", "rat", "C0246486#ent", "<e2>", "."], "h": {"id": "C1334480", "name": "C1334480#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0246486", "name": "C0246486#ent", "pos": [15, 16]}}
{"token": ["Cholera", "toxin", "alters", "intestinal", "function", "stimulation", "of", "adenylyl", "cyclase", "C1137703#ent", "<e1>", "cyclizing", ")", "or", "C1382029#ent", "<e2>", "EC", "4.6.1.1", "."], "h": {"id": "C1137703", "name": "C1137703#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [14, 15]}}
{"token": ["The", "type", "9", "adenylyl", "cyclase", "C1137703#ent", "<e1>", ")", "is", "a", "widely", "distributed", "C1382029#ent", "<e2>", "was", "originally", "cloned", "from", "a", "mouse", "cDNA", "library"], "h": {"id": "C1137703", "name": "C1137703#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [12, 13]}}
{"token": ["The", "C1137703#ent", "<e1>", "AC9", ")", "is", "a", "widely", "distributed", "C1382029#ent", "<e2>", "was", "originally", "cloned", "from", "a", "mouse", "cDNA", "library"], "h": {"id": "C1137703", "name": "C1137703#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [9, 10]}}
{"token": ["When", "saliva", "was", "treated", "with", "neuraminidase", "and", "C1947941#ent", "<e1>", ",", "and", "also", "when", "P.", "aeruginosa", "cells", "were", "treated", "with", "C0017083#ent", "<e2>", ",", "there", "was", "a", "decrease", "in", "aggregating", "activities"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017083", "name": "C0017083#ent", "pos": [19, 20]}}
{"token": ["To", "investigate", "the", "role", "of", "the", "LPTS", "gene", "zebrafish", ",", "we", "cloned", "the", "C1512488#ent", "<e1>", "zLPTS", ",", "which", "encodes", "a", "protein", "of", "355", "C3539947#ent", "<e2>"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [23, 24]}}
{"token": ["We", "trained", "ADX", "and", "control", "rats", "a", "moving", ",", "hidden", "platform", "version", "of", "the", "Morris", "water", "task", "before", "chronic", "administration", "6", "weeks", ")", "of", "C1413627#ent", "<e1>", "and", "either", "C0016365#ent", "<e2>", "or", "vehicle", "."], "h": {"id": "C1413627", "name": "C1413627#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [28, 29]}}
{"token": ["Moraxella", "bovis", "the", "causative", "agent", "infectious", "bovine", "keratoconjunctivitis", "IBK", ")", "also", "known", "as", "C1313983#ent", "<e1>", ",", "a", "highly", "contagious", "and", "C0015397#ent", "<e2>", "is", "common", "in", "cattle", "throughout", "the", "world", "."], "h": {"id": "C1313983", "name": "C1313983#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [20, 21]}}
{"token": ["The", "decrease", "in", "Stat3", "activity", "correlated", "with", "reduced", "C0669372#ent", "<e1>", "proliferation", "and", "a", "positive", "antiapoptotic", "balance", "infiltrating", "inflammatory", "cells", "are", "known", "C0127400#ent", "<e2>", "of", "cell", "damage", "HCV", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [21, 22]}}
{"token": ["The", "relative", "labeling", "rates", "for", "the", "acetylated", "histones", "in", "order", "of", "decreasing", "incorporation", ";", "H3.2", "greater", "than", "C1415432#ent", "<e1>", "greater", "than", "H4", "greater", "than", "H2B.1", "greater", "than", "C3814451#ent", "<e2>", "."], "h": {"id": "C1415432", "name": "C1415432#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3814451", "name": "C3814451#ent", "pos": [27, 28]}}
{"token": ["A", "survey", "of", "serum", "samples", "from", "a", "rabbit", "model", "of", "C0020097#ent", "<e1>", "that", "all", "had", "antibodies", "against", "keratin", "and", "C1420709#ent", "<e2>", "."], "h": {"id": "C0020097", "name": "C0020097#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [19, 20]}}
{"token": ["These", "results", "indicate", "that", "C1419142#ent", "<e1>", "is", "involved", "in", "the", "localization", "of", "C1416471#ent", "<e2>", "at", "AJs", "through", "the", "actin", "cytoskeleton"], "h": {"id": "C1419142", "name": "C1419142#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416471", "name": "C1416471#ent", "pos": [12, 13]}}
{"token": ["Of", "those", "patients", "with", "C0410808#ent", "<e1>", "6", "had", "preexisting", "osteoarthritis", "and", "3", "had", "C0038013#ent", "<e2>", "only", "one", "patient", "with", "native", "joint", "infection", "a", "recognized", "(", "although", "unspecified", ")", ",", "preexisting", "joint", "abnormality"], "h": {"id": "C0410808", "name": "C0410808#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "identify", "a", "cellular", "pathway", "of", "a", "CCSP-binding", "protein", "(", "cubilin", ")", "and", "an", "C3537377#ent", "<e1>", "megalin", ")", "responsible", "for", "C1420295#ent", "<e2>", "uptake", "of", "CCSP", "and", "associated", "ligands"], "h": {"id": "C3537377", "name": "C3537377#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [21, 22]}}
{"token": ["E2", "increased", "apo-VLDL-II", "to", "similar", "levels", "in", "all", "groups", "and", "reduced", "C1334332#ent", "<e1>", "activity", "in", "plasma", "and", "C1418544#ent", "<e2>", "of", "obese", "hens", "."], "h": {"id": "C1334332", "name": "C1334332#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418544", "name": "C1418544#ent", "pos": [17, 18]}}
{"token": ["These", "data", "suggest", "that", "GSTM1", "gene", "and", "C0059735#ent", "<e1>", "increase", "the", "risk", "for", "C0023896#ent", "<e2>"], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023896", "name": "C0023896#ent", "pos": [13, 14]}}
{"token": ["Captopril", "significantly", "decreased", "C1705296#ent", "<e1>", ",", "increased", "RBF", "and", "decreased", "C1417822#ent", "<e2>", "in", "untreated", "dogs", "."], "h": {"id": "C1705296", "name": "C1705296#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417822", "name": "C1417822#ent", "pos": [10, 11]}}
{"token": ["Pretreatment", "with", "the", "microsomal", "oxidase", "inhibitor", "C0618948#ent", "<e1>", "(", "see", "Methods", ")", "prevented", "these", "behavioral", "effects", "of", "C0044647#ent", "<e2>", "and", "blocked", "the", "formation", "of", "NPA", "in", "vitro"], "h": {"id": "C0618948", "name": "C0618948#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0044647", "name": "C0044647#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "C0733398#ent", "<e1>", "could", "be", "a", "valid", "alternative", "to", "verapamil", "as", "a", "C0037766#ent", "<e2>"], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037766", "name": "C0037766#ent", "pos": [13, 14]}}
{"token": ["Two", "transgenic", "potato", "lines", "C1416400#ent", "<e1>", "and", "T2", ",", "expressing", "the", "trehalose-6-phosphate", "synthase", "C1412687#ent", "<e2>", ")", "gene", "of", "yeast", "were", "isolated", "."], "h": {"id": "C1416400", "name": "C1416400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412687", "name": "C1412687#ent", "pos": [13, 14]}}
{"token": ["We", "have", "investigated", "signaling", "pathways", "to", "angiotensin", "II", "C3273406#ent", "<e1>", "activation", "of", "C0170168#ent", "<e2>", "MAPK", ")", "in", "hepatocytes", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [12, 13]}}
{"token": ["C3273406#ent", "<e1>", "at", "least", "via", "its", "type", "1", "receptor", "effect", ",", "phosphorylates", "C0170168#ent", "<e2>", "ERK", ")", "by", "transactivation", "of", "epidermal", "growth", "factor", "receptors", "EGF-Rs", ")", "via", "the", "Ca2", "+", "or", "protein", "kinase", "C", "PKC", ")", "pathways", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [12, 13]}}
{"token": ["It", "has", "earlier", "been", "shown", "that", "the", "isoenzymes", "CYP2D6", "and", "C3714798#ent", "<e1>", "are", "involved", "in", "O-", "and", "N-demethylation", "of", "C0282138#ent", "<e2>", "(", "DTZ", ")", ",", "respectively", "."], "h": {"id": "C3714798", "name": "C3714798#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [19, 20]}}
{"token": ["The", "pharmacokinetic", "interaction", "between", "sirolimus", ",", "a", "macrolide", "immunosuppressant", "metabolized", "by", "C3714798#ent", "<e1>", ",", "and", "the", "calcium", "channel", "blocker", "C0282138#ent", "<e2>", "was", "studied", "in", "18", "healthy", "subjects"], "h": {"id": "C3714798", "name": "C3714798#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [19, 20]}}
{"token": ["At", "8", "X", "10(-5", ")", "M", ",", "C0054259#ent", "<e1>", ",", "oxiconazole", ",", "and", "C0075503#ent", "<e2>", "were", "strictly", "fungistatic", "against", "early", "stationary", "phase", "Candida", "albicans", "cells", "diluted", "into", "fresh", "medium"], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0075503", "name": "C0075503#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "show", "that", "another", "component", "of", "this", "complex", ",", "C1708000#ent", "<e1>", ",", "is", "mutant", "in", "individuals", "with", "Fanconi", "anemia", "a", "new", "C0004135#ent", "<e2>", "FA-M", ")", "."], "h": {"id": "C1708000", "name": "C1708000#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [22, 23]}}
{"token": ["Inhibition", "of", "DNA", "synthesis", "1", "mM", "thymidine", "protects", "cells", "from", "6-mercaptopurine", "or", "C0039902#ent", "<e1>", "but", "fails", "to", "protect", "cells", "from", "C0004476#ent", "<e2>", "toxicity", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004476", "name": "C0004476#ent", "pos": [20, 21]}}
{"token": ["The", "adenoviral", "DNA", "binding", "protein", "C1415740#ent", "<e1>", ")", "is", "a", "C0536221#ent", "<e2>", "in", "DNA", "replication", "gene", "expression"], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [10, 11]}}
{"token": ["The", "order", "of", "C0042402#ent", "<e1>", "potency", "of", "these", "C0035064#ent", "<e2>", "was", ":", "NECA", "greater", "than", "CGS", "21680C", "greater", "than", "adenosine", "greater", "than", "R-PIA", "greater", "than", "S-PIA", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [8, 9]}}
{"token": ["Recovery", "from", "potent", "non-depolarising", "muscle", "C0042402#ent", "<e1>", "is", "slower", "than", "from", "the", "less", "potent", "C0035064#ent", "<e2>", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "mutations", "of", "C1420044#ent", "<e1>", "have", "been", "found", "to", "be", "associated", "with", "C0282102#ent", "<e2>", "humans", "."], "h": {"id": "C1420044", "name": "C1420044#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282102", "name": "C0282102#ent", "pos": [13, 14]}}
{"token": ["Using", "the", "transglycosylation", "reaction", "testicular", "hyaluronidase", "reconstructions", "of", "hybrid", "glycosaminoglycans", "GAGs", ")", "containing", "6-sulfated", "(", "C1414950#ent", "<e1>", ")", ",", "4-sulfated", "(", "GalNAcS", ")", "and", "unsulfated", "N-acetylgalactosamine", "C1825858#ent", "<e2>", ")", "were", "investigated", "."], "h": {"id": "C1414950", "name": "C1414950#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1825858", "name": "C1825858#ent", "pos": [26, 27]}}
{"token": ["After", "control", "measurements", "perfusion", "with", "a", "C0064411#ent", "<e1>", "depleted", "of", "C2936886#ent", "<e2>", "(", "0", "Ca2", "+", ")", "was", "started", "while", "the", "fibers", "were", "continuously", "stimulated", "(", "4", "times/min", ")", "and", "twitches", "recorded", "."], "h": {"id": "C0064411", "name": "C0064411#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [10, 11]}}
{"token": ["Patients", "with", "C0039445#ent", "<e1>", "at", "risk", "for", "the", "development", "of", "C0000833#ent", "<e2>"], "h": {"id": "C0039445", "name": "C0039445#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [10, 11]}}
{"token": ["Both", "vinculin", "and", "C1420760#ent", "<e1>", "concentrations", "increased", "with", "prolonged", "C0078956#ent", "<e2>", "treatment", "."], "h": {"id": "C1420760", "name": "C1420760#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [9, 10]}}
{"token": ["The", "effect", "of", "a", "mixture", "of", "nitroblue", "tetrazolium", "NBT", ")", "and", "vitamin", "E", "the", "metabolism", "and", "ultrastructure", "of", "C0064833#ent", "<e1>", "PMN", ")", "from", "normal", "subjects", "patients", "with", "chronic", "granulomatous", "disease", "C3811755#ent", "<e2>", ")", "was", "determined", "in", "vitro"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3811755", "name": "C3811755#ent", "pos": [30, 31]}}
{"token": ["It", "can", "be", "concluded", "that", "the", "MR", "formulation", "carbonyl", "iron", "more", "efficacious", "than", "C0060276#ent", "<e1>", "correcting", "haematologic", "abnormalities", "improving", "iron", "status", "patients", "with", "C0162316#ent", "<e2>"], "h": {"id": "C0060276", "name": "C0060276#ent", "pos": [13, 14]}, "relation": "may_prevent", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [23, 24]}}
{"token": ["The", "yield", "of", "amplification", "performed", "at", "optimum", "MgCl2", "concentration", "for", "the", "C0075813#ent", "<e1>", "or", "the", "S.", "acidocaldarius", "C0012892#ent", "<e2>", "for", "the", "same", "DNA", "target", "was", "equivalent", "."], "h": {"id": "C0075813", "name": "C0075813#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [17, 18]}}
{"token": ["In", "an", "attempt", "to", "find", "a", "thermostable", "DNA", "polymerase", "resistant", "than", "C0075813#ent", "<e1>", "to", "PCR", "inhibitors", "present", "in", "chicken", "samples", "three", "C0012892#ent", "<e2>", "evaluated", "."], "h": {"id": "C0075813", "name": "C0075813#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [21, 22]}}
{"token": ["Compared", "with", "wild-type", "C1705526#ent", "<e1>", ",", "the", "hot-spot", "C1705526#ent", "<e1>", "mutants", "showed", "increased", "binding", "to", "C1136197#ent", "<e1>", ",", "which", "can", "explain", "their", "resistance", "to", "dicoumarol-induced", "degradation", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [15, 16]}}
{"token": ["Cytochrome", "b5", "not", "enhance", "the", "P-450ac-catalyzed", "metabolism", "of", "other", "drug", "substrates", "as", "C0005096#ent", "<e1>", ",", "aminopyrine", ",", "and", "C0009214#ent", "<e2>", "."], "h": {"id": "C0005096", "name": "C0005096#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009214", "name": "C0009214#ent", "pos": [18, 19]}}
{"token": ["Traditional", "slower", "acting", "C0003191#ent", "<e1>", "such", "as", "gold", "therapy", "penicillamine", ",", "sulfasalazine", ",", "tiopronin", "and", "C0020336#ent", "<e2>", ",", "are", "usually", "poorly", "active", "in", "children", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [15, 16]}}
{"token": ["Older", "disease", "C0003191#ent", "<e1>", "DMARDs", ")", "include", "methotrexate", ",", "sulphasalazine", "and", "C0020336#ent", "<e2>", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [11, 12]}}
{"token": ["We", "also", "overexpressed", "this", "protein", "in", "transgenic", "flies", "a", "variety", "of", "developmental", "and", "tissue-specific", "patterns", "to", "examine", "the", "effects", "of", "C2712370#ent", "<e1>", "the", "concentration", "of", "this", "C1421652#ent", "<e2>", "in", "vivo"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1421652", "name": "C1421652#ent", "pos": [26, 27]}}
{"token": ["740Y-P", "C0030956#ent", "<e1>", ",", "a", "direct", "activator", "of", "C0044602#ent", "<e2>", "stimulated", "PGC", "migration", "at", "levels", "similar", "to", "those", "elicited", "by", "KL", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [8, 9]}}
{"token": ["Muscle", "insulin", "binding", "and", "C0030956#ent", "<e1>", "contents", "of", "insulin", "receptor", "IRS-1", ",", "p85", "subunit", "C0044602#ent", "<e2>", ",", "Akt/PKB", ",", "and", "atypical", "PKC", "isoform", "zeta", "were", "not", "different", "between", "EtOH-exposed", "rats", "and", "controls", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [14, 15]}}
{"token": ["Ammonia", "may", "be", "the", "major", "cerebral", "intoxicant", "responsible", "for", "the", "increased", "general", "or", "passive", "permeability", "of", "the", "blood-brain", "barrier", "C1801950#ent", "<e1>", ")", "leading", "to", "the", "cerebral", "edema", "associated", "with", "C0162557#ent", "<e2>"], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [29, 30]}}
{"token": ["This", "would", "appear", "that", "PGE2", "is", "acting", "directly", "on", "the", "Blood", "Bain", "Barrier", "C1801950#ent", "<e1>", ")", "to", "preserve", "it", "despite", "progressive", "C0162557#ent", "<e2>"], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [21, 22]}}
{"token": ["The", "mammalian", "genome", "contains", "two", "C1417544#ent", "<e1>", ",", "two", "smooth", "muscle", "and", "eight", "striated", "muscle", "isoforms", "C1417537#ent", "<e2>", "."], "h": {"id": "C1417544", "name": "C1417544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417537", "name": "C1417537#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "these", "sites", ",", "we", "examined", "the", "electron", "microscopic", "dual-immunolabeling", "of", "C1418447#ent", "<e1>", "and", "D1R", "or", "tyrosine", "hydroxylase", "C4285344#ent", "<e2>", ")", ",", "a", "marker", "of", "catecholamine", "terminals", "the", "rat", "Acb", "shell", "."], "h": {"id": "C1418447", "name": "C1418447#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4285344", "name": "C4285344#ent", "pos": [19, 20]}}
{"token": ["C2698689#ent", "<e1>", "is", "a", "C0031686#ent", "<e2>", "containing", "a", "Ser-104", "phosphorylated", "by", "protein", "kinase", "C", "a", "Ser-116", "phosphorylated", "by", "CamKII", "(", "calcium/calmodulin-dependent", "protein", "kinase", "II", "or", "AKT", "."], "h": {"id": "C2698689", "name": "C2698689#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [4, 5]}}
{"token": ["Also", ",", "DNA", "ligase", "II", "use", "ATP", "alpha", "S", "as", "a", "cofactor", "in", "the", "ligation", "reaction", "more", "efficiently", "than", "C1416851#ent", "<e1>", "further", "discriminating", "the", "ATP", "binding", "sites", "of", "these", "C3541394#ent", "<e2>", "."], "h": {"id": "C1416851", "name": "C1416851#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [29, 30]}}
{"token": ["Induction", "of", "epidermal", "C0029282#ent", "<e1>", "activity", "was", "inhibited", "by", "arotinoid", "ethyl", "ester", "not", "by", "RA", ",", "C0022265#ent", "<e2>", ",", "or", "aromatic", "retinoid", "they", "were", "applied", "to", "the", "skin", "at", "24", "hr", "prior", "to", "tape", "stripping"], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [3, 4]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [16, 17]}}
{"token": ["Both", "TPA-dependent", "and", "developmental", "increases", "in", "mouse", "brain", "C0029282#ent", "<e1>", "activity", "were", "significantly", "reduced", "by", "intracisternal", "injection", "of", "C0022265#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [8, 9]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "C0079975#ent", "<e1>", "were", "not", "coincident", "with", "reduced", "C0694888#ent", "<e2>", "expression", ",", "and", "the", "concurrent", "mutation", "of", "C0079975#ent", "<e1>", "and", "BRAF", "was", "rare", "."], "h": {"id": "C0079975", "name": "C0079975#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0694888", "name": "C0694888#ent", "pos": [9, 10]}}
{"token": ["Several", "aldosterone-sensitive", "genes", ",", "including", "serum", "and", "glucocorticoid-inducible", "kinase", "C1420010#ent", "<e1>", ")", "and", "small", ",", "C0220304#ent", "<e2>", "Ki-ras", ")", "have", "recently", "been", "identified", "."], "h": {"id": "C1420010", "name": "C1420010#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220304", "name": "C0220304#ent", "pos": [15, 16]}}
{"token": ["In", "the", "second", "group", ",", "C0036572#ent", "<e1>", "afterdischarge", "duration", "were", "not", "affected", "by", "C0031978#ent", "<e2>", "in", "fully-kindled", "animals", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [13, 14]}}
{"token": ["At", "the", "same", "time", "C1868684#ent", "<e1>", "from", "the", "cornea", "(", "the", "C0599295#ent", "<e2>", ")", "and", "frontal", "sinus", "recorded", "differentially", "against", "the", "neck", "muscle", "electrode"], "h": {"id": "C1868684", "name": "C1868684#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [11, 12]}}
{"token": ["Quantification", "of", "C0051767#ent", "<e1>", ",", "DON", ",", "and", "T-2", "and", "of", "C3273654#ent", "<e2>", "were", "achieved", "by", "gas", "chromatography", "high", "performance", "liquid", "chromatography", "respectively", "."], "h": {"id": "C0051767", "name": "C0051767#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273654", "name": "C3273654#ent", "pos": [11, 12]}}
{"token": ["Kin28", "and", "Srb10", "also", "have", "overlapping", "roles", "in", "promoting", "C0101555#ent", "<e1>", "dissociation", "of", "the", "preinitiation", "complex", "C0730321#ent", "<e2>", ")", "into", "the", "Scaffold", "complex"], "h": {"id": "C0101555", "name": "C0101555#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0730321", "name": "C0730321#ent", "pos": [16, 17]}}
{"token": ["The", "following", "relationships", "were", "found", "to", "be", "significant", ":", "Headaches", "and", "lateral", "pterygoid", "muscle", "tenderness", "Earache", "and", "medial", "pterygoid", "muscle", "tenderness", "Neck", "pain", "one", "or", "more", "C0240419#ent", "<e1>", "C0577887#ent", "<e2>", "one", "or", "more", "C0240419#ent", "<e1>", "C0577887#ent", "<e2>", "temporal", "muscle", "tenderness", "C0577887#ent", "<e2>", "medial", "pterygoid", "muscle", "tenderness"], "h": {"id": "C0577887", "name": "C0577887#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0240419", "name": "C0240419#ent", "pos": [26, 27]}}
{"token": ["In", "addition", ",", "C3891070#ent", "<e1>", "elevated", "apoptotic", "sensitivity", "tumor", "cells", "genotoxic", "agents", "such", "as", "5-FU", ",", "C0015133#ent", "<e2>", "and", "ultraviolet", "."], "h": {"id": "C3891070", "name": "C3891070#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [16, 17]}}
{"token": ["The", "first", "BMT", "cured", "XSCID", "and", "the", "second", "BMT", "cured", "a", "complicating", "C0002874#ent", "<e1>", "BMT", "as", "a", "treatment", "of", "many", "C0029896#ent", "<e2>", "."], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [20, 21]}}
{"token": ["Although", "C0002874#ent", "<e1>", "not", "increased", "as", "a", "late", "effect", "the", "atomic", "bomb", "exposure", ",", "many", "atypical", "leukemia", "other", "myeloproliferative", "diseases", "had", "been", "diagnosed", "as", "C0002874#ent", "<e1>", "its", "related", "C0029896#ent", "<e1>", "have", "been", "experienced", "among", "atomic", "bomb", "survivors", "."], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [28, 29]}}
{"token": ["Canavan", "disease", "an", "inherited", "C0023520#ent", "<e1>", ",", "is", "caused", "by", "mutations", "in", "the", "aspartoacylase", "(", "C3274916#ent", "<e2>", ")", "gene", "."], "h": {"id": "C0023520", "name": "C0023520#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3274916", "name": "C3274916#ent", "pos": [15, 16]}}
{"token": ["Subsequent", "treatment", "with", "C0014994#ent", "<e1>", "to", "remove", "any", "surface", "species", "but", "instead", "the", "C0014994#ent", "<e1>", "becomes", "strongly", "associated", "with", "surface", "and", "highly", "resistant", "to", "removal", "."], "h": {"id": "C0014994", "name": "C0014994#ent", "pos": [3, 4]}, "relation": "product_component_of", "t": {"id": "C0014994", "name": "C0014994#ent", "pos": [3, 4]}}
{"token": ["Progressive", "C0015468#ent", "<e1>", "accompanied", "by", "oculosympathetic", "paresis", "altered", "taste", ",", "and", "C0028643#ent", "<e2>", "the", "possibility", "of", "basal", "skull", "neoplasm"], "h": {"id": "C0015468", "name": "C0015468#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0028643", "name": "C0028643#ent", "pos": [11, 12]}}
{"token": ["The", "C1412365#ent", "<e1>", "pattern", "of", "C0019484#ent", "<e2>", "in", "Niemann-Pick", "mice", "similar", "to", "that", "of", "control", "enzymes"], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019484", "name": "C0019484#ent", "pos": [5, 6]}}
{"token": ["The", "activity", "and", "C1412365#ent", "<e1>", "patterns", "of", "C0019484#ent", "<e2>", "in", "human", "renal", "carcinoma", "studied", "in", "comparison", "with", "those", "of", "normal", "kidney"], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019484", "name": "C0019484#ent", "pos": [7, 8]}}
{"token": ["GPR48", ",", "also", "known", "as", "leucine-rich", "repeat", "(LRR)-containing", "G-protein-coupled", "receptor", "4", "C1537569#ent", "<e1>", ")", ",", "is", "a", "member", "of", "the", "G-protein-coupled", "receptor", "C1428424#ent", "<e2>", ")", "family", "of", "proteins", "."], "h": {"id": "C1537569", "name": "C1537569#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1428424", "name": "C1428424#ent", "pos": [22, 23]}}
{"token": ["In", "view", "of", "the", "fact", "that", "genes", "for", "hereditary", "spastic", "paraplegia", "produce", "highly", "variable", "phenotypes", ",", "the", "eight", "known", "C2936739#ent", "<e1>", "investigated", "for", "linkage", "to", "C0175693#ent", "<e2>"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0175693", "name": "C0175693#ent", "pos": [25, 26]}}
{"token": ["Trichophyton", "rubrum", "the", "predominant", "species", "in", "all", "anatomical", "sites", "excluding", "C0240940#ent", "<e1>", ",", "followed", "by", "Microsporum", "canis", "the", "leading", "agent", "of", "C0040250#ent", "<e2>"], "h": {"id": "C0240940", "name": "C0240940#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040250", "name": "C0040250#ent", "pos": [21, 22]}}
{"token": ["Mutations", "in", "the", "C0079429#ent", "<e1>", "encoding", "for", "the", "C1414998#ent", "<e2>", "GBA", ")", "result", "in", "Gaucher", "disease"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414998", "name": "C1414998#ent", "pos": [8, 9]}}
{"token": ["This", "conclusion", "was", "supported", "by", "measurements", "of", "sugar", "phosphates", "which", "showed", "that", "there", "were", "increased", "concentrations", "of", "C0017755#ent", "<e1>", ",", "galactose-6-phosphate", ",", "and", "fructose-6-phosphate", "in", "the", "strain", "construct", "overexpressing", "C1418517#ent", "<e2>", "."], "h": {"id": "C0017755", "name": "C0017755#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418517", "name": "C1418517#ent", "pos": [29, 30]}}
{"token": ["In", "senescent", "endothelial", "cells", "PAI-1", "mRNA", "and", "protein", "are", "C0907533#ent", "<e1>", "high", ",", "but", "uninducible", "by", "exogenous", "C1334111#ent", "<e2>", "well", "as", "by", "the", "phorbol", "ester", "TPA", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334111", "name": "C1334111#ent", "pos": [17, 18]}}
{"token": ["In", "vitro", "TNF-alpha", "was", "not", "expressed", "C0907533#ent", "<e1>", "in", "the", "follicle", "cells", "incubating", "them", "with", "C1334111#ent", "<e2>", "in", "a", "strong", "expression", "of", "TNF-alpha", "after", "only", "0.5h", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334111", "name": "C1334111#ent", "pos": [15, 16]}}
{"token": ["The", "syntheses", "of", "ICP4", ",", "a", "C3493756#ent", "<e1>", "and", "ICP8", ",", "a", "C0078939#ent", "<e2>", ",", "were", "not", "generally", "reduced", "by", "noncytotoxic", "concentrations", "of", "snuff", "extract", "(", "where", "ICP", "=", "infected", "cell", "polypeptide", "."], "h": {"id": "C3493756", "name": "C3493756#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [12, 13]}}
{"token": ["Consumption", "of", "C1257966#ent", "<e1>", "shown", "to", "preserve", "paraoxonase", "activity", "reducing", "the", "oxidative", "stress", "C1704299#ent", "<e2>", "thereby", "contributing", "to", "paraoxonase", "hydrolytic", "activity", "lipid", "peroxides", "oxidized", "lipoproteins", "atherosclerotic", "lesions"], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704299", "name": "C1704299#ent", "pos": [13, 14]}}
{"token": ["Dietary", "supplements", "C0033798#ent", "<e1>", "and", "other", "C0949738#ent", "<e2>", "related", "to", "C0033798#ent", "<e1>", "are", "largely", "consumed", "in", "various", "countries", ",", "with", "the", "purpose", "of", "energetic", "stimulation", "and", "weight", "loss"], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [2, 3]}}
{"token": ["The", "rank", "order", "of", "potencies", "of", "C0949738#ent", "<e1>", "containing", "a", "1R,2S-configuration", "was", "norephedrine", ">", "or", "=", "C0033798#ent", "<e2>", ">", ">"], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [16, 17]}}
{"token": ["The", "contents", "of", "C0949738#ent", "<e1>", "higher", "and", "C0033798#ent", "<e2>", "is", "the", "main", "component", "in", "samples", "derived", "from", "Ephedra", "sinica", "E.", "equisetina", ",", "E.", "monosperma", "and", "E.", "intermedia", "var", "."], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [7, 8]}}
{"token": ["C1852406#ent", "<e1>", "characterized", "by", "cutis", "gyrata", "acanthosis", "nigricans", "skin", "furrows", "skin", "tags", "C0010278#ent", "<e2>", ",", "Crouzonoid-like", "features", "in", "some", "cases", "and", "cloverleaf", "skull", "others", ",", "anogenital", "anomalies", "and", "prominent", "umbilical", "stump", "."], "h": {"id": "C1852406", "name": "C1852406#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [12, 13]}}
{"token": ["On", "the", "basis", "of", "the", "provisional", "clinical", "diagnosis", "C1413193#ent", "<e1>", "was", "more", "frequently", "requested", "for", "probable", "structural", "changes", "and", "C0392475#ent", "<e2>", "for", "probable", "perfusion", "abnormalities"], "h": {"id": "C1413193", "name": "C1413193#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0392475", "name": "C0392475#ent", "pos": [19, 20]}}
{"token": ["We", "have", "identified", "a", "large", "cohort", "of", "Korean", "cis-AB", "blood", "donors", "studied", "the", "N-acetylgalactosaminyltransferase", "(", "C1333828#ent", "<e1>", "GTA", ")", "and", "C0016964#ent", "<e2>", "(", "glycosyltransferase", "B", "GTB", ")", "activity", "of", "their", "cis-AB", "serum", "enzymes", "."], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [20, 21]}}
{"token": ["In", "this", "report", ",", "we", "describe", "the", "cloning", "and", "characterization", "of", "the", "GC", "gene", "C1333828#ent", "<e1>", "pgtA", ")", ",", "which", "encodes", "the", "C0016964#ent", "<e2>", "catalyzes", "the", "synthesis", "of", "this", "Gal-GlcNAc", "bond", "of", "pilin", "glycan"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0016964", "name": "C0016964#ent", "pos": [22, 23]}}
{"token": ["C2936331#ent", "<e1>", "(", "SGpathies", ")", "are", "highly", "frequent", "among", "severely", "affected", "C0686353#ent", "<e2>", "patients", "."], "h": {"id": "C2936331", "name": "C2936331#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "a", "case", "of", "a", "29-year-old", "Caucasian", "woman", "who", "developed", "a", "C0234533#ent", "<e1>", "sudden", "C0078839#ent", "<e2>", "withdrawal", "subsequent", "to", "drug", "dependence", "160", "mg", "of", "C0078839#ent", "<e2>", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0078839", "name": "C0078839#ent", "pos": [15, 16]}}
{"token": ["BALF", "from", "C0878555#ent", "<e1>", "patients", "contained", "a", "higher", "concentration", "of", "C0887942#ent", "<e2>", "than", "those", "from", "patients", "with", "idiopathic", "pulmonary", "fibrosis", "healthy", "volunteers"], "h": {"id": "C0878555", "name": "C0878555#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0887942", "name": "C0887942#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "indicate", "accumulation", "of", "neutrophil-derived", "defensins", "in", "the", "airway", "in", "C0878555#ent", "<e1>", "and", "suggest", "that", "C0887942#ent", "<e2>", "may", "be", "a", "marker", "of", "neutrophil", "activity", "this", "disease", "."], "h": {"id": "C0878555", "name": "C0878555#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0887942", "name": "C0887942#ent", "pos": [16, 17]}}
{"token": ["The", "non-nucleoside", "reverse", "transcriptase", "inhibitor", "delavirdine", "potently", "inhibits", "C1142644#ent", "<e1>", ",", "whereas", "C0132326#ent", "<e2>", "and", "efavirenz", "are", "inducers", "of", "C1142644#ent", "<e1>", "."], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [12, 13]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [8, 9]}}
{"token": ["Delaviridine", "is", "an", "inhibitor", "of", "C1142644#ent", "<e1>", ",", "but", "C0132326#ent", "<e2>", "and", "efavirenz", "are", "inducers", "of", "C1142644#ent", "<e1>", "."], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [9, 10]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [5, 6]}}
{"token": ["Collectively", ",", "these", "data", "indicate", "that", "C0132326#ent", "<e1>", "is", "principally", "metabolized", "by", "C1142644#ent", "<e2>", "and", "CYP2B6", "and", "that", "it", "has", "little", "potential", "to", "be", "involved", "in", "inhibitory", "drug", "interactions"], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}}
{"token": ["From", "this", "cluster", ",", "we", "identified", "Insm1", "and", "Nhlh1/NSCL1", "as", "novel", "C0392514#ent", "<e1>", "targets", "induced", "by", "C1335824#ent", "<e2>", "treatment", "in", "cultured", "cerebellar", "granule", "cell", "progenitors", "."], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335824", "name": "C1335824#ent", "pos": [16, 17]}}
{"token": ["Three", "C0392514#ent", "<e1>", "homologs", "have", "been", "identified", "in", "humans", "including", "Sonic", "hedgehog", "C1335824#ent", "<e2>", ")", ",", "Indian", "hedgehog", "IHH", ")", "and", "Desert", "hedgehog", "DHH", ")", "."], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335824", "name": "C1335824#ent", "pos": [12, 13]}}
{"token": ["These", "C0026457#ent", "<e1>", "were", "identified", "by", "high-resolution", "mass", "spectrometry", "as", "C1257968#ent", "<e2>", "and", "isorhamnetin", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1257968", "name": "C1257968#ent", "pos": [10, 11]}}
{"token": ["Parents", "assisted", "patients", "in", "C1457887#ent", "<e1>", "(", "sneezing", ",", "nasal", "discharge", "itchy", "eyes", "itchy", "nose", "mouth", ",", "C0009763#ent", "<e2>", ",", "nasal", "congestion", "daily", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [17, 18]}}
{"token": ["Consistent", "with", "data", "in", "the", "literature", "it", "was", "possible", "from", "the", "C3813556#ent", "<e1>", "to", "differentiate", "C0026848#ent", "<e2>", "neurogenic", "ones"], "h": {"id": "C3813556", "name": "C3813556#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [15, 16]}}
{"token": ["Four", "of", "them", "were", "the", "product", "of", "a", "C0085207#ent", "<e1>", "or", "preserved", "by", "gonadotropins", ",", "C0546859#ent", "<e2>", "or", "progestational", "hormones"], "h": {"id": "C0085207", "name": "C0085207#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0546859", "name": "C0546859#ent", "pos": [15, 16]}}
{"token": ["The", "interaction", "of", "two", "orally", "administered", "Ca-channel", "blockers", "the", "C0012315#ent", "<e1>", "nisoldipine", "and", "nifedipine", ",", "with", "the", "non-depolarizing", "muscle", "relaxant", ",", "C0242531#ent", "<e2>", "was", "tested", "in", "the", "indirectly", "stimulated", "tibialis", "anterior", "muscle", "anesthetized", "and", "ventilated", "Sprague-Dawley", "rats"], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242531", "name": "C0242531#ent", "pos": [21, 22]}}
{"token": ["To", "compare", "the", "efficacy", "of", "C0673966#ent", "<e1>", "in", "Japanese", "patients", "with", "C0017612#ent", "<e2>", "POAG", ")", "or", "ocular", "hypertension", "OH", ")", "after", "a", "change", "from", "timolol", "in", "combination", "therapy", "latanoprost", "."], "h": {"id": "C0673966", "name": "C0673966#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [11, 12]}}
{"token": ["To", "assess", "the", "effects", "of", "C0673966#ent", "<e1>", "and", "dorzolamide", "on", "ocular", "haemodynamics", "retinal", "oxygen", "saturation", "patients", "with", "C0017612#ent", "<e2>", "OAG", ")", "."], "h": {"id": "C0673966", "name": "C0673966#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [17, 18]}}
{"token": ["C0673966#ent", "<e1>", "has", "been", "introduced", "to", "treat", "ocular", "hypertension", "C0017612#ent", "<e2>"], "h": {"id": "C0673966", "name": "C0673966#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [9, 10]}}
{"token": ["Huntington's", "disease", "HD", ")", "is", "a", "C0524851#ent", "<e1>", "by", "polyglutamine", "(", "polyQ", ")", "expansion", "in", "the", "protein", "huntingtin", "C3814032#ent", "<e2>", ")", "."], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3814032", "name": "C3814032#ent", "pos": [18, 19]}}
{"token": ["We", "now", "report", "a", "new", "specificity", ",", "antibodies", "to", "lipoprotein", "lipase", "C0023816#ent", "<e1>", ")", "that", "is", "strongly", "associated", "with", "C4053959#ent", "<e2>", "has", "a", "powerful", "synergistic", "effect", "anti-ribosomal", "P", "antibodies", "its", "association", "with", "nephritis", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [19, 20]}}
{"token": ["We", "now", "report", "a", "new", "specificity", ",", "antibodies", "to", "C0023816#ent", "<e1>", "LPL", ")", "that", "is", "strongly", "associated", "with", "C4053959#ent", "<e2>", "has", "a", "powerful", "synergistic", "effect", "anti-ribosomal", "P", "antibodies", "its", "association", "with", "nephritis", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "case", "of", "C0041325#ent", "<e1>", "a", "patient", "with", "concomitant", "HIV", "infection", "C0023890#ent", "<e2>"], "h": {"id": "C0041325", "name": "C0041325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [13, 14]}}
{"token": ["Animal", "models", "that", "C1565860#ent", "<e1>", "(", "COX-2", ")", "inhibitors", "may", "be", "beneficial", "in", "suppressing", "C1516009#ent", "<e2>"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516009", "name": "C1516009#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "C1565860#ent", "<e1>", "(", "COX-2", ")", "inhibitor", ",", "meloxicam", ",", "on", "tumour", "growth", "C1516009#ent", "<e2>", "have", "been", "determined", "in", "2", "established", "murine", "adenocarcinomas", "MAC", ")", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516009", "name": "C1516009#ent", "pos": [15, 16]}}
{"token": ["Activation", "of", "C3809768#ent", "<e1>", ",", "acid", "appeared", "to", "be", "also", "independent", "of", "intracellular", "C1413043#ent", "<e2>", "+", "and", "G", "protein"], "h": {"id": "C3809768", "name": "C3809768#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [13, 14]}}
{"token": ["Unilateral", "paresis", "after", "C0032371#ent", "<e1>", "may", "affect", "the", "expression", "of", "inflammatory", "diseases", "lateralization", "of", "the", "C0029166#ent", "<e2>"], "h": {"id": "C0032371", "name": "C0032371#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [15, 16]}}
{"token": ["MCG", "classification", "of", "C0559106#ent", "<e1>", "been", "attempted", "in", "70", "patients", "with", "overt", "C0559106#ent", "<e1>", "."], "h": {"id": "C0559106", "name": "C0559106#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0559106", "name": "C0559106#ent", "pos": [3, 4]}}
{"token": ["Waveform", "of", "the", "QRS", "complex", "C0559106#ent", "<e1>", "subject", "to", "the", "influence", "of", "both", "the", "site", "of", "C0559106#ent", "<e1>", "and", "the", "time", "of", "C0559106#ent", "<e1>", "relative", "to", "that", "of", "excitation", "via", "the", "normal", "AV", "path"], "h": {"id": "C0559106", "name": "C0559106#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0559106", "name": "C0559106#ent", "pos": [5, 6]}}
{"token": ["A", "29-year-old", "pregnant", "woman", "in", "the", "32", "weeks", "of", "gestation", "with", "C1414542#ent", "<e1>", "admitted", "to", "our", "hospital", "for", "the", "treatment", "of", "anterior", "chest", "C0024031#ent", "<e2>"], "h": {"id": "C1414542", "name": "C1414542#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [23, 24]}}
{"token": ["Differentiation", "of", "herpes", "simplex", "virus", "HSV", ")", "types", "1", "and", "2", "in", "cerebrospinal", "fluid", "17", "patients", "with", "serologically", "diagnosed", "HSV", "encephalitis", "meningitis", "or", "C0338430#ent", "<e1>", "determined", "by", "stringent", "hybridization", "of", "polymerase", "chain", "reaction", "amplified", "C0011522#ent", "<e2>", "."], "h": {"id": "C0338430", "name": "C0338430#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [34, 35]}}
{"token": ["The", "current", "study", "used", "a", "treatment-seeking", "community", "sample", "C1838244#ent", "<e1>", "symptomatology", "in", "a", "competitive", "C1416596#ent", "<e2>", "designed", "to", "be", "a", "more", "naturalistic", "Fixed", "Time", "task", "."], "h": {"id": "C1838244", "name": "C1838244#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [14, 15]}}
{"token": ["Primary", "and", "recurrent", "visceral", "forms", "C0033741#ent", "<e1>", "been", "treated", "with", "liposomal", "amphotericin", "B", "while", "C0030864#ent", "<e2>", "successfully", "employed", "as", "treatment", "for", "subsequent", "cutaneous", "relapse", "as", "secondary", "prophylaxis"], "h": {"id": "C0033741", "name": "C0033741#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030864", "name": "C0030864#ent", "pos": [14, 15]}}
{"token": ["A", "great", "body", "of", "evidence", "indicates", "that", "C0022806#ent", "<e1>", "early", "in", "life", "induces", "central", "noradrenergic", "hyperactivity", "(", "C4053530#ent", "<e2>", ")", "."], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4053530", "name": "C4053530#ent", "pos": [17, 18]}}
{"token": ["Decreased", "intestinal", "absorption", "of", "C1413043#ent", "<e1>", "+", "occurs", "in", "response", "to", "treatment", "with", "C0086268#ent", "<e2>", "EHDP", ")", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086268", "name": "C0086268#ent", "pos": [13, 14]}}
{"token": ["Immunoblot", "analysis", "a", "significant", "increase", "in", "the", "levels", "of", "phosphorylated", "(P-)CaMKII", "and", "C0256015#ent", "<e1>", "PKCgamma", ")", "in", "C0012694#ent", "<e2>", "from", "OZR", "."], "h": {"id": "C0256015", "name": "C0256015#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [17, 18]}}
{"token": ["To", "study", "the", "morphologic", "classification", "its", "clinical", "significance", "giant", "left", "atrium", "C1425280#ent", "<e1>", ")", "combined", "with", "C0018824#ent", "<e2>"], "h": {"id": "C1425280", "name": "C1425280#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [16, 17]}}
{"token": ["Molecular", "analysis", "FRET", ")", "was", "performed", "on", "selected", "cases", "for", "three", "common", "hereditary", "thrombophilias", "mutations", "in", "C0380964#ent", "<e1>", "FVL", ")", ",", "prothrombin", "G20210A", "PT", ")", ",", "and", "C0066357#ent", "<e2>", "MTHFR", ")", "."], "h": {"id": "C0380964", "name": "C0380964#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0066357", "name": "C0066357#ent", "pos": [27, 28]}}
{"token": ["Immunostained", "C0032002#ent", "<e1>", "S-100", "protein", "antibody", "were", "photographed", "using", "a", "C0751951#ent", "<e2>", "camera", "equipped", "with", "a", "computer", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0751951", "name": "C0751951#ent", "pos": [10, 11]}}
{"token": ["Isoform", "diversity", "arises", "through", "alternative", "RNA", "splicing", "in", "the", "C0002523#ent", "<e1>", "and", "carboxyl", "termini", "the", "C3275243#ent", "<e2>"], "h": {"id": "C0002523", "name": "C0002523#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3275243", "name": "C3275243#ent", "pos": [15, 16]}}
{"token": ["The", "translocation", "fuses", "the", "PML", "gene", "to", "the", "C1366536#ent", "<e1>", "RAR", "alpha", "gene", "resulting", "in", "the", "production", "of", "a", "C1709412#ent", "<e2>"], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [8, 9]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1709412", "name": "C1709412#ent", "pos": [19, 20]}}
{"token": ["The", "t(15;17)", "chromosomal", "translocation", "specific", "for", "acute", "promyelocytic", "leukemia", "APL", ")", ",", "fuses", "the", "PML", "gene", "to", "the", "C1366536#ent", "<e1>", "RAR", "alpha", "gene", ",", "resulting", "in", "expression", "of", "a", "C1709412#ent", "<e2>"], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [18, 19]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1709412", "name": "C1709412#ent", "pos": [29, 30]}}
{"token": ["Transient", "transfection", "experiments", "show", "that", "ATRA", "enhances", "the", "transactivating", "properties", "of", "Stat1", "alpha", "on", "an", "appropriate", "reporter", "gene", "in", "the", "presence", "of", "the", "C1366536#ent", "<e1>", "but", "not", "in", "the", "presence", "of", "the", "C1709412#ent", "<e2>"], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [23, 24]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1709412", "name": "C1709412#ent", "pos": [32, 33]}}
{"token": ["The", "greater", "effectiveness", "of", "methacholine", "than", "phenylisopropyladenosine", "as", "a", "negative", "C0304509#ent", "<e1>", "an", "inhibitor", "of", "C0001492#ent", "<e2>", "atria", "may", "be", "related", "to", "the", "relative", "densities", "of", "muscarinic", "and", "adenosine", "receptors"], "h": {"id": "C0304509", "name": "C0304509#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "adenosine", "should", "have", "no", "effect", "positive", "C0304509#ent", "<e1>", "act", "independently", "of", "C0001492#ent", "<e2>"], "h": {"id": "C0304509", "name": "C0304509#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [13, 14]}}
{"token": ["Histological", "examination", "a", "painless", "solitary", "cutaneous", "in", "the", "otherwise", "asymptomatic", "first", "patient", "showed", "a", "nonspecific", "C1274778#ent", "<e1>", "1", "yr", "later", "a", "definite", "diagnosis", "of", "C0024141#ent", "<e2>", "was", "made", "."], "h": {"id": "C1274778", "name": "C1274778#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [24, 25]}}
{"token": ["In", "this", "preparation", "1", "microM", "glycine", "or", "1", "microM", "C0069772#ent", "<e1>", "prevented", "the", "antagonism", "by", "kynurenate", "of", "the", "C0022614#ent", "<e2>", "or", "the", "glutamate-evoked", "[3H]noradrenaline", "release", "."], "h": {"id": "C0069772", "name": "C0069772#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [18, 19]}}
{"token": ["A", "high", "dose", "C0002144#ent", "<e1>", "(", "100", "mg/kg", ")", "strongly", "attenuated", "C2917659#ent", "<e2>", "protein-adduct", "formation", "and", "prevented", "the", "mitochondrial", "oxidant", "stress", "liver", "injury", "C2917659#ent", "<e2>", "."], "h": {"id": "C0002144", "name": "C0002144#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2917659", "name": "C2917659#ent", "pos": [11, 12]}}
{"token": ["Examination", "of", "population", "data", "of", "healthy", "females", "of", "pedigrees", "of", "ovarian", "cancer", "patients", "suggested", "that", "the", "quantitative", "activity", "C1414857#ent", "<e1>", "in", "serum", "was", "C1516876#ent", "<e2>", "determined", "."], "h": {"id": "C1414857", "name": "C1414857#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [23, 24]}}
{"token": ["Six", "had", "minimal", "change", "C0017658#ent", "<e1>", "and", "two", "had", "C0268744#ent", "<e2>"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0268744", "name": "C0268744#ent", "pos": [9, 10]}}
{"token": ["The", "magnitude", "of", "C1336694#ent", "<e1>", "differed", "with", "the", "different", "FAK", "and", "C1705341#ent", "<e2>", "sites", "."], "h": {"id": "C1336694", "name": "C1336694#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [11, 12]}}
{"token": ["Transfusion", "of", "fresh", "frozen", "plasma", "indicated", "for", "reversal", "of", "inherited", "isolated", "coagulation", "factor", "deficiencies", ",", "emergent", "reversal", "of", "the", "effects", "of", "warfarin", "sodium", "C0265374#ent", "<e1>", ",", "Panwarfin", ",", "Sofarin", ")", ",", "C0272375#ent", "<e2>", "and", "thrombotic", "thrombocytopenic", "purpura"], "h": {"id": "C0265374", "name": "C0265374#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0272375", "name": "C0272375#ent", "pos": [31, 32]}}
{"token": ["The", "three-dimensional", "structure", "not", "known", "for", "any", "intracellular", "phospholipase", "A2", "but", "these", "C3540772#ent", "<e1>", "share", "significant", "sequence", "homology", "with", "secreted", "C0031672#ent", "<e2>", ",", "for", "which", "some", "of", "the", "structures", "have", "been", "determined", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031672", "name": "C0031672#ent", "pos": [20, 21]}}
{"token": ["They", "might", "be", "lipids", "(", "e.g.", "slow", "irreversible", "inhibition", "by", "fatty", "acids", "relieved", "by", "serum", "albumin", "or", "inhibitory", "proteins", "RF", "and", "C3540772#ent", "<e1>", "(", "proteinases", "and", "C0031672#ent", "<e2>", ")", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0031672", "name": "C0031672#ent", "pos": [26, 27]}}
{"token": ["Selective", "inhibition", "of", "C0016384#ent", "<e1>", "will", "prevent", "C0242853#ent", "<e2>", "association", "with", "the", "plasma", "membrane", "leading", "to", "a", "disruption", "of", "oncogenic", "Ras", "function"], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [7, 8]}}
{"token": ["Common", "substrates", "of", "C0016384#ent", "<e1>", "include", "oncogenic", "C0242853#ent", "<e2>", "and", "therefore", "inhibitors", "are", "under", "development", "for", "the", "treatment", "of", "various", "cancers", "."], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [7, 8]}}
{"token": ["Paraoxon", ",", "an", "inhibitor", "of", "all", "C1258847#ent", "<e1>", "cholinesterase", "and", "C0054741#ent", "<e2>", ",", "decreased", "the", "hydrolysis", "of", "tazarotene", "to", "tazarotenic", "acid", "95", "%", "in", "both", "blood", "and", "liver", "microsomes", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "IL-2", "induced", "increased", "C1705050#ent", "<e1>", "phosphorylation", "and", "C1332712#ent", "<e2>", "expression", "in", "SOCS-1-deficient", "T", "cells", "compared", "with", "controls", "."], "h": {"id": "C1705050", "name": "C1705050#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332712", "name": "C1332712#ent", "pos": [9, 10]}}
{"token": ["Sensory", "ataxia", "distinguishable", "from", "cerebellar", "ataxia", "because", "the", "C0240991#ent", "<e1>", "symptoms", "to", "worsen", "when", "movements", "are", "made", "with", "the", "C0235267#ent", "<e2>", "closed", "."], "h": {"id": "C0240991", "name": "C0240991#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [19, 20]}}
{"token": ["In", "vitro", "in", "vivo", "studies", "have", "shown", "that", "C0031716#ent", "<e1>", "polymers", "have", "high", "biocompatibility", "due", "to", "low", "adsorption", "of", "C0086376#ent", "<e2>", "and", "reduced", "thrombus", "formation", "."], "h": {"id": "C0031716", "name": "C0031716#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["Phencyclidine", "(", "C1418873#ent", "<e1>", ")", "binds", "to", "many", "sites", "in", "brain", ",", "including", "C0031381#ent", "<e2>", "within", "the", "N-methyl-D-aspartate", "(", "NMDA", ")", "receptor-operated", "cation", "channel", "and", "sigma", "(", "sigma", ")", "receptors", "."], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [13, 14]}}
{"token": ["Paroxysmal", "exercise-induced", "dystonia", "C1417925#ent", "<e1>", ")", "is", "a", "rare", "disorder", "manifesting", "as", "episodes", "of", "C0013421#ent", "<e2>", "mostly", "affecting", "the", "feet", "induced", "by", "continuous", "exercise", "walking", "or", "running", "."], "h": {"id": "C1417925", "name": "C1417925#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013421", "name": "C0013421#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "the", "cytosolic", "domain", "C1423496#ent", "<e1>", "can", "be", "phosphorylated", "by", "the", "insulin", "receptor", "in", "vitro", "tyrosine", "phosphorylated", "C1423496#ent", "<e1>", "can", "specifically", "bind", "to", "the", "SH2", "domains", "the", "C0134982#ent", "<e1>"], "h": {"id": "C1423496", "name": "C1423496#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0134982", "name": "C0134982#ent", "pos": [28, 29]}}
{"token": ["The", "Scandinavian", "Simvastatin", "Survival", "Study", "4S", ")", "was", "designed", "to", "evaluate", "the", "effects", "of", "cholesterol", "reduction", "C0074554#ent", "<e1>", "on", "mortality", "and", "morbidity", "in", "patients", "with", "C1956346#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [16, 17]}, "relation": "may_prevent", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [25, 26]}}
{"token": ["Synonyms", ":", "fyrol", "DMMP", ";", "C1366044#ent", "<e1>", "dimethyl", "ester", "DMMP", ";", "methanephosphonic", "acid", "dimethyl", "ester", ";", "C0058222#ent", "<e2>"], "h": {"id": "C1366044", "name": "C1366044#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0058222", "name": "C0058222#ent", "pos": [16, 17]}}
{"token": ["Other", "associated", "symptoms", "and", "signs", "included", "neck", "stiffness", "sore", "throat", "cough", ",", "C0234179#ent", "<e1>", "abdominal", "pain", "seizure", ",", "dizziness", ",", "rhinorrhea", ",", "diarrhea", ",", "C0234178#ent", "<e2>", "skin", "rash", "hyperemic", "conjunctiva", "apnea", ",", "and", "oral", "ulcers"], "h": {"id": "C0234179", "name": "C0234179#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0234178", "name": "C0234178#ent", "pos": [24, 25]}}
{"token": ["Significant", "clinical", "improvement", "headache", ",", "C0037580#ent", "<e1>", "facial", "features", "hyperhidrosis", "and", "C0030554#ent", "<e2>", "occurred", "in", "all", "patients", "."], "h": {"id": "C0037580", "name": "C0037580#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030554", "name": "C0030554#ent", "pos": [11, 12]}}
{"token": ["From", "a", "classification", "point", "of", "view", ",", "some", "of", "these", "C0878544#ent", "<e1>", "are", "secondary", "to", "muscular", "dystrophies", "or", "to", "metabolic", "disorders", "or", "to", "other", "C0026848#ent", "<e2>", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [24, 25]}}
{"token": ["One", "hundred", "and", "four", "patients", "receiving", "hemodialysis", "and", "undergoing", "C0002871#ent", "<e1>", "treatment", "with", "C0937950#ent", "<e2>", "intravenously", "once", "weekly", "were", "switched", "to", "a", "biweekly", "dosing", "schedule", "and", "followed", "for", "24", "weeks", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0937950", "name": "C0937950#ent", "pos": [13, 14]}}
{"token": ["So", "far", ",", "three", "drugs", "have", "been", "approved", "for", "the", "treatment", "of", "C0002871#ent", "<e1>", "in", "patients", "with", "malignancies", "(", "epoetin", "alfa", "epoetin", "beta", "C0937950#ent", "<e2>", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0937950", "name": "C0937950#ent", "pos": [23, 24]}}
{"token": ["The", "majority", "of", "the", "C0456065#ent", "<e1>", "infants", "died", "from", "respiratory", "insufficiency", "sepsis", ",", "and", "C0520459#ent", "<e2>"], "h": {"id": "C0456065", "name": "C0456065#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0520459", "name": "C0520459#ent", "pos": [14, 15]}}
{"token": ["Only", "a", "handful", "of", "clinical", "parameters", "other", "than", "body", "weight", "used", "in", "managing", "C0456065#ent", "<e1>", "newborns", "with", "C0520459#ent", "<e2>", "NEC", ")", "."], "h": {"id": "C0456065", "name": "C0456065#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0520459", "name": "C0520459#ent", "pos": [17, 18]}}
{"token": ["For", "the", "clinician", ",", "the", "expanding", "number", "of", "genes", "and", "C0678933#ent", "<e1>", "these", "diseases", "and", "the", "enormous", "clinical", "heterogeneity", "of", "specific", "C0007758#ent", "<e2>", "subtypes", "complicate", "management", "of", "C0007758#ent", "<e2>", "patients", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [21, 22]}}
{"token": ["In", "noncancerous", "regions", "characterized", "by", "C1623038#ent", "<e1>", "in", "28", "cases", "and", "chronic", "hepatitis", "12", "cases", ",", "C1706544#ent", "<e2>", "was", "rarely", "expressed", "on", "hepatocytes", "but", "was", "expressed", "mainly", "on", "the", "endothelium", "of", "portal", "vessels", "sinusoidal", "lining", "cells"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [16, 17]}}
{"token": ["In", "this", "open", "prospective", "study", "the", "efficacy", "of", "C0081876#ent", "<e1>", "in", "reducing", "gastric", "acid", "secretion", "in", "C0043515#ent", "<e2>", "patients", "was", "compared", "to", "that", "obtained", "previously", "with", "other", "proton", "pump", "inhibitors"], "h": {"id": "C0081876", "name": "C0081876#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [16, 17]}}
{"token": ["In", "many", "type", "I", "endometrial", "cancers", "the", "PTEN", "gene", "inactivated", ",", "which", "ultimately", "leads", "to", "constitutively", "active", "Akt", "and", "the", "inhibition", "of", "Forkhead", "box", "O1", "C1333572#ent", "<e1>", ")", ",", "a", "member", "of", "the", "FOXO", "subfamily", "C1422249#ent", "<e2>", "transcription", "factors"], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1422249", "name": "C1422249#ent", "pos": [35, 36]}}
{"token": ["In", "many", "type", "I", "endometrial", "cancers", "the", "PTEN", "gene", "inactivated", ",", "which", "ultimately", "leads", "to", "constitutively", "active", "Akt", "and", "the", "inhibition", "of", "C1333572#ent", "<e1>", "FOXO1", ")", ",", "a", "member", "of", "the", "FOXO", "subfamily", "C1422249#ent", "<e2>", "transcription", "factors"], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1422249", "name": "C1422249#ent", "pos": [33, 34]}}
{"token": ["C1333572#ent", "<e1>", ",", "a", "member", "of", "the", "Fox0", "subfamily", "C1422249#ent", "<e2>", "is", "a", "target", "of", "insulin", "and", "insulin-like", "growth", "factor-1", "IGF-1", ")", "signal", "transduction", "pathways", "activate", "protein", "kinase", "B", "PKB", ")", "in", "pancreatic", "beta", "cells"], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422249", "name": "C1422249#ent", "pos": [9, 10]}}
{"token": ["We", "now", "report", "on", "the", "role", "of", "forkhead", "homologue", "in", "rhabdomyosarcoma", "(", "C1333572#ent", "<e1>", ")", ",", "a", "recently", "described", "member", "of", "the", "C1422249#ent", "<e2>", "as", "a", "mediator", "of", "endometrial", "differentiation"], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1422249", "name": "C1422249#ent", "pos": [22, 23]}}
{"token": ["CD28-", "and", "CTLA4", "homologs", "were", "found", "in", "all", "vertebrate", "classes", "C1415846#ent", "<e1>", "ICOS", ")", "was", "restricted", "to", "tetrapods", ",", "and", "C1418401#ent", "<e2>", "PD1", ")", "was", "limited", "to", "mammals", "and", "chicken", "."], "h": {"id": "C1415846", "name": "C1415846#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [20, 21]}}
{"token": ["Enzyme", "K", "activity", "inhibited", "by", "HgCl2", ",", "FeSO4", ",", "CuSO4", ",", "EDTA", ",", "C0037556#ent", "<e1>", "p-chloromercurobenzoate", "and", "iodoacetamide", "and", "was", "stimulated", "by", "2-mercaptoethanol", ",", "C0012789#ent", "<e2>", "and", "glutathione", "."], "h": {"id": "C0037556", "name": "C0037556#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [24, 25]}}
{"token": ["One", "of", "the", "objectives", "of", "the", "present", "work", "was", "to", "establish", "a", "comparison", "among", "denaturation", "by", "heat", ",", "C0037556#ent", "<e1>", "SDS", ")", "and", "C0012789#ent", "<e2>", "(", "DTT", ")", "."], "h": {"id": "C0037556", "name": "C0037556#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "there", "are", "clinical", ",", "microbiological", "and", "prognostic", "characteristics", "that", "distinguish", "C0275524#ent", "<e1>", "from", "monomicrobial", "C0004610#ent", "<e2>", "UTIs", "."], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [16, 17]}}
{"token": ["Deaths", "directly", "related", "to", "sepsis", "were", "twofold", "higher", "in", "C0275524#ent", "<e1>", "versus", "unimicrobial", "C0004610#ent", "<e2>", "."], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [13, 14]}}
{"token": ["This", "bacteriuria", "is", "C0275524#ent", "<e1>", "and", "dynamic", "and", "accompanied", "by", "fevers", ",", "catheter", "obstructions", "C0004610#ent", "<e2>", ",", "and", "deaths", "."], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [14, 15]}}
{"token": ["C1449006#ent", "<e1>", "KLK5", ")", "is", "a", "member", "of", "the", "human", "C0022478#ent", "<e2>", "serine", "proteases"], "h": {"id": "C1449006", "name": "C1449006#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022478", "name": "C0022478#ent", "pos": [10, 11]}}
{"token": ["Cultures", "of", "C2987364#ent", "<e1>", "(", "SulsMet+", ")", "gonococci", "on", "a", "conventional", "medium", "C0037134#ent", "<e2>", "(", "2", "-", "10", "micrograms", "ml-1", ")", "yielded", "numerous", ",", "nonidentical", "mutations", "of", "two", "met", "genes", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037134", "name": "C0037134#ent", "pos": [12, 13]}}
{"token": ["The", "relative", "binding", "affinity", "(", "RBA", ")", "of", "C0072063#ent", "<e1>", "was", "of", "the", "same", "order", "as", "that", "of", "C0016384#ent", "<e2>", ",", "a", "synthetic", "non-steroidal", "antiandrogen", "structurally", "similar", "to", "C0072063#ent", "<e1>", "."], "h": {"id": "C0072063", "name": "C0072063#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016384", "name": "C0016384#ent", "pos": [18, 19]}}
{"token": ["On", "the", "basis", "of", "these", "findings", ",", "we", "recommend", "screening", ",", "follow-up", ",", "and", "regular", "gastrointestinal", "care", "C0085077#ent", "<e1>", "patients", "to", "identify", "C1705969#ent", "<e2>", "cases", "and", "help", "them", "to", "avoid", "severe", "malnutrition", "and", "intestinal", "malignancies"], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [22, 23]}}
{"token": ["The", "C0085077#ent", "<e1>", "treatment", "was", "more", "effective", "in", "reducing", "labile", "pools", "of", "C1705969#ent", "<e2>", "and", "Ni", "and", "led", "to", "a", "greater", "recovery", "of", "soil", "enzyme", "activities", "than", "the", "B", "treatment"], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [12, 13]}}
{"token": ["Pituitary", "function", "studies", "performed", "in", "a", "patient", "with", "C0265257#ent", "<e1>", "mucopolysaccharidosis", "type", "IIB", "MPS", "IIB", "in", "order", "to", "exclude", "C3714796#ent", "<e2>", "a", "possible", "contributing", "cause", "of", "his", "short", "stature"], "h": {"id": "C0265257", "name": "C0265257#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714796", "name": "C3714796#ent", "pos": [19, 20]}}
{"token": ["Specific", "trypsin", "inhibitory", "activity", "and", "composition", "of", "C3539947#ent", "<e1>", "carbohydrates", "were", "similar", "to", "those", "of", "normal", "C0812214#ent", "<e2>", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812214", "name": "C0812214#ent", "pos": [16, 17]}}
{"token": ["Combination", "of", "C0751039#ent", "<e1>", "with", "either", "an", "ACE-Inhibitor", "or", "an", "C1516869#ent", "<e2>", "the", "endothelial", "dysfunction", "the", "rat", "arta", "observed", "after", "C0751039#ent", "<e1>", "alone.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "whether", "fibrin", "itself", "could", "initiate", "fibrinolysis", "without", "activating", "coagulation", "C3541394#ent", "<e1>", ",", "fibrin", "monomers", "prepared", "and", "added", "to", "C1418648#ent", "<e2>", "deficient", "plasma", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418648", "name": "C1418648#ent", "pos": [20, 21]}}
{"token": ["Significant", "relationships", "between", "C3887685#ent", "<e1>", "genotype", "and", "steady-state", "concentrations", "have", "been", "reported", "for", "C0031184#ent", "<e2>", ",", "zuclopenthixol", ",", "risperidone", "and", "haloperidol", "when", "used", "in", "monotherapy", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [3, 4]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0031184", "name": "C0031184#ent", "pos": [13, 14]}}
{"token": ["This", "study", "evaluates", "the", "importance", "of", "the", "C3887685#ent", "<e1>", "genotype", "for", "the", "disposition", "of", "the", "neuroleptic", "agents", "C0031184#ent", "<e2>", "and", "zuclopenthixol", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0031184", "name": "C0031184#ent", "pos": [17, 18]}}
{"token": ["Local", "application", "capsaicin", "depletes", "the", "C0031117#ent", "<e1>", "substance", "P", "may", "block", "the", "conduction", "of", "or", "C0033775#ent", "<e2>", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033775", "name": "C0033775#ent", "pos": [15, 16]}}
{"token": ["The", "apparent", "affinity", "of", "C1537503#ent", "<e1>", "for", "GS17C", ",", "a", "CaM-binding", "peptide", "of", "C0010068#ent", "<e2>", ",", "is", "weakened", "by", "CaT", ",", "suggesting", "CaT", "competes", "with", "C1537503#ent", "<e1>", "for", "the", "peptide", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "are", "consistent", "with", "model", "in", "which", "C1537503#ent", "<e1>", "binds", "to", "C0010068#ent", "<e2>", "in", "an", "antiparallel", "manner", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [12, 13]}}
{"token": ["Thus", "in", "the", "1:1", "complex", "of", "C0010068#ent", "<e1>", "and", "C1537503#ent", "<e2>", ",", "the", "CaM", "molecule", "almost", "always", "associated", "with", "C-terminus", "of", "C0010068#ent", "<e1>", ",", "indicating", "preferential", "CaM-binding", "to", "the", "C-terminal", "region"], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [6, 7]}}
{"token": ["CFDN", "was", "administered", "to", "11", "children", "with", "various", "C0004623#ent", "<e1>", "1", "patient", "with", "C0036285#ent", "<e2>", "1", "with", "pharyngotonsillitis", ",", "3", "with", "acute", "bronchitis", "3", "with", "pneumonia", "and", "3", "with", "urinary", "tract", "infections"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0036285", "name": "C0036285#ent", "pos": [13, 14]}}
{"token": ["Intensive", "care", "the", "pregnant", "mother", "C0011849#ent", "<e1>", "has", "dramatically", "decreased", "the", "incidence", "of", "C1167662#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1167662", "name": "C1167662#ent", "pos": [13, 14]}}
{"token": ["Oxidative", "stress", "recently", "been", "implicated", "in", "the", "pathogenesis", "of", "C0011849#ent", "<e1>", "complications", ",", "but", "its", "role", "in", "C1167662#ent", "<e2>", "not", "been", "studied", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1167662", "name": "C1167662#ent", "pos": [17, 18]}}
{"token": ["This", "latter", "component", "is", "blocked", "by", "Quin", "2", "C0280858#ent", "<e1>", "and", "also", "inhibited", "by", "yohimbine", ",", "an", "C0304513#ent", "<e2>"], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0304513", "name": "C0304513#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "present", "several", "lines", "of", "evidence", "indicating", "that", "C1832660#ent", "<e1>", "is", "a", "physiologically", "relevant", "C0287531#ent", "<e2>"], "h": {"id": "C1832660", "name": "C1832660#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0287531", "name": "C0287531#ent", "pos": [15, 16]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "both", "C1333664#ent", "<e2>", "and", "preproGHRF", "have", "been", "isolated", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333664", "name": "C1333664#ent", "pos": [5, 6]}}
{"token": ["The", "first", "patient", "presented", "with", "a", "12-year", "history", "of", "C0410198#ent", "<e1>", "arthropathy", "and", "skin", "abnormalities", "and", "florid", "C0027145#ent", "<e2>", "diagnosed", "."], "h": {"id": "C0410198", "name": "C0410198#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027145", "name": "C0027145#ent", "pos": [17, 18]}}
{"token": ["Physicians", "should", "be", "aware", "that", "treatment", "with", "C0025153#ent", "<e1>", "with", "concomitant", "C0025289#ent", "<e2>", "could", "have", "a", "risk", "of", "development", "of", "grand", "mal", "seizure"], "h": {"id": "C0025153", "name": "C0025153#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [11, 12]}}
{"token": ["An", "outstanding", "feature", "of", "bovine", "spleen", "C1332804#ent", "<e1>", "observed", "with", "the", "other", "C0699919#ent", "<e2>", "the", "presence", "of", "two", "additional", "half-cystine", "residues"], "h": {"id": "C1332804", "name": "C1332804#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [12, 13]}}
{"token": ["Topoisomerase", "I", "the", "target", "of", "anticancer", "drugs", "as", "C0006812#ent", "<e1>", "as", "well", "as", "a", "candidate", "target", "for", "new", "C0003308#ent", "<e2>"], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [18, 19]}}
{"token": ["Finally", ",", "some", "C0006812#ent", "<e1>", "analogs", "exhibit", "synergistic", "C0003308#ent", "<e2>", "yeast", "cells", "combination", "with", "amphotericin", "B", "in", "vitro"], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [8, 9]}}
{"token": ["The", "latter", "is", "impaired", "in", "DD", "because", "of", "mutations", "of", "C1567357#ent", "<e1>", "encodes", "the", "type", "2", "isoforms", "the", "C1412638#ent", "<e2>", "ER", ")", "Ca++", "ATPase", "2", "SERCA2", ")", "pump", "."], "h": {"id": "C1567357", "name": "C1567357#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412638", "name": "C1412638#ent", "pos": [18, 19]}}
{"token": ["To", "screen", "the", "C0678941#ent", "<e1>", "beta", "and", "C1415155#ent", "<e2>", "the", "epithelial", "sodium", "channel", "ENaC", ")", "of", "a", "Chinese", "family", "some", "of", "whose", "members", "are", "clinically", "diagnosed", "suffering", "from", "Liddle", "syndrome"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415155", "name": "C1415155#ent", "pos": [7, 8]}}
{"token": ["Among", "the", "C0017337#ent", "<e1>", "regulated", "by", "regular", "exercise", "the", "betaine-homocysteine", "methyltransferase", "2", "C1530588#ent", "<e2>", ")", "seems", "to", "be", "of", "particular", "interest", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1530588", "name": "C1530588#ent", "pos": [12, 13]}}
{"token": ["Collectively", ",", "these", "results", "suggest", "that", "C1420002#ent", "<e1>", "acts", "as", "a", "dual", "modulator", "of", "HIV", "infection", "protecting", "CD4+", "T", "cells", "C1708498#ent", "<e2>", "enhancing", "the", "transfer", "of", "infection", "to", "CD4+", "T", "cells", "by", "DCs", "."], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1708498", "name": "C1708498#ent", "pos": [20, 21]}}
{"token": ["Infection", "with", "HHV-6", "induces", "marked", "C1334159#ent", "<e1>", ",", "and", "an", "association", "both", "with", "cytomegalovirus", "disease", "with", "C0026946#ent", "<e2>", "transplant", "recipients", "has", "been", "reported", "."], "h": {"id": "C1334159", "name": "C1334159#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "the", "different", "C0001473#ent", "<e1>", "activities", "of", "four", "molluscan", "muscle", "myosins", "are", "likely", "due", "to", "C3815884#ent", "<e2>", "variations", "within", "the", "flexible", "surface", "loop", "forms", "part", "of", "the", "ATP", "binding", "pocket", "of", "the", "motor", "domain"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3815884", "name": "C3815884#ent", "pos": [16, 17]}}
{"token": ["We", "found", "that", "independently", "of", "C0009079#ent", "<e1>", "increased", "the", "plasma", "levels", "of", "tumor-necrosis-factor", "a", "(", "C0812246#ent", "<e2>", ")", "and", "soluble", "interleukin-2-receptor", "(", "sIL-2r", ")", "which", "were", "further", "increased", "by", "fever", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "the", "potential", "role", "of", "protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "in", "regulating", "the", "trafficking", "of", "surface", "C0694872#ent", "<e2>", "in", "Madin-Darby", "canine", "kidney", "cells"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "alpha", "2-adrenergic-receptor", "blocker", "mianserin", "on", "the", "responses", "of", "blood", "glucose", "C1335239#ent", "<e1>", "beta-TG", ")", ",", "and", "various", "counterregulatory", "hormones", "to", "insulin-induced", "C0020616#ent", "<e2>", "were", "studied", "in", "nine", "healthy", "male", "subjects", "."], "h": {"id": "C1335239", "name": "C1335239#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [24, 25]}}
{"token": ["In", "rat", "fibroblasts", "that", "overexpress", "C1709439#ent", "<e1>", ",", "the", "activation", "of", "C1979930#ent", "<e2>", "MAP", ")", "kinase", "by", "growth", "factors", "not", "affected", ",", "but", "activation", "by", "cell", "adhesion", "markedly", "impaired", "."], "h": {"id": "C1709439", "name": "C1709439#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1979930", "name": "C1979930#ent", "pos": [11, 12]}}
{"token": ["Genetic", "studies", "consistent", "with", "model", "in", "which", "C3538867#ent", "<e1>", "negatively", "regulates", "C1506818#ent", "<e2>", "."], "h": {"id": "C3538867", "name": "C3538867#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1506818", "name": "C1506818#ent", "pos": [11, 12]}}
{"token": ["The", "MDS", "arose", "from", "a", "pre-existing", "C0015625#ent", "<e1>", "progressed", "quickly", "to", "an", "acute", "myeloid", "leukemia", "C2828027#ent", "<e2>", "M2", ")", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [6, 7]}, "relation": "disease_has_associated_gene", "t": {"id": "C2828027", "name": "C2828027#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", ",", "via", "inhibition", "of", "protein", "geranylgeranylation", "C0246203#ent", "<e1>", "is", "a", "broadspectrum", "inhibitor", "of", "regulated", "C1336938#ent", "<e2>", "secretion", "."], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [17, 18]}}
{"token": ["Dysfunction", "of", "C1417055#ent", "<e1>", "has", "been", "implicated", "in", "the", "pathogenesis", "of", "expanded", "C1861303#ent", "<e2>", "repeats-associated", "myotonic", "dystrophy", "(", "DM", ")", "."], "h": {"id": "C1417055", "name": "C1417055#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1861303", "name": "C1861303#ent", "pos": [12, 13]}}
{"token": ["We", "demonstrate", "that", "C1417055#ent", "<e1>", "can", "bind", "short", "structured", "C1861303#ent", "<e2>", "and", "CCUG", "repeats", "high", "affinity", "and", "specificity", "."], "h": {"id": "C1417055", "name": "C1417055#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1861303", "name": "C1861303#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "the", "formation", "of", "multiple", ",", "lobulated", "C0033770#ent", "<e1>", "may", "suggest", "some", "particularity", "of", "C1333200#ent", "<e2>", "composition", "of", "the", "LC", "neurons", "."], "h": {"id": "C0033770", "name": "C0033770#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333200", "name": "C1333200#ent", "pos": [16, 17]}}
{"token": ["Microvilli", "isolated", "from", "MAT-C1", "13762", "ascites", "tumor", "cells", "extracted", "with", "Triton", "X-100", "phosphate-buffered", "saline", "C0033770#ent", "<e1>", ")", "to", "yield", "C1333200#ent", "<e2>"], "h": {"id": "C0033770", "name": "C0033770#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333200", "name": "C1333200#ent", "pos": [19, 20]}}
{"token": ["One", "consists", "of", "the", "detection", "of", "C1413864#ent", "<e1>", "carriers", "by", "subjecting", "them", "to", "oral", "C0008402#ent", "<e2>", "administration", "and", "monitoring", "the", "urinary", "excretion", "the", "bile", "alcohol", "5", "alpha,7", "alpha,12", "alpha,23,25-pentol", "before", "and", "after", "treatment", "."], "h": {"id": "C1413864", "name": "C1413864#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [14, 15]}}
{"token": ["C0037210#ent", "<e1>", "is", "a", "highly", "effective", "antibiotic", "for", "the", "treatment", "of", "C0077906#ent", "<e2>", "caused", "by", "gramnegative", "pathogens", "."], "h": {"id": "C0037210", "name": "C0037210#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0077906", "name": "C0077906#ent", "pos": [11, 12]}}
{"token": ["The", "C0016411#ent", "<e1>", "acetaminophen", ",", "7,8-benzoflavone", ",", "and", "C0025644#ent", "<e2>", "significantly", "reduced", "the", "mutagenicity", "of", "the", "promutagen", "N-nitrosodimethylamine", "the", "higher", "plant", "Arabidopsis", "thaliana"], "h": {"id": "C0016411", "name": "C0016411#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025644", "name": "C0025644#ent", "pos": [8, 9]}}
{"token": ["C3273436#ent", "<e1>", "also", "induces", "a", "threefold", "increase", "in", "mitogen-activated", "protein", "kinase", "C1370600#ent", "<e2>", ")", "activity", ",", "an", "effect", "that", "is", "not", "sensitive", "to", "pertussis", "toxin", "PTx", ")", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [11, 12]}}
{"token": ["After", "two", "weeks", ",", "the", "dosage", "was", "doubled", "(", "to", "40", "mg", "of", "C0014025#ent", "<e1>", "and", "100", "mg", "of", "C0004147#ent", "<e2>", ")", "in", "those", "patients", "with", "diastolic", "blood", "pressure", "than", "95", "mm", "Hg", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [19, 20]}}
{"token": ["The", "IL-10", "receptor", "IL-10R", ")", "consists", "of", "two", "subunits", ",", "IL-10R1", "and", "C1708417#ent", "<e1>", ",", "both", "belonging", "to", "the", "C1705305#ent", "<e2>"], "h": {"id": "C1708417", "name": "C1708417#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705305", "name": "C1705305#ent", "pos": [19, 20]}}
{"token": ["Treatment", "should", "be", "designed", "to", "decrease", "production", "of", "nephrotoxic", "light", "chains", "to", "prevent", "the", "binding", "interaction", "between", "these", "C0238239#ent", "<e1>", "the", "various", "structures", "of", "the", "C0722058#ent", "<e2>", "."], "h": {"id": "C0238239", "name": "C0238239#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0722058", "name": "C0722058#ent", "pos": [25, 26]}}
{"token": ["To", "define", "the", "utilization", "pattern", "of", "C0013231#ent", "<e1>", "patients", "with", "congestive", "heart", "failure", "C0019099#ent", "<e2>", ")", "and", "to", "compare", "this", "pattern", "with", "that", "of", "an", "age-", "and", "gender-matched", "control", "group", "without", "any", "self-reported", "heart", "conditions"], "h": {"id": "C0013231", "name": "C0013231#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [13, 14]}}
{"token": ["In", "Japan", ",", "about", "30", "cases", "of", "C0264444#ent", "<e1>", "accompanied", "with", "C0004364#ent", "<e2>", "been", "reported", "."], "h": {"id": "C0264444", "name": "C0264444#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [11, 12]}}
{"token": ["C1997142#ent", "<e1>", "was", "22", "%", "faster", "in", "C0030135#ent", "<e2>", "treated", "mice", "on", "day", "1", "but", "then", "reached", "the", "control", "levels", "day", "18", "."], "h": {"id": "C1997142", "name": "C1997142#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [7, 8]}}
{"token": ["Colonies", "of", "phoB+", "strains", "turn", "red", "on", "MacConkey", "indicator", "plates", "derepress", "the", "C0206522#ent", "<e1>", "the", "cells", "are", "able", "to", "ferment", "the", "C0524928#ent", "<e2>", "source", "."], "h": {"id": "C0206522", "name": "C0206522#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [21, 22]}}
{"token": ["Bacterial", "C0206522#ent", "<e1>", "involved", "in", "C0524928#ent", "<e2>", ",", "nitrogen", "and", "phosphorus", "metabolism", "interact", "for", "purposes", "of", "coordination", ",", "but", "the", "mechanisms", "involved", "are", "not", "understood", "."], "h": {"id": "C0206522", "name": "C0206522#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [5, 6]}}
{"token": ["The", "Western", "blotting", "that", "C1419818#ent", "<e1>", "patient", "convalescent", "serum", "could", "recognize", "the", "C0034857#ent", "<e2>"], "h": {"id": "C1419818", "name": "C1419818#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034857", "name": "C0034857#ent", "pos": [12, 13]}}
{"token": ["Hlp", "is", "most", "closely", "related", "to", "thymus", "LIM", "protein", ",", "and", "these", "two", "genes", "comprise", "a", "new", "C1517488#ent", "<e1>", "to", "the", "cysteine-rich", "protein", "C1826658#ent", "<e2>", ")", "C1517488#ent", "<e1>"], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1826658", "name": "C1826658#ent", "pos": [23, 24]}}
{"token": ["C0166059#ent", "<e1>", "activates", "the", "C1367721#ent", "<e2>", "EGF", ")", "receptor", "by", "releasing", "an", "EGF", "ligand", ",", "tumor", "growth", "factor", "(TGF)-alpha", "."], "h": {"id": "C0166059", "name": "C0166059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [4, 5]}}
{"token": ["The", "antimicrobial", "and", "C0003304#ent", "<e1>", "activities", "of", "essential", "oils", "orange", "oil", "eucalyptus", "oil", "fennel", "oil", "geranium", "oil", "C0304106#ent", "<e2>", "peppermint", "oil", "rosemary", "oil", "purified", "turpentine", "oil", "thyme", "oil", "Australian", "tea", "tree", "oil", "and", "of", "menthol", ",", "the", "main", "component", "of", "peppermint", "oil", "were", "investigated", "."], "h": {"id": "C0003304", "name": "C0003304#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0304106", "name": "C0304106#ent", "pos": [17, 18]}}
{"token": ["In", "vitro", "C0758527#ent", "<e1>", "behaved", "as", "a", "full", "C2987634#ent", "<e2>", "on", "adenylyl", "cyclase", "inhibition", "and", "as", "a", "partial", "C2987634#ent", "<e2>", "on", "[(35)S]GTPgammaS", "binding", "at", "the", "recombinant", "rat", "histamine", ")", "receptor", "."], "h": {"id": "C0758527", "name": "C0758527#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}}
{"token": ["When", "G", "alpha", "q/i5", "was", "used", ",", "the", "activity", "of", "both", "C0758527#ent", "<e1>", "and", "proxyfan", "increased", ",", "whereas", "imetit", "became", "a", "full", "C2987634#ent", "<e2>", "."], "h": {"id": "C0758527", "name": "C0758527#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [22, 23]}}
{"token": ["C0221023#ent", "<e1>", "a", "rare", "C0018939#ent", "<e2>", "characterized", "by", "repetitive", "episodes", "of", "fever", ",", "mouth", "ulcers", "and", "infections", "attributable", "to", "recurrent", "severe", "neutropenia", "."], "h": {"id": "C0221023", "name": "C0221023#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [4, 5]}}
{"token": ["C0669365#ent", "<e1>", "heterochromatin", "is", "marked", "by", "distinctive", "C3829685#ent", "<e2>", "methylation", "and", "the", "presence", "of", "HP1", "proteins", "but", "the", "chromatin", "modifications", "facultative", "heterochromatin", "less", "clear", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3829685", "name": "C3829685#ent", "pos": [7, 8]}}
{"token": ["This", "technique", "was", "applied", "to", "the", "identification", "of", "drugs", "such", "as", "salicylic", "acid", "phenol", ",", "acrinol", "and", "C0949738#ent", "<e1>", "and", "also", "C3714649#ent", "<e2>", "contained", "in", "the", "36", "kinds", "of", "preparation", "."], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [21, 22]}}
{"token": ["In", "combination", "therapy", "aliskiren", "further", "decreases", "blood", "pressure", "combined", "with", "either", "hydrochlorothiazide", ",", "amlodipine", ",", "C0216784#ent", "<e1>", ",", "irbesartan", ",", "or", "C0072973#ent", "<e2>", "."], "h": {"id": "C0216784", "name": "C0216784#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0072973", "name": "C0072973#ent", "pos": [21, 22]}}
{"token": ["Multiple", "sclerosis", "C0026269#ent", "<e1>", ")", "is", "the", "most", "common", "C1290884#ent", "<e2>", "the", "central", "nervous", "system"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [9, 10]}}
{"token": ["We", "measured", "the", "sera", "concentrations", "of", "IL-12", ",", "tumor", "necrosis", "factor", "and", "transforming", "growth", "factor-beta1", "in", "21", "C0026269#ent", "<e1>", "patients", "and", "13", "patients", "with", "C1290884#ent", "<e2>"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [24, 25]}}
{"token": ["Multiple", "sclerosis", "C0026269#ent", "<e1>", ")", "and", "its", "animal", "model", "experimental", "autoimmune", "encephalomyelitis", "EAE", ")", ",", "are", "C1290884#ent", "<e2>", "the", "central", "nervous", "system", "CNS", ")", "characterized", "by", "localized", "areas", "demyelination", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [16, 17]}}
{"token": ["The", "high", "substrate", "specificity", "of", "human", "C4085186#ent", "<e1>", "Ang", "I", "it", "from", "other", "Ang", "II-forming", "enzymes", "including", "Ang", "I", "C0027203#ent", "<e2>", ",", "tonin", ",", "kallikrein", ",", "cathepsin", "G", "and", "other", "known", "chymases", "."], "h": {"id": "C4085186", "name": "C4085186#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "the", "association", "of", "C4085186#ent", "<e1>", "heparin", "proteoglycan", "serve", "both", "to", "potentiate", "the", "catalytic", "activity", "the", "C0027203#ent", "<e2>", "and", "to", "increase", "the", "life-span", "of", "the", "chymases", "by", "preventing", "their", "inhibition", "after", "exocytosis", "."], "h": {"id": "C4085186", "name": "C4085186#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "C4085186#ent", "<e1>", "cleaved", "TFPI", "even", "at", "an", "C0027203#ent", "<e2>", "to", "substrate", "molar", "of", "1:500", ",", "resulting", "in", "markedly", "decreased", "TFPI", "anticoagulant", "and", "anti-(factor", "Xa", ")", "activities", "."], "h": {"id": "C4085186", "name": "C4085186#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["During", "the", "last", "six", "years", "400", "children", "with", "C0451641#ent", "<e1>", "underwent", "a", "six", "weeks", "rehabilitation", "treatment", "a", "specialized", "children's", "for", "C0022658#ent", "<e2>"], "h": {"id": "C0451641", "name": "C0451641#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [20, 21]}}
{"token": ["The", "enzyme", "behaves", "as", "a", "C0002570#ent", "<e1>", "and", "represents", "the", "prototype", "of", "a", "new", "C0010656#ent", "<e2>"], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [14, 15]}}
{"token": ["The", "L.", "monocytogenes", "aminopeptidase", "shares", "strong", "sequence", "similarity", "C0002570#ent", "<e1>", "Streptococcus", "thermophilous", "Lactobacillus", "lactis", "Lactobacillus", "helveticus", "and", "with", "a", "C0010656#ent", "<e2>", "Saccharomyces", "cerevisiae"], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [19, 20]}}
{"token": ["C0074250#ent", "<e1>", "produced", "similar", "C1705328#ent", "<e2>", "values", "with", "either", "CCh", "(", "8.19", ")", "or", "McN-A-343", "(", "8.13", ")", "as", "the", "agonist", "."], "h": {"id": "C0074250", "name": "C0074250#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [4, 5]}}
{"token": ["Cardiomyopathy", "is", "a", "major", "dose-limiting", "factor", "applications", "of", "C0085752#ent", "<e1>", ",", "a", "potent", "C0729502#ent", "<e2>"], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [13, 14]}}
{"token": ["C0085752#ent", "<e1>", ",", "a", "widely", "employed", "C0729502#ent", "<e2>", "is", "known", "to", "induce", "a", "nephrotic", "syndrome", "rats", "characterized", "by", "severe", "ultrastructural", "changes", "of", "glomerular", "epithelial", "cells", "by", "loss", "of", "glomerular", "polyanionic", "charges", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [6, 7]}}
{"token": ["C0019247#ent", "<e1>", "such", "as", "C0043459#ent", "<e2>", "are", "characterized", "by", "defects", "in", "one", "or", "more", "enzymes", "involved", "in", "the", "peroxisomal", "beta-oxidation", "very", "long", "chain", "fatty", "acids", "and", "are", "associated", "with", "defective", "peroxisomal", "biogenesis", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [4, 5]}}
{"token": ["C0085417#ent", "<e1>", "auditory", "features", "segregates", "in", "families", "as", "an", "C2936739#ent", "<e2>", "."], "h": {"id": "C0085417", "name": "C0085417#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [9, 10]}}
{"token": ["Human", "C1418965#ent", "<e1>", "2", "both", "converted", "C0054010#ent", "<e2>", "to", "bradykinin", "and", "released", "bradykinin", "from", "kininogen", "in", "human", "plasma", "as", "measured", "by", "bioassay", "with", "the", "isolated", "guinea", "pig", "ileum", "."], "h": {"id": "C1418965", "name": "C1418965#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054010", "name": "C0054010#ent", "pos": [6, 7]}}
{"token": ["Major", "known", "causes", "include", "cerebrovascular", "disease", "brain", "tumor", "C1285162#ent", "<e1>", "as", "Alzheimer", "disease", "cerebral", "amyloid", "angiopathy", "and", "toxic-metabolic", "syndromes", "as", "nonketotic", "hyperglycemia", "C0018790#ent", "<e2>", "and", "drug-induced", "seizures", "."], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018790", "name": "C0018790#ent", "pos": [22, 23]}}
{"token": ["Twenty-three", "patients", "with", "chronic", "myelogenous", "leukemia", "CML", ")", "in", "terminal", "transformation", "treated", "with", "regimen", "incorporating", "C0042682#ent", "<e1>", "(", "a", "new", "derivative", "of", "vinblastine", ")", ",", "C0032950#ent", "<e2>", ",", "and", "additional", "cytarabine", "."], "h": {"id": "C0042682", "name": "C0042682#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [25, 26]}}
{"token": ["The", "new", "regimen", "consisted", "of", "MCNU", "50", "-", "100", "mg", ",", "combined", "with", "C0042682#ent", "<e1>", "or", "6-MP", "plus", "allopurinol", "or", "C0032950#ent", "<e2>", "."], "h": {"id": "C0042682", "name": "C0042682#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [20, 21]}}
{"token": ["However", ",", "even", "live", "priming", "cats", "with", "feline", "herpesvirus", "FHV", ")", "vectors", "expressing", "the", "FIV", "gag", "C0017343#ent", "<e1>", "by", "inactivated", "booster", "vaccination", "fixed", "C1366464#ent", "<e2>", "infected", "cell", "vaccine", "non-protective", "against", "infection", "with", "a", "primary", "FIV", "isolate", "."], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1366464", "name": "C1366464#ent", "pos": [23, 24]}}
{"token": ["Although", "the", "TG", "sequence", "impedes", "C1333365#ent", "<e1>", "association", "with", "DNA", "ends", ",", "it", "allows", "C1417250#ent", "<e2>", "association", "."], "h": {"id": "C1333365", "name": "C1333365#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417250", "name": "C1417250#ent", "pos": [14, 15]}}
{"token": ["FSR", "C0035379#ent", "<e1>", "clones", "expressed", "high", "levels", "of", "lysyl", "oxidase", "C1705572#ent", "<e2>", "mRNA", "but", "grew", "only", "poorly", "in", "semisolid", "agar", "medium", "as", "opposed", "to", "anchorage-independent", "parental", "FE-8", "cells", "."], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [10, 11]}}
{"token": ["Recent", "victims", "appear", "to", "be", "published", "reports", "NANB", "being", "identified", "as", "a", "C0599685#ent", "<e1>", "NANB", "virus", "being", "propagated", "in", "primary", "cultures", "chimpanzee", "C0669372#ent", "<e2>", "."], "h": {"id": "C0599685", "name": "C0599685#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [22, 23]}}
{"token": ["In", "clinical", "aspects", "dengue", "infection", "be", "confused", "with", "C0025007#ent", "<e1>", ",", "rubella", ",", "influenza", ",", "acute", "mumps", "C0014378#ent", "<e2>", "food", "allergies"], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014378", "name": "C0014378#ent", "pos": [17, 18]}}
{"token": ["Telomere", "repeat", "sequences", "added", "to", "linear", "chromosome", "by", "telomerase", ",", "an", "enzyme", "comprising", "a", "C1955880#ent", "<e1>", "TERT", ")", "and", "an", "RNA", "template", "component", "(", "C1705312#ent", "<e2>", ")", "."], "h": {"id": "C1955880", "name": "C1955880#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705312", "name": "C1705312#ent", "pos": [24, 25]}}
{"token": ["A", "case", "of", "C2931375#ent", "<e1>", "to", "progressive", "C0016037#ent", "<e2>", "reported", "."], "h": {"id": "C2931375", "name": "C2931375#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016037", "name": "C0016037#ent", "pos": [7, 8]}}
{"token": ["Acid", "secretion", "estimated", "by", "[14C]aminopyrine", "uptake", "was", "well", "correlated", "with", "parallel", "enzymatic", "and", "immunoblot", "assays", "the", "redistribution", "of", "C0018437#ent", "<e1>", "from", "TV", "to", "C1825840#ent", "<e2>", "membranes", "."], "h": {"id": "C0018437", "name": "C0018437#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [23, 24]}}
{"token": ["C0018437#ent", "<e1>", "vesicles", "of", "C1825840#ent", "<e2>", "suggests", "that", "a", "specific", "configuration", "of", "ruffled", "borders", "in", "RA", "may", "be", "formed", "by", "the", "fusion", "of", "vesicle", "membranes", "the", "distal", "end", "of", "cytoplasm", "of", "C1825840#ent", "<e2>", "."], "h": {"id": "C0018437", "name": "C0018437#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [4, 5]}}
{"token": ["Forskolin-dependent", "adenylate", "cyclase", "activity", "in", "particulate", "turkey", "C1420193#ent", "<e1>", "enhanced", "following", "preincubation", "of", "membranes", "with", "C0282210#ent", "<e2>", "and", "GMP", "(", "cleared", "membranes", "."], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [15, 16]}}
{"token": ["Activity", "in", "turkey", "C1420193#ent", "<e1>", "stimulated", "by", "C0282210#ent", "<e2>", "."], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [7, 8]}}
{"token": ["Human", "T-cell", "leukemia/lymphotropic", "virus", "type", "I", "HTLV-I", ")", "infection", "causes", "a", "variety", "of", "C0012634#ent", "<e1>", "including", "adult", "C1420651#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420651", "name": "C1420651#ent", "pos": [17, 18]}}
{"token": ["HTLV-1", "is", "an", "important", "factor", "involved", "in", "various", "C0012634#ent", "<e1>", "including", "adult", "C1420651#ent", "<e2>", "HTLV-1", "associated", "myelopathy/tropical", "spastic", "paraparesis", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420651", "name": "C1420651#ent", "pos": [12, 13]}}
{"token": ["Lack", "of", "C1367307#ent", "<e1>", "in", "fully", "activated", "cells", "impaired", "the", "suppressive", "effects", "of", "C1426048#ent", "<e2>", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426048", "name": "C1426048#ent", "pos": [13, 14]}}
{"token": ["Similar", "levels", "of", "C1413132#ent", "<e1>", "activation", "and", "cleavage", "of", "C0534519#ent", "<e2>", "substrates", "occurred", ",", "showing", "that", "overall", ",", "CHRC5", "cells", "are", "not", "resistant", "to", "hyperthermia-induced", "apoptosis", "to", "AuxB1", "cells", "."], "h": {"id": "C1413132", "name": "C1413132#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [9, 10]}}
{"token": ["Several", "of", "these", "C0086376#ent", "<e1>", "were", "differentially", "expressed", "in", "two", "cell", "lines", "Raji", "and", "C1333212#ent", "<e2>", "(", "C-1-tetrahydrofolate", "synthase", "elongation", "factor", "2", "alpha-", "and", "beta-tubulin", ",", "transgelin-2", "and", "stathmin", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333212", "name": "C1333212#ent", "pos": [14, 15]}}
{"token": ["Recent", "work", "has", "identified", "DNA", "polymerase", "epsilon", "Ku", ",", "and", "C0086376#ent", "<e1>", "such", "as", "DNA-PKcs", ",", "C1333212#ent", "<e2>", "and", "Tel1", "as", "key", "players", "in", "DNA", "damage", "recognition", "pathways", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333212", "name": "C1333212#ent", "pos": [16, 17]}}
{"token": ["The", "3'-->5", "'", "exonuclease", "activity", "C0086376#ent", "<e1>", "derived", "from", "the", "C1333212#ent", "<e2>", "genomic", "open", "reading", "frame", "the", "intronless", "open", "reading", "frame", ",", "and", "several", "mutants", "was", "investigated", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333212", "name": "C1333212#ent", "pos": [10, 11]}}
{"token": ["C0917798#ent", "<e1>", "an", "important", "C0042373#ent", "<e2>", "and", "zinc", "is", "a", "necessary", "trace", "element", "humans", "."], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [4, 5]}}
{"token": ["In", "our", "experience", ",", "technical", "details", "monitoring", "and", "minimizing", "C0917798#ent", "<e1>", "possibly", "more", "crucial", "in", "these", "severe", "C0042373#ent", "<e2>", "patients", "."], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [17, 18]}}
{"token": ["Although", "it", "is", "well", "recognized", "that", "C3541395#ent", "<e1>", "enhance", "renal", "acid", "excretion", ",", "the", "effect", "of", "C3540778#ent", "<e2>", "on", "renal", "acidification", "unclear", "."], "h": {"id": "C3541395", "name": "C3541395#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [16, 17]}}
{"token": ["Type", "I", "corticosteroid", "receptors", "down", "regulated", "by", "excess", "of", "C3541395#ent", "<e1>", "(", "primary", "and", "secondary", "hyperaldosteronism", "pseudohyperaldosteronism", ")", "and", "of", "C3540778#ent", "<e2>", "(", "Cushing's", "syndrome", "."], "h": {"id": "C3541395", "name": "C3541395#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [20, 21]}}
{"token": ["Mammalian", "\"", "Type", "I", "C1706170#ent", "<e1>", ",", "synthesized", "primarily", "by", "the", "C0771711#ent", "<e2>", ",", "is", "also", "present", "in", "smaller", "amounts", "in", "other", "tissues", "including", "lung", ",", "spleen", ",", "and", "kidney", "."], "h": {"id": "C1706170", "name": "C1706170#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [11, 12]}}
{"token": ["Experimental", "studies", "ischemia-reperfusion", "and", "C0243026#ent", "<e1>", "indicate", "that", "C1170000#ent", "<e2>", "APC", ")", "has", "direct", "anti-inflammatory", "effects", "a", "cellular", "level"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C1170000", "name": "C1170000#ent", "pos": [8, 9]}}
{"token": ["We", "describe", "a", "patient", "with", "C0243026#ent", "<e1>", "and", "respiratory", "failure", "Ultra", "High", "Frequency", "Jet", "Ventilator", "who", "was", "started", "on", "C1170000#ent", "<e2>", "without", "the", "development", "of", "any", "significant", "bleeding", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C1170000", "name": "C1170000#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "we", "assessed", "the", "dynamic", "changes", "in", "biomarkers", "and", "coagulation", "parameters", "in", "surgical", "patients", "with", "severe", "C0243026#ent", "<e1>", "enrolled", "in", "PROWESS", "and", "treated", "with", "placebo", "or", "C1170000#ent", "<e2>", "activated", ")", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C1170000", "name": "C1170000#ent", "pos": [28, 29]}}
{"token": ["The", "results", "indicate", "that", "Smads", "are", "targets", "of", "C1515406#ent", "<e1>", "and", "that", "astrocytes", "are", "able", "to", "modulate", "Smads", "proteins", "C3537450#ent", "<e2>", "-", "1", "cells", "through", "the", "release", "of", "C1515406#ent", "<e1>", "."], "h": {"id": "C3537450", "name": "C3537450#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1515406", "name": "C1515406#ent", "pos": [8, 9]}}
{"token": ["Several", "heterozygous", "mutations", "within", "the", "gene", "encoding", "the", "alpha-subunit", "of", "Gs", "(", "GNAS1", ")", ",", "the", "G", "protein", "stimulates", "C1382029#ent", "<e1>", "have", "been", "previously", "identified", "in", "patients", "with", "C2931404#ent", "<e2>", "AHO", ")", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2931404", "name": "C2931404#ent", "pos": [28, 29]}}
{"token": ["C0812246#ent", "<e1>", "activity", "was", "assayed", "by", "measuring", "cytotoxicity", "against", "C3536807#ent", "<e2>", "D-treated", "L929", "cells", "and", "C0812246#ent", "<e1>", "was", "determined", "quantitatively", "by", "sandwich", "enzyme-linked", "immunosorbent", "assay", "ELISA", ")", "with", "polyclonal", "and", "monoclonal", "antibodies", "TNF-alpha", "."], "h": {"id": "C3536807", "name": "C3536807#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [0, 1]}}
{"token": ["C0025294#ent", "<e1>", "shocks", "may", "induce", "fatal", "C0034063#ent", "<e2>"], "h": {"id": "C0025294", "name": "C0025294#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [6, 7]}}
{"token": ["By", "these", "procedures", "valproate", "and", "the", "C0005064#ent", "<e1>", ",", "diazepam", "and", "C0009011#ent", "<e2>", ",", "exerted", "a", "potent", "antiproliferative", "action", "could", "not", "be", "attributed", "to", "increased", "cytotoxicity", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [6, 7]}, "relation": "chemical_structure_of", "t": {"id": "C0009011", "name": "C0009011#ent", "pos": [11, 12]}}
{"token": ["The", "final", "diagnosis", "of", "the", "first", "patient", "was", "C0002390#ent", "<e1>", "of", "the", "second", "one", "was", "C0008677#ent", "<e2>"], "h": {"id": "C0002390", "name": "C0002390#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [15, 16]}}
{"token": ["The", "results", "demonstrated", "that", "light", "meromyosin", "C0027117#ent", "<e1>", "the", "major", "domains", "of", "myosin", "interacting", "with", "C0056248#ent", "<e2>", "."], "h": {"id": "C0027117", "name": "C0027117#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0056248", "name": "C0056248#ent", "pos": [15, 16]}}
{"token": ["C2987364#ent", "<e1>", "torsinA", "expressed", "in", "CAD", "cells", "with", "endogenous", "C1416692#ent", "<e2>", "at", "the", "distal", "end", "of", "processes", ",", "whereas", "mutant", "torsinA", "remained", "confined", "to", "the", "cell", "body"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416692", "name": "C1416692#ent", "pos": [9, 10]}}
{"token": ["In", "keeping", "with", "these", "data", ",", "ASMC", "expressed", "C1705006#ent", "<e1>", "but", "not", "C1336639#ent", "<e2>", "or", "TLR8", "."], "h": {"id": "C1705006", "name": "C1705006#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1336639", "name": "C1336639#ent", "pos": [12, 13]}}
{"token": ["It", "would", "seem", "that", "venlafaxine", "is", "as", "effective", "as", "C0016365#ent", "<e1>", "when", "combined", "with", "C1412770#ent", "<e2>", "in", "the", "treatment", "of", "atypical", "AN", "."], "h": {"id": "C0016365", "name": "C0016365#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412770", "name": "C1412770#ent", "pos": [14, 15]}}
{"token": ["He", "developed", "C0302809#ent", "<e1>", "by", "marked", "elevation", "of", "C0012892#ent", "<e2>", "probably", "from", "the", "lymphocytopenic", "and", "immunosuppressive", "status", "induced", "by", "imatinib", "mesylate", "."], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [8, 9]}}
{"token": ["Correlation", "between", "sensibility", "of", "PGF2", "alpha", "dose-response", ")", "curve", "and", "parameters", "of", "inductibility", "-", "C0720099#ent", "<e1>", "of", "gestation", ",", "cervix", "score", "application", "of", "estrogens", "and", "C0700649#ent", "<e2>", "were", "investigated", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0700649", "name": "C0700649#ent", "pos": [25, 26]}}
{"token": ["We", "then", "applied", "this", "resource", "to", "the", "study", "of", "human", "ciliation", "disorders", "have", "identified", "C1412750#ent", "<e1>", ",", "a", "novel", "C0017337#ent", "<e2>", "for", "Bardet-Biedl", "syndrome"], "h": {"id": "C1412750", "name": "C1412750#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["Twenty-four", "hours", "after", "the", "final", "treatment", "both", "groups", "were", "tested", "for", "their", "responses", "to", "the", "C3536925#ent", "<e1>", "apomorphine", ",", "the", "5-hydroxytryptamine", "agonist", "quipazine", ",", "and", "the", "C0001640#ent", "<e2>", "clonidine", "."], "h": {"id": "C3536925", "name": "C3536925#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [26, 27]}}
{"token": ["Those", "with", "C1334889#ent", "<e1>", "had", "significantly", "higher", "rates", "of", "fetal", "growth", "retardation", "cesarean", "delivery", "of", "C0015930#ent", "<e2>"], "h": {"id": "C1334889", "name": "C1334889#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015930", "name": "C0015930#ent", "pos": [15, 16]}}
{"token": ["The", "higher", "ability", "of", "the", "pure", "C0752229#ent", "<e1>", "to", "down", "regulate", "C0376515#ent", "<e2>", "expression", "may", "explain", "the", "superiority", "of", "the", "pure", "C0752229#ent", "<e1>", "to", "induce", "apoptosis", "and", "to", "inhibit", "the", "growth", "of", "MCF-7", "cells"], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0752229", "name": "C0752229#ent", "pos": [6, 7]}}
{"token": ["Estrogen-induced", "increases", "in", "C0376515#ent", "<e1>", "are", "significantly", "inhibited", "by", "inclusion", "of", "the", "pure", "C0752229#ent", "<e2>", "ICI", "164,384", "in", "the", "medium", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752229", "name": "C0752229#ent", "pos": [13, 14]}}
{"token": ["Calcium", "oxalate", "risk", "index", "hypercalciuric", "and", "C0268167#ent", "<e1>", "patients", "was", "significantly", "reduced", "after", "the", "administration", "of", "C0280858#ent", "<e2>", "."], "h": {"id": "C0268167", "name": "C0268167#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [16, 17]}}
{"token": ["One", "of", "the", "C3540017#ent", "<e1>", "is", "presumably", "a", "type", "II", "topoisomerase", "i.e.", ",", "in", "C0101555#ent", "<e2>", "reactions", "it", "can", "catenate", "closed", "circular", "plasmid", "DNA", ",", "and", "decatenate", "closed", "circular", "kinetoplast", "DNA", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [14, 15]}}
{"token": ["The", "properties", "of", "the", "C3540017#ent", "<e1>", "are", "similar", "to", "those", "of", "C0101555#ent", "<e2>", "GSSG-transport", "systems", "in", "human", "erythrocytes", ",", "suggesting", "that", "these", "ATPases", "may", "function", "in", "the", "active", "transport", "GSSG", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [11, 12]}}
{"token": ["About", "20", "and", "30", "%", "of", "the", "AChE", "and", "BuChE", "activities", "were", "recovered", "in", "C1835435#ent", "<e1>", "and", "most", "of", "the", "remaining", "C3540790#ent", "<e2>", "in", "S2", "."], "h": {"id": "C1835435", "name": "C1835435#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [21, 22]}}
{"token": ["In", "GH3", "pituitary", "cell", "homogenates", ",", "acetylcholine", "(", "ACh", ")", "(", "IC50", "200", "nM", ")", "inhibits", "C1382029#ent", "<e1>", "ATP", "pyrophosphate-lyase", "(", "cyclizing", ")", ",", "C1137703#ent", "<e2>", "activity", "in", "a", "concentration-", "and", "GTP-dependent", "manner", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [16, 17]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1137703", "name": "C1137703#ent", "pos": [24, 25]}}
{"token": ["A", "maximally", "effective", "concentration", "of", "the", "beta-adrenoceptor", "partial", "agonist", "ephedrine", "displayed", "similar", "intrinsic", "activity", "potency", "to", "stimulate", "C1382029#ent", "<e1>", "membranes", "of", "clones", "both", "with", "and", "without", "C1137703#ent", "<e2>"], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [17, 18]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1137703", "name": "C1137703#ent", "pos": [26, 27]}}
{"token": ["When", "mucosally", "C0342895#ent", "<e1>", ",", "rice", "seeds", "expressing", "C1418397#ent", "<e2>", "were", "taken", "up", "by", "the", "M", "cells", "the", "Peyer's", "patches", "induced", "CTB-specific", "serum", "IgG", "mucosal", "IgA", "antibodies", "with", "neutralizing", "activity", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418397", "name": "C1418397#ent", "pos": [8, 9]}}
{"token": ["Clinical", "manifestations", "such", "phenomena", "may", "include", "an", "acute", "systemic", "vasculitic", "syndrome", "skin", "vasculitis", "fever", ",", "arthritis", ",", "pulmonary", "infiltrates", "peripheral", "polyneuropathy", "inflammatory", "bowel", "disease", "glomerulonephritis", ",", "and", "even", "classical", "C0009782#ent", "<e1>", "such", "as", "C0032453#ent", "<e2>"], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0032453", "name": "C0032453#ent", "pos": [33, 34]}}
{"token": ["This", "usage", "is", "indicative", "for", "the", "presumable", "presence", "of", "C0003308#ent", "<e1>", "inhibitors", "of", "xanthine", "and", "C0026454#ent", "<e2>"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [15, 16]}}
{"token": ["The", "vasodepressor", "response", "to", "5-CT", "was", "antagonized", "by", "C0025654#ent", "<e1>", "but", "not", "affected", "by", "mesulergine", ",", "ketanserin", ",", "C0033497#ent", "<e2>", ",", "or", "yohimbine", "."], "h": {"id": "C0025654", "name": "C0025654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [18, 19]}}
{"token": ["Antagonists", "at", "the", "5-HT1B", "site", "include", "the", "drugs", "C0025654#ent", "<e1>", ",", "metergoline", ",", "cyanopindolol", ",", "isamoltane", ",", "and", "C0033497#ent", "<e2>", "but", "none", "of", "these", "drugs", "are", "selective", "for", "this", "receptor", "."], "h": {"id": "C0025654", "name": "C0025654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [18, 19]}}
{"token": ["The", "inhibition", "was", "prevented", "by", "methysergide", "and", "C0025654#ent", "<e1>", "but", "not", "by", "ketanserin", ",", "C0033497#ent", "<e2>", ",", "3", "alpha-tropanyl-1H-indole-3-carboxylic", "acid", "ester", "hemoglobin", ",", "or", "nitro-L-arginine", "."], "h": {"id": "C0025654", "name": "C0025654#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [14, 15]}}
{"token": ["C0053471#ent", "<e1>", "inhibited", "PARP", ",", "apparently", "by", "direct", "interaction", "with", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C0053471", "name": "C0053471#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["C0537894#ent", "<e1>", "and", "anidulafungin", "are", "licensed", "for", "the", "treatment", "of", "C0877445#ent", "<e2>", ",", "and", "other", "select", "forms", "of", "invasive", "candidiasis"], "h": {"id": "C0537894", "name": "C0537894#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0877445", "name": "C0877445#ent", "pos": [10, 11]}}
{"token": ["We", "have", "previously", "isolated", "and", "characterized", "a", "mouse", "cDNA", "orthologous", "to", "the", "human", "synovial", "sarcoma", "C3273634#ent", "<e1>", "(", "formerly", "named", "SSXT", "and", "C1420439#ent", "<e2>", ")", "cDNA", "."], "h": {"id": "C3273634", "name": "C3273634#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420439", "name": "C1420439#ent", "pos": [22, 23]}}
{"token": ["The", "N-terminal", "interaction", "domain", "of", "the", "C3273634#ent", "<e1>", "also", "found", "to", "be", "present", "in", "several", "C1420439#ent", "<e2>", "orthologs", "and", "homologs", "."], "h": {"id": "C3273634", "name": "C3273634#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420439", "name": "C1420439#ent", "pos": [15, 16]}}
{"token": ["The", "increase", "in", "intracellular", "Ca++", "may", "activate", "several", "enzymatic", "pathways", "as", "phospholipase", "A2", "metabolism", "of", "arachidonic", "acid", "cyclooxygenase", "and", "lipoxygenase", ",", "conversion", "of", "xanthine", "dehydrogenase", "xanthine", "oxidase", "C0030940#ent", "<e1>", "and", "activation", "of", "C0907533#ent", "<e2>"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [32, 33]}}
{"token": ["Other", "C0030940#ent", "<e1>", "substrates", "with", "C0907533#ent", "<e2>", "active", "CaMKIV", "may", "function", "as", "endogenous", "mediators", "of", "activity-dependent", "changes", "in", "myofiber", "phenotype", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}}
{"token": ["These", "results", "clarify", "roles", "for", "different", "classes", "of", "C0030940#ent", "<e1>", "in", "a", "physiologically", "important", "form", "of", "C0907533#ent", "<e2>", "apoptosis", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [16, 17]}}
{"token": ["However", ",", "C1851585#ent", "<e1>", "treatments", "prevented", "the", "EV-induced", "elevation", "in", "C1384672#ent", "<e2>", "."], "h": {"id": "C1851585", "name": "C1851585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1384672", "name": "C1384672#ent", "pos": [10, 11]}}
{"token": ["Marked", "increases", "in", "serum", "immunoglobulin", "G", "IgG", ")", "autoantibodies", "to", "glial", "fibrillary", "acidic", "protein", "to", "C1826396#ent", "<e1>", "200", "were", "observed", "after", "the", "development", "of", "C2697821#ent", "<e2>", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2697821", "name": "C2697821#ent", "pos": [24, 25]}}
{"token": ["The", "two", "related", "C0812288#ent", "<e1>", "Syk", "and", "C1428222#ent", "<e2>", "are", "rapidly", "phosphorylated", "on", "tyrosine", "residues", "and", "enzymatically", "activated", "upon", "crosslinking", "of", "the", "T", "cell", "antigen", "receptor"], "h": {"id": "C0812288", "name": "C0812288#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428222", "name": "C1428222#ent", "pos": [7, 8]}}
{"token": ["C0010749#ent", "<e1>", "required", "reducing", "agents", ",", "of", "which", "C0012789#ent", "<e2>", "was", "the", "most", "effective", "."], "h": {"id": "C0010749", "name": "C0010749#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [8, 9]}}
{"token": ["A", "case", "of", "C0455988#ent", "<e1>", "associated", "with", "supraventricular", "tachycardia", "successfully", "treated", "with", "digoxin", "and", "C0042523#ent", "<e2>", "."], "h": {"id": "C0455988", "name": "C0455988#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [14, 15]}}
{"token": ["Patch", "tests", "first", "examined", "at", "30", "min", "for", "immediate", "patch", "test", "IPT", ")", "reactions", ",", "and", "again", "at", "C1414052#ent", "<e1>", "and", "D4", "for", "delayed", "patch", "test", "(", "C1414143#ent", "<e2>", ")", "reactions", "."], "h": {"id": "C1414052", "name": "C1414052#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414143", "name": "C1414143#ent", "pos": [27, 28]}}
{"token": ["C0426576#ent", "<e1>", "myotonic", "dystrophy", "increasingly", "observed", ",", "but", "major", "intestinal", "C0026650#ent", "<e2>", "as", "intestinal", "pseudo-obstruction", "appear", "to", "be", "an", "infrequent", "complication", "."], "h": {"id": "C0426576", "name": "C0426576#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [10, 11]}}
{"token": ["This", "enhancement", "is", "due", "to", "the", "physiological", "effect", "the", "C3541397#ent", "<e1>", "on", "the", "C0017168#ent", "<e2>", "and", "not", "due", "to", "its", "viscosity", "."], "h": {"id": "C3541397", "name": "C3541397#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [13, 14]}}
{"token": ["C0700478#ent", "<e1>", "and", "perphenazine", "had", "similar", "effects", "on", "C0520909#ent", "<e2>", "44", "%", "vs", "41", "%", ";", "ondansetron", "vs", "perphenazine", "P", "=", "0.77", ")", "."], "h": {"id": "C0700478", "name": "C0700478#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0520909", "name": "C0520909#ent", "pos": [8, 9]}}
{"token": ["In", "vivo", "was", "based", "on", "the", "C0030086#ent", "<e1>", "model", "of", "C0475718#ent", "<e2>", "."], "h": {"id": "C0030086", "name": "C0030086#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0475718", "name": "C0475718#ent", "pos": [10, 11]}}
{"token": ["Four", "weeks", "after", "the", "endothelial", "denudation", "of", "carotid", "artery", "had", "been", "performed", "12", "weeks", "after", "C0030086#ent", "<e1>", ",", "the", "intimal", "hyperplasia", "greatly", "augmented", "with", "C0475718#ent", "<e2>", "."], "h": {"id": "C0030086", "name": "C0030086#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0475718", "name": "C0475718#ent", "pos": [24, 25]}}
{"token": ["Prevalence", "of", "various", "C3714509#ent", "<e1>", "47.42", "%", ",", "anaemia", "and", "C1510471#ent", "<e2>", "the", "commonest", "among", "them", "."], "h": {"id": "C3714509", "name": "C3714509#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C1510471", "name": "C1510471#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "heparin-binding", "peptides", "from", "laminin", "isoforms", "von", "Willebrand", "factor", "vitronectin", ",", "C1418370#ent", "<e1>", "and", "fibronectin", ",", "exerted", "C1136254#ent", "<e2>", "Gram-positive", "and", "Gram-negative", "bacteria"], "h": {"id": "C1418370", "name": "C1418370#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [18, 19]}}
{"token": ["There", "are", "only", "two", "replacements", "between", "an", "18-residue", "portion", "of", "the", "C1305923#ent", "<e1>", "rabbit", "C0034348#ent", "<e2>", "a", "portion", "of", "the", "C1305923#ent", "<e1>", "enzyme", "isolated", "from", "sturgeon", "muscle", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [11, 12]}}
{"token": ["Enzyme", "II", "permeases", "of", "the", "C0034348#ent", "<e1>", ":", "glycose", "phosphotransferase", "system", "one", "to", "five", "separately", "encoded", "C1305923#ent", "<e2>", ",", "but", "most", "contain", "similar", "domains", "(", "IIA", ",", "IIB", ",", "and", "IIC", ")", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [16, 17]}}
{"token": ["X-linked", "agammaglobulinemia", "C2698304#ent", "<e1>", ")", "is", "one", "of", "the", "most", "frequent", "inherited", "C0019693#ent", "<e2>", "man", "and", "is", "characterized", "by", "an", "almost", "complete", "arrest", "of", "B", "cell", "differentiation", "at", "the", "pre-B", "cell", "stage"], "h": {"id": "C2698304", "name": "C2698304#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [12, 13]}}
{"token": ["X", "linked", "agammaglobulinemia", "C2698304#ent", "<e1>", ")", "is", "an", "C0019693#ent", "<e2>", "by", "mutations", "in", "the", "gene", "coding", "Bruton's", "agammaglobulinemia", "tyrosine", "kinase", "BTK", ")", ",", "that", "is", "involved", "in", "signal", "transduction", "pathways", "survival", ",", "activation", ",", "proliferation", ",", "and", "differentiation", "of", "B", "lineage", "lymphoid", "cells"], "h": {"id": "C2698304", "name": "C2698304#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [8, 9]}}
{"token": ["X-linked", "agammaglobulinemia", "C2698304#ent", "<e1>", ")", "is", "an", "inherited", "C0019693#ent", "<e2>", "characterized", "by", "an", "arrest", "in", "B-cell", "development", "which", "results", "in", "a", "dramatic", "decrease", "in", "immunoglobulin", "production"], "h": {"id": "C2698304", "name": "C2698304#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [8, 9]}}
{"token": ["By", "using", "previously", "constructed", "composite", "C1414404#ent", "<e1>", "and", "astrocyte-specific", "promoters", "in", "this", "C1520007#ent", "<e2>", "sustained", "transgene", "expressions", "could", "be", "achieved", "in", "human", "neuronal", "and", "glial", "cell", "lines", "but", "not", "in", "the", "correspondent", "rodent", "cell", "lines"], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1520007", "name": "C1520007#ent", "pos": [12, 13]}}
{"token": ["C0037760#ent", "<e1>", "and", "quinidine", ",", "Ca(2+)-activated", "K+", "channel", "blockade", "by", "C0282138#ent", "<e2>", "or", "nifedipine", "."], "h": {"id": "C0037760", "name": "C0037760#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [10, 11]}}
{"token": ["A", "class", "of", "C0032405#ent", "<e1>", "PARP-1", ")", "inhibitors", ",", "the", "C4048284#ent", "<e2>", ",", "are", "presented", "in", "this", "text", "."], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [10, 11]}}
{"token": ["The", "major", "protein", "constituents", "of", "the", "filoviral", "envelope", "the", "C1334506#ent", "<e1>", "and", "the", "C0021699#ent", "<e2>"], "h": {"id": "C1334506", "name": "C1334506#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [13, 14]}}
{"token": ["C1859722#ent", "<e1>", "the", "association", "of", "C0003886#ent", "<e2>", ",", "renal", "tubular", "dysfunction", "cholestasis", ",", "is", "a", "rare", "genetic", "disorder"], "h": {"id": "C1859722", "name": "C1859722#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0003886", "name": "C0003886#ent", "pos": [5, 6]}}
{"token": ["C1859722#ent", "<e1>", "a", "rare", "disorder", "consisting", "of", "C0003886#ent", "<e2>", ",", "renal", "tubular", "acidosis", "cholestatic", "liver", "disease"], "h": {"id": "C1859722", "name": "C1859722#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0003886", "name": "C0003886#ent", "pos": [7, 8]}}
{"token": ["To", "describe", "the", "clinical", "phenotype", "in", "infants", "with", "C1859722#ent", "<e1>", "the", "association", "of", "C0003886#ent", "<e2>", ",", "renal", "tubular", "acidosis", "and", "cholestasis", "."], "h": {"id": "C1859722", "name": "C1859722#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0003886", "name": "C0003886#ent", "pos": [13, 14]}}
{"token": ["The", "interaction", "of", "various", "cholecystokinin", "(", "CCK", ")", "C0030956#ent", "<e1>", "with", "the", "C1418370#ent", "<e2>", "PK-I", ")", "of", "cyclic", "AMP", "protein", "kinase", "(", "A-PK", ")", "has", "been", "studied", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418370", "name": "C1418370#ent", "pos": [12, 13]}}
{"token": ["LIGHT", "(", "lymphotoxin-like", "inducible", "protein", "that", "competes", "with", "glycoprotein", "D", "herpes", "virus", "entry", "on", "T", "cells", "is", "a", "C1420820#ent", "<e1>", "regulates", "T-cell", "activation", "causes", "experimental", "C0021390#ent", "<e2>"], "h": {"id": "C1420820", "name": "C1420820#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [25, 26]}}
{"token": ["C0937917#ent", "<e1>", "(", "BMP", ")", ",", "which", "is", "a", "highly", "effective", "C0003364#ent", "<e2>", "is", "a", "PGF(2)(alpha", ")", "analogue", "that", "inhibits", "both", "the", "PGD(2)", "11-ketoreductase", "PGH(2)", "9,11-endoperoxide", "reductase", "activities", "of", "PGFS", "."], "h": {"id": "C0937917", "name": "C0937917#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [11, 12]}}
{"token": ["C0937917#ent", "<e1>", ",", "a", "synthetic", "prostamide", "analogue", ",", "is", "a", "new", "C0003364#ent", "<e2>", "for", "the", "second-line", "treatment", "of", "open-angle", "glaucoma", "ocular", "hypertension"], "h": {"id": "C0937917", "name": "C0937917#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [11, 12]}}
{"token": ["This", "investigation", "examined", "the", "effectiveness", "of", "a", "serine", "protease", "inhibitor", "C0381874#ent", "<e1>", ")", "when", "used", "as", "a", "C0033613#ent", "<e2>", "ischemia", "."], "h": {"id": "C0381874", "name": "C0381874#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033613", "name": "C0033613#ent", "pos": [17, 18]}}
{"token": ["The", "feasibility", "of", "supporting", "a", "child", "with", "severe", "C1710605#ent", "<e1>", "from", "birth", "through", "age", "12", "with", "C0443121#ent", "<e2>", "derived", "from", "DDAVP-stimulated", "plasma", "exchange", "of", "a", "single", "dedicated", "donor", "is", "reported", "."], "h": {"id": "C1710605", "name": "C1710605#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0443121", "name": "C0443121#ent", "pos": [16, 17]}}
{"token": ["Using", "the", "invasive", "human", "melanoma", "cell", "line", "C0024375#ent", "<e1>", "as", "a", "model", "system", "we", "demonstrate", "that", "the", "C1412511#ent", "<e2>", "ARF6", ")", "GTPase", "is", "an", "important", "regulator", "of", "invadopodia", "formation", "and", "cell", "invasion"], "h": {"id": "C0024375", "name": "C0024375#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412511", "name": "C1412511#ent", "pos": [17, 18]}}
{"token": ["Using", "the", "invasive", "human", "melanoma", "cell", "line", "C0024375#ent", "<e1>", "as", "a", "model", "system", "we", "demonstrate", "that", "the", "ADP-ribosylation", "factor", "6", "C1412511#ent", "<e2>", ")", "GTPase", "is", "an", "important", "regulator", "of", "invadopodia", "formation", "and", "cell", "invasion"], "h": {"id": "C0024375", "name": "C0024375#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412511", "name": "C1412511#ent", "pos": [20, 21]}}
{"token": ["The", "current", "study", "examined", "the", "renoprotective", "effects", "of", "a", "selective", "C1100432#ent", "<e1>", "raloxifene", "(", "RAL", ")", ",", "in", "an", "experimental", "model", "C0011881#ent", "<e2>"], "h": {"id": "C1100432", "name": "C1100432#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [21, 22]}}
{"token": ["The", "protective", "actions", "of", "C1522428#ent", "<e1>", "abolished", "by", "prior", "C0242301#ent", "<e2>", "or", "by", "pretreatment", "of", "the", "animals", "with", "indomethacin", ",", "and", "were", "not", "shared", "by", "the", "nonapeptide", "fragment", "-", "171", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242301", "name": "C0242301#ent", "pos": [9, 10]}}
{"token": ["Protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "activation", "during", "C0010054#ent", "<e2>", "thought", "to", "be", "cardioprotective", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [8, 9]}}
{"token": ["To", "study", "the", "changes", "in", "activity", "of", "phosphatidylinositol", "4", "kinase", "PI", "4", "kinase", ",", "phosphatidylinositol", "4", "phosphate", "5", "kinase", "PIP", "5", "kinase", ")", "and", "protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "during", "C0010054#ent", "<e2>", "elucidate", "the", "relationship", "between", "phosphatidylinositol", "signal", "pathways", "prolonged", "C0010054#ent", "<e2>"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [31, 32]}}
{"token": ["Ischemic", "preconditioning", "IP", ")", "exerts", "cardioprotection", "through", "protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "activation", ",", "whereas", "C0010054#ent", "<e2>", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "mRNA", "expression", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [16, 17]}}
{"token": ["Fluvoxamine", "(", "8.2", "microM", ")", "and", "C0724555#ent", "<e1>", "(", "5.1", "microM", ")", "also", "inhibited", "C3887685#ent", "<e2>"], "h": {"id": "C0724555", "name": "C0724555#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [14, 15]}}
{"token": ["In", "these", "pathogenic", "processes", "C0004153#ent", "<e1>", ",", "angiotensin", "II", "in", "releasing", "growth", "factor", "cell", "proliferation", "hepatocyte", "growth", "factor", "C1524023#ent", "<e2>", ")", "participates", "in", "revascularization", "of", "the", "sclerotic", "lesion", "suggesting", "a", "candidate", "marker", "for", "C0004153#ent", "<e1>", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [18, 19]}}
{"token": ["C0268164#ent", "<e1>", "secondary", "to", "end-stage", "renal", "failure", "patients", "treated", "with", "long-term", "hemodialysis", "can", "present", "with", "C0029166#ent", "<e2>", "resemble", "those", "of", "gout", ",", "pseudogout", ",", "and", "apatite", "deposition", "disease"], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [15, 16]}}
{"token": ["We", "present", "two", "cases", "of", "C0268164#ent", "<e1>", "and", "describe", "the", "C0029166#ent", "<e2>", "this", "condition", "and", "their", "treatment", "."], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [10, 11]}}
{"token": ["Approximately", "40", "-", "70", "%", "of", "tumour", "cells", "C3538699#ent", "<e1>", "detected", "by", "a", "panel", "of", "antibodies", "monomorphic", ",", "or", "framework", ",", "C0017355#ent", "<e2>", "antigenic", "determinants"], "h": {"id": "C3538699", "name": "C3538699#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [21, 22]}}
{"token": ["Whereas", "C3538699#ent", "<e1>", "classical", "HLA-A", "and", "C0017355#ent", "<e2>", "undermethylated", "in", "both", "cytotrophoblast", "and", "syncytiotrophoblast", ",", "they", "are", "clearly", "transcribed", "in", "the", "former", "but", "minimally", "transcribed", "in", "the", "latter", "subpopulation", "."], "h": {"id": "C3538699", "name": "C3538699#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [6, 7]}}
{"token": ["Pituitary", "adenylate", "cyclase", "activating", "peptide", "38", "(", "C1412228#ent", "<e1>", "38", ")", "displays", "several", "biologic", "activities", "to", "C0600260#ent", "<e2>"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600260", "name": "C0600260#ent", "pos": [16, 17]}}
{"token": ["This", "C1417819#ent", "<e1>", "effect", "resulted", "in", "significant", "and", "sustained", "Ras-independent", "activation", "of", "C0812215#ent", "<e2>", "by", "PMA", "and", "H2O2", "."], "h": {"id": "C1417819", "name": "C1417819#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [12, 13]}}
{"token": ["Inhibition", "of", "a", "Src", "family", "tyrosine", "kinase", "C1417819#ent", "<e1>", "appears", "to", "alleviate", "this", "tyrosine", "kinase-mediated", "inhibition", "C0812215#ent", "<e2>", "and", "allow", "activating", "modification(s", ")", "of", "C0812215#ent", "<e2>", "to", "proceed", "."], "h": {"id": "C1417819", "name": "C1417819#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [16, 17]}}
{"token": ["We", "report", "a", "45-year-old", "Chinese", "man", "with", "CML", "and", "chronic", "hepatitis", "B", "virus", "infection", "on", "C0935989#ent", "<e1>", "treatment", ",", "presenting", "with", "herpetic", "rash", "and", "C0085605#ent", "<e2>"], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [24, 25]}}
{"token": ["Here", ",", "we", "show", "that", "C0209328#ent", "<e1>", "a", "key", "role", "in", "controlling", "C0669365#ent", "<e2>", "and", "regulated", "hormone", "secretion", "from", "mouse", "pituitary", "corticotrope", "(", "AtT20", ")", "cells", "."], "h": {"id": "C0209328", "name": "C0209328#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}}
{"token": ["C0209328#ent", "<e1>", "is", "a", "large", "GTPase", "residing", "within", "similar", "membrane", "compartments", "C0669365#ent", "<e2>", "."], "h": {"id": "C0209328", "name": "C0209328#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["A", "C0769345#ent", "<e1>", "separase", ",", "cleaves", "the", "cohesin", "subunit", "C2985427#ent", "<e2>", "and", "dissolves", "cohesion", "between", "sister", "chromatids", "initiating", "their", "separation", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2985427", "name": "C2985427#ent", "pos": [9, 10]}}
{"token": ["The", "map", "position", "the", "GRL", "locus", ",", "which", "was", "consistent", "with", "somatic", "cell", "hybrid", "5q-", "analyses", ",", "was", "telomeric", "to", "GMCSF", "and", "C1427959#ent", "<e1>", "to", "CSF1R/PDGFR", ",", "near", "C1705967#ent", "<e2>", "."], "h": {"id": "C1427959", "name": "C1427959#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1705967", "name": "C1705967#ent", "pos": [28, 29]}}
{"token": ["The", "general", "advantages", "of", "the", "yeast", "expression", "system", "make", "the", "described", "C0034861#ent", "<e1>", "candidate", "vaccines", "against", "C0375024#ent", "<e2>"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0375024", "name": "C0375024#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "it", "is", "suggested", "that", "immunostaining", "of", "skeletal", "muscle", "antibodies", "for", "C1422672#ent", "<e1>", "mitochondria", "is", "useful", "to", "corroborate", "a", "diagnosis", "of", "C1744687#ent", "<e2>", "."], "h": {"id": "C1422672", "name": "C1422672#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1744687", "name": "C1744687#ent", "pos": [22, 23]}}
{"token": ["Therapeutic", "strategies", "local", "C0017789#ent", "<e1>", "concentration", "and", "mitochondrial", "injury", "C0178540#ent", "<e2>", "may", "be", "relevant", "to", "human", "disorders", "associated", "with", "excitotoxicity", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0178540", "name": "C0178540#ent", "pos": [9, 10]}}
{"token": ["The", "secondary", "elevation", "CSF", "C0017789#ent", "<e1>", "at", "6", "h", "of", "recovery", "from", "2", "h", "of", "C0178540#ent", "<e2>", "occurs", "coincident", "with", "the", "onset", "of", "tissue", "necrosis", "seen", "histologically", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0178540", "name": "C0178540#ent", "pos": [15, 16]}}
{"token": ["C0072916#ent", "<e1>", "did", "not", "significantly", "improve", "any", "symptom", "of", "C0152020#ent", "<e2>", "relative", "to", "baseline", "or", "to", "placebo", "."], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0152020", "name": "C0152020#ent", "pos": [9, 10]}}
{"token": ["Treatment", "of", "gastric", "incontinence", ",", "almost", "exclusively", ",", "on", "dietary", "measures", "but", "several", "drugs", ",", "such", "as", "metoclopramide", ",", "domperidone", "and", "C0072916#ent", "<e1>", ",", "are", "available", "to", "treat", "C0152020#ent", "<e2>"], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0152020", "name": "C0152020#ent", "pos": [28, 29]}}
{"token": ["In", "the", "present", "study", "we", "have", "identified", "the", "C1333497#ent", "<e1>", "a", "major", "heparan", "sulfate", "proteoglycan", "C2987155#ent", "<e2>", ")", "in", "embryonic", "chick", "brain", "."], "h": {"id": "C1333497", "name": "C1333497#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [15, 16]}}
{"token": ["Autoimmune", "polyglandular", "disease", "type", "I", "(", "APECED", ")", "is", "an", "C0004364#ent", "<e1>", "MIM", "240300", ")", "characterized", "by", "hypoparathyroidism", ",", "C0001403#ent", "<e2>", "and", "chronic", "mucocutaneous", "candidiasis"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "the", "soluble", "antibody", "bound", "with", "similar", "three-dimensional", "affinity", "to", "surface-anchored", "P-selectin", "or", "C1419941#ent", "<e1>", "constructs", "regardless", "of", "carrier", "C0427008#ent", "<e2>", "and", "microtopology", "."], "h": {"id": "C1419941", "name": "C1419941#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0427008", "name": "C0427008#ent", "pos": [21, 22]}}
{"token": ["The", "main", "clinical", "features", "were", "C0152164#ent", "<e1>", "wailing", ",", "blindness", ",", "megalocephaly", ",", "convulsions", ",", "C0023380#ent", "<e2>", ",", "and", "coma", "."], "h": {"id": "C0152164", "name": "C0152164#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "enhanced", "expression", "of", "C1452441#ent", "<e1>", "in", "RAN-treated", "rats", "and", "its", "target", "C1417679#ent", "<e2>", "in", "LPS/RAN-treated", "rats", "suggests", "that", "p38/MAPKAPK-2", "signaling", "a", "regulation", "point", "for", "enhancement", "of", "LPS-induced", "gene", "expression", "RAN", "."], "h": {"id": "C1452441", "name": "C1452441#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["The", "purification", "fold", "of", "C0031727#ent", "<e1>", "DEA", "kinase", "different", "from", "each", "other", "and", "from", "that", "of", "C1872855#ent", "<e2>", "ethanolamine", "kinase"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1872855", "name": "C1872855#ent", "pos": [16, 17]}}
{"token": ["Jejunoileal", "bypass", "morbid", "obesity", "been", "associated", "with", "variety", "of", "long-term", "adverse", "sequelae", "including", "excess", "diarrhea", ",", "C3536863#ent", "<e1>", "imbalance", ",", "kidney", "dysfunction", "liver", "abnormalities", "and", "C0162323#ent", "<e2>", "."], "h": {"id": "C3536863", "name": "C3536863#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0162323", "name": "C0162323#ent", "pos": [25, 26]}}
{"token": ["We", "have", "shown", "recently", "that", "its", "cytotoxic", "signaling", "mediated", "via", "membrane-associated", "C1705637#ent", "<e1>", "and", "is", "dependent", "on", "decrease", "in", "intracellular", "pH", "(", "C1704947#ent", "<e2>", ")", "to", "6.5", "."], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [22, 23]}}
{"token": ["Rat", "gro/melanoma", "C1332817#ent", "<e1>", "a", "dimer", "composed", "of", "two", "identical", "C0599220#ent", "<e2>", "."], "h": {"id": "C1332817", "name": "C1332817#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [10, 11]}}
{"token": ["There", "was", "a", "significant", "correlation", "between", "the", "debrisoquine", "to", "C3887685#ent", "<e1>", "beta-adrenoceptor", "blockade", "h", "after", "dosing", "with", "C0087093#ent", "<e2>", "(", "rs", "=", "0.66", ",", "P", "less", "than", "0.05", ")", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [9, 10]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0087093", "name": "C0087093#ent", "pos": [17, 18]}}
{"token": ["Two", "genes", ",", "C3889652#ent", "<e1>", "and", "TEF2", ",", "encode", "the", "C1414270#ent", "<e2>", "the", "yeast", "Saccharomyces", "cerevisiae"], "h": {"id": "C3889652", "name": "C3889652#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414270", "name": "C1414270#ent", "pos": [10, 11]}}
{"token": ["C1332381#ent", "<e1>", "is", "required", "for", "protein", "stability", "C0079427#ent", "<e2>", "BRCA1", ",", "which", "depend", "on", "the", "ubiquitin", "ligase", "of", "the", "BRCA1-BARD1", "heterodimer"], "h": {"id": "C1332381", "name": "C1332381#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "suggest", "that", "C1332381#ent", "<e1>", "may", "regulate", "the", "transcriptional", "activities", "p53", "as", "C0079427#ent", "<e2>"], "h": {"id": "C1332381", "name": "C1332381#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [13, 14]}}
{"token": ["BARD1", "(", "C1332381#ent", "<e1>", "is", "a", "C0079427#ent", "<e2>", "protein", "product", "with", "BRCA1", ",", "and", "in", "which", "rare", "somatic", "and", "germline", "mutations", "been", "reported", "in", "breast", ",", "uterine", ",", "and", "endometrial", "cancers"], "h": {"id": "C1332381", "name": "C1332381#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [6, 7]}}
{"token": ["In", "conclusion", ",", "elevated", "C1415377#ent", "<e1>", "activation", ",", "glucose", "uptake", "and", "C1420175#ent", "<e2>", "expression", "enhance", "glycogen", "resynthesis", "muscles", "with", "low", "glycogen"], "h": {"id": "C1415377", "name": "C1415377#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [11, 12]}}
{"token": ["Recombination", "data", "show", "that", "C1413038#ent", "<e1>", "is", "located", "about", "37", "map", "units", "the", "C1333677#ent", "<e2>", "structural", "gene", "the", "chromosome", "1S"], "h": {"id": "C1413038", "name": "C1413038#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333677", "name": "C1333677#ent", "pos": [13, 14]}}
{"token": ["The", "ATP-induced", "increase", "in", "DA", "was", "inhibited", "by", "adding", "suramin", ",", "a", "C2936574#ent", "<e1>", "and", "reactive", "blue", "2", "a", "C2936563#ent", "<e2>", "but", "not", "inhibited", "by", "xanthine", "amine", "congener", "an", "adenosine", "receptor", "antagonist"], "h": {"id": "C2936574", "name": "C2936574#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2936563", "name": "C2936563#ent", "pos": [19, 20]}}
{"token": ["FN-induced", "cell", "spreading", "a", "sustained", "increase", "in", "Lyn", "activity", "with", "coincidental", "kinetics", "and", "the", "activation", "of", "C1442804#ent", "<e1>", "was", "also", "suppressed", "by", "overexpression", "of", "C1334485#ent", "<e2>", "but", "not", "a", "Chk", "mutant", "the", "SH3", "domain"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334485", "name": "C1334485#ent", "pos": [24, 25]}}
{"token": ["The", "Bacillus", "subtilis", "histidine", "kinase-response", "regulator", "pair", "controls", "the", "expression", "of", "C0017337#ent", "<e1>", "encoding", "degradative", "enzymes", "as", "levansucrase", "(", "C2828027#ent", "<e2>", ")", "and", "of", "C0017337#ent", "<e1>", "involved", "in", "genetic", "competence"], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["SurB", "and", "SurC", "shared", "97", "%", "and", "43", "%", "amino", "acid", "identity", "with", "the", "corresponding", "SacB", "and", "SacC", "proteins", "of", "Bacillus", "subtilis", "whose", "C2828027#ent", "<e1>", "and", "sacC", "C0017337#ent", "<e2>", "are", "organised", "very", "differently", "."], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [27, 28]}}
{"token": ["Transcription", "of", "C2828027#ent", "<e1>", ",", "yveB", "and", "yveA", ",", "three", "clustered", "C0017337#ent", "<e2>", "on", "the", "Bacillus", "subtilis", "chromosome", ",", "is", "simultaneously", "induced", "by", "sucrose", "."], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["The", "acylation", "of", "cyclic", "and", "C0005100#ent", "<e1>", "such", "as", "cyclohexanol", "or", "C0031398#ent", "<e2>", ",", "further", "underlines", "the", "unspecific", "character", "of", "this", "enzyme", "."], "h": {"id": "C0005100", "name": "C0005100#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031398", "name": "C0031398#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "cold", "lymphocytotoxins", "in", "the", "present", "work", ",", "have", "been", "frequently", "detected", "in", "C0852336#ent", "<e1>", "cold", "agglutinins", "and", "in", "patients", "having", "C0162538#ent", "<e2>", "."], "h": {"id": "C0852336", "name": "C0852336#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0162538", "name": "C0162538#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "C3540559#ent", "<e1>", ",", "Hir2", ",", "Hir3", ",", "and", "Hpc2", "proteins", "a", "stable", "C1416586#ent", "<e2>", "repressor", "complex", "."], "h": {"id": "C3540559", "name": "C3540559#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416586", "name": "C1416586#ent", "pos": [17, 18]}}
{"token": ["This", "method", "has", "been", "used", "to", "extract", "the", "native", "trimer", "of", "C0755857#ent", "<e1>", ",", "the", "major", "C0028978#ent", "<e2>", ",", "in", "a", "large", "scale", ",", "for", "structure-function", "studies", "."], "h": {"id": "C0755857", "name": "C0755857#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [16, 17]}}
{"token": ["the", "release", "of", "[3H]serotonin", "and", "[14C]arachidonate", "from", "platelets", "stimulated", "with", "C0914069#ent", "<e1>", "not", "affected", "by", "C0021246#ent", "<e2>", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [15, 16]}}
{"token": ["Both", "the", "toxicity", "and", "the", "vasopermeability", "changes", "induced", "by", "endotoxin", "alone", "were", "blocked", "by", "the", "C0914069#ent", "<e1>", "PAF", ")", "antagonist", "BN52021", ",", "C0021246#ent", "<e2>", "or", "the", "dual", "cyclo-oxygenase/lipoxygenase", "inhibitor", "BW755C", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [22, 23]}}
{"token": ["Compared", "with", "several", "other", "C0003211#ent", "<e1>", ",", "such", "as", "indomethacin", ",", "loxoprofen", "and", "C0700583#ent", "<e2>", ",", "zaltoprofen", "most", "potently", "inhibits", "bradykinin-enhancement", "of", "capsaicin-induced", "45Ca2", "+", "uptake", "into", "DRG", "neurons", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [13, 14]}}
{"token": ["The", "antiphospholipid", "syndrome", "no", "relationship", "to", "the", "class", "of", "C4053959#ent", "<e1>", "is", "accompanied", "by", "more", "frequent", "and", "greater", "hypertension", "and", "greater", "C0242528#ent", "<e2>", "and", "interstitial", "fibrosis", "and", "is", "associated", "with", "outcomes", "than", "C4053959#ent", "<e1>", "antiphospholipid", "syndrome"], "h": {"id": "C0242528", "name": "C0242528#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [9, 10]}}
{"token": ["These", "data", "suggest", "that", "C3887685#ent", "<e1>", "is", "involved", "in", "the", "metabolism", "of", "C0008286#ent", "<e2>", "to", "7-hydroxychlorpromazine", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [4, 5]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [12, 13]}}
{"token": ["The", "fixed", "low-dose", "combination", "of", "the", "ACE", "inhibitor", "C0070426#ent", "<e1>", "and", "the", "C0012802#ent", "<e2>", "indapamide", "has", "been", "evaluated", "in", "the", "management", "of", "patients", "with", "mild", "to", "moderate", "hypertension", "."], "h": {"id": "C0070426", "name": "C0070426#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012802", "name": "C0012802#ent", "pos": [12, 13]}}
{"token": ["Neutrophil-related", "inflammation", "associated", "with", "decrease", "in", "C0206744#ent", "<e1>", "reflect", "the", "progression", "of", "C0876973#ent", "<e2>", "nodular", "bronchiectasis"], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0876973", "name": "C0876973#ent", "pos": [12, 13]}}
{"token": ["The", "patient", "presented", "with", "virus-associated", "hemophagocytic", "syndrome", "VAHS", ")", "and", "later", "had", "C0008513#ent", "<e1>", ",", "bronchiectasis", ",", "and", "C0086438#ent", "<e2>", "develop", "."], "h": {"id": "C0008513", "name": "C0008513#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086438", "name": "C0086438#ent", "pos": [18, 19]}}
{"token": ["These", "data", "suggest", "that", ",", "whereas", "both", "OAT1", "and", "C1412610#ent", "<e1>", "probably", "transport", "DMPSH", ",", "C0041738#ent", "<e2>", "transport", "may", "be", "limited", "to", "C1412610#ent", "<e1>", "."], "h": {"id": "C1412610", "name": "C1412610#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041738", "name": "C0041738#ent", "pos": [15, 16]}}
{"token": ["Dextran", "magnetite", "C3250443#ent", "<e1>", ")", "is", "a", "potential", "C0311284#ent", "<e2>", "contrast", "agent", "superparamagnetic", "properties", "."], "h": {"id": "C3250443", "name": "C3250443#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0311284", "name": "C0311284#ent", "pos": [8, 9]}}
{"token": ["Glycosaminoglycan", "(", "C0017346#ent", "<e1>", ")", "infiltration", "of", "the", "skin", "is", "a", "feature", "of", "C3831153#ent", "<e2>", ",", "hypothyroidism", ",", "pretibial", "myxedema", "scleromyxedema", ",", "and", "scleredema", "."], "h": {"id": "C0017346", "name": "C0017346#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [13, 14]}}
{"token": ["Enzymatic", "induction", "produced", "by", "treating", "rats", "with", "phenobarbital", "(", "to", "induce", "CYP2B1/2", ")", ",", "beta-naphthoflavone", "(", "to", "induce", "CYP1A1/2", ")", ",", "or", "C0034242#ent", "<e1>", "(", "to", "induce", "C3887686#ent", "<e2>", ")", "."], "h": {"id": "C0034242", "name": "C0034242#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [27, 28]}}
{"token": ["Rats", "were", "treated", "with", "C0034242#ent", "<e1>", "to", "induce", "C3887686#ent", "<e2>", "and", "hepatocytes", "prepared", "from", "periportal", "or", "pericentral", "zones", "of", "the", "livers", "by", "the", "digitonin-collagenase", "procedure", "."], "h": {"id": "C0034242", "name": "C0034242#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [8, 9]}}
{"token": ["C0034242#ent", "<e1>", "treatment", "to", "induce", "cytochrome", "P-450", "2E1", "C3887686#ent", "<e2>", ")", "was", "recently", "shown", "to", "cause", "liver", "injury", "ob/ob", "mice", "not", "in", "lean", "mice", "."], "h": {"id": "C0034242", "name": "C0034242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [8, 9]}}
{"token": ["C0034242#ent", "<e1>", "can", "induce", "C3887686#ent", "<e2>", "and", "2A5", ",", "which", "produce", "reactive", "oxygen", "species", "ROS", ")", "."], "h": {"id": "C0034242", "name": "C0034242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [4, 5]}}
{"token": ["In", "these", "patients", "thoracic", "images", "demonstrated", "parenchymal", "nodules", "consolidations", "with", "cavitation", ",", "C1881236#ent", "<e1>", "mediastinal", "or", "C0497156#ent", "<e2>", "and", "isolated", "stenoses", "of", "the", "larynx", "or", "tracheobronchial", "tree"], "h": {"id": "C1881236", "name": "C1881236#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0497156", "name": "C0497156#ent", "pos": [16, 17]}}
{"token": ["Strains", "of", "Bacillus", "subtilis", "for", "C0031727#ent", "<e1>", "fruA", ")", ",", "fructose-1-phosphate", "kinase", "fruB", ")", ",", "C0060764#ent", "<e2>", "(", "frucC", ")", "have", "been", "tested", "for", "their", "catabolism", "of", "sorbitol", "and", "fructose", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0060764", "name": "C0060764#ent", "pos": [15, 16]}}
{"token": ["This", "point", "was", "used", "to", "crudely", "dock", "the", "solution", "structure", "C1416453#ent", "<e1>", "onto", "the", "LRR", "model", "of", "C1424898#ent", "<e2>", ",", "allowing", "the", "prediction", "of", "the", "C1416453#ent", "<e1>", "Trp-B27", "binding", "site"], "h": {"id": "C1424898", "name": "C1424898#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416453", "name": "C1416453#ent", "pos": [10, 11]}}
{"token": ["This", "study", "defines", "the", "pharmacologic", "characteristics", "of", "LGR7", "and", "C1424898#ent", "<e1>", ",", "the", "receptors", "for", "H2", "relaxin", "C1416453#ent", "<e2>", "respectively", ",", "and", "determines", "the", "relative", "activity", "of", "relaxin-related", "peptides", "."], "h": {"id": "C1424898", "name": "C1424898#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416453", "name": "C1416453#ent", "pos": [17, 18]}}
{"token": ["This", "pattern", "of", "mild", "hepatotoxicity", "in", "patients", "with", "early", "C0009952#ent", "<e1>", "reactions", "to", "C3540782#ent", "<e2>", "contrasts", "with", "the", "later", "more", "serious", "viral", "hepatitis-like", "illness", "due", "to", "the", "drug", "."], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540782", "name": "C3540782#ent", "pos": [13, 14]}}
{"token": ["There", "were", "no", "relationships", "between", "bax", ",", "bcl-2", ",", "C1332416#ent", "<e1>", ",", "p53", ",", "fas", ",", "and", "C0079068#ent", "<e2>", "with", "EBV", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [17, 18]}}
{"token": ["EBV-EBER", ",", "lmp-1", ",", "ki-67", ",", "bcl-2", ",", "C1332416#ent", "<e1>", ",", "Bax", ",", "fas", ",", "C0079068#ent", "<e2>", ",", "and", "p53", ",", "and", "apoptotic", "index", "analyzed", "in", "63", "pediatric", "Hodgkin", "lymphoma", "cases", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [15, 16]}}
{"token": ["As", "often", "observed", "in", "patients", "with", "C0017920#ent", "<e1>", ",", "this", "patient", "has", "multiple", "risk", "factors", "C0003850#ent", "<e2>", "including", "hyperlipidemia", ",", "hypertension", ",", "glucose", "intolerance", "insulin", "resistance", "and", "chronic", "kidney", "disease"], "h": {"id": "C0017920", "name": "C0017920#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [15, 16]}}
{"token": ["The", "presence", "of", "C4025182#ent", "<e1>", "associated", "with", "higher", "incidence", "of", "follow-up", "cardiac", "events", "patients", "with", "C3275121#ent", "<e2>", "incomplete", "revascularization", "(", "52", "%", "versus", "33", "%", ";", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [15, 16]}}
{"token": ["The", "C4025182#ent", "<e1>", "ST-segment", "responses", "were", "correlated", "with", "the", "presence", "of", "C3275121#ent", "<e2>", "the", "presence", "of", "advanced", "left", "ventricular", "wall", "motion", "abnormalities", "LVWMA", ")", ",", "and", "ejection", "fraction"], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [11, 12]}}
{"token": ["Serum", "C0812308#ent", "<e1>", "concentration", "increases", "in", "C1290884#ent", "<e2>"], "h": {"id": "C0812308", "name": "C0812308#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [6, 7]}}
{"token": ["Asymptomatic", ",", "transient", "elevations", "of", "C0002594#ent", "<e1>", "levels", "may", "occur", "in", "patients", "receiving", "C0025741#ent", "<e2>", "."], "h": {"id": "C0002594", "name": "C0002594#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025741", "name": "C0025741#ent", "pos": [13, 14]}}
{"token": ["An", "attempt", "is", "made", "to", "demonstrate", "a", "relationship", "between", "changes", "in", "arterial", "blood", "pressure", "C0038317#ent", "<e1>", "gonadotrophins", "and", "mineralocorticoids", "in", "30-", "to", "55-year-old", "females", "with", "C0155583#ent", "<e2>", "employed", "in", "textile", "industry", "Cheboksary", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [25, 26]}}
{"token": ["We", "report", "the", "measurement", "of", "both", "C0038317#ent", "<e1>", "in", "the", "urine", "of", "patients", "with", "C0155583#ent", "<e2>"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [14, 15]}}
{"token": ["The", "C0271408#ent", "<e1>", "was", "studied", "in", "50", "eyes", "with", "C0035328#ent", "<e2>", "RBVO", ")", "and", "compared", "to", "an", "age-matched", "control", "group", "."], "h": {"id": "C0271408", "name": "C0271408#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035328", "name": "C0035328#ent", "pos": [9, 10]}}
{"token": ["To", "define", "the", "role", "of", "C1413175#ent", "<e1>", "C2314882#ent", "<e2>", "the", "ICP0", "binding", "site", "for", "C1413175#ent", "<e1>", "mapped", "and", "mutagenized", "by", "substitution", "of", "aspartic", "acid", "codon", "with", "the", "alanine", "codon"], "h": {"id": "C2314882", "name": "C2314882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413175", "name": "C1413175#ent", "pos": [5, 6]}}
{"token": ["A", "total", "of", "30", "%", "(", "74", "of", "250", ")", "of", "C0476281#ent", "<e1>", "patients", "had", "a", "documented", "history", "of", "C1504769#ent", "<e2>", "."], "h": {"id": "C0476281", "name": "C0476281#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [19, 20]}}
{"token": ["To", "investigate", "the", "potential", "role", "of", "lysosomes", "in", "C0023890#ent", "<e1>", ",", "the", "activity", "of", "C0085078#ent", "<e2>", "analyzed", "in", "rats", "with", "C0023890#ent", "<e1>", "induced", "by", "bile-duct", "ligation"], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "the", "data", "of", "the", "present", "study", "indicate", "that", "CCK-8", "and", "carbachol", "activate", "C1377871#ent", "<e1>", "PLC-beta", "3", "respectively", ",", "whereas", "C1333714#ent", "<e2>", "activates", "both", "C1377871#ent", "<e1>", "PLC-beta", "3"], "h": {"id": "C1377871", "name": "C1377871#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [22, 23]}}
{"token": ["A", "unique", "case", "of", "a", "male", "infant", "with", "C0403397#ent", "<e1>", "by", "pulmonary", "and", "C0004030#ent", "<e2>", "described", "."], "h": {"id": "C0403397", "name": "C0403397#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [13, 14]}}
{"token": ["Risk", "factors", "marrow", "aplasia", "extensive", "prior", "therapy", ",", "prior", "C3540781#ent", "<e1>", ",", "cumulative", "toxicity", "from", "C0137098#ent", "<e2>", ",", "and", "abnormal", "liver", "function", "tests"], "h": {"id": "C3540781", "name": "C3540781#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0137098", "name": "C0137098#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "we", "report", "the", "in", "vitro", "differentiation", "of", "common", "marmoset", "(", "CM", ")", "(", "Callithrix", "jacchus", "C1849394#ent", "<e1>", "into", "hematopoietic", "cells", "exogenous", "gene", "transfer", "C0266999#ent", "<e2>", "lentiviral", "vectors", "."], "h": {"id": "C1849394", "name": "C1849394#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0266999", "name": "C0266999#ent", "pos": [25, 26]}}
{"token": ["C1824795#ent", "<e1>", "was", "first", "identified", "C1516876#ent", "<e2>", "as", "a", "translational", "repressor", "GCN4", "."], "h": {"id": "C1824795", "name": "C1824795#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [5, 6]}}
{"token": ["C0012315#ent", "<e1>", "equipotent", "to", "nifedipine", "and", "C0051696#ent", "<e2>", "in", "vitro"], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [6, 7]}}
{"token": ["We", "characterized", "the", "occupancy", "of", "C0012315#ent", "<e1>", "(", "DHP", ")", "calcium", "antagonist", "receptors", "by", "C0051696#ent", "<e2>", "in", "spontaneously", "hypertensive", "rats", "(", "SHR", ")", "in", "relation", "to", "its", "pharmacokinetics", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [14, 15]}}
{"token": ["Both", "C1704968#ent", "<e1>", "and", "p16", "genes", "homozygously", "deleted", "in", "4", "of", "23", "acute/lymphomatous", "C0054871#ent", "<e2>", "(", "17", "%", ")", "."], "h": {"id": "C1704968", "name": "C1704968#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [13, 14]}}
{"token": ["Neither", "homozygous", "nor", "hemizygous", "deletions", "of", "the", "C1704968#ent", "<e1>", "found", "in", "chronic", "C0054871#ent", "<e2>", "."], "h": {"id": "C1704968", "name": "C1704968#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [12, 13]}}
{"token": ["C0007804#ent", "<e1>", "and", "NaS", "at", "1", "mM", "did", "not", "induce", "C1709384#ent", "<e2>", "cleavage", "or", "caspase-3", "and", "at", "5", "mM", ",", "C0007804#ent", "<e1>", "but", "not", "NaS", "increased", "apoptosis", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1709384", "name": "C1709384#ent", "pos": [10, 11]}}
{"token": ["To", "establish", "a", "cell", "line", "expressing", "enhanced", "levels", "of", "C1364818#ent", "<e1>", "beta-APP", ")", ",", "we", "constructed", "plasmid", "C0011522#ent", "<e2>", "expressing", "beta-APP-751", "mRNA", "and", "transfected", "them", "into", "COS-1", "cells"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [17, 18]}}
{"token": ["The", "increase", "in", "airway", "resistance", ",", "correlated", "with", "the", "IgE", "titer", "and", "the", "dose", "of", "antigen", ",", "was", "inhibited", "by", "C0012694#ent", "<e1>", "DSCG", ")", "or", "by", "C0002575#ent", "<e2>", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [26, 27]}}
{"token": ["1", "The", "inhibitory", "effects", "of", "C0012694#ent", "<e1>", "SCG", ")", "and", "C0002575#ent", "<e2>", "on", "antigen-induced", "bronchial", "anaphylaxis", "in", "guinea-pigs", ",", "actively", "sensitized", "according", "to", "different", "regimens", ",", "were", "examined", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [10, 11]}}
{"token": ["Long-term", "treatment", "with", "C0012694#ent", "<e1>", ",", "but", "not", "with", "C0002575#ent", "<e2>", ",", "reversed", "this", "decreased", "reactivity", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [9, 10]}}
{"token": ["This", "C0039082#ent", "<e1>", "is", "currently", "designated", "HIV-1-associated", "cognitive/motor", "complex", "was", "originally", "termed", "the", "C0001849#ent", "<e2>", "and", "for", "simplicity", ",", "is", "called", "AIDS", "dementia", "in", "this", "review", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001849", "name": "C0001849#ent", "pos": [13, 14]}}
{"token": ["The", "most", "common", "C0039082#ent", "<e1>", "a", "dementing", "illness", "to", "as", "the", "C0001849#ent", "<e2>", "complex", ",", "in", "which", "motor", "and", "cognitive", "changes", "also", "be", "seen", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001849", "name": "C0001849#ent", "pos": [11, 12]}}
{"token": ["These", "data", "do", "not", "exclude", "the", "existence", "of", "additional", "C0022173#ent", "<e1>", "of", "sarcolemmal", "C1415793#ent", "<e2>", "that", "may", "have", "been", "removed", "during", "isolation", "of", "sarcolemmal", "membranes"], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [13, 14]}}
{"token": ["Using", "fluorescence", "to", "monitor", "transport", "activity", "we", "characterized", "the", "accumulation", "of", "C0949665#ent", "<e1>", "and", "tetracyclines", "in", "cultured", "human", "gingival", "fibroblast", "C0872351#ent", "<e2>", "."], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [20, 21]}}
{"token": ["The", "present", "study", "suggests", "that", "hemodynamic", "forces", "exerted", "by", "pulsatile", "coronary", "circulation", "termed", "C0406587#ent", "<e1>", ",", "might", "affect", "the", "evolution", "of", "C0004153#ent", "<e2>", "within", "the", "angulated", "vascular", "curvature", "."], "h": {"id": "C0406587", "name": "C0406587#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [21, 22]}}
{"token": ["The", "C0035064#ent", "<e1>", "were", "also", "additive", "with", "C0733688#ent", "<e2>", "in", "reducing", "tumor", "cell", "number", "soft-agar", "colony", "growth", "and", "DNA", "synthesis", "in", "producing", "DNA", "strand", "scission", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0733688", "name": "C0733688#ent", "pos": [7, 8]}}
{"token": ["We", "found", "out", "that", "coexistent", "antinuclear", "antibodies", "antibodies", "to", "Sm", ",", "U1-nRNP", ",", "Ro", "and", "La", ",", "except", "in", "D-penicillamine", "induced", "C0409979#ent", "<e1>", "were", "most", "specific", "for", "C0009782#ent", "<e2>"], "h": {"id": "C0409979", "name": "C0409979#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [27, 28]}}
{"token": ["The", "incorporation", "rate", "phosphatidylinositol", "and", "C1450468#ent", "<e1>", "was", "not", "influenced", "by", "C0007710#ent", "<e2>", "."], "h": {"id": "C1450468", "name": "C1450468#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007710", "name": "C0007710#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "enalaprilat", "(", "MK-422", ")", ",", "an", "C0003015#ent", "<e1>", "were", "compared", "to", "those", "of", "SCRIP", ",", "a", "C1960108#ent", "<e2>", "in", "experimentally", "induced", "left", "ventricular", "failure"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1960108", "name": "C1960108#ent", "pos": [19, 20]}}
{"token": ["Using", "partial", "amino", "acid", "sequence", "data", "derived", "from", "porcine", "methionyl", "aminopeptidase", "MetAP", ";", "methionine", "aminopeptidase", "C1423731#ent", "<e1>", "EC", "3.4.11.18", ",", "a", "full-length", "clone", "of", "the", "C1512488#ent", "<e2>", "human", "enzyme", "has", "been", "obtained", "."], "h": {"id": "C1423731", "name": "C1423731#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [25, 26]}}
{"token": ["Immunoprecipitations", "with", "antibodies", "to", "Jak2", "indicate", "that", "the", "C1335554#ent", "<e1>", "SHP-1", "is", "associated", "with", "kinase", "in", "cells", "exposed", "to", "C3539616#ent", "<e2>", "."], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [19, 20]}}
{"token": ["Phenobarbital", "and", "trimethadione", "elevated", "the", "threshold", "for", "all", "excitatory", "C3539946#ent", "<e1>", "tested", ",", "whereas", "valproate", "elevated", "the", "threshold", "for", "C0001473#ent", "<e2>", "and", "kainate", "seizures"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [19, 20]}}
{"token": ["The", "second", "part", "of", "the", "study", "consisted", "of", "a", "screen", "for", "the", "presence", "of", "the", "Y", "chromosome", "genes", "DBY", ",", "C1413303#ent", "<e1>", ",", "XKRY", ",", "eIF-1A", ",", "DAZ", "and", "C1538959#ent", "<e2>", "."], "h": {"id": "C1413303", "name": "C1413303#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1538959", "name": "C1538959#ent", "pos": [29, 30]}}
{"token": ["Idarubicin", ",", "mitoxantrone", ",", "C1271552#ent", "<e1>", ",", "homoharringtonine", ",", "2-chlorodeoxyadenosine", ",", "fludarabine", ",", "carboplatin", ",", "C0035339#ent", "<e2>", ",", "colony", "stimulating", "factors", "and", "interleukin-2", "are", "discussed", "."], "h": {"id": "C1271552", "name": "C1271552#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [15, 16]}}
{"token": ["Two", "minutes", "after", "the", "intravenous", "administration", "C0242531#ent", "<e1>", "0.25", "mg", "as", "a", "\"", "first", "dose", "\"", ",", "C0006266#ent", "<e2>", "and", "skin", "rashes", "."], "h": {"id": "C0242531", "name": "C0242531#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [17, 18]}}
{"token": ["During", "induction", "with", "thiopental", "plus", "C0242531#ent", "<e1>", "and", "on", "addition", "of", "C0242531#ent", "<e1>", ",", "C0006266#ent", "<e1>", "was", "induced", "within", "five", "minutes", "in", "each", "time", "."], "h": {"id": "C0242531", "name": "C0242531#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "IL-10-mediated", "down-regulation", "of", "C1366561#ent", "<e1>", "on", "B", "cells", "suggested", "to", "be", "involved", "in", "the", "C1565489#ent", "<e2>", "MS", "Tg", "mice", "in", "vivo"], "h": {"id": "C1366561", "name": "C1366561#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [16, 17]}}
{"token": ["Other", "complications", "associated", "with", "C0013743#ent", "<e1>", "hemoptysis", ",", "gout", ",", "C0856727#ent", "<e2>", ",", "hypertrophic", "osteoarthropathy", "and", "decreased", "renal", "function"], "h": {"id": "C0013743", "name": "C0013743#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [10, 11]}}
{"token": ["This", "study", "investigated", "whether", "C0010073#ent", "<e1>", "be", "a", "reason", "for", "elevated", "C3538828#ent", "<e2>", "in", "this", "patient", "population"], "h": {"id": "C0010073", "name": "C0010073#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538828", "name": "C3538828#ent", "pos": [11, 12]}}
{"token": ["Subsequently", ",", "the", "gene", "organization", "the", "A.", "acetabulum", "C1538472#ent", "<e1>", "was", "compared", "to", "those", "of", "the", "C1334043#ent", "<e2>", "100", "kb", "and", "21", "exons", ")", "and", "Caenorhabditis", "elegans", "5.1", "kb", "and", "18", "exons", ")", "genes", "."], "h": {"id": "C1538472", "name": "C1538472#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "present", "a", "crystallographic", "study", "the", "ion-binding", "properties", "of", "the", "C1538472#ent", "<e1>", "selectivity", "filter", "in", "the", "close", "C1334043#ent", "<e2>", "from", "Escherichia", "coli", "EcClC", ")", "."], "h": {"id": "C1538472", "name": "C1538472#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "lower", "concentrations", "of", "SM", "cause", "minor", "C1567710#ent", "<e1>", "activation", "and", ",", "especially", ",", "PARP-1", "cleavage", "by", "C0291573#ent", "<e2>", "ATP", "depletion", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [19, 20]}}
{"token": ["The", "most", "frequent", "cause", "of", "recurrence", "is", "C0017658#ent", "<e1>", ":", "Membrano-proliferative", "GN", "type", "II", ",", "C0027697#ent", "<e2>", "focal", "sclerosis", "frequently", "observed", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0027697", "name": "C0027697#ent", "pos": [15, 16]}}
{"token": ["Even", "high", "doses", "oestradiol", "during", "GnRH", "agonist", "treatment", "do", "not", "abolish", "C0005874#ent", "<e1>", ",", "whereas", "the", "alpha", "2-adrenergic", "agonists", "as", "clonidine", "and", "alpha-methyldopa", "abolish", "C0005874#ent", "<e1>", "during", "treatment", "with", "GnRH", "C0243192#ent", "<e1>", "."], "h": {"id": "C0005874", "name": "C0005874#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [30, 31]}}
{"token": ["Tumor", "expression", "of", "mRNA", "was", "amplified", "by", "PCR", "for", "p53", ",", "PIC1", ",", "c-myc", ",", "and", "C1515406#ent", "<e1>", "quantitated", ";", "and", "standardized", "to", "C0809246#ent", "<e2>", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0809246", "name": "C0809246#ent", "pos": [23, 24]}}
{"token": ["Consistent", "with", "causal", "role", "in", "gene", "silencing", "ES", "cells", "PcG", "target", "C1417679#ent", "<e1>", "were", "de-repressed", "in", "cells", "deficient", "for", "the", "PRC2", "component", "C1414269#ent", "<e2>", ",", "and", "were", "preferentially", "activated", "on", "induction", "of", "differentiation", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414269", "name": "C1414269#ent", "pos": [22, 23]}}
{"token": ["The", "underlying", "defect", "is", "a", "result", "of", "mutations", "in", "the", "C1412638#ent", "<e1>", "chromosome", "12q23", "-", "24", "that", "encodes", "for", "a", "C1567357#ent", "<e2>", "SERCA", "2", ")", "."], "h": {"id": "C1412638", "name": "C1412638#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1567357", "name": "C1567357#ent", "pos": [20, 21]}}
{"token": ["C0751383#ent", "<e1>", "CLN3", ")", "is", "characterized", "by", "progressive", "C0235946#ent", "<e2>"], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0235946", "name": "C0235946#ent", "pos": [8, 9]}}
{"token": ["Pregnancy-associated", "malaria", "PAM", ")", "is", "caused", "by", "Plasmodium", "falciparum-infected", "erythrocytes", "(", "IEs", ")", "that", "bind", "to", "chondroitin", "sulphate", "A", "C0751039#ent", "<e1>", ")", "in", "the", "placenta", "by", "C1420017#ent", "<e2>", "clonally", "variant", "surface", "antigens", "VSA", ")", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420017", "name": "C1420017#ent", "pos": [26, 27]}}
{"token": ["She", "presented", "with", "symptoms", "of", "C0744898#ent", "<e1>", "dyspnea", ",", "and", "early", "C0206062#ent", "<e2>"], "h": {"id": "C0744898", "name": "C0744898#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0206062", "name": "C0206062#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "patient", "who", "presented", "with", "progressive", "exertional", "dyspnoea", "C0744898#ent", "<e1>", "radiographic", "signs", "of", "C0206062#ent", "<e2>"], "h": {"id": "C0744898", "name": "C0744898#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0206062", "name": "C0206062#ent", "pos": [15, 16]}}
{"token": ["The", "nontranscriptional", "actions", "of", "C1705401#ent", "<e1>", "involve", "the", "rapid", "activation", "of", "protein", "kinases", "such", "as", "phosphatidylinositol-3", "kinase", "C0812228#ent", "<e2>", ",", "leading", "to", "the", "activation", "of", "endothelial", "nitric", "oxide", "synthase"], "h": {"id": "C1705401", "name": "C1705401#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [17, 18]}}
{"token": ["C1705401#ent", "<e1>", "activation", "by", "dexamethasone", "in", "normal", "mouse", "skin", "decreased", "C0812228#ent", "<e2>", "activity", "within", "minutes", ",", "whereas", "cotreatment", "with", "the", "GR", "antagonist", "RU486", "abolished", "dexamethasone", "action"], "h": {"id": "C1705401", "name": "C1705401#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [10, 11]}}
{"token": ["Most", "cases", "of", "bilateral", "simultaneous", "rupture", "occur", "in", "association", "with", "systemic", "disease", "i.e.", ",", "systemic", "lupus", "erythematosus", "C0027719#ent", "<e1>", ",", "diabetes", ",", "or", "C0020503#ent", "<e2>"], "h": {"id": "C0027719", "name": "C0027719#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020503", "name": "C0020503#ent", "pos": [23, 24]}}
{"token": ["In", "both", "cases", ",", "75", "-", "90", "%", "of", "the", "C2697656#ent", "<e1>", "could", "be", "released", "by", "treatment", "with", "C1335226#ent", "<e2>", "suggesting", "that", "it", "remains", "associated", "with", "glycosyl", "phosphatidylinositol-anchored", "CD14", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335226", "name": "C1335226#ent", "pos": [18, 19]}}
{"token": ["Total", "activities", "acid", "hydrolases", "liver", "of", "two", "patients", "with", "mucopolysaccharidosis", "are", "decreased", "for", "beta-galactosidase", ",", "alpha-galactosidase", ",", "and", "C3853627#ent", "<e1>", "total", "activities", "of", "four", "other", "C0020289#ent", "<e2>", "are", "normal", "or", "increased", "."], "h": {"id": "C3853627", "name": "C3853627#ent", "pos": [18, 19]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [25, 26]}}
{"token": ["CYP3", ",", "the", "gene", "which", "encodes", "the", "C1142644#ent", "<e1>", "the", "isozyme", "responsible", "for", "the", "metabolic", "oxidation", "the", "calcium", "channel-blocking", "drug", "C0028066#ent", "<e2>", ",", "has", "recently", "been", "mapped", "to", "human", "chromosome", "7", "somatic", "cell", "hybrids"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [20, 21]}}
{"token": ["C0037199#ent", "<e1>", "is", "a", "common", "complication", "of", "C0009443#ent", "<e2>", "and", "allergic", "rhinitis", "and", "can", "trigger", "lower", "respiratory", "diseases", "such", "as", "bronchitis", "and", "asthma", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [7, 8]}}
{"token": ["C0017337#ent", "<e1>", "encoding", "novel", "murine", "C0010661#ent", "<e2>", "the", "papain", "family", "C1A", "and", "related", "genes", "were", "cloned", "and", "mapped", "to", "mouse", "chromosome", "13", "colocalizing", "with", "the", "previously", "assigned", "cathepsin", "J", "gene"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010661", "name": "C0010661#ent", "pos": [5, 6]}}
{"token": ["Himalaya", "contains", "700", "bp", "of", "DNA", "that", "is", "homologous", "with", "a", "high", "degree", "of", "nucleotide", "sequence", "to", "exon", "3-intron", "3", "from", "the", "C0017337#ent", "<e1>", "for", "the", "C0010661#ent", "<e2>", "aleurain", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0010661", "name": "C0010661#ent", "pos": [26, 27]}}
{"token": ["In", "vitro", "expression", "of", "a", "construct", "containing", "the", "Lb", "gene", "to", "a", "portion", "of", "the", "VP4", "and", "3D", "C0017337#ent", "<e1>", "demonstrated", "cis", "cleavage", "activity", "could", "be", "blocked", "by", "the", "C0010661#ent", "<e2>", "E-64", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0010661", "name": "C0010661#ent", "pos": [29, 30]}}
{"token": ["Solutions", "containing", "5", "mM", "EDTA/50", "mM", "C0041175#ent", "<e1>", "potentiated", "the", "antimicrobial", "action", "of", "seven", "commercially", "available", "C3668816#ent", "<e2>", "medications", "when", "reacted", "in", "vitro", "Staphylococcus", "aureus", "Streptococcus", "uberis", "and", "Pseudomonas", "aeruginosa"], "h": {"id": "C0041175", "name": "C0041175#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3668816", "name": "C3668816#ent", "pos": [16, 17]}}
{"token": ["Recent", "studies", "in", "this", "laboratory", "revealed", "that", "C1336937#ent", "<e1>", "is", "a", "major", "component", "of", "C0035312#ent", "<e2>", "."], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035312", "name": "C0035312#ent", "pos": [14, 15]}}
{"token": ["In", "vitro", "exogenous", "stimulation", "of", "the", "EGFR-Ras", "signaling", "pathway", "EGF", "or", "transfection", "of", "the", "dominant-active", "form", "of", "the", "C0029016#ent", "<e1>", "H-RasV12", ")", "suppressed", "whereas", "an", "EGFR", "tyrosine", "kinase", "inhibitor", "increased", "C1366566#ent", "<e2>", "mRNA", "and", "protein", "production", "keratinocytes", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1366566", "name": "C1366566#ent", "pos": [30, 31]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "compare", "the", "antihypertensive", "efficacy", "tolerability", "of", "the", "C0006683#ent", "<e1>", "amlodipine", "besylate", "versus", "the", "C2936275#ent", "<e2>", "cilexetil", "in", "hypertensive", "patients", "."], "h": {"id": "C0006683", "name": "C0006683#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2936275", "name": "C2936275#ent", "pos": [20, 21]}}
{"token": ["Deletion", "of", "either", "alpha-homology", "region", "(", "amino", "acids", "-", "55", "or", "226", "-", "267", ")", "from", "the", "C1418740#ent", "<e1>", "sequence", "abolished", "its", "ability", "to", "assemble", "into", "C0035680#ent", "<e2>", "in", "vivo"], "h": {"id": "C1418740", "name": "C1418740#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [26, 27]}}
{"token": ["Stoichiometry", "of", "the", "third", "largest", "subunit", "(", "C1418740#ent", "<e1>", ")", "of", "the", "C0035680#ent", "<e2>", "a", "subject", "of", "continuing", "controversy", "."], "h": {"id": "C1418740", "name": "C1418740#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [12, 13]}}
{"token": ["RNA", "polymerase", "II", "core", "subunit", "3", "C1418740#ent", "<e1>", ")", "is", "an", "a-like", "core", "subunit", "of", "C0035680#ent", "<e2>", "pol", "II", "."], "h": {"id": "C1418740", "name": "C1418740#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [15, 16]}}
{"token": ["Lastly", "enzymes", "known", "as", "C0014559#ent", "<e1>", "which", "are", "important", "in", "C0242209#ent", "<e2>", "and", "deoxysugar", "biosynthesis", "be", "discussed", "with", "reference", "to", "some", "recent", "work", "on", "the", "mechanism", "of", "UDP-glucose", "epimerase"], "h": {"id": "C0014559", "name": "C0014559#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242209", "name": "C0242209#ent", "pos": [10, 11]}}
{"token": ["Additionally", ",", "the", "reversibility", "of", "the", "absorption", "enhancing", "effect", "of", "C1257937#ent", "<e1>", "studied", "by", "applying", "enhancer", "and", "C0030953#ent", "<e2>", "different", "time", "intervals", "calculating", "Area", "the", "Curve", "of", "the", "peptide", "in", "plasma", "."], "h": {"id": "C1257937", "name": "C1257937#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030953", "name": "C0030953#ent", "pos": [17, 18]}}
{"token": ["Hormones", "and", "receptors", "involved", "in", "this", "regulation", "are", ":", "LH", "and", "placental", "analogue", "HCG", ",", "prolactin", "and", "placental", "analogue", "C3538683#ent", "<e1>", ",", "prostaglandins", ",", "oestradiol", "and", "C0002842#ent", "<e2>", "."], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [26, 27]}}
{"token": ["C1823583#ent", "<e1>", "mRNA", "was", "expressed", "in", "various", "tumor", "cells", "but", "not", "in", "adult", "human", "normal", "tissues", "suggesting", "that", "C1823583#ent", "<e1>", "might", "be", "related", "to", "tumor", "C4255166#ent", "<e1>", "."], "h": {"id": "C1823583", "name": "C1823583#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4255166", "name": "C4255166#ent", "pos": [25, 26]}}
{"token": ["The", "catalytic", "domain", "NPP1", "fused", "to", "the", "N-", "and", "C-terminal", "domains", "NPP2", "was", "hyperactive", "as", "a", "C0056696#ent", "<e1>", "but", "did", "not", "show", "any", "C0102190#ent", "<e2>", "."], "h": {"id": "C0056696", "name": "C0056696#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0102190", "name": "C0102190#ent", "pos": [23, 24]}}
{"token": ["All", "had", "C1306889#ent", "<e1>", "ankle", ":", "brachial", "pressure", "index", "than", "0.9", ")", "or", "C0340629#ent", "<e2>"], "h": {"id": "C1306889", "name": "C1306889#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0340629", "name": "C0340629#ent", "pos": [13, 14]}}
{"token": ["Report", "of", "a", "case", "of", "linear", "nevus", "sebaceous", "of", "Jadassohn", "with", "the", "C0431375#ent", "<e1>", "1", ")", "the", "facial", "linear", "nevus", ";", "2", ")", "C0036572#ent", "<e2>", "3", ")", "mental", "retardation"], "h": {"id": "C0431375", "name": "C0431375#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [23, 24]}}
{"token": ["X-ray", "absorption", "spectroscopy", "analysis", "the", "local", "structure", "the", "active", "site", "C1166521#ent", "<e1>", "shows", "marked", "similarity", "to", "that", "of", "the", "C0205723#ent", "<e2>", "Compound", "ES", ",", "which", "contains", "a", "short", "C1166521#ent", "<e1>", "to", "proximal", "nitrogen", "distance", "compared", "to", "globins", "."], "h": {"id": "C0205723", "name": "C0205723#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [10, 11]}}
{"token": ["C0275544#ent", "<e1>", "among", "the", "most", "C3640016#ent", "<e2>", "health", "care", "problems", "."], "h": {"id": "C0275544", "name": "C0275544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3640016", "name": "C3640016#ent", "pos": [5, 6]}}
{"token": ["Mutation", "of", "the", "human", "ortholog", ",", "C2698472#ent", "<e1>", "(", "NIPBL", ")", ",", "causes", "C0270972#ent", "<e2>", "CdLS", ")", ",", "associated", "with", "multiple", "developmental", "defects"], "h": {"id": "C2698472", "name": "C2698472#ent", "pos": [6, 7]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0270972", "name": "C0270972#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "C0251991#ent", "<e1>", "inhibits", "anti-apoptosis", "signaling", "hsp27", "and", "C3541976#ent", "<e2>", "as", "well", "as", "cell", "survival", "signaling", "Akt", "and", "survivin", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541976", "name": "C3541976#ent", "pos": [11, 12]}}
{"token": ["The", "adult", "C0035220#ent", "<e1>", "ARDS", ")", "is", "a", "C0039082#ent", "<e2>", "of", "diffuse", "lung", "injury", "a", "high", "mortality", "rate"], "h": {"id": "C0035220", "name": "C0035220#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}}
{"token": ["C0058594#ent", "<e1>", "like", "other", "primases", ",", "shares", "limited", "homology", "with", "C0035681#ent", "<e2>"], "h": {"id": "C0058594", "name": "C0058594#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [10, 11]}}
{"token": ["These", "two", "genes", ",", "RAS1", "and", "C1336694#ent", "<e1>", ",", "constitute", "an", "essential", "C1335597#ent", "<e2>", "spores", "with", "disruptions", "of", "both", "genes", "fail", "to", "grow", "."], "h": {"id": "C1336694", "name": "C1336694#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335597", "name": "C1335597#ent", "pos": [12, 13]}}
{"token": ["The", "clearance", "of", "theophylline", "and", "C0003420#ent", "<e1>", "(", "antipyrine", ")", "are", "reduced", "by", "C0000598#ent", "<e2>", ",", "resulting", "in", "increased", "plasma", "drug", "."], "h": {"id": "C0003420", "name": "C0003420#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000598", "name": "C0000598#ent", "pos": [13, 14]}}
{"token": ["CT", "scanning", "C0037199#ent", "<e1>", "in", "49", "of", "the", "53", "cases", "(", "C0558362#ent", "<e2>", "42", "cases", ",", "maxillary", "alone", "5", "cases", ",", "sphenoidal", "16", "cases", ")", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0558362", "name": "C0558362#ent", "pos": [11, 12]}}
{"token": ["Allergic", "C0037199#ent", "<e1>", "a", "newly", "recognized", "entity", "consisting", "of", "a", "C0558362#ent", "<e2>", "with", "allergic", "mucinous", "infiltrates", "in", "all", "involved", "sinuses", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0558362", "name": "C0558362#ent", "pos": [10, 11]}}
{"token": ["Allergic", "C0037199#ent", "<e1>", "a", "non-invasive", "disease", "by", "C0558362#ent", "<e2>", "with", "nasal", "polyps", "with", "most", "causative", "agents", "members", "of", "the", "dematiaceous", "fungi"], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0558362", "name": "C0558362#ent", "pos": [7, 8]}}
{"token": ["We", "characterized", "3", "previously", "unidentified", "C1412382#ent", "<e1>", "alternatively", "spliced", "transcripts", "demonstrated", "that", "exon-8-encoded", "C0597298#ent", "<e2>", "processed", "by", "MMP-20", "."], "h": {"id": "C1412382", "name": "C1412382#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [13, 14]}}
{"token": ["3", ")", "C0311284#ent", "<e1>", "is", "the", "disease", "of", "pure", "C0020488#ent", "<e2>"], "h": {"id": "C0311284", "name": "C0311284#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020488", "name": "C0020488#ent", "pos": [9, 10]}}
{"token": ["C2348925#ent", "<e1>", "frequency", "was", "significantly", "increased", "in", "patients", "with", "C0018213#ent", "<e2>", "as", "reported", "previously", "by", "others", ",", "but", "neither", "DNA-derived", "subtype", "of", "DR3", "was", "differentially", "increased", "."], "h": {"id": "C2348925", "name": "C2348925#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018213", "name": "C0018213#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "the", "exon", "33", "SNP", "showed", "evidence", "for", "interaction", "with", "C2348925#ent", "<e1>", "in", "conferring", "susceptibility", "to", "C0018213#ent", "<e2>"], "h": {"id": "C2348925", "name": "C2348925#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018213", "name": "C0018213#ent", "pos": [17, 18]}}
{"token": ["Splenic", "plaque-forming", "cells", "PFC", ")", ",", "hemagglutination", "(", "HA", ")", "titer", "to", "sheep", "red", "blood", "cells", "C1367475#ent", "<e1>", ")", ",", "spleenocytes", "and", "human", "peripheral", "blood", "lymphocytes", "proliferation", "C1705928#ent", "<e2>", ")", "were", "markedly", "suppressed", "by", "MTZ", "treatment", "as", "compared", "to", "control", "group"], "h": {"id": "C1367475", "name": "C1367475#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705928", "name": "C1705928#ent", "pos": [27, 28]}}
{"token": ["Noncovalent", "bonding", "interactions", "of", "nitric", "oxide", "NO", ")", "with", "human", "serum", "albumin", "C0393754#ent", "<e1>", ")", ",", "human", "hemoglobin", "A", "bovine", "myoglobin", "and", "C1537985#ent", "<e2>", "CcO", ")", "have", "been", "explored", "."], "h": {"id": "C0393754", "name": "C0393754#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [22, 23]}}
{"token": ["Administration", "of", "endotoxin", ",", "through", "the", "release", "of", "tumor", "necrosis", "factor-alpha", "C0812246#ent", "<e1>", ")", ",", "provokes", "liver", "inflammation", "hepatocyte", "injury", "the", "C2711227#ent", "<e2>"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [21, 22]}}
{"token": ["We", "explored", "the", "roles", "of", "nuclear", "factor-kappaB", "NF-kappaB", ")", "and", "tumor", "necrosis", "factor", "TNF", ")", "alpha", "(", "C0812246#ent", "<e1>", ")", "as", "mediators", "of", "inflammation", "in", "a", "nutritional", "model", "C2711227#ent", "<e2>", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [28, 29]}}
{"token": ["We", "also", "produced", "cholesterol", "depletion", "C0056170#ent", "<e1>", "treatment", ",", "which", "activates", "SREBP-2", "and", "its", "target", "C0017337#ent", "<e2>", "."], "h": {"id": "C0056170", "name": "C0056170#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["H-NS", "has", "a", "general", "effect", "transcription", "by", "C0056170#ent", "<e1>", "but", "for", "a", "number", "of", "specific", "C0017337#ent", "<e2>", ",", "it", "is", "known", "to", "act", "directly", "as", "repressor", "or", "activator", "."], "h": {"id": "C0056170", "name": "C0056170#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["Reporter", "gene", "cell", "transfection", "experiments", "and", "RNA", "stability", "assays", "that", "hnRNPs", "A1", ",", "C1412756#ent", "<e1>", ",", "and", "K", "stimulate", "C0009325#ent", "<e2>", "expression", "by", "stabilizing", "mRNAs", "."], "h": {"id": "C1412756", "name": "C1412756#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [19, 20]}}
{"token": ["Mutants", "C0907533#ent", "<e1>", "for", "l-fucose", "isomerase", "utilize", "the", "C0022202#ent", "<e2>", "to", "convert", "d-arabinose", "to", "d-ribulose", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022202", "name": "C0022202#ent", "pos": [8, 9]}}
{"token": ["As", "in", "the", "parent", "strain", "the", "C0907533#ent", "<e1>", "formation", "of", "the", "C0022202#ent", "<e2>", "was", "repressed", "by", "D-glucose", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022202", "name": "C0022202#ent", "pos": [11, 12]}}
{"token": ["Both", "mutations", "result", "in", "C0907533#ent", "<e1>", "synthesis", "of", "the", "permease", ",", "the", "C0022202#ent", "<e2>", ",", "and", "the", "kinase", ",", "without", "affecting", "synthesis", "of", "the", "oxidoreductase", "and", "the", "aldolase", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022202", "name": "C0022202#ent", "pos": [12, 13]}}
{"token": ["Also", ",", "C1704838#ent", "<e1>", "and", "Mcs2", "can", "associate", "with", "the", "heterologous", "partners", "human", "C0258442#ent", "<e2>", "MO15", ",", "respectively", "."], "h": {"id": "C1704838", "name": "C1704838#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0258442", "name": "C0258442#ent", "pos": [13, 14]}}
{"token": ["C1099414#ent", "<e1>", "1", "%", "cream", "is", "approved", "for", "C0011615#ent", "<e2>", "and", "also", "has", "a", "great", "potential", "in", "other", "inflammatory", "skin", "diseases"], "h": {"id": "C1099414", "name": "C1099414#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [8, 9]}}
{"token": ["Both", "furafylline", ",", "a", "C1620185#ent", "<e1>", "inhibitor", ",", "and", "N-nitrosodimethylamine", ",", "a", "C3887686#ent", "<e2>", "substrate", ",", "inhibited", "the", "formation", "of", "keto", "alcohol", "not", "keto", "aldehyde", "human", "liver", "microsomes", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [12, 13]}}
{"token": ["Analysis", "of", "Chinese", "hamster", "ovary", "cells", "expression", "of", "C1417617#ent", "<e1>", "and", "NDST2", ",", "but", "not", "C1417619#ent", "<e2>", "."], "h": {"id": "C1417617", "name": "C1417617#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417619", "name": "C1417619#ent", "pos": [15, 16]}}
{"token": ["Incubating", "muscles", "with", "concentrations", "of", "rapamycin", "that", "inhibited", "activation", "of", "C1136240#ent", "<e1>", "the", "activation", "of", "C1415377#ent", "<e2>"], "h": {"id": "C1136240", "name": "C1136240#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415377", "name": "C1415377#ent", "pos": [15, 16]}}
{"token": ["Several", "studies", "have", "suggested", "a", "dose-response", "relation", "the", "oestrogen", "content", "of", "oral", "contraceptive", "C3539565#ent", "<e1>", ")", "and", "the", "risk", "of", "both", "venous", "thrombosis", "C0852949#ent", "<e2>", "when", "oestrogen", "doses", "higher", "than", "50", "micrograms", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0852949", "name": "C0852949#ent", "pos": [23, 24]}}
{"token": ["We", "investigated", "the", "inhibitory", "effects", "of", "neopterin", "(", "C1706141#ent", "<e1>", ")", "and", "its", "reduced", "form", ",", "C0163411#ent", "<e2>", "(", "NPH4", ")", ",", "on", "carbon", "tetrachloride", "hepatotoxicity", "."], "h": {"id": "C1706141", "name": "C1706141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0163411", "name": "C0163411#ent", "pos": [16, 17]}}
{"token": ["We", "evaluated", "the", "use", "of", "10H3", ",", "a", "monoclonal", "antibody", "C2828027#ent", "<e1>", "targeting", "A", "C1414078#ent", "<e2>", "28", "labeled", "with", "Tc-99m"], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414078", "name": "C1414078#ent", "pos": [14, 15]}}
{"token": ["The", "C1417932#ent", "<e1>", "a", "single", "polypeptide", "Mr", "=", "68,000", ")", "and", "requires", "a", "C0599532#ent", "<e2>", "and", "pyridoxal", "phosphate", "activity", "."], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [13, 14]}}
{"token": ["Unexpectedly", ",", "however", ",", "the", "monkey", "ovary", "also", "found", "to", "contain", "a", "network", "of", "C1363982#ent", "<e1>", "immunoreactive", "cells", "distributed", "throughout", "the", "ovarian", "medulla", "C0001614#ent", "<e2>", "."], "h": {"id": "C1363982", "name": "C1363982#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [23, 24]}}
{"token": ["As", "evidence", ",", "FC", "loading", "by", "non-SRA", "mechanisms", "p38", "and", "C1413947#ent", "<e1>", ",", "but", "not", "apoptosis", "unless", "the", "C1420394#ent", "<e2>", "is", "engaged", "."], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420394", "name": "C1420394#ent", "pos": [18, 19]}}
{"token": ["The", "downstream", "apoptosis", "effectors", "include", "CHOP", "(", "C1413947#ent", "<e1>", ")", "for", "the", "UPR", "and", "JNK", "for", "C1420394#ent", "<e2>", "signalling", "."], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420394", "name": "C1420394#ent", "pos": [16, 17]}}
{"token": ["The", "transport", "of", "proline", ",", "in", "contrast", "to", "that", "of", "other", "C3539947#ent", "<e1>", "was", "found", "to", "be", "insensitive", "to", "various", "respiratory", "inhibitors", "e.g.", "C0056650#ent", "<e2>", ",", "arsenate", ",", "azide", ",", "and", "sulfhydryl", "reagents"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0056650", "name": "C0056650#ent", "pos": [23, 24]}}
{"token": ["The", "technique", "has", "proved", "useful", "in", "studying", "C0019069#ent", "<e1>", ",", "tumors", "of", "the", "extremities", ",", "C0029408#ent", "<e2>", "and", "vascular", "conditions", "including", "the", "complications", "of", "diabetes", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [15, 16]}}
{"token": ["The", "majority", "of", "severe", "C0019069#ent", "<e1>", "will", "develop", "a", "crippling", "C0029408#ent", "<e2>", "consequent", "upon", "recurrent", "haemarthroses", "although", "the", "pathogenic", "mechanism", "remains", "unclear", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [10, 11]}}
{"token": ["The", "specific", "activity", "of", "the", "purified", "C0041931#ent", "<e1>", "was", "19.8", "U/mg", "using", "either", "\"", "urate", "\"", "C0001275#ent", "<e2>", "."], "h": {"id": "C0041931", "name": "C0041931#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001275", "name": "C0001275#ent", "pos": [16, 17]}}
{"token": ["C0567085#ent", "<e1>", "venous", "plasma", "levels", "in", "C0002335#ent", "<e2>", "increased", "markedly", "after", "Day", "11", "of", "pregnancy", "and", "reached", "very", "high", "concentrations", "in", "some", "rabbits", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002335", "name": "C0002335#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", "the", "ING1", "and", "ING2", "genes", "have", "different", "roles", "in", "lung", "carcinogenesis", "progression", ",", "and", "the", "C1416437#ent", "<e1>", "be", "an", "independent", "tumor", "suppressor", "on", "C1705526#ent", "<e2>", "."], "h": {"id": "C1416437", "name": "C1416437#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [27, 28]}}
{"token": ["Bedtime", "inhalation", "of", "a", "novel", "muscarinic", "M3", "receptor", "antagonist", "lowered", "ambulatory", "blood", "pressure", "ABP", ")", ",", "predominantly", "during", "sleep", ",", "in", "a", "chronic", "obstructive", "pulmonary", "disease", "C1647218#ent", "<e1>", ")", "patient", "with", "masked", "C0020538#ent", "<e2>"], "h": {"id": "C1647218", "name": "C1647218#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [32, 33]}}
{"token": ["Vitreous", "enters", "the", "subretinal", "space", "C0271055#ent", "<e1>", "but", "the", "protein", "concentration", "subretinal", "fluid", "C0035305#ent", "<e2>", "much", "higher", "than", "in", "vitreous", "."], "h": {"id": "C0271055", "name": "C0271055#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0035305", "name": "C0035305#ent", "pos": [13, 14]}}
{"token": ["Our", "finding", "that", "sodium", "butyrate", "Trichostatin", "A", "inhibit", "both", "SRC", "promoters", "suggest", "this", "C1417123#ent", "<e1>", "may", "be", "a", "major", "target", "of", "these", "C0035064#ent", "<e2>", ",", "and", "may", "explain", "in", "part", "their", "anti-cancer", "activity", "."], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [22, 23]}}
{"token": ["These", "results", "provide", "a", "basis", "for", "DHBV", "integrations", "to", "function", "as", "activators", "of", "C1417123#ent", "<e1>", ",", "as", "well", "as", "C0035064#ent", "<e2>", "of", "the", "loss", "of", "tumor", "suppressor", "genes", "hepatocellular", "carcinogenesis"], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [19, 20]}}
{"token": ["Titers", "of", "IgG-RF", "were", "higher", "in", "the", "active", "phase", "in", "the", "inactive", "phase", "of", "C0014060#ent", "<e1>", "and", "showed", "a", "correlation", "to", "the", "levels", "of", "C0853888#ent", "<e2>", "and", "circulating", "immune", "complexes", "C0014060#ent", "<e1>", "sera", "."], "h": {"id": "C0853888", "name": "C0853888#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "high", "titers", "FANAs", "and", "anti-single", "stranded", "anti-double", "stranded", "DNA", "antibodies", "positive", "anti-ribonucleoprotein", "or", "Sm", "antibodies", "leukocytopenia", ",", "and", "C0853888#ent", "<e1>", "were", "characteristic", "for", "C0014060#ent", "<e2>", "."], "h": {"id": "C0853888", "name": "C0853888#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [26, 27]}}
{"token": ["Capture", "ELISAs", "with", "biotinylated", "monospecific", "antibodies", "were", "developed", "to", "detect", "both", "C-reactive", "protein", "CRP", ")", "and", "haptoglobin", "(", "C1704665#ent", "<e1>", ")", "in", "serum", "of", "adult", "C0001342#ent", "<e2>", "(", "AP", ")", "patients", "and", "normal", "subjects"], "h": {"id": "C1704665", "name": "C1704665#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0001342", "name": "C0001342#ent", "pos": [25, 26]}}
{"token": ["The", "21-kDa", "Vaccinia", "virus", "VH1-related", "C1869199#ent", "<e1>", ")", "dual-specific", "protein", "phosphatase", "encoded", "by", "the", "C1333258#ent", "<e2>", "plays", "a", "critical", "role", "in", "cell", "cycle", "progression", "and", "is", "itself", "regulated", "during", "the", "cell", "cycle"], "h": {"id": "C1869199", "name": "C1869199#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333258", "name": "C1333258#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "work", "was", "to", "identify", "structural/functional", "sites", "on", "C1366645#ent", "<e1>", "interacting", "with", "C0009325#ent", "<e2>", "."], "h": {"id": "C1366645", "name": "C1366645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}}
{"token": ["This", "activity", "was", "inhibited", "by", "the", "C1418253#ent", "<e1>", "amiloride", "but", "not", "by", "antibodies", "against", "C0032143#ent", "<e2>"], "h": {"id": "C1418253", "name": "C1418253#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [14, 15]}}
{"token": ["Supercritical", "fluid", "extraction", "also", "applied", "in", "order", "to", "improve", "the", "extraction", "efficiency", "of", "Cephalotaxus", "alkaloids", "as", "C0018606#ent", "<e1>", ",", "harringtonine", ",", "homoharringtonine", ",", "and", "C0063979#ent", "<e2>", "."], "h": {"id": "C0018606", "name": "C0018606#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0063979", "name": "C0063979#ent", "pos": [24, 25]}}
{"token": ["Harringtonine", "(", "HT", ")", ",", "C0018606#ent", "<e1>", "(", "HHT", ")", "and", "C0063979#ent", "<e2>", "(", "IHT", ")", "are", "cephalotaxine", "alkaloids", "anticancer", "activities", "were", "isolated", "from", "Cephalotaxus", "hainanensis", "indigenous", "to", "China", "."], "h": {"id": "C0018606", "name": "C0018606#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0063979", "name": "C0063979#ent", "pos": [11, 12]}}
{"token": ["CMT", "blocked", "C0006949#ent", "<e1>", "induction", "of", "C1862824#ent", "<e2>", "the", "rise", "in", "urinary", "6", "beta-hydroxycortisol", "excretion", "was", "unaffected", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1862824", "name": "C1862824#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "C0039286#ent", "<e1>", "treatment", "resulted", "in", "an", "increased", "level", "of", "hypophosphorylated", "active", "C1705628#ent", "<e2>", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [13, 14]}}
{"token": ["C0075616#ent", "<e1>", ",", "a", "new", "anti-inflammatory", "agent", "and", "its", "C0038761#ent", "<e2>", "and", "sulfide", "metabolites", "were", "conjugated", "to", "bovine", "serum", "albumin", "by", "the", "N-hydroxysuccinimide", "active", "ester", "procedure", "."], "h": {"id": "C0075616", "name": "C0075616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038761", "name": "C0038761#ent", "pos": [9, 10]}}
{"token": ["The", "extracellular", "portion", "amino", "acids", "1", "844", ")", "of", "the", "C0672504#ent", "<e1>", "EHV-1", ")", "glycoprotein", "gp14", ",", "the", "C1334043#ent", "<e2>", "of", "gB", "of", "herpes", "simplex", "virus", "was", "expressed", "in", "Escherichia", "coli", "in", "insect", "cells", "a", "recombinant", "baculovirus"], "h": {"id": "C0672504", "name": "C0672504#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["The", "envelope", "glycoprotein", "2", "gp2", ")", "of", "equine", "herpesvirus", "1", "C0672504#ent", "<e1>", ")", "has", "no", "known", "C1334043#ent", "<e2>", "in", "other", "herpesviruses", "with", "the", "exception", "of", "some", "equid", "alphaherpesviruses"], "h": {"id": "C0672504", "name": "C0672504#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}}
{"token": ["The", "zinc", "finger", "in", "the", "C-terminal", "of", "the", "proteins", "from", "HSV-1", ",", "VZV", "and", "C0672504#ent", "<e1>", ",", "is", "poorly", "conserved", "in", "C1334043#ent", "<e2>"], "h": {"id": "C0672504", "name": "C0672504#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [21, 22]}}
{"token": ["C1826968#ent", "<e1>", "p25A", "shares", "about", "28", "and", "44", "%", "C2917660#ent", "<e2>", "homology", "with", "the", "ras", "and", "ypt1", "proteins", ",", "respectively", "."], "h": {"id": "C1826968", "name": "C1826968#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [9, 10]}}
{"token": ["In", "vivo", "effects", "of", "C0919490#ent", "<e1>", "were", "reflected", "in", "activation", "of", "BAD", ",", "cleavage", "of", "C0534519#ent", "<e2>", ",", "apoptotic", "DNA", "fragmentation", "inhibition", "of", "VEGF", "production", "observed", "in", "in", "vitro", "TT", "cells", "."], "h": {"id": "C0919490", "name": "C0919490#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [15, 16]}}
{"token": ["Treatment", "with", "propranolol", ",", "C0036442#ent", "<e1>", ",", "or", "flurazepam", "(", "C0733803#ent", "<e2>", ")", "conferred", "a", "relative", "risk", "delirium", "of", "11.7", "(", "p", "=", "0.0028", ")", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0733803", "name": "C0733803#ent", "pos": [10, 11]}}
{"token": ["However", ",", "modified", "forms", "of", "C2363128#ent", "<e1>", ")", ",", "which", "are", "C0907533#ent", "<e2>", "nuclear", ",", "could", "also", "lead", "to", "the", "phosphorylation", "of", "Stat3", "."], "h": {"id": "C2363128", "name": "C2363128#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [11, 12]}}
{"token": ["Interestingly", ",", "whole-cell", "pertussis", "vaccine-induced", "anti-hsp", "antibodies", "cross-reacted", "with", "the", "Escherichia", "coli", "GroEL", "C3890018#ent", "<e1>", ",", "and", "at", "a", "some", "extent", "with", "the", "human", "60-kDa", "C3890018#ent", "<e1>", ",", "belonging", "to", "the", "same", "C0034152#ent", "<e1>"], "h": {"id": "C3890018", "name": "C3890018#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [32, 33]}}
{"token": ["There", "may", "be", "a", "role", "for", "IV", "IgG", "C0038317#ent", "<e1>", ",", "especially", "for", "cases", "of", "C1839163#ent", "<e2>", "that", "are", "immune-mediated", ";", "however", ",", "further", "investigations", "are", "necessary", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [15, 16]}}
{"token": ["When", "the", "patient", "was", "treated", "with", "C0038317#ent", "<e1>", "and", "chemotherapy", ",", "the", "C1839163#ent", "<e2>", "resolved", "and", "platelet-associated", "IgG", "disappeared", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [12, 13]}}
{"token": ["Adult", "acid", "maltase", "deficiency", "C1412379#ent", "<e1>", ",", "glycogen", "storage", "disease", "type", "II", "may", "involve", "respiratory", "muscles", "to", "severe", "C1145670#ent", "<e2>", "before", "the", "affection", "of", "pelvic", "girdle", "muscles", "turned", "the", "patient", "non-ambulatory", "."], "h": {"id": "C1412379", "name": "C1412379#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [18, 19]}}
{"token": ["Neither", "the", "Km", "of", "[3H]DA", "uptake", "(", "approximately", "200", "nM", ")", "nor", "the", "affinity", "of", "various", "substrates", "and", "C0597607#ent", "<e1>", "altered", "by", "either", "PMA", "or", "C0075193#ent", "<e2>", "treatment", "."], "h": {"id": "C0597607", "name": "C0597607#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [25, 26]}}
{"token": ["Unlike", "a", "C0669365#ent", "<e1>", "active", "ErbB2", "mutant", ",", "the", "C0812267#ent", "<e2>", "mutants", "are", "not", "coupled", "to", "increased", "cell", "proliferation", "loss", "of", "contact", "inhibition", ",", "or", "anchorage", "independence", "in", "a", "rodent", "fibroblast", "cell", "line"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812267", "name": "C0812267#ent", "pos": [9, 10]}}
{"token": ["Delayed", "cytotoxicity", "was", "demonstrated", "for", "TG-Pt(II", ")", "as", "well", "as", "for", "C0039902#ent", "<e1>", "and", "other", "C0280038#ent", "<e2>", "not", "for", "SeG-Pt(II", ")", "or", "cis-dichlorodiammineplatinum(II", ")", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0280038", "name": "C0280038#ent", "pos": [15, 16]}}
{"token": ["On", "day", "12", ",", "among", "the", "streptozotocin-injected", "animals", "only", "those", "treated", "with", "C0017082#ent", "<e1>", "normoglycaemic", ",", "whereas", "on", "day", "24", "all", "streptozotocin", "mice", "C1263960#ent", "<e2>", "."], "h": {"id": "C0017082", "name": "C0017082#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1263960", "name": "C1263960#ent", "pos": [23, 24]}}
{"token": ["The", "conclusion", "is", "that", "C0014479#ent", "<e1>", "is", "suitable", "for", "the", "mild", "form", "of", "C0004096#ent", "<e2>"], "h": {"id": "C0014479", "name": "C0014479#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "an", "unusual", "family", "with", "a", "fatal", "C0567439#ent", "<e1>", "neonatal", "diabetes", "mellitus", "DM", ")", ",", "enteropathy", ",", "C0014130#ent", "<e2>", ",", "and", "severe", "infections", "with", "variable", "thrombocytopenia"], "h": {"id": "C0567439", "name": "C0567439#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [18, 19]}}
{"token": ["C0069805#ent", "<e1>", "Oxy", ")", "has", "been", "used", "successfully", "in", "C0005697#ent", "<e2>", "patients", "who", "remained", "wet", "on", "oral", "anticholinergics", "could", "not", "tolerate", "oral", "medication"], "h": {"id": "C0069805", "name": "C0069805#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [9, 10]}}
{"token": ["Sequencing", "of", "the", "C0008533#ent", "<e1>", "the", "presence", "of", "an", "open", "reading", "frame", "C0079941#ent", "<e2>", ")", "of", "1051", "nucleotides", ",", "which", "should", "correspond", "to", "the", "HemB", "protein", "."], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [12, 13]}}
{"token": ["Anti-thymocyte", "mIg", "sera", "absorbed", "with", "C1706005#ent", "<e1>", "lose", "their", "capacity", "to", "bind", "thymocyte", "C1707170#ent", "<e2>", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1707170", "name": "C1707170#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "utilize", "in", "vitro", "whole-cell", "immunofluorescence", "microscopy", "assays", "to", "demonstrate", "that", "ntcp", "is", "present", "on", "intracellular", "vesicles", "bind", "C0796074#ent", "<e1>", "and", "move", "bidirectionally", ",", "using", "C0085139#ent", "<e2>", "and", "dynein", "."], "h": {"id": "C0796074", "name": "C0796074#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0085139", "name": "C0085139#ent", "pos": [27, 28]}}
{"token": ["C-terminal", "half", "the", "protein", "retains", "a", "region", "conserved", "between", "C0812329#ent", "<e1>", "src", "family", ",", "phospholipase", "C(PLC)-148", "and", "the", "C0812252#ent", "<e2>"], "h": {"id": "C0812329", "name": "C0812329#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [18, 19]}}
{"token": ["C4283800#ent", "<e1>", "and", "-32", "were", "reduced", "in", "LPS-HC", ",", "C3539565#ent", "<e2>", ",", "and", "CCF", "."], "h": {"id": "C4283800", "name": "C4283800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539565", "name": "C3539565#ent", "pos": [9, 10]}}
{"token": ["These", "data", "indicate", "that", "long-term", "treatment", "with", "C0051696#ent", "<e1>", ",", "in", "patients", "with", "severe", "C1956346#ent", "<e2>", "reduced", "the", "number", "of", "angina", "attacks", "nitroglycerin", "consumption", "and", "produced", "a", "sustained", "improvement", "in", "exercise", "performance", "."], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "the", "immediate", "impact", "of", "C0051696#ent", "<e1>", "in", "stable", "C1956346#ent", "<e2>", "to", "reduce", "left", "ventricular", "afterload", "and", "thereby", "improve", "cardiac", "pumping", "performance", "."], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [10, 11]}}
{"token": ["At", "the", "time", "of", "operation", "the", "mean", "duration", "of", "C0018801#ent", "<e1>", "3", "weeks", "and", "duration", "of", "C0014118#ent", "<e2>", "9", "weeks", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [16, 17]}}
{"token": ["We", "report", "a", "74-year-old", "woman", "with", "C0018801#ent", "<e1>", "recurrent", "ischemic", "strokes", "the", "presenting", "features", "of", "a", "nonbacterial", "C0014118#ent", "<e2>", "complicating", "a", "gastric", "adenocarcinoma"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [17, 18]}}
{"token": ["To", "measure", "synovial", "fluid", "C1442521#ent", "<e1>", ")", "levels", "of", "C1704264#ent", "<e2>", "IL-1ra", ")", "and", "to", "determine", "the", "capacity", "of", "C1442521#ent", "<e1>", "neutrophils", "(", "PMN", ")", "to", "synthesize", "and", "release", "IL-1ra", "."], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704264", "name": "C1704264#ent", "pos": [9, 10]}}
{"token": ["We", "found", "that", "C1705316#ent", "<e1>", "consists", "of", "two", "physically", "separable", "functional", "domains", "a", "polymerase", "domain", "RNA", "interaction", "domain", "2", "C1334077#ent", "<e2>", ")", ",", "reverse", "transcriptase", "RT", ")", ",", "and", "C-terminal", "sequences", "and", "a", "major", "accessory", "domain", "RNA", "interaction", "domain", "1", "RID1", ")", "."], "h": {"id": "C1705316", "name": "C1705316#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334077", "name": "C1334077#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "suggest", "that", "functional", "C1705316#ent", "<e1>", "complementation", "requires", "intact", "C1334077#ent", "<e2>", "and", "RT", "domains", "on", "the", "same", "hTERT", "molecule", "is", "dependent", "on", "hTR", "and", "the", "N", "terminus", "."], "h": {"id": "C1705316", "name": "C1705316#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334077", "name": "C1334077#ent", "pos": [10, 11]}}
{"token": ["Results", "of", "haemosorption", "with", "the", "use", "of", "activated", "C0524928#ent", "<e1>", "IGI", "in", "patients", "with", "different", "C0012634#ent", "<e2>", "of", "the", "liver", "are", "given", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["VfGlu1", "mutants", "displayed", "reduced", "virulence", "and", "diminished", "ability", "to", "utilize", "chitin", "as", "a", "C0524928#ent", "<e1>", "source", ",", "implicating", "VfGlu1", "in", "the", "C0012634#ent", "<e2>"], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [21, 22]}}
{"token": ["Activation", "of", "MEK", ",", "the", "physiological", "activator", "C1370600#ent", "<e1>", ",", "by", "anti-CD3", "or", "PMA", "is", "not", "affected", "by", "C1571063#ent", "<e2>", "deletion", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1571063", "name": "C1571063#ent", "pos": [18, 19]}}
{"token": ["In", "order", "to", "gain", "further", "insight", "into", "the", "interaction", "of", "C1571063#ent", "<e1>", "with", "C1370600#ent", "<e2>", ",", "we", "determined", "the", "structure", "of", "the", "PTP", "catalytic", "domain", "C1571063#ent", "<e1>", ",", "residues", "44", "-", "339", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1571063", "name": "C1571063#ent", "pos": [10, 11]}}
{"token": ["A", "related", "syndrome", ",", "the", "C1858391#ent", "<e1>", "is", "due", "to", "mutations", "of", "the", "C3273855#ent", "<e2>"], "h": {"id": "C1858391", "name": "C1858391#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273855", "name": "C3273855#ent", "pos": [13, 14]}}
{"token": ["A", "29-year-old", "patient", "presented", "with", "recurrent", "C0041834#ent", "<e1>", "both", "lower", "legs", "of", "15", "years", "'", "C0720099#ent", "<e2>", "."], "h": {"id": "C0041834", "name": "C0041834#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [15, 16]}}
{"token": ["MN", "was", "chosen", "as", "the", "model", "compound", "since", "it", "was", "capable", "of", "causing", "C0041834#ent", "<e1>", "the", "intensity", "and", "C0720099#ent", "<e2>", "of", "which", "was", "proportional", "to", "the", "amount", "entering", "the", "living", "epidermis", "time", "."], "h": {"id": "C0041834", "name": "C0041834#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [18, 19]}}
{"token": ["A", "4-hr", "occluded", "cutaneous", "application", "with", "0.5", "ml", "PP", "in", "rabbits", "produced", "mild", "to", "moderate", "C0041834#ent", "<e1>", "and", "edema", "of", "about", "3", "days", "C0720099#ent", "<e2>", ",", "but", "no", "signs", "of", "corrosion", "."], "h": {"id": "C0041834", "name": "C0041834#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [23, 24]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "rat", "C1414544#ent", "<e2>", "was", "isolated", "from", "a", "rat", "genomic", "Charon", "4A", "library", "by", "screening", "with", "a", "cDNA", "to", "the", "rat", "liver", "enzyme"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414544", "name": "C1414544#ent", "pos": [5, 6]}}
{"token": ["By", "deletion", "analysis", "the", "fusion", "genes", "and", "PCK1-lacZ", "we", "have", "identified", "a", "number", "of", "strong", "regulatory", "regions", "the", "C0017337#ent", "<e1>", "FBP1", "and", "PCK1", "which", "encode", "C1414544#ent", "<e2>", "and", "phosphoenolpyruvate", "carboxykinase"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414544", "name": "C1414544#ent", "pos": [25, 26]}}
{"token": ["We", "performed", "a", "dose-finding", "study", "in", "human", "HD", "of", "C1882164#ent", "<e1>", "SPB", ")", ",", "a", "C0019643#ent", "<e2>", "inhibitor", "that", "ameliorates", "the", "HD", "phenotype", "in", "animal", "models"], "h": {"id": "C1882164", "name": "C1882164#ent", "pos": [9, 10]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [15, 16]}}
{"token": ["Studies", "of", "a", "patient", "with", "C1332655#ent", "<e1>", "that", "there", "was", "no", "binding", "of", "anti-human", "C1332656#ent", "<e2>", "or", "anti-human", "C3", "g", "to", "this", "subject's", "epidermal", "basement", "membrane"], "h": {"id": "C1332655", "name": "C1332655#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332656", "name": "C1332656#ent", "pos": [14, 15]}}
{"token": ["The", "eight", "C0360390#ent", "<e1>", "tested", "were", "rifampicin", ",", "isoniazid", ",", "C0014964#ent", "<e2>", ",", "streptomycin", ",", "kanamycin", ",", "levofloxacin", ",", "sparfloxacin", "and", "ciprofloxacin", "."], "h": {"id": "C0360390", "name": "C0360390#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0014964", "name": "C0014964#ent", "pos": [10, 11]}}
{"token": ["C0001927#ent", "<e1>", "did", "not", "affect", "the", "histamine-induced", "plasma", "extravasation", "whereas", "C0060657#ent", "<e2>", "reduced", "the", "plasma", "extravasation", "the", "main", "bronchi", ",", "but", "not", "in", "the", "trachea", ",", "of", "the", "animals", "exposed", "to", "ozone", "."], "h": {"id": "C0001927", "name": "C0001927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0060657", "name": "C0060657#ent", "pos": [10, 11]}}
{"token": ["C0001927#ent", "<e1>", ",", "terbutaline", ",", "salmeterol", "and", "C0060657#ent", "<e2>", "are", "legally", "admitted", "when", "administrated", "by", "MDI", "in", "the", "treatment", "of", "asthma", "."], "h": {"id": "C0001927", "name": "C0001927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0060657", "name": "C0060657#ent", "pos": [7, 8]}}
{"token": ["Naproxen", "and", "C0020740#ent", "<e1>", ",", "two", "highly", "used", "non-steroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e2>", ")", ",", "and", "caffeine", ",", "were", "the", "predominant", "compounds", "."], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [11, 12]}}
{"token": ["C0020740#ent", "<e1>", "and", "other", "C0003211#ent", "<e2>", "NSAIDs", ")", "are", "proven", "treatments", "for", "such", "IUD-induced", "problems", ",", "but", "their", "effect", "on", "early", "IUD", "removal", "is", "unknown", "."], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [4, 5]}}
{"token": ["POEMS", "syndrome", "is", "characterized", "by", "simultaneous", "appearance", "of", "C0152025#ent", "<e1>", ",", "the", "enlargement", "of", "internal", "organs", "C0339143#ent", "<e2>", ",", "monoclonal", "gammapathy", "skin", "changes"], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [16, 17]}}
{"token": ["These", "include", "HIV", "infection", "autoimmune-disease-associated", "lymphadenopathy", ",", "idiopathic", "plasmacytic", "lymphadenopathy", "polyclonal", "hyperimmunoglobulinemia", "\"", "idiopathic", "MCD", ",", "POEMS", "syndrome", "(", "C0152025#ent", "<e1>", ",", "anasarca", ",", "organomegaly", ",", "C0339143#ent", "<e2>", ",", "M-proteins", ",", "and", "skin", "lesions", ",", "and", "non-Hodgkin's", "lymphomas"], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [26, 27]}}
{"token": ["POEMS", "syndrome", "is", "a", "systemic", "disease", "characterized", "by", "severe", "C0152025#ent", "<e1>", "organomegaly", "(", "adenopathy", ",", "and", "liver", "enlargement", "C0339143#ent", "<e2>", ",", "monoclonal", "peak", ",", "sclerotic", "bone", "lesions", "skin", "changes"], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "the", "atorvastatin-induced", "phosphorylation", "of", "C1120843#ent", "<e1>", "attenuated", "by", "SB203580", ",", "whereas", "it", "was", "enhanced", "by", "C0298346#ent", "<e2>", "."], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0298346", "name": "C0298346#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "siRNA-mediated", "knockdown", "of", "C1540191#ent", "<e1>", "in", "3T3-L1", "adipocytes", "had", "no", "effect", "glycerol", "or", "C1417875#ent", "<e2>", "release", "."], "h": {"id": "C1540191", "name": "C1540191#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417875", "name": "C1417875#ent", "pos": [16, 17]}}
{"token": ["The", "C3494348#ent", "<e1>", "inhibitory", "activity", "all", "the", "animal", "collagenases", "tested", ",", "except", "for", "C0172956#ent", "<e2>"], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0172956", "name": "C0172956#ent", "pos": [13, 14]}}
{"token": ["However", ",", "OAG", "application", "or", "elevated", "endogenous", "DAG", ",", "resulting", "from", "either", "DAG", "lipase", "C3888278#ent", "<e1>", "inhibition", ",", "completely", "prevented", "C1704886#ent", "<e2>", "or", "TRPC4", "activation", "."], "h": {"id": "C3888278", "name": "C3888278#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1704886", "name": "C1704886#ent", "pos": [20, 21]}}
{"token": ["MCM4", "and", "C1334493#ent", "<e1>", "are", "also", "phosphorylated", "by", "C0108836#ent", "<e2>", "albeit", "to", "less", "extent", "."], "h": {"id": "C1334493", "name": "C1334493#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0108836", "name": "C0108836#ent", "pos": [8, 9]}}
{"token": ["The", "most", "widely", "used", "nitrosoureas", ",", "lomustine", "and", "C0007257#ent", "<e1>", ",", "are", "known", "to", "be", "hepatotoxic", "and", "to", "induce", "C0008311#ent", "<e2>", "and", "intrahepatic", "cholestasis", "which", "in", "the", "long", "term", "to", "cholangiolysis", "and", "biliary", "cirrhosis"], "h": {"id": "C0007257", "name": "C0007257#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [19, 20]}}
{"token": ["A", "total", "of", "75", "human", "subjects", "were", "studied", ":", "6", "controls", "without", "liver", "diseases", "51", "patients", "with", "C0008679#ent", "<e1>", "18", "patients", "with", "C0001314#ent", "<e2>"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001314", "name": "C0001314#ent", "pos": [22, 23]}}
{"token": ["The", "subjects", "had", "abdominal", "tuberculosis", "group", "1", ",", "C0017178#ent", "<e1>", "than", "tuberculosis", "(", "group", "2", ",", "C0023890#ent", "<e2>", "of", "the", "liver", "(", "group", "3", ",", "and", "peritoneal", "malignancy", "group", "4", "."], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [16, 17]}}
{"token": ["For", "benign", "C0017178#ent", "<e1>", "the", "rates", "were", ":", "C0023890#ent", "<e2>", "%", ",", "chronic", "hepatitis", "%", ",", "acute", "hepatitis", "%", ",", "other", "liver", "diseases", "%", ",", "cholelithiasis", "30.0", "%", ",", "and", "chronic", "pancreatitis", "%", "."], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [8, 9]}}
{"token": ["Similar", "dose-dependent", "generalization", "with", "C0008188#ent", "<e1>", ",", "pentobarbital", ",", "and", "C0025659#ent", "<e2>", "was", "also", "noted", "in", "both", "the", "aged", "and", "adult", "animals", "."], "h": {"id": "C0008188", "name": "C0008188#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025659", "name": "C0025659#ent", "pos": [10, 11]}}
{"token": ["This", "enhancement", "in", "lipid", "mediator", "generation", "correlated", "with", "a", "time-dependent", "synergism", "in", "C0086376#ent", "<e1>", "after", "sequential", "stimulation", "of", "intact", "cells", "with", "C1705725#ent", "<e2>", "and", "NaF", "or", "thrombin", "and", "NaF", ",", "respectively", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [21, 22]}}
{"token": ["Our", "data", "suggest", "that", "C1705725#ent", "<e1>", ",", "C5a", "and", "LTB4", "effectively", "activate", "the", "C0086376#ent", "<e2>", ",", "Gi2", "and", "Gi3", ",", "in", "HL-60", "cells", "that", "C1705725#ent", "<e1>", "may", "additionally", "activate", "PTX-insensitive", "G-proteins", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [4, 5]}}
{"token": ["We", "determined", "the", "crystal", "structure", "Thermus", "aquaticus", "core", "C0035678#ent", "<e1>", "complexed", "with", "C1423669#ent", "<e2>", "."], "h": {"id": "C0035678", "name": "C0035678#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1423669", "name": "C1423669#ent", "pos": [12, 13]}}
{"token": ["We", "show", "that", "the", "C3811244#ent", "<e1>", "is", "able", "to", "unveil", "the", "C1708423#ent", "<e2>", "evoked", "by", "the", "critical", "stimuli", "as", "a", "weakly", "dominant", "mode", "from", "the", "covering", "sentence", "final", "negativity", "."], "h": {"id": "C3811244", "name": "C3811244#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1708423", "name": "C1708423#ent", "pos": [11, 12]}}
{"token": ["So", "far", "no", "assay", "procedure", "been", "reported", "for", "the", "estimation", "of", "this", "C1254351#ent", "<e1>", "either", "in", "C3273153#ent", "<e2>", "pharmaceutical", "formulations", "in", "biological", "samples"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273153", "name": "C3273153#ent", "pos": [16, 17]}}
{"token": ["In", "order", "to", "assess", "the", "pharmaceutical", "quality", "of", "the", "C1254351#ent", "<e1>", "we", "evaluated", "the", "content", "of", "these", "bioactive", "compounds", "40", "commercial", "C3273153#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273153", "name": "C3273153#ent", "pos": [21, 22]}}
{"token": ["Recovery", "from", "neurological", "sequelae", "C1096184#ent", "<e1>", "infection", "including", "cognitive", "deficits", "C3714552#ent", "<e2>", "may", "be", "prolonged", "and", "incomplete", "."], "h": {"id": "C1096184", "name": "C1096184#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [10, 11]}}
{"token": ["Cohort", "studies", "humans", "suggest", "that", "CRT", "has", "a", "differential", "effect", "the", "arrhythmogenic", "substrate", ",", "C3537142#ent", "<e1>", "in", "some", "and", "C0003195#ent", "<e2>", "in", "others", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [14, 15]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [19, 20]}}
{"token": ["The", "second", "and", "third", "findings", "may", "partially", "explain", "why", "potassium", "blockade", "C3537142#ent", "<e1>", "in", "some", "patients", ",", "and", "C0003195#ent", "<e2>", "in", "others", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [11, 12]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [18, 19]}}
{"token": ["DAPI", "staining", "autolysing", "mycelia", "revealed", "numerous", "nuclei", "with", "elongated", ",", "stick-like", "morphology", ",", "which", "was", "not", "observed", "in", "C1332416#ent", "<e1>", "hyphal", "fragments", "representing", "a", "cell", "population", "to", "C0524928#ent", "<e2>", "starvation", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [27, 28]}}
{"token": ["C1825573#ent", "<e1>", "reacted", "with", "either", "C0162745#ent", "<e2>", "or", "hydroxylamine", "are", "also", "smaller", "than", "the", "parent", "C1825573#ent", "<e1>", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1825573", "name": "C1825573#ent", "pos": [0, 1]}}
{"token": ["In", "addition", ",", "purine", "inhibition", "the", "C0016424#ent", "<e1>", "response", "was", "antagonized", "by", "C0006644#ent", "<e2>", ",", "while", "the", "nonxanthine", "phosphodiesterase", "inhibitor", "Ro", "20", "-", "1724", "[", "4-(3-butoxy-4-methoxybenzyl)2-imidazolidinone", "]", "was", "without", "effect", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006644", "name": "C0006644#ent", "pos": [12, 13]}}
{"token": ["Mn", "deficiency", "not", "alter", "C1418708#ent", "<e1>", "chymotrypsin", "or", "C0041236#ent", "<e2>", "activities", "."], "h": {"id": "C1418708", "name": "C1418708#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "ambulatory", "children", "C0014547#ent", "<e1>", "taking", "VPA", "therapy", "may", "develop", "proximal", "C0015624#ent", "<e2>"], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [13, 14]}}
{"token": ["Predictors", "for", "no", "delayed", "emesis", "at", "all", "were", "anti-emetic", "treatment", "C0011777#ent", "<e1>", ",", "minimal", "tumour", "burden", ",", "low", "neuroticism", "and", "no", "history", "C0026603#ent", "<e2>"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [22, 23]}}
{"token": ["The", "frequency", "of", "proven", "C0017178#ent", "<e1>", "increased", "with", "the", "severity", "of", "the", "C0041327#ent", "<e2>"], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [12, 13]}}
{"token": ["A", "similar", "protein", "with", "an", "ability", "to", "bind", "to", "C0812385#ent", "<e1>", "was", "also", "found", "in", "C0023899#ent", "<e2>", "and", "kidney", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [15, 16]}}
{"token": ["The", "case", "history", "a", "boy", "suffering", "from", "acute", "lymphoblastic", "leukemia", "C0812385#ent", "<e1>", ")", "and", "carcinoma", "of", "the", "C0023899#ent", "<e2>", "as", "secondary", "malignoma", "reported", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [17, 18]}}
{"token": ["All", "8", "tested", "C0003299#ent", "<e1>", ",", "namely", "carbamazepine", ",", "clonazepam", ",", "diazepam", ",", "C0237417#ent", "<e2>", ",", "ethosuximide", ",", "flunarizine", ",", "phenobarbital", "and", "sodium", "valproate", "decreased", "this", "behaviour", "in", "a", "dose-dependent", "way", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0237417", "name": "C0237417#ent", "pos": [13, 14]}}
{"token": ["Several", "C0003299#ent", "<e1>", "the", "serum", "levels", "thyroid", "hormones", "different", "mechanisms", ",", "of", "these", "C0237417#ent", "<e2>", "being", "the", "most", "known", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0237417", "name": "C0237417#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "expression", "of", "both", "copies", "of", "C1706548#ent", "<e1>", "in", "place", "of", "C1705396#ent", "<e2>", "does", "not", "disrupt", "spinal", "cord", ",", "but", "does", "result", "in", "new", "gain-of-function", "defects", "that", "lead", "to", "lethality", "."], "h": {"id": "C1706548", "name": "C1706548#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705396", "name": "C1705396#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "the", "differentiation", "of", "spinal", "motor", "neurons", "be", "induced", "by", "the", "two", "ventrally", "expressed", "C1706548#ent", "<e1>", "Gli1", "and", "C1705396#ent", "<e2>", ",", "suggesting", "that", "C1705396#ent", "<e2>", "directly", "mediates", "induction", "of", "motor", "neurons", "Shh", "."], "h": {"id": "C1706548", "name": "C1706548#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705396", "name": "C1705396#ent", "pos": [20, 21]}}
{"token": ["To", "clarify", "the", "roles", "of", "C1706548#ent", "<e1>", "vertebrate", "development", "we", "have", "analyzed", "the", "requirements", "for", "gli1", "and", "C1705396#ent", "<e2>", "during", "zebrafish", "embryogenesis", "."], "h": {"id": "C1706548", "name": "C1706548#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705396", "name": "C1705396#ent", "pos": [17, 18]}}
{"token": ["In", "a", "screen", "for", "genetic", "modifiers", "C1271398#ent", "<e1>", ",", "we", "isolated", "mutations", "in", "Su(var)205", ",", "C0914122#ent", "<e2>", "-", "7", ",", "and", "two", "unidentified", "genes", "that", "suppress", "this", "variegated", "phenotype", "."], "h": {"id": "C1271398", "name": "C1271398#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0914122", "name": "C0914122#ent", "pos": [15, 16]}}
{"token": ["The", "N-terminal", "peptide", "inhibits", "the", "effect", "of", "C1428391#ent", "<e1>", "on", "the", "nascent", "C2987364#ent", "<e2>", "rhodanese", "and", "blocks", "the", "chaperone-mediated", "release", "and", "activation", "of", "ribosome-bound", "full-length", "rhodanese", "polypeptides", "that", "accumulate", "during", "in", "vitro", "synthesis", "."], "h": {"id": "C1428391", "name": "C1428391#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}}
{"token": ["The", "amnion", ",", "chorion", "and", "decidua", "all", "contain", "mRNA", "for", "the", "newly-discovered", "inducible", "form", "of", "C0033551#ent", "<e1>", "PGHS-2", ")", "as", "well", "as", "mRNA", "for", "the", "C0907533#ent", "<e2>", "PGHS-1", ")", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [25, 26]}}
{"token": ["Two", "isoforms", "of", "C0033551#ent", "<e1>", "(", "COX", ")", "have", "been", "identified", "in", "eukaryotic", "cells", "a", "C0907533#ent", "<e2>", "expressed", "COX-1", "and", "mitogen-inducible", "COX-2", "which", "is", "selectively", "expressed", "in", "response", "to", "various", "inflammatory", "stimuli"], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [15, 16]}}
{"token": ["Terodiline", ",", "a", "C1254351#ent", "<e1>", "with", "anticholinergic", "and", "C0006684#ent", "<e2>", "effectively", "relaxed", "carbachol-contracted", ",", "isolated", "human", "bladder", "preparations", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [8, 9]}}
{"token": ["i.e.", ",", "Drug", "A", "and", "placebo", "(", "i.e.", ",", "C1254351#ent", "<e1>", "under", "an", "instructed", "novel-response", "drug", "discrimination", "procedure", ",", "the", "C0006684#ent", "<e2>", "isradipine", "(", "0", "-", "10", "mg/70", "kg", ",", "p.o", ".", ";"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [20, 21]}}
{"token": ["The", "interaction", "of", "the", "U5-specific", "polypeptides", "with", "U5", "snRNA", "investigated", "by", "comparison", "of", "the", "differential", "accessibility", "towards", "C0035542#ent", "<e1>", "and", "dimethylsulfate", "of", "defined", "regions", "of", "U5", "snRNA", "purified", "C0208355#ent", "<e2>", "and", "10S", "U5", "snRNPs"], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0208355", "name": "C0208355#ent", "pos": [28, 29]}}
{"token": ["These", "results", "indicate", "that", "the", "beta-glucan-binding", "proteins", "French", "bean", "C0947608#ent", "<e1>", "are", "conserved", "C4277608#ent", "<e2>", "involved", "in", "beta-glucan", "elicitor", "recognition", "."], "h": {"id": "C0947608", "name": "C0947608#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [13, 14]}}
{"token": ["In", "mild", "beta", "thalassemia", "levels", "are", "much", "higher", "than", "in", "severe", "beta", "thalassemia", "yet", "black", "patients", "with", "the", "C0039082#ent", "<e1>", "as", "deficient", "in", "beta", "chain", "synthesis", "severe", "C0039730#ent", "<e2>", "patients", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0039730", "name": "C0039730#ent", "pos": [27, 28]}}
{"token": ["Cardiac", "and", "esophageal", "causes", "of", "chest", "pain", "common", ",", "but", "C0026857#ent", "<e1>", "as", "Tietze's", "syndrome", "chest", "wall", "pain", "syndromes", "fibrositis", ",", "C0003864#ent", "<e2>", "cervical", "osteoarthritis", "and", "disease", "of", "the", "thoracic", "spine", "also", "result", "in", "chest", "pain"], "h": {"id": "C0026857", "name": "C0026857#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [21, 22]}}
{"token": ["C0020550#ent", "<e1>", "was", "associated", "with", "changes", "in", "the", "expression", "of", "only", "11", "C1417679#ent", "<e2>", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["At", "the", "other", "end", "of", "the", "spectrum", ",", "C0020550#ent", "<e1>", "may", "result", "from", "gain", "of", "function", "mutations", "C1417679#ent", "<e2>", "regulating", "growth", "and", "function", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["These", "and", "additional", "partners", ",", "notably", "actin", "and", "C0027103#ent", "<e1>", "suggest", "disease-relevant", "roles", "for", "C0295734#ent", "<e2>", "in", "gene", "regulation", "the", "mechanical", "interity", "the", "nucleus", "."], "h": {"id": "C0027103", "name": "C0027103#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0295734", "name": "C0295734#ent", "pos": [14, 15]}}
{"token": ["C0011303#ent", "<e1>", "an", "important", "group", "of", "human", "C0027765#ent", "<e2>", "are", "as", "yet", "incurable", "."], "h": {"id": "C0011303", "name": "C0011303#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [7, 8]}}
{"token": ["Thus", "we", "were", "unable", "to", "distinguish", "patients", "with", "C0011303#ent", "<e1>", "normal", "individuals", "or", "from", "patients", "with", "other", "C0027765#ent", "<e2>", "terms", "of", "serum", "or", "cerebrospinal", "fluid", "anti-glial", "cell", "antibodies"], "h": {"id": "C0011303", "name": "C0011303#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [17, 18]}}
{"token": ["Multiple", "sclerosis", "MS", ")", "is", "an", "C0011303#ent", "<e1>", "the", "central", "nervous", "system", "and", "the", "most", "common", "C0027765#ent", "<e2>", "young", "adults"], "h": {"id": "C0011303", "name": "C0011303#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [16, 17]}}
{"token": ["The", "18q21.3", "breakpoint", "occurred", "between", "two", "nearly", "identical", "C0033607#ent", "<e1>", "serpin", ")", "genes", ",", "C1419844#ent", "<e2>", "and", "SCCA2", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419844", "name": "C1419844#ent", "pos": [14, 15]}}
{"token": ["Among", "the", "medical", "drugs", "C0040615#ent", "<e1>", ",", "statins", ",", "zidovudine", ",", "C0009262#ent", "<e2>", ",", "selective", "serotonin", "reuptake", "inhibitors", "and", "lithium", "were", "the", "most", "frequently", "involved", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [11, 12]}}
{"token": ["From", "comparison", "with", "other", "C0086376#ent", "<e1>", ",", "CEL-IV", "was", "apparently", "homologous", "with", "the", "C1539087#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539087", "name": "C1539087#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "at", "least", "two", "structurally", "similar", "but", "functionally", "distinct", "C0086376#ent", "<e1>", ",", "both", "belonging", "to", "the", "C1539087#ent", "<e2>", "are", "present", "in", "the", "venom", "of", "B.", "jararaca", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539087", "name": "C1539087#ent", "pos": [19, 20]}}
{"token": ["This", "was", "confirmed", "in", "an", "inhibition", "study", "in", "which", "pooled", "human", "liver", "microsomes", "were", "incubated", "with", "C0015153#ent", "<e1>", "in", "the", "presence", "and", "absence", "of", "C0027203#ent", "<e2>", "specific", "inhibitors", "."], "h": {"id": "C0015153", "name": "C0015153#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [24, 25]}}
{"token": ["To", "determine", "the", "mechanism", "of", "action", "of", "pantethine", ",", "and", "of", "C0010637#ent", "<e1>", ",", "we", "have", "compared", "the", "C1539479#ent", "<e2>", "of", "[35S]cystine-derived", "metabolites", "in", "the", "presence", "and", "absence", "of", "these", "agents", "."], "h": {"id": "C0010637", "name": "C0010637#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [18, 19]}}
{"token": ["Infection", "with", "C0018081#ent", "<e1>", "or", "other", "C0036916#ent", "<e2>", "diseases", "during", "the", "same", "pregnancy", "were", "not", "predictive", "of", "reinfection", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [6, 7]}}
{"token": ["Renal", "proximal", "distal", "tubules", "loops", "of", "Henle", "had", "more", "intense", "labelling", "for", "mRNA", "of", "MAO-B", "than", "C3657721#ent", "<e1>", ";", "this", "was", "reflected", "in", "C0026454#ent", "<e2>", "expression", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [23, 24]}}
{"token": ["1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine", "(", "MPTP", ")", "was", "studied", "as", "an", "inhibitor", "of", "C3657721#ent", "<e1>", "MAO", ")", "acting", "on", "[14C]serotonin", "as", "substrate", "and", "of", "C0026454#ent", "<e2>", "on", "[14C]phenylethylamine", "as", "substrate", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [21, 22]}}
{"token": ["It", "is", "concluded", "that", "a", "C1333909#ent", "<e1>", "+", "-sensitive", "component", "of", "the", "C0082874#ent", "<e2>", "is", "responsible", "for", "the", "folding", "of", "the", "nucleosome", "chain", "heterochromatin-specific", "supranucleosomal", "structures", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0082874", "name": "C0082874#ent", "pos": [12, 13]}}
{"token": ["The", "causative", "gene", "the", "reeler", "mouse", "is", "C1419337#ent", "<e1>", "which", "encodes", "C1419337#ent", "<e1>", "an", "extracellular", "molecule"], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419337", "name": "C1419337#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "suggest", "that", "there", "may", "be", "two", "classes", "of", "GABAergic", "neurons", "that", "can", "be", "differentiated", "by", "their", "ability", "to", "express", "C1419337#ent", "<e1>", "mRNA", "and", "C1419337#ent", "<e1>"], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1419337", "name": "C1419337#ent", "pos": [21, 22]}}
{"token": ["The", "mutations", "disrupt", "splicing", "of", "C1419337#ent", "<e1>", "cDNA", ",", "resulting", "in", "low", "or", "undetectable", "amounts", "of", "C1419337#ent", "<e1>"], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419337", "name": "C1419337#ent", "pos": [5, 6]}}
{"token": ["C0005716#ent", "<e1>", "is", "a", "uncommonly", "diagnosed", "but", "important", "C0026946#ent", "<e2>", "the", "south-central", "and", "midwestern", "United", "States"], "h": {"id": "C0005716", "name": "C0005716#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [8, 9]}}
{"token": ["C0005716#ent", "<e1>", "is", "one", "of", "the", "most", "common", "systemic", "C0026946#ent", "<e2>", "dogs", "in", "North", "America", "but", "it", "is", "rarely", "diagnosed", "in", "cats", "."], "h": {"id": "C0005716", "name": "C0005716#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [9, 10]}}
{"token": ["To", "delineate", "a", "possible", "mechanism", "of", "action", "for", "C4283784#ent", "<e1>", ",", "we", "have", "recently", "shown", "that", "the", "C0003693#ent", "<e2>", "5-hydroxyeicosatetraenoic", "acid", "5-HETE", ")", ",", "could", "play", "a", "role", "in", "C4283784#ent", "<e1>", "alteration", "of", "mammary", "tumorigenesis"], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [8, 9]}}
{"token": ["MAPK", "activation", "was", "essential", "for", "L1-dependent", "neurite", "outgrowth", "because", "C3494348#ent", "<e1>", "2-(2'-amino-3'-methoxyphenyl)-oxanaphthalen-4-one", "and", "1,4-diamino-2", ",", "3-dicyano-1,4-bis(2-aminophenylthio)butadiene", "]", "of", "the", "MAPK", "kinase", "C0752313#ent", "<e2>", "strongly", "suppressed", "neurite", "outgrowth", "by", "cerebellar", "neurons", "L1", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [21, 22]}}
{"token": ["The", "signal", "transduction", "pathways", "were", "evaluated", "by", "specific", "C3494348#ent", "<e1>", "of", "the", "phosphatidylinositol", "3-kinase", "PI3K", ",", "mitogen-activated", "protein", "kinase", "kinase", "C0752313#ent", "<e2>", ")", ",", "and", "Janus", "kinase", "2", "JAK2", ")", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "synRas", "mice", "showed", "an", "increased", "synaptic", "long-term", "potentiation", ",", "which", "was", "sensitive", "to", "C3494348#ent", "<e1>", "of", "NMDA-receptors", "and", "of", "C0752313#ent", "<e2>", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [21, 22]}}
{"token": ["Loperamide", ",", "a", "novel", "C0003292#ent", "<e1>", "was", "compared", "with", "C0282145#ent", "<e2>", "in", "a", "double", "blind", "crossover", "study", "23", "patients", "with", "chronic", "diarrhea", "various", "etiologies", "."], "h": {"id": "C0003292", "name": "C0003292#ent", "pos": [4, 5]}, "relation": "therapeutic_class_of", "t": {"id": "C0282145", "name": "C0282145#ent", "pos": [9, 10]}}
{"token": ["On", "the", "basis", "of", "these", "observations", ",", "the", "combination", "of", "C0006491#ent", "<e1>", "with", "promethazine", "and", "C1161352#ent", "<e2>", "appears", "safe", "and", "useful", "for", "pre-anaesthetic", "medication", "."], "h": {"id": "C0006491", "name": "C0006491#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [15, 16]}}
{"token": ["rpc160", "-", "112", ",", "a", "mutant", "of", "the", "C0035679#ent", "<e1>", "active", "site", "is", "corrected", "in", "vivo", "six", "C0017372#ent", "<e2>", "mutants", "obtained", "by", "random", "mutagenesis"], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017372", "name": "C0017372#ent", "pos": [17, 18]}}
{"token": ["Such", "a", "tumor", "causes", "C0005745#ent", "<e1>", "and", "this", "can", "lead", "to", "refraction", "error", "C0002418#ent", "<e2>", "."], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002418", "name": "C0002418#ent", "pos": [13, 14]}}
{"token": ["The", "infiltration", "of", "the", "upper", "eyelid", "C0005745#ent", "<e1>", "needs", "to", "be", "treated", "because", "of", "the", "risk", "of", "C0002418#ent", "<e2>", "."], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002418", "name": "C0002418#ent", "pos": [17, 18]}}
{"token": ["Both", "arterial", "(", "cerebrovascular", ",", "carotid", ",", "coronary", ",", "and", "peripheral", "arterial", "and", "C0019156#ent", "<e1>", "jointly", "termed", "C0750145#ent", "<e2>", "VOD", ")", "in", "this", "review", ",", "have", "been", "associated", "with", "hyperhomocysteinemia", "."], "h": {"id": "C0019156", "name": "C0019156#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0750145", "name": "C0750145#ent", "pos": [17, 18]}}
{"token": ["Immunoblotting", "with", "C1701621#ent", "<e1>", "sodium", "dodecyl", "sulfate-polyacrylamide", "gel", "electrophoresis", "hydrogen", "peroxide-treated", "microsomes", "or", "purified", "C0017837#ent", "<e2>", "the", "presence", "of", "a", "glutathione", "S-transferase", "dimer"], "h": {"id": "C1701621", "name": "C1701621#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [14, 15]}}
{"token": ["In", "vertebrates", "a", "central", "role", "in", "muscle", "differentiation", "played", "by", "the", "C1417574#ent", "<e1>", "a", "group", "of", "transcription", "factors", "activate", "transcription", "of", "C3815103#ent", "<e2>", "."], "h": {"id": "C1417574", "name": "C1417574#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3815103", "name": "C3815103#ent", "pos": [21, 22]}}
{"token": ["High-purity", "factor", "IX", "concentrates", "are", "available", "and", "are", "the", "treatment", "of", "choice", "for", "patients", "with", "C0019069#ent", "<e1>", "the", "absence", "of", "a", "source", "of", "C2826076#ent", "<e2>"], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C2826076", "name": "C2826076#ent", "pos": [23, 24]}}
{"token": ["The", "results", "show", "a", "nocivity", "threshold", "for", "the", "C0040416#ent", "<e1>", "at", "around", "55", "C1335641#ent", "<e2>", "and", "for", "the", "teachers", "at", "aroung", "65", "C1335641#ent", "<e2>", "."], "h": {"id": "C0040416", "name": "C0040416#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335641", "name": "C1335641#ent", "pos": [13, 14]}}
{"token": ["Mass", "spectrometry", "17", "differentially", "expressed", "proteins", ",", "including", "some", "well-studied", "proteins", "as", "well", "as", "some", "novel", "C1418296#ent", "<e1>", "related", "proteins", ",", "such", "as", "caspases", ",", "C1313038#ent", "<e2>", "elongation", "factor", "heat", "shock", "protein", "and", "hypothetical", "proteins", "."], "h": {"id": "C1418296", "name": "C1418296#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1313038", "name": "C1313038#ent", "pos": [25, 26]}}
{"token": ["Psychotic", "group", "read", "that", "the", "person", "was", "on", "haloperidol", ",", "C0005098#ent", "<e1>", ",", "lorazepam", ",", "trazadone", ",", "C0016365#ent", "<e2>", ",", "and", "lithium", "."], "h": {"id": "C0005098", "name": "C0005098#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "alpha-difluoromethylornithine", "(", "C0002260#ent", "<e1>", ";", "RMI", "71782", ")", "in", "combination", "with", "C0042683#ent", "<e2>", "or", "Adriamycin", "were", "investigated", "in", "three", "different", "animal", "tumor", "models", "."], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042683", "name": "C0042683#ent", "pos": [14, 15]}}
{"token": ["The", "metabolism", "of", "C0007248#ent", "<e1>", "to", "meprobamate", "is", "dependent", "on", "C0960580#ent", "<e2>", "genotype", "."], "h": {"id": "C0007248", "name": "C0007248#ent", "pos": [3, 4]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [10, 11]}}
{"token": ["Individuals", "with", "Supravalvular", "aortic", "stenosis", "SVAS", ")", "and", "Williams", "syndrome", "WS", ")", "lack", "one", "normal", "C1414382#ent", "<e1>", "C1706112#ent", "<e2>", "due", "to", "heterozygous", "C1414382#ent", "<e1>", "abnormalities", ",", "resulting", "in", "a", "haploinsufficiency", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [15, 16]}}
{"token": ["Uniparental", "paternal", "disomy", "11p15.5", "or", "altered", "expression", "of", "insulin-like", "growth", "factor", "2", "IGF2", ")", "from", "the", "normally", "silent", "maternal", "C1706112#ent", "<e1>", "have", "been", "implicated", "as", "causes", "of", "some", "cases", "of", "C1414382#ent", "<e2>", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [30, 31]}}
{"token": ["A", "truncated", "version", "of", "E4/E8BP-1", "was", "able", "to", "transactivate", "the", "E4", "promoter", "transient", "assay", "demonstrating", "that", "this", "C1413746#ent", "<e1>", "interact", "with", "the", "E4", "promoter", "in", "vivo", "enhance", "C0812327#ent", "<e2>"], "h": {"id": "C1413746", "name": "C1413746#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [27, 28]}}
{"token": ["After", "translocation", "to", "the", "nucleus", ",", "the", "Notch", "ICD", "with", "the", "C1413746#ent", "<e1>", "CSL", "to", "activate", "C0812327#ent", "<e2>"], "h": {"id": "C1413746", "name": "C1413746#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [16, 17]}}
{"token": ["C0030809#ent", "<e1>", "PV", ")", "is", "an", "autoimmune", "blistering", "disease", "by", "IgG", "autoantibodies", "desmoglein", "3", "C1414170#ent", "<e2>", ")", "."], "h": {"id": "C0030809", "name": "C0030809#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414170", "name": "C1414170#ent", "pos": [14, 15]}}
{"token": ["C0030809#ent", "<e1>", "characterized", "by", "IgG", "autoantibodies", "C1414170#ent", "<e2>", "Dsg", "3", ",", "whereas", "the", "target", "of", "PF", "is", "Dsg1", ",", "although", "about", "50", "%", "of", "PV", "patients", "also", "have", "Dsg1", "autoantibodies"], "h": {"id": "C0030809", "name": "C0030809#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414170", "name": "C1414170#ent", "pos": [6, 7]}}
{"token": ["To", "explain", "this", "apparent", "paradox", ",", "we", "C0030809#ent", "<e1>", "sera", "with", "the", "extracellular", "domains", "C1414170#ent", "<e2>", "and", "desmoglein", "1", "Dsg1", ")", "produced", "by", "insect", "cells", "infected", "with", "recombinant", "baculovirus"], "h": {"id": "C0030809", "name": "C0030809#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414170", "name": "C1414170#ent", "pos": [14, 15]}}
{"token": ["Kufs'", "disease", "adult", "C1864923#ent", "<e1>", "is", "a", "rare", "form", "of", "C0524851#ent", "<e2>", "the", "genetic", "basis", "which", "remains", "obscure", "."], "h": {"id": "C1864923", "name": "C1864923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524851", "name": "C0524851#ent", "pos": [10, 11]}}
{"token": ["A", "lupus-like", "syndrome", "chronic", "urticaria", "cutaneous", "vasculitis", "systemic", "symptoms", "C0853888#ent", "<e1>", "with", "preferential", "depletion", "of", "C1412931#ent", "<e2>", ",", "and", "low", "m.w", "."], "h": {"id": "C0853888", "name": "C0853888#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412931", "name": "C1412931#ent", "pos": [15, 16]}}
{"token": ["A", "mixture", "containing", "3", "g", "of", "boric", "acid", "300", "mg", "of", "C0012050#ent", "<e1>", "prescribed", "due", "to", "C0030193#ent", "<e2>", "dental", "protrusion", "accidentally", "ingested", "by", "a", "12-month-old", "girl", "."], "h": {"id": "C0012050", "name": "C0012050#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [16, 17]}}
{"token": ["We", "conclude", "that", "both", "loperamide", "and", "C0009217#ent", "<e1>", "superior", "to", "C0282145#ent", "<e2>", "in", "the", "symptomatic", "treatment", "of", "chronic", "diarrhea"], "h": {"id": "C0009217", "name": "C0009217#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0282145", "name": "C0282145#ent", "pos": [10, 11]}}
{"token": ["Interestingly", ",", "we", "observed", "phosphorylation", "of", "phospholipase", "C", "gamma-1", "CG-4", "and", "C6", "cells", ",", "and", "phosphorylation", "of", "C2936824#ent", "<e1>", "C6", "cells", "in", "the", "presence", "of", "C1706578#ent", "<e2>", "."], "h": {"id": "C2936824", "name": "C2936824#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1706578", "name": "C1706578#ent", "pos": [25, 26]}}
{"token": ["was", "an", "C1563717#ent", "<e1>", "and", "inhibited", "the", "C0596110#ent", "<e2>", "and", "antidiuretic", "effects", "PGE2", "."], "h": {"id": "C1563717", "name": "C1563717#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "HA", "rats", "may", "have", "either", "an", "excess", "renal", "action", "C1563717#ent", "<e1>", "and", "antinatriuretic", "factors", "an", "insufficient", "renal", "action", "C0596110#ent", "<e2>", "and", "natriuretic", "factors", "NE", "administration", "."], "h": {"id": "C1563717", "name": "C1563717#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [22, 23]}}
{"token": ["Studies", "that", "used", "cholestyramine", "and", "the", "combination", "of", "C0354648#ent", "<e1>", "and", "niacin", "resulted", "in", "decreased", "progression", "of", "C1956346#ent", "<e2>"], "h": {"id": "C0354648", "name": "C0354648#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [17, 18]}}
{"token": ["In", "addition", "to", "its", "role", "as", "a", "C1268567#ent", "<e1>", "JSI-124", "appears", "to", "be", "involved", "in", "regulating", "C0208355#ent", "<e2>", "degradation", "for", "proteins", "such", "as", "JAK3", "and", "NPM-ALK", "."], "h": {"id": "C1268567", "name": "C1268567#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0208355", "name": "C0208355#ent", "pos": [16, 17]}}
{"token": ["C0015468#ent", "<e1>", "been", "considered", "a", "common", "symptom", "of", "C0039494#ent", "<e2>", "TMD", ")", "with", "a", "multifactorial", "etiology", "."], "h": {"id": "C0015468", "name": "C0015468#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039494", "name": "C0039494#ent", "pos": [8, 9]}}
{"token": ["Three", "C1414404#ent", "<e1>", "show", "positive", "regulation", "are", "derived", "from", "the", "GABA(A)", "receptor", "gamma2", "subunit", "24", "nucleotide", "exon", "C1413511#ent", "<e2>", "EN", ",", "and", "N-methyl-D-aspartate", "receptor", "NR1", "subunit", "exon", "5", "pre-mRNAs", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413511", "name": "C1413511#ent", "pos": [17, 18]}}
{"token": ["The", "localization", "of", "5", "C0039602#ent", "<e1>", "within", "the", "nuclear", "envelope", "rat", "ventral", "prostate", "an", "C0021699#ent", "<e2>", "to", "be", "of", "physiological", "significance", "regard", "to", "the", "action", "of", "androgens", "."], "h": {"id": "C0039602", "name": "C0039602#ent", "pos": [4, 5]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [14, 15]}}
{"token": ["SNEV", "(", "Prp19", ",", "Pso4", ",", "NMP200", ")", "is", "a", "C2985428#ent", "<e1>", "to", "be", "involved", "in", "pre-mRNA", "splicing", "ubiquitylation", ",", "and", "C1333237#ent", "<e2>"], "h": {"id": "C2985428", "name": "C2985428#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [21, 22]}}
{"token": ["Our", "aim", "was", "to", "investigate", "whether", "TARDBP", "is", "a", "candidate", "C0019247#ent", "<e1>", "familial", "ALS", "that", "is", "not", "associated", "with", "mutations", "in", "superoxide", "dismutase", "1", "C1420306#ent", "<e2>", ")", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [24, 25]}}
{"token": ["Among", "the", "drugs", ",", "C0003195#ent", "<e1>", "notably", "quinidine", ",", "sotalol", ",", "C0114771#ent", "<e2>", "and", "ibutilide", "have", "the", "potential", "to", "induce", "the", "fatal", "torsade", "de", "pointes"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [4, 5]}, "relation": "therapeutic_class_of", "t": {"id": "C0114771", "name": "C0114771#ent", "pos": [11, 12]}}
{"token": ["The", "majority", "of", "C0003195#ent", "<e1>", "including", "sotalol", ",", "C0114771#ent", "<e2>", ",", "and", "azimilide", ",", "have", "no", "effect", ",", "or", "are", "even", "associated", "with", "decrease", "in", ",", "defibrillation", "thresholds", "humans", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0114771", "name": "C0114771#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "basement", "membrane-associated", "collagen", "from", "C1332774#ent", "<e1>", "that", "basement", "membrane-associated", "collagen", "a", "good", "marker", "of", "C0268747#ent", "<e2>", "expansion", "in", "diabetic", "nephropathy"], "h": {"id": "C1332774", "name": "C1332774#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268747", "name": "C0268747#ent", "pos": [18, 19]}}
{"token": ["Tissue", "inhibitor", "metalloproteinases-2", "(", "C1336629#ent", "<e1>", ")", "is", "a", "natural", "inhibitor", "several", "C0030946#ent", "<e2>", "that", "are", "involved", "in", "the", "degradation", "of", "the", "extracellular", "matrix"], "h": {"id": "C1336629", "name": "C1336629#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [12, 13]}}
{"token": ["Implementation", "of", "a", "hospital", "policy", "health", "care", "workers", "exposed", "to", "C3854222#ent", "<e1>", "HIV", ")", "or", "C0019158#ent", "<e2>", "is", "discussed", ",", "using", "a", "model", "program", "by", "San", "Francisco", "General", "Hospital", "(", "SFGH", ")", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [15, 16]}}
{"token": ["The", "law", "is", "intended", "to", "reduce", "the", "transmission", "of", "C3854222#ent", "<e1>", "HIV", ")", "and", "C0019158#ent", "<e2>", "among", "injection", "drug", "users", "IDUs", ")", ",", "their", "sexual", "partners", "and", "their", "children", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [14, 15]}}
{"token": ["Improved", "techniques", "in", "esophageal", "manometry", "made", "this", "test", "an", "attractive", "option", "for", "investigating", "pharyngeal", "or", "C0014852#ent", "<e1>", "patients", "with", "C0011168#ent", "<e2>", "."], "h": {"id": "C0014852", "name": "C0014852#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [19, 20]}}
{"token": ["Heparins", "exert", "their", "C0003280#ent", "<e1>", "effect", "by", "enhancing", "C3538795#ent", "<e2>", "inhibitory", "action", "on", "factor", "Xa", "thrombin", ",", "which", "results", "in", "decreased", "factor", "X", "activation", ",", "prothrombinase", "formation", "prothrombin", "activation", "thrombin", "generation"], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538795", "name": "C3538795#ent", "pos": [8, 9]}}
{"token": ["Management", "of", "high", "TAT", "began", "with", "the", "use", "of", "an", "C0003280#ent", "<e1>", "such", "as", "heparin", "under", "the", "condition", "of", "sufficient", "C3538795#ent", "<e2>", "level", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3538795", "name": "C3538795#ent", "pos": [20, 21]}}
{"token": ["Endocrine", "evaluation", "of", "measuring", "adrenocorticotropic", "hormone", "ACTH", ")", ",", "cortisol", ",", "and", "growth", "hormone", "GH", ")", "levels", "during", "C1864903#ent", "<e1>", "IHT", ")", "and", "after", "administration", "of", "C1366488#ent", "<e2>", "CRH", ")", "and", "growth", "hormone-releasing", "hormone", "GRH", ")", "."], "h": {"id": "C1864903", "name": "C1864903#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1366488", "name": "C1366488#ent", "pos": [26, 27]}}
{"token": ["Deltaxyl1", "strains", "show", "reduced", "growth", "on", "lactose", "and", "are", "impaired", "in", "C0005220#ent", "<e1>", "expression", "and", "induction", "of", "the", "major", "C0059939#ent", "<e2>"], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0059939", "name": "C0059939#ent", "pos": [19, 20]}}
{"token": ["Comparison", "of", "survival", "curve", "clinical", "type", "poorer", "survival", "in", "C0272170#ent", "<e1>", "and", "SND", "than", "in", "C0752120#ent", "<e2>", "cases", "."], "h": {"id": "C0272170", "name": "C0272170#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752120", "name": "C0752120#ent", "pos": [15, 16]}}
{"token": ["Symptoms", "and", "signs", "of", "extrapyramidal", "system", "SND", "greater", "than", "C0272170#ent", "<e1>", "greater", "than", "C0752120#ent", "<e2>", ",", "autonomic", "dysfunction", "C0272170#ent", "<e1>", "greater", "than", "C0752120#ent", "<e2>", "greater", "than", "SND", "."], "h": {"id": "C0272170", "name": "C0272170#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752120", "name": "C0752120#ent", "pos": [13, 14]}}
{"token": ["Micturitional", "symptoms", "C0272170#ent", "<e1>", "appeared", "earlier", "than", "those", "in", "SND", "or", "C0752120#ent", "<e2>", "."], "h": {"id": "C0272170", "name": "C0272170#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752120", "name": "C0752120#ent", "pos": [11, 12]}}
{"token": ["Thrombocytopenia", ",", "coagulopathy", ",", "and", "C0019158#ent", "<e1>", "were", "typical", "C0029166#ent", "<e2>"], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [9, 10]}}
{"token": ["We", "present", "here", "a", "case", "of", "cat-scratch", "disease", "associated", "with", "pleural", "effusion", "C0019158#ent", "<e1>", "and", "other", "C0029166#ent", "<e2>", "by", "identification", "of", "the", "coccobacillus", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [16, 17]}}
{"token": ["PCR", "karyotyping", "refined", "the", "region", "on", "chromosome", "6", "identified", "CRSP3/DRIP130", ",", "a", "C1425716#ent", "<e1>", "as", "a", "C1426941#ent", "<e2>"], "h": {"id": "C1425716", "name": "C1425716#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1426941", "name": "C1426941#ent", "pos": [16, 17]}}
{"token": ["This", "paper", "concentrates", "on", "the", "problem", "of", "separating", "acute", "appendicitis", "which", "is", "a", "special", "problem", "of", "C0740577#ent", "<e1>", "from", "other", "C0029896#ent", "<e2>", "that", "cause", "C0740577#ent", "<e1>", "use", "of", "an", "decision", "tree", "approach"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0740577", "name": "C0740577#ent", "pos": [16, 17]}}
{"token": ["This", "article", "discusses", "the", "role", "of", "ultrasound", "for", "the", "diagnosis", "of", "the", "most", "common", "C0029896#ent", "<e1>", "that", "can", "produce", "clinical", "signs", "C0740577#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0740577", "name": "C0740577#ent", "pos": [21, 22]}}
{"token": ["Generally", ",", "laparoscopy", "is", "well", "suited", "for", "the", "therapy", "of", "the", "majority", "of", "C0029896#ent", "<e1>", "that", "cause", "C0740577#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0740577", "name": "C0740577#ent", "pos": [17, 18]}}
{"token": ["The", "disease", "syndromes", "by", "S.", "suis", "swine", "include", "arthritis", ",", "C0025289#ent", "<e1>", ",", "pneumonia", ",", "septicaemia", ",", "endocarditis", ",", "C0031069#ent", "<e2>", ",", "abortions", "and", "abscesses", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "suggest", "that", "C0025289#ent", "<e1>", "should", "be", "considered", "as", "an", "unusual", "manifestation", "of", "C0031069#ent", "<e2>"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [14, 15]}}
{"token": ["C0344191#ent", "<e1>", "is", "a", "C0009450#ent", "<e2>", "horses", ",", "cattle", ",", "and", "sheep", "."], "h": {"id": "C0344191", "name": "C0344191#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [4, 5]}}
{"token": ["These", "findings", "were", "obtained", "in", "rats", "infected", "with", "either", "Plasmodium", "berghei", "Plasmodium", "vinckei", "when", "the", "C0012177#ent", "<e1>", "in", "the", "form", "of", "C0007332#ent", "<e2>", "or", "albumin", ";", "and", "when", "well-nourished", "or", "previously", "undernourished", "animals", "used", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [15, 16]}, "relation": "structural_class_of", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [21, 22]}}
{"token": ["In", "experiments", "using", "high", "fat", "diets", "the", "amino", "acid", "compositions", "of", "C0012177#ent", "<e1>", "soya", "or", "C0007332#ent", "<e2>", ")", "were", "altered", "by", "blending", "them", "1:1", "(", "w/w", ")", "with", "gelatin", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [11, 12]}, "relation": "structural_class_of", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [15, 16]}}
{"token": ["Feeding", "a", "low-fat", "diet", "free", "of", "cholesterol", "rats", "resulted", "in", "a", "low", "level", "of", "serum", "cholesterol", "apolipoprotein", "A-1", "apoA-I", ")", "when", "C0012177#ent", "<e1>", "soybean", "protein", "compared", "to", "C0007332#ent", "<e2>", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [21, 22]}, "relation": "structural_class_of", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [27, 28]}}
{"token": ["This", "syndrome", "can", "imitate", "C0017160#ent", "<e1>", ",", "encephalitis", ",", "syncope", ",", "C0154723#ent", "<e2>", ",", "sleep", "disorders", "metabolic", "diseases"], "h": {"id": "C0017160", "name": "C0017160#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0154723", "name": "C0154723#ent", "pos": [11, 12]}}
{"token": ["C3539185#ent", "<e1>", "were", "first", "prescribed", "for", "preterm", "neonates", "treat", "C0852283#ent", "<e2>", "but", "they", "were", "found", "to", "have", "no", "beneficial", "effect", "in", "this", "disorder", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0852283", "name": "C0852283#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "the", "combination", "of", "low-dose", "mirtazapine", "and", "C0020740#ent", "<e1>", "is", "not", "effective", "for", "the", "treatment", "of", "C0033893#ent", "<e2>"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033893", "name": "C0033893#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "the", "study", "suggests", "that", "daily", "intake", "of", "C0020740#ent", "<e1>", "worsens", "headache", "already", "after", "few", "weeks", "in", "C0033893#ent", "<e2>"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033893", "name": "C0033893#ent", "pos": [18, 19]}}
{"token": ["C0265224#ent", "<e1>", "also", "called", "\"", "whistling-face", "syndrome", "\"", "is", "a", "very", "rare", "C0019247#ent", "<e2>", "occurring", "both", "sporadically", "and", "by", "transmission", "through", "autosomal", "dominant", "recessive", "mode", "which", "affects", "primarily", "the", "face", "and", "skeleton", "."], "h": {"id": "C0265224", "name": "C0265224#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [12, 13]}}
{"token": ["Freeman-Sheldon", "syndrome", "also", "called", "\"", "C0265224#ent", "<e1>", "\"", "is", "a", "very", "rare", "C0019247#ent", "<e2>", "occurring", "both", "sporadically", "and", "by", "transmission", "through", "autosomal", "dominant", "recessive", "mode", "which", "affects", "primarily", "the", "face", "and", "skeleton", "."], "h": {"id": "C0265224", "name": "C0265224#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "these", "kinases", "requires", "both", "C1333735#ent", "<e1>", "independent", "pathways", ",", "reactive", "oxygen", "species", "a", "metalloprotease", ",", "and", "each", "C0031727#ent", "<e2>", "could", "be", "involved", "specifically", "in", "mediating", "pathophysiological", "function", "the", "AT1", "receptor", "target", "organs", "."], "h": {"id": "C1333735", "name": "C1333735#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "C0085631#ent", "<e1>", "speed", "and", "air", "flow", "rate", "on", "C1947941#ent", "<e2>", "yield", "suggested", "that", "the", "rate", "of", "O2", "transfer", "air", "to", "medium", "could", "limit", "the", "rate", "of", "C1947941#ent", "<e2>", "production", "."], "h": {"id": "C0085631", "name": "C0085631#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [11, 12]}}
{"token": ["Closely", "controlled", ",", "long-term", "studies", "conducted", "in", "large", "numbers", "of", "patients", "are", "warranted", "in", "order", "to", "determine", "the", "exact", "therapeutic", "role", "of", "C0009262#ent", "<e1>", "the", "long-term", "management", "of", "C0033860#ent", "<e2>", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [28, 29]}}
{"token": ["This", "NLS", "is", "conserved", "across", "species", ",", "among", "a", "subfamily", "of", "C2699748#ent", "<e1>", "Brachyury", "and", "C1420603#ent", "<e2>", ",", "and", "among", "additional", "nuclear", "proteins"], "h": {"id": "C2699748", "name": "C2699748#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420603", "name": "C1420603#ent", "pos": [15, 16]}}
{"token": ["Vulvar", "dermatoses", "previously", "dystrophies", ")", "include", "C0033860#ent", "<e1>", ",", "allergic", "or", "irritant", "reactions", "lichen", "sclerosus", "lichen", "simplex", "chronicus", "lichen", "planus", "and", "C0040247#ent", "<e2>", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [21, 22]}}
{"token": ["To", "investigate", "this", "issue", ",", "the", "opiate", "antagonist", "naloxone", "was", "administered", "to", "8", "normals", "and", "14", "patients", "with", "C0221043#ent", "<e1>", "6", "with", "an", "aldosterone-producing", "adenoma", "C1425411#ent", "<e2>", ")", "and", "8", "with", "IHA", "."], "h": {"id": "C0221043", "name": "C0221043#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1425411", "name": "C1425411#ent", "pos": [25, 26]}}
{"token": ["To", "further", "investigate", "this", "issue", ",", "the", "opiate", "receptor", "antagonist", "naloxone", "was", "administered", "to", "14", "patients", "with", "C0221043#ent", "<e1>", "6", "with", "an", "aldosterone-producing", "adenoma", "C1425411#ent", "<e2>", ")", "and", "8", "with", "IHA", "."], "h": {"id": "C0221043", "name": "C0221043#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1425411", "name": "C1425411#ent", "pos": [24, 25]}}
{"token": ["Five", "developed", "severe", "C0020625#ent", "<e1>", "superimposed", "on", "C0268007#ent", "<e2>", "to", "a", "reset", "osmostat", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268007", "name": "C0268007#ent", "pos": [7, 8]}}
{"token": ["This", "case", "shows", "that", "in", "the", "management", "of", "severe", "C0020625#ent", "<e1>", ",", "the", "discrimination", "between", "acute", "and", "C0268007#ent", "<e2>", "to", "be", "important", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268007", "name": "C0268007#ent", "pos": [17, 18]}}
{"token": ["Experience", "with", "use", "of", "these", "agents", "for", "treatment", "of", "acute", ",", "severe", ",", "life-threatening", "C0020625#ent", "<e1>", "as", "well", "as", "C0268007#ent", "<e2>", "limited", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0268007", "name": "C0268007#ent", "pos": [19, 20]}}
{"token": ["Unless", "diuretics", "are", "needed", "for", "reasons", "other", "than", "hypertension", ",", "treatment", "of", "diabetics", "with", "C0008273#ent", "<e1>", "should", "be", "avoided", "until", "the", "influence", "of", "these", "C0991617#ent", "<e2>", "on", "prognosis", "is", "clarified", "."], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [24, 25]}}
{"token": ["In", "this", "article", ",", "Dr", "Rosenson", "discusses", "the", "rationale", "for", "C0151718#ent", "<e1>", "patients", "with", "C0011849#ent", "<e2>", ",", "the", "lipoprotein", "abnormalities", "accompany", "insulin", "resistance", "and", "the", "prognostic", "significance", "high", "LDL", "particle", "numbers", "."], "h": {"id": "C0151718", "name": "C0151718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}}
{"token": ["Genetic", "polymorphisms", "neuronal", "nitric", "oxide", "synthase", "C1417759#ent", "<e1>", ")", "and", "calmodulin-dependent", "endothelial", "NOS", "(", "NOS3", ")", "C1417679#ent", "<e2>", "are", "known", "to", "influence", "the", "course", "of", "allergic", "respiratory", "disorders"], "h": {"id": "C1417759", "name": "C1417759#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["Low", "density", "lipoprotein", "receptor-related", "protein", "C1417509#ent", "<e1>", ")", "is", "a", "member", "of", "the", "C1366529#ent", "<e2>", "which", "functions", "as", "an", "endocytic", "receptor", "diverse", "ligands", "."], "h": {"id": "C1417509", "name": "C1417509#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366529", "name": "C1366529#ent", "pos": [13, 14]}}
{"token": ["Esophageal", "manometry", "crucial", "in", "the", "evaluation", "of", "patients", "suspected", "of", "having", "C0002962#ent", "<e1>", "but", "in", "whom", "there", "is", "no", "discernible", "evidence", "of", "C0018799#ent", "<e2>"], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [22, 23]}}
{"token": ["Currently", ",", "C0069758#ent", "<e1>", "is", "used", "in", "an", "C0003216#ent", "<e2>", "preparation", "for", "the", "topical", "relief", "of", "pain", "in", "conditions", "such", "as", "hiatus", "hernia", "where", "the", "local", "pH", "is", "very", "low", "."], "h": {"id": "C0069758", "name": "C0069758#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003216", "name": "C0003216#ent", "pos": [8, 9]}}
{"token": ["Rta", ",", "the", "gene", "product", "Kaposi's", "sarcoma-associated", "herpesvirus", "C3891713#ent", "<e1>", ")", "encoded", "mainly", "in", "C0079941#ent", "<e2>", "ORF50", ")", ",", "is", "capable", "of", "activating", "expression", "of", "viral", "lytic", "cycle", "genes"], "h": {"id": "C3891713", "name": "C3891713#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [14, 15]}}
{"token": ["The", "mouse", "gene", "C1744370#ent", "<e1>", "encodes", "the", "C1335554#ent", "<e2>", "PTP-SL", "and", "PTPBR7", "."], "h": {"id": "C1744370", "name": "C1744370#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [7, 8]}}
{"token": ["C0339164#ent", "<e1>", "the", "only", "C0730362#ent", "<e2>", "involve", "solely", "Type-1", "hypersensitivity", "the", "other", "main", "forms", "of", "ocular", "allergy", "perennial", "allergic", "conjunctivitis", "vernal", "and", "atopic", "keratoconjunctivitis", "giant", "papillary", "conjunctivitis", "each", "having", "a", "more", "complex", "immunological", "basis", "and", "a", "chronic", "inflammatory", "component"], "h": {"id": "C0339164", "name": "C0339164#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0730362", "name": "C0730362#ent", "pos": [4, 5]}}
{"token": ["A", "comparative", "controlled", "study", "carried", "out", "in", "40", "patients", "suffering", "from", "C0003873#ent", "<e1>", "osteoarthrosis", "or", "ankylosing", "spondylitis", "assess", "the", "efficacy", "of", "ketoprofen", "and", "C0020740#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [23, 24]}}
{"token": ["Aspirin", "is", "still", "the", "preferred", "treatment", "for", "C0003873#ent", "<e1>", "should", "be", "tried", "before", "C0020740#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [13, 14]}}
{"token": ["Two-hundred", "and", "eighteen", "individuals", "with", "C0003873#ent", "<e1>", "randomly", "assigned", "to", "six", "months", "treatment", "with", "C0020740#ent", "<e2>", "(", "900", "-", "1800", "mg/day", ")", "or", "indomethacin", "(", "75", "-", "150", "mg/day", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [14, 15]}}
{"token": ["Thirty", "patients", "with", "classical", "or", "definite", "C0003873#ent", "<e1>", "given", "indoprofen", "800", "mg/day", ",", "C0020740#ent", "<e2>", "1200", "mg/day", "or", "placebo", "in", "a", "double-blind", "cross-over", "trial", ",", "for", "three", "consecutive", "10-day", "periods", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [13, 14]}}
{"token": ["Brain", "C0242704#ent", "<e1>", "neurons", "play", "important", "roles", "in", "tracheal", "tone", "C0085096#ent", "<e2>", "H(1", ")", "receptors", "in", "the", "RVLM", "and", "homeostasis", "on", "body", "temperature"], "h": {"id": "C0242704", "name": "C0242704#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [10, 11]}}
{"token": ["Whether", "brain", "C0242704#ent", "<e1>", "neurons", "contribute", "to", "the", "regulation", "of", "tracheal", "tone", "C0085096#ent", "<e2>", "hyperthermia", "was", "investigated", "in", "anesthetized", "rabbits", "."], "h": {"id": "C0242704", "name": "C0242704#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [12, 13]}}
{"token": ["Although", "experience", "with", "C0121902#ent", "<e1>", "is", "limited", ",", "the", "absence", "of", "effective", "clinically", "available", "alternatives", "and", "the", "demonstrated", "efficacy", "of", "C0121902#ent", "<e1>", "justifies", "its", "place", "as", "a", "first-line", "therapy", "patients", "with", "C0034013#ent", "<e1>"], "h": {"id": "C0121902", "name": "C0121902#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0034013", "name": "C0034013#ent", "pos": [31, 32]}}
{"token": ["He", "showed", "signs", "of", "acute", "renal", "failure", "C1705280#ent", "<e1>", ")", "with", "severe", "C0011603#ent", "<e2>", "of", "his", "right", "arm"], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011603", "name": "C0011603#ent", "pos": [12, 13]}}
{"token": ["Abnormal", "retention", "of", "C3714642#ent", "<e1>", "and", "water", "in", "C0017658#ent", "<e2>", "may", "be", "due", "partly", "to", "a", "failure", "to", "mobilise", "dopamine", "in", "the", "kidney", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [8, 9]}}
{"token": ["C3541919#ent", "<e1>", "TRB3", ")", "is", "a", "C1540054#ent", "<e2>", "the", "level", "of", "which", "is", "increased", "in", "response", "to", "various", "stresses", "."], "h": {"id": "C3541919", "name": "C3541919#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1540054", "name": "C1540054#ent", "pos": [6, 7]}}
{"token": ["We", "now", "show", "that", "C1709442#ent", "<e1>", "and", "its", "binding", "factor", "C1538187#ent", "<e2>", "repress", "expression", "of", "sodium", "iodide", "symporter", "NIS", ")", "messenger", "RNA", "mRNA", ")", ",", "and", "inhibit", "iodide", "uptake", "."], "h": {"id": "C1709442", "name": "C1709442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1538187", "name": "C1538187#ent", "pos": [10, 11]}}
{"token": ["Simultaneously", ",", "hepatic", "lipid", "peroxidation", "C1416903#ent", "<e1>", ")", "and", "the", "activities", "of", "the", "antioxidant", "enzymes", "viz", "C0669516#ent", "<e2>", "SOD", ")", "and", "catalase", "(", "CAT", ")", "were", "examined", "."], "h": {"id": "C1416903", "name": "C1416903#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [16, 17]}}
{"token": ["We", "studied", "whether", "lead", "exposure", "increased", "the", "serum", "lipid", "peroxide", "C1416903#ent", "<e1>", ")", "level", "and", "inhibited", "C0669516#ent", "<e2>", "SOD", ")", "activity", "in", "workers", "with", "occupational", "exposure", "lead", "and", "rats", "injected", "with", "lead", "."], "h": {"id": "C1416903", "name": "C1416903#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [16, 17]}}
{"token": ["Among", "endometrioid", "carcinomas", "C1705982#ent", "<e1>", "mutations", "occur", "most", "frequently", "in", "FIGO", "grade", "2", "3", "tumors", "and", "C1705526#ent", "<e2>", "mutations", "in", "FIGO", "grade", "3", "tumors", "."], "h": {"id": "C1705982", "name": "C1705982#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [16, 17]}}
{"token": ["In", "malignant", "insulinomas", ",", "besides", "a", "strong", "immunoreaction", "for", "c-myc", "and", "TGF", "alpha", "activation", "of", "C1705982#ent", "<e1>", "and", "overexpression", "of", "C1705526#ent", "<e2>", "found", "."], "h": {"id": "C1705982", "name": "C1705982#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [20, 21]}}
{"token": ["Expression", "of", "this", "unusual", "AR", "C0597298#ent", "<e1>", "was", "inhibited", "by", "protein", "kinase", "C", "PKC", ")", "inhibitors", "such", "as", "C0054173#ent", "<e2>", "or", "H-7", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0054173", "name": "C0054173#ent", "pos": [18, 19]}}
{"token": ["The", "stimulation", "by", "C1415155#ent", "<e1>", "also", "observed", "for", "the", "light-", "or", "agonist-dependent", "phosphorylation", "of", "C1419385#ent", "<e2>", "and", "beta", "AR", "the", "mAChR", "kinase", "not", "for", "the", "light-dependent", "phosphorylation", "of", "C1419385#ent", "<e2>", "by", "rhodopsin", "kinase"], "h": {"id": "C1415155", "name": "C1415155#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [14, 15]}}
{"token": ["Our", "data", "also", "suggest", "a", "specificity", "of", "recognition", "of", "C1415155#ent", "<e1>", "which", "is", "dependent", "both", "on", "Gt", "alpha", "and", "C1419385#ent", "<e2>", "."], "h": {"id": "C1415155", "name": "C1415155#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [19, 20]}}
{"token": ["We", "measured", "plasma", "levels", "of", "tissue", "factor", "TF", ")", "and", "tissue", "factor", "pathway", "inhibitor", "C0164707#ent", "<e1>", ")", "in", "patients", "with", "thrombotic", "thrombocytopenic", "purpura", "TTP", ")", "and", "C0012739#ent", "<e2>", "DIC", ")", "to", "examine", "the", "relationship", "between", "C0164707#ent", "<e1>", "and", "vascular", "endothelial", "cell", "injury"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0164707", "name": "C0164707#ent", "pos": [14, 15]}}
{"token": ["We", "measured", "plasma", "levels", "of", "tissue", "factor", "TF", ")", "and", "tissue", "factor", "pathway", "inhibitor", "C0164707#ent", "<e1>", ")", "in", "patients", "with", "thrombotic", "thrombocytopenic", "purpura", "TTP", ")", "and", "disseminated", "intravascular", "coagulation", "C0012739#ent", "<e2>", ")", "to", "examine", "the", "relationship", "between", "C0164707#ent", "<e1>", "and", "vascular", "endothelial", "cell", "injury"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0164707", "name": "C0164707#ent", "pos": [14, 15]}}
{"token": ["We", "show", "here", "that", "the", "C1421114#ent", "<e1>", "in", "the", "absence", "of", "thyroid", "hormone", "receptor", "C3811250#ent", "<e2>", ")", "behaves", "similarly", "to", "imperfect", "EREs", ",", "which", "can", "synergize", "to", "mediate", "a", "strong", "estrogen-dependent", "activation", "transcription", "."], "h": {"id": "C1421114", "name": "C1421114#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811250", "name": "C3811250#ent", "pos": [14, 15]}}
{"token": ["C1457887#ent", "<e1>", "in", "addition", "to", "C0232492#ent", "<e2>", "discomfort", ",", "are", "nausea", ",", "vomiting", ",", "early", "satiety", "anorexia", ",", "postprandial", "abdominal", "bloating", "excessive", "repetitive", "postprandial", "belching", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0232492", "name": "C0232492#ent", "pos": [5, 6]}}
{"token": ["Microglia", "express", "several", "candidate", "C0017337#ent", "<e1>", ",", "with", "relative", "mRNA", "expression", "levels", "of", ":", "C1413484#ent", "<e2>", ">", "ClC3", ">", "I(Cln", ")", ">", "or", "=", "ClC2", ">"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413484", "name": "C1413484#ent", "pos": [14, 15]}}
{"token": ["Currently", ",", "the", "sine", "qua", "non", "for", "C1399352#ent", "<e1>", "a", "response", "to", "C0030082#ent", "<e2>", "."], "h": {"id": "C1399352", "name": "C1399352#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030082", "name": "C0030082#ent", "pos": [12, 13]}}
{"token": ["p120", "Ras", "GTPase-activating", "protein", "RasGAP", ")", "encoded", "by", "the", "C1419277#ent", "<e1>", "mice", "is", "a", "prototypical", "member", "of", "the", "C2984553#ent", "<e2>", "proteins", "involved", "in", "negative-regulation", "of", "the", "p21", "Ras", "proto-oncogene"], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2984553", "name": "C2984553#ent", "pos": [18, 19]}}
{"token": ["In", "skin", "graft", "homogenates", "under", "the", "influence", "of", "C0128329#ent", "<e1>", "rises", "the", "reduced", "under", "ischemia", "C0038615#ent", "<e2>", "activity", ",", "while", "under", "trental", "influence", "it", "does", "not", "change", "."], "h": {"id": "C0128329", "name": "C0128329#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038615", "name": "C0038615#ent", "pos": [15, 16]}}
{"token": ["Our", "data", "do", "not", "support", "the", "theory", "that", "HBV", "is", "an", "aetiological", "factor", "C0009326#ent", "<e1>", "in", "some", "cases", "of", "C0031036#ent", "<e2>"], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031036", "name": "C0031036#ent", "pos": [19, 20]}}
{"token": ["We", "suggest", "that", "this", "increased", "capillary", "permeability", "be", "the", "cause", "of", "the", "episodes", "of", "oedema", "which", "occur", "in", "patients", "with", "C0009326#ent", "<e1>", "as", "disseminated", "lupus", "erythematosus", "systemic", "sclerosis", "dermatomyositis", ",", "C0031036#ent", "<e2>", "and", "rheumatoid", "arthritis"], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0031036", "name": "C0031036#ent", "pos": [30, 31]}}
{"token": ["Most", "C0009326#ent", "<e1>", "more", "common", "in", "women", "except", "C0031036#ent", "<e2>", "but", "aging", "makes", "this", "gender", "difference", "smaller", "in", "some", "of", "the", "diseases", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031036", "name": "C0031036#ent", "pos": [8, 9]}}
{"token": ["C0002395#ent", "<e1>", "linked", "to", "one", "isotype", "of", "apo", "E", "C0052201#ent", "<e2>"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [0, 1]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0052201", "name": "C0052201#ent", "pos": [9, 10]}}
{"token": ["Pig", "plasma", "C1455838#ent", "<e1>", "PLTP", ")", "facilitates", "interconversion", "of", "both", "human", "C1858114#ent", "<e2>", "and", "pig", "HDL", "into", "HDL", "subpopulations", "of", "large", "and", "small", "particles"], "h": {"id": "C1455838", "name": "C1455838#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1858114", "name": "C1858114#ent", "pos": [11, 12]}}
{"token": ["The", "tyrosine", "kinase", "activity", "C0919477#ent", "<e1>", "was", "low", "in", "both", "thymic", "and", "C0812382#ent", "<e2>", "CD4+", "T-cell", "blasts", "before", "restimulation", "with", "TSST-1", "."], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [12, 13]}}
{"token": ["Octreotide", "is", "of", "proven", "efficacy", "in", "the", "management", "of", "patients", "with", "C0001206#ent", "<e1>", ",", "thyrotropin-secreting", "pituitary", "adenomas", "and", "certain", "gastrointestinal", "tumors", "but", "its", "effect", "in", "C0010481#ent", "<e2>", "less", "clear", "."], "h": {"id": "C0001206", "name": "C0001206#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [25, 26]}}
{"token": ["These", "results", "suggest", "the", "potential", "participation", "of", "flavine", "monooxygenase", "of", "lipooxygenase", "or", "of", "C0031179#ent", "<e1>", "having", "similar", "characteristics", "but", "not", "of", "lactoperoxidase", "or", "C1565860#ent", "<e2>", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [23, 24]}}
{"token": ["Peroxynitrite", "(", "ONOO(-", ")", ")", "activated", "the", "C0031179#ent", "<e1>", "PGHS-1", "independently", "of", "the", "C1565860#ent", "<e2>"], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [13, 14]}}
{"token": ["Structural", "perturbations", "the", "C0031179#ent", "<e1>", "MnPGHS-1", ")", "or", "at", "the", "C1565860#ent", "<e2>", "inhibitor-treated", "PGHS-1", ")", "thus", "can", "influence", "markedly", "the", "kinetics", "and", "the", "chemistry", "of", "PGHS-1", "peroxidase", "inactivation", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [10, 11]}}
{"token": ["While", "the", "C0341703#ent", "<e1>", "may", "have", "common", "functions", ",", "C1424676#ent", "<e2>", ",", "but", "not", "MRGX", "or", "MORF4", ",", "interacted", "with", "Pf1", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424676", "name": "C1424676#ent", "pos": [9, 10]}}
{"token": ["C0001047#ent", "<e1>", "and", "diclofenac", ",", "but", "less", "so", "C0011777#ent", "<e2>", ",", "are", "effective", "in", "suppressing", "wear", "debris-related", "cell", "activation", "and", "mediator", "release", "thus", "potentially", "represent", "therapeutic", "or", "preventive", "modalities", "periprosthetic", "osteolysis"], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [8, 9]}}
{"token": ["Thanks", "to", "the", "large", ",", "rigid", ",", "open", "pore", "structure", "C1706382#ent", "<e1>", ",", "the", "reaction", "rate", "K(m", ")", "of", "the", "entrapped", "C3542456#ent", "<e2>", "in", "C1706382#ent", "<e1>", "were", "comparable", "to", "those", "of", "the", "free", "enzymes", "solution", "."], "h": {"id": "C1706382", "name": "C1706382#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3542456", "name": "C3542456#ent", "pos": [21, 22]}}
{"token": ["This", "is", "the", "first", "report", "of", "BRO", "C0597979#ent", "<e1>", "M.", "lacunata", "causing", "presumed", "C0014122#ent", "<e2>", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [13, 14]}}
{"token": ["The", "in", "vivo", "activity", "of", "the", "combination", "of", "daptomycin", "and", "fosfomycin", "against", "a", "C0597979#ent", "<e1>", ",", "highly", "gentamicin-resistant", "strain", "of", "Enterococcus", "faecalis", "a", "relapse", "model", "rat", "C0014122#ent", "<e2>", "was", "studied", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [26, 27]}}
{"token": ["Nine", "Haemophilus", "species", "strains", ",", "all", "C0597979#ent", "<e1>", "negative", ",", "isolated", "from", "patients", "with", "C0014122#ent", "<e2>", "were", "tested", "in", "killing", "curve", "experiments", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [14, 15]}}
{"token": ["The", "results", "have", "been", "compared", "with", "equivalent", "data", "derived", "from", "the", "use", "of", "antiinflammatory", "agents", "e.g.", "C0004057#ent", "<e1>", ")", "and", "drugs", "of", "accepted", "'", "antirheumatoid", "activity", "(", "e.g.", "C0030817#ent", "<e2>", ")", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [28, 29]}}
{"token": ["The", "non-steroidal", "anti-inflammatory", "drugs", "phenylbutazone", ",", "salicylic", "acid", "C0004057#ent", "<e1>", ",", "sodium", "salicylate", "addition", "to", "C0030817#ent", "<e2>", "and", "dimethylsulfoxide", "caused", "dose-dependent", "inhibition", "of", "the", "cytochrome-c", "reduction", "the", "cells", "were", "stimulated", "by", "PMA", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [15, 16]}}
{"token": ["No", "scavenging", "activity", "found", "for", "C0669516#ent", "<e1>", "at", "86", "mM.", "These", "facts", "indicate", "that", "C0007404#ent", "<e2>", "have", "high", "ROO", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007404", "name": "C0007404#ent", "pos": [14, 15]}}
{"token": ["While", "the", "polydactylous", "phenotype", "of", "Alx4", "deficient", "limb", "buds", "on", "C1335824#ent", "<e1>", ",", "the", "one", "of", "C0812382#ent", "<e2>", "deficient", "limb", "buds", "completely", "independent", "of", "C1335824#ent", "<e1>", "signalling", ",", "suggesting", "that", "these", "genes", "act", "in", "parallel", "pathways"], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [16, 17]}}
{"token": ["C1335824#ent", "<e1>", "differentially", "regulates", "expression", "of", "GLI", "and", "C0812382#ent", "<e2>", "during", "limb", "development"], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [8, 9]}}
{"token": ["The", "C0042267#ent", "<e1>", "and", "associated", "treatments", "reviewed", "include", "candidiasis", "and", "C0040921#ent", "<e2>", ";", "Hemophilus", "vaginalis", "other", "bacterial", "vaginitis", "and", "Herpes", "hominis", "chlamydial", ",", "and", "atropic", "vaginitis"], "h": {"id": "C0042267", "name": "C0042267#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0040921", "name": "C0040921#ent", "pos": [10, 11]}}
{"token": ["Definite", "abnormalities", "immunity", "are", "apparent", "in", "some", "C0012634#ent", "<e1>", "the", "three", "most", "common", "are", "C0002892#ent", "<e2>", "ulcerative", "colitis", "and", "Crohn's", "disease"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002892", "name": "C0002892#ent", "pos": [14, 15]}}
{"token": ["To", "elucidate", "whether", "the", "micronucleus", "test", "be", "a", "sensitive", "test", "for", "the", "demonstration", "of", "the", "occurrence", "of", "spontaneous", "structural", "chromosomal", "aberrations", "C0012634#ent", "<e1>", "bone-marrow", "smears", "chromosome", "preparations", "studied", "from", "ten", "patients", "with", "C0002892#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0002892", "name": "C0002892#ent", "pos": [32, 33]}}
{"token": ["We", "found", "that", "several", "distal", "5", "'", "DNase", "I-hypersensitive", "sites", "(", "C1420015#ent", "<e1>", ")", "which", "function", "in", "the", "chromatin", "loop", "organization", "of", "the", "C1332772#ent", "<e2>", "characterized", "by", "strongly", "destabilized", "SIDD", "profiles", "."], "h": {"id": "C1420015", "name": "C1420015#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332772", "name": "C1332772#ent", "pos": [23, 24]}}
{"token": ["And", "unlike", "C1332163#ent", "<e1>", "tether", "and", "deliver", "substrates", "to", "C1413508#ent", "<e2>", "for", "trans-targeting", ",", "Vir", "promoted", "rapid", "degradation", "of", "Rep", "by", "C1413508#ent", "<e2>", "deleted", "for", "the", "tethering", "site", "that", "binds", "C1332163#ent", "<e1>"], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413508", "name": "C1413508#ent", "pos": [9, 10]}}
{"token": ["The", "mixed", "venous", "hypoxia", "found", "in", "28.4", "%", "of", "patients", "with", "C0041912#ent", "<e1>", "and", "in", "40", "%", "of", "patients", "with", "C0015625#ent", "<e2>", "."], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [20, 21]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "the", "C0968461#ent", "<e2>", "and", "constitutively", "expressed", "genes", "were", "each", "found", "to", "be", "present", "once", "in", "the", "haploid", "genome", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0968461", "name": "C0968461#ent", "pos": [5, 6]}}
{"token": ["We", "examined", "the", "expression", "of", "CD81", "(", "also", "known", "as", "C1420583#ent", "<e1>", ",", "or", "target", "of", "the", "C1413240#ent", "<e2>", "after", "traumatic", "spinal", "cord", "injury", "the", "rat", "."], "h": {"id": "C1420583", "name": "C1420583#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [17, 18]}}
{"token": ["The", "present", "study", "defines", "the", "expression", "pattern", "of", "C1420583#ent", "<e1>", "(", "target", "of", "the", "C1413240#ent", "<e2>", "also", "known", "as", "CD81", ")", "in", "the", "developing", "rat", "brain", "."], "h": {"id": "C1420583", "name": "C1420583#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "a", "patient", "with", "cleidocranial", "dysplasia", "C0008928#ent", "<e1>", ")", "and", "cleft", "lip", "found", "a", "new", "stop", "codon", "mutation", "C2984559#ent", "<e2>", "."], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C2984559", "name": "C2984559#ent", "pos": [19, 20]}}
{"token": ["C0008928#ent", "<e1>", "has", "been", "mapped", "to", "chromosome", "6p21", ",", "where", "C2984559#ent", "<e2>", ",", "a", "gene", "encoding", "OSF2/CBFA1", ",", "a", "transcriptional", "activator", "osteoblast", "differentiation", "has", "been", "localized", "."], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C2984559", "name": "C2984559#ent", "pos": [10, 11]}}
{"token": ["To", "test", "whether", "this", "C0017372#ent", "<e1>", "mutation", "is", "specific", "for", "the", "fcy2", "-", "20", "C0002085#ent", "<e2>", ",", "two", "double", "mutants", "constructed", "(", "Fcy2pT213I", ",", "S272L", "and", "Fcy2pS272L", ",", "N377", "G", ")", "."], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [14, 15]}}
{"token": ["The", "chromosomal", "instability", "pathway", "with", "inactivation", "of", "the", "APC/beta-catenin", "genes", "followed", "by", "activation", "of", "oncogenes", "and", "inactivation", "of", "additional", "C0017372#ent", "<e1>", "commonly", "with", "high", "frequency", "of", "C0002085#ent", "<e2>", "losses", ",", "cytogenetic", "abnormalities"], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [26, 27]}}
{"token": ["Case", "1", ",", "a", "72-year-old", "man", ",", "developed", "C0036262#ent", "<e1>", "the", "use", "of", "C0304604#ent", "<e2>", "to", "a", "misdiagnosis", "by", "an", "earlier", "physician", "."], "h": {"id": "C0036262", "name": "C0036262#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0304604", "name": "C0304604#ent", "pos": [13, 14]}}
{"token": ["C0074082#ent", "<e1>", "and", "its", "enantiomers", "were", "equipotent", "in", "the", "inhibition", "of", "C0292144#ent", "<e2>", "in", "the", "guinea", "pig", "myocardium", "."], "h": {"id": "C0074082", "name": "C0074082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0292144", "name": "C0292144#ent", "pos": [11, 12]}}
{"token": ["Graves'", "disease", "an", "autoimmune", "thyroid", "pathology", "characterized", "by", "C0020550#ent", "<e1>", ",", "thyroid", "hyperplasia", "as", "well", "as", "ophthalmopathy", "and/or", "C0033103#ent", "<e2>"], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033103", "name": "C0033103#ent", "pos": [18, 19]}}
{"token": ["Dysthyroid", "orbitopathy", "presents", "with", "the", "classical", "signs", "symptoms", "of", "C0020550#ent", "<e1>", "with", "or", "without", "C0033103#ent", "<e2>"], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033103", "name": "C0033103#ent", "pos": [14, 15]}}
{"token": ["Case", "1", "recurrence", "of", "C0020550#ent", "<e1>", "accompanied", "by", "C0033103#ent", "<e2>", "digital", "clubbing", "14", "years", "after", "thyroidectomy", "for", "Graves'", "disease"], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033103", "name": "C0033103#ent", "pos": [8, 9]}}
{"token": ["Semi-quantitative", "RT-PCR", "analysis", "of", "C1706113#ent", "<e1>", "expression", "detected", "C1620185#ent", "<e2>", "mRNA", "transcripts", "in", "the", "prostates", "of", "four", "individuals", ",", "as", "well", "as", "mRNA", "transcripts", "from", "CYP1A1", "and", "CYP1B1", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [8, 9]}}
{"token": ["This", "method", "is", "useful", "for", "rapidly", "individualizing", "C0002575#ent", "<e1>", "patients", "with", "C0006266#ent", "<e2>"], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [7, 8]}, "relation": "may_prevent", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "undertaken", "to", "evaluate", "a", "method", "of", "prospectively", "estimating", "appropriate", "C0002575#ent", "<e1>", "infusion", "rates", "in", "acutely", "ill", ",", "hospitalized", "patients", "with", "C0006266#ent", "<e2>", "."], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [12, 13]}, "relation": "may_prevent", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [23, 24]}}
{"token": ["In", "contrast", ",", "the", "decrease", "in", "systolic", "blood", "pressure", "by", "milrinone", "could", "be", "prevented", "by", "C0043167#ent", "<e1>", "pretreatment", ",", "suggesting", "the", "involvement", "of", "a", "C0086903#ent", "<e2>"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [24, 25]}}
{"token": ["Nor", "was", "the", "inhibitory", "pathway", "of", "adenylate", "cyclase", ",", "since", "C0043167#ent", "<e1>", "toxin", "--", "an", "inactivator", "of", "the", "C0086903#ent", "<e2>", "failed", "to", "abolish", "the", "suppressive", "effect", "of", "PRL", "on", "hCG-induced", "cAMP", "accumulation", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "the", "agonists", "of", "delta", "opioid", "receptors", "[D-Ala2]deltorphin", "II", "and", "[D-Pen(2,5)]enkephalin", ",", "displayed", "little", "or", "no", "activity", "this", "C0043167#ent", "<e1>", "toxin", "resistant", "C0086903#ent", "<e2>"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [24, 25]}}
{"token": ["in", "saline", "containing", "1", "mg/ml", "of", "antipain", ",", "leupeptin", "or", "C0055676#ent", "<e1>", "do", "not", "reinstate", "meiosis", "when", "C2757070#ent", "<e2>", "or", "ionophore", "A", "23187", "are", "added", "."], "h": {"id": "C0055676", "name": "C0055676#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [17, 18]}}
{"token": ["Studies", "in", "the", "laboratory", "and", "in", "the", "field", "have", "demonstrated", "that", "resistance", "to", "SP", "depends", "on", "non-synonymous", "point", "mutations", "the", "dihydrofolate", "reductase", "C0039667#ent", "<e1>", ")", ",", "and", "dihydropteroate", "synthase", "DHPS", ")", "C0079941#ent", "<e2>"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [31, 32]}}
{"token": ["The", "C0039667#ent", "<e1>", "was", "encoded", "by", "a", "633-bp", "C0079941#ent", "<e2>", "which", "specified", "an", "Mr24264", "protein", "."], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [8, 9]}}
{"token": ["Multiple", "hormone", "resistance", "many", "patients", "with", "C0033806#ent", "<e1>", "(", "PHP", ")", "type", "Ia", "and", "C2931404#ent", "<e2>", "AHO", ")", "is", "associated", "with", "deficient", "activity", "of", "the", "stimulatory", "guanine", "nucleotide-binding", "protein", "Gs", ")", "of", "adenylate", "cyclase"], "h": {"id": "C0033806", "name": "C0033806#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2931404", "name": "C2931404#ent", "pos": [14, 15]}}
{"token": ["Indorenate", "(", "5-methoxytryptamine-beta-methylcarboxylate", ")", "is", "a", "5-HT1A", "receptor", "C2987634#ent", "<e1>", "that", "produces", "C0003364#ent", "<e2>", ",", "anxiolytic", ",", "antidepressant", "and", "anticonvulsant", "effects"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [12, 13]}}
{"token": ["Also", ",", "the", "FABF", "response", "curve", "to", "the", "full", "range", "of", "both", "C2987634#ent", "<e1>", "did", "not", "differ", "between", "C0003364#ent", "<e2>", "and", "normotensives", "by", "analysis", "of", "variance", "ANOVA", ")", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [18, 19]}}
{"token": ["By", "degrading", "C3887563#ent", "<e1>", ",", "which", "is", "a", "byproduct", "of", "S-adenosyl-L-methionine-dependent", "methylation", "reactions", "C2239469#ent", "<e2>", "SAHase", ")", "acts", "as", "a", "regulator", "of", "cellular", "methylation", "processes", "."], "h": {"id": "C3887563", "name": "C3887563#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2239469", "name": "C2239469#ent", "pos": [13, 14]}}
{"token": ["A", "35-year-old", "woman", "with", "features", "of", "C0022541#ent", "<e1>", "of", "progressive", "C0033377#ent", "<e2>", ",", "ophthalmoparesis", ",", "mitochondrial", "myopathy", "and", "pigmentary", "retinopathy", "had", "autoimmune", "polyglandular", "syndrome", "type", "11", "(", "Addison's", "disease", "autoimmune", "insulin-dependent", "diabetes", "mellitus", "Hashimoto's", "thyroiditis", "and", "primary", "ovarian", "failure", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033377", "name": "C0033377#ent", "pos": [10, 11]}}
{"token": ["C0042510#ent", "<e1>", "did", "not", "occur", "in", "the", "C0360097#ent", "<e2>", "group", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0360097", "name": "C0360097#ent", "pos": [7, 8]}}
{"token": ["However", ",", "no", "C0042510#ent", "<e1>", "occurred", "with", "disopyramide", "or", "C0360097#ent", "<e2>", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0360097", "name": "C0360097#ent", "pos": [9, 10]}}
{"token": ["The", "diagnosis", "should", "be", "considered", "in", "patients", "from", "endemic", "regions", "presenting", "with", "C0235025#ent", "<e1>", "or", "without", "C0037284#ent", "<e2>"], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [16, 17]}}
{"token": ["The", "authors", "report", "the", "case", "of", "a", "very", "large", "deterged", "aortic", "valve", "ring", "abscess", "detected", "at", "long-term", "after", "C1541923#ent", "<e1>", "investigation", "of", "symptomatic", "consequent", "C0003504#ent", "<e2>"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [24, 25]}}
{"token": ["This", "report", "describes", "the", "clinical", "echocardiographic", "and", "pathologic", "findings", "a", "patient", "who", "developed", "C1541923#ent", "<e1>", "in", "aneurysm", "of", "the", "non-coronary", "cusp", "C0003504#ent", "<e2>"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [21, 22]}}
{"token": ["He", "had", "a", "history", "of", "C1541923#ent", "<e1>", "resulted", "in", "severe", "C0003504#ent", "<e2>", "three-vessel", "coronary", "artery", "disease", "and", "acute", "renal", "failure", "hemodialysis", "."], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [10, 11]}}
{"token": ["C0154694#ent", "<e1>", "by", "stroke", ",", "head", "injury", "and", "C0007789#ent", "<e2>", "results", "in", "equinovarus", "deformity", "the", "rearfoot", "."], "h": {"id": "C0154694", "name": "C0154694#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [8, 9]}}
{"token": ["Amino", "acid", "sequence", "the", "C0041236#ent", "<e1>", "fragments", "show", "some", "homology", "with", "C0002003#ent", "<e2>"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002003", "name": "C0002003#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "report", "that", "the", "appearance", "of", "CLN1", "and", "C0022340#ent", "<e1>", "RNAs", "depends", "on", "an", "active", "CDC28", "kinase", "is", "stimulated", "by", "C1413495#ent", "<e2>", "activity", "."], "h": {"id": "C0022340", "name": "C0022340#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413495", "name": "C1413495#ent", "pos": [21, 22]}}
{"token": ["The", "C0022340#ent", "<e1>", "been", "excluded", "from", "the", "CLN1", ",", "C1413495#ent", "<e2>", "and", "CLN5", "loci", "."], "h": {"id": "C0022340", "name": "C0022340#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413495", "name": "C1413495#ent", "pos": [9, 10]}}
{"token": ["C0108555#ent", "<e1>", "formerly", "casein", "kinase", "II", "is", "a", "highly", "conserved", "C0072402#ent", "<e2>", "in", "eukaryotic", "organisms"], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [10, 11]}}
{"token": ["C0108555#ent", "<e1>", "a", "ubiquitous", "C0072402#ent", "<e2>", "utilizes", "acidic", "amino", "acid", "residues", "recognition", "determinants", "its", "substrates", ",", "the", "motif", "-S/T-X-X-D/E-", "being", "particularly", "important", "."], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [4, 5]}}
{"token": ["When", "subjected", "to", "sodium", "dodecyl", "sulfate-polyacrylamide", "gel", "electrophoresis", "the", "presence", "of", "C0171406#ent", "<e1>", "the", "purified", "C0027307#ent", "<e2>", "preparation", "was", "found", "to", "co-migrate", "with", "the", "Mr", "=", "130,000", "(", "130", "K", ")", "subunit", "of", "the", "NADH-CoQ", "reductase"], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027307", "name": "C0027307#ent", "pos": [15, 16]}}
{"token": ["Repeated", "alcohol", "administration", "alters", "nucleus", "accumbens", "NAC", ")", "basal", "C0017789#ent", "<e1>", "content", "and", "sensitizes", "the", "capacity", "of", "C0001975#ent", "<e2>", "to", "increase", "NAC", "extracellular", "C0017789#ent", "<e1>", "levels", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [17, 18]}}
{"token": ["Increases", "in", "taurine", "levels", "but", "not", "of", "C0017789#ent", "<e1>", "or", "GABA", "were", "found", "after", "acute", "injection", "of", "C0001975#ent", "<e2>", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [17, 18]}}
{"token": ["The", "dopamine", ",", "C0017789#ent", "<e1>", "and", "GABA", "systems", "are", "known", "to", "mediate", "the", "effects", "of", "C0001975#ent", "<e2>", "on", "the", "movement", "disorders", "though", "their", "exact", "roles", "are", "not", "clear", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [15, 16]}}
{"token": ["For", "some", "patients", ",", "the", "complaint", "reflects", "a", "C1951340#ent", "<e1>", "independent", "of", "the", "underlying", "disease", ",", "such", "as", "myofascial", "pain", "C0158252#ent", "<e2>", "or", "osteoporosis", "."], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0158252", "name": "C0158252#ent", "pos": [20, 21]}}
{"token": ["Randomized", "phase", "III", "studies", "this", "year", "prove", "that", "docetaxel", "is", "superior", "both", "to", "best", "supportive", "care", "C3537460#ent", "<e1>", ")", "and", "to", "a", "standard", "regimen", "vinorelbine", "or", "C0020823#ent", "<e2>", "as", "second-line", "therapy", "advanced", "non", "--", "small", "cell", "lung", "cancer"], "h": {"id": "C3537460", "name": "C3537460#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [26, 27]}}
{"token": ["p190RhoGEF", "overexpression", "enhances", "RhoA", "activation", "and", "FA", "formation", "in", "MEFs", "dependent", "on", "C1704657#ent", "<e1>", "binding", "and", "associated", "with", "C2935655#ent", "<e2>", "recruitment", "and", "tyrosine", "phosphorylation"], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2935655", "name": "C2935655#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "report", "that", "C1704657#ent", "<e1>", "interacts", "with", "C2935655#ent", "<e2>", ",", "a", "RhoA-specific", "GDP/GTP", "exchange", "factor", ",", "in", "neuronal", "cells", "in", "brain", "tissue", "extracts", "by", "co-immunoprecipitation", "and", "co-localization", "analyses", "."], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2935655", "name": "C2935655#ent", "pos": [9, 10]}}
{"token": ["Repression", "of", "C3541394#ent", "<e1>", "involved", "in", "lipid", "oxidation", "acyl-CoA", "dehydrogenase", "medium", "chain", "C3658273#ent", "<e2>", "very", "long-chain", "acyl-CoA", "synthetase", "were", "associated", "with", "microvesicular", "lipidosis"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3658273", "name": "C3658273#ent", "pos": [12, 13]}}
{"token": ["The", "goal", "of", "this", "study", "was", "to", "evaluate", "the", "safety", "and", "efficacy", "of", "C1135662#ent", "<e1>", "rhDNase", ")", "in", "hospitalized", "patients", "with", "C0010674#ent", "<e2>", "CF", ")", "experiencing", "acute", "pulmonary", "exacerbations", "."], "h": {"id": "C1135662", "name": "C1135662#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [21, 22]}}
{"token": ["Deoxyribonuclease", "(", "C1135662#ent", "<e1>", ")", "has", "been", "shown", "to", "improve", "lung", "function", "patients", "with", "C0010674#ent", "<e2>", "may", "also", "have", "a", "positive", "effect", "inflammation", "."], "h": {"id": "C1135662", "name": "C1135662#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [14, 15]}}
{"token": ["C1419039#ent", "<e1>", "was", "also", "synthesized", "in", "response", "to", "12-O-tetradecanoylphorbol-13-acetate", "C0256103#ent", "<e2>", ")", "."], "h": {"id": "C1419039", "name": "C1419039#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [9, 10]}}
{"token": ["The", "aryl", "groups", "these", "tricyclic", "pyrone", "(", "C3541334#ent", "<e1>", ")", "analogs", "are", "either", "3", ",", "4-dimethoxyphenyl", "in", "C1539748#ent", "<e2>", "and", "H15", "or", "3-pyridyl", "in", "H10", "and", "H14", "."], "h": {"id": "C3541334", "name": "C3541334#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539748", "name": "C1539748#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "efficacy", "of", "a", "novel", "non", "opioid", "analgesic", "C0916802#ent", "<e1>", ",", "to", "reduce", "C2936719#ent", "<e2>", "associated", "with", "streptozotocin", "(STZ)-induced", "diabetes", ",", "in", "the", "rat", "."], "h": {"id": "C0916802", "name": "C0916802#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2936719", "name": "C2936719#ent", "pos": [19, 20]}}
{"token": ["Its", "capacity", "to", "express", "the", "C1334435#ent", "<e1>", "in", "this", "in", "vitro", "C1334043#ent", "<e2>", "monitored", "and", "showed", "high", "expression", "levels", "."], "h": {"id": "C1334435", "name": "C1334435#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}}
{"token": ["Impaired", "tube", "formation", "cell", "proliferation", "induced", "by", "inactivation", "of", "COX-1", "were", "rescued", "by", "the", "treatment", "with", "C0079594#ent", "<e1>", "or", "the", "selective", "peroxisome", "proliferator-activated", "receptor", "(PPAR)delta", "agonist", "C0966149#ent", "<e2>", "but", "not", "by", "the", "selective", "PGI(2)", "receptor", "cicaprost", "."], "h": {"id": "C0079594", "name": "C0079594#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0966149", "name": "C0966149#ent", "pos": [26, 27]}}
{"token": ["Delipidated", "fatty", "acid-binding", "protein", "rapidly", "digested", "by", "Achromobacter", "lysyl", "endopeptidase", ",", "C0008742#ent", "<e1>", "and", "Staphylococcal", "V8", "protease", ",", "while", "protein", "recombined", "C0028928#ent", "<e2>", "strongly", "refractory", "to", "proteolysis", "."], "h": {"id": "C0008742", "name": "C0008742#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [21, 22]}}
{"token": ["Severity", "of", "C0011168#ent", "<e1>", "was", "compared", "between", "the", "first", "and", "last", "C0221060#ent", "<e2>", "study", "to", "determine", "whether", "the", "swallowing", "dysfunction", "returned", "to", "normal", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0221060", "name": "C0221060#ent", "pos": [11, 12]}}
{"token": ["Microscopically", ",", "C0427055#ent", "<e1>", "of", "the", "aorta", "was", "due", "to", "C0392775#ent", "<e2>"], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0392775", "name": "C0392775#ent", "pos": [10, 11]}}
{"token": ["However", ",", "there", "is", "increasing", "interest", "in", "nonmotor", "C3160718#ent", "<e1>", "features", "such", "as", "hyposmia", ",", "C0037317#ent", "<e2>", "dementia", ",", "depression", ",", "and", "psychoses", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0037317", "name": "C0037317#ent", "pos": [15, 16]}}
{"token": ["To", "estimate", "the", "risk", "of", "C0030567#ent", "<e1>", "PD", ")", "in", "individuals", "with", "mutations", "in", "the", "C2983548#ent", "<e2>"], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C2983548", "name": "C2983548#ent", "pos": [15, 16]}}
{"token": ["His", "siblings", "who", "developed", "C0030567#ent", "<e1>", "showed", "typical", "clinical", "features", "of", "C2983548#ent", "<e2>", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C2983548", "name": "C2983548#ent", "pos": [11, 12]}}
{"token": ["The", "results", "suggest", ",", "rather", ",", "that", "the", "ratio", "of", "the", "copy", "numbers", "the", "two", "C1417679#ent", "<e1>", "is", "critical", "for", "the", "function", "of", "the", "C1707617#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1707617", "name": "C1707617#ent", "pos": [24, 25]}}
{"token": ["Granulomatous", "and", "necrotizing", "nocardial", "pneumonia", "C0036690#ent", "<e1>", "diagnosed", ",", "suggesting", "an", "C4289590#ent", "<e2>"], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4289590", "name": "C4289590#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "facial", "flushing", "alcohol", "in", "people", "taking", "C0008287#ent", "<e1>", "is", "related", "to", "C0011860#ent", "<e2>", "especially", "when", "there", "is", "a", "strong", "family", "history", "diabetes", ",", "but", "not", "to", "insulin-dependent", "diabetes"], "h": {"id": "C0008287", "name": "C0008287#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [14, 15]}}
{"token": ["By", "colorimetric", "assay", "procedures", ",", "pancreas-specific", "antigen", "no", "enzyme", "activity", "such", "as", "amylase", ",", "protease", ",", "C0014894#ent", "<e1>", ",", "lipase", ",", "acid", "phosphatase", "alkaline", "phosphatase", "peroxidase", "deoxyribonuclease", "or", "C0035542#ent", "<e2>", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [16, 17]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [28, 29]}}
{"token": ["We", "conducted", "a", "descriptive", "study", "9", "cases", "of", "C0276434#ent", "<e1>", "diagnosed", "in", "patients", "with", "C3854222#ent", "<e2>", "HIV", ")", "."], "h": {"id": "C0276434", "name": "C0276434#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [14, 15]}}
{"token": ["A", "four", "year", "old", "boy", "with", "C0038395#ent", "<e1>", "at", "Al-Nahdha", "Hospital", ",", "Muscat", ",", "Oman", ",", "with", "C0040425#ent", "<e2>", "bilateral", "cervical", "lymphadenitis"], "h": {"id": "C0038395", "name": "C0038395#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0040425", "name": "C0040425#ent", "pos": [17, 18]}}
{"token": ["Etiolated", ",", "intact", "rice", "seedlings", "are", "attached", "to", "glass", "slides", "transfected", "biolistically", "with", "C1420760#ent", "<e1>", "fused", "to", "yellow-fluorescent", "protein", "to", "visualize", "C1334752#ent", "<e2>", "and", "either", "treated", "with", "auxin", "or", "irradiated", "."], "h": {"id": "C1420760", "name": "C1420760#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334752", "name": "C1334752#ent", "pos": [21, 22]}}
{"token": ["However", ",", "the", "specific", "microbial", "salmonella-derived", "C2987634#ent", "<e1>", "responsible", "for", "activating", "C1826433#ent", "<e2>", "is", "unknown", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1826433", "name": "C1826433#ent", "pos": [11, 12]}}
{"token": ["Familial", "Mediterranean", "fever", "C1417104#ent", "<e1>", ")", "is", "a", "C0442893#ent", "<e2>", "an", "autosomal", "recessive", "inheritance", "."], "h": {"id": "C1417104", "name": "C1417104#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [8, 9]}}
{"token": ["C1417104#ent", "<e1>", "FMF", ")", "is", "a", "C0442893#ent", "<e2>", "an", "autosomal", "recessive", "inheritance", "."], "h": {"id": "C1417104", "name": "C1417104#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [6, 7]}}
{"token": ["Classical", "complexes", "bound", "ILT2", ",", "ILT4", ",", "and", "C1416854#ent", "<e1>", "transfectants", "but", "not", "C1416855#ent", "<e2>", ",", "ILT3", ",", "or", "ILT5", "."], "h": {"id": "C1416854", "name": "C1416854#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416855", "name": "C1416855#ent", "pos": [13, 14]}}
{"token": ["A", "similar", "treatment", "with", "RX821002", ",", "the", "2-methoxy", "analog", "of", "C0063327#ent", "<e1>", ",", "which", "is", "a", "highly", "selective", "C0304513#ent", "<e2>", "did", "not", "increase", "the", "density", "of", "brain", "imidazoline", "receptors"], "h": {"id": "C0063327", "name": "C0063327#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0304513", "name": "C0304513#ent", "pos": [18, 19]}}
{"token": ["Studies", "with", "C0063327#ent", "<e1>", "(", "IDA", ")", ",", "a", "specific", "C0304513#ent", "<e2>", "demonstrate", "effects", "on", "feeding", "behavior", "to", "those", "observed", "with", "norepinephrine", "in", "the", "paraventricular", "nucleus", "PVN", ")", "and", "peripheral", "injection", "the", "alpha", "2", "clonidine", "."], "h": {"id": "C0063327", "name": "C0063327#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0304513", "name": "C0304513#ent", "pos": [10, 11]}}
{"token": ["C1332126#ent", "<e1>", "or", "Axil", ",", "an", "C1334043#ent", "<e2>", "plays", "an", "important", "role", "in", "the", "regulation", "of", "beta-catenin", "stability", "in", "the", "Wnt", "signaling", "pathway"], "h": {"id": "C1332126", "name": "C1332126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}}
{"token": ["The", "products", "of", "the", "two", "mammalian", "C1332126#ent", "<e1>", "Axin1", "and", "its", "C1334043#ent", "<e2>", "are", "essential", "for", "the", "degradation", "of", "beta", "catenin", "a", "component", "of", "Wnt", "signalling", "is", "frequently", "dysregulated", "in", "cancer", "cells"], "h": {"id": "C1332126", "name": "C1332126#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}}
{"token": ["Recently", ",", "a", "novel", "candidate", "gene", ",", "C0907616#ent", "<e1>", "chromosome", "19p13", "was", "shown", "to", "be", "associated", "with", "C0007570#ent", "<e2>", "the", "Dutch", "and", "Spanish", "populations", "."], "h": {"id": "C0907616", "name": "C0907616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [17, 18]}}
{"token": ["A", "genome", "wide", "linkage", "study", "identified", "the", "C0907616#ent", "<e1>", "MYO9B", ")", "as", "a", "gene", "possibly", "associated", "with", "C0007570#ent", "<e2>"], "h": {"id": "C0907616", "name": "C0907616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [17, 18]}}
{"token": ["We", "show", "here", "that", "P", "falciparum", "developed", "similarly", "in", "normal", "RBCs", "and", "in", "sickle", "trait", ",", "beta-", "and", "C0002312#ent", "<e1>", "trait", ",", "and", "C2697530#ent", "<e2>", "RBCs", "."], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [18, 19]}, "relation": "disease_has_associated_gene", "t": {"id": "C2697530", "name": "C2697530#ent", "pos": [23, 24]}}
{"token": ["We", "report", "here", "that", "C1414655#ent", "<e1>", "a", "common", "subunit", "of", "C0016384#ent", "<e2>", "(", "alpha/beta(FTase", ")", ")", "and", "GGTase", "I", "alpha/beta(GGTase", ")", ")", ",", "was", "cleaved", "by", "caspase-3", "during", "apoptosis", "."], "h": {"id": "C1414655", "name": "C1414655#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016384", "name": "C0016384#ent", "pos": [10, 11]}}
{"token": ["We", "present", "a", "novel", "method", "of", "aspirating", "a", "C0031157#ent", "<e1>", "a", "patient", "with", "severe", "C0041105#ent", "<e2>", "."], "h": {"id": "C0031157", "name": "C0031157#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041105", "name": "C0041105#ent", "pos": [14, 15]}}
{"token": ["These", "results", "implicate", "hydroxyl", "radicals", "a", "significant", "oxidizing", "species", "C0242706#ent", "<e1>", "lung", "injury", "provide", "a", "basis", "for", "understanding", "C0009325#ent", "<e2>", "deposition", "in", "the", "neonatal", "lung", "."], "h": {"id": "C0242706", "name": "C0242706#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [18, 19]}}
{"token": ["These", "data", "indicate", "that", "children", "and", "adolescents", "with", "C2609268#ent", "<e1>", "two", "distinct", "populations", "and", "that", "C0008350#ent", "<e2>", "cholecystitis", "must", "be", "considered", "as", "a", "potential", "cause", "of", "chronic", "abdominal", "pain", "otherwise", "healthy", "adolescents", "."], "h": {"id": "C2609268", "name": "C2609268#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0008350", "name": "C0008350#ent", "pos": [15, 16]}}
{"token": ["The", "association", "of", "C1566685#ent", "<e1>", "with", "RAFTK", "was", "C1418575#ent", "<e2>", "and", "was", "increased", "upon", "RAFTK", "phosphorylation", "."], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418575", "name": "C1418575#ent", "pos": [8, 9]}}
{"token": ["Some", "cases", "of", "familial", "amyotrophic", "lateral", "sclerosis", "FALS", ")", ",", "a", "C0154671#ent", "<e1>", "motor", "neurons", "is", "associated", "with", "mutation", "in", "the", "Cu", ",", "C0669516#ent", "<e2>", "SOD", ")", "gene", "SOD1", "."], "h": {"id": "C0154671", "name": "C0154671#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [23, 24]}}
{"token": ["Familial", "amyotrophic", "lateral", "sclerosis", "FALS", ")", ",", "a", "C0154671#ent", "<e1>", "motor", "neurons", "is", "associated", "with", "mutations", "in", "the", "Cu/Zn", "superoxide", "dismutase", "gene", "C0669516#ent", "<e2>", "in", "some", "affected", "families", "."], "h": {"id": "C0154671", "name": "C0154671#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [22, 23]}}
{"token": ["Familial", "amyotrophic", "lateral", "sclerosis", "FALS", ")", ",", "a", "C0154671#ent", "<e1>", "motor", "neurons", "is", "associated", "with", "mutations", "in", "the", "C0669516#ent", "<e2>", "SOD1", "in", "some", "affected", "families", "."], "h": {"id": "C0154671", "name": "C0154671#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [18, 19]}}
{"token": ["The", "peripheral", "vasopressinergic", "system", "encompasses", "the", "sites", "of", "action", "for", "C1334081#ent", "<e1>", "released", "into", "peripheral", "circulation", "e.g.", "C1412137#ent", "<e2>", "liver", ",", "kidney", ")", "from", "nerve", "terminals", "the", "posterior", "pituitary"], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [17, 18]}}
{"token": ["C1334081#ent", "<e1>", "has", "many", "other", "receptor-mediated", "deleterious", "effects", "C1412137#ent", "<e2>", "cardiomyocytes", "."], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [8, 9]}}
{"token": ["C1420815#ent", "<e1>", "binds", "BCMA", "with", "higher", "affinity", "than", "C4284230#ent", "<e2>", "."], "h": {"id": "C1420815", "name": "C1420815#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4284230", "name": "C4284230#ent", "pos": [8, 9]}}
{"token": ["Cromolyn", "seems", "to", "be", "more", "effective", "than", "C0025573#ent", "<e1>", "and", "theophylline", "for", "prevention", "of", "late", "reactions", "C0004099#ent", "<e2>"], "h": {"id": "C0025573", "name": "C0025573#ent", "pos": [7, 8]}, "relation": "may_prevent", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [16, 17]}}
{"token": ["C0025573#ent", "<e1>", "was", "effective", "in", "preventing", "C0004099#ent", "<e2>", "administered", "15", "minutes", "before", "exercise", "but", "the", "duration", "of", "this", "protective", "effect", "less", "than", "two", "hours", "in", "most", "subjects", "."], "h": {"id": "C0025573", "name": "C0025573#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [6, 7]}}
{"token": ["In", "the", "course", "of", "infection", "by", "the", "C3854222#ent", "<e1>", "HIV", ")", "typical", "changes", "of", "C0017563#ent", "<e2>", "arise", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [14, 15]}}
{"token": ["Paroxysmal", "nocturnal", "hemoglobinuria", "C3889380#ent", "<e1>", ")", "is", "a", "chronic", "hemolytic", "anemia", "unknown", "etiology", "associated", "with", "C0005681#ent", "<e2>", "variable", "acholuric", "jaundice", "and", "striking", "hemosiderinuria", ",", "all", "signs", "of", "hemolysis", "."], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005681", "name": "C0005681#ent", "pos": [15, 16]}}
{"token": ["Paroxysmal", "nocturnal", "haemoglobinuria", "C3889380#ent", "<e1>", ")", "is", "a", "rare", "acquired", "clonal", "disorder", "haematopoietic", "stem", "cells", "intravascular", "haemolysis", "C0005681#ent", "<e2>", "and", "occasionally", "severe", "venous", "thrombotic", "complications", "."], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005681", "name": "C0005681#ent", "pos": [17, 18]}}
{"token": ["Rotarod", "performance", "was", "impaired", "in", "rats", "given", "C0012010#ent", "<e1>", "and", "chlordiazepoxide", "at", "the", "same", "doses", "at", "which", "the", "C0005064#ent", "<e2>", "were", "antihyperalgesic", "."], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [7, 8]}, "relation": "has_structural_class", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [18, 19]}}
{"token": ["We", "also", "revealed", "that", "the", "T-786", "-", "->C", "variant", "is", "strongly", "associated", "with", "C0002963#ent", "<e1>", "leads", "to", "the", "reduction", "of", "the", "C0669365#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [21, 22]}}
{"token": ["A", "3-month-old", "girl", "was", "presented", "with", "a", "right-sided", "neck", "mass", "since", "birth", "and", "accompanied", "by", "homolateral", "miosis", ",", "C0005745#ent", "<e1>", "and", "enophthalmos", "(", "C0019937#ent", "<e2>", "."], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0019937", "name": "C0019937#ent", "pos": [23, 24]}}
{"token": ["The", "triad", "miosis", "C0005745#ent", "<e1>", "and", "hemifacial", "anhidrosis", "up", "the", "well-known", "C0019937#ent", "<e2>"], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019937", "name": "C0019937#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", ",", "the", "human", "C1333721#ent", "<e1>", "TFIIF", ")", ",", "a", "heteromeric", "complex", "of", "C1333721#ent", "<e1>", "and", "RAP30", "subunits", "was", "subjected", "to", "limited", "proteolysis", "with", "trypsin", "."], "h": {"id": "C1333721", "name": "C1333721#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333721", "name": "C1333721#ent", "pos": [6, 7]}}
{"token": ["Additionally", ",", "coexpressing", "wild-type", "C3811165#ent", "<e1>", "with", "C1417807#ent", "<e2>", "in", "Hela", "cells", "to", "reduced", "levels", "of", "C1417807#ent", "<e2>", "in", "the", "culture", "medium", "suggesting", "that", "C3811165#ent", "<e1>", "negatively", "impacts", "C1417807#ent", "<e2>", "processing", "and/or", "secretion", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811165", "name": "C3811165#ent", "pos": [4, 5]}}
{"token": ["We", "demonstrated", "that", "C1417807#ent", "<e1>", "is", "a", "substrate", "of", "C3811165#ent", "<e2>", "in", "an", "in", "vitro", "assay", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811165", "name": "C3811165#ent", "pos": [9, 10]}}
{"token": ["Our", "data", "suggest", "that", "mitochondria", "increase", "their", "superoxide", "production", "apoptosis", "directly", "after", "the", "quantitative", "release", "of", "soluble", "C0021699#ent", "<e1>", "demonstrate", "novel", "antioxidative", "effects", "the", "commonly", "used", "C1854396#ent", "<e2>", "z-VAD-fmk", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1854396", "name": "C1854396#ent", "pos": [26, 27]}}
{"token": ["Pseudoporphyria", ",", "a", "cutaneous", "disorder", "characterized", "by", "skin", "fragility", "vesiculation", ",", "and", "scarring", ",", "has", "been", "reported", "as", "a", "side", "effect", "C0027396#ent", "<e1>", "children", "with", "C3495559#ent", "<e2>", "JRA", ")", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [25, 26]}}
{"token": ["To", "investigate", "the", "potential", "interaction", "of", "C0027396#ent", "<e1>", "and", "methotrexate", "(", "MTX", ")", "in", "children", "with", "C3495559#ent", "<e2>", "JRA", ")", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [16, 17]}}
{"token": ["C1366463#ent", "<e1>", "is", "a", "common", "procedure", "for", "C0037933#ent", "<e2>"], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037933", "name": "C0037933#ent", "pos": [7, 8]}}
{"token": ["Pacemaker", "implantation", "may", "be", "necessary", "especially", "if", "drugs", "such", "as", "C0033216#ent", "<e1>", ",", "which", "in", "addition", "to", "controlling", "C1457887#ent", "<e2>", "aggravate", "conduction", "disorders", "are", "to", "be", "used", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [18, 19]}}
{"token": ["To", "test", "the", "hypothesis", "that", "enzymes", "conventionally", "associated", "with", "liver", "dysfunction", "aspartate", "aminotransferase", "C0001899#ent", "<e1>", "gamma-glutamyltransferase", "[", "GGT", "]", ",", "and", "alkaline", "phosphatase", "may", "predict", "C0011847#ent", "<e2>", "."], "h": {"id": "C0001899", "name": "C0001899#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [25, 26]}}
{"token": ["We", "suggest", "that", "C1412228#ent", "<e1>", "is", "a", "target", "C0079429#ent", "<e2>", "with", "feedback", "inhibition", "on", "pax2.1", ",", "eng2", ",", "or", "fgf8", "in", "specific", "brain", "areas"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}}
{"token": ["Both", "growth", "hormone-releasing", "hormone", "GRF", ")", "and", "C1412228#ent", "<e1>", "PACAP", ")", "are", "encoded", "on", "the", "same", "C0079429#ent", "<e2>", "in", "fish", ",", "but", "not", "in", "mammals", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["C0015837#ent", "<e1>", "(", "FPF", ")", "is", "a", "C0003211#ent", "<e2>", "marketed", "as", "a", "racemic", "mixture", "its", "R(-", ")", "and", "S(+", ")", "enantiomers", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [7, 8]}}
{"token": ["To", "study", "the", "antiinflammatory", "capacity", "topical", "C0015837#ent", "<e1>", "in", "comparison", "with", "other", "C0003211#ent", "<e2>", "diclofenac", "and", "flurbiprofen", ")", "in", "albino", "rabbits"], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [6, 7]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}}
{"token": ["C0015837#ent", "<e1>", "is", "a", "nonsteroidal", "anti-inflammatory", "drug", "C0003211#ent", "<e2>", ")", "of", "the", "phenylpropionic", "acid", "class", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [7, 8]}}
{"token": ["A", "reduction", "in", "cerebral", "blood", "flow", "C1428360#ent", "<e1>", ")", ",", "mimicking", "that", "seen", "during", "the", "aura", "and", "C0270697#ent", "<e2>", "migraine", ",", "is", "typically", "observed", "following", "SD", "in", "the", "rat", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [17, 18]}}
{"token": ["The", "mean", "hemispheric", "C1428360#ent", "<e1>", "decreased", "about", "7", "%", "in", "patients", "with", "C0270697#ent", "<e2>", "and", "about", "35", "%", "in", "patients", "with", "hemiparesis", "and/or", "mental", "disturbance"], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [12, 13]}}
{"token": ["Kinetic", "studies", "the", "C3813590#ent", "<e1>", "activity", "and", "the", "inhibitory", "effects", "of", "C1257966#ent", "<e2>", "on", "the", "P-form", "of", "C3813590#ent", "<e1>", "activity", "(", "using", "Hanes-Wolf", "and", "Dixon", "plots", ")", "show", "low", "Km", "and", "Ki", "values", "."], "h": {"id": "C3813590", "name": "C3813590#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1257966", "name": "C1257966#ent", "pos": [11, 12]}}
{"token": ["The", "three", "C1418445#ent", "<e1>", "variants", "had", "specific", "activities", "similar", "to", "the", "wild-type", "C0014442#ent", "<e2>", "but", "were", "two", "to", "five", "times", "less", "sensitive", "to", "fluridone", "."], "h": {"id": "C1418445", "name": "C1418445#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["The", "C1418445#ent", "<e1>", "phytoene", "desaturase", "a", "key", "C0014442#ent", "<e2>", "in", "carotenoid", "biosynthesis", "converts", "phytoene", "to", "zeta-carotene", "."], "h": {"id": "C1418445", "name": "C1418445#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["Circulating", "C1366564#ent", "<e1>", "normal", "men", "and", "patients", "with", "C0019045#ent", "<e2>", "were", "characterized", "in", "culture", "."], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019045", "name": "C0019045#ent", "pos": [8, 9]}}
{"token": ["The", "pathology", "of", "this", "axonal", "type", "of", "C0235025#ent", "<e1>", "not", "been", "characterized", "except", "in", "a", "few", "cases", "associated", "with", "C0030489#ent", "<e2>", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030489", "name": "C0030489#ent", "pos": [19, 20]}}
{"token": ["Three", "patients", "with", "C0235025#ent", "<e1>", "an", "associated", "benign", "IgG", "C0030489#ent", "<e2>", "are", "described", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030489", "name": "C0030489#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "will", "briefly", "review", "the", "pathogenesis", "and", "discuss", "treatment", "options", "of", "the", "Guillain-Barr\u00e9", "syndrome", "chronic", "inflammatory", "demyelinating", "polyneuropathy", "C0235025#ent", "<e1>", "and", "neuropathies", "associated", "with", "C0030489#ent", "<e2>", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0030489", "name": "C0030489#ent", "pos": [25, 26]}}
{"token": ["The", "results", "of", "in", "vitro", "binding", "analysis", "co-immunoprecipitation", "analysis", "COS-7", "cells", "that", "the", "Src", "homology", "SH", ")", "3", "domain", "of", "PLC-gamma1", "binds", "to", "the", "C1424869#ent", "<e1>", "the", "Phox", "homology", "PX", ")", "domain", "of", "C1720860#ent", "<e2>", "."], "h": {"id": "C1424869", "name": "C1424869#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1720860", "name": "C1720860#ent", "pos": [33, 34]}}
{"token": ["C0378018#ent", "<e1>", "a", "novel", "C0007209#ent", "<e2>", "from", "the", "Chinese", "medical", "herb", "Astragalus", "membranaceus", "Fisch", ")", "Bge", "."], "h": {"id": "C0378018", "name": "C0378018#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [4, 5]}}
{"token": ["A", "74-year-old", "man", "underwent", "irradiation", "therapy", "RT", ")", "to", "the", "prostate", "bed", "of", "C1366489#ent", "<e1>", "PSA", ")", "failure", "after", "retropubic", "radical", "prostatectomy", "C1419380#ent", "<e2>", ")", "."], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1419380", "name": "C1419380#ent", "pos": [22, 23]}}
{"token": ["To", "evaluate", "the", "association", "between", "the", "preoperative", "C1366489#ent", "<e1>", "PSA", ")", "level", "and", "the", "interval", "to", "biochemical", "progression", "radical", "retropubic", "prostatectomy", "C1419380#ent", "<e2>", ")", "for", "prostate", "cancer"], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419380", "name": "C1419380#ent", "pos": [21, 22]}}
{"token": ["This", "study", "attempts", "to", "determine", "whether", "C1366489#ent", "<e1>", "PSA", ")", "failure", "following", "radical", "retropubic", "prostatectomy", "C1419380#ent", "<e2>", ")", "affects", "patients", "'", "long-term", "overall", "survival"], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419380", "name": "C1419380#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "which", "preoperative", "and", "postoperative", "factors", "predictive", "of", "the", "time", "to", "C1366489#ent", "<e1>", "PSA", ")", "failure", "after", "radical", "retropubic", "prostatectomy", "C1419380#ent", "<e2>", ")", "for", "patients", "with", "seminal", "vesicle", "invasion", "SVI", ")", "."], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419380", "name": "C1419380#ent", "pos": [21, 22]}}
{"token": ["The", "pharmacokinetic", "and", "dynamic", "interactions", "among", "3", "C0003374#ent", "<e1>", ",", "ie", "quinine", ",", "doxycycline", "and", "C0025153#ent", "<e2>", "was", "observed", "in", "a", "26-year-old", "Thai", "male", "patient", "with", "falciparum", "malaria", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0025153", "name": "C0025153#ent", "pos": [15, 16]}}
{"token": ["In", "the", "knockout", "HsfA2", "Arabidopsis", "plants", ",", "the", "induction", "of", "26", "HsfA2", "target", "C0017337#ent", "<e1>", "was", "strongly", "reduced", "for", "up", "to", "2", "h", "under", "C1416867#ent", "<e2>", "+", "HS", "stress", "conditions", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [24, 25]}}
{"token": ["Moreover", ",", "in", "combination", "with", "a", "subthreshold", "stimulus", "with", "anti-IgM", ",", "C0031691#ent", "<e1>", "augmented", "the", "expression", "of", "C1413235#ent", "<e2>", "and", "B7.2", "in", "nai;ve", "B", "cells", "normal", "mice"], "h": {"id": "C0031691", "name": "C0031691#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413235", "name": "C1413235#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "demonstrate", "Ezh2-independent", "targeting", "of", "maternally", "provided", "polycomb", "repressive", "complex", "1", "C1418870#ent", "<e1>", ")", "components", "to", "C0082874#ent", "<e2>"], "h": {"id": "C1418870", "name": "C1418870#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0082874", "name": "C0082874#ent", "pos": [17, 18]}}
{"token": ["An", "18-year-old", "woman", "with", "thrombotic", "thrombocytopenic", "purpura", "C1268935#ent", "<e1>", ")", "had", "recurrent", "C0040034#ent", "<e2>", "due", "to", "antiplatelet", "antibodies", "associated", "with", "systemic", "lupus", "erythematosus", "SLE", ")", "."], "h": {"id": "C1268935", "name": "C1268935#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [12, 13]}}
{"token": ["The", "results", "obtained", "have", "shown", "that", "incubation", "of", "cardiac", "muscle", "homogenates", "with", "labelled", "C1705556#ent", "<e1>", "increased", "the", "content", "of", "adenosine", "through", "raising", "5'-AMP", "nucleotidase", "activity", "inhibiting", "C0001457#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [26, 27]}}
{"token": ["The", "C1705556#ent", "<e1>", "action", "was", "not", "influenced", "by", "the", "presence", "of", "either", "C0001457#ent", "<e2>", "of", "an", "C1705556#ent", "<e1>", "regenerating", "system", "whereas", "the", "AMP", "action", "was", "increased", "by", "the", "regenerating", "system"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [12, 13]}}
{"token": ["The", "decision", "to", "use", "opioid", "analgesics", "the", "management", "of", "C0150055#ent", "<e1>", "patients", "with", "C0156147#ent", "<e2>", "a", "complex", "one", "."], "h": {"id": "C0150055", "name": "C0150055#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [13, 14]}}
{"token": ["In", "addition", "to", "FSH", ",", "C0917964#ent", "<e1>", "and", "(Bu)2cAMP", "also", "increased", "C1565830#ent", "<e2>", "state", "mRNA", "in", "Sertoli", "cells", "3.8-", ",", "4.1-", ",", "and", "9.2-fold", ",", "respectively", ")", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [11, 12]}}
{"token": ["In", "membranous", "glomerulonephritis", "C0017662#ent", "<e1>", "the", "distribution", "of", "C1706331#ent", "<e2>", ",", "LN", ",", "type", "IV", "collagen", "FNR", "and", "VNR", "was", "increased", "in", "the", "thickened", "loop", "wall", "and", "VN", "deposition", "was", "also", "observed", "."], "h": {"id": "C0017662", "name": "C0017662#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [8, 9]}}
{"token": ["Only", "1", "of", "10", "patients", "with", "type", "I", "1", "of", "15", "with", "type", "III", "membrano-proliferative", "glomerulonephritis", "C0017662#ent", "<e1>", ")", "had", "elevated", "serum", "C1706331#ent", "<e2>", "."], "h": {"id": "C0017662", "name": "C0017662#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [22, 23]}}
{"token": ["C0010980#ent", "<e1>", "belongs", "to", "C0038761#ent", "<e2>", "is", "mainly", "recommended", "in", "skin", "diseases", "gathering", "of", "neutrophiles", "or", "eosinophiles", "are", "found", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0038761", "name": "C0038761#ent", "pos": [4, 5]}}
{"token": ["C0010980#ent", "<e1>", "is", "a", "C0038761#ent", "<e2>", "with", "anti-inflammatory", "properties", "therefore", "it", "may", "have", "a", "beneficial", "effect", "in", "the", "treatment", "of", "asthma", "and", "act", "as", "a", "corticosteroid-sparing", "agent", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0038761", "name": "C0038761#ent", "pos": [4, 5]}}
{"token": ["Nicergoline", "and", "other", "Ca2", "+", "antagonists", "dose-dependently", "blocked", "the", "T-type", "Ca2", "+", "channel", "with", "an", "order", "of", "potency", "nicardipine", "greater", "than", "C0028008#ent", "<e1>", "greater", "than", "C0012373#ent", "<e2>", "."], "h": {"id": "C0028008", "name": "C0028008#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0012373", "name": "C0012373#ent", "pos": [25, 26]}}
{"token": ["NADH:(acceptor)", "oxidoreductase", "C0027293#ent", "<e1>", "EC", "1.6.99.3", ")", "activity", "declined", "in", "C0023899#ent", "<e2>", "and", "intestine", ",", "but", "not", "in", "skin", "or", "brain", "."], "h": {"id": "C0027293", "name": "C0027293#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["Specific", "activities", "of", "succinate", ":", "coenzyme", "Q", "reductase", "ubiquinone", ":", "C0027293#ent", "<e1>", "cytochrome", "oxidase", "succinate", ":", "C0027293#ent", "<e1>", "succinate", "oxidase", "and", "ubiquinol", "oxidase", "been", "measured", "in", "rat", "C0023899#ent", "<e1>", "mitochondria", "in", "the", "presence", "of", "Triton", "X-100"], "h": {"id": "C0027293", "name": "C0027293#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [27, 28]}}
{"token": ["We", "found", "that", "E2", "decreases", "the", "differentiation", "into", "OC", "of", "both", "murine", "bone", "marrow", "monocytes", "and", "RAW", "264.7", "cells", ",", "a", "C0021345#ent", "<e1>", "by", "down-regulating", "the", "activation", "of", "C1367731#ent", "<e2>", "JNK1", ")", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [28, 29]}}
{"token": ["We", "found", "that", "E2", "decreases", "the", "differentiation", "into", "OC", "of", "both", "murine", "bone", "marrow", "monocytes", "and", "RAW", "264.7", "cells", ",", "a", "C0021345#ent", "<e1>", "by", "down-regulating", "the", "activation", "of", "Jun", "N-terminal", "kinase", "1", "C1367731#ent", "<e2>", ")", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [32, 33]}}
{"token": ["The", "most", "recently", "discovered", "member", "of", "this", "family", ",", "C1438155#ent", "<e1>", "LPC", ")", ",", "is", "a", "C0021699#ent", "<e2>"], "h": {"id": "C1438155", "name": "C1438155#ent", "pos": [9, 10]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [16, 17]}}
{"token": ["One", "enzyme", "induced", "by", "cancer", "chemopreventive", "agents", "AFB1", "aldehyde", "reductase", "C1332073#ent", "<e1>", ")", ",", "which", "catalyzes", "the", "NADPH-dependent", "reduction", "of", "the", "C0063555#ent", "<e2>", "to", "a", "dialcohol", "."], "h": {"id": "C1332073", "name": "C1332073#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0063555", "name": "C0063555#ent", "pos": [21, 22]}}
{"token": ["C0013604#ent", "<e1>", "induced", "in", "rats", ",", "pretreated", "with", "C0006938#ent", "<e2>", "(", "50", "mumol", "kg-1", ",", "i.p", ".", ")", ","], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [8, 9]}}
{"token": ["Histological", "examination", "the", "irradiated", "lungs", "indicated", "that", "these", "acute", "changes", "detected", "by", "CT", "were", "associated", "with", "exudative", "and", "C0013604#ent", "<e1>", "radiation", "pneumonitis", "and", "that", "C0006938#ent", "<e2>", "reduced", "the", "severity", "of", "these", "changes", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [24, 25]}}
{"token": ["To", "evaluate", "the", "cost-effectiveness", "of", "3", "treatment", "strategies", "for", "C0029408#ent", "<e1>", "(", "OA", ")", "of", "the", "knee", ":", "C0027396#ent", "<e2>", ",", "celecoxib", ",", "and", "hyaluronan", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [18, 19]}}
{"token": ["It", "was", "concluded", "that", ",", "in", "C0029408#ent", "<e1>", "and", "rheumatoid", "arthritis", "patients", ",", "once-a-day", "controlled-release", "C0027396#ent", "<e2>", "be", "substituted", "for", "standard", "C0027396#ent", "<e2>", "loss", "of", "efficacy", "or", "tolerability", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [15, 16]}}
{"token": ["In", "a", "between-patient", "single", "blind", "controlled", "trial", ",", "two", "groups", "of", "patients", "with", "C0029408#ent", "<e1>", "were", "treated", "for", "two", "weeks", "with", "either", "Fortagesic", "or", "C0027396#ent", "<e2>"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [24, 25]}}
{"token": ["Juvenile", "systemic", "sclerosis", "C2931591#ent", "<e1>", ")", "is", "a", "rare", "form", "of", "C0036421#ent", "<e2>", "also", "known", "as", "scleroderma", ")", "."], "h": {"id": "C2931591", "name": "C2931591#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [11, 12]}}
{"token": ["A", "mutant", "with", "enhanced", "affinity", "for", "both", "maltose", "and", "starch", "produced", "a", "protein", "which", "exhibited", "elevated", "rates", "of", "diffusion", "for", "longer", "C0065601#ent", "<e1>", "but", "still", "permeated", "other", "C0242209#ent", "<e2>"], "h": {"id": "C0065601", "name": "C0065601#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0242209", "name": "C0242209#ent", "pos": [27, 28]}}
{"token": ["Based", "on", "the", "results", "of", "this", "paper", ",", "the", "authors", "conclude", "that", "the", "half-life", "of", "C1420648#ent", "<e1>", "is", "approximately", "2.2-fold", "compared", "to", "that", "of", "C3812677#ent", "<e2>", "."], "h": {"id": "C1420648", "name": "C1420648#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3812677", "name": "C3812677#ent", "pos": [24, 25]}}
{"token": ["The", "inhibitory", "effect", "of", "C1420648#ent", "<e1>", "on", "ENaC", "was", "mimicked", "by", "cyclopentyladenosine", "(", "C3812677#ent", "<e2>", ")", ",", "which", "reduced", "channel", "activity", "1.1", "to", "0.55", "."], "h": {"id": "C1420648", "name": "C1420648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3812677", "name": "C3812677#ent", "pos": [13, 14]}}
{"token": ["Studies", "assessing", "the", "role", "of", "C3541396#ent", "<e1>", "supplementation", "among", "persons", "with", "HIV", ",", "C0041296#ent", "<e2>", ",", "and", "the", "common", "cold", "have", "not", "been", "conclusive", "."], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [13, 14]}}
{"token": ["Group", "C1744607#ent", "<e1>", "received", "neither", "C0812295#ent", "<e2>", "nor", "PSF", "therapy", "."], "h": {"id": "C1744607", "name": "C1744607#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812295", "name": "C0812295#ent", "pos": [5, 6]}}
{"token": ["Furthermore", ",", "GW433908", "had", "poor", "transepithelial", "flux", "and", "C0754188#ent", "<e1>", "showed", "significant", "flux", "across", "human-derived", "Caco-2", "cell", "C0872351#ent", "<e2>", "(", "a", "model", "of", "intestinal", "permeability", ")", "."], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [17, 18]}}
{"token": ["C0013547#ent", "<e1>", "is", "a", "recently", "introduced", "C0003308#ent", "<e2>", "is", "very", "closely", "related", "structurally", "to", "another", "imidazole", "derivative", "miconazole", "."], "h": {"id": "C0013547", "name": "C0013547#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [6, 7]}}
{"token": ["C0013547#ent", "<e1>", "and", "thiabendazole", "also", "showed", "good", "C0003308#ent", "<e2>"], "h": {"id": "C0013547", "name": "C0013547#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [7, 8]}}
{"token": ["The", "C1705240#ent", "<e1>", "was", "higher", ",", "however", ",", "in", "the", "C0597563#ent", "<e2>", "the", "drug-free", "suicides", "than", "in", "the", "controls", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0597563", "name": "C0597563#ent", "pos": [10, 11]}}
{"token": ["C1705240#ent", "<e1>", "values", "for", "antidepressant-treated", "suicides", "were", "significantly", "higher", "in", "parietal", "cortex", "C0597563#ent", "<e2>", "amygdala", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597563", "name": "C0597563#ent", "pos": [12, 13]}}
{"token": ["Tubulopathic", "LCs", "damage", "the", "proximal", "tubule", "C0015624#ent", "<e1>", "precipitate", "in", "the", "distal", "tubule", "the", "C0022658#ent", "<e2>"], "h": {"id": "C0015624", "name": "C0015624#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [14, 15]}}
{"token": ["The", "clearance", "of", "125I-sodium", "iothalamate", ",", "131I-sodium", "hippurate", ",", "99mTc-DMSA", ",", "and", "beta", "2-microglobulin", "determined", "in", "20", "patients", "with", "proven", "or", "suspected", "proximal", "C0015624#ent", "<e1>", "in", "18", "control", "patients", "with", "various", "C0022658#ent", "<e2>"], "h": {"id": "C0015624", "name": "C0015624#ent", "pos": [23, 24]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [31, 32]}}
{"token": ["Of", "them", ",", "C0015624#ent", "<e1>", "be", "the", "most", "important", "risk", "factor", "C0022658#ent", "<e2>"], "h": {"id": "C0015624", "name": "C0015624#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [11, 12]}}
{"token": ["In", "C0175702#ent", "<e1>", "defective", "elastin", "deposition", "is", "associated", "with", "hemizygous", "deletion", "the", "tropoelastin", "gene", "supravalvular", "aortic", "stenosis", "C0003499#ent", "<e2>", ")", "."], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0003499", "name": "C0003499#ent", "pos": [17, 18]}}
{"token": ["N-methyl-D-aspartate", "(", "NMDA", ")", "treatment", "also", "decreased", "phosphorylation", "of", "Ser(845", ")", ",", "an", "effect", "that", "was", "blocked", "by", "MK-801", ",", "an", "C3536824#ent", "<e1>", "but", "not", "by", "C0028066#ent", "<e2>", "."], "h": {"id": "C3536824", "name": "C3536824#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [26, 27]}}
{"token": ["In", "cases", "of", "anterior", "column", "failure", ",", "such", "as", "in", "C0038016#ent", "<e1>", "supplemental", "posterior", "lumbar", "interbody", "fusion", "(", "C1414833#ent", "<e2>", ")", "may", "improve", "the", "fusion", "rate", "and", "endurance", "of", "the", "construct", "."], "h": {"id": "C0038016", "name": "C0038016#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414833", "name": "C1414833#ent", "pos": [18, 19]}}
{"token": ["Vasoactive", "intestinal", "peptide", "C1705713#ent", "<e1>", ")", "is", "a", "C1334960#ent", "<e2>", "which", "exerts", "pleiotropic", "functions"], "h": {"id": "C1705713", "name": "C1705713#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334960", "name": "C1334960#ent", "pos": [8, 9]}}
{"token": ["Indications", "for", "examination", "included", "gastro-intestinal", "bleeding", "confirmation", "or", "exclusion", "of", "peptic", "ulceration", "suspected", "on", "barium", "studies", "persistent", "and", "recurrent", "vomiting", "C0000737#ent", "<e1>", "and", "the", "evaluation", "of", "C0017168#ent", "<e2>"], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [26, 27]}}
{"token": ["Heparin", ",", "and", ",", "to", "a", "lesser", "extent", ",", "heparan", "sulfate", "induced", "release", "of", "a", "58-kDa", ",", "C0021669#ent", "<e1>", "was", "subsequently", "identified", "as", "the", "C0162745#ent", "<e2>", ",", "matrix", "metalloproteinase-1"], "h": {"id": "C0021669", "name": "C0021669#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [24, 25]}}
{"token": ["Our", "overall", "impression", "is", "that", "intracarotid", "C0070165#ent", "<e1>", "causes", "less", "C0151827#ent", "<e2>", "more", "transient", "central", "nervous", "system", "toxicity", "than", "does", "intracarotid", "BCNU.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0070165", "name": "C0070165#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151827", "name": "C0151827#ent", "pos": [10, 11]}}
{"token": ["We", "have", "here", "investigated", "the", "role", "of", "endogenous", "brain-derived", "neurotrophic", "factor", "BDNF", ")", "and", "its", "receptor", "C1704842#ent", "<e1>", "in", "the", "mechanism", "of", "action", "of", "C0003290#ent", "<e2>"], "h": {"id": "C1704842", "name": "C1704842#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003290", "name": "C0003290#ent", "pos": [24, 25]}}
{"token": ["Abnormal", "water", "retention", "for", "which", "salt", "restriction", "C0012798#ent", "<e1>", "were", "added", "to", "penicillamine", "or", "C0770325#ent", "<e2>", ",", "disappeared", "in", "all", "but", "1", "of", "the", "patients", "so", "affected", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0770325", "name": "C0770325#ent", "pos": [14, 15]}}
{"token": ["Immunoprecipitation", "studies", "that", "neither", "collagen", "alone", "nor", "the", "combination", "of", "collagen", "plus", "C0917834#ent", "<e1>", "induced", "phosphorylation", "of", "the", "GPVI-regulated", "proteins", "Syk", "and", "C1705639#ent", "<e2>", "(", "Src", "homology", "2-containing", "leucocyte", "protein", "76", "kDa", ")", "."], "h": {"id": "C0917834", "name": "C0917834#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705639", "name": "C1705639#ent", "pos": [22, 23]}}
{"token": ["The", "children", "were", "either", "relaxed", "with", "C0038627#ent", "<e1>", "(", "n", "=", "26", ")", "or", "C0042435#ent", "<e2>", "(", "n", "=", "28", ")", "."], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [14, 15]}}
{"token": ["After", "the", "administration", "of", "methylprednisolone", ",", "anesthesia", "was", "induced", "with", "thiamylal", "and", "C0038627#ent", "<e1>", "maintained", "with", "nitrous", "oxide", "enflurane", ",", "fentanyl", "and", "C0042435#ent", "<e2>", "."], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [22, 23]}}
{"token": ["Twenty-seven", "patients", "received", "1", "mg.kg-1", "of", "C0038627#ent", "<e1>", ",", "followed", "by", "0.15", "mg.kg-1", "of", "C0042435#ent", "<e2>", "when", "the", "electromyographic", "response", "to", "50", "%", "of", "control", "after", "succinylcholine-induced", "neuromuscular", "blockade", "."], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [14, 15]}}
{"token": ["Apoptosis", "was", "seen", "in", "glioma", "cells", "treated", "either", "with", "nitrogen", "mustard", "EMP", "and", "expression", "of", "C1704467#ent", "<e1>", "mRNA", "was", "not", "changed", "by", "exposure", "to", "C0013227#ent", "<e2>", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [24, 25]}}
{"token": ["The", "expression", "of", "C1704467#ent", "<e1>", "and", "bax", "proteins", "significantly", "modified", "after", "incubation", "with", "the", "C0013227#ent", "<e2>", "and", "HCQ", "activity", "against", "CLL", "cells", "independently", "of", "the", "presence", "of", "IL-4", ",", "sCD40L", "and", "bone", "marrow", "stromal", "cells"], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "in", "vivo", "chronic", "treatment", "in", "vitro", "of", "imipramine", ",", "a", "C3536819#ent", "<e1>", "or", "fluoxetine", ",", "a", "selective", "C0162758#ent", "<e2>", "on", "the", "cortical", "membrane-bound", "Na+,K+-ATPase", "activity", "were", "studied", "."], "h": {"id": "C3536819", "name": "C3536819#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [20, 21]}}
{"token": ["In", "addition", "to", "the", "classical", "C3536819#ent", "<e1>", "clomipramine", ",", "a", "number", "of", "new", "selective", "C0162758#ent", "<e2>", "now", "been", "approved", "for", "the", "treatment", "of", "OCD", "."], "h": {"id": "C3536819", "name": "C3536819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [14, 15]}}
{"token": ["High", "doses", "glucocorticoids", "(", "C1522376#ent", "<e1>", ")", "are", "widely", "employed", "to", "treat", "acute", "attacks", "relapsing-remitting", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", "patients", "."], "h": {"id": "C1522376", "name": "C1522376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [17, 18]}}
{"token": ["Salivary", "proline-rich", "proteins", "C0360714#ent", "<e1>", "are", "products", "of", "C0036091#ent", "<e2>", "rapidly", "bind", "polyphenols", "-", "thought", "to", "be", "the", "main", "astringent", "compound", "such", "as", "tea", "and", "wine", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [8, 9]}}
{"token": ["Likewise", ",", "the", "24-hour", "AUC/MIC", "ratio", "is", "a", "good", "predictor", "of", "both", "bacteriological", "and", "clinical", "efficacy", "azithromycin", "in", "C0029882#ent", "<e1>", "fluoroquinolones", "in", "C0004626#ent", "<e2>"], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0004626", "name": "C0004626#ent", "pos": [22, 23]}}
{"token": ["There", "were", "536", "skin", "and", "soft", "tissue", "infections", "263", "septicaemias", ",", "135", "lower", "C0041912#ent", "<e1>", "179", "joint", "and", "bone", "infections", "83", "C0014121#ent", "<e2>", "."], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [21, 22]}}
{"token": ["This", "preliminary", "report", "suggests", "that", "C0520796#ent", "<e1>", "with", "increased", "frequency", "and", "severity", "in", "C0162429#ent", "<e2>", "compared", "with", "well-nourished", "Jamaican", "children", "."], "h": {"id": "C0520796", "name": "C0520796#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [13, 14]}}
{"token": ["Beta-blocking", "agents", "induce", "C0042373#ent", "<e1>", "to", "environmental", "temperature", "accentuation", "of", "C0007273#ent", "<e2>", "gangrene", "of", "the", "extremities", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0007273", "name": "C0007273#ent", "pos": [10, 11]}}
{"token": ["These", "electrophysiological", "studies", "that", "native", "38", "pS", "K+", "channels", "of", "the", "C1416596#ent", "<e1>", "family", "in", "cultured", "C1567075#ent", "<e2>", "neurones", "consist", "of", "both", "homomeric", "TASK-3", "and", "heteromeric", "TASK-1/TASK-3", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1567075", "name": "C1567075#ent", "pos": [16, 17]}}
{"token": ["We", "have", "investigated", "L(pro", ")", "interaction", "with", "C2826592#ent", "<e1>", "and", "its", "C0597298#ent", "<e2>", ",", "eIF4GII", "."], "h": {"id": "C2826592", "name": "C2826592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "indicated", "that", "C2936882#ent", "<e1>", "and", "testosterone", "prevented", "C0291573#ent", "<e2>", "and", "calpain-mediated", "tau", "cleavage", ",", "respectively", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "clarify", "whether", "exercise", "thallium-201", "imaging", "(", "Tl-SPECT", ")", "and", "123I-metaiodobenzylguanidine", "imaging", "MIBG", ")", "have", "prognostic", "value", "patients", "with", "C0042291#ent", "<e1>", ",", "but", "without", "significant", "C0948480#ent", "<e2>"], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0948480", "name": "C0948480#ent", "pos": [31, 32]}}
{"token": ["Four", "unusual", "cases", "of", "patients", "are", "described", "with", "severe", "C0040128#ent", "<e1>", "TED", ")", "who", "presented", "with", "primary", "hypothyroidism", "C0342554#ent", "<e2>", "TAD", ")", "."], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0342554", "name": "C0342554#ent", "pos": [18, 19]}}
{"token": ["The", "PKC", "inhibitor", "GF-109203x", ",", "the", "C0752313#ent", "<e1>", "inhibitor", "PD-98059", ",", "and", "the", "C1456380#ent", "<e2>", "SB-203580", "significantly", "reduced", "this", "contraction", "."], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [13, 14]}}
{"token": ["PD98059", ",", "a", "C0752313#ent", "<e1>", "inhibitor", ",", "and", "SB202190", ",", "a", "C1456380#ent", "<e2>", "do", "not", "abrogate", "Bcl-2", "phosphorylation", "nor", "apoptosis", "."], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [11, 12]}}
{"token": ["C1706383#ent", "<e1>", "expression", "and", "PGE2", "production", "induced", "by", "AA", "was", "blocked", "by", "a", "C0085387#ent", "<e2>", "flurbiprofen", ",", "suggesting", "that", "PGE2", "mediated", "C1706383#ent", "<e1>", "induction", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [0, 1]}}
{"token": ["In", "the", "presence", "of", "C1413043#ent", "<e1>", "+", ",", "it", "formed", "a", "complex", "with", "C2826078#ent", "<e2>", "the", "molar", "ratio", "1", "to", "1", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2826078", "name": "C2826078#ent", "pos": [13, 14]}}
{"token": ["The", "C1417162#ent", "<e1>", "P.", "falciparum", "encodes", "an", "C0007034#ent", "<e2>", "catalytic", "properties", "distinct", "of", "that", "of", "the", "human", "host", "enzymes", "."], "h": {"id": "C1417162", "name": "C1417162#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007034", "name": "C0007034#ent", "pos": [7, 8]}}
{"token": ["Small", "intestinal", "obstruction", "colonic", "dilation", "be", "the", "mode", "of", "presentation", "in", "a", "variety", "of", "C0009373#ent", "<e1>", "including", "carcinoma", ",", "C0810029#ent", "<e2>", ",", "and", "colitis", "."], "h": {"id": "C0009373", "name": "C0009373#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0810029", "name": "C0810029#ent", "pos": [19, 20]}}
{"token": ["The", "plants", "exhibit", "varying", "degrees", "of", "therapeutic", "value", "of", "which", "useful", "in", "the", "treatment", "of", "cognitive", "dysfunction", "epilepsy", ",", "C0917801#ent", "<e1>", ",", "rheumatism", ",", "gout", ",", "C0013395#ent", "<e2>", "."], "h": {"id": "C0917801", "name": "C0917801#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [26, 27]}}
{"token": ["Luteal", "tissue", "was", "cultured", "with", "C0243192#ent", "<e1>", "(", "ciglitazone", ",", "prostaglandin", "J2", "or", "an", "antagonist", "(", "C1137010#ent", "<e2>", ")", "of", "PPARgamma", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1137010", "name": "C1137010#ent", "pos": [16, 17]}}
{"token": ["Binding", "of", "[3H]retinoic", "acid", "not", "diminished", "by", "a", "200-fold", "molar", "excess", "of", "retinal", ",", "retinol", ",", "or", "C0028928#ent", "<e1>", "is", "reduced", "by", "a", "200-fold", "excess", "of", "unlabeled", "C0022265#ent", "<e2>"], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [27, 28]}}
{"token": ["Abeta(25", "-", "35", ")", "increased", "levels", "of", "intracellular", "reactive", "oxygen", "species", "C2936886#ent", "<e1>", "in", "PC12", "cells", "caused", "cell", "death", "but", "these", "toxic", "effects", "prevented", "by", "C0123091#ent", "<e2>", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0123091", "name": "C0123091#ent", "pos": [25, 26]}}
{"token": ["Biosynthesis", "of", "estrogen", "requires", "not", "only", "C1705771#ent", "<e1>", "but", "also", "other", "C3540790#ent", "<e2>", "for", "a", "steroidogenic", "pathway", "."], "h": {"id": "C1705771", "name": "C1705771#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["A", "213-bp", "region", "of", "noncoding", "DNA", "upstream", "of", "the", "ATG", "start", "codon", "of", "the", "C0007075#ent", "<e1>", "C0007072#ent", "<e2>", ")", "structural", "gene", "been", "shown", "to", "contain", "the", "C0007072#ent", "<e2>", "promoter", "."], "h": {"id": "C0007075", "name": "C0007075#ent", "pos": [14, 15]}, "relation": "structural_class_of", "t": {"id": "C0007072", "name": "C0007072#ent", "pos": [16, 17]}}
{"token": ["Pretreatment", "with", "the", "C2713509#ent", "<e1>", "wortmannin", ",", "the", "MEK-1", "inhibitor", "PD98059", "or", "the", "protein", "kinase", "C", "inhibitor", "C0119104#ent", "<e2>", "had", "no", "effect", "on", "suppressed", "G6Pase", "expression", "by", "metformin", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0119104", "name": "C0119104#ent", "pos": [17, 18]}}
{"token": ["PMA", "(", "C", "kinase", "abolished", "FSH-mediated", "(", "but", "not", "IGF-I-mediated", ")", "phosphorylation", "of", "PKB", "at", "a", "step(s", ")", "upstream", "of", "C2713509#ent", "<e1>", "and", "independent", "of", "A", "C0031727#ent", "<e2>", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [20, 21]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [26, 27]}}
{"token": ["Verapamil", "and", "C0012373#ent", "<e1>", "significantly", "augmented", "C1337098#ent", "<e2>", "while", "nifedipine", "depressed", "C1337098#ent", "<e2>", "during", "evoked", "rises", "in", "arterial", "pressure"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1337098", "name": "C1337098#ent", "pos": [6, 7]}}
{"token": ["C0003191#ent", "<e1>", "such", "as", "C0030817#ent", "<e2>", ",", "levamisole", ",", "gold", "salts", "thiopronine", "and", "captopril", ",", "are", "potential", "aliphatic", "thiols", "strong", "reducing", "properties", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [0, 1]}, "relation": "therapeutic_class_of", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [4, 5]}}
{"token": ["Traditional", "slower", "acting", "C0003191#ent", "<e1>", "such", "as", "gold", "therapy", "C0030817#ent", "<e2>", ",", "sulfasalazine", ",", "tiopronin", "and", "hydroxychloroquine", ",", "are", "usually", "poorly", "active", "in", "children", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [9, 10]}}
{"token": ["C1414562#ent", "<e1>", ",", "a", "phosphatase", "specific", "for", "the", "carboxy-terminal", "domain", "C0035680#ent", "<e2>", "RNAP", "II", ",", "was", "found", "to", "stimulate", "transcript", "elongation", "by", "RNAP", "II", "in", "vitro", "in", "vivo"], "h": {"id": "C1414562", "name": "C1414562#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [10, 11]}}
{"token": ["Among", "the", "C0268790#ent", "<e1>", "the", "small", "intestine", "two", "major", "categories", "are", "C1412000#ent", "<e2>", "occult", "gastrointestinal", "bleeding", "secondary", "to", "mucosal", "or", "muscular", "lesion"], "h": {"id": "C0268790", "name": "C0268790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412000", "name": "C1412000#ent", "pos": [11, 12]}}
{"token": ["It", "appears", "that", "all", "classical", "risk", "factors", "HBP", ",", "C0011849#ent", "<e1>", ",", "obesity", ",", "tobacco", "use", "sedentary", ",", "menopause", ",", "C0009871#ent", "<e2>", ",", "dyslipidemia", ")", "were", "found", "among", "patients", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009871", "name": "C0009871#ent", "pos": [20, 21]}}
{"token": ["Promising", "attempts", "are", "currently", "made", "to", "inhibit", "CK-dependent", "cell", "recruitment", "to", "lesion", "by", "using", "neutralizing", "antibodies", "C1564139#ent", "<e1>", "viral", "and", "synthetic", "inhibitors", "C2936804#ent", "<e2>"], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2936804", "name": "C2936804#ent", "pos": [22, 23]}}
{"token": ["We", "used", "AMPKgamma3", "mutant-overexpressing", "Tg-Prkag3(225Q", ")", "and", "AMPKgamma3-knockout", "Prkag3-/-", "mice", "to", "determine", "the", "role", "of", "the", "AMPKgamma3", "isoform", "in", "C4025182#ent", "<e1>", "metabolic", "and", "C0017362#ent", "<e2>", "skeletal", "muscle"], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017362", "name": "C0017362#ent", "pos": [23, 24]}}
{"token": ["In", "the", "baboon", ",", "acrylamide", "produces", "a", "clinical", "illness", "characterized", "by", "weakness", "and", "C0007758#ent", "<e1>", "of", "the", "limbs", ",", "weakness", "of", "bulbar", "muscles", "and", "finally", "C0426970#ent", "<e2>", "."], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0426970", "name": "C0426970#ent", "pos": [25, 26]}}
{"token": ["Although", "all", "the", "C0991617#ent", "<e1>", "that", "are", "effective", "in", "C0002895#ent", "<e2>", "similar", "HbF-inducing", "activity", "in", "beta-thalassemia", ",", "their", "use", "has", "rarely", "resulted", "in", "significant", "amelioration", "of", "the", "anemia", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [9, 10]}}
{"token": ["To", "determine", "which", "C3536840#ent", "<e1>", "C0003211#ent", "<e2>", ")", "is", "the", "most", "effective", ",", "and", "which", "C0003211#ent", "<e2>", "is", "the", "most", "toxic", "."], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [3, 4]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [5, 6]}}
{"token": ["To", "investigate", "the", "role", "of", "initial", "C3536840#ent", "<e1>", "NSAID", ")", "choice", "in", "the", "prevention", "of", "C0003211#ent", "<e2>", "based", "on", "relative", "clinical", "and", "economic", "effects"], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [6, 7]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "incidence", "and", "recurrence", "rate", "of", "endoscopic", "ulcers", "patients", "with", "rheumatic", "diseases", "RD", ")", "taking", "C3536840#ent", "<e1>", "in", "respect", "to", "factors", "of", "C0003211#ent", "<e2>", "risk", "."], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [16, 17]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [23, 24]}}
{"token": ["It", "opens", "an", "easy", "way", "to", "determine", "the", "activities", "of", "slowly", "metabolizing", "C3540790#ent", "<e1>", "such", "as", "C1414407#ent", "<e2>", ",", "which", "are", "of", "considerable", "interest", "as", "novel", "drug", "targets"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414407", "name": "C1414407#ent", "pos": [16, 17]}}
{"token": ["In", "the", "central", "and", "peripheral", "nervous", "systems", "the", "neuropeptide", "precursor", "proenkephalin", "must", "be", "endoproteolytically", "cleaved", "by", "C3540790#ent", "<e1>", "known", "as", "prohormone", "convertases", "1", "2", "(", "C1414407#ent", "<e2>", "and", "PC2", ")", "to", "generate", "opioid-active", "enkephalins", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1414407", "name": "C1414407#ent", "pos": [25, 26]}}
{"token": ["Experiments", "were", "performed", "in", "rats", "to", "examine", "the", "distal", "site", "action", "of", "C0012802#ent", "<e1>", "the", "additive", "hypocalciuric", "properties", "of", "thiazides", "and", "C0546849#ent", "<e2>", "."], "h": {"id": "C0012802", "name": "C0012802#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [21, 22]}}
{"token": ["Directed", "mutagenesis", "used", "to", "probe", "the", "functions", "of", "Tyr-470", "and", "Tyr-481", "of", "Pseudomonas", "aeruginosa", "exotoxin", "A", "C2348358#ent", "<e1>", ")", "with", "respect", "to", "cytotoxicity", ",", "ADP-ribosylation", "of", "C1414295#ent", "<e2>", "EF-2", ")", ",", "and", "NAD-glycohydrolase", "activity"], "h": {"id": "C2348358", "name": "C2348358#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1414295", "name": "C1414295#ent", "pos": [26, 27]}}
{"token": ["Pseudomonas", "aeruginosa", "the", "virulence", "factor", "C2348358#ent", "<e1>", "(", "exotoxin", "A", ",", "which", "catalyses", "an", "ADP-ribosyltransferase", "reaction", "its", "target", "protein", "C1414295#ent", "<e2>", "(", "eukaryotic", "elongation", "factor-2", "."], "h": {"id": "C2348358", "name": "C2348358#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414295", "name": "C1414295#ent", "pos": [19, 20]}}
{"token": ["C2697656#ent", "<e1>", "also", "significantly", "decreased", "C1414563#ent", "<e2>", "activity", "and", "protein", "mass"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414563", "name": "C1414563#ent", "pos": [5, 6]}}
{"token": ["The", "branched", "molecules", "stable", "in", "high", "salt", "C0070570#ent", "<e1>", "resistant", "to", "proteinase", "K", "but", "sensitive", "to", "C0011522#ent", "<e2>", "high", "salt", "yielding", "fragments", "of", "double-stranded", "RNA"], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [16, 17]}}
{"token": ["It", "is", "resistant", "to", "heat", ",", "detergent", ",", "C0070570#ent", "<e1>", ",", "protease", ",", "and", "C0011522#ent", "<e2>", ",", "but", "it", "is", "sensitive", "to", "alkali", "and", "ribonuclease", "."], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [14, 15]}}
{"token": ["The", "action", "of", "C0070570#ent", "<e1>", "on", "the", "products", "of", "partial", "digestion", "of", "calf", "thymus", "DNA", "C0011522#ent", "<e2>", "a", "loss", "of", "3", "-", "-5", "%", "of", "the", "material", "passing", "into", "the", "phenol", "phase"], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [15, 16]}}
{"token": ["These", "observations", "demonstrate", "that", "C1413693#ent", "<e1>", "has", "an", "immunoregulatory", "function", "addition", "to", "its", "C0033978#ent", "<e2>"], "h": {"id": "C1413693", "name": "C1413693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [13, 14]}}
{"token": ["In", "the", "rabbit", "endometrium", ",", "both", "C1455381#ent", "<e1>", "and", "J912", "induce", "partial", "C2987634#ent", "<e2>", "and", "antagonist", "effects", "."], "h": {"id": "C1455381", "name": "C1455381#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [12, 13]}}
{"token": ["Prolactinomas", "responded", "well", "to", "bromocriptine", "therapy", "some", "cases", ",", "whereas", "C0001206#ent", "<e1>", "showed", "no", "remission", "after", "C0006230#ent", "<e2>", "."], "h": {"id": "C0001206", "name": "C0001206#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [16, 17]}}
{"token": ["A", "patient", "with", "longstanding", "C0001206#ent", "<e1>", "complicated", "by", "sleep", "apnea", "treated", "with", "C0006230#ent", "<e2>", "prior", "to", "surgery", "."], "h": {"id": "C0001206", "name": "C0001206#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [12, 13]}}
{"token": ["Systematic", "immunization", "resulted", "in", "a", "sharp", "decline", "of", "diphteria", ",", "polio", ",", "C0034494#ent", "<e1>", ",", "typhoid", ",", "pertussis", "and", "C0025007#ent", "<e2>", "."], "h": {"id": "C0034494", "name": "C0034494#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0025007", "name": "C0025007#ent", "pos": [19, 20]}}
{"token": ["Lysozyme", "activity", "was", "undetectable", "in", "the", "serum", "of", "both", "C0007965#ent", "<e1>", "control", "cats", "not", "of", "use", "for", "determining", "if", "the", "C0023530#ent", "<e2>", "was", "the", "result", "of", "neutrophil", "destruction"], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [20, 21]}}
{"token": ["The", "granulocyte", "defects", "of", "C0007965#ent", "<e1>", "CHS", ")", "include", "C0023530#ent", "<e2>", ",", "characteristic", "giant", "lysosomal", "granule", "morphology", ",", "and", "functionally", "abnormal", "cell", "motility", "degranulation", ",", "and", "bacterial", "killing"], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [9, 10]}}
{"token": ["Currently", "C0011311#ent", "<e1>", "is", "endemic", "in", "all", "continents", "except", "Europe", "and", "epidemic", "dengue", "C0019104#ent", "<e2>", "DHF", ")", "occurs", "in", "Asia", ",", "the", "Americas", "and", "some", "Pacific", "islands"], "h": {"id": "C0011311", "name": "C0011311#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "SiHa-CAR", ",", "a", "stable", "transfectant", "which", "expresses", "the", "CAR", "C0017337#ent", "<e1>", "showed", "a", "highly", "increased", "susceptibility", "to", "C0001486#ent", "<e2>", "contrast", "to", "SiHa", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [19, 20]}}
{"token": ["Of", "the", "more", "than", "30", "C0017337#ent", "<e1>", "encoded", "by", "the", "C0001486#ent", "<e2>", "no", "less", "than", "six", "have", "been", "shown", "to", "encode", "proteins", "that", "have", "transcription", "regulatory", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [10, 11]}}
{"token": ["The", "results", "of", "the", "study", "suggested", "that", "C0022625#ent", "<e1>", "is", "effective", "for", "the", "treatment", "of", "canine", "C0005716#ent", "<e2>", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0005716", "name": "C0005716#ent", "pos": [16, 17]}}
{"token": ["The", "cure", "rate", "these", "patients", "suggests", "that", "C0022625#ent", "<e1>", "may", "replace", "amphotericin", "B", "the", "initial", "treatment", "of", "C0005716#ent", "<e2>", "that", "is", "not", "overwhelming", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0005716", "name": "C0005716#ent", "pos": [17, 18]}}
{"token": ["That", "hexokinase", "could", "be", "conjugated", "to", "ubiquitin", "was", "shown", "by", "the", "formation", "of", "125I-ubiquitin-hexokinase", "complexes", "in", "the", "presence", "of", "ATP", "and", "the", "C3541394#ent", "<e1>", "of", "the", "C1307637#ent", "<e2>"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1307637", "name": "C1307637#ent", "pos": [26, 27]}}
{"token": ["Overall", ",", "we", "encountered", "16", "C3273590#ent", "<e1>", "patients", "(", "from", "15", "unrelated", "families", ")", "with", "C1421582#ent", "<e2>", "mutations", "."], "h": {"id": "C3273590", "name": "C3273590#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421582", "name": "C1421582#ent", "pos": [15, 16]}}
{"token": ["Src", "family", "kinases", "Lyn", ",", "Fyn", ",", "C3853652#ent", "<e1>", ",", "and", "Blk", ")", "and", "Syk", ",", "a", "tandem", "SH2", "domain", "C0033681#ent", "<e2>", "have", "been", "demonstrated", "to", "be", "associated", "with", "antigen", "receptor", "B", "cells"], "h": {"id": "C3853652", "name": "C3853652#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [20, 21]}}
{"token": ["Patients", "with", "a", "ruptured", "supratentorial", "aneurysm", "early", "surgery", "the", "C0038525#ent", "<e1>", "treated", "postoperatively", "with", "C0028094#ent", "<e2>", "to", "prevent", "delayed", "ischaemic", "dysfunction"], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [14, 15]}}
{"token": ["Clinical", "management", "patients", "affected", "by", "C0038525#ent", "<e1>", "been", "modified", "by", "the", "use", "of", "C0028094#ent", "<e2>", "."], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [13, 14]}}
{"token": ["Oral", "administration", "subcutaneous", "deposition", "C0535928#ent", "<e1>", "or", "YM022", "reduced", "the", "C0019605#ent", "<e2>", "activity", "."], "h": {"id": "C0535928", "name": "C0535928#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019605", "name": "C0019605#ent", "pos": [10, 11]}}
{"token": ["A", "single", "oral", "dose", "of", "C0535928#ent", "<e1>", "or", "YM022", "inhibited", "the", "C0019605#ent", "<e2>", "activity", "for", "2", "-", "3", "days", "."], "h": {"id": "C0535928", "name": "C0535928#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019605", "name": "C0019605#ent", "pos": [11, 12]}}
{"token": ["Prostaglandin", "H", "synthase", "C1335271#ent", "<e1>", ")", "is", "a", "heme", "protein", "catalyzes", "both", "the", "C0033551#ent", "<e2>", "and", "peroxidase", "reactions", "needed", "to", "produce", "prostaglandins", "G2", "H2", "from", "arachidonic", "acid"], "h": {"id": "C1335271", "name": "C1335271#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [13, 14]}}
{"token": ["These", "data", "imply", "that", "the", "ferryl-oxo", "intermediates", "of", "peroxidase", "catalysis", ",", "but", "not", "the", "Fe(III)/Fe(II", ")", "couple", "of", "C1335271#ent", "<e1>", ",", "are", "essential", "for", "C0033551#ent", "<e2>", "activation", "."], "h": {"id": "C1335271", "name": "C1335271#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [24, 25]}}
{"token": ["Heme", "replacement", "increased", "C1335271#ent", "<e1>", "C0033551#ent", "<e2>", "cooperativity", "and", "changed", "PGHS-2", "C0033551#ent", "<e2>", "kinetics", "from", "saturable", "to", "cooperative", "."], "h": {"id": "C1335271", "name": "C1335271#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [5, 6]}}
{"token": ["In", "a", "placebo-controlled", ",", "randomized", ",", "double-blind", ",", "cross-over", "study", "C0076126#ent", "<e1>", "(", "50", "mg/d", ")", "was", "compared", "with", "C0013954#ent", "<e2>", "(", "600", "mg/d", ")", "in", "20", "patients", "with", "motor", "urge", "incontinence"], "h": {"id": "C0076126", "name": "C0076126#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013954", "name": "C0013954#ent", "pos": [19, 20]}}
{"token": ["C0076126#ent", "<e1>", "has", "been", "compared", "with", "C0013954#ent", "<e2>", "in", "the", "treatment", "of", "20", "women", "suffering", "with", "frequency", ",", "urgency", "and", "incontinence", "in", "a", "double-blind", ",", "two-way", "cross-over", "study", "fixed", "placebo", "as", "wash-out", "."], "h": {"id": "C0076126", "name": "C0076126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013954", "name": "C0013954#ent", "pos": [6, 7]}}
{"token": ["Here", "we", "demonstrate", "that", "both", "p53", "and", "MDM2", "specifically", "recognize", "the", "C1363984#ent", "<e1>", "factor", "(TRAF)-like", "domain", "of", "C3889652#ent", "<e2>", "in", "a", "mutually", "exclusive", "manner", "."], "h": {"id": "C1363984", "name": "C1363984#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3889652", "name": "C3889652#ent", "pos": [17, 18]}}
{"token": ["In", "the", "presence", "of", "NAD(+)", "C3714920#ent", "<e1>", "poly(ADP-ribosyl)ates", "and", "evicts", "C1333214#ent", "<e2>", "(", "and", "itself", ")", "from", "chromatin", "to", "permit", "Mediator", "loading", "transcription", "independent", "of", "SET", "."], "h": {"id": "C3714920", "name": "C3714920#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333214", "name": "C1333214#ent", "pos": [10, 11]}}
{"token": ["Morphine", "reduced", "the", "potentiation", "by", "PGE2", "and", "arachidonic", "acid", "the", "bell", "shaped", "C0020429#ent", "<e1>", "was", "still", "evident", "using", "both", "C2987634#ent", "<e2>", "."], "h": {"id": "C0020429", "name": "C0020429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [19, 20]}}
{"token": ["C0146524#ent", "<e1>", "TPs", ")", ",", "the", "major", "proteins", "found", "in", "C0008546#ent", "<e2>", "of", "condensing", "spermatids", "are", "believed", "to", "be", "important", "for", "histone", "displacement", "chromatin", "condensation", "mammalian", "spermatogenesis", "."], "h": {"id": "C0146524", "name": "C0146524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [10, 11]}}
{"token": ["We", "studied", "the", "allelic", "constitution", "at", "the", "HLA", "class", "II", "DQA1", "DQB1", ",", "C1837204#ent", "<e1>", "and", "DPB1", "in", "94", "Italian", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", "patients", "and", "98", "controls", "."], "h": {"id": "C1837204", "name": "C1837204#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [22, 23]}}
{"token": ["There", "was", "a", "significant", "negative", "correlation", "between", "IC50S", "of", "C0032950#ent", "<e1>", "and", "increase-ratios", "(", "post/pre", "ratio", ")", "of", "Bmax", "after", "C0026249#ent", "<e2>", "stimulation", "(", "p", "<", "0.05", ")", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [20, 21]}}
{"token": ["In", "all", "the", "experiments", "conducted", ",", "the", "increasing", "effect", "of", "effluents", "seemed", "to", "be", "more", "pronounced", "in", "male", "C3274826#ent", "<e1>", "suggesting", "that", "C0949635#ent", "<e2>", "affected", "the", "intensity", "of", "papillomatosis", "after", "exposure", "to", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0949635", "name": "C0949635#ent", "pos": [22, 23]}}
{"token": ["Real", "Time", "PCR", "C3274826#ent", "<e1>", "demonstrated", "tandem", "duplication/multiplication", "of", "the", "C0949635#ent", "<e2>", "and", "DAZ", "genes", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0949635", "name": "C0949635#ent", "pos": [10, 11]}}
{"token": ["We", "found", "that", "M-7", "has", "the", "most", "potent", "IOP-lowering", "properties", ",", "caused", "minimal", "C2364135#ent", "<e1>", "is", "of", "interest", "as", "a", "potential", "C0597128#ent", "<e2>"], "h": {"id": "C2364135", "name": "C2364135#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0597128", "name": "C0597128#ent", "pos": [21, 22]}}
{"token": ["A", "pooled", "analysis", "performed", "of", "data", "derived", "from", "2", "prospective", ",", "randomized", ",", "double-masked", ",", "placebo-controlled", ",", "multicenter", "phase", "III", "clinical", "trials", "C0872971#ent", "<e1>", "%", "in", "patients", "with", "a", "history", "of", "C0009766#ent", "<e2>"], "h": {"id": "C0872971", "name": "C0872971#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [31, 32]}}
{"token": ["Severe", "C0036572#ent", "<e1>", "resulted", "in", "bilateral", "C0812234#ent", "<e2>", "activation", "in", "the", "cortex", "and", "hippocampus", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [6, 7]}}
{"token": ["Fibronectin", ",", "which", "had", "previously", "been", "isolated", "from", "the", "patient's", "plasma", ",", "was", "applied", "with", "a", "tuberculin", "syringe", "the", "citric", "acid", "C0029453#ent", "<e1>", "surfaces", "and", "the", "inner", "aspect", "the", "C1412362#ent", "<e2>", "."], "h": {"id": "C0029453", "name": "C0029453#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1412362", "name": "C1412362#ent", "pos": [29, 30]}}
{"token": ["Thus", ",", "in", "comparison", "to", "values", "reported", "in", "patients", "with", "normal", "renal", "function", "the", "elimination", "of", "C2828027#ent", "<e1>", "and", "total", "digoxin", "markedly", "delayed", "in", "patients", "with", "C2316810#ent", "<e2>", "which", "may", "necessitate", "prolonged", "clinical", "monitoring"], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [26, 27]}}
{"token": ["These", "C0035064#ent", "<e1>", ",", "while", "no", "more", "effective", "than", "the", "C3536819#ent", "<e2>", "TCA", ")", "drugs", ",", "are", "generally", "better", "tolerated", "than", "traditional", "medications", "used", "to", "treat", "depression", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536819", "name": "C3536819#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "intrahepatic", "glucose", "is", "an", "absolute", "requirement", "for", "hepatic", "C0029282#ent", "<e1>", "induction", "by", "isoproterenol", ",", "C0031469#ent", "<e2>", ",", "or", "glucagon", "in", "preweanling", "rats", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [17, 18]}}
{"token": ["This", "loss", "of", "appears", "to", "be", "both", "tissue-", "and", "drug-specific", ",", "as", "liver", "C0029282#ent", "<e1>", "responses", "to", "dexamethasone", ",", "dibutyryl", "cyclic", "AMP", "prostaglandin", "E-1", "heart", "C0029282#ent", "<e1>", "responses", "to", "C0031469#ent", "<e1>", "were", "not", "affected", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [29, 30]}}
{"token": ["We", "have", "shown", "previously", "that", "short-term", "nutritional", "deprivation", "a", "tissue-specific", "loss", "of", "C0029282#ent", "<e1>", "ODC", ")", "induction", "after", "isoproterenol", ",", "C0031469#ent", "<e2>", ",", "or", "glucagon", "administration", "in", "rat", "pups", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [20, 21]}}
{"token": ["Methyl-CpG", "binding", "protein", "4", "C1417052#ent", "<e1>", ")", "is", "a", "mismatch-specific", "G", "T", "and", "G", ":", "C0077845#ent", "<e2>"], "h": {"id": "C1417052", "name": "C1417052#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0077845", "name": "C0077845#ent", "pos": [15, 16]}}
{"token": ["Histologic", "examination", "the", "diagnosis", "of", "C0031038#ent", "<e1>", "showed", "findings", "according", "to", "ischemia-related", "lesions", "of", "the", "C0010709#ent", "<e2>", "."], "h": {"id": "C0031038", "name": "C0031038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [15, 16]}}
{"token": ["However", ",", "all", "swimming", "activity", "in", "reserpine-treated", "C0019575#ent", "<e1>", "was", "eliminated", "by", "the", "amine", "antagonist", "C0010620#ent", "<e2>", "."], "h": {"id": "C0019575", "name": "C0019575#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010620", "name": "C0010620#ent", "pos": [15, 16]}}
{"token": ["While", "this", "study", "showed", "favorable", "skin", "compatibility", "of", "the", "C0030946#ent", "<e1>", "containing", "lotion", ",", "the", "occurrence", "of", "allergic", "antibody", "the", "C0014442#ent", "<e2>", "was", "unacceptable", "for", "product", "commercialization", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}}
{"token": ["Adding", "increasing", "concentrations", "of", "the", "catalytically", "inactive", "C0030946#ent", "<e1>", "to", "a", "fixed", "amount", "of", "the", "wild-type", "C0014442#ent", "<e2>", "accelerated", "its", "rate", "of", "autoinactivation", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["Famotidine", ",", "a", "new", ",", "potent", ",", "long-acting", "histamine", "H2-receptor", "antagonist", "compared", "with", "cimetidine", "and", "C0034665#ent", "<e1>", "in", "9", "patients", "with", "C0043515#ent", "<e2>"], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [21, 22]}}
{"token": ["C0034665#ent", "<e1>", "has", "also", "demonstrated", "good", "results", "in", "the", "treatment", "of", "C0043515#ent", "<e2>", "in", "the", "prevention", "of", "aspiration", "pneumonitis", "given", "prior", "to", "surgery", "and", "to", "pregnant", "women", "full", "term", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [11, 12]}}
{"token": ["Whereas", "MC3R", "and", "C1417065#ent", "<e1>", "are", "expressed", "in", "all", "C1367469#ent", "<e2>", "tissues", ",", "MC4R", "seems", "to", "be", "restricted", "mainly", "to", "the", "hypothalamus", "."], "h": {"id": "C1417065", "name": "C1417065#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "the", "activity", "of", "GalT", "V", "promoter", "could", "be", "induced", "by", "C1367721#ent", "<e1>", "dominant", "active", "Ras", ",", "ERK1", ",", "JNK1", ",", "and", "C0669365#ent", "<e2>", "active", "AKT", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}}
{"token": ["C1367721#ent", "<e1>", "treatment", "caused", "consistently", "an", "enhancement", "of", "the", "C0669365#ent", "<e2>", "mRNA", "expression", "of", "transforming", "growth", "factor-alpha", "TGF-alpha", ")", ",", "but", "not", "of", "the", "EGF", "receptor", "transforming", "growth", "factor-beta"], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", "to", "other", "growth", "factor", "receptors", "the", "transmembrane", "domain", "the", "EGF", "receptor", "tolerant", "to", "a", "variety", "of", "changes", "which", "neither", "mimic", "C1367721#ent", "<e1>", "action", "by", "C0669365#ent", "<e2>", "activation", "nor", "interfere", "with", "ligand-induced", "signal", "transduction"], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [26, 27]}}
{"token": ["Phytosterolaemia", "(", "sitosterolaemia", ")", "is", "a", "very", "rare", "inherited", "sterol", "C0267971#ent", "<e1>", "characterized", "by", "tendon", "and", "C0302314#ent", "<e2>", "by", "a", "strong", "predisposition", "to", "premature", "coronary", "atherosclerosis"], "h": {"id": "C0267971", "name": "C0267971#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0302314", "name": "C0302314#ent", "pos": [16, 17]}}
{"token": ["Phytosterolaemia", "(", "sitosterolaemia", ")", "is", "a", "very", "rare", "inherited", "sterol", "C0267971#ent", "<e1>", "characterized", "by", "tendon", "and", "C0302314#ent", "<e2>", "by", "a", "predisposition", "to", "atherosclerosis", "."], "h": {"id": "C0267971", "name": "C0267971#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0302314", "name": "C0302314#ent", "pos": [16, 17]}}
{"token": ["Three", "active", "alleles", "Arg151Cys", ",", "Arg160Trp", ",", "and", "Asp294His", ")", ",", "previously", "associated", "with", "red", "hair", "doubled", "C1413531#ent", "<e1>", "risk", "for", "each", "additional", "C0002085#ent", "<e2>", "carried", "(", "odds", "ratio", ";", "95", "%", "confidence", "interval", "."], "h": {"id": "C1413531", "name": "C1413531#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [23, 24]}}
{"token": ["We", "aimed", "at", "investigating", "the", "association", "of", "age-dependent", "C1334089#ent", "<e1>", "SDS", "with", "diabetes", ",", "dyslipidemia", ",", "hypertension", ",", "and", "C0018799#ent", "<e2>", "in", "a", "large", "patient", "sample", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "to", "detect", "VZV", "in", "tissues", "of", "infected", "animals", ",", "the", "Escherichia", "coli", "C0005220#ent", "<e1>", "inserted", "into", "the", "C0042720#ent", "<e2>"], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0042720", "name": "C0042720#ent", "pos": [19, 20]}}
{"token": ["The", "patient", "was", "discharged", "with", "minimal", "C0030552#ent", "<e1>", "week", "after", "discontinuation", "of", "C0009262#ent", "<e2>", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [12, 13]}}
{"token": ["The", "results", "suggest", "that", "C1705128#ent", "<e1>", "is", "a", "C0536221#ent", "<e2>", "biological", "activity", "on", "cooperation", "between", "its", "tensin", "binding", "RhoGAP", "activities", ",", "although", "neither", "activity", "depends", "on", "the", "other", "."], "h": {"id": "C1705128", "name": "C1705128#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [8, 9]}}
{"token": ["There", "were", "no", "significant", "relations", "between", "the", "attack", "frequency", "the", "duration", "of", "C0235480#ent", "<e1>", "episodes", "and", "C1417807#ent", "<e2>", "or", "BNP", "levels", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [16, 17]}}
{"token": ["In", "66", "patients", "with", "C0235480#ent", "<e1>", "PAF", ")", "and", "without", "any", "structural", "heart", "disease", "plasma", "C1417807#ent", "<e2>", "and", "BNP", "levels", "were", "measured", "before", "and", "3", "months", "after", "successful", "PVI", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [15, 16]}}
{"token": ["injection", ")", "and", "its", "effects", "on", "the", "C3850052#ent", "<e1>", "contribute", "to", "the", "activation", "of", "this", "C0013227#ent", "<e2>", "in", "rat", "liver", "were", "then", "assessed", "."], "h": {"id": "C3850052", "name": "C3850052#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "investigated", "the", "role", "of", "C1366509#ent", "<e1>", "phosphorylation", "by", "C1418259#ent", "<e2>", "upon", "the", "process", "of", "macropinocytosis", "."], "h": {"id": "C1366509", "name": "C1366509#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418259", "name": "C1418259#ent", "pos": [10, 11]}}
{"token": ["Two", "such", "clinically", "ill", ",", "febrile", "third-trimester", "patients", ",", "one", "presenting", "with", "maternal", "C0036690#ent", "<e1>", "and", "transplacental", "fetal", "listeriosis", "and", "the", "other", "with", "C0006035#ent", "<e2>", ",", "are", "discussed", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006035", "name": "C0006035#ent", "pos": [23, 24]}}
{"token": ["Short", "use", "of", "topical", "C0010592#ent", "<e1>", "has", "been", "reported", "in", "a", "few", "cases", "of", "C1283819#ent", "<e2>"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1283819", "name": "C1283819#ent", "pos": [14, 15]}}
{"token": ["Mass", "spectral", "sequence", "analysis", "that", "Spot", "15", "a", "processed", "product", "generated", "by", "proteolytic", "cleavage", "both", "the", "C0007054#ent", "<e1>", "and", "amino", "termini", "of", "the", "34", "C0079941#ent", "<e2>"], "h": {"id": "C0007054", "name": "C0007054#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [24, 25]}}
{"token": ["Because", "these", "qualities", "may", "provide", "added", "benefit", "when", "treating", "patients", "with", "symptoms", "associated", "with", "C0878773#ent", "<e1>", "OAB", ")", "and", "urge", "incontinence", "we", "studied", "the", "effectiveness", "of", "C0772089#ent", "<e2>", "in", "treating", "these", "conditions", "."], "h": {"id": "C0878773", "name": "C0878773#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0772089", "name": "C0772089#ent", "pos": [26, 27]}}
{"token": ["Focusing", "on", "the", "clinical", "pictures", "and", "pathogenesis", "of", "human", "C0027030#ent", "<e1>", "was", "included", "to", "clarify", "the", "C0043528#ent", "<e2>", "importance", "of", "C0027030#ent", "<e1>", "in", "Egypt", "."], "h": {"id": "C0027030", "name": "C0027030#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [16, 17]}}
{"token": ["The", "C0991617#ent", "<e1>", "discussed", "are", "Mitomycin", "C", "EO9", "and", "analogues", ",", "C0764430#ent", "<e2>", "and", "the", "pyrrolo[1", ",", "2-alpha]benzimidazolequinones", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0764430", "name": "C0764430#ent", "pos": [11, 12]}}
{"token": ["The", "findings", "show", "continued", "effectiveness", "of", "erythromycin", "for", "C0275982#ent", "<e1>", "but", "an", "increasing", "trend", "of", "high", "C0008809#ent", "<e2>", "and", "tetracycline", "resistance", "."], "h": {"id": "C0275982", "name": "C0275982#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [16, 17]}}
{"token": ["Two", "of", "54", "patients", "with", "C0275982#ent", "<e1>", "a", "clinical", "relapse", "treatment", "that", "was", "associated", "with", "development", "of", "C0008809#ent", "<e2>", "resistance", "."], "h": {"id": "C0275982", "name": "C0275982#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [17, 18]}}
{"token": ["Treatment", "with", "C0041738#ent", "<e1>", "was", "started", "because", "of", "very", "severe", "poisoning", ",", "C0035078#ent", "<e2>", "optimistic", "reports", "on", "the", "\"", "new", "\"", "chelating", "agent", "propanesulphonic", "acid", "(", "C0041738#ent", "<e1>", ")", "in", "mercury", "poisoning"], "h": {"id": "C0041738", "name": "C0041738#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [12, 13]}}
{"token": ["In", "the", "absence", "of", "17", "beta-estradiol", ",", "3-hydroxytamoxifen", "gave", "rise", "to", "a", "moderate", "increase", "in", "the", "C1366500#ent", "<e1>", "levels", ",", "which", "demonstrates", "the", "partially", "estrogenic", "character", "of", "C1259921#ent", "<e2>", "."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1259921", "name": "C1259921#ent", "pos": [27, 28]}}
{"token": ["Moreover", ",", "we", "show", "that", "C1422386#ent", "<e1>", "inhibitor-induced", "apoptosis", "associated", "with", "abrogation", "of", "gamma-IFN", "production", "by", "C1423842#ent", "<e2>", "lymphocytes", "and", "with", "p53", "mRNA", "downregulation", "."], "h": {"id": "C1422386", "name": "C1422386#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [16, 17]}}
{"token": ["C1417132#ent", "<e1>", ",", "or", "the", "C0017362#ent", "<e2>", "the", "group", "A", "streptococcus", "(", "GAS", ")", "(", "Streptococcus", "pyogenes", ",", "is", "a", "transcriptional", "regulator", "virulence", "genes", "for", "colonization", "and", "immune", "evasion"], "h": {"id": "C1417132", "name": "C1417132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017362", "name": "C0017362#ent", "pos": [5, 6]}}
{"token": ["The", "frequency", "of", "C1457887#ent", "<e1>", "significantly", "improved", "in", "the", "C0072916#ent", "<e2>", "group", "(", "P", "=", "0.03", ")", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [9, 10]}}
{"token": ["Positive", "effects", "the", "rate", "of", "emptying", "of", "the", "stomach", ",", "C1457887#ent", "<e1>", "quality", "of", "life", "best", "documented", "for", "C0072916#ent", "<e2>", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [18, 19]}}
{"token": ["The", "studies", "using", "chymase", "inhibitors", "also", "shown", "the", "potential", "role", "of", "C0055673#ent", "<e1>", "in", "other", "diseases", ",", "including", "atopic", "dermatitis", "tissue", "fibrosis", "C0038013#ent", "<e2>", "a", "chymase", "inhibitor", "also", "reduced", "ischemic", "reperfusion", "injury", "the", "small", "intestine"], "h": {"id": "C0055673", "name": "C0055673#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [22, 23]}}
{"token": ["For", "this", "purpose", ",", "we", "created", "the", "C1412756#ent", "<e1>", "knockout", "mouse", "gene-targeted", "deletion", "of", "a", "portion", "of", "the", "C4082696#ent", "<e2>", "accession", "number", "M99492", ")", "."], "h": {"id": "C1412756", "name": "C1412756#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4082696", "name": "C4082696#ent", "pos": [18, 19]}}
{"token": ["Several", "components", "of", "the", "C0524620#ent", "<e1>", "with", "those", "risk", "factors", "to", "C0018784#ent", "<e2>", "SNHL", ")", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [11, 12]}}
{"token": ["Several", "components", "of", "the", "C0524620#ent", "<e1>", "with", "those", "risk", "factors", "to", "sensorineural", "hearing", "loss", "C0018784#ent", "<e2>", ")", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [14, 15]}}
{"token": ["Like", "C1453853#ent", "<e1>", "inhibition", "of", "C1259877#ent", "<e2>", "bisindolylmaleimide", "or", "calphostin", "C", "blocked", "resensitization", "."], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [5, 6]}}
{"token": ["The", "vertebrate", "enzymes", "alpha2beta2", "tetramers", ",", "whereas", "the", "C0949990#ent", "<e1>", "enzyme", "is", "an", "alphabeta", "dimer", "the", "beta", "subunit", "identical", "to", "C4284026#ent", "<e2>", "PDI", ")", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284026", "name": "C4284026#ent", "pos": [20, 21]}}
{"token": ["NO", "is", "synthesized", "by", "the", "C0907533#ent", "<e1>", "which", "converts", "the", "C2917660#ent", "<e2>", "L-arginine", "to", "citrulline", "and", "NO", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [10, 11]}}
{"token": ["The", "C0907533#ent", "<e1>", "the", "oxidation", "of", "the", "C2917660#ent", "<e2>", "L-arginine", "to", "L-citrulline", "and", "nitric", "oxide", "an", "NADPH-dependent", "reaction"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [7, 8]}}
{"token": ["Among", "these", "diseases", "were", "C0025290#ent", "<e1>", "hand-foot-and-mouth", "disease", "diarrhea", ",", "pleurodynia", ",", "myocarditis", ",", "C0019338#ent", "<e2>", ",", "and", "fevers", "."], "h": {"id": "C0025290", "name": "C0025290#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019338", "name": "C0019338#ent", "pos": [14, 15]}}
{"token": ["Positron", "emission", "tomography", "been", "shown", "to", "be", "an", "important", "tool", "for", "identifying", "viability", "within", "C0206146#ent", "<e1>", "the", "basis", "of", "enhanced", "fluorine", "18-fluorodeoxyglucose", "C1822794#ent", "<e2>", ")", "uptake", "relative", "to", "perfusion", "."], "h": {"id": "C0206146", "name": "C0206146#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1822794", "name": "C1822794#ent", "pos": [22, 23]}}
{"token": ["Phosphorylation", "and", "inactivation", "of", "rat", "muscle", "glycogen", "synthase", "casein", "kinase", "I", "casein", "kinase", "II", "glycogen", "synthase", "kinase", "5", ",", "C0206354#ent", "<e1>", "kinase", "FA", ",", "glycogen", "synthase", "kinase", "4", "phosphorylase", "b", "kinase", "and", "the", "catalytic", "subunit", "C1514550#ent", "<e2>", "similar", "to", "those", "reported", "for", "rabbit", "muscle", "synthase", "."], "h": {"id": "C0206354", "name": "C0206354#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [35, 36]}}
{"token": ["Phosphorylation", "and", "inactivation", "of", "rat", "muscle", "glycogen", "synthase", "casein", "kinase", "I", "casein", "kinase", "II", "C0206354#ent", "<e1>", ",", "glycogen", "synthase", "kinase", "3", "kinase", "FA", ",", "glycogen", "synthase", "kinase", "4", "phosphorylase", "b", "kinase", "and", "the", "catalytic", "subunit", "C1514550#ent", "<e2>", "similar", "to", "those", "reported", "for", "rabbit", "muscle", "synthase", "."], "h": {"id": "C0206354", "name": "C0206354#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [35, 36]}}
{"token": ["Phosphorylation", "and", "inactivation", "of", "rat", "muscle", "glycogen", "synthase", "casein", "kinase", "I", "casein", "kinase", "II", "glycogen", "synthase", "kinase", "5", ",", "glycogen", "synthase", "kinase", "3", "kinase", "FA", ",", "C0206354#ent", "<e1>", "phosphorylase", "b", "kinase", "and", "the", "catalytic", "subunit", "C1514550#ent", "<e2>", "similar", "to", "those", "reported", "for", "rabbit", "muscle", "synthase", "."], "h": {"id": "C0206354", "name": "C0206354#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [35, 36]}}
{"token": ["Demonstrate", "that", "bacterial", "biofilm", "in", "sinus", "mucosal", "samples", "from", "patients", "with", "eosinophilic", "mucin", "C0149516#ent", "<e1>", "EMCRS", ")", "and", "C0948780#ent", "<e2>", "AFRS", ")", "contains", "fungal", "elements", ";", "identify", "specific", "organisms", "in", "the", "biofilm", "."], "h": {"id": "C0149516", "name": "C0149516#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0948780", "name": "C0948780#ent", "pos": [18, 19]}}
{"token": ["One", "hundred", "fifty-seven", "patients", "with", "endoscopically", "verified", "benign", "C0038358#ent", "<e1>", "randomized", "in", "a", "double-blind", "fashion", "either", "C0015620#ent", "<e2>", "(", "40", "mg", "at", "bedtime", ")", "or", "placebo", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0015620", "name": "C0015620#ent", "pos": [16, 17]}}
{"token": ["FK506", ",", "an", "immunosuppressive", "drug", "shows", "C0038358#ent", "<e1>", "effects", "equivalent", "to", "C0015620#ent", "<e2>", ",", "an", "H2", "blocker", "in", "rats", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0015620", "name": "C0015620#ent", "pos": [11, 12]}}
{"token": ["Northern", "blot", "analysis", "marked", "upregulation", "in", "P1", "of", "the", "brain-specific", "protein", "phosphatase", "2A", "beta", "subunit", "PPP2R2B", ")", ",", "a", "causative", "gene", "C1858501#ent", "<e1>", "and", "the", "cerebellar", "degeneration-related", "autoantigen", "CDR34", ")", "gene", "associated", "with", "development", "of", "C0262404#ent", "<e2>"], "h": {"id": "C1858501", "name": "C1858501#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0262404", "name": "C0262404#ent", "pos": [35, 36]}}
{"token": ["Expression", "of", "C1313497#ent", "<e1>", "in", "tissues", "can", "be", "used", "as", "an", "C1413226#ent", "<e2>", "cytotoxic", "cells"], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413226", "name": "C1413226#ent", "pos": [11, 12]}}
{"token": ["Antinociception", "produced", "by", "C0057341#ent", "<e1>", "THC", ")", "and", "C0057341#ent", "<e1>", "i.v", ".", ","], "h": {"id": "C0057341", "name": "C0057341#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0057341", "name": "C0057341#ent", "pos": [3, 4]}}
{"token": ["Similarly", ",", "activation", "of", "protein", "kinase", "A", "C0033634#ent", "<e1>", "consequences", "of", "C0060916#ent", "<e2>", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0060916", "name": "C0060916#ent", "pos": [11, 12]}}
{"token": ["He", "too", "was", "subsequently", "found", "to", "be", "seropositive", "for", "C0019693#ent", "<e1>", "and", "was", "treated", "with", "stavudine", ",", "lamivudine", "and", "C0132326#ent", "<e2>", "from", "May", "2004", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [9, 10]}, "relation": "may_be_prevented_by", "t": {"id": "C0132326", "name": "C0132326#ent", "pos": [19, 20]}}
{"token": ["Two", "divergent", "transcriptional", "units", "the", "C1825842#ent", "<e1>", "and", "acuABC", "C0017337#ent", "<e2>", "were", "also", "found", "in", "this", "region", "."], "h": {"id": "C1825842", "name": "C1825842#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["The", "C1825842#ent", "<e1>", "and", "acuABC", "C0017337#ent", "<e2>", "are", "divergently", "transcribed", ",", "with", "only", "20", "bp", "separating", "the", "-35", "sequences", "of", "their", "promoters", "."], "h": {"id": "C1825842", "name": "C1825842#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}}
{"token": ["C0036637#ent", "<e1>", "and", "ACNU", "reduced", "spermidine", "and", "C0031957#ent", "<e2>", "in", "the", "corpus", "striatum", "and", "C0031957#ent", "<e2>", "in", "the", "diencephalon", ",", "but", "increased", "putrescine", "in", "the", "corpus", "striatum", "combined", "thalamus", "hypothalamus", "."], "h": {"id": "C0036637", "name": "C0036637#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [7, 8]}}
{"token": ["Leptin-deficient", "ob/ob", "mice", "are", "hyperinsulinaemic", "and", "C0020456#ent", "<e1>", ";", "however", ",", "the", "cause", "of", "C0475718#ent", "<e2>", "remains", "largely", "unknown", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0475718", "name": "C0475718#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "focus", "on", "the", "role", "of", "the", "pebble", "(", "pbl", ")", "C0079429#ent", "<e1>", "of", "Drosophila", "melanogaster", "a", "C2748553#ent", "<e2>", "that", "is", "required", "for", "cytokinesis", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2748553", "name": "C2748553#ent", "pos": [18, 19]}}
{"token": ["Dermatophytosis", ",", "candidosis", "and", "C0040262#ent", "<e1>", "for", "the", "majority", "of", "fungal", "C0037274#ent", "<e2>", "Denmark", "and", "are", "seen", "in", "8", "%", "of", "patients", "with", "dermato-venerological", "problems", "."], "h": {"id": "C0040262", "name": "C0040262#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [11, 12]}}
{"token": ["Pityriasis", "versicolor", "C0040262#ent", "<e1>", "is", "a", "common", "C0037274#ent", "<e2>", "to", "Malassezia", "usually", "affecting", "adolescents", "and", "young", "adults", "more", "frequently", "in", "the", "tropics", "."], "h": {"id": "C0040262", "name": "C0040262#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}}
{"token": ["Apart", "from", "C0040262#ent", "<e1>", "M.", "furfur", "been", "linked", "to", "several", "C0037274#ent", "<e2>", "as", "seborrheic", "dermatitis", "folliculitis", "or", "atopic", "dermatitis"], "h": {"id": "C0040262", "name": "C0040262#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [10, 11]}}
{"token": ["We", "also", "observed", "a", "blunted", "increase", "in", "C3274822#ent", "<e1>", "in", "old", "rats", "response", "to", "acute", "converting", "C0027203#ent", "<e2>", "inhibition", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}}
{"token": ["The", "kinetic", "properties", "of", "the", "C0027203#ent", "<e1>", "demonstrate", "that", "intermediate", "CdRP", "formed", "from", "C3274822#ent", "<e2>", "must", "dissociate", "from", "the", "C0027203#ent", "<e1>", "before", "it", "can", "be", "converted", "into", "InGP", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "the", "transcription", "factor", "C0812312#ent", "<e1>", "is", "not", "required", "for", "activation-induced", "C1539478#ent", "<e2>", "promoter", "activity", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [13, 14]}}
{"token": ["These", "results", "demonstrate", "the", "crucial", "roles", "for", "NF-kappaB", "and", "C0812312#ent", "<e1>", "in", "the", "regulation", "of", "C1539478#ent", "<e2>", "in", "Fas-mediated", "thymineless", "death", "of", "colon", "carcinoma", "cells"], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [15, 16]}}
{"token": ["We", "report", "that", "activation", "of", "the", "two", "transcription", "factors", "NF-kappa", "B", "C0812312#ent", "<e1>", "is", "crucially", "involved", "in", "C1539478#ent", "<e2>", "expression", "induced", "by", "etoposide", ",", "teniposide", ",", "and", "UV", "irradiation", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [17, 18]}}
{"token": ["Six", "patients", "free", "of", "peritonitis", "displayed", "low", "but", "significant", "levels", "of", "C1334122#ent", "<e1>", "(", "mean", "+", "/-", "42", "pg/ml", ")", "in", "C0031640#ent", "<e2>", ",", "while", "C1334122#ent", "<e1>", "was", "undetectable", "in", "serum", "."], "h": {"id": "C1334122", "name": "C1334122#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [21, 22]}}
{"token": ["The", "C1332727#ent", "<e1>", "the", "product", "of", "an", "C1336564#ent", "<e2>", "and", "is", "involved", "in", "three", "aspects", "of", "DNA", "metabolism", "mitotic", "DNA", "replication", "meiotic", "DNA", "recombination", "and", "replication-dependent", "DNA", "repair"], "h": {"id": "C1332727", "name": "C1332727#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1336564", "name": "C1336564#ent", "pos": [7, 8]}}
{"token": ["C-Type", "natriuretic", "peptide", "receptors", "which", "lack", "the", "C0018358#ent", "<e1>", "alter", "target", "cell", "function", "C1333649#ent", "<e2>", "inhibition", "of", "membrane", "adenylyl", "cyclase", "activity", "and", "also", "serve", "to", "clear", "circulating", "natriuretic", "peptides"], "h": {"id": "C0018358", "name": "C0018358#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333649", "name": "C1333649#ent", "pos": [13, 14]}}
{"token": ["A", "4", "1/2-year-old", "boy", "with", "acute", "myelomonocytic", "leukemia", "fever", ",", "C0023530#ent", "<e1>", ",", "and", "a", "prolonged", "C0221423#ent", "<e2>", "receiving", "maintenance", "chemotherapy"], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [16, 17]}}
{"token": ["C0023530#ent", "<e1>", ",", "T-cell", "defects", "B-cell", "defects", "and", "splenectomy", "lead", "to", "either", "specific", "C0221423#ent", "<e2>", "or", "more", "severe", "manifestations", "of", "infection", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [13, 14]}}
{"token": ["Thirteen", "(", "3.9", "%", ")", "of", "these", "patients", "experienced", "recurrent", "episodes", "of", "C1142127#ent", "<e1>", "and", "all", "of", "them", "had", "underlying", "C0029896#ent", "<e2>", "."], "h": {"id": "C1142127", "name": "C1142127#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [20, 21]}}
{"token": ["The", "C0002085#ent", "<e1>", "the", "83097", "C", ">", "T", "polymorphism", "of", "C1415813#ent", "<e2>", "showed", "a", "tendency", "of", "preferential", "transmission", "to", "probands", "with", "ADHD", "(", "chi(2)=2.699", ",", "P=0.100", ")", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415813", "name": "C1415813#ent", "pos": [10, 11]}}
{"token": ["In", "OCLs", ",", "newly", "formed", "LBC", "acquired", "C1413815#ent", "<e1>", "tartarate-resistant", "phosphatase", "TRAP", ")", ",", "lysosome-associated", "membrane", "protein-1", "Lamp-1", ")", ",", "and", "C0007427#ent", "<e2>", "and", "rapidly", "lost", "annexin", "II", "a", "time-dependent", "manner", "."], "h": {"id": "C1413815", "name": "C1413815#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [21, 22]}}
{"token": ["Benzodiazepine", "receptor", "binding", "in", "cerebrospinal", "fluid", "significantly", "higher", "in", "C0019151#ent", "<e1>", "patients", "than", "in", "controls", "(", "210", "[", "C1414863#ent", "<e2>", "50.2", "]", "vs", "40.7", "[", "7.3", "]", "oxazepam", "equivalents", "[", "ng/ml", "]", ")", "."], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [18, 19]}}
{"token": ["This", "study", "was", "performed", "by", "immunohistochemical", "reaction", "testing", "tubulin", "and", "C0010290#ent", "<e1>", "visualize", "the", "neuronal", "structure", "by", "immunohistochemical", "reaction", "testing", "astroprotein", "(", "an", "C1416925#ent", "<e2>", "to", "visualize", "reactive", "astrocytes", "."], "h": {"id": "C0010290", "name": "C0010290#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416925", "name": "C1416925#ent", "pos": [23, 24]}}
{"token": ["Pharmacoeconomic", "data", "a", "small", "study", "of", "patients", "with", "C0036572#ent", "<e1>", "a", "US", "emergency", "department", "an", "overall", "cost", "advantage", "of", "C0244656#ent", "<e2>", "over", "phenytoin", ",", "despite", "a", "considerably", "greater", "acquisition", "cost", "of", "C0244656#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0244656", "name": "C0244656#ent", "pos": [19, 20]}}
{"token": ["Benzodiazepines", "have", "become", "first-line", "drugs", "for", "treatment", "of", "C0036572#ent", "<e1>", "status", "epilepticus", "followed", "by", "C0244656#ent", "<e2>", "and", "phenobarbital", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0244656", "name": "C0244656#ent", "pos": [14, 15]}}
{"token": ["The", "NSAIDs", "and", "C1257954#ent", "<e1>", "increased", "levels", "of", "soluble", "C1705770#ent", "<e2>", "in", "the", "media", "of", "cultured", "astrocytes", "and", "neurons", ",", "perhaps", "acting", "by", "inhibition", "of", "prostaglandin", "production", "."], "h": {"id": "C1257954", "name": "C1257954#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705770", "name": "C1705770#ent", "pos": [9, 10]}}
{"token": ["C1122828#ent", "<e1>", "Nei", ")", "is", "one", "of", "three", "C3541394#ent", "<e2>", "in", "Escherichia", "coli", "are", "involved", "in", "base-excision", "repair", "oxidative", "damage", "to", "DNA", "."], "h": {"id": "C1122828", "name": "C1122828#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [8, 9]}}
{"token": ["UIC2", "reactivity", "with", "C1422070#ent", "<e1>", "was", "increased", "by", "the", "addition", "of", "several", "Pgp-transported", "compounds", "or", "ATP-depleting", "agents", ",", "and", "by", "mutational", "inactivation", "both", "C3814821#ent", "<e2>", "NBDs", ")", "of", "C1422070#ent", "<e1>", "."], "h": {"id": "C3814821", "name": "C3814821#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [3, 4]}}
{"token": ["N-Acetylglucosaminyltransferase", "III", "C1417135#ent", "<e1>", ")", "is", "a", "key", "C0014442#ent", "<e2>", "that", "inhibits", "the", "extension", "of", "N-glycans", "by", "introducing", "a", "bisecting", "N-acetylglucosamine", "residue"], "h": {"id": "C1417135", "name": "C1417135#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}}
{"token": ["Changes", "in", "the", "enzymatic", "activities", "of", "other", "glycosyltransferases", ",", "such", "as", "alpha1,3-galactosyltransferase", ",", "GnT-IV", ",", "and", "GnT-V", ",", "did", "not", "support", "cross-talk", "between", "C1417135#ent", "<e1>", "and", "these", "C0014442#ent", "<e2>", "in", "the", "transgenic", "animals"], "h": {"id": "C1417135", "name": "C1417135#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [27, 28]}}
{"token": ["C3540628#ent", "<e1>", ")", "or", "2", "years", "(", "C0292015#ent", "<e2>", ")", "for", "recovery", "."], "h": {"id": "C3540628", "name": "C3540628#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0292015", "name": "C0292015#ent", "pos": [7, 8]}}
{"token": ["The", "proportions", "of", "the", "two", "isoforms", "change", "with", "age", ",", "C3540628#ent", "<e1>", "expression", "increasing", "at", "the", "expense", "of", "C0292015#ent", "<e2>", "."], "h": {"id": "C3540628", "name": "C3540628#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0292015", "name": "C0292015#ent", "pos": [18, 19]}}
{"token": ["Statistically", "significant", "rises", "in", "C0242192#ent", "<e1>", "lactic", "dehydrogenase", "determinations", "occurred", "at", "exposures", "to", "C2240312#ent", "<e2>", "of", "0.8", "mg/m3", "and", "persisted", "at", "exposures", "of", "0.6", "mg/m3", "."], "h": {"id": "C0242192", "name": "C0242192#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2240312", "name": "C2240312#ent", "pos": [13, 14]}}
{"token": ["Interval", "cholecystectomy", "IC", ")", ",", "the", "removal", "of", "a", "C0277565#ent", "<e1>", "gallbladder", "after", "drainage", "for", "C0275518#ent", "<e2>", "is", "considered", "an", "appropriate", "procedure", "in", "suitable", "patients", "."], "h": {"id": "C0277565", "name": "C0277565#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0275518", "name": "C0275518#ent", "pos": [15, 16]}}
{"token": ["Two", "patients", "receiving", "hemodialysis", "for", "chronic", "renal", "failure", "C0035305#ent", "<e1>", "associated", "with", "multiple", "underlying", "C0154822#ent", "<e2>", "the", "pigment", "epithelium", "."], "h": {"id": "C0035305", "name": "C0035305#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0154822", "name": "C0154822#ent", "pos": [14, 15]}}
{"token": ["Due", "to", "its", "unique", "structure", "and", "extraordinary", "properties", ",", "the", "C4283882#ent", "<e1>", "polymer", "film", "shows", "higher", "accumulation", "efficiency", "toward", "C0053339#ent", "<e2>", "compared", "with", "a", "bare", "GCE", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0053339", "name": "C0053339#ent", "pos": [19, 20]}}
{"token": ["The", "propofol-uridine", "diphosphate-glucuronosyltransferase", "(", "C4284131#ent", "<e1>", ")", "activity", "measured", "in", "C0023899#ent", "<e2>", "microsomes", "was", "higher", "in", "rabbit", "than", "in", "rat", "."], "h": {"id": "C4284131", "name": "C4284131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["Food", "deprivation", "rainbow", "trout", "affected", "detoxification", "enzyme", "activities", ",", "namely", "glutathione-S-transferase", "(", "GST", ")", ",", "uridine-di-phosphate", "glucuronosyltransferase", "C4284131#ent", "<e1>", ")", "and", "glutathione", "reductase", "GR", ")", "activities", "in", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C4284131", "name": "C4284131#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [28, 29]}}
{"token": ["C0879590#ent", "<e1>", "IL-2", ")", "analogs", "with", "defined", "C2917660#ent", "<e2>", "substitutions", "were", "used", "to", "identify", "specific", "residues", "that", "interact", "with", "the", "55-kDa", "subunit", "(", "p55", ")", "or", "alpha", "chain", "of", "human", "IL-2", "receptor"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [7, 8]}}
{"token": ["Interleukin-2", "(", "C0879590#ent", "<e1>", ")", "is", "a", "133", "C2917660#ent", "<e2>", "alpha-helical", "protein", "secreted", "by", "activated", "T-cells", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [8, 9]}}
{"token": ["Our", "aims", "are", "to", "provide", "the", "beneficial", "references", "for", "further", "understanding", "the", "mechanism", "of", "evolution", "and", "alternative", "splicing", "of", "C1537501#ent", "<e1>", "and", "elucidating", "the", "C0536221#ent", "<e2>", "kininogen", "protein"], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [24, 25]}}
{"token": ["The", "kininogens", ",", "high", "molecular", "weight", "kininogen", "HK", ")", "and", "C1537501#ent", "<e1>", "LK", ")", ",", "are", "C0536221#ent", "<e2>", ",", "single-gene", "products", "that", "contain", "bradykinin", "and", "identical", "amino-terminal", "heavy", "chains", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [16, 17]}}
{"token": ["To", "ascertain", "whether", "expression", "of", "high-mannose", "type", "oligosaccharide", "is", "involved", "in", "C1412133#ent", "<e1>", "multinucleated", "cell", "MNC", ")", "formation", ",", "C1512211#ent", "<e2>", "used", "on", "RAW264.7", "cell", "culture", "."], "h": {"id": "C1412133", "name": "C1412133#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1512211", "name": "C1512211#ent", "pos": [19, 20]}}
{"token": ["A", "patient", "with", "C0003873#ent", "<e1>", "gold", "induced", "peripheral", "neuropathy", "255", "mgs", "of", "C0018033#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0018033", "name": "C0018033#ent", "pos": [12, 13]}}
{"token": ["A", "56", "year", "old", "woman", "with", "C0003873#ent", "<e1>", "relapsing", "thrombocytopenia", "successive", "treatments", "with", "C0018033#ent", "<e2>", ",", "sulphasalazine", ",", "and", "hydroxychloroquine", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0018033", "name": "C0018033#ent", "pos": [13, 14]}}
{"token": ["A", "43-year-old", "woman", "with", "C0003873#ent", "<e1>", "a", "selective", "IgA", "deficiency", "C0018033#ent", "<e2>", "treatment", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0018033", "name": "C0018033#ent", "pos": [10, 11]}}
{"token": ["C0036202#ent", "<e1>", "is", "a", "rare", ",", "but", "well-recognized", "cause", "of", "C4025821#ent", "<e2>", "with", "a", "predilection", "for", "the", "hypothalamus", "."], "h": {"id": "C0036202", "name": "C0036202#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4025821", "name": "C4025821#ent", "pos": [10, 11]}}
{"token": ["This", "relationship", "of", "hepatitis", "B", "C0040128#ent", "<e1>", "Down", "syndrome", "be", "explained", "by", "C1333196#ent", "<e2>", "and/or", "cellular", "immune", "abnormalities", "to", "extra", "genetic", "material", "trisomy", "21"], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "these", "cells", "were", "incapable", "of", "clonal", "expansion", "to", "defective", "synthesis", "of", "cyclin", "D3", "C1332694#ent", "<e1>", "and", "defective", "activation", "of", "C0243045#ent", "<e2>", "cdk6", ",", "and", "cdk2", "."], "h": {"id": "C1332694", "name": "C1332694#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [21, 22]}}
{"token": ["Four", "genes", "were", "recently", "identified", "to", "cause", "autosomal", "dominant", "C3540809#ent", "<e1>", ",", "including", "the", "C1826396#ent", "<e2>"], "h": {"id": "C3540809", "name": "C3540809#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826396", "name": "C1826396#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "fundus", "autofluorescence", "(", "C1421409#ent", "<e1>", ")", "findings", "in", "C0235267#ent", "<e2>", "with", "myopic", "choroidal", "neovascularisation", "CNV", ")", "."], "h": {"id": "C1421409", "name": "C1421409#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "C0018549#ent", "<e1>", "on", "maximal", "and", "submaximal", "C1413043#ent", "<e2>", "+", "-activated", "tension", "development", "of", "the", "contractile", "proteins", "newborn", "and", "adult", "cardiac", "muscle", "rabbits", "was", "determined", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [9, 10]}}
{"token": ["Experimental", "solutions", "saturated", "with", "C0018549#ent", "<e1>", "in", "N2", "gas", "C1413043#ent", "<e2>", "+", "uptake", "by", "SR", ",", "C1413043#ent", "<e2>", "+", "release", "by", "SR", ",", "or", "during", "both", "SR", "C1413043#ent", "<e2>", "+", "uptake", "and", "release", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [9, 10]}}
{"token": ["In", "a", "retrospective", "survey", "40", "infants", "with", "C1418963#ent", "<e1>", ",", "failure", "to", "C2938208#ent", "<e2>", "was", "found", "to", "be", "significantly", "correlated", "with", "the", "severity", "of", "the", "airflow", "obstruction", "."], "h": {"id": "C1418963", "name": "C1418963#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2938208", "name": "C2938208#ent", "pos": [12, 13]}}
{"token": ["The", "C0039082#ent", "<e1>", "of", "postmenopausal", "endocrine", "deficiency", "a", "C3887896#ent", "<e2>", "which", "in", "principle", "requires", "substitution", "with", "the", "secretory", "product", "the", "gland", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3887896", "name": "C3887896#ent", "pos": [8, 9]}}
{"token": ["Aromatic", "amine", "N-cation", "radicals", "formed", "by", "C0031179#ent", "<e1>", "were", "found", "to", "cooxidize", "C1260386#ent", "<e2>", "or", "NADH", "and", "form", "reactive", "oxygen", "species"], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [12, 13]}}
{"token": ["Selenite", "treatment", "produced", "slight", "decreases", "in", "C1260386#ent", "<e1>", "C0031179#ent", "<e2>", "activity", "but", "did", "not", "alter", "C1260386#ent", "<e1>", "S-transferase", "activity"], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [6, 7]}}
{"token": ["Expression", "of", "C1420182#ent", "<e1>", "was", "decreased", "in", "ADDP", ",", "LoVo-Li", "and", "AG6000", ",", "C1706343#ent", "<e2>", "decreased", "in", "ADDP", "and", "AG6000", "and", "OCT3", "in", "LoVo-175X2", ",", "compared", "to", "the", "parental", "cell", "lines"], "h": {"id": "C1420182", "name": "C1420182#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706343", "name": "C1706343#ent", "pos": [13, 14]}}
{"token": ["Both", "brain", "proteins", "preferentially", "modified", "by", "C1539895#ent", "<e1>", ",", "as", "compared", "with", "SUMO2", "or", "C1706247#ent", "<e2>", "."], "h": {"id": "C1539895", "name": "C1539895#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706247", "name": "C1706247#ent", "pos": [14, 15]}}
{"token": ["Clinicians", "should", "be", "alert", "to", "sporadic", "cases", "of", "both", "atypical", "and", "classic", "C2986600#ent", "<e1>", ",", "even", "in", "populations", "in", "which", "the", "prevalence", "of", "C0020097#ent", "<e2>", "low", "."], "h": {"id": "C2986600", "name": "C2986600#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020097", "name": "C0020097#ent", "pos": [23, 24]}}
{"token": ["Our", "findings", "suggest", "that", "the", "MRP", "and", "LRP", "genes", "in", "C2986600#ent", "<e1>", "are", "often", "activated", "by", "C0020097#ent", "<e2>", "may", "confer", "MDR", "of", "ATL", "cells", "in", "vivo"], "h": {"id": "C2986600", "name": "C2986600#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020097", "name": "C0020097#ent", "pos": [16, 17]}}
{"token": ["Inactivation", "of", "Ets2", "results", "in", "TS", "cell", "slower", "growth", ",", "increased", "expression", "of", "a", "subset", "of", "C3888243#ent", "<e1>", "decreased", "expression", "of", "several", "C1417679#ent", "<e2>", "implicated", "in", "TS", "self-renewal", "."], "h": {"id": "C3888243", "name": "C3888243#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [22, 23]}}
{"token": ["Recently", ",", "the", "dual", "reuptake", "inhibitor", "duloxetine", ",", "the", "atypical", "C0040615#ent", "<e1>", "desvenlafaxine", "(", "the", "main", "metabolite", "of", "C0078569#ent", "<e2>", ")", "were", "developed", "for", "the", "treatment", "of", "depression", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0078569", "name": "C0078569#ent", "pos": [18, 19]}}
{"token": ["Glucocorticoid", "excess", "causes", "C2936179#ent", "<e1>", "its", "accompanying", "insulin", "resistance", "C0242339#ent", "<e2>", "and", "hypertension", "."], "h": {"id": "C2936179", "name": "C2936179#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242339", "name": "C0242339#ent", "pos": [9, 10]}}
{"token": ["To", "our", "knowledge", ",", "this", "is", "the", "first", "C0035179#ent", "<e1>", "that", "serves", "as", "a", "dual", "inhibitor", "both", "C1416671#ent", "<e2>", "the", "papain-like", "cysteine", "proteinases", "employing", "an", "RSL-dependent", "inhibitory", "mechanism", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "RSL", "swaps", "between", "SCCA1", "and", "the", "nearly", "identical", "C0035179#ent", "<e1>", ",", "SCCA2", "(", "an", "inhibitor", "of", "C1416671#ent", "<e2>", ",", "reversed", "their", "target", "specificities", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [18, 19]}}
{"token": ["Both", "proteins", "are", "members", "of", "the", "high-molecular", "weight", "serine", "proteinase", "inhibitor", "(", "C0035179#ent", "<e1>", ")", "family", "with", "SCCA1", "paradoxically", "inhibiting", "lysosomal", "cysteine", "proteinases", "SCCA2", "inhibiting", "C1416671#ent", "<e2>"], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [25, 26]}}
{"token": ["Furthermore", ",", "C0257685#ent", "<e1>", "in", "the", "attenuation", "of", "the", "prenylated", "form", "of", "C0525678#ent", "<e2>", "."], "h": {"id": "C0257685", "name": "C0257685#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [12, 13]}}
{"token": ["Protein", "kinase", "C", "PKC", ")", ",", "p38", "MAP", "kinase", "and", "mitogen-activated", "protein", "kinase-activated", "kinases", "2", "3", "(", "MAPKAPK2", "and", "C1417028#ent", "<e1>", ")", "have", "been", "implicated", "in", "ischemic", "preconditioning", "C3810569#ent", "<e2>", ")", "of", "the", "heart", "to", "reduce", "damage", "following", "a", "myocardial", "infarct"], "h": {"id": "C1417028", "name": "C1417028#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [28, 29]}}
{"token": ["C1336604#ent", "<e1>", "displayed", "the", "same", "sequence", "specificity", "C1705002#ent", "<e2>", ",", "preferring", "arrays", "of", "TTAGGG", "repeats", "a", "binding", "substrate", "over", "TTAGGC", "and", "TTGGGG", "repeats", "."], "h": {"id": "C1336604", "name": "C1336604#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705002", "name": "C1705002#ent", "pos": [7, 8]}}
{"token": ["First", "recognized", "as", "an", "inhibitor", "of", "intravascular", "fibrinolysis", "it", "is", "now", "evident", "that", "C1705527#ent", "<e1>", "is", "a", "C0536221#ent", "<e2>", "actions", "that", "may", "be", "dependent", "on", "or", "independent", "of", "its", "protease", "inhibitory", "effects", "."], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [17, 18]}}
{"token": ["The", "nonspecific", "muscarinic", "antagonist", "scopolamine", "and", "the", "M1", "muscarinic", "receptor", "antagonist", "C0031978#ent", "<e1>", ",", "but", "neither", "the", "M2", "muscarinic", "antagonist", "methoctramine", "nor", "the", "C0242948#ent", "<e2>", "attenuated", "bradycardia", "."], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242948", "name": "C0242948#ent", "pos": [23, 24]}}
{"token": ["The", "second", "developed", "a", "myelodysplastic", "syndrome", "a", "similar", "C0521471#ent", "<e1>", "with", "histological", "features", "of", "C0036203#ent", "<e2>", "no", "systemic", "abnormalities", "from", "mild", "hypergammaglobulinaemia", "cutaneous", "anergy", "multiple", "recall", "antigens", "and", "activation", "of", "circulating", "monocytes", "."], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036203", "name": "C0036203#ent", "pos": [14, 15]}}
{"token": ["Ameloblastin", "(", "C1705549#ent", "<e1>", ",", "MIM", "*", "601259", ")", "C0079429#ent", "<e2>", "expresses", "an", "important", "protein", "(", "C1705549#ent", "<e1>", ")", ",", "present", "in", "the", "organic", "matrix", "enamel", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705549", "name": "C1705549#ent", "pos": [2, 3]}}
{"token": ["The", "increasing", "use", "of", "automated", "blood", "chemistry", "screens", "for", "serum", "calcium", "levels", "with", "improved", "methods", "in", "measuring", "parathyroid", "hormone", "C1705340#ent", "<e1>", ")", "levels", "have", "made", "the", "diagnosis", "of", "C0040128#ent", "<e2>", "common", "clinical", "problem"], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [28, 29]}}
{"token": ["Continuous", "infusion", "C1705340#ent", "<e1>", "into", "rats", "results", "in", "histological", "changes", "similar", "to", "C0040128#ent", "<e2>", "including", "increased", "bone", "formation", "focal", "bone", "resorption", "and", "severe", "peritrabecular", "fibrosis", ",", "whereas", "pulsatile", "C1705340#ent", "<e1>", "increases", "bone", "formation", "skeletal", "abnormalities"], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [12, 13]}}
{"token": ["Studies", "initiated", "to", "characterize", "C3887686#ent", "<e1>", "in", "freshly", "isolated", "rat", "blood", "lymphocytes", "significant", "mRNA", "of", "C0919426#ent", "<e2>", "in", "control", "blood", "lymphocytes"], "h": {"id": "C3887686", "name": "C3887686#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919426", "name": "C0919426#ent", "pos": [15, 16]}}
{"token": ["Molecular", "modelling", "substrates", "of", "C3887686#ent", "<e1>", "C0919426#ent", "<e2>", ")", "within", "the", "putative", "active", "site", "of", "C0919426#ent", "<e2>", "constructed", "from", "the", "CYP102", "crystal", "structure", "reported", "."], "h": {"id": "C3887686", "name": "C3887686#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919426", "name": "C0919426#ent", "pos": [6, 7]}}
{"token": ["Several", "mutant", "transfectants", "were", "more", "easily", "triggered", "via", "C2984141#ent", "<e1>", "than", "cells", "transfected", "with", "the", "C1883559#ent", "<e2>"], "h": {"id": "C2984141", "name": "C2984141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [15, 16]}}
{"token": ["The", "majority", "of", "episodic", "exacerbations", "of", "asthma", "are", "associated", "with", "C0042769#ent", "<e1>", "in", "particular", "with", "C0276447#ent", "<e2>"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0276447", "name": "C0276447#ent", "pos": [15, 16]}}
{"token": ["Worsening", "asthma", "control", "also", "associated", "with", "C0042769#ent", "<e1>", "in", "particular", "C0276447#ent", "<e2>"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0276447", "name": "C0276447#ent", "pos": [10, 11]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "evaluate", "efficacy", "and", "safety", "of", "the", "treatment", "with", "interferon", "alpha", "C1415900#ent", "<e1>", ")", "and", "ribavirin", "in", "C0019069#ent", "<e2>", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [23, 24]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "effects", "of", "lovastatin", "in", "spontaneously", "immortalized", "rat", "intestinal", "epithelial", "cells", "C4053648#ent", "<e1>", "and", "their", "C0079973#ent", "<e2>", "transformed", "clones", "."], "h": {"id": "C4053648", "name": "C4053648#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0079973", "name": "C0079973#ent", "pos": [21, 22]}}
{"token": ["The", "C0221406#ent", "<e1>", "of", "free", "oxygenic", "radical", "oxidative", "lesion", "and", "nitrogen", "oxide", "C0042402#ent", "<e2>", ")", "deficiency", "is", "inducted", "by", "hyperglycaemia", "and", "the", "activation", "of", "aldolase", "reductase"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [12, 13]}}
{"token": ["The", "ability", "of", "T", "and", "B", "lymphocytes", "undergo", "C1706669#ent", "<e1>", "the", "presence", "of", "PHA", "and", "C0030360#ent", "<e2>", ",", "respectively", ",", "was", "not", "affected", "by", "in", "vitro", "exposure", "of", "lymphoid", "cells", "carrageenan", "."], "h": {"id": "C1706669", "name": "C1706669#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030360", "name": "C0030360#ent", "pos": [15, 16]}}
{"token": ["C0286185#ent", "<e1>", "also", "inhibits", "C1142644#ent", "<e2>", "consequently", "inhibits", "its", "own", "metabolism", ",", "a", "property", "illustrated", "by", "three", "studies", "performed", "early", "in", "the", "drug", "'s", "development", "."], "h": {"id": "C0286185", "name": "C0286185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [4, 5]}}
{"token": ["C0286185#ent", "<e1>", "is", "metabolized", "via", "parallel", "pathways", "esterase-catalysed", "hydrolysis", "and", "C1142644#ent", "<e2>"], "h": {"id": "C0286185", "name": "C0286185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [10, 11]}}
{"token": ["C0270952#ent", "<e1>", "OPMD", ")", "is", "an", "adult-onset", "disorder", "by", "progressive", "eyelid", "drooping", "C0011168#ent", "<e2>", "proximal", "limb", "weakness"], "h": {"id": "C0270952", "name": "C0270952#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [12, 13]}}
{"token": ["Adrimycin", ",", "ifosfamide", ",", "and", "C0010927#ent", "<e1>", "are", "the", "most", "effective", "C0991617#ent", "<e2>", "at", "present", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [11, 12]}}
{"token": ["C0760826#ent", "<e1>", "did", "not", "interact", "with", "the", "C0038766#ent", "<e2>", "binding", "site", "with", "the", "non-I1", "and", "non-I2", "imidazoline", "site", "in", "the", "beta", "cells", "is", "recognized", "by", "the", "imidazoline", "compounds", "efaroxan", ",", "phentolamine", "and", "RX821002", "."], "h": {"id": "C0760826", "name": "C0760826#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [7, 8]}}
{"token": ["The", "enzymes", "phosphoglucomutase", "3", "PGM3", ")", ",", "glyoxalase", "1", "C0919524#ent", "<e1>", ")", ",", "mitochondrial", "superoxide", "dismutase", "SOD2", ")", ",", "and", "soluble", "C1417092#ent", "<e2>", "ME1", ")", "were", "assayed", "in", "those", "hybrids", "where", "electrophoretic", "separations", "be", "achieved", "."], "h": {"id": "C0919524", "name": "C0919524#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417092", "name": "C1417092#ent", "pos": [21, 22]}}
{"token": ["In", "the", "present", "study", ",", "we", "have", "tested", "this", "hypothesis", "by", "using", "deoxynojirimycin", "and", "derivatives", "as", "chemical", "chaperones", "correct", "the", "C0086648#ent", "<e1>", "cultured", "fibroblasts", "from", "patients", "with", "C0268147#ent", "<e2>", "."], "h": {"id": "C0086648", "name": "C0086648#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0268147", "name": "C0268147#ent", "pos": [27, 28]}}
{"token": ["Recent", "studies", "have", "shown", "that", "the", "C0242947#ent", "<e1>", "pilocarpine", "induces", "C0087140#ent", "<e2>", "mRNA", "in", "rat", "cortex"], "h": {"id": "C0242947", "name": "C0242947#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [10, 11]}}
{"token": ["The", "incidence", ",", "onset", "and", "severity", "of", "C0701807#ent", "<e1>", "extent", "of", "photoreceptor", "destruction", "related", "to", "both", "C0010592#ent", "<e2>", "dose", "and", "nature", "of", "challenge", "."], "h": {"id": "C0701807", "name": "C0701807#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [16, 17]}}
{"token": ["Fifty-six", "patients", "with", "bilateral", "sight-threatening", "noninfectious", "intermediate", "or", "C0701807#ent", "<e1>", "in", "a", "randomized", "double-masked", "study", "the", "use", "of", "C0010592#ent", "<e2>", "vs", "prednisolone", "in", "their", "treatment", "."], "h": {"id": "C0701807", "name": "C0701807#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [18, 19]}}
{"token": ["At", "least", "one", "C2348192#ent", "<e1>", "expressed", "in", "92", "%", "and", "C3538869#ent", "<e2>", "in", "57.7", "%", "of", "the", "cases", "."], "h": {"id": "C2348192", "name": "C2348192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538869", "name": "C3538869#ent", "pos": [10, 11]}}
{"token": ["Immunofluorescence", "of", "developing", "mouse", "vertebrae", "showed", "that", "CTGF", ",", "TGF-beta1", "and", "C1367472#ent", "<e1>", "were", "co-expressed", "in", "condensations", "of", "MCs", ",", "while", "C1420331#ent", "<e2>", "expression", "was", "low", "at", "this", "stage", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420331", "name": "C1420331#ent", "pos": [21, 22]}}
{"token": ["There", "was", "no", "effect", "of", "C0002333#ent", "<e1>", "on", "the", "single-dose", "or", "steady-state", "pharmacokinetics", "of", "nefazodone", ",", "C0068485#ent", "<e2>", ",", "or", "dione", "after", "the", "coadministration", "of", "C0002333#ent", "<e1>", "and", "nefazodone", "."], "h": {"id": "C0002333", "name": "C0002333#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0068485", "name": "C0068485#ent", "pos": [16, 17]}}
{"token": ["The", "authors", "report", "the", "case", "of", "an", "8-month-old", "Omani", "female", "infant", "with", "C0221023#ent", "<e1>", "as", "severe", "fungal", "(", "Candida", ")", "C0001327#ent", "<e2>", "needing", "life-saving", "tracheostomy", "and", "i.v", "."], "h": {"id": "C0221023", "name": "C0221023#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001327", "name": "C0001327#ent", "pos": [20, 21]}}
{"token": ["The", "ability", "of", "these", "C0035064#ent", "<e1>", "to", "inhibit", "C3887659#ent", "<e2>", "has", "been", "investigated", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887659", "name": "C3887659#ent", "pos": [8, 9]}}
{"token": ["The", "main", "aim", "of", "the", "present", "study", "was", "to", "evaluate", "whether", "inhaled", "C0073992#ent", "<e1>", "given", "in", "the", "evening", "protected", "against", "C0004099#ent", "<e2>", "next", "morning"], "h": {"id": "C0073992", "name": "C0073992#ent", "pos": [12, 13]}, "relation": "may_prevent", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [20, 21]}}
{"token": ["This", "study", "confirms", "that", "the", "longer", "duration", "of", "effect", "of", "C0073992#ent", "<e1>", "and", "its", "superiority", "by", "comparison", "with", "the", "standard", "treatments", "C0004099#ent", "<e2>"], "h": {"id": "C0073992", "name": "C0073992#ent", "pos": [10, 11]}, "relation": "may_prevent", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [21, 22]}}
{"token": ["The", "effect", "of", "Y-27632", "was", "mimicked", "by", "another", "Rho", "kinase", "inhibitor", "C0877871#ent", "<e1>", ",", "but", "not", "by", "the", "C1415545#ent", "<e2>", "GF-109203X", "or", "the", "protein", "kinase", "A", "inhibitor", "KT5720", "."], "h": {"id": "C0877871", "name": "C0877871#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415545", "name": "C1415545#ent", "pos": [18, 19]}}
{"token": ["In", "clinical", "studies", "both", "hospitalized", "and", "outpatient", "populations", "C1321744#ent", "<e1>", "has", "been", "highly", "effective", "in", "the", "treatment", "of", "C0206171#ent", "<e2>", "acute", "exacerbation", "chronic", "bronchitis"], "h": {"id": "C1321744", "name": "C1321744#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0206171", "name": "C0206171#ent", "pos": [18, 19]}}
{"token": ["Due", "to", "its", "potent", "activity", "against", "many", "common", "gram-positive", "and", "gram-negative", "respiratory", "pathogens", "its", "proven", "clinical", "efficacy", "and", "its", "favorable", "safety", "profile", ",", "C1321744#ent", "<e1>", "is", "a", "highly", "effective", "empiric", "treatment", "C0206171#ent", "<e2>", "lower", "respiratory", "tract", "infections"], "h": {"id": "C1321744", "name": "C1321744#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0206171", "name": "C0206171#ent", "pos": [31, 32]}}
{"token": ["In", "contrast", ",", "C0011501#ent", "<e1>", "did", "increase", "feeding", "and", "the", "binding", "of", "[3H]ouabain", "and", "C0024977#ent", "<e2>", "to", "the", "hypothalamus", "of", "lean", "littermates.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024977", "name": "C0024977#ent", "pos": [14, 15]}}
{"token": ["We", "have", "previously", "shown", "that", "CD40", "causes", "strong", "activation", "of", "the", "c-Jun", "N-terminal", "kinase", "JNK", ")", ",", "the", "p38", "mitogen-activated", "protein", "kinases", "C1370600#ent", "<e1>", ")", "and", "MAPKAP", "kinase-2", "a", "downstream", "target", "of", "C1456380#ent", "<e2>"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [22, 23]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [32, 33]}}
{"token": ["Our", "results", "show", "that", "crosslinking", "mIgM", "but", "not", "mIgD", "induced", "a", "delayed", "and", "sustained", "activation", "of", "the", "mitogen-activated", "protein", "kinase", "C1370600#ent", "<e1>", ")", "family", "members", "stress-activated", "protein", "kinase", "SAPK", ")", "and", "C1456380#ent", "<e2>"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [31, 32]}}
{"token": ["CD48", "is", "a", "member", "of", "the", "C1425097#ent", "<e1>", "cell", "surface", "expression", "is", "strikingly", "up-regulated", "on", "the", "surface", "of", "C0149678#ent", "<e2>"], "h": {"id": "C1425097", "name": "C1425097#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [18, 19]}}
{"token": ["Various", "C0039052#ent", "<e1>", "discussed", ",", "including", "the", "choline", "esters", "C0106169#ent", "<e2>", ",", "carbachol", ",", "methacholine", "chloride", "and", "furtrethonium", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0106169", "name": "C0106169#ent", "pos": [9, 10]}}
{"token": ["Ketoconazole", "is", "not", "the", "recommended", "C0013227#ent", "<e1>", "for", "treatment", "of", "C0038034#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038034", "name": "C0038034#ent", "pos": [10, 11]}}
{"token": ["It", "is", "well", "known", "that", "potassium", "iodide", "the", "C0013227#ent", "<e1>", "of", "choice", "for", "C0038034#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038034", "name": "C0038034#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "test", "the", "hypothesis", "that", "the", "cis-acting", "repression", "domain", "is", "a", "conserved", "feature", "of", "PAX3", "and", "C1335194#ent", "<e1>", "and", "that", "C1850988#ent", "<e2>", "similarly", "."], "h": {"id": "C1335194", "name": "C1335194#ent", "pos": [17, 18]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1850988", "name": "C1850988#ent", "pos": [21, 22]}}
{"token": ["C0409974#ent", "<e1>", "a", "rare", "manifestation", "of", "C0024138#ent", "<e2>", "."], "h": {"id": "C0409974", "name": "C0409974#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [6, 7]}}
{"token": ["AC", "activity", "was", "approximately", "sevenfold", "higher", "in", "P", "than", "in", "C1824810#ent", "<e1>", "under", "basal", "and", "stimulated", "conditions", "(", "MnCl(2)/GTP/GTP", "+", "C0282210#ent", "<e2>", ")", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [20, 21]}}
{"token": ["C1335843#ent", "<e1>", "mutations", "coexisted", "with", "mutations/deletions", "at", "KRAS", ",", "LKB1", ",", "C0027260#ent", "<e2>", ",", "P16", ",", "and", "P53", "."], "h": {"id": "C1335843", "name": "C1335843#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027260", "name": "C0027260#ent", "pos": [11, 12]}}
{"token": ["Among", "199,642", "newborns", ",", "nine", "cases", "with", "C0016952#ent", "<e1>", "three", "with", "C0751161#ent", "<e2>", "six", "with", "compound", "Duarte2/heterozygotes", "for", "galactosaemia", "and", "four", "with", "compound2", "Duarte", "homozygosity", "found", "."], "h": {"id": "C0016952", "name": "C0016952#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0751161", "name": "C0751161#ent", "pos": [11, 12]}}
{"token": ["Both", "proteins", "contain", "N-terminal", "myristylation", "sites", "localization", "on", "the", "plasma", "membrane", "a", "PTB", "domain", "binding", "to", "limited", "species", "of", "receptor", "tyrosine", "kinases", "RTKs", ")", ",", "including", "the", "C1333542#ent", "<e1>", "the", "neurotophin", "receptor", "RET", ",", "and", "C1704943#ent", "<e2>", "."], "h": {"id": "C1333542", "name": "C1333542#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1704943", "name": "C1704943#ent", "pos": [35, 36]}}
{"token": ["All", "3", "patients", "had", "previously", "been", "extensively", "treated", "with", "standard", "therapies", "ICRP", "including", ":", "diphenhydramine", ",", "C0008281#ent", "<e1>", ",", "cholestyramine", ",", "rifampicin", ",", "phenobarbital", ",", "doxepin", ",", "C2343921#ent", "<e2>", ",", "UV", "therapy", "and", "topical", "lotions"], "h": {"id": "C0008281", "name": "C0008281#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2343921", "name": "C2343921#ent", "pos": [27, 28]}}
{"token": ["In", "conclusion", ",", "this", "study", "suggests", "that", "therapy", "with", "C0360714#ent", "<e1>", "in", "patients", "with", "coronary", "artery", "disease", "atrial", "fibrillation", "associated", "with", "increase", "in", "C0009325#ent", "<e2>", "degradation", "and", "an", "attenuation", "of", "inflammation", ",", "independently", "of", "cholesterol", "lowering"], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [23, 24]}}
{"token": ["Cholesterol", "lowering", "by", "azalanstat", "and", "C0008402#ent", "<e1>", "was", "additive", ",", "and", "the", "increase", "in", "C0020374#ent", "<e2>", "about", "by", "C0008402#ent", "<e1>", "was", "attenuated", "significantly", "by", "azalanstat", "."], "h": {"id": "C0020374", "name": "C0020374#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [5, 6]}}
{"token": ["Twenty-two", "subjects", "had", "been", "treated", "with", "diet", "alone", ",", "35", "with", "diet", "and", "fibrates", ",", "37", "with", "diet", "and", "C0020374#ent", "<e1>", "HMG", "CoA)", "reductase", "inhibitors", "statins", ")", ",", "and", "eight", "with", "diet", "and", "C0008402#ent", "<e2>", "."], "h": {"id": "C0020374", "name": "C0020374#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [33, 34]}}
{"token": ["To", "determine", "whether", "C1418273#ent", "<e1>", "haploinsufficiency", "plays", "a", "role", "in", "C1861689#ent", "<e2>", ",", "we", "have", "defined", "the", "gene", "structure", "the", "human", "PAX1", "gene", "screened", "63", "C1861689#ent", "<e2>", "patients", "for", "mutations", "in", "this", "gene", "."], "h": {"id": "C1418273", "name": "C1418273#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1861689", "name": "C1861689#ent", "pos": [10, 11]}}
{"token": ["The", "significance", "of", "these", "results", "and", "the", "possible", "role", "of", "C1418273#ent", "<e1>", "in", "the", "pathogenesis", "of", "C1861689#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C1418273", "name": "C1418273#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1861689", "name": "C1861689#ent", "pos": [16, 17]}}
{"token": ["These", "data", "indicate", "that", "C2698739#ent", "<e1>", "is", "not", "well", "coupled", "to", "the", "C0086376#ent", "<e2>"], "h": {"id": "C2698739", "name": "C2698739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["In", "vessels", "from", "C4284124#ent", "<e1>", "treatment", "with", "C0058903#ent", "<e2>", "decreased", "peroxynitrite", "(", "ONOO-", ")", "formation", "and", "improved", "the", "reduced", "FMD", ",", "largely", "due", "to", "restoration", "of", "the", "presumed", "EDHF", "component", "."], "h": {"id": "C4284124", "name": "C4284124#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0058903", "name": "C0058903#ent", "pos": [7, 8]}}
{"token": ["The", "HIV-1", "Rev", "regulatory", "protein", "an", "activation", "domain", "C1705625#ent", "<e1>", ")", "and", "a", "RNA", "binding", "domain", "C0015923#ent", "<e2>", ")", "."], "h": {"id": "C1705625", "name": "C1705625#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015923", "name": "C0015923#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "EGF", "does", "not", "affect", "the", "expression", "of", "other", "signal", "transduction", "C1335817#ent", "<e1>", "such", "as", "phospholipase", "C", "gamma", "1", "the", "C1418577#ent", "<e2>", "phosphatidylinositide", "3-kinase"], "h": {"id": "C1335817", "name": "C1335817#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418577", "name": "C1418577#ent", "pos": [22, 23]}}
{"token": ["On", "the", "other", "hand", ",", "removal", "of", "C0146953#ent", "<e1>", "the", "detergent", "phase", "containing", "amphiphilic", "ChAT", "activity", "led", "to", "C0027203#ent", "<e2>", "aggregation", "."], "h": {"id": "C0146953", "name": "C0146953#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["Steady-state", "levels", "of", "C3273828#ent", "<e1>", "mRNA", "and", "protein", "were", "not", "affected", "by", "C2936882#ent", "<e2>", "."], "h": {"id": "C3273828", "name": "C3273828#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [12, 13]}}
{"token": ["The", "urinary", "clearance", "of", "C0034262#ent", "<e1>", "was", "studied", "in", "six", "patients", "with", "C0026896#ent", "<e2>"], "h": {"id": "C0034262", "name": "C0034262#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [12, 13]}}
{"token": ["C1336679#ent", "<e1>", "through", "the", "stimulatory", "G", "protein", "Gs", ")", "to", "activate", "C1382029#ent", "<e2>", "the", "enzyme", "responsible", "for", "cAMP", "production", "."], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [11, 12]}}
{"token": ["The", "molecular", "mechanism", "the", "autonomous", "growth", "and", "function", "of", "these", "nodules", "has", "been", "related", "to", "mutations", "in", "the", "thyrotropin", "receptor", "C1336679#ent", "<e1>", ")", "that", "constitutively", "activate", "the", "C1382029#ent", "<e2>"], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [27, 28]}}
{"token": ["Similarly", ",", "the", "activity", "of", "C0065865#ent", "<e1>", "was", "elevated", "by", "the", "high", "dose", "C0039286#ent", "<e2>", "at", "the", "latest", "time", "points", "and", "a", "further", "elevation", "was", "seen", "in", "tamoxifen-induced", "liver", "tumors", "."], "h": {"id": "C0065865", "name": "C0065865#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [13, 14]}}
{"token": ["In", "acute", "migraine", "combination", "of", "C0033493#ent", "<e1>", ",", "a", "centrally", "acting", "analgesic", ",", "with", "acetylsalicylic", "acid", "C0003420#ent", "<e2>", "gives", "an", "alternative", "to", "ergotamine", "tartrate", "is", "equally", "effective", "and", "causes", "less", "nausea", "and", "vomiting", "."], "h": {"id": "C0033493", "name": "C0033493#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003420", "name": "C0003420#ent", "pos": [16, 17]}}
{"token": ["To", "ascertain", "the", "efficiency", "of", "different", "techniques", "of", "arthroscopic", "therapy", "C0158026#ent", "<e1>", "and", "establish", "the", "relevance", "of", "the", "extent", "of", "C0085700#ent", "<e2>", ",", "clinical", "and", "experimental", "studies", "performed", "."], "h": {"id": "C0158026", "name": "C0158026#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085700", "name": "C0085700#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "imply", "that", "LAM", "may", "contribute", "to", "the", "immunologic", "defects", "associated", "with", "number", "of", "C0026918#ent", "<e1>", "modulating", "these", "C0127400#ent", "<e2>", "."], "h": {"id": "C0026918", "name": "C0026918#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [19, 20]}}
{"token": ["C0005382#ent", "<e1>", ",", "such", "as", "C0025598#ent", "<e2>", ",", "and", "thiazolidinediones", "(", "TZDs", ")", ",", "such", "as", "pioglitazone", ",", "improve", "insulin", "resistance"], "h": {"id": "C0005382", "name": "C0005382#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [5, 6]}}
{"token": ["To", "describe", "recent", "developments", "in", "the", "pharmacological", "treatment", "C0042571#ent", "<e1>", "and", "nystagmus", "while", "focusing", "on", "vestibular", "neuritis", "Meniere's", "disease", "downbeat", "nystagmus", "C0271382#ent", "<e2>", "acquired", "pendular", "nystagmus", "and", "superior", "oblique", "myokymia"], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0271382", "name": "C0271382#ent", "pos": [21, 22]}}
{"token": ["Following", "single", "dosage", "of", "pentazocine", "subjects", "more", "often", "reported", "a", "general", "feeling", "of", "C0231218#ent", "<e1>", ",", "including", "nausea", ",", "dizziness", "and", "C0026603#ent", "<e2>", "than", "was", "the", "case", "after", "administration", "of", "flupirtine", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [21, 22]}}
{"token": ["In", "humans", "the", "intersensory", "conflict", "may", "additionally", "lead", "to", "a", "C0231218#ent", "<e1>", "commonly", "referred", "to", "as", "C0026603#ent", "<e2>", "SMS", ")", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [16, 17]}}
{"token": ["In", "humans", ",", "the", "intersensory", "conflict", "may", "additionally", "lead", "to", "a", "C0231218#ent", "<e1>", ",", "commonly", "referred", "to", "as", "C0026603#ent", "<e2>", "SMS", ")", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [18, 19]}}
{"token": ["Some", "adverse", "effects", "beta-blockers", "in", "C0018801#ent", "<e1>", "counteracted", "by", "C0017887#ent", "<e2>", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [9, 10]}}
{"token": ["Nesiritide", "is", "an", "attractive", "therapeutic", "option", "because", "of", "its", "more", "rapid", "and", "sustained", "hemodynamic", "profile", "with", "less", "adverse", "effects", "alternative", "C0018801#ent", "<e1>", "treatments", ",", "such", "as", "C0017887#ent", "<e2>", "or", "dobutamine", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [20, 21]}, "relation": "may_be_treated_by", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [26, 27]}}
{"token": ["One-hundred-and-ninety-two", "elderly", "patients", "with", "symptoms", "of", "C0018801#ent", "<e1>", "despite", "therapy", "with", "diuretics", "and", "inotropic", "agents", "received", "C0017887#ent", "<e2>", "additional", "medication", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [16, 17]}}
{"token": ["Loss", "of", "HMGN1", "elevates", "the", "amount", "of", "C1333913#ent", "<e1>", "bound", "to", "C1420331#ent", "<e2>", ",", "suggesting", "functional", "redundancy", "among", "these", "proteins", "."], "h": {"id": "C1333913", "name": "C1333913#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420331", "name": "C1420331#ent", "pos": [11, 12]}}
{"token": ["C0546849#ent", "<e1>", "inhibits", "a", "C0033681#ent", "<e2>", "rat", "brain", "extracts", "."], "h": {"id": "C0546849", "name": "C0546849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [4, 5]}}
{"token": ["Inhibitory", "sulfonylureas", "(", "SUs", ")", "have", "been", "used", "successfully", "to", "treat", "C0011849#ent", "<e1>", "in", "patients", "with", "activating", "C1416578#ent", "<e2>", "mutations", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416578", "name": "C1416578#ent", "pos": [17, 18]}}
{"token": ["Thirty-five", "to", "50", "%", "of", "patients", "diagnosed", "with", "C0011849#ent", "<e1>", "before", "6", "months", "have", "a", "mutation", "in", "C1416578#ent", "<e2>", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416578", "name": "C1416578#ent", "pos": [17, 18]}}
{"token": ["A", "patient", "with", "C0026946#ent", "<e1>", "a", "rapid", "clearing", "of", "candidiasis", ",", "but", "her", "C0019655#ent", "<e2>", "did", "not", "respond", "to", "three", "weeks", "of", "treatment", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [13, 14]}}
{"token": ["Adrenal", "involvement", "is", "very", "frequent", "in", "C0026946#ent", "<e1>", "such", "as", "C0019655#ent", "<e2>", "(", "Histoplasma", "capsulatum", ",", "cryptococcosis", "(", "Cryptococcus", "neoformans", ",", "and", "paracoccidioidomycosis", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [10, 11]}}
{"token": ["Liver", "disease", "steatosis", "and", "C1623038#ent", "<e1>", ")", "6", "months", "after", "bypass", ",", "together", "with", "C0856727#ent", "<e2>", "2/6", "patients", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [14, 15]}}
{"token": ["The", "results", "suggest", "that", ",", "in", "spite", "of", "the", "disturbances", "of", "bile", "acid", "metabolism", "generally", "seen", "in", "C1623038#ent", "<e1>", ",", "such", "patients", "are", "not", "prone", "to", "develop", "C0856727#ent", "<e2>"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [27, 28]}}
{"token": ["Of", "the", "21", "patients", "with", "C1623038#ent", "<e1>", "subjected", "to", "cholecystectomy", "for", "cholecystitis", "and", "C0856727#ent", "<e2>", ",", "nine", "had", "uncomplicated", "courses", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [13, 14]}}
{"token": ["To", "compare", "the", "sonographic", "features", "of", "gallbladder", "in", "symptomatic", "calculous", "cholecystitis", "C1623038#ent", "<e1>", "with", "silent", "C0856727#ent", "<e2>", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [15, 16]}}
{"token": ["DNA", "sequence", "comparison", "of", "the", "C0598349#ent", "<e1>", "trypsin", "and", "C0002245#ent", "<e2>", "reveals", "a", "conserved", "13", "nucleotide", "motif", "their", "5'-flanking", "regions"], "h": {"id": "C0598349", "name": "C0598349#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [9, 10]}}
{"token": ["C1366449#ent", "<e1>", "PAR-1", ")", "is", "a", "G-coupled", "receptor", "by", "thrombin", "and", "other", "C0030940#ent", "<e2>", "to", "expose", "a", "new", "N-terminus", ",", "a", "\"", "tethered", "ligand", "\"", ",", "that", "activates", "the", "receptor", "."], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [12, 13]}}
{"token": ["Collagenous", "colitis", "an", "C1290884#ent", "<e1>", "is", "included", "in", "the", "microscopic", "C0014356#ent", "<e2>", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014356", "name": "C0014356#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "whether", "these", "four", "mutations", "play", "a", "causative", "role", "in", "PS", "deficiency", "the", "four", "PS", "mutants", "and", "C2987364#ent", "<e1>", "PS", "were", "stably", "expressed", "in", "human", "embryo", "kidney", "C1704817#ent", "<e2>", ")", "293", "cells", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704817", "name": "C1704817#ent", "pos": [28, 29]}}
{"token": ["C1418640#ent", "<e1>", "or", "PKC", "inhibitors", "did", "not", "affect", "FGF-", "or", "EGF-mediated", "C1370600#ent", "<e2>", "activation", "."], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [11, 12]}}
{"token": ["Hence", ",", "we", "have", "identified", "a", "novel", "adapter", "function", "C1418640#ent", "<e1>", "in", "EPO", "signaling", "in", "which", "recruitment", "of", "C1418640#ent", "<e1>", "to", "EPO-R", "may", "lead", "to", "activation", "of", "the", "C1370600#ent", "<e1>", "pathway", "."], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [28, 29]}}
{"token": ["To", "evaluate", "the", "potential", "bleeding", "risks", "of", "arthrocentesis", "in", "patients", "with", "different", "C0152087#ent", "<e1>", "and", "taking", "C0003280#ent", "<e2>"], "h": {"id": "C0152087", "name": "C0152087#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [16, 17]}}
{"token": ["Blood", "lactate", "concentrations", "measured", "with", "the", "C0376261#ent", "<e1>", "from", "0.8", "-", "17.6", "mmol/liter", "and", "with", "the", "C0000744#ent", "<e2>", "from", "1.0", "-", "18.6", "mmol/liter", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [16, 17]}}
{"token": ["Together", ",", "these", "results", "demonstrate", "that", "PKC", "alpha", "C3537450#ent", "<e1>", "neuronal", "migration", "by", "activating", "focal", "adhesion", "complex", "proteins", "as", "p130Cas", "and", "C1704657#ent", "<e2>", "."], "h": {"id": "C3537450", "name": "C3537450#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704657", "name": "C1704657#ent", "pos": [21, 22]}}
{"token": ["In", "summary", ",", "the", "prenatal", "exposure", "to", "C1839163#ent", "<e1>", "affected", "the", "expression", "of", "the", "C0017337#ent", "<e2>", "the", "activity", "of", "this", "enzyme", "in", "brain", "catecholaminergic", "neurons", "during", "early", "fetal", "brain", "development"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["Between", "4", "and", "8", "h", ",", "SNAP", "and", "NONOate", "caused", "a", "2-", "to", "3-fold", "increase", "in", "C1328053#ent", "<e1>", ",", "but", "not", "iNOS", ",", "C0079429#ent", "<e2>", "(", "P", "<", "0.05", ")", "and", "protein", "expression"], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "the", "anaplerotic", "substrate", "alanine", "not", "only", "accelerates", "the", "disposal", "of", "C0000975#ent", "<e1>", "but", "also", "prevents", "the", "C0235394#ent", "<e2>", "of", "the", "latter", "compound", "as", "CO(2", ")", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0235394", "name": "C0235394#ent", "pos": [19, 20]}}
{"token": ["In", "cyanobacteria", ",", "red", "algae", "and", "C0257217#ent", "<e1>", ",", "HO", "is", "a", "key", "C0027203#ent", "<e2>", "in", "the", "synthesis", "of", "the", "chromophoric", "part", "of", "the", "photosynthetic", "antennae", "."], "h": {"id": "C0257217", "name": "C0257217#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}}
{"token": ["Both", "activities", "were", "inhibited", "by", "carbon", "monoxide", "cytochrome", "c.", "properties", "suggest", "that", "the", "3beta-hydroxylation", "of", "GA12-aldehyde", "and", "further", "oxidation", "of", "C0524928#ent", "<e1>", "7", "are", "catalyzed", "by", "C0111840#ent", "<e2>", "Gibberella", "fujikuroi", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0111840", "name": "C0111840#ent", "pos": [26, 27]}}
{"token": ["Examination", "of", "beta-galactosidase", "activity", "from", "a", "chromosomal", "phi(sodA'-'lacZ", ")", "fusion", "suggests", "that", "metallated", "C0287990#ent", "<e1>", "as", "a", "transcriptional", "repressor", "sodA", "(", "C0024708#ent", "<e2>", "MnSOD", "]", ")", "."], "h": {"id": "C0287990", "name": "C0287990#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024708", "name": "C0024708#ent", "pos": [21, 22]}}
{"token": ["We", "compared", "the", "involvement", "of", "C1413844#ent", "<e1>", "versus", "Nox4", "in", "redox-sensitive", "protein", "kinase", "activation", "after", "C0243192#ent", "<e2>", "stimulation", "."], "h": {"id": "C1413844", "name": "C1413844#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [15, 16]}}
{"token": ["Urine", "of", "four", "C0220994#ent", "<e1>", "patients", "who", "were", "treated", "with", "amounts", "of", "C0142805#ent", "<e2>", "analyzed", "."], "h": {"id": "C0220994", "name": "C0220994#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0142805", "name": "C0142805#ent", "pos": [12, 13]}}
{"token": ["CYP27A1", ",", "C1522417#ent", "<e1>", ",", "and", "CYP24A1", "are", "members", "of", "the", "C0010762#ent", "<e2>", "and", "key", "enzymes", "of", "vitamin", "D(3", ")", "metabolism", "."], "h": {"id": "C1522417", "name": "C1522417#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [11, 12]}}
{"token": ["Clinical", "course", "C0025297#ent", "<e1>", "was", "mild", "and", "was", "identical", "with", "previously", "manifestation", "of", "C0025289#ent", "<e2>"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [13, 14]}}
{"token": ["Cases", "of", "C0025289#ent", "<e1>", "were", "classified", "as", "tuberculous", "meningitis", "TBM", ")", ",", "pyogenic", "meningitis", "viral", "meningitis", "self-resolving", "C0025297#ent", "<e2>", "a", "specific", "diagnosis", ",", "C0025289#ent", "<e1>", "associated", "with", "infections", ",", "and", "neoplastic", "meningitis"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [17, 18]}, "relation": "has_nichd_parent", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [2, 3]}}
{"token": ["C0001486#ent", "<e1>", "12", "early", "region", "1A", "(", "C1863051#ent", "<e2>", "and", "Ad12", "E1A", ")", "proteins", "were", "cleaved", "during", "cisplatin-induced", "apoptosis", "of", "Ad-transformed", "rat", "and", "human", "cells"], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1863051", "name": "C1863051#ent", "pos": [7, 8]}}
{"token": ["We", "have", "developed", "and", "evaluated", "the", "reverse", "transcription", "detection", "of", "mRNA", "in", "cell", "culture", "assay", "C0001486#ent", "<e1>", "Ads", ")", "by", "using", "Ad", "type", "2", "C1863051#ent", "<e2>", ")", "and", "Ad41", "as", "models", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1863051", "name": "C1863051#ent", "pos": [24, 25]}}
{"token": ["Yet", ",", "a", "catalytically", "active", "protease", "was", "unable", "to", "convert", "a", "catalytically", "inactive", "C0030946#ent", "<e1>", "into", "the", "C3641819#ent", "<e2>"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3641819", "name": "C3641819#ent", "pos": [17, 18]}}
{"token": ["Despite", "the", "high", "degree", "of", "homology", "between", "human", "and", "bovine", "Rac2", ",", "some", "of", "the", "anti-peptide", "antibody", "probes", "prepared", "against", "human", "C1419228#ent", "<e1>", "failed", "to", "recognize", "the", "C1334043#ent", "<e2>"], "h": {"id": "C1419228", "name": "C1419228#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [27, 28]}}
{"token": ["The", "laforin-malin", "complex", "caused", "proteasome-dependent", "degradation", "of", "the", "C1332163#ent", "<e1>", "targeting", "to", "glycogen", ",", "PTG", ",", "which", "brings", "C0031686#ent", "<e2>", "MGS", "for", "activation", ",", "and", "of", "MGS", "itself", "."], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [18, 19]}}
{"token": ["According", "to", "C0015634#ent", "<e1>", "opinion", "obtained", "with", "matrix", "scoring", "chemical", "fertilizers", "sheep", "penning", "cheaper", "compared", "to", "C2697656#ent", "<e2>", "compost", "or", "urban", "solid", "waste", "compost", "."], "h": {"id": "C0015634", "name": "C0015634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [16, 17]}}
{"token": ["C0020207#ent", "<e1>", "is", "a", "drug", "used", "for", "the", "clinical", "treatment", "C0036329#ent", "<e2>", ",", "although", "inducing", "chromosomes", "breaks", "mutagenesis", "when", "it", "enters", "the", "DNA", "double", "helix", "."], "h": {"id": "C0020207", "name": "C0020207#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036329", "name": "C0036329#ent", "pos": [10, 11]}}
{"token": ["In", "cattle", ",", "the", "C0003805#ent", "<e1>", "locus", "comprises", "the", "aromatase", "cytochrome", "P450-encoding", "gene", "C0003805#ent", "<e1>", ")", "and", "a", "C1334043#ent", "<e1>", "CYP19P1", ")", "."], "h": {"id": "C0003805", "name": "C0003805#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["In", "three", "patients", ",", "the", "first", "manifestation", "of", "C0019202#ent", "<e1>", "a", "syndrome", "in", "which", "acute", "intravascular", "hemolysis", "C0085605#ent", "<e2>", "associated."], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [17, 18]}}
{"token": ["The", "method", "allowed", "us", "to", "establish", "the", "diagnosis", "of", "C0019202#ent", "<e1>", "24", "h", "in", "a", "patient", "with", "C0085605#ent", "<e2>"], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [17, 18]}}
{"token": ["To", "characterize", "C0019202#ent", "<e1>", "children", ",", "outline", "clinical", "and", "biochemical", "differences", "to", "fulminant", "C0085605#ent", "<e2>", "other", "etiologies", ",", "and", "compare", "sensitivity", "and", "specificity", "in", "diagnosing", "C0019202#ent", "<e1>", "alkaline", "phosphatase", "total", "bilirubin", "ratio", "aspartate", "aminotransferase", "alanine", "aminotransferase", "ratio"], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [13, 14]}}
{"token": ["C0149745#ent", "<e1>", "healed", "completely", "in", "15", "patients", "on", "C0031978#ent", "<e2>", "and", "21", "patients", "on", "cimetidine", "(", "chi-square", "test", ";", "P", "less", "than", "0.1", ")", ";", "this", "difference", "was", "not", "significant", "."], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [8, 9]}}
{"token": ["Four", "C0032708#ent", "<e1>", "patients", "exhibited", "no", "clinical", "evidence", "disease", "activation", "exposure", "to", "C1254351#ent", "<e2>", "."], "h": {"id": "C0032708", "name": "C0032708#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["4", "The", "effect", "of", "C0246569#ent", "<e1>", "was", "also", "selective", "for", "the", "IKK/NFkappaB", "signalling", "axis", ";", "C1417826#ent", "<e2>", "coupling", "to", "ERK", ",", "or", "p38", "MAP", "kinase", "unaffected", "."], "h": {"id": "C0246569", "name": "C0246569#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417826", "name": "C1417826#ent", "pos": [15, 16]}}
{"token": ["While", "a", "heat", "stable", "C0031667#ent", "<e1>", "predominantly", "increased", "in", "ascitic", "fluid", "the", "elevations", "of", "both", "heat", "stable", "and", "labile", "C0031667#ent", "<e1>", "activities", "in", "serum", "were", "observed", "in", "C1415587#ent", "<e1>", "induced", "pancreatitis", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415587", "name": "C1415587#ent", "pos": [27, 28]}}
{"token": ["Groups", "of", "ovariectomized", "(", "OVX", ")", "rats", "were", "treated", "with", "vehicle", "alone", ",", "C2936882#ent", "<e1>", ",", "or", "the", "diphosphonates", "etidronate", "or", "C0166025#ent", "<e2>", "for", "a", "180-day", "period", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0166025", "name": "C0166025#ent", "pos": [21, 22]}}
{"token": ["We", "have", "characterized", "C1421309#ent", "<e1>", "and", "identified", "candidates", "of", "endogenous", "substrates", "as", "well", "as", "C1423524#ent", "<e2>", "C1421309#ent", "<e1>", "."], "h": {"id": "C1421309", "name": "C1421309#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423524", "name": "C1423524#ent", "pos": [14, 15]}}
{"token": ["Studies", "with", "cloned", "GPX1", ",", "C1415276#ent", "<e1>", ",", "and", "GPX3", "expressed", "heterologously", "in", "Escherichia", "coli", "that", "these", "C1417679#ent", "<e2>", "encode", "proteins", "with", "PHGPx", "activity", "."], "h": {"id": "C1415276", "name": "C1415276#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["Again", ",", "we", "found", "similar", "rates", "of", "C1424987#ent", "<e1>", "repair", "in", "both", "strands", "of", "the", "C1366623#ent", "<e2>", "both", "APRT", "promoter-deletion", "mutants", "and", "their", "parental", "cell", "line"], "h": {"id": "C1424987", "name": "C1424987#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366623", "name": "C1366623#ent", "pos": [15, 16]}}
{"token": ["We", "show", "that", "an", "AP-1-dependent", "regulatory", "element", "dnmt1", "is", "heavily", "methylated", "in", "most", "somatic", "tissues", "and", "in", "the", "mouse", "embryonal", "cell", "line", "C1423526#ent", "<e1>", ",", "and", "completely", "unmethylated", "in", "a", "mouse", "adrenal", "carcinoma", "cell", "line", "C1419589#ent", "<e2>", "."], "h": {"id": "C1423526", "name": "C1423526#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1419589", "name": "C1419589#ent", "pos": [35, 36]}}
{"token": ["For", "all", "C0149678#ent", "<e1>", "clones", "the", "C1420224#ent", "<e2>", "and", "VK", "utilization", "was", "similar", "to", "that", "of", "the", "normal", "untransformed", "population", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420224", "name": "C1420224#ent", "pos": [6, 7]}}
{"token": ["Electrophoretic", "detection", "HGPI", "proteins", "inhibition", "of", "HGP", "isoforms", "by", "few", "pigeonpea", "wild", "relative", "C3273483#ent", "<e1>", "supported", "our", "C1333403#ent", "<e2>", "results", "."], "h": {"id": "C3273483", "name": "C3273483#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333403", "name": "C1333403#ent", "pos": [17, 18]}}
{"token": ["In", "conclusion", ",", "artemether", "proves", "to", "be", "effective", "against", "multiple", "drug", "resistant", "C0024535#ent", "<e1>", "malaria", "(", "including", "C0282398#ent", "<e2>", "strains", ")", "and", "can", "be", "considered", "as", "an", "alternative", "antimalarial", "to", "mefloquine", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [12, 13]}, "relation": "may_be_prevented_by", "t": {"id": "C0282398", "name": "C0282398#ent", "pos": [17, 18]}}
{"token": ["The", "therapy", "of", "benign", "malaria", "is", "still", "chloroquine", "plus", "primaquine", ";", "most", "patients", "with", "C0024535#ent", "<e1>", "be", "routinely", "treated", "with", "C0282398#ent", "<e2>", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [14, 15]}, "relation": "may_be_prevented_by", "t": {"id": "C0282398", "name": "C0282398#ent", "pos": [20, 21]}}
{"token": ["The", "epidemiological", "efficacy", "0.02", "per", "cent", "solution", "of", "prodigiosan", ",", "a", "bacterial", "polysaccharide", "used", "for", "the", "treatment", "of", "children", "in", "an", "area", "with", "C0035243#ent", "<e1>", "such", "as", "influenza", "and", "C0030389#ent", "<e2>", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0030389", "name": "C0030389#ent", "pos": [29, 30]}}
{"token": ["What", "we", "know", ":", "C0035243#ent", "<e1>", "by", "rhinoviruses", ",", "coronaviruses", ",", "influenza", ",", "C0030389#ent", "<e2>", "and", "respiratory", "syncytial", "viruses", "RSVs", ")", "are", "important", "triggers", "of", "asthma", "attacks"], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030389", "name": "C0030389#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "show", "that", "the", "first", "intron", "of", "the", "mouse", "C0124604#ent", "<e1>", "gene", "contains", "an", "uninterrupted", "C1412821#ent", "<e2>"], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "we", "show", "that", "the", "first", "intron", "of", "the", "rat", "C0124604#ent", "<e1>", "gene", "contains", "an", "C1412821#ent", "<e2>", "encodes", "a", "potential", "vesicular", "acetylcholine", "transporter", "on", "the", "following", "criteria", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [16, 17]}}
{"token": ["A", "37-year-old", "man", "with", "C0339143#ent", "<e1>", "underwent", "resection", "of", "the", "C0034543#ent", "<e2>", "general", "anesthesia"], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034543", "name": "C0034543#ent", "pos": [10, 11]}}
{"token": ["On", "the", "inter-specific", "backcross", "analyses", ",", "mouse", "Hes2", "is", "mapped", "to", "the", "distal", "region", "Chromosome", "4", "near", "Hes3", "and", "C2827373#ent", "<e1>", "loci", ",", "which", "are", "different", "from", "the", "C1412958#ent", "<e2>", "locus", "on", "Chromosome", "16"], "h": {"id": "C2827373", "name": "C2827373#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412958", "name": "C1412958#ent", "pos": [28, 29]}}
{"token": ["We", "find", "that", "both", "C1412958#ent", "<e1>", "and", "C2827373#ent", "<e2>", "are", "expressed", "by", "GRPs", "and", "that", "C1412958#ent", "<e1>", "can", "drive", "GRPs", "to", "an", "astrocyte", "cell", "fate", "the", "expense", "of", "oligodendrocyte", "differentiation", "."], "h": {"id": "C2827373", "name": "C2827373#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412958", "name": "C1412958#ent", "pos": [4, 5]}}
{"token": ["C2827373#ent", "<e1>", "synergizes", "with", "C1412958#ent", "<e2>", "and", "regulates", "neurogenesis", "at", "the", "level", "of", "Ngn1", "expression", "."], "h": {"id": "C2827373", "name": "C2827373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412958", "name": "C1412958#ent", "pos": [4, 5]}}
{"token": ["A", "late-onset", "C0031117#ent", "<e1>", "a", "mouse", "with", "a", "wider", "progressive", "C0027765#ent", "<e2>", "morphologically", "characterized", "for", "comparison", "with", "late", "life", "human", "neuropathies", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [10, 11]}}
{"token": ["Osteogenesis", "imperfecta", "OI", ")", "is", "clinically", "characterized", "by", "abnormal", "bone", "fragility", "with", "most", "patients", "harboring", "heterozygote", "germline", "mutations", "the", "C1332772#ent", "<e1>", "or", "COL1A2", "genes", "encode", "the", "chains", "of", "C1332773#ent", "<e2>", "the", "major", "protein", "in", "bone", "."], "h": {"id": "C1332772", "name": "C1332772#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1332773", "name": "C1332773#ent", "pos": [28, 29]}}
{"token": ["Here", "we", "show", "that", "the", "E4", "-", "6/7", "protein", "can", "functionally", "compensate", "for", "C1709313#ent", "<e1>", "expression", "in", "C0042769#ent", "<e2>"], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [17, 18]}}
{"token": ["The", "function", "of", "the", "adenovirus", "E1Aa", "protein", "the", "product", "of", "the", "13S", "C1709313#ent", "<e1>", "mRNA", ")", "during", "a", "productive", "C0042769#ent", "<e2>", "to", "activate", "transcription", "of", "the", "six", "early", "viral", "transcription", "units"], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "HBx", "and", "C1709313#ent", "<e1>", "activate", "transcription", "by", "a", "similar", "mechanism", "and", "that", "this", "C0042769#ent", "<e2>", "be", "useful", "for", "characterization", "of", "the", "functional", "activities", "of", "HBx", "."], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [17, 18]}}
{"token": ["Amongst", "166", "patients", "with", "aneurysms", ",", "ectasia", "or", "megaloarteries", "shown", "on", "coronary", "angiograms", "86.1", "%", "had", "dilated", "vessels", "part", "of", "C0017327#ent", "<e1>", "usually", "in", "patients", "with", "C3272265#ent", "<e2>", "."], "h": {"id": "C0017327", "name": "C0017327#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3272265", "name": "C3272265#ent", "pos": [26, 27]}}
{"token": ["To", "investigate", "the", "effects", "of", "(", "C0383779#ent", "<e1>", ")", ",", "a", "broad", "caspase", "inhibitor", "on", "allergic", "contact", "dermatitis", "C1275685#ent", "<e2>", ")", "."], "h": {"id": "C0383779", "name": "C0383779#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1275685", "name": "C1275685#ent", "pos": [18, 19]}}
{"token": ["Our", "interpretation", "is", "that", "divalent", "cations", "stimulate", "electron", "transfer", "NADPH-P450", "reductase", "several", "acceptors", "and", "that", "substrates", "and", "C1539600#ent", "<e1>", "can", "bind", "to", "C1142644#ent", "<e2>", "influence", "its", "rate", "of", "reduction", "by", "the", "reductase", "."], "h": {"id": "C1539600", "name": "C1539600#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [22, 23]}}
{"token": ["Predisposing", "factors", "the", "development", "of", "C0026718#ent", "<e1>", "are", "nonspecific", "and", "include", "hyperglycemia", ",", "hematologic", "malignancies", "C0027947#ent", "<e2>", ",", "pharmacologic", "immunosuppression", "solid", "organ", "bone", "marrow/stem", "cell", "transplantation", "burns", ",", "trauma", ",", "malnutrition", ",", "and", "intravenous", "drug", "use"], "h": {"id": "C0026718", "name": "C0026718#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "C0022614#ent", "<e1>", "antagonists", "blocked", "both", "learned", "and", "unlearned", "tolerance", "to", "C0008188#ent", "<e2>", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [12, 13]}}
{"token": ["Phencyclidine", "and", "dizocilpine", "produce", "dose-related", "substitution", "for", "ethanol", "as", "did", "the", "competitive", "C0022614#ent", "<e1>", "antagonist", ",", "CGS", "19755", "and", "the", "benzodiazepines", ",", "triazolam", "and", "C0008188#ent", "<e2>", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [24, 25]}}
{"token": ["A", "hexameric", "model", "of", "ClpX", "suggests", "that", "six", "C0030956#ent", "<e1>", "make", "hydrophobic", "contacts", "the", "hydrophobic", "clefts", "of", "the", "C1413504#ent", "<e2>", "heptmer", "asymmetrically", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413504", "name": "C1413504#ent", "pos": [18, 19]}}
{"token": ["Urinanalysis", "revealed", "red", "cells", "92", "%", "of", "C1456865#ent", "<e1>", "with", "26", "%", "in", "C0003615#ent", "<e2>", "."], "h": {"id": "C1456865", "name": "C1456865#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003615", "name": "C0003615#ent", "pos": [13, 14]}}
{"token": ["TRAIL-mediated", "apoptosis", "in", "C0074202#ent", "<e1>", "knocked-down", "cells", "was", "associated", "with", "C0010656#ent", "<e2>", "Bid", "cleavage", "and", "Mcl-1", "degradation", "."], "h": {"id": "C0074202", "name": "C0074202#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [10, 11]}}
{"token": ["Human", "C0067685#ent", "<e1>", "GCPII", ")", "is", "a", "C1366499#ent", "<e2>", "mainly", "in", "the", "brain", ",", "small", "intestine", "and", "prostate", "."], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1366499", "name": "C1366499#ent", "pos": [7, 8]}}
{"token": ["A", "CD30", "ligand", "C3889999#ent", "<e1>", ",", "CD153", ")", "is", "a", "C3540465#ent", "<e2>", "to", "the", "TNF", "family", "."], "h": {"id": "C3889999", "name": "C3889999#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540465", "name": "C3540465#ent", "pos": [10, 11]}}
{"token": ["A", "CD30-ligand", "(", "C3889999#ent", "<e1>", ")", "is", "a", "40-kilodalton", ",", "C3540465#ent", "<e2>", "to", "the", "tumor", "necrosis", "factor", "family"], "h": {"id": "C3889999", "name": "C3889999#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540465", "name": "C3540465#ent", "pos": [10, 11]}}
{"token": ["C3542501#ent", "<e1>", "been", "associated", "with", "membranous", "and", "C0017668#ent", "<e2>"], "h": {"id": "C3542501", "name": "C3542501#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [7, 8]}}
{"token": ["This", "unique", ",", "naturally", "occurring", "animal", "model", "C1318520#ent", "<e1>", "prove", "useful", "for", "investigating", "novel", "therapeutic", "interventions", "the", "treatment", "of", "C1318520#ent", "<e1>", "may", "yield", "insight", "into", "the", "immunopathology", "and", "etiology", "of", "C0026691#ent", "<e1>", "."], "h": {"id": "C1318520", "name": "C1318520#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [30, 31]}}
{"token": ["Lentiviral", "vectors", "the", "enhanced", "green", "fluorescence", "protein", "EGFP", ")", "transgene", "driven", "by", "either", "the", "cytomegalovirus", "or", "the", "elongation", "factor-1alpha", "promoter", ",", "but", "not", "the", "C1418508#ent", "<e1>", "directed", "high-level", "EGFP", "expression", "in", "C0669365#ent", "<e2>", "and", "smooth", "muscle", "cells"], "h": {"id": "C1418508", "name": "C1418508#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [31, 32]}}
{"token": ["In", "summary", ",", "C2936882#ent", "<e1>", ",", "via", "ERalpha", ",", "up-regulated", "hepatic", "expression", "C1426207#ent", "<e2>", "and", "-3", ",", "probably", "through", "transcriptional", "activation"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1426207", "name": "C1426207#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "the", "relationship", "between", "the", "height", "of", "macular", "detachment", "and", "visual", "recovery", "after", "treatment", "of", "C0035305#ent", "<e1>", "RDs", ")", "of", "<", "or", "=", "7", "days", "'", "C2926735#ent", "<e2>", "."], "h": {"id": "C0035305", "name": "C0035305#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [27, 28]}}
{"token": ["Gram", "stains", "the", "transtracheal", "aspirate", "rapid", ",", "accurate", "delineation", "of", "the", "etiologic", "C0032302#ent", "<e1>", "and", "were", "particularly", "valuable", "in", "indicating", "mixed", "C0004623#ent", "<e2>"], "h": {"id": "C0032302", "name": "C0032302#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [21, 22]}}
{"token": ["This", "case", "indicates", "that", "a", "C0032302#ent", "<e1>", "influenza", "A", "virus", "by", "a", "C0004623#ent", "<e2>", "S.", "aureus", "run", "a", "fatal", "course", "even", "in", "a", "vaccinated", "child", "."], "h": {"id": "C0032302", "name": "C0032302#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [12, 13]}}
{"token": ["Using", "human", "tumor", "cell", "lines", "of", "C1136197#ent", "<e1>", "enzymatic", "activity", "we", "have", "previously", "identified", "a", "single", "nucleotide", "polymorphism", "C1136197#ent", "<e1>", "*", "2", "allele", ")", "in", "the", "human", "C0919428#ent", "<e1>"], "h": {"id": "C1136197", "name": "C1136197#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919428", "name": "C0919428#ent", "pos": [27, 28]}}
{"token": ["Characteristics", "of", "DT", "diaphorase", "NAD(P)H", ":", "(", "C1136197#ent", "<e1>", "C0919428#ent", "<e2>", ")", "activity", "in", "Ictalurus", "punctatus", "the", "effect", "of", "C0919428#ent", "<e2>", "activity", "on", "menadione", "(MND)-mediated", "reduction", "of", "acetylated", "cytochrome", "c", "AcC", ")", "were", "examined", "."], "h": {"id": "C1136197", "name": "C1136197#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919428", "name": "C0919428#ent", "pos": [9, 10]}}
{"token": ["Both", "C1366477#ent", "<e1>", "and", "LPL", "showed", "significant", "C1423716#ent", "<e2>", "cytotoxic", "responses", ",", "although", "higher", "levels", "were", "detected", "in", "PBL", "."], "h": {"id": "C1366477", "name": "C1366477#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1423716", "name": "C1423716#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "NT-proBNP", "and", "CRP", "may", "be", "markers", "of", "mechanisms", "of", "C0019099#ent", "<e1>", "pathogenesis", "distinct", "from", "those", "responsive", "to", "C0003015#ent", "<e2>"], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [19, 20]}}
{"token": ["The", "accurate", "diagnosis", "of", "mild", "C0019099#ent", "<e1>", "became", "imperative", "with", "the", "advent", "of", "C0003015#ent", "<e2>"], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [13, 14]}}
{"token": ["In", "patients", "with", "C0042974#ent", "<e1>", "levels", "of", "C2732002#ent", "<e2>", "and", "FVIIICAG", "were", "in", "good", "agreement", ",", "both", "before", "and", "after", "treatment", "with", "cryoprecipitate", "or", "DDAVP", "."], "h": {"id": "C0042974", "name": "C0042974#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C2732002", "name": "C2732002#ent", "pos": [7, 8]}}
{"token": ["A", "common", "feature", "of", "C1412502#ent", "<e1>", "and", "other", "chronic", "lung", "diseases", "C0037036#ent", "<e2>", "of", "mucus", "into", "the", "airways", ",", "causing", "peripheral", "airway", "plugging", "and", "further", "airflow", "obstruction", "."], "h": {"id": "C1412502", "name": "C1412502#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037036", "name": "C0037036#ent", "pos": [11, 12]}}
{"token": ["IKs", ",", "an", "important", "repolarizing", "current", "in", "heart", ",", "is", "an", "C0003195#ent", "<e1>", "target", "and", "is", "markedly", "increased", "by", "activation", "of", "C0033640#ent", "<e2>", "PKA", ";", "eg", ",", "by", "beta-adrenergic", "stimulation", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [21, 22]}}
{"token": ["Notably", ",", "ARF", "binds", "C1334894#ent", "<e1>", "through", "the", "same", "domains", "that", "mediate", "nucleolar", "localization", "C0812222#ent", "<e2>", "binding", ",", "suggesting", "that", "C1334894#ent", "<e1>", "could", "control", "ARF", "localization", "and", "compete", "with", "C0812222#ent", "<e2>", "for", "ARF", "association", "."], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [14, 15]}}
{"token": ["Nearly", "51,000", "Cubans", "were", "afflicted", "during", "an", "outbreak", "of", "an", "C3887709#ent", "<e1>", "ON", ")", "and", "C0235025#ent", "<e2>", "PN", ")", "between", "1991", "and", "1993", "."], "h": {"id": "C3887709", "name": "C3887709#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [15, 16]}}
{"token": ["These", "disappeared", "after", "suppression", "of", "the", "VP", "allergy", "but", "the", "C1415975#ent", "<e1>", "response", "to", "C1706109#ent", "<e2>", "persisted", "until", "the", "cat", "was", "removed", "from", "the", "environment", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706109", "name": "C1706109#ent", "pos": [14, 15]}}
{"token": ["Recent", "studies", "have", "linked", "the", "increased", "frequency", "of", "polymorphism", "of", "methylenetetrahydrofolate", "reductase", "MTHFR", ",", "C677", "T", ")", "and", "C3713294#ent", "<e1>", "MTRR", ",", "A66", "G", ")", "in", "mothers", "with", "C0012772#ent", "<e2>", "child", "."], "h": {"id": "C3713294", "name": "C3713294#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0012772", "name": "C0012772#ent", "pos": [28, 29]}}
{"token": ["In", "conclusion", ",", "our", "results", "provide", "evidences", "that", "homocysteine", "and", "C3713294#ent", "<e1>", "genetic", "polymorphism", "two", "potent", "risk", "factors", "mothers", "to", "have", "a", "C0012772#ent", "<e2>", "child", "in", "Sicily", "."], "h": {"id": "C3713294", "name": "C3713294#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012772", "name": "C0012772#ent", "pos": [22, 23]}}
{"token": ["The", "relative", "activities", "adrenaline", ",", "noradrenaline", "and", "C0022245#ent", "<e1>", "in", "producing", "C0020456#ent", "<e2>", ",", "hyperinsulinaemia", "and", "glycogenolysis", "in", "liver", "and", "skeletal", "muscle", "been", "studied", "in", "both", "fed", "and", "fasted", "rats", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [11, 12]}}
{"token": ["C3538858#ent", "<e1>", "was", "map-based", "cloned", "and", "found", "to", "encode", "a", "C1420038#ent", "<e2>", "C3538858#ent", "<e1>", ")", "involved", "in", "the", "photorespiratory", "pathway", "."], "h": {"id": "C3538858", "name": "C3538858#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420038", "name": "C1420038#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "the", "kidney", "and", "placenta", "had", "high", "C3538858#ent", "<e1>", "and", "steady", "low", "C1420038#ent", "<e2>", "activity", "throughout", "gestation", "."], "h": {"id": "C3538858", "name": "C3538858#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420038", "name": "C1420038#ent", "pos": [14, 15]}}
{"token": ["We", "first", "assessed", "the", "ability", "of", "C1313616#ent", "<e1>", ",", "compared", "to", "tamoxifen", "and", "C0244404#ent", "<e2>", ",", "to", "prevent", "dimethylbenzanthracene", "(DMBA)-induced", "mammary", "tumors", "female", "Sencar", "mice"], "h": {"id": "C1313616", "name": "C1313616#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0244404", "name": "C0244404#ent", "pos": [13, 14]}}
{"token": ["There", "have", "been", "no", "head-to-head", "comparisons", "of", "valdecoxib", "and", "celecoxib", "or", "C0762662#ent", "<e1>", "in", "the", "treatment", "of", "C0029408#ent", "<e2>", ",", "rheumatoid", "arthritis", "or", "various", "pain", "conditions"], "h": {"id": "C0762662", "name": "C0762662#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "the", "safety", "profile", "of", "C0762662#ent", "<e1>", ",", "a", "selective", "cyclo-oxygenase-2", "inhibitor", "in", "patients", "with", "C0029408#ent", "<e2>", "who", "are", "receiving", "care", "in", "non-hospital", "practice", "settings", "."], "h": {"id": "C0762662", "name": "C0762662#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [16, 17]}}
{"token": ["Recent", "studies", "have", "established", "the", "usefulness", "and", "good", "tolerability", "of", "intranasal", "budesonide", "the", "treatment", "of", "seasonal", "allergic", "C0035457#ent", "<e1>", "the", "drug", "is", "more", "effective", "than", "C0012694#ent", "<e2>", "at", "least", "as", "effective", "as", "beclomethasone", "dipropionate"], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [25, 26]}}
{"token": ["The", "influence", "of", "Chlordiazepoxide", "(", "C0013881#ent", "<e1>", ")", "on", "the", "anticoagulating", "activity", "Phenprocoumon", "(", "C1706474#ent", "<e2>", ")", "was", "investigated", "in", "rats", "."], "h": {"id": "C0013881", "name": "C0013881#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706474", "name": "C1706474#ent", "pos": [14, 15]}}
{"token": ["We", "now", "describe", "an", "alpha-N-acetylglucosaminyl", "phosphodiesterase", "rat", "C0023899#ent", "<e1>", "that", "is", "capable", "of", "removing", "the", "N-acetyl-glucosamine", "residues", "leaving", "C0001109#ent", "<e2>", "groups", "on", "the", "high", "mannose", "oligosaccharide", "units"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001109", "name": "C0001109#ent", "pos": [18, 19]}}
{"token": ["We", "also", "show", "that", "the", "exogenously", "applied", "C0036734#ent", "<e1>", "plasmin", ",", "and", "C0032143#ent", "<e2>", "activate", "PAR1", "signaling", "brain", "tissue"], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [12, 13]}}
{"token": ["Other", "C0747256#ent", "<e1>", "have", "rarely", "been", "associated", "with", "pleural", "disease", "pneumocystosis", ",", "Loeffler's", "syndrome", "tropical", "pulmonary", "eosinophilia", "C0040553#ent", "<e2>", ",", "anisakiasis", ",", "hypodermiasis", ",", "strongyloidiasis", ",", "and", "schistosomiasis", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0040553", "name": "C0040553#ent", "pos": [17, 18]}}
{"token": ["Exposure", "of", "the", "plasmid", "pBR", "322", "to", "the", "C1421531#ent", "<e1>", "single", "strand", "scissions", "and", "C0014230#ent", "<e2>", "III-sensitive", "sites", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014230", "name": "C0014230#ent", "pos": [14, 15]}}
{"token": ["A", "randomised", "double", "blind", "placebo", "controlled", "trial", "of", "treatment", "with", "an", "aerosolised", "C0003451#ent", "<e1>", "ribavirin", ",", "was", "conducted", "in", "26", "infants", "with", "clinically", "diagnosed", "C0006271#ent", "<e2>", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006271", "name": "C0006271#ent", "pos": [24, 25]}}
{"token": ["Specific", "examination", "of", "the", "role", "of", "C1705952#ent", "<e1>", "in", "C1704824#ent", "<e2>", "oncogene-driven", "mammary", "epithelial", "cancer", "revealed", "no", "critical", "role", "for", "C1705952#ent", "<e1>", "despite", "the", "inherent", "C1705952#ent", "<e1>", "sensitivity", "of", "such", "mammary", "carcinomas"], "h": {"id": "C1704824", "name": "C1704824#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705952", "name": "C1705952#ent", "pos": [6, 7]}}
{"token": ["The", "plasma", "C1418938#ent", "<e1>", "level", "increased", "significantly", "at", "45", "and", "60", "min", "after", "C0000503#ent", "<e2>", "injection", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000503", "name": "C0000503#ent", "pos": [13, 14]}}
{"token": ["C0272302#ent", "<e1>", "GPS", ")", "is", "a", "disorder", "characterized", "by", "C0040034#ent", "<e2>", "and", "large", "platelets", "that", "lack", "alpha", "granules", "their", "contents", "."], "h": {"id": "C0272302", "name": "C0272302#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [9, 10]}}
{"token": ["By", "immunohistochemistry", "tumor", "cells", "positive", "for", "vimentin", ",", "muscle-specific", "actin", "desmin", ",", "C2986638#ent", "<e1>", ",", "and", "Myo-D1", "with", "focal", "positivity", "for", "C1334863#ent", "<e2>", ",", "neuron-specific", "enolase", "and", "S-100", "protein"], "h": {"id": "C2986638", "name": "C2986638#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [21, 22]}}
{"token": ["We", "tested", "the", "effects", "of", "tissue", "plasminogen", "activator", "t-PA", ")", "with", "the", "glutamate", "antagonist", "MK-801", "or", "the", "C0006684#ent", "<e1>", "nimodipine", "in", "an", "C0262469#ent", "<e2>", "model", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0262469", "name": "C0262469#ent", "pos": [22, 23]}}
{"token": ["Cells", "were", "exposed", "to", "C0013227#ent", "<e1>", "via", "filter", "paper", "discs", "on", "the", "C0026818#ent", "<e2>", "surface", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [12, 13]}}
{"token": ["Prenatal", "administration", "C0013227#ent", "<e1>", "revealed", "no", "significant", "alteration", "in", "the", "binding", "of", "C0026818#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [12, 13]}}
{"token": ["C0005716#ent", "<e1>", "is", "a", "rare", ",", "C0948382#ent", "<e2>", "mostly", "in", "tropical", "and", "subtropical", "regions", "."], "h": {"id": "C0005716", "name": "C0005716#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0948382", "name": "C0948382#ent", "pos": [6, 7]}}
{"token": ["Although", "the", "immunostaining", "intensity", "for", "the", "two", "C3541394#ent", "<e1>", "was", "similar", "at", "pallidal", "level", ",", "that", "for", "C1414926#ent", "<e2>", "was", "more", "intense", "than", "that", "for", "GAD67", "at", "the", "striatal", "level"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414926", "name": "C1414926#ent", "pos": [17, 18]}}
{"token": ["A", "quantum", "chemical", "C1706237#ent", "<e1>", ")", "combined", "with", "a", "classical", "study", "of", "structure-activity", "relationships", "C0012315#ent", "<e2>", "(", "nifedipine", "analogues", ")", "was", "performed", "."], "h": {"id": "C1706237", "name": "C1706237#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [14, 15]}}
{"token": ["Rats", "received", "anti-NGF", "on", "postnatal", "days", "PNDs", ")", "2", "-", "12", ",", "and", "C0008407#ent", "<e1>", "ChAT", ")", "activity", "was", "measured", "on", "C1956415#ent", "<e2>", "16", "."], "h": {"id": "C0008407", "name": "C0008407#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1956415", "name": "C1956415#ent", "pos": [21, 22]}}
{"token": ["The", "C0003289#ent", "<e1>", "effects", "of", "citrate", "and", "C1412179#ent", "<e2>", "on", "tension", "were", "greater", "at", "pH", "5.5", "-", "6", "and", "C1412179#ent", "<e2>", "had", "no", "effect", "pH", "8.5", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [7, 8]}}
{"token": ["4", ")", "The", "C0003289#ent", "<e1>", "action", "of", "theophylline", "was", "masked", "by", "the", "addition", "of", "C1412179#ent", "<e2>", "the", "hyperosmotic", "Ringer", "'s", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [14, 15]}}
{"token": ["Thus", "the", "C0003289#ent", "<e1>", "effect", "is", "stronger", "with", "more", "protonated", "forms", "citrate", "and", "C1412179#ent", "<e2>", ",", "which", "are", "also", "poorer", "Ca", "buffers"], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [13, 14]}}
{"token": ["Nonsteroidal", "antiinflammatory", "drugs", "C0080151#ent", "<e1>", ")", "have", "been", "applied", "topically", "to", "reduce", "C0151827#ent", "<e2>", "by", "corneal", "injury", "anterior", "segment", "surgery", "."], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0151827", "name": "C0151827#ent", "pos": [12, 13]}}
{"token": ["Focal", "segmental", "glomerulosclerosis", "nephrotic", "syndrome", "C1561643#ent", "<e1>", "associated", "with", "spondyloepiphyseal", "dysplasia", "growth", "failure", "lymphopenia", "and", "transient", "C0745413#ent", "<e2>", "to", "severe", "neurological", "symptoms", "three", "children", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0745413", "name": "C0745413#ent", "pos": [16, 17]}}
{"token": ["While", "the", "AP-1", "site", "is", "involved", "in", "C1420295#ent", "<e1>", "expression", "of", "C3494976#ent", "<e2>", ",", "the", "presence", "of", "one", "or", "more", "AP-2", "elements", "appears", "critical", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [11, 12]}}
{"token": ["This", "proposed", "role", "would", "therefore", "be", "similar", "to", "the", "roles", "observed", "for", "BCR", "and", "C1333214#ent", "<e1>", "of", "the", "chimeric", "oncoproteins", "BCR-ABL", "and", "C3274602#ent", "<e2>", "in", "acute", "myeloid", "leukemia", "acute", "nonlymphocytic", "leukemia", "respectively", "."], "h": {"id": "C1333214", "name": "C1333214#ent", "pos": [14, 15]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274602", "name": "C3274602#ent", "pos": [22, 23]}}
{"token": ["The", "C0035220#ent", "<e1>", "RDS", ")", "model", "induced", "by", "C0028928#ent", "<e2>", "injection", "in", "dogs", "and", "treated", "by", "anisodamine", "were", "observed", "."], "h": {"id": "C0035220", "name": "C0035220#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [8, 9]}}
{"token": ["Expression", "of", "the", "dominant", "negative", "form", "of", "C1419407#ent", "<e1>", ",", "but", "not", "that", "of", "Ras", ",", "blocked", "forskolin-induced", "C1456380#ent", "<e2>", "activation", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [18, 19]}}
{"token": ["Protein", "4.1", "is", "a", "C1415740#ent", "<e1>", "a", "strategic", "position", "in", "the", "C1420193#ent", "<e2>"], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [11, 12]}}
{"token": ["C1414395#ent", "<e1>", "is", "a", "component", "of", "a", "high", "molecular", "weight", "endoplasmic", "reticulum", "membrane-bound", "protein", "complex", "including", "C1332803#ent", "<e2>", "."], "h": {"id": "C1414395", "name": "C1414395#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [16, 17]}}
{"token": ["Pathogenic", "C1414395#ent", "<e1>", "mutations", "were", "demonstrated", "to", "have", "an", "effect", "on", "C1332803#ent", "<e2>", "and", "glycogen", "synthase", "kinase-3beta(GSK-3beta", ",", "two", "members", "of", "the", "wingless", "Wnt", "pathway"], "h": {"id": "C1414395", "name": "C1414395#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [11, 12]}}
{"token": ["In", "21", "patients", "with", "C0039236#ent", "<e1>", "all", "the", "patients", "with", "atrial", "arrhythmias", "electrical", "stimulation", "C0282211#ent", "<e2>", "infusion", "produced", "the", "same", "tachycardia", "that", "had", "been", "seen", "during", "exercise", "testing", "Holter", "monitoring"], "h": {"id": "C0039236", "name": "C0039236#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [14, 15]}}
{"token": ["C0699171#ent", "<e1>", "(", "pyracetame", ")", "corrected", "the", "LDH", "isoenzyme", "spectra", "C0001614#ent", "<e2>", "14", "days", "old", "rats", "and", "in", "medulla", "oblongata", "30", "days", "old", "animals", "."], "h": {"id": "C0699171", "name": "C0699171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [10, 11]}}
{"token": ["Dysferlin", ",", "the", "protein", "product", "the", "gene", "mutated", "patients", "with", "an", "autosomal", "recessive", "limb-girdle", "muscular", "dystrophy", "type", "2B", "C2986625#ent", "<e1>", ")", "and", "a", "C0751336#ent", "<e2>", "Miyoshi", "myopathy", "is", "homologous", "to", "a", "Caenorhabditis", "elegans", "spermatogenesis", "factor", "FER-1", "."], "h": {"id": "C2986625", "name": "C2986625#ent", "pos": [18, 19]}, "relation": "gene_associated_with_disease", "t": {"id": "C0751336", "name": "C0751336#ent", "pos": [23, 24]}}
{"token": ["Both", "placebo-controlled", "and", "comparative", "studies", "other", "C0035064#ent", "<e1>", "have", "demonstrated", "C0257343#ent", "<e2>", "to", "be", "an", "effective", "treatment", "for", "patients", "with", "lower", "urinary", "symptoms", "of", "benign", "prostatic", "hyperplasia"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0257343", "name": "C0257343#ent", "pos": [10, 11]}}
{"token": ["C0162756#ent", "<e1>", "high", "doses", "metoclopramide", "in", "combination", "with", "C0040616#ent", "<e2>", "and", "steroids", "as", "well", "as", "greater", "attention", "to", "pharmacokinetic", "profiles", "the", "drugs", "involved", "would", "appear", "to", "offer", "improved", "control", "."], "h": {"id": "C0162756", "name": "C0162756#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040616", "name": "C0040616#ent", "pos": [8, 9]}}
{"token": ["In", "this", "study", "we", "demonstrated", "the", "presence", "of", "C0659268#ent", "<e1>", "KAT", ")", "I", "and", "C3273406#ent", "<e2>", "in", "the", "cytoplasm", "of", "bovine", "aortic", "endothelial", "cells", "BAEC", ")", "."], "h": {"id": "C0659268", "name": "C0659268#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [14, 15]}}
{"token": ["To", "treat", "C0003128#ent", "<e1>", "women", "with", "high", "plasma", "LH", "levels", "with", "C0077834#ent", "<e2>", "."], "h": {"id": "C0003128", "name": "C0003128#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0077834", "name": "C0077834#ent", "pos": [11, 12]}}
{"token": ["Pharmaceutical", "preparations", "containing", "C0002586#ent", "<e1>", ",", "noraminophenazonum", "sodium", "mesylicum", ",", "acidum", "acetylsalicylicum", "and", "aethylmorphinium", "C1154250#ent", "<e2>", "--", "official", "in", "the", "VI", "."], "h": {"id": "C0002586", "name": "C0002586#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1154250", "name": "C1154250#ent", "pos": [14, 15]}}
{"token": ["In", "dogs", ",", "the", "most", "common", "final", "diagnoses", "were", "C0029877#ent", "<e1>", ",", "pyoderma", ",", "anal", "sac", "impaction", "flea", "C0851341#ent", "<e2>", "and", "atopic", "dermatitis"], "h": {"id": "C0029877", "name": "C0029877#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0851341", "name": "C0851341#ent", "pos": [18, 19]}}
{"token": ["Anterior", "and", "C0042167#ent", "<e1>", "retinal", "vasculitis", "only", "have", "a", "prognostic", "value", "C0004943#ent", "<e2>", "in", "this", "particular", "case", "supported", "the", "diagnosis", "."], "h": {"id": "C0042167", "name": "C0042167#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [11, 12]}}
{"token": ["C0042167#ent", "<e1>", "the", "most", "severe", "manifestation", "of", "C0004943#ent", "<e2>", "as", "it", "can", "lead", "to", "residual", "permanent", "damage"], "h": {"id": "C0042167", "name": "C0042167#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [7, 8]}}
{"token": ["These", "flares", "are", "characterised", "by", "a", "fast", "and", "marked", "C1418888#ent", "<e1>", "(", "PG", ")", "depletion", "if", "compared", "with", "the", "initial", "C0029408#ent", "<e2>", "."], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [20, 21]}}
{"token": ["A", "comparison", "of", "the", "nucleotide", "and", "deduced", "amino", "acid", "sequences", "clones", "mag-1", "and", "C1332034#ent", "<e1>", "with", "sequences", "in", "available", "data", "bases", "no", "C4277608#ent", "<e2>", "."], "h": {"id": "C1332034", "name": "C1332034#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [22, 23]}}
{"token": ["Deep", "vein", "thrombosis", "DVT", ")", "and", "pulmonary", "embolism", "C1412446#ent", "<e1>", ")", "are", "common", "life", "threatening", "complications", "of", "C0037928#ent", "<e2>"], "h": {"id": "C1412446", "name": "C1412446#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037928", "name": "C0037928#ent", "pos": [17, 18]}}
{"token": ["Our", "understanding", "of", "the", "transcellular", "movement", "of", "Mg(2", "+", ")", "was", "similarly", "enhanced", "by", "the", "realization", "that", "defects", "in", "C1421171#ent", "<e1>", "TRPM6", ")", "cause", "hypomagnesemia", "with", "C0020598#ent", "<e2>"], "h": {"id": "C1421171", "name": "C1421171#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0020598", "name": "C0020598#ent", "pos": [26, 27]}}
{"token": ["Both", "C1705574#ent", "<e1>", "and", "HR", "required", "C1333909#ent", "<e2>", "+", "and", "thiol", "for", "enzymatic", "activity"], "h": {"id": "C1705574", "name": "C1705574#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [6, 7]}}
{"token": ["A", "model", "of", "the", "survival", "of", "the", "Swedish", "Alzheimer", "disease", "population", "constructed", "in", "which", "the", "placement", "of", "patients", "with", "C0002395#ent", "<e1>", "care", "organization", "assumed", "to", "be", "influenced", "by", "the", "use", "of", "C0039245#ent", "<e2>", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0039245", "name": "C0039245#ent", "pos": [31, 32]}}
{"token": ["The", "conditions", "treated", "were", ":", "plaque-type", "psoriasis", ",", "C0343055#ent", "<e1>", "endogenous", "eczema", "and", "persistent", "C0343055#ent", "<e1>"], "h": {"id": "C0343055", "name": "C0343055#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0343055", "name": "C0343055#ent", "pos": [8, 9]}}
{"token": ["These", "repeats", "consisted", "of", "(A)10", "in", "the", "TGF", "C0067533#ent", "<e1>", "(G)8", "in", "the", "BAX", ",", "(A)8", "in", "the", "C0534519#ent", "<e2>", ",", "and", "(CCA)7", "in", "the", "APP", "genes", "."], "h": {"id": "C0067533", "name": "C0067533#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [18, 19]}}
{"token": ["This", "study", "evaluates", "the", "combined", "effects", "of", "genetic", "polymorphisms", "GSTM1", ",", "GSTT1", ",", "and", "C0919451#ent", "<e1>", "on", "susceptibility", "to", "cervical", "cancer", "interaction", "of", "these", "C1417679#ent", "<e2>", "with", "smoking", "."], "h": {"id": "C0919451", "name": "C0919451#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["C0919451#ent", "<e1>", "and", "GSTM1", "are", "C1417679#ent", "<e2>", "involved", "in", "Phase", "II", "metabolism", "whereas", "p53", "is", "a", "tumor", "suppressor", "gene"], "h": {"id": "C0919451", "name": "C0919451#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}}
{"token": ["Furthermore", ",", "substitution", "of", "C1705438#ent", "<e1>", "CHR", "with", "the", "C0812291#ent", "<e2>", "CHR", "in", "the", "C1705438#ent", "<e1>", "promoter", "revealed", "that", "the", "C0812291#ent", "<e2>", "CHR", "was", "unable", "to", "repress", "the", "C1705438#ent", "<e1>", "promoter", "completely", "in", "the", "G0", "phase"], "h": {"id": "C1705438", "name": "C1705438#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812291", "name": "C0812291#ent", "pos": [9, 10]}}
{"token": ["Indeed", ",", "we", "found", "that", "EGFR", "co-immunoprecipitated", "with", "C1705438#ent", "<e1>", "in", "an", "EGF-dependent", "manner", "and", "that", "EGF", "activated", "in", "vivo", "binding", "of", "C1705438#ent", "<e1>", "to", "the", "C0812291#ent", "<e1>", "promoter", "."], "h": {"id": "C1705438", "name": "C1705438#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812291", "name": "C0812291#ent", "pos": [26, 27]}}
{"token": ["These", "included", "angiotensin-converting", "enzyme", "inhibitors", "hypertension", ",", "acarabose", "against", "C0011847#ent", "<e1>", ",", "and", "the", "antiplatelet", "agent", "C0077126#ent", "<e2>", "instead", "of", "aspirin", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0077126", "name": "C0077126#ent", "pos": [16, 17]}}
{"token": ["We", "suggest", "that", "the", "anti-cholinergic", "effects", "of", "C0012702#ent", "<e1>", "can", "induce", "MG", "crisis", "and", "should", "therefore", "be", "carefully", "considered", "when", "C0012702#ent", "<e1>", "is", "used", "to", "treat", "C0004238#ent", "<e1>", "in", "patients", "with", "MG", "."], "h": {"id": "C0012702", "name": "C0012702#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [26, 27]}}
{"token": ["Bacillus", "thuringiensis", "Bt", ")", "cyt", "genes", "hemolytic", "and", "cytolytic", "toxins", "constitute", "a", "C1517488#ent", "<e1>", "which", "are", "divided", "into", "two", "groups", ":", "C0152264#ent", "<e2>", "and", "cyt2", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0152264", "name": "C0152264#ent", "pos": [21, 22]}}
{"token": ["Having", "already", "shown", "positive", "effects", "of", "in", "long-standing", "C0011854#ent", "<e1>", "patients", ",", "we", "decided", "to", "try", "the", "association", "of", "C0017631#ent", "<e2>", "with", "insulin", "in", "newly", "diagnosed", "C0011854#ent", "<e1>", "patients", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017631", "name": "C0017631#ent", "pos": [19, 20]}}
{"token": ["A", "role", "for", "C1706544#ent", "<e1>", "in", "recruiting", "lymphocytes", "to", "the", "C4023110#ent", "<e2>", "also", "supported", "by", "the", "observation", "that", "lymphocytes", "preincubated", "with", "anti-LFA-1", "antibody", "did", "not", "bind", "to", "granulomas", "in", "tissue", "sections"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4023110", "name": "C4023110#ent", "pos": [10, 11]}}
{"token": ["An", "identical", "behavior", "in", "these", "experiments", "showed", "also", "C0699919#ent", "<e1>", "active", "site", "only", "had", "been", "C0033652#ent", "<e2>", ";", "these", "findings", "suggested", "the", "presence", "of", "one", "additional", "SH-group", "."], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033652", "name": "C0033652#ent", "pos": [15, 16]}}
{"token": ["The", "DNA", "sequence", "an", "open", "reading", "frame", "C0079941#ent", "<e1>", ")", "corresponding", "to", "the", "murine", "adenovirus", "type", "1", "Mav1", ")", "C1335528#ent", "<e2>", "determined", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335528", "name": "C1335528#ent", "pos": [19, 20]}}
{"token": ["All", "patients", "were", "Caucasians", "with", "C0019069#ent", "<e1>", "39", "to", "74", "years", "of", "age", ",", "and", "had", "C0023890#ent", "<e2>"], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [16, 17]}}
{"token": ["C2717971#ent", "<e1>", "in", "both", "inflammation", "and", "tumorigenesis", "through", "the", "activation", "of", "C1414506#ent", "<e2>", "PAR(2", ")", ")", ",", "which", "up-regulates", "COX-2", "by", "an", "unknown", "mechanism", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414506", "name": "C1414506#ent", "pos": [11, 12]}}
{"token": ["Recently", ",", "the", "role", "of", "C2717971#ent", "<e1>", "the", "pathogenesis", "of", "inflammation", "and", "autoimmune", "diseases", "interaction", "with", "the", "C1414506#ent", "<e2>", "PAR", ")", "has", "attracted", "attention", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414506", "name": "C1414506#ent", "pos": [17, 18]}}
{"token": ["Two", "major", "dust", "mite", "Ags", ",", "Der", "p3", "and", "Der", "p9", ",", "are", "C2717971#ent", "<e1>", "may", "activate", "lung", "epithelial", "cells", "interaction", "with", "the", "C1414506#ent", "<e2>", "PAR-2", ")", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414506", "name": "C1414506#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "the", "development", "of", "C0343055#ent", "<e1>", "a", "patient", "who", "took", "C0076110#ent", "<e2>"], "h": {"id": "C0343055", "name": "C0343055#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [11, 12]}}
{"token": ["Future", "studies", "should", "investigate", "if", "the", "involvement", "of", "the", "C0002707#ent", "<e1>", "is", "due", "to", "C1420620#ent", "<e2>", "or", "rather", "caused", "by", "the", "genetically-linked", "most", "frequent", "comorbidity", "ADHD", "."], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [14, 15]}}
{"token": ["A", "significant", "decrease", "in", "the", "left-hemispheric", "amygdalar", "volumes", "and", "in", "the", "proportions", "of", "C0002707#ent", "<e1>", "to", "total", "brain", "volumes", "observed", "in", "members", "of", "the", "C1420620#ent", "<e2>", "group", "compared", "with", "the", "comparison", "group", "."], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [24, 25]}}
{"token": ["In", "20", "%", "of", "the", "families", ",", "C0154723#ent", "<e1>", "is", "associated", "with", "permanent", "neurological", "signs", ",", "mainly", "nystagmus", "and", "C0007758#ent", "<e2>"], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [19, 20]}}
{"token": ["Biotype", "3", "strains", "also", "produced", "a", "single", "C0005244#ent", "<e1>", "with", "a", "pI", "of", "5.4", "-", "5.6", "corresponding", "to", "C0027203#ent", "<e2>", "the", "chromosomally", "mediated", "cephalosporinase", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["We", "reported", "here", "that", "both", "nucleotides", "strongly", "inhibit", "the", "activity", "of", "C1416427#ent", "<e1>", "adenylosuccinate", "synthetase", "the", "first", "C3540790#ent", "<e2>", "of", "the", "guanylate", "and", "adenylate", "biosynthetic", "pathways"], "h": {"id": "C1416427", "name": "C1416427#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [17, 18]}}
{"token": ["We", "developed", "a", "limited", "sampling", "strategy", "(", "C1416926#ent", "<e1>", ")", "for", "predicting", "C0010592#ent", "<e2>", "(", "Neoral", ")", "area", "under", "the", "curve", "from", "concentration-time", "data", "obtained", "specifically", "from", "lung", "transplant", "recipients", "."], "h": {"id": "C1416926", "name": "C1416926#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [12, 13]}}
{"token": ["Knowledge", "of", "a", "C0276275#ent", "<e1>", "implications", "for", "understanding", "the", "pathogenesis", "of", "C0205882#ent", "<e2>", "for", "the", "use", "of", "parvoviruses", "in", "gene", "therapy"], "h": {"id": "C0276275", "name": "C0276275#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0205882", "name": "C0205882#ent", "pos": [11, 12]}}
{"token": ["We", "present", "the", "first", "reported", "case", ",", "to", "our", "knowledge", ",", "of", "C0276275#ent", "<e1>", "B19-associated", "hemophagocytic", "syndrome", "in", "which", "the", "diagnosis", "of", "C0205882#ent", "<e2>", "documented", "by", "the", "presence", "of", "B19-specific", "IgM", "and", "IgG", "antibodies"], "h": {"id": "C0276275", "name": "C0276275#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0205882", "name": "C0205882#ent", "pos": [22, 23]}}
{"token": ["Filtrates", "from", "cultures", "of", "a", "psychrophilic", "Pseudomonas", "species", ",", "which", "inactivate", "C0162758#ent", "<e1>", "certain", "viral", "hemagglutinins", "were", "shown", "to", "contain", "both", "lecithinase", "(", "C0031671#ent", "<e2>", "and", "a", "proteolytic", "enzyme", "elastase", "activity"], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [23, 24]}}
{"token": ["Our", "studies", "identified", "C4277608#ent", "<e1>", "of", "SREBP", ",", "its", "binding", "partner", "C1822619#ent", "<e2>", ",", "and", "the", "ER", "retention", "protein", "Insig", "in", "Schizosaccharomyces", "pombe", "named", "sre1", "+", ",", "scp1", "+", ",", "and", "ins1", "+", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1822619", "name": "C1822619#ent", "pos": [11, 12]}}
{"token": ["In", "the", "malaria", "vector", "Anopheles", "gambiae", "tryptophan", "2,3-dioxygenase", "C1420674#ent", "<e1>", ")", "is", "the", "only", "enzyme", "able", "to", "initiate", "C0041260#ent", "<e2>", "degradation", "through", "the", "kynurenine", "pathway"], "h": {"id": "C1420674", "name": "C1420674#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0041260", "name": "C0041260#ent", "pos": [18, 19]}}
{"token": ["Based", "on", "the", "examples", "of", "lymphangioleiomyomatosis", "and", "C0034068#ent", "<e1>", "we", "emphasize", "the", "value", "of", "a", "global", "approach", "C0920627#ent", "<e2>", "the", "context", "of", "a", "medical", "specialty"], "h": {"id": "C0034068", "name": "C0034068#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0920627", "name": "C0920627#ent", "pos": [17, 18]}}
{"token": ["C1413234#ent", "<e1>", "is", "the", "murine", "C1334043#ent", "<e2>", "of", "the", "human", "macrophage", "glycoprotein", "CD68", "(", "72", "%", "identity", ",", "80", "%", "similarity", ")", "."], "h": {"id": "C1413234", "name": "C1413234#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}}
{"token": ["Cells", "were", "incubated", "with", "corticotropin-releasing", "hormone", "C1366535#ent", "<e1>", "forskolin", ",", "phorbol", "myristate", "acetate", "or", "C1421143#ent", "<e2>"], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [14, 15]}}
{"token": ["In", "urethane-anesthetized", "rats", ",", "injections", "of", "50", "pmol", "of", "C1366535#ent", "<e1>", "(", "AVP", ")", "or", "C1421143#ent", "<e2>", "TRH", ")", "into", "a", "lateral", "cerebral", "ventricle", "i.c.v", ".", ")"], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [15, 16]}}
{"token": ["Serum", "LH", "FSH", ",", "TSH", ",", "PRL", ",", "GH", ",", "and", "cortisol", "were", "measured", "in", "10", "patients", "with", "C1366535#ent", "<e1>", "basally", "and", "after", "a", "combined", "insulin-induced", "hypoglycemia", "LRH", "and", "C1421143#ent", "<e2>"], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [29, 30]}}
{"token": ["Lysyl", "oxidase", "activity", "inhibition", "using", "beta-aminoproprionitrile", "in", "a", "skin", "equivalent", "model", "prepared", "with", "both", "primary", "human", "keratinocytes", "and", "HaCaT", "cell", "line", "affected", "C1416714#ent", "<e1>", "filaggrin", "expression", "and", "disorganized", "the", "C0009325#ent", "<e2>", "network", "and", "the", "basement", "membrane"], "h": {"id": "C1416714", "name": "C1416714#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [29, 30]}}
{"token": ["However", ",", "postischemic", "responses", "of", "diabetic", "hearts", "C1832586#ent", "<e1>", ")", "to", "eicosanoids", "such", "as", "C0205911#ent", "<e2>", "are", "unknown", "."], "h": {"id": "C1832586", "name": "C1832586#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [14, 15]}}
{"token": ["C0086376#ent", "<e1>", "induced", "by", "C0053225#ent", "<e2>", "Escherichia", "coli", "observed", "on", "two-dimensional", "electrophoretic", "gels", "2-D", "gels", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0053225", "name": "C0053225#ent", "pos": [4, 5]}}
{"token": ["To", "study", "the", "induction", "of", "differentiation", "in", "human", "melanoma", "cells", "we", "treated", "12", "melanoma", "cell", "lines", "mycophenolic", "acid", "C0076656#ent", "<e1>", ",", "inhibitors", "of", "IMP", "dehydrogenase", "C1454821#ent", "<e2>", ")", "."], "h": {"id": "C0076656", "name": "C0076656#ent", "pos": [18, 19]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C1454821", "name": "C1454821#ent", "pos": [25, 26]}}
{"token": ["C0042164#ent", "<e1>", "pars", "planitis", "was", "the", "single", "most", "frequently", "diagnosed", "C1510449#ent", "<e2>", "entity", "and", "accounted", "for", "92", "cases", "(", "15.4", "%", ")", "."], "h": {"id": "C0042164", "name": "C0042164#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C1510449", "name": "C1510449#ent", "pos": [10, 11]}}
{"token": ["The", "introduction", "of", "the", "alpha-enolase", "protein", "the", "cells", "restores", "C1705556#ent", "<e1>", "levels", "and", "prevents", "cell", "death", "C0178540#ent", "<e2>", "reoxygenation", "in", "these", "cells", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0178540", "name": "C0178540#ent", "pos": [16, 17]}}
{"token": ["Five", "mutant", "cell", "lines", "CJ-1", "through", "CJ-5", ")", "were", "selected", "based", "on", "their", "failure", "to", "express", "a", "lethal", "diphtheria", "toxin", "A", "chain", "gene", "a", "C0022959#ent", "<e1>", "by", "NF-AT", ",", "a", "Ca(2+)-", "and", "protein", "kinase", "C1412615#ent", "<e2>"], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1412615", "name": "C1412615#ent", "pos": [34, 35]}}
{"token": ["Number", "of", "putatively", "preneoplastic", ",", "C0017837#ent", "<e1>", "liver", "lesions", "increased", "by", "C0009975#ent", "<e2>", "300", "ppm", "or", "greater", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009975", "name": "C0009975#ent", "pos": [11, 12]}}
{"token": ["Sodium", "valproate", "diazepam", ",", "C0041038#ent", "<e1>", ",", "and", "ethosuximide", "suppressed", "the", "spontaneous", "C0751495#ent", "<e2>", "and", "protected", "against", "PTZ-induced", "seizures", "in", "a", "dose-dependent", "fashion"], "h": {"id": "C0041038", "name": "C0041038#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [12, 13]}}
{"token": ["Similarly", ",", "the", "benzodiazepine", "midazolam", "the", "adenosine", "A1", "agonist", "2-chloroadenosine", ",", "but", "not", "antiepileptic", "drugs", "as", "phenobarbital", ",", "C0041038#ent", "<e1>", ",", "ethosuximide", ",", "or", "acetazolamide", ",", "showed", "a", "protective", "efficacy", "C0751495#ent", "<e2>", "."], "h": {"id": "C0041038", "name": "C0041038#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [30, 31]}}
{"token": ["All", "3", "compounds", "are", "anticonvulsants", "that", "modulate", "neural", "activity", "vertebrates", ",", "and", "ethosuximide", "and", "C0041038#ent", "<e1>", "are", "used", "to", "treat", "absence", "C0751495#ent", "<e2>", "in", "humans", "."], "h": {"id": "C0041038", "name": "C0041038#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [21, 22]}}
{"token": ["Four", "amatoxin-binding", "proteins", "C1705240#ent", "<e1>", "values", "in", "the", "nanomolar", "range", ",", "3", "monoclonal", "antibodies", "C0035679#ent", "<e2>", "were", "studied", "with", "respect", "to", "their", "affinities", "to", "24", "alpha-amanitin", "derivatives", "modified", "side", "chains", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [14, 15]}}
{"token": ["C0751931#ent", "<e1>", "occur", "with", "C0340629#ent", "<e2>", "commonly", "than", "reports", "in", "the", "literature", "indicate", "."], "h": {"id": "C0751931", "name": "C0751931#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0340629", "name": "C0340629#ent", "pos": [4, 5]}}
{"token": ["These", "experiments", "provide", "a", "previously", "uncharacterized", "mechanism", "for", "the", "anti-proliferative", "action", "of", "the", "parafibromin", "tumor", "suppressor", "protein", "from", "C1826536#ent", "<e1>", "complex-mediated", "inhibition", "of", "the", "C0086661#ent", "<e2>", "proto-oncogene", "."], "h": {"id": "C1826536", "name": "C1826536#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [24, 25]}}
{"token": ["The", "subnuclear", "distribution", "of", "serine-phosphorylated", "C0059239#ent", "<e1>", "and", "FRNK", "was", "examined", "in", "this", "study", "by", "double", "labeling", "C0060320#ent", "<e2>", ",", "a", "component", "of", "nucleoli", ",", "and", "Sam68", ",", "a", "constituent", "of", "Sam68", "nuclear", "bodies"], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0060320", "name": "C0060320#ent", "pos": [17, 18]}}
{"token": ["C1704824#ent", "<e1>", "expression", "and", "fluorescence", "in", "situ", "hybridisation", "C3274826#ent", "<e2>", ")", "amplification", "have", "therapeutic", "significance", "."], "h": {"id": "C1704824", "name": "C1704824#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3274826", "name": "C3274826#ent", "pos": [8, 9]}}
{"token": ["Treatments", "were", "1", ")", "no", "supplement", "control", ")", ",", "2", ")", "amide-protected", "C4283784#ent", "<e1>", "supplement", ",", "and", "3", ")", "C1519991#ent", "<e2>", "C4283784#ent", "<e1>", "supplement", "."], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1519991", "name": "C1519991#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "that", "I", "fistulosa", "induces", "a", "glycoprotein", "storage", "disease", "based", "on", "the", "inhibition", "of", "the", "C0283775#ent", "<e1>", "the", "alkaloid", "C0085535#ent", "<e2>", "."], "h": {"id": "C0283775", "name": "C0283775#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085535", "name": "C0085535#ent", "pos": [20, 21]}}
{"token": ["Percutaneous", "gallbladder", "drainage", "C3274756#ent", "<e1>", ")", "was", "performed", "in", "78", "patients", "with", "C0029896#ent", "<e2>", "of", "the", "bile", "duct", "system", "pancreas", ",", "including", "48", "patients", "with", "acute", "cholecystitis"], "h": {"id": "C3274756", "name": "C3274756#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "costs", "associated", "with", "development", "and", "testing", "of", "new", "C3274756#ent", "<e1>", "protocols", "have", "forced", "some", "C3274756#ent", "<e1>", "centres", "to", "limit", "the", "number", "of", "C0029896#ent", "<e1>", "for", "which", "C3274756#ent", "<e1>", "is", "offered", "."], "h": {"id": "C3274756", "name": "C3274756#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [25, 26]}}
{"token": ["Research", "in", "the", "field", "of", "preimplantation", "genetic", "diagnosis", "C3274756#ent", "<e1>", ")", "has", "concentrated", "on", "increasing", "the", "number", "of", "C0029896#ent", "<e2>", "diagnosed", ",", "different", "strategies", "for", "single", "cell", "analysis", "improving", "efficiency", "and", "reliability", "."], "h": {"id": "C3274756", "name": "C3274756#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [18, 19]}}
{"token": ["This", "study", "is", "a", "family-based", "genetic", "association", "analysis", "examining", "the", "C1416969#ent", "<e1>", "MAG", ")", "and", "2',3'-cyclic", "nucleotide", "3'-phosphodiesterase", "CNP", ")", "C1417679#ent", "<e2>", "in", "schizophrenia", "."], "h": {"id": "C1416969", "name": "C1416969#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["Physical", "mapping", "permitted", "placement", "of", "C1416969#ent", "<e1>", "and", "PLP", "C1417679#ent", "<e2>", "on", "the", "Genethon", "genetic", "map", "all", "other", "C1417679#ent", "<e2>", "were", "mapped", "on", "the", "Genethon", "genetic", "map", "linkage", "analysis"], "h": {"id": "C1416969", "name": "C1416969#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "plasma", "renin", "activity", "C3274822#ent", "<e1>", ")", "increased", "in", "both", "C0034372#ent", "<e2>", "and", "control", "subjects"], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034372", "name": "C0034372#ent", "pos": [12, 13]}}
{"token": ["Plasma", "renin", "activity", "(", "C3274822#ent", "<e1>", ")", "increased", "in", "both", "C0034372#ent", "<e2>", "and", "control", "subjects"], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034372", "name": "C0034372#ent", "pos": [10, 11]}}
{"token": ["PAR4AP-induced", "aggregation", "(", "but", "not", "PAR1AP-induced", "aggregation", ")", "was", "entirely", "C1417092#ent", "<e1>", "(", "abolished", "by", "C0003652#ent", "<e2>", ")", "and", "resistant", "to", "phenanthroline", "(", "MMP-2-independent", ")", "."], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003652", "name": "C0003652#ent", "pos": [15, 16]}}
{"token": ["Similarly", ",", "the", "introduction", "of", "the", "v-rasH", "oncogene", "basal", "cells", "a", "defective", "retroviral", "vector", "the", "expression", "of", "suprabasal", "C0010803#ent", "<e1>", "in", "1.4", "mM", "C1413043#ent", "<e2>", "+", "medium.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [23, 24]}}
{"token": ["Our", "results", "suggest", "the", "existence", "of", "a", "common", "nucleotide-binding", "site", "the", "polymerase", "and", "C1333243#ent", "<e1>", "pol", "lambda", "as", "well", "as", "distinct", "roles", "of", "the", "C3539947#ent", "<e2>", "and", "Phe506", "in", "these", "two", "catalytic", "functions"], "h": {"id": "C1333243", "name": "C1333243#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [24, 25]}}
{"token": ["Gaucher", "disease", "an", "inherited", "C0017361#ent", "<e1>", "autosomal", "metabolic", "defect", "to", "a", "deficiency", "of", "the", "C3539583#ent", "<e2>"], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539583", "name": "C3539583#ent", "pos": [14, 15]}}
{"token": ["G619", "dose-dependently", "inhibited", "U46619", ",", "C0009325#ent", "<e1>", ",", "ADP", ",", "PAF", ",", "C1414504#ent", "<e2>", "and", "epinephrine-induced", "platelet", "aggregation", "in", "vitro"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "after", "an", "acute", "coronary", "syndrome", "A+W", "and", "A+C", "are", "comparable", "in", "the", "prevention", "of", "MAEs", ",", "death", ",", "and", "C0340293#ent", "<e1>", "compared", "with", "C0004057#ent", "<e2>", "alone", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [26, 27]}}
{"token": ["In", "conclusion", ",", "subcutaneous", "heparin", "beneficial", "in", "C0340293#ent", "<e1>", ":", "however", ",", "the", "association", "with", "C0004057#ent", "<e2>", "does", "not", "add", "consistent", "benefits", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [15, 16]}}
{"token": ["Utilizing", "a", "combination", "of", "immunochemical", "mapping", ",", "enzymatic", "and", "chemical", "digestions", "and", "amino", "acid", "sequencing", "the", "cross-linking", "site", "the", "gamma", "chain", "peptide", "in", "C2697657#ent", "<e1>", "was", "localized", "to", "a", "stretch", "of", "21", "C3539947#ent", "<e2>"], "h": {"id": "C2697657", "name": "C2697657#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [32, 33]}}
{"token": ["ADP", "ribosylation", "in", "the", "presence", "of", "C0008354#ent", "<e1>", "or", "pertussis", "toxin", "the", "presence", "of", "C0086376#ent", "<e2>", "in", "Nb2", "cell", "membranes", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "(", "C0008354#ent", "<e1>", ",", "whooping", "cough", "of", "bacterial", "toxins", "target", "C0086376#ent", "<e2>", "covalent", "modification", "signal", "the", "potential", "importance", "of", "G", "protein", "dysfunction", "a", "cause", "of", "human", "disease"], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["On", "the", "fifth", "day", "of", "a", "course", "of", "antibiotic", "therapy", "C0520575#ent", "<e1>", "a", "21-year-old", "pregnant", "woman", "developed", "adult", "C0035220#ent", "<e2>"], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [18, 19]}}
{"token": ["This", "study", "was", "designed", "to", "assess", "the", "effect", "of", "long-term", "treatment", "with", "three", "combined", "oral", "contraceptives", "C3539565#ent", "<e1>", ")", "on", "the", "gonadotropin", "response", "C1415169#ent", "<e2>", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [23, 24]}}
{"token": ["Furthermore", ",", "the", "results", "of", "an", "experiment", "with", "2-[1(-14", ")", "C]oleoyl", "C3810569#ent", "<e1>", "showed", "that", "lipase", "having", "high", "C1334332#ent", "<e2>", "activity", "contained", "about", "5", "mol", "of", "C3810569#ent", "<e1>", "per", "mol", "of", "lipase", "."], "h": {"id": "C3810569", "name": "C3810569#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [18, 19]}}
{"token": ["C0006684#ent", "<e1>", "as", "nifedipine", "inhibit", "the", "vasoconstrictor", "actions", "of", "C1705518#ent", "<e2>", "on", "arteries", ",", "but", "not", "on", "veins", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705518", "name": "C1705518#ent", "pos": [9, 10]}}
{"token": ["C1537677#ent", "<e1>", "localizes", "to", "mitochondrial", "cristae", "the", "inner", "membrane", "C0010760#ent", "<e2>", "enriched", "."], "h": {"id": "C1537677", "name": "C1537677#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010760", "name": "C0010760#ent", "pos": [9, 10]}}
{"token": ["We", "had", "the", "opportunity", "to", "study", "an", "11-month-old", "male", "infant", "who", "underwent", "orthotopic", "liver", "transplantation", "C0023890#ent", "<e1>", "that", "developed", "in", "the", "setting", "of", "C0017923#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0017923", "name": "C0017923#ent", "pos": [23, 24]}}
{"token": ["Although", "C1366535#ent", "<e1>", "primarily", "administered", "for", "its", "antidiuretic", "effects", "the", "treatment", "of", "C0011848#ent", "<e2>", "the", "study", "demonstrates", "the", "often", "overlooked", "vasoactive", "effect", "C1366535#ent", "<e1>", "its", "use", "in", "a", "patient", "without", "C0011848#ent", "<e2>"], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [1, 2]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [12, 13]}}
{"token": ["DDAVP", ",", "1-desamino-8-D-arginine-vasopressin", ",", "is", "a", "synthetic", "analog", "C1366535#ent", "<e1>", "produces", "prolonged", "antidiuresis", "after", "intranasal", "administration", "patients", "with", "complete", "C0011848#ent", "<e2>"], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [19, 20]}}
{"token": ["This", "condition", "includes", "a", "large", "variety", "of", "forms", "of", "C0457506#ent", "<e1>", "a", "clonal", "increase", "thrombocytes", "in", "C0018939#ent", "<e2>", "and", "the", "rare", "condition", "of", "familial", "thrombocytosis"], "h": {"id": "C0457506", "name": "C0457506#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [16, 17]}}
{"token": ["No", "differences", "in", "binding", "characteristics", "were", "seen", "in", "EDL", "of", "C1705766#ent", "<e1>", "compared", "to", "C0019099#ent", "<e2>", "147", "animals", "."], "h": {"id": "C1705766", "name": "C1705766#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [14, 15]}}
{"token": ["Indirect", "immunofluorescence", "microscopy", "analysis", "using", "an", "affinity-purified", "anti-Tsg118", "serum", "shows", "colocalization", "of", "C2608050#ent", "<e1>", "and", "a", "known", "nucleolar", "protein", "C1414538#ent", "<e2>", ",", "to", "the", "dense", "fibrillar", "component", "the", "nucleolus", "."], "h": {"id": "C2608050", "name": "C2608050#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414538", "name": "C1414538#ent", "pos": [19, 20]}}
{"token": ["C1418303#ent", "<e1>", "sensors", "for", "Ni2+", "with", "5-amino-8-hydroxyquinoline", "as", "a", "C3537172#ent", "<e2>", "were", "tested", "in", "aqueous", "solutions", "and", "diluted", "human", "plasma", "."], "h": {"id": "C1418303", "name": "C1418303#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537172", "name": "C3537172#ent", "pos": [9, 10]}}
{"token": ["Telithromycin", "(", "HMR", "3647", ")", "is", "the", "first", "member", "of", "a", "new", "family", "of", "antimicrobials", ",", "the", "C1449860#ent", "<e1>", ",", "developed", "specifically", "for", "the", "treatment", "of", "C0206171#ent", "<e2>"], "h": {"id": "C1449860", "name": "C1449860#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0206171", "name": "C0206171#ent", "pos": [26, 27]}}
{"token": ["The", "pharmacodynamics", "of", "telithromycin", ",", "a", "new", "C1449860#ent", "<e1>", "was", "examined", "in", "115", "patients", "with", "C0206171#ent", "<e2>", "CAP", ")", "."], "h": {"id": "C1449860", "name": "C1449860#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0206171", "name": "C0206171#ent", "pos": [15, 16]}}
{"token": ["Paradoxically", ",", "cAMP-producing", "agents", ",", "which", "stimulate", "C3537460#ent", "<e1>", "activity", "in", "isosmotic", "conditions", ",", "suppressed", "C0020457#ent", "<e2>", "glucose-", "and", "mannitol-induced", "C3537460#ent", "<e1>", "activity", "and", "prevented", "restoration", "of", "muscle", "cell", "volume", "in", "hyperosmotic", "media"], "h": {"id": "C3537460", "name": "C3537460#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020457", "name": "C0020457#ent", "pos": [15, 16]}}
{"token": ["The", "samples", "analyzed", "were", "obtained", "from", "control", "subjects", "patients", "with", "C0086795#ent", "<e1>", ",", "and", "patients", "with", "a", "few", "other", "kinds", "of", "C0018995#ent", "<e2>"], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [21, 22]}}
{"token": ["Hurler", "syndrome", "C0086795#ent", "<e1>", "MPS", "IH", "is", "a", "congenital", "mucopolysaccharide", "C0018995#ent", "<e2>", "from", "a", "genetic", "deficiency", "alpha-L-iduronidase", "(", "IDUA", ")", ",", "which", "is", "required", "for", "lysosomal", "degradation", "glycosaminoglycans", "heparan", "sulfate", "dermatan", "sulfate"], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [10, 11]}}
{"token": ["We", "can", "not", "definitely", "conclude", "that", "the", "disease", "of", "these", "3", "cases", "were", "same", "diseases", "to", "be", "called", "either", "C0041296#ent", "<e1>", "peripleural", "abscess", "or", "C0041326#ent", "<e2>", "observed", "in", "case", "1", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0041326", "name": "C0041326#ent", "pos": [24, 25]}}
{"token": ["Several", "lines", "of", "genetic", "and", "biochemical", "evidence", "indicated", "that", "lipoteichoic", "acid", "LTA", ")", ",", "the", "most", "widely", "studied", "C1336634#ent", "<e1>", "agonist", "in", "C0085426#ent", "<e2>", "was", "not", "essential", "for", "C1336634#ent", "<e1>", "activation", "."], "h": {"id": "C1336634", "name": "C1336634#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0085426", "name": "C0085426#ent", "pos": [22, 23]}}
{"token": ["The", "up-regulation", "of", "C1336634#ent", "<e1>", "may", "be", "of", "relevance", "for", "the", "vascular", "effects", "C0085426#ent", "<e2>"], "h": {"id": "C1336634", "name": "C1336634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085426", "name": "C0085426#ent", "pos": [13, 14]}}
{"token": ["However", ",", "when", "performing", "either", "C1412101#ent", "<e1>", "or", "behavioural", "C3540469#ent", "<e2>", "hearing", "threshold", "measurements", "it", "is", "essential", "to", "be", "aware", "of", "the", "limitations", "of", "the", "hearing", "aid", "and", "the", "stimulus", "."], "h": {"id": "C1412101", "name": "C1412101#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540469", "name": "C3540469#ent", "pos": [9, 10]}}
{"token": ["It", "has", "been", "noted", "that", "putative", "phosphorylation", "sites", "for", "various", "C0030940#ent", "<e1>", "in", "rat", "C1415855#ent", "<e2>", ",", "Id2", "and", "Id3", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415855", "name": "C1415855#ent", "pos": [14, 15]}}
{"token": ["The", "interaction", "between", "C0276623#ent", "<e1>", "HCV", ")", "infection", "and", "C0004096#ent", "<e2>", "of", "considerable", "interest", "."], "h": {"id": "C0276623", "name": "C0276623#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [9, 10]}}
{"token": ["Apoptosis", "studies", "showed", "up", "to", "1.6-fold", "increase", "in", "annexin", "V", "positive", "cells", "when", "the", "C0949665#ent", "<e1>", "were", "combined", "with", "C0594375#ent", "<e2>", "as", "compared", "to", "C0594375#ent", "<e2>", "alone", "."], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [19, 20]}}
{"token": ["Gold", "(", "Au", ")", "C0018033#ent", "<e1>", ",", "used", "to", "treat", "C0033581#ent", "<e2>", "as", "rheumatoid", "arthritis", "inhibits", "the", "selenium", "(Se)-dependent", "glutathione", "peroxidase"], "h": {"id": "C0018033", "name": "C0018033#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [10, 11]}}
{"token": ["We", "report", "a", "case", "of", "C1527231#ent", "<e1>", "(", "AMN", ")", "in", "which", "serial", "urodynamic", "studies", "C0005697#ent", "<e2>"], "h": {"id": "C1527231", "name": "C1527231#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [15, 16]}}
{"token": ["In", "rodent", "adipocyte", "transcription", "of", "the", "PEPCK-C", "gene", "is", "induced", "by", "C3541957#ent", "<e1>", "(", "TZDs", ")", "through", "an", "element", ",", "named", "C1418372#ent", "<e2>", ",", "in", "its", "promoter", "."], "h": {"id": "C3541957", "name": "C3541957#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418372", "name": "C1418372#ent", "pos": [21, 22]}}
{"token": ["Immunoblot", "analysis", "antibodies", "specific", "to", "15(S)-lipoxygenase-1", "(", "LOX-1", ")", "and", "15(S)-lipoxygenase-2", "(", "C1540289#ent", "<e1>", ")", "demonstrated", "the", "expression", "of", "15-LOX-2", ",", "but", "not", "C3889710#ent", "<e2>", ",", "in", "these", "tumor", "cells"], "h": {"id": "C1540289", "name": "C1540289#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3889710", "name": "C3889710#ent", "pos": [23, 24]}}
{"token": ["In", "the", "C1418664#ent", "<e1>", "recording", ",", "the", "middle-latency", "components", "(", "N140", "and", "C1415176#ent", "<e2>", ")", "were", "identified", "as", "being", "maximal", "around", "the", "vertex", "."], "h": {"id": "C1418664", "name": "C1418664#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415176", "name": "C1415176#ent", "pos": [12, 13]}}
{"token": ["The", "cytotoxic", "effect", "the", "new", "potential", "intercalating", "anticancer", "drug", "oracin", "was", "studied", "on", "Burkitt's", "lymphoma", "cell", "line", "overexpressed", "C1704467#ent", "<e1>", "(", "BL", "C1704467#ent", "<e1>", ")", "and", "a", "control", "transfectant", "without", "the", "bcl-2", "gene", "BL", "C1427005#ent", "<e1>", ")", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1427005", "name": "C1427005#ent", "pos": [34, 35]}}
{"token": ["Two", "of", "the", "eight", "C3469521#ent", "<e1>", "genes", "have", "been", "cloned", "(", "C0060441#ent", "<e2>", "and", "FAC", ")", ",", "but", "their", "function", "has", "not", "yet", "been", "defined", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060441", "name": "C0060441#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "suggest", "that", "acetylator", "phenotype", "does", "not", "influence", "the", "therapeutic", "response", "individuals", "infected", "with", "falciparum", "C0024530#ent", "<e1>", "to", "sulfalene", "or", "to", "the", "combination", "of", "sulfalene", "and", "C0034283#ent", "<e2>", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [27, 28]}}
{"token": ["Upon", "discontinuation", "of", "the", "C0024530#ent", "<e1>", "prophylaxis", "with", "Daraclor", "(", "C0034283#ent", "<e2>", "and", "chloroquine", "(", "sulphate", ")", ")", "the", "symptoms", "disappeared", "and", "the", "liver", "function", "tests", "to", "normal", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [10, 11]}}
{"token": ["In", "a", "controlled", "trial", "weekly", "C0024530#ent", "<e1>", "chemoprophylaxis", "with", "chloroquine", "and", "C0034283#ent", "<e2>", "there", "were", "no", "significant", "in", "type", "and", "frequency", "of", "severe", "morbidity", "during", "chemoprophylaxis", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [11, 12]}}
{"token": ["The", "crystal", "structures", "complexes", "of", "the", "C2717969#ent", "<e1>", "human", "and", "C0035094#ent", "<e2>", "yeast", "proteinase", "A", "cathepsin", "D", "with", "peptide", "analogue", "inhibitors", "are", "compared", "."], "h": {"id": "C2717969", "name": "C2717969#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035094", "name": "C0035094#ent", "pos": [10, 11]}}
{"token": ["Chronic", "renal", "failure", "C1538975#ent", "<e1>", ")", "is", "often", "associated", "with", "C0005940#ent", "<e2>", "chronic", "kidney", "disease-mineral", "bone", "disorder", "CKD-MBD", ")", "."], "h": {"id": "C1538975", "name": "C1538975#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [10, 11]}}
{"token": ["No", "evidence", "was", "obtained", "suggesting", "a", "C0242898#ent", "<e1>", "mediation", "for", "the", "functional", "interaction", "of", "C0008188#ent", "<e2>", "with", "5-HT", "neurons", "in", "this", "experimental", "model"], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "C1332077#ent", "<e1>", "samples", "obtained", "from", "patients", "with", "various", "C0034087#ent", "<e2>", "studied", "."], "h": {"id": "C1332077", "name": "C1332077#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034087", "name": "C0034087#ent", "pos": [10, 11]}}
{"token": ["The", "protective", "effect", "intracerebroventricular", "C1418716#ent", "<e1>", "was", "blocked", "by", "atropine", ",", "subdiaphragmatic", "vagotomy", "and", "C0054040#ent", "<e2>", "."], "h": {"id": "C1418716", "name": "C1418716#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054040", "name": "C0054040#ent", "pos": [14, 15]}}
{"token": ["In", "fetal", "lung", "C0669365#ent", "<e1>", "expression", "was", "evident", "in", "C0719022#ent", "<e2>", "and", "proximal", "bronchiolar", "epithelia", "but", "was", "absent", "in", "terminal", "and", "respiratory", "bronchioles", "alveolar", "epithelium"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [9, 10]}}
{"token": ["Similar", "to", "C0669365#ent", "<e1>", ",", "iNOS", "was", "detected", "in", "C0719022#ent", "<e2>", "and", "proximal", "bronchiolar", "epithelia", "but", "not", "in", "alveolar", "epithelium"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [9, 10]}}
{"token": ["A", "progressive", "C0019537#ent", "<e1>", "in", "six", "children", "with", "longstanding", "C0860204#ent", "<e2>"], "h": {"id": "C0019537", "name": "C0019537#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0860204", "name": "C0860204#ent", "pos": [9, 10]}}
{"token": ["Ixabepilone", "(", "C0879430#ent", "<e1>", ")", "is", "a", "semisynthetic", "analog", "of", "C1136012#ent", "<e2>", "has", "shown", "antitumor", "activity", "in", "vitro", "in", "vivo", "including", "taxane-resistant", "human", "tumor", "xenograft", "models"], "h": {"id": "C0879430", "name": "C0879430#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1136012", "name": "C1136012#ent", "pos": [10, 11]}}
{"token": ["C0879430#ent", "<e1>", "is", "a", "semisynthetic", "derivative", "of", "C1136012#ent", "<e2>", "mechanism", "of", "action", "analogous", "to", "paclitaxel", "."], "h": {"id": "C0879430", "name": "C0879430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1136012", "name": "C1136012#ent", "pos": [7, 8]}}
{"token": ["Unusual", "susceptibility", "to", "C0026918#ent", "<e1>", "be", "caused", "by", "deleterious", "mutations", "genes", "that", "encode", "the", "C1334083#ent", "<e2>"], "h": {"id": "C0026918", "name": "C0026918#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1334083", "name": "C1334083#ent", "pos": [14, 15]}}
{"token": ["Only", "IL-15", ",", "but", "not", "C0879590#ent", "<e1>", ",", "completely", "protected", "from", "lethal", "C0162557#ent", "<e2>"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [12, 13]}}
{"token": ["C1836330#ent", "<e1>", "is", "also", "characterized", "by", "ichthyosis", ",", "sensorineural", "hearing", "loss", "C0031117#ent", "<e2>", "psychomotor", "retardation", "congenital", "chronic", "diarrhea", "and", "an", "elevation", "of", "very", "long", "chain", "fatty", "acids", "(", "VLCFAs", ")", "."], "h": {"id": "C1836330", "name": "C1836330#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [11, 12]}}
{"token": ["Results", "of", "this", "study", "should", "prove", "useful", "in", "guiding", "the", "clinical", "application", "these", "novel", "C0035064#ent", "<e1>", "in", "the", "treatment", "of", "C1704799#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1704799", "name": "C1704799#ent", "pos": [20, 21]}}
{"token": ["Methotrexate", "(", "MTX", ")", "is", "one", "of", "the", "most", "active", "and", "widely", "used", "C0035064#ent", "<e1>", "for", "the", "treatment", "of", "acute", "lymphoblastic", "leukemia", "C1704799#ent", "<e2>", ")", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704799", "name": "C1704799#ent", "pos": [22, 23]}}
{"token": ["C0132513#ent", "<e1>", "is", "a", "cell", "cycle", "regulated", "C0010536#ent", "<e2>", ",", "in", "addition", "to", "p34cdc2/cyclin", "B", ",", "for", "initiation", "of", "mitosis", "in", "Aspergillus", "nidulans"], "h": {"id": "C0132513", "name": "C0132513#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [7, 8]}}
{"token": ["The", "Aspergillus", "nidulans", "protein", "C0132513#ent", "<e1>", "(", "never", "in", "mitosis", ",", "gene", "A", "is", "a", "C0010536#ent", "<e2>", "for", "the", "initiation", "of", "mitosis", ",", "whereas", "its", "inactivation", "is", "necessary", "for", "mitotic", "exit"], "h": {"id": "C0132513", "name": "C0132513#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [15, 16]}}
{"token": ["C0023264#ent", "<e1>", "Leigh", "syndrome", "is", "characterized", "by", "C0001125#ent", "<e2>", ",", "seizures", ",", "ataxia", ",", "multiple", "cerebral", "hypervascularized", "lesions", "and", "mitochondrial", "oxidation", "defects", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0001125", "name": "C0001125#ent", "pos": [7, 8]}}
{"token": ["The", "deficiency", "of", "the", "putative", "C0295398#ent", "<e1>", "associates", "with", "the", "rare", "C0574083#ent", "<e2>", "MGA1", ")", ",", "but", "neither", "the", "enzyme", "nor", "its", "gene", "have", "been", "described", "in", "any", "organism", "."], "h": {"id": "C0295398", "name": "C0295398#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0574083", "name": "C0574083#ent", "pos": [11, 12]}}
{"token": ["Interaction", "at", "GC", "box", "IV", "when", "the", "three", "proximal", "boxes", "were", "in", "a", "C2987364#ent", "<e1>", "configuration", "had", "no", "effect", "transcription", "of", "the", "C0039667#ent", "<e2>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [22, 23]}}
{"token": ["In", "the", "present", "study", ",", "the", "sequence", "specificity", "DNA", "alkylation", "C0672092#ent", "<e1>", "was", "determined", "in", "the", "C1705526#ent", "<e2>", "cDNA", "through", "the", "conversion", "of", "the", "adducted", "sites", "single", "strand", "breaks", "sequencing", "gel", "analysis"], "h": {"id": "C0672092", "name": "C0672092#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [16, 17]}}
{"token": ["Treatment", "with", "C0672092#ent", "<e1>", "and", "3-aminobenzamide", "results", "in", "augmented", "expression", "of", "C1705526#ent", "<e2>", "of", "the", "X-ray", "repair", "cross-complementing", "1", "transcript", "a", "component", "of", "base", "excision", "repair", "."], "h": {"id": "C0672092", "name": "C0672092#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [11, 12]}}
{"token": ["Reports", "that", "describe", "the", "C4053934#ent", "<e1>", "and", "progression", "of", "renal", "disease", "patients", "with", "type", "2", "diabetes", "that", "the", "C0012634#ent", "<e2>", "similar", "to", "that", "observed", "in", "patients", "with", "type", "1", "diabetes", "diabetic", "nephropathy"], "h": {"id": "C4053934", "name": "C4053934#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["There", "is", "sufficient", "clinical", "and", "morphological", "evidence", "to", "suggest", "that", "Fibrillary", "Glomerulonephritis", "FGN", ")", "and", "Immunotactoid", "(", "IT", ")", "C4053934#ent", "<e1>", "are", "two", "different", "C0012634#ent", "<e2>", "."], "h": {"id": "C4053934", "name": "C4053934#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["Nicardipine", "strongly", "inhibited", "two-pathways", "of", "C0040879#ent", "<e1>", "hydroxylation", "both", "catalyzed", "by", "C1142644#ent", "<e2>", "."], "h": {"id": "C0040879", "name": "C0040879#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}}
{"token": ["Four", "antiemetics", "(", "dixyrazin", ",", "metoclopramide", ",", "chlorpromazine", "and", "C0013136#ent", "<e1>", ")", "augmented", "the", "inhibition", "by", "C0014582#ent", "<e2>", "."], "h": {"id": "C0013136", "name": "C0013136#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [16, 17]}}
{"token": ["Clonidine", "'s", "threshold", "(", "greater", "than", "10", "mmHg", ",", "less", "than", "20", "mmHg", ")", "C0003364#ent", "<e1>", "potentiated", "by", "C0031448#ent", "<e2>", "but", "opposed", "by", "centrally", "acting", "antagonists", "as", "was", "the", "maximal", "C0003364#ent", "<e1>"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [18, 19]}}
{"token": ["LPS", "did", "not", "alter", "the", "C0003364#ent", "<e1>", "induced", "by", "C0031448#ent", "<e2>", ",", "verapamil", ",", "or", "SIN-1", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [9, 10]}}
{"token": ["In", "the", "case", "of", "on", "C0021843#ent", "<e1>", "resection", "of", "the", "C0277565#ent", "<e2>", "bowel", "with", "primary", "anastomosis", "preferred", "."], "h": {"id": "C0021843", "name": "C0021843#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [10, 11]}}
{"token": ["When", "expressed", "in", "S.", "cerevisiae", "this", "gene", "efficiently", "complements", "some", "of", "the", "phenotypes", "associated", "with", "yap1", "and", "C1424135#ent", "<e1>", "mutations", "and", "also", "mediates", "C0162508#ent", "<e2>", "response", "element-dependent", "transcriptional", "activation", "in", "response", "to", "H2O2", "."], "h": {"id": "C1424135", "name": "C1424135#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [23, 24]}}
{"token": ["When", "expressed", "in", "S.", "cerevisiae", "this", "gene", "efficiently", "complements", "some", "of", "the", "phenotypes", "associated", "with", "C1424135#ent", "<e1>", "and", "yap2", "mutations", "and", "also", "mediates", "C0162508#ent", "<e2>", "response", "element-dependent", "transcriptional", "activation", "in", "response", "to", "H2O2", "."], "h": {"id": "C1424135", "name": "C1424135#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [23, 24]}}
{"token": ["The", "C1424135#ent", "<e1>", "and", "YAP2", "genes", "yeast", "transcription", "factors", "the", "C0162508#ent", "<e2>"], "h": {"id": "C1424135", "name": "C1424135#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [10, 11]}}
{"token": ["The", "binding", "profiles", "identified", "in", "this", "study", "can", "be", "used", "to", "predict", "the", "potential", "transportability", "of", "nucleoside", "analogs", "including", "C0003392#ent", "<e1>", "or", "antiviral", "nucleoside", "drugs", "by", "C3272517#ent", "<e2>", "and", "hCNT3", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3272517", "name": "C3272517#ent", "pos": [26, 27]}}
{"token": ["In", "addition", ",", "C0069562#ent", "<e1>", "was", "shown", "to", "inhibit", "high", "concentrations", "CCK-8S-induced", "biphasic", "increases", "in", "[Ca2+]i", ",", "suggesting", "that", "C0069562#ent", "<e1>", "might", "be", "a", "partial", "C0243192#ent", "<e1>", "at", "cholecystokinin", "CCK1", "receptors"], "h": {"id": "C0069562", "name": "C0069562#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [25, 26]}}
{"token": ["Inhibitory", "phosphorylation", "of", "MPF", "correlated", "with", "phosphorylation", "changes", "of", "C1413259#ent", "<e1>", ",", "the", "MPF", "phosphatase", "and", "physical", "interaction", "C1332721#ent", "<e2>", "with", "wee1", ",", "the", "MPF", "kinase", ",", "during", "M-phase", "exit"], "h": {"id": "C1413259", "name": "C1413259#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332721", "name": "C1332721#ent", "pos": [18, 19]}}
{"token": ["In", "vitro", "we", "demonstrate", "a", "C1413043#ent", "<e1>", "+", "-dependent", "and", "-specific", "interaction", "between", "C0251914#ent", "<e2>", "and", "L4", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0251914", "name": "C0251914#ent", "pos": [13, 14]}}
{"token": ["The", "melphalan-resistant", "DU", "145", "and", "PC-3", "lines", "cross-resistance", "to", "cisplatin", "and", "C0076329#ent", "<e1>", ",", "but", "retained", "sensitivity", "to", "C0042671#ent", "<e2>", ",", "colchicine", "and", "etoposide", "."], "h": {"id": "C0076329", "name": "C0076329#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042671", "name": "C0042671#ent", "pos": [18, 19]}}
{"token": ["We", "now", "report", "that", "the", "human", "C2700453#ent", "<e1>", "contained", "within", "the", "C0270911#ent", "<e2>"], "h": {"id": "C2700453", "name": "C2700453#ent", "pos": [6, 7]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [11, 12]}}
{"token": ["We", "have", "investigated", "the", "peripheral", "myelin", "protein", "gene", "C2700453#ent", "<e1>", ",", "in", "a", "family", "with", "Charcot-Marie-Tooth", "disease", "type", "1A", "C0270911#ent", "<e2>", ")", "."], "h": {"id": "C2700453", "name": "C2700453#ent", "pos": [8, 9]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [19, 20]}}
{"token": ["Epicholesterol", "and", "cholesteryl", "sulfate", "for", "[(3)H]cholesterol", "binding", "to", "C1422736#ent", "<e1>", ",", "but", "not", "C1417776#ent", "<e2>", "."], "h": {"id": "C1422736", "name": "C1422736#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417776", "name": "C1417776#ent", "pos": [13, 14]}}
{"token": ["Current", "data", "have", "led", "to", "the", "hypothesis", "that", "C1422736#ent", "<e1>", "would", "bind", "cholesterol", "from", "internal", "lysosomal", "membranes", "enabling", "a", "physical", "interaction", "C1417776#ent", "<e2>", "(", "or", "another", "protein", ")", "and", "allowing", "postlysosomal", "export", "of", "cholesterol", "."], "h": {"id": "C1422736", "name": "C1422736#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417776", "name": "C1417776#ent", "pos": [21, 22]}}
{"token": ["Since", "it", "was", "first", "introduced", "'", "C0060061#ent", "<e1>", "'", "(", "pyrimethamine", "25", "mg", ",", "C0038679#ent", "<e2>", "500", "mg", ")", "has", "been", "the", "preferred", "treatment", "for", "uncomplicated", "chloroquine-resistant", "Plasmodium", "falciparum", "malaria", "in", "Thailand", "."], "h": {"id": "C0060061", "name": "C0060061#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038679", "name": "C0038679#ent", "pos": [14, 15]}}
{"token": ["The", "data", "indicate", "that", "apoE", "deficiency", "KO", "mice", "associated", "with", "delayed", "recovery", "of", "the", "glomerular", "area", "a", "slower", "recovery", "in", "C0812303#ent", "<e1>", "concentration", "in", "the", "C3273409#ent", "<e2>", "."], "h": {"id": "C0812303", "name": "C0812303#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3273409", "name": "C3273409#ent", "pos": [25, 26]}}
{"token": ["Mice", "overexpressing", "C3811709#ent", "<e1>", "osteoblasts", "through", "selective", "deletion", "of", "the", "C0019562#ent", "<e2>", "Vhl", ")", "expressed", "high", "levels", "of", "Vegf", "and", "developed", "extremely", "dense", ",", "heavily", "vascularized", "long", "bones"], "h": {"id": "C3811709", "name": "C3811709#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [10, 11]}}
{"token": ["While", "C3811709#ent", "<e1>", "activation", "explains", "the", "highly", "vascularized", "nature", "of", "C0019562#ent", "<e2>", "loss", "lesions", "the", "relative", "role", "of", "C3811709#ent", "<e1>", "in", "oncogenesis", "and", "loss", "of", "growth", "control", "unknown", "."], "h": {"id": "C3811709", "name": "C3811709#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [10, 11]}}
{"token": ["Unlike", "malignant", "melanomas", "C3813543#ent", "<e1>", "show", "no", "C1705526#ent", "<e2>", "immunoreactivity", ",", "and", "low", "proliferative", "activity", "was", "detected", "by", "Ki-67", "antigen", "immunostaining"], "h": {"id": "C3813543", "name": "C3813543#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [7, 8]}}
{"token": ["C0073393#ent", "<e1>", "has", "not", "been", "associated", "with", "blood", "dyscrasias", "increased", "risk", "of", "C0036572#ent", "<e2>", ",", "but", "weight", "gain", "be", "a", "problem", "for", "some", "patients", "."], "h": {"id": "C0073393", "name": "C0073393#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}}
{"token": ["C0073393#ent", "<e1>", "was", "discontinued", ",", "but", "stupor", ",", "C0036572#ent", "<e2>", ",", "and", "respiratory", "distress", "."], "h": {"id": "C0073393", "name": "C0073393#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}}
{"token": ["The", "C1418549#ent", "<e1>", "rapamycin", "strongly", "interferes", "with", "transformation", "induced", "by", "C0669365#ent", "<e2>", "active", "Rheb", ",", "suggesting", "that", "TOR", "activity", "is", "essential", "for", "the", "oncogenic", "effects", "mutant", "Rheb", "."], "h": {"id": "C1418549", "name": "C1418549#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [10, 11]}}
{"token": ["Administration", "of", "wortmannin", "(", "phosphatidylinositol", "3-kinase", "C1418549#ent", "<e1>", "inhibitor", ")", "attenuated", "the", "phosphorylation", "of", "Akt", "and", "C0669365#ent", "<e2>", "and", "reduced", "C0669365#ent", "<e2>", "activity", "."], "h": {"id": "C1418549", "name": "C1418549#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [16, 17]}}
{"token": ["Links", "with", "the", "C0025007#ent", "<e1>", "component", "of", "the", "measles-mumps-rubella", "vaccine", "the", "cumulative", "exposure", "to", "C0039867#ent", "<e2>", "through", "other", "vaccines", "have", "been", "postulated", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039867", "name": "C0039867#ent", "pos": [14, 15]}}
{"token": ["Tests", "for", "C0041323#ent", "<e1>", "in", "children", "with", "C0743359#ent", "<e2>", "be", "mandatory", ",", "but", "periodic", "testing", "of", "all", "children", "is", "recommended", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0743359", "name": "C0743359#ent", "pos": [7, 8]}}
{"token": ["Despite", "an", "increasing", "population", "of", "patients", "with", "C0403447#ent", "<e1>", "the", "literature", "on", "the", "management", "of", "urinary", "tract", "infections", "C1412376#ent", "<e2>", ")", "in", "these", "patients", "is", "sparse", "."], "h": {"id": "C0403447", "name": "C0403447#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412376", "name": "C1412376#ent", "pos": [18, 19]}}
{"token": ["The", "prevalence", "of", "the", "C0039082#ent", "<e1>", "in", "the", "adult", "C0282556#ent", "<e2>", "populations", "is", "approximately", "4", "-", "10", "%", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [9, 10]}}
{"token": ["Sea", "tangle", "C0142791#ent", "<e1>", "not", "affect", "activities", "of", "catalase", "and", "C0763282#ent", "<e2>", "however", ",", "supplementation", "of", "water", "extract", "sea", "tangle", "in", "higher", "superoxide", "dismutase", "activity", "as", "compared", "with", "the", "control", "and", "C0142791#ent", "<e1>", "groups", "."], "h": {"id": "C0142791", "name": "C0142791#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0763282", "name": "C0763282#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "RAP-treated", "CTLL-2", "cells", "retained", "the", "ability", "to", "respond", "to", "C0879590#ent", "<e1>", "with", "enhanced", "cytolytic", "activity", ",", "indicating", "that", "C1416920#ent", "<e2>", "was", "not", "a", "general", "suppressant", "of", "cellular", "responsiveness", "C0879590#ent", "<e1>", "."], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "whether", "C1416920#ent", "<e1>", "exerts", "a", "total", "blockade", "of", "the", "IL-2R", "signaling", "pathway", "we", "induced", "CTL", "in", "the", "presence", "of", "both", "C1416920#ent", "<e1>", "and", "exogenous", "C0879590#ent", "<e1>", "(", "100", "U/ml", ")", "."], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [26, 27]}}
{"token": ["We", "investigated", "the", "effects", "on", "cerebral", "perfusion", "the", "C0006684#ent", "<e1>", "lacidipine", "and", "of", "hydrochlorothiazide", "(", "C0020261#ent", "<e2>", ")", "in", "asymptomatic", "hypertensive", "patients", "with", "concomitant", "atherosclerosis", "of", "the", "carotid", "arteries"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [15, 16]}}
{"token": ["We", "compared", "amlodipine", ",", "a", "C0006684#ent", "<e1>", "to", "placebo", "as", "add-on", "therapy", "to", "C0020261#ent", "<e2>", "in", "91", "hypertensive", "patients", "inadequately", "controlled", "on", "C0020261#ent", "<e2>", "(", "50", "mg/d", "for", "four", "weeks", ")", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [13, 14]}}
{"token": ["Lack", "of", "C3539185#ent", "<e1>", ",", "such", "as", "untreated", "C2103602#ent", "<e2>", "can", "be", "fatal", "in", "humans", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2103602", "name": "C2103602#ent", "pos": [8, 9]}}
{"token": ["A", "21", "years", "old", "female", "patient", "with", "C0011859#ent", "<e1>", "a", "distinct", "C1848862#ent", "<e2>", "of", "insulin", "resistant", "diabetes", "mellitus", "loss", "of", "subcutaneous", "fat", "hepatosplenomegaly", ",", "hyperlipidemia", ",", "increased", "basal", "metabolic", ",", "subvalvular", "aortic", "stenosis", "cystic", "bone", "lesions", "described", "."], "h": {"id": "C0011859", "name": "C0011859#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [11, 12]}}
{"token": ["C0011859#ent", "<e1>", "LD", ")", "is", "a", "C1848862#ent", "<e2>", "with", "congenital", "or", "delayed", "onset", ",", "characterized", "by", "severe", "insulin", "resistance", "generalized", "lipoatrophy"], "h": {"id": "C0011859", "name": "C0011859#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [6, 7]}}
{"token": ["Nuclear", "antigen", "14", "kDa", "(", "NA14", ")", ",", "an", "C1413096#ent", "<e1>", "of", "Sj\u00f6gren's", "syndrome", "was", "identified", "as", "a", "binding", "protein", "the", "C-terminal", "region", "C1539611#ent", "<e2>", "."], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539611", "name": "C1539611#ent", "pos": [23, 24]}}
{"token": ["A", "precipitated", "C1332133#ent", "<e1>", "elicited", "with", "CGS-8216", "in", "rats", "chronically", "dosed", "with", "C0012010#ent", "<e2>", "and", "was", "very", "similar", "to", "the", "C1332133#ent", "<e1>", "precipitated", "by", "Ro15", "-", "1788", "in", "diazepam-dependent", "rats", "."], "h": {"id": "C1332133", "name": "C1332133#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "levels", "of", "anti-HCV", "IgM", "C1413512#ent", "<e1>", "patients", "were", "associated", "significantly", "the", "level", "of", "C0002594#ent", "<e2>", "a", "finding", "that", "can", "be", "used", "in", "monitoring", "disease", "activity", "such", "a", "group", "of", "patients", "."], "h": {"id": "C1413512", "name": "C1413512#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [16, 17]}}
{"token": ["To", "further", "document", "an", "implication", "of", "C1868682#ent", "<e1>", "in", "activation", "of", "JNK", "and", "C1705633#ent", "<e2>", "induced", "by", "BMP-2", ",", "we", "constructed", "MC3T3-E1", "cells", "stably", "expressing", "C1868682#ent", "<e1>", "antisense", "oligonucleotide", "AS-PKD", ")", "."], "h": {"id": "C1868682", "name": "C1868682#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "report", "a", "new", "gene", ",", "named", "C3147238#ent", "<e1>", ",", "that", "is", "upregulated", "in", "C1418943#ent", "<e2>", "E1A", "cells", "."], "h": {"id": "C3147238", "name": "C3147238#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [15, 16]}}
{"token": ["The", "activity", "was", "resistant", "to", "treatment", "with", "C0041236#ent", "<e1>", ",", "pronase", ",", "or", "C0025965#ent", "<e2>"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025965", "name": "C0025965#ent", "pos": [13, 14]}}
{"token": ["Additional", "results", "strongly", "suggested", "that", "the", "CD95-ligand", "(", "C1706006#ent", "<e1>", ")", "was", "a", "major", "cause", "of", "neuronal", "autocrine", "suicide", "the", "C1823520#ent", "<e2>", "."], "h": {"id": "C1706006", "name": "C1706006#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1823520", "name": "C1823520#ent", "pos": [20, 21]}}
{"token": ["The", "C0003392#ent", "<e1>", "properties", "of", "C0111352#ent", "<e2>", "a", "new", "nitrosoureido", "sugar", ",", "were", "investigated", "in", "two", "murine", "solid", "tumours", "B16", "melanoma", "subcutaneously", "implanted", "colon", "adenocarcinoma"], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0111352", "name": "C0111352#ent", "pos": [5, 6]}}
{"token": ["The", "receptor", "was", "expressed", "transiently", "in", "C1705516#ent", "<e1>", "and", "NIH3T3", "cells", "in", "the", "presence", "of", "C2987364#ent", "<e2>", ",", "dominant", "negative", "or", "constitutively", "active", "forms", "PKC", "delta"], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [15, 16]}}
{"token": ["It", "has", "been", "shown", "that", "C0001047#ent", "<e1>", "(", "NAC", ")", ",", "a", "glutathione", "prodrug", "and", "acetyl-L-carnitine", "(", "C0600146#ent", "<e2>", ")", ",", "a", "mitochondrial", "biogenesis", "agent", "are", "effective", "in", "reducing", "noise-induced", "hearing", "loss"], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0600146", "name": "C0600146#ent", "pos": [17, 18]}}
{"token": ["Two", "murine", "Mabs", "VA1(IgG1", ")", "and", "VA2(IgG1", ")", "were", "produced", "against", "a", "bacterial", "fusion", "protein", "C1415329#ent", "<e1>", "five", "tandem", "repeats", "the", "C1705281#ent", "<e2>"], "h": {"id": "C1415329", "name": "C1415329#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [21, 22]}}
{"token": ["The", "C1136254#ent", "<e1>", "properties", "of", "essential", "oils", "C0348029#ent", "<e2>", ",", "and", "orange", "oil", "in", "particular", ",", "varied", "according", "to", "the", "type", "of", "bacteria", "tested", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0348029", "name": "C0348029#ent", "pos": [7, 8]}}
{"token": ["C0003211#ent", "<e1>", "cyclo", "3", "fort", "flutamide", ",", "lansoprazole", ",", "and", "C0000598#ent", "<e2>", "are", "associated", "with", "lymphocytic", "colitis"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000598", "name": "C0000598#ent", "pos": [10, 11]}}
{"token": ["Today", ",", "more", "than", "60", "mutations", "in", "the", "C0015527#ent", "<e1>", "B-subunit", "genes", "are", "known", "leading", "to", "C0019069#ent", "<e2>"], "h": {"id": "C0015527", "name": "C0015527#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [16, 17]}}
{"token": ["Deletion", "of", "the", "C1413190#ent", "<e1>", "for", "a", "C0812327#ent", "<e2>", "impaired", "ADH2", "expression", "without", "affecting", "chromatin", "remodeling"], "h": {"id": "C1413190", "name": "C1413190#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [7, 8]}}
{"token": ["In", "these", "experiments", "C0023530#ent", "<e1>", "induced", "by", "C0025241#ent", "<e2>", "did", "not", "prevent", "the", "in", "vivo", "of", "LPS", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [7, 8]}}
{"token": ["All", "children", "developed", "a", "profound", "C0023530#ent", "<e1>", "and", "thrombocytopenia", "following", "high", "dose", "C0025241#ent", "<e2>", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [12, 13]}}
{"token": ["Half", "of", "all", "patients", "with", "C1418724#ent", "<e1>", "will", "develop", "C0008370#ent", "<e2>", ",", "termed", "portal", "biliopathy", ",", "and", "some", "will", "progress", "to", "symptomatic", "biliary", "obstruction"], "h": {"id": "C1418724", "name": "C1418724#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008370", "name": "C0008370#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "inhibition", "studies", "demonstrated", "that", "the", "optimal", "induction", "of", "C0162508#ent", "<e1>", "mRNA", "in", "response", "to", "oxidative", "signals", "required", "C1705341#ent", "<e2>", "as", "well", "as", "protein", "kinase", "C", "PKC", ")", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [19, 20]}}
{"token": ["In", "conclusion", ",", "C0074554#ent", "<e1>", "selectively", "decreases", "IFN-gamma-induced", "C0017349#ent", "<e2>", "expression", "in", "human", "primary", "endothelial", "cells", "actions", "on", "the", "CIITA", "promoter", "IV"], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017349", "name": "C0017349#ent", "pos": [8, 9]}}
{"token": ["Using", "RNAse", "protection", "assay", "flow", "cytometry", "we", "observed", "that", "C0074554#ent", "<e1>", "dose-dependently", "reduced", "interferon-gamma", "(", "IFN-gamma", ")", "induced", "C0017349#ent", "<e2>", "expression", "(", "mRNA", "and", "protein", ")", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017349", "name": "C0017349#ent", "pos": [18, 19]}}
{"token": ["Glycogen", "storage", "disease", "type", "1a", "GSD", "1a", ")", "is", "an", "autosomal", "C0017361#ent", "<e1>", "metabolic", "disorder", "by", "a", "deficiency", "in", "C0017755#ent", "<e2>", "(", "G6Pase", ")", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [19, 20]}}
{"token": ["Modification", "of", "histidine", "residues", "of", "C1417943#ent", "<e1>", "results", "in", "complete", "inactivation", "of", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C1417943", "name": "C1417943#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["The", "protective", "effect", "C1417943#ent", "<e1>", "substrate", "and", "its", "analogs", "on", "the", "C0014442#ent", "<e2>", "inactivation", "by", "diethylpyrocarbonate", "was", "studied", "."], "h": {"id": "C1417943", "name": "C1417943#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["Lipoprotein", "lipase", "bovine", "milk", "stoichiometrically", "with", "diisopropylphosphorofluoridate", "(", "DFP", ")", ",", "an", "C1422492#ent", "<e1>", "of", "serine", "esterases", "resulting", "in", "the", "loss", "of", "enzymatic", "activity", "C0017860#ent", "<e2>", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [24, 25]}}
{"token": ["Protein", "kinase", "Calpha", "PKCalpha", ")", "has", "been", "shown", "to", "contain", "two", "discrete", "C1422492#ent", "<e1>", "differing", "binding", "affinities", "for", "phorbol", "esters", "C0017860#ent", "<e2>", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [20, 21]}}
{"token": ["In", "the", "present", "study", ",", "the", "effects", "of", "cartilage-derived", "factor", "C1706546#ent", "<e1>", ")", "were", "compared", "with", "those", "of", "multiplication-stimulating", "activity", "C0000294#ent", "<e2>", ")", ",", "which", "is", "thought", "to", "be", "included", "in", "somatomedins", "."], "h": {"id": "C1706546", "name": "C1706546#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000294", "name": "C0000294#ent", "pos": [20, 21]}}
{"token": ["These", "data", "imply", "that", "C0812307#ent", "<e1>", "is", "involved", "in", "B", "cell", "by", "C1413221#ent", "<e2>", "IL-5", "for", "isotype", "switching", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413221", "name": "C1413221#ent", "pos": [12, 13]}}
{"token": ["C0812307#ent", "<e1>", "is", "upstream", "of", "Btk", "activation", "in", "the", "C1413221#ent", "<e2>"], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413221", "name": "C1413221#ent", "pos": [9, 10]}}
{"token": ["When", "the", "coding", "region", "the", "C0030016#ent", "<e1>", "was", "placed", "between", "the", "C0001942#ent", "<e2>", "and", "the", "terminator", "of", "the", "expression", "vector", ",", "the", "expression", "level", "was", "32", "times", "higher", "than", "at", "the", "endogenous", "level", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [11, 12]}}
{"token": ["Gal4(BD)-p30(II)-mediated", "transactivation", "was", "enhanced", "following", "exogenous", "expression", "of", "p300", "and", "was", "competitively", "repressed", "by", "the", "C1333336#ent", "<e1>", "adenovirus", "E1A", ",", "and", "E1ACR2", "(", "mutated", "for", "C2718312#ent", "<e2>", "retaining", "p300", "binding", ")", "."], "h": {"id": "C1333336", "name": "C1333336#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2718312", "name": "C2718312#ent", "pos": [25, 26]}}
{"token": ["Furthermore", ",", "it", "was", "demonstrated", "that", "the", "stimulation", "of", "C1705159#ent", "<e1>", "activity", "by", "C1412477#ent", "<e2>", "the", "inhibition", "of", "activity", "by", "1", "M", "NaCl", "originate", "in", "structural", "features", "the", "NH2-terminal", "domain", "."], "h": {"id": "C1705159", "name": "C1705159#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412477", "name": "C1412477#ent", "pos": [13, 14]}}
{"token": ["The", "typical", "C0332601#ent", "<e1>", "not", "always", "present", "during", "C0001622#ent", "<e2>", "."], "h": {"id": "C0332601", "name": "C0332601#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [8, 9]}}
{"token": ["To", "study", "C0070043#ent", "<e1>", "PANK2", ")", "gene", "mutations", "Chinese", "patients", "with", "Hallervorden-Spatz", "syndrome", "C0018522#ent", "<e2>", ")", "."], "h": {"id": "C0070043", "name": "C0070043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018522", "name": "C0018522#ent", "pos": [13, 14]}}
{"token": ["Western", "blot", "analysis", "the", "cytoplasm", "fractions", "using", "an", "C1415638#ent", "<e1>", "antibody", "revealed", "that", "these", "two", "proteins", "are", "C0534519#ent", "<e2>", "C1415638#ent", "<e1>", "and", "p42", "C1415638#ent", "<e1>", "."], "h": {"id": "C1415638", "name": "C1415638#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [17, 18]}}
{"token": ["The", "spread", "of", "C1334122#ent", "<e1>", "to", "the", "circulation", "in", "patients", "with", "C0520575#ent", "<e2>", "contribute", "to", "the", "elevation", "of", "fever", "and", "C-reactive", "protein", "of", "the", "disease", "."], "h": {"id": "C1334122", "name": "C1334122#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0520575", "name": "C0520575#ent", "pos": [11, 12]}}
{"token": ["The", "hallmarks", "of", "rheumatic", "fever", "arthritis", ",", "carditis", ",", "cutaneous", "disease", "C0152113#ent", "<e1>", ",", "and", "subsequent", "acquired", "C0026265#ent", "<e2>"], "h": {"id": "C0152113", "name": "C0152113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026265", "name": "C0026265#ent", "pos": [17, 18]}}
{"token": ["Some", "infections", "of", "the", "central", "nervous", "system", "C0014038#ent", "<e1>", "of", "unknown", "aetiology", ",", "cytomegalic", "encephalitis", ",", "C0025289#ent", "<e2>", ")", "may", "show", "cerebral", "atrophy", "even", "no", "morphological", "changes", "."], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [16, 17]}}
{"token": ["Clinical", "presentations", "this", "wide", "spectrum", ",", "with", "C0014038#ent", "<e1>", "primarily", "characterized", "by", "altered", "mental", "status", "C0025289#ent", "<e2>", "by", "fever", ",", "headache", ",", "and", "neck", "stiffness", "and", "brain", "abscess", "localizing", "findings", "."], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [15, 16]}}
{"token": ["Also", ",", "C1825620#ent", "<e1>", "(", "100", "microM", ")", ",", "like", "40", "microM", "C0007044#ent", "<e2>", "significantly", "reduced", "the", "rhodamine", "123", "uptake", "by", "GC3/c1", "cells", "studied", "by", "flow", "cytometry"], "h": {"id": "C1825620", "name": "C1825620#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007044", "name": "C0007044#ent", "pos": [12, 13]}}
{"token": ["Immunohistochemistry", "for", "tyrosine", "hydroxylase", "C4285344#ent", "<e1>", ")", "was", "performed", "on", "the", "dorsal", "root", "ganglia", "DRG", ")", "in", "C2987364#ent", "<e2>", ",", "heterozygous", "and", "Brn-3a", "knockout", "mice", "embryonic", "day", "."], "h": {"id": "C4285344", "name": "C4285344#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [17, 18]}}
{"token": ["SMRT", "was", "3-fold", "increased", "in", "C4285344#ent", "<e1>", "treatment", "of", "only", "C2987364#ent", "<e2>", "mouse", "pups", "."], "h": {"id": "C4285344", "name": "C4285344#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}}
{"token": ["The", "resulting", "generation", "of", "C0017789#ent", "<e1>", "participates", "in", "C0081888#ent", "<e2>", "exocytosis", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0081888", "name": "C0081888#ent", "pos": [8, 9]}}
{"token": ["Common", "to", "all", "eukaryotes", ",", "C0085139#ent", "<e1>", "are", "cytoskeletal", "motor", "proteins", "mediate", "intracellular", "transport", "on", "microtubule", "tracks", "using", "C1705556#ent", "<e2>", "hydrolysis", "."], "h": {"id": "C0085139", "name": "C0085139#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [18, 19]}}
{"token": ["The", "authors", "conclude", "that", "these", "represent", "two", "distinct", "C0012634#ent", "<e1>", "and", "that", "UDSSC", "may", "be", "a", "vesicular", "form", "of", "C0024140#ent", "<e2>", "in", "the", "adult", "rough", "collie", "dog", "Shetland", "sheepdog"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024140", "name": "C0024140#ent", "pos": [19, 20]}}
{"token": ["This", "study", "investigated", "C0206061#ent", "<e1>", "associated", "with", "amyopathic", "dermatomyositis", "dermatomyositis", "and", "C0011633#ent", "<e2>", ",", "paying", "particular", "attention", "to", "muscular", "and/or", "cutaneous", "manifestations", "and", "their", "chronology", "relative", "to", "lung", "involvement", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011633", "name": "C0011633#ent", "pos": [11, 12]}}
{"token": ["C0206061#ent", "<e1>", "IP", ")", "is", "a", "serious", "complication", "in", "C0011633#ent", "<e2>", "(", "PM/DM", ")", ",", "leading", "to", "significant", "morbidity", "or", "mortality", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011633", "name": "C0011633#ent", "pos": [9, 10]}}
{"token": ["Niacin-ER", "had", "a", "greater", "effect", "in", "raising", "HDL-C", "and", "C1412468#ent", "<e1>", "levels", "than", "did", "C1567533#ent", "<e2>", "."], "h": {"id": "C1412468", "name": "C1412468#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1567533", "name": "C1567533#ent", "pos": [14, 15]}}
{"token": ["C1412468#ent", "<e1>", "unchanged", ",", "but", "A-II", "increased", "by", "20", "%", "during", "C1567533#ent", "<e2>", "treatment", "."], "h": {"id": "C1412468", "name": "C1412468#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1567533", "name": "C1567533#ent", "pos": [11, 12]}}
{"token": ["The", "most", "potent", "converting", "enzyme", "inhibitors", "C0002570#ent", "<e1>", "the", "carboxylalkyl", "compounds", ",", "C0055724#ent", "<e2>", ",", "enalaprilat", ",", "and", "ramiprilat", "(", "I50", "values", "of", "3", "-", "12", "microM", ")", "."], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0055724", "name": "C0055724#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "C1422163#ent", "<e1>", "interacts", "with", "the", "C1421536#ent", "<e2>", "in", "female", "human", "and", "mouse", "cells"], "h": {"id": "C1422163", "name": "C1422163#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421536", "name": "C1421536#ent", "pos": [7, 8]}}
{"token": ["Additionally", ",", "an", "inhibitor", "of", "p44/p42", "mitogen-activated", "protein", "kinase", "C0298346#ent", "<e1>", ")", "significantly", "inhibited", "sPLA2-induced", "C1333931#ent", "<e2>", "activation", "and", "AA", "release", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333931", "name": "C1333931#ent", "pos": [15, 16]}}
{"token": ["Further", ",", "using", "MEK1", "inhibitor", "C0298346#ent", "<e1>", "we", "showed", "that", "leptin", "activates", "C1333931#ent", "<e2>", "through", "ERK", "induction", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333931", "name": "C1333931#ent", "pos": [12, 13]}}
{"token": ["In", "C0002395#ent", "<e1>", "AD", ")", ",", "increased", "nitric", "oxide", "synthase", "3", "C1328053#ent", "<e2>", ")", "expression", "correlates", "with", "apoptosis", "in", "cortical", "neurons", "and", "colocalizes", "with", "amyloid", "precursor", "protein", "beta", "(", "Abeta", ")", "deposits", "in", "the", "brain", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [1, 2]}, "relation": "disease_has_associated_gene", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [11, 12]}}
{"token": ["The", "Na", ",", "K-ATPase", ",", "an", "oligomeric", "P-type", "adenosine", "triphosphatase", "C0001473#ent", "<e1>", ")", ",", "is", "composed", "of", "a", "catalytic", "alpha", "subunit", "a", "C3537330#ent", "<e2>", "is", "the", "main", "player", "that", "fulfils", "these", "tasks", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3537330", "name": "C3537330#ent", "pos": [22, 23]}}
{"token": ["The", "Na", ",", "K-ATPase", ",", "an", "oligomeric", "C0001473#ent", "<e1>", "ATPase", ")", ",", "is", "composed", "of", "a", "catalytic", "alpha", "subunit", "a", "C3537330#ent", "<e2>", "is", "the", "main", "player", "that", "fulfils", "these", "tasks", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537330", "name": "C3537330#ent", "pos": [20, 21]}}
{"token": ["Phase-shifts", "by", "C0394006#ent", "<e1>", "can", "not", "be", "interpreted", "as", "evidence", "that", "plasma", "membrane", "C1706373#ent", "<e2>", "is", "a", "component", "of", "the", "circadian", "clock"], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [13, 14]}}
{"token": ["Results", "from", "the", "radiologic", "study", "that", "C0059865#ent", "<e1>", "not", "only", "prevented", "the", "further", "development", "of", "articular", "damage", "C0029408#ent", "<e2>", "but", "actually", "caused", "a", "regression", "of", "these", "lesions", "established", "before", "drug", "treatment", "."], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [17, 18]}}
{"token": ["The", "efficacy", "and", "tolerability", "of", "C0059865#ent", "<e1>", "and", "piroxicam", "were", "compared", "in", "patients", "with", "C0029408#ent", "<e2>", "of", "the", "knee", "."], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [14, 15]}}
{"token": ["Because", "the", "reaction", "catalysed", "by", "CCS", "corresponds", "to", "the", "first", "half", "of", "that", "mediated", "by", "C1412125#ent", "<e1>", ",", "CCS", "may", "be", "responsible", "for", "C3815504#ent", "<e2>", "H.", "thermophilus"], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3815504", "name": "C3815504#ent", "pos": [23, 24]}}
{"token": ["In", "this", "study", ",", "we", "found", "that", "C1538714#ent", "<e1>", "alters", "expression", "of", "the", "C0079419#ent", "<e2>", "Beas2B", "airway", "epithelial", "cells", "both", "a", "time-", "and", "concentration-dependent", "manner", "."], "h": {"id": "C1538714", "name": "C1538714#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079419", "name": "C0079419#ent", "pos": [13, 14]}}
{"token": ["Their", "relative", "potencies", "to", "form", "a", "complex", "with", "uncoupler", "have", "followed", "the", "order", ":", "procaine", "<", "C0041026#ent", "<e1>", "<", "tetracaine", "<", "dibucaine", "<", "dodecylamine", "<", "C0057893#ent", "<e2>", "<", "hexadecylamine", "."], "h": {"id": "C0041026", "name": "C0041026#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0057893", "name": "C0057893#ent", "pos": [25, 26]}}
{"token": ["The", "defect", "in", "C0272236#ent", "<e1>", "intrinsic", "to", "B", "cells", "which", "fail", "to", "switch", "from", "C1706005#ent", "<e2>", "to", "IgG", "synthesis", "."], "h": {"id": "C0272236", "name": "C0272236#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [14, 15]}}
{"token": ["C0272236#ent", "<e1>", "XHIM", ")", "is", "a", "severe", "congenital", "immunodeficiency", "by", "mutations", "in", "C1706005#ent", "<e2>", "(", "CD40", "ligand", ",", "gp39", ")", ",", "the", "T", "cell", "for", "CD40", "on", "B", "cells"], "h": {"id": "C0272236", "name": "C0272236#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [12, 13]}}
{"token": ["To", "identify", "C0872913#ent", "<e1>", "and/or", "cross-reactive", "B-cell", "of", "P.", "gingivalis", "human", "heat-shock", "protein", "in", "C0003850#ent", "<e2>", "patients", ",", "we", "synthesized", "104", "overlapping", "synthetic", "peptides", "whole", "molecules", "of", "P.", "gingivalis", "HSP60", "and", "human", "HSP60", ",", "respectively", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [14, 15]}}
{"token": ["We", "considered", "that", "there", "are", "no", "enough", "dates", "to", "one", "valued", "estimation", "of", "possible", "role", "of", "polymorphisms", "of", "PAI-1", "and", "C0872913#ent", "<e1>", "genes", "in", "pathogenesis", "of", "C0003850#ent", "<e2>", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [26, 27]}}
{"token": ["Each", "volunteer", "received", "single", "oral", "doses", "15", "mg", "C0026056#ent", "<e1>", "on", "four", "separate", "occasions", ":", "8", "C1426677#ent", "<e2>", ",", "2", "PM", ",", "8", "PM", ",", "and", "2", "C1426677#ent", "<e2>", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1426677", "name": "C1426677#ent", "pos": [16, 17]}}
{"token": ["Antisera", "recognizing", "rat", "UGT1A1", "and", "C3537334#ent", "<e1>", "were", "used", "to", "assess", "C1420188#ent", "<e2>", "levels", "in", "relation", "to", "C1420188#ent", "<e2>", "activity", "towards", "benzo[a]pyrene-7,8-dihydrodiol", "(", "BPD", ")", "."], "h": {"id": "C3537334", "name": "C3537334#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420188", "name": "C1420188#ent", "pos": [11, 12]}}
{"token": ["To", "overcome", "this", "problem", ",", "we", "used", "a", "C0001486#ent", "<e1>", "Ad5/35-TRAIL", ")", "to", "induce", "apoptosis", "in", "a", "C4025289#ent", "<e2>", "and", "multidrug-resistant", "variant", "HL-60", "leukemia", "cells", "and", "determined", "the", "molecular", "mechanisms", "Ad5/35-TRAIL-induced", "apoptosis", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4025289", "name": "C4025289#ent", "pos": [17, 18]}}
{"token": ["We", "conducted", "a", "double", "blind", "controlled", "trial", "28", "C0013264#ent", "<e1>", "DMD", ")", "patients", "with", "C0057258#ent", "<e2>", "(", "DF", ")", ",", "an", "oxazoline", "derivative", "of", "prednisolone", "which", "reduces", "its", "side-effects", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0057258", "name": "C0057258#ent", "pos": [14, 15]}}
{"token": ["A", "randomized", "double-blind", "controlled", "trial", "C0057258#ent", "<e1>", "was", "conducted", "in", "28", "C0013264#ent", "<e2>", "patients", "either", "treated", "with", "C0057258#ent", "<e1>", "2.0", "mg/kg", "alternate-day", "therapy", "or", "placebo", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0057258", "name": "C0057258#ent", "pos": [5, 6]}}
{"token": ["The", "effect", "of", "autologous", "transplantation", "the", "superior", "cervical", "ganglion", "C0012694#ent", "<e1>", ")", "into", "the", "brain", "of", "C0242422#ent", "<e2>", "monkeys", "was", "studied", "through", "quantitative", "measurement", "of", "animal", "behavior"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [16, 17]}}
{"token": ["Many", "angiographers", "believe", "that", "C0042071#ent", "<e1>", "an", "unusually", "effective", "plasminogen", "activator", "the", "setting", "of", "resistant", "C0010072#ent", "<e2>"], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0010072", "name": "C0010072#ent", "pos": [15, 16]}}
{"token": ["The", "Bardet-Biedl", "syndrome", "a", "rare", "autosomal", "recessive", "disorder", "by", "C0796072#ent", "<e1>", "obesity", ",", "polydactyly", ",", "C0151721#ent", "<e2>", ",", "and", "mental", "retardation"], "h": {"id": "C0796072", "name": "C0796072#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151721", "name": "C0151721#ent", "pos": [15, 16]}}
{"token": ["This", "article", "reviews", "several", "autosomal", "recessive", "syndromes", "by", "C0796072#ent", "<e1>", ",", "in", "many", ",", "combined", "with", "deafness", ",", "C0151721#ent", "<e2>", ",", "and/or", "mental", "retardation"], "h": {"id": "C0796072", "name": "C0796072#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0151721", "name": "C0151721#ent", "pos": [18, 19]}}
{"token": ["Alstr\u00f6m", "syndrome", "is", "an", "autosomal", "recessive", "disorder", "of", "progressive", "vision", "loss", "(", "nystagmus", ",", "photophobia", ",", "and", "C0796072#ent", "<e1>", ",", "progressive", "sensorineural", "hearing", "loss", "morbid", "obesity", "male", "C0151721#ent", "<e2>", ",", "insulin", "resistant", "diabetes", "renal", "failure", "and", "dilated", "cardiomyopathy"], "h": {"id": "C0796072", "name": "C0796072#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0151721", "name": "C0151721#ent", "pos": [27, 28]}}
{"token": ["In", "dogs", "with", "gastric", "fistulae", "Heidenhain", "pouches", ",", "inhibition", "of", "histamine-stimulated", "gastric", "acid", "secretion", "by", "the", "histamine", "H2-receptor", "antagonist", "C0025845#ent", "<e1>", "is", "not", "increased", "by", "the", "addition", "of", "a", "C0019590#ent", "<e2>", "mepyramine", "maleate", ")", "."], "h": {"id": "C0025845", "name": "C0025845#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0019590", "name": "C0019590#ent", "pos": [29, 30]}}
{"token": ["The", "activity", "of", "the", "non-stimulated", ",", "basal", "adenylate", "cyclase", "the", "dog", "gastric", "mucosa", "reduced", "by", "the", "histamine", "H2-receptor", "antagonist", "C0025845#ent", "<e1>", "but", "not", "by", "the", "C0019590#ent", "<e2>"], "h": {"id": "C0025845", "name": "C0025845#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0019590", "name": "C0019590#ent", "pos": [25, 26]}}
{"token": ["C0025387#ent", "<e1>", "is", "an", "opioid", "partial", "C0243192#ent", "<e2>", "with", "a", "potency", "at", "a", "dose", "of", "100", "mg", "similar", "to", "that", "of", "pethidine", ",", "but", "with", "a", "faster", "onset", "and", "shorter", "duration", "of", "action", "."], "h": {"id": "C0025387", "name": "C0025387#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [6, 7]}}
{"token": ["In", "recent", "months", ",", "there", "has", "been", "a", "rapid", "growth", "in", "the", "number", "of", "C0796254#ent", "<e1>", "cycles", "utilizing", "one", "such", "method", ",", "comparative", "genomic", "hybridization", "C1866260#ent", "<e2>", ")", "."], "h": {"id": "C0796254", "name": "C0796254#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1866260", "name": "C1866260#ent", "pos": [25, 26]}}
{"token": ["This", "effect", "can", "be", "prevented", "by", "incubation", "of", "the", "cells", "with", "the", "protease", "inhibitor", "C0064858#ent", "<e1>", ",", "which", "suggests", "that", "desipramine", "induces", "proteolytic", "degradation", "the", "C0391845#ent", "<e2>"], "h": {"id": "C0064858", "name": "C0064858#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [25, 26]}}
{"token": ["C0078844#ent", "<e1>", "is", "an", "C0003299#ent", "<e2>", "and", "first", "marketed", "in", "Japan", "in", "1989", "."], "h": {"id": "C0078844", "name": "C0078844#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [4, 5]}}
{"token": ["Fractions", "containing", "predominantly", "FSH", "or", "C1538681#ent", "<e1>", "activity", "were", "isolated", "from", "the", "C0072522#ent", "<e2>"], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}}
{"token": ["Bilateral", "focal", "TMS", "delivered", "over", "C0812443#ent", "<e1>", "disrupted", "the", "discrimination", "of", "C0651679#ent", "<e2>", "in", "a", "time", "window", "20", "-", "40", "ms", "later", "than", "the", "effect", "of", "TMS", "delivered", "over", "occipital", "cortex"], "h": {"id": "C0812443", "name": "C0812443#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0651679", "name": "C0651679#ent", "pos": [11, 12]}}
{"token": ["No", "adverse", "effects", "the", "C0771711#ent", "<e1>", "were", "detected", "from", "the", "C1420583#ent", "<e2>", ",", "including", "the", "provision", "of", "intravenous", "(IV)", "fat"], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420583", "name": "C1420583#ent", "pos": [10, 11]}}
{"token": ["BIBX1382", "[", "N8-(3-chloro-4-fluoro-phenyl)-N2-(1-methyl-piperidin-4-yl)-pyrimido[5,4-d]pyrimidine-2,8-diamine", "]", "and", "BIBU1361", "[", "(3-chloro-4-fluoro-phenyl)-[6-(4-diethylaminomethyl-piperidin-1yl)-pyrimido[5,4-d]pyrimidin-4-yl]-amine", "]", "are", "two", "new", "selective", "C3537035#ent", "<e1>", "do", "not", "block", "the", "activity", "of", "other", "C1421249#ent", "<e2>"], "h": {"id": "C3537035", "name": "C3537035#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [22, 23]}}
{"token": ["The", "first", "drug", "evaluated", "was", "C0087097#ent", "<e1>", "(", "1-methyl-5-p-toluoylpyrrole-2", "acetic", "acid", ",", "a", "new", "C0003211#ent", "<e2>"], "h": {"id": "C0087097", "name": "C0087097#ent", "pos": [5, 6]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [14, 15]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "investigate", "sex-related", "differences", "the", "pharmacokinetics", "of", "C0087097#ent", "<e1>", ",", "a", "potent", "C0003211#ent", "<e2>", "in", "the", "rat", "."], "h": {"id": "C0087097", "name": "C0087097#ent", "pos": [13, 14]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [18, 19]}}
{"token": ["Also", ",", "in", "the", "Randomized", "Aldactone", "Evaluation", "Study", "C0037982#ent", "<e1>", "coadministered", "with", "conventional", "therapy", "C0003015#ent", "<e2>", "loop", "diuretics", "digitalis", "in", "patients", "with", "symptomatic", "heart", "failure", "as", "NYHA", "classes", "reduces", "total", "mortality", "by", "30", "%", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [14, 15]}}
{"token": ["New", "developments", "in", "the", "drug", "treatment", "heart", "failure", "the", "possible", "addition", "of", "beta-blockers", "or", "C0037982#ent", "<e1>", "to", "diuretic", "and", "C0003015#ent", "<e2>", "therapy", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [19, 20]}}
{"token": ["At", "present", ",", "the", "legal", "requirements", "France", "state", "\"", "the", "association", "of", "C0037982#ent", "<e1>", "and", "converting", "enzyme", "inhibitors", "possible", "with", "low", "doses", "C0003015#ent", "<e2>", "diuretic", "hypokalaemiant", "kalaemia", "and", "creatinine", "have", "to", "be", "monitored", "\"", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [22, 23]}}
{"token": ["Potential", "therapies", "for", "the", "C0035334#ent", "<e1>", "associated", "with", "abetalipoproteinemia", "and", "C0282527#ent", "<e2>", "also", "considered", "."], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0282527", "name": "C0282527#ent", "pos": [10, 11]}}
{"token": ["Sera", "from", "patients", "suffering", "from", "C0751871#ent", "<e1>", "as", "systemic", "lupus", "erythematosus", "SLE", ")", "and", "C0036421#ent", "<e2>", "SSc", ")", "have", "been", "shown", "to", "contain", "reactivities", "to", "nuclear", "components"], "h": {"id": "C0751871", "name": "C0751871#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [14, 15]}}
{"token": ["Several", "studies", "have", "demonstrated", "abnormalities", "of", "T", "cell", "regulation", "Epstein-Barr", "virus-induced", "B", "cell", "in", "C0751871#ent", "<e1>", "as", "rheumatoid", "arthritis", "systemic", "lupus", "erythematous", "and", "C0036421#ent", "<e2>"], "h": {"id": "C0751871", "name": "C0751871#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [23, 24]}}
{"token": ["C0011777#ent", "<e1>", "treatment", "prevented", "the", "development", "of", "C0525678#ent", "<e2>", "and", "decreased", "the", "CXC", "chemokine", "mRNA", "expression", "in", "the", "lung", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [7, 8]}}
{"token": ["A", "clinical", "trial", "conducted", "in", "Argentina", "to", "determine", "the", "efficacy", "of", "clarithromycin", "plus", "C0050940#ent", "<e1>", "for", "the", "treatment", "of", "Helicobacter", "pylori", "C0013295#ent", "<e2>", "non-ulcer", "dyspepsia"], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [21, 22]}}
{"token": ["Maintenance", "therapy", "C0050940#ent", "<e1>", "15", "mg/day", "suppresses", "acid", "and", "controls", "recurrence", "of", "C0013295#ent", "<e2>"], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [12, 13]}}
{"token": ["Hamsters", "experimentally", "inoculated", "with", "C0036457#ent", "<e1>", "had", "histologic", "and", "ultrastructural", "changes", "their", "retinas", "before", "clinical", "signs", "C0348165#ent", "<e2>", "evident", "at", "50", "days", "postinoculation", "."], "h": {"id": "C0036457", "name": "C0036457#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0348165", "name": "C0348165#ent", "pos": [16, 17]}}
{"token": ["C0022252#ent", "<e1>", "dinitrate", "effectively", "reduces", "left", "ventricular", "filling", "pressure", "the", "resting", "patient", "with", "C0018802#ent", "<e2>", "produces", "a", "more", "comprehensive", "improvement", "in", "left", "ventricular", "performance", "exercise", "."], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["Parallel", "to", "this", "increased", "expression", "of", "C0087140#ent", "<e1>", "an", "activation", "of", "the", "ornithine", "decarboxylase", "ODC", ")", "gene", "and", "C0027203#ent", "<e2>", "was", "also", "observed", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["Phenotype", "results", "showed", "that", "CYP2D6", "inhibition", "in", "patients", "treated", "with", "C0074393#ent", "<e1>", "appeared", "to", "be", "related", "to", "baseline", "C1332830#ent", "<e2>", "C0074393#ent", "<e1>", "dosage", "."], "h": {"id": "C0074393", "name": "C0074393#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332830", "name": "C1332830#ent", "pos": [18, 19]}}
{"token": ["The", "pharmacokinetics", "of", "desipramine", "when", "coadministered", "with", "the", "selective", "serotonin", "reuptake", "inhibitors", "SSRIs", ")", "paroxetine", "and", "C0074393#ent", "<e1>", "were", "studied", "in", "24", "healthy", "male", "volunteers", "(", "C1332830#ent", "<e2>", "extensive", "metabolizers", ")", "."], "h": {"id": "C0074393", "name": "C0074393#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332830", "name": "C1332830#ent", "pos": [26, 27]}}
{"token": ["However", ",", "AHO", "may", "be", "associated", "with", "hormone", "resistance", "C3494506#ent", "<e1>", "PHPIa", ")", "or", "a", "normal", "response", "pseudo-pseudohypoparathyroidism", ",", "C0033835#ent", "<e2>", ")", "."], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0033835", "name": "C0033835#ent", "pos": [19, 20]}}
{"token": ["Activation", "of", "T", "cells", "associated", "with", "accumulation", "of", "signaling", "proteins", "C3540529#ent", "<e1>", "rafts", "--", "microdomains", "of", "the", "plasma", "membrane", "in", "cholesterol", "and", "C0017978#ent", "<e2>", "."], "h": {"id": "C3540529", "name": "C3540529#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017978", "name": "C0017978#ent", "pos": [22, 23]}}
{"token": ["The", "interaction", "of", "C1421210#ent", "<e1>", "with", "C1453024#ent", "<e2>", "decreases", "the", "catalytic", "activity", "C1421210#ent", "<e1>", "with", "respect", "to", "thiocyanate", "formation"], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421210", "name": "C1421210#ent", "pos": [3, 4]}}
{"token": ["A", "search", "for", "more", "effective", "serotonin", "antagonists", "without", "the", "C0242896#ent", "<e1>", "and", "antihistaminic", "side", "effects", "of", "C0354872#ent", "<e2>", "is", "needed", "and", "is", "in", "process", "."], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0354872", "name": "C0354872#ent", "pos": [16, 17]}}
{"token": ["In", "situ", "hybridization", "that", ",", "spatially", ",", "C1367460#ent", "<e1>", "is", "expressed", "in", "a", "pattern", "similar", "to", "the", "Arabidopsis", "C1416970#ent", "<e2>", "that", "ATS3", "is", "expressed", "in", "a", "pattern", "similar", "to", "the", "Arabidopsis", "seed", "storage", "protein", "genes"], "h": {"id": "C1367460", "name": "C1367460#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416970", "name": "C1416970#ent", "pos": [18, 19]}}
{"token": ["The", "patients", "suffered", "from", "various", "C0022658#ent", "<e1>", "including", "glomerulonephritis", ",", "obstructive", "uropathy", "C0034186#ent", "<e2>", "nephrosclerosis", "and", "chronic", "nephropathy", "undetermined", "nature", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [12, 13]}}
{"token": ["Dynamic", "scintigraphy", "employed", "in", "studying", "of", "uteroplacental", "blood", "flow", "in", "75", "pregnant", "females", "variety", "of", "C0022658#ent", "<e1>", "severity", "and", "duration", "developing", "presence", "of", "C0034186#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [23, 24]}}
{"token": ["The", "SS", "also", "were", "negative", "for", "C1367597#ent", "<e1>", "(", "AFP", ")", ",", "beta-human", "chorionic", "gonadotropin", "hCG", ")", ",", "and", "C1870006#ent", "<e2>", "LCA", ")", "."], "h": {"id": "C1367597", "name": "C1367597#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [19, 20]}}
{"token": ["The", "obesogenous", "effects", "of", "C3273279#ent", "<e1>", "feeding", "over", "generations", "may", "be", "associated", "with", "C1416902#ent", "<e2>", "leptin", "gene", "expression", "on", "rat", "adipose", "tissues"], "h": {"id": "C3273279", "name": "C3273279#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [13, 14]}}
{"token": ["A", "C0079429#ent", "<e1>", "encoding", "a", "putative", "translational", "elongation", "factor", "3", "C1709810#ent", "<e2>", ")", "on", "the", "genome", "of", "Chlorella", "virus", "has", "been", "cloned", "and", "sequenced", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1709810", "name": "C1709810#ent", "pos": [10, 11]}}
{"token": ["For", "the", "immunocytochemistry", ",", "antibodies", "to", "C0054314#ent", "<e1>", "GABA", ")", ",", "glutamic", "acid", "decarboxylase", "GAD", ")", ",", "C1419140#ent", "<e2>", ",", "calbindin", ",", "tyrosine", "hydroxylase", "somatostatin", ",", "serotonin", "and", "glutamate", "were", "used", "."], "h": {"id": "C0054314", "name": "C0054314#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419140", "name": "C1419140#ent", "pos": [17, 18]}}
{"token": ["Serum", "immunoelectrophoretic", "and", "electrophoretic", "data", "--", "increase", "of", "IgG", "and", "C1706005#ent", "<e1>", ",", "decrease", "of", "IgA", "and", "C0154254#ent", "<e2>", "--", "point", "to", "a", "possible", "autoimmune", "mechanism", "the", "neuromuscular", "disorders", "our", "patients", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0154254", "name": "C0154254#ent", "pos": [17, 18]}}
{"token": ["On", "the", "other", "hand", ",", "the", "transfer", "of", "NZW", "pre-B", "cell", "lines", "to", "moderately", "elevated", "C1706005#ent", "<e1>", "levels", "and", "marked", "C0154254#ent", "<e2>", "of", "IgG2a", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0154254", "name": "C0154254#ent", "pos": [20, 21]}}
{"token": ["The", "reversibility", "of", "the", "C0151517#ent", "<e1>", "the", "diagnosis", "'", "C0275778#ent", "<e2>", "secondary", "AV", "block", ",", "and", "the", "pacemaker", "was", "explanted", "."], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0275778", "name": "C0275778#ent", "pos": [9, 10]}}
{"token": ["Papillary", "thyroid", "carcinoma", "PTC", ")", "is", "frequently", "associated", "with", "C0694890#ent", "<e1>", "that", "generate", "the", "so-called", "C1865982#ent", "<e2>"], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [9, 10]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1865982", "name": "C1865982#ent", "pos": [15, 16]}}
{"token": ["C0694890#ent", "<e1>", ",", "which", "generate", "chimeric", "C1865982#ent", "<e2>", "are", "early", "events", "the", "evolution", "of", "thyroid", "papillary", "carcinomas"], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [0, 1]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1865982", "name": "C1865982#ent", "pos": [6, 7]}}
{"token": ["The", "most", "frequent", "genetic", "alterations", "thus", "far", "in", "human", "papillary", "thyroid", "carcinomas", "somatic", "rearrangements", "the", "C0694890#ent", "<e1>", "which", "generate", "the", "chimeric", "C1865982#ent", "<e2>"], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [15, 16]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1865982", "name": "C1865982#ent", "pos": [21, 22]}}
{"token": ["Several", "lines", "of", "evidence", "support", "early", "immunomodulatory", "treatment", "C0751967#ent", "<e1>", "either", "recombinant", "beta-interferons", "or", "C0289884#ent", "<e2>", "positive", "results", "from", "phase", "III", "trials", "start", "of", "treatment", "even", "in", "patients", "with", "clinical", "isolated", "syndrome", "CIS", ")", "."], "h": {"id": "C0751967", "name": "C0751967#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0289884", "name": "C0289884#ent", "pos": [14, 15]}}
{"token": ["These", "results", "support", "the", "idea", "that", "C1414814#ent", "<e1>", "facilitates", "nerve", "ending", "C0243051#ent", "<e2>", "release", "and", "phosphoinositide", "production", "PI4K", "localizes", "these", "effects", "to", "N-terminal", "of", "C1414814#ent", "<e1>", "."], "h": {"id": "C1414814", "name": "C1414814#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [11, 12]}}
{"token": ["This", "work", "tested", "the", "theory", "that", "neuronal", "calcium", "sensor-1", "C1414814#ent", "<e1>", ")", "has", "effects", "on", "C0243051#ent", "<e2>", "release", "beyond", "its", "actions", "on", "membrane", "channels"], "h": {"id": "C1414814", "name": "C1414814#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [15, 16]}}
{"token": ["Bacterial", "sinusitis", "C0024116#ent", "<e1>", "and", "obstructive", "airways", "disease", "to", "C0006274#ent", "<e2>", "are", "the", "main", "late-onset", "respiratory", "disorders"], "h": {"id": "C0024116", "name": "C0024116#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006274", "name": "C0006274#ent", "pos": [9, 10]}}
{"token": ["When", "the", "stomatal", "aperture", "was", "decreased", "by", "darkness", ",", "these", "C1420740#ent", "<e1>", "became", "twisted", "and", "C1826732#ent", "<e2>", "and", "broken", "down", "into", "diffuse", "fragments", "when", "stomata", "were", "closed", "."], "h": {"id": "C1420740", "name": "C1420740#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1826732", "name": "C1826732#ent", "pos": [15, 16]}}
{"token": ["C0000833#ent", "<e1>", "the", "most", "common", "examples", "for", "this", "procedure", ",", "although", "C0243001#ent", "<e2>", "well", "as", "pancreatic", "pseudocysts", "also", "be", "treated", "successfully", "."], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0243001", "name": "C0243001#ent", "pos": [11, 12]}}
{"token": ["Depending", "on", "how", "the", "subsequent", "inflammatory", "response", "contained", ",", "a", "C0000833#ent", "<e1>", "colonic", "narrowing", "obstruction", ",", "an", "C0243001#ent", "<e2>", "or", "a", "fistula", "may", "occur", "and", "be", "demonstrated", "on", "barium", "enema", "examination"], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0243001", "name": "C0243001#ent", "pos": [17, 18]}}
{"token": ["C0011812#ent", "<e1>", "(", "AM", ")", "and", "its", "fluorinated", "analogue", "(+)-2-amino-3-fluoro-1-phenylpropane", "(", "C0795571#ent", "<e2>", ",", "FAM", ")", "were", "compared", "with", "regard", "to", "their", "effects", "on", "locomotor", "and", "exploratory", "activity", "in", "mice", "."], "h": {"id": "C0011812", "name": "C0011812#ent", "pos": [0, 1]}, "relation": "part_of", "t": {"id": "C0795571", "name": "C0795571#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "intended", "to", "examine", "the", "role", "of", "hypothalamic", "norepinephrine", "C1414369#ent", "<e1>", ")", "and", "dopamine", "(", "C3539637#ent", "<e2>", ")", "in", "episodic", "luteinizing", "hormone", "LH", ")", "release", "in", "adult", "ovariectomized", "rats", "."], "h": {"id": "C1414369", "name": "C1414369#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539637", "name": "C3539637#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "on", "a", "nanoscale", "resolution", "using", "stimulated", "emission", "depletion", "microscopy", "and", "by", "F\u00f6rster", "resonance", "energy", "transfer", "fluorescence", "lifetime", "imaging", "microscopy", "we", "provide", "evidence", "that", "C1414638#ent", "<e1>", "promotes", "the", "clustering", "of", "C1364818#ent", "<e2>", "at", "the", "cell", "surface"], "h": {"id": "C1414638", "name": "C1414638#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [31, 32]}}
{"token": ["Of", "the", "6", "deaths", ",", "5", "had", "C3275121#ent", "<e1>", "one", "did", "not", "have", "any", "significant", "C0948480#ent", "<e2>"], "h": {"id": "C3275121", "name": "C3275121#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0948480", "name": "C0948480#ent", "pos": [15, 16]}}
{"token": ["TF", "P/M", "level", "in", "the", "patients", "with", "C3275121#ent", "<e1>", "higher", "than", "that", "in", "the", "patients", "with", "C0948480#ent", "<e2>", "single", "vessel", "disease", "double", "vessel", "disease"], "h": {"id": "C3275121", "name": "C3275121#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0948480", "name": "C0948480#ent", "pos": [16, 17]}}
{"token": ["Responses", "were", "compared", "with", "responses", "after", "ingestion", "of", "C0022957#ent", "<e1>", ",", "fructose", ",", "and", "C0037688#ent", "<e2>", "."], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [14, 15]}}
{"token": ["Plaque", "pH", "was", "monitored", "in", "12", "volunteers", "following", "rinsing", "the", "mouth", "with", "C0022957#ent", "<e1>", ",", "sucrose", "or", "C0037688#ent", "<e2>", "or", "Lactulose", "BP"], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [17, 18]}}
{"token": ["After", "C0030946#ent", "<e1>", "treatment", "to", "C0031165#ent", "<e2>", "the", "tissue", "sections", "biotinylated", "nucleotides", "in", "situ", "into", "DNA", "breaks", "polymerase", "and", "subsequently", "stained", "with", "DAB", "via", "peroxidase-conjugated", "avidin", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031165", "name": "C0031165#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "C3273406#ent", "<e1>", "blockade", "also", "significantly", "increased", "C1704823#ent", "<e2>", "production", "in", "SHR-DM", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704823", "name": "C1704823#ent", "pos": [9, 10]}}
{"token": ["Thirty", "patients", "with", "clinical", "signs", "C0040553#ent", "<e1>", ",", "20", "cases", "with", "other", "C0747256#ent", "<e2>", "and", "40", "healthy", "subjects", "tested", "."], "h": {"id": "C0040553", "name": "C0040553#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [12, 13]}}
{"token": ["A", "clinical", "score", "C0006840#ent", "<e1>", "based", "on", "symptoms", "of", "pruritus", "and", "signs", "of", "C0700345#ent", "<e2>", "showed", "significant", "variation", "with", "the", "prevalence", "and", "quantity", "of", "yeast", "isolates", "."], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0700345", "name": "C0700345#ent", "pos": [13, 14]}}
{"token": ["In", "the", "C0027341#ent", "<e1>", "in", "Alport's", "syndrome", "variants", ",", "and", "in", "benign", "C0018965#ent", "<e2>", "the", "changes", "involve", "the", "glomerular", "basement", "membrane", "GBM", ")", "."], "h": {"id": "C0027341", "name": "C0027341#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0018965", "name": "C0018965#ent", "pos": [12, 13]}}
{"token": ["C0623362#ent", "<e1>", "MMPs", ")", "are", "related", "to", "tissue", "destruction", "remodeling", "events", "in", "C0031090#ent", "<e2>"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [12, 13]}}
{"token": ["C0623362#ent", "<e1>", "MMP", ")", "plays", "a", "crucial", "role", "in", "C0031090#ent", "<e2>", "is", "up-regulated", "by", "oral", "Gram-negative", ",", "pathogen-derived", "LPS", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [9, 10]}}
{"token": ["FMN", "reduction", "by", "C0376261#ent", "<e1>", "occurs", "as", "a", "single", "exponential", "process", "in", "the", "isolated", "C1416810#ent", "<e2>", "in", "contrast", "to", "the", "biphasic", "kinetics", "observed", "with", "native", "flavocytochrome", "b2"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416810", "name": "C1416810#ent", "pos": [14, 15]}}
{"token": ["All", "cells", "examined", "from", "the", "non-B", ",", "non-T", "acute", "lymphoblastic", "leukemia", "cell", "line", "C1706584#ent", "<e1>", ",", "stained", "positive", "both", "for", "terminal", "deoxynucleotidyl", "transferase", "for", "common", "C0812385#ent", "<e2>", "antigen", "."], "h": {"id": "C1706584", "name": "C1706584#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [25, 26]}}
{"token": ["Included", "in", "the", "review", "are", "a", "summary", "of", "C0991617#ent", "<e1>", "demonstrating", "success", "in", "preclinical", "investigations", "such", "as", ";", "farnesyl", "transferase", "inhibitors", "C0138843#ent", "<e2>", "dual", "inhibitors", "statins", ",", "bisphosphonates", ",", "histone", "deacetylase", "inhibitors", "other", "compounds", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0138843", "name": "C0138843#ent", "pos": [21, 22]}}
{"token": ["We", "have", "studied", "C1522428#ent", "<e1>", "(IL-1)-stimulated", "signals", "and", "gene", "expression", "mesangial", "cells", "C1417081#ent", "<e2>", ")", "to", "identify", "molecular", "mechanisms", "MC", "activation", ",", "a", "process", "characteristic", "of", "glomerular", "inflammation"], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417081", "name": "C1417081#ent", "pos": [12, 13]}}
{"token": ["For", "exploration", "on", "the", "elimination", "of", "C1413167#ent", "<e1>", "from", "the", "circulation", ",", "the", "disappearance", "half-time", "of", "C0039659#ent", "<e2>", "was", "estimated", "with", "cholecystokinin", "specific", "radioimmunoassay", "in", "normal", "subjects", "patients", "with", "chronic", "renal", "failure", "with", "hepatic", "cirrhosis"], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039659", "name": "C0039659#ent", "pos": [16, 17]}}
{"token": ["The", "four", "latter", "correspond", "to", "C1413167#ent", "<e1>", "CCK", "and", "its", "COOH-terminal", "dodeca-", ",", "octa-", "and", "C0039659#ent", "<e2>", "portions", ",", "respectively", "."], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039659", "name": "C0039659#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "therapeutic", "effects", "insulin-stimulated", "glucose", "disposal", "can", "be", "achieved", "in", "C0011860#ent", "<e1>", "subjects", "without", "altering", "C1420175#ent", "<e2>", "expression", "in", "muscle", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [16, 17]}}
{"token": ["Eighty", "nine", "patients", "with", "alveolitis", "[", "60", "with", "extrinsic", "allergic", "alveolitis", "C0242900#ent", "<e1>", ")", "and", "29", "with", "C1800706#ent", "<e2>", "IFA", ")", "]", "were", "followed", "up", "."], "h": {"id": "C0242900", "name": "C0242900#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1800706", "name": "C1800706#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "the", "impaired", "relaxation", "in", "C1420709#ent", "<e1>", "may", "result", "from", "a", "reduced", "C1415651#ent", "<e2>", "expression", "and/or", "a", "higher", "SR", "Ca(2+)", "."], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415651", "name": "C1415651#ent", "pos": [14, 15]}}
{"token": ["Structures", "of", "C3540564#ent", "<e1>", "ligand", "complexes", "offer", "insights", "into", "the", "design", "of", "novel", "C0003392#ent", "<e2>", "into", "the", "regulation", "of", "the", "catalytic", "activity", "RSKs", "."], "h": {"id": "C3540564", "name": "C3540564#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [13, 14]}}
{"token": ["Missense", "mutations", "C3811106#ent", "<e1>", "result", "in", "C1414056#ent", "<e2>", "a", "complex", "syndrome", "characterized", "by", "bone", "marrow", "failure", "telomerase", "enzyme", "deficiency", "and", "progressive", "telomere", "shortening"], "h": {"id": "C3811106", "name": "C3811106#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414056", "name": "C1414056#ent", "pos": [6, 7]}}
{"token": ["By", "extrapolation", ",", "our", "findings", "also", "support", "the", "assignment", "of", "pseudouridine", "synthase", "to", "certain", "physiologically", "important", "eukaryotic", "proteins", "contain", "Motif", "I", "including", "the", "human", "C3811106#ent", "<e1>", "alteration", "of", "which", "leads", "to", "the", "C1414056#ent", "<e2>"], "h": {"id": "C3811106", "name": "C3811106#ent", "pos": [24, 25]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414056", "name": "C1414056#ent", "pos": [32, 33]}}
{"token": ["Although", "C1424250#ent", "<e1>", "activates", "phospholipase", "C", "C1415793#ent", "<e2>", ")", "in", "other", "tissues", ",", "C1424250#ent", "<e1>", "coupling", "to", "C1415793#ent", "<e2>", "on", "either", "apical", "or", "basolateral", "surfaces", "of", "proximal", "tubule", "cells", "unclear", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [6, 7]}}
{"token": ["The", "C0002556#ent", "<e1>", "were", "derivatized", "with", "C0044226#ent", "<e2>", "to", "liquid", "chromatography", "a", "reversed-phase", "column", "and", "fluorescence", "detection"], "h": {"id": "C0002556", "name": "C0002556#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0044226", "name": "C0044226#ent", "pos": [6, 7]}}
{"token": ["Buffered", "lidocaine", "statistically", "less", "C0030193#ent", "<e1>", "than", "both", "C0023660#ent", "<e2>", "warmed", "lidocaine", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [8, 9]}}
{"token": ["Insulin-dependent", "phosphorylation", "of", "C0285558#ent", "<e1>", "not", "affected", "by", "C2350345#ent", "<e2>", "activation", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [8, 9]}}
{"token": ["Isolated", "neonatal", "cardiac", "myocytes", "infected", "with", "an", "adenovirus", "expressing", "constitutively", "active", "mutant", "forms", "of", "either", "C0285558#ent", "<e1>", "or", "Akt2", "also", "suppressed", "C2350345#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [21, 22]}}
{"token": ["C0285558#ent", "<e1>", "recombinant", "bacterially", "expressed", "C2350345#ent", "<e2>", "Ser(485", ")", "of", "the", "alpha1-subunits", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [5, 6]}}
{"token": ["In", "the", "yeast", "Saccharomyces", "cerevisiae", "mutations", "in", "either", "of", "two", "unlinked", "genes", ",", "RAM1", "or", "C1824685#ent", "<e1>", ",", "abolish", "the", "farnesyltransferase", "activity", "for", "prenylation", "of", "C0242853#ent", "<e2>", "the", "a-factor", "mating", "pheromone", "."], "h": {"id": "C1824685", "name": "C1824685#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [25, 26]}}
{"token": ["Extracts", "derived", "from", "an", "E.", "coli", "strain", "that", "coexpressed", "RAM1", "and", "C1824685#ent", "<e1>", "efficiently", "farnesylated", "a-factor", "peptide", "and", "C0242853#ent", "<e2>", "substrates", "."], "h": {"id": "C1824685", "name": "C1824685#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [18, 19]}}
{"token": ["CaCo-2", "cells", "incubated", "for", "18", "h", "with", "micelles", "containing", "5", "mM", "C2827312#ent", "<e1>", "and", "500", "microM", "C0028928#ent", "<e2>", "micelles", "containing", "either", "200", "microM", "cholesterol", "or", "150", "microM", "lysophosphatidylcholine", "."], "h": {"id": "C2827312", "name": "C2827312#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [16, 17]}}
{"token": ["C0004855#ent", "<e1>", "no", "effects", "on", "the", "C3539699#ent", "<e2>", "+", "current", "kinetics", "during", "a", "depolarizing", "test", "pulse", "."], "h": {"id": "C0004855", "name": "C0004855#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [6, 7]}}
{"token": ["CHIP", "(", "carboxyl", "terminus", "C1337104#ent", "<e1>", "is", "such", "a", "cofactor", "that", "interacts", "with", "C1415764#ent", "<e2>", "and", ",", "in", "general", ",", "attenuates", "its", "most", "well", "characterized", "functions", "."], "h": {"id": "C1337104", "name": "C1337104#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415764", "name": "C1415764#ent", "pos": [13, 14]}}
{"token": ["This", "study", "investigated", "the", "ability", "of", "proton", "pump", "inhibitors", "PPI", ")", ",", "such", "as", "omeprazole", "and", "C0795650#ent", "<e1>", ",", "to", "inhibit", "C1417739#ent", "<e2>", "calcium", "mobilization", "the", "mechanisms", "involved", "in", "this", "inhibition", "."], "h": {"id": "C0795650", "name": "C0795650#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417739", "name": "C1417739#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "the", "production", "of", "TGF-beta", "1", "the", "expression", "of", "TGF-beta", "1", "mRNA", "in", "C1334122#ent", "<e1>", "were", "greater", "than", "in", "C1367656#ent", "<e2>", "."], "h": {"id": "C1334122", "name": "C1334122#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1367656", "name": "C1367656#ent", "pos": [21, 22]}}
{"token": ["Efficacy", "(", "C0038358#ent", "<e1>", "rate", "among", "C0085174#ent", "<e2>", "treated", "patients", ")", "and", "compliance", "have", "a", "relatively", "low", "impact.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [2, 3]}, "relation": "may_be_prevented_by", "t": {"id": "C0085174", "name": "C0085174#ent", "pos": [6, 7]}}
{"token": ["Although", "gastric", "mucosal", "adaptation", "usually", "occurs", "with", "repeated", "therapeutic", "doses", "aspirin", ",", "some", "individuals", "nevertheless", "develop", "C0038358#ent", "<e1>", "simultaneous", "administration", "of", "the", "prostaglandin", "analogue", "C0085174#ent", "<e2>", "can", "reduce", "the", "risk", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [16, 17]}, "relation": "may_be_prevented_by", "t": {"id": "C0085174", "name": "C0085174#ent", "pos": [24, 25]}}
{"token": ["The", "aims", "of", "this", "study", "were", "to", "determine", "whether", "recombinant", "alpha-enolase", "(", "C1414402#ent", "<e1>", ")", ",", "encoded", "by", "ENO1", ",", "was", "a", "C2364020#ent", "<e2>", "to", "generate", "polyclonal", "antibodies", "this", "antigen", "."], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2364020", "name": "C2364020#ent", "pos": [22, 23]}}
{"token": ["Each", "growth", "factor", "in", "a", "different", "manner", "the", "association", "of", "C0089793#ent", "<e1>", "phosphotyrosine-containing", "proteins", "and", "with", "C1307053#ent", "<e2>", "thus", "probably", "modulates", "intracellular", "signals", "downstream", "of", "C0089793#ent", "<e1>", "astroglial", "cells"], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [10, 11]}}
{"token": ["Candidate", "C0031179#ent", "<e1>", "that", "remain", "include", "PGH", "synthases", "and", "uninduced", "C0597298#ent", "<e2>"], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [10, 11]}}
{"token": ["C0031179#ent", "<e1>", "isozyme", "studies", "indicated", "the", "presence", "of", "a", "unique", "basic", "C0597298#ent", "<e2>", "in", "stems", "after", "wounding", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}}
{"token": ["Yersinia", "pestis", "the", "causative", "agent", "the", "bubonic", ",", "C0243026#ent", "<e1>", ",", "and", "pneumonic", "plagues", "also", "known", "as", "C0152936#ent", "<e2>", "and", "has", "been", "responsible", "for", "recurrent", "devastating", "pandemics", "throughout", "history", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0152936", "name": "C0152936#ent", "pos": [17, 18]}}
{"token": ["The", "cytokine", ",", "TNF", "alpha", "the", "adhesion", "molecule", "C1706544#ent", "<e1>", "are", "important", "mediators", "in", "the", "pathogenesis", "of", "C3714497#ent", "<e2>", "as", "asthma", ",", "chronic", "bronchitis", "and", "adult", "respiratory", "distress", "syndrome"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714497", "name": "C3714497#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "activation", "of", "C1120843#ent", "<e1>", "TGF-beta", "was", "accelerated", "and", "enhanced", "in", "the", "absence", "of", "C1422519#ent", "<e2>", "."], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422519", "name": "C1422519#ent", "pos": [16, 17]}}
{"token": ["Seven", "additional", "years", "were", "subsequently", "devoted", "to", "research", "and", "manufacturing", "improvements", "in", "order", "to", "accomplish", "the", "recent", "licensing", "of", "a", "second", "C0795577#ent", "<e1>", "product", "(", "KOGENATE", "Bayer", "or", "C1815180#ent", "<e2>", "."], "h": {"id": "C0795577", "name": "C0795577#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1815180", "name": "C1815180#ent", "pos": [28, 29]}}
{"token": ["This", "activity", "is", "reduced", "or", "abolished", "by", "appropriate", "concentrations", "of", "C0000981#ent", "<e1>", "(", "or", "other", "C0038760#ent", "<e2>", "carbonic", "anhydrase", "and", "the", "powerful", "inorganic", "inhibitor", ",", "cyanate", "(", "CNO-", ")", "ion", "."], "h": {"id": "C0000981", "name": "C0000981#ent", "pos": [10, 11]}, "relation": "has_chemical_structure", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [15, 16]}}
{"token": ["We", "report", "the", "characterization", "of", "two", "C3541394#ent", "<e1>", "that", "catalyze", "NAD(+)-dependent", "9-cis-retinol", "dehydrogenase", "activity", "in", "rat", "C0267834#ent", "<e2>"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0267834", "name": "C0267834#ent", "pos": [16, 17]}}
{"token": ["The", "guanosine", "triphosphate", "GTP", ")", "cyclohydrolase", "I", "GTP-CHI", ")", "catalyses", "the", "rate-limiting", "step", "in", "the", "de", "novo", "synthesis", "of", "tetrahydrobiopterin", ",", "a", "cofactor", "of", "three", "C0301713#ent", "<e1>", "one", "of", "which", "is", "C1418251#ent", "<e2>"], "h": {"id": "C0301713", "name": "C0301713#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1418251", "name": "C1418251#ent", "pos": [31, 32]}}
{"token": ["The", "carriage", "of", "A", "C1706112#ent", "<e1>", "was", "significantly", "associated", "with", "C0035078#ent", "<e2>", "68.8", "vs.", "54.5", "%", ",", "OR", "1.84", ",", "95", "%", "CI", "1.07", "-", "3.18", ")", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [10, 11]}}
{"token": ["These", "data", "show", "that", "IFN-gamma", "can", "prime", "intestinal", "epithelial", "monolayers", "to", "respond", "to", "C0812246#ent", "<e1>", "by", "disrupting", "tight", "junction", "morphology", "and", "barrier", "function", "C2239763#ent", "<e2>", "up-regulation", "and", "MLC", "phosphorylation", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2239763", "name": "C2239763#ent", "pos": [23, 24]}}
{"token": ["C0812246#ent", "<e1>", "treatment", "of", "filter-grown", "Caco-2", "monolayers", "transfected", "with", "plasmid", "vector", "the", "C2239763#ent", "<e2>", "promoter", "region", "an", "increase", "in", "C2239763#ent", "<e2>", "promoter", "activity", "C2239763#ent", "<e2>", "transcription", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2239763", "name": "C2239763#ent", "pos": [12, 13]}}
{"token": ["For", "this", "reason", ",", "a", "mutation", "analysis", "the", "C1825633#ent", "<e1>", "a", "panel", "of", "50", "unrelated", "patients", "with", "C0035334#ent", "<e2>", "been", "performed", ",", "revealing", "no", "pathogenic", "mutations", "."], "h": {"id": "C1825633", "name": "C1825633#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [17, 18]}}
{"token": ["Newer", "C1268551#ent", "<e1>", ",", "such", "as", "C0532508#ent", "<e2>", "and", "the", "pneumocandins", ",", "have", "excellent", "activity", "against", "yeasts", "and", "Pneumocystis", "carinii", "infections", "in", "animals", "and", "show", "promise", "as", "potential", "clinical", "antifungal", "candidates", "."], "h": {"id": "C1268551", "name": "C1268551#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0532508", "name": "C0532508#ent", "pos": [6, 7]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "investigate", "the", "influence", "of", "the", "new", "C1268551#ent", "<e1>", "caspofungin", "(", "MK-0991", ")", "and", "anidulafungin", "(", "C0532508#ent", "<e2>", ")", "on", "human", "phagocytes", "."], "h": {"id": "C1268551", "name": "C1268551#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0532508", "name": "C0532508#ent", "pos": [23, 24]}}
{"token": ["To", "investigate", "the", "changes", "myocardial", "C3541394#ent", "<e1>", "related", "to", "glycolysis", "and", "fatty", "acid", "metabolism", "in", "C0010054#ent", "<e2>", "to", "evaluate", "the", "relationship", "between", "the", "gene", "expression", "glycolytic", "metabolism", "C3541394#ent", "<e1>", "and", "myocardial", "viability"], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}}
{"token": ["4-Hydroxy-2-nonenal", "(", "HNE", ")", ",", "a", "major", "product", "of", "lipid", "peroxidation", "increases", "in", "concentration", "upon", "reperfusion", "of", "C0010054#ent", "<e1>", "can", "react", "with", "and", "inactivate", "C3541394#ent", "<e2>", ",", "and", "inhibits", "mitochondrial", "respiration", "in", "vitro"], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [24, 25]}}
{"token": ["All", "the", "patients", "had", "a", "history", "of", "prolonged", "C0010054#ent", "<e1>", "electrocardiographic", "changes", "a", "rise", "in", "serum", "C3541394#ent", "<e2>", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["C0010054#ent", "<e1>", "interstitial", "leakage", "of", "cellular", "enzymes", "by", "release", "of", "these", "C3541394#ent", "<e2>", "into", "plasma", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "possible", "correlations", "between", "latent", "C0343641#ent", "<e1>", "CHPI", ")", "and", "other", "sexually", "transmitted", "diseases", "C0036916#ent", "<e2>", ")", "."], "h": {"id": "C0343641", "name": "C0343641#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [15, 16]}}
{"token": ["Human", "C0343641#ent", "<e1>", "probably", "the", "most", "prevalent", "C0036916#ent", "<e2>", "in", "the", "United", "States"], "h": {"id": "C0343641", "name": "C0343641#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [7, 8]}}
{"token": ["The", "authors", "want", "to", "report", "the", "case", "because", "it", "is", "an", "example", "of", "an", "association", "between", "lusoria", "dysphagia", "retroperitoneal", "fibrosis", "the", "connective", "tissue", "disease", "for", "C0154162#ent", "<e1>", "and", "perhaps", ",", "C1331537#ent", "<e2>"], "h": {"id": "C0154162", "name": "C0154162#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1331537", "name": "C1331537#ent", "pos": [30, 31]}}
{"token": ["Here", ",", "we", "show", "that", "V.", "cholerae", "controls", "the", "addition", "of", "a", "crossover", "at", "dif1", "and", "C1415884#ent", "<e1>", "by", "a", "common", "pair", "of", "C0034767#ent", "<e2>"], "h": {"id": "C1415884", "name": "C1415884#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034767", "name": "C0034767#ent", "pos": [23, 24]}}
{"token": ["C0078257#ent", "<e1>", "was", "found", "to", "bind", "to", "the", "membrane", "vesicles", "intensively", "than", "C0042679#ent", "<e2>", ",", "but", "the", "transport", "processes", "almost", "identical", "."], "h": {"id": "C0078257", "name": "C0078257#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [12, 13]}}
{"token": ["C0078257#ent", "<e1>", ",", "in", "comparison", "with", "C0042679#ent", "<e2>", "and", "VBL", ",", "is", "shown", "to", "have", "a", "lower", "inhibitory", "effect", "."], "h": {"id": "C0078257", "name": "C0078257#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [6, 7]}}
{"token": ["However", ",", "despite", "the", "close", "similarities", "of", "their", "structures", "the", "different", "vinca", "drugs", "very", "different", "release", "behavior", ",", "with", "vinblastine", "and", "C0078257#ent", "<e1>", "being", "released", "faster", "than", "C0042679#ent", "<e2>", "both", "in", "vitro", "in", "vivo"], "h": {"id": "C0078257", "name": "C0078257#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [27, 28]}}
{"token": ["To", "attempt", "to", "explain", "the", "cellular", "basis", "for", "the", "greater", "ODC-inducing", "ability", "of", "C0078956#ent", "<e1>", "relative", "to", "mezerein", "and", "C0162568#ent", "<e2>", "in", "chronic", "exposure", "protocols", ",", "immunocytochemical", "and", "flow", "cytometric", "analyses", "performed", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162568", "name": "C0162568#ent", "pos": [19, 20]}}
{"token": ["Compound", "1", "activity", "in", "the", "C0078956#ent", "<e1>", "and", "ethylphenylpropiolate", "(", "C0162568#ent", "<e2>", ")", "mouse", "ear", "edema", "the", "serotonin", "paw", "edema", "tests", ",", "whereas", "compound", "2", "active", "only", "in", "the", "mouse", "ear", "edema", "model"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162568", "name": "C0162568#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "C0700450#ent", "<e1>", "was", "attenuated", "by", "atenolol", ",", "and", "that", "of", "C0072032#ent", "<e2>", "by", "ICI", "118,551", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072032", "name": "C0072032#ent", "pos": [13, 14]}}
{"token": ["As", "compared", "with", "C0700450#ent", "<e1>", "and", "GS-332", ",", "isoproterenol", "and", "C0072032#ent", "<e2>", "significantly", "relaxed", "the", "detrusor", "strips", "derived", "from", "all", "groups", "on", "KCl-induced", "tonic", "contractions", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072032", "name": "C0072032#ent", "pos": [10, 11]}}
{"token": ["C0030305#ent", "<e1>", "induced", "in", "6", "cats", "by", "infusion", "of", "C0028928#ent", "<e2>", "the", "pancreatic", "duct"], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [9, 10]}}
{"token": ["Together", ",", "these", "findings", "show", "that", "lefty", "C0030956#ent", "<e1>", "are", "a", "new", "class", "of", "C3537035#ent", "<e2>", "restrain", "tumor", "growth"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537035", "name": "C3537035#ent", "pos": [14, 15]}}
{"token": ["The", "uptake", "of", "C0360097#ent", "<e1>", "by", "erythrocytes", "was", "decreased", "by", "C0008783#ent", "<e2>", "treatment.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [10, 11]}}
{"token": ["Each", "subject", "received", "separate", "oral", "(", "200", "mg", ")", "and", "intravenous", "(", "75", "or", "100", "mg", ")", "doses", "of", "C0360097#ent", "<e1>", "before", "and", "after", "C0008783#ent", "<e2>", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [24, 25]}}
{"token": ["The", "C0085387#ent", "<e1>", "indomethacin", "reduces", "proteinuria", "in", "patients", "with", "focal", "segmental", "glomerulosclerosis", "C0017668#ent", "<e2>", ")", "or", "other", "glomerular", "diseases"], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [12, 13]}}
{"token": ["The", "native", "C0015296#ent", "<e1>", "also", "had", "strong", "C0252912#ent", "<e2>", "similar", "to", "that", "observed", "with", "RTH1", "nuclease", "homologous", "yeast", "RAD2", ")", "and", "mammalian", "enzymes", "."], "h": {"id": "C0015296", "name": "C0015296#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0252912", "name": "C0252912#ent", "pos": [7, 8]}}
{"token": ["The", "native", "C0015296#ent", "<e1>", "also", "had", "strong", "flap", "endonuclease", "similar", "to", "that", "observed", "with", "C0252912#ent", "<e2>", "homologous", "yeast", "RAD2", ")", "and", "mammalian", "enzymes", "."], "h": {"id": "C0015296", "name": "C0015296#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0252912", "name": "C0252912#ent", "pos": [14, 15]}}
{"token": ["The", "5", "'", "--", ">", "3", "'", "C0015296#ent", "<e1>", "DNA", "polymerase", "I", "a", "homolog", "of", "the", "mammalian", "C0252912#ent", "<e2>", "and", "the", "yeast", "RAD27", "flap", "nucleases", "."], "h": {"id": "C0015296", "name": "C0015296#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0252912", "name": "C0252912#ent", "pos": [17, 18]}}
{"token": ["We", "have", "investigated", "lipid", "peroxidation", "oxidation", "of", "lignoceric", "acid", "response", "to", "oral", "C0039943#ent", "<e1>", "administration", ",", "to", "better", "understand", "the", "effects", "of", "C0031436#ent", "<e2>", ",", "which", "are", "one", "of", "the", "more", "commonly", "used", "therapeutic", "agents"], "h": {"id": "C0039943", "name": "C0039943#ent", "pos": [12, 13]}, "relation": "has_chemical_structure", "t": {"id": "C0031436", "name": "C0031436#ent", "pos": [22, 23]}}
{"token": ["C0039943#ent", "<e1>", "is", "a", "member", "of", "the", "class", "of", "C0031436#ent", "<e2>", "that", "act", ",", "in", "part", ",", "by", "inhibiting", "respiration", "."], "h": {"id": "C0039943", "name": "C0039943#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0031436", "name": "C0031436#ent", "pos": [9, 10]}}
{"token": ["The", "results", "obtained", "are", "compared", "with", "our", "previous", "findings", "of", "analogous", "experiments", "concerning", "C0039943#ent", "<e1>", ",", "and", "with", "the", "data", "on", "other", "C0031436#ent", "<e2>", "and", "species", "."], "h": {"id": "C0039943", "name": "C0039943#ent", "pos": [13, 14]}, "relation": "has_chemical_structure", "t": {"id": "C0031436", "name": "C0031436#ent", "pos": [22, 23]}}
{"token": ["In", "those", "cells", ",", "C0006938#ent", "<e1>", "also", "reduces", "estrogen", "receptor", "ER", ")", "and", "increases", "C1366500#ent", "<e2>", "PR", ")", "concentrations", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366500", "name": "C1366500#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "the", "levels", "of", "ASN2", "and", "C1442750#ent", "<e1>", "mRNA", "are", "also", "reciprocally", "regulated", "by", "C0524928#ent", "<e2>", "and", "nitrogen", "metabolites"], "h": {"id": "C1442750", "name": "C1442750#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [15, 16]}}
{"token": ["The", "effect", "of", "riboflavin", "supplementation", "(", "5", "mg", "twice", "daily", "for", "8", "weeks", ")", "on", "reduced", "blood", "glutathione", "C1260386#ent", "<e1>", ")", "and", "iron", "status", "assessed", "in", "18", "patients", "with", "C0002895#ent", "<e2>", "SCD-HbSS", ")", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [29, 30]}}
{"token": ["Adrenomedullin", "(", "C1412244#ent", "<e1>", ")", ",", "encoded", "by", "the", "C0215825#ent", "<e2>", "(", "ppADM", ")", "gene", ",", "exerts", "multiple", "effects", "in", "a", "wide", "variety", "of", "peripheral", "and", "central", "tissues"], "h": {"id": "C1412244", "name": "C1412244#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0215825", "name": "C0215825#ent", "pos": [9, 10]}}
{"token": ["These", "compounds", "used", "so", "far", "mostly", "as", "hepatoprotectants", "were", "shown", "to", "have", "other", "interesting", "activities", ",", "e.g.", "C0003392#ent", "<e1>", "and", "canceroprotective", "and", "also", "C0151718#ent", "<e2>"], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0151718", "name": "C0151718#ent", "pos": [23, 24]}}
{"token": ["Co-receptors", "are", "essential", "for", "LRP-mediated", "clearance", "of", "several", "ligands", "(", "e.g.", "C3536869#ent", "<e1>", "for", "thrombin/protease", "nexin", "and", "C1416902#ent", "<e2>", "and", "the", "urokinase", "receptor", "urokinase/PAI-1", "complexes", ")", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [17, 18]}}
{"token": ["Adenosine", "has", "been", "used", "as", "an", "adjunct", "to", "both", "C0056562#ent", "<e1>", "and", "blood", "cardioplegia", "but", "its", "potential", "as", "a", "C0007209#ent", "<e2>", "not", "been", "fully", "explored", "."], "h": {"id": "C0056562", "name": "C0056562#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [19, 20]}}
{"token": ["To", "investigate", "the", "hemodynamics", "of", "ophthalmic", "artery", "OA", ")", "and", "central", "retinal", "artery", "C1836205#ent", "<e1>", ")", "in", "patients", "with", "C0339573#ent", "<e2>", "and", "analyse", "the", "correlation", "between", "hemodynamics", "of", "OA", "and", "C1836205#ent", "<e1>", "and", "other", "factors", "."], "h": {"id": "C0339573", "name": "C0339573#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1836205", "name": "C1836205#ent", "pos": [13, 14]}}
{"token": ["It", "was", "observed", "that", "total", "expression", "of", "RNA", "polymerase", "activity", "was", "only", "marginally", "inhibited", "because", ",", "while", "expression", "of", "C0035679#ent", "<e1>", "III", "showed", "remarkable", "inhibition", ",", "C0035681#ent", "<e2>", "stimulation", "in", "activity", "."], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [19, 20]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [26, 27]}}
{"token": ["In", "AH-130", "cells", "the", "activity", "of", "C0035681#ent", "<e1>", "4", "to", "5", "times", "higher", "than", "C0035679#ent", "<e2>", "and", "in", "rat", "liver", "the", "activity", "of", "C0035681#ent", "<e1>", "1.5", "to", "2", "times", "higher", "than", "C0035679#ent", "<e2>"], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [6, 7]}}
{"token": ["RNAs", "bound", "by", "the", "La", "protein", "all", "nascent", "transcripts", "made", "by", "C0035679#ent", "<e1>", "well", "as", "certain", "small", "RNAs", "synthesized", "by", "other", "C0035681#ent", "<e2>"], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [21, 22]}}
{"token": ["Novel", "microemulsion", "formulations", "containing", "all", "chiral", "components", "described", "for", "the", "enantioseparation", "of", "six", "pairs", "of", "pharmaceutical", "enantiomers", "atenolol", ",", "C0014479#ent", "<e1>", ",", "metoprolol", ",", "N-methyl", "ephedrine", "pseudoephedrine", ",", "and", "C0039086#ent", "<e2>", ")", "."], "h": {"id": "C0014479", "name": "C0014479#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0039086", "name": "C0039086#ent", "pos": [29, 30]}}
{"token": ["Novel", "microemulsion", "formulations", "containing", "all", "chiral", "components", "described", "for", "the", "enantioseparation", "of", "six", "pairs", "of", "pharmaceutical", "enantiomers", "atenolol", ",", "ephedrine", ",", "metoprolol", ",", "C0014479#ent", "<e1>", "pseudoephedrine", ",", "and", "C0039086#ent", "<e2>", ")", "."], "h": {"id": "C0014479", "name": "C0014479#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0039086", "name": "C0039086#ent", "pos": [28, 29]}}
{"token": ["administration", ",", "C0045376#ent", "<e1>", "was", "as", "effective", "as", "C0031381#ent", "<e2>", "and", "diazepam", "in", "protecting", "against", "audiogenic", "seizures", "had", "a", "therapeutic", "ratio", "higher", "than", "diazepam", "'s", "and", "7-fold", "higher", "than", "PCP", "'s", "."], "h": {"id": "C0045376", "name": "C0045376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [8, 9]}}
{"token": ["Nimesulide", ",", "meclofenamate", ",", "and", "piroxicam", "were", "more", "selective", "towards", "SULT1A1", "inhibition", ",", "while", "sulindac", "and", "C0020740#ent", "<e1>", "were", "more", "selective", "towards", "C0059669#ent", "<e2>", "inhibition", "."], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0059669", "name": "C0059669#ent", "pos": [22, 23]}}
{"token": ["Minimal", "change", "C0027726#ent", "<e1>", ",", "the", "main", "pediatric", "form", "of", "C3496337#ent", "<e2>", "usually", "a", "benign", "condition", "responsive", "to", "standard", "steroid", "treatment", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C3496337", "name": "C3496337#ent", "pos": [10, 11]}}
{"token": ["The", "C0544482#ent", "<e1>", "encoded", "by", "two", "duplicated", "genes", "C1415478#ent", "<e2>", "and", "HBA1", ",", "5'-3", "'", ")", "showing", "overall", "sequence", "homology", ">", "96", "%", "and", "average", "CG", "content", ">", "60", "%", "."], "h": {"id": "C0544482", "name": "C0544482#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415478", "name": "C1415478#ent", "pos": [8, 9]}}
{"token": ["In", "this", "study", "Sch", "39304", "favorably", "with", "amphotericin", "B", "treating", "C0019655#ent", "<e1>", "in", "normal", "and", "leukopenic", "mice", "whereas", "C0016277#ent", "<e2>", "was", "much", "less", "active", "."], "h": {"id": "C0019655", "name": "C0019655#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [18, 19]}}
{"token": ["There", "was", "no", "significant", "correlation", "between", "the", "levels", "of", "C1515370#ent", "<e1>", "or", "sFas", "and", "clinical", "variables", "C0024117#ent", "<e2>", "patients", "."], "h": {"id": "C1515370", "name": "C1515370#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [16, 17]}}
{"token": ["The", "purpose", "of", "this", "study", "is", "to", "assess", "the", "potential", "role", "of", "the", "C1515370#ent", "<e1>", "FasL", ")", "system", "in", "cachexic", "patients", "with", "C0024117#ent", "<e2>", "."], "h": {"id": "C1515370", "name": "C1515370#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [22, 23]}}
{"token": ["In", "these", "cases", ",", "the", "expression", "of", "PKHD1", "(", "polycystic", "kidney", "hepatic", "disease", "1", "and", "UMOD", "(", "C0077918#ent", "<e1>", ")", ",", "two", "genes", "regulated", "by", "C2348633#ent", "<e2>", ",", "was", "turned", "off", "."], "h": {"id": "C0077918", "name": "C0077918#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2348633", "name": "C2348633#ent", "pos": [25, 26]}}
{"token": ["The", "discovery", "of", "C0077918#ent", "<e1>", "mutations", "as", "a", "cause", "of", "C2348633#ent", "<e2>", "and", "MCKD2", "raises", "a", "new", "question", ";", "Why", "the", "mutant", "C0077918#ent", "<e1>", "causes", "uricemic", "underexcretion", "and", "hyperuricemia", "?"], "h": {"id": "C0077918", "name": "C0077918#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2348633", "name": "C2348633#ent", "pos": [10, 11]}}
{"token": ["Mutations", "of", "the", "UMOD", "gene", ",", "disrupting", "the", "tertiary", "structure", "C0077918#ent", "<e1>", ",", "cause", "MCKD2", "and", "C2348633#ent", "<e2>", "."], "h": {"id": "C0077918", "name": "C0077918#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2348633", "name": "C2348633#ent", "pos": [16, 17]}}
{"token": ["Thrombomodulin", "(", "TM", ")", "is", "a", "newly", "described", "endothelial", "cell", "protein", "that", "functions", "as", "a", "potent", "natural", "C0003280#ent", "<e1>", "by", "converting", "C1414504#ent", "<e2>", "from", "a", "procoagulant", "protease", "to", "an", "C0003280#ent", "<e1>", "."], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [17, 18]}}
{"token": ["Thrombomodulin", "(", "TM", ")", "is", "an", "endothelial", "cell", "thrombin", "receptor", "converts", "C1414504#ent", "<e1>", "from", "a", "procoagulant", "to", "an", "C0003280#ent", "<e2>"], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [18, 19]}}
{"token": ["Thrombomodulin", "is", "a", "surface", "protein", "vascular", "endothelial", "cells", "serves", "as", "a", "binding", "site", "C1414504#ent", "<e1>", "and", "plays", "an", "important", "role", "as", "an", "C0003280#ent", "<e2>"], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [22, 23]}}
{"token": ["C1823503#ent", "<e1>", "neurones", "changed", "firing", "pattern", "over", "time", ",", "from", "C3543842#ent", "<e2>", "to", "burst", "in", "a", "time", "interval", "several", "seconds", "to", "tens", "of", "seconds", "."], "h": {"id": "C1823503", "name": "C1823503#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [10, 11]}}
{"token": ["Multiple", "C0678933#ent", "<e1>", "ethnic-specific", "factors", "are", "likely", "involved", "in", "the", "human", "immune", "response", "C0041296#ent", "<e2>", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [13, 14]}}
{"token": ["All", "children", "had", "marked", "increases", "in", "serum", "IgG", "intravenous", "gamma", "globulin", "except", "one", "who", "had", "undergone", "splenectomy", "and", "who", "had", "C0272293#ent", "<e1>", "high", "baseline", "levels", "of", "C3536873#ent", "<e2>", "IgG", ")", "."], "h": {"id": "C0272293", "name": "C0272293#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3536873", "name": "C3536873#ent", "pos": [26, 27]}}
{"token": ["Gastrin-releasing", "peptide", "1", "-", "27", ")", "and", "C1333714#ent", "<e1>", "18", "-", "27", ")", "(", "C3714923#ent", "<e2>", "were", "isolated", "from", "the", "tumor", "but", "C1333714#ent", "<e1>", "14", "-", "27", ")", "and", "bombesin", "were", "absent", "."], "h": {"id": "C3714923", "name": "C3714923#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [7, 8]}}
{"token": ["C0015523#ent", "<e1>", "characterised", "by", "a", "C0019069#ent", "<e2>", "factor", "XI", "the", "absence", "of", "factor", "XI-related", "antigen", "circulation", "."], "h": {"id": "C0015523", "name": "C0015523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [5, 6]}}
{"token": ["To", "investigate", "the", "potential", "influence", "of", "a", "C0015523#ent", "<e1>", "on", "the", "clinical", "phenotype", "mild/moderate", "haemophilia", "A", "28", "unrelated", "C0019069#ent", "<e2>", "of", "Jewish", "origin", "were", "screened", "for", "the", "two", "most", "common", "factor", "XI", "gene", "mutations"], "h": {"id": "C0015523", "name": "C0015523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [18, 19]}}
{"token": ["Diagnostic", "criteria", "the", "identification", "of", "the", "residual", "pancreas", "signs", "of", "C0152014#ent", "<e1>", "radiological", "signs", "of", "C0149521#ent", "<e2>"], "h": {"id": "C0152014", "name": "C0152014#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [15, 16]}}
{"token": ["We", "genotyped", "202", "C0002170#ent", "<e1>", "patients", "and", "175", "matched", "Caucasian", "controls", "the", "C1412304#ent", "<e2>", "G961C", "alleles", "."], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412304", "name": "C1412304#ent", "pos": [12, 13]}}
{"token": ["We", "have", "previously", "detected", "an", "association", "between", "C0002170#ent", "<e1>", "single", "nucleotide", "polymorphisms", "SNPs", ")", "in", "the", "C1412304#ent", "<e2>"], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412304", "name": "C1412304#ent", "pos": [16, 17]}}
{"token": ["Transcription", "factor", "Ets", "variant", "gene", "5", "C1414477#ent", "<e1>", ")", "participates", "in", "tumor", "metastasis", "and", "matrix", "metalloproteinase-7", "C0166059#ent", "<e2>", ")", "also", "plays", "an", "important", "role", "in", "tumor", "invasion", "metastasis", "."], "h": {"id": "C1414477", "name": "C1414477#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0166059", "name": "C0166059#ent", "pos": [16, 17]}}
{"token": ["C1413399#ent", "<e1>", "is", "the", "most", "strongly", "activated", "of", "those", "C1417679#ent", "<e2>", "that", "are", "up-regulated", "by", "DeltaBMPR", "and", "is", "the", "gene", "most", "strongly", "inhibited", "by", "Vox", "expression"], "h": {"id": "C1413399", "name": "C1413399#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}}
{"token": ["The", "clinical", "manifestations", "hypotonia", ",", "C0004158#ent", "<e1>", ",", "sensory", "neuropathy", "ataxia", ",", "hearing", "deficit", "ophthalmoplegia", ",", "intractable", "C0014544#ent", "<e2>", "and", "elevation", "of", "serum", "transaminases"], "h": {"id": "C0004158", "name": "C0004158#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [17, 18]}}
{"token": ["Epithelial", "Langerhans", "'", "cells", "(", "C1423693#ent", "<e1>", ")", "represent", "a", "possible", "source", "of", "initial", "cell", "contact", "C0404521#ent", "<e2>"], "h": {"id": "C1423693", "name": "C1423693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0404521", "name": "C0404521#ent", "pos": [16, 17]}}
{"token": ["We", "examined", "the", "effects", "of", "C0304516#ent", "<e1>", "exercise-induced", "regional", "ischemia", "in", "10", "conscious", "dogs", "with", "C0948480#ent", "<e2>"], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0948480", "name": "C0948480#ent", "pos": [15, 16]}}
{"token": ["Treatment", "with", "any", "of", "the", "aforementioned", "C0991617#ent", "<e1>", "is", "not", "accompanied", "by", "quantitative", "changes", "in", "the", "C1334076#ent", "<e2>", "surface", "expression", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334076", "name": "C1334076#ent", "pos": [16, 17]}}
{"token": ["For", "instance", ",", "a", "point", "mutation", "in", "a", "human", "clock", "gene", "Per2", ")", "was", "shown", "to", "produce", "the", "rare", "C0751758#ent", "<e1>", "whereas", "a", "functional", "polymorphism", "in", "C0812265#ent", "<e2>", "is", "associated", "with", "more", "frequent", "delayed", "sleep", "phase", "syndrome"], "h": {"id": "C0751758", "name": "C0751758#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0812265", "name": "C0812265#ent", "pos": [26, 27]}}
{"token": ["These", "results", "indicate", "that", "C0771988#ent", "<e1>", "may", "have", "therapeutical", "potential", "an", "anti-craving", "drug", "for", "C0001975#ent", "<e2>", "."], "h": {"id": "C0771988", "name": "C0771988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [14, 15]}}
{"token": ["Hirschsprung's", "Disease", "HD", ")", "or", "congenital", "intestinal", "aganglionosis", "a", "major", "developmental", "anomaly", "intestine", ",", "which", "causes", "functional", "C0021843#ent", "<e1>", "is", "frequently", "associated", "with", "C0010346#ent", "<e2>", "."], "h": {"id": "C0021843", "name": "C0021843#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [23, 24]}}
{"token": ["This", "study", "was", "undertaken", "to", "investigate", "the", "neuromuscular", "blocking", "profile", "cardiovascular", "effects", "Org", "9487", "a", "new", "aminosteroidal", ",", "C0027867#ent", "<e1>", ",", "neuromuscular", "blocking", "agent", "related", "to", "C0042435#ent", "<e2>", ",", "in", "anaesthetized", "animals", "and", "in", "isolated", "muscle", "preparations", "."], "h": {"id": "C0027867", "name": "C0027867#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [26, 27]}}
{"token": ["These", "results", "indicate", "that", "whereas", "glucocorticoid", "action", "is", "localized", "in", "C1424810#ent", "<e1>", ",", "DCT", ",", "CCT", "and", "C0724624#ent", "<e2>", ",", "the", "mineralocorticoid", "effect", "restricted", "to", "the", "CCT", "and", "C0724624#ent", "<e2>", "exclusively", "."], "h": {"id": "C1424810", "name": "C1424810#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [17, 18]}}
{"token": ["Cyclic", "AMP", "metabolism", "was", "analyzed", "in", "microdissected", "C1424810#ent", "<e1>", "and", "in", "medullary", "collecting", "tubule", "C0724624#ent", "<e2>", ")", "."], "h": {"id": "C1424810", "name": "C1424810#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "in", "the", "hairy", "cell", "line", "EH", "inhibition", "of", "Ras", "signaling", "C0169101#ent", "<e1>", "2", "(", "MEK1/2", ")", "reduced", "not", "only", "C1334145#ent", "<e2>", "promoter", "activity", "also", "reduced", "both", "C1334145#ent", "<e2>", "surface", "expression", "and", "proliferation", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334145", "name": "C1334145#ent", "pos": [21, 22]}}
{"token": ["The", "roles", "of", "radionuclide", "liver", "scanning", "ultrasound", "and", "CT", "in", "C0023895#ent", "<e1>", "discussed", "and", "characteristic", "CT", "findings", "of", "C2931187#ent", "<e2>", "trauma", ",", "abscess", ",", "primary", "and", "metastatic", "malignancy", "fatty", "infiltration", "hemochromatosis", ",", "and", "obstructive", "jaundice", "illustrated", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2931187", "name": "C2931187#ent", "pos": [18, 19]}}
{"token": ["However", ",", "significant", "C0023895#ent", "<e1>", "portal", "hypertension", "not", "a", "common", "complication", "of", "C2931187#ent", "<e2>", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2931187", "name": "C2931187#ent", "pos": [12, 13]}}
{"token": ["The", "capacity", "for", "intralysosomal", "proteolysis", ",", "as", "shown", "by", "sensitivity", "to", "methylamine", "or", "C0033607#ent", "<e1>", "fell", "55", "-", "75", "%", "in", "muscles", "from", "C1335499#ent", "<e2>", "rats", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335499", "name": "C1335499#ent", "pos": [23, 24]}}
{"token": ["Unexpectedly", ",", "we", "found", "mouse", "220-kD", "protein", "to", "be", "highly", "C1512488#ent", "<e1>", "to", "rat", "protein", "C1420744#ent", "<e2>", ",", "only", "a", "part", "of", "which", "had", "been", "already", "sequenced", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420744", "name": "C1420744#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "the", "highly", "C1512488#ent", "<e1>", "alpha-actinin", "family", "member", "alpha-actinin-1", ",", "displayed", "no", "association", "with", "C1420744#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420744", "name": "C1420744#ent", "pos": [16, 17]}}
{"token": ["This", "sequence", "is", "92", "and", "87", "%", "C1512488#ent", "<e1>", "to", "human", "and", "mouse", "C1420744#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420744", "name": "C1420744#ent", "pos": [13, 14]}}
{"token": ["Polymerase", "chain", "reaction", "PCR", ")", "amplification", "of", "DNA", "was", "used", "to", "detect", "the", "etiologic", "agent", "C0041471#ent", "<e1>", "Rickettsia", "typhi", "in", "experimentally", "infected", "adult", "C0277355#ent", "<e2>", "."], "h": {"id": "C0041471", "name": "C0041471#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0277355", "name": "C0277355#ent", "pos": [23, 24]}}
{"token": ["[3H]Corticosterone", "also", "bound", "to", "presumed", "C1452313#ent", "<e1>", "in", "plasma", "with", "high", "affinity", "C1705240#ent", "<e2>", "approximately", "2.7", "nM", ")", ",", "but", "dexamethasone", "and", "androgens", "bound", "to", "plasma", "C1452313#ent", "<e1>", "with", "equivalently", "high", "affinity", "."], "h": {"id": "C1452313", "name": "C1452313#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [12, 13]}}
{"token": ["The", "pre-", "and", "postoperative", "Bmax", "values", "of", "C1452313#ent", "<e1>", "were", "41", "and", "79", ",", "and", "C1705240#ent", "<e2>", "values", "were", "3.8", "and", "5.5", "."], "h": {"id": "C1452313", "name": "C1452313#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [15, 16]}}
{"token": ["Our", "data", "suggest", "that", "15d-PGJ(2", ")", "and", "rosiglitazone", "suppress", "the", "initiation", "of", "JAK-STAT", "inflammatory", "signaling", "independently", "of", "C1418779#ent", "<e1>", ",", "thus", "attenuating", "C0014070#ent", "<e2>"], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014070", "name": "C0014070#ent", "pos": [22, 23]}}
{"token": ["C2001156#ent", "<e1>", "suPAR", "also", "induced", "activation", "of", "C0084219#ent", "<e2>", "in", "THP-1", "cells", ",", "with", "a", "time", "course", "with", "ATF", "."], "h": {"id": "C2001156", "name": "C2001156#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0084219", "name": "C0084219#ent", "pos": [7, 8]}}
{"token": ["The", "histories", "were", "chronic", "and", "complex", "suggesting", "an", "C0004364#ent", "<e1>", "prolonged", "recurrent", "fever", "despite", "antibiotic", "therapy", "a", "C3890737#ent", "<e2>", "blood", "cultures", "negative", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C3890737", "name": "C3890737#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "the", "blocking", "of", "intracellular", "C0812281#ent", "<e1>", "by", "a", "cell-permeant", "antioxidant", "diminished", "completely", "the", "induction", "of", "C0051427#ent", "<e2>", "and", "apoptosis", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0051427", "name": "C0051427#ent", "pos": [18, 19]}}
{"token": ["Cystic", "fibrosis", "CF", ")", "is", "a", "C0019247#ent", "<e1>", "by", "abnormal", "regulation", "of", "C0384156#ent", "<e2>"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0384156", "name": "C0384156#ent", "pos": [12, 13]}}
{"token": ["The", "voltage-", "and", "rate-dependence", "of", "the", "depression", "of", "the", "maximum", "rate", "C0033036#ent", "<e1>", "(", "Vmax", ")", "by", "therapeutic", "concentrations", "flecainide", "and", "C0065183#ent", "<e2>", "were", "studied", "in", "guinea-pig", "ventricle", "standard", "microelectrode", "techniques", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0065183", "name": "C0065183#ent", "pos": [21, 22]}}
{"token": ["SnRK3s", "(", "Group", "3", "of", "the", "SNF-1", "related", "C0031727#ent", "<e1>", ")", "bind", "to", "proteins", "that", "contain", "three", "C0059036#ent", "<e2>", "hands", ",", "and", "some", "are", "activated", "by", "calcium", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [17, 18]}}
{"token": ["The", "Saccharomyces", "cerevisiae", "rad6", "C1434353#ent", "<e1>", ",", "and", "rad52", "mutants", "exhibit", "C1333237#ent", "<e2>", "deficiencies", "and", "distinct", "mutator", "phenotypes", "."], "h": {"id": "C1434353", "name": "C1434353#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [11, 12]}}
{"token": ["We", "assessed", "the", "effects", "of", "salt", "(", "AGs", ")", "ingestion", "on", "C0004099#ent", "<e1>", "hormonal", "alterations", "in", "highly", "trained", "(", "age", "18", "-", "22", "C1337037#ent", "<e2>", ")", "."], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1337037", "name": "C1337037#ent", "pos": [23, 24]}}
{"token": ["Cells", "containing", "resistance-conferring", "mutations", "in", "C1458146#ent", "<e1>", "also", "resistant", "to", "C1455513#ent", "<e2>", "."], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [5, 6]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C1455513", "name": "C1455513#ent", "pos": [10, 11]}}
{"token": ["This", "study", "investigated", "the", "prevalence", "of", "mothers", "'", "anxiety", ",", "depression", ",", "and", "posttraumatic", "stress", "disorder", "PTSD", ")", "symptoms", "triggered", "by", "their", "C0011854#ent", "<e1>", "identified", "individual", "C0342257#ent", "<e2>", "traumatic", "stressors"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C0342257", "name": "C0342257#ent", "pos": [26, 27]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "cochlear", "micromechanics", "in", "C0011854#ent", "<e1>", "patients", "and", "to", "compare", "these", "findings", "with", "C0342257#ent", "<e2>", "retinopathy", "and", "nephropathy", ")", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0342257", "name": "C0342257#ent", "pos": [21, 22]}}
{"token": ["The", "neurocontroller", "design", "uses", "a", "powerful", "technique", "of", "the", "adaptive", "critic", "design", "C1275685#ent", "<e1>", ")", "family", "called", "dual", "heuristic", "programming", "(", "C0220821#ent", "<e2>", ")", "."], "h": {"id": "C1275685", "name": "C1275685#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0220821", "name": "C0220821#ent", "pos": [21, 22]}}
{"token": ["Our", "data", "demonstrate", "that", "TAT", "changes", "the", "properties", "of", "C1417772#ent", "<e1>", "in", "vivo", "that", "long-term", "intracellular", "delivery", "of", "C1417772#ent", "<e1>", "by", "TAT", "corrects", "C0268125#ent", "<e1>", "mice", "."], "h": {"id": "C1417772", "name": "C1417772#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0268125", "name": "C0268125#ent", "pos": [23, 24]}}
{"token": ["Elevated", "serum", "transaminases", "particularly", "SGOT", ",", "as", "a", "result", "of", "acetylsalicylic", "acid", "C0007804#ent", "<e1>", ")", "therapy", "have", "been", "reported", "in", "patients", "with", "juvenile", "rheumatoid", "arthritis", "C3714757#ent", "<e2>", ")", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [25, 26]}}
{"token": ["Elevated", "serum", "transaminases", "particularly", "SGOT", ",", "as", "a", "result", "of", "acetylsalicylic", "acid", "C0007804#ent", "<e1>", ")", "therapy", "have", "been", "reported", "in", "patients", "with", "C3714757#ent", "<e2>", "JRA", ")", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [22, 23]}}
{"token": ["C0030794#ent", "<e1>", "defined", "as", "lower", "C0000737#ent", "<e2>", "is", "associated", "with", "the", "menstrual", "cycle", "sexual", "activity"], "h": {"id": "C0030794", "name": "C0030794#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [5, 6]}}
{"token": ["No", "standard", "screening", "instrument", "available", "enabling", "physicians", "to", "assign", "the", "diagnosis", "C0030794#ent", "<e1>", "CPP", ")", "to", "women", "with", "lower", "C0000737#ent", "<e2>"], "h": {"id": "C0030794", "name": "C0030794#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [19, 20]}}
{"token": ["A", "24-year-old", "woman", "with", "a", "history", "of", "C0030794#ent", "<e1>", "5", "years", "presented", "with", "C0000737#ent", "<e2>"], "h": {"id": "C0030794", "name": "C0030794#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [13, 14]}}
{"token": ["A", "74-year-old", "woman", "with", "chronic", "auricular", "fibrillation", "arterial", "hypertension", "hypercholesterolemia", ",", "C0238309#ent", "<e1>", "and", "peripheral", "arteriopathy", "with", "C0034150#ent", "<e2>", "the", "lower", "limbs", "Fig.", "1", ")", "and", ",", "to", "a", "lesser", "extent", "on", "the", "anterior", "area", "the", "chest", "."], "h": {"id": "C0238309", "name": "C0238309#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0034150", "name": "C0034150#ent", "pos": [17, 18]}}
{"token": ["Verapamil", ",", "0.03", "-", "0.3", "mg/Kg", ",", "also", "increased", "C0235480#ent", "<e1>", ",", "VR", ",", "and", "C0079423#ent", "<e2>", "to", "the", "lesser", "extent", "than", "perhexiline", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079423", "name": "C0079423#ent", "pos": [15, 16]}}
{"token": ["The", "22Na", "uptake", "due", "to", "C0006945#ent", "<e1>", "was", "inhibited", "by", "atropine", ",", "C0033216#ent", "<e2>", "or", "CoCl2", ";", "the", "response", "to", "Substance", "P", "inhibited", "by", "CoCl2", "only", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [12, 13]}}
{"token": ["C1336677#ent", "<e1>", "associated", "with", "HAT", "Tip60", "and", "PCAF", "at", "the", "Mad1", "and", "C1708842#ent", "<e2>", "promoters", "in", "a", "cell", "cycle-dependent", "manner", "and", "C1336677#ent", "<e1>", "depletion", "abolished", "recruitment", "of", "these", "HATs", "."], "h": {"id": "C1708842", "name": "C1708842#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1336677", "name": "C1336677#ent", "pos": [0, 1]}}
{"token": ["In", "conclusion", ",", "our", "study", "showed", "that", "inhibition", "of", "C0003692#ent", "<e1>", "by", "MK886", "could", "augment", "the", "antitumor", "activity", "C0538927#ent", "<e2>", "in", "human", "colorectal", "cancer"], "h": {"id": "C0003692", "name": "C0003692#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [18, 19]}}
{"token": ["The", "class", "I", "C0030956#ent", "<e1>", "bound", "with", "the", "same", "strength", "by", "the", "C1419895#ent", "<e2>", "PDZ2", "domain", ",", "though", "the", "electrostatic", "interaction", "energy", "of", "the", "P-2", "residue", "smaller", "for", "class", "I", "peptides", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419895", "name": "C1419895#ent", "pos": [12, 13]}}
{"token": ["The", "incidence", "of", "abnormal", "ECG", "findings", "in", "this", "group", "of", "children", "with", "either", "probable", "or", "definite", "C1539521#ent", "<e1>", "was", "thus", "29", "%", ",", "with", "1", "degree", "C0151517#ent", "<e2>", "most", "frequently", "."], "h": {"id": "C1539521", "name": "C1539521#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0151517", "name": "C0151517#ent", "pos": [26, 27]}}
{"token": ["Experimental", "studies", "pregnant", "rabbits", "C0722799#ent", "<e1>", "in", "both", "low", "and", "high", "dosage", "in", "C0030196#ent", "<e2>", "reduction", "defects", "and", "other", "malformations", "in", "a", "significant", "number", "of", "the", "offspring", "compared", "with", "controls", "."], "h": {"id": "C0722799", "name": "C0722799#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [13, 14]}}
{"token": ["Median", "C1439335#ent", "<e1>", "in", "the", "4", "C2825215#ent", "<e2>", "groups", "did", "not", "differ", "significantly", "."], "h": {"id": "C1439335", "name": "C1439335#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2825215", "name": "C2825215#ent", "pos": [6, 7]}}
{"token": ["A", "fixed", "dose", "of", "lovastatin", "and", "niacin(ER", ")", "significantly", "improved", "cholesterol", "lipoprotein", "lipids", "well", "as", "C1439335#ent", "<e1>", "apoA1/apoB", "levels", "in", "Asian", "Indian", "C2825215#ent", "<e2>", "patients", "."], "h": {"id": "C1439335", "name": "C1439335#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2825215", "name": "C2825215#ent", "pos": [22, 23]}}
{"token": ["In", "several", "species", ",", "C3540778#ent", "<e1>", "act", "directly", "on", "the", "pituitary", "gonadotroph", "suppress", "the", "C1415169#ent", "<e2>", "secretion", "of", "the", "gonadotrophins", ",", "especially", "LH", "."], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [14, 15]}}
{"token": ["Cell", "culture", "studies", "that", "C0136123#ent", "<e1>", "has", "no", "effect", "smooth", "muscle", "proliferation", "but", "increases", "C0009325#ent", "<e2>", "and", "non-collagen", "synthesis", "by", "smooth", "muscle", "cells", "decreases", "their", "binding", "of", "the", "atherogenic", "lipoprotein", "beta-very", "low", "density", "lipoprotein", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0136123", "name": "C0136123#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}}
{"token": ["To", "evaluate", "the", "use", "of", "C0019348#ent", "<e1>", "specific", "serology", "for", "classifying", "first", "episodes", "of", "C0019342#ent", "<e2>", "for", "defining", "C0019348#ent", "<e1>", "serostatus", "in", "the", "patients", "'", "sexual", "partners"], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0019342", "name": "C0019342#ent", "pos": [14, 15]}}
{"token": ["Mutation", "analysis", "the", "corresponding", "C0079429#ent", "<e1>", "in", "the", "patients", "suffering", "from", "C0342737#ent", "<e2>", "no", "mutations", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0342737", "name": "C0342737#ent", "pos": [11, 12]}}
{"token": ["C0524891#ent", "<e1>", "group", "II", "encodes", "a", "C0087071#ent", "<e2>", "LtrA", "protein", ")", "that", "promotes", "RNA", "splicing", "by", "stabilizing", "the", "catalytically", "active", "RNA", "structure", "."], "h": {"id": "C0524891", "name": "C0524891#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0087071", "name": "C0087071#ent", "pos": [6, 7]}}
{"token": ["Pseudohypoparathyroidism", "type", "Ia", "PHP-Ia", ")", ",", "one", "of", "4", "types", "of", "C3494506#ent", "<e1>", ",", "is", "a", "C0019247#ent", "<e2>", "by", "clinical", "hypoparathyroidism", "by", "parathyroid", "hormone", "PTH", ")", "resistance", "."], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [16, 17]}}
{"token": ["C3494506#ent", "<e1>", "PHP", "Ia", ")", "is", "a", "C0019247#ent", "<e2>", "characterised", "by", "resistance", "to", "parathyroid", "hormone", "PTH", ")", ",", "causing", "disturbance", "of", "calcium", "homeostasis", "and", "to", "several", "other", "polypeptide", "hormones"], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["In", "this", "model", ",", "ethanol", "causes", "C2711227#ent", "<e1>", "necrosis", "and", "inflammation", "--", "changes", "characteristic", "of", "C0236970#ent", "<e2>", "human", "beings", "."], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0236970", "name": "C0236970#ent", "pos": [15, 16]}}
{"token": ["C2711227#ent", "<e1>", "NASH", ")", "is", "an", "hepatic", "disorder", "histologic", "features", "of", "C0236970#ent", "<e2>", "occurs", "in", "individuals", "who", "do", "not", "consume", "significant", "alcohol", "."], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0236970", "name": "C0236970#ent", "pos": [11, 12]}}
{"token": ["Betaine", "treatment", "promotes", "removal", "of", "homocysteine", "and", "prevents", "ER", "stress", "C2711227#ent", "<e1>", "and", "apoptosis", "in", "a", "mouse", "model", "C0236970#ent", "<e2>"], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0236970", "name": "C0236970#ent", "pos": [18, 19]}}
{"token": ["Changes", "in", "supine", "systolic", "blood", "pressure", "SSBP", ")", "from", "baseline", "to", "the", "end", "of", "the", "single-therapy", "phase", "were", "10", "mm", "Hg", "for", "the", "C0005320#ent", "<e1>", "and", "16", "mm", "Hg", "for", "the", "C0008294#ent", "<e2>", "group", "."], "h": {"id": "C0005320", "name": "C0005320#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0008294", "name": "C0008294#ent", "pos": [31, 32]}}
{"token": ["Instead", ",", "Spred", "inhibited", "the", "activation", "of", "C0170168#ent", "<e1>", "suppressing", "phosphorylation", "and", "activation", "of", "C1706586#ent", "<e2>", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [14, 15]}}
{"token": ["Pachyonychia", "congenita", "PC", ")", "is", "a", "rare", "C0037274#ent", "<e1>", "with", "characteristic", "nail", "abnormalities", "occasional", "palmoplantar", "keratoderma", "leukokeratosis", "oris", "C0002170#ent", "<e2>", "may", "occur", "(", "10", "%", "of", "patients", ")", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [18, 19]}}
{"token": ["Corrective", "treatment", "unilateral", "thyroidectomy", "did", "not", ",", "however", ",", "resolve", "the", "C0037274#ent", "<e1>", "and", "the", "C0002170#ent", "<e2>", "progressed", "to", "involve", "the", "whole", "ventral", "trunk", ",", "the", "lower", "limbs", "the", "head", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [15, 16]}}
{"token": ["However", ",", "while", "the", "C1706590#ent", "<e1>", "intronless", "in", "A.", "franciscana", ",", "in", "A.", "parthenogenetica", "the", "C0079429#ent", "<e2>", "contained", "a", "mini-intron", "of", "30", "base", "pairs", "in", "the", "3", "'", "non-coding", "region"], "h": {"id": "C1706590", "name": "C1706590#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["Episodic", "ataxia", "type", "1", "a", "C0027765#ent", "<e1>", "by", "short-lived", "attacks", "of", "recurrent", "C0007760#ent", "<e2>", "continuous", "motor", "activity"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007760", "name": "C0007760#ent", "pos": [12, 13]}}
{"token": ["To", "study", "self-reported", "asthma", "C0013595#ent", "<e1>", ",", "and", "pollen", "and", "furry", "pet", "allergy", "C0040416#ent", "<e2>", "(", "9", "-", "20", "years", ")", "in", "Shanxi", "province", ",", "China", ",", "in", "relation", "to", "dietary", "and", "environmental", "factors"], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040416", "name": "C0040416#ent", "pos": [13, 14]}}
{"token": ["By", "expressing", "inhibitory", "mutant", "small", "C0086376#ent", "<e1>", "p21-activated", "kinase", "PAK", ")", "and", "C1417020#ent", "<e2>", "MEKKs", ")", ",", "we", "have", "identified", "specific", "proteins", "that", "are", "involved", "in", "arsenate-", "and", "arsenite-mediated", "activation", "of", "JNK", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417020", "name": "C1417020#ent", "pos": [12, 13]}}
{"token": ["We", "determined", "whether", "C0086376#ent", "<e1>", "encoded", "by", "the", "nm23/nucleoside", "diphosphate", "NDP", ")", "C1417020#ent", "<e2>", "a", "potential", "metastasis-suppressor", "gene", "are", "expressed", "on", "the", "cell", "surface"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417020", "name": "C1417020#ent", "pos": [12, 13]}}
{"token": ["A", "preliminary", "phytochemical", "screening", "of", "the", "C2348140#ent", "<e1>", "P.", "crassipes", "revealed", "the", "presence", "of", "flavonoids", ",", "C0039294#ent", "<e2>", "and", "anthraquinones", "as", "possible", "candidates", "for", "such", "inhibitory", "substances", "."], "h": {"id": "C2348140", "name": "C2348140#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039294", "name": "C0039294#ent", "pos": [16, 17]}}
{"token": ["The", "inhibitory", "effect", "of", "the", "C2348140#ent", "<e1>", "HIV-1", "reverse", "transcriptase", "found", "to", "be", "due", "to", "C0039294#ent", "<e2>", ",", "and", "their", "activities", "were", "stronger", "than", "that", "of", "(-)-epigallocatechin", "gallate", "a", "positive", "control"], "h": {"id": "C2348140", "name": "C2348140#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039294", "name": "C0039294#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "the", "protective", "action", "conventional", "C0014544#ent", "<e1>", "has", "not", "been", "affected", "by", "C0060135#ent", "<e2>", "at", "subprotective", "doses", "against", "maximal", "electroshock", "in", "mice", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0060135", "name": "C0060135#ent", "pos": [14, 15]}}
{"token": ["Since", "glutamate-mediated", "excitation", "is", "involved", "in", "the", "generation", "of", "seizure", "activity", "some", "C0014544#ent", "<e1>", "are", "targeting", "glutamatergic", "receptors", "for", "instance", ",", "C0060135#ent", "<e2>", ",", "phenobarbital", ",", "and", "topiramate", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0060135", "name": "C0060135#ent", "pos": [21, 22]}}
{"token": ["which", "suggested", "that", "the", "hemorheological", "parameters", "in", "patients", "with", "C0020476#ent", "<e1>", "improved", "significantly", "by", "medication", "with", "C0700474#ent", "<e2>"], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0700474", "name": "C0700474#ent", "pos": [16, 17]}}
{"token": ["Dexrazoxane", "(", "C0524711#ent", "<e1>", ",", "Zinecard", ",", "a", "cyclic", "derivative", "edetic", "acid", "is", "a", "site-specific", "C0007209#ent", "<e2>", "effectively", "protects", "against", "anthracycline-induced", "cardiac", "toxicity", "."], "h": {"id": "C0524711", "name": "C0524711#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [15, 16]}}
{"token": ["C0524711#ent", "<e1>", "seems", "to", "be", "a", "useful", "C0007209#ent", "<e2>", "relapsed", "AML", "which", "enables", "further", "treatment", "with", "anthracyclines", "."], "h": {"id": "C0524711", "name": "C0524711#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [7, 8]}}
{"token": ["Only", "hydrocortisone", "and", "C0032950#ent", "<e1>", "suppressed", "LPS", "C1535939#ent", "<e2>", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [7, 8]}}
{"token": ["Perfluorotributylamine/Pluronic", "F68", "Stem-Emulsion", "(", "FC43se", ")", ",", "which", "is", "a", "C0032121#ent", "<e1>", "was", "assessed", "for", "its", "effectiveness", "on", "disseminated", "intravascular", "coagulation", "C0010927#ent", "<e2>", ")", "in", "the", "rat", "model", "."], "h": {"id": "C0032121", "name": "C0032121#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [21, 22]}}
{"token": ["Tyrosinemia", "type", "3", "caused", "by", "a", "genetic", "deficiency", "4-hydroxyphenylpyruvic", "acid", "dioxygenase", "C1415696#ent", "<e1>", ")", "in", "tyrosine", "catabolism", "is", "characterized", "by", "convulsion", ",", "C0007758#ent", "<e2>", ",", "and", "mental", "retardation"], "h": {"id": "C1415696", "name": "C1415696#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [22, 23]}}
{"token": ["It", "has", "been", "reported", "that", "C0003209#ent", "<e1>", "for", "treatment", "of", "pain", "and", "C0231218#ent", "<e2>", "related", "to", "orthodontic", "treatment", "slow", "down", "tooth", "movement"], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [12, 13]}}
{"token": ["Despite", "its", "apparent", "molecular", "weight", "approximately", "10", "C1839259#ent", "<e1>", "the", "chalone", "is", "stable", "against", "denaturing", "agents", "and", "most", "C3540017#ent", "<e2>", ",", "including", "proteases", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [18, 19]}}
{"token": ["Varying", "levels", "of", "cAMP", "were", "used", "in", "these", "assays", "to", "derive", "both", "a", "Vmax", "and", "apparent", "dissociation", "constant", "(", "C1839259#ent", "<e1>", ")", "for", "the", "C3540017#ent", "<e2>", "in", "soluble", "extracts", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [24, 25]}}
{"token": ["While", "beta-catenin", "expression", "remained", "unchanged", ",", "PKC-theta", ",", "a", "C0033634#ent", "<e1>", "was", "evidenced", "to", "increase", "and", "parallel", "C0812229#ent", "<e2>", "level", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812229", "name": "C0812229#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "epinephrine", ",", "glucagon", "and", "insulin", "on", "the", "activity", "and", "degree", "of", "phosphorylation", "of", "C1414544#ent", "<e1>", "in", "isolated", "C0669372#ent", "<e2>", "maintained", "in", "cell", "culture", "24", "h", "were", "investigated", "."], "h": {"id": "C1414544", "name": "C1414544#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [20, 21]}}
{"token": ["The", "index", "case", "a", "41-year-old", "woman", "with", "remittent", "high", "fever", "C0235299#ent", "<e1>", "was", "diagnosed", "as", "Caroli's", "disease", "C0574143#ent", "<e2>", "cholangitis", "based", "on", "findings", "of", "ultrasonography", ",", "computed", "tomography", "endoscopic", "retrograde", "cholangiography"], "h": {"id": "C0235299", "name": "C0235299#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0574143", "name": "C0574143#ent", "pos": [17, 18]}}
{"token": ["DBA/1", "mice", "15", "microg/mouse", "CD200Fc", "at", "3-day", "intervals", "following", "immunization", "with", "C0009325#ent", "<e1>", "did", "not", "develop", "C0003864#ent", "<e2>", "in", "this", "model", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [16, 17]}}
{"token": ["Overexpression", "of", "p38", "MAPK", "and", "an", "activated", "form", "of", "C0173879#ent", "<e1>", "resulted", "in", "activation", "of", "c-jun", "and", "C0087140#ent", "<e2>", "but", "did", "not", "alter", "the", "expression", "of", "the", "glycoprotein", "hormone", "alpha-subunit", "reporter"], "h": {"id": "C0173879", "name": "C0173879#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "in", "the", "presence", "of", "PD", "098059", ",", "a", "specific", "inhibitor", "of", "C0173879#ent", "<e1>", "MEK", ")", ",", "both", "MAPK", "activity", "C0087140#ent", "<e2>", "expression", "were", "blocked", "."], "h": {"id": "C0173879", "name": "C0173879#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [21, 22]}}
{"token": ["A", "specific", "inhibitor", "of", "the", "C0173879#ent", "<e1>", "PD98059", ",", "partially", "inhibited", "the", "induction", "of", "C0087140#ent", "<e2>", "by", "Cd2+"], "h": {"id": "C0173879", "name": "C0173879#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [14, 15]}}
{"token": ["ZVAD", ",", "the", "pancaspase", "inhibitor", "and", "C1704467#ent", "<e1>", "annulled", "the", "effect", "of", "Act", "D", "C1416608#ent", "<e2>", ",", "demonstrating", "a", "role", "for", "cysteine", "proteases", "downstream", "of", "C1704467#ent", "<e1>", "in", "the", "down-regulation", "of", "C1416608#ent", "<e2>", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416608", "name": "C1416608#ent", "pos": [14, 15]}}
{"token": ["Elevated", "levels", "of", "the", "enzyme", "correlated", "directly", "with", "C0030552#ent", "<e1>", "male", "patients", "and", "with", "C0020676#ent", "<e2>", "(", "depressed", "free", "thyroxin", "index", ")", "and", "inversely", "with", "treatment", "with", "vitamin", "D", "supplements", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [14, 15]}}
{"token": ["After", "hemithyroidectomy", ",", "the", "patient", "had", "C0030552#ent", "<e1>", "of", "the", "recurrent", "laryngeal", "nerve", "five", "days", "and", "signs", "of", "C0020676#ent", "<e2>", "and", "hypoparathyroidism", "for", "three", "months", "after", "surgery", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [18, 19]}}
{"token": ["C0030552#ent", "<e1>", "stiffness", "is", "seen", "in", "both", "C0020676#ent", "<e2>", "and", "hyperthyroidism", ",", "and", "muscle", "wasting", "a", "characteristic", "of", "adrenocorticoid", "insufficiency"], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [7, 8]}}
{"token": ["Upon", "tyrosine", "phosphorylation", "C4084735#ent", "<e1>", "recruits", "the", "C4277587#ent", "<e2>", "SHP-1", ")", "that", "is", "involved", "in", "negative", "signaling"], "h": {"id": "C4084735", "name": "C4084735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4277587", "name": "C4277587#ent", "pos": [7, 8]}}
{"token": ["Nontransformed", "osteoblasts", "and", "Saos2", "or", "MG63", "cells", "expressed", "C1366480#ent", "<e1>", "in", "response", "to", "C1705340#ent", "<e2>", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [13, 14]}}
{"token": ["It", "binds", "to", "C1706331#ent", "<e1>", "with", "higher", "affinity", "than", "C0035334#ent", "<e2>", ",", "and", "recognizes", "a", "larger", "fragment", "that", "contains", "fibrin", "and", "collagen", "binding", "domains"], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [9, 10]}}
{"token": ["C0022478#ent", "<e1>", "mRNA", "was", "demonstrated", "by", "reverse", "transcriptase/polymerase", "chain", "reaction", "uteri", "of", "nonpregnant", "and", "C1424742#ent", "<e2>", "rats", "."], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424742", "name": "C1424742#ent", "pos": [14, 15]}}
{"token": ["We", "have", "reported", "that", "peroxynitrite", "(", "C3890206#ent", "<e1>", ")", "selectively", "inactivated", "C0072259#ent", "<e2>", "PGIS", ")", "by", "a", "mechanism", "of", "tyrosine", "nitration", "the", "active", "site", "Zou", ",", "Martin", "and", "Ullrich", "(", "1997", ")", "Biol", "."], "h": {"id": "C3890206", "name": "C3890206#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072259", "name": "C0072259#ent", "pos": [11, 12]}}
{"token": ["Minocycline", "inhibited", "IFNgamma-induced", "PKC(alpha/betaII", ")", "phosphorylation", "and", "the", "nuclear", "translocation", "both", "PKC(alpha/betaII", ")", "and", "C1706474#ent", "<e1>", "that", "subsequently", "inhibits", "C1824738#ent", "<e2>", "expression", "."], "h": {"id": "C1706474", "name": "C1706474#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1824738", "name": "C1824738#ent", "pos": [19, 20]}}
{"token": ["However", ",", "inhibition", "of", "PKCdelta", "did", "not", "affect", "C1706474#ent", "<e1>", "expression", "or", "C1706474#ent", "<e1>", "binding", "to", "the", "C1824738#ent", "<e1>", "promoter", "."], "h": {"id": "C1706474", "name": "C1706474#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1824738", "name": "C1824738#ent", "pos": [17, 18]}}
{"token": ["These", "studies", "demonstrate", "the", "restoration", "of", "C0684287#ent", "<e1>", "in", "human", "C0037231#ent", "<e2>", "the", "concept", "of", "gene", "therapy", "a", "potential", "future", "treatment", "option", "for", "SLS", "."], "h": {"id": "C0684287", "name": "C0684287#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037231", "name": "C0037231#ent", "pos": [10, 11]}}
{"token": ["Differential", "centrifugation", "studies", "in", "fibroblasts", "indicated", "that", "this", "C0684287#ent", "<e1>", "enzyme", "was", "largely", "particulate", ";", "soluble", "C0684287#ent", "<e1>", "activity", "was", "normal", "in", "C0037231#ent", "<e1>"], "h": {"id": "C0684287", "name": "C0684287#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037231", "name": "C0037231#ent", "pos": [22, 23]}}
{"token": ["Significantly", ",", "phosphorylation", "of", "Tiam1", "by", "Ca2+/calmodulin-dependent", "protein", "kinase", "II", "but", "not", "by", "C1259877#ent", "<e1>", "enhanced", "its", "nucleotide", "exchange", "activity", "C1419407#ent", "<e2>", ",", "by", "approximately", "2-fold", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1419407", "name": "C1419407#ent", "pos": [20, 21]}}
{"token": ["Hypothermic", "effects", "d-Amphetamine", ",", "C0033229#ent", "<e1>", ",", "a", "variety", "of", "other", "C0031436#ent", "<e2>", ",", "ET495", "and", "haloperidol", "in", "rats", "at", "4", "degrees", "C", "were", "measured", "separately", "and", "in", "combination", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [4, 5]}, "relation": "has_structural_class", "t": {"id": "C0031436", "name": "C0031436#ent", "pos": [11, 12]}}
{"token": ["The", "results", "of", "this", "study", "show", "that", "C0033229#ent", "<e1>", "is", "actively", "transported", "my", "P-glycoprotein", "and", "that", "chemosensitization", "by", "C0031436#ent", "<e2>", "may", "occur", "by", "competition", "of", "these", "agents", "for", "active", "transport", "anticancer", "agents", "P-glycoprotein", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [7, 8]}, "relation": "has_structural_class", "t": {"id": "C0031436", "name": "C0031436#ent", "pos": [18, 19]}}
{"token": ["Ibuprofen", "attenuated", "lung-tissue", "malondialdehyde", "had", "no", "effect", "on", "lung", "inflammation", "circulating", "lipid", "peroxides", "C0013604#ent", "<e1>", "indicating", "that", "C0020740#ent", "<e2>", "most", "likely", "decreased", "O2", "radical", "release", "in", "lung", "tissue", "the", "already-sequestered", "neutrophils", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [17, 18]}}
{"token": ["The", "differential", "diagnosis", "left", "lower", "quadrant", "abdominal", "pain", "an", "adult", "man", "includes", ",", "among", "others", ",", "sigmoid", "diverticulitis", "leaking", "abdominal", "aortic", "aneurysm", "renal", "colic", "epididymitis", ";", "incarcerated", "hernia", "bowel", "obstruction", "regional", "enteritis", "C0085222#ent", "<e1>", "and", "in", "this", "rare", "instance", ",", "situs", "inversus", "C0085693#ent", "<e2>"], "h": {"id": "C0085222", "name": "C0085222#ent", "pos": [32, 33]}, "relation": "NA", "t": {"id": "C0085693", "name": "C0085693#ent", "pos": [42, 43]}}
{"token": ["C0618111#ent", "<e1>", "is", "a", "non-steroidal", "selective", "estrogen", "receptor", "modulator", "SERM", ")", "that", "mimics", "estrogenic", "activity", "bone", "density", "C0684286#ent", "<e2>", "without", "uterotropic", "actions", "."], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0684286", "name": "C0684286#ent", "pos": [17, 18]}}
{"token": ["In", "the", "present", "case", ",", "with", "RIA", "determination", "of", "plasma", "ACTH", "concentrations", ",", "the", "C0039082#ent", "<e1>", "was", "ascribed", "to", "pituitary", "ACTH-dependent", "hyperadrenocorticism", "likened", "to", "human", "C0271725#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0271725", "name": "C0271725#ent", "pos": [25, 26]}}
{"token": ["Four", "patients", "each", "with", "adrenal", "adenomas", "three", "patients", "with", "the", "ectopic", "C0039082#ent", "<e1>", "to", "suppress", ",", "while", "a", "child", "with", "probable", "C0271725#ent", "<e2>", "a", "variable", "response", "depending", "on", "the", "dose", "used", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0271725", "name": "C0271725#ent", "pos": [21, 22]}}
{"token": ["Expression", "of", "C1419150#ent", "<e1>", "mutants", "that", "disrupt", "C1705791#ent", "<e2>", "association", "or", "phosphorylation", "inhibits", "HGF-induced", "cell", "spreading", ",", "migration", ",", "and", "tubulogenesis", "."], "h": {"id": "C1419150", "name": "C1419150#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [7, 8]}}
{"token": ["The", "level", "of", "C1412179#ent", "<e1>", "ADA", ")", "and", "arylsulphatase", "A", "C0007804#ent", "<e2>", ")", "in", "the", "sera", "of", "22", "patients", "with", "acute", "lymphoblastic", "leukemia", "ALL", ")", "were", "significantly", "increased", "when", "compared", "with", "the", "control", "healthy", "."], "h": {"id": "C1412179", "name": "C1412179#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [10, 11]}}
{"token": ["The", "level", "of", "C1412179#ent", "<e1>", "ADA", ")", "and", "C0007804#ent", "<e2>", "ASA", ")", "in", "the", "sera", "of", "22", "patients", "with", "acute", "lymphoblastic", "leukemia", "ALL", ")", "were", "significantly", "increased", "when", "compared", "with", "the", "control", "healthy", "."], "h": {"id": "C1412179", "name": "C1412179#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [8, 9]}}
{"token": ["Wild-type", "and", "Pxr-null", "mice", "were", "treated", "with", "PXR", "agonist", "pregnenolone-16alpha-carbonitrile", "or", "vehicle", "and", "administered", "2.5", "%", "dextran", "sulfate", "sodium", "C1848296#ent", "<e1>", ")", "in", "drinking", "water", "induce", "C0022104#ent", "<e2>", "."], "h": {"id": "C1848296", "name": "C1848296#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [26, 27]}}
{"token": ["Maturation", "factors", "result", "in", "unusual", "C0014544#ent", "<e1>", "manifestations", ",", "for", "example", ",", "C0037769#ent", "<e2>", "hypsarrhythmia", "caused", "by", "a", "focal", "cortical", "lesion", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0037769", "name": "C0037769#ent", "pos": [12, 13]}}
{"token": ["An", "\"", "awakening", "seizure", "\"", "could", "be", "confirmed", "in", "27", "children", ",", "including", "18", "with", "various", "C0014544#ent", "<e1>", "and", "9", "infants", "with", "C0037769#ent", "<e2>"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0037769", "name": "C0037769#ent", "pos": [22, 23]}}
{"token": ["In", "androgenetic", "alopecia", "C1516876#ent", "<e1>", "marked", "hair", "follicles", "progressive", ",", "androgen-mediated", "miniaturization", "C0002842#ent", "<e2>", "have", "been", "conventionally", "sought", "to", "intercept", "this", "process", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [12, 13]}}
{"token": ["The", "process", "of", "sexual", "differentiation", "leaves", "C1516876#ent", "<e1>", "female", "individuals", "at", "risk", "of", "being", "masculinized", "by", "exogenous", "C0002842#ent", "<e2>", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [17, 18]}}
{"token": ["To", "examine", "the", "function", "of", "MIZF", "in", "regulating", "C2985443#ent", "<e1>", "we", "transduced", "C2C12", "myoblasts", "with", "adenoviral", "vectors", "C0669365#ent", "<e2>", "produce", "MIZF", "at", "high", "levels"], "h": {"id": "C2985443", "name": "C2985443#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}}
{"token": ["A", "stable", "cell", "system", "also", "developed", "in", "which", "C2985443#ent", "<e1>", "expression", "was", "C0669365#ent", "<e2>", ",", "while", "myc", "levels", "could", "be", "elevated", "conditionally", "."], "h": {"id": "C2985443", "name": "C2985443#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}}
{"token": ["We", "previously", "reported", "that", "the", "phorbol", "ester", "12-O-tetradecanoylphorbol-13-acetate", "TPA", ")", "induces", "growth", "arrest", "C2985443#ent", "<e1>", "these", "cells", ",", "which", "C0669365#ent", "<e2>", "express", "muscle", "regulatory", "factors"], "h": {"id": "C2985443", "name": "C2985443#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [19, 20]}}
{"token": ["This", "study", "tested", "the", "hypothesis", "that", "severe", "C0031099#ent", "<e1>", "in", "persons", "with", "non-insulin-dependent", "diabetes", "mellitus", "C3273872#ent", "<e2>", ")", "increases", "the", "risk", "of", "poor", "glycemic", "control"], "h": {"id": "C0031099", "name": "C0031099#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [15, 16]}}
{"token": ["We", "have", "described", "a", "patient", "with", "C0876973#ent", "<e1>", "probably", "blastomycosis", ",", "with", "C0553548#ent", "<e2>", "the", "skin", "."], "h": {"id": "C0876973", "name": "C0876973#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0553548", "name": "C0553548#ent", "pos": [12, 13]}}
{"token": ["The", "emergencies", "could", "also", "result", "from", "use", "of", "C0003451#ent", "<e1>", "lactic", "acidosis", "pancreatitis", ",", "bone", "marrow", "suppression", "may", "include", "the", "C1619738#ent", "<e2>"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1619738", "name": "C1619738#ent", "pos": [20, 21]}}
{"token": ["The", "C0003451#ent", "<e1>", "themselves", "be", "toxic", "or", "cause", "an", "C1619738#ent", "<e2>", "needs", "to", "be", "distinguished", "from", "HIV", "dementia"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1619738", "name": "C1619738#ent", "pos": [9, 10]}}
{"token": ["The", "large", "amount", "of", "Ca(2+)-independent", "C0243051#ent", "<e1>", "release", "observed", "in", "the", "C1427947#ent", "<e2>", "mutants", "suggests", "that", "there", "may", "be", "a", "distinct", "mechanism", "from", "evoked", "or", "spontaneous", "release", "in", "neurotransmission", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1427947", "name": "C1427947#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "if", "a", "similar", "protein", "is", "a", "component", "of", "the", "presynaptic", "machinery", "for", "C0243051#ent", "<e1>", "release", "in", "vertebrates", ",", "we", "studied", "C1427947#ent", "<e2>", "rat", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1427947", "name": "C1427947#ent", "pos": [22, 23]}}
{"token": ["The", "degradation", "of", "C0002245#ent", "<e1>", "progresses", "by", "the", "co-operation", "of", "two", "C3542456#ent", "<e2>", ":", "glycogen", "phosphorylase", "phosphorylase", ")", "and", "glycogen", "debranching", "enzyme", "GDE", ")", "."], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3542456", "name": "C3542456#ent", "pos": [11, 12]}}
{"token": ["C1709407#ent", "<e1>", "is", "a", "C1417585#ent", "<e2>", "elicits", "antiproliferative", "activity", "is", "a", "potential", "tumor", "suppressor", "gene"], "h": {"id": "C1709407", "name": "C1709407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417585", "name": "C1417585#ent", "pos": [4, 5]}}
{"token": ["C1709407#ent", "<e1>", "is", "a", "C1417585#ent", "<e2>", "induces", "apoptosis", "and", "cell", "cycle", "arrest", "various", "cell", "lines"], "h": {"id": "C1709407", "name": "C1709407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417585", "name": "C1417585#ent", "pos": [4, 5]}}
{"token": ["Using", "mutational", "analysis", "we", "have", "investigated", "the", "molecular", "basis", "two", "immunoreactive", "forms", "of", "murine", "C0084219#ent", "<e1>", "of", "56", "and", "59", "kDa", "found", "in", "numerous", "C0812317#ent", "<e2>"], "h": {"id": "C0084219", "name": "C0084219#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812317", "name": "C0812317#ent", "pos": [24, 25]}}
{"token": ["RNase", "protection", "analysis", "established", "that", "C0084219#ent", "<e1>", "transcripts", "initiate", "from", "heterogeneous", "start", "sites", "located", "within", "the", "C0812317#ent", "<e2>"], "h": {"id": "C0084219", "name": "C0084219#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812317", "name": "C0812317#ent", "pos": [16, 17]}}
{"token": ["The", "addition", "of", "progesterone", "to", "plasma", "samples", "of", "non-pregnant", "volunteers", "not", "influence", "the", "free", "fraction", "bupivacaine", ",", "whereas", "the", "addition", "of", "C1418186#ent", "<e1>", "the", "plasma", "of", "C0030612#ent", "<e2>", "decreased", "the", "free", "fraction", "."], "h": {"id": "C1418186", "name": "C1418186#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0030612", "name": "C0030612#ent", "pos": [26, 27]}}
{"token": ["The", "high-risk", "group", "patients", "should", "be", "carefully", "monitored", "within", "the", "first", "six", "days", "after", "the", "onset", "of", "symptoms", "of", "C0340293#ent", "<e1>", "in", "an", "effort", "to", "prevent", "C0018814#ent", "<e2>"], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0018814", "name": "C0018814#ent", "pos": [26, 27]}}
{"token": ["The", "carcinogenic", "potential", "of", "gamma-oryzanol", ",", "a", "C1254351#ent", "<e1>", "mainly", "used", "for", "the", "treatment", "of", "C0020473#ent", "<e2>", ",", "was", "studied", "in", "B6C3F1", "mice", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [15, 16]}}
{"token": ["These", "modulations", "of", "lipid", "content", "serum", "lipoproteins", "the", "C1254351#ent", "<e1>", "suggest", "a", "favorable", "situation", "for", "treatment", "of", "C0020473#ent", "<e2>", "states", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "the", "C0206526#ent", "<e1>", "or", "-sensitive", "cells", "with", "equitoxic", "doses", "of", "C0127565#ent", "<e2>", "or", "teniposide", "results", "in", "a", "G(2)/M", "arrest", "."], "h": {"id": "C0206526", "name": "C0206526#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0127565", "name": "C0127565#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "C0049894#ent", "<e1>", "attenuated", "locomotion", "produced", "by", "high", "doses", "C0003596#ent", "<e2>", "."], "h": {"id": "C0049894", "name": "C0049894#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [10, 11]}}
{"token": ["Quinpirole", ",", "C0049894#ent", "<e1>", ",", "bromocriptine", "and", "C0003596#ent", "<e2>", "partially", "blocked", "the", "stimulus", "effects", "of", "tiapride", "whereas", "SKF", "38393", "did", "not", "affect", "the", "discrimination", "."], "h": {"id": "C0049894", "name": "C0049894#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [7, 8]}}
{"token": ["To", "investigate", "the", "function", "of", "histone", "deacetylases", "C1422386#ent", "<e1>", ")", "inhibitor", "FK228", "in", "the", "C0357126#ent", "<e2>", "mediated", "proliferation", "and", "differentiation", "of", "human", "erythroid", "progenitor"], "h": {"id": "C1422386", "name": "C1422386#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0357126", "name": "C0357126#ent", "pos": [14, 15]}}
{"token": ["No", "evidence", "was", "obtained", "for", "the", "intervention", "or", "contribution", "of", ".OH-like", "radicals", ",", "C3711796#ent", "<e1>", "and", "oxidized", "glutathione", "the", "transformation", "of", "the", "zymogens", "into", "C3540790#ent", "<e2>", "able", "to", "inactivate", "A1AT", "."], "h": {"id": "C3711796", "name": "C3711796#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [24, 25]}}
{"token": ["Subsequently", ",", "the", "807", "C2827459#ent", "<e1>", "found", "to", "be", "associated", "with", "coronary", "artery", "disease", "CAD", ")", "and", "C0007785#ent", "<e2>", "younger", "patients", "."], "h": {"id": "C2827459", "name": "C2827459#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [17, 18]}}
{"token": ["Dodecanoic", "acid", "present", "at", "about", "1200", "ppb", ",", "C0067869#ent", "<e1>", "was", "approximately", "1000", "ppb", ",", "C1880232#ent", "<e2>", ",", "benzophenone", "and", "methyl", "salicylate", "above", "800", "ppb", ",", "and", "2-methyl-naphthalene", "near", "215", "ppb", "."], "h": {"id": "C0067869", "name": "C0067869#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1880232", "name": "C1880232#ent", "pos": [15, 16]}}
{"token": ["RfbAKpO1", "is", "predicted", "to", "be", "an", "C1823138#ent", "<e1>", "five", "putative", "membrane-spanning", "domains", "its", "C0021699#ent", "<e2>", "confirmed", "by", "TnphoA", "mutagenesis", "."], "h": {"id": "C1823138", "name": "C1823138#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [13, 14]}}
{"token": ["Binding", "affinity", "between", "ahnak-C1", "(", "aa", "4646", "-", "5288", ")", "and", "C1417683#ent", "<e1>", "decreased", "by", "approximately", "50", "%", "after", "C0010531#ent", "<e2>", "phosphorylation", "or", "in", "the", "presence", "of", "Ile5236Thr-ahnak", "peptide", "."], "h": {"id": "C1417683", "name": "C1417683#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [19, 20]}}
{"token": ["C0067685#ent", "<e1>", "levels", "in", "astrocyte", "and", "oligodendrocyte", "cultures", "remained", "unchanged", "after", "C2697656#ent", "<e2>", "treatment", "."], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [11, 12]}}
{"token": ["Doses", "of", "these", "three", "antagonists", "were", "selected", "to", "produce", "a", "comparable", "degree", "of", "the", "negative", "chrono-", "and", "inotropic", "effect", "a", "different", "potency", "of", "alpha-adrenoceptor", "blockade", "C0022860#ent", "<e1>", "greater", "than", "C0104221#ent", "<e2>", ")", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0104221", "name": "C0104221#ent", "pos": [29, 30]}}
{"token": ["We", "describe", "two", "unrelated", "male", "children", "with", "C0431401#ent", "<e1>", "a", "rare", "genetic", "disorder", "of", "C0007758#ent", "<e2>", "partial", "aniridia", "and", "psychomotor", "delay"], "h": {"id": "C0431401", "name": "C0431401#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [14, 15]}}
{"token": ["The", "results", "showed", "that", "a", "single", "early", "MA", "challenge", "significantly", "C2712370#ent", "<e1>", "maturation", "of", "dopamine", "fibre", "innervation", "in", "both", "subregions", "of", "the", "C1622105#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [22, 23]}}
{"token": ["C0919524#ent", "<e1>", "Rad3", "related", "(ATR)-Seckel", "syndrome", "and", "C3711387#ent", "<e2>", "MCPH", ")", "syndrome", "share", "clinical", "features", "."], "h": {"id": "C0919524", "name": "C0919524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3711387", "name": "C3711387#ent", "pos": [7, 8]}}
{"token": ["Repigmentation", "occurred", "within", "a", "few", "weeks", "of", "discontinuing", "successful", "depigmentation", "therapy", "C0050962#ent", "<e1>", "in", "a", "patient", "with", "extensive", "C0042900#ent", "<e2>", "."], "h": {"id": "C0050962", "name": "C0050962#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [18, 19]}}
{"token": ["Confirming", "the", "inhibitory", "nature", "of", "C1413816#ent", "<e1>", ",", "point", "mutations", "that", "destabilize", "C1413816#ent", "<e1>", "promote", "exon", "7", "inclusion", "in", "C1420258#ent", "<e1>", ",", "whereas", "strengthening", "of", "C1413816#ent", "<e1>", "promotes", "exon", "7", "even", "in", "SMN1", "."], "h": {"id": "C1413816", "name": "C1413816#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420258", "name": "C1420258#ent", "pos": [19, 20]}}
{"token": ["C0072032#ent", "<e1>", "was", "a", "weak", ",", "partial", "C2987634#ent", "<e2>", "in", "the", "bovine", "coronary", "artery", "rabbit", "atria", "and", "a", "potent", ",", "full", "C2987634#ent", "<e2>", "in", "the", "guinea", "pig", "trachea", "."], "h": {"id": "C0072032", "name": "C0072032#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}}
{"token": ["It", "is", "concluded", "that", "C0072032#ent", "<e1>", "can", "be", "a", "good", "alternative", "beta-2-adrenoceptor", "C2987634#ent", "<e2>", "when", "the", "oral", "route", "needed", "."], "h": {"id": "C0072032", "name": "C0072032#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [12, 13]}}
{"token": ["Although", "C0072032#ent", "<e1>", "is", "used", "clinically", "as", "a", "beta(2)-adrenergic", "receptor", "C2987634#ent", "<e2>", "to", "relax", "airway", "smooth", "muscle", "it", "has", "not", "yet", "been", "clarified", "whether", "C0072032#ent", "<e1>", "has", "inotropic", "effects", "respiratory", "muscles"], "h": {"id": "C0072032", "name": "C0072032#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}}
{"token": ["Although", "the", "leucine", "zipper", "that", "C3537219#ent", "<e1>", "may", "act", "as", "a", "C1413746#ent", "<e2>", "our", "data", "do", "not", "support", "a", "direct", "interaction", "with", "the", "ICRE", "."], "h": {"id": "C3537219", "name": "C3537219#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413746", "name": "C1413746#ent", "pos": [11, 12]}}
{"token": ["In", "several", "clinical", "studies", "C0014868#ent", "<e1>", "candidemia", "and", "invasive", "candidiasis", "the", "clinical", "efficacy", "this", "C1268551#ent", "<e2>", "was", "similar", ",", "or", "even", "superior", ",", "to", "that", "of", "established", "antifungals", "in", "candidemia", "."], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1268551", "name": "C1268551#ent", "pos": [14, 15]}}
{"token": ["C0812306#ent", "<e1>", ",", "which", "is", "selected", "together", "with", "mature", "C1956063#ent", "<e2>", "by", "A-TH", "among", "labelled", "proteins", "in", "vivo", "differs", "from", "THP1", "in", "apparent", "mol", "."], "h": {"id": "C0812306", "name": "C0812306#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1956063", "name": "C1956063#ent", "pos": [9, 10]}}
{"token": ["CD43-mediated", "homotypic", "aggregation", "T", "lymphocytes", "the", "participation", "of", "Src", "kinases", "C0250414#ent", "<e1>", "protein", "kinase", "C", "phosphatidylinositol-3", "kinase", "as", "well", "as", "extracellular-regulated", "kinase", "1/2", "C1366876#ent", "<e2>", "."], "h": {"id": "C0250414", "name": "C0250414#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [23, 24]}}
{"token": ["This", "occurs", "in", "the", "absence", "of", "detectable", "TNFR1", "expression", ",", "suggesting", "that", "C1332372#ent", "<e1>", "could", "interact", "with", "other", "C0086376#ent", "<e2>", "at", "these", "sites", "."], "h": {"id": "C1332372", "name": "C1332372#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [18, 19]}}
{"token": ["MIP-2", "and", "C1705593#ent", "<e1>", "mediated", "the", "infiltration", "of", "neutrophils", "into", "the", "epidermis", ",", "since", "this", "was", "prevented", "by", "ablating", "C1334126#ent", "<e2>", "in", "K5-PKCalpha", "mice", "or", "administering", "neutralizing", "antibodies", "C1705593#ent", "<e1>", "or", "MIP-2", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705593", "name": "C1705593#ent", "pos": [2, 3]}}
{"token": ["UTI", "induced", "increases", "in", "the", "renal", "concentrations", "the", "C1334126#ent", "<e1>", "ligands", "macrophage", "inflammatory", "protein-2", "and", "C1705593#ent", "<e2>", ",", "which", "were", "not", "influenced", "by", "anti-CXCR2", "administration", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705593", "name": "C1705593#ent", "pos": [15, 16]}}
{"token": ["We", "used", "a", "typing", "scheme", "based", "on", "tests", "for", "C0005220#ent", "<e1>", ",", "hippurate", "hydrolysis", "and", "lipase", ",", "using", "C0220884#ent", "<e2>", "as", "a", "substrate", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220884", "name": "C0220884#ent", "pos": [18, 19]}}
{"token": ["The", "C0012892#ent", "<e1>", "of", "the", "parental", "HIV-1", "and", "HIV-2", "C0032339#ent", "<e2>", "was", "similar", ";", "as", "expected", ",", "the", "specific", "activity", "of", "the", "polymerases", "of", "all", "the", "hybrid", "C0032339#ent", "<e2>", "were", "also", "similar", "."], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0032339", "name": "C0032339#ent", "pos": [9, 10]}}
{"token": ["Early", "embryos", "(", "four", "to", "eight", "cells", ")", "were", "randomly", "allocated", "to", "bovine", "granulosa", "cell", "GC", ")", ",", "oviductal", "cell", "C1412791#ent", "<e1>", ")", ",", "or", "uterine", "cell", "UC", ")", "C0872351#ent", "<e2>", "in", "Exp", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [29, 30]}}
{"token": ["To", "characterize", "organic", "cation", "C1412791#ent", "<e1>", ")", "transport", "in", "primary", "cultured", "rabbit", "alveolar", "epithelial", "cell", "C0872351#ent", "<e2>", ",", "using", "[14C]-guanidine", "as", "a", "model", "substrate", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [15, 16]}}
{"token": ["The", "complications", "of", "painful", "crisis", "C0002888#ent", "<e1>", "hallmarks", "of", "the", "pregnant", "patient", "C0019045#ent", "<e2>"], "h": {"id": "C0002888", "name": "C0002888#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019045", "name": "C0019045#ent", "pos": [12, 13]}}
{"token": ["The", "recommended", "treatment", "iron", "deficiency", "C0002871#ent", "<e1>", "and", "moderate", "C0235950#ent", "<e2>", "supplementation", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235950", "name": "C0235950#ent", "pos": [9, 10]}}
{"token": ["Laboratory", "findings", "C0002871#ent", "<e1>", ",", "hypoproteinaemia", "and", "C0235950#ent", "<e2>"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235950", "name": "C0235950#ent", "pos": [7, 8]}}
{"token": ["In", "a", "Transwell", "migration", "test", ",", "C1417807#ent", "<e1>", "also", "increased", "the", "cell", "migration", "and", "C1418403#ent", "<e2>", ",", "wortmannin", ",", "and", "PD-98059", "blocked", "this", "increase", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418403", "name": "C1418403#ent", "pos": [14, 15]}}
{"token": ["As", "a", "result", ",", "DEAD", "(", "Asp-Glu-Ala-Asp/His", ")", "box", "polypeptide", "47", "(", "C4284023#ent", "<e1>", "47", ")", ",", "recently", "identified", "as", "C0084378#ent", "<e2>", "is", "identified", "as", "a", "binding", "partner", "of", "GABARAP", "."], "h": {"id": "C4284023", "name": "C4284023#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0084378", "name": "C0084378#ent", "pos": [20, 21]}}
{"token": ["Based", "on", "the", "sequence", "of", "the", "helicase", "domain", "they", "are", "classified", "into", "families", ",", "such", "as", "C4284023#ent", "<e1>", "and", "DHX", "families", "of", "human", "C0084378#ent", "<e2>"], "h": {"id": "C4284023", "name": "C4284023#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0084378", "name": "C0084378#ent", "pos": [23, 24]}}
{"token": ["Members", "of", "human", "C4284023#ent", "<e1>", "and", "DHX", "families", "of", "C0084378#ent", "<e2>", "roles", "in", "differentiation", "and", "carcinogenesis", "."], "h": {"id": "C4284023", "name": "C4284023#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0084378", "name": "C0084378#ent", "pos": [9, 10]}}
{"token": ["Two", "sites", "of", "cleavage", "in", "the", "sequence", "of", "gelatin", ",", "Gly-Ile", "and", "C0061736#ent", "<e1>", ",", "have", "been", "positively", "identified", "using", "synthetic", "substrates", "tryptic", "peptides", "C0009325#ent", "<e2>", "."], "h": {"id": "C0061736", "name": "C0061736#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [24, 25]}}
{"token": ["Chronic", "C0010592#ent", "<e1>", "treatment", "significantly", "increased", "renal", "kallikrein", "bradykinin", "B2", "receptor", "and", "C0086509#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086509", "name": "C0086509#ent", "pos": [12, 13]}}
{"token": ["Histological", "relations", "C1412115#ent", "<e1>", "clones", "and", "the", "colocalization", "of", "each", "ASIC", "subunit", "C1421467#ent", "<e2>", "within", "single", "sensory", "neurons", "were", "examined", "on", "serial", "sections", "of", "rat", "dorsal", "root", "ganglia", "DRG", ")", "using", "in", "situ", "hybridization", "histochemistry"], "h": {"id": "C1412115", "name": "C1412115#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421467", "name": "C1421467#ent", "pos": [12, 13]}}
{"token": ["C0030883#ent", "<e1>", "blocked", "the", "increase", "in", "C1428360#ent", "<e2>", "produced", "by", "physostigmine", ",", "but", "had", "no", "effect", "on", "that", "produced", "by", "pilocarpine", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [6, 7]}}
{"token": ["Serum", "and", "C0020197#ent", "<e1>", "levels", "were", "not", "significantly", "different", "in", "normal", "and", "C1538879#ent", "<e2>", "patients", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1538879", "name": "C1538879#ent", "pos": [12, 13]}}
{"token": ["TNF-alpha", ",", "sphingomyelinase", ",", "and", "C(2)-ceramide", "translocated", "Cdc42", ",", "C0285558#ent", "<e1>", ",", "and", "RhoA", "to", "membranes", ",", "and", "stimulated", "C1337052#ent", "<e2>", "of", "Ras-GTP", ",", "PI", "3-K", ",", "and", "SK", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1337052", "name": "C1337052#ent", "pos": [19, 20]}}
{"token": ["Laboratories", "play", "a", "crucial", "role", "in", "the", "diagnosis", "of", "congenital", "and", "C0010823#ent", "<e1>", "considering", "that", "other", "C0042769#ent", "<e2>", "newborn", "infants", "similar", "clinical", "characteristics"], "h": {"id": "C0010823", "name": "C0010823#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [16, 17]}}
{"token": ["Studies", "with", "low", "molecular", "weight", "inhibitors", "the", "importance", "of", "C1332829#ent", "<e1>", "and", "CYP3A", "in", "C0010980#ent", "<e2>", "N-hydroxylation", "."], "h": {"id": "C1332829", "name": "C1332829#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [14, 15]}}
{"token": ["We", "report", "the", "development", "of", "a", "fusion", "protein", "Hc", "and", "C1332397#ent", "<e1>", "to", "enhance", "uptake", "of", "C1332397#ent", "<e1>", "by", "C0025237#ent", "<e1>", "as", "a", "strategy", "for", "inhibiting", "peripheral", "neuronal", "apoptosis"], "h": {"id": "C1332397", "name": "C1332397#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025237", "name": "C0025237#ent", "pos": [19, 20]}}
{"token": ["We", "found", "Borrelias", "in", "the", "dermis", "of", "Pick-Herxheimer", "disease", "(", "3/3", ")", ",", "C0014740#ent", "<e1>", "6/9", ")", ",", "lymphocytoma", "(", "1/3", ")", ",", "and", "C0036420#ent", "<e2>", "(", "2/5", ")", "."], "h": {"id": "C0014740", "name": "C0014740#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0036420", "name": "C0036420#ent", "pos": [24, 25]}}
{"token": ["Fiftyone", "patients", "with", "a", "diagnosis", "of", "C0014740#ent", "<e1>", "ECM", ")", ",", "lymphadenosis", "cutis", "benigna", "LABC", ")", ",", "systemic", "progressive", "sclerosis", "C0036420#ent", "<e2>", "lichen", "sclerosus", "atrophicans", "were", "investigated", "in", "order", "to", "obtain", "serological", "evaluation", "of", "Borrelia", "burgdorferi", "circulating", "antibodies"], "h": {"id": "C0014740", "name": "C0014740#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036420", "name": "C0036420#ent", "pos": [20, 21]}}
{"token": ["The", "eruption", "may", "mimic", "other", "dermatoses", "including", "granuloma", "annulare", "C0014740#ent", "<e1>", "and", "the", "inflammatory", "stage", "C0036420#ent", "<e2>", "."], "h": {"id": "C0014740", "name": "C0014740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036420", "name": "C0036420#ent", "pos": [15, 16]}}
{"token": ["Mutations", "of", "the", "human", "SLC4A1", "gene", "erythroid", "and", "C0597298#ent", "<e1>", "anion", "exchanger", "1", "AE1", ",", "band", "3", "result", "in", "erythrocyte", "abnormalities", "distal", "renal", "tubular", "acidosis", "C0058442#ent", "<e2>", ")", "and", "such", "mutations", "are", "observed", "in", "Southeast", "Asia", "where", "hemoglobinopathies", "are", "prevalent", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0058442", "name": "C0058442#ent", "pos": [25, 26]}}
{"token": ["Two", "C0029007#ent", "<e1>", "encoded", "by", "the", "C1705982#ent", "<e2>", "p21K-rasA", "and", "p21K-rasB", ")", "due", "to", "alternative", "splicing", "of", "the", "last", "exon", "."], "h": {"id": "C0029007", "name": "C0029007#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705982", "name": "C1705982#ent", "pos": [6, 7]}}
{"token": ["The", "interferon", "(IFN)-inducible", "double-stranded", "(ds)", "RNA-activated", "protein", "kinase", "p68", "kinase", "is", "a", "physiologically", "important", "C0014442#ent", "<e1>", "that", "regulates", "the", "rate", "of", "cellular", "and", "C0079405#ent", "<e2>", "synthesis", "by", "phosphorylating", "and", "thereby", "inactivating", "the", "peptide", "chain", "initiation", "factor", "2"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079405", "name": "C0079405#ent", "pos": [23, 24]}}
{"token": ["Experiments", "have", "been", "performed", "to", "determine", "whether", "the", "antisecretory", "(", "C0011991#ent", "<e1>", ")", "actions", "of", "difenoxin", "and", "C0023992#ent", "<e2>", "are", "mediated", "by", "enteric", "neurones", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0023992", "name": "C0023992#ent", "pos": [17, 18]}}
{"token": ["Fifty-three", "young", "children", "with", "C0011991#ent", "<e1>", "included", "in", "a", "hospital-based", ",", "double-blind", "trial", "C0023992#ent", "<e2>", "at", "two", "dose", "levels", "0.4", "and", "0.8", "mg/kg/day", ")", ",", "given", "with", "standard", "oral", "rehydration", "therapy", "placebo", "plus", "oral", "rehydration", "therapy"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0023992", "name": "C0023992#ent", "pos": [13, 14]}}
{"token": ["The", "vinblastine", "induction", "also", "was", "repressed", "by", "C0036079#ent", "<e1>", "treatment", ",", "but", "not", "by", "treatment", "with", "C0021246#ent", "<e2>", ",", "suggesting", "a", "role", "for", "the", "NF", "kappa", "B", "pathway", "in", "the", "inductive", "response"], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [16, 17]}}
{"token": ["The", "nonsteroidal", "antiinflammatory", "drugs", "acetylsalicylic", "acid", "C0036079#ent", "<e1>", "sulfinpyrazone", "and", "C0021246#ent", "<e2>", "were", "tested", "at", "10(-10", ")", "-", "10(-5", ")", "M", "for", "their", "effect", "on", "arrhythmias", "of", "monolayer", "cultures", "neonatal", "rat", "heart", "myocytes"], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [10, 11]}}
{"token": ["The", "T-ALL", "was", "C1867800#ent", "<e1>", "negative", "and", "neither", "the", "C1336596#ent", "<e2>", "nor", "the", "LYL-1", "genes", ",", "both", "situated", "at", "chromosome", "19", "p13", "were", "rearranged", "."], "h": {"id": "C1867800", "name": "C1867800#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [9, 10]}}
{"token": ["We", "here", "report", "an", "alternative", "C1867800#ent", "<e1>", "transcript", ",", "fusing", "exon", "17", "C1336596#ent", "<e2>", "with", "exon", "5", "PBX1", ",", "in", "a", "paediatric", "t(1;19)-positive", "ALL", "."], "h": {"id": "C1867800", "name": "C1867800#ent", "pos": [5, 6]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [12, 13]}}
{"token": ["C0043914#ent", "<e1>", "was", "predominantly", "found", "in", "water", "samples", "while", "C3813144#ent", "<e2>", "and", "END", "were", "detected", "at", "higher", "levels", "in", "the", "suspended", "particle", "."], "h": {"id": "C0043914", "name": "C0043914#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3813144", "name": "C3813144#ent", "pos": [9, 10]}}
{"token": ["The", "prostaglandin", "inhibitors", "C0021246#ent", "<e1>", ",", "meclofenamate", ",", "and", "C1413096#ent", "<e2>", "20", "-", "5720", "similarly", "had", "no", "direct", "effect", "on", "sodium", "transport", "the", "nephron", "segments", "studied", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "our", "results", "suggest", "a", "role", "for", "the", "C1419239#ent", "<e1>", "and", "Xrs2", "proteins", "and", "thereby", "for", "the", "MRX", "complex", "promoting", "C3889721#ent", "<e2>", "via", "both", "the", "Rad5", "and", "Rad52", "pathways"], "h": {"id": "C1419239", "name": "C1419239#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889721", "name": "C3889721#ent", "pos": [22, 23]}}
{"token": ["Our", "studies", "demonstrate", "an", "alternative", "mechanism", "for", "C1663627#ent", "<e1>", "involvement", "in", "the", "genesis", "of", "NHL", "and", "suggest", "that", "C3639960#ent", "<e2>", "activation", "results", "from", "ATIC-mediated", "homodimerization"], "h": {"id": "C1663627", "name": "C1663627#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3639960", "name": "C3639960#ent", "pos": [18, 19]}}
{"token": ["In", "severe", "acute", "pancreatitis", "SAP", ")", ",", "the", "mechanisms", "leading", "to", "adult", "respiratory", "distress", "syndrome", "C0035222#ent", "<e1>", ")", "are", "usually", "attributed", "to", "the", "release", "of", "active", "C3541394#ent", "<e2>", "and", "vasoactive", "substances", "the", "pancreas", "."], "h": {"id": "C0035222", "name": "C0035222#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [26, 27]}}
{"token": ["Methylation", "of", "lysine", "9", "C1416747#ent", "<e1>", ")", "in", "the", "N-terminus", "tail", "of", "C3829685#ent", "<e2>", "H3", ")", "in", "chromatin", "is", "associated", "with", "transcriptionally", "silenced", "genes", "and", "is", "mediated", "by", "histone", "methyltransferases"], "h": {"id": "C1416747", "name": "C1416747#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3829685", "name": "C3829685#ent", "pos": [12, 13]}}
{"token": ["Dynein", "heavy", "chain", "Dhc", ")", ",", "spindle", "(", "spn", ")", "C0017337#ent", "<e1>", "and", "maelstrom", "(", "C1825933#ent", "<e2>", ")", "are", "required", "for", "the", "re-localization", "of", "the", "Bic-D::GFP", "focus", "from", "its", "anterior", "to", "its", "posterior", "oocyte", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1825933", "name": "C1825933#ent", "pos": [15, 16]}}
{"token": ["Northern", "blot", "analysis", "a", "rapidly", "increased", "expression", "of", "the", "bcl-x(s", ")", "C0079429#ent", "<e1>", "without", "any", "change", "in", "the", "expression", "of", "the", "C1704467#ent", "<e2>", "indicating", "that", "HUVECs", "under", "chloroquine", "were", "undergoing", "apoptosis", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [21, 22]}}
{"token": ["Cross-links", "to", "5S", "RNA", "observed", "with", "C3813714#ent", "<e1>", "(", "positions", "34", "-", "41", ")", ",", "and", "C1419635#ent", "<e2>", "(", "precise", "site", "not", "localised", ")", "."], "h": {"id": "C3813714", "name": "C3813714#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419635", "name": "C1419635#ent", "pos": [16, 17]}}
{"token": ["The", "patient", "had", "recently", "been", "started", "on", "a", "trial", "of", "Mesalamine", "(", "C0127615#ent", "<e1>", "5-ASA", ")", "for", "treatment", "of", "her", "C0009324#ent", "<e2>", "months", "ago", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [20, 21]}}
{"token": ["C3887624#ent", "<e1>", "is", "therefore", "a", "true", "C1334706#ent", "<e2>", "that", "may", "be", "involved", "in", "tissue", "injury", "remodeling", "."], "h": {"id": "C3887624", "name": "C3887624#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [6, 7]}}
{"token": ["In", "pBR329", ",", "the", "genes", "providing", "resistance", "to", "ampicillin", "(", "C0005244#ent", "<e1>", ",", "bla", ")", "and", "chloramphenicol", "(", "C1366498#ent", "<e2>", "cat", ")", "are", "encoded", "on", "the", "same", "strand", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366498", "name": "C1366498#ent", "pos": [18, 19]}}
{"token": ["Drug-resistance", "genes", "cloned", "into", "M13", "include", "the", "C0005244#ent", "<e1>", "(", "bla", ")", "gene", "and", "the", "C1366498#ent", "<e2>", "cat", ")", "gene", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366498", "name": "C1366498#ent", "pos": [15, 16]}}
{"token": ["We", "now", "identify", "the", "metalloprotease", "MT1-matrix", "metalloprotease", "MMP", ")", ",", "an", "C1823138#ent", "<e1>", "in", "the", "C1417215#ent", "<e2>", ",", "as", "a", "protease", "that", "processes", "C68", "to", "the", "amyloidogenic", "peptides", "."], "h": {"id": "C1823138", "name": "C1823138#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417215", "name": "C1417215#ent", "pos": [15, 16]}}
{"token": ["To", "evaluate", "the", "efficacy", "of", "C0015821#ent", "<e1>", "as", "a", "treatment", "for", "C0017536#ent", "<e2>"], "h": {"id": "C0015821", "name": "C0015821#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017536", "name": "C0017536#ent", "pos": [11, 12]}}
{"token": ["We", "have", "previously", "shown", "that", "C0009325#ent", "<e1>", "crosslinked", "using", "N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide", "(EDC", "and", "N-hydroxysuccinimide", "(", "C1417725#ent", "<e2>", ")", "supports", "adhesion", "and", "proliferation", "of", "human", "umbilical", "vein", "endothelial", "cells", "HUVECs", ")", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417725", "name": "C1417725#ent", "pos": [14, 15]}}
{"token": ["Metabolism", "by", "aldehyde", "oxidase", "AO", ",", "EC", "1.2.3.1", ")", "was", "the", "major", "catabolic", "route", ",", "yielding", "uridine", "as", "the", "primary", "metabolite", "which", "was", "C0025517#ent", "<e1>", "further", "to", "uracil", "by", "C1421363#ent", "<e2>"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1421363", "name": "C1421363#ent", "pos": [29, 30]}}
{"token": ["In", "the", "sagittal", "type", "split", "lines", "aligned", "in", "parallel", "to", "the", "lateral", "border", "at", "right", "angles", "the", "C2347743#ent", "<e1>", "of", "the", "tip", "and", "medial", "border", "of", "the", "C4283801#ent", "<e2>", "."], "h": {"id": "C2347743", "name": "C2347743#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [27, 28]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "determine", "whether", "genetically", "determined", "C0065661#ent", "<e1>", "deficiency", "is", "associated", "with", "susceptibility", "to", "C3495559#ent", "<e2>", "JRA", ")", "and", "whether", "MBL2", "genotypes", "are", "associated", "with", "JRA", "severity", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "C1310463#ent", "<e1>", "mutants", "on", "protease", "function", "interdomain", "interactions", "within", "C1705392#ent", "<e2>", "."], "h": {"id": "C1310463", "name": "C1310463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705392", "name": "C1705392#ent", "pos": [12, 13]}}
{"token": ["Total", "cellular", "activities", "carnitine", ":", "palmitoyl-CoA", "transferase", "crotonase", ",", "C0085889#ent", "<e1>", "3-keto-acyl-CoA", "thiolase", ",", "citrate", "synthase", "NADH", ":", "C0311584#ent", "<e2>", "succinate", ":", "C0311584#ent", "<e2>", "and", "cytochrome", "c", "oxidase", "measured", "in", "contralateral", "and", "stimulated", "muscles", "at", "various", "times", "."], "h": {"id": "C0085889", "name": "C0085889#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0311584", "name": "C0311584#ent", "pos": [18, 19]}}
{"token": ["C0076688#ent", "<e1>", "ahd", "neither", "an", "C0003286#ent", "<e2>", "30", "mg/kg", "p.o", "."], "h": {"id": "C0076688", "name": "C0076688#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [5, 6]}}
{"token": ["IRS-1", "association", "with", "Grb2", "and", "C1705325#ent", "<e1>", "which", "link", "C1334088#ent", "<e2>", "to", "the", "Ras-MAPK", "and", "PI3K-Akt", "pathways", ",", "respectively", ",", "was", "enhanced", "in", "both", "cell", "types", "the", "presence", "of", "EN", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334088", "name": "C1334088#ent", "pos": [9, 10]}}
{"token": ["Similar", "titrations", "with", "magnesium", "or", "strontium", "demonstrate", "that", "the", "metal", "binding", "site", "C0010646#ent", "<e1>", "exhibits", "specificity", "for", "C2936886#ent", "<e2>", "or", "terbium", "."], "h": {"id": "C0010646", "name": "C0010646#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [17, 18]}}
{"token": ["The", "C1334324#ent", "<e1>", "currently", "composed", "of", "three", "members", ",", "C0012524#ent", "<e2>", "and", "two", "tyrosinase-related", "proteins", "TRP-1", "and", "TRP-2", "."], "h": {"id": "C1334324", "name": "C1334324#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012524", "name": "C0012524#ent", "pos": [9, 10]}}
{"token": ["The", "first", "is", "the", "C1334324#ent", "<e1>", "which", "is", "comprised", "of", "C0012524#ent", "<e2>", "(", "c", "locus", ",", "gp75", "(", "b", "locus", ")", "and", "DOPAchrome", "tautomerase", "slt", "locus", ")", "."], "h": {"id": "C1334324", "name": "C1334324#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012524", "name": "C0012524#ent", "pos": [10, 11]}}
{"token": ["We", "have", "investigated", "whether", "restoration", "of", "the", "balance", "between", "neutrophil", "elastase", "its", "inhibitor", ",", "alpha(1)-antitrypsin", ",", "can", "prevent", "the", "progression", "of", "C0034067#ent", "<e1>", "patients", "with", "C0221757#ent", "<e2>"], "h": {"id": "C0034067", "name": "C0034067#ent", "pos": [21, 22]}, "relation": "related_to", "t": {"id": "C0221757", "name": "C0221757#ent", "pos": [25, 26]}}
{"token": ["In", "two", "brothers", "treated", "for", "severe", "C0034067#ent", "<e1>", "was", "demonstrated", "an", "C0221757#ent", "<e2>", "associated", "with", "ZZ", "phenotype", "(", "Pi", "system", "."], "h": {"id": "C0034067", "name": "C0034067#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0221757", "name": "C0221757#ent", "pos": [11, 12]}}
{"token": ["We", "also", "assessed", "the", "effect", "of", "C0812246#ent", "<e1>", ",", "wortmannin", ",", "a", "C1705325#ent", "<e2>", "and", "cAMP-dependent", "protein", "kinase", "inhibitor", "Sp1", "accumulation", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705325", "name": "C1705325#ent", "pos": [12, 13]}}
{"token": ["Pretreatment", "with", "C0033497#ent", "<e1>", ",", "an", "inhibitor", "of", "P450", "isozymes", "to", "the", "C3814396#ent", "<e2>", "decreased", "TIQ", "4-hydroxylase", "activity", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3814396", "name": "C3814396#ent", "pos": [12, 13]}}
{"token": ["CA", "and", "UDCA", "repressed", "Cyp7a1", "in", "FXR(+/+", ")", "mice", "and", "to", "lesser", "extents", "FXR(-/-", ")", "mice", "and", "induced", "Cyp3a11", "and", "C0070319#ent", "<e1>", "independent", "of", "C1417825#ent", "<e2>", "."], "h": {"id": "C0070319", "name": "C0070319#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1417825", "name": "C1417825#ent", "pos": [24, 25]}}
{"token": ["In", "a", "randomised", "study", ",", "242", "patients", "who", "were", "experiencing", "C0520909#ent", "<e1>", "received", "C0209210#ent", "<e2>", "and", "placebo", ",", "haloperidol", "and", "placebo", ",", "C0209210#ent", "<e2>", "and", "dexamethasone", ",", "or", "haloperidol", "and", "dexamethasone", "."], "h": {"id": "C0520909", "name": "C0520909#ent", "pos": [10, 11]}, "relation": "may_be_prevented_by", "t": {"id": "C0209210", "name": "C0209210#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "evaluate", "whether", "an", "inspired", "oxygen", "fraction", "0.8", "decreases", "C0520909#ent", "<e1>", "in", "patients", "receiving", "the", "5-HT3-antagonist", "C0209210#ent", "<e2>", "."], "h": {"id": "C0520909", "name": "C0520909#ent", "pos": [15, 16]}, "relation": "may_be_prevented_by", "t": {"id": "C0209210", "name": "C0209210#ent", "pos": [22, 23]}}
{"token": ["Among", "199,642", "newborns", ",", "nine", "cases", "with", "classic", "galactosaemia", "three", "with", "C0751161#ent", "<e1>", "six", "with", "compound", "Duarte2/heterozygotes", "for", "C0016952#ent", "<e2>", "and", "four", "with", "compound2", "Duarte", "homozygosity", "found", "."], "h": {"id": "C0751161", "name": "C0751161#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [18, 19]}}
{"token": ["In", "other", "groups", ",", "C0011501#ent", "<e1>", ",", "norepinephrine", "(", "NE", ")", ",", "C0027679#ent", "<e2>", "(", "NEO", ")", "and", "saline", "were", "intracerebroventricularly", "(", "i.c.v", ".", ")"], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027679", "name": "C0027679#ent", "pos": [12, 13]}}
{"token": ["Cell", "culture", "studies", "that", "wild-type", "but", "not", "mutant", "C1420389#ent", "<e1>", "spectrin", "stabilizes", "C1705290#ent", "<e2>", "at", "the", "plasma", "membrane"], "h": {"id": "C1420389", "name": "C1420389#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705290", "name": "C1705290#ent", "pos": [12, 13]}}
{"token": ["The", "expression", "status", "C1421397#ent", "<e1>", ",", "POU2F3", ",", "TRIM29", ",", "and", "another", "proposed", "C1332010#ent", "<e2>", "that", "is", "telomeric", "to", "the", "region", "(", "BCSC1", ")", "also", "was", "examined", "."], "h": {"id": "C1421397", "name": "C1421397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332010", "name": "C1332010#ent", "pos": [13, 14]}}
{"token": ["C2987634#ent", "<e1>", "acting", "at", "5-HT3", "receptors", "C0031404#ent", "<e2>", "and", "2-methyl-5-HT", ")", "had", "no", "effect", "catalepsy", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031404", "name": "C0031404#ent", "pos": [6, 7]}}
{"token": ["The", "C0812325#ent", "<e1>", "was", "found", "to", "be", "accompanied", "by", "C0669365#ent", "<e2>", "changes", "in", "the", "DNA", "binding", "of", "the", "ubiquitous", "transcription", "factor", "Sp1", ",", "characteristic", "of", "an", "exposure", "to", "."], "h": {"id": "C0812325", "name": "C0812325#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [9, 10]}}
{"token": ["Bovine", "lymphocytes", "infected", "with", "the", "parasite", "Theileria", "parva", "secrete", "a", "C0812325#ent", "<e1>", "is", "essential", "for", "their", "proliferation", "in", "vitro", "also", "C0669365#ent", "<e2>", "express", "interleukin", "2", "receptors", "their", "surface", "."], "h": {"id": "C0812325", "name": "C0812325#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [20, 21]}}
{"token": ["gamma-Glutamyl", "hydrolase", "GH", ",", "EC", "3.4.19.9", ")", "is", "a", "lysosomal", "and", "secreted", "glycoprotein", "that", "hydrolyzes", "the", "C1415051#ent", "<e1>", "antifolate", "and", "folate", "C0392213#ent", "<e2>", "."], "h": {"id": "C1415051", "name": "C1415051#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0392213", "name": "C0392213#ent", "pos": [21, 22]}}
{"token": ["Expression", "of", "type", "II", "collagen", "matrilin-1", ",", "PAPS", "C0023689#ent", "<e1>", ",", "and", "CA-II", "was", "regulated", "by", "extracellular", "signal-regulated", "protein", "kinase", "protein", "kinase", "C", "and", "C0257535#ent", "<e2>", "signaling", "molecules", "to", "regulate", "chondrogenesis", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [24, 25]}}
{"token": ["Retinal", "pigment", "epithelium", "C1419621#ent", "<e1>", ")", "was", "isolated", "from", "human", "donors", "with", "no", "known", "C0015397#ent", "<e2>", "normal-appearing", "fundi", "and", "was", "grown", "in", "culture", "."], "h": {"id": "C1419621", "name": "C1419621#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [14, 15]}}
{"token": ["Of", "the", "21", "patients", ",", "18", "(", "86", "%", ")", "had", "received", "inhaled", "C0030863#ent", "<e1>", "as", "prophylaxis", "against", "C1535939#ent", "<e2>"], "h": {"id": "C0030863", "name": "C0030863#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [18, 19]}}
{"token": ["The", "efficacy", "and", "toxicity", "of", "C0030863#ent", "<e1>", "inhaled", "once", "a", "month", "to", "prevent", "C1535939#ent", "<e2>", "PCP", ")", "was", "investigated", "in", "102", "patients", "with", "the", "acquired", "immunodeficiency", "syndrome", "AIDS", ")", "or", "AIDS-related", "complex", "ARC", ")", "."], "h": {"id": "C0030863", "name": "C0030863#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [13, 14]}}
{"token": ["Carbadox", "(", "CBX", ")", ",", "an", "antibacterial", "agent", "and", "C0034238#ent", "<e1>", "PT", ")", ",", "an", "C0003158#ent", "<e2>", ",", "are", "formulated", "either", "separately", "or", "together", "in", "swine", "feeds", "."], "h": {"id": "C0034238", "name": "C0034238#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003158", "name": "C0003158#ent", "pos": [15, 16]}}
{"token": ["C0027877#ent", "<e1>", "considered", "to", "cause", "several", "serious", "complications", ",", "including", "progressive", "C0034069#ent", "<e2>", "to", "death", "in", "the", "fourth", "or", "fifth", "decades", "."], "h": {"id": "C0027877", "name": "C0027877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [11, 12]}}
{"token": ["On", "the", "tenth", "post", "partum", ",", "C0008031#ent", "<e1>", "chest", "X-ray", "in", "favour", "of", "C0740766#ent", "<e2>", "left", "inferior", "lobe"], "h": {"id": "C0008031", "name": "C0008031#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0740766", "name": "C0740766#ent", "pos": [13, 14]}}
{"token": ["An", "excess", "of", "C1335267#ent", "<e1>", "Pr3", ")", "is", "an", "assumed", "risk", "factor", "elastin", "loss", "C0024117#ent", "<e2>"], "h": {"id": "C1335267", "name": "C1335267#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [14, 15]}}
{"token": ["Twelve", "cases", "of", "diabetes", "mellitus", "C0030864#ent", "<e1>", "Lomidine", ")", "treatment", "for", "antimonial", "-resistant", "cases", "of", "C0023290#ent", "<e2>", "are", "reported", "."], "h": {"id": "C0030864", "name": "C0030864#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [15, 16]}}
{"token": ["Conflicting", "data", "exist", "regarding", "the", "role", "of", "the", "interferon", "(IFN)-gamma-producing", "C3540579#ent", "<e1>", "CD4(+", ")", "T-cell", "subset", "and", "C1825592#ent", "<e2>", "in", "IPS", "."], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1825592", "name": "C1825592#ent", "pos": [17, 18]}}
{"token": ["The", "results", "suggest", "that", "some", "C0010656#ent", "<e1>", "may", "have", "evolved", "as", "autonomous", "modules", "and", "become", "C1418370#ent", "<e2>", "cysteine", "proteinases"], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418370", "name": "C1418370#ent", "pos": [15, 16]}}
{"token": ["Although", "C0162745#ent", "<e1>", "can", "be", "helpful", "in", "the", "treatment", "of", "decubitus", "ulcers", "C0057621#ent", "<e2>", "is", "significantly", "better", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0057621", "name": "C0057621#ent", "pos": [12, 13]}}
{"token": ["C0600327#ent", "<e1>", "TSST", ")", "are", "23", "-", "30", "kD", "C0086376#ent", "<e2>", "that", "have", "been", "isolated", "from", "incubation", "media", "of", "strains", "of", "Staphylococcus", "aureus", "cultured", "from", "patients", "with", "toxic", "shock", "syndrome", "TSS", ")", "."], "h": {"id": "C0600327", "name": "C0600327#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["ATP", "and", "UTP", "activated", "Gq/11", "and", "Gi3", "in", "gastric", "and", "aortic", "smooth", "muscle", "heart", "membranes", "Gq/11", "and", "Gi1", "and/or", "C1825938#ent", "<e1>", "in", "liver", "membranes", "and", "C1822658#ent", "<e2>", "and", "Gi1", "-", "3", "in", "brain", "membranes"], "h": {"id": "C1825938", "name": "C1825938#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1822658", "name": "C1822658#ent", "pos": [25, 26]}}
{"token": ["C0756044#ent", "<e1>", "has", "both", "local", "anesthetic", "and", "partial", "mu-opioid", "receptor", "C0243192#ent", "<e2>", "properties", "."], "h": {"id": "C0756044", "name": "C0756044#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}}
{"token": ["Mf", "at", "the", "hprt", "locus", "C1705270#ent", "<e1>", "was", "determined", "by", "limiting", "dilution", "assay", "C0039902#ent", "<e2>", "(", "6-TG", ")", "."], "h": {"id": "C1705270", "name": "C1705270#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [13, 14]}}
{"token": ["C0014027#ent", "<e1>", "treatment", "caused", "a", "further", "reduction", "in", "C2362049#ent", "<e2>", "excretion", "and", "an", "increase", "in", "serum", "albumin", "concentration", "in", "nephrotic", "rats", "fed", "8.5", "%", "protein", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2362049", "name": "C2362049#ent", "pos": [8, 9]}}
{"token": ["The", "investigators", "concluded", "that", "blood", "pressure", "similar", "in", "both", "groups", "but", "only", "C0014027#ent", "<e1>", "had", "a", "significant", "effect", "to", "sustain", "decreased", "C2362049#ent", "<e2>", "excretion", "for", "a", "5-year", "follow-up", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2362049", "name": "C2362049#ent", "pos": [21, 22]}}
{"token": ["Conduction", "defects", "were", "observed", "in", "26", "p.", "100", "of", "cases", "with", "C0018801#ent", "<e1>", "55", "p.", "100", "of", "which", "had", "C1260873#ent", "<e2>"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1260873", "name": "C1260873#ent", "pos": [19, 20]}}
{"token": ["C0040558#ent", "<e1>", "may", "respond", "to", "other", "antimicrobials", ",", "including", "macrolide", "antibiotics", "C0010980#ent", "<e2>", ",", "clinidamycin", ",", "and", "atovaquone", "."], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [11, 12]}}
{"token": ["C1419212#ent", "<e1>", "is", "able", "to", "remove", "both", "C1415287#ent", "<e2>", "and", "GluR2", "AMPA", "receptor", "subunits", ",", "leading", "to", "C1415287#ent", "<e2>", "dephosphorylation", "."], "h": {"id": "C1419212", "name": "C1419212#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415287", "name": "C1415287#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "provide", "evidence", "for", "C3273763#ent", "<e1>", "reciprocal", "regulation", "of", "transcripts", "of", "C1823185#ent", "<e2>", "vascular", "endothelium"], "h": {"id": "C3273763", "name": "C3273763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1823185", "name": "C1823185#ent", "pos": [12, 13]}}
{"token": ["C0007787#ent", "<e1>", "induced", "for", "10", "min", ",", "and", "C0030883#ent", "<e2>", "(", "40", "mg/kg", ")", "was", "administered", "intraperitoneally", "30", "min", "before", "ischemia", "."], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [8, 9]}}
{"token": ["Treatment", "with", "C1412304#ent", "<e1>", "and", "especially", "with", "PGJ2", "enhanced", "the", "synthesis", "of", "C1415760#ent", "<e2>", "in", "all", "these", "cells", "."], "h": {"id": "C1412304", "name": "C1412304#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [12, 13]}}
{"token": ["C1412304#ent", "<e1>", "and", "delta", "12-PGJ2", "were", "found", "to", "induce", "C1415760#ent", "<e2>", "synthesis", "in", "uninfected", "or", "VSV-infected", "HeLa", "cells"], "h": {"id": "C1412304", "name": "C1412304#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [9, 10]}}
{"token": ["A", "53", "year", "old", "Chinese", "man", "with", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e1>", ")", "had", "an", "isolated", "12th", "nerve", "palsy", "C0740766#ent", "<e2>"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0740766", "name": "C0740766#ent", "pos": [19, 20]}}
{"token": ["C1706005#ent", "<e1>", "binding", "to", "LEH", "was", "inhibited", "by", "phosphocholine", "and", "C1705556#ent", "<e2>", ",", "but", "not", "by", "choline", "chloride"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["Diagnoses", "in", "the", "patients", "included", "gout", "in", "seven", ";", "C1527336#ent", "<e1>", "two", ";", "medullary", "sponge", "kidney", "two", ";", "primary", "aldosteronism", "two", ";", "and", "C0023374#ent", "<e2>", "hyperparathyroidism", ",", "glycogen", "storage", "disease", "type", "XI", "Wilson", "disease", "and", "pseudo-Bartter", "syndrome", "one", "each", "."], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [23, 24]}}
{"token": ["There", "was", "no", "significant", "correlation", "between", "C1366480#ent", "<e1>", "content", "and", "other", "parameters", ",", "including", "estrogen", "receptor", "C1366500#ent", "<e2>", "DNA", "ploidy", "S", "phase", "or", "Scarff-Bloom-Richardson", "score"], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366500", "name": "C1366500#ent", "pos": [16, 17]}}
{"token": ["When", "reconstituted", "with", "spinach", "ferredoxin", "spinach", "ferredoxin", "NADP+", "oxidoreductase", "purified", "C0608437#ent", "<e1>", "catalyzed", "the", "C1312754#ent", "<e2>", "the", "xenobiotic", "substrates", "precocene", "II", "7-ethoxycoumarin", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1312754", "name": "C1312754#ent", "pos": [14, 15]}}
{"token": ["Unexpectedly", ",", "however", ",", "adenovirus-mediated", "Gli-1", "overexpression", "blocked", "the", "Ihh", "enhancement", "of", "both", "C1618608#ent", "<e1>", "localization", "on", "the", "plasma", "membrane", "C0566602#ent", "<e2>", "migration", "."], "h": {"id": "C1618608", "name": "C1618608#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "antisense", "experiments", "the", "critical", "importance", "of", "C1415194#ent", "<e1>", "in", "mediating", "C0534628#ent", "<e2>", "activities", "."], "h": {"id": "C1415194", "name": "C1415194#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0534628", "name": "C0534628#ent", "pos": [12, 13]}}
{"token": ["The", "role", "of", "sympathetic", "tone", "the", "haemodynamic", "response", "C0022251#ent", "<e1>", "dinitrate", "was", "examined", "using", "rats", "pretreated", "with", "the", "C0085648#ent", "<e2>", "hexamethonium", "."], "h": {"id": "C0022251", "name": "C0022251#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "treatment", "with", "U73122", "but", "not", "U73343", "blocked", "the", "GTP-induced", "inhibition", "of", "C0001492#ent", "<e1>", "indicating", "blockade", "at", "the", "level", "of", "C1257883#ent", "<e2>"], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1257883", "name": "C1257883#ent", "pos": [21, 22]}}
{"token": ["The", "ability", "of", "the", "cloned", "C5a", "receptor", "inhibit", "C0001492#ent", "<e1>", "to", "stimulate", "phospholipase", "C", "C1257883#ent", "<e2>", "examined", "in", "transfected", "cells", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1257883", "name": "C1257883#ent", "pos": [14, 15]}}
{"token": ["They", "were", ",", "C0018081#ent", "<e1>", ",", "syphilis", ",", "nongonococcal", "urethritis", "NGU", ")", ",", "and", "C0281779#ent", "<e2>"], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0281779", "name": "C0281779#ent", "pos": [14, 15]}}
{"token": ["C0018081#ent", "<e1>", "is", "the", "most", "common", "STD", "co-existing", "with", "NGU", ",", "C0281779#ent", "<e2>", "even", "syphilis", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0281779", "name": "C0281779#ent", "pos": [11, 12]}}
{"token": ["We", "show", "that", "forskolin", "and", "8-bromo-cAMP", "block", "basic", "Fibroblast", "Growth", "Factor-induced", "DNA", "synthesis", "do", "not", "inhibit", "mitogen", "activated", "C0033640#ent", "<e1>", "whereas", "they", "reduce", "G1", "cyclin", "E", "and", "C3889128#ent", "<e2>", ")", "expression", "without", "modification", "of", "cyclin", "A", "level", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [27, 28]}}
{"token": ["To", "assess", "the", "efficacy", "of", "C0072916#ent", "<e1>", "relieving", "symptoms", "of", "functional", "C0013395#ent", "<e2>", "."], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [11, 12]}}
{"token": ["Gastric", "histology", "did", "not", "influence", "the", "effect", "of", "C0072916#ent", "<e1>", "on", "the", "symptoms", "of", "functional", "C0013395#ent", "<e2>", "."], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "C0072916#ent", "<e1>", "stimulates", "antral", "motility", "decreases", "biliary", "reflux", "patients", "with", "C0013395#ent", "<e2>", "and", "increased", "duodenogastric", "reflux"], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [13, 14]}}
{"token": ["The", "interaction", "of", "C1425471#ent", "<e1>", "with", "c-Crk", "and", "C0812253#ent", "<e2>", "was", "studied", "in", "more", "detail", "."], "h": {"id": "C1425471", "name": "C1425471#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812253", "name": "C0812253#ent", "pos": [8, 9]}}
{"token": ["We", "have", "shown", "that", "intestinal", "epithelial", "cells", "abundant", "C0669365#ent", "<e1>", "levels", "of", "the", "C0007428#ent", "<e2>", "to", "function", "in", "HLA", "class", "II", "antigen", "presentation", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [13, 14]}}
{"token": ["5-HT2B", "receptor", "activation", "also", "increases", "activity", "of", "the", "Src", "family", "kinase", "C0080298#ent", "<e1>", ",", "Fyn", ",", "and", "C1710701#ent", "<e2>", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1710701", "name": "C1710701#ent", "pos": [17, 18]}}
{"token": ["In", "most", "plants", ",", "plastidial", "C0064566#ent", "<e1>", "is", "a", "multisubunit", "complex", "comprised", "of", "four", "C1305923#ent", "<e2>", ",", "which", "catalyse", "two", "reactions", "."], "h": {"id": "C0064566", "name": "C0064566#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}}
{"token": ["The", "observed", "venular", "constriction", "be", "blocked", "by", "low", "concentrations", "(", "10(-9", ")", "M", ")", "of", "prazosin", "or", "C0012373#ent", "<e1>", "and", "by", "high", "concentrations", ">", "10(-6", ")", "M", ")", "of", "C0242546#ent", "<e2>", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0242546", "name": "C0242546#ent", "pos": [29, 30]}}
{"token": ["Both", "araU", "derivatives", "applied", "as", "0.1", "%", "eyedrops", "suppressed", "the", "development", "of", "C0022568#ent", "<e1>", "as", "monitored", "by", "the", "reduced", "number", "of", "C0015230#ent", "<e2>"], "h": {"id": "C0022568", "name": "C0022568#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [21, 22]}}
{"token": ["In", "hyperlipidemics", ",", "a", "reduction", "of", "triglyceride", "levels", "was", "particularly", "evident", ";", "however", ",", "in", "mixed", "types", "of", "C0020473#ent", "<e1>", ",", "a", "significant", "C0151718#ent", "<e2>", "also", "demonstrated", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0151718", "name": "C0151718#ent", "pos": [23, 24]}}
{"token": ["Tailoring", "of", "antilipid", "therapy", "in", "selected", "hyperuricemic", "and", "C0020473#ent", "<e1>", "patients", "with", "fenofibrate", "may", "be", "of", "benefit", "in", "C0151718#ent", "<e2>", "uric", "acid", "levels", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0151718", "name": "C0151718#ent", "pos": [18, 19]}}
{"token": ["MMPs", "are", "closely", "modulated", "by", "their", "activators", ",", "membrane", "type-MMP", "(", "C1568288#ent", "<e1>", ")", "and", "their", "endogenous", "inhibitors", ",", "the", "tissue", "inhibitors", "C1334706#ent", "<e2>", "(", "TIMPs", ")", "."], "h": {"id": "C1568288", "name": "C1568288#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [22, 23]}}
{"token": ["The", "C1568288#ent", "<e1>", "also", "exhibit", "differential", "inhibition", "by", "members", "of", "the", "tissue", "inhibitor", "C1334706#ent", "<e2>", "(", "TIMP", ")", "family", "."], "h": {"id": "C1568288", "name": "C1568288#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [13, 14]}}
{"token": ["Our", "data", "also", "show", "by", "sequential", "in", "vitro", "assays", "that", "TNF-alpha", "enhances", "C1825781#ent", "<e1>", "phosphorylation", "of", "Raf-1", "on", "threonine", ",", "enhancing", "C0139030#ent", "<e2>", "toward", "MAP", "kinase", "kinase"], "h": {"id": "C1825781", "name": "C1825781#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0139030", "name": "C0139030#ent", "pos": [21, 22]}}
{"token": ["We", "have", "compared", "the", "normal", "C1335654#ent", "<e1>", "to", "AML1/MDS1", ",", "AML1/EAP", "and", "C1838720#ent", "<e2>", "as", "transcriptional", "regulators", "the", "CSF1R", "promoter", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [5, 6]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1838720", "name": "C1838720#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "that", "expression", "of", "AML1/EAP", "and", "C1838720#ent", "<e1>", "can", "interfere", "with", "normal", "C1335654#ent", "<e2>", "function", ",", "and", "that", "C1838720#ent", "<e1>", "has", "tumor-promoting", "properties", "in", "an", "embryonic", "rat", "fibroblast", "cell", "line"], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [14, 15]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1838720", "name": "C1838720#ent", "pos": [8, 9]}}
{"token": ["Concomitant", "antacids", ",", "calcium", "antagonists", "beta-blockers", "and", "C0020592#ent", "<e1>", "did", "not", "affect", "the", "results", ",", "but", "concomitant", "C0080151#ent", "<e2>", "reduced", "the", "mean", "improvement", "rate", "by", "14", "%", "(", "p", "<", "0.01", ")", "."], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [17, 18]}}
{"token": ["After", "C1334887#ent", "<e1>", "injection", ",", "increased", "C0087140#ent", "<e2>", "expression", "was", "observed", "in", "a", "wide", "range", "of", "locations", "in", "hypothalamus", ",", "brainstem", ",", "and", "spinal", "cord"], "h": {"id": "C1334887", "name": "C1334887#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [6, 7]}}
{"token": ["The", "present", "knowledge", "of", "CQ", "kinetics", "could", "provide", "a", "basis", "for", "revision", "of", "current", "dosage", "regimens", "in", "C0024530#ent", "<e1>", "suppression", "and", "C0003873#ent", "<e2>", "ensure", "efficacious", "and", "safe", "therapy", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}}
{"token": ["A", "severe", "flare-up", "of", "chronic", "hepatitis", "B", "infection", "liver", "cell", "insufficiency", "been", "observed", "in", "two", "patients", "after", "discontinuation", "of", "chloroquine", "administered", "either", "as", "C0024530#ent", "<e1>", "prophylaxis", "or", "as", "treatment", "of", "presumed", "C0003873#ent", "<e2>"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [31, 32]}}
{"token": ["The", "observed", "release", "of", "PAF", "was", "not", "a", "direct", "consequence", "of", "the", "C0004623#ent", "<e1>", "because", "it", "was", "minimal", "or", "absent", "in", "patients", "with", "C0038395#ent", "<e2>", "glomerular", "involvement", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0038395", "name": "C0038395#ent", "pos": [23, 24]}}
{"token": ["C1387532#ent", "<e1>", "to", "deficiency", "of", "C0340968#ent", "<e2>", "a", "rare", "autosomal", "recessive", "disorder"], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0340968", "name": "C0340968#ent", "pos": [5, 6]}}
{"token": ["That", "only", "5", "of", "13", "children", "had", "severe", "chronic", "evolutive", "C1387532#ent", "<e1>", "that", "the", "poor", "prognosis", "neonatal", "haemolytic", "jaundice", "to", "C0340968#ent", "<e2>", "be", "reconsidered", "."], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0340968", "name": "C0340968#ent", "pos": [20, 21]}}
{"token": ["Severe", "C1387532#ent", "<e1>", "Basenji", "dogs", "secondary", "to", "C0340968#ent", "<e2>", "be", "corrected", "by", "allogeneic", "hematopoietic", "cell", "transplantation", "HCT", ")", "from", "littermates", "with", "normal", "hematopoiesis", "after", "conventional", "myeloablative", "or", "nonmyeloablative", "conditioning", "regimens", "."], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0340968", "name": "C0340968#ent", "pos": [7, 8]}}
{"token": ["The", "safety", "and", "pharmacodynamic", "compatibility", "clopidogrel", "with", "medications", "commonly", "used", "in", "patients", "with", "atherosclerosis", ",", "such", "as", ",", "a", "C0001644#ent", "<e1>", "atenolol", ")", "and", "a", "calcium", "uptake", "inhibitor", "C0028066#ent", "<e2>", ")", "were", "assessed", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [28, 29]}}
{"token": ["When", "neuronal", "uptake", "of", "noradrenaline", "was", "blocked", "with", "cocaine", "or", "C0001644#ent", "<e1>", "were", "blocked", "with", "propranolol", ",", "the", "inhibitory", "effect", "of", "C0028066#ent", "<e2>", "against", "noradrenaline-induced", "contractions", "was", "revealed", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [21, 22]}}
{"token": ["Labetalol", ",", "a", "combined", "alpha-", "and", "C0001644#ent", "<e1>", "was", "compared", "with", "C0028066#ent", "<e2>", "in", "a", "placebo-controlled", ",", "randomized", "double-blind", "cross", "over", "study", "four", "week", "treatment", "periods", ")", "of", "11", "normotensive", "patients", "with", "stable", "exertional", "angina", "pectoris"], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [11, 12]}}
{"token": ["Polymorphisms", "in", "both", "C1415455#ent", "<e1>", "and", "11-HSD1", "were", "originally", "identified", "in", "patients", "with", "apparent", "C3551716#ent", "<e2>", "who", "have", "signs", "of", "hyperandrogenism", "and", "decreased", "urinary", "excretion", "cortisol", "versus", "cortisone", "metabolites", ")", "."], "h": {"id": "C1415455", "name": "C1415455#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3551716", "name": "C3551716#ent", "pos": [14, 15]}}
{"token": ["N", "omega-nitro-L-arginine", "methyl", "ester", "L-NAME", ")", "(", "80", "mg", ")", ",", "a", "C0132555#ent", "<e1>", "completely", "abolished", "noradrenaline", "(NA)-induced", "increase", "in", "blood", "flow", "brown", "adipose", "tissue", "C1412726#ent", "<e2>", ")", "in", "the", "urethan-anesthetized", "rat", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [25, 26]}}
{"token": ["Growth", "velocity", "measurements", "were", "assessed", "in", "12", "children", "with", "steroid", "responsive", "but", "frequent", "relapsing", "or", "dependent", "C0027726#ent", "<e1>", "to", "and", "following", "treatment", "with", "either", "C0010583#ent", "<e2>", "or", "chlorambucil", "and", "alternate", "day", "prednisone", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [24, 25]}}
{"token": ["We", "present", "a", "patient", "with", "a", "history", "of", "C0027726#ent", "<e1>", "by", "membranous", "nephropathy", "who", "received", "steroids", "and", "C0010583#ent", "<e2>", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [17, 18]}}
{"token": ["Expression", "of", "a", "C0206526#ent", "<e1>", "Aurora", "A", "mutant", "reverts", "this", "phenotype", ",", "demonstrating", "that", "C0971285#ent", "<e2>", "A", "kinase", "activity", "required", "for", "spindle", "bipolarity", "human", "cells"], "h": {"id": "C0206526", "name": "C0206526#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0971285", "name": "C0971285#ent", "pos": [14, 15]}}
{"token": ["The", "most", "commonly", "reported", "C2963170#ent", "<e1>", "the", "children", "were", "a", "history", "of", "C0006277#ent", "<e2>", ",", "asthma", ",", "skin", "allergies", "pneumonia", ",", "and", "hay", "fever"], "h": {"id": "C2963170", "name": "C2963170#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006277", "name": "C0006277#ent", "pos": [12, 13]}}
{"token": ["The", "positive", "rate", "Chlamydia", "trachomatis", "the", "urethra", "based", "on", "cell", "cultures", "29.0", "%", ",", "(", "30.5", "%", "for", "urethritis", ",", "27.8", "%", "for", "C0014534#ent", "<e1>", ",", "and", "21.1", "%", "for", "C0033581#ent", "<e2>", ")", "."], "h": {"id": "C0014534", "name": "C0014534#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [30, 31]}}
{"token": ["All", "patients", "had", "positive", "urethral", "swab", "six", "women", "had", "chlamydial", "cervicitis", ",", "one", "man", "had", "Reiter's", "syndrome", "one", "man", "C0014534#ent", "<e1>", ",", "and", "five", "men", "C0033581#ent", "<e2>", "."], "h": {"id": "C0014534", "name": "C0014534#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [25, 26]}}
{"token": ["The", "rarity", "of", "amyloidosis", "secondary", "to", "C0036421#ent", "<e1>", "is", "unlikely", "to", "be", "related", "to", "an", "intrinsic", "defect", "C1419798#ent", "<e2>", "production", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419798", "name": "C1419798#ent", "pos": [17, 18]}}
{"token": ["It", "has", "recently", "been", "suggested", "that", "C0812234#ent", "<e1>", "plays", "an", "important", "role", "in", "the", "enhancement", "of", "the", "C1413043#ent", "<e2>", "+", "sensitization", "of", "smooth", "muscle", "contraction"], "h": {"id": "C0812234", "name": "C0812234#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [17, 18]}}
{"token": ["Taken", "together", ",", "it", "seems", "that", "C1567665#ent", "<e1>", "is", "a", "member", "of", "a", "new", "family", "of", "intracellular", "C0031727#ent", "<e2>", "that", "includes", "BPK", ",", "TECI", ",", "and", "TECII", "."], "h": {"id": "C1567665", "name": "C1567665#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["In", "Rh30", "cells", ",", "C1417014#ent", "<e1>", "was", "found", "to", "physically", "interact", "with", "C0289121#ent", "<e2>", "PP5", ")", ",", "previously", "identified", "as", "a", "negative", "regulator", "of", "C1417014#ent", "<e1>", "."], "h": {"id": "C1417014", "name": "C1417014#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0289121", "name": "C0289121#ent", "pos": [12, 13]}}
{"token": ["This", "increased", "resting", "tension", "not", "be", "inhibited", "or", "attenuated", "by", "specific", "adrenergic", ",", "cholinergic", ",", "C0162816#ent", "<e1>", ",", "serotoninergic", "or", "C0085387#ent", "<e2>"], "h": {"id": "C0162816", "name": "C0162816#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [20, 21]}}
{"token": ["Cholinergic", ",", "alpha", "and", "beta", "adrenergic", "C0162816#ent", "<e1>", "(", "H1", "and", "H2", ")", "and", "C0085387#ent", "<e2>", "not", "alter", "the", "action", "of", "bPTH-(1", "-", "34", ")", "."], "h": {"id": "C0162816", "name": "C0162816#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "first", "investigated", "the", "ability", "of", "GNST", "to", "modulate", "metabolizing", "C0014442#ent", "<e1>", "in", "male", "Swiss", "Albino", "C3890230#ent", "<e2>", "injected", "by", "gavage", "(", "24", "mg/kg", "or", "48", "mg/kg", "b.w", ".", ")"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3890230", "name": "C3890230#ent", "pos": [18, 19]}}
{"token": ["Fusion", "ferritin", ",", "combined", "by", "C1414833#ent", "<e1>", "21", "kDa", ")", "and", "C1414852#ent", "<e2>", "19", "kDa", ")", ",", "was", "expressed", "in", "recombinant", "E.", "coli"], "h": {"id": "C1414833", "name": "C1414833#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414852", "name": "C1414852#ent", "pos": [11, 12]}}
{"token": ["The", "C0012634#ent", "<e1>", "a", "member", "of", "the", "C0019372#ent", "<e2>", "Anatidae", "herpes", "virus", "1", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [7, 8]}}
{"token": ["In", "the", "future", ",", "clinicians", "should", "be", "alert", "to", "novel", "findings", "of", "randomized", "trials", "may", "provide", "insight", "into", "the", "pathogenesis", "of", "these", "C0012634#ent", "<e1>", "and", "the", "contributions", "made", "by", "clinically", "silent", "C0019372#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [31, 32]}}
{"token": ["These", "genes", "are", "very", "polymorphic", "in", "the", "population", ",", "enabling", "studies", "on", "the", "association", "between", "alleles", "at", "specific", "interferon", "loci", "the", "severity", "of", "C0012634#ent", "<e1>", "experimental", "Bovine", "C0019372#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [27, 28]}}
{"token": ["Rat", "C0023899#ent", "<e1>", "contained", "other", "neutral", "proteinases", "one", "of", "these", "was", "a", "C0072402#ent", "<e2>", "an", "apparent", "molecular", "weight", "90", "000", "on", "gel", "chromatography"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [12, 13]}}
{"token": ["In", "Experiment", "2", "chickens", "received", "C0015620#ent", "<e1>", ",", "a", "H2", "receptor", "antagonist", "prior", "to", "injection", "of", "C0026818#ent", "<e2>", "."], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [16, 17]}}
{"token": ["When", "tested", "at", "the", "concentration", "of", "10(-5)M", ",", "C0015620#ent", "<e1>", "enhanced", "the", "contractile", "response", "the", "ileum", "to", "either", "GABA", "or", "C0026818#ent", "<e2>", ",", "while", "cimetidine", "did", "not", "modify", "it", "."], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [20, 21]}}
{"token": ["Recent", "studies", "show", "that", "C0003949#ent", "<e1>", "activates", "DNA", "repair", "enzymes", "such", "as", "C1506647#ent", "<e2>", "APE", ")", "and", "poly", "(ADP-ribose)", "polymerase", "PARP", ")", "."], "h": {"id": "C0003949", "name": "C0003949#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1506647", "name": "C1506647#ent", "pos": [12, 13]}}
{"token": ["The", "wheat", "non-specific", "C1455838#ent", "<e1>", "to", "a", "family", "of", "C0751984#ent", "<e2>", "a", "common", "pattern", "of", "four", "disulphide", "bridges", "."], "h": {"id": "C1455838", "name": "C1455838#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [9, 10]}}
{"token": ["C1415928#ent", "<e1>", "is", "much", "smaller", "than", "the", "protein", "encoded", "by", "its", "C0079429#ent", "<e2>", ",", "suggesting", "that", "it", "results", "from", "a", "highly", "processed", "precursor", "."], "h": {"id": "C1415928", "name": "C1415928#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["Since", "the", "biochemical", "characteristics", "of", "the", "induced", "C0265493#ent", "<e1>", "C1412365#ent", "<e2>", "were", "very", "similar", "to", "those", "of", "rat", "C0265493#ent", "<e1>", "RL4", ",", "we", "hypothesized", "that", "these", "were", "the", "same", "enzymes", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0265493", "name": "C0265493#ent", "pos": [7, 8]}}
{"token": ["Here", ",", "using", "biochemical", "assays", "we", "show", "that", "huntingtin", "(", "C3814032#ent", "<e1>", ")", "interacting", "protein", ",", "C3889135#ent", "<e2>", ",", "is", "a", "neuronal", "palmitoyl", "transferase", "PAT", ")", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889135", "name": "C3889135#ent", "pos": [16, 17]}}
{"token": ["Downregulation", "of", "C3889135#ent", "<e1>", "in", "mouse", "neurons", "expressing", "wild-type", "and", "mutant", "C3814032#ent", "<e2>", "increases", "inclusion", "formation", "whereas", "overexpression", "of", "C3889135#ent", "<e1>", "substantially", "reduces", "inclusions", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3889135", "name": "C3889135#ent", "pos": [2, 3]}}
{"token": ["Moreover", ",", "the", "interaction", "between", "C1419020#ent", "<e1>", "and", "C1421361#ent", "<e2>", "blocked", "DNA", "binding", "C1421361#ent", "<e2>", "."], "h": {"id": "C1419020", "name": "C1419020#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421361", "name": "C1421361#ent", "pos": [8, 9]}}
{"token": ["At", "present", ",", "C1419020#ent", "<e1>", "is", "the", "only", "known", "example", "of", "a", "C1421361#ent", "<e2>", "inhibitor", "encoded", "by", "a", "non-uracil", "containing", "viral", "DNA"], "h": {"id": "C1419020", "name": "C1419020#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421361", "name": "C1421361#ent", "pos": [12, 13]}}
{"token": ["Though", "it", "is", "well", "known", "that", "C0030246#ent", "<e1>", "plantaris", "(", "PPP", ")", "is", "one", "of", "C0162628#ent", "<e2>", "by", "focal", "infection", "the", "tonsils", ",", "its", "etiology", "remains", "unknown", "."], "h": {"id": "C0030246", "name": "C0030246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [15, 16]}}
{"token": ["Smad1", "mediates", "C0377148#ent", "<e1>", "BMP", ")", "signals", ",", "whereas", "C1566790#ent", "<e2>", "functions", "downstream", "of", "TGF-beta", "."], "h": {"id": "C0377148", "name": "C0377148#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [9, 10]}}
{"token": ["Smads", "1/5/8", ",", "activated", "by", "C0377148#ent", "<e1>", "BMP", ")", "signaling", ",", "induce", "ventral", "mesoderm", "C1566790#ent", "<e2>", ",", "activated", "by", "activin-like", "ligands", ",", "induces", "dorsal", "mesoderm"], "h": {"id": "C0377148", "name": "C0377148#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [14, 15]}}
{"token": ["Smad1", "and", "Smad5", "mediate", "intracellular", "signaling", "of", "C0377148#ent", "<e1>", "BMP", ")", ",", "whereas", "C1566790#ent", "<e2>", "and", "Smad3", "transduce", "TGF-beta", "signaling", "."], "h": {"id": "C0377148", "name": "C0377148#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [13, 14]}}
{"token": ["The", "C1704263#ent", "<e1>", "reduced", "GSH", "and", "increased", "GSSG", "levels", "in", "C2939465#ent", "<e2>", "erythrocytes", "in", "a", "dose-dependent", "manner", "(", "0.5", "-", "10", "mg/ml", ")", ",", "but", "not", "in", "normal", "erythrocytes", "."], "h": {"id": "C1704263", "name": "C1704263#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2939465", "name": "C2939465#ent", "pos": [10, 11]}}
{"token": ["Our", "report", "emphasizes", "that", ",", "although", "unusual", ",", "C0263445#ent", "<e1>", "be", "complicated", "by", "an", "C3898123#ent", "<e2>", "bone", "lesions"], "h": {"id": "C0263445", "name": "C0263445#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3898123", "name": "C3898123#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "HIV", "encephalitis", "C0221232#ent", "<e1>", ")", "showed", "intense", "somato-dendritic", "neuronal", "SDF-1alpha", "immunoreactivity", ",", "while", "C0221232#ent", "<e1>", "negative", "patients", "with", "neurodegeneration", "had", "a", "significant", "decrease", "in", "C1332817#ent", "<e1>", "immunoreactivity", "."], "h": {"id": "C0221232", "name": "C0221232#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332817", "name": "C1332817#ent", "pos": [26, 27]}}
{"token": ["Oxygen", "free", "radicals", "OFR", ")", "exert", "direct", "effects", "on", "the", "electrophysiologic", "properties", "of", "a", "variety", "of", "cardiac", "preparations", "well-oxygenated", "conditions", "and", "have", "been", "implicated", "in", "the", "C4255166#ent", "<e1>", "of", "arrhythmias", "associated", "with", "C0151744#ent", "<e2>", "reperfusion", "."], "h": {"id": "C4255166", "name": "C4255166#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [32, 33]}}
{"token": ["Furthermore", ",", "incubation", "of", "HUVECs", "with", "C1416403#ent", "<e1>", "induced", "phosphorylation", "of", "ERK1/2", ",", "C1705633#ent", "<e2>", ",", "and", "JNK", "."], "h": {"id": "C1416403", "name": "C1416403#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [13, 14]}}
{"token": ["Analysis", "of", "the", "activities", "of", "antioxidant", "enzymes", "C1421531#ent", "<e1>", "that", "changes", "in", "these", "C3540772#ent", "<e2>", "in", "hypoxic", "PAEC", "were", "not", "responsible", "for", "the", "increased", "susceptibility", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [13, 14]}}
{"token": ["Results", "show", "that", "the", "enzyme", "systems", "differ", "from", "DT-diaphorase", ",", "aldehyde", "oxidase", "C1421531#ent", "<e1>", "ketone", "reductase", "aldose", "reductase", "aldehyde", "reductase", "alcohol", "dehydrogenase", "known", "cytosolic", "C3540772#ent", "<e2>", "responsible", "for", "xenobiotic", "metabolism"], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [24, 25]}}
{"token": ["The", "work", "emphasizes", "the", "importance", "of", "combined", "genetic", "and", "biochemical", "study", "of", "C1421531#ent", "<e1>", "variants", "in", "probing", "the", "structure", "and", "function", "of", "C3540772#ent", "<e2>", "of", "this", "class", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [22, 23]}}
{"token": ["Halogenation", "by", "C1425826#ent", "<e1>", "required", "the", "addition", "of", "RebF", ",", "which", "catalyzes", "the", "C0068803#ent", "<e2>", "reduction", "of", "FAD", "to", "provide", "FADH2", "for", "the", "halogenase", "."], "h": {"id": "C1425826", "name": "C1425826#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0068803", "name": "C0068803#ent", "pos": [13, 14]}}
{"token": ["The", "autopsy", "revealed", "superior", "C0338575#ent", "<e1>", "be", "the", "cause", "of", "papilledema", ",", "which", "indicate", "that", "C0270639#ent", "<e2>", "develop", "with", "such", "a", "hemorrhagic", "disease", "ITP", "."], "h": {"id": "C0338575", "name": "C0338575#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0270639", "name": "C0270639#ent", "pos": [15, 16]}}
{"token": ["The", "His-to-Pro", "mutations", "resulted", "in", "decreased", "gyration", "radius", "(", "C4283853#ent", "<e1>", ")", "values", "and", "surface", "accessibility", "of", "the", "mutant", "C0030956#ent", "<e2>", "under", "the", "simulation", "times", "."], "h": {"id": "C4283853", "name": "C4283853#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}}
{"token": ["Peptide", "mapping", "studies", "showed", "that", "each", "of", "polypeptides", "C3", "C4283853#ent", "<e1>", ",", "and", "C5", "had", "a", "C0030956#ent", "<e2>", "composition", "similar", "to", "the", "M", "protein"], "h": {"id": "C4283853", "name": "C4283853#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}}
{"token": ["The", "results", "confirm", "a", "significant", "rise", "of", "C1332684#ent", "<e1>", "activity", "in", "patients", "with", "IDDM", "complicated", "with", "C0011881#ent", "<e2>"], "h": {"id": "C1332684", "name": "C1332684#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "exacerbations", "of", "C0008677#ent", "<e1>", "associated", "with", "marked", "airway", "C1306759#ent", "<e2>", "and", "with", "a", "milder", "increase", "in", "the", "number", "of", "neutrophils", ",", "activated", "T-lymphocytes", ",", "and", "TNF-alpha-positive", "cells", "in", "the", "bronchial", "mucosa"], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [11, 12]}}
{"token": ["The", "overall", "HIV", "prevalence", "was", "13.1", "%", "in", "C1842796#ent", "<e1>", "patients", ",", "14.2", "%", "in", "C0041296#ent", "<e2>", "patients", ",", "and", "5.6", "%", "in", "control", "patients", "."], "h": {"id": "C1842796", "name": "C1842796#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [15, 16]}}
{"token": ["The", "nucleotide", "sequence", "the", "restriction", "fragment", "hybridizing", "with", "the", "oligonucleotide", "confirms", "the", "existence", "of", "one", "exon", "encoding", "C3539946#ent", "<e1>", "-", "93", "of", "human", "cystatin", "C", "its", "relationship", "to", "C0086509#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0086509", "name": "C0086509#ent", "pos": [28, 29]}}
{"token": ["The", "other", "16", "half-cystine", "residues", "linked", "consecutively", "to", "form", "eight", "loops", "of", "4", "-", "20", "C3539946#ent", "<e1>", "these", "loops", "are", "lined", "up", "in", "the", "heavy-chain", "portion", "the", "C0086509#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086509", "name": "C0086509#ent", "pos": [27, 28]}}
{"token": ["The", "L", "chains", "human", "and", "bovine", "kininogens", "in", "the", "protein", "lengths", "well", "as", "in", "some", "C3539946#ent", "<e1>", "for", "the", "processing", "of", "the", "C0086509#ent", "<e2>", "by", "kallikrein", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086509", "name": "C0086509#ent", "pos": [22, 23]}}
{"token": ["Co-infections", "such", "as", "Mycobacterium", "tuberculosis", "TB", ")", "and", "C1535939#ent", "<e1>", "affect", "the", "progress", "of", "C0019693#ent", "<e2>", "speed", "the", "onset", "of", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [14, 15]}}
{"token": ["HIV-associated", "nephropathy", "HIVAN", ")", "and", "C1535939#ent", "<e1>", "PCP", ")", "typically", "occur", "during", "advanced", "C0019693#ent", "<e2>"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [13, 14]}}
{"token": ["C1421998#ent", "<e1>", "is", "a", "known", "C0172870#ent", "<e2>", "and", "we", "now", "show", "that", "it", "has", "strong", "uric", "acid", "activity", "in", "Xenopus", "laevis", "oocytes", "."], "h": {"id": "C1421998", "name": "C1421998#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0172870", "name": "C0172870#ent", "pos": [5, 6]}}
{"token": ["Increased", "in", "vitro", "kinase", "activity", ",", "to", "a", "lesser", "extent", ",", "in", "vivo", "tyrosine", "phosphorylation", "well", "as", "the", "elevated", "association", "of", "PI", "3-kinase", "with", "C1334088#ent", "<e1>", "to", "be", "correlated", "with", "the", "transforming", "potential", "of", "IGFR", "C1564139#ent", "<e2>"], "h": {"id": "C1334088", "name": "C1334088#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1564139", "name": "C1564139#ent", "pos": [35, 36]}}
{"token": ["The", "ultrasonographic", "measurements", "of", "the", "adrenal", "glands", "24", "C0012634#ent", "<e1>", "cats", "without", "a", "clinically", "or", "laboratory", "identifiable", "C0014130#ent", "<e2>", "were", "evaluated", "retrospectively", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "urticaria", "may", "be", "associated", "with", "C0012634#ent", "<e1>", "and", "conditions", "characterized", "by", "hormonal", "changes", ",", "including", "C0014130#ent", "<e2>", ",", "menstrual", "cycle", "pregnancy", ",", "menopause", "and", "hormonal", "contraceptives", "hormone", "replacement", "therapy"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [18, 19]}}
{"token": ["Forty-five", "patients", "with", "C0020538#ent", "<e1>", "treated", "for", "2", "months", "with", "either", "C0025859#ent", "<e2>", "or", "pindolol", "in", "a", "randomized", ",", "blind", ",", "crossover", "study"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [11, 12]}}
{"token": ["T-cells", "exposed", "to", "C0338271#ent", "<e1>", "are", "nonresponsive", "to", "C0026249#ent", "<e2>", "unless", "zinc", "is", "added", "."], "h": {"id": "C0338271", "name": "C0338271#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [8, 9]}}
{"token": ["In", "fact", ",", "we", "have", "found", "that", "human", "leptin", "stimulates", "C0597721#ent", "<e1>", "transducer", "and", "activator", "of", "transcription", "STAT", ")", ",", "phosphatidylinositol", "3-kinase", "C1705325#ent", "<e2>", "and", "mitogen-activated", "protein", "kinase", "MAPK", ")", "pathways", "in", "PBMC", "."], "h": {"id": "C0597721", "name": "C0597721#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705325", "name": "C1705325#ent", "pos": [22, 23]}}
{"token": ["We", "have", "searched", "for", "mutations", "in", "the", "maleylacetoacetate", "isomerase", "gene", "four", "cases", "of", "unexplained", "severe", "C0085605#ent", "<e1>", "infancy", "with", "clinical", "similarities", "to", "C0268483#ent", "<e2>", "pseudotyrosinemia", ")", "."], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0268483", "name": "C0268483#ent", "pos": [22, 23]}}
{"token": ["No", "RNA", "or", "protein", "upregulation", "observed", "for", "ABCB6", ",", "ABCF1", ",", "ABCC10", ",", "ABCC4", ",", "ABCB2", "and", "C1336576#ent", "<e1>", ",", "but", "an", "increased", "expression", "was", "detected", "for", "C2982462#ent", "<e2>", "mRNA", "in", "GLC4-MITO", "."], "h": {"id": "C1336576", "name": "C1336576#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2982462", "name": "C2982462#ent", "pos": [27, 28]}}
{"token": ["Unlike", "conventional", "C1416692#ent", "<e1>", ",", "members", "of", "the", "Kin", "I", "family", "microtubule-depolymerizing", "C0014442#ent", "<e2>", ",", "which", "are", "expected", "to", "be", "molecules", "that", "could", "generate", "poleward", "forces", "."], "h": {"id": "C1416692", "name": "C1416692#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["A", "transient", "muscle", "paralysis", "periodic", "paralysis", "C0015967#ent", "<e1>", "episodes", "of", "C0024530#ent", "<e2>", "has", "been", "described", "in", "some", "patients", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [10, 11]}}
{"token": ["C1333572#ent", "<e1>", ",", "a", "human", "homologue", "of", "daf-16", ",", "contains", "three", "C0812228#ent", "<e2>", "sites", "and", "is", "expressed", "in", "the", "liver", "."], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [11, 12]}}
{"token": ["A", "time-course", "study", "revealed", "that", "dephosphorylation", "of", "C1705050#ent", "<e1>", "by", "TC-PTP", "was", "delayed", "compared", "with", "that", "by", "cytosolic", "C1335281#ent", "<e2>", "due", "to", "nuclear", "localization", "TC-PTP", "throughout", "PRL", "stimulation", "in", "mammary", "epithelial", "cells"], "h": {"id": "C1705050", "name": "C1705050#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335281", "name": "C1335281#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "fluphenazine", ",", "C0008286#ent", "<e1>", "or", "spiperone", ",", "C2936804#ent", "<e2>", "impaired", "aversive", "learning", "affecting", "appetitive", "learning", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936804", "name": "C2936804#ent", "pos": [10, 11]}}
{"token": ["C1336926#ent", "<e1>", ",", "a", "hematopoiesis-specific", "exchange", "factor", "for", "C0812228#ent", "<e2>", ",", "was", "constitutively", "tyrosine", "phosphorylated", "in", "primary", "lymphomas", "Bcr/Abl", "P190", "transgenic", "mice", "suggesting", "inappropriate", "Rac", "activation"], "h": {"id": "C1336926", "name": "C1336926#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [8, 9]}}
{"token": ["Histologic", "evaluation", "revealed", "30", "functional", "cysts", "36", "endometriotic", "cysts", "11", "dermoids", ",", "9", "serous", "cystadenomas", "3", "mucinous", "cystadenomas", "11", "parovarian", "cysts", "19", "cases", "of", "C0221376#ent", "<e1>", "and", "2", "cases", "of", "C0041323#ent", "<e2>", "."], "h": {"id": "C0221376", "name": "C0221376#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [30, 31]}}
{"token": ["(", "1", ")", "C1667052#ent", "<e1>", "belongs", "to", "a", "new", "class", "of", "C0003451#ent", "<e2>", "to", "block", "entry", "of", "HIV-1", "into", "CD4", "+", "T-cells", "via", "the", "CCR5", "coreceptor"], "h": {"id": "C1667052", "name": "C1667052#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "PI3K", "inhibitors", "platelet", "spreading", "both", "C1336938#ent", "<e1>", "and", "fibrinogen", ",", "indicating", "a", "role", "for", "C1705590#ent", "<e2>", "integrin", "outside-in", "signaling", "distinct", "from", "that", "in", "GPIb-IX-mediated", "inside-out", "signaling", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [17, 18]}}
{"token": ["Since", "C1412728#ent", "<e1>", "promotes", "the", "degradation", "of", "angiotensin", "II", "a", "decrease", "in", "C1412728#ent", "<e1>", "activity", "could", "lead", "to", "the", "development", "of", "C0268731#ent", "<e1>"], "h": {"id": "C1412728", "name": "C1412728#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [21, 22]}}
{"token": ["These", "features", "were", "most", "likely", "due", "to", "increased", "production", "of", "and", "enhanced", "responsiveness", "to", "C1705750#ent", "<e1>", "and", "IL-6", "during", "C0029408#ent", "<e2>", "in", "these", "mice", "."], "h": {"id": "C1705750", "name": "C1705750#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [19, 20]}}
{"token": ["To", "understand", "the", "role", "of", "the", "C3888092#ent", "<e1>", "leukemia", ",", "we", "must", "understand", "the", "normal", "functions", "C1423088#ent", "<e2>", "and", "MKL", "."], "h": {"id": "C3888092", "name": "C3888092#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1423088", "name": "C1423088#ent", "pos": [16, 17]}}
{"token": ["DNA", "sequencing", "these", "four", "genes", ",", "C1416997#ent", "<e1>", ",", "pduF", ",", "glnA", ",", "and", "C1427605#ent", "<e2>", ",", "showed", "no", "genetic", "diversity", "the", "isolates", "tested", ",", "with", "a", "100", "%", "identity", "in", "nucleotide", "sequence"], "h": {"id": "C1416997", "name": "C1416997#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1427605", "name": "C1427605#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "suggest", "the", "effectiveness", "and", "tolerability", "of", "a", "C1709545#ent", "<e1>", "A.", "pichinchensis", "in", "treatment", "of", "patients", "with", "C0040247#ent", "<e2>"], "h": {"id": "C1709545", "name": "C1709545#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [18, 19]}}
{"token": ["C0051809#ent", "<e1>", "may", "be", "useful", "in", "young", "patients", "with", "C0836924#ent", "<e2>", "who", "are", "symptomatic", "."], "h": {"id": "C0051809", "name": "C0051809#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0836924", "name": "C0836924#ent", "pos": [9, 10]}}
{"token": ["Although", "C0051809#ent", "<e1>", "is", "widely", "used", "in", "the", "treatment", "of", "C0836924#ent", "<e2>", "in", "myeloproliferative", "diseases", "there", "is", "currently", "limited", "information", "on", "the", "efficacy", "and", "toxicity", "of", "its", "long-term", "use", "."], "h": {"id": "C0051809", "name": "C0051809#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0836924", "name": "C0836924#ent", "pos": [10, 11]}}
{"token": ["IL-8", "increased", "DNA", "synthesis", "Caco2", "in", "a", "dose", "dependent", "manner", "and", "this", "was", "inhibited", "by", "C1314771#ent", "<e1>", ",", "EGFR", "kinase", ",", "and", "C0003015#ent", "<e2>"], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [22, 23]}}
{"token": ["C0752235#ent", "<e1>", "LNB", ")", "has", "repeatedly", "been", "reported", "to", "cause", "C0042384#ent", "<e2>"], "h": {"id": "C0752235", "name": "C0752235#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [10, 11]}}
{"token": ["When", "the", "data", "from", "all", "fifteen", "trials", "were", "pooled", "and", "a", "summary", "relative", "risk", "estimate", "calculated", ",", "there", "was", "a", "significant", "benefit", "of", "C0023660#ent", "<e1>", "treatment", "in", "preventing", "C0042510#ent", "<e2>", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [28, 29]}}
{"token": ["Mexiletine", "and", "C0023660#ent", "<e1>", "elevated", "both", "RE", "and", "C0042510#ent", "<e2>", "thresholds", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [8, 9]}}
{"token": ["C0023660#ent", "<e1>", "decreased", "inducibility", "of", "ventricular", "fibrillation", "C0042510#ent", "<e2>", ")", "during", "ischaemia", "from", "86", "to", "25", "%", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [7, 8]}}
{"token": ["These", "results", "demonstrate", "that", "C0090306#ent", "<e1>", "is", "a", "valuable", "drug", "for", "the", "treatment", "of", "C0017612#ent", "<e2>"], "h": {"id": "C0090306", "name": "C0090306#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "PPARalphatr", "interfered", "with", "transcriptional", "activity", "other", "nuclear", "receptors", "as", "PPARgamma", ",", "C3273648#ent", "<e1>", "and", "glucocorticoid", "receptor-alpha", "which", "share", "C1530423#ent", "<e2>", "protein/p300", "as", "a", "coactivator", "."], "h": {"id": "C3273648", "name": "C3273648#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1530423", "name": "C1530423#ent", "pos": [21, 22]}}
{"token": ["Intravenous", "injection", "of", "C0053180#ent", "<e1>", "a", "dose", "close", "to", "70", "micrograms/kg", ",", "and", "C0004259#ent", "<e2>", "in", "the", "low", "dose", "30", "micrograms/kg", "inhibited", "the", "acid", "response", "sham", "feeding", "by", "about", "65", "%", "."], "h": {"id": "C0053180", "name": "C0053180#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [13, 14]}}
{"token": ["We", "also", "examined", "the", "effects", "of", "cotransfection", "with", "a", "combination", "of", "the", "C1705969#ent", "<e1>", "and", "the", "C1332424#ent", "<e2>", "osteoblastic", "cell", "differentiation"], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332424", "name": "C1332424#ent", "pos": [16, 17]}}
{"token": ["In", "the", "presence", "of", "both", "C0004147#ent", "<e1>", "and", "prazosin", ",", "C1823460#ent", "<e2>", "of", "guinea", "pig", "left", "atria", "induced", "a", "positive", "inotropic", "response", "it", "had", "a", "slow", "onset", "and", "decay", "."], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1823460", "name": "C1823460#ent", "pos": [10, 11]}}
{"token": ["This", "study", "investigated", "the", "effects", "of", "NO", "C0017887#ent", "<e1>", "GTN", ")", "upon", "measures", "of", "cardiac", "vagal", "activity", "in", "C0018801#ent", "<e2>"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}}
{"token": ["Besides", "other", "organic", "nitrates", "nitroglycerin", "(", "C0017887#ent", "<e1>", "GTN", ")", "has", "been", "used", "to", "treat", "C0018801#ent", "<e2>", "due", "to", "ischemic", "heart", "disease"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [15, 16]}}
{"token": ["Autopsy", ",", "in", "a", "single", "case", ",", "showed", "diffuse", "deposits", "beta-amyloid", "throughout", "the", "C0001614#ent", "<e1>", "with", "frequent", "C0029134#ent", "<e2>", "plaques", "and", "neurofibrillary", "tangles"], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0029134", "name": "C0029134#ent", "pos": [17, 18]}}
{"token": ["Vulnerability", "of", "the", "hippocampus", "and", "C0001614#ent", "<e1>", "to", "age-related", "pathology", "such", "as", "beta-amyloidosis", "and", "C0029134#ent", "<e2>", "plaque", "formation", "may", "relate", "to", "the", "extended", "period", "of", "cholinergic", "synaptic", "sculpting", "in", "these", "areas", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029134", "name": "C0029134#ent", "pos": [14, 15]}}
{"token": ["These", "enzymes", "together", "with", "other", "C0064833#ent", "<e1>", "enzymes", ",", "e.g.", "hydrolases", "and", "C0030016#ent", "<e2>", ",", "might", "alter", "the", "erythrocyte", "membrane", "and", "thus", "influence", "the", "storage", "quality", "of", "the", "prepared", "red", "cell", "concentrate"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [12, 13]}}
{"token": ["Buchnera", "aphidicola", "the", "prokaryotic", "endosymbiont", "of", "aphids", ",", "complements", "C0175683#ent", "<e1>", "the", "synthesis", "and", "provision", "of", "several", "essential", "C3539946#ent", "<e2>"], "h": {"id": "C0175683", "name": "C0175683#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [18, 19]}}
{"token": ["Platelet-activating", "factor", "PAF", ")", "receptor", "antagonists", ",", "C0024027#ent", "<e1>", ",", "and", "the", "C0033681#ent", "<e2>", "PTK", ")", "inhibitor", "genistein", "each", "reduced", "H2O2", "secretion", "by", "Macs", "maintained", "on", "oxLDL-containing", "matrices", "by", "approximately", "60", "%", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [12, 13]}}
{"token": ["Our", "results", "suggest", "that", "C0033223#ent", "<e1>", "is", "a", "more", "effective", "2nd", "agent", "IA", "C0796074#ent", "<e2>", "or", "AZQ", "following", "radiation", "and", "nitrosourea", "failure"], "h": {"id": "C0033223", "name": "C0033223#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [13, 14]}}
{"token": ["The", "efficacy", "of", "C0064474#ent", "<e1>", "(", "CLS", ")", "against", "experimental", "schistosomiasis", "mansoni", "using", "C0032911#ent", "<e2>", "(", "PZQ", ")", "as", "a", "therapeutic", "control", "evaluated", "."], "h": {"id": "C0064474", "name": "C0064474#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [13, 14]}}
{"token": ["Analysis", "of", "a", "Lys-C", "digest", "of", "the", "probe", "II-labeled", "CYP", "2B4", "revealed", "a", "single", "labeled", "C0633070#ent", "<e1>", "corresponding", "to", "position", "192", "-", "197", "of", "the", "C3538766#ent", "<e2>", "."], "h": {"id": "C0633070", "name": "C0633070#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3538766", "name": "C3538766#ent", "pos": [25, 26]}}
{"token": ["The", "C1442804#ent", "<e1>", "a", "unique", "member", "of", "the", "C0038085#ent", "<e2>", "non-receptor", "protein", "tyrosine", "kinases", "principal", "role", "is", "to", "regulate", "signals", "through", "inhibitory", "receptors", "promoting", "signal", "attenuation"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [8, 9]}}
{"token": ["C1442804#ent", "<e1>", "is", "a", "member", "of", "the", "C0038085#ent", "<e2>", "non-receptor", "protein", "tyrosine", "kinases", "is", "predominantly", "expressed", "in", "haematopoietic", "tissues"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [7, 8]}}
{"token": ["The", "signaling", "event", "originating", "in", "the", "caveolae-like", "domains", "in", "response", "to", "FGF-2", "appeared", "to", "require", "the", "activation", "of", "at", "least", "Fyn", "and", "C1442804#ent", "<e1>", ",", "two", "members", "of", "the", "C0038085#ent", "<e2>", "tyrosine", "kinases"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [22, 23]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [29, 30]}}
{"token": ["It", "is", "reported", "that", "persons", "with", "C4288927#ent", "<e1>", "patients", "with", "C0003873#ent", "<e2>", "Crohn's", "disease", "susceptible", "to", "Mycobacterium", "tuberculosis"], "h": {"id": "C4288927", "name": "C4288927#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}}
{"token": ["Because", "of", "the", "C0242898#ent", "<e1>", "spinal", "and", "C1706349#ent", "<e2>", "vestibular", "projections", "assume", "that", "these", "VN", "neurons", "with", "collateral", "projection", "C0242898#ent", "<e1>", "."], "h": {"id": "C1706349", "name": "C1706349#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [3, 4]}}
{"token": ["In", "addition", ",", "C1414828#ent", "<e1>", "coimmunoprecipitates", "with", "C0164786#ent", "<e2>", "."], "h": {"id": "C1414828", "name": "C1414828#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [7, 8]}}
{"token": ["The", "interactions", "of", "C0009905#ent", "<e1>", "OCA", "'s", ")", "with", "C3714649#ent", "<e2>", "were", "studied", "in", "a", "large", "population", "of", "women", "."], "h": {"id": "C0009905", "name": "C0009905#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [9, 10]}}
{"token": ["Unilateral", "injection", "of", "C0006945#ent", "<e1>", "(", "0.2", "-", "3.2", "micrograms/0.5", "microliters", "into", "the", "rostral", "C1823503#ent", "<e2>", "caused", "catalepsy", "which", "appeared", "rapidly", "and", "was", "short-lasting", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823503", "name": "C1823503#ent", "pos": [14, 15]}}
{"token": ["The", "pigment", "is", "the", "product", "of", "reactions", "between", "C0012322#ent", "<e1>", "(", "DHA", ")", "and", "C3539947#ent", "<e2>", "the", "stratum", "corneum"], "h": {"id": "C0012322", "name": "C0012322#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [14, 15]}}
{"token": ["C0001339#ent", "<e1>", "reported", "in", "17", "%", "of", "pediatric", "patients", "with", "acquired", "C0021051#ent", "<e2>", "AIDS", ")", ",", "is", "said", "to", "have", "a", "poor", "prognosis"], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [11, 12]}}
{"token": ["Work", "is", "in", "progress", "to", "clone", "CLN1", "and", "C1413495#ent", "<e1>", "and", "to", "map", "C1540042#ent", "<e2>", "."], "h": {"id": "C1413495", "name": "C1413495#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1540042", "name": "C1540042#ent", "pos": [13, 14]}}
{"token": ["This", "effect", "was", "blocked", "by", "pretreatment", "with", "the", "sympathetic", "ganglionic", "blocker", "C0008211#ent", "<e1>", "2", "mg/kg", ")", "or", "the", "beta-adrenergic", "receptor", "blocker", "C0033497#ent", "<e2>", "(", "2", "mg/kg", ")", ",", "implicating", "the", "involvement", "of", "the", "sympathetic", "system"], "h": {"id": "C0008211", "name": "C0008211#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "pretreatments", "with", "a", "ganglionic", "blocking", "agent", "C0008211#ent", "<e1>", ")", "and", "a", "beta-adrenergic", "receptor", "antagonist", "C0033497#ent", "<e2>", ")", "completely", "reversed", "the", "suppressive", "effect"], "h": {"id": "C0008211", "name": "C0008211#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [17, 18]}}
{"token": ["The", "suppressive", "effect", "urocortin", "was", "abolished", "by", "pretreatment", "with", "a", "ganglionic", "blocking", "agent", "C0008211#ent", "<e1>", ")", "or", "a", "beta-adrenergic", "receptor", "antagonist", "C0033497#ent", "<e2>", ")", ",", "but", "not", "by", "adrenalectomy", "."], "h": {"id": "C0008211", "name": "C0008211#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [21, 22]}}
{"token": ["We", "have", "generated", "mice", "carrying", "an", "C0694883#ent", "<e1>", "exon", "2", "8", "deletion", "by", "C0079429#ent", "<e2>", "targeting", "in", "embryonic", "stem", "cells"], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["Electrophoretic", "profiles", "of", "penicillin-binding", "proteins", "PBPs", ")", "showed", "a", "decrease", "in", "PBP", "1A", "strains", "C1415891#ent", "<e1>", "and", "IpR2", "compared", "with", "C1864770#ent", "<e2>", "and", "ATCC", "29906", "."], "h": {"id": "C1415891", "name": "C1415891#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1864770", "name": "C1864770#ent", "pos": [20, 21]}}
{"token": ["Strain", "C1415891#ent", "<e1>", "was", "isolated", "in", "the", "same", "sample", "as", "a", "P.", "mirabilis", "C1864770#ent", "<e2>", "which", "was", "susceptible", "to", "imipenem", "and", "mecillinam", "."], "h": {"id": "C1415891", "name": "C1415891#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1864770", "name": "C1864770#ent", "pos": [13, 14]}}
{"token": ["When", "patients", "with", "severe", "compromise", "of", "anatomic", "barriers", "or", "C0035204#ent", "<e1>", "excluded", ",", "94", "%", "of", "all", "patients", "with", "C0036690#ent", "<e2>", "had", "an", "AGC", "of", "less", "than", "200/mm3", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [19, 20]}}
{"token": ["The", "compounds", "were", "assayed", "against", "C0036572#ent", "<e1>", "induced", "by", "maximal", "electroshock", "C3714506#ent", "<e2>", ")", "and", "pentylenetetrazole", "(", "scMet", ")", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714506", "name": "C3714506#ent", "pos": [11, 12]}}
{"token": ["Both", "drugs", "were", "considerably", "more", "potent", "to", "C0036572#ent", "<e1>", "epileptic", "rats", "and", "gerbils", "than", "in", "the", "traditional", "C3714506#ent", "<e2>", "and", "pentylenetetrazol", "mouse", "models"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3714506", "name": "C3714506#ent", "pos": [17, 18]}}
{"token": ["Intramedullary", "sarcoidosis", "a", "rare", "first", "manifestation", "of", "the", "disease", "and", "it", "can", "mimic", "an", "intramedullary", "tumor", "which", "is", "often", "manifested", "with", "symptoms", "that", "initiate", "from", "C0037926#ent", "<e1>", "resulting", "in", "paraparesis", ",", "C0152027#ent", "<e2>", "sphincter", "dysfunction"], "h": {"id": "C0037926", "name": "C0037926#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0152027", "name": "C0152027#ent", "pos": [31, 32]}}
{"token": ["Tolterodine", "was", "recently", "approved", "for", "the", "treatment", "of", "C0015732#ent", "<e1>", "and", "overactive", "bladder", "adults", ",", "and", "has", "fewer", "side", "effects", "C0069805#ent", "<e2>", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0069805", "name": "C0069805#ent", "pos": [20, 21]}}
{"token": ["Significant", "reductions", "in", "C0015732#ent", "<e1>", "episodes", "following", "transdermal", "C0069805#ent", "<e2>", "treatment", "were", "also", "observed", "in", "two", "further", "studies", "and", "the", "clinical", "efficacy", "similar", "to", "that", "of", "oral", "tolterodine", "or", "oral", "C0069805#ent", "<e2>", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0069805", "name": "C0069805#ent", "pos": [8, 9]}}
{"token": ["Accordingly", ",", "significantly", "prolonged", "half-times", "of", "dissociation", "of", "cyt", "c", "liposomes", "by", "NaCl", ",", "C2744579#ent", "<e1>", ",", "and", "different", "cationic", "proteins", "measured", "upon", "increasing", "C1333359#ent", "<e2>", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333359", "name": "C1333359#ent", "pos": [24, 25]}}
{"token": ["We", "encountered", "a", "male", "infant", "with", "C0270726#ent", "<e1>", "with", "megalencephaly", "and", "hydrocephalus", "as", "a", "neonate", "and", "subtle", "C0036572#ent", "<e2>", "at", "3", "months", "of", "age", "."], "h": {"id": "C0270726", "name": "C0270726#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [17, 18]}}
{"token": ["Localized", "MRS", "has", "been", "performed", "using", "short", "stimulated-echo", "times", "in", "various", "C0042075#ent", "<e1>", "stroke", ",", "multiple", "sclerosis", "and", "C0270612#ent", "<e2>"], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0270612", "name": "C0270612#ent", "pos": [18, 19]}}
{"token": ["SHS", "significantly", "increased", "tumor", "size", "weight", ",", "capillary", "density", "VEGF", "and", "C1337092#ent", "<e1>", "levels", ",", "and", "circulating", "endothelial", "progenitor", "cells", "C0169014#ent", "<e2>", ")", "."], "h": {"id": "C1337092", "name": "C1337092#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0169014", "name": "C0169014#ent", "pos": [20, 21]}}
{"token": ["These", "effects", "of", "SHS", "are", "associated", "with", "increases", "in", "plasma", "VEGF", "and", "C1337092#ent", "<e1>", "levels", ",", "and", "C0169014#ent", "<e2>", ",", "mediated", "in", "part", "by", "isoprenylation", "and", "nicotinic", "acetylcholine", "receptors"], "h": {"id": "C1337092", "name": "C1337092#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0169014", "name": "C0169014#ent", "pos": [17, 18]}}
{"token": ["C2986638#ent", "<e1>", "influences", "occur", "in", "C0030196#ent", "<e2>", "and", "trunk", "(", "somitic", ")", "muscle", ",", "but", "are", "particularly", "strong", "in", "jaw-closing", "muscles", "and", "extraocular", "muscles", "express", "some", "unique", "myofibrillar", "proteins"], "h": {"id": "C2986638", "name": "C2986638#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [5, 6]}}
{"token": ["Mitochondrial", "trifunctional", "protein", "MTP", ")", ",", "an", "enzyme", "complex", "in", "fatty", "acid", "beta-oxidation", "is", "the", "potential", "site", "of", "two", "documented", "defects", ":", "long-chain", "3-hydroxyacyl-coenzyme", "A", "dehydrogenase", "C1415460#ent", "<e1>", ")", "and", "MTP", "C0268487#ent", "<e2>", "."], "h": {"id": "C1415460", "name": "C1415460#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [31, 32]}}
{"token": ["Thus", ",", "the", "symptomatic", "differences", "of", "organophosphate-induced", "neurotoxicity", "between", "mice", "and", "humans", "are", "probably", "not", "related", "to", "the", "diverse", "amplitudes", "of", "intracellular", "C0001477#ent", "<e1>", "produced", "by", "C3273549#ent", "<e2>", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3273549", "name": "C3273549#ent", "pos": [26, 27]}}
{"token": ["A", "one-chamber", "gastrointestinal", "therapeutic", "system", "(", "C1415353#ent", "<e1>", ")", "is", "proposed", "which", "is", "capable", "of", "delivering", "insoluble", "C0013227#ent", "<e2>", "at", "a", "relatively", "constant", "rate", "."], "h": {"id": "C1415353", "name": "C1415353#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["Among", "the", "PKC", "theta-activated", "signalings", ",", "we", "presented", "evidence", "that", "the", "expression", "of", "C1705316#ent", "<e1>", "is", "mediated", "through", "NFkappaB", "but", "not", "through", "MEK", "or", "C0248813#ent", "<e2>"], "h": {"id": "C1705316", "name": "C1705316#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [24, 25]}}
{"token": ["The", "investigation", "included", "simulated", "docking", "experiments", "to", "fit", "olanzapine", "within", "the", "binding", "pocket", "of", "C0244988#ent", "<e1>", "followed", "by", "in", "vitro", "C0027203#ent", "<e2>", "inhibition", "assay", "as", "well", "as", "in", "vivo", "subchronic", "animal", "treatment"], "h": {"id": "C0244988", "name": "C0244988#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [20, 21]}}
{"token": ["Although", "the", "expression", "of", "the", "metastases-associated", "gene", "C1417405#ent", "<e1>", "correlates", "with", "tumor", "metastases", "its", "role", "in", "C0172537#ent", "<e2>", "expression", "is", "unknown", "."], "h": {"id": "C1417405", "name": "C1417405#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [16, 17]}}
{"token": ["A", "randomized", "double-blind", "placebo-controlled", "study", "carried", "out", "in", "56", "patients", "with", "essential", "C0013395#ent", "<e1>", "to", "investigate", "the", "therapeutic", "efficacy", "of", "C0008783#ent", "<e2>", "in", "providing", "symptomatic", "relief", "."], "h": {"id": "C0013395", "name": "C0013395#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [20, 21]}}
{"token": ["There", "were", "significantly", "fewer", "weeks", "of", "C0013395#ent", "<e1>", "and", "better", "general", "well-being", "the", "C0008783#ent", "<e2>", "group", "as", "compared", "to", "the", "placebo", "group", "."], "h": {"id": "C0013395", "name": "C0013395#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [13, 14]}}
{"token": ["This", "prolongation", "of", "capsaicin-induced", "analgesia", "during", "inflammation", "was", "mediated", "through", "C1421429#ent", "<e1>", "since", "it", "was", "completely", "blocked", "by", "coadministration", "of", "C0108304#ent", "<e2>", "(", "10", "microg", ")", "."], "h": {"id": "C1421429", "name": "C1421429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0108304", "name": "C0108304#ent", "pos": [20, 21]}}
{"token": ["Although", "blockade", "of", "capsaicin-induced", "C1421429#ent", "<e1>", "activation", "has", "been", "demonstrated", "in", "vitro", "in", "vivo", "the", "antagonist", "C0108304#ent", "<e2>", ",", "efficacy", "in", "rat", "models", "of", "chronic", "pain", "not", "been", "observed", "with", "this", "compound", "."], "h": {"id": "C1421429", "name": "C1421429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0108304", "name": "C0108304#ent", "pos": [16, 17]}}
{"token": ["To", "search", "for", "mutations", "in", "the", "coding", "exons", "the", "C1414830#ent", "<e1>", "women", "diagnosed", "with", "C0032460#ent", "<e2>", "PCOS", ")", "."], "h": {"id": "C1414830", "name": "C1414830#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [14, 15]}}
{"token": ["Maximal", "absorption", "of", "C0018242#ent", "<e1>", "is", "achieved", "by", "administration", "of", "the", "C1254351#ent", "<e2>", "as", "a", "solid", "solution", "polyethylene", "glycol"], "h": {"id": "C0018242", "name": "C0018242#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}}
{"token": ["Substantial", "genetic", "heritability", "is", "found", "for", "CH", ",", "C3715113#ent", "<e1>", ",", "and", "LDL", ",", "with", "somewhat", "lower", "estimates", "for", "C0039902#ent", "<e2>", "."], "h": {"id": "C3715113", "name": "C3715113#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [19, 20]}}
{"token": ["Postheparin", "LPL", "activity", "was", "the", "same", "in", "both", "groups", "of", "men", "and", "did", "not", "correlate", "with", "C3715113#ent", "<e1>", ",", "WHR", ",", "insulin", ",", "or", "plasma", "C0039902#ent", "<e2>", "levels", "."], "h": {"id": "C3715113", "name": "C3715113#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [25, 26]}}
{"token": ["Immunohistochemically", ",", "C0126273#ent", "<e1>", "was", "weakly", "expressed", "in", "vascular", "smooth", "muscle", "cells", "perivascular", "and", "C0719022#ent", "<e2>", "connective", "tissues", "bronchial", "epithelium", "normal", "lung", "tissues"], "h": {"id": "C0126273", "name": "C0126273#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [14, 15]}}
{"token": ["A", "subset", "of", "B", "cells", "expressing", "the", "CD5", "marker", "a", "67", "C1705240#ent", "<e1>", "molecule", ",", "has", "been", "implicated", "in", "the", "pathogenesis", "of", "C0004364#ent", "<e2>"], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [22, 23]}}
{"token": ["This", "\"", "split", "T", "cell", "anergy", "delineated", "C1705240#ent", "<e1>", "from", "other", "pediatric", "infections", "C0004364#ent", "<e2>", "correlated", "with", "CAA", "formation", "(", "P<.001", ")", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "ectopic", "expression", "of", "the", "RhoA-binding", ",", "N-terminal", "domain", "of", "C1413800#ent", "<e1>", "is", "sufficient", "to", "block", "the", "ability", "of", "C1413800#ent", "<e1>", "C0597298#ent", "<e1>", "1", "to", "inhibit", "RhoA", "and", "to", "promote", "invasiveness", "."], "h": {"id": "C1413800", "name": "C1413800#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [22, 23]}}
{"token": ["The", "kinetics", "of", "C1417500#ent", "<e1>", "+", "block", "was", "much", "faster", "for", "C1416556#ent", "<e2>", "than", "for", "ShB", "delta", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416556", "name": "C1416556#ent", "pos": [11, 12]}}
{"token": ["C0917996#ent", "<e1>", "which", "are", "a", "common", "complication", "of", "C0014121#ent", "<e2>", "are", "unusual", "without", "Osler's", "disease"], "h": {"id": "C0917996", "name": "C0917996#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [8, 9]}}
{"token": ["Historical", "and", "current", "literature", "has", "shown", "a", "consistent", "and", "significant", "incidence", "of", "concurrent", "C0917996#ent", "<e1>", "the", "setting", "of", "C0014121#ent", "<e2>"], "h": {"id": "C0917996", "name": "C0917996#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "CHOP", "is", "under", "the", "control", "of", "the", "C1414860#ent", "<e1>", "promoter", "and", "the", "C3274656#ent", "<e2>", "the", "5'-terminal", "part", "of", "C1414860#ent", "<e1>", "which", "provides", "a", "transcriptional", "activation", "function"], "h": {"id": "C3274656", "name": "C3274656#ent", "pos": [14, 15]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1414860", "name": "C1414860#ent", "pos": [9, 10]}}
{"token": ["C0022322#ent", "<e1>", ",", "cyclosporin", "A", "rapamycin", "all", "inhibited", "the", "skeletal", "muscle", "sarcoplasmic", "reticulum", "Ca(2+)-ATPase", "C1706178#ent", "<e2>", ")", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706178", "name": "C1706178#ent", "pos": [14, 15]}}
{"token": ["The", "polymorphisms", "of", "CYP1A1", ",", "C0010763#ent", "<e1>", ",", "GSTM1", ",", "GSTT1", ",", "GSTP1", ",", "mEH", "and", "C0919428#ent", "<e2>", "genes", "were", "analyzed", "by", "PCRjRFLP", "assay", "."], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919428", "name": "C0919428#ent", "pos": [16, 17]}}
{"token": ["This", "will", "be", "illustrated", "by", "four", "genetic", "and", "sporadic", "diseases", "Alzheimer's", "disease", "AD", ")", "and", "related", "disorders", ",", "transthyretin", "dementia", "C0085220#ent", "<e1>", "scrapie", "related", "C0012634#ent", "<e2>", "."], "h": {"id": "C0085220", "name": "C0085220#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["Recent", "studies", "suggest", "that", "C0085220#ent", "<e1>", "plaques", "are", "central", "to", "the", "C0012634#ent", "<e2>"], "h": {"id": "C0085220", "name": "C0085220#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["The", "role", "of", "the", "DNA", "primase", "IncP", "plasmids", "examined", "with", "a", "derivative", "of", "C3151001#ent", "<e1>", "containing", "Tn7", "in", "the", "primase", "gene", "C3539761#ent", "<e2>", ")", "."], "h": {"id": "C3151001", "name": "C3151001#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539761", "name": "C3539761#ent", "pos": [21, 22]}}
{"token": ["Whereas", "the", "unconjugated", "C0031428#ent", "<e1>", "metabolite", "of", "C0075591#ent", "<e2>", "was", "present", "in", "urine", "of", "all", "three", "species", ",", "the", "conjugated", "form", "was", "identified", "only", "in", "dog", "and", "rat", "urines", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0075591", "name": "C0075591#ent", "pos": [7, 8]}}
{"token": ["No", "information", "is", "currently", "available", "on", "the", "quality", "of", "seminal", "tests", "C0020514#ent", "<e1>", "in", "response", "to", "C0107994#ent", "<e2>", "treatment", "."], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0107994", "name": "C0107994#ent", "pos": [16, 17]}}
{"token": ["The", "4", "C0020514#ent", "<e1>", "acromegalics", "were", "treated", "with", "octreotide", "and", "C0107994#ent", "<e2>", "(", "1", "-", "2", "mg/week", ")", "to", "suppress", "PRL", "levels", "."], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0107994", "name": "C0107994#ent", "pos": [10, 11]}}
{"token": ["In", "the", "United", "States", "the", "dopamine", "agonists", "for", "treatment", "of", "C0020514#ent", "<e1>", "are", "bromocriptine", "and", "C0107994#ent", "<e2>", "."], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0107994", "name": "C0107994#ent", "pos": [15, 16]}}
{"token": ["The", "significance", "of", "these", "B-Myb-corepressor", "interactions", "was", "confirmed", "by", "the", "finding", "that", "C0812291#ent", "<e1>", "mutants", ",", "which", "were", "unable", "to", "bind", "C1334870#ent", "<e2>", ",", "exhibited", "constitutive", "transcriptional", "activity"], "h": {"id": "C0812291", "name": "C0812291#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334870", "name": "C1334870#ent", "pos": [21, 22]}}
{"token": ["The", "C0052363#ent", "<e1>", "produced", "was", "derived", "to", "a", "major", "extent", "from", "these", "C3539947#ent", "<e2>", "as", "was", "shown", "by", "comparison", "of", "specific", "activities", "in", "14C-labeling", "experiments", "."], "h": {"id": "C0052363", "name": "C0052363#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "although", "uncommon", ",", "C1333200#ent", "<e1>", "changes", "can", "be", "found", "in", "upper", "motor", "neurons", "some", "C1456383#ent", "<e2>", "cases", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1456383", "name": "C1456383#ent", "pos": [16, 17]}}
{"token": ["The", "ratio", "of", "protein", "O-mannosyl", "beta-1,2-N-acetylglucosaminyltransferase", "1", "activity", "to", "the", "activity", "of", "a", "glycosyltransferase", "control", "N-acetylglucosaminyltransferase", "1", "C3538712#ent", "<e1>", ")", "in", "fibroblasts", "was", "on", "average", "0.006", "in", "C0457133#ent", "<e2>", "patients", "and", "0.045", "in", "controls", "."], "h": {"id": "C3538712", "name": "C3538712#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0457133", "name": "C0457133#ent", "pos": [27, 28]}}
{"token": ["The", "results", "showed", "that", "T", "cells", "PAR-1", ",", "C0812264#ent", "<e1>", "and", "PAR-3", "proteins", "and", "C0017337#ent", "<e2>", "."], "h": {"id": "C0812264", "name": "C0812264#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["Also", "C0241868#ent", "<e1>", "iatrogenic", "injury", "acute", "mesenteric", "ischemia", "lead", "to", "C0000727#ent", "<e2>"], "h": {"id": "C0241868", "name": "C0241868#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000727", "name": "C0000727#ent", "pos": [10, 11]}}
{"token": ["In", "addition", "C2698698#ent", "<e1>", "appears", "to", "be", "associated", "with", "C0003507#ent", "<e2>", "bicuspid", "aortic", "valve", "frequently", "as", "with", "ventricular", "septal", "defect"], "h": {"id": "C2698698", "name": "C2698698#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [9, 10]}}
{"token": ["Twenty-five", "patients", "(", "39", "%", ")", "with", "C2698698#ent", "<e1>", "had", "other", "congenital", "abnormalities", "which", "C0003507#ent", "<e2>", "associated", "with", "bicuspid", "aortic", "valve", "slightly", "more", "common", "than", "ventricular", "septal", "defect", "7:6", ")", "."], "h": {"id": "C2698698", "name": "C2698698#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [14, 15]}}
{"token": ["Studies", "in", "animals", "showed", "that", "both", "C0162758#ent", "<e1>", "SSRIs", ")", "and", "the", "epilepsy", "medication", "C0031507#ent", "<e2>", "(", "dilantin", ")", "block", "the", "effects", "of", "stress", "on", "the", "hippocampus", "."], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [14, 15]}}
{"token": ["Bioinformatic", "analysis", "gene", "expression", "regulated", "by", "C1332109#ent", "<e1>", "implicated", "interleukin-1alpha", "(", "IL-1alpha", ")", "and", "IL-1beta", "as", "key", "C0127400#ent", "<e2>", "of", "amphiregulin's", "biological", "effects"], "h": {"id": "C1332109", "name": "C1332109#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [17, 18]}}
{"token": ["Acetone", "(", "5", "%", ")", "slightly", "enhanced", "the", "N-demethylase", "activity", "the", "liver", "enzyme", "whereas", "5", "%", "C0001002#ent", "<e1>", "completely", "inhibited", "the", "C0014434#ent", "<e2>"], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014434", "name": "C0014434#ent", "pos": [21, 22]}}
{"token": ["Immunofluorescence", "microscopy", "permeabilized", "cells", "revealed", "that", "the", "failure", "to", "express", "mutant", "C1439350#ent", "<e1>", "the", "cell", "surface", "not", "result", "from", "failure", "to", "synthesize", "the", "C1305923#ent", "<e2>", "."], "h": {"id": "C1439350", "name": "C1439350#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [23, 24]}}
{"token": ["The", "presentation", "may", "range", "from", "a", "minor", "C0009763#ent", "<e1>", "resulting", "from", "an", "C0581381#ent", "<e2>", "a", "serious", ",", "debilitating", "epidemic", "keratoconjunctivitis"], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "whether", "tissue", "plasminogen", "activator", "C0078956#ent", "<e1>", ")", "alters", "macrophage", "reactive", "oxygen", "species", "C0289313#ent", "<e2>", ")", "production", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [14, 15]}}
{"token": ["By", "contrast", ",", "the", "TPA-resistant", "U-937", "cell", "variant", "(", "TUR", ")", ",", "which", "is", "deficient", "in", "PKCbetaII", "expression", ",", "failed", "to", "respond", "to", "C0078956#ent", "<e1>", "with", "the", "induction", "of", "C0289313#ent", "<e2>", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [29, 30]}}
{"token": ["The", "present", "studies", "demonstrate", "that", "the", "C0078956#ent", "<e1>", "response", "of", "U-937", "cells", "includes", "the", "generation", "of", "reactive", "oxygen", "species", "C0289313#ent", "<e2>", ")", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [19, 20]}}
{"token": ["Two", "patients", "with", "C0035302#ent", "<e1>", "transient", "atrial", "fibrillation", "and", "one", "had", "patent", "foramen", "ovale", "C0521533#ent", "<e2>"], "h": {"id": "C0035302", "name": "C0035302#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0521533", "name": "C0521533#ent", "pos": [14, 15]}}
{"token": ["Consistent", "with", "previous", "studies", ",", "this", "mutation", "resulted", "in", "at", "least", "3", "-", "4-fold", "decreased", "sensitivity", "to", "the", "C3653457#ent", "<e1>", "carbendazim", "and", "C0028247#ent", "<e2>", "."], "h": {"id": "C3653457", "name": "C3653457#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0028247", "name": "C0028247#ent", "pos": [22, 23]}}
{"token": ["This", "study", "concerns", "the", "C1420554#ent", "<e1>", "expression", "in", "anterior", "horn", "neurons", "of", "15", "patients", "with", "C0002736#ent", "<e2>", "of", "4", "patients", "with", "lower", "motor", "neuron", "disease", "who", "had", "no", "upper", "motor", "neuron", "corticospinal", "tract", "involvement", "."], "h": {"id": "C1420554", "name": "C1420554#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [15, 16]}}
{"token": ["Basic", "pancreatic", "trypsin", ",", "a", "potent", "inhibitor", "of", "chymotrypsin", ",", "had", "similar", "kinetics", "to", "C0055676#ent", "<e1>", "but", "failed", "to", "inhibit", "C0055673#ent", "<e2>", "."], "h": {"id": "C0055676", "name": "C0055676#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [20, 21]}}
{"token": ["They", "have", "been", "shown", "to", "play", "a", "role", "in", "C0600327#ent", "<e1>", "mucocutaneous", "lymph", "node", "syndrome", "are", "postulated", "to", "play", "a", "role", "in", "other", "C0442893#ent", "<e2>"], "h": {"id": "C0600327", "name": "C0600327#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [23, 24]}}
{"token": ["Specific", "binding", "by", "these", "iodinated", "ligands", "stereoselective", "and", "inhibited", "by", "a", "variety", "of", "C0001637#ent", "<e1>", "a", "specificity", "typical", "of", "the", "C1332027#ent", "<e2>"], "h": {"id": "C0001637", "name": "C0001637#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332027", "name": "C1332027#ent", "pos": [20, 21]}}
{"token": ["Recent", "skin-test", "converters", "should", "be", "evaluated", "for", "C0022209#ent", "<e1>", "prophylaxis", "after", "a", "chest", "radiograph", "out", "C0151332#ent", "<e2>"], "h": {"id": "C0022209", "name": "C0022209#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0151332", "name": "C0151332#ent", "pos": [15, 16]}}
{"token": ["Though", "a", "better", "test", "than", "the", "quantitation", "of", "C3", "and", "C4", ",", "the", "value", "of", "C3151071#ent", "<e1>", "determination", "in", "C0035435#ent", "<e2>", "to", "be", "limited", "."], "h": {"id": "C3151071", "name": "C3151071#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [19, 20]}}
{"token": ["The", "results", "suggested", "that", "the", "factors", "of", "interindividual", "variation", "for", "C0054836#ent", "<e1>", "clearance", "were", "creatinine", "clearance", "and", "polymorphisms", "of", "UGT2B7", "and", "C3887685#ent", "<e2>", "in", "the", "Japanese", "population", "with", "heart", "disease"], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [10, 11]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [21, 22]}}
{"token": ["We", "have", "investigated", "the", "proposal", "that", "the", "C3640117#ent", "<e1>", "RAP", ")", "of", "the", "low", "density", "lipoprotein", "receptor-related", "protein/alpha", "2-macroglobulin", "receptor", "binds", "to", "heparan", "sulfate", "proteoglycans", "C0034152#ent", "<e2>", ")", "."], "h": {"id": "C3640117", "name": "C3640117#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [25, 26]}}
{"token": ["The", "mechanism", "of", "inhibitory", "effects", "of", "C0771004#ent", "<e1>", ",", "an", "antiallergic", "and", "antiasthmatic", "agent", "on", "depolarization-", "and", "C2936795#ent", "<e2>", "contractions", "of", "intact", "smooth", "muscle", "studied", "."], "h": {"id": "C0771004", "name": "C0771004#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936795", "name": "C2936795#ent", "pos": [17, 18]}}
{"token": ["We", "report", "the", "cDNA", "sequences", "amino", "acid", "sequences", "the", "beta", "and", "gamma", "subunits", "ABP", "from", "a", "mouse", "cDNA", "library", "identifying", "the", "two", "C0599220#ent", "<e1>", "by", "their", "C3273483#ent", "<e2>", "and", "molecular", "weights"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3273483", "name": "C3273483#ent", "pos": [26, 27]}}
{"token": ["This", "combination", "should", "be", "selected", "for", "studies", "to", "compare", "C0085176#ent", "<e1>", "with", "other", "therapies", "for", "C1535939#ent", "<e2>"], "h": {"id": "C0085176", "name": "C0085176#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [15, 16]}}
{"token": ["To", "evaluate", "the", "in", "vivo", "efficacy", "of", "C0085176#ent", "<e1>", ",", "steroid-treated", "rats", "which", "spontaneously", "develop", "P.", "carinii", "C1535939#ent", "<e2>", "were", "used", "."], "h": {"id": "C0085176", "name": "C0085176#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [17, 18]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "determine", "the", "pharmacokinetics", "of", "C0085176#ent", "<e1>", "and", "dapsone", "in", "AIDS", "patients", "with", "moderate", "to", "severe", "C1535939#ent", "<e2>"], "h": {"id": "C0085176", "name": "C0085176#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [22, 23]}}
{"token": ["We", "are", "presenting", "a", "36-year-old", "male", "patient", "with", "C0423640#ent", "<e1>", "a", "history", "of", "recurrent", "C0042029#ent", "<e2>", "three", "years", "."], "h": {"id": "C0423640", "name": "C0423640#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [14, 15]}}
{"token": ["Dermatologic", "manifestations", "been", "treated", "with", "nonsteroidal", "anti-inflammatory", "agents", "low-dose", "corticosteroids", "C0012403#ent", "<e1>", "and", "edetate", "disodium", "peripheral", "and", "C1096458#ent", "<e2>", "with", "alpha-adrenergic", "blockers", "angiotensin-converting-enzyme", "inhibitors", "and", "calcium-channel", "blockers"], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1096458", "name": "C1096458#ent", "pos": [17, 18]}}
{"token": ["Introduction", "of", "the", "C3540047#ent", "<e1>", "has", "altered", "physician", "prescribing", "practices", "in", "the", "treatment", "of", "C0009450#ent", "<e2>", "both", "inpatients", "and", "outpatients", "."], "h": {"id": "C3540047", "name": "C3540047#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [14, 15]}}
{"token": ["Vibrio", "cholerae", "the", "causative", "agent", "cholera", ",", "expresses", "a", "toxin", "required", "for", "virulence", "consisting", "of", "two", "C0599220#ent", "<e1>", ":", "the", "pentameric", "cholera", "toxin", "B", "CTB", ")", "and", "cholera", "toxin", "A", "C3540513#ent", "<e2>", ")", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540513", "name": "C3540513#ent", "pos": [30, 31]}}
{"token": ["N-terminal", "sequence", "analysis", "the", "two", "largest", "C0599220#ent", "<e1>", "confirmed", "them", "to", "be", "encoded", "by", "the", "cloned", "C3540513#ent", "<e2>"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540513", "name": "C3540513#ent", "pos": [16, 17]}}
{"token": ["The", "phage", "was", "filamentous", "and", "curly", ",", "resistant", "to", "C0035542#ent", "<e1>", "and", "diethyl", "ether", "sensitive", "to", "C0008232#ent", "<e2>", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008232", "name": "C0008232#ent", "pos": [16, 17]}}
{"token": ["The", "increased", "frequency", "of", "C2348925#ent", "<e1>", "and", "5", "recently", "described", "in", "thyroiditis", "with", "transient", "C0271815#ent", "<e2>", "not", "found", "in", "our", "series", "."], "h": {"id": "C2348925", "name": "C2348925#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0271815", "name": "C0271815#ent", "pos": [14, 15]}}
{"token": ["These", "included", "the", "nuclear", "dihydrofolate", "reductase", "gene", "a", "cysteine", "protease", "gene", "mitochondrial", "cytochrome", "b", "C4284184#ent", "<e1>", "and", "the", "C0059037#ent", "<e2>", "caseinolytic", "protease", "C", ",", "and", "\"", "open", "reading", "frame", "470", "genes", "from", "the", "apicoplast", "genome", "for", "a", "combined", "total", "of", "5049", "nucleotides", "."], "h": {"id": "C4284184", "name": "C4284184#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [18, 19]}}
{"token": ["The", "treatment", "of", "ergotism", "with", "C0037533#ent", "<e1>", "reviewed", "and", "the", "apparent", "interaction", "of", "C0014710#ent", "<e2>", "and", "triacetyloleandomycin", "is", "discussed", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014710", "name": "C0014710#ent", "pos": [13, 14]}}
{"token": ["Her", "history", "was", "remarkable", "for", "C0013295#ent", "<e1>", "long-term", "treatment", "with", "a", "C2930042#ent", "<e2>", "Maalox", ")", "and", "sucralfate", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C2930042", "name": "C2930042#ent", "pos": [11, 12]}}
{"token": ["The", "C0026454#ent", "<e1>", "is", "electrogenic", ",", "C2712370#ent", "<e2>", "ion", "currents", "membranes", ",", "induces", "apoptosis", ",", "regulates", "cytokine", "production", "influences", "gene", "expression", "and", "promotes", "formation", "of", "extracellular", "traps"], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [6, 7]}}
{"token": ["Induction", "of", "C1334706#ent", "<e1>", ",", "activation", "of", "C1366894#ent", "<e2>", "of", "PI3-kinase", "are", "implicated", "in", "VEGF-A-induced", "endothelial", "cell", "migration"], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366894", "name": "C1366894#ent", "pos": [7, 8]}}
{"token": ["To", "localize", "the", "determinants", "of", "the", "narrow", "tropism", "of", "the", "C0080279#ent", "<e1>", "we", "generated", "a", "series", "of", "hybrid", "C0035369#ent", "<e2>", "genomes", "containing", "portions", "of", "the", "v-abl", "and", "v-src", "oncogenes", "a", "Moloney", "murine", "leukemia", "virus", "backbone"], "h": {"id": "C0080279", "name": "C0080279#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035369", "name": "C0035369#ent", "pos": [18, 19]}}
{"token": ["In", "the", "same", "experiments", ",", "all", "three", "non-B-cell", "lines", "showed", "NF-kappa", "B", "activation", "C1706544#ent", "<e1>", "upregulation", "but", "never", "any", "effect", "upon", "C1704467#ent", "<e2>", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [21, 22]}}
{"token": ["The", "initial", "symptoms", "were", "focal", "neurological", "deficits", "aphasia", ",", "hemiparesis", ",", "hemianopsia", ")", "because", "of", "intracranial", "haematoma", "four", "patients", ",", "dementia", "in", "two", ",", "C0270697#ent", "<e1>", "in", "one", "and", "C0751559#ent", "<e2>", "one", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0751559", "name": "C0751559#ent", "pos": [29, 30]}}
{"token": ["Cavernous", "sinus", "dural", "arteriovenous", "shunt", "CdAVS", ")", "usually", "presents", "with", "exophthalmos", ",", "conjunctival", "chemosis", "ophthalmoplegia", ",", "C0270697#ent", "<e1>", ",", "bruit", ",", "or", "C0751559#ent", "<e2>"], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0751559", "name": "C0751559#ent", "pos": [22, 23]}}
{"token": ["We", "investigated", "the", "inhibition", "of", "proliferation", "of", "human", "retinal", "pigment", "epithelial", "cells", "in", "vitro", "the", "4-quinolone", ",", "C0008809#ent", "<e1>", ",", "and", "the", "steroid", ",", "C0011777#ent", "<e2>", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [24, 25]}}
{"token": ["Acetaminophen", "(", "C0000970#ent", "<e1>", ")", "is", "normally", "C0025517#ent", "<e2>", "in", "the", "liver", "and", "kidney", "by", "P450", "enzymes", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [7, 8]}}
{"token": ["Kinetic", "studies", "that", "C0000970#ent", "<e1>", "and", "p-nitrophenol", "are", "C0025517#ent", "<e2>", "by", "a", "single", "isozyme", "in", "that", "p-nitrophenol", "was", "found", "to", "be", "a", "competitive", "inhibitor", "of", "C0000970#ent", "<e1>", "glucuronidation", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [8, 9]}}
{"token": ["Interestingly", ",", "EPO", "was", "the", "only", "C0079429#ent", "<e1>", "investigated", "that", "showed", "responsiveness", "only", "to", "C1414334#ent", "<e2>", "knock-down", ",", "as", "observed", "in", "Hep3B", "and", "Kelly", "cells", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414334", "name": "C1414334#ent", "pos": [14, 15]}}
{"token": ["We", "used", "a", "somatic", "cell", "genetic", "approach", "identify", "a", "C0079429#ent", "<e1>", "encoding", "a", "novel", "regulatory", "subunit", "a", "constitutively", "active", "holophosphatase", "complex", "dephosphorylates", "C1414334#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414334", "name": "C1414334#ent", "pos": [22, 23]}}
{"token": ["In", "gel-shift", "assay", "the", "C0034861#ent", "<e1>", "in", "this", "study", "selectively", "bound", "to", "the", "C0080117#ent", "<e2>", "RRE", ")", "region", "of", "HIV-1", "env-specific", "RNA", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0080117", "name": "C0080117#ent", "pos": [13, 14]}}
{"token": ["RhlB", "interacts", "physically", "and", "functionally", "with", "RNase", "E", "polynucleotide", "phosphorylase", "C2984134#ent", "<e1>", ")", ",", "two", "other", "components", "of", "the", "C0672724#ent", "<e2>"], "h": {"id": "C2984134", "name": "C2984134#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0672724", "name": "C0672724#ent", "pos": [19, 20]}}
{"token": ["Whereas", "arylesterase", "activity", "correlated", "with", "HDL", "cholesterol", "HDL-C", ")", "and", "apolipoproteinA-I", "(", ")", "levels", ",", "neither", "arylesterase", "nor", "C0163401#ent", "<e1>", "was", "correlated", "with", "C0023816#ent", "<e2>", "or", "HL", "activity"], "h": {"id": "C0163401", "name": "C0163401#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [23, 24]}}
{"token": ["Exposed", "groups", "slight", "increases", "in", "the", "incidence", "of", "C0032285#ent", "<e1>", ",", "tracheitis", ",", "and", "C0035455#ent", "<e2>", "with", "squamous", "metaplasia", "the", "anterior", "nasal", "cavity"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [14, 15]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "determine", "whether", "a", "chlamydial", "isolate", "recovered", "from", "nasal", "swabs", "swine", "with", "C0032285#ent", "<e1>", "could", "cause", "C0032285#ent", "<e1>", "and", "C0035455#ent", "<e1>", "in", "gnotobiotic", "pigs", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [25, 26]}}
{"token": ["In", "addition", ",", "they", "did", "not", "induce", "C0032285#ent", "<e1>", ",", "tracheitis", ",", "or", "tympanitis", "but", "did", "induce", "C0035455#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [17, 18]}}
{"token": ["Patients", "with", "colon", "cancer", "appear", "to", "be", "prime", "candidates", "for", "studies", "utilizing", "O6-benzylguanine", "to", "deplete", "C1332236#ent", "<e1>", "prior", "to", "therapy", "with", "a", "nitrosourea", ",", "C0077008#ent", "<e2>", ",", "or", "tetrazine", "."], "h": {"id": "C1332236", "name": "C1332236#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0077008", "name": "C0077008#ent", "pos": [24, 25]}}
{"token": ["Adenophostin", "A", "the", "most", "potent", "known", "C2987634#ent", "<e1>", "of", "inositol", "1,4", ",", "C4277587#ent", "<e2>", "(", "InsP(3", ")", ")", "receptors", ",", "stimulated", "(45)Ca(2", "+", ")", "release", "from", "the", "intracellular", "stores", "of", "permeabilized", "hepatocytes", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4277587", "name": "C4277587#ent", "pos": [12, 13]}}
{"token": ["Substitution", "of", "a", "fluorine", "for", "a", "hydrogen", "on", "the", "beta-carbon", "of", "asparagine", "weakens", "the", "ability", "of", "the", "C0030956#ent", "<e1>", "to", "bind", "the", "C1413949#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413949", "name": "C1413949#ent", "pos": [22, 23]}}
{"token": ["No", "cross-linking", "was", "observed", "in", "the", "absence", "of", "a", "cryptic", "sequence", "in", "the", "presence", "of", "a", "competitive", "C0030956#ent", "<e1>", "substrate", "of", "the", "C1413949#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413949", "name": "C1413949#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "calcitonin", "is", "an", "effective", "competitive", "inhibitor", "of", "the", "glycosylation", "of", "a", "known", "C0030956#ent", "<e1>", "substrate", "for", "C1413949#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1413949", "name": "C1413949#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "investigate", "the", "phenotypes", "of", "mice", "lacking", "SENP1", "and", "find", "that", "SENP1(-/-", ")", "embryos", "show", "severe", "C0002871#ent", "<e1>", "from", "deficient", "erythropoietin", "(", "C0357126#ent", "<e2>", ")", "production", "and", "die", "midgestation", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0357126", "name": "C0357126#ent", "pos": [23, 24]}}
{"token": ["Limited", "data", "patients", "with", "C0002871#ent", "<e1>", "associated", "with", "RA", "show", "correction", "of", "C0002871#ent", "<e1>", "after", "C0357126#ent", "<e1>", "treatment", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0357126", "name": "C0357126#ent", "pos": [15, 16]}}
{"token": ["Using", "a", "rat", "model", "of", "septic", "shock", "have", "studied", "the", "effects", "of", "C3887648#ent", "<e1>", "or", "the", "NO", "synthase", "inhibitor", "C0068821#ent", "<e2>", "L-NMMA", ")", "on", "arterial", "pressure", "tissue", "damage", "NO", "production", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0068821", "name": "C0068821#ent", "pos": [19, 20]}}
{"token": ["In", "response", "to", "bolus", "injections", "of", "C3887648#ent", "<e1>", ",", "EDRF", "inhibition", "with", "C0068821#ent", "<e2>", "significantly", "reduced", "coronary", "vasodilation", "P", "<", "0.001", ")", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0068821", "name": "C0068821#ent", "pos": [12, 13]}}
{"token": ["Causes", "of", "childhood", "blindness", "about", "1.5", "million", "worldwide", "with", "5", "million", "visually", "disabled", ")", "include", "xerophthalmia", "(", "350,000", "cases", "annually", ")", ",", "C0339166#ent", "<e1>", "and", "less", "frequently", "seen", "ocular", "diseases", "as", "C0019342#ent", "<e2>", "vernal", "keratoconjunctivitis"], "h": {"id": "C0339166", "name": "C0339166#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0019342", "name": "C0019342#ent", "pos": [31, 32]}}
{"token": ["The", "reactivity", "of", "alpha-chymotrypsin", "toward", "p-nitrophenylacetate", "has", "been", "studied", "in", "C0066373#ent", "<e1>", ",", "dimethylsulfoxide", ",", "formamide", "and", "C0050423#ent", "<e2>", "."], "h": {"id": "C0066373", "name": "C0066373#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0050423", "name": "C0050423#ent", "pos": [17, 18]}}
{"token": ["The", "oviposition", "rate", "for", "females", "C0342895#ent", "<e1>", "on", "a", "C0042749#ent", "<e2>", "pig", "as", "larvae", "was", "reduced", "by", "63.4", "%", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042749", "name": "C0042749#ent", "pos": [9, 10]}}
{"token": ["pipiens", "C0342895#ent", "<e1>", "on", "a", "C0042749#ent", "<e2>", "hamster", "and", "interrupted", "to", "complete", "feeding", "on", "an", "immune", "vs.", "a", "nonimmune", "hamster", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042749", "name": "C0042749#ent", "pos": [5, 6]}}
{"token": ["The", "most", "common", "C0019247#ent", "<e1>", "conditions", "include", "cystic", "fibrosis", "Stargardt", "disease", "age-related", "macular", "degeneration", "adrenoleukodystrophy", ",", "C0039292#ent", "<e2>", "Dubin-Johnson", "syndrome", "progressive", "familial", "intrahepatic", "cholestasis"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039292", "name": "C0039292#ent", "pos": [16, 17]}}
{"token": ["C0019247#ent", "<e1>", "the", "lipid", "metabolism", "severe", "clinical", "phenotypes", ",", "such", "as", "C0039292#ent", "<e2>", "but", "have", "a", "minor", "role", "in", "the", "evaluation", "of", "cardiovascular", "risk", "the", "general", "population"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039292", "name": "C0039292#ent", "pos": [11, 12]}}
{"token": ["The", "positioning", "of", "an", "aromatic", "11", "in", "the", "PR", "C1415483#ent", "<e1>", "appears", "to", "be", "critical", "for", "generating", "C0243192#ent", "<e2>", "or", "antagonistic", "activity"], "h": {"id": "C1415483", "name": "C1415483#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [17, 18]}}
{"token": ["We", "demonstrate", "that", "at", "least", "one", "of", "the", "cutin", "pathway", "C1417679#ent", "<e1>", ",", "which", "encodes", "C1432387#ent", "<e2>", "is", "likely", "to", "be", "directly", "targeted", "by", "WIN1", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1432387", "name": "C1432387#ent", "pos": [15, 16]}}
{"token": ["However", ",", "two", "C1417679#ent", "<e1>", "in", "Arabidopsis", "thaliana", "LACS6", "and", "LACS7", ",", "encode", "C1432387#ent", "<e2>", "LACS", ")", "isozymes", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1432387", "name": "C1432387#ent", "pos": [13, 14]}}
{"token": ["In", "cultures", "containing", "the", "T-cell", "mitogen", "leucoagglutinin", "(", "C1420423#ent", "<e1>", ")", "and", "the", "C0078956#ent", "<e2>", "and", "B-cell", "mitogen", "pokeweed", "mitogen", "(", "PWM", ")", "the", "reactivity", "of", "the", "lymphocytes", "was", "low", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [13, 14]}}
{"token": ["Felodipine", "was", "compared", "with", "C0032912#ent", "<e1>", "in", "patients", "with", "C0085580#ent", "<e2>", "blood", "pressure", "not", "controlled", "by", "a", "beta-blocking", "drug"], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "propranolol", "and", "C0032912#ent", "<e1>", "on", "plasma", "lipoproteins", "patients", "with", "C0085580#ent", "<e2>", "evaluated", "according", "to", "a", "crossover", "protocol", "two", "8-week", "periods", "with", "a", "washout", "of", "4", "to", "6", "weeks", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [12, 13]}}
{"token": ["These", "results", "confirm", "that", "C0032912#ent", "<e1>", "induces", "significant", "alpha", "adrenergic", "blockade", "during", "the", "treatment", "of", "C0085580#ent", "<e2>"], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [15, 16]}}
{"token": ["Inclusion", "body", "myositis", "IBM", ")", "is", "a", "C0026848#ent", "<e1>", "classified", "until", "now", "within", "the", "group", "of", "C0751356#ent", "<e2>", "IIM", ")", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0751356", "name": "C0751356#ent", "pos": [16, 17]}}
{"token": ["Certain", "C0026848#ent", "<e1>", "such", "as", "C0751356#ent", "<e2>", "may", "show", "regional", "variability", ",", "prompting", "consideration", "of", "simultaneous", "biopsy", "of", "more", "than", "1", "muscle", "to", "increase", "the", "likelihood", "of", "diagnosis", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0751356", "name": "C0751356#ent", "pos": [5, 6]}}
{"token": ["CagA", ",", "a", "product", "of", "cytotoxin-associated", "gene", "A", "C1704875#ent", "<e1>", ",", "is", "an", "important", "virulence-related", "antigen", "of", "Helicobacter", "pylori", "C1704665#ent", "<e2>", ")", "."], "h": {"id": "C1704875", "name": "C1704875#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [19, 20]}}
{"token": ["Adhesion", "of", "C0031666#ent", "<e1>", "and", "LGG", "was", "reduced", "by", "C0242301#ent", "<e2>", ",", "autoclaving", "and", "by", "pepsin", "and", "trypsin", "treatments", "suggesting", "that", "the", "bacterial", "protein", "structures", "essential", "for", "their", "adhesion", "."], "h": {"id": "C0031666", "name": "C0031666#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242301", "name": "C0242301#ent", "pos": [9, 10]}}
{"token": ["Autoantibodies", "to", "actin-like", "microfilaments", "specific", "for", "chronic", "active", "hepatitis", "autoantibodies", "to", "microtubules", "occur", "in", "C0021345#ent", "<e1>", "autoantibodies", "to", "intermediate", "filaments", "in", "infectious", "hepatitis", "C0008049#ent", "<e2>", ",", "measles", "and", "mumps", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0008049", "name": "C0008049#ent", "pos": [23, 24]}}
{"token": ["Differences", "between", "gastrointestinal", "and", "cardiovascular", "effects", "of", "traditional", "C0003211#ent", "<e1>", "or", "cyclooxygenase-2", "selective", "inhibitor", "coxib", ")", "are", "affected", "by", "C1254351#ent", "<e2>", ",", "dose", ",", "duration", ",", "outcome", "definition", "and", "patient", "gastrointestinal", "cardiovascular", "risk", "factors"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [19, 20]}}
{"token": ["C0003211#ent", "<e1>", "NSAIDs", ")", "account", "for", "more", "reports", "of", "C1254351#ent", "<e2>", "related", "toxicity", "than", "any", "other", "class", "of", "drugs", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [9, 10]}}
{"token": ["It", "may", "be", "concluded", "that", "C0029456#ent", "<e1>", "a", "feature", "of", "C0036421#ent", "<e2>", "with", "and", "without", "calcinosis", "."], "h": {"id": "C0029456", "name": "C0029456#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [10, 11]}}
{"token": ["A", "93-amino", "acid", "stretch", "of", "Csg1p", "shows", "29", "%", "identity", "with", "the", "C1979844#ent", "<e1>", ",", "6-mannosyltransferase", "encoded", "by", "C1426958#ent", "<e2>", "."], "h": {"id": "C1979844", "name": "C1979844#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1426958", "name": "C1426958#ent", "pos": [18, 19]}}
{"token": ["A", "comparison", "between", "the", "C1416587#ent", "<e1>", "xylem", "parenchyma", "cells", "guard", "cells", "and", "C1333890#ent", "<e2>", "from", "Arabidopsis", "leads", "to", "the", "conclusion", "that", "these", "rectifiers", "form", "subtypes", "within", "one", "class", "of", "ion", "channels"], "h": {"id": "C1416587", "name": "C1416587#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333890", "name": "C1333890#ent", "pos": [12, 13]}}
{"token": ["Here", ",", "we", "report", "the", "chromosomal", "localization", "the", "C0079429#ent", "<e1>", "that", "encodes", "C3273384#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273384", "name": "C3273384#ent", "pos": [12, 13]}}
{"token": ["We", "retrospectively", "evaluated", "the", "effectiveness", "of", "C0040864#ent", "<e1>", "treating", "19", "eyes", "with", "macular", "edema", "to", "C0339505#ent", "<e2>", "BRVO", ")", "."], "h": {"id": "C0040864", "name": "C0040864#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0339505", "name": "C0339505#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "the", "efficacy", "of", "combined", "C0040864#ent", "<e1>", "TA", ")", "injection", "and", "laser", "photocoagulation", "persistent", "macular", "edema", "C0339505#ent", "<e2>", "BRVO", ")", "."], "h": {"id": "C0040864", "name": "C0040864#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0339505", "name": "C0339505#ent", "pos": [17, 18]}}
{"token": ["In", "primary", "neuronal", "culture", "CRH", "was", "protective", "against", "cell", "death", "by", "an", "C0078939#ent", "<e1>", "an", "effect", "that", "was", "blocked", "by", "a", "C0019593#ent", "<e2>", "by", "an", "inhibitor", "of", "cyclic", "AMP-dependent", "protein", "kinase"], "h": {"id": "C0078939", "name": "C0078939#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [21, 22]}}
{"token": ["A", "disintegrin", "and", "C1334706#ent", "<e1>", "with", "thrombospondin", "motifs", "ADAMTS-1", ")", "belongs", "to", "the", "large", "C1314771#ent", "<e2>", "family", "of", "proteins", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1314771", "name": "C1314771#ent", "pos": [14, 15]}}
{"token": ["TIMP-3", "is", "unique", "in", "that", "it", "inhibits", "not", "only", "MMPs", ",", "but", "also", "several", "C1314771#ent", "<e1>", "(", "a", "disintegrin", "and", "C1334706#ent", "<e2>", ")", "and", "ADAMTS", "(", "C1314771#ent", "<e1>", "with", "thrombospondin", "motifs", "metalloproteinases", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1314771", "name": "C1314771#ent", "pos": [14, 15]}}
{"token": ["Although", "the", "Mycobacterium", "fortuitum", "resistant", "to", "nine", "commonly", "used", "C0041296#ent", "<e1>", ",", "it", "was", "found", "to", "be", "sensitive", "to", "C0015021#ent", "<e2>", "and", "capreomycine", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0015021", "name": "C0015021#ent", "pos": [19, 20]}}
{"token": ["The", "clinical", "histories", "the", "cause", "for", "AR", "in", "34", "cases", ":", "11", "rheumatic", ",", "13", "C0014121#ent", "<e1>", "4", "congenital", ",", "4", "associated", "with", "aortic", "aneurysms", "2", "the", "C1414542#ent", "<e2>"], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414542", "name": "C1414542#ent", "pos": [27, 28]}}
{"token": ["The", "pathogenesis", "of", "mitral", "valve", "aneurysm", "generally", "C0014121#ent", "<e1>", "rarely", "congenital", "anomaly", "syphylis", ",", "Aortitis", "syndrome", "or", "C1414542#ent", "<e2>"], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414542", "name": "C1414542#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "test", "the", "hypothesis", "that", "the", "cis-acting", "repression", "domain", "is", "a", "conserved", "feature", "of", "PAX3", "and", "C1335194#ent", "<e1>", "and", "that", "C3274700#ent", "<e2>", "similarly", "."], "h": {"id": "C1335194", "name": "C1335194#ent", "pos": [17, 18]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274700", "name": "C3274700#ent", "pos": [21, 22]}}
{"token": ["A", "randomized", ",", "parallel-group", ",", "open-label", ",", "multicenter", "16-week", "clinical", "trial", "compared", "efficacy", "and", "safety", "of", "C0246689#ent", "<e1>", "monotherapy", "and", "nateglinide", "monotherapy", "in", "C0011860#ent", "<e2>", "patients", "previously", "treated", "with", "diet", "and", "exercise", "."], "h": {"id": "C0246689", "name": "C0246689#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [23, 24]}}
{"token": ["The", "S3", "ribosomal", "protein", "Drosophila", "melanogaster", "various", "C1333237#ent", "<e1>", "activities", ",", "including", "the", "capacity", "to", "incise", "at", "C0140145#ent", "<e2>", "sites", "and", "8-oxo-7,8-dihydroguanine", "(", "8-oxoG", ")", "residues", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [17, 18]}}
{"token": ["The", "omega3", "fatty", "acids", "omega3", "C0015923#ent", "<e1>", ")", ",", "which", "have", "C0003392#ent", "<e2>", "various", "cell", "types", "may", "have", "a", "beneficial", "role", "in", "hypertension", "."], "h": {"id": "C0015923", "name": "C0015923#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [11, 12]}}
{"token": ["No", "amplification", "or", "rearrangement", "of", "the", "three", "C0034677#ent", "<e1>", "detected", "among", "the", "104", "breast", "carcinoma", "C0011522#ent", "<e2>", "tested", "."], "h": {"id": "C0034677", "name": "C0034677#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [15, 16]}}
{"token": ["Based", "on", "reactivity", "of", "the", "C3538729#ent", "<e1>", "gel", "shift", "band", "with", "antibodies", "to", "the", "C1705663#ent", "<e2>", "ref1", ")", "in", "shift", "Western", "experiments", "it", "is", "shown", "that", "the", "37-kD", "component", "represents", "ref1", "."], "h": {"id": "C3538729", "name": "C3538729#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705663", "name": "C1705663#ent", "pos": [14, 15]}}
{"token": ["Mutant", "plants", "a", "T-DNA", "insertion", "in", "C3272448#ent", "<e1>", "as", "well", "as", "transgenic", "plants", "reduced", "C3272448#ent", "<e1>", "mRNA", "levels", "showed", "hyperactivation", "of", "PR-1", "gene", "expression", "after", "C1825840#ent", "<e1>", "treatment", "but", "no", "effect", "the", "disease", "resistance", "phenotype", "."], "h": {"id": "C3272448", "name": "C3272448#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [25, 26]}}
{"token": ["However", ",", "NPM", "could", "be", "functionally", "replaced", "in", "the", "fusion", "protein", "the", "portion", "of", "the", "unrelated", "translocated", "promoter", "region", "C1420877#ent", "<e1>", ")", "protein", "that", "activates", "the", "C0029011#ent", "<e2>", "fusion", "kinase", "mediating", "dimerization", "through", "its", "leucine", "zipper", "motif"], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [19, 20]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0029011", "name": "C0029011#ent", "pos": [26, 27]}}
{"token": ["(br5U)n", "did", "not", "activate", "either", "the", "C0031727#ent", "<e1>", "or", "the", "C1335439#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [10, 11]}}
{"token": ["To", "examine", "the", "species", "barriers", "between", "C1334981#ent", "<e1>", "primates", "and", "humans", ",", "we", "sequenced", "the", "C0079941#ent", "<e2>", "ORF", ")", "of", "25", "PrP", "genes", "from", "apes", "and", "monkeys", "."], "h": {"id": "C1334981", "name": "C1334981#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}}
{"token": ["To", "examine", "the", "species", "barriers", "between", "C1334981#ent", "<e1>", "primates", "and", "humans", ",", "we", "sequenced", "the", "open", "reading", "frames", "C0079941#ent", "<e2>", ")", "of", "25", "PrP", "genes", "from", "apes", "and", "monkeys", "."], "h": {"id": "C1334981", "name": "C1334981#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [18, 19]}}
{"token": ["C0700442#ent", "<e1>", "AD", ")", "is", "a", "very", "effective", "C0003195#ent", "<e2>", "but", "its", "use", "is", "often", "associated", "with", "pulmonary", "complications", "."], "h": {"id": "C0700442", "name": "C0700442#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["C0700442#ent", "<e1>", "a", "new", "C0003195#ent", "<e2>", "has", "been", "associated", "with", "pulmonary", "toxicity", "by", "cough", ",", "dyspnea", "and", "diffuse", "pulmonary", "infiltrates"], "h": {"id": "C0700442", "name": "C0700442#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [4, 5]}}
{"token": ["In", "a", "reconstituted", "in", "vitro", "transcription", "assay", "Tax1", "transactivation", "was", "dependent", "upon", "basal", "transcription", "factors", "TFIIB", ",", "TFIIF", ",", "C0035679#ent", "<e1>", "TFIID", ",", "and", "C1333716#ent", "<e2>", "."], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1333716", "name": "C1333716#ent", "pos": [24, 25]}}
{"token": ["Data", "suggest", "that", "C1420305#ent", "<e1>", "may", "be", "the", "C0027203#ent", "<e2>", "responsible", "for", "cholesteryl", "ester", "secretion", "into", "apolipoprotein", "B-containing", "lipoproteins"], "h": {"id": "C1420305", "name": "C1420305#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["The", "human", "acetyl-CoA", "acetyltransferase", "2", "gene", "C1420305#ent", "<e1>", ",", "codes", "for", "a", "thiolase", ",", "an", "C0027203#ent", "<e2>", "involved", "in", "lipid", "metabolism"], "h": {"id": "C1420305", "name": "C1420305#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["Acyl-CoA", ":", "cholesterol", "acyltransferase-2", "C1420305#ent", "<e1>", ")", ",", "an", "intracellular", "cholesterol", "esterification", "C0027203#ent", "<e2>", "found", "only", "in", "the", "intestine", "and", "liver", ",", "has", "been", "demonstrated", "to", "be", "associated", "with", "hypercholesterolemia", "and", "atherosclerosis", "in", "mice", "."], "h": {"id": "C1420305", "name": "C1420305#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["In", "nonseptic", "sheep", "C3273436#ent", "<e1>", "levels", "decreased", "during", "C3539770#ent", "<e2>", "(", "from", "8.5+/-.6", "pg/mL", "to", "5.9+/-.6", "*", ",", "p<.05", ")", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539770", "name": "C3539770#ent", "pos": [8, 9]}}
{"token": ["A", "reagent", "which", "was", "composed", "of", "pure", "titanium", "powder", "C0728774#ent", "<e1>", "was", "not", "preferable", "because", "its", "form", "was", "a", "C0304402#ent", "<e2>", "."], "h": {"id": "C0728774", "name": "C0728774#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "patients", "with", "hypertension", "showed", "marked", "ACE", "up-regulation", "and", "C1422064#ent", "<e1>", "down-regulation", "in", "both", "hypertensive", "cardiopathy", ",", "particularly", ",", "C4054578#ent", "<e2>"], "h": {"id": "C1422064", "name": "C1422064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4054578", "name": "C4054578#ent", "pos": [21, 22]}}
{"token": ["Diuretic", "responsiveness", "patients", "with", "the", "C0027726#ent", "<e1>", "limited", "by", "C2986972#ent", "<e2>", "Na(+", ")", "reabsorption", "by", "the", "terminal", "nephron"], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2986972", "name": "C2986972#ent", "pos": [9, 10]}}
{"token": ["Infusion", "of", "isolated", "human", "hepatocytes", "improved", "the", "C3641106#ent", "<e1>", "markedly", "decreased", "the", "requirement", "for", "exogenous", "C2732002#ent", "<e2>", "rFVIIa", ")", "to", "approximately", "20", "%", "of", "that", "before", "cell", "transplantation"], "h": {"id": "C3641106", "name": "C3641106#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2732002", "name": "C2732002#ent", "pos": [15, 16]}}
{"token": ["On", "the", "contrary", ",", "the", "intracisternal", "administration", "C0981808#ent", "<e1>", "reduced", "the", "body", "temperature", "the", "same", "degree", "both", "in", "C0015967#ent", "<e2>", "and", "nonfebrile", "rabbits", ",", "but", "C0981808#ent", "<e1>", "i.v", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0981808", "name": "C0981808#ent", "pos": [7, 8]}}
{"token": ["The", "remainder", "of", "the", "radioactivity", "from", "C0030346#ent", "<e1>", "or", "Pronase", "digests", "of", "TR-1", "eluted", ",", "like", "the", "C3539712#ent", "<e2>", "fractions", ",", "in", "the", "salt", "fraction", "Sepharose", "CL-4B"], "h": {"id": "C0030346", "name": "C0030346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539712", "name": "C3539712#ent", "pos": [17, 18]}}
{"token": ["Here", ",", "we", "show", "that", "pro-inflammatory", "cytokines", "induce", "the", "expression", "of", "PRL", "receptors", "pulmonary", "fibroblasts", "allowing", "PRL", "to", "inhibit", "C3273763#ent", "<e1>", "NO", "production", "and", "the", "expression", "of", "the", "C1533698#ent", "<e2>", "iNOS", ")", "."], "h": {"id": "C3273763", "name": "C3273763#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [28, 29]}}
{"token": ["Standard", "deviations", "the", "retention", "indices", "all", "C0815040#ent", "<e1>", "were", "less", "than", "0.035", "C0054666#ent", "<e2>", "for", "46", "C0815040#ent", "<e1>", "less", "than", "0.01", "C0054666#ent", "<e2>"], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054666", "name": "C0054666#ent", "pos": [12, 13]}}
{"token": ["Surprisingly", ",", "in", "the", "absence", "of", "camptothecin", ",", "yeast", "rad52", "mutants", "defective", "in", "the", "repair", "of", "double-stranded", "DNA", "breaks", "nonviable", "when", "top1N726L", "or", "C1458146#ent", "<e1>", "C3889446#ent", "<e2>", "but", "viable", "when", "htop1", "vac", "was", "C3889446#ent", "<e2>", "."], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [25, 26]}}
{"token": ["The", "gene", "for", "the", "A2a", "subtype", "receptor", "for", "the", "C0243051#ent", "<e1>", "adenosine", "falls", "the", "class", "of", "intron", "containing", "C1367690#ent", "<e2>"], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367690", "name": "C1367690#ent", "pos": [18, 19]}}
{"token": ["Modulation", "of", "C0243051#ent", "<e1>", "release", "by", "G-protein-coupled", "receptors", "C1367690#ent", "<e2>", ")", "is", "a", "prominent", "presynaptic", "mechanism", "for", "regulation", "of", "synaptic", "transmission"], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1367690", "name": "C1367690#ent", "pos": [8, 9]}}
{"token": ["C0020807#ent", "<e1>", "a", "rare", "disease", "in", "children", ",", "characterized", "by", "C0162316#ent", "<e2>", "anaemia", "and", "pulmonary", "symptoms"], "h": {"id": "C0020807", "name": "C0020807#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [10, 11]}}
{"token": ["C0075193#ent", "<e1>", ",", "a", "protein", "kinase", "C", "inhibitor", "blocked", "the", "action", "of", "PMA", "on", "C1704947#ent", "<e2>", ",", "but", "it", "had", "no", "effect", "on", "the", "ionomycin-induced", "increase", "in", "C1704947#ent", "<e2>", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [14, 15]}}
{"token": ["Acute", "diabetes", "increased", "aniline", "hydroxylation", "C0010763#ent", "<e1>", "demethylation", ",", "decreased", "pentoxyresorufin", "O-dealkylation", "without", "affecting", "benzo(a)pyrene", "hydroxylation", "C0000644#ent", "<e2>", "kidney", "and", "liver", "microsomes", "."], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000644", "name": "C0000644#ent", "pos": [16, 17]}}
{"token": ["The", "primary", "structure", "ECI", "did", "not", "resemble", "those", "of", "other", "C1667078#ent", "<e1>", "inhibitors", "of", "the", "cystatin", "superfamily", "did", "resemble", "that", "of", "a", "C1420342#ent", "<e2>", "as", "a", "repetitive", "structural", "element", "thyroglobulin", "and", "several", "other", "proteins", "."], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [22, 23]}}
{"token": ["Proteolysis", "of", "Bora", "requires", "the", "C1335227#ent", "<e1>", "kinase", "activity", "is", "mediated", "by", "C3272739#ent", "<e2>", "."], "h": {"id": "C1335227", "name": "C1335227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3272739", "name": "C3272739#ent", "pos": [12, 13]}}
{"token": ["Following", "Cdk1-dependent", "recruitment", ",", "C1335227#ent", "<e1>", "triggers", "hBora", "destruction", "by", "phosphorylating", "a", "recognition", "site", "C3272739#ent", "<e2>", ")", "."], "h": {"id": "C1335227", "name": "C1335227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3272739", "name": "C3272739#ent", "pos": [14, 15]}}
{"token": ["Neutrophil", "elastase", "C1417245#ent", "<e1>", "probably", "play", "an", "important", "role", "in", "the", "development", "of", "C0034067#ent", "<e2>"], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034067", "name": "C0034067#ent", "pos": [13, 14]}}
{"token": ["All", "of", "the", "species", "studied", "have", "the", "capacity", "to", "N-demethylate", "meperidine", "to", "C0069006#ent", "<e1>", "and", "to", "hydrolyze", "meperidine", "and", "C0069006#ent", "<e1>", "to", "their", "respective", "C0815040#ent", "<e1>", "."], "h": {"id": "C0069006", "name": "C0069006#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [24, 25]}}
{"token": ["Both", "C0009079#ent", "<e1>", "and", "fluperlapine", "are", "also", "metabolized", "by", "C3887685#ent", "<e2>", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [1, 2]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "18", "patients", "with", "C0002962#ent", "<e1>", "medical", "therapy", "randomly", "assigned", "to", "3-week", "periods", "of", "C0027302#ent", "<e2>", "(", "160", "mg/day", ")", ",", "diltiazem", "(", "240", "mg/day", ")", "or", "their", "combination", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0027302", "name": "C0027302#ent", "pos": [15, 16]}}
{"token": ["C0024198#ent", "<e1>", "is", "a", "C0004623#ent", "<e2>", "transferred", "by", "tick-bites", "."], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [4, 5]}}
{"token": ["Intrastriatal", "injection", "of", "6-hydroxydopamine", "(", "C0085196#ent", "<e1>", ")", "transiently", "increased", "C0035018#ent", "<e2>", "and", "GFRalpha1", "mRNA", "levels", "in", "the", "substantia", "nigra", "pars", "compacta", "1", "day", "postlesion", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035018", "name": "C0035018#ent", "pos": [10, 11]}}
{"token": ["Our", "purpose", "is", "to", "show", "the", "Multi-Detector", "CT", "(", "MDCT", ")", "findings", "of", "an", "intra-abdominal", "giant", "cystic", "lesion", "midgut", "volvulus", "to", "share", "our", "experience", "with", "giant", "C0024214#ent", "<e1>", "mimicking", "a", "mesenteric", "cyst", "a", "C0746405#ent", "<e2>"], "h": {"id": "C0024214", "name": "C0024214#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0746405", "name": "C0746405#ent", "pos": [33, 34]}}
{"token": ["Treatment", "effects", "C0019605#ent", "<e1>", ",", "galanin", "and", "GAD-67", "mRNA", "were", "studied", "by", "quantitative", "C1335824#ent", "<e2>", "on", "serial", "sections"], "h": {"id": "C0019605", "name": "C0019605#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335824", "name": "C1335824#ent", "pos": [13, 14]}}
{"token": ["C1420015#ent", "<e1>", "represents", "a", "special", "model", "C4025268#ent", "<e2>", "by", "a", "presinusoidal", "portal", "block", "and", "a", "well-preserved", "liver", "parenchyma"], "h": {"id": "C1420015", "name": "C1420015#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4025268", "name": "C4025268#ent", "pos": [6, 7]}}
{"token": ["A", "chronic", "progressive", "form", "of", "C2986643#ent", "<e1>", "may", "resemble", "pure", "C0037019#ent", "<e2>"], "h": {"id": "C2986643", "name": "C2986643#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [10, 11]}}
{"token": ["In", "ALS/BMC/CsA-treated", "mice", ",", "for", "example", ",", "median", "survival", "of", "neonatal", "C3H", "grafts", "46", "days", ",", "with", "adult", "grafts", "C1332416#ent", "<e1>", "22", "days", "on", "C57BL/6", "recipients", "(", "full", "C0024518#ent", "<e2>", "disparity", ")", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [28, 29]}}
{"token": ["Digestion", "of", "seminal", "coagula", "with", "PSA", "releases", "C1705930#ent", "<e1>", "and", "PSA-PCI", "complex", "from", "the", "C0009117#ent", "<e2>", "into", "a", "soluble", "phase", "suggesting", "the", "presence", "of", "active", "C1705930#ent", "<e1>", "within", "the", "C0009117#ent", "<e2>", "."], "h": {"id": "C0009117", "name": "C0009117#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705930", "name": "C1705930#ent", "pos": [7, 8]}}
{"token": ["In", "our", "laboratory", "both", "KCn", "and", "(+)-catechin", "inhibited", "peroxidase-mediated", "C1417964#ent", "<e1>", "activation", "into", "a", "C0036117#ent", "<e2>"], "h": {"id": "C1417964", "name": "C1417964#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [14, 15]}}
{"token": ["We", "report", "a", "rare", "case", "of", "C0001339#ent", "<e1>", "by", "pseudocyst", "formation", ",", "splenic", "vein", "thrombosis", "splenic", "infarction", "and", "C2314994#ent", "<e2>", "which", "resulted", "in", "paraplegia", "."], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2314994", "name": "C2314994#ent", "pos": [18, 19]}}
{"token": ["Three", "agents", "were", "capable", "of", "reversing", "MMC", "resistance", ":", "C2757070#ent", "<e1>", ",", "cyclosporin", "A", ",", "and", "C0042523#ent", "<e2>", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [16, 17]}}
{"token": ["It", "is", "concluded", "that", "C2757070#ent", "<e1>", ",", "but", "not", "C0042523#ent", "<e2>", ",", "can", "be", "used", "to", "differentiate", "the", "two", "mdr", "gene", "products", "in", "the", "mouse", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "report", "that", "the", "human", "MBL-MASP", "complex", "contains", "a", "new", "22", "kDa", "protein", "[", "small", "MBL-associated", "protein", "C1426499#ent", "<e1>", ")", "]", "bound", "to", "C0003993#ent", "<e2>", "."], "h": {"id": "C1426499", "name": "C1426499#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003993", "name": "C0003993#ent", "pos": [24, 25]}}
{"token": ["An", "ultraviolet", "spectrophotometric", "method", "been", "developed", "for", "indirect", "determination", "of", "aspirin", "(", "C0007804#ent", "<e1>", ")", "using", "the", "difference", "between", "C0036079#ent", "<e2>", "free", "salicylic", "acid", "rabbit", "plasma", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036079", "name": "C0036079#ent", "pos": [19, 20]}}
{"token": ["Activated", "lamina", "propria", "T", "cells", "responding", "to", "luminal", "C2697827#ent", "<e1>", "are", "thought", "to", "be", "important", "in", "C1426204#ent", "<e2>", "Crohn's", "disease", "and", "T", "cells", "to", "foreign", "MHC", "products", "are", "also", "important", "in", "intestinal", "graft-vs-host", "disease", "intestinal", "transplant", "."], "h": {"id": "C2697827", "name": "C2697827#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1426204", "name": "C1426204#ent", "pos": [16, 17]}}
{"token": ["Our", "survey", "of", "33", "cases", "with", "C0410174#ent", "<e1>", "revealed", "that", "high", "myopia", "and", "C0029124#ent", "<e2>", "common", "in", "C0410174#ent", "<e1>", "."], "h": {"id": "C0029124", "name": "C0029124#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0410174", "name": "C0410174#ent", "pos": [6, 7]}}
{"token": ["To", "determine", "whether", "anti-GM2", "antibody", "be", "clinically", "indicated", "for", "gastrointestinal", "cancers", "we", "evaluated", "the", "mRNA", "expression", "of", "alpha2,8", "C0037039#ent", "<e1>", ",", "a", "GD3", "synthase", "and", "beta1,4", "N-acetylgalactosaminyltransferase", "C4283926#ent", "<e2>", ",", "a", "GM2/GD2", "synthase", "in", "gastrointestinal", "cancers"], "h": {"id": "C0037039", "name": "C0037039#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4283926", "name": "C4283926#ent", "pos": [27, 28]}}
{"token": ["The", "role", "of", "C0772200#ent", "<e1>", "in", "the", "management", "of", "partial", "C0014544#ent", "<e2>", "of", "patients", "with", "intellectual", "disability", "especially", "emphasized", "since", "C0772200#ent", "<e1>", "has", "a", "low", "side-effect", "profile", "in", "the", "cognitive", "area"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0772200", "name": "C0772200#ent", "pos": [3, 4]}}
{"token": ["C0162449#ent", "<e1>", "(", "EC", "2.7.1.11", "and", "aldolase", "(", "C1850941#ent", "<e2>", "have", "been", "highly", "purified", "from", "Saccharomyces", "cerevisiae", "improved", "protocols", "."], "h": {"id": "C0162449", "name": "C0162449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1850941", "name": "C1850941#ent", "pos": [8, 9]}}
{"token": ["In", "the", "latter", "cell", "line", "C3887675#ent", "<e1>", "induction", "by", "TCDD", "and", "by", "12-O-tetradecanoyl", "phorbol-13-acetate", "C0256103#ent", "<e2>", ")", "has", "been", "compared", "."], "h": {"id": "C3887675", "name": "C3887675#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [14, 15]}}
{"token": ["Up-regulation", "of", "C0256103#ent", "<e1>", "expression", "by", "BDNF", "is", "followed", "by", "the", "induction", "of", "plasminogen", "activator", "inhibitor", "2", "C3887675#ent", "<e2>", ")", ",", "an", "inhibitor", "of", "C0256103#ent", "<e1>", "."], "h": {"id": "C3887675", "name": "C3887675#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [2, 3]}}
{"token": ["The", "only", "exception", "is", "the", "Freiburg", "Documentation", "Centre", "for", "Severe", "C0037274#ent", "<e1>", "which", "is", "attempting", "comprehensive", ",", "country-wide", "documentation", "of", "C0014518#ent", "<e2>", "Lyell's", "syndrome", "and", "Stevens-Johnson", "syndrome"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0014518", "name": "C0014518#ent", "pos": [20, 21]}}
{"token": ["Mutation", "analyses", "that", "the", "binding", "of", "a", "transcription", "factor", "C1417047#ent", "<e1>", "to", "the", "regulatory", "site", "to", "the", "promoter", "activity", "indicating", "that", "C1417047#ent", "<e1>", "is", "involved", "in", "the", "expression", "regulation", "the", "human", "C0297981#ent", "<e1>"], "h": {"id": "C1417047", "name": "C1417047#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0297981", "name": "C0297981#ent", "pos": [31, 32]}}
{"token": ["We", "believe", "that", "the", "C0267988#ent", "<e1>", "prolonged", "the", "C2926735#ent", "<e2>", "of", "renal", "failure"], "h": {"id": "C0267988", "name": "C0267988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [8, 9]}}
{"token": ["The", "C1706542#ent", "<e1>", "has", "been", "described", "as", "a", "C2985420#ent", "<e2>"], "h": {"id": "C1706542", "name": "C1706542#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2985420", "name": "C2985420#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "aspirin", "and", "C0020740#ent", "<e1>", "potentiate", "secretagogue", "stimulated", "C0077923#ent", "<e2>", "dispersed", "human", "peptic", "cells", "this", "might", "be", "an", "additional", "mechanism", "of", "non-steroidal", "anti-inflammatory", "drug", "NSAID", ")", "induced", "gastric", "injury"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0077923", "name": "C0077923#ent", "pos": [10, 11]}}
{"token": ["C0035064#ent", "<e1>", "causing", "accumulation", "of", "endogenous", "C0017860#ent", "<e2>", "(", "DAG", ")", "may", "be", "helpful", "in", "studies", "on", "the", "intracellular", "regulatory", "effects", "on", "the", "mechanisms", "of", "attenuation", "of", "this", "putative", "second", "messenger", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [6, 7]}}
{"token": ["Moreover", ",", "bortezomib", ",", "mainly", "by", "inhibition", "of", "the", "NF-kappaB", "pathway", "has", "a", "C0596326#ent", "<e1>", "administered", "together", "with", "other", "C0013227#ent", "<e2>"], "h": {"id": "C0596326", "name": "C0596326#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [19, 20]}}
{"token": ["Of", "44", "amplifiable", "MSI-H", "Dukes", "B2", "tumors", ",", "70", "%", "harbored", "TGFBR2", ",", "63", "%", "C0812198#ent", "<e1>", "and", "only", "4.5", "%", "C1704933#ent", "<e2>", "mutations", "."], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704933", "name": "C1704933#ent", "pos": [21, 22]}}
{"token": ["In", "this", "regard", ",", "however", ",", "EF", "more", "closely", "resembles", "the", "C0036420#ent", "<e1>", "especially", "morphea", "profunda", "and", "C3897992#ent", "<e2>"], "h": {"id": "C0036420", "name": "C0036420#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C3897992", "name": "C3897992#ent", "pos": [17, 18]}}
{"token": ["In", "MJD", ",", "both", "the", "pons", "and", "the", "cerebellum", "were", "atrophic", ",", "C0740279#ent", "<e1>", "less", "pronounced", "than", "that", "in", "SCA1", "and", "C0752124#ent", "<e2>", "."], "h": {"id": "C0740279", "name": "C0740279#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0752124", "name": "C0752124#ent", "pos": [21, 22]}}
{"token": ["Apomorphine", "or", "C0037239#ent", "<e1>", "treatment", "did", "not", "induce", "significant", "effects", "on", "C1414925#ent", "<e2>", "and", "preproenkephalin", "mRNA", "levels", "in", "striatum", "."], "h": {"id": "C0037239", "name": "C0037239#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414925", "name": "C1414925#ent", "pos": [11, 12]}}
{"token": ["C1368110#ent", "<e1>", "had", "homology", "to", "the", "kinase", "domains", "C1335219#ent", "<e2>", ",", "yeast", "Mss4p", "and", "Fab1p", ",", "and", "a", "new", "Caenorhabditis", "elegans", "protein", "identified", "in", "the", "data", "base"], "h": {"id": "C1368110", "name": "C1368110#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335219", "name": "C1335219#ent", "pos": [8, 9]}}
{"token": ["A", "73-year-old", "man", "developed", "conjunctivitis", ",", "epiphora", ",", "pancytopenia", ",", "C0011603#ent", "<e1>", ",", "and", "a", "C0272249#ent", "<e2>"], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0272249", "name": "C0272249#ent", "pos": [15, 16]}}
{"token": ["C1522575#ent", "<e1>", "VEGF", ")", "plays", "a", "pivotal", "role", "both", "in", "C1332628#ent", "<e2>", "and", "proliferative", "retinopathy"], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332628", "name": "C1332628#ent", "pos": [10, 11]}}
{"token": ["Neither", "Tyr-Pro-N-MePhe-D-Pro-NH2", "nor", "dynorphin", "A(1", "17", ")", "microdialyzed", "into", "the", "C1705981#ent", "<e1>", "produced", "significant", "changes", "in", "C0077025#ent", "<e2>", "."], "h": {"id": "C1705981", "name": "C1705981#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0077025", "name": "C0077025#ent", "pos": [16, 17]}}
{"token": ["Superoxide", "dismutase", "C0007367#ent", "<e1>", "reduced", "the", "mutagenic", "effect", "of", "C0003596#ent", "<e2>", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [9, 10]}}
{"token": ["Because", "the", "syndromes", "of", "apparent", "C0039585#ent", "<e1>", "such", "as", "testicular", "feminization", "Reifenstein's", "Syndrome", "are", "associated", "with", "C0018418#ent", "<e2>", ",", "we", "examined", "skin", "fibroblasts", "cultured", "from", "men", "with", "pubertal", "macromastia", "for", "androgen", "receptor", "defects", "."], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0018418", "name": "C0018418#ent", "pos": [16, 17]}}
{"token": ["Serum", "testosterone", "relieved", "the", "symptoms", "of", "C0039585#ent", "<e1>", "addition", "to", "reducing", "the", "size", "and", "tenderness", "of", "the", "C0018418#ent", "<e2>", "."], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0018418", "name": "C0018418#ent", "pos": [17, 18]}}
{"token": ["A", "12.9", "year-old", "girl", ",", "genotypically", "46", ",", "XY", ",", "and", "considered", "to", "have", "a", "C0039585#ent", "<e1>", "developed", "signs", "of", "virilization", "and", "C0018418#ent", "<e2>", "."], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0018418", "name": "C0018418#ent", "pos": [22, 23]}}
{"token": ["Point", "mutations", "deletions", "in", "the", "androgen", "receptor", "gene", "C0039585#ent", "<e1>", "however", "subjects", "with", "Kennedy's", "disease", "normal", "virilization", "although", "progressive", "C0018418#ent", "<e2>", ",", "testicular", "atrophy", "infertility", "may", "occur", "."], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0018418", "name": "C0018418#ent", "pos": [19, 20]}}
{"token": ["A549", "human", "lung", "alveolar", "cells", "treated", "with", "C1710304#ent", "<e1>", "exhibited", "significantly", "higher", "C1417490#ent", "<e2>", "in", "detergent", "lysates", "compared", "with", "cells", "treated", "with", "vehicle", "alone", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417490", "name": "C1417490#ent", "pos": [12, 13]}}
{"token": ["Exposure", "of", "cells", "to", "proinflammatory", "cytokines", "C1710304#ent", "<e1>", "or", "IFN-gamma", ")", "resulted", "in", "upregulation", "of", "C1417490#ent", "<e2>", ",", "MUC4", ",", "MUC16", ",", "and", "MUC5AC", "gene", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417490", "name": "C1417490#ent", "pos": [15, 16]}}
{"token": ["The", "current", "study", "was", "conducted", "to", "elucidate", "the", "mechanism", "through", "which", "C1710304#ent", "<e1>", "stimulates", "expression", "of", "C1417490#ent", "<e2>", ",", "a", "membrane-tethered", "mucin", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417490", "name": "C1417490#ent", "pos": [16, 17]}}
{"token": ["However", ",", "C1710304#ent", "<e1>", "did", "not", "alter", "C1417490#ent", "<e2>", "transcript", "stability", ",", "implying", "increased", "de", "novo", "transcription", "induced", "by", "the", "cytokine", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417490", "name": "C1417490#ent", "pos": [7, 8]}}
{"token": ["C0020538#ent", "<e1>", "frequent", "in", "liver", "transplant", "recipients", "on", "cyclosporine", "A", "C0751039#ent", "<e2>", ")", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [10, 11]}}
{"token": ["C0020538#ent", "<e1>", "nephrotoxicity", ",", "and", "magnesium", "loss", "common", "side", "effects", "the", "immunosuppressive", "agent", "cyclosporin", "A", "C0751039#ent", "<e2>", ")", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [15, 16]}}
{"token": ["Under", "conditions", "optimal", "for", "JNK", "activation", ",", "C0085752#ent", "<e1>", ",", "vinblastine", ",", "and", "VP-16", "all", "induced", "C0376622#ent", "<e2>", "mRNA", "expression", "in", "KB-3", "cells", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376622", "name": "C0376622#ent", "pos": [16, 17]}}
{"token": ["MRP5", "and", "SMRP", "is", "a", "candidate", "molecule", "for", "acquired", "C0085752#ent", "<e1>", "resistance", "in", "addition", "to", "C0376622#ent", "<e2>", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0376622", "name": "C0376622#ent", "pos": [15, 16]}}
{"token": ["In", "preincubation", "studies", ",", "only", "C3813146#ent", "<e1>", "greatly", "enhanced", "the", "degree", "of", "inhibition", "of", "C4084845#ent", "<e2>", "when", "the", "preincubation", "time", "was", "increased", ",", "but", "inhibition", "of", "MAO-A", "was", "not", "enhanced", "."], "h": {"id": "C3813146", "name": "C3813146#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4084845", "name": "C4084845#ent", "pos": [14, 15]}}
{"token": ["Almost", "all", "C3813553#ent", "<e1>", "mutations", "alter", "the", "number", "of", "cysteine", "residues", "in", "the", "C1367721#ent", "<e2>", "repeats", "in", "the", "extracellular", "domain", "the", "protein", "."], "h": {"id": "C3813553", "name": "C3813553#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [13, 14]}}
{"token": ["The", "ratio", "between", "debrisoquine", "and", "C3887685#ent", "<e1>", "in", "urine", "correlated", "significantly", "with", "the", "rate", "of", "C0700523#ent", "<e2>", "the", "AUCs", "of", "amitriptyline", "and", "10-hydroxyamitriptyline", ",", "but", "not", "with", "that", "of", "amitriptyline", "demethylation", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0700523", "name": "C0700523#ent", "pos": [15, 16]}}
{"token": ["The", "C0678941#ent", "<e1>", "causes", "HD", "encodes", "an", "expanded", "C0032500#ent", "<e2>", ">", "35", "in", "huntingtin", ",", "a", "protein", "of", "unknown", "function", "."], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0032500", "name": "C0032500#ent", "pos": [8, 9]}}
{"token": ["Three", "factors", "have", "now", "been", "identified", "which", "may", "result", "in", "C0472767#ent", "<e1>", "the", "inheritance", "of", "mild", "beta+", "thalassaemia", "mutations", ",", "the", "co-inheritance", "of", "C0002312#ent", "<e2>", "the", "inheritance", "of", "factors", "enhancing", "gamma-globin", "gene", "."], "h": {"id": "C0472767", "name": "C0472767#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002312", "name": "C0002312#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "C1414662#ent", "<e1>", "were", "antagonized", "by", "co-administration", "of", "PLC", ",", "C1259877#ent", "<e2>", "mitogen-associated", "protein", "kinase", "inhibitors", "not", "by", "protein", "kinase", "A", "inhibitor"], "h": {"id": "C1414662", "name": "C1414662#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [12, 13]}}
{"token": ["Generally", ",", "these", "C0243192#ent", "<e1>", "did", "not", "potentiate", "the", "subthreshold", "dose", "of", "C0079245#ent", "<e2>", "(", "0.05", "mg/kg", ")", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079245", "name": "C0079245#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "C1519061#ent", "<e1>", "modulates", "the", "interaction", "of", "hnRNP", "A1", "transportin", "C1823503#ent", "<e2>", "."], "h": {"id": "C1519061", "name": "C1519061#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1823503", "name": "C1823503#ent", "pos": [11, 12]}}
{"token": ["The", "\"", "type", "2", "\"", "C1860425#ent", "<e1>", "fusion", "also", "includes", "C0808900#ent", "<e2>", "exon", "5", "is", "present", "in", "another", "25", "%", "."], "h": {"id": "C1860425", "name": "C1860425#ent", "pos": [5, 6]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808900", "name": "C0808900#ent", "pos": [10, 11]}}
{"token": ["Genes", "up", "regulated", "by", "C1860425#ent", "<e1>", "but", "not", "by", "full-length", "C0808900#ent", "<e2>", "were", "identified", "by", "representational", "difference", "analysis", "RDA", ")", "."], "h": {"id": "C1860425", "name": "C1860425#ent", "pos": [4, 5]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808900", "name": "C0808900#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "interaction", "of", "C1860425#ent", "<e1>", "with", "EWS", "and", "C0808900#ent", "<e2>", "was", "observed", "."], "h": {"id": "C1860425", "name": "C1860425#ent", "pos": [5, 6]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808900", "name": "C0808900#ent", "pos": [10, 11]}}
{"token": ["The", "C0018296#ent", "<e1>", "stimulatory", "activity", "neurofibromin", "was", "also", "inhibited", "by", "arachidonic", "and", "C0028928#ent", "<e2>", "the", "presence", "of", "a", "lipid", "mixture", "representing", "the", "major", "lipid", "components", "the", "cell", "membrane"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [12, 13]}}
{"token": ["The", "withdrawal", "syndrome", "which", "was", "detected", "on", "subject-rated", ",", "staff-rated", "and", "objective", "behavioral", "measures", ",", "was", "characterized", "by", "increased", "C0018681#ent", "<e1>", ",", "sleepiness", "and", "C0948094#ent", "<e2>", "and", "decreased", "alertness", "and", "activeness", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0948094", "name": "C0948094#ent", "pos": [24, 25]}}
{"token": ["Although", "C0033429#ent", "<e1>", "is", "a", "known", "substrate", "and", "inhibitor", "of", "the", "cytochrome", "P450", "4-hydroxylation", "pathway", "C0011082#ent", "<e2>", "(", "CYP2D6", "isozyme", ",", "its", "effects", "on", "other", "hepatic", "mixed-", "function", "oxidative", "isozymes", "not", "been", "extensively", "evaluated", "."], "h": {"id": "C0033429", "name": "C0033429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011082", "name": "C0011082#ent", "pos": [15, 16]}}
{"token": ["The", "patients", "taking", "C0033429#ent", "<e1>", "present", "a", "false", "PM", "status", "of", "C0011082#ent", "<e2>", "."], "h": {"id": "C0033429", "name": "C0033429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011082", "name": "C0011082#ent", "pos": [11, 12]}}
{"token": ["Metabolism", "of", "the", "antiarrhythmic", ",", "C0033429#ent", "<e1>", ",", "cosegregates", "with", "the", "C0011082#ent", "<e2>", "polymorphism", "."], "h": {"id": "C0033429", "name": "C0033429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011082", "name": "C0011082#ent", "pos": [11, 12]}}
{"token": ["The", "drugs", "considered", "were", ":", "testosterone", ",", "mesterolone", ",", "C0010621#ent", "<e1>", ",", "estradiol", ",", "progesterone", "and", "C0009008#ent", "<e2>", "."], "h": {"id": "C0010621", "name": "C0010621#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009008", "name": "C0009008#ent", "pos": [16, 17]}}
{"token": ["C0017237#ent", "<e1>", "that", "required", "C1333909#ent", "<e2>", "+", "and", "GTP", "was", "inhibited", "by", "Ca2+,Ca2", "+", "-calmodulin", "or", "ATP", "."], "h": {"id": "C0017237", "name": "C0017237#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [4, 5]}}
{"token": ["Here", "we", "have", "investigated", "the", "distribution", "of", "the", "main", "MCP-1", "receptors", "C1413188#ent", "<e1>", "and", "CCR2B", "in", "C3888318#ent", "<e2>", "by", "polymerase", "chain", "reaction", "PCR", ")", ",", "immunohistochemistry", "and", "in", "situ", "hybridization"], "h": {"id": "C1413188", "name": "C1413188#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3888318", "name": "C3888318#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "the", "present", "study", "highlights", "the", "major", "role", "played", "by", "MCP-1", "and", "its", "counter-receptor", "C1413188#ent", "<e1>", "in", "the", "pathophysiology", "of", "C3888318#ent", "<e2>", ",", "and", "shows", "that", "the", "CCR2", "receptors", "cell", "specific"], "h": {"id": "C1413188", "name": "C1413188#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3888318", "name": "C3888318#ent", "pos": [22, 23]}}
{"token": ["Previous", "association", "studies", "polymorphisms", "in", "the", "C1334074#ent", "<e1>", "susceptibility", "to", "severe", "C0024530#ent", "<e2>", "phenotypes", "have", "been", "inconclusive", "and", "often", "contradictory", "."], "h": {"id": "C1334074", "name": "C1334074#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}}
{"token": ["Our", "study", "provides", "no", "evidence", "for", "a", "role", "of", "C1334074#ent", "<e1>", "variability", "on", "the", "C0024530#ent", "<e2>", "phenotypes", "studied", "."], "h": {"id": "C1334074", "name": "C1334074#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [14, 15]}}
{"token": ["C0812214#ent", "<e1>", "outperforms", "2hnu-FM", "and", "FM", ",", "while", "C0767150#ent", "<e2>", "has", "a", "better", "axial", "resolution", "at", "NAs", "above", "0.8", "."], "h": {"id": "C0812214", "name": "C0812214#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0767150", "name": "C0767150#ent", "pos": [8, 9]}}
{"token": ["The", "degree", "of", "C2364135#ent", "<e1>", "reported", "was", "not", "significantly", "related", "to", "age", ",", "C0262397#ent", "<e2>", "the", "previous", "three", "days", ",", "previous", "symptoms", ",", "previous", "mammographic", "experience", ",", "or", "outcome", "of", "visit", "."], "h": {"id": "C2364135", "name": "C2364135#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0262397", "name": "C0262397#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "specific", "pesticide", "formulations", ",", "especially", "when", "combined", ",", "can", "increase", "C1538714#ent", "<e1>", "and", "uPAR", "expression", "in", "vitro", "C1414250#ent", "<e2>"], "h": {"id": "C1538714", "name": "C1538714#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414250", "name": "C1414250#ent", "pos": [19, 20]}}
{"token": ["After", "intrathecal", "administration", "C1710304#ent", "<e1>", "in", "adult", "rats", ",", "spontaneous", "hind", "paw", "withdrawal", "behavior", "C0020429#ent", "<e2>", "rapidly", "induced", "(", "approximately", "30", "min", ")", ",", "while", "mechanical", "allodynia", "developed", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [14, 15]}}
{"token": ["Administration", "of", "C3273406#ent", "<e1>", "also", "found", "to", "increase", "the", "cytotoxic", "T", "lymphocyte", "production", "in", "C1862324#ent", "<e2>", "treated", "mice", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1862324", "name": "C1862324#ent", "pos": [14, 15]}}
{"token": ["The", "IC50", "for", "the", "formation", "of", "TXB2", "was", "60", "nM", "and", "for", "C1366767#ent", "<e1>", "90", "nM.", "The", "amounts", "of", "PGE2", ",", "C0058310#ent", "<e2>", "PGD2", "and", "6-keto-", "PGF1", "alpha", "correspondingly", "increased", "."], "h": {"id": "C1366767", "name": "C1366767#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [21, 22]}}
{"token": ["Although", "uncommon", ",", "C0085315#ent", "<e1>", "should", "be", "considered", "in", "the", "differential", "diagnosis", "C0020305#ent", "<e2>", "particularly", "when", "the", "preliminary", "clinical", "work-up", "suggests", "a", "nonimmunologic", "basis", "for", "the", "hydrops", "."], "h": {"id": "C0085315", "name": "C0085315#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [12, 13]}}
{"token": ["Inhibitors", "of", "lipid", "peroxidation", "prevent", "the", "loss", "of", "C0051169#ent", "<e1>", "further", "demonstrating", "a", "direct", "relationship", "between", "C3538941#ent", "<e2>", "lipid", "peroxidation", "and", "degradation", "of", "P-450", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3538941", "name": "C3538941#ent", "pos": [16, 17]}}
{"token": ["These", "data", "provide", "evidence", "that", "C0051169#ent", "<e1>", "involved", "in", "C3538941#ent", "<e2>", "mitochondrial", "lipid", "peroxidation", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538941", "name": "C3538941#ent", "pos": [9, 10]}}
{"token": ["EphB4", "protein", "are", "high", "in", "the", "PC3", "prostate", "cancer", "cell", "line", "several", "folds", "higher", "in", "a", "metastatic", "clone", "C3714948#ent", "<e1>", "(", "PC3", "M", ")", "where", "overexpression", "was", "accompanied", "by", "C3811816#ent", "<e2>"], "h": {"id": "C3714948", "name": "C3714948#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3811816", "name": "C3811816#ent", "pos": [29, 30]}}
{"token": ["To", "uncover", "new", "roles", "for", "C0017978#ent", "<e1>", ",", "we", "studied", "Saccharomyces", "cerevisiae", "C1420390#ent", "<e2>", "-", "100", "cells", ",", "which", "have", "a", "temperature-sensitive", "block", "in", "the", "first", "step", "in", "sphingolipid", "synthesis"], "h": {"id": "C0017978", "name": "C0017978#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420390", "name": "C1420390#ent", "pos": [12, 13]}}
{"token": ["In", "budding", "yeast", "Mec1", "and", "Rad53", "kinases", "(", "C1334043#ent", "<e1>", "to", "mammalian", "ATM/ATR", "and", "C0296594#ent", "<e2>", "respectively", ")", "are", "the", "main", "effectors", "of", "this", "checkpoint", "control"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0296594", "name": "C0296594#ent", "pos": [14, 15]}}
{"token": ["C4085201#ent", "<e1>", "scarcely", "secreted", "these", "C0086376#ent", "<e2>", "in", "this", "experiment", ",", "probably", "because", "they", "were", "cultured", "in", "a", "serum-free", "medium"], "h": {"id": "C4085201", "name": "C4085201#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}}
{"token": ["Hedgehog", "(", "C4085201#ent", "<e1>", ")", "is", "a", "member", "of", "a", "family", "of", "secreted", "C0086376#ent", "<e2>", "that", "direct", "patterning", "at", "multiple", "stages", "both", "Drosophila", "and", "vertebrate", "development"], "h": {"id": "C4085201", "name": "C4085201#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["C0533870#ent", "<e1>", "showed", "a", "marked", "cytostatic", "effect", "both", "BL", "SV2", "and", "BL", "C1704467#ent", "<e2>"], "h": {"id": "C0533870", "name": "C0533870#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "administration", "of", "an", "inhibitor", "of", "phosphatidylinositol", "3-kinase", "LY294002", ")", ",", "thought", "to", "be", "an", "upstream", "activator", "C0812228#ent", "<e1>", ",", "exacerbated", "cortical", "apoptosis", "after", "C0036572#ent", "<e2>", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [25, 26]}}
{"token": ["The", "calcium", "antagonists", "nifedipine", ",", "diltiazem", "and", "C0042523#ent", "<e1>", "partially", "inhibited", "endothelin-induced", "C0032143#ent", "<e2>", "release", ",", "but", "had", "no", "effect", "endothelin-induced", "vWF", "release", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [12, 13]}}
{"token": ["However", ",", "a", "second", "channel", "blocker", "nitrendipine", ",", "proved", "to", "be", "ten", "times", "more", "potent", "than", "C0042523#ent", "<e1>", "and", "totally", "inhibited", "the", "C0032143#ent", "<e2>", "response", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [22, 23]}}
{"token": ["\"", "Myiasis", "\"", "is", "a", "C1384353#ent", "<e1>", "live", "human", "or", "vertebrate", "animal", "tissues", "cavities", "caused", "by", "dipterous", "larvae", "C0027030#ent", "<e2>", ")", "which", "feed", "on", "the", "host", "'s", "dead", "or", "living", "tissue", "liquid", "body", "substances", "ingested", "food", "."], "h": {"id": "C1384353", "name": "C1384353#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027030", "name": "C0027030#ent", "pos": [18, 19]}}
{"token": ["However", ",", "C0162298#ent", "<e1>", "measurements", "showed", "that", "in", "C0424790#ent", "<e2>", "many", "more", "cross-bridges", "are", "attached", "to", "actin", "at", "any", "one", "moment", "than", "in", "contraction", "."], "h": {"id": "C0162298", "name": "C0162298#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0424790", "name": "C0424790#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "C0771315#ent", "<e1>", "is", "a", "potent", "and", "long-acting", "antisecretory", "drug", "patients", "with", "C0043515#ent", "<e2>", "that", "it", "is", "effective", "in", "patients", "whose", "peptic-ulcer", "disease", "relatively", "resistant", "to", "treatment", "with", "histamine", "H2-receptor", "antagonists", "."], "h": {"id": "C0771315", "name": "C0771315#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [14, 15]}}
{"token": ["On", "the", "basis", "of", "these", "results", ",", "SCH56592", "was", "evaluated", "with", "a", "rabbit", "model", "of", "experimental", "C0085436#ent", "<e1>", "SCH56592", "treatment", "was", "compared", "with", "treatment", "with", "C0016277#ent", "<e2>", "."], "h": {"id": "C0085436", "name": "C0085436#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [25, 26]}}
{"token": ["C0085436#ent", "<e1>", "CM", ")", "in", "South", "Africa", "often", "treated", "with", "C0016277#ent", "<e2>", "as", "initial", "therapy", "."], "h": {"id": "C0085436", "name": "C0085436#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [10, 11]}}
{"token": ["In", "order", "to", "understand", "the", "role", "of", "C1416511#ent", "<e1>", "in", "the", "chondrogenic", "differentiation", "in", "more", "detail", ",", "we", "C0907533#ent", "<e2>", "overexpressed", "exogenous", "Itm2A", "in", "mouse", "ATDC5", "cells", "."], "h": {"id": "C1416511", "name": "C1416511#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [18, 19]}}
{"token": ["This", "is", "the", "first", "reported", "case", "of", "C2674616#ent", "<e1>", "associated", "with", "germline", "deletion", "the", "entire", "C0033036#ent", "<e2>"], "h": {"id": "C2674616", "name": "C2674616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "both", "pathologically", "and", "prognostically", ",", "there", "was", "a", "continuous", "spectrum", "'", "pure", "'", "MCD", "(", "MCD-A", ")", "to", "C4049702#ent", "<e1>", "with", "severe", "C0017668#ent", "<e2>"], "h": {"id": "C4049702", "name": "C4049702#ent", "pos": [20, 21]}, "relation": "has_nichd_parent", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [24, 25]}}
{"token": ["Other", "C0035064#ent", "<e1>", ",", "adrenoceptor", "and", "ganglion", "blocking", "C0035064#ent", "<e1>", ",", "C0004259#ent", "<e1>", ",", "reserpine", ",", "tetrodotoxin", "and", "ouabain", ",", "had", "no", "effect", "the", "inhibitory", "action", "suggesting", "the", "existence", "of", "GABA", "receptors", "the", "vascular", "smooth", "muscle", "dog", "cerebral", "arteries"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "C0035064#ent", "<e1>", "such", "as", "reserpine", ",", "propranolol", ",", "phentolamine", ",", "C0004259#ent", "<e2>", "and", "manganese", "ions", "investigated", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [13, 14]}}
{"token": ["This", "was", "abolished", "by", "acute", "preganglionic", "decentralization", "and", "by", "administration", "into", "the", "perfused", "preparation", "of", "alpha-adrenoceptor", "blocking", "C0035064#ent", "<e1>", ",", "but", "not", "of", "C0004259#ent", "<e2>", "or", "diphenhydramine", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [23, 24]}}
{"token": ["This", "MEKC", "method", "could", "provide", "a", "simple", "and", "efficient", "therapeutic", "drug", "monitoring", "method", "C0003299#ent", "<e1>", "especially", "in", "patients", "treated", "with", "combination", "of", "C0078844#ent", "<e2>", "and", "other", "C0003299#ent", "<e1>"], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0078844", "name": "C0078844#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "demonstrate", "a", "new", "pathway", "that", "includes", "the", "induction", "of", "the", "C0026249#ent", "<e1>", "activated", "protein", "kinase", "p38", "by", "C0033634#ent", "<e2>", "results", "in", "a", "specific", "phosphorylation", "of", "c-Jun", "in", "T-lymphocytes", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [19, 20]}}
{"token": ["Recent", "data", "indicate", "that", "C0026249#ent", "<e1>", "increase", "intracellular", "Ca++", "levels", "and", "activate", "C0033634#ent", "<e2>", "inducing", "the", "hydrolysis", "of", "membrane", "phosphoinositides"], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [12, 13]}}
{"token": ["The", "current", "review", "summarizes", "the", "data", "about", "C1418779#ent", "<e1>", "in", "pancreatic", "cancer", "highlights", "the", "biologically", "relevant", "interactions", "between", "the", "C0033551#ent", "<e2>", "and", "PPAR", "system", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [19, 20]}}
{"token": ["C0079225#ent", "<e1>", "commonly", "used", "with", "C0032483#ent", "<e2>", "concentrate", "viruses", "before", "extraction", "of", "their", "DNA", "."], "h": {"id": "C0079225", "name": "C0079225#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [5, 6]}}
{"token": ["These", "included", "SRBC", ",", "dextran", ",", "sucrose", ",", "cellobiose", ",", "polyvinyl", "pyrrolidone", "C0079225#ent", "<e1>", "Ficoll", ",", "and", "C0032483#ent", "<e2>"], "h": {"id": "C0079225", "name": "C0079225#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [17, 18]}}
{"token": ["We", "measured", "single-unit", "responses", "in", "different", "antennal", "sensillae", "C2987364#ent", "<e1>", ",", "clock", "mutant", ",", "odorant-receptor", "mutant", "and", "C0872043#ent", "<e2>", "Gprk2", ")", "mutant", "flies", "examine", "the", "cellular", "and", "molecular", "mechanisms", "drive", "rhythms", "in", "olfaction", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0872043", "name": "C0872043#ent", "pos": [17, 18]}}
{"token": ["The", "higher", "values", "of", "C1858361#ent", "<e1>", "and", "lower", "values", "of", "C0694889#ent", "<e2>", "confirm", "the", "recent", "observations", "of", "others", "."], "h": {"id": "C1858361", "name": "C1858361#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0694889", "name": "C0694889#ent", "pos": [10, 11]}}
{"token": ["The", "amino", "acid", "sequence", "-", "47", "of", "C1539265#ent", "<e1>", "is", "crucial", "for", "HBV", "binding", "to", "human", "C0669372#ent", "<e2>", "as", "well", "as", "to", "PBMC", "and", "haematopoietic", "cell", "lines", "the", "B", "cell", "lineage"], "h": {"id": "C1539265", "name": "C1539265#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}}
{"token": ["C0040613#ent", "<e1>", "valuable", "in", "the", "treatment", "of", "C0038525#ent", "<e2>", "by", "ruptured", "intracranial", "aneurysms"], "h": {"id": "C0040613", "name": "C0040613#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [7, 8]}}
{"token": ["C0026269#ent", "<e1>", "the", "most", "common", "C0018824#ent", "<e2>", "the", "1950s", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [5, 6]}}
{"token": ["In", "turn", ",", "histamine", "enhances", "platelet", "aggregation", "induced", "by", "different", "agonists", ",", "this", "effect", "being", "mimicked", "by", "pyridyl-ethyl-amine", "(", "C0340861#ent", "<e1>", ")", ",", "blocked", "by", "mepyramine", "and", "amplified", "by", "C0034665#ent", "<e2>", "."], "h": {"id": "C0340861", "name": "C0340861#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [29, 30]}}
{"token": ["There", "was", "an", "abnormal", "increase", "of", "5-hydroxyindolacetic", "acid", "the", "cerebrospinal", "fluid", "C0033209#ent", "<e1>", "suggesting", "an", "increase", "of", "the", "turnover", "of", "5-hydroxytryptamine", "during", "C0206085#ent", "<e2>"], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0206085", "name": "C0206085#ent", "pos": [22, 23]}}
{"token": ["Evidence", "is", "also", "presented", "to", "suggest", "a", "possible", "role", "for", "cellular", "polyamines", "the", "TGF-beta(1)-mediated", "alterations", "in", "C1417932#ent", "<e1>", "expression", "in", "C1705572#ent", "<e2>", "transformed", "cells"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [20, 21]}}
{"token": ["The", "bFGF", "regulation", "of", "C1417932#ent", "<e1>", "expression", "in", "C1705572#ent", "<e2>", "transformed", "malignant", "cells", "to", "occur", "independent", "of", "protein", "kinase", "events", "."], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [8, 9]}}
{"token": ["C1421505#ent", "<e1>", "WHS", ")", "caused", "by", "C1956097#ent", "<e2>", "growth", "and", "mental", "retardation", "distinct", "facial", "appearance", "and", "seizures", "."], "h": {"id": "C1421505", "name": "C1421505#ent", "pos": [0, 1]}, "relation": "gene_associated_with_disease", "t": {"id": "C1956097", "name": "C1956097#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", "GD1b", ",", "GT1b", ",", "and", "GQ1b", "may", "enhance", "Th1", "C1333196#ent", "<e1>", "production", "while", "suppressing", "Th2", "production", "by", "inhibiting", "C1382029#ent", "<e2>", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [22, 23]}}
{"token": ["It", "seemed", "that", "the", "swelling", "of", "the", "spinal", "cord", "C0037928#ent", "<e1>", "was", "caused", "by", "C0042344#ent", "<e2>", "spinal", "veins"], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042344", "name": "C0042344#ent", "pos": [14, 15]}}
{"token": ["Unoprostone", "isopropyl", "an", "C0597128#ent", "<e1>", "was", "originally", "produced", "as", "a", "C0058310#ent", "<e2>", "is", "eventually", "recognized", "as", "a", "synthetic", "docosanoid", "."], "h": {"id": "C0597128", "name": "C0597128#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [10, 11]}}
{"token": ["A", "separation", "index", "various", "prodrugs", "was", "calculated", "from", "the", "ratio", "of", "the", "bioavailable", "C0058310#ent", "<e1>", "for", "C0597128#ent", "<e2>", "the", "bioavailable", "C0058310#ent", "<e1>", "for", "hyperemia", "."], "h": {"id": "C0597128", "name": "C0597128#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [13, 14]}}
{"token": ["The", "purpose", "of", "this", "study", "is", "to", "evaluate", "the", "effect", "of", "the", "PGF2alpha", "isopropyl", "ester", "analogue", "Latanoprost", "which", "is", "a", "new", "C0597128#ent", "<e1>", "on", "the", "aqueous", "humor", "C0058310#ent", "<e2>", "levels", "in", "open-angle", "glaucoma", "patients", "."], "h": {"id": "C0597128", "name": "C0597128#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [27, 28]}}
{"token": ["On", "the", "other", "hand", ",", "unlike", "the", "former", ",", "EFNB1R", "costimulation", "failed", "to", "activate", "C0164786#ent", "<e1>", ",", "which", "is", "essential", "in", "triggering", "C1522405#ent", "<e2>", "production", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [22, 23]}}
{"token": ["Mitochondrial", "DNA", "depletion", "seen", "in", "Navajo", "neurohepatopathy", "in", "C0035242#ent", "<e1>", "infancy", "was", "associated", "with", "C0008370#ent", "<e2>", "and", "cirrhosis", "in", "the", "former", "and", "microvesicular", "steatosis", "oncocytic", "transformation", "mitochondrial", "hyperplasia", "in", "the", "latter", "."], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008370", "name": "C0008370#ent", "pos": [14, 15]}}
{"token": ["Non-interacting", "primary", "beam", "particles", "and", "fragments", "have", "been", "identified", "and", "their", "C0622160#ent", "<e1>", "calculated", "by", "measuring", "C0015672#ent", "<e2>", "a", "stack", "of", "silicon", "detectors"], "h": {"id": "C0622160", "name": "C0622160#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015672", "name": "C0015672#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "to", "its", "known", "coenzymatic", "properties", "dihydrolipoic", "acid", "act", "as", "a", "substitute", "for", "coenzyme", "A", "thereby", "diminishing", "the", "C1421313#ent", "<e1>", "efficiency", "of", "C0028928#ent", "<e2>", "."], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [23, 24]}}
{"token": ["Based", "on", "clinical", "and", "pathophysiological", "parameters", ",", "the", "cause", "of", "the", "C0342191#ent", "<e1>", "suspected", "to", "be", "a", "defect", "in", "the", "synthesis", "of", "C1420709#ent", "<e2>", ",", "the", "matrix", "protein", "thyroid", "hormone", "synthesis", "in", "the", "thyroid", "gland"], "h": {"id": "C0342191", "name": "C0342191#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [22, 23]}}
{"token": ["The", "results", "demonstrate", "that", "short-course", "treatment", "with", "dapsone", "plus", "either", "C0008241#ent", "<e1>", "or", "chlorproguanil", "is", "ineffective", "for", "the", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "in", "Thailand", "."], "h": {"id": "C0008241", "name": "C0008241#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [20, 21]}}
{"token": ["The", "results", "demonstrate", "that", "short-course", "treatment", "with", "dapsone", "plus", "either", "proguanil", "or", "C0008241#ent", "<e1>", "is", "ineffective", "for", "the", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "in", "Thailand", "."], "h": {"id": "C0008241", "name": "C0008241#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [20, 21]}}
{"token": ["No", "cross-reactivity", "was", "noted", "with", "sera", "from", "patients", "with", "rheumatoid", "arthritis", "filariasis", ",", "C0013370#ent", "<e1>", ",", "schistosomiasis", ",", "dengue", ",", "scrub", "typhus", "leptospirosis", ",", "or", "C0040558#ent", "<e2>", "."], "h": {"id": "C0013370", "name": "C0013370#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040558", "name": "C0040558#ent", "pos": [25, 26]}}
{"token": ["A", "31-year-old", "man", "with", "rheumatoid", "arthritis", "who", "had", "previously", "been", "treated", "with", "sulindac", ",", "fenoprofen", "calcium", "high", "dose", "salicylates", "and", "gold", "salts", "developed", "C4054747#ent", "<e1>", "RPN", ")", "4", "months", "after", "institution", "of", "C0027396#ent", "<e2>"], "h": {"id": "C4054747", "name": "C4054747#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [32, 33]}}
{"token": ["Gel-filtration", "and", "NMR", "experiments", "demonstrated", "a", "1:1", "complex", "between", "PINCH", "C1417170#ent", "<e1>", "and", "the", "ankyrin", "repeat", "domain", "C1334128#ent", "<e2>", "."], "h": {"id": "C1417170", "name": "C1417170#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334128", "name": "C1334128#ent", "pos": [17, 18]}}
{"token": ["The", "response", "to", "C3539185#ent", "<e1>", "demonstrates", "that", "the", "C3815497#ent", "<e2>", "is", "amenable", "to", "therapy", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3815497", "name": "C3815497#ent", "pos": [8, 9]}}
{"token": ["The", "C0024141#ent", "<e1>", "and", "lupus", "anticoagulant", "were", "treated", "with", "systemic", "steroids", "C0032950#ent", "<e2>", ")", "and", "anticoagulation", "(", "warfarin", ")", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [11, 12]}}
{"token": ["The", "expression", "of", "PPAR", "target", "C0017337#ent", "<e1>", "changed", "in", "a", "cyclical", "manner", "that", "followed", "expression", "of", "C3889970#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889970", "name": "C3889970#ent", "pos": [16, 17]}}
{"token": ["Additionally", ",", "we", "studied", "the", "effects", "of", "C0054201#ent", "<e1>", "on", "terfenadine", "and", "ipratropium", "bromide", "on", "serum", "levels", "interleukin-8", "(", "C1366571#ent", "<e2>", ")", "and", "histamine", "."], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [19, 20]}}
{"token": ["C0007785#ent", "<e1>", "as", "revealed", "by", "C3813556#ent", "<e2>", ",", "may", "be", "more", "prevalent", "in", "\"", "complicated", "\"", "migraine", "than", "is", "generally", "appreciated", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [5, 6]}}
{"token": ["Areas", "of", "C0007785#ent", "<e1>", "noted", "on", "C3813556#ent", "<e2>", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [6, 7]}}
{"token": ["This", "contig", "will", "provide", "a", "primary", "resource", "for", "the", "construction", "of", "a", "transcriptional", "map", "this", "region", "and", "for", "the", "identification", "of", "the", "defective", "C0079429#ent", "<e1>", "causing", "this", "form", "of", "C1412234#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1412234", "name": "C1412234#ent", "pos": [29, 30]}}
{"token": ["To", "determine", "the", "genomic", "organization", "diacylglycerol", "kinase(iota", "and", "to", "test", "whether", "defects", "in", "this", "C0079429#ent", "<e1>", "are", "present", "in", "individuals", "affected", "with", "autosomal", "dominant", "retinitis", "pigmentosa", "C1412234#ent", "<e2>", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412234", "name": "C1412234#ent", "pos": [26, 27]}}
{"token": ["Hypoxic", "neuroblastoma", "cells", "expression", "of", "some", "neuronal", "differentiation", "markers", ",", "and", "forced", "expression", "of", "C3542399#ent", "<e1>", "in", "hypoxic", "neuroblastoma", "cells", "C1333565#ent", "<e2>", "and", "prevents", "the", "loss", "of", "these", "markers", "."], "h": {"id": "C3542399", "name": "C3542399#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333565", "name": "C1333565#ent", "pos": [20, 21]}}
{"token": ["Together", ",", "these", "data", "suggest", "that", "C0381246#ent", "<e1>", "blocks", "embryonic", "hematopoiesis", "the", "stem-progenitor", "cell", "and", "that", "C1332671#ent", "<e2>", "is", "essential", "for", "the", "generation", "of", "hematopoietic", "stem", "progenitor", "cells"], "h": {"id": "C0381246", "name": "C0381246#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1332671", "name": "C1332671#ent", "pos": [16, 17]}}
{"token": ["We", "believe", "that", "our", "results", "may", "provide", "clues", "to", "the", "association", "of", "C1421313#ent", "<e1>", "the", "risk", "of", "C0003850#ent", "<e2>", "through", "their", "effects", "on", "HDL", "cholesterol"], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [17, 18]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "the", "prevalence", "of", "C0162820#ent", "<e1>", "air", "exposed", "C0950252#ent", "<e2>", "among", "dermatitis", "patients", "."], "h": {"id": "C0162820", "name": "C0162820#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0950252", "name": "C0950252#ent", "pos": [16, 17]}}
{"token": ["Rearrangements", "involving", "C0017337#ent", "<e1>", "of", "the", "alpha-", "and", "C2827561#ent", "<e2>", "frequently", "detected", "in", "DNA", "from", "Polynesians", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2827561", "name": "C2827561#ent", "pos": [8, 9]}}
{"token": ["The", "single", "gamma-globin", "gene", "the", "New", "World", "spider", "monkey", "Ateles", "geoffroyi", "similar", "to", "other", "primate", "C0017337#ent", "<e1>", "of", "the", "C2827561#ent", "<e2>", "\"", "beta-like", "\"", "globin", "genes", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2827561", "name": "C2827561#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "from", "this", "that", "the", "epsilon-globin", "gene", "not", "regulated", "by", "competition", "with", "other", "C0017337#ent", "<e1>", "in", "the", "human", "C2827561#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2827561", "name": "C2827561#ent", "pos": [19, 20]}}
{"token": ["The", "C0085292#ent", "<e1>", "involved", "include", "ubiquitin", ",", "HSP70", ",", "C1415764#ent", "<e2>", ",", "and", "HSP25", "."], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415764", "name": "C1415764#ent", "pos": [9, 10]}}
{"token": ["C2916905#ent", "<e1>", "NOSAC", ")", ",", "such", "as", "aspirin", "and", "C0021246#ent", "<e2>", ",", "greatly", "reduce", "the", "PG", "biosynthesis", "and", "cause", "mucosal", "damage", "mucosal", "erosions", "haemorrhages", "observed", "at", "endoscopy", ",", "increased", "gastric", "microbleeding", "DNA", "loss"], "h": {"id": "C2916905", "name": "C2916905#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [9, 10]}}
{"token": ["In", "addition", "to", "C1705543#ent", "<e1>", "being", "coincident", "with", "the", "interaction", "domain", "C1337090#ent", "<e2>", ",", "we", "demonstrate", "a", "novel", "in", "vivo", "interaction", "between", "the", "C1705543#ent", "<e1>", "and", "GCN5", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1337090", "name": "C1337090#ent", "pos": [11, 12]}}
{"token": ["To", "report", "a", "case", "of", "C0010043#ent", "<e1>", "perforation", "after", "PRK", "connected", "with", "high", "doses", "C0064326#ent", "<e2>", "Acula", ")", "."], "h": {"id": "C0010043", "name": "C0010043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0064326", "name": "C0064326#ent", "pos": [14, 15]}}
{"token": ["The", "mRNA", "levels", "of", "C0813143#ent", "<e1>", "and", "GDNFR-alpha", "were", "studied", "in", "the", "spinal", "cord", "patients", "with", "C1862939#ent", "<e2>", "ALS", ")", "by", "reverse", "transcription", "by", "polymerase", "chain", "reaction", "RT-PCR", ")", "and", "in", "situ", "hybridization", "ISH", ")", "."], "h": {"id": "C0813143", "name": "C0813143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1862939", "name": "C1862939#ent", "pos": [16, 17]}}
{"token": ["Importantly", ",", "C1336768#ent", "<e1>", "not", "be", "substituted", "by", "Escherichia", "coli", "C1336659#ent", "<e2>", ",", "and", "the", "Holliday", "junction", "activity", "of", "BLM-related", "helicases", "WRN", "and", "RecQ", "is", "likewise", "impervious", "to", "C1336768#ent", "<e1>", "BLAP75", "."], "h": {"id": "C1336768", "name": "C1336768#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1336659", "name": "C1336659#ent", "pos": [10, 11]}}
{"token": ["C1709313#ent", "<e1>", "interacts", "directly", "with", "the", "Runt", "domain", "C1419772#ent", "<e2>", "but", "does", "not", "interfere", "with", "CBFbeta-RUNX3", "interactions", "."], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419772", "name": "C1419772#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "sulfated", "cholecystokinin", "octapeptide", "C0289932#ent", "<e1>", ")", "and", "C0289932#ent", "<e1>", "antagonist", ",", "C0033321#ent", "<e1>", ",", "given", "intrathecally", "(", "i.t", ".", ")"], "h": {"id": "C0289932", "name": "C0289932#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033321", "name": "C0033321#ent", "pos": [14, 15]}}
{"token": ["The", "small", "dose", "10", "mug", "x", "5", ")", "of", "pulses", "of", "C1705356#ent", "<e1>", "was", "utilized", "in", "the", "assessment", "of", "C2936882#ent", "<e2>", "and", "clomiphene", "treatments", "on", "the", "functional", "capacity", "of", "the", "gonadotrophs", "in", "normal", "men"], "h": {"id": "C1705356", "name": "C1705356#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [19, 20]}}
{"token": ["Patients", "with", "C0026705#ent", "<e1>", "have", "a", "characteristic", "facies", "including", "C0005745#ent", "<e2>", ",", "antimongoloid", "slant", "the", "palpebral", "fissures", "hypertelorism", ",", "micrognathia", ",", "neck", "pterygia", "and", "a", "sad", "flat", ",", "emotionless", "look", "to", "the", "face", "."], "h": {"id": "C0026705", "name": "C0026705#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "rapid", "cleavage", "of", "C1417006#ent", "<e1>", "to", "small", "C0030956#ent", "<e2>", "is", "probably", "necessary", "in", "vivo", "prevent", "the", "aggregation", "of", "larger", "cleavage", "fragments", "."], "h": {"id": "C1417006", "name": "C1417006#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}}
{"token": ["At", "birth", ",", "C1417006#ent", "<e1>", "was", "represented", "by", "the", "smaller", "of", "two", "Mr", "280,000", "C0030956#ent", "<e2>", "(", "MAP2b", ")", "and", "three", "antigenically", "related", "Mr", "70,000", "C0030956#ent", "<e2>", "."], "h": {"id": "C1417006", "name": "C1417006#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}}
{"token": ["C2", ",", "C6", ",", "and", "C1367714#ent", "<e1>", "were", "measured", "by", "hemolytic", "assay", "C1824728#ent", "<e2>", "IgG", "were", "measured", "by", "radial", "immunodiffusion", "samples", "of", "normal", "and", "inflamed", "aqueous", "humor", "."], "h": {"id": "C1367714", "name": "C1367714#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1824728", "name": "C1824728#ent", "pos": [12, 13]}}
{"token": ["In", "the", "case", "that", "developed", "C0032290#ent", "<e1>", "ARDS", "at", "the", "second", "postoperative", "day", ",", "the", "measured", "C1705750#ent", "<e2>", "level", "was", "less", "than", "half", "the", "predicted", "value", "."], "h": {"id": "C0032290", "name": "C0032290#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705750", "name": "C1705750#ent", "pos": [16, 17]}}
{"token": ["The", "highest", "risk", "of", "recurrences", "was", "associated", "with", "elevated", "fibrinolytic", "activity", "the", "cerebrospinal", "fluid", "C3812627#ent", "<e1>", "of", "the", "cerebral", "vessels", "C0751003#ent", "<e2>", "of", "the", "anterior", "connective", "and", "internal", "carotid", "arteries", "well", "as", "the", "patients", "'", "grave", "condition", "."], "h": {"id": "C3812627", "name": "C3812627#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [20, 21]}}
{"token": ["Preparative", "isoelectrofocusing", "IEF", ")", "of", "concentrated", "supernatants", "resolved", "each", "lymphokine", "in", "a", "separate", "peak", ",", "with", "apparent", "C3273482#ent", "<e1>", "of", "5.2", "for", "C1522575#ent", "<e2>", "and", "7.5", "-", "10.1", "for", "IL-2", "."], "h": {"id": "C3273482", "name": "C3273482#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [22, 23]}}
{"token": ["A", "57-year-old", "black", "female", "with", "a", "1-month", "of", "C0235527#ent", "<e1>", "clinical", "evidence", "pulmonic", "and", "C0040963#ent", "<e2>", "insufficiency", "."], "h": {"id": "C0235527", "name": "C0235527#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040963", "name": "C0040963#ent", "pos": [14, 15]}}
{"token": ["The", "increased", "chemotactic", "activity", "C0006266#ent", "<e1>", "were", "blocked", "by", "administration", "of", "C0012694#ent", "<e2>", "to", "antigen", "challenge"], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [11, 12]}}
{"token": ["The", "level", "of", "C1421046#ent", "<e1>", "expression", "in", "the", "C0017363#ent", "<e2>", "significantly", "higher", "than", "all", "the", "control", "groups", "both", "the", "CD4+", "CD8+", "T", "lymphocyte", "."], "h": {"id": "C1421046", "name": "C1421046#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [8, 9]}}
{"token": ["Introduction", "of", "base", "analogues", "single", "sites", "in", "C0720523#ent", "<e1>", "junctions", "has", "allowed", "investigation", "of", "the", "sequence", "specificity", "C2984140#ent", "<e2>", "in", "finer", "detail", "."], "h": {"id": "C0720523", "name": "C0720523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2984140", "name": "C2984140#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "report", "that", "activation", "of", "Rap1", "by", "forskolin", "and", "cAMP", "occurs", "independently", "of", "C0033640#ent", "<e1>", "also", "known", "as", "C2350345#ent", "<e2>", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [19, 20]}}
{"token": ["Discovery", "of", "the", "novel", "fusion", "gene", "C1540912#ent", "<e1>", "FIPILI-PFGFRA", ",", "whose", "product", "is", "an", "imatinib", "sensitive", "C0033640#ent", "<e2>", "permitted", "to", "treat", "successfully", "this", "event", "."], "h": {"id": "C1540912", "name": "C1540912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [16, 17]}}
{"token": ["Third", "generation", "thrombolytic", "agents", "reteplase", ",", "tenecteplase", "and", "C0906021#ent", "<e1>", ")", "are", "variants", "of", "C0078956#ent", "<e2>", "engineered", "to", "have", "improved", "structure/function", ",", "such", "as", "longer", "half", "life", "resistance", "to", "inhibitors", "."], "h": {"id": "C0906021", "name": "C0906021#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [14, 15]}}
{"token": ["A", "good", "linear", "correlation", "observed", "for", "the", "inhibitory", "effect", "of", "angiotensin-converting", "enzyme", "inhibitors", "C0105523#ent", "<e1>", ",", "cilazaprilat", ",", "delaprilat", "and", "C0014025#ent", "<e2>", ")", "between", "isolated", "hepatocytes", "and", "oatp1-expressing", "cells", "."], "h": {"id": "C0105523", "name": "C0105523#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [20, 21]}}
{"token": ["However", ",", "there", "is", "considerable", "variation", "within", "and", "between", "drugs", ",", "with", "C0105523#ent", "<e1>", "and", "benazeprilat", "reaching", "peak", "concentrations", "early", "and", "C0014025#ent", "<e2>", "and", "enalaprilat", "typical", "of", "later", "times", "to", "peak", "."], "h": {"id": "C0105523", "name": "C0105523#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [21, 22]}}
{"token": ["Renal", "injury", "no", "significant", "influence", "on", "the", "overall", "effect", "of", "C0105523#ent", "<e1>", ",", "whereas", "the", "inhibition", "effect", "of", "C0014025#ent", "<e2>", "was", "significantly", "increased", "."], "h": {"id": "C0105523", "name": "C0105523#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [18, 19]}}
{"token": ["This", "study", "examined", "the", "roles", "of", "C1705556#ent", "<e1>", "and", "NaK", "ATPase", "this", "in", "vitro", "model", "of", "the", "Fanconi", "syndrome", "C2931187#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2931187", "name": "C2931187#ent", "pos": [19, 20]}}
{"token": ["The", "C0014442#ent", "<e1>", "consists", "of", "an", "amino-terminal", "regulatory", "domain", "and", "a", "C1416810#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416810", "name": "C1416810#ent", "pos": [11, 12]}}
{"token": ["Certain", "prostaglandins", "are", "likely", "to", "be", "beneficial", "in", "the", "treatment", "of", "gastric", "ulcers", "stress", "ulcers", "C0013295#ent", "<e1>", "and", "perhaps", "gastritis", "and", "certain", "forms", "of", "C0021390#ent", "<e2>"], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [24, 25]}}
{"token": ["The", "prolyl", "hydroxylase", "domain", "1", "PHD1", ")", "isoform", "of", "the", "C3658213#ent", "<e1>", "expressed", "in", "early", "adipogenesis", "and", "the", "PHD2", "and", "C1422820#ent", "<e2>", "isoforms", "are", "expressed", "during", "late", "adipogenesis", "."], "h": {"id": "C3658213", "name": "C3658213#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1422820", "name": "C1422820#ent", "pos": [20, 21]}}
{"token": ["Systemic", "impairment", "C0017789#ent", "<e1>", "uptake", "in", "DS", "is", "suggested", ",", "probably", "related", "to", "C1364818#ent", "<e2>", "overexpression", "and", "mitochondrial", "dysfunction"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [13, 14]}}
{"token": ["A", "novel", "signaling", "system", "can", "interact", "with", "both", "C0017789#ent", "<e1>", "and", "neurotrophic", "factor", "systems", "that", "of", "the", "C1364818#ent", "<e2>", "which", "appears", "to", "play", "important", "roles", "in", "neuronal", "plasticity", "and", "survival", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [17, 18]}}
{"token": ["C0146953#ent", "<e1>", "detergent", "separation", "was", "used", "to", "enrich", "C0051169#ent", "<e2>", "P-450", ")", "and", "other", "integral", "membrane", "proteins", "pulmonary", "microsomes", "and", "these", "were", "directly", "compared", "with", "corresponding", "polypeptides", "from", "hepatic", "microsomes"], "h": {"id": "C0146953", "name": "C0146953#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [8, 9]}}
{"token": ["This", "report", "describes", "a", "fatal", "case", "of", "Bacillus", "cereus", "septicemia", "a", "patient", "with", "uncontrolled", "C0011847#ent", "<e1>", "and", "re-emphasizes", "the", "potential", "seriousness", "of", "C0001249#ent", "<e2>", "patients", "with", "compromised", "immune", "function"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001249", "name": "C0001249#ent", "pos": [22, 23]}}
{"token": ["We", "conclude", "that", "the", "NSAID", "lysine", "C0009018#ent", "<e1>", "is", "effective", "in", "treating", "moderately", "severe", "C0154723#ent", "<e2>", "attacks", "."], "h": {"id": "C0009018", "name": "C0009018#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0154723", "name": "C0154723#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "with", "C0669516#ent", "<e1>", "SOD", ")", "protected", "cells", "against", "C3541303#ent", "<e2>", "virus-induced", "apoptosis"], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541303", "name": "C3541303#ent", "pos": [9, 10]}}
{"token": ["The", "C0897757#ent", "<e1>", "of", "membrane-associated", "cytochrome", "b558", "and", "cytosolic", "components", "C1417608#ent", "<e2>", "and", "p67-phox", "."], "h": {"id": "C0897757", "name": "C0897757#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417608", "name": "C1417608#ent", "pos": [10, 11]}}
{"token": ["Components", "of", "this", "C0897757#ent", "<e1>", "the", "membrane-bound", "cytochrome", "b558", "and", "the", "cytosolic", "factors", "C1417608#ent", "<e2>", "and", "p67-phox", "."], "h": {"id": "C0897757", "name": "C0897757#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417608", "name": "C1417608#ent", "pos": [13, 14]}}
{"token": ["The", "activity", "of", "gp91phox", ",", "the", "catalytic", "subunit", "the", "C0897757#ent", "<e1>", "is", "stimulated", "by", "the", "regulatory", "subunits", "C1417608#ent", "<e2>", ",", "p67phox", "and", "the", "small", "GTPase", "Rac"], "h": {"id": "C0897757", "name": "C0897757#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417608", "name": "C1417608#ent", "pos": [17, 18]}}
{"token": ["Endothelial", "cells", "expressing", "C1704467#ent", "<e1>", "also", "inhibited", "gamma-radiation-induced", "activation", "of", "C0257535#ent", "<e2>", "p53", "accumulation", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [10, 11]}}
{"token": ["HL60", "cells", "resistant", "to", "C0085752#ent", "<e1>", "contain", "a", "32P-labeled", ",", "Mr", "150,000", "surface", "membrane", "protein", "C1439337#ent", "<e2>", ")", "which", "is", "not", "detected", "in", "cells", "sensitive", "to", "drug", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1439337", "name": "C1439337#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "the", "stimulation", "with", "the", "millimolar", "concentrations", "of", "H(2)O(2", ")", "rapidly", "led", "to", "necrosis", "in", "which", "tyrosine", "phosphorylation", "C0059239#ent", "<e1>", "was", "involved", "at", "the", "downstream", "of", "Lyn", "and", "C0134982#ent", "<e2>", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0134982", "name": "C0134982#ent", "pos": [30, 31]}}
{"token": ["beta1", "integrin", "ligation", "induced", "activation", "of", "Akt", ",", "and", "tyrosine", "phosphorylation", "RAFTK", "and", "C0059239#ent", "<e1>", ",", "but", "not", "C0134982#ent", "<e2>", "in", "REH", "cells", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0134982", "name": "C0134982#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "nuclear", "gene", "C0040083#ent", "<e1>", "TP", ")", "cause", "mitochondrial", "neurogastrointestinal", "encephalomyopathy", "C1705440#ent", "<e2>", ")", ",", "an", "autosomal", "recessive", "disease", "mitochondrial", "dysfunction", "mitochondrial", "DNA", "abnormalities"], "h": {"id": "C0040083", "name": "C0040083#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705440", "name": "C1705440#ent", "pos": [13, 14]}}
{"token": ["Recent", "reports", "of", "C0040083#ent", "<e1>", "mutations", "in", "C1705440#ent", "<e2>", "and", "adenine", "nucleotide", "translocator", "mutations", "adPEO", "have", "given", "new", "insights", "into", "the", "mechanisms", "of", "mtDNA", "maintenance", "in", "mammals", "."], "h": {"id": "C0040083", "name": "C0040083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705440", "name": "C1705440#ent", "pos": [7, 8]}}
{"token": ["They", "are", "sorbitol", "dehydrogenase", "deficiency", "C0751161#ent", "<e1>", "marginal", "maternal", "transferase", "and", "galactokinase", "deficiency", "galactitol", "and", "C0037688#ent", "<e2>", "accumulation", "of", "unknown", "origin", ",", "heterozygosity", "for", "galactosaemia", "and", "galactokinase", "deficiency", "well", "as", "the", "carrier", "state", "Lowe's", "syndrome"], "h": {"id": "C0751161", "name": "C0751161#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [15, 16]}}
{"token": ["Since", "C1421531#ent", "<e1>", "appears", "to", "contribute", "to", "a", "variety", "of", "biological", "processes", "diseases", ",", "C0242706#ent", "<e2>", "O2", "metabolite-mediated", "decreases", "in", "C1421531#ent", "<e1>", "activity", "may", "be", "an", "important", "cellular", "control", "."], "h": {"id": "C0242706", "name": "C0242706#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [1, 2]}}
{"token": ["Reported", "in", "this", "paper", "is", "experience", "obtained", "from", "antenatal", "C1421210#ent", "<e1>", "prophylaxis", ",", "using", "4", "mg", "of", "C0011777#ent", "<e2>", ",", "on", "three", "consecutive", "days", "."], "h": {"id": "C1421210", "name": "C1421210#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [17, 18]}}
{"token": ["C1705433#ent", "<e1>", "classifiers", "often", "comprise", "five", "or", "less", "C1417679#ent", "<e2>", "and", "successfully", "predict", "cancer", "types", "subtypes", "."], "h": {"id": "C1705433", "name": "C1705433#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "applied", "C1705433#ent", "<e1>", "to", "cancer", "expression", "profiling", "data", "to", "select", "feature", "C1417679#ent", "<e2>", "and", "build", "molecular", "classifiers", "mathematical", "integration", "these", "C1417679#ent", "<e2>", "."], "h": {"id": "C1705433", "name": "C1705433#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["A", "case", "of", "chloral", "hydrate", "overdose", "associated", "with", "ventricular", "arrhythmias", "were", "refractory", "to", "treatment", "with", "C0023660#ent", "<e1>", ",", "but", "responsive", "to", "treatment", "with", "C0242889#ent", "<e2>", "reported", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [23, 24]}}
{"token": ["The", "C3889652#ent", "<e1>", "promoter", "was", "used", "to", "drive", "XYL1", "and", "the", "C0342194#ent", "<e2>", "promoter", "to", "drive", "XYL2", "in", "each", "of", "the", "constructs", "."], "h": {"id": "C3889652", "name": "C3889652#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0342194", "name": "C0342194#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "examine", "the", "action", "of", "orally", "administrated", "C0033448#ent", "<e1>", "an", "anticholinergic", "agent", "on", "C0014863#ent", "<e2>"], "h": {"id": "C0033448", "name": "C0033448#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014863", "name": "C0014863#ent", "pos": [19, 20]}}
{"token": ["C0068994#ent", "<e1>", "is", "not", "mutagenic", "to", "C0036117#ent", "<e2>", "but", "becomes", "so", "to", "S.", "typhimurium", "TA98", "and", "YG1024", "with", "S9", "mix", "the", "presence", "of", "the", "non-mutagenic", "aromatic", "amine", ",", "aniline", "."], "h": {"id": "C0068994", "name": "C0068994#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [6, 7]}}
{"token": ["Until", "now", ",", "little", "has", "been", "known", "about", "the", "roles", "of", "C1412458#ent", "<e1>", "in", "the", "localization", "or", "trafficking", "of", "C0287990#ent", "<e2>", "."], "h": {"id": "C1412458", "name": "C1412458#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0287990", "name": "C0287990#ent", "pos": [19, 20]}}
{"token": ["In", "vitro", "histamine", "and", "2,2-pyridylethylamine", "(", "C0340861#ent", "<e1>", ",", "H1", "agonist", "caused", "contraction", "of", "resting", "arteries", "impromidine", "(", "C0019593#ent", "<e2>", "was", "without", "effect", "."], "h": {"id": "C0340861", "name": "C0340861#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [18, 19]}}
{"token": ["Secondly", ",", "it", "shortens", "the", "duration", "of", "C1705341#ent", "<e1>", "activation", "and", "C1415320#ent", "<e2>", "inhibition", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415320", "name": "C1415320#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "C1705341#ent", "<e1>", "alone", "mediates", "the", "IGF1-induced", "inhibition", "of", "C1415320#ent", "<e2>", ",", "while", "the", "MAPK", "cascade", "the", "inhibition", "of", "C1415320#ent", "<e2>", "by", "PMA", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415320", "name": "C1415320#ent", "pos": [11, 12]}}
{"token": ["The", "C0003292#ent", "<e1>", "properties", "of", "acetorphan", ",", "an", "inhibitor", "of", "C0025250#ent", "<e2>", "(", "EC", "3.4.24.11", "that", "prevents", "endogenous", "enkephalin", "degradation", "and", "loperamide", ",", "a", "mu", "opiate", "receptor", "agonist", "were", "compared", "."], "h": {"id": "C0003292", "name": "C0003292#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [10, 11]}}
{"token": ["In", "the", "normal", "thymus", "anlages", "on", "embryonic", "day", ",", "C2983552#ent", "<e1>", "is", "strongly", "expressed", "throughout", "the", "epithelial", "region", "but", "C3815532#ent", "<e2>", "is", "expressed", "only", "in", "scattered", "cells", "."], "h": {"id": "C2983552", "name": "C2983552#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3815532", "name": "C3815532#ent", "pos": [19, 20]}}
{"token": ["C0005283#ent", "<e1>", "major", "patients", "have", "C0581384#ent", "<e2>", "since", "3", "-", "4", "per", "cent", "of", "Singaporeans", "carry", "the", "beta-gene", ",", "prenatal", "diagnosis", "essential", "."], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0581384", "name": "C0581384#ent", "pos": [5, 6]}}
{"token": ["The", "C0005283#ent", "<e1>", "pregnant", "mother", "faces", "deleterious", "consequences", "resulting", "from", "C0581384#ent", "<e2>", "in", "nonsplenectomized", "patients", "there", "remains", "the", "risk", "of", "the", "onset", "of", "a", "hypersplenic", "crisis", "."], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0581384", "name": "C0581384#ent", "pos": [10, 11]}}
{"token": ["A", "pregnant", "patient", "with", "C0005283#ent", "<e1>", "usually", "is", "found", "to", "have", "C0581384#ent", "<e2>", "concurrent", "with", "tissue", "and", "circulatory", "iron", "overload"], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0581384", "name": "C0581384#ent", "pos": [11, 12]}}
{"token": ["We", "now", "report", "that", "the", "activated", "PI", "3-K", "that", "is", "associated", "with", "C1332794#ent", "<e1>", "can", "be", "inhibited", "by", "a", "C0034861#ent", "<e2>", "the", "G", "beta", "gamma-binding", "pleckstrin", "homology", "domain", "beta-adrenergic", "receptor", "kinase", "1", "beta", "ARK-PH", ")", "."], "h": {"id": "C1332794", "name": "C1332794#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [19, 20]}}
{"token": ["The", "sensitive", "strain", ",", "UTEX72", ",", "had", "higher", "levels", "of", "glutathione", "peroxidase", "C0038838#ent", "<e1>", "and", "glucose-6-phosphate", "dehydrogenase", "did", "C1705085#ent", "<e2>"], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705085", "name": "C1705085#ent", "pos": [18, 19]}}
{"token": ["Neither", "an", "antagonist", "of", "leukotriene", "D4", "FPL-55712", ",", "nor", "an", "C0019592#ent", "<e1>", ",", "mepyramine", ",", "had", "any", "effect", "on", "C0235480#ent", "<e2>", "contractions", "."], "h": {"id": "C0019592", "name": "C0019592#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [19, 20]}}
{"token": ["Thus", "PAF-induced", "ocular", "pruritus", "was", "unaffected", "by", "the", "C0019592#ent", "<e1>", "was", "substantially", "attenuated", "by", "the", "C0235480#ent", "<e2>", "antagonists", "WEB", "2086", "and", "CV-6209", "and", "was", "virtually", "abolished", "by", "E-6123", "."], "h": {"id": "C0019592", "name": "C0019592#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [15, 16]}}
{"token": ["By", "radioimmunoassay", ",", "we", "have", "carried", "out", "comparative", "measurements", "of", "the", "serum", "C1366564#ent", "<e1>", "level", "in", "patients", "suffering", "from", "C0014356#ent", "<e2>", "leukemia", "."], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014356", "name": "C0014356#ent", "pos": [19, 20]}}
{"token": ["We", "report", "the", "case", "of", "female", "patient", "with", "systemic", "lupus", "erythematosus", ",", "after", "treatment", "with", "terbinafine", ",", "presented", "a", "C0038325#ent", "<e1>", "together", "with", "renal", "exacerbation", "her", "C0009782#ent", "<e2>"], "h": {"id": "C0038325", "name": "C0038325#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [26, 27]}}
{"token": ["The", "etiologic", "factors", "in", "relation", "with", ":", "C0085411#ent", "<e1>", ",", "portal", "hypertension", "pregnancy", "and", "C0003850#ent", "<e2>", "."], "h": {"id": "C0085411", "name": "C0085411#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [14, 15]}}
{"token": ["Recent", "results", "in", "our", "laboratory", "have", "demonstrated", "that", "C3540778#ent", "<e1>", "affect", "both", "alpha", "1-adrenoceptor", "number", "coupling", "to", "C0086376#ent", "<e2>"], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}}
{"token": ["There", "are", "some", "disorders", ",", "however", ",", "such", "as", "periodic", "C0030196#ent", "<e1>", "movements", "in", "sleep", ",", "restless", "legs", "syndrome", "paroxysmal", "nocturnal", "dystonia", "bruxism", ",", "and", "C0037672#ent", "<e2>", ",", "which", "occur", "primarily", "during", "sleep", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037672", "name": "C0037672#ent", "pos": [25, 26]}}
{"token": ["The", "SDHD", "region", "contains", "another", "gene", ",", "DPP2/TIMM8B", ",", "the", "homolog", "of", "which", "causes", "C0393593#ent", "<e1>", "and", "deafness", "seen", "in", "C0796074#ent", "<e2>"], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [20, 21]}}
{"token": ["The", "levels", "of", "arachidonic", "acid", "AA", ")", "and", "docosahexaenoic", "acid", "C3539567#ent", "<e1>", ")", "were", "higher", "in", "the", "adult", "guinea", "pig", "C1450468#ent", "<e2>", "PE", ")", "fraction", "(", "9", "."], "h": {"id": "C3539567", "name": "C3539567#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1450468", "name": "C1450468#ent", "pos": [20, 21]}}
{"token": ["Lysolecithin", "binding", "to", "the", "membrane", "was", "greatly", "inhibited", "by", "1", "M", "NaCl", "and", "high", "salt", "concentration", "also", "inactivated", "C0702242#ent", "<e1>", "in", "the", "sediment", ",", "suggesting", "an", "electrostatic", "interaction", "between", "C3160060#ent", "<e2>", "and", "membrane", "enzyme"], "h": {"id": "C0702242", "name": "C0702242#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3160060", "name": "C3160060#ent", "pos": [29, 30]}}
{"token": ["C0040805#ent", "<e1>", "clinical", "efficacy", "similar", "to", "that", "of", "amitriptyline", ",", "with", "both", "C0013227#ent", "<e2>", "significantly", "more", "clinical", "improvement", "placebo", "."], "h": {"id": "C0040805", "name": "C0040805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["The", "combination", "of", "C0040805#ent", "<e1>", "and", "mianserin", "has", "no", "additive", "value", "each", "C0013227#ent", "<e2>", "alone", "in", "the", "control", "of", "withdrawal", "symptoms", "opiate-dependent", "mice", "undergoing", "detoxification", "."], "h": {"id": "C0040805", "name": "C0040805#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["A", "minority", "of", "the", "reported", "cases", "of", "C2931817#ent", "<e1>", "clinically", "resemble", "Albright", "hereditary", "osteodystrophy", "C0033835#ent", "<e2>", "and", "have", "only", "mild-to-moderate", "mental", "retardation"], "h": {"id": "C2931817", "name": "C2931817#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033835", "name": "C0033835#ent", "pos": [14, 15]}}
{"token": ["C0010976#ent", "<e1>", "administration", "decreased", "inositol", "polyphosphate", "concentrations", "in", "C0024591#ent", "<e2>", "swine", "."], "h": {"id": "C0010976", "name": "C0010976#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024591", "name": "C0024591#ent", "pos": [8, 9]}}
{"token": ["Incubation", "of", "C2984559#ent", "<e1>", "with", "the", "NO", "donors", ",", "C0037533#ent", "<e2>", "0.1", "and", "1", "mM", ")", "or", "3-morpholino-sydnonimine", "hydrochloride", "(", "SIN-1", ",", "30", "microM", ")", ",", "caused", "a", "dose-dependent", "decrease", "in", "H(+)-ATPase", "activity"], "h": {"id": "C2984559", "name": "C2984559#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [9, 10]}}
{"token": ["We", "speculate", "that", "not", "only", "single", "C0029882#ent", "<e1>", "also", "general", "infections", "repetitive", "middle", "ear", "infections", "contribute", "to", "prolonged", "C2827407#ent", "<e2>"], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C2827407", "name": "C2827407#ent", "pos": [18, 19]}}
{"token": ["Cholesterol-lowering", "statins", "C0003850#ent", "<e1>", "and", "plasma", "C1825621#ent", "<e2>", "levels", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1825621", "name": "C1825621#ent", "pos": [6, 7]}}
{"token": ["C3273406#ent", "<e1>", "apoptosis", "was", "augmented", "in", "the", "presence", "of", "C0072497#ent", "<e2>", "an", "inhibitor", "of", "HO", "activity", ",", "while", "HO-1", "gene", "transfer", "myocytes", "attenuated", "Ang", "II-mediated", "apoptosis", "but", "not", "hypertrophy", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072497", "name": "C0072497#ent", "pos": [9, 10]}}
{"token": ["We", "present", "a", "case", "of", "a", "patient", "who", "preferentially", "consumed", "isopropyl", "C0001962#ent", "<e1>", "for", "at", "least", "17", "years", "and", "developed", "sequelae", "of", "C0007192#ent", "<e2>", "recurrent", "rhabdomyolysis", ",", "cerebellar", "dysfunction", "and", "dementia", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007192", "name": "C0007192#ent", "pos": [22, 23]}}
{"token": ["Acute", "renal", "failure", "disseminated", "intravascular", "coagulation", "C0243025#ent", "<e1>", ",", "hypoglycaemia", ",", "coma", "or", "C0014544#ent", "<e2>", "manifestations", "of", "severe", "Plasmodium", "falciparum", "malaria", "."], "h": {"id": "C0243025", "name": "C0243025#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}}
{"token": ["C0028066#ent", "<e1>", "can", "enhance", "the", "cytotoxicity", "of", "C0003392#ent", "<e2>"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [7, 8]}}
{"token": ["The", "complaints", "included", "C0030193#ent", "<e1>", "in", "the", "head", "and", "neck", ",", "shoulder-arm", "syndrome", "back", "and", "C0004604#ent", "<e2>", "sciatica", "and", "sensitivity", "disorders"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [15, 16]}}
{"token": ["A", "28-year-old", "man", "was", "referred", "to", "our", "hospital", "with", "a", "complaint", "of", "C0030193#ent", "<e1>", "induration", "of", "right", "epididymis", "with", "C0004604#ent", "<e2>", "persistent", "low-grade", "fever", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [19, 20]}}
{"token": ["Pea", "(", "Pisum", "sativum", "L.", ")", "seedling", "C0051604#ent", "<e1>", "C3272401#ent", "<e2>", "is", "the", "first", "C0051604#ent", "<e1>", "be", "crystallized", "that", "diffracts", "to", "atomic", "resolution", "2.5", "A", ")", "."], "h": {"id": "C3272401", "name": "C3272401#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0051604", "name": "C0051604#ent", "pos": [7, 8]}}
{"token": ["C2733158#ent", "<e1>", "be", "involved", "in", "the", "development", "of", "C0018801#ent", "<e2>", "diabetes", "mellitus"], "h": {"id": "C2733158", "name": "C2733158#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [8, 9]}}
{"token": ["A", "number", "of", "key", "players", "have", "been", "implicated", "including", "p53", ",", "pRb", ",", "cyclin", "D2", "p", "INK", "proteins", "C1704888#ent", "<e1>", "and", "the", "C1332391#ent", "<e2>"], "h": {"id": "C1704888", "name": "C1704888#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332391", "name": "C1332391#ent", "pos": [22, 23]}}
{"token": ["C0053828#ent", "<e1>", "inhibited", "the", "elevation", "in", "C0075029#ent", "<e2>", "and", "the", "fall", "in", "platelet", "count", "well", "as", "limiting", "the", "extent", "of", "myocardial", "damage"], "h": {"id": "C0053828", "name": "C0053828#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0075029", "name": "C0075029#ent", "pos": [6, 7]}}
{"token": ["C1514550#ent", "<e1>", "induction", "of", "PPARgamma", "coactivator-1alpha", "PGC-1alpha", ")", "and", "C1421313#ent", "<e2>", "UCP1", ")", "expression", "is", "an", "essential", "step", "in", "the", "commitment", "of", "preadipocytes", "to", "the", "brown", "adipose", "tissue", "BAT", ")", "lineage", "."], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421313", "name": "C1421313#ent", "pos": [9, 10]}}
{"token": ["C0022957#ent", "<e1>", "is", "a", "C1254351#ent", "<e2>", "mainly", "used", "as", "a", "laxative", "and", "for", "the", "treatment", "of", "porto-systemic", "encephalopathy"], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}}
{"token": ["In", "this", "entity", "there", "is", "a", "cytogenic", "deletion", "of", "the", "proximal", "long", "arm", "of", "chromosome", "15q11-q13", "where", "the", "C0079429#ent", "<e1>", "encoding", "the", "GABAA", "receptor", "beta3", "subunit", "(", "C1414916#ent", "<e2>", ")", "is", "located", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414916", "name": "C1414916#ent", "pos": [27, 28]}}
{"token": ["Another", "group", "of", "17", "patients", "who", "responded", "to", "prior", "C0039286#ent", "<e1>", "administration", ",", "upon", "failure", ",", "were", "treated", "with", "C0146868#ent", "<e2>", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0146868", "name": "C0146868#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", "to", "PLD1", ",", "the", "activity", "of", "PLD2", "is", "insensitive", "to", "C0136804#ent", "<e1>", "and", "the", "C0027203#ent", "<e2>", "is", "incapable", "of", "catalyzing", "the", "transphosphatidylation", "reaction", "with", "short", "chain", "alcohols", "acceptors", "."], "h": {"id": "C0136804", "name": "C0136804#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}}
{"token": ["Activation", "of", "MAPKs", "was", "probed", "by", "Western", "blot", "analysis", "the", "C0010536#ent", "<e1>", "ERK", "1/2", ",", "JNK", "1/2", ",", "and", "C1705633#ent", "<e2>", "in", "kappa(1)-LC-exposed", "human", "PTCs", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [19, 20]}}
{"token": ["These", "data", "suggest", "that", "SB-203580", "likely", "attenuates", "IPC", "via", "the", "inhibition", "of", "C0010536#ent", "<e1>", "other", "than", "C1705633#ent", "<e2>", ",", "which", "may", "include", "JNK", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [16, 17]}}
{"token": ["Combining", "C0083381#ent", "<e1>", "with", "DXR", "significantly", "up-regulated", "C0812198#ent", "<e2>", "expression", ",", "whereas", "it", "down-regulated", "Bcl-2", "expression", "in", "combination", "with", "CDDP", "."], "h": {"id": "C0083381", "name": "C0083381#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [7, 8]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "clarify", "the", "difference", "in", "quality", "of", "C0017168#ent", "<e1>", "treatment", "with", "PPIs", "and", "H(2)-RA", "in", "step-down", "protocol", "using", "C2348248#ent", "<e2>", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C2348248", "name": "C2348248#ent", "pos": [24, 25]}}
{"token": ["We", "investigated", "the", "heartburn", "symptoms", "of", "patients", "with", "C0017168#ent", "<e1>", "sequential", "treatment", "40", "mg", "of", "famotidine", "or", "15", "mg", "of", "C2348248#ent", "<e2>", "to", "clarify", "whether", "H.", "pylori", "infection", "symptomatic", "response", "to", "anti-secretory", "therapy", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C2348248", "name": "C2348248#ent", "pos": [20, 21]}}
{"token": ["The", "dosage", "range", "used", "for", "the", "management", "of", "C0017168#ent", "<e1>", "and", "related", "disorders", "with", "C2348248#ent", "<e2>", "was", "0.73", "-", "1.66", "mg/kg/day", "(", "maximum", "30", "mg/day", ")", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C2348248", "name": "C2348248#ent", "pos": [14, 15]}}
{"token": ["Exceptions", "include", "T-cell-rich", "B-cell", "lymphoma", "C1334119#ent", "<e1>", ")", ",", "angioimmunoblastic", "lymphadenopathy-like", "T-cell", "lymphoma", "plasmacytosis", "and", "C0154254#ent", "<e2>", "(", "IL-6", ")", ",", "anaplastic", "large-cell", "lymphoma", "IL-9", ")", ",", "polymorphic", "immunocytoma", "IL-6", ")", ",", "and", "immunoblastic", "lymphoma", "IBL", ")", "(", "IL-6", ")", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0154254", "name": "C0154254#ent", "pos": [15, 16]}}
{"token": ["Our", "analysis", "therefore", "has", "revealed", "distinct", "mutational", "spectra", "clarified", "the", "roles", "of", "C0879392#ent", "<e1>", "and", "Msh6", "in", "C1333237#ent", "<e2>", "intestinal", "tumorigenesis", "."], "h": {"id": "C0879392", "name": "C0879392#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [17, 18]}}
{"token": ["The", "gene", "(", "CYP11B1", ")", "coding", "for", "this", "enzyme", "is", "highly", "C1334043#ent", "<e1>", "with", "and", "lies", "a", "relatively", "short", "distance", "from", "the", "gene", "coding", "C1527416#ent", "<e2>", "CYP11B2", ")", "on", "chromosome", "8"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1527416", "name": "C1527416#ent", "pos": [24, 25]}}
{"token": ["Inhibition", "of", "either", "Erk", "or", "C0044602#ent", "<e1>", "blocked", "the", "capacity", "of", "both", "activated", "C1367476#ent", "<e2>", "and", "activated", "H-Ras", "to", "support", "proliferation", "and", "viability", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367476", "name": "C1367476#ent", "pos": [13, 14]}}
{"token": ["Instead", ",", "a", "dominant", "negative", "mutant", "of", "C0044602#ent", "<e1>", "PI3-K", ")", "drastically", "inhibited", "the", "oncogenic", "potential", "of", "C1367476#ent", "<e2>", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367476", "name": "C1367476#ent", "pos": [17, 18]}}
{"token": ["Increase", "in", "the", "content", "of", "C0077025#ent", "<e1>", "and", "trioctanoin", "in", "the", "mixture", "with", "C0040853#ent", "<e2>", "had", "highly", "cooperative", "effects", "the", "formation", "of", "the", "interfacial", "lipase", "procolipase", "complex"], "h": {"id": "C0077025", "name": "C0077025#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040853", "name": "C0040853#ent", "pos": [13, 14]}}
{"token": ["Enzymes", "in", "the", "effluent", "fractions", "were", "assayed", "titrimetrically", "for", "their", "hydrolytic", "activities", "towards", "C0077025#ent", "<e1>", ",", "triolein", "and", "milk-fat", "emulsions", ",", "and", "C0040853#ent", "<e2>", "solution", "."], "h": {"id": "C0077025", "name": "C0077025#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040853", "name": "C0040853#ent", "pos": [22, 23]}}
{"token": ["The", "terpolymeric", "carrier", "was", "plasticized", "by", "C0040853#ent", "<e1>", ",", "C0077025#ent", "<e2>", ",", "or", "a", "mixture", "of", "C0040853#ent", "<e1>", "with", "tricaprylin", "."], "h": {"id": "C0077025", "name": "C0077025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040853", "name": "C0040853#ent", "pos": [6, 7]}}
{"token": ["Several", "TF/FVIIa", "inhibitors", "are", "in", "development", ",", "including", "the", "C1449702#ent", "<e1>", "such", "as", "C2347906#ent", "<e2>", ",", "Corsevin", "M", ",", "FFR-FVIIa", ",", "and", "Tifacogin", ")", "."], "h": {"id": "C1449702", "name": "C1449702#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2347906", "name": "C2347906#ent", "pos": [13, 14]}}
{"token": ["Pronuciferine", "and", "armepavine", "were", "isolated", "as", "the", "major", "alkaloids", "from", "a", "sample", "of", "P.", "tauricola", "with", "C0028426#ent", "<e1>", ",", "roemerine", ",", "nuciferine", ",", "nantenine", "and", "C0072495#ent", "<e2>", "as", "minor", "alkaloids", "."], "h": {"id": "C0028426", "name": "C0028426#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0072495", "name": "C0072495#ent", "pos": [25, 26]}}
{"token": ["Pancreatic", "enzyme", "extracts", "have", "been", "used", "for", "several", "decades", "to", "decrease", "maldigestion", "of", "macro-", "and", "micronutrients", "due", "to", "pancreatic", "insufficiency", "to", "alleviate", "various", "C0740651#ent", "<e1>", "including", "the", "pain", "of", "C0341470#ent", "<e2>", "distal", "intestinal", "obstruction"], "h": {"id": "C0740651", "name": "C0740651#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0341470", "name": "C0341470#ent", "pos": [29, 30]}}
{"token": ["Sheep", "infected", "with", "C0032306#ent", "<e1>", "tested", "for", "immune", "reactivity", "recombinant", "C3538704#ent", "<e2>", "and", "tuberculin", "PPD", "mycobacteria", "."], "h": {"id": "C0032306", "name": "C0032306#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "C0025250#ent", "<e1>", "levels", "are", "highly", "variable", "in", "C1704942#ent", "<e2>", "of", "normal", "volunteers", "and", "are", "low", "or", "undetectable", "in", "most", "C1704942#ent", "<e2>", "specimens", "from", "patients", "with", "lung", "cancer"], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [10, 11]}}
{"token": ["In", "vivo", "toxicity", "studies", "no", "effect", "of", "EGTA", ",", "C0025250#ent", "<e1>", ",", "or", "C12", "on", "weight", "gain", "lung", "edema", "or", "bronchoalveolar", "lavage", "fluid", "C1704942#ent", "<e2>", ")", "albumin", "."], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [23, 24]}}
{"token": ["C0025250#ent", "<e1>", "had", "no", "effect", "on", "C1704942#ent", "<e2>", "cell", "counts", "LDH", ",", "but", "increased", "murine", "tumor", "necrosis", "factor", "alpha"], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [6, 7]}}
{"token": ["This", "patient", "represents", "the", "unusual", "occurrence", "of", "C0398623#ent", "<e1>", "in", "a", "patient", "with", "C1414542#ent", "<e2>"], "h": {"id": "C0398623", "name": "C0398623#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414542", "name": "C1414542#ent", "pos": [13, 14]}}
{"token": ["The", "best", "bis(alpha-ketocarboxylic", "acid", ")", "inhibitor", "34", "had", "an", "IC(50", ")", "value", "of", "550nM", "against", "the", "C0043407#ent", "<e1>", "PTP", "and", "an", "IC(50", ")", "value", "of", "710nM", "against", "C1419100#ent", "<e2>", "."], "h": {"id": "C0043407", "name": "C0043407#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419100", "name": "C1419100#ent", "pos": [27, 28]}}
{"token": ["The", "C1257945#ent", "<e1>", "one", "of", "the", "four", "subunits", "of", "C1256818#ent", "<e2>", "SCFs", "(", "SKP1-cullin-F-box", ")", ",", "which", "governs", "phosphorylation-dependent", "ubiquitination", "and", "subsequent", "proteolysis", "."], "h": {"id": "C1257945", "name": "C1257945#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1256818", "name": "C1256818#ent", "pos": [9, 10]}}
{"token": ["In", "fact", ",", "C1257945#ent", "<e1>", "one", "of", "the", "four", "subunits", "of", "C1256818#ent", "<e2>", "SCFs", "."], "h": {"id": "C1257945", "name": "C1257945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1256818", "name": "C1256818#ent", "pos": [11, 12]}}
{"token": ["C1414529#ent", "<e1>", "regimen", "(", "5-fluorouracil", ",", "Adriamycin", ",", "and", "C1161438#ent", "<e2>", ")", "was", "given", "to", "6", "patients", "(", "40", "%", ")", "."], "h": {"id": "C1414529", "name": "C1414529#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [9, 10]}}
{"token": ["CYP2E1-dependent", "p-nitrophenol", "hydroxylase", "(", "C1417772#ent", "<e1>", ")", "activity", "was", "also", "increased", "by", "C0053490#ent", "<e2>", "microsomes", "prepared", "from", "kidney", "(", "3.1-fold", ")", ",", "whereas", "alphaNF", "was", "without", "effect", "."], "h": {"id": "C1417772", "name": "C1417772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0053490", "name": "C0053490#ent", "pos": [12, 13]}}
{"token": ["D-Limonene", "inhibited", "p-nitrophenol", "hydroxylase", "C1417772#ent", "<e1>", ")", "activity", "in", "vitro", "liver", "microsomes", "acetone-", ",", "phenobarbital", "(PB)-", "and", "C0053490#ent", "<e2>", "(BNF)-treated", "mouse", ",", "and", "7-ethoxyresorufin", "O-deethylase", "EROD", ")", "activity", "in", "microsomes", "from", "PB-", "and", "BNF-treated", "mouse", "."], "h": {"id": "C1417772", "name": "C1417772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0053490", "name": "C0053490#ent", "pos": [17, 18]}}
{"token": ["A", "case", "of", "a", "3", "years", "old", "female", "child", "suffering", "from", "C0162359#ent", "<e1>", "features", "of", "C0035459#ent", "<e2>", "infancy", "&", "early", "childhood", "reported", "here", "."], "h": {"id": "C0162359", "name": "C0162359#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0035459", "name": "C0035459#ent", "pos": [15, 16]}}
{"token": ["The", "C1414387#ent", "<e1>", "human", "Pim1", "(", "hereafter", "PIM1", ")", "cooperates", "with", "human", "C0079068#ent", "<e2>", "(", "hereafter", "MYC", ")", "in", "cell", "cycle", "progression", "tumorigenesis", "."], "h": {"id": "C1414387", "name": "C1414387#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [12, 13]}}
{"token": ["Four", "further", "inherited", "or", "acquired", "disorders", "the", "C0019120#ent", "<e1>", "known", ":", "prothrombin", "dimorphism", ",", "antithrombin", ",", "protein", "C", "protein", "S", "C2713546#ent", "<e2>", "."], "h": {"id": "C0019120", "name": "C0019120#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [20, 21]}}
{"token": ["Immunohistology", "was", "by", "far", "the", "most", "sensitive", "method", "for", "detection", "of", "diffuse", "plaques", "C0085220#ent", "<e1>", "followed", "by", "the", "Campbell-Switzer", ",", "Reusche", ",", "C0011860#ent", "<e2>", "."], "h": {"id": "C0085220", "name": "C0085220#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [22, 23]}}
{"token": ["Active", "demyelination", "be", "demonstrated", "with", "C3813556#ent", "<e1>", "contrast", "enhancement", "(", "C2750737#ent", "<e2>", ")", "as", "regions", "of", "increased", "x-ray", "density"], "h": {"id": "C3813556", "name": "C3813556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2750737", "name": "C2750737#ent", "pos": [10, 11]}}
{"token": ["C3274822#ent", "<e1>", "decreased", "significantly", "on", "both", "the", "C0700460#ent", "<e2>", "and", "the", "combination", "therapy", "but", "increased", "during", "the", "following", "placebo", "and", "hydralazine", "periods", "to", "a", "level", "slightly", "higher", "than", "the", "initial", "level", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0700460", "name": "C0700460#ent", "pos": [7, 8]}}
{"token": ["The", "increase", "in", "C3274822#ent", "<e1>", "following", "diazoxide", "was", "partially", "blocked", "by", "C0700460#ent", "<e2>", ",", "adrenalectomy", "and", "demedullation", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0700460", "name": "C0700460#ent", "pos": [11, 12]}}
{"token": ["Exact", "tests", "population", "differentiation", "indicate", "significant", "variations", "in", "C1706112#ent", "<e1>", "distributions", ",", "particularly", "at", "loci", "C2700283#ent", "<e2>", ",", "DXS981", "and", "DXS6789", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2700283", "name": "C2700283#ent", "pos": [15, 16]}}
{"token": ["C1412446#ent", "<e1>", "while", "the", "C0017978#ent", "<e2>", ",", "sphingomyelin", "and", "cerebroside", "and", "the", "sterol", "cholesterol", "did", "not", "form", "TBA", "reactive", "materials"], "h": {"id": "C1412446", "name": "C1412446#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017978", "name": "C0017978#ent", "pos": [4, 5]}}
{"token": ["Our", "patient's", "C0563238#ent", "<e1>", "represents", "a", "previously", "undescribed", "manifestation", "of", "C0038395#ent", "<e2>"], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038395", "name": "C0038395#ent", "pos": [10, 11]}}
{"token": ["Growth", "hormone-excess", "C3714796#ent", "<e1>", "been", "reported", "to", "be", "associated", "with", "increased", "risk", "for", "C0004153#ent", "<e2>", ";", "an", "association", "with", "serum", "lipoprotein", "changes", "is", "likely", "but", "evidence", "for", "a", "causal", "link", "is", "yet", "lacking", "."], "h": {"id": "C3714796", "name": "C3714796#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [13, 14]}}
{"token": ["Total", "C0252270#ent", "<e1>", "activity", "was", "unaltered", "when", "assayed", "with", "32P-labeled", "IR", "and", "C1704984#ent", "<e2>", "."], "h": {"id": "C0252270", "name": "C0252270#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704984", "name": "C1704984#ent", "pos": [12, 13]}}
{"token": ["In", "the", "absence", "of", "evidence", "of", "arteritis", "or", "Wegener's", "granulomatosis", "the", "syndrome", "of", "lung", "hemorrhage", "C0027697#ent", "<e1>", "has", "been", "commonly", "associated", "with", "C1332309#ent", "<e2>", "GBM", ")", "antibodies", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332309", "name": "C1332309#ent", "pos": [22, 23]}}
{"token": ["Salt-dependent", "structural", "changes", "of", "rat", "C0008546#ent", "<e1>", "isolated", "by", "an", "extraction", "procedure", "involving", "shear", "and", "exogenous", "C0035542#ent", "<e2>", "were", "investigated", "by", "sedimentation", "and", "light", "scattering", "methods"], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "active", "maternal", "alleles", "C0008546#ent", "<e1>", "of", "MatDi7", "embryos", "are", "more", "sensitive", "and", "accessible", "to", "C0035542#ent", "<e2>", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [16, 17]}}
{"token": ["In", "GH3", "pituitary", "cells", "the", "Kv1.4", "and", "Kv1.5", "subunit", "genes", "are", "C0907533#ent", "<e1>", "expressed", ",", "and", "C0011777#ent", "<e2>", "selectively", "up-regulates", "expression", "of", "the", "latter", "gene", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [16, 17]}}
{"token": ["Amy-1", "is", "C0907533#ent", "<e1>", "active", "in", "these", "cells", "and", "is", "inducible", "by", "C0011777#ent", "<e2>", "at", "the", "level", "of", "mRNA", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}}
{"token": ["One", "key", "element", "in", "cellular", "response", "the", "C1420639#ent", "<e1>", "which", "can", "regulate", "nearly", "100", "C1417679#ent", "<e2>", "that", "have", "already", "been", "identified", "."], "h": {"id": "C1420639", "name": "C1420639#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}}
{"token": ["An", "C1420639#ent", "<e1>", "was", "identified", "from", "Arabidopsis", "thaliana", "expression", "patterns", "of", "the", "C1417679#ent", "<e2>", "from", "a", "microarray", "analysis", "examined", "."], "h": {"id": "C1420639", "name": "C1420639#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["A", "C0035086#ent", "<e1>", "shape", "is", "suitable", "for", "particle", "light", "valve", "(", "C0812295#ent", "<e2>", ")", "applications", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812295", "name": "C0812295#ent", "pos": [11, 12]}}
{"token": ["Adrenalectomy", ",", "demedullation", "and", "pretreatment", "with", "reserpine", ",", "C0031448#ent", "<e1>", ",", "nicotinamide", "and", "C3536880#ent", "<e2>", "blocked", "the", "hyperglycaemic", "response", "guanethidine", "and", "propranolol", "or", "oxprenolol", "were", "ineffective", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536880", "name": "C3536880#ent", "pos": [13, 14]}}
{"token": ["WNK", "kinases", "comprise", "a", "small", "group", "unique", "C1413288#ent", "<e1>", "have", "been", "C1516876#ent", "<e2>", "linked", "to", "pseudohypoaldosteronism", "type", "II", "an", "autosomal", "dominant", "form", "of", "hypertension", "."], "h": {"id": "C1413288", "name": "C1413288#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [11, 12]}}
{"token": ["C1415825#ent", "<e1>", "is", "somewhat", "less", "effective", "than", "C0041236#ent", "<e2>", "."], "h": {"id": "C1415825", "name": "C1415825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [7, 8]}}
{"token": ["Performance", "of", "daily", "activities", "may", "be", "affected", "by", "the", "unpredictable", "nature", ";", "often", "late-onset", "degenerative", "changes", "cause", "permanent", "disability", "for", "example", ",", "muscle", "atrophy", "C3714552#ent", "<e1>", "periodic", "paralysis", "cerebellar", "atrophy", "progressive", "ataxia", "in", "the", "C1847839#ent", "<e2>"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [24, 25]}, "relation": "manifestation_of", "t": {"id": "C1847839", "name": "C1847839#ent", "pos": [34, 35]}}
{"token": ["When", "the", "growth", "reaction", "above", "the", "C0242301#ent", "<e1>", "point", "of", "an", "C0524926#ent", "<e2>", "the", "surface", "ligand", "dynamics", "was", "violent", ",", "a", "quasi-gas-phase", "state", ",", "indicated", "by", "strong", "temperature-dependent", "and", "fast", "growth", "rates", "the", "nanocrystals", "."], "h": {"id": "C0242301", "name": "C0242301#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524926", "name": "C0524926#ent", "pos": [11, 12]}}
{"token": ["It", "was", "nearly", "possible", "to", "compensate", "the", "negative", "effect", "of", "C0032950#ent", "<e1>", "on", "the", "carbohydrate", "metabolism", "C0360396#ent", "<e2>", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0360396", "name": "C0360396#ent", "pos": [16, 17]}}
{"token": ["Neuraminidase", "produced", "by", "11", "strains", "of", "group", "B", "streptococci", "C4083008#ent", "<e1>", ")", ",", "from", "serotypes", "Ia", "Ib", ",", "Ic", ",", "C3273406#ent", "<e2>", ",", "and", "III", ",", "were", "characterized", "according", "to", "molecular", "weight", "antigenic", "identity", "and", "substrate", "specificity"], "h": {"id": "C4083008", "name": "C4083008#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [20, 21]}}
{"token": ["Sub-optimal", "treatment", "response", "C0008809#ent", "<e1>", "was", "observed", "in", "17", "%", "of", "the", "cases", "of", "C0006818#ent", "<e2>", "6", "%", "due", "to", "other", "causes", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0006818", "name": "C0006818#ent", "pos": [14, 15]}}
{"token": ["Results", "of", "this", "study", "confirm", "the", "existence", "of", "antimicrobial", "resistance", "Campylobacter", "to", "various", "antimicrobial", "agents", "especially", "C0008809#ent", "<e1>", "and", "erythromycin", ",", "commonly", "used", "for", "treatment", "of", "C0006818#ent", "<e2>", "in", "humans", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0006818", "name": "C0006818#ent", "pos": [26, 27]}}
{"token": ["The", "early", "risk", "C0027051#ent", "<e1>", "coronary", "revascularization", "also", "reduced", "by", "C0070166#ent", "<e2>", "in", "patients", "submitted", "to", "PCI", ",", "an", "effect", "already", "demonstrated", "with", "tirofiban", "and", "integrilin", "(", "\"", "small", "molecules", "\"", "effect", ")", "."], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0070166", "name": "C0070166#ent", "pos": [10, 11]}}
{"token": ["Of", "the", "C0026902#ent", "<e1>", "myc", "was", "amplified", "in", "14", "of", "137", "tumors", "and", "C0812289#ent", "<e2>", "in", "four", "of", "108", "tumors", ",", "but", "N-myc", "was", "not", "amplified", "."], "h": {"id": "C0026902", "name": "C0026902#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812289", "name": "C0812289#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "demonstrate", "that", "exocytosis", "of", "C1416612#ent", "<e1>", "the", "plasma", "membrane", "the", "small", "C0018296#ent", "<e2>", "RAB11", ",", "whereas", "endocytosis", "is", "dependent", "on", "RAB5", "."], "h": {"id": "C1416612", "name": "C1416612#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [13, 14]}}
{"token": ["An", "increased", "C0427008#ent", "<e1>", "was", "quantified", "in", "Duane's", "syndrome", "C0339143#ent", "<e2>", "orbital-floor", "fracture", "and", "superior", "oblique", "palsy"], "h": {"id": "C0427008", "name": "C0427008#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [9, 10]}}
{"token": ["Down-regulation", "of", "C1335227#ent", "<e1>", "by", "small", "interfering", "RNA", "the", "mobility-shifted", ",", "hyperphosphorylated", "form", "of", "C1412854#ent", "<e2>", "in", "the", "prometaphase-arrested", "cells", "."], "h": {"id": "C1335227", "name": "C1335227#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412854", "name": "C1412854#ent", "pos": [14, 15]}}
{"token": ["Pentaerythritol", "tetranitrate", "C0030858#ent", "<e1>", ",", "NF", ")", "is", "a", "drug", "used", "to", "prevent", "C0002962#ent", "<e2>"], "h": {"id": "C0030858", "name": "C0030858#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [13, 14]}}
{"token": ["DNA", "microarray", "demonstrate", "that", "C3541976#ent", "<e1>", "is", "one", "of", "the", "most", "highly", "upregulated", "C0017337#ent", "<e2>", "in", "response", "to", "LGG-CM", "treatment", "."], "h": {"id": "C3541976", "name": "C3541976#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["C3541976#ent", "<e1>", "is", "a", "member", "of", "the", "HSP70", "family", "of", "C0017337#ent", "<e2>", "which", "has", "been", "shown", "to", "be", "inducible", "in", "a", "variety", "of", "circumstances", "."], "h": {"id": "C3541976", "name": "C3541976#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["Overall", ",", "these", "data", "highlight", "the", "essential", "role", "played", "by", "C3541976#ent", "<e1>", "expression", "in", "Leishmania", "virulence", "pointing", "to", "this", "C0017337#ent", "<e2>", "as", "a", "promising", "target", "for", "therapeutic", "interventions"], "h": {"id": "C3541976", "name": "C3541976#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["To", "report", "a", "case", "of", "\"", "C0038165#ent", "<e1>", "(", "SMS", ")", "caused", "by", "C0065374#ent", "<e2>", "."], "h": {"id": "C0038165", "name": "C0038165#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [13, 14]}}
{"token": ["In", "the", "absence", "of", "ligands", ",", "PXR", "can", "also", "repress", "gene", "expression", "interacting", "with", "C1336779#ent", "<e1>", "such", "as", "the", "silencing", "mediator", "for", "C0035339#ent", "<e2>", "and", "thyroid", "hormone", "receptor", "SMRT", ")", "."], "h": {"id": "C1336779", "name": "C1336779#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [22, 23]}}
{"token": ["Increasing", "C0012177#ent", "<e1>", "40", "to", "80", "g", "per", "day", "raised", "fasting", "C0026454#ent", "<e2>", "concentration", "by", "30", "to", "70", "per", "cent", "within", "three", "days", "in", "both", "encephalopathic", "and", "non-encephalopathic", "cirrhotic", "patients", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [11, 12]}}
{"token": ["C0043119#ent", "<e1>", "a", "genetic", "progeria", "disorder", "by", "mutation", "of", "the", "Werner", "gene", "C0388246#ent", "<e2>", ")", "."], "h": {"id": "C0043119", "name": "C0043119#ent", "pos": [0, 1]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0388246", "name": "C0388246#ent", "pos": [12, 13]}}
{"token": ["Pre-treatment", "of", "neurons", "with", "C3537460#ent", "<e1>", "inhibitor", "bumetanide", "inhibited", "upregulation", "of", "C1415761#ent", "<e2>", "and", "attenuated", "the", "level", "of", "cleaved", "caspase", "12", "p-eIF2alpha", "."], "h": {"id": "C3537460", "name": "C3537460#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415761", "name": "C1415761#ent", "pos": [11, 12]}}
{"token": ["C0086140#ent", "<e1>", "does", "not", "serve", "only", "as", "plasma", "expander", "but", "also", "corrects", "C0398623#ent", "<e2>", "and", "improves", "the", "rheological", "qualities", "of", "circulating", "blood"], "h": {"id": "C0086140", "name": "C0086140#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [12, 13]}}
{"token": ["C0216278#ent", "<e1>", "tinzaparin", ";", "innohep", ")", "is", "a", "low", "C0019139#ent", "<e2>", "LMWH", ")", "formed", "by", "the", "enzymatic", "degradation", "porcine", "unfractionated", "heparin", "(", "UFH", ")", "."], "h": {"id": "C0216278", "name": "C0216278#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [9, 10]}}
{"token": ["There", "is", "evidence", "that", "patients", "with", "C0264722#ent", "<e1>", "endothelial", "cell-related", "abnormalities", "of", "the", "peripheral", "circulation", "the", "C2827469#ent", "<e2>"], "h": {"id": "C0264722", "name": "C0264722#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2827469", "name": "C2827469#ent", "pos": [16, 17]}}
{"token": ["Recent", "evidences", "indicate", "that", "the", "products", "of", "the", "C1708598#ent", "<e1>", "kisspeptins", ",", "and", "their", "specific", "receptor", "C1708145#ent", "<e2>", ",", "represent", "potent", "stimulators", "of", "the", "sexual", "axis"], "h": {"id": "C1708598", "name": "C1708598#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1708145", "name": "C1708145#ent", "pos": [16, 17]}}
{"token": ["Kisspeptin", ",", "the", "product", "derived", "from", "C1708598#ent", "<e1>", ",", "and", "its", "cognate", "receptor", ",", "C1708145#ent", "<e2>", ",", "both", "exert", "a", "role", "in", "the", "neuroendocrine", "control", "reproduction", "by", "regulating", "gonadotrophin-releasing", "hormone", "GnRH", ")", "secretion", "."], "h": {"id": "C1708598", "name": "C1708598#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1708145", "name": "C1708145#ent", "pos": [14, 15]}}
{"token": ["In", "particular", ",", "a", "nonsense", "mutation", "C1332672#ent", "<e1>", "has", "been", "identified", "in", "a", "rat", "model", "of", "C0011854#ent", "<e2>"], "h": {"id": "C1332672", "name": "C1332672#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "we", "have", "examined", "the", "role", "of", "a", "truncated", "variant", "of", "C1332672#ent", "<e1>", "related", "to", "the", "rat", "model", "of", "C0011854#ent", "<e2>", "the", "mast", "cell", "signaling", "model"], "h": {"id": "C1332672", "name": "C1332672#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [22, 23]}}
{"token": ["C1412626#ent", "<e1>", "(", "Atoh1", ")", "is", "a", "basic", "C3273649#ent", "<e2>", "for", "intestinal", "secretory", "cell", "."], "h": {"id": "C1412626", "name": "C1412626#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273649", "name": "C3273649#ent", "pos": [8, 9]}}
{"token": ["C1412626#ent", "<e1>", "is", "a", "basic", "C3273649#ent", "<e2>", "for", "hair", "cell", "HC", ")", "differentiation", "in", "the", "inner", "ear"], "h": {"id": "C1412626", "name": "C1412626#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273649", "name": "C3273649#ent", "pos": [5, 6]}}
{"token": ["Three", "other", "patients", "without", "C0023890#ent", "<e1>", "(", "controls", ")", "received", "C0700450#ent", "<e2>", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0700450", "name": "C0700450#ent", "pos": [10, 11]}}
{"token": ["Besides", "Brazilian", "C0263314#ent", "<e1>", "C1415790#ent", "<e2>", ")", ",", "we", "have", "described", "another", "focus", "of", "C1415790#ent", "<e2>", "in", "Colombia", "."], "h": {"id": "C0263314", "name": "C0263314#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415790", "name": "C1415790#ent", "pos": [4, 5]}}
{"token": ["The", "cleavage", "of", "the", "C0021699#ent", "<e1>", "APP", ")", "by", "C1569775#ent", "<e2>", "C-terminal", "fragment", "APP", ",", "C99", ",", "anchored", "in", "the", "plasma", "membrane"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [4, 5]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C1569775", "name": "C1569775#ent", "pos": [9, 10]}}
{"token": ["Patients", "with", "C0002736#ent", "<e1>", "ALS", ")", "show", "disorganised", "collagen", "and", "C1414382#ent", "<e2>", "of", "the", "dermis", "."], "h": {"id": "C0002736", "name": "C0002736#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [10, 11]}}
{"token": ["In", "summary", ",", "our", "study", "identifies", "CalDAG-GEFI", "and", "PKC", "as", "independent", "pathways", "leading", "to", "C1426113#ent", "<e1>", "and", "alphaIIbbeta3", "activation", "in", "mouse", "platelets", "activated", "through", "the", "C1709385#ent", "<e2>"], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1709385", "name": "C1709385#ent", "pos": [25, 26]}}
{"token": ["Using", "radiolabelled", "sulphur", "uptake", "measure", "cartilage", "metabolism", "we", "quantitatively", "assessed", "the", "in-vitro", "effect", "of", "C0029408#ent", "<e1>", "and", "non-osteoarthritic", "human", "cartilage", "exposure", "to", "C0008196#ent", "<e2>", "0.05", "%", "for", "1min", "and", "1h", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0008196", "name": "C0008196#ent", "pos": [22, 23]}}
{"token": ["The", "effect", "of", "the", "Ca2", "+", "antagonists", "on", "the", "carbachol-induced", "contractions", "was", "studied", "by", "adding", "increasing", "concentrations", "of", "verapamil", "or", "C0028127#ent", "<e1>", "to", "the", "bath", "solution", "min", "prior", "to", "C0006945#ent", "<e2>", "."], "h": {"id": "C0028127", "name": "C0028127#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [29, 30]}}
{"token": ["Almost", "none", "of", "69", "intramuscular", "arteries", "examined", "were", "strongly", "stained", "with", "C1453024#ent", "<e1>", "SDH", ")", "except", "one", "patient", "who", "had", "2", "C1705597#ent", "<e2>", "(", "strongly", "SDH-reactive", "blood", "vessels", ")", "in", "his", "muscle", "biopsy"], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705597", "name": "C1705597#ent", "pos": [21, 22]}}
{"token": ["After", "measuring", "hemodynamic", "effects", "in", "a", "normal", "heart", "C0018802#ent", "<e1>", "induced", "by", "the", "infusion", "of", "C0033497#ent", "<e2>", "(", "5", "mg/kg", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [15, 16]}}
{"token": ["A", "significant", "reversal", "of", "C0018802#ent", "<e1>", "attained", "in", "anaesthetised", "dogs", "subjected", "to", "C0033497#ent", "<e2>", "induced", "cardiac", "insufficiency"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [12, 13]}}
{"token": ["Genetic", "diseases", "that", "the", "normal", "function", "CNS", "myelin", "depends", "on", "connexin32", "(", "C1415076#ent", "<e1>", ")", "and", "Cx47", ",", "gap", "junction", "GJ", ")", "C0086376#ent", "<e2>", "expressed", "by", "oligodendrocytes", "."], "h": {"id": "C1415076", "name": "C1415076#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "the", "relationship", "between", "hepatocarcinogenesis", "and", "the", "expression", "of", "connexin32", "(", "C1415076#ent", "<e1>", ")", ",", "connexin43", "(", "cx43", ")", "mRNAs", "and", "C0086376#ent", "<e2>", "in", "vitro"], "h": {"id": "C1415076", "name": "C1415076#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [22, 23]}}
{"token": ["We", "have", "isolated", "a", "gene-specific", "activator", "C3469945#ent", "<e1>", ",", "and", "the", "C0065017#ent", "<e2>", "yeast", ",", "OLE1", ",", "as", "multicopy", "suppressors", "of", "an", "mga2Delta", "spt23", "temperature-sensitive", "mutation", "(", "spt23-ts", ")", "."], "h": {"id": "C3469945", "name": "C3469945#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0065017", "name": "C0065017#ent", "pos": [11, 12]}}
{"token": ["These", "in", "vivo", "results", "agree", "with", "our", "previous", "studies", "of", "the", "effects", "of", "C0066447#ent", "<e1>", "on", "the", "formation", "of", "NAPQI", "in", "rat", "C0023899#ent", "<e2>", "microsomes", "."], "h": {"id": "C0066447", "name": "C0066447#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [22, 23]}}
{"token": ["Constitutively", "active", "C1366537#ent", "<e1>", "and", "Rac1", "inhibited", "C1413043#ent", "<e2>", "+", "sensitization", "by", "GTP", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [7, 8]}}
{"token": ["Although", "C0003775#ent", "<e1>", "is", "a", "product", "of", "the", "catalytic", "action", "deficient", "C3888272#ent", "<e2>", "citrullinemia", ",", "its", "concentration", "was", "found", "to", "be", "elevated", "in", "the", "urine", "of", "patients", "with", "type", "II", "citrullinemia"], "h": {"id": "C0003775", "name": "C0003775#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3888272", "name": "C3888272#ent", "pos": [11, 12]}}
{"token": ["C0003775#ent", "<e1>", "catalysis", "indicated", "the", "presence", "of", "C3888272#ent", "<e2>", "argininosuccinase", "activities", "."], "h": {"id": "C0003775", "name": "C0003775#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3888272", "name": "C3888272#ent", "pos": [7, 8]}}
{"token": ["Given", "as", "concurrent", "intravenous", "infusions", "C0062637#ent", "<e1>", ",", "5-Meo-DMT", "and", "4-DAMP", "added", "to", "C0031978#ent", "<e2>", "or", "atropine", "did", "not", "significantly", "increase", "LES", "relaxation", "latency", "above", "that", "caused", "by", "C0031978#ent", "<e2>", "or", "atropine", "alone", "."], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [13, 14]}}
{"token": ["During", "chronic", "experiments", "myoelectric", "and", "mechanical", "recordings", "were", "performed", "in", "fasted", "and", "non-fasted", "animals", "before", "and", "after", "various", "doses", "of", "C0062637#ent", "<e1>", ",", "atropine", "and", "C0031978#ent", "<e2>", "given", "intravenously", "."], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0031978", "name": "C0031978#ent", "pos": [25, 26]}}
{"token": ["C0024796#ent", "<e1>", "MFS", ",", "OMIM", "#", "154700", ")", "is", "a", "C0410787#ent", "<e2>", "clinically", "presenting", "with", "cardinal", "features", "of", "skeletal", ",", "ocular", ",", "and", "cardiovascular", "systems"], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0410787", "name": "C0410787#ent", "pos": [10, 11]}}
{"token": ["Stable", "cell", "surface", "presentation", "of", "MHC", "class", "I", "molecules", "active", "transport", "C0030956#ent", "<e1>", "the", "endoplasmic", "reticulum", "products", "of", "two", "genes", ",", "TAP1", "and", "C1704920#ent", "<e2>", ",", "which", "are", "maped", "in", "the", "MHC", "class", "II", "region"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704920", "name": "C1704920#ent", "pos": [23, 24]}}
{"token": ["Specifically", "anti-LMP2", "and", "LMP7", "mAb", "generated", "from", "BALB/c", "mice", "immunized", "with", "specific", "C0030956#ent", "<e1>", ",", "and", "anti-TAP1", "and", "C1704920#ent", "<e2>", "mAb", "from", "BALB/c", "mice", "immunized", "with", "respective", "recombinant", "proteins"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704920", "name": "C1704920#ent", "pos": [18, 19]}}
{"token": ["C0027021#ent", "<e1>", "was", "prepared", "from", "C1417245#ent", "<e2>", "by", "reduction", "with", "dithiothreitol", "and", "modification", "with", "iodoacetamide", ",", "and", "the", "molecular", "shapes", "the", "holo-", "and", "were", "determined", "by", "analytical", "ultracentrifugation"], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417245", "name": "C1417245#ent", "pos": [5, 6]}}
{"token": ["We", "report", "here", "that", "deferoxamine", "also", "inhibits", "reactions", "catalyzed", "by", "the", "C0027021#ent", "<e1>", "of", "phagocytes", ",", "i.e.", ",", "C1417245#ent", "<e2>", "(", "MPO", ")", "and", "eosinophil", "peroxidase", "EPO", ")", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417245", "name": "C1417245#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "priming", "phosphorylation", "of", "the", "C1426344#ent", "<e1>", "binding", "site", "SPAR", "by", "C1332735#ent", "<e2>", ",", "followed", "by", "C1426344#ent", "<e1>", "recruitment", "and", "SPAR", "phosphorylation-degradation", ",", "constitutes", "a", "molecular", "pathway", "neuronal", "homeostatic", "during", "chronically", "elevated", "activity", "."], "h": {"id": "C1426344", "name": "C1426344#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332735", "name": "C1332735#ent", "pos": [12, 13]}}
{"token": ["In", "this", "randomized", ",", "no", "treatment-controlled", "study", ",", "the", "efficacy", "and", "safety", "of", "oxfendazole", "and", "C0032911#ent", "<e1>", "for", "the", "treatment", "of", "porcine", "C0010678#ent", "<e2>", "were", "evaluated", "in", "16", "naturally", "infected", "pigs", "."], "h": {"id": "C0032911", "name": "C0032911#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0010678", "name": "C0010678#ent", "pos": [22, 23]}}
{"token": ["New", "agents", "cysticercoids", "that", "can", "circulate", "in", "the", "central", "nervous", "system", "C0032911#ent", "<e1>", ",", "albendazole", ")", "have", "greatly", "improved", "the", "prognosis", "of", "C0010678#ent", "<e2>", "."], "h": {"id": "C0032911", "name": "C0032911#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0010678", "name": "C0010678#ent", "pos": [22, 23]}}
{"token": ["Hantaan", "virus", "C0020538#ent", "<e1>", ")", "is", "an", "important", "cause", "of", "hemorrhagic", "fever", "renal", "syndrome", "C0019101#ent", "<e2>", ")", "in", "Korea", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019101", "name": "C0019101#ent", "pos": [14, 15]}}
{"token": ["Other", "therapies", ",", "such", "as", "pyridoxine", "alone", ",", "metoclopramide", ",", "C0700478#ent", "<e1>", "and", "the", "corticosteroids", "may", "be", "beneficial", "in", "managing", "C0132326#ent", "<e2>", "."], "h": {"id": "C0700478", "name": "C0700478#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0132326", "name": "C0132326#ent", "pos": [20, 21]}}
{"token": ["Aldose", "reductase", "ALR2", ")", "is", "the", "first", "and", "rate", "limiting", "enzyme", "of", "this", "pathway", "and", "recent", "studies", "have", "suggested", "that", "polymorphisms", "in", "and", "around", "the", "C0079429#ent", "<e1>", "are", "associated", "with", "development", "of", "C2827469#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C2827469", "name": "C2827469#ent", "pos": [32, 33]}}
{"token": ["Calpains", "(", "C0006784#ent", "<e1>", "have", "evolved", "by", "gene", "fusion", "events", "involving", "calmodulin-like", "genes", "C1333187#ent", "<e2>", "other", "sequences", "of", "unknown", "origin", "."], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333187", "name": "C1333187#ent", "pos": [13, 14]}}
{"token": ["C1413682#ent", "<e1>", "is", "characterized", "by", "a", "deficiency", "of", "C1366370#ent", "<e2>", "fibrinogen", "which", "is", "not", "of", "clinical", "relevance"], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [8, 9]}}
{"token": ["During", "the", "initial", "30", "min", "of", "CCK", "infusion", "the", "bilirubin", ",", "amylase", "and", "C0041236#ent", "<e1>", "outputs", "were", "significantly", "(", "p<0.05", ")", "inhibited", "in", "the", "C1263960#ent", "<e2>", "experiment", "compared", "to", "normoglycemia", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1263960", "name": "C1263960#ent", "pos": [24, 25]}}
{"token": ["The", "PI-3K", "inhibitors", "not", "affect", "MAP", "kinase", "activation", "stimulated", "by", "over-expression", "of", "Sos", ",", "a", "C0669365#ent", "<e1>", "active", "mutant", "of", "C0525678#ent", "<e2>", ",", "or", "a", "C0669365#ent", "<e1>", "active", "mutant", "of", "MEK", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [15, 16]}}
{"token": ["Following", "isoproterenol", "treatment", "mitochondrial", "lipid", "peroxidation", ",", "phosphoslipase", "activity", "C0376261#ent", "<e1>", "and", "calcium", "increased", "significantly", ",", "while", "activities", "of", "tricarboxylic", "acid", "cycle", "C0014442#ent", "<e2>", ",", "C0014442#ent", "<e2>", "of", "respiratory", "chain", "ATP", "production", "showed", "decline", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [22, 23]}}
{"token": ["C0376261#ent", "<e1>", "preserved", "Bryo-induced", "32P-labeled", "PKC-alpha", "indicating", "that", "the", "proteasome", "inhibitor", "activated", "C0014442#ent", "<e2>", "from", "down-regulation", "in", "vivo"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["Partial", "desensitization", "G-6-P", "and", "C0376261#ent", "<e1>", "occurs", "after", "the", "C0014442#ent", "<e2>", "preincubation", "with", "dithiothreitol", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "SAT", "became", "stable", "against", "proteolytic", "attack", "C0764105#ent", "<e1>", "and", "V8", "protease", "forming", "the", "complex", "with", "C0029408#ent", "<e2>", "."], "h": {"id": "C0764105", "name": "C0764105#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [17, 18]}}
{"token": ["With", "regard", "to", "C0250870#ent", "<e1>", ",", "ATF-2", "and", "C1705526#ent", "<e2>", "directly", "bind", "to", "different", "sites", "in", "the", "C0250870#ent", "<e1>", "promoter", "to", "independently", "activate", "its", "transcription", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0250870", "name": "C0250870#ent", "pos": [3, 4]}}
{"token": ["Our", "data", "indicate", "that", "C0250870#ent", "<e1>", "expression", "inversely", "correlates", "with", "mutant", "C1705526#ent", "<e2>", "level", "in", "majority", "of", "cancer", ",", "suggesting", "C0250870#ent", "<e1>", "is", "likely", "a", "C1705526#ent", "<e2>", "target", "gene", "in", "vivo"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0250870", "name": "C0250870#ent", "pos": [4, 5]}}
{"token": ["C0079301#ent", "<e1>", "JEB", ")", "is", "a", "group", "of", "severe", ",", "inherited", "C0162628#ent", "<e2>", "by", "mutations", "in", "the", "genes", "encoding", "laminin", "5", "other", "components", "of", "the", "hemidesmosome", "."], "h": {"id": "C0079301", "name": "C0079301#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [11, 12]}}
{"token": ["All", "of", "these", "effects", "of", "cholesterol", "and", "the", "various", "fatty", "acids", "be", "explained", "by", "the", "effects", "of", "lipids", "in", "C2712370#ent", "<e1>", "the", "size", "of", "the", "regulatory", "pool", "cholesterol", "in", "the", "C0669372#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [30, 31]}}
{"token": ["In", "human", "patients", "with", "C0341009#ent", "<e1>", "PV", ")", "and", "paraneoplastic", "pemphigus", "C1417772#ent", "<e2>", ")", ",", "IgG", "autoantibodies", "desmoglein", "(", "Dsg", ")", "3", "and", "Dsg1", "play", "pathogenic", "roles", "in", "blister", "formation"], "h": {"id": "C0341009", "name": "C0341009#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417772", "name": "C1417772#ent", "pos": [11, 12]}}
{"token": ["It", "exemplifies", "the", "overlap", "between", "C0341009#ent", "<e1>", "C1417772#ent", "<e2>", "and", "the", "pathogenic", "role", "of", "anti-desmoglein", "3", "antibodies", "C1417772#ent", "<e2>", "."], "h": {"id": "C0341009", "name": "C0341009#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417772", "name": "C1417772#ent", "pos": [7, 8]}}
{"token": ["These", "C0012634#ent", "<e1>", "together", "with", "C2717961#ent", "<e2>", "associated", "with", "maternal", "and", "fetal", "mortality", "and", "severe", "long-term", "morbidity", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [5, 6]}}
{"token": ["In", "the", "presence", "of", "NADH", ",", "when", "PRK", "'s", "substrate", "site", "vacant", ",", "ATP", "gamma", "C1456795#ent", "<e1>", "binds", "in", "a", "cooperative", "mode", "(", "Hill", "coefficient", "2.9", ";", "C1705240#ent", "<e2>", "=", "20", "microM", ")", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [27, 28]}}
{"token": ["D-TI", "and", "L-TD", "bind", "to", "Ia", "molecules", "intact", "C1456795#ent", "<e1>", "with", "similar", "C1705240#ent", "<e2>", "values", ",", "5", "x", "10(-8", ")", "M", "and", "3", "x", "10(-8", ")", "M", ",", "respectively", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [12, 13]}}
{"token": ["Bone", "marrow", "cells", "C0600142#ent", "<e1>", "out", "and", "processed", "for", "chromosome", "studies", "C0009262#ent", "<e2>", ",", "hypotonic", ",", "giemsa", ",", "air", "drying", "procedure", "."], "h": {"id": "C0600142", "name": "C0600142#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [11, 12]}}
{"token": ["This", "12-week", "study", "of", "two", "elderly", ",", "depressed", "subjects", "investigated", "the", "effect", "of", "C1879535#ent", "<e1>", "(", "ALCAR", ")", "treatment", "on", "the", "Hamilton", "Depression", "Rating", "Scale", "C2700222#ent", "<e2>", ")", "and", "on", "measures", "of", "high-energy", "phosphate", "membrane", "phospholipid", "metabolism"], "h": {"id": "C1879535", "name": "C1879535#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2700222", "name": "C2700222#ent", "pos": [25, 26]}}
{"token": ["Despite", "its", "efficacy", ",", "the", "use", "of", "C0751039#ent", "<e1>", "is", "limited", "by", "severe", "side", "effects", "mainly", "nephrotoxicity", "and", "C0020538#ent", "<e2>"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["Cyclosporine", "A", "C0751039#ent", "<e1>", ")", ",", "a", "widely", "used", "immunosuppressive", "agent", "causes", "renal", "vasoconstriction", "C0020538#ent", "<e2>"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [14, 15]}}
{"token": ["Further", ",", "we", "show", "that", "ZNF366", "acts", "as", "a", "corepressor", "by", "interacting", "with", "other", "known", "ERalpha", "corepressors", "namely", "C1334904#ent", "<e1>", "and", "CtBP", ",", "to", "inhibit", "expression", "of", "C1704672#ent", "<e2>", "in", "vivo"], "h": {"id": "C1334904", "name": "C1334904#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704672", "name": "C1704672#ent", "pos": [27, 28]}}
{"token": ["More", "specifically", ",", "ATM-dependent", "signaling", "through", "the", "RAF/MEK/ERK", "pathway", "is", "critical", "for", "efficient", "HRR", "and", "for", "radiation-induced", "C0004135#ent", "<e1>", "activation", ",", "suggestive", "of", "a", "regulatory", "feedback", "loop", "C3849574#ent", "<e2>", "and", "C0004135#ent", "<e1>", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [27, 28]}}
{"token": ["H3R2", "methylation", "by", "C1826701#ent", "<e1>", "was", "prevented", "by", "the", "presence", "of", "C3896986#ent", "<e2>", "on", "the", "H3", "tail", "."], "h": {"id": "C1826701", "name": "C1826701#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3896986", "name": "C3896986#ent", "pos": [11, 12]}}
{"token": ["C0038838#ent", "<e1>", "glutamate", "cysteine", "ligase", "catalase", ",", "thioredoxins", "and", "C1136747#ent", "<e2>", ",", "which", "are", "the", "most", "important", "of", "these", "enzymes", ",", "are", "expressed", "in", "lung", "malignancies", "and", "especially", "in", "pleural", "mesothelioma"], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1136747", "name": "C1136747#ent", "pos": [9, 10]}}
{"token": ["This", "study", "was", "designed", "to", "examine", "the", "role", "of", "increased", "renal", "artery", "pressure", "C0079423#ent", "<e1>", ")", "in", "mediating", "escape", "from", "the", "C1563717#ent", "<e2>", "vasopressin", "(", "AVP", ")", "."], "h": {"id": "C0079423", "name": "C0079423#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1563717", "name": "C1563717#ent", "pos": [21, 22]}}
{"token": ["C1142644#ent", "<e1>", "and", "CYP2E1", "were", "incapable", "of", "DDS-NHY", "at", "4", "microM", "C0010980#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [11, 12]}}
{"token": ["The", "C1706554#ent", "<e1>", "determinant", "from", "pMER327/419", "contains", "an", "additional", "potential", "ORF", "(", "C0079941#ent", "<e2>", "located", "between", "merP", "and", "merA", "when", "compared", "with", "the", "archetypal", "Tn501", "."], "h": {"id": "C1706554", "name": "C1706554#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [12, 13]}}
{"token": ["The", "expression", "of", "C1704888#ent", "<e1>", "and", "other", "C0017337#ent", "<e2>", "associated", "with", "malignant", "melanoma", "such", "as", "MCAM/MUC18", ")", "is", "highly", "regulated", "by", "the", "transcription", "factor", "AP-2", "."], "h": {"id": "C1704888", "name": "C1704888#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}}
{"token": ["We", "investigated", "the", "expression", "of", "the", "C1704888#ent", "<e1>", "and", "SCF", "C0017337#ent", "<e2>", "and", "the", "presence", "of", "the", "corresponding", "proteins", "in", "haemopoietic", "tissues", "human", "embryogenesis", "."], "h": {"id": "C1704888", "name": "C1704888#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["Major", "abnormalities", "detected", "in", "19", "which", "included", "C0007282#ent", "<e1>", "nine", ")", ",", "internal", "carotid", "occlusion", "seven", ")", ",", "C1290398#ent", "<e2>", "two", ")", ",", "and", "cerebral", "angioma", "one", ")", "."], "h": {"id": "C0007282", "name": "C0007282#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1290398", "name": "C1290398#ent", "pos": [18, 19]}}
{"token": ["Removal", "of", "the", "platinum", "complex(es", ")", "from", "the", "inactivated", "C0027203#ent", "<e1>", "by", "treatment", "with", "C0700086#ent", "<e2>", "Naddtc", ")", "which", "reverses", "methionine", "but", "not", "cysteine", "binding", "restores", "most", "of", "the", "activity", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0700086", "name": "C0700086#ent", "pos": [14, 15]}}
{"token": ["The", "increase", "in", "C2346918#ent", "<e1>", "in", "the", "intraperitoneal", "fluids", "observed", "among", "cases", "of", "early", "pregnancy", "C0003615#ent", "<e2>", "ovarian", "hyperstimulation", "syndrome", "OHSS", ")", "."], "h": {"id": "C2346918", "name": "C2346918#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003615", "name": "C0003615#ent", "pos": [15, 16]}}
{"token": ["Diagnosis", "was", "accomplished", "on", "the", "second", "baby", "and", "required", "several", "biochemical", "and", "histological", "studies", "in", "order", "to", "rule", "out", "both", "C0751950#ent", "<e1>", "the", "most", "common", "C0027877#ent", "<e2>", "neonatal", "onset", "."], "h": {"id": "C0751950", "name": "C0751950#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0027877", "name": "C0027877#ent", "pos": [25, 26]}}
{"token": ["Scanning", "transmission", "electron", "microscopic", "images", "of", "the", "intact", "complex", "(", "E1E2E3", ")", ",", "the", "C0058087#ent", "<e1>", "E2E3", ")", "subcomplex", ",", "and", "the", "E2", "core", "C0027203#ent", "<e2>", "appear", "as", "cubic", "particles", "various", "orientations", "."], "h": {"id": "C0058087", "name": "C0058087#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [24, 25]}}
{"token": ["The", "C2744579#ent", "<e1>", "action", "was", "not", "influenced", "by", "the", "presence", "of", "either", "C1412179#ent", "<e2>", "of", "an", "C2744579#ent", "<e1>", "regenerating", "system", "whereas", "the", "AMP", "action", "was", "increased", "by", "the", "regenerating", "system"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [12, 13]}}
{"token": ["Beta-N-Methylamino-L-alanine", "(", "BMAA", ")", "and", "beta-N-oxalylamino-L-alanine", "(", "C1422492#ent", "<e1>", ")", "are", "chemically", "related", "C0243046#ent", "<e2>", "in", "the", "seeds", "of", "Cycas", "circinalis", "Lathyrus", "sativus", "respectively", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [13, 14]}}
{"token": ["Capsaicin", "deafferentation", "abolished", "the", "peripheral", "effects", "both", "C2927149#ent", "<e1>", "antagonists", ",", "suggesting", "that", "these", "C0035064#ent", "<e2>", "modulate", "food", "intake", "acting", "on", "CB1", "receptors", "on", "capsaicin-sensitive", "sensory", "terminals", "."], "h": {"id": "C2927149", "name": "C2927149#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}}
{"token": ["Pharmacologic", "therapies", "currently", "available", "to", "address", "individual", "CVD", "risk", "factors", "and", "others", "are", "being", "evaluated", ",", "including", "C2927149#ent", "<e1>", "inhibitors", "of", "peroxisome", "proliferator-activated", "receptor", "subtypes", "alpha", "gamma", ",", "and", "several", "C0035064#ent", "<e2>", "that", "modulate", "the", "activity", "of", "glucagon-like", "peptide-1"], "h": {"id": "C2927149", "name": "C2927149#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [30, 31]}}
{"token": ["Combined", "TSA", "and", "AzadC", "treatment", "increased", "Sp1", "binding", "to", "the", "endogenous", "C1328053#ent", "<e1>", "promoter", "but", "decreased", "the", "association", "between", "C1333891#ent", "<e2>", "and", "Sp1", "in", "HeLa", "cells"], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [19, 20]}}
{"token": ["Short-", "and", "long-term", "Abeta", "treatment", "showed", "opposite", "effects", "on", "C0248868#ent", "<e1>", "suggesting", "that", "long-term", "changes", "are", "an", "adaptation", "to", "the", "C0211705#ent", "<e2>", "early", "down-regulation", "."], "h": {"id": "C0248868", "name": "C0248868#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [20, 21]}}
{"token": ["When", "soluble", "C0248868#ent", "<e1>", "autophosphorylated", "was", "incubated", "with", "PSDs", ",", "the", "C0211705#ent", "<e2>", "was", "precipitated", "by", "centrifugation", ",", "indicating", "that", "the", "soluble", "C0211705#ent", "<e2>", "associated", "with", "and", "formed", "a", "PSD-CaM", "kinase", "II", "complex", "."], "h": {"id": "C0248868", "name": "C0248868#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [11, 12]}}
{"token": ["Three", "large", "pedigrees", "of", "German", "descent", "autosomal", "dominant", "pure", "\"", "familial", "spastic", "paraplegia", "C1705593#ent", "<e1>", ")", "were", "characterized", "clinically", "and", "C1516876#ent", "<e2>", "."], "h": {"id": "C1705593", "name": "C1705593#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [20, 21]}}
{"token": ["Size", "exclusion", "chromatography", "circular", "dichroism", "C1705969#ent", "<e1>", ")", ",", "and", "light", "scattering", "measurements", "indicated", "that", "C1333928#ent", "<e2>", "prevented", "alpha", "B-crystallin", "heat-induced", "structural", "changes", "and", "high", "molecular", "weight", "HMW", ")", "aggregation", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333928", "name": "C1333928#ent", "pos": [15, 16]}}
{"token": ["She", "was", "diagnosed", "as", "C0036202#ent", "<e1>", "steroid", "therapy", "with", "30", "mg", "C0032950#ent", "<e2>", "."], "h": {"id": "C0036202", "name": "C0036202#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [11, 12]}}
{"token": ["Both", "statistical", "approaches", "interesting", "differentially", "expressed", "C0086376#ent", "<e1>", "between", "healthy", "and", "C0013447#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013447", "name": "C0013447#ent", "pos": [11, 12]}}
{"token": ["A", "third", "group", "including", "Coch-5B2", "and", "an", "ear-specific", "connexin", ",", "comprises", "C0086376#ent", "<e1>", "whose", "human", "equivalents", "are", "candidates", "to", "account", "for", "C0013447#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013447", "name": "C0013447#ent", "pos": [21, 22]}}
{"token": ["The", "C1705002#ent", "<e1>", "data", "were", "correlated", "with", "BCL2", "gene", "rearrangement", "by", "C1138393#ent", "<e2>", "and", "long-distance", "polymerase", "chain", "reaction", "approaches", "."], "h": {"id": "C1705002", "name": "C1705002#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1138393", "name": "C1138393#ent", "pos": [11, 12]}}
{"token": ["C0812201#ent", "<e1>", "and", "Ets-2", "both", "induce", "C1415619#ent", "<e2>", "promoter", "activity", "however", ",", "Ets-2", "was", "a", "more", "potent", "transactivator", "of", "C1415619#ent", "<e2>", "in", "macrophages", "."], "h": {"id": "C0812201", "name": "C0812201#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [6, 7]}}
{"token": ["In", "both", "differentiated", "hippocampal", "neurons", "and", "neuroblastoma", "SH-SY5Y", "cells", "we", "found", "that", "these", "two", "C0991617#ent", "<e1>", "not", "only", "activated", "C2350345#ent", "<e2>", ",", "but", "conversely", "greatly", "reduced", "the", "activating", "Ser/Thr", "phosphorylation", "Akt", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [19, 20]}}
{"token": ["However", ",", "all", "three", "C0991617#ent", "<e1>", "increased", "cell", "AMP-to-ATP", "ratio", "and", "stimulated", "C2350345#ent", "<e2>", ",", "making", "it", "likely", "that", "the", "latter", "pathway", "plays", "an", "important", "role", "in", "the", "glucose", "transport", "response"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [12, 13]}}
{"token": ["Molecular", "targets", "these", "C0991617#ent", "<e1>", "have", "recently", "been", "revealed", ";", "C2350345#ent", "<e2>", "AMPK", ")", "for", "metformin", "and", "adiponectin", ",", "while", "PPAR", "gamma", "TZDs", "which", "induce", "gene", "expression", "adipocyte", "glycerol", "kinase", "adiponectin", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [10, 11]}}
{"token": ["Respiratory", "syncytial", "C3640224#ent", "<e1>", "CTL", ")", "showed", "strong", "C1839259#ent", "<e2>", "(", "but", "not", "Dd)-restricted", "recognition", "of", "the", "22", "K", "protein", "."], "h": {"id": "C3640224", "name": "C3640224#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [8, 9]}}
{"token": ["The", "presence", "of", "anticadiolipin", "antibodies", "C1412125#ent", "<e1>", ")", "has", "been", "associated", "with", "C1096458#ent", "<e2>"], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1096458", "name": "C1096458#ent", "pos": [12, 13]}}
{"token": ["Intraventricular", "shunts", "ventriculostomy", "are", "frequently", "employed", "with", "acceptable", "risk-to-benefit", "ratios", "in", "the", "treatment", "of", "various", "C1456542#ent", "<e1>", "while", "humanized", "antibodies", "currently", "used", "in", "clinical", "trials", "brain", "diseases", "as", "C0026769#ent", "<e2>", "lymphoma", "."], "h": {"id": "C1456542", "name": "C1456542#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [28, 29]}}
{"token": ["The", "proinflammatory", "cytokines", "interleukin-1beta", "IL-1beta", ")", "and", "tumor", "necrosis", "factor-alpha", "TNFalpha", ")", "are", "produced", "intracerebrally", "in", "C1456542#ent", "<e1>", "as", "trauma", ",", "ischemia", ",", "meningitis", ",", "and", "C0026769#ent", "<e2>"], "h": {"id": "C1456542", "name": "C1456542#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [26, 27]}}
{"token": ["Recently", ",", "in", "Mackay", "Memorial", "Hospital", "we", "have", "encountered", "in", "series", "three", "pediatric", "cases", "with", "mucopolysaccharidoses", "(", "one", "C0085131#ent", "<e1>", "and", "two", "C1415882#ent", "<e2>", "."], "h": {"id": "C0085131", "name": "C0085131#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1415882", "name": "C1415882#ent", "pos": [22, 23]}}
{"token": ["Hepatic", "C0919425#ent", "<e1>", "was", "only", "induced", "in", "fish", "exposed", "to", "highest", "C1418288#ent", "<e2>", "126", "dose", ";", "protein", "induction", "at", "3", "d", "post-injection", "and", "persisted", "for", "up", "to", "21", "days", "."], "h": {"id": "C0919425", "name": "C0919425#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418288", "name": "C1418288#ent", "pos": [11, 12]}}
{"token": ["Cell", "anchorage", "adhesion", "to", "the", "C3889469#ent", "<e1>", "substrates", "was", "required", "for", "HGF-induced", "C1565427#ent", "<e2>", "activation", ",", "since", "HGF", "failed", "to", "trigger", "tyrosine", "phosphorylation", "C1565427#ent", "<e2>", "in", "suspended", "cells", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [12, 13]}}
{"token": ["These", "signals", "are", "triggered", "by", "interactions", "between", "integrin", "and", "the", "C3889469#ent", "<e1>", "and", "involve", "tyrosine", "phosphorylation", "specific", "proteins", ",", "including", "focal", "adhesion", "kinase", "C1565427#ent", "<e2>", ")", "and", "paxillin", ",", "and", "the", "assembly", "of", "focal", "adhesions", "actin", "bundles"], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [23, 24]}}
{"token": ["The", "three", "groups", "were", "well", "matched", "for", "age", ",", "sex", ",", "C0011847#ent", "<e1>", ",", "smoking", "history", "previous", "surgery", "and", "the", "proportion", "with", "C0030193#ent", "<e2>", "tissue", "necrosis"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [22, 23]}}
{"token": ["We", "are", "reporting", "a", "case", "of", "a", "68-year-old", "woman", "with", "known", "liver", "cirrhosis", "C0011847#ent", "<e1>", "who", "presented", "with", "C0030193#ent", "<e2>", "erythematous", "swelling", "of", "the", "right", "leg"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [18, 19]}}
{"token": ["We", "believe", "that", "HPLC-purified", "peptides", "eluted", "from", "I-Abm12", "molecules", "from", "C0162832#ent", "<e1>", "can", "potentially", "provide", "insight", "on", "the", "C1413096#ent", "<e2>"], "h": {"id": "C0162832", "name": "C0162832#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [18, 19]}}
{"token": ["In", "patients", "receiving", "oral", "C0021400#ent", "<e1>", "the", "levels", "of", "C3814419#ent", "<e2>", "and", "7OHFLU", "were", "significantly", "higher", "than", "levels", "of", "C0021400#ent", "<e1>", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3814419", "name": "C3814419#ent", "pos": [9, 10]}}
{"token": ["Rat", "pineal", "hydroxyindole-O-methyltransferase", "C1848322#ent", "<e1>", ";", "EC", "2.1.1.4", ")", "was", "purified", "by", "affinity", "chromatography", "an", "C3887563#ent", "<e2>"], "h": {"id": "C1848322", "name": "C1848322#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887563", "name": "C3887563#ent", "pos": [15, 16]}}
{"token": ["Cells", "transmigrating", "to", "the", "H4R", "agonist", ",", "but", "not", "C1439351#ent", "<e1>", ",", "were", "skewed", "toward", "a", "CD4", "cell", "expressing", "C1334114#ent", "<e2>", "and", "intracellular", "FoxP3", "."], "h": {"id": "C1439351", "name": "C1439351#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334114", "name": "C1334114#ent", "pos": [19, 20]}}
{"token": ["Opial", "contains", "50", "%", "morphine", "HCl", "and", "other", "opioids", "such", "as", "codeine", ",", "C0039746#ent", "<e1>", ",", "papaverine", ",", "and", "C1450474#ent", "<e2>", "etc", "."], "h": {"id": "C0039746", "name": "C0039746#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1450474", "name": "C1450474#ent", "pos": [19, 20]}}
{"token": ["Functions", "of", "the", "porins", "OmpF", ",", "C0755857#ent", "<e1>", ",", "and", "PhoE", "from", "Escherichia", "coli", "K12", "analyzed", "at", "various", "C1705397#ent", "<e2>", "."], "h": {"id": "C0755857", "name": "C0755857#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [18, 19]}}
{"token": ["In", "the", "ileum", "strip", "of", "control", "rats", "there", "was", "a", "significant", "age-related", "decline", "C1412122#ent", "<e1>", ",", "maximal", "density", "3H-QNB", "binding", "sites", "(", "Bmax", ")", "and", "C0124604#ent", "<e2>", "."], "h": {"id": "C1412122", "name": "C1412122#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [25, 26]}}
{"token": ["The", "platelet", "vasodilator-stimulated", "phosphoprotein", "C1421428#ent", "<e1>", ")", "phosphorylation", "test", "a", "new", "platelet", "function", "assay", "to", "determine", "responsiveness", "to", "C0070166#ent", "<e2>", "."], "h": {"id": "C1421428", "name": "C1421428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0070166", "name": "C0070166#ent", "pos": [18, 19]}}
{"token": ["The", "enzyme", "was", "free", "of", "aspartate", "transaminase", "of", "C0949643#ent", "<e1>", "apparent", "K(m", ")", "values", "for", "the", "C0046494#ent", "<e2>", "smaller", "than", "those", "for", "the", "corresponding", "amino", "acids"], "h": {"id": "C0949643", "name": "C0949643#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0046494", "name": "C0046494#ent", "pos": [16, 17]}}
{"token": ["The", "acidification", "was", "inhibited", "by", "C0082444#ent", "<e1>", "and", "by", "the", "Na+/H+", "antiporter", "inhibitors", ",", "C0002502#ent", "<e2>", "and", "methylisobutylamiloride", ",", "but", "pertussis", "toxin", "treatment", "had", "no", "effect", "quinpirole-induced", "extracellular", "acidification", "."], "h": {"id": "C0082444", "name": "C0082444#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "effects", "of", "C1416790#ent", "<e1>", "C0678941#ent", "<e2>", "protein", "expression", "different", "tissues", ",", "we", "screened", "C1416790#ent", "<e1>", "C0678941#ent", "<e2>", "LAMP-2", "protein", "deficiency", "the", "skeletal", "muscle", "nine", "unrelated", "patients", "with", "hypertrophic", "cardiomyopathy", "vacuolar", "myopathy"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416790", "name": "C1416790#ent", "pos": [5, 6]}}
{"token": ["Mutations", "in", "the", "C0021699#ent", "<e1>", "destabilize", "Tom20", ",", "or", "deletion", "of", "C3890185#ent", "<e2>", ",", "prevent", "Tom20", "from", "functioning", "as", "a", "receptor", "for", "protein", "import", "mitochondria", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3890185", "name": "C3890185#ent", "pos": [11, 12]}}
{"token": ["Estrogens", "and", "progestagens", "exert", "positive", "effects", "on", "some", "general", "diseases", "iron", "deficiency", "anemia", ",", "C0033046#ent", "<e1>", "intermenstrual", "migraine", "akne", ",", "seborrhoea", ",", "hirsutism", ",", "C4083212#ent", "<e2>", "slerodermia", ",", "rheumatoid", "arthritis", "osteoporosis", "and", "depressive", "disorders"], "h": {"id": "C0033046", "name": "C0033046#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4083212", "name": "C4083212#ent", "pos": [24, 25]}}
{"token": ["We", "investigated", "the", "effects", "of", "omeprazole", "or", "C2348248#ent", "<e1>", "on", "peptic", "ulcer", "healing", ",", "eradication", "of", "Helicobacter", "pylori", "C1704665#ent", "<e2>", ")", "and", "abdominal", "symptoms"], "h": {"id": "C2348248", "name": "C2348248#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [18, 19]}}
{"token": ["Sterilizing", "effect", "of", "C2348248#ent", "<e1>", "is", "reported", "to", "be", "the", "direct", "attack", "C1704665#ent", "<e2>", "electron", "microscopic", "findings", "."], "h": {"id": "C2348248", "name": "C2348248#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [12, 13]}}
{"token": ["Either", "C2348248#ent", "<e1>", "or", "omeprazole", "combined", "with", "antibiotics", "are", "effective", "in", "eradicating", "C1704665#ent", "<e2>", "."], "h": {"id": "C2348248", "name": "C2348248#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [12, 13]}}
{"token": ["At", "the", "highest", "dose", "administered", ",", "C1610919#ent", "<e1>", "and", "fenofibrate", "reduced", "very", "low-density", "lipoprotein", "cholesterol", "whereas", ",", "C0289313#ent", "<e2>", "increased", "very", "low-density", "lipoprotein", "cholesterol"], "h": {"id": "C1610919", "name": "C1610919#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [17, 18]}}
{"token": ["At", "higher", "concentrations", ",", "the", "four", "detergents", "were", "inhibitory", "for", "mitochondrial", "oxidations", "the", "order", ":", "C4048272#ent", "<e1>", "greater", "than", "DOC", "greater", "than", "cholate", "greater", "than", "C0041420#ent", "<e2>", "80", "."], "h": {"id": "C4048272", "name": "C4048272#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041420", "name": "C0041420#ent", "pos": [25, 26]}}
{"token": ["In", "a", "semi-quantitative", "activity", "assay", ",", "it", "is", "shown", "that", "gp17", "is", "a", "functional", ",", "C0059946#ent", "<e1>", "in", "spite", "of", "some", "structural", "differences", "related", "to", "C0812382#ent", "<e2>", "properties", ")", "."], "h": {"id": "C0059946", "name": "C0059946#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [25, 26]}}
{"token": ["This", "complex", "was", "the", "substrate", "for", "the", "C0059946#ent", "<e1>", "binding", "of", "a", "third", "C0812382#ent", "<e2>", "the", "core", "binding", "factor", "CBF", "."], "h": {"id": "C0059946", "name": "C0059946#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [13, 14]}}
{"token": ["C1531872#ent", "<e1>", "ERU", ")", "is", "an", "C0029400#ent", "<e2>", "high", "similarity", "to", "uveitis", "in", "man", "."], "h": {"id": "C1531872", "name": "C1531872#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029400", "name": "C0029400#ent", "pos": [6, 7]}}
{"token": ["In", "developing", "countries", "mild", "to", "moderate", "enteropathies", "in", "children", "with", "C0401151#ent", "<e1>", "growth", "failure", "assumed", "to", "be", "caused", "by", "tropical", "sprue", "persistent", "infections", "or", "C0162429#ent", "<e2>", "with", "bacterial", "overgrowth"], "h": {"id": "C0401151", "name": "C0401151#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [24, 25]}}
{"token": ["Our", "study", "also", "suggests", "that", "C0017373#ent", "<e1>", "from", "bromocriptine", "to", "pergolide", "improves", "C0028734#ent", "<e2>", ",", "thereby", "improving", "sleep", "status", "patients", "with", "Parkinson's", "disease"], "h": {"id": "C0017373", "name": "C0017373#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028734", "name": "C0028734#ent", "pos": [12, 13]}}
{"token": ["Microsequencing", "of", "five", "C0030956#ent", "<e1>", "derived", "from", "purified", "p60", "indicates", "that", "p60", "is", "C2346628#ent", "<e2>", "LSP1", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2346628", "name": "C2346628#ent", "pos": [13, 14]}}
{"token": ["In", "vivo", "we", "found", "that", "MHV", "C3812695#ent", "<e1>", "was", "expressed", "during", "C0149512#ent", "<e2>", "also", "during", "persistence", ",", "particularly", "in", "the", "lungs", "of", "infected", "mice", "."], "h": {"id": "C3812695", "name": "C3812695#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [11, 12]}}
{"token": ["In", "a", "subgroup", "analysis", ",", "patients", "with", "C0085077#ent", "<e1>", "had", "higher", "values", "for", "salivary", "IgA", "C1706005#ent", "<e2>", "than", "patients", "without", "C0085077#ent", "<e1>", "."], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [15, 16]}}
{"token": ["These", "results", "demonstrate", "a", "novel", "role", "for", "C1822691#ent", "<e1>", "in", "inflammation", "and", "C0011849#ent", "<e2>", "."], "h": {"id": "C1822691", "name": "C1822691#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [12, 13]}}
{"token": ["The", "important", "role", "of", "AT", "in", "C0010927#ent", "<e1>", "and", "sepsis", "is", "the", "basis", "for", "considering", "C0003438#ent", "<e2>", "concentrates", "as", "an", "additional", "therapeutic", "modality"], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [15, 16]}}
{"token": ["C0010927#ent", "<e1>", "was", "treated", "according", "to", "laboratory", "parameters", "by", "supply", "of", "C0003438#ent", "<e2>", "(", "AT", ")", "III", ",", "fresh", "frozen", "plasma", "prothrombin", "complex", "concentrates", "PPSB", ")", "and", "continuous", "aprotinin", "IE/h", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [11, 12]}}
{"token": ["The", "data", "that", "demonstrate", "a", "high", "predisposition", "for", "head-injured", "individuals", "to", "develop", "C0010927#ent", "<e1>", "serve", "as", "a", "the", "rationale", "for", "therapeutic", "intervention", "coagulation", "protease", "inhibitors", "especially", "C0003438#ent", "<e2>", "(", "AT", ")", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [26, 27]}}
{"token": ["Although", "cultivation", "of", "C1418789#ent", "<e1>", "the", "presence", "of", "exogenous", "dibutyryl", "cyclic", "C4285220#ent", "<e2>", "does", "inhibit", "replication", "and", "produce", "morphologic", "alterations", ",", "similar", "effects", "are", "produced", "by", "sodium", "butyrate", "."], "h": {"id": "C1418789", "name": "C1418789#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4285220", "name": "C4285220#ent", "pos": [11, 12]}}
{"token": ["The", "t(8;13", ")", "translocation", "found", "in", "a", "rare", "type", "of", "stem", "cell", "myeloproliferative", "disorder", "a", "constitutively", "activated", "C1421249#ent", "<e1>", "N-terminal", "sequence", "by", "the", "C3273671#ent", "<e2>", "gene", "linked", "to", "the", "FGFR1", "kinase", "domain", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3273671", "name": "C3273671#ent", "pos": [23, 24]}}
{"token": ["They", "were", "isolated", "from", "gut", "infections", "Escherichia", "coli", "salmonellae", ")", ",", "C0024894#ent", "<e1>", "(", "E.", "coli", "Staphylococcus", "aureus", "Streptococcus", "uberis", "S.", "agalactiae", ",", "S.", "dysgalactiae", "and", "C0035204#ent", "<e2>", "Mannheimia", "haemolytica", "Pasteurella", "multocida", "Haemophilus", "somnus", "."], "h": {"id": "C0024894", "name": "C0024894#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [26, 27]}}
{"token": ["The", "major", "benefits", ",", "observed", "experimentally", ",", "of", "maintaining", "optimal", "Se", "intakes", "include", "minimizing", "the", "incidence", "of", "C0024894#ent", "<e1>", "and", "preventing", "calf", "losses", "associated", "with", "and(or", ")", "C0035204#ent", "<e2>"], "h": {"id": "C0024894", "name": "C0024894#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [27, 28]}}
{"token": ["Purine", "nucleosides", "uridine", "induced", "currents", "in", "oocytes", "expressing", "rat", "SPNT", "(", "C3810553#ent", "<e1>", ")", "or", "human", "SPNT1", "(", "C1420170#ent", "<e2>", ")", "."], "h": {"id": "C3810553", "name": "C3810553#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420170", "name": "C1420170#ent", "pos": [18, 19]}}
{"token": ["Purine", "nucleosides", "uridine", "induced", "currents", "in", "oocytes", "expressing", "rat", "SPNT", "(", "C3810553#ent", "<e1>", ")", "or", "human", "C1420170#ent", "<e2>", "(", "hSPNT1", ")", "."], "h": {"id": "C3810553", "name": "C3810553#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420170", "name": "C1420170#ent", "pos": [16, 17]}}
{"token": ["The", "progesterone", "antagonist", "mifepristone", "RU486", ",", "C1707065#ent", "<e1>", ")", "has", "been", "shown", "to", "exert", "a", "paradoxical", "C0243192#ent", "<e2>", "effect", "on", "postmenopausal", "endometrium"], "h": {"id": "C1707065", "name": "C1707065#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "NTRK1", "mutations", "in", "five", "C0020074#ent", "<e1>", "patients", "and", "one", "less", "typical", "patient", "with", "C0020620#ent", "<e2>", ",", "insensitivity", "to", "pain", "well", "as", "motor-", "and", "sensory", "deficits", "the", "peripheral", "nervous", "system"], "h": {"id": "C0020074", "name": "C0020074#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020620", "name": "C0020620#ent", "pos": [15, 16]}}
{"token": ["At", "present", "there", "are", "no", "data", "favoring", "the", "use", "of", "an", "ultra", "low-dose", "diuretic", "such", "as", "12.5", "mg", "C0020261#ent", "<e1>", ",", "unless", "there", "is", "coexisting", "prediabetes", "or", "C0018099#ent", "<e2>", "."], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [27, 28]}}
{"token": ["Other", "than", "the", "patients", "'", "genetic", "predispositions", "C0011854#ent", "<e1>", "risk", "factors", "the", "therapy", "are", "mentioned", "as", "obesity", ",", "C0154251#ent", "<e2>", "hypertension", "and", "absence", "of", "physical", "activity"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0154251", "name": "C0154251#ent", "pos": [18, 19]}}
{"token": ["The", "effects", "of", "treatment", "on", "plasma", "total", "triglyceride", "total", "cholesterol", "and", "plasma", "postheparin", "lipase", "activities", "have", "not", "been", "evaluated", "in", "C0011854#ent", "<e1>", "NIDD", ")", "subjects", "without", "a", "coexisting", "C0154251#ent", "<e2>"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0154251", "name": "C0154251#ent", "pos": [28, 29]}}
{"token": ["4", "Approximately", "45", "-", "50", "%", "of", "the", "administered", "dose", "eliminated", "in", "the", "urine", "as", "unchanged", "C1254351#ent", "<e1>", "or", "as", "sulphone", "or", "C0038742#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038742", "name": "C0038742#ent", "pos": [22, 23]}}
{"token": ["Antiarrhythmic", "activity", "an", "indirect", "mechanism", ",", "related", "to", "the", "antiplatelet", "properties", "of", "the", "C1254351#ent", "<e1>", ",", "or", "by", "metabolites", "of", "C0038742#ent", "<e2>", ",", "remains", "a", "possibility", "requiring", "further", "investigation", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038742", "name": "C0038742#ent", "pos": [20, 21]}}
{"token": ["These", "preliminary", "results", "suggest", "that", "C0070122#ent", "<e1>", "could", "be", "a", "choice", "in", "the", "pharmacologic", "treatment", "C0235480#ent", "<e2>"], "h": {"id": "C0070122", "name": "C0070122#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [15, 16]}}
{"token": ["Intriguingly", ",", "a", "major", "protein", "copurifying", "C1413858#ent", "<e1>", "and", "P450c21", "was", "identified", "as", "3beta-hydroxysteroid", "dehydrogenase", "(", "C3489584#ent", "<e2>", ")", "which", "was", "subsequently", "found", "not", "to", "directly", "bind", "Fld", "Sepharose", "."], "h": {"id": "C1413858", "name": "C1413858#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3489584", "name": "C3489584#ent", "pos": [16, 17]}}
{"token": ["2", ",", "gilts", "were", "immunized", "against", "C1706512#ent", "<e1>", "(", "n", "=", "35", ")", "or", "C0304925#ent", "<e2>", "(", "n", "=", "35", ")", "at", "35", "+", "/-", "1", "d", "of", "age", "."], "h": {"id": "C1706512", "name": "C1706512#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0304925", "name": "C0304925#ent", "pos": [14, 15]}}
{"token": ["1", ",", "gilts", "were", "immunized", "against", "C1706512#ent", "<e1>", "(", "n", "=", "12", ")", "or", "C0304925#ent", "<e2>", "(", "n", "=", "12", ")", "at", "92", "+", "/-", "1", "d", "of", "age", "."], "h": {"id": "C1706512", "name": "C1706512#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0304925", "name": "C0304925#ent", "pos": [14, 15]}}
{"token": ["Further", "urgent", "indications", "are", "severe", "C0019360#ent", "<e1>", "the", "trunk", "and", "on", "the", "extremities", ",", "C0019360#ent", "<e1>", "immunosuppressed", "patients", "and", "in", "patients", "with", "severe", "C0011615#ent", "<e1>", "severe", "ekzema", "."], "h": {"id": "C0019360", "name": "C0019360#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [23, 24]}}
{"token": ["The", "first", "two", "C0149931#ent", "<e1>", "genes", "discovered", "in", "families", "with", "C1832903#ent", "<e2>", "encode", "ion", "transporters", "emphasising", "that", "dysfunction", "of", "ion", "transport", "be", "an", "important", "factor", "in", "C0149931#ent", "<e1>", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C1832903", "name": "C1832903#ent", "pos": [10, 11]}}
{"token": ["We", "hypothesize", "that", "the", "mechanisms", "of", "sporadic", "hemiplegic", "C0149931#ent", "<e1>", "probably", "lie", "at", "a", "cellular", "level", "similiar", "to", "familial", "C1832903#ent", "<e2>"], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C1832903", "name": "C1832903#ent", "pos": [19, 20]}}
{"token": ["Disabling", "C3897992#ent", "<e1>", "children", "is", "a", "clinical", "subset", "C0263409#ent", "<e2>", "that", "tends", "to", "involve", "deeper", "structures", "and", "progresses", "relentlessly", "."], "h": {"id": "C3897992", "name": "C3897992#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0263409", "name": "C0263409#ent", "pos": [8, 9]}}
{"token": ["Finally", ",", "introduction", "of", "a", "wild-type", "copy", "of", "C1336675#ent", "<e1>", "by", "germline", "transformation", "the", "variant", "strain", "confers", "the", "wild-type", "C1420445#ent", "<e2>", "phenotype", "."], "h": {"id": "C1336675", "name": "C1336675#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420445", "name": "C1420445#ent", "pos": [19, 20]}}
{"token": ["The", "negative", "effects", "on", "GC", "on", "GCT", "tenocytes", "cultured", "on", "membrane", "were", "particularly", "evident", "on", "C1705597#ent", "<e1>", "for", "CICP", "(", "-18", "%", ")", "and", "C2700045#ent", "<e2>", "(", "-67", "%", ")", "synthesis", "."], "h": {"id": "C1705597", "name": "C1705597#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2700045", "name": "C2700045#ent", "pos": [24, 25]}}
{"token": ["The", "most", "commonly", "described", "cases", "of", "this", "phenomenon", "concern", "mycobacterial", "(", "C0026916#ent", "<e1>", "M.", "tuberculosis", "infections", ",", "pneumocystodosis", ",", "C0085436#ent", "<e2>", "and", "CMV", "infections"], "h": {"id": "C0026916", "name": "C0026916#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085436", "name": "C0085436#ent", "pos": [19, 20]}}
{"token": ["This", "C0039082#ent", "<e1>", "has", "features", "of", "C0392441#ent", "<e2>", "en", "coup", "de", "sabre", "'", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0392441", "name": "C0392441#ent", "pos": [6, 7]}}
{"token": ["Human", "T", "cell", "lymphotropic", "virus-I", "C0037928#ent", "<e1>", "is", "a", "slowly", "progressive", "C0027765#ent", "<e2>", "by", "inflammatory", "infiltrates", "the", "central", "nervous", "system", "by", "clonal", "expansion", "HTLV-I-reactive", "CD8", "+", "T-cells", "."], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [11, 12]}}
{"token": ["Human", "T-cell", "leukemia/lymphoma", "virus", "type", "I", "type", "II", "HTLV-I/II", ")", "infections", "can", "be", "transfusion", "associated", ",", "leading", "to", "tropical", "paraparesis", "C0037928#ent", "<e1>", "and", "other", "C0027765#ent", "<e2>"], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [20, 21]}, "relation": "related_to", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [24, 25]}}
{"token": ["C0037928#ent", "<e1>", "is", "a", "form", "of", "C0027765#ent", "<e2>", "by", "compression", "of", "the", "spinal", "cord"], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [6, 7]}}
{"token": ["Enhancement", "of", "C1420713#ent", "<e1>", "is", "exhibited", "by", "the", "C0040615#ent", "<e2>", "chlorpromazine", ",", "thiothixene", ",", "thioridazine", ",", "mesoridazine", ",", "and", "metoclopramide", "but", "not", "clozapine", "."], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [8, 9]}}
{"token": ["These", "results", "illustrate", "that", "the", "C1420713#ent", "<e1>", "model", "is", "equally", "sensitive", "to", "typical", "and", "atypical", "C0040615#ent", "<e2>", "and", "reemphasises", "its", "utility", "as", "a", "test", "model", "detecting", "the", "antipsychotic", "potential", "of", "novel", "drugs", "."], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [15, 16]}}
{"token": ["This", "finding", "was", "consistent", "in", "patients", "treated", "with", "C1420713#ent", "<e1>", "alone", "or", "C1420713#ent", "<e1>", "combined", "with", "other", "C0040615#ent", "<e1>", "."], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "mice", "with", "nordihydroguaiaretic", "acid", "10", "to", "90", "mumol/mouse", ")", ",", "a", "C1289971#ent", "<e1>", "also", "inhibited", "the", "induction", "of", "C1422630#ent", "<e2>", "by", "TPA", "."], "h": {"id": "C1289971", "name": "C1289971#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1422630", "name": "C1422630#ent", "pos": [20, 21]}}
{"token": ["Another", "family", "member", "protein", "phosphatase", "5", "C3812280#ent", "<e1>", ")", ",", "contains", "a", "C1421212#ent", "<e2>", "its", "N", "terminus", ",", "which", "has", "been", "suggested", "to", "mediate", "interactions", "with", "other", "proteins", "."], "h": {"id": "C3812280", "name": "C3812280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421212", "name": "C1421212#ent", "pos": [12, 13]}}
{"token": ["A", "truncated", "C3812280#ent", "<e1>", "mutant", "consisting", "only", "of", "its", "C1421212#ent", "<e2>", "as", "a", "dominant", "negative", "C3812280#ent", "<e1>", "that", "enhanced", "serine", "residue", "118", "phosphorylation", "of", "ERalpha", "and", "transactivations", "by", "ERalpha", "and", "ERbeta", "."], "h": {"id": "C3812280", "name": "C3812280#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421212", "name": "C1421212#ent", "pos": [9, 10]}}
{"token": ["However", ",", "22", "%", "of", "the", "children", "had", "+", "1.0", "diopters", "or", "more", "of", "C0020490#ent", "<e1>", "uncovered", "by", "C0004259#ent", "<e2>", "."], "h": {"id": "C0020490", "name": "C0020490#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [18, 19]}}
{"token": ["Although", "there", "is", "limited", "clinical", "data", "the", "effectiveness", "of", "echinocandins", "in", "pediatric", "patients", "with", "documented", "invasive", "C0026946#ent", "<e1>", "this", "case", "report", "that", "combining", "liposomal", "amphotericin", "B", "C0537894#ent", "<e2>", "could", "be", "advantageous", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [16, 17]}, "relation": "may_be_prevented_by", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [26, 27]}}
{"token": ["The", "livers", "from", "a", "patient", "with", "C1415286#ent", "<e1>", "D-glycerate", "dehydrogenase", "deficiency", "and", "one", "with", "an", "undefined", "form", "of", "C0268164#ent", "<e2>", "possibly", "oxalate", "hyperabsorption", ")", "had", "normal", "AGT", "levels", "."], "h": {"id": "C1415286", "name": "C1415286#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [18, 19]}}
{"token": ["In", "both", ",", "C3814419#ent", "<e1>", "was", "25", "%", "or", "less", "and", "in", "one", "C0023381#ent", "<e2>", "was", "greater", "than", "55", "mm", "."], "h": {"id": "C3814419", "name": "C3814419#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023381", "name": "C0023381#ent", "pos": [13, 14]}}
{"token": ["Glucosamine", "synthetase", "the", "first", "C0014442#ent", "<e1>", "in", "glycoprotein", "biosynthesis", "catalysing", "the", "formation", "of", "C0061395#ent", "<e2>", ",", "from", "which", "N-acetylglucosamine", "is", "formed", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0061395", "name": "C0061395#ent", "pos": [13, 14]}}
{"token": ["This", "is", "suggested", "by", "the", "fact", "that", "glucose-6-phosphate", "dehydrogenase", "the", "initiating", "C0014442#ent", "<e1>", "for", "the", "HMPS", ",", "did", "not", "utilize", "C0061395#ent", "<e2>", "as", "a", "substrate", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0061395", "name": "C0061395#ent", "pos": [20, 21]}}
{"token": ["The", "C0014442#ent", "<e1>", "displays", "positive", "homotropic", "cooperativity", "toward", "C0061395#ent", "<e2>", "(", "Hill", "coefficient", "2.1", ",", "pH", "8.8", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0061395", "name": "C0061395#ent", "pos": [8, 9]}}
{"token": ["Glucosamine-6-phosphate", "deaminase", "EC", "3.5.99.6", ")", "is", "an", "C0014442#ent", "<e1>", "catalyzes", "the", "reversible", "conversion", "of", "C0061395#ent", "<e2>", "into", "D-fructose-6-phosphate", "and", "ammonium", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061395", "name": "C0061395#ent", "pos": [14, 15]}}
{"token": ["Conditions", "were", "established", "for", "the", "assay", "of", "three", "nucleolytic", "enzymes", ":", "a", "Mg2+-independent", "C0014241#ent", "<e1>", ",", "a", "Mg2+", "endonuclease", ",", "and", "a", "C1333909#ent", "<e2>", "+", "-dependent", "5'-exonuclease", "in", "Saccharomyces", "cerevisiae", "cell", "extracts"], "h": {"id": "C0014241", "name": "C0014241#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [22, 23]}}
{"token": ["Cleavage", "by", "the", "C0014241#ent", "<e1>", "the", "presence", "of", "divalent", "metal", "ions", ",", "of", "which", "C1333909#ent", "<e2>", "+", "promotes", "most", "efficient", "cleavage", "."], "h": {"id": "C0014241", "name": "C0014241#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [14, 15]}}
{"token": ["During", "the", "discovery", "phase", "C0754659#ent", "<e1>", "was", "optimized", "to", "inhibit", "both", "forms", "of", "C0039602#ent", "<e2>", "5AR", ")", "via", "extensive", "structure", "activity", "relationship", "studies", "the", "cloned", "human", "isozymes", "."], "h": {"id": "C0754659", "name": "C0754659#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039602", "name": "C0039602#ent", "pos": [13, 14]}}
{"token": ["The", "transcription", "factor", "nuclear", "factor-kappaB", "NF-kappaB", ")", "regulates", "a", "large", "number", "of", "C1417679#ent", "<e1>", "involved", "in", "the", "inflammatory", "response", "C0010340#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010340", "name": "C0010340#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "these", "C0039902#ent", "<e1>", "mice", "recapitulate", "features", "of", "astrocytic", "pathology", "in", "C0949664#ent", "<e2>", "and", "implicate", "a", "role", "for", "altered", "astrocyte", "function", "in", "the", "pathogenesis", "of", "these", "disorders", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0949664", "name": "C0949664#ent", "pos": [12, 13]}}
{"token": ["Antigen", "challenge", "immunized", "mice", "induced", "the", "expression", "of", "C1334126#ent", "<e1>", "and", "the", "production", "of", "C0022575#ent", "<e2>", "and", "MIP-2", "proteins"], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022575", "name": "C0022575#ent", "pos": [14, 15]}}
{"token": ["The", "equivalent", "current", "dipole", "(", "C1825023#ent", "<e1>", ")", "of", "the", "C0720099#ent", "<e2>", "MMNm", "was", "located", "in", "the", "auditory", "cortex", "posterior", "to", "that", "for", "the", "frequency", "MMNm", "irrespective", "of", "stimulus", "duration"], "h": {"id": "C1825023", "name": "C1825023#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [10, 11]}}
{"token": ["The", "replication", "profiles", "of", "three", "C0017337#ent", "<e1>", "from", "different", "regions", "of", "chromosome", "X", "ZFX", ",", "XIST", "and", "C2699992#ent", "<e2>", ")", "were", "used", "as", "terms", "of", "reference", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2699992", "name": "C2699992#ent", "pos": [17, 18]}}
{"token": ["To", "select", "polymorphic", "short", "tandem", "repeat", "markers", "X-linked", "nuclear", "protein", "XNP", ")", "C0017337#ent", "<e1>", ",", "genomic", "clones", "contain", "XNP", "gene", "recognized", "by", "homologous", "analysis", "C2699992#ent", "<e2>", "cDNA", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2699992", "name": "C2699992#ent", "pos": [24, 25]}}
{"token": ["C4054127#ent", "<e1>", "treatable", "with", "angiotensin-converting", "enzyme", "inhibition", "or", "angiotensin", "II", "AII", ")", "C0036753#ent", "<e2>"], "h": {"id": "C4054127", "name": "C4054127#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036753", "name": "C0036753#ent", "pos": [12, 13]}}
{"token": ["These", "observations", "demonstrate", "that", "although", "plasma", "C2351517#ent", "<e1>", "a", "phospholipase", "A2", "has", "structural", "properties", "of", "the", "C0023764#ent", "<e2>", "esterases", "."], "h": {"id": "C2351517", "name": "C2351517#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0023764", "name": "C0023764#ent", "pos": [16, 17]}}
{"token": ["We", "have", "discovered", "that", "C1832932#ent", "<e1>", "can", "be", "induced", "by", "glucocorticoids", "(", "C1704697#ent", "<e2>", ")", "and", "that", "this", "regulation", "is", "influenced", "by", "crosstalk", "with", "the", "protein", "kinase", "A", "PKA", ")", "system", "."], "h": {"id": "C1832932", "name": "C1832932#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704697", "name": "C1704697#ent", "pos": [12, 13]}}
{"token": ["Chronic", "treatment", "the", "specific", "C3850099#ent", "<e1>", "sulpiride", "also", "caused", "elevation", "in", "C1414326#ent", "<e2>", "mRNA", "levels", "in", "all", "three", "brain", "regions", "whereas", "the", "specific", "serotonin", "S2", "receptor", "blocker", "cinanserin", ",", "had", "no", "significant", "on", "C1414326#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C3850099", "name": "C3850099#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414326", "name": "C1414326#ent", "pos": [11, 12]}}
{"token": ["The", "structure", "of", "wildtype", "and", "mutant", "5S", "rRNA", "was", "compared", "by", "chemical", "modification", "accessible", "guanosines", "with", "C0064305#ent", "<e1>", "and", "limited", "enzymatic", "digestion", "using", "C0018364#ent", "<e2>", "nuclease", "S1"], "h": {"id": "C0064305", "name": "C0064305#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0018364", "name": "C0018364#ent", "pos": [23, 24]}}
{"token": ["All", "clinical", "symptoms", "relieved", "by", "intravenous", "pulsatile", "administration", "of", "C0360556#ent", "<e1>", "followed", "by", "oral", "prednisone", ",", "resulting", "in", "prolonged", "C0020676#ent", "<e2>", "status", "."], "h": {"id": "C0360556", "name": "C0360556#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [19, 20]}}
{"token": ["C0694884#ent", "<e1>", "represses", "p65-mediated", "transcriptional", "activation", "on", "C1417708#ent", "<e2>", "a", "dose-dependent", "and", "specific", "manner", "."], "h": {"id": "C0694884", "name": "C0694884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [7, 8]}}
{"token": ["The", "C0694884#ent", "<e1>", "encodes", "menin", ",", "a", "nuclear", "protein", "interacting", "JunD/AP1", ",", "Smad3", ",", "C1417708#ent", "<e2>", ",", "and", "other", "proteins", "involved", "in", "transcription", "and", "cell", "growth", "regulation"], "h": {"id": "C0694884", "name": "C0694884#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [14, 15]}}
{"token": ["The", "data", "suggest", "that", "C0081695#ent", "<e1>", "distinct", "from", "all", "other", "C1947941#ent", "<e2>", "of", "B.", "subtilis", "."], "h": {"id": "C0081695", "name": "C0081695#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "C0022661#ent", "<e1>", "does", "not", "appear", "to", "impair", "non-microsomal", "acetylation", "of", "C0033216#ent", "<e2>", ",", "the", "major", "biotransformation", "reaction", "the", "metabolism", "of", "this", "drug", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [12, 13]}}
{"token": ["Acarbose", ",", "losartan", ",", "orlistat", ",", "pravastatin", ",", "C0072970#ent", "<e1>", ",", "and", "hormone", "replacement", "therapy", "associated", "with", "rates", "of", "the", "development", "of", "C0011849#ent", "<e2>", "."], "h": {"id": "C0072970", "name": "C0072970#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [22, 23]}}
{"token": ["A", "quinonoid", "intermediate", "has", "not", "been", "detected", "using", "a", "variety", "of", "kinetic", "and", "spectroscopic", "probes", "for", "the", "wild-type", "or", "mutant", "C0014442#ent", "<e1>", ",", "ruling", "out", "an", "C1412756#ent", "<e2>", "mechanism", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1412756", "name": "C1412756#ent", "pos": [26, 27]}}
{"token": ["This", "C0014442#ent", "<e1>", "catalyzes", "the", "interconversion", "of", "estrone", "(", "C1412756#ent", "<e2>", ")", "to", "the", "biologically", "more", "potent", "estradiol", "(", "E2", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412756", "name": "C1412756#ent", "pos": [9, 10]}}
{"token": ["C0020619#ent", "<e1>", "persisted", "despite", "restoration", "of", "normoprolactinemia", "with", "C0006230#ent", "<e2>"], "h": {"id": "C0020619", "name": "C0020619#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [8, 9]}}
{"token": ["The", "acute", "C0042402#ent", "<e1>", "a", "single", "oral", "dose", "a", "C2923059#ent", "<e2>", "sildenafil", "citrate", "on", "the", "brachial", "artery", "dilatation", "evaluated", "in", "25", "normal", "healthy", "volunteers", "NL", ")", "and", "in", "25", "refractory", "hypertensive", "patients", "(", "RH", ")", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2923059", "name": "C2923059#ent", "pos": [9, 10]}}
{"token": ["Neither", "the", "C1335439#ent", "<e1>", "nor", "the", "dRP-lyase", "activities", "of", "pol", "beta", "affected", "by", "C1826697#ent", "<e2>", "methylation", "."], "h": {"id": "C1335439", "name": "C1335439#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826697", "name": "C1826697#ent", "pos": [13, 14]}}
{"token": ["The", "data", "also", "indicate", "that", "AR", "via", "the", "C1412028#ent", "<e1>", "more", "than", "an", "inducible", "C0007054#ent", "<e2>", "and", "antiporter", "."], "h": {"id": "C1412028", "name": "C1412028#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007054", "name": "C0007054#ent", "pos": [14, 15]}}
{"token": ["One", "C1305923#ent", "<e1>", "is", "the", "C0016016#ent", "<e2>", "of", "230", "amino", "acids", "and", "the", "other", "peptide", "is", "the", "COOH-terminal", "portion", "the", "A", "chain", "of", "plasmin", "consisting", "of", "31", "amino", "acid", "residues", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0016016", "name": "C0016016#ent", "pos": [5, 6]}}
{"token": ["Therefore", ",", "to", "determine", "their", "overall", "contribution", "we", "have", "simultaneously", "examined", "the", "immunohistochemical", "status", "C1334895#ent", "<e1>", ",", "p16", "and", "cyclin", "D1", "analysed", "the", "C0694873#ent", "<e2>", "a", "characterized", "activating", "mutation", "."], "h": {"id": "C1334895", "name": "C1334895#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0694873", "name": "C0694873#ent", "pos": [23, 24]}}
{"token": ["We", "also", "show", "that", "the", "cell", "cycle-regulatory", "defect", "of", "the", "p16INK4a", "duplication", "mutant", "was", "associated", "with", "decreased", "inhibition", "of", "C1334895#ent", "<e1>", "phosphorylation", "even", "though", "it", "retained", "significant", "binding", "to", "C0694873#ent", "<e2>", "."], "h": {"id": "C1334895", "name": "C1334895#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0694873", "name": "C0694873#ent", "pos": [29, 30]}}
{"token": ["This", "study", "has", "failed", "to", "show", "any", "definite", "effect", "of", "C0039832#ent", "<e1>", "on", "the", "course", "of", "human", "C0040896#ent", "<e2>", "at", "the", "doses", "used", "."], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0040896", "name": "C0040896#ent", "pos": [17, 18]}}
{"token": ["On", "the", "other", "hand", ",", "glycation", "and", "altered", "turnover", "of", "C0086376#ent", "<e1>", "play", "also", "an", "important", "role", "in", "the", "development", "of", "C0853897#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0853897", "name": "C0853897#ent", "pos": [21, 22]}}
{"token": ["Benzoate", "(", "IV", "e", "showed", "a", "remarkable", "hypotensive", "and", "bradycardic", "activity", "rats", ",", "whereas", "C0000979#ent", "<e1>", "(", "IV", "a", ")", "showed", "infiltration", "anesthesia", "C0003195#ent", "<e2>", "mice", "slightly", "inferior", "to", "those", "of", "lidocaine", "."], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [23, 24]}}
{"token": ["Because", "the", "calcium", "concentrations", "the", "acetate", "baths", "set", "equal", "to", "that", "of", "the", "control", "bath", "calcium", "complexing", "by", "C0000979#ent", "<e1>", "could", "not", "have", "accounted", "for", "acetate", "'s", "C0003195#ent", "<e2>", "effect", "."], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [27, 28]}}
{"token": ["Reaction", "of", "rat", "liver", "phosphoenolpyruvate", "carboxykinase", "GTP", ":", "oxaloacetate", "carboxy-lyase", "transphosphorylating", ")", ",", "C0042085#ent", "<e1>", "with", "the", "alkylating", "fluorescent", "probe", "C0044039#ent", "<e2>", "1,5-I-AEDANS", ")", ",", "results", "in", "complete", "loss", "of", "enzymatic", "activity"], "h": {"id": "C0042085", "name": "C0042085#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0044039", "name": "C0044039#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "patients", "with", "renal", "insufficiency", "have", "significant", "chronic", "decrements", "in", "GFR", "with", "long-acting", "C0003211#ent", "<e1>", "such", "as", "piroxicam", "and", "C0038792#ent", "<e2>", ",", "but", "not", "with", "short-acting", "ibuprofen"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [15, 16]}, "relation": "structural_class_of", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [21, 22]}}
{"token": ["Exposure", "to", "C0003211#ent", "<e1>", "had", "a", "complex", "effect", "on", "HSP", "gene", "expression", "while", "C0038792#ent", "<e2>", "activated", "the", "stress", "responsive", "HSP70B", "promoter", ",", "sodium", "salicylate", "not", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [2, 3]}, "relation": "structural_class_of", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [13, 14]}}
{"token": ["Four", "of", "the", "six", "IgE-binding", "components", ",", "including", "the", "major", "C3274161#ent", "<e1>", ",", "seem", "to", "be", "C0072522#ent", "<e2>", ",", "as", "confirmed", "by", "the", "lectin", "blotting", "analysis", "."], "h": {"id": "C3274161", "name": "C3274161#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [16, 17]}}
{"token": ["The", "C0238402#ent", "<e1>", "mucopolysaccharidosis", "type", "VI", "MPS", "VI", "is", "a", "lysosomal", "storage", "disease", "by", "deficiency", "of", "the", "C0003940#ent", "<e2>", "ASB", ")", "."], "h": {"id": "C0238402", "name": "C0238402#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003940", "name": "C0003940#ent", "pos": [17, 18]}}
{"token": ["The", "clinical", "course", "to", "6", "years", "of", "age", "is", "described", "in", "a", "boy", "with", "C0238402#ent", "<e1>", "indicated", "by", "the", "clinical", "characteristics", "increased", "urinary", "excretion", "dermatan", "sulphate", "deficiency", "of", "C0003940#ent", "<e2>", "leucocytes", "and", "cultured", "skin", "fibroblasts", "."], "h": {"id": "C0238402", "name": "C0238402#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003940", "name": "C0003940#ent", "pos": [28, 29]}}
{"token": ["The", "in", "vitro", "activity", "of", "newly", "synthesized", "bis-(chlorophenyl)-azabicyclo[3.2.2]nonanes", "and", "bis-(chlorophenyl)-bicyclo[2.2.2]octanes", "against", "C0024535#ent", "<e1>", "resistant", "to", "chloroquine", "and", "C0034283#ent", "<e2>", ")", "and", "Trypanosoma", "brucei", "rhodesiense", "investigated", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [17, 18]}}
{"token": ["Controversy", "exists", "regarding", "the", "safety", "of", "intravenous", "C0012582#ent", "<e1>", "in", "patients", "with", "severe", "chronic", "obstructive", "pulmonary", "disease", "C0024117#ent", "<e2>", ")", ",", "and", "it", "is", "contraindicated", "in", "patients", "with", "asthma", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [17, 18]}}
{"token": ["We", "describe", "the", "occurrence", "of", "sudden", "severe", "and", "respiratory", "arrest", "C0012582#ent", "<e1>", "infusion", "in", "a", "patient", "with", "C0024117#ent", "<e2>", "of", "the", "emphysematous", "type"], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [17, 18]}}
{"token": ["Transcriptional", "fusions", "spoVG-lacZ", "to", "this", "C0029073#ent", "<e1>", "show", "regulation", "of", "C0005220#ent", "<e2>", "expression", "by", "glucose", ",", "indicating", "that", "glucose", "repression", "at", "the", "level", "of", "transcription", "."], "h": {"id": "C0029073", "name": "C0029073#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [10, 11]}}
{"token": ["Our", "study", "presents", "evidence", "that", "C1422492#ent", "<e1>", "is", "a", "potential", "C0079427#ent", "<e2>", "renal", "carcinoma", "that", "CoAM", "is", "a", "counterbalancing", "splice", "isoform"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [10, 11]}}
{"token": ["The", "indications", "for", "operation", "were", "C1442521#ent", "<e1>", "secondary", "to", "chronic", "renal", "failure", "24", "patients", "(", "22", "of", "whom", "had", "C0149911#ent", "<e2>", ")", "and", "persistent", "or", "recurrent", "primary", "C1442521#ent", "<e1>", "in", "2", "cases", "."], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149911", "name": "C0149911#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "identify", "that", "this", "human", "C0027203#ent", "<e1>", "is", "an", "ADT", "sulfotransferase", "well", "as", "a", "C1420519#ent", "<e2>", "implying", "an", "important", "role", "in", "steroid", "homeostasis", "for", "the", "adrenals", "and", "liver", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420519", "name": "C1420519#ent", "pos": [15, 16]}}
{"token": ["We", "determined", "that", "the", "nuclear", "receptor", "CAR", "is", "required", "to", "coordinately", "up-regulate", "hepatic", "expression", "of", "Mrp4", "and", "an", "C0027203#ent", "<e1>", "known", "to", "sulfate", "hydroxy-bile", "acids", "and", "steroids", ",", "C1420519#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420519", "name": "C1420519#ent", "pos": [28, 29]}}
{"token": ["C0004057#ent", "<e1>", "indomethacin", "are", "analgesic", "for", "C0030193#ent", "<e2>", "stimuli", ",", "and", "this", "has", "been", "demonstrated", "when", "the", "noxious", "stimuli", "are", "applied", "to", "normal", "and", "inflamed", "tissue", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [6, 7]}}
{"token": ["Previous", "studies", "demonstrated", "that", "IGF-II", "binds", "directly", "to", "C1336937#ent", "<e1>", "(", "VN", ")", ",", "whereas", "C1334089#ent", "<e2>", "binds", "poorly", "."], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [15, 16]}}
{"token": ["However", ",", "if", "C1336937#ent", "<e1>", "was", "used", "as", "the", "substratum", ",", "C1334089#ent", "<e2>", "stimulated", "migration", "by", "162", "%", "even", "in", "the", "absence", "of", "serum", "."], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [11, 12]}}
{"token": ["In", "order", "to", "assess", "the", "genetic", "basis", "this", "C0039082#ent", "<e1>", "we", "investigated", "two", "candidate", "genes", ":", "ATP2C2", "and", "C1412639#ent", "<e2>", "encoding", "the", "manganese-transporting", "calcium-ATPases", ",", "SPCA2", "and", "SERCA3", ",", "respectively", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412639", "name": "C1412639#ent", "pos": [18, 19]}}
{"token": ["To", "gain", "insights", "into", "how", "C1416373#ent", "<e1>", "mutants", "affect", "basal", "activity", "we", "focused", "on", "C0669365#ent", "<e2>", "activating", "pathogenic", "mutant", "I568V", "in", "C1416373#ent", "<e1>", ",", "which", "exhibits", "elevated", "basal", "activity"], "h": {"id": "C1416373", "name": "C1416373#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}}
{"token": ["C0006035#ent", "<e1>", "a", "tick-borne", "mediated", "C0029877#ent", "<e2>", "by", "a", "newly", "recognized", "spirochete", ",", "Borrelia", "burgdorferi"], "h": {"id": "C0006035", "name": "C0006035#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [5, 6]}}
{"token": ["The", "distribution", "of", "the", "different", "types", "of", "oligosaccharides", "in", "C1332805#ent", "<e1>", "in", "beta-hexosaminidase", "synthesized", "cultured", "human", "fibroblasts", "was", "studied", "by", "using", "C0014159#ent", "<e2>", "a", "probe", "for", "high-mannose", "oligosaccharides"], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014159", "name": "C0014159#ent", "pos": [21, 22]}}
{"token": ["Essentially", "all", "of", "the", "oligosaccharides", "of", "C1332805#ent", "<e1>", "be", "released", "by", "C0014159#ent", "<e2>", "pointing", "to", "oligomannoside", "types", "of", "structures", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014159", "name": "C0014159#ent", "pos": [11, 12]}}
{"token": ["Chondrocytes", "modulated", "by", "serial", "subcultures", "in", "monolayer", "secreted", "more", "cathepsin", "B", "but", "less", "C0962754#ent", "<e1>", "than", "differentiated", "cells", "cultured", "within", "C1333079#ent", "<e2>", "."], "h": {"id": "C0962754", "name": "C0962754#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333079", "name": "C1333079#ent", "pos": [20, 21]}}
{"token": ["The", "C0962754#ent", "<e1>", "activities", "of", "conditioned", "medium", "HMMEC", "culture", "on", "C1333079#ent", "<e2>", "considerably", "higher", "in", "tumor", "conditioned", "medium", "those", "from", "HUVECs", "were", "undetectable", "."], "h": {"id": "C0962754", "name": "C0962754#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333079", "name": "C1333079#ent", "pos": [10, 11]}}
{"token": ["Out", "of", "20", "patients", "with", "C2751824#ent", "<e1>", "DSD", ",", "only", "one", "(", "5", "%", ")", "displayed", "C0268301#ent", "<e2>", "AIS", ")", ",", "and", "four", "(", "20", "%", ")", "were", "5alpha-reductase", "deficient", "by", "mutation", "analysis"], "h": {"id": "C2751824", "name": "C2751824#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268301", "name": "C0268301#ent", "pos": [16, 17]}}
{"token": ["Primary", "amenorrhea", "C2751824#ent", "<e1>", "females", "can", "be", "due", "to", "complete", "C0268301#ent", "<e2>", "CAIS", ")", ",", "pure", "gonadal", "dysgenesis", "17-hydroxysteroid", "dehydrogenase", "deficiency", "or", "mixed", "gonadal", "dysgenesis"], "h": {"id": "C2751824", "name": "C2751824#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268301", "name": "C0268301#ent", "pos": [10, 11]}}
{"token": ["During", "C0004623#ent", "<e1>", "the", "balance", "between", "resolution", "of", "infection", "and", "development", "of", "C0243026#ent", "<e2>", "is", "dependent", "upon", "the", "macrophage", "response", "to", "bacterial", "products"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}}
{"token": ["In", "this", "respect", "C1826698#ent", "<e1>", "differs", "from", "coactivators", "PRMT1", "and", "CARM1", "(", "C0769198#ent", "<e2>", "."], "h": {"id": "C1826698", "name": "C1826698#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0769198", "name": "C0769198#ent", "pos": [12, 13]}}
{"token": ["C0085251#ent", "<e1>", ",", "tocainide", ",", "and", "C0543459#ent", "<e2>", "are", "effective", "in", "treating", "acute", "and", "chronic", "ventricular", "arrhythmias"], "h": {"id": "C0085251", "name": "C0085251#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [6, 7]}}
{"token": ["Using", "a", "case-control", "design", "study", "we", "genotyped", "246", "C0154723#ent", "<e1>", "patients", "and", "239", "healthy", "controls", "the", "1246G-->A", "polymorphism", "of", "the", "C1415502#ent", "<e2>", "HCRTR2", ")", "gene", "."], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415502", "name": "C1415502#ent", "pos": [20, 21]}}
{"token": ["The", "higher", "resolution", "of", "the", "covalent", "complex", "has", "enabled", "the", "location", "of", "ordered", "water", "molecules", "the", "C0010796#ent", "<e1>", "serve", "to", "bridge", "between", "the", "two", "C0086376#ent", "<e2>", "by", "hydrogen", "bonding"], "h": {"id": "C0010796", "name": "C0010796#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [24, 25]}}
{"token": ["The", "activity", "of", "C1706445#ent", "<e1>", "is", "therefore", "context", "dependent", ",", "and", "evidence", "for", "C1706445#ent", "<e1>", "C0812382#ent", "<e1>", "particular", "cells", "is", "insufficient", "to", "indicate", "C1706445#ent", "<e1>", "function", "in", "transcriptional", "activation", "growth", "control"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1706445", "name": "C1706445#ent", "pos": [3, 4]}}
{"token": ["However", ",", "Nef", "does", "not", "affect", "the", "C0812382#ent", "<e1>", "other", "transcription", "factors", "in", "HIV-1", "regulation", ",", "including", "SP-1", ",", "C1706445#ent", "<e2>", ",", "URS", ",", "and", "NF-AT", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706445", "name": "C1706445#ent", "pos": [19, 20]}}
{"token": ["In", "testing", "this", "hypothesis", "individuals", "were", "identified", "in", "whom", "one", "allele", "of", "the", "C0079429#ent", "<e1>", "encoding", "the", "DNA", "mismatch", "repair", "protein", "C0879389#ent", "<e2>", "is", "epigenetically", "silenced", "the", "soma", "(", "implying", "a", "germline", "event", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0879389", "name": "C0879389#ent", "pos": [21, 22]}}
{"token": ["Moreover", "C1419771#ent", "<e1>", "has", "an", "active", "role", "in", "regulating", "C3539665#ent", "<e2>", "levels", "in", "osteoblast", "precursors", "."], "h": {"id": "C1419771", "name": "C1419771#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539665", "name": "C3539665#ent", "pos": [9, 10]}}
{"token": ["C0171406#ent", "<e1>", "the", "main", "O(2)(-", ")", "producer", "of", "the", "C0171406#ent", "<e1>"], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [0, 1]}}
{"token": ["The", "mid-frequency", "(", "MF", ";", "0.2", "-", "0.6", "Hz", ")", "oscillations", "of", "SBP", "and", "diastolic", "BP", "C1415740#ent", "<e1>", ")", "were", "decreased", "by", "prazosin", "alone", "or", "associated", "with", "or", "C0126174#ent", "<e2>", "."], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [28, 29]}}
{"token": ["The", "gastric", "emptying", "study", "Tc-99", "m", "triethylene", "tetramine", "polystyrene", "resin", "with", "or", "without", "C0887128#ent", "<e1>", "used", "in", "six", "patients", "with", "different", "disease", "entities", "C0014848#ent", "<e2>", ",", "gastric", "lymphoma", "primary", "amyloidosis", "Zollinger-Ellison", "syndrome", "duodenal", "diverticulum", "and", "short", "bowel", "syndrome"], "h": {"id": "C0887128", "name": "C0887128#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014848", "name": "C0014848#ent", "pos": [23, 24]}}
{"token": ["Finally", ",", "in", "a", "number", "of", "lipomas", ",", "C3274729#ent", "<e1>", "and", "C1333906#ent", "<e2>", "are", "coexpressed", ",", "and", "C1333906#ent", "<e2>", "augments", "the", "transactivation", "functions", "of", "C3274729#ent", "<e1>", "."], "h": {"id": "C1333906", "name": "C1333906#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274729", "name": "C3274729#ent", "pos": [8, 9]}}
{"token": ["We", "report", "on", "a", "white", "boy", "with", "C0018522#ent", "<e1>", "HSS", ")", "who", "also", "had", "C0948187#ent", "<e2>", "."], "h": {"id": "C0018522", "name": "C0018522#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0948187", "name": "C0948187#ent", "pos": [14, 15]}}
{"token": ["We", "constructed", "vectors", "for", "expression", "in", "E.", "coli", "human", "Jun", "N-terminal", "kinase", "1", "JNK1", ")", ",", "mouse", "Aurora", "kinase", "B", "C1420464#ent", "<e1>", ")", ",", "and", "the", "C0062773#ent", "<e2>", "HAT", ")", "domain", "of", "P/CAF", "."], "h": {"id": "C1420464", "name": "C1420464#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [26, 27]}}
{"token": ["We", "constructed", "vectors", "for", "expression", "in", "E.", "coli", "human", "Jun", "N-terminal", "kinase", "1", "JNK1", ")", ",", "mouse", "C1420464#ent", "<e1>", "Aurkb", ")", ",", "and", "the", "C0062773#ent", "<e2>", "HAT", ")", "domain", "of", "P/CAF", "."], "h": {"id": "C1420464", "name": "C1420464#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [24, 25]}}
{"token": ["Neutrophil", "chemotaxis", "impaired", "by", "chloroquine", "(", "100", "micrograms/ml", ")", "and", "C0282398#ent", "<e1>", "(", "greater", "than", "10", "micrograms/ml", ")", "but", "not", "by", "C0002641#ent", "<e2>", "."], "h": {"id": "C0282398", "name": "C0282398#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002641", "name": "C0002641#ent", "pos": [21, 22]}}
{"token": ["These", "results", "demonstrate", "that", "young", "rats", "fail", "to", "remember", "the", "C1334294#ent", "<e1>", "but", "that", "retention", "for", "this", "C0310298#ent", "<e2>", "can", "be", "specifically", "enhanced", "with", "cholinomimetic", "drugs"], "h": {"id": "C1334294", "name": "C1334294#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [17, 18]}}
{"token": ["By", "contrast", "C0006507#ent", "<e1>", "potentiates", "platelet", "responses", "by", "the", "calcium", "ionophore", "C0022020#ent", "<e2>", "."], "h": {"id": "C0006507", "name": "C0006507#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022020", "name": "C0022020#ent", "pos": [11, 12]}}
{"token": ["C0030956#ent", "<e1>", "generated", "from", "proteolysis", "of", "the", "amyloid", "precursor", "proteins", "C1705770#ent", "<e2>", ")", "by", "beta-", "and", "gamma-secretases."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705770", "name": "C1705770#ent", "pos": [10, 11]}}
{"token": ["Pulse-chase", "experiments", "reveal", "that", "both", "C0030956#ent", "<e1>", "are", "secreted", "in", "parallel", "with", "soluble", "beta", "APP", "C1705770#ent", "<e2>", ")", ";", "no", "precursor-product", "relation", "between", "A", "beta", "and", "p3", "was", "found", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705770", "name": "C1705770#ent", "pos": [15, 16]}}
{"token": ["The", "uptake", "of", "radiolabelled", "2-deoxyglucose", "(", "2DG", ")", "was", "used", "to", "compare", "the", "effects", "of", "steroid", "anaesthetic", "C0002348#ent", "<e1>", "(", "alphaxalone", "plus", "alphadolone", "acetate", "with", "those", "of", "C0030883#ent", "<e2>", "the", "regional", "metabolism", "the", "brain", "and", "pituitary", "gland"], "h": {"id": "C0002348", "name": "C0002348#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [27, 28]}}
{"token": ["CDM", "whose", "mothers", "were", "classified", "with", "regard", "to", "C0011847#ent", "<e1>", "during", "pregnancy", "as", "class", "B", "C", "with", "subsequent", "C0040524#ent", "<e2>", "of", "pregnancy", "(", "n", "=", "27", ")", ",", "3", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040524", "name": "C0040524#ent", "pos": [18, 19]}}
{"token": ["The", "C2975999#ent", "<e1>", "HMGR", ")", "inhibitory", "activity", "of", "7-(aryl/biphenyl)-6-heptenoic", "C0815040#ent", "<e2>", "was", "quantitatively", "analysed", "using", "hydrophobicity", ",", "van", "der", "Waals", "volume", "and", "electronic", "parameters"], "h": {"id": "C2975999", "name": "C2975999#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [9, 10]}}
{"token": ["The", "interaction", "of", "proteins", "with", "hydroxyapatite", "(", "C1419770#ent", "<e1>", ")", ",", "specifically", "proteoglycans", "and", "their", "spatial", "arms", "C3536869#ent", "<e2>", "(", "GAGs", ")", "in", "addition", "to", "serum", "proteins", "play", "an", "important", "role", "in", "regulating", "biological", "mineralisation"], "h": {"id": "C1419770", "name": "C1419770#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536869", "name": "C3536869#ent", "pos": [17, 18]}}
{"token": ["Hypertonic", "saline", "solution", "C1420015#ent", "<e1>", ")", "has", "been", "investigated", "in", "the", "treatment", "of", "C0151740#ent", "<e2>", "ICH", ")", "in", "a", "limited", "number", "of", "studies", ",", "usually", "after", "failure", "of", "conventional", "treatment"], "h": {"id": "C1420015", "name": "C1420015#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "the", "exogenous", "inhibitor", "of", "the", "SR", "Ca(2+)-ATPase", "C1538915#ent", "<e1>", ",", "and", "the", "internal", "inhibitor", "the", "C3811222#ent", "<e2>", "peptide", "C28W", ",", "are", "functionally", "analogous", "."], "h": {"id": "C1538915", "name": "C1538915#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811222", "name": "C3811222#ent", "pos": [17, 18]}}
{"token": ["C1335625#ent", "<e1>", "enhances", "glucocorticoid", "receptor-dependent", "transcription", "more", "efficiently", "than", "Miz1", "or", "C3539609#ent", "<e2>", ",", "and", "all", "PIAS", "proteins", "also", "activate", "estrogen", "receptor-", "progesterone", "receptor-dependent", "transcription", "but", "to", "a", "dissimilar", "degree", "."], "h": {"id": "C1335625", "name": "C1335625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539609", "name": "C3539609#ent", "pos": [11, 12]}}
{"token": ["In", "photobleaching", "experiments", "PR", "in", "the", "presence", "of", "the", "C2987634#ent", "<e1>", "R5020", "exhibits", "rapid", "exchange", "with", "the", "C1710651#ent", "<e2>", "promoter", "in", "living", "cells"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1710651", "name": "C1710651#ent", "pos": [17, 18]}}
{"token": ["Both", "TZD", "and", "insulin", "independently", "stimulated", "PPARgamma-mediated", "transactivation", "of", "C1415350#ent", "<e1>", "promoter-luciferase", "reporter", "genes", ";", "both", "C0991617#ent", "<e2>", "combined", "resulted", "in", "a", "synergistic", "effect"], "h": {"id": "C1415350", "name": "C1415350#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}}
{"token": ["Spur", "cell", "anemia", "a", "C1387532#ent", "<e1>", "in", "patients", "with", "C0023891#ent", "<e2>", "is", "characterized", "by", "unusual", "erythrocyte", "morphology", "and", "an", "increased", "ratio", "of", "free", "cholesterol", "phospholipid", "in", "the", "erythrocyte", "membrane"], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023891", "name": "C0023891#ent", "pos": [9, 10]}}
{"token": ["Severe", "C1387532#ent", "<e1>", "thrombocytopenia", "developed", "in", "a", "56-year-old", "man", "with", "C0023891#ent", "<e2>"], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023891", "name": "C0023891#ent", "pos": [10, 11]}}
{"token": ["Quinine", "and", "its", "d-isomer", "C0034414#ent", "<e1>", "can", "both", "cause", "contact", "allergy", "well", "as", "C0206051#ent", "<e2>", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0206051", "name": "C0206051#ent", "pos": [13, 14]}}
{"token": ["To", "clarify", "the", "prognostic", "factors", "patients", "with", "sustained", "VT", "in", "the", "early", "C0018814#ent", "<e1>", "period", ",", "we", "retrospectively", "surveyed", "961", "consecutive", "patients", "with", "C0155626#ent", "<e2>", "."], "h": {"id": "C0018814", "name": "C0018814#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "show", "that", "the", "previously", "uncharacterized", "Saccharomyces", "cerevisiae", "reading", "frame", "YLR276C", ",", "hereafter", "named", "DBP9", "(", "C0252684#ent", "<e1>", ",", "encodes", "an", "essential", "C1417754#ent", "<e2>", "in", "60S-ribosomal-subunit", "biogenesis", "."], "h": {"id": "C0252684", "name": "C0252684#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417754", "name": "C1417754#ent", "pos": [23, 24]}}
{"token": ["We", "assessed", "DNA", "sequence", "of", "C3541252#ent", "<e1>", "and", "a", "related", "protein", ",", "C1705083#ent", "<e2>", ",", "in", "an", "in", "vitro", "DNA", "binding", "assay"], "h": {"id": "C3541252", "name": "C3541252#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705083", "name": "C1705083#ent", "pos": [12, 13]}}
{"token": ["Tau", "protein", "kinase", "II", "TPKII", ")", "is", "a", "heterodimer", "comprising", "a", "C3640794#ent", "<e1>", "Cdk5", ")", "and", "a", "regulatory", "protein", "neuronal", "Cdk5", "activator", "C1413285#ent", "<e2>", ")", "."], "h": {"id": "C3640794", "name": "C3640794#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413285", "name": "C1413285#ent", "pos": [22, 23]}}
{"token": ["It", "is", "concluded", "that", "C0033626#ent", "<e1>", "associated", "with", "decrease", "in", "the", "disposition", "and", "metabolism", "of", "C0031463#ent", "<e2>", "in", "rats", "."], "h": {"id": "C0033626", "name": "C0033626#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031463", "name": "C0031463#ent", "pos": [15, 16]}}
{"token": ["It", "is", "concluded", "that", "a", "C0033626#ent", "<e1>", "increases", "the", "ulcerogenic", "toxicity", "of", "C0031463#ent", "<e2>", "relative", "to", "its", "useful", "anti-inflammatory", "effects"], "h": {"id": "C0033626", "name": "C0033626#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031463", "name": "C0031463#ent", "pos": [12, 13]}}
{"token": ["Mutations", "in", "the", "VSX1", "(", "C1413420#ent", "<e1>", "gene", "have", "been", "identified", "for", "two", "distinct", ",", "inherited", "C0010036#ent", "<e2>", "posterior", "polymorphous", "corneal", "dystrophy", "keratoconus", "."], "h": {"id": "C1413420", "name": "C1413420#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010036", "name": "C0010036#ent", "pos": [16, 17]}}
{"token": ["This", "relationship", "is", "consistent", "with", "hypothesis", "that", "the", "C0038085#ent", "<e1>", "in", "the", "host", "C0017428#ent", "<e2>", ",", "in", "which", "they", "are", "members", "of", "a", "superfamily", "of", "distantly", "related", "protein", "kinases", "are", "normal", "constituents", "of", "mammalian", "cells"], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [13, 14]}}
{"token": ["Among", "these", "agents", ",", "C0012373#ent", "<e1>", "has", "been", "found", "to", "be", "sufficiently", "potent", "to", "C0020538#ent", "<e2>", "to", "have", "a", "less", "potent", "dilatory", "action", "on", "the", "cerebral", "vasculature", "experimental", "animals"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [14, 15]}}
{"token": ["Prolonged", "medication", "with", "C0012373#ent", "<e1>", "has", "proved", "advantageous", "in", "the", "treatment", "of", "coronary", "insufficiency", "C0020538#ent", "<e2>"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [14, 15]}}
{"token": ["C1418640#ent", "<e1>", "contained", "the", "complete", "C0033209#ent", "<e2>", "a", "part", "of", "proA", "lacking", "the", "proA", "C-terminal", "region"], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [5, 6]}}
{"token": ["Three", "cases", "of", "transitional", "cell", "carcinoma", "C1861305#ent", "<e1>", ")", "metastatic", "to", "the", "C0023899#ent", "<e2>", "are", "reported", "."], "h": {"id": "C1861305", "name": "C1861305#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}}
{"token": ["Twelve", "patients", "with", "end-stage", "liver", "disease", "liver", "transplantation", "studied", "regarding", "complement", "activation", "formation", "of", "anaphylatoxins", "(", "C3a", "and", "C5a", ")", "and", "terminal", "C5b-9", "complement", "complexes", "C1861305#ent", "<e1>", ")", "after", "reperfusion", "of", "the", "grafted", "C0023899#ent", "<e2>", "."], "h": {"id": "C1861305", "name": "C1861305#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [33, 34]}}
{"token": ["There", "are", "numerous", "parallels", "between", "the", "C0001175#ent", "<e1>", "AIDS", ")", "in", "man", "and", "the", "C0021051#ent", "<e2>", "cats", "."], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [14, 15]}}
{"token": ["The", "attention", "currently", "paid", "to", "such", "issues", "related", "to", "TB", "is", "disproportionately", "scant", "by", "comparison", "with", "that", "accorded", "to", "human", "C0001175#ent", "<e1>", "the", "acquired", "C0021051#ent", "<e2>"], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [24, 25]}}
{"token": ["The", "Aspergillus", "nidulans", "C0162832#ent", "<e1>", "expressed", "as", "a", "fusion", "protein", "MalE", "or", "glutathione-S-transferase", "(", "C0796516#ent", "<e2>", ")", "in", "Escherichia", "coli", "and", "used", "for", "the", "purification", "of", "HapC", "and", "the", "preparation", "of", "anti-HapC", "antiserum", "."], "h": {"id": "C0162832", "name": "C0162832#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0796516", "name": "C0796516#ent", "pos": [14, 15]}}
{"token": ["Among", "the", "inherited", "polycystic", "kidney", "diseases", "include", "autosomal", "recessive", "polycystic", "kidney", "disease", "ARPKD", ")", "and", "autosomal", "dominant", "polycystic", "diseases", "as", "von", "Hippel-Lindau", "disease", "tuberous", "sclerosis", "complex", "TSC1", "and", "C1860707#ent", "<e1>", ")", ",", "and", "autosomal", "dominant", "C3149841#ent", "<e2>", "ADPKD", ")", "."], "h": {"id": "C1860707", "name": "C1860707#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [35, 36]}}
{"token": ["Exogenous", "parenteral", "1,25-dihydroxyvitamin", "D3", "steroid-induced", "changes", "in", "serum", "calcium", "and", "phosphorus", ",", "but", "could", "not", "completely", "correct", "the", "low", "intestinal", "C1422342#ent", "<e1>", "nor", "did", "it", "prevent", "the", "development", "of", "C0029453#ent", "<e2>", "."], "h": {"id": "C1422342", "name": "C1422342#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0029453", "name": "C0029453#ent", "pos": [29, 30]}}
{"token": ["A", "rat", "model", "of", "C0019099#ent", "<e1>", "was", "created", "by", "ligating", "the", "left", "anterior", "descending", "coronary", "artery", "induce", "acute", "myocardial", "infarction", "C0155626#ent", "<e2>", ")", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [20, 21]}}
{"token": ["Treatment", "with", "Fos", ",", "Val", ",", "or", "combination", "therapy", "effective", "in", "preventing", "the", "upregulation", "of", "renal", "AQP2", "gene", "protein", "expressions", "C0019099#ent", "<e1>", "rats", "caused", "by", "C0155626#ent", "<e2>", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [25, 26]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "examine", "the", "association", "between", "hospital", "admission", "peripheral", "total", "leukocyte", "count", "and", "the", "neutrophil", "percentage", "the", "subsequent", "development", "of", "C0019099#ent", "<e1>", "in", "patients", "with", "C0155626#ent", "<e2>", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [30, 31]}}
{"token": ["After", "transformation", "of", "this", "recombinant", "plasmid", "into", "BL-21", "(", "DE3", ")", "strain", ",", "Lactose", "and", "C0039512#ent", "<e1>", "were", "used", "to", "induce", "C0017097#ent", "<e2>", "expression", "at", "37", "degrees", "C", "separately", "."], "h": {"id": "C0039512", "name": "C0039512#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017097", "name": "C0017097#ent", "pos": [21, 22]}}
{"token": ["Five", "cases", "of", "Diphyllobothrium", "latum", "infection", "proved", "by", "collection", "of", "C0018889#ent", "<e1>", "after", "treatment", "with", "bithionol", ",", "C0028017#ent", "<e2>", "or", "praziquantel", ",", "during", "1975~1983", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0028017", "name": "C0028017#ent", "pos": [17, 18]}}
{"token": ["C0018889#ent", "<e1>", ",", "recovered", "by", "chemotherapy", "with", "C0028017#ent", "<e2>", ",", "consisted", "of", "32", "strobilae", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0028017", "name": "C0028017#ent", "pos": [7, 8]}}
{"token": ["RNA", "interference", "is", "mediated", "by", "small", "interfering", "RNAs", "produced", "by", "members", "of", "the", "C0073240#ent", "<e1>", "RNase", "III", "family", "represented", "by", "bacterial", "RNase", "III", "eukaryotic", "Rnt1p", ",", "C1709966#ent", "<e2>", "and", "Dicer", "."], "h": {"id": "C0073240", "name": "C0073240#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1709966", "name": "C1709966#ent", "pos": [26, 27]}}
{"token": ["C0073240#ent", "<e1>", "Dicer", "and", "C1709966#ent", "<e2>", ",", "responsible", "for", "miRNA", "processing", ",", "inhibited", "virus", "replication", "in", "peripheral", "blood", "mononuclear", "cells", "HIV-1-infected", "donors", "and", "in", "latently", "infected", "cells", "."], "h": {"id": "C0073240", "name": "C0073240#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1709966", "name": "C1709966#ent", "pos": [4, 5]}}
{"token": ["RNA", "interference", "is", "mediated", "by", "small", "interfering", "RNAs", "produced", "by", "members", "of", "the", "ribonuclease", "III", "C0073240#ent", "<e1>", "family", "represented", "by", "bacterial", "RNase", "III", "eukaryotic", "Rnt1p", ",", "C1709966#ent", "<e2>", "and", "Dicer", "."], "h": {"id": "C0073240", "name": "C0073240#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1709966", "name": "C1709966#ent", "pos": [26, 27]}}
{"token": ["These", "results", "suggest", "that", "the", "charge", "on", "C0006812#ent", "<e1>", "can", "affect", "the", "drug", "'s", "sensitivity", "to", "C1704939#ent", "<e2>", "."], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [16, 17]}}
{"token": ["Previous", "angiographic", "studies", "patients", "with", "stroke", "or", "transient", "ischemic", "attack", "C0007787#ent", "<e1>", ")", "suggest", "that", "extracranial", "atherosclerosis", "more", "common", "in", "whites", "and", "C0752138#ent", "<e2>", "more", "common", "in", "blacks", "."], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0752138", "name": "C0752138#ent", "pos": [22, 23]}}
{"token": ["TMB", "should", "be", "investigated", "and", "treated", "in", "the", "same", "way", "as", "neurologic", "C0007787#ent", "<e1>", "with", "emphasis", "on", "rapid", "detection", "of", "C0752138#ent", "<e2>", "cardiac", "abnormalities", "haematological", "disorders"], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0752138", "name": "C0752138#ent", "pos": [20, 21]}}
{"token": ["The", "therapy", "of", "benign", "malaria", "is", "still", "chloroquine", "plus", "C0033126#ent", "<e1>", ";", "most", "patients", "with", "C0024535#ent", "<e2>", "be", "routinely", "treated", "with", "mefloquine", "."], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [15, 16]}}
{"token": ["C0033126#ent", "<e1>", ",", "an", "8-aminoquinoline", "is", "also", "given", "to", "patients", "with", "C0024535#ent", "<e2>", "malaria", ",", "in", "a", "single", ",", "45-mg", "dose", ",", "to", "kill", "the", "gametocytes", "and", "so", "reduce", "transmission", "."], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "effectiveness", "and", "safety", "of", "the", "combination", "of", "artesunate", ",", "sulphadoxine", "+", "pyrimethamine", "and", "C0033126#ent", "<e1>", "in", "the", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [21, 22]}}
{"token": ["C0033126#ent", "<e1>", "can", "be", "used", "as", "gametocytocide", "and", "sporontocide", "for", "C0024535#ent", "<e2>", "malaria", "in", "Thailand", "if", "the", "drug", "is", "administered", "when", "matured", "gametocytes", "appeared", "in", "the", "peripheral", "blood"], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [10, 11]}}
{"token": ["This", "case", "illustrates", "the", "course", "of", "a", "C0524620#ent", "<e1>", "was", "detected", "at", "an", "early", "stage", "front", "of", "an", "C0000889#ent", "<e2>", "association", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000889", "name": "C0000889#ent", "pos": [18, 19]}}
{"token": ["The", "mechanism", "of", "biosynthetic", ",", "transferase", ",", "C1706373#ent", "<e1>", ",", "and", "transphosphorylation", "reactions", "catalyzed", "by", "unadenylylated", "C0017801#ent", "<e2>", "E.", "coli", "studied", "."], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017801", "name": "C0017801#ent", "pos": [16, 17]}}
{"token": ["A", "spin-labeled", "ATP", "analogue", ",", "2,2,6,6-tetramethylpiperidine-1-oxyl", "C1706373#ent", "<e1>", "Tempo-ATP", ")", "is", "used", "to", "adenylate", "Escherichia", "coli", "C0017801#ent", "<e2>", "L-glutamine", ":", "ammonia", "ligase", "ADP-forming", ")", ",", "EC", "6.3.1.2", "."], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017801", "name": "C0017801#ent", "pos": [16, 17]}}
{"token": ["Cyclic", "C4285220#ent", "<e1>", "production", "in", "clonal", "HN2", "lines", "overexpressing", "C2700049#ent", "<e2>", "was", "significantly", "higher", "than", "in", "nonoverexpressing", "control", "lines", "and", "increased", "with", "increasing", "total", "FMR-1", "mRNA", "on", "Northern", "blots", "C2700049#ent", "<e2>", "signal", "on", "Western", "blots"], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2700049", "name": "C2700049#ent", "pos": [9, 10]}}
{"token": ["A", "divergent", "transcription", "unit", "immediately", "upstream", "of", "the", "C1333216#ent", "<e1>", "is", "coamplified", "with", "C3853636#ent", "<e2>", "in", "some", "but", "not", "all", "methotrexate-resistant", "cell", "lines", "."], "h": {"id": "C1333216", "name": "C1333216#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853636", "name": "C3853636#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "VDR", ",", "CYP27B1", ",", "and", "C4277558#ent", "<e1>", "determines", "the", "efficacy", "of", "the", "C0003379#ent", "<e2>", "1,25-D3", "and", "is", "distinctly", "related", "to", "the", "degree", "of", "differentiation", "of", "cancerous", "lesions", "."], "h": {"id": "C4277558", "name": "C4277558#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003379", "name": "C0003379#ent", "pos": [14, 15]}}
{"token": ["Cardura", "XL", "due", "to", "favourable", "metabolic", "effects", "as", "well", "as", "the", "unique", "GITS", "technology", "seems", "to", "be", "the", "C0013227#ent", "<e1>", "particularly", "suitable", "in", "hypertensive", "patients", "with", "accompanying", "C0242339#ent", "<e2>", ",", "diabetes", "mellitus", "type", "2", "benign", "prostata", "hypertrophy"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0242339", "name": "C0242339#ent", "pos": [27, 28]}}
{"token": ["The", "renin-angiotensin", "system", "C0525678#ent", "<e1>", ")", "plays", "a", "critical", "role", "in", "blood", "pressure", "control", "body", "fluid", "C3536863#ent", "<e2>", "homeostasis", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [16, 17]}}
{"token": ["C3813120#ent", "<e1>", "(", "alphaMs", ")", "are", "large", "C0072522#ent", "<e2>", "that", "have", "been", "identified", "in", "a", "wide", "range", "of", "vertebrate", "and", "invertebrate", "species", "are", "mostly", "thiol", "ester", "proteinase", "inhibitors"], "h": {"id": "C3813120", "name": "C3813120#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "a", "mixture", "of", "PST", "and", "C1539874#ent", "<e1>", "more", "efficiently", "synthesized", "C0037036#ent", "<e2>", "NCAM", "than", "PST", "or", "C1539874#ent", "<e1>", "alone", "."], "h": {"id": "C0037036", "name": "C0037036#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539874", "name": "C1539874#ent", "pos": [7, 8]}}
{"token": ["In", "the", "current", "study", ",", "we", "analyzed", "the", "C0060441#ent", "<e1>", "and", "FAC", "proteins", "normal", "lymphoblasts", "and", "lymphoblasts", "from", "multiple", "C0015625#ent", "<e2>", "complementation", "groups", "."], "h": {"id": "C0060441", "name": "C0060441#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [19, 20]}}
{"token": ["There", "were", "an", "elevated", "erythrocyte", "sedimentation", "rate", ",", "C0154254#ent", "<e1>", "increased", "levels", "of", "acute", "phase", "proteins", "C0002871#ent", "<e2>", "."], "h": {"id": "C0154254", "name": "C0154254#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [16, 17]}}
{"token": ["Children", "with", "cancer", "who", "are", "receiving", "chemotherapy", "seem", "to", "be", "at", "higher", "risk", "of", "C0004610#ent", "<e1>", "and", "meningitis", "due", "to", "C0021400#ent", "<e2>", "Strep", "pneumoniae", "are", "normal", "children", "."], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [20, 21]}}
{"token": ["Nonetheless", ",", "several", "studies", "suggest", "that", "statins", "improve", "outcomes", "in", "patients", "with", "C0004610#ent", "<e1>", "and", "pneumonia", "and", "might", "be", "similarly", "effective", "against", "C0021400#ent", "<e2>", "."], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [22, 23]}}
{"token": ["C0079405#ent", "<e1>", "has", "a", "critical", "role", "in", "long", "term", "C0001175#ent", "<e2>", "inducing", "infection", "in", "non-dividing", "cells", "as", "monocytes", "and", "macrophages", "."], "h": {"id": "C0079405", "name": "C0079405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [9, 10]}}
{"token": ["The", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "protease", "is", "an", "essential", "C0079405#ent", "<e1>", "is", "a", "major", "drug", "target", "the", "fight", "against", "C0001175#ent", "<e2>", "AIDS", ")", "."], "h": {"id": "C0079405", "name": "C0079405#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "C0812313#ent", "<e1>", "is", "activated", "by", "the", "C0752312#ent", "<e2>", "ERK", "for", "the", "AP-1", "subunits", "c-Jun", "and", "C0812313#ent", "<e1>", "to", "mediate", "VEGF", "regulaltion", "of", "hypoglycemia", "."], "h": {"id": "C0812313", "name": "C0812313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [9, 10]}}
{"token": ["BCR", "activation", "results", "in", "the", "induction", "of", "c-Fos", ",", "FosB", ",", "and", "C0812313#ent", "<e1>", ",", "and", "expression", "of", "these", "are", "suppressed", "by", "C0752312#ent", "<e2>", "and", "JNK", "inhibitors", "."], "h": {"id": "C0812313", "name": "C0812313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [22, 23]}}
{"token": ["The", "hemodynamic", "profile", "of", "NAPA", "is", "compared", "to", "and", "contrasted", "with", "other", "C0003195#ent", "<e1>", "many", "of", "which", "exert", "significant", "C0003289#ent", "<e2>", "effects", "on", "left", "ventricular", "function"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [19, 20]}}
{"token": ["C0935989#ent", "<e1>", "was", "first", "approved", "by", "the", "Scottish", "Medicines", "Consortium", "(", "C3888088#ent", "<e2>", ")", "in", "January", "2002", "with", "the", "recommendation", "that", "its", "use", "be", "audited", "."], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [11, 12]}}
{"token": ["C0935989#ent", "<e1>", "increased", "the", "expression", "of", "alpha-smooth", "muscle", "actin", "both", "C3888088#ent", "<e2>", "populations", "and", "that", "of", "smoothelin", "in", "S-SMCs", "."], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [10, 11]}}
{"token": ["Inhibition", "of", "PDGFR", "kinase", "C0935989#ent", "<e1>", "or", "AG1296", "significantly", "inhibits", "C3888088#ent", "<e2>", "proliferation", "and", "migration", "induced", "by", "5-HT", "in", "vitro"], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [10, 11]}}
{"token": ["C0027360#ent", "<e1>", "antagonized", "the", "morphine-induced", "changes", "in", "NA", "turnover", "and", "C0032483#ent", "<e2>", "concentrations", "."], "h": {"id": "C0027360", "name": "C0027360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [10, 11]}}
{"token": ["To", "evaluate", "the", "specific", "needs", "and", "types", "of", "C0042798#ent", "<e1>", "LVDs", ")", "in", "patients", "with", "C0242383#ent", "<e2>", "AMD", ")", "so", "as", "to", "use", "the", "residual", "vision", "effectively", "."], "h": {"id": "C0042798", "name": "C0042798#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [15, 16]}}
{"token": ["Unlike", "many", "C0003289#ent", "<e1>", "fluoxetine", "has", "little", "affinity", "for", "muscarinic", ",", "histaminic", "H1", "serotonergic", "5-HT1", "C0162755#ent", "<e2>", ",", "or", "noradrenergic", "alpha", "1", "alpha", "2", "receptors", "rat", "brain", "membranes", "in", "vitro"], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162755", "name": "C0162755#ent", "pos": [15, 16]}}
{"token": ["This", "study", "compared", "the", "antiarrhythmic", "effects", "ibutilide", "with", "the", "class", "IA", "agent", "C0033216#ent", "<e1>", "in", "humans", "during", "AFL", "and", "C4049859#ent", "<e2>", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", "a", "dynamic", "fluctuation", "in", "the", "electrophysiological", "properties", "observed", "with", "C0033216#ent", "<e1>", "infusion", "during", "C4049859#ent", "<e2>", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [17, 18]}}
{"token": ["An", "overview", "of", "genetic", "associations", "cytokine", "genes", "infectious", "disease", "presented", ",", "together", "with", "discussion", "of", "recent", "studies", "in", "a", "number", "of", "C0009450#ent", "<e1>", "hepatitis", ",", "HIV", ",", "malaria", ",", "and", "C0243026#ent", "<e2>", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [30, 31]}}
{"token": ["It", "also", "has", "been", "used", "successfully", "to", "treat", "other", "C0009450#ent", "<e1>", "including", "bacterial", "upper", "respiratory", "tract", "infections", "ear", "infections", "skin", "and", "soft-tissue", "infections", "C0243026#ent", "<e2>", ",", "acute", "and", "subacute", "bacterial", "endocarditis", "enteric", "fever", "brucellosis", ",", "prostatitis", ",", "and", "gonorrhea", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [23, 24]}}
{"token": ["The", "cells", "were", "maintained", "under", "continuous", "C0026249#ent", "<e1>", "stimulation", "with", "glial", "growth", "factor", "C0917964#ent", "<e2>", ",", "achieving", "immortalization", "after", "12", "to", "15", "weeks", "without", "the", "use", "of", "viral", "infection", "oncogene", "transformation", "chemical", "carcinogens"], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [13, 14]}}
{"token": ["We", "also", "examined", "the", "expression", "of", "C0026249#ent", "<e1>", "activated", "protein", "kinase", "(", "MAPK", ")", "after", "the", "C0917964#ent", "<e2>", "treatment", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [16, 17]}}
{"token": ["The", "possible", "role", "or", "the", "linkage", "of", "C0026454#ent", "<e1>", "a", "number", "of", "C0029896#ent", "<e2>", "can", "now", "be", "investigated", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [12, 13]}}
{"token": ["A", "transient", "rise", "in", "transmitter", "C0026454#ent", "<e1>", "levels", "of", "plasma", "and", "cerebrospinal", "fluid", "in", "these", "C0029896#ent", "<e2>", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [15, 16]}}
{"token": ["For", "the", "C1332416#ent", "<e1>", "dogs", "in", "both", "studies", ",", "C1366535#ent", "<e2>", "immediately", "after", "hypophysectomy", "and", "resolved", "within", "2", "weeks", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [9, 10]}}
{"token": ["After", "9", "years", "median", "follow-up", ",", "up", "to", "60", "%", "of", "the", "C1332416#ent", "<e1>", "patients", "rely", "on", "hormone", "replacement", "40", "%", "present", "C1366535#ent", "<e2>", "and", "18", "%", "are", "obese", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [22, 23]}}
{"token": ["A", "61-year-old", "man", "with", "C0038013#ent", "<e1>", "treated", "with", "etanercept", "(", "soluble", "C1363984#ent", "<e2>", "and", "in", "remission", "from", "the", "C0038013#ent", "<e1>", "with", "dorsal", "tenosynovitis", "his", "right", "wrist"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1363984", "name": "C1363984#ent", "pos": [11, 12]}}
{"token": ["She", "was", "put", "on", "C0033497#ent", "<e1>", ",", "but", "went", "into", "a", "severe", "C0018801#ent", "<e2>"], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}}
{"token": ["Injudicious", "use", "of", "C0033497#ent", "<e1>", "may", "provoke", "C0018801#ent", "<e2>", "asthma", "in", "susceptible", "individuals", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "C0068815#ent", "<e1>", "and", ",", "in", "part", ",", "C2604870#ent", "<e2>", "O-demethylations", "are", "catalyzed", "by", "cytochrome", "P-448", "and", "cytochrome", "P-450", "electrons", "from", "cytochrome", "b5"], "h": {"id": "C0068815", "name": "C0068815#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2604870", "name": "C2604870#ent", "pos": [11, 12]}}
{"token": ["It", "is", "seldom", "considered", "in", "the", "differential", "diagnosis", "C0018203#ent", "<e1>", "to", "its", "rarity", "and", "histological", "similarity", "to", "other", "C0012634#ent", "<e2>", "."], "h": {"id": "C0018203", "name": "C0018203#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["Overproduction", "of", "variant", "C1333216#ent", "<e1>", "scarcely", "influenced", "the", "sensitivity", "to", "this", "C1254351#ent", "<e2>", "."], "h": {"id": "C1333216", "name": "C1333216#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}}
{"token": ["Combined", "treatment", "albendazole", "and", "LDXGT", "gave", "better", "results", "than", "monotherapy", "based", "on", "either", "C1254351#ent", "<e1>", ",", "apparently", "inhibiting", "C0154652#ent", "<e2>", "antagonists", "of", "the", "PA/MMP-9", "system", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0154652", "name": "C0154652#ent", "pos": [18, 19]}}
{"token": ["Paroxysmal", "atrial", "fibrillation", "PAF", ")", "often", "accompany", "C0010054#ent", "<e1>", "CHD", ")", ",", "and", "C0152171#ent", "<e2>", "PH", ")", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0152171", "name": "C0152171#ent", "pos": [13, 14]}}
{"token": ["Aorta", "and", "pulmonary", "arteries", "removed", "from", "patients", "with", "dilated", "cardiomyopathy", "CDM", ")", ",", "C0010054#ent", "<e1>", "IHD", ")", ",", "and", "C0152171#ent", "<e2>", "PPH", ")", "and", "compared", "with", "controls", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0152171", "name": "C0152171#ent", "pos": [19, 20]}}
{"token": ["Reporter", "assays", "using", "a", "C1413580#ent", "<e1>", "promoter", "with", "multimerized", "Col2a1", "Sox9-binding", "sites", "indicated", "that", "C1705504#ent", "<e2>", "enhanced", "the", "transcriptional", "activity", "Sox9", "."], "h": {"id": "C1413580", "name": "C1413580#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705504", "name": "C1705504#ent", "pos": [14, 15]}}
{"token": ["The", "addition", "of", "C0878189#ent", "<e1>", "caused", ":", "a", ")", "blockade", "of", "C0234238#ent", "<e2>", "activity", ",", "and", "b", ")", "C0878189#ent", "<e1>", "concentration-dependent", "decrease", "of", "Fmax", "and/or", "disappearance", "of", "m.e.p.p.s", "from", "neuromuscular", "junctions", "treated", "with", "Li+", "."], "h": {"id": "C0878189", "name": "C0878189#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0234238", "name": "C0234238#ent", "pos": [11, 12]}}
{"token": ["Piroxicam", "was", "most", "expensive", ",", "and", "C0700583#ent", "<e1>", "and", "ketoprofen", "least", "expensive", "C0003211#ent", "<e2>", "within", "DU95", "%", "in", "2001", "and", "2002", ",", "respectively", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [6, 7]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}}
{"token": ["Organic", "cations", "as", "tetraethylammonium", ",", "guanidine", ",", "C0280858#ent", "<e1>", ",", "and", "quinidine", "did", "not", "interact", "with", "C1420143#ent", "<e2>", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420143", "name": "C1420143#ent", "pos": [16, 17]}}
{"token": ["It", "commonly", "leads", "to", "C0024110#ent", "<e1>", "occasionally", "to", "septic", "arthritis", "osteomyelitis", ",", "or", "liver", "or", "C0272412#ent", "<e2>"], "h": {"id": "C0024110", "name": "C0024110#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0272412", "name": "C0272412#ent", "pos": [15, 16]}}
{"token": ["This", "article", "reviews", "the", "results", "of", "double-blind", "comparative", "studies", "the", "therapeutic", "use", "of", "C0022251#ent", "<e1>", "5-mononitrate", "as", "monotherapy", "in", "the", "prophylaxis", "of", "C0002962#ent", "<e2>"], "h": {"id": "C0022251", "name": "C0022251#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [22, 23]}}
{"token": ["Clenbuterol", ",", "a", "C3536829#ent", "<e1>", "is", "used", "in", "the", "treatment", "of", "recurrent", "C0001883#ent", "<e2>", "horses", "."], "h": {"id": "C3536829", "name": "C3536829#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "plasma", "C1333673#ent", "<e1>", "concentrations", "remained", "unmodified", "after", "C0004609#ent", "<e2>", "treatment", "in", "the", "parkinsonian", "patients", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004609", "name": "C0004609#ent", "pos": [10, 11]}}
{"token": ["Visual", "observation", "of", "the", "monkeys", "during", "this", "study", "revealed", "that", "C0022643#ent", "<e1>", "caused", "emesis", "in", "9/9", "animals", ",", "while", "C0625985#ent", "<e2>", "and", "control", "had", "no", "emetic", "effect.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0022643", "name": "C0022643#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0625985", "name": "C0625985#ent", "pos": [19, 20]}}
{"token": ["C0022643#ent", "<e1>", "and", "khelloside", "(", "C0625985#ent", "<e2>", "were", "examined", "in", "female", "cynomolgus", "monkeys", "to", "substantiate", "their", "ability", "to", "favorably", "modify", "serum", "lipoprotein", "cholesterol"], "h": {"id": "C0022643", "name": "C0022643#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0625985", "name": "C0625985#ent", "pos": [5, 6]}}
{"token": ["The", "target", "molecule", "of", "pemphigus", "autoantibodies", "a", "transmembrane", "desmosomal", "component", ",", "C1414170#ent", "<e1>", "Dsg3", ")", "in", "pemphigus", "vulgaris", "PV", ")", "and", "C1414168#ent", "<e2>", "in", "pemphigus", "foliaceus", "PF", ")", "."], "h": {"id": "C1414170", "name": "C1414170#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414168", "name": "C1414168#ent", "pos": [21, 22]}}
{"token": ["PF", "autoantibodies", "directed", "against", "desmoglein", "(", "Dsg", ")", "1", ";", "PV", "autoantibodies", "bind", "C1414170#ent", "<e1>", "or", "both", "C1414170#ent", "<e1>", "and", "C1414168#ent", "<e1>", "."], "h": {"id": "C1414170", "name": "C1414170#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414168", "name": "C1414168#ent", "pos": [20, 21]}}
{"token": ["To", "determine", "risk", "factors", "pedal", "edema", "patients", "with", "C0030567#ent", "<e1>", "PD", ")", "using", "C0772054#ent", "<e2>"], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0772054", "name": "C0772054#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "genetic", "screens", "a", "possible", "association", "of", "type", "2", "diabetes", "familial", "combined", "C0020473#ent", "<e1>", "with", "the", "C1421376#ent", "<e2>"], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [13, 14]}, "relation": "disease_has_associated_gene", "t": {"id": "C1421376", "name": "C1421376#ent", "pos": [17, 18]}}
{"token": ["The", "metabolism", "of", "C0543476#ent", "<e1>", "was", "investigated", "in", "human", "C0023899#ent", "<e2>", "microsomes", "to", "identify", "the", "specific", "forms", "of", "cytochrome", "P450", "."], "h": {"id": "C0543476", "name": "C0543476#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [9, 10]}}
{"token": ["The", "liver-specific", "organic", "cation", "transport", "protein", "OCT1", ";", "SLC22A1", ")", "transports", "several", "C0007209#ent", "<e1>", "the", "antidiabetic", "drug", "metformin", "and", "the", "anticancer", "agents", "oxaliplatin", "and", "C0939537#ent", "<e2>", "."], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0939537", "name": "C0939537#ent", "pos": [24, 25]}}
{"token": ["We", "performed", "an", "open", ",", "nonrandomized", ",", "multicenter", "phase-II", "trial", "evaluate", "the", "efficacy", "and", "toxicity", "of", "1", "year", "of", "treatment", "with", "the", "oral", "C0043832#ent", "<e1>", "38", "mainly", "nonthalassemic", "patients", "with", "C0282193#ent", "<e2>"], "h": {"id": "C0043832", "name": "C0043832#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0282193", "name": "C0282193#ent", "pos": [30, 31]}}
{"token": ["Caco-2", "cells", "on", "membrane", "filters", "used", "as", "a", "model", "to", "study", "the", "effects", "of", "C0083713#ent", "<e1>", ",", "an", "inhibitor", "of", "C1420392#ent", "<e2>", "on", "cholesterol", "absorption", "the", "intestinal", "epithelia"], "h": {"id": "C0083713", "name": "C0083713#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420392", "name": "C1420392#ent", "pos": [20, 21]}}
{"token": ["Rad6", "mediates", "its", "role", "in", "N-end", "rule-dependent", "protein", "degradation", "via", "interaction", "with", "the", "ubiquitin-protein", "ligase", "Ubr1", "and", "in", "C1333237#ent", "<e1>", "interactions", "with", "the", "DNA", "binding", "protein", "C1434353#ent", "<e2>", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1434353", "name": "C1434353#ent", "pos": [26, 27]}}
{"token": ["Rad6", "mediates", "its", "C1333237#ent", "<e1>", "via", "its", "association", "with", "C1434353#ent", "<e2>", ",", "whose", "DNA", "binding", "activity", "target", "the", "Rad6-Rad18", "complex", "damaged", "sites", "in", "DNA", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1434353", "name": "C1434353#ent", "pos": [9, 10]}}
{"token": ["Available", "data", "do", "not", "show", "any", "decrease", "in", "CL", "of", "the", "C0013227#ent", "<e1>", "more", "information", "is", "needed", "on", "the", "metabolite", "C0068987#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0068987", "name": "C0068987#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "cytokine", "production", "coincided", "with", "the", "onset", "of", "general", "and", "C0037090#ent", "<e1>", "influenza", "and", "with", "the", "development", "of", "a", "C0264515#ent", "<e2>"], "h": {"id": "C0037090", "name": "C0037090#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0264515", "name": "C0264515#ent", "pos": [21, 22]}}
{"token": ["Currently", ",", "the", "most", "popular", "test", "for", "C0405580#ent", "<e1>", "the", "conventional", "rapid", "C1704793#ent", "<e2>", "stimulation", "test", "(", "250", "microg", "C1704793#ent", "<e2>", ")", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [12, 13]}}
{"token": ["While", "no", "evidence", "of", "neurologic", "disease", "leukodystrophy", "or", "myeloneuropathy", ")", "was", "present", "in", "these", "hemizygotes", ",", "C0405580#ent", "<e1>", "compensatory", "high", "C1704793#ent", "<e2>", "release", "was", "found", "in", "both", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [16, 17]}, "relation": "disease_has_associated_gene", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [20, 21]}}
{"token": ["Five", "patients", "with", "C0405580#ent", "<e1>", "documented", "by", "a", "lack", "of", "cortisol", "secretion", "response", "to", "exogenous", "C1704793#ent", "<e2>", ",", "underwent", "a", "4-h", "iv", "infusion", "of", "theophylline", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "PGF2alpha", "augmented", "the", "MAPK", "kinase", "kinase", "activity", "C0139905#ent", "<e1>", ",", "whereas", "basal", "activity", "C0216471#ent", "<e2>", "less", "than", "that", "of", "C0139905#ent", "<e1>", "and", "was", "little", "affected", "by", "PGF2alpha", "."], "h": {"id": "C0216471", "name": "C0216471#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [10, 11]}}
{"token": ["However", ",", "15-deoxy-Delta12,14-prostaglandin", "J2", "does", "not", "inhibit", "C0216471#ent", "<e1>", "ERK1/ERK2", "activation/phosphorylation", "induced", "by", "PMA", "and", "mediated", "by", "C0139905#ent", "<e2>", "."], "h": {"id": "C0216471", "name": "C0216471#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [17, 18]}}
{"token": ["A", "reduction", "in", "atrial", "C1417807#ent", "<e1>", "contents", "occurred", "when", "C0342895#ent", "<e2>", "a", "sodium-deficient", "diet", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [9, 10]}}
{"token": ["Rats", "were", "treated", "with", "C3540800#ent", "<e1>", ",", "imipramine", ",", "C0035179#ent", "<e2>", ",", "and", "C3540800#ent", "<e1>", "combined", "with", "imipramine", "or", "C0035179#ent", "<e2>", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [9, 10]}}
{"token": ["Crouzon", "syndrome", "one", "of", "the", "best", "known", "of", "many", "C0015467#ent", "<e1>", "is", "an", "C3899989#ent", "<e2>", "characterized", "by", "craniosynostosis", ",", "prominent", "eyes", ",", "and", "midfacial", "hypoplasia", "to", "abnormal", "development", "and", "premature", "fusion", "the", "skull", "."], "h": {"id": "C0015467", "name": "C0015467#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3899989", "name": "C3899989#ent", "pos": [13, 14]}}
{"token": ["However", ",", "when", "we", "analyzed", "this", "interaction", "by", "immunoprecipitation", "of", "TIFA", ",", "we", "found", "that", "C2675209#ent", "<e1>", "significantly", "increased", "the", "amount", "of", "C1336666#ent", "<e2>", "coprecipitated", "with", "TIFA", "."], "h": {"id": "C2675209", "name": "C2675209#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1336666", "name": "C1336666#ent", "pos": [22, 23]}}
{"token": ["Neurons", "undergoing", "delayed", "neuronal", "death", "by", "C0178540#ent", "<e1>", "(", "HI", ")", "or", "C0085543#ent", "<e2>", "SE", ")", "showed", "a", "massive", "expression", "of", "c-Jun", "in", "their", "nuclei", "24", "h", "after", "the", "insult", "."], "h": {"id": "C0178540", "name": "C0178540#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [12, 13]}}
{"token": ["Glutamate", ",", "the", "major", "excitatory", "neurotransmitter", "of", "the", "brain", ",", "mediates", "neuronal", "injury", "C0178540#ent", "<e1>", ",", "hypoglycemia", ",", "and", "C0085543#ent", "<e2>"], "h": {"id": "C0178540", "name": "C0178540#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [19, 20]}}
{"token": ["Mutation", "of", "specific", "C0812380#ent", "<e1>", "the", "PRL", "promoter", "reduced", "responsiveness", "to", "both", "TRH", "and", "C1370600#ent", "<e2>", "."], "h": {"id": "C0812380", "name": "C0812380#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [14, 15]}}
{"token": ["It", "is", "likely", "that", "an", "C0812380#ent", "<e1>", "as", "a", "downstream", "transcriptional", "effector", "C1370600#ent", "<e2>", "in", "this", "system", "."], "h": {"id": "C0812380", "name": "C0812380#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "the", "chronic", "activation", "alpha(5)-GABA(A", ")", "receptors", "is", "crucial", "for", "the", "normal", "development", "C0020592#ent", "<e1>", "diazepam", ",", "which", "manifests", "itself", "in", "conjunction", "with", "C1414910#ent", "<e2>"], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414910", "name": "C1414910#ent", "pos": [24, 25]}}
{"token": ["P/Q", "Ca2", "+", "channels", "are", "genetically", "abnormal", "in", "most", "cases", "of", "familial", "hemiplegic", "migraine", "C1832884#ent", "<e1>", ")", "and", "may", "be", "involved", "in", "other", "types", "of", "C0149931#ent", "<e2>", "."], "h": {"id": "C1832884", "name": "C1832884#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [25, 26]}}
{"token": ["The", "t(3;21", ")", "chromosomal", "translocation", "in", "blastic", "crisis", "of", "chronic", "myeloid", "leukemia", "secondary", "leukemias", "results", "in", "a", "formation", "of", "a", "C3274665#ent", "<e1>", "which", "suppresses", "wild-type", "C1335654#ent", "<e2>", "function", "."], "h": {"id": "C3274665", "name": "C3274665#ent", "pos": [20, 21]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [25, 26]}}
{"token": ["C0288171#ent", "<e1>", "is", "registered", "in", "Belgium", "fot", "treatment", "of", "essential", "C0020538#ent", "<e2>", "."], "h": {"id": "C0288171", "name": "C0288171#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [10, 11]}}
{"token": ["Since", "cNOS", "and", "C1412515#ent", "<e1>", "use", "L-arginine", "as", "a", "common", "substrate", ",", "we", "hypothesized", "that", "increased", "C1412515#ent", "<e1>", "activity", "is", "involved", "in", "the", "allergen-induced", "NO", "deficiency", "and", "C1706481#ent", "<e1>", "."], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706481", "name": "C1706481#ent", "pos": [27, 28]}}
{"token": ["Vasculitis", "(", "C0042384#ent", "<e1>", ")", "is", "a", "C0004364#ent", "<e2>", "often", "causes", "fatal", "symptoms", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [7, 8]}}
{"token": ["Clinical", "manifestations", "an", "acute", "systemic", "vasculitic", "syndrome", "characterized", "by", "C0042384#ent", "<e1>", "fever", ",", "arthritis", "and", "sometimes", "associated", "with", "pulmonary", "infiltrates", "peripheral", "edema", ",", "C0004364#ent", "<e2>", "including", "chronic", "cutaneous", "vasculitis", "polyneuropathy", ",", "inflammatory", "bowel", "disease", "glomerulonephritis", ",", "and", "classical", "connective", "tissue", "disorders", "most", "notably", "relapsing", "polychondritis"], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [23, 24]}}
{"token": ["C0042384#ent", "<e1>", "be", "associated", "with", "infections", "and", "C0004364#ent", "<e2>"], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [7, 8]}}
{"token": ["Clinical", "and", "electrophysiological", "findings", "are", "described", "in", "three", "patients", "with", "hereditary", "motor", "C0151313#ent", "<e1>", "association", "with", "optic", "atrophy", "C0393807#ent", "<e2>", "."], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0393807", "name": "C0393807#ent", "pos": [18, 19]}}
{"token": ["A", "cost-effectiveness", "analysis", "the", "potential", "economic", "benefit", "of", "an", "autologous", ",", "platelet-rich", "plasma", "C1412228#ent", "<e1>", ")", "gel", "to", "alternative", "therapies", "in", "treating", "nonhealing", "C0206172#ent", "<e2>"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0206172", "name": "C0206172#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "the", "structure", "integrity", "of", "C0971087#ent", "<e1>", "was", "found", "to", "be", "essential", "for", "the", "interaction", "between", "C1422393#ent", "<e2>", "and", "NKA1b2", "by", "yeast", "two", "hybrid", "method", "a", "series", "of", "C0971087#ent", "<e1>", "truncated", "mutants", "."], "h": {"id": "C0971087", "name": "C0971087#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422393", "name": "C1422393#ent", "pos": [17, 18]}}
{"token": ["Being", "etiologically", "complicated", "and", "obscure", ",", "C1412777#ent", "<e1>", "can", "be", "acquired", "or", "idiopathic", "and", "several", "C0678941#ent", "<e2>", "be", "contributable", "."], "h": {"id": "C1412777", "name": "C1412777#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0678941", "name": "C0678941#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "the", "C1417249#ent", "<e1>", "a", "potentially", "physiologic", "role", "in", "regulating", "C0027021#ent", "<e2>", "."], "h": {"id": "C1417249", "name": "C1417249#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [11, 12]}}
{"token": ["The", "essential", "features", "of", "TOS", "were", "peripheral", "eosinophilia", "pulmonary", "oedema", "endothelial", "damage", "the", "acute", "phase", "myalgia", ",", "sensory", "neuropathy", "hepatic", "injury", "skin", "oedema", "sicca", "in", "the", "intermediate", "phase", "and", "C0235025#ent", "<e1>", "muscle", "wasting", "scleroderma", "and", "C0023895#ent", "<e2>", "in", "the", "chronic", "phase"], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [35, 36]}}
{"token": ["These", "results", "show", "that", "the", "proliferative", "response", "of", "hairy", "cells", "C0065194#ent", "<e1>", "is", "not", "linked", "to", "the", "expression", "of", "the", "C3273109#ent", "<e2>"], "h": {"id": "C0065194", "name": "C0065194#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273109", "name": "C3273109#ent", "pos": [20, 21]}}
{"token": ["Some", "of", "these", "groups", "represent", "well-known", "C0022895#ent", "<e1>", ",", "but", "additional", "C1413514#ent", "<e2>", "identified", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413514", "name": "C1413514#ent", "pos": [11, 12]}}
{"token": ["Antinociception", "by", "nonsteroidal", "antiinflammatory", "drugs", "notably", "C0700583#ent", "<e1>", "and", "S(+)-ibuprofen", ",", "has", "traditionally", "been", "attributed", "to", "peripheral", "tissue", "C0033551#ent", "<e2>", "inhibition", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [18, 19]}}
{"token": ["Indomethacin", "(", "5", "x", "10(-6", ")", "M", ")", "or", "C0700583#ent", "<e1>", "(", "10(-6", ")", "M", ")", ",", "both", "inhibitors", "of", "C0033551#ent", "<e2>", ",", "abolished", "only", "the", "slow", "hyperpolarization", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [20, 21]}}
{"token": ["C0063435#ent", "<e1>", "and", "isopimpinellin", "significantly", "blocked", "ethoxyresorufin", "O-deethylase", "EROD", ")", "and", "C0070319#ent", "<e2>", "PROD", ")", "activities", "in", "epidermis", "at", "1", "and", "24", "h", "after", "oral", "dosing", "."], "h": {"id": "C0063435", "name": "C0063435#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0070319", "name": "C0070319#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "we", "show", "that", "C3811108#ent", "<e1>", "accepts", "an", "amino", "acid-related", "anti-cancer", "agent", "C0025241#ent", "<e2>", "."], "h": {"id": "C3811108", "name": "C3811108#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [14, 15]}}
{"token": ["All", "myeloma", "cells", "4", "cases", "expressed", "C3811108#ent", "<e1>", "at", "a", "high", "level", "and", "incorporated", "C0025241#ent", "<e2>", "."], "h": {"id": "C3811108", "name": "C3811108#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [14, 15]}}
{"token": ["Virus", "neutralization", "hemagglutination-inhibition", "assays", "performed", "for", "quantitating", "antibodies", "against", "canine", "C0012754#ent", "<e1>", "and", "canine", "C0276275#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0012754", "name": "C0012754#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0276275", "name": "C0276275#ent", "pos": [14, 15]}}
{"token": ["The", "low", "ratio", "of", "unchanged", "C1254351#ent", "<e1>", "to", "total", "radioactivity", "in", "plasma", "suggested", "that", "C0054938#ent", "<e2>", "underwent", "rapid", "metabolism", "in", "both", "species", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0054938", "name": "C0054938#ent", "pos": [14, 15]}}
{"token": ["Trifluoperazine", ",", "which", "inhibits", "type-2", "protein", "phosphatases", "had", "little", "effect", "on", "any", "peaks", "while", "levamisole", ",", "an", "alkaline", "phosphatase", "inhibitor", ",", "stimulated", "C1419693#ent", "<e1>", ",", "slightly", "inhibited", "P3", "and", "had", "no", "effect", "C1826529#ent", "<e2>", "."], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1826529", "name": "C1826529#ent", "pos": [32, 33]}}
{"token": ["This", "effect", "is", "not", "due", "to", "a", "direct", "regulatory", "interaction", "pyrimidines", "and", "C1419693#ent", "<e1>", ",", "since", "it", "is", "not", "observed", "when", "C1826529#ent", "<e2>", "is", "inactivated", "by", "insertion", "mutations", "or", "partial", "deletion", "."], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1826529", "name": "C1826529#ent", "pos": [21, 22]}}
{"token": ["By", "using", "two", "statistical", "computer", "methods", "assessment", "of", "the", "extent", "of", "similarity", "between", "C1367714#ent", "<e1>", "and", "other", "known", "beta-lactamase", "amino", "acid", "sequences", "suggested", "that", "C1367714#ent", "<e1>", "is", "a", "class", "A", "C0014442#ent", "<e1>", "."], "h": {"id": "C1367714", "name": "C1367714#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [30, 31]}}
{"token": ["The", "production", "of", "the", "C0752243#ent", "<e1>", "PR1", ",", "and", "the", "C1447694#ent", "<e2>", "PR2", ",", "in", "liquid", "cultures", "19", "isolates", "of", "Metarhizium", "spp"], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [10, 11]}}
{"token": ["C0079427#ent", "<e1>", "studied", "in", "C2609268#ent", "<e2>", "cancer", "for", "correlation", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2609268", "name": "C2609268#ent", "pos": [4, 5]}}
{"token": ["The", "developments", "of", "C0023342#ent", "<e1>", "their", "influences", "on", "the", "epidemiological", "aspects", "Hansen's", "disease", "C0023343#ent", "<e2>", ")", "in", "Japan", "are", "investigated", "."], "h": {"id": "C0023342", "name": "C0023342#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [13, 14]}}
{"token": ["The", "developments", "of", "C0023342#ent", "<e1>", "their", "influences", "on", "the", "epidemiological", "aspects", "C0023343#ent", "<e2>", "leprosy", ")", "in", "Japan", "are", "investigated", "."], "h": {"id": "C0023342", "name": "C0023342#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [11, 12]}}
{"token": ["Pretreatment", "with", "the", "C3850110#ent", "<e1>", "disulfiram", "or", "C0282289#ent", "<e2>", "did", "not", "ameliorate", "the", "testicular", "toxicity", "of", "EGME", "."], "h": {"id": "C3850110", "name": "C3850110#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0282289", "name": "C0282289#ent", "pos": [7, 8]}}
{"token": ["Agonist-induced", "inside-out", "signaling", "results", "in", "an", "increased", "affinity", "of", "integrin", "alpha", "IIb", "beta", "3", "C1955352#ent", "<e1>", "for", "soluble", "ligands", "fibrinogen", "[", "Fg", "]", "and", "C1832660#ent", "<e2>", ")", "."], "h": {"id": "C1955352", "name": "C1955352#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1832660", "name": "C1832660#ent", "pos": [24, 25]}}
{"token": ["Therefore", ",", "we", "aimed", "to", "evaluate", "the", "effectiveness", "of", "local", "insulin", "injection", "on", "median", "nerve", "in", "patients", "with", "non-insulin-dependent", "diabetes", "C3273872#ent", "<e1>", ")", "mellitus", "who", "have", "mild-to-moderate", "C0007286#ent", "<e2>", "TS", ")", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [27, 28]}}
{"token": ["This", "study", "evaluated", "the", "effect", "of", "correction", "of", "serum", "cholesterol", "on", "erectile", "function", "C0529793#ent", "<e1>", "treatment", "in", "patients", "with", "erectile", "dysfunction", "have", "only", "C0020445#ent", "<e2>", "as", "a", "risk", "factor", "erectile", "dysfunction"], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [23, 24]}}
{"token": ["The", "results", "showed", "severe", "C0002871#ent", "<e1>", "in", "patients", "with", "HbS/beta", "zero-thalassaemia", "and", "associated", "alpha-thalassaemia", "and/or", "C2939465#ent", "<e2>"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C2939465", "name": "C2939465#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "C0903898#ent", "<e1>", "as", "well", "as", "sulfonylureas", "inhibit", "the", "transport", "activity", "PEPT1", "and", "C1420101#ent", "<e2>", ",", "although", "C0903898#ent", "<e1>", "itself", "is", "not", "transported", "by", "these", "transporters", "."], "h": {"id": "C0903898", "name": "C0903898#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420101", "name": "C1420101#ent", "pos": [15, 16]}}
{"token": ["Even", "at", "the", "stage", "of", "concentric", "LV", "hypertrophy", "normal", "systolic", "function", "the", "activity", "of", "the", "band", "was", "markedly", "diminished", "in", "C2698698#ent", "<e1>", "compared", "with", "C1418715#ent", "<e2>", "."], "h": {"id": "C2698698", "name": "C2698698#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1418715", "name": "C1418715#ent", "pos": [24, 25]}}
{"token": ["We", "then", "analyzed", "the", "location", "of", "the", "affected", "C2917660#ent", "<e1>", "this", "molecule", "using", "a", "structural", "model", "EPO", "based", "on", "C1417245#ent", "<e2>", "(", "MPO", ")", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417245", "name": "C1417245#ent", "pos": [19, 20]}}
{"token": ["Okadaic", "acid", "1", "microM", ")", "relaxed", "the", "artery", "and", "this", "relaxant", "effect", "was", "partially", "inhibited", "by", "G\u00f66976", ",", "a", "conventional", "C1514555#ent", "<e1>", "and", "calphostin", "C", "an", "inhibitor", "of", "conventional", "and", "novel", "C0657318#ent", "<e2>", "."], "h": {"id": "C1514555", "name": "C1514555#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0657318", "name": "C0657318#ent", "pos": [31, 32]}}
{"token": ["To", "identify", "the", "C1504731#ent", "<e1>", "ACVRL1", ")", "mutations", "in", "a", "Chinese", "family", "hereditary", "hemorrhagic", "telangiectasia", "C1366767#ent", "<e2>", ")", "."], "h": {"id": "C1504731", "name": "C1504731#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366767", "name": "C1366767#ent", "pos": [15, 16]}}
{"token": ["We", "show", "that", "infection", "of", "enterocyte-like", "Caco-2/TC7", "cells", "by", "rhesus", "monkey", "rotavirus", "RRV", ")", "impairs", "the", "biosynthesis", "of", "C1447020#ent", "<e1>", "DPP", "IV", ",", "an", "important", "C1334064#ent", "<e2>", "in", "the", "digestion", "of", "dietary", "proline-rich", "proteins"], "h": {"id": "C1447020", "name": "C1447020#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334064", "name": "C1334064#ent", "pos": [25, 26]}}
{"token": ["We", "present", "a", "case", "of", "recurrent", "acute", "rheumatic", "fever", "a", "patient", "who", "was", "initially", "thought", "to", "be", "suffering", "from", "acute", "C0014121#ent", "<e1>", "her", "previously", "C0277565#ent", "<e2>", "rheumatic", "aortic", "valve", "."], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [24, 25]}}
{"token": ["Altogether", ",", "these", "results", "demonstrate", "for", "the", "first", "time", "the", "implication", "of", "C1333663#ent", "<e1>", "in", "differentiation-specific", "variations", "of", "C0537086#ent", "<e2>", "-", "1", "expression", "."], "h": {"id": "C1333663", "name": "C1333663#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [18, 19]}}
{"token": ["This", "increase", "in", "mRNA", "production", "was", "not", "due", "to", "transcriptional", "up-regulation", "by", "C1333663#ent", "<e1>", "previously", "shown", "to", "regulate", "C0537086#ent", "<e2>", "-", "1", "during", "erythroid", "and", "megakaryocytic", "differentiation"], "h": {"id": "C1333663", "name": "C1333663#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [18, 19]}}
{"token": ["These", "different", "characteristics", "of", "[Ca]i", "signals", "elicited", "by", "the", "C0026249#ent", "<e1>", "and", "the", "C1420232#ent", "<e2>", "ionophore", "indicate", "that", "these", "agents", "use", "different", "mechanisms", "to", "activate", "the", "Na+/H(+)-dependent", "Ca2", "+", "transporting", "system"], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420232", "name": "C1420232#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", ",", "the", "effects", "of", "C0026249#ent", "<e1>", "and", "non-mitogenic", "agents", "and", "of", "C1420232#ent", "<e2>", "exchange", "blocking", "agents", "on", "DNA", "synthesis", "reported", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420232", "name": "C1420232#ent", "pos": [15, 16]}}
{"token": ["As", "a", "consequence", "of", "C1424915#ent", "<e1>", "depletion", "the", "levels", "of", "the", "C1419543#ent", "<e2>", ",", "U5", "and", "U6", "snRNAs", "declined", "dramatically", "."], "h": {"id": "C1424915", "name": "C1424915#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419543", "name": "C1419543#ent", "pos": [11, 12]}}
{"token": ["Our", "data", "indicate", "that", "burn", "complicated", "by", "C0036690#ent", "<e1>", "is", "associated", "with", "pronounced", "C0242350#ent", "<e2>", "burn", "alone", "or", "C0036690#ent", "<e1>", "alone", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "the", "C0242350#ent", "<e1>", "in", "the", "myocardium", "in", "early", "C0036690#ent", "<e2>", "is", "probably", "not", "due", "to", "inadequate", "SR", "removal", "of", "Ca2", "+", "during", "diastole", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [12, 13]}}
{"token": ["The", "goal", "of", "these", "experiments", "was", "to", "evaluate", "the", "potential", "of", "the", "fibroblast", "growth", "factor", "family", "members", "FGF-5", "and", "C1414602#ent", "<e1>", "to", "rescue", "photoreceptors", "from", "cell", "death", "C1285162#ent", "<e2>"], "h": {"id": "C1414602", "name": "C1414602#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [27, 28]}}
{"token": ["This", "observational", "study", "conducted", "across", "Europe", "to", "assess", "health", "outcomes", "men", "with", "erectile", "dysfunction", "ED", ")", "who", "took", "C1176316#ent", "<e1>", ",", "sildenafil", "citrate", "sildenafil", ")", ",", "or", "vardenafil", "HCl", "C0971579#ent", "<e2>", ")", "for", "6", "mo", "."], "h": {"id": "C1176316", "name": "C1176316#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0971579", "name": "C0971579#ent", "pos": [29, 30]}}
{"token": ["The", "COOH", "terminus", "of", "C1424713#ent", "<e1>", "still", "capable", "or", "substantial", "enrichment", "of", "C1417852#ent", "<e2>", "from", "solubilized", "brain", "membranes", "though", "only", "11", "of", "33", "residues", "are", "identical", "with", "the", "COOH", "terminus", "of", "synaptotagmin", "1"], "h": {"id": "C1424713", "name": "C1424713#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417852", "name": "C1417852#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "C4055175#ent", "<e1>", "and", "EGCG", "produce", "opposing", "effects", "on", "C1416524#ent", "<e2>", "expression", "via", "regulation", "of", "C/EBP", "factor", "function", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416524", "name": "C1416524#ent", "pos": [11, 12]}}
{"token": ["C0796176#ent", "<e1>", "SJS", ")", "is", "a", "C0242287#ent", "<e2>", "chondrodysplasia", "."], "h": {"id": "C0796176", "name": "C0796176#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242287", "name": "C0242287#ent", "pos": [6, 7]}}
{"token": ["A", "significant", "similarity", "was", "found", "between", "the", "amino", "acid", "sequences", "from", "the", "nucleotide", "sequence", "BglII", "fragment", "with", "that", "of", "algA", ",", "encoding", "the", "bifunctional", "C0027203#ent", "<e1>", "with", "both", "the", "activities", "of", "C1417244#ent", "<e2>", "guanosine", "diphospho-D-mannose", "pyrophosphorylase", "Pseudomonas", "aeruginosa"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1417244", "name": "C1417244#ent", "pos": [31, 32]}}
{"token": ["Here", "we", "show", "that", "heparin", "no", "longer", "protects", "cathepsin", "G", "inhibition", "when", "the", "C0027203#ent", "<e1>", "is", "reacted", "with", "mucus", "proteinase", "inhibitor", "C1417244#ent", "<e2>", ")", ",", "a", "heparin-binding", "protein"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417244", "name": "C1417244#ent", "pos": [21, 22]}}
{"token": ["In", "the", "nanomolar", "C0027203#ent", "<e1>", "and", "inhibitor", "concentration", "range", ",", "1", "mol", "of", "mucus", "proteinase", "inhibitor", "C1417244#ent", "<e2>", ")", "inhibits", "1", "mol", "of", "neutrophil", "elastase", "cathepsin", "G", "trypsin", ",", "and", "chymotrypsin", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417244", "name": "C1417244#ent", "pos": [16, 17]}}
{"token": ["Previous", "studies", "have", "demonstrated", "that", "NT2N", "neurons", "derived", "from", "a", "human", "embryonal", "carcinoma", "cell", "line", "C0812290#ent", "<e1>", ")", "constitutively", "process", "the", "endogenous", "wild-type", "beta-amyloid", "precursor", "protein", "C1364818#ent", "<e2>", ")", "to", "amyloid", "beta", "peptide", "an", "intracellular", "compartment", "."], "h": {"id": "C0812290", "name": "C0812290#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [26, 27]}}
{"token": ["C1826843#ent", "<e1>", "was", "effective", "in", "improving", "local", "control", "patients", "with", "T2", "to", "C0012634#ent", "<e2>", "LN", "control", "in", "patients", "with", "N0", ",", "N1a", ",", "and", "N1b", "categories"], "h": {"id": "C1826843", "name": "C1826843#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}}
{"token": ["With", "respect", "to", "bone", "cell", "differentiation", "C0600438#ent", "<e1>", "genistein", "each", "significantly", "increased", "basal", "ALP", "specific", "activity", "and", "C0009325#ent", "<e2>", "synthesis", "in", "human", "bone", "cells"], "h": {"id": "C0600438", "name": "C0600438#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [17, 18]}}
{"token": ["Inhibition", "of", "the", "EGFR", "kinase", "(", "C0600438#ent", "<e1>", "AG1478", ")", "prevented", "the", "increase", "of", "C0009325#ent", "<e2>", "."], "h": {"id": "C0600438", "name": "C0600438#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}}
{"token": ["Diabetes", "mellitus", "been", "recognized", "as", "a", "strong", "predictor", "of", "heart", "failure", "C1538440#ent", "<e1>", ")", "in", "patients", "with", "acute", "myocardial", "infarction", "C0155626#ent", "<e2>", ")", "."], "h": {"id": "C1538440", "name": "C1538440#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [20, 21]}}
{"token": ["The", "common", "causes", "of", "ARF", "in", "children", "include", "acute", "tubular", "necrosis", "to", "various", "causes", "(", "including", "congestive", "heart", "failure", "C0243026#ent", "<e1>", ")", ",", "haemolytic", "uremic", "syndrome", "and", "glomerulonephritis", "and", "C0178879#ent", "<e2>"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0178879", "name": "C0178879#ent", "pos": [29, 30]}}
{"token": ["Antioxidant", "and", "anti-inflammatory", "activities", "C1415619#ent", "<e1>", ",", "the", "inducible", "isoform", "of", "C0538674#ent", "<e2>", "have", "been", "demonstrated", "in", "a", "variety", "of", "disease", "models", "a", "therapeutic", "exploitation", "of", "this", "pathway", "is", "currently", "under", "scrutiny", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0538674", "name": "C0538674#ent", "pos": [11, 12]}}
{"token": ["Loss", "of", "CREB/ATF1", "prevented", "the", "expression", "of", "C1335238#ent", "<e1>", ",", "C/EBP", "alpha", "and", "adiponectin", "and", "inhibited", "the", "loss", "of", "C3274855#ent", "<e2>", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3274855", "name": "C3274855#ent", "pos": [19, 20]}}
{"token": ["Peroxisome", "proliferator-activated", "receptor", "gamma", "C1335238#ent", "<e1>", ")", "is", "a", "positive", "regulator", "of", "adipogenesis", ",", "whereas", "C3274855#ent", "<e2>", "Pref-1", ")", "inhibits", "adipocyte", "differentiation", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3274855", "name": "C3274855#ent", "pos": [15, 16]}}
{"token": ["The", "optimal", "regimen", "(", "BACT", "[", "C0935694#ent", "<e1>", ",", "cytarabine", ",", "cyclophosphamide", ",", "C0039902#ent", "<e2>", "]", ")", "and", "setting", "are", "still", "under", "investigation", "for", "the", "various", "grades", "of", "lymphomas", "."], "h": {"id": "C0935694", "name": "C0935694#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [13, 14]}}
{"token": ["In", "the", "literature", ",", "9", "-", "28", "%", "of", "patients", "with", "C1956346#ent", "<e1>", "have", "additional", "C0007282#ent", "<e2>", "predictors", "of", "which", "are", "advanced", "age", "smoking", ",", "diabetes", "mellitus", "arterial", "hypertension", "coronary", "multivessel", "disease", "and", "peripheral", "arterial", "disease"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007282", "name": "C0007282#ent", "pos": [15, 16]}}
{"token": ["Some", "patients", "with", "C0026847#ent", "<e1>", "other", "forms", "of", "C0026850#ent", "<e2>", "also", "examined", "in", "the", "same", "manner", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0026850", "name": "C0026850#ent", "pos": [8, 9]}}
{"token": ["C0085623#ent", "<e1>", ",", "a", "common", "side", "effect", "C0040615#ent", "<e2>", "often", "goes", "unrecognized", "by", "physician", "and", "patient", "."], "h": {"id": "C0085623", "name": "C0085623#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [7, 8]}}
{"token": ["Raptor", "appears", "to", "serve", "as", "an", "mTOR", "scaffold", "protein", "the", "binding", "of", "which", "to", "the", "C0039984#ent", "<e1>", "motif", "of", "C1307407#ent", "<e2>", "substrates", "is", "necessary", "for", "effective", "mTOR-catalyzed", "phosphorylation", "."], "h": {"id": "C0039984", "name": "C0039984#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1307407", "name": "C1307407#ent", "pos": [19, 20]}}
{"token": ["The", "EI+", "mass", "spectrum", "the", "metabolites", "indicated", "the", "formation", "of", "omega-3", "hydroxy-", "omega-2", "hydroxy-", ",", "omega-1", "hydroxy-", "omega-1", "keto-Xanomeline", "in", "addition", "to", "C0051169#ent", "<e1>", "hydroxy-N-desmethyl-Xanomeline", "and", "an", "C0063465#ent", "<e2>", "of", "Xanomeline", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0063465", "name": "C0063465#ent", "pos": [27, 28]}}
{"token": ["The", "presence", "of", "C0599874#ent", "<e1>", "lowers", "the", "yield", "of", "ACC", "conversion", "into", "C0015075#ent", "<e2>", "by", "the", "copper(II)", "complexes", "."], "h": {"id": "C0599874", "name": "C0599874#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015075", "name": "C0015075#ent", "pos": [12, 13]}}
{"token": ["In", "the", "main", "reaction", ",", "2-oxoglutarate", "was", "C0599874#ent", "<e1>", "to", "produce", "one", "molecule", "of", "C0015075#ent", "<e2>", "and", "three", "molecules", "of", "carbon", "dioxide"], "h": {"id": "C0599874", "name": "C0599874#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015075", "name": "C0015075#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "suggest", "that", "C1419067#ent", "<e1>", "provides", "a", "target", "for", "the", "treatment", "of", "C1290884#ent", "<e2>", "pain", "associated", "with", "inflammatory", "states"], "h": {"id": "C1419067", "name": "C1419067#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [13, 14]}}
{"token": ["C0133660#ent", "<e1>", "also", "decreases", "the", "rate", "of", "C0034340#ent", "<e2>", "the", "same", "conditions", ",", "this", "effect", "being", "correlated", "with", "the", "decrease", "of", "intramitochondrial", "content", "of", "ATP", "and", "increase", "of", "AMP", "."], "h": {"id": "C0133660", "name": "C0133660#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034340", "name": "C0034340#ent", "pos": [7, 8]}}
{"token": ["Hyperthyroidism", "may", "present", "various", "C0027868#ent", "<e1>", "namely", "thyrotoxic", "chronic", "myopathy", ",", "myasthenia", "gravis", "disthyroid", "ophthalmopathy", "thyrotoxic", "C1279412#ent", "<e2>"], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1279412", "name": "C1279412#ent", "pos": [16, 17]}}
{"token": ["This", "novel", "role", "of", "C0164786#ent", "<e1>", "in", "regulating", "the", "cellular", "lifespan", "may", "contribute", "to", "various", "C0012634#ent", "<e2>", "atherosclerosis", "and", "diabetes", "mellitus"], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "a", "C0919534#ent", "<e1>", "isoenzyme", "has", "been", "positively", "associated", "with", "protective", "effect", "C0013227#ent", "<e2>", "such", "as", "alkylating", "agents", "anthracyclines", "."], "h": {"id": "C0919534", "name": "C0919534#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [13, 14]}}
{"token": ["The", "Mannose", "Binding", "Lectin", "C2346907#ent", "<e1>", ")", "plays", "an", "important", "role", "in", "innate", "immunity", "its", "C0175683#ent", "<e2>", "associated", "with", "frequent", "and", "prolonged", "infections", "."], "h": {"id": "C2346907", "name": "C2346907#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0175683", "name": "C0175683#ent", "pos": [15, 16]}}
{"token": ["We", "have", "hypothesized", "that", "the", "nonsteroidal", "anti-inflammatory", "drug", "C0083381#ent", "<e1>", ",", "a", "more", "selective", "C1257954#ent", "<e2>", "successfully", "inhibit", "labor", "but", "avoid", "the", "complications", "associated", "with", "inhibition", "of", "cyclooxygenase-1", "."], "h": {"id": "C0083381", "name": "C0083381#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [14, 15]}}
{"token": ["C0083381#ent", "<e1>", ",", "a", "selective", "C1257954#ent", "<e2>", "was", "administered", "orally", "or", "intravaginally", ",", "to", "sperm-positive", "female", "rabbits", "to", "assess", "its", "effect", "on", "ovulation", "."], "h": {"id": "C0083381", "name": "C0083381#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [5, 6]}}
{"token": ["Selective", "C1257954#ent", "<e1>", "C0083381#ent", "<e2>", ",", "nimesulid", ",", "etodolac", "or", "highly", "selective", "C1257954#ent", "<e1>", "celecoxib", ",", "rofecoxib", "have", "antiinflammatory", "and", "analgesic", "properties", "with", "less", "or", "no", "gastrointestinal", "or", "other", "NSAIDs-typical", "adverse", "effects", "."], "h": {"id": "C0083381", "name": "C0083381#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [1, 2]}}
{"token": ["Furthermore", ",", "C0076080#ent", "<e1>", "decreased", "dose-dependently", "the", "MDA", "production", "induced", "by", "exogenous", "C0031667#ent", "<e2>"], "h": {"id": "C0076080", "name": "C0076080#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [12, 13]}}
{"token": ["C0700541#ent", "<e1>", ",", "etomidate", ",", "propofol", ",", "and", "C0700349#ent", "<e2>", "were", "compared", "for", "effects", "on", "and", "interactions", "with", "the", "type", "1", "facilitative", "glucose", "transporter", "GLUT-1", ")", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0700349", "name": "C0700349#ent", "pos": [8, 9]}}
{"token": ["C1417679#ent", "<e1>", "for", "an", "incomplete", "C1335408#ent", "<e2>", "PTS", ")", "have", "been", "found", "in", "the", "genome", "of", "S.", "meliloti", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335408", "name": "C1335408#ent", "pos": [5, 6]}}
{"token": ["These", "C1417679#ent", "<e1>", "include", "a", "C1335408#ent", "<e2>", "mphBM", ")", "and", "a", "cadmium", "efflux", "determinant", "(", "cadA", ")", ",", "together", "with", "the", "gene", "cadC", "coding", "for", "its", "transcriptional", "regulator"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335408", "name": "C1335408#ent", "pos": [5, 6]}}
{"token": ["C1415619#ent", "<e1>", "immunostaining", "showed", "an", "appreciable", "C1415619#ent", "<e1>", "expression", "in", "C1418724#ent", "<e1>", "groups", ",", "which", "was", "abolished", "with", "C1415619#ent", "<e1>", "siRNA", "administration", ",", "but", "not", "in", "ZnPPIX", "group", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418724", "name": "C1418724#ent", "pos": [10, 11]}}
{"token": ["Two", "health", "problems", "reported", "by", "all", "women", ":", "mental", "tension", "to", "C0018681#ent", "<e1>", "and", "white", "vaginal", "discharge", "to", "C0741585#ent", "<e2>", "fatigue", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0741585", "name": "C0741585#ent", "pos": [18, 19]}}
{"token": ["The", "decrease", "in", "free", "thiol", "groups", "during", "incubation", "of", "C1260386#ent", "<e1>", "with", "various", "CNUs", "can", "be", "followed", "using", "the", "thiol", "reagent", "5,5'-dithiobis(2-nitrobenzoic", "acid)", "C1414177#ent", "<e2>", ")", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414177", "name": "C1414177#ent", "pos": [23, 24]}}
{"token": ["Large-scale", "database", "studies", "indicate", "that", "risk", "of", "serious", "GI", "complications", "is", "lower", "with", "C0068334#ent", "<e1>", "than", "comparator", "C0003211#ent", "<e2>", "."], "h": {"id": "C0068334", "name": "C0068334#ent", "pos": [13, 14]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [17, 18]}}
{"token": ["Studies", "in", "patients", "with", "C0013604#ent", "<e1>", "due", "to", "congestive", "heart", "failure", "pulmonary", "oedema", "hepatic", "disease", "that", "oral", "or", "C0006376#ent", "<e2>", "to", "2", "mg/day", "produces", "results", "comparable", "to", "those", "with", "frusemide", "20", "to", "80", "mg/day", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0006376", "name": "C0006376#ent", "pos": [18, 19]}}
{"token": ["C0042373#ent", "<e1>", "the", "brain", "(", "functional", "transient", "and", "ischemic", "apoplexy", ",", "C0085584#ent", "<e2>", "in", "79", "patients", "were", "treated", "by", "electromagnetic", "field", "millimetric", "wave", "range", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [11, 12]}}
{"token": ["The", "distribution", "pattern", "of", "C0694872#ent", "<e1>", "was", "altered", "by", "the", "addition", "of", "C0054549#ent", "<e2>", "a", "scattered", "pattern", "throughout", "the", "embryos", "to", "a", "localized", "pattern", "at", "the", "cell-cell", "boundary", "region", "."], "h": {"id": "C0694872", "name": "C0694872#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054549", "name": "C0054549#ent", "pos": [12, 13]}}
{"token": ["Methionine", "was", "decreased", "and", "C0056886#ent", "<e1>", "was", "increased", "in", "patients", "with", "C0022661#ent", "<e2>"], "h": {"id": "C0056886", "name": "C0056886#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [11, 12]}}
{"token": ["Mutants", "FeS1", "(", "C448S", ")", "and", "C1539266#ent", "<e1>", "(", "C451S", ")", "failed", "to", "form", "active", "C0014442#ent", "<e2>", ",", "assemble", "FeS", "clusters", ",", "or", "undergo", "NH2-terminal", "processing", "."], "h": {"id": "C1539266", "name": "C1539266#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["Colony", "survival", "assays", "further", "establish", "that", "knockdown", "of", "C1415761#ent", "<e1>", "lowers", "resistance", "of", "glioma", "cells", "C0076080#ent", "<e2>", ",", "and", ",", "conversely", ",", "overexpression", "of", "C1415761#ent", "<e1>", "confers", "higher", "resistance", "."], "h": {"id": "C0076080", "name": "C0076080#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415761", "name": "C1415761#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "C0082966#ent", "<e1>", "facilitates", "electrical", "conversion", "of", "C0004238#ent", "<e2>", "by", "lowering", "energy", "requirement", "."], "h": {"id": "C0082966", "name": "C0082966#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [8, 9]}}
{"token": ["In", "the", "current", "study", ",", "the", "frequency", "content", "of", "the", "fibrillatory", "baseline", "on", "the", "ECG", "was", "used", "to", "quantify", "the", "effects", "of", "C0082966#ent", "<e1>", "infusion", "on", "C0004238#ent", "<e2>", "."], "h": {"id": "C0082966", "name": "C0082966#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [26, 27]}}
{"token": ["Following", "CLU-forced", "overexpression", "by", "means", "of", "an", "C0282641#ent", "<e1>", "we", "found", "that", "although", "extracellular", "C1413514#ent", "<e2>", "inhibits", "cell", "death", "all", "three", "OS", "cell", "lines", "intracellular", "C1413514#ent", "<e2>", "has", "different", "effects", "on", "cellular", "proliferation", "survival", "in", "these", "cell", "lines"], "h": {"id": "C0282641", "name": "C0282641#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413514", "name": "C1413514#ent", "pos": [14, 15]}}
{"token": ["A", "notable", "result", "of", "redirecting", "the", "C0524928#ent", "<e1>", "flux", "was", "the", "wall-bound", "accretion", "of", "C3541860#ent", "<e2>", "and", "vanillic", "acid", "probably", "due", "to", "the", "shunt", "pathway"], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541860", "name": "C3541860#ent", "pos": [14, 15]}}
{"token": ["Four", "other", "reported", "C0039082#ent", "<e1>", "cases", "were", "extensively", "screened", "and", "do", "not", "have", "detectable", "C1420322#ent", "<e2>", "mutations", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420322", "name": "C1420322#ent", "pos": [14, 15]}}
{"token": ["C0162557#ent", "<e1>", "FHF", ")", "due", "to", "C0019348#ent", "<e2>", "infection", "is", "a", "clinical", "condition", "known", "in", "pediatric", ",", "immunocompromised", ",", "and", "pregnant", "patients", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [6, 7]}}
{"token": ["A", "description", "follows", "of", "various", "degenerations", "due", "to", "a", "local", "nutritional", "disorder", "with", "C1510471#ent", "<e1>", "onchocercal", "limbitis", "and", "C0701807#ent", "<e2>"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0701807", "name": "C0701807#ent", "pos": [18, 19]}}
{"token": ["A", "clinical", "trial", "conducted", "with", "C0016377#ent", "<e1>", "100", "mg", "three", "times", "a", "day", "by", "mouth", "in", "C0003873#ent", "<e2>", "determine", "variability", "in", "response", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["This", "study", "suggests", "that", "C0016377#ent", "<e1>", "effectively", "controls", "the", "pain", "and", "other", "symptoms", "of", "C0003873#ent", "<e2>", "and", "is", "superior", "in", "safety", "to", "aspirin", "in", "the", "treatment", "of", "patients", "with", "acute", "and", "chronic", "disease"], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["In", "the", "presence", "of", "severe", "hyperbilirubinemia", "in", "C0010324#ent", "<e1>", "a", "fetus", "is", "at", "risk", "for", "C0022610#ent", "<e2>", "."], "h": {"id": "C0010324", "name": "C0010324#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0022610", "name": "C0022610#ent", "pos": [15, 16]}}
{"token": ["The", "elevated", "adenylate", "cyclase", "activity", "observed", "during", "the", "C1696708#ent", "<e1>", "contribute", "to", "the", "C1414672#ent", "<e2>", "of", "hypertension", "."], "h": {"id": "C1696708", "name": "C1696708#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [13, 14]}}
{"token": ["Previous", "studies", "have", "shown", "that", "C0012522#ent", "<e1>", "and", "desloratadine", "effectively", "relieve", "symptoms", "of", "C0035457#ent", "<e2>", "SAR", ")", "."], "h": {"id": "C0012522", "name": "C0012522#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [13, 14]}}
{"token": ["C0686347#ent", "<e1>", "TD", ")", "is", "a", "severe", "side", "effect", "traditional", "C0040615#ent", "<e2>", "affecting", "a", "considerable", "number", "of", "schizophrenic", "patients", "."], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [10, 11]}}
{"token": ["The", "potential", "for", "unwanted", "side", "effects", "particularly", "C0686347#ent", "<e1>", "following", "long-term", "after", "care", "maintenance", "with", "C0040615#ent", "<e2>", "led", "to", "serious", "questioning", "of", "its", "continued", "use", "for", "schizophrenic", "patients", "."], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [15, 16]}}
{"token": ["All", "patients", "exhibited", "C0686347#ent", "<e1>", "other", "extrapyramidal", "side", "effects", "associated", "with", "least", "two", "prior", "C0040615#ent", "<e2>", "."], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "the", "dual", "modification", "of", "N-terminal", "palmitoylation", "C-terminal", "PEGylation", "results", "in", "a", "full", "C2987634#ent", "<e1>", "of", "comparable", "potency", "to", "native", "C1422563#ent", "<e2>", "that", "is", "stable", "to", "DPPIV", "cleavage", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1422563", "name": "C1422563#ent", "pos": [21, 22]}}
{"token": ["Recently", ",", "we", "demonstrated", "that", "high", "glucose", "levels", "mimic", "the", "effects", "of", "phorbol", "esters", "C0033634#ent", "<e1>", "PKC", ")", "and", "C1334133#ent", "<e2>", "J", "Biol", "Chem", "269:3381", "-", "3386", ",", "1994", ")", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [19, 20]}}
{"token": ["C0033634#ent", "<e1>", "also", "contribute", "to", "insulin", "resistance", "phosphorylating", "the", "C1334133#ent", "<e2>", "substrates", "required", "for", "insulin", "signaling"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [9, 10]}}
{"token": ["Our", "findings", "do", "not", "support", "activation", "of", "C0033634#ent", "<e1>", "as", "a", "major", "mechanism", "for", "regulating", "glucose", "uptake", "C1334133#ent", "<e2>", "in", "skeletal", "muscle"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [17, 18]}}
{"token": ["Further", ",", "using", "MEK1", "inhibitor", "C0298346#ent", "<e1>", "we", "showed", "that", "leptin", "activates", "C1705504#ent", "<e2>", "through", "ERK", "induction", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705504", "name": "C1705504#ent", "pos": [12, 13]}}
{"token": ["The", "selective", "mitogen-activated", "protein", "kinase", "MAPK", ")", "inhibitor", "C0298346#ent", "<e1>", "abolished", "high-Ca2+o)-induced", "ERK1/2", "activation", "and", "reduced", "C1705504#ent", "<e2>", "phosphorylation", "in", "both", "cell", "types", "documenting", "MAPK", "'s", "role", "in", "C1705504#ent", "<e2>", "activation", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705504", "name": "C1705504#ent", "pos": [16, 17]}}
{"token": ["This", "interaction", "resulted", "in", "increased", "C0011519#ent", "<e1>", "accessibility", "on", "hyperacetylated", "mononucleosomes", "and", "substantial", "reduction", "of", "C3887564#ent", "<e2>", "to", "cyclobutane", "pyrimidine", "dimers", "UV-irradiated", "mononucleosomes", "but", "not", "on", "naked", "DNA", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3887564", "name": "C3887564#ent", "pos": [15, 16]}}
{"token": ["C1825534#ent", "<e1>", "was", "dissociated", "from", "F-actin", "by", "the", "binding", "of", "C1420872#ent", "<e2>", "to", "F-actin", "."], "h": {"id": "C1825534", "name": "C1825534#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420872", "name": "C1420872#ent", "pos": [10, 11]}}
{"token": ["Review", "of", "our", "experience", "with", "C1541923#ent", "<e1>", "a", "single", "community", "hospital", "coagulase-negative", "staphylococci", "be", "our", "leading", "cause", "of", "C0014118#ent", "<e2>", "."], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [18, 19]}}
{"token": ["We", "compared", "clinical", "features", ",", "response", "to", "therapy", "and", "outcome", "of", "C1541923#ent", "<e1>", "ten", "patients", "with", "mitral", "valve", "prolapse", "23", "patients", "with", "C0014118#ent", "<e2>", "involving", "other", "types", "of", "left-sided", "valvular", "lesions"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [22, 23]}}
{"token": ["We", "isolated", "the", "full-length", "cDNA", "and", "showed", "that", "it", "included", "both", "a", "MADS", "box", "a", "K", "box", ",", "and", "the", "corresponding", "C0079429#ent", "<e1>", "was", "designated", "C1705622#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705622", "name": "C1705622#ent", "pos": [25, 26]}}
{"token": ["C0010977#ent", "<e1>", "may", "be", "a", "potentially", "useful", "drug", "for", "neuroprotection", "after", "C0007785#ent", "<e2>"], "h": {"id": "C0010977", "name": "C0010977#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [11, 12]}}
{"token": ["Contrary", "to", "LM", "24056", "sulfoxide", "and", "LM", "24056", "C3536897#ent", "<e1>", ",", "desmethyl", "LM", "24056", "is", "a", "more", "potent", "C0682875#ent", "<e2>", "LM", "24056", "."], "h": {"id": "C3536897", "name": "C3536897#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0682875", "name": "C0682875#ent", "pos": [18, 19]}}
{"token": ["encoding", "for", "the", "heavy", "subunit", "of", "the", "transporter", "protein", "C1420191#ent", "<e1>", ",", "were", "associated", "with", "I", "cystinuria", ",", "whereas", "type", "II", "C0010691#ent", "<e2>", "associated", "with", "mutations", "in", "the", "SLC7A9", "gene", "encoding", "for", "a", "light", "subunit", "C1420191#ent", "<e1>", "."], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [21, 22]}, "relation": "disease_has_associated_gene", "t": {"id": "C1420191", "name": "C1420191#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "the", "function", "of", "a", "basic", "and", "neutral", "amino", "acid", "transporter-like", "protein", "rBAT", ")", "which", "is", "a", "candidate", "gene", "for", "C0010691#ent", "<e1>", ",", "we", "analysed", "the", "C1420191#ent", "<e2>", "cystinuric", "patients", "."], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [21, 22]}, "relation": "disease_has_associated_gene", "t": {"id": "C1420191", "name": "C1420191#ent", "pos": [27, 28]}}
{"token": ["A", "71-year-old", "man", ",", "who", "had", "a", "history", "of", "a", "previous", "bullous", "drug", "reaction", "a", "C0038760#ent", "<e1>", ",", "began", "receiving", "an", "ophthalmic", "preparation", "that", "contained", "C0038670#ent", "<e2>"], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [15, 16]}, "relation": "chemical_structure_of", "t": {"id": "C0038670", "name": "C0038670#ent", "pos": [25, 26]}}
{"token": ["Sulfa", "antibiotics", "C0038760#ent", "<e1>", ")", "are", "derivatives", "of", "C0038670#ent", "<e2>", "that", "are", "widely", "used", "in", "veterinary", "medicine"], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [2, 3]}, "relation": "chemical_structure_of", "t": {"id": "C0038670", "name": "C0038670#ent", "pos": [8, 9]}}
{"token": ["Accordingly", ",", "we", "studied", "c-fos", ",", "c-jun", ",", "and", "C0086661#ent", "<e1>", "expression", "in", "C0268731#ent", "<e2>", "during", "the", "rapid", "phase", "of", "glomerular", "hypertrophy", "follows", "the", "onset", "of", "hyperglycemia", "in", "diabetic", "rats", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [13, 14]}}
{"token": ["C1416697#ent", "<e1>", "is", "negatively", "regulated", "by", "C0080054#ent", "<e2>", "phosphorylation", "during", "metaphase", "and", "becomes", "activated", "in", "anaphase", "when", "cleavage-furrow", "assembly", "commences", "."], "h": {"id": "C1416697", "name": "C1416697#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [6, 7]}}
{"token": ["Bronchial", "narrowing", "the", "major", "side", "effect", "inhaled", "C0030864#ent", "<e1>", "used", "for", "the", "prophylaxis", "and", "treatment", "of", "Pneumocystis", "carinii", "C1535939#ent", "<e2>", "."], "h": {"id": "C0030864", "name": "C0030864#ent", "pos": [7, 8]}, "relation": "may_prevent", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [18, 19]}}
{"token": ["Severe", "hemorrhagic", "pancreatitis", "in", "a", "patient", "with", "the", "acquired", "immunodeficiency", "syndrome", "AIDS", ")", "during", "C0030864#ent", "<e1>", "treatment", "for", "Pneumocystis", "carinii", "C1535939#ent", "<e2>", "."], "h": {"id": "C0030864", "name": "C0030864#ent", "pos": [14, 15]}, "relation": "may_prevent", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [20, 21]}}
{"token": ["Mouse", "models", "been", "described", "for", "loss", "of", "Fmrp", ",", "C1414872#ent", "<e1>", "and", "Fxr2p", ",", "the", "mouse", "C4277608#ent", "<e2>", "of", "FMRP", ",", "FXR1P", "and", "FXR2P", "."], "h": {"id": "C1414872", "name": "C1414872#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [16, 17]}}
{"token": ["The", "other", "C0991617#ent", "<e1>", "were", "without", "stimulatory", "effect", "on", "cAMP", ",", "although", "like", "C0037506#ent", "<e2>", "they", "may", "significantly", "affect", "normal", "intestinal", "cation", "glucose", "transport", "these", "conditions", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [13, 14]}}
{"token": ["These", "C0991617#ent", "<e1>", "failed", "to", "prevent", "C0037506#ent", "<e2>", "action", "on", "lysosomes", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [6, 7]}}
{"token": ["E.", "coli", "dinB", "C0012892#ent", "<e1>", "greatly", "increases", "spontaneous", "mutations", "when", "C3889446#ent", "<e2>", "."], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}}
{"token": ["The", "catalytic", "subunit", "human", "C0012892#ent", "<e1>", "pol", ")", "delta", "was", "C3889446#ent", "<e2>", "in", "an", "active", ",", "soluble", "form", "by", "the", "use", "of", "a", "baculovirus", "system", "insect", "cells"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}}
{"token": ["The", "purification", "of", "the", "C0012892#ent", "<e1>", "been", "hampered", "by", "the", "insolubility", "of", "the", "C3889446#ent", "<e2>", "enzyme", "in", "Escherichia", "coli", "cells"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [13, 14]}}
{"token": ["Evidence", "is", "accumulating", "to", "support", "poor", "oral", "health", "a", "risk", "factor", "systemic", "conditions", ",", "including", "cardiovascular", "diseases", "C1263960#ent", "<e1>", "adverse", "pregnancy", "outcomes", ",", "and", "C1535939#ent", "<e2>", "."], "h": {"id": "C1263960", "name": "C1263960#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [24, 25]}}
{"token": ["Liquid", "chromatography", "employed", "for", "the", "determination", "of", "C0071143#ent", "<e1>", "enantiomers", "and", "its", "oxidation", "product", "dehydropirlindole", "(", "C0220821#ent", "<e2>", ")", "."], "h": {"id": "C0071143", "name": "C0071143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0220821", "name": "C0220821#ent", "pos": [16, 17]}}
{"token": ["Clinical", "trial", "confirm", "that", "extended-release", "C0008809#ent", "<e1>", "is", "as", "safely", "used", "and", "effective", "as", "the", "conventional", ",", "immediate-release", "formulation", "of", "C0008809#ent", "<e1>", "in", "patients", "with", "uncomplicated", "C0042029#ent", "<e1>", ",", "complicated", "C0042029#ent", "<e1>", "or", "acute", "uncomplicated", "pyelonephritis"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [26, 27]}}
{"token": ["A", "woman", "with", "lupus", "nephritis", "high-dose", "prednisone", "presented", "with", "acute", "peripheral", "neuropathy", "2", "days", "of", "starting", "C0008809#ent", "<e1>", "for", "a", "C0042029#ent", "<e2>"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [20, 21]}}
{"token": ["To", "determine", "the", "efficacy", "of", "prophylactic", "C0008809#ent", "<e1>", "in", "preventing", "C0042029#ent", "<e2>", "by", "urodynamic", "study", "UDS", ")", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [10, 11]}}
{"token": ["The", "rest", "had", "hepatitis", ",", "alcoholic", "liver", "disease", "hypoproteinemia", ",", "C0018802#ent", "<e1>", "renal", "disease", "and", "multiple", "myeloma", "however", ",", "all", "lacked", "clinical", "evidence", "C2609268#ent", "<e2>"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2609268", "name": "C2609268#ent", "pos": [23, 24]}}
{"token": ["A", "gene", "locus", "C0027126#ent", "<e1>", "been", "mapped", "to", "C0795808#ent", "<e2>"], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0795808", "name": "C0795808#ent", "pos": [8, 9]}}
{"token": ["A", "common", "gene", "variant", "the", "heparin-binding", "domain", "HBD", ")", "of", "C4049722#ent", "<e1>", "ECSOD", ")", "may", "predispose", "human", "carriers", "to", "C0010054#ent", "<e2>"], "h": {"id": "C4049722", "name": "C4049722#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "emphasise", "the", "clinical", "variability", "associated", "with", "C0950122#ent", "<e1>", "support", "genetic", "heterogeneity", "the", "C0039082#ent", "<e2>", "."], "h": {"id": "C0950122", "name": "C0950122#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}}
{"token": ["Although", "we", "are", "still", "unable", "to", "clarify", "a", "phenotype-genotype", "relationship", "in", "C0950122#ent", "<e1>", "our", "data", "add", "to", "the", "list", "of", "mutations", "associated", "with", "C0039082#ent", "<e2>", "."], "h": {"id": "C0950122", "name": "C0950122#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [23, 24]}}
{"token": ["Association", "thus", "was", "demonstrated", "between", "activity", "of", "C0031667#ent", "<e1>", "ileal", "mucosa", "proneness", "to", "ileal", "inflammation", "C0156147#ent", "<e2>"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [15, 16]}}
{"token": ["The", "results", "suggest", "that", "raised", "C0031667#ent", "<e1>", "activity", "in", "patients", "with", "C0156147#ent", "<e2>", "ulcerative", "colitis", "mainly", "attributed", "to", "the", "two", "forms", "of", "phospholipase", "A2", "related", "to", "group", "II", "enzyme", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [11, 12]}}
{"token": ["Patients", "with", "concomitant", "Crohn's", "colitis", "in", "whom", "the", "risk", "of", "ileal", "recurrence", "particularly", "high", ",", "had", "greater", "C0031667#ent", "<e1>", "activity", "than", "C0156147#ent", "<e2>", "patients", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [21, 22]}}
{"token": ["The", "Bcr-Abl", "oncogene", "found", "in", "Philadelphia", "chromosome-positive", "myelogenous", "leukemia", "CML", ")", ",", "activates", "Ras", "and", "triggers", "the", "C0380051#ent", "<e1>", "SAPK", "or", "C1367731#ent", "<e2>", "JNK", "]", ")", "pathway", "."], "h": {"id": "C0380051", "name": "C0380051#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [21, 22]}}
{"token": ["Transient", "overexpression", "of", "C0380051#ent", "<e1>", "catalytically", "inactive", "C1367731#ent", "<e2>", "JNK", ")", "1", "and", "2", "inhibits", "TNF-induced", "transcription", "of", "an", "E-selectin", "but", "not", "a", "kappa", "B", "promoter-reporter", "gene", "."], "h": {"id": "C0380051", "name": "C0380051#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [7, 8]}}
{"token": ["This", "increased", "trafficking", "of", "C1412493#ent", "<e1>", "was", "suppressed", "by", "phospholipase", "C", "C1259877#ent", "<e2>", "PKC", ")", "inhibitors", "and", "a", "phorbol", "ester", "accelerated", "the", "trafficking", "of", "C1412493#ent", "<e1>", "to", "the", "membrane", "fraction"], "h": {"id": "C1412493", "name": "C1412493#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [11, 12]}}
{"token": ["The", "present", "study", "uses", "cell-based", "screening", "assays", "to", "assess", "the", "anticancer", "effects", "targeting", "phosphatidylinositol", "3-kinase-regulated", "integrin-linked", "kinase", "C0385469#ent", "<e1>", ")", "in", "combination", "with", "small-molecule", "inhibitors", "of", "Raf-1", "or", "C0257151#ent", "<e2>", "MEK", ")", "."], "h": {"id": "C0385469", "name": "C0385469#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0257151", "name": "C0257151#ent", "pos": [28, 29]}}
{"token": ["We", "then", "targeted", "endogenous", "C1417679#ent", "<e1>", ",", "encoding", "the", "dopamine", "(", "DAT", ")", "and", "C1420214#ent", "<e2>", "SERT", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420214", "name": "C1420214#ent", "pos": [14, 15]}}
{"token": ["C0950122#ent", "<e1>", "characterized", "by", "progressive", "glomerulopathy", "due", "to", "nonspecific", "focal", "and", "C0017668#ent", "<e2>", "FSGS", ")", ",", "46,XY", "sex", "reversal", "and", "the", "development", "of", "gonadoblastoma", "from", "dysgenetic", "gonads"], "h": {"id": "C0950122", "name": "C0950122#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "immunohistochemistry", "showed", "preferential", "accumulation", "of", "C0919432#ent", "<e1>", "in", "the", "nuclei", "of", "glomerular", "and", "tubular", "cells", "C0011847#ent", "<e2>", "."], "h": {"id": "C0919432", "name": "C0919432#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [17, 18]}}
{"token": ["These", "interactions", "not", "only", "allow", "colonization", "of", "the", "human", "mucosa", "but", "also", "stimulate", "cellular", "signaling", "cascades", "phosphatidylcholine-dependent", "phospholipase", "C", "C0599122#ent", "<e1>", "protein", "kinase", "C", "epithelial", "cells", "and", "Src-related", "kinases", ",", "Rac1", ",", "C1505379#ent", "<e2>", "and", "Jun", "N-terminal", "kinase", "phagocytic", "cells"], "h": {"id": "C0599122", "name": "C0599122#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1505379", "name": "C1505379#ent", "pos": [32, 33]}}
{"token": ["Specifically", ",", "C2936882#ent", "<e1>", "and", "androgen", "alter", "neurite", "outgrowth", "C0029134#ent", "<e2>", "spine", "development", ",", "and", "synaptogenesis", "in", "the", "limbic", "system", "spinal", "cord"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029134", "name": "C0029134#ent", "pos": [9, 10]}}
{"token": ["The", "activity", "of", "citrin", "and", "C1417827#ent", "<e1>", "as", "aspartate/glutamate", "exchangers", "was", "stimulated", "by", "C0001477#ent", "<e2>", "the", "external", "side", "of", "the", "inner", "mitochondrial", "membrane", "where", "the", "Ca(2+)-binding", "domains", "of", "these", "proteins", "are", "localized", "."], "h": {"id": "C1417827", "name": "C1417827#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [13, 14]}}
{"token": ["Two", "other", "C1417679#ent", "<e1>", "with", "mixed", "support", "as", "genetic", "risk", "factors", "AD", ",", "A2M", "C3813120#ent", "<e2>", ")", "and", "LRP", "(", "low-density", "lipoprotein", "receptor-related", "protein", ",", "have", "not", "been", "studied", "in", "relation", "to", "memory", "among", "nondemented", "adults", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3813120", "name": "C3813120#ent", "pos": [14, 15]}}
{"token": ["The", "most", "widely", "prescribed", "oral", "antipsychotic", "was", "found", "to", "be", "C0008286#ent", "<e1>", "closely", "followed", "by", "thioridazine", "and", "C0040979#ent", "<e2>", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [17, 18]}}
{"token": ["C0008286#ent", "<e1>", ",", "verapamil", ",", "and", "C0040979#ent", "<e2>", "increased", "the", "cellular", "accumulation", "and", "cytotoxicity", "of", "DNR", "and", "THP-ADR", "but", "had", "no", "major", "effect", "on", "N-trifluoroacetyl-adriamycin-14-valerate", "fluorescence", "cytotoxicity", "in", "P388/R", "cells", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [6, 7]}}
{"token": ["The", "effect", "of", "pretreatment", "by", "phenothiazines", "--", "C0008286#ent", "<e1>", "(", "CPR", ")", "/Spofa/", "and", "C0040979#ent", "<e2>", "(", "TFP", ")", "/Smith", "Kline", "and", "French/", "on", "reperfusion", "injury", "ischemic", "myocardium", "studied", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [14, 15]}}
{"token": ["Dermatopontin", "reacted", "with", "C0057252#ent", "<e1>", "with", "an", "apparent", "C1705240#ent", "<e2>", "of", "100", "nM", "in", "a", "solid-phase", "assay", "."], "h": {"id": "C0057252", "name": "C0057252#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [8, 9]}}
{"token": ["Antacids", "and", "C1268903#ent", "<e1>", "used", "for", "C0400807#ent", "<e2>", "prophylaxis", ",", "but", "histamine", "H2-receptor", "antagonists", "are", "now", "regarded", "as", "the", "standard", "of", "care"], "h": {"id": "C1268903", "name": "C1268903#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0400807", "name": "C0400807#ent", "pos": [6, 7]}}
{"token": ["C1418296#ent", "<e1>", "and", "DCoHalpha", "are", "bifunctional", "proteins", "function", "as", "4a-hydroxytetrahydrobiopterin", "dehydratases", "as", "C1422492#ent", "<e2>", "of", "HNF1alpha-dependent", "transcription", "."], "h": {"id": "C1418296", "name": "C1418296#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [12, 13]}}
{"token": ["In", "order", "to", "explore", "the", "therapeutic", "effect", "tongxinluo", "capsule", "(", "TXLC", ")", "on", "C1442864#ent", "<e1>", "the", "influence", "on", "plasma", "endothelin", "ET-1", ")", "level", "of", "the", "C1254351#ent", "<e2>", "was", "observed", "."], "h": {"id": "C1442864", "name": "C1442864#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [25, 26]}}
{"token": ["When", "the", "desired", "blood", "pressure", "target", "is", "obtained", ",", "cardiovascular", "outcome", "probably", "also", "progression", "of", "C1442864#ent", "<e1>", "significantly", "improved", "independently", "of", "a", "specific", "C1254351#ent", "<e2>", "."], "h": {"id": "C1442864", "name": "C1442864#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [23, 24]}}
{"token": ["It", "is", "concluded", ",", "that", "in", "cases", "of", "C1442864#ent", "<e1>", "ACE-inhibitor", "is", "the", "\"", "C1254351#ent", "<e2>", "of", "choice", "\"", "for", "treatment", "of", "hypertension", "."], "h": {"id": "C1442864", "name": "C1442864#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["Additional", "studies", "assessing", "the", "long-term", "effect", "of", "different", "antihypertensive", "agents", "the", "evolution", "of", "early", "C1442864#ent", "<e1>", "needed", "before", "the", "superiority", "of", "any", "C1254351#ent", "<e2>", "can", "be", "claimed", "."], "h": {"id": "C1442864", "name": "C1442864#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [22, 23]}}
{"token": ["Leukocyte", "entrapment", "in", "the", "retinal", "capillaries", "cause", "C1096458#ent", "<e1>", "dysfunction", ",", "in", "turn", "causing", "C0011884#ent", "<e2>"], "h": {"id": "C1096458", "name": "C1096458#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [14, 15]}}
{"token": ["We", "report", "a", "case", "of", "C1096458#ent", "<e1>", "a", "patient", "with", "severe", "C0011884#ent", "<e2>", "retrobulbar", "injection", "of", "lidocaine", "."], "h": {"id": "C1096458", "name": "C1096458#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [11, 12]}}
{"token": ["Each", "C1333522#ent", "<e1>", "segregated", "into", "two", "active", "fractions", "after", "high-pressure", "reverse-phase", "liquid", "chromatography", "HPLC", ")", ",", "suggesting", "the", "presence", "of", "two", "C1333522#ent", "<e1>", "components", "in", "C3542918#ent", "<e1>", "for", "each", "antigen", "specificity"], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3542918", "name": "C3542918#ent", "pos": [25, 26]}}
{"token": ["Its", "physiochemical", "properties", "structure", "were", "determined", "by", "methods", "previously", "employed", "to", "characterize", "human", "PPD-specific", "C1333522#ent", "<e1>", "isolated", "from", "dialyzable", "leukocyte", "extracts", "(", "C3542918#ent", "<e2>", ")", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3542918", "name": "C3542918#ent", "pos": [22, 23]}}
{"token": ["Uromodulin", "(", "UMOD", ")", "malfunction", "has", "been", "found", "in", "a", "range", "of", "autosomal", "dominant", "tubulointerstitial", "nephropathies", "associated", "with", "hyperuricaemia", ",", "C0003868#ent", "<e1>", "medullary", "cysts", "renal", "failure-labelled", "as", "C0268113#ent", "<e2>", "medullary", "cystic", "disease", "type", "2", "glomerulocystic", "kidney", "disease"], "h": {"id": "C0003868", "name": "C0003868#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0268113", "name": "C0268113#ent", "pos": [27, 28]}}
{"token": ["C0079471#ent", "<e1>", "expression", "in", "the", "transgenic", "mouse", "C0023899#ent", "<e2>", "might", "counteract", "cell-cycle", "progression", "by", "c-myc", "and", "CD1", "."], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}}
{"token": ["This", "mutation", "profile", "was", "similar", "to", "that", "identified", "for", "the", "C0079471#ent", "<e1>", "the", "spontaneous", "liver", "tumors", "suggests", "that", "methylene", "chloride", "in", "C0023899#ent", "<e2>", "by", "promoting", "cells", "with", "spontaneous", "lesions"], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [21, 22]}}
{"token": ["In", "blank", "calf", "urine", "the", "detection", "limits", ",", "mean", "background", "+", "3", "times", "the", "standard", "deviation", "are", "1.3", "(", "C0015840#ent", "<e1>", ")", "and", "2.6", "ng", "ml-1", "(", "C0072954#ent", "<e2>", ")", "."], "h": {"id": "C0015840", "name": "C0015840#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0072954", "name": "C0072954#ent", "pos": [27, 28]}}
{"token": ["Within", "the", "matrix", "of", "C1439329#ent", "<e1>", "we", "detected", "transcriptional", "co-activators", "and", "TATA-box", "binding", "protein", "C1705304#ent", "<e2>", ")", "."], "h": {"id": "C1439329", "name": "C1439329#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [14, 15]}}
{"token": ["In", "papillary", "muscles", "increases", "in", "contractile", "force", "induced", "by", "C0078595#ent", "<e1>", "and", "isoproterenol", "were", "depressed", "markedly", "in", "the", "presence", "of", "C0006945#ent", "<e2>", "or", "adenosine", "."], "h": {"id": "C0078595", "name": "C0078595#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [20, 21]}}
{"token": ["If", "this", "be", "the", "case", ",", "then", "C1136254#ent", "<e1>", "against", "these", "anaerobes", "wih", "C0025872#ent", "<e2>", "was", "indicated", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [13, 14]}}
{"token": ["The", "efficacy", "of", "the", "triple", "therapy", "contains", "C0025872#ent", "<e1>", "as", "one", "of", "the", "C1136254#ent", "<e2>", "eradication", "of", "the", "C0025872#ent", "<e1>", "susceptible", "and", "the", "C0025872#ent", "<e1>", "resistant", "strains", "was", "also", "assessed", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [7, 8]}}
{"token": ["We", "describe", "the", "characterization", "of", "liposomes", "loaded", "with", "C1136254#ent", "<e1>", "ampicillin", "and", "C0025872#ent", "<e2>", ")", "and", "the", "quantification", "of", "the", "interactions", "between", "such", "formulations", "and", "bacteria", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [8, 9]}, "relation": "therapeutic_class_of", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [12, 13]}}
{"token": ["Chronic", "genital", "edema", "secondary", "to", "C0024215#ent", "<e1>", "and", "chylous", "reflux", "a", "23-yr-old", "man", "with", "C0028326#ent", "<e2>", "investigated", "by", "99mTc", "sulfur", "nanocolloid", "lymphoscintigraphy", "and", "bipedal", "contrast", "lymphangiography"], "h": {"id": "C0024215", "name": "C0024215#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028326", "name": "C0028326#ent", "pos": [14, 15]}}
{"token": ["Thus", "volume-induced", "secretion", "of", "C1417807#ent", "<e1>", "is", "not", "suppressed", "by", "C0280858#ent", "<e2>", ",", "but", "is", "directly", "enhanced", "by", "low-dose", "ET-1", ",", "known", "to", "activate", "the", "phosphoinositide", "pathway"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [10, 11]}}
{"token": ["These", "studies", "have", "demonstrated", "that", "calcium", "ions", "an", "important", "role", "in", "C1417807#ent", "<e1>", "secretion", "with", "reversal", "by", "calcium", "antagonist", "C0280858#ent", "<e2>", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [19, 20]}}
{"token": ["The", "adaptation", "of", "the", "secretory", "rate", "C1417807#ent", "<e1>", "repeated", "adequate", "stimuli", "and", "the", "influence", "of", "the", "calcium", "antagonist", "C0280858#ent", "<e2>", "on", "the", "release", "of", "C1417807#ent", "<e1>", "investigated", "in", "16", "patients", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [18, 19]}}
{"token": ["MEGF10", "has", "the", "overall", "domain", "organization", "of", "C1424154#ent", "<e1>", ",", "containing", "a", "signal", "peptide", "a", "EMI", "domain", "17", "atypical", "C1705447#ent", "<e2>", "a", "transmembrane", "domain", "and", "a", "cytoplasmic", "domain", "NPXY", "and", "YXXL", "motifs", "."], "h": {"id": "C1424154", "name": "C1424154#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705447", "name": "C1705447#ent", "pos": [19, 20]}}
{"token": ["C1704928#ent", "<e1>", "is", "the", "normal", "cellular", "homolog", "the", "v-abl", "transforming", "gene", "C1412097#ent", "<e2>"], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [11, 12]}}
{"token": ["It", "was", "also", "possible", "to", "differentiate", "between", "C1704928#ent", "<e1>", "and", "PDGFR", "kinase", "inhibition", ",", "with", "compound", "22", "selective", "towards", "C1412097#ent", "<e2>", "and", "23", "selective", "for", "PDGFR", "."], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [19, 20]}}
{"token": ["Similarly", ",", "C1704928#ent", "<e1>", "exon", "2", "alternatively", "spliced", "to", "either", "of", "two", "upstream", "C1704928#ent", "<e1>", "exons", "(", "1a", "or", "1b", ")", "in", "C1412097#ent", "<e1>", "."], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [22, 23]}}
{"token": ["Indications", "for", "examination", "were", "mostly", "neoplastic", "diseases", "C1456654#ent", "<e1>", "the", "CNS", ",", "including", "C0026769#ent", "<e2>", "other", "disorders", "of", "the", "CNS", ";", "and", "disk", "diseases"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [13, 14]}}
{"token": ["It", "is", "striking", "that", "pain", "has", "not", "been", "examined", "in", "C1456654#ent", "<e1>", "the", "central", "nervous", "system", "a", "high", "risk", "cognitive", "impairment", "as", "Parkinson's", "disease", "C0026769#ent", "<e2>"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [24, 25]}}
{"token": ["It", "has", "also", "been", "implicated", "in", "C1456654#ent", "<e1>", "in", "particular", ",", "C0026769#ent", "<e2>", "Parkinson's", "Alzheimer's", "diseases"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [11, 12]}}
{"token": ["It", "provides", "a", "link", "between", "the", "activated", "Sev", "receptor", "C4225412#ent", "<e1>", ",", "a", "guanine", "nucleotide", "release", "factor", "activates", "C1428880#ent", "<e2>", "."], "h": {"id": "C4225412", "name": "C4225412#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1428880", "name": "C1428880#ent", "pos": [18, 19]}}
{"token": ["Transcription", "of", "C2606868#ent", "<e1>", "was", "studied", "by", "transfecting", "NGFI-B", "and", "steroidogenic", "factor", "1", "C1421652#ent", "<e2>", ")", "expression", "vectors", "reporter", "constructs", "prepared", "with", "human", "steroidogenic", "acute", "regulatory", "protein", "cholesterol", "side-chain", "cleavage", "and", "HSD3B2", "genes"], "h": {"id": "C2606868", "name": "C2606868#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421652", "name": "C1421652#ent", "pos": [13, 14]}}
{"token": ["The", "presence", "of", "small", "A.", "fabae", "colonies", "had", "no", "significant", "effect", "on", "C1335833#ent", "<e1>", "attendance", "of", "C0004698#ent", "<e2>", ",", "which", "remained", "at", "the", "same", "level", "as", "that", "on", "plants", "without", "A.", "fabae", "."], "h": {"id": "C1335833", "name": "C1335833#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004698", "name": "C0004698#ent", "pos": [16, 17]}}
{"token": ["RFLP", "of", "16S", "rDNA", "divided", "the", "isolates", "into", "four", "different", "groups", "with", "MspI", ",", "two", "with", "C2697833#ent", "<e1>", "and", "two", "with", "C0059174#ent", "<e2>"], "h": {"id": "C2697833", "name": "C2697833#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0059174", "name": "C0059174#ent", "pos": [21, 22]}}
{"token": ["The", "mechanism", "of", "C1415619#ent", "<e1>", "activation", "by", "a", "cell", "wall", "alteration", "is", "via", "the", "exchange", "factor", "C0380093#ent", "<e2>", "and", "could", "be", "analogous", "to", "signalling", "by", "integrin", "receptors", "mammalian", "cells"], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0380093", "name": "C0380093#ent", "pos": [16, 17]}}
{"token": ["However", ",", "a", "SNP", "(", "rs2072658", ")", "located", "immediately", "upstream", "of", "C1413408#ent", "<e1>", "was", "associated", "with", "initial", "subjective", "response", "both", "C0001975#ent", "<e2>", "and", "tobacco", "."], "h": {"id": "C1413408", "name": "C1413408#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [20, 21]}}
{"token": ["The", "TFA-type", "C1421688#ent", "<e1>", "to", "C2H2-type", "zinc", "finger", "protein", "family", "the", "finger", "structure", "C1334107#ent", "<e2>", "-", "4CX3FX5LX2HX3", "-", "5H", "."], "h": {"id": "C1421688", "name": "C1421688#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334107", "name": "C1334107#ent", "pos": [13, 14]}}
{"token": ["In", "C1416746#ent", "<e1>", "cultures", ",", "there", "were", "no", "effects", "of", "IL-1", ",", "C3537249#ent", "<e2>", "or", "their", "combination", "on", "IL-1alpha", "protein"], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3537249", "name": "C3537249#ent", "pos": [12, 13]}}
{"token": ["In", "cocultures", "with", "either", "WT", "or", "C1416746#ent", "<e1>", "osteoblasts", ",", "treatment", "with", "C3537249#ent", "<e2>", "receptor", "activator", "NF-kappaB", "ligand", "mRNA", "by", "17-", ",", "19-", ",", "or", "3.5-fold", ",", "respectively", "."], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3537249", "name": "C3537249#ent", "pos": [12, 13]}}
{"token": ["Degenerative-dystrophic", "lesions", "(", "C0038020#ent", "<e1>", "intervertebral", "osteochondrosis", "of", "the", "thoracic", "spine", "with", "C2745963#ent", "<e2>", "the", "costovertebral", "and", "costotransverse", "articulations", "lead", "to", "neurodystrophy", "of", "the", "gastric", "and", "duodenal", "mucosa", "chronic", "stimulation", "osteophytes", "of", "the", "thoracic", "sympathetic", "ganglia"], "h": {"id": "C0038020", "name": "C0038020#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2745963", "name": "C2745963#ent", "pos": [12, 13]}}
{"token": ["Given", "the", "likely", "commonalities", "in", "the", "underlying", "cellular", "and", "molecular", "mechanisms", "it", "is", "not", "surprising", "that", "some", "antiepileptic", "drugs", "including", "C0080356#ent", "<e1>", ",", "topiramate", ",", "and", "gabapentin", ",", "are", "effective", "C0355614#ent", "<e2>"], "h": {"id": "C0080356", "name": "C0080356#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0355614", "name": "C0355614#ent", "pos": [30, 31]}}
{"token": ["Transcriptional", "repression", "the", "C0525036#ent", "<e1>", "distinct", "DNA", "sequences", "contribute", "to", "the", "C0079427#ent", "<e2>", "the", "Ink4a/Arf", "locus", "."], "h": {"id": "C0525036", "name": "C0525036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "upregulation", "of", "the", "C0525036#ent", "<e1>", "downregulation", "of", "C0079427#ent", "<e2>", "E-cadherin", "also", "occurs", "in", "the", "(pre)neoplastic", "state", "."], "h": {"id": "C0525036", "name": "C0525036#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [9, 10]}}
{"token": ["C0398738#ent", "<e1>", "is", "an", "C1420033#ent", "<e2>", "binds", "MEK", "kinase", "2", "MEKK2", ")", ",", "a", "mitogen-activated", "protein", "kinase", "MAPK", ")", "kinase", "kinase", "the", "extracellular", "signal-regulated", "kinase", "5", "ERK5", ")", "and", "JNK", "pathways"], "h": {"id": "C0398738", "name": "C0398738#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420033", "name": "C1420033#ent", "pos": [4, 5]}}
{"token": ["Biochemical", "disturbances", "common", "to", "C2936883#ent", "<e1>", "folate", "deficiency", "investigated", "in", "leukocytes", "from", "patients", "with", "C0342704#ent", "<e2>"], "h": {"id": "C2936883", "name": "C2936883#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0342704", "name": "C0342704#ent", "pos": [14, 15]}}
{"token": ["C1424637#ent", "<e1>", "had", "Arf", "C1419277#ent", "<e2>", "activity", "toward", "Arf1>Arf5>Arf6", "."], "h": {"id": "C1424637", "name": "C1424637#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419277", "name": "C1419277#ent", "pos": [4, 5]}}
{"token": ["Side", "effects", "C0030554#ent", "<e1>", ",", "sedation", ",", "headaches", ",", "and", "C0426576#ent", "<e2>", "common", "."], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [10, 11]}}
{"token": ["Patients", "generally", "presented", "with", "neurologic", "symptoms", "as", "C0030554#ent", "<e1>", ",", "vertigo", ",", "and", "ataxia", ",", "in", "addition", "to", "C0426576#ent", "<e2>", "as", "diarrhea", ",", "abdominal", "pain", "nausea", ",", "and", "vomiting", "."], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [18, 19]}}
{"token": ["This", "defect", "is", "due", "to", "the", "presence", "of", "abnormally", "high", "levels", "of", "the", "C0055288#ent", "<e1>", "CFI", ")", "in", "serums", "of", "patients", "with", "C0023890#ent", "<e2>"], "h": {"id": "C0055288", "name": "C0055288#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [22, 23]}}
{"token": ["The", "purpose", "of", "these", "experiments", "was", "to", "characterize", "the", "physiological", "role", "of", "a", "second", "t-SNARE", ",", "soluble", "N-ethylmaleimide-sensitive", "factor", "attachment", "protein", ",", "a", "homologue", "of", "the", "C4284285#ent", "<e1>", "in", "regulated", "exocytosis", "of", "C0379099#ent", "<e2>"], "h": {"id": "C4284285", "name": "C4284285#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [32, 33]}}
{"token": ["In", "addition", "to", "Jaks", ",", "several", "other", "proteins", "are", "rapidly", "phosphorylated", "on", "tyrosine", "residues", "in", "a", "RANTES-dependent", "manner", ",", "including", "the", "C0065344#ent", "<e1>", ",", "which", "associates", "with", "C1334292#ent", "<e2>", "."], "h": {"id": "C0065344", "name": "C0065344#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1334292", "name": "C1334292#ent", "pos": [27, 28]}}
{"token": ["IDB", "induced", "selective", "translocation", "of", "C2987025#ent", "<e1>", ",", "-epsilon", ",", "and", "-theta", "and", "C1538716#ent", "<e2>", "from", "the", "cytosolic", "fraction", "the", "particulate", "fraction", "induced", "morphologically", "typical", "apoptosis", "through", "de", "novo", "synthesis", "of", "macromolecules", "."], "h": {"id": "C2987025", "name": "C2987025#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1538716", "name": "C1538716#ent", "pos": [13, 14]}}
{"token": ["Two", "insertions", ",", "one", "in", "exon", "IIIa", "in", "a", "C2931196#ent", "<e1>", "patient", "and", "the", "other", "in", "exon", "IIIc", "in", "a", "C0220658#ent", "<e2>", "patient", ",", "were", "observed", "."], "h": {"id": "C2931196", "name": "C2931196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220658", "name": "C0220658#ent", "pos": [20, 21]}}
{"token": ["avr-15", ",", "a", "C0079429#ent", "<e1>", "that", "confers", "C0022322#ent", "<e2>", "sensitivity", "on", "worms", ",", "is", "necessary", "postsynaptically", "for", "a", "functional", "M3", "synapse", "for", "the", "hyperpolarizing", "effect", "of", "glutamate", "on", "pharyngeal", "muscle"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022322", "name": "C0022322#ent", "pos": [7, 8]}}
{"token": ["To", "isolate", "a", "C0079429#ent", "<e1>", "for", "stimulating", "C0022322#ent", "<e2>", "production", ",", "a", "genomic", "library", "Streptomyces", "avermitilis", "ATCC", "31267", "was", "constructed", "in", "Streptomyces", "lividans", "TK21", "as", "the", "host", "strain"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022322", "name": "C0022322#ent", "pos": [7, 8]}}
{"token": ["C0085207#ent", "<e1>", "not", "other", "C0021053#ent", "<e2>", "be", "a", "risk", "factor", "childhood", "cancer"], "h": {"id": "C0085207", "name": "C0085207#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [4, 5]}}
{"token": ["Interactions", "between", "IR", ",", "C1705297#ent", "<e1>", "and", "regulatory", "subunits", "of", "the", "C0089793#ent", "<e2>", "PI", "3'-kinase", ")", "were", "characterized", "in", "the", "present", "study", "in", "liver", "and", "muscles", "of", "chickens", "submitted", "to", "various", "nutritional", "states"], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "17beta-estradiol-bound", "estrogen", "receptor", "inhibit", "nuclear", "factor", "kappaB-dependent", "transcription", "of", "RANTES", "gene", "by", "competing", "with", "C1420556#ent", "<e1>", "for", "limiting", "amounts", "of", "C0256079#ent", "<e2>"], "h": {"id": "C1420556", "name": "C1420556#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0256079", "name": "C0256079#ent", "pos": [24, 25]}}
{"token": ["Both", "C1420556#ent", "<e1>", "and", "p53", "depend", "upon", "the", "C0256079#ent", "<e2>", "CBP", ")", "for", "maximal", "activity"], "h": {"id": "C1420556", "name": "C1420556#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0256079", "name": "C0256079#ent", "pos": [8, 9]}}
{"token": ["Following", "treatment", "of", "L1210", "cells", "with", "high", "concentrations", "of", "activated", "HMM", "and", "C0070302#ent", "<e1>", ",", "there", "were", "no", "DNA", "single-strand", "breaks", "interstrand", "cross-links", "observed", "by", "C0002057#ent", "<e2>", "only", "a", "low", "frequency", "of", "DNA-protein", "cross-links"], "h": {"id": "C0070302", "name": "C0070302#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002057", "name": "C0002057#ent", "pos": [25, 26]}}
{"token": ["In", "mice", ",", "enhancers", "of", "the", "C1334091#ent", "<e1>", "located", "up", "to", "260", "kb", "C0087071#ent", "<e2>", "to", "the", "gene", "."], "h": {"id": "C1334091", "name": "C1334091#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0087071", "name": "C0087071#ent", "pos": [13, 14]}}
{"token": ["These", "results", "showed", "that", "the", "spirochetes", "were", "capable", "of", "inducing", "C0014335#ent", "<e1>", "in", "deer", "and", "this", "intestinal", "C0037974#ent", "<e2>", "already", "be", "prevalent", "among", "wild", "sika", "deer", "in", "Japan", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037974", "name": "C0037974#ent", "pos": [17, 18]}}
{"token": ["The", "activation", "of", "a", "C1956039#ent", "<e1>", "an", "endogenous", "C1947941#ent", "<e2>", "is", "described", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [8, 9]}}
{"token": ["The", "nature", "of", "the", "protein", "phosphatases", "in", "the", "regulation", "of", "glycolysis/gluconeogenesis", ",", "fatty", "acid", "synthesis", "and", "cholesterol", "synthesis", "rat", "C0023899#ent", "<e1>", "has", "been", "investigated", "using", "C1418610#ent", "<e2>", "ATP-citrate", "lyase", "acetyl-CoA", "carboxylase", "hydroxymethylglutaryl-CoA", "reductase", "substrates", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418610", "name": "C1418610#ent", "pos": [25, 26]}}
{"token": ["In", "vitro", "studies", "demonstrated", "that", "carbuterol", "was", "a", "direct", "acting", "beta-adrenergic", "agonist", "not", "dependent", "on", "endogenous", "C3536742#ent", "<e1>", "release", ",", "and", "was", "devoid", "of", "C0001641#ent", "<e2>"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [24, 25]}}
{"token": ["Data", "on", "three", "patients", "with", "C0040128#ent", "<e1>", "that", "RBC-T", "values", "were", "increased", "in", "C0020550#ent", "<e2>", "and", "decreased", "in", "hypothyroidism", ",", "whereas", "the", "cytosol/cytosol", "+", "membrane-ratio", "was", "unaltered", "."], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [13, 14]}}
{"token": ["The", "clinical", "picture", "seen", "in", "C0040128#ent", "<e1>", "as", "a", "rule", "occurring", "in", "C0020550#ent", "<e2>", ",", "rarely", "in", "hypothyroid", "or", "euthyroid", "states", "."], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [12, 13]}}
{"token": ["The", "results", "showed", "that", "the", "women", "with", "C0040128#ent", "<e1>", "hypothyroidism", "or", "C0020550#ent", "<e2>", ")", "had", "higher", "plasma", "leptin", "concentrations", "than", "the", "normal", "controls", "p", "<", "0.05", ")", "."], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "identify", "human", "C1422104#ent", "<e1>", "as", "a", "C1417756#ent", "<e2>", "show", "that", "C1422104#ent", "<e1>", "preferentially", "binds", "the", "transcribed", "region", "ribosomal", "DNA", "repress", "the", "transcription", "of", "ribosomal", "RNA", "genes"], "h": {"id": "C1422104", "name": "C1422104#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417756", "name": "C1417756#ent", "pos": [8, 9]}}
{"token": ["HBV", "DNA", "was", "detected", "in", "10", "patients", ":", "3", "with", "acute", "hepatitis", "4", "asymptomatic", "hepatitis", "B", "surface", "antigen", "HBsAg", ")", "carriers", ",", "1", "with", "chronic", "active", "hepatitis", "1", "with", "C1623038#ent", "<e1>", ",", "and", "1", "with", "C0543697#ent", "<e2>"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0543697", "name": "C0543697#ent", "pos": [35, 36]}}
{"token": ["The", "activity", "of", "some", "iodine", "products", "at", "the", "second", "and", "third", "incremental", "addition", "of", "microorganisms", ";", "the", "C0055463#ent", "<e1>", "and", "the", "phenolic", "compounds", "inactivated", "by", "C0086376#ent", "<e2>", "at", "the", "third", "incremental", "addition", "."], "h": {"id": "C0055463", "name": "C0055463#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [25, 26]}}
{"token": ["Here", "we", "characterized", "the", "C3273624#ent", "<e1>", "which", "encodes", "the", "Drosophila", "orthologue", "of", "human", "C3273594#ent", "<e2>", ",", "a", "Parkin", "substrate"], "h": {"id": "C3273624", "name": "C3273624#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273594", "name": "C3273594#ent", "pos": [13, 14]}}
{"token": ["In", "good", "accord", "with", "data", "published", "from", "other", "sources", ",", "the", "authors", "'", "data", "suggest", "further", "restriction", "of", "direct", "procedures", "in", "view", "of", "the", "associated", "risk", "C0030305#ent", "<e1>", "in", "favor", "of", "C3273112#ent", "<e2>", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3273112", "name": "C3273112#ent", "pos": [31, 32]}}
{"token": ["Data", "were", "extracted", "from", "company", "clinical", "trial", "reports", "of", "randomised", "trials", "of", "C0538927#ent", "<e1>", "in", "osteoarthritis", "or", "C0003873#ent", "<e2>", "2", "weeks", "or", "more", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}}
{"token": ["This", "unexpected", "association", "of", "a", "chronic", "bowel", "inflammatory", "syndrome", "with", "prominent", "IgA", "abnormalities", "and", "severe", "C0004623#ent", "<e1>", "careful", "attention", "by", "physicians", "faced", "with", "young", "patients", "with", "C0025229#ent", "<e2>"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0025229", "name": "C0025229#ent", "pos": [26, 27]}}
{"token": ["Taken", "altogether", ",", "these", "observations", "suggest", "that", "C0108555#ent", "<e1>", "is", "structurally", "and", "functionally", "active", "it", "forms", "a", "complex", "with", "C1825534#ent", "<e2>", "."], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1825534", "name": "C1825534#ent", "pos": [19, 20]}}
{"token": ["Such", "a", "neurotoxic", "effect", "largely", "prevented", "by", "the", "monoamine", "oxidase", "B", "inhibitors", "pargyline", "and", "C0086130#ent", "<e1>", ",", "and", "the", "dopamine", "uptake", "inhibitors", "C0024977#ent", "<e2>", "and", "benztropine", "."], "h": {"id": "C0086130", "name": "C0086130#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024977", "name": "C0024977#ent", "pos": [22, 23]}}
{"token": ["Protection", "was", "not", "associated", "with", "inhibition", "of", "dopamine", "uptake", "by", "C0086130#ent", "<e1>", "because", "the", "dopamine", "uptake", "inhibitor", "C0024977#ent", "<e2>", "did", "not", "diminish", "BSO", "toxicity", "."], "h": {"id": "C0086130", "name": "C0086130#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024977", "name": "C0024977#ent", "pos": [17, 18]}}
{"token": ["This", "double-blinded", ",", "randomized", ",", "placebo-controlled", "study", "designed", "to", "investigate", "the", "acute", "effect", "C0015772#ent", "<e1>", "on", "regional", "blood", "supply", "collateral", "vascular", "resistance", "patients", "with", "C1306889#ent", "<e2>", "PAOD", ")", "."], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1306889", "name": "C1306889#ent", "pos": [24, 25]}}
{"token": ["C0030956#ent", "<e1>", "derived", "from", "proteolytic", "processing", "the", "C0085151#ent", "<e2>", "APP", ")", ",", "including", "the", "amyloid-beta", "peptide", "are", "important", "for", "the", "pathogenesis", "of", "Alzheimer's", "dementia"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [7, 8]}}
{"token": ["Alzheimer's", "disease", "AD", ")", "is", "a", "progressive", "neurodegenerative", "disorder", "is", "characterized", "by", "excessive", "deposits", "of", "aggregated", "beta-amyloid", "(", "Abeta", ")", "C0030956#ent", "<e1>", ",", "which", "are", "snippets", "of", "the", "C0085151#ent", "<e2>", "APP", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [28, 29]}}
{"token": ["The", "phosphorylation", "of", "a", "C0251914#ent", "<e1>", "rabbit", "liver", "by", "catalytic", "subunit", "C1956039#ent", "<e2>", "shown", ",", "and", "the", "protein", "was", "identified", "as", "cytochrome", "P-450", "LM2", "basis", "of", "comparative", "peptide-mapping", "."], "h": {"id": "C0251914", "name": "C0251914#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1956039", "name": "C1956039#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "SB203580", "did", "not", "overcome", "the", "inhibitory", "effect", "for", "proliferation", "of", "K562", "cells", "indicating", "that", "C1705633#ent", "<e1>", "MAPK", "activation", "by", "C0906802#ent", "<e2>", "does", "not", "affect", "cell", "numbers"], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [22, 23]}}
{"token": ["Importantly", ",", "pharmacological", "inhibition", "of", "C1705633#ent", "<e1>", "reverses", "the", "growth", "inhibitory", "of", "C0906802#ent", "<e2>", "on", "primary", "leukemic", "colony-forming", "unit", "granulocyte/macrophage", "progenitors", "from", "patients", "with", "CML", "."], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [12, 13]}}
{"token": ["Features", "associated", "with", "poor", "prognosis", "C1565662#ent", "<e1>", "cutaneous", "and", "C0152026#ent", "<e2>", "PAN", ";", "and", "neuropathy", ",", "weight", "loss", "histological", "evidence", "of", "vasculitis", "at", "rectal", "biopsy", "RV", "."], "h": {"id": "C1565662", "name": "C1565662#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0152026", "name": "C0152026#ent", "pos": [9, 10]}}
{"token": ["The", "clinical", "effects", "a", "new", "cardioselective", "beta-adrenergic", "blocking", "drug", "C0543447#ent", "<e1>", "SECTRAL", ")", ",", "were", "studied", "in", "18", "patients", "with", "C0002962#ent", "<e2>", "using", "graded", "treadmill", "testing", "to", "a", "modified", "Bruce", "protocol"], "h": {"id": "C0543447", "name": "C0543447#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [20, 21]}}
{"token": ["To", "investigate", "this", "process", ",", "we", "reconstructed", "the", "evolutionary", "history", "of", "C1723767#ent", "<e1>", ",", "a", "new", "primate", "chimeric", "gene", "from", "fusion", "of", "a", "C1334751#ent", "<e2>", "the", "transposase", "gene", "a", "mobile", "element"], "h": {"id": "C1723767", "name": "C1723767#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334751", "name": "C1334751#ent", "pos": [23, 24]}}
{"token": ["Therapeutic", "irrigation", "C0025405#ent", "<e1>", "solution", "was", "done", "in", "4", "cases", "of", "residual", "C0022650#ent", "<e2>", "a", "nephrostomy", "tube", "and", "in", "an", "infant", "with", "bladder", "cystine", "stones", "a", "Foley", "3-way", "catheter"], "h": {"id": "C0025405", "name": "C0025405#ent", "pos": [2, 3]}, "relation": "may_prevent", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [12, 13]}}
{"token": ["The", "action", "of", "carbachol", "is", "largely", "inhibited", "by", "the", "nicotinic", "antagonist", "hexamethonium", "3", "mM", ")", "and", "is", "completely", "blocked", "by", "a", "combination", "of", "C0062637#ent", "<e1>", "and", "the", "C0242947#ent", "<e2>", "6", "microM", ")", "."], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0242947", "name": "C0242947#ent", "pos": [27, 28]}}
{"token": ["The", "effects", "of", "three", "Ca2", "+", "C3494348#ent", "<e1>", "nicardipine", ",", "nimodipine", "and", "C0280858#ent", "<e2>", ",", "on", "CaCl2-", ",", "KCl-", "and", "noradrenaline-induced", "contractions", "were", "examined", "in", "isolated", "goat", "middle", "cerebral", "artery"], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [12, 13]}}
{"token": ["Previous", "investigations", "of", "authors", "abroad", "provided", "evidence", "of", "a", "reduction", "of", "portal", "pressure", "C3494348#ent", "<e1>", "of", "slow", "calcium", "channels", "group", "II", "C0280858#ent", "<e2>", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [21, 22]}}
{"token": ["We", "investigated", "the", "role", "of", "PDGF", "in", "C1704852#ent", "<e1>", "by", "inhibiting", "PDGF", "by", "imatinib", "(", "C0906802#ent", "<e2>", ")", ",", "a", "selective", "PDGF", "receptor", "tyrosine", "kinase", "inhibitor"], "h": {"id": "C1704852", "name": "C1704852#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [15, 16]}}
{"token": ["We", "compared", "the", "influence", "of", "exogenous", "C0027260#ent", "<e1>", "treatment", "with", "PKC", "agonist", "12-O-tetradecanoylphorbol-13-acetate", "TPA", ")", "on", "P-glycoprotein", "(", "C1422070#ent", "<e2>", ")", "function", "in", "various", "human", ",", "rat", "and", "dog", "cell", "lines"], "h": {"id": "C0027260", "name": "C0027260#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [18, 19]}}
{"token": ["C2605495#ent", "<e1>", "is", "an", "C2717970#ent", "<e2>", "has", "been", "implicated", "in", "the", "development", "of", "atherosclerotic", "lesions", "both", "animal", "models", "humans", "."], "h": {"id": "C2605495", "name": "C2605495#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [4, 5]}}
{"token": ["We", "therefore", "examined", "the", "influence", "of", "IL-10", "on", "PC-3", "ML", "production", "of", "C0165519#ent", "<e1>", "and", "the", "tissue", "inhibitors", "C1334706#ent", "<e2>", "(", "TIMP-1/2", ")", "."], "h": {"id": "C0165519", "name": "C0165519#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [18, 19]}}
{"token": ["This", "study", "showed", "that", "chronic", "lymphocytic", "leukaemia", "CLL", ")", "cells", "produce", "and", "secrete", "variable", "amounts", "of", "C0165519#ent", "<e1>", ",", "but", "no", "MMP-2", "or", "tissue", "inhibitor", "C1334706#ent", "<e2>", "TIMP-1", ")", "."], "h": {"id": "C0165519", "name": "C0165519#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [25, 26]}}
{"token": ["In", "particular", "C0002842#ent", "<e1>", "seem", "to", "have", "a", "protective", "role", "on", "C0003850#ent", "<e2>", "."], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [11, 12]}}
{"token": ["The", "role", "of", "endogenous", "estrogens", "and", "C0002842#ent", "<e1>", "and", "their", "potential", "interaction", "in", "C0003850#ent", "<e2>", "is", "not", "well", "understood", "."], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [13, 14]}}
{"token": ["was", "given", "as", "a", "pretreatment", "and", "diazepam", "was", "given", "5", "min", "after", "seizure", "onset", ",", "the", "32", "mg/kg", "dose", "of", "C0284906#ent", "<e1>", "significantly", "reduced", "the", "time", "for", "C0036572#ent", "<e2>"], "h": {"id": "C0284906", "name": "C0284906#ent", "pos": [20, 21]}, "relation": "may_prevent", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [27, 28]}}
{"token": ["The", "C2697656#ent", "<e1>", "and", "lipid", "A", "moiety", "of", "the", "two", "C1875400#ent", "<e2>", "of", "M.", "aeruginosa", "less", "active", "in", "toxicity", "in", "mice", "and", "Limulus", "test", "C2697656#ent", "<e1>", "of", "Salmonella", "abortus", "equi"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [10, 11]}}
{"token": ["Lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "from", "three", "human", "and", "four", "monkey", "C1875400#ent", "<e2>", "of", "Campylobacter", "jejuni", "extracted", "in", "high", "yields", "that", "revealed", "ladder-like", "structures", "in", "polyacrylamide", "gels", "direct", "silver", "staining"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [11, 12]}}
{"token": ["Exposure", "to", "lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "or", "even", "contamination", "of", "the", "C1875400#ent", "<e2>", "media", "with", "traces", "of", "C2697656#ent", "<e1>", "is", "known", "to", "play", "an", "important", "role", "in", "regulating", "cell", "function", "expression", "of", "receptors", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}}
{"token": ["C2697656#ent", "<e1>", "profiles", "of", "H.", "pylori", "C1875400#ent", "<e2>", "were", "assessed", "by", "gel", "electrophoresis", "Western", "blotting"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}}
{"token": ["We", "determined", "the", "binding", "domains", "sufentanil", "and", "C0009014#ent", "<e1>", "in", "the", "C1417965#ent", "<e2>", "comparing", "their", "binding", "affinities", "to", "seven", "mu/delta", "and", "six", "mu/kappa", "chimeric", "receptors", "those", "to", "mu", ",", "delta", "and", "kappa", "opioid", "receptors"], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417965", "name": "C1417965#ent", "pos": [11, 12]}}
{"token": ["The", "majority", "of", "affected", "members", ",", "who", "have", "only", "C0235222#ent", "<e1>", "normal", "biochemistry", "are", "clinically", "indistinguishable", "from", "patients", "with", "C0085580#ent", "<e2>"], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [19, 20]}}
{"token": ["Diabetes", "may", "be", "associated", "with", "C0235222#ent", "<e1>", "secondary", "to", "atherosclerosis", ",", "renal", "hypertension", "secondary", "to", "diabetic", "nephropathy", "and", "C0085580#ent", "<e2>"], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [18, 19]}}
{"token": ["To", "explore", "the", "effects", "of", "C0897640#ent", "<e1>", "on", "the", "proliferation", ",", "apoptosis", "and", "gene", "expression", "C1705526#ent", "<e2>", "and", "bcl-2", "in", "human", "gastric", "carcinoma", "cells", "."], "h": {"id": "C0897640", "name": "C0897640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [15, 16]}}
{"token": ["Arginine-vasopressin", "(", "C1334081#ent", "<e1>", ")", ",", "a", "differentiation", "inducer", ",", "rapidly", "activated", "C0388638#ent", "<e2>", "in", "a", "Rho-dependent", "way", ",", "as", "shown", "by", "almost", "total", "suppression", "of", "activation", "by", "C3", "exotoxin", "pretreatment", "."], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [12, 13]}}
{"token": ["On", "the", "other", "hand", ",", "C0021246#ent", "<e1>", "inhibited", "epidermal", "cyclooxygenase", "but", "quercetin", ",", "NDGA", "and", "C0050341#ent", "<e2>", "failed", "to", "inhibit", "it", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0050341", "name": "C0050341#ent", "pos": [15, 16]}}
{"token": ["A", "naturally", "occurring", "strain", "of", "bovine", "viral", "diarrhea", "BVD", ")", "virus", "was", "chemically", "treated", "to", "produce", "a", "C1516876#ent", "<e1>", "stable", ",", "temperature-sensitive", "mutant", ",", "designated", "C1419390#ent", "<e2>", "4350", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419390", "name": "C1419390#ent", "pos": [25, 26]}}
{"token": ["However", ",", "LexA/ER-LBD", "differentially", "modulated", "the", "C1421976#ent", "<e1>", "reporter", "gene", "expression", "when", "coexpressed", "with", "native", "C0968917#ent", "<e2>", ",", "RARs", ",", "or", "RXRs", "."], "h": {"id": "C1421976", "name": "C1421976#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0968917", "name": "C0968917#ent", "pos": [15, 16]}}
{"token": ["The", "C1416713#ent", "<e1>", "SFGSGFGGGY", "has", "been", "identified", "as", "a", "molecular", "mimic", "C0001056#ent", "<e2>", "(", "GlcNAc", ")", ",", "a", "known", "ligand", "of", "MBL", "."], "h": {"id": "C1416713", "name": "C1416713#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001056", "name": "C0001056#ent", "pos": [11, 12]}}
{"token": ["One", "interpretation", "of", "these", "data", "is", "that", "C1417815#ent", "<e1>", "produces", "some", "form", "of", "C0231218#ent", "<e2>", "or", "visceral", "illness", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [13, 14]}}
{"token": ["Locomotor", "activity", "similar", "after", "NRS", "and", "C1417815#ent", "<e1>", "antisera", "treatment", "(", "P", ">", "0.5", ")", "suggesting", "that", "C0231218#ent", "<e2>", "not", "responsible", "for", "the", "effects", "of", "C1417815#ent", "<e1>", "antisera", "on", "food", "intake", "body", "weight"], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "we", "concluded", "that", "vascular", "loops", "be", "a", "possible", "cause", "of", "C0015464#ent", "<e1>", "that", "this", "mechanism", "may", "involve", "C0085096#ent", "<e2>"], "h": {"id": "C0015464", "name": "C0015464#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [19, 20]}}
{"token": ["Earlier", "nonselective", "alpha", "1-adrenergic", "blocking", "drugs", "such", "as", "phentolamine", "and", "C0031441#ent", "<e1>", "are", "now", "restricted", "to", "the", "pharmacological", "management", "C0178469#ent", "<e2>", "and", "phaeochromocytoma", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0178469", "name": "C0178469#ent", "pos": [19, 20]}}
{"token": ["Other", "enhancers", ",", "such", "as", "DMSO", ",", "PEG", "400", ",", "C0001002#ent", "<e1>", ",", "urea", "and", "C1742019#ent", "<e2>", "showed", "little", "or", "no", "effect"], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [15, 16]}}
{"token": ["The", "effect", "of", "pentaformilgitoxin", "and", "C0011689#ent", "<e1>", "on", "heart", "rate", "blood", "pressure", "cardiac", "output", "compared", "in", "six", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0011689", "name": "C0011689#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["C1418858#ent", "<e1>", "is", "bound", "at", "the", "C3711161#ent", "<e2>", "the", "kinase", ",", "and", "a", "methylphenyl", "group", "C1418858#ent", "<e1>", "is", "inserted", "into", "an", "adjacent", "hydrophobic", "pocket"], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418858", "name": "C1418858#ent", "pos": [0, 1]}}
{"token": ["We", "find", "that", "Polo-like", "kinase", "1", "Plk1", ")", ",", "a", "protein", "kinase", "accumulates", "in", "mitosis", ",", "markedly", "stimulates", "the", "ligation", "of", "C1422079#ent", "<e1>", "to", "ubiquitin", "by", "purified", "C1412851#ent", "<e2>", ")", "."], "h": {"id": "C1422079", "name": "C1422079#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1412851", "name": "C1412851#ent", "pos": [27, 28]}}
{"token": ["Indeed", ",", "we", "demonstrate", "that", "C1422079#ent", "<e1>", "is", "a", "bona", "fide", "substrate", "of", "C1412851#ent", "<e2>", "."], "h": {"id": "C1422079", "name": "C1422079#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412851", "name": "C1412851#ent", "pos": [13, 14]}}
{"token": ["The", "clinical", "syndrome", "C0023896#ent", "<e1>", "the", "result", "of", "three", "factors", "--", "C1565489#ent", "<e2>", "portal", "hypertension", "the", "clinical", "consequences", "extrahepatic", "damage", "by", "alcohol", "."], "h": {"id": "C0023896", "name": "C0023896#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [11, 12]}}
{"token": ["The", "results", "suggest", "that", "increased", "platelet", "expression", "TNF-alpha", ",", "C1363984#ent", "<e1>", "and", "ICAM-1", "in", "C3273872#ent", "<e2>", "patients", "may", "constitute", "important", "markers", "of", "thrombocyte", "abnormalities", "the", "development", "of", "microvascular", "complications", "of", "diabetes", "mellitus"], "h": {"id": "C1363984", "name": "C1363984#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [14, 15]}}
{"token": ["The", "C1704657#ent", "<e1>", "plays", "an", "important", "role", "in", "the", "signal", "transduction", "pathway", "cell", "migration", "induced", "by", "bFGF", ",", "while", "bFGF", "can", "regulate", "the", "content", "of", "C1704657#ent", "<e1>", "in", "ECV-304", "cells", "at", "C0812327#ent", "<e1>", "level", "."], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [31, 32]}}
{"token": ["No", "variation", "in", "codons", "129", "and", "219", "has", "been", "observed", ":", "all", "chimpanzees", "were", "homozygous", "for", "the", "C1704823#ent", "<e1>", "which", "in", "humans", "increases", "susceptibility", "to", "C1418941#ent", "<e2>"], "h": {"id": "C1704823", "name": "C1704823#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418941", "name": "C1418941#ent", "pos": [25, 26]}}
{"token": ["A", "mixture", "of", "different", "fumaric", "acid", "esters", "C1414531#ent", "<e1>", ")", "is", "established", "for", "systemic", "therapy", "C0033860#ent", "<e2>", ",", "a", "frequent", "inflammatory", "skin", "disease"], "h": {"id": "C1414531", "name": "C1414531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "the", "mode", "of", "action", "of", "C1414531#ent", "<e1>", "and", "its", "clinical", "use", "C0033860#ent", "<e2>", "will", "be", "discussed", "."], "h": {"id": "C1414531", "name": "C1414531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [13, 14]}}
{"token": ["Using", "rtPCR", "with", "activin", "A-specific", "primers", "we", "detected", "activin", "mRNA", "in", "the", "choroid", "layer", "C1417775#ent", "<e1>", "and", "E19", "eyes", ",", "and", "from", "the", "C1256254#ent", "<e2>", "at", "C1417775#ent", "<e1>", "."], "h": {"id": "C1417775", "name": "C1417775#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1256254", "name": "C1256254#ent", "pos": [23, 24]}}
{"token": ["Pantothenate", "kinase", "C1412402#ent", "<e1>", ")", "is", "a", "rate-determining", "C0014442#ent", "<e2>", "in", "coenzyme", "A", "CoA", ")", "biosynthesis", "."], "h": {"id": "C1412402", "name": "C1412402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}}
{"token": ["Myoadenylate", "deaminase", "the", "C1412402#ent", "<e1>", "AMP", "deaminase", "EC", "3.5.4.6", ")", ",", "an", "C0014442#ent", "<e2>", "which", "plays", "a", "special", "role", "in", "energy", "metabolism", "skeletal", "muscle"], "h": {"id": "C1412402", "name": "C1412402#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["Adrenal", "insufficiency", "C0001403#ent", "<e1>", "may", "remain", "the", "only", "clinical", "manifestation", "C0162309#ent", "<e2>", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0162309", "name": "C0162309#ent", "pos": [10, 11]}}
{"token": ["Five", "boys", "had", "developed", "C0001403#ent", "<e1>", "to", "the", "diagnosis", "of", "C0162309#ent", "<e2>", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0162309", "name": "C0162309#ent", "pos": [10, 11]}}
{"token": ["Alternative", "routes", "for", "phosphorylation", "of", "nucleoside", "analogs", "also", "reviewed", ",", "such", "as", "the", "C1335408#ent", "<e1>", "capacity", "of", "5'-nucleotidase", "and", "C0030940#ent", "<e2>"], "h": {"id": "C1335408", "name": "C1335408#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [19, 20]}}
{"token": ["Considerable", "variation", "has", "been", "observed", "in", "the", "apparent", "tissue", "distribution", "of", "the", "C2348202#ent", "<e1>", "on", "the", "MoAb", "used", ",", "and", "hence", "the", "C1413212#ent", "<e2>", "epitope", "studied", "."], "h": {"id": "C2348202", "name": "C2348202#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413212", "name": "C1413212#ent", "pos": [22, 23]}}
{"token": ["Western", "blot", "analysis", "that", "the", "apparent", "molecular", "mass", "C2348202#ent", "<e1>", "different", "between", "muscle", "and", "developing", "nervous", "tissues", "suggesting", "that", "C1413212#ent", "<e2>", "glycosylation", "is", "tissue", "specific"], "h": {"id": "C2348202", "name": "C2348202#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413212", "name": "C1413212#ent", "pos": [19, 20]}}
{"token": ["However", ",", "human", "CMV-encoded", "C1423032#ent", "<e1>", "counteracts", "surface", "expression", "of", "several", "C3642258#ent", "<e2>", "intracellular", "retention", "."], "h": {"id": "C1423032", "name": "C1423032#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3642258", "name": "C3642258#ent", "pos": [11, 12]}}
{"token": ["The", "labelling", "efficiency", "of", "these", "gold", "particles", "conjugated", "with", "C0220304#ent", "<e1>", "in", "indirect", "immunolabelling", "experiments", "is", "investigated", "by", "labelling", "of", "C0005220#ent", "<e2>", "on", "ultrathin", "cryosections", "of", "Escherichia", "coli", "cells"], "h": {"id": "C0220304", "name": "C0220304#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [20, 21]}}
{"token": ["Results", "presented", "here", "have", "proven", "that", "the", "protease-sensitive", "site", "is", "viable", "in", "vitro", "the", "C0220304#ent", "<e1>", "and", "other", "chimeric", "protein", "C0005220#ent", "<e2>"], "h": {"id": "C0220304", "name": "C0220304#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [20, 21]}}
{"token": ["A", "tendency", "for", "an", "increase", "in", "C1334089#ent", "<e1>", "hormone", "concentrations", "in", "the", "C1421147#ent", "<e2>", "was", "detected", "on", "d", "17", "in", "bST-treated", "and", "cyclic", "cows", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421147", "name": "C1421147#ent", "pos": [12, 13]}}
{"token": ["The", "presence", "of", "C1334089#ent", "<e1>", "in", "the", "C1421147#ent", "<e2>", "throughout", "the", "oestrous", "cycle", "early", "pregnancy", "suggests", "a", "role", "of", "C1334089#ent", "<e1>", "in", "early", "pregnancy", "influencing", "both", "uterine", "growth", "embryonic", "survival"], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421147", "name": "C1421147#ent", "pos": [7, 8]}}
{"token": ["The", "C1419385#ent", "<e1>", "activity", "mediated", "cell", "rounding", "and", "loss", "of", "stress", "fibers", "C1424640#ent", "<e2>", "was", "overexpressed", "."], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1424640", "name": "C1424640#ent", "pos": [12, 13]}}
{"token": ["Both", "IFN-beta-", "and", "C1708428#ent", "<e1>", "enhanced", "via", "a", "modulation", "of", "the", "transcriptional", "factor", "IFN-stimulated", "gene", "factors-3", "C1708018#ent", "<e2>", "binding", "to", "respective", "cognate", "regulatory", "elements"], "h": {"id": "C1708428", "name": "C1708428#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1708018", "name": "C1708018#ent", "pos": [16, 17]}}
{"token": ["Study", "of", "the", "pharmacokinetics", "of", "C0043603#ent", "<e1>", "in", "the", "treatment", "of", "C0020437#ent", "<e2>", "show", "this", "drug", "to", "have", "a", "very", "high", "clearance", "due", "to", "calcified", "tissue", "retention", "and", "renal", "excretion"], "h": {"id": "C0043603", "name": "C0043603#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [11, 12]}}
{"token": ["The", "ubiquitin", "conjugating", "E2", ")", "C0014442#ent", "<e1>", "encoded", "by", "C1413263#ent", "<e2>", "(", "UBC3", ")", "in", "Saccharomyces", "cerevisiae", "required", "for", "the", "G1", "to", "S", "transition", "the", "cell", "cycle"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413263", "name": "C1413263#ent", "pos": [9, 10]}}
{"token": ["C3541394#ent", "<e1>", "and", "other", "factors", "secreted", "by", "degranulating", "neutrophils", "C0064833#ent", "<e2>", "PMNs", ")", "mediate", "endothelial", "injury", "thrombosis", ",", "and", "vascular", "remodeling"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [9, 10]}}
{"token": ["Matrix", "metalloproteinases", "MMPs", ")", ",", "the", "key", "C3541394#ent", "<e1>", "responsible", "for", "matrix", "degradation", "are", "derived", "from", "C0064833#ent", "<e2>", "the", "early", "stages", "periodontitis", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [16, 17]}}
{"token": ["We", "evaluated", "the", "individual", "and", "combined", "effects", "of", "an", "inhaled", "beta-adrenergic", "agent", "C0029193#ent", "<e1>", ")", "and", "an", "inhaled", "C3537004#ent", "<e2>", "atropine", ")", "on", "the", "pulmonary", "function", "infants", "with", "bronchopulmonary", "dysplasia"], "h": {"id": "C0029193", "name": "C0029193#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3537004", "name": "C3537004#ent", "pos": [18, 19]}}
{"token": ["C3148863#ent", "<e1>", "and", "exogenous", "C1416991#ent", "<e2>", "increased", "constitutive", "NF-kappa", "B", "activity", "enhanced", "I", "kappa", "B", "kinase", "IKK", ")", "activation", "induced", "by", "CD40", "stimulation", "."], "h": {"id": "C3148863", "name": "C3148863#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1416991", "name": "C1416991#ent", "pos": [4, 5]}}
{"token": ["Prior", "to", "danazol", "treatment", ",", "the", "patient", "had", "a", "7", "year", "history", "of", "C0272282#ent", "<e1>", "refractory", "to", "C3540778#ent", "<e2>", ",", "splenectomy", ",", "azathioprine", ",", "vinca", "alkaloids", "plasma", "infusions", "and", "hormonal", "manipulation", "Premarin-Provera", "."], "h": {"id": "C0272282", "name": "C0272282#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [17, 18]}}
{"token": ["After", "DNA", "damage", ",", "the", "kinase", "ATM", "promoted", "C1416645#ent", "<e1>", "phosphorylation", ",", "leading", "to", "its", "interaction", "with", "the", "isomerase", "C1418582#ent", "<e2>", "and", "its", "degradation", "by", "the", "ubiquitin-proteasome", "system", "."], "h": {"id": "C1416645", "name": "C1416645#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418582", "name": "C1418582#ent", "pos": [19, 20]}}
{"token": ["A", "series", "of", "5", "'", "deletion", "test", "harboring", "promoter", "sequences", "the", "C1415570#ent", "<e1>", "to", "the", "bacterial", "chloramphenicol", "C0001068#ent", "<e2>", "CAT", ")", "gene", "were", "constructed", "."], "h": {"id": "C1415570", "name": "C1415570#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001068", "name": "C0001068#ent", "pos": [17, 18]}}
{"token": ["It", "is", "shown", "that", "C1709289#ent", "<e1>", "is", "preferentially", "associated", "with", "C0008546#ent", "<e2>", "and", "the", "nuclear", "matrix", "interphase", "and", "becomes", "associated", "with", "condensed", "chromatin", "mitosis", "."], "h": {"id": "C1709289", "name": "C1709289#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [10, 11]}}
{"token": ["To", "assess", "the", "correlation", "between", "expression", "of", "C1334508#ent", "<e1>", "early", "apoptotic", "protein", "M30", "(", "M30CytoDEATH", ",", "C3829362#ent", "<e2>", ")", "and", "biologic", "characteristics", "endometrial", "carcinoma"], "h": {"id": "C1334508", "name": "C1334508#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3829362", "name": "C3829362#ent", "pos": [16, 17]}}
{"token": ["In", "adulthood", ",", "Ireb2(-/-", ")", "mice", "develop", "a", "C0026650#ent", "<e1>", "characterized", "by", "C0004134#ent", "<e2>", ",", "bradykinesia", "and", "tremor", "."], "h": {"id": "C0026650", "name": "C0026650#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [12, 13]}}
{"token": ["Two", "days", "later", "hallucinations", ",", "formication", "and", "a", "C0026650#ent", "<e1>", "characterized", "by", "action", "tremor", "myoclonus", ",", "chorea", "and", "C0004134#ent", "<e2>", "."], "h": {"id": "C0026650", "name": "C0026650#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [18, 19]}}
{"token": ["By", "use", "of", "C0028928#ent", "<e1>", "[U-14C]glucose", ",", "esterification", "via", "both", "C0031607#ent", "<e2>", "monoglyceride", "pathways", "quantified", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031607", "name": "C0031607#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "ethanol", "markedly", "stimulated", "C0028928#ent", "<e1>", "incorporation", "in", "C0031607#ent", "<e2>", "PA", ")", ",", "diacylglycerol", "(", "DG", ")", "and", ",", "to", "a", "lesser", "extent", "in", "triacylglycerol", "(", "TG", ")", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031607", "name": "C0031607#ent", "pos": [10, 11]}}
{"token": ["In", "the", "presence", "of", "1", "mm-NaF", ",", "noradrenaline", "stimulated", "the", "incorporation", "of", "C0028928#ent", "<e1>", "into", "the", "choline", "glycerophospholipids", "phosphatidylinositol", ",", "ethanolamine", "glycerophospholipids", "phosphatidylserine", "and", "C0031607#ent", "<e2>", "synaptic", "membranes", "incubated", "in", "10", "mm-Tris-HCl", "buffer", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031607", "name": "C0031607#ent", "pos": [24, 25]}}
{"token": ["The", "DNA", "sequence", "a", "C0769218#ent", "<e1>", "similar", "to", "the", "C1335528#ent", "<e2>", "Escherichia", "coli", "was", "cloned", "from", "the", "Arabidopsis", "genome", "."], "h": {"id": "C0769218", "name": "C0769218#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335528", "name": "C1335528#ent", "pos": [9, 10]}}
{"token": ["Reporter", "gene", "assays", "revealed", "that", "the", "transcriptional", "activity", "the", "C1567710#ent", "<e1>", "promoter", "is", "4", "-", "5-fold", "greater", "in", "C1567710#ent", "<e1>", "knockout", "cells", "than", "in", "C1883559#ent", "<e1>", "fibroblasts", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [24, 25]}}
{"token": ["In", "normal", "prostate", ",", "C0064294#ent", "<e1>", "KGF", ")", ",", "also", "known", "as", "fibroblast", "growth", "factor-7", "C0677829#ent", "<e2>", ")", "serves", "as", "a", "paracrine", "growth", "factor", "in", "stromal", "cells", "acts", "on", "epithelial", "cells", "its", "receptor", ",", "KGFR", "."], "h": {"id": "C0064294", "name": "C0064294#ent", "pos": [4, 5]}, "relation": "chemical_structure_of", "t": {"id": "C0677829", "name": "C0677829#ent", "pos": [15, 16]}}
{"token": ["C0064294#ent", "<e1>", "KGF", ")", "is", "a", "member", "of", "the", "heparin-binding", "fibroblast", "growth", "factor", "family", "C0677829#ent", "<e2>", ")", "with", "a", "distinctive", "pattern", "of", "target-cell", "specificity", "."], "h": {"id": "C0064294", "name": "C0064294#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C0677829", "name": "C0677829#ent", "pos": [14, 15]}}
{"token": ["However", ",", "epithelium", "removal", "and", "C0070915#ent", "<e1>", "did", "not", "increase", "the", "weak", "responses", "to", "the", "C1412716#ent", "<e2>", "and", "NK-3", "selective", "compounds", "."], "h": {"id": "C0070915", "name": "C0070915#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412716", "name": "C1412716#ent", "pos": [15, 16]}}
{"token": ["The", "breakdown", "of", "symptoms", "were", "9", "cases", "of", "acute", "pharyngitis", "5", "cases", "of", "acute", "tonsillitis", "3", "cases", "of", "C0149514#ent", "<e1>", "and", "1", "case", "each", "of", "impetigo", "+", "purulent", "rhinitis", "cervical", "lymphadenitis", "C0036285#ent", "<e2>", "and", "urinary", "tract", "infection"], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0036285", "name": "C0036285#ent", "pos": [31, 32]}}
{"token": ["These", "patients", "included", "10", "with", "acute", "tonsillitis", "6", "with", "C0149514#ent", "<e1>", "5", "with", "bronchopneumonia", ",", "2", "with", "C0036285#ent", "<e2>", "2", "with", "urinary", "tract", "infections", "and", "one", "each", "with", "acute", "pneumonia", "acute", "otitis", "media", "acute", "otitis", "plus", "sweat", "gland", "abscess", "staphylococcal", "scalded", "skin", "syndrome", "acute", "lymphadenitis"], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036285", "name": "C0036285#ent", "pos": [17, 18]}}
{"token": ["Indications", "were", ":", "tonsillitis", ",", "C0149514#ent", "<e1>", ",", "otitis", "media", "sinusitis", "and", "C0036285#ent", "<e2>"], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036285", "name": "C0036285#ent", "pos": [12, 13]}}
{"token": ["Male", "sex", "hypertension", ",", "impaired", "plasma", "creatinine", "creatinine", "clearance", "in", "patients", "from", "these", "two", "groups", "were", "associated", "with", "progression", "to", "C0022661#ent", "<e1>", "death", "from", "C0041948#ent", "<e2>", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [24, 25]}}
{"token": ["Ventricular", "myosin", "C0040127#ent", "<e1>", "rabbits", "has", "higher", "C1413043#ent", "<e2>", "+", "-ATPase", "activity", "compared", "with", "euthyroid", "rabbits", ",", "the", "hyperthropied", "atria", "however", ",", "show", "no", "change", "in", "myosin", "ATPase", "thyroxine", "administration", "."], "h": {"id": "C0040127", "name": "C0040127#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [7, 8]}}
{"token": ["C0050537#ent", "<e1>", "ASA", ")", ",", "acetazolamide", ",", "diazoxide", ",", "phenylbutazone", ",", "C0038745#ent", "<e2>", "(", "S", ")", ",", "and", "tolbutamide", "(", "T", ")", "decreased", "F", "binding"], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038745", "name": "C0038745#ent", "pos": [11, 12]}}
{"token": ["It", "is", "likely", "that", "the", "greater", "effectiveness", "of", "alpha", "C0039902#ent", "<e1>", "relative", "to", "C0046319#ent", "<e2>", "is", "due", "to", "differences", "in", "the", "chemical", "structure", "these", "two", "thiol", "compounds"], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0046319", "name": "C0046319#ent", "pos": [13, 14]}}
{"token": ["This", "protein", ",", "named", "the", "ficolin-like", "protein", "was", "shown", "to", "be", "sensitive", "to", "C0962754#ent", "<e1>", "and", "similar", "to", "C1334101#ent", "<e2>", "in", "that", "it", "was", "also", "disulphide-linked", "into", "an", "oligomer", "of", "approx", "."], "h": {"id": "C0962754", "name": "C0962754#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334101", "name": "C1334101#ent", "pos": [18, 19]}}
{"token": ["C1425945#ent", "<e1>", "was", "capable", "of", "autophosphorylation", "and", "specific", "serine", "phosphorylation", "C1705526#ent", "<e2>", "."], "h": {"id": "C1425945", "name": "C1425945#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [10, 11]}}
{"token": ["The", "recommended", "dosage", "of", "C0075632#ent", "<e1>", "at", "the", "onset", "of", "C0149931#ent", "<e2>", "symptoms", "is", "100", "mg", "orally", "or", "6", "mg", "subcutaneously", "."], "h": {"id": "C0075632", "name": "C0075632#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [10, 11]}}
{"token": ["C0024353#ent", "<e1>", "LPAAT", ")", "is", "a", "pivotal", "C0014442#ent", "<e2>", "controlling", "the", "metabolic", "flow", "lysophosphatidic", "acid", "different", "phosphatidic", "acids", "diverse", "tissues", "."], "h": {"id": "C0024353", "name": "C0024353#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["C0024353#ent", "<e1>", "LPAT", ")", "is", "a", "pivotal", "C0014442#ent", "<e2>", "controlling", "the", "metabolic", "flow", "lysophosphatidic", "acid", "different", "phosphatidic", "acids", "diverse", "tissues", "."], "h": {"id": "C0024353", "name": "C0024353#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["The", "number", "of", "satellites", ",", "number", "of", "C1136365#ent", "<e1>", "amplitude", "were", "also", "significantly", "increased", "in", "the", "C1456383#ent", "<e2>", "group", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1456383", "name": "C1456383#ent", "pos": [16, 17]}}
{"token": ["According", "to", "the", "American", "Association", "of", "Control", "Centers", ",", "the", "most", "commonly", "used", "antidotes", "are", "C0001047#ent", "<e1>", ",", "naloxone", ",", "atropine", ",", "deferoxamine", "(", "C3253705#ent", "<e2>", ")", "and", "antivenins", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3253705", "name": "C3253705#ent", "pos": [24, 25]}}
{"token": ["Peroxynitrite-dependent", "nitrations", "were", "impaired", "when", "synaptosomes", "were", "pretreated", "with", "thioreductants", "(", "glutathione", ",", "C0001047#ent", "<e1>", "dithiothreitol", ")", "or", "antioxidants", "(", "uric", "acid", "melatonin", ",", "bovine", "serum", "albumin", "C3253705#ent", "<e2>", ")", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3253705", "name": "C3253705#ent", "pos": [27, 28]}}
{"token": ["Because", "of", "the", "loss", "of", "C0008732#ent", "<e1>", "the", "gut", "lumen", "protein-losing", "enteropathy", "results", "as", "well", "as", "lymphopenia", "and", "C2936664#ent", "<e2>", "."], "h": {"id": "C0008732", "name": "C0008732#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936664", "name": "C2936664#ent", "pos": [18, 19]}}
{"token": ["Immunoprecipitation", "analysis", "that", "TDFLT3", "but", "not", "C1333568#ent", "<e1>", "formed", "a", "complex", "with", "C3273507#ent", "<e2>", ",", "and", "that", "the", "HA", "treatment", "dissociated", "TDFLT3", "from", "the", "C3273507#ent", "<e2>", "chaperone", "complex"], "h": {"id": "C1333568", "name": "C1333568#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [12, 13]}}
{"token": ["C0033228#ent", "<e1>", "plasma", "lipids", "lipoproteins", "was", "studied", "in", "23", "patients", "with", "C0020476#ent", "<e2>", "HLP", ")", ":", "12", "with", "familial", "hypercholesterolemia", "FH", ")", ",", "5", "with", "combined", "HLP", "and", "6", "with", "Type", "III", "HLP", "."], "h": {"id": "C0033228", "name": "C0033228#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [11, 12]}}
{"token": ["Overall", ",", "C0033228#ent", "<e1>", "was", "found", "to", "be", "effective", "in", "patients", "with", "type", "IV", "C0020476#ent", "<e2>", "and", "caused", "no", "clinically", "significant", "adverse", "effects", "would", "preclude", "its", "use", "in", "these", "patients", "."], "h": {"id": "C0033228", "name": "C0033228#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [14, 15]}}
{"token": ["Low", "concentrations", "of", "serine", "esterase", "inhibitors", "inhibited", "C0054741#ent", "<e1>", "and", "acyl-CoA", "hydrolase", "activities", "but", "stimulated", "C1258847#ent", "<e2>", "activity", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [15, 16]}}
{"token": ["C0054741#ent", "<e1>", "to", "control", "levels", "48", "h", ",", "whereas", "C1258847#ent", "<e2>", "activity", "was", "not", "inhibited", "following", "the", "initial", "soman", "exposure", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [9, 10]}}
{"token": ["Within", "the", "C0005064#ent", "<e1>", ",", "lorazepam", "seems", "to", "have", "advantages", "over", "C0012010#ent", "<e2>", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [2, 3]}, "relation": "structural_class_of", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [11, 12]}}
{"token": ["Molecular", "cloning", "characterization", "of", "the", "wild-type", "allele", "of", "the", "mutated", "gene", "that", "it", "(", "C3538851#ent", "<e1>", ")", "encodes", "a", "previously", "characterized", "C1514208#ent", "<e2>", "unknown", "RNA", "substrate", "specificity", "."], "h": {"id": "C3538851", "name": "C3538851#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1514208", "name": "C1514208#ent", "pos": [21, 22]}}
{"token": ["This", "C0211705#ent", "<e1>", "brings", "about", "mitosis-specific", "cytoskeletal", "rearrangements", ",", "C1826786#ent", "<e2>", "and", "nuclear", "envelope", "breakdown", "inducing", "a", "mitosis-like", "state", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1826786", "name": "C1826786#ent", "pos": [9, 10]}}
{"token": ["We", "also", "present", "evidence", "that", "the", "nucleosomes", ",", "through", "physical", "association", "were", "able", "to", "deplete", "the", "extracts", "from", "the", "kinase", "phosphorylating", "histone", "H3", "Ser10", ",", "suggesting", "that", "this", "C0211705#ent", "<e1>", "could", "be", "important", "for", "C1826786#ent", "<e2>"], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1826786", "name": "C1826786#ent", "pos": [34, 35]}}
{"token": ["The", "index", "case", "a", "woman", "with", "a", "lifelong", "history", "of", "bleeding", ",", "found", "C0085129#ent", "<e1>", "to", "ristocetin", "with", "spontaneous", "platelet", "aggregation", "(", "C1420002#ent", "<e2>", ")", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [22, 23]}}
{"token": ["A", "patient", "with", "the", "C0237974#ent", "<e1>", "AIDS", ")", "and", "the", "C0497156#ent", "<e2>", "variant", "of", "Kaposi's", "sarcoma", "skin", ",", "gastrointestinal", "and", "pulmonary", "lesions"], "h": {"id": "C0237974", "name": "C0237974#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0497156", "name": "C0497156#ent", "pos": [10, 11]}}
{"token": ["The", "relationship", "between", "pulmonary", "hypertension", "lesions", "was", "examined", "in", "41", "dogs", "infested", "naturally", "with", "heartworms", ",", "which", "consisted", "of", "28", "cases", "with", "C0012602#ent", "<e1>", "13", "cases", "with", "C0038833#ent", "<e2>"], "h": {"id": "C0012602", "name": "C0012602#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038833", "name": "C0038833#ent", "pos": [27, 28]}}
{"token": ["Nevertheless", ",", "inhaled", "pentamidine", "seem", "poised", "to", "become", "routine", "prophylaxis", "in", "patients", "with", "AIDS", "or", "C0001849#ent", "<e1>", "risk", "of", "developing", "C1422070#ent", "<e2>", "."], "h": {"id": "C0001849", "name": "C0001849#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [20, 21]}}
{"token": ["In", "this", "study", ",", "3T3", "cell", "detachment", "from", "a", "chemically", "homologous", "of", "copolymers", "based", "on", "hydroxyethylmethacrylate", "(", "C1704822#ent", "<e1>", ")", "and", "ethylmethacrylate", "(", "C1414471#ent", "<e2>", ")", "was", "measured", "with", "a", "spinning-disc", "apparatus", "."], "h": {"id": "C1704822", "name": "C1704822#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414471", "name": "C1414471#ent", "pos": [23, 24]}}
{"token": ["We", "have", "previously", "shown", "that", "the", "related", "EG-VEGF", "and", "Bv8", "proteins", ",", "also", "known", "as", "prokineticin", "1", "Prok1", ")", "and", "C1425527#ent", "<e1>", "Prok2", ")", ",", "promote", "both", "C1420295#ent", "<e2>", "angiogenesis", "and", "haematopoietic", "cell", "mobilization"], "h": {"id": "C1425527", "name": "C1425527#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [27, 28]}}
{"token": ["Both", "physical", "and", "genetic", "mapping", "indicate", "that", "C1420544#ent", "<e1>", "is", "near", "two", "mutant", "loci", "defined", "by", "C0751950#ent", "<e2>", "opisthotonus", "(", "opt", ")", "and", "deaf", "waddler", "(", "dfw", ")", "."], "h": {"id": "C1420544", "name": "C1420544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [16, 17]}}
{"token": ["C0010414#ent", "<e1>", "is", "a", "C0553576#ent", "<e2>", "affecting", "patients", "of", "immunodeficiency", "i.e.", "transplants", "recipients", ",", "patients", "on", "chemotherapy", "for", "neoplastic", "diseases", "in", "those", "suffering", "from", "human", "immunodeficiency", "virus", "infection"], "h": {"id": "C0010414", "name": "C0010414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0553576", "name": "C0553576#ent", "pos": [4, 5]}}
{"token": ["In", "addition", ",", "C0077274#ent", "<e1>", "was", "found", "to", "decrease", "C2936824#ent", "<e2>", "PI3K", "activity", "."], "h": {"id": "C0077274", "name": "C0077274#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [9, 10]}}
{"token": ["We", "found", "that", "both", "Stra13", "and", "C1424440#ent", "<e1>", "inhibit", "SREBP-1c-induced", "transcription", "by", "competing", "with", "C1420398#ent", "<e2>", "for", "binding", "to", "the", "E-box", "in", "the", "C1420398#ent", "<e2>", "promoter", "and/or", "by", "interacting", "with", "SREBP-1c", "protein"], "h": {"id": "C1424440", "name": "C1424440#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420398", "name": "C1420398#ent", "pos": [14, 15]}}
{"token": ["Patients", "who", "survive", "an", "acute", "myocardiac", "infarction", "AMI", ")", "have", "significant", "C1956346#ent", "<e1>", "are", "at", "risk", "for", "C0002962#ent", "<e2>", "recurrent", "myocardiac", "infarction", "sudden", "death"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [17, 18]}}
{"token": ["Of", "12", "patients", "aged", "over", "50", "years", "with", "C1956346#ent", "<e1>", "no", "patient", "was", "C0002962#ent", "<e2>"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [13, 14]}}
{"token": ["A", "long-term", ",", "open", "clinical", "trial", "verapamil", "therapy", "conducted", "in", "93", "patients", "with", "C1956346#ent", "<e1>", "selected", "on", "the", "basis", "of", "having", "stable", "C0002962#ent", "<e2>", "of", "being", "unsuitable", "for", "treatment", "with", "beta-adrenergic", "blocking", "drugs"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [22, 23]}}
{"token": ["Both", "patients", "with", "C1956346#ent", "<e1>", "CAD", ")", "and", "those", "with", "syndrome", "X", "C0002962#ent", "<e2>", "exercise-induced", "myocardial", "ischemia", ",", "normal", "coronary", "angiogram", "no", "evidence", "of", "coronary", "spasm", "have", "ischemic", "electrocardiogram", "ECG", ")", "during", "exercise", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [12, 13]}}
{"token": ["OPGL", "together", "with", "C1524095#ent", "<e1>", "M-CSF", ")", "also", "stimulated", "C1413815#ent", "<e2>", "gene", "expression", "monocytic", "cells", "multinucleate", "osteoclasts", "in", "bone", "marrow", "cultures"], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413815", "name": "C1413815#ent", "pos": [9, 10]}}
{"token": ["OPGL", "together", "with", "macrophage", "colony-stimulating", "factor", "C1524095#ent", "<e1>", ")", "also", "stimulated", "C1413815#ent", "<e2>", "gene", "expression", "monocytic", "cells", "multinucleate", "osteoclasts", "in", "bone", "marrow", "cultures"], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413815", "name": "C1413815#ent", "pos": [11, 12]}}
{"token": ["Cefuroxime", "axetil", "alone", "is", "effective", "for", "C0018081#ent", "<e1>", "males", ";", "rectal", "gonorrhea", "requires", "additional", "C0033209#ent", "<e2>", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [14, 15]}}
{"token": ["Chronic", "C0035179#ent", "<e1>", "administration", "produces", "persistent", "oral", "C0013384#ent", "<e2>", "accompanied", "by", "severe", "dopamine", "depletion", "in", "the", "caudate-putamen", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [7, 8]}}
{"token": ["Rats", "treated", "with", "C0035179#ent", "<e1>", "develop", "spontaneous", "orofacial", "C0013384#ent", "<e2>", "that", "has", "features", "similar", "to", "tardive", "dyskinesia", "TD", ")", "in", "humans", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [8, 9]}}
{"token": ["Surprisingly", ",", "chronic", "administration", "C0035179#ent", "<e1>", "alone", "produced", "a", "spontaneous", "oral", "C0013384#ent", "<e2>", ",", "which", "was", "blocked", "dose-dependently", "by", "the", "D2-selective", "antagonist", "spiroperidol", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [11, 12]}}
{"token": ["Acute", "C0035179#ent", "<e1>", "administration", "produces", "persistent", "C0013384#ent", "<e2>", "rats", ",", "an", "alleged", "animal", "model", "tardive", "dyskinesia"], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [6, 7]}}
{"token": ["C1413746#ent", "<e1>", "was", "found", "to", "associate", "with", "C0108855#ent", "<e2>", "CDK", ")", "4", ",", "and", "reduction", "of", "nuclear", "C1413746#ent", "<e1>", "levels", "resulted", "in", "reduced", "nuclear", "CDK4", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413746", "name": "C1413746#ent", "pos": [0, 1]}}
{"token": ["We", "conclude", "that", "the", "TechLab", "E.", "histolytica", "II", "kit", "is", "a", "sensitive", "means", "to", "diagnose", "hepatic", "and", "C0002438#ent", "<e1>", "to", "the", "institution", "of", "C0025872#ent", "<e2>", "treatment", "."], "h": {"id": "C0002438", "name": "C0002438#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [23, 24]}}
{"token": ["C0002438#ent", "<e1>", "its", "perforation", "became", "the", "most", "likely", "diagnosis", ",", "and", "C0025872#ent", "<e2>", "was", "administered", "."], "h": {"id": "C0002438", "name": "C0002438#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [11, 12]}}
{"token": ["Monospecific", "polyclonal", "antisera", "been", "raised", "to", "purified", "C1453024#ent", "<e1>", "to", "the", "individual", "large", "and", "small", "subunits", "this", "C0027203#ent", "<e2>", "."], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}}
{"token": ["Two", "membrane", "proteins", "NADH", "oxidase", "C1453024#ent", "<e1>", "and", "a", "soluble", "C0027203#ent", "<e2>", "(", "lactoperoxidase", ")", "retained", "full", "activity", "in", "the", "presence", "of", "HECAMEG", "below", "or", "above", "its", "CMC", "."], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["A", "single-blind", "crossover", "trial", "comparing", "beclomethasone", "dipropionate", "inhalation", "with", "C0032950#ent", "<e1>", "by", "mouth", "in", "the", "treatment", "of", "C0004096#ent", "<e2>", "children", "over", "a", "period", "of", "10", "months", "is", "reported", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}}
{"token": ["In", "other", "signaling", "systems", "use", "the", "JAK/STAT", "pathway", ",", "C0086376#ent", "<e1>", "of", "the", "suppressor", "of", "cytokine", "signaling", "C1332762#ent", "<e2>", ")", "family", "participate", "in", "signal", "regulation"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332762", "name": "C1332762#ent", "pos": [17, 18]}}
{"token": ["Cytokine", "responses", "be", "regulated", "by", "a", "family", "of", "C0086376#ent", "<e1>", "termed", "suppressors", "of", "cytokine", "signaling", "C1332762#ent", "<e2>", ")", "which", "can", "inhibit", "the", "JAK/STAT", "pathway", "in", "a", "classical", "negative-feedback", "manner", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332762", "name": "C1332762#ent", "pos": [15, 16]}}
{"token": ["C0085270#ent", "<e1>", "mimic", "angioedema", "or", "C0009766#ent", "<e2>", "should", "be", "familiar", "to", "allergists", "and", "primary", "care", "physicians"], "h": {"id": "C0085270", "name": "C0085270#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [5, 6]}}
{"token": ["We", "gradually", "induced", "a", "selective", "loss", "of", "nigrostriatal", "dopamine", "neurons", ",", "similar", "to", "that", "of", "C1868675#ent", "<e1>", "by", "creating", "oxidative", "stress", "infusion", "of", "the", "C1453024#ent", "<e2>", "inhibitor", "MPTP", "for", "14+/-5", "months", "."], "h": {"id": "C1868675", "name": "C1868675#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1453024", "name": "C1453024#ent", "pos": [24, 25]}}
{"token": ["We", "have", "also", "shown", "that", "hypokalemic", "periodic", "paralysis", "C0238358#ent", "<e1>", ")", "is", "caused", "by", "mutations", "in", "a", "C0017337#ent", "<e2>", "encoding", "a", "voltage-gated", "calcium", "channel"], "h": {"id": "C0238358", "name": "C0238358#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}}
{"token": ["Caution", "must", "be", "exercised", "with", "the", "use", "of", "large", "doses", "C0073631#ent", "<e1>", "especially", "if", "the", "C1254351#ent", "<e2>", "is", "used", "for", "more", "than", "5", "days", "to", "avoid", "serious", "complications", "like", "renal", "failure", "gastrointestinal", "bleeding"], "h": {"id": "C0073631", "name": "C0073631#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["The", "data", "strongly", "suggest", "that", "C0073631#ent", "<e1>", "analgesic", "effect", "on", "the", "blood", "concentration", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C0073631", "name": "C0073631#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["The", "combination", "of", "half-doses", "of", "morphine", "and", "C0073631#ent", "<e1>", "is", "more", "effective", "in", "controlling", "postoperative", "pain", "than", "either", "C1254351#ent", "<e2>", "alone", "."], "h": {"id": "C0073631", "name": "C0073631#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["In", "general", ",", "C0006812#ent", "<e1>", "are", "not", "substrates", "for", "either", "the", "C0596326#ent", "<e2>", "P-glycoprotein", "or", "the", "multidrug-resistance-associated", "protein", "MRP", ")", "."], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0596326", "name": "C0596326#ent", "pos": [11, 12]}}
{"token": ["The", "locus", "encodes", "iron", "sulfur", "protein", "alpha", "beta", "subunits", "a", "C3203102#ent", "<e1>", "initial", "dioxygenase", "but", "lacks", "the", "C1414571#ent", "<e2>", "and", "reductase", "components", "."], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414571", "name": "C1414571#ent", "pos": [17, 18]}}
{"token": ["Variants", "of", "apolipoprotein", "E", "apoE", ")", "have", "been", "linked", "to", "C2673196#ent", "<e1>", "a", "new", "C0268731#ent", "<e2>", "by", "the", "deposition", "of", "lipoproteins", "in", "mesangial", "capillaries"], "h": {"id": "C2673196", "name": "C2673196#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [14, 15]}}
{"token": ["On", "the", "other", "hand", ",", "discovery", "and", "new", "hereditary", "metabolic", "disorders", "such", "as", "type", "III", "hyperlipoproteinemia", "C2673196#ent", "<e1>", "shows", "that", "apolipoprotein", "(apo)", "E", "abnormalities", "responsible", "for", "the", "C0268731#ent", "<e2>"], "h": {"id": "C2673196", "name": "C2673196#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [27, 28]}}
{"token": ["Although", "C0007248#ent", "<e1>", "is", "a", "relatively", "inexpensive", "C0040616#ent", "<e2>", "its", "questionable", "efficacy", "and", "the", "potential", "for", "life-threatening", "intoxication", "are", "important", "drawbacks", "to", "the", "clinical", "use", "this", "drug", "."], "h": {"id": "C0007248", "name": "C0007248#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0040616", "name": "C0040616#ent", "pos": [7, 8]}}
{"token": ["Separation", "of", "sarcoplasmic", "proteins", "by", "fractionation", "on", "Sephadex", "and", "C0046079#ent", "<e1>", "cellulose", "columns", "indicated", "that", "a", "low", "abundance", "C0684153#ent", "<e2>", "in", "bovine", "l.", "dorsi", "muscle", "."], "h": {"id": "C0046079", "name": "C0046079#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0684153", "name": "C0684153#ent", "pos": [18, 19]}}
{"token": ["In", "this", "double-blind", ",", "multicentre", "study", "antihistamine", "C0054340#ent", "<e1>", "was", "compared", "with", "terfenadine", "for", "the", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C0054340", "name": "C0054340#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [17, 18]}}
{"token": ["Both", "4", "mg", "and", "8", "mg", "C0054340#ent", "<e1>", "alleviated", "the", "symptoms", "of", "C0035457#ent", "<e2>", "significant", "improvements", "in", "the", "symptom", "scores", "for", "sneezing", ",", "running", "nose", "the", "calculated", "overall", "score", "."], "h": {"id": "C0054340", "name": "C0054340#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [12, 13]}}
{"token": ["In", "the", "brain", ",", "the", "organellar-type", "Ca2", "+", "transport", "C0001473#ent", "<e1>", "are", "almost", "exclusively", "transcribed", "from", "the", "C1567357#ent", "<e2>", "gene", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [9, 10]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1567357", "name": "C1567357#ent", "pos": [17, 18]}}
{"token": ["CDC25B2", ",", "a", "C1335554#ent", "<e1>", "related", "to", "the", "putative", "C1563402#ent", "<e2>", "oncogene", ",", "was", "identified", "in", "a", "Burkitt", "lymphoma", "library", "."], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1563402", "name": "C1563402#ent", "pos": [9, 10]}}
{"token": ["PGF2alpha", "enhanced", "the", "phosphorylation", "of", "the", "epidermal", "growth", "factor", "EGF", ")", "receptor", ",", "and", "a", "selective", "inhibitor", "of", "EGF", "receptor", "kinase", "C0213654#ent", "<e1>", "AG1478", ",", "significantly", "suppressed", "PGF2alpha-induced", "C1456389#ent", "<e2>", "expression", "."], "h": {"id": "C0213654", "name": "C0213654#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1456389", "name": "C1456389#ent", "pos": [28, 29]}}
{"token": ["Despite", "this", ",", "it", "completely", "suppresses", "C1415876#ent", "<e1>", "by", "sustaining", "C1370600#ent", "<e2>", "activation", "and", "inhibiting", "caspase", "8", "activation", "in", "phagocytosing", "neutrophils", "."], "h": {"id": "C1415876", "name": "C1415876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [10, 11]}}
{"token": ["A", "neural", "plakophilin-related", "armadillo", "repeat", "protein", "interacts", "with", "one", "of", "C0002395#ent", "<e1>", "disease-related", "gene", "products", ",", "C1418985#ent", "<e2>"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [10, 11]}, "relation": "disease_has_associated_gene", "t": {"id": "C1418985", "name": "C1418985#ent", "pos": [16, 17]}}
{"token": ["Many", "cases", "of", "early-onset", "C0002395#ent", "<e1>", "FAD", ")", "are", "caused", "by", "mutations", "in", "the", "C1418985#ent", "<e2>", "PS1", ")", "and", "PS2", "genes"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1418985", "name": "C1418985#ent", "pos": [14, 15]}}
{"token": ["Most", "cases", "of", "early", "onset", "C0002395#ent", "<e1>", "FAD", ")", "involve", "mutations", "in", "presenilins", "(", "C1418985#ent", "<e2>", "and", "PS2", ")", "genes", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1418985", "name": "C1418985#ent", "pos": [14, 15]}}
{"token": ["These", "results", "indicate", "that", "C0031667#ent", "<e1>", "activation", "may", "play", "a", "role", "in", "the", "induction", "of", "C0304402#ent", "<e2>", "sensitization", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "the", "SV40-induced", "signalling", "pathway", "includes", "the", "activities", "of", "a", "tyrosine", "kinase", "a", "Ca(2+)-independent", "C0597298#ent", "<e1>", "of", "PKC", ",", "but", "not", "of", "C1425569#ent", "<e2>", "or", "MAP", "kinase"], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [25, 26]}}
{"token": ["Increases", "in", "endogenous", "levels", "of", "cAMP", "induced", "by", "the", "phosphodiesterase", "inhibitor", "C0128513#ent", "<e1>", "mirrored", "the", "actions", "of", "C0079594#ent", "<e2>", ",", "suggesting", "that", "the", "prostacyclin", "analog", "its", "actions", "via", "cAMP", "activation", "."], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079594", "name": "C0079594#ent", "pos": [17, 18]}}
{"token": ["In", "dose-effect", "curve", "experiments", "the", "AHS", "induced", "by", "naloxone", "or", "C0027355#ent", "<e1>", "was", "significantly", "reduced", "by", "previous", "injections", "of", "scopolamine", ",", "C0037956#ent", "<e2>", ",", "metergoline", "or", "phentolamine", "in", "the", "corresponding", "groups", "."], "h": {"id": "C0027355", "name": "C0027355#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037956", "name": "C0037956#ent", "pos": [21, 22]}}
{"token": ["To", "examine", "the", "effects", "of", "C0003015#ent", "<e1>", "pepstatin-A", ",", "a", "long", "acting", "H2-receptor", "blocker", ",", "C0065201#ent", "<e2>", ",", "exogenous", "pepsin", "and", "exogenous", "acid", "against", "indomethacin-induced", "antral", "ulceration", "in", "the", "rat", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0065201", "name": "C0065201#ent", "pos": [15, 16]}}
{"token": ["C0028066#ent", "<e1>", "has", "been", "used", "to", "treat", "C0235222#ent", "<e2>", "in", "many", "cases", "it", "has", "proved", "superior", "to", "other", "antihypertensive", "drugs"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235222", "name": "C0235222#ent", "pos": [7, 8]}}
{"token": ["The", "cost-effectiveness", "of", "C0028066#ent", "<e1>", "for", "the", "control", "of", "C0235222#ent", "<e2>", "analyzed", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235222", "name": "C0235222#ent", "pos": [9, 10]}}
{"token": ["In", "certain", "postembryonic", "cell", "lineages", ",", "various", "aspects", "of", "the", "C0080054#ent", "<e1>", "including", "cell", "cycle", "exit", "or", "G1/S", "progression", ",", "are", "controlled", "by", "C0017362#ent", "<e2>", "the", "heterochronic", "gene", "pathway", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0017362", "name": "C0017362#ent", "pos": [23, 24]}}
{"token": ["The", "inhibition", "of", "the", "C0597979#ent", "<e1>", "of", "E.", "coli", "by", "C1412820#ent", "<e2>", "1437", "was", "shown", "to", "be", "reversible", "and", "competitive", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412820", "name": "C1412820#ent", "pos": [10, 11]}}
{"token": ["All", "the", "C0597979#ent", "<e1>", "were", "rapidly", "inactivated", "by", "C1412820#ent", "<e2>", "42715", ",", "with", "second-order", "rate", "constants", "ranging", "from", "0.17", "to", "6.4", "microM-1.s-1", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412820", "name": "C1412820#ent", "pos": [8, 9]}}
{"token": ["These", "results", "indicate", "that", "C0059239#ent", "<e1>", "might", "play", "a", "role", "in", "a", "signal", "transduction", "system", "C3273436#ent", "<e2>", "in", "glomerular", "mesangial", "cells", "that", "the", "ET-1-induced", "tyrosine", "phosphorylation", "C0059239#ent", "<e1>", "is", "largely", "dependent", "on", "the", "PKC", "pathway", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [15, 16]}}
{"token": ["C0041038#ent", "<e1>", "(", "TMO", ")", ",", "an", "C0003299#ent", "<e2>", "may", "be", "used", "as", "a", "candidate", "for", "estimating", "hepatic", "drug-oxidizing", "activity", "."], "h": {"id": "C0041038", "name": "C0041038#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "we", "could", "show", "an", "induction", "of", "ischemic", "tolerance", "prestroke", "C0007804#ent", "<e1>", "treatment", "in", "patients", "without", "previous", "new-onset", "C0007787#ent", "<e2>", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [20, 21]}}
{"token": ["Clinical", "manifestation", "this", "abnormality", "remains", "unclear", ":", "some", "authors", "have", "suggested", "an", "association", "between", "C0007804#ent", "<e1>", "and", "arrhythmias", "or", "between", "C0007804#ent", "<e1>", "and", "C0007787#ent", "<e1>"], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [23, 24]}}
{"token": ["This", "genome", "contained", "the", "identical", "gene", "organization", "contents", "to", "that", "of", "other", "avian", "blood", "protozoa", "analyzed", ":", "three", "functional", "genes", "cytochrome", "c", "oxidase", "subunit", "I", "III", ",", "and", "C0010744#ent", "<e1>", "following", "sets", "of", "discontinuous", "and", "scrambled", "15", "C0035899#ent", "<e2>"], "h": {"id": "C0010744", "name": "C0010744#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0035899", "name": "C0035899#ent", "pos": [37, 38]}}
{"token": ["We", "demonstrate", "that", "ectopic", "expression", "of", "SF2/ASF", "regulates", "the", "splicing", "and", "polysome", "association", "of", "transcripts", "derived", "from", "the", "SFRS1", ",", "PABC1", ",", "C1413149#ent", "<e1>", "and", "ENSA", "C0017337#ent", "<e2>", "."], "h": {"id": "C1413149", "name": "C1413149#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [26, 27]}}
{"token": ["Knockdown", "of", "C1413149#ent", "<e1>", "expression", "promotes", "megakaryocyte", "differentiation", "and", "enhances", "expression", "of", "select", "C0017337#ent", "<e2>", "expressed", "in", "terminal", "megakaryocyte", "maturation", ",", "eg", ",", "platelet", "factor", "4", "Pf4", ")", "."], "h": {"id": "C1413149", "name": "C1413149#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["Our", "experiments", "with", "ethylene", "over-production", "mutants", "(", "eto1", ",", "C1413149#ent", "<e1>", "and", "eto3", ")", "indicate", "that", "the", "ethylene", "biosynthesis", "C0017337#ent", "<e2>", ",", "ETO1", ",", "can", "act", "as", "an", "inhibitor", "of", "shoot", "regeneration", "."], "h": {"id": "C1413149", "name": "C1413149#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["Eosinophilic", "C0034049#ent", "<e1>", "be", "a", "C0038317#ent", "<e2>", "responsive", "complication", "of", "crack", "cocaine", "abuse"], "h": {"id": "C0034049", "name": "C0034049#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [5, 6]}}
{"token": ["Additional", "data", "were", "gathered", "using", "the", "Acute", "Physiology", "Chronic", "Health", "Evaluation", "II", "and", "details", "on", "smoking", ",", "alcoholism", ",", "diabetes", "mellitus", "renal", "failure", "previous", "C0034049#ent", "<e1>", "and", "previous", "use", "of", "antibiotics", ",", "C0038317#ent", "<e2>", ",", "H2", "antagonists", "antacids", "."], "h": {"id": "C0034049", "name": "C0034049#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [32, 33]}}
{"token": ["C0034049#ent", "<e1>", "to", "be", "C0038317#ent", "<e2>", "responsive", "."], "h": {"id": "C0034049", "name": "C0034049#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [4, 5]}}
{"token": ["C0033497#ent", "<e1>", ",", "a", "beta-adrenergic", "receptor", "antagonist", "blocked", "proliferation", "in", "all", "cases", "except", "C1367721#ent", "<e2>", "treatment", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [13, 14]}}
{"token": ["C0036262#ent", "<e1>", "these", "individual", "requires", "a", "combination", "of", "C0022322#ent", "<e2>", "total", "body", "treatments", "5", "%", "permethrin", "cream", "and", "keratolytic", "agents", "hasten", "removal", "of", "crusts", "."], "h": {"id": "C0036262", "name": "C0036262#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0022322", "name": "C0022322#ent", "pos": [8, 9]}}
{"token": ["Based", "on", "these", "results", ",", "we", "conclude", "that", "C0673815#ent", "<e1>", "may", "represent", "a", "safer", "alternative", "to", "standard", "C0003211#ent", "<e2>", "in", "the", "treatment", "of", "inflammatory", "conditions", "hypertensive", "patients", "."], "h": {"id": "C0673815", "name": "C0673815#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "the", "concomitant", "administration", "of", "MLT", "significantly", "reduced", "the", "frequency", "of", "C0040034#ent", "<e1>", ",", "neurotoxicity", ",", "cardiotoxicity", ",", "stomatitis", "and", "C3714552#ent", "<e2>", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [21, 22]}}
{"token": ["The", "most", "common", "adverse", "events", "associated", "with", "oral", "tegafur/uracil", "anaemia", ",", "nausea/vomiting", ",", "diarrhoea", ",", "C0040034#ent", "<e1>", ",", "mucositis", ",", "neutropenia", ",", "C3714552#ent", "<e2>", ",", "anorexia", "and", "abdominal", "pain"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [22, 23]}}
{"token": ["Together", "our", "data", "cast", "considerable", "doubt", "on", "the", "hypothesis", "that", "there", "is", "a", "direct", "link", "between", "C0379528#ent", "<e1>", "the", "content", "of", "intracellular", "C0001477#ent", "<e2>", "stores", "."], "h": {"id": "C0379528", "name": "C0379528#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [22, 23]}}
{"token": ["Currently", ",", "DNA", "vaccination", "such", "important", "C0030499#ent", "<e1>", "malaria", ",", "leishmaniosis", ",", "toxoplasmosis", ",", "C0010418#ent", "<e2>", ",", "schistosomosis", ",", "fasciolosis", "offers", "several", "new", "opportunities", "."], "h": {"id": "C0030499", "name": "C0030499#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0010418", "name": "C0010418#ent", "pos": [14, 15]}}
{"token": ["The", "C1420232#ent", "<e1>", "of", "5-(N", ",", "N'-dimethyl)-amiloride", "inhibited", "the", "dexamethasone-induced", "increase", "in", "C2975867#ent", "<e2>", "and", "apoptosis", "of", "thymocytes", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2975867", "name": "C2975867#ent", "pos": [12, 13]}}
{"token": ["Amiloride", "and", "4,4'-diisothiocyanostilbene", "2,2-disulfonic", "acid", ",", "inhibitors", "of", "the", "C1420232#ent", "<e1>", "and", "HCO3-/Cl-", "exchangers", "respectively", ",", "decreased", "C2975867#ent", "<e2>", "in", "the", "presence", "of", "nigericin", "at", "low", "pHe"], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2975867", "name": "C2975867#ent", "pos": [17, 18]}}
{"token": ["In", "lymphocytes", ",", "the", "C1420232#ent", "<e1>", "antiport", "is", "well", "suited", "to", "function", "in", "cytoplasmic", "pH", "C2975867#ent", "<e2>", ")", "regulation", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2975867", "name": "C2975867#ent", "pos": [15, 16]}}
{"token": ["Both", "selective", "C4084873#ent", "<e1>", "and", "MAO-B", "inhibitors", "potentiated", "nictitating", "membrane", "contractions", "in", "response", "to", "C0070559#ent", "<e2>", "(", "PEA", ")", "."], "h": {"id": "C4084873", "name": "C4084873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0070559", "name": "C0070559#ent", "pos": [14, 15]}}
{"token": ["Molecular", "weights", "C1414426#ent", "<e1>", "in", "the", "C0155365#ent", "<e2>", "aqueous", "humor", "were", "approximately", "66", "and", "110", "kilodaltons", "(", "kDa", ")", ",", "respectively", ",", "as", "determined", "by", "fibrinolysis", "enzymography", "."], "h": {"id": "C1414426", "name": "C1414426#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0155365", "name": "C0155365#ent", "pos": [6, 7]}}
{"token": ["Like", "other", "TLR", "family", "members", "constitutively", "active", "C1336638#ent", "<e1>", "activates", "both", "NF-kappaB", "and", "C0248813#ent", "<e2>", "JNK", ")", "."], "h": {"id": "C1336638", "name": "C1336638#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [13, 14]}}
{"token": ["The", "major", "clinical", "features", "are", "hepatopathy", ",", "peripheral", "neuropathy", "C0271291#ent", "<e1>", "scarring", ",", "acral", "mutilation", ",", "C0270612#ent", "<e2>", "failure", "to", "thrive", ",", "and", "recurrent", "metabolic", "acidosis", "intercurrent", "infections"], "h": {"id": "C0271291", "name": "C0271291#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0270612", "name": "C0270612#ent", "pos": [16, 17]}}
{"token": ["Tissue", "inhibitors", "C1334706#ent", "<e1>", "(", "TIMPs", ")", "inhibit", "C0623362#ent", "<e2>", "MMPs", ")", "by", "forming", "a", "1:1", "stoichiometric", "complex", "but", "the", "inhibition", "mechanism", "of", "these", "inhibitors", "is", "not", "known", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [8, 9]}}
{"token": ["Liver", "expression", "some", "C1334706#ent", "<e1>", "(", "C0623362#ent", "<e2>", ")", "and", "of", "tissue", "inhibitors", "C0623362#ent", "<e2>", "(", "TIMPs", ")", "also", "indicated", "decreased", "collagen", "breakdown", "in", "cirrhotic", "livers", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [6, 7]}}
{"token": ["Circumstantial", "evidence", "indicates", "that", "the", "effect", "of", "circulatory", "iron", "C1423607#ent", "<e1>", "requires", "functional", "HFE", "and", "C3810562#ent", "<e2>", ",", "two", "proteins", "of", "unknown", "function", "that", "have", "recently", "been", "linked", "to", "human", "hereditary", "hemochromatosis"], "h": {"id": "C1423607", "name": "C1423607#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3810562", "name": "C3810562#ent", "pos": [15, 16]}}
{"token": ["C1262117#ent", "<e1>", "a", "devastating", "C0015403#ent", "<e2>", "after", "eye", "injury"], "h": {"id": "C1262117", "name": "C1262117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015403", "name": "C0015403#ent", "pos": [4, 5]}}
{"token": ["We", "show", "that", "the", "C0014442#ent", "<e1>", "binds", "essentially", "as", "a", "C0026837#ent", "<e2>", "and", "that", "one", "end", "of", "the", "DNA", "is", "accommodated", "loosely", "in", "the", "binding", "cleft", "the", "other", "end", "is", "held", "tightly", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [10, 11]}}
{"token": ["Microstructural", "observations", "and", "measurement", "of", "sarcomere", "length", "by", "laser", "diffraction", "transmission", "and", "scanning", "electron", "microscopy", "indicated", "that", "C0014442#ent", "<e1>", "treatment", "hastened", "the", "change", "from", "C0026837#ent", "<e2>", "to", "aged", "muscle", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [24, 25]}}
{"token": ["CFS", "is", "characterized", "by", "debilitating", "fatigue", "with", "associated", "C0231528#ent", "<e1>", ",", "tender", "lymph", "nodes", "arthralgias", ",", "chills", ",", "C0015967#ent", "<e2>", "feelings", ",", "and", "postexertional", "malaise", "."], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [18, 19]}}
{"token": ["We", "compared", "the", "C1413766#ent", "<e1>", "titers", "in", "mumps", "patients", "with", "C0029191#ent", "<e2>", "and", "meningitis", "."], "h": {"id": "C1413766", "name": "C1413766#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029191", "name": "C0029191#ent", "pos": [10, 11]}}
{"token": ["High-performance", "liquid", "chromatographic", "determinations", "gabexate", "mesilate", "FOY", ")", ",", "prostaglandin", "E1", "PGE1", ")", ",", "C0164190#ent", "<e1>", "(", "PGE1-CD", ")", ",", "prednisolone", "(", "PD", ")", "and", "C0625740#ent", "<e2>", "BF", ")", "incorporated", "in", "gel", "ointment", "investigated", "."], "h": {"id": "C0164190", "name": "C0164190#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0625740", "name": "C0625740#ent", "pos": [25, 26]}}
{"token": ["They", "are", "unique", "among", "invasive", "C0037974#ent", "<e1>", "in", "that", "they", "contain", "outer", "membrane", "lipopolysaccharide", "C2697656#ent", "<e2>", ")", "as", "well", "as", "lipoproteins", "."], "h": {"id": "C0037974", "name": "C0037974#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [14, 15]}}
{"token": ["A", "theoretical", "approach", "the", "description", "of", "the", "deformation", "of", "the", "C0017343#ent", "<e1>", "of", "a", "spherical", "C0085423#ent", "<e2>", "presented", "."], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [15, 16]}}
{"token": ["It", "has", "also", "been", "shown", "that", "C0082529#ent", "<e1>", "regulate", "cocaine-induced", "expression", "of", "c-Fos", "and", "C1705124#ent", "<e2>", ",", "two", "possible", "components", "of", "activator", "protein", "1"], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705124", "name": "C1705124#ent", "pos": [14, 15]}}
{"token": ["A", "case", "of", "acute", "methylmercury", "ingestion", "was", "treated", "sequentially", "with", "oral", "D-penicillamine", "hemodialysis", "during", "N-acetylcysteine", "(", "C1622105#ent", "<e1>", ")", "infusion", ",", "and", "C0012383#ent", "<e2>", "DMPS", ")", "an", "experimental", "oral", "agent"], "h": {"id": "C1622105", "name": "C1622105#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012383", "name": "C0012383#ent", "pos": [22, 23]}}
{"token": ["That", "amplified", "products", "were", "derived", "from", "C1706240#ent", "<e1>", "verified", "by", "restriction", "C0027203#ent", "<e2>", "mapping", "of", "each", "PCR", "product", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["Thus", "we", "identify", "C1706240#ent", "<e1>", "as", "a", "pivotal", "C0027203#ent", "<e2>", "in", "eliciting", "a", "precise", "subset", "of", "NK", "cell", "responses", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["The", "35S-labeled", "peptide", "pattern", "generated", "from", "the", "C1706240#ent", "<e1>", "the", "mutant", "C0027203#ent", "<e2>", "differs", "markedly", "from", "the", "peptide", "pattern", "of", "the", "wild", "type", "subunit"], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "C1710463#ent", "<e1>", "the", "rat", "C1417932#ent", "<e2>", "transient", "expression", "assays"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [7, 8]}}
{"token": ["The", "diagnosis", "of", "C0032269#ent", "<e1>", "obtained", "in", "15", "cases", "by", "isolating", "C0038395#ent", "<e2>", "."], "h": {"id": "C0032269", "name": "C0032269#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0038395", "name": "C0038395#ent", "pos": [11, 12]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "a", "correlation", "of", "fetotoxicity", "induced", "by", "C1742019#ent", "<e1>", "SA", ")", "analogues", "to", "their", "C0039613#ent", "<e2>", "effect", "."], "h": {"id": "C1742019", "name": "C1742019#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039613", "name": "C0039613#ent", "pos": [20, 21]}}
{"token": ["The", "object", "of", "the", "present", "study", "was", "to", "determine", "the", "maternal", "plasma", "pharmacokinetics", "of", "doxylamine", "(", "the", "C0019592#ent", "<e1>", "component", "of", "C0053098#ent", "<e2>", ")", "following", "Bendectin", "administration"], "h": {"id": "C0019592", "name": "C0019592#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0053098", "name": "C0053098#ent", "pos": [21, 22]}}
{"token": ["Induction", "of", "senescence", "by", "C1333928#ent", "<e1>", "down-regulation", "associated", "with", "activation", "of", "the", "p53", "pathway", "induction", "of", "C3470429#ent", "<e2>", "."], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [16, 17]}}
{"token": ["Mapping", "of", "C0087140#ent", "<e1>", "expression", "showed", "that", "the", "frontoparietal", "cortex", "constantly", "involved", "in", "the", "C0751494#ent", "<e2>", "by", "a", "threshold", "convulsant", "dose", ",", "whereas", "limbic", "participation", "was", "variable", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751494", "name": "C0751494#ent", "pos": [14, 15]}}
{"token": ["Using", "in", "situ", "hybridization", "we", "previously", "investigated", "(", "17", ")", "the", "regional", "pattern", "of", "C0087140#ent", "<e1>", "mRNA", "increases", "in", "the", "brain", "following", "C0751494#ent", "<e2>", "from", "a", "highly", "circumscribed", "epileptogenic", "site", "located", "in", "the", "deep", "prepiriform", "cortex"], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751494", "name": "C0751494#ent", "pos": [22, 23]}}
{"token": ["C0298346#ent", "<e1>", "completely", "blocked", "the", "insulin-induced", "decrease", "of", "the", "C3272517#ent", "<e2>", "and", "CNT2", "mRNAs", "levels", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272517", "name": "C3272517#ent", "pos": [9, 10]}}
{"token": ["Potency", "of", "the", "antihistamine", "effects", "of", "C0527189#ent", "<e1>", ",", "cetirizine", "and", "C0771752#ent", "<e2>", "in", "standard-dose", "application", "were", "compared", "from", "11.5", "to", "24", "h", "after", "application", "."], "h": {"id": "C0527189", "name": "C0527189#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0771752", "name": "C0771752#ent", "pos": [11, 12]}}
{"token": ["C0527189#ent", "<e1>", ",", "like", "d-chlorpheniramine", ",", "reduced", "the", "behavioural", "activity", "while", "C0771752#ent", "<e2>", "had", "no", "effect", "any", "of", "the", "tests", "."], "h": {"id": "C0527189", "name": "C0527189#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0771752", "name": "C0771752#ent", "pos": [11, 12]}}
{"token": ["To", "elucidate", "the", "functional", "consequences", ",", "pharmacological", "properties", "were", "evaluated", "in", "cells", "expressing", "C23", "or", "C1419724#ent", "<e1>", "in", "the", "nonedited", ",", "C1425228#ent", "<e2>", ",", "or", "edited", ",", "VSV", ",", "isoform", "."], "h": {"id": "C1419724", "name": "C1419724#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1425228", "name": "C1425228#ent", "pos": [21, 22]}}
{"token": ["Because", "of", "its", "association", "with", "cancer", ",", "this", "C0079429#ent", "<e1>", "was", "named", "C3273629#ent", "<e2>", "CAGE-1", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273629", "name": "C3273629#ent", "pos": [12, 13]}}
{"token": ["A", "comparison", "of", "the", "cytotoxic", "potencies", "of", "C0077640#ent", "<e1>", ",", "bizelesin", ",", "C0172048#ent", "<e2>", ",", "cisplatin", ",", "and", "doxorubicin", "indicates", "that", "C0077640#ent", "<e1>", "is", "a", "potent", "analog", "of", "CC-1065", "."], "h": {"id": "C0172048", "name": "C0172048#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0077640", "name": "C0077640#ent", "pos": [7, 8]}}
{"token": ["These", "results", "indicate", "that", "the", "pattern", "of", "sequence", "selectivity", "induced", "by", "C0172048#ent", "<e1>", "is", "similar", "but", "not", "identical", "to", "those", "induced", "by", "C0077640#ent", "<e2>", "."], "h": {"id": "C0172048", "name": "C0172048#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0077640", "name": "C0077640#ent", "pos": [22, 23]}}
{"token": ["C0172048#ent", "<e1>", "also", "proved", "to", "be", "more", "efficacious", "than", "U-76074", "or", "C0077640#ent", "<e2>", "against", "mouse", "pancreatic", "ductal", "02", "adenocarcinoma", "a", "system", "reported", "to", "be", "resistant", "to", "every", "agent", "tested", "."], "h": {"id": "C0172048", "name": "C0172048#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0077640", "name": "C0077640#ent", "pos": [11, 12]}}
{"token": ["2", ")", "When", "these", "drugs", "were", "administered", "to", "pregnant", "rats", "rabbits", "intravenously", ",", "the", "tocolytic", "potency", "in", "the", "following", "order", ":", "C0282210#ent", "<e1>", "greater", "than", "C0035661#ent", "<e2>", "greater", "than", "isoxsuprine", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0035661", "name": "C0035661#ent", "pos": [25, 26]}}
{"token": ["Replication", "protein", "A", "RPA", ")", "is", "C3537332#ent", "<e1>", "for", "multiple", "processes", "in", "DNA", "metabolism", "DNA", "replication", "C1333237#ent", "<e2>", "and", "recombination", "."], "h": {"id": "C3537332", "name": "C3537332#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [16, 17]}}
{"token": ["Replication", "protein", "A", "RPA", ",", "also", "known", "as", "human", "C3537332#ent", "<e1>", "is", "a", "trimeric", ",", "multifunctional", "protein", "complex", "in", "DNA", "replication", "C1333237#ent", "<e2>", "and", "recombination", "."], "h": {"id": "C3537332", "name": "C3537332#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [21, 22]}}
{"token": ["Forced", "expression", "of", "CIS1", "inhibits", "C1335875#ent", "<e1>", "activation", "by", "binding", "to", "cytokine", "receptors", "whereas", "CIS3", "and", "C3273630#ent", "<e2>", "directly", "binds", "to", "the", "kinase", "domain", "JAKs", ",", "thereby", "inhibiting", "tyrosine", "kinase", "activity"], "h": {"id": "C1335875", "name": "C1335875#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273630", "name": "C3273630#ent", "pos": [16, 17]}}
{"token": ["Both", "C0035064#ent", "<e1>", "are", "destroyed", "by", "C3540759#ent", "<e2>", "are", "precipitated", "by", "40", "per", "cent", "saturation", "with", "(", "NH(4))(2)SO(4", ")", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540759", "name": "C3540759#ent", "pos": [6, 7]}}
{"token": ["There", "was", "no", "relationship", "between", "the", "type", "or", "site", "within", "the", "C1415063#ent", "<e1>", "the", "mutation", "and", "the", "height", "SDS", "C0123707#ent", "<e2>", "SDS", "of", "the", "patients", "."], "h": {"id": "C1415063", "name": "C1415063#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0123707", "name": "C0123707#ent", "pos": [19, 20]}}
{"token": ["We", "concluded", "that", "the", "GH-independent", "growth", "obese", "Zucker", "rats", "is", "not", "due", "to", "increased", "C1415063#ent", "<e1>", "mRNA", "or", "to", "maintained", "C0123707#ent", "<e2>", "mRNA", "levels", "in", "the", "liver", "."], "h": {"id": "C1415063", "name": "C1415063#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0123707", "name": "C0123707#ent", "pos": [20, 21]}}
{"token": ["This", "disease", "has", "also", "been", "associated", "with", "C0014130#ent", "<e1>", "Cushing's", "syndrome", "hypoparathyroidism", ",", "hypothyroidism", ",", "hyperthyroidism", "and", "C0001403#ent", "<e2>"], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [17, 18]}}
{"token": ["We", "report", "on", "five", "patients", "from", "three", "families", "with", "C0003886#ent", "<e1>", "cholestasis", "and", "C0151747#ent", "<e2>"], "h": {"id": "C0003886", "name": "C0003886#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151747", "name": "C0151747#ent", "pos": [13, 14]}}
{"token": ["The", "C0149512#ent", "<e1>", "accompanied", "by", "an", "enhanced", "C1423842#ent", "<e2>", "IFN-gamma", "response", "."], "h": {"id": "C0149512", "name": "C0149512#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [7, 8]}}
{"token": ["Early", "therapy", "C3540726#ent", "<e1>", "did", "not", "seem", "to", "prevent", "the", "development", "of", "C0037285#ent", "<e2>"], "h": {"id": "C3540726", "name": "C3540726#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "C3540726#ent", "<e1>", "improved", "the", "C0037285#ent", "<e2>", "not", "the", "ischaemia", "."], "h": {"id": "C3540726", "name": "C3540726#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [6, 7]}}
{"token": ["C0007894#ent", "<e1>", "such", "as", "hydatid", "cysts", "C0010709#ent", "<e2>", "are", "known", "to", "cause", "extensive", "tissue", "damage", "while", "other", "larval", "cestodes", ",", "such", "as", "tetrathyridia", ",", "cause", "minimal", "damage", "to", "the", "host", "."], "h": {"id": "C0007894", "name": "C0007894#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [6, 7]}}
{"token": ["Here", "we", "initiated", "studies", "with", "the", "human", "C1334043#ent", "<e1>", "of", "PKG", ",", "the", "C3489929#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3489929", "name": "C3489929#ent", "pos": [13, 14]}}
{"token": ["The", "clustering", "of", "breaks", "in", "intron", "7", "C1332415#ent", "<e1>", "and", "the", "consistent", "\"", "in", "frame", "\"", "C3148863#ent", "<e2>", "therefore", "reflect", "certain", "functional", "constraints", "crucial", "for", "clonal", "outgrowth"], "h": {"id": "C1332415", "name": "C1332415#ent", "pos": [7, 8]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3148863", "name": "C3148863#ent", "pos": [16, 17]}}
{"token": ["Other", "C1257966#ent", "<e1>", "such", "as", "epicatechin", ",", "quercetin", "and", "naringenin", "also", "inhibited", "C0081888#ent", "<e2>"], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0081888", "name": "C0081888#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "C1452494#ent", "<e1>", "(", "also", "called", "C1420470#ent", "<e2>", ")", ",", "a", "member", "of", "the", "Polo", "kinase", "family", "has", "been", "identified", "as", "a", "novel", "positive", "regulator", "of", "centriole", "formation"], "h": {"id": "C1452494", "name": "C1452494#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420470", "name": "C1420470#ent", "pos": [7, 8]}}
{"token": ["C0272327#ent", "<e1>", "GCS", "has", "been", "reported", "in", "6", "patients", "with", "C1387532#ent", "<e2>", "low", "erythrocyte", "levels", "of", "glutathione", "and", "gamma-glutamylcysteine", "."], "h": {"id": "C0272327", "name": "C0272327#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1387532", "name": "C1387532#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "a", "patient", "with", "systemic", "lupus", "erythematosus", "associated", "with", "antiphospholipid", "antibodies", "developed", "C0008489#ent", "<e1>", ",", "which", "has", "been", "considered", "a", "sign", "of", "C0024138#ent", "<e2>", "activity", "."], "h": {"id": "C0008489", "name": "C0008489#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [23, 24]}}
{"token": ["We", "now", "characterize", "an", "C3899989#ent", "<e1>", "dilated", "cardiomyopathy", "cardiac", "conduction-system", "disease", "and", "adult-onset", "limb-girdle", "muscular", "dystrophy", "FDC", ",", "conduction", "disease", "and", "C0026848#ent", "<e2>", "[", "FDC-CDM", "]", ")", "."], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [21, 22]}}
{"token": ["Hypokalemic", "periodic", "paralysis", "hypoPP", ")", "is", "an", "C3899989#ent", "<e1>", "to", "a", "group", "of", "C0026848#ent", "<e2>", "the", "abnormal", "function", "of", "ion", "channels"], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [13, 14]}}
{"token": ["Serum", "samples", "(", "n18", ")", "from", "patients", "presenting", "other", "C0747256#ent", "<e1>", "paragonomiasis", ",", "cysticercosis", ",", "and", "C0015652#ent", "<e2>", ")", "or", "healthy", "blood", "donors", "n15", ")", ",", "were", "designated", "as", "control", "groups"], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0015652", "name": "C0015652#ent", "pos": [16, 17]}}
{"token": ["Such", "clinical", "cases", "physician", "to", "recall", "the", "C0747256#ent", "<e1>", "such", "as", "C0015652#ent", "<e2>", ",", "which", "affects", "hepatobiliary", "system", "causes", "prolongation", "of", "cholestasis", "and", "dystrophic", "changes", "in", "the", "biliary", "tract", "likely", "to", "cause", "liver", "cirrhosis"], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0015652", "name": "C0015652#ent", "pos": [11, 12]}}
{"token": ["These", "results", "also", "suggest", "that", "the", "differential", "sensitivity", "of", "Fanconi's", "Anemia", "cells", "MC", "and", "C1539322#ent", "<e1>", "is", "related", "to", "factors", "other", "than", "a", "selective", "defect", "C1425027#ent", "<e2>"], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1425027", "name": "C1425027#ent", "pos": [25, 26]}}
{"token": ["Phylogenetic", "analysis", "C1417857#ent", "<e1>", "and", "related", "C0086376#ent", "<e2>", "suggests", "that", "the", "members", "of", "the", "AAA", "family", "arose", "from", "different", "ancestors", ",", "since", "the", "ingroup", "was", "not", "monophyletic", "."], "h": {"id": "C1417857", "name": "C1417857#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}}
{"token": ["The", "lymphoid", "lesions", "induced", "in", "rats", "bear", "striking", "similarities", "to", "the", "post", "transplant", "lesions", "in", "patients", "receiving", "C2000261#ent", "<e1>", "and", "in", "patients", "with", "the", "acquired", "C0001175#ent", "<e2>"], "h": {"id": "C2000261", "name": "C2000261#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [25, 26]}}
{"token": ["After", "1", "year", ",", "the", "only", "C0016053#ent", "<e1>", "remaining", "in", "all", "spiked", "trays", "were", "C1367702#ent", "<e2>", "AHTN", "."], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1367702", "name": "C1367702#ent", "pos": [14, 15]}}
{"token": ["We", "stained", "246", "paraffin-embedded", "tissue", "samples", "TRACP", "using", "monoclonal", "antibody", "9C5", "mab9C5", ")", "to", "isoforms", "5a", "C0537987#ent", "<e1>", "and", "a", "novel", "mab220", "specific", "to", "C0597298#ent", "<e2>"], "h": {"id": "C0537987", "name": "C0537987#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [24, 25]}}
{"token": ["Human", "GRF", "(", "hGRF", ")", "activates", "C0001492#ent", "<e1>", "normal", "human", "C0032002#ent", "<e2>", "in", "a", "concentration", "dependent", "manner", "(", "ED5", "0", "=", "10(-11", ")", "M", ")", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [10, 11]}}
{"token": ["The", "native", "and", "synthetic", "hormones", "identical", "wide", "ranging", "effects", "(", "possibly", "through", "particulate", "guanylate", "cyclase", "stimulation", "and", "C0001492#ent", "<e1>", "inhibition", ")", "on", "the", "kidney", ",", "blood", "vessels", "adrenal", "cortex", "and", "C0032002#ent", "<e2>", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [30, 31]}}
{"token": ["C1858517#ent", "<e1>", "results", "from", "mutations", "in", "the", "C0017337#ent", "<e2>", "encoding", "the", "immunoglobulin", "micro-binding", "protein", "2", "IGHMBP2", ")", "on", "chromosome", "11q13"], "h": {"id": "C1858517", "name": "C1858517#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}}
{"token": ["A", "DXEE", "motif", "served", "to", "target", "C1419221#ent", "<e1>", "to", "the", "C1423498#ent", "<e2>", "."], "h": {"id": "C1419221", "name": "C1419221#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423498", "name": "C1423498#ent", "pos": [10, 11]}}
{"token": ["The", "raised", "levels", "of", "IgG", "and", "C1706005#ent", "<e1>", "in", "cases", "of", "C0024449#ent", "<e2>", "caused", "by", "S.", "madurae", "and", "S.", "somaliensis", "where", "bones", "were", "involved", ",", "were", "not", "statistically", "significant"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024449", "name": "C0024449#ent", "pos": [11, 12]}}
{"token": ["The", "authors", "report", "a", "patient", "with", "concomitant", "C0151449#ent", "<e1>", "chronic", "hepatitis", "C.", "associations", "between", "autoimmune", "liver", "disease", "C0524910#ent", "<e2>", "and", "C0151449#ent", "<e1>", "been", "demonstrated", "."], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524910", "name": "C0524910#ent", "pos": [17, 18]}}
{"token": ["However", ",", "administration", "of", "the", "thiazolidinedione", "BRL49653", ",", "a", "C1335238#ent", "<e1>", "increased", "food", "intake", "adipose", "tissue", "while", "reducing", "C1413269#ent", "<e2>", "mRNA", "levels", "in", "rats", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413269", "name": "C1413269#ent", "pos": [18, 19]}}
{"token": ["Preliminary", "results", "from", "clinical", "trials", "demonstrated", "that", "telithromycin", "may", "provide", "a", "convenient", "and", "effective", "compact", "treatment", "option", "for", "select", "C0035243#ent", "<e1>", "as", "community-acquired", "pneumonia", "acute", "bacteria", "exacerbations", "of", "chronic", "bronchitis", "acute", "sinusitis", "C0749591#ent", "<e2>", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0749591", "name": "C0749591#ent", "pos": [32, 33]}}
{"token": ["Clinical", "trials", "cefprozil", "have", "consistently", "demonstrated", "good", "clinical", "success", "rates", "in", "upper", "and", "lower", "C0035243#ent", "<e1>", "including", "otitis", "media", "sinusitis", ",", "C0749591#ent", "<e2>", "acute", "bacterial", "exacerbations", "of", "chronic", "bronchitis"], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0749591", "name": "C0749591#ent", "pos": [21, 22]}}
{"token": ["The", "DD3", "gene", "mapped", "to", "chromosome", "9q21", "22", ",", "and", "no", "homology", "of", "C1412321#ent", "<e1>", "to", "any", "C0017337#ent", "<e2>", "present", "in", "the", "computer", "databases", "found", "."], "h": {"id": "C1412321", "name": "C1412321#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "C1412321#ent", "<e1>", "appears", "to", "participate", "with", "SusR", "in", "regulation", "of", "the", "C0017337#ent", "<e2>"], "h": {"id": "C1412321", "name": "C1412321#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["The", "C0304512#ent", "<e1>", "phentolamine", "and", "the", "C0001640#ent", "<e2>", "prazosin", "inhibited", "an", "increase", "of", "testosterone", "level", "in", "the", "peripheral", "blood", "plasma", "by", "the", "presence", "of", "a", "female", "."], "h": {"id": "C0304512", "name": "C0304512#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [6, 7]}}
{"token": ["Prazosin", ",", "an", "C0304512#ent", "<e1>", "blocked", "the", "effects", "of", "l-epinephrine", "and", "methoxamine", ",", "an", "C0001640#ent", "<e2>", "stimulated", "prazosin-", "and", "furosemide-sensitive", "Cl", "transport"], "h": {"id": "C0304512", "name": "C0304512#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [14, 15]}}
{"token": ["These", "experiments", "suggest", "that", "heparin", "can", "inhibit", "C3888088#ent", "<e1>", "proliferation", "in", "part", "by", "removal", "of", "released", "C1522505#ent", "<e2>", "from", "sites", "of", "injury", "."], "h": {"id": "C3888088", "name": "C3888088#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1522505", "name": "C1522505#ent", "pos": [16, 17]}}
{"token": ["Collectively", ",", "our", "data", "speak", "for", "a", "direct", "involvement", "of", "C1415677#ent", "<e1>", "in", "the", "control", "of", "C0010803#ent", "<e2>", "expression", "during", "early", "trichocyte", "differentiation", "."], "h": {"id": "C1415677", "name": "C1415677#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [16, 17]}}
{"token": ["C0772454#ent", "<e1>", "be", "a", "useful", "C0003292#ent", "<e2>"], "h": {"id": "C0772454", "name": "C0772454#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003292", "name": "C0003292#ent", "pos": [5, 6]}}
{"token": ["In", "situ", "hybridization", "C0020498#ent", "<e1>", ")", "of", "adult", "bone", "is", "a", "difficult", "C0310298#ent", "<e2>", "that", "requires", "at", "least", "3", "-", "5", "weeks", "for", "decalcification", ",", "paraffin", "embedding", "and", "sectioning", "."], "h": {"id": "C0020498", "name": "C0020498#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [12, 13]}}
{"token": ["Our", "data", "also", "show", "that", ",", "in", "comparison", "to", "wild-type", "C1413769#ent", "<e1>", ",", "the", "capacity", "of", "the", "C0298973#ent", "<e2>", "bind", "both", "N-RAP", "and", "alpha-actinin", "is", "significantly", "decreased", "."], "h": {"id": "C1413769", "name": "C1413769#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0298973", "name": "C0298973#ent", "pos": [17, 18]}}
{"token": ["With", "3", "mM", "C2744579#ent", "<e1>", ",", "the", "Na+-ATPase", "was", "less", "sensitive", "to", "C1705551#ent", "<e2>", "than", "the", "(", "Na+", "+", "K+)-ATPase", "activity"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705551", "name": "C1705551#ent", "pos": [12, 13]}}
{"token": ["Incubation", "of", "microtubule", "protein", "C2744579#ent", "<e1>", "and", "cAMP", "in", "5", "mM", "C1705551#ent", "<e2>", "resulted", "in", "exchange", "but", "no", "net", "addition", "of", "phosphate", "to", "MAPs", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705551", "name": "C1705551#ent", "pos": [11, 12]}}
{"token": ["Neuromuscular", "blocks", "by", "succinylcholine", "and", "C0282372#ent", "<e1>", "were", "not", "altered", "by", "C0885378#ent", "<e2>", "."], "h": {"id": "C0282372", "name": "C0282372#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0885378", "name": "C0885378#ent", "pos": [11, 12]}}
{"token": ["Enhanced", "Ca2", "+", "spark", "frequency", "also", "seen", "in", "C0039902#ent", "<e1>", "at", "4", "weeks", "(", "before", "C0018801#ent", "<e2>", "onset", ")", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [15, 16]}}
{"token": ["C0907533#ent", "<e1>", "expression", "of", "C1538857#ent", "<e2>", "suppressed", "the", "actin", "cytoskeletal", "focal", "adhesion", "mediated", "by", "B-RAF", "knockdown", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538857", "name": "C1538857#ent", "pos": [4, 5]}}
{"token": ["The", "depression", "of", "this", "mechanism", "at", "mid-pregnancy", "followed", "by", "its", "C0907533#ent", "<e1>", "activation", "near", "term", "is", "associated", "with", "co-ordinated", "modulation", "of", "C1538857#ent", "<e2>", ",", "RhoA", "and", "Rho", "kinase", "expression", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1538857", "name": "C1538857#ent", "pos": [21, 22]}}
{"token": ["It", "was", "striking", "that", "only", "the", "expanded", "C3811251#ent", "<e1>", "altered", ",", "leaving", "the", "C0002085#ent", "<e2>", "(CTG)(12", ")", ",", "and", "other", "repeat", "loci", "."], "h": {"id": "C3811251", "name": "C3811251#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [13, 14]}}
{"token": ["Reassuringly", ",", "most", "children", "with", "neonatal", "C0024141#ent", "<e1>", "not", "develop", "C0035435#ent", "<e2>", "although", "follow-up", "is", "limited", "to", "late", "adolescence"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [10, 11]}}
{"token": ["And", "we", "also", "evaluated", "FDP/D-dimer", "levels", "of", "14", "patients", "with", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e1>", ")", "and", "12", "patients", "with", "other", "C0035435#ent", "<e2>", "control", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [21, 22]}}
{"token": ["The", "use", "of", "verapamil", "should", "be", "avoided", "in", "the", "presence", "of", "C0037052#ent", "<e1>", "clinical", "cardiac", "failure", "treatment", "with", "other", "negative", "C0013227#ent", "<e2>"], "h": {"id": "C0037052", "name": "C0037052#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [20, 21]}}
{"token": ["Niemann", "Pick", "disease", "type", "C1", "C3179455#ent", "<e1>", ")", "is", "an", "inherited", ",", "C3899988#ent", "<e2>", "lipid-storage", "disorder", "with", "major", "neurological", "involvement", "."], "h": {"id": "C3179455", "name": "C3179455#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [12, 13]}}
{"token": ["Nevertheless", ",", "the", "increased", "consumption", "of", "C0001962#ent", "<e1>", "may", "contribute", "to", "the", "C0458219#ent", "<e2>"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0458219", "name": "C0458219#ent", "pos": [12, 13]}}
{"token": ["Endocranial", "development", "an", "osteoma", "can", "breach", "the", "dura", "mata", "allowing", "air", "to", "enter", "the", "cranium", "producing", "C0032268#ent", "<e1>", "which", "leads", "to", "severe", "C0175683#ent", "<e2>"], "h": {"id": "C0032268", "name": "C0032268#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0175683", "name": "C0175683#ent", "pos": [22, 23]}}
{"token": ["A", "C0004623#ent", "<e1>", "documented", "in", "four", "patients", ",", "C0006840#ent", "<e2>", "seven", "patients", "and", "one", "patient", "died", "from", "Candida", "parakrusei", "septicaemia"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [8, 9]}}
{"token": ["C0039847#ent", "<e1>", "TPPase", ")", "and", "nicotinamide", "adenine", "dinucleotide", "phosphatase", "C0131762#ent", "<e2>", ")", "were", "found", "in", "the", "saccules", ",", "being", "on", "the", "mature", "surface", "and", "in", "the", "intermediate", "saccules", "parabasal", "body", "stacks", ",", "respectively", "."], "h": {"id": "C0039847", "name": "C0039847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0131762", "name": "C0131762#ent", "pos": [9, 10]}}
{"token": ["The", "reactions", "of", "C0039847#ent", "<e1>", "TPPase", ")", "and", "nicotinamide", "adenine", "dinucleotide", "phosphatase", "C0131762#ent", "<e2>", ")", "were", "both", "negative", ",", "indicating", "that", "E.", "histolytica", "Golgi", "body"], "h": {"id": "C0039847", "name": "C0039847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0131762", "name": "C0131762#ent", "pos": [12, 13]}}
{"token": ["Both", "C2986885#ent", "<e1>", "and", "M7", "assumed", "helical", "conformations", "25", "mM", "C0272170#ent", "<e2>", "."], "h": {"id": "C2986885", "name": "C2986885#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [10, 11]}}
{"token": ["To", "evaluate", "the", "prevalence", "and", "factors", "influencing", "the", "presence", "of", "concomitant", "C0037274#ent", "<e1>", "in", "patients", "with", "C0040261#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0040261", "name": "C0040261#ent", "pos": [16, 17]}}
{"token": ["All", "four", "proteins", "(", "C0027021#ent", "<e1>", "peroxidase", "precursor", ",", "amine", "oxidase", "C0023835#ent", "<e2>", ")", "were", "defence-related", "and", "their", "involvement", "in", "the", "oxidative", "burst", "discussed", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023835", "name": "C0023835#ent", "pos": [11, 12]}}
{"token": ["C1705027#ent", "<e1>", "is", "a", "member", "of", "the", "C0026902#ent", "<e2>", "proto-oncogenes", "which", "encode", "nuclear", "proteins", "form", "heterodimers", "with", "MAX", "protein", "their", "conserved", "HLHZip", "domains", "."], "h": {"id": "C1705027", "name": "C1705027#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026902", "name": "C0026902#ent", "pos": [7, 8]}}
{"token": ["The", "lignin", "peroxidase", "C1846919#ent", "<e1>", ")", "encoding", "gene", "may", "be", "sensitive", "to", "C1539312#ent", "<e2>", "stress", "."], "h": {"id": "C1846919", "name": "C1846919#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [12, 13]}}
{"token": ["It", "is", "known", "that", "C0086661#ent", "<e1>", "regulates", "the", "expression", "of", "TERT", ",", "the", "C0754515#ent", "<e2>", "by", "binding", "to", "E", "box"], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0754515", "name": "C0754515#ent", "pos": [13, 14]}}
{"token": ["Delta1-pyrroline-5-carboxylate", "is", "formed", "in", "liver", "from", "proline", "by", "C0033385#ent", "<e1>", "EC", "number", "not", "assigned", ")", "or", "from", "ornithine", "via", "C0029278#ent", "<e2>"], "h": {"id": "C0033385", "name": "C0033385#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029278", "name": "C0029278#ent", "pos": [19, 20]}}
{"token": ["The", "hypertension", "was", "due", "to", "long-standing", "C1623038#ent", "<e1>", "in", "4", "patients", ";", "the", "other", "3", "patients", "had", "C1696708#ent", "<e2>", "to", "thrombosis", "involving", "the", "portal", "vein", "1", "and", "the", "splenoportal", "confluence", "in", "2", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1696708", "name": "C1696708#ent", "pos": [17, 18]}}
{"token": ["The", "seizure", "types", "in", "C1840252#ent", "<e1>", "are", "typical", "absences", ",", "C0027066#ent", "<e2>", "and", "generalized", "tonic-clonic", "seizures", "TCS", ")", ",", "alone", "or", "in", "varying", "combinations", "and", "with", "variable", "severity", "."], "h": {"id": "C1840252", "name": "C1840252#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027066", "name": "C0027066#ent", "pos": [10, 11]}}
{"token": ["The", "relative", "relationship", "between", "C1705240#ent", "<e1>", "and", "C1705240#ent", "<e1>", ",", "calc", "of", "C0015772#ent", "<e1>", "was", "substantially", "identical", "with", "eight", "other", "calcium", "channel", "blocking", "agents", "reported", "previously", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [12, 13]}}
{"token": ["We", "report", "about", "a", "patient", "with", "human", "immunodeficiency", "virus", "infection", "developed", "C0022660#ent", "<e1>", "therapy", "with", "C1145759#ent", "<e2>", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1145759", "name": "C1145759#ent", "pos": [15, 16]}}
{"token": ["In", "addition", "to", "this", "triad", ",", "a", "number", "of", "other", "autoimmune", "diseases", "been", "observed", "in", "C0085859#ent", "<e1>", "patients", "including", "Sj\u00f6gren's", "syndrome", "C0042900#ent", "<e2>", ",", "alopecia", ",", "uveitis", ",", "and", "others", "."], "h": {"id": "C0085859", "name": "C0085859#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [21, 22]}}
{"token": ["We", "have", "identified", "C1424640#ent", "<e1>", "and", "C1705621#ent", "<e2>", "and", "examined", "C1424640#ent", "<e1>", "as", "a", "possible", "link", "between", "phosphoinositide-", ",", "Arf-", ",", "and", "Rho-mediated", "cell", "signaling", "."], "h": {"id": "C1705621", "name": "C1705621#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1424640", "name": "C1424640#ent", "pos": [3, 4]}}
{"token": ["We", "show", "that", "in", "the", "absence", "of", "its", "ligand-binding", "domain", "the", "glucocorticoid", "receptor", "C1705401#ent", "<e1>", ")", "is", "able", "to", "interact", "with", "both", "nuclear", "receptor", "coactivators", "the", "C1706022#ent", "<e2>", "chromatin-remodeling", "complex", "in", "vivo"], "h": {"id": "C1705401", "name": "C1705401#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706022", "name": "C1706022#ent", "pos": [26, 27]}}
{"token": ["Symptoms", "began", "with", "C0030554#ent", "<e1>", "of", "the", "feet", "and", "progressed", "to", "a", "C0030481#ent", "<e2>", "clinical", "signs", "both", "lateral", "and", "dorsal", "column", "involvement", "."], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030481", "name": "C0030481#ent", "pos": [12, 13]}}
{"token": ["Based", "on", "studying", "the", "data", "obtained", "during", "examination", "of", "patients", "with", "C1419789#ent", "<e1>", "combined", "with", "the", "urinary", "syndrome", "varieties", "of", "C0022658#ent", "<e2>", "namely", "chronic", "glomerulonephritis", "CGN", ")", "and", "amyloidosis", "were", "distinguished", "."], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [20, 21]}}
{"token": ["After", "infection", ",", "cells", "were", "plated", "in", "a", "clonogenic", "methylcellulose", "culture", "in", "the", "absence", "of", "exogenous", "growth", "factors", "as", "C1334117#ent", "<e1>", "IL", "3", "and", "erythropoietin", "(", "C1705819#ent", "<e2>", ")", "."], "h": {"id": "C1334117", "name": "C1334117#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705819", "name": "C1705819#ent", "pos": [26, 27]}}
{"token": ["Among", "a", "family", "of", "C1334117#ent", "<e1>", "only", "unlabeled", "C1705819#ent", "<e2>", "was", "able", "to", "compete", "for", "the", "binding", "of", "radioiodinated", "C1705819#ent", "<e2>", "to", "the", "cells", "."], "h": {"id": "C1334117", "name": "C1334117#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705819", "name": "C1705819#ent", "pos": [8, 9]}}
{"token": ["C1334117#ent", "<e1>", "IL-3", ")", "slightly", "enhanced", "but", "erythropoietin", "(", "C1705819#ent", "<e2>", ")", "did", "not", "alter", "the", "colony", "number", "of", "WEHI-3B-Y1", "cells", "."], "h": {"id": "C1334117", "name": "C1334117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705819", "name": "C1705819#ent", "pos": [9, 10]}}
{"token": ["As", "many", "C0030946#ent", "<e1>", "have", "cognate", "serpins", "regulate", "their", "proteolytic", "activity", "we", "have", "been", "investigating", "C0147080#ent", "<e2>", ",", "expressed", "during", "this", "window", "of", "implantation", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0147080", "name": "C0147080#ent", "pos": [15, 16]}}
{"token": ["Part", "1", "of", "this", "two-part", "series", "focuses", "on", "the", "use", "of", "the", "C3640976#ent", "<e1>", "rhG-CSF", "and", "rhGM-CSF", "to", "shorten", "the", "C2926735#ent", "<e2>", "of", "chemotherapy-induced", "neutropenia", "thus", "prevent", "infection", "in", "cancer", "patients", "."], "h": {"id": "C3640976", "name": "C3640976#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [20, 21]}}
{"token": ["Their", "activities", "as", "the", "inhibitor", "of", "C0920283#ent", "<e1>", "were", "well", "correlated", "with", "those", "as", "the", "cofactor", "of", "C0001473#ent", "<e2>", "."], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [17, 18]}}
{"token": ["Mutation", "of", "this", "serine", "residue", "C0920283#ent", "<e1>", "histidine", "or", "methionine", "leads", "to", "proteins", "with", "unaffected", "C0001473#ent", "<e2>", "and", "DNA-binding", "activities", "with", "low", "helicase", "activity", "."], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "C1143167#ent", "<e1>", "be", "restricting", "viral", "growth", "infected", "individuals", "through", "a", "mechanism", "that", "is", "independent", "of", "the", "C0010723#ent", "<e2>", "activities", "of", "C1143167#ent", "<e1>"], "h": {"id": "C0010723", "name": "C0010723#ent", "pos": [18, 19]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1143167", "name": "C1143167#ent", "pos": [2, 3]}}
{"token": ["We", "have", "recently", "shown", "that", "during", "C0025229#ent", "<e1>", ",", "a", "severe", "infection", "caused", "by", "the", "gram-negative", "bacterium", "Burkholderia", "pseudomallei", "C1336634#ent", "<e2>", "but", "not", "TLR4", "impacts", "the", "immune", "response", "the", "intact", "host", "in", "vivo"], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336634", "name": "C1336634#ent", "pos": [19, 20]}}
{"token": ["C0083381#ent", "<e1>", "has", "been", "extensively", "studied", "in", "C0029408#ent", "<e2>", "patients", "and", "combines", "antiinflammatory", "efficacy", "a", "lower", "incidence", "of", "GI", "toxicity", "than", "currently", "available", "NSAIDs", "."], "h": {"id": "C0083381", "name": "C0083381#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [7, 8]}}
{"token": ["These", "results", "indicate", "that", "the", "rice", "Golgi", "enzyme", "is", "a", "C0069155#ent", "<e1>", "is", "specific", "for", "C2827560#ent", "<e2>", ",", "UDP", ",", "and", "GDP", "."], "h": {"id": "C0069155", "name": "C0069155#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2827560", "name": "C2827560#ent", "pos": [15, 16]}}
{"token": ["Sensory", "ataxic", "neuropathy", "C0751401#ent", "<e1>", "(", "SANDO", ")", "caused", "by", "mutations", "in", "C1423109#ent", "<e2>", "fulfilling", "the", "clinical", "triad", "sensory", "ataxic", "neuropathy", "dysarthria", "and/or", "dysphagia", "and", "C0751401#ent", "<e1>", ",", "has", "described", "in", "a", "few", "reports", "."], "h": {"id": "C0751401", "name": "C0751401#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423109", "name": "C1423109#ent", "pos": [12, 13]}}
{"token": ["The", "same", "region", "also", "has", "significant", "homology", "with", "the", "human", "D2", "germ-line", "mini-gene", "sequence", ",", "especially", "with", "a", "14-nucleotide", "sequence", "shown", "to", "be", "C1334043#ent", "<e1>", "to", "human", "and", "rabbit", "C1420192#ent", "<e2>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [29, 30]}}
{"token": ["The", "results", "show", "that", "protein", "subregions", "responsible", "for", "basic", "functions", "of", "myosin", "heavy", "chains", "nucleotide", "binding", "actin", "binding", "are", "very", "similar", "in", "C1334043#ent", "<e1>", "and", "heterologous", "C1420192#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [26, 27]}}
{"token": ["In", "cell", "culture", "studies", "the", "rhBMP-7", "produced", "in", "BTCs", "stimulated", "the", "specific", "activity", "of", "C1706468#ent", "<e1>", ",", "the", "production", "of", "cAMP", "in", "response", "to", "C1705340#ent", "<e2>", ",", "and", "the", "synthesis", "of", "osteocalcin", "."], "h": {"id": "C1706468", "name": "C1706468#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [24, 25]}}
{"token": ["The", "effects", "of", "C1418945#ent", "<e1>", "inhibitors", "such", "as", "C0056650#ent", "<e2>", ",", "hydroxylamine", ",", "and", "azide", "have", "also", "been", "studied", "."], "h": {"id": "C1418945", "name": "C1418945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0056650", "name": "C0056650#ent", "pos": [8, 9]}}
{"token": ["Given", "the", "numerous", "possible", "underlying", "causes", "for", "acquired", "C1414172#ent", "<e1>", ",", "evaluation", "of", "patients", "presenting", "with", "acquired", "C2987230#ent", "<e2>", "can", "be", "a", "perplexing", "task", "."], "h": {"id": "C1414172", "name": "C1414172#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987230", "name": "C2987230#ent", "pos": [17, 18]}}
{"token": ["C0023067#ent", "<e1>", "secondary", "to", "gastric", "acid", "reflux", "a", "prevalent", ",", "yet", "incompletely", "understood", ",", "C0029896#ent", "<e2>"], "h": {"id": "C0023067", "name": "C0023067#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}}
{"token": ["The", "type", "II", "inhibitor", "Mr", "approximately", "or", "equal", "to", "15,000", ")", "competes", "for", "the", "C0027203#ent", "<e1>", "with", "various", "substrate", "proteins", "histone", ",", "alpha-casein", ",", "and", "C0064282#ent", "<e2>", "kemptide", ")", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0064282", "name": "C0064282#ent", "pos": [25, 26]}}
{"token": ["However", ",", "CMT-cGMP", "activated", "the", "C0027203#ent", "<e1>", "to", "the", "same", "level", "as", "cGMP", "when", "1.3", "mM", "C0064282#ent", "<e2>", "was", "present", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0064282", "name": "C0064282#ent", "pos": [16, 17]}}
{"token": ["min(-1", ")", ")", "was", "evaluated", "in", "anesthetized", "dogs", "pretreated", "with", "vehicle", ",", "a", "selective", "C1737955#ent", "<e1>", "nimesulide", ")", ",", "or", "a", "nonselective", "COX", "inhibitor", "C1289957#ent", "<e2>", ")", "."], "h": {"id": "C1737955", "name": "C1737955#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1289957", "name": "C1289957#ent", "pos": [24, 25]}}
{"token": ["A", "3-year-old", "male", "with", "C0220754#ent", "<e1>", "with", "rash", ",", "C0004134#ent", "<e2>", ",", "and", "paraparesis", "and", "magnetic", "resonance", "imaging", "findings", "of", "myelopathy", "."], "h": {"id": "C0220754", "name": "C0220754#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [9, 10]}}
{"token": ["C0220754#ent", "<e1>", "characterized", "clinically", "by", "skin", "rash", "alopecia", ",", "seizures", "and", "C0004134#ent", "<e2>", "and", "occasionally", "by", "candidiasis", "and", "developmental", "delay"], "h": {"id": "C0220754", "name": "C0220754#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [11, 12]}}
{"token": ["Symptoms", "of", "the", "C0024586#ent", "<e1>", "caused", "by", "an", "excess", "of", "biogenic", "amines", "C0030956#ent", "<e2>", "and", "other", "factors", "in", "the", "circulation", "."], "h": {"id": "C0024586", "name": "C0024586#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["The", "C0024586#ent", "<e1>", "from", "the", "variety", "of", "amines", "and", "C0030956#ent", "<e2>", "produced", "by", "this", "tumor", "is", "usually", "apparent", "once", "there", "are", "metastases", "to", "the", "liver", "."], "h": {"id": "C0024586", "name": "C0024586#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}}
{"token": ["These", "data", "suggest", "that", "C1705526#ent", "<e1>", "regulates", "distinct", "genes", "via", "different", "binding", "mechanisms", "and", "that", "C1414185#ent", "<e2>", "is", "an", "essential", "target", "of", "C1705526#ent", "<e1>", "in", "signaling", "apoptosis"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414185", "name": "C1414185#ent", "pos": [15, 16]}}
{"token": ["This", "article", "specifically", "focuses", "on", "diagnostic", "criteria", "classifications", "of", "C0235025#ent", "<e1>", "including", "diabetic", ",", "alcoholic", ",", "carcinomatous", ",", "human", "immunodeficiency", "virus-associated", "and", "C1135188#ent", "<e2>"], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1135188", "name": "C1135188#ent", "pos": [22, 23]}}
{"token": ["Incidence", "of", "sudden", "cardiac", "death", "C0342788#ent", "<e1>", ")", "is", "increasing", "yearly", "all", "over", "the", "world", ",", "and", "C0342788#ent", "<e1>", "has", "become", "the", "largest", "C1336644#ent", "<e1>", "of", "all", "diseases", "."], "h": {"id": "C0342788", "name": "C0342788#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336644", "name": "C1336644#ent", "pos": [23, 24]}}
{"token": ["This", "study", "was", "performed", "to", "quantify", "the", "risk", "of", "C0035086#ent", "<e1>", "patients", "using", "C0368663#ent", "<e2>", "(", "5-ASA", ")", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0368663", "name": "C0368663#ent", "pos": [13, 14]}}
{"token": ["The", "KiS", "for", "C2987634#ent", "<e1>", "competition", "of", "3H-nicotine", "binding", "indicate", "C2987634#ent", "<e1>", "affinities", "several", "orders", "of", "magnitude", "greater", "than", "do", "the", "C0609830#ent", "<e1>", "measured", "for", "receptor", "activation"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0609830", "name": "C0609830#ent", "pos": [21, 22]}}
{"token": ["Dysfunction", "or", "dysregulation", "of", "these", "afferent", "and", "efferent", "nerves", "contributes", "to", "the", "pathogenesis", "of", "obstructive", "airways", "diseases", "may", "account", "for", "the", "pulmonary", "symptoms", "associated", "with", "C0024115#ent", "<e1>", "including", "gastroesophageal", "reflux", "disease", "cardiovascular", "disease", "and", "C0149516#ent", "<e2>", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0149516", "name": "C0149516#ent", "pos": [34, 35]}}
{"token": ["It", "is", "concluded", "that", "C0162745#ent", "<e1>", "is", "a", "C0596918#ent", "<e2>", "forms", "an", "inactive", "and", "unstable", "apoenzyme", "on", "treatment", "with", "chelators", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0596918", "name": "C0596918#ent", "pos": [8, 9]}}
{"token": ["In", "the", "present", "experiments", ",", "lysosomotropic", "agents", ",", "C0008269#ent", "<e1>", ",", "ammonium", "chloride", "methylamine", ",", "in", "the", "presence", "of", "C1418938#ent", "<e2>", "are", "capable", "of", "almost", "completely", "preventing", "this", "down-regulation", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [19, 20]}}
{"token": ["Neither", "C0008269#ent", "<e1>", "nor", "NH4Cl", "altered", "the", "lactogenic", "action", "of", "C1418938#ent", "<e2>", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [10, 11]}}
{"token": ["C0008269#ent", "<e1>", ",", "a", "blocker", "of", "phospholipase", "A2", "activity", "decreased", "C1418938#ent", "<e2>", "but", "not", "arachidonic", "acid", "stimulation", "of", "casein", "secretion"], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [10, 11]}}
{"token": ["Comparison", "of", "toxic", "effects", "on", "cell", "viability", "adenine", "nucleotide", "levels", "that", "C0053508#ent", "<e1>", "was", "more", "toxic", "than", "tropolone", "or", "tropone", "in", "Krebs-Henseleit", "buffer", "C0013618#ent", "<e2>", "(", "4", "mM", ")", "."], "h": {"id": "C0053508", "name": "C0053508#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [23, 24]}}
{"token": ["After", "combined", "C1420369#ent", "<e1>", "and", "beta-2", "adrenergic", "receptor", "blockade", "with", "C0033497#ent", "<e2>", ",", "ISO", "induced", "no", "significant", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [10, 11]}}
{"token": ["When", "given", "in", "equipotent", "C1420369#ent", "<e1>", "blocking", "doses", ",", "the", "nonselective", "blocker", "C0033497#ent", "<e2>", "and", "the", "C1420369#ent", "<e1>", "selective", "blocker", "metoprolol", "differ", "markedly", "as", "regards", "inhibition", "of", "adrenaline", "induced", "beta2", "mediated", "vasodilatation", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [12, 13]}}
{"token": ["C0647362#ent", "<e1>", ",", "an", "immobilized", "C0027203#ent", "<e2>", "preparation", "for", "hydrolyzing", "cyanide", "to", "ammonia", "and", "formate", ",", "was", "applied", "for", "the", "treatment", "of", "cyanide-containing", "waste", "waters", "the", "food", "industry"], "h": {"id": "C0647362", "name": "C0647362#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}}
{"token": ["A", "65-year-old", "woman", "with", "aortic", "stenosis", "ischemic", "heart", "disease", "and", "C0339143#ent", "<e1>", "complained", "of", "C0002962#ent", "<e2>"], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [14, 15]}}
{"token": ["Defects", "in", "the", "human", "Ca(2+)-sensing", "receptor", "gene", "have", "recently", "been", "shown", "to", "cause", "C4048195#ent", "<e1>", "neonatal", "severe", "C0020502#ent", "<e2>", "."], "h": {"id": "C4048195", "name": "C4048195#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020502", "name": "C0020502#ent", "pos": [17, 18]}}
{"token": ["Pretreatment", "of", "adult", "rats", "or", "immature", "rabbits", "with", "salicylic", "acid", "C1161334#ent", "<e1>", "phenobarbital", "had", "little", "effect", "on", "C0061595#ent", "<e2>", "in", "vitro", "liver", "or", "kidney", "."], "h": {"id": "C1161334", "name": "C1161334#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0061595", "name": "C0061595#ent", "pos": [17, 18]}}
{"token": ["These", "peptidomimetic", "derivatives", "prevent", "association", "of", "the", "two", "subunits", "of", "herpes", "simplex", "virus", "C0019348#ent", "<e1>", ")", "ribonucleotide", "reductase", "RR", ")", ",", "an", "C0014442#ent", "<e2>", "necessary", "for", "efficient", "replication", "of", "viral", "DNA"], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [22, 23]}}
{"token": ["The", "[Ca2+]i", "increase", "induced", "by", "5", "microM", "C0039286#ent", "<e1>", "was", "not", "altered", "by", "10", "microM", "La3", "+", ",", "C0028066#ent", "<e2>", ",", "verapamil", ",", "and", "diltiazem", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [18, 19]}}
{"token": ["The", "[Ca(2+)]i", "increase", "induced", "by", "10", "microM", "C0039286#ent", "<e1>", "was", "not", "altered", "by", "10", "microM", "of", "C0028066#ent", "<e2>", ",", "verapamil", "and", "diltiazem", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [16, 17]}}
{"token": ["At", "late", "phase", "JNK", "and", "C1366882#ent", "<e1>", "activity", ",", "only", "a", "high", "dose", "C0282210#ent", "<e2>", "increased", "JNK", "."], "h": {"id": "C1366882", "name": "C1366882#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [13, 14]}}
{"token": ["The", "tissue-specific", "expression", "cat2", "had", "a", "strong", "resemblance", "to", "that", "of", "C0061640#ent", "<e1>", "a", "characteristic", "C0027203#ent", "<e2>", "of", "leaf", "peroxisomes", "."], "h": {"id": "C0061640", "name": "C0061640#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["Eighteen", "of", "25", "C1418948#ent", "<e1>", "showed", "5.02", "+", "/-", "4.74", "fold", "overexpression", "of", "C0086661#ent", "<e2>", "oncogene", ",", "6", "of", "19", "C1418948#ent", "<e1>", "had", "4.91", "+", "/-", "3.87", "fold", "overexpression", "of", "c-Ha-ras", "oncogene", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418948", "name": "C1418948#ent", "pos": [3, 4]}}
{"token": ["Thus", ",", "in", "the", "rat", "terminal", "IMCD", ",", "both", "urea", "and", "C0772110#ent", "<e1>", "transport", "are", "stimulated", "by", "AVP", "and", "C0268009#ent", "<e2>", ",", "and", "both", "are", "inhibited", "by", "phloretin", "and", "thiourea", "."], "h": {"id": "C0772110", "name": "C0772110#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268009", "name": "C0268009#ent", "pos": [19, 20]}}
{"token": ["Skin", "ulcers", "be", "very", "C0030193#ent", "<e1>", "and", "detrimental", "in", "patients", "with", "C1290138#ent", "<e2>", "or", "systemic", "scleroderma"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [11, 12]}}
{"token": ["Skin", "ulcers", "be", "very", "C0030193#ent", "<e1>", "and", "detrimental", "in", "patients", "with", "systemic", "sclerosis", "or", "C1290138#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [14, 15]}}
{"token": ["Two", "possible", "pathways", "for", "C0036442#ent", "<e1>", "biosynthesis", "are", "discussed", "in", "the", "light", "of", "the", "C0388250#ent", "<e2>", "and", "epoxidase", "activities", "in", "the", "partially", "purified", "preparation", "of", "hyoscyamine", "6", "beta-hydroxylase", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0388250", "name": "C0388250#ent", "pos": [14, 15]}}
{"token": ["However", ",", "phencyclidines", "have", "comparable", "potency", "to", "that", "of", "C0041345#ent", "<e1>", "in", "blocking", "the", "nicotinic", "receptor", "the", "isolated", "frog", "rectus", "abdominis", "C1839259#ent", "<e2>", "=", "10(-6", ")", "M", ")", "."], "h": {"id": "C0041345", "name": "C0041345#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", "we", "have", "investigated", "the", "expression", "and", "subcellular", "distribution", "of", "C1826384#ent", "<e1>", ",", "the", "human", "C1334043#ent", "<e2>", "of", "XCAP-H", ",", "in", "order", "to", "better", "understand", "its", "cellular", "functions"], "h": {"id": "C1826384", "name": "C1826384#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}}
{"token": ["A", "variety", "of", "further", "manifestations", "are", "associated", "with", "infection", "such", "as", "arthralgias", ",", "C0003864#ent", "<e1>", ",", "leukopenia", "and", "C1839163#ent", "<e2>", ",", "anemia", "and", "vasculitis", ",", "spontaneous", "abortion", "hydrops", "fetalis", "pregnant", "women"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [18, 19]}}
{"token": ["Because", "of", "the", "essential", "roles", "of", "C0050795#ent", "<e1>", "living", "cells", "inhibitors", "of", "C0050795#ent", "<e1>", "expected", "to", "be", "C0003207#ent", "<e1>", "especially", "for", "viruses", "and", "malaria", "parasite", "."], "h": {"id": "C0050795", "name": "C0050795#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003207", "name": "C0003207#ent", "pos": [17, 18]}}
{"token": ["These", "electrical", "events", "recorded", "at", "C0240940#ent", "<e1>", "locations", "Fz", ",", "F8", ",", "F7", ",", "C1413014#ent", "<e2>", ",", "C5", ",", "referred", "either", "to", "Cv7", "(", "seventh", "cervical", "vertebra", "or", "to", "Fz", "."], "h": {"id": "C0240940", "name": "C0240940#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413014", "name": "C1413014#ent", "pos": [14, 15]}}
{"token": ["In", "the", "colitis-associated", "colon", "cancer", "CAC", ")", "model", ",", "we", "induced", "colonic", "tumors", "C57/BL6", "mice", "by", "azoxymethane", "and", "C0079224#ent", "<e1>", "administration", ",", "and", "evaluated", "C0074554#ent", "<e2>", "on", "tumor", "growth"], "h": {"id": "C0079224", "name": "C0079224#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0074554", "name": "C0074554#ent", "pos": [24, 25]}}
{"token": ["Production", "of", "C0253464#ent", "<e1>", "and", "SPI-2", ",", "which", "was", "C0669365#ent", "<e2>", "in", "the", "normal", "animal", "could", "be", "abolished", "by", "hypophysectomy", "and", "was", "strongly", "decreased", "during", "acute", "inflammation"], "h": {"id": "C0253464", "name": "C0253464#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [9, 10]}}
{"token": ["We", "investigated", "the", "effects", "of", "negative", "costimulatory", "receptor", "cytotoxic", "T-lymphocyte", "antigen-4", "C1705969#ent", "<e1>", ")", "on", "GATA-3", "and", "C1420610#ent", "<e2>", "mRNA", "expression", "and", "Th", "cell", "differentiation", "in", "mouse", "naive", "CD4+", "T", "cells"], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [17, 18]}}
{"token": ["Here", ",", "we", "examined", "the", "regulation", "of", "C1705969#ent", "<e1>", "expression", "by", "Th-specific", "transcription", "factors", "C1420610#ent", "<e2>", "and", "GATA-3", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [14, 15]}}
{"token": ["At", "variance", ",", "C1705969#ent", "<e1>", "does", "not", "affect", "C1420610#ent", "<e2>", "mRNA", "expression", "and", "Th1", "cell", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [8, 9]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "investigate", "the", "effect", "of", "the", "nucleoside", "analogue", "treatment", "on", "C0042749#ent", "<e1>", "CD4+", "cell", "count", "disease", "progression", "patients", "with", "and", "without", "syncytium-inducing", "(", "C1420066#ent", "<e2>", ")", "HIV-1", "variants", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [30, 31]}}
{"token": ["C3658209#ent", "<e1>", "attenuated", "prostaglandin", "synthesis", "but", "C0597220#ent", "<e2>", "no", "effect"], "h": {"id": "C3658209", "name": "C3658209#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597220", "name": "C0597220#ent", "pos": [6, 7]}}
{"token": ["The", "nonreducing", "termini", "of", "C1706236#ent", "<e1>", "from", "Mycobacterium", "leprae", "also", "found", "to", "be", "capped", "with", "C1257960#ent", "<e2>", "but", "at", "a", "significantly", "lower", "level", "."], "h": {"id": "C1706236", "name": "C1706236#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1257960", "name": "C1257960#ent", "pos": [15, 16]}}
{"token": ["Sensitized", "T", "cells", "in", "both", "lymphocytic", "choriomeningitis", "LCM", ")", "and", "C0275686#ent", "<e1>", "are", "apparently", "unaffected", "by", "treatment", "of", "mice", "with", "C0063077#ent", "<e2>"], "h": {"id": "C0275686", "name": "C0275686#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0063077", "name": "C0063077#ent", "pos": [20, 21]}}
{"token": ["In", "inflammatory", "bowel", "disease", "C1413976#ent", "<e1>", "is", "expressed", "in", "metaplastic", "Paneth", "cells", "the", "colon", ",", "and", "C1416679#ent", "<e2>", "is", "expressed", "by", "some", "surface", "epithelial", "cells"], "h": {"id": "C1413976", "name": "C1413976#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416679", "name": "C1416679#ent", "pos": [16, 17]}}
{"token": ["i", ")", "Electrophoretic", "profiles", "of", "CMV", "C1305923#ent", "<e1>", "immune-precipitated", "by", "sera", "from", "children", "with", "perinatal", "and", "C0275544#ent", "<e2>", "similar", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0275544", "name": "C0275544#ent", "pos": [16, 17]}}
{"token": ["Sera", "obtained", "serially", "from", "symptomatic", "children", "for", "years", "after", "birth", "continued", "to", "precipitate", "CMV", "C1305923#ent", "<e1>", ",", "whereas", "sera", "from", "children", "with", "C0275544#ent", "<e2>", "lesser", "amounts", "time", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0275544", "name": "C0275544#ent", "pos": [22, 23]}}
{"token": ["The", "C1254351#ent", "<e1>", "was", "able", "to", "enhance", "the", "DTH-response", "against", "C3891070#ent", "<e2>", "and", "to", "stimulate", "the", "humoral", "immune", "response", "Tetanus", "toxoid", "heat-killed", "E.", "coli", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3891070", "name": "C3891070#ent", "pos": [10, 11]}}
{"token": ["Phylogenies", "based", "on", "distances", "and", "parsimony", "analysis", "show", "that", "all", "plant", "C0007367#ent", "<e1>", "derive", "from", "a", "common", "C1413138#ent", "<e2>", "can", "be", "divided", "into", "three", "distinct", "groups", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [17, 18]}}
{"token": ["We", "have", "developed", "degenerated", "primers", "for", "the", "isolation", "of", "several", "fungal", "species", "C0007367#ent", "<e1>", ",", "based", "on", "the", "known", "C1413138#ent", "<e2>", "several", "yeast", "species"], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [19, 20]}}
{"token": ["In", "C0035457#ent", "<e1>", "methacholine", "responsiveness", "correlated", "with", "the", "severity", "of", "daily", "C0231918#ent", "<e2>", "those", "provoked", "by", "specific", "allergen", "challenge", "tests"], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0231918", "name": "C0231918#ent", "pos": [11, 12]}}
{"token": ["The", "minimum", "region", "overlap", "of", "these", "deletions", ",", "located", "between", "the", "interferon", "genes", "the", "methylthioadenosine", "phosphorylase", "gene", "is", "partially", "C1419895#ent", "<e1>", "with", "a", "region", "of", "mouse", "chromosome", "4", "has", "C0079427#ent", "<e2>"], "h": {"id": "C1419895", "name": "C1419895#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [29, 30]}}
{"token": ["This", "study", "examines", "the", "effects", "of", "blockade", "by", "nifedipine", "on", "C2699403#ent", "<e1>", "and", "alpha-2", "adrenoceptor-mediated", "contractile", "responses", "the", "human", "isolated", "digital", "artery", "exogenous", "C0243192#ent", "<e2>", "and", "sympathetic", "nerve", "stimulation", "."], "h": {"id": "C2699403", "name": "C2699403#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [23, 24]}}
{"token": ["3", ")", "Noradrenergic", "agonism", "both", "C2699403#ent", "<e1>", "and", "alpha-2", "receptors", "but", "these", "C0243192#ent", "<e2>", "may", "interfere", "with", "haloperidol-", "and", "reserpine-induced", "catalepsy", ")", "."], "h": {"id": "C2699403", "name": "C2699403#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}}
{"token": ["Since", "ingestion", "of", "foods", "that", "are", "high", "in", "fat", "and", "sugar", "is", "associated", "with", "increased", "incidence", "of", "C0011849#ent", "<e1>", ",", "we", "examined", "if", "C0043119#ent", "<e2>", "mutations", "might", "affect", "metabolic", "response", "a", "diabetogenic", "diet"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C0043119", "name": "C0043119#ent", "pos": [23, 24]}}
{"token": ["Computer", "modeling", "used", "to", "design", "a", "dimeric", "zinc", "finger", "protein", "ZFGD1", ",", "containing", "zinc", "fingers", "1", "2", "from", "C1414314#ent", "<e1>", "and", "a", "portion", "of", "the", "dimerization", "domain", "C3541252#ent", "<e2>", "."], "h": {"id": "C1414314", "name": "C1414314#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3541252", "name": "C3541252#ent", "pos": [27, 28]}}
{"token": ["The", "levels", "of", "C1418929#ent", "<e1>", "or", "-Ibeta", "expression", "were", "comparable", "to", "endogenous", "C3489929#ent", "<e2>", "expression", "in", "wild-type", "aortic", "and", "intestinal", "smooth", "muscles"], "h": {"id": "C1418929", "name": "C1418929#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3489929", "name": "C3489929#ent", "pos": [12, 13]}}
{"token": ["Pentobarbital", ",", "diazepam", "and", "clonazepam", "attenuated", "the", "normeperidine-induced", "suppression", "of", "behavior", ",", "whereas", "C0002569#ent", "<e1>", "baclofen", "and", "ethanol", "failed", "to", "attenuate", "the", "effects", "of", "C0025376#ent", "<e2>", "."], "h": {"id": "C0002569", "name": "C0002569#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025376", "name": "C0025376#ent", "pos": [24, 25]}}
{"token": ["We", "have", "generated", "an", "alloreactive", "proliferative", "T", "cell", "clone", "that", "only", "is", "stimulated", "by", "HLA-DPw3", "+", "antigen", "presenting", "cells", "(", "C3540812#ent", "<e1>", ")", "that", "at", "the", "same", "time", "carry", "C1881019#ent", "<e2>", "."], "h": {"id": "C3540812", "name": "C3540812#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1881019", "name": "C1881019#ent", "pos": [29, 30]}}
{"token": ["Here", "we", "have", "investigated", "the", "mechanism", "of", "regulation", "of", "choline", "kinase", "C0242853#ent", "<e1>", "found", "no", "direct", "link", "between", "PLD", "and", "C0008415#ent", "<e2>"], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008415", "name": "C0008415#ent", "pos": [20, 21]}}
{"token": ["To", "determine", "CYP2C19", "and", "C3887685#ent", "<e1>", "patients", "with", "C0026769#ent", "<e2>", "MS", ")", "before", "and", "during", "interferon", "(IFN)-beta", "treatment", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [8, 9]}}
{"token": ["For", "G", "protein-coupled", "receptors", "C1367690#ent", "<e1>", ")", ",", "conflicting", "data", "suggest", "that", "these", "receptors", "stimulate", "C0164786#ent", "<e2>", "in", "a", "cell", "type-specific", "manner", "by", "a", "yet", "to", "be", "fully", "elucidated", "mechanism", "."], "h": {"id": "C1367690", "name": "C1367690#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [15, 16]}}
{"token": ["We", "also", "show", "that", "not", "only", "mouse", "C1704918#ent", "<e1>", "but", "also", "Drosophila", "Notch", "RAMIC", "interacts", "with", "mouse", "C3887789#ent", "<e2>", "and", "GCN5", "in", "mammalian", "cells"], "h": {"id": "C1704918", "name": "C1704918#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3887789", "name": "C3887789#ent", "pos": [17, 18]}}
{"token": ["The", "present", "study", "reveals", "that", "melanotrope", "cells", "of", "the", "C0032002#ent", "<e1>", "express", "the", "PSS2", "gene", "and", "fully", "process", "C1456391#ent", "<e2>", "to", "generate", "the", "mature", "somatostatin", "variant", "SS2", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1456391", "name": "C1456391#ent", "pos": [18, 19]}}
{"token": ["I", "treated", "seven", "patients", "with", "keratomycosis", "(", "four", "with", "Candida", "infections", "three", "with", "C0004030#ent", "<e1>", "with", "topical", "and", "subconjunctival", "C0025942#ent", "<e2>", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [19, 20]}}
{"token": ["Bilateral", "electrolytic", "lesions", "of", "ABL", "or", "C0026850#ent", "<e1>", "produced", "a", "parallel", "transient", "decrease", "of", "SS", "and", "C0026847#ent", "<e2>", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [16, 17]}}
{"token": ["The", "evidence", "suggests", "a", "C0026850#ent", "<e1>", "than", "polymyositis", ",", "although", "a", "hereditary", "form", "of", "C0026847#ent", "<e2>", "not", "be", "excluded", "entirely", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [14, 15]}}
{"token": ["Neurocysticercosis", "(", "NC", ")", "is", "a", "chronic", "parasitary", "disease", "may", "have", "different", "neurological", "manifestations", "such", "as", "C0751495#ent", "<e1>", ",", "dementia", "or", "C0549423#ent", "<e2>"], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0549423", "name": "C0549423#ent", "pos": [21, 22]}}
{"token": ["The", "major", "presenting", "symptom", "is", "C0751495#ent", "<e1>", ",", "although", "symptoms", "of", "C0549423#ent", "<e2>", "if", "cysts", "are", "located", "near", "the", "ventricles", "or", "in", "the", "subarachnoid", "spaces", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0549423", "name": "C0549423#ent", "pos": [11, 12]}}
{"token": ["The", "role", "of", "C1412501#ent", "<e1>", "(", "Apoptosis", "Repressor", "with", "C0010656#ent", "<e2>", "Recruitment", "Domain", ")", "in", "PC12", "cell", "withdrawal", "driven", "apoptosis", "was", "studied", "."], "h": {"id": "C1412501", "name": "C1412501#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [9, 10]}}
{"token": ["It", "is", "concluded", "that", "the", "inhibition", "of", "microsomal", "lipid", "peroxidation", "in", "vitro", "the", "consecutive", "action", "of", "C0031667#ent", "<e1>", "which", "releases", "fatty", "acyl", "hydroperoxides", "peroxidized", "phospholipids", "and", "GSH", "C0027021#ent", "<e2>", ",", "which", "reduce", "them", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [27, 28]}}
{"token": ["In", "the", "zymosan-injected", "rat", "air", "pouch", "ircinin", "inhibited", "in", "vivo", "activity", "of", "C0031667#ent", "<e1>", "present", "in", "exudates", "and", "reduced", "dose-dependently", "C0027021#ent", "<e2>", "whereas", "cell", "migration", "inhibited", "only", "at", "the", "highest", "dose", "tested", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [20, 21]}}
{"token": ["The", "mechanisms", "by", "which", "arginine-", "and", "histidine-rich", "polyelectrolytes", "activate", "the", "respiratory", "burst", "neutrophils", "might", "involve", "interaction", "with", "G-proteins", ",", "the", "activation", "of", "arachidonic", "acid", "and", "C0031667#ent", "<e1>", "or", "the", "interaction", "with", "C0027021#ent", "<e2>", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [31, 32]}}
{"token": ["In", "aqueous", "humour", "the", "increase", "in", "C0031667#ent", "<e1>", "and", "proteins", "as", "well", "as", "C0027021#ent", "<e2>", "measured", "from", "iris-ciliary", "blocks", "correlated", "well", "with", "the", "severity", "of", "uveitis", "evaluated", "by", "clinical", "grading"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [13, 14]}}
{"token": ["C0521616#ent", "<e1>", "is", "a", "photosensitive", "C0085932#ent", "<e2>", "is", "distinguished", "from", "porphyria", "cutanea", "tarda", "PCT", ")", "by", "its", "normal", "porphyrin", "profile"], "h": {"id": "C0521616", "name": "C0521616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085932", "name": "C0085932#ent", "pos": [5, 6]}}
{"token": ["In", "the", "frog", "sciatic", "nerves", "we", "found", "that", "C0733682#ent", "<e1>", "could", "significantly", "inhibit", "influx", "of", "C1413043#ent", "<e2>", "+", "."], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [15, 16]}}
{"token": ["Mammalian", "expression", "vectors", "wild-type", "C1413930#ent", "<e1>", "and", "C1413930#ent", "<e1>", "with", "deletions", "in", "the", "C0030956#ent", "<e1>", "were", "used", "to", "transform", "COS", "and", "CHO", "cells"], "h": {"id": "C1413930", "name": "C1413930#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [13, 14]}}
{"token": ["Peptide", "analysis", "trypsin", "treated", "C1413930#ent", "<e1>", "shows", "at", "least", "three", "C0030956#ent", "<e2>", "with", "the", "same", "electrophoretic", "mobility"], "h": {"id": "C1413930", "name": "C1413930#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}}
{"token": ["A", "yeast", "two-hybrid", "screen", "alpha-synuclein", "(", "alpha-syn", ")", "identified", "synphilin", "as", "an", "C3541909#ent", "<e1>", "potentially", "implicating", "C1420277#ent", "<e2>", "in", "the", "pathogenesis", "of", "synucleinopathies", "."], "h": {"id": "C3541909", "name": "C3541909#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420277", "name": "C1420277#ent", "pos": [16, 17]}}
{"token": ["The", "two", "transcripts", "encoding", "C3541909#ent", "<e1>", "and", "synphilin-1", "originate", "from", "the", "C1420277#ent", "<e2>", "differ", "in", "both", "their", "exon", "organization", "initial", "reading", "frames", "for", "translation", "."], "h": {"id": "C3541909", "name": "C3541909#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420277", "name": "C1420277#ent", "pos": [11, 12]}}
{"token": ["We", "identified", "a", "novel", "interacting", "protein", "which", "we", "term", "C3541909#ent", "<e1>", "(", "encoded", "by", "the", "C1420277#ent", "<e2>", "."], "h": {"id": "C3541909", "name": "C3541909#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420277", "name": "C1420277#ent", "pos": [15, 16]}}
{"token": ["In", "eWAT", "obtained", "from", "NCAD", "or", "C0010068#ent", "<e1>", "patients", ",", "immunoreactivity", "for", "AM", ",", "CRLR", ",", "and", "C1416790#ent", "<e2>", "and", "-3", "was", "detected", "in", "blood", "vessel", "walls", "isolated", "stromal", "cells", "to", "adipocytes", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416790", "name": "C1416790#ent", "pos": [17, 18]}}
{"token": ["C0040558#ent", "<e1>", "has", "five", "clinical", "subtypes", "lymphadenopathy", ",", "encephalitis", ",", "chorioretinitis", ",", "C0343816#ent", "<e2>", "congenital", "toxoplasmosis"], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0343816", "name": "C0343816#ent", "pos": [12, 13]}}
{"token": ["We", "applied", "a", "dot", "blot", "hybridization", "assay", "blood", "samples", "the", "diagnosis", "of", "C0040558#ent", "<e1>", "CT", ")", ",", "acute", "toxoplasmic", "lymphadenopathy", "ATL", ")", ",", "and", "C0343816#ent", "<e2>", "transplant", "recipients", "TRs", ")", "."], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0343816", "name": "C0343816#ent", "pos": [24, 25]}}
{"token": ["C1707080#ent", "<e1>", "inhibits", "the", "mammalian", "target", "of", "rapamycin", "(", "C1307407#ent", "<e2>", ")", "."], "h": {"id": "C1707080", "name": "C1707080#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C1307407", "name": "C1307407#ent", "pos": [9, 10]}}
{"token": ["We", "had", "previously", "reported", "that", "hypoxia-induced", "C1336623#ent", "<e1>", "mRNA", "expression", "in", "lymphatic", "endothelial", "cells", "C1418643#ent", "<e2>", ")", "."], "h": {"id": "C1336623", "name": "C1336623#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418643", "name": "C1418643#ent", "pos": [14, 15]}}
{"token": ["Hypertensive", "patients", "and", "those", "maintained", "on", "insulin", "showed", "a", "greater", "predisposition", "to", "C0151744#ent", "<e1>", "IHD", ")", "than", "did", "non-hypertensives", "and", "patients", "maintained", "on", "C0020616#ent", "<e2>", "respectively", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [23, 24]}}
{"token": ["We", "report", "the", "case", "of", "a", "81-year-old", "man", "with", "insulin-dependent", "diabetes", "mellitus", "showed", "electrocardiographic", "features", "C0151744#ent", "<e1>", "an", "episode", "of", "C0020616#ent", "<e2>", ";", "these", "alterations", "disappeared", "after", "glucose", "administration"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [20, 21]}}
{"token": ["The", "NOS", "diffuses", "to", "the", "LHRH", "terminal", "and", "activates", "C0671566#ent", "<e1>", "GC", ")", ",", "cyclooxygenase", "and", "C0023835#ent", "<e2>", "causing", "release", "of", "LHRH", "via", "release", "of", "cyclic", "GMP", "PGE2", "and", "leukotrienes", ",", "respectively", "."], "h": {"id": "C0671566", "name": "C0671566#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023835", "name": "C0023835#ent", "pos": [16, 17]}}
{"token": ["C0024518#ent", "<e1>", "MHC", ")", "TL", "region", "and", "thymic", "shared", "antigen", "C1334353#ent", "<e2>", ")", "gene", "expression", "increased", ",", "suggesting", "T", "cell", "activation", "in", "the", "hippocampus", "with", "age", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334353", "name": "C1334353#ent", "pos": [10, 11]}}
{"token": ["In", "wild-type", "mouse", "blood", "vessels", "C2936882#ent", "<e1>", "attenuates", "vasoconstriction", "by", "an", "ERbeta-mediated", "increase", "in", "C1533698#ent", "<e2>", "expression", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [14, 15]}}
{"token": ["In", "4-mo-old", "rats", ",", "C2936882#ent", "<e1>", "also", "significantly", "suppressed", "LPS", "induction", "of", "C1533698#ent", "<e2>", "cyclooxygenase-2", "proteins", "as", "well", "as", "production", "of", "nitric", "oxide", "PGE(2", ")", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [12, 13]}}
{"token": ["On", "C0037506#ent", "<e1>", "gels", ",", "the", "purified", "C0026741#ent", "<e2>", "separated", "into", "five", "polypeptides", "."], "h": {"id": "C0037506", "name": "C0037506#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [7, 8]}}
{"token": ["Deferasirox", "--", "an", "oral", "iron", "chelator", "could", "be", "an", "effective", "treatment", "against", "porphyria", "cutanea", "tarda", "C1384665#ent", "<e1>", ",", "and", "pathogens", "such", "as", "mucor", "that", "C2938208#ent", "<e2>", "in", "iron", "rich", "environments"], "h": {"id": "C1384665", "name": "C1384665#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2938208", "name": "C2938208#ent", "pos": [24, 25]}}
{"token": ["It", "suggests", "that", "erythromycin", "might", "have", "an", "C0243192#ent", "<e1>", "action", "on", "the", "motilin", "receptor", "an", "C0243192#ent", "<e1>", "action", "on", "the", "motilin", "receptor", "an", "exogenously", "administrated", "C1417190#ent", "<e1>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417190", "name": "C1417190#ent", "pos": [25, 26]}}
{"token": ["Timed", "treatment", "pregnant", "LTalpha-/-", "mice", "with", "an", "C0243192#ent", "<e1>", "anti-LTbetaR", "mAb", "induces", "formation", "of", "C1417190#ent", "<e2>", "but", "not", "of", "PP", "in", "LTalpha-/-", "mice", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417190", "name": "C1417190#ent", "pos": [14, 15]}}
{"token": ["Normalization", "of", "C0812281#ent", "<e1>", "production", "and", "platelet", "aggregation", "C0965129#ent", "<e2>", "indicates", "its", "potential", "use", "as", "a", "vasculoprotective", "agent"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0965129", "name": "C0965129#ent", "pos": [8, 9]}}
{"token": ["H2O2", "C0001622#ent", "<e1>", "can", "cause", "inactivation", "of", "C1413138#ent", "<e2>", "as", "well", "as", "vacuolation", "in", "epidermal", "melanocytes", "and", "keratinocytes", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [7, 8]}}
{"token": ["It", "was", "subsequently", "used", "as", "a", "host", "for", "C0001622#ent", "<e1>", "of", "two", "endogenous", "peroxisomal", "matrix", "proteins", "amine", "oxidase", "C1413138#ent", "<e2>", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [18, 19]}}
{"token": ["Correlation", "between", "plasma", "and", "CSF", "C2936886#ent", "<e1>", "and", "magnesium", "concentrations", "indicated", "that", "C4048158#ent", "<e2>", "occurred", "when", "CSF", "magnesium", "and", "plasma", "calcium", "concentrations", "declined", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [12, 13]}}
{"token": ["There", "was", "100", "%", "correlation", "between", "localized", "adherence", "(", "C1420423#ent", "<e1>", ")", "to", "HEp-2", "cells", "and", "the", "C1539477#ent", "<e2>"], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [17, 18]}}
{"token": ["It", "shows", "similarity", "to", "the", "Saccharomyces", "cerevisiae", "gene", "product", "and", "the", "gp91-phox", "protein", "a", "component", "of", "the", "human", "NADPH", "C0030016#ent", "<e1>", "is", "deficient", "in", "C1844376#ent", "<e2>"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1844376", "name": "C1844376#ent", "pos": [24, 25]}}
{"token": ["Three", "of", "the", "four", "C0030956#ent", "<e1>", "from", "both", "C3540017#ent", "<e2>", "were", "sequenced", "and", "all", "the", "tryptic", "peptides", "both", "C3540017#ent", "<e2>", "were", "characterized", "by", "amino", "acid", "analysis"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [8, 9]}}
{"token": ["We", "report", "these", "cases", "to", "draw", "attention", "to", "an", "unusual", "pattern", "of", "C0017925#ent", "<e1>", "can", "simulate", "C0017925#ent", "<e1>"], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0017925", "name": "C0017925#ent", "pos": [12, 13]}}
{"token": ["The", "eruption", "usually", "occurs", "in", "individuals", "with", "atopic", "dermatitis", "other", "pre-existing", "dermatosis", "such", "as", "C0017925#ent", "<e1>", "pemphigus", "foliaceus", "mycosis", "fungoides", "Sezary", "syndrome", "benign", "familial", "pemphigus", "ichthyosis", "vulgaris", "second-degree", "burns", "multiple", "myeloma", "and", "C0017925#ent", "<e1>"], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0017925", "name": "C0017925#ent", "pos": [14, 15]}}
{"token": ["Human", "C0017925#ent", "<e1>", "also", "known", "as", "glycogen", "storage", "disease", "type", "VI", "GSD", "VI", "or", "C0017925#ent", "<e1>", "is", "characterized", "by", "hepatomegaly", "and", "reduced", "or", "absent", "glycogenolytic", "response", "to", "the", "injection", "of", "glucagon", "."], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0017925", "name": "C0017925#ent", "pos": [1, 2]}}
{"token": ["Three", "of", "these", "patients", "had", "a", "C0021847#ent", "<e1>", "with", "or", "without", "ataxia", "in", "addition", "to", "the", "C0206157#ent", "<e2>", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0206157", "name": "C0206157#ent", "pos": [16, 17]}}
{"token": ["CD3", ",", "CD4", ",", "CD8", ",", "CD19", ",", "C1414556#ent", "<e1>", ",", "CD10", ",", "SIg", "positive", "cells", "quantified", "in", "bone", "marrow", "peripheral", "blood", "35", "C1332015#ent", "<e2>", "patients", "."], "h": {"id": "C1414556", "name": "C1414556#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332015", "name": "C1332015#ent", "pos": [23, 24]}}
{"token": ["Protein-protein", "interaction", "analyses", "uncovered", "a", "ciliary", "and", "basal", "body", "protein", "network", "that", ",", "when", "disrupted", ",", "can", "result", "in", "nephronophthisis", "(", "NPHP", ")", ",", "Leber", "congenital", "amaurosis", "C0403553#ent", "<e1>", "SLSN", ")", "or", "Joubert", "syndrome", "C0431399#ent", "<e2>", ")", "."], "h": {"id": "C0403553", "name": "C0403553#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0431399", "name": "C0431399#ent", "pos": [34, 35]}}
{"token": ["Protein-protein", "interaction", "analyses", "uncovered", "a", "ciliary", "and", "basal", "body", "protein", "network", "that", ",", "when", "disrupted", ",", "can", "result", "in", "nephronophthisis", "(", "NPHP", ")", ",", "Leber", "congenital", "amaurosis", "C0403553#ent", "<e1>", "SLSN", ")", "or", "C0431399#ent", "<e2>", "JBTS", ")", "."], "h": {"id": "C0403553", "name": "C0403553#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0431399", "name": "C0431399#ent", "pos": [32, 33]}}
{"token": ["C2937288#ent", "<e1>", "selectively", "regulated", "the", "translation", "of", "specific", "C0017337#ent", "<e2>", "including", "histone", "4", "HMG2", "in", "germ", "cells"], "h": {"id": "C2937288", "name": "C2937288#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "strong", "neocortical", "C0907533#ent", "<e1>", "expression", "of", "C1414314#ent", "<e2>", "was", "almost", "abolished", "by", "MK-801", "administration", ",", "and", "replaced", "by", "an", "expression", "pattern", "similar", "to", "that", "of", "FOS", "and", "JUN", "proteins"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414314", "name": "C1414314#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "despite", "the", "development", "of", "large", "granular", "morphology", "during", "proliferation", ",", "interleukin-2", "cultured", "C1334863#ent", "<e1>", "HDLs", "display", "a", "different", "pattern", "of", "C1333877#ent", "<e2>", "expression", "from", "C1334863#ent", "<e1>", "LGLs", "."], "h": {"id": "C1333877", "name": "C1333877#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [14, 15]}}
{"token": ["The", "time", "course", "concentration-effect", "relationship", "of", "C0030511#ent", "<e1>", "effects", "of", "three", "C0242893#ent", "<e2>", "investigated", "using", "spectral", "analysis", "heart", "rate", "HR", ")", "variability", "."], "h": {"id": "C0030511", "name": "C0030511#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [11, 12]}}
{"token": ["This", "enhanced", "C0662902#ent", "<e1>", "activation", "is", "coupled", "with", "increased", "RACK1", "expression", "and", "C0257292#ent", "<e2>", "interactions", ",", "demonstrating", "PKC", "epsilon-induced", "C0662902#ent", "<e1>", "via", "a", "RACK1-dependent", "mechanism", "."], "h": {"id": "C0662902", "name": "C0662902#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0257292", "name": "C0257292#ent", "pos": [12, 13]}}
{"token": ["IgG-antibodies", "from", "heterologous", "serum", "samples", "elicited", "a", "number", "of", "false", "positives", "25/147", ")", "from", "six", "different", "helminthic", "infections", "ie", "C0030424#ent", "<e1>", ",", "echinococcosis", ",", "opisthorchiasis", ",", "ascariasis", ",", "taeniasis", "and", "C0015652#ent", "<e2>", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0015652", "name": "C0015652#ent", "pos": [30, 31]}}
{"token": ["Serum", "samples", "(", "n18", ")", "from", "patients", "presenting", "other", "parasite", "infections", "C0030424#ent", "<e1>", ",", "cysticercosis", ",", "and", "C0015652#ent", "<e2>", ")", "or", "healthy", "blood", "donors", "n15", ")", ",", "were", "designated", "as", "control", "groups"], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015652", "name": "C0015652#ent", "pos": [17, 18]}}
{"token": ["This", "study", "demonstrates", "that", "our", "sandwich", "ELISA", "for", "the", "detection", "of", "Fasciola", "coproantigens", "is", "able", "to", "detect", "immature", "C0030424#ent", "<e1>", "more", "importantly", ",", "was", "able", "to", "detect", "patent", "infection", "C0015652#ent", "<e2>", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0015652", "name": "C0015652#ent", "pos": [29, 30]}}
{"token": ["Round", "window", "atresia", "can", "be", "seen", "in", "association", "with", "syndromal", "anomalies", "as", "mandibulofacial", "dysostosis", "Mondini", "type", "anomalies", "or", "C0010308#ent", "<e1>", ",", "or", "with", "extensive", "C0029899#ent", "<e2>", "."], "h": {"id": "C0010308", "name": "C0010308#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0029899", "name": "C0029899#ent", "pos": [24, 25]}}
{"token": ["The", "first", "example", "of", "dual", "inhibitors", "C0127082#ent", "<e1>", "MMP", ")", "and", "C0054868#ent", "<e2>", "is", "described", "."], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054868", "name": "C0054868#ent", "pos": [11, 12]}}
{"token": ["In", "addition", "to", "the", "C0127082#ent", "<e1>", "MMP", ")", "and", "C0054868#ent", "<e2>", "mediated", "collagen", "degradation", "pathways", "a", "serine", "proteinase", "pathway", "has", "recently", "been", "identified", "in", "TMJ", "fibroblasts", "."], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054868", "name": "C0054868#ent", "pos": [9, 10]}}
{"token": ["The", "basal", "phosphorylation", "of", "Akt", "and", "C4283740#ent", "<e1>", "and", "the", "activity", "of", "C0031686#ent", "<e2>", "PP1", ")", "were", "comparable", "between", "fasted", "and", "fed", "control", "rats", "."], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [12, 13]}}
{"token": ["Carbofuran", "is", "a", "C0041964#ent", "<e1>", "that", "functions", "as", "a", "C0008425#ent", "<e2>"], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [9, 10]}}
{"token": ["Brains", "from", "rats", "treated", "either", "with", "a", "C0041964#ent", "<e1>", "or", "an", "organophosphate", "C0008425#ent", "<e2>", "pesticide", "showed", "significant", "regional", "variation", "in", "cholinesterase", "inhibition", "."], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [12, 13]}}
{"token": ["The", "pesticides", "used", "in", "this", "study", "included", "C0041964#ent", "<e1>", "and", "organophosphates", ",", "which", "acts", "as", "reversible", "and", "irreversible", "C0008425#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [18, 19]}}
{"token": ["Our", "findings", "reveal", "exceptionally", "high", "resistance", "of", "Xenopus", "AChE", "C0041964#ent", "<e1>", ",", "organophosphate", "and", "C0008425#ent", "<e2>"], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [14, 15]}}
{"token": ["In", "the", "subconfluent", "state", ",", "C1515406#ent", "<e1>", "basic", "fibroblast", "growth", "factor", "insulin-like", "growth", "factor-II", "and", "fetal", "calf", "serum", "markedly", "upregulated", "C1334507#ent", "<e2>", "mRNA", "expression", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334507", "name": "C1334507#ent", "pos": [20, 21]}}
{"token": ["To", "clarify", "the", "effect", "of", "C1336666#ent", "<e1>", "in", "development", ",", "we", "previously", "identified", "a", "TRAF-interacting", "protein", "a", "forkhead-associated", "domain", "C1423038#ent", "<e2>", ")", ",", "which", "binds", "and", "activates", "C1336666#ent", "<e1>", "upon", "extracellular", "stimulation"], "h": {"id": "C1423038", "name": "C1423038#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1336666", "name": "C1336666#ent", "pos": [5, 6]}}
{"token": ["Importantly", ",", "C1423038#ent", "<e1>", "induces", "the", "oligomerization", "and", "polyubiquitination", "of", "C1336666#ent", "<e2>", ",", "which", "leads", "to", "the", "activation", "of", "TAK1", "and", "IKK", "through", "a", "proteasome-independent", "mechanism", "."], "h": {"id": "C1423038", "name": "C1423038#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336666", "name": "C1336666#ent", "pos": [10, 11]}}
{"token": ["These", "results", "indicate", "an", "interrelationship", "between", "C1415484#ent", "<e1>", "production", "of", "C3273436#ent", "<e2>", "and", "prostanoids", ",", "which", "may", "play", "a", "role", "in", "regulating", "cerebral", "microcirculation"], "h": {"id": "C1415484", "name": "C1415484#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [10, 11]}}
{"token": ["Transfusion", "or", "erythropoietic", "agents", "e.g.", ",", "C0357126#ent", "<e1>", "epoetin", "beta", "darbepoetin", "alfa", "are", "used", "for", "anemia", "of", "C1561643#ent", "<e2>", "their", "treatments", "(", "e.g.", ",", "cancer/chemotherapy", "and", "chronic", "kidney", "disease", "."], "h": {"id": "C0357126", "name": "C0357126#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [17, 18]}}
{"token": ["Inhibition", "of", "C1412756#ent", "<e1>", "decreased", "evoked", "C0242287#ent", "<e2>", "ACh", "release", "in", "AChE-KO", "NMJs", "."], "h": {"id": "C1412756", "name": "C1412756#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242287", "name": "C0242287#ent", "pos": [6, 7]}}
{"token": ["We", "report", "the", "case", "of", "a", "51-year-old", "woman", "who", "presented", "with", "bilateral", "progressive", "deterioration", "in", "vision", "after", "taking", "C0008269#ent", "<e1>", "for", "severe", "C0003873#ent", "<e2>", "10", "years", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [22, 23]}}
{"token": ["C0008269#ent", "<e1>", "is", "one", "of", "the", "antimalaria", "drugs", "also", "used", "to", "treat", "C0003873#ent", "<e2>", "systemic", "lupus", "erythematosus", "SLE", ")", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}}
{"token": ["This", "study", "compares", "the", "effect", "of", "azathioprine", "with", "those", "of", "gold", "and", "C0008269#ent", "<e1>", "in", "early", "(", "Class", "II", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}}
{"token": ["The", "car", "gene", "cluster", "the", "ascomycete", "Fusarium", "fujikuroi", "encodes", "two", "enzymes", "responsible", "for", "torulene", "biosynthesis", "CarRA", "and", "CarB", ")", ",", "an", "opsin-like", "protein", "C1366496#ent", "<e1>", ")", ",", "and", "a", "putative", "carotenoid", "cleaving", "enzyme", "C1425272#ent", "<e2>", ")", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1425272", "name": "C1425272#ent", "pos": [33, 34]}}
{"token": ["A", "combination", "of", "four", "flow", "promoting", "therapeutic", "measures", "heparinisation", ",", "hemodilution", ",", "C0085580#ent", "<e1>", "brainflushing", "with", "C0011806#ent", "<e2>", "40", ")", "greatly", "improves", "recovery", "of", "the", "brain", "function", "12", "min", "."], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011806", "name": "C0011806#ent", "pos": [16, 17]}}
{"token": ["The", "biosynthetic", "process", "a", "tyrosine", "hydroxylase", "a", "C1413943#ent", "<e1>", "is", "independent", "of", "C0041484#ent", "<e2>", "."], "h": {"id": "C1413943", "name": "C1413943#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041484", "name": "C0041484#ent", "pos": [12, 13]}}
{"token": ["Both", "chloroquine", "and", "C0282331#ent", "<e1>", ",", "and", "to", "a", "lesser", "extent", "C0020336#ent", "<e2>", ",", "inhibited", "arachidonate", "release", "and", "eicosanoid", "formation", "induced", "by", "phorbol", "diester"], "h": {"id": "C0282331", "name": "C0282331#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [11, 12]}}
{"token": ["We", "cloned", "an", "Achaearanea", "tepidariorum", "Chelicerata", ",", "Arachnida", ")", "gene", "related", "to", "Drosophila", "twist", "(", "twi", ")", ",", "which", "encodes", "a", "basic", "C3273649#ent", "<e1>", "to", "specify", "mesoderm", "C1539479#ent", "<e2>", "in", "the", "Drosophila", "embryo"], "h": {"id": "C3273649", "name": "C3273649#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [27, 28]}}
{"token": ["In", "this", "control", "various", "inhibitory", "(", "dopamine", ",", "gamma-aminobutyric", "acid", "neuropeptide", "Y", "C3887648#ent", "<e1>", ")", "and", "stimulatory", "(", "C1421143#ent", "<e2>", "corticotropin-releasing", "hormone", "neural", "factors", "are", "involved", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [18, 19]}}
{"token": ["The", "rises", "in", "plasma", "C3887648#ent", "<e1>", "and", "adrenaline", "following", "C1421143#ent", "<e2>", "were", "attenuated", "by", "prior", "ganglion", "blockade", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [9, 10]}}
{"token": ["Both", "genera", "produced", "C0003762#ent", "<e1>", ",", "and", "treatment", "of", "members", "of", "either", "genus", "with", "C0002260#ent", "<e2>", "or", "DFMA", "resulted", "in", "an", "inhibition", "of", "ODC", "activity", "and", "a", "depletion", "of", "cellular", "polyamines"], "h": {"id": "C0003762", "name": "C0003762#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002260", "name": "C0002260#ent", "pos": [14, 15]}}
{"token": ["Raltitrexed", "(", "Tomudex", ")", ",", "a", "novel", "folate-based", "inhibitor", "of", "C0040085#ent", "<e1>", "has", "demonstrated", "anti-tumour", "efficacy", "comparable", "with", "5-fluorouracil", "and", "C2721771#ent", "<e2>", "in", "patients", "with", "advanced", "colorectal", "cancer", "CRC", ")", "."], "h": {"id": "C0040085", "name": "C0040085#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2721771", "name": "C2721771#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "we", "found", "GEFH1", "associated", "with", "C0812235#ent", "<e1>", ",", "and", "DN-GEFH1", "or", "GEFH1's", "RNAi", "suppressed", "the", "LPS-mediated", "C0812235#ent", "<e1>", "activation", "and", "C3810551#ent", "<e1>", "surface", "expression", "."], "h": {"id": "C0812235", "name": "C0812235#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3810551", "name": "C3810551#ent", "pos": [22, 23]}}
{"token": ["Posttreatment", "with", "deferoxamine", "or", "with", "the", "combination", "of", "superoxide", "dismutase", "C1413138#ent", "<e1>", "did", "not", "reestablish", "the", "C0042402#ent", "<e2>", "acetylcholine", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [16, 17]}}
{"token": ["The", "decrease", "in", "C1704793#ent", "<e1>", "response", "to", "C2698414#ent", "<e2>", "was", "still", "observed", "following", "the", "inhibition", "of", "prostaglandin", "synthesis", "indomethacin", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [7, 8]}}
{"token": ["The", "propranolol", "infusion", "enhanced", "the", "stimulatory", "effect", "of", "hypoglycemia", "on", "C1704793#ent", "<e1>", ",", "cortisol", ",", "and", "C2698414#ent", "<e2>", "secretion", "and", "also", "enhanced", "the", "stimulatory", "effect", "of", "CRH", "on", "C1704793#ent", "<e1>", "and", "cortisol", "secretion"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [16, 17]}}
{"token": ["C1704793#ent", "<e1>", "was", "consistently", "elevated", "by", "C2698414#ent", "<e2>", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [6, 7]}}
{"token": ["In", "animals", "on", "a", "diet", "of", "hay", "and", "after", "administration", "of", "40", "g", "of", "propionate", "into", "the", "rumen", ",", "C0267356#ent", "<e1>", "the", "same", "quantity", "of", "C3537171#ent", "<e2>", "a", "similar", "reduction", "of", "food", "intake"], "h": {"id": "C0267356", "name": "C0267356#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3537171", "name": "C3537171#ent", "pos": [25, 26]}}
{"token": ["The", "protective", "capacity", "E2his", "was", "demonstrated", "in", "two", "immunization", "and", "challenge", "experiments", "in", "pigs", "using", "doses", "of", "15", "or", "30", "microg", "of", "the", "C0072522#ent", "<e1>", ",", "emulsified", "in", "C0281643#ent", "<e2>"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0281643", "name": "C0281643#ent", "pos": [28, 29]}}
{"token": ["This", "reduction", "was", "greater", "than", "that", "provided", "by", "immunization", "with", "C0072522#ent", "<e1>", "and", "complete", "C0281643#ent", "<e2>", "these", "experiments", "or", "those", "previously", "reported", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0281643", "name": "C0281643#ent", "pos": [14, 15]}}
{"token": ["The", "major", "nonreduced", "mucus", "glycoproteins", "mucins", ")", "from", "sputa", "of", "C0010674#ent", "<e1>", "CF", ")", "and", "C0004096#ent", "<e2>", "patients", "have", "been", "purified", "to", "electrophoretic", "homogeneity", "and", "subjected", "to", "physical", "and", "chemical", "characterization", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}}
{"token": ["Recent", "evidence", "emphasizes", "the", "role", "of", "the", "C0005683#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0026603#ent", "<e2>", "and", "several", "new", "theories", "may", "help", "explain", "its", "occurrence", "beyond", "the", "traditional", "sensory", "conflict", "theory", "."], "h": {"id": "C0005683", "name": "C0005683#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [13, 14]}}
{"token": ["High", "constitutive", "levels", "of", "IL-18", "may", "contribute", "to", "the", "skewing", "towards", "a", "C3537293#ent", "<e1>", "environment", ",", "which", "is", "apparent", "in", "many", "human", "C3875321#ent", "<e2>"], "h": {"id": "C3537293", "name": "C3537293#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3875321", "name": "C3875321#ent", "pos": [22, 23]}}
{"token": ["Cyclic", "GMP", "phosphodiesterase", "PDE6", ")", "in", "rod", "photoreceptors", "a", "key", "C0014442#ent", "<e1>", "in", "vertebrate", "phototransduction", ",", "consists", "of", "two", "homologous", "catalytic", "subunits", "C3890193#ent", "<e2>", "and", "Pbeta", ")", "and", "two", "identical", "regulatory", "subunits", "(", "Pgammas", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3890193", "name": "C3890193#ent", "pos": [22, 23]}}
{"token": ["This", "is", "the", "first", "reported", "localization", "of", "the", "C1417679#ent", "<e1>", "responsible", "for", "C0013261#ent", "<e2>", "this", "dominant", "form", "of", "hydrocephalus", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013261", "name": "C0013261#ent", "pos": [12, 13]}}
{"token": ["Sequencing", "of", "C0013261#ent", "<e1>", "(", "distantly", "related", "sic", "[", "streptococcal", "inhibitor", "complement", "]", ")", "C1417679#ent", "<e2>", "identified", "two", "novel", "alleles", "and", "revealed", "a", "polymorphism", "for", "C0013261#ent", "<e1>", "similar", "to", "that", "of", "sic", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013261", "name": "C0013261#ent", "pos": [2, 3]}}
{"token": ["The", "effects", "of", "C0010976#ent", "<e1>", "on", "serum", "TNFalpha", "and", "corticosterone", "levels", "and", "on", "muscle", "calcium", "C0006784#ent", "<e2>", "expression", ",", "and", "protein", "breakdown", "studied", "in", "rats", "with", "abdominal", "sepsis", "induced", "by", "cecal", "ligation", "puncture", "."], "h": {"id": "C0010976", "name": "C0010976#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [15, 16]}}
{"token": ["This", "trial", "randomized", "22,576", "hypertensive", "patients", "with", "coronary", "artery", "disease", "sustained-release", "verapamil", "or", "to", "atenolol", "as", "initial", "C0991617#ent", "<e1>", ",", "followed", "by", "trandolapril", "or", "C0020261#ent", "<e2>", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [24, 25]}}
{"token": ["During", "this", "study", ",", "a", "marked", "effect", "of", "the", "ionic", "strength", "the", "activities", "(", "hydroxylations", "of", "tienilic", "acid", "C0040374#ent", "<e1>", ")", "of", "these", "C0051169#ent", "<e2>", "expressed", "in", "the", "yeast", "strain", "was", "observed", "."], "h": {"id": "C0040374", "name": "C0040374#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [23, 24]}}
{"token": ["Purification", "and", "immunoinhibition", "studies", "have", "suggested", "that", "the", "hydroxylations", "of", "(S)-mephenytoin", "and", "C0040374#ent", "<e1>", "are", "catalyzed", "by", "rather", "similar", "forms", "of", "human", "C0051169#ent", "<e2>", "P-450", ")", "."], "h": {"id": "C0040374", "name": "C0040374#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [22, 23]}}
{"token": ["Based", "on", "these", "results", ",", "we", "propose", "that", "C1517683#ent", "<e1>", "induced", "growth", "arrest", "phosphorylation", "of", "C3829685#ent", "<e2>", "mediated", "by", "persistent", "ERK", "and", "p90RSK", "activation", "."], "h": {"id": "C1517683", "name": "C1517683#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3829685", "name": "C3829685#ent", "pos": [15, 16]}}
{"token": ["Its", "wide", "C0031381#ent", "<e1>", "substrate", "spectrum", "Sfp", "a", "biotechnologically", "valuable", "C0014442#ent", "<e2>", "for", "use", "in", "combinatorial", "non-ribosomal", "peptide", "synthesis", "."], "h": {"id": "C0031381", "name": "C0031381#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["These", "C0086376#ent", "<e1>", ",", "fusion", "and", "C2985502#ent", "<e2>", "(", "HN", ")", ",", "are", "involved", "in", "the", "immune", "response", "NDV", "infection", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2985502", "name": "C2985502#ent", "pos": [6, 7]}}
{"token": ["The", "majority", "of", "the", "DRG", "neurons", "were", "immunoreactive", "for", "C1415112#ent", "<e1>", "and", "all", "DRG", "neurons", "that", "contained", "C1704715#ent", "<e2>", "also", "contained", "C1415112#ent", "<e1>", "."], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415112", "name": "C1415112#ent", "pos": [9, 10]}}
{"token": ["Pharmacologic", "infusion", "of", "C0483249#ent", "<e1>", "APC", ")", "improves", "survival", "in", "severe", "C0243026#ent", "<e2>", ",", "and", "platelet", "factor", "4", "PF4", ")", "accelerates", "APC", "generation", "in", "a", "primate", "thrombin-infusion", "model", "."], "h": {"id": "C0483249", "name": "C0483249#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [11, 12]}}
{"token": ["Much", "interest", "focused", "on", "C0483249#ent", "<e1>", "APC", ")", "and", "other", "ways", "forward", "in", "C0243026#ent", "<e2>", "treatment", ",", "pain", "management", "novel", "markers", "of", "neurotrauma", "and", "antioxidants", "in", "bypass", "surgery"], "h": {"id": "C0483249", "name": "C0483249#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", "endogenous", "androgens", "may", "exert", "positive", "influences", "on", "C1826421#ent", "<e1>", ",", "and", "that", "C1366439#ent", "<e2>", "may", "have", "negative", "effects", "on", "C1826421#ent", "<e1>", "."], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1826421", "name": "C1826421#ent", "pos": [11, 12]}}
{"token": ["When", "FTI", "was", "entered", "into", "the", "regression", "model", "of", "C1366439#ent", "<e1>", ",", "it", "was", "not", "an", "independent", "predictor", "of", "C1826421#ent", "<e2>", "."], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826421", "name": "C1826421#ent", "pos": [19, 20]}}
{"token": ["2-D", "gel", "electrophoresis", "C0059256#ent", "<e1>", "from", "cells", "identified", "5", "-", "8", "C0015230#ent", "<e2>", "."], "h": {"id": "C0059256", "name": "C0059256#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [11, 12]}}
{"token": ["Expression", "of", "C.", "acutatum", "wild-type", "nitrate", "reductase", "(", "C1417732#ent", "<e1>", ")", "and", "C1415119#ent", "<e2>", "gln1", ")", "was", "induced", "by", "nitrate", "but", "only", "C1417732#ent", "<e1>", "expression", "was", "repressed", "in", "a", "rich", "medium"], "h": {"id": "C1415119", "name": "C1415119#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417732", "name": "C1417732#ent", "pos": [8, 9]}}
{"token": ["This", "rare", "neurological", "manifestation", "C3495801#ent", "<e1>", "was", "treated", "successfully", "with", "oral", "C0010583#ent", "<e2>", "and", "the", "patient", "has", "continued", "remission", "for", "3", "years", "taking", "oral", "methotrexate", "."], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [11, 12]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "evaluate", "the", "effect", "of", "treatment", "with", "anti-thymocyte", "globulin", "patients", "with", "C3495801#ent", "<e1>", "untreatable", "with", "C0010583#ent", "<e2>", "and", "steroids", "."], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [21, 22]}}
{"token": ["BACKGROUND", "AND", "QUESTION", ":", "The", "prognosis", "of", "patients", "with", "Wegener's", "granulomatosis", "C3495801#ent", "<e1>", ")", "refractory", "to", "standard", "treatment", "the", "induction", "of", "remission", "C0010583#ent", "<e2>", "and", "steroids", ")", "has", "been", "poor", "so", "far", "."], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [22, 23]}}
{"token": ["A", "similar", "molecular", "pathogenesis", "be", "logically", "hypothesized", "for", "various", "other", "processes", "involving", "connective", "tissue", "in", "scleroderma", ",", "pretibial", "myxoedema", "cheloids", ",", "C1337007#ent", "<e1>", "aging", "and", "C3536709#ent", "<e2>", "induced", "atrophy", "."], "h": {"id": "C1337007", "name": "C1337007#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [25, 26]}}
{"token": ["Anthocyanins", ",", "natural", "food", "antioxidants", "can", "be", "identified", "in", "human", "blood", "plasma", "a", "restricted", "access", "phase", "for", "removal", "of", "the", "C0086376#ent", "<e1>", "and", "enrichment", "of", "the", "C0175820#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0175820", "name": "C0175820#ent", "pos": [26, 27]}}
{"token": ["We", "investigated", "the", "effect", "of", "C0969232#ent", "<e1>", "on", "the", "UVB-induced", "accumulation", "and", "stabilization", "of", "the", "C1705526#ent", "<e2>"], "h": {"id": "C0969232", "name": "C0969232#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "C0969232#ent", "<e1>", "severely", "reduced", "N-terminal", "phosphorylation", "C1705526#ent", "<e2>", "."], "h": {"id": "C0969232", "name": "C0969232#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [8, 9]}}
{"token": ["Tissue", "inhibitors", "metalloproteinases", "(", "TIMPs", ")", "are", "the", "endogenous", "inhibitors", "of", "the", "matrix", "metalloproteinases", "the", "ADAMs", "(", "a", "disintegrin", "and", "C1334706#ent", "<e1>", ")", "and", "the", "C1257533#ent", "<e2>", "(", "ADAM", "with", "thrombospondin", "repeats", "proteinases", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1257533", "name": "C1257533#ent", "pos": [25, 26]}}
{"token": ["Platelet", "activation", "HOCl-LDL", "and", "ADP", "(", "1", "microM", ")", "caused", "P-selectin", "(", "C1335809#ent", "<e1>", ")", "exposure", ",", "without", "serotonin", "or", "adenosine", "triphosphate", "C1705556#ent", "<e2>", ")", "secretion", "."], "h": {"id": "C1335809", "name": "C1335809#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [22, 23]}}
{"token": ["This", "paper", "introduces", "a", "proof-of-concept", "trial", "in", "progress", ",", "supposedly", "providing", "new", "important", "information", "on", "C2963157#ent", "<e1>", "in", "patients", "with", "C1704436#ent", "<e2>", "PAD", ")", "."], "h": {"id": "C2963157", "name": "C2963157#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [20, 21]}}
{"token": ["C0268579#ent", "<e1>", "NKH", ")", "is", "an", "inborn", "error", "the", "glycine", "cleavage", "system", "in", "C0036572#ent", "<e2>", "and", "mental", "retardation"], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["C0268579#ent", "<e1>", "an", "inherited", "neurometabolic", "disorder", "by", "progressive", "neurological", "deterioration", "psychomotor", "delay/mental", "retardation", "C0036572#ent", "<e2>", "and", "coma", ",", "and", "whose", "pathophysiology", "is", "poorly", "unknown", "."], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["In", "the", "PTEN-positive", "C1335222#ent", "<e1>", ",", "PNT1a", "and", "P4E6", ",", "PI3K", "inhibition", "by", "C0251991#ent", "<e2>", "caused", "rapid", "dephosphorylation", "of", "PKB", "at", "ser473", "(", "T(1/2)<2", "min", ")", ",", "leading", "to", "its", "inactivation", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0251991", "name": "C0251991#ent", "pos": [13, 14]}}
{"token": ["C1418938#ent", "<e1>", "treatment", "of", "HC11", "cells", "increased", "phosphorylation", "of", "C1705050#ent", "<e2>", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705050", "name": "C1705050#ent", "pos": [9, 10]}}
{"token": ["A", "well", "studied", "paradigm", "for", "a", "synergistic", "co-operation", "is", "the", "activation", "of", "beta-casein", "gene", "transcription", "C1418938#ent", "<e1>", "and", "glucocorticoids", "mediated", "by", "the", "signal", "transducer", "activator", "of", "transcription", "C1705050#ent", "<e2>", "and", "the", "glucocorticoid", "receptor", "GR", ")", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705050", "name": "C1705050#ent", "pos": [27, 28]}}
{"token": ["Jak2", "and", "Stat1", "phosphorylation", "were", "induced", "by", "C1418938#ent", "<e1>", "within", "10", "min", "and", "C1705050#ent", "<e2>", "within", "30", "min", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705050", "name": "C1705050#ent", "pos": [13, 14]}}
{"token": ["Alpha1-antitrypsin", "deficiency", "C0004135#ent", "<e1>", ")", "is", "a", "common", "hereditary", "disorder", "associated", "with", "high", "risk", "developing", "C0034067#ent", "<e2>", "early", "in", "life", "and", ",", "to", "a", "lesser", "extent", ",", "chronic", "liver", "disease", "cirrhosis", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034067", "name": "C0034067#ent", "pos": [15, 16]}}
{"token": ["High", "concentrations", "(", "10", "microM", ")", "of", "the", "most", "potent", "acetylenic", "(carboxylalkyl)benzyl", "ethers", "did", "not", "inhibit", "human", "C1412356#ent", "<e1>", "human", "neutrophil", "5-LO", ",", "rabbit", "reticulocyte", "C2348848#ent", "<e2>", ",", "or", "soybean", "C2348848#ent", "<e2>", "."], "h": {"id": "C1412356", "name": "C1412356#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2348848", "name": "C2348848#ent", "pos": [25, 26]}}
{"token": ["C1412356#ent", "<e1>", "IC50", "=", "3.0", "microM", ")", "is", "inhibited", ",", "but", "C2348848#ent", "<e2>", "is", "only", "weakly", "so", "(", "IC50", "=", "157", "microM", ")", "."], "h": {"id": "C1412356", "name": "C1412356#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2348848", "name": "C2348848#ent", "pos": [11, 12]}}
{"token": ["The", "higher", "dose", "of", "insulin", "prevented", "the", "C0011884#ent", "<e1>", "increase", "in", "glomerular", "C1826724#ent", "<e2>", "activity", ",", "although", "blood", "glucose", "levels", "not", "normalized", "."], "h": {"id": "C0011884", "name": "C0011884#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [12, 13]}}
{"token": ["C1416902#ent", "<e1>", "activity", "toward", "C0872351#ent", "<e2>", "containing", "2", "mol", "%", "TO", "was", "enhanced", "2.6-fold", "by", "the", "addition", "of", "5", "mol", "%", "CO", ";", "cholesteryl", "ester", "no", "effect", "H-TGL", "activity", "."], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [4, 5]}}
{"token": ["The", "effect", "of", "apolipoprotein", "C-II", "synthetic", "peptides", "the", "phospholipase", "A1", "of", "C1416902#ent", "<e1>", "examined", "in", "sphingomyelin", ":", "cholesterol", "(", "2:1", ")", "C0872351#ent", "<e2>", "containing", "5", "mol%", "di[14C]myristoylphosphatidylcholine", "."], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [21, 22]}}
{"token": ["C1416902#ent", "<e1>", "activity", "toward", "C0872351#ent", "<e2>", "containing", "2", "mol", "percent", "trioleoylglycerol", "was", "enhanced", "2.6-fold", "by", "the", "addition", "of", "5", "mol", "percent", "cholesteryl", "oleate", "cholesteryl", "ester", "no", "effect", "H-TGL", "activity", "."], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [4, 5]}}
{"token": ["The", "C0039082#ent", "<e1>", "of", "androgen", "insensitivity", ",", "a", "paradigm", "of", "a", "C2940786#ent", "<e2>", "manifests", "as", "failure", "of", "masculinization", "despite", "normal", "or", "high", "concentrations", "of", "serum", "testosterone"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C2940786", "name": "C2940786#ent", "pos": [11, 12]}}
{"token": ["Until", "recently", ",", "identifying", "the", "specificities", "of", "C0014442#ent", "<e1>", "that", "post-translationally", "modify", "core", "histones", "performed", "in", "vitro", "synthetic", "peptides", "purified", "C0021345#ent", "<e2>", "or", "short", "nucleosome", "arrays", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [20, 21]}}
{"token": ["Included", "are", "Whipple's", "disease", "abetalipoproteinemia", ",", "collagenous", "sprue", "primary", "intestinal", "lymphoma", "eosinophilic", "gastroenteritis", "giardiasis", ",", "coccidiosis", ",", "strongyloidiasis", ",", "C0024214#ent", "<e1>", "and", "the", "C0019693#ent", "<e2>"], "h": {"id": "C0024214", "name": "C0024214#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [23, 24]}}
{"token": ["Medullary", "tubule", "preparations", "(", "MCT", "and", "C3273340#ent", "<e1>", ")", "were", "mostly", "negative", "for", "C1414438#ent", "<e2>", "mRNA", ",", "and", "glomeruli", "were", "uniformly", "negative", "."], "h": {"id": "C3273340", "name": "C3273340#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [13, 14]}}
{"token": ["Additional", "experiments", "suggest", "that", "Gi2", "stimulates", "the", "MAPK", "pathway", "at", "least", "in", "part", ",", "by", "mechanisms", "that", "involve", "release", "of", "its", "C1415155#ent", "<e1>", "as", "well", "as", "activation", "of", "C0044602#ent", "<e2>"], "h": {"id": "C1415155", "name": "C1415155#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [28, 29]}}
{"token": ["Fifty-two", "patients", "with", "C0035457#ent", "<e1>", "admitted", "to", "a", "randomized", "clinical", "comparison", "budesonide", "(", "Rhinocort", ")", "and", "C0004906#ent", "<e2>", "Becotide", "Nasal", ")", "."], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0004906", "name": "C0004906#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "much", "more", "attention", "has", "been", "focused", "on", "the", "human", "formyl", "peptide", "receptor", "C1333574#ent", "<e1>", ")", "and", "its", "variant", "formyl", "peptide", "receptor-like", "1", "FPRL1", ")", "and", "C1414692#ent", "<e2>", "FPRL2", ")", "."], "h": {"id": "C1333574", "name": "C1333574#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414692", "name": "C1414692#ent", "pos": [27, 28]}}
{"token": ["C1826421#ent", "<e1>", "in", "HD", "patients", "was", "negatively", "related", "with", "PTH", ",", "C1427121#ent", "<e2>", "and", "rate", "of", "subperiosteal", "erosions", "."], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427121", "name": "C1427121#ent", "pos": [11, 12]}}
{"token": ["The", "RecQ4", "helicase", "as", "large", "as", "the", "Bloom", "(", "C0005859#ent", "<e1>", ")", "and", "Werner", "(", "WRN", ")", "C0084378#ent", "<e2>", ",", "and", "its", "gene", "expression", "profile", "organ-specific", ",", "resembling", "that", "of", "BLM", "helicase", "."], "h": {"id": "C0005859", "name": "C0005859#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0084378", "name": "C0084378#ent", "pos": [17, 18]}}
{"token": ["Comparison", "of", "these", "nucleotide", "sequences", "strong", "homology", "in", "the", "regions", "containing", "C1419242#ent", "<e1>", ",", "traI", "and", "an", "C0079941#ent", "<e2>", "named", "orfD", ")", "."], "h": {"id": "C1419242", "name": "C1419242#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [17, 18]}}
{"token": ["Anticholinergic", "drugs", "used", "consistently", "less", "frequently", "as", "concomitant", "medication", "to", "alleviate", "extrapyramidal", "symptoms", "the", "C0073047#ent", "<e1>", "group", ":", "the", "use", "of", "C0020592#ent", "<e2>", "was", "approximately", "the", "same", "in", "both", "groups", "."], "h": {"id": "C0073047", "name": "C0073047#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [21, 22]}}
{"token": ["During", "the", "examination", "period", ",", "the", "patients", "received", "analgesic", ",", "sedative", ",", "and", "C0358430#ent", "<e1>", "but", "no", "C0012798#ent", "<e2>", "."], "h": {"id": "C0358430", "name": "C0358430#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [17, 18]}}
{"token": ["Reductive", "and", "oxidative", "redox", "titrations", "demonstrate", "that", "the", "C1705457#ent", "<e1>", "of", "the", "C2239920#ent", "<e2>", "form", "is", "at", "about", "+", "150", "mV."], "h": {"id": "C1705457", "name": "C1705457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2239920", "name": "C2239920#ent", "pos": [12, 13]}}
{"token": ["In", "chick", "embryo", "cells", "infected", "with", "C0016627#ent", "<e1>", "an", "avian", "strain", "of", "C0021400#ent", "<e2>", "produces", "cytopathic", "effects", "lysosomal", "enzymes", "released", "from", "the", "particulate", "to", "the", "supernatant", "fraction", "of", "homogenates", "within", "6", "hours", "of", "infection", "."], "h": {"id": "C0016627", "name": "C0016627#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [12, 13]}}
{"token": ["To", "investigate", "the", "relationship", "between", "C1336626#ent", "<e1>", ",", "Angiostatin", "and", "C0534628#ent", "<e2>", "serum", "concentrations", "and", "progression", "of", "pancreatic", "adenocarcinoma"], "h": {"id": "C1336626", "name": "C1336626#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0534628", "name": "C0534628#ent", "pos": [10, 11]}}
{"token": ["C1706047#ent", "<e1>", "is", "required", "for", "survival", "of", "replicational", "stress", "by", "C0035064#ent", "<e2>", "that", "stall", "replication", "forks", "but", "how", "C1706047#ent", "<e1>", "performs", "these", "functions", "is", "largely", "unknown", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706047", "name": "C1706047#ent", "pos": [0, 1]}}
{"token": ["Practolol", "was", "ineffective", ",", "while", "C0354872#ent", "<e1>", "potentiated", "the", "effect", "of", "C0024778#ent", "<e2>", "and", "was", "inactive", "towards", "imipramine", "and", "desipramine", "."], "h": {"id": "C0354872", "name": "C0354872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024778", "name": "C0024778#ent", "pos": [11, 12]}}
{"token": ["But", "C0014894#ent", "<e1>", "and", "trypsin", "of", "macrophage", "membrane", "T-cells", "to", "release", "C1412384#ent", "<e2>", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412384", "name": "C1412384#ent", "pos": [11, 12]}}
{"token": ["The", "C1337113#ent", "<e1>", "SWI/SNF", ")", "complex", "subunits", "C1335841#ent", "<e2>", "and", "SNR1", "are", "highly", "conserved", "with", "direct", "counterparts", "in", "yeast", "(", "SWI2/SNF2", "and", "SNF5", ")", "and", "mammals", "(", "BRG1/hBRM", "and", "INI1/hSNF5", ")", "."], "h": {"id": "C1337113", "name": "C1337113#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335841", "name": "C1335841#ent", "pos": [7, 8]}}
{"token": ["Here", ",", "we", "show", "that", "mutations", "affecting", "C1337113#ent", "<e1>", "(", "BRM", ")", ",", "a", "C1335841#ent", "<e2>", "chromatin-remodeling", "ATPase", "cause", "ectopic", "expression", "of", "a", "subset", "of", "SSPs", "and", "other", "embryogenesis-related", "genes", "leaf", "tissue"], "h": {"id": "C1337113", "name": "C1337113#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335841", "name": "C1335841#ent", "pos": [14, 15]}}
{"token": ["The", "series", "included", "non-inflammatory", "diseases", "as", "C0014547#ent", "<e1>", ",", "amyotrophic", "lateral", "sclerosis", "and", "polyneuropathy", ";", "and", "C0033581#ent", "<e2>", "as", "multiple", "sclerosis", "neurolues", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [16, 17]}}
{"token": ["Histopathologically", "and", "ultrastructurally", ",", "any", "manifestations", "of", "C0003850#ent", "<e1>", "elsewhere", "in", "the", "C1706333#ent", "<e2>", "are", "suppressed", "in", "the", "intima", "beneath", "the", "MB", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706333", "name": "C1706333#ent", "pos": [12, 13]}}
{"token": ["Our", "data", "also", "demonstrated", "that", "the", "cauda", "epididymis", "C0269173#ent", "<e1>", "an", "apoD", "mRNA", "concentration", "100-fold", "higher", "than", "the", "C0023899#ent", "<e2>", ",", "suggesting", "that", "the", "apoD", "gene", "expression", "be", "associated", "with", "presence", "of", "steroids", "."], "h": {"id": "C0269173", "name": "C0269173#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}}
{"token": ["The", "levels", "of", "the", "1-kb", "mRNA", "increased", "in", "the", "C0269173#ent", "<e1>", "ovaries", "during", "gestation", "and", "were", "lower", "in", "fetal", "reproductive", "tissues", "C0023899#ent", "<e2>", "than", "in", "mature", "animals", "."], "h": {"id": "C0269173", "name": "C0269173#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [21, 22]}}
{"token": ["Intravesical", "bacillus", "C3830467#ent", "<e1>", "has", "been", "found", "to", "cause", "an", "C0162323#ent", "<e2>"], "h": {"id": "C3830467", "name": "C3830467#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162323", "name": "C0162323#ent", "pos": [10, 11]}}
{"token": ["C0012582#ent", "<e1>", "enhanced", "PGI2", "biosynthesis", "while", "vitamin", "E", "C0006507#ent", "<e2>", "no", "effect", "PGI2", "biosynthesis", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006507", "name": "C0006507#ent", "pos": [8, 9]}}
{"token": ["Globally", ",", "our", "results", "suggest", "that", "axotomy-induced", "death", "of", "ganglion", "cells", "the", "activation", "of", "CDK1", ",", "C0108855#ent", "<e1>", ",", "or", "C1332735#ent", "<e2>", "(", "most", "probably", "C1332735#ent", "<e2>", ")", "but", "not", "the", "full", "cell", "cycle", "machinery"], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332735", "name": "C1332735#ent", "pos": [20, 21]}}
{"token": ["As", "rat", "primary", "oligodendrocytes", "differentiate", "in", "culture", "there", "is", "a", "fall", "in", "C0108855#ent", "<e1>", "activity", "and", "a", "rise", "in", "C1332735#ent", "<e2>", "activity", "as", "well", "as", "an", "increase", "in", "the", "cdk", "inhibitor", "p27", "protein"], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332735", "name": "C1332735#ent", "pos": [19, 20]}}
{"token": ["The", "typical", "outcome", "of", "these", "patients", "is", "towards", "the", "development", "of", "chronic", "synovitis", "and", "later", "on", "to", "C0263725#ent", "<e1>", "if", "the", "state", "of", "C1739148#ent", "<e2>", "is", "not", "promptly", "and", "adequately", "controlled", "."], "h": {"id": "C0263725", "name": "C0263725#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1739148", "name": "C1739148#ent", "pos": [23, 24]}}
{"token": ["This", "was", "associated", "with", "progressive", "C1839163#ent", "<e1>", "and", "leucocytosis", "as", "the", "degree", "of", "C0242723#ent", "<e2>", "increased", "with", "time", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242723", "name": "C0242723#ent", "pos": [13, 14]}}
{"token": ["C1839163#ent", "<e1>", "closely", "corresponded", "to", "C0242723#ent", "<e2>", "and", "to", "von", "Willebrand", "factor", "levels", "but", "appeared", "not", "to", "be", "linked", "to", "a", "consumption", "of", "coagulation", "factors"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242723", "name": "C0242723#ent", "pos": [5, 6]}}
{"token": ["The", "C1420710#ent", "<e1>", "encoded", "by", "a", "transforming", "growth", "factor-beta1-", "C3811704#ent", "<e2>", "hic-5", ",", "and", "has", "striking", "similarity", "to", "paxillin", ",", "especially", "in", "their", "C-terminal", "LIM", "domains"], "h": {"id": "C1420710", "name": "C1420710#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811704", "name": "C3811704#ent", "pos": [9, 10]}}
{"token": ["We", "have", "expressed", "the", "alpha", "1", "A", "calcium", "channel", "subunit", ",", "and", "in", "combination", "with", "different", "C0599220#ent", "<e1>", "and", "investigated", "the", "effect", "of", "the", "external", "C3539699#ent", "<e2>", "+", "concentration", "on", "the", "voltage", "dependence", "activation", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [25, 26]}}
{"token": ["Interestingly", ",", "SP6", "RNA", "polymerase", "more", "sensitive", "to", "the", "DMSO", "stimulation", "than", "C0035681#ent", "<e1>", "suggesting", "that", "the", "C1335440#ent", "<e2>", "is", "an", "important", "target", "for", "DMSO", "stimulation", "of", "RNA", "synthesis"], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [17, 18]}}
{"token": ["Three", "cases", "of", "C0238339#ent", "<e1>", "in", "patients", "with", "C0267498#ent", "<e2>", "bacterial", "overgrowth", "reported", "."], "h": {"id": "C0238339", "name": "C0238339#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0267498", "name": "C0267498#ent", "pos": [8, 9]}}
{"token": ["We", "report", "that", "an", "L-selectin", "mutant", "generated", "by", "truncation", "of", "the", "COOH-terminal", "11", "residues", "of", "L-selectin", "tail", "which", "impairs", "association", "with", "the", "C1414120#ent", "<e1>", "alpha-actinin", ",", "could", "capture", "leukocytes", "to", "C1419941#ent", "<e2>", "physiological", "shear", "flow"], "h": {"id": "C1414120", "name": "C1414120#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1419941", "name": "C1419941#ent", "pos": [30, 31]}}
{"token": ["Whereas", "C0295113#ent", "<e1>", "and", "LY272015", "had", "no", "effects", "bath", "application", "C1517662#ent", "<e2>", "disturbed", "and", "blocked", "rhythmic", "activity", "."], "h": {"id": "C0295113", "name": "C0295113#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggest", "that", "C1538681#ent", "<e1>", "stimulation", "activates", "an", "C0002772#ent", "<e2>", "mechanism", "that", "is", "selectively", "active", "at", "a", "supraspinal", "level", "and", "diminishes", "the", "affective", "consequences", "otherwise", "noxious", "stimuli", "."], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002772", "name": "C0002772#ent", "pos": [9, 10]}}
{"token": ["HSP70", ",", "DnaJ-like", "protein", "C0292378#ent", "<e1>", "among", "the", "constitutively", "induced", "C0017337#ent", "<e2>", "."], "h": {"id": "C0292378", "name": "C0292378#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["The", "5'-flanking", "sequence", "the", "rat", "C1417039#ent", "<e1>", "no", "significant", "similarity", "with", "those", "of", "the", "C1417038#ent", "<e2>", "genes", "."], "h": {"id": "C1417039", "name": "C1417039#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417038", "name": "C1417038#ent", "pos": [14, 15]}}
{"token": ["C1417039#ent", "<e1>", "antisense", "treatment", "reduced", "the", "amount", "of", "C1417039#ent", "<e1>", "mRNA", "by", "99", "%", "but", "had", "no", "effect", "C1417038#ent", "<e1>", "mRNA", "."], "h": {"id": "C1417039", "name": "C1417039#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417038", "name": "C1417038#ent", "pos": [18, 19]}}
{"token": ["Finally", ",", "growth", "inhibitors", "as", "transforming", "growth", "factor", "TGF", ")", "beta", "blocked", "HGF-induced", "C1417039#ent", "<e1>", "up-regulation", "while", "increasing", "C1417038#ent", "<e2>", "mRNA", "levels", "in", "H35", "cells", "."], "h": {"id": "C1417039", "name": "C1417039#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417038", "name": "C1417038#ent", "pos": [18, 19]}}
{"token": ["Here", "we", "find", "that", "cholesterol", "specifically", "promotes", "the", "internalization", "of", "C1417777#ent", "<e1>", "and", "that", "this", "process", "requires", "C1334752#ent", "<e2>", "and", "the", "clathrin/AP2", "complex", "."], "h": {"id": "C1417777", "name": "C1417777#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334752", "name": "C1334752#ent", "pos": [17, 18]}}
{"token": ["The", "fluorescence", "polarization", "C0023899#ent", "<e1>", "plasma", "membranes", "was", "increased", "by", "C0175697#ent", "<e2>", ",", "but", "that", "of", "plasma", "membranes", "the", "renal", "cortex", "slightly", "decreased", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [10, 11]}}
{"token": ["The", "purified", "17.109", "CRI-positive", "material", "from", "the", "sera", "of", "C0003873#ent", "<e1>", "patients", ",", "Sjogren's", "syndrome", "patients", ",", "and", "normal", "subjects", "exclusively", "C1366332#ent", "<e2>", "and", "had", "demonstrated", "RF", "activity", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366332", "name": "C1366332#ent", "pos": [21, 22]}}
{"token": ["Mutations", "in", "C0268141#ent", "<e1>", "can", "lead", "to", "the", "disorders", "xeroderma", "pigmentosum", "XP", ")", "and", "C1333359#ent", "<e2>"], "h": {"id": "C0268141", "name": "C0268141#ent", "pos": [2, 3]}, "relation": "disease_has_associated_gene", "t": {"id": "C1333359", "name": "C1333359#ent", "pos": [14, 15]}}
{"token": ["A", "comparison", "of", "the", "genomic", "structures", "the", "thus", "far", "known", "C1258132#ent", "<e1>", "that", "of", "the", "insect", "C3810569#ent", "<e2>", "a", "conservation", "of", "the", "positions", "of", "most", "introns", "interrupting", "the", "exons", "coding", "the", "amino-terminal", "and", "catalytic", "domains"], "h": {"id": "C1258132", "name": "C1258132#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [16, 17]}}
{"token": ["In", "this", "report", ",", "we", "describe", "a", "four-generation", "family", "with", "C4281938#ent", "<e1>", "presenting", "predominantly", "with", "trichoepitheliomas", "(", "resembling", "C2985249#ent", "<e2>", "phenotype", ")", "."], "h": {"id": "C4281938", "name": "C4281938#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2985249", "name": "C2985249#ent", "pos": [18, 19]}}
{"token": ["The", "C1414504#ent", "<e1>", ",", "however", ",", "inhibited", "by", "the", "C0243459#ent", "<e2>", "staurosporine", "."], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243459", "name": "C0243459#ent", "pos": [9, 10]}}
{"token": ["C1414504#ent", "<e1>", "and", "phorbol", "myristate", "acetate", "to", "stimulate", "endothelin-1", "peptide", "activating", "protein", "kinase", "C", "because", "the", "C0243459#ent", "<e2>", "abolished", "the", "thrombin-", "and", "phorbol", "myristate", "acetate-induced", "rise", "in", "endothelin-1", "but", "had", "no", "effect", "basal", "production"], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243459", "name": "C0243459#ent", "pos": [16, 17]}}
{"token": ["The", "Trp64", "-", "->Arg", "C0002085#ent", "<e1>", "of", "the", "C1704463#ent", "<e2>", "recently", "proposed", "to", "be", "associated", "with", "earlier", "onset", "of", "non-insulin-dependent", "diabetes", "mellitus", "NIDDM", ")", ",", "features", "of", "insulin", "resistance", "a", "tendency", "to", "gain", "weight"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704463", "name": "C1704463#ent", "pos": [8, 9]}}
{"token": ["This", "C1415900#ent", "<e1>", "activity", "could", "have", "been", "produced", "C0669365#ent", "<e2>", "or", "may", "have", "been", "induced", "by", "substances", "(", "inducers", ")", "in", "the", "environment", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}}
{"token": ["C0032285#ent", "<e1>", "improved", "with", "vancomycin", "and", "C0016277#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [6, 7]}}
{"token": ["Thrombin-stimulated", "decreases", "in", "PIP2", "and", "PIP", ",", "found", "in", "the", "presence", "of", "C1620102#ent", "<e1>", ",", "could", "be", "explained", "by", "the", "action", "of", "C0031669#ent", "<e2>", "the", "absence", "of", "resynthesis", "."], "h": {"id": "C1620102", "name": "C1620102#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [22, 23]}}
{"token": ["Our", "results", "suggest", "that", ",", "in", "addition", "to", "the", "C1423498#ent", "<e1>", ",", "furin-/caveolin-1-containing", "endosomes", "could", "represent", "a", "compartment", "where", "C0287990#ent", "<e2>", "processes", "its", "substrates", "at", "the", "basolateral", "domain", "of", "the", "hepatocyte", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0287990", "name": "C0287990#ent", "pos": [19, 20]}}
{"token": ["While", "C1417108#ent", "<e1>", "is", "an", "effective", "tocolytic", ",", "reductions", "in", "C1565860#ent", "<e2>", "only", "with", "maintained", "C1417108#ent", "<e1>", "exposure", "."], "h": {"id": "C1417108", "name": "C1417108#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "the", "epithelium", "in", "five", "of", "six", "cases", "of", "C1449563#ent", "<e1>", "stained", "with", "C1332745#ent", "<e2>", "MoAb", "and", "only", "one", "of", "six", "stained", "for", "S-100", "protein"], "h": {"id": "C1449563", "name": "C1449563#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332745", "name": "C1332745#ent", "pos": [15, 16]}}
{"token": ["Primary", "osteoma", "cutis", "also", "associated", "with", "C3494506#ent", "<e1>", "AHO", ")", ",", "which", "can", "include", "C0033806#ent", "<e2>", "also", "known", "as", "pseudohypoparathyroidism", "type", "Ia", "or", "normocalcaemic-type", "pseudohypoparathyroidism", "also", "known", "as", "pseudopseudohypoparathyroidism", ")", "."], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0033806", "name": "C0033806#ent", "pos": [14, 15]}}
{"token": ["These", "data", "imply", "that", "anti-Ro", "antibodies", "also", "bind", "the", "64-kD", "protein", "mediate", "C0023530#ent", "<e1>", "in", "patients", "with", "C0024141#ent", "<e2>", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [17, 18]}}
{"token": ["IgG", "therapy", "used", "to", "treat", "C0023530#ent", "<e1>", "in", "2", "male", "neonates", "of", "mothers", "with", "C0024141#ent", "<e2>", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [14, 15]}}
{"token": ["Our", "study", "was", "aimed", "at", "investigating", "the", "role", "of", "C1424337#ent", "<e1>", "as", "a", "C0079427#ent", "<e2>"], "h": {"id": "C1424337", "name": "C1424337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [13, 14]}}
{"token": ["C1424337#ent", "<e1>", "has", "also", "been", "found", "to", "be", "a", "candidate", "C0079427#ent", "<e2>", "might", "provide", "a", "new", "option", "for", "cancer", "gene", "therapy"], "h": {"id": "C1424337", "name": "C1424337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [10, 11]}}
{"token": ["The", "effectiveness", "of", "therapy", "involving", "intravenous", "administration", "methimazole", "applied", "in", "patients", "with", "C3831153#ent", "<e1>", "resistant", "to", "oral", "C0010858#ent", "<e2>", "been", "investigated", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [17, 18]}}
{"token": ["Relevant", "immunomodulatory", "mechanisms", "act", "both", "on", "T-", "and", "B-cell", "function", "and", "C0026259#ent", "<e1>", "has", "selective", "immune", "effects", "MS", "by", "decreasing", "levels", "of", "C0812246#ent", "<e2>", ",", "IL-2", ",", "IL-2R-beta1", ",", "IL-10", "and", "IFN-gamma", "."], "h": {"id": "C0026259", "name": "C0026259#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [22, 23]}}
{"token": ["C0020261#ent", "<e1>", "(", "HCTZ", ")", "is", "used", "to", "manage", "hypertension", "and", "C0018801#ent", "<e2>", "however", ",", "its", "side", "effects", "mild", "hypokalemia", "metabolic", "abnormalities", "and", "volume", "depletion", "which", "might", "have", "deleterious", "effects", "renal", "and", "endothelial", "function"], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}}
{"token": ["In", "equivalent", "potassium-retaining", "doses", ",", "amiloride", "is", "associated", "with", "lower", "plasma", "sodium", "levels", "than", "triamterene", ",", "when", "given", "in", "combination", "with", "C0020261#ent", "<e1>", "in", "elderly", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [27, 28]}}
{"token": ["Seven", "adult", "patients", "with", "nongonococcal", "polyarticular", "C1692886#ent", "<e1>", "presented", "with", "a", "literature", "review", "the", "clinical", "features", "of", "polyarticular", "C0004623#ent", "<e2>"], "h": {"id": "C1692886", "name": "C1692886#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [18, 19]}}
{"token": ["We", "studied", "a", "mouse", "model", "the", "haploinsufficiency", "form", "of", "C0035934#ent", "<e1>", "RTS", ")", ",", "an", "C0019247#ent", "<e2>", "by", "mutations", "in", "the", "gene", "encoding", "the", "CREB", "binding", "protein", "CBP", ")", "and", "characterized", "by", "mental", "retardation", "skeletal", "abnormalities"], "h": {"id": "C0035934", "name": "C0035934#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [15, 16]}}
{"token": ["Reiter's", "disease", "C1422315#ent", "<e1>", ")", "is", "a", "C0085435#ent", "<e2>", "which", "arthritis", ",", "conjunctivitis", ",", "dermatitis", ",", "and", "urethritis", "are", "the", "main", "features", "."], "h": {"id": "C1422315", "name": "C1422315#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085435", "name": "C0085435#ent", "pos": [7, 8]}}
{"token": ["C0003152#ent", "<e1>", "developed", "due", "to", "C0041188#ent", "<e2>", "in", "a", "33-year-old", "male", "patient", "with", "rheumatoid", "arthritis", "receiving", "steroid", "therapy", "the", "follow-up", "period", "."], "h": {"id": "C0003152", "name": "C0003152#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041188", "name": "C0041188#ent", "pos": [5, 6]}}
{"token": ["The", "mutant", "and", "wild-type", "(", "ada+", ")", "cells", "contained", "similar", "C0907533#ent", "<e1>", "levels", "of", "C1334505#ent", "<e2>", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334505", "name": "C1334505#ent", "pos": [14, 15]}}
{"token": ["nRap", "C1415311#ent", "<e1>", "showed", "C1415311#ent", "<e1>", "activity", "for", "C1426113#ent", "<e1>", "but", "did", "not", "bind", "cAMP", "."], "h": {"id": "C1415311", "name": "C1415311#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1426113", "name": "C1426113#ent", "pos": [8, 9]}}
{"token": ["AR", "directly", "interacts", "with", "both", "Ku70", "and", "C1710692#ent", "<e1>", "in", "vivo", "in", "vitro", "as", "shown", "by", "co-immunoprecipitation", ",", "C0537086#ent", "<e2>", "and", "Sf9", "cell/baculovirus", "expression", "."], "h": {"id": "C1710692", "name": "C1710692#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "show", "that", "phosphorylated", "p38", "and", "C1452441#ent", "<e1>", "MK2", ")", "are", "colocalized", "with", "C1335227#ent", "<e2>", "to", "the", "spindle", "poles", "prophase", "and", "metaphase", "."], "h": {"id": "C1452441", "name": "C1452441#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [15, 16]}}
{"token": ["C0020514#ent", "<e1>", "induced", "by", "long-term", "C0013015#ent", "<e2>", "treatment", "did", "not", "change", "binding", "sites", "Bmax", ")", "and", "dissociation", "constant", "(", "Kd", ")", "of", "[3H]-spiroperidol", "binding", "when", "compared", "to", "controls", "."], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013015", "name": "C0013015#ent", "pos": [5, 6]}}
{"token": ["These", "30", "patients", "were", "in", "C0004057#ent", "<e1>", "II", "physical", "status", "cardiovascular", ",", "kidney", "or", "C0023895#ent", "<e2>"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [14, 15]}}
{"token": ["There", "were", "no", "differences", "in", "C0004057#ent", "<e1>", "sensitivity", "by", "race", ",", "diabetes", ",", "platelet", "count", "renal", "disease", "or", "C0023895#ent", "<e2>"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [18, 19]}}
{"token": ["To", "analyse", "the", "regulation", "of", "C1333577#ent", "<e1>", "in", "vitro", "we", "have", "purified", "Fyn", "and", "Csk", ",", "a", "C0031727#ent", "<e2>", "capable", "of", "regulating", "Fyn", "activity", "by", "phosphorylation", ",", "from", "baculovirus-infected", "insect", "cells", "."], "h": {"id": "C1333577", "name": "C1333577#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["Although", "the", "initial", "step", "is", "ascribed", "to", "C1333577#ent", "<e1>", "the", "role", "of", "individual", "C0031727#ent", "<e2>", "in", "phagocytosis", "signaling", "is", "still", "to", "be", "determined", "."], "h": {"id": "C1333577", "name": "C1333577#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["After", "repeated", "administrations", "of", "MOR", "and", "C0022625#ent", "<e1>", ",", "FI", "responses", "to", "the", "test", "dose", "these", "C0243192#ent", "<e2>", "injected", "in", "LH", "were", "modulated", "in", "opposite", "directions", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "125I-labeled", "CaM-binding", "peptide", "from", "C3889380#ent", "<e1>", "was", "efficiently", "crosslinked", "to", "the", "C3889380#ent", "<e1>", "suggesting", "that", "the", "inhibitory", "domain", "physically", "interacts", "with", "part(s", ")", "of", "the", "molecule", "."], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3889380", "name": "C3889380#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "we", "analyzed", "the", "C1563761#ent", "<e1>", "gross", "abnormalities", "the", "A3243", "G", "point", "mutation", "in", "the", "C0023414#ent", "<e2>", "because", "Wolfram", "syndrome", "phenotypic", "similarities", "with", "mitochondrial", "disease"], "h": {"id": "C1563761", "name": "C1563761#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023414", "name": "C0023414#ent", "pos": [16, 17]}}
{"token": ["The", "C0376259#ent", "<e1>", "previously", "been", "shown", "to", "prevent", "C1418544#ent", "<e2>", "aggregation", "and", "maintain", "the", "protein", "in", "an", "active", "conformation", "its", "mechanism", "of", "action", ",", "however", ",", "is", "unknown", "."], "h": {"id": "C0376259", "name": "C0376259#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418544", "name": "C1418544#ent", "pos": [8, 9]}}
{"token": ["Human", "susceptibility", "to", "infectious", "and", "inflammatory", "diseases", "including", "rheumatoid", "arthritis", "C0010346#ent", "<e1>", "and", "tuberculosis", ",", "shows", "C0002085#ent", "<e2>", "association", "with", "a", "highly", "polymorphic", "regulatory", "Z-DNA-forming", "microsatellite", "of", "(GT/AC)n", "dinucleotides", "within", "the", "proximal", "SLC11A1", "promoter", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [16, 17]}}
{"token": ["We", "have", "studied", "whether", "C0010346#ent", "<e1>", "CD", ")", "or", "ulcerative", "colitis", "UC", ")", "is", "associated", "with", "C0002085#ent", "<e2>", "combinations", "of", "IL1B/IL1RA", "gene", "polymorphisms", "in", "a", "different", "European", "population", "the", "ones", "studied", "so", "far", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [16, 17]}}
{"token": ["Previous", "studies", "have", "shown", "that", "age", "at", "menopause", "is", "an", "important", "indicator", "of", "C0720099#ent", "<e1>", "of", "endogenous", "C2936882#ent", "<e2>", "exposure", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [17, 18]}}
{"token": ["C0055687#ent", "<e1>", "is", "shown", "to", "inhibit", "C0249866#ent", "<e2>", "activation", "."], "h": {"id": "C0055687", "name": "C0055687#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0249866", "name": "C0249866#ent", "pos": [6, 7]}}
{"token": ["In", "a", "single-blind", ",", "placebo-controlled", "study", "C0116569#ent", "<e1>", "was", "administered", "intravenously", "to", "12", "patients", "with", "C0694539#ent", "<e2>"], "h": {"id": "C0116569", "name": "C0116569#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0694539", "name": "C0694539#ent", "pos": [15, 16]}}
{"token": ["administered", "C3495495#ent", "<e1>", ",", "and", "determined", "the", "disposition", "of", "C0246415#ent", "<e2>", "with", "and", "without", "the", "P-gp", "inhibitor", "."], "h": {"id": "C3495495", "name": "C3495495#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0246415", "name": "C0246415#ent", "pos": [9, 10]}}
{"token": ["Using", "a", "sensitive", "C0027203#ent", "<e1>", "linked", "immunosorbent", "assay", "we", "measured", "the", "serum", "C1414438#ent", "<e2>", "concentration", "in", "92", "HCC", "patients", "and", "30", "liver", "cirrhosis", "LC", ")", "patients", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [12, 13]}}
{"token": ["In", "order", "to", "map", "the", "C0012634#ent", "<e1>", "linkage", "analysis", "DNA", "polymorphisms", "used", "in", "C0011522#ent", "<e2>", "from", "23", "affected", "and", "8", "normal", "individuals", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [13, 14]}}
{"token": ["The", "sera", "of", "patients", "with", "autoimmune", "(", "AI", ")", "C0012634#ent", "<e1>", "contain", "antibodies", "with", "C0011522#ent", "<e2>", "and", "RNase", "activities"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [14, 15]}}
{"token": ["C0072523#ent", "<e1>", "effects", "were", "investigated", "in", "IEC18", ",", "HCT116", ",", "and", "AGS", "gastrointestinal", "cells", "treated", "with", "recombinant", "human", "C0072523#ent", "<e1>", ",", "and", "in", "stably", "transfected", "HCT116", "cells", "C0907533#ent", "<e1>", "or", "doxycycline-induced", "human", "C0072523#ent", "<e1>", "."], "h": {"id": "C0072523", "name": "C0072523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [27, 28]}}
{"token": ["We", "have", "previously", "described", "the", "effectiveness", "of", "a", "CRC", "assay", "composed", "of", "22", "known", "variants", "in", "C1537502#ent", "<e1>", ",", "APC", ",", "TP53", ",", "and", "C1879767#ent", "<e2>", "(", "V1", ")", "."], "h": {"id": "C1537502", "name": "C1537502#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1879767", "name": "C1879767#ent", "pos": [24, 25]}}
{"token": ["Immediately", "after", "the", "stress", "only", "C1415764#ent", "<e1>", "was", "found", "in", "association", "with", "C1334899#ent", "<e2>"], "h": {"id": "C1415764", "name": "C1415764#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [12, 13]}}
{"token": ["C57B1/6", "mice", "were", "given", "CY", "100", "or", "200", "mg/kg", "on", "day", "0", "followed", "48", "h", "later", "by", "C1705750#ent", "<e1>", "125", "micrograms/kg", "twice", "a", "day", "and/or", "C0879590#ent", "<e2>", "60000", "i.u", "."], "h": {"id": "C1705750", "name": "C1705750#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [25, 26]}}
{"token": ["C0917964#ent", "<e1>", "did", "not", "inhibit", "the", "activation", "of", "triacylglycerol", "lipase", "C1956039#ent", "<e2>", "the", "subsequent", "hydrolysis", "of", "triacylglycerol", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1956039", "name": "C1956039#ent", "pos": [10, 11]}}
{"token": ["Heart", "failure", "to", "C0041234#ent", "<e1>", "respond", "to", "digoxin", ",", "diuretics", "and", "C0042402#ent", "<e2>"], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [11, 12]}}
{"token": ["CCR5-/-", "mice", "exhibited", "significantly", "less", "peribronchial", "T-cell", "and", "C1306759#ent", "<e1>", "accumulation", "and", "airway-remodeling", "features", "such", "as", "C0027773#ent", "<e2>", "peribronchial", "fibrosis", "compared", "with", "CCR5+/+", "mice", "at", "these", "times", "after", "conidia", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027773", "name": "C0027773#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "C0146011#ent", "<e1>", "was", "reversed", "by", "C0304513#ent", "<e2>", "yohimbine", "and", "idazoxan", ",", "but", "not", "by", "an", "alpha", "1-antagonist", ",", "prazosin", "."], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0304513", "name": "C0304513#ent", "pos": [8, 9]}}
{"token": ["In", "general", ",", "C0812246#ent", "<e1>", "and", "FLU", "displayed", "a", "similar", "interaction", "with", "RS", "and", "C3539667#ent", "<e2>", "active", "sites", "PIR", "'s", "was", "different", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539667", "name": "C3539667#ent", "pos": [14, 15]}}
{"token": ["C3540800#ent", "<e1>", "treatment", "activated", "C0017932#ent", "<e2>", "inactivated", "glycogen", "phosphorylase", "a", "manner", "similar", "to", "that", "observed", "in", "fed-healthy", "rats", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [4, 5]}}
{"token": ["These", "findings", "demonstrate", "that", "although", "C3540800#ent", "<e1>", "appears", "to", "mimic", "the", "effects", "of", "insulin", "on", "C0017932#ent", "<e2>", "activity", ",", "its", "mechanism", "of", "action", "must", "be", "different", "from", "that", "of", "the", "hormone", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [15, 16]}}
{"token": ["Praziquantel", ",", "used", "to", "treat", "C0036323#ent", "<e1>", "is", "also", "effective", "in", "other", "C0040820#ent", "<e2>", "adult", "cestode", "infections"], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040820", "name": "C0040820#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "establish", "C1413850#ent", "<e1>", "as", "a", "key", "negative", "regulator", "of", "IKKepsilon/TBK1", "and", "suggest", "a", "role", "for", "C1413850#ent", "<e1>", "in", "the", "control", "of", "C1310468#ent", "<e1>", "ubiquitination", "."], "h": {"id": "C1413850", "name": "C1413850#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1310468", "name": "C1310468#ent", "pos": [23, 24]}}
{"token": ["Significant", "associations", "were", "found", "between", "thrombocytopenia", "and", "cardiac", "valves", "thickening", "dysfunction", ",", "C0014544#ent", "<e1>", ",", "chorea", ",", "arthritis", ",", "C0263401#ent", "<e2>", "skin", "ulcerations"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0263401", "name": "C0263401#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "the", "beneficial", "effects", "of", "statins", "on", "the", "airway", "hyperresponsiveness", "C0004096#ent", "<e1>", "we", "investigated", "the", "effects", "of", "systemic", "treatment", "lovastatin", "on", "the", "augmented", "BSM", "contraction", "and", "activation", "of", "C0812234#ent", "<e2>", "in", "rats", "with", "C0004096#ent", "<e1>"], "h": {"id": "C0812234", "name": "C0812234#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}}
{"token": ["Application", "of", "GC/MS/AMS", "to", "a", "current", "topic", "of", "interest", "was", "demonstrated", "in", "a", "model", "metabolomic", "study", "which", "cultured", "primary", "C0669372#ent", "<e1>", "were", "given", "[(14)C]glucose", "and", "C3541407#ent", "<e2>", "excreted", "into", "the", "culture", "medium", "analyzed", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3541407", "name": "C3541407#ent", "pos": [25, 26]}}
{"token": ["One", "mM", "C0027396#ent", "<e1>", "was", "incubated", "for", "6h", "with", "C0304925#ent", "<e2>", "(", "0.45", "mM", ")", "at", "37", "degrees", "C", "in", "a", "0.1", "M", "phosphate", "buffer", "pH", "7.4", ")", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0304925", "name": "C0304925#ent", "pos": [9, 10]}}
{"token": ["With", "the", "demonstration", "of", "identity", "between", "C3273109#ent", "<e1>", "and", "the", "low", "affinity", "IgE", "Fc", "receptor", "C1414549#ent", "<e2>", ",", "two", "previously", "separate", "avenues", "of", "immunological", "research", "converged", "into", "one", "."], "h": {"id": "C3273109", "name": "C3273109#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414549", "name": "C1414549#ent", "pos": [15, 16]}}
{"token": ["The", "low-affinity", "receptor", "for", "IgE", "C3273109#ent", "<e1>", ")", "as", "well", "as", "the", "soluble", "C1414549#ent", "<e2>", "IgE-BF", ",", "sCD23", ")", "are", "important", "factors", "in", "IgE", "antibody", "regulation", "."], "h": {"id": "C3273109", "name": "C3273109#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414549", "name": "C1414549#ent", "pos": [13, 14]}}
{"token": ["In", "addition", "to", "C0036421#ent", "<e1>", "there", "is", "no", "close", "correlation", "between", "C0011168#ent", "<e2>", "and", "Raynaud's", "phenomenon", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [11, 12]}}
{"token": ["These", "data", "indicate", "that", "ST6Gal", "I", "ST3Gal", "III", "and", "alpha1,2FT", "reduced", "the", "alpha-galactosyl", "epitope", "both", "C0072522#ent", "<e1>", "and", "glycosphingolipids", ",", "while", "C1417134#ent", "<e2>", "reduced", "them", "only", "in", "C0072522#ent", "<e1>", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417134", "name": "C1417134#ent", "pos": [21, 22]}}
{"token": ["To", "investigate", "further", "the", "role", "of", "T", "helper", "cells", "contributing", "to", "tissue", "damage", "C0042769#ent", "<e1>", "two", "additional", "ko", "strains", "(", "interleukin-4", "[", "IL-4", "]", "C1416746#ent", "<e2>", "and", "gamma", "interferon", "ko", "strains", "was", "examined", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416746", "name": "C1416746#ent", "pos": [24, 25]}}
{"token": ["C0022478#ent", "<e1>", "inhibited", "90", "%", "by", "C0031493#ent", "<e2>", "92", "%", "by", "D-Phe-Phe-Arg-chloromethylketone", ",", "91", "%", "by", "aprotinin", ",", "and", "only", "15", "%", "by", "soybean", "trypsin", "inhibitor"], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031493", "name": "C0031493#ent", "pos": [6, 7]}}
{"token": ["When", "the", "active", "site", "C0022478#ent", "<e1>", "was", "blocked", "by", "C0031493#ent", "<e2>", "D-Phe-D-Phe-L-Arg-CH2Cl", ",", "no", "complex", "formation", "was", "detected", "."], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031493", "name": "C0031493#ent", "pos": [9, 10]}}
{"token": ["C0037317#ent", "<e1>", "been", "reported", "in", "approximately", "80", "%", "of", "Tourette's", "syndrome", "C1413057#ent", "<e2>", ")", "patients", "."], "h": {"id": "C0037317", "name": "C0037317#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413057", "name": "C1413057#ent", "pos": [11, 12]}}
{"token": ["Major", "histocompatibility", "complex", "C0024518#ent", "<e1>", ")", "class", "I", "expression", "is", "reduced", "in", "several", "C0162628#ent", "<e2>", "but", "it", "is", "not", "known", "whether", "the", "same", "happens", "during", "infections", "caused", "by", "intracellular", "enterobacteria", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [13, 14]}}
{"token": ["The", "chemokine", "CCL20", "and", "C1533698#ent", "<e1>", "iNOS", ")", "were", "the", "most", "highly", "upregulated", "C0017337#ent", "<e2>", "by", "dynamic", "compression", "and", "this", "response", "was", "reduced", "by", "the", "Rho", "kinase", "inhibitors"], "h": {"id": "C1533698", "name": "C1533698#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["With", "C0020924#ent", "<e1>", "solution", "the", "C1823750#ent", "<e2>", "aggregated", "into", "regular", "elongated", "structures", "nano-\u00e9pis", ")", "on", "the", "substrate", "."], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823750", "name": "C1823750#ent", "pos": [5, 6]}}
{"token": ["The", "effect", "of", "the", "enzyme", "activity", "C0035100#ent", "<e1>", "was", "thus", "tested", "on", "C1415119#ent", "<e2>"], "h": {"id": "C0035100", "name": "C0035100#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415119", "name": "C1415119#ent", "pos": [12, 13]}}
{"token": ["Genetic", "experiments", "the", "action", "of", "discs", "overgrown", "upstream", "of", "the", "Fat", "pathway", "C0234238#ent", "<e1>", ",", "whereas", "C1367460#ent", "<e2>", "acts", "downstream", "of", "C0234238#ent", "<e1>", "."], "h": {"id": "C1367460", "name": "C1367460#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0234238", "name": "C0234238#ent", "pos": [12, 13]}}
{"token": ["The", "C1417245#ent", "<e1>", "several", "unusual", "properties", "compared", "to", "other", "C0027021#ent", "<e2>", ",", "e.g.", "a", "red-shifted", "absorption", "spectrum", "and", "a", "peroxidase", "activity", "towards", "chloride", "."], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [9, 10]}}
{"token": ["C1417245#ent", "<e1>", "is", "a", "member", "of", "a", "family", "of", "homologous", "mammalian", "C0027021#ent", "<e2>", "that", "includes", "thyroid", "peroxidase", "eosinophil", "peroxidase", "lactoperoxidase", "."], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [11, 12]}}
{"token": ["C1417245#ent", "<e1>", "will", "catalyse", "the", "peroxidation", "of", "the", "chloride", "ion", "C0027021#ent", "<e2>", "not", ";", "the", "product", "of", "this", "in", "neutral", "solution", "the", "hypochlorite", "ion", "which", "is", "also", "a", "reactive", "oxidizing", "agent"], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [10, 11]}}
{"token": ["TCR", "signaling", "commences", "with", "an", "early", "wave", "protein", "tyrosine", "kinase", "activation", "which", "is", "mediated", "by", "the", "Src", "kinases", "Lck", "Fyn", ",", "the", "70-kd", "C1527940#ent", "<e1>", "and", "members", "of", "the", "C0031727#ent", "<e2>"], "h": {"id": "C1527940", "name": "C1527940#ent", "pos": [23, 24]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [29, 30]}}
{"token": ["We", "describe", "a", "sensitive", ",", "reliable", "and", "reproducible", "method", ",", "based", "on", "three", "multiplex", "PCR", "assays", "for", "the", "rapid", "detection", "of", "seven", "common", "C0002312#ent", "<e1>", "deletions", "and", "one", "C0544482#ent", "<e2>"], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [23, 24]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0544482", "name": "C0544482#ent", "pos": [28, 29]}}
{"token": ["In", "C0002312#ent", "<e1>", "there", "are", "two", "C0544482#ent", "<e2>", "a", "23.0-kb", "Eco", "RI", "fragment", "and", "one", "on", "a", "19.0-kb", "fragment", "."], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [1, 2]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0544482", "name": "C0544482#ent", "pos": [6, 7]}}
{"token": ["C0497209#ent", "<e1>", "responsible", "for", "41", "%", "of", "consultations", "about", "eye", "problems", "C0009766#ent", "<e2>", "a", "further", "13", "%", ";", "70", "%", "of", "consultations", "resulted", "in", "a", "prescription", "."], "h": {"id": "C0497209", "name": "C0497209#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [11, 12]}}
{"token": ["Arginine-vasopressin", "(", "AVP", ")", "stimulates", "Na(+", ")", "transport", "and", "Na-K-ATPase", "activity", "via", "C0010531#ent", "<e1>", "PKA", "activation", "in", "the", "renal", "cortical", "collecting", "duct", "C0751951#ent", "<e2>", ")", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0751951", "name": "C0751951#ent", "pos": [22, 23]}}
{"token": ["In", "vivo", "of", "C0010531#ent", "<e1>", "and", "PKG", "antagonists", "transiently", "depressed", "behavioral", "hyperalgesia", "induced", "by", "C0751951#ent", "<e2>", "treatment", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751951", "name": "C0751951#ent", "pos": [14, 15]}}
{"token": ["We", "provide", "the", "first", "evidence", "that", "C1706326#ent", "<e1>", "itself", "has", "a", "carcinogenic", "property", "within", "the", "AML1/MTG8", "(", "C1539715#ent", "<e2>", ")", "fused", "gene", "."], "h": {"id": "C1706326", "name": "C1706326#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539715", "name": "C1539715#ent", "pos": [17, 18]}}
{"token": ["We", "also", "provide", "evidence", "that", "two", "wild", "types", "C1706326#ent", "<e1>", "transcripts", "containing", "the", "region", "of", "the", "C1539715#ent", "<e2>", "fused", "transcripts", "are", "expressed", "in", "hematopoietic", "cells", "different", "lineages", "."], "h": {"id": "C1706326", "name": "C1706326#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539715", "name": "C1539715#ent", "pos": [16, 17]}}
{"token": ["The", "t(8;21)", "translocation", "fuses", "the", "first", "177", "amino", "acids", "AML-1", "to", "C1706326#ent", "<e1>", "(", "also", "known", "as", "C1539715#ent", "<e2>", ")", ",", "generating", "a", "chimeric", "protein", "retains", "the", "DNA-binding", "domain", "AML-1", "."], "h": {"id": "C1706326", "name": "C1706326#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1539715", "name": "C1539715#ent", "pos": [17, 18]}}
{"token": ["This", "report", "describes", "a", "gene", ",", "C1366587#ent", "<e1>", ",", "that", "we", "isolated", "from", "the", "C2744579#ent", "<e2>", "human", "myeloid", "leukemia", "cell", "line", "phorbol", "ester-induced", "differentiation", "the", "monocyte/macrophage", "pathway"], "h": {"id": "C1366587", "name": "C1366587#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [14, 15]}}
{"token": ["Expression", "of", "the", "C1366587#ent", "<e1>", "mRNA", "was", "found", "to", "increase", "rapidly", "in", "C2744579#ent", "<e2>", "exposed", "to", "inducers", "of", "monocyte/macrophage", "differentiation", "phorbol", "esters", "lymphocyte", "conditioned", "medium", ",", "but", "not", "cells", "exposed", "to", "inducer", "of", "granulocyte", "differentiation", "retinoic", "acid", "."], "h": {"id": "C1366587", "name": "C1366587#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [12, 13]}}
{"token": ["The", "alpha'-chains", "of", "C5b", "and", "C6", "in", "the", "C5b-6", "complex", "C1706327#ent", "<e1>", "were", "susceptible", "to", "C0960371#ent", "<e2>", "."], "h": {"id": "C1706327", "name": "C1706327#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [15, 16]}}
{"token": ["In", "primary", "hyperparathyroidism", "C0020437#ent", "<e1>", "prevalence", "of", "acute", "and", "C0149521#ent", "<e2>", "10", "-", "-12", "times", "higher", "than", "in", "normal", "population"], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [9, 10]}}
{"token": ["It", "is", "known", "that", "C0020437#ent", "<e1>", "(", "hyperparathyroidism", ")", "is", "a", "cause", "of", "C0149521#ent", "<e2>", "noel-Jorand", "et", "al", ",", "1981b", ")", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [13, 14]}}
{"token": ["A", "transcriptional", "map", "this", "candidate", "gene", "region", "generated", "by", "analysis", "of", "exon", "amplification", ",", "has", "identified", "the", "genomic", "location", "four", "C0017337#ent", "<e1>", ",", "C1505758#ent", "<e2>", "glutathione", "peroxidase", "as", "well", "as", "two", "novel", ",", "previously", "uncharacterized", "C0017337#ent", "<e1>", "."], "h": {"id": "C1505758", "name": "C1505758#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["C0076115#ent", "<e1>", "is", "a", "potent", "drug", "in", "treating", "C0700345#ent", "<e2>"], "h": {"id": "C0076115", "name": "C0076115#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0700345", "name": "C0700345#ent", "pos": [8, 9]}}
{"token": ["The", "antimycotic", "action", "and", "tolerance", "to", "C0076115#ent", "<e1>", "in", "patients", "with", "C0700345#ent", "<e2>", "were", "evaluated", "in", "a", "blind", "study"], "h": {"id": "C0076115", "name": "C0076115#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0700345", "name": "C0700345#ent", "pos": [11, 12]}}
{"token": ["C0025303#ent", "<e1>", "present", "as", "sepsis", ",", "C0025289#ent", "<e2>", "or", "a", "combination", "of", "both", "."], "h": {"id": "C0025303", "name": "C0025303#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [6, 7]}}
{"token": ["The", "orientation", "of", "human", "C0916144#ent", "<e1>", "examined", "by", "enzymic", "iodination", "using", "C0022948#ent", "<e2>", "with", "the", "glucose-oxidase", "system", "for", "generating", "peroxide", ",", "followed", "by", "proteolytic", "digestion", "."], "h": {"id": "C0916144", "name": "C0916144#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022948", "name": "C0022948#ent", "pos": [11, 12]}}
{"token": ["C0002438#ent", "<e1>", "is", "a", "human", "disease", "by", "the", "protozoan", "C0021832#ent", "<e2>", "Entamoeba", "histolytica"], "h": {"id": "C0002438", "name": "C0002438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021832", "name": "C0021832#ent", "pos": [9, 10]}}
{"token": ["We", "provide", "evidence", "that", "the", "inhibition", "of", "C1333891#ent", "<e1>", "HDACs", ")", "blocks", "the", "C1414255#ent", "<e2>", "adult", "progenitor", "cells"], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414255", "name": "C1414255#ent", "pos": [13, 14]}}
{"token": ["The", "most", "suitable", "C0017302#ent", "<e1>", "thiopentone", ",", "dextromoramide", "or", "fentanyl", ",", "diazepam", "and", "C0030310#ent", "<e2>", "."], "h": {"id": "C0017302", "name": "C0017302#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030310", "name": "C0030310#ent", "pos": [13, 14]}}
{"token": ["Interaction", "with", "antibiotics", "and", "C0017302#ent", "<e1>", "not", "different", "from", "that", "of", "C0030310#ent", "<e2>", "."], "h": {"id": "C0017302", "name": "C0017302#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030310", "name": "C0030310#ent", "pos": [11, 12]}}
{"token": ["The", "labeled", "product", "was", "coincident", "with", "a", "band", "on", "C0056269#ent", "<e1>", "gels", "migrating", "slightly", "above", "an", "unlabeled", "C1414504#ent", "<e2>", "Mr", "approximately", "31,000", "."], "h": {"id": "C0056269", "name": "C0056269#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [17, 18]}}
{"token": ["C0109837#ent", "<e1>", "was", "six", "times", "more", "potent", "as", "a", "C0003286#ent", "<e2>", "when", "compared", "to", "trans-ACPD", "."], "h": {"id": "C0109837", "name": "C0109837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [9, 10]}}
{"token": ["C0030481#ent", "<e1>", "human", "T-lymphotropic", "virus", "type", "I", "myelopathy", "is", "a", "degenerative", "encephalomyelopathy", "with", "C0234133#ent", "<e2>", "affecting", "the", "lower", "extremities"], "h": {"id": "C0030481", "name": "C0030481#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [13, 14]}}
{"token": ["However", ",", "C1417205#ent", "<e1>", "detectable", "only", "when", "C1608879#ent", "<e2>", ",", "but", "not", "TIMP-2", ",", "was", "present", "."], "h": {"id": "C1417205", "name": "C1417205#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1608879", "name": "C1608879#ent", "pos": [7, 8]}}
{"token": ["The", "VAMS", "anxiety", "factor", "showed", "that", "C0123905#ent", "<e1>", "attenuated", "SPS-induced", "anxiety", "while", "CBD", "decreased", "anxiety", "after", "the", "C0085292#ent", "<e2>"], "h": {"id": "C0123905", "name": "C0123905#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085292", "name": "C0085292#ent", "pos": [17, 18]}}
{"token": ["Recent", "studies", "indicate", "that", "these", "agents", "also", "are", "useful", "in", "such", "diverse", "conditions", "as", "pulmonary", "and", "C0020538#ent", "<e1>", "hypertrophic", "cardiomyopathy", "arrhythmias", ",", "asthma", ",", "C0152222#ent", "<e2>", "esophageal", "spasm", "myometrial", "hyperactivity", "cerebral", "arterial", "spasm", "and", "migraine", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0152222", "name": "C0152222#ent", "pos": [24, 25]}}
{"token": ["The", "platelet", "preincubation", "with", "propranolol", "(", "beta-adrenoceptor", "antagonist", "prevented", "the", "dopamine", "effect", ",", "whereas", "C0031448#ent", "<e1>", "(", "alpha-adrenoceptor", "antagonist", "failed", "to", "modify", "the", "platelet", "response", "this", "C3536742#ent", "<e2>", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [26, 27]}}
{"token": ["Herpes", "simplex", "virus", "type", "1", "type", "2", "a", "wide", "range", "of", "illnesses", "ranging", "from", "minor", "C0019345#ent", "<e1>", "severe", "necrotising", "encephalitis", "disseminated", "C0243026#ent", "<e2>", "in", "immunocompromised", "patients", "including", "neonates", "."], "h": {"id": "C0019345", "name": "C0019345#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [21, 22]}}
{"token": ["Interestingly", ",", "basal", "c-Fos", "expression", "was", "significantly", "increased", "in", "the", "hippocampus", "of", "C1415307#ent", "<e1>", ",", "but", "not", "C1415306#ent", "<e2>", ",", "receptor", "knockouts", "compared", "to", "wild-type", "mice", "."], "h": {"id": "C1415307", "name": "C1415307#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415306", "name": "C1415306#ent", "pos": [17, 18]}}
{"token": ["A", "77-year-old", "woman", "had", "spontaneous", "C0265123#ent", "<e1>", "caused", "by", "C0519030#ent", "<e2>"], "h": {"id": "C0265123", "name": "C0265123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0519030", "name": "C0519030#ent", "pos": [9, 10]}}
{"token": ["Timely", "and", "proper", "treatment", "of", "C0008354#ent", "<e1>", "will", "avert", "this", "C1848862#ent", "<e2>", ",", "when", "use", "of", "isotonic", "sodium", "bicarbonate", "to", "correct", "acidosis", "may", "be", "very", "helpful", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [10, 11]}}
{"token": ["Kinins", "cleaved", "from", "kininogen", "are", "agonists", "of", "the", "B2R", "and", "must", "be", "processed", "by", "a", "C3265462#ent", "<e1>", "to", "generate", "B1R", "agonists", "des-Arg(9)-bradykinin", "or", "C0164765#ent", "<e2>", "."], "h": {"id": "C3265462", "name": "C3265462#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0164765", "name": "C0164765#ent", "pos": [23, 24]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "NO", "synthase", "inhibition", "with", "C0068821#ent", "<e1>", "L-NAME", ")", "and", "alpha", "2-adrenoreceptor", "stimulation", "with", "C0113293#ent", "<e2>", "(", "Dex", ")", "decreases", "the", "cerebral", "blood", "flow", "CBF", ")", "response", "to", "hypoxia", "."], "h": {"id": "C0068821", "name": "C0068821#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0113293", "name": "C0113293#ent", "pos": [18, 19]}}
{"token": ["The", "authors", "report", "the", "case", "of", "a", "C0155675#ent", "<e1>", "with", "dyspnoea", "and", "C0010520#ent", "<e2>", "in", "a", "young", "adult"], "h": {"id": "C0155675", "name": "C0155675#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0010520", "name": "C0010520#ent", "pos": [12, 13]}}
{"token": ["C0155675#ent", "<e1>", "demonstrated", "angiographically", "in", "8", "patients", "who", "exhibited", "C0010520#ent", "<e2>", "and", "polycythemia", "during", "childhood", "."], "h": {"id": "C0155675", "name": "C0155675#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0010520", "name": "C0010520#ent", "pos": [9, 10]}}
{"token": ["A", "large", "C0155675#ent", "<e1>", "discovered", "in", "a", "patient", "with", "long-standing", "C0010520#ent", "<e2>", ",", "clubbing", "and", "dyspnea", ",", "with", "no", "other", "cardiovascular", "signs", "symptoms", "and", "a", "normal", "chest", "roentgenogram", "the", "time", "of", "cardiac", "catheterization", "pulmonary", "angiography"], "h": {"id": "C0155675", "name": "C0155675#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0010520", "name": "C0010520#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "levels", "of", "the", "phosphorylated", "form", "of", "C0812228#ent", "<e1>", "(", "pAKT", ")", "are", "lower", "in", "C2986618#ent", "<e2>", "than", "in", "SF", "(", "P", "<", "0.0001", ")", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986618", "name": "C2986618#ent", "pos": [17, 18]}}
{"token": ["The", "C0014442#ent", "<e1>", "carrying", "out", "this", "first", "conversion", "step", "is", "C1413855#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413855", "name": "C1413855#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "the", "results", "also", "demonstrated", "that", "the", "expression", "of", "C1705677#ent", "<e1>", "but", "not", "HOXA11", "is", "coregulated", "with", "C1366503#ent", "<e2>", "in", "the", "endometria", "of", "these", "animals", "."], "h": {"id": "C1705677", "name": "C1705677#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366503", "name": "C1366503#ent", "pos": [19, 20]}}
{"token": ["Inhibition", "of", "JNK", "by", "SP600125", "or", "expression", "of", "a", "dominant", "negative", "C1705632#ent", "<e1>", "construct", "abrogated", "the", "migratory", "response", "of", "HBMECs", "to", "C0399440#ent", "<e2>", "."], "h": {"id": "C1705632", "name": "C1705632#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0399440", "name": "C0399440#ent", "pos": [21, 22]}}
{"token": ["Short", "stature", "to", "C3897045#ent", "<e1>", "the", "most", "commonly", "known", "form", "of", "C0878787#ent", "<e2>", "with", "a", "frequency", "greater", "than", "1:1,000", "in", "the", "Caucasian", "population"], "h": {"id": "C3897045", "name": "C3897045#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0878787", "name": "C0878787#ent", "pos": [11, 12]}}
{"token": ["An", "11-year-old", "black", "male", "presenting", "with", "severe", "subacute", "sensory", "ataxia", "unusual", "skin", "hyperpigmentation", "megaloblastic", "anemia", "low", "serum", "B12", "levels", ",", "and", "an", "abnormal", "part", "I", "Schilling", "test", "diagnosed", "with", "C0002892#ent", "<e1>", "the", "context", "of", "a", "C0085409#ent", "<e2>"], "h": {"id": "C0002892", "name": "C0002892#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0085409", "name": "C0085409#ent", "pos": [35, 36]}}
{"token": ["The", "presence", "of", "AADC", "autoantibodies", "patients", "with", "C0085409#ent", "<e1>", "a", "subgroup", "of", "C0002892#ent", "<e2>", "patients", "who", "may", "have", "a", "milder", "atypical", "form", "of", "C0085409#ent", "<e1>", "represent", "a", "distinct", "entity", "."], "h": {"id": "C0002892", "name": "C0002892#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085409", "name": "C0085409#ent", "pos": [7, 8]}}
{"token": ["As", "the", "underlying", "cause", ",", "we", "found", "C0002892#ent", "<e1>", "hemolytic", "activity", "part", "of", "C0085409#ent", "<e2>", "PAS", ")", "type", "II", "."], "h": {"id": "C0002892", "name": "C0002892#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085409", "name": "C0085409#ent", "pos": [13, 14]}}
{"token": ["This", "case", "report", "a", "case", "of", "C0035851#ent", "<e1>", "from", "inadequate", "C0011334#ent", "<e2>", "removal", "and", "orthodontic", "therapy", "in", "maxillary", "right", "lateral", "incisor", "a", "13-yr-old", "female", "."], "h": {"id": "C0035851", "name": "C0035851#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011334", "name": "C0011334#ent", "pos": [10, 11]}}
{"token": ["Although", "extraction", "of", "the", "upper", "central", "incisors", "very", "rare", "because", "of", "their", "esthetical", "importance", "they", "are", "sometimes", "extracted", "when", "impaction", ",", "C0035851#ent", "<e1>", "abnormal", "morphology", ",", "severe", "C0011334#ent", "<e2>", "and/or", "trauma", "are", "involved", "."], "h": {"id": "C0035851", "name": "C0035851#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0011334", "name": "C0011334#ent", "pos": [27, 28]}}
{"token": ["C0017868#ent", "<e1>", "and", "glycerol", "3-phosphate", "uptake", "in", "Bacillus", "subtilis", "not", "involve", "the", "C0031727#ent", "<e2>"], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}}
{"token": ["The", "first", "step", "in", "the", "dissimilation", "of", "C0017868#ent", "<e1>", "requires", "a", "C0031727#ent", "<e2>", ",", "and", "the", "initial", "process", "of", "utilization", "of", "l-alpha-glycerophosphate", "involves", "an", "active", "transport", "system"], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["The", "presence", "in", "this", "organism", "of", "the", "phosphoenolpyruvate", ":", "sugar", "phosphotransferase", "system", "fructose", ",", "but", "not", "C0017868#ent", "<e1>", ",", "as", "well", "as", "C0031727#ent", "<e2>", "for", "fructose", "and", "C0017868#ent", "<e1>", "was", "demonstrated", "."], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [16, 17]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}}
{"token": ["Additionally", ",", "the", "messenger", "ribonucleic", "acids", "mRNAs", ")", "for", "C1709394#ent", "<e1>", "and", "PDGF-B", ",", "PDGF", "receptor-alpha", "and", "-beta", ",", "and", "C1334089#ent", "<e2>", "were", "investigated", "by", "in", "situ", "hybridization", "alveolar", "macrophages", "lung", "tissues", "patients", "with", "interstitial", "lung", "disease"], "h": {"id": "C1709394", "name": "C1709394#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [20, 21]}}
{"token": ["Serologic", "tests", "C0025229#ent", "<e1>", ",", "leptospirosis", ",", "scrub", ",", "murine", "and", "C0041473#ent", "<e2>", "psittacosis", "were", "all", "negative", "."], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041473", "name": "C0041473#ent", "pos": [11, 12]}}
{"token": ["Because", "all", "three", "genes", "hybridized", "to", "DNA", "fragments", "different", "lengths", "it", "seems", "unlikely", "that", "the", "C0017337#ent", "<e1>", "for", "17-HSD", "is", "located", "very", "close", "to", "C1710294#ent", "<e2>", "and", "ERBB2", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1710294", "name": "C1710294#ent", "pos": [24, 25]}}
{"token": ["These", "results", "show", "that", "C0238062#ent", "<e1>", "be", "a", "manifestation", "associated", "with", "C2699843#ent", "<e2>", ",", "and", "indicate", "that", "aganglionosis", "is", "not", "the", "only", "mechanism", "underlying", "the", "intestinal", "dysfunction", "patients", "with", "SOX10", "mutations", "."], "h": {"id": "C0238062", "name": "C0238062#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2699843", "name": "C2699843#ent", "pos": [11, 12]}}
{"token": ["We", "checked", "the", "consistency", "of", "the", "estimates", "for", "uPA", "and", "C1705527#ent", "<e1>", "for", "relapse-free", "survival", "RFS", ")", "and", "C0024796#ent", "<e2>", "exploring", "possible", "sources", "of", "heterogeneity", "."], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [18, 19]}}
{"token": ["When", "given", "in", "combination", "with", "C1417807#ent", "<e1>", ",", "C0032912#ent", "<e2>", "blunted", "the", "natriuretic", "effect", "C1417807#ent", "<e1>", "from", "130", "%", "to", "35", "%", "(", "P", "less", "than", "0.01", ")", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [5, 6]}}
{"token": ["C1366463#ent", "<e1>", "induces", "uPA", "and", "gelatinase", ",", "C3540790#ent", "<e2>", "which", "play", "a", "crucial", "role", "in", "trophoblastic", "invasion"], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [7, 8]}}
{"token": ["The", "effect", "of", "five", "days", "treatment", "with", "C0039663#ent", "<e1>", "(", "THC", ")", "was", "examined", "on", "prodynorphin", "(", "C1418447#ent", "<e2>", ")", "and", "proenkephalin", "(", "PENK", ")", "gene", "expression", "the", "spinal", "cord", "male", "rats", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418447", "name": "C1418447#ent", "pos": [17, 18]}}
{"token": ["Antinociceptive", "dose-response", "curves", "were", "constructed", "for", "C0039663#ent", "<e1>", "WIN", "55,212", "-", "2", "in", "C1418447#ent", "<e2>", "knock-out", "mice", "in", "wild-type", "littermates", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418447", "name": "C1418447#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "five", "days", "treatment", "with", "C0039663#ent", "<e1>", "(", "THC", ")", "was", "examined", "on", "C1418447#ent", "<e2>", "(", "PDYN", ")", "and", "proenkephalin", "(", "PENK", ")", "gene", "expression", "the", "spinal", "cord", "male", "rats", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418447", "name": "C1418447#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "TIMP-2", "and", "mutant", "Ala+TIMP-2", ",", "which", "is", "devoid", "of", "C0919336#ent", "<e1>", "inhibitory", "activity", "block", "hMVEC", "migration", "in", "response", "to", "C1823619#ent", "<e2>", "stimulation", "."], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1823619", "name": "C1823619#ent", "pos": [22, 23]}}
{"token": ["C0751781#ent", "<e1>", "an", "autosomal", "dominant", "neurodegenerative", "disease", "by", "various", "combinations", "of", "C0007758#ent", "<e2>", ",", "choreoathetosis", ",", "myoclonus", ",", "epilepsy", ",", "and", "dementia", "as", "well", "as", "a", "wide", "range", "of", "ages", "at", "onset", "."], "h": {"id": "C0751781", "name": "C0751781#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [11, 12]}}
{"token": ["In", "order", "to", "identify", "C0751781#ent", "<e1>", "patients", "in", "Taiwan", ",", "we", "screened", "six", "autosomal", "dominant", "C0007758#ent", "<e2>", "patients", "without", "expansion", "in", "known", "spinocerebellar", "ataxia", "genes"], "h": {"id": "C0751781", "name": "C0751781#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [15, 16]}}
{"token": ["Montelukast", "is", "probably", "the", "most", "useful", "C0595726#ent", "<e1>", "for", "continuous", "treatment", "exercise-induced", "asthma", "performing", "as", "well", "as", "C0073992#ent", "<e2>", "without", "inducing", "any", "tolerance", "."], "h": {"id": "C0595726", "name": "C0595726#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0073992", "name": "C0073992#ent", "pos": [17, 18]}}
{"token": ["C3884445#ent", "<e1>", "is", "a", "C0018296#ent", "<e2>", "that", "is", "critical", "for", "endocytosis", "."], "h": {"id": "C3884445", "name": "C3884445#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [4, 5]}}
{"token": ["In", "addition", ",", "Fab", "fragments", "C3889128#ent", "<e1>", "and", "cytochrome", "b559", "used", "to", "localize", "those", "two", "C1305923#ent", "<e2>", ",", "and", "thus", "the", "reaction", "center", "within", "the", "PS", "II", "complex"], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [15, 16]}}
{"token": ["Binding", "of", "atrazine", "to", "the", "C3889128#ent", "<e1>", "necessary", "to", "protect", "the", "C1305923#ent", "<e2>", "as", "shown", "with", "PS", "II", "fragments", "from", "an", "atrazine-resistant", "biotype", "of", "Chenopodium", "album", "are", "protected", "by", "diuron", "not", "by", "atrazine", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [11, 12]}}
{"token": ["Arginine", "kinase", "AK", ")", "from", "the", "foot", "of", "the", "razor", "clam", "Ensis", "directus", "of", "two", "full-length", "AK", "domains", ",", "C3889128#ent", "<e1>", "D2", ",", "fused", "in", "a", "C1305923#ent", "<e2>"], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [26, 27]}}
{"token": ["IRp60", "is", "C0669365#ent", "<e1>", "expressed", "on", "mast", "cells", "is", "down-regulated", "in", "vitro", "the", "C0059409#ent", "<e2>", "basic", "protein", "and", "eosinophil-derived", "neurotoxin"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0059409", "name": "C0059409#ent", "pos": [13, 14]}}
{"token": ["Loss", "of", "C1420718#ent", "<e1>", "catalytic", "activity", "by", "diamide-GSH", "is", "partially", "recovered", "by", "DTT", "and", "C1870389#ent", "<e2>", ",", "whereas", "the", "disulfide", "linkage", "GSH", "with", "C1420718#ent", "<e1>", "is", "completely", "reversed", "by", "both", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1870389", "name": "C1870389#ent", "pos": [14, 15]}}
{"token": ["Since", "LAK", "cells", "have", "C0003392#ent", "<e1>", "are", "produced", "in", "response", "to", "stimulation", "with", "C1522405#ent", "<e2>", ",", "we", "investigated", "whether", "LAK", "killing", "might", "be", "more", "readily", "demonstrable", "in", "very", "young", "children", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [13, 14]}}
{"token": ["The", "C0003392#ent", "<e1>", "efficacy", "of", "C1522405#ent", "<e2>", "IL-2", ")", "in", "autochthonous", "methylnitrosourea-induced", "mammary", "carcinoma", "and", "in", "acetoxymethyl-methyl-nitrosamine-induced", "colorectal", "carcinoma", "of", "Sprague", "Dawley", "rats", "been", "investigated", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [5, 6]}}
{"token": ["Western", "blots", "that", ",", "in", "me(v", ")", "whole", "cell", "lysates", "there", "were", "reduced", "levels", "of", "C1335610#ent", "<e1>", "and", "RelB", "proteins", "and", "increased", "levels", "of", "p50", "and", "C1704703#ent", "<e2>", "."], "h": {"id": "C1335610", "name": "C1335610#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704703", "name": "C1704703#ent", "pos": [26, 27]}}
{"token": ["Electrophoretic", "mobility", "shift", "analysis", "that", "NF-kappa", "B", "p65", "C1335610#ent", "<e1>", ")", "and", "p50", ",", "but", "not", "p52", "or", "C1704703#ent", "<e2>", ",", "bind", "specifically", "to", "the", "NF-kappa", "B", "site", "the", "SAA2", "promoter", "in", "response", "to", "IL-1", "stimulation", "."], "h": {"id": "C1335610", "name": "C1335610#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704703", "name": "C1704703#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", ",", "squelching", "experiments", "revealed", "that", "both", "TADs", "of", "C1335610#ent", "<e1>", ",", "as", "well", "as", "the", "related", "C1704703#ent", "<e2>", "compete", "for", "the", "same", "cofactor(s", ")", "mediating", "transactivation", "."], "h": {"id": "C1335610", "name": "C1335610#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704703", "name": "C1704703#ent", "pos": [19, 20]}}
{"token": ["No", "C0007074#ent", "<e1>", "or", "D-alanine", "carboxypeptidase", "activity", "was", "detected", "in", "mixtures", "of", "high", "molecular", "weight", "C0070235#ent", "<e2>", "B.", "subtilis", ",", "B.", "stearothermophilus", "or", "Staphylococcus", "aureus"], "h": {"id": "C0007074", "name": "C0007074#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0070235", "name": "C0070235#ent", "pos": [15, 16]}}
{"token": ["The", "C0007074#ent", "<e1>", "(", "TP", ")", "activity", "of", "C0070235#ent", "<e2>", "PBPs", ")", ",", "target", "of", "the", "beta-lactam", "antibiotics", "is", "a", "well-validated", "antibacterial", "drug", "target", "."], "h": {"id": "C0007074", "name": "C0007074#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0070235", "name": "C0070235#ent", "pos": [8, 9]}}
{"token": ["New", "drugs", "including", "those", "targeting", "the", "epidermal", "growth", "factor", "receptor", "p53", "gene", "RAS", "protein", "modification", ",", "the", "C0208355#ent", "<e1>", ",", "vascular", "endothelial", "growth", "factor", "cyclooxigenase-2", "and", "other", "molecular", "pathways", "are", "promising", "C0991617#ent", "<e2>", "for", "management", "of", "head-neck", "cancer", "."], "h": {"id": "C0208355", "name": "C0208355#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [31, 32]}}
{"token": ["Wnt", "stabilizes", "cytosolic", "C1332803#ent", "<e1>", ",", "which", "then", "binds", "to", "TCF", "and", "activates", "C0812327#ent", "<e2>"], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [13, 14]}}
{"token": ["Six", "pony", "foals", ",", "experimentally", "infected", "with", "equine", "herpesvirus", "1", "C0672504#ent", "<e1>", ")", ",", "were", "studied", "for", "their", "lymphocyte", "responses", "to", "C0672504#ent", "<e1>", "and", "phytohemagglutinin", "(", "C0030779#ent", "<e1>", ")", "stimulations", "."], "h": {"id": "C0672504", "name": "C0672504#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [26, 27]}}
{"token": ["Finally", ",", "effects", "of", "NE", "could", "still", "be", "produced", "in", "a", "C0022471#ent", "<e1>", "acid-treated", "hippocampus", "where", "most", "neurons", "were", "previously", "destroyed", "by", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [23, 24]}}
{"token": ["Incubation", "of", "AEC", "with", "DA", "resulted", "in", "rapid", "and", "transient", "stimulation", "of", "C1370600#ent", "<e1>", "activity", ",", "which", "was", "mediated", "by", "C0080058#ent", "<e2>", "the", "serine/threonine", "kinase", "Raf-1"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [20, 21]}}
{"token": ["These", "data", "suggest", "that", "Ang", "II-induced", "C1370600#ent", "<e1>", "activation", "through", "the", "Ang", "II", "type", "1", "receptor", "be", "mediated", "by", "C0080058#ent", "<e2>", "through", "a", "currently", "unidentified", "tyrosine", "kinase", "lies", "downstream", "of", "Gq-coupled", "Ca2+/calmodulin", "signals", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [19, 20]}}
{"token": ["A", "single", "mutation", "in", "C0949782#ent", "<e1>", ",", "but", "not", "C1336767#ent", "<e2>", "caused", "a", "two-", "to", "fourfold", "increase", "in", "the", "MIC", "."], "h": {"id": "C0949782", "name": "C0949782#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [9, 10]}}
{"token": ["C1333340#ent", "<e1>", "blocking", "by", "C0360097#ent", "<e2>", "results", "in", "a", "decrease", "of", "the", "nociceptive", "activity", "spinal", "dorsal", "horn", "neurones", "whereas", "stimulation", "by", "glutamate", "has", "the", "opposite", "effect", "."], "h": {"id": "C1333340", "name": "C1333340#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0360097", "name": "C0360097#ent", "pos": [4, 5]}}
{"token": ["C1412719#ent", "<e1>", "-", "7", "cells", "were", "found", "to", "express", "CNTFR", "alpha", "C1334339#ent", "<e2>", "and", "gp130", "genes", "as", "shown", "by", "reverse", "transcription-polymerase", "chain", "reaction", "analysis", "and", "the", "corresponding", "proteins", ",", "analysed", "by", "immunofluorescence", "and", "western", "blot"], "h": {"id": "C1412719", "name": "C1412719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334339", "name": "C1334339#ent", "pos": [11, 12]}}
{"token": ["These", "data", "suggest", "that", "only", "C0162357#ent", "<e1>", "decreases", "inflammation", "and", "local", "bone", "deformation", ",", "while", "both", "C2740858#ent", "<e2>", "inhibit", "the", "arthritis-related", "decreases", "in", "systemic", "bone", "mass", "bone", "strength"], "h": {"id": "C0162357", "name": "C0162357#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2740858", "name": "C2740858#ent", "pos": [16, 17]}}
{"token": ["C0040207#ent", "<e1>", "(", "inhibitor", "of", "ADP-induced", "platelet", "aggregation", ")", "=", "C0012582#ent", "<e2>", "(", "adenosine", "uptake", "inhibitor", ")", ">", "aspirin", "(", "cyclooxygenase", "inhibitor", "."], "h": {"id": "C0040207", "name": "C0040207#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012582", "name": "C0012582#ent", "pos": [10, 11]}}
{"token": ["Hepatic", "cytochrome", "P450", "C0534137#ent", "<e1>", ")", "content", "and", "C0042523#ent", "<e2>", "were", "also", "measured", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [8, 9]}}
{"token": ["We", "have", "also", "found", "an", "interrelationship", "between", "C3273406#ent", "<e1>", "ET-1", "because", "the", "C1414262#ent", "<e2>", "antagonist", "diminished", "CTGF", "upregulation", "caused", "by", "C3273406#ent", "<e1>"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414262", "name": "C1414262#ent", "pos": [12, 13]}}
{"token": ["The", "loop", "diuretic", "C0016860#ent", "<e1>", ",", "and", "the", "anti-inflammatory", "drug", "C0068483#ent", "<e2>", "which", "both", "inhibit", "MBS-induced", "bronchoconstriction", "in", "patients", "with", "asthma", ",", "were", "also", "without", "effect", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0068483", "name": "C0068483#ent", "pos": [10, 11]}}
{"token": ["Finally", ",", "we", "showed", "that", "estrogen", "increased", "GSH", "content", ",", "C1705766#ent", "<e1>", "and", "GR", "activities", ",", "and", "C0023521#ent", "<e2>", "expression", "in", "the", "liver", "of", "both", "male", "and", "female", "mice", "."], "h": {"id": "C1705766", "name": "C1705766#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023521", "name": "C0023521#ent", "pos": [17, 18]}}
{"token": ["A", "multiplex", "polymerase", "chain", "reaction", "used", "to", "amplify", "potential", "virulence", "genes", "C1419277#ent", "<e1>", ",", "gel", "E", "cylA", ",", "esp", "and", "C1705672#ent", "<e2>", ")", "in", "VREfm", "isolates", "obtained", "from", "an", "Australian", "population", "haematology", "patients", "."], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705672", "name": "C1705672#ent", "pos": [20, 21]}}
{"token": ["Multiplex", "PCR", "used", "to", "detect", "the", "presence", "of", "the", "enterococcal", "virulence", "genes", "C1419277#ent", "<e1>", ",", "gelE", ",", "cylA", ",", "esp", ",", "and", "C1705672#ent", "<e2>", "."], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705672", "name": "C1705672#ent", "pos": [22, 23]}}
{"token": ["The", "EIA", "showed", "the", "binding", "of", "anti-ID-antibodies", "isolated", "from", "mice", "serum", "both", "MAb", "inducing", "their", "synthesis", "and", "to", "C0360390#ent", "<e1>", "serum", "antibodies", "caws", "with", "C0041296#ent", "<e2>", "."], "h": {"id": "C0360390", "name": "C0360390#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [24, 25]}}
{"token": ["The", "results", "of", "large", "double-blind", "trials", "in", "patients", "with", "C0014869#ent", "<e1>", "compare", "favorably", "with", "those", "reported", "using", "cimetidine", "and", "C0034665#ent", "<e2>", "."], "h": {"id": "C0014869", "name": "C0014869#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [19, 20]}}
{"token": ["However", ",", "none", "of", "these", "reagents", "affected", "expression", "of", "idiotypic", "IgM", "at", "the", "cell", "surface", "the", "conditions", "used", ",", "indicating", "that", "whole", "C1706005#ent", "<e1>", "is", "not", "interacting", "directly", "with", "the", "C0524889#ent", "<e2>"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0524889", "name": "C0524889#ent", "pos": [30, 31]}}
{"token": ["If", "four", "applications", "of", "mezerein", "were", "preceded", "by", "four", "applications", "of", "C0256103#ent", "<e1>", ",", "then", "the", "C1334899#ent", "<e2>", "level", "was", "similar", "to", "that", "after", "C0256103#ent", "<e1>", "alone", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [16, 17]}}
{"token": ["Although", ",", "C0256103#ent", "<e1>", "can", "cause", "a", "decrease", "in", "the", "number", "of", "C1334899#ent", "<e2>", "promotion", ",", "FA", "can", "effectively", "prevent", "this", "loss", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [12, 13]}}
{"token": ["It", "inhibits", "C0164707#ent", "<e1>", "TFPI", ")", "activity", "and", "accelerates", "clotting", "of", "human", "C1366370#ent", "<e2>", "B", "plasma"], "h": {"id": "C0164707", "name": "C0164707#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [12, 13]}}
{"token": ["In", "the", "presence", "of", "C0164707#ent", "<e1>", "no", "explosive", "thrombin", "generation", "was", "observed", "when", "C1366370#ent", "<e2>", "omitted", "from", "reactions", "initiated", "by", "factor", "VIIa"], "h": {"id": "C0164707", "name": "C0164707#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [13, 14]}}
{"token": ["It", "is", "concluded", "that", "C0011311#ent", "<e1>", "cause", "hepatic", "injury", "transaminase", "elevation", "to", "that", "in", "patients", "with", "conventional", "C0042721#ent", "<e2>"], "h": {"id": "C0011311", "name": "C0011311#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [17, 18]}}
{"token": ["The", "organization", "of", "gene", "1", "gene", "2", "C1425046#ent", "<e1>", "resembles", "the", "organization", "of", "C0017337#ent", "<e2>", "in", "the", "pac/cos", "region", "of", "different", "Escherichia", "coli", "double-stranded", "DNA", "phages"], "h": {"id": "C1425046", "name": "C1425046#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["C0035242#ent", "<e1>", "severe", "kidney", "disease", "hypertension", ",", "and", "C0029408#ent", "<e2>", "were", "notably", "absent", "."], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [8, 9]}}
{"token": ["Since", "these", "sperm", "characteristics", "were", "similar", "to", "those", "found", "in", "C0166429#ent", "<e1>", "sperm", ",", "we", "investigated", "the", "interaction", "of", "C1413483#ent", "<e2>", "with", "C0166429#ent", "<e1>"], "h": {"id": "C0166429", "name": "C0166429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413483", "name": "C1413483#ent", "pos": [19, 20]}}
{"token": ["Moreover", ",", "we", "identified", "C0072074#ent", "<e1>", "a", "potential", "binding", "partner", "for", "C1428955#ent", "<e2>", "by", "yeast", "two-hybrid", "screening", "."], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428955", "name": "C1428955#ent", "pos": [11, 12]}}
{"token": ["Treatment", "of", "C0003873#ent", "<e1>", "RA", ")", "with", "tumor", "necrosis", "factor", "agents", ",", "including", "C0717758#ent", "<e2>", "and", "infliximab", ",", "has", "resulted", "in", "reductions", "in", "the", "radiographic", "progression", "of", "RA", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0717758", "name": "C0717758#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "peptides", "on", "ODC", "and", "S-adenosylmethionine", "(", "C3539529#ent", "<e1>", ")", "activities", "(", "key", "C3541394#ent", "<e2>", "in", "polyamine", "biosynthesis", "in", "isolated", "enterocytes", "is", "unknown", "."], "h": {"id": "C3539529", "name": "C3539529#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}}
{"token": ["Ornithine", "decarboxylase", "ODC", ")", "and", "S-adenosylmethionine", "decarboxylase", "C3539529#ent", "<e1>", ")", "are", "two", "key", "C3541394#ent", "<e2>", "in", "polyamine", "(", "PA", ")", "biosynthesis", "and", "their", "inhibition", "leads", "to", "PA", "pool", "depletion", "and", "cell", "growth", "arrest"], "h": {"id": "C3539529", "name": "C3539529#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["C0031935#ent", "<e1>", ",", "pipamperone", ",", "aceperon", ",", "C0066477#ent", "<e2>", ",", "and", "clotiapine", "were", "atypical", "in", "single-dose", "studies", ",", "clopenthixol", "in", "repeated-dose", "studies", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0066477", "name": "C0066477#ent", "pos": [7, 8]}}
{"token": ["The", "results", "demonstrate", "the", "C0003364#ent", "<e1>", "'", "slow", "channel", "inhibitors", "'", "as", "represented", "by", "C0280858#ent", "<e2>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [14, 15]}}
{"token": ["An", "integrated", "mathematical", "method", "describing", "antihypertensive", "response", "which", "incorporates", "both", "pharmacokinetic", "and", "pharmacodynamic", "information", "has", "been", "used", "to", "investigate", "the", "variability", "in", "C0003364#ent", "<e1>", "nifedipine", "and", "C0280858#ent", "<e2>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [26, 27]}}
{"token": ["Progressive", "supranuclear", "palsy", "PSP", ")", "is", "a", "sporadic", "multisystem", "neurodegenerative", "disorder", "is", "one", "of", "the", "major", "causes", "of", "C0030567#ent", "<e1>", ",", "which", "shares", "common", "biochemical", "and", "genetic", "features", "corticobasal", "degeneration", "C0006982#ent", "<e2>", ")", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0006982", "name": "C0006982#ent", "pos": [30, 31]}}
{"token": ["In", "a", "clinical", "investigation", "the", "treatment", "of", "C0030567#ent", "<e1>", "is", "shown", "that", "a", "combination", "of", "L-dopa", "with", "decarboxylase", "inhibitor", "C0006982#ent", "<e2>", ")", "shows", "advantages", "compared", "to", "treatment", "with", "L-dopa", "alone", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0006982", "name": "C0006982#ent", "pos": [19, 20]}}
{"token": ["Very", "small", "doses", "levodopa", "induced", "an", "improvement", "in", "C0030567#ent", "<e1>", "when", "patients", "were", "concomitantly", "taking", "C0006982#ent", "<e2>", "and", "tranylcypromine", ",", "but", "adverse", "reactions", "prominent", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0006982", "name": "C0006982#ent", "pos": [15, 16]}}
{"token": ["For", "etoposide", "(", "VP-16", ")", ",", "increased", "expression", "of", "C1704939#ent", "<e1>", "or", "MRP", "and", "alterations", "in", "C1172436#ent", "<e2>", "been", "shown", "to", "confer", "tolerance", "."], "h": {"id": "C1704939", "name": "C1704939#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1172436", "name": "C1172436#ent", "pos": [16, 17]}}
{"token": ["Human", "variants", "in", "SCN5A", "(", "encodes", "C3538758#ent", "<e1>", ")", "that", "block", "C3538758#ent", "<e1>", "interaction", "with", "C1412404#ent", "<e1>", "lead", "to", "loss", "of", "C3538758#ent", "<e1>", "membrane", "expression", "and", "Brugada", "syndrome"], "h": {"id": "C1412404", "name": "C1412404#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3538758", "name": "C3538758#ent", "pos": [6, 7]}}
{"token": ["We", "define", "the", "structural", "requirements", "C1412404#ent", "<e1>", "for", "C3538758#ent", "<e2>", "interactions", "and", "demonstrate", "that", "loss", "of", "C3538758#ent", "<e2>", "targeting", "is", "caused", "by", "the", "loss", "of", "direct", "Na(v)1.5-ankyrin-G", "interaction", "."], "h": {"id": "C1412404", "name": "C1412404#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538758", "name": "C3538758#ent", "pos": [8, 9]}}
{"token": ["Cardiomyocytes", "with", "reduced", "C1412404#ent", "<e1>", "display", "reduced", "C3538758#ent", "<e2>", "expression", ",", "abnormal", "Na(v)1.5", "membrane", "targeting", ",", "and", "reduced", "Na(+", ")", "channel", "current", "density", "."], "h": {"id": "C1412404", "name": "C1412404#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538758", "name": "C3538758#ent", "pos": [7, 8]}}
{"token": ["The", "E1053", "K", "mutation", "abolishes", "binding", "of", "C3538758#ent", "<e1>", "to", "C1412404#ent", "<e2>", ",", "and", "also", "prevents", "accumulation", "of", "C3538758#ent", "<e1>", "at", "cell", "surface", "in", "ventricular", "cardiomyocytes"], "h": {"id": "C1412404", "name": "C1412404#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3538758", "name": "C3538758#ent", "pos": [7, 8]}}
{"token": ["Conclusive", "evidence", "now", "provided", "that", "direct", "interaction", "between", "C3538758#ent", "<e1>", "and", "C1412404#ent", "<e2>", "is", "necessary", "for", "the", "expression", "of", "C3538758#ent", "<e1>", "at", "the", "cardiomyocyte", "cell", "surface", "."], "h": {"id": "C1412404", "name": "C1412404#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538758", "name": "C3538758#ent", "pos": [8, 9]}}
{"token": ["In", "future", ",", "derivatives", "of", "HIV", "protease", "inhibitors", "being", "more", "specific", "for", "the", "fungal", "C1822731#ent", "<e1>", ",", "may", "form", "an", "alternative", "in", "the", "treatment", "of", "C0006848#ent", "<e2>", "insensitive", "to", "currently", "available", "antimycotics", "."], "h": {"id": "C1822731", "name": "C1822731#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006848", "name": "C0006848#ent", "pos": [25, 26]}}
{"token": ["In", "contrast", ",", "overexpression", "of", "constitutively", "active", "C1307053#ent", "<e1>", "inhibited", "apoptosis", "suppressing", "TGF-beta1-induced", "activation", "p38", ",", "JNK", "and", "C0010656#ent", "<e2>", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [18, 19]}}
{"token": ["An", "additional", "set", "of", "residues", "located", "on", "the", "surface", "of", "the", "C-terminal", "fibronectin", "type", "III", "domain", "the", "C1704822#ent", "<e1>", "binding", "site", "a", "role", "in", "the", "procoagulant", "activity", "C1705156#ent", "<e2>", "but", "are", "not", "involved", "in", "C1704822#ent", "<e1>", "binding", "."], "h": {"id": "C1704822", "name": "C1704822#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705156", "name": "C1705156#ent", "pos": [27, 28]}}
{"token": ["The", "degree", "of", "enhancement", "of", "C1704822#ent", "<e1>", "activity", "by", "C1705156#ent", "<e2>", "varied", "from", "12-fold", "at", "pH", "7.5", "to", "73-fold", "at", "pH", "9.9", "."], "h": {"id": "C1704822", "name": "C1704822#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705156", "name": "C1705156#ent", "pos": [9, 10]}}
{"token": ["Once", "the", "lineage", "is", "established", "by", "morphologic", "criteria", "the", "eosinophilopoietic", "cytokines", "mediate", "upregulation", "of", "C1412362#ent", "<e1>", "and", "LTC4S", ",", "members", "of", "a", "newly", "recognized", "C1335597#ent", "<e2>", "and", "of", "5-LO", ",", "during", "ongoing", "cell", "maturation"], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335597", "name": "C1335597#ent", "pos": [24, 25]}}
{"token": ["C1367551#ent", "<e1>", "or", "8-bromo-cAMP", "treatment", "induced", "C1335224#ent", "<e2>", "mRNA", "accumulation", ",", "which", "was", "negligible", "in", "untreated", "cells", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335224", "name": "C1335224#ent", "pos": [6, 7]}}
{"token": ["Treatment", "with", "the", "synthetic", "glucocorticoid", "hormone", "dexamethasone", ",", "was", "found", "to", "inhibit", "C1367551#ent", "<e1>", "induction", "of", "C1335224#ent", "<e2>", "enzyme", "activity", "as", "much", "as", "80", "%", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335224", "name": "C1335224#ent", "pos": [16, 17]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "human", "eukaryotic", "initiation", "factor", "4A", "C1414347#ent", "<e2>", ")", "is", "located", "on", "chromosome", "17p13", "667", "bp", "upstream", "from", "the", "C0017337#ent", "<e1>", "encoding", "the", "macrophage", "endosomal", "protein", "CD68", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414347", "name": "C1414347#ent", "pos": [9, 10]}}
{"token": ["Phenylketonuria", "(", "C0031485#ent", "<e1>", ")", "is", "a", "C0019247#ent", "<e2>", "autosomal", "recessive", "inheritance", "."], "h": {"id": "C0031485", "name": "C0031485#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["Immobilization", "increased", "the", "ED50", "of", "the", "C1254351#ent", "<e1>", "not", "only", "in", "muscles", "from", "the", "C0030196#ent", "<e2>", "in", "the", "cast", "but", "also", "those", "from", "contralateral", "forelimbs", "from", "hindlimbs", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [14, 15]}}
{"token": ["Injection", "of", "each", "C1254351#ent", "<e1>", "elicited", "a", "unique", "posture", "or", "combination", "of", "C0030196#ent", "<e2>", "movements", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [12, 13]}}
{"token": ["An", "unusual", "feature", "of", "PfCPK", "is", "that", "its", "carboxyl-terminal", "segment", "homology", "to", "the", "C0059036#ent", "<e1>", "hand", "calcium-binding", "proteins", "for", "example", "34", "%", "C2917660#ent", "<e2>", "to", "chicken", "fast", "skeletal", "muscle", "troponin", "C", "35", "%", "C2917660#ent", "<e2>", "to", "human", "calmodulin", "."], "h": {"id": "C0059036", "name": "C0059036#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [22, 23]}}
{"token": ["The", "identification", "of", "frameshift", "and", "nonsense", "suppressor", "mutations", "C0059036#ent", "<e1>", "a", "role", "for", "this", "protein", "in", "limiting", "C2917660#ent", "<e2>", "misincorporation", "and", "reading", "frame", "errors"], "h": {"id": "C0059036", "name": "C0059036#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [17, 18]}}
{"token": ["Raclopride", "and", "C0073047#ent", "<e1>", ",", "which", "are", "reported", "to", "be", "selective", "C3850099#ent", "<e2>", "are", "currently", "under", "clinical", "investigation", "antipsychotic", "drugs"], "h": {"id": "C0073047", "name": "C0073047#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [11, 12]}}
{"token": ["The", "self-administration", "liability", "of", "C0073047#ent", "<e1>", ",", "a", "specific", "C3850099#ent", "<e2>", "by", "laboratory", "rats", "was", "evaluated", "using", "an", "intravenous", "self-administration", "paradigm", "."], "h": {"id": "C0073047", "name": "C0073047#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [9, 10]}}
{"token": ["An", "in", "vitro", "assay", "revealed", "C1419741#ent", "<e1>", ",", "a", "major", "target", "of", "C1419748#ent", "<e2>", ",", "to", "increase", "phosphorylation", "of", "Akt", "."], "h": {"id": "C1419741", "name": "C1419741#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419748", "name": "C1419748#ent", "pos": [12, 13]}}
{"token": ["Likewise", ",", "inhibition", "of", "C1419748#ent", "<e1>", "activity", "and", "C1419741#ent", "<e2>", "phosphorylation", "by", "overexpression", "of", "dominant-negative", "C1419748#ent", "<e1>", "mutants", "failed", "to", "suppress", "the", "translational", "activation", "of", "TOP", "mRNAs", "in", "amino", "acid-refed", "cells", "."], "h": {"id": "C1419741", "name": "C1419741#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419748", "name": "C1419748#ent", "pos": [4, 5]}}
{"token": ["EFV", "is", "a", "mixed", "inducer/inhibitor", "of", "cytochrome", "P450", "CYP", ")", "3A4", "C1412365#ent", "<e1>", "and", "may", "interact", "with", "C0063164#ent", "<e2>", "HMG-CoA", ")", "reductase", "inhibitors", "that", "are", "primarily", "metabolized", "via", "CYP3A4", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0063164", "name": "C0063164#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "triiodothyronine", "(", "T3", ")", "on", "Na+,K(+)-ATPase", "activity", "of", "K562", "human", "erythroleukemic", "cell", "studied", "to", "understand", "why", "the", "C0001479#ent", "<e1>", "activity", "is", "decreased", "in", "C0020550#ent", "<e2>", "."], "h": {"id": "C0001479", "name": "C0001479#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [26, 27]}}
{"token": ["Newer", "antidepressants", "such", "as", "selective", "serotonin", "(", "5-hydroxytryptamine", ";", "5-HT", ")", "C0242980#ent", "<e1>", "SSRIs", ")", "and", "reversible", "inhibitors", "of", "C0026455#ent", "<e2>", "not", "been", "shown", "to", "have", "negative", "effects", "on", "cognition", "."], "h": {"id": "C0242980", "name": "C0242980#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026455", "name": "C0026455#ent", "pos": [19, 20]}}
{"token": ["The", "addition", "of", "cyclopamine", ",", "an", "inhibitor", "of", "Shh", "signaling", ",", "to", "NIH3T3", "cells", ",", "suppressed", "the", "regulation", "of", "Ang-1", "and", "C0540511#ent", "<e1>", "mRNA", "levels", "in", "the", "presence", "of", "C0672708#ent", "<e2>", "."], "h": {"id": "C0540511", "name": "C0540511#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0672708", "name": "C0672708#ent", "pos": [29, 30]}}
{"token": ["The", "main", "C0162667#ent", "<e1>", "were", "Teladorsagia", ",", "Haemonchus", ",", "Trichostrongylus", "and", "C0026414#ent", "<e2>", ",", "with", "Nematodirus", ",", "Cooperia", ",", "Oesophagostomum", "and", "Trichuris", "occasionally", "recorded", "."], "h": {"id": "C0162667", "name": "C0162667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026414", "name": "C0026414#ent", "pos": [11, 12]}}
{"token": ["The", "C1428159#ent", "<e1>", "activity", "in", "the", "four", "classes", "of", "C0022806#ent", "<e2>", "did", "not", "differ", "."], "h": {"id": "C1428159", "name": "C1428159#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022806", "name": "C0022806#ent", "pos": [9, 10]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "compare", "the", "incidence", "of", "spinal", "hypotension", "induced", "by", "C0887621#ent", "<e1>", "and", "lidocaine", "in", "C0030612#ent", "<e2>", "undergoing", "cesarean", "section"], "h": {"id": "C0887621", "name": "C0887621#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030612", "name": "C0030612#ent", "pos": [20, 21]}}
{"token": ["The", "addition", "of", "progesterone", "to", "plasma", "samples", "of", "non-pregnant", "volunteers", "not", "influence", "the", "free", "fraction", "C0887621#ent", "<e1>", ",", "whereas", "the", "addition", "of", "alpha-1-acid", "glycoprotein", "the", "plasma", "of", "C0030612#ent", "<e2>", "decreased", "the", "free", "fraction", "."], "h": {"id": "C0887621", "name": "C0887621#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030612", "name": "C0030612#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "organic", "anion", "transporter", "3", "C1412610#ent", "<e1>", ")", "is", "expressed", "at", "the", "C1801950#ent", "<e2>", "and", "mediates", "the", "efflux", "transport", "homovanillic", "acid", "a", "dopamine", "metabolite", "."], "h": {"id": "C1412610", "name": "C1412610#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1801950", "name": "C1801950#ent", "pos": [13, 14]}}
{"token": ["C0270853#ent", "<e1>", "JME", ")", ",", "a", "form", "of", "C0391957#ent", "<e2>", "a", "strong", "genetic", "component", "provides", "informative", "pedigrees", "for", "linkage", "studies"], "h": {"id": "C0270853", "name": "C0270853#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0391957", "name": "C0391957#ent", "pos": [8, 9]}}
{"token": ["Juvenile", "myoclonic", "epilepsy", "C0270853#ent", "<e1>", ")", ",", "a", "form", "of", "C0391957#ent", "<e2>", "a", "strong", "genetic", "component", "provides", "informative", "pedigrees", "for", "linkage", "studies"], "h": {"id": "C0270853", "name": "C0270853#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0391957", "name": "C0391957#ent", "pos": [10, 11]}}
{"token": ["To", "explore", "the", "changing", "patterns", "of", "B", "cell", "subsets", "the", "expression", "of", "C1539081#ent", "<e1>", "on", "B", "cells", "the", "course", "of", "severe", "C0035222#ent", "<e2>", "SARS", ")", "and", "their", "relationship", "to", "the", "severity", "of", "the", "disease", "."], "h": {"id": "C1539081", "name": "C1539081#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [21, 22]}}
{"token": ["Colonoscopy", "and", "biopsy", "changed", "the", "radiographic", "diagnosis", "from", "ulcerative", "colitis", "C0010346#ent", "<e1>", "several", "cases", "and", "indicated", "greater", "extent", "of", "C0009373#ent", "<e2>", "several", "cases", "of", "ulcerative", "colitis", "C0010346#ent", "<e1>"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0009373", "name": "C0009373#ent", "pos": [19, 20]}}
{"token": ["Dopachrome", "tautomerase", "C1455430#ent", "<e1>", ")", "catalyzes", "the", "conversion", "of", "C1413933#ent", "<e2>", "into", "5,6-dihydroxyindole-2-carboxylic", "acid", "the", "melanogenic", "biosynthetic", "pathway"], "h": {"id": "C1455430", "name": "C1455430#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413933", "name": "C1413933#ent", "pos": [9, 10]}}
{"token": ["C1419950#ent", "<e1>", "mutations", "may", "also", "cause", "C1860166#ent", "<e2>", "AROS", ")", ",", "which", "differs", "from", "DRRS", "by", "the", "presence", "of", "structural", "eye", "anomalies", "and", "phenotypes", "similar", "to", "thalidomide", "embryopathy", "Holt-Oram", "syndrome", "(", "HOS", ")", "."], "h": {"id": "C1419950", "name": "C1419950#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1860166", "name": "C1860166#ent", "pos": [6, 7]}}
{"token": ["Sequence", "analysis", "the", "presence", "of", "an", "uptake", "C0020284#ent", "<e1>", "a", "repABC", "family", "plasmid", "replication", "module", "and", "C0079941#ent", "<e2>", "type", "IV", "secretion", "system", "TraI", "and", "TraR", "autoinducer", "proteins", "and", "several", "copper", "resistance-related", "proteins"], "h": {"id": "C0020284", "name": "C0020284#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [16, 17]}}
{"token": ["The", "sequence", "of", "a", "NAD(P)-reducing", "hydrogenase", "operon", "of", "Synechocystis", "sp.", "PCC", "6803", "genes", "for", "a", "small", "and", "a", "large", "C0020284#ent", "<e1>", "six", "additional", "C0079941#ent", "<e2>", "was", "determined", "."], "h": {"id": "C0020284", "name": "C0020284#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [23, 24]}}
{"token": ["General", "practitioners", "generally", "good", "at", "diagnosing", "conditions", "such", "as", "C0702166#ent", "<e1>", ",", "warts", ",", "rosacea", ",", "C0026393#ent", "<e2>", "vitiligo", "and", "skin", "tags"], "h": {"id": "C0702166", "name": "C0702166#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026393", "name": "C0026393#ent", "pos": [16, 17]}}
{"token": ["The", "binding", "stoichiometry", "of", "C1824513#ent", "<e1>", "to", "C1254351#ent", "<e2>", "was", "found", "to", "be", "1:1", ",", "demonstrating", "that", "oligomerization", "of", "C1824513#ent", "<e1>", "is", "not", "necessary", "for", "binding", "to", "C1254351#ent", "<e2>", "."], "h": {"id": "C1824513", "name": "C1824513#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}}
{"token": ["Certain", "C0221423#ent", "<e1>", ",", "such", "as", "hepatitis", "B", "C0155119#ent", "<e2>", "leukemia", "and", "atlantoaxial", "instability", "are", "much", "more", "common", "in", "adults", "with", "Down", "syndrome", "in", "adults", "with", "mental", "retardation", "other", "causes", "."], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0155119", "name": "C0155119#ent", "pos": [8, 9]}}
{"token": ["Quantitation", "of", "specific", "binding", "of", "ANF", "to", "C0268731#ent", "<e1>", "in", "needle", "biopsy", "specimens", "of", "three", "C4054155#ent", "<e2>", "ie", ",", "minimal-change", "disease", "membranous", "nephropathy", "and", "focal", "glomerulosclerosis", "showed", "no", "differences", "among", "the", "groups", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C4054155", "name": "C4054155#ent", "pos": [15, 16]}}
{"token": ["We", "previously", "showed", "phenotypic", "changes", "in", "podocytes", "from", "patients", "with", "diffuse", "mesangial", "sclerosis", "a", "severe", "C0268731#ent", "<e1>", "sharing", "several", "morphological", "features", "with", "C4054155#ent", "<e2>"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C4054155", "name": "C4054155#ent", "pos": [22, 23]}}
{"token": ["C4255394#ent", "<e1>", "PCSK9", ")", "is", "a", "secreted", "C0072522#ent", "<e2>", "that", "negatively", "regulates", "low", "density", "lipoprotein", "receptor", "LDLR", ")", "levels", "."], "h": {"id": "C4255394", "name": "C4255394#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}}
{"token": ["C4255394#ent", "<e1>", "PCSK9", ")", "is", "a", "secreted", "C0072522#ent", "<e2>", "that", "is", "transcriptionally", "regulated", "by", "cholesterol", "status"], "h": {"id": "C4255394", "name": "C4255394#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}}
{"token": ["The", "expression", "level", "of", "C2985165#ent", "<e1>", "cell", "injury", "induced", "by", "C3539739#ent", "<e2>", "were", "significantly", "reduced", "in", "stable", "TTE3", "cells", "overexpressing", "full-length", "chop-10", "antisense", "RNA"], "h": {"id": "C2985165", "name": "C2985165#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539739", "name": "C3539739#ent", "pos": [10, 11]}}
{"token": ["Platelets", "adhered", "to", "fibrinogen", ",", "fibronectin", ",", "C1336938#ent", "<e1>", ",", "or", "IgG", "immobilized", "on", "C0142915#ent", "<e2>", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0142915", "name": "C0142915#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", "TFIIH", "kinase", "and", "the", "C0752312#ent", "<e1>", "serine", "5", "the", "CTD", "sequence", ",", "whereas", "C1335262#ent", "<e2>", "7", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335262", "name": "C1335262#ent", "pos": [16, 17]}}
{"token": ["We", "examined", "the", "role", "of", "C1420314#ent", "<e1>", ",", "HGFA", ",", "and", "c-Met", "in", "synovial", "tissues", "C0003873#ent", "<e2>", "RA", ")", "and", "osteoarthritis", "(", "OA", ")", ",", "and", "their", "localization", "and", "mRNA", "expression", "."], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}}
{"token": ["The", "most", "significant", "elevations", "of", "OPG", "and", "C1420314#ent", "<e1>", "were", "found", "in", "patients", "with", "C0003873#ent", "<e2>", ",", "the", "rheumatic", "disease", "frequently", "associated", "with", "development", "of", "secondary", "osteoporosis"], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["We", "identified", "a", "new", "gene", ",", "HUA", "ENHANCER", "1", "C1417722#ent", "<e1>", ")", "from", "a", "sensitized", "genetic", "screen", "the", "C3539796#ent", "<e2>", "-", "1", "hua2", "-", "1", "background", "that", "is", "compromised", "in", "floral", "homeotic", "C", "function", "."], "h": {"id": "C1417722", "name": "C1417722#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539796", "name": "C3539796#ent", "pos": [18, 19]}}
{"token": ["In", "addition", "to", "the", "C0039373#ent", "<e1>", "other", "conditions", "can", "alter", "the", "distribution", "of", "the", "C0005270#ent", "<e2>", "tissues", "and", "body", "fluids"], "h": {"id": "C0039373", "name": "C0039373#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0005270", "name": "C0005270#ent", "pos": [14, 15]}}
{"token": ["C0039373#ent", "<e1>", "an", "inherited", "disorder", "which", "the", "alpha", "chain", "of", "the", "C0005270#ent", "<e2>", "bears", "the", "mutation", "."], "h": {"id": "C0039373", "name": "C0039373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005270", "name": "C0005270#ent", "pos": [11, 12]}}
{"token": ["C0039373#ent", "<e1>", "a", "lipidosis", "due", "to", "the", "deficiency", "of", "the", "C0005270#ent", "<e2>", "order", "to", "understand", "the", "molecular", "mechanisms", "this", "enzyme", "deficiency", "studied", "42", "patients", "of", "different", "ethnic", "origins", "diagnosed", "in", "Europe", "."], "h": {"id": "C0039373", "name": "C0039373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005270", "name": "C0005270#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "the", "atomic", "fluctuations", "of", "C0015505#ent", "<e1>", "complexed", "with", "C1705156#ent", "<e2>", "were", "much", "smaller", "than", "those", "of", "C0015505#ent", "<e1>", "without", "C1705156#ent", "<e2>", "."], "h": {"id": "C0015505", "name": "C0015505#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705156", "name": "C1705156#ent", "pos": [11, 12]}}
{"token": ["Clonidine", "(", "alpha", "2-adrenoceptor", "agonist", "and", "C0032912#ent", "<e1>", "(", "alpha", "1-adrenoceptor", "antagonist", "had", ",", "but", "at", "high", "doses", "some", "C0040616#ent", "<e2>"], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040616", "name": "C0040616#ent", "pos": [19, 20]}}
{"token": ["This", "low", "estimation", "of", "C0001942#ent", "<e1>", "due", "to", "an", "C1412471#ent", "<e2>", "further", "strengthened", "by", "the", "existence", "of", "only", "two", "probands", "carrying", "the", "APOB", "(", "R3500Q", ")", "mutation", "in", "the", "sample", "."], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412471", "name": "C1412471#ent", "pos": [9, 10]}}
{"token": ["Dialysate", "C3887648#ent", "<e1>", "concentration", "was", "significantly", "increased", "during", "C0235222#ent", "<e2>", "280", "+", "/-", "40", "%", "of", "control", ")", ",", "but", "was", "not", "changed", "by", "hypotensive", "hemorrhage"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0235222", "name": "C0235222#ent", "pos": [8, 9]}}
{"token": ["It", "is", "concluded", "that", "sympathetic", "nerve", "activity", "as", "defined", "from", "measurements", "of", "plasma", "C3887648#ent", "<e1>", "concentration", ",", "is", "similar", "in", "young", "patients", "with", "C0235222#ent", "<e2>", "in", "normotensive", "controls", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0235222", "name": "C0235222#ent", "pos": [23, 24]}}
{"token": ["We", "demonstrate", "a", "C0242912#ent", "<e1>", "BR", "formed", "from", "C0018969#ent", "<e2>", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018969", "name": "C0018969#ent", "pos": [8, 9]}}
{"token": ["C0003402#ent", "<e1>", "therefore", "represent", "a", "potential", "therapy", "for", "C0854416#ent", "<e2>"], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0854416", "name": "C0854416#ent", "pos": [8, 9]}}
{"token": ["Exchanging", "the", "C2917660#ent", "<e1>", "Phe", ",", "Trp", ",", "or", "C4048300#ent", "<e2>", "in", "this", "newly", "identified", "signature", "motif", "cluster", "may", "influence", "these", "peptides", "to", "interact", "with", "AR", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4048300", "name": "C4048300#ent", "pos": [9, 10]}}
{"token": ["Symptomatic", "hallmarks", "of", "C3160718#ent", "<e1>", "are", "tremor", ",", "C0233565#ent", "<e2>", ",", "rigidity", "and", "postural", "instability", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0233565", "name": "C0233565#ent", "pos": [8, 9]}}
{"token": ["Severe", "acute", "respiratory", "syndrome", "SARS", ")", "is", "a", "recently", "described", "infectious", "entity", "salient", "features", "of", "fever", ",", "headache", "and", "C0231218#ent", "<e1>", ",", "with", "rapid", "progression", "to", "C0032310#ent", "<e2>", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0032310", "name": "C0032310#ent", "pos": [26, 27]}}
{"token": ["C0025029#ent", "<e1>", "injection", "triggered", "comparable", "withdrawal", "signs", "C2987364#ent", "<e2>", "and", "in", "beta2-/-", "mice", ",", "whereas", "the", "beta4-/-", "mice", "displayed", "significantly", "milder", "somatic", "symptoms", "."], "h": {"id": "C0025029", "name": "C0025029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}}
{"token": ["In", "contrast", ",", "structural", "and", "transformational", "invariants", "specifying", "the", "C2987155#ent", "<e1>", "motion", "were", "sufficient", "to", "solve", "the", "perceptual", "C1416596#ent", "<e2>", "accurately", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [18, 19]}}
{"token": ["C2712907#ent", "<e1>", "CH", ")", "is", "an", "increasingly", "prevalent", "risk", "factor", "C0018799#ent", "<e2>", "and", "its", "treatment", "is", "troublesome", "."], "h": {"id": "C2712907", "name": "C2712907#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "show", "by", "reconstitution", "using", "purified", "proteins", "Rab27a", "and", "C1428884#ent", "<e1>", "are", "sufficient", "to", "form", "a", "transport", "complex", "C0027096#ent", "<e2>", "in", "vitro"], "h": {"id": "C1428884", "name": "C1428884#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "suggest", "that", "C1428884#ent", "<e1>", "has", "a", "role", "in", "bridging", "Rab27a", "on", "melanosomes", "and", "C0027096#ent", "<e2>", "actin", "filaments", "melanosome", "transport"], "h": {"id": "C1428884", "name": "C1428884#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [15, 16]}}
{"token": ["There", "was", "no", "evidence", "that", "the", "magnitude", "of", "the", "C1161352#ent", "<e1>", "blockade", "of", "histamine", "responsiveness", "was", "different", "before", "and", "after", "C3274161#ent", "<e2>", "(", "p", "=", "0.92", ")", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [20, 21]}}
{"token": ["C1509436#ent", "<e1>", "used", "for", "the", "treatment", "of", "C0878773#ent", "<e2>", "OAB", ")", "."], "h": {"id": "C1509436", "name": "C1509436#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0878773", "name": "C0878773#ent", "pos": [7, 8]}}
{"token": ["This", "effect", "is", "also", "observed", "in", "uninfected", "cells", "stably", "transformed", "with", "a", "plasmid", "expressing", "the", "HSV", "immediate-early", "protein", "C1413864#ent", "<e1>", "or", "in", "cells", "transfected", "with", "the", "C0079429#ent", "<e2>", "encoding", "this", "protein", "."], "h": {"id": "C1413864", "name": "C1413864#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [26, 27]}}
{"token": ["Poly(A)+", "RNA", "levels", "were", "increased", "by", "C1413864#ent", "<e1>", "in", "transfections", "with", "a", "target", "C0079429#ent", "<e2>", "having", "only", "an", "AATAAA", "recognition", "signal", "but", "no", "G/U", "box", "within", "the", "usual", "distance", "."], "h": {"id": "C1413864", "name": "C1413864#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["C0035629#ent", "<e1>", "is", "useful", "for", "the", "prevention", "and", "treatment", "of", "C0021400#ent", "<e2>", "for", "the", "treatment", "of", "Parkinson's", "disease", "drug-induced", "extrapyramidal", "disorders"], "h": {"id": "C0035629", "name": "C0035629#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [10, 11]}}
{"token": ["C1332455#ent", "<e1>", "is", "a", "component", "of", "the", "C3710678#ent", "<e2>"], "h": {"id": "C1332455", "name": "C1332455#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3710678", "name": "C3710678#ent", "pos": [7, 8]}}
{"token": ["So", "far", "the", "lesions", "of", "deletion", "are", "in", "the", "kinetochore", "localization", "domain", "the", "C1332455#ent", "<e1>", "may", "explain", "why", "the", "deletion", "lesions", "in", "the", "C3710678#ent", "<e2>", "aneuploidy", "in", "lymphoma", "and", "lymphoma", "cells"], "h": {"id": "C1332455", "name": "C1332455#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3710678", "name": "C3710678#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "investigate", "the", "function", "of", "C1332455#ent", "<e1>", "and", "Mad2", ",", "which", "are", "components", "of", "the", "C3710678#ent", "<e2>", "on", "chromosome", "segregation", "meiosis", "."], "h": {"id": "C1332455", "name": "C1332455#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3710678", "name": "C3710678#ent", "pos": [16, 17]}}
{"token": ["There", "are", "very", "few", "studies", "investigating", "the", "effects", "of", "C0699440#ent", "<e1>", "in", "normotensive", "patients", "with", "C0002962#ent", "<e2>"], "h": {"id": "C0699440", "name": "C0699440#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [15, 16]}}
{"token": ["The", "systemic", "and", "coronary", "hemodynamic", "effects", "of", "combined", "alpha-", "and", "beta-adrenergic", "blockade", "by", "C0699440#ent", "<e1>", "were", "assessed", "in", "12", "normotensive", "patients", "with", "C0002962#ent", "<e2>", "an", "ischemic", "electrocardiographic", "response", "exercise", "stress"], "h": {"id": "C0699440", "name": "C0699440#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [22, 23]}}
{"token": ["C0034678#ent", "<e1>", "is", "an", "important", "cellular", "switch", ",", "relaying", "C1335278#ent", "<e2>", "signals", "from", "the", "plasma", "membrane", "the", "nucleus", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335278", "name": "C1335278#ent", "pos": [9, 10]}}
{"token": ["The", "C1414313#ent", "<e1>", "EGFR", ")", "immunoprecipitated", "from", "fibroblasts", ",", "and", "C1704888#ent", "<e2>", "isolated", "from", "CHRF", "myeloid", "cells", "were", "associated", "with", "overlapping", "but", "quantitatively", "different", "patterns", "of", "PTPs", "."], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704888", "name": "C1704888#ent", "pos": [10, 11]}}
{"token": ["The", "development", "of", "skeletal", "muscle", "mouse", "oesophagus", "investigated", "by", "studying", "the", "expression", "of", "skeletal", "muscle", "type", "myosin", "heavy", "chain", "C0024518#ent", "<e1>", ")", ",", "troponin", "I", "TnI", ")", "and", "tropoinin", "T", "C2240312#ent", "<e2>", ")", "using", "immunocytochemical", "and", "immunoblotting", "procedures"], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2240312", "name": "C2240312#ent", "pos": [30, 31]}}
{"token": ["Although", "C0001644#ent", "<e1>", "improve", "morbidity", "and", "mortality", "in", "patients", "with", "portal", "hypertension", "associated", "with", "C0023890#ent", "<e2>", ",", "this", "has", "not", "been", "demonstrated", "in", "non-cirrhotic", "patients", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [14, 15]}}
{"token": ["A", "total", "of", "1576", "patients", "were", "diagnosed", "to", "have", "C3641106#ent", "<e1>", "PFDs", ",", "von", "Willebrand", "disease", "haemophilia", "A", "B", "and", "rare", "C0005779#ent", "<e2>", "cases", "."], "h": {"id": "C3641106", "name": "C3641106#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [21, 22]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "the", "constitutive", "glucose", "transporter", "C1335837#ent", "<e1>", ")", "in", "3T3-L1", "adipocytes", "belongs", "to", "the", "family", "of", "C1333935#ent", "<e2>", "are", "transcriptionally", "regulated", "by", "glucose", "deprivation", "."], "h": {"id": "C1335837", "name": "C1335837#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333935", "name": "C1333935#ent", "pos": [20, 21]}}
{"token": ["Data", "presented", "provide", "additional", "evidence", "that", "ret/ptc1", "is", "directly", "implicated", "in", "malignant", "transformation", "and", "demonstrate", "the", "ability", "of", "Cpd", "1", "interfere", "in", "the", "signal", "transduction", "pathway", "C0669365#ent", "<e1>", "activated", "by", "the", "C3274999#ent", "<e2>"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3274999", "name": "C3274999#ent", "pos": [31, 32]}}
{"token": ["CED", "may", "have", "formed", "a", "chance", "combination", "with", "C1853396#ent", "<e1>", "our", "patient", ",", "or", "C1418199#ent", "<e2>", "may", "be", "part", "of", "the", "CED", "phenotype", "."], "h": {"id": "C1853396", "name": "C1853396#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418199", "name": "C1418199#ent", "pos": [14, 15]}}
{"token": ["Dopa-responsive", "dystonia", "DRD", ")", "is", "an", "inherited", "metabolic", "disorder", "classified", "as", "DYT5", "with", "two", "different", "biochemical", "defects", "C2936739#ent", "<e1>", "GTP", "cyclohydrolase", "1", "GCH1", ")", "deficiency", "or", "C2673535#ent", "<e2>"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2673535", "name": "C2673535#ent", "pos": [26, 27]}}
{"token": ["The", "biological", "mechanisms", "which", "control", "the", "activity", "of", "C0014442#ent", "<e1>", "in", "these", "change", "(", "i.e.", "protein", "tyrosine-kinase", "PTKs", "]", "and", "C0666228#ent", "<e2>", "remain", "poorly", "understood", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0666228", "name": "C0666228#ent", "pos": [20, 21]}}
{"token": ["Psychrophilic", "phosphatase", "I", "from", "Shewanella", "sp.", "a", "C0014442#ent", "<e1>", "was", "found", "as", "a", "novel", "C0666228#ent", "<e2>", "(", "PTPase", ",", "EC", "3", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0666228", "name": "C0666228#ent", "pos": [14, 15]}}
{"token": ["The", "labeling", "is", "inhibited", "in", "the", "presence", "of", "C0040495#ent", "<e1>", "phenylmethane", "sulfonylfluoride", "not", "by", "C0040495#ent", "<e1>", "suggesting", "that", "a", "chymotrypsin-like", "serine", "protease", "associated", "with", "chromosomes", "."], "h": {"id": "C0040495", "name": "C0040495#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040495", "name": "C0040495#ent", "pos": [8, 9]}}
{"token": ["C0040495#ent", "<e1>", "TPCK", ")", "and", "C0040495#ent", "<e1>", "TLCK", ")", "are", "irreversible", "modifiers", "of", "histidine", "which", "is", "located", "in", "the", "catalytic", "triad", "chymotrypsin", "and", "trypsin", ",", "respectively", "."], "h": {"id": "C0040495", "name": "C0040495#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040495", "name": "C0040495#ent", "pos": [0, 1]}}
{"token": ["C0040495#ent", "<e1>", "TPCK", ")", "and", "tosyllysine", "chloromethyl", "ketone", "C0040495#ent", "<e1>", ")", "are", "irreversible", "modifiers", "of", "histidine", "which", "is", "located", "in", "the", "catalytic", "triad", "chymotrypsin", "and", "trypsin", ",", "respectively", "."], "h": {"id": "C0040495", "name": "C0040495#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040495", "name": "C0040495#ent", "pos": [0, 1]}}
{"token": ["To", "identify", "glucose-6-phosphate", "dehydrogenase", "G6PD", ")", "gene", "mutations", "23", "patients", "with", "C2939465#ent", "<e1>", "to", "gain", "further", "understanding", "of", "the", "molecular", "and", "genetic", "background", "C1333652#ent", "<e2>", "Yunnan", "province", ",", "China", "."], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [11, 12]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333652", "name": "C1333652#ent", "pos": [23, 24]}}
{"token": ["Thirty-one", "unrelated", "C2939465#ent", "<e1>", "males", "were", "analysed", "at", "DNA", "level", "the", "presence", "of", "C1333652#ent", "<e2>", "."], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [2, 3]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333652", "name": "C1333652#ent", "pos": [13, 14]}}
{"token": ["We", "report", "a", "12", "month", "double-blind", "randomized", "crossover", "trial", "of", "C0015827#ent", "<e1>", "in", "20", "children", "with", "the", "C0039082#ent", "<e2>", "of", "autism", "."], "h": {"id": "C0015827", "name": "C0015827#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [17, 18]}}
{"token": ["Adverse", "effects", "the", "transfusion", "of", "C1334043#ent", "<e1>", "tumor", "recurrence", "resistance", "to", "C0004623#ent", "<e2>", "been", "reported", "previously", ",", "but", "the", "findings", "are", "inconclusive", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [11, 12]}}
{"token": ["The", "impaired", "ability", "of", "spectrin", "dimers", "self-associate", "into", "tetramers", "is", "one", "of", "the", "most", "frequent", "defects", "associated", "with", "C0013902#ent", "<e1>", "HE", ")", "and", "its", "more", "serious", "form", ",", "hereditary", "pyropoikylocytosis", "C0520739#ent", "<e2>", ")", "."], "h": {"id": "C0013902", "name": "C0013902#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0520739", "name": "C0520739#ent", "pos": [30, 31]}}
{"token": ["The", "impaired", "ability", "of", "spectrin", "dimers", "self-associate", "into", "tetramers", "is", "one", "of", "the", "most", "frequent", "defects", "associated", "with", "C0013902#ent", "<e1>", "HE", ")", "and", "its", "more", "serious", "form", ",", "C0520739#ent", "<e2>", "HPP", ")", "."], "h": {"id": "C0013902", "name": "C0013902#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0520739", "name": "C0520739#ent", "pos": [28, 29]}}
{"token": ["Black", ",", "urban", "residents", "obtained", "C0013162#ent", "<e1>", "frequently", "and", "C0038317#ent", "<e2>", "less", "frequently", "than", "other", "groups", "."], "h": {"id": "C0013162", "name": "C0013162#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [9, 10]}}
{"token": ["Epimerase-deficiency", "galactosemia", "results", "from", "the", "impairment", "of", "UDP-galactose", "4'-epimerase", "C0751161#ent", "<e1>", ")", ",", "the", "third", "C0014442#ent", "<e2>", "in", "the", "Leloir", "pathway", "galactose", "metabolism"], "h": {"id": "C0751161", "name": "C0751161#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["A", "limited", "number", "of", "amino", "acid", "residues", "contribute", "significantly", "to", "the", "binding", "of", "C0536217#ent", "<e1>", "and", "cdk2", ",", "whereas", "a", "rather", "large", "number", "of", "C3539947#ent", "<e2>", "a", "negligible", "contribution", "."], "h": {"id": "C0536217", "name": "C0536217#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [24, 25]}}
{"token": ["Moreover", ",", "LOW", "and", "MED", "C1519228#ent", "<e1>", "did", "not", "change", "from", "one", "C1421244#ent", "<e2>", "category", "to", "another", "during", "ZMP", "."], "h": {"id": "C1519228", "name": "C1519228#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421244", "name": "C1421244#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "the", "VSV", "virion", "kinase", "low", "concentrations", "of", "melittin", ",", "the", "active", "peptide", "of", "bee", "venom", "in", "the", "presence", "of", "gamma-[32P", "]", "C1705556#ent", "<e1>", "resulted", "in", "the", "phosphorylation", "of", "C4082486#ent", "<e2>"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [30, 31]}}
{"token": ["The", "effect", "of", "the", "new", "C0012315#ent", "<e1>", "calcium", "antagonist", "C0028116#ent", "<e2>", "on", "electrophysiological", "parameters", "was", "investigated", "in", "10", "patients", "who", "were", "pretreated", "with", "a", "beta-blocker", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [5, 6]}, "relation": "chemical_structure_of", "t": {"id": "C0028116", "name": "C0028116#ent", "pos": [9, 10]}}
{"token": ["Our", "patient", "illustrates", "that", "a", "life-threatening", "C0003486#ent", "<e1>", "indeed", "occur", "as", "an", "C0032965#ent", "<e2>", "this", "minimally", "invasive", "procedure", "to", "the", "proximity", "of", "the", "aorta", "to", "the", "thoracolumbar", "vertebra"], "h": {"id": "C0003486", "name": "C0003486#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032965", "name": "C0032965#ent", "pos": [12, 13]}}
{"token": ["Thymidylate", "synthetase", "C0039667#ent", "<e1>", "ribonucleoside", "reductase", "activities", "were", "inhibited", "by", "the", "C0035064#ent", "<e2>", "in", "a", "manner", "which", "would", "contribute", "to", "the", "overall", "reduction", "of", "DNA", "synthesis", "cell", "death"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["Under", "treatment", "conditions", "to", "increase", "amplification", "of", "the", "C0039667#ent", "<e1>", "a", "number", "of", "C0035064#ent", "<e2>", "did", "increase", "SCE", "frequency", "in", "MK42", "cells", "."], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}}
{"token": ["The", "self-immolative", "prodrugs", "were", "designed", "to", "be", "activated", "by", "the", "enzyme", "carboxypeptidase", "G2", "C1424736#ent", "<e1>", ")", "releasing", "an", "C1254351#ent", "<e2>", "a", "1", ",", "6-elimination", "mechanism", "via", "an", "unstable", "intermediate", "."], "h": {"id": "C1424736", "name": "C1424736#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["In", "conclusion", ",", "C1424736#ent", "<e1>", "is", "a", "novel", "C1254351#ent", "<e2>", "with", "promising", "properties", "."], "h": {"id": "C1424736", "name": "C1424736#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}}
{"token": ["Biopsy", "specimens", "the", "oxyntic", "mucosa", "were", "obtained", "on", "210", "occasions", "from", "76", "patients", "with", "the", "C0043515#ent", "<e1>", "ZES", ")", "before", "and", "during", "C0028978#ent", "<e2>", "treatment", "."], "h": {"id": "C0043515", "name": "C0043515#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [22, 23]}}
{"token": ["Treatment", "may", "include", "prophylactic", "use", "of", "C0020592#ent", "<e1>", "or", "acute", "therapy", "the", "management", "of", "C0751495#ent", "<e2>", "."], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [14, 15]}}
{"token": ["C0242209#ent", "<e1>", "found", "preferable", "for", "the", "isolation", "of", "Staphylococci", "and", "C0085423#ent", "<e2>"], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [10, 11]}}
{"token": ["The", "surfaces", "of", "all", "microbes", "are", "'", "C0242209#ent", "<e1>", "coated", "'", "with", "molecules", "such", "as", "lipopolysaccharides", "in", "C0085423#ent", "<e2>", "capsular", "polysaccharides", "bacteria", ",", "lipoarabinomannans", "in", "mycobacteria", "and", "lipophosphoglycan", "in", "Leishmania", "."], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [17, 18]}}
{"token": ["Recent", "studies", "demonstrate", "that", "C0914069#ent", "<e1>", "also", "associated", "with", "endothelial", "dysfunction", "early", "C0004153#ent", "<e2>", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}}
{"token": ["These", "data", "identify", "C0752313#ent", "<e1>", "as", "an", "important", "intermediate", "involved", "in", "C1706223#ent", "<e2>", "phosphorylation", "and", "highlight", "the", "helical-proline-rich", "region", "a", "key", "regulatory", "domain"], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706223", "name": "C1706223#ent", "pos": [11, 12]}}
{"token": ["Disabling", ",", "chronic", ",", "persistent", "C0022573#ent", "<e1>", "is", "an", "essential", "ocular", "manifestation", "in", "autoimmune", "polyendocrinopathy-candidiasis-ectodermal", "dystrophy", "C0085859#ent", "<e2>", ")", "."], "h": {"id": "C0022573", "name": "C0022573#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0085859", "name": "C0085859#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "our", "results", "argue", "against", "a", "role", "of", "NO", "in", "the", "control", "of", "basal", "and", "C1367482#ent", "<e1>", "II-stimulated", "ACTH", "and", "C3539616#ent", "<e2>", "secretions", "."], "h": {"id": "C1367482", "name": "C1367482#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [21, 22]}}
{"token": ["Using", "CSN4", "and", "CSN5/Jab1", "mutants", ",", "we", "show", "that", "the", "CSN", "acts", "during", "Drosophila", "oogenesis", "to", "remove", "Nedd8", "from", "C4284199#ent", "<e1>", ",", "a", "subunit", "of", "the", "C1257953#ent", "<e2>"], "h": {"id": "C4284199", "name": "C4284199#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1257953", "name": "C1257953#ent", "pos": [26, 27]}}
{"token": ["For", "example", ",", "the", "symptom", "fever", "to", "the", "designation", "\"", "C0030372#ent", "<e1>", "fever", "\"", "or", "\"", "four-day", "fever", "\"", ",", "\"", "C0041471#ent", "<e2>", "."], "h": {"id": "C0030372", "name": "C0030372#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041471", "name": "C0041471#ent", "pos": [21, 22]}}
{"token": ["C0039286#ent", "<e1>", "treatment", "alone", "or", "in", "combination", "with", "C0042523#ent", "<e2>", "did", "not", "affect", "the", "activity", "of", "protein", "kinase", "C", "an", "enzyme", "implicated", "in", "the", "anti-tumor", "activity", "tamoxifen", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [8, 9]}}
{"token": ["When", "rapid", "onset", "of", "the", "analgesic", "effect", "C0020740#ent", "<e1>", "is", "required", ",", "concomitant", "ingestion", "of", "an", "C0003138#ent", "<e2>", ",", "which", "contains", "magnesium", "hydroxide", "aluminium", ",", "is", "recommended", "."], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003138", "name": "C0003138#ent", "pos": [16, 17]}}
{"token": ["To", "study", "the", "molecular", "basis", "the", "phenylalanine", "hydroxylase", "PAH", ")", "C0678941#ent", "<e1>", "Chinese", "patients", "with", "phenylketonuria", "(", "C0031485#ent", "<e2>", ")", "."], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [17, 18]}}
{"token": ["We", "report", "the", "spectrum", "of", "phenylalanine", "hydroxylase", "PAH", ")", "C0678941#ent", "<e1>", "patients", "with", "phenylketonuria", "(", "C0031485#ent", "<e2>", ")", "residing", "in", "Lithuania", "."], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [15, 16]}}
{"token": ["C0304490#ent", "<e1>", "be", "helpful", "in", "the", "prevention", "of", "these", "C3536863#ent", "<e2>", "deficiencies", "."], "h": {"id": "C0304490", "name": "C0304490#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [9, 10]}}
{"token": ["C0304490#ent", "<e1>", "usually", "prescribed", "in", "combination", "with", "other", "preparations", "to", "prevent", "C3536863#ent", "<e2>", "disturbances", "."], "h": {"id": "C0304490", "name": "C0304490#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [11, 12]}}
{"token": ["Overexpression", "of", "mutant", "superoxide", "dismutase", "1", "proteins", "associated", "with", "C1862939#ent", "<e1>", "decreased", "proteasomal", "activities", "in", "the", "absence", "of", "C3538705#ent", "<e2>", "and", "accelerated", "the", "apoptosis", "induced", "by", "C3538705#ent", "<e2>", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538705", "name": "C3538705#ent", "pos": [18, 19]}}
{"token": ["Combining", "SDS-PAGE", "with", "mass", "spectrometry", "a", "novel", "C1422036#ent", "<e1>", "WSSV", "was", "identified", "to", "match", "an", "C0079941#ent", "<e2>", "ORF", ")", "of", "WSSV", "genome", "."], "h": {"id": "C1422036", "name": "C1422036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}}
{"token": ["The", "human", "endogenous", "retrovirus", "type", "W", "C1422036#ent", "<e1>", ")", "family", "includes", "proviruses", "with", "intact", "C0079941#ent", "<e2>", "appear", "to", "be", "under", "selection", "pressure", "suggesting", "that", "some", "C1422036#ent", "<e1>", "proviruses", "may", "remain", "active", "in", "higher", "primates", "."], "h": {"id": "C1422036", "name": "C1422036#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [14, 15]}}
{"token": ["Here", "the", "expression", "of", "C1968833#ent", "<e1>", "and", "synthesis", "of", "NO", "was", "studied", "in", "C0014038#ent", "<e2>", "cattle", ",", "sheep", ",", "and", "goats", "."], "h": {"id": "C1968833", "name": "C1968833#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [13, 14]}}
{"token": ["GNA", ",", "the", "mannose-specific", "lectin", "Galanthus", "nivalis", "confirmed", "to", "bind", "C3813120#ent", "<e1>", "(", "C1412046#ent", "<e2>", "but", "another", "protein", "was", "copurified", "with", "C1412046#ent", "<e2>", "total", "human", "plasma", "."], "h": {"id": "C3813120", "name": "C3813120#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412046", "name": "C1412046#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "mutations", "in", "the", "C1706675#ent", "<e1>", "been", "shown", "to", "cause", "several", "different", "C0042075#ent", "<e2>"], "h": {"id": "C1706675", "name": "C1706675#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [13, 14]}}
{"token": ["C0960580#ent", "<e1>", "is", "important", "in", "the", "biotransformation", "of", "C0012010#ent", "<e2>", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [8, 9]}}
{"token": ["C0024730#ent", "<e1>", ",", "hydrocortisone", "and", "C2757070#ent", "<e2>", "were", "selected", "as", "model", "penetrants", "to", "assess", "the", "mode", "of", "action", "of", "eight", "potential", "penetration", "enhancers", "in", "human", "skin", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [5, 6]}}
{"token": ["The", "results", "suggest", "that", "C0024730#ent", "<e1>", "penetrated", "via", "a", "polar", "route", "hydrocortisone", "by", "a", "mainly", "lipid", "route", "C2757070#ent", "<e2>", "via", "a", "lipid", "pathway", "its", "penetration", "rate", "was", "probably", "affected", "by", "aqueous", "layers", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [17, 18]}}
{"token": ["Surfactant", "is", "a", "safe", "C1875319#ent", "<e1>", "appears", "promising", "for", "the", "prevention", "and", "treatment", "of", "neonatal", "C1826711#ent", "<e2>", ",", "although", "additional", "clinical", "trials", "long-term", "follow-up", "are", "needed", "to", "determine", "its", "true", "efficacy", "."], "h": {"id": "C1875319", "name": "C1875319#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826711", "name": "C1826711#ent", "pos": [15, 16]}}
{"token": ["A", "46-year-old", "woman", "had", "been", "suffering", "from", "recurrent", "C0014493#ent", "<e1>", "vascularized", "corneal", "scars", "and", "incipient", "pannus", "C1336952#ent", "<e2>", "for", "five", "years", "."], "h": {"id": "C0014493", "name": "C0014493#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1336952", "name": "C1336952#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "use", "of", "a", "yeast", "two-hybrid", "system", "to", "the", "identification", "two", "C3540564#ent", "<e1>", "PAK4", "that", "associate", "with", "the", "C0083132#ent", "<e2>", "are", "important", "for", "the", "protective", "functions", "KGF", "."], "h": {"id": "C3540564", "name": "C3540564#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0083132", "name": "C0083132#ent", "pos": [20, 21]}}
{"token": ["This", "evaluation", "supports", "the", "results", "of", "BOOY3", "demonstrating", "the", "superiority", "of", "the", "C0717309#ent", "<e1>", "combination", "to", "C0000970#ent", "<e2>", "alone", "or", "aspirin", "."], "h": {"id": "C0717309", "name": "C0717309#ent", "pos": [12, 13]}, "relation": "has_constitutional_part", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [16, 17]}}
{"token": ["After", "establishing", "a", "diagnosis", "of", "C0020502#ent", "<e1>", "in", "patients", "with", "C1832615#ent", "<e2>", "and", "tHPT", "a", "parathyroidectomy", "(", "PTX", ")", "frequently", "becomes", "necessary", "to", "decrease", "the", "mass", "of", "the", "hyperplastic", "parathyroid", "tissue"], "h": {"id": "C0020502", "name": "C0020502#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C1832615", "name": "C1832615#ent", "pos": [10, 11]}}
{"token": ["C0014442#ent", "<e1>", "structure-activity", "relationship", "data", "regarding", "the", "inhibitor", "C0219891#ent", "<e2>", "are", "described", "along", "with", "results", "from", "in", "vivo", "antifungal", "assays"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0219891", "name": "C0219891#ent", "pos": [8, 9]}}
{"token": ["These", "included", "seizures", ",", "absence", "seizures", ",", "metachromatic", "leukodystrophy", "Schilder's", "disease", "C0007789#ent", "<e1>", "hemiparkinsonism", ",", "Wilson's", "disease", "vasculitis", ",", "spinocerebellar", "ataxia", "C0085084#ent", "<e2>", "nutritional", "amblyopia", "tapetoretinal", "degeneration", "catatonic", "schizophrenia", "and", "malingering", ",", "among", "others", "."], "h": {"id": "C0007789", "name": "C0007789#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [21, 22]}}
{"token": ["Oral", "administration", "C1321596#ent", "<e1>", "to", "patients", "with", "type", "1", "Gaucher", "disease", "attenuates", "the", "synthesis", "of", "C0017205#ent", "<e2>", ",", "the", "substrate", "of", "the", "deficient", "glucocerebrosidase", "."], "h": {"id": "C1321596", "name": "C1321596#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0017205", "name": "C0017205#ent", "pos": [15, 16]}}
{"token": ["This", "has", "stimulated", "various", "investigators", "to", "attempt", "nonsurgical", "methods", "treatment", "such", "as", "systemic", "administration", "methotrexate", "or", "C0701303#ent", "<e1>", "mifepristone", ")", "or", "local", "injection", "methotrexate", ",", "potassium", "chloride", "or", "C3540754#ent", "<e2>", "under", "laparoscopic", "or", "ultrasonographic", "guidance", "."], "h": {"id": "C0701303", "name": "C0701303#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [28, 29]}}
{"token": ["Protein", "binding", "displacement", "appears", "to", "be", "the", "basis", "of", "C0036079#ent", "<e1>", "interactions", "with", "diclofenac", ",", "flurbiprofen", ",", "ibuprofen", ",", "C0064104#ent", "<e2>", ",", "ketoprofen", ",", "naproxen", ",", "phenytoin", "and", "tolmetin", "."], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0064104", "name": "C0064104#ent", "pos": [19, 20]}}
{"token": ["The", "role", "of", "topoisomerase", "IV", "C0146224#ent", "<e1>", "and", "of", "the", "structural", "maintenance", "chromosomes", "(", "C1539322#ent", "<e2>", ")", "complex", "in", "chromosome", "compaction", "in", "global", "protein", "synthesis", "investigated", "."], "h": {"id": "C0146224", "name": "C0146224#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [14, 15]}}
{"token": ["C0886927#ent", "<e1>", "has", "a", "significantly", "effective", "action", "on", "tremor", "and", "C0231528#ent", "<e2>", "moderate", "cases", "of", "alcoholism", ".--"], "h": {"id": "C0886927", "name": "C0886927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [10, 11]}}
{"token": ["The", "thesis", "fails", "to", "explain", "its", "topography", ",", "site", "specific", "severity", "and", "the", "iatrogenic", "and", "experimental", "hemodynamic", "induction", "of", "C0003850#ent", "<e1>", "under", "conditions", "complying", "with", "the", "logic", "of", "C0041296#ent", "<e2>", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [28, 29]}}
{"token": ["These", "studies", "show", "that", "infection", "is", "not", "necessary", "for", "murine", "C0003850#ent", "<e1>", "and", "that", ",", "unlike", "peptic", "ulcer", "C0041296#ent", "<e2>", "can", "not", "be", "fulfilled", "for", "any", "infectious", "agent", "C0003850#ent", "<e1>", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [18, 19]}}
{"token": ["Aorto-enteric", "fistula", "is", "usually", "caused", "by", "C0003850#ent", "<e1>", ",", "but", "may", "also", "be", "due", "to", "syphilis", "or", "C0041296#ent", "<e2>", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [17, 18]}}
{"token": ["The", "causes", "of", "development", "of", "pathological", "changes", "in", "the", "aortic", "wall", "as", "follows", ";", "C0003850#ent", "<e1>", "-", "in", "3", "patients", ",", "C0041296#ent", "<e2>", "-", "in", "1", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [21, 22]}}
{"token": ["C0935929#ent", "<e1>", "rosiglitazone", "and", "pioglitazone", ")", "reduce", "C1826658#ent", "<e2>", "levels", ",", "while", "insulin", "is", "ineffective", "."], "h": {"id": "C0935929", "name": "C0935929#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826658", "name": "C1826658#ent", "pos": [7, 8]}}
{"token": ["By", "complementary", "DNA", "cloning", "have", "identified", "two", "amino", "acid", "substitutions", "in", "the", "intracellular", "region", "the", "human", "GH", "receptor", "a", "child", "with", "C0878787#ent", "<e1>", "clinical", "features", "of", "the", "C0271568#ent", "<e2>"], "h": {"id": "C0878787", "name": "C0878787#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0271568", "name": "C0271568#ent", "pos": [27, 28]}}
{"token": ["Supraventricular", "tachyarrhythmias", "seen", "in", "11", "patients", ",", "C0033036#ent", "<e1>", "42", "patients", ";", "49", "patients", "did", "not", "have", "C1825840#ent", "<e2>", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [17, 18]}}
{"token": ["Recovery", "C1419337#ent", "<e1>", "after", "one", "C0032285#ent", "<e2>", "correlated", "with", "the", "extravasation", "of", "Evans", "Blue", "dye", "the", "tissue", "at", "all", "airway", "levels", ",", "indicating", "that", "airway", "edema", "have", "contributed", "to", "airway", "narrowing"], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [5, 6]}}
{"token": ["After", "secondary", "OVA", "challenge", ",", "C1419337#ent", "<e1>", "significantly", "increased", "as", "did", "the", "number", "of", "C0032285#ent", "<e2>", "IL-4", "and", "IL-5", "production", "in", "bronchoalveolar", "lavage", "fluid", "BALF", ")", "."], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "show", "that", "under", "baseline", "conditions", ",", "Vti", "accounted", "for", "a", "major", "proportion", "of", "C1419337#ent", "<e1>", ";", "during", "both", "passive", "C0032285#ent", "<e2>", "MCh", "challenge", "this", "proportion", "increased", "progressively", "."], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [21, 22]}}
{"token": ["3'-deoxy-3'-[18F]fluorothymidine", "uptake", "is", "dependent", "on", "C1420747#ent", "<e1>", "TK", ")", "activity", ",", "but", "the", "effects", "of", "C0729502#ent", "<e2>", "unknown", "."], "h": {"id": "C1420747", "name": "C1420747#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [15, 16]}}
{"token": ["Leukotrienes", "A4", "D4", ",", "and", "C3272385#ent", "<e1>", "were", "much", "weaker", "inhibitors", "of", "the", "purified", "C0014442#ent", "<e2>", "(", "by", "at", "least", "3", "orders", "of", "magnitude", ")", "."], "h": {"id": "C3272385", "name": "C3272385#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["Previous", "injection", "of", "C0016186#ent", "<e1>", "(", "100", "ng", ")", "into", "the", "C0000294#ent", "<e2>", "blocked", "the", "increases", "in", "Na+", "and", "K+", "excretion", ",", "water", "intake", "blood", "pressure", "induced", "by", "carbachol", "."], "h": {"id": "C0016186", "name": "C0016186#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000294", "name": "C0000294#ent", "pos": [11, 12]}}
{"token": ["Cd", "content", "in", "blood", "was", "reduced", "significantly", "by", "C0008286#ent", "<e1>", "or", "the", "combination", "of", "C0008286#ent", "<e1>", "and", "C0028094#ent", "<e1>", ",", "but", "elevated", "by", "C0028094#ent", "<e1>", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [17, 18]}}
{"token": ["The", "results", "indicated", "that", "these", "inhibitors", "could", "protect", "mice", "against", "the", "toxic", "effects", "Cd", "in", "liver", "and", "kidney", "tissues", "while", "C0008286#ent", "<e1>", "was", "more", "efficient", "than", "C0028094#ent", "<e2>", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [26, 27]}}
{"token": ["Here", "we", "examined", "the", "C1539479#ent", "<e1>", "of", "PEN-2", "in", "the", "absence", "of", "PS", "expression", "or", "C0379528#ent", "<e2>"], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0379528", "name": "C0379528#ent", "pos": [15, 16]}}
{"token": ["Dexamethasone", "markedly", "suppressed", "the", "excretion", "of", "both", "kallikrein", "and", "C0014894#ent", "<e1>", "increased", "the", "excretion", "of", "C0086376#ent", "<e2>", "(", "inhibitors", ")", "that", "bind", "to", "each", "of", "these", "enzymes", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["Immune", "complexes", "precipitated", "with", "C0032483#ent", "<e1>", "PEG", ")", "from", "sera", "of", "patients", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", ",", "psoriatic", "arthritis", "systemic", "lupus", "erythematosus"], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}}
{"token": ["The", "C-terminal", "serine", "518", "phosphorylated", "both", "by", "C1955933#ent", "<e1>", "PAKs", ")", "and", "C0010531#ent", "<e2>", "PKA", ")", "."], "h": {"id": "C1955933", "name": "C1955933#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}}
{"token": ["C1414668#ent", "<e1>", "regulates", "the", "expression", "of", "C1333572#ent", "<e2>", "and", "binds", "to", "a", "conserved", "element", "in", "the", "C1333572#ent", "<e2>", "promoter", "in", "vivo"], "h": {"id": "C1414668", "name": "C1414668#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333572", "name": "C1333572#ent", "pos": [6, 7]}}
{"token": ["Plants", "overexpressing", "C1424815#ent", "<e1>", "showed", "enhanced", "resistance", "to", "an", "MT", "C0013227#ent", "<e2>", "and", "increased", "hypocotyl", "elongation"], "h": {"id": "C1424815", "name": "C1424815#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["When", "confluent", "HeLa", "cell", "C0872351#ent", "<e1>", "were", "wounded", ",", "C0529196#ent", "<e2>", "and", "alpha(5)beta(1", ")", "redistributed", "to", "the", "leading", "edge", "and", "co-localized", ",", "which", "is", "suggestive", "of", "a", "cis", "orientation"], "h": {"id": "C0872351", "name": "C0872351#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0529196", "name": "C0529196#ent", "pos": [9, 10]}}
{"token": ["Pretreatment", "with", "the", "C0022614#ent", "<e1>", "antagonists", ",", "MK-801", "and", "LY235959", ",", "but", "not", "the", "C3536879#ent", "<e2>", "naloxone", ",", "blocked", "the", "induction", "of", "allodynia", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536879", "name": "C3536879#ent", "pos": [14, 15]}}
{"token": ["Samples", "were", "tested", "for", "the", "presence", "of", "FMDV", ",", "C0042720#ent", "<e1>", "specific", "IgA", "antibodies", "antibodies", "against", "FMDV", "non-structural", "(", "NS", ")", "C0086376#ent", "<e2>", "or", "neutralising", "antibodies"], "h": {"id": "C0042720", "name": "C0042720#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}}
{"token": ["Unstimulated", "C1419846#ent", "<e1>", "neutrophils", "expressed", "approximately", "30,000", "active", "C3889161#ent", "<e2>", "per", "cell", ",", "while", "controls", "expressed", "approximately", "6,000", "."], "h": {"id": "C1419846", "name": "C1419846#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889161", "name": "C3889161#ent", "pos": [8, 9]}}
{"token": ["The", "transformed", "kidney", "proximal", "tubule", "cell", "line", "C0724624#ent", "<e1>", ",", "maintains", "high", "C0907533#ent", "<e2>", "levels", "of", "the", "first", "polyamine", "biosynthetic", "enzyme", ",", "ornithine", "decarboxylase", "ODC", ")", "."], "h": {"id": "C0724624", "name": "C0724624#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [12, 13]}}
{"token": ["No", "patient", "was", "excluded", "from", "initial", "C1537501#ent", "<e1>", "amputation", "unless", "C0017086#ent", "<e2>", "at", "that", "level", "or", "severe", "joint", "contracture", "present", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017086", "name": "C0017086#ent", "pos": [10, 11]}}
{"token": ["Incubation", "of", "the", "cells", "with", "C4282444#ent", "<e1>", "not", "only", "increased", "p75", "and", "C0124604#ent", "<e2>", "gene", "expression", "p75-", "cells", ",", "but", "also", "augmented", "the", "expression", "of", "these", "genes", "in", "p75", "+", "cells", "."], "h": {"id": "C4282444", "name": "C4282444#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [12, 13]}}
{"token": ["mRNA", "levels", "of", "C1417533#ent", "<e1>", "MRF", ")", "myogenin", ",", "alpha-actin", ",", "thermoregulatory", "uncoupling", "protein", "C0536847#ent", "<e2>", "and", "glucose", "transporter", "isotype", "glut4", "increased", "rapidly", "during", "early", "stage", "differentiation", "."], "h": {"id": "C1417533", "name": "C1417533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0536847", "name": "C0536847#ent", "pos": [14, 15]}}
{"token": ["Bortezomib-induced", "apoptosis", "was", "associated", "with", "activation", "of", "caspase", "3", "cleavage", "of", "C1709384#ent", "<e1>", "and", "induction", "of", "C0598388#ent", "<e2>", "and", "p21", "expression", "."], "h": {"id": "C1709384", "name": "C1709384#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0598388", "name": "C0598388#ent", "pos": [16, 17]}}
{"token": ["Recent", "reports", "established", "an", "association", "of", "C0035258#ent", "<e1>", "RLS", ")", "and", "spinocerebellar", "ataxia", "C0018790#ent", "<e2>", ")", "type", "1", ",", "2", ",", "and", "3", "."], "h": {"id": "C0035258", "name": "C0035258#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018790", "name": "C0018790#ent", "pos": [13, 14]}}
{"token": ["Age", "at", "C0035258#ent", "<e1>", "onset", "in", "C0018790#ent", "<e2>", "was", "49.0", "+", "/-", "10.9", "years", "."], "h": {"id": "C0035258", "name": "C0035258#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018790", "name": "C0018790#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "C1571622#ent", "<e1>", "siRNA", "blunted", "thrombin-mediated", "increases", "in", "C0001477#ent", "<e2>", ",", "polymerized", "actin", "formation", "and", "myosin", "light", "chain", "phosphorylation", "events", "critical", "to", "the", "thrombin-mediated", "permeability", "response", "."], "h": {"id": "C1571622", "name": "C1571622#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [9, 10]}}
{"token": ["Altered", "PBPs", "are", "encoded", "by", "mosaic", "genes", "have", "emerged", "by", "recombinational", "events", "the", "C2698695#ent", "<e1>", "pneumococci", "and", "their", "C4277608#ent", "<e2>", "in", "closely", "related", "streptococcal", "species"], "h": {"id": "C2698695", "name": "C2698695#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [18, 19]}}
{"token": ["Because", "pituitary", "function", "tests", "that", "ACTH", ",", "PRL", ",", "C3539616#ent", "<e1>", "and", "TSH", "were", "of", "low", "levels", "hydrocortisone", "and", "C1881373#ent", "<e2>", "were", "orally", "administered", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1881373", "name": "C1881373#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "show", "that", "these", "two", "C0031727#ent", "<e1>", "phosphorylate", "the", "same", "SR", "proteins", "in", "vitro", "but", "that", "C0255758#ent", "<e2>", "has", "the", "higher", "specific", "activity", "toward", "ASF/SF2", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0255758", "name": "C0255758#ent", "pos": [18, 19]}}
{"token": ["At", "concentrations", "of", "C0013227#ent", "<e1>", "the", "critical", "concentration", "required", "for", "C0139905#ent", "<e2>", "activation", ",", "p53", "and", "p21(WAF-1", ")", "were", "induced", "independently", "of", "C0139905#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [10, 11]}}
{"token": ["C0031656#ent", "<e1>", "PGK", ")", "is", "one", "of", "the", "key", "C3541394#ent", "<e2>", "of", "this", "pathway", "as", "it", "generates", "ATP", "."], "h": {"id": "C0031656", "name": "C0031656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}}
{"token": ["C0031656#ent", "<e1>", "one", "of", "several", "C3541394#ent", "<e2>", "in", "which", "age-related", "effects", "have", "been", "identified", "."], "h": {"id": "C0031656", "name": "C0031656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}}
{"token": ["In", "Japan", ",", "there", "have", "been", "only", "9", "reported", "cases", "of", "lymphoproliferative", "disorders", "including", "five", "C1707163#ent", "<e1>", "patients", ")", "accompanied", "with", "C0311386#ent", "<e2>"], "h": {"id": "C1707163", "name": "C1707163#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0311386", "name": "C0311386#ent", "pos": [21, 22]}}
{"token": ["While", "the", "incidental", "discovery", "of", "renal", "cell", "carcinoma", "a", "C0041328#ent", "<e1>", "a", "classical", "finding", ",", "the", "discovery", "of", "C0041296#ent", "<e2>", "lesions", "after", "nephrectomy", "for", "cancer", "is", "exceptional", "."], "h": {"id": "C0041328", "name": "C0041328#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [18, 19]}}
{"token": ["C3280214#ent", "<e1>", "an", "autosomal", "recessive", "syndrome", "of", "congenital", "microcephaly", "cortical", "dysplasia", "microcornea", ",", "cataracts", ",", "C0029124#ent", "<e2>", "severe", "mental", "retardation", "hypotonic", "diplegia", ",", "and", "hypogenitalism", "."], "h": {"id": "C3280214", "name": "C3280214#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [15, 16]}}
{"token": ["A", "delayed", "chylomicron", "(", "CM", ")", "clearance", "rate", "a", "known", "risk", "factor", "C0004153#ent", "<e1>", ",", "has", "been", "described", "in", "adults", "with", "diabetes", "type", "1", "C1415941#ent", "<e2>", ")", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415941", "name": "C1415941#ent", "pos": [24, 25]}}
{"token": ["Low-dose", "C0034414#ent", "<e1>", "has", "a", "potential", "as", "an", "adjunctive", "therapy", "patients", "of", "the", "C2673193#ent", "<e2>", "frequent", "implantable", "cardioverter", "defibrillator", "discharges", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2673193", "name": "C2673193#ent", "pos": [13, 14]}}
{"token": ["C0034414#ent", "<e1>", "has", "been", "proved", "efficient", "in", "cases", "of", "C2673193#ent", "<e2>"], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2673193", "name": "C2673193#ent", "pos": [9, 10]}}
{"token": ["As", "shown", "in", "RNase", "protection", "assays", "C0251991#ent", "<e1>", "also", "inhibited", "insulin", "stimulation", "the", "endogenous", "C0015923#ent", "<e2>", "mRNA", "levels", "in", "3T3-L1", "adipocytes", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015923", "name": "C0015923#ent", "pos": [14, 15]}}
{"token": ["The", "activity", "of", "LIMK2", ",", "distinct", "from", "C1334342#ent", "<e1>", ",", "toward", "cofilin", "phosphorylation", "did", "not", "change", "in", "the", "C0080054#ent", "<e2>"], "h": {"id": "C1334342", "name": "C1334342#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [18, 19]}}
{"token": ["Hormone", "action", "rapidly", "terminated", "by", "the", "N-terminal", "cleavage", "C0061355#ent", "<e1>", "at", "Ala2", "by", "the", "C0002570#ent", "<e2>", ",", "dipeptidyl", "peptidase", "IV", "DPPIV", ")", "."], "h": {"id": "C0061355", "name": "C0061355#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002570", "name": "C0002570#ent", "pos": [14, 15]}}
{"token": ["Signal", "transducer", "activator", "of", "transcription", "3", "STAT3", ")", "and", "nuclear", "factor", "kappaB", "NF-kappaB", ")", "are", "important", "transcription", "factors", "in", "C0156221#ent", "<e1>", "and", "other", "inflammatory", "processes", "including", "transcription", "of", "the", "C0669372#ent", "<e2>", "iNOS", ")", "gene", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [29, 30]}}
{"token": ["Measurement", "of", "C0669372#ent", "<e1>", "and", "arginase", "activities", "in", "macrophages", "isolated", "from", "C0156221#ent", "<e2>", "that", "these", "cells", "were", "a", "major", "source", "of", "glomerular", "C0669372#ent", "<e1>", "but", "not", "arginase", "activity", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [2, 3]}}
{"token": ["Noxa", "interacts", "with", "the", "antiapoptotic", "protein", "C1366587#ent", "<e1>", "and", "promotes", "C1332379#ent", "<e2>", "release", "from", "C1366587#ent", "<e1>", ",", "suggesting", "that", "up-regulation", "of", "Noxa", "might", "counteract", "C1366587#ent", "<e1>", "accumulation", "after", "bortezomib", "treatment", "."], "h": {"id": "C1332379", "name": "C1332379#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366587", "name": "C1366587#ent", "pos": [6, 7]}}
{"token": ["Following", "serum", "withdrawal", ",", "C1332379#ent", "<e1>", "accumulation", "becomes", "independent", "of", "C1366587#ent", "<e2>", "level", "and", "cells", "are", "sensitized", "to", "pro-apoptotic", "stimuli", "."], "h": {"id": "C1332379", "name": "C1332379#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366587", "name": "C1366587#ent", "pos": [10, 11]}}
{"token": ["C1565427#ent", "<e1>", ",", "the", "autonomously", "expressed", "carboxyl-terminal", "region", "C1366894#ent", "<e2>", "FAK", ")", ",", "is", "expressed", "in", "tissues", "that", "are", "rich", "in", "vascular", "smooth", "muscle", "cells", "VSMCs", ")", "."], "h": {"id": "C1565427", "name": "C1565427#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366894", "name": "C1366894#ent", "pos": [8, 9]}}
{"token": ["Focal", "adhesion", "kinase", "pp125FAK", "or", "C1565427#ent", "<e1>", ")", "is", "a", "C1366894#ent", "<e2>", "stimulated", "in", "response", "to", "cell", "interactions", "extracellular", "matrix", "components", "and", "by", "exposure", "to", "variety", "of", "agonists", ",", "including", "neuropeptides", "."], "h": {"id": "C1565427", "name": "C1565427#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366894", "name": "C1366894#ent", "pos": [10, 11]}}
{"token": ["The", "chronic", "inflammatory", "bowel", "diseases", "C0010346#ent", "<e1>", "ulcerative", "colitis", "common", "causes", "of", "C0017178#ent", "<e2>", "northern", "Europe", "affecting", "as", "many", "as", "one", "in", "250", "people", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [12, 13]}}
{"token": ["Relative", "activity", "each", "C0752243#ent", "<e1>", "BPN", "'", "to", "C2987364#ent", "<e2>", "enzyme", "was", "estimated", "by", "monitoring", "the", "increased", "value", "of", "absorbance", "caused", "by", "enzymatic", "hydrolysis", "of", "a", "chromogenic", "substrate", "."], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}}
{"token": ["A", "high-activity", "C0752243#ent", "<e1>", "Ile31Leu", "replacement", "(", "I31L", ")", "as", "well", "as", "the", "C2987364#ent", "<e2>", "enzyme", "show", "poor", "recognition", "acid", "residues", "the", "P1", "substrate"], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}}
{"token": ["Proteolysis", "in", "vitro", "trypsin", "or", "C0752243#ent", "<e1>", "of", "isolated", "cytoplasmic", "C2987364#ent", "<e2>", "and", "mutant", "leucyl-tRNA", "synthetases", "however", ",", "did", "not", "establish", "and", "difference", "in", "the", "degradation", "products", "and", "in", "their", "catalytic", "properties", "."], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}}
{"token": ["When", "the", "aspartic", "acid", "residue", "the", "active", "site", "Asp32", ")", "was", "altered", "to", "asparagine", ",", "processing", "of", "mutant", "C0752243#ent", "<e1>", "was", "not", "observed", "even", "in", "the", "presence", "of", "C2987364#ent", "<e2>", "pro-subtilisin", "."], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [28, 29]}}
{"token": ["We", "recommend", "a", "trial", "of", "C0304497#ent", "<e1>", "progressive", "ocular", "inflammatory", "diseases", "to", "other", "medications", "before", "there", "is", "irreversible", "C3665346#ent", "<e2>"], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3665346", "name": "C3665346#ent", "pos": [18, 19]}}
{"token": ["We", "also", "report", "that", "C1421224#ent", "<e1>", "possesses", "C0062773#ent", "<e2>", "activity", "and", "suggest", "an", "evolutionary", "relationship", "C1421224#ent", "<e1>", "and", "other", "GNAT", "members", "."], "h": {"id": "C0062773", "name": "C0062773#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421224", "name": "C1421224#ent", "pos": [4, 5]}}
{"token": ["Cells", "treated", "with", "C0033417#ent", "<e1>", ",", "washed", "and", "then", "cultured", "with", "antibody", ",", "exhibited", "a", "greater", "than", "5-fold", "enhancement", "of", "DNA", "synthesis", "C0033417#ent", "<e1>", "treatment", ",", "per", "se", ",", "was", "not", "C0026249#ent", "<e1>", "."], "h": {"id": "C0033417", "name": "C0033417#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [31, 32]}}
{"token": ["Two", "of", "three", "C1412501#ent", "<e1>", "cases", "with", "cotton-wool-like", "spots", "developed", "Pneumocystis", "carinii", "C0032285#ent", "<e2>", "a", "few", "weeks", "after", "ophthalmoscopic", "examination"], "h": {"id": "C1412501", "name": "C1412501#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}}
{"token": ["We", "have", "previously", "reported", "that", "the", "gene", "responsible", "for", "the", "C3539821#ent", "<e1>", "mouse", "is", "an", "C0002085#ent", "<e2>", "of", "the", "piebald", "mutations", "of", "the", "endothelin", "B", "receptor", "gene", "Ednrb", ")", "."], "h": {"id": "C3539821", "name": "C3539821#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [15, 16]}}
{"token": ["Four", "patients", "(", "2", "were", "HBsAg", "positive", ")", "with", "C0267797#ent", "<e1>", "VH", ")", "developed", "acute", "renal", "failure", "C0525037#ent", "<e2>", ")", "in", "the", "course", "of", "their", "illness", "and", "in", "the", "absence", "of", "other", "complications", "."], "h": {"id": "C0267797", "name": "C0267797#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [17, 18]}}
{"token": ["C0066411#ent", "<e1>", "also", "inhibited", "the", "R5", "strain", "(", "C1412179#ent", "<e2>", ")", "envelope-pseudotyped", "HIV", "replication", "induced", "by", "morphine", "."], "h": {"id": "C0066411", "name": "C0066411#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [8, 9]}}
{"token": ["Adjusted", "C1963718#ent", "<e1>", "relating", "mode", "of", "delivery", "and", "each", "of", "the", "outcomes", "(", "fever", "without", "infection", ",", "urinary", "tract", "infection", "C0014179#ent", "<e2>", ",", "and", "any", "postpartum", "morbidity", "were", "similar", "to", "unadjusted", "C1963718#ent", "<e1>", "."], "h": {"id": "C0014179", "name": "C0014179#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1963718", "name": "C1963718#ent", "pos": [1, 2]}}
{"token": ["A", "case", "of", "oral", "involvement", "of", "amyloid", "associated", "(", ")", "C0002726#ent", "<e1>", "(", "secondary", "systemic", "amyloidosis", "in", "a", "patient", "who", "is", "suffering", "from", "C0003872#ent", "<e2>", "ankylosing", "spondylitis", "is", "described", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [23, 24]}}
{"token": ["A", "case", "is", "presented", "of", "the", "C0751837#ent", "<e1>", "variety", "of", "C0022336#ent", "<e2>", "particular", "reference", "to", "the", "cerebellar", "cortex"], "h": {"id": "C0751837", "name": "C0751837#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [10, 11]}}
{"token": ["A", "pathological", "system", "severe", "and", "progressive", "loss", "of", "granule", "cells", "studied", ":", "the", "C0751837#ent", "<e1>", "form", "of", "C0022336#ent", "<e2>", "where", "the", "tissue", "geometry", "is", "minimally", "disturbed"], "h": {"id": "C0751837", "name": "C0751837#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [17, 18]}}
{"token": ["One", "protein", "was", "identified", "as", "the", "C-terminal", "extremity", "C1416790#ent", "<e1>", "called", "the", "C0078939#ent", "<e2>", "."], "h": {"id": "C1416790", "name": "C1416790#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [12, 13]}}
{"token": ["Additional", "evaluations", "were", "performed", "on", "13", "marketed", "compounds", "by", "conducting", "inhibition", "studies", "in", "Caco-2", "cells", "classical", "P-gp", "inhibitors", "ketoconazole", ",", "C0010592#ent", "<e1>", ",", "verapamil", ",", "quinidine", ",", "C0286738#ent", "<e2>", "etc", ".", ")"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0286738", "name": "C0286738#ent", "pos": [27, 28]}}
{"token": ["It", "is", "also", "clear", "that", "some", "of", "the", "substrates", "for", "CYP3A4", "(", "e.g.", ",", "C0010592#ent", "<e1>", ",", "midazolam", ",", "nifedipine", ",", "verapamil", "and", "C0286738#ent", "<e2>", ")", "undergo", "significant", "metabolic", "extraction", "the", "gut", "wall"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0286738", "name": "C0286738#ent", "pos": [23, 24]}}
{"token": ["Selective", "inhibitors", "of", "C4082365#ent", "<e1>", "C0007259#ent", "<e2>", "used", "in", "the", "evaluation", "of", "C4082365#ent", "<e1>", "C0007259#ent", "<e2>", "activities", "in", "the", "rat", "retina", "."], "h": {"id": "C0007259", "name": "C0007259#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4082365", "name": "C4082365#ent", "pos": [3, 4]}}
{"token": ["Myelokathexis", "is", "a", "rare", "from", "of", "C0023530#ent", "<e1>", "that", "is", "probably", "congenital", ",", "characterized", "by", "severe", "C0221023#ent", "<e2>", "recurrent", "infections", "granulocytic", "hyperplasia", "the", "bone", "marrow", "and", "degenerative", "changes", "in", "mature", "neutrophils", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221023", "name": "C0221023#ent", "pos": [16, 17]}}
{"token": ["For", "patients", "with", "C0023530#ent", "<e1>", "resulting", "from", "cytotoxic", "chemotherapy", "bone", "marrow", "transplantation", "congenital", "agranulocytosis", "C0221023#ent", "<e2>", "therapeutic", "uses", "of", "GM-CSF", "and", "G-CSF", "were", "reviewed", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0221023", "name": "C0221023#ent", "pos": [14, 15]}}
{"token": ["Morphine", "sulfate", "and", "C0353148#ent", "<e1>", "chemically", "compatible", "stable", "in", "C1420583#ent", "<e2>", "and", "5", "%", "dextrose", "injection", "for", "36", "hours", "."], "h": {"id": "C0353148", "name": "C0353148#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420583", "name": "C1420583#ent", "pos": [9, 10]}}
{"token": ["Further", "analysis", "of", "the", "2.5-kb", "intergenic", "sequence", "between", "SKI2W", "and", "C3538702#ent", "<e1>", "led", "to", "the", "discovery", "of", "C1414131#ent", "<e2>", "."], "h": {"id": "C3538702", "name": "C3538702#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414131", "name": "C1414131#ent", "pos": [17, 18]}}
{"token": ["These", "data", "imply", "that", "the", "C1416809#ent", "<e1>", "the", "18-amino", "acid", "repeats", "constitutes", "the", "microtubule", "binding", "site", "C1424480#ent", "<e2>", "."], "h": {"id": "C1416809", "name": "C1416809#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424480", "name": "C1424480#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "the", "C1416809#ent", "<e1>", "the", "tubulin", "molecule", "the", "site", "for", "the", "C1424480#ent", "<e2>", "interaction", "."], "h": {"id": "C1416809", "name": "C1416809#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424480", "name": "C1424480#ent", "pos": [14, 15]}}
{"token": ["Tryptic", "digest", "C0011519#ent", "<e1>", "studies", "showed", "the", "presence", "of", "C1705055#ent", "<e2>", "the", "complex", "at", "the", "CRE", "site", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705055", "name": "C1705055#ent", "pos": [9, 10]}}
{"token": ["C0127400#ent", "<e1>", "a", "crucial", "role", "in", "human", "parturition", "and", "C1100642#ent", "<e2>", "PLA(2", ")", ")", "is", "a", "key", "regulator", "of", "the", "production", "of", "these", "compounds", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1100642", "name": "C1100642#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "the", "molecular", "pathogenesis", "C1417031#ent", "<e1>", ",", "we", "screened", "retinal", "yeast", "two-hybrid", "libraries", "with", "the", "RHD", "of", "C1419623#ent", "<e2>", "."], "h": {"id": "C1417031", "name": "C1417031#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419623", "name": "C1419623#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", ",", "a", "PCR", "strategy", "that", "can", "detect", "24", "different", "MSP1", "association", "types", "used", "to", "investigate", "C0002085#ent", "<e1>", "variation", "in", "the", "C1833662#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1833662", "name": "C1833662#ent", "pos": [23, 24]}}
{"token": ["Other", "AE1", "mutations", "have", "been", "linked", "to", "a", "C0796290#ent", "<e1>", "dRTA", "and", "C1387532#ent", "<e2>", "which", "hypofunction", "can", "be", "discerned", "by", "in", "vitro", "."], "h": {"id": "C0796290", "name": "C0796290#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1387532", "name": "C1387532#ent", "pos": [12, 13]}}
{"token": ["A", "method", "for", "quantitative", "determination", "of", "eleven", "sunscreen", "agents", "benzophenone-4,p-amino-benzoic", "acid", ",", "salicylic", "acid", "benzophenone-3,phenyl", "salicylate", ",", "C0094910#ent", "<e1>", "octyl", "dimethyl", "p-amino-benzoate", ",", "isopropyl", "dibenzoylmethane", ",", "C0097513#ent", "<e2>", "octyl", "methoxycinnamate", "octyl", "salicylate", "in", "cosmetic", "products", "described", "."], "h": {"id": "C0094910", "name": "C0094910#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0097513", "name": "C0097513#ent", "pos": [26, 27]}}
{"token": ["Mammalian", "geranylgeranyltransferase", "type", "II", "GGTase-II", ")", "is", "a", "100-kDa", "heterodimer", "that", "catalyzes", "the", "transfer", "of", "two", "C0138843#ent", "<e1>", "groups", "from", "geranylgeranyl", "pyrophosphate", "C-terminal", "cysteine", "residues", "of", "C0018296#ent", "<e2>"], "h": {"id": "C0138843", "name": "C0138843#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [26, 27]}}
{"token": ["Arg196", ",", "which", "is", "missed", "in", "C0039949#ent", "<e1>", ",", "is", "important", "for", "catalysis", "in", "C1417246#ent", "<e2>", "."], "h": {"id": "C0039949", "name": "C0039949#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417246", "name": "C1417246#ent", "pos": [14, 15]}}
{"token": ["MDC", "from", "patients", "with", "active", "hepatitis", "less", "able", "to", "polarize", "naive", "CD4", "T", "cells", "the", "C3540579#ent", "<e1>", "phenotype", ",", "while", "their", "MDC", "and", "C1418706#ent", "<e2>", "primed", "more", "CD4", "T", "cells", "IL-10", "than", "those", "from", "normal", "controls"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418706", "name": "C1418706#ent", "pos": [23, 24]}}
{"token": ["C0006840#ent", "<e1>", "one", "of", "the", "most", "common", "clinical", "features", "of", "C0019693#ent", "<e2>"], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [10, 11]}}
{"token": ["A", "possible", "role", "of", "gamma", "delta", "T", "cells", "human", "autoimmune", "diseases", "as", "rheumatoid", "arthritis", "C0011847#ent", "<e1>", ",", "polymyositis", ",", "sarcoidosis", "and", "acute", "or", "C0393665#ent", "<e2>", "been", "previously", "proposed", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0393665", "name": "C0393665#ent", "pos": [23, 24]}}
{"token": ["These", "findings", "provide", "fundamental", "comparative", "data", "showing", "the", "relationship", "of", "porcine", "hepcidin", "and", "C1825807#ent", "<e1>", "to", "other", "mammalian", "orthologs", "and", "indicate", "that", "C0004623#ent", "<e2>", "influence", "their", "expression", "."], "h": {"id": "C1825807", "name": "C1825807#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [22, 23]}}
{"token": ["Cord", "blood", "banks", "increased", "the", "use", "of", "cord", "blood", "transplants", "C0155017#ent", "<e1>", ")", "for", "patients", "with", "C0018939#ent", "<e2>"], "h": {"id": "C0155017", "name": "C0155017#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [16, 17]}}
{"token": ["Indications", "were", "C0747195#ent", "<e1>", "5", "and", "suspected", "common", "bile", "duct", "C3887938#ent", "<e2>", ")", "stones", "in", "the", "other", "6", "(", "based", "on", "US", "or", "liver", "function", "tests", "or", "both", ")", "."], "h": {"id": "C0747195", "name": "C0747195#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3887938", "name": "C3887938#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "C1333707#ent", "<e1>", "association", "with", "Shc", "and", "activation", "of", "MAPK", "and", "the", "C1138418#ent", "<e2>", "insensitive", "to", "insulin", "stimulation"], "h": {"id": "C1333707", "name": "C1333707#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1138418", "name": "C1138418#ent", "pos": [14, 15]}}
{"token": ["Released", "and", "activated", "C0623362#ent", "<e1>", "are", "controlled", "by", "specific", "tissue", "inhibitors", "C1334706#ent", "<e2>", "(", "TIMP", ")", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [11, 12]}}
{"token": ["The", "PI3K", "inhibitor", "C0251991#ent", "<e1>", ",", "partially", "reversed", "the", "morphological", "transformation", "induced", "by", "C0079972#ent", "<e2>", "and", "resulted", "in", "a", "modest", "stimulation", "of", "apoptosis", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079972", "name": "C0079972#ent", "pos": [13, 14]}}
{"token": ["Acute", "ischemic", "stroke", "patients", "receiving", "C0908244#ent", "<e1>", "may", "also", "be", "exposed", "to", "diuretics", "for", "treatment", "of", "C0018802#ent", "<e2>", "hypertension", "."], "h": {"id": "C0908244", "name": "C0908244#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}}
{"token": ["In", "this", "case", "study", "the", "C0031640#ent", "<e1>", "peak", "which", "contains", "the", "phospholipid", "metabolites", "GPC", "and", "C3810521#ent", "<e2>", ",", "is", "the", "most", "sensitive", "resonance", "in", "response", "to", "RT", "."], "h": {"id": "C0031640", "name": "C0031640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3810521", "name": "C3810521#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "our", "data", "suggest", "that", "interference", "with", "C1334868#ent", "<e1>", "activity", ",", "for", "example", ",", "by", "using", "C3641793#ent", "<e2>", "may", "provide", "a", "positive", "clinical", "benefit", "for", "patients", "with", "Ph-positive", "acute", "lymphoblastic", "leukemia"], "h": {"id": "C1334868", "name": "C1334868#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3641793", "name": "C3641793#ent", "pos": [17, 18]}}
{"token": ["Diseases", "that", "may", "be", "helped", "by", "gene", "therapy", ":", "gastrointestinal", "malignancies", "viral", "hepatitis", "the", "C0684275#ent", "<e1>", ",", "hypercholesterolaemia", ",", "alpha", "1-antitrypsin", "deficiency", "and", "C0025517#ent", "<e2>", "the", "liver", "and", "cystic", "fibrosis"], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [23, 24]}}
{"token": ["C0272286#ent", "<e1>", "result", "in", "post-transfusion", "purpura", "and", "during", "pregnancy", "may", "cause", "C3853779#ent", "<e2>", "NAIT", ")", ",", "with", "a", "frequency", "estimated", "at", "1.3", "per", "1000", "live", "births"], "h": {"id": "C0272286", "name": "C0272286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3853779", "name": "C3853779#ent", "pos": [11, 12]}}
{"token": ["Eosinophils", "have", "been", "reported", "as", "early", "migrating", "cells", "in", "induced", "C0042109#ent", "<e1>", "raising", "the", "possibility", "that", "the", "dual", "action", "C0700480#ent", "<e2>", "may", "provide", "a", "greater", "potential", "benefit", "in", "the", "management", "of", "C0042109#ent", "<e1>"], "h": {"id": "C0042109", "name": "C0042109#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0700480", "name": "C0700480#ent", "pos": [19, 20]}}
{"token": ["C1859598#ent", "<e1>", "is", "associated", "with", "oculomotor", "apraxia", "severe", "sensorimotor", "neuropathy", "choreiform", "movements", "cognitive", "impairment", "and", "C0740279#ent", "<e2>", "an", "early", "age"], "h": {"id": "C1859598", "name": "C1859598#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0740279", "name": "C0740279#ent", "pos": [15, 16]}}
{"token": ["This", "prospective", "study", "performed", "to", "assess", "the", "influence", "of", "limited", "weight-bearing", "on", "the", "outcome", "of", "C0029420#ent", "<e1>", "the", "treatment", "of", "an", "C0029421#ent", "<e2>"], "h": {"id": "C0029420", "name": "C0029420#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029421", "name": "C0029421#ent", "pos": [21, 22]}}
{"token": ["Although", "there", "have", "been", "several", "reports", "of", "C0018799#ent", "<e1>", "adult", "MCTD", ",", "few", "cases", "of", "adult", "MCTD", "having", "C0027059#ent", "<e2>", "associated", "with", "massive", "pericardial", "effusion", "been", "reported", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0027059", "name": "C0027059#ent", "pos": [18, 19]}}
{"token": ["A", "prospective", "double-blind", "study", "designed", "to", "determine", "the", "systemic", "hypertensive", "effects", "of", "topically", "administered", "10", "%", "aqueous", "buffered", "C0031470#ent", "<e1>", "topically", "administered", "1", "%", "aqueous", "tropicamide", "a", "belladonna", "alkaloid", "of", "C0042397#ent", "<e2>"], "h": {"id": "C0031470", "name": "C0031470#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [30, 31]}}
{"token": ["Functional", "analyses", "C1335624#ent", "<e1>", "were", "carried", "out", "by", "introducing", "C2987364#ent", "<e2>", "and", "mutant", "C1335624#ent", "<e1>", "constructs", "into", "AGM", "cultures", "."], "h": {"id": "C1335624", "name": "C1335624#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}}
{"token": ["To", "explore", "whether", "CDKN1B", "might", "be", "a", "direct", "target", "of", "C0919528#ent", "<e1>", "and", "of", "C2674774#ent", "<e2>", ",", "we", "used", "chromatin", "immunoprecipitation", "ChIP", ")", "assays", "and", "luciferase", "reporter", "gene", "assays", "."], "h": {"id": "C0919528", "name": "C0919528#ent", "pos": [10, 11]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C2674774", "name": "C2674774#ent", "pos": [14, 15]}}
{"token": ["MLL", "gene", "leading", "to", "production", "of", "C0919528#ent", "<e1>", "fusion", "proteins", "commonly", "detected", "in", "infant", "leukemia", "patients", ";", "the", "most", "common", "C0919528#ent", "<e1>", "fusion", "associated", "with", "infant", "leukemia", "the", "C2674774#ent", "<e1>", "fusion", "."], "h": {"id": "C0919528", "name": "C0919528#ent", "pos": [6, 7]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C2674774", "name": "C2674774#ent", "pos": [28, 29]}}
{"token": ["While", "heavy", "proteinuria", "C0017668#ent", "<e1>", "FSGS", ")", "are", "well-recognized", "features", "of", "progressive", "C0451718#ent", "<e2>", "adults", ",", "little", "is", "known", "of", "their", "early", "evolution", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0451718", "name": "C0451718#ent", "pos": [12, 13]}}
{"token": ["However", ",", "pharmacotherapy", "with", "antihistamines", ",", "C0039052#ent", "<e1>", "and", ",", "in", "severe", "cases", ",", "C3540725#ent", "<e2>", ",", "is", "most", "frequently", "used", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [14, 15]}}
{"token": ["Transient", "myeloproliferative", "disorder", "C0039494#ent", "<e1>", ")", "is", "an", "uncommon", "C1848862#ent", "<e2>", "strongly", "associated", "with", "abnormalities", "of", "chromosome", "21"], "h": {"id": "C0039494", "name": "C0039494#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [9, 10]}}
{"token": ["Drugs", "that", "may", "cause", "elevation", "of", "the", "DPH", "plasma", "level", "include", "disulfiram", ",", "C0038807#ent", "<e1>", ",", "bishydroxycoumarin", ",", "chloramphenicol", ",", "C1510448#ent", "<e2>", ",", "benzodiazepines", ",", "sulfamethizole", ",", "and", "isoniazid", "."], "h": {"id": "C0038807", "name": "C0038807#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1510448", "name": "C1510448#ent", "pos": [20, 21]}}
{"token": ["B\u00f6rjeson-Forssman-Lehmann", "syndrome", "C3538790#ent", "<e1>", ")", "is", "a", "C0796250#ent", "<e2>", "which", "maps", "by", "linkage", "to", "the", "q26", "region", "of", "the", "human", "X", "chromosome"], "h": {"id": "C3538790", "name": "C3538790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0796250", "name": "C0796250#ent", "pos": [7, 8]}}
{"token": ["C1564139#ent", "<e1>", "been", "purified", "to", "homogeneity", "using", "the", "C0017837#ent", "<e2>", "GST", ")", "fusion", "system"], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [8, 9]}}
{"token": ["C0013264#ent", "<e1>", "DMD", ")", "leads", "to", "progressive", ",", "generalized", "paresis", "and", "to", "C1145670#ent", "<e2>", "the", "second", "decade", "of", "life", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [12, 13]}}
{"token": ["Five", "men", "with", "degenerative", "neuromuscular", "diseases", "three", "with", "amyotrophic", "lateral", "sclerosis", "ALS", "]", "and", "two", "with", "Duchenne's", "muscular", "dystrophy", "C0013264#ent", "<e1>", "]", ")", "who", "had", "C1145670#ent", "<e2>", "treated", "with", "intermittent", "negative", "pressure", "ventilation", "(", "NPV", ")", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [19, 20]}, "relation": "has_manifestation", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [25, 26]}}
{"token": ["Expression", "of", "C3252639#ent", "<e1>", "(", "a", "member", "of", "the", "C1333195#ent", "<e2>", "enzymes", ")", "signaled", "changes", "in", "the", "liver", "associated", "with", "oxidation", "of", "organic", "xenobiotics", "as", "previously", "found", "with", "the", "gill", "."], "h": {"id": "C3252639", "name": "C3252639#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333195", "name": "C1333195#ent", "pos": [9, 10]}}
{"token": ["Two", "C3537368#ent", "<e1>", "genes", "are", "found", "in", "vertebrates", ",", "a", "general", "cell", "isoform", "C1823598#ent", "<e2>", ",", "and", "a", "striated", "muscle-specific", "isoform", "unc45b", "."], "h": {"id": "C3537368", "name": "C3537368#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1823598", "name": "C1823598#ent", "pos": [13, 14]}}
{"token": ["Of", "the", "other", "32", "patients", "with", "minor", "liver", "involvement", "four", "had", "steatosis", ",", "one", "chronic", "active", "hepatitis", "one", "C0019159#ent", "<e1>", "and", "14", "possibly", "early", "C0008313#ent", "<e2>", "unspecific", "reactive", "hepatitis"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008313", "name": "C0008313#ent", "pos": [24, 25]}}
{"token": ["We", "evaluated", "chemosensory", "function", "food", "preferences", "and", "appetite", "in", "88", "patients", "with", "liver", "disease", "those", "with", "C0019159#ent", "<e1>", ",", "cirrhosis", ",", "primary", "biliary", "cirrhosis", "and", "C0008313#ent", "<e2>"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008313", "name": "C0008313#ent", "pos": [25, 26]}}
{"token": ["Two", "homosexual", "HIV1-positive", "male", "patients", "with", "C0034155#ent", "<e1>", "TTP", ")", "were", "found", "to", "have", "past", "history", "of", "C0272286#ent", "<e2>", "ITP", ")", "."], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0272286", "name": "C0272286#ent", "pos": [17, 18]}}
{"token": ["Two", "homosexual", "HIV1-positive", "male", "patients", "with", "thrombotic", "thrombopenic", "purpura", "C0034155#ent", "<e1>", ")", "were", "found", "to", "have", "past", "history", "of", "C0272286#ent", "<e2>", "ITP", ")", "."], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0272286", "name": "C0272286#ent", "pos": [19, 20]}}
{"token": ["Immunohistochemistry", "revealed", "that", "the", "elongated", "mesenchymal", "cells", "central", "axon-like", "structures", "expressed", "vimentin", ",", "S-100", ",", "and", "C1880904#ent", "<e1>", "but", "not", "pancytokeratin", ",", "glial", "fibrillary", "acid", "protein", "and", "the", "neurofilament", "markers", "C1416385#ent", "<e2>", "and", "2F11", "."], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416385", "name": "C1416385#ent", "pos": [30, 31]}}
{"token": ["There", "is", "much", "concern", "about", "potential", "neurodevelopmental", "impairment", "after", "neonatal", "C3536709#ent", "<e1>", "treatment", "for", "C0746102#ent", "<e2>"], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0746102", "name": "C0746102#ent", "pos": [14, 15]}}
{"token": ["There", "is", "growing", "concern", "about", "long-term", "neurodevelopmental", "outcomes", "after", "neonatal", "C3536709#ent", "<e1>", "treatment", "for", "C0746102#ent", "<e2>", "CLD", ")", "."], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0746102", "name": "C0746102#ent", "pos": [14, 15]}}
{"token": ["This", "disorder", "manifests", "as", "scleromyxedema-like", "cutaneous", "skin", "lesions", "without", "associated", "C0030489#ent", "<e1>", ",", "occurring", "in", "the", "setting", "of", "C0035086#ent", "<e2>"], "h": {"id": "C0030489", "name": "C0030489#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [18, 19]}}
{"token": ["By", "Western", "blot", "two", "antibodies", "directed", "against", "two", "different", "portions", "of", "the", "C3853646#ent", "<e1>", "we", "observed", "in", "rat", "muscle", "two", "C1305923#ent", "<e2>", "of", "43", "kDa", ",", "and", "75", "kDa", "respectively", "."], "h": {"id": "C3853646", "name": "C3853646#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [20, 21]}}
{"token": ["In", "this", "study", ",", "we", "have", "prepared", "a", "radioiodinated", "analogue", "of", "the", "selective", "COX-2", "inhibitor", "C0538927#ent", "<e1>", ",", "and", "verified", "its", "binding", "to", "the", "COX-2", "C0014442#ent", "<e2>", "in", "vitro"], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [25, 26]}}
{"token": ["We", "have", "characterized", "signaling", "pathways", "the", "related", "adhesion", "focal", "tyrosine", "kinase", "C1335273#ent", "<e1>", ",", "also", "known", "as", "PYK2", "or", "CAK-beta", ")", "in", "C1707170#ent", "<e2>", "human", "megakaryocytic", "cells"], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1707170", "name": "C1707170#ent", "pos": [22, 23]}}
{"token": ["We", "have", "characterized", "signaling", "pathways", "the", "related", "adhesion", "focal", "tyrosine", "kinase", "RAFTK", ",", "also", "known", "as", "C1335273#ent", "<e1>", "or", "CAK-beta", ")", "in", "C1707170#ent", "<e2>", "human", "megakaryocytic", "cells"], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1707170", "name": "C1707170#ent", "pos": [22, 23]}}
{"token": ["We", "also", "found", "that", "in", "T", "cells", "treated", "with", "mitogenic", "concentrations", "of", "succinyl", "Con", "A", ",", "more", "C1706240#ent", "<e1>", "associated", "with", "cytoskeleton", "than", "did", "H-2", "or", "C1334144#ent", "<e2>"], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334144", "name": "C1334144#ent", "pos": [26, 27]}}
{"token": ["Our", "results", "show", "that", "55", "%", "(", "11", "of", "20", ")", "of", "C0812305#ent", "<e1>", "alleles", "have", "the", "301", "-", "302delAG", "deletion", "in", "familial", "C1705998#ent", "<e2>", "cases", "."], "h": {"id": "C0812305", "name": "C0812305#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705998", "name": "C1705998#ent", "pos": [23, 24]}}
{"token": ["There", "were", "143", "admissions", "for", "bleeding", "duodenal", "ulceration", "102", "for", "C0030920#ent", "<e1>", "47", "for", "chronic", "gastriculceration", "43", "for", "oesophageal", "varices", "33", "for", "C0024633#ent", "<e2>", "45", "for", "less", "common", "causes", "of", "upper", "gastrintestinal", "bleeding"], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024633", "name": "C0024633#ent", "pos": [22, 23]}}
{"token": ["These", "results", "thus", "confirm", "earlier", "in", "vitro", "that", "showed", "that", "C0245179#ent", "<e1>", "is", "predominantly", "C0025517#ent", "<e2>", "by", "CYP3A4", "."], "h": {"id": "C0245179", "name": "C0245179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [14, 15]}}
{"token": ["Instead", ",", "the", "C1423571#ent", "<e1>", "adducted", "bases", "the", "template", "DNA", "as", "points", "of", "C1335439#ent", "<e2>", "fall", "off", "causing", "the", "appearance", "of", "bands", "of", "DNA", "sequencing", "gel", "autoradiographs", "marking", "locations", "where", "adduct", "formation", "have", "occurred", "."], "h": {"id": "C1423571", "name": "C1423571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [13, 14]}}
{"token": ["Serum", "ferritin", "and", "transferrin", "saturation", "failed", "to", "detect", "C0240066#ent", "<e1>", "iron", "therapy", "started", "or", "when", "C1290884#ent", "<e2>", "present", "."], "h": {"id": "C0240066", "name": "C0240066#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [15, 16]}}
{"token": ["Mechanism-based", "inactivation", "of", "human", "C1142644#ent", "<e1>", "L-754,394", ",", "a", "Merck", "compound", "synthesized", "as", "a", "potential", "C0162714#ent", "<e2>", "inhibitor", ",", "was", "investigated", "using", "recombinant", "P450", "3A4"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162714", "name": "C0162714#ent", "pos": [15, 16]}}
{"token": ["Drugs", "inducing", "or", "inhibiting", "C1142644#ent", "<e1>", "and/or", "P-glycoprotein", "may", "influence", "the", "bioavailability", "of", "the", "C0162714#ent", "<e2>", "inhibitors", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162714", "name": "C0162714#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "C0007404#ent", "<e1>", "on", "membrane", "fluidity", "studied", "by", "a", "fluorescence", "polarization", "method", "liposomes", "prepared", "with", "C0000039#ent", "<e2>", "and", "dioleoylphosphatidylcholine", "to", "assess", "their", "pharmacological", "mechanism", "at", "micromol/l", "levels", "found", "in", "human", "body", "fluids", "clinical", "application"], "h": {"id": "C0007404", "name": "C0007404#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000039", "name": "C0000039#ent", "pos": [17, 18]}}
{"token": ["Lyn", ",", "a", "C0033681#ent", "<e1>", "to", "the", "C0282625#ent", "<e2>", "plays", "a", "key", "role", "as", "a", "switch", "molecule", "couples", "the", "B-cell", "receptor", "downstream", "signaling"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [7, 8]}}
{"token": ["Earlier", "we", "demonstrated", "that", "micellar", "solutions", "of", "C1418392#ent", "<e1>", "caused", "endothelium-dependent", "relaxation", "rabbit", "thoracic", "aorta", "bovine", "intrapulmonary", "artery", "vein", "through", "a", "cyclic", "C0010536#ent", "<e2>", "mechanism", "."], "h": {"id": "C1418392", "name": "C1418392#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [22, 23]}}
{"token": ["These", "results", "indicate", "that", "autophosphorylation", "at", "critical", "tyrosine", "residues", "is", "required", "for", "activation", "of", "the", "kinase", "activity", "C3275008#ent", "<e1>", "and", "for", "cell", "transformation", "this", "C1417123#ent", "<e2>", "."], "h": {"id": "C3275008", "name": "C3275008#ent", "pos": [17, 18]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [24, 25]}}
{"token": ["Acquired", "mutations", "the", "C3272445#ent", "<e1>", "in", "the", "hemolysis", "characteristic", "of", "C1418558#ent", "<e2>", "PNH", ")", "."], "h": {"id": "C3272445", "name": "C3272445#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418558", "name": "C1418558#ent", "pos": [10, 11]}}
{"token": ["In", "clinical", "use", "emollients", "employed", "as", "treatments", "for", "C0020757#ent", "<e1>", ",", "xeroderma", "and", "disorders", "of", "keratinization", ",", "C0011615#ent", "<e2>", "psoriasis", ",", "and", "photodamaged", "skin", "."], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [17, 18]}}
{"token": ["Ichthyosis", "vulgaris", "the", "most", "common", "form", "of", "the", "C0020757#ent", "<e1>", "and", "often", "is", "associated", "with", "C0011615#ent", "<e2>"], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [15, 16]}}
{"token": ["Increased", "palmar", "markings", "commonly", "observed", "in", "patients", "with", "C0011615#ent", "<e1>", "C0020757#ent", "<e2>", ",", "while", "normal", "palms", "found", "in", "almost", "all", "patients", "with", "C0011615#ent", "<e1>", "."], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [8, 9]}}
{"token": ["Neither", "quinapril", "nor", "C0072857#ent", "<e1>", "changed", "the", "critical", "micelle", "concentration", "of", "C3273549#ent", "<e2>", ",", "suggesting", "that", "these", "drugs", "do", "not", "directly", "bind", "to", "C3273549#ent", "<e2>", "."], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273549", "name": "C3273549#ent", "pos": [11, 12]}}
{"token": ["C1866282#ent", "<e1>", ",", "the", "gene", "mutated", "variant", "late", "infantile", "NCL", "(", "C1866282#ent", "<e1>", ")", ",", "was", "recently", "cloned", "."], "h": {"id": "C1866282", "name": "C1866282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1866282", "name": "C1866282#ent", "pos": [0, 1]}}
{"token": ["The", "C1866282#ent", "<e1>", "C1866282#ent", "<e1>", "is", "caused", "by", "molecular", "defects", "C1866282#ent", "<e1>", "gene", "coding", "an", "ER", "resident", "transmembrane", "protein", "function", "is", "unknown", "."], "h": {"id": "C1866282", "name": "C1866282#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1866282", "name": "C1866282#ent", "pos": [1, 2]}}
{"token": ["WNV", "causes", "a", "variety", "of", "clinical", "symptoms", "but", "the", "most", "severe", "consequences", "result", "C0007684#ent", "<e1>", "resulting", "in", "C0025289#ent", "<e2>", ",", "encephalitis", ",", "or", "meningoencephalitis", "."], "h": {"id": "C0007684", "name": "C0007684#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [17, 18]}}
{"token": ["Over", "the", "last", "2", "years", "we", "have", "applied", "a", "therapeutic", "regimen", "simultaneous", "use", "of", "cephalexin", "and", "C1450658#ent", "<e1>", "in", "therapy", "for", "infective", "exacerbations", "of", "C0041912#ent", "<e2>", "patients", "."], "h": {"id": "C1450658", "name": "C1450658#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [24, 25]}}
{"token": ["Here", "we", "characterize", "STAT5", "tyrosine", "phosphorylation", "and", "its", "interaction", "with", "C0755322#ent", "<e1>", "during", "early", "C1321914#ent", "<e2>", "differentiation", ";", "these", "processes", "show", "clear", "dependence", "on", "STAT5", "threonine", "phosphorylation", "."], "h": {"id": "C0755322", "name": "C0755322#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [14, 15]}}
{"token": ["The", "results", "suggest", "that", "C3539616#ent", "<e1>", "increases", "[Ca2+]i", "by", "activation", "of", "PLC", ",", "release", "of", "C0011967#ent", "<e2>", ",", "and", "activation", "of", "a", "Ca(2+)-independent", "isoform", "of", "PKC", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [15, 16]}}
{"token": ["C3539616#ent", "<e1>", "also", "elevated", "islet", "C0011967#ent", "<e2>", "content", ",", "which", "should", "lead", "to", "PKC", "activation", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [5, 6]}}
{"token": ["We", "investigated", "the", "effects", "of", "C3539616#ent", "<e1>", "on", "Ca(2+)", "and", "diacylglycerol", "(", "C0011967#ent", "<e2>", ")", "and", "cAMP", "formation", "in", "the", "beta-cell", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [12, 13]}}
{"token": ["A", "patient", "with", "disseminated", "coccidioidomycosis", "had", "pulmonary", "and", "C0037285#ent", "<e1>", "survived", "for", "14", "years", "before", "dying", "of", "C0025289#ent", "<e2>", "due", "to", "Coccidioides", "immitis"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [17, 18]}}
{"token": ["Ectopic", "expression", "of", "the", "C3273820#ent", "<e1>", "(", "also", "known", "as", "C1422043#ent", "<e2>", ")", "gene", "has", "been", "shown", "to", "be", "associated", "with", "cryptic", "t(5;14)(q35;q32", ")", "translocation", "specific", "for", "a", "subtype", "of", "T-ALL", "."], "h": {"id": "C3273820", "name": "C3273820#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1422043", "name": "C1422043#ent", "pos": [10, 11]}}
{"token": ["These", "data", "show", "that", "C0050338#ent", "<e1>", "is", "more", "active", "than", "non-acidic", "C0003209#ent", "<e2>", "such", "as", "tiaramide", "and", "aminopyrine", "."], "h": {"id": "C0050338", "name": "C0050338#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003209", "name": "C0003209#ent", "pos": [11, 12]}}
{"token": ["While", "the", "Christian", "faith", "relies", "on", "God", "'s", "mercy", ",", "it", "also", "imposes", "the", "C0310298#ent", "<e1>", "of", "following", "Christ", "by", "fighting", "against", "C0242830#ent", "<e2>", "and", "misfortune", "."], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0242830", "name": "C0242830#ent", "pos": [22, 23]}}
{"token": ["Taken", "together", ",", "these", "results", "indicate", "that", "C0003873#ent", "<e1>", "can", "significantly", "increase", "gastric", "cancer", "cells", "to", "resist", "C1538265#ent", "<e2>", "cytotoxicity", "by", "means", "of", "a", "cytostatic", "effect", "a", "mechanism", "relating", "to", "cell", "cycle", "regulation"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538265", "name": "C1538265#ent", "pos": [17, 18]}}
{"token": ["This", "study", "was", "designed", "to", "investigate", "the", "effect", "of", "C0003873#ent", "<e1>", "on", "the", "sensitivity", "of", "SC-M1", "cells", "to", "lymphokine-activated", "killer", "C1538265#ent", "<e2>", ")", "activity", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1538265", "name": "C1538265#ent", "pos": [20, 21]}}
{"token": ["Sematilide", "depressed", "the", "delayed", "outward", "K+", "current", "(", "C1416378#ent", "<e1>", ")", "without", "affecting", "the", "C1416587#ent", "<e2>", "current", "and", "the", "L-type", "Ca++", "current", "."], "h": {"id": "C1416378", "name": "C1416378#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416587", "name": "C1416587#ent", "pos": [14, 15]}}
{"token": ["E-4031", "appears", "to", "block", "specifically", "a", "fast", "component", "of", "the", "delayed", "rectifier", "C1416378#ent", "<e1>", ")", ",", "and", "RP", "58866", "is", "a", "reported", "C1416587#ent", "<e2>", "(", "IK1", ")", "blocker", "."], "h": {"id": "C1416378", "name": "C1416378#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416587", "name": "C1416587#ent", "pos": [22, 23]}}
{"token": ["We", "propose", "that", "dietary", "C1425280#ent", "<e1>", "has", "the", "potential", "to", "inhibit", "C1539322#ent", "<e2>", "proliferation", "leading", "to", "retardation", "of", "atherosclerotic", "lesion", "formation", ",", "and", "therefore", "favorable", "modulation", "of", "the", "atherogenic", "process", "."], "h": {"id": "C1425280", "name": "C1425280#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [11, 12]}}
{"token": ["Gastro-oesophageal", "reflux", "could", "be", "one", "of", "the", "causes", "of", "apparently", "cryptogenetic", "bronchiolitis", "obliterans", "C0264383#ent", "<e1>", "and", "all", "patients", "with", "this", "C0035242#ent", "<e2>", "be", "investigated", "for", "gastro-oesophageal", "reflux"], "h": {"id": "C0264383", "name": "C0264383#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [20, 21]}}
{"token": ["Patients", "are", "treated", "with", "cyclohexanedione", "(", "NTBC", ")", ",", "which", "prevents", "accumulation", "of", "FAA", "by", "blocking", "an", "C0014442#ent", "<e1>", "upstream", "of", "C2828026#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2828026", "name": "C2828026#ent", "pos": [21, 22]}}
{"token": ["The", "most", "severe", "of", "these", "is", "type", "I", "tyrosinemia", "which", "is", "caused", "by", "mutations", "affecting", "the", "last", "C0014442#ent", "<e1>", "in", "the", "pathway", ",", "fumarylacetoacetate", "hydrolase", "C2828026#ent", "<e2>", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2828026", "name": "C2828026#ent", "pos": [25, 26]}}
{"token": ["These", "results", "indicate", "that", "C1565427#ent", "<e1>", "might", "play", "a", "role", "in", "a", "signal", "transduction", "system", "C3273436#ent", "<e2>", "in", "glomerular", "mesangial", "cells", "that", "the", "ET-1-induced", "tyrosine", "phosphorylation", "C1565427#ent", "<e1>", "is", "largely", "dependent", "on", "the", "PKC", "pathway", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [4, 5]}}
{"token": ["Contributing", "to", "MRN", "regulatory", "roles", "Nbs1", "harbors", "phosphopeptide", "interacting", "FHA", "and", "BRCT", "domains", ",", "as", "well", "as", "C3711796#ent", "<e1>", "ATM", ")", "kinase", "and", "C3273855#ent", "<e2>", "interaction", "domains", "."], "h": {"id": "C3711796", "name": "C3711796#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3273855", "name": "C3273855#ent", "pos": [23, 24]}}
{"token": ["Overexpressed", "wild-type", "RSP5", "or", "mutant", "rsp5", "C1417679#ent", "<e1>", "with", "lesions", "of", "some", "WW", "domains", "suppress", "growth", "defects", "C1412400#ent", "<e2>", "and", "end3", "cells", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412400", "name": "C1412400#ent", "pos": [17, 18]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "hypothesis", "that", "allelic", "variants", "or", "mutants", "of", "C0024375#ent", "<e1>", "in", "altered", "function", "of", "C1334349#ent", "<e2>", "in", "ALS", "patients", "."], "h": {"id": "C0024375", "name": "C0024375#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334349", "name": "C1334349#ent", "pos": [22, 23]}}
{"token": ["To", "determine", "the", "mechanism", "by", "which", "C0700458#ent", "<e1>", "inhibited", "C0920283#ent", "<e2>", "the", "unwinding", "and", "DNA-dependent", "ATPase", "activities", "of", "C0920283#ent", "<e2>", "measured", "using", "a", "spectrum", "of", "double-", "and", "single-stranded", "DNA", "substrates"], "h": {"id": "C0700458", "name": "C0700458#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0920283", "name": "C0920283#ent", "pos": [9, 10]}}
{"token": ["To", "strengthen", "this", "conclusion", ",", "the", "ability", "of", "C0700458#ent", "<e1>", "to", "inhibit", "the", "DNA-dependent", "ATPase", "of", "C0920283#ent", "<e2>", "determined", "using", "two", "single-stranded", "substrates", "poly(dT", ")", "and", "the", "245-bp", "substrate", "after", "heat", "denaturation"], "h": {"id": "C0700458", "name": "C0700458#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0920283", "name": "C0920283#ent", "pos": [16, 17]}}
{"token": ["To", "describe", "the", "initiation", "and", "evaluation", "of", "a", "nurse", "practitioner", "C3887659#ent", "<e1>", ")", "peer", "review", "program", "a", "group", "of", "15", "C0027341#ent", "<e2>", "practicing", "at", "a", "Veteran's", "Affairs", "Medical", "Center"], "h": {"id": "C3887659", "name": "C3887659#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027341", "name": "C0027341#ent", "pos": [20, 21]}}
{"token": ["Familial", "hemiplegic", "migraine", "C1832884#ent", "<e1>", ")", "is", "an", "autosomal", "dominant", "subtype", "of", "migraine", "with", "C0018989#ent", "<e2>", "during", "the", "aura", "."], "h": {"id": "C1832884", "name": "C1832884#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [14, 15]}}
{"token": ["We", "studied", "interictal", "cortical", "excitability", "with", "magnetic", "stimulation", "controls", ",", "in", "patients", "with", "migraine", "with", "aura", ",", "and", "in", "patients", "with", "familial", "hemiplegic", "migraine", "C1832884#ent", "<e1>", ")", ",", "in", "which", "C0018989#ent", "<e2>", "."], "h": {"id": "C1832884", "name": "C1832884#ent", "pos": [24, 25]}, "relation": "has_manifestation", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [30, 31]}}
{"token": ["Two", "major", "end-points", "of", "C0034417#ent", "<e1>", "induced", "neurotoxicity", "are", "both", "circling", "behavior", "CB", ")", "and", "lipid", "peroxidation", "C2239920#ent", "<e2>", ")", "."], "h": {"id": "C0034417", "name": "C0034417#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2239920", "name": "C2239920#ent", "pos": [17, 18]}}
{"token": ["The", "gene", "responsible", "for", "WS", "has", "been", "identified", "as", "C0388246#ent", "<e1>", ",", "a", "member", "of", "the", "RecQ", "family", "C1333949#ent", "<e2>"], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [18, 19]}}
{"token": ["By", "expressing", "C0388246#ent", "<e1>", "isoforms", "impaired", "in", "either", "C1333949#ent", "<e2>", "or", "exonuclease", "activity", "defective", "cells", ",", "we", "identified", "WRN", "helicase", "activity", "as", "the", "function", "required", "for", "maintaining", "the", "stability", "of", "fragile", "sites"], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [8, 9]}}
{"token": ["C0388246#ent", "<e1>", "encodes", "a", "multifunctional", "nuclear", "protein", "3'-->5", "'", "exonuclease", "and", "3'-->5", "'", "C1333949#ent", "<e2>", "activities", "."], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [13, 14]}}
{"token": ["We", "have", "recently", "shown", "that", "C1423775#ent", "<e1>", "overexpression", "blocks", "BFA-induced", "redistribution", "of", "the", "AP-1", "complex", "not", "C1420709#ent", "<e2>", "membrane", "tubulation"], "h": {"id": "C1423775", "name": "C1423775#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [16, 17]}}
{"token": ["Candida", "albicans", "peritonitis", "in", "a", "48-year-old", "man", "with", "a", "C0341163#ent", "<e1>", "subsequently", "was", "treated", "with", "intravenous", "amphotericin", "The", "C1254351#ent", "<e2>", "penetrated", "well", "into", "the", "inflamed", "peritoneal", "cavity", "eradicated", "the", "organism", "from", "the", "peritoneal", "fluid"], "h": {"id": "C0341163", "name": "C0341163#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["Patients", "with", "C0032266#ent", "<e1>", "been", "reported", "to", "excrete", "excessive", "C0919509#ent", "<e2>", "because", "of", "a", "lack", "of", "H2-consuming", "intestinal", "bacteria", "."], "h": {"id": "C0032266", "name": "C0032266#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [9, 10]}}
{"token": ["Like", "the", "C1883559#ent", "<e1>", "two", "altered", "C1308278#ent", "<e2>", "with", "more", "hydrophilic", "Tat-", "or", "Sec-dependent", "signal", "peptides", "were", "both", "able", "to", "restore", "the", "motility", "of", "the", "DeltafliP", "mutant", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1308278", "name": "C1308278#ent", "pos": [6, 7]}}
{"token": ["The", "mutant", "spores", "were", "viable", "but", "sensitive", "to", "lytic", "C3540772#ent", "<e1>", "(", "glusulase", "or", "C0014106#ent", "<e2>", ")", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014106", "name": "C0014106#ent", "pos": [14, 15]}}
{"token": ["Using", "immunohistochemical", "method", "we", "confirmed", "increased", "protein", "expression", "C1420091#ent", "<e1>", "in", "the", "C0282556#ent", "<e2>", "subject", "with", "restricted", "localization", "to", "goblet", "cells"], "h": {"id": "C1420091", "name": "C1420091#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [12, 13]}}
{"token": ["Urinary", "lithiasis", "hypercalciuria", "and", "C1840402#ent", "<e1>", "are", "strictly", "related", "diseases", ",", "and", "the", "urologist", "diagnoses", "C0221002#ent", "<e2>", "PHP", ")", "in", "the", "majority", "of", "cases", "."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [15, 16]}}
{"token": ["The", "diversity", "of", "bone", "changes", "in", "C1840402#ent", "<e1>", ",", "similar", "to", "that", "of", "C0221002#ent", "<e2>", "is", "without", "doubt", "dependent", "on", "the", "degree", "of", "renal", "insensitivity", "PTH", "through", "the", "inactivation", "of", "vitamin", "D."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [13, 14]}}
{"token": ["The", "lithium-induced", "phosphorylation", "of", "cdc2", "and", "G2/M", "arrest", "abrogated", "largely", "by", "SB218078", ",", "a", "potent", "C0659150#ent", "<e1>", "inhibitor", ",", "as", "well", "as", "by", "C0659150#ent", "<e1>", "siRNA", "or", "the", "over-expression", "of", "C0031727#ent", "<e1>", "C0659150#ent", "<e1>", "."], "h": {"id": "C0659150", "name": "C0659150#ent", "pos": [15, 16]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [30, 31]}}
{"token": ["The", "structural", "models", "these", "ligands", "in", "the", "C0659150#ent", "<e1>", "ATP-binding", "site", "facilitate", "further", "medicinal", "chemistry", "targeting", "this", "C0031727#ent", "<e2>", "."], "h": {"id": "C0659150", "name": "C0659150#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["The", "expression", "of", "cytotactin", ",", "the", "cytotactin-binding", "(", "CTB", ")", "C1418888#ent", "<e1>", ",", "and", "the", "C1413393#ent", "<e2>", "N-CAM", ",", "was", "examined", "during", "the", "development", "of", "the", "avian", "endocardial", "cushion", "tissue", "ECT", ")", "."], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413393", "name": "C1413393#ent", "pos": [15, 16]}}
{"token": ["Without", "C0005859#ent", "<e1>", "treatment", ",", "individuals", "with", "the", "C0919534#ent", "<e2>", "null", "genotype", "no", "significant", "difference", "in", "frequencies", "of", "damaged", "cells", "by", "comparison", "to", "individuals", "with", "the", "C0919534#ent", "<e2>", "genotype", "."], "h": {"id": "C0005859", "name": "C0005859#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0919534", "name": "C0919534#ent", "pos": [8, 9]}}
{"token": ["A", "polymorphism", "due", "to", "loss", "of", "a", "recognition", "site", "the", "C0012906#ent", "<e1>", "identified", "in", "eight", "of", "42", "patients", "with", "C0006267#ent", "<e2>", "and", "nine", "of", "49", "patients", "with", "pulmonary", "emphysema", "none", "of", "whom", "had", "alpha", "1-antitrypsin", "deficiency"], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [19, 20]}}
{"token": ["In", "children", ",", "C0069739#ent", "<e1>", "10", "-", "20", "mg/kg/day", "has", "been", "used", "to", "treat", "C3495559#ent", "<e2>"], "h": {"id": "C0069739", "name": "C0069739#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [14, 15]}}
{"token": ["The", "interaction", "between", "dextromethorphan", ",", "and", "its", "pharmacologically", "active", "metabolite", "C0011821#ent", "<e1>", ",", "and", "norpethidine", ",", "a", "toxic", "metabolite", "C0025376#ent", "<e2>", ",", "was", "examined", "in", "rats", "."], "h": {"id": "C0011821", "name": "C0011821#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025376", "name": "C0025376#ent", "pos": [19, 20]}}
{"token": ["These", "results", "demonstrate", "that", "there", "is", "a", "RAD51-", "and", "RAD54-independent", "BIR", "pathway", "that", "requires", "RAD59", ",", "C1420733#ent", "<e1>", ",", "RAD50", ",", "and", "presumably", "C3273855#ent", "<e2>", "and", "XRS2", "."], "h": {"id": "C1420733", "name": "C1420733#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3273855", "name": "C3273855#ent", "pos": [23, 24]}}
{"token": ["C0001911#ent", "<e1>", ",", "a", "new", "C0003158#ent", "<e2>", "evaluated", "in", "Malaysia", "in", "91", "patients", ",", "with", "single", "or", "mixed", "infections", "Ascaris", ",", "Trichuris", ",", "and", "hookworm", "."], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003158", "name": "C0003158#ent", "pos": [5, 6]}}
{"token": ["This", "case", "shows", "that", "spontaneous", "C0038525#ent", "<e1>", "occur", "in", "children", "with", "C0403414#ent", "<e2>", "should", "be", "suspected", "when", "meningeal", "manifestations", "are", "prominent", "."], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0403414", "name": "C0403414#ent", "pos": [11, 12]}}
{"token": ["The", "paxillin", "LD4", "domain", "mediates", "this", "reduction", "in", "Rac", "activity", "recruiting", "an", "ADP-ribosylation", "factor", "GTPase-activating", "protein", "Arf-GAP", ")", "that", "decreases", "C0022660#ent", "<e1>", "thereby", "inhibiting", "C0285558#ent", "<e2>", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [24, 25]}}
{"token": ["Pelvic", "inflammatory", "disease", "C1417406#ent", "<e1>", ")", ",", "a", "bacterial", "infection", "in", "the", "C0269173#ent", "<e2>", "is", "increasingly", "encountered", "among", "adolescents", "seen", "by", "the", "pediatrician", "."], "h": {"id": "C1417406", "name": "C1417406#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0269173", "name": "C0269173#ent", "pos": [12, 13]}}
{"token": ["We", "therefore", "investigated", "this", "candidate", "C0079429#ent", "<e1>", "in", "selected", "diabetic", "and", "C0362046#ent", "<e2>", "Pimas", "and", "found", "no", "variants", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "the", "study", "indicates", "that", "a", "significant", "number", "of", "patients", "with", "C0282488#ent", "<e1>", "be", "expected", "to", "benefit", "from", "treatment", "with", "C0524684#ent", "<e2>"], "h": {"id": "C0282488", "name": "C0282488#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0524684", "name": "C0524684#ent", "pos": [21, 22]}}
{"token": ["Studies", "of", "the", "mechanisms", "and", "causes", "of", "C0282488#ent", "<e1>", "IC", ")", "and", "of", "the", "properties", "of", "C0524684#ent", "<e2>", "provided", "a", "scientific", "rationale", "using", "C0524684#ent", "<e2>", "treat", "IC", "."], "h": {"id": "C0282488", "name": "C0282488#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0524684", "name": "C0524684#ent", "pos": [16, 17]}}
{"token": ["Respiratory", "chain", "carriers", "other", "than", "cytochromes", "a", "and", "a(3", ")", "and", "the", "ATPase", "complex", "present", "at", "near", "wild-type", "levels", "in", "C1420321#ent", "<e1>", "mutants", ",", "indicating", "that", "the", "mutations", "specifically", "affect", "C0010760#ent", "<e2>"], "h": {"id": "C1420321", "name": "C1420321#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010760", "name": "C0010760#ent", "pos": [30, 31]}}
{"token": ["C1335873#ent", "<e1>", "also", "binds", "to", "IFNaR2", "in", "a", "C0907533#ent", "<e2>", ",", "phosphorylation-independent", "manner", "."], "h": {"id": "C1335873", "name": "C1335873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}}
{"token": ["The", "other", "class", ",", "including", "the", "high", "affinity", "tryptophan", "permease", ",", "C1335873#ent", "<e1>", ",", "consists", "of", "the", "so-called", "C0907533#ent", "<e2>", "permeases", "."], "h": {"id": "C1335873", "name": "C1335873#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "the", "potential", "use", "of", "C3828567#ent", "<e1>", "inhibitors", "to", "treat", "C0007682#ent", "<e2>", "such", "as", "major", "depressive", "disorders", "has", "received", "less", "attention", "."], "h": {"id": "C3828567", "name": "C3828567#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [12, 13]}}
{"token": ["C0010762#ent", "<e1>", "produced", "a", "marked", "detrusor", "hyperreflexia", "was", "abolished", "by", "C0006931#ent", "<e2>", "pretreatment", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [10, 11]}}
{"token": ["C1824675#ent", "<e1>", "was", "first", "described", "as", "C3812693#ent", "<e2>", ",", "a", "gene", "that", "is", "overexpressed", "in", "neutrophils", "from", "approximately", "95", "%", "of", "patients", "with", "polycythemia", "vera", "from", "about", "half", "of", "patients", "with", "essential", "thrombocythemia"], "h": {"id": "C1824675", "name": "C1824675#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3812693", "name": "C3812693#ent", "pos": [6, 7]}}
{"token": ["C1824675#ent", "<e1>", "is", "polymorphic", "and", "has", "at", "least", "two", "alleles", ",", "C3812693#ent", "<e2>", "and", "NB1", "."], "h": {"id": "C1824675", "name": "C1824675#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3812693", "name": "C3812693#ent", "pos": [11, 12]}}
{"token": ["Neurodegenerative", "diseases", "affect", "cognition", ",", "e.g.", "Alzheimer's", "disease", "AD", ")", ",", "dementia", "with", "Lewy", "bodies", "C0011269#ent", "<e1>", "or", "different", "aspects", "of", "the", "motor", "system", "e.g.", ",", "C0002736#ent", "<e2>", "Parkinson's", "disease", "ataxic", "disorders", "."], "h": {"id": "C0011269", "name": "C0011269#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [26, 27]}}
{"token": ["Although", "the", "cause", "may", "be", "inadequate", "blood", "flow", "a", "toxic", "insult", "to", "the", "renal", "tubules", "or", "a", "combination", "thereof", "--", "C1512608#ent", "<e1>", "often", "underlies", "C0022660#ent", "<e2>"], "h": {"id": "C1512608", "name": "C1512608#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [24, 25]}}
{"token": ["Misdiagnosis", "of", "sexual", "abuse", "arise", "in", "cases", "of", "vulvar", "and/or", "C0031028#ent", "<e1>", "as", "lichen", "sclerosus", "atrophicus", ",", "Behcet's", "syndrome", "bullous", "diseases", "C0011616#ent", "<e2>", "or", "neoplastic", "lesions"], "h": {"id": "C0031028", "name": "C0031028#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011616", "name": "C0011616#ent", "pos": [21, 22]}}
{"token": ["Monocytes", "(", "C1333690#ent", "<e1>", "were", "simultaneously", "preincubated", "with", "salicylazosulfapyridine", "(", "C0073966#ent", "<e2>", ")", "(", "SAZ", ")", ",", "0.78", "-", "12.5", "mM", ",", "and", "lipopolysaccharide", "from", "E.", "coli", "1", "X", "10(-9", ")", "g/ml", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0073966", "name": "C0073966#ent", "pos": [10, 11]}}
{"token": ["To", "study", "its", "possible", "mechanism", "of", "carcinogenesis", "in", "animals", ",", "expression", "of", "protooncogene", "c-myc", "functional", "C0017837#ent", "<e1>", "GST-P", ")", "in", "the", "liver", "tissues", "rats", "chronically", "exposed", "to", "C0066286#ent", "<e2>", "was", "detected", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0066286", "name": "C0066286#ent", "pos": [27, 28]}}
{"token": ["Here", "we", "explored", "this", "system", "for", "regulated", "expression", "of", "human", "aromatic", "L-amino", "acid", "decarboxylase", "C4042618#ent", "<e1>", ")", "in", "a", "rodent", "model", "C1868675#ent", "<e2>"], "h": {"id": "C4042618", "name": "C4042618#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1868675", "name": "C1868675#ent", "pos": [21, 22]}}
{"token": ["A", "progression", "occurred", "8", "months", "later", "and", "the", "patient", "was", "treated", "unsuccessfully", "with", "C0039286#ent", "<e1>", ",", "LHRH", ",", "and", "later", "with", "high", "dose", "C0025677#ent", "<e2>", "and", "carboplatin", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [23, 24]}}
{"token": ["Twelve", ",", "who", "had", "previously", "experienced", "hematuria", "with", "C0020823#ent", "<e1>", ",", "received", "a", "median", "of", "3.5", "more", "cycles", "of", "C1170010#ent", "<e2>", "."], "h": {"id": "C0020823", "name": "C0020823#ent", "pos": [8, 9]}, "relation": "part_of", "t": {"id": "C1170010", "name": "C1170010#ent", "pos": [19, 20]}}
{"token": ["The", "simultaneous", "occurrence", "of", "C0041466#ent", "<e1>", "a", "child", "with", "an", "C0271561#ent", "<e2>", "treated", "with", "Somatrem", ",", "produced", "a", "lack", "of", "response", "to", "the", "recombinant", "hormone", "evidenced", "by", "a", "lack", "of", "growth", "during", "the", "acute", "disease"], "h": {"id": "C0041466", "name": "C0041466#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0271561", "name": "C0271561#ent", "pos": [10, 11]}}
{"token": ["BCNU", "and", "C0687700#ent", "<e1>", "both", "produced", "growth", "delay", "C1420740#ent", "<e2>", "at", "doses", "below", "the", "ID50", "of", "the", "monolayer", "culture"], "h": {"id": "C0687700", "name": "C0687700#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420740", "name": "C1420740#ent", "pos": [8, 9]}}
{"token": ["This", "study", "aimed", "at", "determining", "whether", "an", "NO", "synthase", "C0669372#ent", "<e1>", ")", "is", "present", "at", "the", "C0751950#ent", "<e2>", "notably", "in", "perisynaptic", "Schwann", "cells", "the", "glial", "cells", "this", "synapse", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [16, 17]}}
{"token": ["Two", "patients", "with", "C1456383#ent", "<e1>", ",", "CSF", "protein", "content", "above", "75", "mg/dl", ",", "and", "C0030489#ent", "<e2>", "had", "lymphoma", "."], "h": {"id": "C1456383", "name": "C1456383#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030489", "name": "C0030489#ent", "pos": [14, 15]}}
{"token": ["HAB-40", "cells", "in", "microassays", "exhibited", "a", "marked", "dose-dependent", "incorporation", "of", "[3H]thymidine", "in", "response", "to", "BCGF", "in", "the", "absence", "of", "any", "exogenous", "C0304402#ent", "<e1>", "such", "as", "anti-IgM", "or", "C1318973#ent", "<e2>", "SAC", ")", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1318973", "name": "C1318973#ent", "pos": [27, 28]}}
{"token": ["Adoptive", "transfer", "P0-reactive", "T", "cells", "generated", "from", "C1456795#ent", "<e1>", "mice", "induced", "C0021847#ent", "<e2>", "in", "four", "of", "six", "NOD.SCID", "mice", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [11, 12]}}
{"token": ["Modification", "of", "cell", "surface", "carbohydrates", "at", "mucosal", "surfaces", "determined", "by", "the", "C1414863#ent", "<e1>", "underlie", "the", "protective", "association", "heterosexual", "C0019693#ent", "<e2>"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [18, 19]}}
{"token": ["Among", "the", "12", "adult", "patients", "with", "ascites", ",", "seven", "had", "C0023895#ent", "<e1>", "three", "with", "cirrhosis", "and", "four", "with", "C0268381#ent", "<e2>", ")", ",", "and", "two", "had", "right-sided", "congestive", "heart", "failure"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268381", "name": "C0268381#ent", "pos": [18, 19]}}
{"token": ["The", "description", "of", "a", "syndrome", "similar", "to", "the", "C0027849#ent", "<e1>", "occurring", "after", "levodopa", "withdrawal", "in", "a", "C0242422#ent", "<e2>", "patient", "is", "reported", "."], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [16, 17]}}
{"token": ["Under", "the", "conditions", ",", "oxidizing", "reagents", "not", "enhance", "the", "increase", "in", "C1333201#ent", "<e1>", "activity", "by", "C0022020#ent", "<e2>", "or", "the", "basal", "activity", "unstimulated", "cells", "."], "h": {"id": "C1333201", "name": "C1333201#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022020", "name": "C0022020#ent", "pos": [15, 16]}}
{"token": ["We", "suggest", "that", "the", "C1413753#ent", "<e1>", "mutation", "leads", "to", "deficient", "transcription", "of", "the", "C1709289#ent", "<e2>", "thus", "to", "deficient", "repair", "of", "8-oxoguanine", "in", "DNA", "."], "h": {"id": "C1413753", "name": "C1413753#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709289", "name": "C1709289#ent", "pos": [13, 14]}}
{"token": ["Activation", "of", "RPK", "with", "either", "C0960371#ent", "<e1>", "or", "rabbit", "C1414499#ent", "<e2>", "active", ")", "occurs", "by", "limited", "proteolytic", "cleavage", "producing", "two", "disulfide-linked", "polypeptide", "chains", "with", "molecular", "weights", "55,000", "and", "35,000", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414499", "name": "C1414499#ent", "pos": [9, 10]}}
{"token": ["This", "report", "describes", "a", "patient", "with", "mild", "language", "delay", "mental", "retardation", "who", "was", "found", "to", "have", "C0751748#ent", "<e1>", "her", "presentation", "with", "C0085584#ent", "<e2>", "chorea", "shortly", "after", "initiation", "of", "valproate", "therapy"], "h": {"id": "C0751748", "name": "C0751748#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [21, 22]}}
{"token": ["Non-ketotic", "hyperglycinemia", "NKH", ")", "has", "been", "differentiated", "as", "an", "C3899988#ent", "<e1>", "form", "of", "the", "C0268579#ent", "<e2>", "with", "a", "defect", "in", "the", "glycine-cleavage", "system", "accumulation", "of", "glycine", "in", "all", "body", "fluids"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268579", "name": "C0268579#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "ICAD-L(2TEV", ")", "was", "functional", "as", "a", "C1332924#ent", "<e1>", "for", "the", "production", "of", "active", "C3813548#ent", "<e2>", "in", "DT40", "cells", "."], "h": {"id": "C1332924", "name": "C1332924#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3813548", "name": "C3813548#ent", "pos": [15, 16]}}
{"token": ["The", "human", "alpha-", "and", "C2827561#ent", "<e1>", "been", "activated", "in", "C1417108#ent", "<e2>", "human", "fibroblast", "cell", "."], "h": {"id": "C2827561", "name": "C2827561#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417108", "name": "C1417108#ent", "pos": [9, 10]}}
{"token": ["To", "define", "molecular", "determinants", "of", "the", "developmentally", "dynamic", "histone", "acetylation", "of", "the", "C2827561#ent", "<e1>", "we", "compared", "acetylation", "of", "the", "locus", "in", "C1417108#ent", "<e2>", "and", "CB3", "erythroleukemia", "cells"], "h": {"id": "C2827561", "name": "C2827561#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417108", "name": "C1417108#ent", "pos": [21, 22]}}
{"token": ["C0008513#ent", "<e1>", "occurred", "in", "a", "young", "man", "whose", "long-standing", "C0085436#ent", "<e2>", "been", "identified", "and", "treated", "."], "h": {"id": "C0008513", "name": "C0008513#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085436", "name": "C0085436#ent", "pos": [9, 10]}}
{"token": ["Prevention", "of", "biotinylated", "subunit", ",", "but", "not", "C0086140#ent", "<e1>", "translocation", "into", "neurites", "by", "nocodazole", "confirmed", "that", "microinjected", "C0599220#ent", "<e2>", "did", "not", "enter", "axons", "merely", "due", "to", "diffusion", "or", "injection-based", "pressure", "."], "h": {"id": "C0086140", "name": "C0086140#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [17, 18]}}
{"token": ["The", "overall", "structure", "of", "PelA", "does", "not", "adopt", "the", "characteristic", "parallel", "beta-helix", "fold", "displayed", "by", "pectate", "lyases", "from", "C0032594#ent", "<e1>", "PL", ")", "families", "C1426501#ent", "<e2>", ",", "PL3", "and", "PL9", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1426501", "name": "C1426501#ent", "pos": [23, 24]}}
{"token": ["Evaluate", "the", "clinical", "efficacy", "quality", "of", "life", "C0021186#ent", "<e1>", "in", "patients", "with", "mild", "and", "moderate", "C0020538#ent", "<e2>", "C0021186#ent", "<e1>", "."], "h": {"id": "C0021186", "name": "C0021186#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [15, 16]}}
{"token": ["A", "51-year-old", "man", "has", "been", "sequentially", "treated", "for", "two", "years", "with", "atenolol", ",", "C0021186#ent", "<e1>", ",", "enalapril", ",", "and", "fosinopril", "due", "to", "C0020538#ent", "<e2>"], "h": {"id": "C0021186", "name": "C0021186#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [22, 23]}}
{"token": ["C0132555#ent", "<e1>", "NOS", ")", "and", "C0024708#ent", "<e2>", "Mn-SOD", ")", "mRNA", "expressions", "are", "simultaneously", "induced", "by", "these", "stimulants", "in", "rat", "VSMCs", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024708", "name": "C0024708#ent", "pos": [5, 6]}}
{"token": ["Earlier", "studies", "have", "indicated", "that", "lysosomal", "enzymes", "such", "as", "C0699919#ent", "<e1>", "redistributed", "within", "pancreatic", "acinar", "cells", "the", "early", "stages", "both", "diet-", "and", "secretagogue-induced", "C0001339#ent", "<e2>"], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [23, 24]}}
{"token": ["The", "sensory", "innervation", "of", "intracranial", "vessels", "in", "the", "trigeminal", "ganglion", "calcitonin", "gene-related", "peptide", "C1705783#ent", "<e1>", ")", ",", "substance", "P", "SP", ")", "and", "pituitary", "adenylate", "cyclase", "activating", "peptide", "C1412228#ent", "<e2>", ")", "as", "frequent", "neuronal", "messengers", "."], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [27, 28]}}
{"token": ["In", "these", "fibres", ",", "C1705783#ent", "<e1>", "coexists", "with", "C1412228#ent", "<e2>", "PACAP", ")", "."], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [8, 9]}}
{"token": ["Although", "individual", "residues", "in", "both", "S5", "and", "C1419024#ent", "<e1>", "were", "found", "to", "affect", "C0000477#ent", "<e2>", "blockade", ",", "the", "most", "effective", "change", "was", "L327F", "in", "S5", "."], "h": {"id": "C1419024", "name": "C1419024#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [13, 14]}}
{"token": ["The", "only", "complication", "noted", "with", "the", "application", "of", "a", "C0885378#ent", "<e1>", "patch", "was", "C0018681#ent", "<e2>", "experienced", "by", "six", "(", "21", "%", ")", "patients", "."], "h": {"id": "C0885378", "name": "C0885378#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [13, 14]}}
{"token": ["C0885378#ent", "<e1>", "(", "NTG", ")", "administration", "commonly", "causes", "a", "C0018681#ent", "<e2>", "with", "some", "features", "similar", "to", "those", "of", "a", "migraine", "."], "h": {"id": "C0885378", "name": "C0885378#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [9, 10]}}
{"token": ["The", "pharmacodynamic", "effects", "C0885378#ent", "<e1>", "and", "sumatriptan", "on", "middle", "cerebral", "artery", "blood", "flow", "velocity", "MCAv", ")", "and", "C0018681#ent", "<e2>", "studied", "in", "10", "healthy", "male", "volunteers", "."], "h": {"id": "C0885378", "name": "C0885378#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [17, 18]}}
{"token": ["A", "diacylglycerol", ",", "dioctanoylglycerol", ",", "but", "not", "thapsigargin", "or", "depolarization", "with", "potassium", ",", "mimicked", "the", "C1415501#ent", "<e1>", "response", "with", "regard", "to", "C1333909#ent", "<e2>", "+", "sensitivity", "."], "h": {"id": "C1415501", "name": "C1415501#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [21, 22]}}
{"token": ["Experimental", "autoimmune", "neuritis", "EAN", ")", "is", "a", "T", "cell", "C0004364#ent", "<e1>", "the", "peripheral", "nervous", "system", "serves", "as", "an", "animal", "model", "the", "acute", "inflammatory", "demyelinating", "polyradiculoneuropathy", "C0018378#ent", "<e2>", "GBS", ")", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [25, 26]}}
{"token": ["C3265462#ent", "<e1>", "CpB", ")", "as", "well", "as", "thrombin-activated", "fibrinolysis", "inhibitor", "TAFIa", ")", "and", "C0007075#ent", "<e2>", "CpN", ")", "rapidly", "reduced", "AIIt-stimulated", "plasminogen", "activation", "by", "80", "%", "."], "h": {"id": "C3265462", "name": "C3265462#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0007075", "name": "C0007075#ent", "pos": [13, 14]}}
{"token": ["We", "could", "pull", "out", "C2826592#ent", "<e1>", "GST-PDCD4", ",", "but", "eIF4E", "did", "not", "interact", "with", "C2986636#ent", "<e2>", "."], "h": {"id": "C2826592", "name": "C2826592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986636", "name": "C2986636#ent", "pos": [14, 15]}}
{"token": ["The", "drug", "recirculates", "and", ",", "at", "the", "end", "of", "the", "treatment", "period", ",", "it", "is", "C0600142#ent", "<e1>", "from", "the", "C0030196#ent", "<e2>", "and", "the", "circulation", "is", "re-established", "."], "h": {"id": "C0600142", "name": "C0600142#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [19, 20]}}
{"token": ["Optimal", "initiation", "occurs", "in", "the", "presence", "of", "the", "cellular", "transcription", "factors", "NFI", "and", "C1332801#ent", "<e1>", "and", "the", "viral", "DNA", "binding", "protein", "C1415740#ent", "<e2>", ")", "."], "h": {"id": "C1332801", "name": "C1332801#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [21, 22]}}
{"token": ["Treatment", "of", "rats", "with", "the", "LOX-1", "antibody", "prevented", "I/R-induced", "upregulation", "of", "C1417947#ent", "<e1>", "and", "reduced", "C0166027#ent", "<e2>", "and", "adhesion", "molecule", "expression", "as", "well", "as", "leukocyte", "recruitment", "."], "h": {"id": "C1417947", "name": "C1417947#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [15, 16]}}
{"token": ["The", "chemokine", "CXC", "ligand", "8", "(CXCL8)/IL-8", "and", "related", "C0243192#ent", "<e1>", "recruit", "and", "activate", "polymorphonuclear", "cells", "binding", "the", "CXC", "chemokine", "receptor", "1", "C1334125#ent", "<e2>", ")", "and", "CXCR2", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334125", "name": "C1334125#ent", "pos": [21, 22]}}
{"token": ["Here", ",", "we", "show", "that", "transcription", "of", "C1528301#ent", "<e1>", "is", "increased", "in", "several", "animal", "models", "C3160718#ent", "<e2>", "and", "a", "transgenic", "model", "amyotrophic", "lateral", "sclerosis", "ALS", ")", "."], "h": {"id": "C1528301", "name": "C1528301#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [15, 16]}}
{"token": ["Recent", "evidence", "for", "the", "involvement", "of", "C1528301#ent", "<e1>", "in", "the", "early", "pathogenesis", "of", "MPTP-induced", "Parkinson's", "disease", "C3160718#ent", "<e2>", ")", "prompted", "us", "to", "investigate", "in", "more", "detail", "its", "expression", "and", "role", "in", "animal", "models", "different", "neurodegenerative", "diseases"], "h": {"id": "C1528301", "name": "C1528301#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [16, 17]}}
{"token": ["After", "blood", "pressure", "control", "phenoxybenzamine", "and", "C0014027#ent", "<e1>", ",", "doxazosin", "was", "used", "successfully", "as", "the", "preoperative", "C0001640#ent", "<e2>", "surgical", "tumor", "resection"], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "C0014027#ent", "<e1>", "on", "the", "cardiovascular", "responses", "by", "either", "the", "C0001640#ent", "<e2>", "phenylephrine", "or", "the", "alpha", "2-adrenoceptor", "xylazine", "were", "determined", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [12, 13]}}
{"token": ["Isolated", "perfused", "male", "Sprague-Dawley", "rat", "tail", "artery", "segments", "were", "used", "to", "investigate", "interactions", "between", "the", "alpha-1-adrenoceptor", "antagonist", "doxazosin", ",", "and", "the", "angiotensin", "converting", "enzyme", "(ACE)", "inhibitor", "C0014027#ent", "<e1>", ",", "using", "phenylephrine", "(", "PE", ")", "as", "the", "C0001640#ent", "<e2>"], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [36, 37]}}
{"token": ["Ultrastructural", "study", "leukocytes", "confirmed", "DCS", "in", "a", "child", "homozygous", "for", "a", "novel", "ABHD5", "mutation", ",", "with", "ichthyosis", ",", "developmental", "delay", "and", "steatohepatitis", "with", "C0023890#ent", "<e1>", ",", "manifest", "only", "as", "elevated", "C0002594#ent", "<e2>", "levels", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [30, 31]}}
{"token": ["In", "C0023890#ent", "<e1>", "PHL", "correlated", "with", "the", "degree", "of", "C0002594#ent", "<e2>", "well", "as", "serum", "gammaglobulin"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [9, 10]}}
{"token": ["Pre-treatment", "with", "10(-2)M", "and", "10(-1)M", "97", "-", "139", "completely", "prevented", "the", "C0033036#ent", "<e1>", "increase", "induced", "by", "10(-5)M", "and", "10(-4)M", "C3273436#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [19, 20]}}
{"token": ["We", "suggest", "that", ",", "since", "THC", "is", "a", "useful", "C1516021#ent", "<e1>", "patients", "having", "refractory", "C0549410#ent", "<e2>", "existing", "restrictions", "prohibiting", "its", "therapeutic", "use", "should", "promptly", "be", "eased", "."], "h": {"id": "C1516021", "name": "C1516021#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0549410", "name": "C0549410#ent", "pos": [14, 15]}}
{"token": ["This", "animal", "model", "us", "to", "study", "in", "vivo", "tissue-specific", ",", "C1522417#ent", "<e1>", "promoter-controlled", ",", "regulation", "of", "the", "expression", "of", "the", "C1413865#ent", "<e2>"], "h": {"id": "C1522417", "name": "C1522417#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413865", "name": "C1413865#ent", "pos": [20, 21]}}
{"token": ["The", "hormonally", "active", "form", "vitamin", "D(3),1alpha,25-dihydroxyvitamin", "D(3)", "1,25(OH)(2)D(3", ")", "]", ",", "is", "synthesized", "in", "the", "kidney", "through", "a", "tightly", "regulated", "reaction", "catalyzed", "by", "C1522417#ent", "<e1>", "1alpha-hydroxylase", ")", ",", "the", "product", "of", "the", "C1413865#ent", "<e2>"], "h": {"id": "C1522417", "name": "C1522417#ent", "pos": [23, 24]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413865", "name": "C1413865#ent", "pos": [32, 33]}}
{"token": ["Werner", "syndrome", "C1421487#ent", "<e1>", ")", "is", "characterized", "by", "the", "early", "onset", "senescent", "phenotypes", "including", "C3665365#ent", "<e2>", "although", "the", "underlying", "molecular", "mechanism", "atherosclerosis", "has", "not", "been", "fully", "understood", "yet", "."], "h": {"id": "C1421487", "name": "C1421487#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3665365", "name": "C3665365#ent", "pos": [14, 15]}}
{"token": ["C0812443#ent", "<e1>", "(", "TPO", ")", "is", "a", "growth", "and", "C1367656#ent", "<e2>", "megakaryocytes", "and", "platelets", "."], "h": {"id": "C0812443", "name": "C0812443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367656", "name": "C1367656#ent", "pos": [9, 10]}}
{"token": ["C0812443#ent", "<e1>", "(", "TPO", ")", "is", "a", "recently", "cloned", "growth", "and", "C1367656#ent", "<e2>", "in", "megakaryocytopoiesis", "."], "h": {"id": "C0812443", "name": "C0812443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367656", "name": "C1367656#ent", "pos": [11, 12]}}
{"token": ["We", "also", "show", "that", "C3539807#ent", "<e1>", "is", "a", "C0072402#ent", "<e2>", "is", "recruited", "by", "TRADD", "to", "TNFR1", "in", "a", "TNF-dependent", "process", "."], "h": {"id": "C3539807", "name": "C3539807#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [8, 9]}}
{"token": ["Patients", "with", "C0022521#ent", "<e1>", "potentially", "develop", "recurrent", "sinotrachrobronchitis", "bronchiectasis", ",", "C0271453#ent", "<e2>", "hydrocephalus", ",", "and", "male", "infertility", "."], "h": {"id": "C0022521", "name": "C0022521#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0271453", "name": "C0271453#ent", "pos": [10, 11]}}
{"token": ["Analysis", "of", "C4255177#ent", "<e1>", "the", "induction", "of", "C1565830#ent", "<e2>", "(", "Cox-1", ")", "by", "TGF-beta", "1", "the", "induction", "of", "Cox-2", "by", "IL-1", "beta", "TNF-alpha", "."], "h": {"id": "C4255177", "name": "C4255177#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [7, 8]}}
{"token": ["This", "study", "compared", "the", "results", "of", "reflex", "modification", "(RM)--an", "objective", "technique", "for", "assessing", "brainstem", "sensorineural", "processing", "--", "with", "those", "of", "auditory", "brainstem", "response", "C1412101#ent", "<e1>", ")", "for", "a", "group", "of", "high-risk", "infants", "comparable", "C0000782#ent", "<e2>"], "h": {"id": "C1412101", "name": "C1412101#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0000782", "name": "C0000782#ent", "pos": [33, 34]}}
{"token": ["She", "exhibited", "C0035326#ent", "<e1>", "confluent", "necrotizing", "retinitis", ",", "mainly", "peripheral", ",", "and", "C0022073#ent", "<e2>", "."], "h": {"id": "C0035326", "name": "C0035326#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022073", "name": "C0022073#ent", "pos": [12, 13]}}
{"token": ["We", "suggested", "that", "the", "mechanisms", "of", "the", "inhibitory", "effect", "of", "HAs", "on", "C0003850#ent", "<e1>", "could", "be", "via", "inhibiting", "the", "proliferation", "of", "C1539322#ent", "<e2>", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [21, 22]}}
{"token": ["C0003850#ent", "<e1>", "is", "a", "complex", "disease", "which", "smooth", "muscle", "cells", "C1539322#ent", "<e2>", ")", "play", "a", "fundamental", "role", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [10, 11]}}
{"token": ["DNA", "replication", "at", "specific", "sites", "in", "both", "simple", "and", "complex", "C0017428#ent", "<e1>", ",", "but", "origins", "in", "complex", "C0017428#ent", "<e1>", "may", "include", "C3273474#ent", "<e1>", "well", "as", "DNA", "sequence"], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273474", "name": "C3273474#ent", "pos": [21, 22]}}
{"token": ["The", "present", "work", "investigates", "the", "incorporation", "of", "[1", "-", "14C]sodium", "C0000979#ent", "<e1>", "in", "alkylating", "agent", "sensitive", "(", "C0175702#ent", "<e2>", ")", "and", "resistant", "(", "WR", ")", "Walker", "256", "carcinosarcoma", "cells"], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [17, 18]}}
{"token": ["C0282102#ent", "<e1>", "a", "human", "gene", "defect", "by", "punctate", "foci", "epiphyseal", "calcification", "cataracts", ",", "C0020757#ent", "<e2>", ",", "and", "systematized", "atrophoderma", "."], "h": {"id": "C0282102", "name": "C0282102#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020757", "name": "C0020757#ent", "pos": [13, 14]}}
{"token": ["Conradi-H\u00fcnermann-Happle", "syndrome", "or", "C0282102#ent", "<e1>", "is", "a", "rare", "genetic", "disorder", "by", "skeletal", "dysplasia", "stippled", "epiphyses", "cataracts", ",", "C0020757#ent", "<e2>", "atrophic", "residua", "in", "a", "mosaic", "pattern", "."], "h": {"id": "C0282102", "name": "C0282102#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0020757", "name": "C0020757#ent", "pos": [17, 18]}}
{"token": ["Additionally", ",", "C0282102#ent", "<e1>", "patients", "may", "have", "asymmetric", "rhizomesomelia", ",", "sectorial", "cataracts", "patchy", "alopecia", "C0020757#ent", "<e2>", "and", "atrophoderma", "."], "h": {"id": "C0282102", "name": "C0282102#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0020757", "name": "C0020757#ent", "pos": [14, 15]}}
{"token": ["C0059735#ent", "<e1>", "aryl", "hydrocarbon", "hydroxylase", "activities", ",", "catalytic", "functions", "scup", "C0525529#ent", "<e2>", ",", "were", "induced", "in", "parallel", "with", "P450", "content", "."], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0525529", "name": "C0525529#ent", "pos": [10, 11]}}
{"token": ["S.", "epidermidis-induced", "TNF-alpha", "was", "inhibited", "by", "IL-18BP", "and", "C1704264#ent", "<e1>", ",", "but", "not", "anti-IL-12", "Ab", ",", "whereas", "C1705592#ent", "<e2>", "production", "was", "unaffected", "by", "any", "of", "the", "specific", "cytokine", "blocking", "agents", "."], "h": {"id": "C1704264", "name": "C1704264#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [17, 18]}}
{"token": ["Heat", "stress", "early", ",", "simultaneous", "release", "of", "anti-inflammatory", "cytokines", "chemokines", "(", "IL-10", ",", "C1704264#ent", "<e1>", ",", "sTNFr", "I", "and", "II", ",", "and", "C1705592#ent", "<e2>", ")", "."], "h": {"id": "C1704264", "name": "C1704264#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [22, 23]}}
{"token": ["Maleless", "protein", "(", "MLE", ")", "is", "highly", "C1512488#ent", "<e1>", "to", "human", "C1413965#ent", "<e2>", "and", "the", "bovine", "counterpart", "of", "RNA", "helicase", "A", "nuclear", "helicase", "II"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413965", "name": "C1413965#ent", "pos": [11, 12]}}
{"token": ["Moc2", "is", "highly", "C1512488#ent", "<e1>", "to", "the", "C1413965#ent", "<e2>", "DED1", "of", "Saccharomyces", "cerevisiae", "58", "%", "identity", ")", "and", "PL10", "of", "mouse", "(", "50", "%", "identity", ")", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413965", "name": "C1413965#ent", "pos": [7, 8]}}
{"token": ["We", "characterize", "a", "conserved", "C2917660#ent", "<e1>", "substitution", "between", "C1333897#ent", "<e2>", "and", "HIF-2alpha", "that", "contributes", "to", "the", "intrinsically", "higher", "FIH-1-mediated", "asparaginyl", "hydroxylation", "of", "C1333897#ent", "<e2>", "and", ",", "hence", ",", "lower", "C1333897#ent", "<e2>", "activity", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [8, 9]}}
{"token": ["In", "this", "work", ",", "we", "demonstrate", "that", "SSAT1", ",", "which", "shares", "46", "%", "C2917660#ent", "<e1>", "with", "SSAT2", ",", "also", "binds", "to", "C1333897#ent", "<e2>", "and", "promotes", "its", "ubiquitination/degradation", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [21, 22]}}
{"token": ["The", "C1254351#ent", "<e1>", "contains", "1.5", "or", "3", "%", "of", "C0003166#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003166", "name": "C0003166#ent", "pos": [9, 10]}}
{"token": ["It", "was", "difficult", "to", "completely", "eliminate", "the", "C1254351#ent", "<e1>", "by", "washing", "with", "soap", "and", "C0003166#ent", "<e2>", "could", "even", "be", "detected", "on", "non-treated", "areas", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003166", "name": "C0003166#ent", "pos": [14, 15]}}
{"token": ["The", "recent", "availability", "of", "C0058038#ent", "<e1>", ",", "a", "full", "D1", "C2987634#ent", "<e2>", ",", "prompted", "us", "to", "reevaluate", "the", "role", "of", "D1", "and", "D2", "receptors", "the", "regulation", "of", "blink", "rate"], "h": {"id": "C0058038", "name": "C0058038#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}}
{"token": ["Also", ",", "C0058038#ent", "<e1>", "was", "the", "first", "dopamine", "D(1)", "receptor", "C2987634#ent", "<e2>", "that", "had", "potent", "antiparkinsonian", "activity", "a", "primate", "model", "Parkinson's", "disease"], "h": {"id": "C0058038", "name": "C0058038#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}}
{"token": ["C0058038#ent", "<e1>", "(", "DHX", ")", ",", "a", "potent", "full", "C2987634#ent", "<e2>", "with", "dramatic", "antiparkinsonian", "actions", ",", "displayed", "intrinsic", "activity", "similar", "to", "dopamine", "in", "all", "three", "cell", "lines"], "h": {"id": "C0058038", "name": "C0058038#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [9, 10]}}
{"token": ["C0038463#ent", "<e1>", "unresponsive", "to", "C0022322#ent", "<e2>", "oral", "albendazole", ",", "was", "controlled", "by", "subcutaneous", "administration", "a", "veterinary", "preparation", "ivermectin", "."], "h": {"id": "C0038463", "name": "C0038463#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0022322", "name": "C0022322#ent", "pos": [4, 5]}}
{"token": ["Membrane", "immunofluorescence", "analysis", "that", "all", "the", "clones", "expressed", "human", "and", "mouse", "class", "1", "MHC", "antigens", "the", "mouse", "T", "cell", "antigens", "Thy-1", "and", "C1335285#ent", "<e1>", ",", "but", "were", "devoid", "of", "human", "OKT3", ",", "C1413244#ent", "<e2>", "and", "mouse", "Lyt-2", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1413244", "name": "C1413244#ent", "pos": [32, 33]}}
{"token": ["The", "author", "then", "defines", "and", "describes", "C0155145#ent", "<e1>", "toxic", "follicular", "conjunctivitis", "(", "C0026393#ent", "<e2>", "and", "folliculosis", "."], "h": {"id": "C0155145", "name": "C0155145#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026393", "name": "C0026393#ent", "pos": [12, 13]}}
{"token": ["The", "strength", "and", "oxidative", "capacity", "skeletal", "muscle", "major", "determinants", "of", "physical", "performance", "whether", "in", "C0733440#ent", "<e1>", "athletes", "or", "in", "patients", "with", "C0018802#ent", "<e2>", "other", "circulatory", "disorders"], "h": {"id": "C0733440", "name": "C0733440#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["A", "similar", "strong", "immunogold", "signal", "was", "obtained", "when", "labelling", "for", "C1706178#ent", "<e1>", ",", "a", "specific", "C0014442#ent", "<e2>", "of", "the", "sarcoplasmic", "reticulum", "membrane", "in", "regions", "of", "typical", "occurrence", "of", "the", "sarcoplasmic", "reticulum", "in", "tubular", "aggregates", "."], "h": {"id": "C1706178", "name": "C1706178#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["The", "complications", "resulting", "in", "the", "most", "severe", "illness", "were", "acute", "splenic", "sequestration", ",", "C0025295#ent", "<e1>", "and", "some", "episodes", "of", "C0542035#ent", "<e2>", "in", "very", "low", "haemoglobin", "concentrations"], "h": {"id": "C0025295", "name": "C0025295#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0542035", "name": "C0542035#ent", "pos": [19, 20]}}
{"token": ["The", "C0852949#ent", "<e1>", "tends", "to", "progress", "with", "age", ",", "and", "C0020538#ent", "<e2>", "common", "in", "teenagers", "and", "beyond", "."], "h": {"id": "C0852949", "name": "C0852949#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [10, 11]}}
{"token": ["A", "C3889265#ent", "<e1>", "of", "6.8", "was", "obtained", "using", "C0078743#ent", "<e2>", "as", "a", "contractile", "agent", "this", "value", "differed", "significantly", "from", "7.4", ",", "the", "value", "obtained", "for", "5-HT", "and", "5-methoxytryptamine.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C3889265", "name": "C3889265#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0078743", "name": "C0078743#ent", "pos": [8, 9]}}
{"token": ["C3539946#ent", "<e1>", "1046", "are", "common", "to", "both", "C1425358#ent", "<e2>", "variants", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1425358", "name": "C1425358#ent", "pos": [7, 8]}}
{"token": ["The", "regulatory", "subunit", "the", "C0010531#ent", "<e1>", "Rt", ")", "serves", "as", "a", "substrate", "for", "the", "C1335408#ent", "<e2>", "catalyzed", "by", "cGMP-dependent", "protein", "kinase", "Km", "=", "2.2", "microM", ")", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335408", "name": "C1335408#ent", "pos": [14, 15]}}
{"token": ["Partially", "purified", "rabbit", "skeletal", "muscle", "phosphorylase", "phosphatase", "EC", "3.1.3.17", ";", "phosphoprotein", "phosphohydrolase", "was", "inactivated", "when", "it", "was", "incubated", "with", "exogenous", "C0010531#ent", "<e1>", "EC", "2.7.1.37", ";", "ATP", ":", "C1335408#ent", "<e2>", ",", "cyclic", "AMP", "and", "ATP-Mg", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1335408", "name": "C1335408#ent", "pos": [27, 28]}}
{"token": ["The", "authors", "have", "recently", "demonstrated", "that", "one", "consequence", "is", "the", "reduction", "in", "red", "cell", "membrane", "protein", "methylation", "levels", ",", "caused", "by", "a", "rise", "of", "intracellular", "C3887563#ent", "<e1>", ",", "a", "potent", "inhibitor", "of", "C0025831#ent", "<e2>", "."], "h": {"id": "C3887563", "name": "C3887563#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0025831", "name": "C0025831#ent", "pos": [32, 33]}}
{"token": ["Two", "structures", "with", "bound", "S-adenosyl-L-methionine", "and", "C3887563#ent", "<e1>", "confirm", "that", "the", "cofactor", "binding", "mode", "highly", "similar", "to", "other", "C0025831#ent", "<e2>"], "h": {"id": "C3887563", "name": "C3887563#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025831", "name": "C0025831#ent", "pos": [18, 19]}}
{"token": ["KDN", "was", "transferred", "to", "all", "four", "Gal", "residues", "C0052505#ent", "<e1>", "by", "this", "C0014442#ent", "<e2>", "."], "h": {"id": "C0052505", "name": "C0052505#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["Since", "the", "1970s", "tetrahydropapaveroline", "(", "C1705396#ent", "<e1>", ")", "and", "other", "C0259969#ent", "<e2>", "been", "implicated", "in", "the", "etiology", "of", "alcoholism", "."], "h": {"id": "C1705396", "name": "C1705396#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0259969", "name": "C0259969#ent", "pos": [10, 11]}}
{"token": ["Three", "had", "C0038539#ent", "<e1>", "one", "had", "a", "C0038539#ent", "<e1>", "an", "anterior", "1/3", "superior", "sagittal", "sinus", "thrombosis", "multiple", "brain", "abscesses"], "h": {"id": "C0038539", "name": "C0038539#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038539", "name": "C0038539#ent", "pos": [2, 3]}}
{"token": ["Sometribove", "did", "not", "affect", "the", "incidence", "of", "C0022638#ent", "<e1>", ",", "milk", "fever", "tetany", ",", "or", "C1535939#ent", "<e2>", "."], "h": {"id": "C0022638", "name": "C0022638#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [15, 16]}}
{"token": ["The", "alpha", "and", "beta", "subunits", "catalytic", "sites", "cGMP", "hydrolysis", ",", "whereas", "the", "C1415155#ent", "<e1>", "as", "a", "protein", "inhibitor", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C1415155", "name": "C1415155#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [19, 20]}}
{"token": ["The", "high", "affinity", "of", "C0018312#ent", "<e1>", "to", "C1620185#ent", "<e2>", "and", "the", "distinct", "selectivity", "of", "this", "P450", "isozyme", "C0018312#ent", "<e1>", "confirms", "the", "in", "vitro", "C0018312#ent", "<e1>", "N-hydroxylation", "to", "be", "a", "suitable", "metabolic", "marker", "C1620185#ent", "<e2>", "in", "biotransformation", "studies", "."], "h": {"id": "C0018312", "name": "C0018312#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [7, 8]}}
{"token": ["MZ-J-7-138", "or", "in", "combination", "with", "C0246415#ent", "<e1>", "significantly", "reduced", "protein", "levels", "K-Ras", ",", "C1565860#ent", "<e2>", ",", "and", "pAkt", "by", "56", "-", "63", "%", "."], "h": {"id": "C0246415", "name": "C0246415#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [13, 14]}}
{"token": ["New", "agents", "as", "C0048504#ent", "<e1>", ",", "hydroxocobalamin", "and", "the", "heavy", "metal", "chelating", "agents", "DMSA", "and", "C0041738#ent", "<e2>", "were", "infrequently", "held", "."], "h": {"id": "C0048504", "name": "C0048504#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041738", "name": "C0041738#ent", "pos": [15, 16]}}
{"token": ["Since", "gamma-amino-butyric", "acid", "GABA", ")", "might", "act", "as", "an", "C0243046#ent", "<e1>", "early", "stages", "development", ",", "we", "here", "investigated", "if", "C1414919#ent", "<e2>", "inhibit", "PMNs", "in", "neonates", "."], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414919", "name": "C1414919#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "the", "frequency", "of", "common", "symptoms", "and", "complications", "amoung", "adult", "patients", "with", "either", "non-insulin-dependent", "or", "C1852092#ent", "<e1>", "to", "examine", "associations", "of", "these", "problems", "with", "C0268790#ent", "<e2>", "risk", "factors"], "h": {"id": "C1852092", "name": "C1852092#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [25, 26]}}
{"token": ["The", "more", "common", "K15-P", "C0002085#ent", "<e1>", "has", "been", "shown", "to", "activate", "the", "mitogen-activated", "protein", "kinases", "Erk2", "and", "C1705632#ent", "<e2>", "and", "the", "nuclear", "factor", "kappaB", "NF-kappaB", ")", "pathway", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705632", "name": "C1705632#ent", "pos": [17, 18]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "evaluate", "the", "prevalence", "of", "C0026267#ent", "<e1>", "a", "large", "cohort", "of", "UK", "patients", "with", "C2020284#ent", "<e2>", "whom", "the", "clinical", "diagnosis", "been", "confirmed", "by", "molecular", "genetic", "analysis"], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C2020284", "name": "C2020284#ent", "pos": [20, 21]}}
{"token": ["The", "C1425349#ent", "<e1>", "its", "effects", "through", "C1332660#ent", "<e2>", ",", "an", "endoplasmic", "reticulum", "(ER)-localized", "protein", "controls", "Ca(2+)", "efflux", "."], "h": {"id": "C1425349", "name": "C1425349#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332660", "name": "C1332660#ent", "pos": [6, 7]}}
{"token": ["Well-designed", "studies", "suggest", "that", "C0002575#ent", "<e1>", "is", "not", "an", "appropriate", "first-line", "medication", "C0004096#ent", "<e2>"], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [12, 13]}}
{"token": ["The", "effectiveness", "of", "epinephrine", "was", "compared", "to", "that", "of", "a", "combination", "of", "epinephrine", "and", "C0002575#ent", "<e1>", "in", "the", "initial", "treatment", "of", "C0004096#ent", "<e2>"], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}}
{"token": ["In", "humans", ",", "mutations", "in", "this", "C0079429#ent", "<e1>", "may", "be", "responsible", "for", "a", "subset", "of", "patients", "with", "C0043459#ent", "<e2>", "a", "lethal", "inborn", "error", "peroxisome", "assembly"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [17, 18]}}
{"token": ["There", "was", "no", "significant", "in", "the", "sensitivity", "of", "the", "test", "at", "different", "sites", "in", "C0014060#ent", "<e1>", "and", "no", "correlation", "between", "a", "positive", "test", "skin", ",", "C0264511#ent", "<e2>", "or", "conjunctiva", "and", "clinical", "mucosal", "involvement", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0264511", "name": "C0264511#ent", "pos": [25, 26]}}
{"token": ["The", "C3541369#ent", "<e1>", "choline", ",", "betaine", "and", "N", ",", "C0005304#ent", "<e2>", ",", "reside", "along", "a", "biosynthetic", "pathway", "to", "the", "synthesis", "of", "membrane", "phospholipids", "neurotransmitters", "with", "various", "biological", "functions"], "h": {"id": "C3541369", "name": "C3541369#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0005304", "name": "C0005304#ent", "pos": [9, 10]}}
{"token": ["If", "a", "patient", "with", "C0041327#ent", "<e1>", "complains", "of", "C0019825#ent", "<e2>", "then", "concomitant", "tuberculous", "laryngitis", "the", "first", "differential", "diagnostic", "consideration", "."], "h": {"id": "C0041327", "name": "C0041327#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019825", "name": "C0019825#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "some", "C0001637#ent", "<e1>", "phenobarbitone", ",", "diazepam", "and", "phenytoin", "on", "C0751495#ent", "<e2>", "produced", "by", "propranolol", "were", "investigated", "in", "mice", "."], "h": {"id": "C0001637", "name": "C0001637#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [12, 13]}}
{"token": ["A", "new", "immunosuppressant", ",", "FK", "506", ",", "has", "replaced", "C0010592#ent", "<e1>", "to", "facilitate", "organ", "transplantation", "but", "unwanted", "effects", ",", "including", "C0235025#ent", "<e2>", "have", "been", "documented", "in", "some", "patients", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [20, 21]}}
{"token": ["If", "non-treated", "or", "misdiagnosed", ",", "C0403416#ent", "<e1>", "clinically", "defined", "as", "rapidly", "C0017658#ent", "<e2>", "RPGN", ")", ",", "may", "lead", "to", "end-stage", "renal", "failure", "ESRD", ")", "within", "a", "short", "time"], "h": {"id": "C0403416", "name": "C0403416#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [11, 12]}}
{"token": ["C0403416#ent", "<e1>", "the", "most", "severe", "form", "of", "C0017658#ent", "<e2>", "and", ",", "if", "untreated", ",", "patients", "will", "develop", "renal", "failure", "days", "or", "weeks", "of", "diagnosis", "."], "h": {"id": "C0403416", "name": "C0403416#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [7, 8]}}
{"token": ["C0403416#ent", "<e1>", "a", "rapidly", "progressive", "form", "of", "C0017658#ent", "<e2>", ",", "but", "treatment", "remains", "non-specific", "."], "h": {"id": "C0403416", "name": "C0403416#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [7, 8]}}
{"token": ["Three", "cases", "were", "complicated", "by", "C0019360#ent", "<e1>", "one", "by", "hyperthyroidism", ",", "and", "one", "by", "C0677607#ent", "<e2>"], "h": {"id": "C0019360", "name": "C0019360#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [14, 15]}}
{"token": ["Similar", "residues", "are", "essential", "for", "di-metal-mediated", "catalysis", "in", "mammalian", "C1382029#ent", "<e1>", "a", "family", "of", "DNA", "polymerases", "C0035673#ent", "<e2>", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035673", "name": "C0035673#ent", "pos": [16, 17]}}
{"token": ["C1956257#ent", "<e1>", "occurring", "as", "part", "of", "a", "named", "C1848862#ent", "<e2>", "or", "without", "associated", "multiple", "congenital", "abnormalities", "rare", "."], "h": {"id": "C1956257", "name": "C1956257#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [8, 9]}}
{"token": ["In", "Lc/+", "mutants", ",", "the", "effects", "of", "C0006462#ent", "<e1>", "were", "attenuated", ",", "but", "higher", "C0041260#ent", "<e2>", "and", "indoleamine", "levels", ",", "suggest", "a", "storage", "of", "serotonin", "in", "a", "non-releasable", "compartment", "."], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041260", "name": "C0041260#ent", "pos": [14, 15]}}
{"token": ["Only", "a", "few", "yeast", "strains", "pectin-degrading", "enzymes", "as", "pectin", "esterases", "C0035681#ent", "<e1>", "(", "hydrolases", "and", "C0024188#ent", "<e2>", ")", "."], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024188", "name": "C0024188#ent", "pos": [15, 16]}}
{"token": ["To", "assess", "the", "epidemiology", "and", "treatment", "of", "storage", "symptoms", "of", "C0878773#ent", "<e1>", "OAB", ")", "and", "voiding", "symptoms", "of", "bladder", "outlet", "obstruction", "C3890229#ent", "<e2>", ")", "because", "of", "benign", "prostatic", "hyperplasia", "UK", "general", "practice"], "h": {"id": "C0878773", "name": "C0878773#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3890229", "name": "C3890229#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "the", "muscarinic", "agonist", "carbachol", "strongly", "stimulated", "C3810542#ent", "<e1>", "but", "failed", "to", "activate", "C0388638#ent", "<e2>", "."], "h": {"id": "C3810542", "name": "C3810542#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [15, 16]}}
{"token": ["TrpL", "channels", "also", "activated", "in", "excised", "inside-out", "patches", "by", "cytoplasmic", "application", "mammalian", "PLC-b2", ",", "bacterial", "C3810542#ent", "<e1>", "and", "PC-PLC", ",", "but", "not", "by", "phospholipase", "D", "C0388638#ent", "<e2>", ")", "."], "h": {"id": "C3810542", "name": "C3810542#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [25, 26]}}
{"token": ["C0020538#ent", "<e1>", "drank", "more", "C0001975#ent", "<e2>", "than", "did", "hypotensive", "animals", "over", "a", "wide", "range", "of", "concentrations", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [4, 5]}}
{"token": ["As", "many", "as", "20", "to", "25", "percent", "of", "patients", "with", "C0020538#ent", "<e1>", "normotensive", "with", "dietary", "modifications", "exercise", "and", "C0001975#ent", "<e2>"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [18, 19]}}
{"token": ["Lamotrigine", ",", "a", "new", "C0003286#ent", "<e1>", ",", "is", "effective", "in", "trigeminal", "neuralgia", "C3276706#ent", "<e2>", "and", "post-stroke", "pain", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3276706", "name": "C3276706#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "the", "reciprocal", "response", "of", "C1335272#ent", "<e1>", "versus", "MAG", "C1417679#ent", "<e2>", "to", "RA", "demonstrates", "that", "these", "two", "C1417679#ent", "<e2>", "utilize", "different", "regulatory", "mechanisms"], "h": {"id": "C1335272", "name": "C1335272#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["However", ",", "the", "alpha8-mediated", "cell", "survival", "was", "blocked", "by", "C0251991#ent", "<e1>", ",", "a", "PI3", "kinase", "inhibitor", "but", "not", "by", "C0075193#ent", "<e2>", ",", "a", "PKC", "inhibitor", ",", "or", "PD98059", ",", "a", "MAPK", "kinase", "inhibitor"], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [19, 20]}}
{"token": ["Either", "U73122", "or", "G\u00f66976", "did", "not", "inhibit", "ERK1/2", "phosphorylation", "induced", "by", "ATP/UTP", ",", "while", "it", "was", "inhibited", "by", "C0251991#ent", "<e1>", "(", "or", "wortmannin", ")", "and", "by", "C0075193#ent", "<e2>", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [26, 27]}}
{"token": ["Two", "general", "solid-phase", "methods", "the", "synthesis", "of", "a", "new", "class", "of", "C0058171#ent", "<e1>", "(", "DKPs", ")", "containing", "the", "trans-4-hydroxy-L-proline", "amino", "acid", "residue", "C0813171#ent", "<e2>", ")", "have", "been", "developed", "."], "h": {"id": "C0058171", "name": "C0058171#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0813171", "name": "C0813171#ent", "pos": [22, 23]}}
{"token": ["Abundant", "pyrolysis", "products", "of", "the", "fresh", "skin", "tissue", "including", "C0058171#ent", "<e1>", "of", "Pro-Gly", ",", "Pro-Ala", ",", "Pro-Val", ",", "Pro-Pro", "and", "C0813171#ent", "<e2>", ",", "were", "readily", "assigned", "to", "specific", "amino", "acid", "dipeptide", "moieties", "."], "h": {"id": "C0058171", "name": "C0058171#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0813171", "name": "C0813171#ent", "pos": [20, 21]}}
{"token": ["To", "obtain", "a", "derivative", "which", "is", "stable", "in", "vivo", "the", "C0025543#ent", "<e1>", "was", "modified", "with", "activated", "C0032483#ent", "<e2>"], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "increased", "DNA", "binding", "of", "C2986464#ent", "<e1>", "in", "response", "to", "TNF-alpha", ",", "an", "C2987634#ent", "<e2>", "of", "NF-kappaB", "signaling", "was", "seen", "in", "differentiated", "but", "not", "undifferentiated", "mouse", "ES", "cells"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}}
{"token": ["However", ",", "a", "combination", "of", "polyT", "ODN", "plus", "the", "TLR8", "agonist", "activated", "C2986464#ent", "<e1>", ",", "whereas", "polyT", "ODN", "plus", "the", "TLR7", "C2987634#ent", "<e2>", "did", "not", "activate", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [21, 22]}}
{"token": ["Pathological", "skin", "manifestations", "in", "autoimmune", "endocrinopathies", "C0033103#ent", "<e1>", "Graves'", "disease", "diabetic", "dermopathy", "necrobiosis", "lipoidica", "type", "I", "autoimmune", "diabetes", "mellitus", "candidiasis", ",", "ectodermal", "dysplasia", "vitiligo", "and", "C0002170#ent", "<e2>", "APECED", "and", "uniform", "hyperpigmentation", "of", "the", "skin", "in", "Addison's", "disease"], "h": {"id": "C0033103", "name": "C0033103#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [25, 26]}}
{"token": ["Furthermore", "GnRH", "induces", "activation", "of", "the", "c-Jun", "N-terminal", "kinase/activator", "protein-1", "JNK/AP-1", ")", "pathway", "independent", "of", "the", "known", "C0162508#ent", "<e1>", "activators", ",", "protein", "kinase", "PKC", ")", "or", "mitogen", "activated", "protein", "kinase", "C1434639#ent", "<e2>", ")", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1434639", "name": "C1434639#ent", "pos": [30, 31]}}
{"token": ["In", "addition", ",", "manganese", "induces", "phosphorylation", "of", "C0162508#ent", "<e1>", "at", "Ser63", "and", "Ser73", "and", "SEK1/MKK4", "(", "C1434639#ent", "<e2>", "at", "Thr258", "and", "tyrosine", "phosphorylation", "several", "proteins", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1434639", "name": "C1434639#ent", "pos": [16, 17]}}
{"token": ["High-purity", "factor", "IX", "concentrates", "are", "available", "and", "are", "the", "treatment", "of", "choice", "for", "patients", "with", "C0008533#ent", "<e1>", "the", "absence", "of", "a", "source", "of", "C2826076#ent", "<e2>"], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C2826076", "name": "C2826076#ent", "pos": [23, 24]}}
{"token": ["The", "majority", "of", "these", "tumors", "displays", "aberrant", "activation", "of", "the", "SONIC", "HEDGEHOG", "(SHH)/PATCHED", "pathway", ",", "triggered", "by", "mutations", "in", "the", "C1826732#ent", "<e1>", "tumor", "suppressor", "gene", "which", "encodes", "a", "transmembrane", "receptor", "C0672708#ent", "<e2>", "."], "h": {"id": "C1826732", "name": "C1826732#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0672708", "name": "C0672708#ent", "pos": [30, 31]}}
{"token": ["We", "also", "identified", "several", "important", "C0633225#ent", "<e1>", "i.e.", ",", "catalase", ",", "superoxide", "dismutase", "glutathione", "transferase", "paraoxonase", ",", "heat", "shock", "protein", "27", "C0072354#ent", "<e2>"], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0072354", "name": "C0072354#ent", "pos": [21, 22]}}
{"token": ["It", "has", "been", "shown", "in", "vitro", "human", "acidic", "gastric", "juice", "nitrosomorpholine", "(", "C1709138#ent", "<e1>", ")", "formation", "from", "small", "doses", "precursors", "(", "sodium", "nitrite", "C0026560#ent", "<e2>", ")", "with", "a", "significant", "difference", "relative", "to", "the", "control", "."], "h": {"id": "C1709138", "name": "C1709138#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026560", "name": "C0026560#ent", "pos": [23, 24]}}
{"token": ["mRNA", "data", "from", "C1706333#ent", "<e1>", "myocardium", "in", "intervention", "hearts", "were", "normalized", "to", "those", "from", "C1706333#ent", "<e1>", "tissue", "in", "the", "control", "heart", "LADc", ")", "and", "with", "C1955822#ent", "<e1>", "values", "in", "the", "same", "intervention", "hearts", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1955822", "name": "C1955822#ent", "pos": [25, 26]}}
{"token": ["Synthesis", "of", "Ap4A", "by", "phenylalanyl-tRNA", "synthetases", "the", "three", "compartments", "of", "a", "plant", "cell", "by", "other", "C3540017#ent", "<e1>", "such", "as", "C0057682#ent", "<e2>", "discussed", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0057682", "name": "C0057682#ent", "pos": [19, 20]}}
{"token": ["We", "report", "the", "case", "of", "factitiously", "induced", "C0002874#ent", "<e1>", "the", "ingestion", "of", "busulfan", ",", "a", "bifunctional", "C0282532#ent", "<e2>", "in", "the", "treatment", "of", "chronic", "myelogenous", "leukemia"], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0282532", "name": "C0282532#ent", "pos": [16, 17]}}
{"token": ["Despite", "neuroleptic", "anaesthesia", "C0010977#ent", "<e1>", "pretreatment", ",", "the", "patient", "experienced", "C0024591#ent", "<e2>"], "h": {"id": "C0010977", "name": "C0010977#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0024591", "name": "C0024591#ent", "pos": [10, 11]}}
{"token": ["C1833640#ent", "<e1>", "inhibited", "thiazolidinedione-induced", "transactivation", "by", "C1335238#ent", "<e2>", "in", "a", "dominant", "negative", "manner", "."], "h": {"id": "C1833640", "name": "C1833640#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [6, 7]}}
{"token": ["By", "real-time", "RT-PCR", "we", "observed", "that", "tumours", "negative", "for", "the", "C1833640#ent", "<e1>", "rearrangement", "expressed", "lower", "levels", "of", "C1335238#ent", "<e2>", "mRNA", "than", "the", "NT", "."], "h": {"id": "C1833640", "name": "C1833640#ent", "pos": [10, 11]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [17, 18]}}
{"token": ["Two", "different", "Smad", "binding", "regions", "localized", ",", "a", "distal", "binding", "region", "for", "C1414988#ent", "<e1>", "containing", "two", "C0251107#ent", "<e2>", "motifs", "and", "proximal", "AGNC", "binding", "sites", "for", "Smad4", ",", "the", "latter", "being", "conserved", "in", "other", "transforming", "growth", "factor-beta-responsive", "elements"], "h": {"id": "C1414988", "name": "C1414988#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0251107", "name": "C0251107#ent", "pos": [16, 17]}}
{"token": ["In", "C1416467#ent", "<e1>", ",", "low", "calorie", "intake", "mitigate", "the", "effects", "of", "weight", "loss", "C1847987#ent", "<e2>", "."], "h": {"id": "C1416467", "name": "C1416467#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1847987", "name": "C1847987#ent", "pos": [13, 14]}}
{"token": ["C0055082#ent", "<e1>", "in", "combination", "with", "C1412244#ent", "<e2>", "should", "be", "useful", "for", "treating", "patients", "with", "tumors", "."], "h": {"id": "C0055082", "name": "C0055082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412244", "name": "C1412244#ent", "pos": [5, 6]}}
{"token": ["C0055082#ent", "<e1>", "changed", "the", "distribution", "of", "C1412244#ent", "<e2>", "from", "cytoplasmic", "vesicles", "nucleoplasm", "in", "K562", "cells", "inhibiting", "the", "acidification", "of", "cytoplasmic", "organelles"], "h": {"id": "C0055082", "name": "C0055082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412244", "name": "C1412244#ent", "pos": [6, 7]}}
{"token": ["14", ")", "led", "us", "to", "consider", "the", "human", "homologue", "as", "a", "good", "candidate", "for", "the", "C0079429#ent", "<e1>", "that", "is", "defective", "in", "C1848638#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1848638", "name": "C1848638#ent", "pos": [21, 22]}}
{"token": ["In", "humans", ",", "mutations", "in", "the", "C0079429#ent", "<e1>", "encoding", "myosin", "VIIa", "cause", "Usher", "syndrome", "type", "1b", "C1848638#ent", "<e2>", ")", ",", "a", "disease", "characterized", "by", "deafness", "and", "retinitis", "pigmentosa"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1848638", "name": "C1848638#ent", "pos": [16, 17]}}
{"token": ["C1332750#ent", "<e1>", "has", "been", "demonstrated", "to", "bind", "the", "C1420280#ent", "<e2>", "alpha-actinin", "and", "proposed", "to", "modulate", "the", "actin", "cytoskeleton", "however", ",", "specific", "regulatory", "mechanisms", "not", "been", "identified", "."], "h": {"id": "C1332750", "name": "C1332750#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420280", "name": "C1420280#ent", "pos": [8, 9]}}
{"token": ["Cellular", "Fas-associated", "death", "domain-like", "interleukin-1-beta", "converting", "enzyme", "(", "FLICE", ")", "C1415142#ent", "<e1>", "cFLIPs", ")", "are", "endogenous", "caspase", "homologues", "inhibit", "C1418401#ent", "<e2>"], "h": {"id": "C1415142", "name": "C1415142#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [19, 20]}}
{"token": ["Finally", ",", "DHA", "increased", "C1417768#ent", "<e1>", "expression", ",", "Hes-1", "transcription", "a", "Notch", "target", "gene", ",", "and", "enhanced", "C0379528#ent", "<e2>", "."], "h": {"id": "C1417768", "name": "C1417768#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0379528", "name": "C0379528#ent", "pos": [17, 18]}}
{"token": ["Inactivation", "of", "C1417768#ent", "<e1>", "by", "both", "C0379528#ent", "<e2>", "Notch3-specific", "small", "interfering", "RNA", "suppressed", "cell", "proliferation", "induced", "apoptosis", "in", "the", "cell", "lines", "overexpressed", "C1417768#ent", "<e1>", "but", "not", "in", "those", "with", "minimal", "amount", "of", "C1417768#ent", "<e1>", "expression", "."], "h": {"id": "C1417768", "name": "C1417768#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0379528", "name": "C0379528#ent", "pos": [6, 7]}}
{"token": ["Thus", ",", "C0003195#ent", "<e1>", "low", "concentrations", "of", "C0034414#ent", "<e2>", "may", "occur", "through", "differential", "effects", "on", "tissue", "anisotropy"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [7, 8]}}
{"token": ["Several", "C0003195#ent", "<e1>", "such", "as", "procainamide", ",", "C0034414#ent", "<e2>", ",", "propafenone", ",", "encainide", ",", "and", "amiodarone", ",", "are", "transformed", "to", "pharmacologically", "active", "metabolites", ",", "which", "may", "contribute", "to", "their", "antiarrhythmic", "and", "toxic", "effects"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [7, 8]}}
{"token": ["Combinations", "of", "mexiletine", "and", "C0034414#ent", "<e1>", "at", "concentrations", "which", "alone", "had", "little", "electrophysiological", "activity", "C0003195#ent", "<e2>", "than", "that", "seen", "with", "high", "concentrations", "of", "mexiletine", "or", "C0034414#ent", "<e1>", "alone", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [14, 15]}, "relation": "therapeutic_class_of", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [4, 5]}}
{"token": ["Lorcainide", ",", "a", "new", "C0003195#ent", "<e1>", "local", "anesthetic", "or", "membrane-stabilizing", "properties", "similar", "to", "those", "of", "C0034414#ent", "<e2>", ",", "was", "tested", "in", "76", "patients", "with", "diverse", "types", "of", "heart", "disease", "recurrent", "ventricular", "tachycardia", "ventricular", "fibrillation"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [4, 5]}, "relation": "therapeutic_class_of", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [15, 16]}}
{"token": ["Most", "importantly", ",", "the", "SAC", "and", "C1427063#ent", "<e1>", "treatment", "led", "to", "restoration", "of", "C0694872#ent", "<e2>", "expression", "at", "transcription", "and", "protein", "levels"], "h": {"id": "C1427063", "name": "C1427063#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [13, 14]}}
{"token": ["C0021390#ent", "<e1>", "patients", "homozygous", "for", "the", "Stop", "allele", "somewhat", "reduced", "expression", "of", "C1424714#ent", "<e2>", "mRNA", ",", "but", ",", "contrary", "to", "expectation", ",", "expressed", "a", "48", "kDa", "protein", "isoform", "."], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424714", "name": "C1424714#ent", "pos": [12, 13]}}
{"token": ["C1307053#ent", "<e1>", "is", "a", "novel", "C1332794#ent", "<e2>", "has", "been", "shown", "to", "inactivate", "members", "of", "the", "Src", "family", "protein-tyrosine", "kinases", "in", "vitro"], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332794", "name": "C1332794#ent", "pos": [5, 6]}}
{"token": ["An", "increased", "level", "of", "tyrosine-phosphorylated", "C1307053#ent", "<e1>", "suggested", "the", "activation", "of", "this", "C1332794#ent", "<e2>", "response", "to", "thrombin", "and", "its", "potential", "role", "in", "thrombin-induced", "protein-tyrosine", "phosphorylation"], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332794", "name": "C1332794#ent", "pos": [12, 13]}}
{"token": ["C1419437#ent", "<e1>", "generates", "a", "diferric-tyrosyl", "radical", "cofactor", "required", "for", "catalysis", ";", "C1419439#ent", "<e2>", "facilitates", "cofactor", "assembly", "stabilizes", "the", "resulting", "holo-heterodimer", "."], "h": {"id": "C1419437", "name": "C1419437#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419439", "name": "C1419439#ent", "pos": [11, 12]}}
{"token": ["During", "her", "disease", "she", "developed", "C0029089#ent", "<e1>", "to", "tenosynovitis", "of", "the", "superior", "oblique", "muscle", "tendon", "sheath", "C0013080#ent", "<e2>", "."], "h": {"id": "C0029089", "name": "C0029089#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013080", "name": "C0013080#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "demonstrate", "that", "C1539110#ent", "<e1>", "requires", "specific", "DNA", "sequences", "binding", ",", "and", "that", "C1539110#ent", "<e1>", "and", "ArgR", "have", "no", "direct", "role", "in", "C1744318#ent", "<e1>", "P1", "loxP."], "h": {"id": "C1539110", "name": "C1539110#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1744318", "name": "C1744318#ent", "pos": [23, 24]}}
{"token": ["Also", ",", "polycations", "C1414519#ent", "<e1>", "and", "spermine", "reversed", "isoproterenol", "'s", "hyperpolarisation", "effect", ",", "probably", "C0027867#ent", "<e2>", "the", "membrane", "potential", "through", "ionic", "interaction", "neutralising", "the", "action", "of", "isoproterenol", "on", "K+(ATP", ")", "channels", "."], "h": {"id": "C1414519", "name": "C1414519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [14, 15]}}
{"token": ["Abstract", "Glomerulonephritis", "such", "as", "membranous", "nephropathy", "C0017661#ent", "<e1>", "and", "p-antineutrophil", "cytoplasmic", "autoantibody", "crescentic", "glomerulonephritis", "has", "been", "shown", "to", "occur", "in", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [20, 21]}}
{"token": ["C0017661#ent", "<e1>", "with", "proteinuria", "is", "an", "occasional", "complication", "of", "gold", "therapy", "C0003873#ent", "<e2>", "is", "considered", "to", "be", "due", "to", "an", "immune", "hypersensitivity", "reaction"], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}}
{"token": ["In", "turn", ",", "this", "might", "elucidate", "the", "basis", "of", "aberrant", "glycosylation", "reported", "in", "conditions", "such", "as", "C0017661#ent", "<e1>", "cancer", "and", "C0003873#ent", "<e2>"], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [20, 21]}}
{"token": ["As", "soon", "as", "blastocyst", "differentiation", "Em", "and", "C1705312#ent", "<e1>", "has", "been", "accomplished", ",", "insulin", "and", "C1334089#ent", "<e2>", "signaling", "is", "different", "in", "both", "cell", "lineages", "implying", "a", "different", "developmental", "impact", "both", "growth", "factors"], "h": {"id": "C1705312", "name": "C1705312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [15, 16]}}
{"token": ["Many", "physicians", "recommend", "either", "C0525227#ent", "<e1>", "or", "latanoprost", "as", "firstline", "therapy", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0525227", "name": "C0525227#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [11, 12]}}
{"token": ["In-vitro", "data", "indicate", "major", "effects", "of", "the", "genetically", "polymorphic", "C0608437#ent", "<e1>", "CYP2C9", ")", "on", "the", "pharmacokinetics", "of", "C0538927#ent", "<e2>", ",", "a", "nonsteroidal", "anti-inflammatory", "drug", "as", "selective", "cyclooxygenase-2", "inhibitor"], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [9, 10]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [17, 18]}}
{"token": ["In-vitro", "data", "indicate", "major", "effects", "of", "the", "genetically", "polymorphic", "cytochrome", "P450", "enzyme", "2C9", "C0608437#ent", "<e1>", ")", "on", "the", "pharmacokinetics", "of", "C0538927#ent", "<e2>", ",", "a", "nonsteroidal", "anti-inflammatory", "drug", "as", "selective", "cyclooxygenase-2", "inhibitor"], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [13, 14]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [20, 21]}}
{"token": ["We", "performed", "Southern", "blot", "experiments", "and", "among", "the", "eight", "C1335528#ent", "<e1>", "tested", ",", "only", "the", "C0017337#ent", "<e2>", "encoding", "the", "general", "aminopeptidases", "pepC", "and", "pepN", ",", "were", "homologous", "between", "the", "L.", "lactis", "and", "Strep", "."], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["The", "cellular", "immune", "response", "to", "lead", "to", "a", "C2733158#ent", "<e1>", "and", "release", "of", "cytokines", "that", "can", "induce", "C1306759#ent", "<e2>", "and", "fibrosis", "."], "h": {"id": "C2733158", "name": "C2733158#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [17, 18]}}
{"token": ["This", "C0020924#ent", "<e1>", "to", "be", "an", "excellent", "inhibitor", "of", "C0018324#ent", "<e2>", "all", "of", "the", "trypanosomatids", "used", "in", "this", "study", ",", "with", "Ki", "values", "in", "the", "microM", "range", "."], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018324", "name": "C0018324#ent", "pos": [9, 10]}}
{"token": ["By", "screening", "for", "alternative", "oxidation", "pathways", "Saccharomyces", "cerevisiae", "we", "identified", "ERV2", "as", "a", "C0079429#ent", "<e1>", "that", "when", "overexpressed", "can", "restore", "viability", "and", "disulphide", "bond", "formation", "an", "C1705771#ent", "<e2>", "-", "1", "mutant", "strain"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705771", "name": "C1705771#ent", "pos": [26, 27]}}
{"token": ["Whereas", "C0084110#ent", "<e1>", "can", "bind", "to", "a", "region", "around", "the", "left", "inverted", "repeat", "the", "C3273671#ent", "<e2>", "switch", ",", "DaaA", "and", "the", "C0084110#ent", "<e1>", "double", "mutant", "were", "effectively", "unable", "to", "bind", "this", "region", "."], "h": {"id": "C0084110", "name": "C0084110#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273671", "name": "C3273671#ent", "pos": [14, 15]}}
{"token": ["This", "study", "was", "performed", "to", "evaluate", "the", "C1710463#ent", "<e1>", "interleukin-4", "(", "IL-4", ")", "on", "collagen", "gene", "expression", "in", "C0036421#ent", "<e2>", "SSc", ")", "fibroblasts", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [18, 19]}}
{"token": ["Cardiac", "hypertrophy", "reduced", "by", "C0065374#ent", "<e1>", "but", "not", "C0020223#ent", "<e2>", "and", "was", "positively", "correlated", "with", "cardiac", "angiotensinogen", "expression", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [8, 9]}}
{"token": ["An", "increase", "in", "the", "activity", "of", "C0017824#ent", "<e1>", "a", "peroxide", "degrading", "enzyme", ",", "was", "observed", "upon", "C1825840#ent", "<e2>", "treatment", ",", "similar", "to", "the", "response", "reported", "by", "accumulation", "of", "active", "oxygen", "species"], "h": {"id": "C0017824", "name": "C0017824#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [16, 17]}}
{"token": ["The", "stimulation", "of", "cAMP", "by", "GLP-1", "and", "C0917964#ent", "<e1>", "was", "effectively", "inhibited", "by", "the", "adenylate", "cyclase", "inhibitors", "C0127276#ent", "<e2>", "and", "SQ-22536", ",", "confirming", "that", "the", "increased", "cAMP", "is", "through", "the", "AC", "pathway"], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0127276", "name": "C0127276#ent", "pos": [17, 18]}}
{"token": ["This", "nuclear", "export", "Id1", "was", "inhibited", "by", "protein", "kinase", "A", "PKA", ")", "activation", "by", "dibutyryl", "cyclic", "AMP", "C0917964#ent", "<e1>", "but", "was", "promoted", "by", "PKA", "inactivation", "by", "H-89", "and", "C0127276#ent", "<e2>", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0127276", "name": "C0127276#ent", "pos": [28, 29]}}
{"token": ["Parenteral", "use", "of", "C2350083#ent", "<e1>", "in", "emergency", "department", "patients", "with", "C0694551#ent", "<e2>", "in", "significant", "levels", "of", "pain", "reduction", "concurrent", "normalisation", "of", "abdominal", "examination", "findings", "indicative", "of", "acute", "appendicitis"], "h": {"id": "C2350083", "name": "C2350083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0694551", "name": "C0694551#ent", "pos": [10, 11]}}
{"token": ["Using", "a", "proteomic", "approach", "immunoblotting", "techniques", "we", "have", "identified", "the", "enzymes", "leucine", "aminopeptidase", "LAP", ")", "and", "C0251211#ent", "<e1>", "immunodominant", "antigens", "by", "sera", "from", "C0015652#ent", "<e2>", "patients", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0015652", "name": "C0015652#ent", "pos": [23, 24]}}
{"token": ["The", "fourth", "case", "was", "a", "male", "of", "33", "C1337037#ent", "<e1>", "with", "difficult-to-control", "asthma", "and", "had", "been", "taking", "C0117996#ent", "<e2>", "-", "2,000", "microg", "x", "day(-1", ")", "for", "3", "C1337037#ent", "<e1>", "."], "h": {"id": "C0117996", "name": "C0117996#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1337037", "name": "C1337037#ent", "pos": [8, 9]}}
{"token": ["After", "IT", ",", "time", "courses", "C1333196#ent", "<e1>", "levels", "in", "bronchial", "alveolar", "lavage", "fluid", "BALF", ")", ",", "peripheral", "blood", "cell", "count", "C0027021#ent", "<e2>", "MPO", ")", "activity", "and", "myocardial", "chemokine", "levels", "were", "observed", "for", "24", "hr", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "the", "effect", "of", "C0017718#ent", "<e1>", "as", "another", "risk", "factor", "fibrosis", ",", "eg", ",", "in", "the", "C3534591#ent", "<e2>", "was", "investigated", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3534591", "name": "C3534591#ent", "pos": [18, 19]}}
{"token": ["The", "herbicides", "chosen", "belong", "to", "different", "chemical", "groups", "were", "alachlor", ",", "C0030969#ent", "<e1>", ",", "chlorotoluron", ",", "diclofop", ",", "diflufenicam", ",", "C0960576#ent", "<e2>", ",", "isoproturon", ",", "linuron", ",", "terbutryn", "and", "trifluralin", "."], "h": {"id": "C0030969", "name": "C0030969#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0960576", "name": "C0960576#ent", "pos": [20, 21]}}
{"token": ["When", "a", "C0033640#ent", "<e1>", "PKA", ")", "inhibitor", "(", "H89", ")", "was", "applied", ",", "C1333674#ent", "<e2>", "stimulated", "GH", "release", "was", "blocked", ",", "but", "cAMP", "accumulation", "was", "not", "affected", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333674", "name": "C1333674#ent", "pos": [13, 14]}}
{"token": ["C0054836#ent", "<e1>", "is", "an", "inherently", "long-acting", "beta-blocker", "while", "the", "C2926735#ent", "<e2>", "of", "beta", "blockade", "metoprolol", "is", "dependent", "on", "the", "salt", "and", "formulation", ",", "which", "is", "used", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [9, 10]}}
{"token": ["The", "electrophysiologic", "properties", "of", "C0054836#ent", "<e1>", "include", "moderate", "prolongation", "of", "action", "potential", "C2926735#ent", "<e2>", "and", "effective", "refractory", "period", ";", "slowing", "of", "atrioventricular", "conduction", "and", "reducing", "the", "dispersion", "of", "refractoriness", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [12, 13]}}
{"token": ["A", "single", ",", "large", "Phase", "III", "trial", "demonstrated", "the", "efficacy", "of", "C1170000#ent", "<e1>", "activated", ")", "in", "a", "sample", "of", "patients", "with", "severe", "C0243026#ent", "<e2>", "."], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [22, 23]}}
{"token": ["With", "the", "exception", "of", "C1170000#ent", "<e1>", "attempts", "to", "modulate", "the", "inflammatory", "response", "C0243026#ent", "<e2>", "have", "generally", "been", "unsuccessful", "."], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}}
{"token": ["We", "analyzed", "the", "440-kDa", "transmembrane", "pore", "formed", "by", "the", "protective", "antigen", "PA", ")", "moiety", "of", "C1427242#ent", "<e1>", "the", "presence", "of", "C1415782#ent", "<e2>", "by", "negative-stain", "electron", "microscopy"], "h": {"id": "C1427242", "name": "C1427242#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415782", "name": "C1415782#ent", "pos": [20, 21]}}
{"token": ["Protein", "kinases", "the", "C0812228#ent", "<e1>", "and", "related", "serum-", "and", "C1528301#ent", "<e2>", "SGK", ")", "families", "are", "major", "downstream", "mediators", "of", "phosphatidylinositol", "(", "PI", ")", "3-kinase", "signaling", "many", "cellular", "processes", "metabolic", "flux", "membrane", "trafficking", "and", "apoptosis", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1528301", "name": "C1528301#ent", "pos": [9, 10]}}
{"token": ["These", "results", "together", "suggest", "that", "CK2", "impairs", "spatial", "memory", "formation", "through", "differential", "cross", "talk", "with", "PI-3", "kinase", "signaling", "activation", "of", "C0812228#ent", "<e1>", "and", "inactivation", "of", "C1528301#ent", "<e2>", "through", "protein", "phosphatase", "2A"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1528301", "name": "C1528301#ent", "pos": [25, 26]}}
{"token": ["C3149841#ent", "<e1>", "PKD", ")", "is", "one", "of", "important", "causes", "of", "end-stage", "renal", "disease", "C0035078#ent", "<e2>", ")", "."], "h": {"id": "C3149841", "name": "C3149841#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [13, 14]}}
{"token": ["Hypertensive", "patients", "with", "autosomal", "dominant", "C3149841#ent", "<e1>", "ADPKD", ")", "have", "a", "faster", "progression", "to", "end-stage", "renal", "disease", "C0035078#ent", "<e2>", ")", "than", "their", "normotensive", "counterparts", "."], "h": {"id": "C3149841", "name": "C3149841#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [17, 18]}}
{"token": ["OTA", "treatment", "significantly", "decreased", "basal", "ANP", "and", "C0669365#ent", "<e1>", "mRNAs", "expression", "on", "C1416886#ent", "<e2>", "in", "both", "sexes", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416886", "name": "C1416886#ent", "pos": [12, 13]}}
{"token": ["In", "platelets", "from", "mice", "lacking", "the", "P2Y12", "receptor", "neither", "C0002313#ent", "<e1>", "nor", "AYPGKF", "caused", "inhibition", "of", "C1382029#ent", "<e2>"], "h": {"id": "C0002313", "name": "C0002313#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [16, 17]}}
{"token": ["In", "platelets", "from", "a", "P2Y12", "receptor-defective", "patient", ",", "C0002313#ent", "<e1>", ",", "SFLLRN", ",", "and", "GYPGKF", "also", "failed", "to", "inhibit", "C1382029#ent", "<e2>"], "h": {"id": "C0002313", "name": "C0002313#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "we", "asked", "whether", "genetic", "variation", "the", "C1423931#ent", "<e1>", "gene", "contributes", "to", "C0362046#ent", "<e2>", "phenotypes", ",", "such", "as", "dyslipidemia", ",", "insulin", "resistance", "or", "beta-cell", "dysfunction", "in", "white", "subjects", "at", "an", "increased", "risk", "for", "type", "2", "diabetes", "mellitus"], "h": {"id": "C1423931", "name": "C1423931#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [13, 14]}}
{"token": ["C0003504#ent", "<e1>", "AR", ")", "caused", "by", "degenerative", ",", "rheumatic", ",", "and", "C0024796#ent", "<e2>", "etiologies", "were", "compared", "in", "a", "study", "of", "87", "patients", "."], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [11, 12]}}
{"token": ["It", "manifests", "by", "increased", "oxalate", "production", "that", "ultimately", "results", "in", "C0035078#ent", "<e1>", "due", "to", "urolithiasis", "and", "nephrocalcinosis", ",", "and", "finally", "induces", "C0268164#ent", "<e2>", "risk", "of", "premature", "death"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [21, 22]}}
{"token": ["Primary", "hyperoxaluria", "type", "I", "initially", "manifest", "as", "urolithiasis", ",", "C0035078#ent", "<e1>", "or", "symptoms", "of", "C0268164#ent", "<e2>"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [14, 15]}}
{"token": ["A", "cadaveric", "liver-kidney", "transplantation", "(", "Tx", ")", "was", "done", "in", "a", "12-year", "old", "boy", "with", "C0035078#ent", "<e1>", "due", "to", "C0268164#ent", "<e2>"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [19, 20]}}
{"token": ["6", ")", "Erlotinib", ",", "like", "C1122962#ent", "<e1>", ",", "is", "metabolized", "by", "the", "cytochrome", "P450", "isoenzyme", "C1142644#ent", "<e2>", ",", "potentially", "creating", "a", "high", "risk", "of", "interactions", "."], "h": {"id": "C1122962", "name": "C1122962#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [15, 16]}}
{"token": ["Sheep", "possessing", "C0002085#ent", "<e1>", "for", "the", "C4082486#ent", "<e2>", "glutamine", "(", "Q", ")", "or", "histidine", ",", "both", "reported", "as", "Q", ",", "at", "codon", "171", "are", "highly", "susceptible", "to", "scrapie", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [6, 7]}}
{"token": ["The", "present", "study", "has", "been", "conducted", "to", "ascertain", "the", "level", "of", "C0002085#ent", "<e1>", "variation", "at", "codon", "129", "the", "C4082486#ent", "<e2>", "France", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [18, 19]}}
{"token": ["The", "tumor", "cells", "strong", "reactivity", "for", "lysozyme", ",", "myeloperoxidase", ",", "C1870006#ent", "<e1>", ",", "and", "CD68", "and", "were", "negative", "for", "C0010803#ent", "<e2>", ",", "S100", ",", "CD20", ",", "and", "CD3", "."], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [19, 20]}}
{"token": ["A", "limited", "panel", "of", "antibodies", "can", "lead", "to", "an", "erroneous", "diagnosis", ";", "B-lymphoblastic", "lymphoma", "be", "negative", "for", "C1870006#ent", "<e1>", "and", "CD20", "but", "positive", "for", "CD99", "and", "even", "for", "C0010803#ent", "<e2>", ",", "mimicking", "Ewing's", "sarcoma"], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [28, 29]}}
{"token": ["Using", "the", "mongolian", "gerbil", "model", "of", "transient", "forebrain", "ischemia", "C0265101#ent", "<e1>", "the", "levels", "of", "phosphorylation", "and", "the", "amount", "of", "C1418825#ent", "<e2>", "in", "striatum", "were", "measured", "by", "back-phosphorylation", "and", "Western-blotting", "assay", "in", "vitro"], "h": {"id": "C0265101", "name": "C0265101#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418825", "name": "C1418825#ent", "pos": [19, 20]}}
{"token": ["The", "autopsy", "reports", "provided", "information", "concerning", "the", "presence", "of", "C0017327#ent", "<e1>", "benign", "or", "C3273254#ent", "<e2>"], "h": {"id": "C0017327", "name": "C0017327#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273254", "name": "C3273254#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "rats", "with", "C1561643#ent", "<e1>", "diverse", "causes", "respond", "briskly", "to", "C1415521#ent", "<e2>", "despite", "presumed", "hyperperfused", "and", "hyperfiltering", "nephrons", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415521", "name": "C1415521#ent", "pos": [12, 13]}}
{"token": ["Two", "children", "suffering", "from", "C3495559#ent", "<e1>", "JCA", ")", "complicated", "by", "acute", "disseminated", "intravascular", "coagulation", "C0012739#ent", "<e2>", ")", "are", "described", "."], "h": {"id": "C3495559", "name": "C3495559#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [14, 15]}}
{"token": ["Two", "children", "suffering", "from", "C3495559#ent", "<e1>", "JCA", ")", "complicated", "by", "C0012739#ent", "<e2>", "DIC", ")", "are", "described", "."], "h": {"id": "C3495559", "name": "C3495559#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [10, 11]}}
{"token": ["Unidirectional", "blood", "flow", "in", "the", "C1442495#ent", "<e1>", "causes", "functional", "differences", "of", "C0669372#ent", "<e2>", "according", "to", "the", "lobular", "zones"], "h": {"id": "C1442495", "name": "C1442495#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [11, 12]}}
{"token": ["Given", "that", "C0151744#ent", "<e1>", "BB", "influence", "metabolic", "processes", "by", "peroxisome", "proliferator-activated", "receptor", "alpha", "C2984537#ent", "<e2>", ")", ",", "we", "hypothesized", "that", "interactions", "between", "polymorphisms", "of", "the", "PPARalpha", "gene", "PPARA", ")", "and", "BB", "treatment", "would", "influence", "clinical", "outcome", "ACS", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2984537", "name": "C2984537#ent", "pos": [13, 14]}}
{"token": ["Mutation", "of", "this", "motif", "enhances", "heterodimerization", "with", "C1412958#ent", "<e1>", "and", "increases", "C1425399#ent", "<e2>", "ability", "to", "antagonize", "Hes1-mediated", "transcriptional", "repression"], "h": {"id": "C1412958", "name": "C1412958#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1425399", "name": "C1425399#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", "to", "C1412958#ent", "<e1>", ",", "the", "related", "protein", "C1425399#ent", "<e2>", "promotes", "neuronal", "differentiation"], "h": {"id": "C1412958", "name": "C1412958#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425399", "name": "C1425399#ent", "pos": [9, 10]}}
{"token": ["This", "family", "regulates", "expression", "of", "C0078956#ent", "<e1>", "responsive", "genes", "by", "binding", "to", "the", "C0078956#ent", "<e1>", "responsive", "element", "(", "C1421113#ent", "<e1>", ")", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421113", "name": "C1421113#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "heparin", "and", "HS", "inhibited", "the", "activation", "of", "C0078956#ent", "<e1>", "response", "element", "(", "C1421113#ent", "<e2>", ")", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421113", "name": "C1421113#ent", "pos": [15, 16]}}
{"token": ["C0010054#ent", "<e1>", "myocardium", "genetically", "engineered", "to", "overexpress", "C2830173#ent", "<e2>", "increased", "the", "amount", "of", "acylcarnitine", "present", "in", "myocardium", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2830173", "name": "C2830173#ent", "pos": [7, 8]}}
{"token": ["The", "total", "per-patient", "cost", "was", "$", "US4867", "with", "glipizide", "GITS", ",", "$", "US5196", "with", "C0770893#ent", "<e1>", "and", "$", "US5249", "with", "C0050393#ent", "<e2>", "(", "1996/1997", "values", ")", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0050393", "name": "C0050393#ent", "pos": [20, 21]}}
{"token": ["MPO-ANCA", "can", "be", "found", "in", "microscopic", "polyangiitis", "MPA", ")", ",", "Churg", "Strauss", "Syndromes(CSS", ",", "drug-induced", "vasculitis", "and", "environmental", "factor-induced", "such", "as", "C0037116#ent", "<e1>", "frequently", "than", "C3495801#ent", "<e2>", "."], "h": {"id": "C0037116", "name": "C0037116#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3495801", "name": "C3495801#ent", "pos": [25, 26]}}
{"token": ["We", "report", "here", "that", "clinically", "relevant", "concentrations", "of", "inhalational", "anesthetics", "dose-dependently", "and", "specifically", "inhibit", "the", "PDZ", "domain-mediated", "protein", "interaction", "C1333226#ent", "<e1>", "or", "PSD-93", "and", "the", "N-methyl-d-aspartate", "receptor", "C0132555#ent", "<e2>"], "h": {"id": "C1333226", "name": "C1333226#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [27, 28]}}
{"token": ["One", "of", "these", "interactions", "arises", "from", "C1421250#ent", "<e1>", "which", "is", "conserved", "in", "all", "41", "C0035541#ent", "<e2>", "of", "known", "sequence", "."], "h": {"id": "C1421250", "name": "C1421250#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [14, 15]}}
{"token": ["We", "also", "show", "that", "translocation", "of", "C2757041#ent", "<e1>", "the", "nucleus", "requires", "functional", "C0004135#ent", "<e2>", "."], "h": {"id": "C2757041", "name": "C2757041#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [12, 13]}}
{"token": ["Chronic", "paroxysmal", "hemicrania", "C0149519#ent", "<e1>", ")", "is", "a", "rare", "type", "of", "C0270697#ent", "<e2>", "that", "is", "characterized", "by", "daily", ",", "multiple", ",", "short-lasting", "attacks", "of", "severe", "pain", "and", "associated", "autonomic", "symptoms"], "h": {"id": "C0149519", "name": "C0149519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [11, 12]}}
{"token": ["HC", "may", "possibly", "best", "be", "classified", "along", "with", "chronic", "paroxysmal", "hemicrania", "C0149519#ent", "<e1>", ")", "as", "this", "is", "the", "only", "other", "C0270697#ent", "<e2>", "absolutely", "responsive", "to", "indomethacin", "."], "h": {"id": "C0149519", "name": "C0149519#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [20, 21]}}
{"token": ["The", "combination", "of", "C3536710#ent", "<e1>", "and", "transdermal", "estrogen", "not", "associated", "with", "further", "change", "of", "C1439335#ent", "<e2>"], "h": {"id": "C3536710", "name": "C3536710#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1439335", "name": "C1439335#ent", "pos": [14, 15]}}
{"token": ["However", ",", "the", "effect", "of", "C0005064#ent", "<e1>", "on", "the", "C1367469#ent", "<e2>", "response", "to", "CRH", "or", "AVP", "is", "contradictory", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [9, 10]}}
{"token": ["Right", "atrial", "multisite", "electrogram", "recordings", "revealed", "significant", "prolongation", "in", "C0004238#ent", "<e1>", "cycle", "length", "at", "all", "sites", "following", "C0123053#ent", "<e2>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0123053", "name": "C0123053#ent", "pos": [17, 18]}}
{"token": ["C0740279#ent", "<e1>", "considered", "the", "most", "prominent", "neuroradiologic", "finding", "in", "C0024814#ent", "<e2>", "MSS", ")", "."], "h": {"id": "C0740279", "name": "C0740279#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0024814", "name": "C0024814#ent", "pos": [9, 10]}}
{"token": ["C0740279#ent", "<e1>", "considered", "the", "most", "prominent", "neuroradiologic", "finding", "in", "Marinesco-Sj\u00f6gren", "syndrome", "C0024814#ent", "<e2>", ")", "."], "h": {"id": "C0740279", "name": "C0740279#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0024814", "name": "C0024814#ent", "pos": [11, 12]}}
{"token": ["Serum", "concentrations", "and", "urinary", "recovery", "C0011812#ent", "<e1>", "and", "(R)-(-)-chlorpheniramine", "were", "unaffected", "by", "administration", "of", "C0034665#ent", "<e2>", ",", "indicating", "no", "pharmacokinetic", "drug-drug", "interaction"], "h": {"id": "C0011812", "name": "C0011812#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [14, 15]}}
{"token": ["Analysis", "of", "these", "polysaccharides", "as", "well", "as", "other", "charged", "carbohydrates", "and", "after", "chemical", "modification", "that", "these", "oppositely", "charged", "groups", "are", "required", "for", "promotion", "of", "C0243001#ent", "<e1>", "well", "as", "for", "protection", "against", "C0000833#ent", "<e2>"], "h": {"id": "C0243001", "name": "C0243001#ent", "pos": [24, 25]}, "relation": "has_nichd_parent", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [31, 32]}}
{"token": ["Five", "patients", "had", "an", "C0243001#ent", "<e1>", "eight", "had", "a", "C0000833#ent", "<e2>", "psoas", ")", "."], "h": {"id": "C0243001", "name": "C0243001#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [9, 10]}}
{"token": ["Although", "C0243001#ent", "<e1>", "relatively", "frequent", "in", "the", "setting", "of", "regional", "enteritis", "C0000833#ent", "<e2>", "rare", "."], "h": {"id": "C0243001", "name": "C0243001#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [11, 12]}}
{"token": ["This", "paper", "describes", "and", "evaluates", "a", "Patient-Oriented", "education", "management", "system", "for", "C0011849#ent", "<e1>", "using", "the", "Internet", "(", "C1826466#ent", "<e2>", ")", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1826466", "name": "C1826466#ent", "pos": [17, 18]}}
{"token": ["Mature", "C0054870#ent", "<e1>", "59.3", "%", "identity", "to", "mouse", "C0054871#ent", "<e2>", "contains", "the", "characteristic", "ER(F/W)NIN", "motif", "within", "the", "propeptide", "indicating", "that", "this", "protease", "belongs", "to", "the", "subgroup", "of", "cathepsin", "L-like", "cysteine", "proteases", "."], "h": {"id": "C0054870", "name": "C0054870#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [8, 9]}}
{"token": ["The", "protein", "levels", "C0599220#ent", "<e1>", "IV", "were", "not", "different", "between", "control", "subjects", "C0078939#ent", "<e2>", "patients", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [12, 13]}}
{"token": ["C1416917#ent", "<e1>", "and", "C1416918#ent", "<e2>", "are", "expressed", "in", "airway", "epithelium", "during", "lung", "development", "whereas", "C1416917#ent", "<e1>", "but", "not", "C1416918#ent", "<e2>", "expression", "is", "observed", "in", "the", "muscular", "component", "large", "blood", "vessels", "including", "the", "aorta", "."], "h": {"id": "C1416918", "name": "C1416918#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416917", "name": "C1416917#ent", "pos": [0, 1]}}
{"token": ["Continuous", "exposure", "to", "PTH", "(", "1", "-", "38", ")", "both", "in", "vivo", "in", "vitro", "upregulated", "the", "mRNA", "expression", "of", "C1416918#ent", "<e1>", "and", "FZD-1", "and", "decreased", "C1416917#ent", "<e2>", "and", "Dkk-1", "."], "h": {"id": "C1416918", "name": "C1416918#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1416917", "name": "C1416917#ent", "pos": [25, 26]}}
{"token": ["A", "high", "frequency", "chromosomal", "breakage", "rearrangement", "has", "been", "found", "in", "cultured", "blood", "cells", "six", "of", "seven", "individuals", "with", "a", "rare", "C0039082#ent", "<e1>", "characterized", "by", "C0005859#ent", "<e2>", "stunted", "growth"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0005859", "name": "C0005859#ent", "pos": [24, 25]}}
{"token": ["Because", "C1332703#ent", "<e1>", "expression", "appears", "to", "be", "activation", "dependent", ",", "we", "examined", "C1332703#ent", "<e1>", "on", "duodenal", "T", "cells", "untreated", "and", "treated", "(", "gluten-free", "diet", "patients", "with", "C0007570#ent", "<e1>", "healthy", "controls"], "h": {"id": "C1332703", "name": "C1332703#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [26, 27]}}
{"token": ["We", "studied", "the", "cardiac", "mitochondrial", "structure", "the", "enzymatic", "activity", "citrate", "synthase", "respiratory", "chain", "complexes", ",", "in", "Albino", "Swiss", "mice", "infected", "with", "T.", "cruzi", "Tulahuen", "strain", "and", "SGO", "Z12", "C1875400#ent", "<e1>", ",", "in", "two", "periods", "of", "the", "C0149512#ent", "<e2>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [36, 37]}}
{"token": ["No", "cycle-related", "variation", "in", "Naic", "or", "C4086533#ent", "<e1>", "was", "observed", "in", "women", "using", "the", "C0009906#ent", "<e2>"], "h": {"id": "C4086533", "name": "C4086533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009906", "name": "C0009906#ent", "pos": [14, 15]}}
{"token": ["The", "gender", "prevalence", "of", "multiple", "sclerosis", "the", "low", "level", "concordance", "in", "homozygous", "twins", "and", "the", "linkage", "to", "several", "C0678933#ent", "<e1>", "suggest", "an", "epigenetic", "component", "the", "definition", "of", "this", "C0011302#ent", "<e2>"], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0011302", "name": "C0011302#ent", "pos": [28, 29]}}
{"token": ["To", "find", "the", "peptides", "comparable", "or", "superior", "to", "the", "antimicrobial", "activity", "C1426147#ent", "<e1>", ",", "the", "two", "reversed", "peptides", "(", "C1335590#ent", "<e2>", "and", "Rev-2", ")", "of", "C1426147#ent", "<e1>", "were", "designed", "and", "synthesized", "."], "h": {"id": "C1335590", "name": "C1335590#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1426147", "name": "C1426147#ent", "pos": [11, 12]}}
{"token": ["C1412333#ent", "<e1>", ",", "also", "known", "as", "C1721673#ent", "<e2>", "ALDH1", ")", "or", "retinaldehyde", "dehydrogenase", "RALDH1", ")", ",", "prefers", "retinal", "to", "acetaldehyde", "as", "a", "substrate", "."], "h": {"id": "C1412333", "name": "C1412333#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1721673", "name": "C1721673#ent", "pos": [6, 7]}}
{"token": ["By", "PCR", ",", "C.", "dubliniensis", "also", "found", "to", "encode", "C4277608#ent", "<e1>", "of", "CDR1", "and", "C1413296#ent", "<e2>", ",", "termed", "CdCDR1", "and", "CdCDR2", ",", "respectively", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413296", "name": "C1413296#ent", "pos": [14, 15]}}
{"token": ["p27", "is", "a", "CDK", "inhibitor", "C1872855#ent", "<e1>", ")", "that", "binds", "to", "CDK2", "to", "prevent", "premature", "activation", "this", "C0031727#ent", "<e2>", "."], "h": {"id": "C1872855", "name": "C1872855#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["The", "alpha", "1-adrenoceptor", "antagonist", "C0032912#ent", "<e1>", ",", "and", "the", "5-HT2", "receptor", "antagonist", "C0022616#ent", "<e2>", ",", "did", "not", "modify", "the", "effect", "of", "SK&F", "38393", "pergolide", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [12, 13]}}
{"token": ["Both", "remoxipride", "and", "C0032912#ent", "<e1>", "reversed", "the", "cocaine-induced", "deficit", "in", "prepulse", "inhibition", "whereas", "C0022616#ent", "<e2>", "did", "not", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "reflex", "tachycardia", "unaffected", "by", "C0032912#ent", "<e1>", "but", "was", "reversed", "to", "bradycardia", "by", "C0022616#ent", "<e2>", "in", "older", "rats"], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [14, 15]}}
{"token": ["Trp60", "and", "C2827472#ent", "<e1>", "were", "both", "replaced", "with", "Phe", ",", "and", "a", "single", "C1705940#ent", "<e2>", "was", "introduced", "at", "various", "positions", "."], "h": {"id": "C2827472", "name": "C2827472#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [13, 14]}}
{"token": ["Treatment", "with", "a", "12-LOX", "inhibitor", "C0052927#ent", "<e1>", ",", "significantly", "inhibited", "cancer", "cell", "proliferation", "but", "a", "metabolite", "of", "C3539672#ent", "<e2>", "12", "hydroxyeicosatetraenoic", "acid", "12-HETE", ")", "reversed", "baicalein-induced", "growth", "inhibition", "."], "h": {"id": "C0052927", "name": "C0052927#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539672", "name": "C3539672#ent", "pos": [17, 18]}}
{"token": ["In", "our", "experience", ",", "C0042679#ent", "<e1>", "is", "a", "promising", "agent", "to", "treat", "C1268935#ent", "<e2>", "patients", "resistant", "to", "conventional", "plasma-exchange", "and", "pharmacologic", "therapy"], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1268935", "name": "C1268935#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "C0042679#ent", "<e1>", "should", "be", "considered", "for", "C1268935#ent", "<e2>", "refractory", "to", "treatment", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1268935", "name": "C1268935#ent", "pos": [8, 9]}}
{"token": ["Mitochondrial", "thymidine", "kinase", "C0537740#ent", "<e1>", ")", "phosphorylates", "pyrimidine", "nucleosides", "monophosphates", "and", "is", "expressed", "C0907533#ent", "<e2>", "through", "the", "cell", "cycle", "all", "cells", "."], "h": {"id": "C0537740", "name": "C0537740#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [13, 14]}}
{"token": ["TK1", "is", "cell", "cycle-regulated", "C0537740#ent", "<e1>", "is", "expressed", "C0907533#ent", "<e2>", "and", "can", "phosphorylate", "deoxycytidine", "to", "the", "same", "extent", "as", "thymidine", "."], "h": {"id": "C0537740", "name": "C0537740#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}}
{"token": ["C0162316#ent", "<e1>", "a", "frequent", "complication", "in", "children", "with", "inflammatory", "bowel", "disease", "C0022104#ent", "<e2>", ")", "."], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [11, 12]}}
{"token": ["Stem", "cell-based", "therapies", "hold", "therapeutic", "promise", "for", "C4024896#ent", "<e1>", "such", "as", "C0002736#ent", "<e2>", "and", "for", "spinal", "cord", "injury"], "h": {"id": "C4024896", "name": "C4024896#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [11, 12]}}
{"token": ["It", "appears", "to", "be", "effective", "in", "treating", "adult", "Stills", "disease", "C1384600#ent", "<e1>", "chronic", "infantile", "neurological", "cutaneous", "articular", "syndrome", "also", "known", "as", "C0409818#ent", "<e2>", "."], "h": {"id": "C1384600", "name": "C1384600#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0409818", "name": "C0409818#ent", "pos": [21, 22]}}
{"token": ["Peritoneal", "ultrafiltration", "fluid", "reabsorption", "characteristics", "for", "18", "patients", "undergoing", "continuous", "ambulatory", "peritoneal", "dialysis", "CAPD", ")", "were", "investigated", "in", "single", "dwell", "studies", "of", "6", "h", "C0720099#ent", "<e1>", "with", "21", "of", "3.86", "%", "C0011947#ent", "<e2>"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0011947", "name": "C0011947#ent", "pos": [31, 32]}}
{"token": ["A", "double-blind", "controlled", "trial", "carried", "out", "in", "50", "patients", "with", "anxiety", "neuroses", "compare", "the", "effectiveness", "of", "C1619621#ent", "<e1>", ",", "a", "recently", "developed", "C4048284#ent", "<e2>", "with", "anxiolytic", "activity", "and", "bromazepam", "."], "h": {"id": "C1619621", "name": "C1619621#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [22, 23]}}
{"token": ["The", "study", "was", "intended", "to", "investigate", "whether", "C1619621#ent", "<e1>", "(", "Talis", ")", ",", "a", "new", "C4048284#ent", "<e2>", ",", "and", "some", "of", "its", "metabolites", "were", "present", "in", "breast", "milk"], "h": {"id": "C1619621", "name": "C1619621#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [15, 16]}}
{"token": ["The", "patients", "treated", "two", "C0149931#ent", "<e1>", "attacks", "at", "home", "by", "subcutaneous", "injection", "of", "C0075632#ent", "<e2>", "or", "placebo", "and", "the", "alternative", "medication", "for", "the", "second", "attack", "cross-over", ")", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0075632", "name": "C0075632#ent", "pos": [13, 14]}}
{"token": ["In", "clinical", "trials", ",", "more", "than", "88000", "C0149931#ent", "<e1>", "patients", "had", "treated", "more", "than", "300000", "C0149931#ent", "<e1>", "attacks", "with", "C0075632#ent", "<e1>", ",", "and", "2000", "normal", "healthy", "had", "been", "exposed", "to", "drug", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0075632", "name": "C0075632#ent", "pos": [19, 20]}}
{"token": ["Because", "the", "C1419789#ent", "<e1>", "Severity", "Index", "PASI", ")", "does", "not", "consider", "the", "severity", "of", "C0027339#ent", "<e2>", "a", "scale", "that", "assesses", "the", "extent", "of", "involvement", "of", "psoriatic", "nails", "needed", "."], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027339", "name": "C0027339#ent", "pos": [14, 15]}}
{"token": ["Characteristic", "ultrasound", "pictures", "can", "be", "seen", "in", "C1419789#ent", "<e1>", ",", "cysts", ",", "vascular", "abnormalities", "and", "other", "C0027339#ent", "<e2>"], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027339", "name": "C0027339#ent", "pos": [16, 17]}}
{"token": ["None", "of", "the", "patients", "had", "experienced", "hypoglycaemia", "during", "waking", "hours", "the", "C4048158#ent", "<e1>", "were", "mistakenly", "diagnosed", "as", "C0014553#ent", "<e2>"], "h": {"id": "C4048158", "name": "C4048158#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [17, 18]}}
{"token": ["These", "results", "together", "with", "other", "findings", "justify", "the", "conclusion", ",", "that", "the", "majority", "of", "febrile", "C4048158#ent", "<e1>", "should", "be", "classified", "amongst", "the", "C0014553#ent", "<e2>"], "h": {"id": "C4048158", "name": "C4048158#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [22, 23]}}
{"token": ["Other", "factors", "newly", "identified", "as", "affecting", "TLC1", "RNA", "levels", "include", "C0243045#ent", "<e1>", "the", "mediator", "complex", "protein", "phosphatase", "2A", "and", "C1539696#ent", "<e2>", "and", "S16A", "."], "h": {"id": "C0243045", "name": "C0243045#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [19, 20]}}
{"token": ["We", "have", "examined", "the", "effects", "of", "calphostin", "C", "a", "protein", "kinase", "C", "inhibitor", ",", "genistein", "and", "C0083406#ent", "<e1>", "tyrosine", "kinase", "inhibitors", ",", "and", "exogenous", "C0085536#ent", "<e2>", "(", "an", "activator", "of", "protein", "tyrosine", "phosphatases", "on", "the", "growth", ",", "morphology", "and", "differentiation", "of", "malignant", "melanomas", "in", "vitro"], "h": {"id": "C0083406", "name": "C0083406#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [24, 25]}}
{"token": ["The", "results", "suggest", "that", "the", "genes", "C1512488#ent", "<e1>", "to", "barley", "Mlo", "and", "maize", "C1705014#ent", "<e2>", "in", "rice", "may", "be", "involved", "in", "defense", "responses", "induced", "by", "pathogen", "infection"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705014", "name": "C1705014#ent", "pos": [13, 14]}}
{"token": ["Two", "sequences", ",", "OsMlo-1", "and", "DFR-1", "which", "were", "C1512488#ent", "<e1>", "to", "the", "barley", "Mlo", "maize", "C1705014#ent", "<e2>", ",", "respectively", ",", "were", "isolated", "from", "rice", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705014", "name": "C1705014#ent", "pos": [15, 16]}}
{"token": ["From", "our", "clinical", "trials", "different", "available", "antifungal", "drugs", "the", "cases", "of", "C1262117#ent", "<e1>", ",", "we", "conclude", "that", "C0546862#ent", "<e2>", "1", "%", "ointment", "is", "a", "safe", "and", "effective", "antifungal", "agent", "a", "wide", "range", "of", "antifungal", "activity"], "h": {"id": "C1262117", "name": "C1262117#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0546862", "name": "C0546862#ent", "pos": [17, 18]}}
{"token": ["The", "initiation", "of", "cyclic", "menses", "continued", "C0020514#ent", "<e1>", "may", "indicate", "a", "possible", "direct", "effect", "of", "C0546852#ent", "<e2>", "on", "hypothalamic", "LRF", "secretion", "as", "a", "partial", "explanation", "for", "its", "therapeutic", "action"], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0546852", "name": "C0546852#ent", "pos": [15, 16]}}
{"token": ["Recombinant", "C1424620#ent", "<e1>", "binds", "more", "tightly", "to", "the", "C1334090#ent", "<e2>", "K(D", ")", "=", "1", "microm", ")", "than", "to", "the", "cation-dependent", "mannose", "6-phosphate", "receptor", "K(D", ")", "=", "3", "microm", ")", "."], "h": {"id": "C1424620", "name": "C1424620#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334090", "name": "C1334090#ent", "pos": [8, 9]}}
{"token": ["Despite", "new", "C0017302#ent", "<e1>", "antiemetics", ",", "the", "incidence", "of", "C0520909#ent", "<e2>", "remains", "high", "."], "h": {"id": "C0017302", "name": "C0017302#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0520909", "name": "C0520909#ent", "pos": [9, 10]}}
{"token": ["This", "prompted", "extensive", "research", "of", "antiemetic", "and", "C0017302#ent", "<e1>", "but", "none", "of", "the", "interventions", "appeared", "to", "satisfactorily", "prevent", "C0520909#ent", "<e2>", "."], "h": {"id": "C0017302", "name": "C0017302#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0520909", "name": "C0520909#ent", "pos": [18, 19]}}
{"token": ["In", "recent", "years", "many", "studies", "have", "been", "published", ",", "suggesting", "that", "choosing", "propofol", "as", "the", "C0017302#ent", "<e1>", "help", "to", "reduce", "the", "high", "incidence", "of", "C0520909#ent", "<e2>", "in", "children", "undergoing", "strabismus", "surgery"], "h": {"id": "C0017302", "name": "C0017302#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0520909", "name": "C0520909#ent", "pos": [24, 25]}}
{"token": ["It", "outlines", "how", "the", "instrument", "has", "helped", "managers", "in", "the", "C1417725#ent", "<e1>", "identify", "their", "strengths", "and", "C0018801#ent", "<e2>", "with", "respect", "to", "their", "management", "and", "use", "of", "informatics", "."], "h": {"id": "C1417725", "name": "C1417725#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [16, 17]}}
{"token": ["C1332830#ent", "<e1>", "phenotypes", "were", "identified", "by", "the", "T1/2", "of", "C3539807#ent", "<e2>", "and", "9-hydroxyrisperidone", "according", "to", "the", "literature", "."], "h": {"id": "C1332830", "name": "C1332830#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539807", "name": "C3539807#ent", "pos": [9, 10]}}
{"token": ["Methylated-beta-cyclodextrin", "(", "C1417196#ent", "<e1>", ")", "has", "shown", "better", "ability", "than", "C0046237#ent", "<e2>", "(", "HPCD", ")", "to", "complex", "TNT", "."], "h": {"id": "C1417196", "name": "C1417196#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0046237", "name": "C0046237#ent", "pos": [10, 11]}}
{"token": ["C0002893#ent", "<e1>", "SF", "CD14", "+", "monocytes", "also", "expressed", "B7RP.1", "(", "an", "C1705969#ent", "<e2>", "ligand", ")", "and", "the", "homologous", "ligand", ",", "identifying", "monocytes", "as", "potential", "mediators", "of", "antigen", "processing", "lymphocyte", "activation", "in", "C0002893#ent", "<e1>", "."], "h": {"id": "C0002893", "name": "C0002893#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [11, 12]}}
{"token": ["They", "were", "examined", "without", "knowledge", "of", "clinical", "disease", "the", "following", "characteristics", ":", "C0042384#ent", "<e1>", "erythrocyte", "extravasation", ",", "depth", "of", "infiltrate", "leukocytoclasis", ",", "fibrinoid", "necrosis", "C0014518#ent", "<e2>", "fibrin", "thrombi"], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014518", "name": "C0014518#ent", "pos": [24, 25]}}
{"token": ["Attachment", "of", "cultured", "cells", "tissue", "culture", "polystyrene", "C0628088#ent", "<e1>", ")", "is", "dependent", "on", "C1336937#ent", "<e2>", "which", "adsorbs", "onto", "the", "surface", "from", "the", "serum", "in", "the", "culture", "medium"], "h": {"id": "C0628088", "name": "C0628088#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336937", "name": "C1336937#ent", "pos": [13, 14]}}
{"token": ["Among", "the", "14", "human", "members", ",", "three", "are", "mutated", "in", "genetic", "diseases", "C0752282#ent", "<e1>", "two", "forms", "of", "C0393808#ent", "<e2>"], "h": {"id": "C0752282", "name": "C0752282#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0393808", "name": "C0393808#ent", "pos": [17, 18]}}
{"token": ["The", "amino", "acid", "sequences", "proteins", "HU-1", "and", "C1419743#ent", "<e1>", "are", "identical", "to", "those", "of", "proteins", "C0165193#ent", "<e2>", "and", "NS-2", "respectively", ",", "determined", "independently", "by", "Mende", "et", "al.", "[", "FEBS", "Lett", "."], "h": {"id": "C1419743", "name": "C1419743#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0165193", "name": "C0165193#ent", "pos": [15, 16]}}
{"token": ["C1539598#ent", "<e1>", "of", "mSin3A/Brm", ",", "chromatin", "remodeling", "and", "concomitant", "repression", "of", "endogenous", "C2976704#ent", "<e2>", "expression", "were", "impaired", "when", "SHP", "expression", "was", "inhibited", "by", "SHP", "small", "interfering", "RNA"], "h": {"id": "C1539598", "name": "C1539598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2976704", "name": "C2976704#ent", "pos": [12, 13]}}
{"token": ["In", "Ishikawa", "cells", ",", "oestradiol", "also", "increased", "C0017932#ent", "<e1>", "glycogen", "phosphorylase", "activities", ",", "while", "tamoxifen", "markedly", "suppressed", "these", "C3540790#ent", "<e2>", "."], "h": {"id": "C0017932", "name": "C0017932#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [18, 19]}}
{"token": ["After", "preincubation", "with", "ATP", ",", "the", "rate", "of", "phosphorylation", "of", "C0017932#ent", "<e1>", "the", "wild-type", "and", "Ala4", "C3540790#ent", "<e2>", "was", "inhibited", "by", "30%.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0017932", "name": "C0017932#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}}
{"token": ["Site-2", "of", "C0017932#ent", "<e1>", "preferentially", "phosphorylated", "by", "both", "C3540790#ent", "<e2>", ",", "followed", "by", "a", "slower", "phosphorylation", "of", "site-1b", "."], "h": {"id": "C0017932", "name": "C0017932#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [8, 9]}}
{"token": ["The", "inhibition", "of", "ganglionic", "transmission", "by", "fenoldopam", "both", "under", "in", "vivo", "in", "vitro", "was", "antagonized", "by", "R-sulpiride", "and", "C0025853#ent", "<e1>", ",", "but", "not", "by", "SCH", "23390", "S-sulpiride", "or", "C0031448#ent", "<e2>", "."], "h": {"id": "C0025853", "name": "C0025853#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [28, 29]}}
{"token": ["C0025853#ent", "<e1>", ",", "but", "not", "by", "C0031448#ent", "<e2>", ",", "suggesting", "that", "central", "dopamine", "receptors", "than", "alpha-adrenoceptors", "are", "involved", "in", "the", "mediation", "of", "the", "actions", "of", "dopamine", "in", "the", "brain", "."], "h": {"id": "C0025853", "name": "C0025853#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [6, 7]}}
{"token": ["Potent", "and", "selective", "tachykinin", "antagonists", "have", "therapeutic", "potential", "in", "C0006261#ent", "<e1>", "as", "asthma", "and", "C0008677#ent", "<e2>", "which", "neurogenic", "mucus", "hypersecretion", "may", "be", "aetiologically", "important", "."], "h": {"id": "C0006261", "name": "C0006261#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [14, 15]}}
{"token": ["Sarrat", "(", "1973", ")", "has", "shown", "the", "effectiveness", "of", "penicillin", "plus", "C0033209#ent", "<e1>", ",", "specti", "nomycin", "and", "cotrimoxazole", "in", "male", "cases", "of", "C0018081#ent", "<e2>", "in", "Dakar", "."], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [22, 23]}}
{"token": ["A", "double", "blind", "comparison", "of", "two", "regimens", "of", "amoxycillin", "plus", "C0033209#ent", "<e1>", "in", "the", "treatment", "of", "uncomplicated", "C0018081#ent", "<e2>", "reported", "."], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [17, 18]}}
{"token": ["The", "therapeutic", "efficacy", "a", "combination", "of", "a", "cephalosporin", "with", "C0033209#ent", "<e1>", "has", "been", "most", "thoroughly", "studied", "for", "single-dose", "treatment", "of", "C0018081#ent", "<e2>", "."], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [20, 21]}}
{"token": ["The", "eruptions", "improved", "with", "combination", "treatment", "oral", "C0032950#ent", "<e1>", "with", "cyclosporin", "A", "or", "C0010980#ent", "<e2>", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [13, 14]}}
{"token": ["Plasma", "exchange", "be", "more", "effective", "than", "the", "intravenous", "immunoglobulin", "the", "treatment", "of", "C0022972#ent", "<e1>", "crisis", "involving", "C1145670#ent", "<e2>"], "h": {"id": "C0022972", "name": "C0022972#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [16, 17]}}
{"token": ["Maternal", "aggravation", "or", "even", "C0022972#ent", "<e1>", "crisis", "with", "C1145670#ent", "<e2>", "can", "occur", "in", "the", "first", "three", "months", "post-partum", "."], "h": {"id": "C0022972", "name": "C0022972#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [8, 9]}}
{"token": ["At", "10(-5", ")", "M", "it", "antagonized", "the", "activity", "of", "beta-glucuronidase", "and", "C0007427#ent", "<e1>", "from", "the", "mouse", "macrophage", "as", "well", "as", "similar", "C3540790#ent", "<e2>", "secreted", "by", "rat", "macrophages", "in", "vivo"], "h": {"id": "C0007427", "name": "C0007427#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [21, 22]}}
{"token": ["C0007427#ent", "<e1>", "arylsulfatase", ",", "and", "acid", "phosphatase", "used", "as", "lysosomal", "marker", "C3540790#ent", "<e2>", "."], "h": {"id": "C0007427", "name": "C0007427#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["The", "double", "labeling", "procedures", "using", "two", "different", "combination", "of", "anti-acyl-CoA", "oxidase", "anti-beta-glucuronidase", "or", "anti-catalase", "and", "C0007427#ent", "<e1>", "that", "these", "C3540790#ent", "<e2>", "were", "simultaneously", "present", "in", "specific", "granules", "of", "the", "intestinal", "eosinophils"], "h": {"id": "C0007427", "name": "C0007427#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [19, 20]}}
{"token": ["These", "observations", "suggest", "that", "a", "chromatin-targeted", "repressor", "is", "present", "in", "crude", "extracts", "that", "C0008546#ent", "<e1>", "per", "se", "is", "not", "refractory", "to", "transcription", "mediated", "by", "C1705304#ent", "<e2>", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [24, 25]}}
{"token": ["Although", "C0403719#ent", "<e1>", "is", "a", "significant", "side", "effect", "C0700483#ent", "<e2>", "use", ",", "limiting", "its", "clinical", "application", "not", "the", "answer", "."], "h": {"id": "C0403719", "name": "C0403719#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0700483", "name": "C0700483#ent", "pos": [8, 9]}}
{"token": ["C0403719#ent", "<e1>", "in", "patients", "with", "AIDS", "may", "be", "caused", "by", "C0700483#ent", "<e2>", ",", "a", "protease", "inhibitor", "but", "the", "more", "common", "types", "of", "stones", "may", "also", "occur", "."], "h": {"id": "C0403719", "name": "C0403719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0700483", "name": "C0700483#ent", "pos": [10, 11]}}
{"token": ["We", "evaluated", "the", "radiographic", "characteristics", "as", "well", "as", "the", "clinical", "management", "C0403719#ent", "<e1>", "induced", "by", "systemic", "therapy", "C0700483#ent", "<e2>", "a", "protease", "inhibitor", "in", "the", "treatment", "of", "HIV", "infection"], "h": {"id": "C0403719", "name": "C0403719#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0700483", "name": "C0700483#ent", "pos": [17, 18]}}
{"token": ["In", "real-time", "quantitative", "reverse", "transcription-polymerase", "chain", "reaction", "RT-PCR", ")", "and", "reporter", "gene", "assays", "we", "show", "that", "C0021246#ent", "<e1>", "and", "aspirin", "upregulate", "C4255329#ent", "<e2>", "expression", "in", "MKN45", "gastric", "cells"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4255329", "name": "C4255329#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "C0021246#ent", "<e1>", "and", "aspirin", "upregulate", "gastric", "expression", "C4255329#ent", "<e2>", "through", "activation", "of", "PPARgamma", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4255329", "name": "C4255329#ent", "pos": [11, 12]}}
{"token": ["Novel", "cDNA", "clones", "with", "similarity", "to", "C1537985#ent", "<e1>", "salivary", "secreted", "protein", "actin", ",", "and", "a", "C1667078#ent", "<e2>", "induced", "after", "a", "blood", "meal"], "h": {"id": "C1537985", "name": "C1537985#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1667078", "name": "C1667078#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "report", "that", "ENT1-null", "mice", "show", "reduced", "hypnotic", "and", "C0234366#ent", "<e1>", "responses", "to", "ethanol", "and", "greater", "consumption", "of", "C0001962#ent", "<e2>", "as", "compared", "with", "their", "wild-type", "littermates", "."], "h": {"id": "C0234366", "name": "C0234366#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [19, 20]}}
{"token": ["Increased", "populations", "of", "interleukin", "1", "IL-1", ")", ",", "tumor", "necrosis", "factor", "alpha", "TNF-alpha", ")", ",", "interleukin", "6", "IL-6", ")", "and", "C1723257#ent", "<e1>", "(", "MMP-3", ")", "positive", "chondrocytes", "were", "found", "in", "C0029408#ent", "<e2>", "immunoperoxidase", "microscopy", "monospecific", "antibodies"], "h": {"id": "C1723257", "name": "C1723257#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [30, 31]}}
{"token": ["To", "determine", "whether", "plasma", "concentrations", "of", "C1723257#ent", "<e1>", "and", "gelatinase", "A", "increased", "in", "patients", "with", "various", "forms", "of", "C0029408#ent", "<e2>", "."], "h": {"id": "C1723257", "name": "C1723257#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [18, 19]}}
{"token": ["Induction", "of", "anaesthesia", "was", "carried", "out", "with", "C0013136#ent", "<e1>", ",", "phenoperidine", ",", "thiopentone", "and", "C0030311#ent", "<e2>", "."], "h": {"id": "C0013136", "name": "C0013136#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030311", "name": "C0030311#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "trypsin", "IV", "C3538773#ent", "<e1>", "are", "inhibitor-resistant", "trypsins", "that", "can", "cleave", "and", "activate", "C1414437#ent", "<e2>", ",", "causing", "PAR(1)-", "and", "PAR(2)-dependent", "inflammation", "and", "PAR(2)-dependent", "hyperalgesia", "."], "h": {"id": "C3538773", "name": "C3538773#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414437", "name": "C1414437#ent", "pos": [14, 15]}}
{"token": ["In", "study", "2", ",", "livers", "were", "stored", "for", "30", "hr", "in", "SLS", ",", "UW", ",", "UWm", ",", "and", "UWm", "+", "C0033229#ent", "<e1>", ",", "all", "without", "a", "C0040961#ent", "<e2>", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [26, 27]}}
{"token": ["Thus", ",", "in", "spite", "of", "our", "evolving", "understanding", "of", "this", "C0027765#ent", "<e1>", "in", "many", "cases", "complex", "C0458219#ent", "<e2>", "difficult", "to", "diagnose", "and", "treat", "successfully", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0458219", "name": "C0458219#ent", "pos": [16, 17]}}
{"token": ["Using", "immunoblot", "analyses", "we", "further", "demonstrate", "that", "doppel", "expression", "activates", "C0758959#ent", "<e1>", "as", "well", "as", "caspase-3", ",", "but", "does", "not", "activate", "C1705066#ent", "<e2>", "."], "h": {"id": "C0758959", "name": "C0758959#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705066", "name": "C1705066#ent", "pos": [21, 22]}}
{"token": ["A", "dissociated", "response", "of", "hematuria", "and", "proteinuria", "to", "C0003364#ent", "<e1>", "that", "MesPGN", "was", "coincidental", "with", "C1414406#ent", "<e2>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414406", "name": "C1414406#ent", "pos": [15, 16]}}
{"token": ["Pretreatment", "with", "the", "C0001641#ent", "<e1>", "phentolamine", "or", "the", "ganglion", "blocker", "C0030886#ent", "<e2>", "blocked", "the", "peak", "response", "reversed", "the", "more", "sustained", "response", "into", "a", "depressor", "effect"], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030886", "name": "C0030886#ent", "pos": [10, 11]}}
{"token": ["Inoculation", "of", "samples", "containing", "either", "prion-seeded", "or", "spontaneously", "generated", "PrP(Sc", ")", "molecules", "into", "hamsters", "caused", "C0074204#ent", "<e1>", ",", "which", "was", "C0009450#ent", "<e2>", "on", "second", "passage", "."], "h": {"id": "C0074204", "name": "C0074204#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [20, 21]}}
{"token": ["C0074204#ent", "<e1>", "is", "a", "C0009450#ent", "<e2>", "the", "central", "nervous", "system", "a", "slowly", "progressing", "but", "always", "fatal", "course", "."], "h": {"id": "C0074204", "name": "C0074204#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [4, 5]}}
{"token": ["We", "investigated", "whether", "previously", "described", "human", "C1367657#ent", "<e1>", "polymorphisms", "are", "associated", "with", "obesity", "and", "C0011849#ent", "<e2>", "in", "Korean", "subjects", "."], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}}
{"token": ["These", "data", "imply", "that", "the", "regulation", "of", "C0027203#ent", "<e1>", "potential", "is", "essential", "for", "any", "electron", "transfer", "substrate", "to", "C0027203#ent", "<e1>", "to", "occur", "in", "mammalian", "or", "C2936594#ent", "<e1>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2936594", "name": "C2936594#ent", "pos": [25, 26]}}
{"token": ["These", "results", "argue", "that", "photoreceptor", "differentiation", "is", "regulated", "by", "the", "C0525678#ent", "<e1>", "pathway", "through", "targeted", "proteolysis", "of", "the", "C1336689#ent", "<e2>", "repressor", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1336689", "name": "C1336689#ent", "pos": [18, 19]}}
{"token": ["This", "critical", "photoperiodic", "window", "of", "responsiveness", "to", "long", "days", "mammals", "is", "predicted", "by", "a", "model", "wherein", "C0001492#ent", "<e1>", "sensitization", "and", "C1413503#ent", "<e2>", "of", "melatonin", "combine", "to", "control", "neuroendocrine", "output", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413503", "name": "C1413503#ent", "pos": [20, 21]}}
{"token": ["These", "data", "demonstrate", "that", "the", "alpha", "subunit", "the", "C0752348#ent", "<e1>", "like", "tyrosine", "kinase", "growth", "factor", "receptors", "activates", "C0034678#ent", "<e2>", "and", "recruits", "a", "signal", "transduction", "pathway", "the", "small", "GTP-binding", "protein", "Rac", "that", "leads", "to", "JNK", "activation", "."], "h": {"id": "C0752348", "name": "C0752348#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [17, 18]}}
{"token": ["It", "is", "well", "documented", "that", "GPCR", "signalling", "through", "C0752348#ent", "<e1>", "lead", "to", "the", "activation", "of", "C0034678#ent", "<e2>", "and", "Rho", "GTPases"], "h": {"id": "C0752348", "name": "C0752348#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "Rgr", "reduced", "neurite", "outgrowth", "induced", "by", "a", "mutant", "C0220304#ent", "<e1>", "preferentially", "activates", "C0104940#ent", "<e2>"], "h": {"id": "C0220304", "name": "C0220304#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0104940", "name": "C0104940#ent", "pos": [15, 16]}}
{"token": ["The", "amino", "acid", "sequence", "from", "the", "nucleotide", "sequence", "the", "cDNAs", "showed", "similarity", "to", "regions", "of", "previously", "sequenced", "biotin", "C3540790#ent", "<e1>", ",", "indicating", "that", "the", "isolated", "cDNAs", "code", "a", "C1531135#ent", "<e2>"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1531135", "name": "C1531135#ent", "pos": [28, 29]}}
{"token": ["Specific", "high-affinity", "insulin", "and", "insulin-like", "growth", "factor", "I", "C1334089#ent", "<e1>", ")", "binding", ",", "glucose", "transporter", "proteins", "GLUT1", "and", "GLUT4", ",", "glycogen", "synthase", "C0034343#ent", "<e2>", "and", "their", "specific", "mRNAs", "were", "identified", "in", "fused", "myotubes", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034343", "name": "C0034343#ent", "pos": [22, 23]}}
{"token": ["We", "now", "demonstrate", "that", "C0020456#ent", "<e1>", "induces", "activation", "of", "sphingosine", "kinase", "C1420357#ent", "<e2>", ")", ",", "which", "represents", "a", "novel", "signaling", "pathway", "mediates", "endothelial", "damage", "ambient", "high", "glucose", "conditions", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420357", "name": "C1420357#ent", "pos": [11, 12]}}
{"token": ["The", "strong", "inverse", "relation", "between", "HDL", "and", "C1956346#ent", "<e1>", "believed", "to", "be", "most", "closely", "related", "to", "the", "C1847987#ent", "<e2>", "subfraction", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1847987", "name": "C1847987#ent", "pos": [17, 18]}}
{"token": ["In", "our", "present", "studies", ",", "naphthalene", "biodegradation", "C0812445#ent", "<e1>", "was", "slow", "or", "nearly", "absent", "when", "C0000975#ent", "<e2>", "was", "not", "present", ",", "suggesting", "a", "stimulating", "effect", "by", "the", "non-fermentable", "substrate", "."], "h": {"id": "C0812445", "name": "C0812445#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [15, 16]}}
{"token": ["C0949656#ent", "<e1>", "a", "substrate", "for", "the", "C1417582#ent", "<e2>", "holoenzyme", ",", "but", "the", "Z-line", "location", "raises", "the", "possibility", "of", "other", "substrates", "."], "h": {"id": "C0949656", "name": "C0949656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417582", "name": "C1417582#ent", "pos": [6, 7]}}
{"token": ["In", "conclusion", ",", "C0005943#ent", "<e1>", "a", "major", "cause", "of", "mortality", "in", "patients", "with", "C1442905#ent", "<e2>", "."], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1442905", "name": "C1442905#ent", "pos": [13, 14]}}
{"token": ["DNA", "sequence", "specificities", "of", "C0955176#ent", "<e1>", ",", "genistein", ",", "piroxantrone", "and", "C0115685#ent", "<e2>", "were", "determined", "by", "using", "simian", "virus", "40", "DNA", "compared", "to", "those", "of", "mitoxantrone", ",", "4-demethoxydaunorubicin", ",", "VM-26", "and", "mAMSA", "."], "h": {"id": "C0955176", "name": "C0955176#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0115685", "name": "C0115685#ent", "pos": [11, 12]}}
{"token": ["Glutathione", "(", "GSH", ")", ",", "glutathione", "S-transferases", "C1865138#ent", "<e1>", ")", ",", "and", "the", "C0919458#ent", "<e2>", "MRP1", ")", "have", "been", "independently", "studied", "for", "their", "contributions", "to", "drug", "resistance"], "h": {"id": "C1865138", "name": "C1865138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0919458", "name": "C0919458#ent", "pos": [13, 14]}}
{"token": ["The", "strains", "were", "grouped", "into", "35", "C0812380#ent", "<e1>", "constituting", "three", "main", "divisions", "(", "I", ",", "C3273406#ent", "<e2>", ",", "and", "III", ")", "separated", "at", "a", "genetic", "distance", "than", "0.75", "."], "h": {"id": "C0812380", "name": "C0812380#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [15, 16]}}
{"token": ["The", "deduced", "amino", "acid", "sequences", "2D-1", ",", "2D-19", ",", "2D-24", ",", "and", "C1823694#ent", "<e1>", "had", "a", "homology", "with", "mammalian", "C1334523#ent", "<e2>", ",", "MMP3/10", ",", "MMP3/10", ",", "and", "MMP13", ",", "respectively", "."], "h": {"id": "C1823694", "name": "C1823694#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334523", "name": "C1334523#ent", "pos": [19, 20]}}
{"token": ["We", "show", "that", "C1424233#ent", "<e1>", "is", "an", "endoplasmic", "reticulum", "ER", ")", "C0021699#ent", "<e2>", "a", "transmembrane", "domain", "the", "amino", "terminus", "and", "the", "catalytic", "domain", "the", "cytoplasm", "."], "h": {"id": "C1424233", "name": "C1424233#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [11, 12]}}
{"token": ["In", "the", "treatment", "of", "C0001327#ent", "<e1>", "vocal", "cord", "nodules", "polyps", "or", "C0472519#ent", "<e2>", "all", "the", "stated", "adverse", "factors", "should", "be", "identified", "and", "suitably", "diminished", "or", "eliminated", "."], "h": {"id": "C0001327", "name": "C0001327#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0472519", "name": "C0472519#ent", "pos": [11, 12]}}
{"token": ["The", "C0206256#ent", "<e1>", "bICP0", ",", "of", "Bovine", "herpesvirus", "1", "BHV-1", ")", "transactivates", "viral", "promoters", "stimulates", "C2314882#ent", "<e2>"], "h": {"id": "C0206256", "name": "C0206256#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [15, 16]}}
{"token": ["A", "standard", "NSAID", "plus", "a", "C3536754#ent", "<e1>", "be", "equally", "effective", "as", "a", "C1565860#ent", "<e2>", "inhibitor", "in", "reducing", "the", "risk", "of", "gastroduodenal", "toxicity", "and", "if", "used", "the", "same", "prescribing", "advice", "applies", "."], "h": {"id": "C3536754", "name": "C3536754#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [12, 13]}}
{"token": ["Whereas", "the", "intracellular", "isoenzymes", "were", "both", "C0907533#ent", "<e1>", "and", "inducible", ",", "apoplastic", "GST", "and", "C0017822#ent", "<e2>", "detectable", "only", "in", "tissues", "treated", "with", "known", "GST", "inducer", "2,3,5-triiodobenzoic", "acid"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017822", "name": "C0017822#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "we", "demonstrate", "that", ",", "like", "the", "N-", "and", "C0079068#ent", "<e1>", "genes", ",", "the", "L-myc", "gene", "cooperate", "with", "a", "mutant", "C0079472#ent", "<e2>", "cause", "malignant", "transformation", "of", "rat", "embryo", "fibroblasts", "in", "culture", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079472", "name": "C0079472#ent", "pos": [21, 22]}}
{"token": ["C0080151#ent", "<e1>", "inhibit", "synthesis", "of", "C3540754#ent", "<e2>", ",", "which", "are", "fringe", "players", "in", "the", "inflammatory", "process"], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [5, 6]}}
{"token": ["In", "disease", "states", "as", "C0010346#ent", "<e1>", "inhibition", "of", "myocyte", "proliferation", "VIP", "and", "C1412228#ent", "<e2>", "may", "serve", "to", "control", "smooth", "muscle", "hyperplasia", "the", "colon", "but", "not", "in", "the", "antrum", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [12, 13]}}
{"token": ["C0025872#ent", "<e1>", "is", "therefore", "suggested", "as", "a", "drug", "of", "choice", "for", "C0017536#ent", "<e2>"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0017536", "name": "C0017536#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "ubiquitinated", "species", "of", "histones", "C1415407#ent", "<e1>", "and", "H2B", "and", "hyperacetylated", "species", "of", "C1425774#ent", "<e2>", "and", "H2B", ",", "which", "are", "complexed", "to", "active", "DNA", "are", "labelled", "."], "h": {"id": "C1415407", "name": "C1415407#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1425774", "name": "C1425774#ent", "pos": [14, 15]}}
{"token": ["We", "suggest", "that", "the", "histones", "can", "be", "divided", "into", "three", "groups", "with", "decreasing", "hydrophobic", "properties", ":", "H3", ",", "C1415407#ent", "<e1>", "greater", "than", "C1425774#ent", "<e2>", ",", "H2b", "greater", "than", "H1", "."], "h": {"id": "C1415407", "name": "C1415407#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1425774", "name": "C1425774#ent", "pos": [22, 23]}}
{"token": ["It", "is", "of", "interest", "that", "the", "3", "C0040156#ent", "<e1>", "patients", "were", "C1421143#ent", "<e2>", "hyporesponders", "at", "their", "first", "visit", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [11, 12]}}
{"token": ["It", "would", "appear", "that", "clinically", "occult", "C0040156#ent", "<e1>", "can", "be", "identified", "consistently", "only", "with", "the", "C1421143#ent", "<e2>", "is", "the", "cause", "of", "\"", "idiopathic", "\"", "atrial", "fibrillation", "a", "significant", "proportion", "of", "patients", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [15, 16]}}
{"token": ["C0812288#ent", "<e1>", "showed", "a", "marked", "decrease", "in", "H1", "and", "C0919509#ent", "<e2>", "compared", "with", "N.", "Hb", "was", "positively", "related", "to", "C0812288#ent", "<e1>", "in", "hypoxia", "."], "h": {"id": "C0812288", "name": "C0812288#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [9, 10]}}
{"token": ["After", "excision", "of", "the", "C0085648#ent", "<e1>", "and", "decompression", "of", "the", "posterior", "interosseous", "nerve", "the", "C0271375#ent", "<e2>", "completely", "in", "all", "cases", "."], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0271375", "name": "C0271375#ent", "pos": [14, 15]}}
{"token": ["The", "purpose", "of", "the", "present", "study", "was", "to", "evaluate", "the", "effects", "of", "C0126174#ent", "<e1>", "and", "the", "combination", "of", "C0126174#ent", "<e1>", "and", "L-arginine", "on", "endothelial", "function", "hemodynamic", "variables", "in", "patients", "with", "C0018801#ent", "<e1>", "HF", ")", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [30, 31]}}
{"token": ["However", ",", "the", "effect", "of", "C0126174#ent", "<e1>", "on", "TNFalpha", "levels", "in", "C0018801#ent", "<e2>", "not", "yet", "been", "studied", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}}
{"token": ["Since", "myocardial", "dysfunction", "frequently", "associated", "with", "impaired", "energy", "status", "the", "aim", "of", "this", "study", "was", "to", "assess", "the", "effects", "of", "exercise", "training", "and", "C0126174#ent", "<e1>", "on", "myocardial", "systems", "energy", "production", "transfer", "in", "C0018801#ent", "<e2>"], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [32, 33]}}
{"token": ["Heparin/heparan-sulfate", "proteoglycan", "C2987155#ent", "<e1>", ")", "binds", "to", "heparin-binding", "epidermal", "growth", "factor-like", "growth", "factor", "HB-EGF", ")", "through", "its", "C1332127#ent", "<e2>", "HBD", ")", ",", "which", "consists", "of", "21", "amino", "acid", "residues", "(", "P21", ")", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332127", "name": "C1332127#ent", "pos": [17, 18]}}
{"token": ["No", "interferences", "were", "found", "in", "the", "assay", "of", "ethosuximide", ",", "phenobarbital", ",", "phenytoin", ",", "C0042291#ent", "<e1>", "digitoxin", ",", "digoxin", ",", "C0033216#ent", "<e2>", ",", "gentamicin", "and", "theophylline", "."], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [20, 21]}}
{"token": ["Concentrations", "of", "digoxin", ",", "tricyclic", "antidepressants", "TCAs", ")", ",", "phenytoin", ",", "carbamazepine", ",", "theophylline", ",", "C0042291#ent", "<e1>", "quinidine", ",", "phenobarbital", ",", "C0033216#ent", "<e2>", ",", "and", "N-acetyl", "procainamide", "measured", "in", "serum", "."], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "the", "interaction", "of", "C1418392#ent", "<e1>", "with", "the", "C1420216#ent", "<e2>", "the", "intestinal", "cell", "membrane", "the", "cause", "of", "the", "reduced", "taurine", "uptake", "."], "h": {"id": "C1418392", "name": "C1418392#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420216", "name": "C1420216#ent", "pos": [11, 12]}}
{"token": ["As", "expected", ",", "increases", "in", "hepatic", "free", "cholesterol", "are", "associated", "with", "decreases", "in", "C0020374#ent", "<e1>", "increases", "in", "C1412058#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0020374", "name": "C0020374#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412058", "name": "C1412058#ent", "pos": [17, 18]}}
{"token": ["Four", "of", "the", "C0019693#ent", "<e1>", "X-linked", "agammaglobulinemia", "X-linked", "severe", "combined", "immunodeficiency", "SCID", ")", ",", "Wiskott-Aldrich", "syndrome", "and", "C1844376#ent", "<e2>", "affect", "cellular", "development", "that", "carriers", "have", "a", "monomorphic", "population", "of", "immunocytes", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1844376", "name": "C1844376#ent", "pos": [17, 18]}}
{"token": ["Examples", "of", "these", "important", "C0086376#ent", "<e1>", "include", "the", "tumor", "suppressor", "protein", "p53", "various", "cyclins", ",", "the", "C1511576#ent", "<e2>", "p27", ",", "NFkappaB", ",", "IkappaB", ",", "c-fos", ",", "and", "c-jun", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1511576", "name": "C1511576#ent", "pos": [16, 17]}}
{"token": ["Assessment", "of", "protein", "levels", "cyclin", "D1", "cyclin", "E", "Western", "blots", "pronounced", "increases", "of", "both", "C0086376#ent", "<e1>", "in", "each", "pulmonary", "adenocarcinoma", "cell", "line", "whereas", "protein", "levels", "C1511576#ent", "<e2>", "p21", "remained", "unchanged", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1511576", "name": "C1511576#ent", "pos": [25, 26]}}
{"token": ["Blood", "and", "a", "variety", "of", "tissues", "from", "97", "patients", "with", "the", "C0001175#ent", "<e1>", "AIDS", ")", "and", "25", "with", "the", "AIDS", "C0240805#ent", "<e2>", "were", "studied", "ultrastructurally", "."], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0240805", "name": "C0240805#ent", "pos": [20, 21]}}
{"token": ["Supernatants", "derived", "from", "peripheral", "blood", "mononuclear", "cell", "cultures", "certain", "patients", "with", "the", "C0001175#ent", "<e1>", "AIDS", ")", "or", "its", "C0240805#ent", "<e2>", "have", "the", "capacity", "to", "block", "T", "immune", "reactivity", "in", "vitro"], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0240805", "name": "C0240805#ent", "pos": [18, 19]}}
{"token": ["The", "C0030946#ent", "<e1>", "was", "strongly", "inhibited", "by", "phenylmethylsulfonylfluoride", ",", "C0035100#ent", "<e2>", "and", "antipain", ",", "but", "not", "by", "chelators", ",", "sulfhydryl-reactive", "agents", "trypsin", "inhibitors"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035100", "name": "C0035100#ent", "pos": [9, 10]}}
{"token": ["C3538129#ent", "<e1>", ",", "a", "transformed", "avian", "C1522428#ent", "<e2>", "and", "chicken", "peripheral", "blood", "leukocyte-derived", "macrophages", "PBL-M", "phi", ")", "were", "stimulated", "with", "bacterial", "endotoxin", "lipopolysaccharide", "LPS", ")", "or", "Eimeria", "tenella", "sporozoites", "and", "merozoites", "."], "h": {"id": "C3538129", "name": "C3538129#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [6, 7]}}
{"token": ["C0118168#ent", "<e1>", "treatment", "consistently", "increased", "exercise", "duration", "and", "improved", "C0018801#ent", "<e2>", "symptoms", "in", "these", "patients", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [9, 10]}}
{"token": ["C0118168#ent", "<e1>", "was", "well", "tolerated", "in", "clinical", "trials", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [10, 11]}}
{"token": ["The", "S-8", "and", "intact", "C0039902#ent", "<e1>", "had", "nearly", "identical", "C2917660#ent", "<e2>", "compositions", "with", "differences", "only", "in", "glutamic", "acid", "glycine", "and", "proline", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [9, 10]}}
{"token": ["Therefore", ",", "we", "have", "studied", "the", "role", "of", "normal", "(", "Fli-1", "and", "C0599295#ent", "<e1>", ")", "and", "aberrant", "fusion", "proteins", "C1851465#ent", "<e2>", ",", "EWS-Fli-1", "and", "TLS/FUS-erg", ")", "in", "apoptosis", "."], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [12, 13]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1851465", "name": "C1851465#ent", "pos": [19, 20]}}
{"token": ["The", "level", "of", "C0020433#ent", "<e1>", "attained", "was", "not", "influenced", "by", "fasting", "or", "C0031412#ent", "<e2>", ",", "and", "returned", "to", "baseline", "concentration", "within", "10", "days", "of", "resuming", "a", "normal", "diet"], "h": {"id": "C0020433", "name": "C0020433#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [12, 13]}}
{"token": ["Patients", "with", "EF", "less", "than", "or", "equal", "to", "45", "%", ",", "high", "C1414063#ent", "<e1>", "and", "LVDD", "had", "the", "highest", "plasma", "C1417807#ent", "<e2>", "and", "showed", "steady", "high", "plasma", "C1417807#ent", "<e2>", "for", "15", "days", "."], "h": {"id": "C1414063", "name": "C1414063#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [20, 21]}}
{"token": ["Taken", "together", "these", "observations", "indicate", "that", "the", "cytoplasmic", "domain", "the", "PRL", "receptor", "with", "one", "or", "several", "C0033681#ent", "<e1>", "which", "may", "represent", "early", "postreceptor", "events", "necessary", "for", "C1418938#ent", "<e2>", "signal", "transduction", "milk", "protein", "genes"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [26, 27]}}
{"token": ["Tako-tsubo-like", "left", "ventricular", "dysfunction", "phenomenon", "(", "TTP", ")", "is", "characterized", "by", "transient", "C1739395#ent", "<e1>", "associated", "with", "symptoms", ",", "electrocardiographic", "changes", "minimal", "C0443763#ent", "<e2>", "release", "in", "the", "absence", "of", "coronary", "artery", "disease"], "h": {"id": "C1739395", "name": "C1739395#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0443763", "name": "C0443763#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "it", "appears", "that", "the", "biogenesis", "of", "two", "C1423524#ent", "<e1>", "cytochrome", "c", "cytochrome", "c", "oxidase", "in", "the", "C0171406#ent", "<e2>", "are", "under", "the", "control", "of", "common", "factors", "."], "h": {"id": "C1423524", "name": "C1423524#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [18, 19]}}
{"token": ["Three", "synthetic", "peptides", "from", "the", "amino", "terminal", "region", "alpha", "gliadin", "were", "used", "as", "immobilized", "antigens", "for", "AG", ",", "and", "the", "C0033679#ent", "<e1>", "from", "guinea", "pig", "C0023899#ent", "<e2>", "for", "AE", "."], "h": {"id": "C0033679", "name": "C0033679#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [25, 26]}}
{"token": ["Rat", "pancreatic", "islets", "a", "Ca2", "+", "-activated", "and", "C0033679#ent", "<e1>", "EC", "2.3.2.13", "comparable", "in", "activity", "with", "that", "found", "in", "rat", "C0023899#ent", "<e2>", ",", "lung", "and", "spleen", "."], "h": {"id": "C0033679", "name": "C0033679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [20, 21]}}
{"token": ["In", "agreement", ",", "in", "PF", "NK", "cells", "observed", "an", "increased", "expression", "of", "CD94", ",", "NKG2A", ",", "C1335808#ent", "<e1>", ",", "and", "CCR7", "molecules", "and", "lower", "expression", "of", "C1704467#ent", "<e2>", "and", "perforin", "."], "h": {"id": "C1335808", "name": "C1335808#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [26, 27]}}
{"token": ["Benzimidazole", "carbamate", "derivatives", "as", "C0025023#ent", "<e1>", "and", "albendazole", "are", "currently", "used", "for", "C0003392#ent", "<e2>", "AE", "."], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [12, 13]}}
{"token": ["Benzimidazole", "carbamate", "derivatives", "as", "C0025023#ent", "<e1>", "and", "albendazole", "are", "used", "for", "C0003392#ent", "<e2>", "AE", "."], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [11, 12]}}
{"token": ["We", "have", "demonstrated", "that", "the", "C0072522#ent", "<e1>", "upregulated", "by", "C0002842#ent", "<e2>", "and", "is", "affected", "by", "neither", "epidermal", "growth", "factor", "basic", "fibroblast", "growth", "factor"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [9, 10]}}
{"token": ["The", "decline", "in", "C0072522#ent", "<e1>", "levels", "postoperatively", "implies", "that", "C0072522#ent", "<e1>", "expression", "is", "controlled", "by", "C0002842#ent", "<e1>", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [15, 16]}}
{"token": ["Indirect", "evidence", "indicates", "that", "the", "C0072522#ent", "<e1>", "be", "regulated", "by", "C0002842#ent", "<e2>", ",", "and", "previous", "studies", "in", "this", "laboratory", "have", "demonstrated", "that", "PSA", "mRNA", "is", "upregulated", "by", "C0002842#ent", "<e2>", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [10, 11]}}
{"token": ["These", "measurements", "must", "be", "combined", "with", "other", "techniques", "such", "as", "extracranial", "Doppler", "C1428360#ent", "<e1>", "to", "assess", "the", "degree", "of", "C0037763#ent", "<e2>", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0037763", "name": "C0037763#ent", "pos": [19, 20]}}
{"token": ["Five", "patients", "with", "immune", "thrombocytopenia", "C0027947#ent", "<e1>", ",", "including", "three", "with", "C0002880#ent", "<e2>", "are", "described", ";", "none", "had", "identifiable", "underlying", "disease", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002880", "name": "C0002880#ent", "pos": [11, 12]}}
{"token": ["NCoR/SMRT", "are", "responsible", "for", "recruitment", "of", "C1333891#ent", "<e1>", "HDACs", ")", ",", "which", "is", "required", "for", "transcriptional", "repression", "C3887967#ent", "<e2>", "target", "genes", ",", "and", "for", "the", "transforming", "potential", "of", "the", "fusion", "protein"], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3887967", "name": "C3887967#ent", "pos": [17, 18]}}
{"token": ["This", "particular", "alphabeta", "T", "lymphocyte", "has", "the", "morphology", "of", "large", "granular", "lymphocytes", ",", "increases", "proportionately", "in", "vivo", "C0024282#ent", "<e1>", "and", "can", "be", "detected", "in", "vitro", "C1879348#ent", "<e2>", "stimulation", "with", "EBV", "Ags", "."], "h": {"id": "C0024282", "name": "C0024282#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1879348", "name": "C1879348#ent", "pos": [25, 26]}}
{"token": ["The", "assay", "allows", "high-throughput", "analysis", ",", "critically", ",", "also", "ensures", "a", "high", "level", "of", "C0027203#ent", "<e1>", "specificity", "even", "when", "assaying", "crude", "tissue", "homogenates", "or", "C3889436#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [24, 25]}}
{"token": ["Hyponatraemia", "was", "found", "in", "five", "of", "the", "C0012191#ent", "<e1>", "patients", "and", "C0268005#ent", "<e2>", "in", "six", "."], "h": {"id": "C0012191", "name": "C0012191#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268005", "name": "C0268005#ent", "pos": [11, 12]}}
{"token": ["Jia", "Wei", "Cang", "Er", "Zi", "San", ",", "a", "traditional", "C4287688#ent", "<e1>", "has", "been", "used", "to", "treat", "C2607914#ent", "<e2>", "AR", ")", "for", "several", "centuries", "."], "h": {"id": "C4287688", "name": "C4287688#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2607914", "name": "C2607914#ent", "pos": [16, 17]}}
{"token": ["Treatment", "of", "acute", "exacerbations", "C0009324#ent", "<e1>", "and", "CD", "is", "essentially", "conservative", "and", "consists", "of", "C0036078#ent", "<e2>", "or", "5-aminosalicylic", "acid", "prednisone", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [14, 15]}}
{"token": ["The", "histidine", "tag", "removed", "from", "the", "human", "C0014442#ent", "<e1>", "by", "thrombin", "digestion", "the", "C1412262#ent", "<e2>", "purified", "by", "Sephadex", "G-100", "gel", "filtration", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412262", "name": "C1412262#ent", "pos": [13, 14]}}
{"token": ["These", "novel", "analogs", "of", "adenylosuccinate", "were", "synthesized", "with", "this", "C0014442#ent", "<e1>", "and", "their", "kinetic", "constants", "were", "determined", "with", "C1412262#ent", "<e2>", "purified", "from", "Ehrlich", "ascites", "cells"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412262", "name": "C1412262#ent", "pos": [18, 19]}}
{"token": ["Relatively", "large", "ligands", "(", "e.g.", ",", "norharman", ")", "which", "do", "not", "readily", "form", "complexes", "with", "myoglobin", "and", "horseradish", "peroxidase", "C1420727#ent", "<e1>", ")", "can", "bind", "to", "the", "C1564138#ent", "<e2>", "."], "h": {"id": "C1420727", "name": "C1420727#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1564138", "name": "C1564138#ent", "pos": [26, 27]}}
{"token": ["Treatment", "with", "C3539185#ent", "<e1>", "may", "also", "contribute", "to", "the", "accelerated", "C0004153#ent", "<e2>", "observed", "in", "these", "patients", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [10, 11]}}
{"token": ["Systemic", "effects", "two", "topical", "B", "adrenergic", "blocking", "agents", "C0543450#ent", "<e1>", "and", "metipranolol", ",", "recently", "introduced", "in", "the", "treatment", "of", "C0017612#ent", "<e2>", "were", "investigated", "in", "two", "groups", "of", "10", "asthmatic", "patients", ",", "according", "to", "a", "controlled", "trial", "device"], "h": {"id": "C0543450", "name": "C0543450#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [19, 20]}}
{"token": ["In", "a", "3-month", ",", "double-masked", ",", "randomized", "clinical", "trial", "the", "ocular", "hypotensive", "efficacy", "systemic", "safety", "0.5", "%", "levobunolol", "and", "2", "%", "C0543450#ent", "<e1>", "were", "compared", "in", "59", "patients", "with", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0543450", "name": "C0543450#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [29, 30]}}
{"token": ["However", ",", "C1419385#ent", "<e1>", "also", "affect", "microtubules", "(", "C0796074#ent", "<e2>", ")", "."], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [8, 9]}}
{"token": ["The", "rumen-protected", "C1822773#ent", "<e1>", "tended", "to", "increase", "both", "the", "crude", "protein", "and", "C0007332#ent", "<e2>", "content", "of", "milk", "."], "h": {"id": "C1822773", "name": "C1822773#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [12, 13]}}
{"token": ["In", "cases", "of", "histologically", "less", "severe", "C0563238#ent", "<e1>", "as", "a", "rule", ",", "C0014442#ent", "<e2>", "histochemical", "changes", "were", "not", "found", "."], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["The", "long-acting", "beta2-agonist", "(", "LABA", ")", "C0060657#ent", "<e1>", "has", "an", "onset", "of", "effect", "comparable", "to", "that", "of", "C0001927#ent", "<e2>", "."], "h": {"id": "C0060657", "name": "C0060657#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [17, 18]}}
{"token": ["The", "effectiveness", "of", "C0002934#ent", "<e1>", "improved", "by", "the", "addition", "of", "a", "C4255305#ent", "<e2>", "with", "an", "increased", "duration", "of", "action", "and", "the", "ability", "to", "decrease", "both", "systemic", "toxic", "reactions", "local", "bleeding"], "h": {"id": "C0002934", "name": "C0002934#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [11, 12]}}
{"token": ["The", "effectiveness", "of", "C0002934#ent", "<e1>", "improved", "by", "the", "addition", "of", "a", "C4255305#ent", "<e2>", "which", "increases", "duration", "of", "action", "and", "decreases", "both", "systemic", "toxic", "reactions", "local", "bleeding"], "h": {"id": "C0002934", "name": "C0002934#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [11, 12]}}
{"token": ["The", "diarrhea", "score", "worse", "between", "one", "and", "two", "years", "after", "the", "transplantation", "and", "was", "closely", "related", "to", "the", "C0720099#ent", "<e1>", "of", "the", "C0426576#ent", "<e2>", "to", "the", "C0720099#ent", "<e1>", "of", "the", "disease", "before", "transplantation", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [22, 23]}}
{"token": ["Acupoint", "stimulation", "no", "effect", "on", "basal", "LES", "pressure", ",", "the", "residual", "LES", "pressure", "TLESRs", ",", "the", "C0720099#ent", "<e1>", "of", "TLESRs", ",", "or", "C0426576#ent", "<e2>", "fullness", ",", "bloating", ",", "discomfort", ",", "or", "nausea", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [22, 23]}}
{"token": ["Flunarizine", "decreases", "the", "frequency", "and", "C0720099#ent", "<e1>", "of", "migrainous", "episodes", "as", "well", "as", "the", "C0426576#ent", "<e2>"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [14, 15]}}
{"token": ["Since", "many", "studies", "have", "shown", "that", "the", "c-myc", "C1417123#ent", "<e1>", "is", "involved", "in", "cell", "proliferation", "differentiation", ",", "the", "effect", "of", "C1522428#ent", "<e2>", "c-myc", "messenger", "RNA", "mRNA", ")", "level", "in", "HPLF", "was", "examined", "."], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [20, 21]}}
{"token": ["We", "chose", "to", "evaluate", "immunologic", "function", "C0019693#ent", "<e1>", "negative", "patients", "who", "received", "C0886530#ent", "<e2>", "and", "Combivir", "(", "AZT", "and", "3TC", ")", "as", "PEP", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0886530", "name": "C0886530#ent", "pos": [12, 13]}}
{"token": ["ASUR4", "is", "the", "Xenopus", "laevis", "homologue", "human", "C3811108#ent", "<e1>", "and", "rat", "C1420369#ent", "<e2>", ",", "a", "membrane", "protein", "related", "to", "yeast", "and", "prokaryotic", "permeases", "and", "ASUR5", "is", "the", "A", "transcript", "of", "Xenopus", "K-ras2", "."], "h": {"id": "C3811108", "name": "C3811108#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [11, 12]}}
{"token": ["C3811108#ent", "<e1>", "also", "corresponds", "to", "tumor-associated", "gene-1", "C1420369#ent", "<e2>", ")", ",", "an", "oncofetal", "antigen", "is", "expressed", "primarily", "in", "fetal", "tissues", "cancer", "cells", "as", "glioma", "cells"], "h": {"id": "C3811108", "name": "C3811108#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [7, 8]}}
{"token": ["The", "sequence", "of", "human", "Oct3A", "shows", "87", "%", "C2917660#ent", "<e1>", "with", "mouse", "C1420138#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420138", "name": "C1420138#ent", "pos": [12, 13]}}
{"token": ["Our", "data", "show", "that", "C3274761#ent", "<e1>", "preferentially", "binds", "to", "the", "nonphosphorylated", "isoforms", "of", "C1854469#ent", "<e2>", "."], "h": {"id": "C3274761", "name": "C3274761#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1854469", "name": "C1854469#ent", "pos": [13, 14]}}
{"token": ["C1417172#ent", "<e1>", "isoforms", "regulated", "TGF-beta1-induced", "transcription", "of", "C1705527#ent", "<e2>", "differently", ";", "MITF-E-mediated", "transcription", "was", "further", "increased", "by", "TGF-beta1", ",", "whereas", "transcriptional", "activation", "TGF-beta1", "was", "blocked", "by", "MITF-M", "or", "MITF-mc", "expression", "."], "h": {"id": "C1417172", "name": "C1417172#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705527", "name": "C1705527#ent", "pos": [7, 8]}}
{"token": ["Daily", "administration", "of", "bovine", "Cu-Zn", "superoxide", "dismutase", "conjugated", "with", "C0032483#ent", "<e1>", "the", "serum", "level", "alterations", "and", "C0267953#ent", "<e2>", "indicating", "that", "the", "superoxide", "radical", "a", "role", "in", "dietary", "carbohydrate-induced", "acute", "pancreatitis", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0267953", "name": "C0267953#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "we", "report", "a", "slight", "action", "of", "C0755322#ent", "<e1>", "on", "Tyr-716", ",", "which", "directs", "MAPK", "activation", "through", "C1333707#ent", "<e2>", "binding", "."], "h": {"id": "C0755322", "name": "C0755322#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333707", "name": "C1333707#ent", "pos": [19, 20]}}
{"token": ["The", "disease", "is", "characterized", "by", "the", "triad", "of", "necrotizing", "granulomatous", "of", "the", "respiratory", "tract", "C0553548#ent", "<e1>", "arteries", "and", "veins", ",", "and", "C0238124#ent", "<e2>", "terminating", "in", "uremia", "."], "h": {"id": "C0553548", "name": "C0553548#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0238124", "name": "C0238124#ent", "pos": [21, 22]}}
{"token": ["Clotrimazole", "is", "the", "C0013227#ent", "<e1>", "of", "choice", "for", "Aspergillus", "species", "miconazole", "and", "C0546862#ent", "<e2>", "are", "more", "effective", "with", "some", "isolates", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0546862", "name": "C0546862#ent", "pos": [12, 13]}}
{"token": ["C3274829#ent", "<e1>", "consist", "of", "protein", "with", "some", "C0032594#ent", "<e2>", ";", "ASG", "are", "composed", "of", "protein", "carbohydrate", "complexes", "lack", "catecholamines", ";", "ICG", "contain", "catecholamine", "as", "well", "as", "protein", "carbohydrate", "complexes"], "h": {"id": "C3274829", "name": "C3274829#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [7, 8]}}
{"token": ["Here", "we", "report", "that", "C1417953#ent", "<e1>", "reflects", "the", "expression", "of", "escargot", "(", "C1420753#ent", "<e2>", ")", ",", "a", "member", "of", "the", "snail", "gene", "family", "which", "are", "transcription", "factors", "zink", "finger", "motifs"], "h": {"id": "C1417953", "name": "C1417953#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420753", "name": "C1420753#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "that", "C1382029#ent", "<e1>", "regulate", "Cl-", "permeability", "of", "the", "endolymph-perilymph", "barrier", "and", "that", "C1382029#ent", "<e1>", "a", "critical", "role", "in", "acute", "endolymphatic", "hydrops", "Meniere's", "disease", "C2712370#ent", "<e1>", "the", "osmolarity", "of", "the", "endolymph", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [26, 27]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "evaluate", "the", "clinical", "applicability", "of", "serum", "eosinophil", "cationic", "protein", "ECP", ")", ",", "interleukin-5", "(", "IL-5", ")", "and", "total", "C0014457#ent", "<e1>", "counts", "in", "childhood", "asthma", "C0006271#ent", "<e2>", "."], "h": {"id": "C0014457", "name": "C0014457#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0006271", "name": "C0006271#ent", "pos": [31, 32]}}
{"token": ["These", "data", "suggest", "that", "C0014457#ent", "<e1>", "degranulation", "in", "the", "respiratory", "tract", "during", "C0006271#ent", "<e2>", "may", "play", "a", "significant", "role", "in", "the", "development", "of", "virus-induced", "airway", "obstruction"], "h": {"id": "C0014457", "name": "C0014457#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006271", "name": "C0006271#ent", "pos": [12, 13]}}
{"token": ["One", "of", "the", "2", "patients", "with", "preoperative", "unilateral", "C0042928#ent", "<e1>", "return", "of", "function", "after", "removal", "of", "a", "C0018024#ent", "<e2>"], "h": {"id": "C0042928", "name": "C0042928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018024", "name": "C0018024#ent", "pos": [17, 18]}}
{"token": ["Surveys", "indicate", "that", "persons", "with", "C0524910#ent", "<e1>", "CHC", ")", "often", "use", "herbals", ",", "especially", "C0037135#ent", "<e2>", "(", "milk", "thistle", "extract", ",", "hoping", "to", "improve", "the", "modest", "response", "to", "antiviral", "therapy", "reduce", "side", "effects"], "h": {"id": "C0524910", "name": "C0524910#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037135", "name": "C0037135#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "with", "C0077316#ent", "<e1>", "apparently", "protected", "the", "C0172956#ent", "<e2>", "ethanol", "activation", "."], "h": {"id": "C0077316", "name": "C0077316#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0172956", "name": "C0172956#ent", "pos": [7, 8]}}
{"token": ["He", "had", "a", "background", "history", "of", "sero-positive", "rheumatoid", "arthritis", "was", "well", "controlled", "on", "immunomodulatory", "disease", "C0003191#ent", "<e1>", "DMARDS", ")", "including", "methotrexate", "and", "C0063041#ent", "<e2>"], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [15, 16]}, "relation": "therapeutic_class_of", "t": {"id": "C0063041", "name": "C0063041#ent", "pos": [22, 23]}}
{"token": ["All", "C3541394#ent", "<e1>", "were", "separated", "on", "cellulose", "acetate", "foil", ",", "C1418664#ent", "<e2>", "in", "starch", "gel"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418664", "name": "C1418664#ent", "pos": [10, 11]}}
{"token": ["The", "influence", "of", "vaccination", "with", "an", "immunogenic", "C3272787#ent", "<e1>", "Escherichia", "coli", "the", "course", "of", "C0520575#ent", "<e2>", "induced", "experimentally", "in", "rats", "by", "infection", "with", "Escherichia", "coli", "was", "investigated", "."], "h": {"id": "C3272787", "name": "C3272787#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0520575", "name": "C0520575#ent", "pos": [14, 15]}}
{"token": ["It", "was", "concluded", "that", "Fru-2,6-P2", "strongly", "affects", "the", "interaction", "of", "AMP", "with", "C0016755#ent", "<e1>", "and", "that", "the", "C0242209#ent", "<e2>", "most", "likely", "acts", "at", "the", "active", "site", "the", "enzyme", "."], "h": {"id": "C0016755", "name": "C0016755#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242209", "name": "C0242209#ent", "pos": [17, 18]}}
{"token": ["At", "maximally", "effective", "concentrations", ",", "C0040373#ent", "<e1>", "did", "not", "affect", "C1706373#ent", "<e2>", "or", "cyclic", "AMP", "phosphodiesterase", "activities", "associated", "with", "cyclase", "preparations", "."], "h": {"id": "C0040373", "name": "C0040373#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [10, 11]}}
{"token": ["Short-chain", "acyl-CoA", "dehydrogenase", "C2826550#ent", "<e1>", ")", "deficiency", "is", "an", "inherited", "C0025517#ent", "<e2>", "biochemically", "characterized", "by", "tissue", "accumulation", "of", "predominantly", "ethylmalonic", "acid", "EMA", ")", "and", "clinically", "by", "neurological", "dysfunction"], "h": {"id": "C2826550", "name": "C2826550#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [10, 11]}}
{"token": ["In", "this", "paper", ",", "the", "clinical", "differences", "fourth", "ventricle", "cysts", "C1455718#ent", "<e1>", "are", "presented", "in", "16", "patients", "with", "C0010678#ent", "<e2>", "who", "were", "subjected", "to", "surgical", "exploration", "the", "posterior", "fossa"], "h": {"id": "C1455718", "name": "C1455718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010678", "name": "C0010678#ent", "pos": [18, 19]}}
{"token": ["C0009325#ent", "<e1>", "was", "extracted", "from", "C0520575#ent", "<e2>", "and", "normal", "kidney", "tissue", "with", "dilute", "acetic", "acid", "limited", "proteolysis", "with", "pepsin", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0520575", "name": "C0520575#ent", "pos": [5, 6]}}
{"token": ["As", "in", "the", "rat", "pituitary", "and", "brain", ",", "CRF", "receptors", "monkey", "cerebral", "cortex", "C0002707#ent", "<e1>", "were", "coupled", "to", "C1382029#ent", "<e2>"], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [18, 19]}}
{"token": ["In", "the", "medial", "hypothalamus", "not", "in", "the", "anterior", "hypothalamus", "C0002707#ent", "<e1>", ",", "stimulation", "of", "C1382029#ent", "<e2>", "dopamine", "was", "enhanced", "during", "proestrus", "and", "following", "castration", "."], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [14, 15]}}
{"token": ["C0024137#ent", "<e1>", "CLE", ")", "is", "a", "C0004364#ent", "<e2>", "welldefined", "skin", "lesions", ",", "including", "acute", "CLE", ",", "subacute", "CLE", ",", "chronic", "CLE", "and", "intermittent", "CLE", "."], "h": {"id": "C0024137", "name": "C0024137#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [6, 7]}}
{"token": ["The", "decreased", "response", "to", "beta-adrenoceptor", "stimulation", "in", "C0018802#ent", "<e1>", "be", "related", "to", "a", "defect", "in", "cyclic", "C4285220#ent", "<e2>", "production", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4285220", "name": "C4285220#ent", "pos": [16, 17]}}
{"token": ["Apart", "from", "C0042291#ent", "<e1>", "barbiturates", ",", "chlorprotixene", ",", "tricyclic", "antidepressants", "C0039663#ent", "<e2>", "and", "alcohol", "were", "detected", "and", "measured", "."], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039663", "name": "C0039663#ent", "pos": [10, 11]}}
{"token": ["C3273406#ent", "<e1>", "induced", "vasoconstriction", ",", "stimulation", "of", "C0752224#ent", "<e2>", "release", ",", "and", "inhibition", "of", "renin", "secretion"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752224", "name": "C0752224#ent", "pos": [7, 8]}}
{"token": ["It", "was", "found", "that", "the", "oxidative", "enzymatic", "activity", "(", "succinic", "dehydrogenase", "DPN-diaphorase", ",", "and", "several", "other", "C3541394#ent", "<e1>", ")", "of", "astrocytes", "depended", "on", "the", "concentration", "of", "C1412125#ent", "<e2>", "in", "the", "environment", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [26, 27]}}
{"token": ["In", "these", "isolates", ",", "inhibition", "of", "OXA", "C3541394#ent", "<e1>", "by", "200", "mM", "C1412125#ent", "<e2>", "reduced", "the", "imipenem", "MIC", "by", "up", "to", "four-fold", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [12, 13]}}
{"token": ["Amiodarone", "(", "C0340293#ent", "<e1>", ")", "is", "a", "potent", "C0003195#ent", "<e2>", "but", "its", "metabolism", "has", "not", "yet", "been", "fully", "documented", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["Amiodarone", "(", "C0340293#ent", "<e1>", ")", "is", "a", "potent", "C0003195#ent", "<e2>", "mono-N-desethylamiodarone", "(", "MDEA", ")", "is", "its", "only", "known", "metabolite", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["Amiodarone", "(", "C0340293#ent", "<e1>", ")", "is", "a", "potent", "C0003195#ent", "<e2>", "however", ",", "its", "clinical", "use", "limited", "due", "to", "numerous", "side", "effects"], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["Global", "biosecurity", "threats", "such", "as", "the", "spread", "of", "emerging", "infectious", "diseases", "i.e.", ",", "C0016627#ent", "<e1>", "SARS", ",", "Hendra", ",", "C0152171#ent", "<e2>", ",", "etc", ".", ")"], "h": {"id": "C0016627", "name": "C0016627#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0152171", "name": "C0152171#ent", "pos": [19, 20]}}
{"token": ["C0151436#ent", "<e1>", "CLV", ")", "is", "a", "C1290884#ent", "<e2>", "the", "small", "vessels", "the", "dermis", "."], "h": {"id": "C0151436", "name": "C0151436#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [6, 7]}}
{"token": ["The", "most", "common", "causes", "of", "C0151436#ent", "<e1>", "drug", "reactions", "infectious", "diseases", "reactions", "to", "C1290884#ent", "<e2>", "as", "rheumatoid", "arthritis", "inflammatory", "bowel", "disease", "or", "association", "with", "malignant", "disease", "especially", "lymphoproliferative", "disorders"], "h": {"id": "C0151436", "name": "C0151436#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [13, 14]}}
{"token": ["In", "this", "manuscript", ",", "we", "established", "through", "spectral", "analysis", "several", "C0360363#ent", "<e1>", "bind", "MT", "C4277553#ent", "<e2>", "with", "high", "affinity", "."], "h": {"id": "C0360363", "name": "C0360363#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4277553", "name": "C4277553#ent", "pos": [14, 15]}}
{"token": ["Immunoblotting", "studies", "with", "extracts", "from", "mouse", "hematopoietic", "cells", "that", "Jak2", ",", "but", "not", "C1451575#ent", "<e1>", ",", "was", "present", "in", "C1705637#ent", "<e2>", "immunoprecipitates", ",", "suggesting", "that", "SHP-1", "selectively", "associates", "with", "Jak2", "in", "vivo"], "h": {"id": "C1451575", "name": "C1451575#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705637", "name": "C1705637#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "suggest", "that", "one", "function", "of", "hSPRY2", "in", "signaling", "processes", "downstream", "of", "C1538314#ent", "<e1>", "may", "be", "to", "modulate", "C1707078#ent", "<e2>", "physiological", "function", "as", "that", "seen", "with", "receptor-mediated", "endocytosis"], "h": {"id": "C1538314", "name": "C1538314#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1707078", "name": "C1707078#ent", "pos": [19, 20]}}
{"token": ["The", "role", "of", "individual", "PKC", "C0026794#ent", "<e1>", "in", "the", "regulation", "of", "C3889284#ent", "<e2>", "and", "Nav1.8", "was", "determined", "using", "PKC-isozyme-specific", "peptide", "activators", "and", "inhibitors", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889284", "name": "C3889284#ent", "pos": [11, 12]}}
{"token": ["In", "the", "present", "study", ",", "C0700538#ent", "<e1>", "GS", ")", "and", "6-hydroxydopamine", "(", "C1422386#ent", "<e2>", ")", "were", "administered", "to", "gerbils", "to", "induce", "sympathectomy", "."], "h": {"id": "C0700538", "name": "C0700538#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422386", "name": "C1422386#ent", "pos": [12, 13]}}
{"token": ["Pulsed", "field", "gel", "electrophoresis", "Southern", "blot", "analysis", "that", "the", "human", "oncogenes", ",", "HST1", "and", "C0812290#ent", "<e1>", ",", "which", "code", "for", "proteins", "C1512488#ent", "<e2>", "to", "fibroblast", "growth", "factors", "are", "less", "than", "45", "kb", "apart", "on", "the", "long", "arm", "of", "chromosome", "11"], "h": {"id": "C0812290", "name": "C0812290#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [21, 22]}}
{"token": ["Patients", "with", "C0005283#ent", "<e1>", "who", "receive", "multiple", "blood", "transfusions", "at", "risk", "for", "the", "C0001175#ent", "<e2>"], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [13, 14]}}
{"token": ["Despite", "C1136254#ent", "<e1>", "the", "patient", "had", "an", "episode", "of", "C0019079#ent", "<e2>", "died", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019079", "name": "C0019079#ent", "pos": [9, 10]}}
{"token": ["Thus", "C1833296#ent", "<e1>", "contracted", "more", "potently", "the", "venous", "strips", "the", "C0030196#ent", "<e2>"], "h": {"id": "C1833296", "name": "C1833296#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [10, 11]}}
{"token": ["We", "tested", "the", "safety", "and", "antiviral", "efficacy", "a", "novel", "combination", "consisting", "of", "efavirenz", ",", "C0886530#ent", "<e1>", ",", "and", "one", "or", "more", "C3537104#ent", "<e2>", "57", "children", "previously", "treated", "with", "C3537104#ent", "<e2>"], "h": {"id": "C0886530", "name": "C0886530#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3537104", "name": "C3537104#ent", "pos": [21, 22]}}
{"token": ["C0020625#ent", "<e1>", "has", "been", "reported", "as", "a", "rare", "adverse", "effect", "selective", "C0162758#ent", "<e2>"], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [11, 12]}}
{"token": ["C0020625#ent", "<e1>", "has", "been", "observed", "in", "elderly", "patients", "treated", "with", "selective", "C0162758#ent", "<e2>", "SSRI", ")", "fluoxetine", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [11, 12]}}
{"token": ["Thus", "C1413917#ent", "<e1>", ",", "a", "ligand", "of", "the", "C1823521#ent", "<e2>", "whose", "occupation", "may", "facilitate", "mitochondrial", "membrane", "permeabilization", ",", "was", "found", "among", "the", "released", "proteins", "."], "h": {"id": "C1413917", "name": "C1413917#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [8, 9]}}
{"token": ["We", "also", "showed", "that", "C1413917#ent", "<e1>", ",", "as", "the", "endogenous", "C1823521#ent", "<e2>", "ligand", ",", "stimulates", "cholesterol", "transport"], "h": {"id": "C1413917", "name": "C1413917#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [10, 11]}}
{"token": ["Both", "3-O-Me-SM", "and", "C0001047#ent", "<e1>", ",", "the", "selective", "and", "nonselective", "pharmacological", "inhibitors", "C3539580#ent", "<e2>", ",", "respectively", ",", "suppressed", "nSMase", "activation", ",", "ceramide", "production", "and", "cytotoxic", "action", "induced", "by", "Abeta25-35", "CECs", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539580", "name": "C3539580#ent", "pos": [12, 13]}}
{"token": ["These", "cells", "produce", ":", "interleukin", "(IL)-5", "IL-3", "and", "granulocyte", "macrophage", "colony-stimulating", "factor", "which", "recruit", ",", "mobilize", "and", "activate", "eosinophils", "for", "subsequent", "mucosal", "tissue", "damage", "and", "C1334119#ent", "<e1>", ",", "an", "essential", "C0003438#ent", "<e2>", "for", "local", "or", "generalized", "IgE", "production", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [30, 31]}}
{"token": ["The", "tumors", "did", "not", "respond", "to", "combination", "chemotherapy", "dacarbazine", ",", "C0243666#ent", "<e1>", ",", "vincristine", ",", "and", "C0751599#ent", "<e2>", "."], "h": {"id": "C0243666", "name": "C0243666#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751599", "name": "C0751599#ent", "pos": [16, 17]}}
{"token": ["The", "blocking", "action", "of", "both", "bupivacaine", "and", "C0055443#ent", "<e1>", "caused", "a", "decrease", "in", "amplitude", "in", "the", "C0225326#ent", "<e2>", "twice", "as", "great", "as", "that", "produced", "in", "the", "C", "fibres"], "h": {"id": "C0055443", "name": "C0055443#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [16, 17]}}
{"token": ["These", "studies", "implicate", "the", "NO", "pathway", "the", "pathogenesis", "of", "an", "C3899281#ent", "<e1>", "demonstrate", "the", "ability", "of", "a", "C1705516#ent", "<e2>", "inhibitor", "to", "modulate", "the", "disease", "."], "h": {"id": "C3899281", "name": "C3899281#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705516", "name": "C1705516#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", "the", "cost", "effectiveness", "of", "the", "b-blocker", "C0054836#ent", "<e1>", "when", "added", "to", "standard", "therapy", "patients", "with", "severe", "C0018801#ent", "<e2>", "determined", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["Recent", "clinical", "studies", "suggested", "that", "C0054836#ent", "<e1>", "may", "improve", "left", "ventricular", "function", "symptoms", "in", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [16, 17]}}
{"token": ["Gene", "transfer", "the", "C2732002#ent", "<e1>", "cDNA", "to", "C0669372#ent", "<e2>", "using", "lentiviral", "vectors", "a", "potential", "therapeutic", "approach"], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [7, 8]}}
{"token": ["Low", "but", "significant", "levels", "of", "C2732002#ent", "<e1>", "mRNA", "were", "also", "detected", "in", "the", "C0669372#ent", "<e2>", "."], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "the", "CAPS", "marker", "will", "be", "useful", "for", "marker-assisted", "selection", "(", "C0025048#ent", "<e1>", ")", "of", "pepper", "breeding", "lines", "with", "the", "up", "C1706112#ent", "<e2>", "at", "the", "early", "seedling", "stage", "."], "h": {"id": "C0025048", "name": "C0025048#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [22, 23]}}
{"token": ["The", "induction", "factors", "of", "the", "SOS", "chromotest", "in", "Escherichia", "coli", "PQ", "37", "were", "dependent", "on", "the", "concentrations", "of", "C1420806#ent", "<e1>", "and", "soybean", "cooking", "oil", "extracts", "without", "C4085198#ent", "<e2>"], "h": {"id": "C1420806", "name": "C1420806#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4085198", "name": "C4085198#ent", "pos": [26, 27]}}
{"token": ["The", "specific", "PKC", "inhibitor", "C0054537#ent", "<e1>", "suppressed", "activation", "of", "MAP", "kinase", "by", "C1705725#ent", "<e2>", "and", "PMA", ",", "but", "had", "no", "effect", "that", "produced", "by", "Tg", "and", "CPA", "."], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [12, 13]}}
{"token": ["C0054537#ent", "<e1>", "inhibited", "the", "C1705725#ent", "<e2>", "and", "PMA-induced", "cPLA", "2", "activation", ",", "but", "had", "no", "influence", "on", "thapsigargin-", "and", "cyclopiazonic", "acid-treated", "cells", "."], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [4, 5]}}
{"token": ["In", "ReA", "C1366480#ent", "<e1>", ",", "in", "contrast", "to", "monocytes", ",", "all", "C0064833#ent", "<e2>", "(", "PMN", ")", "cells", "contained", "cathepsin", "G", "elastase", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [11, 12]}}
{"token": ["In", "chronic", "cases", "focal", "complications", "eg", ",", "C0038012#ent", "<e1>", ",", "neurobrucellosis", "and", "C0014118#ent", "<e2>", ")", "are", "frequently", "seen", "."], "h": {"id": "C0038012", "name": "C0038012#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [12, 13]}}
{"token": ["Contrast", "to", "endothelial", "cells", "in", "pericytes", ",", "subsequent", "mitogenic", "process", "be", "negatively", "regulated", "by", "the", "inhibitory", "effects", "of", "high", "glucose", "PI", "and", "C3811118#ent", "<e1>", "hydrolysis", ",", "resulting", "in", "reduced", "levels", "of", "PC-derived", "C1413902#ent", "<e2>", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1413902", "name": "C1413902#ent", "pos": [32, 33]}}
{"token": ["In", "summary", ",", "IL-4R", "signaling", "in", "monocytes", "and", "U937", "cells", "PLC", "and", "not", "PLD", ",", "PLA2", ",", "or", "SMase", ",", "and", "it", "uses", "C3811118#ent", "<e1>", "and", "not", "PIP2", "to", "form", "C1413902#ent", "<e2>", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1413902", "name": "C1413902#ent", "pos": [30, 31]}}
{"token": ["Type", "I", "II", "diabetes", "to", "contribute", "importantly", "to", "C0022661#ent", "<e1>", "although", ",", "obviously", ",", "the", "prevalence", "of", "C0022661#ent", "<e1>", "is", "higher", "in", "Type", "I.", "Microalbuminuria", "predict", "later", "development", "of", "overt", "C0022658#ent", "<e1>", "both", "Type", "I", "Type", "II", "patients", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [30, 31]}}
{"token": ["In", "addition", ",", "according", "to", "phase", "II", "randomized", "trials", "promising", "new", "treatments", "for", "vasospasm", "or", "its", "ischaemic", "complications", "include", "magnesium", "sulfate", "the", "selective", "C1516869#ent", "<e1>", "clazosentan", ",", "and", "C0360714#ent", "<e2>", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0360714", "name": "C0360714#ent", "pos": [28, 29]}}
{"token": ["Only", "one", "of", "several", "available", "ophthalmic", "nonsteroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", "is", "currently", "FDA", "approved", "for", "use", "in", "acute", "seasonal", "allergic", "conjunctivitis", "C1854580#ent", "<e2>", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1854580", "name": "C1854580#ent", "pos": [23, 24]}}
{"token": ["C0014310#ent", "<e1>", "was", "as", "effective", "as", "tobramycin", "against", "P.", "cepacia", "and", "C0014836#ent", "<e2>"], "h": {"id": "C0014310", "name": "C0014310#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014836", "name": "C0014836#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "reported", "the", "isolation", "of", "the", "ribonucleoprotein", "SYT-interacting", "protein/co-activator", "activator", "(", "SIP/CoAA", ")", ",", "which", "specifically", "binds", "the", "QPGY", "domain", "of", "C1420439#ent", "<e1>", "and", "also", "the", "C1846243#ent", "<e2>", "translocation", "fusion", "."], "h": {"id": "C1420439", "name": "C1420439#ent", "pos": [22, 23]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1846243", "name": "C1846243#ent", "pos": [27, 28]}}
{"token": ["In", "no", "case", "was", "there", "an", "appreciable", "alteration", "in", "C1260386#ent", "<e1>", "concentration", "during", "C2917660#ent", "<e2>", "uptake", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [13, 14]}}
{"token": ["C0812382#ent", "<e1>", "is", "identical", "to", "the", "differentiation-related", "antigen", "murine", "C2984182#ent", "<e2>", "or", "human", "kidney", "gp160", "and", "is", "involved", "in", "regulating", "cell", "differentiation", "neoplastic", "transformation", "certain", "normal", "and", "transformed", "cells"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2984182", "name": "C2984182#ent", "pos": [9, 10]}}
{"token": ["C0035579#ent", "<e1>", "was", "found", "in", "some", "patients", "but", "seemed", "related", "to", "C0042870#ent", "<e2>"], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0042870", "name": "C0042870#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "mothers", "of", "C0035579#ent", "<e1>", "children", "should", "be", "investigated", "and", "treated", "for", "C0042870#ent", "<e2>"], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0042870", "name": "C0042870#ent", "pos": [14, 15]}}
{"token": ["The", "mouse", "C1413269#ent", "<e1>", "its", "human", "C1334043#ent", "<e2>", "OB", "have", "recently", "been", "cloned", "."], "h": {"id": "C1413269", "name": "C1413269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}}
{"token": ["The", "mouse", "C1413269#ent", "<e1>", "its", "human", "C1334043#ent", "<e2>", "have", "been", "cloned", "and", "sequenced", "."], "h": {"id": "C1413269", "name": "C1413269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}}
{"token": ["The", "liver", "X", "receptor", "LXR", ")", ",", "a", "transcription", "factor", "forms", "a", "heterodimer", "with", "the", "retinoid", "X", "receptor", "plays", "a", "key", "role", "in", "the", "C1710463#ent", "<e1>", "many", "important", "genes", "implicated", "in", "prevalent", "C0025517#ent", "<e2>"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [32, 33]}}
{"token": ["Thermospray", "liquid", "chromatography-mass", "spectrometry", "C1336626#ent", "<e1>", "LC-MS", ")", "was", "used", "to", "determine", "human", "urinary", "metabolites", "C0085173#ent", "<e2>", "after", "oral", "administration", "C0085173#ent", "<e2>", "tablets", "."], "h": {"id": "C1336626", "name": "C1336626#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [15, 16]}}
{"token": ["In", "addition", "to", "naturally", "occurring", "mutations", ",", "several", "C0031727#ent", "<e1>", "including", "Akt", ",", "RSK1", ",", "and", "C3849574#ent", "<e2>", "are", "known", "to", "phosphorylate", "and", "inactivate", "tuberin", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [16, 17]}}
{"token": ["The", "nonspecific", "phospholipase", "C", "Bacillus", "cereus", "a", "C0596918#ent", "<e1>", "catalyzes", "the", "hydrolysis", "of", "phospholipids", "to", "yield", "diacylglycerol", "a", "C0002059#ent", "<e2>"], "h": {"id": "C0596918", "name": "C0596918#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002059", "name": "C0002059#ent", "pos": [18, 19]}}
{"token": ["There", "are", "now", "five", "nucleoside/nucleotide", "analogs", "for", "the", "treatment", "of", "chronic", "hepatitis", "B", "C0151517#ent", "<e1>", ")", "including", "three", "C0991617#ent", "<e2>", "approved", "in", "the", "United", "States", "European", "Union", "the", "past", "three", "years", "."], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [18, 19]}}
{"token": ["Gradients", "of", "neurogenesis", "were", "detected", "along", "ventral-dorsal", "and", "lateral-medial", "axes", "in", "the", "Rot", ",", "but", "only", "the", "latter", "C1997362#ent", "<e1>", "gradient", "occurred", "in", "the", "C0023521#ent", "<e2>", "."], "h": {"id": "C1997362", "name": "C1997362#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0023521", "name": "C0023521#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "like", "phenobarbital", ",", "C0013092#ent", "<e1>", "treatment", "resulted", "in", "a", "modest", "induction", "of", "CYP3A", "and", "C0599930#ent", "<e2>", "enzymes", "and", "approximately", "a", "50", "%", "increase", "in", "thyroxine-glucuronosyltransferase", "activity"], "h": {"id": "C0013092", "name": "C0013092#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0599930", "name": "C0599930#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "BAL", "patients", "need", "a", "more", "aggressive", "treatment", "procedure", "including", "high-dose", "C0017338#ent", "<e1>", "or", "the", "use", "of", "C1422070#ent", "<e2>", "modulators", "for", "first-line", "therapy"], "h": {"id": "C0017338", "name": "C0017338#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [19, 20]}}
{"token": ["Exposure", "of", "T98", "G", "and", "A172", "cells", "to", "C0771987#ent", "<e1>", "did", "not", "affect", "their", "C4042483#ent", "<e2>", "."], "h": {"id": "C0771987", "name": "C0771987#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4042483", "name": "C4042483#ent", "pos": [14, 15]}}
{"token": ["This", "study", "compares", "the", "prevalence", "and", "severity", "of", "C0011168#ent", "<e1>", "symptoms", "in", "subjects", "with", "or", "without", "gastroesophageal", "reflux", "C0017168#ent", "<e2>", ")", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [18, 19]}}
{"token": ["At", "5", "days", "of", "age", ",", "both", "twins", "experienced", "poor", "feeding", "C0023380#ent", "<e1>", "and", "hypothermia", ",", "and", "evidence", "of", "C0005779#ent", "<e2>", "and", "hepatitis", "."], "h": {"id": "C0023380", "name": "C0023380#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", "to", "the", "acquired", "C1414137#ent", "<e1>", ",", "mutations", "of", "the", "C1333342#ent", "<e2>", "thrombopoietin", "receptor", "been", "identified", "in", "familial", "forms", "nonclonal", "erythrocytosis", "thrombocytosis", ",", "respectively", "."], "h": {"id": "C1414137", "name": "C1414137#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333342", "name": "C1333342#ent", "pos": [11, 12]}}
{"token": ["Angiotensin", "II", "C1424250#ent", "<e1>", ")", "acts", "as", "a", "C0812325#ent", "<e2>", "local", "systems", "mediating", "diverse", "effects", "such", "as", "cellular", "proliferation", "apoptosis", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [8, 9]}}
{"token": ["Angiotensin", "II", "C1424250#ent", "<e1>", ")", "is", "a", "C0812325#ent", "<e2>", "stimulates", "protein", "synthesis", "induces", "cellular", "hypertrophy", "aortic", "smooth", "muscle", "cells", "SMC", ")", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [7, 8]}}
{"token": ["We", "determined", "whether", "angiotensin", "II", "C1424250#ent", "<e1>", ")", ",", "which", "acts", "as", "a", "C0812325#ent", "<e2>", "many", "cell", "types", "could", "activate", "the", "Stat91", "pathway", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [13, 14]}}
{"token": ["The", "same", "percentages", "of", "cells", "demonstrated", "C1412133#ent", "<e1>", "activities", "but", "were", "devoid", "of", "C1257646#ent", "<e2>", "."], "h": {"id": "C1412133", "name": "C1412133#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "it", "appears", "that", "amdinocillin", "may", "potentiate", "the", "activity", "of", "other", "beta-lactam", "drugs", "only", "by", "binding", "to", "a", "complementary", "C0070235#ent", "<e1>", "also", "by", "causing", "leakage", "of", "C0005244#ent", "<e2>", "from", "the", "cell", "."], "h": {"id": "C0070235", "name": "C0070235#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0005244", "name": "C0005244#ent", "pos": [27, 28]}}
{"token": ["C0070235#ent", "<e1>", "PBPs", ")", "are", "involved", "in", "the", "regulation", "of", "C0005244#ent", "<e2>", "expression", "by", "determining", "the", "level", "of", "anhydromuramylpeptides", "in", "the", "periplasmatic", "space"], "h": {"id": "C0070235", "name": "C0070235#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005244", "name": "C0005244#ent", "pos": [10, 11]}}
{"token": ["Using", "rolling", "circle", "DNA", "substrates", "model", "replication", "forks", "we", "examine", "the", "fate", "of", "the", "helicase", "and", "both", "C0012892#ent", "<e1>", "the", "leading", "C1335440#ent", "<e2>", "blocked", "."], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [21, 22]}}
{"token": ["African", "swine", "fever", "virus", "ASFV", ")", "encodes", "a", "novel", "C0012892#ent", "<e1>", "constituted", "of", "only", "174", "amino", "acids", "belonging", "to", "the", "C1335440#ent", "<e2>", "(", "pol", ")", "X", "family", "of", "DNA", "polymerases"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [20, 21]}}
{"token": ["Daily", "intraperitoneal", "injection", "of", "3", "mg/kg", "C0065374#ent", "<e1>", "was", "instituted", "starting", "four", "weeks", "after", "injury", "for", "a", "C0720099#ent", "<e2>", "of", "six", "weeks", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [17, 18]}}
{"token": ["C0037862#ent", "<e1>", "are", "known", "to", "have", "antimicrobial", "activity", "other", "sexually", "transmitted", "C0012634#ent", "<e2>", "and", "the", "aim", "of", "this", "study", "was", "to", "test", "whether", "the", "causative", "organisms", "BV", "were", "also", "susceptible", "to", "spermicides", ",", "in", "vitro"], "h": {"id": "C0037862", "name": "C0037862#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["A", "few", "weakly", "expressed", "C1332710#ent", "<e1>", "seen", "in", "normal", "limbal", "cornea", "no", "immunoreactivity", "for", "C1416655#ent", "<e2>", "and", "STRO-1", "could", "be", "found", "."], "h": {"id": "C1332710", "name": "C1332710#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [14, 15]}}
{"token": ["This", "assay", "quantitates", "and", "differentiates", "C1420369#ent", "<e1>", "and", "beta-2", "adrenergic", "binding", "of", "synthetic", "C0001637#ent", "<e2>"], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001637", "name": "C0001637#ent", "pos": [13, 14]}}
{"token": ["Knockdown", "of", "C1421941#ent", "<e1>", "also", "led", "to", "increased", "C0017346#ent", "<e2>", "degradation", ",", "resulting", "in", "reduced", "intracellular", "Gag", "protein", ";", "this", "phenotype", "was", "rescued", "by", "reintroduction", "of", "C1421941#ent", "<e1>", "."], "h": {"id": "C1421941", "name": "C1421941#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [8, 9]}}
{"token": ["In", "vitro", "C1312419#ent", "<e1>", "91", "ovarian", "cancer", "specimens", "revealed", "elevated", "levels", "of", "C0812230#ent", "<e2>", "activity", "(", ">", "3-fold", ")", "in", "33", "cases", "(", "36.3", "%", ")", "."], "h": {"id": "C1312419", "name": "C1312419#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812230", "name": "C0812230#ent", "pos": [12, 13]}}
{"token": ["No", "significant", "in", "BALP", ",", "ALP", ",", "OC", ",", "NTx", ",", "C1705340#ent", "<e1>", ",", "calcium", "or", "phosphorus", "levels", "were", "observed", "between", "the", "C0162311#ent", "<e2>", "and", "the", "IUGR", "groups", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162311", "name": "C0162311#ent", "pos": [22, 23]}}
{"token": ["We", "recommend", "that", "C3273279#ent", "<e1>", "must", "be", "considered", "in", "cases", "of", "renal", "failure", "anaemia", "associated", "with", "pneumococcal", "meningitis", "and", "that", "C0025297#ent", "<e2>", "considered", "in", "all", "patients", "with", "C3273279#ent", "<e1>", "and", "central", "nervous", "system", "involvement", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3273279", "name": "C3273279#ent", "pos": [3, 4]}}
{"token": ["The", "limits", "of", "detection", "LOD", ")", "were", "0.9", "ng", "g(-1", ")", "for", "C1704868#ent", "<e1>", ",", "2", "ng", "g(-1", ")", "for", "C0041044#ent", "<e2>", "and", "3.1", "ng", "g(-1", ")", "for", "SDZ", "."], "h": {"id": "C1704868", "name": "C1704868#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [20, 21]}}
{"token": ["Eukaryotic", "elongation", "factor", "1A", "C1414270#ent", "<e1>", ")", "appears", "to", "be", "a", "C1415740#ent", "<e2>", "several", "biochemical", "activities", "been", "described", "for", "this", "protein", ",", "in", "addition", "to", "its", "role", "in", "protein", "synthesis"], "h": {"id": "C1414270", "name": "C1414270#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [11, 12]}}
{"token": ["Further", ",", "short-term", "C0171023#ent", "<e1>", "treatment", "attenuated", "the", "suppression", "of", "firing", "and", "excitability", "of", "C3889643#ent", "<e2>", "neurons", "induced", "by", "chronic", "fluoxetine", "treatment", "."], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889643", "name": "C3889643#ent", "pos": [14, 15]}}
{"token": ["C0171023#ent", "<e1>", "but", "not", "haloperidol", "reversed", "lesion-induced", "changes", "in", "C3889643#ent", "<e2>", "pyramidal", "cell", "dendrites", "."], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889643", "name": "C3889643#ent", "pos": [9, 10]}}
{"token": ["The", "molecular", "lesions", "underlie", "the", "resistance", "of", "the", "C0024530#ent", "<e1>", "parasites", "to", "C0165603#ent", "<e2>", ",", "a", "coenzyme", "Q", "analogue", "were", "investigated", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0165603", "name": "C0165603#ent", "pos": [12, 13]}}
{"token": ["A", "mutation", "within", "the", "ef", "loop", "that", "is", "associated", "with", "resistant", "C0024530#ent", "<e1>", "parasites", "rendered", "the", "complex", "resistant", "to", "C0165603#ent", "<e2>", ",", "thereby", "providing", "direct", "proof", "that", "the", "mutation", "causes", "C0165603#ent", "<e2>", "resistance", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}, "relation": "may_be_prevented_by", "t": {"id": "C0165603", "name": "C0165603#ent", "pos": [19, 20]}}
{"token": ["This", "region", "comprises", "the", "entire", "E1", "transcription", "unit", "the", "C1412821#ent", "<e1>", "ORF", ")", "for", "proteins", "homologous", "to", "the", "C1709313#ent", "<e2>", ",", "E1B", "proteins", "and", "protein", "IX", "human", "adenovirus", "type", "5", "Ad5", ")", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [18, 19]}}
{"token": ["Homology", "studies", "using", "the", "deduced", "amino", "acid", "of", "the", "C1412821#ent", "<e1>", "revealed", "genes", "coding", "for", "the", "C1709313#ent", "<e2>", ",", "E1B", "202R", ",", "E1B", "474R", "and", "pIX", "proteins"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [16, 17]}}
{"token": ["C0010200#ent", "<e1>", "was", "the", "most", "sensitive", "clinical", "indicator", "C0024115#ent", "<e2>", "being", "present", "in", "71.1", "%", "of", "horses", "with", "pulmonary", "disorders"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [8, 9]}}
{"token": ["Fourteen", "tumors", "with", "detectable", "NR4A3", "fusion", "genes", "C2675456#ent", "<e1>", ";", "TAF15-NR4A3", ")", "expressed", "neither", "native", "C1417837#ent", "<e2>", "nor", "SIX3", "."], "h": {"id": "C2675456", "name": "C2675456#ent", "pos": [7, 8]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1417837", "name": "C1417837#ent", "pos": [15, 16]}}
{"token": ["In", "two", "autopsy-proven", "cases", "of", "C0023264#ent", "<e1>", "SNE", ",", "Leigh's", "Disease", "the", "activities", "of", "pyruvate", "carboxylase", "C0034342#ent", "<e2>", "lipoamide", "dehydrogenase", "investigated", "in", "cultured", "fibroblasts", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [16, 17]}}
{"token": ["This", "patient", "with", "C0023264#ent", "<e1>", "an", "isolated", "deficiency", "of", "C0034342#ent", "<e2>", "various", "tissues", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [9, 10]}}
{"token": ["In", "two", "autopsy-proven", "cases", "of", "subacute", "necrotizing", "encephalomyelopathy", "SNE", ",", "C0023264#ent", "<e1>", "the", "activities", "of", "pyruvate", "carboxylase", "C0034342#ent", "<e2>", "lipoamide", "dehydrogenase", "investigated", "in", "cultured", "fibroblasts", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [17, 18]}}
{"token": ["The", "C1259236#ent", "<e1>", "genome", "integrity", "promoting", "cell", "cycle", "arrest", "apoptosis", "in", "response", "to", "DNA", "double-strand", "breaks", "and", "C1424448#ent", "<e2>", "mutations", "are", "found", "in", "both", "familial", "and", "sporadic", "cancers"], "h": {"id": "C1259236", "name": "C1259236#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1424448", "name": "C1424448#ent", "pos": [17, 18]}}
{"token": ["Akt/protein", "kinase", "B", "is", "a", "major", "cell", "survival", "pathway", "phosphorylation", "of", "proapoptotic", "proteins", "Bad", "and", "C0812198#ent", "<e1>", "and", "of", "additional", "apoptotic", "pathways", "to", "Forkhead", "proteins", "glycogen", "synthase", "kinase-3beta", "C3811165#ent", "<e2>", "."], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3811165", "name": "C3811165#ent", "pos": [28, 29]}}
{"token": ["The", "prevalence", "(", "%", ")", "of", "C0162667#ent", "<e1>", "parasites", "in", "327", "mainly", "adult", "C0615769#ent", "<e2>", "cats", "from", "3", "habitat", "groupings", "in", "Victoria", "and", "New", "South", "Wales", "determined", "."], "h": {"id": "C0162667", "name": "C0162667#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0615769", "name": "C0615769#ent", "pos": [13, 14]}}
{"token": ["The", "present", "study", "was", "performed", "to", "investigate", "the", "infection", "status", "with", "C0162667#ent", "<e1>", "in", "a", "group", "of", "C0615769#ent", "<e2>", "cats", "in", "Korea", "."], "h": {"id": "C0162667", "name": "C0162667#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0615769", "name": "C0615769#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "an", "effective", "C2741638#ent", "<e1>", "prophylaxis", "is", "absolutely", "indicated", "and", "H2-blocking", "agents", ",", "C3537307#ent", "<e2>", ",", "antacids", ",", "sucralfate", ",", "enteral", "nutrition", "prostaglandin", "E", "are", "recommended", "."], "h": {"id": "C2741638", "name": "C2741638#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537307", "name": "C3537307#ent", "pos": [14, 15]}}
{"token": ["In", "a", "patient", "affected", "by", "acute", "lymphoblastic", "leukemia", "C1704799#ent", "<e1>", ")", "and", "subjected", "to", "therapy", "with", "Erwinia", "L-asparaginase", "C0030583#ent", "<e2>", "observed", "."], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030583", "name": "C0030583#ent", "pos": [18, 19]}}
{"token": ["C0064698#ent", "<e1>", "has", "previously", "been", "shown", "to", "cause", "severe", "C1387532#ent", "<e2>", "renal", "tubular", "necrosis", "animals", "."], "h": {"id": "C0064698", "name": "C0064698#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1387532", "name": "C1387532#ent", "pos": [9, 10]}}
{"token": ["Experience", "of", "balloon", "dilation", "C0345030#ent", "<e1>", "PPS", ")", "in", "C0175702#ent", "<e2>", "WS", ")", "is", "limited", "."], "h": {"id": "C0345030", "name": "C0345030#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [9, 10]}}
{"token": ["The", "animals", "immunized", "with", "C1423896#ent", "<e1>", "showed", "decreased", "levels", "of", "C2936882#ent", "<e2>", "throughout", "their", "menstrual", "cycles", "and", "two", "of", "the", "animals", "ceased", "ovulation", "."], "h": {"id": "C1423896", "name": "C1423896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [10, 11]}}
{"token": ["For", "each", "CYP3A5", "high", "expresser", "(", "n=10", ")", ",", "the", "rate", "of", "M1", "formation", "C0042679#ent", "<e1>", "due", "to", "CYP3A5", "was", "quantified", "by", "subtracting", "the", "C1142644#ent", "<e2>", "contribution", "as", "determined", "by", "linear", "regression", "CYP3A5*3/*3", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [14, 15]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [24, 25]}}
{"token": ["Our", "findings", "demonstrate", "that", "in", "contrast", "to", "most", "CYP3A", "biotransformations", ",", "the", "oxidation", "of", "C0042679#ent", "<e1>", "is", "considerably", "more", "efficient", "with", "CYP3A5", "than", "with", "C1142644#ent", "<e2>", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [14, 15]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [24, 25]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "compare", "the", "effects", "of", "treatment", "with", "carvedilol", "versus", "C0025859#ent", "<e1>", "in", "patients", "with", "LV", "dysfunction", "C0027051#ent", "<e2>", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [22, 23]}}
{"token": ["The", "20,349-bp", "sequence", "of", "the", "human", "cytomegalovirus", "HCMV", ")", "HindIII", "F", "fragment", "has", "revealed", "eight", "C1412821#ent", "<e1>", "homology", "to", "herpes", "simplex", "virus", "HSV", ")", "and/or", "Epstein-Barr", "virus", "C0149678#ent", "<e2>", ")", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [27, 28]}}
{"token": ["Glycoprotein", "gp85", "the", "product", "of", "the", "BXLF2", "C1412821#ent", "<e1>", "ORF", ")", ",", "is", "the", "gH", "homolog", "of", "Epstein-Barr", "virus", "C0149678#ent", "<e2>", ")", "and", "has", "been", "implicated", "in", "penetration", "of", "virus", "into", "B", "cells"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [19, 20]}}
{"token": ["A", "sandwich", "enzyme-linked", "immunosorbent", "assay", "ELISA", ")", "for", "human", "C0536678#ent", "<e1>", "C0031667#ent", "<e2>", ")", "was", "developed", "using", "monoclonal", "antibodies", "against", "purified", "recombinant", "C0031667#ent", "<e2>", "."], "h": {"id": "C0536678", "name": "C0536678#ent", "pos": [9, 10]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [11, 12]}}
{"token": ["A", "C0536678#ent", "<e1>", "rabbit", "polymorphonuclear", "leukocytes", "a", "closely", "similar", "C0031667#ent", "<e2>", "rabbit", "serum", "have", "been", "purified", "to", "near", "homogeneity", "by", "ion-exchange", "and", "reverse-phase", "chromatography"], "h": {"id": "C0536678", "name": "C0536678#ent", "pos": [1, 2]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [9, 10]}}
{"token": ["This", "rapid", "and", "very", "sensitive", "method", "was", "successfully", "applied", "to", "the", "enzymes", "polygalacturonate", "lyase", "C0032491#ent", "<e1>", "endoglucanase", ",", "and", "C0043376#ent", "<e2>"], "h": {"id": "C0032491", "name": "C0032491#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0043376", "name": "C0043376#ent", "pos": [19, 20]}}
{"token": ["Since", "earlier", "studies", "showed", "a", "selective", "impairment", "in", "the", "high", "affinity", "uptake", "of", "serotonin", "by", "cerebellar", "synaptosomes", ",", "thiamine", "deficiency", "impair", "C0742034#ent", "<e1>", "inducing", "an", "imbalance", "in", "its", "C0243051#ent", "<e2>"], "h": {"id": "C0742034", "name": "C0742034#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [28, 29]}}
{"token": ["The", "antibodies", "were", "shown", "by", "immunoblotting", "to", "bind", "specifically", "to", "C3540507#ent", "<e1>", "but", "also", "to", "C1413309#ent", "<e2>", "with", "C8", "alpha", "the", "alpha", "subunit", "complement", "component", "C8"], "h": {"id": "C3540507", "name": "C3540507#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [15, 16]}}
{"token": ["Activation", "of", "C1332758#ent", "<e1>", "to", "several", "biochemical", "events", "an", "increased", "turnover", "of", "C4277588#ent", "<e2>", "."], "h": {"id": "C1332758", "name": "C1332758#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4277588", "name": "C4277588#ent", "pos": [12, 13]}}
{"token": ["Two", "iatrogenic", "effects", "of", "antipsychotic", "medications", "than", "C0686347#ent", "<e1>", "been", "recently", "described", "in", "schizophrenic", "populations", "C0085623#ent", "<e2>", "and", "tardive", "dysmentia", "."], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085623", "name": "C0085623#ent", "pos": [15, 16]}}
{"token": ["Subsequent", "characterization", "of", "the", "purified", "C1705072#ent", "<e1>", "mutant", "proteins", "demonstrated", "that", "pectinolytic", "function", "involves", "C3539946#ent", "<e2>", "near", "the", "calcium", "binding", "site", "than", "those", "surrounding", "an", "invariant", "vWiDH", "sequence", "."], "h": {"id": "C1705072", "name": "C1705072#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [14, 15]}}
{"token": ["Specific", "C2963170#ent", "<e1>", "Surinam", "include", "high", "prevalence", "of", "infections", ",", "mostly", "C4082764#ent", "<e2>", "young", "children", ",", "malaria", "and", "injuries", "due", "to", "violence", "."], "h": {"id": "C2963170", "name": "C2963170#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4082764", "name": "C4082764#ent", "pos": [11, 12]}}
{"token": ["Denatured", "II", "ant-collagen", "antibodies", "are", "common", "during", "ankylosing", "spondylarthritis", "35", "percent", ")", "and", "diffuse", "sclerodermia", "and", "are", "found", "in", "C0003873#ent", "<e1>", "23", "percent", ")", "and", "in", "C1527336#ent", "<e2>", "25", "percent", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}, "relation": "manifestation_of", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [26, 27]}}
{"token": ["These", "studies", "confirm", "peripheral", "airways", "dysfunction", "after", "uncomplicated", "C0021400#ent", "<e1>", "suggest", "that", "C0002403#ent", "<e2>", "is", "associated", "with", "accelerated", "resolution", "of", "this", "dysfunction", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0002403", "name": "C0002403#ent", "pos": [12, 13]}}
{"token": ["Antiviral", "chemotherapy", "C0021400#ent", "<e1>", "started", "with", "treatment", "with", "C0002403#ent", "<e2>", "and", "then", "progressed", "with", "finding", "the", "clinical", "efficacy", "neuraminidase", "(", "NA", ")", "inhibitors", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [2, 3]}, "relation": "may_be_prevented_by", "t": {"id": "C0002403", "name": "C0002403#ent", "pos": [8, 9]}}
{"token": ["This", "study", "reports", "the", "results", "that", "were", "obtained", "in", "56", "cases", "of", "C0020538#ent", "<e1>", "pregnancy", "solely", "by", "beta-blocking", "with", "C0004147#ent", "<e2>", "or", "Labetalol", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [19, 20]}}
{"token": ["In", "the", "Losartan", "Intervention", "for", "End", "Point", "in", "C0020538#ent", "<e1>", "LIFE", ")", ",", "losartan", "was", "compared", "to", "C0004147#ent", "<e2>", "in", "hypertensives", "with", "the", "additional", "risk", "factor", "left", "ventricular", "hypertrophy", "LVH", ")", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [17, 18]}}
{"token": ["C0020538#ent", "<e1>", "the", "described", "case", "was", "successfully", "treated", "with", "C0004147#ent", "<e2>", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [9, 10]}}
{"token": ["C0063041#ent", "<e1>", "may", "be", "a", "pyrimidine", "synthesis", "inhibitor", ",", "although", "C1268567#ent", "<e2>", "also", "be", "part", "of", "its", "mechanism", "of", "action", "."], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [10, 11]}}
{"token": ["A", "number", "of", "studies", "demonstrate", "that", "C0063041#ent", "<e1>", "functions", "both", "as", "a", "pyrimidine", "synthesis", "inhibitor", "and", "as", "a", "C1268567#ent", "<e2>"], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [18, 19]}}
{"token": ["Severe", "C0020538#ent", "<e1>", "patients", "with", "transplanted", "kidney", "a", "particular", "risk", "factor", "development", "of", "C3854173#ent", "<e2>", "iACE", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [13, 14]}}
{"token": ["To", "assess", "prognostic", "implications", "of", "controlled", "and", "uncontrolled", "C0020538#ent", "<e1>", "AH", ")", "in", "patients", "with", "C3854173#ent", "<e2>", "TRF", ")", "on", "chronic", "hemodialysis", "CHD", ")", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [15, 16]}}
{"token": ["The", "authors", "studied", "the", "duration", "of", "action", "of", "C0042435#ent", "<e1>", "in", "15", "patients", "with", "normal", "renal", "function", "40", "patients", "with", "C1561643#ent", "<e2>", "evaluate", "the", "effect", "of", "secondary", "hyperparathyroidism", "the", "action", "of", "C0042435#ent", "<e1>", "."], "h": {"id": "C0042435", "name": "C0042435#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [20, 21]}}
{"token": ["The", "author", "observed", "complete", "relaxation", "--", "verified", "by", "nerve", "stimulation", "--", "for", "more", "than", "3", "h", "following", "a", "single", "dose", "of", "0.09", "mg/kg", "C0042435#ent", "<e1>", "in", "a", "patient", "with", "C1561643#ent", "<e2>"], "h": {"id": "C0042435", "name": "C0042435#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [29, 30]}}
{"token": ["Since", "many", "of", "these", "enzymes", "represent", "potential", "drug", "targets", "C0005944#ent", "<e1>", "efforts", "were", "initiated", "to", "discover", "C4084937#ent", "<e2>", "mimics", "that", "bind", "to", "AMP-binding", "sites", "with", "high", "affinity", "and", "high", "enzyme", "specificity", "."], "h": {"id": "C0005944", "name": "C0005944#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4084937", "name": "C4084937#ent", "pos": [16, 17]}}
{"token": ["C0039902#ent", "<e1>", "also", "attenuated", "LPS-stimulated", "C1968833#ent", "<e2>", "expression", "by", "using", "immunoblot", "analysis"], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [5, 6]}}
{"token": ["PP", "secretion", "can", "be", "used", ",", "e.g.", "as", "a", "sensitive", "indicator", "of", "C1145628#ent", "<e1>", "patients", "with", "C0011849#ent", "<e2>", "."], "h": {"id": "C1145628", "name": "C1145628#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [16, 17]}}
{"token": ["Further", "investigation", "revealed", "that", "nuclear", "import", "the", "C0246769#ent", "<e1>", "inhibited", "by", "overexpression", "of", "the", "C2827472#ent", "<e2>", "amino", "terminus", "."], "h": {"id": "C0246769", "name": "C0246769#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2827472", "name": "C2827472#ent", "pos": [14, 15]}}
{"token": ["In", "the", "V\u00e5g\u00e5", "study", "C0018681#ent", "<e1>", "epidemiology", ",", "a", "search", "was", "made", "also", "for", "C0009088#ent", "<e2>"], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0009088", "name": "C0009088#ent", "pos": [14, 15]}}
{"token": ["Supporting", "these", "data", ",", "the", "cells", "examined", "expressed", "PTPzeta", ",", "a", "C1419114#ent", "<e1>", "exhibits", "high", "affinity", "to", "both", "midkine", "and", "C1335278#ent", "<e2>", "and", "harbors", "chondroitin", "sulfate", "chains"], "h": {"id": "C1419114", "name": "C1419114#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335278", "name": "C1335278#ent", "pos": [20, 21]}}
{"token": ["PTP", "zeta", "is", "a", "C1419114#ent", "<e1>", "is", "synthesized", "as", "a", "chondroitin", "sulfate", "proteoglycan", "uses", "C1335278#ent", "<e2>", "as", "a", "ligand", "."], "h": {"id": "C1419114", "name": "C1419114#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335278", "name": "C1335278#ent", "pos": [14, 15]}}
{"token": ["These", "siblings", "share", "a", "C1336643#ent", "<e1>", "bearing", "haplotype", "typing", "DQB*0301", ",", "and", "the", "sister", "with", "C0240903#ent", "<e2>", "a", "C1336643#ent", "<e1>", "negative", "haplotype", "carrying", "a", "C4A", "null", "allele", "an", "unusual", "DR-DQA", "combination", "."], "h": {"id": "C1336643", "name": "C1336643#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0240903", "name": "C0240903#ent", "pos": [15, 16]}}
{"token": ["Coexpressed", "C1704467#ent", "<e1>", "abrogated", "these", "effects", "of", "C1335222#ent", "<e2>", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335222", "name": "C1335222#ent", "pos": [7, 8]}}
{"token": ["The", "expression", "of", "C1704467#ent", "<e1>", "and", "Bcl-X(L", ")", "correlated", "with", "that", "of", "C1335222#ent", "<e2>", "in", "breast", "normal", "carcinoma", "cell", "lines", "not", "tissues", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335222", "name": "C1335222#ent", "pos": [12, 13]}}
{"token": ["To", "investigate", "the", "involvement", "of", "C1413109#ent", "<e1>", "in", "regulation", "of", "C1826724#ent", "<e2>", "concentrations", ",", "mu-calpain", "antisense", "oligonucleotides", "added", "to", "L8", "myoblasts"], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [10, 11]}}
{"token": ["Polytrauma", ",", "impaired", "consciousness", ",", "chronic", "airway", "disease", "prior", "surgery", "and", "C0007222#ent", "<e1>", "significantly", "related", "to", "the", "occurrence", "of", "C0205721#ent", "<e2>", "LRTI", "."], "h": {"id": "C0007222", "name": "C0007222#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0205721", "name": "C0205721#ent", "pos": [19, 20]}}
{"token": ["Two", "genes", "encoding", "different", "acetylcholinesterases", "(", "C0001044#ent", "<e1>", ")", "were", "successfully", "cloned", "from", "2", "species", "of", "C0885100#ent", "<e2>", ",", "Rhopalosiphum", "padi", "L.", ")", "and", "Sitobion", "avenae", "F.", ")", "."], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0885100", "name": "C0885100#ent", "pos": [16, 17]}}
{"token": ["While", "additional", "potential", "metabolites", "of", "C0066685#ent", "<e1>", "were", "suggested", "by", "computer-modeling", ",", "C0209137#ent", "<e2>", "was", "the", "sole", "metabolite", "detected", "after", "microsomal", "treatment", "."], "h": {"id": "C0066685", "name": "C0066685#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0209137", "name": "C0209137#ent", "pos": [12, 13]}}
{"token": ["However", ",", "these", "C1517132#ent", "<e1>", "some", "degree", "of", "selectivity", "towards", "C0024530#ent", "<e2>", "parasites", "since", "there", "was", "no", "cytotoxic", "activity", "at", "70", "-", "80", "microM."], "h": {"id": "C1517132", "name": "C1517132#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [10, 11]}}
{"token": ["The", "pMP23", "and", "MP28", "stably", "accumulated", "in", "the", "yeast", "vacuolar", "membrane", "the", "proteins", "were", "expressed", "in", "the", "proteinase", "A-deficient", "strain", "C1419064#ent", "<e1>", ")", ",", "which", "lacks", "the", "activities", "of", "C0379099#ent", "<e2>"], "h": {"id": "C1419064", "name": "C1419064#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [29, 30]}}
{"token": ["C1419064#ent", "<e1>", "mutants", "are", "defective", "in", "the", "activation", "of", "many", "C0379099#ent", "<e2>", "including", "proteinase", "B.", "We", "have", "expressed", "a", "C1419064#ent", "<e1>", "mutation", "which", "directs", "the", "accumulation", "of", "pro-proteinase", "A", "with", "a", "defective", "active", "site"], "h": {"id": "C1419064", "name": "C1419064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [10, 11]}}
{"token": ["Based", "on", "our", "observations", ",", "we", "propose", "a", "model", "whereby", "inactive", "precursor", "molecules", "from", "the", "C1419064#ent", "<e1>", "self-activate", "within", "the", "yeast", "vacuole", "subsequently", "activate", "other", "C0379099#ent", "<e2>"], "h": {"id": "C1419064", "name": "C1419064#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [25, 26]}}
{"token": ["This", "study", "compared", "the", "antiarrhythmic", "effects", "ibutilide", "with", "the", "class", "IA", "agent", "C0033216#ent", "<e1>", "in", "humans", "during", "AFL", "and", "C0004238#ent", "<e2>", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [19, 20]}}
{"token": ["The", "use", "of", "prophylactic", "beta-blockers", "C0033216#ent", "<e1>", "reduces", "the", "incidence", "of", "C0004238#ent", "<e2>", "whereas", "digoxin", ",", "verapamil", ",", "and", "amiodarone", "appear", "less", "effective", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [11, 12]}}
{"token": ["For", "C4084734#ent", "<e1>", ",", "EBV", "was", "associated", "with", "all", "cases", "with", "C1334863#ent", "<e2>", "+", "phenotype", "and", "cases", "with", "polymorphic", "reticulosis", "morphology", "with", "CD56-", "phenotype", "."], "h": {"id": "C4084734", "name": "C4084734#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [11, 12]}}
{"token": ["All", "EBV-positive", "C4084734#ent", "<e1>", "showed", "coexpression", "of", "natural", "killer(NK", ")", "cell", "phenotype", "C1334863#ent", "<e2>", "and", "CD2", "."], "h": {"id": "C4084734", "name": "C4084734#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [12, 13]}}
{"token": ["Although", "positive", "treatment", "results", "have", "been", "described", ",", "it", "is", "not", "known", "whether", "this", "therapy", "C2712370#ent", "<e1>", "the", "natural", "course", "eyes", "with", "neovascular", "age-related", "macular", "degeneration", "C1412379#ent", "<e2>", ")", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412379", "name": "C1412379#ent", "pos": [26, 27]}}
{"token": ["The", "choice", "between", "C3811061#ent", "<e1>", "and", "MgCl2", "depends", "on", "whether", "blood", "without", "C3536711#ent", "<e2>", "or", "ACD", "blood", "is", "employed", "."], "h": {"id": "C3811061", "name": "C3811061#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [12, 13]}}
{"token": ["C1413666#ent", "<e1>", "TAFI", ")", "may", "contribute", "to", "a", "C0398623#ent", "<e2>", "and", "therefore", "we", "were", "interested", "in", "the", "role", "of", "TAFI", "in", "SVT", "."], "h": {"id": "C1413666", "name": "C1413666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [8, 9]}}
{"token": ["C1420740#ent", "<e1>", "should", "be", "considered", "an", "C1254351#ent", "<e2>", "gastric", "cancer"], "h": {"id": "C1420740", "name": "C1420740#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [6, 7]}}
{"token": ["Under", "these", "conditions", ",", "the", "migration", "times", "were", "found", "to", "be", "5.174min", "for", "C1417826#ent", "<e1>", ",", "5.513min", "for", "CAF", ",", "7.195min", "for", "C0812246#ent", "<e2>", ",", "and", "9.366min", "for", "PRO", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [22, 23]}}
{"token": ["Moreover", ",", "C1417826#ent", "<e1>", "agonists", "significantly", "induced", "the", "C0812246#ent", "<e2>", "secretion", "from", "HMC-1", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [8, 9]}}
{"token": ["Recombinant", "human", "C1418882#ent", "<e1>", "and", "SP-A", "isolated", "from", "human", "C0034050#ent", "<e2>", "studied", "."], "h": {"id": "C1418882", "name": "C1418882#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034050", "name": "C0034050#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "the", "relationship", "between", "genital", "and", "C0015403#ent", "<e1>", "adenovirus", ",", "the", "part", "played", "by", "C2314882#ent", "<e2>", "its", "dissemination", ",", "and", "the", "clinical", "symptoms", "may", "produce", "need", "further", "study", "."], "h": {"id": "C0015403", "name": "C0015403#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [15, 16]}}
{"token": ["C1522405#ent", "<e1>", "(IL-2)-induced", "generation", "of", "non-major", "histocompatibility", "complex", "killer", "cells", "human", "cord", "blood", "lymphocytes", "C0008163#ent", "<e2>", ")", "was", "investigated", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008163", "name": "C0008163#ent", "pos": [14, 15]}}
{"token": ["Herpes", "simplex", "virus", "infections", "well", "known", "complications", "of", "various", "C0018567#ent", "<e1>", "and", "have", "also", "been", "reported", "in", "acantholytic", "diseases", "C0341009#ent", "<e2>", "Darier's", "Hailey-Hailey", "diseases"], "h": {"id": "C0018567", "name": "C0018567#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0341009", "name": "C0341009#ent", "pos": [19, 20]}}
{"token": ["It", "has", "been", "recently", "evaluated", ",", "with", "varying", "results", ",", "in", "several", "C0018567#ent", "<e1>", "such", "as", "C0341009#ent", "<e2>"], "h": {"id": "C0018567", "name": "C0018567#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0341009", "name": "C0341009#ent", "pos": [16, 17]}}
{"token": ["To", "lead", "ophthalmologists", "to", "consider", "Cogan", "syndrome", "managing", "a", "patient", "presenting", "with", "C0022568#ent", "<e1>", "or", "other", "ocular", "inflammation", "by", "C0018784#ent", "<e2>"], "h": {"id": "C0022568", "name": "C0022568#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "C0032574#ent", "<e1>", "(", "PPP", ")", ",", "an", "inhibitor", "of", "C3540754#ent", "<e2>", "(", "PG", ")", ",", "upon", "the", "IDT", "and", "frequency", "of", "different", "tubal", "segments", ",", "were", "also", "explored", "."], "h": {"id": "C0032574", "name": "C0032574#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [12, 13]}}
{"token": ["C0032574#ent", "<e1>", "antagonized", "the", "excitatory", "effects", "of", "C3540754#ent", "<e2>", "in", "both", "human", "and", "guinea-pig", "muscle", "preparations", ",", "but", "it", "caused", "stimulation", "of", "the", "rat", "fundus.5", "."], "h": {"id": "C0032574", "name": "C0032574#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [7, 8]}}
{"token": ["C0032911#ent", "<e1>", "(", "PZQ", ")", ",", "a", "broad", "spectrum", "C0003158#ent", "<e2>", "is", "extensively", "metabolized", "in", "the", "liver", ",", "yielding", "mainly", "monohydroxylated", "and", "dihydroxylated", "phase-I-metabolites", "."], "h": {"id": "C0032911", "name": "C0032911#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003158", "name": "C0003158#ent", "pos": [9, 10]}}
{"token": ["2G4", "did", "not", "react", "with", "lactoperoxidase", ",", "horseradish", "peroxidase", "human", "C0027021#ent", "<e1>", "or", "with", "porcine", "C0021965#ent", "<e2>", "or", "with", "human", "thyroglobulin"], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021965", "name": "C0021965#ent", "pos": [15, 16]}}
{"token": ["Myeloperoxidase", "is", "a", "member", "of", "a", "family", "of", "homologous", "mammalian", "C0027021#ent", "<e1>", "that", "includes", "C0021965#ent", "<e2>", "eosinophil", "peroxidase", "lactoperoxidase", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021965", "name": "C0021965#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "EV", "C0042749#ent", "<e1>", "were", "younger", "and", "less", "likely", "to", "have", "C0018799#ent", "<e2>", "a", "travel", "history", "P<0.05", ")", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [12, 13]}}
{"token": ["While", "the", "C1335192#ent", "<e1>", "gene", "dosage", "unaffected", ",", "the", "C1413591#ent", "<e2>", "found", "to", "be", "deleted", "and", "triplicated", ",", "respectively", "."], "h": {"id": "C1335192", "name": "C1335192#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413591", "name": "C1413591#ent", "pos": [9, 10]}}
{"token": ["Expression", "experiments", "that", "both", "C0287531#ent", "<e1>", "and", "a", "C0669365#ent", "<e2>", "active", "mutant", "of", "calcineurin", "A", "impaired", "carbachol-induced", "upregulation", "of", "AP-1", "activity", "."], "h": {"id": "C0287531", "name": "C0287531#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}}
{"token": ["Lentiviral-mediated", "expression", "of", "either", "MAP", "kinase", "phosphatase-1", "C0287531#ent", "<e1>", ")", "or", "a", "C0669365#ent", "<e2>", "active", "mutant", "of", "calcineurin", "A", "inhibited", "Egr-1", "biosynthesis", "following", "carbachol", "stimulation", ",", "indicating", "that", "these", "phosphatases", "function", "shut-off", "devices", "of", "muscarinic", "acetylcholine", "receptor", "signaling"], "h": {"id": "C0287531", "name": "C0287531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}}
{"token": ["Spontaneously", "hypertensive", "rats", "(", "SHR", ")", "given", "streptozotocin", "(", "C1539862#ent", "<e1>", ")", "neonatally", "developed", "C0598428#ent", "<e2>", "overt", "hyperglycemia", "after", "the", "onset", "of", "puberty", "."], "h": {"id": "C1539862", "name": "C1539862#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0598428", "name": "C0598428#ent", "pos": [14, 15]}}
{"token": ["C1425056#ent", "<e1>", "is", "a", "member", "of", "the", "Rho", "family", "small", "C0086376#ent", "<e2>", "has", "previously", "been", "implicated", "in", "the", "regulation", "of", "insulin-stimulated", "GLUT4", "translocation", "in", "adipocytes", "."], "h": {"id": "C1425056", "name": "C1425056#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["All", "in", "all", "these", "results", "document", "a", "novel", "relationship", "between", "C1413702#ent", "<e1>", "activation", "and", "differentiation-related", "apoptotic", "cell", "death", "assign", "a", "role", "to", "C1120843#ent", "<e2>", "determining", "these", "events", "in", "K562", "erythroleukemia", "cells", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [22, 23]}}
{"token": ["These", "results", "suggest", "that", "PE", "stimulates", "phosphorylation", "and", "DNA", "binding", "activity", "C1413702#ent", "<e1>", "in", "adult", "rat", "ventricular", "myocytes", "multiple", "signaling", "pathways", "ERK1/2", ",", "C1120843#ent", "<e2>", "MSK1", "and", "PKA", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [23, 24]}}
{"token": ["Spinal", "muscular", "atrophy", "C0026847#ent", "<e1>", ")", ",", "a", "clinically", "and", "C1516876#ent", "<e2>", "heterogeneous", "group", "of", "neuromuscular", "diseases", "is", "a", "disorder", "of", "motor", "neurones", "by", "degeneration", "of", "spinal", "cord", "anterior", "horn", "cells", "muscular", "atrophy"], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [10, 11]}}
{"token": ["A", "tendency", "toward", "nonuniform", "territorial", "C0026847#ent", "<e1>", "prevalence", "is", "observed", "in", "C1516876#ent", "<e2>", "subdivided", "populations", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [11, 12]}}
{"token": ["Intracerebroventricular", "treatment", "of", "C1453952#ent", "<e1>", "rats", "with", "a", "specific", "inhibitor", "of", "C0248813#ent", "<e2>", "SP600125", ")", "restores", "insulin", "signaling", "leads", "to", "a", "reduced", "caloric", "intake", "weight", "loss"], "h": {"id": "C1453952", "name": "C1453952#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [11, 12]}}
{"token": ["Infection", "with", "C0162667#ent", "<e1>", "parasites", "is", "known", "to", "increase", "the", "level", "of", "C4085186#ent", "<e2>", "the", "jejunum", "and", "serum", "in", "mice", "."], "h": {"id": "C0162667", "name": "C0162667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4085186", "name": "C4085186#ent", "pos": [12, 13]}}
{"token": ["Evaluation", "of", "C1333673#ent", "<e1>", "secretion", "may", "be", "useful", "in", "evaluating", "C0878787#ent", "<e2>", "this", "group", "of", "patients", ",", "and", "the", "usefulness", "of", "GH", "therapy", "be", "investigated", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0878787", "name": "C0878787#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "the", "effects", "of", "growth", "hormone", "C1333673#ent", "<e1>", ")", "on", "the", "reversal", "of", "C0878787#ent", "<e2>", "uremia", ",", "recombinant", "human", "GH", "(", "rhGH", ")", "was", "administered", "to", "rats", "with", "chronic", "renal", "failure", "CRF", ")", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0878787", "name": "C0878787#ent", "pos": [14, 15]}}
{"token": ["An", "Approvable", "letter", "was", "issued", "for", "Lyrica", "(", "C0657912#ent", "<e1>", ")", "for", "the", "treatment", "of", "post-herpetic", "neuralgia", "painful", "diabetic", "neuropathy", "and", "partial", "C0036572#ent", "<e2>", "in", "adults", "."], "h": {"id": "C0657912", "name": "C0657912#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [22, 23]}}
{"token": ["C0657912#ent", "<e1>", "is", "approved", "in", "US", "and", "Europe", "for", "adjunctive", "therapy", "partial", "C0036572#ent", "<e2>", "in", "adults", ",", "and", "also", "has", "been", "approved", "for", "the", "treatment", "of", "pain", "from", "diabetic", "neuropathy", "post-herpetic", "neuralgia", "adults", "."], "h": {"id": "C0657912", "name": "C0657912#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}}
{"token": ["Two", "open", "reading", "frames", "the", "C0025627#ent", "<e1>", "a", "hitherto", "unknown", "C0017337#ent", "<e2>", "(", "maoC", ")", ",", "were", "found", "."], "h": {"id": "C0025627", "name": "C0025627#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["Chemically", "biotinylated", "C1415382#ent", "<e1>", "was", "readily", "imported", "into", "C3179066#ent", "<e2>", "."], "h": {"id": "C1415382", "name": "C1415382#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [8, 9]}}
{"token": ["The", "relation", "was", "similar", "in", "patients", "with", "C0878544#ent", "<e1>", "11", ")", ",", "and", "in", "those", "with", "C0026265#ent", "<e2>", "26", ")", ",", "hypertension", "(", "five", ")", ",", "and", "coronary", "artery", "disease", "four", ")", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026265", "name": "C0026265#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "describe", "a", "case", "of", "APS", "with", "the", "unusual", "combination", "of", "type", "1", "diabetes", "C0271738#ent", "<e1>", "growth", "hormone", "deficiency", "and", "primary", "hypothyroidism", "associated", "with", "lethal", "C0264856#ent", "<e2>"], "h": {"id": "C0271738", "name": "C0271738#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0264856", "name": "C0264856#ent", "pos": [26, 27]}}
{"token": ["We", "investigated", "the", "role", "of", "C0907532#ent", "<e1>", "eNOS", ")", "in", "the", "remnant", "kidney", "model", "of", "C1561643#ent", "<e2>", "by", "using", "eNOS-deficient", "(", "eNOS-/-", ")", "and", "wild-type", "mice"], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "whether", "polymorphism", "of", "intron", "4", "the", "C0907532#ent", "<e1>", "ecNOS", ")", "gene", "is", "related", "to", "the", "progression", "of", "C1561643#ent", "<e2>"], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [19, 20]}}
{"token": ["Asymmetric", "dimethylarginine", "ADMA", ")", ",", "an", "endogenous", "inhibitor", "of", "C0907532#ent", "<e1>", "a", "proposed", "cardiovascular", "risk", "factor", "is", "elevated", "in", "C1561643#ent", "<e2>", "CKD", ")", "."], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [19, 20]}}
{"token": ["Activation", "of", "this", "C0031727#ent", "<e1>", "precedes", "and", "may", "occur", "upstream", "from", "C1565427#ent", "<e2>", "phosphorylation", ",", "although", "the", "nature", "of", "the", "interaction", "between", "these", "2", "enzymes", "remains", "obscure", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [11, 12]}}
{"token": ["At", "least", "two", "C0031727#ent", "<e1>", ",", "a", "novel", "tyrosine", "kinase", "focal", "adhesion", "kinase", "C1565427#ent", "<e2>", ")", ",", "and", "protein", "kinase", "C", "PKC", ")", ",", "are", "activated", "by", "integrin-mediated", "cell", "attachment", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [13, 14]}}
{"token": ["Severe", "C0035222#ent", "<e1>", "SARS", ")", "is", "a", "C0035204#ent", "<e2>", "by", "a", "newly", "found", "virus", ",", "called", "SARS", "coronavirus", "."], "h": {"id": "C0035222", "name": "C0035222#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [7, 8]}}
{"token": ["Clinical", "disorders", "can", "worsen", "cerebral", "blood", "flow", "such", "as", "head", "injury", "coronary", "artery", "disease", "cerebrovascular", "ischemia", "the", "presence", "of", "C0052201#ent", "<e1>", "increase", "the", "risk", "of", "C0002395#ent", "<e2>"], "h": {"id": "C0052201", "name": "C0052201#ent", "pos": [19, 20]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [25, 26]}}
{"token": ["The", "association", "of", "C0052201#ent", "<e1>", "the", "age", "of", "onset", "of", "common", "C0002395#ent", "<e2>", "AD", ")", "was", "originally", "reported", "in", "three", "1993", "papers", "from", "the", "Duke", "ADRC", "(", "Alzheimer's", "Disease", "Research", "Center", "group", "."], "h": {"id": "C0052201", "name": "C0052201#ent", "pos": [3, 4]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [11, 12]}}
{"token": ["The", "presence", "of", "the", "C0052201#ent", "<e1>", "been", "identified", "as", "a", "major", "risk", "factor", "C0002395#ent", "<e2>"], "h": {"id": "C0052201", "name": "C0052201#ent", "pos": [4, 5]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [13, 14]}}
{"token": ["The", "guidelines", "propose", "long-acting", "Ca", "antagonists", "C0003015#ent", "<e1>", "the", "first", "choice", "of", "C1254351#ent", "<e2>", "for", "the", "treatment", "of", "uncomplicated", "hypertension", "in", "the", "elderly", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "hexamestane", "was", "also", "effective", "in", "patients", "pretreated", "with", "C0003015#ent", "<e1>", "of", "which", "the", "C1254351#ent", "<e2>", "aminoglutethimide", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["The", "only", "treatment", "modality", "which", "controlled", "the", "C0024523#ent", "<e1>", "was", "immunosuppression", "with", "intravenous", "high", "dose", "C0360556#ent", "<e2>", "and", "oral", "methotrexate", "maintenance", "therapy"], "h": {"id": "C0024523", "name": "C0024523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0360556", "name": "C0360556#ent", "pos": [15, 16]}}
{"token": ["C0165519#ent", "<e1>", "MMP-9", ")", "is", "capable", "of", "degrading", "C0013765#ent", "<e2>", ",", "whereas", "tissue", "inhibitor", "metalloproteinase-1", "(", "TIMP-1", ")", "can", "inhibit", "MMP-9", "activity"], "h": {"id": "C0165519", "name": "C0165519#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [8, 9]}}
{"token": ["The", "unique", "pattern", "for", "nasal", "cartilage", "intense", "staining", "for", "C0165519#ent", "<e1>", "collagen", "X", "whereas", "articular", "cartilage", "negative", "for", "C0013765#ent", "<e2>", "(", "interterritorially", ")", "and", "only", "weakly", "positive", "for", "collagen", "Types", "V", "VI", "."], "h": {"id": "C0165519", "name": "C0165519#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [18, 19]}}
{"token": ["We", "have", "employed", "C0907533#ent", "<e1>", "gene", "deletion", "elucidate", "the", "role", "of", "C3538757#ent", "<e2>", "in", "vivo"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538757", "name": "C3538757#ent", "pos": [11, 12]}}
{"token": ["We", "have", "isolated", "the", "C0058361#ent", "<e1>", "DAP", "BI", ")", "C0079429#ent", "<e2>", "from", "the", "plasmid", "library", "of", "Pseudomonas", "sp.", "WO24", "chromosomal", "DNA", "the", "enzymatic", "plate", "assay", "a", "chromogenic", "substrate", "."], "h": {"id": "C0058361", "name": "C0058361#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["Nine", "patients", "with", "heterozygous", "familial", "C0020443#ent", "<e1>", "were", "treated", "for", "eight", "weeks", "with", "either", "40", "mg", "C0085542#ent", "<e2>", "or", "placebo", "under", "double", "blind", "conditions"], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0085542", "name": "C0085542#ent", "pos": [16, 17]}}
{"token": ["C0042523#ent", "<e1>", "is", "a", "C3539994#ent", "<e2>", "antagonises", "calcium", "influx", "the", "slow", "channels", "vascular", "smooth", "muscle", "cardiac", "cell", "membranes"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539994", "name": "C3539994#ent", "pos": [4, 5]}}
{"token": ["Deletion", "of", "p16", "was", "assessed", "in", "a", "multiplex", "PCR", "amplified", "a", "405", "bp", "fragment", "from", "exon", "2", "the", "C0525037#ent", "<e1>", "and", "a", "242", "bp", "fragment", "of", "the", "C1412481#ent", "<e2>", "served", "as", "an", "internal", "control"], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [27, 28]}}
{"token": ["Cotransfection", "assays", "in", "the", "human", "hepatoma", "HepG2", "cell", "line", "that", "FoxM1B", "protein", "stimulated", "expression", "of", "both", "the", "C1332695#ent", "<e1>", "cyclin", "D1", "promoters", ",", "suggesting", "that", "these", "C1413171#ent", "<e2>", "a", "direct", "FoxM1B", "transcriptional", "target", "."], "h": {"id": "C1332695", "name": "C1332695#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413171", "name": "C1413171#ent", "pos": [26, 27]}}
{"token": ["The", "results", "of", "in", "vitro", "studies", "indicated", "that", "ARIPIPRAZOLE", ",", "a", "newly", "developed", "C0040615#ent", "<e1>", ",", "is", "mainly", "metabolized", "by", "the", "human", "cytochrome", "P450", "isozymes", "C1142644#ent", "<e2>", "and", "CYP2D6", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [25, 26]}}
{"token": ["Remarkable", "progress", "has", "been", "made", "recently", "in", "identifying", "a", "new", "C1517488#ent", "<e1>", "to", "the", "capsaicin", "(", "vanilloid", ")", "receptor", ",", "C1421467#ent", "<e2>", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421467", "name": "C1421467#ent", "pos": [20, 21]}}
{"token": ["Cholesteryl", "ester", "storage", "disease", "CESD", ")", "and", "Wolman", "disease", "both", "C3899988#ent", "<e1>", "associated", "with", "reduced", "activity", "and", "genetic", "defects", "C0544512#ent", "<e2>", "LAL", ")", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0544512", "name": "C0544512#ent", "pos": [19, 20]}}
{"token": ["To", "compare", "the", "results", "of", "endoscopic", "surgical", "decompression", "carpal", "tunnel", "release", "C1413085#ent", "<e1>", ")", "with", "open", "C1413085#ent", "<e1>", "in", "patients", "with", "C0007286#ent", "<e1>", "CTS", ")", "."], "h": {"id": "C1413085", "name": "C1413085#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [21, 22]}}
{"token": ["C1567966#ent", "<e1>", "are", "agonists", "at", "5-HT1B", "and", "C1415805#ent", "<e2>", "(", "where", "5-HT", "is", "5-hydroxytryptamine", ";", "serotonin", ")", "receptors", "and", "cause", "vasoconstriction", "of", "isolated", "blood", "vessels"], "h": {"id": "C1567966", "name": "C1567966#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415805", "name": "C1415805#ent", "pos": [7, 8]}}
{"token": ["Improvements", "in", "C0035258#ent", "<e1>", "symptoms", "have", "been", "maintained", "in", "the", "long", "term", "C1700683#ent", "<e2>", ",", "according", "to", "the", "3-year", "results", "of", "an", "open-label", "extension", "trial", "."], "h": {"id": "C0035258", "name": "C0035258#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C1700683", "name": "C1700683#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "C4082284#ent", "<e1>", "by", "oncogenic", "Abl", "was", "effectively", "inhibited", "by", "C1333707#ent", "<e2>", "with", "mutations", "in", "either", "its", "SH2", "or", "SH3", "domain", "by", "Crk-1", "with", "an", "SH3", "domain", "mutation", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333707", "name": "C1333707#ent", "pos": [11, 12]}}
{"token": ["Mammalian", "C0255652#ent", "<e1>", "is", "a", "protein", "kinase", "as", "the", "catalytic", "subunit", "cyclin-dependent", "kinase", "C0031727#ent", "<e2>", "and", "as", "an", "essential", "component", "of", "the", "transcription", "factor", "TFIIH", "is", "involved", "in", "transcription", "initiation", "and", "DNA", "repair"], "h": {"id": "C0255652", "name": "C0255652#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["Human", "translationally", "controlled", "tumor", "protein", "C3538773#ent", "<e1>", ")", "is", "a", "growth-related", ",", "C1413053#ent", "<e2>"], "h": {"id": "C3538773", "name": "C3538773#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413053", "name": "C1413053#ent", "pos": [12, 13]}}
{"token": ["Fecal", "harmful", "C3541394#ent", "<e1>", "such", "as", "beta-glucosidase", ",", "beta-glucuronidase", ",", "tryptophanase", "and", "C0041945#ent", "<e2>", ",", "were", "effectively", "inhibited", "during", "the", "administration", "of", "the", "B.", "longum", "SPM1205", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041945", "name": "C0041945#ent", "pos": [12, 13]}}
{"token": ["We", "reanalysed", "available", "C1417750#ent", "<e1>", "data", "with", "C0000970#ent", "<e2>", "in", "relation", "to", "the", "magnitude", "of", "surgical", "injury"], "h": {"id": "C1417750", "name": "C1417750#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [7, 8]}}
{"token": ["The", "patients", "were", "allocated", "randomly", "to", "one", "of", "four", "groups", "and", "received", "differing", "doses", "of", "fentanyl", "and", "C0022860#ent", "<e1>", "to", "vary", "the", "range", "of", "sensitivities", "to", "the", "hypotensive", "action", "C0022180#ent", "<e2>", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [29, 30]}}
{"token": ["C1420317#ent", "<e1>", "substituted", "for", "LSD", "and", "both", "were", "blocked", "by", "C0032036#ent", "<e2>", "and", "pirenperone", "."], "h": {"id": "C1420317", "name": "C1420317#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032036", "name": "C0032036#ent", "pos": [10, 11]}}
{"token": ["Ankylosing", "spondylitis", "AS", ")", "is", "a", "frequent", "C1290884#ent", "<e1>", "prototype", "of", "the", "Spondyloarthitides", "(", "C1420002#ent", "<e2>", ")", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [14, 15]}}
{"token": ["All", "patients", "had", "extensive", "C0867389#ent", "<e1>", "diffuse", "or", "localized", "sclerodermoid", "GVHD", "and", "C0043349#ent", "<e2>", "."], "h": {"id": "C0867389", "name": "C0867389#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0043349", "name": "C0043349#ent", "pos": [12, 13]}}
{"token": ["C1708803#ent", "<e1>", ",", "a", "brain-specific", "JNK", "C0597298#ent", "<e2>", ",", "is", "activated", "under", "oxidative", "and", "heat", "stresses", "and", "inhibition", "of", "Pin1", "by", "Pin1", "short", "interference", "RNA", "DN-Pin1", "inhibits", "this", "pathway", "."], "h": {"id": "C1708803", "name": "C1708803#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [6, 7]}}
{"token": ["The", "present", "study", "shows", "that", "C0966482#ent", "<e1>", "can", "inhibit", "(-)-apomorphine-induced", "behaviours", "in", "C1334982#ent", "<e2>", "doses", "that", "do", "not", "cause", "EPS", "."], "h": {"id": "C0966482", "name": "C0966482#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334982", "name": "C1334982#ent", "pos": [12, 13]}}
{"token": ["Additional", "pharmacological", "inhibitor", "and", "small", "interference", "experiments", "also", "demonstrated", "that", "C0257535#ent", "<e1>", "JNK", ",", "and", "phosphatidylinositol", "3-kinase", "C1709402#ent", "<e2>", "signaling", "pathways", "also", "involved", "in", "the", "TGF-beta1-stimulated", "increase", "in", "hAT(1)R", "density", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [17, 18]}}
{"token": ["The", "staurosporine-induced", "apoptosis", "is", "positively", "regulated", "by", "PKC", ",", "negatively", "regulated", "by", "C0257535#ent", "<e1>", "p44/42", "MAPK", "and", "C1709402#ent", "<e2>", "the", "caspase", "cascade", "and", "negatively", "regulated", "by", "PKA", "without", "regulation", "of", "caspase", "activation"], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [17, 18]}}
{"token": ["C1527336#ent", "<e1>", "SS", ")", "is", "a", "C0004364#ent", "<e2>", "which", "lymphocytic", "infiltration", "the", "lacrimal", "and", "salivary", "glands", "the", "hallmark", "of", "disease", "diagnosis"], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [6, 7]}}
{"token": ["Male", "rainbow", "trout", "C0669372#ent", "<e1>", "were", "cultured", "as", "C0872351#ent", "<e2>", "in", "pure", "M199", "medium", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [8, 9]}}
{"token": ["Following", "the", "selective", "destruction", "of", "catecholaminergic", "nerve", "terminals", "intracerebral", "administration", "6-hydroxydopamine", ",", "a", "marked", "reduction", "in", "the", "incorporation", "of", "C0011685#ent", "<e1>", ",", "but", "not", "of", "C1413693#ent", "<e2>", ",", "was", "evident", "in", "all", "brain", "areas", "investigated", "."], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1413693", "name": "C1413693#ent", "pos": [25, 26]}}
{"token": ["These", "results", "further", "strengthen", "the", "suggestion", "that", "the", "concentration", "of", "C1540067#ent", "<e1>", "is", "the", "critical", "factor", "the", "regulation", "of", "virulence", "in", "C0013371#ent", "<e2>", "."], "h": {"id": "C1540067", "name": "C1540067#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013371", "name": "C0013371#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "these", "data", "highlight", "a", "novel", "role", "for", "C1705297#ent", "<e1>", "in", "signaling", "from", "v-Abl", "to", "C1425569#ent", "<e2>", "."], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [16, 17]}}
{"token": ["Signaling", "from", "PI3Kgamma", "to", "MAPK", "appears", "to", "require", "in", "our", "murine", "cellular", "system", "tyrosine", "kinase", "still", "not", "characterized", ")", ",", "C1705297#ent", "<e1>", ",", "Grb2", ",", "Sos", ",", "Ras", "and", "C1425569#ent", "<e2>", "."], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [29, 30]}}
{"token": ["C0001962#ent", "<e1>", "has", "been", "implicated", "as", "a", "risk", "factor", "C1449563#ent", "<e2>", "DCM", ")", ",", "but", "a", "causal", "relation", "has", "not", "been", "established", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1449563", "name": "C1449563#ent", "pos": [9, 10]}}
{"token": ["Harmful", "effects", "C0001962#ent", "<e1>", "on", "the", "cardiovascular", "system", "C1449563#ent", "<e2>", "systemic", "hypertension", "cerebral", "vascular", "incidents"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1449563", "name": "C1449563#ent", "pos": [8, 9]}}
{"token": ["After", "an", "oral", "fat", "C0017245#ent", "<e1>", "inhibits", "the", "increase", "in", "serum", "cholesterol", "partly", "prevents", "postprandial", "C0020557#ent", "<e2>", "."], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [15, 16]}}
{"token": ["Both", "clofibrate", "and", "C0017245#ent", "<e1>", "treatment", "effectively", "decreased", "the", "fructose-induced", "C0020557#ent", "<e2>", "and", "increased", "the", "liver", "to", "body", "weight", "ratio"], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [10, 11]}}
{"token": ["We", "concluded", "that", "the", "opening", "of", "mitoK(ATP", ")", "channels", "contributes", "to", "either", "activation", "of", "C2932861#ent", "<e1>", "or", "the", "infarct", "size-limiting", "effect", "via", "activation", "of", "C3539645#ent", "<e2>", "in", "canine", "hearts", "."], "h": {"id": "C2932861", "name": "C2932861#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [24, 25]}}
{"token": ["At", "100", "microM", ",", "C0055699#ent", "<e1>", "inhibited", "the", "release", "of", "C0059407#ent", "<e2>", "macrophage", "N-acetyl-beta-D-glucosaminidase", "only", "19.5", "and", "25.6", "%", ",", "respectively", "."], "h": {"id": "C0055699", "name": "C0055699#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059407", "name": "C0059407#ent", "pos": [10, 11]}}
{"token": ["Whether", "the", "high", "C0066083#ent", "<e1>", "and", "rather", "low", "C1134446#ent", "<e2>", "activity", "will", "lead", "to", "an", "accumulation", "of", "reactive", "epoxides", "derived", "from", "lindane", "remains", "to", "be", "clarified", "."], "h": {"id": "C0066083", "name": "C0066083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [8, 9]}}
{"token": ["A", "three-year-old", "child", "affected", "by", "glycogen", "storage", "disease", "C0029438#ent", "<e1>", ")", "type", "Ia", "presented", "with", "acute", "hemiplegia", "secondary", "to", "C2931384#ent", "<e2>"], "h": {"id": "C0029438", "name": "C0029438#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2931384", "name": "C2931384#ent", "pos": [19, 20]}}
{"token": ["Nonetheless", ",", "a", "recent", "study", "has", "reported", "an", "association", "between", "specific", "alleles", "of", "C1421376#ent", "<e1>", "and", "familial", "combined", "C0020473#ent", "<e2>", ",", "a", "common", "disorder", "that", "substantially", "increases", "the", "risk", "of", "premature", "atherosclerotic", "cardiovascular", "disease"], "h": {"id": "C1421376", "name": "C1421376#ent", "pos": [13, 14]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [18, 19]}}
{"token": ["C0162429#ent", "<e1>", "markedly", "reduced", "the", "steady-state", "level", "of", "C1364818#ent", "<e2>", "mRNA", "whereas", "the", "APP", "protein", "remained", "constant", ",", "indicating", "that", "copper", "deficiency", "accelerate", "C1364818#ent", "<e2>", "translation", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [8, 9]}}
{"token": ["C0085752#ent", "<e1>", "was", "conjugated", "to", "an", "IgG1", "monoclonal", "antibody", "for", "human", "C1367456#ent", "<e2>", "a", "dextran", "bridge", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367456", "name": "C1367456#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "glyburide", "(", "C0017628#ent", "<e1>", ")", "treatment", "on", "the", "C0669516#ent", "<e2>", "SOD", ")", "activity", "of", "diabetic", "rats", "has", "been", "studied", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [11, 12]}}
{"token": ["Because", "mutations", "in", "ion", "channel", "genes", "been", "recognized", "as", "an", "important", "factor", "in", "the", "etiology", "of", "abnormal", "neuronal", "excitability", ",", "C1416601#ent", "<e1>", "is", "an", "interesting", "candidate", "gene", "for", "C4281785#ent", "<e2>", "linked", "to", "8q24", "."], "h": {"id": "C1416601", "name": "C1416601#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C4281785", "name": "C4281785#ent", "pos": [28, 29]}}
{"token": ["First", ",", "C1415549#ent", "<e1>", "bound", "to", "and", "was", "phosphorylated", "by", "cyclin", "A-", "and", "C0108855#ent", "<e2>", "in", "vitro", "an", "RXL-dependent", "manner", "."], "h": {"id": "C1415549", "name": "C1415549#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0108855", "name": "C0108855#ent", "pos": [13, 14]}}
{"token": ["It", "is", "postulated", "that", "the", "effects", "of", "oestradiol", "on", "C0027021#ent", "<e1>", "activity", "are", "mediated", "by", "uterine", "epithelial", "cells", "that", "oestradiol", "effects", "on", "C0009325#ent", "<e2>", "breakdown", "may", "be", "mediated", "by", "another", "cell", "type"], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [22, 23]}}
{"token": ["C57Bl/6", "mice", "immunized", "with", "acetylcholine", "receptors", "AChR", ")", "in", "complete", "C0281643#ent", "<e1>", "cellular", "and", "humoral", "immune", "responses", "AChR.", "They", "developed", "C0030552#ent", "<e2>", "characteristic", "of", "myasthenia", "gravis", "demonstrated", "a", "reduction", "in", "the", "muscle", "AChR", "content", "."], "h": {"id": "C0281643", "name": "C0281643#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [20, 21]}}
{"token": ["Treatment", "of", "C0042721#ent", "<e1>", "patients", "with", "interferon", "alfa", "rybawiryn", "leads", "to", "eradication", "of", "C0694878#ent", "<e2>", "viremia", "in", "50", "%", "cases", "."], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0694878", "name": "C0694878#ent", "pos": [13, 14]}}
{"token": ["China", "is", "an", "area", "of", "high", "endemicity", "for", "C0042721#ent", "<e1>", "and", "the", "molecular", "epidemiological", "investigation", "TT", "virus", "C0694878#ent", "<e2>", ")", "infection", "is", "of", "interest", "."], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0694878", "name": "C0694878#ent", "pos": [17, 18]}}
{"token": ["Recently", ",", "a", "novel", "C0042721#ent", "<e1>", "described", "and", "named", "as", "C0694878#ent", "<e2>", "."], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0694878", "name": "C0694878#ent", "pos": [10, 11]}}
{"token": ["Inhibitors", "of", "phosphoinositide-3-kinase", "(", "C1709402#ent", "<e1>", "completely", "blocked", "activation", "of", "C0164786#ent", "<e2>", "by", "Cu(2+)", "indicating", "a", "requirement", "of", "C1709402#ent", "<e1>", "Cu(2+)-induced", "activation", "of", "C0164786#ent", "<e2>", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [4, 5]}}
{"token": ["In", "contrast", ",", "PD-1", "signaling", "inhibits", "C0164786#ent", "<e1>", "phosphorylation", "by", "preventing", "CD28-mediated", "activation", "of", "phosphatidylinositol", "3-kinase", "C1709402#ent", "<e2>", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [16, 17]}}
{"token": ["These", "encouraging", "results", "suggest", "that", "intravesical", "instillation", "C0134394#ent", "<e1>", "an", "attractive", "alternative", "in", "patients", "with", "a", "C0005697#ent", "<e2>", "who", "are", "either", "unresponsive", "to", "or", "have", "intolerable", "side", "effects", "oral", "medications"], "h": {"id": "C0134394", "name": "C0134394#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [16, 17]}}
{"token": ["Intravesical", "C0134394#ent", "<e1>", "demonstrated", "its", "efficacy", "in", "children", "with", "C0005697#ent", "<e2>", "urinary", "incontinence", "refractory", "to", "oral", "anticholinergic", "agents"], "h": {"id": "C0134394", "name": "C0134394#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [9, 10]}}
{"token": ["One", "component", ",", "designated", "TFIIIC", ",", "contains", "5", "C1305923#ent", "<e1>", "previously", "ascribed", "to", "TFIIIC2", "and", "4", "additional", "C1305923#ent", "<e1>", "that", "correspond", "to", "C1705412#ent", "<e1>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705412", "name": "C1705412#ent", "pos": [22, 23]}}
{"token": ["Nebulized", "C0054201#ent", "<e1>", "has", "been", "used", "successfully", "to", "treat", "C0004096#ent", "<e2>", "exacerbation", ",", "and", "we", "hypothesized", "that", "it", "could", "also", "be", "effective", "for", "exacerbations", "of", "chronic", "obstructive", "pulmonary", "disease", "COPD", ")", "."], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [1, 2]}, "relation": "may_prevent", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [9, 10]}}
{"token": ["A", "transformant", "that", "grew", "on", "minimal", "media", "in", "the", "absence", "of", "C0017789#ent", "<e1>", "was", "isolated", "and", "its", "plasmid", ",", "C1826737#ent", "<e2>", ",", "was", "shown", "to", "encode", "the", "A.", "variabilis", "PEPCase", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1826737", "name": "C1826737#ent", "pos": [19, 20]}}
{"token": ["The", "N-terminal", "and", "C1310463#ent", "<e1>", "to", "harbor", "missense", "mutation", "clusters", "associated", "with", "AOA2", "and", "C4084756#ent", "<e2>", "."], "h": {"id": "C1310463", "name": "C1310463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4084756", "name": "C4084756#ent", "pos": [14, 15]}}
{"token": ["Vitamine", "K", "epoxide", "reductase", "complex", "subunit", "I", "VKORC1", ")", "is", "a", "key", "C0027203#ent", "<e1>", "in", "the", "vitamin", "K", "cycle", "cofactor", "required", "for", "the", "activation", "of", "C2002622#ent", "<e2>", "and", "is", "the", "target", "C0027203#ent", "<e1>", "of", "AVK", "inhibition", "."], "h": {"id": "C2002622", "name": "C2002622#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["15-Hydroxyprostaglandin", "dehydrogenase", "(", "PGDH", ")", ",", "localized", "primarily", "to", "chorion", "trophoblasts", ",", "is", "the", "key", "C0014442#ent", "<e1>", "responsible", "for", "the", "metabolism", "of", "C3540754#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [22, 23]}}
{"token": ["However", ",", "experimental", "data", "that", "the", "activities", "of", "the", "C3541394#ent", "<e1>", "involved", "in", "purine", "metabolism", "increased", "in", "C3811118#ent", "<e2>", "myocardium", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [17, 18]}}
{"token": ["VZV", "ORF47", "is", "a", "C0072402#ent", "<e1>", "recognized", "a", "consensus", "sequence", "to", "that", "of", "casein", "kinase", "II", "C0108555#ent", "<e2>", ")", "."], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0108555", "name": "C0108555#ent", "pos": [16, 17]}}
{"token": ["This", "result", "could", "be", "a", "good", "explanation", "to", "the", "observation", "that", "no", "clinical", "signs", "C0042880#ent", "<e1>", "observed", "in", "the", "warfarin-resistant", "strain", ",", "while", "a", "low", "C1428184#ent", "<e2>", "activity", "was", "found", "."], "h": {"id": "C0042880", "name": "C0042880#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1428184", "name": "C1428184#ent", "pos": [25, 26]}}
{"token": ["C1822783#ent", "<e1>", "may", "contribute", "to", "the", "pathogenesis", "of", "C0175166#ent", "<e2>", "scleroderma", ",", "vasculitic", "syndromes", "and", "systemic", "lupus", "erythematosus", "although", "the", "data", "available", "are", "limited", "."], "h": {"id": "C1822783", "name": "C1822783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0175166", "name": "C0175166#ent", "pos": [8, 9]}}
{"token": ["The", "recognition", "sequences", "the", "common", "C0011525#ent", "<e1>", "enzymes", "and", "their", "corresponding", "C0025831#ent", "<e2>", "are", "usually", "palindromes", "."], "h": {"id": "C0011525", "name": "C0011525#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025831", "name": "C0025831#ent", "pos": [11, 12]}}
{"token": ["Five", "diets", "previously", "developed", "for", "the", "green", "peach", "aphid", "and", "the", "C1572795#ent", "<e1>", "aphid", "were", "tested", "for", "their", "suitability", "for", "rearing", "C0947608#ent", "<e2>", "aphid", ",", "Aphis", "glycines", "."], "h": {"id": "C1572795", "name": "C1572795#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0947608", "name": "C0947608#ent", "pos": [21, 22]}}
{"token": ["C1136197#ent", "<e1>", "physically", "interacts", "with", "p53", "and", "p73", "in", "an", "C0068815#ent", "<e2>", "manner", "and", "protects", "them", "from", "20S", "proteasomal", "degradation"], "h": {"id": "C1136197", "name": "C1136197#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0068815", "name": "C0068815#ent", "pos": [10, 11]}}
{"token": ["The", "amino", "acid", "sequence", "rat", "C1429080#ent", "<e1>", "and", "its", "C1334043#ent", "<e2>", "nearly", "identical", "(", "98", "%", "similarity", ")", ",", "and", "both", "contain", "a", "conserved", "single", "membrane-spanning", "region", "in", "the", "middle", "of", "each", "sequence", "."], "h": {"id": "C1429080", "name": "C1429080#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["We", "examined", "the", "effects", "of", "inhibitor", "of", "5-lipoxygenase", ",", "C0081408#ent", "<e1>", ",", "in", "a", "group", "of", "eight", "C0004096#ent", "<e2>", "patients", "with", "known", "sensitivity", "to", "ASA", "accompanied", "by", "LTE4", "hyperexcretion", "."], "h": {"id": "C0081408", "name": "C0081408#ent", "pos": [9, 10]}, "relation": "may_prevent", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "CTLs", "lysed", "C0035869#ent", "<e1>", "target", "cells", "prior", "to", "production", "of", "C0042769#ent", "<e2>"], "h": {"id": "C0035869", "name": "C0035869#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [13, 14]}}
{"token": ["For", "comparison", ",", "the", "error-prone", "bypass", "DNA", "polymerases", "were", "C3889446#ent", "<e1>", "in", "the", "cells", "by", "irradiation", "with", "UV", "light", "C4225412#ent", "<e2>", "induction", ")", "prior", "to", "transformation", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4225412", "name": "C4225412#ent", "pos": [19, 20]}}
{"token": ["A", "retronphage", "'", "killer", "'", "gene", ",", "ORF336", ",", "when", "C3889446#ent", "<e1>", "from", "a", "plasmid", ",", "causes", "similar", "effects", "without", "C4225412#ent", "<e2>", "induction", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4225412", "name": "C4225412#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "the", "appropriate", "dose", "of", "C0093999#ent", "<e1>", "in", "combination", "with", "C1161438#ent", "<e2>", "for", "patients", "with", "gynecological", "malignancies"], "h": {"id": "C0093999", "name": "C0093999#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", ",", "the", "expression", "and", "distribution", "of", "the", "major", "gel-forming", "mucins", "C2983560#ent", "<e1>", "and", "MUC5B", "were", "studied", "in", "fatal", "status", "asthmaticus", "tissues", "bronchial", "biopsies", "C0282556#ent", "<e2>", "patients", "."], "h": {"id": "C2983560", "name": "C2983560#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [26, 27]}}
{"token": ["Although", "C1879974#ent", "<e1>", "is", "elevated", "more", "often", "in", "the", "presence", "of", "acute", "rejection", "its", "sensitivity", "does", "not", "allow", "C1879974#ent", "<e1>", "to", "replace", "the", "routine", "performance", "of", "C0014964#ent", "<e1>", "for", "monitoring", "rejection", "after", "heart", "transplantation"], "h": {"id": "C1879974", "name": "C1879974#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014964", "name": "C0014964#ent", "pos": [26, 27]}}
{"token": ["During", "a", "6-month", "period", ",", "C1879974#ent", "<e1>", "was", "measured", "in", "all", "patients", "referred", "for", "C0014964#ent", "<e2>", "as", "part", "of", "the", "routine", "follow-up", "after", "heart", "transplantation"], "h": {"id": "C1879974", "name": "C1879974#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014964", "name": "C0014964#ent", "pos": [14, 15]}}
{"token": ["C0035983#ent", "<e1>", "abolished", "and", "enflurane", "attenuated", "the", "potentiated-state", "contractions", ",", "whereas", "C0033487#ent", "<e2>", "had", "no", "apparent", "effect", "."], "h": {"id": "C0035983", "name": "C0035983#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [11, 12]}}
{"token": ["Primarily", "a", "pulmonary", "disease", "C0005716#ent", "<e1>", "is", "difficult", "to", "differentiate", "from", "other", "C0035243#ent", "<e2>", "clinical", "symptoms", "."], "h": {"id": "C0005716", "name": "C0005716#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [12, 13]}}
{"token": ["Translocation", "of", "Olig2", ",", "down-regulation", "of", "NG2", ",", "and", "increased", "C1415042#ent", "<e1>", "were", "recapitulated", "in", "vitro", "exposure", "of", "glial", "progenitors", "C1136365#ent", "<e2>", "bone", "morphogentic", "protein", "up-regulation", "of", "Notch-1", "."], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "the", "behavioral", "alterations", "shown", "by", "C0011848#ent", "<e1>", "rats", "are", "alleviated", "by", "C0268528#ent", "<e2>", "although", "high", "levels", "of", "plasma", "prolactin", "do", "not", "interfere", "with", "the", "mechanisms", "regulating", "water", "intake", "urine", "output"], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [15, 16]}}
{"token": ["An", "18-year-old", "woman", "presented", "with", "visual", "disturbance", "and", "endocrine", "dysfunction", "C0011848#ent", "<e1>", "delayed", "puberty", "hypothyroidism", ",", "hypoadrenalism", ",", "and", "C0268528#ent", "<e2>", ")", "."], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [19, 20]}}
{"token": ["C0011848#ent", "<e1>", "DI", ")", "was", "present", "in", "8.6", "%", "patients", "and", "C0268528#ent", "<e2>", "4.3", "%", "."], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [11, 12]}}
{"token": ["To", "explore", "the", "effects", "of", "C1414549#ent", "<e1>", "when", "it", "is", "C3889446#ent", "<e2>", ",", "on", "lymphoid", "cell", "and", "immune", "function", "in", "vivo", "transgenic", "mice", "generated", "."], "h": {"id": "C1414549", "name": "C1414549#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}}
{"token": ["The", "degree", "of", "hemolysis", "was", "decreased", "by", "treating", "intact", "cells", "with", "C0057911#ent", "<e1>", "(", "DIDS", ")", ",", "4,4'-dinitrostilbene-2,2'-disulfonate", "and", "pyridoxal", "5'-phosphate", "C1705623#ent", "<e2>", ")", "had", "little", "effect", "on", "the", "hemolysis", "."], "h": {"id": "C0057911", "name": "C0057911#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705623", "name": "C1705623#ent", "pos": [21, 22]}}
{"token": ["The", "calculated", "inhibitory", "effect", "of", "C1257966#ent", "<e1>", "on", "C1620185#ent", "<e2>", "highly", "correlated", "with", "the", "antimutagenicity", "of", "C1257966#ent", "<e1>", "in", "2-amino-3,4-dimethylimidazo[4,5-flquinoline", "(MelQ)-induced", "umu", "response", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1257966", "name": "C1257966#ent", "pos": [5, 6]}}
{"token": ["C0037199#ent", "<e1>", "is", "overdiagnosed", "as", "a", "cause", "of", "C0018681#ent", "<e2>", "because", "of", "the", "belief", "that", "pain", "over", "the", "sinuses", "must", "be", "related", "to", "the", "sinuses", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [8, 9]}}
{"token": ["The", "C0014442#ent", "<e1>", "was", "solubilized", "from", "chromatophores", "by", "using", "C0058629#ent", "<e2>", "the", "presence", "of", "glycerol", "and", "was", "purified", "by", "anion-exchange", "and", "gel", "filtration", "chromatography"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058629", "name": "C0058629#ent", "pos": [9, 10]}}
{"token": ["The", "C0014442#ent", "<e1>", "was", "solubilized", "with", "C0058629#ent", "<e2>", "purified", "to", "homogeneity", "by", "a", "combination", "of", "hydrophobic", "interaction", "and", "anion", "exchange", "chromatography"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058629", "name": "C0058629#ent", "pos": [6, 7]}}
{"token": ["The", "data", "obtained", "allow", "to", "conclude", "that", "the", "C0014442#ent", "<e1>", "solubilization", "by", "C0058629#ent", "<e2>", "a", "more", "native", "preparation", "in", "comparison", "with", "that", "obtained", "by", "solubilization", "in", "Tween", "80", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0058629", "name": "C0058629#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "C1705601#ent", "<e1>", "a", "lower", "responsiveness", "to", "the", "C0026249#ent", "<e2>", ",", "and", "B", "fraction", "cells", "not", "respond", "at", "all", "."], "h": {"id": "C1705601", "name": "C1705601#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "suggest", "that", "the", "Abeta", "deposition", "in", "senile", "plaques", "C0002395#ent", "<e1>", "brains", "might", "be", "a", "primary", "event", "activates", "C2827383#ent", "<e2>", "phosphorylates", "tau", "at", "S262", ",", "resulting", "in", "microtubule", "disruption", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [19, 20]}}
{"token": ["In", "this", "report", ",", "we", "describe", "targeted", "deletion", "at", "the", "C1415056#ent", "<e1>", "(", "alpha", "1,3-galactosyl", "transferase", "and", "PrP", "(", "C0033164#ent", "<e2>", "loci", "in", "primary", "fibroblasts", "livestock", "."], "h": {"id": "C1415056", "name": "C1415056#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033164", "name": "C0033164#ent", "pos": [19, 20]}}
{"token": ["Immunoblotting", "of", "the", "peroxisomal", "beta-oxidation", "C3541394#ent", "<e1>", "gave", "normal", "results", "suggesting", "retained", "immunoreactivity", "but", "catalytic", "inactivity", "one", "of", "the", "C3541394#ent", "<e1>", "involved", ",", "probably", "either", "the", "C1413078#ent", "<e1>", "the", "peroxisomal", "ketothiolase", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413078", "name": "C1413078#ent", "pos": [26, 27]}}
{"token": ["Furthermore", ",", "orotate", "phosphoribosyltransferase", "orotidylate", "decarboxylase", "this", "parasite", "were", "resolved", "from", "each", "other", "by", "biospecific", "elution", "from", "blue", "Sepharose", "indicating", "that", "the", "parasite", "C3541394#ent", "<e1>", "do", "not", "exist", "as", "a", "C1413078#ent", "<e2>"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1413078", "name": "C1413078#ent", "pos": [30, 31]}}
{"token": ["A", "missense", "mutation", "the", "C3811246#ent", "<e1>", "TPM3", ")", "has", "been", "associated", "with", "C3273659#ent", "<e2>", "in", "one", "family", "."], "h": {"id": "C3811246", "name": "C3811246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273659", "name": "C3273659#ent", "pos": [12, 13]}}
{"token": ["When", "C2936886#ent", "<e1>", "was", "present", ",", "there", "was", "a", "significant", "increase", "in", "C1174250#ent", "<e2>", "activity", "in", "the", "supernatants", "by", "1", "hour", "of", "incubation", "and", "a", "slight", "decline", "at", "later", "time", "points"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1174250", "name": "C1174250#ent", "pos": [12, 13]}}
{"token": ["C0700480#ent", "<e1>", "as", "an", "initial", "treatment", "for", "C0042109#ent", "<e2>", "effective", "and", "safe", "."], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [7, 8]}}
{"token": ["C1421293#ent", "<e1>", "AS", ")", "is", "a", "neurodevelopmental", "disorder", "characterized", "by", "mental", "retardation", "speech", "impairment", "C0004134#ent", "<e2>", ",", "and", "happy", "disposition", "frequent", "smiling", "."], "h": {"id": "C1421293", "name": "C1421293#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [14, 15]}}
{"token": ["The", "inheritance", "of", "C1421293#ent", "<e1>", "a", "disorder", "characterised", "by", "mental", "retardation", "epilepsy", ",", "C0004134#ent", "<e2>", ",", "and", "a", "happy", "disposition", "is", "debated", "because", "affected", "sibs", "occur", "less", "frequently", "than", "expected", "with", "autosomal", "recessive", "inheritance", "."], "h": {"id": "C1421293", "name": "C1421293#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [13, 14]}}
{"token": ["To", "this", "date", ",", "no", "report", "given", "a", "detailed", "discussion", "of", "the", "type", "of", "C0036572#ent", "<e1>", "and", "ictal", "EEG", "in", "C0023522#ent", "<e2>"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0023522", "name": "C0023522#ent", "pos": [20, 21]}}
{"token": ["C0376515#ent", "<e1>", ",", "on", "the", "other", "hand", ",", "effectively", "inhibited", "C3536807#ent", "<e2>", "D-induced", "DNA", "fragmentation", "the", "appearance", "of", "PS", "at", "the", "cells", "outer", "leaflet", "and", "the", "decrease", "in", "deltapsi[m", "]", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536807", "name": "C3536807#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "stable", "expression", "of", "the", "mammalian", "death", "suppressor", "C0376515#ent", "<e1>", "failed", "to", "block", "C3536807#ent", "<e2>", "D-", "or", "AcMNPV-induced", "apoptosis", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536807", "name": "C3536807#ent", "pos": [15, 16]}}
{"token": ["However", ",", "since", "one", "goal", "of", "treatment", "of", "C0242172#ent", "<e1>", "be", "to", "eliminate", "organisms", "from", "the", "upper", "genital", "tract", "C0008809#ent", "<e2>", "may", "not", "provide", "optimal", "single-agent", "therapy", "for", "C0242172#ent", "<e1>"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0242172", "name": "C0242172#ent", "pos": [8, 9]}}
{"token": ["Because", "FGF-2", "controls", "a", "number", "of", "proteolytic", "activities", "various", "cell", "types", "we", "tested", "its", "effect", "on", "vascular", "endothelial", "cell", "expression", "of", "MMP-3", "(", "C1723257#ent", "<e1>", ")", ",", "a", "broad-spectrum", "proteinase", "implicated", "in", "C0010054#ent", "<e2>"], "h": {"id": "C1723257", "name": "C1723257#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [32, 33]}}
{"token": ["We", "investigated", "the", "association", "of", "matrix", "metalloproteinase-3", "C1723257#ent", "<e1>", ")", "and", "paraoxonase", "1", "PON1", ")", "55/192", "polymorphisms", "with", "C0010054#ent", "<e2>", "CAD", ")", "and", "the", "number", "of", "diseased", "vessels", "in", "patients", "with", "CAD", "."], "h": {"id": "C1723257", "name": "C1723257#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [18, 19]}}
{"token": ["We", "now", "expand", "the", "investigation", "to", "demonstrate", "that", "C2607887#ent", "<e1>", "is", "a", "substrate", "for", "Pgp", "and", "C0919458#ent", "<e2>", "MRP1", ")", "."], "h": {"id": "C2607887", "name": "C2607887#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0919458", "name": "C0919458#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "the", "safety", "and", "therapeutic", "response", "a", "regimen", "consisting", "of", "cyclophosphamide/doxorubicin/vincristine/prednisone", "(", "C2985165#ent", "<e1>", ")", "plus", "rituximab", "in", "patients", "with", "Sj\u00f6gren's", "syndrome", "C0085077#ent", "<e2>", ")", "and", "aggressive", "non-Hodgkin's", "lymphoma", "NHL", ")", "."], "h": {"id": "C2985165", "name": "C2985165#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085077", "name": "C0085077#ent", "pos": [23, 24]}}
{"token": ["The", "genes", "of", "Streptomyces", "coelicolor", "A3(2", "encoding", "catalytic", "subunits", "ClpP", ")", "and", "regulatory", "subunits", "(", "C1413508#ent", "<e1>", "and", "ClpC", ")", "of", "the", "ATP-dependent", "protease", "C1425434#ent", "<e2>", "were", "cloned", ",", "mapped", "and", "characterized", "."], "h": {"id": "C1413508", "name": "C1413508#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1425434", "name": "C1425434#ent", "pos": [24, 25]}}
{"token": ["Among", "the", "unspecified", "medicinal", "drug", "poisonings", "were", "five", "cases", "with", "very", "high", "blood", "levels", "C0009214#ent", "<e1>", ",", "indicating", "that", "this", "C1254351#ent", "<e2>", "played", "an", "important", "contribution", "to", "the", "cause", "of", "death", "."], "h": {"id": "C0009214", "name": "C0009214#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [20, 21]}}
{"token": ["Hypertonia", ",", "which", "results", "from", "motor", "pathway", "defects", "in", "the", "central", "nervous", "system", "CNS", ")", ",", "is", "observed", "in", "numerous", "neurological", "conditions", "including", "C0007789#ent", "<e1>", "stroke", ",", "spinal", "cord", "injury", "stiff-person", "syndrome", "spastic", "paraplegia", "dystonia", "and", "C1868675#ent", "<e2>"], "h": {"id": "C0007789", "name": "C0007789#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1868675", "name": "C1868675#ent", "pos": [36, 37]}}
{"token": ["This", "C0039082#ent", "<e1>", "usually", "occurs", "in", "patients", "with", "sickle", "cell", "disease", "possibly", "C0005283#ent", "<e2>", "who", "receive", "multiple", "transfusions"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [12, 13]}}
{"token": ["In", "mild", "beta", "thalassemia", "levels", "are", "much", "higher", "than", "in", "severe", "beta", "thalassemia", "yet", "black", "patients", "with", "the", "C0039082#ent", "<e1>", "as", "deficient", "in", "beta", "chain", "synthesis", "severe", "C0005283#ent", "<e2>", "patients", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [27, 28]}}
{"token": ["Spinal", "cord", "compression", "a", "consequence", "of", "mass", "lesions", "to", "extramedullary", "hematopoiesis", "a", "well-described", "but", "rare", "C0039082#ent", "<e1>", "occurring", "in", "C0005283#ent", "<e2>", "and", "some", "other", "hematologic", "conditions"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [19, 20]}}
{"token": ["Northern", "and", "microarray", "analyses", "performed", "to", "assess", "the", "effect", "of", "loss", "of", "the", "C0808900#ent", "<e1>", "COOH", "terminus", "on", "transcriptional", "modulation", "C0908880#ent", "<e2>", "target", "genes", "."], "h": {"id": "C0808900", "name": "C0808900#ent", "pos": [13, 14]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0908880", "name": "C0908880#ent", "pos": [20, 21]}}
{"token": ["To", "search", "for", "C0086376#ent", "<e1>", "whose", "interaction", "with", "C1336616#ent", "<e2>", "disturbed", "by", "mutations", "in", "patients", "we", "used", "the", "yeast", "two-hybrid", "system", "report", "the", "isolation", "of", "a", "novel", "XPB", "interacting", "protein", ",", "SUG1", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336616", "name": "C1336616#ent", "pos": [8, 9]}}
{"token": ["To", "explore", "the", "somatic", "mutations", "of", "C3272445#ent", "<e1>", "Chinese", "patients", "with", "C0024790#ent", "<e2>", "PNH", ")", "and", "to", "compare", "these", "mutations", "with", "those", "in", "non-Chinese", "PNH", "patients", "."], "h": {"id": "C3272445", "name": "C3272445#ent", "pos": [6, 7]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0024790", "name": "C0024790#ent", "pos": [11, 12]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "elucidate", "whether", "C3272445#ent", "<e1>", "is", "the", "gene", "responsible", "for", "all", "cases", "of", "C0024790#ent", "<e2>", "and", "to", "characterize", "further", "the", "somatically", "acquired", "abnormalities", "of", "this", "gene", "."], "h": {"id": "C3272445", "name": "C3272445#ent", "pos": [8, 9]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0024790", "name": "C0024790#ent", "pos": [18, 19]}}
{"token": ["C0014025#ent", "<e1>", "does", "not", "produce", "hypokalaemia", ",", "hyperglycaemia", ",", "C0740394#ent", "<e2>", "or", "hypercholesterolaemia", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0740394", "name": "C0740394#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "identify", "a", "new", "C1334033#ent", "<e1>", "target", ":", "the", "C0079429#ent", "<e2>", "encoding", "the", "cell", "cycle-regulatory", "protein", "cyclin", "D3"], "h": {"id": "C1334033", "name": "C1334033#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}}
{"token": ["Brain", "tissue", "at", "necropsy", "from", "five", "cases", "of", "C0013080#ent", "<e1>", "six", "controls", "was", "analysed", "for", "changes", "in", "C0243051#ent", "<e2>", "markers", "."], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [17, 18]}}
{"token": ["To", "try", "to", "elucidate", "this", "syndrome", "the", "endocrine", "pattern", "by", "serum", "estrogen", "Fig.", "1", ")", "and", "C2757070#ent", "<e1>", "(", "Fig.", "2", ")", "levels", "was", "followed", "in", "12", "C0030612#ent", "<e2>", "cows", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030612", "name": "C0030612#ent", "pos": [27, 28]}}
{"token": ["des-AA1", ",", "2", ",", "4", ",", "5", ",", "12", ",", "13-[D-Trp]SRIF", "prevented", "the", "C0020456#ent", "<e1>", "induced", "by", "surgical", "stress", "by", "ic", "administration", "of", "C1337111#ent", "<e2>", "or", "carbacol", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [23, 24]}}
{"token": ["A", "follow-up", "of", "nine", "of", "the", "C0020456#ent", "<e1>", "cases", "showed", "a", "significant", "decline", "in", "C1337111#ent", "<e2>", "and", "insulin", "levels", "with", "recovery", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [14, 15]}}
{"token": ["Four", "cases", "are", "reported", ":", "a", "patient", "with", "C0036421#ent", "<e1>", "one", "with", "C0032453#ent", "<e2>", "one", "with", "Gougerot-Sj\u00f6gren's", "disease", "one", "with", "atypical", "and", "frustes", "connective", "tissue", "lesions", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032453", "name": "C0032453#ent", "pos": [12, 13]}}
{"token": ["Mutations", "of", "the", "C1418270#ent", "<e1>", "the", "most", "frequent", "cause", "of", "C0030567#ent", "<e2>"], "h": {"id": "C1418270", "name": "C1418270#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [10, 11]}}
{"token": ["These", "results", "indicate", "that", "C0215825#ent", "<e1>", "plays", "important", "roles", "in", "cardiovascular", "and", "C0022658#ent", "<e2>", "suppression", "of", "oxidative", "stress", "production", "through", "activation", "of", "second", "messengers", "cAMP", "and", "nitric", "oxide\u00adcGMP-dependent", "signaling", "pathways"], "h": {"id": "C0215825", "name": "C0215825#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [12, 13]}}
{"token": ["After", "heat", "shock", "HSP25", ",", "alpha", "B-crystallin", "C1415760#ent", "<e1>", "were", "up-regulated", ",", "while", "after", "oxidative", "stress", "specific", "induction", "of", "C1415619#ent", "<e2>", "and", "alpha", "B-crystallin", "observed", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [19, 20]}}
{"token": ["We", "demonstrate", "that", "heat-shock", "induced", "expression", "of", "heat-shock", "protein", "70", "C1415760#ent", "<e1>", ")", "(", "rat", "and", "human", ")", "and", "C1415619#ent", "<e2>", "(", "human", ")", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [19, 20]}}
{"token": ["Sleep", "recordings", "useful", "for", "localizing", "a", "focus", "in", "C0036572#ent", "<e1>", "for", "differentiation", "of", "C0014544#ent", "<e2>", "non-epileptic", "seizure-like", "sleep", "disturbances", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}}
{"token": ["Arachidonic", "acid", "C0025517#ent", "<e1>", "through", "the", "lipoxygenase", "pathways", "hydroperoxy", "acids", "HPETEs", ")", ",", "C0772110#ent", "<e2>", "HETEs", ")", ",", "and", "leukotrienes", ",", "derivatives", "of", "5-HPETE", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0772110", "name": "C0772110#ent", "pos": [13, 14]}}
{"token": ["By", "monitoring", "in", "vivo", "activation", "of", "luciferase", "reporter", "gene", "by", "C1367469#ent", "<e1>", "promoter", ",", "we", "observed", "activation", "of", "C3273648#ent", "<e2>", "a", "specific", "stage", "of", "the", "hair", "cycle"], "h": {"id": "C1367469", "name": "C1367469#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273648", "name": "C3273648#ent", "pos": [18, 19]}}
{"token": ["Our", "data", "indicate", "that", "C1413132#ent", "<e1>", "mRNA", "is", "constitutively", "expressed", "in", "rabbit", "C1539322#ent", "<e2>", "and", "activation", "of", "CPP32", "protein", "a", "pivotal", "role", "in", "SNP-induced", "C1539322#ent", "<e2>", "apoptosis", "."], "h": {"id": "C1413132", "name": "C1413132#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [12, 13]}}
{"token": ["Our", "results", "showed", "a", "dose-dependent", "increase", "of", "C1413132#ent", "<e1>", "activity", "in", "C1539322#ent", "<e2>", ",", "with", "a", "maximal", "10-fold", "increase", "after", "SNP", "treatment", "."], "h": {"id": "C1413132", "name": "C1413132#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [11, 12]}}
{"token": ["C0074062#ent", "<e1>", "composed", "of", "A", ",", "B", ",", "C", ",", "and", "C0599220#ent", "<e2>"], "h": {"id": "C0074062", "name": "C0074062#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [11, 12]}}
{"token": ["C3665349#ent", "<e1>", "significantly", "decreased", "the", "extracellular", "C1705556#ent", "<e2>", "and", "ADP", "hydrolysis", "and", "this", "effect", "was", "significantly", "reversed", "when", "cell", "cultures", "supplemented", "with", "1", "microM", "T3", "or", "0.1", "microM", "T4", "for", "30", "min", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [6, 7]}}
{"token": ["Emphasis", "is", "put", "on", "the", "termination", "and", "modulation", "of", "the", "JAK/STAT", "signalling", "pathway", "by", "tyrosine", "phosphatases", "the", "C1332762#ent", "<e1>", "(", "suppressor", "of", "cytokine", "signalling", "feedback", "inhibitors", "and", "C1413968#ent", "<e2>", "(", "protein", "inhibitor", "activated", "STAT", ")", "proteins", "."], "h": {"id": "C1332762", "name": "C1332762#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413968", "name": "C1413968#ent", "pos": [27, 28]}}
{"token": ["The", "C0310298#ent", "<e1>", "was", "to", "categorize", "C0235527#ent", "<e2>", "digits", "as", "odd", "or", "even", "."], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0235527", "name": "C0235527#ent", "pos": [6, 7]}}
{"token": ["Twelve", "patients", "including", "6", "ischemic", "heart", "diseases", "5", "C0018824#ent", "<e1>", "and", "one", "adult", "atrial", "septal", "defect", "with", "mitral", "and", "C0040961#ent", "<e2>", "treated", "with", "circulatory", "assist", "system", "postoperative", "severe", "low-cardiac", "output", "syndrome"], "h": {"id": "C0018824", "name": "C0018824#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [19, 20]}}
{"token": ["Clinical", "features", "included", "C0018824#ent", "<e1>", "triple", "valvular", "lesion", ":", "C0040961#ent", "<e2>", "stenosis", ",", "pulmonary", "artery", "stenosis", "mitral", "insufficiency"], "h": {"id": "C0018824", "name": "C0018824#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [9, 10]}}
{"token": ["In", "this", "proposal", ",", "we", "investigated", "if", "the", "inhibition", "of", "T", "cell", "activation", "with", "the", "C1619966#ent", "<e1>", "abrogate", "the", "C0027721#ent", "<e2>", "administered", "systemically", "."], "h": {"id": "C1619966", "name": "C1619966#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [19, 20]}}
{"token": ["Bacterial", "causes", "are", "categorized", "by", "clinical", "presentation", "anatomic", "location", ",", "and", "causative", "organisms", "the", "categories", "of", "pyomyositis", ",", "C0085222#ent", "<e1>", "Staphylococcus", "aureus", "myositis", "group", "A", "streptococcal", "necrotizing", "myositis", "group", "B", "streptococcal", "myositis", "clostridial", "gas", "gangrene", "and", "C0017105#ent", "<e2>"], "h": {"id": "C0085222", "name": "C0085222#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017105", "name": "C0017105#ent", "pos": [36, 37]}}
{"token": ["Further", "evidence", "was", "the", "coincident", "isoelectric", "points", "the", "predominant", "isoamylase", "in", "the", "sera", "of", "the", "C0023895#ent", "<e1>", "patients", "and", "of", "patients", "with", "C0029400#ent", "<e2>"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029400", "name": "C0029400#ent", "pos": [22, 23]}}
{"token": ["In", "support", "of", "this", "hypothesis", ",", "a", "recent", "clinical", "study", "in", "patients", "with", "C1956346#ent", "<e1>", "that", "treatment", "with", "the", "lipophilic", "dihydropyridine-type", "calcium", "antagonist", "C0051696#ent", "<e2>", "resulted", "in", "significantly", "fewer", "cardiovascular", "procedures", "events", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [23, 24]}}
{"token": ["To", "estimate", "the", "potential", "savings", "in", "overall", "cardiovascular", "disease", "CVD", ")", "treatment", "costs", "the", "US", "population", "with", "C1956346#ent", "<e1>", "CAD", ")", "resulting", "from", "the", "use", "of", "C0051696#ent", "<e2>", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [26, 27]}}
{"token": ["C0795910#ent", "<e1>", "caused", "by", "mutations", "in", "the", "C0079429#ent", "<e2>", "for", "the", "gap", "junction", "protein", "connexin32", "."], "h": {"id": "C0795910", "name": "C0795910#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}}
{"token": ["During", "the", "haploid", "stage", "spermatogenesis", ",", "histones", "are", "gradually", "replaced", ",", "firstly", "by", "C1420830#ent", "<e1>", "later", "by", "C1823091#ent", "<e2>"], "h": {"id": "C1420830", "name": "C1420830#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1823091", "name": "C1823091#ent", "pos": [17, 18]}}
{"token": ["Among", "those", "identified", "was", "C1416968#ent", "<e1>", ",", "a", "small", "Maf", "family", "basic", "region", "and", "leucine", "zipper", "transcriptional", "repressor", "C1422492#ent", "<e2>", "expressed", "in", "immature", "neurons", "."], "h": {"id": "C1416968", "name": "C1416968#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [18, 19]}}
{"token": ["In", "the", "diagnosis", "of", "esophageal", "foreign", "bodies", "children", ",", "C0038450#ent", "<e1>", "and", "dyspnea", "as", "well", "as", "C0011168#ent", "<e2>", "are", "important", "."], "h": {"id": "C0038450", "name": "C0038450#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [16, 17]}}
{"token": ["HIV-1", "Tat", "interacts", "with", "the", "human", "transcriptional", "coactivator", "C0256079#ent", "<e1>", "C1538565#ent", "<e2>", ")", "via", "the", "KIX", "domain", "C1538565#ent", "<e2>", "."], "h": {"id": "C0256079", "name": "C0256079#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538565", "name": "C1538565#ent", "pos": [10, 11]}}
{"token": ["RSTS", "is", "caused", "by", "chromosomal", "rearrangements", "point", "mutations", "in", "one", "copy", "of", "the", "C0256079#ent", "<e1>", "CREBBP", "or", "C1538565#ent", "<e2>", ")", "in", "16p13.3", "."], "h": {"id": "C0256079", "name": "C0256079#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1538565", "name": "C1538565#ent", "pos": [17, 18]}}
{"token": ["The", "point", "mutation", "Tyr658Ala", "in", "the", "C0256079#ent", "<e1>", "CBD", ")", "was", "shown", "to", "abolish", "the", "binding", "activity", "C1538565#ent", "<e2>", "to", "phospho-CREB", ",", "the", "activated", "form", "of", "CREB", "."], "h": {"id": "C0256079", "name": "C0256079#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538565", "name": "C1538565#ent", "pos": [17, 18]}}
{"token": ["A", "tyrosine-phosphorylated", "octapeptide", "derived", "from", "mouse", "Spry2", "inhibits", "C1333707#ent", "<e1>", "from", "binding", "FRS2", ",", "C1706044#ent", "<e2>", "or", "mouse", "Spry2", "in", "vitro", "blocks", "activation", "of", "the", "extracellular-signal-regulated", "kinase", "ERK", ")", "in", "cells", "stimulated", "by", "growth", "factor"], "h": {"id": "C1333707", "name": "C1333707#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [14, 15]}}
{"token": ["Further", "definition", "of", "the", "role", "in", "prevention", "and", "treatment", "of", "C0030920#ent", "<e1>", "selective", "vasodilators", "immunomodulators", "and", "mitotic", "agents", "the", "C1367721#ent", "<e2>", "to", "be", "carried", "out", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", "to", "normal", "epidermis", ",", "lesional", "psoriatic", "epidermis", "primarily", "C1367601#ent", "<e1>", "tPA", ")", "activity", "and", "much", "lower", "levels", "of", "urokinase", "type", "plasminogen", "activator", "C1706177#ent", "<e2>", ")", "activity", "."], "h": {"id": "C1367601", "name": "C1367601#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706177", "name": "C1706177#ent", "pos": [24, 25]}}
{"token": ["The", "reactions", "and", "partial", "syntheses", "of", "estrogens", ",", "C0002842#ent", "<e1>", ",", "pregnanes", ",", "cholic", "acid", "derivatives", "cholestanes", "and", "C3537249#ent", "<e2>", "analogues", "are", "covered", "."], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3537249", "name": "C3537249#ent", "pos": [18, 19]}}
{"token": ["To", "identify", "the", "disease-causing", "mutation", "in", "a", "large", "group", "of", "C0007758#ent", "<e1>", "patients", ",", "we", "searched", "for", "mutations", "in", "the", "C3811241#ent", "<e2>"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3811241", "name": "C3811241#ent", "pos": [20, 21]}}
{"token": ["Partial", "characterization", "revealed", "that", "NCA", "was", "partly", "heat", "labile", ",", "C0960371#ent", "<e1>", "sensitive", ",", "and", "predominantly", "C0059747#ent", "<e2>", "extractable", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0059747", "name": "C0059747#ent", "pos": [16, 17]}}
{"token": ["C2827469#ent", "<e1>", "however", ",", "is", "a", "consequence", "of", "C0020456#ent", "<e2>", "."], "h": {"id": "C2827469", "name": "C2827469#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [8, 9]}}
{"token": ["Loss", "of", "hypomethylation", "at", "high", "copy", "number", "indicate", "that", "saturable", "C0812382#ent", "<e1>", "protect", "the", "C1415615#ent", "<e2>", "promoter", "from", "methylation", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415615", "name": "C1415615#ent", "pos": [14, 15]}}
{"token": ["C0057252#ent", "<e1>", "is", "highly", "expressed", "in", "sclera", "and", "sternum", ",", "whereas", "C0126273#ent", "<e2>", "is", "expressed", "in", "these", "tissues", ",", "as", "well", "as", "in", "liver", ",", "at", "very", "low", "levels", "."], "h": {"id": "C0057252", "name": "C0057252#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0126273", "name": "C0126273#ent", "pos": [11, 12]}}
{"token": ["Small", "leucine-rich", "proteoglycans", "SLRPs", ")", "C0057252#ent", "<e1>", ",", "biglycan", ",", "fibromodulin", "and", "C0126273#ent", "<e2>", "are", "secreted", "extracellular", "matrix", "molecules", "associate", "with", "fibrillar", "collagens", "regulate", "collagen", "fibrillogenesis"], "h": {"id": "C0057252", "name": "C0057252#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0126273", "name": "C0126273#ent", "pos": [12, 13]}}
{"token": ["During", "adulthood", "C1415467#ent", "<e1>", "maintains", "normal", "brain", "function", "recent", "evidence", "suggests", "that", "reduced", "C1415467#ent", "<e1>", "intake", "in", "adults", "is", "linked", "with", "a", "number", "of", "C0042075#ent", "<e1>", "schizophrenia", "and", "depression", "."], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [24, 25]}}
{"token": ["However", ",", "the", "binding", "strength", "of", "the", "complex", "including", "caldesmon", "and", "MBS-G-actin", "cleaved", "at", "the", "subdomain-2", "loop", "with", "C0038597#ent", "<e1>", "decreased", "fivefold", "(", "C1705240#ent", "<e2>", "approximately", "0.20", "microM", ")", "."], "h": {"id": "C0038597", "name": "C0038597#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [23, 24]}}
{"token": ["We", "hypothesized", "that", "lower", "protein", "C", "higher", "type", "1", "plasminogen", "activator", "inhibitor", "C1705527#ent", "<e1>", ")", "levels", "in", "plasma", "would", "be", "associated", "with", "primary", "graft", "dysfunction", "C3274756#ent", "<e2>", ")", "after", "lung", "transplantation"], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3274756", "name": "C3274756#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "C1419279#ent", "<e1>", "senses", "the", "frequency", "of", "complex", "C1413043#ent", "<e2>", "+", "signals", ",", "decoding", "them", "through", "a", "regulation", "of", "the", "activation", "state", "Ras", "."], "h": {"id": "C1419279", "name": "C1419279#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [9, 10]}}
{"token": ["Recently", ",", "we", "identified", "CAPRI", "and", "C1419279#ent", "<e1>", "as", "related", "C1413043#ent", "<e2>", "+", "-triggered", "Ras", "GTPase-activating", "proteins"], "h": {"id": "C1419279", "name": "C1419279#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [10, 11]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "examine", "the", "effects", "of", "C0006168#ent", "<e1>", "on", "changes", "in", "vulnerability", "to", "ventricular", "fibrillation", "C0042510#ent", "<e2>", ")", "and", "refractoriness", "which", "occur", "during", "acute", "myocardial", "infarction"], "h": {"id": "C0006168", "name": "C0006168#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [20, 21]}}
{"token": ["Preliminary", "data", "presented", "from", "an", "ongoing", "comparative", "study", "prehospital", "use", "of", "C0006168#ent", "<e1>", "lidocaine", "for", "C0042510#ent", "<e2>", "."], "h": {"id": "C0006168", "name": "C0006168#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [15, 16]}}
{"token": ["The", "purified", "C0014442#ent", "<e1>", "was", "inhibited", "by", "C0919442#ent", "<e2>", ",", "SH-reagent", ",", "quercetin", ",", "hexesterol", ",", "stilbestrol", ",", "disulfiram", "and", "divalent", "cation", "as", "Cu2+", "Hg2+", "Cd2+"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919442", "name": "C0919442#ent", "pos": [7, 8]}}
{"token": ["We", "also", "found", "that", "Mdy2", "interacted", "with", "the", "N-terminal", "region", "of", "C3538854#ent", "<e1>", "and", "that", "Mdy2", "appeared", "to", "interact", "physically", "with", "C1424222#ent", "<e2>", "."], "h": {"id": "C3538854", "name": "C3538854#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1424222", "name": "C1424222#ent", "pos": [21, 22]}}
{"token": ["Synthetic", "lethality", "SGT2", "and", "YDJ1", "was", "observed", "after", "the", "cells", "were", "under", "stress", ",", "although", "C3538854#ent", "<e1>", "might", "not", "interact", "physically", "with", "C1424222#ent", "<e2>", "."], "h": {"id": "C3538854", "name": "C3538854#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1424222", "name": "C1424222#ent", "pos": [22, 23]}}
{"token": ["The", "presence", "of", "C1867743#ent", "<e1>", "the", "absence", "of", "other", "risk", "factors", "this", "new", "case", "of", "C0342895#ent", "<e2>", "questions", "regarding", "the", "risk", "of", "atherosclerosis", ",", "which", "has", "previously", "been", "reported", "to", "be", "nonexistent", "."], "h": {"id": "C1867743", "name": "C1867743#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [15, 16]}}
{"token": ["The", "authors", "report", "two", "patients", "with", "C0030360#ent", "<e1>", "from", "unrelated", "SOD1-negative", "familial", "C1704945#ent", "<e2>", "families", "."], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [12, 13]}}
{"token": ["Three", "men", "were", "initially", "diagnosed", "as", "having", "primary", "lateral", "sclerosis", "C0030360#ent", "<e1>", ")", ",", "but", "eventually", "developed", "amyotrophic", "lateral", "sclerosis", "C1704945#ent", "<e2>", ")", "after", "7.5", ",", "9", ",", "and", "at", "least", "27", "years", "."], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [20, 21]}}
{"token": ["In", "this", "study", ",", "we", "compared", "the", "effects", "of", "C0001644#ent", "<e1>", "clenbuterol", "and", "of", "a", "novel", "beta3-adrenoceptor", "agonist", "C0769061#ent", "<e2>", ",", "on", "urinary", "bladder", "external", "urethral", "sphincter", "function", "rat", ",", "rabbit", "and", "human", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0769061", "name": "C0769061#ent", "pos": [18, 19]}}
{"token": ["C0245514#ent", "<e1>", "is", "an", "C0243192#ent", "<e2>", "of", "the", "peroxisome", "proliferator-activated", "receptor-gamma", "PPAR-gamma", ")", ",", "which", "has", "been", "shown", "to", "improve", "the", "metabolic", "control", "type", "2", "diabetes"], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}}
{"token": ["Thiazolidinediones", ",", "also", "called", "C0245514#ent", "<e1>", ",", "are", "insulin", "sensitisers", "act", "as", "C0243192#ent", "<e2>", "of", "the", "peroxisome", "proliferator-activated", "receptors-gamma", "PPARgamma", ")", "."], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}}
{"token": ["C0245514#ent", "<e1>", ",", "the", "new", "oral", "antidiabetic", "drugs", "C0243192#ent", "<e2>", "of", "peroxisome", "proliferator-activated", "receptor", "have", "been", "shown", "to", "improve", "peripheral", "insulin", "sensitivity", "and", "to", "also", "delay", "atherosclerosis", "progression", "in", "experimental", "models"], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [8, 9]}}
{"token": ["DFP", "treatment", "also", "increases", "in", "vitro", "autophosphorylation", "of", "Ca2", "+", "calmodulin-dependent", "protein", "kinase", "II", "C0054521#ent", "<e1>", "and", "the", "phosphorylation", "of", "several", "C1414120#ent", "<e2>", "the", "hen", "brain", "."], "h": {"id": "C0054521", "name": "C0054521#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [21, 22]}}
{"token": ["The", "C0017718#ent", "<e1>", "treatment", "produced", "alternating", "periods", "of", "C0020456#ent", "<e2>", "and", "normoglycemia", "in", "the", "pregnant", "hamsters", "enlarged", "placentae", "and", "fetuses", "with", "small", "urinary", "bladders", "microphthalmia", "and", "skeletal", "abnormalities", "the", "sternum", ",", "caudal", "vertebrae", "pelvic", "bones", "and", "femora", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [8, 9]}}
{"token": ["C0017718#ent", "<e1>", "had", "no", "effects", "on", "arginine-induced", "insulin", "secretion", "at", "euglycaemia", "and", "C0020456#ent", "<e2>", ",", "but", "significantly", "(", "40", "-", "50", "%", ")", "impaired", "glucose-induced", "insulin", "secretion", "both", "first", "and", "second", "phases", ")", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [12, 13]}}
{"token": ["This", "analysis", "revealed", "that", "C0017337#ent", "<e1>", "in", "the", "20q13", "chromosomal", "region", "C1413749#ent", "<e2>", ",", "ZNF217", ",", "MYBL2", ",", "and", "STK15", ",", "were", "significantly", "overexpressed", "in", "this", "tumor", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413749", "name": "C1413749#ent", "pos": [11, 12]}}
{"token": ["IL-2-induced", "MAP", "kinase", "activation", "was", "only", "slightly", "inhibited", "by", "PP1", ",", "suggesting", "that", "C0919477#ent", "<e1>", "is", "not", "essential", "for", "IL-2-induced", "C0170168#ent", "<e2>", "activation", "in", "human", "T", "cells"], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [20, 21]}}
{"token": ["The", "growth", "of", "cells", "that", "expressed", "dominant", "negative", "C0919477#ent", "<e1>", "was", "unaffected", ",", "however", ",", "despite", "the", "inhibition", "of", "C0170168#ent", "<e2>"], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [19, 20]}}
{"token": ["Spathodea", "campanulata", "stem", "bark", "decoction", "(", "C1419846#ent", "<e1>", ")", "has", "shown", "C0020616#ent", "<e2>", "mice", "."], "h": {"id": "C1419846", "name": "C1419846#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [11, 12]}}
{"token": ["Juvenile", "visceral", "steatosis", "(", "jvs", ")", "mice", ",", "isolated", "from", "the", "C3H-H-2", "degrees", "strain", ",", "exibit", "a", "systemic", "carnitine", "deficiency", "C1419846#ent", "<e1>", ")", "phenotype", "and", "develop", "fatty", "liver", "hyperammonemia", "and", "C0020616#ent", "<e2>", "."], "h": {"id": "C1419846", "name": "C1419846#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [30, 31]}}
{"token": ["C0070592#ent", "<e1>", "is", "a", "succinimide", "antiepileptic", "drug", "in", "the", "treatment", "of", "C0014553#ent", "<e2>"], "h": {"id": "C0070592", "name": "C0070592#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C0812253#ent", "<e1>", "is", "a", "novel", "molecular", "adapter", "WASP", "and", "C1335892#ent", "<e2>", "and", "may", "potentially", "transfer", "these", "molecules", "to", "the", "cytoskeleton", "through", "association", "with", "cytoskeletal", "proteins", "as", "Hic-5", "."], "h": {"id": "C0812253", "name": "C0812253#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [11, 12]}}
{"token": ["Transmembrane", "resistance", "was", "also", "used", "a", "measure", "of", "the", "ability", "of", "C1516312#ent", "<e1>", "prevent", "TNF-alpha/butyrate-mediated", "damage", "to", "epithelial", "C0872351#ent", "<e2>", "."], "h": {"id": "C1516312", "name": "C1516312#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [18, 19]}}
{"token": ["The", "concept", "that", "the", "host", "response", "to", "a", "single", "agent", "evoke", "two", "distinct", "pathologies", "(", "C1366903#ent", "<e1>", "and", "MS", ")", "derives", "from", "a", "C0026918#ent", "<e2>", "peripheral", "nerves-leprosy", "."], "h": {"id": "C1366903", "name": "C1366903#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [23, 24]}}
{"token": ["We", "investigated", "the", "effects", "of", "early", "and", "late", "sepsis", "the", "actions", "of", "C2917437#ent", "<e1>", "using", "a", "rat", "C0243026#ent", "<e2>", "model", "induced", "by", "cecal", "ligation", "puncture", "."], "h": {"id": "C2917437", "name": "C2917437#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [17, 18]}}
{"token": ["C0162569#ent", "<e1>", "is", "characterized", "by", "a", "profound", "deficiency", "of", "C1421374#ent", "<e2>", "activity", ",", "and", "the", "disease", "is", "usually", "manifest", "in", "childhood", "."], "h": {"id": "C0162569", "name": "C0162569#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1421374", "name": "C1421374#ent", "pos": [9, 10]}}
{"token": ["These", "results", "indicate", "that", "C0001477#ent", "<e1>", "disturbances", "following", "C0033223#ent", "<e2>", "exposure", "are", "associated", "with", ")", "discrete", "alterations", "in", "IP(3", ")", "receptor-mediated", "signals", "2", ")", "activation", "of", "downstream", "events", "impact", "developing", "cortical", "cells"], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033223", "name": "C0033223#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "expression", "of", "myogenin", ",", "a", "C1417533#ent", "<e1>", "was", "not", "stimulated", "in", "the", "presence", "of", "the", "C0013227#ent", "<e2>", ",", "suggesting", "that", "it", "promotes", "membrane", "fusion", "not", "myogenic", "differentiation", "."], "h": {"id": "C1417533", "name": "C1417533#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [18, 19]}}
{"token": ["Ca", "fluxes", "and", "cell", "contraction", "studied", "in", "the", "presence", "of", "10(-4", ")", "M", "methylene", "blue", "C1417048#ent", "<e1>", ")", "which", "inhibits", "soluble", "C0018358#ent", "<e2>"], "h": {"id": "C1417048", "name": "C1417048#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018358", "name": "C0018358#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", "we", "examined", "the", "hemodynamic", "effects", "of", "methylene", "blue", "C1417048#ent", "<e1>", ")", ",", "an", "inhibitor", "of", "C0018358#ent", "<e2>", "administered", "during", "cardiopulmonary", "bypass", "CPB", ")", "to", "patients", "taking", "angiotensin-converting", "enzyme", "inhibitors"], "h": {"id": "C1417048", "name": "C1417048#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018358", "name": "C0018358#ent", "pos": [18, 19]}}
{"token": ["PSE", "is", "characterized", "by", "encephalopathy", ";", "C0037928#ent", "<e1>", "PSM", ")", "is", "characterized", "by", "C0221166#ent", "<e2>", "of", "the", "extremities", ",", "Babinski", "signs", "muscle", "spasticity", "patients", "with", "cirrhosis", "and/or", "PSS", "."], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221166", "name": "C0221166#ent", "pos": [13, 14]}}
{"token": ["In", "vitro", "C0039245#ent", "<e1>", "impaired", "DNA", "polymerase", "DNA", "replication", "and", "also", "poisoned", "topoisomerases", "I", "C3273406#ent", "<e2>", "to", "increase", "the", "relaxation", "of", "a", "supercoiled", "plasmid", "."], "h": {"id": "C0039245", "name": "C0039245#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [14, 15]}}
{"token": ["In", "erythrocytes", "of", "different", "donors", "the", "glycolysis", "characteristics", "are", "greatly", "different", "quantitatively", ",", "but", "have", "qualitatively", "similar", "C1417676#ent", "<e1>", "shape", "with", "steeply", "descending", "part", "at", "physiologically", "normal", "C2744579#ent", "<e2>", "concentration", "."], "h": {"id": "C1417676", "name": "C1417676#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [27, 28]}}
{"token": ["In", "C1704876#ent", "<e1>", ",", "autonomic", "dysfunction", "common", "and", "is", "associated", "with", "C0003405#ent", "<e2>", "or", "cerebellar", "features", ",", "or", "both", "."], "h": {"id": "C1704876", "name": "C1704876#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [11, 12]}}
{"token": ["Clinical", "and", "pathologically", "proven", "series", "document", "about", "40", "-", "60", "%", "levodopa", "efficacy", "in", "patients", "with", "C1704876#ent", "<e1>", "presenting", "with", "predominant", "C0003405#ent", "<e2>", "features", "."], "h": {"id": "C1704876", "name": "C1704876#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [21, 22]}}
{"token": ["The", "synthetic", "pathway", "involves", "synthesis", "of", "C2002119#ent", "<e1>", "and", "then", "conversion", "to", "oleamide", "by", "C0136072#ent", "<e2>", "PAM", ")", ";", "breakdown", "of", "oleamide", "is", "by", "fatty", "acid", "amide", "hydrolase", "FAAH", ")", "."], "h": {"id": "C2002119", "name": "C2002119#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0136072", "name": "C0136072#ent", "pos": [14, 15]}}
{"token": ["The", "events", "that", "precipitate", "this", "inflammatory", "reaction", "which", "may", "occur", "in", "C1562585#ent", "<e1>", "patients", ",", "and", "the", "mechanism", "by", "which", "thalidomide", "arrest", "C1334513#ent", "<e2>", ",", "are", "not", "known", "."], "h": {"id": "C1562585", "name": "C1562585#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334513", "name": "C1334513#ent", "pos": [22, 23]}}
{"token": ["The", "use", "of", "C0018549#ent", "<e1>", "inhalational", "anesthetic", "treatment", "for", "C0038218#ent", "<e2>", "widely", "known", ",", "but", "it", "has", "serious", "side", "effects", "as", "arrhythmia", "and", "liver", "injury"], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0038218", "name": "C0038218#ent", "pos": [9, 10]}}
{"token": ["Atrial", "natriuretic", "peptide", "C1417807#ent", "<e1>", ")", "is", "degraded", "by", "C0025250#ent", "<e2>", "NEP", ")", "(", "EC", "3.4.24.11", "and", "the", "kidney", "is", "a", "major", "site", "of", "C1417807#ent", "<e1>", "clearance", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [9, 10]}}
{"token": ["ALS3", "overexpression", "rescues", "the", "C1704799#ent", "<e1>", "biofilm", "defect", "in", "vivo", "thus", "arguing", "that", "C1412368#ent", "<e2>", "is", "a", "pivotal", "Bcr1", "target", "in", "this", "setting", "."], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412368", "name": "C1412368#ent", "pos": [13, 14]}}
{"token": ["Surprisingly", ",", "the", "als3/als3", "mutant", "forms", "a", "biofilm", "in", "vivo", "and", "we", "suggest", "that", "additional", "C1704799#ent", "<e1>", "targets", "compensate", "for", "the", "C1412368#ent", "<e2>", "defect", "in", "vivo"], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412368", "name": "C1412368#ent", "pos": [21, 22]}}
{"token": ["We", "report", "a", "case", "of", "C3266843#ent", "<e1>", "a", "type", "of", "Klinefelter's", "syndrome", "C2936741#ent", "<e2>", "associated", "with", "."], "h": {"id": "C3266843", "name": "C3266843#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936741", "name": "C2936741#ent", "pos": [12, 13]}}
{"token": ["At", "the", "start", "of", "the", "21st", "century", ",", "health", "technology", "assessments", "recommended", "three", "agents", "for", "the", "symptomatic", "treatment", "of", "mild", "to", "moderate", "C0002395#ent", "<e1>", "rivastigmine", ",", "donepezil", ",", "and", "C0016967#ent", "<e2>", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [22, 23]}, "relation": "may_be_treated_by", "t": {"id": "C0016967", "name": "C0016967#ent", "pos": [29, 30]}}
{"token": ["Presently", "three", "AChE", "inhibitors", "are", "approved", "for", "the", "treatment", "of", "mild", "to", "moderately", "severe", "C0002395#ent", "<e1>", "donepezil", ",", "rivastigmine", "and", "C0016967#ent", "<e2>", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0016967", "name": "C0016967#ent", "pos": [20, 21]}}
{"token": ["It", "was", "determined", "that", "stoichiometric", "concentrations", "of", "C1539715#ent", "<e1>", "and", "a", "C1334043#ent", "<e2>", "Ca2", "+", "-binding", "protein", ",", "skeletal", "muscle", "C", ",", "both", "inhibited", "and", "reversed", "microtubule", "assembly", "a", "Ca2", "+", "-dependent", "manner", "."], "h": {"id": "C1539715", "name": "C1539715#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}}
{"token": ["C1418517#ent", "<e1>", ",", "LDH", ",", "MDH", ",", "C0038838#ent", "<e2>", ",", "GOT", ",", "CA1", ",", "CA2", "and", "GPI", "were", "monomorphic", "."], "h": {"id": "C1418517", "name": "C1418517#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [7, 8]}}
{"token": ["In", "the", "C1421450#ent", "<e1>", "affected", "by", "C0038525#ent", "<e2>", "extracellular", "cisterns", "distended", "by", "intact", "of", "disintegrating", "erythrocytes", "which", "appeared", "to", "be", "natural", "tracers", "cerebrospinal", "fluid"], "h": {"id": "C1421450", "name": "C1421450#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [6, 7]}}
{"token": ["We", "observed", "a", "43-year-old", "woman", "who", "developed", "blepharospasm", "and", "oral", "hyperkinesia", "a", "C0686347#ent", "<e1>", "short-term", "treatment", "with", "C0030969#ent", "<e2>", "."], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030969", "name": "C0030969#ent", "pos": [17, 18]}}
{"token": ["Our", "data", "suggest", "a", "previously", "unidentified", "mechanism", "for", "C0023890#ent", "<e1>", "anemia", "in", "C0019202#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [12, 13]}}
{"token": ["Tyrosine", "phosphorylation", "purified", "C3272754#ent", "<e1>", "by", "C0038085#ent", "<e2>", "receptor", "tyrosine", "kinases", "in", "vitro", "enhanced", "PKC-delta", "activity", ",", "suggesting", "that", "tyrosine", "phosphorylation", "C3272754#ent", "<e1>", "may", "positively", "affect", "its", "function", "."], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3272754", "name": "C3272754#ent", "pos": [3, 4]}}
{"token": ["C0022104#ent", "<e1>", "IBS", ")", "is", "the", "world", "'s", "most", "common", "C0559031#ent", "<e2>", "is", "associated", "with", "social", "and", "economic", "costs"], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0559031", "name": "C0559031#ent", "pos": [10, 11]}}
{"token": ["Anaemia", "of", "chronic", "disease", "ACD", ")", ",", "with", "chronically", "low", "levels", "of", "circulating", "haemoglobin", ",", "is", "an", "immune", "driven", "abnormality", "occurs", "in", "many", "C0033581#ent", "<e1>", "and", "also", "in", "C0018802#ent", "<e2>"], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [28, 29]}}
{"token": ["Platelet", "activation", "a", "feature", "of", "many", "C0033581#ent", "<e1>", "as", "heparin-induced", "thrombocytopenia", "acquired", "immunodeficiency", "syndrome", "and", "C0018802#ent", "<e2>"], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["The", "results", "suggest", "that", "while", "NDP", "kinase", "associated", "with", "vimentin", "intermediate", "filaments", "an", "C1412627#ent", "<e1>", "most", "tissues", ",", "it", "interacts", "with", "energy", "metabolism", "C3540790#ent", "<e2>", "in", "a", "tissue-specific", "manner", "."], "h": {"id": "C1412627", "name": "C1412627#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [23, 24]}}
{"token": ["At", "48", "hours", "the", "analgesic", "index", "84.6", "+", "/-", "18", "units", "with", "C0731141#ent", "<e1>", "and", "49", "+", "/-", "45", "units", "with", "C0019142#ent", "<e2>", "P", "<", "0.01", ")", "."], "h": {"id": "C0731141", "name": "C0731141#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0019142", "name": "C0019142#ent", "pos": [21, 22]}}
{"token": ["Molecular", "ions", "fragment", "ions", "underivatized", "and", "permethylated", "oligosaccharides", "from", "human", "C0022478#ent", "<e1>", "some", "model", "glycoproteins", "gave", "information", "about", "the", "C0242209#ent", "<e2>", "composition", "and", "arrangement", "of", "sugars", "."], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242209", "name": "C0242209#ent", "pos": [19, 20]}}
{"token": ["Defects", "of", "individual", "C3541394#ent", "<e1>", "of", "reparation", "in", "C0033300#ent", "<e2>", ",", "Fanconi's", "anemia", "some", "other", "human", "diseases", "described", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033300", "name": "C0033300#ent", "pos": [8, 9]}}
{"token": ["Conservation", "in", "the", "position", "of", "exon/intron", "junctions", "among", "the", "mouse", "C1412433#ent", "<e1>", ",", "AOH2", ",", "aldehyde", "oxidase", "and", "xanthine", "oxidoreductase", "loci", "that", "these", "C0017337#ent", "<e2>", "are", "derived", "from", "the", "duplication", "of", "an", "ancestral", "precursor"], "h": {"id": "C1412433", "name": "C1412433#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [23, 24]}}
{"token": ["Molybdenum", "cofactor", "Moco", ")", "deficiency", "is", "a", "pleiotropic", "genetic", "disorder", "by", "the", "loss", "of", "the", "molybdenum-dependent", "enzymes", "sulphite", "oxidase", ",", "xanthine", "oxidoreductase", "C1412433#ent", "<e1>", "to", "mutations", "in", "Moco", "biosynthesis", "C0017337#ent", "<e2>", "."], "h": {"id": "C1412433", "name": "C1412433#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [29, 30]}}
{"token": ["C0025530#ent", "<e1>", "is", "a", "common", "C0043528#ent", "<e2>", "China", "."], "h": {"id": "C0025530", "name": "C0025530#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [5, 6]}}
{"token": ["C1522690#ent", "<e1>", "PLD", ")", "and", "C0069717#ent", "<e2>", "(", "LOHP", ")", "are", "active", "as", "single", "agents", "the", "treatment", "of", "recurrent", "ovarian", "cancer", "(", "ROC", ")", "."], "h": {"id": "C1522690", "name": "C1522690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0069717", "name": "C0069717#ent", "pos": [5, 6]}}
{"token": ["These", "include", "topotecan", ",", "etoposide", ",", "C1522690#ent", "<e1>", "epirubicin", ",", "gemcitabine", ",", "altretamine", ",", "C0069717#ent", "<e2>", "and", "vinorelbine", "."], "h": {"id": "C1522690", "name": "C1522690#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0069717", "name": "C0069717#ent", "pos": [14, 15]}}
{"token": ["1p36", "has", "been", "suggested", "to", "harbor", "a", "C1428945#ent", "<e1>", "and", "thought", "to", "carry", "several", "genes", "such", "as", "C3812762#ent", "<e2>", ",", "FRAP", "and", "TNF-R", "II"], "h": {"id": "C1428945", "name": "C1428945#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3812762", "name": "C3812762#ent", "pos": [17, 18]}}
{"token": ["Nuclear", "localization", "beta-catenin", "is", "observed", "in", "C1705939#ent", "<e1>", "transgenic", "mouse", "tissue", "sections", "but", "not", "in", "the", "C2987364#ent", "<e2>", ",", "age-matched", "counterparts", "."], "h": {"id": "C1705939", "name": "C1705939#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [16, 17]}}
{"token": ["Treatment", "of", "serum-deprived", "osteoblasts", ",", "isolated", "from", "either", "C1705939#ent", "<e1>", "null", "or", "C2987364#ent", "<e2>", "mice", ",", "with", "a", "PAR-4-activating", "peptide", "failed", "to", "significantly", "inhibit", "apoptosis", "compared", "to", "the", "relevant", "control", "."], "h": {"id": "C1705939", "name": "C1705939#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}}
{"token": ["The", "Mad", "family", "four", "basic-helix-loop-helix/leucine", "zipper", "proteins", "Mad1", ",", "C1334536#ent", "<e1>", ",", "Mad3", ",", "and", "Mad4", ",", "which", "heterodimerize", "with", "C0919551#ent", "<e2>", "and", "function", "as", "transcriptional", "repressors"], "h": {"id": "C1334536", "name": "C1334536#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0919551", "name": "C0919551#ent", "pos": [20, 21]}}
{"token": ["A", "second", "B-HLH-LZ", "protein", ",", "C1334536#ent", "<e1>", ",", "is", "induced", "during", "terminal", "differentiation", "and", "forms", "heterodimers", "with", "C0919551#ent", "<e2>", "that", "also", "bind", "E-boxes", "but", "tether", "the", "mSin3", "transcriptional", "repressor", "protein", "with", "histone", "deacetylase", "antagonizing", "Myc-dependent", "activation", "."], "h": {"id": "C1334536", "name": "C1334536#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919551", "name": "C0919551#ent", "pos": [17, 18]}}
{"token": ["1", ")", "C1145670#ent", "<e1>", "observed", "in", "DIC", "followed", "by", "C0041321#ent", "<e2>", "in", "far", "advanced", "cases", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041321", "name": "C0041321#ent", "pos": [9, 10]}}
{"token": ["Special", "forms", "C0220989#ent", "<e1>", "which", "in", "contrast", "to", "the", "progressive", "C0023787#ent", "<e2>", "of", "Barraquer-Simons", "spare", "the", "face", ",", "have", "been", "reported", "by", "Dunnigan", "and", "K\u00f6bberling", "."], "h": {"id": "C0220989", "name": "C0220989#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0023787", "name": "C0023787#ent", "pos": [10, 11]}}
{"token": ["The", "availability", "of", "C1420369#ent", "<e1>", "in", "suppressing", "allergen-induced", "immunoglobulin", "E", "(", "C1415975#ent", "<e2>", ")", "synthesis", ",", "airway", "inflammation", "hyperreactivity", "in", "a", "murine", "model", "was", "investigated", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [11, 12]}}
{"token": ["4", ")", "Rac1", "mutants", "defective", "in", "the", "ability", "to", "bind", "C1336674#ent", "<e1>", "or", "to", "respond", "to", "C1336674#ent", "<e1>", "by", "C0120465#ent", "<e1>", "to", "respond", "to", "C1336674#ent", "<e1>", "by", "enhanced", "oxidase", "activation", "."], "h": {"id": "C0120465", "name": "C0120465#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1336674", "name": "C1336674#ent", "pos": [10, 11]}}
{"token": ["Class", "A", "amphipathic", "helical", "peptides", "have", "been", "shown", "to", "mimic", "apolipoprotein", "A-I", "the", "major", "protein", "component", "high", "density", "lipoproteins", "have", "been", "shown", "to", "inhibit", "C0003850#ent", "<e1>", "in", "several", "C2825215#ent", "<e2>", "mouse", "models"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C2825215", "name": "C2825215#ent", "pos": [28, 29]}}
{"token": ["The", "results", "obtained", "by", "C1706048#ent", "<e1>", "were", "consistent", "with", "obtained", "by", "IIF", "with", "OKIa*1", "and", "C4049859#ent", "<e2>", "."], "h": {"id": "C1706048", "name": "C1706048#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [15, 16]}}
{"token": ["C1419805#ent", "<e1>", ",", "a", "potent", "C1413096#ent", "<e2>", "in", "human", "inflammatory", "eye", "disease", "has", "been", "chemically", "digested", "cyanogen", "bromide", "generate", "various", "peptide", "fragments"], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [5, 6]}}
{"token": ["The", "C1419805#ent", "<e1>", ",", "and", "possibly", "other", "related", "C1413096#ent", "<e2>", ",", "can", "elicit", "an", "autoimmune", "mediated", "reaction", "inflammatory", "eye", "symptoms", "."], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [8, 9]}}
{"token": ["The", "C1419805#ent", "<e1>", "is", "a", "protein", "of", "photoreceptors", ",", "mainly", "known", "for", "its", "C1413096#ent", "<e2>", "properties", "in", "mammals", ",", "which", "is", "widely", "distributed", "in", "the", "retina", "of", "vertebrates", "and", "in", "photoreceptor", "organs", "invertebrates", "."], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [13, 14]}}
{"token": ["Sodium", "valproate", "C0015043#ent", "<e1>", "are", "anticonvulsants", "employed", "in", "the", "treatment", "of", "C0014553#ent", "<e2>", "both", "drugs", "are", "considered", "to", "be", "thalamically", "active", "."], "h": {"id": "C0015043", "name": "C0015043#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [11, 12]}}
{"token": ["C0015043#ent", "<e1>", "and", "dimethadione", ",", "anticonvulsants", "effective", "in", "C0014553#ent", "<e2>", "reduced", "the", "LTCC", "when", "applied", "to", "thalamic", "neurons", "at", "clinically", "relevant", "concentrations", "."], "h": {"id": "C0015043", "name": "C0015043#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [8, 9]}}
{"token": ["New", "studies", "highlight", "the", "central", "importance", "the", "C3711161#ent", "<e1>", "ABC", ")", "transporters", "ABCA1", "and", "C1412096#ent", "<e2>", "in", "reducing", "macrophage", "foam", "cell", "formation", "inflammation", ",", "and", "atherosclerosis", "."], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412096", "name": "C1412096#ent", "pos": [14, 15]}}
{"token": ["Treatment", "of", "intact", "cells", "with", "C0531264#ent", "<e1>", "to", "stimulate", "the", "ADP-ribosylation", "of", "C1413236#ent", "<e2>", "and", "this", "modification", "was", "reversible", "."], "h": {"id": "C0531264", "name": "C0531264#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413236", "name": "C1413236#ent", "pos": [12, 13]}}
{"token": ["Studies", "have", "demonstrated", "that", "gastroesophageal", "reflux", "disease", "C0017168#ent", "<e1>", ")", "can", "cause", "sleep", "deprivation", "of", "C0018834#ent", "<e2>", "short", ",", "amnestic", "arousals", "during", "sleep", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0018834", "name": "C0018834#ent", "pos": [15, 16]}}
{"token": ["It", "is", "concluded", "that", "peristalsis", "after", "imitated", "C0017168#ent", "<e1>", "influenced", "by", "both", "the", "volume", "and", "the", "C0018834#ent", "<e2>", "of", "the", "instilled", "fluid"], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0018834", "name": "C0018834#ent", "pos": [16, 17]}}
{"token": ["All", "animals", ",", "except", "those", "sensitized", "with", "P4", "and", "C1704875#ent", "<e1>", ",", "had", "positive", "DTH", "responses", "when", "the", "C1334043#ent", "<e2>", "used", "."], "h": {"id": "C1704875", "name": "C1704875#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["UK", "and", "C1704875#ent", "<e1>", "differed", "antigenically", "from", "the", "porcine", "virus", "shown", "by", "C1334043#ent", "<e2>", ":", "heterologous", "neutralization", "titre", "ratios", "of", "30", "to", "12", "600", "."], "h": {"id": "C1704875", "name": "C1704875#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["To", "clarify", "the", "role", "of", "C3539540#ent", "<e1>", "in", "these", "cells", ",", "we", "compared", "the", "expressions", "of", "C3539540#ent", "<e1>", "mRNA", "and", "antigen", "with", "those", "of", "C0061878#ent", "<e1>", "GrB", ")", "."], "h": {"id": "C3539540", "name": "C3539540#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0061878", "name": "C0061878#ent", "pos": [24, 25]}}
{"token": ["Several", "serpins", "can", "inhibit", "apoptosis", ":", "the", "viral", "serpin", "Crm", "A", "inhibits", "Fas", "or", "TNFalpha-induced", "apoptosis", ",", "and", "overexpression", "of", "PAI-2", "or", "C3539540#ent", "<e1>", "protects", "cells", "from", "TNFalpha", "or", "C0061878#ent", "<e2>", "induced", "apoptosis", "."], "h": {"id": "C3539540", "name": "C3539540#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0061878", "name": "C0061878#ent", "pos": [29, 30]}}
{"token": ["Furthermore", ",", "we", "show", "that", "overexpression", "of", "the", "C1332017#ent", "<e1>", "FHA", "domain", "interferes", "with", "focus", "formation", "by", "C1332017#ent", "<e1>", "itself", "and", "by", "the", "C1417250#ent", "<e1>", "and", "induces", "an", "RDS", "phenotype", "."], "h": {"id": "C1332017", "name": "C1332017#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417250", "name": "C1417250#ent", "pos": [23, 24]}}
{"token": ["The", "C0265257#ent", "<e1>", "SWS", ")", "is", "a", "rare", "disorder", "characterized", "by", "C0476273#ent", "<e2>", "hyperthermic", "episodes", "and", "early", "lethality", "and", "radiologically", "by", "bowing", "of", "the", "long", "bones", "internal", "cortical", "thickening", "large", "metaphyses", "."], "h": {"id": "C0265257", "name": "C0265257#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [11, 12]}}
{"token": ["This", "study", "is", "the", "first", "antagonist", "discrimination", "in", "C1334981#ent", "<e1>", "primates", "treated", "chronically", "with", "C3536876#ent", "<e2>", "and", "the", "results", "indicate", "that", "the", "naltrexone", "stimulus", "is", "related", "to", "opioid", "withdrawal", "."], "h": {"id": "C1334981", "name": "C1334981#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536876", "name": "C3536876#ent", "pos": [14, 15]}}
{"token": ["A", "case", "of", "C0162666#ent", "<e1>", "lactic", "acidosis", "stroke-like", "episodes", "in", "which", "a", "pituitary", "growth", "hormone", "GH", ")", "C0162429#ent", "<e2>", "hypothalamic", "origin", "revealed", "through", "neuro-endocrinological", "examinations", "was", "described", "."], "h": {"id": "C0162666", "name": "C0162666#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "C0036579#ent", "<e1>", "blocks", "apoptosis", "induced", "by", "hypoxia", "as", "well", "as", "by", "C0812325#ent", "<e2>", "withdrawal", "and", "regulates", "the", "expression", "of", "apoptosis-related", "genes"], "h": {"id": "C0036579", "name": "C0036579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [15, 16]}}
{"token": ["These", "genes", ",", "designated", "abc1", ",", "abc2", ",", "and", "abc3", "encode", "an", "C0086376#ent", "<e1>", "ABC1", ")", "and", "two", "permease", "proteins", "C1412061#ent", "<e2>", "and", "ABC3", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412061", "name": "C1412061#ent", "pos": [20, 21]}}
{"token": ["This", "transporter", ",", "along", "with", "other", "C0086376#ent", "<e1>", "that", "have", "a", "high", "degree", "of", "homology", "to", "C1412061#ent", "<e2>", ",", "including", "ABCA1", "and", "ABCA7", ",", "are", "up-regulated", "in", "human", "macrophages", "during", "cholesterol", "import"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412061", "name": "C1412061#ent", "pos": [16, 17]}}
{"token": ["C0079293#ent", "<e1>", "EBA", ")", "is", "an", "acquired", "C0037274#ent", "<e2>", "by", "IgG", "autoantibodies", "against", "type", "VII", "collagen"], "h": {"id": "C0079293", "name": "C0079293#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}}
{"token": ["C0004609#ent", "<e1>", "been", "used", "to", "treat", "spasticity", "secondary", "to", "stroke", ",", "multiple", "sclerosis", "C0007789#ent", "<e2>", "spinal", "cord", "injury", "and", "other", "neurological", "disease"], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [13, 14]}}
{"token": ["To", "test", "the", "efficacy", "of", "C0004609#ent", "<e1>", "various", "movement", "disorders", "18", "patients", "with", "dystonia", ",", "head", "trauma", "C0007789#ent", "<e2>", "rigidity", ",", "or", "painful", "spasms", "a", "trial", "of", "C0004609#ent", "<e1>"], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "if", "human", "growth", "hormone", "hGH", ")", "replacement", "therapy", "C2712370#ent", "<e1>", "pharmacokinetics", "of", "hydrocortisone", "(", "CS", ")", "substitution", "in", "C0948740#ent", "<e2>", "adults", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0948740", "name": "C0948740#ent", "pos": [20, 21]}}
{"token": ["Twenty-one", "patients", "developed", "uncomplicated", "erosions", "and", "C0149745#ent", "<e1>", ",", "20", "-", "-complicated", "hemorrhages", "and", "C1422211#ent", "<e2>", "-", "-perforations", "."], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422211", "name": "C1422211#ent", "pos": [14, 15]}}
{"token": ["Among", "these", "C0031727#ent", "<e1>", "and", "substrates", "is", "C0080054#ent", "<e2>", ")", "and", "LC20", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [7, 8]}}
{"token": ["Cyclin-dependent", "kinase", "5", "Cdk5", ")", "is", "a", "proline-directed", "serine/threonine", "protein", "kinase", "requires", "association", "with", "a", "regulatory", "protein", "C1413285#ent", "<e1>", "or", "p39", ",", "to", "form", "an", "active", "C0027203#ent", "<e2>", "."], "h": {"id": "C1413285", "name": "C1413285#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [26, 27]}}
{"token": ["Cdk5", "needs", "to", "associate", "with", "one", "of", "the", "regulatory", "proteins", "C1413285#ent", "<e1>", "or", "p39", "to", "be", "an", "active", "C0027203#ent", "<e2>", "."], "h": {"id": "C1413285", "name": "C1413285#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["A", "50-year-old", "man", "who", "had", "been", "diagnosed", "as", "having", "atypical", "form", "of", "C0002986#ent", "<e1>", "of", "lower", "C0000737#ent", "<e2>", "difficult", "defection", "."], "h": {"id": "C0002986", "name": "C0002986#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [16, 17]}}
{"token": ["ANP", "has", "a", "variety", "of", "cardioprotective", "effects", "and", "is", "considered", "to", "be", "a", "very", "promising", "adjunct", "C1254351#ent", "<e1>", "for", "the", "reperfusion", "therapy", "patients", "with", "C0340293#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [24, 25]}}
{"token": ["The", "conclusion", "is", "drawn", "that", "this", "C1254351#ent", "<e1>", "could", "act", "feebly", "only", "during", "the", "earlier", "stages", "of", "C0340293#ent", "<e2>", ",", "but", "many", "reserves", "are", "expressed", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [17, 18]}}
{"token": ["C1335057#ent", "<e1>", "(", "Lyp", ")", ",", "a", "C1335055#ent", "<e2>", "is", "expressed", "exclusively", "in", "cells", "of", "hematopoietic", "origin", "notably", "in", "T", "cells", "it", "represses", "signaling", "through", "the", "T", "cell", "receptor"], "h": {"id": "C1335057", "name": "C1335057#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335055", "name": "C1335055#ent", "pos": [7, 8]}}
{"token": ["To", "investigate", "the", "identity", "of", "C1418785#ent", "<e1>", ",", "cDNAs", "encoding", "the", "pea", "homolog", "C1538830#ent", "<e2>", ",", "a", "repressor", "of", "photomorphogenesis", "identified", "in", "Arabidopsis", ",", "were", "isolated", "from", "wild-type", "and", "lip1", "pea", "seedlings", "."], "h": {"id": "C1418785", "name": "C1418785#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1538830", "name": "C1538830#ent", "pos": [13, 14]}}
{"token": ["C0524823#ent", "<e1>", "in", "vitro", "kinase", "reaction", "that", "BREK", "is", "a", "catalytically", "active", ",", "C1414387#ent", "<e2>"], "h": {"id": "C0524823", "name": "C0524823#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [13, 14]}}
{"token": ["C0524823#ent", "<e1>", "the", "radiolabeled", "NSF", "indicates", "a", "role", "for", "a", "C1414387#ent", "<e2>"], "h": {"id": "C0524823", "name": "C0524823#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [10, 11]}}
{"token": ["C0524823#ent", "<e1>", "selective", "promotion", "of", "phosphorylation", "at", "tyrosine", "but", "not", "at", "C1414387#ent", "<e2>", "."], "h": {"id": "C0524823", "name": "C0524823#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [11, 12]}}
{"token": ["Taken", "together", ",", "the", "computer-based", "T", "cell", "epitope", "prediction", "method", "could", "identify", "the", "immunogenic", "T", "cell", "epitopes", "of", "C.", "albicans", "C0812375#ent", "<e1>", "that", "promiscuously", "bind", "to", "the", "C1415576#ent", "<e2>"], "h": {"id": "C0812375", "name": "C0812375#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1415576", "name": "C1415576#ent", "pos": [27, 28]}}
{"token": ["Phosphorylation", "of", "heat", "shock", "protein", "27", "Hsp27", ")", "in", "human", "platelets", "by", "mitogen-activated", "protein", "kinase-activated", "protein", "kinase", "C1442514#ent", "<e1>", ")", "2", "is", "associated", "with", "signaling", "events", "in", "platelet", "aggregation", "regulation", "of", "C1334752#ent", "<e2>", "organization", "."], "h": {"id": "C1442514", "name": "C1442514#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334752", "name": "C1334752#ent", "pos": [31, 32]}}
{"token": ["The", "cellular", "levels", "transcripts", "from", "C0678941#ent", "<e1>", "in", "triplet", "repeat", "expansion", "diseases", "such", "as", "C0027126#ent", "<e2>", "Huntington's", "disease", "and", "spinocerebellar", "ataxia", "type", "1", "under", "Dicer", "control"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027126", "name": "C0027126#ent", "pos": [14, 15]}}
{"token": ["In", "the", "second", "study", ",", "the", "hypothesis", "that", "large", "amounts", "of", "C0012177#ent", "<e1>", "renal", "hyperfunction", "produce", "progressive", "C1417247#ent", "<e2>", "in", "dogs", "as", "previously", "reported", "in", "rats", "was", "tested", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417247", "name": "C1417247#ent", "pos": [17, 18]}}
{"token": ["The", "genetic", "defect", "Andersen's", "syndrome", "not", "C1516876#ent", "<e1>", "linked", "to", "other", "forms", "of", "C1563715#ent", "<e2>", "is", "probably", "distinct", "from", "the", "long", "QT", "syndrome", "locus", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1563715", "name": "C1563715#ent", "pos": [13, 14]}}
{"token": ["Occasional", "cases", "showed", "expression", "of", "the", "muscle", "marker", "C1413980#ent", "<e1>", "(", "2/12", ")", "and", "2", "cases", "stained", "with", "C0376515#ent", "<e2>", "."], "h": {"id": "C1413980", "name": "C1413980#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [18, 19]}}
{"token": ["The", "effect", "of", "indole-3-acetaldehyde", ",", "5-hydroxyindole-3-acetaldehyde", ",", "disulfiram", ",", "C0012422#ent", "<e1>", ",", "coprine", ",", "and", "1-amino-cyclopropanol", "on", "C1420870#ent", "<e2>", "activity", "was", "studied", "in", "vitro", "high", "performance", "liquid", "chromatography", "electro-chemical", "detection", "."], "h": {"id": "C0012422", "name": "C0012422#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [17, 18]}}
{"token": ["C3854222#ent", "<e1>", "HIV", ")", "increases", "the", "risk", "for", "anal", "premalignant", "associated", "to", "human", "C0950124#ent", "<e2>", "HPV", ")", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0950124", "name": "C0950124#ent", "pos": [13, 14]}}
{"token": ["C3854222#ent", "<e1>", "HIV", ")", "infection", "is", "a", "risk", "factor", "both", "human", "C0950124#ent", "<e2>", "HPV", ")", "and", "cervical", "squamous", "intraepithelial", "lesions", "SIL", ")", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0950124", "name": "C0950124#ent", "pos": [11, 12]}}
{"token": ["C0282556#ent", "<e1>", "classified", "into", "symptoms-modifying", ",", "symptom", "preventers", "and", "disease", "modifying", "C0991617#ent", "<e2>", "."], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "bcl-2", "(", "an", "apoptosis", "C1415142#ent", "<e1>", "showed", "a", "reciprocal", "expression", "pattern", "to", "that", "of", "C1706600#ent", "<e2>", "."], "h": {"id": "C1415142", "name": "C1415142#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706600", "name": "C1706600#ent", "pos": [16, 17]}}
{"token": ["We", "further", "demonstrate", "that", "client", "folding", "depended", "upon", "bridging", "of", "Hsp70", "and", "C3273507#ent", "<e1>", "by", "Sti1p", "and", "find", "conservation", "of", "the", "independent", "regulation", "of", "Hsp70", "and", "C3273507#ent", "<e1>", "by", "human", "C1706898#ent", "<e1>", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706898", "name": "C1706898#ent", "pos": [30, 31]}}
{"token": ["These", "morphologic", "findings", "suggest", "that", "in", "acutely", "C0740394#ent", "<e1>", "rats", "with", "a", "lesion", "comparable", "to", "C0740394#ent", "<e1>", "tubular", "blockade", "there", "is", "no", "associated", "C0268731#ent", "<e1>", "alteration", "."], "h": {"id": "C0740394", "name": "C0740394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [23, 24]}}
{"token": ["In", "conditions", "in", "which", "there", "is", "overactivity", "of", "the", "renin-angiotensin", "system", "RAS", ")", ",", "such", "as", "C0740394#ent", "<e1>", "protein", "overload", "arteriolopathy", "is", "associated", "with", "increased", "C0268731#ent", "<e2>", "reduced", "glomerular", "plasma", "flow", "results", "in", "post-glomerular", "ischemia", "and", "tubulointerstitial", "injury"], "h": {"id": "C0740394", "name": "C0740394#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [25, 26]}}
{"token": ["In", "conditions", "in", "which", "there", "is", "overactivity", "of", "the", "renin-angiotensin", "system", "RAS", ")", ",", "such", "as", "C0740394#ent", "<e1>", "protein", "overload", "arteriolopathy", "is", "associated", "with", "increased", "glomerular", "pressure", "reduced", "C0268731#ent", "<e2>", "results", "in", "post-glomerular", "ischemia", "and", "tubulointerstitial", "injury"], "h": {"id": "C0740394", "name": "C0740394#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [28, 29]}}
{"token": ["The", "1092bp", "C3715179#ent", "<e1>", "encoding", "Cel5A", "was", "C3889446#ent", "<e2>", "in", "Escherichia", "coli", "the", "corresponding", "42.1", "kDa", "protein", "purified", "using", "three-step", "chromatography", "."], "h": {"id": "C3715179", "name": "C3715179#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [7, 8]}}
{"token": ["A", "new", "sensitive", "high-performance", "liquid", "chromatographic", "method", "C0021246#ent", "<e1>", "from", "plasma", "on", "a", "reversed-phase", "column", "(", "C3889128#ent", "<e2>", ")", "has", "been", "developed", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [16, 17]}}
{"token": ["Cat", "Scratch", "Disease", "C1425926#ent", "<e1>", ")", "is", "caused", "by", "C0004771#ent", "<e2>", "is", "a", "common", "cause", "of", "regional", "lymphadenopathy"], "h": {"id": "C1425926", "name": "C1425926#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004771", "name": "C0004771#ent", "pos": [9, 10]}}
{"token": ["This", "group", "consisted", "exclusively", "of", "patients", "with", "manifest", "C3831153#ent", "<e1>", "at", "the", "time", "of", "C1419390#ent", "<e2>", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419390", "name": "C1419390#ent", "pos": [14, 15]}}
{"token": ["Today", "it", "is", "accepted", "by", "most", "thyroidologists", "that", ",", "if", "ATD", "medication", "is", "necessary", "in", "C3831153#ent", "<e1>", "it", "should", "be", "withdrawn", "at", "least", "2", "days", "before", "C1419390#ent", "<e2>", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419390", "name": "C1419390#ent", "pos": [26, 27]}}
{"token": ["C1307407#ent", "<e1>", "associated", "protein", "(", "FRAP", ",", "also", "known", "as", "C1414805#ent", "<e2>", "or", "RAFT", ")", "is", "the", "founding", "member", "of", "the", "phosphatidylinositol", "kinase-related", "kinase", "family", "functions", "as", "a", "sensor", "of", "physiological", "signals", "that", "regulate", "cell", "growth"], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414805", "name": "C1414805#ent", "pos": [10, 11]}}
{"token": ["Although", "C1318974#ent", "<e1>", "isolates", "have", "shown", "resistance", "to", "many", "antimicrobials", ",", "all", "C1318974#ent", "<e1>", "isolates", "remain", "susceptible", "to", "C0041044#ent", "<e1>", "and", "some", "of", "them", "to", "other", "common", "antimicrobials", "."], "h": {"id": "C1318974", "name": "C1318974#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [18, 19]}}
{"token": ["Present", "results", "suggest", "that", "an", "isoform", "of", "morphine", "C1412717#ent", "<e1>", "belongs", "to", "the", "UGT1", "family", "is", "C1413868#ent", "<e2>", "."], "h": {"id": "C1412717", "name": "C1412717#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413868", "name": "C1413868#ent", "pos": [16, 17]}}
{"token": ["First", ",", "itraconazole", "has", "proven", "efficacy", "for", "the", "prophylaxis", "and", "treatment", "of", "C0026946#ent", "<e1>", "immunocompromised", "individuals", "such", "as", "neutropenic", "cancer", "C3854222#ent", "<e2>", "HIV", ")", ",", "and", "solid", "organ", "transplant", "patients", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [20, 21]}}
{"token": ["Cryptococcal", "meningitis", "other", "serious", "C0026946#ent", "<e1>", "common", "complications", "in", "patients", "infected", "with", "the", "C3854222#ent", "<e2>", "HIV", ")", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [13, 14]}}
{"token": ["Aspergillosis", "is", "a", "life-threatening", "C0026946#ent", "<e1>", "immunocompromised", "people", ",", "including", "people", "infected", "with", "C3854222#ent", "<e2>", "HIV", ")", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "the", "C3273648#ent", "<e1>", "in", "Japanese", "subjects", "with", "C0011860#ent", "<e2>", "and", "appear", "to", "be", "an", "important", "cause", "of", "early-onset", "C0011860#ent", "<e2>", "in", "this", "population", "."], "h": {"id": "C3273648", "name": "C3273648#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [9, 10]}}
{"token": ["Two", "sexual", "side", "associated", "with", "C0040805#ent", "<e1>", "have", "been", "reported", ":", "C0033117#ent", "<e2>", "in", "men", "and", "increased", "libido", "in", "women", "."], "h": {"id": "C0040805", "name": "C0040805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033117", "name": "C0033117#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "a", "physician", "who", "successfully", "treated", "his", "impotence", "for", "the", "last", "4", "years", "with", "C0040805#ent", "<e1>", ",", "an", "antidepressant", "that", "may", "induce", "C0033117#ent", "<e2>", "."], "h": {"id": "C0040805", "name": "C0040805#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033117", "name": "C0033117#ent", "pos": [23, 24]}}
{"token": ["The", "author", "'s", "own", "regimen", "is", "to", "use", "combinations", "of", "C0014710#ent", "<e1>", "either", "verapamil", "or", "prednisone", "in", "episodic", "cluster", "headache", "with", "lithium", "for", "C0009088#ent", "<e2>"], "h": {"id": "C0014710", "name": "C0014710#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0009088", "name": "C0009088#ent", "pos": [23, 24]}}
{"token": ["One", "of", "the", "major", "cytotoxic", "lesions", "by", "alkylating", "agents", "C0171196#ent", "<e1>", "which", "can", "be", "excised", "by", "3-alkyladenine", "DNA", "glycosylase", "C1417239#ent", "<e2>", ")", "."], "h": {"id": "C0171196", "name": "C0171196#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417239", "name": "C1417239#ent", "pos": [19, 20]}}
{"token": ["In", "an", "in", "vitro", "assay", "the", "hbrm", "protein", "not", "be", "cleaved", "by", "caspase-3", ",", "-7", ",", "or", "-6", ",", "the", "\"", "effector", "\"", "C0010656#ent", "<e1>", "generally", "believed", "to", "carry", "out", "the", "cleavage", "of", "C1837033#ent", "<e2>"], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1837033", "name": "C1837033#ent", "pos": [33, 34]}}
{"token": ["Autoimmune", "disease", "be", "divided", "into", "either", "organ-specific", "illnesses", ",", "such", "as", "C0040128#ent", "<e1>", "type", "1", "diabetes", "and", "mysasthenia", "gravis", ",", "or", "C0221423#ent", "<e2>", "such", "as", "rheumatoid", "arthritis", "systemic", "lupus", "erythematosus"], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [21, 22]}}
{"token": ["C1136632#ent", "<e1>", "also", "down-regulated", "the", "level", "of", "C0243045#ent", "<e2>", "6", "and", "up-regulated", "cell", "cycle-dependent", "kinase", "inhibitor", "p27(Kip1", ")", "protein", "without", "an", "effect", "on", "the", "level", "of", "Erk", "and", "Hsp90", "proteins"], "h": {"id": "C1136632", "name": "C1136632#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [7, 8]}}
{"token": ["This", "is", "a", "case", "history", "a", "patient", "with", "C0574084#ent", "<e1>", "the", "characteristics", "of", "this", "C0039082#ent", "<e2>", "and", "the", "gene", "that", "causes", "this", "disease", "."], "h": {"id": "C0574084", "name": "C0574084#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}}
{"token": ["Our", "data", "suggest", "that", "C1705887#ent", "<e1>", "and", "CLDN4", "are", "critical", "C0127400#ent", "<e2>", "of", "the", "antiproliferative", "and", "antiviral", "effects", "type", "I", "and", "further", "confirm", "the", "functional", "importance", "of", "the", "DNA-binding", "domain", "Stat2", "."], "h": {"id": "C1705887", "name": "C1705887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [10, 11]}}
{"token": ["Application", "of", "C0991617#ent", "<e1>", "used", "for", "diabetic", "neuropathy", "that", "evening", "C0700602#ent", "<e2>", "alpha-lipoic", "acid", "and", "capsaicin", "may", "all", "play", "a", "role", "in", "the", "empiric", "options", "available", "to", "patients", "with", "chemotherapy-induced", "neuropathy"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700602", "name": "C0700602#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "PD", "patients", "with", "the", "-1031C", "C0002085#ent", "<e1>", "showed", "a", "significantly", "earlier", "onset", "than", "those", "without", "-1031C", "C0002085#ent", "<e1>", ",", "after", "stratification", "of", "the", "data", "by", "an", "C1708431#ent", "<e1>", "polymorphism", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1708431", "name": "C1708431#ent", "pos": [29, 30]}}
{"token": ["The", "other", "locus", "encodes", "a", "protein", "that", "is", "C1512488#ent", "<e1>", "to", "the", "S.", "cerevisiae", "CDC25", "protein", "an", "activator", "of", "C1414292#ent", "<e2>", "ras", "proteins"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414292", "name": "C1414292#ent", "pos": [19, 20]}}
{"token": ["Atropine", ",", "C0138666#ent", "<e1>", "and", "M-6", "significantly", "shifted", "the", "cumulative", "concentration-response", "curves", "C0006945#ent", "<e2>", "(", "CCh", ")", "to", "higher", "concentrations", "."], "h": {"id": "C0138666", "name": "C0138666#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [12, 13]}}
{"token": ["Tizanidine", "(", "C0771735#ent", "<e1>", "is", "a", "new", "C0026838#ent", "<e2>", "has", "purported", "central", "action"], "h": {"id": "C0771735", "name": "C0771735#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0026838", "name": "C0026838#ent", "pos": [7, 8]}}
{"token": ["The", "presence", "of", "putative", "folate", "transporter", "in", "the", "Toxoplasma", "genome", ",", "which", "are", "homologous", "to", "the", "BT1", "family", "of", "C0086376#ent", "<e1>", ",", "suggests", "that", "Toxoplasma", "may", "encode", "C0086376#ent", "<e1>", "involved", "in", "C1420117#ent", "<e1>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420117", "name": "C1420117#ent", "pos": [31, 32]}}
{"token": ["The", "transepithelial", "PMN", "migration", "could", "be", "blocked", "by", "an", "C2981844#ent", "<e1>", "MAb", ")", "but", "not", "by", "MAbs", "against", "C1366571#ent", "<e2>", "."], "h": {"id": "C2981844", "name": "C2981844#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [18, 19]}}
{"token": ["Prostatitis", ",", "the", "C2936328#ent", "<e1>", "after", "benign", "prostatic", "hypertrophy", "prostate", "cancer", "is", "the", "last", "frontier", "of", "C0033575#ent", "<e2>"], "h": {"id": "C2936328", "name": "C2936328#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033575", "name": "C0033575#ent", "pos": [16, 17]}}
{"token": ["The", "(+)-isomer", "of", "C0073751#ent", "<e1>", "was", "more", "potent", "and", "the", "C0037760#ent", "<e2>", "was", "less", "potent", "than", "C0073751#ent", "<e1>", "for", "antagonistic", "action", "U-46619", "."], "h": {"id": "C0073751", "name": "C0073751#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037760", "name": "C0037760#ent", "pos": [10, 11]}}
{"token": ["The", "data", "further", "suggest", "that", "C0023524#ent", "<e1>", "may", "contribute", "to", "an", "E2F-independent", "tumor", "suppressor", "function", "of", "C1334895#ent", "<e2>", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334895", "name": "C1334895#ent", "pos": [16, 17]}}
{"token": ["However", ",", "neither", "NB", "formation", "nor", "C0023524#ent", "<e1>", "function", "were", "required", "for", "C1334895#ent", "<e2>", "to", "induce", "the", "senescence-like", "response", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334895", "name": "C1334895#ent", "pos": [12, 13]}}
{"token": ["These", "and", "the", "first", "quantitative", "studies", "the", "interaction", "of", "a", "new", "vinca", "alkaloid", "derivative", "C0377401#ent", "<e1>", "(", "Navelbine", ")", ",", "with", "other", "C0042672#ent", "<e2>"], "h": {"id": "C0377401", "name": "C0377401#ent", "pos": [14, 15]}, "relation": "has_chemical_structure", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [22, 23]}}
{"token": ["After", "pigeon", "were", "submitted", "either", "to", "lipopolysaccharide", "(", "C0175697#ent", "<e1>", ")", "infection", "or", "iron-dextran", "stimulation", ",", "the", "C1423607#ent", "<e2>", "transcript", "levels", "were", "analyzed", "by", "a", "comparative", "RT-PCR"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1423607", "name": "C1423607#ent", "pos": [17, 18]}}
{"token": ["A", "methyl", "group", "introduced", "in", "the", "alpha-position", "of", "palmitic", "acid", "TTA", ",", "EPA", ",", "C2348308#ent", "<e1>", ",", "cis9,trans11", "C4283784#ent", "<e2>", ",", "and", "trans10,cis12", "C4283784#ent", "<e2>", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [18, 19]}}
{"token": ["This", "review", "summarizes", "the", "C4283784#ent", "<e1>", "and", "cancer", "literature", "then", "uses", "the", "evidence", "for", "the", "anticancer", "immune", "tumor", "properties", "of", "the", "C2348308#ent", "<e2>", "eicosapentaenoic", "acids", "suggest", "future", "research", "directions", "for", "mechanistic", "studies", "C4283784#ent", "<e1>", "and", "cancer", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [4, 5]}}
{"token": ["C0405580#ent", "<e1>", "(", "primary", "or", "secondary)", "an", "uncommon", "C0014130#ent", "<e2>", "most", "commonly", "in", "young-to-middle-aged", "female", "dogs", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [8, 9]}}
{"token": ["In", "the", "present", "study", ",", "we", "were", "also", "unable", "to", "observe", "any", "effect", "of", "either", "ANP", "or", "C1537501#ent", "<e1>", "in", "the", "SS", "rat", "C2984559#ent", "<e2>", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2984559", "name": "C2984559#ent", "pos": [23, 24]}}
{"token": ["Recently", ",", "we", "found", "that", "C0599295#ent", "<e1>", ",", "an", "Ets", "family", "member", "activates", "collagenase-1", "gene", "not", "C0164371#ent", "<e2>", "by", "physically", "interacting", "with", "c-Fos/c-Jun", "."], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "we", "show", "that", "two", "members", "of", "the", "Ets-family", ",", "Ets2", "and", "C0599295#ent", "<e1>", "and", "their", "combinations", "differentially", "regulate", "collagenase1", "and", "C0164371#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [22, 23]}}
{"token": ["In", "transiently", "transfected", "cells", ",", "Ets2", "activates", "both", "promoters", "whereas", "C0599295#ent", "<e1>", "induces", "collagenase1", "but", "not", "C0164371#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [16, 17]}}
{"token": ["To", "elucidate", "the", "regulation", "of", "obese", "(", "ob", ")", "gene", "expression", "obesity", "and", "C0011847#ent", "<e1>", ",", "we", "examined", "C2986870#ent", "<e2>", "in", "KK", "mice", "and", "congenic", "lethal", "yellow", "obese", "KKAy", "mice", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2986870", "name": "C2986870#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "whether", "the", "angiotensin-converting-enzyme", "(ACE)", "inhibitor", "C0072973#ent", "<e1>", "can", "lower", "these", "risks", "in", "patients", "with", "C0011849#ent", "<e2>", "."], "h": {"id": "C0072973", "name": "C0072973#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [16, 17]}}
{"token": ["Ceftriaxone", "was", "given", "once", "daily", "to", "children", "with", "C0597039#ent", "<e1>", "once", "or", "twice", "daily", "intravenously", "to", "children", "with", "C0025297#ent", "<e2>", "."], "h": {"id": "C0597039", "name": "C0597039#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [18, 19]}}
{"token": ["Regarding", "inhibitory", "effects", "of", "other", "C0003290#ent", "<e1>", "imipramine", "and", "setiptiline", "were", "found", "to", "markedly", "inhibit", "C0022614#ent", "<e2>", "current", ",", "while", "maprotiline", ",", "amitriptyline", "and", "lofepramine", "slightly", "inhibited", "the", "current", "."], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [15, 16]}}
{"token": ["Animal", "studies", "suggested", "that", "many", "C0003290#ent", "<e1>", "activity", "at", "the", "NMDA", "receptor", "that", "C0022614#ent", "<e2>", "antagonists", "have", "antidepressant", "profiles", "preclinical", "models", "depression", "."], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [13, 14]}}
{"token": ["Neither", "antisera", "recognized", "YP-related", "di-", "or", "C0012512#ent", "<e1>", "or", "YGGF-related", "opioid", "sequences", "(", "enkephalins", ",", "C1337111#ent", "<e2>", ",", "dynorphin", ")", "."], "h": {"id": "C0012512", "name": "C0012512#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [15, 16]}}
{"token": ["Post-source", "decay", "(", "C1418984#ent", "<e1>", ")", "was", "used", "to", "resolve", "standard", "isomers", "C3811118#ent", "<e2>", "(", "e.g.", "18:1/18:1", "vs.", "18:0/18:2", ")", "."], "h": {"id": "C1418984", "name": "C1418984#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [12, 13]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "evaluate", "in", "vivo", "C0003195#ent", "<e1>", "effects", "of", "C0123053#ent", "<e2>", "in", "dogs", "with", "or", "without", "ventricular", "hypertrophy"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [10, 11]}, "relation": "therapeutic_class_of", "t": {"id": "C0123053", "name": "C0123053#ent", "pos": [14, 15]}}
{"token": ["Taken", "together", ",", "these", "results", "suggest", "that", "LIF", "strongly", "inhibited", "early", "C2986638#ent", "<e1>", "differentiation", "though", "activation", "of", "the", "C1370600#ent", "<e2>", "signaling", "pathway", "its", "effect", "is", "irrespective", "of", "glycosylation", "."], "h": {"id": "C2986638", "name": "C2986638#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [18, 19]}}
{"token": ["The", "expression", "of", "this", "molecule", "was", "inducible", "on", "the", "C4284230#ent", "<e1>", "lymphocytes", "with", "C0022265#ent", "<e2>"], "h": {"id": "C4284230", "name": "C4284230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "we", "show", "that", "C1420470#ent", "<e1>", "is", "homologous", "to", "the", "N", "terminus", "of", "human", "C1419243#ent", "<e2>", "."], "h": {"id": "C1420470", "name": "C1420470#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419243", "name": "C1419243#ent", "pos": [17, 18]}}
{"token": ["The", "increase", "in", "plasma", "nicotine", "concentration", "during", "exercise", "is", "similar", "to", "that", "observed", "for", "C0699222#ent", "<e1>", "and", "may", "be", "related", "to", "an", "C0004099#ent", "<e2>", "increase", "in", "blood", "flow", "the", "patch", "area"], "h": {"id": "C0699222", "name": "C0699222#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [22, 23]}}
{"token": ["These", "results", "indicated", "that", "C0526871#ent", "<e1>", "activation", "through", "its", "C1422492#ent", "<e2>", ",", "MT-MMP", ",", "is", "a", "physiological", "system", "by", "organisms", "to", "initiate", "tissue", "remodeling", "the", "cell", "surface"], "h": {"id": "C0526871", "name": "C0526871#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [9, 10]}}
{"token": ["These", "studies", "suggest", "that", "in", "C0598428#ent", "<e1>", "rats", ",", "both", "the", "magnitude", "and", "C2926735#ent", "<e2>", "of", "the", "hypertension", "are", "important", "determinants", "of", "the", "degree", "of", "hypertrophy", "and", "the", "functional", "status", "the", "ventricle", "."], "h": {"id": "C0598428", "name": "C0598428#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [13, 14]}}
{"token": ["Of", "the", "chemicals", "tested", ",", "C0034239#ent", "<e1>", "was", "the", "most", "potent", "and", "inhibited", "both", "C1861821#ent", "<e2>", "and", "embryo", "growth", "picomolar", "doses", "."], "h": {"id": "C0034239", "name": "C0034239#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1861821", "name": "C1861821#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "C0036753#ent", "<e1>", "affect", "synthesis", "in", "5-hydroxytryptamine", "and/or", "dopamine", "neurons", "after", "C0041260#ent", "<e2>", "treatment", "and", "aromatic-l-amino", "acid", "decarboxylase", "inhibition", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041260", "name": "C0041260#ent", "pos": [14, 15]}}
{"token": ["To", "assess", "cost-effectiveness", "of", "C1619966#ent", "<e1>", "in", "patients", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "with", "inadequate", "response", "to", "tumor", "necrosis", "factor-alpha", "antagonists", "anti-TNF", ")", "."], "h": {"id": "C1619966", "name": "C1619966#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}}
{"token": ["The", "order", "of", "potency", "for", "full", "(", "F", ")", "or", "partial", "(", "P", ")", "C2987634#ent", "<e1>", "causing", "relaxation", "was", "C0733381#ent", "<e2>", "(", "P", ")", ">"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0733381", "name": "C0733381#ent", "pos": [19, 20]}}
{"token": ["In", "vitro", "assessment", "of", "C1425131#ent", "<e1>", "and", "hCEPT1", "derived", "C3537380#ent", "<e2>", "revealed", "differences", "in", "diradylglycerol", "specificities", "including", "their", "capacity", "to", "synthesize", "platelet-activating", "factor", "platelet-activating", "factor", "precursor"], "h": {"id": "C1425131", "name": "C1425131#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537380", "name": "C3537380#ent", "pos": [9, 10]}}
{"token": ["Since", "both", "the", "C1425131#ent", "<e1>", "and", "EPT1", "gene", "products", "the", "C3537380#ent", "<e2>", "in", "vitro", "Hjelmstad", ",", "R.", "H.", ",", "and", "Bell", ",", "R.", "M.", "(", "1991", ")", "J.", "Biol", "."], "h": {"id": "C1425131", "name": "C1425131#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537380", "name": "C3537380#ent", "pos": [10, 11]}}
{"token": ["The", "findings", "also", "suggested", "that", "in", "the", "salivary", "gland", "tissue", "epithelial", "cells", "mainly", "contained", "the", "54", "C1839259#ent", "<e1>", "C0010803#ent", "<e2>", "and", "the", "epithelial", "cells", "mainly", "contained", "57/66", "C1839259#ent", "<e1>", "C0010803#ent", "<e2>", "were", "the", "origin", "of", "the", "salivary", "gland", "tumors"], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [16, 17]}}
{"token": ["Involved", "epidermis", "contains", "decreased", "amounts", "of", "C0010803#ent", "<e1>", "MW", "69", ",", "66.5", "and", "65.2", "C1839259#ent", "<e2>", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [14, 15]}}
{"token": ["Ependymal", "cells", "GFAP", "and", "vimentin", "filaments", ",", "whereas", "epithelial", "plexus", "cells", "C0010803#ent", "<e1>", ",", "vimentin", "and", "neurofilament", "200", "C1839259#ent", "<e2>", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [18, 19]}}
{"token": ["Liver", "carnitine", "palmitoyltransferase", "I", "CPT", "I", ",", "the", "rate-limiting", "enzyme", "of", "C3658275#ent", "<e1>", "rapidly", "loses", "its", "activity", "when", "C0669372#ent", "<e2>", "are", "put", "in", "culture", "."], "h": {"id": "C3658275", "name": "C3658275#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}}
{"token": ["Expression", "of", "IL-6", "and", "IL-8", "was", "sensitive", "to", "SB203580", ",", "the", "specific", "inhibitor", "of", "p38", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e1>", "and", "PD98059", ",", "an", "inhibitor", "of", "C0169101#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [27, 28]}}
{"token": ["It", "was", "subsequently", "established", "that", "variation", "of", "the", "substituents", "on", "the", "4-anilino", "group", "of", "the", "6,7-dimethoxy-3-quinolinecarbonitrile", "changed", "the", "kinase", "specificity", "EGFr", "to", "other", "C0031727#ent", "<e1>", "including", "Src", "and", "C0169101#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [23, 24]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [28, 29]}}
{"token": ["We", "now", "demonstrate", "that", "Mirk", "is", "activated", "as", "a", "C0031727#ent", "<e1>", "by", "signaling", "from", "Rac1", "to", "the", "C0169101#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [17, 18]}}
{"token": ["A", "gene", "fusion", "system", "on", "plasmid", "pBBR1MCS", "and", "the", "expression", "of", "green", "fluorescent", "protein", "developed", "for", "C0275594#ent", "<e1>", "allowing", "isolation", "of", "constitutive", "and", "inducible", "C0017337#ent", "<e2>", "."], "h": {"id": "C0275594", "name": "C0275594#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}}
{"token": ["The", "co-expression", "of", "osteocalcin", "(", "C1412791#ent", "<e1>", ")", "with", "the", "capsaicin", "receptor", "VR1", ")", "and", "vanilloid", "receptor", "1-like", "receptor", "C1425290#ent", "<e2>", ")", "was", "examined", "in", "the", "dorsal", "root", "DRG", ")", "and", "trigeminal", "ganglia", "TG", ")", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425290", "name": "C1425290#ent", "pos": [19, 20]}}
{"token": ["Ventriculostomy", ",", "used", "for", "therapy", "of", "C0009451#ent", "<e1>", "can", "cause", "complications", "such", "as", "C1366535#ent", "<e2>"], "h": {"id": "C0009451", "name": "C0009451#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "the", "hypha-specific", "genes", "examined", "depends", "on", "the", "C1956039#ent", "<e1>", "in", "the", "C1539560#ent", "<e2>", "and", "Tec1", "transcription", "factors", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539560", "name": "C1539560#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "exposure", "of", "spinal", "cord", "neurons", "to", "phorbol-12-myristate-13-acetate", "(", "PMA", ")", ",", "an", "activator", "of", "C3539645#ent", "<e1>", ",", "mimicked", "AA-induced", "stimulation", "of", "C0124604#ent", "<e2>", "activity", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [24, 25]}}
{"token": ["Finally", ",", "basal", "C0124604#ent", "<e1>", "phosphorylation", "in", "neurons", "is", "mediated", "predominantly", "by", "C3539645#ent", "<e2>", "at", "Ser-476", ",", "with", "C3539645#ent", "<e2>", "activation", "increasing", "phosphorylation", "at", "Ser-440", "and", "enhancing", "C0124604#ent", "<e1>", "activity", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [3, 4]}}
{"token": ["Using", "isogenic", "laboratory", "strains", ",", "we", "confirm", "that", "this", "C1706112#ent", "<e1>", "causes", "dramatic", "differences", "in", "gene-expression", "levels", "of", "key", "C1417679#ent", "<e2>", "involved", "in", "amino", "acid", "biosynthesis"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [19, 20]}}
{"token": ["Genetic", "and", "phenotypic", "analysis", "the", "abrD1", "mutation", "demonstrates", "that", "it", "is", "an", "C1706112#ent", "<e1>", "Thus", ",", "aidB", "is", "a", "member", "of", "the", "family", "of", "C1417679#ent", "<e2>", "that", "are", "transcribed", "by", "a", "sigma", "S-directed", "RNA", "polymerase", "holoenzyme"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["The", "Hbb(d", ")", "C1706112#ent", "<e1>", "at", "the", "hemoglobin", "beta", "chain", "locus", "Mus", "musculus", "composed", "of", "two", "linked", "C1417679#ent", "<e2>", ",", "coding", "for", "structurally", "different", "beta", "chains", "betadmin", "and", "betadmaj", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["Over", "a", "24", "hour", "period", ",", "the", "following", "symptoms", "could", "be", "observed", ":", "akathisia", ",", "circling", ",", "C0085623#ent", "<e1>", ",", "choreoathetoid", "and", "dystonic", "movements", "C0013384#ent", "<e2>", "postural", "tremor", "or", "without", "harmaline", "."], "h": {"id": "C0085623", "name": "C0085623#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [24, 25]}}
{"token": ["Diallyl", "trisulfide", "C0002395#ent", "<e1>", ")", ",", "diallyl", "sulfide", "DAS", ")", ",", "and", "C0057695#ent", "<e2>", "DADS", ")", "are", "the", "three", "major", "organosulfur", "compounds", "OSCs", ")", "in", "garlic", "oil"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0057695", "name": "C0057695#ent", "pos": [12, 13]}}
{"token": ["It", "has", "cosmetic", "aims", "in", "the", "early", "stages", "the", "disease", ",", "and", "palliative", "ones", "reduce", "C0234233#ent", "<e1>", "and", "associated", "C0013604#ent", "<e2>", "in", "the", "lesions", "of", "a", "more", "advanced", "disease"], "h": {"id": "C0234233", "name": "C0234233#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [19, 20]}}
{"token": ["Cyclosporine", "(", "C0751039#ent", "<e1>", ")", "is", "an", "inhibitor", "of", "ornithine", "decarboxylase", "C0029282#ent", "<e2>", ")", ",", "a", "key", "enzymatic", "step", "in", "cell", "proliferation"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [11, 12]}}
{"token": ["Hermansky-Pudlak", "syndrome", "HPS", ")", "is", "a", "rare", "C3899988#ent", "<e1>", "inherited", "disorder", "of", "the", "triad", "of", "C0268495#ent", "<e2>", "prolonged", "bleeding", "time", "secondary", "to", "platelet", "storage", "pool", "defect", "ceroid", "depositions", "within", "the", "reticuloendothelial", "system"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268495", "name": "C0268495#ent", "pos": [15, 16]}}
{"token": ["The", "Hermansky-Pudlak", "syndrome", "HPS", ")", "is", "a", "rare", "genetically", "heterogeneous", "C3899988#ent", "<e1>", "characterized", "by", "C0268495#ent", "<e2>", "platelet", "dysfunction", "lysosomal", "ceroid", "lipofuscin", "storage", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268495", "name": "C0268495#ent", "pos": [14, 15]}}
{"token": ["Hermansky-Pudlak", "syndrome", "HPS", ")", "is", "an", "C3899988#ent", "<e1>", "by", "the", "triad", "of", "C0268495#ent", "<e2>", "bleeding", "diathesis", "to", "storage-pool", "deficiency", "platelets", ",", "and", "a", "lysosomal", "ceroid", "storage", "disease"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268495", "name": "C0268495#ent", "pos": [12, 13]}}
{"token": ["Epilepsy", "was", "present", "in", "4", "of", "19", "patients", "with", "C1419249#ent", "<e1>", "and", "GAD-A", ",", "implying", "that", "C0014547#ent", "<e2>", "sometimes", "is", "associated", "with", "anti-GAD", "autoimmunity"], "h": {"id": "C1419249", "name": "C1419249#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [16, 17]}}
{"token": ["A", "patient", "is", "described", "whose", "clinical", "course", "pathologic", "features", "including", "massive", "brain", "storage", "GM2", "ganglioside", "grey", "matter", "are", "identical", "with", "those", "of", "C0268275#ent", "<e1>", "normal", "levels", "of", "beta", "-N-acetyl", "hexosaminidase", "normal", "C0022173#ent", "<e2>", "distribution", "."], "h": {"id": "C0268275", "name": "C0268275#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [31, 32]}}
{"token": ["At", "the", "OPL", ",", "C1422145#ent", "<e1>", "is", "essential", "for", "correct", "localization", "of", "Psd95", "and", "C1425077#ent", "<e2>", "at", "the", "presynaptic", "photoreceptor", "membrane"], "h": {"id": "C1422145", "name": "C1422145#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425077", "name": "C1425077#ent", "pos": [14, 15]}}
{"token": ["A", "24-h", "exposure", "to", "TBT", "or", "C1413756#ent", "<e1>", "decreased", "intracellular", "C1705556#ent", "<e2>", "levels", "by", "about", "30", "%", "."], "h": {"id": "C1413756", "name": "C1413756#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["Distinct", "methylation", "patterns", "were", "further", "seen", "in", "MT1J", "and", "C1417389#ent", "<e1>", ",", "belonging", "to", "the", "C1334534#ent", "<e2>"], "h": {"id": "C1417389", "name": "C1417389#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334534", "name": "C1334534#ent", "pos": [15, 16]}}
{"token": ["Two", "newly", "induced", "C0086376#ent", "<e1>", "were", "identified", "as", "malate", "dehydrogenase", "orthologue", "C0027293#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027293", "name": "C0027293#ent", "pos": [11, 12]}}
{"token": ["The", "C0006684#ent", "<e1>", "azelnidipine", "attenuated", "the", "later", "peaks", "of", "C4082284#ent", "<e2>", "ERK", ")", ",", "tyrosine", "kinase", "2", "Jak2", "activation", ",", "and", "phosphorylation", "of", "signal", "transducer", "activator", "of", "transcription", "and", "STAT3", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [9, 10]}}
{"token": ["C0031887#ent", "<e1>", "dependent", "on", "the", "RNA", "poly(A)", "tail", "which", "binds", "the", "poly(A)", "binding", "protein", "C1442738#ent", "<e2>", ")", "."], "h": {"id": "C0031887", "name": "C0031887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1442738", "name": "C1442738#ent", "pos": [14, 15]}}
{"token": ["The", "salt", "threshold", "value", "was", "measured", "in", "60", "patients", "with", "C0085580#ent", "<e1>", "60", "patients", "with", "C0018802#ent", "<e2>", "40", "normal", "subjects"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["METHODS", "AND", "RESULTS", ":", "Carvedilol", "is", "licensed", "for", "the", "treatment", "of", "C0085580#ent", "<e1>", "chronic", "stable", "angina", "and", "mild", "to", "moderate", "C0018802#ent", "<e2>"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["Results", "show", "that", "the", "enzyme", "systems", "differ", "from", "DT-diaphorase", ",", "C0051124#ent", "<e1>", "xanthine", "oxidase", "ketone", "reductase", "aldose", "reductase", "aldehyde", "reductase", "alcohol", "dehydrogenase", "known", "cytosolic", "C3540772#ent", "<e2>", "responsible", "for", "xenobiotic", "metabolism"], "h": {"id": "C0051124", "name": "C0051124#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [24, 25]}}
{"token": ["Molybdenum", "cofactor", "deficiency", "characterized", "by", "the", "absence", "of", "sulphite", "oxidase", "xanthine", "dehydrogenase", "C0051124#ent", "<e1>", "the", "three", "known", "C3540772#ent", "<e2>", "in", "man", "that", "require", "the", "cofactor", "for", "their", "activity", "."], "h": {"id": "C0051124", "name": "C0051124#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [17, 18]}}
{"token": ["A", "number", "of", "biochemical", "and", "genetic", "features", "by", "C0051124#ent", "<e1>", "pyridoxal", "oxidase", "Drosophila", "melanogaster", "a", "close", "relationship", "between", "these", "C3540772#ent", "<e2>", "."], "h": {"id": "C0051124", "name": "C0051124#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [19, 20]}}
{"token": ["Consistent", "with", "this", ",", "As(2)O(3)-dependent", "pro-apoptotic", "effects", "are", "enhanced", "in", "double", "knock-out", "cells", "for", "both", "isoforms", "of", "the", "C1136240#ent", "<e1>", "S6k1/S6k2", ")", ",", "a", "downstream", "effector", "of", "C0164786#ent", "<e2>", "and", "mTOR", "."], "h": {"id": "C1136240", "name": "C1136240#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [27, 28]}}
{"token": ["Very", "similar", "results", "were", "observed", "with", "two", "C0002085#ent", "<e1>", "forms", "of", "human", "C1142644#ent", "<e2>", "P450", "NF25", "and", "P450", "hPCN1", ",", "produced", "in", "yeast", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}}
{"token": ["We", "report", "the", "mapping", "of", "the", "human", "and", "mouse", "genes", "SEK1", "(", "C1417008#ent", "<e1>", ",", "a", "newly", "identified", "C0010536#ent", "<e2>", "is", "a", "potent", "physiological", "activator", "of", "the", "stress-activated", "protein", "kinases"], "h": {"id": "C1417008", "name": "C1417008#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [18, 19]}}
{"token": ["Non-allergic", "rhinitis", "C0272191#ent", "<e1>", "NARES", ")", "accounts", "for", "14", "%", "of", "C0035455#ent", "<e2>", "."], "h": {"id": "C0272191", "name": "C0272191#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [11, 12]}}
{"token": ["Four", "clinical", "cases", "presented", "illustrating", "some", "of", "the", "underlying", "\"", "treatable", "\"", "causes", "of", "heart", "failure", "C0221155#ent", "<e1>", "iatrogenic", "hypophosphatemia", ",", "chronic", "alcoholism", "C1384665#ent", "<e2>", "."], "h": {"id": "C0221155", "name": "C0221155#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1384665", "name": "C1384665#ent", "pos": [23, 24]}}
{"token": ["We", "find", "that", "C1420279#ent", "<e1>", "overexpression", "increases", "both", "C3815527#ent", "<e2>", "and", "Delta", "transcription", "though", "C1420279#ent", "<e1>", "expression", "alone", "is", "not", "sufficient", "to", "activate", "Delta", "protein", "function"], "h": {"id": "C1420279", "name": "C1420279#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3815527", "name": "C3815527#ent", "pos": [8, 9]}}
{"token": ["To", "examine", "whether", "excessive", "protein", "O-GlcNAcylation", "a", "role", "in", "the", "dysfunction", "of", "the", "C3534591#ent", "<e1>", "we", "delivered", "C0001486#ent", "<e2>", "expressing", "O-GlcNAcase", "(", "Adv-GCA", ")", "into", "the", "myocardium", "of", "STZ-induced", "diabetic", "mice"], "h": {"id": "C3534591", "name": "C3534591#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [17, 18]}}
{"token": ["We", "determined", "the", "effects", "of", "C1413756#ent", "<e1>", "on", "blood", "lipid", "expression", "of", "C1417679#ent", "<e2>", "related", "to", "foam", "cell", "formation", "the", "early", "stage", "atherosclerosis", "in", "diabetic", "GK", "rats", "."], "h": {"id": "C1413756", "name": "C1413756#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["The", "results", "demonstrated", "that", "C1413756#ent", "<e1>", "could", "regulate", "blood", "lipid", "inhibit", "the", "C1417679#ent", "<e2>", "expression", "of", "MCP-1", ",", "ICAM-1", "and", "CD36", "in", "aorta", "."], "h": {"id": "C1413756", "name": "C1413756#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Frameshift", "and", "deletion", "mutations", "established", "that", "three", "open", "reading", "frames", "required", "for", "C1413756#ent", "<e1>", "desulfurization", ",", "and", "the", "C1417679#ent", "<e2>", "were", "designated", "soxABC", "(", "for", "sulfur", "oxidation", "."], "h": {"id": "C1413756", "name": "C1413756#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["These", "herbs", "induced", "the", "expression", "of", "C1334141#ent", "<e1>", ",", "pancreas", "duodenum", "homeobox-1", "(", "PDX-1", ")", ",", "and", "C0017713#ent", "<e2>", "."], "h": {"id": "C1334141", "name": "C1334141#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017713", "name": "C0017713#ent", "pos": [17, 18]}}
{"token": ["This", "was", "in", "contrast", "to", "C0043733#ent", "<e1>", "treatment", "which", "decreased", "the", "C1416867#ent", "<e2>", "content", "."], "h": {"id": "C0043733", "name": "C0043733#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "IVIg", "is", "a", "safe", "and", "effective", "therapy", "for", "patients", "with", "C4255078#ent", "<e1>", "and", "DM", "unresponsive", "to", "other", "C0991617#ent", "<e2>", "."], "h": {"id": "C4255078", "name": "C4255078#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [20, 21]}}
{"token": ["Serious", "arrhythmia", "documented", "in", "2", "patients", ",", "C0018790#ent", "<e1>", "1", "and", "complete", "C0151517#ent", "<e2>", "the", "other", "."], "h": {"id": "C0018790", "name": "C0018790#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0151517", "name": "C0151517#ent", "pos": [12, 13]}}
{"token": ["However", ",", "gastrin", "stimulated", "C1706586#ent", "<e1>", ",", "and", "activation", "of", "the", "C1415505#ent", "<e2>", "promoter", "was", "blocked", "by", "coexpression", "of", "a", "dominant", "negative", "Raf-1", "construct", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415505", "name": "C1415505#ent", "pos": [11, 12]}}
{"token": ["However", ",", "as", "the", "effects", "on", "protein", "phosphorylation", "induction", "of", "apoptosis", "differed", "between", "the", "mutant", "and", "C2987364#ent", "<e1>", "cell", "lines", "the", "mechanism", "of", "action", "of", "C0024027#ent", "<e2>", "may", "depend", "on", "partially", "different", "mechanisms", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0024027", "name": "C0024027#ent", "pos": [25, 26]}}
{"token": ["DNA", "immunization", "CD8(+", ")", "CTL", "responses", "by", "bone", "marrow-derived", "C1456795#ent", "<e1>", ",", "which", "are", "directly", "transfected", "with", "a", "plasmid", "DNA", "acquire", "C0796126#ent", "<e2>", "from", "DNA-transfected", "non-APCs", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [21, 22]}}
{"token": ["Collagen", "degradation", "C0162745#ent", "<e1>", "increased", "as", "much", "as", "3-fold", "after", "exposure", "to", "C0047301#ent", "<e2>", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0047301", "name": "C0047301#ent", "pos": [12, 13]}}
{"token": ["A", "representative", "compound", "(", "2a", ")", "demonstrated", "weak", "inhibiting", "properties", "towards", "human", "C0131373#ent", "<e1>", "and", "stimulated", "a", "C0033681#ent", "<e2>"], "h": {"id": "C0131373", "name": "C0131373#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [17, 18]}}
{"token": ["We", "measured", "levels", "of", "free", "and", "conjugated", "putrescine", "and", "spermidine", ",", "and", "C0002062#ent", "<e1>", "as", "well", "as", "activities", "of", "the", "putrescine-biosynthetic", "enzymes", "arginine", "C0029282#ent", "<e2>"], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [23, 24]}}
{"token": ["Treatment", "with", "C3541397#ent", "<e1>", "affected", "the", "dissolution", "behavior", "of", "C0700814#ent", "<e2>", "and", "especially", "Theo-Dur", "Sprinkle", "but", "had", "little", "or", "no", "effect", "the", "dissolution", "profiles", "of", "Theo-Dur", "tablets", "and", "Theo-24", "capsules", "."], "h": {"id": "C3541397", "name": "C3541397#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700814", "name": "C0700814#ent", "pos": [9, 10]}}
{"token": ["When", "present", "in", "molar", "excess", "over", "C1305923#ent", "<e1>", "trypsin", "inactivates", "rho", "C1706373#ent", "<e2>", "by", "a", "first", "order", "process", "that", "correlates", "well", "with", "the", "loss", "of", "intact", "rho", "polypeptide", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [11, 12]}}
{"token": ["The", "maximal", "amount", "of", "Ca2", "+", "bound", "to", "the", "high", "affinity", "sites", "corresponded", "to", "approximately", "1", "mol", "of", "calcium/mol", "of", "C1305923#ent", "<e1>", "both", "in", "purified", "ATPase", "vesicles", "in", "the", "soluble", "C1706373#ent", "<e2>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [30, 31]}}
{"token": ["Outer", "dynein", "arm", "C1305923#ent", "<e1>", "that", "possess", "Mg+2-adenosine", "triphosphatase", "(", "C1706373#ent", "<e2>", ")", "activity", "have", "been", "extracted", "from", "the", "flagellar", "axonemes", "demembranated", "bovine", "sperm", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [10, 11]}}
{"token": ["Other", "C0086376#ent", "<e1>", ",", "including", "RNA", "polymerase", "are", "also", "found", "to", "copurify", "with", "C0950779#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0950779", "name": "C0950779#ent", "pos": [13, 14]}}
{"token": ["The", "action", "of", "SER", "and", "5-HTL", "was", "predominantly", "C0003289#ent", "<e1>", "on", "the", "electrical", "activity", "C1706553#ent", "<e2>", "and", "5-MTL", "caused", "an", "excitation", "in", "most", "of", "the", "units", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706553", "name": "C1706553#ent", "pos": [14, 15]}}
{"token": ["In", "non-transplant", "patients", "with", "C2316401#ent", "<e1>", "proteinuria", ",", "inhibition", "of", "the", "renin-angiotensin", "system", "an", "C0003015#ent", "<e2>", "or", "an", "angiotensin", "receptor", "blocker", "been", "shown", "to", "delay", "the", "progression", "of", "renal", "disease"], "h": {"id": "C2316401", "name": "C2316401#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [14, 15]}}
{"token": ["Previous", "workers", "have", "reported", "that", "ethyl", "methylene", "blue", "C1539357#ent", "<e1>", ")", "diminishes", "cyanide-induced", "increases", "in", "C0795692#ent", "<e2>", "CIL", ")", ";", "the", "present", "study", "investigates", "the", "mechanism", "underlying", "this", "interaction", "."], "h": {"id": "C1539357", "name": "C1539357#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0795692", "name": "C0795692#ent", "pos": [15, 16]}}
{"token": ["As", "C1417679#ent", "<e1>", "associated", "with", "C0021053#ent", "<e2>", "an", "increased", "prior", "probability", "of", "being", "associated", "with", "C0021053#ent", "<e2>", "we", "tested", "three", "such", "C1417679#ent", "<e1>", ",", "IL23R", ",", "IRF5", "and", "CD40", ",", "for", "an", "association", "with", "type", "1", "diabetes"], "h": {"id": "C0021053", "name": "C0021053#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}}
{"token": ["The", "degree", "of", "activity", "generally", "correlated", "with", "binding", "affinity", "at", "sigma", "sites", "C0016368#ent", "<e1>", "=", "perphenazine", "=", "haloperidol", "=", "reduced", "haloperidol", ">", "C0031935#ent", "<e2>", "=", "spiperone", ">", ">", ">", ">"], "h": {"id": "C0016368", "name": "C0016368#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [22, 23]}}
{"token": ["The", "relative", "potency", "of", "the", "neuroleptics", "and", "structurally", "related", "compounds", "was", "calculated", "to", "be", "haloperidol", "greater", "than", "C0016368#ent", "<e1>", "greater", "than", "chlorpromazine", "greater", "than", "C0031935#ent", "<e2>", "than", "promazine", "."], "h": {"id": "C0016368", "name": "C0016368#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "pretreatment", "of", "C1704469#ent", "<e1>", "with", "anti-CD14", "MAb", "decreased", "binding", "of", "125I-labeled", "C0175697#ent", "<e2>", "to", "macrophages", ",", "suggesting", "that", "bovine", "mCD14", "serves", "as", "a", "receptor", "for", "C0175697#ent", "<e2>", "."], "h": {"id": "C1704469", "name": "C1704469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [14, 15]}}
{"token": ["C1704469#ent", "<e1>", ",", "in", "contrast", ",", "were", "stimulated", "by", "C0175697#ent", "<e2>", ",", "but", "not", "by", "C.", "neoformans", "to", "secrete", "MCP-1", "."], "h": {"id": "C1704469", "name": "C1704469#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [9, 10]}}
{"token": ["Intracellular", "C0001477#ent", "<e1>", "concentration", "increased", "in", "both", "Chinese", "hamster", "V79", "C0060197#ent", "<e2>", "extracellular", "Ca(2", "+", ")", "concentration", "increased", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0060197", "name": "C0060197#ent", "pos": [10, 11]}}
{"token": ["Although", "it", "was", "demonstrated", "that", "microsomes", "could", "bind", "large", "amounts", "of", "cholesterol", "in", "the", "absence", "of", "C1704896#ent", "<e1>", ",", "the", "bound", "cholesterol", "ineffective", "as", "a", "substrate", "for", "C0008380#ent", "<e2>"], "h": {"id": "C1704896", "name": "C1704896#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008380", "name": "C0008380#ent", "pos": [27, 28]}}
{"token": ["Whether", "C0030817#ent", "<e1>", "treatment", "was", "the", "sole", "cause", "of", "C0085655#ent", "<e2>", "or", "acted", "as", "a", "trigger", "for", "the", "development", "of", "a", "secondary", "autoimmune", "disease", "discussed", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085655", "name": "C0085655#ent", "pos": [9, 10]}}
{"token": ["Patients", "taking", "C0030817#ent", "<e1>", "who", "develop", "features", "suggestive", "of", "C0085655#ent", "<e2>", "may", "develop", "insidious", ",", "but", "potentially", "life-threatening", "cardiac", "involvement", "and", "must", "be", "carefully", "monitored", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085655", "name": "C0085655#ent", "pos": [9, 10]}}
{"token": ["Trihexyphenidyle", ",", "selegiline", ",", "C0165921#ent", "<e1>", ",", "apomorphine", "and", "C0023863#ent", "<e2>", "could", "be", "withdrawn", "shortly", "after", "starting", "STN", "electrical", "stimulation"], "h": {"id": "C0165921", "name": "C0165921#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023863", "name": "C0023863#ent", "pos": [9, 10]}}
{"token": ["C1421312#ent", "<e1>", "(Ucn)-I", "activation", "of", "CRFR2beta", "is", "C0007209#ent", "<e2>", "against", "ischemic", "reperfusion", "I/R", ")", "injury", "by", "stimulation", "of", "the", "ERKs1/2", "p42", ",", "44", "."], "h": {"id": "C1421312", "name": "C1421312#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [7, 8]}}
{"token": ["Staurosporine", "(", "protein", "kinase", "inhibitor", ",", "tamoxifen", "(", "estrogen", "antagonist", "protein", "kinase", "C", "inhibitor", ",", "forskolin", "(", "protein", "kinase", "A", "activator", ",", "R59949", "(", "C0113519#ent", "<e1>", ",", "curcumin", "and", "N-acetyl-L-cysteine", "(", "scavengers", "of", "reactive", "oxygen", "species", "and", "C3811061#ent", "<e2>", "acted", "as", "inhibitors", "."], "h": {"id": "C0113519", "name": "C0113519#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C3811061", "name": "C3811061#ent", "pos": [37, 38]}}
{"token": ["C1318533#ent", "<e1>", "caused", ",", "e.g.", ",", "by", "hemoglobin", "variants", "increased", "oxygen", "affinity", "by", "C0684324#ent", "<e2>", "or", "by", "mutations", "in", "the", "von", "Hippel-Lindau", "gene", "associated", "with", "disturbed", "oxygen-dependent", "regulation", "of", "Epo", "synthesis", "."], "h": {"id": "C1318533", "name": "C1318533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0684324", "name": "C0684324#ent", "pos": [13, 14]}}
{"token": ["The", "results", "suggest", "that", "testicular", "atrophy", "by", "C1413924#ent", "<e1>", "is", "associated", "with", "alteration", "in", "the", "activities", "of", "C3541394#ent", "<e2>", "related", "with", "specific", "events", "of", "spermatogenesis", "."], "h": {"id": "C1413924", "name": "C1413924#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["Reports", "of", "adverse", "reactions", "that", "significantly", "(", "P", "less", "than", "0.05", ")", "more", "patients", "complained", "of", "sedation", "in", "the", "C0008929#ent", "<e1>", "than", "in", "the", "C0065180#ent", "<e2>", "group", "."], "h": {"id": "C0008929", "name": "C0008929#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0065180", "name": "C0065180#ent", "pos": [24, 25]}}
{"token": ["The", "antihistamines", "and", "placebo", "were", "administered", "orally", "(", "C0008929#ent", "<e1>", "twice", "a", "day", ",", "C0065180#ent", "<e2>", "10", "mg", "once", "a", "day", ")", "for", "5", "days", "according", "to", "a", "double-blind", ",", "crossover", "design"], "h": {"id": "C0008929", "name": "C0008929#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0065180", "name": "C0065180#ent", "pos": [14, 15]}}
{"token": ["C1619629#ent", "<e1>", "is", "a", "new", "oral", "iron", "chelator", "to", "treat", "C0282193#ent", "<e2>"], "h": {"id": "C1619629", "name": "C1619629#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0282193", "name": "C0282193#ent", "pos": [10, 11]}}
{"token": ["The", "most", "common", "symptoms", "reported", "are", "fever", ",", "generalized", "lymphadenopathy", "arthralgia", "and", "myalgia", ",", "headache", ",", "C0031350#ent", "<e1>", ",", "enanthema", ",", "skin", "rash", "diarrhoea", ",", "and", "C0037299#ent", "<e2>"], "h": {"id": "C0031350", "name": "C0031350#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0037299", "name": "C0037299#ent", "pos": [26, 27]}}
{"token": ["Mutations", "in", "multiple", "cardiac", "sarcomeric", "proteins", "including", "myosin", "heavy", "chain", "MyHC", ")", "and", "cardiac", "troponin", "T", "C3538782#ent", "<e1>", ")", "cause", "a", "dominant", "genetic", "heart", "disease", "familial", "hypertrophic", "cardiomyopathy", "C1706242#ent", "<e2>", ")", "."], "h": {"id": "C3538782", "name": "C3538782#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706242", "name": "C1706242#ent", "pos": [28, 29]}}
{"token": ["This", "effect", "of", "C0162745#ent", "<e1>", "treatment", "on", "the", "insulin", "receptor", "due", "to", "C1413043#ent", "<e2>", "+", "-dependent", "heat-labile", "proteinases", "contaminating", "the", "preparation", "of", "C0162745#ent", "<e1>", ",", "and", "it", "could", "be", "mimicked", "by", "elastase", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [3, 4]}}
{"token": ["Na+", "and", "C1413043#ent", "<e1>", "+", "channel", "currents", "were", "present", "in", "myocytes", "isolated", "with", "C0162745#ent", "<e2>", "and", "elastase", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [13, 14]}}
{"token": ["Cross", "tolerance", "between", "C0064774#ent", "<e1>", "and", "a", "structurally", "related", "C0870507#ent", "<e2>", "bromocriptine", "."], "h": {"id": "C0064774", "name": "C0064774#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0870507", "name": "C0870507#ent", "pos": [9, 10]}}
{"token": ["FAH", "(", "C1414525#ent", "<e1>", "catalyses", "the", "final", "step", "of", "tyrosine", "catabolism", "produce", "C0220833#ent", "<e2>", "and", "acetoacetate", "."], "h": {"id": "C1414525", "name": "C1414525#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220833", "name": "C0220833#ent", "pos": [12, 13]}}
{"token": ["Fumarylacetoacetate", "hydrolase", "C1414525#ent", "<e1>", ")", "catalyzes", "the", "hydrolytic", "cleavage", "a", "carbon-carbon", "bond", "fumarylacetoacetate", "to", "yield", "C0220833#ent", "<e2>", "and", "acetoacetate", "as", "the", "final", "step", "of", "Phe", "and", "Tyr", "degradation", "."], "h": {"id": "C1414525", "name": "C1414525#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220833", "name": "C0220833#ent", "pos": [15, 16]}}
{"token": ["The", "different", "responses", "of", "C0014930#ent", "<e1>", "to", "the", "various", "combinations", "of", "phospho-modifications", "in", "C1414463#ent", "<e2>", "elucidate", "why", "certain", "C0014930#ent", "<e1>", "are", "more", "prone", "than", "others", "to", "develop", "resistance", "."], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014930", "name": "C0014930#ent", "pos": [4, 5]}}
{"token": ["Two-factor", "ANOVA", "of", "the", "phenotypes", "and", "genotypes", "of", "all", "673", "pcy/pcy", "mice", "from", "our", "cross", "indicated", "that", "C1704838#ent", "<e1>", "and", "MOP2", "alleles", "regulate", "C2987024#ent", "<e2>", "progression", "in", "a", "complex", "additive", "manner", "."], "h": {"id": "C1704838", "name": "C1704838#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2987024", "name": "C2987024#ent", "pos": [23, 24]}}
{"token": ["Celiac", "sprue", "also", "called", "C0007570#ent", "<e1>", "is", "a", "C0024523#ent", "<e2>", "symptoms", "that", "are", "triggered", "mainly", "by", "gluten", "ingestion", "."], "h": {"id": "C0007570", "name": "C0007570#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [8, 9]}}
{"token": ["No", "significant", "was", "noted", "in", "the", "activities", "of", "oxidative", "enzymes", "malate", "dehydrogenase", "C4085195#ent", "<e1>", ")", ",", "oxoglutarate", "dehydrogenase", "OGDH", ")", ",", "and", "C0000404#ent", "<e2>", "HADH", ")", "]", "."], "h": {"id": "C4085195", "name": "C4085195#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0000404", "name": "C0000404#ent", "pos": [22, 23]}}
{"token": ["The", "size-fractions", "were", "characterized", "by", "cross", "polarization", "CP", ")", "magic", "angle", "spinning", "(", "C0025048#ent", "<e1>", ")", "(13)C", "NMR", "spectroscopy", "a", "further", "analytical", "C1367469#ent", "<e2>", "elution", "under", "UV", "and", "fluorescence", "detection"], "h": {"id": "C0025048", "name": "C0025048#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [22, 23]}}
{"token": ["Macrophage", "activation", "syndrome", "C0025048#ent", "<e1>", ")", ",", "which", "can", "also", "be", "considered", "as", "reactive", "hemophagocytic", "syndrome", "C1367469#ent", "<e2>", ")", ",", "is", "a", "rare", "and", "potentially", "fatal", "complication", "of", "rheumatic", "diseases"], "h": {"id": "C0025048", "name": "C0025048#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [16, 17]}}
{"token": ["The", "qualitative", "composition", "of", "C0304106#ent", "<e1>", "and", "after", "the", "encapsulation", "process", "was", "determined", "by", "gas", "chromatography", "C3537453#ent", "<e2>", ")", "and", "gas", "chromatography/mass", "spectrum", "GC/MS", ")", "analyses", "."], "h": {"id": "C0304106", "name": "C0304106#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537453", "name": "C3537453#ent", "pos": [16, 17]}}
{"token": ["In", "the", "prechronic", "studies", ",", "increased", "C0027726#ent", "<e1>", "and", "mineralization", "at", "the", "kidney", "corticomedullary", "junction", "the", "primary", "toxic", "effects", "C0020261#ent", "<e2>", "observed", "in", "rats", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [19, 20]}}
{"token": ["C1274594#ent", "<e1>", "LPLK", ")", "is", "a", "common", "C0037284#ent", "<e2>", "has", "some", "morphologic", "features", "of", "lichen", "planus", "LP", ")", "and", "lichenoid", "actinic", "keratosis", "LAK", ")", "."], "h": {"id": "C1274594", "name": "C1274594#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [7, 8]}}
{"token": ["Many", "C1956003#ent", "<e1>", "as", "multisubunit", "and", "C0017363#ent", "<e2>", "which", "has", "made", "it", "difficult", "to", "assess", "their", "physiological", "functions", "traditional", "approaches"], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [6, 7]}}
{"token": ["The", "[14C]glucan-protein", ",", "precipitated", "by", "diluted", "trichloroacetic", "acid", "was", "digested", "by", "alpha-amylase", ",", "C0917783#ent", "<e1>", "a", ",", "and", "C0030940#ent", "<e2>", "."], "h": {"id": "C0917783", "name": "C0917783#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [18, 19]}}
{"token": ["Several", "bio-molecules", "such", "as", "proinflammatory", "cytokines", "components", "of", "signal", "transduction", "matrix", "degrading", "C0014442#ent", "<e1>", "resolve", "inflammatory", "responses", "might", "be", "new", "targets", "for", "treatment", "of", "C1290886#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1290886", "name": "C1290886#ent", "pos": [24, 25]}}
{"token": ["We", "previously", "reported", "the", "identification", "of", "the", "human", "CAP", "and", "CAP2", "C1417679#ent", "<e1>", "which", "encode", "proteins", "related", "to", "the", "C1382029#ent", "<e2>", "CAP", "protein"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [19, 20]}}
{"token": ["These", "observations", "indicate", "that", "FUS", "and", "C0808901#ent", "<e1>", "belong", "to", "the", "C1334046#ent", "<e2>"], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334046", "name": "C1334046#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "NR2A", "and", "NR2B", "subunits", "increase", "in", "the", "C1539614#ent", "<e1>", "was", "blocked", "by", "the", "injection", "of", "a", "C1332758#ent", "<e2>"], "h": {"id": "C1539614", "name": "C1539614#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332758", "name": "C1332758#ent", "pos": [18, 19]}}
{"token": ["C1336578#ent", "<e1>", "cardiomyopathy", ",", "skeletal", "myopathy", "neutropenia", "and", "C0342728#ent", "<e2>", "(", "3-mgc", ")", "aciduria", "."], "h": {"id": "C1336578", "name": "C1336578#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0342728", "name": "C0342728#ent", "pos": [8, 9]}}
{"token": ["These", "drugs", "include", "alinidine", ",", "C0208084#ent", "<e1>", ",", "cilobradine", ",", "ZD-7288", "and", "C0257190#ent", "<e2>", "."], "h": {"id": "C0208084", "name": "C0208084#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0257190", "name": "C0257190#ent", "pos": [12, 13]}}
{"token": ["C0236099#ent", "<e1>", "such", "as", "polycystic", "ovary", "syndrome", "PCOS", ")", ",", "C0002453#ent", "<e2>", "premature", "menopause", "and", "hyperprolactinemia", ",", "are", "reported", "to", "be", "more", "common", "in", "women", "with", "epilepsy", "than", "in", "the", "general", "female", "population", "."], "h": {"id": "C0236099", "name": "C0236099#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002453", "name": "C0002453#ent", "pos": [10, 11]}}
{"token": ["In", "patients", "with", "C0027059#ent", "<e1>", ",", "progression", "to", "residual", "C0018799#ent", "<e2>", "such", "as", "conduction", "disturbance", "or", "congestive", "heart", "failure", "is", "likely", "."], "h": {"id": "C0027059", "name": "C0027059#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [9, 10]}}
{"token": ["We", "screened", "biopsy", "specimens", "patients", "with", "C0027059#ent", "<e1>", "DCM", ",", "and", "myocardial", "tissues", "autopsy", "cases", "without", "C0018799#ent", "<e2>", "polymerase", "chain", "reaction", "PCR", ")", "gene", "amplification"], "h": {"id": "C0027059", "name": "C0027059#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "an", "C0162820#ent", "<e1>", "provoked", "after", "intradermal", "injection", "of", "C0034422#ent", "<e2>", "exposed", "to", "irradiation", "in", "vitro", "with", "serum", "taken", "from", "the", "patient", "."], "h": {"id": "C0162820", "name": "C0162820#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034422", "name": "C0034422#ent", "pos": [11, 12]}}
{"token": ["A", "potential", "selection", "index", "PSI", ")", ",", "the", "proposed", "or", "actual", "field", "use", "concentration", "of", "a", "C0013227#ent", "<e1>", "divided", "by", "its", "C1332110#ent", "<e2>", ",", "is", "defined", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332110", "name": "C1332110#ent", "pos": [21, 22]}}
{"token": ["Slow", "progression", "C0023890#ent", "<e1>", "occurs", ",", "with", "C0746495#ent", "<e2>", "pancreatitis", "as", "the", "major", "problems", "if", "the", "obstruction", "is", "in", "the", "larger", "duct", "system"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0746495", "name": "C0746495#ent", "pos": [7, 8]}}
{"token": ["The", "C0020498#ent", "<e1>", "studies", "revealed", "a", "decrease", "in", "mRNA", "expression", "of", "C1418457#ent", "<e2>", "and", "SP", "in", "the", "striatum", "and", "NAC", "."], "h": {"id": "C0020498", "name": "C0020498#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418457", "name": "C1418457#ent", "pos": [11, 12]}}
{"token": ["The", "phorbol", "ester", "12-O-tetradecanoylphorbol-13-acetate", "C0256103#ent", "<e1>", ")", "and", "the", "C0022022#ent", "<e2>", "ionomycin", "differentially", "regulated", "the", "expression", "of", "the", "gamma-T-cell", "antigen", "receptor", "gamma-TCR", ")", "gene", "in", "human", "thymocytes", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [9, 10]}}
{"token": ["The", "adipocytes", ",", "however", ",", "will", "extinguish", "differentiation-specific", "functions", "in", "response", "to", "C0256103#ent", "<e1>", "by", "the", "addition", "of", "a", "C0022022#ent", "<e2>"], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [19, 20]}}
{"token": ["Imino", "sugars", "used", "to", "treat", "type", "2", "diabetes", "mellitus", "miglitol", "(", "Glyset", ")", "]", "and", "lysosomal", "storage", "disorders", "C1321596#ent", "<e1>", "(", "Zavesca", ")", "]", "based", "on", "the", "inhibition", "of", "C0002272#ent", "<e2>", "and", "glucosyltransferases", "."], "h": {"id": "C1321596", "name": "C1321596#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [29, 30]}}
{"token": ["C1321596#ent", "<e1>", "and", "castanospermine", "(", "100", "micrograms/ml", ")", ",", "inhibitors", "of", "C0002272#ent", "<e2>", "in", "the", "endoplasmic", "reticulum", "ER", ")", ",", "prevented", "the", "increase", "in", "cellular", "LPL", "activity", "."], "h": {"id": "C1321596", "name": "C1321596#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [11, 12]}}
{"token": ["In", "the", "presence", "of", "C1321596#ent", "<e1>", "(", "an", "inhibitor", "of", "C0002272#ent", "<e2>", ")", "virions", "and", "the", "M", "protein", "surprisingly", "retained", "."], "h": {"id": "C1321596", "name": "C1321596#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [10, 11]}}
{"token": ["We", "have", "used", "a", "simple", "and", "efficient", "procedure", "for", "the", "synthesis", "of", "C1321596#ent", "<e1>", ",", "an", "affinity", "ligand", "for", "C0002272#ent", "<e2>", "Bernotas", ",", "R.", "C.", "and", "Ganem", ",", "B.", ",", "Biochem", "."], "h": {"id": "C1321596", "name": "C1321596#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [19, 20]}}
{"token": ["Although", "treatment", "with", "cyclophosphamide", "and", "prednisolone", "tended", "to", "reduce", "the", "level", "of", "proteinuria", ",", "the", "administration", "of", "angiotensin-converting", "enzyme", "inhibitor", "C0014027#ent", "<e1>", ",", "resulted", "in", "complete", "remission", "of", "C1704321#ent", "<e2>"], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [28, 29]}}
{"token": ["Thus", ",", "C0534519#ent", "<e1>", "inhibition", "may", "protect", "against", "LPS-induced", "C1705280#ent", "<e2>", "not", "only", "by", "preventing", "apoptotic", "cell", "death", "also", "by", "inhibiting", "inflammation", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [9, 10]}}
{"token": ["In", "order", "to", "allow", "differentiation", "between", "dermatological", "and", "C0027765#ent", "<e1>", "inherited", "or", "acquired", "peripheral", "neuropathies", "C0007682#ent", "<e2>", "Arnold-Chiari", "syndrome", "seizure-related", "disorders", "central", "nervous", "system", "tumours", "that", "may", "induce", "itch", "are", "discussed", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [15, 16]}}
{"token": ["In", "patients", "with", "C0027765#ent", "<e1>", "whom", "infectious", "C0007682#ent", "<e2>", "excluded", "TTP", "should", "be", "considered", "in", "the", "differential", "diagnosis"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [7, 8]}}
{"token": ["An", "C3273435#ent", "<e1>", "dominant-negative", "mutant", "blocked", "the", "distal", "accumulation", "of", "C1420364#ent", "<e2>", "and", "another", "known", "C3273435#ent", "<e1>", "binding", "protein", "Rho-GDI", "."], "h": {"id": "C1420364", "name": "C1420364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273435", "name": "C3273435#ent", "pos": [1, 2]}}
{"token": ["Our", "previous", "in-vitro", "study", "using", "C0001473#ent", "<e1>", "as", "a", "marker", "of", "P-gp", "activity", "suggested", "that", "C0073393#ent", "<e2>", "might", "be", "effectively", "transported", "by", "P-gp", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "the", "half-life", "of", "C0250391#ent", "<e1>", "is", "approximately", "1", "d.", "Major", "tissue", "depots", "included", "the", "C0023899#ent", "<e2>", ",", "adipose", "tissue", "and", "skin", "."], "h": {"id": "C0250391", "name": "C0250391#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["Wolf-Hirschhorn", "syndrome", "C1710644#ent", "<e1>", ")", "is", "caused", "by", "deletions", "involving", "C1956097#ent", "<e2>"], "h": {"id": "C1710644", "name": "C1710644#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C1956097", "name": "C1956097#ent", "pos": [10, 11]}}
{"token": ["Wolf-Hirschhorn", "syndrome", "C1710644#ent", "<e1>", ")", ",", "associated", "with", "deletion", "of", "C1956097#ent", "<e2>", "is", "characterized", "by", "mental", "and", "growth", "retardation", "typical", "facial", "dysmorphism"], "h": {"id": "C1710644", "name": "C1710644#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C1956097", "name": "C1956097#ent", "pos": [10, 11]}}
{"token": ["Two", "days", "after", "STZ", "administration", ",", "diabetic", "rats", "were", "treated", "for", "8", "weeks", "with", "C0014025#ent", "<e1>", "maleate", ",", "an", "ACE", "inhibitor", ",", "candesartan", "cilexetil", "an", "C0019592#ent", "<e2>", "or", "saline", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0019592", "name": "C0019592#ent", "pos": [25, 26]}}
{"token": ["Pharmacokinetic", "studies", "this", "C0013227#ent", "<e1>", "in", "mice", "indicate", "that", "C1434912#ent", "<e2>", "is", "orally", "bioavailable", "and", "rapidly", "distributed", "among", "various", "tissues", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1434912", "name": "C1434912#ent", "pos": [9, 10]}}
{"token": ["These", "effects", "associated", "with", "limited", "effect", "on", "analgesia", "may", "curtail", "the", "widespread", "use", "of", "C0009014#ent", "<e1>", "as", "an", "adjunct", "to", "extradural", "0.0625", "%", "bupivacaine", "with", "C0162792#ent", "<e2>", "10", "micrograms", "during", "labour", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0162792", "name": "C0162792#ent", "pos": [25, 26]}}
{"token": ["Compared", "with", "other", "drugs", ",", "C0009014#ent", "<e1>", "does", "not", "alter", "the", "dose", "of", "C0162792#ent", "<e2>", "inducing", "unconsciousness", "or", "EEG", "slowing", ",", "but", "it", "uniquely", "reduces", "isoflurane", "requirements", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162792", "name": "C0162792#ent", "pos": [13, 14]}}
{"token": ["C1420342#ent", "<e1>", "activated", "FAK", "and", "C0385469#ent", "<e2>", "in", "glioma", "cells", "characterized", "as", "responsive", "to", "C1420342#ent", "<e1>", "."], "h": {"id": "C0385469", "name": "C0385469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [0, 1]}}
{"token": ["Here", "we", "report", "molecular", "cloning", "a", "complete", "cDNA", "for", "the", "parasite", "'s", "intrinsic", "C1439270#ent", "<e1>", "and", "show", "it", "rescues", "an", "ALAD-null", "mutant", "of", "Escherichia", "coli", "indicating", "that", "the", "C0024530#ent", "<e2>", "a", "functional", "C1439270#ent", "<e1>", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1439270", "name": "C1439270#ent", "pos": [13, 14]}}
{"token": ["Nucleotide", "sequences", "the", "clones", "revealed", "that", "one", "clone", ",", "C3539540#ent", "<e1>", ",", "contained", "an", "open", "reading", "frame", "C0079941#ent", "<e2>", ")", "that", "would", "code", "for", "a", "26-amino", "acid", ",", "cysteine-rich", "peptide", "significant", "homology", "to", "Neurospora", "crassa", "copper", "metallothionein"], "h": {"id": "C3539540", "name": "C3539540#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [17, 18]}}
{"token": ["Nucleotide", "sequences", "the", "clones", "revealed", "that", "one", "clone", ",", "C3539540#ent", "<e1>", ",", "contained", "an", "C0079941#ent", "<e2>", "ORF", ")", "that", "would", "code", "for", "a", "26-amino", "acid", ",", "cysteine-rich", "peptide", "significant", "homology", "to", "Neurospora", "crassa", "copper", "metallothionein"], "h": {"id": "C3539540", "name": "C3539540#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [14, 15]}}
{"token": ["The", "majority", "of", "these", "mice", "displayed", "severe", "hypertrophy", "(", "heart-to-body", "weight", "ratios", ">", "2-fold", "greater", "in", "the", "C1419407#ent", "<e1>", "mice", ")", "and", "died", "from", "overt", "C0018801#ent", "<e2>", "days", "14", "and", "17", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [25, 26]}}
{"token": ["C0106497#ent", "<e1>", "was", "examined", "for", "the", "induction", "of", "C0017361#ent", "<e2>", "in", "adult", "Berlin", "K", "male", "Drosophila", "melanogaster", "either", "by", "feeding", "or", "by", "injection", "."], "h": {"id": "C0106497", "name": "C0106497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [8, 9]}}
{"token": ["Exposure", "to", "microM", "C0917834#ent", "<e1>", "for", "10", "min", "increased", "vascular", "smooth", "muscle", "immunoreactive", "C0085536#ent", "<e2>", "content", "of", "130", "-", "144-", ",", "86-", ",", "80-", ",", "75-", ",", "and", "58-kDa", "proteins", "."], "h": {"id": "C0917834", "name": "C0917834#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [13, 14]}}
{"token": ["Our", "previous", "studies", "revealed", "that", "C1367307#ent", "<e1>", ",", "a", "gp130", "downstream", "transcription", "factor", ",", "is", "required", "for", "AGM", "hematopoiesis", "and", "that", "homeodomain-interacting", "protein", "kinase", "2", "C1422622#ent", "<e2>", ")", "phosphorylates", "serine-727", "of", "C1367307#ent", "<e1>", "."], "h": {"id": "C1422622", "name": "C1422622#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [5, 6]}}
{"token": ["Aggressive", "prestudy", "hydration", "along", "with", "selective", "use", "of", "low", "osmolar", "contrast", "media", "significantly", "reduce", "the", "risk", "of", "C0022658#ent", "<e1>", "patients", "with", "either", "C1561643#ent", "<e2>", "diabetic", "nephropathy"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [22, 23]}}
{"token": ["Iron", ",", "which", "has", "been", "shown", "to", "accumulate", "within", "proximal", "tubule", "lysosomes", "in", "proteinuric", "models", "of", "C0022658#ent", "<e1>", "may", "play", "a", "role", "in", "the", "progression", "of", "C1561643#ent", "<e2>", "the", "generation", "of", "reactive", "oxygen", "species"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [26, 27]}}
{"token": ["On", "the", "contrary", ",", "in", "vitro", "NAC", "treatment", "at", "appropriate", "doses", "(", "10", "micrograms/ml", ")", "significantly", "enhanced", "C0003308#ent", "<e1>", "PBM", "from", "C0024117#ent", "<e2>", "patients", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [21, 22]}}
{"token": ["Significant", "clusters", "of", "activation", "were", "observed", "in", "left", "superior", "parietal", "lobe", "C3542429#ent", "<e1>", ")", "and", "the", "dorsal", "aspects", "of", "the", "inferior", "parietal", "cortex", "C1416867#ent", "<e2>", ")", "bordering", "the", "C3542429#ent", "<e1>", "."], "h": {"id": "C3542429", "name": "C3542429#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [23, 24]}}
{"token": ["The", "C0008035#ent", "<e1>", "not", "grow", "properly", "in", "children", "with", "spinal", "muscular", "atrophy", "C0026847#ent", "<e2>", ")", "with", "paradoxical", "breathing"], "h": {"id": "C0008035", "name": "C0008035#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [12, 13]}}
{"token": ["It", "was", "more", "sensitive", "in", "assaying", "adenovirus", "type", "3", "C0153064#ent", "<e1>", "vesicular", "stomatitis", "Semliki", "forest", "Sendai", ",", "Sindbis", ",", "and", "C0027983#ent", "<e2>", "were", "liquid", ",", "carboxymethylcellulose", ",", "and", "methylcellulose", "microculture", "plaque", "assays", "."], "h": {"id": "C0153064", "name": "C0153064#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027983", "name": "C0027983#ent", "pos": [20, 21]}}
{"token": ["Dexrazoxane", "reduces", "this", "cardiotoxicity", ",", "possibly", "by", "removal", "of", "C1166521#ent", "<e1>", "from", "doxorubicin", "by", "the", "EDTA-like", "hydrolysis", "product", "of", "C0086444#ent", "<e2>", ",", "ADR-925", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086444", "name": "C0086444#ent", "pos": [19, 20]}}
{"token": ["After", "C0021171#ent", "<e1>", "cocaine", ",", "preference", "developed", "for", "the", "drug", "side", "when", "the", "C0013227#ent", "<e2>", "was", "paired", "with", "the", "least", "preferred", "side", "."], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [13, 14]}}
{"token": ["Water-deprived", "animals", "were", "allowed", "15", "min", "access", "to", "0.1", "%", "sodium", "saccharin", "CS", ")", "followed", "10", "min", "later", "by", "C0021171#ent", "<e1>", "or", "by", "intracerebral", "injection", "of", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [27, 28]}}
{"token": ["When", "the", "dsRNAs", "were", "administered", "simultaneously", "with", "C0702208#ent", "<e1>", ",", "an", "inductor", "of", "the", "liver", "microsomal", "C3541394#ent", "<e2>", ",", "the", "dsRNAs", "eliminated", "its", "inducing", "effect", "."], "h": {"id": "C0702208", "name": "C0702208#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["alpha-Crystallin", "and", "C1333928#ent", "<e1>", "both", "efficiently", "suppressed", "the", "thermal", "aggregation", "C0007367#ent", "<e2>", "."], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [10, 11]}}
{"token": ["Reverse", "transcriptase-polymerase", "chain", "reaction", "sequencing", "analyses", "a", "C1868219#ent", "<e1>", "fusion", "transcript", "with", "FIP1L1", "intron", "10", "to", "C1335201#ent", "<e2>", "exon", "12", "and", "fluorescent", "in", "situ", "hybridization", "confirmed", "the", "interstitial", "deletion", "chromosome", "4q12"], "h": {"id": "C1868219", "name": "C1868219#ent", "pos": [7, 8]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335201", "name": "C1335201#ent", "pos": [16, 17]}}
{"token": ["Ribonuclease", "protection", "assay", "RPA", ")", "confirmed", "the", "induction", "of", "C1335207#ent", "<e1>", "and", "showed", "preferential", "expression", "of", "the", "C4288392#ent", "<e2>", "isoform", "over", "PLGF-2", "in", "MSCs", "and", "MG63", "cells", "."], "h": {"id": "C1335207", "name": "C1335207#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4288392", "name": "C4288392#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "large", "doses", "AREC", "on", "C1538430#ent", "<e1>", "were", "attenuated", "after", "co-administration", "of", "C0036442#ent", "<e2>", "(", "0.1", "mg/kg", ")", ",", "a", "muscarinic", "receptor", "antagonist"], "h": {"id": "C1538430", "name": "C1538430#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [14, 15]}}
{"token": ["A", "major", "difference", "between", "the", "two", "C3540790#ent", "<e1>", "is", "the", "molecular", "masses", "C0054757#ent", "<e2>", "is", "50,000", "-", "56,000", ",", "whereas", "CPD", "is", "approximately", "180,000", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054757", "name": "C0054757#ent", "pos": [12, 13]}}
{"token": ["Several", "of", "the", "genes", "for", "C3540790#ent", "<e1>", "involved", "in", "peptide", "hormone", "processing", ",", "such", "as", "carboxypeptidase", "E", "C0054757#ent", "<e2>", ")", ",", "do", "not", "contain", "a", "TATA", "box"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0054757", "name": "C0054757#ent", "pos": [17, 18]}}
{"token": ["The", "antiepileptic", "drugs", "phenobarbital", ",", "phenytoin", "and", "C0006949#ent", "<e1>", "are", "widely", "used", "for", "the", "treatment", "of", "partial", "and", "C0014549#ent", "<e2>"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [18, 19]}}
{"token": ["Systemic", "C0025942#ent", "<e1>", "seems", "to", "be", "the", "C0013227#ent", "<e2>", "of", "choice", "in", "the", "treatment", "of", "systemic", "chronic", "mucocutaneous", "candidiasis"], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}}
{"token": ["C0015544#ent", "<e1>", "malnutrition", "are", "common", "clinical", "features", "in", "C0010674#ent", "<e2>", "CF", ")", ",", "but", "the", "relationships", "among", "resting", "energy", "expenditure", "REE", ")", ",", "pulmonary", "function", "and", "nutritional", "status", "are", "poorly", "understood", "."], "h": {"id": "C0015544", "name": "C0015544#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "suggest", "that", "the", "human", "G147D", "PPI-1", "can", "attenuate", "responses", "of", "cardiomyocytes", "to", "beta-adrenergic", "agonists", "decreasing", "C1418650#ent", "<e1>", "phosphorylation", "and", "therefore", "may", "contribute", "to", "deteriorated", "function", "in", "C0018802#ent", "<e2>"], "h": {"id": "C1418650", "name": "C1418650#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [28, 29]}}
{"token": ["Not", "all", "of", "the", "6", "classical", "lesions", "(", "hemangioblastoma", "of", "the", "CNS", ",", "C0019562#ent", "<e1>", "pancreatic", "cysts", "renal", "cysts", "carcinoma", ",", "pheochromocytoma", "and", "C0037859#ent", "<e2>", "are", "present", "in", "VHL", "families", "."], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [13, 14]}, "relation": "has_manifestation", "t": {"id": "C0037859", "name": "C0037859#ent", "pos": [23, 24]}}
{"token": ["Common", "manifestations", "of", "the", "von", "Hippel-Lindau", "syndrome", "an", "autosomally", "dominant", "cancer-prone", "disorder", ",", "include", "C0019562#ent", "<e1>", "hemangioblastoma", "of", "the", "central", "nervous", "system", "renal", "cysts", "renal", "cancer", "pheochromocytoma", ",", "and", "C0037859#ent", "<e2>"], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0037859", "name": "C0037859#ent", "pos": [29, 30]}}
{"token": ["Limb", "bud", "mesenchymal", "cells", "Dlx5/6(-/-", ")", "embryos", "show", "reduced", "chondrogenesis", "compared", "to", "C2987364#ent", "<e1>", "littermates", ",", "and", "expression", "of", "either", "C1414079#ent", "<e2>", "or", "Dlx6", "stimulated", "differentiation", "of", "limb", "bud", "mesenchymal", "cells", "chondroblasts", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414079", "name": "C1414079#ent", "pos": [20, 21]}}
{"token": ["Bifonazole", "(", "Bay", "h", "4502", ",", "C0129435#ent", "<e1>", ")", "and", "clotrimazole", "(", "C0701174#ent", "<e2>", "Canesten", ")", "are", "potent", "inhibitors", "of", "ergosterol", "synthesis", "yeasts", "and", "dermatophytes", "."], "h": {"id": "C0129435", "name": "C0129435#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0701174", "name": "C0701174#ent", "pos": [12, 13]}}
{"token": ["This", "work", "reviewed", "all", "the", "reports", "on", "the", "C1705026#ent", "<e1>", "schizophrenia", ",", "which", "have", "been", "published", "since", "the", "C0079429#ent", "<e2>", "was", "found", "to", "be", "associated", "with", "illness", "among", "a", "British", "population", "2000", "."], "h": {"id": "C1705026", "name": "C1705026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}}
{"token": ["Taken", "together", ",", "the", "C1705026#ent", "<e1>", "be", "associated", "with", "schizophrenia", "but", "how", "the", "C0079429#ent", "<e2>", "contributes", "to", "the", "etiology", "of", "the", "illness", "needs", "a", "further", "investigation", "."], "h": {"id": "C1705026", "name": "C1705026#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["C0051618#ent", "<e1>", "from", "Aspergillus", "oryzae", "adsorbed", "on", "functionallized", "macroporous", "copolymers", "where", "the", "C0014442#ent", "<e2>", "showed", "excellent", "catalyzing", "activity", "and", "operation", "stability", "."], "h": {"id": "C0051618", "name": "C0051618#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["Subcellular", "fractionation", "pig", "kidney", "cortex", "that", "C0051618#ent", "<e1>", "EC", "3.5.1.14", ",", "N-acyl-L-amino-acid", "aminohydrolase", "is", "predominantly", "a", "soluble", "C0014442#ent", "<e2>", "with", "only", "0.5", "%", "of", "the", "total", "activity", "being", "recovered", "in", "the", "membrane", "fraction"], "h": {"id": "C0051618", "name": "C0051618#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "C0251991#ent", "<e1>", "may", "represent", "a", "novel", "structure", "from", "which", "future", "C3494348#ent", "<e2>", "be", "developed", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [12, 13]}}
{"token": ["The", "term", "'", "neck", "problem", "'", ",", "however", ",", "encompasses", "a", "whole", "range", "of", "conditions", ",", "including", "soft", "tissue", "disorders", "C0038019#ent", "<e1>", "prolapsed", "intervertebral", "disk", "and", "severe", "C0038013#ent", "<e2>", "cervical", "instability"], "h": {"id": "C0038019", "name": "C0038019#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [27, 28]}}
{"token": ["Fractures", "ensued", "two", "times", "in", "patients", "with", "heavy", "spondylarthrosis", "C0038019#ent", "<e1>", ",", "once", "in", "C0038013#ent", "<e2>", "once", "in", "intact", "spine", "."], "h": {"id": "C0038019", "name": "C0038019#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [14, 15]}}
{"token": ["We", "review", "the", "usefulness", "of", "skin", "biopsy", "cerebral", "autosomal", "dominant", "arteriopathy", "with", "subcortical", "infarcts", "C0270612#ent", "<e1>", "(", "CADASIL", ")", ",", "some", "C0085078#ent", "<e2>", "Lafora", "disease", "in", "peripheral", "neuropathies"], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [21, 22]}}
{"token": ["Adult", "C0270612#ent", "<e1>", "caused", "by", "alpha-mannosidosis", "deficiency", "MIM248500", ")", "is", "a", "recessive", "inherited", "C0085078#ent", "<e2>", "associated", "with", "decreased", "activity", "of", "alpha-mannosidase", "."], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [13, 14]}}
{"token": ["Then", ",", "the", "relationship", "between", "C1417407#ent", "<e1>", "expression", "and", "sensitivity", "to", "the", "inhibitors", "of", "de", "novo", "C4084937#ent", "<e2>", "synthesis", "was", "confirmed", "in", "an", "MTAP-negative", "and", "-positive", "osteosarcoma", "cell", "line"], "h": {"id": "C1417407", "name": "C1417407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4084937", "name": "C4084937#ent", "pos": [16, 17]}}
{"token": ["Genetic", "studies", "Drosophila", "have", "identified", "double-time", "(", "dbt", ")", ",", "a", "C1413288#ent", "<e1>", "is", "highly", "homologous", "to", "human", "C0752519#ent", "<e2>", "CKIepsilon", ")", ",", "as", "the", "first", "kinase", "linked", "to", "behavioral", "rhythms", "."], "h": {"id": "C1413288", "name": "C1413288#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0752519", "name": "C0752519#ent", "pos": [18, 19]}}
{"token": ["To", "date", ",", "three", "loci", "have", "been", "linked", "to", "this", "syndrome", ",", "and", "recently", ",", "the", "gene", "encoding", "ataxia-telangiectasia", "and", "C3711837#ent", "<e1>", "ATR", ")", "was", "identified", "as", "the", "gene", "mutated", "the", "C1332120#ent", "<e2>"], "h": {"id": "C3711837", "name": "C3711837#ent", "pos": [20, 21]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332120", "name": "C1332120#ent", "pos": [31, 32]}}
{"token": ["The", "human", "C3711837#ent", "<e1>", "its", "homolog", "in", "yeast", ",", "C1332120#ent", "<e2>", ",", "play", "central", "roles", "in", "transducing", "the", "damage", "signal", "."], "h": {"id": "C3711837", "name": "C3711837#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332120", "name": "C1332120#ent", "pos": [9, 10]}}
{"token": ["The", "interactions", "of", "artemisinin", "with", "atovaquone", ",", "quinine", ",", "and", "C0025153#ent", "<e1>", "were", "investigated", "in", "three", "C0024535#ent", "<e2>", "strains", "F-32", ",", "FCR-3", ",", "and", "K-1", ")", "by", "an", "in", "vitro", "culture", "assay"], "h": {"id": "C0025153", "name": "C0025153#ent", "pos": [10, 11]}, "relation": "may_prevent", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [16, 17]}}
{"token": ["Resistance", "of", "P.", "falciparum", "C0025153#ent", "<e1>", "emerged", "along", "the", "Thai-Cambodian", "border", "following", "the", "C0024535#ent", "<e2>", "malaria", "outbreak", "in", "Bo", "Rai", "areas", "in", "late", "1988", "."], "h": {"id": "C0025153", "name": "C0025153#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [13, 14]}}
{"token": ["C0025153#ent", "<e1>", "is", "the", "main", "antimalarial", "used", "for", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "patients", "at", "the", "malaria", "clinics", "in", "Thailand", "."], "h": {"id": "C0025153", "name": "C0025153#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [10, 11]}}
{"token": ["The", "K(m", ")", "values", "for", "L-xylulose", "and", "C0043369#ent", "<e1>", "were", "similar", "to", "those", "reported", "for", "C1425932#ent", "<e2>", "EC", "1.1.1.10", ")", "of", "guinea", "pig", "liver", "."], "h": {"id": "C0043369", "name": "C0043369#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1425932", "name": "C1425932#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", "the", "C0003195#ent", "<e1>", "and", "the", "proarrhythmic", "activities", "of", "C0167716#ent", "<e2>", ",", "a", "selective", "class", "III", "antiarrhythmic", "agent", ",", "were", "compared", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0167716", "name": "C0167716#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "we", "demonstrate", "that", "all", "three", "C1366503#ent", "<e1>", "transcripts", "are", "induced", "by", "C0022265#ent", "<e2>", "MCF7", "cells"], "h": {"id": "C1366503", "name": "C1366503#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [13, 14]}}
{"token": ["Currently", ",", "a", "C0018440#ent", "<e1>", "triple", "therapy", "containing", "clarithromycin", ",", "amoxicillin", "or", "C3536882#ent", "<e2>", "for", "7", "days", "is", "the", "recommended", "first-line", "treatment", "approach", "an", "expected", "eradication", "success", "rate", "of", "approximately", "80", "%", "."], "h": {"id": "C0018440", "name": "C0018440#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536882", "name": "C3536882#ent", "pos": [12, 13]}}
{"token": ["No", "correlation", "of", "C1705280#ent", "<e1>", "expression", "with", "clinical", "stage", "C1704824#ent", "<e2>", "Rb", "expression", "or", "Rb", "phosphorylation", "was", "found", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704824", "name": "C1704824#ent", "pos": [9, 10]}}
{"token": ["In", "serous", "carcinoma", "p53", "mutation", "the", "most", "frequent", "genetic", "alteration", "followed", "by", "inactivation", "of", "C1705280#ent", "<e1>", "and", "e-cadherin", "and", "amplification", "of", "C1704824#ent", "<e2>", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1704824", "name": "C1704824#ent", "pos": [21, 22]}}
{"token": ["Compared", "to", "C1161331#ent", "<e1>", ",", "a", "200", "%", "increase", "in", "C0052430#ent", "<e2>", "by", "glucose", "was", "observed", "."], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0052430", "name": "C0052430#ent", "pos": [10, 11]}}
{"token": ["Combined", "genotypes", "with", "at", "least", "one", "variant", "C1706112#ent", "<e1>", "in", "XPD", "or", "C1366475#ent", "<e2>", "were", "significantly", "associated", "with", "cancer-specific", "survival", "compared", "with", "remaining", "groups", "(", "P=0.009", ")", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366475", "name": "C1366475#ent", "pos": [12, 13]}}
{"token": ["These", "data", "are", "consistent", "with", "C1537630#ent", "<e1>", "being", "the", "gene", "for", "the", "human", "C0007965#ent", "<e2>", "strengthen", "the", "synteny", "relationship", "between", "MMU13", "and", "human", "1q43", "."], "h": {"id": "C1537630", "name": "C1537630#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0007965", "name": "C0007965#ent", "pos": [13, 14]}}
{"token": ["The", "enzyme", "isolated", "from", "bone", "exhibited", "a", "lower", "K(m", ")", "for", "C0134796#ent", "<e1>", "was", "slightly", "more", "sensitive", "to", "C1423108#ent", "<e2>", "inhibitors", "such", "as", "molybdate", ",", "tungstate", ",", "arsenate", "and", "phosphate", "."], "h": {"id": "C0134796", "name": "C0134796#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [18, 19]}}
{"token": ["Anti-P1", "activity", "was", "detected", "in", "61", "%", "of", "the", "C0029106#ent", "<e1>", "sera", ",", "57", "%", "of", "the", "C0009021#ent", "<e2>", "sera", "and", "in", "26.6", "%", "of", "the", "control", "subjects"], "h": {"id": "C0029106", "name": "C0029106#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009021", "name": "C0009021#ent", "pos": [17, 18]}}
{"token": ["It", "included", "5,446", "patients", "who", "had", "C0155583#ent", "<e1>", "HBP", ")", "and", "1,014", "patients", "who", "had", "isolated", "systolic", "hypertension", "C0020498#ent", "<e2>", ")", "."], "h": {"id": "C0155583", "name": "C0155583#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020498", "name": "C0020498#ent", "pos": [18, 19]}}
{"token": ["In", "an", "examination", "of", "the", "cytoplasmic", "fraction", "HeLa", "cells", "more", "than", "1000", "phosphopeptides", "were", "identified", "using", "C3844603#ent", "<e1>", "acid-modified", "titania", "MOC", "and", "C2608095#ent", "<e2>", "acid-modified", "zirconia", "MOC", ",", "respectively", "."], "h": {"id": "C3844603", "name": "C3844603#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2608095", "name": "C2608095#ent", "pos": [22, 23]}}
{"token": ["We", "present", "the", "case", "of", "a", "23-yr-old", "man", "who", "had", "had", "since", "birth", "marked", "sustained", "unconjugated", "C0020433#ent", "<e1>", "who", "had", "had", "several", "attacks", "of", "C0036572#ent", "<e2>"], "h": {"id": "C0020433", "name": "C0020433#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [24, 25]}}
{"token": ["Gastric", "carcinoma", "occur", "sporadically", "or", "in", "association", "with", "C0015398#ent", "<e1>", "such", "as", "C0031269#ent", "<e2>", "PJS", ")", "."], "h": {"id": "C0015398", "name": "C0015398#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031269", "name": "C0031269#ent", "pos": [12, 13]}}
{"token": ["Gastric", "carcinoma", "occur", "sporadically", "or", "in", "association", "with", "C0015398#ent", "<e1>", "such", "as", "Peutz-Jehgers", "syndrome", "C0031269#ent", "<e2>", ")", "."], "h": {"id": "C0015398", "name": "C0015398#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031269", "name": "C0031269#ent", "pos": [14, 15]}}
{"token": ["Nausea", "and", "dispepsy", "are", "present", "in", "60", "percent", ",", "and", "C0341177#ent", "<e1>", "50", "percent", "of", "patients", "on", "regular", "C0003211#ent", "<e2>", "treatment", "."], "h": {"id": "C0341177", "name": "C0341177#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [18, 19]}}
{"token": ["C3810600#ent", "<e1>", "is", "involved", "in", "the", "interaction", "of", "C1420197#ent", "<e2>", "and", "the", "vacuolar", "proton", "pump"], "h": {"id": "C3810600", "name": "C3810600#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420197", "name": "C1420197#ent", "pos": [8, 9]}}
{"token": ["Previous", "studies", "have", "suggested", "a", "conformational", "change", "C3714798#ent", "<e1>", "upon", "binding", "of", "C4078840#ent", "<e2>", "CPR", ")", "or", "cytochrome", "b(5", ")", "(", "b(5", ")", ")", "."], "h": {"id": "C3714798", "name": "C3714798#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4078840", "name": "C4078840#ent", "pos": [12, 13]}}
{"token": ["These", "mechanisms", "were", "reinvestigated", "for", "human", "C3714798#ent", "<e1>", "bound", "to", "recombinant", "yeast", "membranes", "human", "C4078840#ent", "<e2>", "various", "levels", "of", "human", "b5", "."], "h": {"id": "C3714798", "name": "C3714798#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4078840", "name": "C4078840#ent", "pos": [14, 15]}}
{"token": ["It", "is", "also", "shown", "that", "the", "efficiency", "of", "S-glutathionylation", "of", "either", "native", "or", "C1414968#ent", "<e1>", "enhanced", "by", "the", "presence", "of", "recombinant", "glutaredoxin", "(", "C1870389#ent", "<e2>", "of", "either", "bacterial", "or", "human", "origin", "."], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1870389", "name": "C1870389#ent", "pos": [23, 24]}}
{"token": ["Endogenous", "expression", "and", "the", "activities", "of", "C1565919#ent", "<e1>", "and", "PKC-lambda/zeta", ",", "but", "not", "of", "C3272754#ent", "<e2>", ",", "were", "detected", "in", "3T3-L1", "adipocytes", "."], "h": {"id": "C1565919", "name": "C1565919#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3272754", "name": "C3272754#ent", "pos": [14, 15]}}
{"token": ["Treatment", "C0030135#ent", "<e1>", "decreases", "the(18)O", "incorporation", "into", "C4048300#ent", "<e2>", "."], "h": {"id": "C0030135", "name": "C0030135#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4048300", "name": "C4048300#ent", "pos": [7, 8]}}
{"token": ["Skin", "diseases", "the", "udder", "include", "C0162628#ent", "<e1>", "mange", ",", "sunburn", ",", "wounds", ",", "and", "C0038157#ent", "<e2>"], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038157", "name": "C0038157#ent", "pos": [14, 15]}}
{"token": ["Pharmacologic", "management", "C0017168#ent", "<e1>", "includes", "a", "prokinetic", "agent", "as", "metoclopramide", "or", "C0072916#ent", "<e2>", "and", "a", "histamine-receptor", "type", "2", "antagonist", "as", "cimetidine", "or", "ranitidine", "when", "esophagitis", "is", "suspected", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [11, 12]}}
{"token": ["Cisapride", "did", "not", "significantly", "alter", "C0017168#ent", "<e1>", "gall", "bladder", "motility", "altered", "after", "C0072916#ent", "<e2>", "treatment", "(", "p", "<", "0.05", ")", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [12, 13]}}
{"token": ["a", "C1705783#ent", "<e1>", "release", "inhibitor", ",", "attenuated", "diabetes", "and", "C2699123#ent", "<e2>", "induced", "decrease", "in", "nociceptive", "threshold", "and", "increase", "in", "serum", "nitrite", "oxide", "levels", "."], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2699123", "name": "C2699123#ent", "pos": [9, 10]}}
{"token": ["This", "previously", "unidentified", "C0030946#ent", "<e1>", "may", "be", "an", "important", "protective", "antigen", "vaccines", "designed", "to", "prevent", "C0030636#ent", "<e2>", "from", "P.", "trehalosi", "in", "bighorn", "sheep"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030636", "name": "C0030636#ent", "pos": [15, 16]}}
{"token": ["We", "found", "cyclin-dependent", "kinase", "5", "C1332735#ent", "<e1>", ")", "immunoreactivity", "in", "most", "of", "C1420713#ent", "<e2>", "in", "an", "ALS", "patient", "."], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420713", "name": "C1420713#ent", "pos": [12, 13]}}
{"token": ["The", "location", "of", "C3540772#ent", "<e1>", "in", "the", "cases", "of", "C0156221#ent", "<e2>", "was", "the", "same", "as", "that", "in", "normal", "kidneys", "and", "we", "were", "unable", "to", "demonstrate", "any", "de", "novo", "expression", "of", "GST", "isoenzymes", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [9, 10]}}
{"token": ["We", "aimed", "to", "compare", "the", "effectiveness", "of", "early", "use", "of", "combined", "immunosuppression", "with", "conventional", "management", "patients", "with", "C0010346#ent", "<e1>", "had", "not", "previously", "received", "glucocorticoids", ",", "C0003376#ent", "<e2>", ",", "or", "infliximab", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003376", "name": "C0003376#ent", "pos": [25, 26]}}
{"token": ["45", "(", "1989", ")", "891", "]", "proposed", "that", "C0009262#ent", "<e1>", "(", "EIN", ")", "acts", "as", "an", "antioxidant", "and", "C0033613#ent", "<e2>", "lipid", "peroxidation", "a", "rat", "model", "of", "liver", "injury"], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033613", "name": "C0033613#ent", "pos": [18, 19]}}
{"token": ["A", "HPLC", "method", "has", "been", "developed", "which", "permits", "the", "quantification", "of", "methyl", "paraben", "benzethonium", "chloride", "C0040958#ent", "<e1>", "in", "various", "samples", "of", "grapefruit", "seed", "extract", "C1332802#ent", "<e2>", ")", "."], "h": {"id": "C0040958", "name": "C0040958#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332802", "name": "C1332802#ent", "pos": [24, 25]}}
{"token": ["Postmortem", "drug", "redistribution", "suicidal", "poisonings", "C1384520#ent", "<e1>", "(", "dextropropoxyphene", "and", "C0000970#ent", "<e2>", ")", "has", "been", "studied", "."], "h": {"id": "C1384520", "name": "C1384520#ent", "pos": [5, 6]}, "relation": "has_constitutional_part", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [10, 11]}}
{"token": ["These", "results", "may", "contribute", "to", "the", "understanding", "of", "the", "abnormalities", "of", "T-B", "interactions", "and", "the", "C0221406#ent", "<e1>", "of", "antibody", "in", "C0024141#ent", "<e2>", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [20, 21]}}
{"token": ["The", "resulting", "decrease", "in", "C2744579#ent", "<e1>", "inhibits", "reduction", "of", "3-phosphoglycerate", "to", "C0041078#ent", "<e2>", "mass", "action", "on", "3-phosphoglycerate", "kinase"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041078", "name": "C0041078#ent", "pos": [11, 12]}}
{"token": ["Glutamate-cysteine", "ligase", "C1522376#ent", "<e1>", ")", "and", "glutathione", "synthetase", "GS", ")", "are", "the", "two", "unrelated", "C0009227#ent", "<e2>", "that", "constitute", "the", "glutathione", "biosynthesis", "pathway", "most", "eukaryotes", ",", "purple", "bacteria", "and", "cyanobacteria", "."], "h": {"id": "C1522376", "name": "C1522376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009227", "name": "C0009227#ent", "pos": [14, 15]}}
{"token": ["Plants", "and", "plant", "products", "lead", "to", "a", "variety", "of", "C0037274#ent", "<e1>", "commonly", "referred", "to", "as", "C0040247#ent", "<e2>", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [15, 16]}}
{"token": ["These", "cases", "of", "C0037274#ent", "<e1>", "were", "composed", "of", "the", "following", ":", "C0040247#ent", "<e2>", "10,656", ",", "candidiasis", "3,287", ",", "malassezia", "infection", ",", "sporothrichosis", "20", ",", "aspergillosis", "7", ",", "and", "chromomycosis", "1"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [11, 12]}}
{"token": ["MAP", "kinase", "phosphatase", "5", "C1414181#ent", "<e1>", ")", "is", "a", "member", "of", "the", "mitogen-activated", "protein", "kinase", "phosphatase", "C0387658#ent", "<e2>", ")", "family", "and", "selectively", "dephosphorylates", "JNK", "and", "p38", "."], "h": {"id": "C1414181", "name": "C1414181#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0387658", "name": "C0387658#ent", "pos": [16, 17]}}
{"token": ["The", "C677", "T", "polymorphism", "in", "5',10'-methylenetetrahydrofolate", "reductase", "C0919427#ent", "<e1>", ")", "gene", "may", "modulate", "the", "risk", "of", "C0030286#ent", "<e2>"], "h": {"id": "C0919427", "name": "C0919427#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030286", "name": "C0030286#ent", "pos": [16, 17]}}
{"token": ["The", "C677", "T", "polymorphism", "in", "C0919427#ent", "<e1>", "MTHFR", ")", "gene", "may", "modulate", "the", "risk", "of", "C0030286#ent", "<e2>"], "h": {"id": "C0919427", "name": "C0919427#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030286", "name": "C0030286#ent", "pos": [15, 16]}}
{"token": ["We", "showed", "that", "C1418985#ent", "<e1>", "is", "induced", "by", "activating", "transcription", "factor", "4", "ATF4", ")", ",", "regulated", "by", "C1426334#ent", "<e2>", "eukaryotic", "initiation", "factor", "2alpha", "(", "eIF2alpha", ")", "kinase", "."], "h": {"id": "C1418985", "name": "C1418985#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1426334", "name": "C1426334#ent", "pos": [17, 18]}}
{"token": ["With", "the", "use", "of", "chimeric", "receptors", "the", "C1334083#ent", "<e1>", "IFN-gammaR", ")", "complex", "as", "a", "model", "system", "we", "demonstrate", "that", "C1334291#ent", "<e2>", "activation", "is", "not", "an", "absolute", "requirement", "for", "IFN-gamma", "signaling", "."], "h": {"id": "C1334083", "name": "C1334083#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334291", "name": "C1334291#ent", "pos": [19, 20]}}
{"token": ["In", "humans", ",", "deficiency", "of", "galactose-1-phosphate", "uridyltransferase", "C1414962#ent", "<e1>", ")", "can", "lead", "a", "C0025517#ent", "<e2>", "Classic", "Galactosemia"], "h": {"id": "C1414962", "name": "C1414962#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [13, 14]}}
{"token": ["6", "The", "positive", "inotropic", "effect", "C0700541#ent", "<e1>", "was", "inhibited", "by", "C0280858#ent", "<e2>", "(", "10", "-", "6", "M", ")", "and", "by", "caffeine", "(", "4", "X10", "-", "3", "M", ")", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [10, 11]}}
{"token": ["The", "positive", "chronotropic", "action", "of", "C0700541#ent", "<e1>", "is", "not", "reversed", "by", "C0280858#ent", "<e2>", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [11, 12]}}
{"token": ["This", "study", "suggests", "that", "C1420817#ent", "<e1>", "may", "be", "a", "useful", "C0013227#ent", "<e2>", "in", "the", "treatment", "of", "generalized", "epilepsies", "children", "."], "h": {"id": "C1420817", "name": "C1420817#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["A", "combination", "of", "VPA", "and", "C1420817#ent", "<e1>", "can", "be", "used", "if", "either", "C0013227#ent", "<e2>", "alone", "is", "unsuccessful", "."], "h": {"id": "C1420817", "name": "C1420817#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "investigate", "the", "cause", "of", "recurrent", "monolateral", "incomplete", "C0035328#ent", "<e1>", "a", "44-year-old", "woman", "and", "the", "association", "between", "retinal", "vein", "occlusion", "C0380964#ent", "<e2>"], "h": {"id": "C0035328", "name": "C0035328#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0380964", "name": "C0380964#ent", "pos": [26, 27]}}
{"token": ["While", "not", "preventing", "this", "destruction", "of", "heat-injured", "epithelium", "by", "C0076942#ent", "<e1>", ",", "simultaneous", "use", "of", "C0358151#ent", "<e2>", "reduce", "the", "weight", "loss", "purulence", "associated", "with", "therapy", "of", "burns", "."], "h": {"id": "C0076942", "name": "C0076942#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0358151", "name": "C0358151#ent", "pos": [15, 16]}}
{"token": ["C0028362#ent", "<e1>", "is", "an", "indirect", "C0243192#ent", "<e2>", "of", "5-hydroxytryptamine", "(", "5-HT", ")", "receptors", "that", "acts", "by", "evoking", "5-HT", "release", "and", "blocking", "5-HT", "reuptake", "neuronal", "cells"], "h": {"id": "C0028362", "name": "C0028362#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [5, 6]}}
{"token": ["We", "suspect", "total", "C1453171#ent", "<e1>", "dysfunction", "to", "be", "a", "major", "modifier", "of", "CF", "C0024115#ent", "<e2>"], "h": {"id": "C1453171", "name": "C1453171#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [13, 14]}}
{"token": ["C0038013#ent", "<e1>", "affects", "the", "forefoot", ",", "causing", "C0311337#ent", "<e2>", ",", "hallux", "valgus", "and", "deformities", "of", "the", "lesser", "toes"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0311337", "name": "C0311337#ent", "pos": [7, 8]}}
{"token": ["Here", "we", "demonstrate", "that", "TPL-2", "activity", "is", "also", "regulated", "independently", "of", "p105", ",", "since", "C2697656#ent", "<e1>", "stimulation", "was", "still", "needed", "for", "TPL-2-dependent", "activation", "of", "C0752312#ent", "<e2>", "in", "Nfkb1(-/-", ")", "macrophages", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [24, 25]}}
{"token": ["C2697656#ent", "<e1>", "can", "activate", "both", "the", "NF-kappaB", "signaling", "pathway", "C0752312#ent", "<e2>", "signal", "transduction", "pathways", "such", "as", "JNK", "and", "p38", "MAPK"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [9, 10]}}
{"token": ["C2697656#ent", "<e1>", "activates", "PKC", "and", "regulates", "the", "different", "C0752312#ent", "<e2>", "MAPK", ")", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "show", "that", "Set2", "is", "associated", "with", "C1419317#ent", "<e1>", "and", "Rbp2", ",", "the", "two", "largest", "subunits", "of", "C0035680#ent", "<e2>", "RNA", "pol", "II", "."], "h": {"id": "C1419317", "name": "C1419317#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [19, 20]}}
{"token": ["Herein", ",", "we", "demonstrate", "that", "C1336681#ent", "<e1>", "induces", "a", "functional", "C1705050#ent", "<e2>", "transcription", "factor", "in", "that", "C1336681#ent", "<e1>", "stimulation", "results", "in", "Stat5-DNA", "complex", "formation", "and", "transcription", "of", "the", "Stat5-responsive", "gene", "CIS", "."], "h": {"id": "C1705050", "name": "C1705050#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1336681", "name": "C1336681#ent", "pos": [5, 6]}}
{"token": ["Although", "important", "advances", "have", "been", "made", "in", "understanding", "nephrolithiasis", "from", "C0037176#ent", "<e1>", "the", "understanding", "of", "polygenetic", "causes", "of", "C0022650#ent", "<e2>", "still", "largely", "elusive", "."], "h": {"id": "C0037176", "name": "C0037176#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [18, 19]}}
{"token": ["Adriamycin", "(", "C1412244#ent", "<e1>", ")", ",", "bleomycin", "(", "BLM", ")", ",", "methotrexate", "(", "C1417487#ent", "<e2>", ")", ",", "mitomycin-C", "(", "MM-C", ")", ",", "and", "cis-platinum", "(", "cis-DDP", ")", "all", "significantly", "enhanced", "the", "radiation-induced", "skin", "reactions"], "h": {"id": "C1412244", "name": "C1412244#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [13, 14]}}
{"token": ["The", "delay", "in", "propulsion", "was", "reduced", "by", "C0027355#ent", "<e1>", "and", "increased", "by", "C1161352#ent", "<e2>", "and", "two", "general", "anaesthetic", "substances", "but", "was", "unaffected", "by", "a", "number", "of", "other", "pharmacological", "agents"], "h": {"id": "C0027355", "name": "C0027355#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "that", "the", "induction", "of", "C0003927#ent", "<e1>", "not", "require", "C1417932#ent", "<e2>", "activity", "per", "se", "and", "can", "be", "expressed", "in", "the", "absence", "of", "continuous", "polyamine", "synthesis", "."], "h": {"id": "C0003927", "name": "C0003927#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "terrein", "reduces", "melanin", "synthesis", "reducing", "C0041484#ent", "<e1>", "production", "via", "C1370600#ent", "<e2>", "activation", ",", "and", "that", "this", "is", "followed", "by", "MITF", "down-regulation", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [13, 14]}}
{"token": ["These", "results", "demonstrate", "that", "a", "plant", "MEK", "can", "phosphorylate", "and", "activate", "C1370600#ent", "<e1>", ",", "and", "that", "C0041484#ent", "<e2>", "phosphorylation", "is", "critical", "for", "the", "catalytic", "activity", "C1370600#ent", "<e1>", "in", "plants", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [11, 12]}}
{"token": ["Administration", "of", "the", "glutathione", "or", "C0001047#ent", "<e1>", "conjugates", "of", "HCBD", "produced", "a", "marked", "C0022672#ent", "<e2>", "to", "that", "seen", "with", "HCBD", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0022672", "name": "C0022672#ent", "pos": [13, 14]}}
{"token": ["FRAP", "analysis", "that", "the", "decapping", "enzyme", "C2984141#ent", "<e1>", "is", "a", "nondynamic", "PB", "core", "protein", ",", "whereas", "C2984140#ent", "<e2>", "exchanged", "with", "the", "cytoplasm", "."], "h": {"id": "C2984141", "name": "C2984141#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2984140", "name": "C2984140#ent", "pos": [16, 17]}}
{"token": ["C0002555#ent", "<e1>", "interacted", "with", "the", "total", "C0051169#ent", "<e2>", "content", "of", "the", "bovine", "adrenal", "mitochondria", "forming", "low", "spin", "complexes", "."], "h": {"id": "C0002555", "name": "C0002555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [6, 7]}}
{"token": ["The", "C3539768#ent", "<e1>", "Pla2s", ")", "locus", "is", "an", "excellent", "candidate", "for", "C1335221#ent", "<e2>", "and", "the", "equivalent", "human", "locus", "PLA2G2A", "is", "found", "on", "chromosome", "1p35"], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335221", "name": "C1335221#ent", "pos": [11, 12]}}
{"token": ["Rapeseed", "oil", "C0359916#ent", "<e1>", ",", "principally", "vinylsyringol", ",", "raspberry", "anthocyanins", "and", "pinoresinol", "and", "C0127061#ent", "<e2>", ",", "the", "principal", "components", "pine", "bark", "phenolic", "isolate", ",", "were", "effective", "against", "formation", "of", "the", "proinflammatory", "mediator", "prostaglandin", "E(2)"], "h": {"id": "C0359916", "name": "C0359916#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0127061", "name": "C0127061#ent", "pos": [13, 14]}}
{"token": ["Immature", "(", "A2B5(+", ")", ")", "and", "more", "mature", "(", "O4(+", ")", ")", "rat", "oligodendrocyte", "precursors", "in", "dissociated", "cell", "culture", "expressed", "C1424672#ent", "<e1>", "as", "well", "as", "E", "proteins", "C3273649#ent", "<e2>", "and", "E2A", "."], "h": {"id": "C1424672", "name": "C1424672#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3273649", "name": "C3273649#ent", "pos": [27, 28]}}
{"token": ["By", "C0014442#ent", "<e1>", "histochemical", "differentiation", "fiber", "types", ",", "early", "morphological", "changes", "such", "as", "C0338508#ent", "<e2>", "myotonic", "dystrophy", "or", "particular", "disease", "forms", "Type", "II", "atrophy", "congenital", "fiber", "type", "disproportion", "other", "congenital", "myopathies", "associated", "with", "C0338508#ent", "<e2>", "be", "detected", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0338508", "name": "C0338508#ent", "pos": [13, 14]}}
{"token": ["It", "was", "confirmed", "that", "quercetin", ",", "a", "C2348680#ent", "<e1>", ",", "strongly", "suppresses", "the", "generation", "of", "free", "radicals", "active", "oxygen", "species", "UV-exposed", "C0022635#ent", "<e2>", "."], "h": {"id": "C2348680", "name": "C2348680#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022635", "name": "C0022635#ent", "pos": [21, 22]}}
{"token": ["The", "probability", "of", "visual", "field", "constriction", "30", "and", "120", "minutes", "after", "instillation", "of", "C0031923#ent", "<e1>", "was", "found", "to", "be", "significant", ",", "especially", "with", "C0026961#ent", "<e2>", "diameters", "of", "2", "mm", "or", "less", "."], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0026961", "name": "C0026961#ent", "pos": [23, 24]}}
{"token": ["The", "effect", "of", "2", "%", "C0031923#ent", "<e1>", "nitrate", "in", "countering", "C0026961#ent", "<e2>", ",", "cycloplegia", ",", "and", "change", "in", "visual", "acuity", "to", "0.5", "%", "tropicamide", "was", "studied", "in", "23", "healthy", "volunteers"], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0026961", "name": "C0026961#ent", "pos": [10, 11]}}
{"token": ["In", "several", "rodent", "species", "C0031923#ent", "<e1>", "and", "oxotremorine", "produce", "C0026961#ent", "<e2>", ",", "rather", "than", "the", "miosis", "which", "is", "characteristic", "of", "most", "other", "species", "."], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0026961", "name": "C0026961#ent", "pos": [9, 10]}}
{"token": ["Direct", "ICV", "C0031923#ent", "<e1>", "injection", "produces", "C0026961#ent", "<e2>", "at", "doses", "equivalent", "to", "those", "used", "systemically", "."], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0026961", "name": "C0026961#ent", "pos": [6, 7]}}
{"token": ["Point", "mutations", "genomic", "multiplications", "the", "C1420276#ent", "<e1>", "(", "alphaSYN", ")", "gene", "cause", "C0030567#ent", "<e2>"], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [12, 13]}}
{"token": ["Moraxella", "catarrhalis", "an", "important", "cause", "of", "C0029882#ent", "<e1>", "children", "and", "C0041912#ent", "<e2>", "the", "elderly", "."], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "the", "frequency", "of", "C0029882#ent", "<e1>", "Effusion", "(", "OME", ")", "in", "children", "with", "recurrent", "C0041912#ent", "<e2>"], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [15, 16]}}
{"token": ["C0162429#ent", "<e1>", "be", "corrected", "when", "present", "but", ",", "because", "of", "the", "C0236970#ent", "<e2>", "some", "of", "the", "nutritional", "requirements", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0236970", "name": "C0236970#ent", "pos": [11, 12]}}
{"token": ["C0027707#ent", "<e1>", "develops", "during", "continuous", "rifampin", "therapy", ",", "and", "associated", "C1332124#ent", "<e2>", "not", "previously", "been", "reported", "."], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332124", "name": "C1332124#ent", "pos": [10, 11]}}
{"token": ["These", "data", "show", "that", "C0027707#ent", "<e1>", "be", "responsible", "for", "distal", "tubular", "abnormalities", "namely", "C1332124#ent", "<e2>", "distal", "tubular", "acidosis", "which", "may", "persist", "long", "after", "the", "onset", "of", "the", "nephropathy", "."], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332124", "name": "C1332124#ent", "pos": [13, 14]}}
{"token": ["in", "SHRs", ",", "C0668779#ent", "<e1>", "produced", "significantly", "greater", "changes", "in", "C3887648#ent", "<e2>", "and", "dopamine", "content", ",", "as", "compared", "to", "the", "R-enantiomer", "(", "RS-25560", "-", "198", ")", ",", "in", "the", "mesenteric", "artery", "left", "ventricle"], "h": {"id": "C0668779", "name": "C0668779#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "C1425724#ent", "<e1>", "as", "well", "as", "the", "non-lymphocyte", "cell", "lines", "HeLa", "and", "C1708807#ent", "<e2>", "cleaved", "the", "F", "protein", "precursor", "."], "h": {"id": "C1425724", "name": "C1425724#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1708807", "name": "C1708807#ent", "pos": [14, 15]}}
{"token": ["Rosiglitazone", "treatment", "decreases", "insulin", "resistance", "C0011860#ent", "<e1>", "patients", ",", "but", "no", "data", "exist", "concerning", "C0289313#ent", "<e2>", "treatment", "of", "patients", "with", "syndromes", "of", "extreme", "insulin", "resistance"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [14, 15]}}
{"token": ["The", "question", "of", "whether", "serum", "NT-BNP", "is", "a", "predictive", "index", "of", "heart", "failure", "answers", "given", "by", "more", "observation", "on", "C0011860#ent", "<e1>", "patients", "using", "C0289313#ent", "<e2>", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [23, 24]}}
{"token": ["She", "remained", "in", "coma", "with", "frequent", "C0751495#ent", "<e1>", "for", "1", "wk", ",", "with", "persisting", "severe", "C1839163#ent", "<e2>", "and", "microangiopathic", "haemolytic", "anaemia", "despite", "treatment", "with", "prednisolone", ",", "plasma", "exchange", "fresh", "frozen", "plasma", "sulphinpyrazone", "and", "dipyridamole", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "C1415782#ent", "<e1>", "has", "both", "C0002842#ent", "<e2>", "pro-apoptotic", "roles", "."], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [7, 8]}}
{"token": ["There", "was", "no", "effect", "C1705516#ent", "<e1>", "inhibition", "on", "plasma", "ANF", "levels", "or", "C3669212#ent", "<e2>", "in", "either", "the", "virgin", "or", "pregnant", "rats"], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3669212", "name": "C3669212#ent", "pos": [12, 13]}}
{"token": ["The", "myometrial", "contractile", "responses", "synthetic", "1", "0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine", "(", "platelet-activating", "factor", "C0235480#ent", "<e1>", ")", "and", "to", "oxytocin", "were", "evaluated", "in", "vitro", "C0567085#ent", "<e2>", "(", "lower", "segment", "strips", "obtained", "from", "pregnant", "women", "term", "(", "39th", "week", ")", ",", "undergoing", "elective", "cesarean", "section"], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [20, 21]}}
{"token": ["Impairment", "of", "the", "fertility", "in", "the", "platelet-activating", "factor", "C0235480#ent", "<e1>", ")", "receptor", "transgenic", "female", "mice", "suggests", "changes", "in", "C0235480#ent", "<e1>", "functions", "can", "influence", "C0567085#ent", "<e1>", "receptivity", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [23, 24]}}
{"token": ["On", "the", "other", "hand", ",", "C0235480#ent", "<e1>", "at", "10(-8", ")", "M", "failed", "to", "alter", "the", "C0567085#ent", "<e2>", "basal", "production", "of", "14CO2", "from", "labelled", "glucose", "in", "animals", "at", "estrus", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [15, 16]}}
{"token": ["C0020336#ent", "<e1>", "rarely", "used", "in", "the", "treatment", "of", "C0162566#ent", "<e2>", "PCT", ")", "."], "h": {"id": "C0020336", "name": "C0020336#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [8, 9]}}
{"token": ["C0020336#ent", "<e1>", "rarely", "used", "in", "the", "treatment", "of", "porphyria", "cutanea", "tarda", "C0162566#ent", "<e2>", ")", "."], "h": {"id": "C0020336", "name": "C0020336#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [11, 12]}}
{"token": ["C0020336#ent", "<e1>", "and", "phlebotomy", "were", "compared", "in", "the", "treatment", "of", "C0162566#ent", "<e2>", "PCT", ")", "."], "h": {"id": "C0020336", "name": "C0020336#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [10, 11]}}
{"token": ["Ndell", "is", "also", "involved", "in", "the", "regulation", "of", "microtubule", "organization", "and", "becomes", "the", "target", "of", "various", "C0031727#ent", "<e1>", "and", "phosphatases", ",", "including", "CDK5/CDK1", ",", "C0971285#ent", "<e2>", "and", "PP4", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [16, 17]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0971285", "name": "C0971285#ent", "pos": [24, 25]}}
{"token": ["The", "common", "feature", "of", "this", "form", "of", "C3668816#ent", "<e1>", "is", "the", "possibility", "of", "evolving", "towards", "recurrent", "C0000833#ent", "<e2>"], "h": {"id": "C3668816", "name": "C3668816#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [16, 17]}}
{"token": ["Adult", "rats", "were", "intranigrally", "infused", "with", "muscimol", "(", "GABAA", "receptor", "agonist", ",", "bicuculline", "(", "C0242975#ent", "<e1>", "or", "baclofen", "(", "GABAB", "receptor", "agonist", "and", "were", "exposed", "to", "C0036572#ent", "<e2>"], "h": {"id": "C0242975", "name": "C0242975#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [26, 27]}}
{"token": ["On", "the", "other", "hand", ",", "infusion", "of", "a", "C0242975#ent", "<e1>", "bicuculline", ")", "into", "the", "PPN", "revealed", "a", "protective", "effect", "C0036572#ent", "<e2>", "."], "h": {"id": "C0242975", "name": "C0242975#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [19, 20]}}
{"token": ["The", "comparative", "behavioral", "neurochemical", "activities", "of", "the", "muscarinic", "cholinergic", "antagonists", "scopolamine", ",", "C0003830#ent", "<e1>", "and", "pirenzepine", ",", "and", "the", "C0242956#ent", "<e2>", "mecamylamine", "were", "evaluated", "in", "rats", "."], "h": {"id": "C0003830", "name": "C0003830#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242956", "name": "C0242956#ent", "pos": [19, 20]}}
{"token": ["The", "cellular", "prion", "protein", "PrPc", ")", "is", "a", "glycolipid-anchored", ",", "cell", "surface", "protein", "unknown", "function", ",", "a", "posttranslationally", "modified", "isoform", "of", "which", "PrPSc", "is", "involved", "in", "the", "pathogenesis", "of", "C0022336#ent", "<e1>", "scrapie", ",", "and", "other", "C0162534#ent", "<e2>"], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [29, 30]}, "relation": "has_nichd_parent", "t": {"id": "C0162534", "name": "C0162534#ent", "pos": [35, 36]}}
{"token": ["The", "C0281398#ent", "<e1>", "negative", "in", "23", "cats", "diagnosed", "with", "varying", "underlying", "C0012634#ent", "<e2>", "and", "in", "47", "healthy", "control", "cats", "with", "platelet", "values", "within", "the", "reference", "range"], "h": {"id": "C0281398", "name": "C0281398#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["Endogenous", "C0812278#ent", "<e1>", "binds", "to", "immobilised", "C1424988#ent", "<e2>", "and", "endogenous", "C1424988#ent", "<e2>", "binds", "to", "immobilised", "C0812278#ent", "<e1>", "."], "h": {"id": "C0812278", "name": "C0812278#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1424988", "name": "C1424988#ent", "pos": [6, 7]}}
{"token": ["We", "previously", "showed", "that", "C1412731#ent", "<e1>", "a", "member", "of", "the", "BAG", "(", "C3816451#ent", "<e2>", "co-chaperone", "family", "modulates", "apoptosis", "in", "human", "leukemias", "."], "h": {"id": "C1412731", "name": "C1412731#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3816451", "name": "C3816451#ent", "pos": [12, 13]}}
{"token": ["We", "feel", "that", "C0038826#ent", "<e1>", "always", "be", "a", "concern", "in", "patients", "with", "C1275687#ent", "<e2>", "even", "early", "in", "their", "often", "prolonged", "chronic", "disease"], "h": {"id": "C0038826", "name": "C0038826#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1275687", "name": "C1275687#ent", "pos": [12, 13]}}
{"token": ["In", "this", "respect", "C0075493#ent", "<e1>", "differs", "from", "such", "other", "C3536840#ent", "<e2>", "indomethacin", "and", "naproxen", "."], "h": {"id": "C0075493", "name": "C0075493#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536840", "name": "C3536840#ent", "pos": [9, 10]}}
{"token": ["The", "C0014442#ent", "<e1>", "responsible", "for", "the", "addition", "of", "O-fucose", "to", "epidermal", "growth", "factor-like", "repeats", "C1538692#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538692", "name": "C1538692#ent", "pos": [14, 15]}}
{"token": ["The", "C0014442#ent", "<e1>", "adding", "fucose", "to", "EGF-like", "repeats", "C1538692#ent", "<e2>", "Pofut1", ")", ",", "is", "a", "soluble", "protein", "located", "in", "the", "lumen", "of", "endoplasmic", "reticulum", "ER", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538692", "name": "C1538692#ent", "pos": [8, 9]}}
{"token": ["8-OH-DPAT", ",", "a", "selective", "C1415803#ent", "<e1>", "and", "mCPP", ",", "which", "has", "preferential", "affinity", "for", "C1415804#ent", "<e2>", "and", "5-HT1C", "receptors", "were", "studied", "for", "their", "effects", "on", "aversive", "brain", "stimulation", "rats", "."], "h": {"id": "C1415803", "name": "C1415803#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415804", "name": "C1415804#ent", "pos": [14, 15]}}
{"token": ["After", "bone", "marrow", "grafting", "bacterial", "pneumonia", "fungal", "pneumonia", "bronchitis", ",", "mixed", "bacterial", "and", "fungal", "pneumonia", "C0206061#ent", "<e1>", "unclear", "pulmonary", "infiltrates", "idiopathic", "interstitial", "pneumonia", "pneumonia", "due", "to", "rare", "pathogens", ",", "C0865791#ent", "<e2>", "and", "ARDS", "can", "occur", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0865791", "name": "C0865791#ent", "pos": [29, 30]}}
{"token": ["A", "trial", "of", "special", "diet", "restriction", "of", "very", "long", "chain", "fatty", "acid", "and", "addition", "of", "C0041073#ent", "<e1>", "GTEO", "or", "C0212874#ent", "<e2>", "failed", "to", "prevent", "clinical", "deterioration"], "h": {"id": "C0041073", "name": "C0041073#ent", "pos": [15, 16]}, "relation": "product_component_of", "t": {"id": "C0212874", "name": "C0212874#ent", "pos": [19, 20]}}
{"token": ["CE", "ratios", "tend", "to", "be", "unfavorably", "skewed", "in", "the", "case", "of", "C0008679#ent", "<e1>", "such", "as", "C0343755#ent", "<e2>", "because", "management", "of", "AIDS", "patients", "is", "costly", "and", "complex", "."], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0343755", "name": "C0343755#ent", "pos": [15, 16]}}
{"token": ["C3539709#ent", "<e1>", "and", "APOA1", "markers", "were", "in", "C0394006#ent", "<e2>", "the", "patients", "and", "both", "of", "them", "were", "associated", "with", "LDL", "."], "h": {"id": "C3539709", "name": "C3539709#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [7, 8]}}
{"token": ["C3539709#ent", "<e1>", "and", "ACE", ",", "C3539709#ent", "<e1>", "and", "APOA1", "were", "in", "C0394006#ent", "<e1>", "the", "control", "group"], "h": {"id": "C3539709", "name": "C3539709#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [11, 12]}}
{"token": ["Although", "expression", "of", "C0919336#ent", "<e1>", "and", "TIMP", "mRNA", "was", "highly", "intercorrelated", ",", "transcripts", "for", "C0174383#ent", "<e2>", "TIMP-2", "(", "high", ")", "showed", "the", "strongest", "relation", "to", "the", "neoplastic", "process", "."], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0174383", "name": "C0174383#ent", "pos": [14, 15]}}
{"token": ["Human", "Single-minded", "1", "C1420067#ent", "<e1>", ")", "and", "SIM2", "genes", "found", "as", "C4277608#ent", "<e2>", "of", "Drosophila", "sim", "gene", "plays", "a", "key", "role", "in", "the", "midline", "cell", "lineage", "of", "the", "central", "nervous", "system"], "h": {"id": "C1420067", "name": "C1420067#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [11, 12]}}
{"token": ["We", "hypothesized", "that", "interactions", "of", "tissue", "plasminogen", "activator", "C0078956#ent", "<e1>", ")", "with", "Plg", "kringle", "domains", "plasmin", "levels", "patients", "with", "stable", "C1956346#ent", "<e2>", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [20, 21]}}
{"token": ["Elevated", "levels", "of", "tissue-type", "plasminogen", "activator", "antigen", "C0078956#ent", "<e1>", ")", ",", "fibrinogen", ",", "and", "fibrin", "D-dimer", "C1956346#ent", "<e2>", "CAD", ")", "events", "and", "stroke", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [16, 17]}}
{"token": ["Adult-onset", "type", "II", "citrullinaemia", "caused", "by", "deficiency", "of", "the", "citrin", "protein", "encoded", "by", "the", "C1420154#ent", "<e1>", "is", "characterised", "by", "a", "C0175683#ent", "<e2>"], "h": {"id": "C1420154", "name": "C1420154#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0175683", "name": "C0175683#ent", "pos": [20, 21]}}
{"token": ["In", "addition", "to", "[3H]TCDD", ",", "specific", "binding", "to", "C1706481#ent", "<e1>", "A431", "cytosol", "also", "was", "detected", "with", "[3H]3-methylcholanthrene", "and", "with", "C0005080#ent", "<e2>", "as", "radioligands", "."], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005080", "name": "C0005080#ent", "pos": [19, 20]}}
{"token": ["The", "C0671924#ent", "<e1>", "acetylates", "H3", "and", "also", "C1425774#ent", "<e2>", ",", "whereas", "enzyme", "A2", "specific", "for", "H3", "."], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1425774", "name": "C1425774#ent", "pos": [7, 8]}}
{"token": ["In", "conclusion", ",", "C0539305#ent", "<e1>", "could", "be", "both", "an", "C3537168#ent", "<e2>", "and", "antihypertensive", "agent", "because", "of", "its", "dual", "activities"], "h": {"id": "C0539305", "name": "C0539305#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537168", "name": "C3537168#ent", "pos": [9, 10]}}
{"token": ["In", "mouse", "skin", "double", "treatments", "C0960309#ent", "<e1>", "810", "nmol", ")", "significantly", "suppressed", "double", "12-O-tetradecanoylphorbol-13-acetate", "C0872913#ent", "<e2>", ",", "8.1", "nmol", ")", "application-induced", "hydrogen", "peroxide", "(", "H2O2", ")", "generation", "."], "h": {"id": "C0960309", "name": "C0960309#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0872913", "name": "C0872913#ent", "pos": [14, 15]}}
{"token": ["We", "have", "identified", "a", "promoter", "in", "the", "region", "of", "malK", ",", "the", "C0079429#ent", "<e1>", "immediately", "preceding", "C0406810#ent", "<e2>", ",", "which", "is", "active", "in", "minicells", "but", "relatively", "inactive", "in", "vitro"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0406810", "name": "C0406810#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "suggest", "direct", "extension", "of", "chronic", "inflammation", "bronchioles", "to", "the", "adjacent", "muscular", "pulmonary", "arteries", "in", "C0008677#ent", "<e1>", "not", "in", "C0034067#ent", "<e2>"], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0034067", "name": "C0034067#ent", "pos": [20, 21]}}
{"token": ["In", "34", "cases", "of", "chronic", "bronchial", "infection", "the", "mean", "age", "59.8", "years", ",", "underlying", "diseases", "included", "bronchiectasis", "10", ",", "C0008677#ent", "<e1>", ",", "inactive", "pulmonary", "tuberculosis", ",", "diffuse", "panbronchiolitis", "5", "and", "C0034067#ent", "<e2>"], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [19, 20]}, "relation": "related_to", "t": {"id": "C0034067", "name": "C0034067#ent", "pos": [30, 31]}}
{"token": ["Various", "definitions", "have", "been", "gradually", "developed", "and", "C0008677#ent", "<e1>", "separated", "from", "C0034067#ent", "<e2>"], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0034067", "name": "C0034067#ent", "pos": [11, 12]}}
{"token": ["The", "continued", "efficacy", "of", "carbapenems", "such", "as", "C0541153#ent", "<e1>", "confirms", "that", "these", "remain", "first-line", "agents", "treatment", "of", "C0205721#ent", "<e2>", "by", "Enterobacteriaceae-producing", "ESBL", "or", "AmpC", "beta-lactamases"], "h": {"id": "C0541153", "name": "C0541153#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0205721", "name": "C0205721#ent", "pos": [17, 18]}}
{"token": ["Integrin", "activation", "increased", "phosphorylation", "levels", "of", "C0257151#ent", "<e1>", "MEK", ")", "and", "C1705791#ent", "<e2>", "phosphorylation", "as", "well", "."], "h": {"id": "C0257151", "name": "C0257151#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [11, 12]}}
{"token": ["Intra-AcbC", "infusions", "of", "U0126", ",", "an", "inhibitor", "of", "the", "C0257151#ent", "<e1>", "MEK", ",", "prevent", "both", "the", "activation", "of", "C1705791#ent", "<e2>", ",", "CREB", ",", "Elk-1", ",", "and", "Fos", "and", "retrieval", "of", "COC-CPP", "."], "h": {"id": "C0257151", "name": "C0257151#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [18, 19]}}
{"token": ["Use", "of", "U0126", "revealed", "that", "palytoxin", "requires", "the", "C0257151#ent", "<e1>", "MEK", "to", "stimulate", "C1705791#ent", "<e2>", "activity", ",", "although", "palytoxin", "did", "not", "activate", "MEK", "."], "h": {"id": "C0257151", "name": "C0257151#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [13, 14]}}
{"token": ["The", "study", "population", "the", "first", "100", "participants", "in", "a", "C0021847#ent", "<e1>", "substudy", "of", "25-", "to", "34-yr-old", "subjects", "with", "C1852092#ent", "<e2>", "part", "in", "a", "cohort", "follow-up", "study"], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1852092", "name": "C1852092#ent", "pos": [18, 19]}}
{"token": ["Case", "2", "started", "having", "C0700200#ent", "<e1>", "after", "an", "attack", "of", "C0025007#ent", "<e2>", "at", "the", "age", "of", "8", "years", ",", "at", "which", "time", "she", "probably", "acquired", "some", "damage", "to", "her", "myocardium", "."], "h": {"id": "C0700200", "name": "C0700200#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025007", "name": "C0025007#ent", "pos": [10, 11]}}
{"token": ["Prevalence", "of", "autoantibodies", "against", "IA-2", "(", "IA-2A", ")", ",", "glutamic", "acid", "decarboxylase", "GADA", ")", ",", "and", "C0012920#ent", "<e1>", "TopIIA", ")", "of", "C0011860#ent", "<e2>", "T1DM", ")", "patients", "was", "investigated", "."], "h": {"id": "C0012920", "name": "C0012920#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [21, 22]}}
{"token": ["Reproducible", "and", "significant", "inductions", "were", "observed", "in", "a", "limited", "number", "of", "C0017337#ent", "<e1>", "including", "CYP1A1", "and", "C1620185#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [16, 17]}}
{"token": ["Drug", "interactions", "a", "major", "issue", ",", "and", "a", "full", "knowledge", "of", "the", "C0022173#ent", "<e1>", "protein-binding", "characteristics", "of", "each", "C1254351#ent", "<e2>", "(", "antiepileptic", "and", "other", ")", "must", "be", "known", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["To", "understand", "the", "function", "of", "C0065661#ent", "<e1>", "in", "relation", "to", "infectious", "C0162628#ent", "<e2>", "chicken", "lines", "selected", "for", "high", "and", "low", "concentrations", "of", "C0065661#ent", "<e1>", "in", "serum", "for", "several", "generations", "."], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0065661", "name": "C0065661#ent", "pos": [5, 6]}}
{"token": ["In", "spite", "of", "this", ",", "multifactorial", "pathogenesis", "in", "the", "elderly", "would", "require", "a", "search", "for", "causes", "other", "than", "C0011847#ent", "<e1>", "even", "in", "asymmetrically", "distributed", "C0206247#ent", "<e2>", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0206247", "name": "C0206247#ent", "pos": [24, 25]}}
{"token": ["Inhibition", "of", "endothelium", "function", "L-NAME", "and", "indomethacin", "reduced", "C1412382#ent", "<e1>", "073-induced", "relaxation", "of", "the", "vessel", "precontracted", "with", "C0031469#ent", "<e2>", ",", "but", "not", "with", "125", "mM", "K(+", ")", "."], "h": {"id": "C1412382", "name": "C1412382#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [17, 18]}}
{"token": ["The", "same", "C1705979#ent", "<e1>", "levels", "were", "measured", "in", "26", "C3890176#ent", "<e2>", "patients", "receiving", "UVB", "plus", "tar", "therapy"], "h": {"id": "C1705979", "name": "C1705979#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3890176", "name": "C3890176#ent", "pos": [9, 10]}}
{"token": ["La(3+)-induced", "effects", "essentially", "differ", "from", "each", "other", "in", "C1424858#ent", "<e1>", "(", "right", "parietal", "1", ")", "and", "C3812695#ent", "<e2>", "(", "left", "parietal", "3", "neurons", "."], "h": {"id": "C1424858", "name": "C1424858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3812695", "name": "C3812695#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "in", "B", "lymphoblast", "cell", "extracts", "the", "rapid", "degradation", "of", "these", "C0005220#ent", "<e1>", "constructs", "required", "C2744579#ent", "<e2>", "and", "ubiquitin", "and", "was", "blocked", "by", "inhibitors", "of", "proteasomes", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [16, 17]}}
{"token": ["At", "any", "time", "the", "secretion", "of", "acid", "hydrolases", "beta-N-acetylglucosaminidase", ",", "beta-glucuronidase", "and", "C0005220#ent", "<e1>", "was", "inhibited", "to", "a", "greater", "extent", "than", "secretion", "of", "C2744579#ent", "<e2>", "plus", "ADP", "(", "dense-granule", "secretion", ")", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [23, 24]}}
{"token": ["C1412573#ent", "<e1>", "AC", ")", "is", "the", "C0391845#ent", "<e2>", "degrades", "ceramide", "into", "sphingosine", "and", "fatty", "acid"], "h": {"id": "C1412573", "name": "C1412573#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [6, 7]}}
{"token": ["It", "is", "concluded", "that", ":", "the", "C1538681#ent", "<e1>", "of", "the", "surge", "inhibits", "both", "the", "17", "C0599930#ent", "<e2>", "and", "lyase", "activities"], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0599930", "name": "C0599930#ent", "pos": [15, 16]}}
{"token": ["We", "recently", "reported", "that", "treatment", "of", "mouse", "Leydig", "cell", "for", "5", "days", "with", "C1538681#ent", "<e1>", "or", "cAMP", "caused", "an", "induction", "of", "the", "microsomal", "cytochrome", "P-450", "17", "C0599930#ent", "<e2>", "and", "C17", "-", "20", "lyase", "."], "h": {"id": "C1538681", "name": "C1538681#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0599930", "name": "C0599930#ent", "pos": [26, 27]}}
{"token": ["The", "recessive", "xa13", "C1706112#ent", "<e1>", "represents", "a", "new", "type", "of", "C0032080#ent", "<e2>", "resistance", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032080", "name": "C0032080#ent", "pos": [10, 11]}}
{"token": ["Cholinergic", "signals", "evoked", "by", "C0666155#ent", "<e1>", "were", "more", "efficaciously", "attenuated", "by", "the", "relatively", "C3273872#ent", "<e2>", "nAChR", "antagonist", "."], "h": {"id": "C0666155", "name": "C0666155#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [13, 14]}}
{"token": ["The", "patient", "did", "not", "manifest", "symptoms", "of", "C0024586#ent", "<e1>", "had", "no", "echocardiographic", "or", "MRI", "evidence", "of", "C0018824#ent", "<e2>"], "h": {"id": "C0024586", "name": "C0024586#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [16, 17]}}
{"token": ["The", "C1366521#ent", "<e1>", "immediate", "activation", "events", "of", "STAT6", "were", "not", "affected", "by", "C1705633#ent", "<e2>", "MAPK", "activity", "."], "h": {"id": "C1366521", "name": "C1366521#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [12, 13]}}
{"token": ["Glyceryl", "trinitrate", "C0022252#ent", "<e1>", "and", "isosorbide-5-mononitrate", "are", "organic", "nitrate", "esters", "used", "in", "the", "treatment", "of", "C0002962#ent", "<e2>", "myocardial", "infarction", "and", "congestive", "heart", "failure"], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [2, 3]}, "relation": "may_prevent", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [15, 16]}}
{"token": ["Twelve", "patients", "were", "entered", "prospectively", "into", "a", "randomized", "double-blind", "study", "the", "efficacy", "of", "nifedipine", "and", "C0022252#ent", "<e1>", "ISDN", ")", "in", "the", "treatment", "of", "C0002962#ent", "<e2>", "to", "coronary", "artery", "spasm"], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [15, 16]}, "relation": "may_prevent", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [23, 24]}}
{"token": ["Intracoronary", "administration", "C0022252#ent", "<e1>", "1", "mg", ")", "relieved", "the", "C0002962#ent", "<e2>", "dilated", "all", "vessels", "."], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [2, 3]}, "relation": "may_prevent", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [9, 10]}}
{"token": ["Because", "hypercalcemia", ",", "elevated", "parathyroid", "hormone", "levels", ",", "and", "radiologic", "changes", "said", "to", "be", "typical", "of", "C0031111#ent", "<e1>", "occur", "with", "aluminum", "intoxication", "it", "is", "frequently", "confused", "with", "C1840402#ent", "<e2>", "."], "h": {"id": "C0031111", "name": "C0031111#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [27, 28]}}
{"token": ["C0031111#ent", "<e1>", "the", "bone", "changes", "seen", "in", "renal", "osteodystrophy", "secondary", "to", "C1840402#ent", "<e2>", "."], "h": {"id": "C0031111", "name": "C0031111#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [11, 12]}}
{"token": ["Both", "FGF-2", "and", "C3539526#ent", "<e1>", "upregulated", "the", "phosphorylation", "of", "cellular", "proteins", "including", "extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e2>", ")", ",", "and", "increased", "the", "kinase", "activity", "immunoprecipitated", "FGFR1", "and", "Tyro", "3", ",", "respectively", ",", "in", "mouse", "osteoclasts", "."], "h": {"id": "C3539526", "name": "C3539526#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [15, 16]}}
{"token": ["C3539526#ent", "<e1>", "up-regulated", "the", "phosphorylation", "of", "cellular", "proteins", "p42/p44", "mitogen-activated", "protein", "kinase", "C1370600#ent", "<e2>", ")", ",", "but", "not", "p38", "or", "c-Jun", "N-terminal", "kinase", "MAPK", "and", "increased", "the", "kinase", "activity", "immunoprecipitated", "Tyro", "3", "in", "isolated", "osteoclasts", "."], "h": {"id": "C3539526", "name": "C3539526#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [12, 13]}}
{"token": ["5", "were", "suffering", "from", "septicaemia", ",", "14", "from", "C0877203#ent", "<e1>", "were", "ventilated", "(", "intensive", "care", "unit", ",", "4", "from", "C0042029#ent", "<e2>", "3", "from", "otitis", "media", "complicated", "with", "renal", "failure", "nephrology", "unit", "."], "h": {"id": "C0877203", "name": "C0877203#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [19, 20]}}
{"token": ["When", "transformed", "and", "induced", "in", "Escherichia", "coli", "the", "two", "constructs", "produce", "C0017837#ent", "<e1>", "GPIIIa", "fusion", "proteins", "one", "containing", "leucine", "at", "position", "33", "(", "C0031666#ent", "<e2>", ")", ",", "the", "other", "proline", "(", "PlA2", ")", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031666", "name": "C0031666#ent", "pos": [23, 24]}}
{"token": ["In", "horses", ",", "increased", "CRP", "concentration", "was", "associated", "with", "C3714582#ent", "<e1>", "enteritis", ",", "and", "C0029408#ent", "<e2>", ",", "compared", "with", "values", "obtained", "in", "clinically", "normal", "horses", "by", "use", "of", "single", "radial", "immunodiffusion", "method"], "h": {"id": "C3714582", "name": "C3714582#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [14, 15]}}
{"token": ["She", "had", "no", "signs", "of", "C3494506#ent", "<e1>", "AHO", ")", ",", "a", "normal", "mental", "status", "no", "family", "history", "C0020598#ent", "<e2>", "or", "any", "other", "endocrine", "disease"], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0020598", "name": "C0020598#ent", "pos": [17, 18]}}
{"token": ["The", "sisters", "were", "affected", "by", "C3494506#ent", "<e1>", "the", "older", "manifested", "the", "C0020598#ent", "<e2>", "variety", ",", "the", "younger", "the", "normocalcemic", "variety", ";", "the", "mother", "and", "the", "grandfather", "presented", "only", "with", "short", "stature", "subcutaneous", "calcifications"], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0020598", "name": "C0020598#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "C0054201#ent", "<e1>", "exert", "an", "anti-inflammatory", "effect", "on", "intestinal", "epithelial", "cells", "which", "may", "contribute", "to", "the", "overall", "action", "of", "C0054201#ent", "<e1>", "in", "the", "treatment", "of", "C0021390#ent", "<e1>"], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [27, 28]}}
{"token": ["C0003195#ent", "<e1>", "as", "quinidine", "sulfate", "procainamide", ",", "disopyramide", ",", "C0025887#ent", "<e2>", ",", "lidocaine", "and", "propranolol", "were", "not", "effective", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [0, 1]}, "relation": "therapeutic_class_of", "t": {"id": "C0025887", "name": "C0025887#ent", "pos": [9, 10]}}
{"token": ["This", "review", "focuses", "on", "these", "recent", "advances", "in", "neuroimaging", "technology", "their", "use", "for", "the", "diagnosis", "and", "assessment", "of", "C3160718#ent", "<e1>", "and", "other", "C0242422#ent", "<e2>"], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [18, 19]}, "relation": "has_manifestation", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [22, 23]}}
{"token": ["Sebaceous", "nevus", "SN", ")", "syndrome", "is", "a", "C0037274#ent", "<e1>", "by", "a", "distinctive", "skin", "lesion", "association", "with", "C0014544#ent", "<e2>", "and", "mental", "retardation"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [16, 17]}}
{"token": ["At", "the", "same", "time", ",", "an", "increasing", "number", "of", "mutations", "of", "connexin", "genes", "been", "linked", "to", "several", "hereditary", "diseases", "including", "peripheral", "neuropathies", "C0037274#ent", "<e1>", "genetic", "deafness", "cataracts", "and", "some", "forms", "of", "C0014544#ent", "<e2>", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [31, 32]}}
{"token": ["We", "report", "a", "case", "of", "13-year-old-girl", "with", "C0035372#ent", "<e1>", "effectiveness", "of", "gastrostomy", "for", "severe", "paradoxical", "respiration", "C0036572#ent", "<e2>", "and", "abdominal", "distention"], "h": {"id": "C0035372", "name": "C0035372#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [16, 17]}}
{"token": ["Death", "was", "attributed", "to", "the", "complications", "of", "C0035372#ent", "<e1>", "an", "uncommon", "developmental", "disorder", "characterized", "by", "autistic", "type", "behaviour", "hypotonia", ",", "stereotyped", "movements", "C0036572#ent", "<e2>", "and", "growth", "failure", "caused", "by", "mutations", "in", "the", "MECP2", "gene", "the", "X", "chromosome"], "h": {"id": "C0035372", "name": "C0035372#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "show", "that", "C1424597#ent", "<e1>", "also", "cleaves", "the", "C1539051#ent", "<e2>", "anaphase", "onset"], "h": {"id": "C1424597", "name": "C1424597#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539051", "name": "C1539051#ent", "pos": [9, 10]}}
{"token": ["C0277556#ent", "<e1>", "their", "treatment", "may", "have", "an", "impact", "on", "the", "C0014544#ent", "<e2>", "and", "its", "treatment", "."], "h": {"id": "C0277556", "name": "C0277556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [10, 11]}}
{"token": ["Colonic", "volvulus", "association", "with", "C0267494#ent", "<e1>", "treated", "based", "on", "the", "location", "of", "the", "C0042961#ent", "<e2>", "."], "h": {"id": "C0267494", "name": "C0267494#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042961", "name": "C0042961#ent", "pos": [13, 14]}}
{"token": ["Bowman's", "layer", "corneal", "dystrophies", "CDBs", ")", "include", "2", "distinct", "types", ":", "C0339278#ent", "<e1>", ",", "or", "Reis-B\u00fccklers", "(", "RBCD", ")", ",", "and", "C1413251#ent", "<e2>", ",", "or", "Thiel-Behnke", "(", "TBCD", ")", "."], "h": {"id": "C0339278", "name": "C0339278#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413251", "name": "C1413251#ent", "pos": [21, 22]}}
{"token": ["guanethidine", "(", "8", "mg/kg", ")", ",", "or", "pretreatment", "with", "the", "C0006931#ent", "<e1>", "resiniferatoxin", "did", "not", "reduce", "the", "vasodilator", "response", "C0010648#ent", "<e2>", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010648", "name": "C0010648#ent", "pos": [19, 20]}}
{"token": ["Otherwise", "duodenal", "SP-li", "was", "not", "sensitive", "to", "C0006931#ent", "<e1>", "pretreatment", "and", "its", "duodenal", "content", "decreased", "by", "C0010648#ent", "<e2>", "originates", "from", "an", "intrinsic", "source", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010648", "name": "C0010648#ent", "pos": [16, 17]}}
{"token": ["C0043443#ent", "<e1>", "blocks", "histamine", "H(1)", "receptors", "stabilises", "mast", "cells", "and", "prevents", "C1306759#ent", "<e2>", "accumulation", "."], "h": {"id": "C0043443", "name": "C0043443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [11, 12]}}
{"token": ["This", "gene", "was", "found", "to", "be", "related", "to", "a", "group", "of", "C0017337#ent", "<e1>", "that", "encodes", "cysteine", "protease", "inhibitors", "known", "as", "C0010646#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010646", "name": "C0010646#ent", "pos": [20, 21]}}
{"token": ["The", "C1366571#ent", "<e1>", "level", "in", "the", "CSF", "of", "patients", "with", "C0025290#ent", "<e2>", "not", "differ", "from", "that", "in", "the", "CSF", "of", "the", "patients", "with", "gastroenteritis", "(", "less", "than", "30", "pg/ml", ")", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025290", "name": "C0025290#ent", "pos": [10, 11]}}
{"token": ["These", "data", "indicate", "that", "C1366571#ent", "<e1>", "levels", "rise", "transiently", "at", "the", "initial", "stage", "of", "C0025290#ent", "<e2>", "and", "that", "mononuclear", "cells", "migrate", "into", "the", "CSF", "are", "a", "cellular", "source", "this", "chemokine", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025290", "name": "C0025290#ent", "pos": [14, 15]}}
{"token": ["The", "authors", "report", "a", "patient", "with", "C2931257#ent", "<e1>", "AD", ")", "without", "C0014038#ent", "<e2>", "who", "was", "immunized", "with", "AN-1792", "(", "an", "adjuvanted", "formulation", "Abeta-42", ")", "."], "h": {"id": "C2931257", "name": "C2931257#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [11, 12]}}
{"token": ["The", "present", "study", "was", "gned", "to", "investigate", "C1419846#ent", "<e1>", "regulation", "in", "adipocytes", "by", "examining", "the", "C1421224#ent", "<e2>", "glucose", "and", "insulin", "on", "C1419846#ent", "<e1>", "expression", "."], "h": {"id": "C1419846", "name": "C1419846#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421224", "name": "C1421224#ent", "pos": [15, 16]}}
{"token": ["We", "reviews", "the", "use", "of", "calcium-channel", "blockers", "C0205911#ent", "<e1>", "(", "and", "analogues", ")", ",", "endothelin-receptor", "antagonists", "and", "C0031638#ent", "<e2>", "and", "the", "use", "of", "combination", "therapy", "and", "provides", "specific", "recommendations", "about", "the", "actual", "treatment", "."], "h": {"id": "C0205911", "name": "C0205911#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031638", "name": "C0031638#ent", "pos": [17, 18]}}
{"token": ["But", "recently", "'", "specific", "therapies", "'", "(", "i.e.", ",", "therapies", "targeting", "specific", "pathogenic", "pathways", "have", "become", "available", ";", "these", "are", "therapies", "represented", "by", "C0205911#ent", "<e1>", "and", "its", "derivatives", ",", "endothelin", "receptor", "antagonists", "C0031638#ent", "<e2>"], "h": {"id": "C0205911", "name": "C0205911#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0031638", "name": "C0031638#ent", "pos": [32, 33]}}
{"token": ["Each", "of", "the", "enzyme", "systems", "investigated", "(", "glucose-6-phosphate", "dehydrogenase", "C0017759#ent", "<e1>", "6-phosphogluconate", "dehydrogenase", "peptidases", "A", "B", "and", "D", ",", "and", "C1418516#ent", "<e2>", ")", "was", "diagnostic", "for", "at", "least", "one", "species", "."], "h": {"id": "C0017759", "name": "C0017759#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418516", "name": "C1418516#ent", "pos": [20, 21]}}
{"token": ["Analysis", "of", "Western", "European", "of", "Asellus", "aquaticus", "10", "electrophoretic", "phenotypes", "of", "C0017759#ent", "<e1>", "GPI", ")", "and", "7", "of", "C1418516#ent", "<e2>", "(", "PGM", ")", "."], "h": {"id": "C0017759", "name": "C0017759#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418516", "name": "C1418516#ent", "pos": [18, 19]}}
{"token": ["Both", "NPG", "and", "C0301360#ent", "<e1>", "appear", "compatible", "with", "the", "C0067666#ent", "<e2>", "."], "h": {"id": "C0301360", "name": "C0301360#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0067666", "name": "C0067666#ent", "pos": [9, 10]}}
{"token": ["We", "assume", "that", "HGV", "is", "sensitive", "to", "C1415900#ent", "<e1>", ",", "but", "could", "not", "be", "implicated", "in", "C0019159#ent", "<e2>", "or", "liver", "damage"], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [16, 17]}}
{"token": ["C1415900#ent", "<e1>", "resulted", "in", "concentration-dependent", "reduction", "of", "C0019159#ent", "<e2>", "expression", "and", "HAV", "replication", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [7, 8]}}
{"token": ["The", "results", "indicate", "that", "C0029166#ent", "<e1>", "observed", "in", "a", "high", "percentage", "of", "patients", "with", "C0023364#ent", "<e2>", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023364", "name": "C0023364#ent", "pos": [14, 15]}}
{"token": ["We", "studied", "the", "developmental", "expression", "the", "mRNA", "for", "two", "alpha", "granule", "proteins", "fibronectin", "(", "FN", ")", "and", "fibrinogen", "gamma", "chain", "gamma-FIB", ")", ",", "and", "a", "C1414120#ent", "<e1>", "actin", ",", "in", "C1417174#ent", "<e2>", "from", "marrow", "of", "Sprague-Dawley", "rats"], "h": {"id": "C1414120", "name": "C1414120#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1417174", "name": "C1417174#ent", "pos": [30, 31]}}
{"token": ["Other", "compounds", "active", "'", "in", "vitro", "included", "strychnine", ",", "homocarnosine", "and", "some", "(", "e.g.", "clozapine", ",", "thioridazine", ",", "C0031935#ent", "<e1>", ")", "but", "not", "all", "(", "chlorpromazine", ",", "haloperiodol", ")", "C0040615#ent", "<e2>", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [18, 19]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [29, 30]}}
{"token": ["We", "used", "two", "typical", "C0040615#ent", "<e1>", "haloperidol", "and", "C0031935#ent", "<e2>", ",", "and", "two", "atypical", "C0040615#ent", "<e1>", "risperidone", "and", "clozapine", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [8, 9]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [4, 5]}}
{"token": ["C1510471#ent", "<e1>", "more", "common", "than", "C0042880#ent", "<e2>", "however", ",", "all", "vitamin", "K-deficient", "patients", "were", "vitamin", "E", "deficient"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0042880", "name": "C0042880#ent", "pos": [5, 6]}}
{"token": ["The", "integration", "of", "C1416655#ent", "<e1>", "growth", "factor", "transduction", "blocking", "agents", "like", "C1421249#ent", "<e2>", "MAPK", ",", "mTOR", ",", "PI3K", "farnesyl", "transferase", "inhibitors", "hormone", "therapies", "prevent", "or", "treat", "hormone", "resistance"], "h": {"id": "C1416655", "name": "C1416655#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [11, 12]}}
{"token": ["Recent", "studies", "have", "shown", "that", "receptors", "for", "exogenous", "nucleotides", "(", "P2X", "and", "C2936563#ent", "<e1>", "can", "modulate", "macrophage", "production", "of", "C0812246#ent", "<e2>", ",", "IL-1beta", "and", "nitric", "oxide", "NO", ")", "following", "LPS", "exposure", "."], "h": {"id": "C2936563", "name": "C2936563#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [19, 20]}}
{"token": ["Human", "tissue", "kallikreins", "hKs", ")", ",", "which", "are", "encoded", "by", "the", "largest", "contiguous", "cluster", "of", "C1335528#ent", "<e1>", "the", "human", "genome", ",", "are", "secreted", "C2717971#ent", "<e2>", "diverse", "expression", "patterns", "and", "physiological", "roles"], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [23, 24]}}
{"token": ["Also", "found", "in", "complexes", "with", "phoA61", "were", "the", "hsps", ",", "C1947941#ent", "<e1>", "grpE", "(", "but", "no", "groEL", ",", "or", "C1415790#ent", "<e2>", ")", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415790", "name": "C1415790#ent", "pos": [19, 20]}}
{"token": ["In", "clinical", "course", "acute", "pancreatitis", "serum", "C1706169#ent", "<e1>", "was", "maintained", "high", "level", "more", "longer", "than", "serum", "amylase", "C1423849#ent", "<e2>"], "h": {"id": "C1706169", "name": "C1706169#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423849", "name": "C1423849#ent", "pos": [17, 18]}}
{"token": ["Sixty-nine", "patients", "with", "C0032269#ent", "<e1>", "61", "patients", "with", "community-acquired", "pneumonia", "5", "patients", "with", "C0025289#ent", "<e2>", ",", "and", "3", "patients", "with", "pneumonia", "and", "C0025289#ent", "<e2>", ")", "and", "50", "age-matched", "control", "subjects", "included", "."], "h": {"id": "C0032269", "name": "C0032269#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [13, 14]}}
{"token": ["The", "prophylaxis", "of", "C0004099#ent", "<e1>", "inhaled", "formoterol", "12", "micrograms", ")", "was", "compared", "with", "C0001927#ent", "<e2>", "200", "micrograms", ")", "and", "placebo", "in", "12", "patients", "with", "atopic", "asthma"], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [13, 14]}}
{"token": ["The", "magnitude", "and", "duration", "of", "protection", "against", "C0004099#ent", "<e1>", "EIA", ")", "afforded", "by", "C0001927#ent", "<e2>", "and", "the", "new", ",", "long-acting", "beta", "2-agonist", ",", "formoterol", ",", "were", "compared", "in", "a", "double-blind", ",", "placebo-controlled", "crossover", "study"], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "C0001486#ent", "<e1>", "overexpression", "of", "hRORalpha1", "in", "HepG2", "cells", "to", "enhanced", "C1417821#ent", "<e2>", "mRNA", "accumulation", ",", "further", "confirming", "the", "physiological", "importance", "of", "RORalpha1", "in", "the", "regulation", "of", "Rev-erbalpha", "expression", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417821", "name": "C1417821#ent", "pos": [12, 13]}}
{"token": ["By", "using", "specific", "small", "interference", "RNAs", "siRNAs", ")", ",", "we", "demonstrate", "that", "HDAC3", "is", "essential", ",", "whereas", "TBL1", "and", "C1539940#ent", "<e1>", "are", "functionally", "redundant", "but", "essential", "for", "repression", "by", "C0919499#ent", "<e2>"], "h": {"id": "C1539940", "name": "C1539940#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0919499", "name": "C0919499#ent", "pos": [29, 30]}}
{"token": ["The", "latter", "result", "suggested", "that", "C0356622#ent", "<e1>", "mediate", "the", "biological", "actions", "C1537501#ent", "<e2>", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "bradykinin", "does", "not", "directly", "increase", "plasma", "renin", "activity", "and", "that", "C0356622#ent", "<e1>", "may", "participate", "in", "the", "C1537501#ent", "<e2>", "renin", "release", "under", "these", "experimental", "conditions"], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [20, 21]}}
{"token": ["In", "84", "classic", ",", "atypical", ",", "and", "malignant", "meningiomas", "the", "immunohistochemical", "expression", "profile", "P-glycoprotein", "(", "P-gp", ")", ",", "multidrug", "resistance-associated", "protein", "C1537665#ent", "<e1>", ")", ",", "lung", "resistance-related", "protein", "LRP", ")", ",", "metallothionein", ",", "and", "C0256022#ent", "<e2>", "studied", "."], "h": {"id": "C1537665", "name": "C1537665#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0256022", "name": "C0256022#ent", "pos": [34, 35]}}
{"token": ["Cell", "lines", "low", "levels", "of", "C1537665#ent", "<e1>", "had", "lower", "levels", "of", "C0256022#ent", "<e2>", "while", "those", "with", "high", "levels", "of", "C1537665#ent", "<e1>", "maintained", "higher", "levels", "of", "C0256022#ent", "<e2>"], "h": {"id": "C1537665", "name": "C1537665#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0256022", "name": "C0256022#ent", "pos": [11, 12]}}
{"token": ["Most", "likely", ",", "the", "presence", "of", "this", "C2917660#ent", "<e1>", "required", "for", "adopting", "of", "the", "proper", "conformation", "for", "C0029904#ent", "<e2>", "binding", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [17, 18]}}
{"token": ["In", "order", "to", "elucidate", "the", "mechanisms", "of", "the", "C2917660#ent", "<e1>", ",", "studies", "with", "phloridzin", ",", "C0029904#ent", "<e2>", ",", "iodoacetate", ",", "cytochalasin", "B", "and", "Na+-deficiency", "were", "performed", "with", "the", "most", "effective", "C2917660#ent", "<e1>", "L-isoleucine", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [15, 16]}}
{"token": ["Members", "of", "the", "APOBEC", "(", "C1528545#ent", "<e1>", "family", "of", "C0010723#ent", "<e2>", "inhibit", "host", "cell", "genome", "invasion", "exogenous", "retroviruses", "and", "endogenous", "retrotransposons", "."], "h": {"id": "C1528545", "name": "C1528545#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0010723", "name": "C0010723#ent", "pos": [9, 10]}}
{"token": ["Inhibition", "of", "C0032405#ent", "<e1>", "the", "addition", "of", "3-aminobenzamide", "before", "irradiation", "increased", "both", "cell", "killing", "C0025677#ent", "<e2>", "resistance", "."], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "C1723257#ent", "<e1>", "could", "be", "prevented", "by", "exogenous", "C1413138#ent", "<e2>", "(", "CAT", ")", ",", "but", "not", "superoxide", "dismutase", "SOD", ")", ",", "in", "the", "cell", "suspensions"], "h": {"id": "C1723257", "name": "C1723257#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [10, 11]}}
{"token": ["Two", "enzymes", "are", "capable", "of", "C0033993#ent", "<e1>", "trehalose", ":", "a", "neutral", "trehalase", "C3811763#ent", "<e2>", ")", "and", "an", "acidic", "trehalase", "ATH1", ")", "."], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811763", "name": "C3811763#ent", "pos": [12, 13]}}
{"token": ["Patients", "with", "the", "C0039082#ent", "<e1>", "of", "mitochondrial", "encephalopathy", "lactic", "acidosis", "and", "strokelike", "episodes", "C0162671#ent", "<e2>", ")", "may", "rarely", "present", "with", "complex", "partial", "status", "epilepticus", "CPSE", ")", "at", "clinical", "onset"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0162671", "name": "C0162671#ent", "pos": [13, 14]}}
{"token": ["An", "intermediate", "phase", "characterized", "by", "total", "release", "of", "C0672045#ent", "<e1>", "most", "of", "the", "C0017755#ent", "<e2>", ",", "marker", "enzymes", "for", "the", "mitochondrial", "intermembrane", "space", "the", "endoplasmic", "reticulum", "respectively", "."], "h": {"id": "C0672045", "name": "C0672045#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [13, 14]}}
{"token": ["This", "group", "includes", "rheumatoid", "arthritis", "the", "often", "underdiagnosed", "C0949691#ent", "<e1>", "and", ",", "less", "commonly", ",", "crystalline", "deposit", "disorders", "and", "C0041785#ent", "<e2>"], "h": {"id": "C0949691", "name": "C0949691#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041785", "name": "C0041785#ent", "pos": [19, 20]}}
{"token": ["C0249586#ent", "<e1>", "Cdk5", ")", "is", "a", "C0084209#ent", "<e2>", "is", "most", "active", "in", "the", "CNS", ",", "and", "has", "been", "implicated", "as", "a", "contributing", "factor", "in", "certain", "neurodegenerative", "diseases"], "h": {"id": "C0249586", "name": "C0249586#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0084209", "name": "C0084209#ent", "pos": [6, 7]}}
{"token": ["Long-term", "functional", "and", "oncological", "results", "are", "maturing", "but", "early", "reports", "of", "positive", "surgical", "margin", "and", "freedom", "from", "C1366489#ent", "<e1>", "PSA", ")", "recurrence", "rates", "after", "C1417509#ent", "<e2>", "are", "encouraging", "."], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417509", "name": "C1417509#ent", "pos": [24, 25]}}
{"token": ["Total", "biliary", "phospholipid", "secretions", "in", "patients", "with", "C0267963#ent", "<e1>", "common", "bile", "duct", "stenosis", "significantly", "lower", "than", "those", "in", "patients", "with", "C0267963#ent", "<e1>", "and", "C0267963#ent", "<e1>", "common", "bile", "duct", "stenosis"], "h": {"id": "C0267963", "name": "C0267963#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0267963", "name": "C0267963#ent", "pos": [7, 8]}}
{"token": ["C0015674#ent", "<e1>", "patients", "with", "low", "mental", "fatigue", "performance", "comparable", "to", "C0015672#ent", "<e2>", "subjects", "on", "all", "tests", "of", "the", "CANTAB", "battery"], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0015672", "name": "C0015672#ent", "pos": [10, 11]}}
{"token": ["The", "regenerating", "process", "in", "tissue", "around", "C0017563#ent", "<e1>", "PDTs", ")", "and", "C0040435#ent", "<e2>", "NDTs", ")", "was", "studied", "with", "clinical", "and", "histological", "analysis", "flap", "surgery"], "h": {"id": "C0017563", "name": "C0017563#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0040435", "name": "C0040435#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", "to", "C4", ",", "however", ",", "C4283853#ent", "<e1>", "is", "regulated", "by", "C3536949#ent", "<e2>", "."], "h": {"id": "C4283853", "name": "C4283853#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [12, 13]}}
{"token": ["Because", "initial", "studies", "showed", "a", "functional", "deficiency", "C1", "esterase", "inhibitor", "C4283853#ent", "<e1>", ",", "he", "was", "treated", "with", "danazol", ",", "an", "attenuated", "C3536949#ent", "<e2>", "that", "has", "proven", "to", "be", "effective", "in", "the", "treatment", "of", "angioedema", "associated", "with", "C1", "esterase", "inhibitor", "deficiency"], "h": {"id": "C4283853", "name": "C4283853#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "it", "seems", "that", "the", "5-HT", "antagonism", "does", "not", "contribute", "to", "the", "therapeutic", "effect", "C0014710#ent", "<e1>", "during", "the", "C0149931#ent", "<e2>", "attack", "."], "h": {"id": "C0014710", "name": "C0014710#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [19, 20]}}
{"token": ["Sumatriptan", "must", "not", "be", "given", "together", "with", "vasoconstrictive", "substances", "e.g.", ",", "C0014710#ent", "<e1>", ",", "or", "with", "C0149931#ent", "<e2>", "prophylactics", "with", "similar", "properties", ",", "e.g.", ",", "methysergide", "."], "h": {"id": "C0014710", "name": "C0014710#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [16, 17]}}
{"token": ["The", "responses", "to", "mATP", "were", "not", "modified", "by", "pretreatment", "with", "the", "C0242889#ent", "<e1>", "phentolamine", "and", "propranolol", "or", "the", "purinoceptor", "antagonist", "C0038880#ent", "<e2>", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [20, 21]}}
{"token": ["Reserpine", "in", "doses", "of", "5", "-", "10", "mg/kg", "C3273618#ent", "<e1>", ",", "given", "alone", "or", "in", "combination", "with", "C0051427#ent", "<e2>", "(", "alpha", "MT", ",", "250", "mg/kg", "ip", ")", ",", "induced", "rigidity", "."], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0051427", "name": "C0051427#ent", "pos": [17, 18]}}
{"token": ["Now", "it", "is", "used", "to", "treat", "many", "C4025230#ent", "<e1>", "such", "as", "lumbar", "discogenic", "pain", "C0838765#ent", "<e2>", "lumbar", "spondylolisthesis", "so", "on", "."], "h": {"id": "C4025230", "name": "C4025230#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0838765", "name": "C0838765#ent", "pos": [14, 15]}}
{"token": ["Acidic", "fibroblast", "growth", "factor", "C1522455#ent", "<e1>", ")", ",", "also", "known", "as", "C1333536#ent", "<e2>", "is", "a", "mitogen", "for", "a", "variety", "of", "mesoderm-", "and", "neuroectoderm-derived", "cells", "."], "h": {"id": "C1522455", "name": "C1522455#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333536", "name": "C1333536#ent", "pos": [11, 12]}}
{"token": ["Phenibut", "(", "3-phenyl-4-aminobutyric", "acid", ")", "is", "a", "C0242898#ent", "<e1>", "mimetic", "drug", "which", "is", "used", "clinically", "as", "a", "mood", "elevator", "C0040614#ent", "<e2>", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040614", "name": "C0040614#ent", "pos": [19, 20]}}
{"token": ["The", "C0017337#ent", "<e1>", "responsible", "for", "C4084746#ent", "<e2>", "is", "the", "human", "homologue", "of", "the", "mouse", "underwhite", "uw", ")", "gene", ",", "which", "encodes", "the", "membrane-associated", "transporter", "protein", "MATP", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4084746", "name": "C4084746#ent", "pos": [5, 6]}}
{"token": ["Inhibiting", "the", "activity", "of", "these", "C2350349#ent", "<e1>", "decreased", "growth", "factor", "depletion", ",", "suggesting", "that", "these", "C3541394#ent", "<e2>", "play", "an", "important", "role", "in", "the", "control", "of", "extracellular", "growth", "factor", "."], "h": {"id": "C2350349", "name": "C2350349#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}}
{"token": ["C0021669#ent", "<e1>", "IDE", ")", "is", "a", "C1334706#ent", "<e2>", "which", "degrades", "insulin", "and", "terminates", "its", "action", "."], "h": {"id": "C0021669", "name": "C0021669#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [6, 7]}}
{"token": ["Several", "putative", "Escherichia", "coli", "pseudouridine", "Psi", ")", "C0132555#ent", "<e1>", "have", "been", "identified", "by", "iterative", "searching", "of", "genomic", "databases", "C0341703#ent", "<e2>", "homologous", "to", "known", "Psi", "synthases", "Gustafsson", "et", "al.", "(", "1996", ")", "Nucleic", "Acids", "Res", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0341703", "name": "C0341703#ent", "pos": [18, 19]}}
{"token": ["LAM", "cell", "proliferation", "obstruct", "bronchioles", ",", "lymph", "vessels", "venules", "that", "lead", "to", "airflow", "obstruction", ",", "formation", "of", "C0546483#ent", "<e1>", "bullas", "and", "pneumothoraces", ",", "chylothorax", ",", "chylous", "ascites", "C0019114#ent", "<e2>", "and", "hemoptysis", "."], "h": {"id": "C0546483", "name": "C0546483#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0019114", "name": "C0019114#ent", "pos": [27, 28]}}
{"token": ["We", "determined", "the", "incidence", "of", "immune", "complex", "increases", ",", "the", "nature", "of", "immune", "complexes", "and", "the", "correlation", "between", "the", "immune", "complex", "level", "and", "C0042164#ent", "<e1>", "in", "patients", "with", "chronic", "iridocyclitis", "C0030343#ent", "<e2>"], "h": {"id": "C0042164", "name": "C0042164#ent", "pos": [23, 24]}, "relation": "nichd_parent_of", "t": {"id": "C0030343", "name": "C0030343#ent", "pos": [30, 31]}}
{"token": ["To", "compare", "ketamine", "hydrochloride", "C2984561#ent", "<e1>", ")", "with", "combined", "meperidine", "hydrochloride", "C0546876#ent", "<e2>", "and", "chlorpromazine", "hydrochloride", "MPC", ")", "for", "pediatric", "emergency", "department", "sedation", "respect", "to", "onset", ",", "duration", ",", "and", "efficacy", "."], "h": {"id": "C2984561", "name": "C2984561#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0546876", "name": "C0546876#ent", "pos": [11, 12]}}
{"token": ["The", "purified", "enzyme", "was", "devoid", "of", "C0051581#ent", "<e1>", "and", "common", "exo-", "and", "C0030946#ent", "<e2>", "contamination", "."], "h": {"id": "C0051581", "name": "C0051581#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [12, 13]}}
{"token": ["It", "is", "suggested", "that", "PR1-lysozyme", "should", "be", "classified", "as", "a", "glycosidase", ",", "rather", "than", "an", "C0051581#ent", "<e1>", "or", "an", "C0030946#ent", "<e2>", "."], "h": {"id": "C0051581", "name": "C0051581#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [19, 20]}}
{"token": ["We", "have", "used", "a", "full", "length", "cDNA", "clone", "to", "determine", "the", "chromosomal", "location", "the", "C0079429#ent", "<e1>", "encoding", "human", "C0029278#ent", "<e2>", "OAT", ")", ",", "a", "mitochondrial", "matrix", "enzyme"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029278", "name": "C0029278#ent", "pos": [18, 19]}}
{"token": ["Using", "purified", "C0034861#ent", "<e1>", "we", "show", "that", "AZI", "(", "which", "has", "no", "C1422630#ent", "<e2>", "activity", ")", "can", "release", "enzymically", "active", "C1422630#ent", "<e2>", "from", "antizyme", "suppression", "in", "vitro"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422630", "name": "C1422630#ent", "pos": [12, 13]}}
{"token": ["The", "examination", "of", "transcript", "levels", "showed", "that", "the", "general", "flavonoid", "pathway", "regulators", "C1421944#ent", "<e1>", "and", "PAP2", "were", "up-regulated", "in", "response", "to", "nitrogen", "deficiency", "C1883559#ent", "<e2>", "well", "as", "pap1D", "plants", "."], "h": {"id": "C1421944", "name": "C1421944#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [23, 24]}}
{"token": ["The", "carboxyl-terminal", "half", "C1334880#ent", "<e1>", "displays", "sequence", "homology", "to", "the", "C1333331#ent", "<e2>", "the", "low-density", "lipoprotein", "receptor", "and", "in", "both", "genes", "this", "region", "is", "encoded", "by", "eight", "exons", "."], "h": {"id": "C1334880", "name": "C1334880#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333331", "name": "C1333331#ent", "pos": [10, 11]}}
{"token": ["Secondary", "electron", "transfer", "added", "electron", "donors", "to", "the", "oxidized", "tryptophan", "radical", "with", "rate", "constants", "ranging", "from", "10(4", ")", "(", "C0012789#ent", "<e1>", ")", "to", "4", "x", "10(6", ")", "M-1", "s-1", "(", "C0033501#ent", "<e2>", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0033501", "name": "C0033501#ent", "pos": [30, 31]}}
{"token": ["Complexing", "with", "the", "C1414528#ent", "<e1>", "'", "resulted", "in", "significant", "stabilization", "of", "C0006217#ent", "<e2>", "against", "thermal", "inactivation", "alkaline", "pH."], "h": {"id": "C1414528", "name": "C1414528#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006217", "name": "C0006217#ent", "pos": [11, 12]}}
{"token": ["The", "enzyme", "hydrolyzed", "3H-labeled", "alpha-casein", "into", "C0718099#ent", "<e1>", "acid-soluble", "forms", "in", "C0041175#ent", "<e2>", "Mg2+", "ATP", "."], "h": {"id": "C0718099", "name": "C0718099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041175", "name": "C0041175#ent", "pos": [11, 12]}}
{"token": ["This", "3.5", "kb", "DNA", "fragment", "found", "to", "contain", "a", "sequence", "of", "a", "C0079429#ent", "<e1>", "encoding", "a", "protein", "with", "significant", "homology", "to", "the", "dihydrolipoamide", "succinyltransferase", "C0302362#ent", "<e2>", "sucB", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0302362", "name": "C0302362#ent", "pos": [24, 25]}}
{"token": ["C3150926#ent", "<e1>", "a", "rare", "disorder", "characterized", "by", "mild", "to", "moderate", "C0002871#ent", "<e2>", ",", "ineffective", "erythropoiesis", ",", "and", "morphologic", "abnormalities", "mature", "red", "blood", "cells", "their", "precursors", "."], "h": {"id": "C3150926", "name": "C3150926#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [10, 11]}}
{"token": ["The", "analytical", "procedure", "been", "applied", "to", "a", "pharmacokinetic", "study", "C0022322#ent", "<e1>", "in", "healthy", "volunteers", "to", "the", "analysis", "of", "plasma", "specimens", "patients", "with", "C0038463#ent", "<e2>"], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [22, 23]}}
{"token": ["We", "assessed", "the", "efficacy", "and", "adverse", "effects", "C0022322#ent", "<e1>", "for", "the", "treatment", "of", "C0038463#ent", "<e2>"], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [13, 14]}}
{"token": ["The", "ability", "to", "achieve", "adequate", "levels", "of", "C0022322#ent", "<e1>", "after", "oral", "administration", "patients", "with", "C0038463#ent", "<e2>", "be", "impaired", ",", "highlighting", "the", "need", "for", "alternative", "routes", "of", "administration", "of", "C0022322#ent", "<e1>", "in", "these", "patients", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [14, 15]}}
{"token": ["SOCS-2", "was", "shown", "to", "suppress", "the", "inhibitory", "effect", "of", "SOCS-1", "by", "restoring", "C1334291#ent", "<e1>", "but", "did", "not", "affect", "the", "inhibitory", "effect", "of", "C3275257#ent", "<e2>", "on", "PRL", "signaling", "."], "h": {"id": "C1334291", "name": "C1334291#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3275257", "name": "C3275257#ent", "pos": [22, 23]}}
{"token": ["Because", "mitochondrial", "ATPase", "plays", "an", "important", "role", "in", "C1705556#ent", "<e1>", "synthesis", ",", "mutations", "affecting", "ATPase", "6", "undoubtedly", "cause", "C0029896#ent", "<e2>"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [18, 19]}}
{"token": ["TPx", "C4277608#ent", "<e1>", ",", "termed", "peroxiredoxin", "(", "C1422198#ent", "<e2>", ")", ",", "have", "also", "been", "identified", "and", "include", "several", "proteins", ",", "designated", "1-Cys", "Prx", ",", "that", "contain", "only", "one", "conserved", "cysteine", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1422198", "name": "C1422198#ent", "pos": [7, 8]}}
{"token": ["The", "camC", "gene", "specifies", "cytochrome", "P-450cam", "and", "C1412379#ent", "<e1>", "specifies", "the", "5-exo-alcohol", "C0030016#ent", "<e2>", "."], "h": {"id": "C1412379", "name": "C1412379#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [12, 13]}}
{"token": ["The", "iviVII", "gene", "of", "Vibrio", "cholerae", "previously", "identified", "by", "a", "screen", "for", "C0017337#ent", "<e1>", "induced", "during", "C1698036#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1698036", "name": "C1698036#ent", "pos": [16, 17]}}
{"token": ["The", "efficacy", "of", "treatment", "with", "the", "antioxidant", "agents", "butylated", "hydroxyanisole", "C0051235#ent", "<e1>", "and", "N-acetylcysteine", ",", "in", "attenuation", "of", "C0034069#ent", "<e2>", "also", "investigated", "."], "h": {"id": "C0051235", "name": "C0051235#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [18, 19]}}
{"token": ["Prevalence", "of", "C0004057#ent", "<e1>", "was", "not", "significantly", "different", "in", "stroke", ",", "C0007787#ent", "<e2>", "and", "peripheral", "emboli", "subgroups", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [2, 3]}, "relation": "may_prevent", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [11, 12]}}
{"token": ["We", "evaluated", "whether", "the", "risk", "of", "stroke", "depends", "on", "C0004057#ent", "<e1>", "dose", "in", "patients", "with", "a", "previous", "transient", "C0007787#ent", "<e2>", "stroke", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [9, 10]}, "relation": "may_prevent", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [18, 19]}}
{"token": ["Elevated", "basal", "plasma", "C1704793#ent", "<e1>", "levels", "and", "suppression", "of", "C3536949#ent", "<e2>", "and", "C1704793#ent", "<e1>", "levels", "by", "dexamethasone", "strongly", "suggested", "CAH", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [9, 10]}}
{"token": ["Incubation", "of", "testicular", "tissue", "C1704793#ent", "<e1>", "did", "not", "result", "in", "a", "significant", "change", "in", "C3536949#ent", "<e2>", "production", "as", "compared", "to", "the", "controls", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [14, 15]}}
{"token": ["Plasma", "of", "patients", "with", "AMI", "contained", "more", "C0017860#ent", "<e1>", "and", "lecithin", "but", "less", "C3160060#ent", "<e2>", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3160060", "name": "C3160060#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "temperature", "and", "various", "C0017860#ent", "<e1>", "to", "modulate", "the", "ability", "of", "C3160060#ent", "<e2>", "and", "fatty", "acid", "promote", "high", "phospholipase", "A2", "activity", "was", "studied", "using", "dipalmitoylphosphatidylcholine", "large", "unilamellar", "vesicles", "substrate", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3160060", "name": "C3160060#ent", "pos": [13, 14]}}
{"token": ["We", "have", "studied", "the", "induction", "of", "NGFI-B", "and", "C1417838#ent", "<e1>", "and", "mRNAs", "by", "the", "peptide", "hormones", "ACTH", ",", "C2698414#ent", "<e2>", ",", "IGF", ",", "FGF", ",", "and", "by", "KCl", "depolarization", "in", "cultured", "bovine", "adrenocortical", "cells"], "h": {"id": "C1417838", "name": "C1417838#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [18, 19]}}
{"token": ["The", "results", "show", "that", "NGFI-B", "and", "C1417838#ent", "<e1>", "mRNAs", "are", "differentially", "regulated", "by", "ACTH", "and", "C2698414#ent", "<e2>", "."], "h": {"id": "C1417838", "name": "C1417838#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [15, 16]}}
{"token": ["Positional", "cloning", "characterization", "of", "the", "C0694883#ent", "<e1>", "mutations", "will", "clarify", "the", "genetics", "of", "the", "C1848862#ent", "<e2>", "and", "the", "implication", "of", "the", "gene(s", ")", "in", "the", "predisposition", "to", "neoplasias", "."], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [14, 15]}}
{"token": ["Such", "mutants", "were", "found", "to", "be", "C0907533#ent", "<e1>", "for", "the", "synthesis", "of", "C0020809#ent", "<e2>", "were", "thus", "capable", "of", "oxidizing", "6-deoxy", "L-talitol", "to", "L-fuculose", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020809", "name": "C0020809#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "report", "C0384782#ent", "<e1>", "length-dependent", "enhancement", "of", "peak", "C0022614#ent", "<e2>", "current", "density", "by", "mhtt", "in", "cultured", "MSNs", ",", "but", "not", "cortical", "neurons", ",", "from", "the", "yeast", "artificial", "chromosome", "YAC", ")", "transgenic", "HD", "mouse", "model"], "h": {"id": "C0384782", "name": "C0384782#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [9, 10]}}
{"token": ["All", "compounds", "produced", "a", "C0384782#ent", "<e1>", "length-dependent", "increase", "in", "apoptosis", ",", "but", "C0022614#ent", "<e2>", "produced", "the", "largest", "potentiation", "in", "apoptosis", "of", "YAC72", "and", "YAC128", "versus", "YAC18", "MSNs", "."], "h": {"id": "C0384782", "name": "C0384782#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [12, 13]}}
{"token": ["These", "studies", "reveal", "an", "essential", "and", "redundant", "role", "for", "C2987024#ent", "<e1>", "enzymes", "in", "controlling", "class", "II", "C3539637#ent", "<e2>", "in", "B", "lymphocytes", "suggest", "that", "PKD", "serine", "kinases", "a", "critical", "link", "between", "the", "BCR", "and", "epigenetic", "control", "chromatin", "."], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539637", "name": "C3539637#ent", "pos": [16, 17]}}
{"token": ["Selected", "modalities", "with", "promising", "results", "include", "total", "hip", "replacement", "intractable", "pagetic", "arthritis", "the", "hip", ",", "proximal", "tibial", "osteotomy", "C0239377#ent", "<e1>", "malalignment", "of", "the", "knees", ",", "total", "knee", "replacement", "intractable", "C0003864#ent", "<e2>", "of", "the", "knee", ",", "and", "internal", "fixation", "pathological", "fracture"], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [29, 30]}}
{"token": ["Congenital", "etiologies", ":", "C0035067#ent", "<e1>", "renal", "artery", "hypoplasia", "abdominal", "aortic", "atresia", "coarctation", "of", "the", "aorta", ",", "kidney", "cystic", "disease", "C0022658#ent", "<e2>"], "h": {"id": "C0035067", "name": "C0035067#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "the", "highly", "selective", "expression", "of", "C1825293#ent", "<e1>", "in", "leukocytes", ",", "particularly", "C0064833#ent", "<e2>", "suggests", "a", "role", "in", "the", "recruitment", "of", "these", "cell", "populations", "sites", "of", "bacterial", "infection"], "h": {"id": "C1825293", "name": "C1825293#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [14, 15]}}
{"token": ["Preterm", "children", "C1418479#ent", "<e1>", "and", "with", "peri-", "and", "postnatal", "complications", "such", "as", "pneumothorax", "or", "intracerebral", "haemorrhage", "increased", "concentrations", "in", "plasma", "of", "the", "C1332656#ent", "<e2>", "C5a", "compared", "with", "preterm", "children", "C1418479#ent", "<e1>", "without", "these", "complications", "."], "h": {"id": "C1332656", "name": "C1332656#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1418479", "name": "C1418479#ent", "pos": [2, 3]}}
{"token": ["To", "compare", "the", "efficacy", "of", "C0081876#ent", "<e1>", "and", "esomeprazole", "for", "the", "treatment", "of", "C0017168#ent", "<e2>", "(", "GERD-", ")", "related", "symptoms", "."], "h": {"id": "C0081876", "name": "C0081876#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [13, 14]}}
{"token": ["This", "is", "our", "final", "report", "on", "the", "clinical", "effectiveness", "safety", "of", "long-term", "C0081876#ent", "<e1>", "in", "patients", "with", "severe", "peptic", "ulcer", "C0017168#ent", "<e2>", "continuous", "treatment", "up", "to", "5", "years", "."], "h": {"id": "C0081876", "name": "C0081876#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [20, 21]}}
{"token": ["These", "polypeptides", "showed", "considerable", "similarity", "to", "rat", "C0054521#ent", "<e1>", "more", "than", "70", "%", "of", "the", "C3539946#ent", "<e2>", "identical", "."], "h": {"id": "C0054521", "name": "C0054521#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [15, 16]}}
{"token": ["Amplitude", ",", "habituation", "and", "prepulse", "inhibition", "PPI", ")", "of", "the", "acoustic", "startle", "response", "C1707081#ent", "<e1>", ")", "in", "rodents", "and", "humans", "are", "sensitive", "to", "C0033978#ent", "<e2>"], "h": {"id": "C1707081", "name": "C1707081#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [23, 24]}}
{"token": ["We", "have", "re-screened", "the", "C1417679#ent", "<e1>", "for", "the", "5-HT1A", ",", "5-HT2A", ",", "C3889121#ent", "<e2>", ",", "and", "5-HT7", "serotonin", "receptors", "genetic", "variants", "a", "large", "African-American", "and", "Caucasian-American", "population", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889121", "name": "C3889121#ent", "pos": [12, 13]}}
{"token": ["The", "pharmacological", "effects", "cabergoline", ",", "a", "novel", "ergot", "alkaloid", "against", "C0030567#ent", "<e1>", "were", "assessed", "by", "comparing", "its", "effects", "with", "of", "bromocriptine", "and", "C0031007#ent", "<e2>", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0031007", "name": "C0031007#ent", "pos": [22, 23]}}
{"token": ["We", "emphasize", "that", "C0030567#ent", "<e1>", "can", "be", "sufficiently", "treated", "with", "C0031007#ent", "<e2>", "and", "L-dopa", "and", "that", "surgical", "treatment", "be", "minimized", "unless", "there", "is", "no", "alternative", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031007", "name": "C0031007#ent", "pos": [10, 11]}}
{"token": ["Bacterial", "vaginosis", "trichomoniasis", "and", "C0006840#ent", "<e1>", "are", "the", "most", "common", "C0729552#ent", "<e2>"], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0729552", "name": "C0729552#ent", "pos": [10, 11]}}
{"token": ["The", "authors", "conclude", "that", "intravenous", "C0033429#ent", "<e1>", "is", "generally", "inadequate", "for", "rate", "control", "C0004238#ent", "<e2>", ",", "especially", "in", "the", "upright", "position"], "h": {"id": "C0033429", "name": "C0033429#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [13, 14]}}
{"token": ["C1825552#ent", "<e1>", ",", "a", "member", "of", "the", "mammalian", "C1258300#ent", "<e2>", "has", "a", "highly", "conserved", "protease", "domain", "by", "a", "PDZ", "domain"], "h": {"id": "C1825552", "name": "C1825552#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1258300", "name": "C1258300#ent", "pos": [8, 9]}}
{"token": ["Differential", "gene", "expression", "cell", "lines", "from", "a", "malignant", "melanoma", "its", "autologous", "lymph", "node", "metastasis", "cDNA", "arrays", "down-regulation", "of", "C1825552#ent", "<e1>", ",", "a", "gene", "encoding", "the", "serine", "protease", "C1258300#ent", "<e2>", ",", "a", "homolog", "of", "the", "Escherichia", "coli", "protease", "HtrA", ",", "in", "the", "metastatic", "line"], "h": {"id": "C1825552", "name": "C1825552#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1258300", "name": "C1258300#ent", "pos": [27, 28]}}
{"token": ["Phosphorylation", "of", "C0669365#ent", "<e1>", "ACE", "cells", "stimulated", "by", "C1425526#ent", "<e2>", "with", "a", "time", "course", "correlated", "to", "the", "Akt", "phosphorylation", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1425526", "name": "C1425526#ent", "pos": [8, 9]}}
{"token": ["significantly", "attenuated", "the", "penile", "erection", "induced", "by", "C0028362#ent", "<e1>", "and", "apomorphine", ",", "but", "scarcely", "affected", "that", "induced", "by", "C0770456#ent", "<e2>", "."], "h": {"id": "C0028362", "name": "C0028362#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0770456", "name": "C0770456#ent", "pos": [18, 19]}}
{"token": ["The", "potency", "of", "the", "inhibitory", "action", "of", "C2981725#ent", "<e1>", "was", "less", "than", "that", "of", "C0032912#ent", "<e2>", "in", "all", "preparations", "used", "."], "h": {"id": "C2981725", "name": "C2981725#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", "the", "T", "allele", "the", "third", "position", "of", "codon", "96", "in", "the", "C0164371#ent", "<e1>", "be", "associated", "with", "persistent", "C0019163#ent", "<e2>", "infection", "."], "h": {"id": "C0164371", "name": "C0164371#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [19, 20]}}
{"token": ["However", ",", "the", "treatment", "of", "the", "disease", "presents", "certain", "difficulties", "as", "the", "usual", "known", "drugs", "such", "as", "C0282162#ent", "<e1>", "praziquantel", "do", "not", "cure", "C0015655#ent", "<e2>", "using", "a", "single", "dose"], "h": {"id": "C0282162", "name": "C0282162#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0015655", "name": "C0015655#ent", "pos": [23, 24]}}
{"token": ["The", "deduced", "protein", "(", "AcSrc1", ")", "with", "the", "highest", "identity", "of", "about", "60", "%", "to", "mammalian", "C0282625#ent", "<e1>", "the", "characteristic", "features", "of", "the", "C0038085#ent", "<e2>"], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [23, 24]}}
{"token": ["The", "autoinhibited", "C0282625#ent", "<e1>", "reveal", "a", "mode", "of", "domain", "assembly", "by", "other", "tyrosine", "kinases", "the", "C0038085#ent", "<e2>", "including", "Abl", "and", "likely", "Tec", "family", "kinases"], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [15, 16]}}
{"token": ["Apigenin-treated", "5L", "and", "BP8", "cultures", "primarily", "arrested", "in", "G(2)/M.", "The", "AHR-containing", "murine", "hepatoma", "cell", "line", "C3538764#ent", "<e1>", "arrested", "following", "exposure", "to", "AHR", "C2987634#ent", "<e2>", "concentrations", "of", "flavone", "and", "alpha-naphthoflavone", ",", "but", "not", "TCDD", "."], "h": {"id": "C3538764", "name": "C3538764#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [22, 23]}}
{"token": ["The", "rat", "C1420590#ent", "<e1>", "TAT", ")", "gene", "is", "a", "liver-specific", "and", "C1176140#ent", "<e2>"], "h": {"id": "C1420590", "name": "C1420590#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [11, 12]}}
{"token": ["Mice", "receiving", "Li", "prior", "to", "C0631180#ent", "<e1>", "did", "not", "develop", "C0040034#ent", "<e2>", "and", "their", "absolute", "granulocyte", "counts", "recovered", "more", "rapidly", "when", "compared", "to", "CTX-PBS", "controls", "."], "h": {"id": "C0631180", "name": "C0631180#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [10, 11]}}
{"token": ["These", "data", "suggested", "that", "C1704669#ent", "<e1>", "might", "be", "involved", "in", "the", "induction", "of", "pulmonary", "damage", "C0175697#ent", "<e2>", "."], "h": {"id": "C1704669", "name": "C1704669#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [15, 16]}}
{"token": ["The", "authors", "then", "compared", "these", "quantitative", "data", "for", "C0127400#ent", "<e1>", "with", "objective", "nasal", "findings", "the", "number", "of", "sneezes", "passive", "anterior", "rhinomanometry", "C4283882#ent", "<e2>", ")", "and", "nasal", "inspiratory", "peak", "flow"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283882", "name": "C4283882#ent", "pos": [21, 22]}}
{"token": ["However", ",", "when", "TRPV1", "containing", "nerve", "endings", "were", "initially", "activated", "by", "RTX", ",", "the", "release", "of", "C0127400#ent", "<e1>", "may", "have", "affected", "C4283882#ent", "<e2>", "discharges", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4283882", "name": "C4283882#ent", "pos": [21, 22]}}
{"token": ["A23187", "caused", "an", "increase", "of", "C0061147#ent", "<e1>", "secretion", "and", "addition", "of", "C0078956#ent", "<e2>", "together", "with", "A23187", "revealed", "an", "additive", "effect", "the", "C0061147#ent", "<e1>", "secretion", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0061147", "name": "C0061147#ent", "pos": [5, 6]}}
{"token": ["PLA(2)", "activated", "by", "phospholipase-A(2)-activating", "protein", "(", "C3812647#ent", "<e1>", ")", "and", "LO", "by", "C2936832#ent", "<e2>", "FLAP", ")", "."], "h": {"id": "C3812647", "name": "C3812647#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936832", "name": "C2936832#ent", "pos": [12, 13]}}
{"token": ["Although", "intravenous", "immunoglobulin", "G", "IVIG", ")", "therapy", "has", "been", "reported", "in", "hyperbilirubinemia", "of", "C0014761#ent", "<e1>", "its", "use", "in", "C0270202#ent", "<e2>", "been", "reported", "in", "only", "a", "few", "studies", "."], "h": {"id": "C0014761", "name": "C0014761#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0270202", "name": "C0270202#ent", "pos": [18, 19]}}
{"token": ["HbCO", "measurement", "may", "facilitate", "the", "early", "diagnosis", "C0014761#ent", "<e1>", "the", "prediction", "of", "jaundice", "caused", "by", "C0270202#ent", "<e2>"], "h": {"id": "C0014761", "name": "C0014761#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0270202", "name": "C0270202#ent", "pos": [15, 16]}}
{"token": ["Dermatoses", "like", "C0221244#ent", "<e1>", "lichen", "planus", "and", "some", "infections", "and", "infestations", "like", "scabies", ",", "C0002992#ent", "<e2>", "human", "papilloma", "virus", "infection", "molluscum", "contagiosum", "dermatophytosis", "can", "not", "be", "considered", "as", "AIDS-defining", "illnesses", "per", "se", "."], "h": {"id": "C0221244", "name": "C0221244#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002992", "name": "C0002992#ent", "pos": [14, 15]}}
{"token": ["On", "the", "other", "hand", ",", "patients", "with", "3-hydroxy-3-methyl", "glutaryl-CoA", "lyase", "deficiency", "holocarboxylase", "synthetase", "deficiency", "medium", "or", "long-chain", "acyl-CoA", "dehydrogenase", "deficiency", "neonatal", "onset", "3-methylglutaconic", "aciduria", "C0268595#ent", "<e1>", "and", "disorders", "of", "fructose", "metabolism", "invariably", "had", "moderate-to-severe", "C0020615#ent", "<e2>", "associated", "with", "metabolic", "crisis"], "h": {"id": "C0268595", "name": "C0268595#ent", "pos": [24, 25]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [34, 35]}}
{"token": ["However", ",", "concomitant", "administrations", "of", "antinociceptively", "inactive", "doses", "of", "C0015846#ent", "<e1>", ",", "clonidine", "or", "bethanechol", "with", "C0068700#ent", "<e2>", "elicited", "significant", "suppression", "of", "the", "thermonociceptive", "response", "."], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0068700", "name": "C0068700#ent", "pos": [16, 17]}}
{"token": ["Previously", ",", "we", "isolated", "a", "human", "homologue", "of", "C1425416#ent", "<e1>", "(", "hRAD18", ")", "and", "showed", "that", "human", "cells", "overexpressing", "C1434353#ent", "<e2>", "a", "mutation", "in", "the", "RING", "finger", "motif", "defective", "in", "postreplication", "repair"], "h": {"id": "C1425416", "name": "C1425416#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1434353", "name": "C1434353#ent", "pos": [19, 20]}}
{"token": ["Preincubation", "of", "human", "liver", "microsomes", "with", "C0006863#ent", "<e1>", "selectively", "decreased", "the", "formation", "of", "C0039663#ent", "<e2>", "metabolites", "catalyzed", "by", "cytochrome", "P4503A", "by", "60", "%", "but", "had", "no", "effect", "on", "P4502C9-catalyzed", "metabolites", "."], "h": {"id": "C0006863", "name": "C0006863#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039663", "name": "C0039663#ent", "pos": [13, 14]}}
{"token": ["We", "have", "investigated", "phosphorylation", "of", "human", "C0909712#ent", "<e1>", "NDPK", ")", "and", "of", "C1334043#ent", "<e2>", "NDPK", "from", "different", "species", "by", "human", "casein", "kinase", "2", "CK-2", ")", "."], "h": {"id": "C0909712", "name": "C0909712#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["Novel", "proteins", "were", "identified", "from", "matches", "with", "H.", "contortus", "ESTs", "displaying", "high", "similarity", "with", "proteins", "like", "cyclophilins", ",", "C0909712#ent", "<e1>", "OV39", "antigen", "and", "undescribed", "C1334043#ent", "<e2>", "of", "Caenorhabditis", "elegans"], "h": {"id": "C0909712", "name": "C0909712#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [24, 25]}}
{"token": ["To", "compare", "the", "cyclooxygenase", "(", "COX", ")", "activity", "and", "anti-inflammatory", "effects", "the", "C0003211#ent", "<e1>", "NSAIDs", ")", "ketorolac", "tromethamine", "ketorolac", ")", "and", "bromfenac", "sodium", "C0107211#ent", "<e2>", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}, "relation": "structural_class_of", "t": {"id": "C0107211", "name": "C0107211#ent", "pos": [23, 24]}}
{"token": ["To", "compare", "the", "cyclooxygenase", "(", "COX", ")", "activity", "and", "anti-inflammatory", "effects", "the", "nonsteroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", "ketorolac", "tromethamine", "ketorolac", ")", "and", "bromfenac", "sodium", "C0107211#ent", "<e2>", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [15, 16]}, "relation": "structural_class_of", "t": {"id": "C0107211", "name": "C0107211#ent", "pos": [25, 26]}}
{"token": ["To", "compare", "the", "cyclooxygenase", "(", "COX", ")", "activity", "and", "anti-inflammatory", "effects", "the", "C0003211#ent", "<e1>", "NSAIDs", ")", "ketorolac", "tromethamine", "ketorolac", ")", "and", "C0107211#ent", "<e2>", "bromfenac", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}, "relation": "structural_class_of", "t": {"id": "C0107211", "name": "C0107211#ent", "pos": [21, 22]}}
{"token": ["These", "results", "may", "imply", "that", "the", "clamp", "not", "only", "acts", "to", "hold", "the", "C1335440#ent", "<e1>", "on", "the", "DNA", "but", "also", "prevents", "excessive", "C0272414#ent", "<e2>", "along", "the", "DNA", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0272414", "name": "C0272414#ent", "pos": [22, 23]}}
{"token": ["In", "both", "patients", ",", "C0040156#ent", "<e1>", "preceded", "the", "development", "of", "the", "C0009324#ent", "<e2>"], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", ",", "we", "describe", "an", "analysis", "focused", "at", "identifying", "C0086376#ent", "<e1>", "involved", "in", "the", "recovery", "of", "the", "archaeon", "Sulfolobus", "solfataricus", "strain", "C1425724#ent", "<e2>", "from", "Ni-induced", "stress", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1425724", "name": "C1425724#ent", "pos": [23, 24]}}
{"token": ["During", "treatment", ",", "seven", "girls", "had", "evidence", "of", "C0342543#ent", "<e1>", "hence", ",", "the", "GnRH", "agonist", "C0083220#ent", "<e2>", "(", "4", "microg/kg.d", "sc", ")", "was", "added", "to", "their", "regimen", "."], "h": {"id": "C0342543", "name": "C0342543#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0083220", "name": "C0083220#ent", "pos": [15, 16]}}
{"token": ["Twenty", "girls", "with", "C0342543#ent", "<e1>", "assigned", "randomly", "to", "receive", "C0083220#ent", "<e2>", "for", "9", "months", "at", "a", "dose", "of", "1", ",", "2", ",", "or", "4", "micrograms/", "kg.day", "."], "h": {"id": "C0342543", "name": "C0342543#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0083220", "name": "C0083220#ent", "pos": [9, 10]}}
{"token": ["Although", "we", "can", "not", "exclude", "the", "possibility", "that", "the", "C0003448#ent", "<e1>", "the", "resolution", "of", "the", "C0276253#ent", "<e2>", "it", "appears", "most", "probable", "that", "the", "C0276253#ent", "<e2>", "spontaneously", "."], "h": {"id": "C0003448", "name": "C0003448#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0276253", "name": "C0276253#ent", "pos": [15, 16]}}
{"token": ["Another", "patient", "diagnosed", "as", "miliary", "tuberculosis", "improved", "under", "treatment", "with", "C0003448#ent", "<e1>", "but", "died", "of", "C0276253#ent", "<e2>"], "h": {"id": "C0003448", "name": "C0003448#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0276253", "name": "C0276253#ent", "pos": [15, 16]}}
{"token": ["Sav1866", "is", "C1512488#ent", "<e1>", "with", "the", "clinically", "relevant", "human", "P-glycoprotein", "(", "C1704939#ent", "<e2>", ")", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [11, 12]}}
{"token": ["Leishmania", "also", "contains", "a", "P-glycoprotein", ",", "C1512488#ent", "<e1>", "to", "the", "mammalian", "C1704939#ent", "<e2>", ",", "that", "is", "involved", "in", "multidrug", "resistance"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "AdrR", "cells", "were", "found", "to", "contain", "amplified", "and", "overexpressed", "sequences", "which", "were", "C1512488#ent", "<e1>", "to", "hamster", "C1704939#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [19, 20]}}
{"token": ["These", "data", "demonstrate", "that", "APC", "is", "one", "of", "a", "small", "number", "of", "unique", "C2717971#ent", "<e1>", "do", "not", "interact", "with", "C2987172#ent", "<e2>"], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2987172", "name": "C2987172#ent", "pos": [19, 20]}}
{"token": ["The", "cutaneous", "manifestations", "of", "C0011633#ent", "<e1>", "are", "often", "resistant", "to", "C0003374#ent", "<e2>", "and", "immunosuppressive", "therapies"], "h": {"id": "C0011633", "name": "C0011633#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [10, 11]}}
{"token": ["One", "of", "the", "most", "potent", "toxins", "known", "is", "the", "C3536756#ent", "<e1>", "soman", ",", "which", "produces", "severe", "C4048158#ent", "<e2>", "and", "cell", "loss", "the", "central", "nervous", "system"], "h": {"id": "C3536756", "name": "C3536756#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [16, 17]}}
{"token": ["The", "biosynthesis", "of", "C3536949#ent", "<e1>", "requires", "the", "steroidogenic", "acute", "regulatory", "protein", "StAR", ")", "and", "the", "C1413855#ent", "<e2>", "3", "beta", "HSDII", ",", "P450c17", ",", "17", "beta", "HSDIII", ",", "and", "5", "alpha-reductase", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413855", "name": "C1413855#ent", "pos": [15, 16]}}
{"token": ["Neurological", "examination", "a", "C0007760#ent", "<e1>", "a", "posterior", "radiculo-cordonal", "syndrome", "and", "a", "dysmorphic", "syndrome", "characterise", "C0016719#ent", "<e2>"], "h": {"id": "C0007760", "name": "C0007760#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0016719", "name": "C0016719#ent", "pos": [14, 15]}}
{"token": ["The", "C1415885#ent", "<e1>", "EGR-1", ",", "encodes", "a", "C2826562#ent", "<e2>", "is", "involved", "in", "growth", "and", "differentiation", "of", "a", "variety", "of", "cell", "types"], "h": {"id": "C1415885", "name": "C1415885#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2826562", "name": "C2826562#ent", "pos": [7, 8]}}
{"token": ["An", "unresolved", "question", "of", "many", "C0022658#ent", "<e1>", "the", "progression", "of", "C0022661#ent", "<e2>", "end-stage", "renal", "insufficiency", "every", "year", "many", "patients", "must", "be", "submitted", "to", "extracorporeal", "haemodialysis", "a", "high", "cost", "for", "society", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [10, 11]}}
{"token": ["The", "C0022658#ent", "<e1>", "usually", "asymptomatic", "until", "C0022661#ent", "<e2>", "occur", "within", "the", "first", "decade", "after", "HSCT", ",", "and", "are", "mainly", "related", "with", "the", "use", "of", "nephrotoxic", "drugs", "as", "calcineurin", "inhibitors", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [6, 7]}}
{"token": ["Pharmacological", "inhibition", "of", "the", "renin-angiotensin-aldosteron", "system", "RAAS", ")", "constitutes", "a", "cornerstone", "strategy", "in", "the", "management", "of", "patients", "with", "C0022658#ent", "<e1>", "proteinuria", "and", "with", "C0022661#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [23, 24]}}
{"token": ["By", "elevating", "[Ca2+]i", ",", "ATP", "and", "the", "C3536929#ent", "<e1>", "carbachol", "both", "activated", "C1413043#ent", "<e2>", "+", "-sensitive", "membrane", "currents", ",", "which", "were", "measured", "by", "whole-cell", "and", "cell-attached", "patch-clamp", "recordings", "."], "h": {"id": "C3536929", "name": "C3536929#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["However", ",", "only", "the", "transformed", "cell", "line", "responsive", "to", "C3536929#ent", "<e1>", "carbamylcholine", "in", "terms", "of", "C1413043#ent", "<e2>", "+", "influx", "and", "polyphosphoinositide", "hydrolysis", "whereas", "the", "normal", "cell", "line", "unresponsive", "."], "h": {"id": "C3536929", "name": "C3536929#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [15, 16]}}
{"token": ["ATP", "and", "the", "C3536929#ent", "<e1>", "carbachol", "increased", "intracellular", "C1413043#ent", "<e2>", "+", "even", "in", "the", "absence", "of", "extracellular", "C1413043#ent", "<e2>", "+", "."], "h": {"id": "C3536929", "name": "C3536929#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [8, 9]}}
{"token": ["Although", "expression", "of", "the", "mitogen-activated", "protein", "kinase-specific", "phosphatase", "MKP-1", ")", "completely", "inhibited", "the", "insulin", "stimulation", "C0752312#ent", "<e1>", "activity", "both", "in", "vitro", "in", "vivo", "C4225412#ent", "<e2>", "phosphorylation", "and", "the", "dissociation", "of", "the", "Grb2-SOS", "complex", "unaffected", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4225412", "name": "C4225412#ent", "pos": [23, 24]}}
{"token": ["Although", "EGF", "stimulation", "of", "the", "mutant", "EGF", "receptor", "C0752312#ent", "<e1>", "and", "phosphorylation", "of", "both", "Shc", "and", "C4225412#ent", "<e2>", ",", "it", "fails", "to", "directly", "associate", "with", "either", "Shc", "or", "Grb2", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4225412", "name": "C4225412#ent", "pos": [16, 17]}}
{"token": ["Second", "generation", "C0003290#ent", "<e1>", "preferred", "for", "the", "elderly", "and", "those", "with", "C0018799#ent", "<e2>", "they", "tend", "to", "have", "milder", "side", "effects", "are", "less", "toxic", "in", "overdose", "."], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [11, 12]}}
{"token": ["Changes", "in", "cutaneous", "innervation", "have", "been", "found", "in", "various", "C3875321#ent", "<e1>", "in", "xerotic", "skin", "in", "C0206245#ent", "<e2>"], "h": {"id": "C3875321", "name": "C3875321#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0206245", "name": "C0206245#ent", "pos": [15, 16]}}
{"token": ["C0033384#ent", "<e1>", "a", "known", "target", "of", "C0020223#ent", "<e2>", "."], "h": {"id": "C0033384", "name": "C0033384#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [6, 7]}}
{"token": ["also", "produced", "decreases", "in", "C0158996#ent", "<e1>", "and", "RBF", "and", "increases", "in", "AoF", ",", "VBF", "and", "C1428360#ent", "<e2>", "."], "h": {"id": "C0158996", "name": "C0158996#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "evidence", "was", "obtained", "that", "the", "C1254351#ent", "<e1>", "may", "hinder", "intracellular", "transport", "of", "a", "135", "kd", "C1305923#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [17, 18]}}
{"token": ["This", "study", "was", "designed", "to", "examine", "the", "effects", "of", "C1414386#ent", "<e1>", "combined", "with", "the", "coronally", "positioned", "C1412362#ent", "<e2>", "over", "an", "18-month", "postoperative", "period", "."], "h": {"id": "C1414386", "name": "C1414386#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412362", "name": "C1412362#ent", "pos": [16, 17]}}
{"token": ["These", "effects", "of", "C0017356#ent", "<e1>", "depend", "on", "the", "small", "C0018296#ent", "<e2>", "Cdc42", "and", "guanine", "nucleotide", "exchange", "factor", "."], "h": {"id": "C0017356", "name": "C0017356#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [9, 10]}}
{"token": ["Results", "suggest", "that", "C0772125#ent", "<e1>", "may", "be", "of", "clinical", "value", "an", "anti-inflammatory", "and", "C0728960#ent", "<e2>", "or", "in", "conjunction", "with", "NSAIDs", "."], "h": {"id": "C0772125", "name": "C0772125#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [13, 14]}}
{"token": ["C0751984#ent", "<e1>", "to", "a", "superfamily", "of", "C0018296#ent", "<e2>", "related", "to", "the", "protooncogene", "ras", "and", "function", "as", "master", "control", "elements", "for", "a", "range", "of", "cellular", "functions"], "h": {"id": "C0751984", "name": "C0751984#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [6, 7]}}
{"token": ["All", "of", "these", "C0003174#ent", "<e1>", ",", "differently", "from", "versicolorin", "A", "not", "show", "clear", "response", "of", "C1333237#ent", "<e2>"], "h": {"id": "C0003174", "name": "C0003174#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [15, 16]}}
{"token": ["Of", "the", "C0003174#ent", "<e1>", "tested", ",", "1-hydroxyanthraquinone", "and", "1,8-dihydroxyanthraquinone", "(", "chrysazin", ")", "induced", "C1333237#ent", "<e2>", "synthesis", "in", "rat", "hepatocytes", ",", "indicating", "their", "genotoxic", "activity"], "h": {"id": "C0003174", "name": "C0003174#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", ",", "except", "to", "rule", "out", "C0030785#ent", "<e1>", "the", "presence", "of", "C0242172#ent", "<e2>", "CT", "is", "usually", "the", "only", "special", "radiologic", "test", "should", "be", "performed", "to", "localize", "a", "suspected", "intra-abdominal", "abscess"], "h": {"id": "C0030785", "name": "C0030785#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242172", "name": "C0242172#ent", "pos": [14, 15]}}
{"token": ["Deoxyadenosine", "has", "been", "implicated", "in", "the", "lymphocytopenia", "that", "occurs", "in", "immunodeficient", "children", "with", "an", "inherited", "deficiency", "of", "C1412179#ent", "<e1>", "C0001457#ent", "<e2>", ")", "and", "in", "leukemic", "patients", "treated", "with", "C0001457#ent", "<e2>", "inhibitor", "deoxycoformycin", "."], "h": {"id": "C1412179", "name": "C1412179#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [19, 20]}}
{"token": ["Drugs", "that", "were", "administered", "daily", "by", "gavage", "included", "isoniazid", "(", "INH", ")", ",", "C0014964#ent", "<e1>", "(", "EMB", ")", ",", "rifampin", "(", "C3890420#ent", "<e2>", ")", ",", "and", "moxifloxacin", "(", "MXF", ")", "."], "h": {"id": "C0014964", "name": "C0014964#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3890420", "name": "C3890420#ent", "pos": [21, 22]}}
{"token": ["Human", "VRK1", "(", "vaccinia-related", "kinase", "1", "is", "a", "novel", "C0072402#ent", "<e1>", "regulates", "several", "transcription", "factors", "including", "p53", ",", "C1708119#ent", "<e2>", "and", "c-Jun", ";", "and", "its", "loss", "results", "in", "defects", "of", "cell", "proliferation"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1708119", "name": "C1708119#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", "the", "role", "of", "5-HT(1B", ")", "and", "5-HT(1D)", "receptors", "targets", "for", "the", "antimigraine", "drugs", "known", "collectively", "as", "C1567966#ent", "<e1>", ",", "was", "examined", "in", "the", "C1417869#ent", "<e2>", "."], "h": {"id": "C1567966", "name": "C1567966#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [26, 27]}}
{"token": ["1", "The", "influence", "of", "the", "nonsteroidal", "anti-inflammatory", "drug", "naproxen", "glucose", "metabolism", "on", "C0040374#ent", "<e1>", "pharmacokinetics", "and", "pharmacodynamics", "has", "been", "studied", "in", "ten", "C0011860#ent", "<e2>"], "h": {"id": "C0040374", "name": "C0040374#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", "to", "C0023899#ent", "<e1>", "and", "kidney", "AACs", ",", "brain", "C3890007#ent", "<e2>", "displayed", "similar", "antigenic", "properties", "heart", "C3890007#ent", "<e2>", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3890007", "name": "C3890007#ent", "pos": [10, 11]}}
{"token": ["These", "results", "indicate", "that", "the", "induced", "rat", "C0023899#ent", "<e1>", "C3890007#ent", "<e2>", "is", "homologous", "to", "the", "constitutive", "rat", "brain", "C3890007#ent", "<e2>", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3890007", "name": "C3890007#ent", "pos": [9, 10]}}
{"token": ["Examination", "of", "ultra-thin", "sections", "of", "C0023899#ent", "<e1>", "in", "the", "electron", "microscope", "that", "C3890007#ent", "<e2>", ",", "administered", "alone", "or", "with", "DEX", ",", "resulted", "in", "a", "failure", "of", "hepatic", "glycogen", "accumulation", "to", "occur", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3890007", "name": "C3890007#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "we", "assessed", "the", "effect", "of", "mutants", "on", "wt", "C1415171#ent", "<e1>", "with", "receptor", "modifications", ",", "by", "themselves", ",", "diminished", "C4283796#ent", "<e2>", "."], "h": {"id": "C1415171", "name": "C1415171#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [21, 22]}}
{"token": ["Dominant", "negative", "effects", "of", "mutant", "gonadotropin-releasing", "hormone", "GnRH", ")", "receptors", "(", "C1415171#ent", "<e1>", ";", "isolated", "from", "patients", "with", "idiopathic", "hypogonadotropic", "hypogonadism", "on", "plasma", "membrane", "expression", "C4283796#ent", "<e2>", ")", "and", "function", "of", "the", "wt", "C1415171#ent", "<e1>", "were", "examined", "."], "h": {"id": "C1415171", "name": "C1415171#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [25, 26]}}
{"token": ["Griseolic", "acid", "derivatives", "having", "a", "different", "substituent", "at", "the", "N1,C6,C2", "'", "or", "C7'", "position", "the", "C1512076#ent", "<e1>", "synthesized", "and", "their", "structure", "activity", "relationship", "to", "C0056696#ent", "<e2>", "inhibitory", "activity", "investigated", "."], "h": {"id": "C1512076", "name": "C1512076#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0056696", "name": "C0056696#ent", "pos": [24, 25]}}
{"token": ["Sequential", "treatment", "infusional", "5-FU/FA", "plus", "C0069717#ent", "<e1>", "followed", "by", "5-FU/FA", "plus", "C0594375#ent", "<e2>", "or", "vice", "versa", "results", "in", "a", "median", "survival", "20", "months", "."], "h": {"id": "C0069717", "name": "C0069717#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "we", "evaluated", "the", "anti-proliferative", "potential", "of", "MTA", "combined", "with", "drugs", "known", "to", "exert", "therapeutic", "activity", "colon", "cancer", "including", "5-fluorouracil", ",", "C0069717#ent", "<e1>", ",", "and", "SN38", ",", "the", "active", "metabolite", "C0594375#ent", "<e2>", "."], "h": {"id": "C0069717", "name": "C0069717#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [31, 32]}}
{"token": ["We", "observe", "higher", "similarity", "in", "the", "conformations", "of", "ATP", "bound", "to", "active", "forms", "C0033640#ent", "<e1>", "to", "ATP", "conformations", "in", "the", "inactive", "forms", "of", "C0031727#ent", "<e2>", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [23, 24]}}
{"token": ["C0033640#ent", "<e1>", "a", "pivotal", "role", "in", "cell", "signaling", "and", "dysregulation", "of", "many", "C0031727#ent", "<e2>", "has", "been", "linked", "to", "disease", "development"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}}
{"token": ["However", ",", "apoptosis", "has", "recently", "been", "demonstrated", "in", "animal", "models", "C0018801#ent", "<e1>", "well", "as", "in", "explanted", "hearts", "from", "patients", "with", "C0022661#ent", "<e2>", "cardiac", "transplantation"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [20, 21]}}
{"token": ["We", "have", "characterized", "the", "expression", "of", "multiple", "apoptotic", "proteins", "a", "panel", "of", "BL", "cell", "lines", "describe", "cell", "lines", "loss", "of", "cIAP1", ",", "C1332415#ent", "<e1>", ",", "Bax", ",", "Bak", ",", "Bcl-Xs", "and", "C0257535#ent", "<e2>"], "h": {"id": "C1332415", "name": "C1332415#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [31, 32]}}
{"token": ["Platelet", "heparanase", "inhibited", "by", "heparin", "analogues", "which", "also", "inhibited", "tumour", "heparanase", "suggesting", "that", "C0032594#ent", "<e1>", "inhibit", "tumour", "metastasis", "act", "to", "prevent", "both", "tumour", "cell", "C1367469#ent", "<e2>", "degradation", "of", "endothelial", "cell", "surface", "HS", "and", "the", "basal", "laminar"], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [24, 25]}}
{"token": ["EPS-degradation", "was", "determined", "from", "the", "decrease", "in", "C0032594#ent", "<e1>", "concentration", "and", "by", "high-performance", "size", "exclusion", "chromatography", "C1367469#ent", "<e2>", ")", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [16, 17]}}
{"token": ["C0032594#ent", "<e1>", "their", "anti-inflammatory", "effect", "inhibiting", "the", "endoglycosidase", ",", "C1367469#ent", "<e2>", ",", "which", "plays", "a", "key", "role", "in", "the", "solubilization", "of", "BM", "by", "invading", "leucocytes", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [9, 10]}}
{"token": ["C1413627#ent", "<e1>", "but", "not", "DEX", "replacement", "was", "able", "to", "reinstate", "C1538430#ent", "<e2>", "in", "ADX", "rats", "."], "h": {"id": "C1413627", "name": "C1413627#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538430", "name": "C1538430#ent", "pos": [10, 11]}}
{"token": ["When", "GFP-lamin", "C", "was", "expressed", "in", "SW13", "cells", "neither", "the", "endogenous", "nor", "the", "exogenous", "C1416877#ent", "<e1>", "localised", "to", "the", "NE", "and", "C0295734#ent", "<e2>", "remained", "in", "the", "ER", "."], "h": {"id": "C1416877", "name": "C1416877#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0295734", "name": "C0295734#ent", "pos": [21, 22]}}
{"token": ["In", "two", "cell", "lines", "did", "not", "express", "lamin", "A", "did", "express", "C1416877#ent", "<e1>", "C1416877#ent", "<e1>", "well", "as", "C0295734#ent", "<e1>", "was", "mis-localised", "."], "h": {"id": "C1416877", "name": "C1416877#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0295734", "name": "C0295734#ent", "pos": [17, 18]}}
{"token": ["Unlike", "a", "simple", "fungus", "ball", "the", "saprophytic", "form", "of", "C0004030#ent", "<e1>", ")", ",", "the", "rounded", "density", "invasive", "pulmonary", "aspergillosis", "of", "sequestrum", "of", "C0011407#ent", "<e2>", "lung", "tissue", "to", "blood", "vessel", "invasion", "by", "Aspergillus", "hyphae"], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011407", "name": "C0011407#ent", "pos": [22, 23]}}
{"token": ["This", "uncommon", "association", "might", "represent", "a", "possible", "overlap", "syndrome", "between", "these", "C2717865#ent", "<e1>", "IgA", "nephropathy", "simply", "a", "new", "type", "of", "C0156221#ent", "<e2>", "that", "must", "be", "taken", "into", "account", "in", "these", "vasculitides", "."], "h": {"id": "C2717865", "name": "C2717865#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [20, 21]}}
{"token": ["The", "patient", "presented", "with", "diffuse", "alveolar", "haemorrhage", ",", "C2717865#ent", "<e1>", "rapid", "progressive", "C0156221#ent", "<e2>", "and", "leukocytoclastic", "vasculitis", "the", "skin", "."], "h": {"id": "C2717865", "name": "C2717865#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [12, 13]}}
{"token": ["Hydralazine", "can", "also", "cause", "a", "systemic", "vasculitis", "a", "C2717865#ent", "<e1>", "rapidly", "progressive", "C0156221#ent", "<e2>", ",", "which", "is", "associated", "with", "autoantibodies", "directed", "against", "components", "of", "the", "neutrophil", "cytoplasm"], "h": {"id": "C2717865", "name": "C2717865#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [12, 13]}}
{"token": ["This", "study", "demonstrates", "that", "the", "effect", "of", "C0005330#ent", "<e1>", "on", "serum", "C3812647#ent", "<e2>", "activity", "is", "confined", "to", "the", "liver", "and", "biliary", "isoenzymes.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0005330", "name": "C0005330#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3812647", "name": "C3812647#ent", "pos": [11, 12]}}
{"token": ["Thirty-eight", "days", "after", "the", "first", "administration", "of", "this", "organo-arsenic", "compound", "C0032238#ent", "<e1>", ",", "distal", "paresthesias", "rapidly", "progressive", "weakness", "developed", "in", "all", "four", "C0030196#ent", "<e2>", "."], "h": {"id": "C0032238", "name": "C0032238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [22, 23]}}
{"token": ["C0050393#ent", "<e1>", "significantly", "reduced", "integrated", "glycemia", ",", "which", "correlated", "with", "C1412332#ent", "<e2>", "excretion", "rates", ",", "and", "exerts", "a", "salutary", "effect", "diabetic", "renal", "dysfunction"], "h": {"id": "C0050393", "name": "C0050393#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [10, 11]}}
{"token": ["Gastrin", "and", "pituitary", "adenylate", "cyclase-activating", "peptide", "C1412228#ent", "<e1>", ")", "stimulate", "histamine", "secretion", "from", "isolated", "C1332684#ent", "<e2>", "while", "somatostatin", "and", "galanin", "inhibit", "stimulated", "secretion", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332684", "name": "C1332684#ent", "pos": [14, 15]}}
{"token": ["Three", "patients", "with", "C0032453#ent", "<e1>", "treated", "successfully", "with", "C0010980#ent", "<e2>", "."], "h": {"id": "C0032453", "name": "C0032453#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [8, 9]}}
{"token": ["We", "present", "the", "case", "of", "a", "4-year-old", "boy", "with", "C0024530#ent", "<e1>", "who", "developed", "C0035220#ent", "<e2>", "severe", "hypoxemia", "refractory", "to", "mechanical", "ventilation", "inhaled", "nitric", "oxide"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [13, 14]}}
{"token": ["The", "effects", "of", "ipsapirone", "and", "cannabidiol", "(", "CBD", ")", "on", "healthy", "volunteers", "to", "a", "simulated", "public", "speaking", "C1426332#ent", "<e1>", ")", "test", "were", "compared", "with", "those", "of", "the", "C4048284#ent", "<e2>", "diazepam", "and", "placebo", "."], "h": {"id": "C1426332", "name": "C1426332#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [27, 28]}}
{"token": ["Homozygous", "members", "the", "mutant", "Gunn", "strain", "of", "Wistar", "rats", "an", "inherited", "autosomal", "recessive", "deficiency", "C0041560#ent", "<e1>", "in", "unconjugated", "C0020433#ent", "<e2>", "and", "jaundice", "."], "h": {"id": "C0041560", "name": "C0041560#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020433", "name": "C0020433#ent", "pos": [18, 19]}}
{"token": ["C0720099#ent", "<e1>", "were", "blocked", "by", "methylxanthine", "C2936569#ent", "<e2>"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936569", "name": "C2936569#ent", "pos": [6, 7]}}
{"token": ["Sera", "from", "women", "in", "the", "AI", "and", "C3538698#ent", "<e1>", "groups", "both", "recognized", "C1415790#ent", "<e2>", "more", "frequently", "and", "at", "a", "higher", "overall", "level", "than", "sera", "from", "healthy", "uninfected", "controls", "."], "h": {"id": "C3538698", "name": "C3538698#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415790", "name": "C1415790#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "neutrophil", "attractant/activation", "protein", "C1366571#ent", "<e1>", ")", "(", "also", "known", "as", "interleukin", "8", "C1705592#ent", "<e2>", ")", ")", "attracts", "and", "activates", "human", "neutrophils", "but", "it", "is", "not", "a", "chemoattractant", "for", "human", "monocytes", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [15, 16]}}
{"token": ["IL-8", "(", "or", "C1366571#ent", "<e1>", ")", "activates", "the", "receptors", "CXCR1", "IL-8RA", ")", "and", "CXCR2", "(", "C1705592#ent", "<e2>", ")", "to", "induce", "chemotaxis", "in", "leukocytes", ",", "but", "only", "CXCR1", "mediates", "cytotoxic", "and", "cross-regulatory", "signals", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [15, 16]}}
{"token": ["The", "origin", "of", "C0917964#ent", "<e1>", "in", "patients", "with", "C1538716#ent", "<e2>", "was", "not", "revealed", "by", "this", "study", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1538716", "name": "C1538716#ent", "pos": [8, 9]}}
{"token": ["However", ",", "C0077845#ent", "<e1>", "specifically", "processes", "U", ":", "G", "lesions", "to", "immunoglobulin", "variable", "V", ")", "C1417679#ent", "<e2>", "during", "somatic", "hypermutation", "and", "class-switch", "recombination"], "h": {"id": "C0077845", "name": "C0077845#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["Aromatase", "deficiency", "results", "from", "C3899988#ent", "<e1>", "inheritance", "of", "mutations", "in", "the", "C1366496#ent", "<e2>"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366496", "name": "C1366496#ent", "pos": [11, 12]}}
{"token": ["The", "European", "Atrial", "Fibrillation", "Trial", "only", "C4049859#ent", "<e1>", "patients", "with", "prior", "stroke", "and", "C0917805#ent", "<e2>", "and", "confirmed", "the", "superiority", "of", "warfarin", "over", "ASA", "for", "secondary", "prevention"], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0917805", "name": "C0917805#ent", "pos": [13, 14]}}
{"token": ["Laboratory", "studies", "shown", "that", "this", "C1254351#ent", "<e1>", "inhibits", "bone", "resorption", "in", "vitro", "that", "short-term", "treatment", "in", "vivo", "increases", "the", "C2936886#ent", "<e2>", "content", "of", "bone", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [19, 20]}}
{"token": ["It", "is", "supposed", "that", "the", "C1254351#ent", "<e1>", "improves", "the", "intestinal", "resorption", "C2936886#ent", "<e2>", "and", "phosphorus", "and", "suppresses", "the", "bone", "resorption"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [11, 12]}}
{"token": ["Activity", "of", "the", "C1254351#ent", "<e1>", "was", "found", "to", "be", "strongly", "correlated", "with", "the", "C2936886#ent", "<e2>", "concentration", "in", "test", "media"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [13, 14]}}
{"token": ["A", "neuron-specific", "promoter", "CaMKIIalpha", "(", "C1413099#ent", "<e1>", "driven", "tTA", "(", "tetracycline", "transactivator", "mice", "were", "crossed", "with", "C1421114#ent", "<e2>", "(", "tetracycline", "responsive", "element", ")", "driven", "mitochondrial", "targeted", "enhanced", "yellow", "fluorescent", "protein", "eYFP", ")", "mice", "."], "h": {"id": "C1413099", "name": "C1413099#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [16, 17]}}
{"token": ["All", "tissues", "contained", "sst1", ",", "sst2", ",", "and", "C2982407#ent", "<e1>", "transcripts", ",", "but", "not", "C0210233#ent", "<e2>", ",", "while", "small", "amounts", "of", "sst5", "mRNA", "were", "only", "found", "in", "normal", "pineal", "glands"], "h": {"id": "C2982407", "name": "C2982407#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0210233", "name": "C0210233#ent", "pos": [14, 15]}}
{"token": ["All", "12", "normal", "testicular", "tissues", "contained", "C2982407#ent", "<e1>", "and", "sst5", "receptor", "transcripts", "whereas", "C0210233#ent", "<e2>", "was", "present", "in", "almost", "all", "(", "11", "of", "12", ")", "."], "h": {"id": "C2982407", "name": "C2982407#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0210233", "name": "C0210233#ent", "pos": [13, 14]}}
{"token": ["Control", "cells", "expressed", "predominantly", "sst2", "and", "C2982407#ent", "<e1>", "transcripts", ";", "sst1", "mRNA", "was", "present", "in", "moderate", "amounts", "whereas", "C0210233#ent", "<e2>", "and", "sst5", "were", "only", "weakly", "expressed", "."], "h": {"id": "C2982407", "name": "C2982407#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0210233", "name": "C0210233#ent", "pos": [18, 19]}}
{"token": ["Taken", "together", ",", "our", "results", "indicate", "that", "C1538643#ent", "<e1>", "negatively", "regulates", "E1AF-mediated", "transcription", "by", "both", "C1333362#ent", "<e2>", "sumoylation", "in", "a", "dependent", "and", "independent", "fashion", "."], "h": {"id": "C1538643", "name": "C1538643#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333362", "name": "C1333362#ent", "pos": [15, 16]}}
{"token": ["We", "further", "demonstrated", "that", "C1538643#ent", "<e1>", "enhanced", "sumoylation", "of", "C1333362#ent", "<e2>", "as", "a", "specific", "SUMO-E3", "ligase", "."], "h": {"id": "C1538643", "name": "C1538643#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333362", "name": "C1333362#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "extrahepatic", "peribiliary", "glands", "produce", "alpha-amylase", "isozymes", "trypsin", "and", "C0443469#ent", "<e1>", "secrete", "these", "C3540790#ent", "<e2>", "into", "lumens", "of", "the", "extrahepatic", "bile", "duct"], "h": {"id": "C0443469", "name": "C0443469#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}}
{"token": ["At", "birth", "both", "C0443469#ent", "<e1>", "carboxylic", "ester", "hydrolase", "two", "important", "lipolytic", "C3540790#ent", "<e2>", "secreted", "by", "the", "pancreas", ",", "are", "present", "in", "duodenal", "contents", "but", "the", "activities", "of", "these", "C3540790#ent", "<e2>", "are", "low", "."], "h": {"id": "C0443469", "name": "C0443469#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["The", "generation", "of", "proinflammatory", "eicosanoids", "in", "response", "to", "tumor", "necrosis", "factor", "TNF", ")", "involves", "the", "activation", "of", "C1333201#ent", "<e1>", "cPLA(2", ")", ")", ",", "presumably", "by", "phosphorylation", "through", "C0600388#ent", "<e2>", "ERK", ")", "."], "h": {"id": "C1333201", "name": "C1333201#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [27, 28]}}
{"token": ["The", "source", "of", "the", "isolates", "was", ";", "three", "patients", "with", "recurrent", "dendritic", "keratitis", "three", "with", "C1561643#ent", "<e1>", "three", "with", "C0022573#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022573", "name": "C0022573#ent", "pos": [19, 20]}}
{"token": ["In", "patients", "with", "C0011881#ent", "<e1>", "addition", "of", "aliskiren", "to", "C0126174#ent", "<e2>", ",", "100", "mg", "resulted", "in", "a", "20", "%", "greater", "reduction", "in", "proteinuria", "."], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [9, 10]}}
{"token": ["Adverse", "effects", "hGH", "treatment", "(", "pseudotumor", "cerebri", "C0155300#ent", "<e1>", ",", "retinal", "changes", "mimicking", "C0011884#ent", "<e2>", "neovascularization", ")", "have", "been", "reported", "in", "some", "papers", "."], "h": {"id": "C0155300", "name": "C0155300#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [13, 14]}}
{"token": ["Using", "mutants", "of", "all", "individual", "C2717970#ent", "<e1>", "in", "RPTPalpha", "and", "constructs", "encoding", "the", "individual", "C0085536#ent", "<e2>", "we", "located", "the", "intermolecular", "disulfide", "bond", "the", "catalytic", "Cys-723", "in", "D2", "."], "h": {"id": "C2717970", "name": "C2717970#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [14, 15]}}
{"token": ["Surgical", "denervation", "the", "adult", "SCG", "increased", "C0085648#ent", "<e1>", "levels", "of", "C1335871#ent", "<e2>", "(", "SS", ")", "mRNA", "more", "than", "11-fold", ",", "and", "levels", "of", "the", "mRNA", "remained", "elevated", "14", "days", "after", "surgery", "."], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335871", "name": "C1335871#ent", "pos": [10, 11]}}
{"token": ["Treatment", "of", "sympathetic", "neurons", "culture", "medium", "conditioned", "by", "exposure", "to", "C0085648#ent", "<e1>", "nonneuronal", "cells", "similarly", "elevated", "C1335871#ent", "<e2>", "mRNA", "."], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335871", "name": "C1335871#ent", "pos": [16, 17]}}
{"token": ["Coculture", "of", "sympathetic", "neurons", "C0085648#ent", "<e1>", "nonneuronal", "cells", "elevated", "levels", "of", "C1335871#ent", "<e2>", "mRNA", "but", "did", "not", "alter", "neuronal", "synthesis", "content", ",", "or", "release", "of", "somatostatin", "."], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335871", "name": "C1335871#ent", "pos": [11, 12]}}
{"token": ["To", "assess", "patient", "satisfaction", "intravitreous", "C0032144#ent", "<e1>", "injections", "for", "subretinal", "hemorrhages", "secondary", "to", "age-related", "macular", "degeneration", "C0017921#ent", "<e2>", ")", "and", "to", "analyse", "how", "it", "relates", "to", "the", "patients", "'", "postoperative", "visual", "and", "functional", "abilities", "."], "h": {"id": "C0032144", "name": "C0032144#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017921", "name": "C0017921#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "the", "presence", "and", "potential", "involvement", "of", "members", "of", "the", "C0032144#ent", "<e1>", "Plg/PA", ")", "system", "in", "the", "exudative", "form", "of", "age-related", "macular", "degeneration", "C0017921#ent", "<e2>", ")", "."], "h": {"id": "C0032144", "name": "C0032144#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017921", "name": "C0017921#ent", "pos": [24, 25]}}
{"token": ["Radiological", "findings", "of", "vasculitis", "in", "the", "angiitis-granulomatosis", "group", "nodular", "and", "patchy", "opacities", ",", "whereas", "the", "principal", "feature", "of", "those", "C0029896#ent", "<e1>", "causing", "widespread", "capillaritis", "is", "C0521530#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0521530", "name": "C0521530#ent", "pos": [25, 26]}}
{"token": ["Also", ",", "measurement", "of", "urinary", "6", "ratio", "provides", "a", "simple", "non-invasive", "method", "to", "monitor", "C1142644#ent", "<e1>", "enzyme", "induction", "during", "administration", "of", "C0006949#ent", "<e2>", "antiepileptic", "drug"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [14, 15]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0006949", "name": "C0006949#ent", "pos": [21, 22]}}
{"token": ["C0878677#ent", "<e1>", "an", "X-linked", "cardioskeletal", "myopathy", "by", "primary", "deficiency", "lysosome-associated", "membrane", "protein-2", "C3890213#ent", "<e2>", ")", ",", "is", "clinically", "characterized", "by", "cardiomyopathy", ",", "myopathy", ",", "and", "variable", "mental", "retardation"], "h": {"id": "C0878677", "name": "C0878677#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890213", "name": "C3890213#ent", "pos": [12, 13]}}
{"token": ["C0878677#ent", "<e1>", "an", "X-linked", "hypertrophic", "cardiomyopathy", "is", "caused", "by", "primary", "deficiency", "lysosome-associated", "membrane", "protein", "C3890213#ent", "<e2>", ")", "."], "h": {"id": "C0878677", "name": "C0878677#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890213", "name": "C3890213#ent", "pos": [14, 15]}}
{"token": ["Expression", "and", "C0812382#ent", "<e1>", "PPARalpha", ",", "PPARbeta/delta", ",", "and", "C1706243#ent", "<e2>", "rapidly", "decreased", "after", "cell", "isolation", "remained", "persistently", "reduced", "during", "the", "14-day", "culture", "period", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706243", "name": "C1706243#ent", "pos": [9, 10]}}
{"token": ["Radioligand", "binding", "studies", "provide", "direct", "evidence", "that", "both", "ambenonium", "and", "C0360174#ent", "<e1>", "are", "relatively", "potent", "C0242947#ent", "<e2>", "whereas", "physostigmine", "and", "other", "ChEI", "have", "little", "direct", "receptor", "activity", "."], "h": {"id": "C0360174", "name": "C0360174#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242947", "name": "C0242947#ent", "pos": [15, 16]}}
{"token": ["We", "show", "that", "C0206178#ent", "<e1>", "occur", "in", "patients", "with", "C0009326#ent", "<e2>", "receive", "immunosuppressive", "therapy"], "h": {"id": "C0206178", "name": "C0206178#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [9, 10]}}
{"token": ["Aim", "of", "the", "study", "was", "to", "evaluate", "efficacy", "and", "safety", "of", "long-term", "treatment", "of", "pravastatin", "+", "fenofibrate", "or", "C0074554#ent", "<e1>", "+", "ciprofibrate", "therapy", "the", "high-risk", "group", "patients", "with", "severe", "C0020476#ent", "<e2>"], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [29, 30]}}
{"token": ["C0907888#ent", "<e1>", "PrTX-III", ")", "is", "a", "phospholipase", "A2", "C0031667#ent", "<e2>", ",", "E.C.", "3.1.1.4", "phosphatide", "sn-2", "acylhydrolase", "isolated", "from", "Bothrops", "pirajai"], "h": {"id": "C0907888", "name": "C0907888#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [8, 9]}}
{"token": ["It", "seems", "that", "to", "achieve", "histologic", "typing", "lung", "cancer", "accurate", "as", "possible", ",", "C3811254#ent", "<e1>", "in", "combination", "with", "C2984561#ent", "<e2>", "and", "CK", "5/6", "might", "be", "useful", "components", "of", "immunohistochemical", "analysis", "poorly", "differentiated", "lung", "carcinomas", "biopsy", "tissues"], "h": {"id": "C3811254", "name": "C3811254#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2984561", "name": "C2984561#ent", "pos": [18, 19]}}
{"token": ["We", "have", "also", "investigated", "the", "effects", "of", "time", ",", "temperature", ",", "C1161352#ent", "<e1>", "antagonism", ",", "Ca++", "and", "C1704888#ent", "<e2>", "activators", "on", "the", "three", "measured", "responses", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704888", "name": "C1704888#ent", "pos": [17, 18]}}
{"token": ["Flesinoxan", "and", "C0050079#ent", "<e1>", "decreased", "tissue", "perfusion", "the", "heart", ",", "lungs", ",", "gastrointestinal", "tract", "C0235267#ent", "<e2>", ",", "and", "skin", ",", "but", "both", "renal", "and", "cerebral", "blood", "flows", "preserved", "as", "a", "result", "of", "increased", "vascular", "conductances", "."], "h": {"id": "C0050079", "name": "C0050079#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [14, 15]}}
{"token": ["Combination", "of", "chronic", "atrophic", "gastritis", "mostly", "related", "to", "C0850666#ent", "<e1>", "with", "hypergastrinaemia", "frequently", "causes", "linear", "and", "C0342496#ent", "<e2>", "argyrophil", "cells", ",", "whereas", "carcinoids", "are", "exceptional", "."], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0342496", "name": "C0342496#ent", "pos": [16, 17]}}
{"token": ["C1336737#ent", "<e1>", "TPMT", ")", "is", "an", "C0027203#ent", "<e2>", "that", "catalyzed", "the", "S-methylation", "of", "thiopurine", "drugs", "."], "h": {"id": "C1336737", "name": "C1336737#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}}
{"token": ["The", "activity", "of", "C1336737#ent", "<e1>", "TPMT", ")", ",", "a", "key", "C0027203#ent", "<e2>", "in", "the", "metabolism", "of", "purine", "analogues", "displays", "wide", "inter-subject", "variability", "partly", "due", "to", "a", "genetic", "polymorphism"], "h": {"id": "C1336737", "name": "C1336737#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["Adv-encoding", "kinase-deficient", "(", "C0026691#ent", "<e1>", ")", "and", "Y(402)F", "phosphorylation-deficient", "mutants", "of", "C1335273#ent", "<e2>", "also", "significantly", "reduced", "SERCA2", "mRNA", "(", "WT", ">", "C0026691#ent", "<e1>", ">", "Y(402)F", ")", "."], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [3, 4]}}
{"token": ["The", "efficacy", "of", "putative", "C1519837#ent", "<e1>", "i.e.", "LIGA", "20", ",", "nicotinamide", "and", "pramipexole", "(", "C1418850#ent", "<e2>", ")", "]", "varied", "depending", "upon", "the", "MPTP", "administration", "protocol"], "h": {"id": "C1519837", "name": "C1519837#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418850", "name": "C1418850#ent", "pos": [14, 15]}}
{"token": ["The", "major", "conditions", "for", "which", "the", "children", "were", "admitted", "were", "C0035243#ent", "<e1>", "surgical", "conditions", ",", "sepsis", ",", "tetanus", ",", "the", "C0018378#ent", "<e2>", "acute", "renal", "failure"], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [20, 21]}}
{"token": ["The", "present", "study", "describes", "a", "female", "patient", "who", "rapidly", "developed", "a", "severe", "C0037275#ent", "<e1>", "taking", "clarithromycin", "for", "C0001361#ent", "<e2>", "."], "h": {"id": "C0037275", "name": "C0037275#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001361", "name": "C0001361#ent", "pos": [17, 18]}}
{"token": ["All", "of", "the", "clinical", "S.", "maltophilia", "C1875400#ent", "<e1>", "tested", "produced", "the", "17", "kDa", "C1418657#ent", "<e2>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418657", "name": "C1418657#ent", "pos": [13, 14]}}
{"token": ["Actin-interacting", "protein", "1", "C3812153#ent", "<e1>", ")", "has", "emerged", "as", "a", "conserved", "C3539812#ent", "<e2>", "specifically", "enhances", "ADF/cofilin-induced", "actin", "dynamics", "."], "h": {"id": "C3812153", "name": "C3812153#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539812", "name": "C3539812#ent", "pos": [11, 12]}}
{"token": ["Our", "observations", "indicate", "that", "Rac1", "and", "C1366537#ent", "<e1>", "have", "distinct", "functions", "in", "C1332447#ent", "<e2>", "by", "Roundabout", "receptors", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [12, 13]}}
{"token": ["Comparable", "lineage", "differences", "in", "normal", "lymphoid", "versus", "nonlymphoid", "cells", "suggest", "a", "lineage-specific", "control", "of", "C1414689#ent", "<e1>", "expression", ",", "C1414689#ent", "<e1>", "activity", "increased", "in", "C0812385#ent", "<e1>", "blasts", "after", "in", "vivo", "exposure", "to", "MTX", "."], "h": {"id": "C1414689", "name": "C1414689#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [23, 24]}}
{"token": ["T", "lymphocytes", "involved", "during", "the", "genesis", "and", "maintenance", "of", "IBD", ",", "and", "their", "cytokine", "profile", "Crohn's", "disease", "mostly", "C1423842#ent", "<e1>", "cytokines", ")", "is", "different", "from", "that", "in", "C0009324#ent", "<e2>", "mainly", "Th2", "cytokines", ")", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [27, 28]}}
{"token": ["While", "Crohn", "disease", "CD", ")", "has", "been", "clearly", "identified", "as", "a", "C1423842#ent", "<e1>", "inflammation", ",", "the", "immunopathogenesis", "of", "its", "counterpart", "inflammatory", "bowel", "disease", "C0009324#ent", "<e2>", "UC", ")", ",", "remains", "enigmatic", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [23, 24]}}
{"token": ["In", "summary", ",", "this", "study", "reports", "that", "altered", "metabolism", "of", "PlsEtn", "and", "C0812281#ent", "<e1>", "in", "cALD", "may", "be", "corrected", "by", "C2697944#ent", "<e2>", "treatment", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2697944", "name": "C2697944#ent", "pos": [20, 21]}}
{"token": ["Dopamine", "and", "prostaglandin", "A1", "infused", "intravenously", "in", "4", "patients", "with", "the", "C0019212#ent", "<e1>", "in", "1", "patient", "with", "C0022672#ent", "<e2>", "and", "1", "patient", "with", "cortical", "necrosis"], "h": {"id": "C0019212", "name": "C0019212#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022672", "name": "C0022672#ent", "pos": [17, 18]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "differences", "among", "Chinese", "alcoholic", "patients", "with", "esophageal", "cancer", "acute", "pancreatitis", "and", "C0023890#ent", "<e1>", "studying", "the", "genetic", "polymorphisms", "ADH2", ",", "ADH3", ",", "C1412335#ent", "<e2>", ",", "and", "P4502E1", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1412335", "name": "C1412335#ent", "pos": [30, 31]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "differences", "between", "Chinese", "alcoholic", "patients", "with", "C0023890#ent", "<e1>", "and", "acute", "pancreatitis", "studying", "the", "genetic", "polymorphisms", "ADH2", ",", "ADH3", ",", "C1412335#ent", "<e2>", ",", "and", "P4502E1", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412335", "name": "C1412335#ent", "pos": [28, 29]}}
{"token": ["However", ",", "PDGFR", "within", "the", "cultured", "rings", "coupled", "to", "growth", "signalling", "pathways", "as", "C0381163#ent", "<e1>", "caused", "a", "C0213654#ent", "<e2>", "AG1295-sensitive", "activation", "of", "extracellular", "signal-regulated", "kinases", "1", "2", "and", "of", "[3H]-thymidine", "incorporation", "."], "h": {"id": "C0381163", "name": "C0381163#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0213654", "name": "C0213654#ent", "pos": [17, 18]}}
{"token": ["These", "techniques", "have", "been", "applied", "in", "different", "dystonic", "disorders", "primary", "generalized", "dystonia", "dopa-responsive", "dystonia", "C1851920#ent", "<e1>", ")", ",", "as", "well", "as", "focal", "dystonic", "syndromes", "as", "torticollis", ",", "C0154676#ent", "<e2>", "and", "blepharospasm", "."], "h": {"id": "C1851920", "name": "C1851920#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0154676", "name": "C0154676#ent", "pos": [27, 28]}}
{"token": ["To", "investigate", "the", "effect", "of", "C0001486#ent", "<e1>", "expressing", "human", "C0377148#ent", "<e2>", "hBMP-7", ")", "on", "proliferation", "and", "differentiation", "of", "human", "dental", "pulp", "cells"], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [9, 10]}}
{"token": ["The", "remaining", "cells", "were", "placed", "in", "osteogenic", "media", "were", "transfected", "with", "an", "C0001486#ent", "<e1>", "carrying", "the", "cDNA", "for", "C0377148#ent", "<e2>", "BMP-2", ")", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [18, 19]}}
{"token": ["Clinically", ",", "BD", "is", "frequently", "misdiagnosed", "as", "superficial", "basal", "cell", "carcinoma", "patches", "of", "dermatitis", ",", "psoriasis", ",", "C0206139#ent", "<e1>", "actinic", "keratosis", "benign", "lichenoid", "keratosis", ",", "irritated", "seborrheic", "keratosis", "C1367460#ent", "<e2>", "amelanotic", "melanoma", "melanoma", "."], "h": {"id": "C0206139", "name": "C0206139#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1367460", "name": "C1367460#ent", "pos": [28, 29]}}
{"token": ["as", "well", "as", "nononcological", "indications", "(", "e.g.", ",", "acne", ",", "condyloma", "acuminatum", "C0206139#ent", "<e1>", "psoriasis", ",", "vitiligo", ",", "vulval", "lichen", "sclerosus", "C1367460#ent", "<e2>", "and", "verrucae", ")", "."], "h": {"id": "C0206139", "name": "C0206139#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1367460", "name": "C1367460#ent", "pos": [21, 22]}}
{"token": ["Several", "weeks", "after", "excitotoxic", "lesion", "of", "the", "retina", "with", "40", "nmol", "of", "C0022471#ent", "<e1>", "injected", "intravitreally", ",", "only", "C1420342#ent", "<e2>", "transient", "responses", "could", "be", "recorded", "from", "the", "contralateral", "optic", "tectum"], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [18, 19]}}
{"token": ["The", "serum", "uric", "acid", "white", "blood", "cell", "and", "percentage", "of", "lymphocyte", "and", "monocyte", "counts", "were", "numerically", "intermediate", "between", "control", "and", "C0004238#ent", "<e1>", "values", "in", "all", "of", "the", "C0350056#ent", "<e2>", "treatments", "containing", "C0004238#ent", "<e1>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0350056", "name": "C0350056#ent", "pos": [27, 28]}}
{"token": ["Binary", "combinations", "the", "C0035064#ent", "<e1>", "within", "each", "C4085198#ent", "<e2>", "tested", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4085198", "name": "C4085198#ent", "pos": [7, 8]}}
{"token": ["C1414063#ent", "<e1>", "E3", ")", "protected", "the", "E2-E3BP", "subcomplex", "from", "C3538705#ent", "<e2>", "inactivation", "in", "the", "absence", "of", "the", "substrates", "."], "h": {"id": "C1414063", "name": "C1414063#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538705", "name": "C3538705#ent", "pos": [9, 10]}}
{"token": ["The", "above", "results", "suggest", "that", "C0235950#ent", "<e1>", "inhibit", "the", "C1424480#ent", "<e2>", "expression", ",", "while", "zinc", "supplement", "exerts", "much", "improvement", "."], "h": {"id": "C0235950", "name": "C0235950#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424480", "name": "C1424480#ent", "pos": [9, 10]}}
{"token": ["Rats", "treated", "with", "L-arginine", "alone", "or", "in", "combination", "with", "C0038838#ent", "<e1>", "exhibited", "no", "decreases", "in", "C1428360#ent", "<e2>", "after", "TBI", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [15, 16]}}
{"token": ["They", "both", "presented", "during", "early", "childhood", "cataracts", ",", "otitis", "media", "intestinal", "malabsorption", "C0035243#ent", "<e1>", "and", "failure", "to", "C2938208#ent", "<e2>", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2938208", "name": "C2938208#ent", "pos": [17, 18]}}
{"token": ["While", "the", "gastro-intestinal", "bleeding", "the", "initial", "failure", "organ", "occurred", "more", "frequently", "in", "C1704436#ent", "<e1>", "in", "other", "diseases", ",", "heart", "and", "C0264490#ent", "<e2>", "rare", "."], "h": {"id": "C1704436", "name": "C1704436#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [20, 21]}}
{"token": ["C0033216#ent", "<e1>", "was", "capable", "of", "blocking", "the", "C0001640#ent", "<e2>", "platelet", "aggregation", "giving", "an", "antagonistic", "index", "pA2", ",", "of", "5.0", "+", "/-", "0.6", "and", "half", "antagonistic", "concentration", ",", "A2", ",", "of", "10.4", "mumol", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [7, 8]}}
{"token": ["Mammalian", "C1335236#ent", "<e1>", "LPPs", ",", "or", "C1335404#ent", "<e2>", "constitute", "a", "family", "of", "enzymes", "that", "belongs", "to", "a", "phosphatase", "superfamily"], "h": {"id": "C1335236", "name": "C1335236#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1335404", "name": "C1335404#ent", "pos": [6, 7]}}
{"token": ["The", "responsiveness", "of", "ERK", "and", "C1366876#ent", "<e1>", "to", "oridonin", "suggests", "the", "involvement", "of", "these", "C0010536#ent", "<e2>", "in", "this", "apoptotic", "process"], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [14, 15]}}
{"token": ["Preceding", "the", "apoptosis", ",", "strong", "and", "sustained", "activation", "of", "c-jun", "N-terminal", "kinase", "JNK", ")", "and", "C1366876#ent", "<e1>", "was", "observed", ";", "caspase", "inhibitors", "not", "attenuate", "activities", "of", "those", "C0010536#ent", "<e2>", "despite", "significant", "inhibition", "of", "apoptosis", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [27, 28]}}
{"token": ["The", "therapeutic", "values", "glycerol", "on", "heat", "stroke", "be", "related", "to", "the", "C0003289#ent", "<e1>", "action", "on", "cerebral", "edema", "C0151740#ent", "<e2>", "and", "body", "temperature"], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [17, 18]}}
{"token": ["On", "the", "other", "hand", ",", "mucocutaneous", "candidiasis", "a", "prominent", "feature", "of", "the", "C0085859#ent", "<e1>", "characterized", "by", "adrenal", "insufficiency", "C0020626#ent", "<e2>", "and", "mucocutaneous", "candidiasis"], "h": {"id": "C0085859", "name": "C0085859#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0020626", "name": "C0020626#ent", "pos": [18, 19]}}
{"token": ["This", "case", "report", "one", "such", "course", "of", "treatment", "for", "a", "patient", "with", "multiple", "myeloma", "C0015544#ent", "<e1>", "who", "was", "successfully", "treated", "with", "C0066677#ent", "<e2>", "and", "mirtazapine", "."], "h": {"id": "C0015544", "name": "C0015544#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0066677", "name": "C0066677#ent", "pos": [21, 22]}}
{"token": ["Here", ",", "we", "show", "that", "a", "C0949990#ent", "<e1>", "core", "neuronal", "protein-DNA", "interaction", "network", "is", "organized", "into", "two", "C1333522#ent", "<e2>", "modules", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333522", "name": "C1333522#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "the", "etiologies", "and", "associated", "C0014130#ent", "<e1>", "children", "with", "C0011848#ent", "<e2>", "DI", ")", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [10, 11]}}
{"token": ["Focusing", "on", "C1335279#ent", "<e1>", "and", "PRL-2", ",", "high", "levels", "of", "both", "C0086376#ent", "<e2>", "were", "detected", "in", "a", "subset", "of", "pancreatic", "cancer", "cell", "lines", "tumor", "samples", "Western", "blotting", "immunohistochemistry", ",", "respectively", "."], "h": {"id": "C1335279", "name": "C1335279#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Focusing", "on", "PRL-1", "and", "C1335279#ent", "<e1>", ",", "high", "levels", "of", "both", "C0086376#ent", "<e2>", "were", "detected", "in", "a", "subset", "of", "pancreatic", "cancer", "cell", "lines", "tumor", "samples", "Western", "blotting", "immunohistochemistry", ",", "respectively", "."], "h": {"id": "C1335279", "name": "C1335279#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Factors", "associated", "with", "endothelial", "dysfunction", "C0011847#ent", "<e1>", "include", "activation", "of", "C0033634#ent", "<e2>", "overexpression", "of", "growth", "factors", "cytokines", ",", "and", "oxidative", "stress"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [10, 11]}}
{"token": ["C0011847#ent", "<e1>", "induces", "the", "activation", "of", "several", "C0033634#ent", "<e2>", "PKC", ")", "isoforms", "in", "the", "renal", "glomeruli"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [7, 8]}}
{"token": ["Also", "unaffected", "by", "C0011847#ent", "<e1>", "were", "the", "activities", "of", "C0033634#ent", "<e2>", "cAMP-dependent", "protein", "kinase", "calcium-calmodulin", "protein", "kinase"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [9, 10]}}
{"token": ["However", ",", "in", "both", "C4083008#ent", "<e1>", "and", "CIDP", "patients", "the", "C0007820#ent", "<e2>", "was", "altered", ",", "showing", "significant", "narrowing", "of", "the", "velocity", "distribution", "with", "loss", "of", "the", "fastest-", "and", "slowest-conducting", "fibers", "."], "h": {"id": "C4083008", "name": "C4083008#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [10, 11]}}
{"token": ["C1412515#ent", "<e1>", "also", "uses", "l-arginine", "as", "its", "substrate", ",", "and", "C3500855#ent", "<e2>", "expression", "is", "highly", "induced", "in", "a", "murine", "model", "of", "asthma", "."], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3500855", "name": "C3500855#ent", "pos": [10, 11]}}
{"token": ["C0014457#ent", "<e1>", "defines", "a", "distinct", "subgroup", "of", "C1328840#ent", "<e2>", "patients", "with", "increased", "serum", "IgE", "levels", ",", "increased", "numbers", "of", "PBL", "of", "multiple", "lineages", "and", "higher", "mortality", "from", "infectious", "complications"], "h": {"id": "C0014457", "name": "C0014457#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C1328840", "name": "C1328840#ent", "pos": [7, 8]}}
{"token": ["This", "effect", "was", "accompanied", "by", "an", "increase", "in", "the", "concentration", "of", "cyclic", "AMP", "an", "activation", "of", "C0017916#ent", "<e1>", "and", "of", "fructose", "2,6-bisphosphatase", "and", "an", "inactivation", "of", "C0034348#ent", "<e2>", "of", "6-phosphofructo-2-kinase", "."], "h": {"id": "C0017916", "name": "C0017916#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034348", "name": "C0034348#ent", "pos": [26, 27]}}
{"token": ["Some", "enzymes", "of", "glycogenolysis", "(", "C0017916#ent", "<e1>", ",", "phosphoglucomutase", ",", "and", "C0034348#ent", "<e2>", "were", "decreased", "in", "dystrophic", "fibers", "of", "all", "types", "."], "h": {"id": "C0017916", "name": "C0017916#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034348", "name": "C0034348#ent", "pos": [11, 12]}}
{"token": ["In", "both", "species", "PBO", "and", "C3273682#ent", "<e1>", "increased", "relative", "liver", "weight", "and", "whereas", "PBO", "produced", "a", "midzonal", "(", "mouse", ")", "or", "periportal/midzonal", "(", "rat", ")", "hypertrophy", ",", "C3273682#ent", "<e1>", "produced", "a", "C0340279#ent", "<e1>"], "h": {"id": "C3273682", "name": "C3273682#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0340279", "name": "C0340279#ent", "pos": [31, 32]}}
{"token": ["To", "pursue", "our", "study", "of", "the", "intracellular", "localization", "of", "C0299505#ent", "<e1>", "relation", "to", "its", "function", ",", "we", "fused", "C0019562#ent", "<e2>", "to", "the", "green", "fluorescent", "protein", "GFP", ")", "to", "produce", "the", "VHL-GFP", "fusion", "protein"], "h": {"id": "C0299505", "name": "C0299505#ent", "pos": [9, 10]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [18, 19]}}
{"token": ["Our", "data", "raise", "the", "possibility", "that", "the", "immunosuppression", "observed", "during", "C0004030#ent", "<e1>", "results", "in", "part", "from", "C0017641#ent", "<e2>", "NF-kappaB", "inhibition", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017641", "name": "C0017641#ent", "pos": [16, 17]}}
{"token": ["While", "C0084304#ent", "<e1>", "mutants", "are", "deficient", "in", "conjugational", "recombination", "DNA", "repair", "C0268425#ent", "<e2>", "cell", "lines", "hyperrecombination", "."], "h": {"id": "C0084304", "name": "C0084304#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268425", "name": "C0268425#ent", "pos": [11, 12]}}
{"token": ["Sgs1", "belongs", "to", "the", "C0084304#ent", "<e1>", "members", "include", "other", "G-quadruplex", "DNA", "unwinding", "helicases", "such", "as", "human", "C0268425#ent", "<e2>", "human", "Werner's", "syndrome", "helicases"], "h": {"id": "C0084304", "name": "C0084304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268425", "name": "C0268425#ent", "pos": [16, 17]}}
{"token": ["Agranulocytosis", "and", "septicaemia", "developing", "in", "a", "patient", "with", "C0003873#ent", "<e1>", "3", "years", "'", "intermittent", "treatment", "with", "C0700583#ent", "<e2>", ",", "cimetidine", "and", "flucloxacillin", "for", "staphylococcal", "osteomyelitis", "described", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [16, 17]}}
{"token": ["In", "mice", "and", "C.", "elegans", "developmental", "C1418296#ent", "<e1>", "is", "regulated", "by", "the", "C1332391#ent", "<e2>", "proteins", "."], "h": {"id": "C1418296", "name": "C1418296#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332391", "name": "C1332391#ent", "pos": [12, 13]}}
{"token": ["SV40luc", ",", "expressing", "luciferase", "C0669365#ent", "<e1>", ";", "and", "adv.oriP.E1A.oriP.luc", ",", "a", "conditionally", "replicating", "C0001486#ent", "<e2>", ",", "expressing", "both", "luciferase", "and", "E1A", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [13, 14]}}
{"token": ["These", "gene", "expression", "were", "blocked", "by", "C0669365#ent", "<e1>", "expression", "of", "the", "wild-type", "HPV16", "E7", "or", "C0001486#ent", "<e2>", "E1A", "gene", "but", "not", "by", "E7", "or", "E1A", "mutants", "defective", "for", "Rb", "binding", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [15, 16]}}
{"token": ["Ankylosing", "spondylitis", "the", "prototype", "of", "related", "diseases", "commonly", "called", "C0949691#ent", "<e1>", "which", "include", "reactive", "arthritis", "psoriatic", "arthritis", "C0029408#ent", "<e2>", "associated", "with", "inflammatory", "bowel", "diseases", "enteropathic", "arthritis", "and", "undifferentiated", "spondylarthropathies"], "h": {"id": "C0949691", "name": "C0949691#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [17, 18]}}
{"token": ["To", "describe", "various", "morphologic", "patterns", "of", "C0271051#ent", "<e1>", "DME", ")", "demonstrated", "by", "optical", "coherence", "tomography", "C1418661#ent", "<e2>", ")", "and", "correlate", "them", "with", "visual", "acuity"], "h": {"id": "C0271051", "name": "C0271051#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418661", "name": "C1418661#ent", "pos": [15, 16]}}
{"token": ["The", "mechanism", "of", "the", "C0020625#ent", "<e1>", "caused", "by", "other", "drugs", "(", "miconazole", ",", "C0030863#ent", "<e2>", ",", "amphotericin", ",", "vidarabine", ")", "is", "not", "as", "yet", "known", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030863", "name": "C0030863#ent", "pos": [13, 14]}}
{"token": ["Spinal", "and", "bulbar", "muscular", "atrophy", "C1839259#ent", "<e1>", ")", "is", "a", "late-onset", "motor", "neuron", "disease", "by", "proximal", "muscle", "atrophy", "weakness", ",", "C0015644#ent", "<e2>", "and", "bulbar", "involvement", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0015644", "name": "C0015644#ent", "pos": [20, 21]}}
{"token": ["C1522670#ent", "<e1>", "uPA", ")", "gene", "expression", "LLC-PK1", "cells", "induced", "by", "activation", "of", "C0010531#ent", "<e2>", "cAMP-PK", ")", "or", "protein", "kinase", "C", "PK-C", ")", "."], "h": {"id": "C1522670", "name": "C1522670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}}
{"token": ["Induction", "of", "C1522670#ent", "<e1>", "uPA", ")", "in", "response", "to", "either", "reagents", "activating", "C0010531#ent", "<e2>", "cAMP-PK", ")", "or", "the", "calcium", "ion", "phospholipid-dependent", "kinase", "C-kinase", ")", "was", "compared", "in", "the", "LLC-PK1", "and", "T47D", "cell", "lines", "."], "h": {"id": "C1522670", "name": "C1522670#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}}
{"token": ["Insulin", "receptor", "activity", "and", "its", "relationship", "with", "catecholamines", "and", "serotonin", "were", "investigated", "in", "rat", "brain", "using", "C0146951#ent", "<e1>", "extracts", "from", "total", "membranes", "synaptosomes", "and", "choroid", "plexus", "C0271801#ent", "<e2>", "hyperthyroidism", "."], "h": {"id": "C0146951", "name": "C0146951#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0271801", "name": "C0271801#ent", "pos": [26, 27]}}
{"token": ["The", "two", "lysosome-associated", "membrane", "proteins", "C1421418#ent", "<e1>", "and", "LAMP-2", ",", "are", "major", "C0021699#ent", "<e2>", "the", "lysosomes", "."], "h": {"id": "C1421418", "name": "C1421418#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "repairing", "processes", "to", "be", "more", "active", "in", "the", "C1823520#ent", "<e1>", "and", "therefore", "C1708115#ent", "<e2>", "could", "have", "also", "a", "protective", "role", "in", "cerebral", "ischemia"], "h": {"id": "C1823520", "name": "C1823520#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1708115", "name": "C1708115#ent", "pos": [14, 15]}}
{"token": ["In", "both", "cell", "types", "aldosterone-induced", "a", "rapid", "and", "sustained", "3-fold", "induction", "in", "C1979844#ent", "<e1>", "mRNA", "accumulation", "within", "6", "h.", "C2987232#ent", "<e2>", "mRNA", "was", "similarly", "induced", "."], "h": {"id": "C1979844", "name": "C1979844#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987232", "name": "C2987232#ent", "pos": [19, 20]}}
{"token": ["Binding", "capacity", "with", "erythrocyte", "phytohemagglutinin", "in", "these", "cells", "using", "fluorescence-activated", "cell", "sorter", "analysis", "different", ",", "suggesting", "that", "the", "structure", "of", "C0242209#ent", "<e1>", "the", "cell", "surface", "be", "altered", "by", "suppression", "of", "C1417135#ent", "<e2>", "activity", "."], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1417135", "name": "C1417135#ent", "pos": [30, 31]}}
{"token": ["We", "challenge", "this", "preconception", "on", "the", "basis", "of", "a", "review", "of", "several", "important", "risk", "factors", "diseases", ":", "C0001962#ent", "<e1>", "and", "liver", "cirrhosis", "tobacco", "and", "stroke", ",", "C0007222#ent", "<e2>", "and", "lung", "cancer", "and", "oestrogens", "and", "endometrial", "cancer"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [26, 27]}}
{"token": ["Alcohol", "A", "intake", "of", "C0001962#ent", "<e1>", "increases", "blood", "pressure", "serum", "triglyceride", "and", "increases", "mortality", "from", "C0007222#ent", "<e2>"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [15, 16]}}
{"token": ["The", "C1704467#ent", "<e1>", "promoter", "contains", "a", "C1511573#ent", "<e2>", "at", "-1,552", "bp", "upstream", "of", "the", "translation", "start"], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [6, 7]}}
{"token": ["Cytokines", "decreased", "(", "56", "%", ")", "the", "activity", "of", "the", "C1704467#ent", "<e1>", "promoter", "that", "contains", "a", "C1511573#ent", "<e2>", "CRE", ")", "site", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [16, 17]}}
{"token": ["At", "the", "same", "time", ",", "however", ",", "expression", "of", "C1704467#ent", "<e1>", ",", "which", "has", "a", "C1511573#ent", "<e2>", "CRE", ")", ",", "was", "not", "affected", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [15, 16]}}
{"token": ["The", "presence", "of", "C1415975#ent", "<e1>", "anti-parvovirus", "B19", "Ab", "serum", "on", "day", "0", "and", "its", "persistence", "in", "serum", "7", "months", "C1332754#ent", "<e2>", "suggests", "that", "C1415975#ent", "<e1>", "anti-parvovirus", "may", "be", "useful", "in", "prognosis", "of", "parvovirus", "B19", "infection"], "h": {"id": "C1332754", "name": "C1332754#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [3, 4]}}
{"token": ["The", "positive", "inotropism", "induced", "by", "C0029904#ent", "<e1>", "was", "not", "impaired", "by", "C0072918#ent", "<e2>"], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0072918", "name": "C0072918#ent", "pos": [11, 12]}}
{"token": ["The", "clinical", "phenotype", "patients", "with", "C1843003#ent", "<e1>", "a", "continuum", ",", "from", "C1414542#ent", "<e2>", "one", "extreme", "to", "isolated", "C1843003#ent", "<e1>", "to", "myxomatous", "proliferation", "of", "the", "valve", "leaflets"], "h": {"id": "C1414542", "name": "C1414542#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1843003", "name": "C1843003#ent", "pos": [5, 6]}}
{"token": ["Our", "data", "show", "that", "LA", ",", "like", "ADT", ",", "induces", "a", "highly", "significant", ",", "time-", "and", "concentration", "dependent", ",", "increase", "in", "the", "activity", "of", "C0919428#ent", "<e1>", "and", "GST", "in", "C1413014#ent", "<e2>", "astroglial", "cells"], "h": {"id": "C0919428", "name": "C0919428#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1413014", "name": "C1413014#ent", "pos": [29, 30]}}
{"token": ["Taken", "together", ",", "these", "data", "suggest", "that", "heparin", "may", "exert", "its", "antiproliferative", "potential", "by", "slowly", "and", "specifically", "altering", "C1539322#ent", "<e1>", "response", "to", "C1705447#ent", "<e2>", "platelet", "origin"], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705447", "name": "C1705447#ent", "pos": [22, 23]}}
{"token": ["The", "effect", "of", "the", "PL/IM", "430", "inhibitory", "anti-calcium", "pump", "antibody", "compared", "to", "that", "of", "other", "C0001476#ent", "<e1>", "predominantly", "on", "the", "100", "and", "the", "97", "kD", "C0001476#ent", "<e1>", "respectively", "."], "h": {"id": "C0001476", "name": "C0001476#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001476", "name": "C0001476#ent", "pos": [15, 16]}}
{"token": ["Expression", "of", "the", "nuclear", "proto-oncogenes", "C0079068#ent", "<e1>", ",", "c-jun", "and", "c-fos", ",", "are", "indicative", "of", "C0599295#ent", "<e2>", "during", "cellular", "proliferation"], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [15, 16]}}
{"token": ["It", "would", "appear", "that", "elevated", "expression", "of", "conformationally", "inactive", "p53", "and", "of", "high", "levels", "of", "C0079068#ent", "<e1>", "represents", "an", "C0599295#ent", "<e2>", "normal", "uroepithelial", "cells", "carcinogen", "challenge", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [19, 20]}}
{"token": ["The", "use", "of", "cell", "culture", "models", "investigate", "C1413752#ent", "<e1>", "toxicity", "must", "avoid", "the", "use", "of", "potential", "C0035064#ent", "<e2>", "which", "may", "have", "a", "synergistic", "effect", "the", "development", "of", "toxicity", "."], "h": {"id": "C1413752", "name": "C1413752#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [16, 17]}}
{"token": ["The", "above", "observations", "show", "that", "C0010583#ent", "<e1>", "chickens", "did", "not", "develop", "clinical", "C0022104#ent", "<e2>", "in", "the", "presence", "of", "infection", "and", "severe", "immunosuppression", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [12, 13]}}
{"token": ["The", "retroviral", "RNA", "genome", "encodes", "for", "three", "enzymes", "essential", "for", "viral", "replication", "C0917721#ent", "<e1>", "PR", ")", ",", "HIV-1", "reverse", "transcriptase", "RT", ")", "and", "C0917728#ent", "<e2>", "IN", ")", "."], "h": {"id": "C0917721", "name": "C0917721#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0917728", "name": "C0917728#ent", "pos": [23, 24]}}
{"token": ["The", "sequences", "of", "the", "two", "clones", "that", "are", "C1334043#ent", "<e1>", "to", "the", "C1421361#ent", "<e2>", "cDNA", "span", "670", "and", "580", "bp", ",", "respectively", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421361", "name": "C1421361#ent", "pos": [12, 13]}}
{"token": ["A", "C1334043#ent", "<e1>", "ung1", ")", "of", "the", "C1421361#ent", "<e2>", "UNG", ")", "gene", "was", "characterized", "from", "fission", "yeast", "Schizosaccharomyces", "pombe", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421361", "name": "C1421361#ent", "pos": [7, 8]}}
{"token": ["Cytomegalovirus", "gene", "UL114", "a", "C1334043#ent", "<e1>", "of", "mammalian", "C1421361#ent", "<e2>", "UNG", ")", ",", "is", "required", "for", "efficient", "viral", "DNA", "replication"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421361", "name": "C1421361#ent", "pos": [8, 9]}}
{"token": ["We", "believe", "that", "the", "rare", "C4048158#ent", "<e1>", "during", "blood", "donation", "not", "an", "epileptic", "seizure", "but", "in", "fact", "an", "C0039070#ent", "<e2>"], "h": {"id": "C4048158", "name": "C4048158#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039070", "name": "C0039070#ent", "pos": [18, 19]}}
{"token": ["During", "the", "test", ",", "the", "patient", "developed", "C4048158#ent", "<e1>", "as", "well", "as", "C0039070#ent", "<e2>"], "h": {"id": "C4048158", "name": "C4048158#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039070", "name": "C0039070#ent", "pos": [12, 13]}}
{"token": ["This", "primarily", "C0235025#ent", "<e1>", "axonal", "features", "may", "be", "a", "variant", "of", "C0221423#ent", "<e2>", "polyneuropathy", ",", "a", "rarely", "reported", "condition", "in", "pediatric", "patients", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [11, 12]}}
{"token": ["Hepatocyte", "nuclear", "factor", "1B", "HNF1B", ")", "gene", "mutation", "carriers", "have", "a", "systemic", "disease", "by", "congenital", "malformations", "the", "urogenital", "tract", "diabetes", "mellitus", "C0011860#ent", "<e1>", "the", "young", "type", "and", "dysfunction", "of", "the", "liver", "and", "C0700138#ent", "<e2>"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0700138", "name": "C0700138#ent", "pos": [32, 33]}}
{"token": ["Respiratory", "mechanics", "also", "measured", "for", "60", "min", "in", "another", "group", "of", "seven", "patients", "with", "C1412502#ent", "<e1>", "who", "received", "four", "puffs", "of", "C0001927#ent", "<e2>", "."], "h": {"id": "C1412502", "name": "C1412502#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [21, 22]}}
{"token": ["To", "determine", "the", "additive", "effect", "oral", "theophylline", "patients", "with", "stable", "C1412502#ent", "<e1>", "who", "received", "both", "C0001927#ent", "<e2>", "400", "micrograms", ",", "and", "ipratropium", "bromide", "80", "micrograms", ",", "four", "times", "daily", "administered", "with", "a", "metered-dose", "inhaler"], "h": {"id": "C1412502", "name": "C1412502#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [15, 16]}}
{"token": ["Impedance", "measurements", "of", "the", "respiratory", "system", "means", "of", "the", "forced", "oscillation", "technique", "performed", "in", "a", "group", "of", "20", "C1412502#ent", "<e1>", "patients", "before", "and", "after", "inhalation", "of", "0.400", "mg", "C0001927#ent", "<e2>", "."], "h": {"id": "C1412502", "name": "C1412502#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [28, 29]}}
{"token": ["Analysis", "of", "C1412370#ent", "<e1>", "provided", "additional", "evidence", "of", "variability", "within", "the", "C1704945#ent", "<e2>", "family", "."], "h": {"id": "C1412370", "name": "C1412370#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [11, 12]}}
{"token": ["With", "regard", "to", "therapeutic", "endoscopy", "of", "C0333291#ent", "<e1>", "multipolar", "electrocoagulation", "laser", "photocoagulation", "and", "injection", "of", "various", "C0035064#ent", "<e2>", "all", "may", "be", "effective", "and", "beneficial", "."], "h": {"id": "C0333291", "name": "C0333291#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [16, 17]}}
{"token": ["Others", "included", "150", "cases", "of", "C3495439#ent", "<e1>", "which", "36", "cases", "were", "diagnosed", "as", "C0041323#ent", "<e2>", ",", "386", "cases", "as", "fibrocystic", "disease", "42", "cases", "as", "other", "benign", "neoplastic", "diseases"], "h": {"id": "C3495439", "name": "C3495439#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [13, 14]}}
{"token": ["Sustained-release", "C0012373#ent", "<e1>", "alone", "and", "in", "combination", "with", "C0072973#ent", "<e2>", "reduce", "blood", "pressure", "a", "dose", "related", "manner", "and", "is", "well", "tolerated", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072973", "name": "C0072973#ent", "pos": [8, 9]}}
{"token": ["Recent", "discoveries", "of", "parasite", "proteins", "inhibit", "human", "serine", "proteinases", "together", "with", "the", "complete", "genomic", "sequence", "C0949990#ent", "<e1>", "have", "provided", "a", "set", "of", "new", "C0072402#ent", "<e2>", "inhibitors", "from", "more", "primitive", "metazoan", "animals", "such", "as", "nematodes", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [23, 24]}}
{"token": ["C2239905#ent", "<e1>", "is", "known", "to", "be", "mainly", "metabolized", "by", "C1261253#ent", "<e2>", "NAT2", ")", ",", "and", "acetylation", "phenotypes", "(", "rapid", ",", "intermediate", "and", "slow", "acetylator", ")", "correlate", "with", "NAT2*", "genotypes"], "h": {"id": "C2239905", "name": "C2239905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1261253", "name": "C1261253#ent", "pos": [9, 10]}}
{"token": ["Biopsies", "from", "twenty-nine", "malignant", "skin", "tumours", "four", "C0037274#ent", "<e1>", "fourteen", "samples", "of", "normal", "skin", "stained", "for", "cell", "surface", "membrane", "cytoplasmic", "expression", "HLA", "heavy", "chain", "C0806492#ent", "<e2>", "beta", "2", "microglobulin", "by", "use", "of", "the", "immunoperoxidase", "technique", "frozen", "sections", "monoclonal", "antibodies"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0806492", "name": "C0806492#ent", "pos": [24, 25]}}
{"token": ["We", "also", "show", ",", "by", "chromatin", "immunoprecipitation", "that", "C3273424#ent", "<e1>", "is", "recruited", "to", "the", "C0079471#ent", "<e2>", "promoter", "in", "a", "p53-dependent", "manner", ",", "consistent", "with", "role", "in", "promoting", "transcriptional", "initiation"], "h": {"id": "C3273424", "name": "C3273424#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "C0019163#ent", "<e1>", "infection", "alters", "phase", "II", "C3541394#ent", "<e2>", "via", "different", "mechanisms", "than", "those", "modulated", "by", "treatment", "with", "oltipraz", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [8, 9]}}
{"token": ["The", "coenzyme", "properties", "azido-NAD+", "are", "demonstrated", "with", "C0376261#ent", "<e1>", ",", "glutamate", "and", "C3659502#ent", "<e2>", "14", ",", "154", "and", "60", "%", ",", "respectively", ",", "of", "the", "V", "observed", "with", "NAD+", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [12, 13]}}
{"token": ["The", "polymeric", "NAD", "derivatives", "inhibited", "the", "activities", "of", "C0376261#ent", "<e1>", "and", "yeast", "C3659502#ent", "<e2>", "did", "not", "inhibit", "those", "of", "horse", "liver", "alcohol", "and", "malate", "dehydrogenases"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [12, 13]}}
{"token": ["In", "the", "meantime", "two", "large", "double", "blind", "randomized", "trials", "ISAM", "and", "GISSI", ")", "could", "demonstrate", "a", "reduction", "in", "hospital", "mortality", "C0027051#ent", "<e1>", "especially", "by", "early", "treatment", "C0038418#ent", "<e2>"], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [20, 21]}, "relation": "may_be_treated_by", "t": {"id": "C0038418", "name": "C0038418#ent", "pos": [26, 27]}}
{"token": ["The", "results", "are", "in", "accord", "with", "two", "previous", "trials", "with", "different", "pharmacologic", "agents", "indicate", "that", "modification", "of", "lipoprotein", "levels", "C0017245#ent", "<e1>", "reduces", "the", "incidence", "of", "C0010068#ent", "<e2>", "men", "with", "dyslipidemia", "."], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [25, 26]}}
{"token": ["Step-wise", "testing", "includes", "a", "complete", "blood", "cell", "count", "an", "assessment", "of", "the", "prothrombin", "time", "activated", "partial", "thromboplastin", "time", "iron", "profile", "serum", "creatinine", "C1336679#ent", "<e1>", "level", ",", "followed", "by", "C1366370#ent", "<e2>", "level", ",", "von", "Willebrand", "factor", "antigen", "ristocetin", "cofactor", "followed", "by", "consideration", "of", "platelet", "aggregation", "studies"], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [28, 29]}}
{"token": ["Another", "large", "multicenter", "trial", "demonstrated", "that", "celecoxib", "200", "mg", "BTD", "and", "400", "mg", "C1332410#ent", "<e1>", "is", "as", "effective", "as", "naproxen", "500", "mg", "C1332410#ent", "<e1>", "in", "patients", "with", "C0038013#ent", "<e1>", "RA", ")", "."], "h": {"id": "C1332410", "name": "C1332410#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [27, 28]}}
{"token": ["Basal", "digital", "pressure", "(", "BDP", ")", ",", "digital", "to", "contralateral", "brachial", "index", "(", "C0031404#ent", "<e1>", ")", ",", "and", "change", "in", "digital", "pressure", "access", "compression", "C1413827#ent", "<e2>", ")", "were", "determined", "."], "h": {"id": "C0031404", "name": "C0031404#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413827", "name": "C1413827#ent", "pos": [24, 25]}}
{"token": ["C3697670#ent", "<e1>", "an", "unusual", "C0026650#ent", "<e2>"], "h": {"id": "C3697670", "name": "C3697670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [4, 5]}}
{"token": ["We", "examined", "peripheral", "blood", "mononuclear", "cells", "30", "healthy", "subjects", "50", "subjects", "with", "C0085580#ent", "<e1>", "in", "whom", "C1413931#ent", "<e2>", "genotype", "was", "determined", ",", "before", "and", "after", "15", "days", "of", "treatment", "with", "different", "antihypertensive", "drugs"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413931", "name": "C1413931#ent", "pos": [16, 17]}}
{"token": ["It", "is", "conceivable", "that", "the", "expression", "of", "C0599295#ent", "<e1>", "play", "a", "crucial", "role", "in", "C0206146#ent", "<e2>", "."], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0206146", "name": "C0206146#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "C1413599#ent", "<e1>", "deficiency", "compounds", "the", "antibody", "deficiency", "C4284230#ent", "<e2>", ",", "and", "reinforces", "the", "ostensible", "role", "of", "C1413599#ent", "<e1>", "in", "innate", "immunity"], "h": {"id": "C4284230", "name": "C4284230#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413599", "name": "C1413599#ent", "pos": [4, 5]}}
{"token": ["To", "date", ",", "only", "10", "cases", "of", "C0040021#ent", "<e1>", "patients", "with", "C0022661#ent", "<e2>", "been", "reported", "."], "h": {"id": "C0040021", "name": "C0040021#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [11, 12]}}
{"token": ["We", "report", "an", "additional", "case", "of", "C0040021#ent", "<e1>", "a", "41-year-old", "man", "who", "presented", "with", "C0022661#ent", "<e2>", "pulmonary", "tuberculosis"], "h": {"id": "C0040021", "name": "C0040021#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [14, 15]}}
{"token": ["C0034414#ent", "<e1>", ",", "verapamil", ",", "nitrendipine", ",", "amiodaron", ",", "propafenone", ",", "C0006938#ent", "<e2>", ",", "spironolactone", "decrease", "renal", "clearance", "digoxin", ",", "and", "amilorid/triamteren", "lower", "the", "extrarenal", "clearance", "of", "this", "drug", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [11, 12]}}
{"token": ["The", "long-term", "behavioral", "outcome", "subsequent", "to", "prenatal", "exposure", "to", "C0031507#ent", "<e1>", "was", "examined", "in", "an", "animal", "model", "the", "Fetal", "C0020209#ent", "<e2>"], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020209", "name": "C0020209#ent", "pos": [19, 20]}}
{"token": ["Specifically", ",", "fetal", "exposure", "to", "C0031507#ent", "<e1>", "is", "linked", "to", "fetal", "C0020209#ent", "<e2>", "humans", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020209", "name": "C0020209#ent", "pos": [11, 12]}}
{"token": ["The", "effectiveness", "of", "the", "compounds", "on", "the", "C0376622#ent", "<e1>", "mediated", "calcein-AM", "efflux", ",", "ATPase", "activity", "and", "C0009262#ent", "<e2>", "proven", "by", "microplate", "assays", "and", "flow", "cytometry", "recombinant", "and", "control", "cell", "lines"], "h": {"id": "C0376622", "name": "C0376622#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [16, 17]}}
{"token": ["P-glycoprotein", "(", "PGP", ")", ",", "a", "drug", "exporter", "by", "C0376622#ent", "<e1>", ",", "exports", "both", "paclitaxel", "and", "C0009262#ent", "<e2>", "."], "h": {"id": "C0376622", "name": "C0376622#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "beta-MCA", "on", "organelle", "lipids", "and", "their", "intracellular", "transport", "may", "differ", "from", "those", "of", "C1415587#ent", "<e1>", ",", "presumably", "because", "of", "the", "C0003277#ent", "<e2>", "and", "cytoprotective", "effects", "T", "beta-MCA", "."], "h": {"id": "C1415587", "name": "C1415587#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003277", "name": "C0003277#ent", "pos": [23, 24]}}
{"token": ["A", "TNFR2-specific", "mutein", "down-regulates", "TNFR1", "in", "glomerular", "EC", ",", "up-regulates", "C1363982#ent", "<e1>", "and", "C1332433#ent", "<e2>", "in", "tubular", "cells", "and", "induces", "phosphorylation", "of", "C1332433#ent", "<e2>", "."], "h": {"id": "C1363982", "name": "C1363982#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332433", "name": "C1332433#ent", "pos": [13, 14]}}
{"token": ["Administration", "of", "cyclic", "AMP", "C0085387#ent", "<e1>", "ammonium", "chloride", "to", "correct", "the", "C0085682#ent", "<e2>", "or", "the", "blunted", "response", "to", "PTH", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085682", "name": "C0085682#ent", "pos": [11, 12]}}
{"token": ["The", "LTA", "26Asn", "variant", "predicted", "higher", "adjusted", "C0007820#ent", "<e1>", "risk", "(", "hazard", "ratio", "HR", "1.33", "for", "each", "additional", "copy", "of", "C1704658#ent", "<e2>", "95", "%", "confidence", "interval", "to", "1.55", ";", "P", "=", "0.0003", ")", "."], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704658", "name": "C1704658#ent", "pos": [20, 21]}}
{"token": ["C1332082#ent", "<e1>", "known", "to", "C0599874#ent", "<e2>", "phospholipids", "without", "preceding", "action", "of", "phospholipases", "A2", "PLA2", ")", "."], "h": {"id": "C1332082", "name": "C1332082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0599874", "name": "C0599874#ent", "pos": [4, 5]}}
{"token": ["By", "contrast", ",", "C0919442#ent", "<e1>", "and", "Syna", "expression", "unaltered", "in", "C1415016#ent", "<e2>", "mutants", ",", "suggesting", "that", "Gcm1-positive", "cells", "are", "not", "required", "for", "the", "induction", "of", "the", "other", "chorion", "layers", "."], "h": {"id": "C0919442", "name": "C0919442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415016", "name": "C1415016#ent", "pos": [10, 11]}}
{"token": ["Processing", "of", "Japanese", "encephalitis", "JE", ")", "virus", "non-structural", "(", "NS", ")", "C0086376#ent", "<e1>", "expressed", "by", "recombinant", "vaccinia", "viruses", "analysed", "to", "characterize", "the", "responsible", "C1947941#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [23, 24]}}
{"token": ["The", "impact", "of", "carvedilol", "on", "the", "survival", "of", "patients", "with", "severe", "C0018801#ent", "<e1>", "examined", "in", "the", "C0054836#ent", "<e2>", "Prospective", "Randomized", "Cumulative", "Survival", "(", "COPERNICUS", ")", "trial", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0054836", "name": "C0054836#ent", "pos": [16, 17]}}
{"token": ["We", "show", "that", "the", "small", "C0018296#ent", "<e1>", "Rab7", "mainly", "associates", "with", "early", "and", "intermediate", "stage", "and", "C1624014#ent", "<e2>", "to", "intermediate", "and", "mature", "melanosomes", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1624014", "name": "C1624014#ent", "pos": [16, 17]}}
{"token": ["Both", "drugs", "beneficially", "influenced", "nocturnal", "symptoms", ";", "the", "effects", "of", "C0054201#ent", "<e1>", "were", "stronger", "than", "those", "of", "C0052944#ent", "<e2>", "."], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0052944", "name": "C0052944#ent", "pos": [17, 18]}}
{"token": ["Chlorpromazine", ",", "a", "C3536886#ent", "<e1>", "was", "shown", "to", "induce", "DnaK", "and", "C1415782#ent", "<e2>", "major", "heat", "shock", "proteins", "E.", "coli"], "h": {"id": "C3536886", "name": "C3536886#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415782", "name": "C1415782#ent", "pos": [11, 12]}}
{"token": ["We", "tested", "these", "ratios", "in", "patients", "with", "C0023890#ent", "<e1>", "and", "non", "cirrhotic", "of", "C0020541#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020541", "name": "C0020541#ent", "pos": [13, 14]}}
{"token": ["Hepatitis", "C", "a", "widespread", "chronic", "liver", "disease", "to", "C0023890#ent", "<e1>", "and", "to", "the", "complications", "of", "C0020541#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020541", "name": "C0020541#ent", "pos": [15, 16]}}
{"token": ["Formoterol", "AUC", "and", "C(max", ")", "were", "13", "%", "and", "39", "%", "lower", "after", "C1276807#ent", "<e1>", "pMDI", "versus", "C0060657#ent", "<e2>", "DPI", "."], "h": {"id": "C1276807", "name": "C1276807#ent", "pos": [13, 14]}, "relation": "has_constitutional_part", "t": {"id": "C0060657", "name": "C0060657#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "nordihydroguaiaretic", "acid", "a", "C0085385#ent", "<e1>", "was", "able", "to", "block", "the", "naloxone-induced", "contraction", "following", "exposure", "to", "C0525773#ent", "<e2>", "or", "U50", "-", "488H", "if", "injected", "either", "before", "or", "after", "the", "opioid", "agonist"], "h": {"id": "C0085385", "name": "C0085385#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0525773", "name": "C0525773#ent", "pos": [18, 19]}}
{"token": ["The", "temporal", "modulation", "transfer", "function", "(", "temporal", "C1417400#ent", "<e1>", ")", "was", "measured", "in", "normal", "controls", "in", "patients", "with", "C0012634#ent", "<e2>", "optic", "neuritis", "amblyopia", "."], "h": {"id": "C1417400", "name": "C1417400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["Expression", "of", "modified", "sdhB", "together", "with", "C1419906#ent", "<e1>", "in", "Escherichia", "coli", "to", "C0221406#ent", "<e2>", "of", "active", "His6-tagged", "L-serine", "dehydratase", "."], "h": {"id": "C1419906", "name": "C1419906#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [12, 13]}}
{"token": ["Two", "additional", "C1562036#ent", "<e1>", "perhexilene", "and", "diltiazem", ",", "and", "three", "calmodulin", "antagonists", "W-7", ",", "C0033229#ent", "<e2>", ",", "and", "trifluoperazine", ",", "were", "also", "tested", "in", "the", "U46619-induced", "thrombotic", "sudden", "death", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033229", "name": "C0033229#ent", "pos": [14, 15]}}
{"token": ["The", "positive", "inotropic", "effect", "at", "1", "Hz", ")", "was", "inhibited", "by", "C1562036#ent", "<e1>", "verapamil", "or", "C0033229#ent", "<e2>", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033229", "name": "C0033229#ent", "pos": [15, 16]}}
{"token": ["Previous", "studies", "have", "established", "that", "LY231514", "and", "its", "synthetic", "gamma-polyglutamates", "C3890215#ent", "<e1>", "and", "glu5", ")", "exert", "potent", "inhibition", "against", "C0040085#ent", "<e2>", "TS", ")", "."], "h": {"id": "C3890215", "name": "C3890215#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040085", "name": "C0040085#ent", "pos": [19, 20]}}
{"token": ["The", "C0020615#ent", "<e1>", "effect", "of", "oral", "insulin", "capsules", "coated", "with", "pH-dependent", "Eudragit", "C3274824#ent", "<e2>", "and", "containing", "various", "absorption", "promoters", "studied", "in", "hyperglycemic", "beagle", "dogs", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3274824", "name": "C3274824#ent", "pos": [12, 13]}}
{"token": ["woc", "mutants", "displayed", "normal", "telomeric", "accumulations", "of", "both", "HP1", "and", "HOAP", ",", "and", "mutations", "in", "C1332670#ent", "<e1>", ",", "Su(var)205", ",", "atm", ",", "and", "C1419239#ent", "<e2>", "did", "not", "affect", "Woc", "localization", "polytene", "chromosome", "telomeres", "."], "h": {"id": "C1332670", "name": "C1332670#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419239", "name": "C1419239#ent", "pos": [23, 24]}}
{"token": ["The", "purified", "C0919466#ent", "<e1>", "in", "a", "baculovirus", "system", "a", "potent", "C1333536#ent", "<e2>", "a", "variety", "of", "cells", ",", "including", "human", "endothelial", "cells"], "h": {"id": "C0919466", "name": "C0919466#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333536", "name": "C1333536#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "argue", "that", "C3495801#ent", "<e1>", "signaling", "activates", "target", "gene", "expression", "by", "overcoming", "the", "chromatin", "barrier", "by", "C1335840#ent", "<e2>", "and", "ACF1", "."], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335840", "name": "C1335840#ent", "pos": [17, 18]}}
{"token": ["The", "C2827469#ent", "<e1>", "possesses", "NAD(P)H", "oxidase", "that", "can", "generate", "C0038838#ent", "<e2>", ",", "inimical", "to", "the", "bioactivity", "of", "endothelial", "NO"], "h": {"id": "C2827469", "name": "C2827469#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [9, 10]}}
{"token": ["No", "such", "increase", "in", "C1412841#ent", "<e1>", "and", "NK", "activities", "was", "seen", "with", "effusion", "C0024054#ent", "<e2>", "of", "patients", "who", "had", "no", "clinical", "benefit", "from", "i.pl", "."], "h": {"id": "C1412841", "name": "C1412841#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024054", "name": "C0024054#ent", "pos": [13, 14]}}
{"token": ["injection", "of", "OK432", "induced", "or", "enhanced", "C1412841#ent", "<e1>", "and", "NK", "activities", "of", "effusion", "large", "granular", "lymphocytes", "(", "C0024054#ent", "<e2>", ")", "in", "patients", "who", "showed", "a", "reduction", "or", "disappearance", "of", "effusion", "tumor", "cells"], "h": {"id": "C1412841", "name": "C1412841#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024054", "name": "C0024054#ent", "pos": [17, 18]}}
{"token": ["Anemia", ",", "C0040034#ent", "<e1>", ",", "jaundice", ",", "hepatomegaly", ",", "and", "C0242528#ent", "<e2>", "within", "2", "weeks", "of", "admission", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242528", "name": "C0242528#ent", "pos": [10, 11]}}
{"token": ["Finally", ",", "in", "those", "children", "with", "cholestasis", ",", "high", "serum", "bile", "acids", "low", "gamma", "glutamyltranspeptidase", "activity", "analysis", "of", "mutation", "in", "C1335222#ent", "<e1>", "and", "bile", "salt", "export", "pump", "genes", "lead", "to", "the", "diagnosis", "of", "progressive", "C0008372#ent", "<e2>", "from", "bile", "salt", "export", "pump", "FIC1", "deficiency"], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0008372", "name": "C0008372#ent", "pos": [34, 35]}}
{"token": ["Despite", "similar", "levels", "of", "FIC1", "protein", "expression", ",", "Byler", "disease", "C1335222#ent", "<e1>", "mutants", "did", "not", "activate", "BSEP", ",", "whereas", "benign", "recurrent", "C0008372#ent", "<e2>", "mutants", "partially", "activated", "BSEP", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008372", "name": "C0008372#ent", "pos": [21, 22]}}
{"token": ["Peroxisome", "proliferators", "ubiquitous", "rodent", "hepatocarcinogens", ",", "known", "to", "modulate", "the", "activities", "of", "xenobiotic-metabolising", "C3540790#ent", "<e1>", "such", "as", "glutathione", "S-transferases", "GST", ")", "and", "C0020364#ent", "<e2>", "cytochrome", "P-450", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020364", "name": "C0020364#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "when", "we", "measured", "activities", "of", "certain", "liver", "drug", "C3540790#ent", "<e1>", ",", "it", "was", "found", "that", "cimetidine", "significantly", "inhibited", "C0020364#ent", "<e2>", "aminopyrine-N-demethylase", "by", "43", "%", "and", "65", "%", ",", "respectively", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020364", "name": "C0020364#ent", "pos": [21, 22]}}
{"token": ["Adding", "a", "nucleic", "acid", "test", "C0124604#ent", "<e1>", ")", "for", "HBV", "DNA", "with", "existing", "C2347281#ent", "<e2>", "for", "HIV-1", "and", "HCV", "RNA", "would", "further", "improve", "blood", "safety", "blood", "screening", "efficiency", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2347281", "name": "C2347281#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "we", "examined", "the", "regulation", "of", "C1332119#ent", "<e1>", "function", "by", "the", "ErbB3/4", "ligand", "heregulin", "(", "C1455836#ent", "<e2>", ")", "."], "h": {"id": "C1332119", "name": "C1332119#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1455836", "name": "C1455836#ent", "pos": [17, 18]}}
{"token": ["Our", "findings", "suggest", "that", "C1332119#ent", "<e1>", ",", "by", "linking", "C1455836#ent", "<e2>", "activation", "of", "membrane", "receptors", "E2F", "gene", "activity", ",", "may", "be", "a", "downstream", "modulator", "of", "the", "effects", "of", "C1455836#ent", "<e2>", "on", "cell", "cycle", "progression", "."], "h": {"id": "C1332119", "name": "C1332119#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1455836", "name": "C1455836#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "C0215638#ent", "<e1>", "is", "effective", "for", "C0028734#ent", "<e2>", "in", "patients", "with", "prostatic", "hyperplasia"], "h": {"id": "C0215638", "name": "C0215638#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028734", "name": "C0028734#ent", "pos": [9, 10]}}
{"token": ["Sotos", "syndrome", "also", "known", "as", "C0175695#ent", "<e1>", "is", "a", "rare", "growth", "disorder", "described", "by", "C2698423#ent", "<e2>", "and", "colleagues", "in", "1964", "."], "h": {"id": "C0175695", "name": "C0175695#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C2698423", "name": "C2698423#ent", "pos": [14, 15]}}
{"token": ["Promising", "attempts", "are", "currently", "made", "to", "inhibit", "CK-dependent", "cell", "recruitment", "to", "lesion", "by", "using", "neutralizing", "antibodies", "C1564139#ent", "<e1>", "viral", "and", "C1511610#ent", "<e2>", "receptor", "antagonists"], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1511610", "name": "C1511610#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "C1833296#ent", "<e1>", "showed", "a", "direct", "effect", "on", "C0023899#ent", "<e2>", "extracellular", "GSH", "content", "in", "anesthetized", "rats", "."], "h": {"id": "C1833296", "name": "C1833296#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["There", "is", "now", "extensive", "experience", "in", "the", "use", "of", "several", "of", "the", "low-molecular-weight", "heparins", "particularly", "C0206461#ent", "<e1>", "and", "enoxaparin", ",", "in", "the", "management", "of", "patients", "with", "C0002965#ent", "<e2>"], "h": {"id": "C0206461", "name": "C0206461#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [26, 27]}}
{"token": ["A", "mutant", "alpha", "subunit", "the", "Gs", "gene", "designated", "C1706339#ent", "<e1>", ",", "which", "results", "in", "C0669365#ent", "<e2>", "activation", "of", "adenylyl", "cylcase", "has", "been", "described", "in", "a", "subset", "of", "GH", "cell", "adenomas"], "h": {"id": "C1706339", "name": "C1706339#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}}
{"token": ["These", "mutations", ",", "named", "C1706339#ent", "<e1>", "for", "Gs", "protein", "cause", "the", "C0669365#ent", "<e2>", ",", "hormone-independent", ",", "activation", "of", "adenylyl", "cyclase", "consequent", "overproduction", "of", "cAMP", ",", "that", "is", "mitogenic", "in", "somatotropes", "."], "h": {"id": "C1706339", "name": "C1706339#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["Patients", "with", "meralgia", "paresthetica", "MP", ")", "usually", "experience", "not", "only", "C0030554#ent", "<e1>", "and", "decreased", "tactile", "sensation", ",", "but", "also", "C0392699#ent", "<e2>", "the", "distribution", "of", "the", "lateral", "femoral", "cutaneous", "nerve", "LFCN", ")", "."], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0392699", "name": "C0392699#ent", "pos": [19, 20]}}
{"token": ["Complaints", "of", "motor", "abnormalities", "by", "myelopathy", "may", "include", "sudden", "weakness", "paralysis", ",", "clumsiness", ",", "fatigability", ";", "sensory", "complaints", "as", "C0030554#ent", "<e1>", ",", "numbness", ",", "deadness", ",", "C0392699#ent", "<e2>", ",", "and", "bladder", "symptoms", "also", "characteristic", "."], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0392699", "name": "C0392699#ent", "pos": [26, 27]}}
{"token": ["Our", "mutational", "studies", "demonstrated", "that", "a", "short", "C-terminal", "alpha-helix", "of", "C1823172#ent", "<e1>", "is", "required", "for", "interaction", "with", "C1823173#ent", "<e2>", "and", "for", "enzyme", "activity"], "h": {"id": "C1823172", "name": "C1823172#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1823173", "name": "C1823173#ent", "pos": [17, 18]}}
{"token": ["C0524735#ent", "<e1>", "(", "DPA", ")", "is", "an", "C0003286#ent", "<e2>", ",", "which", "has", "been", "successfully", "used", "in", "the", "treatment", "of", "several", "types", "of", "epilepsy", "."], "h": {"id": "C0524735", "name": "C0524735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [7, 8]}}
{"token": ["Patients", "with", "C0010346#ent", "<e1>", "experience", "several", "non-digestive", "complications", "including", "C0026848#ent", "<e2>"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [9, 10]}}
{"token": ["Superfusion", "with", "C1413043#ent", "<e1>", "+", "-free", "medium", "containing", "3.8", "mM", "C1333909#ent", "<e2>", "+", "reversibly", "abolished", "all", "effects", "of", "KA", "administration", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [10, 11]}}
{"token": ["The", "activity", "of", "the", "reconstituted", "enzyme", "increased", "in", "the", "order", "of", "Co2", "+", "less", "than", "Mn2", "+", "less", "than", "C1413043#ent", "<e1>", "+", "less", "than", "C1333909#ent", "<e2>", "+", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [24, 25]}}
{"token": ["During", "stepwise", "increases", "in", "the", "methotrexate", "concentration", "in", "culture", "medium", "we", "selected", "Chinese", "hamster", "ovary", "cells", "contained", "elevated", "C3853636#ent", "<e1>", "levels", "which", "were", "proportional", "to", "the", "number", "of", "C1333216#ent", "<e2>", "i.e.", ",", "gene", "amplification", "."], "h": {"id": "C3853636", "name": "C3853636#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333216", "name": "C1333216#ent", "pos": [28, 29]}}
{"token": ["C1413702#ent", "<e1>", "binding", "was", "confirmed", "for", "all", "loci", "supported", "by", "multiple", "C1865138#ent", "<e2>", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [11, 12]}}
{"token": ["However", ",", "since", "the", "C0221333#ent", "<e1>", "persisted", "despite", "the", "remission", "of", "minimal", "change", "C1704321#ent", "<e2>", "it", "appears", "that", "at", "least", "his", "nephrosis", "was", "incidental", "."], "h": {"id": "C0221333", "name": "C0221333#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [13, 14]}}
{"token": ["Delivery", "of", "C1823619#ent", "<e1>", "increased", "liver", "mass", "mice", "but", "did", "not", "stimulate", "growth", "of", "C0669372#ent", "<e2>", "in", "vitro", "unless", "LSECs", "were", "also", "present", "in", "the", "culture", "."], "h": {"id": "C1823619", "name": "C1823619#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [14, 15]}}
{"token": ["C0534191#ent", "<e1>", "also", "has", "therapeutic", "activity", "bleeding", "in", "platelet", "function", "disorders", "as", "C0040015#ent", "<e2>", "thrombocytopenia", "."], "h": {"id": "C0534191", "name": "C0534191#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040015", "name": "C0040015#ent", "pos": [12, 13]}}
{"token": ["An", "established", "on-label", "indication", "for", "the", "use", "of", "C0534191#ent", "<e1>", "is", "given", "in", "patients", "with", "C0040015#ent", "<e2>", "refractoriness", "to", "transfusions", "of", "platelet", "concentrates", "."], "h": {"id": "C0534191", "name": "C0534191#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0040015", "name": "C0040015#ent", "pos": [15, 16]}}
{"token": ["This", "showed", "that", "weekly", "use", "of", "C0001975#ent", "<e1>", ",", "and", "frequency", "of", "use", "of", "C0051772#ent", "<e2>", "cigarettes", "were", "significant", "predictors", "of", "BAI", "score", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051772", "name": "C0051772#ent", "pos": [14, 15]}}
{"token": ["The", "disruption", "of", "brightness", "discrimination", "C1418873#ent", "<e1>", "was", "not", "reversed", "by", "C0008286#ent", "<e2>", ",", "haloperidol", ",", "diazepam", ",", "propranolol", "or", "apomorphine", "at", "doses", "which", "reduced", "the", "locomotor", "stimulation", "by", "C1418873#ent", "<e1>", "."], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [11, 12]}}
{"token": ["The", "technique", "is", "illustrated", "for", "three", "acetylcholine", "channel", "binding", "compounds", "the", "hallucinogen", "phencyclidine", "C1418873#ent", "<e1>", ")", "and", "the", "antipsychotic", "agents", "C0008286#ent", "<e2>", "and", "trifluoperazine", "."], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [20, 21]}}
{"token": ["Additional", "analysis", "of", "the", "bone", "marrow", "NQO1-null", "mice", "revealed", "that", "loss", "of", "C0919428#ent", "<e1>", "alters", "the", "intracellular", "redox", "status", "of", "accumulation", "of", "C0068355#ent", "<e2>", ",", "cofactors", "for", "C0919428#ent", "<e1>", "."], "h": {"id": "C0919428", "name": "C0919428#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0068355", "name": "C0068355#ent", "pos": [22, 23]}}
{"token": ["These", "results", "suggested", "that", "loss", "of", "C0919428#ent", "<e1>", "activity", "alters", "the", "intracellular", "redox", "status", "increasing", "the", "concentration", "of", "C0068355#ent", "<e2>", "This", "leads", "to", "a", "reduction", "in", "pyridine", "nucleotide", "synthesis", "reduced", "glucose", "and", "fatty", "acid", "metabolism", "."], "h": {"id": "C0919428", "name": "C0919428#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0068355", "name": "C0068355#ent", "pos": [18, 19]}}
{"token": ["Dicoumarol", "is", "a", "widely", "used", "potent", "competitive", "inhibitor", "of", "C0919428#ent", "<e1>", "enzymatic", "activity", "which", "competes", "with", "C0068355#ent", "<e2>", "for", "binding", "to", "C0919428#ent", "<e1>", "."], "h": {"id": "C0919428", "name": "C0919428#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0068355", "name": "C0068355#ent", "pos": [16, 17]}}
{"token": ["In", "10", "patients", "with", "C3489393#ent", "<e1>", "effect", "of", "metoclopramide", "bromide", "C0025853#ent", "<e2>", "with", "placebo", ",", "was", "studied", "by", "the", "double", "blind", "method"], "h": {"id": "C3489393", "name": "C3489393#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [10, 11]}}
{"token": ["The", "sensitivity", "of", "this", "technique", "coupled", "with", "the", "minute", "volumes", "biological", "sample", "renders", "it", "of", "potential", "utility", "for", "C2699241#ent", "<e1>", "quantitation", "in", "a", "variety", "of", "C1290884#ent", "<e2>"], "h": {"id": "C2699241", "name": "C2699241#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [25, 26]}}
{"token": ["The", "second", "cluster", "of", "C0017337#ent", "<e1>", "is", "the", "glutathione", "S-transferase-A3-like", "genes", "which", "include", "C0219300#ent", "<e2>", "aldehyde", "oxidase"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0219300", "name": "C0219300#ent", "pos": [13, 14]}}
{"token": ["Despite", "the", "fact", "that", "the", "genetic", "defect", "not", "known", ",", "the", "C2699120#ent", "<e1>", "rat", "is", "widely", "used", "for", "research", "in", "C0154860#ent", "<e2>"], "h": {"id": "C2699120", "name": "C2699120#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0154860", "name": "C0154860#ent", "pos": [20, 21]}}
{"token": ["A", "previous", "report", "has", "suggested", "that", "axon", "guidance", "in", "response", "to", "C1334908#ent", "<e1>", "requires", "cAMP", "production", "mediated", "by", "soluble", "C1382029#ent", "<e2>", "sAC", ")", "."], "h": {"id": "C1334908", "name": "C1334908#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [19, 20]}}
{"token": ["High-glucose-induced", "stimulation", "of", "Ca2", "+", "uptake", "was", "blocked", "by", "pertussis", "toxin", "SQ-22536", "(", "adenylate", "cyclase", "inhibitor", ",", "C1312095#ent", "<e1>", ",", "neomycin", "and", "U-73122", "(", "C0597220#ent", "<e2>", ",", "and", "staurosporine", "and", "bisindolylmaleimide", "I", "protein", "kinase", "C", "inhibitors", "."], "h": {"id": "C1312095", "name": "C1312095#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0597220", "name": "C0597220#ent", "pos": [24, 25]}}
{"token": ["The", "change", "in", "5", "micromol/L", "ADP-induced", "platelet", "aggregation", "subjects", "with", "the", "C1707179#ent", "<e1>", "genotype", "was", "greater", "than", "that", "in", "subjects", "with", "the", "C1707182#ent", "<e2>"], "h": {"id": "C1707179", "name": "C1707179#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1707182", "name": "C1707182#ent", "pos": [22, 23]}}
{"token": ["Parameters", "of", "IgE-mediated", "reactivity", "including", "immediate-type", "skin", "test", "reactivity", ",", "total", "serum", "C1260880#ent", "<e1>", "specific", "serum", "and", "C1260880#ent", "<e1>", "and", "C1306759#ent", "<e1>", "were", "also", "assessed", "in", "these", "patients", "."], "h": {"id": "C1260880", "name": "C1260880#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "the", "C1413247#ent", "<e1>", "model", "is", "the", "most", "robust", "C1414170#ent", "<e2>", "to", "population", "cycles", "caused", "by", "species", "interactions", "."], "h": {"id": "C1413247", "name": "C1413247#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414170", "name": "C1414170#ent", "pos": [10, 11]}}
{"token": ["Multiple", "sequence", "alignments", "that", "C0026267#ent", "<e1>", "is", "closely", "related", "to", "eukaryotic", "PPases", "whereas", "C1843003#ent", "<e2>", "shows", "highest", "homologies", "to", "bacterial", "PPases", "."], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C1843003", "name": "C1843003#ent", "pos": [13, 14]}}
{"token": ["eNOS-/-", "mice", "showed", "decreased", "cerebrovascular", "reactivities", "NG-nitro-L-arginine", "methyl", "ester", "L-NAME", ")", ",", "C0675766#ent", "<e1>", "acetylcholine", "(", "Ach", ")", ",", "and", "C0669516#ent", "<e2>", "."], "h": {"id": "C0675766", "name": "C0675766#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [20, 21]}}
{"token": ["Ratio", "of", "C0684275#ent", "<e1>", "A", "to", "C0019069#ent", "<e2>", "4.2:1", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [6, 7]}}
{"token": ["There", "were", "25", "patients", "with", "C0684275#ent", "<e1>", "five", "with", "C0019069#ent", "<e2>", "HIV", "status", "CD4", "count", "recorded", ",", "and", "Knee", "Society", "scores", "determined", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [9, 10]}}
{"token": ["We", "investigated", "whether", "serial", "determination", "of", "C1706005#ent", "<e1>", "to", "HCV", "core", "protein", "HCV", "IgM", "may", "be", "useful", "to", "identify", "acute", "hepatitis", "C", "C2698419#ent", "<e2>", ")", "and", "to", "distinguish", "this", "disease", "from", "reactivation", "of", "chronic", "hepatitis", "C", "r-CHC", ")", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2698419", "name": "C2698419#ent", "pos": [22, 23]}}
{"token": ["To", "evaluate", "the", "characteristics", "of", "EEG", "paroxysms", "and", "the", "relationship", "between", "EEG", "spikes", "and", "C0027066#ent", "<e1>", "patients", "with", "juvenile", "myoclonic", "epilepsy", "C0270853#ent", "<e2>", ")", "."], "h": {"id": "C0027066", "name": "C0027066#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0270853", "name": "C0270853#ent", "pos": [21, 22]}}
{"token": ["C0027066#ent", "<e1>", "serve", "as", "a", "reliable", "indicator", "of", "C0270853#ent", "<e2>", "and", "therefore", "should", "be", "screened", "for", "in", "any", "case", "of", "unprovoked", "generalized", "seizures"], "h": {"id": "C0027066", "name": "C0027066#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0270853", "name": "C0270853#ent", "pos": [8, 9]}}
{"token": ["Sheep", "plasma", "alpha", "1-protease", "inhibitor", "C1418544#ent", "<e1>", ")", "variants", "were", "typed", "by", "analysing", "C1417680#ent", "<e2>", "treated", "samples", "by", "isoelectric", "focusing", "in", "ultrathin", "polyacrylamide", "gels", "by", "staining", "for", "trypsin", "inhibition", "."], "h": {"id": "C1418544", "name": "C1418544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417680", "name": "C1417680#ent", "pos": [13, 14]}}
{"token": ["We", "have", "also", "identified", "several", "bovine", "cDNA", "clones", "related", "to", "C1415041#ent", "<e1>", "and", "show", "that", "at", "least", "one", "has", "an", "intact", "C1412821#ent", "<e2>", "two", "ITIM", "."], "h": {"id": "C1415041", "name": "C1415041#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [21, 22]}}
{"token": ["The", "C1418516#ent", "<e1>", "(PGM)-encoding", "gene", "of", "Bordetella", "bronchiseptica", "required", "for", "lipopolysaccharide", "(", "C2697656#ent", "<e2>", ")", "biosynthesis", "."], "h": {"id": "C1418516", "name": "C1418516#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [12, 13]}}
{"token": ["The", "present", "study", "injected", "C0360097#ent", "<e1>", "into", "nLM", "and", "then", "examined", "the", "effects", "of", "nLM", "blockade", "visual", "responses", "C0410422#ent", "<e2>", "neurons", "to", "target", "motion", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0410422", "name": "C0410422#ent", "pos": [18, 19]}}
{"token": ["Direct", "immunofluorescence", "performed", "on", "washed", "oral", "epithelial", "smears", "from", "thirteen", "patients", "with", "C0030809#ent", "<e1>", "thirteen", "patients", "with", "other", "C0012634#ent", "<e2>", "from", "ten", "subjects", "with", "clinically", "healthy", "oral", "mucosa"], "h": {"id": "C0030809", "name": "C0030809#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["A", "retrospective", "study", "the", "records", "of", "10", "patients", "with", "pemphigus", "erythematosus", "13", "patients", "with", "C0030809#ent", "<e1>", "set", "up", "to", "compare", "the", "courses", "of", "the", "two", "C0012634#ent", "<e2>", "."], "h": {"id": "C0030809", "name": "C0030809#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [25, 26]}}
{"token": ["C0220655#ent", "<e1>", "MPE", ")", "causes", "C0007177#ent", "<e2>", "an", "extremely", "poor", "outcome", "it", "is", "well", "controlled", "."], "h": {"id": "C0220655", "name": "C0220655#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007177", "name": "C0007177#ent", "pos": [5, 6]}}
{"token": ["The", "second", "developed", "a", "myelodysplastic", "syndrome", "a", "similar", "rash", "with", "histological", "features", "of", "C0036203#ent", "<e1>", "no", "systemic", "abnormalities", "from", "C0154254#ent", "<e2>", "cutaneous", "anergy", "multiple", "recall", "antigens", "and", "activation", "of", "circulating", "monocytes", "."], "h": {"id": "C0036203", "name": "C0036203#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0154254", "name": "C0154254#ent", "pos": [19, 20]}}
{"token": ["PYD", "and", "DPD", "levels", "were", "significantly", "correlated", "with", "all", "indices", "of", "bone", "turnover", "unlike", "C0733682#ent", "<e1>", ",", "which", "showed", "no", "correlation", "with", "bone", "formation", "markers", "AP", ",", "C2982447#ent", "<e2>", ",", "and", "BGP", ")", "."], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2982447", "name": "C2982447#ent", "pos": [27, 28]}}
{"token": ["Farnesylation", "is", "a", "posttranslational", "lipid", "modification", "which", "a", "15-carbon", "farnesyl", "isoprenoid", "is", "linked", "via", "a", "thioether", "bond", "specific", "cysteine", "residues", "of", "C0086376#ent", "<e1>", "in", "a", "reaction", "catalyzed", "by", "C0138837#ent", "<e2>", "FTase", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [28, 29]}}
{"token": ["C1420598#ent", "<e1>", "TBG", ")", "consists", "of", "a", "C1305923#ent", "<e2>", "4", "oligosaccharide", "units", "an", "average", "of", "10", "terminal", "sialic", "acid", "residues", "."], "h": {"id": "C1420598", "name": "C1420598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [7, 8]}}
{"token": ["We", "report", "a", "9-month-old", "male", "Latino", "infant", "C0162283#ent", "<e1>", "NDI", ")", "who", "presented", "with", "hypernatremic", "dehydration", "aggravated", "by", "severe", "C0017160#ent", "<e2>", "."], "h": {"id": "C0162283", "name": "C0162283#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017160", "name": "C0017160#ent", "pos": [19, 20]}}
{"token": ["Moreover", ",", "decrease", "of", "C2981746#ent", "<e1>", "following", "p53", "activation", "suggests", "a", "p53-dependent", "regulatory", "feedback", "of", "C1417089#ent", "<e2>", "function", "."], "h": {"id": "C2981746", "name": "C2981746#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417089", "name": "C1417089#ent", "pos": [15, 16]}}
{"token": ["Many", "of", "these", "disorders", "resemble", "C0012634#ent", "<e1>", "and", "the", "C1426113#ent", "<e2>", "signal", "with", "its", "regulators", "may", "provide", "rational", "molecular", "targets", "controlling", "certain", "C0012634#ent", "<e1>", "malignancy", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1426113", "name": "C1426113#ent", "pos": [9, 10]}}
{"token": ["C1826002#ent", "<e1>", ",", "another", "miRNA", "showing", "specific", "upregulation", "in", "C0033860#ent", "<e2>", ",", "is", "involved", "in", "the", "regulation", "of", "innate", "immune", "responses", "the", "tumour", "necrosis", "factor", "(TNF)-alpha", "pathway", "."], "h": {"id": "C1826002", "name": "C1826002#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [9, 10]}}
{"token": ["K18-null", "but", "not", "K8-null", "or", "heterozygous", "mice", "C1417581#ent", "<e1>", ",", "which", "indicates", "that", "C4284124#ent", "<e2>", "is", "important", "for", "MB", "formation", "."], "h": {"id": "C1417581", "name": "C1417581#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [13, 14]}}
{"token": ["In", "human", "livers", ",", "C1417581#ent", "<e1>", "showed", "colocalization", "of", "cytokeratin-8", "(", "C4284124#ent", "<e2>", ")", "with", "ubiquitin", "but", "not", "with", "beta-actin", "or", "ZO1", "."], "h": {"id": "C1417581", "name": "C1417581#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "the", "long-term", "treatment", "with", "C2982447#ent", "<e1>", "and", "1-NP", "can", "aggravate", "C1334103#ent", "<e2>"], "h": {"id": "C2982447", "name": "C2982447#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334103", "name": "C1334103#ent", "pos": [13, 14]}}
{"token": ["This", "would", "be", "compatible", "with", "an", "increased", "production", "of", "the", "reversible", ",", "endogenous", "monoamine", "oxidase", "inhibitor", "C0077020#ent", "<e1>", ",", "competing", "for", "the", "active", "site", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C0077020", "name": "C0077020#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [25, 26]}}
{"token": ["C0403379#ent", "<e1>", "an", "acute", "infectious", "process", "associated", "with", "C0011847#ent", "<e2>", "and", "obstruction", "."], "h": {"id": "C0403379", "name": "C0403379#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [8, 9]}}
{"token": ["Authors", "report", "on", "a", "case", "of", "C0403379#ent", "<e1>", "a", "woman", "affected", "with", "C0011847#ent", "<e2>", "and", "renal", "failure"], "h": {"id": "C0403379", "name": "C0403379#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [12, 13]}}
{"token": ["The", "highly", "conserved", "nature", "of", "this", "C0079429#ent", "<e1>", "suggests", "that", "the", "C0029007#ent", "<e2>", "identical", "functions", "in", "normal", "and", "neoplastic", "cells", "higher", "and", "lower", "vertebrates", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029007", "name": "C0029007#ent", "pos": [11, 12]}}
{"token": ["It", "was", "concluded", "that", "in", "many", "C0029896#ent", "<e1>", "there", "are", "conflicting", "reports", "on", "the", "usefulness", "of", "C0733383#ent", "<e2>", "and", "that", "there", "were", "few", "correlates", "of", "the", "therapeutic", "and", "immunological", "effects", "the", "drug", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0733383", "name": "C0733383#ent", "pos": [16, 17]}}
{"token": ["Three", "of", "four", "plasmids", "pAP2", ",", "C3537272#ent", "<e1>", ",", "and", "pAP4", "encode", "an", "C0014442#ent", "<e2>", "that", "confers", "ampicillin", "resistance", "host", "cells"], "h": {"id": "C3537272", "name": "C3537272#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["This", "study", "characterized", "the", "contributions", "of", "protein", "tyrosine", "kinase", "C0170168#ent", "<e1>", "nociceptin/orphanin", "FQ", "induced", "impairment", "of", "C0022614#ent", "<e2>", "cerebral", "hypoxia/ischemia", "anesthetized", "newborn", "pigs", "equipped", "with", "a", "closed", "cranial", "window", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [16, 17]}}
{"token": ["C0126120#ent", "<e1>", "is", "currently", "indicated", "only", "for", "the", "treatment", "of", "C0022573#ent", "<e2>", "although", "treatment", "efficacy", "has", "been", "demonstrated", "in", "patients", "with", "giant", "papillary", "conjunctivitis", "atopic", "keratoconjunctivitis"], "h": {"id": "C0126120", "name": "C0126120#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0022573", "name": "C0022573#ent", "pos": [10, 11]}}
{"token": ["We", "studied", "the", "efficacy", "of", "topically", "applied", "C0126120#ent", "<e1>", "%", "in", "the", "treatment", "of", "C0022573#ent", "<e2>"], "h": {"id": "C0126120", "name": "C0126120#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0022573", "name": "C0022573#ent", "pos": [14, 15]}}
{"token": ["The", "C0034861#ent", "<e1>", "with", "our", "specific", "monoclonal", "antibody", "with", "C1415975#ent", "<e2>", "from", "patients", "with", "atopic", "dermatitis"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [9, 10]}}
{"token": ["Other", "factors", "in", "addition", "to", "the", "structural", "differences", "of", "native", "and", "C0034861#ent", "<e1>", "also", "influence", "the", "C1415975#ent", "<e2>", "reactivities", "of", "tropomyosins", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [16, 17]}}
{"token": ["The", "purified", "CAE", "and", "C0034861#ent", "<e1>", "from", "CAE", "gene", "possessed", "common", "epitopes", "for", "C1415975#ent", "<e2>", "antibody", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [13, 14]}}
{"token": ["Using", "a", "substrate-cassette", "approach", ",", "P450", "activities", "were", "determined", "after", "incubation", "with", "the", "prototypic", "inhibitors", "tienilic", "acid", "C0608437#ent", "<e1>", ")", ",", "erythromycin", ",", "troleandomycin", ",", "and", "C0016365#ent", "<e2>", "(", "CYP3A4", ")", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [17, 18]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [26, 27]}}
{"token": ["These", "results", "suggest", "that", "CYP2D6", "and", "C0608437#ent", "<e1>", "polymorphisms", "contribute", "to", "the", "interindividual", "variability", "in", "C0016365#ent", "<e2>", "pharmacokinetics", "at", "steady-state", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [6, 7]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [15, 16]}}
{"token": ["This", "result", "suggests", "the", "implication", "of", "genetically", "polymorphic", "enzymes", ",", "presumably", "CYP2D6", ",", "C0608437#ent", "<e1>", "and", "CYP2C19", "in", "the", "metabolism", "of", "C0016365#ent", "<e2>", "to", "norfluoxetine", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [13, 14]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [21, 22]}}
{"token": ["N-Terminal", "sequencing", "latent", "and", "spontaneously", "activated", "C1721358#ent", "<e1>", "shows", "that", "it", "is", "a", "distinct", "C0162745#ent", "<e2>", "that", "is", "homologous", "to", "HFC", "and", "other", "members", "of", "the", "matrix", "metalloproteinase", "gene", "family"], "h": {"id": "C1721358", "name": "C1721358#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [14, 15]}}
{"token": ["C0079405#ent", "<e1>", "appeared", "to", "increase", "C1366571#ent", "<e2>", "expression", "and", "C1366571#ent", "<e2>", "promoter", "activity", "activating", "transcription", "factors", "NF-kappaB", "and", "NF-IL-6", "."], "h": {"id": "C0079405", "name": "C0079405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [5, 6]}}
{"token": ["A", "single-blind", "study", "the", "clinical", "efficacy", "biperiden", "hydrochloride", "C0591048#ent", "<e1>", ",", "Abbott", ")", "and", "C0041009#ent", "<e2>", "(", "Artane", ",", "Lederle", ")", "in", "the", "treatment", "of", "neuroleptic-induced", "Parkinsonism"], "h": {"id": "C0591048", "name": "C0591048#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041009", "name": "C0041009#ent", "pos": [14, 15]}}
{"token": ["Cases", "of", "dehydration", ",", "overweight", ",", "low", "physical", "fitness", "lack", "of", "acclimatization", ",", "C0009952#ent", "<e1>", "or", "infectious", "diseases", "and", "C0037274#ent", "<e2>", "be", "regarded", "a", "priori", "as", "predisposing", "factors", "heat", "intolerance"], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [19, 20]}}
{"token": ["Giant", "cell", "arteritis", "C0031036#ent", "<e1>", "systemic", "diseases", "rarely", "involve", "the", "C0024902#ent", "<e2>", "."], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024902", "name": "C0024902#ent", "pos": [10, 11]}}
{"token": ["There", "may", "be", "a", "role", "for", "C0032002#ent", "<e1>", "such", "as", "C1417740#ent", "<e2>", "in", "altered", "TSH", "gene", "expression", "fasting", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417740", "name": "C1417740#ent", "pos": [10, 11]}}
{"token": ["C0002962#ent", "<e1>", "relieved", "in", "two", "patients", "after", "C0073633#ent", "<e2>", "but", "pacing", "time", "to", "pain", "was", "unchanged", "in", "the", "remaining", "patients", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0073633", "name": "C0073633#ent", "pos": [7, 8]}}
{"token": ["We", "have", "recently", "identified", "the", "C1413861#ent", "<e1>", "the", "side-chain", "cleavage", "enzyme", "SCC", ")", "as", "the", "major", "adrenal", "autoantigens", "C0001403#ent", "<e2>", "the", "rare", "autoimmune", "polyendocrine", "syndrome", "type", "I", "APS-I", ")", ",", "respectively", "."], "h": {"id": "C1413861", "name": "C1413861#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [18, 19]}}
{"token": ["It", "leads", "to", "progressive", "dementia", ",", "C0233401#ent", "<e1>", "an", "incapacitating", "C0008489#ent", "<e2>", "culminating", "in", "premature", "death"], "h": {"id": "C0233401", "name": "C0233401#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008489", "name": "C0008489#ent", "pos": [10, 11]}}
{"token": ["The", "number", "of", "reported", "cases", "of", "C0039128#ent", "<e1>", ",", "including", "primary", ",", "secondary", "and", "C0039131#ent", "<e2>", "has", "been", "rapidly", "rising", "since", "1987", "."], "h": {"id": "C0039128", "name": "C0039128#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0039131", "name": "C0039131#ent", "pos": [14, 15]}}
{"token": ["C0031036#ent", "<e1>", "with", "typical", "cutaneous", "lesions", "of", "C0343190#ent", "<e2>", "visceral", "involvement", "at", "the", "time", "of", "diagnosis", "."], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0343190", "name": "C0343190#ent", "pos": [7, 8]}}
{"token": ["ChREBP", "is", "able", "to", "bind", "to", "the", "carbohydrate", "response", "element", "the", "promoter", "of", "C0034349#ent", "<e1>", "initiate", "the", "C0812327#ent", "<e2>"], "h": {"id": "C0034349", "name": "C0034349#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [17, 18]}}
{"token": ["Refeeding", "fasted", "rats", "a", "carbohydrate-rich", "diet", "stimulated", "an", "increase", "in", "C0034349#ent", "<e1>", "mRNA", ",", "preceded", "by", "an", "increase", "in", "the", "C0812327#ent", "<e2>"], "h": {"id": "C0034349", "name": "C0034349#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [20, 21]}}
{"token": ["Our", "data", "suggest", "that", "C0403447#ent", "<e1>", "patients", "with", "C1704876#ent", "<e2>", "does", "not", "significantly", "affect", "ventricular", "repolarization", "ventricular", "dispersion"], "h": {"id": "C0403447", "name": "C0403447#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704876", "name": "C1704876#ent", "pos": [8, 9]}}
{"token": ["Because", "these", "proteins", "participate", "in", "angiogenesis", ",", "glycolysis", ",", "C1418401#ent", "<e1>", "cancer", ",", "and", "ischemia", ",", "HIF-alpha", "and", "its", "C0127400#ent", "<e2>", "are", "attractive", "therapeutic", "targets", "."], "h": {"id": "C1418401", "name": "C1418401#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [19, 20]}}
{"token": ["C0042523#ent", "<e1>", "and", "methoxyverapamil", ",", "two", "C3539995#ent", "<e2>", "given", "intraperitoneally", ",", "were", "completely", "ineffective", "in", "preventing", "sound-induced", "seizures", "in", "DBA/2", "mice"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539995", "name": "C3539995#ent", "pos": [6, 7]}}
{"token": ["The", "apoLp-Ala", "inhibition", "is", "reversible", "by", "the", "addition", "of", "C0017860#ent", "<e1>", "before", "or", "after", "C0027203#ent", "<e2>", "additions", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}}
{"token": ["Addition", "of", "exogenous", "C0017860#ent", "<e1>", "to", "the", "ATPase", "assay", "produced", "an", "inhibition", "of", "the", "C0027203#ent", "<e2>", "similar", "in", "magnitude", "to", "that", "observed", "in", "tissue", "samples", "ischemic", "brain"], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}}
{"token": ["The", "irreversibility", "of", "the", "acyl", "bounds", "cleavage", "in", "C0017860#ent", "<e1>", ",", "a", "reversible", "monoglycerides", "isomerization", "an", "irreversible", "C0027203#ent", "<e2>", "deactivation", "have", "been", "assumed", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}}
{"token": ["On", "exit", "from", "metaphase", ",", "C1419392#ent", "<e1>", "is", "activated", "and", "binds", "to", "or", "modifies", "C0008546#ent", "<e2>", "."], "h": {"id": "C1419392", "name": "C1419392#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [14, 15]}}
{"token": ["The", "FOXO", "family", "of", "Forkhead", "transcription", "factors", "FKHR", "(", "FOXO1", ")", ",", "FKHR-L1", "(", "FOXO3a", ")", "and", "AFX", "(", "C1704966#ent", "<e1>", ")", ",", "are", "regulated", "by", "the", "C3813591#ent", "<e2>", "(", "PI3K-PKB/c-Akt", ")", "pathway", "."], "h": {"id": "C1704966", "name": "C1704966#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3813591", "name": "C3813591#ent", "pos": [27, 28]}}
{"token": ["Our", "data", "suggested", "that", "CSF", "cells", "pro-inflammatory", "cytokines", "through", "NF-kappaB", "activation", "C0025289#ent", "<e1>", ",", "and", "that", "increased", "NF-kappaB", "activation", "CSF", "cells", "C0729584#ent", "<e2>", "than", "carcinomatous", "meningitis"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0729584", "name": "C0729584#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "SB203580", "and", "C1456380#ent", "<e1>", "small", "interfering", "RNA", "enhanced", "C0812246#ent", "<e2>", "Thr-187", "phosphorylation", "as", "well", "as", "TAK1", "kinase", "activity", "indicating", "that", "the", "phosphorylation", "is", "affected", "by", "p38alpha/TAB1/TAB2-mediated", "feedback", "control", "of", "TAK1", "."], "h": {"id": "C1456380", "name": "C1456380#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [10, 11]}}
{"token": ["Using", "adenovirus-mediated", "gene", "transfer", "technique", "we", "further", "demonstrated", "that", "p38beta", ",", "but", "not", "C1456380#ent", "<e1>", ",", "is", "essential", "to", "protect", "the", "cells", "from", "C0812246#ent", "<e2>", "toxicity", "."], "h": {"id": "C1456380", "name": "C1456380#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [23, 24]}}
{"token": ["C1417932#ent", "<e1>", "C0029282#ent", "<e2>", ")", "activity", "was", "measured", "and", "C0029282#ent", "<e2>", "mRNA", "in", "the", "mucosa", "was", "determined", "by", "Northern", "blot", "analysis"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [2, 3]}}
{"token": ["Thus", ",", "how", "the", "C1420295#ent", "<e1>", "expression", "of", "C1705644#ent", "<e2>", "is", "regulated", "is", "important", "to", "our", "understanding", "of", "hematopoiesis", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705644", "name": "C1705644#ent", "pos": [8, 9]}}
{"token": ["HT1080", "clones", "expressing", "a", "modified", "DNA", "ligase", "III", "lacked", "a", "recognizable", "PEST", "domain", "significantly", "more", "resistant", "to", "killing", "by", "gamma-radiation", "or", "9-", "C0214192#ent", "<e1>", "were", "cells", "that", "C3889446#ent", "<e2>", "the", "wild-type", "form", "of", "DNA", "ligase", "III"], "h": {"id": "C0214192", "name": "C0214192#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [27, 28]}}
{"token": ["All", "patients", "received", "premedication", "with", "C0011777#ent", "<e1>", ",", "diphenhydramine", ",", "and", "C0008783#ent", "<e2>", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [11, 12]}}
{"token": ["Endoglin", "(", "C1704837#ent", "<e1>", ")", "is", "a", "C1415205#ent", "<e2>", "binds", "transforming", "growth", "factor", "and", "-beta3", ",", "and", "coprecipitates", "with", "the", "Ser/Thr", "kinase", "signaling", "receptor", "complex", "by", "affinity", "labeling", "endothelial", "and", "leukemic", "cells"], "h": {"id": "C1704837", "name": "C1704837#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415205", "name": "C1415205#ent", "pos": [7, 8]}}
{"token": ["C0771848#ent", "<e1>", "appeared", "to", "be", "more", "selective", "for", "central", "than", "peripheral", "C3541394#ent", "<e2>", "in", "rats", "."], "h": {"id": "C0771848", "name": "C0771848#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["C0771848#ent", "<e1>", "is", "metabolized", "via", "CYP-related", "C3541394#ent", "<e2>", ",", "especially", "CYP2D6", ",", "CYP3A4", ",", "and", "CYP1A2", "."], "h": {"id": "C0771848", "name": "C0771848#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [6, 7]}}
{"token": ["We", "found", "that", "the", "amplified", "gene", "of", "663", "bp", "nucleotides", "and", "was", "84", "%", "C1334043#ent", "<e1>", "with", "the", "human", "C1135159#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1135159", "name": "C1135159#ent", "pos": [19, 20]}}
{"token": ["Transgenic", "poplars", "Populus", "tremula", "Populus", "alba", "were", "obtained", "by", "introduction", "of", "a", "sense", "C1334043#ent", "<e1>", "transgene", "encoding", "caffeic", "acid", "O-methyltransferase", "C1135159#ent", "<e2>", ")", "under", "the", "control", "either", "of", "the", "cauliflower", "mosaic", "virus", "double", "35S", "promoter", "of", "the", "eucalyptus", "cinnamyl", "alcohol", "dehydrogenase", "promoter", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1135159", "name": "C1135159#ent", "pos": [20, 21]}}
{"token": ["Upon", "phosphorylation", ",", "the", "reconstituted", "C0014442#ent", "<e1>", "activities", "with", "C0005096#ent", "<e2>", "(", "N-demethylation", ")", "and", "7-ethoxycoumarin", "(", "O-deethylation", ")", "as", "substrates", "were", "reduced", "to", "30", "-", "40", "%", "of", "control", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005096", "name": "C0005096#ent", "pos": [9, 10]}}
{"token": ["In", "addition", "to", "the", "stereospecific", "15", "alpha-hydroxylation", "of", "progesterone", "(", "2.3", "min-1", ")", "and", "testosterone", "(", "2.5", "min-1", ")", ",", "the", "C0014442#ent", "<e1>", "catalyzed", "also", "7-ethoxycoumarin", "O-deethylation", "C0005096#ent", "<e2>", "aniline", "4-hydroxylation"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0005096", "name": "C0005096#ent", "pos": [27, 28]}}
{"token": ["This", "finding", "suggests", "that", "the", "neurological", "impairment", "frequent", "in", "C0025295#ent", "<e1>", "not", "a", "result", "of", "the", "activity", "of", "this", "C0027203#ent", "<e2>", "cortical", "glycolipids"], "h": {"id": "C0025295", "name": "C0025295#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [19, 20]}}
{"token": ["and", "C0066855#ent", "<e1>", "5,9-diethyl-2-(3-furylmethyl)2'-hydroxy-7,7-benzomorphan", ";", "1", "mg/kg", ")", "but", "not", "by", "C2343921#ent", "<e2>", "1", "mg/kg", ",", "s.c", ".", ")", ","], "h": {"id": "C0066855", "name": "C0066855#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2343921", "name": "C2343921#ent", "pos": [11, 12]}}
{"token": ["The", "structural", "model", "the", "basis", "for", "computationally", "C0012265#ent", "<e1>", "eight", "related", "C0007158#ent", "<e2>", "the", "putative", "binding", "site", "mAb", "1B3", "."], "h": {"id": "C0012265", "name": "C0012265#ent", "pos": [7, 8]}, "relation": "has_structural_class", "t": {"id": "C0007158", "name": "C0007158#ent", "pos": [11, 12]}}
{"token": ["The", "subsequent", "change", "to", "C0012265#ent", "<e1>", "had", "no", "further", "effect", "on", "mean", "C0007158#ent", "<e2>", "concentration", ",", "ventricular", "rate", "frequency", "of", "ventricular", "ectopic", "beats"], "h": {"id": "C0012265", "name": "C0012265#ent", "pos": [4, 5]}, "relation": "has_structural_class", "t": {"id": "C0007158", "name": "C0007158#ent", "pos": [12, 13]}}
{"token": ["The", "large", "form", "of", "C1412179#ent", "<e1>", "seen", "in", "monkey", "C0023899#ent", "<e2>", "and", "intermediary", "forms", "of", "the", "enzyme", "in", "chicken", "liver", "human", "erythrocytes", "."], "h": {"id": "C1412179", "name": "C1412179#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [9, 10]}}
{"token": ["Seven", "patients", "had", "electrocardiographic", "evidence", "C0155626#ent", "<e1>", "in", "addition", "to", "C1418571#ent", "<e2>", "and", "MB", "criteria", "."], "h": {"id": "C0155626", "name": "C0155626#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418571", "name": "C1418571#ent", "pos": [10, 11]}}
{"token": ["Three", "different", "nonsteroidal", "anti-inflammatory", "drugs", "NSAIDs", ")", "have", "been", "withdrawn", "in", "the", "UK", "and/or", "the", "US", "due", "to", "hepatotoxicity", "(", "C0054094#ent", "<e1>", ",", "ibufenac", ",", "and", "C0053111#ent", "<e2>", ")", "."], "h": {"id": "C0054094", "name": "C0054094#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0053111", "name": "C0053111#ent", "pos": [26, 27]}}
{"token": ["4", ")", "Such", "curing", "caused", "leakage", "of", "the", "C0013227#ent", "<e1>", "from", "the", "C0169014#ent", "<e2>", "liposomes", "in", "the", "very", "early", "stage", "no", "effect", "observed", "in", "the", "EPC/Cho", "liposomes", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0169014", "name": "C0169014#ent", "pos": [12, 13]}}
{"token": ["This", "Kruppel-like", "factor", "named", "mKlf7", ",", "binds", "specifically", "to", "an", "C1825588#ent", "<e1>", "core", "binding", "element", "that", "is", "crucial", "for", "in", "vivo", "C1704884#ent", "<e2>", "enhancer", "function", "."], "h": {"id": "C1825588", "name": "C1825588#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704884", "name": "C1704884#ent", "pos": [21, 22]}}
{"token": ["Neuromuscular", ",", "electrocardiographic", "and", "autonomic", "nervous", "were", "studied", "when", "C0013615#ent", "<e1>", "and", "four", "combinations", "of", "C0013615#ent", "<e1>", "and", "C0004259#ent", "<e1>", "were", "used", "to", "antagonise", "vecuronium-induced", "neuromuscular", "blockade", "87", "dogs", "anaesthetised", "with", "halothane", "."], "h": {"id": "C0013615", "name": "C0013615#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [18, 19]}}
{"token": ["The", "potencies", "against", "Gram-positive", "and", "other", "C0085423#ent", "<e1>", "comparable", "to", "benzalkonium", "chloride", "C0008196#ent", "<e2>", "."], "h": {"id": "C0085423", "name": "C0085423#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0008196", "name": "C0008196#ent", "pos": [12, 13]}}
{"token": ["Immune", "capture", "experiments", "demonstrated", "that", "p34", ",", "C1853155#ent", "<e1>", ",", "and", "NOPP44/46", "associate", "with", "C1421544#ent", "<e2>"], "h": {"id": "C1853155", "name": "C1853155#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421544", "name": "C1421544#ent", "pos": [14, 15]}}
{"token": ["These", "data", "support", "a", "notion", "that", "NK-104", "is", "a", "suitable", "C1254351#ent", "<e1>", "for", "the", "treatment", "of", "diabetic", "patients", "with", "C0020443#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [19, 20]}}
{"token": ["Results", "indicate", "that", "simvastatin", ",", "because", "of", "its", "activity", "and", "lack", "of", "toxicity", "and", "side", "effects", "can", "be", "considered", "a", "C1254351#ent", "<e1>", "of", "first-choice", "for", "the", "treatment", "of", "C0020443#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [28, 29]}}
{"token": ["The", "spectrum", "of", "diseases", "includes", "C0037199#ent", "<e1>", ",", "pneumonia", ",", "otitis", "media", "epiglotitis", ",", "and", "C0025297#ent", "<e2>", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [15, 16]}}
{"token": ["Streptococcus", "pneumoniae", "pneumococcus", ")", "is", "a", "leading", "cause", "of", "otitis", ",", "C0037199#ent", "<e1>", ",", "pneumonia", ",", "and", "C0025297#ent", "<e2>", "worldwide", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [17, 18]}}
{"token": ["BOP", "and", "HPOP", "target", "the", "kidneys", ",", "esophagus", "and", "upper", "respiratory", "system", "rats", ",", "but", "the", "C0771711#ent", "<e1>", "of", "this", "species", "is", "resistant", "to", "the", "above", "C0085169#ent", "<e2>", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085169", "name": "C0085169#ent", "pos": [26, 27]}}
{"token": ["The", "selected", "indigenous", "plants", "used", "in", "traditional", "herb", "remedies", "to", "treat", "C1290884#ent", "<e1>", "as", "asthma", ",", "bronchitis", ",", "C0009326#ent", "<e2>", ",", "and", "skin", "disorders", "to", "be", "mediated", "by", "leukotrienes", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [18, 19]}}
{"token": ["C0022336#ent", "<e1>", "also", "called", "\"", "prion", "diseases", ",", "are", "fatal", "C1456654#ent", "<e2>", "the", "central", "nervous", "system", "can", "occur", "in", "animals", "(", "such", "as", "the", "\"", "mad", "cow", "disease", "in", "cattle", ")", "and", "also", "in", "humans", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C1456654", "name": "C1456654#ent", "pos": [10, 11]}}
{"token": ["This", "was", "therefore", "a", "case", "of", "reactive", "(", "AA", ")", "C0002726#ent", "<e1>", "in", "the", "presence", "of", "C0023788#ent", "<e2>"], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023788", "name": "C0023788#ent", "pos": [16, 17]}}
{"token": ["Onset", "of", "sleep-related", "eating", "linked", "directly", "to", "the", "onset", "of", "SW", ",", "C1868117#ent", "<e1>", ",", "triazolam", "abuse", "nicotine", "abstinence", ",", "C0241910#ent", "<e2>", "narcolepsy", ",", "encephalitis", "or", "acute", "stress"], "h": {"id": "C1868117", "name": "C1868117#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0241910", "name": "C0241910#ent", "pos": [20, 21]}}
{"token": ["The", "objectives", "of", "this", "study", "was", "therefore", "to", "determine", "the", "prevalence", "of", "intestinal", "helminthic", "and", "C0033740#ent", "<e1>", "to", "determine", "the", "trends", "in", "intestinal", "C0747256#ent", "<e2>"], "h": {"id": "C0033740", "name": "C0033740#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [23, 24]}}
{"token": ["ureae", "has", "been", "isolated", "from", "cases", "of", "sinusitis", "and", "C0746102#ent", "<e1>", "is", "an", "extremely", "rare", "cause", "of", "C0025289#ent", "<e2>", "and", "septicaemia", "."], "h": {"id": "C0746102", "name": "C0746102#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [17, 18]}}
{"token": ["The", "Rep", "proteins", "been", "shown", "to", "repress", "the", "C1412056#ent", "<e1>", "p5", "promoter", "yet", "facilitate", "activation", "of", "the", "p19", "and", "C1826761#ent", "<e2>", "promoters", "during", "a", "productive", "infection"], "h": {"id": "C1412056", "name": "C1412056#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1826761", "name": "C1826761#ent", "pos": [19, 20]}}
{"token": ["Control", "of", "adeno-associated", "virus", "C1412056#ent", "<e1>", ")", "transcription", "from", "the", "three", "C1412056#ent", "<e1>", "promoters", "(", "p5", ",", "p19", ",", "and", "C1826761#ent", "<e1>", ")", "requires", "the", "adenovirus", "E1a", "protein", "the", "AAV", "nonstructural", "(", "Rep", ")", "proteins", "."], "h": {"id": "C1412056", "name": "C1412056#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826761", "name": "C1826761#ent", "pos": [20, 21]}}
{"token": ["C0033640#ent", "<e1>", "activated", "by", "dual", "phosphorylation", "Tyr", "and", "Thr", "(", "C0169101#ent", "<e2>", "can", "be", "grouped", "into", "two", "major", "classes", ":", "ERK", "and", "JNK", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [10, 11]}}
{"token": ["Similarly", ",", "ceramide", "activated", "the", "C0033640#ent", "<e1>", "JNK", "and", "C0169101#ent", "<e2>", "Jurkat", "cells", "not", "in", "JCaM1", "cells", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [9, 10]}}
{"token": ["A", "case", "is", "reported", "from", "Taiwan", "of", "a", "32-year-old", "woman", "suffering", "from", "C0039082#ent", "<e1>", "associated", "DM", "and", "C3831153#ent", "<e2>", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [17, 18]}}
{"token": ["C0042085#ent", "<e1>", "known", "as", "C0162569#ent", "<e2>", "HEP", ")", ",", "can", "involve", "several", "mutations", "."], "h": {"id": "C0042085", "name": "C0042085#ent", "pos": [0, 1]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0162569", "name": "C0162569#ent", "pos": [4, 5]}}
{"token": ["These", "results", "increase", "to", "39", "the", "number", "of", "mutations", "identified", "in", "the", "C0042085#ent", "<e1>", "4", "of", "them", "causing", "both", "C0162569#ent", "<e2>", "and", "f-PCT", "."], "h": {"id": "C0042085", "name": "C0042085#ent", "pos": [12, 13]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0162569", "name": "C0162569#ent", "pos": [19, 20]}}
{"token": ["Rapidly", "progressive", "C0017658#ent", "<e1>", "occurred", "in", "a", "woman", "with", "C0038013#ent", "<e2>", "RA", ")", "who", "had", "been", "treated", "with", "D-penicillamine", "for", "3", "months", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [9, 10]}}
{"token": ["The", "first", "patient", "developed", "subretinal", "fibrosis", "the", "right", "eye", "coupled", "with", "multifocal", "choroiditis", "serous", "retinal", "detachment", "both", "eyes", ",", "in", "the", "course", "of", "rapidly", "progressive", "C0017658#ent", "<e1>", "complicated", "with", "C0038013#ent", "<e2>"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [29, 30]}}
{"token": ["The", "results", "indicate", "that", "increased", "Ca(2+)", "influx", "into", "synaptosomes", "markedly", "activates", "C0243811#ent", "<e1>", "diphosphoinositide", "phosphodiesterase", "but", "has", "little", "or", "no", "effect", "C1377870#ent", "<e2>"], "h": {"id": "C0243811", "name": "C0243811#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1377870", "name": "C1377870#ent", "pos": [21, 22]}}
{"token": ["To", "investigate", "the", "effect", "of", "C0162508#ent", "<e1>", "Decoy", "on", "matrix", "metalloproteinase", "2", "MMP-2", ")", "and", "tissue", "inhibitor", "C1334706#ent", "<e2>", "(", "TIMP-1", ")", "imbalance", "induced", "by", "bleomycin-A5", "(", "BLM-A5", ")", "in", "pulmonary", "fibroblasts"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [17, 18]}}
{"token": ["A", "number", "of", "animal", "models", "been", "developed", "to", "study", "both", "the", "pathophysiology", "of", "C0018801#ent", "<e1>", "new", "therapeutic", "approaches", "this", "C0458219#ent", "<e2>"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0458219", "name": "C0458219#ent", "pos": [19, 20]}}
{"token": ["In", "conclusion", ",", "according", "to", "our", "data", "that", "NAIP", "deletion", "was", "more", "frequent", "in", "type", "I", "C4284041#ent", "<e1>", "than", "in", "C0152109#ent", "<e2>", "the", "NAIP", "gene", "be", "a", "modifying", "factor", "for", "disease", "severity", "C4284041#ent", "<e1>", "."], "h": {"id": "C4284041", "name": "C4284041#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0152109", "name": "C0152109#ent", "pos": [20, 21]}}
{"token": ["We", "conclude", "that", "in", "patients", "with", "bacterial", "and", "C0025297#ent", "<e1>", "and", "in", "a", "good", "clinical", "state", "the", "cerebral", "blood", "flow", "increased", "by", "C0020452#ent", "<e2>", ";", "with", "clinical", "deterioration", "cerebral", "haemodynamics", "worsen", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020452", "name": "C0020452#ent", "pos": [22, 23]}}
{"token": ["All", "leaky", "ptsH", "strains", "were", "fosfomycin", "sensitive", ",", "usually", "produced", "normal", "amounts", "of", "mutant", "HPr", "protein", "and", "had", "low", "but", "measurable", "activity", ",", "and", "C1337105#ent", "<e1>", "was", "detectable", "as", "a", "C0031686#ent", "<e2>", "."], "h": {"id": "C1337105", "name": "C1337105#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [30, 31]}}
{"token": ["Sixty", "patients", "exposed", "to", "methyl", "isocyanate", "presenting", "with", "C0037090#ent", "<e1>", "studied", "using", "bronchoalveolar", "lavage", "BAL", ")", "1", "-", "7", "C1337037#ent", "<e2>", "after", "the", "accident", "."], "h": {"id": "C0037090", "name": "C0037090#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1337037", "name": "C1337037#ent", "pos": [19, 20]}}
{"token": ["Solubilized", "in", "a", "soybean", "emulsion", ",", "propofol", "is", "one", "of", "a", "series", "of", "sterically", "hindered", "C0031428#ent", "<e1>", "that", "exhibit", "C0002932#ent", "<e2>"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002932", "name": "C0002932#ent", "pos": [19, 20]}}
{"token": ["ITCL", "has", "been", "successful", "in", "non-specific", "inflammations", "accompanying", "some", "virus", "dermatoses", "zoster", ",", "herpes", "simplex", ",", "in", "streptococcal", "pyoderma", "C0021099#ent", "<e1>", ",", "ecthyma", ")", ",", "and", "in", "some", "C0037274#ent", "<e2>", "disseminated", "eczema", "atopic", "dermatitis", "."], "h": {"id": "C0021099", "name": "C0021099#ent", "pos": [19, 20]}, "relation": "related_to", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [28, 29]}}
{"token": ["Twenty-two", "patients", "with", "C0041952#ent", "<e1>", "twenty-four-hour", "urinary", "excretion", "studies", "of", "C2936886#ent", "<e2>", ",", "phosphorus", ",", "and", "uric", "acid", "and", "after", "stone", "elimination", "from", "the", "urinary", "tract"], "h": {"id": "C0041952", "name": "C0041952#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [10, 11]}}
{"token": ["Fluoxetine", "and", "paroxetine", "are", "potent", "CYP2D6", "inhibitors", "whereas", "fluoxetine's", "metabolite", ",", "C0068987#ent", "<e1>", ",", "has", "a", "moderate", "inhibitory", "effect", "on", "C3714798#ent", "<e2>", "."], "h": {"id": "C0068987", "name": "C0068987#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [20, 21]}}
{"token": ["The", "extent", "of", "differential", "fibre", "type", "involvement", "in", "C0026850#ent", "<e1>", "be", "assessed", "quantitatively", "by", "the", "statistical", "parameters", "C0225326#ent", "<e2>", "nuclei", "content", "and", "nuclei", "distribution", "in", "the", "individual", "fibre", "types", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "C0040377#ent", "<e1>", "was", "compared", "to", "the", "effects", "of", "C0021246#ent", "<e2>", "and", "ibuprofen", "."], "h": {"id": "C0040377", "name": "C0040377#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [11, 12]}}
{"token": ["The", "anti-inflammatory", "activity", "the", "NSAID", "C0040377#ent", "<e1>", "been", "well", "described", ",", "being", "comparable", "in", "efficacy", "to", "C0021246#ent", "<e2>", "and", "effective", "for", "the", "relief", "of", "the", "acute", "and", "chronic", "symptoms", "accompany", "DJD", "."], "h": {"id": "C0040377", "name": "C0040377#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [16, 17]}}
{"token": ["C0040377#ent", "<e1>", "and", "ibuprofen", "resemble", "C0021246#ent", "<e2>", "in", "reducing", "renal", "blood", "flow", "in", "shifting", "the", "distribution", "of", "renal", "cortical", "flow", "from", "the", "inner", "cortex", "the", "outer", "cortex"], "h": {"id": "C0040377", "name": "C0040377#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [5, 6]}}
{"token": ["We", "show", "here", "that", "the", "Mos1", "synaptic", "complex", "of", "the", "two", "inverted", "terminal", "repeats", "of", "the", "element", "brought", "together", "by", "a", "C0076934#ent", "<e1>", "is", "designated", "paired-end", "complex", "2", "(", "C1419241#ent", "<e2>", ")", "."], "h": {"id": "C0076934", "name": "C0076934#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1419241", "name": "C1419241#ent", "pos": [29, 30]}}
{"token": ["To", "assess", "the", "efficacy", "of", "functional", "electrical", "stimulation", "(", "C0812383#ent", "<e1>", ")", "in", "the", "rehabilitation", "of", "C0018989#ent", "<e2>", "in", "stroke", "."], "h": {"id": "C0812383", "name": "C0812383#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [16, 17]}}
{"token": ["Over", "these", "years", "she", "developed", "several", "C0004364#ent", "<e1>", "including", "Sj\u00f6gren's", "syndrome", "Hashimoto's", "thyroiditis", "premature", "ovarian", "failure", "compatible", "with", "C1535942#ent", "<e2>", ",", "amegakaryocytic", "thrombocytopenic", "purpura", "and", "finally", "pure", "red", "cell", "aplasia"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1535942", "name": "C1535942#ent", "pos": [18, 19]}}
{"token": ["Most", "of", "these", "diseases", "cause", ",", "C0009952#ent", "<e1>", ",", "influenza", "like", "illness", ",", "headache", ",", "C0024031#ent", "<e2>", ",", "abdominal", "pain", "and", "fatigue", "."], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "C0028094#ent", "<e1>", "prevents", "the", "decrease", "in", "CBF", "induced", "by", "C0036077#ent", "<e2>", ",", "but", "that", "C0028094#ent", "<e1>", "does", "not", "prevent", "the", "deterioration", "in", "the", "CAP", "."], "h": {"id": "C0028094", "name": "C0028094#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "we", "found", "that", "C1414260#ent", "<e1>", "stimulates", "a", "Gbetagamma-mediated", ",", "PKA-dependent", "phosphorylation", "and", "inactivation", "of", "C0244989#ent", "<e2>", "GSK3", ")", ",", "an", "enzyme", "that", "regulates", "cell", "growth"], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0244989", "name": "C0244989#ent", "pos": [16, 17]}}
{"token": ["Assays", "of", "the", "aryl", "hydrocarbon", "hydroxylase", "C0919425#ent", "<e1>", ")", "activity", "in", "the", "C1419029#ent", "<e2>", "preparation", "revealed", "decreased", "C0919425#ent", "<e1>", "activity", "with", "increase", "in", "Se", "concentration", "."], "h": {"id": "C1419029", "name": "C1419029#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [6, 7]}}
{"token": ["The", "C1419029#ent", "<e1>", "fraction", "from", "rabbits", "also", "shows", "a", "low", "aryl", "hydrocarbon", "hydroxylase", "C0919425#ent", "<e2>", ")", "activity", "."], "h": {"id": "C1419029", "name": "C1419029#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [13, 14]}}
{"token": ["Ser64", "phosphorylation", "was", "induced", "by", "activated", "Ras", "and", "Raf", "but", "was", "not", "blocked", "by", "C0003015#ent", "<e1>", "MEK1/2", ",", "phosphatidylinositol", "3-kinase", "JNK", ",", "or", "C1456378#ent", "<e2>"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [23, 24]}}
{"token": ["The", "sclerosant", "(", "5", "percent", "C0037530#ent", "<e1>", "was", "injected", "into", "all", "visible", "C0042345#ent", "<e2>", "near", "the", "gastroesophageal", "junction", "a", "MacBeth", "needle", "."], "h": {"id": "C0037530", "name": "C0037530#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [12, 13]}}
{"token": ["We", "gradually", "discontinued", "C1367551#ent", "<e1>", ",", "and", "the", "patient's", "serum", "C2936886#ent", "<e2>", "remained", "normal", "during", "the", "following", "11", "months", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [10, 11]}}
{"token": ["Salmon", "C1367551#ent", "<e1>", "strongly", "suppressed", "the", "C2936886#ent", "<e2>", "release", "from", "mouse", "calvaria", "in", "the", "presence", "of", "membrane", "IL-1", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [6, 7]}}
{"token": ["Perifused", "islets", "isolated", "from", "C1263960#ent", "<e1>", "Px", "rats", "showed", "reduced", "insulin", "responses", "C1999257#ent", "<e2>", "and", "GIP", "."], "h": {"id": "C1263960", "name": "C1263960#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1999257", "name": "C1999257#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "a", "3xNFAT-luc", "C0206414#ent", "<e1>", "that", "NFAT3", "transcriptional", "activity", "increased", "in", "a", "dose-dependent", "manner", "by", "C1367731#ent", "<e2>", "or", "JNK2", "."], "h": {"id": "C0206414", "name": "C0206414#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [16, 17]}}
{"token": ["Forty-seven", "patients", "receiving", "non-cisplatin-containing", "chemotherapy", "were", "entered", "in", "a", "prospective", "study", "which", "the", "efficacy", "of", "ondansetron", "plus", "C0011777#ent", "<e1>", "and", "tropisetron", "plus", "C0011777#ent", "<e1>", "in", "the", "prophylaxis", "of", "C0042963#ent", "<e1>", "evaluated", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0042963", "name": "C0042963#ent", "pos": [28, 29]}}
{"token": ["The", "first", "technique", "involved", "the", "human", "C1367578#ent", "<e1>", "the", "second", "the", "transcript", "analysis", "the", "iduronate-2-sulfatase", ",", "C1705964#ent", "<e2>", ",", "and", "glucose-6-phospate", "dehydrogenase", "genes"], "h": {"id": "C1367578", "name": "C1367578#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705964", "name": "C1705964#ent", "pos": [16, 17]}}
{"token": ["Thus", "the", "enhanced", "resistance", "to", "cell", "death", "by", "phosphorylation", "defective", "mutant", "C0376515#ent", "<e1>", "might", "be", "attributed", "to", "its", "inability", "to", "associate", "with", "C1418582#ent", "<e2>", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418582", "name": "C1418582#ent", "pos": [22, 23]}}
{"token": ["We", "describe", "the", "case", "of", "a", "53-year-old", "man", "who", "had", "undergone", "stem", "cell", "autograft", "multiple", "myeloma", "developed", "visceral", "VZV", "infection", "with", "C0019158#ent", "<e1>", ",", "melaena", "and", "C0919671#ent", "<e2>", "7", "months", "later", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0919671", "name": "C0919671#ent", "pos": [26, 27]}}
{"token": ["Isolated", "purified", "C1456795#ent", "<e1>", "also", "bound", "to", "C0008546#ent", "<e2>", "to", "H1-stripped", "chromatin", "and", "to", "native", "DNA", "in", "solution", "at", "physiological", "ionic", "strength"], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [7, 8]}}
{"token": ["Poor", "results", "were", "attributable", "to", "the", "postoperative", "rebleeding", "from", "the", "untreated", "C0751001#ent", "<e1>", "which", "were", "thought", "to", "be", "C0741160#ent", "<e2>", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0751001", "name": "C0751001#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0741160", "name": "C0741160#ent", "pos": [18, 19]}}
{"token": ["In", "a", "rat", "model", "of", "stroke", ",", "post-insult", "treatment", "with", "lithium", "or", "C0080356#ent", "<e1>", ",", "another", "mood", "stabilizer", "at", "therapeutic", "doses", "reduces", "C0751955#ent", "<e2>", "neurological", "deficits"], "h": {"id": "C0080356", "name": "C0080356#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0751955", "name": "C0751955#ent", "pos": [22, 23]}}
{"token": ["Phosphorylation", "of", "Ser(876", ")", "of", "C2751306#ent", "<e1>", "correlated", "with", "the", "activation", "status", "the", "C0031727#ent", "<e2>", "."], "h": {"id": "C2751306", "name": "C2751306#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["In", "vivo", "specific", "antagonism", "of", "either", "PDGF-B", "or", "TGF-beta", "in", "experimental", "C0235618#ent", "<e1>", "in", "an", "almost", "complete", "inhibition", "of", "C1334506#ent", "<e2>", "accumulation", ",", "which", "suggests", "an", "interaction", "between", "signaling", "pathways", "these", "two", "growth", "factors"], "h": {"id": "C0235618", "name": "C0235618#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334506", "name": "C1334506#ent", "pos": [19, 20]}}
{"token": ["To", "ascertain", "the", "mechanism", "for", "rebound", "acid", "hypersecretion", "treatment", "with", "an", "H2-receptor", "blocker", ",", "we", "investigated", "the", "effects", "of", "C0034665#ent", "<e1>", "on", "gastric", "H+,K(+)-adenosine", "triphosphatase", "(", "C1706373#ent", "<e2>", ")", "in", "rats", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [26, 27]}}
{"token": ["This", "disease", "is", "an", "C0030328#ent", "<e1>", "unknown", "etiology", ",", "fever", ",", "C0159028#ent", "<e2>", "typical", "subcutaneous", "nodes"], "h": {"id": "C0030328", "name": "C0030328#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0159028", "name": "C0159028#ent", "pos": [11, 12]}}
{"token": ["The", "CSX/NKX2", "-", "5", "C0017337#ent", "<e1>", "is", "thus", "a", "good", "candidate", "for", "various", "C0018799#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [13, 14]}}
{"token": ["In", "this", "pilot", "study", "we", "tested", "whether", "C4255227#ent", "<e1>", "when", "it", "is", "fused", "with", "C1421227#ent", "<e2>", ",", "can", "resist", "Vif-mediated", "proteasomal", "degradation", "further", "inhibit", "HIV-1", "infection"], "h": {"id": "C4255227", "name": "C4255227#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421227", "name": "C1421227#ent", "pos": [14, 15]}}
{"token": ["The", "newest", "class", "of", "antiemetics", "used", "for", "the", "prevention", "and", "treatment", "of", "PONV", "are", "the", "C0036753#ent", "<e1>", "ondansetron", ",", "granisetron", ",", "C0063322#ent", "<e2>", ",", "dolasetron", ")", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0063322", "name": "C0063322#ent", "pos": [21, 22]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "the", "effect", "of", "the", "C0036753#ent", "<e1>", "granisetron", ",", "ondansetron", "and", "C0063322#ent", "<e2>", "on", "cholera", "toxin-induced", "hypersecretion", "in", "the", "pig", "jejunum", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0063322", "name": "C0063322#ent", "pos": [18, 19]}}
{"token": ["While", "she", "died", "of", "peritoneal", "recurrence", "the", "surgery", ",", "the", "case", "suggested", "the", "C1121259#ent", "<e1>", "controlling", "the", "advanced", "cancer-bearing", "state", "by", "combination", "chemotherapy", "C2828372#ent", "<e2>", ",", "instead", "of", "surgery", "."], "h": {"id": "C1121259", "name": "C1121259#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2828372", "name": "C2828372#ent", "pos": [23, 24]}}
{"token": ["The", "emerging", "clinical", "importance", "of", "C0038160#ent", "<e1>", "us", "to", "establish", "a", "reference", "database", "C0035681#ent", "<e2>", "rpoB", ";", "nucleotides", "1444", "-", "1928", ")", "gene", "sequences", "type", "strains", "of", "all", "staphylococcal", "species", "subspecies", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [13, 14]}}
{"token": ["Lithium", "in", "vitro", "inhibited", "adenylate", "cyclase", "stimulated", "by", "C0022245#ent", "<e1>", ",", "GTP", "or", "C0248868#ent", "<e2>", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0248868", "name": "C0248868#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "have", "identified", "a", "C1431910#ent", "<e1>", "termed", "CARDIAK", "(", "for", "CARD-containing", "interleukin", "(IL)-1", "beta", "converting", "enzyme", "ICE", ")", "associated", "C0031727#ent", "<e2>", ")", ",", "which", "contains", "a", "serine/threonine", "kinase", "domain", "a", "carboxy-terminal", "CARD"], "h": {"id": "C1431910", "name": "C1431910#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["The", "analysis", "of", "pharmaceutical", "actives", "described", ",", "including", "beta", "blocker", "C0087093#ent", "<e1>", ")", ",", "antidepressant", "(", "paroxetine", ")", ",", "analgesic", "(", "C0000970#ent", "<e2>", ")", "and", "opiate", "(", "codeine", ")", "preparations", "."], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [21, 22]}}
{"token": ["C1413930#ent", "<e1>", ",", "biglycan", ",", "syndecan-1", "and", "C0167183#ent", "<e2>", "showed", "gene", "expressions", "with", "OASIS", "."], "h": {"id": "C1413930", "name": "C1413930#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0167183", "name": "C0167183#ent", "pos": [7, 8]}}
{"token": ["The", "overlap", "between", "scleroderma", "and", "C0008312#ent", "<e1>", "antimitochondrial", "antibodies", "M2", "is", "also", "known", "as", "C0748397#ent", "<e2>"], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0748397", "name": "C0748397#ent", "pos": [14, 15]}}
{"token": ["C0164786#ent", "<e1>", "is", "an", "excellent", "substrate", "for", "catalytic", "subunit", "C0010531#ent", "<e2>", "Km", "=", "4", "microM", ",", "Vmax", "=", "18.6", "mumol/min/mg", ")", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [9, 10]}}
{"token": ["Carbohydrate", "composition", "changes", "of", "glycoconjugates", "constituting", "the", "glycocalix", "of", "C0206064#ent", "<e1>", "be", "involved", "in", "the", "alterations", "of", "cell-cell", "interactions", "in", "C0011884#ent", "<e2>"], "h": {"id": "C0206064", "name": "C0206064#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [20, 21]}}
{"token": ["This", "paper", "discusses", "these", "new", "criteria", "for", "C0149931#ent", "<e1>", "and", "other", "C0018681#ent", "<e2>"], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [11, 12]}}
{"token": ["Similar", "medications", "are", "effective", "in", "C0149931#ent", "<e1>", "and", "muscle", "contraction", "headache", "the", "term", "recurrent", "C0018681#ent", "<e2>", "is", "used", "to", "cover", "the", "spectrum", "of", "classic", "C0149931#ent", "<e1>", "and", "muscle", "contraction", "headache"], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "TSH", "were", "mimicked", "by", "C0917964#ent", "<e1>", "and", "those", "of", "TPA", "by", "a", "synthetic", "diacylglycerol", "C1515696#ent", "<e2>", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1515696", "name": "C1515696#ent", "pos": [17, 18]}}
{"token": ["In", "a", "double-blind", "study", "patients", "with", "a", "total", "of", "129", "episodes", "of", "recurrent", "C0019342#ent", "<e1>", "treated", "topically", "with", "0.3", "%", "C0070895#ent", "<e2>", "or", "placebo", "cream", "."], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0070895", "name": "C0070895#ent", "pos": [20, 21]}}
{"token": ["After", "the", "RMP", "test", "the", "hippocampal", "neuronal", "density", "following", "C0917798#ent", "<e1>", "observed", "histologically", "and", "the", "effect", "of", "C0106291#ent", "<e2>", "on", "it", "examined", "."], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0106291", "name": "C0106291#ent", "pos": [17, 18]}}
{"token": ["Eighteen", "children", "with", "C0004096#ent", "<e1>", "administered", "equal", "doses", "of", "C0001927#ent", "<e2>", "either", "through", "a", "nebulizer", "and", "face", "mask", "a", "dose-metered", "inhaler", "spacer", "(", "Volumatic", ")", "and", "tidal", "breathing", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [9, 10]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "assess", "the", "diaphragmatic", "excursion", "the", "TM-mode", "ultrasonography", "concomitant", "pneumotachography", "in", "eight", "normal", "and", "five", "C0004096#ent", "<e1>", "subjects", "before", "and", "after", "C0001927#ent", "<e2>", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}, "relation": "may_be_treated_by", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [27, 28]}}
{"token": ["To", "describe", "inflammatory", "cervical", "spine", "disorders", "C3714757#ent", "<e1>", "JCA", ")", "patients", "with", "C0003864#ent", "<e2>", "AM", ")", "hand", "deformity"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [12, 13]}}
{"token": ["The", "available", "C1516468#ent", "<e1>", "the", "treatment", "of", "herpes", "simplex", "type", "1", "2", "and", "C0586989#ent", "<e2>", "discussed", "in", "respect", "of", "their", "mechanism", "of", "action", ",", "clinical", "effects", "and", "side", "effects"], "h": {"id": "C1516468", "name": "C1516468#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0586989", "name": "C0586989#ent", "pos": [13, 14]}}
{"token": ["The", "long-term", "efficacy", "and", "safety", "of", "Elmiron", "(", "oral", "C0524684#ent", "<e1>", "in", "relieving", "recurring", "symptoms", "of", "C0282488#ent", "<e2>", "IC", ")", "were", "investigated", "in", "a", "long-term", ",", "open-label", "physician", "'s", "usage", "study", "."], "h": {"id": "C0524684", "name": "C0524684#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0282488", "name": "C0282488#ent", "pos": [16, 17]}}
{"token": ["C0524684#ent", "<e1>", "PPS", ")", "was", "compared", "with", "placebo", "for", "the", "symptomatic", "therapy", "C0282488#ent", "<e2>", "a", "double-blind", ",", "multicenter", "study"], "h": {"id": "C0524684", "name": "C0524684#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0282488", "name": "C0282488#ent", "pos": [12, 13]}}
{"token": ["Light-induced", "virucidal", "activity", "of", "C0063220#ent", "<e1>", "was", "demonstrated", "against", "equine", "infectious", "anemia", "virus", "a", "lentivirus", "structurally", ",", "C1516876#ent", "<e2>", ",", "and", "antigenically", "related", "to", "the", "human", "immunodeficiency", "virus"], "h": {"id": "C0063220", "name": "C0063220#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [17, 18]}}
{"token": ["This", "is", "a", "property", "shared", "with", "bucindolol", ",", "another", "beta-blocker", "and", "C3537240#ent", "<e1>", "that", "is", "structurally", "similar", "to", "C1815010#ent", "<e2>", "."], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1815010", "name": "C1815010#ent", "pos": [18, 19]}}
{"token": ["Most", "of", "these", "hybrid", "drugs", "beta-adrenoceptor", "blockers", "an", "additional", "C3537240#ent", "<e1>", "component", ",", "such", "as", "labetalol", ",", "dilevalol", ",", "C1815010#ent", "<e2>", "and", "celiprolol", "."], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1815010", "name": "C1815010#ent", "pos": [19, 20]}}
{"token": ["Clones", "overexpressing", "FAT", "protein", "a", "modified", "ability", "of", "induction", "of", "C1418401#ent", "<e1>", "low", "concentration", "threshold", "of", "anti-IgM", "antibodies", ",", "suggesting", "that", "C0059239#ent", "<e2>", "may", "play", "a", "role", "in", "modulating", "IgM-induced", "apoptotic", "signaling"], "h": {"id": "C1418401", "name": "C1418401#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [21, 22]}}
{"token": ["C1425030#ent", "<e1>", "is", "a", "unique", "C0017337#ent", "<e2>", "without", "homologs", "in", "sequence", "databases", "."], "h": {"id": "C1425030", "name": "C1425030#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}}
{"token": ["Charcot-Marie-Tooth", "[", "CMT", "]", "C1848862#ent", "<e1>", "is", "the", "most", "common", "C0392553#ent", "<e2>"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0392553", "name": "C0392553#ent", "pos": [10, 11]}}
{"token": ["C1166521#ent", "<e1>", "when", "co-administered", "with", "C0294000#ent", "<e2>", "restored", "blood", "ALAD", "activity", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0294000", "name": "C0294000#ent", "pos": [5, 6]}}
{"token": ["Co-administration", "of", "C1166521#ent", "<e1>", "in", "combination", "with", "monoisoamyl", "dimercaptosuccinic", "acid", "(", "C0294000#ent", "<e2>", ")", "against", "chronic", "arsenic", "poisoning", "mice", "was", "studied", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0294000", "name": "C0294000#ent", "pos": [11, 12]}}
{"token": ["TBF", ",", "BTF", "and", "C1333690#ent", "<e1>", "exerted", "more", "potent", "fungicidal", "action", "NCZ", "and", "C0022625#ent", "<e2>", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [13, 14]}}
{"token": ["The", "mechanisms", "are", "often", "different", "between", "the", "heterogeneous", "models", "acquired", "and", "C0020538#ent", "<e1>", "but", "Gi", "protein", "and", "C1367657#ent", "<e2>", "downregulation", "have", "been", "observed", "frequently", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [17, 18]}}
{"token": ["The", "question", "as", "to", "why", "there", "is", "an", "evidently", "raised", "C0020676#ent", "<e1>", "the", "subsequent", "months", "of", "life", "in", "C2697643#ent", "<e2>", "cases", "is", "discussed", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2697643", "name": "C2697643#ent", "pos": [18, 19]}}
{"token": ["C0035661#ent", "<e1>", "was", "more", "potent", "than", "C0282213#ent", "<e2>", "in", "increasing", "the", "circulating", "levels", "of", "cyclic", "AMP"], "h": {"id": "C0035661", "name": "C0035661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282213", "name": "C0282213#ent", "pos": [6, 7]}}
{"token": ["Six", "out", "of", "21", "infants", "to", "C0035661#ent", "<e1>", "and", "six", "out", "of", "nine", "infants", "exposed", "to", "C0282213#ent", "<e2>", "showed", "a", "degree", "of", "ECG", "ischaemia", "persisted", "for", "several", "weeks", "."], "h": {"id": "C0035661", "name": "C0035661#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0282213", "name": "C0282213#ent", "pos": [16, 17]}}
{"token": ["We", "previously", "reported", "that", "murine", "C2675212#ent", "<e1>", "was", "regulated", "by", "NF-kappaB", ",", "octamer", "binding", "proteins", "and", "C1335193#ent", "<e2>", "(", "B", "cell-specific", "activator", "protein", "."], "h": {"id": "C2675212", "name": "C2675212#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335193", "name": "C1335193#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "with", "C0029408#ent", "<e1>", "of", "the", "knee", ",", "C0538927#ent", "<e2>", "100", "and", "200", "mg", "and", "naproxen", "500", "mg", "twice", "daily", "were", "similarly", "efficacious", "and", "superior", "to", "placebo", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [9, 10]}}
{"token": ["The", "Saccharomyces", "cerevisiae", "C0079941#ent", "<e1>", "encodes", "a", "predicted", "protein", "displaying", "similarity", "in", "organization", "to", "C1419150#ent", "<e2>", ",", "a", "scaffolding", "protein", "organizes", "signaling", "and", "actin", "cytoskeletal", "regulating", "activities", "in", "many", "higher", "eucaryotic", "cell", "types", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419150", "name": "C1419150#ent", "pos": [14, 15]}}
{"token": ["Fifty", "patients", "suffering", "from", "acute", "soft", "tissue", "rheumatism", "an", "open", "parallel", "group", "study", "C0016377#ent", "<e1>", "200", "mg", "to", "400", "mg", "daily", "versus", "C0031990#ent", "<e2>", "20", "mg", "to", "40", "mg", "daily", "for", "4", "weeks", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [22, 23]}}
{"token": ["Two", "complementary", "C0011522#ent", "<e1>", "for", "the", "organic", "anion", "transporter", "subtypes", "C1420131#ent", "<e2>", "and", "oatp3", ",", "which", "transport", "thyroid", "hormones", "well", "as", "taurocholate", ",", "were", "isolated", "from", "a", "rat", "retina", "cDNA", "library"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420131", "name": "C1420131#ent", "pos": [10, 11]}}
{"token": ["Comparing", "to", "C0039663#ent", "<e1>", ",", "the", "patients", "with", "C1705297#ent", "<e2>", "in", "our", "study", "had", "milder", "liver", "demage", "and", "lower", "ALT", "levels", ",", "and", "most", "of", "them", "(", "10/16", ")", "were", "symptomless", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [8, 9]}}
{"token": ["Inactivation", "of", "a", "Wnt", "signaling", "pathway", "by", "the", "C1414886#ent", "<e1>", "transforms", "the", "C2609259#ent", "<e2>", "sheath", "cell", "its", "sister", ",", "the", "C2609259#ent", "<e2>", "neuron", "."], "h": {"id": "C1414886", "name": "C1414886#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2609259", "name": "C2609259#ent", "pos": [12, 13]}}
{"token": ["The", "data", "suggest", "a", "role", "for", "C1334899#ent", "<e1>", "variation", "in", "the", "underlying", "cause", "of", "C1956346#ent", "<e2>", "."], "h": {"id": "C1334899", "name": "C1334899#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["It", "was", "concluded", "that", "WMD", "of", "lambs", "in", "Hokkaido", "was", "C0026850#ent", "<e1>", "from", "deficiencies", "of", "Toc", "and", "C1414863#ent", "<e2>", "to", "their", "ewes", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [17, 18]}}
{"token": ["In", "fission", "yeast", "the", "replication", "checkpoint", "enforced", "by", "the", "C0296594#ent", "<e1>", "human", "Chk2", ")", ",", "which", "regulates", "both", "cell", "cycle", "progression", "C1333237#ent", "<e2>", "ensure", "that", "the", "genome", "is", "faithfully", "duplicated", "prior", "to", "mitosis", "."], "h": {"id": "C0296594", "name": "C0296594#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [21, 22]}}
{"token": ["C0296594#ent", "<e1>", "activated", "by", "DNA", "damage", "regulate", "cell", "cycle", "arrest", "C1333237#ent", "<e2>", "and", "apoptosis", "."], "h": {"id": "C0296594", "name": "C0296594#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [10, 11]}}
{"token": ["Two", "syndromes", "affecting", "cognitive", "and", "motor", "function", "the", "setting", "of", "AIDS", "have", "been", "described", "as", "C0085584#ent", "<e1>", "HIVE", ")", "and", "progressive", "C0023524#ent", "<e2>", "PML", ")", "."], "h": {"id": "C0085584", "name": "C0085584#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [21, 22]}}
{"token": ["The", "roles", "of", "C4082284#ent", "<e1>", "p38", "MAPK", "TPA-induced", "activation", "of", "C2986464#ent", "<e2>", "in", "mouse", "skin", "been", "defined", "in", "our", "previous", "studies", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [10, 11]}}
{"token": ["The", "potencies", "to", "cause", "disorganization", "of", "actin", "filaments", "consistent", "with", "potencies", "of", "these", "C0035064#ent", "<e1>", "as", "inhibitors", "of", "C1377871#ent", "<e2>", "and", "enhancers", "of", "tight", "junction", "permeability", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1377871", "name": "C1377871#ent", "pos": [18, 19]}}
{"token": ["The", "114", "specimens", "from", "syphilis", "cases", "comprised", "40", "from", "cases", "of", "primary", "syphilis", "43", "from", "cases", "of", "secondary", "syphilis", "19", "from", "cases", "of", "early", "C1260915#ent", "<e1>", "and", "12", "from", "cases", "of", "C0039133#ent", "<e2>"], "h": {"id": "C1260915", "name": "C1260915#ent", "pos": [24, 25]}, "relation": "has_nichd_parent", "t": {"id": "C0039133", "name": "C0039133#ent", "pos": [31, 32]}}
{"token": ["The", "data", "from", "this", "randomised", "phase", "II", "study", "that", "C1416418#ent", "<e1>", "provides", "a", "better", "response", "rate", "C1420388#ent", "<e2>", ",", "and", "that", "C1416418#ent", "<e1>", "should", "be", "investigated", "further", "for", "the", "treatment", "of", "metastatic", "gastric", "cancer"], "h": {"id": "C1420388", "name": "C1420388#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416418", "name": "C1416418#ent", "pos": [9, 10]}}
{"token": ["Overexpression", "of", "C0162508#ent", "<e1>", "(", "jun", "and", "fos", "proteins", "also", "inhibited", "androgen-induced", "C1426033#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426033", "name": "C1426033#ent", "pos": [12, 13]}}
{"token": ["Overexpression", "of", "AP-1", "(", "C0162508#ent", "<e1>", "and", "fos", "proteins", "also", "inhibited", "androgen-induced", "C1426033#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1426033", "name": "C1426033#ent", "pos": [12, 13]}}
{"token": ["Shortly", "thereafter", ",", "they", "became", "C1416536#ent", "<e1>", "and", "had", "excessive", "fatigue", ",", "C0018681#ent", "<e2>", "sleep", "disturbances", "irritability", ",", "unstable", "moods", "and", "hypertension", "."], "h": {"id": "C1416536", "name": "C1416536#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [12, 13]}}
{"token": ["In", "the", "present", "study", ",", "three", "extremely", "minor", "but", "novel", "Chol-1", "antigens", ",", "termed", "X1", ",", "X2", ",", "and", "C1421546#ent", "<e1>", "have", "been", "isolated", "from", "bovine", "brain", "C0017083#ent", "<e2>", "."], "h": {"id": "C1421546", "name": "C1421546#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017083", "name": "C0017083#ent", "pos": [27, 28]}}
{"token": ["C2733158#ent", "<e1>", "are", "rare", "complications", "during", "treatments", "with", "C0000598#ent", "<e2>", "."], "h": {"id": "C2733158", "name": "C2733158#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000598", "name": "C0000598#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "the", "secretion", "of", "TNF-alpha", "and", "C1522428#ent", "<e1>", "be", "differentially", "regulated", "by", "TSST-1", "and", "that", "C0033640#ent", "<e2>", "an", "important", "role", "in", "mediating", "cytokine", "responses", "the", "toxin", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [18, 19]}}
{"token": ["RNA", "was", "isolated", "and", "analysed", "using", "bovine", "cDNA", "and", "ovine", "genomic", "probe", "for", "C1421313#ent", "<e1>", "UCP", ")", ",", "cDNA", "for", "subunits", "III", "IV", "of", "C1537985#ent", "<e2>", "cDNA", "for", "ADP/ATP", "carrier"], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [24, 25]}}
{"token": ["Multivariate", "analysis", "that", "the", "TT", "genotype", "C0919427#ent", "<e1>", "and", "the", "apoE4", "C1706112#ent", "<e2>", "are", "independent", "risk", "factors", "CHD", "in", "the", "Japanese", "."], "h": {"id": "C0919427", "name": "C0919427#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [11, 12]}}
{"token": ["The", "collapse", "of", "delta", "pH", "caused", "by", "C0039683#ent", "<e1>", "required", "SecA", ",", "C1705556#ent", "<e2>", ",", "and", "SecY", "and", "was", "not", "detected", "when", "normal", "membrane", "vesicles", "used", "."], "h": {"id": "C0039683", "name": "C0039683#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [12, 13]}}
{"token": ["We", "determined", "the", "copy", "number", "this", "locus", "in", "355", "patients", "with", "C0010674#ent", "<e1>", "CF", ")", ",", "and", "tested", "for", "correlation", "between", "C1333213#ent", "<e2>", "genomic", "copy", "number", "lung", "disease", "associated", "with", "CF", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C1333213", "name": "C1333213#ent", "pos": [21, 22]}}
{"token": ["We", "conclude", "that", "C0014130#ent", "<e1>", "affecting", "sympathetic", "activity", "like", "pheochromocytoma", "or", "C3831153#ent", "<e2>", "influence", "the", "circadian", "blood", "pressure", "rhythm", "whereas", "the", "renin-aldosterone-system", "has", "no", "major", "impact", "on", "the", "diurnal", "blood", "pressure", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [11, 12]}}
{"token": ["Because", "C0014130#ent", "<e1>", "common", "(", "e.g.", ",", "diabetes", "mellitus", "hyperparathyroidism", ",", "and", "C3831153#ent", "<e2>", ")", ",", "they", "should", "be", "considered", "in", "the", "differential", "diagnosis", "management", "of", "osteopenia", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [12, 13]}}
{"token": ["Ischemia", "promotes", "deacetylation", "of", "core", "histone", "proteins", "H3", "and", "C1415443#ent", "<e1>", "and", "dimethylation", "of", "C3829685#ent", "<e2>", "H3-K9", ")", "over", "the", "MOR-1", "promoter", ",", "an", "signature", "of", "epigenetic", "gene", "silencing"], "h": {"id": "C1415443", "name": "C1415443#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3829685", "name": "C3829685#ent", "pos": [14, 15]}}
{"token": ["The", "removal", "of", "MDP", "C0026821#ent", "<e1>", "is", "an", "effective", "prophylactic", "measure", "elimination", "of", "C0020538#ent", "<e2>"], "h": {"id": "C0026821", "name": "C0026821#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [13, 14]}}
{"token": ["Unlike", "wild-type", "C1336608#ent", "<e1>", "or", "PSF", ",", "which", "are", "nuclear", "proteins", "C1854588#ent", "<e2>", "is", "not", "a", "nuclear", "protein", "is", "targeted", "to", "the", "endosomal", "compartment"], "h": {"id": "C1336608", "name": "C1336608#ent", "pos": [2, 3]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1854588", "name": "C1854588#ent", "pos": [11, 12]}}
{"token": ["Muscle", "strips", "from", "equine", "trachea", "were", "preincubated", "for", "60", "min", "with", "10(-7)M", "C1161352#ent", "<e1>", ",", "10(-6)M", "neostigmine", ",", "and", "10(-5", ")", "M", "C0018318#ent", "<e2>", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018318", "name": "C0018318#ent", "pos": [22, 23]}}
{"token": ["The", "energy-conserving", "corrinoid-containing", "MtrA-H", "complex", "from", "Methanobacterium", "thermoautotrophicum", "composed", "of", "eight", "different", "C0599220#ent", "<e1>", "of", "which", "C1417453#ent", "<e2>", "harbors", "the", "corrinoid", "prosthetic", "group", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417453", "name": "C1417453#ent", "pos": [16, 17]}}
{"token": ["C0291140#ent", "<e1>", ",", "the", "recombinantly", "produced", "C0014442#ent", "<e2>", ",", "is", "gradually", "replacing", "the", "human", "placental", "derived", "alglucerase", "in", "the", "treatment", "of", "gaucher", "patients", "."], "h": {"id": "C0291140", "name": "C0291140#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}}
{"token": ["Through", "binding", "to", "the", "C1418218#ent", "<e1>", "exogenously", "applied", "Ap2A", ",", "P18", ",", "and", "C1413246#ent", "<e2>", "increased", "the", "intracellular", "cAMP", "concentration", "and", "stimulated", "platelet", "production", "nitric", "oxide", "the", "most", "important", "endogenous", "antiaggregant", "."], "h": {"id": "C1418218", "name": "C1418218#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413246", "name": "C1413246#ent", "pos": [13, 14]}}
{"token": ["On", "the", "other", "hand", ",", "the", "C0360714#ent", "<e1>", "simvastatin", "reduced", "both", "cholesterol", "and", "C0597790#ent", "<e2>", "[14C]acetate", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0597790", "name": "C0597790#ent", "pos": [13, 14]}}
{"token": ["MDC9", "(", "ADAM9/meltrin", "gamma", ")", "is", "a", "widely", "expressed", "and", "catalytically", "active", "metalloprotease-disintegrin", "protein", "that", "has", "been", "implicated", "in", "the", "ectodomain", "cleavage", "C1704816#ent", "<e1>", "HB-EGF", ")", "and", "as", "an", "C0171484#ent", "<e2>", "the", "amyloid", "precursor", "protein"], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0171484", "name": "C0171484#ent", "pos": [29, 30]}}
{"token": ["A", "three-year-old", "boy", ",", "who", "was", "previously", "healthy", ",", "had", "a", "severe", "attack", "of", "C0025007#ent", "<e1>", "which", "resulted", "in", "C0010043#ent", "<e2>", "blindness", "and", "axillary", "nerve", "palsy", "the", "same", "side", "with", "subglenoid", "subluxation", "the", "humerus", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010043", "name": "C0010043#ent", "pos": [19, 20]}}
{"token": ["A", "series", "of", "promoter-GUS", "fusion", "constructs", "containing", "a", "portion", "of", "the", "C3887669#ent", "<e1>", "tpi", ")", "promoter", ",", "the", "first", "C1420871#ent", "<e2>", "and", "the", "gene", "encoding", "bacterial", "beta-glucuronidase", "GUS", ")", "were", "made", "."], "h": {"id": "C3887669", "name": "C3887669#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420871", "name": "C1420871#ent", "pos": [19, 20]}}
{"token": ["Using", "antibody", "against", "NADPH-cytochrome", "P-450", "reductase", "several", "effectors", "of", "cytochrome", "P-450", "C3888280#ent", "<e1>", "we", "investigated", "nicotine", "metabolites", "formed", "by", "these", "two", "C3540017#ent", "<e2>", "."], "h": {"id": "C3888280", "name": "C3888280#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [21, 22]}}
{"token": ["The", "authors", "present", "six", "cases", "of", "rheumatoid", "arthritis", "RA", ")", "complicated", "by", "vasculitis", "of", "varying", "clinical", "presentation", "2", "cases", "of", "C0005122#ent", "<e1>", ",", "5", "cases", "of", "C0037284#ent", "<e2>", "dry", "gangrene", "ulcers", ",", "purpura", ")", "."], "h": {"id": "C0005122", "name": "C0005122#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [26, 27]}}
{"token": ["The", "most", "common", "manifestation", "of", "infection", "due", "to", "C0026919#ent", "<e1>", "NTM", ")", "in", "children", "is", "C0024205#ent", "<e2>", "an", "otherwise", "healthy", "patient", "."], "h": {"id": "C0026919", "name": "C0026919#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024205", "name": "C0024205#ent", "pos": [15, 16]}}
{"token": ["Specimens", "of", "the", "primary", "carcinoma", "available", "for", "analysis", "of", "hormone", "receptor", "Ki67", "labelling", "index", ",", "C1414313#ent", "<e1>", "EGFR", ")", ",", "c-erbB-2", ",", "p53", "and", "ras", "C3470429#ent", "<e2>", "."], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [25, 26]}}
{"token": ["A", "new", "gamma-aminobutyric", "acid", "derivative", "N-phthaloyl", "GABA", "C0083693#ent", "<e1>", ")", ",", "was", "synthesised", "and", "its", "C0003286#ent", "<e2>", "tested", "and", "compared", "with", "sodium", "valproate", "efficacy", "against", "experimentally", "induced", "convulsions", "in", "mice", "."], "h": {"id": "C0083693", "name": "C0083693#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [15, 16]}}
{"token": ["The", "binding", "of", "125I-r-Fim", "to", "C1705662#ent", "<e1>", "beads", "coated", "with", "C1424869#ent", "<e2>", "PRP1", ")", "or", "statherin", "was", "four", "and", "two", "times", "greater", ",", "respectively", ",", "than", "that", "to", "uncoated", "C1705662#ent", "<e1>", "beads", "."], "h": {"id": "C1705662", "name": "C1705662#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424869", "name": "C1424869#ent", "pos": [10, 11]}}
{"token": ["The", "beneficial", "effect", "of", "cyclosporin", "A", "in", "asthma", "may", "be", "related", "to", "its", "inhibitory", "effect", "on", "the", "C0004096#ent", "<e1>", "induction", "of", "T-cell", "apoptosis", "decreased", "C4042483#ent", "<e2>", "levels", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4042483", "name": "C4042483#ent", "pos": [24, 25]}}
{"token": ["Moreover", ",", "24-hour", ",", "waking", "and", "sleeping", "ambulatory", "C2740858#ent", "<e1>", "were", "significantly", "reduced", "by", "C0042523#ent", "<e2>", "."], "h": {"id": "C2740858", "name": "C2740858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [14, 15]}}
{"token": ["C0282488#ent", "<e1>", "IC", ")", "is", "a", "C0005686#ent", "<e2>", "which", "the", "etiology", "is", "unknown", "."], "h": {"id": "C0282488", "name": "C0282488#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0005686", "name": "C0005686#ent", "pos": [6, 7]}}
{"token": ["C0282488#ent", "<e1>", "IC", ")", "is", "a", "C0005686#ent", "<e2>", "with", "symptoms", "including", "pelvic", "and", "or", "perineal", "pain", "urinary", "frequency", "and", "urgency", "."], "h": {"id": "C0282488", "name": "C0282488#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0005686", "name": "C0005686#ent", "pos": [6, 7]}}
{"token": ["An", "increased", "number", "of", "activated", "mast", "cells", "been", "documented", "in", "C0282488#ent", "<e1>", "IC", ")", ",", "a", "C0005686#ent", "<e2>", "primarily", "in", "women", "and", "exacerbated", "by", "stress", "."], "h": {"id": "C0282488", "name": "C0282488#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0005686", "name": "C0005686#ent", "pos": [16, 17]}}
{"token": ["New", "C0040615#ent", "<e1>", ",", "such", "as", "amisulpride", ",", "clozapine", ",", "olanzapine", ",", "C0073393#ent", "<e2>", ",", "quetiapine", ",", "ziprasidone", ",", "zotepine", "and", "aripiprazole", ",", "may", "interact", "with", "both", "dopamine", "and", "serotonin", "receptors"], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [12, 13]}}
{"token": ["The", "typical", "C0040615#ent", "<e1>", "atypical", "antipsychotics", "olanzapine", ",", "quetiapine", "and", "C0073393#ent", "<e2>", "were", "administered", "to", "pregnant", "Sprague-Dawley", "dams", "the", "drinking", "water", "Days", "8", "to", "18", "of", "gestation", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [10, 11]}}
{"token": ["Atypical", "C0040615#ent", "<e1>", "(", "quetiapine", ",", "olanzapine", ",", "C0073393#ent", "<e2>", "and", "clozapine", ")", "are", "increasingly", "prescribed", "in", "Australia", ",", "and", "emergency", "departments", "growing", "rates", "of", "overdose", "of", "these", "agents", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [8, 9]}}
{"token": ["Except", "for", "reserpine", ",", "catalepsy", "scores", "significantly", "lower", "in", "C1705931#ent", "<e1>", "C1416746#ent", "<e2>", "mice", "than", "in", "C1705931#ent", "<e1>", "WT", "mice", "low", "doses", "these", "cataleptogenic", "agents", "."], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705931", "name": "C1705931#ent", "pos": [9, 10]}}
{"token": ["The", "unique", "downregulation", "effect", "of", "C1705931#ent", "<e1>", "C1416746#ent", "<e2>", "was", "confirmed", "by", "comparing", "C1705931#ent", "<e1>", "KO-SCH", "with", "WT-SCH", "gene", "groups", "."], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705931", "name": "C1705931#ent", "pos": [5, 6]}}
{"token": ["We", "previously", "reported", "that", "deletion", "of", "BTN1", "(", "btn1-delta", ")", ",", "an", "ortholog", "of", "the", "human", "Batten", "disease", "C0751383#ent", "<e1>", ",", "resulted", "in", "a", "decrease", "in", "vacuolar", "pH", "during", "C1414316#ent", "<e2>"], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414316", "name": "C1414316#ent", "pos": [29, 30]}}
{"token": ["Our", "results", "demonstrate", "putative", "roles", "of", "C1335283#ent", "<e1>", "and", "SHP-2", "in", "the", "progression", "of", "both", "C0009663#ent", "<e2>", "cervical", "cancer", "HPV", "infection", "."], "h": {"id": "C1335283", "name": "C1335283#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009663", "name": "C0009663#ent", "pos": [15, 16]}}
{"token": ["Mice", "given", "C0030883#ent", "<e1>", "after", "receiving", "C0010592#ent", "<e2>", ",", "60", "mg/kg", ",", "slept", "a", "statistically", "significant", "times", "longer", "than", "did", "controls", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [6, 7]}}
{"token": ["C0010414#ent", "<e1>", "was", "the", "initial", "manifestation", "of", "the", "C0039082#ent", "<e2>", "in", "7", "patients", ",", "and", "the", "initial", "opportunistic", "infection", "an", "additional", "7", "."], "h": {"id": "C0010414", "name": "C0010414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}}
{"token": ["C0010414#ent", "<e1>", "in", "patients", "with", "the", "C0039082#ent", "<e2>", "is", "a", "debilitating", "disease", "that", "does", "not", "respond", "to", "conventional", "therapy", "earlier", "diagnosis", "or", "long-term", "suppressive", "therapy", "improve", "the", "prognosis", "."], "h": {"id": "C0010414", "name": "C0010414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}}
{"token": ["It", "appears", "that", "aphidicolin", "and", "ara-C", "both", "affect", "a", "common", "target", "on", "the", "C0012892#ent", "<e1>", "which", "is", "different", "from", "that", "affected", "by", "C0286411#ent", "<e2>", "in", "vivo.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0286411", "name": "C0286411#ent", "pos": [22, 23]}}
{"token": ["A", "clinical", "study", "C0006938#ent", "<e1>", "performed", "in", "10", "patients", "with", "C0018801#ent", "<e2>", "20", "with", "severe", "heart", "failure"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [10, 11]}}
{"token": ["C0006938#ent", "<e1>", "was", "evaluated", "as", "an", "adjuvant", "to", "diuretic", "and", "digoxin", "therapy", "C0018801#ent", "<e2>", "old", "age", "using", "walking", "ability", "minute", "ventilation", "oxygen", "consumption", "plasma", "atrial", "natriuretic", "factor", "ANF", ")", "concentration", "as", "measures", "of", "outcome", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}}
{"token": ["As", "demonstrated", "by", "HPLC", ",", "C0268731#ent", "<e1>", "converted", "C20:4", "predominantly", "to", "C0023837#ent", "<e2>", "12-HETE-", "and", ",", "to", "a", "lesser", "extent", ",", "to", "PG", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [11, 12]}}
{"token": ["In", "order", "to", "rule", "out", "the", "synthesis", "of", "hydroxylated", "fatty", "acids", "platelets", "and", "leukocytes", "entrapped", "in", "the", "C0268731#ent", "<e1>", ",", "we", "studied", "C0023837#ent", "<e2>", "glomerular", "epithelial", "cells", "9", "days", "in", "cell", "culture"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [22, 23]}}
{"token": ["The", "presence", "of", "one", "or", "several", "processing", "C3540772#ent", "<e1>", "in", "the", "wheat", "germ", "cell-free", "system", "indicated", "by", "the", "effect", "of", "C0146951#ent", "<e2>"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [20, 21]}}
{"token": ["To", "test", "this", "hypothesis", ",", "in", "two", "separate", "protocols", "10", "%", "C0733854#ent", "<e1>", "was", "infused", "into", "a", "dorsal", "hand", "vein", "heparin", "to", "activate", "C1416902#ent", "<e2>", "raise", "fatty", "acid", "levels", "locally", "."], "h": {"id": "C0733854", "name": "C0733854#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [23, 24]}}
{"token": ["The", "hydrolysis", "in", "vitro", "preactivated", "C0733854#ent", "<e1>", "(", "an", "artificial", "triacylglycerol-phospholipid", "emulsion", ")", "by", "rat", "adipose", "tissue", "C1416902#ent", "<e2>", "inhibited", "by", "rat", "high-density", "lipoprotein", "HDL", ")", "."], "h": {"id": "C0733854", "name": "C0733854#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [17, 18]}}
{"token": ["C0733854#ent", "<e1>", "is", "a", "suitable", "substrate", "for", "measuring", "C1416902#ent", "<e2>", "activity", "in", "the", "presence", "of", "other", "triacylglycerol", "lipases", "heart", "and", "myocytes", "."], "h": {"id": "C0733854", "name": "C0733854#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [8, 9]}}
{"token": ["Corresponding", "to", "the", "increased", "activity", "of", "C4083833#ent", "<e1>", "GLDH", ")", "in", "serum", "in", "C0005398#ent", "<e2>", "swelling", "of", "hepatic", "mitochondria", "be", "shown", "on", "ultrastructural", "morphometric", "analysis"], "h": {"id": "C4083833", "name": "C4083833#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005398", "name": "C0005398#ent", "pos": [13, 14]}}
{"token": ["Other", "C0029896#ent", "<e1>", "that", "may", "have", "a", "herpesvirus", "component", "or", "trigger", "susceptible", "C0003451#ent", "<e2>", "atherosclerosis", "and", "multiple", "sclerosis"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [12, 13]}}
{"token": ["Lastly", ",", "BNP", "stimulated", "the", "C4082284#ent", "<e1>", "cyclic", "guanosine", "monophosphate-dependent", "protein", "kinase", "signaling", "and", "two", "C1513344#ent", "<e2>", "U0126", "and", "PD98059", ",", "reversed", "BNP", "inhibition", "of", "TGF-beta-induced", "collagen-1", "expression", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1513344", "name": "C1513344#ent", "pos": [15, 16]}}
{"token": ["PDGF-BB-induced", "Egr-1", "activation", "was", "suppressed", "by", "inhibitors", "of", "2", "upstream", "activators", "Egr-1", ",", "C4082284#ent", "<e1>", "ERK", ")", "and", "Src", "family", "kinases", "whereas", "antioxidants", ",", "phosphatidylinositol", "3-phosphate", "kinase", "and", "C1513344#ent", "<e2>", "no", "effect"], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1513344", "name": "C1513344#ent", "pos": [28, 29]}}
{"token": ["Alternative", "splicing", "along", "with", "the", "multiplicity", "of", "genes", "in", "the", "molecular", "family", "includes", "C1416695#ent", "<e1>", ",", "produce", "diversity", "among", "the", "C-terminal", "ends", "of", "C1416692#ent", "<e2>", "."], "h": {"id": "C1416695", "name": "C1416695#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416692", "name": "C1416692#ent", "pos": [23, 24]}}
{"token": ["The", "most", "important", "development", "in", "elucidating", "the", "pathogenesis", "of", "C0021051#ent", "<e1>", "achieved", "in", "C0398689#ent", "<e2>"], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0398689", "name": "C0398689#ent", "pos": [13, 14]}}
{"token": ["Severe", "neurological", "symptoms", "including", "C1720189#ent", "<e1>", "hallucinations", "and", "C0036572#ent", "<e2>", ",", "associated", "with", "metabolic", "acidosis", "branched-chain", "amino-acidemia", "in", "a", "six-year-old", "girl", "with", "a", "variant", "form", "of", "maple", "syrup", "urine", "disease"], "h": {"id": "C1720189", "name": "C1720189#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}}
{"token": ["C0002986#ent", "<e1>", "AFD", ")", "is", "a", "rare", "X-linked", "disorder", "by", "C0085078#ent", "<e2>", "several", "glycosphingolipids", ",", "affecting", "virtually", "all", "organs", "and", "systems", "."], "h": {"id": "C0002986", "name": "C0002986#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [10, 11]}}
{"token": ["In", "mice", "bearing", "either", "tumor", "model", "administration", "of", "C0072994#ent", "<e1>", "significantly", "decreased", "serum", "growth", "hormone", "insulin-like", "growth", "factor", "I", "C1334089#ent", "<e2>", ")", "levels", "."], "h": {"id": "C0072994", "name": "C0072994#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "C0072994#ent", "<e1>", "(", "50", "microg/day", ")", "reduced", "serum", "C1334089#ent", "<e2>", "by", "19", "%", "(", "p", "<", "0.05", ")", ",", "but", "did", "not", "significantly", "decrease", "tumor", "weight"], "h": {"id": "C0072994", "name": "C0072994#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [11, 12]}}
{"token": ["The", "amyloid", "beta", "peptide", "A", "beta", ")", "of", "C2931257#ent", "<e1>", "derived", "from", "the", "proteolytic", "processing", "the", "amyloid", "precursor", "proteins", "C1705770#ent", "<e2>", ")", ",", "which", "are", "considered", "type", "I", "transmembrane", "proteins"], "h": {"id": "C2931257", "name": "C2931257#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705770", "name": "C1705770#ent", "pos": [19, 20]}}
{"token": ["Test", "compounds", "the", "fungicide", ",", "C0078245#ent", "<e1>", "and", "the", "clinical", "antiandrogen", "C0056855#ent", "<e2>"], "h": {"id": "C0078245", "name": "C0078245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0056855", "name": "C0056855#ent", "pos": [11, 12]}}
{"token": ["Papillomas", "and", "squamous", "cell", "carcinomas", "mechanically", "dispersed", "immediately", "after", "resection", "and", "were", "placed", "in", "a", "modified", "Hanks", "'", "solution", "with", "C0962754#ent", "<e1>", ",", "trypsin", ",", "hyaluronidase", ",", "bovine", "albumin", "and", "C0813866#ent", "<e2>", "."], "h": {"id": "C0962754", "name": "C0962754#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0813866", "name": "C0813866#ent", "pos": [30, 31]}}
{"token": ["Consistent", "with", ",", "whole", "cell", "lysates", "GM-CSF-treated", "C1860224#ent", "<e1>", "demonstrated", "increased", "C0031667#ent", "<e2>", "PLA2", ")", "activity", "."], "h": {"id": "C1860224", "name": "C1860224#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [11, 12]}}
{"token": ["Incubation", "of", "the", "C1333200#ent", "<e1>", "human", "neutrophils", "with", "the", "proteolytically", "activated", "form", "of", "C1259877#ent", "<e2>", "in", "the", "phosphorylation", "of", "several", "components", ",", "including", "a", "20-kDa", "polypeptide", ",", "probably", "consisting", "of", "myosin", "light", "chains"], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}}
{"token": ["Calpain-catalysed", "hydrolysis", "of", "platelet", "substrates", "as", "C1333200#ent", "<e1>", "and", "calmodulin-binding", "proteins", "and", "of", "C1259877#ent", "<e2>", "is", "assumed", "to", "contribute", "to", "platelet", "aggregation"], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}}
{"token": ["C0016788#ent", "<e1>", "is", "an", "extremely", "rare", ",", "autosomal", "C0017361#ent", "<e2>", "lysosomal", "storage", "disease", "characterized", "by", "a", "deficiency", "of", "the", "lysosomal", "hydrolase", "alpha", "fucosidase"], "h": {"id": "C0016788", "name": "C0016788#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [8, 9]}}
{"token": ["Of", "these", "microRNAs", ",", "C2825936#ent", "<e1>", "restoration", "reduces", "overall", "tumour", "growth", "proliferation", ",", "whereas", "C2826030#ent", "<e2>", "inhibits", "metastatic", "cell", "invasion"], "h": {"id": "C2825936", "name": "C2825936#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2826030", "name": "C2826030#ent", "pos": [14, 15]}}
{"token": ["C0011777#ent", "<e1>", "and", "MK-886", "both", "inhibited", "the", "cytokine-induced", "mPGES-1", "expression", "while", "C3538682#ent", "<e2>", "and", "cPGES", "expression", "remained", "unaffected", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538682", "name": "C3538682#ent", "pos": [11, 12]}}
{"token": ["The", "biochemical", "function", "the", "C3541394#ent", "<e1>", "encoded", "on", "the", "10-kb", "C0017258#ent", "<e2>", "the", "flavin", "monooxygenase", "the", "lactone", "hydrolase", "the", "alcohol", "dehydrogenase", "and", "the", "aldehyde", "dehydrogenase", "was", "determined", "in", "Escherichia", "coli", "on", "the", "ability", "to", "convert", "cyclododecanone", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017258", "name": "C0017258#ent", "pos": [10, 11]}}
{"token": ["C0003417#ent", "<e1>", "such", "as", "trimeprazine", "and", "C0013085#ent", "<e2>", ",", "and", "some", "nonsteroidal", "anti-inflammatory", "agents", "such", "as", "indomethacin", ",", "also", "should", "be", "avoided", "during", "pregnancy", "and", "lactation", "."], "h": {"id": "C0003417", "name": "C0003417#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013085", "name": "C0013085#ent", "pos": [6, 7]}}
{"token": ["Combined", "treatment", "with", "benzo(a)pyrene", "(", "classic", "inductor", "of", "C3899480#ent", "<e1>", "CYPA1", "and", "CYP1A2", ")", "and", "alpha-tocopherol", "decreased", "benzo(a)pyrene-induced", "C0059735#ent", "<e2>", "rat", "liver", "."], "h": {"id": "C3899480", "name": "C3899480#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [18, 19]}}
{"token": ["We", "now", "describe", "a", "third", "C1854664#ent", "<e1>", "phenotype", "(LCCS3)--similar", "to", "LCCS2", "yet", "without", "C0005697#ent", "<e2>"], "h": {"id": "C1854664", "name": "C1854664#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [13, 14]}}
{"token": ["In", "C0033806#ent", "<e1>", ",", "as", "distinguished", "from", "what", "Drezner", "et", "al.", "called", "C2932717#ent", "<e2>", "the", "response", "of", "cyclic", "AMP", "uniformly", "low", ",", "while", "that", "of", "phosphate", "was", "variable", "."], "h": {"id": "C0033806", "name": "C0033806#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C2932717", "name": "C2932717#ent", "pos": [12, 13]}}
{"token": ["HslVU", "is", "a", "bacterial", "homolog", "the", "proteasome", ",", "where", "HslV", "is", "the", "C1947941#ent", "<e1>", "that", "is", "activated", "by", "HslU", ",", "an", "C1706373#ent", "<e2>", "and", "chaperone", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [21, 22]}}
{"token": ["To", "clarify", "the", "conformational", "changes", "associated", "with", "ATP", "binding", "and", "hydrolysis", ",", "we", "used", "C1947941#ent", "<e1>", "sensitivity", "to", "monitor", "the", "conformations", "of", "the", "PAN", "C1706373#ent", "<e2>", "from", "Methanococcus", "jannischii", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [24, 25]}}
{"token": ["Additional", "litters", "were", "exposed", "to", "same", "oxygen", "treatments", "supplemented", "twice", "daily", "with", "either", "C3274912#ent", "<e1>", "saline", "or", "liposomes", "containing", "saline", "without", "C1704945#ent", "<e2>", "."], "h": {"id": "C3274912", "name": "C3274912#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [21, 22]}}
{"token": ["Total", "hip", "arthroplasty", "C1564278#ent", "<e1>", ")", "is", "generally", "proposed", "for", "renal", "transplant", "patients", "with", "invalidating", "C0012634#ent", "<e2>"], "h": {"id": "C1564278", "name": "C1564278#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["The", "C0796136#ent", "<e1>", "RRS", ")", "is", "characterized", "by", "hearing", "loss", "mental", "deterioration", "C0007758#ent", "<e2>", ",", "primary", "hypogonadism", "autosomal", "recessive", "."], "h": {"id": "C0796136", "name": "C0796136#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "C0003873#ent", "<e1>", "'", "operates", "as", "a", "modulator", "protein", "C1705628#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [10, 11]}}
{"token": ["Disruption", "of", "the", "C1417088#ent", "<e1>", "haploid", "S.", "cerevisiae", "mutants", "unable", "to", "grow", "on", "C0000975#ent", "<e2>", "and", "impaired", "in", "growth", "on", "glycerol", "plus", "lactate", "as", "carbon", "sources", "."], "h": {"id": "C1417088", "name": "C1417088#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [13, 14]}}
{"token": ["C1868714#ent", "<e1>", "an", "aggregate", "of", "symptoms", "that", "includes", "recurrent", "C0242429#ent", "<e2>", "foreign", "body", "sensation", "dysphagia", ",", "and/or", "facial", "pain", "a", "direct", "result", "of", "an", "elongated", "styloid", "process", "or", "calcified", "stylohyoid", "ligament"], "h": {"id": "C1868714", "name": "C1868714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242429", "name": "C0242429#ent", "pos": [9, 10]}}
{"token": ["C1868714#ent", "<e1>", "when", "an", "elongated", "styloid", "process", "or", "calcified", "stylohyoid", "ligament", "recurrent", "C0242429#ent", "<e2>", "foreign", "body", "sensation", "dysphagia", ",", "or", "facial", "pain"], "h": {"id": "C1868714", "name": "C1868714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242429", "name": "C0242429#ent", "pos": [12, 13]}}
{"token": ["Interactions", "of", "NAD-dependent", "dehydrogenases", "C1414968#ent", "<e1>", "GAPDH", ",", "and", "lactate", "dehydrogenase", "LDH", ")", "with", "C1420193#ent", "<e2>", "tubulin", "were", "characterized", "."], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [14, 15]}}
{"token": ["The", "C0671924#ent", "<e1>", "acetylates", "H3", "and", "also", "H4", ",", "whereas", "C0027203#ent", "<e2>", "specific", "for", "H3", "."], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["Studies", "in", "numerous", "HD", "models", "have", "shown", "that", "mutant", "huntingtin", "alters", "C0671924#ent", "<e1>", ",", "and", "indicate", "that", "aberrant", "activity", "of", "this", "C0027203#ent", "<e2>", "might", "be", "an", "underlying", "mechanism", "of", "transcriptional", "dysregulation", "HD", "."], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [21, 22]}}
{"token": ["The", "C0027203#ent", "<e1>", "was", "active", "with", "short", "chain", "aldehydes", "acetaldehyde", "and", "C0684287#ent", "<e2>", ")", "and", "NAD+", ",", "but", "not", "with", "NADP+", ",", "and", "the", "activity", "was", "higher", "in", "the", "mitochondrial", "pellet", "other", "cell", "fractions"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0684287", "name": "C0684287#ent", "pos": [11, 12]}}
{"token": ["Patients", "with", "atrial", "fibrillation", "C4049859#ent", "<e1>", ")", "present", "with", "symptoms", "of", "C0151744#ent", "<e2>", "exclusion", "of", "coronary", "artery", "disease"], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "PIAS3", "functions", "as", "a", "C1539895#ent", "<e1>", "C1706474#ent", "<e2>", "and", "also", "as", "a", "repressor", "of", "C1706474#ent", "<e2>", "transcriptional", "activity"], "h": {"id": "C1539895", "name": "C1539895#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706474", "name": "C1706474#ent", "pos": [8, 9]}}
{"token": ["The", "supports", "were", "successfully", "used", "for", "the", "C1367469#ent", "<e1>", "purification", "of", "a", "Lac", "repressor-beta-galactosidase", "fusion", "protein", ",", "C0001942#ent", "<e2>", "and", "calmodulin", "."], "h": {"id": "C1367469", "name": "C1367469#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [17, 18]}}
{"token": ["The", "SNAP", "effect", "was", "blunted", "by", "the", "inhibitor", "of", "soluble", "C0671566#ent", "<e1>", "LY-83,583", ")", "and", "the", "C0001645#ent", "<e2>", "of", "cGMP-dependent", "protein", "kinases", "H-9", ")", "."], "h": {"id": "C0671566", "name": "C0671566#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [16, 17]}}
{"token": ["Statins", "increased", "C1706243#ent", "<e1>", "which", "was", "inhibited", "by", "mevalonate", ",", "farnesylpyrophosphate", ",", "or", "C0210158#ent", "<e2>", "."], "h": {"id": "C1706243", "name": "C1706243#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0210158", "name": "C0210158#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "the", "enzymatically", "active", "intracellular", "portion", "of", "C1870006#ent", "<e1>", "is", "sufficient", "to", "allow", "C0021699#ent", "<e2>", "signaling", "."], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [8, 9]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [14, 15]}}
{"token": ["This", "will", "provide", "theory", "basis", "for", "C1420489#ent", "<e1>", "regarded", "as", "a", "candidate", "C0017337#ent", "<e2>", "in", "pig", "carcass", "and", "growth", "traits"], "h": {"id": "C1420489", "name": "C1420489#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["The", "African", "American", "Study", "of", "Kidney", "Disease", "and", "Hypertension", "was", "a", "multicenter", "trial", "African", "Americans", "C0020538#ent", "<e1>", "to", "an", "angiotensin-converting", "enzyme", "inhibitor", "ramipril", ")", ",", "a", "beta-blocker", "(", "C0724633#ent", "<e2>", ",", "or", "a", "calcium", "channel", "blocker", "amlodipine", "besylate", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0724633", "name": "C0724633#ent", "pos": [28, 29]}}
{"token": ["This", "indicates", "that", "no", "inhibitor", "is", "present", "in", "C0010206#ent", "<e1>", "plasmas", "and", "in", "the", "plasma", "of", "C0005779#ent", "<e2>", "the", "prothrombin", "complex", "for", "hemophilia", "BM", "plasma", "which", "does", "contain", "an", "inhibitor", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [16, 17]}}
{"token": ["We", "also", "report", "a", "prenatal", "identification", "of", "C1861923#ent", "<e1>", "male-to-female", "sex", "reversal", "a", "fetus", "with", "a", "de", "novo", "complex", "karyotype", ",", "C2751824#ent", "<e2>", ",", "t(4;7;8;17)(4qter-->4p15.1::17q25.1", "-", "->17qter;7qter-->7p15.3::4p15.1", "-", "->4pter;8pter-->8q12.1::7p15.3", "-", "->7pter;17pter-->17q25.1::8q12.1", "-", "->8qter", ")", "."], "h": {"id": "C1861923", "name": "C1861923#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2751824", "name": "C2751824#ent", "pos": [21, 22]}}
{"token": ["The", "investigation", "showed", "that", "symptoms", "such", "as", "headache", ",", "C0030196#ent", "<e1>", "diarrhoea", "were", "experienced", "more", "frequently", "among", "children", "with", "C0079423#ent", "<e2>", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079423", "name": "C0079423#ent", "pos": [19, 20]}}
{"token": ["A", "small", "number", "of", "comparative", "studies", "shown", "flunarizine", "to", "be", "at", "least", "as", "effective", "as", "pizotifen", "in", "C0154723#ent", "<e1>", "prophylaxis", ",", "and", "in", "a", "longer", "term", "study", "effective", "as", "C0008803#ent", "<e2>", "in", "vertigo", "of", "central", "origin"], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0008803", "name": "C0008803#ent", "pos": [29, 30]}}
{"token": ["C1705592#ent", "<e1>", "expression", "was", "significantly", "lower", "in", "clones", "expressing", "the", "dominant-negative", "C0597298#ent", "<e2>", "and", "significantly", "increased", "in", "clones", "expressing", "the", "activated", "C0597298#ent", "<e2>", "(", "P", "<", "0.05", "for", "both", ")", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "the", "value", "of", "combinations", "of", "cervical", "interleukin-6", "IL-6", ")", ",", "cervical", "interleukin-8", "C1705592#ent", "<e1>", ")", ",", "the", "phosphorylated", "C0597298#ent", "<e2>", "of", "insulin-like", "growth-factor", "binding", "protein-1", "IGFBP-1", ")", ",", "and", "cervical", "ultrasonography", "the", "prediction", "of", "preterm", "birth"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [20, 21]}}
{"token": ["The", "detection", "of", "this", "C0597298#ent", "<e1>", "in", "spontaneously", "differentiating", "SH-SY5Y", "neuroblastoma", "cells", "and", "in", "nerve", "growth", "C1705592#ent", "<e2>", "PC12", "cells", "links", "this", "C0597298#ent", "<e1>", "to", "neural", "differentiation"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [4, 5]}}
{"token": ["Growth", "of", "D.", "gigas", "on", "a", "formate-sulfate", "medium", "containing", "C0000975#ent", "<e1>", "resulted", "in", "a", "10-fold", "increase", "in", "C0016570#ent", "<e2>", "a", "doubling", "of", "c-type", "cytochromes", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016570", "name": "C0016570#ent", "pos": [17, 18]}}
{"token": ["Both", "MPRs", "46", "and", "300", "were", "found", "to", "have", "a", "minor", "but", "distinct", "preference", "for", "forms", "of", "C0072034#ent", "<e1>", "other", "lysosomal", "proteins", "oligosaccharides", "with", "two", "C0001109#ent", "<e2>", "."], "h": {"id": "C0072034", "name": "C0072034#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001109", "name": "C0001109#ent", "pos": [25, 26]}}
{"token": ["The", "transgenic", "rice", "showed", "higher", "tolerance", "to", "toxic", "concentrations", "C0022956#ent", "<e1>", "(", "MG", ")", "and", "C1412125#ent", "<e2>", "."], "h": {"id": "C0022956", "name": "C0022956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [15, 16]}}
{"token": ["Gillberg", "&", "Gillberg", "'s", "operational", "criteria", "for", "its", "definition", "are", "used", "to", "C1875400#ent", "<e1>", "three", "cases", "of", "the", "C0039082#ent", "<e2>", "presenting", "over", "a", "single", "year", "to", "a", "mental", "handicap", "service", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}}
{"token": ["C0011525#ent", "<e1>", "REases", ")", "are", "C0011519#ent", "<e2>", "that", "cleave", "DNA", "sequences", "remarkable", "specificity", "."], "h": {"id": "C0011525", "name": "C0011525#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [5, 6]}}
{"token": ["C0007286#ent", "<e1>", "a", "very", "common", "complication", "of", "the", "mucopolysaccharidoses", "and", "C0033788#ent", "<e2>", "should", "be", "actively", "looked", "for", "in", "affected", "patients", "."], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0033788", "name": "C0033788#ent", "pos": [10, 11]}}
{"token": ["Five", "children", "(", "3", "with", "C0007286#ent", "<e1>", "and", "1", "each", "with", "C0033788#ent", "<e2>", "juvenile", "cutaneous", "mucinosis", ")", "had", "bilateral", "disease"], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0033788", "name": "C0033788#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "C0118168#ent", "<e1>", "can", "lower", "the", "blood", "pressure", "reduce", "the", "C3887648#ent", "<e2>", "pressor", "response", "and", "lower", "the", "cardiac", "baroreflex", "to", "C3887648#ent", "<e2>", "."], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [13, 14]}}
{"token": ["These", "mutations", "either", "abolished", "(", "C0919496#ent", "<e1>", "and", "HES-1", ")", "or", "created", "(", "C1335233#ent", "<e2>", ")", "transcription-factor", "binding", "sites", "in", "the", "development", "and", "differentiation", "of", "neuronal", "systems"], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335233", "name": "C1335233#ent", "pos": [13, 14]}}
{"token": ["Glucose-6-phosphate", "dehydrogenase", "G6PD", ";", "E.C.1.1.1.49", ")", "deficiency", "is", "the", "most", "common", "human", "C0520572#ent", "<e1>", ";", "more", "than", "300", "different", "biochemical", "variants", "of", "the", "C0027203#ent", "<e2>", "have", "been", "described", "."], "h": {"id": "C0520572", "name": "C0520572#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [23, 24]}}
{"token": ["While", "the", "etiology", "of", "C0015230#ent", "<e1>", "is", "still", "unclear", ",", "a", "mild", "form", "of", "C2349411#ent", "<e2>", "partial", "dysautonomia", "or", "beta-receptor", "hypersensitivity", "been", "suggested", "for", "the", "pathophysiology", "of", "this", "disorder", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2349411", "name": "C2349411#ent", "pos": [14, 15]}}
{"token": ["Nonviral", "liver", "disorders", "defined", "as", "elevated", "transaminases", "(", "GOT", ">", "76", "IU/liter", "or", "C0001899#ent", "<e1>", ">", "86", "IU/liter", ",", "while", "negative", "for", "C0019163#ent", "<e2>", "C", "markers", "282", "cases", ")", "."], "h": {"id": "C0001899", "name": "C0001899#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [22, 23]}}
{"token": ["The", "results", "from", "patients", "with", "amyotrophic", "lateral", "sclerosis", "compared", "with", "those", "obtained", "from", "patients", "with", "other", "types", "of", "C0085084#ent", "<e1>", "patients", "with", "autoimmune", "and", "C0751871#ent", "<e2>", "and", "normal", "subjects"], "h": {"id": "C0085084", "name": "C0085084#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0751871", "name": "C0751871#ent", "pos": [24, 25]}}
{"token": ["This", "may", "be", "partly", "because", "of", "a", "protective", "effect", "circumcision", "on", "other", "sexually", "transmitted", "infections", "C0036916#ent", "<e1>", ")", ",", "especially", "those", "causing", "C0151281#ent", "<e2>", "but", "evidence", "for", "such", "protection", "is", "unclear", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0151281", "name": "C0151281#ent", "pos": [22, 23]}}
{"token": ["Donovanosis", "is", "a", "C0036916#ent", "<e1>", "infection", "which", "presents", "with", "C0151281#ent", "<e2>", "inguinal", "lymphadenopathy"], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0151281", "name": "C0151281#ent", "pos": [9, 10]}}
{"token": ["Both", "oral", "C0002575#ent", "<e1>", "and", "aerosol", "C0025573#ent", "<e2>", "produced", "significant", "bronchodilatation", "measured", "by", "forced", "expiratory", "volume", "in", "1", "second", "(", "FEV1", ")", "."], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025573", "name": "C0025573#ent", "pos": [6, 7]}}
{"token": ["The", "Saccharomyces", "cerevisiase", "protein", "phosphatase", "Fcp1", "has", "been", "implicated", "in", "the", "regulation", "of", "transcription", "by", "C0035680#ent", "<e1>", "and", "is", "encoded", "by", "the", "essential", "gene", "C1413790#ent", "<e2>", "."], "h": {"id": "C0035680", "name": "C0035680#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1413790", "name": "C1413790#ent", "pos": [24, 25]}}
{"token": ["C0035326#ent", "<e1>", "results", "as", "these", "C0991617#ent", "<e2>", "polymerize", "on", "exposure", "to", "ions", "in", "blood", "."], "h": {"id": "C0035326", "name": "C0035326#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [5, 6]}}
{"token": ["Among", "these", "are", "ccpA", "(", "encoding", "catabolite", "control", "protein", "A", ",", "bglS", "(", "encoding", "phospho-beta-glucosidase", ")", ",", "and", "several", "C0017337#ent", "<e1>", "from", "the", "Leloir", "pathway", "C1418864#ent", "<e2>", "proteins", "presumably", "essential", "for", "lactose", "metabolism"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418864", "name": "C1418864#ent", "pos": [25, 26]}}
{"token": ["After", "progressive", "destruction", "and", "narrowing", "of", "the", "C0158266#ent", "<e1>", "spondylitis", "and", "C0012624#ent", "<e2>", "results", "in", "subluxation", "and", "fusion", "of", "vertebral", "bodies", "square", "anterior", "corners", "."], "h": {"id": "C0158266", "name": "C0158266#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012624", "name": "C0012624#ent", "pos": [11, 12]}}
{"token": ["C0019342#ent", "<e1>", "be", "treated", "with", "acyclovir", ",", "valaciclovir", ",", "or", "C0209227#ent", "<e2>", "."], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0209227", "name": "C0209227#ent", "pos": [10, 11]}}
{"token": ["Three", "antiviral", "medications", "been", "shown", "to", "provide", "clinical", "benefit", "the", "treatment", "of", "C0019342#ent", "<e1>", "acyclovir", ",", "valacyclovir", "and", "C0209227#ent", "<e2>", "."], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0209227", "name": "C0209227#ent", "pos": [18, 19]}}
{"token": ["Five", "patients", "requiring", "dialysis", "for", "C0155919#ent", "<e1>", "uremia", "from", "severe", "C1306889#ent", "<e2>", "surgical", "revascularization"], "h": {"id": "C0155919", "name": "C0155919#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1306889", "name": "C1306889#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "a", "45-year-old", "man", "with", "C0754188#ent", "<e1>", "and", "end-stage", "renal", "insufficiency", "to", "C0017668#ent", "<e2>", "who", "developed", "therapy-resistant", "encephalopathy", "with", "intermittently", "high", "ammonia", "levels"], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [13, 14]}}
{"token": ["These", "results", "extend", "the", "hypothesis", "of", "a", "pathogenic", "role", "of", "C.", "pneumoniae", "C0003850#ent", "<e1>", "to", "include", "also", "C0428796#ent", "<e2>"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0428796", "name": "C0428796#ent", "pos": [17, 18]}}
{"token": ["A", "62-year-old", "man", "presented", "with", "C0155300#ent", "<e1>", ",", "a", "cranial", "bruit", "and", "a", "partial", "C0028866#ent", "<e2>"], "h": {"id": "C0155300", "name": "C0155300#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028866", "name": "C0028866#ent", "pos": [14, 15]}}
{"token": ["Ophthalmological", "problems", "as", "C0155300#ent", "<e1>", ",", "loss", "of", "visual", "acuity", "and", "C0028866#ent", "<e2>", "common", "in", "patients", "with", "shunt", "malfunctions"], "h": {"id": "C0155300", "name": "C0155300#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028866", "name": "C0028866#ent", "pos": [11, 12]}}
{"token": ["C1419651#ent", "<e1>", "offers", "the", "distinct", "advantage", "of", "working", "well", "in", "both", "C1864824#ent", "<e2>", "and", "formalin-fixed", "tissues", "and", "seemingly", "not", "marking", "epithelial", "neoplasms"], "h": {"id": "C1419651", "name": "C1419651#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1864824", "name": "C1864824#ent", "pos": [11, 12]}}
{"token": ["With", "C2987364#ent", "<e1>", "CDC28", ",", "filament", "formation", "induced", "by", "C0268281#ent", "<e2>", "overexpression", "was", "markedly", "decreased", "in", "a", "SWE1", "deletion", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268281", "name": "C0268281#ent", "pos": [9, 10]}}
{"token": ["The", "oxidative", "clearance", "of", "metoprolol", ",", "C0087093#ent", "<e1>", "and", "bufuralol", "is", "regulated/influenced", "by", "the", "C3887685#ent", "<e2>"], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [14, 15]}}
{"token": ["C0087093#ent", "<e1>", "is", "metabolized", "by", "the", "polymorphic", "cytochrome", "P450", "2D6", "enzyme", "C3887685#ent", "<e2>", ")", "."], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "a", "role", "in", "C0033581#ent", "<e1>", "in", "dermatological", "disorders", "by", "increased", "cell", "turnover", "been", "suggested", "for", "this", "C0030946#ent", "<e2>", "."], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [18, 19]}}
{"token": ["In", "C0033581#ent", "<e1>", "as", "rheumatoid", "arthritis", "functions", "of", "chondrocytes", "including", "synthesis", "of", "matrix", "proteins", "C0030946#ent", "<e2>", "are", "altered", "through", "interactions", "with", "cells", "of", "the", "infiltrating", "pannus", "."], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [14, 15]}}
{"token": ["We", "assessed", "C1426677#ent", "<e1>", "antioxidant", "levels", "by", "measuring", "the", "catalase", "and", "superoxide", "dismutase", "C1704945#ent", "<e2>", ")", "activity", "and", "the", "intracellular", "concentrations", "of", "total", "glutathione", ",", "ascorbic", "acid", "and", "alpha-tocopherol", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [13, 14]}}
{"token": ["2", ")", "In", "C1426677#ent", "<e1>", "and", "EN", ",", "Mn", "C1704945#ent", "<e2>", "levels", "well", "correlated", "with", "NSE", "or", "S-100b", "levels", "which", "are", "the", "markers", "of", "nervous", "tissue", "damages", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [9, 10]}}
{"token": ["A", "family", "is", "presented", "with", "short", "stature", "femoral", "epiphyseal", "dysplasia", "mild", "vertebral", "changes", ",", "and", "C0018784#ent", "<e1>", "inherited", "as", "an", "C2936739#ent", "<e2>", "."], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [20, 21]}}
{"token": ["AT", "is", "a", "multisystem", ",", "autosomal", "recessive", "disorder", "by", "progressive", "C0007758#ent", "<e1>", "oculocutaneous", "telangiectasia", "and", "increased", "susceptibility", "to", "recurrent", "C0035243#ent", "<e2>", "cancer", "predisposition"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [19, 20]}}
{"token": ["The", "type", "of", "complication", "is", "linked", "to", "the", "age", ":", "in", "children", ",", "bacterial", "infection", "skin", "lesions", "C0007758#ent", "<e1>", "more", "frequent", "while", "lower", "C0035243#ent", "<e2>", "Reye", "syndrome", "encephalitis", "are", "less", "common", "."], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [23, 24]}}
{"token": ["In", "contrast", ",", "C1561643#ent", "<e1>", "patients", "had", "a", "normal", "BMC/muscle", "C0751039#ent", "<e2>", "ratio", ",", "suggesting", "that", "their", "musculoskeletal", "system", "adapted", "normally", "to", "their", "(", "decreased", ")", "body", "size"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [10, 11]}}
{"token": ["At", "37", "degrees", "C", ",", "the", "slopes", "with", "C0040879#ent", "<e1>", "were", "much", "reduced", ",", "indicating", "that", "the", "C0013227#ent", "<e2>", "may", "have", "a", "selective", "action", "on", "a", "subclass", "of", "central", "benzodiazepine", "receptors"], "h": {"id": "C0040879", "name": "C0040879#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "a", "regulatory", "role", "C1366512#ent", "<e1>", "in", "parallel", "insulin", "response", "pathways", "including", "C1136240#ent", "<e2>", "ubiquitin", "ligase", "Cbl", ",", "or", "mitogen-activated", "protein", "kinase", "p38", "not", "observed", "."], "h": {"id": "C1366512", "name": "C1366512#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136240", "name": "C1136240#ent", "pos": [14, 15]}}
{"token": ["They", "also", "showed", "significant", "increases", "in", "the", "stimulation", "index", "response", "to", "the", "mitogen", "phytohemagglutinin", "C0030779#ent", "<e1>", ")", ",", "percentage", "of", "peripheral", "blood", "neutrophils", "C0023899#ent", "<e2>", "EROD", "induction", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [23, 24]}}
{"token": ["Studies", "were", "performed", "during", "and", "after", "surgery", "in", "19", "patients", "undergoing", "aorta-coronary", "bypass", "grafting", "C4020725#ent", "<e1>", "in", "6", "additional", "patients", "having", "aortic", "valve", "replacement", "isolated", "C1260873#ent", "<e2>"], "h": {"id": "C4020725", "name": "C4020725#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1260873", "name": "C1260873#ent", "pos": [25, 26]}}
{"token": ["Three", "cases", "are", "reported", "of", "C0009447#ent", "<e1>", "males", "with", "recurrent", "Campylobacter", "jejuni", "C0036690#ent", "<e2>", "and", "erysipelas-like", "cellulitis", "without", "diarrhoea", "."], "h": {"id": "C0009447", "name": "C0009447#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [12, 13]}}
{"token": ["While", "the", "noncatecholamine", "inotropics", "such", "as", "C0128513#ent", "<e1>", "may", "provide", "symptomatic", "relief", "in", "severe", "C0018802#ent", "<e2>", "they", "also", "increase", "heart", "rate", "induce", "ventricular", "arrhythmias", "are", "associated", "with", "one-year", "mortality", "rates"], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}}
{"token": ["This", "global", "improvement", "of", "diastolic", "function", "C0128513#ent", "<e1>", "a", "potentially", "useful", "drug", "in", "the", "oral", "treatment", "C0018802#ent", "<e2>"], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}}
{"token": ["The", "use", "of", "phosphodiesterase", "inhibitors", "as", "C0128513#ent", "<e1>", "in", "the", "treatment", "of", "severe", "C0018802#ent", "<e2>", "frequently", "restricted", "because", "they", "cause", "vasodilation", "and", "hypotension", "."], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["We", "evaluated", "contemporarily", "serum", "alpha", "beta", "chemokines", "patients", "with", "newly", "diagnosed", "C0036421#ent", "<e1>", "SSc", ")", "in", "the", "presence", "or", "absence", "of", "autoimmune", "thyroiditis", "C0004135#ent", "<e2>", ")", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [23, 24]}}
{"token": ["C0175702#ent", "<e1>", "WS", ")", "is", "a", "malformation", "syndrome", "characterized", "by", "cardiovascular", "disease", "supravalvular", "aortic", "stenosis", "C0345030#ent", "<e2>", ",", "facial", "dysmorphism", "growth/developmental", "delay", "and", "now", "is", "known", "to", "be", "caused", "by", "deletion", "of", "elastin", "gene", "other", "contiguous", "genes", "at", "chromosome", "7"], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0345030", "name": "C0345030#ent", "pos": [15, 16]}}
{"token": ["The", "assignment", "of", "betaine", "was", "confirmed", "by", "two-dimensional", "1H", "NMR", "studies", "of", "urine", "obtained", "from", "two", "adults", "with", "C0019880#ent", "<e1>", "receiving", "treatment", "with", "C0005304#ent", "<e2>"], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0005304", "name": "C0005304#ent", "pos": [23, 24]}}
{"token": ["In", "a", "3-year-old", "mentally", "retarded", "girl", "with", "C0019880#ent", "<e1>", "due", "to", "5,10-methylenetetrahydrofolate", "reductase", "deficiency", "different", "therapeutic", "approaches", "treatment", "with", "C0005304#ent", "<e2>", "(", "15", "-", "20", "g/day", ")", "resulted", "in", "a", "satisfactory", "biochemical", "response"], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0005304", "name": "C0005304#ent", "pos": [19, 20]}}
{"token": ["Although", "both", "Wnt", "and", "C1367721#ent", "<e1>", "glycogen", "synthase", "kinase", "3beta", "activation", "of", "epidermal", "growth", "factor", "receptor", "not", "stabilize", "C1332803#ent", "<e2>", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "whether", "C2826358#ent", "<e1>", "human", "megakaryocyte", "growth", "development", "factor", "PEG-rHuMGDF", ")", "affected", "5-fluorouracil-induced", "C0040034#ent", "<e2>", "without", "inducing", "more", "severe", "intimal", "thickening", "injury", "to", "rat", "carotid", "arteries"], "h": {"id": "C2826358", "name": "C2826358#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [14, 15]}}
{"token": ["After", "eliminating", "all", "other", "C0949690#ent", "<e1>", ",", "we", "studied", "210", "cases", "of", "C0263852#ent", "<e2>"], "h": {"id": "C0949690", "name": "C0949690#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0263852", "name": "C0263852#ent", "pos": [12, 13]}}
{"token": ["Seven", "years", "after", "a", "cadaver", "kidney", "transplantation", "33-year-old", "man", "presented", "with", "a", "monoclonal", "gammopathy", "complicated", "by", "C0268381#ent", "<e1>", "expressed", "as", "a", "sicca", "syndrome", "C0272247#ent", "<e2>", "that", "ultimately", "developed", "into", "multiple", "myeloma"], "h": {"id": "C0268381", "name": "C0268381#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0272247", "name": "C0272247#ent", "pos": [23, 24]}}
{"token": ["To", "evaluate", "the", "experimental", "induction", "of", "C0423361#ent", "<e1>", "PVD", ")", "by", "intravitreous", "injection", "of", "C1615665#ent", "<e2>", "and", "perfluoroethane", "(", "C(2)F(6", ")", ")", "."], "h": {"id": "C0423361", "name": "C0423361#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1615665", "name": "C1615665#ent", "pos": [14, 15]}}
{"token": ["Patients", "complained", "of", "sleeplessness", ",", "itching", ",", "C0018681#ent", "<e1>", ",", "palpitation", ",", "apathy", ",", "akinesis", ",", "leanness", ",", "C0459830#ent", "<e2>", "so", "on", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0459830", "name": "C0459830#ent", "pos": [18, 19]}}
{"token": ["Initially", ",", "the", "cochlear", "implantation", "recommended", "to", "patients", "totally", "deaf", "following", "a", "trauma", ",", "a", "C1285162#ent", "<e1>", "the", "inner", "ear", "a", "C0025297#ent", "<e2>", "or", "the", "use", "of", "ototoxic", "drugs", "."], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [21, 22]}}
{"token": ["Combinations", "of", "C0030883#ent", "<e1>", "and", "C0072076#ent", "<e2>", "or", "phenobarbital", "and", "C0072076#ent", "<e2>", "interacted", "additively", "when", "subjected", "to", "the", "pentylenetetrazol", "(", "PTZ", ")", "minimal", "threshold", "seizure", "clonic", ")", "test", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072076", "name": "C0072076#ent", "pos": [5, 6]}}
{"token": ["However", ",", "no", "correlation", "is", "found", "between", "the", "percentage", "of", "C1366561#ent", "<e1>", "and", "CD86", "positive", "C3813124#ent", "<e2>", "in", "these", "same", "patients", "."], "h": {"id": "C1366561", "name": "C1366561#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [15, 16]}}
{"token": ["Expression", "of", "C1366561#ent", "<e1>", "and", "CD86", "on", "C3813124#ent", "<e2>", ",", "and", "of", "CD28", "and", "CTLA4", "on", "T", "cells", "was", "evaluated", "."], "h": {"id": "C1366561", "name": "C1366561#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [7, 8]}}
{"token": ["In", "vitro", "virus", "infection", "upregulated", "C1366561#ent", "<e1>", "and", "CD86", "expression", "in", "C3813124#ent", "<e2>", "of", "normal", "nonsmoking", "subjects", "but", "not", "on", "those", "of", "smokers", "."], "h": {"id": "C1366561", "name": "C1366561#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [11, 12]}}
{"token": ["C0082966#ent", "<e1>", "appears", "to", "be", "an", "effective", "alternative", "to", "other", "C0003195#ent", "<e2>", "rapid", "conversion", "of", "arrhythmias", "to", "normal", "sinus", "rhythm", "in", "hemodynamically", "stable", "patients", "."], "h": {"id": "C0082966", "name": "C0082966#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [10, 11]}}
{"token": ["This", "frequency", "measurement", "correlates", "with", "the", "behavior", "of", "AF", "and", "predicts", "the", "response", "to", "administration", "of", "C0082966#ent", "<e1>", ",", "a", "new", "C0003195#ent", "<e2>"], "h": {"id": "C0082966", "name": "C0082966#ent", "pos": [16, 17]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [21, 22]}}
{"token": ["Sequence", "alignment", "the", "mouse", "and", "human", "C0017337#ent", "<e1>", "revealed", "that", "the", "human", "HSPA1L", "and", "C3541976#ent", "<e2>", "C0017337#ent", "<e1>", "were", "orthologous", "to", "the", "mouse", "Hsc70", "t", "and", "Hsp70.3", "genes", ",", "respectively", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541976", "name": "C3541976#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "expression", "of", "cell-cycle", "proteins", "p53", ",", "Ki-67", "(", "MIB-1", ")", "and", "C0525036#ent", "<e1>", ",", "as", "well", "as", "HER-2/", "neu", "oncoprotein", "C2936882#ent", "<e2>", "and", "progesterone", "receptor", "investigated", "."], "h": {"id": "C0525036", "name": "C0525036#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [24, 25]}}
{"token": ["The", "search", "for", "additional", "diabetogenic", "genes", "revealed", "predisposing", "non-MHC", "genes", ",", "C1415868#ent", "<e1>", "and", "Iddm4", ",", "and", "a", "C0011847#ent", "<e2>", "protective", "gene", "Iddm5r", ",", "cosegregating", "with", "C0011847#ent", "<e2>", "in", "the", "BB/OK", "rat", "subline", "."], "h": {"id": "C1415868", "name": "C1415868#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [18, 19]}}
{"token": ["The", "main", "clinically", "used", "antidepressant", "drugs", "selective", "monoamine", "reuptake", "inhibitors", "including", "selective", "serotonin", "reuptake", "inhibitors", "citalopram", ",", "sertraline", ")", ",", "selective", "dopamine", "reuptake", "inhibitor", "C0028277#ent", "<e1>", ")", "and", "selective", "C1319313#ent", "<e2>", "reboxetine", ")", ",", "but", "they", "have", "various", "side", "effects"], "h": {"id": "C0028277", "name": "C0028277#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1319313", "name": "C1319313#ent", "pos": [29, 30]}}
{"token": ["The", "prolonged", "QT", "syndrome", "a", "serious", "and", "potentially", "lethal", "C0018799#ent", "<e1>", "should", "be", "considered", "in", "all", "girls", "with", "C0035372#ent", "<e2>"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035372", "name": "C0035372#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "the", "consequence", "of", "impaired", "Na", ",", "K-ATPase", "function", "or", "reduced", "subunit", "expression", "levels", "in", "C0022658#ent", "<e1>", "as", "cancer", ",", "tubulointerstitial", "fibrosis", "and", "C2721575#ent", "<e2>", "discussed", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C2721575", "name": "C2721575#ent", "pos": [25, 26]}}
{"token": ["We", "provide", "strong", "evidence", "that", "Gcn4p", "recruits", "the", "entire", "SWI/SNF", "complex", "its", "target", "genes", "C1412515#ent", "<e1>", "and", "SNZ1", "but", "that", "C1337050#ent", "<e2>", "is", "dispensable", "for", "Gcn4p", "binding", "to", "these", "promoters", "."], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337050", "name": "C1337050#ent", "pos": [20, 21]}}
{"token": ["Interestingly", ",", "Swp73p", "is", "necessary", "for", "efficient", "C1337050#ent", "<e1>", "recruitment", "at", "SNZ1", "but", "not", "at", "C1412515#ent", "<e2>", ",", "indicating", "distinct", "subunit", "requirements", "for", "C1337050#ent", "<e1>", "recruitment", "at", "different", "genes", "."], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1337050", "name": "C1337050#ent", "pos": [7, 8]}}
{"token": ["Herein", "we", "review", "our", "work", "on", "early", "neutrophil", "regulation", "C1705971#ent", "<e1>", ",", "the", "beta-thromboglobulin", "neutrophil-activating", "peptide", "2", "NAP-2", ")", "and", "its", "major", "C1335239#ent", "<e2>", "CTAP-III", ")", "."], "h": {"id": "C1705971", "name": "C1705971#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335239", "name": "C1335239#ent", "pos": [22, 23]}}
{"token": ["Only", "C3537320#ent", "<e1>", "could", "distinguish", "baseline", "C0004238#ent", "<e2>", "from", "C0004238#ent", "<e2>", "with", "adenosine", "."], "h": {"id": "C3537320", "name": "C3537320#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [6, 7]}}
{"token": ["They", "are", "chemotactic", "for", "human", "monocytes", "and", "activate", "them", "to", "produce", "C1705592#ent", "<e1>", ",", "TNF-alpha", ",", "and", "endogenous", "C3538735#ent", "<e2>", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538735", "name": "C3538735#ent", "pos": [18, 19]}}
{"token": ["This", "study", "was", "undertaken", "to", "investigate", "the", "C1705592#ent", "<e1>", "inductive", "activity", "of", "the", "macrophage", "migration", "inhibitory", "factor", "C3538735#ent", "<e2>", ")", "in", "RA", "synovial", "fibroblasts"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3538735", "name": "C3538735#ent", "pos": [17, 18]}}
{"token": ["A", "case", "of", "the", "C0206141#ent", "<e1>", "presenting", "with", "C0267448#ent", "<e2>", "described", "."], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0267448", "name": "C0267448#ent", "pos": [8, 9]}}
{"token": ["C0206141#ent", "<e1>", "and", "CEL-NOC", "are", "considered", "distinct", "from", "molecularly", "defined", "C0267448#ent", "<e2>", "such", "as", "those", "associated", "with", "activating", "mutations", "of", "PDGFR", "(", "PDGFRA", "and", "PDGFRB", ")", "and", "fibroblast", "growth", "factor", "receptor-1"], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0267448", "name": "C0267448#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "RA", "plus", "TNFalpha", "greatly", "enhanced", "the", "level", "of", "RNA", "Pol", "II", "phosphorylation", "on", "the", "C1415884#ent", "<e1>", "promoter", ",", "via", "synergistic", "recruitment", "C1415344#ent", "<e2>", "."], "h": {"id": "C1415884", "name": "C1415884#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415344", "name": "C1415344#ent", "pos": [23, 24]}}
{"token": ["A", "single", "sequence", "high", "identity", "to", "C1421567#ent", "<e1>", "and", "several", "other", "groups", "of", "sequences", "(", "Lal1", ",", "C1413081#ent", "<e2>", ",", "Lal3", ",", "Lal8", ",", "and", "Lal14", ")", "were", "isolated", "from", "L.", "alabamica", "."], "h": {"id": "C1421567", "name": "C1421567#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413081", "name": "C1413081#ent", "pos": [17, 18]}}
{"token": ["Previous", "measurements", "suggested", "that", "the", "intrinsic", "fluorescence", "of", "C0041260#ent", "<e1>", "might", "be", "useful", "for", "examining", "binding", "of", "C1417500#ent", "<e2>", "+", "ATP", "and", "antimonite", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [17, 18]}}
{"token": ["As", "an", "example", ",", "the", "method", "was", "applied", "to", "a", "patient", "with", "C1417325#ent", "<e1>", "whom", "the", "C0277565#ent", "<e2>", "tissue", "could", "clearly", "be", "distinguished", "from", "healthy", "reference", "values"], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [16, 17]}}
{"token": ["A", "lead", "structure", "1a", ")", "was", "discovered", "from", "the", "screening", "of", "the", "focused", "library", "that", "was", "based", "on", "the", "structure", "of", "our", "C0016411#ent", "<e1>", "the", "human", "C1332699#ent", "<e2>", "and", "CCR3", "receptors"], "h": {"id": "C0016411", "name": "C0016411#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1332699", "name": "C1332699#ent", "pos": [26, 27]}}
{"token": ["The", "worldwide", "use", "of", "C0050537#ent", "<e1>", "ASA", ")", "as", "an", "C0003419#ent", "<e2>", "including", "during", "pregnancy", ",", "prompted", "us", "to", "investigate", "its", "potentially", "deleterious", "effects", "that", "condition", "."], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [10, 11]}}
{"token": ["C0050537#ent", "<e1>", "the", "most", "widely", "used", "drug", "as", "C0003419#ent", "<e2>", ",", "analgesic", ",", "anti-inflammatory", "agent", "for", "secondary", "prevention", "thrombotic", "phenomena", "in", "the", "heart", ",", "brain", "and", "peripheral", "circulation"], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "it", "was", "shown", "that", "bovine", "C1413354#ent", "<e1>", "is", "a", "C0031686#ent", "<e2>", "and", "that", "both", "bovine", "and", "human", "BCNTs", "are", "phosphorylated", "by", "casein", "kinase", "II", "in", "vitro"], "h": {"id": "C1413354", "name": "C1413354#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [11, 12]}}
{"token": ["Rivastigmine", "has", "been", "demonstrated", "to", "improve", "cognition", "and", "neuropsychiatric", "symptoms", "in", "patients", "with", "C0752347#ent", "<e1>", "without", "worsening", "C0003405#ent", "<e2>", "features", "."], "h": {"id": "C0752347", "name": "C0752347#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [17, 18]}}
{"token": ["Premortem", "diagnosis", "C0752347#ent", "<e1>", "DLBD", ")", "is", "difficult", ",", "and", "knowledge", "of", "the", "C0003405#ent", "<e2>", "features", "of", "DLBD", "might", "facilitate", "the", "diagnosis", "."], "h": {"id": "C0752347", "name": "C0752347#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [13, 14]}}
{"token": ["The", "goal", "of", "this", "study", "was", "to", "compare", "the", "visual-perceptual", "performance", "of", "subjects", "with", "C0752347#ent", "<e1>", "with", "predominant", "psychosis", ",", "C0752347#ent", "<e1>", "with", "predominant", "C0003405#ent", "<e1>", "features", "and", "AD", "."], "h": {"id": "C0752347", "name": "C0752347#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [24, 25]}}
{"token": ["To", "compare", "plasma", "homocysteine", "concentrations", "among", "patients", "with", "C0206368#ent", "<e1>", "exfoliative", "glaucoma", "normal-tension", "glaucoma", "and", "normal", "control", "without", "vascular", "or", "C1290884#ent", "<e2>", "glaucoma", "."], "h": {"id": "C0206368", "name": "C0206368#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [20, 21]}}
{"token": ["To", "compare", "plasma", "homocysteine", "concentrations", "among", "patients", "with", "exfoliation", "syndrome", "C0206368#ent", "<e1>", "normal-tension", "glaucoma", "and", "normal", "control", "without", "vascular", "or", "C1290884#ent", "<e2>", "glaucoma", "."], "h": {"id": "C0206368", "name": "C0206368#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "in", "human", "KB", "epithelial", "cells", "from", "apoptosis", "by", "BCL-2", ",", "the", "C0667830#ent", "<e1>", "p20", "BAP31", ",", "inhibits", "egress", "of", "C1540081#ent", "<e2>", "and", "integrin-mediated", "cell", "."], "h": {"id": "C0667830", "name": "C0667830#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1540081", "name": "C1540081#ent", "pos": [21, 22]}}
{"token": ["Only", "wild-type", "C0663446#ent", "<e1>", "an", "active", "C0254251#ent", "<e2>", "able", "to", "hyperphosphorylate", "the", "C-terminal", "domain", "RNA", "polymerase", "II", "mediate", "Tat", "transactivation", "P-TEFb-depleted", "HeLa", "nuclear", "extract", "."], "h": {"id": "C0663446", "name": "C0663446#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0254251", "name": "C0254251#ent", "pos": [6, 7]}}
{"token": ["By", "introducing", "point", "mutations", "into", "the", "discoidin", "domain", "C1704844#ent", "<e1>", "at", "positions", "homologous", "to", "the", "C0152439#ent", "<e2>", "mutations", ",", "ligand", "binding", "epitopes", "in", "the", "discoidin", "domain", "C1704844#ent", "<e1>", "were", "mapped", "."], "h": {"id": "C0152439", "name": "C0152439#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704844", "name": "C1704844#ent", "pos": [8, 9]}}
{"token": ["Regardless", "of", "their", "slightly", "different", "algorithm", "the", "programs", "found", "succinate", "dehydrogenase", "complex", "subunit", "A", "C1419906#ent", "<e1>", ")", "to", "be", "the", "best", "individual", "C1412999#ent", "<e2>", "and", "C1419906#ent", "<e1>", "and", "phosphoglycerate", "kinase-1", "PGK1", ")", "as", "the", "most", "suitable", "combination", "."], "h": {"id": "C1419906", "name": "C1419906#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [22, 23]}}
{"token": ["Phosphorylation", "of", "C1431123#ent", "<e1>", "at", "Ser(431", ")", "did", "not", "alter", "the", "activity", "of", "C1431123#ent", "<e1>", "to", "phosphorylate", "itself", "or", "the", "C0079419#ent", "<e1>", "alter", "the", "amount", "of", "C1431123#ent", "<e1>", "associated", "with", "cell", "membranes"], "h": {"id": "C0079419", "name": "C0079419#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1431123", "name": "C1431123#ent", "pos": [2, 3]}}
{"token": ["Beta-blockers", "and", "particular", "C0054836#ent", "<e1>", "may", "prolong", "survival", "and", "decrease", "worsening", "C0018802#ent", "<e2>", "when", "used", "in", "combination", "with", "digoxine", ",", "diuretics", "and", "ACE", "inhibitors"], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}}
{"token": ["The", "C1709313#ent", "<e1>", "interfere", "with", "the", "function", "of", "C0249197#ent", "<e2>", ")", "by", "binding", "."], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0249197", "name": "C0249197#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "C1332817#ent", "<e1>", "-", "3'A", "variant", "was", "strongly", "associated", "with", "early-onset", "C0011847#ent", "<e2>", "in", "a", "recessive", "model", "(", "AA", "versus", "AG", "+", "GG", ",", "p", "=", "0.017", ")", "."], "h": {"id": "C1332817", "name": "C1332817#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [13, 14]}}
{"token": ["Pretreating", "macrophages", "with", "dibutyryl", "cyclic", "AMP", "retinoic", "acid", "not", "prime", "the", "cells", "to", "respond", "to", "the", "other", "agent", ";", "instead", ",", "both", "C0991617#ent", "<e1>", "must", "be", "present", "simultaneously", "to", "obtain", "the", "synergistic", "induction", "C0033679#ent", "<e2>", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0033679", "name": "C0033679#ent", "pos": [33, 34]}}
{"token": ["As", "the", "patient", "showed", "no", "complications", "prior", "to", "C0009774#ent", "<e1>", "we", "suspect", "that", "the", "C0042769#ent", "<e2>", "edema", "of", "the", "corneal", "flap", "which", "caused", "epithelial", "ingrowth", "the", "flap", "."], "h": {"id": "C0009774", "name": "C0009774#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [14, 15]}}
{"token": ["Most", "cases", "of", "C0009774#ent", "<e1>", "in", "adults", "are", "probably", "due", "to", "C0042769#ent", "<e2>", "but", "children", "are", "more", "likely", "to", "develop", "bacterial", "conjunctivitis", "they", "are", "viral", "forms"], "h": {"id": "C0009774", "name": "C0009774#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [11, 12]}}
{"token": ["The", "role", "of", "hereditary", "abnormalities", "C0014547#ent", "<e1>", "development", "is", "discussed", ",", "as", "are", "problems", "of", "differential", "diagnosis", "C0152222#ent", "<e2>", "other", "rare", "hereditary", "diseases", "combinations", "of", "ichthyosis", ",", "C0014547#ent", "<e1>", ",", "and", "intellect", "disturbances"], "h": {"id": "C0152222", "name": "C0152222#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [5, 6]}}
{"token": ["Quantitative", "RT-PCR", "that", "the", "expression", "of", "normal", "C0205775#ent", "<e1>", "mRNA", "decreased", "in", "their", "lymphocytes", ",", "while", "the", "C0121300#ent", "<e2>", "patient", "had", "more", "expression", "of", "mutant", "GTP", "cyclohydrolase", "I", "mRNA", "than", "his", "asymptomatic", "mother", "."], "h": {"id": "C0205775", "name": "C0205775#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0121300", "name": "C0121300#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "fish", "apparently", "express", "only", "a", "single", "C1332116#ent", "<e1>", "although", "in", "different", "species", ",", "this", "may", "be", "either", "C1704839#ent", "<e2>", "or", "ARNT2", "."], "h": {"id": "C1332116", "name": "C1332116#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704839", "name": "C1704839#ent", "pos": [20, 21]}}
{"token": ["Expression", "of", "the", "coactivators", "SRC-1", "and", "C0256079#ent", "<e1>", "which", "bind", "to", "C1418776#ent", "<e2>", ",", "also", "enhanced", "the", "responsiveness", "of", "the", "prolactin", "promoter", "PPARalpha", "."], "h": {"id": "C0256079", "name": "C0256079#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418776", "name": "C1418776#ent", "pos": [11, 12]}}
{"token": ["Patients", "were", "followed", "up", "3", "months", "after", "the", "ulcers", "healed", ",", "and", "44", "%", "who", "had", "been", "on", "C0053555#ent", "<e1>", "and", "72", "%", "on", "C0008783#ent", "<e2>", "had", "active", "ulcers", "no", "significant", ")", "."], "h": {"id": "C0053555", "name": "C0053555#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [24, 25]}}
{"token": ["Three", "were", "young", "athletes", "participating", "in", "competitive", "sport", ",", "one", "had", "trained", "intensively", "for", "years", "after", "C0032371#ent", "<e1>", "complicated", "by", "C0030486#ent", "<e2>", "."], "h": {"id": "C0032371", "name": "C0032371#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030486", "name": "C0030486#ent", "pos": [20, 21]}}
{"token": ["Two", "of", "them", "presented", "a", "C0032371#ent", "<e1>", "and", "two", "a", "C0030486#ent", "<e2>", "of", "Hodgkin", "in", "the", "irradiated", "region"], "h": {"id": "C0032371", "name": "C0032371#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030486", "name": "C0030486#ent", "pos": [10, 11]}}
{"token": ["The", "paradigm", "for", "the", "former", "is", "X-linked", "adrenoleukodystrophy", "by", "mutations", "in", "the", "C0162309#ent", "<e1>", ",", "for", "the", "latter", ",", "C0043459#ent", "<e2>", "by", "mutations", "in", "peroxin", "genes", "."], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [19, 20]}}
{"token": ["Subunits", "B", "C", "and", "3-ketoacyl-CoA", "thiolase", "detected", "in", "fibroblasts", "of", "controls", "and", "C0162309#ent", "<e1>", "patients", ",", "but", "not", "of", "C0043459#ent", "<e2>", "patients", "."], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [19, 20]}}
{"token": ["Using", "strict", "pathologic", "criteria", "the", "diagnosis", "of", "C0162309#ent", "<e1>", ",", "we", "find", "that", ",", "despite", "many", "clinical", "resemblances", ",", "C0162309#ent", "<e1>", "and", "the", "C0043459#ent", "<e1>", "are", "distinguishable", "on", "the", "basis", "of", "histology", "and", "peroxisomal", "biochemistry"], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [23, 24]}}
{"token": ["Among", "the", "affected", "genes", ",", "we", "show", "that", "suppressor", "of", "tumorigenicity", "7", "C1420445#ent", "<e1>", ")", "and", "nonmetastatic", "23", "(", "C0812204#ent", "<e2>", ")", "are", "direct", "targets", "of", "PRMT5-containing", "BRG1", "and", "hBRM", "complexes"], "h": {"id": "C1420445", "name": "C1420445#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812204", "name": "C0812204#ent", "pos": [19, 20]}}
{"token": ["To", "study", "the", "relationship", "between", "serum", "uric", "acid", "lipid", "fractions", "and", "coagulation", "factor", "VII", "C2732002#ent", "<e1>", ")", "in", "the", "elderly", ",", "we", "measured", "C1333523#ent", "<e2>", "FVIIc", ")", "."], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333523", "name": "C1333523#ent", "pos": [23, 24]}}
{"token": ["Finally", ",", "we", "found", "that", "C1427198#ent", "<e1>", "efficiently", "inhibited", "the", "phosphatidylinositol", "3-kinase", "signaling", "pathway", "sensitive", "cell", "lines", "that", "ectopic", "expression", "of", "a", "C0669365#ent", "<e2>", "active", "Akt", "mutant", "reduced", "C1427198#ent", "<e1>", "cytotoxicity", "in", "this", "cell", "line"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1427198", "name": "C1427198#ent", "pos": [5, 6]}}
{"token": ["This", "incident", "suggests", "that", "acute", "exposure", "to", "CFP", "is", "similar", "to", "other", "C0031428#ent", "<e1>", "exposures", "with", "relatively", "minor", "symptoms", "including", "C0270697#ent", "<e2>", ",", "irritation", "of", "mucous", "membranes", "and", "gastrointestinal", "symptoms"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [20, 21]}}
{"token": ["In", "an", "isolated", ",", "perfused", "rat", "heart", "preparation", "C0151814#ent", "<e1>", "addition", "of", "C0043317#ent", "<e2>", "the", "perfusion", "medium", "increased", "the", "incidence", "of", "reperfusion", "arrhythmias", "decreased", "the", "total", "duration", "of", "sinus", "rhythm", "during", "reperfusion", "."], "h": {"id": "C0151814", "name": "C0151814#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "that", "verapamil", "does", "not", "delay", "the", "transition", "from", "reversible", "to", "irreversible", "myocardial", "injury", "C0151814#ent", "<e1>", "the", "rabbit", ",", "which", "like", "the", "human", ",", "lacks", "C0043317#ent", "<e2>"], "h": {"id": "C0151814", "name": "C0151814#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [27, 28]}}
{"token": ["We", "have", "also", "gathered", "evidence", "that", "endo-", "and", "exocytosis", "of", "C1332804#ent", "<e1>", "be", "regulated", "by", "C0525678#ent", "<e2>", "and", "ras-related", "proteins", "addition", "to", "previously", "described", "trafficking", "systems"], "h": {"id": "C1332804", "name": "C1332804#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "whether", "these", "findings", "are", "applicable", "to", "clinical", "conditions", ",", "we", "examined", "the", "expression", "and", "cellular", "localization/co-localization", "C1705323#ent", "<e1>", ",", "c-Met", ",", "beta-catenin", ",", "EGFR", "and", "C1512127#ent", "<e2>", "in", "gallbladder", "cancer"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1512127", "name": "C1512127#ent", "pos": [27, 28]}}
{"token": ["These", "results", "suggested", "that", "C0087093#ent", "<e1>", "can", "adversely", "affect", "patients", "with", "C3714497#ent", "<e2>"], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3714497", "name": "C3714497#ent", "pos": [11, 12]}}
{"token": ["HA", "1004", "and", "C0001927#ent", "<e1>", "also", "relaxed", "the", "basal", "tracheal", "tone", ",", "whereas", "C0042523#ent", "<e2>", "and", "nifedipine", "were", "inactive", "."], "h": {"id": "C0001927", "name": "C0001927#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [13, 14]}}
{"token": ["Three", "of", "four", "patients", "were", "recorded", "as", "having", "lipaemic", "serum", "received", "propofol", ",", "however", "two", "of", "these", "patients", "along", "with", "the", "patient", "that", "received", "C0026056#ent", "<e1>", "also", "received", "C0733854#ent", "<e2>", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0733854", "name": "C0733854#ent", "pos": [28, 29]}}
{"token": ["C0025517#ent", "<e1>", "MBD", ")", ",", "or", "C0035579#ent", "<e2>", ",", "is", "common", "in", "very", "low", "birthweight", "infants"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [6, 7]}}
{"token": ["Non-responders", "to", "C0066477#ent", "<e1>", "generally", "did", "not", "respond", "to", "subsequent", "treatment", "with", "C0009079#ent", "<e2>", ",", "indicating", "that", "this", "group", "of", "patients", "was", "very", "treatment", "."], "h": {"id": "C0066477", "name": "C0066477#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "increased", "C0812382#ent", "<e1>", "the", "AP-1", "transcription", "factor", "family", "members", "FRA-1", "and", "C1623430#ent", "<e2>", "was", "observed", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [13, 14]}}
{"token": ["C0812382#ent", "<e1>", "AP-1", "transcription", "factor", "with", "increased", "expression", "of", "c-fos", "and", "C1623430#ent", "<e2>"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [11, 12]}}
{"token": ["Major", "source", "of", "ROS", "in", "ECs", "is", "a", "NADPH", "oxidase", "consists", "of", "Nox1", ",", "Nox2", ",", "Nox4", ",", "C0003693#ent", "<e1>", ",", "p22phox", ",", "p47phox", "and", "the", "C0751984#ent", "<e2>"], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [26, 27]}}
{"token": ["C1332766#ent", "<e1>", "associates", "with", "the", "Ran", ",", "C1422162#ent", "<e2>", ",", "and", "Importin-alpha", "nuclear", "import", "complexes", "immunoprecipitates", "of", "lysates", "from", "cells", "treated", "with", "agents", "."], "h": {"id": "C1332766", "name": "C1332766#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422162", "name": "C1422162#ent", "pos": [7, 8]}}
{"token": ["C1416427#ent", "<e1>", "is", "encoded", "in", "3", "C0017337#ent", "<e2>", "for", "3", "isozymes", "M", "L", "and", "E", "(", "H", ")", ",", "respectively", "."], "h": {"id": "C1416427", "name": "C1416427#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}}
{"token": ["In", "patients", "receiving", "imatinib", ",", "serum", "electrolytes", "be", "monitored", "and", "C0026821#ent", "<e1>", "treated", "by", "correction", "of", "serum", "calcium", ",", "or", "an", "empirical", "trial", "C0034422#ent", "<e2>"], "h": {"id": "C0026821", "name": "C0026821#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0034422", "name": "C0034422#ent", "pos": [23, 24]}}
{"token": ["Twenty-five", "adults", "with", "symptomatic", "type", "1", "C0017205#ent", "<e1>", "thirteen", "splenectomised", ")", "received", "C0102139#ent", "<e2>", "1.15", "U/kg", "three", "times", "a", "week", "(", "15", "U/kg", "per", "month", ")", "."], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0102139", "name": "C0102139#ent", "pos": [12, 13]}}
{"token": ["We", "present", "the", "case", "of", "a", "woman", "with", "C0017205#ent", "<e1>", "was", "being", "given", "C0102139#ent", "<e2>", "as", "enzyme", "replacement", "therapy"], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0102139", "name": "C0102139#ent", "pos": [13, 14]}}
{"token": ["We", "report", "the", "first", "characterization", "of", "a", "C0017205#ent", "<e1>", "genotype", "associated", "with", "development", "of", "neutralizing", "antibody", "C0102139#ent", "<e2>", ",", "in", "a", "patient", "affected", "with", "type", "3", "Gaucher", "disease"], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0102139", "name": "C0102139#ent", "pos": [16, 17]}}
{"token": ["When", "cultured", "with", "HGF", "(", "20ng/ml", ")", ",", "the", "cells", "expressed", "C1420631#ent", "<e1>", "on", "day", "3", "and", "C4284124#ent", "<e2>", "on", "day", "7", "."], "h": {"id": "C1420631", "name": "C1420631#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [17, 18]}}
{"token": ["In", "experiments", "reported", "here", ",", "we", "examined", "factors", "which", "may", "enhance", "or", "diminish", "the", "capacity", "of", "C1417725#ent", "<e1>", "to", "mediate", "this", "limited", "C2697656#ent", "<e2>", "release", "."], "h": {"id": "C1417725", "name": "C1417725#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [22, 23]}}
{"token": ["The", "inhibition", "of", "alpha-LPS", "uptake", "was", "offset", "in", "the", "presence", "of", "C1417725#ent", "<e1>", "by", "a", "simultaneous", "MAb-mediated", "increase", "in", "C2697656#ent", "<e2>", "uptake", "that", "was", "blocked", "by", "alpha-complement", "receptor", "1"], "h": {"id": "C1417725", "name": "C1417725#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [19, 20]}}
{"token": ["The", "calcium", "channel", "drugs", "C0012373#ent", "<e1>", ",", "verapemil", "and", "C0028066#ent", "<e2>", "stimulate", "the", "de", "novo", "formation", "of", "the", "30", "kDa", "\"", "stress", "protein", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [9, 10]}}
{"token": ["Verapamil", "(", "0.05", "-", "5", "microM", ")", ",", "C0012373#ent", "<e1>", "(", "0.2", "-", "20", "microM", ")", ",", "and", "C0028066#ent", "<e2>", "(", "0.3", "-", "30", "microM", ")", "produced", "concentration-dependent", "relaxation", "of", "bovine", "coronary", "artery"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [18, 19]}}
{"token": ["Only", "26.3", "%", "of", "Muscovite", "youth", "report", "being", "taught", "about", "C1456617#ent", "<e1>", "school", ",", "and", "just", "41.7", "%", "indicate", "discussion", "of", "C2963174#ent", "<e2>", "occurred", "with", "parents", "or", "other", "familial", "adults"], "h": {"id": "C1456617", "name": "C1456617#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C2963174", "name": "C2963174#ent", "pos": [21, 22]}}
{"token": ["A", "23-year-old", "woman", "with", "acute", "C0021345#ent", "<e1>", "presented", "with", "moderately", "severe", "C0857751#ent", "<e2>", "reported", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0857751", "name": "C0857751#ent", "pos": [11, 12]}}
{"token": ["A", "3-month-old", "infant", "with", "tetralogy", "of", "C1418436#ent", "<e1>", "and", "absent", "pulmonary", "valve", "C0040586#ent", "<e2>", "a", "radical", "repair"], "h": {"id": "C1418436", "name": "C1418436#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040586", "name": "C0040586#ent", "pos": [12, 13]}}
{"token": ["This", "ATP", "binding", "to", "C1419805#ent", "<e1>", "supports", "the", "notion", "of", "a", "C0120465#ent", "<e2>", "initiates", "the", "rapid", "inhibitory", "action", "of", "this", "enzyme", "during", "the", "primary", "step", "of", "vertebrate", "phototransduction", "."], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [11, 12]}}
{"token": ["Acidic", "residues", "within", "the", "C1417326#ent", "<e1>", "CD3", "subunits", "were", "essential", "for", "binding", "to", "the", "C0524891#ent", "<e2>"], "h": {"id": "C1417326", "name": "C1417326#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0524891", "name": "C0524891#ent", "pos": [14, 15]}}
{"token": ["The", "resulting", "env-mpl", "fusion", "C0029016#ent", "<e1>", "is", "responsible", "for", "an", "acute", "myeloproliferative", "disorder", "induced", "in", "mice", "by", "C1706151#ent", "<e2>", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706151", "name": "C1706151#ent", "pos": [17, 18]}}
{"token": ["C0034152#ent", "<e1>", "and", "p53", "were", "associated", "with", "undifferentiated", "carcinomas", "C1704467#ent", "<e2>", "and", "p53", "expression", "is", "reduced", "as", "disease", "stage", "in", "serous", "carcinomas", "C1704467#ent", "<e2>", "expression", "is", "increased", "as", "disease", "progresses", "in", "endometrioid", "carcinomas"], "h": {"id": "C0034152", "name": "C0034152#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [9, 10]}}
{"token": ["Human", "ADC", "is", "a", "460-amino", "acid", "protein", "that", "shows", "about", "48", "%", "identity", "to", "mammalian", "C0029282#ent", "<e1>", "C1417932#ent", "<e2>", ")", "but", "has", "no", "C1417932#ent", "<e2>", "activity", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [17, 18]}}
{"token": ["2", ")", "To", "study", "in", "an", "open", "fashion", "the", "efficacy", "of", "loop", "diuretic", "treatment", ",", "single", ",", "or", "in", "combination", "with", "an", "C0003015#ent", "<e1>", "or", "with", "C0037982#ent", "<e2>", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [26, 27]}}
{"token": ["C0166025#ent", "<e1>", "is", "a", "novel", "C0012544#ent", "<e2>", "approved", "in", "the", "USA", "for", "the", "treatment", "of", "Paget's", "disease", "and", "is", "under", "development", "for", "the", "treatment", "of", "PMO", "and", "CIO", "."], "h": {"id": "C0166025", "name": "C0166025#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [5, 6]}}
{"token": ["C0751003#ent", "<e1>", "of", "the", "sinus", "of", "Valsalva", "(", "C0080298#ent", "<e2>", ")", "is", "a", "rare", "cardiac", "disease", "may", "be", "acquired", "or", "congenital", "."], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [8, 9]}}
{"token": ["To", "evaluate", "the", "properties", "of", "the", "coexistent", "cardiac", "anomalies", "associated", "with", "C0751003#ent", "<e1>", "of", "sinus", "of", "Valsalva", "(", "C0080298#ent", "<e2>", ")", "and", "examine", "the", "long-term", "surgical", "results", "operation", "."], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [18, 19]}}
{"token": ["This", "case", "report", "a", "63", "year", "old", "woman", "with", "a", "nineteen", "year", "history", "of", "C0020179#ent", "<e1>", "had", "been", "successfully", "treated", "with", "C0039623#ent", "<e2>", "for", "9", "years", "."], "h": {"id": "C0020179", "name": "C0020179#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0039623", "name": "C0039623#ent", "pos": [21, 22]}}
{"token": ["There", "were", "16", "patients", "with", "pancreatic", "carcinomas", "7", "C0149521#ent", "<e1>", "5", "pseudocysts", ",", "2", "mucinous", "cystadenocarcinomas", "one", "each", "serous", "cystadenoma", "C0019562#ent", "<e2>", "and", "simple", "cyst", "of", "the", "pancreas", "."], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [20, 21]}}
{"token": ["C0388638#ent", "<e1>", "stimulation", "by", "C1705556#ent", "<e2>", "was", "inhibited", "by", "calphostin", "C", "chelerythrine", ",", "two", "PKC", "inhibitors", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [4, 5]}}
{"token": ["Inhibitors", "of", "phosphatidylinositide-specific", "PLC", "(", "U73122", ")", ",", "guanylylcyclase", "(", "ODQ", ")", ",", "PKA", "(", "Rp-cAMPS", ")", "or", "C0388638#ent", "<e1>", "(", "1-butanol", ")", "did", "not", "affect", "the", "action", "of", "C1705556#ent", "<e2>", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [29, 30]}}
{"token": ["The", "synthesis", "of", "two", "unidentified", "proteins", ",", "M(r", ")", "=", "14", "and", "41", "C1839259#ent", "<e1>", ",", "and", "the", "beta-subunit", "of", "the", "C0162381#ent", "<e2>", "substantially", "reduced", "after", "chilling", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162381", "name": "C0162381#ent", "pos": [21, 22]}}
{"token": ["Within", "the", "group", "of", "C0027868#ent", "<e1>", "fatigue", "has", "been", "reported", "by", "patients", "with", "post-polio", "syndrome", "C0026896#ent", "<e2>", "and", "Guillain-Barr\u00e9", "syndrome"], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "case", "of", "C0027868#ent", "<e1>", "overlap", "between", "C0026896#ent", "<e2>", "Lambert-Eaton", "syndrome", "LES", ")", "."], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [9, 10]}}
{"token": ["BMP2", ",", "a", "member", "of", "the", "C1366557#ent", "<e1>", "and", "the", "C1419771#ent", "<e2>", "(", "AML3/Cbfa1", ")", "transcription", "factor", ",", "a", "downstream", "BMP2", "effector", ",", "are", "regulatory", "signals", "for", "osteoblast", "differentiation"], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [10, 11]}}
{"token": ["To", "report", "the", "outcomes", "of", "laser", "in", "situ", "keratomileusis", "LASIK", ")", "in", "patients", "with", "a", "history", "of", "C0019357#ent", "<e1>", "HSV", ")", "or", "C0019364#ent", "<e2>", "HZO", ")", "."], "h": {"id": "C0019357", "name": "C0019357#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0019364", "name": "C0019364#ent", "pos": [22, 23]}}
{"token": ["When", "intradermally", "co-injected", "with", "C0006945#ent", "<e1>", ",", "atropine", "and", "4-DAMP", "but", "neither", "methoctramine", "nor", "C0030311#ent", "<e2>", "significantly", "inhibited", "the", "carbachol-induced", "scratching", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030311", "name": "C0030311#ent", "pos": [14, 15]}}
{"token": ["Ren-2", "rats", "(", "n", "=", "24", ")", "received", "either", "C0287041#ent", "<e1>", "(", "LOS", ")", ",", "quniapril", "(", "C0812297#ent", "<e2>", ")", ",", "or", "carvedilol", "(", "CARV", ")", "for", "11", "weeks", ",", "or", "no", "treatment"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812297", "name": "C0812297#ent", "pos": [17, 18]}}
{"token": ["In", "two", "children", "infection", "caused", "by", "C0302359#ent", "<e1>", "in", "two", "adults", ",", "who", "had", "underlying", "C0012634#ent", "<e2>", "which", "caused", "immunosuppression", ",", "by", "Shigella", "sonnei", "Shigella", "schmitzi", "."], "h": {"id": "C0302359", "name": "C0302359#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["C1412791#ent", "<e1>", "interneurons", "are", "electrically", "coupled", "to", "all", "N3", "phase", "(", "C1705085#ent", "<e2>", ",", "B4Cl", ",", "B8", ")", "feeding", "motor", "neurons"], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705085", "name": "C1705085#ent", "pos": [11, 12]}}
{"token": ["We", "report", "here", "that", "C0019163#ent", "<e1>", "replication", "and", "secretion", "can", "be", "significantly", "inhibited", "by", "C1422018#ent", "<e2>", "dominant", "negative", ",", "ATPase-defective", ",", "mutants", "K173Q", "and", "E228Q", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422018", "name": "C1422018#ent", "pos": [14, 15]}}
{"token": ["The", "C0291573#ent", "<e1>", "encodes", "for", "the", "C1667078#ent", "<e2>", "is", "a", "critical", "mediator", "of", "cell", "death", "embryonic", "development", "the", "mammalian", "brain", "."], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1667078", "name": "C1667078#ent", "pos": [6, 7]}}
{"token": ["These", "results", "demonstrated", "that", "C0291573#ent", "<e1>", ",", "but", "not", "ICE", ",", "is", "the", "predominant", "C1667078#ent", "<e2>", "mediates", "the", "Fas-mediated", "apoptosis", "of", "RA", "synovial", "cells"], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1667078", "name": "C1667078#ent", "pos": [14, 15]}}
{"token": ["Other", "C0038766#ent", "<e1>", "such", "as", "C0017642#ent", "<e2>", "and", "glibornuride", "and", "the", "sulphonylurea-related", "carboxylate", ",", "AZ-DF", "265", ",", "inhibited", "high", "affinity", "[3H]-glibenclamide", "binding", "with", "the", "potencies", "expected", "from", "their", "K+", "channel", "activity", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0017642", "name": "C0017642#ent", "pos": [5, 6]}}
{"token": ["C1299880#ent", "<e1>", "occurred", "as", "multiple", "and", "solitary", "lesions", "it", "was", "also", "associated", "with", "C0037928#ent", "<e2>", "."], "h": {"id": "C1299880", "name": "C1299880#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037928", "name": "C0037928#ent", "pos": [13, 14]}}
{"token": ["We", "propose", "that", "the", "selective", "degradation", "pathway", "involved", "in", "the", "regulation", "of", "the", "expression", "of", "cytokines", "and", "C0033713#ent", "<e1>", "is", "implicated", "in", "the", "rapid", "degradation", "of", "C1413235#ent", "<e2>", "mRNA", "in", "activated", "T", "lymphocytes"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413235", "name": "C1413235#ent", "pos": [26, 27]}}
{"token": ["C1419909#ent", "<e1>", "encodes", "a", "mitochondrial", "respiratory", "chain", "protein-the", "small", "subunit", "cytochrome", "b", "succinate-ubiquinone", "oxidoreductase", "C3273623#ent", "<e2>", ")", "."], "h": {"id": "C1419909", "name": "C1419909#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273623", "name": "C3273623#ent", "pos": [14, 15]}}
{"token": ["Osteoclasts", "(", "OC", ")", "are", "bone-resorbing", "cells", "derived", "from", "the", "C1413347#ent", "<e1>", "lineage", "in", "response", "to", "receptor", "activator", "C1417708#ent", "<e2>", "RANKL", ")", "."], "h": {"id": "C1413347", "name": "C1413347#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [18, 19]}}
{"token": ["Patients", "with", "C0339143#ent", "<e1>", "develop", "Graves'", "type", "hyperthyroidism", "followed", "immediately", "by", "transient", "C0020676#ent", "<e2>", "due", "to", "coexisting", "destructive", "autoimmune", "thyroiditis", "the", "early", "postpartum", "period", ",", "despite", "increasing", "TSAb", "activity", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [12, 13]}}
{"token": ["In", "C0339143#ent", "<e1>", "rate", "of", "recurrent", "hyperthyroidism", "was", "significantly", "higher", "that", "of", "posttreatment", "C0020676#ent", "<e2>", "lower", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [13, 14]}}
{"token": ["The", "first", "patient", "with", "C0339143#ent", "<e1>", "an", "extreme", "and", "C0020676#ent", "<e2>", "only", "few", "months", "after", "receiving", "this", "therapy", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "C0085191#ent", "<e1>", "seems", "to", "be", "clinically", "useful", "as", "an", "C0003216#ent", "<e2>"], "h": {"id": "C0085191", "name": "C0085191#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003216", "name": "C0003216#ent", "pos": [12, 13]}}
{"token": ["Because", "of", "the", "inaccessibility", "of", "the", "thick", "ascending", "limb", "C1428449#ent", "<e1>", ")", "to", "micropuncture", ",", "it", "has", "been", "difficult", "to", "evaluate", "the", "effects", "of", "ADH", "and", "C1417807#ent", "<e2>", "ANF", ")", "on", "C1428449#ent", "<e1>", "salt", "transport", "in", "vivo"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1428449", "name": "C1428449#ent", "pos": [9, 10]}}
{"token": ["C0022194#ent", "<e1>", "synthesized", "in", "vitro", "a", "polyadenylated", "mRNA", "as", "a", "C1305923#ent", "<e2>", "130", "kDa", ",", "which", "is", "somewhat", "larger", "than", "the", "mature", "enzyme", "of", "120", "kDa", "."], "h": {"id": "C0022194", "name": "C0022194#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [10, 11]}}
{"token": ["To", "evaluate", "whether", "abnormal", "production", "of", "type", "III", "collagen", "the", "characteristic", "biochemical", "feature", "of", "patients", "with", "the", "C0268338#ent", "<e1>", "consistently", "predisposes", "to", "C0026267#ent", "<e2>", "we", "evaluated", "the", "family", "of", "a", "proband", "with", "classic", "type", "IV", "Ehlers-Danlos", "syndrome"], "h": {"id": "C0268338", "name": "C0268338#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0026267", "name": "C0026267#ent", "pos": [22, 23]}}
{"token": ["L-Cycloserine", ",", "an", "inhibitor", "of", "C0057041#ent", "<e1>", "decreased", "both", "alanine", "and", "C0178474#ent", "<e2>", "production", ",", "suggesting", "that", "2-aminobutyrate", "synthesis", "share", "the", "same", "metabolic", "pathway", "alanine", "synthesis", "that", "2-oxobutyrate", "can", "act", "as", "a", "substrate", "for", "C0057041#ent", "<e1>"], "h": {"id": "C0057041", "name": "C0057041#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0178474", "name": "C0178474#ent", "pos": [11, 12]}}
{"token": ["The", "antibody", "to", "C2699249#ent", "<e1>", "reacted", "with", "a", "77", "C0026691#ent", "<e2>", "immunoblotting", "of", "a", "kidney", "lysate"], "h": {"id": "C2699249", "name": "C2699249#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [9, 10]}}
{"token": ["The", "existence", "of", "C0011991#ent", "<e1>", "hypokalaemia", "and", "C0020437#ent", "<e2>", "arouses", "suspicion", "of", "vipoma", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [7, 8]}}
{"token": ["A", "20-residue", "peptide", "analogue", "(", "IASGRTGRRNAIHDILVSSA", ")", "of", "the", "8000-dalton", "heat-stable", "cAMP-dependent", "protein", "kinase", "inhibitor", "efficient", "calcium-dependent", "binding", "calmodulin", ",", "with", "C1705240#ent", "<e1>", "approximately", "70", "nM", "when", "C2936886#ent", "<e2>", "is", "present", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [27, 28]}}
{"token": ["Magnesium", "shifts", "the", "drug", "absorbance", "spectrum", "longer", "wavelengths", "and", "displays", "a", "weak", "binding", "constant", "C1705240#ent", "<e1>", "=", "1mM", ")", ";", "no", "interaction", "with", "C2936886#ent", "<e2>", "was", "detected", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [23, 24]}}
{"token": ["The", "present", "paper", "deals", "with", "the", "comparative", "hemodynamic", "effect", "of", "digoxin", "and", "C0012258#ent", "<e1>", "on", "nine", "patients", "suffering", "from", "C0018801#ent", "<e2>"], "h": {"id": "C0012258", "name": "C0012258#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["When", "C0012258#ent", "<e1>", "is", "used", "in", "the", "treatment", "of", "C0018801#ent", "<e2>", "the", "very", "elderly", "patients", ",", "one", "should", "be", "aware", "of", "the", "possibility", "of", "digitoxin", "intoxication", "even", "at", "a", "low", "dose"], "h": {"id": "C0012258", "name": "C0012258#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [9, 10]}}
{"token": ["Although", "C2936739#ent", "<e1>", "inheritance", "has", "been", "suggested", "as", "an", "explanation", "of", "C0149781#ent", "<e2>", "available", "pedigree", "data", "are", "not", "adequate", "for", "statistical", "analysis"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0149781", "name": "C0149781#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "C1421451#ent", "<e1>", "is", "a", "substrate", "of", "C1707108#ent", "<e2>", "and", "phosphorylation", "of", "C1421451#ent", "<e1>", "contributes", "to", "M", "phase", "of", "the", "IF", "network", "."], "h": {"id": "C1707108", "name": "C1707108#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421451", "name": "C1421451#ent", "pos": [2, 3]}}
{"token": ["Furthermore", ",", "phosphorylation", "of", "purified", "plectin", "by", "C1707108#ent", "<e1>", "decreased", "plectin", "'s", "ability", "to", "interact", "with", "preassembled", "C1421451#ent", "<e2>", "filaments", "in", "vitro"], "h": {"id": "C1707108", "name": "C1707108#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421451", "name": "C1421451#ent", "pos": [17, 18]}}
{"token": ["A", "mutation", "analysis", "the", "human", "CR1", "promoter", "revealed", "that", "the", "binding", "sites", "TEL", "and", "C1335654#ent", "<e1>", "are", "necessary", "for", "the", "action", "of", "TEL", "and", "C0919449#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [14, 15]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0919449", "name": "C0919449#ent", "pos": [24, 25]}}
{"token": ["[D-Ala2,D-Leu5]-Enkephalin", "(", "DADLE", ")", "or", "[D-Pen2,D-Pen5]-enkephalin", "(", "C0525856#ent", "<e1>", ")", "were", "used", "as", "C0001644#ent", "<e2>", "dynorphin", "1-13", "Dyn", ")", "or", "U-50,488H", "were", "used", "as", "kappa-receptor", "agonists", "."], "h": {"id": "C0525856", "name": "C0525856#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [13, 14]}}
{"token": ["This", "study", "was", "designed", "to", "compare", "the", "inhalation", "of", "fenoterol", "and", "the", "inhalation", "of", "fenoterol", "plus", "C0134499#ent", "<e1>", "by", "a", "metered-dose", "inhaler", "holding", "chamber", "InspirEase", ")", "to", "relieve", "C0004096#ent", "<e2>", "."], "h": {"id": "C0134499", "name": "C0134499#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [28, 29]}}
{"token": ["C0001644#ent", "<e1>", "lymphocytes", "of", "C0282556#ent", "<e2>", "and", "non-asthmatic", "children", "and", "healthy", "adult", "volunteers", "was", "investigated", "with", "the", "radioligand", "125-iodocyanopindolol", "(", "ICYP", ")", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [4, 5]}}
{"token": ["A", "defect", "may", "exist", "in", "the", "coupling", "between", "C0001644#ent", "<e1>", "and", "postreceptor", "mechanisms", "in", "severely", "C0282556#ent", "<e2>", "lung", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [15, 16]}}
{"token": ["The", "outpatient", "C0265259#ent", "<e1>", "will", "rely", "on", "ambulatory", "payment", "classifications", "(", "C0033036#ent", "<e2>", ")", "to", "classify", "outpatient", "services"], "h": {"id": "C0265259", "name": "C0265259#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [11, 12]}}
{"token": ["In", "most", "cases", "the", "C1254351#ent", "<e1>", "involved", "was", "an", "C3536844#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536844", "name": "C3536844#ent", "pos": [9, 10]}}
{"token": ["Twenty-six", "patients", "with", "C0030567#ent", "<e1>", "given", "0.4", "to", "15", "mg", "of", "C0031008#ent", "<e2>", "daily", "in", "addition", "to", ",", "or", "as", "replacement", "for", ",", "levodopa", "or", "bromocriptine", "therapy"], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031008", "name": "C0031008#ent", "pos": [11, 12]}}
{"token": ["The", "colony-forming", "ability", "of", "these", "cells", "was", "compared", "to", "C2987364#ent", "<e1>", "Chinese", "hamster", "ovary", "cells", "conditions", "found", "to", "cause", "elevated", "C0022956#ent", "<e2>", "levels", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022956", "name": "C0022956#ent", "pos": [20, 21]}}
{"token": ["A", "54", "year", "old", "male", "developed", "plant", "C0039103#ent", "<e1>", "the", "knee", "followed", "five", "months", "later", "by", "C3898123#ent", "<e2>"], "h": {"id": "C0039103", "name": "C0039103#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3898123", "name": "C3898123#ent", "pos": [16, 17]}}
{"token": ["These", "alterations", "are", "similar", "to", "the", "defects", "seen", "in", "a", "human", "synpolydactyly", "suggesting", "that", "this", "C0039082#ent", "<e1>", ",", "which", "is", "associated", "with", "subtle", "mutation", "in", "C1415687#ent", "<e2>", "(", "ref", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415687", "name": "C1415687#ent", "pos": [25, 26]}}
{"token": ["Strain", "differences", "in", "C0003438#ent", "<e1>", "AT", ")", "activity", "and", "protein", "C", "C1418724#ent", "<e2>", ")", "levels", "were", "then", "identified", "."], "h": {"id": "C0003438", "name": "C0003438#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418724", "name": "C1418724#ent", "pos": [11, 12]}}
{"token": ["Harringtonine", "(", "HT", ")", "and", "homoharringtonine", "(", "HHT", ")", "are", "two", "C0949738#ent", "<e1>", "isolated", "from", "the", "bark", "of", "the", "evergreen", "tree", "Cephalotaxus", "hainanensis", "C1420713#ent", "<e2>", "in", "the", "1970s", "."], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420713", "name": "C1420713#ent", "pos": [23, 24]}}
{"token": ["Gene", "expression", "profiling", "two", "IMR32-DKK1", "clones", "showed", "that", "only", "a", "few", "genes", ",", "amongst", "which", "C1425052#ent", "<e1>", ",", "were", "up-regulated", "by", "C1414057#ent", "<e2>", "."], "h": {"id": "C1425052", "name": "C1425052#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414057", "name": "C1414057#ent", "pos": [21, 22]}}
{"token": ["The", "C2267032#ent", "<e1>", "PIR", ")", "and", "C0116190#ent", "<e2>", "(", "ENO", ")", "exert", "positive", "inotropic", "and", "vasodilating", "effects", "in", "patients", "with", "severe", "heart", "failure"], "h": {"id": "C2267032", "name": "C2267032#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0116190", "name": "C0116190#ent", "pos": [6, 7]}}
{"token": ["Despite", "inhibition", "of", "hypoxia", "and", "carbon", "dioxide", "retention", ",", "C0023212#ent", "<e1>", "occurrence", "of", "C0010054#ent", "<e2>", "delayed", "but", "not", "suppressed", "."], "h": {"id": "C0023212", "name": "C0023212#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [13, 14]}}
{"token": ["The", "wide", "availability", "of", "myocardial", "revascularization", "procedures", "a", "refinement", "of", "specific", "indications", "for", "revascularization", "whenever", "C0023212#ent", "<e1>", "the", "most", "prominent", "feature", "of", "C0010054#ent", "<e2>"], "h": {"id": "C0023212", "name": "C0023212#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [22, 23]}}
{"token": ["Thereafter", ",", "the", "expression", "of", "the", "basolateral", "chloride/bicarbonate", "exchangers", "AE1", "C1422673#ent", "<e1>", "and", "the", "C0379099#ent", "<e2>", "examined", "by", "northern", "hybridization", "immunoblot", "analysis", "immunofluorescence", "labelling"], "h": {"id": "C1422673", "name": "C1422673#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [14, 15]}}
{"token": ["Epitope", "mapping", "C3273275#ent", "<e1>", ",", "a", "fusion", "protein", "the", "C-terminal", "end", "C1539312#ent", "<e2>", ",", "suggested", "that", "the", "major", "antigenic", "epitopes", "for", "LABD", "and", "BP", "antibodies", "on", "the", "230-kDa", "antigen", "are", "different", "."], "h": {"id": "C3273275", "name": "C3273275#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [11, 12]}}
{"token": ["Endogenous", "C0027021#ent", "<e1>", ",", "and", "inducible", "enzyme", "in", "C1857728#ent", "<e2>", "was", "observed", "in", "two", "of", "the", "five", "tumors", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1857728", "name": "C1857728#ent", "pos": [8, 9]}}
{"token": ["Therefore", ",", "we", "examined", "the", "activity", "of", "C0021088#ent", "<e1>", "the", "rate-limiting", "enzyme", "for", "GTP", "biosynthesis", ",", "and", "C0061778#ent", "<e2>", "counteracts", "the", "effect", "of", "the", "synthetic", "enzyme"], "h": {"id": "C0021088", "name": "C0021088#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061778", "name": "C0061778#ent", "pos": [17, 18]}}
{"token": ["Nucleotide", "interconversion", "enzymes", "adenylosuccinate", "lyase", "EC", "4.3.2.2", ";", "adenylosuccinate", "synthetase", "EC", "6.3.4.4", ";", "C0021088#ent", "<e1>", "EC", "1.2.1.14", ";", "GMP", "synthetase", "EC", "6.3.5.2", "and", "C0061778#ent", "<e2>", "EC", "1.6.6.8", ")", "were", "not", "detected", "."], "h": {"id": "C0021088", "name": "C0021088#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0061778", "name": "C0061778#ent", "pos": [23, 24]}}
{"token": ["Recent", "investigations", "provided", "evidence", "that", "mutations", "in", "the", "C0017337#ent", "<e1>", "encoding", "the", "human", "matrix", "C3501221#ent", "<e2>", "Keutel", "syndrome", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3501221", "name": "C3501221#ent", "pos": [14, 15]}}
{"token": ["Five", "such", "C3541394#ent", "<e1>", "were", "examined", ":", "lactate", "dehydrogenase", "malate", "dehydrogenase", "adenylokinase", ",", "C1366530#ent", "<e2>", "and", "beta-hydroxyacyl-CoA", "dehydrogenase"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366530", "name": "C1366530#ent", "pos": [13, 14]}}
{"token": ["As", "the", "population", "of", "most", "developed", "countries", "ages", "so", "the", "prevalence", "of", "C0012634#ent", "<e1>", "such", "as", "age-related", "macular", "degeneration", "C0017921#ent", "<e2>", ")", "are", "likely", "to", "increase", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017921", "name": "C0017921#ent", "pos": [19, 20]}}
{"token": ["Additionally", ",", "C0286256#ent", "<e1>", "inhibited", "the", "increase", "in", "protein", "kinase", "A", "activity", "produced", "by", "C0175697#ent", "<e2>", "."], "h": {"id": "C0286256", "name": "C0286256#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [14, 15]}}
{"token": ["The", "lp3", "clone", "is", "similar", "to", "a", "group", "of", "C0017337#ent", "<e1>", "called", "C1332675#ent", "<e2>", "(", "ABA", "stress", "and", "ripening", ")", "C0017337#ent", "<e1>", "identified", "in", "several", "species", "."], "h": {"id": "C1332675", "name": "C1332675#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "mammary", "glands", "stimulated", "by", "C1418938#ent", "<e1>", "(", "PRL", ")", "express", "genes", "essential", "for", "serotonin", "biosynthesis", "tryptophan", "hydroxylase", "C1420870#ent", "<e2>", "]", "and", "aromatic", "amine", "decarboxylase", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [21, 22]}}
{"token": ["Dapsone", "syndrome", "is", "a", "rare", "hypersensitivity", "reaction", "C1639494#ent", "<e1>", "and", "is", "characterized", "by", "high", "fever", "papular", "or", "C0011606#ent", "<e2>", "progressing", "to", "liver", "toxicity", "and", "generalized", "lymphadenopathy", "resembling", "a", "mononucleosis", "infection"], "h": {"id": "C1639494", "name": "C1639494#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011606", "name": "C0011606#ent", "pos": [17, 18]}}
{"token": ["Light", "microscopic", "examination", "multifocal", "coagulative", "necrosis", "the", "C0023899#ent", "<e1>", ",", "catarrhal", "gastroenteritis", "tracheitis", "and", "C1535939#ent", "<e2>", ",", "and", "thymic", "atrophy"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [14, 15]}}
{"token": ["These", "stimuli", "induce", "Rel", "family", "C0812382#ent", "<e1>", "the", "kappaB", "enhancer", "and", "C1332802#ent", "<e2>", "response", "elements", "of", "many", "cytokine", "gene", "leading", "to", "cytokine", "production"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332802", "name": "C1332802#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "the", "efficacy", "of", "low-dose", "trofosfamide", "in", "combination", "with", "the", "peroxisome", "proliferator-activated", "receptor-gamma-agonist", "C0872972#ent", "<e1>", ",", "and", "the", "selective", "C0085387#ent", "<e2>", "rofecoxib", ",", "was", "evaluated", "in", "a", "pilot", "study"], "h": {"id": "C0872972", "name": "C0872972#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [20, 21]}}
{"token": ["Two", "of", "the", "4", "lines", "also", "showed", "homozygous", "deletions", "of", "C0809183#ent", "<e1>", ",", "while", "the", "remaining", "2", "lines", "retained", "both", "C0809183#ent", "<e1>", "C0002085#ent", "<e1>", "."], "h": {"id": "C0809183", "name": "C0809183#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [22, 23]}}
{"token": ["A", "patient", "with", "C0010691#ent", "<e1>", "who", "was", "treated", "with", "doses", "of", "C0030817#ent", "<e2>", "for", "19", "years", "developed", "skin", "abnormalities", "those", "seen", "in", "pseudoxanthoma", "elasticum"], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [11, 12]}}
{"token": ["Precipitation", "of", "endogenous", "cystine", "(", "2191", "micromol/L", ")", "from", "a", "C0010691#ent", "<e1>", "patient", "showed", "that", "DMSA", "and", "C0030817#ent", "<e2>", "were", "again", "highly", "effective", "compared", "to", "the", "other", "agents", "."], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [17, 18]}}
{"token": ["46", "pregnancies", "in", "patients", "with", "C0010691#ent", "<e1>", "treated", "with", "high", "fluid", "intake", "alone", "or", "in", "combination", "with", "C0030817#ent", "<e2>", "resulted", "in", "41", "normal", "births"], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [17, 18]}}
{"token": ["However", ",", "its", "role", "in", "chronic", "immune", "mediated", "C0442874#ent", "<e1>", "such", "as", "C0393847#ent", "<e2>", "MMN", ")", "or", "chronic", "inflammatory", "demyelinating", "polyradiculoneuropathy", "CIDP", ")", "is", "less", "clear", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0393847", "name": "C0393847#ent", "pos": [12, 13]}}
{"token": ["The", "relationship", "between", "these", "C0442874#ent", "<e1>", ",", "other", "variants", "of", "acute", "idiopathic", "polyneuritis", "C0393847#ent", "<e2>", "considered", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0393847", "name": "C0393847#ent", "pos": [13, 14]}}
{"token": ["Coexpression", "of", "dominant", "negative", "C0079068#ent", "<e1>", "or", "Max", "mutants", "C0812308#ent", "<e2>", "inhibited", "DNA", "synthesis", "indicating", "that", "functional", "C0079068#ent", "<e1>", "is", "necessary", "for", "induction", "of", "DNA", "synthesis", "C0812308#ent", "<e2>", "."], "h": {"id": "C0812308", "name": "C0812308#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [4, 5]}}
{"token": ["The", "C3537332#ent", "<e1>", "RPA", ")", "interacts", "with", "several", "human", "C1335608#ent", "<e2>", "DNA", "helicases", "have", "important", "roles", "in", "maintaining", "genomic", "stability", "however", ",", "the", "mechanism", "for", "RPA", "stimulation", "of", "DNA", "unwinding", "not", "well", "understood", "."], "h": {"id": "C3537332", "name": "C3537332#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335608", "name": "C1335608#ent", "pos": [9, 10]}}
{"token": ["Fourteen", "ultrasonically-guided", "percutaneous", "transcholecystic", "cholangiographies", "(", "PTCC", ")", "were", "performed", "in", "subjects", "with", "C0400979#ent", "<e1>", "different", "underlying", "C0012634#ent", "<e2>", "."], "h": {"id": "C0400979", "name": "C0400979#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [17, 18]}}
{"token": ["Increased", "lung", "uptake", "of", "thallium-201", "in", "exercise", "myocardial", "perfusion", "imaging", "a", "reliable", "marker", "of", "C3275121#ent", "<e1>", "patients", "with", "C0151744#ent", "<e2>"], "h": {"id": "C3275121", "name": "C3275121#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [18, 19]}}
{"token": ["Prompted", "by", "a", "case", "where", "a", "patient", "(", "with", "no", "risk", "factors", "and", "C3275121#ent", "<e1>", "developed", "angina", "pectoris", "previous", "blunt", "chest", "trauma", "we", "searched", "Medline", "for", "blunt", "chest", "trauma", "C0151744#ent", "<e2>"], "h": {"id": "C3275121", "name": "C3275121#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [29, 30]}}
{"token": ["C0860207#ent", "<e1>", "be", "considered", "in", "patients", "with", "C0038013#ent", "<e2>", "RA", ")", "who", "develop", "raised", "serum", "levels", "of", "liver", "enzymes", "taking", "sulphasalazine", "."], "h": {"id": "C0860207", "name": "C0860207#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}}
{"token": ["and", "C0028632#ent", "<e1>", ",", "sugar", "modifying", "C0014442#ent", "<e2>", ",", "and", "glycosyltransferases", "appear", "to", "be", "essential", "for", "their", "biosynthesis", "."], "h": {"id": "C0028632", "name": "C0028632#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}}
{"token": ["The", "identified", "sequences", "contained", "typical", "amino-terminal", "peptides", "mitochondrial", "protein", "import", "had", "characteristics", "of", "the", "C0028632#ent", "<e1>", "includes", "eukaryotic", "and", "eubacterial", "CCA-adding", "C0014442#ent", "<e2>", "."], "h": {"id": "C0028632", "name": "C0028632#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["This", "sequence", "is", "also", "conserved", "exclusively", "among", "the", "C0028632#ent", "<e1>", "even", "including", "mRNA-capping", "C0014442#ent", "<e2>", "with", "similar", "helical", "extensions", "at", "the", "C", "termini", "."], "h": {"id": "C0028632", "name": "C0028632#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "evaluate", "the", "efficacy", ",", "safety", "and", "tolerability", "of", "topical", "calcipotriol", "micrograms/g/ml", "solution", "vs.", "C0750848#ent", "<e1>", "the", "treatment", "of", "C0033860#ent", "<e2>", "of", "the", "scalp", "."], "h": {"id": "C0750848", "name": "C0750848#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [25, 26]}}
{"token": ["The", "rate", "of", "relapse", "after", "dithranol", "therapy", "is", "significantly", "less", "that", "when", "C0750848#ent", "<e1>", "occlusion", "is", "combined", "with", "ditrhanol", "in", "the", "treatment", "of", "C0033860#ent", "<e2>", "."], "h": {"id": "C0750848", "name": "C0750848#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [23, 24]}}
{"token": ["Calcipotriol", "cream", "monotherapy", "is", "more", "effective", "than", "placebo", ",", "and", "as", "effective", "as", "C0750848#ent", "<e1>", "coal", "tar", "in", "C0033860#ent", "<e2>", "."], "h": {"id": "C0750848", "name": "C0750848#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "rare", "case", "of", "C1849678#ent", "<e1>", "McKusick", "264470", ")", "presenting", "with", "dysmorphism", ",", "neurodevelopmental", "regression", "C0023520#ent", "<e2>", "."], "h": {"id": "C1849678", "name": "C1849678#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0023520", "name": "C0023520#ent", "pos": [17, 18]}}
{"token": ["A", "case", "of", "embryonal", "rhabdomyosarcoma", "the", "middle", "ear", "with", "C0376175#ent", "<e1>", "a", "polypoidal", "aural", "mass", "who", "subsequently", "had", "C4048158#ent", "<e2>", "due", "to", "intracranial", "extension", "presented", "for", "its", "rarity", "."], "h": {"id": "C0376175", "name": "C0376175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [18, 19]}}
{"token": ["Conditioned", "media", "concanavalin", "A", "Con", "A)-stimulated", "spleen", "cells", "and", "of", "purified", "protein", "derivative", "Bacillus", "Calmette-Gu\u00e9rin", "(BCG)-immune", "spleen", "cells", "contained", "the", "activities", "of", "C1366463#ent", "<e1>", ",", "MAF", "and", "C1415900#ent", "<e2>", "."], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [27, 28]}}
{"token": ["Achievements", "of", "comprehensive", "analysis", "been", "demonstrated", "in", "cases", "of", "some", "well-known", "C0029896#ent", "<e1>", ",", "the", "Prader-Willi", "syndrome", "Engelmann's", "syndrome", "the", "Martin-Bell", "syndrome", "C0026707#ent", "<e2>", "and", "retinoblastoma", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026707", "name": "C0026707#ent", "pos": [22, 23]}}
{"token": ["The", "use", "of", "intravenous", "C0033216#ent", "<e1>", "in", "the", "treatment", "of", "hyperpyrexia", "in", "a", "patient", "with", "C1840402#ent", "<e2>", "has", "not", "been", "previously", "reported", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [15, 16]}}
{"token": ["Adhesion", "was", "abolished", "in", "the", "presence", "of", "soluble", "ELC", ",", "C1332684#ent", "<e1>", "(", "CCR7", "ligands", ")", ",", "and", "TECK", "(", "a", "C1332673#ent", "<e2>", "ligand", ")", "."], "h": {"id": "C1332684", "name": "C1332684#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332673", "name": "C1332673#ent", "pos": [21, 22]}}
{"token": ["In", "whole", "blood", "cultures", "T", "cell", "proliferation", "multiple", "sclerosis", "C0026269#ent", "<e1>", ")", "patients", ",", "using", "soluble", "CD3", "mAb", "CD2", "mAb", "C0304402#ent", "<e2>", ",", "was", "reduced", "in", "comparison", "to", "healthy", "controls"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [20, 21]}}
{"token": ["Gain", "of", "function", "of", "SHP-2", ",", "a", "C0085536#ent", "<e1>", "positively", "modulates", "C0034678#ent", "<e2>", "signaling", ",", "is", "observed", "in", "nearly", "50", "%", "of", "affected", "individuals", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [11, 12]}}
{"token": ["Phosphatidylinositol", "3-kinase", "PI3K", "and", "both", "C0085536#ent", "<e1>", "SHP-1", "and", "SHP-2", ",", "are", "required", "upstream", "of", "C0034678#ent", "<e2>", "and", "Rap1", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [15, 16]}}
{"token": ["C0019154#ent", "<e1>", "with", "a", "wide", "range", "of", "severity", "and", "C2926735#ent", "<e2>", "of", "symptoms", "."], "h": {"id": "C0019154", "name": "C0019154#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [9, 10]}}
{"token": ["The", "development", "of", "therapeutic", "drugs", "C0004153#ent", "<e1>", "targeted", "specially", "against", "C1337092#ent", "<e2>", "may", "be", "useful", "in", "the", "prevention", "of", "plaque", "formation", "and", "future", "myocardial", "infarction"], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1337092", "name": "C1337092#ent", "pos": [10, 11]}}
{"token": ["Intriguingly", ",", "a", "major", "protein", "copurifying", "P450c17", "and", "C1706115#ent", "<e1>", "was", "identified", "as", "3beta-hydroxysteroid", "C0024544#ent", "<e2>", "(", "3beta-HSD", ")", "which", "was", "subsequently", "found", "not", "to", "directly", "bind", "Fld", "Sepharose", "."], "h": {"id": "C1706115", "name": "C1706115#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [14, 15]}}
{"token": ["P450c17", "and", "C1706115#ent", "<e1>", ",", "as", "well", "as", "3\u03b2-hydroxysteroid", "C0024544#ent", "<e2>", ",", "were", "not", "affected", "by", "surgery", "or", "estrogen", "."], "h": {"id": "C1706115", "name": "C1706115#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [9, 10]}}
{"token": ["The", "NAGLU", "activity", "restored", "by", "C0042769#ent", "<e1>", "sufficient", "to", "normalize", "C3536869#ent", "<e2>", "accumulation", ",", "which", "is", "directly", "responsible", "for", "the", "disease", "phenotype", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536869", "name": "C3536869#ent", "pos": [10, 11]}}
{"token": ["C1825027#ent", "<e1>", "GH", "and", "C1334089#ent", "<e2>", "in", "mammary", "epithelial", "cells", "suggested", "as", "one", "of", "the", "pathogenic", "mechanisms", "involved", "in", "the", "development", "of", "FMFH", "."], "h": {"id": "C1825027", "name": "C1825027#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [4, 5]}}
{"token": ["We", "conducted", "a", "phase", "2", "double-blind", ",", "placebo-controlled", "study", "evaluate", "the", "safety", "and", "C0003308#ent", "<e1>", "adjuvant", "recombinant", "interferon", "(rIFN)-", "gamma", "1b", "in", "patients", "with", "C0001175#ent", "<e2>", "acute", "cryptococcal", "meningitis"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [24, 25]}}
{"token": ["Stearoyl", "CoA", "synthetase", "C3710848#ent", "<e1>", "activities", "were", "present", "in", "microsomes", "and", "peroxisomes", ",", "but", "the", "activity", "of", "C0030238#ent", "<e2>", "several-fold", "greater", "compared", "to", "C3710848#ent", "<e1>", "both", "organelles", "."], "h": {"id": "C0030238", "name": "C0030238#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3710848", "name": "C3710848#ent", "pos": [3, 4]}}
{"token": ["In", "contrast", "to", "C0009324#ent", "<e1>", "Crohn's", "disease", "characterised", "by", "a", "diminished", "C0887942#ent", "<e2>", "expression", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0887942", "name": "C0887942#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", "to", "C0009324#ent", "<e1>", "Crohn's", "disease", "characterised", "by", "an", "impaired", "induction", "of", "human", "C0887942#ent", "<e2>", "3", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0887942", "name": "C0887942#ent", "pos": [14, 15]}}
{"token": ["Herein", "we", "describe", "a", "case", "of", "C0156272#ent", "<e1>", "a", "patient", "with", "Crohn's", "disease", "presented", "exclusively", "as", "C0426359#ent", "<e2>"], "h": {"id": "C0156272", "name": "C0156272#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0426359", "name": "C0426359#ent", "pos": [16, 17]}}
{"token": ["Protein", "solutions", "C0041236#ent", "<e1>", "were", "allowed", "to", "digest", "directly", "on", "the", "C0848332#ent", "<e2>", "of", "matrix-assisted", "laser", "desorption/ionization", "MALDI", ")", "plates", "under", "IR", "radiation"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0848332", "name": "C0848332#ent", "pos": [11, 12]}}
{"token": ["The", "histological", "pattern", "amyloid", "in", "the", "C0023899#ent", "<e1>", "could", "not", "predict", "the", "type", "of", "C0051783#ent", "<e2>", "was", "identified", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051783", "name": "C0051783#ent", "pos": [14, 15]}}
{"token": ["The", "possibility", "that", "C3273437#ent", "<e1>", "acts", "as", "a", "C1334960#ent", "<e2>", "within", "the", "central", "nervous", "system", "interacting", "with", "specific", "receptors", "would", "have", "to", "be", "considered", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334960", "name": "C1334960#ent", "pos": [8, 9]}}
{"token": ["The", "C0079427#ent", "<e1>", "merlin", "or", "C0085114#ent", "<e2>", ",", "inhibits", "cell", "growth", "motility", "as", "well", "as", "affects", "actin", "cytoskeleton-mediated", "processes", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085114", "name": "C0085114#ent", "pos": [5, 6]}}
{"token": ["These", "results", "provide", "a", "framework", "for", "understanding", "the", "C0079427#ent", "<e1>", "C0085114#ent", "<e2>", "and", "indicate", "that", "C0085114#ent", "<e2>", "mediates", "contact", "inhibition", "of", "growth", "by", "suppressing", "recruitment", "of", "Rac", "to", "matrix", "adhesions"], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085114", "name": "C0085114#ent", "pos": [10, 11]}}
{"token": ["A", "new", "strategy", "for", "the", "treatment", "of", "neuronal", "injury", "inhibition", "of", "the", "C1310550#ent", "<e1>", "GCP", "II", ",", "also", "known", "as", "C1333570#ent", "<e2>"], "h": {"id": "C1310550", "name": "C1310550#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [20, 21]}}
{"token": ["However", ",", "the", "patients", "with", "C0042166#ent", "<e1>", "had", "higher", "levels", "of", "IgA", "class", "antibodies", "to", "C2697656#ent", "<e2>", "of", "K.", "pneumoniae", "E.", "coli", "compared", "to", "the", "patients", "without", "C0042166#ent", "<e1>", "."], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [15, 16]}}
{"token": ["One", "hundred", "cases", "of", "C0578870#ent", "<e1>", "CIU", ")", "were", "studied", "to", "determine", "the", "incidence", "of", "C2973529#ent", "<e2>", "LV", ")", "and", "the", "clinical", "and", "laboratory", "data", "that", "might", "indicate", "its", "presence", "."], "h": {"id": "C0578870", "name": "C0578870#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2973529", "name": "C2973529#ent", "pos": [15, 16]}}
{"token": ["It", "essentially", "depends", "on", "the", "nutritional", "status", "folic", "acid", "C3469521#ent", "<e1>", ")", "and", "vitamins", "B12", "B6", ",", "but", "also", "on", "the", "C0066357#ent", "<e2>", "MTHFR", ")", "enzymatic", "activity"], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0066357", "name": "C0066357#ent", "pos": [21, 22]}}
{"token": ["Using", "forty-three", "patients", "with", "C0006863#ent", "<e1>", "and", "fifty-seven", "autopsy", "cases", "in", "which", "history", "of", "C0016977#ent", "<e2>", "not", "demonstrated", ",", "histopathological", "studies", "been", "performed", "."], "h": {"id": "C0006863", "name": "C0006863#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016977", "name": "C0016977#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "either", "test", "on", "its", "own", "may", "be", "misleading", "in", "differentiating", "C0271725#ent", "<e1>", "other", "causes", "of", "the", "C1848862#ent", "<e2>", "."], "h": {"id": "C0271725", "name": "C0271725#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [18, 19]}}
{"token": ["The", "apoptotic", "effect", "caspase-dependent", "since", "C1332668#ent", "<e1>", "3", "are", "activated", "and", "the", "caspase", "inhibitor", "benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone", "(", "C0383779#ent", "<e2>", ")", "blocks", "apoptosis", "."], "h": {"id": "C1332668", "name": "C1332668#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0383779", "name": "C0383779#ent", "pos": [16, 17]}}
{"token": ["We", "consider", "that", "it", "is", "important", "to", "analyze", "these", "C1858361#ent", "<e1>", "for", "the", "investigation", "of", "pathogenesis", "of", "C0004364#ent", "<e2>"], "h": {"id": "C1858361", "name": "C1858361#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [17, 18]}}
{"token": ["A", "58", "year", "old", "man", "in", "C0038218#ent", "<e1>", "to", "drug", "therapy", "was", "relieved", "by", "long-term", "C0022180#ent", "<e2>", "inhalation", "."], "h": {"id": "C0038218", "name": "C0038218#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [15, 16]}}
{"token": ["C3889658#ent", "<e1>", "RNA", "was", "C0907533#ent", "<e2>", "expressed", "at", "low", "levels", "in", "log", "phase", "cells", "while", "ABC2", "RNA", "undetectable", "."], "h": {"id": "C3889658", "name": "C3889658#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [4, 5]}}
{"token": ["We", "assessed", "the", "role", "of", "endothelin-1", "(", "C3273436#ent", "<e1>", ")", "in", "the", "development", "of", "anterior", "chamber", "inflammation", "pigmented", "rabbit", "C0235267#ent", "<e2>", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [19, 20]}}
{"token": ["We", "then", "studied", "the", "effects", "of", "C3273436#ent", "<e1>", "on", "rabbit", "C0235267#ent", "<e2>", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "exercise", "tolerance", "test", "supine", "multistage", "bicycle", "ergometer", "test", "performed", "and", "C0004099#ent", "<e1>", "hemodynamic", "alteration", "was", "evaluated", "in", "18", "patients", "with", "C0151744#ent", "<e2>", "16", "males", "and", "2", "females", ",", "average", "age", "56.3", "years", ")", "."], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [24, 25]}}
{"token": ["C3536715#ent", "<e1>", "the", "bladder", "is", "a", "rare", "C0029896#ent", "<e2>", "approximately", "20", "cases", "published", ")", "."], "h": {"id": "C3536715", "name": "C3536715#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [7, 8]}}
{"token": ["Examination", "of", "the", "tryptic", "peptide", "of", "32P-labeled", "P110", "and", "C2348445#ent", "<e1>", "suggested", "that", "the", "additional", "C0085536#ent", "<e2>", "in", "P110", "resulted", "from", "phosphorylation", "at", "discrete", "sites", "within", "the", "protein", "."], "h": {"id": "C2348445", "name": "C2348445#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [15, 16]}}
{"token": ["Less", "common", "C0012634#ent", "<e1>", "of", "the", "feline", "liver", "include", "extrahepatic", "biliary", "obstruction", "portacaval", "vascular", "anomalies", "hepatic", "parasites", "C0267834#ent", "<e2>", "and", "diaphragmatic", "hernia"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0267834", "name": "C0267834#ent", "pos": [17, 18]}}
{"token": ["Since", "C0003873#ent", "<e1>", "fell", "more", "than", "C1418479#ent", "<e2>", ",", "a", "slight", "but", "significant", "decrease", "of", "plasma", "glucose", "concentration", "occurred", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418479", "name": "C1418479#ent", "pos": [6, 7]}}
{"token": ["At", "rest", ",", "trained", "MPA-treated", "rats", "had", "lower", "blood", "glucose", "higher", "blood", "lactate", "and", "similar", "glucose", "C0003873#ent", "<e1>", "and", "disappearance", "rates", "(", "C1418479#ent", "<e2>", ")", "than", "trained", "sham-injected", "animals", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418479", "name": "C1418479#ent", "pos": [22, 23]}}
{"token": ["Phenytoin", "and", "other", "C0003286#ent", "<e1>", "such", "as", "phenobarbital", "and", "carbamazepine", "induce", "C0010762#ent", "<e2>", "produce", "oxidative", "reactive", "intermediates", "that", "may", "be", "implicated", "in", "hypersensitivity", "reactions", "as", "EMM", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [11, 12]}}
{"token": ["The", "central", "enzymatic", "steps", "of", "peroxisomal", "beta-oxidation", "performed", "by", "C0050690#ent", "<e1>", "ACOX", ")", ",", "the", "C0536221#ent", "<e2>", "MFP", ")", "and", "3-ketoacyl-CoA", "thiolase", "thiolase", ")", "."], "h": {"id": "C0050690", "name": "C0050690#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [15, 16]}}
{"token": ["Following", "the", "formation", "of", "the", "CoA-ester", ",", "the", "machinery", "for", "the", "degradation", "of", "endogenous", "fatty", "acids", "of", "C0050690#ent", "<e1>", "D-3-hydroxyacyl-CoA", "hydrolyase", "2,3-enoyl-CoA", "isomerase", "isoenzymes", "of", "the", "C0536221#ent", "<e2>", "thiolase", "."], "h": {"id": "C0050690", "name": "C0050690#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [26, 27]}}
{"token": ["C0070166#ent", "<e1>", "reduced", "collagen-induced", "platelet", "aggregation", "in", "non-carriers", "of", "the", "C0002085#ent", "<e2>", "P", "=", "0.03", ")", ",", "which", "resulted", "in", "an", "increase", "in", "C0002085#ent", "<e2>", "carriers", "during", "the", "overall", "study", "P", "=", "0.04", ")", "."], "h": {"id": "C0070166", "name": "C0070166#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [10, 11]}}
{"token": ["To", "examine", "the", "species", "barriers", "between", "C1334982#ent", "<e1>", "primates", "and", "humans", ",", "we", "sequenced", "the", "open", "reading", "frames", "C0013570#ent", "<e2>", ")", "of", "25", "PrP", "genes", "from", "apes", "and", "monkeys", "."], "h": {"id": "C1334982", "name": "C1334982#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [18, 19]}}
{"token": ["Factor", "VIII", "C1704822#ent", "<e1>", ")", "inhibitors", "appear", "in", "3", "-", "20", "%", "of", "C0019069#ent", "<e2>", "A", "patients", "after", "injection", "of", "C1704822#ent", "<e1>", "concentrates", "."], "h": {"id": "C1704822", "name": "C1704822#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [13, 14]}}
{"token": ["C1333356#ent", "<e1>", "A", "or", "C1333356#ent", "<e1>", "G", "had", "an", "additive", "effect", "used", "with", "standard", "C0729502#ent", "<e1>"], "h": {"id": "C1333356", "name": "C1333356#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [14, 15]}}
{"token": ["The", "1994", "-", "97", "C0771711#ent", "<e1>", "survival", "rates", "all", "categories", "were", "higher", "than", "in", "previous", "C1415714#ent", "<e2>", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415714", "name": "C1415714#ent", "pos": [15, 16]}}
{"token": ["The", "1994", "-", "97", "C0771711#ent", "<e1>", "survival", "rates", "all", "categories", "were", "significantly", "higher", "than", "in", "previous", "C1415714#ent", "<e2>", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415714", "name": "C1415714#ent", "pos": [16, 17]}}
{"token": ["C1956346#ent", "<e1>", "myocardial", "infarction", "risk", "reduction", "in", "elderly", "patients", "by", "C0085542#ent", "<e2>", "in", "the", "PROSPER", "study", "was", "similar", "to", "the", "benefit", "of", "statins", "in", "middle-aged", "populations", "in", "other", "studies", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0085542", "name": "C0085542#ent", "pos": [10, 11]}}
{"token": ["The", "C1305923#ent", "<e1>", "from", "these", "recombinant", "C0011519#ent", "<e2>", "in", "vitro", "be", "efficiently", "imported", "into", "isolated", "spinach", "chloroplasts", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [6, 7]}}
{"token": ["Within", "intron", "1", "is", "an", "open", "reading", "frame", "the", "potential", "to", "encode", "a", "323", "C1305923#ent", "<e1>", "contained", "dodecapeptide", "sequences", "typical", "of", "RNA", "maturases", "and", "C0011519#ent", "<e2>"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [24, 25]}}
{"token": ["Acute", "(", "suppurative", ")", "C0040147#ent", "<e1>", "is", "a", "rare", ",", "C0040150#ent", "<e2>", "by", "bacteria", "and", "other", "microbes", "."], "h": {"id": "C0040147", "name": "C0040147#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0040150", "name": "C0040150#ent", "pos": [10, 11]}}
{"token": ["Dimethyloxallyl", "glycine", "a", "stabilizer", "of", "hypoxia-inducible", "factor", "1alpha", "HIF1alpha", ")", ",", "mimicked", "the", "hypoxia-mediated", "upregulation", "of", "C1571622#ent", "<e1>", ",", "and", "YC1", ",", "an", "inhibitor", "of", "C1333897#ent", "<e2>", "cancelled", "the", "hypoxia-induced", "upregulation", "of", "C1571622#ent", "<e1>", "mRNA", "."], "h": {"id": "C1333897", "name": "C1333897#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1571622", "name": "C1571622#ent", "pos": [16, 17]}}
{"token": ["C1704793#ent", "<e1>", "led", "to", "a", "rise", "in", "plasma", "concentrations", "of", "both", "C1419788#ent", "<e2>", "and", "cortisol", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419788", "name": "C1419788#ent", "pos": [11, 12]}}
{"token": ["The", "peculiar", "pharmacological", "profile", "each", "compound", "may", "help", "to", "explain", "the", "different", "impact", "of", "each", "C3536840#ent", "<e1>", "on", "the", "inflammatory", "process", "on", "C0021390#ent", "<e2>", "."], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [22, 23]}}
{"token": ["Monocytes", "obtained", "from", "patients", "receiving", "the", "lymphokine", "demonstrated", "an", "increased", "respiratory", "burst", "a", "2.5", "-", "5.1-fold", "increase", "in", "tumor", "necrosis", "factor", "alpha", "C1710304#ent", "<e1>", ")", "secretion", "in", "response", "to", "C2987634#ent", "<e2>", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [29, 30]}}
{"token": ["Thus", "it", "is", "evident", "that", "endothelial", "cells", "release", "NO", "for", "a", "prolonged", "period", "in", "response", "to", "C1710304#ent", "<e1>", "and", "transiently", "when", "stimulated", "with", "C2987634#ent", "<e2>"], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [23, 24]}}
{"token": ["The", "expression", "profiles", "three", "enzymes", "that", "convert", "naringenin", "to", "the", "C0022179#ent", "<e1>", ",", "genistein", ",", "chalcone", "isomerase", "CHI", ")", ",", "C0083064#ent", "<e2>", "IFS", ")", "and", "flavanone", "3-hydroxylase", "F3H", ")", "were", "examined", "."], "h": {"id": "C0022179", "name": "C0022179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0083064", "name": "C0083064#ent", "pos": [20, 21]}}
{"token": ["Reconstituted", "translocation", "required", "C1705556#ent", "<e1>", ",", "and", "was", "deficient", "when", "sec63", "and", "C1417826#ent", "<e2>", "(", "BiP", ")", "mutant", "cells", "used", "as", "a", "source", "of", "membranes", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417826", "name": "C1417826#ent", "pos": [12, 13]}}
{"token": ["Within", "the", "C1420192#ent", "<e1>", "interactions", "are", "with", "the", "first", "C1364818#ent", "<e2>", "repeat", ",", "a", "site", "strongly", "implicated", "in", "motor", "function", "and", "the", "NH2-terminal", "cargo-binding", "region", "."], "h": {"id": "C1420192", "name": "C1420192#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [9, 10]}}
{"token": ["Isoproterenol", "(", "ISO", ")", ",", "a", "C0001644#ent", "<e1>", "enhanced", "the", "intracellular", "fluorescence", "intensity", "both", "C0121300#ent", "<e2>", "and", "protoporphyrin", "IX", "PpIX", ")", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0121300", "name": "C0121300#ent", "pos": [14, 15]}}
{"token": ["Two", "neonates", "with", "clinical", "features", "of", "meconium", "plug", "syndrome", "C0026705#ent", "<e1>", ")", "were", "found", "to", "have", "C0267548#ent", "<e2>", "associated", "with", "meconium", "plugs", "in", "the", "distal", "ileum"], "h": {"id": "C0026705", "name": "C0026705#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0267548", "name": "C0267548#ent", "pos": [16, 17]}}
{"token": ["Their", "livers", "were", "investigated", "histologically", "and", "histochemically", "for", "glycogen", ",", "RNA", ",", "fat", ",", "alkaline", "and", "acid", "phosphatases", "adenosine", "triphosphatase", "5'-nucleotidase", ",", "glucose-6-phosphatase", ",", "glucose-6-phosphate", "dehydrogenase", "C0038615#ent", "<e1>", "and", "alkaline", "and", "C0597094#ent", "<e2>"], "h": {"id": "C0038615", "name": "C0038615#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0597094", "name": "C0597094#ent", "pos": [31, 32]}}
{"token": ["C0043366#ent", "<e1>", "increased", "intra-uterine", "pressure", "49", "mmHg", "and", "had", "a", "C2926735#ent", "<e2>", "of", "action", "of", "8", "min", "."], "h": {"id": "C0043366", "name": "C0043366#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [10, 11]}}
{"token": ["C0043366#ent", "<e1>", "a", "significantly", "greater", "C2926735#ent", "<e2>", "of", "analgesia", ",", "as", "measured", "by", "this", "model", ",", "than", "did", "epidural", "lidocaine"], "h": {"id": "C0043366", "name": "C0043366#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [5, 6]}}
{"token": ["To", "evaluate", "levels", "of", "C-reactive", "protein", "CRP", ")", "during", "C0015967#ent", "<e1>", "episodes", "in", "children", "with", "C0015974#ent", "<e2>", "aphthous", "stomatitis", "pharyngitis", "and", "cervical", "adenitis", "syndrome", "PFAPA", ")", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015974", "name": "C0015974#ent", "pos": [15, 16]}}
{"token": ["C0041296#ent", "<e1>", "and", "leprosy", ",", "both", "are", "tissue-", "C0003838#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003838", "name": "C0003838#ent", "pos": [8, 9]}}
{"token": ["This", "suggests", "that", "ability", "of", "v-raf", "to", "suppress", "apoptosis", "in", "the", "absence", "of", "ligand", "is", "either", "C1704467#ent", "<e1>", "independent", "or", "that", "C0949794#ent", "<e2>", "Bcl-2", "function", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0949794", "name": "C0949794#ent", "pos": [21, 22]}}
{"token": ["Apoptotic", "cells", "in", "bile", "ducts", "surrounding", "C0669372#ent", "<e1>", "after", "partial", "hepatectomy", "in", "the", "C1718895#ent", "<e2>", "group", ",", "although", "apoptotic", "cells", "rare", "in", "the", "control", "group"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1718895", "name": "C1718895#ent", "pos": [13, 14]}}
{"token": ["The", "kinetics", "of", "CPM", "uptake", "by", "C0669372#ent", "<e1>", "isolated", "from", "normal", "rats", "and", "rats", "with", "C1718895#ent", "<e2>", "could", "be", "explained", "by", "the", "combination", "of", "saturable", "carrier-mediated", "and", "nonsaturable", "first-order", "rate", "processes", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1718895", "name": "C1718895#ent", "pos": [15, 16]}}
{"token": ["Cytosols", "from", "various", "tissues", ",", "C0023837#ent", "<e1>", "protein", "kinase", "C", "purified", "from", "chicken", "stomach", ",", "did", "not", "substitute", "C1417609#ent", "<e2>"], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417609", "name": "C1417609#ent", "pos": [18, 19]}}
{"token": ["First", "Hydrochlorothiazide", "(", "HCTZ", ")", "and", "then", ",", "if", "necessary", ",", "C0030040#ent", "<e1>", "(", "OXP", ")", "and", "C0012271#ent", "<e2>", "(", "DIH", ")", "."], "h": {"id": "C0030040", "name": "C0030040#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012271", "name": "C0012271#ent", "pos": [17, 18]}}
{"token": ["Treatment", "with", "a", "synthetic", "MMP", "inhibitor", "GM6001", ",", "in", "utero", "enhanced", "the", "branching", "pattern", "in", "both", "C1883559#ent", "<e1>", "null", "lungs", "by", "a", "restoration", "of", "fibronectin", "localization", "signaling", "through", "C1704657#ent", "<e2>", "and", "epithelial", "cell", "proliferation", "null", "lungs"], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704657", "name": "C1704657#ent", "pos": [28, 29]}}
{"token": ["This", "clearly", "resolved", "electrophoretic", "banding", "pattern", "of", "C3853627#ent", "<e1>", "from", "pure", "C0949854#ent", "<e2>", "demonstrated", "for", "variant", "human", "C3853627#ent", "<e1>", "as", "well", "."], "h": {"id": "C3853627", "name": "C3853627#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0949854", "name": "C0949854#ent", "pos": [11, 12]}}
{"token": ["The", "usual", "C0029166#ent", "<e1>", "ADM", "and", "C0796074#ent", "<e2>", "were", "observed", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [6, 7]}}
{"token": ["To", "test", "another", "macromolecule", ",", "we", "now", "compare", "C1415375#ent", "<e1>", "and", "betaine", "in", "counteracting", "reduction", "of", "the", "thermal", "stability", "C0035542#ent", "<e2>", "urea", "."], "h": {"id": "C1415375", "name": "C1415375#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [19, 20]}}
{"token": ["Phosphate", "is", "a", "competitive", "inhibitor", "of", "transesterification", "of", "C1415375#ent", "<e1>", "by", "the", "C0035542#ent", "<e2>"], "h": {"id": "C1415375", "name": "C1415375#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [12, 13]}}
{"token": ["To", "investigate", "the", "effect", "of", "C0010592#ent", "<e1>", "on", "cytokine", "production", "especially", "on", "T", "helper", "1", "C3540579#ent", "<e2>", ")", "and", "T", "helper", "2", "Th2", ")", "type", "cytokines", ",", "in", "patients", "with", "rheumatoid", "arthritis", "RA", ")", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [15, 16]}}
{"token": ["C0010592#ent", "<e1>", "in", "contrast", ",", "inhibited", "both", "C3540579#ent", "<e2>", "and", "Th2", "cytokine", "production", "by", "PHA-stimulated", "PBMC", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [7, 8]}}
{"token": ["Cervical", "MRI", "spinal", "cord", "at", "the", "C4/5", "and", "C5/6", "levels", "due", "to", "C0038019#ent", "<e1>", "prominent", "edema", "in", "the", "spinal", "cord", "from", "the", "C4", "to", "C1413014#ent", "<e2>", "level", "."], "h": {"id": "C0038019", "name": "C0038019#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413014", "name": "C1413014#ent", "pos": [24, 25]}}
{"token": ["Here", ",", "we", "show", "that", "induced", "C0268576#ent", "<e1>", "by", "leptin", "infusion", "C2712370#ent", "<e2>", "insulin", "signalling", "rat", "liver", "."], "h": {"id": "C0268576", "name": "C0268576#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [11, 12]}}
{"token": ["Several", "C2987634#ent", "<e1>", "induced", "both", "WDS", "and", "C0004134#ent", "<e2>", ",", "but", "C0004134#ent", "<e2>", "was", "not", "blocked", "by", "serotonergic", "drugs"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [7, 8]}}
{"token": ["SB", "215520", ",", "SB", "215519", "and", "niravoline", "are", "selective", "C2987634#ent", "<e1>", "variable", "abilities", "to", "cause", "a", "water", "diuresis", "C0004134#ent", "<e2>", "in", "rats", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [18, 19]}}
{"token": ["The", "ratio", "of", "C3539699#ent", "<e1>", "+", "lymphocytes", "to", "C0206744#ent", "<e2>", "reflect", "the", "fraction", "of", "infected", "C0206744#ent", "<e2>"], "h": {"id": "C3539699", "name": "C3539699#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0206744", "name": "C0206744#ent", "pos": [8, 9]}}
{"token": ["Phase", "3", "studies", "C1142738#ent", "<e1>", "for", "the", "treatment", "of", "invasive", "candidiasis", "C0877445#ent", "<e2>", "are", "warranted", "."], "h": {"id": "C1142738", "name": "C1142738#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0877445", "name": "C0877445#ent", "pos": [11, 12]}}
{"token": ["VEGF", "and", "C1333897#ent", "<e1>", "levels", "were", "blocked", "by", "inhibitors", "of", "C2936824#ent", "<e2>", "mammalian", "target", "of", "rapamycin", "."], "h": {"id": "C1333897", "name": "C1333897#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "variety", "of", "C0035064#ent", "<e1>", "on", "the", "mouse", "antibody", "response", "to", "sheep", "red", "cells", "C3853644#ent", "<e2>", ")", "and", "Escherichia", "coli", "lipopolysaccharide", "LPS", ")", "were", "investigated", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [16, 17]}}
{"token": ["C2936882#ent", "<e1>", "markedly", "decreased", "the", "amounts", "of", "fat", "accumulation", "and", "C1416902#ent", "<e2>", "LPL", ")", "mRNA", "as", "well", "as", "triglyceride", "accumulation", "in", "genetically", "manipulated", "3T3-L1", "adipocytes", "stably", "expressing", "the", "estrogen", "receptor", "ER", ")", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [10, 11]}}
{"token": ["The", "results", "indicate", "that", "C0027375#ent", "<e1>", "is", "initially", "converted", "to", "cis-", "and", "trans-1,2-dihydroxy-1,2-dihydronaphthalene", "by", "C0599874#ent", "<e2>", "and", "monooxygenase", "catalyzed", "reactions", ",", "respectively", "."], "h": {"id": "C0027375", "name": "C0027375#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599874", "name": "C0599874#ent", "pos": [14, 15]}}
{"token": ["The", "use", "of", "bioengineered", "human", "corneal", "constructs", "containing", "GDNF-transduced", "epithelial", "cells", "represents", "a", "novel", "method", "for", "delivering", "of", "this", "C0079429#ent", "<e1>", "to", "promote", "survival", "of", "transplanted", "corneal", "epithelium", "treat", "various", "C0010034#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010034", "name": "C0010034#ent", "pos": [30, 31]}}
{"token": ["Similarly", ",", "mice", "with", "a", "disrupted", "IL-10", "C0079429#ent", "<e1>", "developed", "more", "severe", "C0010034#ent", "<e2>", "wild-type", "controls", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010034", "name": "C0010034#ent", "pos": [12, 13]}}
{"token": ["KRX-725", "mimics", "the", "effects", "of", "sphingosine", "1-phosphate", "S1P", ")", ",", "the", "natural", "ligand", "C1414255#ent", "<e1>", ",", "by", "triggering", "a", "Gi-dependent", "MEK-ERK", "(", "C0169101#ent", "<e2>", "extracellular", "signal-regulated", "kinase", "signal", "transduction", "pathway"], "h": {"id": "C1414255", "name": "C1414255#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [22, 23]}}
{"token": ["The", "main", "mechanism", "proposed", "to", "explain", "this", "condition", "is", "the", "unmasking", "of", "C0265338#ent", "<e1>", "after", "the", "C3537183#ent", "<e2>", "allowed", "corticosteroid", "tapering", "."], "h": {"id": "C0265338", "name": "C0265338#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3537183", "name": "C3537183#ent", "pos": [16, 17]}}
{"token": ["The", "detection", "and", "description", "of", "the", "functional", "activity", "of", "anti", "S.", "mansoni", "antibodies", "and", "the", "relationship", "between", "five", "different", "C0018100#ent", "<e1>", "each", "corresponding", "to", "one", "immunological", "test", "C0036323#ent", "<e2>", ",", "are", "described", "."], "h": {"id": "C0018100", "name": "C0018100#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [27, 28]}}
{"token": ["This", "article", "reviews", "the", "wide", "range", "of", "immunoassays", "and", "C0018100#ent", "<e1>", "have", "been", "shown", "to", "have", "potential", "for", "diagnosis", "of", "C0036323#ent", "<e2>", "by", "the", "indirect", "method", "of", "antibody", "detection", "."], "h": {"id": "C0018100", "name": "C0018100#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [20, 21]}}
{"token": ["The", "reproducible", "induction", "of", "protective", "immunity", "attenuated", "parasites", "and", "with", "C0018100#ent", "<e1>", "now", "led", "to", "agreement", "that", "vaccination", "against", "C0036323#ent", "<e2>", "is", "on", "achievable", "goal", "."], "h": {"id": "C0018100", "name": "C0018100#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [19, 20]}}
{"token": ["PS-PLA1", ",", "mPA-PLA1alpha", "and", "mPA-PLA1beta", "exhibit", "only", "C0031666#ent", "<e1>", "activity", ",", "while", "HL", ",", "C1823249#ent", "<e2>", "and", "PLRP2", "show", "triacylglycerol-hydrolyzing", "activity", "addition", "to", "C0031666#ent", "<e1>", "activity", "."], "h": {"id": "C1823249", "name": "C1823249#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031666", "name": "C0031666#ent", "pos": [7, 8]}}
{"token": ["First", ",", "lipase", "members", "PLA1", "activity", "(", "PS-PLA1", ",", "mPA-PLA1alpha", "and", "mPA-PLA1beta", ",", "C1823249#ent", "<e1>", ",", "guinea", "pig", "PLRP2", "and", "C0031666#ent", "<e2>", "from", "hornet", "venom", "DolmI", ")", ")", "have", "short", "lids"], "h": {"id": "C1823249", "name": "C1823249#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031666", "name": "C0031666#ent", "pos": [20, 21]}}
{"token": ["Depression", "found", "in", "C1868675#ent", "<e1>", "PD", ")", "usually", "responds", "to", "selective", "serotonin", "reuptake", "inhibitors", "C1579361#ent", "<e2>", ")", "."], "h": {"id": "C1868675", "name": "C1868675#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1579361", "name": "C1579361#ent", "pos": [14, 15]}}
{"token": ["Bovine", "MAP2", "kinase", ",", "Cdc2", "kinase", "mitogenic", "activated", "protein", "kinase", "and", "the", "C0172973#ent", "<e1>", "able", "to", "phosphorylate", "C1424480#ent", "<e2>", "but", "do", "not", "change", "the", "affinity", "for", "microtubules", "."], "h": {"id": "C0172973", "name": "C0172973#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1424480", "name": "C1424480#ent", "pos": [17, 18]}}
{"token": ["The", "mRNA", "levels", "for", "the", "small", "subunit", "ribonucleotide", "reductase", "C1419437#ent", "<e1>", ")", "and", "sensitivity", "to", "C0020402#ent", "<e2>", "and", "MAIQ", "were", "determined", "in", "four", "strains", "of", "the", "yeast", ",", "Saccharomyces", "cerevisiae"], "h": {"id": "C1419437", "name": "C1419437#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [15, 16]}}
{"token": ["In", "both", "C0019655#ent", "<e1>", "and", "aspergillosis", ",", "C0064113#ent", "<e2>", "has", "produced", "impressive", "therapeutic", "results", "and", "in", "C0019655#ent", "<e1>", ",", "secondary", "prophylaxis", "well", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [2, 3]}}
{"token": ["C0064113#ent", "<e1>", "significantly", "delayed", "time", "to", "onset", "of", "C0019655#ent", "<e2>", "(", "P", "=", ".03", ";", "log-rank", "test", ")", "and", "cryptococcosis", "(", "P", "=", ".0005", ";", "log-rank", "test", ")", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [8, 9]}}
{"token": ["To", "perform", "a", "meta-analysis", "comparing", "the", "efficacy", "and", "safety", "of", "recommended", "dosages", "of", "nonsteroidal", "antiinflammatory", "drugs", "NSAIDs", ")", ",", "including", "cyclooxygenase", "2", "inhibitors", "versus", "C0000970#ent", "<e1>", "in", "the", "treatment", "of", "symptomatic", "C1335638#ent", "<e2>", "and", "knee", "osteoarthritis"], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1335638", "name": "C1335638#ent", "pos": [31, 32]}}
{"token": ["Activation", "of", "C1822686#ent", "<e1>", "via", "the", "C3658210#ent", "<e2>", "dimethyloxalylglycine", "attenuated", "hemin-induced", "IL-8", "secretion", "."], "h": {"id": "C1822686", "name": "C1822686#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3658210", "name": "C3658210#ent", "pos": [6, 7]}}
{"token": ["Patients", "with", "C0010674#ent", "<e1>", "a", "high", "incidence", "of", "C0008350#ent", "<e2>", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008350", "name": "C0008350#ent", "pos": [8, 9]}}
{"token": ["The", "induced", "genes", "can", "be", "classified", "mainly", "as", "cell", "cycle", "inhibitors", "p21waf", ",", "GADD45", ",", "C1419987#ent", "<e1>", "Fas/APO1", "and", "PIG3", "or", "C1333237#ent", "<e2>", "DDB2", ",", "DNA", "ligase", "G/T", "mismatch", "DNA", "glycosylase"], "h": {"id": "C1419987", "name": "C1419987#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [21, 22]}}
{"token": ["The", "\u03b2-adrenergic", "receptors", "are", "regulated", "by", "a", "set", "of", "specific", "C0031727#ent", "<e1>", ",", "termed", "the", "C0872043#ent", "<e2>", "GRKs", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0872043", "name": "C0872043#ent", "pos": [15, 16]}}
{"token": ["However", ",", "such", "phosphorylation", "was", "mediated", "by", "the", "type", "II", "TGF-beta", "receptor", "TbetaRII", ")", ",", "which", "is", "itself", "a", "C0031727#ent", "<e1>", ",", "rather", "than", "by", "a", "C0872043#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0872043", "name": "C0872043#ent", "pos": [26, 27]}}
{"token": ["Eighty-six", "cases", "with", "C0042594#ent", "<e1>", "11", "cases", "with", "C0042568#ent", "<e2>", "and", "26", "cases", "with", "autonomic", "nerve", "disorders", "recognized", "."], "h": {"id": "C0042594", "name": "C0042594#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042568", "name": "C0042568#ent", "pos": [8, 9]}}
{"token": ["The", "aim", "of", "our", "investigation", "was", "to", "analyze", "the", "results", "of", "caloric", "and", "electronystagmographic", "investigation", "of", "C0042594#ent", "<e1>", "patients", "with", "C0042568#ent", "<e2>"], "h": {"id": "C0042594", "name": "C0042594#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042568", "name": "C0042568#ent", "pos": [20, 21]}}
{"token": ["Since", "thallium", "binds", "sulfhydryl", "groups", "the", "use", "of", "C0001047#ent", "<e1>", "is", "also", "considered", "as", "a", "potential", "C0003295#ent", "<e2>", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [8, 9]}, "relation": "has_therapeutic_class", "t": {"id": "C0003295", "name": "C0003295#ent", "pos": [16, 17]}}
{"token": ["Secretory", "leukocyte", "protease", "inhibitor", "SLPI", ")", "is", "a", "C3536890#ent", "<e1>", "the", "whey", "acidic", "protein-like", "family", "inhibiting", "C0055673#ent", "<e2>", ",", "chymotrypsin", ",", "elastase", ",", "proteinase", "3", "cathepsin", "G", "tryptase", "."], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [16, 17]}}
{"token": ["Competition", "experiments", "that", "estrone", ",", "estriol", ",", "and", "progesterone", "had", "25", "%", "of", "the", "affinity", "of", "estradiol", ",", "whereas", "C0985528#ent", "<e1>", ",", "androgens", ",", "and", "C3540725#ent", "<e2>", "had", "low", "affinity", "."], "h": {"id": "C0985528", "name": "C0985528#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [25, 26]}}
{"token": ["The", "prodrug", "approach", "is", "illustrated", "by", "discussion", "of", "the", "esterification", "of", "epinephrine", "and", "the", "production", "of", "the", "C0012274#ent", "<e1>", "form", "of", "C0071808#ent", "<e2>", "(", "pro-2-PAM", ")", "."], "h": {"id": "C0012274", "name": "C0012274#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0071808", "name": "C0071808#ent", "pos": [21, 22]}}
{"token": ["Although", "GH", "is", "also", "known", "to", "exert", "the", "trophic", "effect", "the", "C0021831#ent", "<e1>", "its", "role", "in", "the", "healing", "of", "C0151971#ent", "<e2>", "not", "known", "."], "h": {"id": "C0021831", "name": "C0021831#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0151971", "name": "C0151971#ent", "pos": [19, 20]}}
{"token": ["The", "different", "expression", "of", "HSP-60", ",", "Ciclin", "D1", ",", "jun", "proto-oncogene", "C0012920#ent", "<e1>", "that", "these", "C1417679#ent", "<e2>", "may", "play", "a", "role", "in", "ACC", "pathogenesis", "and", "could", "represent", "potential", "diagnostic/prognostic/therapeutic", "target", "markers", "."], "h": {"id": "C0012920", "name": "C0012920#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["This", "promoter", "is", "activated", "by", "mutations", "in", "the", "gene", "encoding", "C0012920#ent", "<e1>", "but", "is", "apparently", "unaffected", "by", "mutations", "in", "the", "C1417679#ent", "<e2>", "encoding", "DNA", "gyrase"], "h": {"id": "C0012920", "name": "C0012920#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["C0007075#ent", "<e1>", "only", "slightly", "inhibited", "by", "C0037506#ent", "<e2>", "."], "h": {"id": "C0007075", "name": "C0007075#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [6, 7]}}
{"token": ["C0027765#ent", "<e1>", "as", "Gayet-Wernicke", "encephalopathy", "to", "thiamine", "deficiency", "or", "C0031117#ent", "<e2>", "also", "be", "observed", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [9, 10]}}
{"token": ["C0907533#ent", "<e1>", "Wg", "signaling", "SSCs", "through", "the", "removal", "of", "its", "negative", "regulators", "C1332125#ent", "<e2>", "and", "shaggy", ",", "also", "causes", "SSC", "loss"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332125", "name": "C1332125#ent", "pos": [12, 13]}}
{"token": ["Avian", "C0080059#ent", "<e1>", "was", "activated", "as", "a", "C0010536#ent", "<e2>", "indicating", "that", "the", "virally", "encoded", "C0080059#ent", "<e1>", "interacts", "normally", "with", "middle", "T", "antigen"], "h": {"id": "C0080059", "name": "C0080059#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [7, 8]}}
{"token": ["The", "327", "and", "GD11", "mAbs", "have", "been", "reported", "to", "be", "specific", "for", "C0080059#ent", "<e1>", "and", "not", "to", "cross-react", "with", "other", "src", "family", "members", "other", "C0010536#ent", "<e2>", "."], "h": {"id": "C0080059", "name": "C0080059#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "transformation", "of", "Xcc750", "sensitive", "plants", "that", "did", "not", "express", "C1414639#ent", "<e1>", ",", "with", "a", "C0669365#ent", "<e2>", "transcribed", "ECS1", "gene", "did", "not", "lead", "to", "the", "resistant", "phenotype", "in", "the", "transgenic", "plants"], "h": {"id": "C1414639", "name": "C1414639#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}}
{"token": ["Overall", ",", "the", "greatest", "proportion", "of", "C1705075#ent", "<e1>", ",", "CCI", ",", "and", "C0004238#ent", "<e2>", "occurred", "in", "free", "stalls", "(", "60", "%", ")", "."], "h": {"id": "C1705075", "name": "C1705075#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "drug", "was", "20x", "more", "potent", "as", "an", "C0597128#ent", "<e1>", "as", "a", "C0042402#ent", "<e2>", "(", "ED50", "0.28", "nmole", "on", "IOP", ",", "5.55", "nmole", "on", "vascular", "effect", "."], "h": {"id": "C0597128", "name": "C0597128#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [14, 15]}}
{"token": ["However", ",", "no", "C0058954#ent", "<e1>", "reversal", "by", "8-OH-DPAT", "was", "found", "when", "5-HT(1A)", "receptors", "protected", "by", "C0290799#ent", "<e2>", "(", "10", "mg", "kg(-1", ")", ")", "30", "min", "before", "C0058954#ent", "<e1>", "."], "h": {"id": "C0290799", "name": "C0290799#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0058954", "name": "C0058954#ent", "pos": [3, 4]}}
{"token": ["Quercetin", ",", "kaemferol", "and", "other", "flavonoids", ",", "except", "C0014485#ent", "<e1>", "and", "silymarin", ",", "inhibited", "both", "C3541394#ent", "<e2>", "."], "h": {"id": "C0014485", "name": "C0014485#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}}
{"token": ["From", "the", "results", "obtained", ",", "(", "-", ")", "C0014485#ent", "<e1>", "was", "seen", "to", "be", "the", "best", "substrate", "for", "both", "C3541394#ent", "<e2>", "with", "the", "OH", "group", "the", "C", "ring", "the", "cis", "position", "respect", "to", "the", "B", "ring"], "h": {"id": "C0014485", "name": "C0014485#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [19, 20]}}
{"token": ["C0013264#ent", "<e1>", "one", "of", "the", "most", "common", "C0015398#ent", "<e2>"], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015398", "name": "C0015398#ent", "pos": [7, 8]}}
{"token": ["C0013264#ent", "<e1>", "DMD", ")", "is", "a", "C0015398#ent", "<e2>", "by", "mutations", "that", "disrupt", "the", "dystrophin", "mRNA", "reading", "frame", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015398", "name": "C0015398#ent", "pos": [6, 7]}}
{"token": ["The", "failure", "of", "such", "effects", "to", "predict", "the", "C1539479#ent", "<e1>", "of", "activated", "T", "cells", "in", "vivo", "that", "C0035690#ent", "<e2>", "shape", "T", "cell", "responses", "via", "mechanisms", "that", "differ", "from", "those", "described", "previously", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035690", "name": "C0035690#ent", "pos": [17, 18]}}
{"token": ["This", "attenuation", "was", "comparable", "to", "that", "provided", "by", "C0053104#ent", "<e1>", "of", "the", "C0237795#ent", "<e2>", "response", "to", "intravenous", "administration", "NPY", "."], "h": {"id": "C0053104", "name": "C0053104#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [12, 13]}}
{"token": ["The", "irreversible", "alpha-adrenoceptor", "and", "NPY", "receptor", "C0053104#ent", "<e1>", "also", "attenuated", "the", "C0237795#ent", "<e2>", "response", "evoked", "by", "the", "low", "doses", "McN-A-343", "but", "not", "the", "increases", "in", "RSNA", "."], "h": {"id": "C0053104", "name": "C0053104#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [11, 12]}}
{"token": ["C0015625#ent", "<e1>", "an", "autosomal", "recessive", "disease", "causing", "C0271909#ent", "<e2>", "congenital", "abnormalities", "associated", "with", "increased", "risk", "of", "tumours", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271909", "name": "C0271909#ent", "pos": [7, 8]}}
{"token": ["With", "the", "exception", "of", "the", "divergent", "C1423974#ent", "<e1>", "and", "beta8", "chains", ",", "the", "C1416496#ent", "<e2>", "short", "and", "highly", "conserved", "sequences", "."], "h": {"id": "C1423974", "name": "C1423974#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416496", "name": "C1416496#ent", "pos": [13, 14]}}
{"token": ["Her", "C0018802#ent", "<e1>", "improved", "with", "digoxin", ",", "furosemide", ",", "and", "C0014025#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [10, 11]}}
{"token": ["He", "received", "treatment", "for", "this", "C0018802#ent", "<e1>", "hypertension", "with", "C0014025#ent", "<e2>", ",", "nifedipine", "and", "fursemide", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [9, 10]}}
{"token": ["The", "double-blind", ",", "placebo-controlled", ",", "multinational", "trial", "Xamoterol", "in", "Severe", "C0018802#ent", "<e1>", "randomized", "290", "patients", "treated", "with", "captopril", "and", "217", "treated", "with", "C0014025#ent", "<e2>", "to", "xamoterol", "or", "placebo", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [22, 23]}}
{"token": ["The", "participation", "of", "the", "C0026741#ent", "<e1>", "the", "hydrolysis", "of", "alpha-limit", "dextrins", "more", "generally", "in", "pathways", "for", "C0054259#ent", "<e2>", "breakdown", "in", "the", "pig", "digestive", "tract", "examined", "and", "discussed", "."], "h": {"id": "C0026741", "name": "C0026741#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [16, 17]}}
{"token": ["Incomplete", "responders", "expressed", "larger", "amounts", "of", "STAT3", ",", "C1334138#ent", "<e1>", ",", "and", "protein", "inhibitor", "activated", "STAT1", "(", "C1413968#ent", "<e2>", ")", "mRNAs", "compared", "to", "complete", "responders", "before", "IQ", "treatment", "."], "h": {"id": "C1334138", "name": "C1334138#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413968", "name": "C1413968#ent", "pos": [17, 18]}}
{"token": ["The", "C1420357#ent", "<e1>", "1-phosphate-induced", "HSP27", "accumulation", "was", "dose", "dependently", "suppressed", "by", "C0297666#ent", "<e2>", ",", "an", "inhibitor", "of", "p38", "MAP", "kinase", "but", "not", "PD98059", ",", "an", "inhibitor", "of", "the", "upstream", "kinase", "activates", "p42/p44", "MAP", "kinase", "."], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0297666", "name": "C0297666#ent", "pos": [11, 12]}}
{"token": ["The", "C2239910#ent", "<e1>", "study", "of", "prevention", "of", "C0729554#ent", "<e2>", "after", "cardiac", "surgery", "the", "total", "amount", "of", "therapeutic", "interventions", "by", "the", "TISS-28", "score", "as", "the", "primary", "endpoint"], "h": {"id": "C2239910", "name": "C2239910#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0729554", "name": "C0729554#ent", "pos": [7, 8]}}
{"token": ["Cyclo", "3", "Fort", "safe", "and", "more", "effective", "than", "C0035976#ent", "<e1>", "in", "the", "treatment", "of", "C0042485#ent", "<e2>", "and", "the", "Cyclo", "3", "Fort", "is", "probably", "associated", "with", "unique", "mechanism", "of", "action", "."], "h": {"id": "C0035976", "name": "C0035976#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042485", "name": "C0042485#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "comparative", "clinical", "study", "to", "evaluate", "the", "efficacy", "of", "the", "association", "of", "alphatocopherol", ",", "C0035976#ent", "<e1>", ",", "melilotus", "officinalis", "and", "centella", "asiatica", "oral", "administration", "patients", "with", "C0042485#ent", "<e2>"], "h": {"id": "C0035976", "name": "C0035976#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0042485", "name": "C0042485#ent", "pos": [29, 30]}}
{"token": ["A", "male", "volunteer", "with", "C0002170#ent", "<e1>", "treated", "simultaneously", "with", "20", "mg", "cyproterone", "acetate", "5", "mg", "C0026196#ent", "<e2>", "topically", "(", "daily", ")", "."], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0026196", "name": "C0026196#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "C0914729#ent", "<e1>", "offers", "clear", "advantages", "over", "sumatriptan", "in", "the", "acute", "treatment", "C0149931#ent", "<e2>", "attacks", "."], "h": {"id": "C0914729", "name": "C0914729#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [13, 14]}}
{"token": ["To", "assess", "the", "interaction", "between", "C0914729#ent", "<e1>", ",", "a", "5-HT1B/1D-receptor", "agonist", "used", "to", "treat", "C0149931#ent", "<e2>", ",", "and", "verapamil", ",", "an", "agent", "for", "C0149931#ent", "<e2>", "prophylaxis", "."], "h": {"id": "C0914729", "name": "C0914729#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [14, 15]}}
{"token": ["In", "20", "cases", "they", "were", "abnormal", "(", "8", "mucopolysaccharidosis", ",", "6", "C0085131#ent", "<e1>", "4", "infantile", "neuroaxonal", "dystrophy", ",", "1", "GM2", "gangliosidosis", "1", "late", "infantile", "ceroid", "C0268279#ent", "<e2>", ")", "."], "h": {"id": "C0085131", "name": "C0085131#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268279", "name": "C0268279#ent", "pos": [25, 26]}}
{"token": ["In", "addition", ",", "mitochondrial", "or", "cytosolic", "catalase", "respiration", "through", "complex", "I", "II", "in", "both", "control", "and", "C1705937#ent", "<e1>", "overexpressing", "cell", "lines", "reverses", "a", "MnSOD-dependent", "decrease", "in", "net", "C2744579#ent", "<e2>", "production", "."], "h": {"id": "C1705937", "name": "C1705937#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [27, 28]}}
{"token": ["The", "short", "C1539521#ent", "<e1>", "cycles", "interacted", "with", "an", "C0752287#ent", "<e2>", "whose", "period", "is", "approximately", "10", "min", "."], "h": {"id": "C1539521", "name": "C1539521#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752287", "name": "C0752287#ent", "pos": [8, 9]}}
{"token": ["In", "Japan", ",", "male", "genital", "herpes", "the", "third", "popular", "male", "C1420519#ent", "<e1>", ",", "the", "most", "popular", "one", "being", "gonococcal", "infection", "the", "second", "C0008149#ent", "<e2>"], "h": {"id": "C1420519", "name": "C1420519#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008149", "name": "C0008149#ent", "pos": [22, 23]}}
{"token": ["Oncogenic", "rearrangements", "the", "C1332080#ent", "<e1>", "ALK", ")", ",", "most", "commonly", "represented", "by", "the", "nucleophosmin/ALK", "fusion", "protein", "C0541106#ent", "<e2>", ")", ",", "are", "involved", "in", "the", "pathogenesis", "of", "anaplastic", "large-cell", "lymphomas", "ALCLs", ")", "."], "h": {"id": "C1332080", "name": "C1332080#ent", "pos": [3, 4]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0541106", "name": "C0541106#ent", "pos": [16, 17]}}
{"token": ["We", "demonstrate", "that", "neural", "crest", "cells", "the", "receptor", "neuropilin", "2", "C2698422#ent", "<e1>", ")", ",", "while", "its", "repulsive", "ligand", "semaphorin", "3F", "(", "C1419946#ent", "<e2>", ")", "is", "restricted", "to", "the", "posterior-half", "somite", "."], "h": {"id": "C2698422", "name": "C2698422#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419946", "name": "C1419946#ent", "pos": [21, 22]}}
{"token": ["All", "patients", "were", "female", ",", "and", "three", "had", "previous", "injections", "for", "C1334103#ent", "<e1>", "the", "affected", "sites", "before", "the", "development", "of", "C0023787#ent", "<e2>", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023787", "name": "C0023787#ent", "pos": [20, 21]}}
{"token": ["All", "patients", "had", "C0340288#ent", "<e1>", "angiographically", "proved", "coronary", "artery", "disease", "evidence", "of", "C0037763#ent", "<e2>", "."], "h": {"id": "C0340288", "name": "C0340288#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037763", "name": "C0037763#ent", "pos": [12, 13]}}
{"token": ["alpha-Amanitin", "sensitivity", "of", "transcription", "indicated", "that", "the", "C0035681#ent", "<e1>", "synthesis", "was", "carried", "out", "by", "C0035680#ent", "<e2>"], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [14, 15]}}
{"token": ["The", "EcoRI", "fragment", "B", "preferentially", "retained", "by", "C0035681#ent", "<e1>", "but", "not", "by", "C0035680#ent", "<e2>"], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [12, 13]}}
{"token": ["Cultures", "of", "mesenteric", "lymph", "nodes", "C1417190#ent", "<e1>", ")", ",", "peripheral", "and", "portal", "blood", "C0023899#ent", "<e2>", ",", "and", "spleen", "were", "performed", "."], "h": {"id": "C1417190", "name": "C1417190#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [13, 14]}}
{"token": ["The", "incidence", "of", "bacterial", "translocation", "the", "C1417190#ent", "<e1>", ",", "spleen", ",", "and", "C0023899#ent", "<e2>", "was", "significantly", "higher", "in", "the", "RA", "group", "."], "h": {"id": "C1417190", "name": "C1417190#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "oxygen-dependent", "recognition", "of", "HIFalpha", "by", "VHL", "triggers", "Rbx1-dependent", "neddylation", "of", "C1332810#ent", "<e1>", ",", "which", "preferentially", "engages", "the", "C1421273#ent", "<e2>"], "h": {"id": "C1332810", "name": "C1332810#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1421273", "name": "C1421273#ent", "pos": [22, 23]}}
{"token": ["The", "ubiquitin", "ligase", "muscle", "atrophy", "F-box", "(", "C1424509#ent", "<e1>", ";", "also", "called", "C3539871#ent", "<e2>", ")", "is", "thought", "to", "play", "important", "roles", "in", "muscle", "loss"], "h": {"id": "C1424509", "name": "C1424509#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539871", "name": "C3539871#ent", "pos": [12, 13]}}
{"token": ["C1414588#ent", "<e1>", ",", "especially", "of", "C2936886#ent", "<e2>", ",", "phosphates", ",", "and", "magnesium", ",", "are", "useful", "in", "clinical", "nutrition", "assess", "mineral", "balance"], "h": {"id": "C1414588", "name": "C1414588#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [5, 6]}}
{"token": ["RT-PCR", "analysis", "C1418768#ent", "<e1>", ",", "Brachyury", "and", "C2827561#ent", "<e2>", "a", "delay", "of", "differentiation", "in", "BCR-ABL", "expressing", "clones", ",", "which", "could", "be", "entirely", "reversed", "upon", "activation", "of", "the", "dominant-negative", "form", "of", "STAT3", "."], "h": {"id": "C1418768", "name": "C1418768#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2827561", "name": "C2827561#ent", "pos": [7, 8]}}
{"token": ["We", "found", "that", "C0211797#ent", "<e1>", "but", "not", "C0292381#ent", "<e2>", "is", "required", "for", "the", "production", "of", "the", "mature", "form", "of", "both", "msDNAs", "."], "h": {"id": "C0211797", "name": "C0211797#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0292381", "name": "C0292381#ent", "pos": [7, 8]}}
{"token": ["In", "terms", "of", "signal", "transduction", "defects", "in", "intracellular", "C1413043#ent", "<e1>", "+", "signalling", "due", "to", "alteration", "of", "expression", "and", "function", "of", "proteins", "that", "regulate", "intracellular", "C1413043#ent", "<e1>", "+", "also", "occur", "in", "C0011847#ent", "<e1>", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [30, 31]}}
{"token": ["C1413043#ent", "<e1>", "+", "-ATPase", "activity", "significantly", "decreased", "at", "all", "weeks", "of", "C0011847#ent", "<e2>", "compared", "to", "control", "group", "p<0.001", ")", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [11, 12]}}
{"token": ["While", "C0771310#ent", "<e1>", "failed", "to", "potentiate", "the", "sedative-hypnotic", "(", "depressant", ")", "effects", "of", "C0001975#ent", "<e2>", ",", "imipramine", "tended", "to", "enhance", "them", "for", "psychomotor", "performance", ",", "memory", "assessments", "and", "some", "subjective", "ratings"], "h": {"id": "C0771310", "name": "C0771310#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [13, 14]}}
{"token": ["Also", ",", "C0771310#ent", "<e1>", "failed", "to", "potentiate", "the", "depressant", "effects", "of", "C0001975#ent", "<e2>", ",", "perhaps", "because", "of", "its", "minimal", "alpha-blockade", "."], "h": {"id": "C0771310", "name": "C0771310#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [11, 12]}}
{"token": ["The", "C2926735#ent", "<e1>", "of", "that", "condition", "was", "somewhat", "longer", "than", "that", "of", "C0006111#ent", "<e2>"], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006111", "name": "C0006111#ent", "pos": [12, 13]}}
{"token": ["The", "C0242898#ent", "<e1>", "GABA", ")", "receptor", "agonist", ",", "C0072076#ent", "<e2>", ",", "was", "administered", "intraperitoneally", "to", "male", "Wistar", "rats"], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072076", "name": "C0072076#ent", "pos": [8, 9]}}
{"token": ["C0242898#ent", "<e1>", "GABA", ")", "receptor", "agonists", "(", "e.g.", "C0072076#ent", "<e2>", ")", "are", "effective", "in", "behavioral", "tests", "predictive", "of", "antidepressant", "drug", "action"], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072076", "name": "C0072076#ent", "pos": [8, 9]}}
{"token": ["C0073177#ent", "<e1>", ",", "physcion", ",", "aloe-emodin", "and", "chrysophanol", "isolated", "from", "Rheum", "emodi", "rhizomes", "C0003308#ent", "<e2>", "Candida", "albicans", "Cryptococcus", "neoformans", "Trichophyton", "mentagrophytes", "Aspergillus", "fumigatus", "MIC", "25", "-", "250", "microg/ml", ")", "."], "h": {"id": "C0073177", "name": "C0073177#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [13, 14]}}
{"token": ["We", "sought", "to", "develop", "a", "simple", "and", "sensitive", "method", "based", "on", "mutant", "allele-specific", "amplification", "(", "C2239387#ent", "<e1>", ")", "for", "the", "detection", "of", "point", "mutations", "in", "the", "C1537502#ent", "<e2>", "blood", "samples"], "h": {"id": "C2239387", "name": "C2239387#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [26, 27]}}
{"token": ["The", "murine", "C1704873#ent", "<e1>", "previously", "mapped", "to", "a", "conserved", "C0017258#ent", "<e2>", "chromosome", "4", "linkage", "homology", "to", "human", "chromosome", "1p32", "36", "."], "h": {"id": "C1704873", "name": "C1704873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017258", "name": "C0017258#ent", "pos": [9, 10]}}
{"token": ["Our", "method", "permits", "detection", "of", "all", "known", "C3540490#ent", "<e1>", "genes", "and", "C0033799#ent", "<e2>", "in", "a", "16-reaction", "set", "."], "h": {"id": "C3540490", "name": "C3540490#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033799", "name": "C0033799#ent", "pos": [11, 12]}}
{"token": ["SES", "feeding", "suppressed", "the", "expression", "of", "the", "lipid-decreasing", "effect", "of", "C2699845#ent", "<e1>", ",", "but", "not", "in", "the", "rats", "C0342895#ent", "<e2>", "on", "PER", "."], "h": {"id": "C2699845", "name": "C2699845#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [18, 19]}}
{"token": ["C1704875#ent", "<e1>", "mRNA", "was", "significantly", "increased", "at", "12", "weeks", "when", "C0149521#ent", "<e2>", "appeared", "in", "the", "WBN/Kob", "rats", "."], "h": {"id": "C1704875", "name": "C1704875#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [10, 11]}}
{"token": ["Neuroprotective", "drugs", "were", "once", "only", "considered", "for", "C1456654#ent", "<e1>", "such", "as", "C0002736#ent", "<e2>", "Parkinson's", "disease", "are", "now", "being", "considered", "in", "MS", "."], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [11, 12]}}
{"token": ["As", "for", "the", "immune", "responses", "C1419805#ent", "<e1>", "in", "drug-treated", "rats", ",", "C0073917#ent", "<e2>", "suppressed", "the", "lymphocyte", "proliferation", "C1419805#ent", "<e1>", ",", "which", "was", "further", "suppressed", "by", "combination", "therapy", "CYA", "."], "h": {"id": "C0073917", "name": "C0073917#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419805", "name": "C1419805#ent", "pos": [5, 6]}}
{"token": ["Inhibition", "of", "C3853644#ent", "<e1>", "a", "dramatic", "reduction", "in", "the", "phosphorylation", "of", "C0086376#ent", "<e2>", "with", "different", "molecular", "weight", "were", "isolated", "from", "the", "cell", "extracts", "anti-phosphotyrosine", "immunoprecipitation", "or", "pull-down", "with", "the", "SH2", "domain", "Src", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Both", "the", "insulin", "receptor", "the", "gene", "product", "the", "Rous", "sarcoma", "virus", "C3853644#ent", "<e1>", ",", "are", "protein", "kinases", "phosphorylate", "themselves", "and", "other", "C0086376#ent", "<e2>", "on", "tyrosine", "residues", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}}
{"token": ["Genes", "characteristically", "expressed", "in", "the", "DFSPs", "included", "PDGF", "beta", "and", "its", "receptor", ",", "C1335202#ent", "<e1>", ",", "APOD", ",", "MEOX1", ",", "PLA2R", ",", "and", "C1335261#ent", "<e2>", "."], "h": {"id": "C1335202", "name": "C1335202#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335261", "name": "C1335261#ent", "pos": [23, 24]}}
{"token": ["The", "opposite", "effects", "of", "lithium", "and", "C0006949#ent", "<e1>", "on", "two", "critical", "transducing", "systems", "a", "model", "for", "the", "C0242911#ent", "<e2>", "these", "agents", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [6, 7]}, "relation": "has_therapeutic_class", "t": {"id": "C0242911", "name": "C0242911#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "neuroendocrine", "and", "sleep", "EEG", "data", "from", "the", "study", "in", "healthy", "subjects", "a", "different", "profile", "of", "action", "for", "C0006949#ent", "<e1>", "compared", "to", "most", "other", "antidepressants", "or", "C0242911#ent", "<e2>"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [19, 20]}, "relation": "has_therapeutic_class", "t": {"id": "C0242911", "name": "C0242911#ent", "pos": [27, 28]}}
{"token": ["Within", "the", "catecholamine", "hypothesis", "of", "affective", "disorders", "the", "reduction", "of", "catecholamine", "turnover", "by", "C0006949#ent", "<e1>", "might", "explain", "the", "reported", "C0242911#ent", "<e2>", "and", "antipsychotic", "effects", "patients", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [13, 14]}, "relation": "has_therapeutic_class", "t": {"id": "C0242911", "name": "C0242911#ent", "pos": [19, 20]}}
{"token": ["Our", "analysis", "of", "C3813609#ent", "<e1>", "in", "a", "number", "of", "arthropods", "reveals", "a", "conserved", "C1517488#ent", "<e2>", "in", "both", "Mandibulates", "and", "Chelicerates", "."], "h": {"id": "C3813609", "name": "C3813609#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [13, 14]}}
{"token": ["These", "abnormalities", "can", "not", "be", "adequately", "explained", "by", "co-existing", "C0023896#ent", "<e1>", "malnutrition", "or", "C0031117#ent", "<e2>", "and", "probably", "represent", "the", "result", "of", "direct", "toxicity", "to", "the", "muscle", "fibres"], "h": {"id": "C0023896", "name": "C0023896#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [13, 14]}}
{"token": ["Zonal", "elution", "studies", "with", "R-", "and", "S-warfarin", "on", "the", "modified", "C0304925#ent", "<e1>", "column", "demonstrated", "the", "importance", "of", "Trp-214", "in", "determining", "the", "stereoselective", "binding", "of", "C0304925#ent", "<e1>", "for", "these", "C0035064#ent", "<e1>", "."], "h": {"id": "C0304925", "name": "C0304925#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [28, 29]}}
{"token": ["Identification", "of", "the", "major", "NBIA", "gene", "has", "led", "to", "more", "accurate", "clinical", "delineation", "the", "C0029896#ent", "<e1>", "that", "comprise", "this", "group", ",", "a", "molecular", "diagnostic", "test", "C0018523#ent", "<e2>", ",", "and", "hypotheses", "for", "treatment", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0018523", "name": "C0018523#ent", "pos": [25, 26]}}
{"token": ["Further", "analysis", "revealed", "that", "the", "amino-terminal", "domain", "MBP-1", "(", "C3539946#ent", "<e1>", "95", ")", "interacts", "with", "C1705404#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705404", "name": "C1705404#ent", "pos": [15, 16]}}
{"token": ["Our", "results", "show", "that", "the", "loss", "of", "repopulating", "activity", "during", "KL", "stimulation", "is", "counteracted", "by", "C3887694#ent", "<e1>", "through", "the", "downregulation", "of", "C3849574#ent", "<e2>", "pathway", "signaling", "."], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [21, 22]}}
{"token": ["C3887694#ent", "<e1>", "induction", "was", "C3849574#ent", "<e2>", "MAP", "kinase", ",", "p38-requiring", "but", "JNK-independent", "."], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [4, 5]}}
{"token": ["Our", "findings", "show", "that", "there", "is", "no", "mislocalization", "of", "C1420588#ent", "<e1>", "to", "the", "cytoplasm", "in", "motor", "neurons", "mutant", "C1420306#ent", "<e2>", "transgenic", "mice", "nor", "association", "of", "C1420588#ent", "<e1>", "with", "ubiquitinated", "inclusions", "."], "h": {"id": "C1420588", "name": "C1420588#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [18, 19]}}
{"token": ["Activity", "of", "C0023816#ent", "<e1>", "levels", "of", "high-density", "lipoprotein", "cholesterol", "increased", "after", "C0290883#ent", "<e2>", "treatment", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0290883", "name": "C0290883#ent", "pos": [11, 12]}}
{"token": ["In", "C0024473#ent", "<e1>", "mice", ",", "the", "percentages", "of", "C0036572#ent", "<e2>", "of", "fatal", "seizures", "were", "dependent", "on", "the", "time", "lapse", "the", "p-chlorophenylalanine", "(", "PCPA", ")", "injection", "and", "the", "audiogenic", "test", "."], "h": {"id": "C0024473", "name": "C0024473#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}}
{"token": ["The", "Pc", "chromobox", "been", "used", "to", "C1875400#ent", "<e1>", "a", "mouse", "C1413157#ent", "<e2>", "M33", ",", "which", "encodes", "a", "predicted", "519", "amino", "acid", "protein"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413157", "name": "C1413157#ent", "pos": [10, 11]}}
{"token": ["C1366480#ent", "<e1>", "was", "shown", "to", "be", "a", "ligand", "for", "C1416655#ent", "<e2>", "by", "cross-linking", "125I-labeled", "C1366480#ent", "<e1>", "to", "c-kit-expressing", "cells", "with", "subsequent", "immunoprecipitation", "of", "the", "complex", "with", "antiserum", "specific", "for", "the", "C-terminus", "of", "c-kit"], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [9, 10]}}
{"token": ["C0024790#ent", "<e1>", "PNH", ")", "is", "an", "acquired", "clonal", "hematologic", "stem", "cell", "disorder", "as", "an", "C0002878#ent", "<e2>"], "h": {"id": "C0024790", "name": "C0024790#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [14, 15]}}
{"token": ["The", "surface", "active", "component", "of", "alasan", "is", "a", "35.77", "kDa", "protein", "AlnA.", "Although", "AlnA", "and", "the", "C0950080#ent", "<e1>", "C0039683#ent", "<e2>", ")", "have", "a", "high", "amino", "acid", "sequence", "homology", ",", "E.", "coli", "C0039683#ent", "<e2>", "has", "no", "emulsifying", "activity"], "h": {"id": "C0950080", "name": "C0950080#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0039683", "name": "C0039683#ent", "pos": [18, 19]}}
{"token": ["In", "oriC-independent", "replication", ",", "C0033164#ent", "<e1>", "recognize", "the", "C1880218#ent", "<e2>", "or", "R-loop", "structure", ",", "respectively", ",", "to", "initiate", "assembly", "of", "a", "primosome", "which", "mediates", "primer", "RNA", "synthesis", "and", "replication", "fork", "progression"], "h": {"id": "C0033164", "name": "C0033164#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1880218", "name": "C1880218#ent", "pos": [8, 9]}}
{"token": ["Spontaneous", "insulin-dependent", "diabetes", "mellitus", "C3273872#ent", "<e1>", ")", "and", "other", "autoimmune", "manifestations", "such", "as", "C0677607#ent", "<e2>", "atrophic", "gastritis", "develop", "in", "diabetes-prone", "(", "high-risk", ")", "lines", "of", "Wistar-derived", "BioBreeding", "(", "BB", ")", "rats", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [13, 14]}}
{"token": ["We", "report", "a", "79-year-old", "woman", "case", "of", "slowly", "progressive", "C3273872#ent", "<e1>", "(", "SPIDDM", ")", "with", "rheumatoid", "arthritis", "RA", ")", "and", "C0677607#ent", "<e2>"], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [20, 21]}}
{"token": ["Homology", "analyses", "that", "hCyPB", "is", "a", "member", "of", "the", "cyclophilin", "B", "C1418795#ent", "<e1>", ")", "family", ",", "which", "includes", "yeast", "C1418795#ent", "<e1>", ",", "Drosophila", "nina", "A", "and", "rat", "C1567679#ent", "<e1>"], "h": {"id": "C1418795", "name": "C1418795#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1567679", "name": "C1567679#ent", "pos": [27, 28]}}
{"token": ["The", "effects", "of", "cis-platin", "and", "two", "novel", "C3536920#ent", "<e1>", "D19466", "(", "lobaplatin", ")", "and", "D17872", ",", "on", "C0079068#ent", "<e2>", "promoter", "regions", "studied", "using", "a", "large", "range", "of", "drug", "concentrations", "correlated", "with", "cytotoxicity", "data", "."], "h": {"id": "C3536920", "name": "C3536920#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [17, 18]}}
{"token": ["Reduced", "transcript", "levels", "for", "fatty", "acid", "binding", "protein", "5", "FABP5", ")", "and", "plexin", "D1", "C1418668#ent", "<e1>", ")", ",", "and", "increased", "levels", "for", "aquaporin", "3", "C0256421#ent", "<e2>", ")", "were", "confirmed", "by", "quantitative", "real-time", "polymerase", "chain", "reaction"], "h": {"id": "C1418668", "name": "C1418668#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0256421", "name": "C0256421#ent", "pos": [24, 25]}}
{"token": ["Reduced", "transcript", "levels", "for", "fatty", "acid", "binding", "protein", "5", "FABP5", ")", "and", "C1418668#ent", "<e1>", "PLXND1", ")", ",", "and", "increased", "levels", "for", "aquaporin", "3", "C0256421#ent", "<e2>", ")", "were", "confirmed", "by", "quantitative", "real-time", "polymerase", "chain", "reaction"], "h": {"id": "C1418668", "name": "C1418668#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0256421", "name": "C0256421#ent", "pos": [23, 24]}}
{"token": ["Reduced", "transcript", "levels", "for", "fatty", "acid", "binding", "protein", "5", "FABP5", ")", "and", "plexin", "D1", "C1418668#ent", "<e1>", ")", ",", "and", "increased", "levels", "for", "C0256421#ent", "<e2>", "AQP3", ")", "were", "confirmed", "by", "quantitative", "real-time", "polymerase", "chain", "reaction"], "h": {"id": "C1418668", "name": "C1418668#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0256421", "name": "C0256421#ent", "pos": [22, 23]}}
{"token": ["In", "the", "brain", "and", "thymus", "the", "C2697656#ent", "<e1>", "induced", "ornithine", "decarboxylase", "but", "not", "C0019605#ent", "<e2>"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019605", "name": "C0019605#ent", "pos": [13, 14]}}
{"token": ["Immunocytochemical", "analysis", "the", "BM", "cells", "W/Wv", "mice", "treated", "with", "mrGM-CSF", "and", "C2697656#ent", "<e1>", "showed", "that", "C0019605#ent", "<e2>", "was", "in", "the", "cytoplasm", "of", "cells", "having", "Mac-1", ",", "a", "macrophage-differentiation", "antigen"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0019605", "name": "C0019605#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "treatment", "with", "mrGM-CSF", "made", "the", "cells", "respond", "to", "C2697656#ent", "<e1>", "by", "a", "dose-dependent", "increase", "in", "C0019605#ent", "<e2>", "activity", "and", "histamine", "synthesis", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0019605", "name": "C0019605#ent", "pos": [18, 19]}}
{"token": ["These", "results", "suggest", "that", "secretion", "of", "corticosterone", "caused", "by", "C2697656#ent", "<e1>", "is", "mediated", "by", "histamine", "produced", "through", "induction", "of", "C0019605#ent", "<e2>", "non-mast", "cells", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019605", "name": "C0019605#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "LRRK2", ",", "encoding", "leucine-rich", "repeat", "kinase", "2", "or", "Dardarin", ")", ",", "cause", "C2936739#ent", "<e1>", "Parkinson's", "disease", "AdPD", ")", "and", "are", "also", "found", "in", "sporadic", "PD", "C3273505#ent", "<e2>", ")", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3273505", "name": "C3273505#ent", "pos": [27, 28]}}
{"token": ["The", "present", "study", "shows", "that", ",", "unlike", "other", "known", "peroxidases", ",", "C1704716#ent", "<e1>", "activity", "requires", "the", "addition", "of", "substrate", ",", "C1337106#ent", "<e2>", ",", "prior", "to", "the", "cosubstrate", ",", "peroxide", "."], "h": {"id": "C1704716", "name": "C1704716#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1337106", "name": "C1337106#ent", "pos": [20, 21]}}
{"token": ["Our", "recent", "work", "identifying", "C1417664#ent", "<e1>", "as", "an", "activator", "of", "the", "C0971285#ent", "<e2>", "a", "novel", "hub", "for", "such", "integrated", "signaling", "."], "h": {"id": "C1417664", "name": "C1417664#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0971285", "name": "C0971285#ent", "pos": [11, 12]}}
{"token": ["The", "synthesis", "and", "C4283882#ent", "<e1>", "of", "a", "series", "of", "pyrrolopyridazine", "C2347168#ent", "<e2>", "reported", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2347168", "name": "C2347168#ent", "pos": [10, 11]}}
{"token": ["Chemical", "cross-linking", "focal", "adhesion", "preparations", "with", "Lomant's", "reagent", "molecular", "proximity", "endogenous", "C1335240#ent", "<e1>", "and", "tensin", ",", "whereas", "neither", "C0059239#ent", "<e2>", "vinculin", "was", "cross-linked", "and", "co-precipitated", "with", "C1335240#ent", "<e1>", ",", "suggesting", "distinct", "spatial", "subdomains", "within", "adhesions", "."], "h": {"id": "C1335240", "name": "C1335240#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [18, 19]}}
{"token": ["C2987364#ent", "<e1>", "(", "WT", ")", "or", "kinase-inactive", "(", "K269E", ")", "mutant", "C0084219#ent", "<e2>", "co-expressed", "with", "bovine", "GAP", "using", "the", "baculovirus/Sf-9", "cell", "system", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0084219", "name": "C0084219#ent", "pos": [11, 12]}}
{"token": ["When", "uniform", "transformation", "of", "all", "C0242965#ent", "<e1>", "obtained", ",", "the", "marker", "genes", "be", "excised", "by", "C1511573#ent", "<e2>", "or", "Int", "expressed", "from", "a", "nuclear", "gene"], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [15, 16]}}
{"token": ["The", "deleted", "C0242965#ent", "<e1>", "in", "the", "seed", "progeny", "C1511573#ent", "<e2>", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [8, 9]}}
{"token": ["Depending", "on", "the", "clinical", "situation", "or", "the", "clinical", "patient's", "evolution", ",", "the", "use", "of", "C0009014#ent", "<e1>", ",", "haloperidol", "or", "C0246631#ent", "<e2>", "could", "be", "better", "options", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0246631", "name": "C0246631#ent", "pos": [19, 20]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "type", "and", "distribution", "of", "C0206062#ent", "<e1>", "in", "patients", "with", "C0085655#ent", "<e2>", "and", "dermatomyositis", ",", "using", "high-resolution", "computed", "tomography", "HRCT", ")", "."], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085655", "name": "C0085655#ent", "pos": [18, 19]}}
{"token": ["Recently", "it", "has", "been", "demonstrated", "that", "transcutaneous", "delivery", "of", "ultrasound", "combined", "with", "tissue", "plasminogen", "activator", "C0872913#ent", "<e1>", ")", "is", "more", "effective", "than", "C0872913#ent", "<e1>", "alone", "in", "recanalizing", "acutely", "C0010072#ent", "<e1>"], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0010072", "name": "C0010072#ent", "pos": [28, 29]}}
{"token": ["In", "fact", ",", "only", "30", "%", "of", "MA", "patients", "had", "typical", "C0268731#ent", "<e1>", "while", "40", "%", "had", "more", "advanced", "C0238304#ent", "<e2>", "and/or", "vascular", "lesions", "30", "%", "had", "normal", "renal", "structure"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0238304", "name": "C0238304#ent", "pos": [19, 20]}}
{"token": ["In", "normal", "renal", "tissue", "the", "expression", "of", "vimentin", "was", "restricted", "to", "C0268731#ent", "<e1>", "but", "in", "all", "cases", "of", "C0238304#ent", "<e2>", "extended", "to", "the", "cortical", "tubular", "epithelia", "and", "was", "correlated", "with", "the", "degree", "of", "tubulo-interstitial", "damage"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0238304", "name": "C0238304#ent", "pos": [18, 19]}}
{"token": ["Four", "infectious", "processes", "preponderant", ":", "Cryptococcosis", ",", "C2350529#ent", "<e1>", ",", "nocardiosis", ",", "or", "Pneumocystis", "carinii", "C1535939#ent", "<e2>", "occurred", "in", "21", "patients", "."], "h": {"id": "C2350529", "name": "C2350529#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [15, 16]}}
{"token": ["Data", "derived", "from", "mouse", "macrophage", "studies", "were", "further", "confirmed", "using", "cell", "lines", "expressing", "human", "C1420567#ent", "<e1>", ",", "and", "showed", "that", "C1420449#ent", "<e2>", "also", "binds", "to", "the", "human", "receptor"], "h": {"id": "C1420567", "name": "C1420567#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420449", "name": "C1420449#ent", "pos": [20, 21]}}
{"token": ["This", "study", "demonstrates", "a", "much", "higher", "prevalence", "of", "splenomegaly", "in", "Arab", "children", "with", "C0398650#ent", "<e1>", "most", "probably", "related", "to", "associated", "C0240066#ent", "<e2>"], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0240066", "name": "C0240066#ent", "pos": [20, 21]}}
{"token": ["In", "this", "patient", ",", "the", "initial", "manifestations", "of", "C0398650#ent", "<e1>", "modified", "by", "the", "presence", "of", "severe", "C0240066#ent", "<e2>"], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0240066", "name": "C0240066#ent", "pos": [16, 17]}}
{"token": ["Under", "these", "conditions", "C0030040#ent", "<e1>", "migrated", "at", "4.76+/-0.05", "min", "and", "C0040233#ent", "<e2>", "at", "4.97+/-0.05", "min", "."], "h": {"id": "C0030040", "name": "C0030040#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040233", "name": "C0040233#ent", "pos": [10, 11]}}
{"token": ["Ectopic", "expression", "of", "C1413706#ent", "<e1>", "C1422492#ent", "<e2>", "enhanced", "activity", "of", "the", "NUE", ",", "indicating", "that", "C1413706#ent", "<e1>", "is", "an", "essential", "regulator", "of", "NIS", "gene", "expression", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413706", "name": "C1413706#ent", "pos": [3, 4]}}
{"token": ["Furthermore", ",", "mRNAs", "of", "ACT", "(", "C1422492#ent", "<e1>", "of", "C1413706#ent", "<e2>", "in", "testis", ")", "and", "C1413706#ent", "<e2>", "target", "genes", "are", "downregulated", "in", "miwi(null", ")", "testes", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413706", "name": "C1413706#ent", "pos": [9, 10]}}
{"token": ["Numerous", "putative", "targets", "of", "PAX3", "and", "C1709387#ent", "<e1>", "were", "identified", "and", "six", "C1417679#ent", "<e2>", ",", "Itm2A", ",", "Fath", ",", "FLT1", ",", "TGFA", ",", "BVES", ",", "and", "EN2", ",", "were", "examined", "closely", "."], "h": {"id": "C1709387", "name": "C1709387#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Twenty-three", "of", "them", "had", "only", "C0037284#ent", "<e1>", "21", "had", "both", "C0037284#ent", "<e1>", "C0022408#ent", "<e1>", "."], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [12, 13]}}
{"token": ["Two", "patients", "with", "C0017925#ent", "<e1>", "presented", "who", "show", "severe", "stenosis", "of", "the", "lumbar", "canal", "C0013456#ent", "<e2>", "neurological", "compression"], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013456", "name": "C0013456#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "report", "the", "cloning", "and", "characterization", "of", "a", "novel", "C0096069#ent", "<e1>", "HVH2", ",", "which", "may", "function", "in", "vivo", "a", "C0096069#ent", "<e1>"], "h": {"id": "C0096069", "name": "C0096069#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0096069", "name": "C0096069#ent", "pos": [10, 11]}}
{"token": ["whereas", "it", "markedly", "inhibited", "the", "C0237795#ent", "<e1>", "response", "to", "the", "partial", "alpha", "1-adrenoceptor", "of", "the", "C0030071#ent", "<e2>", "in", "the", "presence", "of", "rauwolscine", ",", "1", "mg/kg", ",", "i.v", ".", ")", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030071", "name": "C0030071#ent", "pos": [15, 16]}}
{"token": ["Finally", ",", "since", "treatment", "of", "filariases", "at", "present", "depends", "on", "C0003404#ent", "<e1>", "the", "clinical", "indications", "dosages", "of", "C0012191#ent", "<e2>", "and", "ivermectin", "are", "summarized", "."], "h": {"id": "C0003404", "name": "C0003404#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012191", "name": "C0012191#ent", "pos": [17, 18]}}
{"token": ["We", "observed", "that", "C1367476#ent", "<e1>", "is", "a", "relatively", "weak", "activator", "of", "the", "mitogen-activated", "protein", "kinase/extracellular-signal-regulated", "kinases", "C1334474#ent", "<e2>", ")", "when", "compared", "to", "the", "H-Ras", "oncogene", "."], "h": {"id": "C1367476", "name": "C1367476#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [16, 17]}}
{"token": ["C1333897#ent", "<e1>", "controls", "central", "C1417405#ent", "<e2>", "as", "glycolysis", ",", "angiogenesis", ",", "and", "invasion", "."], "h": {"id": "C1333897", "name": "C1333897#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417405", "name": "C1417405#ent", "pos": [4, 5]}}
{"token": ["The", "C0991617#ent", "<e1>", "selected", "for", "the", "algorithm", "were", "intravenous", "C0015620#ent", "<e2>", "and", "omeprazole", "suspension", "or", "tablets", ",", "depending", "on", "the", "available", "administration", "route", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015620", "name": "C0015620#ent", "pos": [9, 10]}}
{"token": ["H2-receptor", "blocking", "C0991617#ent", "<e1>", "cimetidine", ",", "ranitidine", "and", "C0015620#ent", "<e2>", "have", "qualitatively", "a", "different", "pharmocodynamic", "spectrum", "of", "side", "effects", "to", "differences", "in", "chemical", "structure"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015620", "name": "C0015620#ent", "pos": [8, 9]}}
{"token": ["In", "the", "present", "study", "we", "searched", "for", "restriction", "fragment", "length", "polymorphisms", "RFLP", ")", "in", "the", "human", "interleukin-1", "beta", "IL-1", "beta)", "gene", "for", "correlations", "to", "monocyte", "(", "Mo", ")", "function", "in", "C1418941#ent", "<e1>", "healthy", "donors", "and", "C0011860#ent", "<e2>", "patients", "."], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [30, 31]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [35, 36]}}
{"token": ["Partially", "purified", "C1334133#ent", "<e1>", "bound", "tightly", "to", "bacterial", "fusion", "proteins", "the", "N-", "or", "C-terminal", "SH2", "domains", "PtdIns", "3'-kinase", "regulatory", "subunit", "C1423078#ent", "<e2>", ")", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423078", "name": "C1423078#ent", "pos": [20, 21]}}
{"token": ["Highly", "purified", "C1334133#ent", "<e1>", "phosphorylated", "the", "purified", "C1423078#ent", "<e2>", "of", "PI", "3-kinase", "the", "bovine", "thymus", "p1", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423078", "name": "C1423078#ent", "pos": [7, 8]}}
{"token": ["We", "studied", "959", "C1535939#ent", "<e1>", "patients", "and", "determined", "C0042071#ent", "<e2>", "content", "in", "911", "(", "95", "%", ")", "of", "them", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [8, 9]}}
{"token": ["An", "almost", "normal", "increase", "in", "serum", "1,25(OH)2D", "was", "observed", "in", "two", "patients", "with", "C1704375#ent", "<e1>", "one", "with", "Lowe's", "syndrome", "the", "other", "with", "C0015624#ent", "<e2>"], "h": {"id": "C1704375", "name": "C1704375#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [22, 23]}}
{"token": ["It", "is", "expected", "that", "other", "contiguous", "C0039082#ent", "<e1>", "be", "recognized", "eventually", ";", "C1530423#ent", "<e2>", "and", "Cornelia", "de", "Lange", "syndromes", "prime", "candidates", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1530423", "name": "C1530423#ent", "pos": [12, 13]}}
{"token": ["In", "Saccharomyces", "cerevisiae", "ICL", "repair", "factors", "from", "all", "of", "the", "three", "major", "repair", "groups", "nucleotide", "excision", "repair", "C1843013#ent", "<e1>", "epistasis", "group", ")", ",", "post-replication", "repair", "C3811702#ent", "<e2>", "epistasis", "group", ")", "and", "recombinational", "repair", "RAD52", "epistasis", "group", ")", "."], "h": {"id": "C1843013", "name": "C1843013#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3811702", "name": "C3811702#ent", "pos": [25, 26]}}
{"token": ["Two", "patients", "had", "been", "exposed", "to", "C3536710#ent", "<e1>", "in", "early", "pregnancy", "one", "of", "them", "had", "hyposadias", "and", "C0156312#ent", "<e2>"], "h": {"id": "C3536710", "name": "C3536710#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0156312", "name": "C0156312#ent", "pos": [17, 18]}}
{"token": ["Under", "conditions", "in", "which", "C0003403#ent", "<e1>", "treatment", "results", "in", "reduced", "C0079068#ent", "<e2>", "transcripts", ",", "there", "is", "no", "effect", "on", "total", "RNA", "synthesis", ",", "growth", "rate", "or", "saturation", "density"], "h": {"id": "C0003403", "name": "C0003403#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [10, 11]}}
{"token": ["Immunosuppression", "included", "cyclosporine", "(", "Neoral", ")", ",", "C0038317#ent", "<e1>", ",", "and", "azathioprine", "with", "conversion", "to", "tacrolimus", "(", "C3273455#ent", "<e2>", ")", "as", "indicated", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273455", "name": "C3273455#ent", "pos": [17, 18]}}
{"token": ["C1704793#ent", "<e1>", "did", "not", "change", "after", "H1", "but", "increased", "after", "C0919509#ent", "<e2>", ",", "and", "the", "H2", "response", "larger", "(", "P", "less", "than", "0.01", ")", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [10, 11]}}
{"token": ["The", "adrenal", "sensitivity", "C1704793#ent", "<e1>", "increased", "after", "C0919509#ent", "<e2>", "on", "day", "2", "and", "was", "similar", "after", "C0919509#ent", "<e2>", "on", "both", "days", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [7, 8]}}
{"token": ["Treatment", "of", "selected", "plasmas", "with", "C0027803#ent", "<e1>", "demonstrated", "that", "the", "microheterogeneity", "observed", "in", "the", "PIA", ",", "C1420358#ent", "<e2>", ",", "PIC", "and", "PID", "proteins", "was", "attributable", "to", "sialic", "acid", "additions", "."], "h": {"id": "C0027803", "name": "C0027803#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420358", "name": "C1420358#ent", "pos": [16, 17]}}
{"token": ["The", "results", "of", "examination", "of", "102", "patients", "with", "C0023882#ent", "<e1>", "ICP", ")", "with", "C0242966#ent", "<e2>", "ES", ")", "at", "the", "age", "from", "3", "months", "to", "14", "years", "are", "presented", "."], "h": {"id": "C0023882", "name": "C0023882#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242966", "name": "C0242966#ent", "pos": [13, 14]}}
{"token": ["The", "major", "clinical", "features", "are", "C0023895#ent", "<e1>", ",", "peripheral", "neuropathy", "corneal", "anesthesia", "scarring", ",", "acral", "mutilation", ",", "C1858991#ent", "<e2>", "failure", "to", "thrive", ",", "and", "recurrent", "metabolic", "acidosis", "intercurrent", "infections"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1858991", "name": "C1858991#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "overexpression", "of", "C1415857#ent", "<e1>", "in", "an", "C1333669#ent", "<e2>", "induced", "cells", "to", "round", "up", "and", "die", "by", "apoptosis", "."], "h": {"id": "C1415857", "name": "C1415857#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333669", "name": "C1333669#ent", "pos": [8, 9]}}
{"token": ["Removal", "of", "cytosolic", "ATP", "by", "preincubation", "with", "hexokinase", "and", "glucose", ",", "dialysis", "of", "C3538760#ent", "<e1>", "chelation", "of", "C2936886#ent", "<e2>", "with", "EGTA", "did", "not", "abolish", "the", "stimulatory", "effect", "of", "arachidonic", "acid", "GTP[gamma", "S", "."], "h": {"id": "C3538760", "name": "C3538760#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [17, 18]}}
{"token": ["The", "chromosomal", "translocation", "t(14;18", ")", "in", "lymphoma", "leads", "to", "an", "C0221406#ent", "<e1>", "of", "the", "Bcl-2", "protein", "the", "basis", "of", "increased", "C0376515#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [20, 21]}}
{"token": ["These", "data", "provide", "evidence", "for", "an", "important", "stimulatory", "role", "of", "C3273648#ent", "<e1>", "in", "promoting", "C3537334#ent", "<e2>", "expression", "in", "rat", "liver", "."], "h": {"id": "C3273648", "name": "C3273648#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3537334", "name": "C3537334#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "the", "use", "of", "C0069805#ent", "<e1>", ",", "a", "compound", "with", "C0242896#ent", "<e2>", ",", "smooth", "muscle", "relaxant", "and", "local", "anesthetic", "effects", "has", "become", "widely", "used", "with", "both", "oral", "and", "intravesical", "administration"], "h": {"id": "C0069805", "name": "C0069805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [11, 12]}}
{"token": ["Experiments", "have", "been", "conducted", "which", "show", "that", "while", "the", "C0069805#ent", "<e1>", "only", "moderate", "in", "vitro", "C0242896#ent", "<e2>", "and", "antihistaminic", "activity", "it", "is", "a", "potent", "inhibitor", "of", "barium", "chloride-induced", "spasms", "of", "rabbit", "detrusor", "muscle", "."], "h": {"id": "C0069805", "name": "C0069805#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [15, 16]}}
{"token": ["In", "undigested", ",", "matrix-laden", "fibroblasts", ",", "C1704816#ent", "<e1>", "significantly", "downregulates", "C1414382#ent", "<e2>", "mRNA", "via", "activation", "of", "epidermal", "growth", "factor", "receptor"], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "C1414168#ent", "<e1>", "already", "been", "implicated", "in", "the", "genetic", "disorder", "C2931123#ent", "<e2>"], "h": {"id": "C1414168", "name": "C1414168#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2931123", "name": "C2931123#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "WHI-P154", ",", "an", "inhibitor", "of", "Janus", "protein", "tyrosine", "kinase", "C0253457#ent", "<e1>", ")", ",", "Hck", "and", "C1335892#ent", "<e2>", ",", "prevented", "PDGF-induced", "neurite", "outgrowth", "."], "h": {"id": "C0253457", "name": "C0253457#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [18, 19]}}
{"token": ["We", "studied", "the", "glycosylation", "of", "the", "protein", "using", "C2681929#ent", "<e1>", "peptide-N4-(N-acetyl-beta-glucosaminyl)-asparagine", "amidase", "digestion", "of", "oligosaccharide", "side", "chains", "the", "two", "forms", "of", "C1420044#ent", "<e2>", "."], "h": {"id": "C2681929", "name": "C2681929#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420044", "name": "C1420044#ent", "pos": [21, 22]}}
{"token": ["Synovex", "did", "not", "affect", "fiber", "area", "compared", "with", "control", "steers", "whereas", "C0878199#ent", "<e1>", "and", "Revalor", "implants", "to", "larger", "fibers", "in", "C1419283#ent", "<e2>", "3", "and", "4", ",", "respectively", "."], "h": {"id": "C0878199", "name": "C0878199#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419283", "name": "C1419283#ent", "pos": [20, 21]}}
{"token": ["We", "report", "here", "that", "tc-ptp(-/-", ")", "mice", "develop", "progressive", "systemic", "inflammatory", "disease", "shown", "by", "C0027059#ent", "<e1>", "gastritis", ",", "nephritis", ",", "and", "C0037023#ent", "<e2>", "as", "well", "as", "elevated", "serum", "interferon-gamma", "."], "h": {"id": "C0027059", "name": "C0027059#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0037023", "name": "C0037023#ent", "pos": [21, 22]}}
{"token": ["Although", "not", "advanced", "to", "clinical", "trials", "C0663242#ent", "<e1>", "demonstrated", "potency", "comparable", "to", "that", "of", "C0663241#ent", "<e2>", "and", "had", "identical", "interpretive", "testing", "criteria", "."], "h": {"id": "C0663242", "name": "C0663242#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0663241", "name": "C0663241#ent", "pos": [14, 15]}}
{"token": ["Experiments", "with", "a", "susceptible", "Escherichia", "coli", "strain", "UC6782", ",", "demonstrated", "that", "in", "vivo", "protein", "synthesis", "inhibited", "by", "both", "C0663242#ent", "<e1>", "(", "formerly", "U-100592", ")", "and", "C0663241#ent", "<e2>", "(", "formerly", "U-100766", ")", "."], "h": {"id": "C0663242", "name": "C0663242#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0663241", "name": "C0663241#ent", "pos": [25, 26]}}
{"token": ["The", "purpose", "of", "this", "study", "to", "compare", "breast", "milk", "pharmacokinetics", "between", "C0085174#ent", "<e1>", "200", "mug", "and", "C0025760#ent", "<e2>", "250", "mug", "after", "single", "oral", "dosing", "in", "women", "who", "require", "postpartum", "uterotonic", "therapy", "."], "h": {"id": "C0085174", "name": "C0085174#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025760", "name": "C0025760#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "the", "extent", "of", ",", "and", "basis", "for", ",", "abnormalities", "in", "the", "flicker", "electroretinogram", "ERG", ")", "of", "the", "cone", "system", "patients", "with", "C0271091#ent", "<e1>", "XLRS", ")", ",", "a", "form", "of", "C1860405#ent", "<e2>"], "h": {"id": "C0271091", "name": "C0271091#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1860405", "name": "C1860405#ent", "pos": [31, 32]}}
{"token": ["We", "selected", "two", "probes", ":", "C1384510#ent", "<e1>", "and", "a", "probe", "comprising", "the", "cDNA", "of", "the", "transcription", "factor", "C1332801#ent", "<e2>", ",", "which", "expresses", "a", "low", "abundant", "mRNA", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332801", "name": "C1332801#ent", "pos": [17, 18]}}
{"token": ["S.", "aureus", "a", "unique", "pathogen", "because", "of", "its", "virulent", "properties", ",", "its", "C0029166#ent", "<e1>", "and", "its", "ability", "to", "cause", "C0014118#ent", "<e2>", "on", "architecturally", "normal", "cardiac", "valves"], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [19, 20]}}
{"token": ["With", "increasing", "C0029166#ent", "<e1>", "generalized", "infections", "characteristic", ",", "such", "as", "arthritis", ",", "polyarthritis", ",", "C0014118#ent", "<e2>", ",", "nephritis", ",", "osteomyelitis", "and", "embolic", "pneumonia"], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [14, 15]}}
{"token": ["In", "the", "TSA-treated", "cells", ",", "expression", "levels", "histone", "deacetylases", "DNA", "methyltransferases", "reduced", ",", "but", "the", "expression", "level", "of", "C0671924#ent", "<e1>", "as", "Tip60", "and", "C1333890#ent", "<e2>", "HAT1", ")", "did", "not", "change", "compared", "with", "normal", "cells"], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333890", "name": "C1333890#ent", "pos": [23, 24]}}
{"token": ["We", "have", "analyzed", "the", "C0671924#ent", "<e1>", "enzymes", "obtained", "from", "a", "series", "of", "C1333890#ent", "<e2>", "hat2", ",", "and", "gcn5", "single", "mutants", "and", "hat1,hat2", "and", "hat1,gcn5", "double", "mutants", "."], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333890", "name": "C1333890#ent", "pos": [12, 13]}}
{"token": ["Among", "these", "7", "patients", ",", "five", "were", "C0085215#ent", "<e1>", "and", "the", "remaining", "two", "were", "C0022735#ent", "<e2>", "."], "h": {"id": "C0085215", "name": "C0085215#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022735", "name": "C0022735#ent", "pos": [14, 15]}}
{"token": ["Both", "primary", "C0085215#ent", "<e1>", "and", "secondary", "C0022735#ent", "<e2>", "appear", "with", "cerebellar", "ataxia"], "h": {"id": "C0085215", "name": "C0085215#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022735", "name": "C0022735#ent", "pos": [6, 7]}}
{"token": ["The", "intensity", "of", "the", "C1414461#ent", "<e1>", "signal", "was", "increased", "by", "C0038838#ent", "<e2>", "and", "decreased", "under", "anaerobic", "conditions", ",", "amounting", "to", "only", "20", "%", "of", "the", "intensity", "detected", "in", "the", "aerobic", "reaction"], "h": {"id": "C1414461", "name": "C1414461#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [10, 11]}}
{"token": ["We", "report", "the", "effectiveness", "of", "acitretin", "in", "C1416692#ent", "<e1>", "in", "combination", "with", "C0953467#ent", "<e2>", "."], "h": {"id": "C1416692", "name": "C1416692#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0953467", "name": "C0953467#ent", "pos": [12, 13]}}
{"token": ["By", "contrast", ",", "vascular", "malformations", "not", "express", "C1366837#ent", "<e1>", "vascular", "endothelial", "growth", "factor", "bFGF", ",", "type", "IV", "collagenase", "and", "C0042071#ent", "<e2>", "."], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", "we", "sought", "to", "determine", "the", "relative", "role", "of", "C1332714#ent", "<e1>", "and", "CD8", "T", "cells", "Mycobacterium", "w-induced", "protective", "immunity", "C0041323#ent", "<e2>", "of", "mice", "by", "in", "vivo", "depletion", "with", "specific", "monoclonal", "antibodies", "mAb", ")", "."], "h": {"id": "C1332714", "name": "C1332714#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [22, 23]}}
{"token": ["Diseased", "hearts", "had", "a", "significant", "increase", "in", "C0907533#ent", "<e1>", "mRNA", "and", "protein", "expression", "and", "activity", "associated", "with", "translocation", "of", "C0907533#ent", "<e1>", "to", "the", "sarcolemma", "through", "interactions", "with", "C1413146#ent", "<e1>"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413146", "name": "C1413146#ent", "pos": [27, 28]}}
{"token": ["C1416797#ent", "<e1>", "the", "baseline", "did", "not", "correlate", "with", "C0077656#ent", "<e2>", "or", "tocopherol", "parameters", ",", "or", "with", "any", "plasma", "lipid", "or", "lipoprotein", "levels", "."], "h": {"id": "C1416797", "name": "C1416797#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0077656", "name": "C0077656#ent", "pos": [8, 9]}}
{"token": ["Standard", "teaching", "that", "C0040921#ent", "<e1>", "is", "an", "important", "cause", "of", "C0042267#ent", "<e2>", "in", "women", ",", "but", "that", "male", "sexual", "partners", "experience", "little", "or", "no", "morbidity"], "h": {"id": "C0040921", "name": "C0040921#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0042267", "name": "C0042267#ent", "pos": [10, 11]}}
{"token": ["As", "assessed", "by", "whole-cell", "patch", "clamp", ",", "fenofibrate", ",", "fenofibric", "acid", "troglitazone", ",", "and", "15-deoxy-Delta12,14-PGJ2", "reduced", "the", "C1955862#ent", "<e1>", "currents", ",", "and", "inhibition", "continued", "after", "washout", "of", "these", "C0035064#ent", "<e2>", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [28, 29]}}
{"token": ["The", "C1955862#ent", "<e1>", "be", "pharmacologically", "modulated", "by", "a", "family", "of", "structurally", "diverse", "C0035064#ent", "<e2>", "of", "varied", "potency", "and", "selectivity", ",", "collectively", "known", "as", "potassium", "channel", "openers", "blockers", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [12, 13]}}
{"token": ["The", "human", "C0961834#ent", "<e1>", "recently", "been", "shown", "to", "encode", "a", "novel", "DNA", "polymerase", "C1418734#ent", "<e2>", "poliota", ")", "."], "h": {"id": "C0961834", "name": "C0961834#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418734", "name": "C1418734#ent", "pos": [13, 14]}}
{"token": ["The", "C0031727#ent", "<e1>", "the", "second", "largest", "family", "of", "mammalian", "C0387990#ent", "<e2>", "are", "distinguished", "by", "the", "presence", "of", "distinct", "proline-rich", "regions", "pleckstrin", "homology", "domains", "are", "required", "for", "proper", "regulation", "and", "activation", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0387990", "name": "C0387990#ent", "pos": [9, 10]}}
{"token": ["C0055147#ent", "<e1>", "was", "significantly", "better", "in", "controlling", "symptoms", "of", "C0042109#ent", "<e2>", "placebo", "."], "h": {"id": "C0055147", "name": "C0055147#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [9, 10]}}
{"token": ["From", "these", "observations", ",", "we", "conclude", "that", "cys2", "-", "1", "(", "C0086649#ent", "<e1>", "accompanies", "a", "very", "closely", "linked", "mutation", "that", "causes", "C0019880#ent", "<e2>", "that", "these", "mutations", "together", "confer", "cysteine", "dependence"], "h": {"id": "C0086649", "name": "C0086649#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [21, 22]}}
{"token": ["C0078956#ent", "<e1>", "treatment", "increased", "phosphorylated", "ERK", "MAP", "kinase", ",", "but", "not", "C0257535#ent", "<e2>"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [11, 12]}}
{"token": ["Overall", ",", "our", "data", "suggest", "that", "abrogation", "of", "BPDE-induced", "p53", "response", "and", "of", "NFkappaB", "activation", "C0078956#ent", "<e1>", "is", "mediated", "by", "impairment", "of", "the", "signaling", "pathway", "C0257535#ent", "<e2>"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [25, 26]}}
{"token": ["A", "half", "proportion", "of", "patients", "with", "rapidly", "C0221239#ent", "<e1>", "RPGN", ")", ",", "chronic", "focal", "glomerulonephritis", "CFGN", ")", ",", "idiopathic", "membranous", "glomerulonephritis", "C0017665#ent", "<e2>", ")", "."], "h": {"id": "C0221239", "name": "C0221239#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017665", "name": "C0017665#ent", "pos": [21, 22]}}
{"token": ["Human", "immunodeficiency", "virus", "C0017661#ent", "<e1>", "(", "HIVAN", ")", "and", "other", "glomerular", "lesions", "e.g.", ",", "C2919502#ent", "<e2>", "immune", "complex", "glomerulonephritis", "are", "frequent", "complications", "of", "HIV", "infection"], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C2919502", "name": "C2919502#ent", "pos": [14, 15]}}
{"token": ["Clinical", "signs", "C0149871#ent", "<e1>", "the", "calf", "in", "C0029896#ent", "<e2>", "of", "the", "knee", "joint", "lead", "to", "a", "false", "diagnosis"], "h": {"id": "C0149871", "name": "C0149871#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [7, 8]}}
{"token": ["The", "BC2", "variable", "region", "genes", "were", "amplified", "by", "polymerase", "chain", "reaction", "PCR", ")", ",", "using", "oligonucleotide", "primers", "C1512488#ent", "<e1>", "to", "the", "framework", "sequences", "of", "mouse", "C1420224#ent", "<e2>", "and", "V", "kappa", "genes", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420224", "name": "C1420224#ent", "pos": [25, 26]}}
{"token": ["C1455147#ent", "<e1>", "is", "a", "multitargeted", "kinase", "inhibitor", "BCR-ABL", ",", "SRC", ",", "C1416655#ent", "<e2>", ",", "PDGFRs", ",", "and", "ephrin", "A", "receptor", "kinases"], "h": {"id": "C1455147", "name": "C1455147#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [11, 12]}}
{"token": ["Because", "of", "the", "dangers", "of", "hyperkalaemic", "cardiac", "arrest", "C0038627#ent", "<e1>", "administration", "in", "children", "with", "unrecognised", "C0162674#ent", "<e2>", "there", "have", "now", "been", "moves", "to", "limit", "the", "use", "of", "this", "drug", "in", "children", "."], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [15, 16]}}
{"token": ["In", "earlier", "reports", "of", "rhabdomyolysis", "after", "general", "anaesthesia", "halothane", "and", "C0038627#ent", "<e1>", "almost", "all", "the", "patients", "had", "malignant", "hyperthermia", "MH", ")", "or", "C0162674#ent", "<e2>"], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [22, 23]}}
{"token": ["Because", "of", "the", "dangers", "of", "hyperkalemic", "cardiac", "arrest", "C0038627#ent", "<e1>", "administration", "in", "children", "with", "unrecognised", "C0162674#ent", "<e2>", "there", "have", "now", "been", "moves", "to", "limit", "the", "use", "of", "this", "drug", "in", "children", "."], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [15, 16]}}
{"token": ["Sf9", "cells", "Spodoptora", "frugidiperda", ")", "inoculated", "with", "AcNPV-NS1", "producing", "recombinant", "nonstructural", "protein", "rNS1", ")", "and", "AcNPV-VP2", "producing", "C0034861#ent", "<e1>", "rVP2", ")", "were", "used", "in", "C1426839#ent", "<e2>", "and", "ELISA", "to", "analyse", "serum", "antibodies"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1426839", "name": "C1426839#ent", "pos": [24, 25]}}
{"token": ["C0004147#ent", "<e1>", "significantly", "reduced", "MBF", "compared", "with", "placebo", ",", "C0026289#ent", "<e2>", "and", "labetalol", "."], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026289", "name": "C0026289#ent", "pos": [9, 10]}}
{"token": ["A", "patient", "with", "progressive", "supranuclear", "palsy", "C1537379#ent", "<e1>", ")", "showing", "severe", "C0085623#ent", "<e2>", ",", "postural", "instability", "gait", "disturbance", "frozen", "gait", "was", "treated", "with", "amitriptyline", "(", "30", "mg/day", ")", "."], "h": {"id": "C1537379", "name": "C1537379#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085623", "name": "C0085623#ent", "pos": [11, 12]}}
{"token": ["Scatchard", "analysis", "of", "the", "binding", "of", "125I-AII", "to", "particulates", "from", "adrenal", "C0015644#ent", "<e1>", "the", "presence", "of", "a", "single", "class", "binding", "sites", "C1839259#ent", "<e2>", "=", "0.6", "X", "10(-8", ")", "M", ")", "."], "h": {"id": "C0015644", "name": "C0015644#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [21, 22]}}
{"token": ["Both", "C0086376#ent", "<e1>", "have", "been", "reported", "to", "interact", "with", "the", "C0052128#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0052128", "name": "C0052128#ent", "pos": [10, 11]}}
{"token": ["The", "binding", "of", "C0906566#ent", "<e1>", "to", "the", "membrane-bound", "ATPase", "to", "the", "loss", "of", "the", "C1418370#ent", "<e2>", "to", "trypsin", "despite", "the", "delta", "mu", "H+", "generation", "."], "h": {"id": "C0906566", "name": "C0906566#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418370", "name": "C1418370#ent", "pos": [14, 15]}}
{"token": ["Grave's", "disease", "cause", "either", "fetal", "or", "neonatal", "C0020550#ent", "<e1>", "due", "to", "a", "transplacental", "transfer", "thyroid", "stimulating", "immunoglobulins", "C0020676#ent", "<e2>", "secondary", "to", "use", "of", "too", "large", "doses", "of", "synthetic", "antithyroid", "products", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [17, 18]}}
{"token": ["The", "tissue", "levels", "inositol", "1,4,5-trisphosphate", "isoform", "were", "found", "to", "be", "significantly", "higher", "in", "C0020550#ent", "<e1>", "hearts", "and", "lower", "in", "C0020676#ent", "<e2>", "hearts", "than", "in", "euthyroid", "ones", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [19, 20]}}
{"token": ["There", "is", "also", "emerging", "evidence", "about", "the", "efficacy", "of", "the", "novel", "antidepressant", "venlafaxine", "and", "also", "optimism", "for", "the", "potential", "utility", "of", "C0068485#ent", "<e1>", "and", "possibly", "C0085208#ent", "<e2>", "."], "h": {"id": "C0068485", "name": "C0068485#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0085208", "name": "C0085208#ent", "pos": [25, 26]}}
{"token": ["Because", "the", "gluconeogenic", "pathway", "contributes", "to", "the", "fasting", "hyperglycemia", "of", "C0011854#ent", "<e1>", "inhibitors", "of", "C0031644#ent", "<e2>", "may", "be", "useful", "in", "the", "treatment", "of", "diabetes", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [14, 15]}}
{"token": ["Several", "candidate", "genes", "C0011854#ent", "<e1>", "NIDDM", ")", "map", "on", "chromosome", "20", "including", "the", "C0031644#ent", "<e2>", "PCK1", ")", "and", "one", "of", "the", "maturity", "onset", "diabetes", "of", "the", "young", "genes", "(", "MODY1", ")", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [13, 14]}}
{"token": ["Benzo(a)pyrene", "(", "C1822725#ent", "<e1>", ")", "and", "related", "aromatic", "hydrocarbons", "suspected", "C0085169#ent", "<e2>", ";", "however", ",", "the", "molecular", "basis", "underlying", "tumorigenesis", "remains", "unclear", "."], "h": {"id": "C1822725", "name": "C1822725#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085169", "name": "C0085169#ent", "pos": [10, 11]}}
{"token": ["We", "show", "that", "C1334875#ent", "<e1>", "can", "function", "as", "an", "C0077678#ent", "<e2>", "activate", "monoubiquitination", "in", "vitro", "Jagged1", ",", "but", "not", "other", "mammalian", "Notch", "ligands"], "h": {"id": "C1334875", "name": "C1334875#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [9, 10]}}
{"token": ["Whether", "human", "C0026027#ent", "<e1>", "one", "of", "the", "main", "members", "of", "the", "C1134446#ent", "<e2>", "--", "is", "expressed", "in", "neoplasia", "of", "the", "liver", "has", "been", "the", "subject", "of", "a", "controversial", "discussion", "."], "h": {"id": "C0026027", "name": "C0026027#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "clofibrate", "and", "DEHP", "induce", "both", "cytosolic", "and", "C0026027#ent", "<e1>", "not", "the", "C1134446#ent", "<e2>", "the", "mitochondrial", "fraction"], "h": {"id": "C0026027", "name": "C0026027#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [15, 16]}}
{"token": ["Recent", "evidence", "suggests", "that", "C1423716#ent", "<e1>", "activation", "of", "C0089795#ent", "<e2>", "PLC", ")", "and", "PI-dependent", "calcium", "mobilization", "neither", "sufficient", "nor", "necessary", "to", "stimulate", "human", "ASM", "proliferation", "."], "h": {"id": "C1423716", "name": "C1423716#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0089795", "name": "C0089795#ent", "pos": [8, 9]}}
{"token": ["This", "mutation", "provides", "molecular", "confirmation", "some", "forms", "of", "C0014544#ent", "<e1>", "are", "the", "result", "of", "C2713546#ent", "<e2>", "in", "mitochondrial", "energy", "production"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", "we", "quantified", "maternal", "behavior", "C0014544#ent", "<e1>", "rats", "with", "C2713546#ent", "<e2>", "in", "the", "DA", "system", "to", "be", "involved", "in", "maternal", "behavior", "order", "to", "assess", "whether", "these", "rats", "have", "disturbances", "in", "maternal", "care"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [11, 12]}}
{"token": ["A", "21-", "year-old", "lady", "presented", "with", "chyluria", ",", "severe", "C0022806#ent", "<e1>", ",", "secondary", "amenorrhea", "profound", "hypoalbuminemia", ",", "heavy", "proteinuria", "renal", "tubular", "abnormalities", "of", "C0376185#ent", "<e2>"], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0376185", "name": "C0376185#ent", "pos": [23, 24]}}
{"token": ["The", "results", "are", "indicative", "of", "C0379199#ent", "<e1>", "as", "an", "option", "for", "secondary", "prevention", "C0029458#ent", "<e2>", "but", "longer-term", "phase", "III", "trials", "be", "performed", "before", "C0379199#ent", "<e1>", "can", "be", "recommended", "for", "this", "indication", "."], "h": {"id": "C0029458", "name": "C0029458#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0379199", "name": "C0379199#ent", "pos": [5, 6]}}
{"token": ["The", "entire", "CpACBP1", "ORF", "was", "engineered", "into", "a", "C1414855#ent", "<e1>", "expressed", "as", "a", "C0034861#ent", "<e2>", "functional", "analysis"], "h": {"id": "C1414855", "name": "C1414855#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [13, 14]}}
{"token": ["The", "therapeutical", "options", "dictated", "by", "the", "severity", "of", "the", "C0039082#ent", "<e1>", ":", "substitution", "therapy", "treatment", "of", "the", "underlying", "C0015397#ent", "<e2>", "modifying", "of", "the", "environmental", "conditions", "treatment", "of", "the", "complications", "in", "the", "most", "severe", "cases", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [18, 19]}}
{"token": ["A", "case", "of", "C0039082#ent", "<e1>", "associated", "with", "blindness", "due", "to", "C0015397#ent", "<e2>", "a", "posterior", "parasagittal", "meningioma", "reported", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [10, 11]}}
{"token": ["The", "results", "of", "this", "study", "indicate", "that", "a", "1-year", "treatment", "with", "recombinant", "interferon", "alfa-2b", "patients", "with", "non-A", ",", "C0019196#ent", "<e1>", "very", "effective", "at", "normalizing", "or", "improving", "C0002484#ent", "<e2>", "liver", "histology"], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002484", "name": "C0002484#ent", "pos": [26, 27]}}
{"token": ["These", "findings", "suggest", "that", "EAE", "and", "FA", "may", "be", "beneficial", "for", "treatment", "of", "type", "2", "diabetes", "they", "regulate", "blood", "glucose", "by", "elevating", "C0017713#ent", "<e1>", "activity", "and", "production", "of", "C0002245#ent", "<e2>", "in", "the", "liver", "."], "h": {"id": "C0017713", "name": "C0017713#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [28, 29]}}
{"token": ["C0017713#ent", "<e1>", "activity", "and", "C0002245#ent", "<e2>", "content", "were", "reduced", "whereas", "lactate", "dehydrogenase", "activity", "enhanced", "."], "h": {"id": "C0017713", "name": "C0017713#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [4, 5]}}
{"token": ["We", "report", "such", "a", "case", "in", "a", "woman", "admitted", "with", "C0034155#ent", "<e1>", "in", "whom", "C0019693#ent", "<e2>", "seropositivity", "was", "found", "."], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [14, 15]}}
{"token": ["The", "formation", "of", "C0010763#ent", "<e1>", "(", "NDMA", ")", "by", "the", "nitrosation", "of", "dimethylamine", "(", "C0301360#ent", "<e2>", ")", "is", "greatly", "enhanced", "by", "the", "presence", "of", "free", "chlorine", "HOCl", ")", "."], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0301360", "name": "C0301360#ent", "pos": [14, 15]}}
{"token": ["In", "particular", ",", "skin", "or", "C0018500#ent", "<e1>", "general", "symptoms", "as", "loss", "of", "appetite", "loss", "of", "weight", "fever", ",", "and", "C0018681#ent", "<e2>", "were", "more", "prevalent", "among", "these", "patients", "."], "h": {"id": "C0018500", "name": "C0018500#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [19, 20]}}
{"token": ["Of", "a", "series", "of", "signaling", "molecules", "known", "to", "bind", "to", "wild-type", "C1704843#ent", "<e1>", ",", "only", "phospholipase-Cgamma", "(", "PLCgamma", ")", "associated", "with", "C3274722#ent", "<e2>", "."], "h": {"id": "C1704843", "name": "C1704843#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3274722", "name": "C3274722#ent", "pos": [21, 22]}}
{"token": ["These", "results", "further", "support", "the", "theory", "that", "decreases", "in", "capacity", "of", "the", "endothelium", "to", "synthesize", "or", "release", "C1425284#ent", "<e1>", "may", "occur", "in", "long-term", "C1539862#ent", "<e2>", "diabetic", "rats", "."], "h": {"id": "C1425284", "name": "C1425284#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1539862", "name": "C1539862#ent", "pos": [23, 24]}}
{"token": ["These", "results", "define", "a", "new", "role", "for", "C1417010#ent", "<e1>", "in", "B-Raf", "activation", ",", "C1370600#ent", "<e2>", "signaling", "and", "cell", "proliferation"], "h": {"id": "C1417010", "name": "C1417010#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "C1428063#ent", "<e1>", "mutant", ",", "but", "not", "the", "C0038418#ent", "<e2>", "displayed", "a", "partial", "loss", "in", "resistance", "to", "phagocytosis", "in", "vitro"], "h": {"id": "C1428063", "name": "C1428063#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038418", "name": "C0038418#ent", "pos": [10, 11]}}
{"token": ["b", ")", "Regardless", "of", "sex", "or", "castration", ",", "fasting", "significantly", "reduces", "C0021246#ent", "<e1>", "toxicity", "in", "C1422315#ent", "<e2>", "fed", "animals", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422315", "name": "C1422315#ent", "pos": [15, 16]}}
{"token": ["Halcinoide", "was", "found", "to", "be", "superior", "in", "the", "treatment", "of", "C0033860#ent", "<e1>", "and", "equally", "effective", "as", "C0750848#ent", "<e2>", "the", "treatment", "of", "atopic", "dermatitis"], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0750848", "name": "C0750848#ent", "pos": [16, 17]}}
{"token": ["Drugs", "known", "to", "be", "topically", "active", "in", "C0033860#ent", "<e1>", ",", "eg", ",", "thiotepa", ",", "fluorouracil", ",", "and", "C0750848#ent", "<e2>", "were", "easily", "detected", "in", "the", "clinical", "protocol", "confirming", "the", "validity", "of", "this", "topical", "drug", "screening", "program"], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0750848", "name": "C0750848#ent", "pos": [17, 18]}}
{"token": ["Cyclin", "D1", "C3889128#ent", "<e1>", ")", "is", "another", "C0029016#ent", "<e2>", "that", "drives", "cell", "cycle", "progression", ";", "it", "acts", "as", "a", "growth", "factor", "to", "integrate", "extracellular", "signals", "the", "cell", "cycle", "machinery", "though", "it", "may", "also", "promote", "apoptosis", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "IL-15", ",", "though", "not", "C0879590#ent", "<e1>", ",", "is", "capable", "of", "inducing", "the", "expression", "of", "C1418887#ent", "<e2>", "and", "granzymes", "in", "pregnant", "uterine", "tissues", "explanted", "in", "vitro"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", "to", "the", "Th1", "C0879590#ent", "<e1>", "CD28RE", ",", "activity", "of", "the", "IL-4", "PRE-I", "and", "C1418887#ent", "<e2>", "can", "be", "induced", "by", "the", "CD28", "signal", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", "C0022180#ent", "<e1>", "can", "be", "employed", "safely", "and", "effectively", "as", "a", "C0003364#ent", "<e2>", "neurosurgery", "."], "h": {"id": "C0022180", "name": "C0022180#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [13, 14]}}
{"token": ["To", "examine", "the", "effect", "of", "C3887685#ent", "<e1>", "genotype", "on", "the", "pharmacokinetics", "of", "C0086303#ent", "<e2>", ",", "we", "conducted", "a", "population", "pharmacokinetic", "analysis", "the", "data", "collected", "during", "routine", "therapeutic", "drug", "of", "Japanese", "patients", "with", "supraventricular", "tachyarrhythmia"], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0086303", "name": "C0086303#ent", "pos": [12, 13]}}
{"token": ["The", "concept", "of", "neuroendocrine", "modulation", "C0277525#ent", "<e1>", "another", "dimension", "to", "the", "pathophysiology", "of", "C1290807#ent", "<e2>"], "h": {"id": "C0277525", "name": "C0277525#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1290807", "name": "C1290807#ent", "pos": [13, 14]}}
{"token": ["An", "unexpected", "finding", "revealed", "a", "non-canonical", "binding", "site", "on", "HVEM", "for", "the", "C1416372#ent", "<e1>", "B", "and", "T", "lymphocyte", "attenuator", "C1427306#ent", "<e2>", ")", ",", "and", "an", "inhibitory", "signaling", "protein", "T-cell", "activation"], "h": {"id": "C1416372", "name": "C1416372#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1427306", "name": "C1427306#ent", "pos": [19, 20]}}
{"token": ["Younger", "age", ",", "older", "age", "first", "childbirth", ",", "and", "shorter", "C2926735#ent", "<e1>", "of", "breast", "feeding", "significant", "predictors", "of", "higher", "levels", "of", "serum", "C0059875#ent", "<e2>", "levels", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0059875", "name": "C0059875#ent", "pos": [22, 23]}}
{"token": ["In", "addition", "to", "C2926735#ent", "<e1>", ",", "we", "examined", "whether", "C0059875#ent", "<e2>", "lowers", "the", "initiation", "of", "breast", "feeding"], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059875", "name": "C0059875#ent", "pos": [9, 10]}}
{"token": ["In", "this", "study", ",", "C0017337#ent", "<e1>", "encoding", "proteins", "having", "homology", "with", "the", "C1136197#ent", "<e2>", "Bacillus", "sp.", "-", "2", "were", "obtained", "from", "Bacillus", "subtilis", "ATCC6633", ",", "B.", "subtilis", "ISW1214", ",", "and", "Geobacillus", "stearotherophilus", "by", "polymerase", "chain", "reaction"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "the", "small", "effect", "C0006945#ent", "<e1>", "was", "suppressed", "by", "C0256103#ent", "<e2>", "pretreatment", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [11, 12]}}
{"token": ["A", "combination", "of", "maximal", "amounts", "of", "TSH", "or", "bromo-cAMP", "and", "C0006945#ent", "<e1>", "or", "C0256103#ent", "<e2>", "produced", "additive", "effects", "transport", ",", "while", "addition", "of", "C0256103#ent", "<e2>", "with", "C0006945#ent", "<e1>", "produced", "no", "such", "additive", "effect"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [13, 14]}}
{"token": ["We", "evaluated", "the", "effect", "of", "C0287041#ent", "<e1>", "on", "circulating", "TNFalpha", "levels", "and", "ejection", "fraction", "C0059036#ent", "<e2>", ")", "in", "patients", "with", "congestive", "heart", "failure"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [14, 15]}}
{"token": ["Subcortical", "band", "heterotopia", "C1848201#ent", "<e1>", ")", "comprises", "part", "of", "a", "spectrum", "of", "phenotypes", "associated", "with", "C0431375#ent", "<e2>", "LIS", ")", "."], "h": {"id": "C1848201", "name": "C1848201#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0431375", "name": "C0431375#ent", "pos": [15, 16]}}
{"token": ["Numerous", "chromaffin", "cells", "reactive", "for", "both", "C1413916#ent", "<e1>", "and", "C1418713#ent", "<e2>", "whereas", "some", "chromaffin", "cells", "reactive", "for", "only", "C1413916#ent", "<e1>", "from", "postnatal-2-day", "onwards", "."], "h": {"id": "C1418713", "name": "C1418713#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413916", "name": "C1413916#ent", "pos": [6, 7]}}
{"token": ["Similar", "to", "C1418713#ent", "<e1>", ",", "continuous", "neural", "stimulation", "both", "C1413916#ent", "<e2>", "mRNA", "and", "enzymatic", "activity"], "h": {"id": "C1418713", "name": "C1418713#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413916", "name": "C1413916#ent", "pos": [9, 10]}}
{"token": ["Oxidized", "or", "nonoxidized", "C2678065#ent", "<e1>", "then", "exposed", "to", "proteases", "of", "the", "digestive", "tract", "C0030909#ent", "<e2>", ",", "trypsin", ",", "and", "alpha-chymotrypsin", ")", "."], "h": {"id": "C2678065", "name": "C2678065#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030909", "name": "C0030909#ent", "pos": [13, 14]}}
{"token": ["Surprisingly", ",", "although", "most", "patients", "with", "anterior", "pituitary", "hypoplasia", "GH", "(", "growth", "hormone", "deficiency", ",", "C0271623#ent", "<e1>", "to", "be", "the", "most", "consistent", "C0014130#ent", "<e2>", "in", "patients", "with", "SOX2", "mutations", "."], "h": {"id": "C0271623", "name": "C0271623#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [22, 23]}}
{"token": ["We", "report", "here", "that", "two", "additional", "APOBEC3", "family", "members", "C1424925#ent", "<e1>", "and", "APOBEC3C", ",", "have", "potent", "antiviral", "activity", "simian", "immuno-deficiency", "virus", "C1416522#ent", "<e2>", ")", ",", "but", "not", "HIV-1", "."], "h": {"id": "C1424925", "name": "C1424925#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416522", "name": "C1416522#ent", "pos": [21, 22]}}
{"token": ["We", "report", "here", "that", "two", "additional", "C1424925#ent", "<e1>", "family", "members", "APOBEC3B", "and", "APOBEC3C", ",", "have", "potent", "antiviral", "activity", "simian", "immuno-deficiency", "virus", "C1416522#ent", "<e2>", ")", ",", "but", "not", "HIV-1", "."], "h": {"id": "C1424925", "name": "C1424925#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416522", "name": "C1416522#ent", "pos": [21, 22]}}
{"token": ["CSA", "protein", "with", "CSB", "protein", "with", "C1424650#ent", "<e1>", "a", "subunit", "of", "the", "human", "C1333718#ent", "<e2>"], "h": {"id": "C1424650", "name": "C1424650#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333718", "name": "C1333718#ent", "pos": [13, 14]}}
{"token": ["The", "protective", "effect", "ranitidine", "against", "C2827312#ent", "<e1>", "was", "not", "prevented", "by", "C0021246#ent", "<e2>", "or", "by", "the", "sulfhydryl", "blocker", "N-ethylmaleimide", "."], "h": {"id": "C2827312", "name": "C2827312#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [11, 12]}}
{"token": ["An", "oral", "preparation", "of", "C0057831#ent", "<e1>", "and", "paracetamol", "(", "C0622294#ent", "<e2>", ")", "was", "used", "as", "an", "alternative", "premedication", "to", "i.m", "."], "h": {"id": "C0057831", "name": "C0057831#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0622294", "name": "C0622294#ent", "pos": [9, 10]}}
{"token": ["We", "describe", "a", "sixth", "patient", "with", "this", "C0039082#ent", "<e1>", "which", "is", "characterized", "by", "C1858160#ent", "<e2>", "and", "hyperproliferation", "of", "fibroblasts", "in", "many", "tissues", "including", "skin", ",", "liver", ",", "kidney", ",", "and", "pancreas", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1858160", "name": "C1858160#ent", "pos": [13, 14]}}
{"token": ["This", "study", "evaluates", "whether", "C0025674#ent", "<e1>", "attracts", "or", "deters", "mosquitoes", "likely", "to", "oviposit", "in", "C0231617#ent", "<e2>"], "h": {"id": "C0025674", "name": "C0025674#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0231617", "name": "C0231617#ent", "pos": [14, 15]}}
{"token": ["11", ")", "C3539185#ent", "<e1>", "may", "be", "useful", "in", "the", "treatment", "of", "symptomatic", "C0010403#ent", "<e2>"], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010403", "name": "C0010403#ent", "pos": [12, 13]}}
{"token": ["Both", "nonsteroidal", "anti-inflammatory", "drugs", "NSAIDs", ")", "and", "C0033551#ent", "<e1>", "(", "COX", ")", "2-selective", "inhibitors", "such", "as", "C0538927#ent", "<e2>", "are", "being", "reported", "as", "having", "potent", "anticancer", "activity", "in", "laboratory", "models"], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [7, 8]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [16, 17]}}
{"token": ["Antibodies", "against", "S12", "and", "S14", "(", "but", "not", "against", "C1419699#ent", "<e1>", ")", "inhibited", "elongation", "factor", "1-dependent", "binding", "of", "[14C]Phe-tRNA", "to", "rat", "C0023899#ent", "<e2>", "80", "S", "ribosomes"], "h": {"id": "C1419699", "name": "C1419699#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [21, 22]}}
{"token": ["We", "have", "identified", "in", "jck", "mice", "a", "mutation", "in", "C1138216#ent", "<e1>", ",", "a", "novel", "and", "highly", "conserved", "member", "of", "the", "C0031727#ent", "<e2>"], "h": {"id": "C1138216", "name": "C1138216#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [20, 21]}}
{"token": ["The", "incidence", "of", "C0001126#ent", "<e1>", "increased", "serum", "potassium", "levels", "is", "rising", ",", "whereas", "C1704380#ent", "<e2>", "low", "serum", "potassium", "levels", "remains", "infrequent", "."], "h": {"id": "C0001126", "name": "C0001126#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C1704380", "name": "C1704380#ent", "pos": [13, 14]}}
{"token": ["Proximal", "C0001126#ent", "<e1>", "was", "twice", "as", "common", "as", "the", "C1704380#ent", "<e2>"], "h": {"id": "C0001126", "name": "C0001126#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C1704380", "name": "C1704380#ent", "pos": [9, 10]}}
{"token": ["Restoration", "of", "the", "thiol-depleted", "RBCs", "by", "externally", "applied", "C1452654#ent", "<e1>", "was", "significantly", "greater", "compared", "with", "C1622105#ent", "<e2>", "and", ",", "unlike", "C1622105#ent", "<e2>", ",", "was", "accompanied", "by", "hemoglobin", "protection", "oxidation", "."], "h": {"id": "C1452654", "name": "C1452654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [15, 16]}}
{"token": ["By", "contrast", ",", "transcripts", "of", "C1822653#ent", "<e1>", "Sgne-1", ")", "were", "scattered", "in", "C2828055#ent", "<e2>", ",", "and", "were", "co-localized", "with", "Ulex", "europaeus", "agglutinin-1", "cells", "."], "h": {"id": "C1822653", "name": "C1822653#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2828055", "name": "C2828055#ent", "pos": [12, 13]}}
{"token": ["C0494827#ent", "<e1>", "LABD", ")", "is", "an", "C0004364#ent", "<e2>", "by", "subepidermal", "blisters", "IgA", "autoantibodies", "against", "the", "epidermal", "basement", "membrane", "zone", "BMZ", ")", "of", "the", "skin", "."], "h": {"id": "C0494827", "name": "C0494827#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [6, 7]}}
{"token": ["C0494827#ent", "<e1>", "chronic", "bullous", "disease", "childhood", "are", "both", "C0004364#ent", "<e2>"], "h": {"id": "C0494827", "name": "C0494827#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [8, 9]}}
{"token": ["SLPI", "is", "an", "inhibitor", "of", "C2717971#ent", "<e1>", "as", "leukocyte", "elastase", "cathepsin", "G", "and", "C1413516#ent", "<e2>"], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413516", "name": "C1413516#ent", "pos": [13, 14]}}
{"token": ["C3828359#ent", "<e1>", "RPTP", ")", "zeta/beta", "is", "a", "C1413763#ent", "<e2>"], "h": {"id": "C3828359", "name": "C3828359#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413763", "name": "C1413763#ent", "pos": [7, 8]}}
{"token": ["Lysophosphatidylcholine", "(", "lyso-PTC", ")", "is", "formed", "by", "C3539768#ent", "<e1>", "PLA2", ")", "from", "phosphatidylcholine", "(", "C1706229#ent", "<e2>", ")", ",", "that", "is", "produced", "through", "phosphatidylethanolamine", "(", "PTE", ")", "methylation", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706229", "name": "C1706229#ent", "pos": [14, 15]}}
{"token": ["C0949691#ent", "<e1>", "a", "rare", "C0005944#ent", "<e2>", "the", "musculoskeletal", "manifestations", "alkaptonuria", "."], "h": {"id": "C0949691", "name": "C0949691#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [4, 5]}}
{"token": ["This", "condition", "is", "also", "known", "to", "occur", "in", "patients", "with", "rheumatoid", "arthritis", "C0949691#ent", "<e1>", "trauma", ",", "as", "well", "as", "inflammatory", "and", "C0005944#ent", "<e2>"], "h": {"id": "C0949691", "name": "C0949691#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [21, 22]}}
{"token": ["In", "vivo", "ZP", "is", "C0025517#ent", "<e1>", "to", "a", "chemically", "reactive", "glucuronide", "conjugate", "(", "C2985148#ent", "<e2>", ")", "which", "can", "undergo", "covalent", "adduct", "formation", "proteins", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2985148", "name": "C2985148#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "androgen", "acting", "apart", "from", "conversion", "to", "C2936882#ent", "<e1>", "is", "capable", "of", "specifically", "activating", "the", "somatotropic", "axis", "distinct", "C1366550#ent", "<e2>", "mechanisms", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366550", "name": "C1366550#ent", "pos": [20, 21]}}
{"token": ["A", "jaundice", "or", "a", "liver", "failure", "C0016952#ent", "<e1>", ",", "fructosaemia", ",", "tyrosinaemia", "type", "I", "after", "3", "weeks", ")", ",", "C1291611#ent", "<e2>", "bile", "acid", "synthesis", "defects", "."], "h": {"id": "C0016952", "name": "C0016952#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1291611", "name": "C1291611#ent", "pos": [19, 20]}}
{"token": ["In", "C2986859#ent", "<e1>", ",", "malaria", "cases", "in", "C1420815#ent", "<e2>", "and", "from", "June", "to", "September", "were", "contributed", "by", "An", "."], "h": {"id": "C2986859", "name": "C2986859#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420815", "name": "C1420815#ent", "pos": [7, 8]}}
{"token": ["Immunofluorescent", "studies", "the", "liver", "biopsy", "deposits", "of", "IgG", ",", "IgA", ",", "C1706005#ent", "<e1>", ",", "and", "C3", "in", "the", "C0267818#ent", "<e2>", "suggesting", "a", "role", "for", "damage", "by", "immune", "complexes", "typhoid", "hepatitis"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0267818", "name": "C0267818#ent", "pos": [18, 19]}}
{"token": ["The", "overall", "biochemical", "and", "anticonvulsant", "profile", "TGB", "suggests", "potential", "utility", "in", "the", "treatment", "of", "C0270846#ent", "<e1>", "as", "generalized", "clonic-tonic", "epilepsy", "GTCS", ")", ",", "photomyoclonic", "seizures", "C0393702#ent", "<e2>", "and", "complex", "partial", "epilepsy"], "h": {"id": "C0270846", "name": "C0270846#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0393702", "name": "C0393702#ent", "pos": [25, 26]}}
{"token": ["To", "study", "the", "pathophysiologic", "mechanism", "of", "C0270846#ent", "<e1>", "a", "patient", "with", "C0393702#ent", "<e2>", "early", "childhood", "ictal", "magnetoencephalography", "recorded", "and", "the", "neuronal", "pathway", "was", "analyzed", "."], "h": {"id": "C0270846", "name": "C0270846#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0393702", "name": "C0393702#ent", "pos": [11, 12]}}
{"token": ["C0270846#ent", "<e1>", "atypical", "absences", "and", "more", "rarely", ",", "C0393702#ent", "<e2>", "the", "predominating", "seizure", "types", "in", "67", "%", "of", "patients", "."], "h": {"id": "C0270846", "name": "C0270846#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0393702", "name": "C0393702#ent", "pos": [8, 9]}}
{"token": ["Three", "chronic", "prostatitis", "syndromes", "recognised", ",", "C0085696#ent", "<e1>", "CBP", ")", ",", "chronic", "nonbacterial", "prostatitis", "CNBP", ")", ",", "and", "C0240812#ent", "<e2>", "."], "h": {"id": "C0085696", "name": "C0085696#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0240812", "name": "C0240812#ent", "pos": [18, 19]}}
{"token": ["Knockdown", "of", "Akt", "and", "C1705791#ent", "<e1>", "activity", "using", "C3813591#ent", "<e2>", "PI3K", "and", "mitogen-activated", "protein", "kinase", "kinase", "MKK1", ")", "inhibitors", "enhanced", "alpha-TEA-induced", "apoptosis", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3813591", "name": "C3813591#ent", "pos": [8, 9]}}
{"token": ["A", "transient", "C0751911#ent", "<e1>", "in", "a", "15-year-old", "boy", "receiving", "high-dose", "methotrexate", "(", "C0025677#ent", "<e2>", ")", "for", "acute", "lymphoblastic", "leukemia"], "h": {"id": "C0751911", "name": "C0751911#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [12, 13]}}
{"token": ["We", "report", "a", "study", "comparing", "the", "knowledge", "and", "practice", "of", "14", "different", "professional", "groups", "the", "AHP", "and", "C1420015#ent", "<e1>", "in", "terms", "of", "C1415090#ent", "<e2>", "and", "CE", "."], "h": {"id": "C1420015", "name": "C1420015#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415090", "name": "C1415090#ent", "pos": [22, 23]}}
{"token": ["Because", "the", "carboxylate", "head", "group", "is", "translocated", "by", "UCP", ",", "and", "because", "the", "protonated", "FA", "diffuses", "across", "the", "membrane", ",", "this", "mechanism", "permits", "C3469521#ent", "<e1>", "to", "behave", "as", "regulated", "cycling", "C3179077#ent", "<e2>", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3179077", "name": "C3179077#ent", "pos": [30, 31]}}
{"token": ["Moreover", ",", "genistein", "was", "found", "to", "have", "a", "greater", "inhibitory", "effect", "NO", "production", "but", "no", "significant", "effect", "on", "C1968833#ent", "<e1>", "activity", "or", "protein", "and", "gene", "expression", "C0057090#ent", "<e2>", "and", "glycitein", "."], "h": {"id": "C1968833", "name": "C1968833#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0057090", "name": "C0057090#ent", "pos": [26, 27]}}
{"token": ["In", "vitro", "assays", "showed", "CA1", "was", "imported", "into", "isolated", "C0340861#ent", "<e1>", "(", "Pisum", "sativum", "chloroplasts", ",", "whereas", "CA2", "and", "C1413044#ent", "<e2>", "were", "not", "."], "h": {"id": "C0340861", "name": "C0340861#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413044", "name": "C1413044#ent", "pos": [19, 20]}}
{"token": ["We", "first", "identified", "the", "C1334043#ent", "<e1>", "the", "mouse", "C1705360#ent", "<e2>", "cMfh-1", ")", "gene", "based", "on", "sequence", "similarities", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [8, 9]}}
{"token": ["A", "vector", "expressing", "C1705438#ent", "<e1>", "was", "capable", "of", "increasing", "DNA", "synthesis", "rat", "C0036091#ent", "<e2>", "though", "complete", "mitosis", "was", "not", "observed", "."], "h": {"id": "C1705438", "name": "C1705438#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [12, 13]}}
{"token": ["Extreme", "loss", "of", "weight", "C0155964#ent", "<e1>", "therapy-resistant", "anemia", "a", "slight", "C0011847#ent", "<e2>", "are", "extra-cutaneous", "symptoms", "of", "this", "paraneoplastic", "syndrom"], "h": {"id": "C0155964", "name": "C0155964#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [10, 11]}}
{"token": ["Since", "1983", ",", "when", "mumps", ",", "measles", ",", "and", "rubella", "vaccination", "the", "C0014055#ent", "<e1>", "associated", "with", "microbes", ",", "the", "major", "associated", "C0035064#ent", "<e2>", "have", "been", "varicella-zoster", ",", "Mycoplasma", "pneumoniae", "and", "respiratory", "and", "enteroviruses", "."], "h": {"id": "C0014055", "name": "C0014055#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [21, 22]}}
{"token": ["It", "is", "probable", "that", "C0014055#ent", "<e1>", "caused", "by", "still", "unknown", "C0035064#ent", "<e2>", "exist", "in", "California", "."], "h": {"id": "C0014055", "name": "C0014055#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [10, 11]}}
{"token": ["C0003403#ent", "<e1>", "and", "leupeptin", "which", "are", "inhibitors", "of", "C1447694#ent", "<e2>", "and", "thiol", "proteinases", "and", "talopeptin", ",", "an", "inhibitor", "of", "metal", "proteinases", "significantly", "interrupted", "the", "removal", "of", "the", "zona", "pellucida", "expanding", "blastocysts", "."], "h": {"id": "C0003403", "name": "C0003403#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [8, 9]}}
{"token": ["The", "trypsin", "inhibitors", "4-guanidino", "benzoic", "acid", "4-tert-butylphenyl", "ester", "and", "C0003403#ent", "<e1>", "strongly", "inhibited", "the", "C1447694#ent", "<e2>", "of", "the", "recombinant", "enzyme", "but", "had", "no", "effect", "its", "Z-AALpNA", "hydrolyzing", "activity", "."], "h": {"id": "C0003403", "name": "C0003403#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [14, 15]}}
{"token": ["On", "the", "other", "hand", ",", "negative", "association", "results", "were", "observed", "at", "15q14-q21", "susceptibility", "region", "catatonia", "with", "the", "C1417679#ent", "<e1>", "encoding", "the", "zinc", "transporter", "C1420181#ent", "<e2>", ",", "the", "cholinergic", "receptor", "nicotinic", "alpha", "polypeptide", "7", "and", "the", "delta-like", "4", "Drosophila"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420181", "name": "C1420181#ent", "pos": [23, 24]}}
{"token": ["Sonication", "solubilized", "the", "two", "C4283949#ent", "<e1>", "with", "the", "matrix", "space", "marker", "C3540772#ent", "<e2>", "."], "h": {"id": "C4283949", "name": "C4283949#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [11, 12]}}
{"token": ["L-serine", "dehydratase", "EC", "4.2.1.13", ")", ",", "and", "malate", "dehydrogenase", "C4283949#ent", "<e1>", ",", "and", "of", "seven", "C3540772#ent", "<e2>", "involved", "in", "the", "TCA", "cycle", "of", "the", "usual", "aerobes", "."], "h": {"id": "C4283949", "name": "C4283949#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [15, 16]}}
{"token": ["The", "rabbits", "premedicated", "with", "clonidine", "tolerated", "C0239377#ent", "<e1>", "stimuli", "without", "reactions", "at", "lower", "C0018549#ent", "<e2>", "concentrations", "in", "arterial", "blood", "inspired", "air", "unpremedicated", "rabbits", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "IL-4-induced", "C1415975#ent", "<e1>", "synthesis", "by", "splenic", "mononuclear", "cells", "C1420258#ent", "<e2>", ")", "was", "greatly", "enhanced", "in", "the", "presence", "of", "ESC", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420258", "name": "C1420258#ent", "pos": [10, 11]}}
{"token": ["The", "most", "striking", "result", "was", "that", "the", "C3160718#ent", "<e1>", "group", "showed", "larger", "C1824810#ent", "<e2>", "effects", "overall", "than", "the", "HC", "group", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824810", "name": "C1824810#ent", "pos": [12, 13]}}
{"token": ["C1321744#ent", "<e1>", "was", "more", "active", "than", "the", "other", "C3540047#ent", "<e2>", "against", "methicillin-susceptible", "Staphylococcus", "aureus", "coagulase-negative", "staphylococci", "streptococci", ",", "and", "Enterococcus", "faecalis"], "h": {"id": "C1321744", "name": "C1321744#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540047", "name": "C3540047#ent", "pos": [8, 9]}}
{"token": ["During", "hepatic", "damage", "cytoplasmic", "isoenzyme", "s-AST", ")", "is", "found", "in", "greater", "quantities", "than", "mitochondrial", "isoenzyme", "C0684153#ent", "<e1>", ")", ",", "but", "the", "C0684153#ent", "<e1>", "level", "increases", "to", "a", "greater", "extent", "in", "C0023895#ent", "<e1>"], "h": {"id": "C0684153", "name": "C0684153#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [30, 31]}}
{"token": ["Elevated", "C0684153#ent", "<e1>", "levels", "were", "an", "independent", "risk", "for", "C0023895#ent", "<e2>"], "h": {"id": "C0684153", "name": "C0684153#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [9, 10]}}
{"token": ["Therapy", "of", "ocular", "toxocariasis", "primarily", "based", "upon", "corticosteroids", "use", ",", "when", "C0023049#ent", "<e1>", "few", "cases", "of", "common", "or", "C0040553#ent", "<e2>", "be", "treated", "by", "anthelmintics", "whose", "the", "most", "efficient", "appeared", "to", "be", "diethylcarbamazine", "."], "h": {"id": "C0023049", "name": "C0023049#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040553", "name": "C0040553#ent", "pos": [18, 19]}}
{"token": ["It", "is", "widely", "accepted", "that", "the", "major", "cause", "of", "C0023049#ent", "<e1>", "VLM", ")", "in", "man", "is", "C0040553#ent", "<e2>"], "h": {"id": "C0023049", "name": "C0023049#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040553", "name": "C0040553#ent", "pos": [16, 17]}}
{"token": ["Using", "PCR", "and", "sequencing", ",", "we", "identified", "B.", "quintana", "in", "the", "blood", "of", "a", "dog", "from", "the", "United", "States", "C1142550#ent", "<e1>", "probably", "also", "in", "the", "mitral", "valve", "a", "dog", "from", "New", "Zealand", "C0014118#ent", "<e2>", "."], "h": {"id": "C1142550", "name": "C1142550#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [32, 33]}}
{"token": ["To", "describe", "clinical", "features", "and", "outcomes", "of", "enterococcal", "left-sided", "native", "C1142550#ent", "<e1>", "to", "compare", "it", "to", "C0014118#ent", "<e2>", "caused", "by", "other", "pathogens", "."], "h": {"id": "C1142550", "name": "C1142550#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [16, 17]}}
{"token": ["C0043167#ent", "<e1>", "PTX", ";", "100", "ng/ml", ")", "as", "well", "as", "C1161352#ent", "<e2>", "(", "a", "muscarinic", "receptor", "antagonist", "1", "mM", ")", "blocked", "these", "effects", "of", "cholinomimetics", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [10, 11]}}
{"token": ["However", ",", "this", "effect", "was", "not", "blocked", "by", "either", "pre-treatment", "with", "C0043167#ent", "<e1>", "by", "including", "C1161352#ent", "<e2>", "during", "the", "entire", "experiment", "(", "including", "the", "30-min", "incubation", "without", "perfusion", ")", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [15, 16]}}
{"token": ["Two", "patients", "presented", "with", "C0011606#ent", "<e1>", "and", "had", "peripheral", "blood", "consistent", "with", "Sezary", "syndrome", "C1420041#ent", "<e2>", ")", "pattern", "and", "had", "rapidly", "progressive", "clinical", "courses"], "h": {"id": "C0011606", "name": "C0011606#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420041", "name": "C1420041#ent", "pos": [14, 15]}}
{"token": ["NFATc2", "is", "highly", "sensitive", "to", "cleavage", "by", "caspase-3", ",", "whereas", "C1417694#ent", "<e1>", "is", "only", "weakly", "sensitive", "to", "caspase-3", "or", "C1705065#ent", "<e2>", "."], "h": {"id": "C1417694", "name": "C1417694#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [19, 20]}}
{"token": ["Hallucinations", "are", "a", "common", "feature", "of", "certain", "C1285162#ent", "<e1>", "a", "risk", "of", "dementia", "such", "as", "Alzheimer's", "disease", "C0752347#ent", "<e2>", "and", "Parkinson's", "disease"], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752347", "name": "C0752347#ent", "pos": [17, 18]}}
{"token": ["Since", "similar", "putative", "CRDs", "are", "present", "in", "a", "variety", "of", "protein", "serine-threonine", "kinases", "the", "data", "suggest", "that", "the", "C1413723#ent", "<e1>", "may", "function", "as", "a", "major", "protein-protein", "interaction", "domain", "these", "C0031727#ent", "<e2>", "."], "h": {"id": "C1413723", "name": "C1413723#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [29, 30]}}
{"token": ["Glucocorticoids", "(", "GCs", ")", "are", "used", "in", "the", "treatment", "of", "C0026769#ent", "<e1>", "MS", ")", "and", "other", "C0004364#ent", "<e2>", "to", "their", "significant", "anti-inflammatory", "and", "immunosuppressive", "effects"], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [16, 17]}}
{"token": ["Multiple", "sclerosis", "C0026769#ent", "<e1>", ")", "is", "considered", "to", "be", "an", "C0004364#ent", "<e2>", "is", "directed", "either", "at", "myelin", "or", "at", "its", "cell", "of", "origin", "the", "oligodendrocytes", "(", "OL", ")", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [10, 11]}}
{"token": ["In", "mild", "C0011860#ent", "<e1>", ",", "gliclazide", ",", "tolbutamide", "or", "C0000992#ent", "<e2>", "is", "used", ",", "and", "in", "more", "severe", "C0011860#ent", "<e1>", "glibenclamide", "is", "used", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0000992", "name": "C0000992#ent", "pos": [9, 10]}}
{"token": ["The", "expression", "of", "a", "subset", "of", "mammalian", "genes", "is", "subject", "to", "parent", "of", "origin", "effects", "C0032483#ent", "<e1>", ")", ",", "most", "of", "which", "can", "be", "explained", "by", "C1708477#ent", "<e2>"], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1708477", "name": "C1708477#ent", "pos": [26, 27]}}
{"token": ["C2987364#ent", "<e1>", "PTEN", "gene", "transfer", "dephosphorylation", "of", "C1705341#ent", "<e2>", "specifically", "in", "U87MG", "cells", "but", "not", "in", "LN-229", "cells", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [7, 8]}}
{"token": ["The", "RP-", "domain", "deletion", "mutant", "also", "failed", "to", "fully", "activate", "and", "phosphorylate", "CaM-KI", ",", "but", "this", "mutant", "was", "indistinguishable", "from", "C2987364#ent", "<e1>", "CaM-KK", "for", "the", "phosphorylation", "and", "activation", "of", "C1705341#ent", "<e2>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [29, 30]}}
{"token": ["Multiple", "multicentre", "randomised", "controlled", "trials", "have", "shown", "clear", "efficacy", "of", "C0060926#ent", "<e1>", "and", "pregabalin", "for", "C0032768#ent", "<e2>", "painful", "diabetic", "neuropathy"], "h": {"id": "C0060926", "name": "C0060926#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0032768", "name": "C0032768#ent", "pos": [15, 16]}}
{"token": ["Both", "C0060926#ent", "<e1>", "and", "pregabalin", "are", "approved", "for", "the", "management", "of", "C0032768#ent", "<e2>", "PHN", ")", ",", "although", "dosing", "and", "pharmacokinetic", "differences", "between", "these", "medications", "may", "affect", "their", "use", "in", "actual", "practice"], "h": {"id": "C0060926", "name": "C0060926#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0032768", "name": "C0032768#ent", "pos": [11, 12]}}
{"token": ["It", "may", "be", "worth", "testing", "the", "effects", "of", "C0060926#ent", "<e1>", "on", "acute", "herpetic", "pain", "and", "the", "incidence", "of", "C0032768#ent", "<e2>", "human", "subjects", "."], "h": {"id": "C0060926", "name": "C0060926#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0032768", "name": "C0032768#ent", "pos": [18, 19]}}
{"token": ["PGE2", "tablets", "(", "Prostin", ")", "were", "given", "to", "109", "C0030612#ent", "<e1>", "and", "demoxytocin", "resoriblets", "(", "C0141502#ent", "<e2>", ")", "to", "84", "."], "h": {"id": "C0030612", "name": "C0030612#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0141502", "name": "C0141502#ent", "pos": [15, 16]}}
{"token": ["Mutations", "of", "the", "ATM", "and", "C1334862#ent", "<e1>", "responsible", "for", "the", "inherited", "C1705846#ent", "<e2>", "and", "Nijmegen", "Breakage", "Syndrome", "both", "of", "which", "are", "associated", "with", "predisposition", "to", "cancer", "."], "h": {"id": "C1334862", "name": "C1334862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705846", "name": "C1705846#ent", "pos": [11, 12]}}
{"token": ["These", "results", "are", "interpreted", "to", "suggest", "that", "the", "relaxant", "effect", "produced", "by", "these", "C0030512#ent", "<e1>", "are", "mediated", "predominantly", "by", "C0001644#ent", "<e2>", "that", "are", "not", "significantly", "differentiated", "into", "subtypes", "."], "h": {"id": "C0030512", "name": "C0030512#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [19, 20]}}
{"token": ["On", "a", "quantitative", "basis", "the", "molar", "dose-ratios", "of", "the", "C0030512#ent", "<e1>", "used", ",", "and", "the", "effects", "of", "C0001644#ent", "<e2>", "the", "responses", ",", "are", "similar", "in", "the", "two", "species", "."], "h": {"id": "C0030512", "name": "C0030512#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [17, 18]}}
{"token": ["In", "the", "presence", "of", "AA861", ",", "either", "H-7", "or", "C0028066#ent", "<e1>", "further", "inhibited", "the", "residual", "response", "to", "C1836945#ent", "<e2>", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1836945", "name": "C1836945#ent", "pos": [17, 18]}}
{"token": ["C0035339#ent", "<e1>", "such", "as", "adapalene", "gel", "C0288792#ent", "<e2>", "are", "considered", "first-line", "therapy", "the", "treatment", "of", "acne", "vulgaris"], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [0, 1]}, "relation": "chemical_structure_of", "t": {"id": "C0288792", "name": "C0288792#ent", "pos": [6, 7]}}
{"token": ["We", "tested", "the", "biologic", "stability", "sterility", "of", "the", "commercially", "available", "recombinant", "C0879590#ent", "<e1>", "preparation", "(", "aldesleukin", ";", "C0701339#ent", "<e2>", ",", "Chiron", ")", "under", "clinical", "conditions", "for", "up", "to", "30", "days", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0701339", "name": "C0701339#ent", "pos": [17, 18]}}
{"token": ["Utilizing", "immunocomplex", "kinase", "assays", ",", "we", "demonstrated", "that", "TCR/CD3", "ligation", "activated", "a", "C0257151#ent", "<e1>", "Raf-1", ")", "as", "well", "as", "a", "C0169101#ent", "<e2>", "MEK-1", ")", "in", "Jurkat", "but", "not", "in", "J.CaM1", "cells", "."], "h": {"id": "C0257151", "name": "C0257151#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [20, 21]}}
{"token": ["C1366480#ent", "<e1>", "induction", "by", "PRL", "in", "C1337092#ent", "<e2>", "with", "similar", "kinetics", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337092", "name": "C1337092#ent", "pos": [6, 7]}}
{"token": ["Single", "doses", "100", "C1416933#ent", "<e1>", "or", "250", "C1416933#ent", "<e1>", ")", "of", "a", "potent", "C0039614#ent", "<e1>", "toxoid", "were", "given", "to", "such", "individuals", "with", "naturally", "acquired", "antitoxin", "."], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039614", "name": "C0039614#ent", "pos": [13, 14]}}
{"token": ["The", "booster", "with", "DT", "given", "6", "to", "7", "years", "later", "contained", "8", "C1416933#ent", "<e1>", "aluminium", "adsorbed", "C0039614#ent", "<e2>", "toxoid", "."], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039614", "name": "C0039614#ent", "pos": [16, 17]}}
{"token": ["Daily", "incidence", "of", "C0149931#ent", "<e1>", "was", "significantly", "(", "p=0.045", ")", "lower", "under", "C0754647#ent", "<e2>", "than", "under", "transdermal", "oestrogens", "NS", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0754647", "name": "C0754647#ent", "pos": [12, 13]}}
{"token": ["This", "C0002726#ent", "<e1>", "resembles", "the", "so-called", "Portuguese", "form", "of", "the", "C0206247#ent", "<e2>", "except", "that", "the", "sensory", "loses", "were", "not", "dissociated", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0206247", "name": "C0206247#ent", "pos": [10, 11]}}
{"token": ["Nonsurgical", "management", "brachial", "plexus", "C0070570#ent", "<e1>", "blocks", ",", "which", "provide", "temporary", "relief", "of", "C0030193#ent", "<e2>", "allow", "for", "a", "period", "of", "spontaneous", "neurologic", "recovery", "of", "up", "to", "6", "months", "."], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [13, 14]}}
{"token": ["Placental", "and", "fetal", "liver", "triglyceride", "concentration", "and", "placental", "C1334332#ent", "<e1>", "were", "higher", "in", "rats", "fed", "C0268468#ent", "<e2>", "than", "in", "those", "fed", "CD", "."], "h": {"id": "C1334332", "name": "C1334332#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268468", "name": "C0268468#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", ",", "we", "examined", "the", "effect", "of", "CMT", "on", "the", "three", "parameters", "associated", "with", "kainic", "acid", "neurotoxicities", ";", "seizure/mortality", ",", "increased", "C0812299#ent", "<e1>", "FRA", ")", "and", "glial", "fibrillary", "acidic", "protein", "C1415042#ent", "<e2>", ")", "expression", "."], "h": {"id": "C0812299", "name": "C0812299#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1415042", "name": "C1415042#ent", "pos": [32, 33]}}
{"token": ["Therefore", ",", "this", "study", "refers", "to", "intestinal", "absorption", "disturbance", ",", "gluten", "C0007570#ent", "<e1>", "dermatitis", "herpetiformis", "colic", "diseases", "and", "also", "to", "C0268731#ent", "<e2>", ",", "immediate", "and", "delayed", "hypersensitivity", "deficiency", "polymorphonuclear", "functional", "deficiency", "."], "h": {"id": "C0007570", "name": "C0007570#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [20, 21]}}
{"token": ["It", "would", "therefore", "seem", "that", "for", "many", "C1956346#ent", "<e1>", "patients", "changes", "in", "dietary", "habits", "with", "C0033228#ent", "<e2>", "treatment", "might", "be", "one", "of", "the", "simplest", "and", "quickest", "ways", "of", "preventing", "the", "recurrence", "of", "myocardial", "infarction"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [15, 16]}}
{"token": ["A", "79-year-old", "man", "with", "atrial", "fibrillation", "C1956346#ent", "<e1>", "was", "taking", "warfarin", "(", "Coumadin", ")", "was", "converted", "to", "C0033228#ent", "<e2>", "from", "gemfibrozil", "therapy", "for", "persistently", "elevated", "triglyceride", "levels", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [17, 18]}}
{"token": ["The", "present", "study", "aimed", "to", "compare", "the", "efficacy", "for", "the", "therapy", "of", "C0017168#ent", "<e1>", "of", "C0795650#ent", "<e2>", "alone", "with", "a", "combination", "of", "C0795650#ent", "<e2>", "and", "mosapride", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0795650", "name": "C0795650#ent", "pos": [15, 16]}}
{"token": ["All", "four", "mutants", "exhibited", "an", "altered", "product", "profile", "7-hexoxycoumarin", "side-chain", "hydroxylation", ",", "whereas", "the", "stimulation", "of", "steroid", "hydroxylation", "C0053490#ent", "<e1>", "was", "similar", "to", "the", "C2987364#ent", "<e2>", "."], "h": {"id": "C0053490", "name": "C0053490#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [24, 25]}}
{"token": ["In", "this", "review", ",", "we", "will", "discuss", "non-infectious", "pulmonary", "complications", "HIV", "infection", "focusing", "on", "C0019686#ent", "<e1>", "the", "lung", ",", "C0029877#ent", "<e2>", "pulmonary", "hypertension", "the", "effect", "of", "antiretroviral", "therapy", "the", "incidence", "of", "these", "diseases", "."], "h": {"id": "C0019686", "name": "C0019686#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [19, 20]}}
{"token": ["These", "results", "demonstrate", "that", "C0771988#ent", "<e1>", "attenuates", "hippocampal", "synaptic", "impairment", "in", "murine", "C0042109#ent", "<e2>", "and", "provide", "a", "rationale", "for", "its", "use", "in", "infected", "humans", "who", "experience", "cognitive", "decline"], "h": {"id": "C0771988", "name": "C0771988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [12, 13]}}
{"token": ["The", "concept", "of", "pharmacokinetic", "enhancement", "-", "boosting", "-", "is", "not", "new", "as", "C0292818#ent", "<e1>", "has", "previously", "been", "utilised", "in", "this", "context", "with", "other", "C3273483#ent", "<e2>", "."], "h": {"id": "C0292818", "name": "C0292818#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273483", "name": "C3273483#ent", "pos": [23, 24]}}
{"token": ["C0292818#ent", "<e1>", "(", "RTV", ")", "strongly", "increases", "the", "concentrations", "of", "protease", "inhibitors", "C3273483#ent", "<e2>", ")", "in", "plasma", "in", "patients", "given", "a", "combination", "of", "RTV", "and", "another", "PI", "."], "h": {"id": "C0292818", "name": "C0292818#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273483", "name": "C3273483#ent", "pos": [12, 13]}}
{"token": ["Most", "of", "the", "C3273483#ent", "<e1>", "have", "some", "dyslipidaemic", "effect", ",", "especially", "C0292818#ent", "<e2>", "(", "alone", "or", "in", "combination", "with", "other", "C3273483#ent", "<e1>", ")", ",", "fosamprenavir", "and", "the", "novel", "PI", "tipranavir", "."], "h": {"id": "C0292818", "name": "C0292818#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3273483", "name": "C3273483#ent", "pos": [3, 4]}}
{"token": ["The", "aim", "of", "this", "work", "was", "to", "study", "immunohistochemical", "H-", "C0391764#ent", "<e1>", "distribution", "in", "duodenal", "mucosal", "cells", "of", "patients", "with", "C0018995#ent", "<e2>", "and", "of", "subjects", "with", "various", "degrees", "of", "iron", "loading"], "h": {"id": "C0391764", "name": "C0391764#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [20, 21]}}
{"token": ["Significant", "interindividual", "variability", "of", "C0031935#ent", "<e1>", "pharmacokinetics", "was", "found", "in", "both", "adults", "and", "children", "with", "C0040517#ent", "<e2>"], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [15, 16]}}
{"token": ["We", "have", "determined", "that", "C0031935#ent", "<e1>", "is", "clearly", "effective", "in", "C0040517#ent", "<e2>", "maintenance", "schizophrenia", "and", "some", "delusional", "disorders"], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [10, 11]}}
{"token": ["Previous", "studies", "have", "localized", "the", "C1333209#ent", "<e1>", "the", "same", "chromosome", "band", "demonstrated", "coamplification", "of", "C0252684#ent", "<e2>", "and", "MYCN", "in", "two", "retinoblastoma", "cell", "lines"], "h": {"id": "C1333209", "name": "C1333209#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0252684", "name": "C0252684#ent", "pos": [14, 15]}}
{"token": ["To", "test", "the", "hypothesis", "that", "there", "is", "a", "maturational", "change", "in", "C1420744#ent", "<e1>", "that", "thyroid", "hormone", "these", "changes", ",", "we", "examined", "the", "two", "known", "C1420744#ent", "<e1>", "in", "proximal", "tubules", ",", "occludin", "and", "C1413469#ent", "<e1>"], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413469", "name": "C1413469#ent", "pos": [32, 33]}}
{"token": ["C1838543#ent", "<e1>", "expressed", "in", "fibroblasts", "can", "be", "triggered", "by", "C0030946#ent", "<e2>", "produced", "by", "tumor", "cells", "and", "C1838543#ent", "<e1>", "expressed", "in", "tumor", "cells", "be", "triggered", "by", "C0030946#ent", "<e2>", "produced", "by", "fibroblasts", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1838543", "name": "C1838543#ent", "pos": [0, 1]}}
{"token": ["The", "study", "of", "the", "literature", "suggests", "that", "this", "is", "not", "rare", ",", "which", "is", "explained", "by", "pathogenetic", "reflexions", "concerning", "the", "allergic", "C2984892#ent", "<e1>", "of", "the", "C0041295#ent", "<e2>", "."], "h": {"id": "C2984892", "name": "C2984892#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0041295", "name": "C0041295#ent", "pos": [25, 26]}}
{"token": ["Formation", "of", "the", "26S", "proteasome", "the", "RC", "and", "the", "C0208355#ent", "<e1>", "about", "5", "microm", "C1705556#ent", "<e2>", "."], "h": {"id": "C0208355", "name": "C0208355#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [14, 15]}}
{"token": ["The", "plasmocid-induced", "stimulation", "of", "alpha-actinin", "loss", "at", "3", "h", ",", "when", "no", "increases", "of", "C0206235#ent", "<e1>", ",", "could", "be", "inhibited", "by", "a", "cysteine", "protease", "inhibitor", "C0116287#ent", "<e2>", "(", "E-64-c", ")", ",", "and", "EGTA", "."], "h": {"id": "C0206235", "name": "C0206235#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0116287", "name": "C0116287#ent", "pos": [25, 26]}}
{"token": ["A", "26", "year", "old", "previously", "healthy", "woman", "who", "was", "treated", "with", "C0015840#ent", "<e1>", "for", "premature", "labor", "30", "gestational", "weeks", "developed", "C0034063#ent", "<e2>", "intubation", "and", "mechanical", "ventilation"], "h": {"id": "C0015840", "name": "C0015840#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [20, 21]}}
{"token": ["These", "data", "support", "the", "suggestion", "that", "C1334481#ent", "<e1>", "is", "important", "and", "necessary", "for", "C1423716#ent", "<e2>", "SMC", "proliferation", "."], "h": {"id": "C1334481", "name": "C1334481#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423716", "name": "C1423716#ent", "pos": [13, 14]}}
{"token": ["NCI-H660", "harbors", "C1336641#ent", "<e1>", "fusion", "with", "a", "homozygous", "intronic", "deletion", "C1336641#ent", "<e1>", "and", "ERG", "."], "h": {"id": "C1336641", "name": "C1336641#ent", "pos": [2, 3]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1336641", "name": "C1336641#ent", "pos": [2, 3]}}
{"token": ["Of", "these", "isolates", ",", "1", "did", "not", "produce", "C0005244#ent", "<e1>", ",", "8", "produced", "the", "type", "B", "enzyme", "and", "15", "produced", "the", "C0011523#ent", "<e2>"], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011523", "name": "C0011523#ent", "pos": [21, 22]}}
{"token": ["The", "isolated", "enzyme", "requires", "ATP", "and", "C1333909#ent", "<e1>", "+", "for", "stimulation", "and", "represents", "a", "ubiquitin", "independent", "C0036734#ent", "<e2>", "containing", "essential", "sulphydryl", "group(s", ")", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [16, 17]}}
{"token": ["To", "examine", "the", "clinical", "effectiveness", "cost-effectiveness", "of", "newer", "antiepileptic", "drugs", "AEDs", ")", "for", "C0014544#ent", "<e1>", "in", "children", ":", "gabapentin", ",", "lamotrigine", ",", "C0377265#ent", "<e2>", ",", "oxcarbazepine", ",", "tiagabine", ",", "topiramate", "and", "vigabatrin", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0377265", "name": "C0377265#ent", "pos": [22, 23]}}
{"token": ["The", "c-Cbl-mediated", "ubiquitination", "of", "C3813581#ent", "<e1>", "targets", "the", "protein", "for", "degradation", "by", "the", "C0286330#ent", "<e2>"], "h": {"id": "C3813581", "name": "C3813581#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0286330", "name": "C0286330#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", ",", "we", "describe", "a", "protocol", "of", "DNA", "extraction", "diverse", "soils", "using", "a", "combination", "of", "heat", ",", "C0027203#ent", "<e1>", "(", "lysozyme", ")", "and", "C0061947#ent", "<e2>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0061947", "name": "C0061947#ent", "pos": [26, 27]}}
{"token": ["Interestingly", ",", "C1427861#ent", "<e1>", "is", "able", "to", "recruit", "the", "nucleosome", "remodeling", "C0019643#ent", "<e2>", "NuRD", ",", "to", "methylated", "DNA", "in", "vitro"], "h": {"id": "C1427861", "name": "C1427861#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [11, 12]}}
{"token": ["C1427861#ent", "<e1>", ",", "a", "methyl-CpG-binding", "protein", "is", "a", "component", "of", "the", "C0019643#ent", "<e2>", "HDAC", ")", "complex", "and", "plays", "a", "critical", "role", "in", "DNA", "methylation-mediated", "transcriptional", "repression", "."], "h": {"id": "C1427861", "name": "C1427861#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [11, 12]}}
{"token": ["cAMP", "inhibited", "GCDC-induced", "apoptosis", ",", "caspase", "3", "C0910167#ent", "<e1>", "activation", ",", "and", "cytochrome", "c", "in", "a", "C3714973#ent", "<e2>", "manner", "."], "h": {"id": "C0910167", "name": "C0910167#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3714973", "name": "C3714973#ent", "pos": [16, 17]}}
{"token": ["Sex-specificity", "of", "C0218171#ent", "<e1>", "expression", "is", "also", "regulated", "transcriptionally", ",", "whereas", "sex-specificity", "of", "C1378702#ent", "<e2>", "expression", "appears", "to", "be", "regulated", "by", "a", "post-transcriptional", "mechanism"], "h": {"id": "C0218171", "name": "C0218171#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1378702", "name": "C1378702#ent", "pos": [13, 14]}}
{"token": ["An", "C2917660#ent", "<e1>", "substitution", "at", "Pro-196", "of", "C1704945#ent", "<e2>", "confers", "a", "herbicide-resistance", "phenotype", "that", "can", "be", "used", "as", "a", "selectable", "marker", "in", "plant", "cells"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [7, 8]}}
{"token": ["Glyprolines", ",", "short", "proline-containing", "peptides", "(", "Pro-Gly-Pro", ",", "Pro-Gly", ",", "and", "C0061740#ent", "<e1>", ")", "in", "concentrations", "of", "10(-8)-10(-4", ")", "M", "decreased", "C3887648#ent", "<e2>", "the", "isolated", "rat", "aortic", "rings"], "h": {"id": "C0061740", "name": "C0061740#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [21, 22]}}
{"token": ["We", "feel", "that", "C0699918#ent", "<e1>", "has", "interfered", "with", "lung", "growth", "alveolar", "development", "altering", "mainly", "the", "C0013765#ent", "<e2>", "in", "the", "collagen-elastin", "network"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [15, 16]}}
{"token": ["Incubation", "of", "insoluble", "human", "C0013765#ent", "<e1>", "with", "different", "C0699918#ent", "<e2>", "revealed", "that", ",", "indeed", ",", "each", "protease", "degrades", "C0013765#ent", "<e1>", "in", "a", "preferential", "way", "giving", "rise", "to", "specific", "peptide", "patterns", "."], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [4, 5]}}
{"token": ["Exposure", "of", "the", "extracted", "C0013765#ent", "<e1>", "samples", "to", "several", "proteolytic", "enzymes", "including", "C0699918#ent", "<e2>", "confirmed", "the", "identity", "of", "the", "material", "as", "C0013765#ent", "<e1>", "."], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [4, 5]}}
{"token": ["We", "have", "previously", "demonstrated", "that", "C0011849#ent", "<e1>", "is", "associated", "with", "increase", "in", "intestinal", "C1826328#ent", "<e2>", "MTP", ")", "mRNA", "in", "both", "the", "rat", "and", "rabbit", "models", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826328", "name": "C1826328#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "CHO", "cells", "phosphatidylinositol-specific", "phospholipase", "C", "PI-PLC", ")", "did", "not", "significantly", "affect", "the", "level", "of", "HS", "expression", ",", "indicating", "that", "the", "C1415194#ent", "<e1>", "are", "not", "a", "major", "source", "of", "C2987155#ent", "<e2>", "in", "CHO", "cells"], "h": {"id": "C1415194", "name": "C1415194#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [30, 31]}}
{"token": ["C0403553#ent", "<e1>", "a", "rare", "disorder", "that", "combines", "juvenile", "nephronophthisis", "C0035334#ent", "<e2>"], "h": {"id": "C0403553", "name": "C0403553#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "we", "were", "able", "to", "localize", "to", "the", "NPHP4", "locus", "a", "new", "locus", "for", "C0403553#ent", "<e1>", "an", "NPHP", "variant", "associated", "with", "C0035334#ent", "<e2>"], "h": {"id": "C0403553", "name": "C0403553#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [23, 24]}}
{"token": ["We", "conducted", "electro-oculographic", "and", "electroretinographic", "studies", "six", "families", "with", "the", "autosomal", "recessively", "inherited", "C0403553#ent", "<e1>", "juvenile", "familial", "nephronophthisis", "medullary", "cystic", "disease", "association", "with", "C0035334#ent", "<e2>", "."], "h": {"id": "C0403553", "name": "C0403553#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [23, 24]}}
{"token": ["In", "rat", "hepatocytes", ",", "activation", "of", "phosphatidylinositol", "3-kinase", "(PI3K)/protein", "kinase", "B", "C1705341#ent", "<e1>", ")", ",", "protein", "kinase", "C", "PKC", ")", "and", "C1956003#ent", "<e2>", "PP-1", ")", "has", "been", "shown", "to", "be", "involved", "in", "the", "GLP-1-induced", "stimulation", "of", "glycogen", "synthase"], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1956003", "name": "C1956003#ent", "pos": [21, 22]}}
{"token": ["C0025376#ent", "<e1>", "is", "an", "opioid", "analgesic", "C0025517#ent", "<e2>", "in", "the", "liver", "by", "N-demethylation", "to", "normeperidine", ",", "a", "potent", "stimulant", "of", "the", "central", "nervous", "system"], "h": {"id": "C0025376", "name": "C0025376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [6, 7]}}
{"token": ["C0017349#ent", "<e1>", "MHCII", ")", "deficiency", "or", "bare", "lymphocyte", "syndrome", "C0005859#ent", "<e2>", ")", "is", "a", "severe", "immunodeficiency", "characterized", "by", "deficient", "T", "helper", "immunity", "."], "h": {"id": "C0017349", "name": "C0017349#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005859", "name": "C0005859#ent", "pos": [9, 10]}}
{"token": ["Multiple", "regression", "analysis", "that", "the", "C0669365#ent", "<e1>", "capacity", "of", "a", "clone", "to", "bind", "CAP", "and", "express", "C1424288#ent", "<e2>", "is", "directly", "correlated", "to", "its", "dexamethasone-induced", "potential", "to", "form", "mineralized", "tissue", "r", "=", "0.675", ")", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424288", "name": "C1424288#ent", "pos": [16, 17]}}
{"token": ["2T3", "cells", "carrying", "C0669365#ent", "<e1>", "active", "BMP", "receptor", "(", "caBMPR-IB", ")", "showed", "elevated", "C1424288#ent", "<e2>", "activity", "without", "hrBMP-2", ";", "this", "constitutive", "activity", "also", "suppressed", "by", "alpha1", "and", "alpha2", "integrin", "antibodies", "by", "anti-Col-I", "antibody"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1424288", "name": "C1424288#ent", "pos": [13, 14]}}
{"token": ["Analysis", "indicated", "that", "C1418479#ent", "<e1>", "was", "significantly", "more", "frequently", "observed", "in", "tuberculous", "pleurisy", "concurrent", "with", "C0041296#ent", "<e2>", "81", "%", ")", "than", "in", "the", "former", "alone", "(", "50", "%", ")", "."], "h": {"id": "C1418479", "name": "C1418479#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [15, 16]}}
{"token": ["All", "C1418776#ent", "<e1>", "are", "expressed", "in", "vascular", "cells", "they", "exert", "C0684286#ent", "<e2>", ",", "anti-inflammatory", "and", "vasculoprotective", "actions", "."], "h": {"id": "C1418776", "name": "C1418776#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0684286", "name": "C0684286#ent", "pos": [10, 11]}}
{"token": ["All", "C1418776#ent", "<e1>", "are", "expressed", "in", "vascular", "cells", "where", "they", "exhibit", "antiinflammatory", "and", "C0684286#ent", "<e2>"], "h": {"id": "C1418776", "name": "C1418776#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0684286", "name": "C0684286#ent", "pos": [13, 14]}}
{"token": ["There", "has", "been", "accumulating", "evidence", "demonstrating", "that", "activators", "for", "C1418776#ent", "<e1>", "PPARalpha", ")", "have", "antiinflammatory", ",", "C0684286#ent", "<e2>", ",", "and", "vasodilatory", "effects", "."], "h": {"id": "C1418776", "name": "C1418776#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0684286", "name": "C0684286#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "our", "results", "suggested", "that", "polymorphisms", "at", "codons", "83", "of", "hMTH1", "and", "codon", "326", "of", "C1335081#ent", "<e1>", "might", "contribute", "to", "C1705776#ent", "<e2>", "in", "a", "Chinese", "occupational", "population"], "h": {"id": "C1335081", "name": "C1335081#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705776", "name": "C1705776#ent", "pos": [21, 22]}}
{"token": ["Two", "intermediary", "kinases", "in", "a", "C0072402#ent", "<e1>", "is", "triggered", "in", "the", "response", "of", "Swiss", "3T3", "cells", "C1367721#ent", "<e2>", "EGF", ")", "have", "been", "identified", "."], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [16, 17]}}
{"token": ["Further", "studies", "on", "the", "effects", "of", "C1415467#ent", "<e1>", "on", "various", "ionic", "currents", "intracellular", "C0001477#ent", "<e2>", "transient", "are", "needed", "to", "clarify", "the", "Ca(2+)-dependent", "and", "the", "Ca(2+)-independent", "actions", "of", "C1415467#ent", "<e1>", "in", "HCA", "."], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [13, 14]}}
{"token": ["At", "pH", "7.4", "and", "in", "the", "presence", "of", "calcium", ",", "C2348113#ent", "<e1>", "retains", "40", "%", "of", "its", "C0031667#ent", "<e2>", "activity", "."], "h": {"id": "C2348113", "name": "C2348113#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [17, 18]}}
{"token": ["Taken", "collectively", ",", "the", "present", "data", "on", "C2348113#ent", "<e1>", "suggest", "that", "a", "similar", "endogenous", "C0031667#ent", "<e2>", "activity", "might", "be", "involved", "in", "the", "late", "steps", "stimulus-secretion", "coupling", "in", "the", "exocrine", "pancreas"], "h": {"id": "C2348113", "name": "C2348113#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "epilepsies", "share", "with", "depression", "the", "C2713546#ent", "<e1>", "in", "the", "feedback", "mechanism", "of", "the", "C1367469#ent", "<e2>", "proposing", "common", "pathophysiological", "features", "of", "up", "to", "now", "unknown", "nature", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [15, 16]}}
{"token": ["Dictyostelium", "and", "mouse", "Myb", "proteins", "bind", "to", "this", "region", "of", "the", "promoter", ",", "suggesting", "that", "C0026900#ent", "<e1>", "might", "regulate", "C1334523#ent", "<e2>", "negatively", "as", "it", "does", "in", "celA."], "h": {"id": "C0026900", "name": "C0026900#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334523", "name": "C1334523#ent", "pos": [19, 20]}}
{"token": ["To", "evaluate", "whether", "plasma", "von", "Willebrand", "factor", "C1336938#ent", "<e1>", ")", "levels", "are", "a", "useful", "indicator", "of", "disease", "activity", "C3898650#ent", "<e2>", "DM", ")", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3898650", "name": "C3898650#ent", "pos": [18, 19]}}
{"token": ["Ro31", "-", "8220", "(", "C3539645#ent", "<e1>", "inhibitor", ")", "inhibited", "IL-1beta-mediated", "C1417494#ent", "<e2>", "gene", "expression", "mucin", "secretion", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417494", "name": "C1417494#ent", "pos": [10, 11]}}
{"token": ["C1335208#ent", "<e1>", "also", "incorporated", "into", "the", "newly", "formed", "C0084178#ent", "<e2>", "fraction", "when", "partially", "purified", "soluble", "C1335208#ent", "<e1>", "incubated", "with", "D(-)-beta-hydroxybutyryl", "CoA", "in", "vitro"], "h": {"id": "C1335208", "name": "C1335208#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0084178", "name": "C0084178#ent", "pos": [8, 9]}}
{"token": ["The", "response", "to", "UV", ",", "TPA", ",", "or", "EPIF", "was", "inhibited", "by", "C0016299#ent", "<e1>", "but", "not", "by", "retinoic", "acid", "protease", "inhibitors", "or", "C0038838#ent", "<e2>"], "h": {"id": "C0016299", "name": "C0016299#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [22, 23]}}
{"token": ["Recently", ",", "the", "cDNAs", "for", "C0250935#ent", "<e1>", ",", "Matk", "and", "C1334485#ent", "<e2>", ",", "three", "Csk-related", "protein", "tyrosine", "kinases", ",", "have", "been", "cloned", "."], "h": {"id": "C0250935", "name": "C0250935#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334485", "name": "C1334485#ent", "pos": [10, 11]}}
{"token": ["In", "successful", "C0035305#ent", "<e1>", "intact", "cortical", "C0271408#ent", "<e2>", "is", "important", "."], "h": {"id": "C0035305", "name": "C0035305#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0271408", "name": "C0271408#ent", "pos": [6, 7]}}
{"token": ["Factors", "that", "had", "a", "statistically", "significant", "association", "with", "C0035305#ent", "<e1>", "included", "the", "degree", "of", "C0271408#ent", "<e2>", "the", "time", "of", "the", "original", "retinal", "detachment", "the", "extent", "of", "the", "original", "detachment", "."], "h": {"id": "C0035305", "name": "C0035305#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0271408", "name": "C0271408#ent", "pos": [14, 15]}}
{"token": ["Trypanosoma", "cruzi", "the", "protozoan", "parasite", "causes", "C0041234#ent", "<e1>", "does", "not", "synthesize", "sialic", "acid", "but", "expresses", "a", "C1101145#ent", "<e2>", "that", "catalyses", "the", "transfer", "of", "sialic", "acid", "host", "glycoconjugates", "to", "the", "parasite", "surface", "."], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1101145", "name": "C1101145#ent", "pos": [16, 17]}}
{"token": ["Trypanosoma", "cruzi", "the", "protozoan", "parasite", "for", "C0041234#ent", "<e1>", "expresses", "on", "its", "surface", "an", "uncommon", "membrane-bound", "sialidase", "known", "as", "C1101145#ent", "<e2>", "."], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1101145", "name": "C1101145#ent", "pos": [18, 19]}}
{"token": ["On", "digestion", "of", "human", "proteoglycan", "aggregate", "with", "C0164371#ent", "<e1>", ",", "rapid", "modification", "of", "the", "link", "C1136365#ent", "<e2>", ",", "whereas", "the", "aggregates", "from", "nonhuman", "cartilages", "showed", "incomplete", "cleavage", "of", "their", "link", "C1136365#ent", "<e2>"], "h": {"id": "C0164371", "name": "C0164371#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [15, 16]}}
{"token": ["R36a", "grown", "in", "media", "containing", "EA", "instead", "of", "CL", ",", "and", "therefore", "having", "phosphorylethanolamine", "instead", "of", "C3810569#ent", "<e1>", "in", "their", "C-polysaccharide", ",", "were", "unable", "to", "induce", "substantial", "C1418482#ent", "<e2>", "responses", "."], "h": {"id": "C3810569", "name": "C3810569#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [27, 28]}}
{"token": ["Several", "typical", "C0040615#ent", "<e1>", "chlorpromazine", ",", "thioridazine", ",", "spiperone", ",", "C0039955#ent", "<e2>", ")", "displayed", "neutral", "antagonist", "activity", "by", "reversing", "clozapine", "inverse", "agonism", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0039955", "name": "C0039955#ent", "pos": [10, 11]}}
{"token": ["8-Chloro-5-methoxy-2-morpholinomethyl-1-tetralone", "exhibits", "C0040615#ent", "<e1>", "potency", "in", "the", "C0039955#ent", "<e2>", "range", "in", "animal", "models"], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0039955", "name": "C0039955#ent", "pos": [7, 8]}}
{"token": ["We", "discuss", "fluotracen", "in", "relation", "to", "other", "C0040615#ent", "<e1>", "and", "thymoleptics", ",", "and", "we", "suggest", "that", "comparative", "studies", "C0039955#ent", "<e2>", "might", "be", "informative", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0039955", "name": "C0039955#ent", "pos": [18, 19]}}
{"token": ["Glutathione", ",", "N-acetylcysteine", ",", "and", "catalase", "did", "not", "attenuate", "C1142644#ent", "<e1>", "inhibition", "by", "C0525005#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [9, 10]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0525005", "name": "C0525005#ent", "pos": [13, 14]}}
{"token": ["In", "reconstituted", "systems", ",", "CYP2C19", "catalyzed", "C0525005#ent", "<e1>", "t-butylamide", "hydroxylation", "at", "a", "turnover", "rate", "2.2", "min(-1", ")", ",", "whereas", "CYP2C9", ",", "CYP2C8", ",", "and", "C1142644#ent", "<e2>", "were", "inactive", "toward", "C0525005#ent", "<e1>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [24, 25]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0525005", "name": "C0525005#ent", "pos": [6, 7]}}
{"token": ["The", "C1307053#ent", "<e1>", "either", "platelet-derived", "growth", "factor", "cells", "or", "from", "C0949804#ent", "<e2>", "migrates", "anomalously", "on", "gels", ",", "displays", "enhanced", "kinase", "activity", "and", "contains", "additional", "sites", "of", "tyrosine", "phosphorylation", "its", "amino-terminus", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0949804", "name": "C0949804#ent", "pos": [10, 11]}}
{"token": ["Cerebral", "autosomal", "dominant", "arteriopathy", "with", "subcortical", "infarcts", "leucoencephalopathy", "(", "CADASIL", ")", "is", "an", "inherited", "C0007774#ent", "<e1>", "adulthood", ",", "which", "is", "caused", "by", "NOTCH3", "C0678941#ent", "<e2>"], "h": {"id": "C0007774", "name": "C0007774#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0678941", "name": "C0678941#ent", "pos": [23, 24]}}
{"token": ["The", "results", "indicated", "that", "the", "SR", "pellets", "could", "be", "formulated", "for", "this", "C0027203#ent", "<e1>", "blend", "using", "both", "C0063242#ent", "<e2>", "K15", "and", "EUDRAGIT", "RSPO", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0063242", "name": "C0063242#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "there", "was", "no", "attenuation", "of", "the", "cAMP", "response", "to", "stimulation", "with", "C3813124#ent", "<e1>", "by", "pre-exposure", "to", "C3813124#ent", "<e1>", "or", "C1335796#ent", "<e1>", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335796", "name": "C1335796#ent", "pos": [22, 23]}}
{"token": ["These", "membranes", "displayed", "specific", ",", "high", "affinity", "binding", "for", "[", "125I", "]", "rat", "C3813124#ent", "<e1>", "and", "[", "125I", "]", "human", "C1335796#ent", "<e2>", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335796", "name": "C1335796#ent", "pos": [20, 21]}}
{"token": ["A", "complementary", "DNA", "clone", "an", "C0079941#ent", "<e1>", "human", "(", "h", ")", "SgII", "was", "synthesized", "by", "reverse", "transcription-polymerase", "chain", "reaction", "C0032002#ent", "<e2>"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [19, 20]}}
{"token": ["C0033740#ent", "<e1>", "one", "of", "the", "most", "important", "opportunistic", "infections", "patients", "with", "acquired", "C0021051#ent", "<e2>", "AIDS", ")", "."], "h": {"id": "C0033740", "name": "C0033740#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [12, 13]}}
{"token": ["3", ")", "ASL", "binding", "stabilizes", "the", "closed", "conformations", "of", "the", "beta-subunit", "for", "the", "C0102450#ent", "<e1>", "and", "quinonoid", "forms", "of", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C0102450", "name": "C0102450#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}}
{"token": ["Extensor", "digitorum", "longus", "C1447747#ent", "<e1>", ")", "muscles", "from", "wild", "type", "C1420709#ent", "<e2>", "mice", "were", "isolated", "and", "subjected", "to", "a", "series", "of", "in", "vitro", "incubation", "experiments", "."], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [10, 11]}}
{"token": ["Glucose", "transport", "measured", "in", "vitro", "isolated", "C1447747#ent", "<e1>", "muscles", "from", "alpha2i", "C1420709#ent", "<e2>", "mice", "."], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [11, 12]}}
{"token": ["C0028326#ent", "<e1>", "a", "clinically", "and", "genetically", "heterogeneous", "C0019247#ent", "<e2>"], "h": {"id": "C0028326", "name": "C0028326#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["C0015020#ent", "<e1>", "(", "340", "mg/m2", ")", "also", "provided", "significant", "protection", "against", "C0032310#ent", "<e2>", "and", "oesophagitis", "in", "patients", "with", "lung", "cancer", "thoracic", "irradiation", "a", "preliminary", "report", "from", "a", "phase", "III", "trial", "n", "=", "144", ")", "."], "h": {"id": "C0015020", "name": "C0015020#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032310", "name": "C0032310#ent", "pos": [11, 12]}}
{"token": ["To", "investigate", "the", "changes", "myocardial", "C3540790#ent", "<e1>", "related", "to", "glycolysis", "and", "fatty", "acid", "metabolism", "in", "C0264694#ent", "<e2>", "to", "evaluate", "the", "relationship", "between", "the", "gene", "expression", "glycolytic", "metabolism", "C3540790#ent", "<e1>", "and", "myocardial", "viability"], "h": {"id": "C0264694", "name": "C0264694#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [5, 6]}}
{"token": ["To", "explore", "the", "expression", "of", "triggering", "receptor", "expressed", "on", "myeloid", "cells", "C1425066#ent", "<e1>", ")", "mRNA", "in", "C0030305#ent", "<e2>", "AP", ")", "."], "h": {"id": "C1425066", "name": "C1425066#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [16, 17]}}
{"token": ["An", "C1334863#ent", "<e1>", "mimetic", "peptide", "C3d", ",", "partially", "reduced", "the", "C0150055#ent", "<e2>", "induced", "by", "CCI", "."], "h": {"id": "C1334863", "name": "C1334863#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0150055", "name": "C0150055#ent", "pos": [10, 11]}}
{"token": ["Comorbid", "conditions", "as", "ADHD", "should", "be", "targeted", "with", "pharmacotherapy", "known", "to", "be", "effective", ",", "such", "as", "C0304403#ent", "<e1>", "or", "newer", "agents", "such", "as", "C0076823#ent", "<e2>", "."], "h": {"id": "C0304403", "name": "C0304403#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0076823", "name": "C0076823#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "the", "C4255166#ent", "<e1>", "can", "be", "also", "caused", "by", "C0014130#ent", "<e2>"], "h": {"id": "C4255166", "name": "C4255166#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [10, 11]}}
{"token": ["The", "transcriptional", "induction", "C3272715#ent", "<e1>", "follows", "a", "rapid", "time", "course", "of", "C0206256#ent", "<e2>", "occurs", "in", "the", "absence", "of", "protein", "synthesis"], "h": {"id": "C3272715", "name": "C3272715#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0206256", "name": "C0206256#ent", "pos": [11, 12]}}
{"token": ["We", "have", "studied", "cyclic", "adenosine", "3',5'-monophosphate", "cyclic", "AMP", "concentrations", "in", "human", "peripheral", "blood", "lymphocytes", "stimulation", "with", "phytohemagglutinin", "(", "C0030779#ent", "<e1>", ")", ",", "isoproterenol", ",", "prostaglandins", ",", "and", "C0002575#ent", "<e2>", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [27, 28]}}
{"token": ["The", "exsorption", "of", "procainamide", "and", "C1417599#ent", "<e1>", "from", "blood", "into", "the", "intestinal", "lumen", "increased", "in", "C0035436#ent", "<e2>", "rats", "compared", "with", "normal", "rats", "."], "h": {"id": "C1417599", "name": "C1417599#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035436", "name": "C0035436#ent", "pos": [15, 16]}}
{"token": ["C1314936#ent", "<e1>", "is", "the", "most", "advanced", "compound", "among", "the", "cyclooxygenase-2", "(", "C1565860#ent", "<e2>", ")", "inhibitor", "drugs", "developed", "in", "our", "company", "."], "h": {"id": "C1314936", "name": "C1314936#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [11, 12]}}
{"token": ["C1314936#ent", "<e1>", "is", "the", "most", "advanced", "compound", "among", "the", "C1565860#ent", "<e2>", "(", "COX-2", ")", "inhibitor", "drugs", "developed", "in", "our", "company", "."], "h": {"id": "C1314936", "name": "C1314936#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [9, 10]}}
{"token": ["Aspergillosis", "of", "the", "CNS", "should", "be", "considered", "in", "those", "with", "clinical", "features", "of", "C0018681#ent", "<e1>", ",", "multiple", "cranial", "nerve", "palsies", "alteration", "of", "consciousness", "accompanied", "by", "C0037199#ent", "<e2>", ",", "especially", "in", "elderly", "and", "diabetic", "patients", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [25, 26]}}
{"token": ["This", "case", "exemplifies", "the", "need", "to", "consider", "C0037199#ent", "<e1>", "in", "the", "differential", "diagnosis", "severe", "C0018681#ent", "<e2>", ",", "even", "without", "the", "accompanying", "signs", "and", "symptoms", "of", "C0037199#ent", "<e1>", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [7, 8]}}
{"token": ["Permanent", "neonatal", "diabetes", "mellitus", "PNDM", ")", "is", "a", "rare", "form", "of", "C0011849#ent", "<e1>", "characterized", "by", "insulin-requiring", "C0020456#ent", "<e2>", "that", "is", "diagnosed", "within", "the", "first", "months", "of", "life", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [16, 17]}}
{"token": ["We", "hypothesize", "that", "this", "effect", "is", "reduced", "in", "the", "depancreatized", "dog", "model", "of", "C0011849#ent", "<e1>", "due", "to", "hepatic", "insulin", "resistance", "C0020456#ent", "<e2>", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [20, 21]}}
{"token": ["Rats", "treated", "in", "vivo", "different", "doses", "of", "C0050537#ent", "<e1>", "of", "tranylcypromine", ",", "two", "C1257954#ent", "<e2>", "abolished", "the", "aggregation", "differences", "between", "arterial", "and", "venous", "PRP"], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [13, 14]}}
{"token": ["The", "increases", "in", "medium", "calcium", "and", "PGE2", "were", "both", "inhibited", "completely", "by", "nontoxic", "concentrations", "4", "different", "PG", "cyclooxygenase", "inhibitors", "indomethacin", ",", "piroxicam", ",", "ibuprofen", ",", "and", "C0050537#ent", "<e1>", "but", "not", "by", "the", "C1257954#ent", "<e2>", "salicylic", "acid"], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [32, 33]}}
{"token": ["This", "recently", "introduced", "acronym", "describes", "a", "disease", "with", "C0039103#ent", "<e1>", ",", "Acne", ",", "Pustulosis", ",", "Hyperostosis", "and", "C0029400#ent", "<e2>", "."], "h": {"id": "C0039103", "name": "C0039103#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029400", "name": "C0029400#ent", "pos": [17, 18]}}
{"token": ["Factors", "associated", "with", "increased", "risk", "of", "reoperation", "were", "young", "age", ",", "male", "sex", ",", "native", "C0003504#ent", "<e1>", "previous", "aortic", "valve", "surgery", "history", "of", "C0014122#ent", "<e2>", ",", "and", "larger", "homograft", "size"], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [23, 24]}}
{"token": ["A", "35-year-old", "man", "with", "pre-existing", "rheumatic", "heart", "disease", "C0003504#ent", "<e1>", "AR", ")", "presented", "with", "intermittent", "fever", "ankle", "swelling", "clinical", "evidence", "C0014122#ent", "<e2>", "."], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [20, 21]}}
{"token": ["Integrated", "mapping", "of", "a", "developmental", "transcription", "factor", "network", "thus", "reveals", "a", "key", "role", "for", "C1414681#ent", "<e1>", "in", "patterning", "and", "initiating", "C0002893#ent", "<e2>", "signaling", "in", "the", "forebrain", "."], "h": {"id": "C1414681", "name": "C1414681#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0002893", "name": "C0002893#ent", "pos": [20, 21]}}
{"token": ["A", "third", "essential", "detail", "of", "the", "drug", "transport", "mechanism", "of", "C1418520#ent", "<e1>", "is", "the", "ratio", "of", "substrate", "molecules", "per", "C2744579#ent", "<e2>", "hydrolyzed", "."], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [19, 20]}}
{"token": ["C0001473#ent", "<e1>", "caused", "steady-state", "desensitization", "in", "DRG", "cells", "with", "an", "IC50", "of", "41", "nM.", "Recovery", "from", "desensitization", "of", "DRG", "cell", "receptors", "C0001473#ent", "<e1>", "was", "significantly", "slower", "than", "for", "any", "previously", "described", "C2987634#ent", "<e1>", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [31, 32]}}
{"token": ["Potassium", "and", "magnesium", "C2713546#ent", "<e1>", "are", "common", "in", "patients", "with", "C0018799#ent", "<e2>"], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [10, 11]}}
{"token": ["These", "C2713546#ent", "<e1>", "induce", "the", "inhibition", "of", "copper-enzymes", "determining", "mainly", "C0018799#ent", "<e2>", "of", "hair", "pigmentation", "reproduction", "and", "hematopoiesis", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", "we", "compared", "the", "prevalence", "of", "enamel", "defects", "recurrent", "aphthous", "stomatitis", "C0034678#ent", "<e1>", ")", "between", "patients", "diagnosed", "with", "C0007570#ent", "<e2>", "healthy", "controls"], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [20, 21]}}
{"token": ["C1413774#ent", "<e1>", "treatment", "decreased", "cellular", "cathepsin", "B", "activity", "HSV-1", "infection", ",", "suggesting", "that", "C1332804#ent", "<e2>", "involved", "in", "virus-induced", "apoptosis"], "h": {"id": "C1413774", "name": "C1413774#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [13, 14]}}
{"token": ["In", "chloralose-anaesthesized", "cats", ",", "clonidine", ",", "an", "alpha", "2-adrenoceptor", "C2987634#ent", "<e1>", "with", "an", "C0040263#ent", "<e2>", "depressed", "pudendal", "nerve", "reflex", "activity", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040263", "name": "C0040263#ent", "pos": [13, 14]}}
{"token": ["Major", "factors", "limiting", "response", "to", "C0011812#ent", "<e1>", "in", "the", "C0027404#ent", "<e2>", "physician", "prescription", "of", "sub-optimal", "drug", "dosages", "and", "a", "low", "index", "the", "limited", "therapeutic", "efficacy", "and", "frequent", "side-effects", "of", "this", "drug", "."], "h": {"id": "C0011812", "name": "C0011812#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0027404", "name": "C0027404#ent", "pos": [9, 10]}}
{"token": ["In", "all", "vertebrates", "studied", ",", "these", "C0034362#ent", "<e1>", "were", "reduced", "by", "administering", "drugs", "known", "for", "their", "C0003419#ent", "<e2>", "properties", "in", "mammals", "."], "h": {"id": "C0034362", "name": "C0034362#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [16, 17]}}
{"token": ["These", "PGE", "C0034362#ent", "<e1>", "were", "unaffected", "by", "verapamil", "pretreatment", ",", "indicating", "that", "the", "C0003419#ent", "<e2>", "action", "of", "Ca2", "+", "channel", "blockers", "before", "the", "formation", "of", "PGE", "in", "response", "to", "EP", "stimulation", "."], "h": {"id": "C0034362", "name": "C0034362#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [13, 14]}}
{"token": ["Using", "primary", "cultured", "human", "and", "rat", "hepatocytes", ",", "we", "investigated", "to", "determine", "if", "C1417826#ent", "<e1>", "is", "implicated", "in", "the", "regulation", "of", "C1704467#ent", "<e2>", "and", "Bcl-xL", ",", "two", "crucial", "apoptosis", "inhibitors", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [21, 22]}}
{"token": ["Accordingly", ",", "C1417826#ent", "<e1>", "overexpression", "in", "HepG2", "cells", "to", "C1704467#ent", "<e2>", "induction", "upon", "clotrimazole", "treatment", "protects", "cells", "against", "Fas-induced", "apoptosis"], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [9, 10]}}
{"token": ["The", "anti-apoptotic", "capacity", "of", "C1417826#ent", "<e1>", "activation", "was", "correlated", "with", "C1704467#ent", "<e2>", "and", "Bcl-xL", "induction", "at", "both", "the", "transcriptional", "and", "protein", "levels", "man", "and", "rats", ",", "respectively", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [10, 11]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "different", "C0003280#ent", "<e1>", "treatments", "may", "produce", "different", "platelet", "effects", "C1336938#ent", "<e2>", "vWf", ")", "release", "in", "unstable", "angina", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [14, 15]}}
{"token": ["Heat", "shock", "proteins", "HSP", ")", "C1415760#ent", "<e1>", "and", "gp96", "prime", "class", "I-restricted", "cytotoxic", "T", "cells", "against", "C0796126#ent", "<e2>", "present", "in", "the", "cells", "from", "which", "they", "were", "isolated", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [16, 17]}}
{"token": ["C1170000#ent", "<e1>", "binds", "to", "its", "C0003438#ent", "<e2>", ",", "protein", "S", "and", "the", "protein", "C/protein", "S", "complex", "its", "antithrombotic", "function", "inactivating", "the", "coagulation", "factors", "Va", "VIIIa", "."], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [5, 6]}}
{"token": ["Pharmacokinetic", "studies", "also", "been", "performed", "in", "C0018802#ent", "<e1>", "patients", "and", "have", "demonstrated", "that", "ER", "C0724633#ent", "<e2>", "associated", "with", "more", "pronounced", "and", "even", "beta1-blockade", "over", "a", "24-h", "period", "than", "the", "IR", "formulation"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0724633", "name": "C0724633#ent", "pos": [14, 15]}}
{"token": ["In", "the", "analysis", "of", "the", "subgroup", "of", "1,195", "patients", "with", "hypertension", "and", "C0011849#ent", "<e1>", "included", "in", "the", "LIFE", "study", "C0126174#ent", "<e2>", "had", "a", "special", "prognostic", "benefit", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [19, 20]}}
{"token": ["36", "men", "reporting", "C0037274#ent", "<e1>", "caused", "by", "dyes", "were", "diagnosed", "to", "have", "irritant", "reactions", "irritant", "C0011616#ent", "<e2>", "exacerbation", "of", "other", "C0037274#ent", "<e1>"], "h": {"id": "C0011616", "name": "C0011616#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [3, 4]}}
{"token": ["It", "most", "commonly", "presents", "as", "an", "acute", "irritant", "C0011616#ent", "<e1>", "a", "great", "number", "of", "C0037274#ent", "<e2>", "can", "manifest", "with", "lesions", "in", "the", "diaper", "area", "have", "to", "be", "considered", "in", "differential", "diagnosis"], "h": {"id": "C0011616", "name": "C0011616#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [14, 15]}}
{"token": ["The", "C0752312#ent", "<e1>", "MAPK", ")", "pathways", ",", "C1370600#ent", "<e2>", "and", "p38", ",", "were", "strongly", "activated", "by", "orexin-A.", "p38", "was", "essential", "for", "induction", "of", "cell", "death", "whereas", "the", "C1370600#ent", "<e2>", "pathway", "appeared", "protective", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [7, 8]}}
{"token": ["BDNF", "infusion", "led", "to", "rapid", "phosphorylation", "of", "the", "C0752312#ent", "<e1>", "MAP", ")", "kinases", "C1370600#ent", "<e2>", "(", "extracellular", "signal-regulated", "protein", "kinase", "and", "p38", "but", "not", "JNK", "(", "c-Jun", "N-terminal", "protein", "kinase", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [13, 14]}}
{"token": ["Decreased", "C0919336#ent", "<e1>", "activity", "is", "associated", "with", "up-regulation", "of", "tissue", "inhibitor", "C0127082#ent", "<e2>", "(", "TIMP-1", ")", "."], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [11, 12]}}
{"token": ["C0020336#ent", "<e1>", "was", "shown", "to", "bind", "with", "synaptotagmin", "(", "a", "known", "BoNT/A", "receptor", ")", "and", "C0017083#ent", "<e2>", ",", "indicating", "that", "the", "expressed", "and", "purified", "C0020336#ent", "<e1>", "protein", "retains", "a", "functionally", "active", "conformation", "."], "h": {"id": "C0017083", "name": "C0017083#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [0, 1]}}
{"token": ["In", "contrast", ",", "C1705952#ent", "<e1>", "did", "not", "further", "increase", "the", "cadmium-induced", "accumulation", "of", "C1705526#ent", "<e2>", "despite", "its", "potentiation", "effects", "on", "the", "cadmium-induced", "cell", "death", "."], "h": {"id": "C1705952", "name": "C1705952#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [13, 14]}}
{"token": ["The", "C1705526#ent", "<e1>", "wild-type", "cells", "were", "more", "sensitive", "to", "5FU", "alone", "or", "to", "C1705952#ent", "<e2>", "alone", "than", "C1705526#ent", "<e1>", "mutant-type", "cells", "."], "h": {"id": "C1705952", "name": "C1705952#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [1, 2]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "find", "out", "whether", "heteromerization", "of", "Kir2.1", "channels", "with", "wild-type", "C1416579#ent", "<e1>", "and", "Kir2.3", "channels", "contributes", "to", "the", "phenotype", "of", "C0039496#ent", "<e2>"], "h": {"id": "C1416579", "name": "C1416579#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0039496", "name": "C0039496#ent", "pos": [26, 27]}}
{"token": ["The", "recessive", "hnm1", "mutant", "C1706112#ent", "<e1>", "is", "responsible", "for", "hyper-resistance", "to", "C0025241#ent", "<e2>", "Saccharomyces", "cerevisiae"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [11, 12]}}
{"token": ["Eleven", "randomized", "trials", "C0032177#ent", "<e1>", ",", "comprising", "9,256", "patients", "with", "a", "history", "of", "transient", "C0745413#ent", "<e2>", "minor", "stroke", ",", "were", "identified", "."], "h": {"id": "C0032177", "name": "C0032177#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0745413", "name": "C0745413#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "V", "delta", "1", "+", "and", "V", "delta", "2", "+", "gamma", "delta", "T", "cells", "altered", "C1335285#ent", "<e1>", "expression", "are", "reduced", "in", "CSF", "of", "patients", "with", "established", "C0026769#ent", "<e2>", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [18, 19]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [29, 30]}}
{"token": ["A", "77", "G", "allele", "the", "gene", "encoding", "CD45", ",", "also", "known", "as", "the", "protein", "tyrosine", "phosphatase", "receptor-type", "C", "gene", "C1335285#ent", "<e1>", ")", ",", "has", "been", "associated", "with", "C0026769#ent", "<e2>", "MS", ")", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [19, 20]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [27, 28]}}
{"token": ["A", "point", "mutation", "in", "protein", "tyrosine", "phosphatase", "receptor", "type", "c", "polypeptide", "C1335285#ent", "<e1>", ")", "has", "been", "associated", "with", "C0026769#ent", "<e2>"], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}}
{"token": ["This", "study", "identified", "knowledge", "and", "concerns", "about", "avian", "C0021400#ent", "<e1>", "among", "secondary", "school", "in", "C1537404#ent", "<e2>", ",", "Saudi", "Arabia"], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1537404", "name": "C1537404#ent", "pos": [14, 15]}}
{"token": ["Hence", ",", "C1426048#ent", "<e1>", "was", "believed", "to", "form", "a", "heteromeric", "signaling", "receptor", "complex", "C1424880#ent", "<e2>", "and", "another", ",", "yet", "to", "be", "identified", ",", "cytokine", "receptor", "subunit"], "h": {"id": "C1426048", "name": "C1426048#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424880", "name": "C1424880#ent", "pos": [13, 14]}}
{"token": ["C1426048#ent", "<e1>", "inhibited", "the", "tumor", "growth", "transfectants", "expressing", "wild-type", "C1424880#ent", "<e2>", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C1426048", "name": "C1426048#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424880", "name": "C1424880#ent", "pos": [9, 10]}}
{"token": ["None", "of", "these", "alcohols", "alone", "increased", "plasma", "ALT", "or", "C1420113#ent", "<e1>", "significantly", ",", "whereas", "C3887559#ent", "<e2>", "or", "CHCl3", "administration", "to", "alcohol-treated", "animals", "resulted", "in", "significant", "elevation", "of", "plasma", "transaminases"], "h": {"id": "C1420113", "name": "C1420113#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3887559", "name": "C3887559#ent", "pos": [14, 15]}}
{"token": ["These", "data", "demonstrate", "that", "LC-1", "possesses", "C0003419#ent", "<e1>", "actions", "and", "raises", "the", "possibility", "that", "the", "C0003419#ent", "<e1>", "actions", "of", "C0011777#ent", "<e1>", "are", "mediated", "through", "the", "induction", "of", "LC-1", "."], "h": {"id": "C0003419", "name": "C0003419#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [19, 20]}}
{"token": ["Using", "splenic", "T-lymphocytes", "the", "rat", "no", "increase", "above", "control", "levels", "the", "C1704831#ent", "<e1>", "frequencies", "was", "found", "for", "C0047964#ent", "<e2>", "and", "AMMN", "for", "all", "exposure", "levels", "tested", ",", "32", "days", "after", "chemical", "exposure"], "h": {"id": "C1704831", "name": "C1704831#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0047964", "name": "C0047964#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "we", "tested", "the", "hypothesis", "that", "phosphorylation", "of", "C1453853#ent", "<e1>", "at", "536", "is", "required", "for", "C0812246#ent", "<e2>", "induced", "IkappaBalpha", "proteolysis", "that", "in", "turn", "controls", "p65", "nuclear", "translocation"], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [18, 19]}}
{"token": ["The", "transcription", "factor", "c-Jun", "the", "cAMP", "response", "element", "site", "Egr-1", "bound", "the", "Egr-1", "motif", ",", "and", "NF-kappaB", "p50", "C1453853#ent", "<e1>", "bound", "to", "the", "kappaB3", "site", "on", "the", "C0812246#ent", "<e2>"], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [27, 28]}}
{"token": ["In", "the", "OSA", "group", ",", "C1453853#ent", "<e1>", "and", "of", "monocyte", "production", "of", "tumor", "necrosis", "factor", "alpha", "C0812246#ent", "<e2>", ")", "were", "measured", "at", "the", "same", "time", "and", "after", "the", "next", "night", "continuous", "positive", "airway", "pressure", "CPAP", ")", "."], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [16, 17]}}
{"token": ["Immunolocalization", "showed", "an", "interstitial", "distribution", "of", "C1334908#ent", "<e1>", "in", "sham-operated", "kidneys", "which", "colocalized", "with", "C1336938#ent", "<e2>", "the", "presence", "of", "C1334908#ent", "<e1>", "in", "peritubular", "capillaries"], "h": {"id": "C1334908", "name": "C1334908#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [14, 15]}}
{"token": ["In", "7-day-old", "rats", ",", "C0009011#ent", "<e1>", "was", "proconvulsant", "in", "C0234535#ent", "<e2>", "it", "decreased", "the", "latency", "to", "onset", "of", "seizures", ",", "whereas", "it", "was", "anticonvulsant", "in", "25-day-old", "rats", "."], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0234535", "name": "C0234535#ent", "pos": [9, 10]}}
{"token": ["Of", "the", "C0027203#ent", "<e1>", "activities", "measured", ",", "only", "C0075485#ent", "<e2>", "glutamine", "synthetase", "and", "alcohol", "dehydrogenase", "altered", "in", "the", "ineffective", "nodules", "relative", "to", "the", "effective", "nodules", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0075485", "name": "C0075485#ent", "pos": [8, 9]}}
{"token": ["This", "response", ",", "which", "is", "referred", "to", "as", "saphenous-nerve-evoked", "slow", "ventral", "root", "potential", "(", "C1425078#ent", "<e1>", ")", ",", "was", "depressed", "by", "these", "C2936804#ent", "<e2>"], "h": {"id": "C1425078", "name": "C1425078#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2936804", "name": "C2936804#ent", "pos": [22, 23]}}
{"token": ["Although", "PDZ", "domains", "GLGF", "motifs", "of", "C0812311#ent", "<e1>", "and", "2c", "are", "identical", "to", "that", "of", "C1335624#ent", "<e2>", ",", "their", "COOH-terminal", "sequences", "from", "that", "of", "C1335624#ent", "<e2>", "."], "h": {"id": "C0812311", "name": "C0812311#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335624", "name": "C1335624#ent", "pos": [15, 16]}}
{"token": ["Choline", "acetyltransferase", "ChAT", ")", "and", "acetylcholinesterase", "(", "AChE", ")", "activity", ",", "and", "C0026454#ent", "<e1>", "concentrations", "were", "measured", "in", "the", "septum", ",", "C0001614#ent", "<e2>", "and", "hippocampus", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [21, 22]}}
{"token": ["We", "report", "the", "successful", "use", "of", "single-shot", "spinal", "anaesthesia", "for", "elective", "caesarean", "section", "in", "a", "multigravid", "woman", "with", "C0268335#ent", "<e1>", "complicated", "by", "C0026267#ent", "<e2>"], "h": {"id": "C0268335", "name": "C0268335#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0026267", "name": "C0026267#ent", "pos": [22, 23]}}
{"token": ["The", "expression", "of", "C1565860#ent", "<e1>", "in", "human", "C0332573#ent", "<e2>", "densa", "has", "not", "been", "demonstrated", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0332573", "name": "C0332573#ent", "pos": [7, 8]}}
{"token": ["We", "have", "previously", "shown", "that", "in", "renal", "cortex", "C1565860#ent", "<e1>", "expression", "is", "localized", "to", "C0332573#ent", "<e2>", "densa", "and", "surrounding", "cortical", "thick", "ascending", "limb", "of", "Henle", "(", "cTALH", ")", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0332573", "name": "C0332573#ent", "pos": [14, 15]}}
{"token": ["The", "C0050688#ent", "<e1>", "a", "broad", "affinity", "toward", "C0050690#ent", "<e2>", "C4", "to", "C18", ")", "."], "h": {"id": "C0050688", "name": "C0050688#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0050690", "name": "C0050690#ent", "pos": [7, 8]}}
{"token": ["The", "mechanisms", "of", "the", "initial", "interactions", "of", "three", "rat", "C0050688#ent", "<e1>", "short-chain", ",", "medium-chain", ",", "and", "long-chain", "acyl-CoA", "dehydrogenases", "and", "their", "C0050690#ent", "<e2>", "studied", "using", "enzyme-catalyzed", "deuterium", "exchange", "."], "h": {"id": "C0050688", "name": "C0050688#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0050690", "name": "C0050690#ent", "pos": [21, 22]}}
{"token": ["Catalepsy", "induced", "by", "C0015846#ent", "<e1>", "was", "depressed", "only", "by", "nomifensine", "and", "C0003596#ent", "<e2>", "."], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [11, 12]}}
{"token": ["C0246694#ent", "<e1>", "downregulated", "expression", "of", "X-linked", "inhibitor", "apoptosis", "protein", "C1337109#ent", "<e2>", ")", "in", "SK-Hep1", "and", "HLE", ",", "and", "of", "survivin", "in", "all", "three", "cell-types", "."], "h": {"id": "C0246694", "name": "C0246694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337109", "name": "C1337109#ent", "pos": [9, 10]}}
{"token": ["C0246694#ent", "<e1>", "downregulated", "expression", "of", "C1337109#ent", "<e2>", "apoptosis", "protein", "XIAP", ")", "in", "SK-Hep1", "and", "HLE", ",", "and", "of", "survivin", "in", "all", "three", "cell-types", "."], "h": {"id": "C0246694", "name": "C0246694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337109", "name": "C1337109#ent", "pos": [5, 6]}}
{"token": ["Asthma-like", "symptoms", ",", "infrequently", ",", "may", "be", "secondary", "to", "diseases", "like", ":", "C0017168#ent", "<e1>", "allergic", "bronchial-pulmonary", "aspergillosis", "Churg-Strauss", "syndrome", "sarcoidosis", "or", "C0024586#ent", "<e2>"], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024586", "name": "C0024586#ent", "pos": [21, 22]}}
{"token": ["5-Formyltetrahydrofolate", "(", "5-CHO-THF", ")", "is", "formed", "via", "a", "second", "catalytic", "activity", "C1420038#ent", "<e1>", "C3538858#ent", "<e2>", ")", "and", "strongly", "inhibits", "C3538858#ent", "<e2>", "and", "other", "folate-dependent", "enzymes", "in", "vitro"], "h": {"id": "C1420038", "name": "C1420038#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3538858", "name": "C3538858#ent", "pos": [13, 14]}}
{"token": ["T", "lymphocytes", "in", "thyroid", "infiltrates", "6", "patients", "with", "Hashimoto's", "thyroiditis", "HT", ")", "and", "of", "4", "patients", "with", "C0018213#ent", "<e1>", "GD", ")", "were", "analyzed", "at", "clonal", "level", "their", "profiles", "of", "C3889283#ent", "<e2>", "lymphokine", "secretion", "were", "characterized", "."], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3889283", "name": "C3889283#ent", "pos": [29, 30]}}
{"token": ["Two", "angiotensin", "converting", "enzyme", "(ACE)", "inhibitors", "trandolapril", "and", "C0014027#ent", "<e1>", ",", "were", "compared", "for", "their", "effects", "on", "rat", "food-pad", "C0013604#ent", "<e2>", "induced", "by", "carrageenin", ",", "bradykinin", ",", "dextran", "and", "platelet", "activating", "factor", "PAF", ")", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [19, 20]}}
{"token": ["C1417388#ent", "<e1>", "also", "participates", "in", "the", "patterning", "of", "the", "C1835953#ent", "<e2>", ",", "where", "it", "is", "expressed", "at", "low", "levels", "."], "h": {"id": "C1417388", "name": "C1417388#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1835953", "name": "C1835953#ent", "pos": [9, 10]}}
{"token": ["The", "recent", "identification", "of", "the", "fourth", "and", "fifth", "Parkinson's", "disease", "suggests", "multiple", "pathways-an", "impaired", "oxidative", "stress", "for", "mutations", "in", "C3541418#ent", "<e1>", ",", "and", "a", "defect", "in", "another", "signalling", "pathway", "mutations", "in", "C1417836#ent", "<e2>", "."], "h": {"id": "C3541418", "name": "C3541418#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1417836", "name": "C1417836#ent", "pos": [31, 32]}}
{"token": ["In", "this", "study", ",", "a", "comprehensive", "haplotype", "analysis", "the", "C1413348#ent", "<e1>", "which", "encodes", "C1869509#ent", "<e2>", ",", "in", "a", "Japanese", "population", "was", "conducted", "."], "h": {"id": "C1413348", "name": "C1413348#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1869509", "name": "C1869509#ent", "pos": [13, 14]}}
{"token": ["Twelve", "single", "nucleotide", "polymorphisms", "SNPs", ")", "in", "the", "human", "C1413348#ent", "<e1>", "which", "encodes", "a", "carboxylesterase", ",", "hCE-2", "[", "C1869509#ent", "<e2>", "EC", "3.1.1.1", "]", ",", "have", "been", "reported", "in", "the", "Japanese", "."], "h": {"id": "C1413348", "name": "C1413348#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1869509", "name": "C1869509#ent", "pos": [18, 19]}}
{"token": ["To", "compare", "the", "effect", "of", "combination", "therapy", "interferon-alpha", "(", "INF-alpha", ")", "and", "C1332791#ent", "<e1>", "GM-CSF", ")", "to", "monotherapy", "with", "INF-alpha", "in", "patients", "with", "C0524910#ent", "<e2>"], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0524910", "name": "C0524910#ent", "pos": [23, 24]}}
{"token": ["Again", ",", "transfection", "with", "C3853558#ent", "<e1>", ",", "an", "active", "form", "Src", ",", "could", "reverse", "C0073096#ent", "<e2>", "inhibition", "of", "VE-cadherin", "tyrosine", "phosphorylation", "and", "EC", "tube", "formation", "."], "h": {"id": "C3853558", "name": "C3853558#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0073096", "name": "C0073096#ent", "pos": [14, 15]}}
{"token": ["The", "principal", "metabolic", "pathways", "of", "C0525227#ent", "<e1>", "are", "alpha(N)-oxidation", "to", "the", "2,3-dioxobrimonidine", ",", "and", "oxidative", "cleavage", "the", "C0020924#ent", "<e2>", "5-bromo-6-guanidinoquinoxaline", "."], "h": {"id": "C0525227", "name": "C0525227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020924", "name": "C0020924#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "a", "dysfunction", "of", "C0919336#ent", "<e1>", "is", "followed", "by", "C3899480#ent", "<e2>", ",", "which", "triggers", "apoptosis", "through", "a", "mitochondrial", "pathway"], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3899480", "name": "C3899480#ent", "pos": [12, 13]}}
{"token": ["We", "have", "solved", "the", "NMR", "structure", "of", "the", "PINCH", "C1705893#ent", "<e1>", "characterized", "its", "binding", "to", "C0385469#ent", "<e2>", "."], "h": {"id": "C1705893", "name": "C1705893#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0385469", "name": "C0385469#ent", "pos": [15, 16]}}
{"token": ["The", "C1705893#ent", "<e1>", "PINCH", "interacts", "with", "C0385469#ent", "<e2>", "ILK", ")", ",", "thereby", "mediating", "focal", "adhesions", "a", "specific", "integrin/ILK", "signaling", "pathway"], "h": {"id": "C1705893", "name": "C1705893#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0385469", "name": "C0385469#ent", "pos": [6, 7]}}
{"token": ["C1424878#ent", "<e1>", "has", "homology", "with", "C1419269#ent", "<e2>", ",", "and", "the", "genes", "are", "encoded", "on", "chromosome", "5", "a", "head-to-tail", "fashion", "."], "h": {"id": "C1424878", "name": "C1424878#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419269", "name": "C1419269#ent", "pos": [5, 6]}}
{"token": ["We", "used", "clinical", "doses", "2-cyano-3-hydroxy-N-(4-trifluoromethylphenyl)-butenamide", "(", "C0100724#ent", "<e1>", ",", "which", "is", "an", "active", "metabolite", "of", "C0063041#ent", "<e2>", ",", "and", "decreased", "the", "number", "of", "viable", "human", "primary", "mast", "cells", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0100724", "name": "C0100724#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0063041", "name": "C0063041#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "effect", "of", "C0100724#ent", "<e1>", "the", "active", "metabolite", "of", "C0063041#ent", "<e2>", "-", "on", "the", "production", "of", "IL-1", "receptor", "antagonist", "IL-1Ra", ")", "by", "human", "synovial", "fibroblasts", "articular", "chondrocytes"], "h": {"id": "C0100724", "name": "C0100724#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0063041", "name": "C0063041#ent", "pos": [15, 16]}}
{"token": ["Complications", "such", "as", "bleeding", ",", "perforation", ",", "obstruction", ",", "malabsorption", ",", "diverticulitis", ",", "C0005750#ent", "<e1>", "volvulus", ",", "and", "C0021933#ent", "<e2>", "may", "warrant", "surgical", "intervention"], "h": {"id": "C0005750", "name": "C0005750#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0021933", "name": "C0021933#ent", "pos": [18, 19]}}
{"token": ["Altered", "expression", "of", "C1334501#ent", "<e1>", ",", "Pbx1", "and", "Psen2", "and", "C1384617#ent", "<e2>", "in", "MKL", "detected", "with", "oligonucleotide", "microarrays", "confirmed", "by", "qPCR", "and", "IHC", "."], "h": {"id": "C1334501", "name": "C1334501#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1384617", "name": "C1384617#ent", "pos": [10, 11]}}
{"token": ["The", "effectiveness", "of", "meconium", "screening", "C1412332#ent", "<e1>", "as", "an", "indication", "of", "C0010674#ent", "<e2>", "examined", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [11, 12]}}
{"token": ["The", "recent", "commercial", "introduction", "of", "a", "method", "for", "detecting", "C1412332#ent", "<e1>", "in", "meconium", "makes", "screening", "for", "C0010674#ent", "<e2>", "for", "many", "hospitals", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [16, 17]}}
{"token": ["These", "results", "strongly", "suggest", "that", "the", "augmentation", "of", "O2-", "generation", "in", "C0023786#ent", "<e1>", "by", "dietary", "restriction", "due", "to", "the", "increased", "activity", "of", "C0033634#ent", "<e2>", "phosphorylate", "and", "activate", "O2-generating", "enzyme", "system", "NADPH", "oxidase"], "h": {"id": "C0023786", "name": "C0023786#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [22, 23]}}
{"token": ["The", "susceptibility", "of", "humans", "to", "the", "variant", "C0022336#ent", "<e1>", "greatly", "influenced", "by", "polymorphisms", "within", "the", "human", "prion", "protein", "gene", "C1418941#ent", "<e2>", ")", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C1418941", "name": "C1418941#ent", "pos": [19, 20]}}
{"token": ["TVS", "have", "been", "found", "in", "all", "naturally", "occurring", "and", "experimentally", "induced", "TSEs", ",", "including", "variant", "C0022336#ent", "<e1>", "human", "familial", "TSEs", "--", "fatal", "C1418941#ent", "<e2>", "Gerstmann-Str\u00e4ussler-Scheinker", "disease"], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [15, 16]}, "relation": "disease_has_associated_gene", "t": {"id": "C1418941", "name": "C1418941#ent", "pos": [22, 23]}}
{"token": ["All", "infants", "with", "basal", "ganglia", "hemorrhage", "5/5", ")", "and", "C0014068#ent", "<e1>", "5/5", ")", "and", "the", "majority", "with", "C0023529#ent", "<e2>", "9/12", ")", "and", "focal", "parenchymal", "hemorrhages", "9/15", ")", "had", "developmental", "abnormalities", "discharge", "."], "h": {"id": "C0014068", "name": "C0014068#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0023529", "name": "C0023529#ent", "pos": [17, 18]}}
{"token": ["Pretreatment", "of", "cyc-", "cells", "with", "pertussis", "toxin", "C1419249#ent", "<e1>", "from", "inducing", "the", "enhancement", "of", "C0917964#ent", "<e2>", "cAMP", "accumulation", "in", "intact", "cells", "."], "h": {"id": "C1419249", "name": "C1419249#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "of", "pancreatic", "acini", "5-HT", "reduced", "the", "inhibition", "by", "the", "stable", "SS", "analogue", "C1419249#ent", "<e1>", "201", "-", "995", "of", "basal", "and", "C0917964#ent", "<e2>", "(FK)-stimulated", "adenylyl", "cyclase", "AC", ")", "activity", "in", "pancreatic", "acinar", "membranes", "."], "h": {"id": "C1419249", "name": "C1419249#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [21, 22]}}
{"token": ["The", "capacity", "of", "these", "C0033036#ent", "<e1>", "subsets", "to", "present", "soluble", "antigens", "C0026780#ent", "<e2>", ",", "tetanus", "toxoid", "was", "also", "examined", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026780", "name": "C0026780#ent", "pos": [11, 12]}}
{"token": ["After", "24", "hours", "there", "was", "a", "clear", "decrease", "of", "these", "proinflammatory", "genes", "but", "a", "remaining", "and", "increasing", "upregulation", "of", "important", "antiapoptotic", "genes", "C0033607#ent", "<e1>", ",", "and", "other", "probably", "C0033613#ent", "<e2>"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0033613", "name": "C0033613#ent", "pos": [28, 29]}}
{"token": ["This", "investigation", "examined", "the", "effectiveness", "of", "a", "C0033607#ent", "<e1>", "LEX032", ")", "when", "used", "as", "a", "C0033613#ent", "<e2>", "ischemia", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033613", "name": "C0033613#ent", "pos": [15, 16]}}
{"token": ["Storage", "of", "C1419693#ent", "<e1>", "in", "the", "presence", "of", "C4284130#ent", "<e2>", "(", "1", "mM", ")", "significantly", "increased", "the", "lifetime", "of", "the", "labile", "N6-hydroxylase", "activity"], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4284130", "name": "C4284130#ent", "pos": [8, 9]}}
{"token": ["A", "C0040073#ent", "<e1>", "a", "strong", "inhibition", "of", "the", "C0035681#ent", "<e2>", "in", "vitro"], "h": {"id": "C0040073", "name": "C0040073#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [8, 9]}}
{"token": ["Trachoma", "is", "a", "C0022573#ent", "<e1>", "caused", "by", "C0015407#ent", "<e2>", "Chlamydia", "trachomatis"], "h": {"id": "C0022573", "name": "C0022573#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015407", "name": "C0015407#ent", "pos": [7, 8]}}
{"token": ["A", "clinical", "cross-reaction", "with", "C0066922#ent", "<e1>", ",", "a", "mucopolysaccharidase", "used", "in", "C0029408#ent", "<e2>", "treatment", ",", "has", "recently", "been", "published", "."], "h": {"id": "C0066922", "name": "C0066922#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [11, 12]}}
{"token": ["Higher", "plant", "chloroplasts", "contain", "a", "21-kDa", "protein", "chaperonin", "21", "C1413857#ent", "<e1>", ")", ",", "that", "is", "a", "functional", "C1334043#ent", "<e2>", "of", "the", "chaperonin", "10", "Cpn10", ")", "."], "h": {"id": "C1413857", "name": "C1413857#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}}
{"token": ["We", "investigated", "the", "hemodynamic", "response", "and", "pharmacokinetics", "of", "C0128513#ent", "<e1>", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}}
{"token": ["This", "study", "examines", "the", "acute", "hemodynamic", "response", "to", "intravenous", "and", "C0128513#ent", "<e1>", "12", "patients", "with", "moderate", "to", "moderately", "severe", "C0018801#ent", "<e2>"], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["The", "results", "of", "this", "study", "suggest", "that", "C0040034#ent", "<e1>", "may", ",", "through", "reduction", "of", "platelet-mediated", "clumping", "of", "C2316467#ent", "<e2>", ",", "provide", "a", "protective", "mechanism", "the", "host", "during", "CM", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2316467", "name": "C2316467#ent", "pos": [17, 18]}}
{"token": ["Many", "C1456542#ent", "<e1>", "as", "Parkinson's", "disease", "Alzheimer's", "disease", "amyotrophic", "lateral", "sclerosis", "ALS", ")", ",", "C0020179#ent", "<e2>", ",", "stroke", ",", "head", "trauma", "and", "infection", ",", "are", "associated", "with", "inflammation", "that", "is", "involved", "in", "neuropathologenesis", "and", "hyperalgesis", "."], "h": {"id": "C1456542", "name": "C1456542#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020179", "name": "C0020179#ent", "pos": [14, 15]}}
{"token": ["C1419240#ent", "<e1>", "purified", "to", "near", "homogeneity", "following", "C0001622#ent", "<e2>", "in", "a", "bacterial", "expression", "system"], "h": {"id": "C1419240", "name": "C1419240#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [7, 8]}}
{"token": ["Western", "blot", "analysis", "antiserum", "to", "Escherichia", "coli", "C1419240#ent", "<e1>", "showed", "that", "C0001622#ent", "<e2>", "of", "C1419240#ent", "<e1>", "was", "correlated", "with", "overtranscription", "of", "recA", "in", "an", "S.", "ambofaciens", "amplified", "mutant", "derived", "from", "genetic", "instability"], "h": {"id": "C1419240", "name": "C1419240#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [11, 12]}}
{"token": ["Drugs", "considered", "to", "produce", "the", "most", "significant", "interactions", "with", "salicylates", "include", "anticoagulants", "and", "thrombolytic", "agents", "uricosuric", "agents", "C3539185#ent", "<e1>", ",", "methotrexate", "and", "sulphonylurea", "C0020616#ent", "<e2>"], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [23, 24]}}
{"token": ["Low", "levels", "of", "DNA", "damage", "observed", "after", "exposure", "of", "C0669372#ent", "<e1>", "to", "either", "AAF", "or", "2-aminofluorene", "(", "C4049859#ent", "<e2>", ")", "(", "50", "-", "100", "microM", ")", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [17, 18]}}
{"token": ["The", "transforming", "activity", "C0908880#ent", "<e1>", "minimally", "requires", "an", "ETS", "DNA", "binding", "domain", "the", "C0808901#ent", "<e2>", "NH(2", ")", "terminus", "."], "h": {"id": "C0908880", "name": "C0908880#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [13, 14]}}
{"token": ["Reverse", "transcriptase-PCR", "total", "tumor", "cell", "RNA", "the", "examined", "cases", "showed", "five", "types", "of", "C0908880#ent", "<e1>", "chimeric", "product", "resulting", "from", "various", "junctions", "between", "C0808901#ent", "<e2>", "exon", "7", "10", "with", "FLI1", "exon", "5", "6", ",", "or", "8", "."], "h": {"id": "C0908880", "name": "C0908880#ent", "pos": [13, 14]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [22, 23]}}
{"token": ["Mutations", "in", "PKD1", "and", "C1418600#ent", "<e1>", ",", "which", "encode", "the", "C0021699#ent", "<e2>", "PC1", ")", "and", "polycystin-2", "(", "PC2", ")", "respectively", ",", "account", "for", "almost", "all", "cases", "of", "ADPKD", "."], "h": {"id": "C1418600", "name": "C1418600#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [10, 11]}}
{"token": ["Autosomal", "dominant", "polycystic", "kidney", "disease", "ADPKD", ")", "is", "a", "prevalent", "genetic", "disorder", "caused", "by", "mutations", "in", "the", "PKD1", "and", "C1418600#ent", "<e1>", "genes", "that", "encode", "the", "C0021699#ent", "<e2>", "-2", ",", "respectively", "."], "h": {"id": "C1418600", "name": "C1418600#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [25, 26]}}
{"token": ["The", "amino", "acid", "sequence", "NADH", "CoQ", "reductase", "subunit", "IV", "highly", "C1334043#ent", "<e1>", "with", "those", "of", "enzymes", "such", "as", "ATPase", ",", "C3888272#ent", "<e2>", "adenylate", "kinase"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3888272", "name": "C3888272#ent", "pos": [20, 21]}}
{"token": ["Patients", "with", "resistance", "to", "rifampicin", "and", "C0034239#ent", "<e1>", "and", "previous", "treatment", "for", "C0041323#ent", "<e2>", "were", "excluded", "."], "h": {"id": "C0034239", "name": "C0034239#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [12, 13]}}
{"token": ["A", "direct", "plasma", "injection", "HPLC", "method", "has", "been", "developed", "for", "the", "determination", "of", "selected", "C0031436#ent", "<e1>", "(", "promethazine", ",", "promazine", ",", "C0008286#ent", "<e2>", ")", "using", "a", "Hisep", "column"], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [14, 15]}, "relation": "chemical_structure_of", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "she", "reacted", "positively", "to", "photopatch", "testing", "ultraviolet", "A", "C0031436#ent", "<e1>", "such", "as", "C0008286#ent", "<e2>", "and", "perphenazine", "."], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [11, 12]}, "relation": "chemical_structure_of", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [15, 16]}}
{"token": ["These", "results", "demonstrated", "that", "C3811127#ent", "<e1>", "could", "be", "a", "candidate", "C1516021#ent", "<e2>", "lung", "cancer"], "h": {"id": "C3811127", "name": "C3811127#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516021", "name": "C1516021#ent", "pos": [10, 11]}}
{"token": ["It", "is", "thought", "that", "the", "majority", "of", "autoimmune", "endocrinopathies", "including", "Graves'", "disease", "autoimmune", "hypothyroidism", "C0011860#ent", "<e1>", "autoimmune", "Addison's", "disease", "sporadic", "and", "as", "well", "as", "C0085859#ent", "<e2>", "are", "inherited", "as", "complex", "genetic", "traits"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085859", "name": "C0085859#ent", "pos": [24, 25]}}
{"token": ["In", "spite", "of", "the", "atypical", "Tm", "value", ",", "the", "C0015403#ent", "<e1>", "responsive", "to", "acyclovir", "and", "resolved", "after", "intravenous", "C0019340#ent", "<e2>", "given", "for", "5", "days", "."], "h": {"id": "C0015403", "name": "C0015403#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019340", "name": "C0019340#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "C4084905#ent", "<e1>", "directly", "interacted", "with", "C1333572#ent", "<e2>", "and", "phosphorylated", "it", "."], "h": {"id": "C4084905", "name": "C4084905#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333572", "name": "C1333572#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "expression", "of", "the", "dominant-negative", "auto-inhibitory", "domain", "of", "C4084905#ent", "<e1>", "(", "Pak", "amino", "acids", "-", "149", ")", "promoted", "the", "ability", "of", "C1333572#ent", "<e2>", "to", "activate", "transcription", "from", "FRE", "."], "h": {"id": "C4084905", "name": "C4084905#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333572", "name": "C1333572#ent", "pos": [23, 24]}}
{"token": ["IgA", "nephropathy", "IgAN", ")", "is", "a", "chronic", "form", "C0017658#ent", "<e1>", "which", "is", "characterized", "by", "the", "deposition", "in", "the", "glomerular", "mesangium", "C0071610#ent", "<e2>", "pIgA", ")", ",", "the", "source", "of", "which", "is", "unknown", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0071610", "name": "C0071610#ent", "pos": [20, 21]}}
{"token": ["C0017658#ent", "<e1>", "associated", "with", "macromolecules", "of", "C0071610#ent", "<e2>", "the", "circulation", "and", "mesangial", "deposits", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0071610", "name": "C0071610#ent", "pos": [6, 7]}}
{"token": ["Hemophilia", "A", "a", "C0005779#ent", "<e1>", "is", "characterized", "by", "a", "C1969443#ent", "<e2>", "the", "coagulation", "protein", "factor", "VIII"], "h": {"id": "C0005779", "name": "C0005779#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1969443", "name": "C1969443#ent", "pos": [9, 10]}}
{"token": ["Reverse", "transcriptase-polymerase", "chain", "reaction", "RT-PCR", ")", "revealed", "a", "C3274737#ent", "<e1>", "fusion", "in", "which", "exon", "13", "C1334913#ent", "<e2>", "was", "fused", "in-frame", "with", "exon", "8", "TOP1", "."], "h": {"id": "C3274737", "name": "C3274737#ent", "pos": [8, 9]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1334913", "name": "C1334913#ent", "pos": [15, 16]}}
{"token": ["Exercise-induced", "bronchoconstriction", "EIB", ")", "was", "associated", "with", "eosinophilic", "airway", "inflammation", ",", "C1334103#ent", "<e1>", "BHR", ")", ",", "atopy", "and", "C0001883#ent", "<e2>"], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [18, 19]}}
{"token": ["The", "algorithm", "consisted", "of", "five", "classes", "based", "on", "the", "presence", "or", "absence", "of", "C1334103#ent", "<e1>", "BHR", ")", ",", "respiratory", "symptoms", "smoking", ",", "C0001883#ent", "<e2>", "and", "bronchodilator", "reversibility", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [22, 23]}}
{"token": ["Airway", "remodelling", "might", "be", "responsible", "for", "most", "of", "the", "inter-individual", "variability", "of", "C1334103#ent", "<e1>", "might", "also", "determine", "the", "irreversible", "component", "of", "the", "C0001883#ent", "<e2>", "sometimes", "detectable", "in", "asthmatic", "patients", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [22, 23]}}
{"token": ["Here", ",", "we", "discuss", "the", "precise", "regulation", "of", "C0034678#ent", "<e1>", "and", "Rho", "subfamilies", "of", "C0242853#ent", "<e2>", "by", "GEFs", "and", "other", "regulatory", "proteins", "cardiac", "hypertrophy"], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [14, 15]}}
{"token": ["The", "discussion", "will", "be", "limited", "to", "inhibitors", "which", "are", "currently", "in", "human", "clinical", "trials", "and", "include", "inhibitors", "of", "C0034678#ent", "<e1>", "processing", ",", "inhibitors", "of", "C0242853#ent", "<e2>", "and", "inhibitors", "of", "downstream", "ras", "effectors", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [24, 25]}}
{"token": ["3", ")", "DO", "NOT", "START", "ALLOPURINOL", "OR", "C0033209#ent", "<e1>", "DURING", "AN", "ACUTE", "FLARE", "OF", "C0018099#ent", "<e2>", "--", "IT", "MAY", "MAKE", "THE", "EPISODE", "WORSE", "."], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [14, 15]}}
{"token": ["The", "aims", "of", "the", "study", "were", "to", "compare", "the", "prevalence", "of", "C0039841#ent", "<e1>", "alcohol-", "and", "hepatitis", "C", "virus-(HCV-", ")", "related", "C1623038#ent", "<e2>", "and", "in", "patients", "with", "chronic", "hepatitis", "C", "C1623038#ent", "<e2>", "."], "h": {"id": "C0039841", "name": "C0039841#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [20, 21]}}
{"token": ["We", "recently", "reported", "that", "C1539233#ent", "<e1>", "was", "ubiquitinated", "by", "C3811801#ent", "<e2>", ",", "an", "ubiquitin", "E3", "ligase", "leading", "to", "proteasomal", "degradation"], "h": {"id": "C1539233", "name": "C1539233#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3811801", "name": "C3811801#ent", "pos": [9, 10]}}
{"token": ["Eight", "(", "two", "C3537143#ent", "<e1>", "susceptible", ",", "six", "C0282563#ent", "<e2>", "clinical", "isolates", "of", "S.", "pneumoniae", "investigated", "."], "h": {"id": "C3537143", "name": "C3537143#ent", "pos": [3, 4]}, "relation": "has_chemical_structure", "t": {"id": "C0282563", "name": "C0282563#ent", "pos": [8, 9]}}
{"token": ["Valacyclovir", "or", "C0209227#ent", "<e1>", "are", "the", "preferred", "first", "treatments", "for", "C0343570#ent", "<e2>", "of", "their", "clinical", "efficacy", "convenient", "dosing", "schedules", "."], "h": {"id": "C0209227", "name": "C0209227#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0343570", "name": "C0343570#ent", "pos": [10, 11]}}
{"token": ["The", "tRNA", "m(1)A58", "methyltransferase", "is", "composed", "of", "two", "C0599220#ent", "<e1>", "encoded", "by", "the", "essential", "genes", "and", "TRM61", "(", "formerly", "C1824795#ent", "<e2>", "and", "GCD14", ")", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1824795", "name": "C1824795#ent", "pos": [19, 20]}}
{"token": ["A", "variety", "of", "pain", "resembling", "the", "lightning", "pains", "tabes", "dorsalis", "described", "in", "patients", "suffering", "from", "persistent", "C0036396#ent", "<e1>", ",", "following", "laminectomy", "for", "C0263874#ent", "<e2>"], "h": {"id": "C0036396", "name": "C0036396#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0263874", "name": "C0263874#ent", "pos": [22, 23]}}
{"token": ["SCCA1", "neutralizes", "the", "papain-like", "cysteine", "proteinases", "cathepsins", "(", "cat", ")", "S", ",", "L", ",", "and", "K", ";", "and", "SCCA2", "inhibits", "the", "C0055673#ent", "<e1>", "catG", "and", "human", "C1413516#ent", "<e2>"], "h": {"id": "C0055673", "name": "C0055673#ent", "pos": [21, 22]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413516", "name": "C1413516#ent", "pos": [26, 27]}}
{"token": ["Human", "skin", "C0055673#ent", "<e1>", "human", "neutrophil", "cathepsin", "G", "rat", "C1413516#ent", "<e2>", "and", "rat", "salivary", "gland", "tonin", "are", "cell-derived", "serine", "proteinases", "similar", "size", "with", "specificity", "for", "amino", "acids", "aromatic", "residues", "."], "h": {"id": "C0055673", "name": "C0055673#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413516", "name": "C1413516#ent", "pos": [9, 10]}}
{"token": ["Separate", "application", "of", "3-isobutyl-1-methylxanthine", "(", "IBMX", ")", ",", "caffeine", ",", "theophylline", ",", "papaverine", "and", "C1413096#ent", "<e1>", "20", "-", "1724", "slowed", "down", "the", "time", "course", "C1424852#ent", "<e2>", "photo-response", "to", "dim", "flashes", "light", "."], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1424852", "name": "C1424852#ent", "pos": [24, 25]}}
{"token": ["C3160858#ent", "<e1>", "a", "treatable", "and", "reversible", "cause", "of", "C1306587#ent", "<e2>", "blindness", ",", "as", "long", "as", "an", "early", "diagnosis", "made", "."], "h": {"id": "C3160858", "name": "C3160858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1306587", "name": "C1306587#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "we", "found", "that", "C0164786#ent", "<e1>", "interacts", "with", "C1332116#ent", "<e2>", "and", "regulates", "HIF", "activity", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332116", "name": "C1332116#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "MAP", "may", "not", "be", "a", "determinant", "factor", "in", "the", "progression", "rate", "of", "advanced", "C1366488#ent", "<e1>", ",", "except", "possibly", "for", "patients", "with", "C0238304#ent", "<e2>", "very", "low", "MAP", "."], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0238304", "name": "C0238304#ent", "pos": [25, 26]}}
{"token": ["It", "is", "concluded", "that", "C0052527#ent", "<e1>", "identical", "with", "C0002570#ent", "<e2>", "EC", "3.4.11.6", ")", "from", "other", "mammalian", "tissues", "."], "h": {"id": "C0052527", "name": "C0052527#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002570", "name": "C0002570#ent", "pos": [8, 9]}}
{"token": ["C0073374#ent", "<e1>", "pharmacokinetics", "were", "evaluated", "in", "individuals", "challenged", "with", "C0302359#ent", "<e2>"], "h": {"id": "C0073374", "name": "C0073374#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0302359", "name": "C0302359#ent", "pos": [9, 10]}}
{"token": ["A", "comparative", "analysis", "the", "enamel", "microsomal", "kinase", "against", "osteopontin", ",", "dephosphorylated", "casein", "C1415840#ent", "<e1>", "no", "phosphorylation", "of", "the", "first", "two", "C0086376#ent", "<e2>", ",", "and", "only", "minor", "phosphorylation", "of", "the", "C1415840#ent", "<e1>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1415840", "name": "C1415840#ent", "pos": [12, 13]}}
{"token": ["When", "yeast", "coexpressing", "C1307053#ent", "<e1>", ",", "Csk", ",", "and", "C2987154#ent", "<e2>", "incubated", "with", "pervanadate", ",", "C2987154#ent", "<e2>", "tyrosine", "phosphorylated", "and", "[3H]IP2", "and", "[3H]IP3", "production", "increased", "11.0-", "and", "7.0-fold", ",", "respectively", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [9, 10]}}
{"token": ["C1307053#ent", "<e1>", "expressed", "alone", "with", "C2987154#ent", "<e2>", "ineffective", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [5, 6]}}
{"token": ["Statins", "have", "been", "shown", "to", "diminish", "significantly", "the", "risk", "for", "C1956346#ent", "<e1>", "patients", "with", "type", "2", "diabetes", "and", "so", "what", "are", "the", "real", "effects", "C3540783#ent", "<e2>", "on", "cardiovascular", "risk", "type", "2", "diabetes"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540783", "name": "C3540783#ent", "pos": [24, 25]}}
{"token": ["Among", "the", "differentially", "expressed", "C0017337#ent", "<e1>", "with", "informative", "annotation", "were", "C1456349#ent", "<e2>", ",", "glutathione", "S-transferase", "and", "a", "putative", "salivary", "protein", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1456349", "name": "C1456349#ent", "pos": [10, 11]}}
{"token": ["Both", "CSF-induced", "macrophages", "expressed", "similar", "sets", "of", "C0017337#ent", "<e1>", "except", "for", "several", "C0017337#ent", "<e1>", "such", "as", "monocyte-derived", "chemokine", "MDC", ")", ",", "C1456349#ent", "<e1>", ",", "prostaglandin", "D", "synthetase", "and", "lysosomal", "sialoglycoprotein"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1456349", "name": "C1456349#ent", "pos": [21, 22]}}
{"token": ["Aortitis", "and", "C0003504#ent", "<e1>", "fairly", "uncommon", "in", "C0156147#ent", "<e2>"], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [7, 8]}}
{"token": ["The", "use", "of", "3-hydroxy-3-methylglutaryl", "coenzyme", "A", "HMG-CoA", ")", "reductase", "inhibitors", "(", "e.g.", "C0085542#ent", "<e1>", ")", "has", "gradually", "increased", "in", "the", "treatment", "of", "C0020443#ent", "<e2>", "."], "h": {"id": "C0085542", "name": "C0085542#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [22, 23]}}
{"token": ["C0085542#ent", "<e1>", "is", "an", "HMG", "CoA", "reductase", "inhibitor", "in", "the", "treatment", "of", "C0020443#ent", "<e2>", "."], "h": {"id": "C0085542", "name": "C0085542#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [12, 13]}}
{"token": ["We", "previously", "reported", "that", "C3890739#ent", "<e1>", "directly", "activates", "proinflammatory", "and", "atherogenic", "signaling", "in", "vascular", "endothelial", "cells", "C1514550#ent", "<e2>", "PKCbeta", ")", "."], "h": {"id": "C3890739", "name": "C3890739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [16, 17]}}
{"token": ["On", "average", ",", "a", "C0982341#ent", "<e1>", "preparation", "provided", "significantly", "less", "residual", "fluid", "than", "a", "C0032483#ent", "<e2>", "preparation", "."], "h": {"id": "C0982341", "name": "C0982341#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [14, 15]}}
{"token": ["The", "activation", "of", "C2986464#ent", "<e1>", "is", "increased", "in", "tracheal", "aspirate", "TA", ")", "cells", "from", "premature", "infants", "C0006287#ent", "<e2>", "BPD", ")", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006287", "name": "C0006287#ent", "pos": [16, 17]}}
{"token": ["An", "association", "with", "preeclampsia", ",", "C3828492#ent", "<e1>", "and", "infant", "C0020615#ent", "<e2>", "was", "verified", "."], "h": {"id": "C3828492", "name": "C3828492#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [9, 10]}}
{"token": ["With", "presumably", "tighter", "control", "of", "C3828492#ent", "<e1>", "the", "risk", "of", "symptomatic", "C0020615#ent", "<e2>", "appears", "diminished", "."], "h": {"id": "C3828492", "name": "C3828492#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [11, 12]}}
{"token": ["Quantitative", "RT-PCR", "using", "the", "intestinal", "cell", "line", "Caco2", "revealed", "that", "Cdx2", "and", "C0028941#ent", "<e1>", "were", "down-regulated", "and", "gastric", "mucins", "C2983560#ent", "<e2>", "and", "MUC6", "were", "up-regulated", "under", "acidic", "culture", "conditions"], "h": {"id": "C0028941", "name": "C0028941#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2983560", "name": "C2983560#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "biannual", "C0022322#ent", "<e1>", "treatment", "at", "the", "community", "level", "on", "transmission", "of", "C0029001#ent", "<e2>", "the", "dry", "season", "measured", "over", "a", "30-month", "period", "in", "Guatemala", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0029001", "name": "C0029001#ent", "pos": [14, 15]}}
{"token": ["The", "clinical", "features", "of", "C0149519#ent", "<e1>", "are", "variable", "and", "may", "resemble", "those", "of", "C1565106#ent", "<e2>", "migraine", ",", "tension-type", "headache", "cluster", "headache", ",", "as", "well", "as", "of", "cervicogenic", "headache"], "h": {"id": "C0149519", "name": "C0149519#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565106", "name": "C1565106#ent", "pos": [13, 14]}}
{"token": ["Both", "had", "a", "longer", "duration", "of", "C3494359#ent", "<e1>", "symptoms", ",", "lower", "levels", "of", "circulating", "C1332309#ent", "<e2>", "histological", "evidence", "of", "less", "aggressive", "disease"], "h": {"id": "C3494359", "name": "C3494359#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332309", "name": "C1332309#ent", "pos": [14, 15]}}
{"token": ["In", "some", "C0042384#ent", "<e1>", "as", "nodose", "panarteritis", "PN", ")", ",", "hemolytic-uremic", "syndrome", "HUS", ")", ",", "C0034155#ent", "<e2>", "TTP", ")", ",", "parenchymal", "perfusion", "is", "reduced", "and", "RI", "increased", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034155", "name": "C0034155#ent", "pos": [15, 16]}}
{"token": ["Clinically", ",", "CAPS", "mimics", "disseminated", "C0042384#ent", "<e1>", "intravascular", "coagulation", "DIC", ")", ",", "and", "particularly", "C0034155#ent", "<e2>", "TTP", ")", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034155", "name": "C0034155#ent", "pos": [14, 15]}}
{"token": ["Clinically", ",", "CAPS", "mimics", "disseminated", "C0042384#ent", "<e1>", "intravascular", "coagulation", "DIC", ")", ",", "and", "particularly", "thrombotic", "thrombocytopenic", "purpura", "C0034155#ent", "<e2>", ")", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034155", "name": "C0034155#ent", "pos": [17, 18]}}
{"token": ["We", "present", "the", "case", "of", "a", "C0024796#ent", "<e1>", "patient", "who", "successfully", "underwent", "repair", "of", "a", "C0017547#ent", "<e2>", "ascending", "aortic", "pseudoaneurysm", "concomitant", "repair", "of", "an", "abdominal", "aortic", "aneurysm"], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [15, 16]}}
{"token": ["The", "ability", "of", "C0024796#ent", "<e1>", "to", "form", "new", "C0017547#ent", "<e2>", "synapses", "within", "isolated", "tissue", "slices", "was", "established", "by", "a", "series", "of", "experiments", "involving", "synapsin", "I", "immunohistochemistry", "electron", "microscopy", "and", "whole-cell", "recordings"], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [8, 9]}}
{"token": ["The", "authors", "describe", "the", "case", "of", "a", "C0024796#ent", "<e1>", "presented", "a", "C0017547#ent", "<e2>", "intracranial", "internal", "carotid", "aneurysm", "associated", "with", "elongation", "and", "tortuosity", "of", "internal", "carotid", "vertebral", "arteries", "both", "sides", "."], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [11, 12]}}
{"token": ["CDP-choline", ":", "C0008420#ent", "<e1>", "activity", "was", "increased", "by", "both", "in", "vivo", "C0011849#ent", "<e2>"], "h": {"id": "C0008420", "name": "C0008420#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}}
{"token": ["Repair", "was", "studied", "in", "the", "transcriptionally", "active", "gene", "dihydrofolate", "reductase", "C1333216#ent", "<e1>", ")", ",", "the", "inactive", "delta", "globin", "gene", "and", "in", "the", "c-myc", "C0033713#ent", "<e2>", "."], "h": {"id": "C1333216", "name": "C1333216#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033713", "name": "C0033713#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "the", "first", "case", ",", "to", "the", "best", "of", "our", "knowledge", ",", "of", "an", "anaphylactoid", "reaction", "C0291140#ent", "<e1>", "in", "a", "patient", "who", "tolerated", "C0017768#ent", "<e2>", "."], "h": {"id": "C0291140", "name": "C0291140#ent", "pos": [17, 18]}, "relation": "has_structural_class", "t": {"id": "C0017768", "name": "C0017768#ent", "pos": [24, 25]}}
{"token": ["In", "conclusion", "this", "study", "indicates", "that", "chronic", "C4283784#ent", "<e1>", "treatment", "inhibits", "DCA-induced", "PKC", "and", "C1417708#ent", "<e2>", "colon", "cancer", "cells"], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [14, 15]}}
{"token": ["Electrophoretic", "mobility", "shift", "assay", "experiments", "demonstrated", "that", "C4283784#ent", "<e1>", "(", "100", "microM", ")", "dramatically", "reduced", "activation", "of", "nuclear", "factor-kappaB", "C1417708#ent", "<e2>", ")", ",", "activator", "protein-1", "AP-1", ")", "and", "cAMP", "response", "element", "binding", "protein", "CREB", ")", "induced", "by", "LPS/IFN-gamma", "."], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [19, 20]}}
{"token": ["C1366496#ent", "<e1>", "is", "the", "enzyme", "which", "catalyses", "the", "conversion", "of", "C0038317#ent", "<e2>", "C18", "estrogens", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [10, 11]}}
{"token": ["The", "induction", "of", "C1366496#ent", "<e1>", "activity", "by", "C0038317#ent", "<e2>", "appears", "to", "be", "greater", "in", "males", "than", "in", "females", ",", "but", "this", "difference", "has", "been", "difficult", "to", "localize", "and", "confirm", "by", "assay", "methods"], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [7, 8]}}
{"token": ["A", "heterogeneous", "group", "C0541746#ent", "<e1>", "(", "indapamide", ",", "metolazone", ",", "hydroflumethiazide", ",", "chlorthalidone", "and", "C0004975#ent", "<e2>", ")", "has", "been", "studied", "."], "h": {"id": "C0541746", "name": "C0541746#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C0004975", "name": "C0004975#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "effect", "of", "two", "neuroleptics", ",", "C0016367#ent", "<e1>", "and", "trifluperidol", ",", "on", "the", "release", "of", "pro-apoptotic", "C0812246#ent", "<e2>", "and", "NO", "by", "LPS-activated", "rat", "microglial", "cells"], "h": {"id": "C0016367", "name": "C0016367#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [24, 25]}}
{"token": ["We", "examined", "whether", "or", "not", "inhibition", "of", "Ca2", "+", "signaling", "was", "mediating", "SS-induced", "inhibition", "basal", ",", "as", "well", "as", "C1415169#ent", "<e1>", "GnRH", ";", "a", "C1259877#ent", "<e2>", "growth", "hormone", "growth", "hormone", "GH", ")", "release", "."], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [24, 25]}}
{"token": ["Like", "C1415169#ent", "<e1>", ",", "a", "calcium", "ionophore", "A23187", ")", "and", "activators", "of", "C1259877#ent", "<e2>", "attenuate", "the", "steroidogenic", "response", "of", "the", "cells", "to", "follicle-stimulating", "hormone", "but", "enhance", "the", "formation", "of", "gonadotropin-induced", "prostaglandin", "formation", "."], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [12, 13]}}
{"token": ["Endogenous", "levels", "of", "C1705281#ent", "<e1>", "mRNA", "and", "protein", "in", "C1825769#ent", "<e2>", "clones", "permanently", "overexpressing", "c-ErbB2", "or", "V12-H-Ras", "were", "markedly", "reduced", "compared", "with", "levels", "in", "the", "parental", "cell", "lines"], "h": {"id": "C1705281", "name": "C1705281#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1825769", "name": "C1825769#ent", "pos": [9, 10]}}
{"token": ["Clear", "cell", "sarcoma", "CCS", ")", "is", "associated", "with", "C3274614#ent", "<e1>", "oncogene", "that", "is", "created", "by", "chromosomal", "fusion", "the", "Ewings", "Sarcoma", "oncogene", "C0808901#ent", "<e2>", ")", "and", "the", "cellular", "transcription", "factor", "ATF1", "."], "h": {"id": "C3274614", "name": "C3274614#ent", "pos": [8, 9]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [21, 22]}}
{"token": ["In", "order", "to", "elucidate", "the", "enzymatic", "function", "C1447694#ent", "<e1>", "we", "investigated", "the", "substrate", "of", "C1447694#ent", "<e1>", "and", "expression", "of", "C1416671#ent", "<e1>", ",", "the", "gene", "encoding", "C1447694#ent", "<e1>", "."], "h": {"id": "C1447694", "name": "C1447694#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [19, 20]}}
{"token": ["In", "SDS-PAGE", ",", "the", "C1447694#ent", "<e1>", "a", "single", "band", "34", "kD.", "The", "purified", "C1416671#ent", "<e2>", "potent", "allergenic", "activity", "."], "h": {"id": "C1447694", "name": "C1447694#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [13, 14]}}
{"token": ["Homology", "search", "using", "the", "amino", "acid", "sequence", "that", "C1447694#ent", "<e1>", "identical", "to", "TLSP", "(", "C1416671#ent", "<e2>", ")", ",", "which", "is", "expressed", "in", "human", "primary", "keratinocytes", "1", ")", "."], "h": {"id": "C1447694", "name": "C1447694#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [14, 15]}}
{"token": ["The", "results", "of", "these", "studies", "show", "that", "C0032950#ent", "<e1>", "pretreatment", "lowers", "the", "C0027203#ent", "<e2>", "efflux", "from", "isolated", "skeletal", "muscle", "but", "not", "from", "heart", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["However", ",", "in", "kidney", ",", "pyridoxine", "deficiency", "suppressed", "both", "C0027203#ent", "<e1>", "activities", ",", "while", "treatment", "with", "C0032950#ent", "<e2>", "did", "not", "induce", "either", "C0027203#ent", "<e1>", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["To", "compare", "the", "cyclooxygenase", "(", "COX", ")", "activity", "and", "anti-inflammatory", "effects", "the", "nonsteroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", "ketorolac", "tromethamine", "ketorolac", ")", "and", "bromfenac", "sodium", "C0054094#ent", "<e2>", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [15, 16]}, "relation": "structural_class_of", "t": {"id": "C0054094", "name": "C0054094#ent", "pos": [25, 26]}}
{"token": ["To", "compare", "the", "cyclooxygenase", "(", "COX", ")", "activity", "and", "anti-inflammatory", "effects", "the", "C0003211#ent", "<e1>", "NSAIDs", ")", "ketorolac", "tromethamine", "ketorolac", ")", "and", "C0054094#ent", "<e2>", "bromfenac", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}, "relation": "structural_class_of", "t": {"id": "C0054094", "name": "C0054094#ent", "pos": [21, 22]}}
{"token": ["To", "compare", "the", "cyclooxygenase", "(", "COX", ")", "activity", "and", "anti-inflammatory", "effects", "the", "nonsteroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", "ketorolac", "tromethamine", "ketorolac", ")", "and", "C0054094#ent", "<e2>", "bromfenac", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [15, 16]}, "relation": "structural_class_of", "t": {"id": "C0054094", "name": "C0054094#ent", "pos": [23, 24]}}
{"token": ["C0006684#ent", "<e1>", "safe", "and", "effective", "in", "the", "treatment", "of", "C0020538#ent", "<e2>"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}}
{"token": ["Based", "on", "the", "vasodilator", "properties", "of", "C0006684#ent", "<e1>", "verapamil", "was", "recently", "introduced", "into", "the", "treatment", "of", "C0020538#ent", "<e2>"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["There", "is", "a", "considerable", "controversy", "about", "the", "postulated", "role", "of", "the", "Thr(671)-Leu(690", ")", "(", "C0030956#ent", "<e1>", "of", "the", "C0220821#ent", "<e2>", "(", "DHP", ")", "receptor", "alpha1", "II-III", "loop", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0220821", "name": "C0220821#ent", "pos": [18, 19]}}
{"token": ["A", "review", "of", "the", "literature", "shows", "that", "hematologic", "malignancies", "an", "uncommon", "cause", "of", "C0162557#ent", "<e1>", "and", "that", "C0796355#ent", "<e2>", "a", "relatively", "recently", "recognized", "entity", "which", "is", "characteristically", "CD3", "+", "and", "CD56+"], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0796355", "name": "C0796355#ent", "pos": [17, 18]}}
{"token": ["To", "investigate", "the", "expressions", "of", "and", "the", "effect", "of", "smoking", "on", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "and", "induced", "C0907533#ent", "<e1>", "iNOS", ")", "in", "lung", "tissues", "chronic", "obstructive", "pulmonary", "disease", "C1647218#ent", "<e2>", ")", "patients", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [30, 31]}}
{"token": ["Azathioprine", ",", "a", "C0003376#ent", "<e1>", "in", "the", "treatment", "of", "C0272286#ent", "<e2>", "human", "beings", "and", "dogs", ",", "was", "used", "in", "2", "cases", "of", "C0272286#ent", "<e2>", "horses", "that", "failed", "to", "respond", "to", "corticosteroid", "therapy", "."], "h": {"id": "C0003376", "name": "C0003376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0272286", "name": "C0272286#ent", "pos": [9, 10]}}
{"token": ["The", "clinical", "outcome", "patients", "with", "membranoproliferative", "glomerulonephritis", "C0268743#ent", "<e1>", ")", "varies", ",", "with", "some", "patients", "progressing", "to", "C0022661#ent", "<e2>"], "h": {"id": "C0268743", "name": "C0268743#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [17, 18]}}
{"token": ["This", "multicenter", ",", "stratified", ",", "randomized", ",", "placebo-controlled", ",", "double-blind", "trial", "C0146011#ent", "<e1>", "for", "use", "in", "the", "United", "States", "spasticity", "secondary", "to", "C0026769#ent", "<e2>", "."], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [22, 23]}}
{"token": ["In", "a", "double-blind", "comparative", "study", "the", "therapeutic", "efficacy", "safety", "of", "three", "centrally", "effective", "antispasmodics", "(", "Tetrazepam", ",", "Baclofen", "and", "C0146011#ent", "<e1>", ")", "in", "patients", "suffering", "from", "C0026769#ent", "<e2>", "spastic", "motor", "disturbances", "the", "lower", "extremities", "to", "be", "examined", "."], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [26, 27]}}
{"token": ["This", "symposium", "is", "concerned", "with", "the", "treatment", "of", "spasticity", "and", ",", "in", "particular", ",", "with", "results", "from", "studies", "of", "C0146011#ent", "<e1>", "as", "a", "treatment", "for", "patients", "with", "C0026769#ent", "<e2>", "and", "spinal", "cord", "injury"], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [27, 28]}}
{"token": ["Average", "sensitivity", "for", "C1367472#ent", "<e1>", "cases", "only", "was", "62.6", "%", "for", "C1956346#ent", "<e2>", "and", "64.8", "%", "for", "DOUBLE", "(", "chi(2)=0.32", ",", "df=1", ",", "P=0.58", ")", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}}
{"token": ["Partial", "purification", "of", "the", "hamster", "colon", "cytosol", "by", "anion", "exchange", "chromatography", "two", "C0796518#ent", "<e1>", "to", "those", "previously", "described", "in", "C0023899#ent", "<e2>", "and", "urinary", "bladder"], "h": {"id": "C0796518", "name": "C0796518#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}}
{"token": ["C0796518#ent", "<e1>", "detected", "in", "feline", "C0023899#ent", "<e2>", ",", "bladder", "and", "colon", "using", "an", "NAT1-specific", "antipeptide", "antibody", "but", "was", "not", "detected", "in", "any", "tissues", "using", "an", "NAT2-specific", "antibody", "."], "h": {"id": "C0796518", "name": "C0796518#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [5, 6]}}
{"token": ["C0796518#ent", "<e1>", "NAT2", ")", ",", "which", "exists", "in", "the", "human", "C0023899#ent", "<e2>", "and", "metabolizes", "a", "wide", "spectrum", "of", "arylamine", ",", "is", "encoded", "by", "one", "gene", "(", "NAT2", ")", "."], "h": {"id": "C0796518", "name": "C0796518#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["Treatment", "of", "rat", "hepatocytes", "with", "100", "mM", "ethanol", "in", "vitro", "16", "h", "prolonged", "the", "activation", "of", "p42/44", "MAPK", "and", "C0257535#ent", "<e1>", "induced", "by", "various", "C2987634#ent", "<e2>", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [24, 25]}}
{"token": ["The", "peak", "of", "CRF", "transcription", "was", "parallel", "to", "that", "of", "cAMP", "response-element", "binding", "protein", "C1705055#ent", "<e1>", ")", "phosphorylation", "but", "preceded", "the", "induction", "of", "C1706383#ent", "<e2>", "and", "NGFI-B", "mRNAs", "and", "Fos", "protein"], "h": {"id": "C1705055", "name": "C1705055#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [23, 24]}}
{"token": ["We", "propose", "that", "posttranslational", "modification", "of", "C1705055#ent", "<e1>", "regulates", "serum", "inducibility", "of", "C1706383#ent", "<e2>", "promoter", "."], "h": {"id": "C1705055", "name": "C1705055#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [12, 13]}}
{"token": ["Mapmodulin", "inhibits", "the", "initial", "rate", "of", "C1424480#ent", "<e1>", "binding", "to", "microtubules", ",", "a", "property", "that", "may", "allow", "C1421894#ent", "<e2>", "to", "displace", "MAPs", "from", "the", "path", "of", "organelles", "translocating", "along", "microtubules", "."], "h": {"id": "C1424480", "name": "C1424480#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421894", "name": "C1421894#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "C0442874#ent", "<e1>", "a", "46", "year", "old", "female", "with", "C0162532#ent", "<e2>"], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0162532", "name": "C0162532#ent", "pos": [13, 14]}}
{"token": ["We", "asked", "whether", "this", "C1417123#ent", "<e1>", "belongs", "to", "latent", "C1517488#ent", "<e2>"], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [9, 10]}}
{"token": ["p63", "is", "an", "C1417123#ent", "<e1>", "belonging", "to", "the", "C1517488#ent", "<e2>"], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [8, 9]}}
{"token": ["In", "each", "case", "the", "C1417123#ent", "<e1>", "involved", "was", "N-ras", ",", "a", "member", "of", "the", "C1517488#ent", "<e2>"], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [14, 15]}}
{"token": ["Aluminum", "ions", "greatly", "catalyze", "the", "conversion", "reaction", "C0114832#ent", "<e1>", "to", "form", "C0048921#ent", "<e2>", ",", "which", "is", "a", "key", "step", "in", "the", "biosynthesis", "of", "melanin", "."], "h": {"id": "C0114832", "name": "C0114832#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0048921", "name": "C0048921#ent", "pos": [11, 12]}}
{"token": ["Both", "cupric", "ions", "DCT", "catalyse", "the", "rearrangement", "of", "C0114832#ent", "<e1>", "to", "give", "5,6-dihydroxyindole-2-carboxylic", "acid", "DICA", ")", "rather", "than", "C0048921#ent", "<e2>", "(", "DI", ")", "."], "h": {"id": "C0114832", "name": "C0114832#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0048921", "name": "C0048921#ent", "pos": [18, 19]}}
{"token": ["D2", "congenic", "mice", "which", "have", "the", "wild-type", "C1419254#ent", "<e1>", "makes", "them", "resistant", "to", "C0036117#ent", "<e2>", "."], "h": {"id": "C1419254", "name": "C1419254#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [13, 14]}}
{"token": ["We", "propose", "that", "C1419254#ent", "<e1>", "counteracts", "the", "ability", "of", "C0036117#ent", "<e2>", "to", "become", "secluded", "in", "a", "compartment", "that", "limits", "access", "of", "bactericidal", "agents", "allowing", "the", "normal", "degradative", "pathway", "the", "macrophage", "to", "proceed", "."], "h": {"id": "C1419254", "name": "C1419254#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [9, 10]}}
{"token": ["In", "the", "latter", "population", ",", "no", "association", "between", "the", "C1419254#ent", "<e1>", "genotypes", "and", "the", "colon", "C0036117#ent", "<e2>", "the", "ELISA", "status", "could", "be", "demonstrated", "."], "h": {"id": "C1419254", "name": "C1419254#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [15, 16]}}
{"token": ["Ten", "B", "cell", "epitopes", "predicted", "using", "computational", "software", "one", "showed", "90", "%", "homology", "to", "an", "important", "C1415975#ent", "<e1>", "epitope", "of", "C4283784#ent", "<e2>", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "various", "cytokines", "(", "IL-1", "alpha", "C1334119#ent", "<e1>", ",", "IL-6", ",", "transforming", "growth", "factor-beta", "fail", "to", "reinduce", "C2697529#ent", "<e2>", "on", "CD31-", "clones", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2697529", "name": "C2697529#ent", "pos": [18, 19]}}
{"token": ["The", "C0038160#ent", "<e1>", "26.6", "%", "of", "all", "C0004623#ent", "<e2>", "the", "Intensive", "Care", "Unit", "the", "Department", "of", "Anesthesiology", "Intensive", "Care", "the", "Medical", "Academy", "in", "Bia\u0142ystok", ",", "during", "one", "year", "observation", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}}
{"token": ["The", "pro-adhesive", "effect", "of", "CRP", "was", "abolished", "by", "calphostin", "C", "a", "C1415545#ent", "<e1>", ",", "whereas", "the", "extracellular", "signal-regulated", "kinase", "antagonist", "C0298346#ent", "<e2>", ",", "did", "not", "have", "any", "effect", "."], "h": {"id": "C1415545", "name": "C1415545#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0298346", "name": "C0298346#ent", "pos": [20, 21]}}
{"token": ["Isoguvacine", "(", "50", "microM", ")", "a", "specific", "GABAA", "C2987634#ent", "<e1>", ",", "potentiated", "the", "C3539699#ent", "<e2>", "+", "-evoked", "release", "of", "alpha", "MSH"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [13, 14]}}
{"token": ["Increased", "activity", "against", "colorectal", "cancer", "5-fluorouracil", "(", "5-Fu", ")", "modulation", "with", "C2721771#ent", "<e1>", "(", "LV", ")", "and/or", "interferon", "(", "C1415900#ent", "<e2>", ")", "has", "been", "reported", "."], "h": {"id": "C2721771", "name": "C2721771#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [19, 20]}}
{"token": ["Twenty-four", "patients", "with", "advanced", "or", "relapsed", "gastric", "or", "colorectal", "cancer", "treated", "with", "combination", "of", "5-fluorouracil", "(", "5-FU", ")", ",", "C2721771#ent", "<e1>", "(", "LV", ")", "and", "interferon-alpha", "(", "C1415900#ent", "<e2>", ")", "."], "h": {"id": "C2721771", "name": "C2721771#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [27, 28]}}
{"token": ["The", "C0014442#ent", "<e1>", "lacks", "detectable", "C0059944#ent", "<e2>", "or", "endonuclease", "activity"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059944", "name": "C0059944#ent", "pos": [5, 6]}}
{"token": ["The", "C0014442#ent", "<e1>", "behaves", "as", "an", "C0059944#ent", "<e2>", "by", "producing", "3'-deoxymononucleotides", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059944", "name": "C0059944#ent", "pos": [6, 7]}}
{"token": ["To", "explore", "if", "there", "is", "any", "change", "of", "the", "level", "of", "plama", "C1705783#ent", "<e1>", "and", "ADM", "in", "C0029456#ent", "<e2>"], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0029456", "name": "C0029456#ent", "pos": [17, 18]}}
{"token": ["In", "most", "cases", ",", "either", "an", "approximately", "800-bp", "fragment", "from", "C1420225#ent", "<e1>", "or", "an", "approximately", "200-bp", "fragment", "from", "C2985256#ent", "<e2>", "is", "amplified", "."], "h": {"id": "C1420225", "name": "C1420225#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [18, 19]}}
{"token": ["The", "most", "common", "enzyme", "was", "a", "Citrobacter", "freundii-derived", "cephalosporinase", "(", "C1420225#ent", "<e1>", ")", "which", "differed", "from", "C2985256#ent", "<e2>", "by", "three", "amino", "acids"], "h": {"id": "C1420225", "name": "C1420225#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "C1420225#ent", "<e1>", "mediates", "facilitated", "diffusion", "of", "substrate", "amino", "acids", "as", "distinct", "from", "C2985256#ent", "<e2>", ",", "which", "mediates", "amino", "acid", "exchange", "."], "h": {"id": "C1420225", "name": "C1420225#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [15, 16]}}
{"token": ["Continuous", "C3539616#ent", "<e1>", "treatment", "also", "feminized", "the", "expression", "of", "endogenous", "murine", "C1539208#ent", "<e2>", "and", "Cyp3a44", "genes"], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1539208", "name": "C1539208#ent", "pos": [11, 12]}}
{"token": ["Incubation", "of", "cultured", "endothelial", "cells", "100", "mu", "mol/L", "C0006979#ent", "<e1>", "for", "24", "hours", "did", "not", "inhibit", "C0132555#ent", "<e2>", "activity", ",", "as", "measured", "by", "conversion", "of", "[3H]L-arginine", "to", "[3H]L-citrulline", "."], "h": {"id": "C0006979", "name": "C0006979#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [16, 17]}}
{"token": ["Activation", "of", "the", "Erk", "pathway", "necessary", ",", "but", "not", "sufficient", "for", "full", "induction", "of", "C1333337#ent", "<e1>", "upreglation", "by", "C0282625#ent", "<e2>"], "h": {"id": "C1333337", "name": "C1333337#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [18, 19]}}
{"token": ["The", "results", "fail", "to", "confirm", "a", "previously", "reported", "increase", "in", "HLA-A1", "and", "C1417639#ent", "<e1>", "in", "coalworkers", "with", "C0003165#ent", "<e2>"], "h": {"id": "C1417639", "name": "C1417639#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003165", "name": "C0003165#ent", "pos": [17, 18]}}
{"token": ["Precipitation", "with", "C0032478#ent", "<e1>", "gave", "higher", "fluorescent", "values", "and", "C0795965#ent", "<e2>", "transformants", "than", "a", "similar", "method", "without", "C0032478#ent", "<e1>", "."], "h": {"id": "C0795965", "name": "C0795965#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032478", "name": "C0032478#ent", "pos": [2, 3]}}
{"token": ["The", "effects", "of", "C0069535#ent", "<e1>", "the", "expression", "of", "different", "cytochrome", "P450", "C0010762#ent", "<e2>", ")", "isozymes", "has", "been", "investigated", "in", "human", "hepatocytes", "."], "h": {"id": "C0069535", "name": "C0069535#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [11, 12]}}
{"token": ["This", "order", "of", "affinities", "is", "the", "reverse", "of", "that", "of", "GalR", ",", "which", "binds", "most", "strongly", "to", "the", "operator", "of", "C3812647#ent", "<e1>", "and", "most", "weakly", "to", "that", "of", "C4049597#ent", "<e2>", "."], "h": {"id": "C3812647", "name": "C3812647#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C4049597", "name": "C4049597#ent", "pos": [28, 29]}}
{"token": ["The", "increase", "in", "IgE", "to", "adult", "C0018889#ent", "<e1>", "was", "observed", "with", "different", "preparations", "of", "adult", "C0018889#ent", "<e1>", ",", "including", "the", "worm", "tegument", ",", "and", "with", "both", "C0032911#ent", "<e1>", "and", "oxamniquine", "therapy", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [26, 27]}}
{"token": ["Combined", "C0023817#ent", "<e1>", "CLD", ")", "is", "an", "autosomal", "recessive", "mutation", "C1706048#ent", "<e2>", ")", "in", "mice", "which", "impairs", "post-translational", "processing", "LPL", "and", "HL", "."], "h": {"id": "C0023817", "name": "C0023817#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706048", "name": "C1706048#ent", "pos": [10, 11]}}
{"token": ["Germ", "line", "C1566685#ent", "<e1>", "mutations", "cause", "50", "%", "of", "cases", "of", "C0041409#ent", "<e2>", "NS", ")", "."], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041409", "name": "C0041409#ent", "pos": [11, 12]}}
{"token": ["Heterozygous", "mutations", "PTPN11", ",", "which", "encodes", "C1566685#ent", "<e1>", ",", "cause", "approximately", "50", "%", "of", "cases", "of", "C0041409#ent", "<e2>"], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041409", "name": "C0041409#ent", "pos": [16, 17]}}
{"token": ["The", "C0020175#ent", "<e1>", "a", "characteristic", "hypoglycemic", "reaction", "100", "%", ";", "the", "C0040374#ent", "<e2>", "a", "positive", "result", "in", "92", "%", "."], "h": {"id": "C0020175", "name": "C0020175#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [11, 12]}}
{"token": ["Hydrogenated", "derivatives", "of", "C4055175#ent", "<e1>", "exhibited", "stronger", "DPPH", "scavenging", "activity", "compared", "to", "C4055175#ent", "<e1>", "and", "a", "reference", "antioxidant", ",", "C0147003#ent", "<e1>", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0147003", "name": "C0147003#ent", "pos": [19, 20]}}
{"token": ["Pyrazole", ",", "isoxazole", "analogues", "C4055175#ent", "<e1>", "(", "4", "and", "7", ")", "exhibited", "higher", "antioxidant", "activity", "C0147003#ent", "<e2>", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0147003", "name": "C0147003#ent", "pos": [15, 16]}}
{"token": ["C1539481#ent", "<e1>", "encodes", "a", "novel", "C1422076#ent", "<e2>", "SVHis", "a", "member", "of", "a", "gene", "family", "contains", "Armadillo-like", "repeats", ",", "and", "NAPE-PLD", "encodes", "a", "phospholipase", "D-type", "phosphodiesterase"], "h": {"id": "C1539481", "name": "C1539481#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422076", "name": "C1422076#ent", "pos": [5, 6]}}
{"token": ["Luminal", "trypsin", "activity", "may", "possibly", "be", "involved", "in", "C1334156#ent", "<e1>", "the", "intestine", "also", "in", "Atlantic", "salmon", "activation", "of", "C1334294#ent", "<e2>"], "h": {"id": "C1334156", "name": "C1334156#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334294", "name": "C1334294#ent", "pos": [18, 19]}}
{"token": ["The", "vast", "majority", "of", "C0020437#ent", "<e1>", "patients", "have", "disease", "secondary", "to", "cancer", ",", "C1840402#ent", "<e2>", ",", "or", "disorders", "of", "vitamin", "D", "metabolism", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [13, 14]}}
{"token": ["The", "urinary", "output", "beta", "2-microglobulin", "measured", "in", "ten", "C0020437#ent", "<e1>", "patients", "undergoing", "surgery", "because", "of", "C1840402#ent", "<e2>", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", ",", "we", "examined", "the", "thermodynamics", "of", "leucine", "binding", "C1416912#ent", "<e1>", "and", "to", "a", "leucine", "response", "mutant", ",", "C2987172#ent", "<e2>", ",", "and", "leucine-induced", "dissociation", "of", "Lrp", "hexadecamer", "to", "leucine-bound", "octamer", "."], "h": {"id": "C1416912", "name": "C1416912#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2987172", "name": "C2987172#ent", "pos": [20, 21]}}
{"token": ["Monoclonal", "antibody", "was", "reactive", "with", "eight", "clinical", "mouse-avirulent", "C1875400#ent", "<e1>", "but", "not", "with", "mouse-virulent", "laboratory", "strains", "RH", "and", "C1537501#ent", "<e2>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [18, 19]}}
{"token": ["This", "study", "reports", "comparative", "data", "on", "the", "DNA", "of", "14", "invertebrate", "iridovirus", "C1875400#ent", "<e1>", "used", "in", "the", "C1537501#ent", "<e2>", "and", "Cory", "study", "the", "two", "type", "vertebrate", "iridoviruses", "frog", "virus", "3", "flounder", "lymphocystis", "disease", "virus"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [17, 18]}}
{"token": ["C1415782#ent", "<e1>", ",", "an", "Escherichia", "coli", "homolog", "the", "C3539602#ent", "<e2>", "of", "molecular", "chaperonins", "has", "been", "implicated", "as", "a", "target", "of", "T", "cell-mediated", "immune", "responses", "a", "broad", "spectrum", "of", "infections", "."], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539602", "name": "C3539602#ent", "pos": [8, 9]}}
{"token": ["Production", "of", "amyloid-beta", "protein", "C1705543#ent", "<e1>", ")", "is", "initiated", "by", "a", "C1569775#ent", "<e2>", "that", "cleaves", "the", "Abeta", "precursor", "protein", "APP", ")", "at", "the", "N", "terminus", "of", "C1705543#ent", "<e1>", "(", "the", "beta", "site", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1569775", "name": "C1569775#ent", "pos": [11, 12]}}
{"token": ["C1705543#ent", "<e1>", "is", "proteolytically", "derived", "from", "its", "precursor", "protein", "cleavages", "by", "C1569775#ent", "<e2>", "and", "gamma-secretase", "complex", "presenilins", "(", "PS", ",", "PS1/PS2", ")", ",", "nicastrin", ",", "APH-1", "and", "PEN-2", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1569775", "name": "C1569775#ent", "pos": [11, 12]}}
{"token": ["However", ",", "in", "interphase", "Xenopus", "egg", "extracts", "with", "no", "detectable", "C1418727#ent", "<e1>", "and", "Cdk2", ",", "treatment", "with", "the", "phosphatase", "inhibitor", "C1720911#ent", "<e2>", "activated", "a", "distinct", "kinase", "that", "could", "phosphorylate", "and", "activate", "Cdc25", "."], "h": {"id": "C1418727", "name": "C1418727#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1720911", "name": "C1720911#ent", "pos": [20, 21]}}
{"token": ["Results", "of", "DNA", "sequence", "that", "apxIA", "gene", "can", "be", "divided", "into", "the", "original", "form", "including", "serotypes", "1", "9", "and", "11", ",", "and", "the", "C0002085#ent", "<e1>", "variant", "including", "serotypes", "5a", "C0537987#ent", "<e2>", "and", "10", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0537987", "name": "C0537987#ent", "pos": [29, 30]}}
{"token": ["Thirty-four", "pediatric", "patients", "with", "various", "bacterial", "infections", "tonsillitis", "2", "C0149514#ent", "<e1>", "pneumonia", "14", "pyothorax", "1", "sepsis", "1", "suppurative", "lymphadenitis", "1", "UTI", "13", "and", "C0014335#ent", "<e2>", "were", "treated", "with", "CZON", "at", "a", "daily", "dose", "40", "-", "94", "mg/kg", "t.i.d", "."], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [23, 24]}}
{"token": ["A", "total", "of", "21", "patients", "including", "3", "with", "pharyngitis", ",", "10", "with", "C0149514#ent", "<e1>", ",", "5", "with", "pneumonia", ",", "1", "each", "with", "C0014335#ent", "<e2>", "pyelonephritis", "and", "suspected", "sepsis", "were", "treated", "with", "."], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [22, 23]}}
{"token": ["In", "humans", ",", "histamine", "can", "be", "catabolized", "either", "by", "oxidative", "deamination", "C0019587#ent", "<e1>", "DAO", ")", "or", "by", "ring", "methylation", "C1415632#ent", "<e2>", "HNMT", ")", "."], "h": {"id": "C0019587", "name": "C0019587#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415632", "name": "C1415632#ent", "pos": [19, 20]}}
{"token": ["In", "humans", ",", "histamine", "can", "be", "catabolized", "either", "by", "oxidative", "deamination", "C0019587#ent", "<e1>", "DAO", ")", "or", "by", "ring", "methylation", "histamine", "N-methyltransferase", "C1415632#ent", "<e2>", ")", "."], "h": {"id": "C0019587", "name": "C0019587#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415632", "name": "C1415632#ent", "pos": [21, 22]}}
{"token": ["To", "compose", "both", "a", "multiple", "choice", "test", "(", "C0724624#ent", "<e1>", ")", "to", "evaluate", "primary", "care", "professionals", "understanding", "of", "C0019693#ent", "<e2>", "a", "scale", "to", "measure", "their", "attitudes", "towards", "it", "."], "h": {"id": "C0724624", "name": "C0724624#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [18, 19]}}
{"token": ["The", "proteolytic", "activity", "fXa", "in", "plasma", "is", "primarily", "regulated", "by", "three", "physiological", "inhibitors", "C0003438#ent", "<e1>", "(", "AT", ")", ",", "protein", "Z-dependent", "protease", "inhibitor", "(", "C1423896#ent", "<e2>", ")", "and", "tissue", "factor", "pathway", "inhibitor", "TFPI", ")", "."], "h": {"id": "C0003438", "name": "C0003438#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1423896", "name": "C1423896#ent", "pos": [24, 25]}}
{"token": ["Hermansky-Pudlak", "syndrome", "HPS", ")", "is", "a", "rare", "C3899988#ent", "<e1>", "by", "oculocutaneous", "albinism", "a", "C0032197#ent", "<e2>"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032197", "name": "C0032197#ent", "pos": [13, 14]}}
{"token": ["The", "Hermansky-Pudlak", "syndrome", "an", "C3899988#ent", "<e1>", "of", "the", "triad", "of", "oculocutaneous", "albinism", "a", "storage", "pool", "C0032197#ent", "<e2>", "and", "multisystem", "tissue", "deposition", "of", "ceroid", "pigment", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032197", "name": "C0032197#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "show", "that", "mediator", "of", "DNA", "damage", "checkpoint", "protein", "1", "C1332017#ent", "<e1>", ")", ",", "previously", "named", "C3539646#ent", "<e2>", "or", "Kiaa0170", ",", "is", "a", "proximate", "mediator", "of", "DNA", "damage", "responses", "that", "regulates", "BRCA1", "function", "."], "h": {"id": "C1332017", "name": "C1332017#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539646", "name": "C3539646#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "use", "siRNA", "to", "study", "a", "mediator", "of", "DNA", "damage-checkpoint", "protein", "1", "C1332017#ent", "<e1>", ")", ",", "previously", "known", "as", "Kiaa0170", "or", "C3539646#ent", "<e2>", ",", "in", "DNA", "damage", "responses", "."], "h": {"id": "C1332017", "name": "C1332017#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539646", "name": "C3539646#ent", "pos": [22, 23]}}
{"token": ["All", "six", "unvaccinated", "control", "dogs", "developed", "C0035204#ent", "<e1>", "by", "persistent", "C0019079#ent", "<e2>", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0019079", "name": "C0019079#ent", "pos": [10, 11]}}
{"token": ["Whereas", "no", "significant", "were", "observed", "in", "prostate", "carcinomas", "striking", "downregulation", "of", "the", "C1419742#ent", "<e1>", "and", "KIAA0828", "genes", "was", "observed", "in", "colon", "carcinomas", "C1417693#ent", "<e2>", "in", "a", "subset", "of", "lung", "carcinomas"], "h": {"id": "C1419742", "name": "C1419742#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417693", "name": "C1417693#ent", "pos": [22, 23]}}
{"token": ["Platelets", "from", "a", "thrombasthenic", "variant", ",", "which", "contained", "near-normal", "amounts", "of", "GPIIb-IIIa", ",", "failed", "to", "aggregate", "or", "bind", "C1537486#ent", "<e1>", "in", "response", "to", "C0243192#ent", "<e2>", "."], "h": {"id": "C1537486", "name": "C1537486#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [23, 24]}}
{"token": ["Analogs", "modified", "in", "the", "2'-position", "of", "the", "ribose", "induced", "stronger", "C1537486#ent", "<e1>", "activation", "than", "cAMP", "but", "were", "only", "partial", "C0243192#ent", "<e2>", "for", "cAPK", "."], "h": {"id": "C1537486", "name": "C1537486#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [19, 20]}}
{"token": ["The", "Ca(2+)-dependent", "lipid", "binding", "domain", "the", "C1744635#ent", "<e1>", "cPLA2", ")", "is", "a", "C1334043#ent", "<e2>", "of", "C2", "domains", "in", "protein", "kinase", "C", "synaptotagmin", ",", "and", "numerous", "other", "proteins", "involved", "in", "signal", "transduction"], "h": {"id": "C1744635", "name": "C1744635#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["The", "neutralizing", "ability", "of", "a", "monovalent", "anti-Micrurus", "nigrocinctus", "(", "coral", "snake", "antivenom", "produced", "in", "Costa", "Rica", "tested", "against", "the", "lethal", ",", "myotoxic", "and", "C1744635#ent", "<e1>", "activities", "of", "C1334043#ent", "<e2>"], "h": {"id": "C1744635", "name": "C1744635#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [27, 28]}}
{"token": ["The", "potency", "of", "clonidine", "in", "this", "C1416596#ent", "<e1>", "was", "approximately", "40", "times", "greater", "than", "that", "of", "C0043366#ent", "<e2>", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0043366", "name": "C0043366#ent", "pos": [16, 17]}}
{"token": ["The", "C0017337#ent", "<e1>", "for", "cyclin-dependent", "protein", "kinase", "inhibitor", "3", "C1332739#ent", "<e2>", ")", "was", "identified", "as", "a", "potential", "candidate", "C0017337#ent", "<e1>", "in", "a", "differential", "display", "experiment", "."], "h": {"id": "C1332739", "name": "C1332739#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}}
{"token": ["The", "C0017337#ent", "<e1>", "for", "C1332739#ent", "<e2>", "CDKN3", ")", "was", "identified", "as", "a", "potential", "candidate", "C0017337#ent", "<e1>", "in", "a", "differential", "display", "experiment", "."], "h": {"id": "C1332739", "name": "C1332739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}}
{"token": ["In", "1951", ",", "C0012383#ent", "<e1>", "was", "used", "to", "treat", "C0019202#ent", "<e2>", "striking", "success", "."], "h": {"id": "C0012383", "name": "C0012383#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [9, 10]}}
{"token": ["Of", "the", "104", "patients", "with", "C0024535#ent", "<e1>", "malaria", "treated", "with", "atovaquone", "plus", "C0008241#ent", "<e2>", "for", "3", "-", "7", "days", ",", "101", "were", "cured", "and", "had", "virtually", "no", "adverse", "side", "effects"], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0008241", "name": "C0008241#ent", "pos": [12, 13]}}
{"token": ["The", "increasing", "resistance", "of", "C0024535#ent", "<e1>", "malaria", "to", "common", "antimalarial", "drugs", "renewed", "interest", "in", "the", "C0008241#ent", "<e2>", "metabolized", "to", "cycloguanil", ",", "a", "strong", "dihydrofolate", "reductase", ",", "via", "the", "cytochrome", "P450", "isozyme", "CYP2C19", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0008241", "name": "C0008241#ent", "pos": [15, 16]}}
{"token": ["Among", "the", "activated", "C1883410#ent", "<e1>", ",", "cyclin", "D1", "pituitary", "tumor", "transforming", "gene-1", "cathespin", "D", "and", "C1336620#ent", "<e2>", "also", "found", "to", "over-express", "in", "human", "thyroid", "cancers"], "h": {"id": "C1883410", "name": "C1883410#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336620", "name": "C1336620#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "C0058310#ent", "<e1>", "not", "mediate", "C2987154#ent", "<e2>", "activation", "through", "binding", "to", "the", "TxA2", "receptor"], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [7, 8]}}
{"token": ["Endometrial", "tissue", "incubated", "in", "vitro", "assess", "release", "of", "C0058310#ent", "<e1>", "activity", "of", "phospholipase", "C", "C2987154#ent", "<e2>", ")", "in", "response", "to", "oxytocin", "."], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "C0011168#ent", "<e1>", "can", "be", "also", "the", "initial", "or", "late", "symptom", "several", "C0026636#ent", "<e2>", "e.g.", "traumatic", "ulcerations", "immunomediated", "or", "infectious", "lesions", "malignant", "neoplastic", "disease", "mucositis", "in", "chemio-radiotherapy", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0026636", "name": "C0026636#ent", "pos": [13, 14]}}
{"token": ["Dose", "response", "curves", "that", "C0600175#ent", "<e1>", "stimulated", "[3H]AA", "release", "by", "up", "to", "12-fold", "with", "an", "C0011516#ent", "<e2>", "of", "approximately", "0.4", "microM", ";", "maximal", "responses", "were", "obtained", "with", "10", "microM", "C0600175#ent", "<e1>", "."], "h": {"id": "C0600175", "name": "C0600175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011516", "name": "C0011516#ent", "pos": [15, 16]}}
{"token": ["In", "this", "review", "we", "present", "the", "latest", "information", "on", "the", "molecular", "basis", "C0001623#ent", "<e1>", "with", "special", "emphasis", "on", "congenital", "lipoid", "adrenal", "hyperplasia", "P450-oxidoreductase", "deficiency", "and", "C0342482#ent", "<e2>"], "h": {"id": "C0001623", "name": "C0001623#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0342482", "name": "C0342482#ent", "pos": [25, 26]}}
{"token": ["Our", "results", "suggest", "a", "basis", "for", "C0001623#ent", "<e1>", "hypogonadotropic", "hypogonadism", "males", "affected", "by", "C0342482#ent", "<e2>", "are", "consistent", "with", "a", "role", "for", "DAX1", "in", "gonadal", "sex", "determination", "."], "h": {"id": "C0001623", "name": "C0001623#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0342482", "name": "C0342482#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "report", "that", "three", "C1337090#ent", "<e1>", "patients", "carried", "two", "types", "of", "compound", "heterozygous", "mutations", "in", "C1335607#ent", "<e2>", "."], "h": {"id": "C1337090", "name": "C1337090#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335607", "name": "C1335607#ent", "pos": [17, 18]}}
{"token": ["MBP-A", "bound", "to", "lipid", "A", "Salmonella", "enterica", "serovar", "Minnesota", "rough", "C2697656#ent", "<e1>", "(", "S.", "enterica", "serovar", "Minnesota", "Re595", "and", "Escherichia", "coli", "J5", "C1419366#ent", "<e2>", ")", ",", "but", "not", "to", "smooth", "C2697656#ent", "<e1>", "(", "E.", "coli", "and", "O111:B4", ")", "."], "h": {"id": "C1419366", "name": "C1419366#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "long-term", "exposure", "to", "C0051510#ent", "<e1>", "on", "the", "development", "of", "C1843013#ent", "<e2>", "neuropathological", "changes", "have", "been", "studied", "post-mortem", "in", "patients", "with", "chronic", "renal", "failure", "did", "not", "have", "dialysis", "encephalopathy"], "h": {"id": "C0051510", "name": "C0051510#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1843013", "name": "C1843013#ent", "pos": [12, 13]}}
{"token": ["Most", "recently", ",", "a", "clinical", "trial", "revealed", "the", "beneficial", "effects", "of", "C1334089#ent", "<e1>", "in", "amyotrophic", "lateral-sclerosis", "ALS", ")", ",", "a", "C1285162#ent", "<e2>", "the", "motoneurones", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [20, 21]}}
{"token": ["Paradoxically", ",", "C4283933#ent", "<e1>", "are", "reported", "to", "stimulate", "cytosolic", "phosphoplipase", "A2", "IVA", "(", "C1418620#ent", "<e2>", ")", "and", "prostaglandin-endoperoxide", "synthase", "2", "PTGS2", ")", "expression", "in", "human", "amnion", "fibroblasts", "."], "h": {"id": "C4283933", "name": "C4283933#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418620", "name": "C1418620#ent", "pos": [13, 14]}}
{"token": ["OBQ", "reacts", "specifically", "with", "methionine", "residues", "of", "C0085431#ent", "<e1>", "highly", "C0815040#ent", "<e2>", "pH.", "At", "pH", "3", ",", "whereas", "C0085431#ent", "<e1>", "not", "react", ",", "RNAase", "S", "S-protein", "and", "S-peptide", "all", "react", "with", "OBQ", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085431", "name": "C0085431#ent", "pos": [7, 8]}}
{"token": ["Mutations", "in", "TSC1", "and", "C1860707#ent", "<e1>", "genes", "are", "the", "cause", "of", "an", "C3899989#ent", "<e2>", "as", "tuberous", "sclerosis", "complex", "TSC", ")", "."], "h": {"id": "C1860707", "name": "C1860707#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3899989", "name": "C3899989#ent", "pos": [12, 13]}}
{"token": ["C1860707#ent", "<e1>", "is", "a", "gene", "on", "chromosome", "16p13.3", "associated", "with", "C3899989#ent", "<e2>", "tuberous", "sclerosis", "complex", "TSC", ")", "."], "h": {"id": "C1860707", "name": "C1860707#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3899989", "name": "C3899989#ent", "pos": [10, 11]}}
{"token": ["beta-Galactosidase", "(", "Lac4p", ")", "activity", "was", "detected", "in", "transformants", "carrying", "an", "C2828542#ent", "<e1>", "fusion", "to", "the", "Kluyveromyces", "lactis", "LAC4", "gene", "while", "fusions", "to", "the", "Escherichia", "coli", "C1421976#ent", "<e2>", "to", "other", "heterologous", "genes", "were", "not", "expressed", "."], "h": {"id": "C2828542", "name": "C2828542#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [26, 27]}}
{"token": ["Partington", "et", "al.", "[", "1988", "]", "described", "a", "three-generation", "family", "(", "MRXS1", ",", "MIM", "*", "309510", ",", "C0796250#ent", "<e1>", ")", "with", "a", "C0012739#ent", "<e2>", "form", "of", "X-linked", "mental", "retardation", "XLMR", ")", "."], "h": {"id": "C0796250", "name": "C0796250#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [22, 23]}}
{"token": ["Mice", "were", "made", "physically", "dependent", "ethanol", "by", "a", "3-day", "C0001962#ent", "<e1>", "regimen", ",", "using", "C0034242#ent", "<e2>", "to", "stabilize", "blood", "ethanol", "concentrations", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034242", "name": "C0034242#ent", "pos": [14, 15]}}
{"token": ["Treatment", "of", "the", "latter", "C0001962#ent", "<e1>", "and", "thioacetanilide", "derivatives", "with", "hydrazonoyl", "chlorides", "afforded", "the", "corresponding", "C0034242#ent", "<e2>", "and", "1,3,4-thiadiazole", "derivatives"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034242", "name": "C0034242#ent", "pos": [15, 16]}}
{"token": ["Comparison", "of", "the", "deduced", "products", "both", "genes", "with", "proteins", "in", "databases", "showed", "similarities", "with", "C1333828#ent", "<e1>", "and", "C1259497#ent", "<e2>", "from", "different", "sources", ",", "including", "several", "C1333828#ent", "<e1>", "involved", "in", "sugar", "transfer", "during", "antibiotic", "biosynthesis"], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [14, 15]}}
{"token": ["Of", "the", "50", "C0015230#ent", "<e1>", "that", "increased", ",", "at", "least", "4", "C0015230#ent", "<e1>", "were", "inhibited", "in", "the", "presence", "of", "C0298346#ent", "<e1>", ",", "a", "MEK", "inhibitor", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0298346", "name": "C0298346#ent", "pos": [19, 20]}}
{"token": ["We", "also", "found", "that", "systemic", "C0011816#ent", "<e1>", "treatment", "results", "in", "upregulation", "of", "the", "anti-apoptotic", "gene", "MKP-1", "and", "downregulation", "of", "C1335191#ent", "<e2>", "Bid", "and", "TRAIL", "genes", "in", "tumor", "cells", "hours", "following", "C0011816#ent", "<e1>", "treatment", "."], "h": {"id": "C1335191", "name": "C1335191#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [5, 6]}}
{"token": ["The", "activities", "include", "phospholipase", "A", "lysophospholipase", "A", "glycerophospholipid", ":", "C0008380#ent", "<e1>", "lipase", ",", "protease", ",", "phosphatase", ",", "C0035541#ent", "<e2>", ",", "and", "p-nitrophenylphosphorylcholine", "(", "p-NPPC", ")", "hydrolase", "."], "h": {"id": "C0008380", "name": "C0008380#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [17, 18]}}
{"token": ["The", "selective", "C0040616#ent", "<e1>", "properties", "of", "etifoxine", "appear", "unrelated", "to", "an", "antagonist", "activity", "the", "C2698739#ent", "<e2>", "and", "CRF2", "receptors"], "h": {"id": "C0040616", "name": "C0040616#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2698739", "name": "C2698739#ent", "pos": [14, 15]}}
{"token": ["We", "suggest", "that", "the", "morphologic", "phenotype", "found", "in", "patients", "with", "C0033835#ent", "<e1>", ",", "also", "known", "as", "C3494506#ent", "<e2>", "has", "an", "associated", "risk", "spinal", "cord", "compression", "to", "congenital", "vertebral", "anomalies"], "h": {"id": "C0033835", "name": "C0033835#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C3494506", "name": "C3494506#ent", "pos": [16, 17]}}
{"token": ["C0033835#ent", "<e1>", ":", "Often", "in", "families", "with", "type", "Ia", "pseudohypoparathyroidism", "subjects", "with", "C3494506#ent", "<e2>", ",", "with", "no", "features", "of", "PTH", "resistance", ",", "are", "said", "to", "have", "pseudopseudohypoparathyroidism", "."], "h": {"id": "C0033835", "name": "C0033835#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C3494506", "name": "C3494506#ent", "pos": [12, 13]}}
{"token": ["This", "C0030956#ent", "<e1>", "became", "specifically", "cross-linked", "to", "C2697657#ent", "<e2>", ",", "and", "platelet", "stimulation", "enhanced", "its", "cross-linking", "to", "this", "alpha", "subunit"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2697657", "name": "C2697657#ent", "pos": [7, 8]}}
{"token": ["MDA-MB-231", "cells", "isolated", "from", "tumors", "exhibited", "profound", "differences", "in", "their", "enzyme", "activity", "compared", "with", "the", "parent", "cell", "line", "including", "the", "dramatic", "posttranscriptional", "up-regulation", "of", "the", "serine", "proteases", "urokinase", "plasminogen", "activator", "C0032143#ent", "<e1>", "down-regulation", "of", "the", "glycolytic", "C0162449#ent", "<e2>"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [30, 31]}, "relation": "NA", "t": {"id": "C0162449", "name": "C0162449#ent", "pos": [36, 37]}}
{"token": ["Further", ",", "omega-3", "eicosapentaenoic", "acid", "capable", "of", "down-regulating", "the", "production", "and", "effect", "of", "a", "number", "of", "mediators", "of", "C0006625#ent", "<e1>", ",", "such", "as", "IL-1", ",", "IL-6", ",", "C0812246#ent", "<e2>", "and", "proteolysis-inducing", "factor"], "h": {"id": "C0006625", "name": "C0006625#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [27, 28]}}
{"token": ["Some", "authors", "have", "also", "claimed", "that", "C0360396#ent", "<e1>", "smooth", "out", "blood", "glucose", "profiles", "in", "C0011854#ent", "<e2>", "but", "this", "is", "denied", "by", "others", "."], "h": {"id": "C0360396", "name": "C0360396#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [14, 15]}}
{"token": ["Two", "main", "classes", "of", "oral", "hypoglycaemic", "drugs", "the", "sulphonylureas", "and", "the", "C0360396#ent", "<e1>", ",", "are", "currently", "used", "in", "the", "therapy", "of", "type", "II", "C0011854#ent", "<e2>", "NIDDM", ")", "."], "h": {"id": "C0360396", "name": "C0360396#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [23, 24]}}
{"token": ["Serial", "iodination", "studies", "of", "four", "C0011608#ent", "<e1>", "patients", ",", "evaluated", "while", "taking", "C0010980#ent", "<e2>", "or", "sulfapyridine", ",", "showed", "inhibition", "of", "iodination", "by", "either", "drug", "."], "h": {"id": "C0011608", "name": "C0011608#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [12, 13]}}
{"token": ["All", "isolates", "exhibited", "AmpC", "C0221406#ent", "<e1>", "due", "to", "C1416427#ent", "<e2>", "mutation", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416427", "name": "C1416427#ent", "pos": [8, 9]}}
{"token": ["However", ",", "maturation", "of", "the", "C1428722#ent", "<e1>", "improved", "significantly", "when", "C0812281#ent", "<e2>", "concentration", "was", "reduced", "to", "150", "microM", "or", "C1428722#ent", "<e1>", "were", "co-inhibited", "with", "COCs", "."], "h": {"id": "C1428722", "name": "C1428722#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [10, 11]}}
{"token": ["A", "series", "of", "experiments", "has", "been", "performed", "in", "healthy", "male", "volunteers", "to", "investigate", "the", "disposition", "of", "orally", "administered", "C0069454#ent", "<e1>", "a", "potentially", "useful", "drug", "for", "the", "treatment", "of", "C0009324#ent", "<e2>"], "h": {"id": "C0069454", "name": "C0069454#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [28, 29]}}
{"token": ["The", "specific", "C3536879#ent", "<e1>", "nalorphine", "blocks", "the", "C0728960#ent", "<e2>", "does", "not", "diminish", "the", "hypoglycemic", "action", "."], "h": {"id": "C3536879", "name": "C3536879#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [7, 8]}}
{"token": ["This", "pharmacological", "effect", "blocked", "by", "prior", "treatment", "with", "the", "C3536879#ent", "<e1>", "naloxone", ",", "indicating", "that", "the", "potentiated", "C0728960#ent", "<e2>", "mediated", "by", "opioid-responsive", "neurons", "."], "h": {"id": "C3536879", "name": "C3536879#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [17, 18]}}
{"token": ["Postoperative", "C0025289#ent", "<e1>", "bacterial", "meningitis", "complicating", "the", "diagnosis", "until", "results", "of", "cerebrospinal", "fluid", "C3889436#ent", "<e2>", ")", "cultures", "can", "be", "obtained", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [13, 14]}}
{"token": ["Over", "a", "9-year", "period", ",", "children", "showing", "clinical", "and", "laboratory", "findings", "of", "C0025289#ent", "<e1>", "on", "the", "basis", "of", "their", "positive", "cultures", "blood", "or", "cerebro-spinal", "fluid", "C3889436#ent", "<e2>", ")", "for", "S.", "pneumoniae", "enrolled", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [25, 26]}}
{"token": ["The", "first", "gene", "product", "the", "papBA", "transcript", ",", "C0084110#ent", "<e1>", ",", "helps", "maintain", "the", "switch", "in", "the", "C1420342#ent", "<e2>", "state", "by", "activating", "papI", "transcription", "which", "in", "turn", "maintains", "Lrp", "binding", "sites", "4", "-", "6", "."], "h": {"id": "C0084110", "name": "C0084110#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [17, 18]}}
{"token": ["At", "this", "concentration", ",", "the", "release", "of", "the", "known", "granule", "enzymes", "reaches", "a", "maximum", ",", "but", "that", "of", "C3539768#ent", "<e1>", "not", "until", "10(-8", ")", "M", "C1333574#ent", "<e2>", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [25, 26]}}
{"token": ["Peripheral", "C2697656#ent", "<e1>", "also", "increases", "levels", "of", "plasma", "C3540778#ent", "<e2>", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [8, 9]}}
{"token": ["Whether", "the", "induction", "of", "IkappaBalpha", "mRNA", "in", "the", "brain", "after", "peripheral", "C2697656#ent", "<e1>", "injection", "is", "caused", "by", "the", "feedback", "action", "C3540778#ent", "<e2>", "has", "not", "been", "determined", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [20, 21]}}
{"token": ["Mutants", "of", "S.", "staphylolyticus", "were", "isolated", "and", "shown", "to", "have", "C2936489#ent", "<e1>", "the", "production", "of", "the", "three", "C3541394#ent", "<e2>", "."], "h": {"id": "C2936489", "name": "C2936489#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["Their", "siblings", ",", "heterozygous", "for", "C0752121#ent", "<e1>", "mutations", ",", "had", "C0220701#ent", "<e2>", "or", "without", "ataxia", "."], "h": {"id": "C0752121", "name": "C0752121#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [10, 11]}}
{"token": ["The", "resident", "assessment", "instrument", "C1335822#ent", "<e1>", ")", "consists", "of", "a", "minimum", "data", "set", "C3273937#ent", "<e2>", ")", "of", "elements", ",", "common", "definitions", ",", "and", "coding", "categories", "to", "perform", "a", "comprehensive", "assessment", "of", "a", "long", "term", "care", "facility", "resident", "."], "h": {"id": "C1335822", "name": "C1335822#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273937", "name": "C3273937#ent", "pos": [13, 14]}}
{"token": ["C0078569#ent", "<e1>", "is", "metabolized", "mainly", "by", "C3887685#ent", "<e2>", "to", "an", "active", "metabolite", "O-desmethylvenlafaxine", "(", "ODV", ")", "."], "h": {"id": "C0078569", "name": "C0078569#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [6, 7]}}
{"token": ["We", "studied", "the", "interaction", "of", "C0078569#ent", "<e1>", ",", "a", "new", "SSRI", ",", "with", "C3887685#ent", "<e2>", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0078569", "name": "C0078569#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [13, 14]}}
{"token": ["Thirty-three", "patients", "with", "depression", "treated", "with", "mg", "C0078569#ent", "<e1>", "were", "genotyped", "for", "the", "polymorphic", "enzyme", "debrisoquine", "4-hydroxylase", "C3887685#ent", "<e2>", ")", "."], "h": {"id": "C0078569", "name": "C0078569#ent", "pos": [7, 8]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [17, 18]}}
{"token": ["Similarly", ",", "a", "C1421567#ent", "<e1>", "T", "cells", "been", "shown", "to", "be", "a", "tyrosine", "kinase", "C1527940#ent", "<e2>", ")", "."], "h": {"id": "C1421567", "name": "C1421567#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1527940", "name": "C1527940#ent", "pos": [14, 15]}}
{"token": ["Among", "10", "cases", "of", "primary", "gastric", "cancer", "C1333589#ent", "<e1>", "was", "up-regulated", "in", "2", "cases", ",", "C1333584#ent", "<e2>", "and", "FZD8", "were", "up-regulated", "in", "4", "cases", "."], "h": {"id": "C1333589", "name": "C1333589#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333584", "name": "C1333584#ent", "pos": [15, 16]}}
{"token": ["C1412767#ent", "<e1>", "belongs", "to", "a", "novel", "family", "of", "highly", "conserved", "C0017337#ent", "<e2>", "."], "h": {"id": "C1412767", "name": "C1412767#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["The", "anti-cholinesterase", "effect", "MT", "was", "more", "intensive", "than", "that", "of", "C0038803#ent", "<e1>", ",", "bromopride", ",", "procainamide", "or", "C0033218#ent", "<e2>", ",", "but", "less", "pronounced", "than", "that", "of", "prostigmine", "."], "h": {"id": "C0038803", "name": "C0038803#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033218", "name": "C0033218#ent", "pos": [17, 18]}}
{"token": ["These", "human", "5", "'", "sequences", "are", "C1512488#ent", "<e1>", "to", "those", "found", "in", "rat", "brain", "and", "rabbit", "kidney", "C1333206#ent", "<e2>", "cDNAs", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333206", "name": "C1333206#ent", "pos": [17, 18]}}
{"token": ["Germline", "mutations", "the", "C1366530#ent", "<e1>", "FH", ",", "fumarase", ")", "C0079429#ent", "<e2>", "are", "found", "in", "the", "recessive", "FH", "deficiency", "syndrome", "and", "in", "dominantly", "inherited", "susceptibility", "to", "multiple", "cutaneous", "and", "uterine", "leiomyomatosis", "MCUL", ")", "."], "h": {"id": "C1366530", "name": "C1366530#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["Loss", "of", "function", "mutations", "in", "the", "C1366530#ent", "<e1>", "fumarase", ",", "FH", ")", "C0079429#ent", "<e2>", "were", "recently", "identified", "as", "the", "cause", "for", "dominantly", "inherited", "uterine", "and", "cutaneous", "leiomyomas", "and", "renal", "cell", "cancer"], "h": {"id": "C1366530", "name": "C1366530#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}}
{"token": ["Calcipotriol", "cream", "monotherapy", "is", "more", "effective", "than", "placebo", ",", "and", "as", "effective", "as", "betamethasone", "valerate", "cream", "C0009137#ent", "<e1>", "tar", "in", "C0033860#ent", "<e2>", "."], "h": {"id": "C0009137", "name": "C0009137#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [20, 21]}}
{"token": ["Exorex", "lotion", "is", "a", "novel", "formulation", "of", "prepared", "C0009137#ent", "<e1>", "tar", "indicated", "for", "the", "treatment", "of", "C0033860#ent", "<e2>", "."], "h": {"id": "C0009137", "name": "C0009137#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [16, 17]}}
{"token": ["This", "unusual", "cause", "of", "intravascular", "obstruction", "in", "C0263401#ent", "<e1>", "be", "considered", "in", "patients", "with", "C1565489#ent", "<e2>"], "h": {"id": "C0263401", "name": "C0263401#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [14, 15]}}
{"token": ["The", "clinical", "manifestations", "changing", "myalgia", ",", "peripheral", "ischaemia", "C0263401#ent", "<e1>", "episodic", "hypertension", "eosinophilia", "and", "rapidly", "progressive", "C1565489#ent", "<e2>"], "h": {"id": "C0263401", "name": "C0263401#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [16, 17]}}
{"token": ["The", "KATP", "channel", "composed", "of", "an", "inwardly", "rectifying", "potassium", "channel", "C1416578#ent", "<e1>", ",", "and", "the", "sulfonylurea", "receptor", "SUR", "1", ";", "in", "the", "C0771711#ent", "<e2>", "it", "is", "reported", "to", "be", "shared", "by", "all", "endocrine", "cell", "."], "h": {"id": "C1416578", "name": "C1416578#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [22, 23]}}
{"token": ["Higher", "levels", "of", "C1455836#ent", "<e1>", "beta", "I-ETA", "administration", "resulted", "in", "acute", "hemorrhagic", "necrosis", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C1455836", "name": "C1455836#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [14, 15]}}
{"token": ["SP600126", "greatly", "induced", "reactive", "oxygen", "species", "C0812281#ent", "<e1>", ")", "accumulation", ",", "while", "BSO", "and", "C0755562#ent", "<e2>", "had", "little", "or", "null", "effects"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "the", "C0812281#ent", "<e1>", "formation", "was", "inhibited", "by", "the", "Erk1/2", "pathway", "inhibitor", "C0755562#ent", "<e2>", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [13, 14]}}
{"token": ["An", "active", "site", "a", "Cys-X-X-Cys", "motif", "(", "C2987137#ent", "<e1>", ")", ",", "where", "X", "denotes", "any", "C2917660#ent", "<e2>", "is", "always", "found", "in", "the", "thiol-disulfide", "oxidoreductase", "superfamily"], "h": {"id": "C2987137", "name": "C2987137#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [15, 16]}}
{"token": ["Glycosylation", "reactions", "catalyzed", "by", "the", "catalytic", "action", "C1333828#ent", "<e1>", ",", "such", "as", "N-acetylglucosaminyltransferase", "III", "V", "and", "C0016790#ent", "<e2>", "etc", ".", ","], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0016790", "name": "C0016790#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "to", "the", "C1333828#ent", "<e1>", "encoded", "by", "the", "ABO", "genes", "several", "alpha-2", ",", "alpha-3", "and", "C0016790#ent", "<e2>", "are", "needed", "to", "account", "for", "the", "known", "ABH", "histo-blood", "group", "antigens"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0016790", "name": "C0016790#ent", "pos": [16, 17]}}
{"token": ["The", "main", "effect", "of", "C0020223#ent", "<e1>", "was", "a", "significant", "increase", "of", "C0376261#ent", "<e2>", ",", "which", "is", "consistent", "with", "reduction", "of", "tumor", "blood", "flow"], "h": {"id": "C0020223", "name": "C0020223#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [11, 12]}}
{"token": ["The", "pathogenic", "effects", "these", "Nef", "mutant", "C0002085#ent", "<e1>", "were", "evaluated", "in", "C1420709#ent", "<e2>", "mice", "by", "FACS", "analysis", "by", "histopathological", "assessment", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [11, 12]}}
{"token": ["Cisapride", "is", "the", "C1254351#ent", "<e1>", "of", "choice", "for", "treating", "delayed", "gastric", "emptying", "by", "erythromycin", "and", "C0034665#ent", "<e2>", "or", "nizatidine", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", "C1414086#ent", "<e1>", "is", "an", "unlikely", "candidate", "C0079429#ent", "<e2>", "for", "SRY-negative", "XX", "sex", "reversal", "in", "this", "model", "."], "h": {"id": "C1414086", "name": "C1414086#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}}
{"token": ["Recently", ",", "ionizing", "radiation", "been", "shown", "to", "enhance", "invasiveness", "of", "C1332416#ent", "<e1>", "tumor", "cells", "and", "several", "C1947941#ent", "<e2>", "including", "urokinase", "plasminogen", "activator", "uPA", ")", ",", "seem", "to", "be", "upregulated", "after", "radiation", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [16, 17]}}
{"token": ["Notably", ",", "they", "were", "sufficiently", "stable", "in", "vivo", "C1332416#ent", "<e1>", "attack", "from", "endogenous", "C1947941#ent", "<e2>", ",", "and", "maintained", "a", "homogeneous", ",", "non-aggregated", "form", "in", "vitro"], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [13, 14]}}
{"token": ["C0007570#ent", "<e1>", "a", "common", "C0019247#ent", "<e2>", "populations", "of", "Europe", "and", "the", "United", "States"], "h": {"id": "C0007570", "name": "C0007570#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [4, 5]}}
{"token": ["C0242430#ent", "<e1>", "effectively", "reduces", "radial", "artery", "RA", ")", "C0037763#ent", "<e2>", "in", "vitro", "but", "clinical", "data", "its", "use", "during", "coronary", "revascularization", "lacking", "."], "h": {"id": "C0242430", "name": "C0242430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037763", "name": "C0037763#ent", "pos": [8, 9]}}
{"token": ["Thrombin", "is", "a", "C2347702#ent", "<e1>", "acts", "as", "a", "C0026249#ent", "<e2>", "for", "several", "cell", "types", "its", "specific", "receptor", "."], "h": {"id": "C2347702", "name": "C2347702#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [8, 9]}}
{"token": ["Arthritis", "is", "a", "common", "manifestation", "of", "late", "Lyme", "disease", "can", "develop", "into", "an", "C3898123#ent", "<e1>", "histopathologic", "similarities", "to", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C3898123", "name": "C3898123#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [20, 21]}}
{"token": ["C0244989#ent", "<e1>", "GSK-3", ")", "is", "a", "C0072402#ent", "<e2>", "has", "recently", "emerged", "as", "a", "key", "target", "in", "drug", "discovery"], "h": {"id": "C0244989", "name": "C0244989#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [6, 7]}}
{"token": ["The", "similar", "phenomenon", "was", "observed", "in", "mononuclear", "cells", "from", "C1956346#ent", "<e1>", "CHD", ")", "patients", "who", "were", "receiving", "C0286651#ent", "<e2>", "treatment", "(", "20", "mg", "HS", ")", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [9, 10]}, "relation": "may_be_prevented_by", "t": {"id": "C0286651", "name": "C0286651#ent", "pos": [17, 18]}}
{"token": ["Clopidogrel", "also", "reduced", "platelet", "reactivity", "C1956346#ent", "<e1>", "patients", "with", "concurrent", "C0286651#ent", "<e2>", "medication", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0286651", "name": "C0286651#ent", "pos": [10, 11]}}
{"token": ["Following", "a", "4-weeks", "hypolipemiant-free", "baseline", "period", ",", "22", "patients-12", "with", "unstable", "angina", "UA", ")", "and", "10", "patients", "with", "stable", "C1956346#ent", "<e1>", "SCHD", ")", "-", "were", "treated", "with", "C0286651#ent", "<e2>", "20", "mg/day", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [19, 20]}, "relation": "may_be_prevented_by", "t": {"id": "C0286651", "name": "C0286651#ent", "pos": [27, 28]}}
{"token": ["We", "conclude", "that", "metabolism", "of", "ethanol", "to", "C0030438#ent", "<e1>", "via", "alcohol", "dehydrogenase", "not", "required", "for", "ethanol-mediated", "suppression", "of", "LPS-induced", "C1417760#ent", "<e2>", "transcription", "and", "TNFalpha", "synthesis/release", "in", "AM", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [19, 20]}}
{"token": ["C1419786#ent", "<e1>", "to", "an", "overexpression", "of", "C0399440#ent", "<e2>", "are", "associated", "with", "development", "of", "epithelial", "neoplasia", "invasive", "carcinoma"], "h": {"id": "C1419786", "name": "C1419786#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0399440", "name": "C0399440#ent", "pos": [6, 7]}}
{"token": ["To", "observe", "the", "effect", "of", "Folium", "Panax", "quinquefolium", "saponins", "(", "PQS", ")", "on", "apoptosis", "of", "cardiac", "muscle", "cells", "CMCs", ")", "and", "C1332664#ent", "<e1>", "in", "rats", "with", "acute", "myocardial", "infarction", "C0155626#ent", "<e2>", ")", "."], "h": {"id": "C1332664", "name": "C1332664#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [29, 30]}}
{"token": ["C0221406#ent", "<e1>", "of", "either", "proinflammatory", "cytokines", "C0003209#ent", "<e2>", "result", "in", "organ", "dysfunction"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003209", "name": "C0003209#ent", "pos": [6, 7]}}
{"token": ["In", "two", "patients", ",", "early", "discontinuation", "of", "C0006230#ent", "<e1>", "resulted", "in", "relapse", "of", "C0027849#ent", "<e2>", "which", "responded", "to", "reinstitution", "of", "the", "drug", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0027849", "name": "C0027849#ent", "pos": [13, 14]}}
{"token": ["These", "results", "do", "not", "indicate", "a", "useful", "role", "for", "dantrolene", "or", "C0006230#ent", "<e1>", "in", "the", "treatment", "of", "C0027849#ent", "<e2>", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0027849", "name": "C0027849#ent", "pos": [17, 18]}}
{"token": ["The", "use", "of", "dantrolene", "or", "C0006230#ent", "<e1>", "may", "hasten", "recovery", "from", "C0027849#ent", "<e2>", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0027849", "name": "C0027849#ent", "pos": [11, 12]}}
{"token": ["The", "CYP2D6", "phenotype", "was", "determined", "from", "the", "ratio", "of", "dextromethorphan", "conversion", "to", "C0011821#ent", "<e1>", "and", "the", "CYP2C19", "phenotype", "from", "the", "ratio", "of", "C0025381#ent", "<e2>", "and", "R-mephenytoin", "."], "h": {"id": "C0011821", "name": "C0011821#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0025381", "name": "C0025381#ent", "pos": [22, 23]}}
{"token": ["The", "current", "investigation", "was", "extended", "to", "study", "the", "level", "of", "the", "control", "mechanism", "C1333079#ent", "<e1>", "expression", "in", "normal", "corneal", "endothelial", "cells", "those", "modulated", "by", "corneal", "endothelium", "modulation", "factor", "by", "C0064833#ent", "<e2>"], "h": {"id": "C1333079", "name": "C1333079#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [29, 30]}}
{"token": ["Furthermore", ",", "inhibition", "of", "C2986464#ent", "<e1>", "observed", "with", "the", "administration", "of", "C0130137#ent", "<e2>", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0130137", "name": "C0130137#ent", "pos": [11, 12]}}
{"token": ["Distribution", "of", "the", "thiazide-sensitive", "NaCl", "cotransporter", "C0796137#ent", "<e1>", ")", ",", "calbindin", "D28", "K", "and", "C1567357#ent", "<e2>", "was", "examined", "by", "immunohistochemistry", ",", "and", "the", "content", "of", "rTSC1", "transcripts", "Northern", "blot", "in", "situ", "hybridization"], "h": {"id": "C0796137", "name": "C0796137#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1567357", "name": "C1567357#ent", "pos": [14, 15]}}
{"token": ["In", "patients", "with", "insulin-dependent", "diabetes", "mellitus", "IDDM", ")", "isolated", "peripheral", "airway", "involvement", "may", "give", "rise", "to", "inspiratory", "threshold", "load", "(", "C1366480#ent", "<e1>", ")", "contributing", "to", "C0013404#ent", "<e2>", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [25, 26]}}
{"token": ["We", "have", "made", "mutations", "in", "the", "predicted", "sixth", "C0021699#ent", "<e1>", "a", "rat", "C1332407#ent", "<e2>", "analyzed", "the", "variant", "proteins", "expressing", "them", "in", "COS-1", "cells"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332407", "name": "C1332407#ent", "pos": [12, 13]}}
{"token": ["C0018389#ent", "<e1>", "soybean", "water-soluble", "polysaccharide", ",", "or", "modified", "C0054259#ent", "<e2>", ",", "blended", "with", "maltodextrin", "were", "used", "as", "the", "wall", "materials"], "h": {"id": "C0018389", "name": "C0018389#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "the", "pharmacokinetic", "properties", "of", "artemether", "and", "C0531104#ent", "<e1>", "(", "AL", ")", "in", "pregnant", "women", "recrudescent", "uncomplicated", "multi-drug", "resistant", "falciparum", "C0024530#ent", "<e2>", "."], "h": {"id": "C0531104", "name": "C0531104#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "some", "of", "the", "biological", "effects", "C1709313#ent", "<e1>", "may", "include", "mediating", "the", "C0907533#ent", "<e2>", "activation", "of", "c-jun", ",", "which", "is", "important", "in", "transcriptional", "regulation", "oncogenic", "transformation"], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [13, 14]}}
{"token": ["The", "authors", "want", "to", "report", "the", "case", "because", "it", "is", "an", "example", "of", "an", "association", "between", "C0011168#ent", "<e1>", "retroperitoneal", "fibrosis", "the", "connective", "tissue", "disease", "for", "C0154162#ent", "<e2>", "and", "perhaps", ",", "aortic", "sclerosis"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0154162", "name": "C0154162#ent", "pos": [25, 26]}}
{"token": ["Heterogeneity", "of", "intestinal", "D-glucose", "transport", "demonstrated", "using", "pig", "jejunal", "brush-border", "membrane", "vesicles", "in", "the", "presence", "of", "100/0", "(", "out/in", ")", "mM", "gradients", "each", "of", "C3811061#ent", "<e1>", ",", "NaSCN", ",", "and", "C0071785#ent", "<e2>", "."], "h": {"id": "C3811061", "name": "C3811061#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0071785", "name": "C0071785#ent", "pos": [30, 31]}}
{"token": ["That", "contrasts", "with", "the", "findings", "of", "others", "who", "reported", "that", "most", "patients", "with", "severe", "hypertriglyceridemia", "associated", "with", "noninsulin-dependent", "diabetes", "mellitus", "NIDDM", ")", "(", "usually", "without", "C0022638#ent", "<e1>", ")", "did", "have", "coexisting", "C0020557#ent", "<e2>"], "h": {"id": "C0022638", "name": "C0022638#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [31, 32]}}
{"token": ["The", "C0086376#ent", "<e1>", "have", "been", "designated", "C3810538#ent", "<e2>", ",", "PL2", ",", "PL3", ",", "and", "PL4", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3810538", "name": "C3810538#ent", "pos": [6, 7]}}
{"token": ["Computational", "analysis", "the", "central", "region", "pSCL2", "revealed", "the", "presence", "of", "two", "open", "reading", "frames", "appear", "to", "encode", "C0086376#ent", "<e1>", "highly", "homologous", "to", "C3810538#ent", "<e2>", "and", "RepL2", ",", "replication", "proteins", "pSLA2-L", ",", "the", "large", "linear", "plasmid", "Streptomyces", "rochei"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3810538", "name": "C3810538#ent", "pos": [22, 23]}}
{"token": ["C1420863#ent", "<e1>", "and", "salusin-beta", "are", "C0536221#ent", "<e2>", "with", "hypotensive", "and", "bradycardic", "effects", "."], "h": {"id": "C1420863", "name": "C1420863#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [5, 6]}}
{"token": ["The", "10", "%", "C1413950#ent", "<e1>", "dust", "was", "less", "effective", ",", "the", "C0030756#ent", "<e2>", "in", "all", "three", "areas", "showing", "varying", "degrees", "of", "resistance", "."], "h": {"id": "C1413950", "name": "C1413950#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030756", "name": "C0030756#ent", "pos": [11, 12]}}
{"token": ["In", "all", "patients", "various", "C0740651#ent", "<e1>", "leukocytosis", ",", "acidosis", ",", "hyperlactatemia", ",", "C0268009#ent", "<e2>", ",", "renal", "failure", "and", ",", "finally", ",", "hemodynamic", "instability", "observed", "."], "h": {"id": "C0740651", "name": "C0740651#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268009", "name": "C0268009#ent", "pos": [12, 13]}}
{"token": ["Previous", "sensibilization", "of", "animals", "by", "LPS", "+", "C1414134#ent", "<e1>", ",", "treatment", "by", "indomethacin", ",", "C0010583#ent", "<e2>", "or", "syngeneic", "lymphocytes", "not", "augment", "the", "immunotherapeutic", "action", "LPS", "+", "C1414134#ent", "<e1>", "combination", "."], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [14, 15]}}
{"token": ["C1418858#ent", "<e1>", "and", "PP2A", "subunits", "be", "partially", "dissociated", "from", "C1826396#ent", "<e2>", "by", "high", "salt", "not", "by", "phosphatase", "inhibitors", "indicating", "that", "the", "interaction", "does", "not", "involve", "the", "catalytic", "site"], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826396", "name": "C1826396#ent", "pos": [9, 10]}}
{"token": ["The", "CSF/plasma", "concentration", "ratio", "of", "C3538683#ent", "<e1>", "6", "h", "after", "C0013227#ent", "<e2>", "was", "0.1", "."], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["Neutralization", "of", "virus", "entry", "infection", "by", "PI-3K", "other", "C1268567#ent", "<e1>", "a", "critical", "role", "for", "signaling", "molecules", "C3891713#ent", "<e2>", "infection", "of", "target", "cells"], "h": {"id": "C1268567", "name": "C1268567#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3891713", "name": "C3891713#ent", "pos": [16, 17]}}
{"token": ["C0017205#ent", "<e1>", "frequently", "associated", "with", "immunologic", "abnormalities", "e.g.", "hypergammaglobulinemia", ",", "C0272249#ent", "<e2>", "benign", "monoclonal", "gammopathy"], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0272249", "name": "C0272249#ent", "pos": [10, 11]}}
{"token": ["C0017205#ent", "<e1>", "in", "B", "cell", "and", "C0272249#ent", "<e2>", "which", "may", "have", "contributed", "to", "the", "hypergammaglobulinemia", "associated", "with", "idiopathic", "(", "\"", "autoimmune", "\"", ")", "chronic", "hepatitis", "this", "case", "."], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0272249", "name": "C0272249#ent", "pos": [6, 7]}}
{"token": ["The", "effects", "of", "UVA", "and", "C0033229#ent", "<e1>", "on", "the", "activity", "of", "C0020197#ent", "<e2>", "were", "investigated", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020197", "name": "C0020197#ent", "pos": [11, 12]}}
{"token": ["Studies", "of", "patients", "with", "PHN", "and", "C0019360#ent", "<e1>", "radicular", "pain", "rash", ")", "support", "the", "notion", "that", "low-grade", "C0085648#ent", "<e2>", "to", "pain", "."], "h": {"id": "C0019360", "name": "C0019360#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [17, 18]}}
{"token": ["C0019937#ent", "<e1>", "to", "be", "distinguished", "from", "C0036421#ent", "<e2>", "particular", "."], "h": {"id": "C0019937", "name": "C0019937#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [6, 7]}}
{"token": ["In", "the", "course", "of", "search", "for", "potent", "C0008142#ent", "<e1>", "inhibitors", "from", "plant", "extracts", ",", "the", "C0085387#ent", "<e2>", "O-methyl", "pisiferic", "acid", "8,20-dihydroxy-9(11),13-abietadien-12-one", "which", "have", "diterpene", "skeleton", "were", "isolated", "from", "the", "leaves", "of", "Chamaecyparis", "pisifera"], "h": {"id": "C0008142", "name": "C0008142#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [15, 16]}}
{"token": ["Salivation", "by", "the", "submandibular", "glands", "application", "of", "C0085196#ent", "<e1>", "was", "completely", "abolished", "by", "both", "prazosin", "and", "C0033497#ent", "<e2>", ",", "whereas", "salivation", "by", "the", "parotid", "glands", "completely", "abolished", "by", "C0033497#ent", "<e2>", "alone", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "long-term", "treatment", "with", "tacrine", "(", "C0039245#ent", "<e1>", ")", "was", "studied", "in", "three", "C0002395#ent", "<e2>", "patients", "(", "aged", "57", ",", "64", ",", "and", "68", "years", ")", "with", "mild", "dementia"], "h": {"id": "C0039245", "name": "C0039245#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [15, 16]}}
{"token": ["The", "therapeutical", "effects", "amiridin", "and", "C0039245#ent", "<e1>", "in", "treatment", "of", "C0002395#ent", "<e2>", "not", "related", "to", "their", "action", "on", "MAO-A", "and", "-B", "activity", "."], "h": {"id": "C0039245", "name": "C0039245#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [10, 11]}}
{"token": ["Tacrine", "(", "C0039245#ent", "<e1>", ")", "is", "an", "anticholinesterase", "drug", "to", "manage", "C0002395#ent", "<e2>", "but", "it", "is", "not", "clear", "how", "its", "chronic", "use", "might", "affect", "response", "to", "nondepolarizing", "muscle", "relaxants"], "h": {"id": "C0039245", "name": "C0039245#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [11, 12]}}
{"token": ["Some", "attention", "is", "paid", "to", "C0304512#ent", "<e1>", "additional", "pharmacological", "activities", "e.g.", ",", "labetalol", ",", "C0022616#ent", "<e2>", ",", "and", "urapidil", "."], "h": {"id": "C0304512", "name": "C0304512#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [14, 15]}}
{"token": ["Additional", "experiments", "indicated", "that", "tyrosine", "phosphorylation", "a", "C1332794#ent", "<e1>", "represent", "a", "general", "mechanism", "for", "G-protein", "coupled", "receptor", "C1366882#ent", "<e2>", "activation", "."], "h": {"id": "C1332794", "name": "C1332794#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [17, 18]}}
{"token": ["A", "12-year-old", "girl", "with", "C0747083#ent", "<e1>", "complicated", "by", "C0155448#ent", "<e2>", "and", "cerebellar", "abscess", "presented", "."], "h": {"id": "C0747083", "name": "C0747083#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155448", "name": "C0155448#ent", "pos": [8, 9]}}
{"token": ["This", "case", "report", "the", "use", "of", "Argatroban", ",", "an", "C0003280#ent", "<e1>", "and", "thrombin", "inhibitor", "treatment", "of", "C1839163#ent", "<e2>", "in", "an", "adult", "patient", "on", "extracorporeal", "membrane", "oxygenation", "ECMO", ")", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [16, 17]}}
{"token": ["Antiphospholipid", "syndrome", "characterized", "by", "the", "presence", "of", "high", "titers", "anti-beta(2)-glycoprotein", "I", "(", "beta(2)GPI)", "antibodies", "lupus", "C0003280#ent", "<e1>", "associated", "with", "thromboembolic", "phenomena", ",", "C1839163#ent", "<e2>", "and", "recurrent", "fetal", "loss", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [22, 23]}}
{"token": ["High", "serum", "levels", "of", "anticardiolipin", "antibodies", "systemic", "lupus", "erythematosus", "associated", "with", "circulating", "lupus", "C0003280#ent", "<e1>", ",", "false", "positive", "VDRL", "and", "the", "occurrence", "of", "thrombosis", ",", "C1839163#ent", "<e2>", "and", "recurrent", "abortions", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [25, 26]}}
{"token": ["As", "a", "model", "system", "we", "used", "C0960371#ent", "<e1>", "as", "the", "enzyme", "and", "BODIPY", "C0007332#ent", "<e2>", "the", "fluorogenic", "substrate"], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [13, 14]}}
{"token": ["Both", "CR", "1409", "and", "CR", "1505", "in", "a", "dose", "of", "5", "mg/kg/h", "suppressed", "the", "increases", "in", "pancreatic", "juice", "volume", "and", "both", "amylase", "and", "C0960371#ent", "<e1>", "outputs", "induced", "by", "C0007332#ent", "<e2>", "given", "intraduodenally", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [28, 29]}}
{"token": ["Peptic", "ulcer", "diarrhea", "of", "Zollinger-Ellison", "syndrome", "other", "acid", "hypersecretory", "states", "respond", "to", "cimetidine", "treatment", ",", "as", "may", "C0400807#ent", "<e1>", "steatorrhea", "of", "patients", "with", "C0030293#ent", "<e2>", "have", "a", "suboptimol", "response", "to", "oral", "pancreatin"], "h": {"id": "C0400807", "name": "C0400807#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030293", "name": "C0030293#ent", "pos": [23, 24]}}
{"token": ["For", "mammary", "adenocarcinoma", "xenografts", "resistant", "to", "C0085752#ent", "<e1>", ",", "MCF-7/Adr", ",", "superior", "therapeutic", "effects", "obtained", "with", "C0962559#ent", "<e2>", "compared", "with", "paclitaxel", "when", "i.p", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0962559", "name": "C0962559#ent", "pos": [16, 17]}}
{"token": ["C0949690#ent", "<e1>", "and", "soft", "tissue", "lesions", "were", "most", "commonly", "seen", "while", "C0683381#ent", "<e2>", "connective", "tissue", "disorders", "less", "commonly", "observed", "."], "h": {"id": "C0949690", "name": "C0949690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0683381", "name": "C0683381#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "lignans", "and", "spatiotemporal", "expression", "of", "AtPrR1", "and", "C3272732#ent", "<e1>", "in", "their", "functionally", "deficient", "A.", "thaliana", "mutants", "and", "C1883559#ent", "<e2>", "that", "both", "genes", "are", "involved", "in", "lariciresinol", "biosynthesis"], "h": {"id": "C3272732", "name": "C3272732#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [19, 20]}}
{"token": ["These", "C0599220#ent", "<e1>", "have", "been", "synthesized", "together", "as", "an", "intact", "C0210657#ent", "<e2>", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0210657", "name": "C0210657#ent", "pos": [10, 11]}}
{"token": ["The", "inhibition", "of", "C0051581#ent", "<e1>", "and", "esterase", "activities", "of", "C0005285#ent", "<e2>", "by", "antithrombin", "III", "also", "been", "demonstrated", "."], "h": {"id": "C0051581", "name": "C0051581#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005285", "name": "C0005285#ent", "pos": [9, 10]}}
{"token": ["Inhibition", "of", "the", "esterase", "and", "C0051581#ent", "<e1>", "activities", "of", "bovine", "alpha-", "and", "C0005285#ent", "<e2>", "in", "the", "presence", "of", "antithrombin", "III", "heparin", "has", "been", "studied", "."], "h": {"id": "C0051581", "name": "C0051581#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005285", "name": "C0005285#ent", "pos": [12, 13]}}
{"token": ["Baseline", "rates", "of", "responding", "during", "the", "FI", "and", "C1136365#ent", "<e1>", "generally", "higher", "than", "during", "the", "C0055288#ent", "<e2>", "and", "yoked-CFI", "components", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0055288", "name": "C0055288#ent", "pos": [15, 16]}}
{"token": ["C1424635#ent", "<e1>", "inhibits", "trypsin", "and", "elastase", "rapidly", ",", "and", "C1414504#ent", "<e2>", "and", "plasmin", "slowly", ",", "but", "is", "inactive", "for", "chymotrypsin", "and", "gland", "kallikrein"], "h": {"id": "C1424635", "name": "C1424635#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [9, 10]}}
{"token": ["Overall", ",", "brimonidine", "0.2", "%", "solution", "was", "well-tolerated", ",", "safe", "and", "clinically", "and", "statistically", "more", "effective", "than", "C0543470#ent", "<e1>", "0.25", "%", "suspension", "in", "lowering", "intraocular", "pressure", "patients", "with", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0543470", "name": "C0543470#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [28, 29]}}
{"token": ["Both", "prosaposin", "and", "C0529422#ent", "<e1>", "rapidly", "stimulated", "C0033681#ent", "<e2>", "phosphorylation", "in", "PC12", "cells", "increased", "phosphorylation", "of", "MAPK", "20-fold", "especially", "of", "p44", "MAPK", "peaked", "at", "5", "minutes", "of", "stimulation", "and", "then", "rapidly", "declined", "."], "h": {"id": "C0529422", "name": "C0529422#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [7, 8]}}
{"token": ["The", "C0030956#ent", "<e1>", "derived", "from", "post-translational", "processing", "C0674431#ent", "<e2>", "are", "produced", "in", "and", "act", "on", "areas", "of", "the", "autonomic", "nervous", "system", "for", "blood", "pressure", "regulation"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0674431", "name": "C0674431#ent", "pos": [7, 8]}}
{"token": ["Northern", "hybridization", "C1826843#ent", "<e1>", "cDNA", "probe", "that", "9L", "glioma", "cells", "endogenous", "C3539761#ent", "<e2>", "inhibitor", "mRNA", "."], "h": {"id": "C1826843", "name": "C1826843#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539761", "name": "C3539761#ent", "pos": [11, 12]}}
{"token": ["Virus-induced", "proliferation", "cerebrospinal", "fluid", "CSF", ")", "lymphocytes", "and", "blood", "lymphocytes", "studied", "in", "patients", "with", "C0025289#ent", "<e1>", "in", "patients", "with", "C0025290#ent", "<e2>", "other", "etiology", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0025290", "name": "C0025290#ent", "pos": [19, 20]}}
{"token": ["In", "summary", ",", "C0037707#ent", "<e1>", "is", "an", "efficacious", "C0003195#ent", "<e2>", "VPC", "suppression", ";", "in", "lower", "doses", "it", "is", "somewhat", "less", "effective", "but", "better", "tolerated", "."], "h": {"id": "C0037707", "name": "C0037707#ent", "pos": [3, 4]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "filamentous", "(", "F", ")", "actin", "on", "the", "channel-forming", "activity", "C0537536#ent", "<e1>", "SRE", ")", "in", "negatively", "charged", "and", "uncharged", "bilayer", "lipid", "membranes", "C1337098#ent", "<e2>", ")", "was", "studied", "."], "h": {"id": "C0537536", "name": "C0537536#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1337098", "name": "C1337098#ent", "pos": [24, 25]}}
{"token": ["It", "appears", "that", "the", "occurrence", "of", "multiple", "untranslated", "exons", "for", "C1522455#ent", "<e1>", "is", "a", "highly", "conserved", "theme", "for", "this", "C0079429#ent", "<e2>", "across", "species", "."], "h": {"id": "C1522455", "name": "C1522455#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "morphine", ",", "diazepam", "and", "three", "C0040615#ent", "<e1>", "chloropromazine", ",", "perphenazine", "and", "C0018546#ent", "<e2>", ")", "on", "neuronal", "firing", "rats", "were", "studied", "in", "the", "limbic", "system", "immobilized", "cats", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [8, 9]}, "relation": "therapeutic_class_of", "t": {"id": "C0018546", "name": "C0018546#ent", "pos": [14, 15]}}
{"token": ["Oncogenic", "osteomalacia", "or", "C0035579#ent", "<e1>", ",", "is", "an", "unusual", "clinicopathologic", "entity", "in", "which", "C3536983#ent", "<e2>", "osteomalacia", ",", "or", "C0035579#ent", "<e1>", ",", "occurs", "in", "association", "with", "some", "tumors", "of", "soft", "tissue", "bone", "."], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C3536983", "name": "C3536983#ent", "pos": [13, 14]}}
{"token": ["GAMS", "did", "not", "significantly", "change", "the", "onset", "pressures", "myoclonus", "or", "C0494475#ent", "<e1>", "but", "it", "caused", "the", "appearance", "of", "brief", "C0234535#ent", "<e2>", "to", "the", "onset", "of", "the", "HPNS", "."], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0234535", "name": "C0234535#ent", "pos": [19, 20]}}
{"token": ["Orally", "administered", "glycine", "(", "1.125", "g/kg", ")", "potentiated", "the", "anticonvulsant", "effect", "diazepam", "(", "DZP", ")", "to", "convert", "C0494475#ent", "<e1>", "less", "severe", "subthreshold", "C0234535#ent", "<e2>"], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0234535", "name": "C0234535#ent", "pos": [22, 23]}}
{"token": ["A", "predominance", "of", "generalised", "epilepsy", "seen", "with", "C0494475#ent", "<e1>", "32.9", "%", ")", "followed", "by", "C0234535#ent", "<e2>", "30.6", "%", ")", "and", "localisation", "related", "epilepsy", "(", "24.7", "%", ")", "."], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0234535", "name": "C0234535#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "a", "tetracycline-inducible", "expression", "model", "allowed", "us", "to", "confirm", "the", "central", "role", "of", "these", "C3539645#ent", "<e1>", "isoforms", "and", "the", "negative", "regulatory", "function", "C0080298#ent", "<e2>", "in", "the", "control", "of", "ST3", "expression", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [23, 24]}}
{"token": ["Finally", ",", "the", "activity", "of", "Src", "is", "negatively", "regulated", "by", "C3539645#ent", "<e1>", ",", "as", "shown", "by", "potentiation", "of", "C0080298#ent", "<e2>", "the", "presence", "of", "the", "C3539645#ent", "<e1>", "inhibitors", "GF109203X", "or", "Go6976", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [18, 19]}}
{"token": ["Activity", "of", "the", "activated", "C0027203#ent", "<e1>", "could", "not", "be", "further", "elevated", "by", "exogenous", "C0006784#ent", "<e2>", ",", "even", "after", "treatment", "of", "the", "membranes", "with", "glycodeoxycholate", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [13, 14]}}
{"token": ["C0021099#ent", "<e1>", "probably", "a", "variant", "of", "C0152081#ent", "<e2>", "may", "be", "provoked", "or", "precipitated", "by", "factors", ",", "such", "as", "pregnancy", "."], "h": {"id": "C0021099", "name": "C0021099#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0152081", "name": "C0152081#ent", "pos": [6, 7]}}
{"token": ["The", "C0021099#ent", "<e1>", "interpreted", "as", "a", "variant", "of", "the", "C0152081#ent", "<e2>", "during", "the", "pregnancy", "with", "lowered", "calcium-level", ",", "which", "increases", "the", "endogeneous", "eruption", "pressure", "."], "h": {"id": "C0021099", "name": "C0021099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0152081", "name": "C0152081#ent", "pos": [9, 10]}}
{"token": ["Report", "on", "a", "20", "years", "old", "pregnant", "woman", ",", "who", "fulfilled", "the", "criteria", "of", "the", "C0021099#ent", "<e1>", "well", "as", "later", "those", "of", "the", "C0152081#ent", "<e2>", "in", "her", "clinical", "course"], "h": {"id": "C0021099", "name": "C0021099#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0152081", "name": "C0152081#ent", "pos": [23, 24]}}
{"token": ["Mutant", "plants", "C0907533#ent", "<e1>", "activated", "expression", "of", "the", "C2986630#ent", "<e2>", "Myb", "factor", "gene", "which", "was", "identified", "as", "a", "positive", "regulator", "of", "tryptophan", "genes", "the", "atr", "mutant", "screen", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2986630", "name": "C2986630#ent", "pos": [8, 9]}}
{"token": ["Important", "are", "also", "enough", "C0740394#ent", "<e1>", "insulin", "and", "the", "level", "of", "C1334089#ent", "<e2>", "IGF", ")", "."], "h": {"id": "C0740394", "name": "C0740394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [11, 12]}}
{"token": ["Supportive", "measures", "to", "be", "considered", "to", "inhibit", "the", "highly", "active", "salvage", "C0020687#ent", "<e1>", "can", "partly", "antagonize", "a", "C0076656#ent", "<e2>", "induced", "decrease", "in", "guanine", "nucleotides"], "h": {"id": "C0020687", "name": "C0020687#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0076656", "name": "C0076656#ent", "pos": [17, 18]}}
{"token": ["Forty-two", "patients", "with", "longstanding", "C1527411#ent", "<e1>", "36", "patients", "with", "C0011849#ent", "<e2>", "had", "their", "blood", "viscosity", "measured", "."], "h": {"id": "C1527411", "name": "C1527411#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["After", "the", "acute", "stage", "C0015469#ent", "<e1>", "nerve", "degeneration", "find", "some", "signs", "of", "C0221166#ent", "<e2>", "after", "reinnervation", "due", "to", "insufficient", "motor", "recovery", "associated", "movements", "due", "to", "faulty", "reinnervation", "."], "h": {"id": "C0015469", "name": "C0015469#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221166", "name": "C0221166#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "transferring", "gp33-activated", "DN", "T", "cells", "inhibited", "the", "development", "of", "C0205734#ent", "<e1>", "suggesting", "that", "DN", "T", "cells", "provide", "a", "novel", "therapy", "for", "C0004364#ent", "<e2>"], "h": {"id": "C0205734", "name": "C0205734#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [23, 24]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "identify", "self", "antigens", "by", "serum", "autoantibodies", "unimmunized", "mice", "two", "strains", ":", "NOD", "mice", "prone", "to", "spontaneously", "develop", "C0205734#ent", "<e1>", "C57BL/6", "mice", "to", "be", "relatively", "resistant", "to", "C0004364#ent", "<e2>"], "h": {"id": "C0205734", "name": "C0205734#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [32, 33]}}
{"token": ["In", "patients", "with", "C0020443#ent", "<e1>", "the", "combination", "of", "atorvastatin", "and", "C0354648#ent", "<e2>", "tended", "to", "produce", "larger", "reductions", "in", "LDL-cholesterol", "levels", "and", "smaller", "reductions", "in", "triglyceride", "levels", "than", "atorvastatin", "monotherapy", "."], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0354648", "name": "C0354648#ent", "pos": [10, 11]}}
{"token": ["However", ",", "53", "%", "of", "the", "C1332416#ent", "<e1>", "embryos", "in", "the", "MT-I/II", "C1416746#ent", "<e2>", "morphologically", "abnormal", "compared", "to", "only", "32", "%", "of", "the", "embryos", "in", "the", "control", "mice"], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416746", "name": "C1416746#ent", "pos": [12, 13]}}
{"token": ["C0700478#ent", "<e1>", "does", "not", "improve", "C0033775#ent", "<e2>", "in", "hemodialysis", "patients", "."], "h": {"id": "C0700478", "name": "C0700478#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033775", "name": "C0033775#ent", "pos": [5, 6]}}
{"token": ["M2", "receptor", "binding", "reduced", "in", "the", "AP", "nucleus", "C1420508#ent", "<e1>", "compared", "with", "control", "subjects", "those", "with", "C0752347#ent", "<e2>"], "h": {"id": "C1420508", "name": "C1420508#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752347", "name": "C0752347#ent", "pos": [16, 17]}}
{"token": ["RNA", "was", "labeled", "with", "C0885449#ent", "<e1>", "in", "the", "reaction", "catalyzed", "with", "C1416903#ent", "<e2>", "(", "LP", ")", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416903", "name": "C1416903#ent", "pos": [11, 12]}}
{"token": ["DNA", "can", "be", "labeled", "with", "C0885449#ent", "<e1>", "in", "the", "reaction", "catalyzed", "with", "C1416903#ent", "<e2>", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416903", "name": "C1416903#ent", "pos": [12, 13]}}
{"token": ["The", "up-regulation", "of", "C3540579#ent", "<e1>", "responses", "by", "C0918027#ent", "<e2>", "may", "result", "in", "positive", "clinical", "responses"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0918027", "name": "C0918027#ent", "pos": [7, 8]}}
{"token": ["Analysis", "of", "known", "downstream", "effects", "of", "C1366499#ent", "<e1>", "showed", "NEP-expressing", "cells", "exhibiting", "decreased", "C0812228#ent", "<e2>", "and", "focal", "adhesion", "kinase", "phosphorylation", "and", "increased", "PTEN", "protein", "expression", "."], "h": {"id": "C1366499", "name": "C1366499#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [13, 14]}}
{"token": ["Phospholipase", "A2", "PLA2", ")", "stimulated", "PRL", "secretion", ",", "while", "the", "PLA2", "inhibitor", "C0034403#ent", "<e1>", "reduced", "both", "thyrotropin-releasing", "hormone", "TRH", ")", "and", "C1366646#ent", "<e2>", "VIP", ")", "stimulated", "PRL", "release", "."], "h": {"id": "C0034403", "name": "C0034403#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366646", "name": "C1366646#ent", "pos": [21, 22]}}
{"token": ["Three", "patients", "showing", "clinical", "and", "electrophysiological", "evidence", "of", "C0031117#ent", "<e1>", "suffered", "from", "the", "syndrome", "of", "\"", "C0030193#ent", "<e2>", "moving", "toes", "\"", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [16, 17]}}
{"token": ["Multifocal", "necrosis", "lymphoid", "follicles", "early", "as", "C1417406#ent", "<e1>", "4", "was", "seen", "in", "both", "C1825552#ent", "<e2>", "and", "2308", "infection", "."], "h": {"id": "C1417406", "name": "C1417406#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1825552", "name": "C1825552#ent", "pos": [13, 14]}}
{"token": ["Morbidity", "was", "confined", "to", "wound", "infection", "haematoma", ",", "C0476273#ent", "<e1>", "in", "one", "case", ",", "a", "C0376175#ent", "<e2>"], "h": {"id": "C0476273", "name": "C0476273#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0376175", "name": "C0376175#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", "poor", "gallbladder", "contractility", ",", "well-established", "as", "an", "etiologic", "factor", "animal", "models", "C0856727#ent", "<e1>", "is", "now", "linked", "to", "C0267842#ent", "<e2>", "an", "early", "stage", "human", "C0856727#ent", "<e1>"], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0267842", "name": "C0267842#ent", "pos": [20, 21]}}
{"token": ["Under", "analysis", "were", "results", "of", "polarization", "microscopy", "bile", "in", "111", "patients", "with", "C0856727#ent", "<e1>", ",", "8", "patients", "with", "C0267842#ent", "<e2>", "8", "practically", "healthy", "people", "."], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0267842", "name": "C0267842#ent", "pos": [18, 19]}}
{"token": ["Five", "patients", "without", "C0856727#ent", "<e1>", "had", "thick-walled", "gallbladders", "and", "were", "diagnosed", "as", "C0267842#ent", "<e2>"], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0267842", "name": "C0267842#ent", "pos": [12, 13]}}
{"token": ["Cell", "therapy", "C0162674#ent", "<e1>", "transplantation", "of", "either", "C1516876#ent", "<e2>", "modified", "autologous", "cells", "normal", "donor", "cells", "will", "be", "rejected", "unless", "the", "host", "is", "adequately", "immune", "suppressed"], "h": {"id": "C0162674", "name": "C0162674#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [7, 8]}}
{"token": ["guanethidine", ",", "bethanidine", ",", "methyldopa", ",", "clonidine", ",", "C0030557#ent", "<e1>", ",", "propranolol", ",", "hydrazaline", ",", "C0026196#ent", "<e2>", ",", "guancydine", ",", "diazoxide", "and", "sodium", "nitroprusside"], "h": {"id": "C0030557", "name": "C0030557#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026196", "name": "C0026196#ent", "pos": [15, 16]}}
{"token": ["Children", "who", "develop", "C0034152#ent", "<e1>", "neurologic", "features", "headache", "should", "be", "evaluated", "for", "sinovenous", "thrombosis", "a", "C0398623#ent", "<e2>"], "h": {"id": "C0034152", "name": "C0034152#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "Western", "immunoblot", "analysis", "C1419367#ent", "<e1>", "and", "rP30", "may", "be", "useful", "in", "discriminating", "dually", "C1417201#ent", "<e2>", "and", "HGE", "IFA-reactive", "sera", "."], "h": {"id": "C1419367", "name": "C1419367#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417201", "name": "C1417201#ent", "pos": [15, 16]}}
{"token": ["RS-61443", ",", "a", "C0209368#ent", "<e1>", "mycophenolic", "acid", "reversibly", "and", "non-competitively", "blocks", "inosin", "monophosphate", "dehydrogenase", "the", "key", "C0027203#ent", "<e2>", "in", "purine", "de", "novo", "synthesis", "."], "h": {"id": "C0209368", "name": "C0209368#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}}
{"token": ["Mizoribine", "and", "C0209368#ent", "<e1>", "antimetabolites", "that", "inhibit", "a", "key", "C0027203#ent", "<e2>", "in", "the", "de", "novo", "purine", "biosynthetic", "pathway"], "h": {"id": "C0209368", "name": "C0209368#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["This", "automated", "assay", "the", "concentration", "of", "the", "antidepressant", "fluoxetine", "C0162373#ent", "<e1>", ")", "and", "its", "active", "metabolite", "C0068987#ent", "<e2>", "in", "serum", "by", "reversed-phase", "HPLC", "with", "spectrophotometric", "detection"], "h": {"id": "C0162373", "name": "C0162373#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0068987", "name": "C0068987#ent", "pos": [16, 17]}}
{"token": ["The", "interactions", "between", "14", "-", "3", "-", "3", "and", "other", "signalling", "proteins", "such", "as", "C1706586#ent", "<e1>", "and", "KSR", "(", "C1825781#ent", "<e2>", "Ras", ")", ",", "occur", "in", "a", "phospho-specific", "manner", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1825781", "name": "C1825781#ent", "pos": [19, 20]}}
{"token": ["Accordingly", ",", "palmitate", "activated", "ERK", "by", "a", "process", "that", "was", "dependent", "on", "ceramide", "synthesis", "de", "novo", "C1706586#ent", "<e1>", ",", "but", "independent", "of", "C1825781#ent", "<e2>", "Ras", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1825781", "name": "C1825781#ent", "pos": [22, 23]}}
{"token": ["The", "synthesis", "and", "the", "study", "of", "the", "C0003404#ent", "<e1>", "various", "heterocyclic", "N-ethylacetates", "derived", "from", "substituted", "derivatives", "of", "C0137098#ent", "<e2>", ",", "benzimidazole", "and", "benzotriazole", "do", "not", "show", "antiparasitic", "property", "."], "h": {"id": "C0003404", "name": "C0003404#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0137098", "name": "C0137098#ent", "pos": [17, 18]}}
{"token": ["p21", "was", "previously", "shown", "to", "stimulate", "C1417708#ent", "<e1>", "transcriptional", "activity", "through", "its", "effect", "on", "the", "C1366462#ent", "<e2>", "transcription", "cofactor", "family"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366462", "name": "C1366462#ent", "pos": [15, 16]}}
{"token": ["Activation", "of", "transcription", "by", "C1417708#ent", "<e1>", "requires", "association", "with", "coactivator", "proteins", "including", "CBP/p300", "and", "C1366462#ent", "<e2>", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366462", "name": "C1366462#ent", "pos": [14, 15]}}
{"token": ["The", "Dmbbc1", "cDNA", "is", "62", "%", "identical", "to", "the", "human", "C1709821#ent", "<e1>", "cDNA", "within", "a", "conserved", "C1412821#ent", "<e2>", "the", "encoded", "proteins", "share", "74", "%", "sequence", "similarity"], "h": {"id": "C1709821", "name": "C1709821#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [16, 17]}}
{"token": ["C0005416#ent", "<e1>", "defined", "as", "symptomatic", "biliary", "colic", "C0856727#ent", "<e2>", ",", "and", "is", "diagnosed", "during", "cholescintigraphy", "by", "assessing", "gallbladder", "emptying", "cholecystokinin", "(", "CCK", ")", "stimulation", "."], "h": {"id": "C0005416", "name": "C0005416#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [7, 8]}}
{"token": ["Spinach", "C3179066#ent", "<e1>", "preparations", "were", "mixed", "with", "Clostridium", "kluyveri", "hydrogenase", "C1414571#ent", "<e2>", "."], "h": {"id": "C3179066", "name": "C3179066#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414571", "name": "C1414571#ent", "pos": [10, 11]}}
{"token": ["This", "enzyme", "is", "localized", "in", "plastids", ",", "including", "C3179066#ent", "<e1>", ",", "and", "uses", "C1414571#ent", "<e2>", "as", "an", "electron", "donor"], "h": {"id": "C3179066", "name": "C3179066#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414571", "name": "C1414571#ent", "pos": [13, 14]}}
{"token": ["Proton", "uptake", "by", "isolated", "C3179066#ent", "<e1>", "during", "cyclic", "electron", "transport", "the", "presence", "of", "C1414571#ent", "<e2>", "and", "under", "NADP+", "reduction", "from", "the", "ascorbate", "--", "TMPD", "donor", "pair", "under", "anaerobic", "conditions", "was", "studied", "."], "h": {"id": "C3179066", "name": "C3179066#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414571", "name": "C1414571#ent", "pos": [13, 14]}}
{"token": ["KM12C", "colon", "cancer", "cell", "expressing", "high", "(", "C1413029#ent", "<e1>", ")", "or", "negligible", "(", "C1824378#ent", "<e2>", ")", "levels", "of", "TGFalpha", "were", "implanted", "into", "the", "cecal", "walls", "nude", "mice"], "h": {"id": "C1413029", "name": "C1413029#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824378", "name": "C1824378#ent", "pos": [13, 14]}}
{"token": ["We", "show", "that", "C3811244#ent", "<e1>", "is", "a", "C0108471#ent", "<e2>", "and", "that", "the", "amino-terminal", "alpha-helix", "C3811244#ent", "<e1>", "is", "responsible", "for", "resistance", "to", "NHS", "."], "h": {"id": "C3811244", "name": "C3811244#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [7, 8]}}
{"token": ["CYP2C19", "and", "C1828468#ent", "<e1>", "catalyzed", "most", "efficiently", "the", "C0002586#ent", "<e2>", "N-demethylation", ",", "followed", "by", "CYP2C8", "and", "CYP2D6", "."], "h": {"id": "C1828468", "name": "C1828468#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002586", "name": "C0002586#ent", "pos": [8, 9]}}
{"token": ["Sixty-eight", "had", "condylomata", "acuminata", "14", "had", "C0275828#ent", "<e1>", "and", "31", "had", "cervical", "intraepithelial", "neoplasia", "or", "without", "C0281779#ent", "<e2>", "."], "h": {"id": "C0275828", "name": "C0275828#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0281779", "name": "C0281779#ent", "pos": [16, 17]}}
{"token": ["Treatment", "with", "the", "histone", "deacetylase", "HDAC", ")", "inhibitor", "trichostatin", "A", "TSA", ")", "and", "overexpression", "of", "C3539637#ent", "<e1>", "isoforms", "were", "used", "to", "assess", "the", "impact", "of", "acetylation", "status", "C1968833#ent", "<e2>", "and", "NF-kappa", "B", "element", "promoter", "activity"], "h": {"id": "C3539637", "name": "C3539637#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [27, 28]}}
{"token": ["The", "major", "representatives", "of", "such", "disorders", "are", "diabetes", "insipidus", "the", "C0039082#ent", "<e1>", "of", "inappropriate", "secretion", "of", "antidiuretic", "hormone", "SI", "C1706109#ent", "<e2>", ")", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706109", "name": "C1706109#ent", "pos": [19, 20]}}
{"token": ["C0020473#ent", "<e1>", "is", "a", "feature", "of", "C0017920#ent", "<e2>", "GSD-I", ")", "(", "Levy", "et", "al.", ")", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [6, 7]}}
{"token": ["Despite", "severe", "C0020473#ent", "<e1>", ",", "patients", "with", "glycogen", "storage", "disease", "type", "1a", "C0017920#ent", "<e2>", ")", "do", "not", "develop", "premature", "atherosclerosis"], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [12, 13]}}
{"token": ["LH-stimulated", "cyclic", "C4285220#ent", "<e1>", "levels", "were", "decreased", "by", "the", "addition", "of", "the", "C1415169#ent", "<e2>", "agonist", "."], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [12, 13]}}
{"token": ["An", "11-year-old", "boy", "with", "recurrent", "C0027697#ent", "<e1>", "due", "to", "tubulointerstitial", "nephritis", "associated", "with", "uveitis", "(", "C0039082#ent", "<e2>", "was", "treated", "with", "cyclosporin", "A", "CSA", ")", "to", "induce", "sustained", "remission", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [15, 16]}}
{"token": ["Fifty", "percent", "N2O", "strongly", "reduced", "C0020429#ent", "<e1>", "induced", "by", "a", "first", "inflammation", "and", "its", "enhancement", "by", "fentanyl", ",", "and", "prevented", "exaggerated", "C0020429#ent", "<e1>", "induced", "by", "second", "inflammatory", "pain", "C3538771#ent", "<e1>", "."], "h": {"id": "C0020429", "name": "C0020429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538771", "name": "C3538771#ent", "pos": [28, 29]}}
{"token": ["Restless", "legs", "syndrome", "a", "C0027765#ent", "<e1>", "can", "be", "treated", "with", "C0244821#ent", "<e2>", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0244821", "name": "C0244821#ent", "pos": [10, 11]}}
{"token": ["The", "C0014442#ent", "<e1>", "has", "high", "specific", "activity", "against", "tri-", ",", "di-", "and", "C0026481#ent", "<e2>", ",", "as", "well", "as", "cholesterol", "esters", "and", "is", "inhibited", "by", "millimolar", "NaF", ",", "and", "micromolar", "HgCl2", "and", "DFP", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026481", "name": "C0026481#ent", "pos": [12, 13]}}
{"token": ["Two", "patients", "developed", "C1141927#ent", "<e1>", "one", "each", "developed", "aspiration", "pneumonia", "C0036690#ent", "<e2>", ",", "deep", "vein", "thrombosis", "post-traumatic", "hydrocephalus"], "h": {"id": "C1141927", "name": "C1141927#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [10, 11]}}
{"token": ["The", "human", "C0966246#ent", "<e1>", "differs", "from", "the", "bovine", "C1418417#ent", "<e2>", "and", "rat", "PDE2A2", "proteins", "at", "the", "amino", "terminus", "but", "its", "amino-terminal", "sequence", "is", "identical", "to", "the", "bovine", "PDE2A3", "sequence", "."], "h": {"id": "C0966246", "name": "C0966246#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418417", "name": "C1418417#ent", "pos": [8, 9]}}
{"token": ["No", "effect", "found", "for", "vitamin", "C.", "Individuals", "possessing", "the", "C1738886#ent", "<e1>", "significantly", "better", "high", "frequency", "otoacoustic", "emissions", "compared", "to", "C0919534#ent", "<e2>", "null", "individuals", "."], "h": {"id": "C1738886", "name": "C1738886#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919534", "name": "C0919534#ent", "pos": [19, 20]}}
{"token": ["The", "mechanism", "and", "consequences", "of", "16q", "LOH", "are", "not", "known", ",", "but", "the", "C1422163#ent", "<e1>", "in", "band", "16q22", "is", "a", "candidate", "target", "C0079429#ent", "<e2>", "."], "h": {"id": "C1422163", "name": "C1422163#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [22, 23]}}
{"token": ["Areas", "of", "interest", "included", "the", "sensorimotor", "cortex", "SMC", ")", ",", "primary", "motor", "area", "M1", ")", ",", "primary", "sensory", "area", "C0879262#ent", "<e1>", ")", ",", "premotor", "cortex", "PMC", ")", "and", "supplementary", "motor", "area", "C0026847#ent", "<e2>", ")", "."], "h": {"id": "C0879262", "name": "C0879262#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [31, 32]}}
{"token": ["We", "report", "the", "case", "of", "a", "77-year-old", "diabetic", "patient", "who", "presented", "with", "dysphonia", "and", "C0011168#ent", "<e1>", "and", "had", "a", "C0271355#ent", "<e2>"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0271355", "name": "C0271355#ent", "pos": [19, 20]}}
{"token": ["These", "factors", "include", "components", "of", "DNA-dependent", "protein", "kinase", "DNA-PK", ")", ",", "namely", "C1335262#ent", "<e1>", "and", "the", "Ku", "heterodimer", "Ku70-Ku80", ",", "and", "C1337033#ent", "<e2>", "."], "h": {"id": "C1335262", "name": "C1335262#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1337033", "name": "C1337033#ent", "pos": [21, 22]}}
{"token": ["Two", "of", "these", "are", "components", "of", "the", "DNA-dependent", "protein", "kinase", "DNA-PK", ")", "and", "include", "Ku80", "and", "DNA-PK", "catalytic", "subunit", "C1335262#ent", "<e1>", ")", ";", "the", "third", ",", "C1337033#ent", "<e2>", ",", "is", "a", "protein", "of", "unknown", "function", "."], "h": {"id": "C1335262", "name": "C1335262#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1337033", "name": "C1337033#ent", "pos": [26, 27]}}
{"token": ["In", "vitro", "study", ",", "we", "compared", "effects", "of", "GS", "332", "on", "rat", "urinary", "bladder", "muscle", "contractility", "with", "those", "of", "C0008932#ent", "<e1>", "clenbuterol", ")", ",", "an", "C2936789#ent", "<e2>"], "h": {"id": "C0008932", "name": "C0008932#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2936789", "name": "C2936789#ent", "pos": [25, 26]}}
{"token": ["C0008932#ent", "<e1>", "is", "a", "long", "acting", "C2936789#ent", "<e2>", "in", "the", "treatment", "of", "pulmonary", "disorders"], "h": {"id": "C0008932", "name": "C0008932#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936789", "name": "C2936789#ent", "pos": [6, 7]}}
{"token": ["C0264353#ent", "<e1>", "has", "not", "previously", "been", "described", "in", "association", "with", "C0175778#ent", "<e2>"], "h": {"id": "C0264353", "name": "C0264353#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0175778", "name": "C0175778#ent", "pos": [10, 11]}}
{"token": ["C1259877#ent", "<e1>", "PKC", ")", "plays", "an", "important", "role", "in", "mediating", "ischemic", "preconditioning", "C3811118#ent", "<e2>", ")", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [12, 13]}}
{"token": ["Overexpression", "of", "FrzA", "inhibited", "the", "increase", "in", "GSK-3beta", "phosphorylation", "as", "well", "as", "C1259877#ent", "<e1>", "PKC", ")", "epsilon", "activation", "in", "transgenic", "mice", "C3811118#ent", "<e2>", "as", "compared", "with", "littermates", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [21, 22]}}
{"token": ["The", "present", "study", "reported", "the", "efficacy", "of", "antisense", "oligonucleotides", "for", "N-methyl-D-aspartate", "receptor", "one", "C1312754#ent", "<e1>", ")", "in", "reduction", "of", "C1457887#ent", "<e2>", "a", "rat", "parkinsonian", "model", ",", "the", "unilateral", "6-hydroxydopamine-lesioned", "rat", "."], "h": {"id": "C1312754", "name": "C1312754#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [19, 20]}}
{"token": ["The", "present", "data", "indicate", "that", "a", "single", "dose", "C1312754#ent", "<e1>", "antisense", "ameliorates", "C1457887#ent", "<e2>", "the", "rat", "model", "."], "h": {"id": "C1312754", "name": "C1312754#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [12, 13]}}
{"token": ["Oligoclonal", "IgG", "bands", "been", "reported", "in", "the", "cerebrospinal", "fluid", "CSF", ")", "from", "C1456687#ent", "<e1>", "patients", ",", "suggesting", "that", "the", "C0039082#ent", "<e2>", "is", "immune", "mediated", "or", "caused", "by", "persistent", "viral", "infection"], "h": {"id": "C1456687", "name": "C1456687#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [19, 20]}}
{"token": ["We", "suggest", "that", "C1337052#ent", "<e1>", "could", "contain", "some", "differentiating", "C0035064#ent", "<e2>", "that", "are", "able", "to", "potentiate", "NGF", "inducing", "neuronal", "differentiation", "PC12", "cells", "decreasing", "the", "cell", "proliferation"], "h": {"id": "C1337052", "name": "C1337052#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [9, 10]}}
{"token": ["Part", "of", "the", "C1705264#ent", "<e1>", "identical", "with", "the", "published", "data", "C1705264#ent", "<e1>", "."], "h": {"id": "C1705264", "name": "C1705264#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705264", "name": "C1705264#ent", "pos": [3, 4]}}
{"token": ["These", "findings", "suggest", "that", "our", "antibody", "recognizes", "C1705264#ent", "<e1>", "is", "useful", "for", "blocking", "HA", "binding", "to", "C1705264#ent", "<e1>", "."], "h": {"id": "C1705264", "name": "C1705264#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705264", "name": "C1705264#ent", "pos": [7, 8]}}
{"token": ["The", "inward", "current", "elicited", "by", "NMB", "or", "C1706574#ent", "<e1>", "was", "unaffected", "by", "K+", "channel", "blockade", "with", "external", "C1413246#ent", "<e2>", "+", "or", "by", "replacement", "of", "potassium", "gluconate", "the", "electrode", "solution", "caesium", "acetate"], "h": {"id": "C1706574", "name": "C1706574#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413246", "name": "C1413246#ent", "pos": [17, 18]}}
{"token": ["The", "C3814443#ent", "<e1>", "and", "VH4", "genes", "in", "combination", "with", "C0257694#ent", "<e2>", "harbored", "extensive", "somatic", "mutations", "."], "h": {"id": "C3814443", "name": "C3814443#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0257694", "name": "C0257694#ent", "pos": [9, 10]}}
{"token": ["The", "case", "of", "a", "20-year-old", "patient", ",", "affected", "by", "X-linked", "agammaglobulinaemia", "C0221026#ent", "<e1>", ")", ",", "who", "developed", "severe", "C0032285#ent", "<e2>", "from", "Pneumocystis", "jiroveci", "formerly", "Pneumocystis", "carinii", "(", "PCP", ")", ",", "is", "reported", "."], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [18, 19]}}
{"token": ["The", "case", "of", "a", "20-year-old", "patient", ",", "affected", "by", "C0221026#ent", "<e1>", "XLA", ")", ",", "who", "developed", "severe", "C0032285#ent", "<e2>", "from", "Pneumocystis", "jiroveci", "formerly", "Pneumocystis", "carinii", "(", "PCP", ")", ",", "is", "reported", "."], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [17, 18]}}
{"token": ["The", "most", "frequent", "stenosis", "was", "localized", "in", "oesophagogastric", "or", "C0028887#ent", "<e1>", "oesophagectomy", ",", "postcorrosive", "stenoses", "an", "those", "after", "C0677659#ent", "<e2>"], "h": {"id": "C0028887", "name": "C0028887#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0677659", "name": "C0677659#ent", "pos": [18, 19]}}
{"token": ["Results", "obtained", "showed", "that", "IGF-I", "stimulated", "KLF-6", "transcription", "in", "cells", "with", "normal", ",", "but", "not", "disrupted", ",", "C1705526#ent", "<e1>", ",", "suggesting", "that", "C1537486#ent", "<e2>", "is", "a", "downstream", "target", "for", "IGF-I", "action", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1537486", "name": "C1537486#ent", "pos": [22, 23]}}
{"token": ["Clinical", "signs", "C0578159#ent", "<e1>", "be", "limited", "to", "C0011991#ent", "<e2>", "however", ",", "evidence", "of", "colitis", "(", "fever", ",", "cramps", ",", "leukocytosis", ",", "fecal", "leukocytes", "suggests", "C.", "difficile", "infection"], "h": {"id": "C0578159", "name": "C0578159#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [7, 8]}}
{"token": ["The", "effects", "of", "morphine", "and", "C0030873#ent", "<e1>", "were", "antagonized", "by", "naloxone", "but", "not", "by", "C0004259#ent", "<e2>", ",", "while", "the", "effects", "of", "physostigmine", "were", "antagonized", "by", "C0004259#ent", "<e2>", "but", "not", "by", "naloxone", "."], "h": {"id": "C0030873", "name": "C0030873#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [14, 15]}}
{"token": ["This", "effect", "of", "C0030873#ent", "<e1>", "was", "not", "inhibited", "by", "either", "a", "combination", "of", "C0004259#ent", "<e2>", "and", "(+)-tubocurarine", ",", "or", "verapamil", ",", "in", "contrast", "to", "acetylcholine-induced", "catecholamine", "release", "."], "h": {"id": "C0030873", "name": "C0030873#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [13, 14]}}
{"token": ["This", "differential", "intrinsic", "apoptosis", "susceptibility", "of", "C1423842#ent", "<e1>", "effectors", "was", "found", "to", "be", "tightly", "regulated", "by", "C0376515#ent", "<e2>", "expression", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [16, 17]}}
{"token": ["C1969443#ent", "<e1>", "also", "inhibits", "the", "uptake", "C1951340#ent", "<e2>", "."], "h": {"id": "C1969443", "name": "C1969443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1951340", "name": "C1951340#ent", "pos": [6, 7]}}
{"token": ["A", "second", "component", ",", "related", "to", "the", "C0524620#ent", "<e1>", "may", "be", "principally", "genetic", "and", "associated", "with", "high", "C1420709#ent", "<e2>", ",", "low", "HDL", ",", "and", "LDL", "phenotype", "B", "in", "these", "Mexican", "children", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [17, 18]}}
{"token": ["No", "endothelial", "cell", "C1875400#ent", "<e1>", "expressed", "mRNA", "coding", "for", "acidic", "fibroblast", "growth", "factor", "C1332109#ent", "<e2>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332109", "name": "C1332109#ent", "pos": [13, 14]}}
{"token": ["Both", "omega-6", "and", "C1532673#ent", "<e1>", "long-chain", "polyunsaturated", "fatty", "acids", "LCPUFAs", ")", "modulate", "TH1", "and", "TH2", "cell", ",", "their", "C1333196#ent", "<e2>", "production", ",", "and", "cell", "proliferation", "thus", "may", "serve", "as", "endogenous", "anti-inflammatory", "molecules"], "h": {"id": "C1532673", "name": "C1532673#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [18, 19]}}
{"token": ["No", "increase", "in", "brain", "bilirubin", "brain", "albumin", "found", "in", "the", "group", "with", "metabolic", "acidosis", "but", "in", "the", "group", "with", "C0001127#ent", "<e1>", "bilirubin", "and", "C1412332#ent", "<e2>", "concentrations", "in", "the", "brain", "increased", "significantly", "."], "h": {"id": "C0001127", "name": "C0001127#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "that", "mevastatin", "inhibits", "cdk2", "activity", "in", "C1366526#ent", "<e1>", "the", "inhibition", "of", "Thr-160", "phosphorylation", "of", "C1332733#ent", "<e2>", ",", "providing", "a", "novel", "example", "of", "regulation", "of", "C1332733#ent", "<e2>", "at", "this", "level", "."], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332733", "name": "C1332733#ent", "pos": [17, 18]}}
{"token": ["Parallel", "to", "their", "effect", "on", "cell", "cycle", "ASA", "and", "C0021246#ent", "<e1>", "also", "reduced", "the", "levels", "of", "C0080054#ent", "<e2>", "and", "p33cdk2", ",", "two", "cyclin-dependent", "kinases", "are", "important", "for", "cell", "cycle", "progression", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [16, 17]}}
{"token": ["C1414314#ent", "<e1>", "also", "up-regulates", "the", "scaffold", "protein", "C1417024#ent", "<e2>", "JIP-1", ")", "."], "h": {"id": "C1414314", "name": "C1414314#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417024", "name": "C1417024#ent", "pos": [7, 8]}}
{"token": ["We", "describe", "a", "case", "of", "C0004030#ent", "<e1>", "was", "successfully", "treated", "with", "combination", "of", "C0935942#ent", "<e2>", "and", "voriconazole", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0935942", "name": "C0935942#ent", "pos": [13, 14]}}
{"token": ["It", "has", "recently", "been", "shown", "that", "adenoviral-mediated", "expression", "of", "C4054191#ent", "<e1>", "PGC-1", "alpha", "in", "hepatocytes", "stimulates", "C1428751#ent", "<e2>", "G6Pase", ")", "gene", "expression"], "h": {"id": "C4054191", "name": "C4054191#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1428751", "name": "C1428751#ent", "pos": [16, 17]}}
{"token": ["These", "proteins", "promote", "genome", "stability", "and", "mutations", "affecting", "human", "RecQ", "proteins", "underlie", "premature", "aging", "cancer", "predisposition", "syndromes", ",", "including", "C1337098#ent", "<e1>", "caused", "by", "mutations", "affecting", "the", "C1741784#ent", "<e2>"], "h": {"id": "C1337098", "name": "C1337098#ent", "pos": [19, 20]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1741784", "name": "C1741784#ent", "pos": [26, 27]}}
{"token": ["C1337098#ent", "<e1>", "an", "autosomal", "recessive", "disorder", "caused", "by", "mutations", "in", "the", "C1741784#ent", "<e2>"], "h": {"id": "C1337098", "name": "C1337098#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1741784", "name": "C1741784#ent", "pos": [11, 12]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "the", "reactivity", "of", "the", "sera", "from", "various", "types", "of", "pemphigus", "with", "C0034861#ent", "<e1>", "extracellular", "and", "intracellular", "domains", "of", "human", "C1414168#ent", "<e2>", "and", "Dsg3", "by", "immunoblot", "analysis"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414168", "name": "C1414168#ent", "pos": [26, 27]}}
{"token": ["An", "enzyme-linked", "immunosorbent", "assay", "ELISA", ")", "using", "C0034861#ent", "<e1>", "antigens", "did", "not", "show", "circulating", "autoantibodies", "against", "desmoglein", "1", "C1414168#ent", "<e2>", ")", "or", "desmoglein", "3", "Dsg3", ")", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414168", "name": "C1414168#ent", "pos": [18, 19]}}
{"token": ["The", "cardinal", "C0015411#ent", "<e1>", "mtDNA", "diseases", "are", "ophthalmoplegia", ",", "C0029132#ent", "<e2>", "and", "pigmentary", "retinopathy"], "h": {"id": "C0015411", "name": "C0015411#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029132", "name": "C0029132#ent", "pos": [9, 10]}}
{"token": ["C0015411#ent", "<e1>", "Lyme", "borreliose", "with", "unusual", "forms", "of", "conjunctivitis", ",", "keratitis", ",", "C0029132#ent", "<e2>", "uveitis", ",", "vitritis", "and", "rarely", "endophthalmitis", "."], "h": {"id": "C0015411", "name": "C0015411#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029132", "name": "C0029132#ent", "pos": [12, 13]}}
{"token": ["Mutation", "of", "most", "of", "the", "elements", "markedly", "decreased", "the", "expression", "of", "a", "C1522419#ent", "<e1>", "transfected", "into", "C1704920#ent", "<e2>", "thus", "documenting", "their", "functional", "importance", "for", "expression", "."], "h": {"id": "C1522419", "name": "C1522419#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704920", "name": "C1704920#ent", "pos": [16, 17]}}
{"token": ["These", "data", "suggest", "that", "TNF-alpha", "does", "not", "participate", "in", "the", "death", "of", "dopaminergic", "neurons", "C0242422#ent", "<e1>", "but", "that", "it", "slightly", "C2712370#ent", "<e2>", "dopamine", "metabolism", "the", "survival", "of", "dopaminergic", "terminals", "a", "mechanism", "involving", "both", "receptors", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [20, 21]}}
{"token": ["Recent", "research", "has", ",", "therefore", ",", "focused", "on", "finding", "new", "modes", "of", "therapy", "which", "will", "alleviate", "C0242422#ent", "<e1>", "symptoms", "without", "directly", "C2712370#ent", "<e2>", "neurotransmission", "in", "the", "striatum", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [21, 22]}}
{"token": ["Radiochemical", "and", "immunochemical", "data", "suggest", "a", "relationship", "of", "C3539618#ent", "<e1>", "with", "the", "pineal", "gland", "by", "interactions", "of", "this", "C0030956#ent", "<e2>", "with", "pineal", "functions", "as", "the", "serotonin", "N-acetyltransferase", "activity"], "h": {"id": "C3539618", "name": "C3539618#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}}
{"token": ["We", "also", "studied", "the", "effects", "of", "B1", "receptor", "agonist", "antagonist", ",", "a", "C3850105#ent", "<e1>", "and", "the", "C3536910#ent", "<e2>", "indomethacin", "."], "h": {"id": "C3850105", "name": "C3850105#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3536910", "name": "C3536910#ent", "pos": [16, 17]}}
{"token": ["The", "patients", "with", "C1271398#ent", "<e1>", "exhibited", "a", "high", "(", "97.1", "%", ")", "rate", "of", "C1698484#ent", "<e2>", "HP", "showing", "a", "high", "resistance", "to", "ABDs", "."], "h": {"id": "C1271398", "name": "C1271398#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1698484", "name": "C1698484#ent", "pos": [14, 15]}}
{"token": ["Transmembrane", "proteins", "C1418655#ent", "<e1>", "PLP", ")", ",", "the", "peripheral", "myelin", "protein", "22", "PMP-22", ")", "and", "C1417248#ent", "<e2>", "as", "well", "as", "myelin", "basic", "protein", "MBP", ")", "are", "crucial", "for", "this", "process", "."], "h": {"id": "C1418655", "name": "C1418655#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417248", "name": "C1417248#ent", "pos": [15, 16]}}
{"token": ["The", "successful", "use", "of", "C1337242#ent", "<e1>", "in", "dialysis", "patients", "and", "in", "patients", "with", "C0221002#ent", "<e2>", "prompted", "transplant", "physicians", "to", "use", "it", "to", "treat", "renal-transplant", "patients", "with", "persisting", "hyperparathyroidism", "."], "h": {"id": "C1337242", "name": "C1337242#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [13, 14]}}
{"token": ["C0010592#ent", "<e1>", "inhibits", "hypoxia-dependent", "gene", "transcription", "a", "reporter", "gene", "assay", "prevents", "the", "hypoxic", "accumulation", "of", "C1333897#ent", "<e2>", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "alpha", "3", "beta", "1", "keratinocyte", "adhesion", "C1416777#ent", "<e1>", "and", "plays", "a", "second", "role", "in", "ICA", "via", "C2323772#ent", "<e2>"], "h": {"id": "C1416777", "name": "C1416777#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2323772", "name": "C2323772#ent", "pos": [18, 19]}}
{"token": ["Longevity", "was", "greater", "during", "the", "second", "period", ",", "and", "a", "decrease", "in", "deaths", "due", "to", "C0038220#ent", "<e1>", "outweighed", "by", "an", "increase", "in", "deaths", "from", "C4025230#ent", "<e2>", "the", "larger", "number", "of", "older", "patients"], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4025230", "name": "C4025230#ent", "pos": [24, 25]}}
{"token": ["While", "the", "C0038826#ent", "<e1>", "of", "healed", "C0041330#ent", "<e2>", "lesions", "by", "Mycobacteria", "or", "Aspergillus", "species", "well", "documented", ",", "their", "coexistence", "is", "rare", "."], "h": {"id": "C0038826", "name": "C0038826#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041330", "name": "C0041330#ent", "pos": [6, 7]}}
{"token": ["Calcium", "entry", "SOCs", "induced", "by", "the", "calcium-ATPase", "inhibitor", "thapsigargin", "or", "the", "C0162757#ent", "<e1>", "carbachol", "inhibited", "C0018358#ent", "<e2>", "cGMP", "accumulation", "."], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018358", "name": "C0018358#ent", "pos": [15, 16]}}
{"token": ["Impairment", "of", "the", "human", "enzyme", "galactose-1-phosphate", "uridylyltransferase", "C0268151#ent", "<e1>", ")", "results", "in", "the", "C0016952#ent", "<e2>", "the", "biochemical", "basis", "of", "pathophysiology", "in", "galactosemia", "remains", "unknown", "."], "h": {"id": "C0268151", "name": "C0268151#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [13, 14]}}
{"token": ["Biochemical", "finding", "in", "one", "patient", "are", "consistent", "with", "presence", "of", "small", "amounts", "galactose-1-phosphate", "uridyltransferase", "C0268151#ent", "<e1>", ")", "activity", ",", "which", "differs", "from", "classical", "C0016952#ent", "<e2>", "."], "h": {"id": "C0268151", "name": "C0268151#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [23, 24]}}
{"token": ["The", "former", "group", "patients", "was", "designated", "as", "C0268151#ent", "<e1>", "GG", ")", "and", "the", "latter", "group", "as", "C0016952#ent", "<e2>", "GV", ")", "."], "h": {"id": "C0268151", "name": "C0268151#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [16, 17]}}
{"token": ["Nontoxic", "levels", "C0012582#ent", "<e1>", "enhanced", "the", "combined", "cytotoxicity", "of", "5-FU", "and", "C0733682#ent", "<e2>", "against", "B16", "melanoma", "human", "tumor", "cells", "in", "vitro", "measured", "by", "the", "succinate", "dehydrogenase", "inhibition", "SDI", ")", "test", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0733682", "name": "C0733682#ent", "pos": [11, 12]}}
{"token": ["The", "risk", "and", "benefits", "of", "tamoxifen", "must", "be", "carefully", "weighed", "and", "C0086132#ent", "<e1>", "be", "monitored", "and", "treated", "in", "women", "receiving", "C0039286#ent", "<e2>"], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "our", "experiments", "show", "that", "C1333931#ent", "<e1>", "can", "also", "enhance", "transactivation", "through", "the", "estrogen", "receptor", "C1366500#ent", "<e2>", "a", "ligand-dependent", "manner", ";", "thus", "identifying", "C1333931#ent", "<e1>", "as", "a", "nuclear", "hormone", "receptor", "coactivator"], "h": {"id": "C1333931", "name": "C1333931#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366500", "name": "C1366500#ent", "pos": [17, 18]}}
{"token": ["In", "conclusion", ",", "C1420426#ent", "<e1>", "and", "CS2", "may", "be", "responsible", "for", "the", "regulation", "of", "C1419007#ent", "<e2>", "and", "TCR/CD3", "through", "the", "stability", "of", "C1419007#ent", "<e2>", "mRNA", "in", "SLE", "T", "cells"], "h": {"id": "C1420426", "name": "C1420426#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419007", "name": "C1419007#ent", "pos": [14, 15]}}
{"token": ["Conversely", ",", "C1705628#ent", "<e1>", "loss", "deregulates", "the", "control", "of", "C3896756#ent", "<e2>", "expression", "."], "h": {"id": "C1705628", "name": "C1705628#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3896756", "name": "C3896756#ent", "pos": [9, 10]}}
{"token": ["FC", "and", "C3814419#ent", "<e1>", "appeared", "to", "be", "superior", "to", "the", "other", "C0991617#ent", "<e2>", "."], "h": {"id": "C3814419", "name": "C3814419#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [11, 12]}}
{"token": ["C3539565#ent", "<e1>", "cultured", "on", "FN", "substrate", "expressed", "C3889249#ent", "<e2>", ",", "Pax-6", ",", "insulin", "2", "glucagon", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889249", "name": "C3889249#ent", "pos": [7, 8]}}
{"token": ["In", "18", "dogs", ",", "C0018802#ent", "<e1>", "induced", "by", "constant", "infusion", "of", "the", "metabolic", "inhibitor", ",", "C0031404#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031404", "name": "C0031404#ent", "pos": [15, 16]}}
{"token": ["This", "study", "shows", "that", "C0054340#ent", "<e1>", "is", "an", "effective", "agent", "in", "the", "treatment", "of", "C0042109#ent", "<e2>", "suggests", "that", "C0054340#ent", "<e1>", "in", "the", "dose", "used", "lacks", "adverse", "effects", "such", "as", "drowsiness", ",", "traditionally", "associated", "with", "antihistamine", "therapy"], "h": {"id": "C0054340", "name": "C0054340#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [14, 15]}}
{"token": ["C1335851#ent", "<e1>", "BCSS", ")", "was", "significantly", "worse", "among", "the", "C1426958#ent", "<e2>", "cases", ":", "RR=2.0", "(", "95", "%", "CI=1.2", "-", "3.4", ";", "P=0.010", ")", "."], "h": {"id": "C1335851", "name": "C1335851#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1426958", "name": "C1426958#ent", "pos": [9, 10]}}
{"token": ["One", "in", "3", "patients", "with", "C0006840#ent", "<e1>", "complained", "of", "C0031350#ent", "<e2>", "hoarseness", ",", "but", "1", "in", "4", "patients", "without", "C0006840#ent", "<e1>", "had", "similar", "symptoms", "."], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [9, 10]}}
{"token": ["Salivary", "gland", "agenesis", "cause", "profound", "xerostomia", "in", "children", "and", "there", "may", "be", "oral", "and", "upper", "respiratory", "tract", "sequelae", ",", "such", "as", "dental", "caries", "C0006840#ent", "<e1>", ",", "ascending", "sialadenitis", "laryngitis", "and", "C0031350#ent", "<e2>", "."], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [30, 31]}}
{"token": ["While", "the", "C3659502#ent", "<e1>", "a", "low", "binding", "ability", ",", "malate", "and", "C1260230#ent", "<e2>", "been", "found", "to", "bind", "(NAD)2", "in", "a", "specific", "way", "with", "high", "affinity", "."], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1260230", "name": "C1260230#ent", "pos": [11, 12]}}
{"token": ["Induction", "of", "C0010762#ent", "<e1>", "IIB", "and", "IIE1", "by", "pretreatment", "of", "mice", "with", "C0031412#ent", "<e2>", ",", "3-methylcholanthrene", "or", "acetone", "had", "no", "significant", "effect", "on", "the", "toxicity", "of", "4-HA", "towards", "hepatocytes", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "C0010762#ent", "<e1>", "are", "slightly", "lower", "in", "C0031412#ent", "<e2>", "+", "dexamethasone", "treatment", "than", "in", "phenobarbitone-treated", "liver", "microsomes", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [9, 10]}}
{"token": ["Fascioliasis", "provoked", "decreases", "in", "aminopyrine", "N-demethylase", "aniline", "hydroxylase", "the", "mutagenic", "activity", "cyclophosphamide", "and", "C0010762#ent", "<e1>", "concentration", "in", "untreated", "or", "C0031412#ent", "<e2>", "or", "Arochlor", "pretreated", "rats", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [19, 20]}}
{"token": ["The", "neuronal", "C1332735#ent", "<e1>", "composed", "of", "the", "catalytic", "subunit", "C1565306#ent", "<e2>", "and", "the", "activator", "protein", "p35(nck5a", "or", "its", "isoform", ",", "p39(nck5ai", ")", "."], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1565306", "name": "C1565306#ent", "pos": [9, 10]}}
{"token": ["Treatment", "with", "elevated", "C0071766#ent", "<e1>", "+", "58", "mM", ")", "for", "5", "min", "increased", "C1420718#ent", "<e2>", "PS", "at", "each", "site", "in", "a", "Ca(2+)-dependent", "manner", "."], "h": {"id": "C0071766", "name": "C0071766#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "indicate", "that", "acidic", "domain", "C1333214#ent", "<e1>", "have", "a", "role", "in", "modulating", "both", "transcriptional", "regulation", "apoptosis", "through", "C0062773#ent", "<e2>", "inhibitory", "activity", "."], "h": {"id": "C1333214", "name": "C1333214#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [18, 19]}}
{"token": ["C0752224#ent", "<e1>", "and", "plasminogen", "activator", "PA", ")", "are", "C2717971#ent", "<e2>", "have", "been", "implicated", "in", "the", "ovulatory", "process"], "h": {"id": "C0752224", "name": "C0752224#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [8, 9]}}
{"token": ["We", "measured", "both", "the", "tissue", "concentration", "and", "the", "urinary", "excretion", "C0752224#ent", "<e1>", "(", "UKE", ")", ",", "a", "C2717971#ent", "<e2>", "synthesized", "and", "secreted", "in", "the", "distal", "connecting", "tubular", "cells", "."], "h": {"id": "C0752224", "name": "C0752224#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [17, 18]}}
{"token": ["E5gamma", "is", "present", "in", "group", "C1416273#ent", "<e1>", ",", "and", "E5delta", "is", "encoded", "in", "groups", "A1", "C3812180#ent", "<e2>", ",", "and", "C1416273#ent", "<e1>", ",", "which", "are", "associated", "with", "benign", "transformations", "."], "h": {"id": "C1416273", "name": "C1416273#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3812180", "name": "C3812180#ent", "pos": [15, 16]}}
{"token": ["Biliverdin", "IX", "lowered", "enzyme", "activity", "maximal", "C1422492#ent", "<e1>", "concentrations", "of", "YC-1", "and", "C0072497#ent", "<e2>", "PPIX", ")", "while", "it", "had", "no", "significant", "effect", "on", "the", "EC(50", ")", "values", "of", "these", "two", "NO", "independent", "activators", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072497", "name": "C0072497#ent", "pos": [12, 13]}}
{"token": ["We", "believe", "that", "long-term", "intermittent", "inhalation", "therapy", "C0025942#ent", "<e1>", "is", "well", "tolerated", "and", "useful", "in", "patients", "with", "C0004030#ent", "<e2>", ",", "particularly", "when", "systemic", "treatment", "difficult", "because", "of", "other", "underlying", "diseases", "or", "adverse", "reactions"], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [17, 18]}}
{"token": ["C0025942#ent", "<e1>", "was", "applied", "as", "feed", "additive", "for", "200", "with", "C0004030#ent", "<e2>", "infected", "geese", ",", "in", "a", "dosis", "of", "10", "mg", "of", "active", "substance", "one", "kg", "of", "body", "weight"], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [10, 11]}}
{"token": ["In", "C0022408#ent", "<e1>", "data", "obtained", "after", "two", "years", "of", "C0050559#ent", "<e2>", "treatment", "in", "20", "adult", "male", "patients", ",", "are", "reported", "."], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0050559", "name": "C0050559#ent", "pos": [9, 10]}}
{"token": ["To", "test", "the", "hypothesis", "that", "subthalamic", "nucleus", "C1705443#ent", "<e1>", ")", "stimulation", "in", "C0030567#ent", "<e2>", "PD", ")", "patients", "affects", "working", "memory", "response", "inhibition", "performance", ",", "particularly", "under", "conditions", "of", "high", "demand", "on", "cognitive", "control"], "h": {"id": "C1705443", "name": "C1705443#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [12, 13]}}
{"token": ["High-frequency", "stimulation", "the", "subthalamic", "nucleus", "C1705443#ent", "<e1>", ")", "is", "an", "effective", "treatment", "for", "advanced", "forms", "C0030567#ent", "<e2>"], "h": {"id": "C1705443", "name": "C1705443#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [15, 16]}}
{"token": ["CL", "316243", "increased", "the", "expression", "of", "UCP2", ",", "C1421315#ent", "<e1>", "and", "PGC-1", "in", "C1883559#ent", "<e2>", "."], "h": {"id": "C1421315", "name": "C1421315#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [13, 14]}}
{"token": ["The", "current", "study", "demonstrates", "that", "homogenates", "of", "Xenopus", "oocytes", "expressing", "C1366515#ent", "<e1>", "confer", "editing", "ability", "upon", "C3274824#ent", "<e2>", "extracts", "prepared", "from", "human", "liver", "when", "tested", "on", "a", "synthetic", "apoB", "RNA", "template", "in", "vitro"], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3274824", "name": "C3274824#ent", "pos": [16, 17]}}
{"token": ["Taken", "together", ",", "these", "data", "suggest", "that", "overexpression", "of", "C1705593#ent", "<e1>", "in", "the", "lung", "in", "the", "setting", "of", "established", "invasive", "C0004030#ent", "<e2>", "results", "in", "improved", "host", "defense", "and", "outcome", "of", "disease", "."], "h": {"id": "C1705593", "name": "C1705593#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [20, 21]}}
{"token": ["In", "five", "the", "decision", "was", "taken", "after", "failure", "by", "corticosteroids", "to", "control", "progressive", "C0022658#ent", "<e1>", "the", "face", "of", "unacceptable", "C3536709#ent", "<e2>", "toxicity", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [19, 20]}}
{"token": ["TNF-alpha", "and", "IL-1beta", "increased", "the", "expression", "of", "C1706544#ent", "<e1>", ",", "E-selectin", ",", "and", "VCAM-1", ",", "whereas", "C1334119#ent", "<e2>", "induced", "only", "that", "of", "VCAM-1", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334119", "name": "C1334119#ent", "pos": [16, 17]}}
{"token": ["The", "C0043194#ent", "<e1>", "WAS", ")", "is", "an", "C1279481#ent", "<e2>", "by", "mutations", "in", "the", "WASP", "gene"], "h": {"id": "C0043194", "name": "C0043194#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1279481", "name": "C1279481#ent", "pos": [7, 8]}}
{"token": ["For", "this", "purpose", "we", "assessed", "the", "functional", "activity", "of", "isolated", "PMN", "after", "in", "vivo", "treatment", "with", "C1823140#ent", "<e1>", "alone", "or", "in", "simultaneous", "treatment", "with", "Ru486", "(", "C1516869#ent", "<e2>", "."], "h": {"id": "C1823140", "name": "C1823140#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [26, 27]}}
{"token": ["Naloxone-induced", "C1705056#ent", "<e1>", "release", "may", "replace", "C0020615#ent", "<e2>", "of", "pituitary", "ACTH", "reserve", "humans", "."], "h": {"id": "C1705056", "name": "C1705056#ent", "pos": [1, 2]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [6, 7]}}
{"token": ["To", "investigate", "the", "role", "of", "C1705056#ent", "<e1>", "in", "the", "plasma", "ACTH", "response", "to", "C0020615#ent", "<e2>", ",", "two", "different", "doses", "of", "ovine", "CRH", "oCRH", ")", "were", "given", "to", "normal", "men", "during", "insulin-induced", "hypoglycemia"], "h": {"id": "C1705056", "name": "C1705056#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [13, 14]}}
{"token": ["In", "patients", "failing", "previous", "disease", "modifying", "C0003191#ent", "<e1>", "DMARD", ")", "therapy", ",", "both", "anakinra", "and", "C0717758#ent", "<e2>", "were", "significantly", "more", "effective", "than", "placebo", "."], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0717758", "name": "C0717758#ent", "pos": [15, 16]}}
{"token": ["Mouse", "C1425962#ent", "<e1>", "is", "a", "protein", "composed", "of", "376", "C3539947#ent", "<e2>"], "h": {"id": "C1425962", "name": "C1425962#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [9, 10]}}
{"token": ["The", "polypeptide", "backbones", "of", "the", "two", "molecules", "of", "C0073234#ent", "<e1>", "the", "asymmetric", "unit", "found", "to", "be", "statistically", "identical", "their", "differences", "from", "C0014241#ent", "<e2>", "be", "statistically", "insignificant"], "h": {"id": "C0073234", "name": "C0073234#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014241", "name": "C0014241#ent", "pos": [21, 22]}}
{"token": ["We", "recently", "utilized", "continuous", "infusion", "intravenous", "C0282210#ent", "<e1>", "in", "the", "treatment", "of", "respiratory", "failure", "an", "18-yr-old", "steroid-dependent", "C0004096#ent", "<e2>", "female", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}}
{"token": ["There", "is", "an", "overall", "inverse", "relationship", "between", "the", "level", "of", "C1705819#ent", "<e1>", "and", "the", "degree", "of", "C0002871#ent", "<e2>", "but", "a", "wide", "range", "of", "C1705819#ent", "<e1>", "response", "between", "patients", "with", "similar", "haemoglobin", "concentrations"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705819", "name": "C1705819#ent", "pos": [10, 11]}}
{"token": ["C1334126#ent", "<e1>", "is", "a", "C1332718#ent", "<e2>", "transduces", "intracellular", "signals", "in", "response", "to", "the", "chemokines", "interleukin-8", ",", "melanoma", "growth-stimulatory", "activity/growth-regulatory", "protein", ",", "and", "other", "ELR", "motif-containing", "CXC", "chemokines", "by", "coupling", "to", "heterotrimeric", "GTP-binding", "proteins"], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332718", "name": "C1332718#ent", "pos": [4, 5]}}
{"token": ["In", "contrast", "to", "C1364818#ent", "<e1>", ",", "prolonged", "decreases", "in", "NAPP", "levels", "occurred", "after", "C2700301#ent", "<e2>", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2700301", "name": "C2700301#ent", "pos": [13, 14]}}
{"token": ["Postoperative", "complication", "rate", "showed", "a", "recurrent", "C0262576#ent", "<e1>", "0", "in", "group", "I", "4", "%", "in", "group", "II", "a", "C0020626#ent", "<e2>", "of", "0", "in", "group", "I", "4", "%", "in", "group", "II"], "h": {"id": "C0262576", "name": "C0262576#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020626", "name": "C0020626#ent", "pos": [18, 19]}}
{"token": ["Clinically", "relevant", "mutations", "in", "patients", "with", "trichothiodystrophy", "(", "C1705972#ent", "<e1>", ")", "and", "Fanconi", "anemia", "disrupt", "the", "Fe-S", "clusters", "of", "C0268138#ent", "<e2>", "and", "FancJ", "and", "thereby", "abolish", "helicase", "activity"], "h": {"id": "C1705972", "name": "C1705972#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0268138", "name": "C0268138#ent", "pos": [19, 20]}}
{"token": ["Efficient", "integration", ",", "mRNA", "synthesis", "and", "protein", "expression", "the", "C1705972#ent", "<e1>", "obtained", "in", "all", "LXPDSN-transduced", "C0268138#ent", "<e2>", "fibroblasts", "tested", "."], "h": {"id": "C1705972", "name": "C1705972#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0268138", "name": "C0268138#ent", "pos": [15, 16]}}
{"token": ["Clearly", "the", "progression", "of", "iron", "loading", "C1623038#ent", "<e1>", "marks", "a", "crucial", "stage", "in", "the", "natural", "history", "a", "C0878681#ent", "<e2>", "therefore", "therapy", "and", "prognosis", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0878681", "name": "C0878681#ent", "pos": [17, 18]}}
{"token": ["Shc-SH2", ",", "an", "expression", "plasmid", "encoding", "the", "SH2", "domain", "C1705297#ent", "<e1>", ",", "attenuated", "shear", "stress", "of", "extracellular", "signal-regulated", "kinases", "C0380051#ent", "<e2>", "and", "the", "gene", "transcription", "by", "the", "activator", "protein-1/12-O-tetradecanoylphorbol-13-acetate-responsive", "element", "complex", "."], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [19, 20]}}
{"token": ["Forty", "patients", "with", "the", "unstable", "C0005686#ent", "<e1>", "been", "treated", "in", "a", "double-blind", "crossover", "trial", "of", "C0004609#ent", "<e2>", "5", "mg", "qds", "versus", "placebo", "."], "h": {"id": "C0005686", "name": "C0005686#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004609", "name": "C0004609#ent", "pos": [15, 16]}}
{"token": ["We", "prospectively", "studied", "the", "effect", "of", "C0037982#ent", "<e1>", ",", "an", "aldosterone", "antagonist", "on", "endothelial", "function", "patients", "with", "advanced", "congestive", "heart", "failure", "C0018802#ent", "<e2>", ")", "using", "the", "brachial", "artery", "reactivity", "method", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["We", "compared", "the", "rate", "of", "prescription", "of", "low-dose", "C0037982#ent", "<e1>", "among", "patients", "with", "C0018802#ent", "<e2>", "a", "general", "medical", "inpatient", "setting", "and", "in", "a", "specialist", "left", "ventricular", "(LV)", "dysfunction", "clinic", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["Two", "patients", ",", "one", "with", "C0004775#ent", "<e1>", "one", "with", "severe", "abuse", "of", "C0596110#ent", "<e2>", ",", "were", "investigated", "before", "and", "after", "indomethacin", "treatment", "."], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "this", "apparent", "case", "of", "C0004775#ent", "<e1>", "caused", "by", "long", "term", "C0596110#ent", "<e2>", "ingestion", "and", "suggest", "this", "may", "occur", "more", "frequently", "than", "is", "generally", "appreciated", "."], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "enhanced", "IHT", "induced", "SBP", "elevation", "after", "propranolol", "and", "dampened", "C3813197#ent", "<e1>", "reactivity", "after", "C0032912#ent", "<e2>", "suggest", "an", "overriding", "alpha", "stimulation", "SH", "subjects", "."], "h": {"id": "C3813197", "name": "C3813197#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "the", "effect", "of", "aminoguanidine", "(", "AG", ")", "on", "de", "novo", "interleukin", "1beta", "IL1beta", ")", ",", "nitric", "oxide", "NO", ")", ",", "and", "C1416402#ent", "<e1>", "IL1ra", ")", "production", "by", "C0949690#ent", "<e2>", "human", "synovial", "tissue", "articular", "cartilage", "cultures"], "h": {"id": "C1416402", "name": "C1416402#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [29, 30]}}
{"token": ["Chondrocyte-derived", "interleukin-1alpha", "interleukin-1beta", "may", "locally", "overwhelm", "inhibition", "by", "C1416402#ent", "<e1>", "promote", "the", "early", "degenerative", "changes", "in", "C0949690#ent", "<e2>", "."], "h": {"id": "C1416402", "name": "C1416402#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [16, 17]}}
{"token": ["Although", "C0772463#ent", "<e1>", "a", "step", "forward", "in", "the", "management", "of", "C0085681#ent", "<e2>", ",", "it", "has", "drawbacks", "and", "therefore", "is", "not", "the", "ideal", "phosphate", "binder"], "h": {"id": "C0772463", "name": "C0772463#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0085681", "name": "C0085681#ent", "pos": [10, 11]}}
{"token": ["C0039286#ent", "<e1>", "completely", "repressed", "C0669365#ent", "<e2>", "expression", "of", "c-jun", "in", "the", "uterine", "luminal", "cells", "by", "12", "h", "but", ",", "unlike", "estrogen", ",", "did", "not", "induce", "c-jun", "expression", "in", "the", "uterine", "myometrium", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [4, 5]}}
{"token": ["The", "previous", "studies", "demonstrated", "that", "C1515406#ent", "<e1>", "(", "TGF-beta(1", ")", ")", "could", "upregulate", "the", "expression", "of", "C0002003#ent", "<e2>", "AR", ")", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002003", "name": "C0002003#ent", "pos": [16, 17]}}
{"token": ["Malignant", "GISTs", "are", "more", "likely", "to", "be", "associated", "with", "positive", "C0812258#ent", "<e1>", "and", "p53", "phenotype", "and", "a", "negative", "C1705280#ent", "<e2>", "and", "p27(KIP1)", "phenotype", "."], "h": {"id": "C0812258", "name": "C0812258#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [18, 19]}}
{"token": ["As", "non-immune", "hydrops", "proportionately", "more", "common", ",", "radiologists", "should", "be", "aware", "that", "the", "diagnosis", "of", "\"", "C0020305#ent", "<e1>", "is", "not", "synonymous", "with", "\"", "C0272138#ent", "<e2>", "."], "h": {"id": "C0020305", "name": "C0020305#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0272138", "name": "C0272138#ent", "pos": [23, 24]}}
{"token": ["Their", "most", "unique", "feature", "is", "infection", "with", "the", "newly", "discovered", "human", "herpesvirus-8", "C3891713#ent", "<e1>", ";", "also", "known", "as", "Kaposi's", "sarcoma-associated", "herpesvirus", ",", "often", "accompanied", "by", "C4289590#ent", "<e2>", "with", "Epstein-Barr", "virus", "EBV", ")", "."], "h": {"id": "C3891713", "name": "C3891713#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4289590", "name": "C4289590#ent", "pos": [25, 26]}}
{"token": ["Our", "results", "show", "that", "Salmonella", "typhimurium", "porin", "bacterial", "C0175697#ent", "<e1>", "enhanced", "human", "and", "rabbit", "platelet", "aggregation", "induced", "by", "ADP", "and", "C1414504#ent", "<e2>", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [20, 21]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "effects", "of", "tetanus", "toxin", "Salmonella", "typhimurium", "porin", "and", "bacterial", "lipopolysaccharide", "C0175697#ent", "<e1>", ")", "on", "platelet", "aggregation", "induced", "by", "ADP", "and", "C1414504#ent", "<e2>", "in", "vitro"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [29, 30]}}
{"token": ["We", "therefore", "examined", "the", "expression", "of", "the", "C0919425#ent", "<e1>", "and", "found", "reduced", "levels", "of", "both", "C3252639#ent", "<e2>", "mRNA", "and", "CYP1A1-promoter", "controlled", "transcription", "resistant", "cells", "compared", "to", "the", "wild-type", "."], "h": {"id": "C0919425", "name": "C0919425#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3252639", "name": "C3252639#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "a", "44-year-old", "woman", "with", "CF", "associated", "with", "C0151449#ent", "<e1>", "SS", ")", ",", "who", "developed", "digital", "necrotic", "ulcerations", "and", "C0034150#ent", "<e2>", "of", "the", "lower", "legs"], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034150", "name": "C0034150#ent", "pos": [20, 21]}}
{"token": ["C0023788#ent", "<e1>", "WD", ")", "is", "a", "C1290884#ent", "<e2>", "infectious", "origin", "by", "Tropheryma", "whipplei", "TW", ")", "."], "h": {"id": "C0023788", "name": "C0023788#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [6, 7]}}
{"token": ["No", "expression", "of", "CD59", "was", "found", "on", "neurons", ",", "oligodendrocytes", "or", "blood", "vessels", "C0011880#ent", "<e1>", "brain", ",", "but", "this", "C3536859#ent", "<e2>", "present", "on", "these", "cells", "in", "the", "normal", "brain"], "h": {"id": "C0011880", "name": "C0011880#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3536859", "name": "C3536859#ent", "pos": [19, 20]}}
{"token": ["Haploinsufficiency", "of", "C1419771#ent", "<e1>", "in", "humans", "results", "in", "cleido-cranial", "dysplasia", "C0008928#ent", "<e2>", ")", ",", "characterized", "by", "supernumerary", "teeth", "in", "Runx2-/-", "mice", ",", "molar", "odontogenesis", "not", "proceed", "beyond", "the", "late", "bud", "stage"], "h": {"id": "C1419771", "name": "C1419771#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0008928", "name": "C0008928#ent", "pos": [10, 11]}}
{"token": ["Genetic", "studies", "mouse", "models", "asthma", "have", "identified", "interleukin-9", "(", "C1334127#ent", "<e1>", ")", "as", "a", "determining", "factor", "in", "controlling", "C0085129#ent", "<e2>", "a", "hallmark", "of", "the", "disease", "."], "h": {"id": "C1334127", "name": "C1334127#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085129", "name": "C0085129#ent", "pos": [18, 19]}}
{"token": ["Sequence", "analysis", "the", "human", "C1421350#ent", "<e1>", "cDNA", "showed", "that", "an", "C0079941#ent", "<e2>", "composed", "of", "1050", "amino", "acids", "a", "calculated", "MW", "of", "112.6", "kDa", "and", "a", "pI", "of", "8.80", "."], "h": {"id": "C1421350", "name": "C1421350#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [10, 11]}}
{"token": ["We", "demonstrate", "that", "C1538066#ent", "<e1>", "is", "a", "ubiquitous", "and", "C0907533#ent", "<e2>", "nuclear", "protein"], "h": {"id": "C1538066", "name": "C1538066#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}}
{"token": ["The", "reduction", "of", "avian", "oviduct", "C0086661#ent", "<e1>", "mRNA", "levels", "by", "C0011816#ent", "<e2>", "may", "play", "a", "role", "in", "glucocorticoid", "inhibition", "of", "cell", "proliferation", "this", "tissue", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [10, 11]}}
{"token": ["C0065767#ent", "<e1>", "is", "a", "vitamin", "D", "analog", "which", "has", "C0003392#ent", "<e2>", "and", "anti-", "inflammatory", "effects", "and", "stimulates", "terminal", "differentiation"], "h": {"id": "C0065767", "name": "C0065767#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [9, 10]}}
{"token": ["Five", "cases", "of", "nodular", "fasciitis", "three", "cases", "of", "C0432528#ent", "<e1>", "and", "one", "case", "of", "proliferative", "myositis", "investigated", "by", "C1412133#ent", "<e2>", "TRAP", ")", "histochemistry", "on", "conventional", "paraffin-embedded", "material"], "h": {"id": "C0432528", "name": "C0432528#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412133", "name": "C1412133#ent", "pos": [18, 19]}}
{"token": ["A", "comparative", "double-blind", "trial", "462", "patients", "with", "C0024031#ent", "<e1>", "osteoarthritic", "pain", "no", "difference", "efficacy", "between", "C0000970#ent", "<e2>", "325", "mg", "+", "tramadol", "37.5", "mg", "and", "C0000970#ent", "<e2>", "300", "mg", "+", "codeine", "30", "mg", "."], "h": {"id": "C0024031", "name": "C0024031#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [15, 16]}}
{"token": ["Using", "a", "series", "of", "chimeric", "constructs", "between", "C1416587#ent", "<e1>", "and", "a", "Gbetagamma-insensitive", "K+", "channel", ",", "C1416584#ent", "<e2>", ",", "we", "have", "identified", "a", "critical", "site", "interaction", "of", "GIRK", "with", "Gbetagamma", "."], "h": {"id": "C1416587", "name": "C1416587#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416584", "name": "C1416584#ent", "pos": [15, 16]}}
{"token": ["This", "article", "describes", "the", "development", "of", "the", "Sj\u00f6gren's", "Clinical", "Activity", "Index", "(", "C0064494#ent", "<e1>", ")", "for", "the", "measurement", "of", "systemic", "disease", "in", "patients", "with", "C1527336#ent", "<e2>", "PSS", ")", "."], "h": {"id": "C0064494", "name": "C0064494#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [24, 25]}}
{"token": ["This", "review", "gives", "an", "overview", "of", "autonomic", "dysfunction", "in", "C3890941#ent", "<e1>", "GBS", ")", "and", "C1417325#ent", "<e2>", "MS", ")", "."], "h": {"id": "C3890941", "name": "C3890941#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [14, 15]}}
{"token": ["C3890941#ent", "<e1>", "GBS", ")", ",", "chronic", "idiopathic", "demyelinating", "polyradiculoneuropathy", "CIDP", ")", ",", "and", "C1417325#ent", "<e2>", "MS", ")", "are", "disorders", "with", "presumed", "immunopathogenesis", "."], "h": {"id": "C3890941", "name": "C3890941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [13, 14]}}
{"token": ["The", "reaction", "exhibited", "a", "C4283936#ent", "<e1>", "and", "was", "not", "stimulate", "by", "several", "C0991617#ent", "<e2>", "previously", "shown", "to", "enhance", "base", "substitution", "mutagenesis", "during", "nitrous", "acid", "treatment", "of", "duplex", "deoxyribonucleic", "acid"], "h": {"id": "C4283936", "name": "C4283936#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [12, 13]}}
{"token": ["Infecting", "cardiomyocytes", "with", "adenoviruses", "that", "encode", "mutant", ",", "phosphorylation-resistant", "MKK6", "or", "C1366875#ent", "<e1>", "MAPK", "inhibited", "interleukin-1beta-induced", "C1705633#ent", "<e2>", "MAPK", "activation", ",", "COX-2", "gene", ",", "and", "PGE2", "release", "."], "h": {"id": "C1366875", "name": "C1366875#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [16, 17]}}
{"token": ["Training", "modified", "their", "muscle", "characteristics", ",", "C0795692#ent", "<e1>", "kinetics", "and", "the", "parameters", "of", "the", "C0036572#ent", "<e2>", "in", "the", "same", "direction", ",", "and", "proportions", "among", "the", "HT", "and", "the", "NT", "subjects", "."], "h": {"id": "C0795692", "name": "C0795692#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [14, 15]}}
{"token": ["C0795692#ent", "<e1>", "concentrations", "were", "elevated", "consistently", "in", "patients", "with", "partial", "C0036572#ent", "<e2>", "alone", "but", "were", "occasionally", "normal", "in", "children", "with", "spasms", "."], "h": {"id": "C0795692", "name": "C0795692#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}}
{"token": ["These", "segments", "are", "the", "third", "and", "fourth", "largest", "of", "the", "(", "ISAV", ")", "genome", "and", "may", "code", "for", "a", "nucleocapsid", "protein", "C1824810#ent", "<e1>", ")", "and", "a", "C1335439#ent", "<e2>", "(", "PA", ")", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [26, 27]}}
{"token": ["The", "C1824810#ent", "<e1>", ",", "matrix", ",", "and", "C1335439#ent", "<e2>", "(", "L", ")", "polypeptides", "were", "first", "detected", "associated", "with", "perinuclear", "membrane", "but", "were", "later", "distributed", "throughout", "the", "cytoplasm", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [7, 8]}}
{"token": ["The", "C1420805#ent", "<e1>", "order", "of", "potency", "of", "C1420563#ent", "<e2>", "was", "SP", "greater", "than", "neurokinin", "(", "NK", ")", "A", "greater", "than", "NKB", "."], "h": {"id": "C1420805", "name": "C1420805#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420563", "name": "C1420563#ent", "pos": [7, 8]}}
{"token": ["The", "C1420805#ent", "<e1>", "order", "of", "potency", "of", "tachykinins", "was", "SP", "greater", "than", "C1420563#ent", "<e2>", "(", "NK", ")", "A", "greater", "than", "NKB", "."], "h": {"id": "C1420805", "name": "C1420805#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420563", "name": "C1420563#ent", "pos": [12, 13]}}
{"token": ["There", "is", "a", "lack", "of", "agreement", "on", "the", "distribution", "of", "islet", "amyloid", "polypeptide", "C1415831#ent", "<e1>", ")", "in", "the", "C0030286#ent", "<e2>", "of", "healthy", "and", "diabetic", "subjects", "."], "h": {"id": "C1415831", "name": "C1415831#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030286", "name": "C0030286#ent", "pos": [18, 19]}}
{"token": ["C0002570#ent", "<e1>", "was", "immunolocalised", "to", "the", "apical", "membranes", "C0669372#ent", "<e2>", "and", "to", "the", "apical", "pole", "ductular", "and", "gall", "bladder", "mucosal", "cells"], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}}
{"token": ["A", "pharmacokinetic", "study", "C0060196#ent", "<e1>", "(", "Idrolone", ")", ",", "a", "C2266922#ent", "<e2>", "was", "conducted", "with", "single", "oral", "doses", "6", "healthy", "volunteers"], "h": {"id": "C0060196", "name": "C0060196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2266922", "name": "C2266922#ent", "pos": [10, 11]}}
{"token": ["The", "adrenocortical", "X-zone", "very", "poorly", "developed", "in", "young", "female", "mice", "homozygous", "for", "the", "C0020676#ent", "<e1>", ",", "hyt", ",", "mutation", ",", "Feeding", "the", "mice", "C0980712#ent", "<e2>", "in", "the", "development", "of", "an", "X-zone", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [13, 14]}, "relation": "may_be_prevented_by", "t": {"id": "C0980712", "name": "C0980712#ent", "pos": [23, 24]}}
{"token": ["Our", "aim", "was", "to", "investigate", "the", "efficacy", "of", "transdermal", "C1700683#ent", "<e1>", "in", "the", "treatment", "of", "C0035258#ent", "<e2>"], "h": {"id": "C1700683", "name": "C1700683#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0035258", "name": "C0035258#ent", "pos": [15, 16]}}
{"token": ["The", "C1861077#ent", "<e1>", "a", "rearranged", "form", "of", "the", "C0694890#ent", "<e2>", "has", "been", "found", "to", "be", "associated", "with", "human", "papillary", "thyroid", "carcinomas"], "h": {"id": "C1861077", "name": "C1861077#ent", "pos": [1, 2]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [8, 9]}}
{"token": ["It", "could", "be", "demonstrated", "that", "the", "C0020289#ent", "<e1>", "phosphatase", ",", "RNase", ",", "and", "C0014894#ent", "<e2>", "of", "the", "mitochondrial", "fraction", "contained", "in", "membrane-bound", "particles"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0014894", "name": "C0014894#ent", "pos": [13, 14]}}
{"token": ["Batten", "disease", "juvenile-onset", "neuronal", "ceroid", "lipofuscinosis", "JNCL", ")", ",", "the", "most", "common", "neurodegenerative", "disorder", "childhood", ",", "is", "caused", "by", "mutations", "in", "a", "recently", "identified", "gene", "(", "C0751383#ent", "<e1>", ")", "localized", "to", "C3697355#ent", "<e2>", "12.1", "."], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3697355", "name": "C3697355#ent", "pos": [31, 32]}}
{"token": ["A", "search", "for", "other", "synergistic", "(", "or", "antagonistic", ")", "microorganisms", "and", "determination", "of", "their", "mechanism(s", ")", "of", "action", "in", "C2712370#ent", "<e1>", "the", "progression", "of", "C0031381#ent", "<e2>", "is", "indicated", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [24, 25]}}
{"token": ["Mutations", "in", "the", "orphan", "nuclear", "receptor", "DAX1", "NR0B1", ")", "cause", "C0342482#ent", "<e1>", "AHC", ")", ",", "a", "disorder", "characterized", "by", "primary", "adrenal", "failure", "C0271623#ent", "<e2>"], "h": {"id": "C0342482", "name": "C0342482#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [22, 23]}}
{"token": ["Mutations", "in", "DAX1", "are", "responsible", "for", "C0342482#ent", "<e1>", "AHC", ")", "and", "C0271623#ent", "<e2>"], "h": {"id": "C0342482", "name": "C0342482#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [11, 12]}}
{"token": ["Titration", "of", "erythrocyte", "ghost", "membranes", "with", "CaM", "revealed", "a", "biphasic", "response", "C1706373#ent", "<e1>", "to", "this", "C1422492#ent", "<e2>", "."], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "the", "C1442514#ent", "<e1>", "Ets", ",", "as", "possible", "interaction", "proteins", "the", "coactivators", "SRC-1", "and", "C1334868#ent", "<e2>", "and", "the", "corepressor", "NCoR", "in", "human", "breast", "cancer"], "h": {"id": "C1442514", "name": "C1442514#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334868", "name": "C1334868#ent", "pos": [15, 16]}}
{"token": ["C0038233#ent", "<e1>", "activity", "is", "encoded", "by", "two", "highly", "homologous", "genes", "C1419846#ent", "<e2>", "and", "SCD2", ",", "which", "show", "tissue-specific", "expression", "and", "regulation", "."], "h": {"id": "C0038233", "name": "C0038233#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419846", "name": "C1419846#ent", "pos": [10, 11]}}
{"token": ["This", "case", "is", "unique", "because", "of", "the", "coexistence", "of", "C0020757#ent", "<e1>", "and", "psoriasiform", "skin", "changes", "in", "an", "adult", "with", "C0282102#ent", "<e2>"], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0282102", "name": "C0282102#ent", "pos": [19, 20]}}
{"token": ["Tyrosine", "phosphorylation", "C1335204#ent", "<e1>", "by", "the", "C0033681#ent", "<e2>", "increased", "the", "activity", "of", "C1335204#ent", "<e1>", "toward", "SGK", "and", "Akt", "."], "h": {"id": "C1335204", "name": "C1335204#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [6, 7]}}
{"token": ["In", "vitro", "C1335204#ent", "<e1>", "could", "be", "tyrosine-phosphorylated", "by", "both", "the", "c-Src", "and", "C0033681#ent", "<e2>"], "h": {"id": "C1335204", "name": "C1335204#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [12, 13]}}
{"token": ["Parathyroid", "hormone", "dibutyryl", "cyclic", "adenosine", "monophosphate", "AMP", ")", "decreased", "Tmp1", "substantially", ",", "whereas", "C0000981#ent", "<e1>", "inhibited", "P1", "reabsorption", "lower", "filtered", "C1418887#ent", "<e2>", "loads", "but", "did", "not", "diminish", "Tmp1", "."], "h": {"id": "C0000981", "name": "C0000981#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [20, 21]}}
{"token": ["The", "regulatory", "element", "found", "to", "contain", "an", "C1412821#ent", "<e1>", "231", "nucleotide", "residues", "showed", "95.2", "%", "homology", "with", "C1859592#ent", "<e2>", ",", "a", "functionally", "analogous", "regulatory", "gene", "E.", "coli", "J", "96", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1859592", "name": "C1859592#ent", "pos": [17, 18]}}
{"token": ["Ligand-induced", "desensitization", "of", "the", "epidermal", "growth", "factor", "receptor", "EGFR", ")", "is", "controlled", "by", "c-Cbl", ",", "a", "C0077678#ent", "<e1>", "binds", "multiple", "signaling", "proteins", ",", "including", "the", "C1333707#ent", "<e2>", "adaptor", "."], "h": {"id": "C0077678", "name": "C0077678#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333707", "name": "C1333707#ent", "pos": [25, 26]}}
{"token": ["In", "addition", ",", "C0143060#ent", "<e1>", "seen", "in", "cells", "situated", "at", "the", "top", "of", "C0032002#ent", "<e2>", "in", "a", "cone-shaped", "extension", "of", "the", "intermediate", "lobe"], "h": {"id": "C0143060", "name": "C0143060#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [13, 14]}}
{"token": ["Repeats", "13", "24", "are", "especially", "active", ",", "with", "known", "sites", "of", "interaction", "for", "the", "Na/K", "C1706373#ent", "<e1>", ",", "Cl/HCO(3", ")", "anion", "exchanger", ",", "voltage-gated", "sodium", "channel", "clathrin", "heavy", "chain", "C1416769#ent", "<e2>"], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1416769", "name": "C1416769#ent", "pos": [29, 30]}}
{"token": ["Neurodegenerative", "disorders", "including", "C0007758#ent", "<e1>", "SCA", ")", ",", "Huntington", "disease", "HD", ")", "and", "C0751781#ent", "<e2>", "DRPLA", ")", ",", "are", "associated", "with", "CAG", "repeats"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0751781", "name": "C0751781#ent", "pos": [13, 14]}}
{"token": ["Mean", "age", "onset", "in", "the", "SCA6", "patients", "is", "52", "years", ",", "which", "is", "much", "later", "than", "those", "reported", "for", "other", "autosomal", "dominant", "C0007758#ent", "<e1>", "including", "SCA1", ",", "SCA2", ",", "Machado-Joseph", "disease", "and", "C0751781#ent", "<e2>"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [22, 23]}, "relation": "manifestation_of", "t": {"id": "C0751781", "name": "C0751781#ent", "pos": [32, 33]}}
{"token": ["The", "reaction", "was", "dependent", "on", "both", "cosubstrates", "and", "active", "C0014442#ent", "<e1>", ",", "and", "the", "product", "of", "this", "C0001068#ent", "<e2>", "identified", "by", "radiochromatographic", "and", "GC-MS", "analysis", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001068", "name": "C0001068#ent", "pos": [17, 18]}}
{"token": ["The", "common", "causes", "of", "bleeding", "in", "this", "study", "were", "gastric", "and", "C0013295#ent", "<e1>", "gastritis", ",", "vascular", "malformations", "and", "C0267539#ent", "<e2>", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0267539", "name": "C0267539#ent", "pos": [18, 19]}}
{"token": ["Albumin", "inhibited", "deacylation", "of", "C3273549#ent", "<e1>", "and", "its", "conversion", "to", "PC", "by", "leukocytes", ",", "perhaps", "by", "binding", "the", "substrate", "(", "2", "moles", "of", "C3273549#ent", "<e1>", "per", "mole", "of", "C1412332#ent", "<e1>", ")", "."], "h": {"id": "C3273549", "name": "C3273549#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [28, 29]}}
{"token": ["The", "proteins", "GrlA", "and", "GrlB", "exhibit", "more", "than", "30", "%", "identity", "with", "E.", "coli", "C0209525#ent", "<e1>", "with", "the", "C0120543#ent", "<e2>", "S.", "aureus", "Escherichia", "coli"], "h": {"id": "C0209525", "name": "C0209525#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0120543", "name": "C0120543#ent", "pos": [18, 19]}}
{"token": ["GPD1", "(", "encoding", "C1414968#ent", "<e1>", "is", "a", "constitutively", "expressed", "C0079429#ent", "<e2>", "in", "Cochliobolus", "heterostrophus", "that", "produces", "a", "single", "transcript", "."], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["Complementary", "DNA", "synthesized", "from", "partially", "purified", "C1414968#ent", "<e1>", "was", "used", "as", "a", "hybridization", "probe", "cloning", "this", "C0079429#ent", "<e2>", "."], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["Enzymatic", "treatments", "C0025965#ent", "<e1>", "restriction", "endonucleases", "were", "used", "to", "probe", "the", "in", "vivo", "chromatin", "structure", "C1334468#ent", "<e2>", "."], "h": {"id": "C0025965", "name": "C0025965#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334468", "name": "C1334468#ent", "pos": [15, 16]}}
{"token": ["However", ",", "two", "other", "mood", "stabilizing", "C0006949#ent", "<e1>", "lamotrigine", "had", "no", "effect", "expression", "of", "GRP78", ",", "C1825546#ent", "<e2>", "or", "calreticulin", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1825546", "name": "C1825546#ent", "pos": [16, 17]}}
{"token": ["Loss", "of", "function", "the", "Na", ",", "K,2Cl-cotransporter", "(", "C1420090#ent", "<e1>", ")", "or", "of", "the", "C1422342#ent", "<e2>", "ENaC", ")", "reduces", "Na", "absorption", "thick", "ascending", "limbs", "collecting", "ducts", "."], "h": {"id": "C1420090", "name": "C1420090#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422342", "name": "C1422342#ent", "pos": [14, 15]}}
{"token": ["Verapamil", ",", "the", "first", "C0006684#ent", "<e1>", "be", "introduced", "for", "clinical", "use", "is", "a", "major", "C1254351#ent", "<e2>", "used", "for", "the", "treatment", "of", "systemic", "hypertension"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["Spike-like", "events", ",", "prolonged", "action", "potentials", "their", "afterhyperpolarizations", "were", "reduced", "in", "amplitude", "and", "duration", "when", "the", "C0006684#ent", "<e1>", "Co2+", "or", "blocking", "C1254351#ent", "<e2>", ",", "verapamil", ",", "was", "present", "in", "the", "bathing", "medium"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [21, 22]}}
{"token": ["The", "natriuresis", "observed", "during", "the", "C0006684#ent", "<e1>", "infusion", "suggests", "that", "this", "C1254351#ent", "<e2>", "may", "have", "a", "direct", "tubular", "effect", "on", "sodium", "reabsorption"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}}
{"token": ["The", "chloroquine", "resistance", "of", "Plasmodium", "falciparum", "reversed", "in", "vitro", "numerous", "compounds", ",", "including", "C0006684#ent", "<e1>", "which", "could", "enhance", "the", "accumulation", "of", "the", "C1254351#ent", "<e2>", "in", "the", "parasite", "food", "vacuole"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [22, 23]}}
{"token": ["This", "may", "include", "a", "continuous", "sequence", "C0001627#ent", "<e1>", "micronodular", "and", "C0342495#ent", "<e2>", "a", "unilateral", "adrenocortical", "adenoma", "even", "carcinoma", "."], "h": {"id": "C0001627", "name": "C0001627#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0342495", "name": "C0342495#ent", "pos": [10, 11]}}
{"token": ["Nine", "had", "C0001627#ent", "<e1>", "eight", "had", "adrenal", "neoplasms", "and", "one", "had", "C0342495#ent", "<e2>"], "h": {"id": "C0001627", "name": "C0001627#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0342495", "name": "C0342495#ent", "pos": [11, 12]}}
{"token": ["The", "voltage-sensitive", "calcium", "channel", "VSCC", ")", "C0001641#ent", "<e1>", ",", "nitrendipine", ",", "inhibited", "the", "CaCl(2)-induced", "increase", "in", "C1418938#ent", "<e2>", "mRNA", "without", "affecting", "cord", "formation"], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [16, 17]}}
{"token": ["C1859722#ent", "<e1>", "OMIM", "208085", ")", "is", "an", "autosomal", "recessive", "multisystem", "disorder", "by", "neurogenic", "arthrogryposis", "multiplex", "congenita", "C0015624#ent", "<e2>", "neonatal", "cholestasis", "with", "bile", "duct", "hypoplasia", "low", "gamma", "glutamyl", "transpeptidase", "gGT", ")", "activity", "."], "h": {"id": "C1859722", "name": "C1859722#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [16, 17]}}
{"token": ["We", "performed", "21", "liver", "biopsies", "1984", "and", "1997", "on", "patients", "with", "factor", "VIII", "C2732002#ent", "<e1>", ")", "or", "IX", "(", "FIX", ")", "deficiency", "and", "C0042974#ent", "<e2>", "VWD", ")", "."], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0042974", "name": "C0042974#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "one", "should", "look", "for", "C0747651#ent", "<e1>", "tuberculosis", ",", "foreign", "body", "aspiration", "tracheomalacia", ",", "C0264353#ent", "<e2>", ",", "cystic", "fibrosis", "."], "h": {"id": "C0747651", "name": "C0747651#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0264353", "name": "C0264353#ent", "pos": [15, 16]}}
{"token": ["The", "authors", "propose", "a", "promising", "new", "therapy", "for", "the", "treatment", "of", "C0151445#ent", "<e1>", "phenomenon", ",", "with", "C0205911#ent", "<e2>", "carbaprostacyclin", ")", "and", "a", "serotonergic", "S2-receptor", "antagonist", "ketanserin", ")", "given", "orally", "."], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [16, 17]}}
{"token": ["These", "studies", "demonstrate", "that", "there", "are", "multiple", "activation", "targets", "in", "RNA", "polymerase", "II", "that", "C1418743#ent", "<e1>", "and", "the", "C1442905#ent", "<e2>", "have", "similar", "roles", "in", "activation", "."], "h": {"id": "C1418743", "name": "C1418743#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1442905", "name": "C1442905#ent", "pos": [18, 19]}}
{"token": ["In", "cultured", "keratinocytes", "activation", "of", "the", "C1414313#ent", "<e1>", "upregulates", "expression", "of", "C1332397#ent", "<e2>", ")", ",", "an", "anti-apoptotic", "Bcl-2", "homolog"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [11, 12]}}
{"token": ["C0014544#ent", "<e1>", "more", "than", "15", "different", "epileptic", "syndromes", "e.g.", "West", "or", "C0238111#ent", "<e2>", "epilepsies", "with", "absences", ")", "can", "lead", "to", "the", "intraindividual", "manifestation", "of", "two", "or", "more", "seizure", "types", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [11, 12]}}
{"token": ["While", "investigating", "this", "seeming", "contradiction", ",", "we", "identified", "two", "distinct", "Arabidopsis", "thaliana", "genes", "encoding", "C1710596#ent", "<e1>", ",", "in", "contrast", "to", "previous", "reports", "of", "only", "one", "C0079429#ent", "<e2>", "in", "angiosperms", "."], "h": {"id": "C1710596", "name": "C1710596#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [25, 26]}}
{"token": ["Observations", "that", "C0066447#ent", "<e1>", ",", "prostaglandin", "synthesis", "inhibitors", ",", "and", "C0001645#ent", "<e2>", "with", "the", "initiation", "of", "normal", "feedback", "responses", "suggest", "that", "the", "vascular", "reaction", "caused", "by", "a", "complex", "system", "interdependent", "components", "."], "h": {"id": "C0066447", "name": "C0066447#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [10, 11]}}
{"token": ["C0066447#ent", "<e1>", "inhibited", "the", "purine", "action", ",", "but", "C0001645#ent", "<e2>", "dipyridamole", "did", "not", "."], "h": {"id": "C0066447", "name": "C0066447#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [8, 9]}}
{"token": ["Two", "tourists", "from", "Kenya", "with", "falciparum", "C0024530#ent", "<e1>", "had", "an", "R1-resistance", "against", "C0008269#ent", "<e2>", "(", "WHO-extended", "field", "test", ",", "no", "in-vitro", "test", ")", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [12, 13]}}
{"token": ["Prophylaxis", "against", "C0024530#ent", "<e1>", "had", "been", "carried", "out", "with", "C0008269#ent", "<e2>", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [2, 3]}, "relation": "may_be_prevented_by", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [9, 10]}}
{"token": ["Most", "of", "the", "phosphopeptides", "derived", "from", "C1413804#ent", "<e1>", "phosphorylated", "in", "vivo", "the", "same", "as", "those", "derived", "from", "C1413804#ent", "<e1>", "phosphorylated", "by", "C0033634#ent", "<e1>", "in", "vitro"], "h": {"id": "C1413804", "name": "C1413804#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [21, 22]}}
{"token": ["Greater", "stability", "and", "less", "susceptibility", "to", "proteolysis", "of", "the", "excess", "C0544483#ent", "<e1>", "formed", "in", "C0005283#ent", "<e2>", "may", "explain", "our", "findings", "."], "h": {"id": "C0544483", "name": "C0544483#ent", "pos": [10, 11]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [14, 15]}}
{"token": ["After", "incubation", "of", "reticulocytes", "with", "radioactive", "amino", "acid", "the", "specific", "activity", "of", "the", "C0544483#ent", "<e1>", "the", "blood", "of", "patients", "with", "C0005283#ent", "<e2>", "was", "consistently", "lower", "than", "that", "of", "the", "alpha-chain", "."], "h": {"id": "C0544483", "name": "C0544483#ent", "pos": [13, 14]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [20, 21]}}
{"token": ["Newly", "formed", "extracellular", "matrix", "stabilized", "by", "the", "C0014442#ent", "<e1>", ",", "tissue", "transglutaminase", "which", "we", "demonstrated", "to", "be", "overexpressed", "by", "C1854310#ent", "<e2>", "fibroblasts", "in", "vivo", "in", "vitro"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1854310", "name": "C1854310#ent", "pos": [19, 20]}}
{"token": ["During", "the", "present", "study", ",", "two", "additional", "effects", "of", "malate", "dehydrogenase", "investigated", ";", "they", "are", "evident", "only", "if", "the", "C0024544#ent", "<e1>", "allowed", "to", "reach", "equilibrium", "prior", "to", "initiating", "the", "C4283949#ent", "<e2>"], "h": {"id": "C0024544", "name": "C0024544#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4283949", "name": "C4283949#ent", "pos": [29, 30]}}
{"token": ["Successful", "treatment", "of", "C0085417#ent", "<e1>", "and", "the", "C4281785#ent", "<e2>", "in", "general", ")", "is", "a", "process", "of", "management", "over", "time", "and", "involves", "several", "factors", "."], "h": {"id": "C0085417", "name": "C0085417#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4281785", "name": "C4281785#ent", "pos": [7, 8]}}
{"token": ["The", "most", "important", "of", "all", "was", "tonic", "seizure", "of", "C0085417#ent", "<e1>", "in", "the", "face", "which", "was", "not", "seen", "in", "the", "C4281785#ent", "<e2>"], "h": {"id": "C0085417", "name": "C0085417#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4281785", "name": "C4281785#ent", "pos": [20, 21]}}
{"token": ["Perfusion", "of", "the", "isolated", "brain", "with", "the", "C0242975#ent", "<e1>", "picrotoxin", ",", "however", ",", "could", "induce", "C0014556#ent", "<e2>"], "h": {"id": "C0242975", "name": "C0242975#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [15, 16]}}
{"token": ["The", "reliability", "of", "conduction", "decreased", "by", "the", "application", "of", "cadmium", ",", "a", "C3536851#ent", "<e1>", "4-amino", "pyridine", "a", "fast", "potassium", "channel", "blocker", "or", "apamin", "or", "muscarine", ",", "the", "C3494348#ent", "<e2>", "of", "calcium-dependent", "potassium", "channels"], "h": {"id": "C3536851", "name": "C3536851#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [27, 28]}}
{"token": ["The", "novel", "serine-threonine", "kinase", "C0812228#ent", "<e1>", "is", "a", "critical", "C0014442#ent", "<e2>", "in", "cell", "survival"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["We", "investigated", "the", "efficacy", "of", "using", "the", "C0017837#ent", "<e1>", "GST", ")", "activity", "of", "blood", "lymphocytes", "C1743883#ent", "<e2>", "expression", "as", "biomarkers", "of", "risk", "for", "colorectal", "cancer"], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1743883", "name": "C1743883#ent", "pos": [15, 16]}}
{"token": ["C0017837#ent", "<e1>", "1", ",", "an", "avian", "C1743883#ent", "<e2>", "enzyme", "with", "high", "sequence", "with", "rGSTM3-3", "was", "expressed", "heterologously", "in", "Escherichia", "coli"], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1743883", "name": "C1743883#ent", "pos": [6, 7]}}
{"token": ["production", "by", "2-fold", ",", "and", "this", "was", "prevented", "by", "C0287041#ent", "<e1>", "and", "by", "C0108578#ent", "<e2>", ",", "suggesting", "a", "critical", "role", "of", "AT1", "receptor", "H(2)O(2", ")", "in", "this", "response", "(", ".", ")"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0108578", "name": "C0108578#ent", "pos": [13, 14]}}
{"token": ["Since", "sucrose", "is", "not", "an", "inducer", "of", "the", "permease", ",", "expression", "of", "the", "C1412290#ent", "<e1>", "must", "be", "C0907533#ent", "<e2>", "in", "order", "to", "allow", "growth", "of", "the", "hxt-null", "strain", "on", "sucrose", "."], "h": {"id": "C1412290", "name": "C1412290#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [17, 18]}}
{"token": ["High", "level", "of", "suspicion", "of", "development", "B.", "fragilis", "C0003869#ent", "<e1>", "be", "present", "in", "patients", "with", "C0022408#ent", "<e2>", "whom", "gastrointestinal", "or", "skin", "surgery", "previously", "performed", "."], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "the", "emerging", "evidence", "for", "the", "role", "of", "C1366449#ent", "<e1>", "in", "various", "C0033581#ent", "<e2>", "as", "yet", "unexplored", "therapeutic", "potentials", "PAR1", "antagonists", "in", "various", "C0033581#ent", "<e2>"], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [14, 15]}}
{"token": ["Previous", "studies", "showed", "that", "PTEN", "is", "a", "C0031686#ent", "<e1>", "a", "substrate", "of", "C3490418#ent", "<e2>", "CK2", ")", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3490418", "name": "C3490418#ent", "pos": [12, 13]}}
{"token": ["This", "study", "was", "designed", "to", "test", "the", "hypothesis", "that", "C0886658#ent", "<e1>", "inhibits", "sensory", "nerve", "to", "reduce", "flare", "and", "C1422257#ent", "<e2>", "in", "human", "skin", "."], "h": {"id": "C0886658", "name": "C0886658#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422257", "name": "C1422257#ent", "pos": [18, 19]}}
{"token": ["C0136134#ent", "<e1>", ",", "a", "component", "of", "the", "extracellular", "matrix", "C3889469#ent", "<e2>", ")", ",", "is", "essential", "for", "myofilament", "formation", "and", "muscle", "attachment", "in", "Caenorhabditis", "elegans"], "h": {"id": "C0136134", "name": "C0136134#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889469", "name": "C3889469#ent", "pos": [9, 10]}}
{"token": ["These", "experiments", "were", "carried", "out", "by", "determining", "the", "changes", "in", "electrophoretic", "mobility", "EAT", "cells", "treatment", "with", "several", "highly", "purified", "C0597094#ent", "<e1>", ",", "neuraminidase", ",", "and", "C1615665#ent", "<e2>", "."], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1615665", "name": "C1615665#ent", "pos": [25, 26]}}
{"token": ["Chimeric", "recombinant", "proteins", "human", "C1539104#ent", "<e1>", "and", "mouse", "C1416871#ent", "<e2>", "were", "used", "to", "determine", "the", "location", "of", "the", "epitopes", "for", "these", "mAbs", "."], "h": {"id": "C1539104", "name": "C1539104#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416871", "name": "C1416871#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "the", "level", "of", "C1334468#ent", "<e1>", "mRNA", "in", "C0156221#ent", "<e2>", "not", "differ", "significantly", "from", "that", "in", "control", "glomeruli", "."], "h": {"id": "C1334468", "name": "C1334468#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [10, 11]}}
{"token": ["Thus", "C0019593#ent", "<e1>", "atenolol", "was", "the", "most", "effective", "means", "of", "reducing", "C0010054#ent", "<e2>", "during", "exercise", "and", "at", "rest", "at", "night", "without", "causing", "deterioration", "in", "any", "patient", "."], "h": {"id": "C0019593", "name": "C0019593#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [11, 12]}}
{"token": ["We", "examined", "the", "effect", "of", "a", "C0019593#ent", "<e1>", "haemodynamic", "and", "ischaemic", "responses", "exercise", "in", "patients", "with", "C0010054#ent", "<e2>"], "h": {"id": "C0019593", "name": "C0019593#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "whether", "an", "C0019593#ent", "<e1>", "attenuates", "the", "PMN-mediated", "contractile", "dysfunction", "C0010054#ent", "<e2>"], "h": {"id": "C0019593", "name": "C0019593#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [17, 18]}}
{"token": ["These", "data", "indicate", "that", "GIP", "receptor", "antagonism", "using", "(", "C1313414#ent", "<e1>", "provides", "an", "effective", "means", "of", "countering", "obesity", "and", "related", "C0011847#ent", "<e2>", "induced", "by", "consumption", "of", "a", "high-fat", ",", "energy-rich", "diet", "."], "h": {"id": "C1313414", "name": "C1313414#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [20, 21]}}
{"token": ["This", "study", "examined", "the", "ability", "of", "(", "C1313414#ent", "<e1>", "to", "counter", "the", "development", "of", "obesity", ",", "insulin", "resistance", "C0011847#ent", "<e2>", "in", "mice", "fed", "high-fat", "and", "cafeteria", "diets", "."], "h": {"id": "C1313414", "name": "C1313414#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [18, 19]}}
{"token": ["In", "the", "presence", "of", "ganglion", "non-neuronal", "cells", "PCM", "treatment", "increased", "choline", "acetyltransferase", "C0393576#ent", "<e1>", ")", "and", "decreased", "tyrosine", "hydroxylase", "C0001962#ent", "<e2>", ")", "and", "somatostatin", "(", "SO", ")", "."], "h": {"id": "C0393576", "name": "C0393576#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "the", "C0694897#ent", "<e1>", "not", "detected", "in", "any", "rat", "C2699120#ent", "<e2>", "(", "0/8", ")", "."], "h": {"id": "C0694897", "name": "C0694897#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2699120", "name": "C2699120#ent", "pos": [10, 11]}}
{"token": ["C0064833#ent", "<e1>", "PMN", ")", "dysfunction", "has", "been", "reported", "in", "C3854222#ent", "<e2>", "patients", "."], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [9, 10]}}
{"token": ["Recently", ",", "the", "molecular", "basis", "IV", "was", "ascribed", "to", "loss-of-function", "mutations", "in", "the", "C0017337#ent", "<e1>", "encoding", "filaggrin", "(", "C1414633#ent", "<e2>", ")", ",", "namely", "p", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414633", "name": "C1414633#ent", "pos": [18, 19]}}
{"token": ["Loss-of-function", "variants", "in", "the", "C0017337#ent", "<e1>", "encoding", "filaggrin", "(", "C1414633#ent", "<e2>", ")", "are", "major", "determinants", "of", "eczema", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414633", "name": "C1414633#ent", "pos": [9, 10]}}
{"token": ["Currently", ",", "most", "interest", "is", "addressed", "to", "trans", "fatty", "acids", "C1705607#ent", "<e1>", ")", "and", "particularly", "C1257880#ent", "<e2>", "CLA", ")", "with", "BMF", "being", "the", "main", "source", "of", "CLA", "in", "food", "."], "h": {"id": "C1705607", "name": "C1705607#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1257880", "name": "C1257880#ent", "pos": [15, 16]}}
{"token": ["NotchIC", ",", "together", "with", "the", "C1424132#ent", "<e1>", "form", "a", "ternary", "complex", "CSL", "that", "activates", "transcription", "from", "C1417679#ent", "<e2>", "that", "are", "responsive", "to", "Notch", "signaling"], "h": {"id": "C1424132", "name": "C1424132#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "we", "have", "demonstrated", "that", "this", "C1413947#ent", "<e1>", "and", "SOS-controlled", "gene", "encodes", "a", "novel", "C0012892#ent", "<e2>", "DNA", "Pol", "IV", "which", "is", "able", "to", "dramatically", "increase", "the", "untargeted", "mutagenesis", "of", "F'", "plasmid"], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [15, 16]}}
{"token": ["To", "evaluate", "whether", "hemodynamic", "tolerance", "to", "nicorandil", ",", "a", "nitrate", "and", "potassium", "channel", "opener", "14", "patients", "with", "C0018802#ent", "<e1>", "CHF", ")", "were", "treated", "with", "nicorandil", "and", "11", "were", "treated", "with", "C0017887#ent", "<e2>", "(", "GTN", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [30, 31]}}
{"token": ["We", "investigated", "the", "C1710463#ent", "<e1>", "mechanism", "of", "FLRG", "expression", "in", "HepG2", "cells", "treatment", "with", "C1366557#ent", "<e2>", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366557", "name": "C1366557#ent", "pos": [14, 15]}}
{"token": ["The", "pharmacokinetics", "of", "C0216784#ent", "<e1>", "are", "predictable", "in", "C0018801#ent", "<e2>", "patients", "within", "the", "dose", "range", "of", "40", "-", "160", "mg", "BID", "."], "h": {"id": "C0216784", "name": "C0216784#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [8, 9]}}
{"token": ["Products", "containing", "terbutaline", ",", "formoterol", ",", "C0054201#ent", "<e1>", ",", "and", "the", "combination", "C1276807#ent", "<e2>", "are", "widely", "used", "by", "patients", "with", "asthma", "and", "COPD", "."], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [6, 7]}, "relation": "part_of", "t": {"id": "C1276807", "name": "C1276807#ent", "pos": [12, 13]}}
{"token": ["Studies", "have", "also", "shown", "that", "the", "beneficial", "safety", "profiles", "and", "dose", "relationships", "of", "both", "C0054201#ent", "<e1>", "and", "formoterol", "allow", "dose", "adjustments", "C1276807#ent", "<e2>", "in", "response", "to", "variations", "in", "the", "patient's", "asthma", "."], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [14, 15]}, "relation": "part_of", "t": {"id": "C1276807", "name": "C1276807#ent", "pos": [21, 22]}}
{"token": ["17alpha-E(2", ")", ",", "a", "weak", "estrogen", "exhibited", "both", "agonistic", "and", "antagonistic", "effects", "and", "caused", "a", "time-", "and", "dose-dependent", "induction", "of", "C1823619#ent", "<e1>", "mRNA", "expression", "in", "C1704975#ent", "<e2>", "rat", "pituitary", "tumor", "cells"], "h": {"id": "C1823619", "name": "C1823619#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1704975", "name": "C1704975#ent", "pos": [25, 26]}}
{"token": ["There", "is", "now", "evidence", "to", "suggest", "that", "C0376571#ent", "<e1>", "and", "BRCA2", "are", "involved", "in", "the", "response", "of", "cells", "DNA", "damage", "C1141648#ent", "<e2>"], "h": {"id": "C0376571", "name": "C0376571#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1141648", "name": "C1141648#ent", "pos": [20, 21]}}
{"token": ["Previous", "studies", "from", "our", "laboratory", "and", "others", "have", "shown", "the", "C0003392#ent", "<e1>", "and", "proapoptotic", "effects", "of", "3,3'-diindolylmethane", "(", "C0114346#ent", "<e2>", ")", "in", "prostate", "cancer", "cells", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0114346", "name": "C0114346#ent", "pos": [18, 19]}}
{"token": ["of", "ticlopidine", "or", "C0070166#ent", "<e1>", "from", "the", "first", "day", "of", "C0011849#ent", "<e2>", "."], "h": {"id": "C0070166", "name": "C0070166#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}}
{"token": ["Their", "C1413505#ent", "<e1>", "and", "lipase", "secretion", "were", "measured", "by", "titrimetric", "methods", "and", "C1100642#ent", "<e2>", "A(1", ")", "by", "phosphorus", "magnetic", "resonance", "spectroscopy", "(31)P", "NMR", ")", "."], "h": {"id": "C1413505", "name": "C1413505#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1100642", "name": "C1100642#ent", "pos": [12, 13]}}
{"token": ["However", ",", "in", "the", "three", "20-min", "stimulation", "periods", "of", "the", "pancreatic", "function", "test", "pancreatic", "phospholipase", "cosecreted", "with", "lipase", "and", "C1413505#ent", "<e1>", ",", "and", "average", "C1413505#ent", "<e1>", "and", "C1100642#ent", "<e1>", "secretion", "rates", "follow", "a", "similar", "or", "parallel", "pattern"], "h": {"id": "C1413505", "name": "C1413505#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1100642", "name": "C1100642#ent", "pos": [27, 28]}}
{"token": ["HLA", "data", "support", "the", "hypothesis", "that", "C0011854#ent", "<e1>", "is", "a", "C0019247#ent", "<e2>"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [10, 11]}}
{"token": ["These", "data", "support", "the", "hypothesis", "that", "C0011854#ent", "<e1>", "is", "a", "C0019247#ent", "<e2>"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [10, 11]}}
{"token": ["Accordingly", ",", "progression", "to", "C0011854#ent", "<e1>", "requires", "the", "unfortunate", "combination", "of", "C0019247#ent", "<e2>", "susceptibility", ",", "a", "diabetogenic", "trigger", ",", "and", "a", "high", "exposure", "to", "a", "driving", "antigen"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [11, 12]}}
{"token": ["The", "tg", "alpha", "for", "C0055661#ent", "<e1>", ",", "tectochrysin", "and", "C0060992#ent", "<e2>", "were", "all", "under", "0.180", "."], "h": {"id": "C0055661", "name": "C0055661#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060992", "name": "C0060992#ent", "pos": [9, 10]}}
{"token": ["This", "report", "describes", "a", "patient", "who", "developed", "cyclophosphamide", "associated", "cystitis", "and", "C0032310#ent", "<e1>", "while", "being", "treated", "for", "C3495801#ent", "<e2>"], "h": {"id": "C0032310", "name": "C0032310#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3495801", "name": "C3495801#ent", "pos": [17, 18]}}
{"token": ["A", "monoclonal", "antibody", "with", "the", "C0017351#ent", "<e1>", "TEC", "IgM", ")", "has", "been", "conjugated", "to", "saporin-6", "(", "C2699241#ent", "<e2>", ")", ",", "which", "is", "the", "major", "ribosome-inactivating", "protein", "the", "seeds", "of", "the", "plant", "Saponaria", "officinalis"], "h": {"id": "C0017351", "name": "C0017351#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2699241", "name": "C2699241#ent", "pos": [16, 17]}}
{"token": ["The", "presence", "of", "generalized", "cytoskeletal", "abnormalities", "including", "few", "microtubules", "and", "accumulated", "intermediate", "filaments", "IFs", ")", ",", "in", "C3810578#ent", "<e1>", "suggests", "an", "essential", "role", "of", "C1414964#ent", "<e2>", "in", "cytoskeletal", "organization", "dynamics", "."], "h": {"id": "C3810578", "name": "C3810578#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414964", "name": "C1414964#ent", "pos": [24, 25]}}
{"token": ["These", "data", "support", "the", "hypothesis", "that", "C1417708#ent", "<e1>", "inhibition", "prevents", "early", "C0236970#ent", "<e2>", "in", "the", "presence", "of", "oxidative", "stress"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0236970", "name": "C0236970#ent", "pos": [11, 12]}}
{"token": ["From", "12", "months", "of", "age", "on", ",", "MMTV-neu", "mice", "lacking", "C1706113#ent", "<e1>", "also", "experience", "body", "weight", "loss", "atrophy", "of", "the", "mammary", "fat", "pad", "C0853662#ent", "<e2>", "reduced", "survival", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0853662", "name": "C0853662#ent", "pos": [23, 24]}}
{"token": ["Elastic", "fibers", "progressively", "lysed", "during", "maturation", "and", "aging", "and", "in", "an", "accelerated", "fashion", "in", "several", "C0042251#ent", "<e1>", "as", "diabetes", ",", "C0003850#ent", "<e2>", ",", "emphysema", "and", "several", "skin", "diseases"], "h": {"id": "C0042251", "name": "C0042251#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [20, 21]}}
{"token": ["The", "practical", "value", "renin", "secretion", "studies", "in", "hypertension", "associated", "with", "C0022658#ent", "<e1>", "other", "than", "C0035067#ent", "<e2>", "has", "not", "been", "documented", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0035067", "name": "C0035067#ent", "pos": [14, 15]}}
{"token": ["Overactivity", "of", "the", "renal", "RAS", "been", "associated", "with", "C0022658#ent", "<e1>", "including", "nephropathies", "and", "C0035067#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0035067", "name": "C0035067#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "whether", "ONO-1078", "[", "pranlukast", ",", "4-oxo-8-[p-(4-phenylbutyloxy)benzoyl-amono]-2-(tetrazol-5-yl)-4H-1-benzopyran", "hemihydrate", "]", ",", "a", "potent", "C3537183#ent", "<e1>", "possesses", "a", "neuroprotective", "effect", "C0007785#ent", "<e2>", "rats", ",", "and", "to", "explore", "its", "possible", "mechanism", "of", "action", "."], "h": {"id": "C3537183", "name": "C3537183#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [19, 20]}}
{"token": ["The", "C0010762#ent", "<e1>", "the", "first", "member", "of", "a", "new", "family", ",", "C3899480#ent", "<e2>", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3899480", "name": "C3899480#ent", "pos": [11, 12]}}
{"token": ["Cytochrome", "P450", "C0010762#ent", "<e1>", ")", "enzymes", "belonging", "to", "the", "C3899480#ent", "<e2>", "highly", "inducible", "by", "polycyclic", "aromatic", "hydrocarbons", "other", "environmental", "chemicals", "play", "a", "major", "role", "in", "the", "metabolism", "of", "many", "foreign", "chemicals", "endogenous", "substances", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3899480", "name": "C3899480#ent", "pos": [9, 10]}}
{"token": ["Functional", "analysis", "the", "C3275256#ent", "<e1>", "promoter", "demonstrates", "that", "C1414316#ent", "<e2>", "Egr-1", ")", "is", "an", "important", "transcriptional", "regulator", "C3275256#ent", "<e1>", "."], "h": {"id": "C3275256", "name": "C3275256#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414316", "name": "C1414316#ent", "pos": [8, 9]}}
{"token": ["There", "were", "six", "patients", "with", "native", "C0340359#ent", "<e1>", "five", "cases", "of", "C4288846#ent", "<e2>", "the", "HIE", "group", "."], "h": {"id": "C0340359", "name": "C0340359#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C4288846", "name": "C4288846#ent", "pos": [11, 12]}}
{"token": ["Forty-eight", "cases", "of", "host", "C0340359#ent", "<e1>", "24", "cases", "of", "C4288846#ent", "<e2>", "during", "a", "concurrent", "period", "of", "time", "were", "analyzed", "to", "assess", "differences", "between", "the", "two", "groups", "."], "h": {"id": "C0340359", "name": "C0340359#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C4288846", "name": "C4288846#ent", "pos": [9, 10]}}
{"token": ["The", "human", "C0105421#ent", "<e1>", "a", "protein", "with", "serine/threonine", "kinase", "activity", "regulatory", "domains", "the", "small", "G-proteins", "RAC", "and", "C0082645#ent", "<e2>", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [17, 18]}}
{"token": ["Although", "we", "were", "able", "to", "demonstrate", "that", "C0105421#ent", "<e1>", "can", "function", "as", "an", "exchange", "factor", "C0082645#ent", "<e2>", "in", "vivo", "NF-kappaB", "activation", "to", "occur", "via", "a", "Cdc42-independent", "mechanism", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [15, 16]}}
{"token": ["The", "PI", ",", "PIL", ",", "and", "C1412050#ent", "<e1>", "loci", "have", "been", "localized", "to", "14q32.1", ",", "the", "C1452313#ent", "<e2>", "locus", "has", "been", "localized", "to", "14q31-14q32.1", "and", "PCI", "has", "been", "mapped", "to", "chromosome", "14"], "h": {"id": "C1412050", "name": "C1412050#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1452313", "name": "C1452313#ent", "pos": [16, 17]}}
{"token": ["Randomized", ",", "double-blind", "studies", "both", "valacyclovir", "and", "C0209227#ent", "<e1>", "as", "single-day", "episodic", "therapy", "for", "C0019348#ent", "<e2>", "have", "been", "reported", "in", "the", "literature", "."], "h": {"id": "C0209227", "name": "C0209227#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [14, 15]}}
{"token": ["C0209227#ent", "<e1>", "is", "effective", "in", "the", "suppression", "and", "treatment", "of", "C0019348#ent", "<e2>", "however", ",", "no", "studies", "have", "examined", "the", "optimum", "dosing", "regimen", "for", "HSV", "prophylaxis", "in", "laser", "resurfacing", "."], "h": {"id": "C0209227", "name": "C0209227#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [10, 11]}}
{"token": ["In", "patients", "with", "C1956346#ent", "<e1>", "amiodarone", "and", "C0026289#ent", "<e2>", "are", "similar", "in", "efficacy", "in", "the", "treatment", "of", "VT", "as", "assessed", "by", "electropharmacologic", "testing", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026289", "name": "C0026289#ent", "pos": [7, 8]}}
{"token": ["Akt", "stimulation", "by", "EGF", "and", "TGF-alpha", ",", "but", "not", "by", "C0919506#ent", "<e1>", "was", "almost", "completely", "blocked", "in", "the", "presence", "of", "C0242957#ent", "<e2>", "."], "h": {"id": "C0919506", "name": "C0919506#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [20, 21]}}
{"token": ["A", "review", "is", "presented", "of", "the", "major", "clinical", "features", "of", "a", "number", "of", "glycolipidoses", "including", "Fabry", ",", "C0017205#ent", "<e1>", ",", "Tay-Sachs", ",", "metachromatic", "leukodystrophy", "well", "as", "CeroidLipofucinosis", "and", "C1527336#ent", "<e2>"], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [28, 29]}}
{"token": ["c", ")", "MAb-MC", "inhibited", "C1705794#ent", "<e1>", "and", "ECDE", "in", "the", "two", "dedifferentiated", "lines", "HF1", "and", "C3538895#ent", "<e2>", "by", "50", "-", "80", "%", "."], "h": {"id": "C1705794", "name": "C1705794#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538895", "name": "C3538895#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "we", "have", "determined", "the", "three-dimensional", "structure", "the", "regulatory", "domain", "C1428428#ent", "<e1>", ",", "which", "consists", "of", "two", "cyclic", "nucleotide", "monophosphate", "domains", "and", "one", "C0057472#ent", "<e2>", "(", "Dishevelled", ",", "Egl", ",", "Pleckstrin)", "domain"], "h": {"id": "C1428428", "name": "C1428428#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0057472", "name": "C0057472#ent", "pos": [24, 25]}}
{"token": ["C0068334#ent", "<e1>", "is", "rapidly", "C0025517#ent", "<e2>", "to", "an", "active", "metabolite", "6-methoxy-2-naphthylacetic", "acid", "BRL", "10720", ")", "."], "h": {"id": "C0068334", "name": "C0068334#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}}
{"token": ["To", "observe", "the", "effect", "of", "coptis", "root", "extract", "C1511573#ent", "<e1>", ")", "on", "the", "gene", "expressions", "C0136120#ent", "<e2>", "and", "peroxisome", "proliferator", "activated", "receptor", "gamma", "PPAR-gamma", ")", "in", "atherosclerotic", "plaque", "ApoE-gene", "knockout", "mice", "exploring", "its", "plaque", "stabilizing", "action", "and", "possible", "mechanism", "."], "h": {"id": "C1511573", "name": "C1511573#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0136120", "name": "C0136120#ent", "pos": [15, 16]}}
{"token": ["This", "study", "aimed", "to", "compare", "the", "effects", "of", "C0054836#ent", "<e1>", "with", "ramipril", "and", "losartan", "in", "patients", "with", "C0156221#ent", "<e2>"], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "C1414349#ent", "<e1>", ",", "but", "not", "the", "highly", "related", "eIF4A1", "or", "C3273428#ent", "<e2>", ",", "preferentially", "associates", "with", "spliced", "mRNA", "."], "h": {"id": "C1414349", "name": "C1414349#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273428", "name": "C3273428#ent", "pos": [12, 13]}}
{"token": ["E2", "facilitates", "markedly", "enhanced", "function", "of", "the", "C0043655#ent", "<e1>", "PDK", ")", "and", "C1418818#ent", "<e2>", "PDP", ")", "."], "h": {"id": "C0043655", "name": "C0043655#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418818", "name": "C1418818#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "in", "neuroendocrine", "cells", "C1412687#ent", "<e1>", "guides", "the", "C3811804#ent", "<e2>", "through", "the", "secretory", "pathway", "thereby", "regulating", "the", "V-ATPase-mediated", "process", "of", "Ca(2+)-dependent", "peptide", "secretion", "."], "h": {"id": "C1412687", "name": "C1412687#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811804", "name": "C3811804#ent", "pos": [10, 11]}}
{"token": ["The", "new", "C0107994#ent", "<e1>", "given", "orally", "in", "a", "single", "dose", "300", "micrograms", "to", "15", "C0020514#ent", "<e2>", "patients", "(", "including", "4", "acromegalic", "patients", ",", "2", "of", "whom", "were", "dopamine", "responsive", ")", "."], "h": {"id": "C0107994", "name": "C0107994#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [14, 15]}}
{"token": ["Application", "of", "C1719788#ent", "<e1>", "shows", "an", "average", "33", "%", "improvement", "over", "C0220663#ent", "<e2>", "."], "h": {"id": "C1719788", "name": "C1719788#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220663", "name": "C0220663#ent", "pos": [11, 12]}}
{"token": ["A", "TaqI", "RFLP", "was", "detected", "within", "the", "C1413453#ent", "<e1>", "which", "lies", "between", "the", "loci", "for", "C0342684#ent", "<e2>", "and", "MLS", "."], "h": {"id": "C1413453", "name": "C1413453#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342684", "name": "C0342684#ent", "pos": [15, 16]}}
{"token": ["This", "C0030946#ent", "<e1>", "is", "homologous", "(", "77.9", "%", "identical", ")", "to", "human", "C1415700#ent", "<e2>"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415700", "name": "C1415700#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "the", "anaesthetic", "management", "epidural", "anaesthesia", "a", "patient", "with", "C1839259#ent", "<e1>", "a", "rare", "lower", "motor", "neuron", "disease", "by", "progressive", "C0427055#ent", "<e2>", "and", "wasting", "of", "limbs", "and", "bulbar", "muscles"], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [20, 21]}}
{"token": ["Although", "beta-catenin", "mutations", "not", "alter", "C1705323#ent", "<e1>", "expression", "or", "MAPK", "activity", "mutations", "in", "either", "K-ras", "or", "C1332803#ent", "<e2>", "significantly", "increased", "cyclin", "D1", "expression", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [16, 17]}}
{"token": ["We", "also", "assessed", "whether", "C1705323#ent", "<e1>", "expression", ",", "mutation", "status", "adenomatous", "polyposis", "coli", "APC", ")", ",", "C1332803#ent", "<e2>", ",", "p53", ",", "or", "DNA", "mismatch", "repair", "MMR", ")", "genes", "in", "CRC", "lines", "influenced", "aspirin-induced", "effects", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [16, 17]}}
{"token": ["Genetic", "mutations", "human", "colonic", "cancers", "result", "in", "expression", "of", "cycloxygenase-2", "(", "C1705323#ent", "<e1>", ")", ",", "loss", "of", "membranous", "expression", "of", "C1332803#ent", "<e2>", "and", "E-cadherin", ",", "and", "accumulation", "of", "p53", "protein", "the", "neoplastic", "cells"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [20, 21]}}
{"token": ["In", "rat", ",", "mouse", "and", "cat", "C0030304#ent", "<e1>", ",", "C1415831#ent", "<e2>", "(", "1", "-", "37", ")", "and", "C1415831#ent", "<e2>", "(", "19", "-", "37", ")", "were", "identified", "with", "the", "latter", "being", "the", "major", "molecular", "form"], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415831", "name": "C1415831#ent", "pos": [9, 10]}}
{"token": ["Digestion", "of", "C3889469#ent", "<e1>", "with", "hyaluronidase", "from", "bovine", "testis", "releases", "C1422337#ent", "<e2>", "from", "the", "C3889469#ent", "<e1>", ",", "suggesting", "that", "glycosaminoglycans", "are", "involved", "in", "the", "deposition", "of", "C1422337#ent", "<e2>", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422337", "name": "C1422337#ent", "pos": [10, 11]}}
{"token": ["In", "NIH3T3", "cells", "cotransfected", "with", "C1423874#ent", "<e1>", "and", "GSG1", ",", "both", "proteins", "colocalize", "in", "the", "C1414461#ent", "<e2>", "."], "h": {"id": "C1423874", "name": "C1423874#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [15, 16]}}
{"token": ["Forty-two", "patients", "with", "definite", "or", "C0038013#ent", "<e1>", "included", "in", "a", "6-week", "double-blind", "study", "compare", "sulindac", "with", "C0021246#ent", "<e2>", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [16, 17]}}
{"token": ["Seventeen", "of", "eighteen", "patients", "hospitalized", "for", "C0038013#ent", "<e1>", "a", "three-day", "randomized", ",", "double-blind", "comparison", "of", "100", "mg", "C0021246#ent", "<e2>", ",", "100", "mg", "C0021246#ent", "<e2>", "with", "10", "mg", "diazepam", "and", "matching", "placebo", "as", "night", "medication"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [17, 18]}}
{"token": ["The", "GST", "enzyme", "family", "includes", "the", "cytosolic", "isoforms", "C0769262#ent", "<e1>", ",", "mu", "(", "GSTM", ")", ",", "pi", "(", "C0919451#ent", "<e2>", ")", ",", "theta", "(", "GSTT", ")", "and", "sigma", "(", "GSTS", ")", "."], "h": {"id": "C0769262", "name": "C0769262#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0919451", "name": "C0919451#ent", "pos": [18, 19]}}
{"token": ["This", "study", "provides", "evidence", "for", "an", "enhanced", "inflammatory", "response", "C0011882#ent", "<e1>", "to", "IR", "injury", "via", "C1417708#ent", "<e2>"], "h": {"id": "C0011882", "name": "C0011882#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [15, 16]}}
{"token": ["The", "C3273857#ent", "<e1>", "human", "chromosome", "21", "encodes", "a", "C0033640#ent", "<e2>", "to", "be", "involved", "in", "the", "pathogenesis", "of", "mental", "retardation", "Down's", "syndrome"], "h": {"id": "C3273857", "name": "C3273857#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [8, 9]}}
{"token": ["Neurological", "sequela", "C2063079#ent", "<e1>", "encephalopathy", ",", "myelopathy", "and", "C0031117#ent", "<e2>"], "h": {"id": "C2063079", "name": "C2063079#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [8, 9]}}
{"token": ["C0163401#ent", "<e1>", "protein", "thiols", "lipid", "hydroperoxides", "lipid", "profile", "creatinine", "and", "C1412332#ent", "<e2>", "levels", "were", "estimated", "by", "spectrophotometric", "methods", "CRF", "patients", "on", "conservative", "management", "those", "on", "hemodialysis", "and", "in", "healthy", "controls"], "h": {"id": "C0163401", "name": "C0163401#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [10, 11]}}
{"token": ["C0082731#ent", "<e1>", "be", "reactivated", "by", "both", "exogenous", "and", "endogenous", "C2744579#ent", "<e2>", "."], "h": {"id": "C0082731", "name": "C0082731#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [9, 10]}}
{"token": ["Unlike", "SP-As", "from", "other", "mammalian", "species", ",", "human", "C1420002#ent", "<e1>", "consists", "of", "two", "functional", "gene", "products", "SP-A1", "and", "C1420003#ent", "<e2>", "."], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420003", "name": "C1420003#ent", "pos": [18, 19]}}
{"token": ["Kinetic", "studies", "antigen", "expression", "by", "Western", "blotting", "that", "C3889271#ent", "<e1>", "induced", "as", "early", "as", "6", "h", "after", "C0078956#ent", "<e2>", "treatment", "."], "h": {"id": "C3889271", "name": "C3889271#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [17, 18]}}
{"token": ["However", ",", "little", "is", "known", "about", "how", "C3889271#ent", "<e1>", "expression", "is", "triggered", "initially", "at", "the", "earliest", "stages", "after", "C0078956#ent", "<e2>", "induction", "when", "the", "C/EBP", "alpha", "levels", "are", "still", "limited", "."], "h": {"id": "C3889271", "name": "C3889271#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [18, 19]}}
{"token": ["The", "increased", "pulmonary", "vascular", "resistance", "associated", "with", "adult", "respiratory", "distress", "syndrome", "C0035222#ent", "<e1>", ")", "of", "this", "disease", "was", "shown", "to", "correlate", "inversely", "with", "pulmonary", "wedge", "pressure", "thereby", "excluding", "C1959583#ent", "<e2>", "pulmonary", "edema", "mechanisms", "for", "the", "production", "of", "the", "C0035222#ent", "<e1>", "."], "h": {"id": "C1959583", "name": "C1959583#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [11, 12]}}
{"token": ["The", "biosynthesis", "of", "C3540778#ent", "<e1>", "and", "mineralocorticoids", "requires", "isozymes", "of", "C1413856#ent", "<e2>", "."], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413856", "name": "C1413856#ent", "pos": [10, 11]}}
{"token": ["The", "C0062964#ent", "<e1>", "treatment", "caused", "the", "generation", "of", "reactive", "oxygen", "species", "C0812281#ent", "<e2>", ")", ",", "and", "the", "cell", "cycle", "arrest", "by", "C0062964#ent", "<e1>", "was", "partially", "but", "significantly", "attenuated", "in", "the", "presence", "of", "antioxidant", "N-acetylcysteine", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0062964", "name": "C0062964#ent", "pos": [1, 2]}}
{"token": ["Gliophilic", "neuronal", "migration", "confirmed", "in", "the", "human", "fetus", ",", "with", "radial", "glial", "fibers", "(", "C1335588#ent", "<e1>", ")", "acting", "as", "obligatory", "corridors", "for", "C1427627#ent", "<e2>", "the", "prospective", "neocortex", "underlying", "intermediate", "zone", "IZ", ")", "."], "h": {"id": "C1335588", "name": "C1335588#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1427627", "name": "C1427627#ent", "pos": [22, 23]}}
{"token": ["It", "was", "concluded", "that", "C1414588#ent", "<e1>", "is", "a", "highly", "successful", "treatment", "for", "C0748720#ent", "<e2>"], "h": {"id": "C1414588", "name": "C1414588#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0748720", "name": "C0748720#ent", "pos": [12, 13]}}
{"token": ["Functional", "endoscopic", "sinus", "surgery", "C1414588#ent", "<e1>", ")", ",", "a", "new", "surgical", "approach", "C0748720#ent", "<e2>", "seems", "to", "have", "promising", "results", "in", "the", "treatment", "of", "chronic", "sinusitis", "compared", "to", "prior", "traditional", "techniques", "."], "h": {"id": "C1414588", "name": "C1414588#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0748720", "name": "C0748720#ent", "pos": [12, 13]}}
{"token": ["Our", "results", "have", "implications", "for", "the", "decline", "of", "C1416808#ent", "<e1>", "after", "weaning", "and", "for", "human", "adult-type", "C0022951#ent", "<e2>", ",", "and", "for", "the", "evolutionary", "history", "of", "C1416808#ent", "<e1>", "."], "h": {"id": "C0022951", "name": "C0022951#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416808", "name": "C1416808#ent", "pos": [8, 9]}}
{"token": ["C0059946#ent", "<e1>", "drug", "transport", "human", "P-glycoprotein", "(", "Pgp", ",", "C1704939#ent", "<e2>", ")", "involves", "a", "coordinated", "communication", "between", "its", "drug-binding", "site", "substrate", "site", "and", "the", "nucleotide", "binding/hydrolysis", "domain", "(", "ATP", "sites", ")", "."], "h": {"id": "C0059946", "name": "C0059946#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [9, 10]}}
{"token": ["Concomitantly", ",", "C1705066#ent", "<e1>", "is", "activated", "in", "the", "spinal", "cord", "transgenic", "C1420306#ent", "<e2>", "mice", "."], "h": {"id": "C1705066", "name": "C1705066#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [11, 12]}}
{"token": ["It", "was", "found", "that", "C1260386#ent", "<e1>", "strongly", "accelerated", "C0025677#ent", "<e2>", "uptake", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [8, 9]}}
{"token": ["In", "isolated", "hepatocytes", "the", "influence", "of", "cellular", "glutathione", "C1260386#ent", "<e1>", ")", "on", "initial", "influx", ",", "net", "uptake", "efflux", "of", "C0025677#ent", "<e2>", "(", "MTX", ")", "was", "determined", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [19, 20]}}
{"token": ["bpV", "inhibition", "of", "C1739021#ent", "<e1>", "in", "cells", "leads", "to", "CDK2", "inactivation", "and", "hypophosphorylation", "C1705628#ent", "<e2>", ",", "resulting", "in", "G1-S", "arrest", "induction", "of", "p53-independent", "apoptosis", "."], "h": {"id": "C1739021", "name": "C1739021#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [13, 14]}}
{"token": ["We", "further", "demonstrate", "that", "the", "ability", "of", "E7", "to", "abrogate", "cell", "cycle", "arrest", "activate", "cdc25A", "transcription", ",", "and", "increase", "C1739021#ent", "<e1>", "requires", "intact", "C1705628#ent", "<e2>", "and", "HDAC-1", "binding", "domains"], "h": {"id": "C1739021", "name": "C1739021#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [23, 24]}}
{"token": ["The", "finding", "of", "AGT1", "and", "Asc-2", "has", "established", "a", "new", "subgroup", "of", "the", "C1420191#ent", "<e1>", "whose", "members", "associate", "not", "with", "C4084711#ent", "<e2>", "or", "rBAT", "but", "with", "other", "unknown", "heavy", "chains"], "h": {"id": "C1420191", "name": "C1420191#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4084711", "name": "C4084711#ent", "pos": [20, 21]}}
{"token": ["The", "constitutively", "active", "mutants", "of", "PKC-alpha", "and", "C3811758#ent", "<e1>", "also", "activated", "C0087140#ent", "<e2>", ",", "c-jun", ",", "and", "cyclin", "E", "promoter", "activity"], "h": {"id": "C3811758", "name": "C3811758#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [11, 12]}}
{"token": ["C0085131#ent", "<e1>", "a", "glycosphingolipid", "(", "GSL", ")", "C0085078#ent", "<e2>", "by", "a", "genetic", "deficiency", "acid", "beta-galactosidase", "beta-gal", ")", ",", "the", "enzyme", "that", "catabolyzes", "GM1", "within", "lysosomes", "."], "h": {"id": "C0085131", "name": "C0085131#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [7, 8]}}
{"token": ["Inherited", "deficiency", "sialidase", "results", "in", "sialidosis", "or", "C0085131#ent", "<e1>", ",", "both", "severe", "metabolic", "disorders", "associated", "with", "C0085078#ent", "<e2>", "oligosaccharides", "and", "glycopeptides", "."], "h": {"id": "C0085131", "name": "C0085131#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [16, 17]}}
{"token": ["Pharmacia", "Corp", "(", "formerly", "GD", "Searle", "&", "Co", ")", "is", "developing", "C0961485#ent", "<e1>", ",", "an", "aldosterone", "receptor", "antagonist", "as", "a", "potential", "treatment", "for", "congestive", "heart", "failure", "C0020538#ent", "<e2>"], "h": {"id": "C0961485", "name": "C0961485#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [26, 27]}}
{"token": ["C0011974#ent", "<e1>", "are", "a", "common", "adverse", "event", "during", "C1136254#ent", "<e2>"], "h": {"id": "C0011974", "name": "C0011974#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [8, 9]}}
{"token": ["However", ",", "RNA", "interfering", "plasmid", "inhibiting", "C3273591#ent", "<e1>", "(", "pTER/hPER1-II", ")", "could", "not", "interfere", "expression", "of", "C1415151#ent", "<e2>", "."], "h": {"id": "C3273591", "name": "C3273591#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415151", "name": "C1415151#ent", "pos": [16, 17]}}
{"token": ["Patients", "with", "C0037769#ent", "<e1>", "hypsarrhythmia", "could", "be", "included", "if", "C0076829#ent", "<e2>", "treatment", "had", "started", "at", "an", "age", "of", "<", "or", "=3", "years", "."], "h": {"id": "C0037769", "name": "C0037769#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [9, 10]}}
{"token": ["Seven", "of", "the", "eight", "C0037769#ent", "<e1>", "cases", "improved", "on", "topiramate", "therapy", ",", "attaining", "C0076829#ent", "<e2>", "monotherapy", "in", "three", "infants", "."], "h": {"id": "C0037769", "name": "C0037769#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [13, 14]}}
{"token": ["Sequence", "analysis", "the", "C1420610#ent", "<e1>", "cDNA", "revealed", "an", "C1412821#ent", "<e2>", "1020", "bp", ",", "potentially", "coding", "for", "a", "protein", "of", "340", "amino", "acids", "aa", ")", "."], "h": {"id": "C1420610", "name": "C1420610#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [8, 9]}}
{"token": ["A", "group", "of", "Huntington", "disease", "HD", ")", "families", "of", "Italian", "ancestry", "analyzed", "for", "11", "RFLPs", "from", "C0678933#ent", "<e1>", "in", "4p16", "and", "C1516876#ent", "<e2>", "linked", "to", "the", "HD", "gene", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [21, 22]}}
{"token": ["Molecular", "and", "phylogenetic", "analyses", "the", "18S", "ribosomal", "RNA", "heat", "shock", "protein", "70", "and", "C0678933#ent", "<e1>", "C.", "suis", "to", "be", "C1516876#ent", "<e2>", "distinct", "from", "all", "known", "species", "and", "genotypes", "of", "Cryptosporidium", ",", "and", "thus", "is", "named", "as", "Cryptosporidium", "suis"], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [19, 20]}}
{"token": ["To", "describe", "C0678933#ent", "<e1>", "differentiate", "blood", "pressures", "two", "C1516876#ent", "<e2>", "hypertensive", "strains", ",", "the", "Dahl", "salt-sensitive", "(", "S", ")", "rat", "and", "the", "Albino", "Surgery", "(", "AS", ")", "rat", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [8, 9]}}
{"token": ["Electrophoretic", "analysis", "on", "2", "to", "4", "C0678933#ent", "<e1>", "that", "two", "or", "more", "trunks", "were", "C1516876#ent", "<e2>", "distinct", "individuals", "in", "twenty", "of", "the", "twenty-five", "multi-trunk", "trees", "sampled", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [14, 15]}}
{"token": ["Calcium", "channel", "blockers", "C0003015#ent", "<e1>", "sartans", ",", "phosphodiesterase-5", "inhibitors", "serotonin", "re-uptake", "blockers", "are", "used", "for", "C0034734#ent", "<e2>", "phenomenon", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034734", "name": "C0034734#ent", "pos": [15, 16]}}
{"token": ["They", "were", "hydroxycinnamic", "acid", "amides", "N-trans-caffeoyl-l-DOPA", "or", "clovamide", ",", "C1435089#ent", "<e1>", "or", "deoxiclovamide", ",", "and", "C1435088#ent", "<e2>", "."], "h": {"id": "C1435089", "name": "C1435089#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1435088", "name": "C1435088#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "some", "C0037207#ent", "<e1>", ",", "especially", "those", "encoding", "membrane-associated", "or", "cytoplasmatic", "proteins", "C0000744#ent", "<e2>", ",", "rel", "or", "mil/raf", ",", "were", "transcribed", "at", "a", "relatively", "constant", "rate", "during", "the", "cell", "cycle"], "h": {"id": "C0037207", "name": "C0037207#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [14, 15]}}
{"token": ["C0062773#ent", "<e1>", "deacetylases", ",", "and", "chromatin-modifying", "proteins", "accumulated", "in", "complexes", "with", "C0023524#ent", "<e2>", "these", "nuclear", "bodies", "the", "evidence", "of", "their", "role", "in", "transcription", "regulation"], "h": {"id": "C0062773", "name": "C0062773#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [11, 12]}}
{"token": ["CREB", "is", "C0669365#ent", "<e1>", "expressed", "in", "C1413014#ent", "<e2>", "and", "is", "downregulated", "after", "stimulation", "with", "dbcAMP", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413014", "name": "C1413014#ent", "pos": [6, 7]}}
{"token": ["C0669365#ent", "<e1>", "mRNA", "for", "5-HT2A", "receptors", "present", "in", "control", "and", "transfected", "C1413014#ent", "<e2>", "glial/5-HT1D", "beta", "cells", ",", "whereas", "mRNA", "for", "5-HT1D", "beta", "receptor", "sites", "only", "present", "in", "the", "transfected", "C1413014#ent", "<e2>", "glial/5-HT1D", "beta", "cell", "line", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413014", "name": "C1413014#ent", "pos": [11, 12]}}
{"token": ["We", "have", "identified", "11", "proteins", "in", "lysates", "of", "human", "A375", "melanoma", "cells", ",", "including", ":", "alpha-enolase", ",", "C1416713#ent", "<e1>", ",", "stathmin", ",", "protein", "disulfide", "isomerase", "tropomyosin", ",", "C0669516#ent", "<e2>", "nucleoside", "diphosphate", "kinase", "A", "galaptin", ",", "and", "triosephosphate", "isomerase"], "h": {"id": "C1416713", "name": "C1416713#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [27, 28]}}
{"token": ["These", "data", "characterize", "C0284219#ent", "<e1>", "a", "clonidine-like", ",", "centrally", "acting", "C0003364#ent", "<e2>"], "h": {"id": "C0284219", "name": "C0284219#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [10, 11]}}
{"token": ["C0284219#ent", "<e1>", ",", "a", "new", "C0003364#ent", "<e2>", "binds", "to", "alpha2-receptors", "in", "animal", "brain", "preparations", "was", "studied", "in", "normal", "healthy", "male", "volunteers", "."], "h": {"id": "C0284219", "name": "C0284219#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [5, 6]}}
{"token": ["perfusion", "of", "C0284219#ent", "<e1>", ",", "a", "new", "C0003364#ent", "<e2>", "clonidine", "decreased", "the", "frequency", "of", "discharge", "of", "LC", "neurons", "."], "h": {"id": "C0284219", "name": "C0284219#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [7, 8]}}
{"token": ["Patients", "with", "bulimia", "nervosa", "BN", ")", "may", "show", "C0040436#ent", "<e1>", "resulting", "from", "the", "effect", "of", "C0232608#ent", "<e2>"], "h": {"id": "C0040436", "name": "C0040436#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0232608", "name": "C0232608#ent", "pos": [15, 16]}}
{"token": ["The", "present", "study", "assessed", "whether", "the", "serum", "concentrations", "of", "tissue", "inhibitor", "C1334706#ent", "<e1>", "TIMP-1", ")", "and", "cytokines", "are", "altered", "in", "patients", "with", "C0302809#ent", "<e2>", "whether", "plasma", "exchange", "these", "concentrations", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0302809", "name": "C0302809#ent", "pos": [22, 23]}}
{"token": ["This", "equilibrium", "would", "be", "controlled", "by", "the", "concentration", "of", "Ca++", ",", "C1705556#ent", "<e1>", ",", "and", "various", "C1332770#ent", "<e2>"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332770", "name": "C1332770#ent", "pos": [16, 17]}}
{"token": ["C0289946#ent", "<e1>", "is", "a", "novel", "dopamine", "autoreceptor", "C2987634#ent", "<e2>", "and", "partial", "dopamine", "D2/D3", "C2987634#ent", "<e2>", "that", "is", "currently", "under", "development", "for", "the", "treatment", "of", "schizophrenia", "."], "h": {"id": "C0289946", "name": "C0289946#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}}
{"token": ["To", "determine", "if", "alpha", "receptors", "the", "C1706334#ent", "<e1>", "neuron", "are", "required", "for", "the", "action", "of", "C1706141#ent", "<e2>", ",", "the", "tissue", "was", "incubated", "with", "phentolamine", ",", "plus", "C1706141#ent", "<e2>", "."], "h": {"id": "C1706334", "name": "C1706334#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706141", "name": "C1706141#ent", "pos": [15, 16]}}
{"token": ["Ethanol", "completely", "blocked", "the", "release", "of", "C1706334#ent", "<e1>", "induced", "by", "C1706141#ent", "<e2>", "and", "the", "increase", "in", "PGE2", "induced", "by", "C1706141#ent", "<e2>", "."], "h": {"id": "C1706334", "name": "C1706334#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706141", "name": "C1706141#ent", "pos": [10, 11]}}
{"token": ["Ethanol", "acts", "at", "this", "step", ",", "because", "it", "completely", "blocked", "the", "release", "of", "PGE2", ",", "leukotrienes", ",", "and", "C1706334#ent", "<e1>", "induced", "by", "C1706141#ent", "<e2>", "."], "h": {"id": "C1706334", "name": "C1706334#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1706141", "name": "C1706141#ent", "pos": [22, 23]}}
{"token": ["Inhibition", "of", "glial", "and", "C1420120#ent", "<e1>", "DL-threo-beta-benzyloxyaspartate", "(", "TBOA", ")", "enhanced", "the", "group", "I", "slow", "C0566602#ent", "<e2>", "about", "eightfold", "."], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [15, 16]}}
{"token": ["p38", "MAPK", "C1417029#ent", "<e1>", "or", "-activated", "kinase", "(", "PRAK", ";", "MK5", ")", ",", "C1431394#ent", "<e2>", "MK2", ")", ",", "and", "heat", "shock", "protein", "25", "hsp25", ")", "mRNAs", "and", "proteins", "were", "detected", "throughout", "preimplantation", "development", "."], "h": {"id": "C1417029", "name": "C1417029#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1431394", "name": "C1431394#ent", "pos": [13, 14]}}
{"token": ["C1417029#ent", "<e1>", "(", "mitogen-activated", "protein", "kinase", "[MAPK]-activated", "protein", "kinase", "5", ",", "also", "designated", "PRAK", "(", "C1431394#ent", "<e2>", "and", "-activated", "kinase", ")", ",", "was", "deleted", "from", "mice", "by", "homologous", "recombination"], "h": {"id": "C1417029", "name": "C1417029#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1431394", "name": "C1431394#ent", "pos": [15, 16]}}
{"token": ["The", "first", "case", "manifested", "clinically", "with", "C0162671#ent", "<e1>", ",", "the", "second", "case", "manifested", "with", "C0162674#ent", "<e2>", ",", "and", "third", "case", "was", "characterized", "by", "recurrent", "migraine-like", "headache", "tremor", ",", "and", "epilepsy", "."], "h": {"id": "C0162671", "name": "C0162671#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "endocrine", "function", "patients", "with", "mitochondrial", "myopathy", "encephalopathy", ",", "lactic", "acidosis", "stroke-like", "episodes", "C0162671#ent", "<e1>", ")", ",", "myoclonus", "epilepsy", "associated", "with", "ragged-red", "fibers", "MERRF", ")", ",", "and", "C0162674#ent", "<e2>", "CPEO", ")", "."], "h": {"id": "C0162671", "name": "C0162671#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [28, 29]}}
{"token": ["C0751711#ent", "<e1>", "AION", ")", "is", "a", "C1263853#ent", "<e2>", "the", "eye", "seen", "in", "isolation", "or", "as", "a", "manifestation", "of", "underlying", "disease", "."], "h": {"id": "C0751711", "name": "C0751711#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1263853", "name": "C1263853#ent", "pos": [6, 7]}}
{"token": ["The", "influence", "of", "C0016365#ent", "<e1>", "on", "triazolam", "pharmacokinetics", "was", "studied", "because", "of", "changes", "in", "C0012010#ent", "<e2>", "pharmacokinetics", "reportedly", "produced", "by", "C0016365#ent", "<e1>", "."], "h": {"id": "C0016365", "name": "C0016365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [14, 15]}}
{"token": ["These", "algorithms", "were", "applied", "to", "confocal", "images", "of", "C0009325#ent", "<e1>", "with", "reconstituted", "C3282676#ent", "<e2>", "to", "demonstrate", "the", "computation", "of", "orientations", "of", "individual", "fibers", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [8, 9]}, "relation": "structural_class_of", "t": {"id": "C3282676", "name": "C3282676#ent", "pos": [12, 13]}}
{"token": ["A", "series", "of", "structurally", "novel", "benzothiazole", "based", "small", "molecule", "inhibitors", "C0919477#ent", "<e1>", ")", "was", "prepared", "to", "elucidate", "their", "structure-activity", "relationships", "C4283882#ent", "<e2>", ")", ",", "selectivity", "and", "cell", "activity", "the", "T-cell", "proliferation", "assay"], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4283882", "name": "C4283882#ent", "pos": [20, 21]}}
{"token": ["C0068443#ent", "<e1>", "reduced", "the", "severity", "of", "C1299919#ent", "<e2>", "measured", "by", "a", "reduction", "in", "cecal", "lesions", "an", "improvement", "in", "bird", "performance", "."], "h": {"id": "C0068443", "name": "C0068443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1299919", "name": "C1299919#ent", "pos": [6, 7]}}
{"token": ["C0017086#ent", "<e1>", "of", "the", "left", "upper", "limb", "found", "to", "complicate", "severe", "mitral", "stenosis", "with", "C0018802#ent", "<e2>", "a", "sixty-eight-year-old", "woman", "with", "a", "documented", "left", "atrial", "thrombus"], "h": {"id": "C0017086", "name": "C0017086#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}}
{"token": ["Five", "chitin", "synthase", "(", "WdCHS", ")", "C1417679#ent", "<e1>", "have", "been", "identified", "in", "the", "melanized", "human", "pathogen", "Wangiella", "dermatitidis", "C1705344#ent", "<e2>", ",", "WdCHS2", ",", "WdCHS3", ",", "WdCHS4", "and", "WdCHS5", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705344", "name": "C1705344#ent", "pos": [18, 19]}}
{"token": ["A", "new", "method", "of", "treating", "osteo-arthritis", "of", "the", "C1709823#ent", "<e1>", "involving", "an", "intraneural", "injection", "of", "a", "depot", "steroid", ",", "C0077004#ent", "<e2>", "is", "described", "."], "h": {"id": "C1709823", "name": "C1709823#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0077004", "name": "C0077004#ent", "pos": [19, 20]}}
{"token": ["Two", "separate", "families", "of", "NK", "cell", "receptors", "been", "identified", ":", "the", "immunoglobulin-like", "family", "C3540490#ent", "<e1>", ",", "LIR", ")", "and", "C-type", "lectin-like", "family", "Ly49", ",", "C1425775#ent", "<e2>", ",", "and", "CD94/NKG2", ")", "."], "h": {"id": "C3540490", "name": "C3540490#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1425775", "name": "C1425775#ent", "pos": [24, 25]}}
{"token": ["C0247025#ent", "<e1>", "significantly", "inhibited", "C1420002#ent", "<e2>", ",", "fib", "(", "2", ",", "4", ",", "8", "g/L", ")", ",", "ADP", ",", "ADP", "+", "fib", "combination", ",", "and", "5HT-induced", "aggregation", "."], "h": {"id": "C0247025", "name": "C0247025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [4, 5]}}
{"token": ["However", ",", "in", "contrast", "to", "papain", "that", "degrades", "CD55", ",", "and", "C0962754#ent", "<e1>", "that", "fails", "to", "release", "CD55", ",", "C3273828#ent", "<e2>", "released", "intact", "CD55", "from", "ECM", "."], "h": {"id": "C0962754", "name": "C0962754#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3273828", "name": "C3273828#ent", "pos": [19, 20]}}
{"token": ["By", "reduction", "of", "C1826618#ent", "<e1>", "or", "C0534519#ent", "<e2>", "expression", "we", "unraveled", "that", "C1826618#ent", "<e1>", "primarily", "controls", "apoptosis", "caused", "by", "changes", "in", "calcium", "homeostasis", "C0534519#ent", "<e2>", "has", "a", "main", "role", "in", "programmed", "cell", "death", "induced", "by", "protein", "misfolding"], "h": {"id": "C1826618", "name": "C1826618#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [6, 7]}}
{"token": ["The", "atypical", "respiratory", "pathogens", "Chlamydia", "pneumoniae", "Mycoplasma", "pneumoniae", "Legionella", "pneumophila", "now", "recognised", "as", "a", "significant", "cause", "of", "acute", "respiratory-tract", "infections", "implicated", "in", "C0694549#ent", "<e1>", "acute", "exacerbations", "chronic", "bronchitis", "asthma", ",", "and", "less", "frequently", ",", "C0581381#ent", "<e2>"], "h": {"id": "C0694549", "name": "C0694549#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [34, 35]}}
{"token": ["Although", "Chlamydia", "pneumoniae", "Chlamydia", "psittaci", "well-established", "causes", "of", "C0694549#ent", "<e1>", "little", "is", "known", "about", "the", "role", "of", "Chlamydia", "species", "C0581381#ent", "<e2>"], "h": {"id": "C0694549", "name": "C0694549#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "evidence", "to", "date", "suggests", "that", "cefpodoxime", "proxetil", "has", "potential", "for", "use", "as", "stepdown", "therapy", "in", "C0694549#ent", "<e1>", "in", "abbreviated", "therapy", "courses", "in", "C0581381#ent", "<e2>"], "h": {"id": "C0694549", "name": "C0694549#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "show", "that", "RU", "38486", "has", "a", "direct", "inhibitory", "effect", "on", "tissues", "producing", "C1334092#ent", "<e1>", "and", "confirm", "the", "C2757070#ent", "<e2>", "dependency", "of", "this", "protein", "."], "h": {"id": "C1334092", "name": "C1334092#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [19, 20]}}
{"token": ["The", "dopamine", "and", "dobutamine", "effect", "on", "lymphocyte", "viability", "due", ",", "at", "least", "partially", ",", "to", "C3273109#ent", "<e1>", "engagement", ",", "as", "proved", "by", "blocking", "the", "receptor", "with", "C0033497#ent", "<e2>", "."], "h": {"id": "C3273109", "name": "C3273109#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [26, 27]}}
{"token": ["The", "catalytic", "inhibitors", "C0138965#ent", "<e1>", "CSK", ")", "and", "CSK-homologous", "kinase", "C1332757#ent", "<e2>", ")", "that", "phosphorylate", "Y(T", ")", "of", "SFKs", ",", "as", "well", "as", "the", "protein", "tyrosine", "phosphatases", "dephosphorylate", "pY(A", ")", "of", "the", "activated", "SFKs", "."], "h": {"id": "C0138965", "name": "C0138965#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332757", "name": "C1332757#ent", "pos": [10, 11]}}
{"token": ["L125R", ",", "a", "severe", "C0220701#ent", "<e1>", "missense", "mutation", "results", "in", "C2718001#ent", "<e2>", "retinal", "degeneration", "and", "ultimately", "blindness", "."], "h": {"id": "C0220701", "name": "C0220701#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2718001", "name": "C2718001#ent", "pos": [10, 11]}}
{"token": ["Primary", "fibromyalgia", "syndrome", "PFS", ")", "is", "a", "form", "of", "C0035436#ent", "<e1>", "characterized", "by", "C0231528#ent", "<e2>", "stiffness", ",", "commonly", "located", "in", "the", "neck-", ",", "shoulder-", ",", "back-", ",", "and", "pelvic", "regions"], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [13, 14]}}
{"token": ["Further", "analysis", "using", "pure", "transcription", "factors", "that", "this", "element", "at", "position", "-340", "was", "able", "to", "bind", "specifically", "to", "both", "C1417838#ent", "<e1>", "and", "to", "the", "C1417840#ent", "<e2>", "GCNF", ")", "."], "h": {"id": "C1417838", "name": "C1417838#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1417840", "name": "C1417840#ent", "pos": [24, 25]}}
{"token": ["Further", "analysis", "using", "pure", "transcription", "factors", "that", "this", "element", "at", "position", "-340", "was", "able", "to", "bind", "specifically", "to", "both", "C1417838#ent", "<e1>", "and", "to", "the", "germ", "cell", "nuclear", "factor", "C1417840#ent", "<e2>", ")", "."], "h": {"id": "C1417838", "name": "C1417838#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1417840", "name": "C1417840#ent", "pos": [28, 29]}}
{"token": ["We", "conclude", "that", "the", "abnormal", "movements", "or", "C4048158#ent", "<e1>", "associated", "with", "recovery", "from", "anaesthesia", "with", "C3178868#ent", "<e2>", "intravenous", "anaesthetics", "not", "be", "the", "result", "of", "an", "intrinsic", "proconvulsant", "action", "of", "the", "drugs", "."], "h": {"id": "C4048158", "name": "C4048158#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3178868", "name": "C3178868#ent", "pos": [15, 16]}}
{"token": ["Since", "phenylmethylsulfonyl", "fluoride", "PMSF", ")", "and", "3,4-dichloroisocoumarin", "(", "DCI", ")", "in", "addition", "to", "N-alpha-p-tosyl-L-lysine", "chloromethyl", "ketone", "(", "C0040495#ent", "<e1>", ")", "completely", "inhibited", "the", "activity", ",", "this", "C0027203#ent", "<e2>", "appears", "to", "be", "a", "trypsin-like", "serine", "protease"], "h": {"id": "C0040495", "name": "C0040495#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [26, 27]}}
{"token": ["Small", "diameter", "<", "30", "microm", ")", "cells", "had", "high", "C0006931#ent", "<e1>", "sensitivity", ",", "high", "affinity", "for", "C2744579#ent", "<e2>", ",", "and", "rapidly", "desensitizing", "ATP-activated", "current", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [16, 17]}}
{"token": ["Medium", "diameter", "30", "-", "50", "microm", ")", "cells", "had", "no", "C0006931#ent", "<e1>", "sensitivity", ",", "lower", "affinity", "for", "C2744579#ent", "<e2>", "and", "slowly", "desensitizing", "ATP-activated", "current", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [17, 18]}}
{"token": ["In", "pemphigoid", "gestationis", "PG", ")", ",", "autoantibodies", "target", "collagen", "XVII", "a", "C0021699#ent", "<e1>", "which", "is", "an", "important", "element", "in", "cutaneous", "C0812305#ent", "<e2>", "signalling", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812305", "name": "C0812305#ent", "pos": [20, 21]}}
{"token": ["Agglutinability", "of", "red", "blood", "cells", "anti-D", "increased", "remarkably", "when", "the", "cells", "were", "treated", "with", "C3540759#ent", "<e1>", "such", "as", "C0293742#ent", "<e2>", ",", "chymotrypsin", ",", "ficin", ",", "papain", ",", "pronase", "and", "trypsin", "."], "h": {"id": "C3540759", "name": "C3540759#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0293742", "name": "C0293742#ent", "pos": [18, 19]}}
{"token": ["There", "were", "no", "significant", "differences", "in", "C1332691#ent", "<e1>", "-403", "A/G", "and", "-28", "C/G", "genotype", "and", "C1706112#ent", "<e2>", "distribution", "in", "all", "the", "groups", "compared", "."], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [15, 16]}}
{"token": ["While", "the", "levels", "of", "C0041491#ent", "<e1>", "phenylethanolamine", "N-methyltransferase", "mRNA", "were", "increased", "in", "C1517800#ent", "<e2>", "rats", ",", "aromatic", "L-amino", "acid", "decarboxylase", "dopamine-beta-hydroxylase", "mRNA", "remained", "unchanged", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1517800", "name": "C1517800#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "pathways", "modulating", "the", "gene", "expression", "C0041491#ent", "<e1>", "DMN", "during", "immobilization", "(", "C1517800#ent", "<e2>", ")", "stress", "were", "also", "investigated", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1517800", "name": "C1517800#ent", "pos": [13, 14]}}
{"token": ["Interestingly", ",", "3", "families", "were", "deficient", "for", "50", "C1413902#ent", "<e1>", "while", "one", "showed", "a", "positive", "pattern", "for", "this", "C0072522#ent", "<e2>", "."], "h": {"id": "C1413902", "name": "C1413902#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [18, 19]}}
{"token": ["Late", "diagnosis", "the", "C0524489#ent", "<e1>", "lead", "to", "perforation", "and", "C0013370#ent", "<e2>", "resulting", "in", "high", "mortality", "rates"], "h": {"id": "C0524489", "name": "C0524489#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013370", "name": "C0013370#ent", "pos": [9, 10]}}
{"token": ["Three", "patients", "with", "C0524489#ent", "<e1>", "died", ",", "two", "of", "whom", "has", "massive", "gastrointestinal", "hemorrhage", "associated", "C0013370#ent", "<e2>"], "h": {"id": "C0524489", "name": "C0524489#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013370", "name": "C0013370#ent", "pos": [15, 16]}}
{"token": ["Neuronal", "gene", "transcription", "repressed", "in", "C2364020#ent", "<e1>", "the", "repressor", "element", "1", "transcription", "factor/neuron-restrictive", "silencer", "factor", "(", "C1424690#ent", "<e2>", ")", "complex", "."], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424690", "name": "C1424690#ent", "pos": [16, 17]}}
{"token": ["The", "left", "eye", "a", "43-year-old", "patients", "was", "removed", "37", "years", "after", "a", "perforating", "injury", "of", "a", "C0239377#ent", "<e1>", "absolute", "secondary", "C0017605#ent", "<e2>"], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [20, 21]}}
{"token": ["The", "eye", ",", "blind", "and", "C0239377#ent", "<e1>", "due", "to", "C0017605#ent", "<e2>", "was", "enucleated", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [9, 10]}}
{"token": ["Acute", "and", "C0239377#ent", "<e1>", "congestive", "angle", "closure", "glaucoma", "not", "seen", ",", "although", "C0017605#ent", "<e2>", "sometimes", "encountered", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [12, 13]}}
{"token": ["C0917715#ent", "<e1>", "a", "rare", "congenital", "disease", "acro-osteolysis", ",", "C0029456#ent", "<e2>", "changes", "of", "the", "spine", "and", "long", "bones", "extremities", "and", "marked", "basilar", "invagination", "an", "unusually", "deformed", "skull", "."], "h": {"id": "C0917715", "name": "C0917715#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0029456", "name": "C0029456#ent", "pos": [8, 9]}}
{"token": ["Likewise", ",", "the", "prosthetic", "group", "this", "C0014442#ent", "<e1>", "appears", "to", "be", "identical", "to", "that", "of", "C0051114#ent", "<e2>", "namely", ",", "pyrrolo", "quinoline", "quinone"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051114", "name": "C0051114#ent", "pos": [15, 16]}}
{"token": ["Lead", "exposure", "produce", "varying", "degrees", "of", "neuropsychiatric", "manifestations", "from", "discrete", "phenomena", ",", "quite", "often", "seen", "in", "children", "and", "as", "an", "C0028797#ent", "<e1>", "to", "the", "rate", "fulminant", "C0338472#ent", "<e2>"], "h": {"id": "C0028797", "name": "C0028797#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0338472", "name": "C0338472#ent", "pos": [26, 27]}}
{"token": ["C0127082#ent", "<e1>", "MMPs", ")", "accumulate", "in", "the", "tears", "of", "patients", "with", "C0010043#ent", "<e2>", "PUK", ")", "but", "it", "is", "unknown", "whether", "these", "enzymes", "have", "a", "central", "role", "in", "disease", "progression"], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010043", "name": "C0010043#ent", "pos": [11, 12]}}
{"token": ["Together", ",", "these", "data", "demonstrate", "that", "C1423950#ent", "<e1>", "is", "a", "novel", "human", "C3539590#ent", "<e2>", "the", "first", "mammalian", "alkaline", "ceramidase", "be", "identified", "as", "being", "specific", "for", "the", "hydrolysis", "of", "phytoceramide", "."], "h": {"id": "C1423950", "name": "C1423950#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539590", "name": "C3539590#ent", "pos": [12, 13]}}
{"token": ["This", "effect", "was", "mimicked", "by", "the", "selective", "C0242974#ent", "<e1>", "(+/-)-baclofen", ",", "but", "not", "by", "the", "selective", "GABAA", "receptor", "agonist", "C0062961#ent", "<e2>", "."], "h": {"id": "C0242974", "name": "C0242974#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0062961", "name": "C0062961#ent", "pos": [19, 20]}}
{"token": ["A", "combination", "of", "C0000598#ent", "<e1>", "and", "aspirin", "has", "been", "accepted", "as", "the", "standard", "C0016018#ent", "<e2>", "coronary", "stenting"], "h": {"id": "C0000598", "name": "C0000598#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [13, 14]}}
{"token": ["C0000598#ent", "<e1>", "and", "PCR", "4099", "were", "very", "potent", "C0016018#ent", "<e2>", "in", "all", "the", "models", "."], "h": {"id": "C0000598", "name": "C0000598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [8, 9]}}
{"token": ["We", "describe", "here", "a", "patient", "with", "myelodysplastic", "syndrome", "developed", "several", "life-threatening", "infections", "including", "C0275686#ent", "<e1>", ",", "tuberculosis", ",", "and", "C0023524#ent", "<e2>", "."], "h": {"id": "C0275686", "name": "C0275686#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "C1335888#ent", "<e1>", "directly", "converts", "chorismate", "into", "C0036077#ent", "<e2>", "."], "h": {"id": "C1335888", "name": "C1335888#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "C1528376#ent", "<e1>", "null", "cells", "these", "patients", "exhibited", "robust", "responses", "to", "TLR", "C0243192#ent", "<e2>", ",", "normal", "natural", "killer", "NK", ")", "cell", "activity", "and", "normal", "pDC", "functions", "."], "h": {"id": "C1528376", "name": "C1528376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [13, 14]}}
{"token": ["We", "and", "others", "have", "since", "described", "predominantly", "sound-startle", "induced", "C0270846#ent", "<e1>", "have", "been", "labelled", "'", "cataplexy", "'", ",", "abnormal", "startle", "response", "C3553291#ent", "<e2>", "."], "h": {"id": "C0270846", "name": "C0270846#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3553291", "name": "C3553291#ent", "pos": [21, 22]}}
{"token": ["The", "enzymatic", "site", "of", "sodium", "chloride", "inhibition", "of", "PGE2", "synthesis", "was", "apparently", "on", "the", "C0031672#ent", "<e1>", "assessed", "by", "C0022022#ent", "<e2>", "bradykinin", "stimulation", ",", "and", "not", "on", "cyclooxygenase", ",", "measured", "by", "arachidonic", "acid", "responsiveness"], "h": {"id": "C0031672", "name": "C0031672#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [18, 19]}}
{"token": ["The", "ability", "of", "C0812377#ent", "<e1>", "to", "inhibit", "trypsin", ",", "plasmin", ",", "C0042071#ent", "<e2>", "and", "tPA", "suggests", "that", "it", "has", "a", "role", "in", "proteolytic", "processes", "in", "vivo", "these", "enzymes", "."], "h": {"id": "C0812377", "name": "C0812377#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [11, 12]}}
{"token": ["Biochemical", "studies", "indicate", "that", "it", "is", "a", "C0030909#ent", "<e1>", "destroyed", "protein", ",", "unaffected", "by", "C0035542#ent", "<e2>", "and", "Dnase", "."], "h": {"id": "C0030909", "name": "C0030909#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [14, 15]}}
{"token": ["Enzymatic", "extraction", "proteins", "by", "C0030909#ent", "<e1>", "and", "of", "ribonucleic", "acid", "C0035542#ent", "<e2>", "after", "either", "formaldehyde", "or", "glutaraldehyde", "fixation", "rapidly", "effected", "by", "direct", "treatment", "ultrathin", "sections", "with", "solutions", "of", "the", "enzymes", "."], "h": {"id": "C0030909", "name": "C0030909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [10, 11]}}
{"token": ["Relative", "to", "water-preexposed", "groups", ",", "preexposure", "to", "C0007332#ent", "<e1>", "attenuated", "aversion", "effects", "to", "the", "C0007332#ent", "<e1>", "less", "than", "preexposure", "to", "sucrose", "attenuated", "aversion", "effects", "to", "the", "sucrose", "CS", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [7, 8]}, "relation": "chemical_structure_of", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [7, 8]}}
{"token": ["When", "the", "limiting", "amino", "acids", "C0007332#ent", "<e1>", "or", "soy", "protein", "isolate", "were", "added", "to", "a", "C0007332#ent", "<e1>", "low", "soy", "protein", "isolate", "diet", ",", "the", "urinary", "ratio", "(", "2-pyr", "+", "4-pyr)/MNA", "also", "increased", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [5, 6]}, "relation": "chemical_structure_of", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [5, 6]}}
{"token": ["The", "glycopeptides", "released", "by", "rennin", "from", "human", "C0007332#ent", "<e1>", "and", "from", "C0007332#ent", "<e1>", "been", "compared", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [7, 8]}, "relation": "chemical_structure_of", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [7, 8]}}
{"token": ["RWA", "C0851341#ent", "<e1>", "significantly", "induced", "the", "activity", "of", "C0038838#ent", "<e2>", "glutathione", "reductase", "ascorbate", "peroxidase", "higher", "levels", "in", "the", "resistant", "than", "in", "susceptible", "plants", "."], "h": {"id": "C0851341", "name": "C0851341#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [8, 9]}}
{"token": ["The", "expression", "profile", "C1568702#ent", "<e1>", "mRNA", "and", "C1419337#ent", "<e2>", "the", "OB", "coincided", "with", "the", "time", "course", "degeneration", "and", "regeneration", "of", "olfactory", "nerves", "as", "indicated", "by", "anterograde", "labeling", "of", "olfactory", "nerves", "WGA-HRP", "."], "h": {"id": "C1568702", "name": "C1568702#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419337", "name": "C1419337#ent", "pos": [7, 8]}}
{"token": ["The", "causative", "gene", "the", "reeler", "mouse", "is", "C1568702#ent", "<e1>", "which", "encodes", "C1419337#ent", "<e2>", "an", "extracellular", "molecule"], "h": {"id": "C1568702", "name": "C1568702#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419337", "name": "C1419337#ent", "pos": [11, 12]}}
{"token": ["Incubations", "with", "commercially", "available", "C0030016#ent", "<e1>", "suggest", "that", "alcohol", "and", "C0000413#ent", "<e2>", "involved", "in", "this", "oxidative", "process"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000413", "name": "C0000413#ent", "pos": [10, 11]}}
{"token": ["The", "pure", "3-alpha-hydroxysteroid", "C0030016#ent", "<e1>", "was", "completely", "devoid", "of", "C0000413#ent", "<e2>", "but", "could", "oxidize", "estradiol", "17-beta", "at", "an", "appreciable", "rate", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000413", "name": "C0000413#ent", "pos": [9, 10]}}
{"token": ["We", "have", "recently", "demonstrated", "that", "activity", "of", "red", "blood", "cell", "C0027021#ent", "<e1>", "is", "inversely", "associated", "with", "risk", "of", "cardiovascular", "events", "patients", "with", "C1956346#ent", "<e2>"], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [22, 23]}}
{"token": ["C0718160#ent", "<e1>", "has", "not", "previously", "been", "reported", "to", "be", "associated", "with", "C0002878#ent", "<e2>"], "h": {"id": "C0718160", "name": "C0718160#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [11, 12]}}
{"token": ["Although", "constitutive", "nitric", "oxide", "C1539116#ent", "<e1>", ")", "has", "been", "demonstrated", "to", "alter", "gastrointestinal", "tract", ",", "how", "C1539116#ent", "<e1>", "may", "specifically", "alter", "these", "two", "transporters", "to", "regulate", "coupled", "C1412125#ent", "<e1>", "absorption", "is", "unknown", "."], "h": {"id": "C1539116", "name": "C1539116#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [27, 28]}}
{"token": ["The", "activities", "of", "other", "C0020289#ent", "<e1>", "the", "serum", "such", "as", "C0035542#ent", "<e2>", ",", "acid", "phosphatase", "hyaluronidase", "and", "N-acetylglucosaminidase", "did", "not", "change", "significantly", "after", "the", "insecticide", "treatment", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [10, 11]}}
{"token": ["Each", "of", "the", "C0020289#ent", "<e1>", "including", "acid", "phosphatase", "beta", "glucuronidase", "cathepsin", ",", "lysozyme", ",", "and", "C0035542#ent", "<e2>", "maximum", "activities", "in", "the", "same", "gradient", "fraction", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [15, 16]}}
{"token": ["An", "increase", "in", "RNA", "synthesis", "is", "accompanied", "by", "an", "increase", "in", "the", "activities", "of", "RNA-polymerases", "II", "III", "and", "C0020289#ent", "<e1>", "a", "decrease", "in", "the", "activities", "of", "C0035542#ent", "<e2>", "and", "DNAse", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [18, 19]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [26, 27]}}
{"token": ["We", "also", "report", "structural", "and", "functional", "differences", "of", "C3889144#ent", "<e1>", "from", "other", "C0109060#ent", "<e2>", "signature", "enzymes", "."], "h": {"id": "C3889144", "name": "C3889144#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0109060", "name": "C0109060#ent", "pos": [12, 13]}}
{"token": ["Two", "proteins", "induced", "by", "either", "C2697656#ent", "<e1>", "or", "maleyl-BSA", "(", "e.g.", ",", "p57", "and", "C1418576#ent", "<e2>", ")", "show", "similar", "primary", "structure", "as", "assessed", "by", "partial", "proteolytic", "peptide", "confirming", "their", "identity", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418576", "name": "C1418576#ent", "pos": [14, 15]}}
{"token": ["The", "purpose", "of", "the", "present", "work", "was", "to", "characterize", "the", "effect", "of", "C1367702#ent", "<e1>", "MX", ")", "and", "C1367702#ent", "<e1>", "MK", ")", "treatment", "on", "rat", "hepatic", "cytochrome", "P450", "enzymes", "."], "h": {"id": "C1367702", "name": "C1367702#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1367702", "name": "C1367702#ent", "pos": [12, 13]}}
{"token": ["The", "results", "of", "multiple", "linear", "regression", "analysis", "that", "for", "obtaining", "a", "rapidly", "disintegrating", "dosage", "form", ",", "tablets", "should", "be", "prepared", "using", "an", "optimum", "concentration", "of", "C0939884#ent", "<e1>", "and", "a", "higher", "percentage", "of", "C0728803#ent", "<e2>", "."], "h": {"id": "C0939884", "name": "C0939884#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0728803", "name": "C0728803#ent", "pos": [32, 33]}}
{"token": ["We", "propose", "that", "C1419779#ent", "<e1>", "mutations", "linked", "to", "genetic", "forms", "catecholaminergic-induced", "C1419846#ent", "<e2>", "may", "alter", "the", "regulation", "of", "the", "channel", "resulting", "in", "increased", "SR", "calcium", "leak", "sympathetic", "stimulation", "."], "h": {"id": "C1419779", "name": "C1419779#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419846", "name": "C1419846#ent", "pos": [11, 12]}}
{"token": ["We", "used", "PCR", "analysis", "catalog", "the", "frequencies", "of", "C0002085#ent", "<e1>", "and", "genotypes", "for", "CYP1A1", ",", "NAT2", ",", "C1865138#ent", "<e2>", ",", "MTHFR", ",", "MTR", "(", "MS", ")", "and", "NQO*1", "in", "Arabs", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [17, 18]}}
{"token": ["Org", "GB", "did", "not", "alter", "the", "C0026454#ent", "<e1>", "pressor", "response", ",", "in", "contrast", "to", "C0002600#ent", "<e2>", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [14, 15]}}
{"token": ["The", "clinical", "outcome", "these", "5", "C0235267#ent", "<e1>", "was", "better", "than", "that", "of", "7", "other", "C0235267#ent", "<e1>", "treated", "by", "conjunctival", "flap", "procedure", ",", "lamellar", "keratoplasty", "C1154269#ent", "<e1>", "systemic", "medications"], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1154269", "name": "C1154269#ent", "pos": [24, 25]}}
{"token": ["Interferon", "alfacon-1", "from", "other", "C0751598#ent", "<e1>", "preparations", "by", "only", "a", "few", "C3539947#ent", "<e2>"], "h": {"id": "C0751598", "name": "C0751598#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [11, 12]}}
{"token": ["C0751598#ent", "<e1>", "BoINF-alpha", ")", "is", "a", "single", "polypeptide", "protein", "166", "C3539947#ent", "<e2>", "two", "disulfide", "bonds", "Cys1-Cys99", "and", "Cys29-Cys138", ")", ",", "and", "five", "stretches", "of", "alpha-helical", "structure"], "h": {"id": "C0751598", "name": "C0751598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [10, 11]}}
{"token": ["The", "1", "and", "5", "%", "yeast", "culture", "filtrate", "stimulated", "growth", "of", "Selenomonas", "ruminantium", "H18", "and", "Megasphaera", "elsdenii", "B159", "T81", "on", "5", "g/L", "of", "C2608095#ent", "<e1>", "in", "medium", "without", "C0077434#ent", "<e2>", "or", "yeast", "extract"], "h": {"id": "C2608095", "name": "C2608095#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0077434", "name": "C0077434#ent", "pos": [28, 29]}}
{"token": ["Mean", "C1427155#ent", "<e1>", "was", "reduced", "by", "both", "misoprostol", "and", "C0008783#ent", "<e2>", "in", "a", "similar", "manner", ",", "and", "there", "was", "a", "significant", "difference", "between", "the", "three", "treatment", "groups", "P", "=", "0.02", ")", "."], "h": {"id": "C1427155", "name": "C1427155#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [9, 10]}}
{"token": ["Chemokine", "receptor", "mRNA", "was", "expressed", "by", "placenta", "and", "trophoblast", "cell", "lines", "C1332699#ent", "<e1>", "by", "all", "trophoblast", "cell", "types", "whereas", "CCR2", ",", "C1413189#ent", "<e2>", ",", "and", "CX3CR1", "were", "more", "variable", "."], "h": {"id": "C1332699", "name": "C1332699#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413189", "name": "C1413189#ent", "pos": [21, 22]}}
{"token": ["A", "functional", "single", "nucleotide", "polymorphism", "SNP", ")", "of", "C1335057#ent", "<e1>", "encoding", "the", "C1335554#ent", "<e2>", "been", "reported", "to", "be", "associated", "with", "autoimmune", "disorders", "as", "rheumatoid", "arthritis", "systemic", "lupus", "erythematosus", "type", "I", "diabetes"], "h": {"id": "C1335057", "name": "C1335057#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [12, 13]}}
{"token": ["The", "genetic", "predisposition", "mainly", "confered", "by", "variations", "within", "C0017349#ent", "<e1>", "chromosome", "6p", "well", "as", "the", "C1705969#ent", "<e2>", "on", "chromosome", "2q33"], "h": {"id": "C0017349", "name": "C0017349#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [15, 16]}}
{"token": ["Angiotensin", "converting", "enzyme", "(", ")", "inhibitors", "are", "often", "administered", "as", "prodrugs", ",", "and", "their", "pharmacokinetic", "profile", "could", "be", "influenced", "by", "the", "C0029896#ent", "<e1>", "that", "accompany", "C0013604#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [25, 26]}}
{"token": ["Myocardial", "scars", "additional", "basic", "C0029896#ent", "<e1>", "and", "a", "C0013604#ent", "<e2>", "rarer", ";", "an", "extended", "region", "of", "the", "infarction", "and", "an", "anamnestically", "known", "chronic", "ischemic", "heart", "disease", "observed", "significantly", "more", "frequently", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [8, 9]}}
{"token": ["Use", "of", "PC", "and", "lyso-PC", "containing", "radiolabelled", "acyl", "chains", "separation", "of", "products", "by", "TLC", "confirmed", "the", "C1428925#ent", "<e1>", "and", "lysophospholipase", "(", "C0023816#ent", "<e2>", ")", "activities", "."], "h": {"id": "C1428925", "name": "C1428925#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [21, 22]}}
{"token": ["C0023816#ent", "<e1>", "and", "C1428925#ent", "<e2>", "activities", "were", "inhibited", "by", "dithiothreitol", ";", "N-ethylmaleimide", "inhibited", "C0023816#ent", "<e1>", "and", "LPTA", "activities", "."], "h": {"id": "C1428925", "name": "C1428925#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [0, 1]}}
{"token": ["To", "report", "a", "case", "of", "fulminant", "hepatic", "failure", "associated", "with", "use", "of", "C0054094#ent", "<e1>", ",", "a", "new", "analog", "of", "the", "phenyl", "acetate", "class", "C0003211#ent", "<e2>"], "h": {"id": "C0054094", "name": "C0054094#ent", "pos": [12, 13]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [23, 24]}}
{"token": ["We", "recently", "demonstrated", "that", "25", "mg", "of", "C0054094#ent", "<e1>", ",", "a", "new", "C0003211#ent", "<e2>", "is", "at", "least", "as", "effective", "as", "400", "mg", "of", "ibuprofen", "in", "relieving", "postoperative", "oral", "surgery", "."], "h": {"id": "C0054094", "name": "C0054094#ent", "pos": [7, 8]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}}
{"token": ["We", "hypothesize", "that", "HSP72", "is", "induced", "as", "an", "C1705964#ent", "<e1>", "the", "formation", "of", "abnormal", "C0086376#ent", "<e2>", ",", "perhaps", "targeting", "them", "for", "proteolysis", "."], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}}
{"token": ["C1418610#ent", "<e1>", "monitored", "for", "C0026848#ent", "<e2>", "."], "h": {"id": "C1418610", "name": "C1418610#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [4, 5]}}
{"token": ["C0288171#ent", "<e1>", "was", "associated", "with", "lower", "incidence", "of", "cough", "than", "C0014027#ent", "<e2>", "and", "was", "not", "associated", "with", "ankle", "oedema", "with", "any", "clinically", "significant", "drug", "interactions"], "h": {"id": "C0288171", "name": "C0288171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014027", "name": "C0014027#ent", "pos": [10, 11]}}
{"token": ["C0288171#ent", "<e1>", "reduced", "BP", "to", "a", "similar", "extent", "to", "C0014027#ent", "<e2>", "and", "atenolol", "and", "to", "a", "significantly", "greater", "extent", "than", "losartan", "."], "h": {"id": "C0288171", "name": "C0288171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014027", "name": "C0014027#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "chronic", "treatment", "the", "specific", "AT1", "angiotensin", "receptor", "antagonist", "C0288171#ent", "<e1>", ",", "or", "the", "angiotensin", "converting", "enzyme", "inhibitor", "C0014027#ent", "<e2>", ",", "were", "assessed", "in", "uninephrectomized", "fawn-hooded", "hypertensive", "(", "FHH", ")", "and", "compared", "with", "vehicle", "treatment"], "h": {"id": "C0288171", "name": "C0288171#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014027", "name": "C0014027#ent", "pos": [20, 21]}}
{"token": ["The", "present", "study", "compared", "short-term", "effects", "of", "AT(1)-receptor", "antagonist", ",", "C0288171#ent", "<e1>", "with", "the", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitor", ",", "C0014027#ent", "<e2>", "on", "systemic", "haemodynamics", "cardiac", "remodelling", "post-myocardia-infarcted", "(MI)", "rats", "."], "h": {"id": "C0288171", "name": "C0288171#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014027", "name": "C0014027#ent", "pos": [20, 21]}}
{"token": ["We", "addressed", "the", "question", "whether", "C1332789#ent", "<e1>", "regulates", "C1704657#ent", "<e2>", "phosphorylation", "in", "macrophages", ",", "and", "found", "that", "C1332789#ent", "<e1>", "induces", "FAK", "phosphorylation", "at", "all", "known", "tyrosine", "residues", "."], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332789", "name": "C1332789#ent", "pos": [5, 6]}}
{"token": ["The", "penicillin-binding", "protein", "C1705594#ent", "<e1>", ")", "patterns", "of", "the", "resistant", "and", "the", "C2987364#ent", "<e2>", "strains", "were", "comparable", "."], "h": {"id": "C1705594", "name": "C1705594#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}}
{"token": ["The", "shortening", "of", "QS2c", "and", "the", "rise", "in", "Psyst", "were", "not", "influenced", "by", "C0001640#ent", "<e1>", "blockade", "but", "were", "antagonized", "by", "C0053799#ent", "<e2>", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0053799", "name": "C0053799#ent", "pos": [20, 21]}}
{"token": ["Pathogenic", "mutations", "keratins", "K6a", "or", "C1416724#ent", "<e1>", "are", "associated", "with", "PC-1", "phenotype", "whereas", "C1416744#ent", "<e2>", "and", "K17", "mutations", "are", "associated", "with", "PC-2", "phenotype", "."], "h": {"id": "C1416724", "name": "C1416724#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416744", "name": "C1416744#ent", "pos": [13, 14]}}
{"token": ["As", "a", "consequence", ",", "vesicles", "formed", "by", "equimolar", "mixtures", "of", "SM", "with", "phosphatidylcholine", "(", "C1418943#ent", "<e1>", ")", "are", "very", "good", "targets", "for", "St", "I", "C3273406#ent", "<e2>", "."], "h": {"id": "C1418943", "name": "C1418943#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [24, 25]}}
{"token": ["The", "majority", "of", "patients", "with", "C4054226#ent", "<e1>", "one", "of", "the", "most", "common", "causes", "of", "rapidly", "progressive", "C0017658#ent", "<e2>", ",", "have", "glomerular", "disease", "part", "of", "a", "systemic", "vasculitis"], "h": {"id": "C4054226", "name": "C4054226#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [16, 17]}}
{"token": ["Protection", "against", "C0236663#ent", "<e1>", "seizures", "was", "not", "observed", "when", "C0031507#ent", "<e2>", "serum", "levels", "were", "below", "8", "micrograms/ml", "."], "h": {"id": "C0236663", "name": "C0236663#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [9, 10]}}
{"token": ["A", "meta-analysis", "of", "randomised", ",", "placebo-controlled", "trials", "the", "secondary", "prevention", "seizures", "after", "C0236663#ent", "<e1>", "lorazepam", "to", "be", "effective", ",", "whereas", "C0031507#ent", "<e2>", "was", "ineffective", "."], "h": {"id": "C0236663", "name": "C0236663#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [20, 21]}}
{"token": ["In", "this", "study", "we", "report", "that", "alpha1-antitrypsin", "(", "AAT", ")", ",", "an", "endogenous", "inhibitor", "of", "C0036734#ent", "<e1>", "inhibits", "the", "catalytic", "domain", "human", "recombinant", "C1366520#ent", "<e2>", "in", "vitro"], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1366520", "name": "C1366520#ent", "pos": [23, 24]}}
{"token": ["A", "protein", "inhibitor", "C0036734#ent", "<e1>", "binds", "to", "a", "defined", "surface", "of", "C1366520#ent", "<e2>", "was", "used", "in", "an", "affinity-based", "washing", "procedure", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366520", "name": "C1366520#ent", "pos": [11, 12]}}
{"token": ["Other", "C0870261#ent", "<e1>", "including", "tetraethylammonium", "chloride", "TEA", ")", ",", "C1414518#ent", "<e2>", "and", "quinidine", ",", "did", "not", "reduce", "the", "response", "to", "KCl", "."], "h": {"id": "C0870261", "name": "C0870261#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414518", "name": "C1414518#ent", "pos": [9, 10]}}
{"token": ["C3540534#ent", "<e1>", "or", "an", "antioxidant", ",", "C0001047#ent", "<e2>", ",", "significantly", "inhibited", "the", "TNF-alpha-induced", "NF-kappaB", "activation", "."], "h": {"id": "C3540534", "name": "C3540534#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [6, 7]}}
{"token": ["Ang", "II", "stimulated", "DNA", "synthesis", "MOLT-3", "T", "cells", ",", "which", "was", "inhibited", "by", "C3540534#ent", "<e1>", ",", "olmesartan", ",", "an", "Ang", "II", "type", "I", "receptor", "blocker", "an", "C0001047#ent", "<e2>", "NAC", ")", ",", "or", "antibodies", "directed", "against", "IL-2", "."], "h": {"id": "C3540534", "name": "C3540534#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [26, 27]}}
{"token": ["The", "drug", "was", "less", "active", "than", "C0594375#ent", "<e1>", "against", "the", "C0011523#ent", "<e2>", "was", "equipotent", "to", "etoposide", "against", "topoisomerase", "IIalpha"], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011523", "name": "C0011523#ent", "pos": [10, 11]}}
{"token": ["Although", "C0164786#ent", "<e1>", "is", "a", "C0072402#ent", "<e2>", "part", "of", "its", "regulatory", "region", "similar", "to", "the", "Src", "homology-2", "domain", "a", "structural", "motif", "of", "cytoplasmic", "tyrosine", "kinases", "functions", "in", "protein-protein", "interactions"], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [5, 6]}}
{"token": ["A", "recent", "prospective", "clinical", "study", "shown", "that", "antiviral", "therapy", "HIV", "protease", "inhibitors", "C1425021#ent", "<e1>", ")", "is", "associated", "with", "syndrome", "of", "peripheral", "fat", "wasting", "(", "C0221032#ent", "<e2>", ")", "and", "disordered", "glucose", "lipid", "metabolism", "Carr", "et", "al.", "1999", ")", "."], "h": {"id": "C1425021", "name": "C1425021#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0221032", "name": "C0221032#ent", "pos": [24, 25]}}
{"token": ["The", "effect", "of", "fasting", ",", "L-DOPA", "pretreatment", "and", "C0020456#ent", "<e1>", "the", "response", "of", "the", "rat", "vas", "deferens", "to", "C0039052#ent", "<e2>", "was", "studied", "in", "vitro"], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [18, 19]}}
{"token": ["Whether", "biliary", "cirrhosis", "unique", "in", "triggering", "C3273437#ent", "<e1>", "and", "TNF-alpha", "alterations", "and", "C0242994#ent", "<e2>", "is", "unknown", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242994", "name": "C0242994#ent", "pos": [12, 13]}}
{"token": ["Changes", "in", "C0001492#ent", "<e1>", "as", "a", "result", "of", "C0013618#ent", "<e2>", "occurs", "in", "concert", "with", "effects", "of", "cholera", "toxin", "ADPribosylation", "of", "the", "guanine", "nucleotide", "regulatory", "protein", "Ns", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [8, 9]}}
{"token": ["Gene", "silencing", "that", "C0057856#ent", "<e1>", "activity", "is", "necessary", "to", "mediate", "Ron", "degradation", "cell", "treatment", "C2826388#ent", "<e2>", "geldanamycins", "."], "h": {"id": "C0057856", "name": "C0057856#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2826388", "name": "C2826388#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "of", "transfusion/chelation", "therapy", "on", "the", "cardiovascular", "adaptations", "to", "C0581384#ent", "<e1>", "pediatric", "and", "young", "adult", "patients", "with", "C0002895#ent", "<e2>", "uncertain", "."], "h": {"id": "C0581384", "name": "C0581384#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [18, 19]}}
{"token": ["A", "66-year-old", "Japanese", "woman", "with", "C0011644#ent", "<e1>", "anemia", "and", "thrombocytopenia", "due", "to", "C0030817#ent", "<e2>", "(", "D-Pen", ")", "treatment", ",", "although", "the", "leukopenia", "was", "not", "markedly", "severe", "."], "h": {"id": "C0011644", "name": "C0011644#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [12, 13]}}
{"token": ["While", "C2936882#ent", "<e1>", "is", "known", "to", "retard", "the", "development", "of", "C0003850#ent", "<e2>", ",", "the", "exact", "mechanism", "is", "unknown", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "determine", "the", "effect", "of", "progesterone", "on", "the", "action", "of", "C2936882#ent", "<e1>", "in", "the", "development", "of", "C0003850#ent", "<e2>", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [23, 24]}}
{"token": ["Polarization", "required", "C1709402#ent", "<e1>", "the", "guanine", "nucleotide", "exchange", "factor", "Vav1", ",", "the", "C1427594#ent", "<e2>", "Cdc42", ",", "as", "well", "as", "myosin", "L", "chain", "kinase"], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1427594", "name": "C1427594#ent", "pos": [12, 13]}}
{"token": ["This", "gene", "is", "a", "structural", "but", "not", "a", "functional", "C1334043#ent", "<e1>", "of", "the", "C1412854#ent", "<e2>", "and", "mcs4(+", ")", "genes", "of", "Saccharomyces", "cerevisiae", "Schizosaccharomyces", "pombe", "respectively", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412854", "name": "C1412854#ent", "pos": [13, 14]}}
{"token": ["[Sar1,Ile8]ANG", "II", "completely", ",", "and", "C1289957#ent", "<e1>", "partially", ",", "blocked", "the", "depressor", "response", "whereas", "propranolol", ",", "C0025842#ent", "<e2>", ",", "vasopressin", "antagonists", "or", "atropine", "did", "not", "."], "h": {"id": "C1289957", "name": "C1289957#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025842", "name": "C0025842#ent", "pos": [16, 17]}}
{"token": ["If", "acute", "glomerulonephritis", "follows", "C0038395#ent", "<e1>", "to", "be", "prevented", ",", "C0021099#ent", "<e2>", "have", "to", "be", "treated", "promptly", "after", "onset", "."], "h": {"id": "C0038395", "name": "C0038395#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0021099", "name": "C0021099#ent", "pos": [10, 11]}}
{"token": ["Various", "lines", "of", "evidence", "suggest", "a", "close", "relationship", "between", "heat", "shock", "proteins", "C0034152#ent", "<e1>", ")", "and", "several", "autoimmune", "diseases", "as", "arthritis", ",", "diabetes", "and", "C0026769#ent", "<e2>"], "h": {"id": "C0034152", "name": "C0034152#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [24, 25]}}
{"token": ["This", "article", "summarizes", "the", "current", "technique", "of", "endovascular", "treatment", "of", "C0525678#ent", "<e1>", "and", "the", "clinical", "impact", "blood", "pressure", "control", "renal", "function", "and", "C0018799#ent", "<e2>"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [22, 23]}}
{"token": ["Moreover", ",", "C0525678#ent", "<e1>", "seems", "to", "affect", "C0018799#ent", "<e2>"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [7, 8]}}
{"token": ["Maxillary", "necrosis", "occur", "due", "to", "bacterial", "infections", "as", "osteomyelitis", ",", "C0042769#ent", "<e1>", "as", "herpes", "zoster", "fungal", "infections", "as", "mucormycosis", ",", "C0004030#ent", "<e2>", "etc", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [20, 21]}}
{"token": ["3-Aminobenzamide", "(", "3-AB", ")", ",", "a", "C1423108#ent", "<e1>", "inhibitor", ",", "prevents", "C0014442#ent", "<e2>", "activation", "and", "cell", "injury"], "h": {"id": "C1423108", "name": "C1423108#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["The", "reduction", "of", "delta-sleep", "is", "related", "to", "C0235946#ent", "<e1>", "the", "increase", "in", "C1839730#ent", "<e2>", "is", "explained", "by", "neurotransmitter", "disturbances", "of", "this", "disease", "."], "h": {"id": "C0235946", "name": "C0235946#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C1839730", "name": "C1839730#ent", "pos": [12, 13]}}
{"token": ["Neither", "C1700552#ent", "<e1>", "nor", "the", "photo-released", "caging", "group", "exhibited", "agonist", "or", "antagonist", "activity", "C1420120#ent", "<e2>", "and", "C1700552#ent", "<e1>", "did", "not", "induce", "transporter", "currents", "prior", "to", "photolysis", "."], "h": {"id": "C1700552", "name": "C1700552#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420120", "name": "C1420120#ent", "pos": [13, 14]}}
{"token": ["Cells", "synthesize", "nucleotides", "through", "de", "novo", "salvage", "pathways", "require", "the", "activities", "of", "C0039667#ent", "<e1>", "DHFR", ")", "and", "C0020687#ent", "<e2>", "HGPRT", ")", ",", "respectively", "."], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020687", "name": "C0020687#ent", "pos": [17, 18]}}
{"token": ["TAB2", "is", "an", "adaptator", "protein", "brigdes", "TRAF6", "(", "C1336666#ent", "<e1>", "to", "C3812805#ent", "<e2>", "(", "TGFbeta-activated", "kinase", "1", ",", "allowing", "C3812805#ent", "<e2>", "activation", "and", "subsequent", "IKK", "activation", "."], "h": {"id": "C1336666", "name": "C1336666#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3812805", "name": "C3812805#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "SOCS-3", "inhibits", "IL-1", "signal", "transduction", "by", "inhibiting", "ubiquitination", "of", "C1336666#ent", "<e1>", ",", "thus", "preventing", "association", "and", "activation", "of", "C3812805#ent", "<e2>", "."], "h": {"id": "C1336666", "name": "C1336666#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3812805", "name": "C3812805#ent", "pos": [22, 23]}}
{"token": ["The", "male", "C0038317#ent", "<e1>", "having", "either", "C3536949#ent", "<e2>", "or", "antiandrogen", "properties", ",", "were", "able", "to", "potentiate", "the", "behavioral", "effect", "of", "L-Dopa", "in", "mice", ",", "while", "female", "C0038317#ent", "<e1>", "to", "demonstrate", "this", "activity", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [6, 7]}}
{"token": ["However", ",", "upon", "separation", "of", "the", "C0038317#ent", "<e1>", "by", "chromatography", "it", "was", "found", "that", "much", "of", "the", "C3536949#ent", "<e2>", "present", "was", "in", "fact", "dihydrotestosterone", "not", "testosterone", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [17, 18]}}
{"token": ["The", "relative", "contribution", "of", "each", "C0038317#ent", "<e1>", "i.e.", "estrogen", "and", "C3536949#ent", "<e2>", ")", "on", "bone", "in", "men", "and", "the", "relationships", "among", "sex", "steroids", "changes", "in", "BMD", "and", "bone", "strength", "still", "unknown", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [10, 11]}}
{"token": ["Like", "human", "ones", ",", "monkey", "enzymes", "are", "expressed", "in", "C0038317#ent", "<e1>", "target", "tissues", ",", "where", "they", "preferentially", "glucuronidate", "C3536949#ent", "<e2>", "and", "estrogen", "metabolites", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [18, 19]}}
{"token": ["Three", "distinct", "protein", "arginine", "methyltransferases", "PRMTs", ")", "could", "be", "identified", ",", "which", "all", "exhibit", "intrinsic", "C0062776#ent", "<e1>", "when", "expressed", "as", "C1415329#ent", "<e2>", "GST", ")", "fusion", "proteins"], "h": {"id": "C0062776", "name": "C0062776#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415329", "name": "C1415329#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", "to", "the", "opposing", "action", "of", "volatile", "anesthetics", "C0700349#ent", "<e1>", "and", "phenobarbital", "inhibited", "C1704949#ent", "<e2>", "and", "GluR6", "kainate", "responses", "and", "had", "a", "much", "greater", "effect", "on", "GluR6", "receptors", "."], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [14, 15]}}
{"token": ["The", "inhibitory", "effects", "of", "C0700349#ent", "<e1>", "on", "various", "AMPA", "receptors", "expressed", "(", "GluR1", ",", "C1704949#ent", "<e2>", ",", "GluR1/3", ",", "GluR1/2", ",", "and", "GluR2/3", ")", "in", "Xenopus", "oocytes", "examined", "."], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [14, 15]}}
{"token": ["Several", "potential", "causes", "of", "orthostatic", "hypotension", "medications", ";", "non-neurogenic", "causes", "such", "as", "impaired", "venous", "return", "hypovolemia", ",", "and", "cardiac", "insufficiency", "and", "C1417685#ent", "<e1>", "causes", "such", "as", "multisystem", "atrophy", "C0011882#ent", "<e2>"], "h": {"id": "C1417685", "name": "C1417685#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0011882", "name": "C0011882#ent", "pos": [28, 29]}}
{"token": ["Currently", "available", "therapeutic", "options", "for", "C0011854#ent", "<e1>", "such", "as", "dietary", "modification", "C0359086#ent", "<e2>", "and", "insulin", ",", "have", "limitations", "of", "their", "own", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0359086", "name": "C0359086#ent", "pos": [11, 12]}}
{"token": ["To", "evaluate", "the", "effect", "of", "exenatide", "on", "clinical", "parameters", "in", "obese", "patients", "with", "C0011854#ent", "<e1>", "hyperglycemia", "is", "not", "adequately", "controlled", "despite", "treatment", "with", "C0359086#ent", "<e2>", "insulin", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0359086", "name": "C0359086#ent", "pos": [23, 24]}}
{"token": ["To", "evaluate", "the", "long-term", "efficacy", "of", "insulin", "treatment", "patients", "with", "C0011854#ent", "<e1>", "NIDDM", ")", "and", "secondary", "failure", "oral", "C0359086#ent", "<e2>"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0359086", "name": "C0359086#ent", "pos": [18, 19]}}
{"token": ["Six", "AIDS-related", "NHLs", "direct", "blood-stream", "HIV-infected", "patients", "were", "characterized", "for", "clonality", ",", "maturation", "cell", "characteristics", ",", "activation", "of", "c-myc", "C0694890#ent", "<e1>", "and", "presence", "of", "HIV", "and", "C0149678#ent", "<e2>", "genomes", "."], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [26, 27]}}
{"token": ["In", "nonactivated", "mast", "cells", "PLSCR1", "was", "found", "in", "part", "in", "lipid", "rafts", "it", "was", "further", "recruited", "after", "cell", "activation", "was", "C0669365#ent", "<e1>", "associated", "with", "Lyn", "and", "Syk", "but", "not", "with", "LAT", "or", "C0812303#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0812303", "name": "C0812303#ent", "pos": [32, 33]}}
{"token": ["Together", ",", "our", "findings", "demonstrate", "calcium-ionophore-induced", "activation", "of", "the", "C3814150#ent", "<e1>", "promoter", "by", "C1417694#ent", "<e2>", ",", "MyoD", ",", "MEF-2D", ",", "and", "p300", "in", "a", "calcineurin-dependent", "manner", "."], "h": {"id": "C3814150", "name": "C3814150#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417694", "name": "C1417694#ent", "pos": [13, 14]}}
{"token": ["Molecular", "analysis", "that", "the", "PR#1-Fuc(Gal)-GM1", "pathway", "was", "associated", "with", "C0812303#ent", "<e1>", "and", "Yes", "of", "the", "Src", "family", "C0010536#ent", "<e2>", ",", "although", "Src", "itself", "was", "not", "involved", "."], "h": {"id": "C0812303", "name": "C0812303#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [17, 18]}}
{"token": ["C0242546#ent", "<e1>", "blocked", "responses", "to", "UK-14,304", ",", "noradrenaline", "and", "C0031469#ent", "<e2>", "and", "pA2", "values", "were", "similar", "against", "each", "agonist", "."], "h": {"id": "C0242546", "name": "C0242546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [9, 10]}}
{"token": ["Prazosin", "and", "C0242546#ent", "<e1>", "competitively", "antagonized", "the", "contractions", "to", "C0031469#ent", "<e2>", "and", "BHT", "920", ",", "respectively", "."], "h": {"id": "C0242546", "name": "C0242546#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [9, 10]}}
{"token": ["A", "long-range", "restriction", "map", "of", "Xp21", ",", "encompassing", "the", "C0678933#ent", "<e1>", "McLeod", "and", "C3811755#ent", "<e2>", ",", "was", "constructed", ",", "and", "multiple", "CpG", "islands", "found", "clustered", "in", "a", "700-kb", "region", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811755", "name": "C3811755#ent", "pos": [13, 14]}}
{"token": ["It", "is", "a", "C3536890#ent", "<e1>", "the", "serpine", "group", "and", "has", "a", "specific", "action", "for", "C0699918#ent", "<e2>", "."], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "when", "present", "at", "a", "molar", "ratio", "5", "to", "1", ",", "this", "new", "C3536890#ent", "<e1>", "inactivated", "the", "activity", "of", "both", "trypsin", "and", "C0699918#ent", "<e2>", "."], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [23, 24]}}
{"token": ["Pretreatment", "with", "a", "C0205911#ent", "<e1>", "beraprost", ")", ",", "a", "proton", "pump", "inhibitor", "C2348248#ent", "<e2>", ")", "or", "a", "histamine", "H2", "receptor", "antagonist", "famotidine", ")", "prevented", "formation", "of", "gastric", "mucosal", "erosion", "while", "only", "the", "C0205911#ent", "<e1>", "inhibited", "expression", "of", "IEGs", "."], "h": {"id": "C0205911", "name": "C0205911#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2348248", "name": "C2348248#ent", "pos": [12, 13]}}
{"token": ["C0078437#ent", "<e1>", "as", "calmodulin", "antagonist", "inhibited", "the", "enzyme", "activity", "nifedipine", "as", "C0081888#ent", "<e2>", "inhibited", "the", "enzyme", "activity"], "h": {"id": "C0078437", "name": "C0078437#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0081888", "name": "C0081888#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "bucindolol", "was", "found", "to", "have", "weak", "C0162757#ent", "<e1>", "well", "as", "C3536752#ent", "<e2>", "properties", "in", "addition", "to", "its", "documented", "beta-adrenoceptor", "antagonist", "properties", "."], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536752", "name": "C3536752#ent", "pos": [12, 13]}}
{"token": ["In", "uninvolved", "epidermis", "from", "nine", "C3890176#ent", "<e1>", "subjects", ",", "the", "C3539768#ent", "<e2>", "activity", "was", "significantly", "greater", "(", "P", "less", "than", "0.01", ")", "than", "in", "nine", "controls", "."], "h": {"id": "C3890176", "name": "C3890176#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [10, 11]}}
{"token": ["C0019250#ent", "<e1>", "alpha", "1", "antitrypsin", "the", "main", "serum", "inhibitor", "of", "C3540759#ent", "<e2>", "associated", "with", "pulmonary", "emphysema", "early", "onset"], "h": {"id": "C0019250", "name": "C0019250#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540759", "name": "C3540759#ent", "pos": [10, 11]}}
{"token": ["C0023264#ent", "<e1>", "seizures", "in", "alcoholics", "(", "C0039082#ent", "<e2>", "is", "a", "rare", "neurologic", "disorder", "complicating", "the", "chronic", "abuse", "alcohol", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}}
{"token": ["Mutational", "analysis", "that", "while", "Ring1B", "is", "required", "for", "E3", "function", "C1538598#ent", "<e1>", "directs", "this", "activity", "to", "H2A", "lysine", "119", "in", "C0008546#ent", "<e2>", "."], "h": {"id": "C1538598", "name": "C1538598#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [20, 21]}}
{"token": ["Consequently", ",", "he", "gradually", "developed", "gait", "disturbance", "C2364111#ent", "<e1>", "and", "severe", "C0392699#ent", "<e2>", "in", "his", "lower", "limbs"], "h": {"id": "C2364111", "name": "C2364111#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0392699", "name": "C0392699#ent", "pos": [11, 12]}}
{"token": ["Chronic", "treatments", "either", "C0047042#ent", "<e1>", "or", "T3", "did", "not", "restore", "C4086533#ent", "<e2>", "decarboxylation", "."], "h": {"id": "C0047042", "name": "C0047042#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4086533", "name": "C4086533#ent", "pos": [10, 11]}}
{"token": ["Metabolism", "of", "C0286651#ent", "<e1>", "lactone", "by", "human", "C0023899#ent", "<e2>", "microsomes", "resulted", "in", "para-hydroxy", "and", "ortho-hydroxy", "metabolites", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}}
{"token": ["Since", "the", "discovery", "of", "the", "C0017337#ent", "<e1>", ",", "many", "mutations", "have", "been", "reported", "in", "the", "C1417784#ent", "<e2>", "patients", "with", "diverse", "ethnic", "background"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417784", "name": "C1417784#ent", "pos": [15, 16]}}
{"token": ["These", "adipocytokines", "comprise", "many", "C0127400#ent", "<e1>", "such", "as", "adiponectin", ",", "C1428933#ent", "<e2>", "(", "pre-B-cell-enhancing", "factor)/visfatin", ",", "leptin", ",", "resistin", ",", "retinol-binding", "protein-4", "others", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428933", "name": "C1428933#ent", "pos": [10, 11]}}
{"token": ["A", "total", "of", "five", "patients", "(", "ages", "10", "-", "15", "years", ")", "with", "severe", "C0156147#ent", "<e1>", "defined", "by", "the", "Pediatric", "Crohn's", "Disease", "Activity", "Index", "C3273706#ent", "<e2>", ")", "was", "enrolled", "in", "the", "study", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3273706", "name": "C3273706#ent", "pos": [24, 25]}}
{"token": ["These", "mutants", "showed", "growth", "deficiency", "minimal", "medium", "containing", "starch", "or", "C0065601#ent", "<e1>", "(", "maltose", "to", "maltoheptaose", ")", "compared", "either", "to", "the", "C2987364#ent", "<e2>", "or", "to", "growth", "on", "minimal", "medium", "containing", "glucose", "."], "h": {"id": "C0065601", "name": "C0065601#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [21, 22]}}
{"token": ["Antisense", "silencing", "of", "H1C", "and", "its", "close", "homologue", "C1415387#ent", "<e1>", "in", "plants", "that", "do", "not", "express", "C4284460#ent", "<e2>", "and", "H1B", "does", "not", "affect", "the", "characteristic", "H1A(-)/", "H1B(-", ")", "male-sterility", "phenotype", "."], "h": {"id": "C1415387", "name": "C1415387#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284460", "name": "C4284460#ent", "pos": [16, 17]}}
{"token": ["In", "pts", "with", "stable", "angina", "increased", "levels", "of", "TNF-alpha", "may", "be", "accompanied", "with", "higher", "concentrations", "of", "C1363984#ent", "<e1>", "it", "seems", "to", "be", "the", "compensatory", "mechanism", "in", "long-term", "C0004153#ent", "<e2>", "."], "h": {"id": "C1363984", "name": "C1363984#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [27, 28]}}
{"token": ["Rapid", "C0039128#ent", "<e1>", "facilitate", "case-identification", "in", "populations", "at", "high", "risk", "sexually", "transmitted", "infections", "C0036916#ent", "<e2>", ")", "."], "h": {"id": "C0039128", "name": "C0039128#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [13, 14]}}
{"token": ["Alternatively", ",", "intravesical", "administration", "a", "high", "concentration", "of", "C0013227#ent", "<e1>", ",", "such", "as", "C0006931#ent", "<e2>", "or", "resiniferatoxin", ",", "at", "the", "detrusor", "muscle", "level", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [13, 14]}}
{"token": ["Neither", "C0013227#ent", "<e1>", "had", "any", "effect", "on", "C0006931#ent", "<e2>", "induced", "coughing", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [7, 8]}}
{"token": ["The", "dissociation", "of", "nitric", "oxide", "hemoglobin", ",", "from", "isolated", "C0599220#ent", "<e1>", "of", "hemoglobin", ",", "and", "from", "C1417048#ent", "<e2>", "has", "been", "studied", "using", "dithionite", "to", "remove", "free", "nitric", "oxide"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [16, 17]}}
{"token": ["We", "have", "reported", "alternative", "splice", "variants", "cGMP-binding", "cGMP-specific", "phosphodiesterases", "PDE5A", ")", ",", "i.e.", "rat", "C1418424#ent", "<e1>", ",", "human", "C1447683#ent", "<e2>", ",", "canine", "C1447683#ent", "<e2>", "and", "C1418424#ent", "<e1>", ",", "which", "possess", "distinct", "N-terminal", "sequences"], "h": {"id": "C1447683", "name": "C1447683#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418424", "name": "C1418424#ent", "pos": [14, 15]}}
{"token": ["From", "two", "promoters", "a", "single", "C1447683#ent", "<e1>", "human", "chromosome", "4q26", "encodes", "three", "alternatively", "spliced", "isoforms", "C1418424#ent", "<e2>", "-", "3", ")", "that", "differ", "in", "the", "N-terminus", "."], "h": {"id": "C1447683", "name": "C1447683#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418424", "name": "C1418424#ent", "pos": [15, 16]}}
{"token": ["C1530423#ent", "<e1>", "CBP", ")", "serves", "as", "a", "C1425716#ent", "<e2>", "multiple", "signal", "transduction", "pathways"], "h": {"id": "C1530423", "name": "C1530423#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1425716", "name": "C1425716#ent", "pos": [7, 8]}}
{"token": ["When", "challenged", "with", "an", "ip", "lethal", "dose", "of", "C0175697#ent", "<e1>", ",", "mortality", "was", "enhanced", "in", "C0162316#ent", "<e2>", "and", "loaded", "mice", "(", "P", "=", "0.035", ")", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [15, 16]}}
{"token": ["in", "Drosophila", "Kc", "cell", "extract", ",", "C0524890#ent", "<e1>", "and", "Tra2", "recruit", "the", "SR", "protein", "C1419317#ent", "<e2>", "to", "the", "repeats", "."], "h": {"id": "C0524890", "name": "C0524890#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419317", "name": "C1419317#ent", "pos": [14, 15]}}
{"token": ["However", ",", "some", "complications", "have", "been", "reported", "such", "as", "bone", "demineralization", "to", "C0042870#ent", "<e1>", "hair", "loss", "to", "zinc", "deficiency", "hemeralopia", "from", "C1510471#ent", "<e2>"], "h": {"id": "C0042870", "name": "C0042870#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C1510471", "name": "C1510471#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "the", "data", "in", "all", "patients", "suggest", "that", "haploinsufficiency", "for", "C1420321#ent", "<e1>", "may", "not", "cause", "the", "C1843004#ent", "<e2>", "or", "causes", "milder", "disease", "."], "h": {"id": "C1420321", "name": "C1420321#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1843004", "name": "C1843004#ent", "pos": [18, 19]}}
{"token": ["The", "translocation", "fuses", "the", "API2", "gene", "the", "C1416991#ent", "<e1>", "generates", "a", "functional", "C3148863#ent", "<e2>", "transcript", "."], "h": {"id": "C1416991", "name": "C1416991#ent", "pos": [7, 8]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3148863", "name": "C3148863#ent", "pos": [12, 13]}}
{"token": ["The", "C3537142#ent", "<e1>", ",", "electrophysiologic", "and", "hemodynamic", "effects", "of", "a", "new", "antiarrhythmic", "agent", "C0050396#ent", "<e2>", ",", "were", "evaluated", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0050396", "name": "C0050396#ent", "pos": [13, 14]}}
{"token": ["In", "vertebrate", "smooth", "muscle", "calcium", "in", "conjunction", "with", "calmodulin", "activates", "an", "enzyme", ",", "C1334539#ent", "<e1>", "which", "phosphorylates", "the", "C0027120#ent", "<e2>", "the", "myosin", ",", "and", "this", "phosphorylation", "triggers", "contraction", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0027120", "name": "C0027120#ent", "pos": [18, 19]}}
{"token": ["The", "C1334539#ent", "<e1>", "at", "least", "four", "protein", "products", "two", "isoforms", "of", "the", "C0027120#ent", "<e2>", "MLCK", ")", ",", "a", "130-kDa", "MLCK", ",", "and", "telokin", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0027120", "name": "C0027120#ent", "pos": [12, 13]}}
{"token": ["Activated", "C1334539#ent", "<e1>", "then", "phosphorylates", "the", "C0027120#ent", "<e2>", "triggering", "cross-bridge", "cycling", "and", "contraction", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0027120", "name": "C0027120#ent", "pos": [6, 7]}}
{"token": ["Responses", "to", "C0002509#ent", "<e1>", "the", "catechol", "nucleus", "phenylephrine", ",", "synephrine", ",", "C0025681#ent", "<e2>", ")", "were", "potentiated", "inconsistently", "by", "the", "steroids", "and", "reserpine", "pretreatment", "reduced", "markedly", "the", "frequency", "of", "potentiated", "responses.3", "."], "h": {"id": "C0002509", "name": "C0002509#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025681", "name": "C0025681#ent", "pos": [11, 12]}}
{"token": ["Both", "C3541394#ent", "<e1>", "share", "in", "common", "some", "typical", "properties", "of", "C0054859#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054859", "name": "C0054859#ent", "pos": [10, 11]}}
{"token": ["PLC-beta", "and", "regulators", "of", "G", "protein", "signaling", "RGS", ")", "function", "as", "C2984553#ent", "<e1>", "Gq", "to", "control", "the", "amplitude", "and", "C2926735#ent", "<e2>", "of", "stimulation", "."], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [19, 20]}}
{"token": ["This", "is", "the", "first", "study", "in", "which", "C1743497#ent", "<e1>", "measured", "in", "nucleated", "cells", "the", "patients", "with", "C0022661#ent", "<e2>"], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [16, 17]}}
{"token": ["ADP", "was", "more", "potent", "against", "C1334877#ent", "<e1>", "phosphorylation", "as", "compared", "to", "autophosphorylation", ",", "while", "the", "C0033607#ent", "<e2>", "the", "opposite", "effect", "."], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [15, 16]}}
{"token": ["Treatment", "of", "macrophages", "with", "an", "NF-kappaB", "inhibitor", "pyrrolidine", "dithiocarbamate", ",", "an", "C1334877#ent", "<e1>", "phosphorylation", "inhibitor", "(", "Bay", "117082", ")", ",", "and", "C0033607#ent", "<e2>", "l-1-tosylamido-2-phenylethyl", "chloromethyl", "ketone", "and", "calpain", "inhibitor", "I", "all", "inhibited", "PGN-induced", "COX-2", "expression", "."], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [21, 22]}}
{"token": ["Peptide", "inhibitors", "caspase", "activation", "the", "C1334877#ent", "<e1>", "inhibition", "of", "apoptosis", ",", "but", "C0033607#ent", "<e2>", "serine", "proteases", "no", "effect", "on", "LNCaP", "cells", "expressing", "IkappaBalpha", "super", "repressor"], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "inhibitor", "kappaBalpha", "C1334877#ent", "<e1>", ")", "and", "IkappaBbeta", "protein", "production", "was", "not", "affected", "by", "the", "C0033607#ent", "<e2>", ",", "more", "importantly", ",", "BCG", "led", "to", "the", "rapid", "but", "transient", "induction", "of", "NF-kappaB", "activity"], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [18, 19]}}
{"token": ["The", "results", "indicated", "that", "the", "expression", "of", "C1706243#ent", "<e1>", "mRNA", "increased", "37", "%", "in", "the", "C1420342#ent", "<e2>", "patients", "'", "peripheral", "blood", "but", "the", "expression", "of", "BMPR2", "mRNA", "decreased", "57", "%", "."], "h": {"id": "C1706243", "name": "C1706243#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [15, 16]}}
{"token": ["Most", "recently", ",", "we", "showed", "that", "osmotin", ",", "which", "is", "a", "ligand", "for", "the", "C1334043#ent", "<e1>", "AdipoR", "(", "PHO36", ")", ",", "activated", "C1418898#ent", "<e2>", "via", "AdipoR", "in", "C2C12", "myocytes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418898", "name": "C1418898#ent", "pos": [22, 23]}}
{"token": ["In", "the", "present", "study", ",", "a", "C1334043#ent", "<e1>", "of", "the", "C1418898#ent", "<e2>", "gamma1-subunit", "cDNA", "with", "an", "open", "reading", "frame", "328", "amino", "acids", "identified", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418898", "name": "C1418898#ent", "pos": [10, 11]}}
{"token": ["The", "Drosophila", "melanogaster", "genome", "contains", "single", "genes", "C1334043#ent", "<e1>", "of", "the", "alpha", ",", "beta", "and", "gamma", "subunits", "C1418898#ent", "<e2>", "(", "DmAMPK", ")", "and", "of", "ACC", "(", "DmACC", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418898", "name": "C1418898#ent", "pos": [17, 18]}}
{"token": ["iPFK-2", "was", "phosphorylated", "on", "the", "C1334043#ent", "<e1>", "Ser-461", ")", "and", "activated", "by", "C1418898#ent", "<e2>", "in", "vitro"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418898", "name": "C1418898#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "signaling", "pathways", "by", "C3273507#ent", "<e1>", "clients", "is", "necessary", "for", "cell", "proliferation", "regulation", "of", "C1539078#ent", "<e2>", "apoptosis", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [15, 16]}}
{"token": ["We", "also", "investigated", "the", "release", "of", "the", "cytokines", "IL-1", ",", "IL-6", "and", "C1710304#ent", "<e1>", ",", "chemokines", "KC", "and", "MCP-1", "and", "the", "eicosanoids", "C0812309#ent", "<e2>", "PGE(2", ")", "in", "mice", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812309", "name": "C0812309#ent", "pos": [22, 23]}}
{"token": ["In", "this", "study", ",", "T.", "gondii", "stable", "transfectants", "expressing", "gp40/15", ",", "C1412409#ent", "<e1>", ",", "C1826560#ent", "<e2>", "and", "hemagglutinin", "(", "HA", ")", "tagged", "C1826560#ent", "<e2>", "were", "generated", "."], "h": {"id": "C1412409", "name": "C1412409#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1826560", "name": "C1826560#ent", "pos": [14, 15]}}
{"token": ["This", "study", "was", "conducted", "to", "investigate", "the", "association", "of", "C1420307#ent", "<e1>", "polymorphism", "with", "the", "risk", "of", "C0403719#ent", "<e2>", "."], "h": {"id": "C1420307", "name": "C1420307#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0403719", "name": "C0403719#ent", "pos": [16, 17]}}
{"token": ["Mutations", "in", "ATP7B", "lead", "to", "C0019202#ent", "<e1>", "a", "severe", "disorder", "with", "neurological", "and", "C0029166#ent", "<e2>"], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [13, 14]}}
{"token": ["C0019202#ent", "<e1>", "known", "for", "its", "C0029166#ent", "<e2>", "however", "electrocardiographic", "abnormalities", "not", "received", "much", "attention", "."], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [5, 6]}}
{"token": ["C0019202#ent", "<e1>", "presents", "with", "neurological", "or", "C0029166#ent", "<e2>"], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [6, 7]}}
{"token": ["The", "electrophysiologic", "properties", "of", "C0016229#ent", "<e1>", ",", "a", "new", "potent", "C0003195#ent", "<e2>", "are", "poorly", "defined", "."], "h": {"id": "C0016229", "name": "C0016229#ent", "pos": [4, 5]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [10, 11]}}
{"token": ["The", "analysis", "is", "now", "extended", "to", "the", "effects", "on", "the", "QT/RR", "relationship", "of", "amiodarone", "and", "C0016229#ent", "<e1>", ",", "2", "widely", "used", "C0003195#ent", "<e2>", "repolarization", "."], "h": {"id": "C0016229", "name": "C0016229#ent", "pos": [15, 16]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [21, 22]}}
{"token": ["Side", "effects", "observed", "in", "3", "children", ",", "i.e.", ",", "C2129214#ent", "<e1>", "1", "and", "transient", "elevations", "of", "GOT", "and", "C3887708#ent", "<e2>", "in", "2", "."], "h": {"id": "C2129214", "name": "C2129214#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3887708", "name": "C3887708#ent", "pos": [18, 19]}}
{"token": ["The", "intracellular", "tail", "of", "C1416387#ent", "<e1>", "shows", "sequence", "homologies", "the", "TRAF2", "binding", "motifs", "of", "C1705984#ent", "<e2>", "and", "CD40", "."], "h": {"id": "C1416387", "name": "C1416387#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705984", "name": "C1705984#ent", "pos": [14, 15]}}
{"token": ["The", "physicochemical", "properties", "of", "C0148859#ent", "<e1>", "HF", "HCl)--a", "phenanthrene", "methanol", "C0003374#ent", "<e2>", ",", "were", "determined", "practically", "in", "this", "study", "since", "such", "experimental", "values", "still", "unknown", "."], "h": {"id": "C0148859", "name": "C0148859#ent", "pos": [4, 5]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [10, 11]}}
{"token": ["The", "neurodegenerative", "diseases", "Huntington", "disease", "C0751781#ent", "<e1>", "spinocerebellar", "atrophy", "type", "3", "and", "spinal", "bulbar", "muscular", "atrophy", "caused", "by", "expansion", "of", "a", "C0392213#ent", "<e2>", "their", "respective", "gene", "products"], "h": {"id": "C0751781", "name": "C0751781#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0392213", "name": "C0392213#ent", "pos": [21, 22]}}
{"token": ["Sensitization", "of", "HCT-116/p21-/-", "cells", "to", "CDDP", "and", "C0063382#ent", "<e1>", "was", "not", "limited", "to", "the", "HCT-116", "cell", "since", "MEF", "from", "C3470429#ent", "<e2>", "knockout", "mice", "also", "more", "sensitive", "to", "these", "DNA", "crosslinking", "agents"], "h": {"id": "C0063382", "name": "C0063382#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [19, 20]}}
{"token": ["C1538915#ent", "<e1>", "levels", "were", "higher", "in", "rats", "with", "C1623038#ent", "<e2>", "than", "in", "controls", "."], "h": {"id": "C1538915", "name": "C1538915#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [8, 9]}}
{"token": ["There", "was", "a", "significantly", "increased", "prevalence", "of", "HLA", "B8", "B49", ",", "DR3", ",", "C1336643#ent", "<e1>", ",", "and", "DR10", "in", "C0339143#ent", "<e2>"], "h": {"id": "C1336643", "name": "C1336643#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [19, 20]}}
{"token": ["Many", "forms", "of", "endocrine", "therapy", "steroid-sensitive", "tumours", "involve", "regimes", "of", "steroid", "C2987634#ent", "<e1>", "deprivation", "by", "administration", "of", "C3850108#ent", "<e2>"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3850108", "name": "C3850108#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "flavonoids", "on", "the", "accumulation", "of", "daunorubicin", "were", "in", "the", "order", "of", "kaempferol", ">", "quercetin", ",", "C0052927#ent", "<e1>", ">", "myricetin", ">", "fisetin", ",", "C0066801#ent", "<e2>", "."], "h": {"id": "C0052927", "name": "C0052927#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0066801", "name": "C0066801#ent", "pos": [25, 26]}}
{"token": ["RT-PCR", "for", "mRNAs", "representing", "C1418388#ent", "<e1>", ",", "PC2", ",", "CPE", ",", "and", "C2931826#ent", "<e2>", "was", "performed", "on", "total", "RNA", "extracted", "from", "NCI", "H82", "."], "h": {"id": "C1418388", "name": "C1418388#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2931826", "name": "C2931826#ent", "pos": [12, 13]}}
{"token": ["These", "results", "indicate", "that", "C1418244#ent", "<e1>", "and", "glycodelin-A", "have", "similar", "overall", "C1510464#ent", "<e2>", "suggesting", "the", "likelihood", "that", "these", "glycoproteins", "are", "differentially", "glycosylated", "forms", "of", "very", "similar", "proteins", "."], "h": {"id": "C1418244", "name": "C1418244#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1510464", "name": "C1510464#ent", "pos": [11, 12]}}
{"token": ["These", "genes", "are", "involved", "in", "the", "protein-tyrosine", "phosphatase", "family", "the", "C1705543#ent", "<e1>", "(", "ATPases", "associated", "with", "cellular", "activities", "gene", "family", "the", "serine/threonine", "protein", "kinases", "family", "C1336849#ent", "<e2>", "mitochondrial", "function", "so", "on", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1336849", "name": "C1336849#ent", "pos": [25, 26]}}
{"token": ["C4082173#ent", "<e1>", "(", "cystic", "cavities", "the", "brain", ")", "is", "caused", "by", "C0038454#ent", "<e2>", "various", "causes", "."], "h": {"id": "C4082173", "name": "C4082173#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [11, 12]}}
{"token": ["In", "comparative", "studies", "bifonazole", "was", "significantly", "superior", "to", "placebo", "and", "at", "least", "as", "effective", "as", "alternative", "C0003308#ent", "<e1>", "clotrimazole", ",", "econazole", ",", "miconazole", ",", "C0069765#ent", "<e2>", "and", "sulconazole", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [16, 17]}, "relation": "therapeutic_class_of", "t": {"id": "C0069765", "name": "C0069765#ent", "pos": [24, 25]}}
{"token": ["Spikes", "in", "artificial", "sea", "water", "C1824114#ent", "<e1>", ")", "were", "either", "graded", "with", "increasing", "C0027867#ent", "<e2>", ",", "or", "had", "a", "well-defined", "threshold", "."], "h": {"id": "C1824114", "name": "C1824114#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [13, 14]}}
{"token": ["We", "propose", "that", "ADMA", "synthesis", "may", "be", "increased", "in", "C2316401#ent", "<e1>", "especially", "in", "C3536715#ent", "<e2>", "and", "this", "may", "explain", "part", "of", "the", "mechanism", "by", "which", "proteinuria", "increases", "cardiovascular", "morbidity", "mortality", "."], "h": {"id": "C2316401", "name": "C2316401#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536715", "name": "C3536715#ent", "pos": [13, 14]}}
{"token": ["Muricide", "was", "markedly", "inhibited", "by", "ECS", "in", "C2986870#ent", "<e1>", "and", "SP", "rats", ",", "and", "was", "moderately", "inhibited", "in", "C1839163#ent", "<e2>", "rats", ",", "while", "it", "was", "slightly", "inhibited", "in", "Raphe", "rats", "."], "h": {"id": "C2986870", "name": "C2986870#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [18, 19]}}
{"token": ["Transformation", "of", "an", "E.", "coli", "strain", "with", "a", "recombinant", "plasmid", "DNA", "C2987148#ent", "<e1>", ")", "encoding", "the", "genes", "for", "phenylalanyl-", "and", "threonyl-tRNA", "synthetases", "overproduction", "of", "these", "C3540790#ent", "<e2>", "by", "about", "100-", "and", "5-fold", ",", "respectively", "."], "h": {"id": "C2987148", "name": "C2987148#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [25, 26]}}
{"token": ["Vesicle", "formation", "was", "strongly", "inhibited", "upon", "immunodepletion", "of", "C1332163#ent", "<e1>", ",", "but", "not", "of", "AP-2", "or", "C3539540#ent", "<e2>", ",", "from", "the", "cytosol", ",", "and", "was", "restored", "by", "readdition", "of", "purified", "AP-1", "."], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539540", "name": "C3539540#ent", "pos": [16, 17]}}
{"token": ["A", "di-leucine", "motif", ",", "present", "in", "the", "cytoplasmic", "tails", "most", "melanosomal", "proteins", "and", "its", "interaction", "with", "C1332163#ent", "<e1>", "AP", ")", "complexes", ",", "specifically", "C3539540#ent", "<e2>", ",", "are", "critical", "for", "these", "events", "."], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539540", "name": "C3539540#ent", "pos": [23, 24]}}
{"token": ["Four", "independent", "modes", "in", "which", "C0002598#ent", "<e1>", "could", "bind", "to", "the", "C0919499#ent", "<e2>", "evaluated", "."], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919499", "name": "C0919499#ent", "pos": [11, 12]}}
{"token": ["Optimal", "activity", "at", "pH", "8.5", ",", ">", "or", "=", "80", "degrees", "C", ",", "and", "a", "KCl", "concentration", "of", "0.175", "M.", "This", "C0014442#ent", "<e1>", "is", "the", "most", "thermophilic", "C0072642#ent", "<e2>", "so", "far", "studied", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0072642", "name": "C0072642#ent", "pos": [27, 28]}}
{"token": ["To", "address", "these", "issues", ",", "we", "created", "mice", "transgenic", "for", "a", "bacterial", "artificial", "chromosome", "BAC", ")", "containing", "the", "gene", "for", "human", "C1425189#ent", "<e1>", "into", "which", "C0073020#ent", "<e2>", "been", "inserted", "by", "homologous", "recombination", "Langerin-Cre", ")", "."], "h": {"id": "C1425189", "name": "C1425189#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0073020", "name": "C0073020#ent", "pos": [25, 26]}}
{"token": ["In", "isolated", "rat", "pancreatic", "islets", "adenovirus-mediated", "overexpression", "of", "WT", "C1826724#ent", "<e1>", "but", "not", "other", "C1826724#ent", "<e1>", "isoforms", ",", "markedly", "increased", "c-myc", "expression", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [9, 10]}}
{"token": ["17", "beta-Estradiol", "directly", "stimulated", "the", "activity", "of", "both", "PKC", "delta", "PKC", "alpha", "but", "not", "C1826724#ent", "<e1>", "epsilon", "or", "C1826724#ent", "<e1>", "in", "a", "cell-free", "assay", "system"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [14, 15]}}
{"token": ["Recent", "studies", "have", "described", "the", "genetic", "association", "polymorphisms", "in", "C4284004#ent", "<e1>", "complex", "chronic", "inflammatory", "barrier", "diseases", "such", "as", "C0010346#ent", "<e2>", "asthma", "and", "with", "rare", "auto-inflammatory", "syndromes", "familial", "cold", "urticaria", "Muckle-Wells", "syndrome", "Blau", "syndrome"], "h": {"id": "C4284004", "name": "C4284004#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [18, 19]}}
{"token": ["Experiments", "using", "synthetic", "peptides", "within", "these", "C0086376#ent", "<e1>", "identify", "a", "chemotactic", "peptide", "C0658988#ent", "<e2>", ",", "and", "a", "chemokinetic", "peptide", ",", "GAIPG", ",", "C0658988#ent", "<e2>", "was", "identified", "as", "a", "ligand", "for", "the", "bovine", "elastin", "receptor"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0658988", "name": "C0658988#ent", "pos": [12, 13]}}
{"token": ["The", "psychiatric", "alcoholic", "spectrum", "was", "associated", "positively", "with", "infections", ",", "injuries", ",", "alcohol", "intoxication", "pancreatitis", ",", "liver", "cirrhosis", "arthritis/rheumatic", "diseases", "and", "C0013295#ent", "<e1>", "and", "negatively", "with", "malignant", "neoplasms", "myocardial", "infarction", "gallstone", "disease", "C0403719#ent", "<e2>", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0403719", "name": "C0403719#ent", "pos": [32, 33]}}
{"token": ["During", "the", "war", "period", "the", "most", "proliferated", "transmissible", "infections", "typhoid", "and", "bilious", "typhoid", "C0024530#ent", "<e1>", ",", "and", "in", "certain", "areas", "--", "C0041351#ent", "<e2>", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041351", "name": "C0041351#ent", "pos": [21, 22]}}
{"token": ["Ratios", "of", "L/T", "to", "H/T", "'", "in", "C0206061#ent", "<e1>", "heart", "diseases", "especially", "in", "cases", "with", "C0023212#ent", "<e2>", "higher", "than", "those", "in", "controls", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023212", "name": "C0023212#ent", "pos": [15, 16]}}
{"token": ["Our", "findings", "are", "consistent", "with", "specific", "regulation", "of", "mitogenesis", "by", "C0755322#ent", "<e1>", "through", "a", "pathway", "involving", "c-Src", "kinase", "independent", "by", "both", "C3714973#ent", "<e2>", "ERK", "."], "h": {"id": "C0755322", "name": "C0755322#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3714973", "name": "C3714973#ent", "pos": [21, 22]}}
{"token": ["C1334906#ent", "<e1>", ",", "another", "member", "of", "GDNF-family", "ligands", "similar", "effects", "on", "C1839729#ent", "<e2>", "as", "GDNF", "but", "the", "unrelated", "growth", "factor", "EGF", "does", "not", "."], "h": {"id": "C1334906", "name": "C1334906#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1839729", "name": "C1839729#ent", "pos": [11, 12]}}
{"token": ["C0024790#ent", "<e1>", "PNH", ")", "may", "present", "with", "C0740985#ent", "<e2>", "thrombocytopenia", "and", ",", "if", "hemoglobin", "nephropathy", "dehydration", "is", "present", ",", "azotemia", "."], "h": {"id": "C0024790", "name": "C0024790#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0740985", "name": "C0740985#ent", "pos": [7, 8]}}
{"token": ["Although", "drug-induced", "rash", "frequent", "in", "human", "immunodeficiency", "virus", "patients", ",", "C0521471#ent", "<e1>", "due", "to", "C0034283#ent", "<e2>", "has", "not", "been", "described", "previously", "."], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [14, 15]}}
{"token": ["In", "adjusted", "analyses", ",", "cimetidine", "exposure", "and", "C0034665#ent", "<e1>", "exposure", "were", "associated", "with", "increased", "risk", "of", "hospitalization", "for", "C0030305#ent", "<e2>", "as", "were", "alcohol", "abuse", "cholelithiasis", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [18, 19]}}
{"token": ["Specifically", ",", "problems", "in", "differentiating", "diagnosis", "of", "rheumatoid", "arthritis", "arthritis", "psoriatica", "C0553730#ent", "<e1>", ",", "and", "other", "C0012634#ent", "<e2>", "of", "the", "joints", "will", "receive", "special", "mention", "."], "h": {"id": "C0553730", "name": "C0553730#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [16, 17]}}
{"token": ["The", "absence", "of", "clinical", "and", "radiographic", "signs", "of", "dysplasia", "and", "calcium", "pyrophosphate", "deposition", "disease", "C0553730#ent", "<e1>", ")", "indicates", "that", "the", "basic", "C0012634#ent", "<e2>", "this", "family", "is", "osteoarthritis", "(", "OA", ")", "."], "h": {"id": "C0553730", "name": "C0553730#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [21, 22]}}
{"token": ["The", "absence", "of", "clinical", "and", "radiographic", "signs", "of", "dysplasia", "and", "C0553730#ent", "<e1>", "CPDD", ")", "indicates", "that", "the", "basic", "C0012634#ent", "<e2>", "this", "family", "is", "osteoarthritis", "(", "OA", ")", "."], "h": {"id": "C0553730", "name": "C0553730#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["A", "correlation", "existed", "in", "the", "C3887654#ent", "<e1>", "model", "between", "the", "severity", "of", "C0041349#ent", "<e2>", "the", "degree", "of", "proteinuria", "."], "h": {"id": "C3887654", "name": "C3887654#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041349", "name": "C0041349#ent", "pos": [12, 13]}}
{"token": ["Symptoms", "of", "C0405580#ent", "<e1>", ",", "and", "adrenal", "steroid", "secretion", "did", "not", "respond", "to", "exogenous", "C1337111#ent", "<e2>", "postoperatively", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [2, 3]}, "relation": "disease_has_associated_gene", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [14, 15]}}
{"token": ["C0235950#ent", "<e1>", "a", "reversible", "cause", "of", "gonadal", "dysfunction", "C0041948#ent", "<e2>", "."], "h": {"id": "C0235950", "name": "C0235950#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [8, 9]}}
{"token": ["This", "effect", "of", "NAC", "was", "blocked", "by", "the", "C1565306#ent", "<e1>", "inhibitors", "roscovitine", "and", "C0000481#ent", "<e2>", "."], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000481", "name": "C0000481#ent", "pos": [13, 14]}}
{"token": ["C0062128#ent", "<e1>", "and", "homoharringtonine", "are", "naturally", "occurring", "C0002062#ent", "<e2>", "with", "demonstrated", "antineoplastic", "activity", "certain", "types", "of", "leukemias", "in", "cell", "cultures", "experimental", "animals", "and", "initial", "clinical", "trials"], "h": {"id": "C0062128", "name": "C0062128#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [7, 8]}}
{"token": ["We", "hypothesize", "that", "C1426204#ent", "<e1>", "also", "be", "associated", "with", "abnormalities", "due", "to", "duodenal", "inflammation", "C0238340#ent", "<e2>"], "h": {"id": "C1426204", "name": "C1426204#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0238340", "name": "C0238340#ent", "pos": [14, 15]}}
{"token": ["Analysis", "of", "mRNA", "revealed", "the", "expression", "of", "C3274722#ent", "<e1>", "chimaeric", "transcripts", "in", "all", "three", "C0015674#ent", "<e2>", "tumours", "analysed", "."], "h": {"id": "C3274722", "name": "C3274722#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "demonstrate", "that", "t(12;15", ")", "translocation", ",", "and", "the", "associated", "C3274722#ent", "<e1>", "fusion", ",", "can", "antedate", "acquisition", "of", "chromosome", "polysomies", "CMN", "and", "C0015674#ent", "<e2>", "."], "h": {"id": "C3274722", "name": "C3274722#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "C3274722#ent", "<e1>", "a", "potential", "diagnostic", "marker", "C0015674#ent", "<e2>", "."], "h": {"id": "C3274722", "name": "C3274722#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [8, 9]}}
{"token": ["Their", "deduced", "amino", "acid", "sequences", "C1334043#ent", "<e1>", "to", "several", "C0002594#ent", "<e2>", ",", "and", "shared", "consensus", "sequences", "the", "pyridoxal", "phosphate-binding", "site", "lysine", "residue", "its", "surrounding", "residues", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [9, 10]}}
{"token": ["Several", "C3539947#ent", "<e1>", "among", "the", "RNases", "and", "the", "RNase-like", "domains", "of", "the", "C1335628#ent", "<e2>", "located", "in", "the", "neighborhood", "of", "the", "catalytic", "sites", "barnase", ",", "whose", "three-dimensional", "structure", "been", "resolved", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335628", "name": "C1335628#ent", "pos": [12, 13]}}
{"token": ["Their", "activities", "are", "counterbalanced", "by", "the", "acetylases", "C1538565#ent", "<e1>", "and", "p300", "and", "the", "deacetylase", "C1423062#ent", "<e2>", "."], "h": {"id": "C1538565", "name": "C1538565#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423062", "name": "C1423062#ent", "pos": [14, 15]}}
{"token": ["C0238190#ent", "<e1>", "IBM", ")", "is", "a", "chronic", ",", "progressive", "C0027121#ent", "<e2>"], "h": {"id": "C0238190", "name": "C0238190#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0027121", "name": "C0027121#ent", "pos": [9, 10]}}
{"token": ["Sporadic", "C0238190#ent", "<e1>", "s-IBM", ")", "is", "an", "C0027121#ent", "<e2>", "affecting", "elderly", "individuals", "."], "h": {"id": "C0238190", "name": "C0238190#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0027121", "name": "C0027121#ent", "pos": [7, 8]}}
{"token": ["Gradually", "developing", "C0023530#ent", "<e1>", "is", "an", "early", "stage", "a", "C0849867#ent", "<e2>", "collagen", "diseases", "leukemia", "and", "other", "neoplasias", ",", "infections", ")", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0849867", "name": "C0849867#ent", "pos": [9, 10]}}
{"token": ["C0018242#ent", "<e1>", ",", "an", "antibiotic", "used", "to", "treat", "C0011636#ent", "<e2>", ",", "was", "tested", "for", "carcinogenicity", "in", "mice", ",", "rats", "and", "hamsters", "."], "h": {"id": "C0018242", "name": "C0018242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011636", "name": "C0011636#ent", "pos": [8, 9]}}
{"token": ["Clearance", "of", "inhaled", "technetium-99m", "diethylenetriaminepentaacetate", "C0968236#ent", "<e1>", ")", "is", "a", "potential", "indicator", "of", "disease", "activity", "progression", "in", "C1800706#ent", "<e2>", "IPF", ")", "."], "h": {"id": "C0968236", "name": "C0968236#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1800706", "name": "C1800706#ent", "pos": [17, 18]}}
{"token": ["A", "Phase", "II", "prospective", "trial", "performed", "to", "study", "the", "efficacy", "of", "combination", "therapy", "C0011777#ent", "<e1>", ",", "calcitriol", "(", "1,25-dihydroxyvitamin", "D3", ",", "and", "C0079083#ent", "<e2>", "in", "patients", "with", "hormone-refractory", "prostate", "cancer", "HRPC", ")", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [22, 23]}}
{"token": ["Our", "studies", "show", "that", "C0011777#ent", "<e1>", "decreases", "transport", "of", "C0079083#ent", "<e2>", "into", "brain", "tumors"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [9, 10]}}
{"token": ["The", "rings", "are", "built", "from", "tubulin", "protofilaments", "that", "are", "bent", "by", "the", "kinesin-13", "motor", "engaged", "at", "the", "C3711161#ent", "<e1>", "step", "of", "its", "C0001473#ent", "<e2>"], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [17, 18]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [22, 23]}}
{"token": ["Elf1p", "is", "a", "non-membrane", "member", "of", "the", "C3711161#ent", "<e1>", "ABC", ")", "class", "of", "C0001473#ent", "<e2>", "and", "the", "GFP-Elf1p", "fusion", "localizes", "to", "the", "cytoplasm", "."], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [13, 14]}}
{"token": ["C3711161#ent", "<e1>", "ABC", ")", "systems", ",", "also", "called", "traffic", "C0001473#ent", "<e2>", ",", "are", "found", "in", "eukaryotes", "and", "prokaryotes", "and", "almost", "all", "participate", "in", "the", "transport", "of", "a", "wide", "variety", "of", "molecules", "."], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [9, 10]}}
{"token": ["Equally", "C0003216#ent", "<e1>", "such", "as", "cetraxate", ",", "C0061231#ent", "<e2>", "and", "sofalcone", ",", "had", "no", "effects", "histamine", "release", "from", "mast", "cells", "two", "types", "and", "gastric", "acid", "secretion", "."], "h": {"id": "C0003216", "name": "C0003216#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0061231", "name": "C0061231#ent", "pos": [7, 8]}}
{"token": ["In", "contrast", ",", "5", "minutes", "of", "inhaled", "C0667301#ent", "<e1>", "decreased", "MPAP", "without", "reducing", "C1422040#ent", "<e2>", "."], "h": {"id": "C0667301", "name": "C0667301#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422040", "name": "C1422040#ent", "pos": [13, 14]}}
{"token": ["Histological", "examination", "RIA", "were", "performed", "to", "evaluate", "medial", "thickening", "intramyocardial", "and", "renal", "arteries", "perivascular", "and", "C2001899#ent", "<e1>", "content", ",", "and", "atrial", "natriuretic", "peptide", "C1417807#ent", "<e2>", ")", "and", "IGF-I", "in", "the", "heart", ",", "respectively", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [23, 24]}}
{"token": ["The", "relationship", "between", "C3203102#ent", "<e1>", "levels", "in", "rapeseed", "(", "and", "consequently", "in", "refined", "C3541397#ent", "<e2>", ")", "and", "the", "duration", "of", "storage", "period", "was", "studied", "."], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541397", "name": "C3541397#ent", "pos": [13, 14]}}
{"token": ["Cytochrome", "P450", "CYP450", ")", "C0023837#ent", "<e1>", "enzymes", "demonstrate", "organ", "and", "cell", "specific", "expression", "and", "each", "CYP450", "enzyme", "C0597298#ent", "<e2>", "produces", "a", "distinct", "pattern", "of", "epoxyeicosatrienoic", "acids", "EETs", ")", "."], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [17, 18]}}
{"token": ["This", "paper", "reports", "that", "chemokine", "expression", "is", "increased", "in", "the", "C0023899#ent", "<e1>", "of", "patients", "with", "C0023896#ent", "<e2>", ",", "moreover", ",", "that", "distinct", "patterns", "of", "chemokine", "expression", "are", "associated", "with", "different", "inflammatory", "responses", "alcohol", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023896", "name": "C0023896#ent", "pos": [15, 16]}}
{"token": ["Our", "epidemiological", "and", "genetic", "analyses", "sporadic", "and", "familial", "retinoblastoma", "that", "an", "C0678928#ent", "<e1>", "involved", "in", "the", "C1414672#ent", "<e2>", "of", "a", "significant", "fraction", "of", "new", "bilateral", "cases", "of", "the", "disease", "."], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [16, 17]}}
{"token": ["C1420014#ent", "<e1>", "the", "conversion", "of", "C1434623#ent", "<e2>", "to", "ethanolamine", "phosphate", "a", "fatty", "aldehyde"], "h": {"id": "C1420014", "name": "C1420014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1434623", "name": "C1434623#ent", "pos": [5, 6]}}
{"token": ["The", "development", "portfolio", "of", "C0766326#ent", "<e1>", "is", "practically", "complete", "and", "approval", "for", "several", "indications", "in", "C0004238#ent", "<e2>", "may", "soon", "be", "assessed", "."], "h": {"id": "C0766326", "name": "C0766326#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [15, 16]}}
{"token": ["This", "library", "was", "subjected", "to", "a", "screen", "for", "cell", "wall", "modifications", "by", "testing", "the", "cell", "wall", "integrity", "SDS", "and", "C0108162#ent", "<e1>", "sensitivity", ")", "and", "response", "to", "C0935942#ent", "<e2>", "."], "h": {"id": "C0108162", "name": "C0108162#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0935942", "name": "C0935942#ent", "pos": [26, 27]}}
{"token": ["It", "is", "concluded", "that", "C0527306#ent", "<e1>", "exhibits", "initial", "C1883695#ent", "<e2>", "effects", ",", "followed", "by", "prolonged", ",", "insurmountable", ",", "mu-antagonist", "effects", "."], "h": {"id": "C0527306", "name": "C0527306#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1883695", "name": "C1883695#ent", "pos": [8, 9]}}
{"token": ["Effects", "of", "drugs", ",", "such", "as", "C0701454#ent", "<e1>", ",", "Neo-synephrine", ",", "aminophylline", "and", "C0034414#ent", "<e2>", ",", "have", "been", "evaluated", "and", "compared", "in", "both", "control", "and", "TAH", "calves", "."], "h": {"id": "C0701454", "name": "C0701454#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [13, 14]}}
{"token": ["Patient", "2", "a", "65-year-old", "man", "with", "pseudopolyneurtic", "form", "of", "C1704945#ent", "<e1>", ",", "who", "showed", "lower", "motor", "neuron", "signs", "without", "a", "C0234132#ent", "<e2>"], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0234132", "name": "C0234132#ent", "pos": [20, 21]}}
{"token": ["The", "extent", "of", "D2-deficit", "in", "C1704945#ent", "<e1>", "and", "MSA", "were", "within", "the", "same", "range", ",", "but", "C0234132#ent", "<e2>", "symptoms", "were", "virtually", "absent", "in", "our", "C1704945#ent", "<e1>", "patients", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0234132", "name": "C0234132#ent", "pos": [16, 17]}}
{"token": ["At", "the", "end", "of", "phase", "I", "in", "all", "tissues", "studied", ",", "total", "ascorbic", "acid", "C0003486#ent", "<e1>", ")", "concentrations", "were", "higher", "in", "Siberian", "sturgeon", "C0342895#ent", "<e2>", "diet", "AP", "in", "the", "other", "two", "groups", "."], "h": {"id": "C0003486", "name": "C0003486#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [23, 24]}}
{"token": ["This", "contrasts", "to", "the", "situation", "in", "dermatitis", "herpetiformis", "where", "both", "the", "C0015230#ent", "<e1>", "and", "the", "C0021831#ent", "<e2>", "are", "gluten", "dependent", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [15, 16]}}
{"token": ["Ten", "days", "after", "the", "transfusion", "she", "developed", "fever", "and", "C0015230#ent", "<e1>", ",", "with", "subsequent", "hepatic", "and", "C0021831#ent", "<e2>", "a", "profound", "bone", "marrow", "aplasia"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [16, 17]}}
{"token": ["Significant", "differences", "were", "attributed", "to", "the", "clinical", "use", "of", "two", "drugs", ":", "C0039925#ent", "<e1>", "in", "the", "general", "anaesthesia", "group", "and", "C0033798#ent", "<e2>", "in", "the", "spinal", "group"], "h": {"id": "C0039925", "name": "C0039925#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [20, 21]}}
{"token": ["Analysis", "of", "the", "V2", "variable", "region", "each", "16S", "rRNA", "PCR", "identified", "a", "sequence", "with", "100", "%", "nucleotide", "identity", "the", "sequences", "of", "Mycobacterium", "lepraemurium", "C0026916#ent", "<e1>", "and", "Mycobacterium", "paratuberculosis", "four", "of", "the", "specimens", "from", "cats", "with", "C0023343#ent", "<e2>"], "h": {"id": "C0026916", "name": "C0026916#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [35, 36]}}
{"token": ["Horizontal", "(", "linear", ")", "and", "C1415347#ent", "<e1>", "(", "longitudinal", "angular)", "velocities", "of", "the", "C0003460#ent", "<e2>", "were", "recorded", "using", "a", "25Hz", "video", "camera"], "h": {"id": "C1415347", "name": "C1415347#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003460", "name": "C0003460#ent", "pos": [13, 14]}}
{"token": ["Culturing", "of", "3T3-L1", "cells", "glucose", "or", "with", "cytochalasin", "B", "a", "blocker", "of", "facilitative", "glucose", "transporters", "C1705603#ent", "<e1>", ")", ",", "was", "effective", "in", "reducing", "C1334332#ent", "<e2>", "activity", "(", "P", "<", "0.05", ")", "."], "h": {"id": "C1705603", "name": "C1705603#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [23, 24]}}
{"token": ["Dexamethasone", "pretreatment", ",", "which", "is", "known", "to", "increase", "C1705603#ent", "<e1>", "expression", "in", "3T3-L1", "cells", "prevented", "the", "reduction", "of", "C1334332#ent", "<e2>", "activity", "by", "TCDD", "."], "h": {"id": "C1705603", "name": "C1705603#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [18, 19]}}
{"token": ["C0015814#ent", "<e1>", "predominant", "in", "men", ",", "whereas", "C0029442#ent", "<e2>", "with", "Looser", "'s", "zones", "were", "found", "mainly", "in", "women", "."], "h": {"id": "C0015814", "name": "C0015814#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029442", "name": "C0029442#ent", "pos": [7, 8]}}
{"token": ["Yeast", "contains", "two", "C0017337#ent", "<e1>", ",", "TPM1", "and", "TPM2", ",", "encoding", "C1420872#ent", "<e2>", ",", "either", "of", "which", "can", "provide", "an", "essential", "function", "the", "yeast", "cytoskeleton", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420872", "name": "C1420872#ent", "pos": [11, 12]}}
{"token": ["Ruthenium", "red", "not", "capable", "of", "substantial", "additional", "stimulation", "of", "C1422342#ent", "<e1>", "inhibition", "of", "calcium", "release", "the", "action", "of", "C1420357#ent", "<e2>", "."], "h": {"id": "C1422342", "name": "C1422342#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420357", "name": "C1420357#ent", "pos": [18, 19]}}
{"token": ["The", "findings", "are", "discussed", "with", "reference", "to", "C3542501#ent", "<e1>", "Guillain-Barr\u00e9", "syndrome", "in", "patients", "with", "preceding", "or", "concurrent", "C0019372#ent", "<e2>", "those", "known", "to", "cause", "lymphoproliferative", "disorders"], "h": {"id": "C3542501", "name": "C3542501#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [17, 18]}}
{"token": ["A", "16-year", "old", "boy", "had", "C0010273#ent", "<e1>", "hydrocephalus", ",", "and", "C4053961#ent", "<e2>", "."], "h": {"id": "C0010273", "name": "C0010273#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4053961", "name": "C4053961#ent", "pos": [10, 11]}}
{"token": ["AP-N", "purified", "from", "human", "prostate", "was", "irreversibly", "inhibited", "by", "low", "concentrations", "of", "C3541396#ent", "<e1>", "(", "Ki", "=", "11.2", "microM", ")", "and", "C0053355#ent", "<e2>", "."], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0053355", "name": "C0053355#ent", "pos": [21, 22]}}
{"token": ["C1367731#ent", "<e1>", "phosphorylation", "and", "activation", "was", "inhibited", "by", "expression", "of", "both", "MKP1", "and", "C1414185#ent", "<e2>", ",", "although", "MKP1", "selectivity", "toward", "C1367731#ent", "<e1>", "appeared", "significantly", "higher", "than", "that", "of", "C1414185#ent", "<e2>", "."], "h": {"id": "C1414185", "name": "C1414185#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [0, 1]}}
{"token": ["The", "interaction", "of", "HAP1", "with", "C1416692#ent", "<e1>", "demonstrated", "via", "a", "yeast", "two-hybrid", "assay", "C0537086#ent", "<e2>", "and", "coimmunoprecipitation", "."], "h": {"id": "C1416692", "name": "C1416692#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [13, 14]}}
{"token": ["C0002986#ent", "<e1>", "alpha-galactosidase", "A", "alpha-Gal", "A)", "deficiency", "an", "X-linked", "lysosomal", "storage", "disorder", "often", "leads", "to", "C0035078#ent", "<e2>", "males", "and", "occasionally", "in", "females", "."], "h": {"id": "C0002986", "name": "C0002986#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [15, 16]}}
{"token": ["Molecular", "analyses", "the", "breakpoints", "to", "ITK", "and", "C0134982#ent", "<e1>", "resulting", "in", "a", "previously", "undescribed", "expression", "of", "the", "Syk", "tyrosine", "kinase", "C1367389#ent", "<e2>", "."], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367389", "name": "C1367389#ent", "pos": [20, 21]}}
{"token": ["One", "of", "the", "C2700049#ent", "<e1>", "interactors", ",", "NUFIP1", ",", "is", "an", "C1826636#ent", "<e2>", "an", "expression", "profile", "that", "of", "C2700049#ent", "<e1>", "."], "h": {"id": "C1826636", "name": "C1826636#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2700049", "name": "C2700049#ent", "pos": [3, 4]}}
{"token": ["Rdx", "proteins", "are", "proposed", "to", "possess", "a", "C2987019#ent", "<e1>", "a", "conserved", "C1422104#ent", "<e2>", "or", "CxxU", "(", "U", "is", "Sec", ")", "motif", ",", "suggesting", "a", "redox", "function"], "h": {"id": "C2987019", "name": "C2987019#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422104", "name": "C1422104#ent", "pos": [11, 12]}}
{"token": ["This", "force", "is", "determined", "by", "the", "impact", "velocity", "of", "the", "C1337104#ent", "<e1>", "and", "the", "effective", "mass", ",", "C0427008#ent", "<e2>", ",", "and", "damping", "of", "the", "body", "at", "the", "moment", "of", "contact", "."], "h": {"id": "C1337104", "name": "C1337104#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0427008", "name": "C0427008#ent", "pos": [17, 18]}}
{"token": ["The", "metabolic", "phenotypes", "of", "patients", "with", "EMS", "for", "C0897385#ent", "<e1>", "n", "=", "17", ")", "and", "C0010980#ent", "<e2>", "acetylation", "(", "n", "=", "19", ")", "were", "determined", "and", "compared", "with", "29", "healthy", "control", "."], "h": {"id": "C0897385", "name": "C0897385#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [15, 16]}}
{"token": ["With", "the", "introduction", "of", "antiretroviral", "medications", "specifically", "C0033607#ent", "<e1>", "patients", "with", "HIV", "have", "been", "further", "noted", "to", "have", "C1867743#ent", "<e2>", "hypercoagulability", ",", "hyperlipidemia", ",", "insulin", "resistance", "fat", "redistribution", "syndrome", "increased", "tendency", "to", "myocardial", "infarction"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1867743", "name": "C1867743#ent", "pos": [18, 19]}}
{"token": ["In", "addition", "the", "expression", "of", "C1565860#ent", "<e1>", "and", "inducible", "nitric", "oxide", "synthase", "proteins", "PGE2", "generation", "and", "C3540613#ent", "<e2>", "secretion", "in", "the", "ulcerated", "stomach", "suppressed", "by", "FR167653", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540613", "name": "C3540613#ent", "pos": [16, 17]}}
{"token": ["Control", "pouches", "were", "treated", "with", "7,12-dimethylbenz[a]anthracene", "(", "C0058272#ent", "<e1>", ")", ",", "turpentine", "and", "C0727050#ent", "<e2>", "respectively", "."], "h": {"id": "C0058272", "name": "C0058272#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0727050", "name": "C0727050#ent", "pos": [13, 14]}}
{"token": ["Following", "injection", "into", "the", "PVN", ",", "C0017789#ent", "<e1>", "attenuated", "and", "C0360097#ent", "<e2>", "enhanced", "nociceptive", "spinal", "reflex", "responses", "in", "arthritic", "and", "control", "animals"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0360097", "name": "C0360097#ent", "pos": [10, 11]}}
{"token": ["Similarly", ",", "partially", "purified", "C3539768#ent", "<e1>", "horse", "seminal", "fluid", "not", "affected", "by", "antibodies", "raised", "against", "C0031667#ent", "<e2>"], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [4, 5]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [15, 16]}}
{"token": ["We", "also", "studied", "the", "effects", "of", "specific", "C3539768#ent", "<e1>", "C0031667#ent", "<e2>", ")", "inhibitor", "quinacrine", "and", "the", "specific", "C0031667#ent", "<e2>", "stimulator", "mellitin", "on", "the", "release", "of", "AA", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [7, 8]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [9, 10]}}
{"token": ["Severity", "is", "variable", "from", "less", "severe", "C0002871#ent", "<e1>", ",", "through", "thalassaemia", "intermedia", "to", "profound", "severe", "C0002871#ent", "<e1>", "(", "C0039730#ent", "<e1>", "major", ")", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0039730", "name": "C0039730#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "C0030424#ent", "<e1>", "a", "41-year-old", "Korean", "man", "who", "complains", "a", "headache", "and", "C0427055#ent", "<e2>", "of", "left", "motor", "neuron", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [14, 15]}}
{"token": ["Those", "reached", "a", "maximum", "after", "a", "60-s", "stimulation", "for", "C1368110#ent", "<e1>", "and", "phospholipase", "C", "while", "the", "other", "C0031727#ent", "<e2>", "appeared", "to", "be", "slightly", "delayed", "."], "h": {"id": "C1368110", "name": "C1368110#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["C0162566#ent", "<e1>", "PCT", ")", "is", "due", "to", "a", "partial", "defect", "of", "C0042085#ent", "<e2>", "URO-D", ")", "."], "h": {"id": "C0162566", "name": "C0162566#ent", "pos": [0, 1]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0042085", "name": "C0042085#ent", "pos": [11, 12]}}
{"token": ["A", "hepatic", "uroporphyrinogen", "decarboxylase", "defect", "a", "prerequisite", "for", "the", "development", "of", "C0162566#ent", "<e1>", "but", "other", "factors", ",", "which", "probably", "do", "not", "alter", "C0042085#ent", "<e2>", "activity", ",", "determine", "the", "clinical", "onset"], "h": {"id": "C0162566", "name": "C0162566#ent", "pos": [11, 12]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0042085", "name": "C0042085#ent", "pos": [22, 23]}}
{"token": ["A", "randomized", "double-blind", "trial", "carried", "out", "with", "C0064113#ent", "<e1>", "versus", "placebo", "in", "the", "treatment", "of", "C0700345#ent", "<e2>", "confirmed", "by", "clinical", "evaluation", "direct", "microscopic", "examination", "and", "Sabouraud", "culture", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0700345", "name": "C0700345#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "the", "clinical", "and", "mycological", "effectiveness", "oral", "C0064113#ent", "<e1>", "in", "the", "treatment", "of", "C0700345#ent", "<e2>"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0700345", "name": "C0700345#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "the", "TIMI", "II", "pilot", "study", "that", "most", "patients", "with", "C0027051#ent", "<e1>", "of", "less", "than", "or", "equal", "to", "4-hour", "duration", "treated", "with", "C0032143#ent", "<e2>", "have", "good", "ventricular", "function", "AMI.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [23, 24]}}
{"token": ["Size", "exclusion", "chromatographic", "analysis", "both", "(glyco)peptides", "I", "and", "C3273406#ent", "<e1>", "showed", "an", "apparent", "C0026691#ent", "<e2>", "of", "2.3", "and", "0.52", "microM", ",", "respectively", ",", "indicating", "that", "glycopeptide", "(", "C3273406#ent", "<e1>", ")", "has", "greater", "tendency", "for", "self-association", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "we", "have", "also", "shown", "that", "T", "cell", "blasts", "C1332416#ent", "<e1>", "PHA-induced", "AICD", "are", "memory", "CD44high", "cells", "with", "increased", "C1308278#ent", "<e2>", "and", "Bcl-xL", "expression", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1308278", "name": "C1308278#ent", "pos": [20, 21]}}
{"token": ["However", ",", "hydroxytyrosol", "administration", "decreased", "C1412468#ent", "<e1>", "increased", "total", "cholesterol", "atherosclerotic", "lesion", "areas", "circulating", "monocytes", "expressing", "C1706439#ent", "<e2>", "."], "h": {"id": "C1412468", "name": "C1412468#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706439", "name": "C1706439#ent", "pos": [16, 17]}}
{"token": ["The", "authors", "analyzed", "the", "efficiency", "of", "ECG-gated", "single-photon", "emission", "computed", "tomography", "SPECT", ")", "with", "99mTc-tetraphosmin", "in", "diagnostics", "of", "short-term", "myocardium", "stunning", "C0010068#ent", "<e1>", "patients", "with", "C0022118#ent", "<e2>"], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0022118", "name": "C0022118#ent", "pos": [25, 26]}}
{"token": ["C1420219#ent", "<e1>", "deficiency", "is", "an", "X-linked", "mental", "retardation", "disorder", "by", "mutations", "in", "the", "C1845862#ent", "<e2>", "SLC6A8", "."], "h": {"id": "C1420219", "name": "C1420219#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1845862", "name": "C1845862#ent", "pos": [13, 14]}}
{"token": ["The", "sea", "urchin", "C3814450#ent", "<e1>", "a", "member", "of", "a", "subclass", "of", "highly", "conserved", "C1415407#ent", "<e2>", "variants", "."], "h": {"id": "C3814450", "name": "C3814450#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415407", "name": "C1415407#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "show", "that", "activation", "of", "both", "these", "P2", "receptor", "leads", "to", "the", "tyrosine", "phosphorylation", "activation", "of", "both", "the", "C1413291#ent", "<e1>", "and", "p44", "forms", "of", "C0170168#ent", "<e2>", "MAPK", ")", "."], "h": {"id": "C1413291", "name": "C1413291#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [25, 26]}}
{"token": ["Bis", "IX", "p53", "accumulation", "in", "LNCaP", "(", "lymph", "node", "carcinoma", "prostate", ")", ",", "which", "expresses", "C2987364#ent", "<e1>", "p53", "that", "was", "not", "accompanied", "by", "the", "induction", "of", "C1854597#ent", "<e2>", "p21/WAF1", ",", "and", "Mdm2", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1854597", "name": "C1854597#ent", "pos": [26, 27]}}
{"token": ["The", "C0154251#ent", "<e1>", "not", "depend", "on", "the", "C2744579#ent", "<e2>", "level", ",", "but", "the", "lipid", "mobility", "affected", "by", "the", "intracellular", "C2744579#ent", "<e2>", "concentration", "."], "h": {"id": "C0154251", "name": "C0154251#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [7, 8]}}
{"token": ["Low-light", "digitized", "video", "fluorescence", "polarization", "microscopy", "used", "to", "measure", "C0154251#ent", "<e1>", "parameters", "in", "plasma", "membrane", "blebs", "single", ",", "cultured", "rat", "hepatocytes", "during", "C2744579#ent", "<e2>", "depletion", "with", "the", "metabolic", "inhibitors", "cyanide", "and", "iodoacetic", "acid"], "h": {"id": "C0154251", "name": "C0154251#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [22, 23]}}
{"token": ["C0272170#ent", "<e1>", "transiently", "increased", "C1704947#ent", "<e2>", "1", "hr", "after", "its", "removal", "and", "decreased", "C1704947#ent", "<e2>", "at", "the", "48-hr", "post-treatment", "period", "."], "h": {"id": "C0272170", "name": "C0272170#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [4, 5]}}
{"token": ["The", "MRN", "complex", "is", "also", "upstream", "of", "ATM", "and", "C1332120#ent", "<e1>", "(", "A-T-mutated", "and", "rad3-related", ")", "protein", "in", "responding", "to", "C0035064#ent", "<e2>", "that", "block", "DNA", "replication"], "h": {"id": "C1332120", "name": "C1332120#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [20, 21]}}
{"token": ["Mixed", "cryoglobulinemia", "a", "C0442893#ent", "<e1>", "almost", "always", "associated", "with", "hepatitis", "C", "virus", "infection", "characterized", "by", "purpura", "and", "C0262988#ent", "<e2>", "asthenia", ",", "arthralgias", ",", "and", "often", "renal", "and", "neurological", "involvement", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0262988", "name": "C0262988#ent", "pos": [17, 18]}}
{"token": ["C0442893#ent", "<e1>", "including", "involvement", "of", "the", "kidney", ",", "mononeuritis", "multiplex", "and", "C0262988#ent", "<e2>", "is", "treated", "with", "systemic", "glucocorticoids", "and", "cyclophosphamide", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0262988", "name": "C0262988#ent", "pos": [11, 12]}}
{"token": ["Familial", "hyperkalaemic", "hypertension", "C3469605#ent", "<e1>", ")", ",", "a", "rare", "autosomal", "dominant", "form", "of", "C0020538#ent", "<e2>", "is", "associated", "with", "hyperkalaemia", "."], "h": {"id": "C3469605", "name": "C3469605#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [13, 14]}}
{"token": ["Cycloheximide", "prevented", "and", "RU", "38486", ",", "a", "glucocorticoid", "receptor", "antagonist", "suppressed", "the", "C0011777#ent", "<e1>", "induced", "increase", "in", "C0070828#ent", "<e2>", "activity", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0070828", "name": "C0070828#ent", "pos": [17, 18]}}
{"token": ["C2350558#ent", "<e1>", "Raji", "cells", "proved", "to", "be", "suitable", "targets", "for", "C0009450#ent", "<e2>", "with", "EBV", "derived", "from", "P3HR1", "cultures", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [10, 11]}}
{"token": ["This", "is", "due", "both", "to", "the", "widespread", "use", "of", "mitomycin", "C", "importantly", "to", "the", "C0002170#ent", "<e1>", "caused", "by", "C0014582#ent", "<e2>", "being", "particularly", "disturbing", "to", "Japanese", "patients", "."], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [18, 19]}}
{"token": ["Within", "the", "same", "timeframe", ",", "no", "L-W", "rat", "developed", "a", "similar", "palpable", "C1418225#ent", "<e1>", "when", "treated", "only", "with", "C1416805#ent", "<e2>", "."], "h": {"id": "C1418225", "name": "C1418225#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416805", "name": "C1416805#ent", "pos": [18, 19]}}
{"token": ["Conversely", ",", "a", "single", "intrathecal", "injection", "with", "the", "noncompetitive", "NMDAR", "antagonist", "C0813872#ent", "<e1>", "reversed", "neuropathic", "pain", "exacerbated", "by", "the", "GR", "agonist", "C0011777#ent", "<e2>", "in", "CCI", "rats", "."], "h": {"id": "C0813872", "name": "C0813872#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [21, 22]}}
{"token": ["C0813872#ent", "<e1>", "intensifies", "morphological", "changes", "of", "the", "kidney", "induced", "by", "toxic", "doses", "C0011777#ent", "<e2>", "."], "h": {"id": "C0813872", "name": "C0813872#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}}
{"token": ["Barth", "syndrome", "an", "X-linked", "recessive", "disorder", "by", "the", "tafazzin", "(", "TAZ", ")", "C0678941#ent", "<e1>", "includes", "dilated", "cardiomyopathy", "DCM", ")", "with", "left", "ventricular", "non-compaction", "neutropenia", ",", "C1533847#ent", "<e2>", "abnormal", "mitochondria", "and", "3-methylglutaconic", "aciduria"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1533847", "name": "C1533847#ent", "pos": [25, 26]}}
{"token": ["The", "present", "study", "compared", "the", "phenolic", "and", "C2348680#ent", "<e1>", "contents", "and", "total", "antioxidant", "capacities", "C0939909#ent", "<e2>", ",", "black", "tea", "green", "tea", "and", "red", "wine"], "h": {"id": "C2348680", "name": "C2348680#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0939909", "name": "C0939909#ent", "pos": [14, 15]}}
{"token": ["The", "induction", "of", "ODC", "activity", "by", "C0256103#ent", "<e1>", "was", "specifically", "blocked", "by", "C0066380#ent", "<e2>", "MGBB", ")", ",", "a", "competitive", "inhibitor", "of", "ODC", "and", "S-adenosylmethionine", "decarboxylase", "but", "not", "by", "the", "analog", "methylglyoxal", "bis(guanylhydrazone)", "MGBG", ")", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0066380", "name": "C0066380#ent", "pos": [12, 13]}}
{"token": ["Imprinting", "of", "lyophilized", "C0764105#ent", "<e1>", "with", "indole", "or", "C0037688#ent", "<e2>", "increased", "the", "reactivity", "of", "the", "active-site", "histidine", "towards", "iodomethane", "."], "h": {"id": "C0764105", "name": "C0764105#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "the", "C1705556#ent", "<e1>", "hydrolysis", "analysis", "showed", "that", "C1333935#ent", "<e2>", "can", "release", "GP80", "at", "a", "lower", "C1705556#ent", "<e1>", "concentration", "."], "h": {"id": "C1333935", "name": "C1333935#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}}
{"token": ["C1422630#ent", "<e1>", "induction", "by", "C2697656#ent", "<e2>", "in", "C3H/HeJ", "mice", "the", "lymphocytes", "and/or", "macrophages", "of", "which", "are", "known", "to", "be", "less", "responsive", "to", "C2697656#ent", "<e2>", ",", "was", "much", "less", "than", "in", "C3H/He", "and", "ddI", "mice"], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [4, 5]}}
{"token": ["Experiments", "were", "carried", "out", "to", "study", "the", "mechanism", "of", "the", "induction", "of", "ornithine", "decarboxylase", "C1422630#ent", "<e1>", ")", "in", "mouse", "tissues", "the", "injection", "of", "a", "lipopolysaccharide", "(", "C2697656#ent", "<e2>", ")", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [26, 27]}}
{"token": ["It", "is", "concluded", "that", "C1825346#ent", "<e1>", "may", "affect", "gastrointestinal", "motility", "specific", "ghrelin", "receptors", "on", "myenteric", ",", "C0042420#ent", "<e2>", "and", "central", "neurons"], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042420", "name": "C0042420#ent", "pos": [16, 17]}}
{"token": ["The", "paper", "presents", "the", "data", "of", "examination", "of", "62", "patients", "with", "C0001314#ent", "<e1>", "the", "lung", "and", "pleura", "(", "abscess", ",", "C0014013#ent", "<e2>", ",", "pyopneumothorax", ")", "."], "h": {"id": "C0001314", "name": "C0001314#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014013", "name": "C0014013#ent", "pos": [20, 21]}}
{"token": ["In", "this", "C0001314#ent", "<e1>", "group", ",", "21", "%", "had", "C0014013#ent", "<e2>", "of", "the", "gallbladder", ",", "18", "%", "had", "gangrenous", "cholecystitis", "free", "perforation", "the", "gallbladder", ",", "and", "15", "%", "had", "subphrenic", "or", "liver", "abscesses"], "h": {"id": "C0001314", "name": "C0001314#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014013", "name": "C0014013#ent", "pos": [9, 10]}}
{"token": ["Conversely", ",", "C1421387#ent", "<e1>", "expression", "knock-down", "by", "siRNAs", "impaired", "the", "MMTV", "response", "to", "C3536949#ent", "<e2>", "."], "h": {"id": "C1421387", "name": "C1421387#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [13, 14]}}
{"token": ["Only", "when", "relatively", "higher", "C0015153#ent", "<e1>", "concentrations", "are", "present", "P450", "2C9", "C0960580#ent", "<e2>", "contribute", "as", "well", "to", "the", "bioactivation", "of", "C0015153#ent", "<e1>", "in", "the", "human", "liver", "."], "h": {"id": "C0015153", "name": "C0015153#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [11, 12]}}
{"token": ["Downregulation", "of", "intracellular", "C1260386#ent", "<e1>", "concentrations", "reversed", "deficient", "drug-induced", "hyperproduction", "of", "ROS", "and", "C1706006#ent", "<e2>", "upregulation", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [13, 14]}}
{"token": ["Four", "patients", "(", "2", "males", ";", "age", "between", "15", "and", "52", "years", ")", "presented", "with", "progressive", "headache", "with", "clinical", "evidence", "C0033845#ent", "<e1>", "in", "3", ")", "and", "C0752324#ent", "<e2>", "in", "1", ")", "."], "h": {"id": "C0033845", "name": "C0033845#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0752324", "name": "C0752324#ent", "pos": [26, 27]}}
{"token": ["We", "have", "investigated", "the", "role", "of", "C0010536#ent", "<e1>", "in", "the", "phosphorylation", "state", "and", "subcellular", "localization", "C1417695#ent", "<e2>", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417695", "name": "C1417695#ent", "pos": [15, 16]}}
{"token": ["The", "C0036557#ent", "<e1>", "antidepressant", "amitriptyline", "has", "proved", "effective", "in", "C0149931#ent", "<e2>", "prophylaxis", ",", "chronic", "tension", "headache", "and", "psychogenic", "musculoskeletal", "neuralgic", "facial", "pain"], "h": {"id": "C0036557", "name": "C0036557#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [9, 10]}}
{"token": ["C0011777#ent", "<e1>", "inhibited", "the", "basal", "transcriptional", "of", "wild-type", "C0164371#ent", "<e2>", "promoter", "and", "of", "the", "two", "mutants", "found", "in", "the", "MSI-H", "subgroup", "of", "colorectal", "tumors"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [8, 9]}}
{"token": ["This", "epitope", "sequence", "named", "OLLAS", "(", "E.", "coliOmpF", "Linker", "and", "mouse", "C1425189#ent", "<e1>", "fusion", "Sequence", ")", ",", "and", "C1418789#ent", "<e2>", "mAb", "OLLA-2", "."], "h": {"id": "C1425189", "name": "C1425189#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418789", "name": "C1418789#ent", "pos": [18, 19]}}
{"token": ["Intracerebroventricular", "infusion", "of", "C0036753#ent", "<e1>", "for", "the", "5-HT1A", ",", "C1415804#ent", "<e2>", ",", "5-HT2A", "and", "5-HT2C", "receptor", "increased", "oxytocin", "mRNA", "in", "the", "SON", "and", "PVN", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415804", "name": "C1415804#ent", "pos": [9, 10]}}
{"token": ["Sequence", "analysis", "reverse-transcriptional", "polymerase", "chain", "reaction", "product", "a", "novel", "variant", "form", "of", "C3639966#ent", "<e1>", "transcript", "in", "which", "MLL", "exon", "10", "fused", "to", "C1427925#ent", "<e2>", "exon", "3"], "h": {"id": "C3639966", "name": "C3639966#ent", "pos": [12, 13]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1427925", "name": "C1427925#ent", "pos": [22, 23]}}
{"token": ["Both", "the", "apoptosis", "and", "the", "DNA", "synthesis", "mediated", "by", "the", "p21", "activated", "kinase", "PAK3", ",", "a", "C0072402#ent", "<e1>", "interacts", "with", "C1364818#ent", "<e2>", "."], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [20, 21]}}
{"token": ["However", ",", "C0008294#ent", "<e1>", "and", "lisinopril", "were", "more", "effective", "at", "preventing", "C0018802#ent", "<e2>", "whereas", "amlodipine", "and", "C0008294#ent", "<e1>", "were", "more", "effective", "than", "lisinopril", "at", "preventing", "stroke", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0008294", "name": "C0008294#ent", "pos": [2, 3]}}
{"token": ["CONCLUSION", ":", "Results", "of", "the", "validation", "process", "supported", "findings", "of", "increased", "C0018802#ent", "<e1>", "the", "ALLHAT", "doxazosin", "treatment", "arm", "compared", "to", "the", "C0008294#ent", "<e2>", "treatment", "arm"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0008294", "name": "C0008294#ent", "pos": [21, 22]}}
{"token": ["Our", "findings", "reveal", "that", "p55", "alpha", "and/or", "C1423613#ent", "<e1>", "required", "for", "survival", ",", "but", "not", "for", "development", "of", "C0020616#ent", "<e2>", ",", "in", "mice", "lacking", "p85", "alpha"], "h": {"id": "C1423613", "name": "C1423613#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [18, 19]}}
{"token": ["Whereas", "C1313497#ent", "<e1>", "expressed", "in", "early", "to", "mid-gestation", ",", "the", "expression", "of", "C1333877#ent", "<e2>", "in", "mid-", "to", "late", "gestation"], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1333877", "name": "C1333877#ent", "pos": [12, 13]}}
{"token": ["A", "second", "approach", "to", "this", "issue", "consisted", "of", "cytoplasmic", "loading", "of", "tumor", "target", "cells", "aprotinin", ",", "a", "macromolecular", "protease", "inhibitor", "to", "inhibit", "C1313497#ent", "<e1>", "probably", "other", "C1333877#ent", "<e2>", "."], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [22, 23]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1333877", "name": "C1333877#ent", "pos": [26, 27]}}
{"token": ["Immunosuppressive", "treatment", "not", "been", "proven", "to", "be", "effective", ";", "it", "appears", "to", "be", "indicated", "in", "the", "overlap", "syndrome", "C0241910#ent", "<e1>", "may", "be", "harmful", "in", "C0008311#ent", "<e2>"], "h": {"id": "C0241910", "name": "C0241910#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [24, 25]}}
{"token": ["In", "C0392514#ent", "<e1>", "GH", ")", ",", "excess", "C1166521#ent", "<e2>", "is", "deposited", "in", "parenchymal", "cells", "whereas", "little", "C1166521#ent", "<e2>", "is", "found", "in", "reticuloendothelial", "(", "RE", ")", "cells", "until", "the", "later", "stages", "of", "the", "disease", "."], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [7, 8]}}
{"token": ["Forms", "of", "vasculitis", "which", "frequently", "have", "skin", "changes", "include", "leukocytoclastic", "angiitis", "LcV", ")", ",", "Henoch-Sch\u00f6nlein", "purpura", "HSP", ")", ",", "C0031036#ent", "<e1>", "cPAN", ")", ",", "erythema", "elevatum", "et", "diutinum", "EED", ")", "and", "C1304408#ent", "<e2>", "UV", ")", "."], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1304408", "name": "C1304408#ent", "pos": [31, 32]}}
{"token": ["The", "RFLP-assay", "was", "compared", "with", "direct", "DNA", "sequencing", "27", "PCP", "isolates", "from", "HIV-1", "positive", "patients", "with", "a", "mixture", "of", "C1883559#ent", "<e1>", "and", "mutant", "C0082226#ent", "<e2>", "types", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0082226", "name": "C0082226#ent", "pos": [23, 24]}}
{"token": ["Biochemical", "analyses", "C3853644#ent", "<e1>", "in", "the", "developing", "cerebellum", "by", "the", "immune", "complex", "protein", "kinase", "activity", "sensitivity", "of", "the", "C0031727#ent", "<e2>", "to", "inhibition", "by", "P1,P4-di(adenosine-5')tetraphosphate", "confirmed", "that", "the", "expression", "of", "C3853644#ent", "<e1>", "coincided", "with", "the", "time", "of", "neuronal", "differentiation"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [2, 3]}}
{"token": ["Some", "anticonvulsant", "treatments", "VNS", ",", "valproate", ",", "C0006949#ent", "<e1>", ",", "lamotrigine", ",", "and", "C0060926#ent", "<e2>", ")", "have", "demonstrated", "mood", "improvement", "epilepsy", "patients", "and", "may", "have", "therapeutic", "potential", "for", "this", "patient", "population"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "we", "identified", "that", "amphiregulin", "(", "AR", ")", ",", "an", "C1705447#ent", "<e1>", "ligand", ",", "is", "an", "immediate", "early", "C0079429#ent", "<e2>", "for", "PTH", "treatment", "and", "has", "an", "important", "role", "in", "bone", "metabolism"], "h": {"id": "C1705447", "name": "C1705447#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}}
{"token": ["A", "family", "of", "loci", "homologous", "to", "the", "C1705447#ent", "<e1>", "Notch", ",", "a", "C0079429#ent", "<e2>", "involved", "in", "neurogenesis", ",", "have", "been", "identified", "in", "D.", "melanogaster", "."], "h": {"id": "C1705447", "name": "C1705447#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}}
{"token": ["We", "suggest", "that", "C3812755#ent", "<e1>", "does", "not", "act", "in", "combination", "with", "p53", "in", "the", "C1413014#ent", "<e2>", "and", "U373", "glioma", "cell", "lines", ",", "inducing", "apoptosis", "and", "cell", "cycle", "arrest"], "h": {"id": "C3812755", "name": "C3812755#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413014", "name": "C1413014#ent", "pos": [14, 15]}}
{"token": ["Major", "drugs", "which", "induce", "C1254351#ent", "<e1>", "nephrotoxicity", "are", "antibiotics", ",", "C0003211#ent", "<e2>", ",", "radiocontrast", "media", "anticancer", "drug", "antirheumatic", "drug"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}}
{"token": ["Three", "classes", "of", "C1254351#ent", "<e1>", "were", "examined", ":", "beta-adrenoceptor", "antagonists", "C0003211#ent", "<e2>", "dihydropyridine", "calcium", "antagonists", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}}
{"token": ["The", "oral", "administration", "C0074554#ent", "<e1>", "improved", "the", "results", "of", "C1420423#ent", "<e2>", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [9, 10]}}
{"token": ["The", "intermediates", "in", "cholesterol", "synthesis", "mevalonate", "and", "geranylgeraniol", ",", "partially", "reverse", "the", "effects", "of", "C0074554#ent", "<e1>", "on", "the", "C1420423#ent", "<e2>", "conversion", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [18, 19]}}
{"token": ["HepG2", "cells", "converted", "C1420423#ent", "<e1>", "and", "alpha-LNA", ",", "but", "C0074554#ent", "<e2>", "increased", "significantly", "only", "the", "conversion", "of", "C1420423#ent", "<e1>", "(", "9.5+/-1.9", "%", "versus", "23.8+/-5.1", "%", ",", "p<0.02", ")", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [3, 4]}}
{"token": ["In", "fact", ",", "C0074554#ent", "<e1>", "decreased", "cholesterol", "synthesis", "enhanced", "C1420423#ent", "<e2>", "conversion", "(", "mainly", "delta5", "desaturation", ")", ",", "whereas", "curcumin", "and", "nicardipin", "decreased", "delta5", "desaturation", ",", "with", "a", "limited", "effect", "on", "cholesterol", "synthesis"], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [9, 10]}}
{"token": ["Allergic", "granulomatosis", "by", "angiitis", "(", "Churg-Strauss", "syndrome", "constitutes", "an", "unusual", "disorder", "which", "is", "characterized", "clinically", "by", "C0004096#ent", "<e1>", "hypereosinophilia", ",", "accompanied", "by", "systemic", "symptoms", "histopathologically", "and", "by", "C1318520#ent", "<e2>", "extravascular", "granulomas", "and", "tissue", "infiltration", "eosinophils", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1318520", "name": "C1318520#ent", "pos": [27, 28]}}
{"token": ["In", "case-only", "study", ",", "gene-environment", "interaction", "C1134446#ent", "<e1>", "genotypes", "with", "tobacco", ",", "C0001975#ent", "<e2>", "and", "occupational", "exposures", "not", "appear", "to", "modulate", "the", "cancer", "susceptibility"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [12, 13]}}
{"token": ["There", "is", "a", "strong", "C1419895#ent", "<e1>", "relationship", "between", "the", "two", "zebrafish", "C0017337#ent", "<e2>", "and", "the", "human", "IG", "F1R", "gene", "."], "h": {"id": "C1419895", "name": "C1419895#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["Pharmacological", "blockade", "PI3-kinase/Akt", "signaling", "or", "expression", "of", "C2713509#ent", "<e1>", "Akt", "inhibits", "nuclear", "entry", "C0812222#ent", "<e2>", ",", "increases", "cellular", "levels", "p53", ",", "and", "augments", "p53", "transcriptional", "activity"], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "C0263661#ent", "<e1>", "more", "impressive", "and", "in", "the", "first", "place", "C0029453#ent", "<e2>", "."], "h": {"id": "C0263661", "name": "C0263661#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029453", "name": "C0029453#ent", "pos": [12, 13]}}
{"token": ["Hydroxychloroquine", "may", "be", "preferred", "when", "existing", "C0263661#ent", "<e1>", "or", "a", "predisposition", "to", "C0029453#ent", "<e2>", ",", "provides", "relative", "contraindications", "to", "corticosteroid", "therapy"], "h": {"id": "C0263661", "name": "C0263661#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029453", "name": "C0029453#ent", "pos": [12, 13]}}
{"token": ["The", "C1442491#ent", "<e1>", "a", "variant", "form", "of", "the", "C1334147#ent", "<e2>", "recently", "cloned", "in", "our", "laboratory", "."], "h": {"id": "C1442491", "name": "C1442491#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334147", "name": "C1334147#ent", "pos": [8, 9]}}
{"token": ["The", "C1334147#ent", "<e1>", "expressed", "only", "in", "fetal", "collecting", "ducts", ",", "and", "hence", "the", "C1442491#ent", "<e2>", "to", "be", "complexed", "with", "the", "beta", "1", "than", "C1334147#ent", "<e1>", "human", "kidney", "."], "h": {"id": "C1442491", "name": "C1442491#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334147", "name": "C1334147#ent", "pos": [1, 2]}}
{"token": ["Pulse-chase", "immunoprecipitation", "experiments", "showed", "that", "the", "C1442491#ent", "<e1>", "more", "prominent", "in", "early", "BQ16", "precipitates", "and", "the", "C1334147#ent", "<e2>", "more", "prominent", "in", "early", "UM-A9", "precipitates", "."], "h": {"id": "C1442491", "name": "C1442491#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334147", "name": "C1334147#ent", "pos": [16, 17]}}
{"token": ["In", "most", "nonneural", "systems", "platelet-activating", "factor", "C0235480#ent", "<e1>", ")", "receptor", "effects", "are", "mediated", "by", "C0752065#ent", "<e2>", "that", "are", "often", "pertussis", "toxin-sensitive", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752065", "name": "C0752065#ent", "pos": [14, 15]}}
{"token": ["The", "efficacies", "of", "canine", "and", "porcine", "GT", "preparations", "in", "stimulating", "C0077923#ent", "<e1>", "[14C]aminopyrine", "uptake", "were", "identical", "and", "equal", "to", "those", "of", "C0039659#ent", "<e2>", "CCK8", ")", "and", "pentagastrin", "."], "h": {"id": "C0077923", "name": "C0077923#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039659", "name": "C0039659#ent", "pos": [21, 22]}}
{"token": ["Whereas", "it", "is", "well", "established", "that", "GDNF", "affects", "dopaminergic", "cell", "through", "a", "receptor", "complex", "of", "the", "C0033681#ent", "<e1>", "Ret", ",", "and", "the", "glycosylphosphatidylinositol", "(GPI)-anchored", "protein", "GFRalpha-1", ",", "C0035018#ent", "<e2>", "is", "basically", "undetectable", "in", "cortical", "neurons", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035018", "name": "C0035018#ent", "pos": [27, 28]}}
{"token": ["Pre-treatment", "with", "propranolol", "C1420423#ent", "<e1>", "resulted", "in", "a", "significant", "pressor", "response", "a", "bradycardia", "during", "C0020616#ent", "<e2>", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [14, 15]}}
{"token": ["Like", "most", "cellular", "RNA", "C0014442#ent", "<e1>", ",", "the", "bI5", "group", "I", "intron", "requires", "binding", "by", "a", "C1414509#ent", "<e2>", "fold", "correctly", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414509", "name": "C1414509#ent", "pos": [16, 17]}}
{"token": ["Two", "protease", "cascades", ",", "the", "C1334706#ent", "<e1>", "and", "the", "plasminogen", "activator/", "plasmin", "family", "C0036734#ent", "<e2>", "are", "implicated", "in", "the", "turnover", "of", "interstitial", "matrix", "proteins", "upregulated", "expression", "of", "protease", "inhibitors", "been", "observed", "in", "each", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [13, 14]}}
{"token": ["All", "samples", "were", "analyzed", "with", "the", "restriction", "enzyme", "Taq", "I", "with", "two", "DNA", "probes", "the", "5", "'", "ends", "of", "both", "C1412999#ent", "<e1>", "the", "two", "adjacent", "C1413861#ent", "<e2>"], "h": {"id": "C1412999", "name": "C1412999#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1413861", "name": "C1413861#ent", "pos": [25, 26]}}
{"token": ["The", "intergenic", "region", "C1412999#ent", "<e1>", "and", "the", "neighboring", "C1413861#ent", "<e2>", "CYP21", ",", "is", "approximately", "3028", "bp", "in", "size", "."], "h": {"id": "C1412999", "name": "C1412999#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413861", "name": "C1413861#ent", "pos": [8, 9]}}
{"token": ["The", "C3274161#ent", "<e1>", "is", "an", "C2717971#ent", "<e2>", "shares", "more", "than", "39", "%", "identical", "residues", "with", "other", "kinds", "of", "mold", "allergens"], "h": {"id": "C3274161", "name": "C3274161#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [5, 6]}}
{"token": ["In", "addition", ",", "our", "results", "suggest", "that", "the", "34", "KDa", "major", "C3274161#ent", "<e1>", "of", "A.", "oryzae", "is", "also", "an", "C2717971#ent", "<e2>"], "h": {"id": "C3274161", "name": "C3274161#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [19, 20]}}
{"token": ["ramC", ",", "ramS", "and", "ramR", "were", "essential", "for", "normal", "growth", "aerial", "hyphae", "and", "ramR", ",", "a", "C0017362#ent", "<e1>", "was", "a", "key", "C1422492#ent", "<e2>", "."], "h": {"id": "C0017362", "name": "C0017362#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [21, 22]}}
{"token": ["Although", "there", "was", "no", "clinically", "apparent", "C0019079#ent", "<e1>", ",", "pulmonary", "infiltrates", "worsened", ",", "prompting", "an", "open-lung", "biopsy", "revealed", "C0020807#ent", "<e2>"], "h": {"id": "C0019079", "name": "C0019079#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0020807", "name": "C0020807#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "the", "role", "of", "the", "squatting", "test", "in", "the", "detection", "of", "early", "C0029132#ent", "<e1>", "patients", "with", "C0011854#ent", "<e2>", "NIDDM", ")", "."], "h": {"id": "C0029132", "name": "C0029132#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "describe", "a", "case", "of", "C0029132#ent", "<e1>", "a", "patient", "with", "C0011854#ent", "<e2>"], "h": {"id": "C0029132", "name": "C0029132#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [11, 12]}}
{"token": ["C0700450#ent", "<e1>", "significantly", "inhibited", "LPS-induced", "MIP-1alpha", "and", "C1705592#ent", "<e2>", "production", "by", "THP-1", "cells", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [7, 8]}}
{"token": ["Perturbation", "of", "C0001477#ent", "<e1>", "homeostasis", "controlled", "by", "mutant", "C1415354#ent", "<e2>", "in", "photoreceptor", "cells", "result", "ultimately", "in", "degeneration", "of", "these", "cells", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415354", "name": "C1415354#ent", "pos": [8, 9]}}
{"token": ["Many", "C0812317#ent", "<e1>", "expressed", "not", "only", "RYR1", "or", "C1419779#ent", "<e2>", "but", "also", "RYR3", "."], "h": {"id": "C0812317", "name": "C0812317#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419779", "name": "C1419779#ent", "pos": [8, 9]}}
{"token": ["L-Arginine", ",", "the", "precursor", "of", "endothelium-derived", "relaxing", "factor", "(EDRF)/nitric", "oxide", "NO", ")", ",", "was", "administered", "intravenously", "in", "five", "patients", "with", "essential", "hypertension", "one", "with", "C0020545#ent", "<e1>", "one", "with", "primary", "aldosteronism", "and", "one", "with", "C0010481#ent", "<e2>"], "h": {"id": "C0020545", "name": "C0020545#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [33, 34]}}
{"token": ["C0909868#ent", "<e1>", "11beta-HSD1", ")", "mediates", "intracellular", "C0038317#ent", "<e2>", "exposure", "to", "mouse", "liver", "GR", "by", "prereceptor", "reactivation", "GCs", "and", "is", "crucially", "dependent", "on", "hexose-6-phosphate", "dehydrogenase", "NADPH", "system"], "h": {"id": "C0909868", "name": "C0909868#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [6, 7]}}
{"token": ["In", "obese", "subjects", ",", "the", "C0909868#ent", "<e1>", "11beta-HSD1", ")", "is", "increased", ",", "but", "information", "on", "C0038317#ent", "<e2>", "is", "sparse", "."], "h": {"id": "C0909868", "name": "C0909868#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [15, 16]}}
{"token": ["11beta-hydroxysteroid", "dehydrogenase", "type", "1", "C0909868#ent", "<e1>", ")", "mediates", "intracellular", "C0038317#ent", "<e2>", "exposure", "to", "mouse", "liver", "GR", "by", "prereceptor", "reactivation", "GCs", "and", "is", "crucially", "dependent", "on", "hexose-6-phosphate", "dehydrogenase", "NADPH", "system"], "h": {"id": "C0909868", "name": "C0909868#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [9, 10]}}
{"token": ["Adenylate", "cyclase", "plasma", "membranes", "inhibited", "by", "micromolar", "concentrations", "of", "C0039663#ent", "<e1>", "delta", "9-tetrahydrocannabinol", "by", "levonantradol", "and", "C0113153#ent", "<e2>", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0113153", "name": "C0113153#ent", "pos": [16, 17]}}
{"token": ["Specific", "binding", "(", "defined", "as", "total", "binding", "displaced", "by", "1", "microM", "delta", "9-tetrahydrocannabinol", "(", "C0039663#ent", "<e1>", "or", "100", "nM", "C0113153#ent", "<e2>", ")", "was", "saturable", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0113153", "name": "C0113153#ent", "pos": [19, 20]}}
{"token": ["Advanced", "C0206172#ent", "<e1>", "patients", "with", "ischemia", "and", "C0029443#ent", "<e2>", "first", "require", "diagnostics", "concerning", "polyneuropathy", ",", "C0029443#ent", "<e2>", ",", "and", "blood", "supply"], "h": {"id": "C0206172", "name": "C0206172#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [7, 8]}}
{"token": ["Pretreatment", "with", "C0012522#ent", "<e1>", ",", "low", "dose", "corticosteroids", "and", "C0000970#ent", "<e2>", "as", "well", "as", "proper", "fluid", "management", "reduced", "the", "incidence", "of", "this", "syndrome", "."], "h": {"id": "C0012522", "name": "C0012522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [9, 10]}}
{"token": ["We", "report", "a", "case", "where", "a", "young", "woman", "who", "took", "moderate", "overdose", "of", "C0012522#ent", "<e1>", "(", "625", "mg", ")", "along", "with", "C0000970#ent", "<e2>", "developed", "prolonged", "QT", "interval", "strikingly", "abnormal", "T", "waves"], "h": {"id": "C0012522", "name": "C0012522#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [21, 22]}}
{"token": ["We", "obtained", "the", "temperature", "dependences", "of", "the", "C0001473#ent", "<e1>", "ATPase", ")", "activities", "(", "C1436406#ent", "<e2>", "and", "relaxed", ")", "of", "myofibrils", "from", "a", "slow", "muscle", "which", "we", "compared", "with", "those", "from", "a", "fast", "muscle"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1436406", "name": "C1436406#ent", "pos": [13, 14]}}
{"token": ["A", "craniospinal", "pressure", "dissociation", "with", "C0270680#ent", "<e1>", "be", "involved", "in", "the", "pathogenesis", "of", "C0270697#ent", "<e2>", "and", "syncope", "."], "h": {"id": "C0270680", "name": "C0270680#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [13, 14]}}
{"token": ["The", "major", "C0072522#ent", "<e1>", "carrying", "the", "C1705443#ent", "<e2>", "epitope", "was", "shown", "to", "be", "the", "integrin", "beta1", "subunit"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705443", "name": "C1705443#ent", "pos": [6, 7]}}
{"token": ["Likewise", ",", "four", "other", "non-mucin", "C0072522#ent", "<e1>", "which", "lack", "C1705443#ent", "<e2>", "expression", "did", "not", "inhibit", "NK", "cells", "having", "levels", "of", "sialic", "acid", "were", ",", "in", "some", "cases", ",", "comparable", "to", "submaxillary", "mucin"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705443", "name": "C1705443#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "serum", "C1706170#ent", "<e1>", "determination", "using", "RIA", "was", "useful", "for", "the", "diagnosis", "of", "acute", "pancreatitis", "high", "serum", "C1706170#ent", "<e1>", "levels", "and", "the", "diagnosis", "of", "severe", "C0267963#ent", "<e1>", "low", "serum", "C1706170#ent", "<e1>", "levels", "."], "h": {"id": "C1706170", "name": "C1706170#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0267963", "name": "C0267963#ent", "pos": [27, 28]}}
{"token": ["The", "various", "clinical", "features", "of", "adult", "T-cell", "leukemia/lymphoma", "C1707163#ent", "<e1>", ")", "are", "frequently", "accompanied", "by", "C0015230#ent", "<e2>"], "h": {"id": "C1707163", "name": "C1707163#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [15, 16]}}
{"token": ["Congenital", "adrenal", "hyperplasia", "to", "21-hydroxylase", "deficiency", "a", "group", "of", "C3899989#ent", "<e1>", "the", "adrenal", "cortex", "by", "cortisol", "deficiency", "with", "or", "without", "C0268293#ent", "<e2>", "and", "androgen", "excess", "."], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268293", "name": "C0268293#ent", "pos": [20, 21]}}
{"token": ["The", "irreversible", "MAO-B", "inhibitor", "C0700467#ent", "<e1>", "was", "shown", "to", "exert", "antiparkinsonian", "activity", "especially", "in", "the", "early", "stages", "C0030567#ent", "<e2>", "."], "h": {"id": "C0700467", "name": "C0700467#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [17, 18]}}
{"token": ["At", "our", "institution", ",", "patients", "who", "undergo", "primary", "C1564278#ent", "<e1>", "performed", "with", "hypotensive", "epidural", "anesthesia", "postoperative", "C0004057#ent", "<e2>", ",", "antithromboembolic", "disease", "stockings", "and", "early", "ambulation", "a", "low", "risk", "thromboembolic", "disease"], "h": {"id": "C1564278", "name": "C1564278#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [16, 17]}}
{"token": ["Additional", "studies", "revealed", "that", "C0042671#ent", "<e1>", "efflux", "was", "accelerated", "by", "C4084714#ent", "<e2>", "compared", "with", "LLC-PK1", "."], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4084714", "name": "C4084714#ent", "pos": [10, 11]}}
{"token": ["C0008169#ent", "<e1>", "CAT", ")", "assay", "revealed", "that", "C0043167#ent", "<e2>", "toxin", "could", "inhibit", "HIV-1", "gene", "expression", "."], "h": {"id": "C0008169", "name": "C0008169#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [7, 8]}}
{"token": ["Mutation", "of", "crucial", "aspartates", "in", "site", "II", "abolished", "C1333365#ent", "<e1>", "but", "caused", "C0014442#ent", "<e2>", "to", "retain", "structure-specific", "(flap", "endonuclease)", "activity", "."], "h": {"id": "C1333365", "name": "C1333365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["In", "eukaryotes", ",", "pre-rRNA", "processing", "depends", "on", "cis-acting", "elements", "and", "on", "a", "large", "number", "of", "non-ribosomal", "trans-acting", "factors", "including", "endonucleases", "and", "C1333365#ent", "<e1>", ",", "RNA", "helicases", "rRNA", "modifying", "C0014442#ent", "<e2>", "and", "components", "of", "snoRNPs", "."], "h": {"id": "C1333365", "name": "C1333365#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [28, 29]}}
{"token": ["DNA-dependent", "protein", "kinase", "C1528018#ent", "<e1>", ")", "is", "a", "C1333237#ent", "<e2>", "enzyme", "composed", "of", "a", "DNA-binding", "component", "called", "Ku70/80", "and", "a", "catalytic", "subunit", "DNA-PKcs", "."], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [8, 9]}}
{"token": ["Rod", "adaptation", "enhanced", "the", "amplitude", "of", "responses", "of", "C1426584#ent", "<e1>", "to", "rapid", "offset", "without", "C2712370#ent", "<e2>", "response", "time", "course", "."], "h": {"id": "C1426584", "name": "C1426584#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [14, 15]}}
{"token": ["Upper", "airway", "obstruction", "result", "from", "small", "nares", "C0267048#ent", "<e1>", "secondary", "to", "micrognathia", ",", "which", "sometimes", "lead", "to", "C0034072#ent", "<e2>"], "h": {"id": "C0267048", "name": "C0267048#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [17, 18]}}
{"token": ["C1412080#ent", "<e1>", ",", "a", "close", "structural", "homologue", "C3538744#ent", "<e2>", "also", "transported", "PMEA", "."], "h": {"id": "C1412080", "name": "C1412080#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538744", "name": "C3538744#ent", "pos": [7, 8]}}
{"token": ["Results", "show", "a", "predominantly", "apical", "plasma", "membrane", "distribution", "for", "MRP1", "and", "C1412080#ent", "<e1>", ",", "and", "an", "almost", "equal", "distribution", "of", "C3538744#ent", "<e2>", "on", "the", "apical", "and", "basolateral", "plasma", "membrane", "of", "BBMECs", "."], "h": {"id": "C1412080", "name": "C1412080#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538744", "name": "C3538744#ent", "pos": [20, 21]}}
{"token": ["At", "48", "h", "after", "administration", "of", "C0247144#ent", "<e1>", ",", "the", "concentration", "of", "VileX", "exceeds", "that", "of", "the", "C1254351#ent", "<e2>", "many", "tissues", "."], "h": {"id": "C0247144", "name": "C0247144#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [17, 18]}}
{"token": ["C0036391#ent", "<e1>", "results", "from", "mutations", "in", "the", "HSPG2", "gene", "which", "encodes", "C1415793#ent", "<e2>", ",", "a", "major", "component", "of", "basement", "membranes"], "h": {"id": "C0036391", "name": "C0036391#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [11, 12]}}
{"token": ["Heterozygous", "mutations", "two", "patients", "with", "C0036391#ent", "<e1>", "either", "produced", "truncated", "C1415793#ent", "<e2>", "that", "lacked", "domain", "V", "significantly", "reduced", "levels", "of", "wild-type", "C1415793#ent", "<e2>", "."], "h": {"id": "C0036391", "name": "C0036391#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [10, 11]}}
{"token": ["In", "the", "present", "study", ",", "C0026254#ent", "<e1>", "found", "not", "to", "be", "a", "substrate", "for", "partially", "purified", "C1136197#ent", "<e2>", "human", "kidney", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [16, 17]}}
{"token": ["Taken", "together", ",", "these", "results", "indicate", "that", "VEGF", "is", "both", "an", "C1332433#ent", "<e1>", "downstream", "target", "C0017337#ent", "<e2>", "and", "an", "Etk", "upstream", "activator", ",", "constituting", "a", "reciprocal", "Etk-VEGF", "autoregulatory", "loop", "."], "h": {"id": "C1332433", "name": "C1332433#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["Other", "psychotropic", "drugs", "as", "lithium", ",", "valproic", "acid", "buspirone", ",", "carbamazepine", ",", "and", "C0005064#ent", "<e1>", "either", "are", "only", "rarely", "associated", "with", "symptomatic", "C0268528#ent", "<e2>", "or", "do", "not", "produce", "clinically", "important", "changes", "in", "prolactin", "concentrations"], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [22, 23]}}
{"token": ["The", "C1416896#ent", "<e1>", "cDNA", "is", "predicted", "to", "encode", "a", "polypeptide", "of", "94", "C3539947#ent", "<e2>", "with", "a", "molecular", "mass", "about", "10", "kDa", "."], "h": {"id": "C1416896", "name": "C1416896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}}
{"token": ["To", "further", "characterise", "clinical", "characteristics", "of", "giant", "retinal", "tear", "associated", "with", "C0220701#ent", "<e1>", "we", "reviewed", "the", "course", "of", "four", "C0235267#ent", "<e2>", "of", "three", "patients", "."], "h": {"id": "C0220701", "name": "C0220701#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [19, 20]}}
{"token": ["The", "purified", "recombinant", "GST-B23", "being", "phosphorylated", "by", "prometaphase", "cell", "extracts", "nocodazole-arrested", "cells", ")", "or", "C0081947#ent", "<e1>", "still", "be", "co-immunoprecipitated", "with", "C3813550#ent", "<e2>", "."], "h": {"id": "C0081947", "name": "C0081947#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3813550", "name": "C3813550#ent", "pos": [20, 21]}}
{"token": ["With", "the", "recent", "finding", "that", "the", "C1421271#ent", "<e1>", "C3811702#ent", "<e2>", "modifies", "histone", "H2B", "we", "examined", "the", "role", "of", "C3811702#ent", "<e2>", "in", "the", "regulation", "of", "ARG1", "transcription", "."], "h": {"id": "C1421271", "name": "C1421271#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811702", "name": "C3811702#ent", "pos": [8, 9]}}
{"token": ["The", "C1842809#ent", "<e1>", "to", "contain", "all", "coding", "exons", "the", "C1420699#ent", "<e2>", "gene", "linked", "to", "5", "'", "upstream", "regulatory", "sequences", "the", "Alpha", "gene"], "h": {"id": "C1842809", "name": "C1842809#ent", "pos": [1, 2]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1420699", "name": "C1420699#ent", "pos": [9, 10]}}
{"token": ["We", "postulated", "that", "the", "C1842809#ent", "<e1>", "fusion", "may", "result", "in", "deregulated", "expression", "of", "C1420699#ent", "<e2>", "would", "be", "detectable", "by", "IHC", "."], "h": {"id": "C1842809", "name": "C1842809#ent", "pos": [4, 5]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1420699", "name": "C1420699#ent", "pos": [13, 14]}}
{"token": ["As", "the", "genes", "for", "C3815884#ent", "<e1>", "MHC", "alpha", "and", "MHC", "beta", "and", "the", "cardiac", "sarcoplasmic", "reticulum", "Ca2", "C0001473#ent", "<e2>", "SERCA2", ")", "are", "known", "to", "be", "regulated", "by", "T3", ",", "their", "cardiac", "expression", "analyzed", "."], "h": {"id": "C3815884", "name": "C3815884#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [17, 18]}}
{"token": ["The", "mutation", "is", "localized", "near", "a", "functionally", "important", "site", "of", "the", "C3815884#ent", "<e1>", "the", "2", "active", "thiols", ",", "which", "contribute", "to", "the", "C0001473#ent", "<e2>", "activity", "of", "myosin", "S1"], "h": {"id": "C3815884", "name": "C3815884#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "the", "effect", "of", "C2698739#ent", "<e1>", "antagonism", "on", "cocaine-induced", "DA", "overflow", "in", "the", "C1845292#ent", "<e2>", "was", "examined", "and", "correlated", "with", "DA", "neuron", "activity", "in", "the", "ventral", "tegmental", "area", "VTA", ")", "."], "h": {"id": "C2698739", "name": "C2698739#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1845292", "name": "C1845292#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "this", "is", "the", "first", "demonstration", "of", "significant", "elevation", "of", "plasma", "C1707158#ent", "<e1>", "in", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C1707158", "name": "C1707158#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "establish", "the", "relationship", "between", "circulating", "levels", "of", "C1707158#ent", "<e1>", "and", "measures", "of", "left", "ventricular", "size", "systolic", "function", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C1707158", "name": "C1707158#ent", "pos": [15, 16]}, "relation": "gene_associated_with_disease", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [27, 28]}}
{"token": ["A", "female", "baby", "sustained", "C0032319#ent", "<e1>", "after", "bronchoscopic", "CO2", "laser", "surgery", "for", "C0040583#ent", "<e2>"], "h": {"id": "C0032319", "name": "C0032319#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040583", "name": "C0040583#ent", "pos": [12, 13]}}
{"token": ["Increased", "C0694888#ent", "<e1>", "expression", "in", "unstimulated", "MCF-7", "breast", "cancer", "cells", "results", "in", "a", "51", "%", "increase", "in", "C0031607#ent", "<e2>", "with", "a", "decrease", "in", "phosphatidylcholine", ",", "suggesting", "that", "C0694888#ent", "<e1>", "may", "regulate", "phospholipase", "D", "PLD", ")", "."], "h": {"id": "C0031607", "name": "C0031607#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0694888", "name": "C0694888#ent", "pos": [1, 2]}}
{"token": ["Injection", "of", "an", "C3536824#ent", "<e1>", "AP-5", ",", "into", "the", "Vi/Vc", "and", "C0024544#ent", "<e2>", "attenuated", "masseter", "inflammatory", "hyperalgesia", "."], "h": {"id": "C3536824", "name": "C3536824#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [11, 12]}}
{"token": ["At", "high-medium", "cholesterol", ",", "there", "was", "a", "large", "cholesterol-induced", "increase", "in", "C1258847#ent", "<e1>", "activity", "that", "obscured", "most", "of", "the", "effect", "of", "C0011777#ent", "<e2>", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [21, 22]}}
{"token": ["C1705341#ent", "<e1>", "and", "Src", "were", "phosphorylated", "more", "on", "C0002893#ent", "<e2>", "versus", "OA", "and", "ND", "lining", "cells", "and", "MPhis", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002893", "name": "C0002893#ent", "pos": [8, 9]}}
{"token": ["C1705341#ent", "<e1>", "was", "expressed", "on", "C0002893#ent", "<e2>", "ST", "fibrobasts", "but", "not", "in", "MPhis", "at", "baseline", ",", "however", "it", "was", "upregulated", "upon", "TNFalpha", "or", "IL1beta", "activation", "in", "both", "cell", "types"], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002893", "name": "C0002893#ent", "pos": [5, 6]}}
{"token": ["All", "three", "C0080058#ent", "<e1>", "K-", ",", "N-", "and", "H-Ras", ",", "interact", "with", "C0376515#ent", "<e2>", ";", "however", ",", "their", "mitochondrial", "localization", "differentially", "regulated", "in", "IL-2-supplemented", "or", "-deprived", "cells", "."], "h": {"id": "C0080058", "name": "C0080058#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [12, 13]}}
{"token": ["Wolman's", "disease", "fibroblasts", ",", "which", "are", "deficient", "in", "C0544512#ent", "<e1>", "effectively", "hydrolyzed", "CE", "from", "C3715113#ent", "<e2>", ",", "but", "not", "CE", "taken", "up", "in", "low", "density", "lipoproteins", "LDL", ")", ";", "normal", "fibroblasts", "hydrolyzed", "both", "effectively", "."], "h": {"id": "C0544512", "name": "C0544512#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3715113", "name": "C3715113#ent", "pos": [14, 15]}}
{"token": ["In", "others", ",", "concurrent", "administration", "of", "an", "C0019593#ent", "<e1>", "required", "to", "reduce", "gastric", "acidity", "prevent", "C0014442#ent", "<e2>", "inactivation", "in", "the", "stomach", "."], "h": {"id": "C0019593", "name": "C0019593#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "the", "H1", "antagonist", "chlorpheniramine", "C0019593#ent", "<e1>", "dimaprit", "caused", "reductions", "in", "flow", "and", "C0014442#ent", "<e2>", "output", "."], "h": {"id": "C0019593", "name": "C0019593#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["Because", "of", "cocaine", "'s", "ability", "to", "block", "cardiac", "sodium", "channels", "sodium", "bicarbonate", "C0074722#ent", "<e1>", ")", "has", "been", "proposed", "as", "an", "C3536843#ent", "<e2>", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3536843", "name": "C3536843#ent", "pos": [20, 21]}}
{"token": ["These", "pains", "included", "headache", ",", "backache", ",", "C0030193#ent", "<e1>", "the", "limbs", ",", "and", "C0008035#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0008035", "name": "C0008035#ent", "pos": [13, 14]}}
{"token": ["Atopic", "HNEC", "showed", "further", "up-regulation", "in", "C1706544#ent", "<e1>", "expression", "when", "cultured", "with", "clinically", "relevant", "C3274161#ent", "<e2>", "(", "P", "=", "0.032", ")", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [14, 15]}}
{"token": ["This", "elevated", "nasal", "polyp", "C1706544#ent", "<e1>", "level", "was", "not", "increased", "further", "by", "C3274161#ent", "<e2>", ",", "although", "HRV", "infection", "resulted", "in", "a", "small", "significant", "increase", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [12, 13]}}
{"token": ["Here", ",", "we", "report", "that", "C0667830#ent", "<e1>", "3", "activation", ",", "poly(ADP-ribose)polymerase", "cleavage", "apoptosis", "are", "inhibited", "by", "the", "C1289971#ent", "<e2>", "nordihydroguaretic", "acid", "NDGA", ")", ",", "or", "ectopic", "expression", "of", "crm-A", "or", "bcl-2", "."], "h": {"id": "C0667830", "name": "C0667830#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1289971", "name": "C1289971#ent", "pos": [17, 18]}}
{"token": ["Because", "beta-adrenergic", "blocking", "agents", "including", "the", "cardioselective", "drugs", ",", "have", "been", "known", "to", "exacerbate", "COPD", ",", "C0018312#ent", "<e1>", "treatment", "may", "be", "preferable", "as", "C0003364#ent", "<e2>", "patients", "with", "asthma", "and", "other", "forms", "of", "COPD", "."], "h": {"id": "C0018312", "name": "C0018312#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [23, 24]}}
{"token": ["In", "vitro", "with", "human", "liver", "microsomes", "have", "suggested", "that", "major", "oxidation", "pathways", "C0543459#ent", "<e1>", "are", "predominantly", "catalyzed", "by", "the", "genetically", "determined", "C3887685#ent", "<e2>", "cytochrome", "P450IID6)", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [12, 13]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [21, 22]}}
{"token": ["C0543459#ent", "<e1>", "has", "been", "reported", "to", "be", "hydroxylated", "by", "cytochrome", "P450", "2D6", "C3887685#ent", "<e2>", ")", "in", "humans", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [12, 13]}}
{"token": ["These", "results", "are", "in", "strong", "agreement", "with", "a", "biosynthetic", "relationship", "between", "C1413682#ent", "<e1>", ",", "AVP", "and", "C1706109#ent", "<e2>", ",", "and", "their", "separateness", "from", "the", "OXY", "and", "OXY-NP", "precursor", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706109", "name": "C1706109#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "PGE1", "inhibited", "the", "increase", "in", "C1413682#ent", "<e1>", "induced", "by", "LTD4", "and", "arginine", "vasopressin", "C1706109#ent", "<e2>", ")", "in", "the", "isolated", "perfused", "rat", "heart", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706109", "name": "C1706109#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "the", "concentration", "of", "alpha-", "and", "C0887942#ent", "<e1>", "in", "gastric", "juice", "patients", "with", "various", "C0013289#ent", "<e2>"], "h": {"id": "C0887942", "name": "C0887942#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013289", "name": "C0013289#ent", "pos": [15, 16]}}
{"token": ["In", "eight", "isolated", "dog", "lobes", ",", "we", "examined", "the", "change", "in", "extra-alveolar", "perimicrovascular", "hydrostatic", "pressure", "(", "C1413284#ent", "<e1>", ")", "due", "to", "C1167782#ent", "<e2>"], "h": {"id": "C1413284", "name": "C1413284#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1167782", "name": "C1167782#ent", "pos": [21, 22]}}
{"token": ["Mycoplasma", "pneumoniae", "infection", "associated", "with", "manifestations", "from", "the", "central", "nervous", "system", "CNS", ")", "such", "as", "C0014060#ent", "<e1>", ",", "aseptic", "meningitis", "acute", "transverse", "myelitis", "stroke", ",", "and", "C0032586#ent", "<e2>", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032586", "name": "C0032586#ent", "pos": [26, 27]}}
{"token": ["Automodification", "of", "the", "C3888277#ent", "<e1>", "decreased", "polyanion-induced", "ADP-ribosylation", "of", "C1334129#ent", "<e2>", "."], "h": {"id": "C3888277", "name": "C3888277#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334129", "name": "C1334129#ent", "pos": [9, 10]}}
{"token": ["The", "overall", "C0018081#ent", "<e1>", "sensitive", "to", "ceftriaxone", ",", "C0008809#ent", "<e2>", ",", "spectinomycin", "and", "azithromycin", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [8, 9]}}
{"token": ["We", "now", "recommend", "treating", "uncomplicated", "C0018081#ent", "<e1>", "a", "single", "oral", "dose", "C0008809#ent", "<e2>", "500", "mg", ",", "or", "ofloxacin", "400", "mg", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [11, 12]}}
{"token": ["We", "have", "explored", "the", "relationship", "between", "Axin", "and", "Dvl-2", ",", "a", "member", "of", "the", "C1414199#ent", "<e1>", "proteins", "that", "function", "upstream", "of", "C0244988#ent", "<e2>", "."], "h": {"id": "C1414199", "name": "C1414199#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [21, 22]}}
{"token": ["C0026454#ent", "<e1>", "inhibition", "may", "be", "more", "important", "than", "C0026457#ent", "<e2>", "antidepressant", "efficacy", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026457", "name": "C0026457#ent", "pos": [8, 9]}}
{"token": ["Moclobemide", "was", "not", "effective", "even", "when", "the", "C0026454#ent", "<e1>", "enzymes", "were", "additionally", "blocked", "by", "the", "C0026457#ent", "<e2>", "deprenyl", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026457", "name": "C0026457#ent", "pos": [15, 16]}}
{"token": ["administration", "of", "C0026454#ent", "<e1>", "in", "mice", "pretreated", "with", "safrazine", ",", "a", "C0026457#ent", "<e2>"], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026457", "name": "C0026457#ent", "pos": [11, 12]}}
{"token": ["It", "may", "be", "the", "only", "manifestation", "of", "the", "disease", "in", "the", "sense", "of", "C0003864#ent", "<e1>", "or", "one", "of", "few", "affected", "sites", "as", "in", "C3892044#ent", "<e2>", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C3892044", "name": "C3892044#ent", "pos": [23, 24]}}
{"token": ["We", "therefore", "examined", "this", "question", "in", "the", "COPERNICUS", "study", "of", "2289", "patients", "with", "severe", "C0018802#ent", "<e1>", "receiving", "the", "beta1-beta2/alpha1", "blocker", "C0054836#ent", "<e2>", "compared", "with", "placebo", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0054836", "name": "C0054836#ent", "pos": [20, 21]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "determine", "if", "these", "antioxidant", "effects", "detectable", "in", "patients", "with", "C0018802#ent", "<e1>", "to", "compare", "C0054836#ent", "<e2>", "with", "the", "selective", "beta-blocker", "metoprolol"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0054836", "name": "C0054836#ent", "pos": [20, 21]}}
{"token": ["Endoscopy", "excluded", "C0022354#ent", "<e1>", "but", "a", "suspicion", "of", "C1290884#ent", "<e2>", "possibly", "cirrhosis", "was", "raised", "in", "the", "differential", "diagnosis"], "h": {"id": "C0022354", "name": "C0022354#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [8, 9]}}
{"token": ["The", "myelodysplastic", "syndromes", "C3273937#ent", "<e1>", ")", "are", "a", "C0012634#ent", "<e2>", "are", "characterized", "by", "ineffective", "hematopoiesis", "and", "evolution", "to", "acute", "myelogenous", "leukemias", "AMLs", ")", "that", "are", "strikingly", "refractory", "to", "current", "therapeutic", "approaches"], "h": {"id": "C3273937", "name": "C3273937#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}}
{"token": ["Myelodysplastic", "syndromes", "C3273937#ent", "<e1>", ")", "are", "characterized", "by", "a", "C0012634#ent", "<e2>", "haemopoiesis", "with", "defective", "growth", "in", "vitro"], "h": {"id": "C3273937", "name": "C3273937#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}}
{"token": ["Myelodysplastic", "syndromes", "C3273937#ent", "<e1>", ")", "are", "a", "heterogeneous", "group", "C0012634#ent", "<e2>", "characterized", "by", "a", "cytopenia", "related", "to", "abnormal", "proliferation", "and", "differentiation", "of", "marrow", "precursor", "cells"], "h": {"id": "C3273937", "name": "C3273937#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}}
{"token": ["To", "identify", "the", "PSF1-binding", "protein", ",", "we", "used", "the", "yeast", "two-hybrid", "system", "C1825347#ent", "<e1>", "as", "bait", ",", "and", "identified", "and", "cloned", "C1825350#ent", "<e2>", "."], "h": {"id": "C1825347", "name": "C1825347#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1825350", "name": "C1825350#ent", "pos": [21, 22]}}
{"token": ["C3542501#ent", "<e1>", "CIDP", ")", "is", "an", "uncommon", "C0011302#ent", "<e2>", "a", "relapsing", "and", "remitting", "or", "continuously", "progressive", "course", "."], "h": {"id": "C3542501", "name": "C3542501#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011302", "name": "C0011302#ent", "pos": [7, 8]}}
{"token": ["It", "is", "unclear", "whether", "sporadic", "reports", "concurrent", "multiple", "sclerosis", "MS", ")", "and", "C3542501#ent", "<e1>", "CIDP", ")", "represent", "coincidence", "or", "whether", "these", "two", "C0011302#ent", "<e2>", "pathogenically", "related", "."], "h": {"id": "C3542501", "name": "C3542501#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011302", "name": "C0011302#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "chromatin", "immunoprecipitation", "assays", "that", "ectopically", "expressed", "COUP-TFI", ",", "Ubc9", ",", "and", "C1413968#ent", "<e1>", "were", "recruited", "to", "an", "endogenous", "C1413857#ent", "<e2>", "promoter", "."], "h": {"id": "C1413968", "name": "C1413968#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413857", "name": "C1413857#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "reduction", "of", "Ubc9", "or", "C1413968#ent", "<e1>", "protein", "levels", "by", "small", "interfering", "RNA", "inhibited", "the", "C1413857#ent", "<e2>", "COUP-TFI", "."], "h": {"id": "C1413968", "name": "C1413968#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413857", "name": "C1413857#ent", "pos": [16, 17]}}
{"token": ["The", "stimulatory", "effect", "was", "abolished", "by", "the", "C0089795#ent", "<e1>", "PLC", ")", "blocker", "U-73122", ",", "by", "the", "selective", "protein", "kinase", "C", "C1826724#ent", "<e2>", ")", "blocker", "chelerythrine", "and", "by", "the", "calcium-channels", "blockers", "Ni++", "Co++", "and", "Cd++", "."], "h": {"id": "C0089795", "name": "C0089795#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [20, 21]}}
{"token": ["Alternative", "splicing", "resulting", "in", "the", "short", "precursor", "which", "GRF-32", "is", "excised", ",", "may", "provide", "a", "means", "for", "differential", "control", "C3539616#ent", "<e1>", "secretion", "with", "higher", "production", "of", "the", "more", "potent", "C1412228#ent", "<e2>", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [29, 30]}}
{"token": ["The", "cAMP", "antagonist", "was", "unable", "to", "block", "the", "C3539616#ent", "<e1>", "response", "to", "C1412228#ent", "<e2>", "suggesting", "that", "cAMP", "does", "not", "mediate", "the", "secretory", "response", "this", "peptide", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "heterozygous", "C2939465#ent", "<e1>", "associated", "with", "reduced", "risk", "of", "C0002871#ent", "<e2>", "among", "infected", "multigravidae", "(", "OR", ",", "0.5", "[", "0.3", "-", "1.0", "]", ")", "."], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [11, 12]}}
{"token": ["C0238402#ent", "<e1>", "is", "an", "uncommon", "form", "of", "C0029464#ent", "<e2>", "bone", "disease"], "h": {"id": "C0238402", "name": "C0238402#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0029464", "name": "C0029464#ent", "pos": [7, 8]}}
{"token": ["Both", "GlcAT-P", "and", "C1259497#ent", "<e1>", "transferred", "glucuronic", "acid", "GlcA", ")", "not", "only", "to", "a", "glycoprotein", "acceptor", "C0052499#ent", "<e2>", "(", "ASOR", ")", ",", "but", "also", "to", "a", "glycolipid", "acceptor", "paragloboside", "."], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0052499", "name": "C0052499#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "treatment", "of", "mice", "(", "db/db", "or", "fat-fed", ")", "with", "C0025598#ent", "<e1>", "or", "a", "PPARalpha", "C2987634#ent", "<e2>", "did", "not", "affect", "plasma", "Acrp30", "protein", "."], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [17, 18]}}
{"token": ["It", "is", "suggested", "that", "C0025598#ent", "<e1>", "acts", "as", "a", "weak", "histamine", "C2987634#ent", "<e2>", "."], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}}
{"token": ["This", "effect", "is", "upstream", "of", "C1826724#ent", "<e1>", "activation", ",", "because", "neither", "Syt", "IVQ", "nor", "C3273633#ent", "<e2>", "blocked", "the", "effects", "of", "phorbol", "esters", "reversing", "synaptic", "depression", "the", "effects", "of", "serotonin", "on", "facilitating", "nondepressed", "synapses", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273633", "name": "C3273633#ent", "pos": [14, 15]}}
{"token": ["We", "highlight", "the", "importance", "of", "considering", "the", "diagnosis", "of", "AOA1", "in", "children", "with", "early-onset", "C0007758#ent", "<e1>", "once", "other", "well-known", "disorders", "such", "as", "Friedreich's", "ataxia", "C0004135#ent", "<e2>", "have", "been", "excluded", "."], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [24, 25]}}
{"token": ["Previous", "studies", "have", "demonstrated", "that", "mutation", "in", "C0243769#ent", "<e1>", "Cys313", "or", "Cys540", "to", "Ser", "residues", "cyclooxygenase", "and", "C0027021#ent", "<e2>", "activities", "by", "80", "-", "90", "%", "."], "h": {"id": "C0243769", "name": "C0243769#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [17, 18]}}
{"token": ["Purification", "and", "assay", "of", "14", "C1564139#ent", "<e1>", "correlation", "between", "their", "C0012892#ent", "<e2>", "in", "vitro", "ability", "to", "complement", "the", "Pol", "Its", "phenotype", "."], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [10, 11]}}
{"token": ["Together", ",", "these", "data", "suggest", "that", "smad1", "acts", "later", "than", "C1416963#ent", "<e1>", "and", "is", "itself", "a", "transcriptional", "target", "of", "Smad5-mediated", "C2986866#ent", "<e2>", "signaling", "."], "h": {"id": "C1416963", "name": "C1416963#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2986866", "name": "C2986866#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "the", "effects", "of", "exogenously", "administered", "corticosterone", "and", "the", "MR", "antagonist", "C0037982#ent", "<e1>", "were", "examined", "at", "times", "of", "different", "C4048158#ent", "<e2>", "susceptibility", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [21, 22]}}
{"token": ["While", "non-transgenic", "mice", "the", "expected", "clustering", "of", "mutations", "in", "C0263214#ent", "<e1>", "mutations", "from", "C1704467#ent", "<e2>", "transgenic", "mice", "this", "pattern", "."], "h": {"id": "C0263214", "name": "C0263214#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [13, 14]}}
{"token": ["Four", "of", "identified", "proteins", ":", "cystein", "and", "glycine-rich", "protein", "1", ",", "C1414295#ent", "<e1>", "U5", "snRNP-specific", "protein", "116", "kD", ",", "and", "C1420121#ent", "<e2>", "are", "involved", "in", "actin", "cytoskeleton", "organization", ",", "cell", "adhesion", "translation", "and", "transcriptional", "regulation"], "h": {"id": "C1414295", "name": "C1414295#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420121", "name": "C1420121#ent", "pos": [20, 21]}}
{"token": ["Afew", "others", "like", "C0268784#ent", "<e1>", "cholesterol", "embolism", "Clq", "nephropathy", ",", "oxalosis", ",", "mixed", "connective", "tissue", "disorder", "C0026272#ent", "<e2>", ",", "Wegner's", "granulomatosis", "."], "h": {"id": "C0268784", "name": "C0268784#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026272", "name": "C0026272#ent", "pos": [16, 17]}}
{"token": ["The", "C1822723#ent", "<e1>", "results", "showed", "that", "the", "C0723176#ent", "<e2>", "retention", "behavior", "compounds", "using", "carbon", "dioxide-methanol", "with", "polar", "stationary", "phases", "close", "to", "that", "reported", "for", "normal", "phase", "LC", "using", "hexane-methanol", "."], "h": {"id": "C1822723", "name": "C1822723#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0723176", "name": "C0723176#ent", "pos": [7, 8]}}
{"token": ["Hyperkalemic", "responses", "both", "physical", "exercise", "C0001640#ent", "<e1>", "enhanced", "in", "patients", "with", "C3854173#ent", "<e2>"], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [11, 12]}}
{"token": ["Incubation", "of", "platelets", "with", "antimycin", "before", "C1414504#ent", "<e1>", "addition", "increased", "the", "rate", "of", "fall", "in", "metabolic", "C2744579#ent", "<e2>", ",", "but", "did", "not", "affect", "the", "rate", "of", "adenine", "nucleotide", "secretion"], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [16, 17]}}
{"token": ["Tyrosine", "hydroxylase", "TH", ")", ",", "the", "rate-limiting", "enzyme", "in", "catecholamine", "synthesis", ",", "is", "stimulated", "by", "N-terminal", "phosphorylation", "several", "C0031727#ent", "<e1>", "and", "inhibited", "by", "C0084210#ent", "<e2>", "PP2A", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0084210", "name": "C0084210#ent", "pos": [23, 24]}}
{"token": ["Purified", "extracellular", "regulated", "C0031727#ent", "<e1>", "blocked", "casein", "kinase", "2", "activity", "increased", "C0084210#ent", "<e2>", "activity", ",", "resulting", "in", "an", "increased", "Sp1", "binding", "and", "endothelial", "nitric-oxide", "synthase", "promoter", "activity"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0084210", "name": "C0084210#ent", "pos": [11, 12]}}
{"token": ["We", "also", "found", "that", "expression", "levels", "of", "CDK", "activation", "kinase", "CDC25C", "were", "reduced", ",", "and", "C2828924#ent", "<e1>", "inactive", "form", "C1332733#ent", "<e2>", "were", "up-regulated", "."], "h": {"id": "C2828924", "name": "C2828924#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332733", "name": "C1332733#ent", "pos": [19, 20]}}
{"token": ["The", "autophosphorylation", "reaction", "analysed", "using", "C1564140#ent", "<e1>", "defective", "in", "C0031727#ent", "<e2>", "and", "regulatory", "functions"], "h": {"id": "C1564140", "name": "C1564140#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}}
{"token": ["These", "results", "are", "correlated", "with", "the", "crystal", "structure", "models", "of", "the", "respective", "C1564140#ent", "<e1>", "and", "conservation", "of", "the", "Glys", "within", "the", "C0031727#ent", "<e2>"], "h": {"id": "C1564140", "name": "C1564140#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["Receptors", "that", "couple", "to", "pertussis", "toxin", "C0086376#ent", "<e1>", "evoke", "large", "increases", "in", "C2987154#ent", "<e2>", "activity", "and", "intracellular", "Ca2", "+", "release", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [12, 13]}}
{"token": ["A", "new", "class", "of", "C0086376#ent", "<e1>", "Gh", ")", "couples", "to", "a", "69-kDa", "phospholipase", "C", "(", "C2987154#ent", "<e2>", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [15, 16]}}
{"token": ["Heterotrimeric", "guanine", "nucleotide-binding", "regulatory", "proteins", "C0086376#ent", "<e1>", "of", "the", "Gq", "subfamily", "activate", "the", "PLC", "beta", "1", "isoform", "of", "C2987154#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [18, 19]}}
{"token": ["Receptors", "coupled", "to", "heterotrimeric", "guanine", "nucleotide-binding", "proteins", "C0086376#ent", "<e1>", "activate", "phosphatidylinositol", "4,5-bisphosphate", "PtdIns(4,5)P2)-hydrolyzing", "phospholipase", "C", "(", "C2987154#ent", "<e2>", ")", "enzymes", "by", "activated", "alpha", "of", "free", "beta", "gamma", "subunits", "of", "the", "relevant", "C0086376#ent", "<e1>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [16, 17]}}
{"token": ["We", "concluded", "the", "oral", "calcium", "antagonist", "C0012373#ent", "<e1>", ",", "is", "effective", "in", "patients", "with", "C0155583#ent", "<e2>", "providing", "significant", "blood", "pressure", "and", "symptomatic", "benefit", "with", "long-term", "treatment", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [14, 15]}}
{"token": ["This", "trial", "was", "performed", "to", "determine", "the", "safe", "and", "effective", "dosage", "range", "of", "once", "daily", "diltiazem", "(", "C0012373#ent", "<e1>", "capsules", "for", "treatment", "of", "C0155583#ent", "<e2>"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [23, 24]}}
{"token": ["Imidazole", "inhibited", "the", "C0002586#ent", "<e1>", "while", "imidazole", ",", "C0034665#ent", "<e2>", ",", "and", "ICI", "125,211", "inhibited", "the", "caffeine", "breath", "in", "vivo"], "h": {"id": "C0002586", "name": "C0002586#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [8, 9]}}
{"token": ["Cimetidine", "(", "40", "mg/kg", ")", "decreased", "the", "C0002586#ent", "<e1>", "metabolic", "clearance", "by", "73", "p.", "100", ",", "whereas", "C0034665#ent", "<e2>", "caused", "no", "change"], "h": {"id": "C0002586", "name": "C0002586#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [17, 18]}}
{"token": ["In", "a", "prospective", ",", "randomized", ",", "double-masked", "study", "44", "patients", "with", "C0017612#ent", "<e1>", "treated", "either", "with", "0.5", "%", "C0543470#ent", "<e2>", "or", "0.5", "%", "timolol", "in", "both", "eyes", "twice", "daily", "."], "h": {"id": "C0017612", "name": "C0017612#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0543470", "name": "C0543470#ent", "pos": [18, 19]}}
{"token": ["The", "results", "of", "the", "study", "indicate", "that", "rasagiline", "confers", "neuroprotection", "in", "a", "transgenic", "mouse", "model", "of", "C0000294#ent", "<e1>", "and", "may", "therefore", "be", "considered", "a", "promising", "C1433596#ent", "<e2>", "candidate", "for", "human", "C0000294#ent", "<e1>", "."], "h": {"id": "C0000294", "name": "C0000294#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1433596", "name": "C1433596#ent", "pos": [25, 26]}}
{"token": ["RNA", "blot", "C0597094#ent", "<e1>", "and", "primer", "extension", "analysis", "that", "the", "C0022245#ent", "<e2>", "inducible", "parotid", "gland", "mRNAs", "do", "not", "contain", "the", "kinase", "domain", "but", "represent", "part", "of", "the", "C-terminal", "segment", "the", "abl", "reading", "frame"], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [10, 11]}}
{"token": ["Coadministration", "of", "the", "toxic", "subunit", "CTA", ",", "together", "with", "C1418397#ent", "<e1>", "and", "OVA", "Ag", ",", "led", "to", "enhanced", "C1423842#ent", "<e2>", "and", "Th2", "responses", "."], "h": {"id": "C1418397", "name": "C1418397#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [18, 19]}}
{"token": ["Thus", "C0013295#ent", "<e1>", "patients", "with", "C0752235#ent", "<e2>", "a", "separate", "enity", "within", "the", "context", "of", "stress", "lesions"], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [5, 6]}}
{"token": ["To", "explore", "the", "effect", "of", "gamma-aminobutyric", "acid", "B", "receptor", "GABA(B)R)on", "nitric", "oxide", "(NO)/nitric", "C0907533#ent", "<e1>", "NOS", ")", "system", "during", "recurrent", "C0009952#ent", "<e2>", "FS", ")", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [20, 21]}}
{"token": ["Compounds", "containing", "an", "acetic", "acid", "18", ")", "or", "a", "propionic", "acid", "residue", "20", ")", "at", "the", "5-position", "of", "the", "C0020923#ent", "<e1>", "were", "more", "potent", "than", "the", "C1517282#ent", "<e2>", "24", ")", "."], "h": {"id": "C0020923", "name": "C0020923#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1517282", "name": "C1517282#ent", "pos": [26, 27]}}
{"token": ["NO", "quenched", "the", "C1366515#ent", "<e1>", "signal", "generated", "by", "reaction", "of", "purified", "ram", "seminal", "vesicle", "C1335271#ent", "<e2>", "with", "arachidonic", "acid", "suggesting", "that", "NO", "coupled", "with", "a", "tyrosyl", "radical", "to", "form", "inter", "alia", "nitrosocyclohexadienone", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335271", "name": "C1335271#ent", "pos": [14, 15]}}
{"token": ["C0062637#ent", "<e1>", "completely", "inhibited", "both", "C0017547#ent", "<e2>", "migrating", "contractions", "and", "phasic", "contractions", "."], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [5, 6]}}
{"token": ["We", "used", "the", "biased", "C2917660#ent", "<e1>", "composition", "of", "C1412284#ent", "<e2>", "to", "identify", "C1412284#ent", "<e2>", "and", "arabinogalactan", "(", "AG", ")", "peptides", "in", "the", "Arabidopsis", "genome", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412284", "name": "C1412284#ent", "pos": [8, 9]}}
{"token": ["C0053653#ent", "<e1>", "was", "applied", "to", "the", "C0032002#ent", "<e2>", "attached", "to", "the", "brain", "in", "vitro"], "h": {"id": "C0053653", "name": "C0053653#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [6, 7]}}
{"token": ["C0006444#ent", "<e1>", "should", "therefore", "be", "considered", "in", "the", "differential", "diagnoses", "C0015467#ent", "<e2>", "temporomandibular", "joint", "dysfunction", "and", "myofascial", "pain", "dysfunction", "syndrome"], "h": {"id": "C0006444", "name": "C0006444#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015467", "name": "C0015467#ent", "pos": [10, 11]}}
{"token": ["C0935942#ent", "<e1>", "(", "MK-0991", ";", "L-743,872", ")", "belongs", "to", "the", "C1268551#ent", "<e2>", "a", "new", "class", "of", "antifungal", "agents", "act", "on", "the", "fungal", "cell", "wall", "inhibiting", "glucan", "synthesis", "."], "h": {"id": "C0935942", "name": "C0935942#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C1268551", "name": "C1268551#ent", "pos": [10, 11]}}
{"token": ["The", "overall", "incidence", "of", "C0085083#ent", "<e1>", "2.4", "%", "in", "the", "C0073629#ent", "<e2>", "group", "and", "5.9", "%", "in", "the", "reference", "group"], "h": {"id": "C0085083", "name": "C0085083#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0073629", "name": "C0073629#ent", "pos": [10, 11]}}
{"token": ["Mutagenesis", "of", "three", "basic", "residues", "(", "lysine-99", ",", "arginine-100", ",", "and", "arginine-102", ")", "resulted", "in", "a", "C0034861#ent", "<e1>", "APPhep", ")", "with", "decreased", "C1332127#ent", "<e2>"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332127", "name": "C1332127#ent", "pos": [22, 23]}}
{"token": ["In", "conclusion", ",", "our", "data", "show", "that", "this", "C0034861#ent", "<e1>", "the", "native", "protein", "appears", "to", "have", "similar", "immunologic", ",", "C1332127#ent", "<e2>", ",", "and", "chemotactic", "properties", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332127", "name": "C1332127#ent", "pos": [19, 20]}}
{"token": ["In", "the", "class", "of", "topical", "NSAIDs", ",", "ketorolac", "has", "been", "promoted", "for", "ocular", "itching", "has", "been", "found", "to", "be", "inferior", "for", "relief", "of", "C0009766#ent", "<e1>", "compared", "with", "C0527189#ent", "<e2>", "and", "emedastine", "."], "h": {"id": "C0009766", "name": "C0009766#ent", "pos": [23, 24]}, "relation": "may_be_treated_by", "t": {"id": "C0527189", "name": "C0527189#ent", "pos": [27, 28]}}
{"token": ["Besides", "the", "classic", "venereal", "diseases", "candidiasis", ",", "C0040921#ent", "<e1>", ",", "hemophilus", "and", "herpes", "infections", "and", "also", "C0009663#ent", "<e2>", "found", "very", "frequently", "in", "the", "female", "population", "."], "h": {"id": "C0040921", "name": "C0040921#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009663", "name": "C0009663#ent", "pos": [16, 17]}}
{"token": ["Pretreatment", "of", "the", "cultures", "with", "AG", "490", ",", "a", "specific", "C3854326#ent", "<e1>", "and", "with", "SB", "203580", ",", "a", "C0752312#ent", "<e2>", "MAP", "kinase", "inhibitor", ",", "abolished", "the", "increase", "in", "[Ca2+]i", "evoked", "by", "leptin", "."], "h": {"id": "C3854326", "name": "C3854326#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [18, 19]}}
{"token": ["Pretreatment", "of", "the", "cultures", "with", "AG", "490", ",", "a", "specific", "C3854326#ent", "<e1>", "and", "with", "SB", "203580", ",", "a", "mitogen-activated", "protein", "kinase", "C0752312#ent", "<e2>", "inhibitor", ",", "abolished", "the", "increase", "in", "[Ca2+]i", "evoked", "by", "leptin", "."], "h": {"id": "C3854326", "name": "C3854326#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [21, 22]}}
{"token": ["It", "also", "downregulated", "the", "phosphorylation", "of", "extracellular", ",", "signal-regulated", "protein", "kinase", "p38", "mitogen-activated", "protein", "kinase", "are", "upstream", "of", "NF-kappa", "B.", ",", "DA-9601", "reduced", "expression", "of", "C1332803#ent", "<e1>", "in", "colonic", "mucosa", "mice", "challenged", "with", "AOM", "plus", "C0011195#ent", "<e2>", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0011195", "name": "C0011195#ent", "pos": [35, 36]}}
{"token": ["Clinically", ",", "C0342288#ent", "<e1>", "manifests", "most", "commonly", "with", "diarrhea", ",", "insulin-dependent", "diabetes", "mellitus", "thyroid", "disorders", "and", "C0013595#ent", "<e2>", "."], "h": {"id": "C0342288", "name": "C0342288#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [16, 17]}}
{"token": ["The", "results", "indicate", "that", "5-HT3", "recognition", "sites", "are", "present", "within", "the", "area", "postrema", "may", "afford", "an", "C0003297#ent", "<e1>", "action", "for", "C0078743#ent", "<e2>", "and", "other", "5-HT3", "receptor", "antagonists"], "h": {"id": "C0003297", "name": "C0003297#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0078743", "name": "C0078743#ent", "pos": [20, 21]}}
{"token": ["The", "new", "C0003297#ent", "<e1>", "and", "gastrokinetic", "agent", "C0078743#ent", "<e2>", "was", "tested", "in", "rhesus", "monkeys", "assess", "its", "behavioral", "toxicity", "and", "its", "ability", "to", "inhibit", "radiation-induced", "emesis"], "h": {"id": "C0003297", "name": "C0003297#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0078743", "name": "C0078743#ent", "pos": [7, 8]}}
{"token": ["C0043941#ent", "<e1>", ",", "mannitol", "or", "combination", "of", "C1704945#ent", "<e2>", "and", "C0043941#ent", "<e1>", "markedly", "reduced", "the", "Ach-induced", "relaxation", "."], "h": {"id": "C0043941", "name": "C0043941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [7, 8]}}
{"token": ["The", "activity", "of", "SOD", ",", "GSH-Px", ",", "CAT", ",", "concentrations", "of", "erythrocyte", "and", "plasma", "C1414863#ent", "<e1>", ",", "Cu", ",", "Zn", "were", "lower", "in", "children", "with", "C0035078#ent", "<e2>", "than", "in", "controls", "."], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [25, 26]}}
{"token": ["C1425478#ent", "<e1>", "translocation", "into", "the", "nucleus", "was", "attributable", "to", "elevated", "tumor", "necrosis", "factor-alpha", "C1710304#ent", "<e2>", ")", "protein", "."], "h": {"id": "C1425478", "name": "C1425478#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [13, 14]}}
{"token": ["The", "possibility", "that", "C0240066#ent", "<e1>", "induce", "the", "breakdown", "of", "the", "blood-brain", "barrier", "C1801950#ent", "<e2>", ")", "was", "examined", "."], "h": {"id": "C0240066", "name": "C0240066#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1801950", "name": "C1801950#ent", "pos": [12, 13]}}
{"token": ["The", "management", "of", "C0014544#ent", "<e1>", "incurs", "significant", "costs", "to", "the", "United", "Kingdom", "UK", ")", "National", "Health", "Service", "C1417725#ent", "<e2>", ")", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417725", "name": "C1417725#ent", "pos": [17, 18]}}
{"token": ["Each", "of", "the", "freely", "available", "local", "analgesic", "agents", "be", "used", ",", "alone", "or", "in", "combination", ",", "with", "or", "without", "C0020197#ent", "<e1>", ",", "epinephrine", "and", "sodium", "bicarbonate", "peribulbar", "block", "analgesia", "(", "C0281398#ent", "<e2>", ")", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0281398", "name": "C0281398#ent", "pos": [30, 31]}}
{"token": ["Only", "C0013604#ent", "<e1>", "was", "observed", "in", "animals", "treated", "with", "C0042523#ent", "<e2>", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [9, 10]}}
{"token": ["The", "choice", "of", "antihypertensive", "agent", "be", "limited", "by", "adverse", "effects", "e.g.", "C0013604#ent", "<e1>", "nifedipine", ",", "constipation", "with", "C0042523#ent", "<e2>", ",", "and", "cough", "with", "ACE", "inhibitors"], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [17, 18]}}
{"token": ["We", "investigated", "whether", "this", "initial", "damage", "is", "followed", "by", "the", "development", "of", "C0018801#ent", "<e1>", "assessed", "the", "particular", "role", "of", "the", "renin-angiotensin", "system", "C0072973#ent", "<e2>", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0072973", "name": "C0072973#ent", "pos": [22, 23]}}
{"token": ["NQO1", "binds", "and", "stabilizes", "several", "short-lived", "C0086376#ent", "<e1>", "including", "the", "tumor", "suppressors", "p53", "p73", "and", "the", "enzyme", "ornithine", "decarboxylase", "C1417932#ent", "<e2>", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [19, 20]}}
{"token": ["Two", "major", "F-actin-binding", "proteins", "Dictyostelium", "discoideum", "a", "C1333199#ent", "<e1>", "a", "17", "kDa", "C1823138#ent", "<e2>", "and", "two", "minor", "membrane", "polypeptides", "19", "kDa", "and", "15", "kDa", "were", "detected", "by", "this", "method", "."], "h": {"id": "C1333199", "name": "C1333199#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1823138", "name": "C1823138#ent", "pos": [12, 13]}}
{"token": ["Galactosyltransferase", "substrates", "inhibitors", "and", "C0033607#ent", "<e1>", "including", "soybean", "trypsin", "inhibitor", "pepstatin", ",", "leupeptin", ",", "and", "C0048024#ent", "<e2>", "failed", "to", "block", "sperm", "binding", "to", "porcine", "eggs", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0048024", "name": "C0048024#ent", "pos": [15, 16]}}
{"token": ["Northern", "blot", "analysis", "C0023816#ent", "<e1>", "expression", "in", "adipose", "tissue", "C0018050#ent", "<e2>", "only", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [9, 10]}}
{"token": ["C0154254#ent", "<e1>", "is", "a", "common", "and", "early", "feature", "of", "human", "C0019693#ent", "<e2>", "is", "often", "associated", "with", "inability", "to", "mount", "specific", "antibody", "responses", "to", "neoantigens", "and", "decreased", "in", "vitro", "B", "cell", "responses", "."], "h": {"id": "C0154254", "name": "C0154254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggested", "that", "the", "C0154254#ent", "<e1>", "found", "in", "C0019693#ent", "<e2>", "infected", "patients", "was", "associated", "with", "C0019693#ent", "<e2>", "replication", "."], "h": {"id": "C0154254", "name": "C0154254#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [9, 10]}}
{"token": ["In", "Drosophila", "neuromuscular", "junctions", "the", "C2326433#ent", "<e1>", "is", "also", "localized", "to", "C0263214#ent", "<e2>", "3", "]", "and", "has", "some", "characteristics", "expected", "of", "an", "anchoring", "protein"], "h": {"id": "C2326433", "name": "C2326433#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0263214", "name": "C0263214#ent", "pos": [11, 12]}}
{"token": ["The", "C1420703#ent", "<e1>", "portion", "of", "C3274808#ent", "<e2>", "contains", "a", "coiled-coil", "domain", "which", "mediates", "protein", "oligomerization", "for", "the", "oncogene", "constitutive", "activation", ",", "and", "several", "consensus", "sites", "protein", "interaction"], "h": {"id": "C1420703", "name": "C1420703#ent", "pos": [1, 2]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274808", "name": "C3274808#ent", "pos": [5, 6]}}
{"token": ["An", "amino-terminal", "coiled", "coil", "domain", "C1420703#ent", "<e1>", "is", "responsible", "for", "mediating", "oligomerization", "of", "the", "C3274808#ent", "<e2>", "resulting", "in", "constitutive", "activation", "of", "the", "TRK", "protein", "tyrosine", "kinase", "oncogenesis", "."], "h": {"id": "C1420703", "name": "C1420703#ent", "pos": [5, 6]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274808", "name": "C3274808#ent", "pos": [14, 15]}}
{"token": ["NK", "C1706438#ent", "<e1>", "for", "about", "20", "%", "of", "total", "CD8", "according", "to", "C1704691#ent", "<e2>", "and", "CD56", "expression", "."], "h": {"id": "C1706438", "name": "C1706438#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704691", "name": "C1704691#ent", "pos": [12, 13]}}
{"token": ["In", "cases", "of", "Santorini", "duct", "dominant", ",", "multiple", "stones", "or", "stricture", "of", "the", "MPD", ",", "ESWL", "should", "be", "combined", "with", "C1417544#ent", "<e1>", "and", "endoscopic", "stenting", "preventing", "recurrence", "of", "C0030305#ent", "<e2>", "pancreatic", "stones"], "h": {"id": "C1417544", "name": "C1417544#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [28, 29]}}
{"token": ["The", "possible", "interaction", "between", "C0022816#ent", "<e1>", "the", "endogenous", "C3537230#ent", "<e2>", "endomorphin-1", ",", "was", "examined", "in", "the", "same", "set-up", "."], "h": {"id": "C0022816", "name": "C0022816#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537230", "name": "C3537230#ent", "pos": [8, 9]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "compare", "lansoprazole", "to", "a", "standard", "dose", "C0034665#ent", "<e1>", "in", "the", "treatment", "of", "patients", "with", "C0014869#ent", "<e2>"], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0014869", "name": "C0014869#ent", "pos": [21, 22]}}
{"token": ["We", "conclude", "that", "early", "evening", "dosing", "with", "C0034665#ent", "<e1>", "is", "the", "treatment", "of", "choice", "for", "patients", "with", "C0014869#ent", "<e2>"], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0014869", "name": "C0014869#ent", "pos": [17, 18]}}
{"token": ["Sodium", "azide", "required", "catalase", "whereas", "C1414404#ent", "<e1>", "required", "cysteine", "to", "activate", "C0018358#ent", "<e2>"], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018358", "name": "C0018358#ent", "pos": [11, 12]}}
{"token": ["The", "radioactivity", "was", "separated", "by", "ion-exchange", "chromatography", "two", "major", "fractions", ":", "one", "C0815040#ent", "<e1>", ",", "the", "other", "C1333908#ent", "<e2>", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333908", "name": "C1333908#ent", "pos": [17, 18]}}
{"token": ["Various", "tests", "of", "the", "experimental", "data", "allow", "classification", "of", "each", "solute", "as", "acidic", ",", "basic", ",", "neutral", "(", "including", "strong", "or", "weak", "C0815040#ent", "<e1>", "or", "bases", ")", "and", "C1333908#ent", "<e2>", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1333908", "name": "C1333908#ent", "pos": [28, 29]}}
{"token": ["Seven", "antimicrobial", "substances", "three", "basic", ",", "three", "C0815040#ent", "<e1>", "and", "one", "C1333908#ent", "<e2>", "--", "were", "given", "in", "constant", "infusion", "experiments", "to", "dogs", "to", "monitor", "their", "distribution", "in", "the", "prostate", "gland"], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333908", "name": "C1333908#ent", "pos": [11, 12]}}
{"token": ["Thirty", "subjects", "with", "naturally", "acquired", "C0009443#ent", "<e1>", "got", "a", "100", "mg", "sustained", "release", "tablet", "containing", "C0031495#ent", "<e2>", "on", "one", "day", "and", "a", "placebo", "tablet", "on", "another", "day", "in", "double", "blind", "design"], "h": {"id": "C0009443", "name": "C0009443#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0031495", "name": "C0031495#ent", "pos": [15, 16]}}
{"token": ["The", "results", "of", "this", "small", "open-label", "extension", "study", "that", "patients", "with", "C0014547#ent", "<e1>", "were", "successfully", "converted", "to", "long-term", "C0772200#ent", "<e2>", "monotherapy", "demonstrated", "no", "adverse", "effects", "cognitive", "function", "mood", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0772200", "name": "C0772200#ent", "pos": [18, 19]}}
{"token": ["Amino", "acid", "starvation-induced", "C1413212#ent", "<e1>", "mRNA", "expression", "in", "MCF-7", "cells", "completely", "blocked", "by", "actinomycin", "D", "which", "suggested", "that", "the", "regulation", "of", "C1413212#ent", "<e1>", "mRNA", "by", "C2917660#ent", "<e1>", "occurred", "at", "transcriptional", "level"], "h": {"id": "C1413212", "name": "C1413212#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [25, 26]}}
{"token": ["The", "regulation", "of", "C1413212#ent", "<e1>", "mRNA", "in", "MCF-7", "cells", "C2917660#ent", "<e2>", "availability", "may", "play", "an", "important", "role", "in", "the", "progression", "and", "metastasis", "of", "human", "breast", "cancer"], "h": {"id": "C1413212", "name": "C1413212#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [9, 10]}}
{"token": ["Northern", "blot", "results", "showed", "that", "C1413212#ent", "<e1>", "mRNA", "in", "MCF-7", "cells", "constitutively", "expressed", "and", "significantly", "upregulated", "upon", "C2917660#ent", "<e2>", "starvation", "."], "h": {"id": "C1413212", "name": "C1413212#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [17, 18]}}
{"token": ["It", "is", "suggested", "that", "increased", "ANA", "and", "anti-DNA", "antibodies", "C0036420#ent", "<e1>", "associated", "with", "joint", "manifestations", "represents", "a", "systemic", "component", "this", "C0011644#ent", "<e2>", "with", "activation", "of", "the", "immune", "system", "similarities", "with", "generalized", "collagen", "diseases"], "h": {"id": "C0036420", "name": "C0036420#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0011644", "name": "C0011644#ent", "pos": [20, 21]}}
{"token": ["To", "investigate", "the", "effect", "of", "insulin-like", "growth", "factor-I", "C1334089#ent", "<e1>", ")", "and", "riluzole", ",", "a", "drug", "that", "inhibits", "C0017789#ent", "<e2>", "release", ",", "on", "axotomy", "induced", "motor", "neuron", "death"], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [18, 19]}}
{"token": ["Our", "previous", "study", "showed", "that", "extracellular-signal-regulated", "kinases", "1", "2", "(", "C1705791#ent", "<e1>", "1/2", ")", "were", "activated", "during", "C0007785#ent", "<e2>", "mice", "[", "J.", "Cereb", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [17, 18]}}
{"token": ["However", ",", "the", "effect", "of", "C1705791#ent", "<e1>", "1/2", "activation", "in", "C0007785#ent", "<e2>", "still", "unclear", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [10, 11]}}
{"token": ["C1442756#ent", "<e1>", "competitive", "inhibitors", "of", "Sp1-mediated", "betaMyHC", "reporter", "gene", "transactivation", "both", "Drosophila", "C0166027#ent", "<e2>", "and", "mouse", "C2C12", "myotubes", "."], "h": {"id": "C1442756", "name": "C1442756#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [12, 13]}}
{"token": ["Changes", "in", "triglycerides", "and", "C0002245#ent", "<e1>", "in", "the", "liver", "of", "C0024473#ent", "<e2>", "rats", "fed", "starch", "were", "not", "significant", "."], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024473", "name": "C0024473#ent", "pos": [10, 11]}}
{"token": ["Evening", "primrose", "oil", "gamma-linolenic", "acid", "C1425280#ent", "<e1>", ")", "to", "improve", "C0042402#ent", "<e2>", "eicosanoid", "synthesis", "in", "diabetes", ",", "correcting", "nerve", "blood", "flow", "NCV", "deficits", "."], "h": {"id": "C1425280", "name": "C1425280#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [10, 11]}}
{"token": ["Insulin", "binding", "tracer", "concentration", ",", "reflecting", "the", "number", "of", "C1334133#ent", "<e1>", "was", "initially", "normal", "but", "tended", "to", "decrease", "with", "C2926735#ent", "<e2>", "of", "cyclosporine", "administration", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [19, 20]}}
{"token": ["Under", "the", "conditions", "described", ",", "C0055091#ent", "<e1>", "hydrolyzed", "all", "of", "the", "common", "C0017083#ent", "<e2>", "studied", ",", "offering", "a", "broad", "spectrum", "of", "specificity", "."], "h": {"id": "C0055091", "name": "C0055091#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017083", "name": "C0017083#ent", "pos": [12, 13]}}
{"token": ["2", "patients", "had", "associated", "C0032285#ent", "<e1>", ",", "1", "patient", "had", "C0019693#ent", "<e2>", "1", "patient", "had", "erythema", "nodosum", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [10, 11]}}
{"token": ["Pneumocystis", "carinii", "an", "important", "opportunistic", "pulmonary", "pathogen", "that", "causing", "C0032285#ent", "<e1>", "in", "premature", "infants", "children", "with", "C0019693#ent", "<e2>", "patients", "of", "all", "ages", "receiving", "immunosuppressive", "agents"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [16, 17]}}
{"token": ["Pneumocystis", "carinii", "C0032285#ent", "<e1>", "has", "generally", "been", "regarded", "to", "be", "an", "uncommon", "opportunistic", "infection", "C0019693#ent", "<e2>", "infected", "individuals", "in", "sub-Saharan", "Africa"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [14, 15]}}
{"token": ["Future", "studies", "may", "provide", "new", "therapeutic", "modalities", "different", "C0029928#ent", "<e1>", "by", "aberrant", "regulation", "of", "apoptosis", "in", "ovarian", "cells", "including", "C0085215#ent", "<e2>", "polycystic", "ovarian", "syndrome"], "h": {"id": "C0029928", "name": "C0029928#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0085215", "name": "C0085215#ent", "pos": [19, 20]}}
{"token": ["The", "influence", "of", "C0055447#ent", "<e1>", "protein", "synthesis", "synovial", "fluid", "cells", "investigated", "in", "8", "patients", "suffering", "from", "C0003873#ent", "<e2>"], "h": {"id": "C0055447", "name": "C0055447#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["Studies", "on", "the", "imipramine", "and", "C0011685#ent", "<e1>", "metabolites", "in", "urine", "showed", "that", "the", "major", "effect", "of", "C0031184#ent", "<e2>", "is", "an", "inhibition", "of", "the", "2-hydroxylation", "of", "imipramine", "and", "C0011685#ent", "<e1>", "."], "h": {"id": "C0031184", "name": "C0031184#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [5, 6]}}
{"token": ["Acetyl", "phosphatidylethanolamine", "not", "replace", "C1450468#ent", "<e1>", "in", "the", "reconstitution", "of", "a", "Ca-2", "plus", "pump", "with", "C1706373#ent", "<e2>", "isolated", "from", "sacoplasmic", "reticulum"], "h": {"id": "C1450468", "name": "C1450468#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [15, 16]}}
{"token": ["P-Glycoprotein", "has", "well-defined", "lipid", "preferences", "with", "C1450468#ent", "<e1>", "activating", "the", "C1706373#ent", "<e2>", "and", "providing", "protection", "from", "thermal", "inactivation", "while", "fluid", "lipid", "mixtures", "are", "able", "to", "restore", "activity", "following", "delipidation", "."], "h": {"id": "C1450468", "name": "C1450468#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [10, 11]}}
{"token": ["We", "studied", "hydroxyamphetamine", "hydrobromide", "1%", "Paredrine", ")", "C0026961#ent", "<e1>", "in", "54", "patients", "with", "C0019937#ent", "<e2>", "determine", "its", "effectiveness", "in", "distinguishing", "preganglionic", "lesions", "postganglionic", "lesions", "."], "h": {"id": "C0026961", "name": "C0026961#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019937", "name": "C0019937#ent", "pos": [13, 14]}}
{"token": ["A", "29-year-old", "white", "man", "complained", "of", "episodic", "C0026961#ent", "<e1>", "his", "right", "eye", "on", "by", "strenuous", "exercise", "found", "to", "have", "a", "C0019937#ent", "<e2>", "association", "with", "a", "hypoplastic", "internal", "carotid", "artery"], "h": {"id": "C0026961", "name": "C0026961#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019937", "name": "C0019937#ent", "pos": [20, 21]}}
{"token": ["Aminoethylcysteine-ketimine", "(", "C0076399#ent", "<e1>", "strongly", "inhibits", "D-amino-acid", "oxidase", "C1413903#ent", "<e2>", ":", "oxygen", "oxidoreductase", "deaminating", ")", ",", "EC", "1.4.3.3", ")", "."], "h": {"id": "C0076399", "name": "C0076399#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413903", "name": "C1413903#ent", "pos": [8, 9]}}
{"token": ["Glycosylation", "of", "C1257966#ent", "<e1>", "is", "mediated", "by", "C1333828#ent", "<e2>", "UGTs", ")", ",", "which", "use", "UDP-sugars", ",", "such", "as", "UDP-glucose", ",", "as", "the", "glycosyl", "donor", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [7, 8]}}
{"token": ["A", "dominant-negative", "C1425471#ent", "<e1>", "mutant", "blocked", "activation", "of", "C1367731#ent", "<e2>", "by", "HIP-55", "showing", "that", "HIP-55", "activates", "the", "JNK1", "signaling", "pathway", "C1425471#ent", "<e1>", "."], "h": {"id": "C1367731", "name": "C1367731#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425471", "name": "C1425471#ent", "pos": [2, 3]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "clarify", "the", "mechanism(s", ")", "responsible", "for", "the", "C1710463#ent", "<e1>", "the", "human", "C1413882#ent", "<e2>"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413882", "name": "C1413882#ent", "pos": [18, 19]}}
{"token": ["Cefepime", "monotherapy", "was", "as", "effective", "as", ",", "and", "better", "tolerated", "than", ",", "C0071972#ent", "<e1>", "in", "the", "empirical", "treatment", "fever", "during", "C0023530#ent", "<e2>"], "h": {"id": "C0071972", "name": "C0071972#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [20, 21]}}
{"token": ["C0071972#ent", "<e1>", "is", "safe", "initial", "therapy", "in", "C0023530#ent", "<e2>", "febrile", "patients", "."], "h": {"id": "C0071972", "name": "C0071972#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [7, 8]}}
{"token": ["The", "C0673913#ent", "<e1>", "were", "screened", "for", "their", "in", "vitro", "inhibition", "potency", "towards", "farnesyl", "transferase", "C0170210#ent", "<e2>"], "h": {"id": "C0673913", "name": "C0673913#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0170210", "name": "C0170210#ent", "pos": [14, 15]}}
{"token": ["The", "present", "studies", "indicate", "that", "beta-adrenoceptor", "agonists", "analogues", "of", "C0002502#ent", "<e1>", "both", "act", "to", "inhibit", "C1420091#ent", "<e2>", "both", "stimulate", "cAMP-dependent", "protein", "kinase", "activity"], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420091", "name": "C1420091#ent", "pos": [15, 16]}}
{"token": ["Clinical", "studies", "that", "C0004057#ent", "<e1>", "intake", "to", "prevent", "myocardial", "and", "C0007785#ent", "<e2>", "associated", "with", "significant", "increase", "in", "upper", "gastrointestinal", "hemorrhage", "hospitalization", "and", "that", "nitroglycerin", "or", "long-acting", "nitrates", "significantly", "lower", "this", "risk", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [10, 11]}}
{"token": ["These", "results", "concur", "with", "those", "of", "other", "trials", "involving", "C0004057#ent", "<e1>", "to", "demonstrate", "the", "value", "of", "antiplatelet", "aggregation", "drugs", "the", "secondary", "prevention", "C0007785#ent", "<e2>"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [9, 10]}, "relation": "may_prevent", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [22, 23]}}
{"token": ["The", "C1823643#ent", "<e1>", "and", "H2", "genes", "highly", "C1512488#ent", "<e2>", ",", "differentially", "expressed", "in", "reproductive", "tissues", "appear", "to", "activate", "the", "same", "receptor", ",", "but", "their", "regulation", "is", "poorly", "understood", "."], "h": {"id": "C1823643", "name": "C1823643#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [7, 8]}}
{"token": ["The", "functional", "human", "hepatic", "asialoglycoprotein", "receptor", "ASGP-R", ")", "is", "a", "hetero-oligomer", "composed", "of", "two", "subunits", ",", "designated", "C1823643#ent", "<e1>", "and", "H2", ",", "which", "are", "highly", "C1512488#ent", "<e2>", "."], "h": {"id": "C1823643", "name": "C1823643#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [25, 26]}}
{"token": ["Here", "we", "demonstrate", "that", "C1367699#ent", "<e1>", "is", "an", "unstable", "protein", "with", "auto-polyubiquitination", "activity", "in", "vivo", "in", "vitro", "implying", "that", "C1367699#ent", "<e1>", "acts", "as", "a", "C0077678#ent", "<e1>"], "h": {"id": "C1367699", "name": "C1367699#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [24, 25]}}
{"token": ["In", "this", "article", ",", "we", "disclose", "a", "novel", "series", "of", "substituted", "4-benzyl-2", "H-phthalazin-1-ones", "that", "possess", "high", "inhibitory", "C0014442#ent", "<e1>", "and", "cellular", "potency", "both", "PARP-1", "and", "C1436356#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1436356", "name": "C1436356#ent", "pos": [25, 26]}}
{"token": ["The", "BRRS", "is", "a", "dominant", "C3899988#ent", "<e1>", "by", "cutaneous", "lipomas", "macrocephaly", ",", "intestinal", "polyps", "and", "developmental", "delay", "associated", "with", "C1430988#ent", "<e2>", "gene", "mutations"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [19, 20]}}
{"token": ["Sequence", "analysis", "that", "C1416925#ent", "<e1>", "is", "the", "human", "homologue", "of", "the", "recently", "described", "murine", "molecule", "C1416925#ent", "<e1>", "."], "h": {"id": "C1416925", "name": "C1416925#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416925", "name": "C1416925#ent", "pos": [3, 4]}}
{"token": ["The", "C1867020#ent", "<e1>", "a", "rare", "autosomal", "dominant", "that", "involves", "lesions", "of", "the", "C0240940#ent", "<e2>", ",", "malformed", "external", "ears", ",", "and", "absence", "of", "rudimentary", "nipples", "and", "breasts", "."], "h": {"id": "C1867020", "name": "C1867020#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0240940", "name": "C0240940#ent", "pos": [12, 13]}}
{"token": ["Theoretically", ",", "the", "coexistence", "of", "C0272315#ent", "<e1>", "thrombophilia", "in", "patients", "with", "C0684275#ent", "<e2>", "may", "cause", "the", "bleeding", "tendency", "to", "decline", "."], "h": {"id": "C0272315", "name": "C0272315#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0684275", "name": "C0684275#ent", "pos": [11, 12]}}
{"token": ["In", "patients", "with", "asthma", ",", "salmeterol", "and", "C0060657#ent", "<e1>", "increase", "lung", "function", "reduce", "C0004096#ent", "<e2>", "symptoms", "and", "improve", "quality", "of", "life", "compared", "with", "placebo", "."], "h": {"id": "C0060657", "name": "C0060657#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "the", "effects", "of", "beta2-adrenergic", "agonists", "salmeterol", "C0060657#ent", "<e1>", "on", "heart", "rate", "variability", "HRV", ")", "in", "adult", "C0004096#ent", "<e2>", "patients", "using", "time-domain", "measures", "of", "HRV", "."], "h": {"id": "C0060657", "name": "C0060657#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [18, 19]}}
{"token": ["We", "report", "here", "the", "cloning", "and", "primary", "sequence", "an", "M-200", "kD", "integrin", "alpha", "subunit", "associates", "with", "the", "C1416496#ent", "<e1>", "form", "a", "receptor", "for", "both", "laminin", "and", "C0009325#ent", "<e2>", "."], "h": {"id": "C1416496", "name": "C1416496#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [26, 27]}}
{"token": ["RNA/protein", "interaction", "studies", "revealed", "C1417613#ent", "<e1>", "the", "135", "nt", "C1705322#ent", "<e2>", "sequence", "."], "h": {"id": "C1417613", "name": "C1417613#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705322", "name": "C1705322#ent", "pos": [9, 10]}}
{"token": ["All", "the", "eight", "C3540772#ent", "<e1>", "studied", "were", "found", "to", "produce", "C0015278#ent", "<e2>", "exclusively", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015278", "name": "C0015278#ent", "pos": [10, 11]}}
{"token": ["The", "abnormally", "enhanced", "migration", "of", "Rhoh(-/-", ")", "HPCs", "is", "associated", "with", "increased", "C1419227#ent", "<e1>", "activity", "and", "translocation", "of", "C0139880#ent", "<e2>", "the", "cell", "membrane", "where", "it", "colocalizes", "with", "cortical", "filamentous-actin", "(", "F-actin", ")", "and", "lipid", "rafts"], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0139880", "name": "C0139880#ent", "pos": [18, 19]}}
{"token": ["The", "contribution", "of", "poor", "metabolic", "control", "C1959583#ent", "<e1>", "determined", "in", "isolated", "working", "hearts", "C0011860#ent", "<e2>", "BB", "Wistar", "rats"], "h": {"id": "C1959583", "name": "C1959583#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "binding", "and", "immunoprecipitation", "analyses", "that", "the", "protein-protein", "interaction", "C0001857#ent", "<e1>", "and", "caspase", "8", "decreased", "by", "the", "increase", "of", "C0001477#ent", "<e2>", "in", "vitro", "by", "the", "treatment", "of", "HEK293", "cells", "thapsigargin", "in", "vivo"], "h": {"id": "C0001857", "name": "C0001857#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [21, 22]}}
{"token": ["The", "fasting", "plasma", "level", "of", "reduced", "glutathione", "(", "C1260386#ent", "<e1>", ")", ",", "a", "methionine-derived", "tripeptide", ",", "is", "reduced", "in", "C0023890#ent", "<e2>", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [19, 20]}}
{"token": ["In", "the", "erythrocytes", ",", "C1260386#ent", "<e1>", "was", "affected", "by", "both", "these", "factors", "(", "age", "and", "C0023890#ent", "<e2>", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [15, 16]}}
{"token": ["The", "purified", "enzyme", "was", "free", "from", "steroid", "25-hydroxylase", "activity", "and", "that", "of", "26-", "or", "C0055530#ent", "<e1>", "but", "revealed", "some", "activity", "for", "C0005096#ent", "<e2>"], "h": {"id": "C0055530", "name": "C0055530#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0005096", "name": "C0005096#ent", "pos": [21, 22]}}
{"token": ["For", "example", ",", "in", "the", "Ames", "test", ",", "BHT", "is", "antimutagenic", "towards", "C0005080#ent", "<e1>", ",", "but", "increases", "the", "number", "of", "C0036117#ent", "<e2>", "induced", "by", "aflatoxin", "B1"], "h": {"id": "C0005080", "name": "C0005080#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [20, 21]}}
{"token": ["Regular", "screening", "patients", "on", "C0040233#ent", "<e1>", "maleate", "for", "tear", "film", "instability", "and", "C0314719#ent", "<e2>", "important", "and", "drug", "manufacturers", "explore", "the", "possibility", "of", "incorporating", "artificial", "tears", "C0040233#ent", "<e1>", "maleate", "preparation", "."], "h": {"id": "C0040233", "name": "C0040233#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0314719", "name": "C0314719#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "roles", "of", "PKC", "C1419007#ent", "<e1>", "in", "insulin-stimulated", "glucose", "uptake", "and", "C1420175#ent", "<e2>", "translocation", "in", "primary", "cultures", "rat", "skeletal", "muscle"], "h": {"id": "C1419007", "name": "C1419007#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [16, 17]}}
{"token": ["A", "diagnosis", "of", "C0154681#ent", "<e1>", "considered", "and", "zidovudine", ",", "lamivudine", "and", "C0132326#ent", "<e2>", "were", "started", "."], "h": {"id": "C0154681", "name": "C0154681#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0132326", "name": "C0132326#ent", "pos": [11, 12]}}
{"token": ["In", "this", "article", ",", "Dr.", "Bruckstein", "reviews", "the", "advantages", "of", "the", "enemas", "in", "the", "treatment", "of", "C0009324#ent", "<e1>", "briefly", "examines", "the", "potential", "benefits", "of", "the", "new", "oral", "C0036077#ent", "<e2>", "preparations", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [27, 28]}}
{"token": ["These", "findings", "suggest", "that", "further", "studies", "are", "needed", "to", "evaluate", "the", "clinical", "value", "the", "triple", "drug", "combination", "proguanil", ",", "atovaquone", "and", "C0010980#ent", "<e1>", "in", "the", "treatment", "of", "multi-drug", "resistant", "C0024530#ent", "<e2>", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [21, 22]}, "relation": "may_prevent", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [29, 30]}}
{"token": ["C0074710#ent", "<e1>", ",", "a", "dopamine", "D2/D3", "receptor", "agonist", "clinically", "in", "the", "treatment", "of", "C0030567#ent", "<e2>", "did", "not", "affect", "glutamate-induced", "calcium", "influx", "blocked", "dopaminergic", "neuronal", "death", "induced", "by", "glutamate", "."], "h": {"id": "C0074710", "name": "C0074710#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [13, 14]}}
{"token": ["We", "report", "on", "10", "patients", "with", "Kawasaki", "disease", "and", "C1839163#ent", "<e1>", "who", "were", "found", "to", "have", "a", "high", "incidence", "of", "C0010051#ent", "<e2>", "acute", "myocardial", "infarction"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010051", "name": "C0010051#ent", "pos": [20, 21]}}
{"token": ["flavokinase", "and", "C0060605#ent", "<e1>", "as", "well", "as", "those", "of", "C1258127#ent", "<e2>", "viz", ".", ","], "h": {"id": "C0060605", "name": "C0060605#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1258127", "name": "C1258127#ent", "pos": [9, 10]}}
{"token": ["Thirty", "women", "(", "28", "of", "childbearing", "age", "2", "in", "the", "menopause", ")", ",", "affected", "by", "C0700345#ent", "<e1>", "treated", "orally", "with", "a", "new", "antimycotic", "triazole", "derivative", ",", "C0064113#ent", "<e2>", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [26, 27]}}
{"token": ["Eighteen", "patients", "with", "the", "acute", "form", "13", "patients", "with", "the", "recurrent", "form", "of", "C0700345#ent", "<e1>", "1-day", "therapy", "(", "twice", "200", "mg", "of", "C0064113#ent", "<e2>", "in", "1", "day", ")", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "animals", "were", "injected", "with", "a", "combination", "of", "C0008783#ent", "<e1>", "and", "ketanserin", "or", "with", "an", "alpha-adrenoceptor", "antagonist", "C0031448#ent", "<e2>", ",", "5", "mg", "kg(-1", ")", ")", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [18, 19]}}
{"token": ["C0907533#ent", "<e1>", "overexpression", "of", "C1416659#ent", "<e2>", "but", "not", "KLF15", "potently", "inhibits", "peroxisome", "proliferator-activated", "receptor-gamma", "PPARgamma", ")", "expression", "with", "no", "effect", "the", "upstream", "regulators", "C/EBPbeta", "and", "C/EBPdelta", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416659", "name": "C1416659#ent", "pos": [4, 5]}}
{"token": ["These", "results", "suggest", "that", "C2346907#ent", "<e1>", "is", "an", "important", "component", "of", "innate", "resistance", "C0006840#ent", "<e2>", "and", "that", "C2346907#ent", "<e1>", "therapy", "may", "be", "a", "means", "to", "prevent", "disseminated", "candidiasis", "high-risk", "patients", "."], "h": {"id": "C2346907", "name": "C2346907#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [13, 14]}}
{"token": ["C0270612#ent", "<e1>", "with", "vanishing", "white", "matter", "VWM", ")", ",", "also", "called", "childhood", "ataxia", "central", "nervous", "system", "hypomyelination", "C1705452#ent", "<e2>", ")", ",", "is", "an", "autosomal", "recessive", "disease", "by", "mutations", "in", "any", "of", "the", "five", "genes", "encoding", "subunits", "of", "the", "eukaryotic", "translation", "initiation", "factor", "eIF2B"], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705452", "name": "C1705452#ent", "pos": [17, 18]}}
{"token": ["A", "new", "C0270612#ent", "<e1>", ",", "the", "CACH", "syndrome", "Childhood", "Ataxia", "Central", "nervous", "system", "Hypomyelination", ")", "or", "C1705452#ent", "<e2>", "(", "Vanishing", "White", "Matter", "was", "identified", "on", "clinical", "and", "MRI", "criteria", "."], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [2, 3]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705452", "name": "C1705452#ent", "pos": [16, 17]}}
{"token": ["Hepcidin", "or", "hepcidin-related", "therapeutics", "could", "find", "a", "place", "in", "the", "treatment", "of", "various", "diseases", "such", "as", "C1384665#ent", "<e1>", "and", "anemia", "of", "C0008679#ent", "<e2>"], "h": {"id": "C1384665", "name": "C1384665#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "several", "studies", "have", "suggested", "that", "C1384665#ent", "<e1>", "mutations", "may", "be", "involved", "in", "several", "C0008679#ent", "<e2>", "as", "Alzheimer's", "disease", "AD", ")", "and", "coronary", "heart", "disease", "but", "apparently", "paradoxically", "also", "with", "longevity", "."], "h": {"id": "C1384665", "name": "C1384665#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [15, 16]}}
{"token": ["The", "study", "was", "performed", "of", "clinico-biochemical", "effect", "of", "plasmapheresis", "(", "PA", ")", "in", "severe", "C0042721#ent", "<e1>", "mixed", "hepatitis", "and", "C0011226#ent", "<e2>"], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011226", "name": "C0011226#ent", "pos": [19, 20]}}
{"token": ["Total", "C1415537#ent", "<e1>", "activity", "was", "greater", "in", "complete", "C0156149#ent", "<e2>", "in", "partial", "ischemia", ",", "(", "P", "less", "than", "0.05", ")", "."], "h": {"id": "C1415537", "name": "C1415537#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0156149", "name": "C0156149#ent", "pos": [8, 9]}}
{"token": ["We", "show", "by", "C3887634#ent", "<e1>", "DNA", "fragmentation", "analyses", "the", "overexpression", "of", "C1538913#ent", "<e2>", ",", "Aph-1b", ",", "or", "Pen-2", "drastically", "lowered", "staurosporine-induced", "cellular", "toxicity", "."], "h": {"id": "C3887634", "name": "C3887634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1538913", "name": "C1538913#ent", "pos": [11, 12]}}
{"token": ["Both", "loss", "of", "iron", "binding", "and", "transferrin", "iodination", "either", "the", "C1417245#ent", "<e1>", "activated", "neutrophils", "were", "blocked", "by", "azide", "or", "C1413138#ent", "<e2>", "."], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [19, 20]}}
{"token": ["This", "study", "compares", "the", "effects", "on", "renal", "and", "vascular", "endothelial", "functions", "arterial", "stiffness", "monotherapy", "regimens", "of", "amlodipine", ",", "an", "L-type", "calcium", "antagonist", "and", "C0378675#ent", "<e1>", ",", "in", "patients", "with", "C0085580#ent", "<e2>"], "h": {"id": "C0378675", "name": "C0378675#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [29, 30]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "assess", "the", "effects", "of", "amlodipine", "and", "C0378675#ent", "<e1>", "on", "the", "cardiac", "sympathetic", "nervous", "system", "the", "neurohormonal", "status", "C0085580#ent", "<e2>"], "h": {"id": "C0378675", "name": "C0378675#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [24, 25]}}
{"token": ["Results", "suggest", "that", "C0378675#ent", "<e1>", "has", "an", "anti-proteinuric", "effect", "especially", "in", "patients", "with", "C0085580#ent", "<e2>"], "h": {"id": "C0378675", "name": "C0378675#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [13, 14]}}
{"token": ["NRAS", ",", "MYCN", ",", "CSFIR", ",", "MYB", ",", "MYC", ",", "C1704928#ent", "<e1>", ",", "HRASI", ",", "TP53", ",", "and", "C1704824#ent", "<e2>", "did", "not", "reveal", "any", "consistent", "alterations", "in", "tumour", "DNA"], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704824", "name": "C1704824#ent", "pos": [18, 19]}}
{"token": ["When", "C0023660#ent", "<e1>", "was", "added", "to", "C0282138#ent", "<e2>", "or", "verapamil", ",", "the", "low", "plasma", "levels", "of", "C0023660#ent", "<e1>", "depressed", "cardiac", "function", "the", "presence", "of", "either", "calcium", "channel", "blocking", "drug", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [6, 7]}}
{"token": ["The", "genome", "sequence", "M.", "jannaschii", "encodes", "two", "homologs", "of", "each", "large", "and", "small", "subunit", "forms", "the", "C0001156#ent", "<e1>", ",", "but", "the", "C0017337#ent", "<e2>", "are", "not", "cotranscribed", "."], "h": {"id": "C0001156", "name": "C0001156#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [21, 22]}}
{"token": ["The", "activation", "of", "C1384557#ent", "<e1>", "by", "extracellular", "matrix", "proteins", "regulated", "by", "C0059239#ent", "<e2>", "through", "an", "interaction", "between", "the", "PH", "domain", "C1384557#ent", "<e1>", "and", "the", "FERM", "domain", "C0059239#ent", "<e2>", "."], "h": {"id": "C1384557", "name": "C1384557#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [11, 12]}}
{"token": ["Following", "the", "period", "of", "circulatory", "arrest", "was", "a", "rise", "in", "both", "C3536742#ent", "<e1>", "levels", "that", "correlated", "nonlinearly", "with", "the", "C0720099#ent", "<e2>", "of", "circulatory", "arrest"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "the", "heart", "rate", "urinary", "excretion", "C3536742#ent", "<e1>", "are", "influenced", "by", "the", "C0720099#ent", "<e2>", "of", "salt", "loading"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [15, 16]}}
{"token": ["C1421449#ent", "<e1>", "(", "V", ")", "is", "a", "C0072522#ent", "<e2>", "of", "microvilli", "associated", "with", "formation", "."], "h": {"id": "C1421449", "name": "C1421449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}}
{"token": ["C1412125#ent", "<e1>", "induced", "a", "Gcn2p-dependent", "phosphorylation", "of", "C3539639#ent", "<e2>", "and", "translational", "activation", "of", "Gcn4p", ",", "the", "transcription", "factor", "mediates", "the", "general", "amino", "acid", "control", "response"], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539639", "name": "C3539639#ent", "pos": [7, 8]}}
{"token": ["One", "of", "the", "interstitial", "deletion", "DGS", "probands", "is", "monosomic", "for", "C3273410#ent", "<e1>", "but", "has", "two", "copies", "of", "the", "flanking", "C1425241#ent", "<e2>", "and", "BCR", "loci", "."], "h": {"id": "C3273410", "name": "C3273410#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1425241", "name": "C1425241#ent", "pos": [19, 20]}}
{"token": ["However", ",", "using", "antibodies", "specific", "to", "these", "two", "proteins", ",", "we", "demonstrate", "that", ",", "whereas", "C2986916#ent", "<e1>", "and", "C1416448#ent", "<e2>", "selectively", "hydrolyze", "PtdIns(3,4,5)P3", "in", "vitro", "only", "C2986916#ent", "<e1>", "hydrolyzes", "soluble", "Ins(1,3,4,5)P4", "."], "h": {"id": "C1416448", "name": "C1416448#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2986916", "name": "C2986916#ent", "pos": [15, 16]}}
{"token": ["Preliminary", "binding", "studies", "using", "lysates", "from", "p210(bcr/abl)-expressing", "cells", "indicate", "that", "both", "Ptyr", "C1416448#ent", "<e1>", "and", "Ptyr", "C2986916#ent", "<e2>", "bind", "to", "the", "PTB", "domain", "SHC", "but", "not", "to", "its", "SH2", "domain"], "h": {"id": "C1416448", "name": "C1416448#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2986916", "name": "C2986916#ent", "pos": [16, 17]}}
{"token": ["Benign", "C0016399#ent", "<e1>", "childhood", "with", "centro-temporal", "spikes", "(", "C2363129#ent", "<e2>", ")", "is", "one", "of", "the", "most", "common", "forms", "of", "epilepsy", "."], "h": {"id": "C0016399", "name": "C0016399#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2363129", "name": "C2363129#ent", "pos": [8, 9]}}
{"token": ["In", "humans", ",", "both", "the", "C3657721#ent", "<e1>", "selective", "inhibitor", "C0009035#ent", "<e2>", "and", "the", "non-selective", "inhibitor", "tranylcypromine", "increase", "serum", "melatonin", "levels", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009035", "name": "C0009035#ent", "pos": [9, 10]}}
{"token": ["The", "present", "study", "compared", "the", "abilities", "of", "PMA", "and", "MDMA", "to", "increase", "extracellular", "5-HT", "concentrations", "in", "animals", "with", "functional", "C3657721#ent", "<e1>", "and", "when", "C3657721#ent", "<e1>", "activity", "was", "inhibited", "by", "C0009035#ent", "<e1>", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0009035", "name": "C0009035#ent", "pos": [29, 30]}}
{"token": ["The", "same", "applies", "to", "other", "inhibitors", "of", "C3657721#ent", "<e1>", ",", "such", "as", "C0009035#ent", "<e2>", "and", "pargyline", "as", "well", "as", "selegiline", "(", "deprenyl", ")", "in", "higher", "concentrations", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009035", "name": "C0009035#ent", "pos": [12, 13]}}
{"token": ["C0001644#ent", "<e1>", "blocking", "drugs", "are", "of", "prophylactic", "value", "some", "patients", "with", "C0149931#ent", "<e2>", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [11, 12]}}
{"token": ["Antiarrhythmic", "and", "hemodynamic", "effects", "of", "the", "calcium", "channel", "antagonist", "C0042523#ent", "<e1>", "were", "compared", "with", "those", "of", "C0145904#ent", "<e2>", ",", "a", "congener", ",", "in", "open-chest", "pigs", "with", "anterior", "descending", "coronary", "artery", "ligation"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0145904", "name": "C0145904#ent", "pos": [16, 17]}}
{"token": ["Type", "1", "agents", "typified", "by", "C0042523#ent", "<e1>", ",", "its", "congeners", "(", "C0145904#ent", "<e2>", "and", "gallopamil", ")", "and", "diltiazem", ",", "prolong", "atrioventricular", "nodal", "conduction", "refractoriness", "with", "little", "effect", "on", "ventricular", "or", "atrial", "refractoriness", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0145904", "name": "C0145904#ent", "pos": [11, 12]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "determine", "the", "effect", "of", "C0887458#ent", "<e1>", "CSH", ")", "on", "growth", "hormone", "C3539616#ent", "<e2>", ")", "secretion", "in", "male", "swine", "."], "h": {"id": "C0887458", "name": "C0887458#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [18, 19]}}
{"token": ["Effects", "of", "C0887458#ent", "<e1>", "somatostatin-inhibiting", "agent-on", "serum", "growth", "hormone", "(", "C3539616#ent", "<e2>", ")", "levels", "and", "growth", "in", "juvenile", "grass", "carp", "Ctenopharyngodon", "idellus", "were", "studied", "."], "h": {"id": "C0887458", "name": "C0887458#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [10, 11]}}
{"token": ["C0887458#ent", "<e1>", "the", "75", "mg/kg", "BW", "dose", "decreased", "mean", "C3539616#ent", "<e2>", "concentrations", "(", "P", "<", ".05", ")", "compared", "to", "the", "0", "and", "25", "mg/kg", "BW", "groups", "."], "h": {"id": "C0887458", "name": "C0887458#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [9, 10]}}
{"token": ["C0009014#ent", "<e1>", ",", "a", "proposed", "alpha-noradrenergic", "receptor", "C0002763#ent", "<e2>", ",", "intensifies", "the", "aggression", "occuring", "during", "morphine-withdrawal", "or", "following", "the", "administration", "of", "apomorphine", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [7, 8]}}
{"token": ["Guanfacine", "is", "an", "alpha", "2-adrenergic", "that", "may", "have", "beneficial", "effects", "on", "attention", ",", "without", "the", "hypotensive", "or", "sedative", "effects", "C0009014#ent", "<e1>", ",", "which", "is", "often", "used", "as", "an", "alternative", "to", "C0002763#ent", "<e2>", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [30, 31]}}
{"token": ["Because", "of", "its", "homology", "with", "the", "Frizzled", "family", "G-protein-coupled", "receptors", "GPCR", ")", ",", "a", "likely", "candidate", "for", "an", "immediate", "C1423784#ent", "<e1>", "effector", "would", "be", "a", "C0752348#ent", "<e2>"], "h": {"id": "C1423784", "name": "C1423784#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [25, 26]}}
{"token": ["Recent", "studies", "suggest", "that", "C0242988#ent", "<e1>", "TRbeta", ")", "selective", "C2987634#ent", "<e2>", "have", "a", "profile", "in", "which", "cholesterol", "can", "be", "reduced", "with", "minimal", "tachycardia", "."], "h": {"id": "C0242988", "name": "C0242988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [9, 10]}}
{"token": ["One", "C0599532#ent", "<e1>", "group", "reacts", "rapidly", "unless", "L-tryptophan", ",", "ATP", ",", "and", "C1417500#ent", "<e2>", "+", "are", "present", "together", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [12, 13]}}
{"token": ["The", "rat", "hydrolase", "expressed", "in", "E.", "coli", "demonstrated", "enhanced", "activity", "in", "the", "presence", "of", "Mg2+", "C0599532#ent", "<e1>", ",", "whereas", "the", "recombinant", "human", "hydrolase", "stimulated", "by", "C1417500#ent", "<e2>", "+", "but", "was", "thiol-independent", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [25, 26]}}
{"token": ["Average", "doses", "of", "verapamil", "and", "C3536830#ent", "<e1>", "not", "sufficient", "in", "the", "C0003195#ent", "<e2>"], "h": {"id": "C3536830", "name": "C3536830#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [11, 12]}}
{"token": ["There", "was", "an", "inverse", "correlation", "between", "the", "plasma", "homocysteine", "concentration", "and", "C0012177#ent", "<e1>", "or", "protein", "intake", "a", "C0677666#ent", "<e2>", "SPI", ")", "was", "used", "as", "a", "protein", "source", "rats", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [11, 12]}, "relation": "chemical_structure_of", "t": {"id": "C0677666", "name": "C0677666#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "C0012177#ent", "<e1>", "linoleic", "acid", "lipoxygenase", "significantly", "reduced", "the", "nutritive", "quality", "of", "soybean", "protein", "C0677666#ent", "<e2>"], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [2, 3]}, "relation": "chemical_structure_of", "t": {"id": "C0677666", "name": "C0677666#ent", "pos": [15, 16]}}
{"token": ["One", "of", "the", "C0014442#ent", "<e1>", "participating", "in", "both", "biosynthesis", "and", "degradation", "is", "the", "C1412752#ent", "<e2>", "which", "is", "in", "Arabidopsis", "thaliana", "encoded", "by", "a", "small", "gene", "family", "six", "transcribed", "members"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412752", "name": "C1412752#ent", "pos": [13, 14]}}
{"token": ["For", "example", ",", "it", "may", "now", "be", "possible", "to", "block", ",", "selectively", ",", "subtypes", "of", "C1332759#ent", "<e1>", "the", "gastrointestinal", "tract", "C0031978#ent", "<e2>", "and", "other", "drugs", "that", "discriminate", "between", "subtypes", "of", "C1332759#ent", "<e1>"], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1332759", "name": "C1332759#ent", "pos": [15, 16]}}
{"token": ["The", "present", "study", "was", "performed", "to", "investigate", "the", "role", "of", "acetylcholine", "in", "regulating", "GH", "secretion", "by", "using", "C0031978#ent", "<e1>", ",", "which", "selectively", "blocks", "C1332759#ent", "<e2>"], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1332759", "name": "C1332759#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "our", "data", "demonstrated", "that", "stimulated", "peritoneal", "and", "J774.1", "macrophages", "express", "the", "lactate", "transporter", "MCT", ",", "and", "that", "C0175697#ent", "<e1>", "and", "TNFalpha", "regulate", "C3811697#ent", "<e2>", "mRNA", "and", "protein", "levels"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3811697", "name": "C3811697#ent", "pos": [24, 25]}}
{"token": ["It", "was", "also", "completely", "inhibited", "by", "the", "specific", "AMPA", "antagonist", "LY300164", "and", "by", "Joro", "spider", "toxin", "JSTx", ")", ",", "a", "selective", "C0001641#ent", "<e1>", "of", "AMPA", "receptors", "lack", "the", "edited", "C3890744#ent", "<e2>"], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3890744", "name": "C3890744#ent", "pos": [29, 30]}}
{"token": ["Interestingly", ",", "the", "effects", "of", "C3540808#ent", "<e1>", "blockade", "on", "C0164786#ent", "<e2>", "activation", ",", "cancer", "cell", "growth", "apoptosis", "could", "not", "be", "reversed", "by", "exogenously", "added", "oleic", "acid"], "h": {"id": "C3540808", "name": "C3540808#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [9, 10]}}
{"token": ["The", "diagnosis", "of", "C0042164#ent", "<e1>", "based", "on", "the", "finding", "of", "a", "cataractous", "lens", "and", "C0042165#ent", "<e2>", "unassociated", "with", "other", "identifiable", "causes", "of", "uveal", "inflammation", "."], "h": {"id": "C0042164", "name": "C0042164#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0042165", "name": "C0042165#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "active", "uveitis", "characterized", "as", "follows", ":", "5", "had", "C0042164#ent", "<e1>", "5", "panuveitis", "and", "the", "remaining", "11", "C0042165#ent", "<e2>"], "h": {"id": "C0042164", "name": "C0042164#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0042165", "name": "C0042165#ent", "pos": [18, 19]}}
{"token": ["Only", "after", "her", "infant", "son", "had", "a", "C0876973#ent", "<e1>", "the", "diagnosis", "of", "chronic", "granulomatous", "disease", "and", "her", "C0024138#ent", "<e2>", "erythematosus-like", "mucocutaneous", "lesions", "recognized", "as", "manifestations", "of", "her", "carrier", "status", "chronic", "granulomatous", "disease"], "h": {"id": "C0876973", "name": "C0876973#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [17, 18]}}
{"token": ["In", "previous", "study", ",", "we", "found", "that", "C0677666#ent", "<e1>", "SPH", ")", "prepared", "with", "the", "C0030946#ent", "<e2>", "from", "Bacillus", "amyloliquefaciens", ",", "strongly", "stimulates", "transcription", "of", "low", "density", "lipoprotein", "receptor", "LDL-R", ")", "."], "h": {"id": "C0677666", "name": "C0677666#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [14, 15]}}
{"token": ["C0677666#ent", "<e1>", "SPI", ")", "was", "digested", "with", "C0030946#ent", "<e2>", "to", "produce", "a", "peptides", "containing", "the", "low-molecular", "fraction", "(", "LD3", ")", "or", "a", "mixture", "of", "high-", "and", "low-molecular", "fractions", "(", "HD1", ")", "."], "h": {"id": "C0677666", "name": "C0677666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [7, 8]}}
{"token": ["IBa", "was", "sensitive", "to", "C0220821#ent", "<e1>", "and", "insensitive", "to", "the", "peptide", "toxins", "omega-agatoxin", "IVa", "C0211011#ent", "<e2>", "GVIa", ",", "and", "omega-conotoxin", "MVIIC"], "h": {"id": "C0220821", "name": "C0220821#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0211011", "name": "C0211011#ent", "pos": [14, 15]}}
{"token": ["C0221423#ent", "<e1>", "that", "may", "arise", "subsequent", "to", "gastric", "surgery", "C0017152#ent", "<e2>", "of", "the", "resected", "stomach", "inflammation", "of", "the", "anastomosis", ",", "anastomotic", "ulcers", "--", "with", "reservations", "--", "anastomotic", "carcinoma"], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [9, 10]}}
{"token": ["C0014130#ent", "<e1>", "as", "Cushing's", "disease", "polycystic", "ovary", "disease", "and", "C0271561#ent", "<e2>", "lead", "to", "increased", "body", "fat"], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0271561", "name": "C0271561#ent", "pos": [9, 10]}}
{"token": ["When", "pethidine", "and", "C0031376#ent", "<e1>", "were", "compared", "with", "C0030873#ent", "<e2>", ",", "the", "mean", "increases", "were", "lower", "following", "C0030873#ent", "<e2>", "but", "not", "to", "a", "statistically", "significant", "."], "h": {"id": "C0031376", "name": "C0031376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030873", "name": "C0030873#ent", "pos": [8, 9]}}
{"token": ["The", "data", "indicate", "that", "only", "the", "oligomeric", "form", "of", "C1414549#ent", "<e1>", "sufficient", "affinity/avidity", "to", "bind", "to", "an", "IgE", "C0350056#ent", "<e2>", "."], "h": {"id": "C1414549", "name": "C1414549#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0350056", "name": "C0350056#ent", "pos": [18, 19]}}
{"token": ["Previous", "injections", "of", "inhibitors", "of", "5-lipoxygenase", "(", "MK-886", ")", "or", "cyclooxygenase", "(", "aspirin", "or", "indomethacin", ")", "significantly", "decreased", "the", "magnitude", "of", "the", "C0034063#ent", "<e1>", "induced", "by", "C0885164#ent", "<e2>"], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0885164", "name": "C0885164#ent", "pos": [26, 27]}}
{"token": ["It", "is", "concluded", "that", "PAF", "plays", "an", "important", "role", "on", "the", "genesis", "of", "C0034063#ent", "<e1>", "induced", "by", "C0885164#ent", "<e2>", "the", "rat", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0885164", "name": "C0885164#ent", "pos": [17, 18]}}
{"token": ["C1705456#ent", "<e1>", "is", "the", "most", "abundant", "virulence", "factor", "expressed", "during", "C0006840#ent", "<e2>", "and", "the", "principal", "protein", "to", "induce", "antibody", "response", "C0006840#ent", "<e2>", "humans", "."], "h": {"id": "C1705456", "name": "C1705456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [10, 11]}}
{"token": ["This", "study", "investigates", "the", "role", "of", "C3273436#ent", "<e1>", "and", "its", "receptors", "ET-A", "and", "ET-B", "(", "C2348358#ent", "<e2>", "and", "ET-BR", ")", "in", "TM", "Ca(2+)-independent", "contractility", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2348358", "name": "C2348358#ent", "pos": [15, 16]}}
{"token": ["8", "years", "later", ",", "during", "1976", "and", "1977", ",", "they", "were", "given", "boosters", "containing", "C0051510#ent", "<e1>", "adsorbed", "Td", "with", "4", "C0039614#ent", "<e2>", "toxoid", "."], "h": {"id": "C0051510", "name": "C0051510#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039614", "name": "C0039614#ent", "pos": [20, 21]}}
{"token": ["Forty-six", "women", "in", "active", "labour", "developed", "C0015930#ent", "<e1>", "abdominal", "delivery", "randomized", "to", "receive", "0.25", "mg", "of", "C0039542#ent", "<e2>", "(", "subcutaneously", ")", "or", "magnesium", "sulphate", "a", "4-g", "bolus", "(", "intravenously", ")", "to", "decrease", "uterine", "activity"], "h": {"id": "C0015930", "name": "C0015930#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039542", "name": "C0039542#ent", "pos": [16, 17]}}
{"token": ["Comparators", "were", "first", "generation", "(", "C0008929#ent", "<e1>", ",", "tripolidine", ")", "and", "second", "generation", "terfenadine", ",", "cetirizine", ")", "C0019590#ent", "<e2>", "."], "h": {"id": "C0008929", "name": "C0008929#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019590", "name": "C0019590#ent", "pos": [17, 18]}}
{"token": ["We", "studied", "plasma", "levels", "behavioural", "effects", "of", "a", "newly", "developed", "controlled", "release", "formulation", "of", "C0080356#ent", "<e1>", "(", "VPA-CR", ")", "in", "children", "with", "C0014547#ent", "<e2>", "."], "h": {"id": "C0080356", "name": "C0080356#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [22, 23]}}
{"token": ["Presynaptic", "C1412122#ent", "<e1>", "localized", "in", "the", "C2984553#ent", "<e2>", "between", "axon", "terminal", "Schwann", "cell", "to", "be", "resistant", "to", "collagenase", "but", "not", "to", "papain", "treatment", "."], "h": {"id": "C1412122", "name": "C1412122#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2984553", "name": "C2984553#ent", "pos": [6, 7]}}
{"token": ["In", "their", "article", "on", "the", "use", "of", "barbiturates", "for", "the", "treatment", "of", "C0151740#ent", "<e1>", "traumatic", "brain", "injury", "Perez-Barcena", "and", "colleagues", "conclude", "that", "C0039925#ent", "<e2>", "was", "more", "effective", "than", "pentobarbital", "in", "decreasing", "intracranial", "pressure"], "h": {"id": "C0151740", "name": "C0151740#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [22, 23]}}
{"token": ["This", "study", "was", "conducted", "on", "10", "pediatric", "patients", "in", "whom", "C0151740#ent", "<e1>", "from", "head", "injury", "reduced", "by", "high-dose", "C0039925#ent", "<e2>", "administered", "for", "a", "prolonged", "period", "."], "h": {"id": "C0151740", "name": "C0151740#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [18, 19]}}
{"token": ["Insertion", "of", "the", "EMC", "virus", "sequence", "upstream", "of", "an", "C1412687#ent", "<e1>", "encoding", "either", "a", "wildtype", "or", "methotrexate", "resistant", "C0039667#ent", "<e2>", "DHFR", ")", "reduces", "DHFR", "translation", "up", "to", "10-fold", "in", "a", "monocistronic", "DHFR", "expression", "vector"], "h": {"id": "C1412687", "name": "C1412687#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [18, 19]}}
{"token": ["In", "mammals", ",", "the", "conserved", "C1538580#ent", "<e1>", "P", "bidirectional", "control", "promoter", "simultaneously", "expresses", "both", "the", "C1436356#ent", "<e2>", "RNase", "P", "RNA", "RNA", "polymerase", "II-", "III-dependent", "mechanisms", ",", "respectively", "."], "h": {"id": "C1538580", "name": "C1538580#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1436356", "name": "C1436356#ent", "pos": [15, 16]}}
{"token": ["Subcutaneous", "fondaparinux", "noninferior", "to", "C0206460#ent", "<e1>", "treatment", "in", "patients", "with", "C0002965#ent", "<e2>", "NSTEMI", ",", "and", "was", "more", "effective", "than", "usual", "care", "those", "with", "STEMI", "."], "h": {"id": "C0206460", "name": "C0206460#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [10, 11]}}
{"token": ["The", "influence", "of", "PGI2", "on", "the", "activity", "and", "on", "the", "inactivation", "of", "C3540772#ent", "<e1>", "participating", "in", "blood", "coagulation", "C1414504#ent", "<e2>", "and", "Factor", "Xa", "and", "fibrinolysis", "(", "plasmin", ")", "were", "investigated", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [18, 19]}}
{"token": ["The", "use", "of", "snake", "venom", "C3540772#ent", "<e1>", "or", "staphylocoagulase", "makes", "possible", "the", "C1414504#ent", "<e2>", "pathological", "forms", "of", "prothrombin", "lacking", "of", "gamma-carboxyglutamic", "acid", "incapable", "of", "complete", "activation", "into", "thrombin", "by", "the", "specific", "activator", ",", "factor", "Xa"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [12, 13]}}
{"token": ["C0008994#ent", "<e1>", "belongs", "to", "the", "family", "of", "C3541401#ent", "<e2>", ",", "which", "are", "synthetic", "analogues", "of", "pyrophosphate", "."], "h": {"id": "C0008994", "name": "C0008994#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541401", "name": "C3541401#ent", "pos": [7, 8]}}
{"token": ["Incubation", "of", "C0000970#ent", "<e1>", "with", "hepatic", "microsomes", "in", "a", "time", "dependent", "%", "decrease", "in", "C3887686#ent", "<e2>"], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887686", "name": "C3887686#ent", "pos": [14, 15]}}
{"token": ["Increased", "susceptibility", "to", "infections", "in", "patients", "with", "myelodysplastic", "syndromes", "C3273937#ent", "<e1>", ")", "is", "thought", "to", "be", "due", "to", "C0023530#ent", "<e2>", "as", "well", "as", "functional", "abnormalities", "neutrophils", "."], "h": {"id": "C3273937", "name": "C3273937#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [18, 19]}}
{"token": ["10", "We", "conclude", "that", "in", "the", "rabbit", "ear", "artery", ",", "tyramine", "depolarizes", "the", "smooth", "muscle", "membrane", "by", "releasing", "C0907533#ent", "<e1>", "acts", "on", "C0001640#ent", "<e2>", ",", "and", "directly", "by", "an", "action", "on", "the", "smooth", "muscle", "cells"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [22, 23]}}
{"token": ["C1414209#ent", "<e1>", "is", "a", "C1334043#ent", "<e2>", "of", "the", "Caenorhabditis", "elegans", "gene", ",", "which", "mediates", "vesicle", "fusion", "to", "the", "plasma", "membrane", "spermatids", "."], "h": {"id": "C1414209", "name": "C1414209#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}}
{"token": ["All-trans", "retinoic", "acid", "C0003873#ent", "<e1>", ")", "induced", "the", "phosphorylation", "and", "expression", "of", "C1333669#ent", "<e2>", "in", "the", "early", "and", "middle", "phase", "granulocyte", "differentiation", ",", "respectively", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333669", "name": "C1333669#ent", "pos": [12, 13]}}
{"token": ["C1337106#ent", "<e1>", "binds", "recombinant", "GR", "activation", "function", "1", "(", "C0812215#ent", "<e2>", ")", "with", "a", "1:2", "stoichiometry", "and", "a", "dissociation", "constant", "in", "the", "nanomolar", "range", "."], "h": {"id": "C1337106", "name": "C1337106#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [9, 10]}}
{"token": ["The", "C1333196#ent", "<e1>", "in", "neural", "cell", "damage", "well", "as", "apoptosis", "of", "glial", "cells", "to", "TNF-induced", "C1145670#ent", "<e2>"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [15, 16]}}
{"token": ["Consequently", ",", "overexpression", "of", "a", "dominant-negative", "C1335202#ent", "<e1>", "or", "application", "of", "the", "established", "cancer", "drug", "C0906802#ent", "<e2>", "interfered", "with", "experimental", "metastasis", "mice", "."], "h": {"id": "C1335202", "name": "C1335202#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "even", "in", "this", "late-stage", "degenerate", "cartilage", "C0247689#ent", "<e1>", "and", "not", "C0919336#ent", "<e2>", "activity", "was", "responsible", "for", "the", "release", "of", "the", "majority", "of", "aggrecan", "from", "the", "cartilage", "."], "h": {"id": "C0247689", "name": "C0247689#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [13, 14]}}
{"token": ["Reverse", "phase", "HPLC", "mass", "spectrometry", "that", "C3889249#ent", "<e1>", "contained", "at", "least", "three", "distinct", "C0164116#ent", "<e2>", "all", "of", "which", "copurified", "through", "three", "chromatography", "steps"], "h": {"id": "C3889249", "name": "C3889249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0164116", "name": "C0164116#ent", "pos": [13, 14]}}
{"token": ["Phosphatidylinositol", "3-kinase", "PI3-kinase", ")", "activity", "has", "been", "shown", "to", "be", "important", "in", "cellular", "signaling", "receptors", "associated", "with", "C1421249#ent", "<e1>", "receptors", "coupled", "to", "small", "or", "C0752348#ent", "<e2>"], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [24, 25]}}
{"token": ["Sciatic", "nerve", "transection", "an", "injury", "that", "induces", "Schwann", "cell", "expression", "of", "NRG-1", ",", "alters", "C0243036#ent", "<e1>", "expression", "in", "DRG", "and", "C0035334#ent", "<e2>", "."], "h": {"id": "C0243036", "name": "C0243036#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [20, 21]}}
{"token": ["Here", "we", "followed", "the", "C1539479#ent", "<e1>", "of", "individual", "Foxp3(+)CD4(+)CD25(+", ")", "thymocytes", "and", "T", "cells", "in", "vivo", "C0524889#ent", "<e2>", "TCR", ")", "transgenic", "mice", "express", "a", "restricted", "but", "polyclonal", "repertoire", "of", "TCRs", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0524889", "name": "C0524889#ent", "pos": [16, 17]}}
{"token": ["Quantitative", "analysis", "hypothetical", "protein", "FLJ10849", ",", "hypothetical", "protein", "FLJ20113", "and", "C1422492#ent", "<e1>", "of", "hsp90", "ATPase", "homologue", "1", "(", "C1412886#ent", "<e2>", ")", "revealed", "levels", "comparable", "between", "DS", "and", "controls", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412886", "name": "C1412886#ent", "pos": [18, 19]}}
{"token": ["A", "phase", "III", "randomised", ",", "double-blind", ",", "placebo", "controlled", "study", "conducted", "to", "compare", "the", "efficacy", "and", "adverse", "effects", "C0038633#ent", "<e1>", "and", "cimetidine", "in", "the", "short-term", "management", "of", "C0013295#ent", "<e2>"], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [18, 19]}, "relation": "may_prevent", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [27, 28]}}
{"token": ["We", "conclude", "that", "C0038633#ent", "<e1>", "is", "an", "effective", "agent", "for", "the", "treatment", "of", "C0013295#ent", "<e2>"], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [13, 14]}}
{"token": ["Drugs", "commonly", "implicated", "in", "DRAPEs", "were", "systemic", "steroids", "digoxin", ",", "nonsteroidal", "anti-inflammatory", "agents", "alpha-methyldopa", ",", "calcium", "channel", "blockers", "beta-blockers", ",", "theophylline", ",", "C0016860#ent", "<e1>", ",", "sympathomimetics", ",", "thiazides", ",", "and", "C4048284#ent", "<e2>", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [30, 31]}}
{"token": ["Commonly", "implicated", "drugs", "were", "methyldopa", ",", "hydrochlorothiazide", ",", "ampicillin", ",", "C0016860#ent", "<e1>", ",", "digoxin", ",", "tetracycline", ",", "aminophylline", ",", "phenytoin", ",", "C4048284#ent", "<e2>", ",", "and", "tricyclic", "antidepressants"], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [21, 22]}}
{"token": ["Because", "of", "the", "different", "biochemical", "properties", "of", "AC1", "and", "C1426119#ent", "<e1>", ",", "these", "two", "C3540790#ent", "<e2>", "may", "have", "distinct", "functions", "."], "h": {"id": "C1426119", "name": "C1426119#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [14, 15]}}
{"token": ["Antibodies", "to", "both", "viral", "main", "core", "protein", "C1413246#ent", "<e1>", ")", "and", "to", "virus", "specific", "membrane", "associated", "C0072522#ent", "<e2>", "(", "gp", "61", ")", "were", "detected", "in", "five", "of", "those", "."], "h": {"id": "C1413246", "name": "C1413246#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [16, 17]}}
{"token": ["C1413246#ent", "<e1>", "is", "a", "C0072522#ent", "<e2>", "that", "is", "abundant", "in", "hematopoietic", "cells"], "h": {"id": "C1413246", "name": "C1413246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [4, 5]}}
{"token": ["C1413246#ent", "<e1>", ",", "CD63", ",", "CD81", ",", "and", "CD82", "are", "C0072522#ent", "<e2>", "of", "unknown", "function", "which", "belong", "to", "the", "tetraspan", "superfamily"], "h": {"id": "C1413246", "name": "C1413246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}}
{"token": ["C0072132#ent", "<e1>", "PE", ")", "belongs", "to", "a", "group", "of", "C3541394#ent", "<e2>", "that", "specifically", "recognise", "the", "imino", "acid", "proline"], "h": {"id": "C0072132", "name": "C0072132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}}
{"token": ["The", "subcellular", "distribution", "of", "C0072132#ent", "<e1>", "and", "of", "cation-sensitive", "neutral", "endopeptidase", "two", "C3541394#ent", "<e2>", "actively", "metabolizing", "many", "neuropeptides", ",", "was", "determined", "in", "homogenates", "of", "rabbit", "brain", "."], "h": {"id": "C0072132", "name": "C0072132#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [12, 13]}}
{"token": ["A", "number", "of", "autoimmune", "diseases", "C0037274#ent", "<e1>", "coincide", "with", "C0042900#ent", "<e2>", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [9, 10]}}
{"token": ["The", "results", "suggest", "that", "the", "C1414919#ent", "<e1>", "mediated", "release", "of", "[(3)H]noradrenaline", "is", "due", "to", "C0033036#ent", "<e2>", "resulting", "from", "increased", "Cl", "(", "?", ")"], "h": {"id": "C1414919", "name": "C1414919#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "leucine-responsive", "regulatory", "protein", "C1705231#ent", "<e1>", ")", "acts", "as", "a", "positive", "modulator", "of", "C1283620#ent", "<e2>", "expression", "."], "h": {"id": "C1705231", "name": "C1705231#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1283620", "name": "C1283620#ent", "pos": [15, 16]}}
{"token": ["We", "studied", "62", "patients", "affected", "by", "the", "C0795950#ent", "<e1>", "a", "polymalformative", "familial", "syndrome", "combining", "frequent", "congenital", "corpus", "callosum", "agenesis", "mental", "retardation", "psychotic", "episodes", "C0235025#ent", "<e2>", "and", "some", "dysmorphic", "features"], "h": {"id": "C0795950", "name": "C0795950#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [23, 24]}}
{"token": ["Clinical", "symptoms", "urodynamic", "findings", "and", "urological", "treatment", "35", "patients", "with", "C0005697#ent", "<e1>", "by", "Parkinson's", "disease", "11", "patients", ")", ",", "C0026769#ent", "<e2>", "10", "patients", ")", ",", "and", "spinocerebellar", "degeneration", "14", "patients", ")", "were", "reviewed", "retrospectively", "."], "h": {"id": "C0005697", "name": "C0005697#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [19, 20]}}
{"token": ["Using", "yeast", "two-hybrid", "screening", "we", "have", "identified", "a", "novel", "interaction", "between", "occludin", "and", "the", "C0077678#ent", "<e1>", "a", "member", "of", "the", "C1825027#ent", "<e2>"], "h": {"id": "C0077678", "name": "C0077678#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1825027", "name": "C1825027#ent", "pos": [20, 21]}}
{"token": ["Abnormal", "angiogenesis", "plays", "a", "key", "role", "in", "C0012634#ent", "<e1>", "of", "aging", "such", "as", "heart", "disease", "certain", "cancers", ",", "and", "C0015397#ent", "<e2>", "age-related", "macular", "degeneration"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [19, 20]}}
{"token": ["The", "indications", "for", "utilization", "of", "this", "device", "in", "the", "detection", "and", "follow-up", "of", "many", "C0012634#ent", "<e1>", "other", "than", "glaucoma", "and", "C0015397#ent", "<e2>", "be", "expanded", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [20, 21]}}
{"token": ["Ingested", "coliforms", "Escherichia", "coli", "Citrobacter", "freundii", "Enterobacter", "agglomerans", "Enterobacter", "cloacae", "C0519030#ent", "<e1>", "and", "Klebsiella", "oxytoca", "bacterial", "pathogens", "Salmonella", "typhimurium", "Yersinia", "enterocolitica", "C0302361#ent", "<e2>", "Legionella", "gormanii", "and", "Campylobacter", "jejuni", "increased", "resistance", "to", "free", "chlorine", "residuals"], "h": {"id": "C0519030", "name": "C0519030#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0302361", "name": "C0302361#ent", "pos": [21, 22]}}
{"token": ["C0740394#ent", "<e1>", "induced", "by", "C0937932#ent", "<e2>", "inhibition", "causes", "intrarenal", "oxidative", "stress", "which", "contributes", "to", "the", "development", "of", "the", "systemic", "hypertension", "the", "renal", "abnormalities", "induced", "by", "increased", "uric", "acid"], "h": {"id": "C0740394", "name": "C0740394#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0937932", "name": "C0937932#ent", "pos": [4, 5]}}
{"token": ["Laryngeal", "sarcoidosis", "occur", "in", "isolation", "or", "as", "a", "component", "of", "C0036202#ent", "<e1>", "it", "may", "produce", "C0019825#ent", "<e2>", ",", "dysphagia", ",", "and", "dyspnea", "."], "h": {"id": "C0036202", "name": "C0036202#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019825", "name": "C0019825#ent", "pos": [15, 16]}}
{"token": ["An", "electroencephalogram", "showed", "that", "they", "suffer", "from", "C0014547#ent", "<e1>", ",", "indicating", "that", "C1334148#ent", "<e2>", "is", "essential", "for", "proper", "brain", "function"], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334148", "name": "C1334148#ent", "pos": [12, 13]}}
{"token": ["Suppressive", "therapy", "C0249458#ent", "<e1>", "more", "effective", "than", "episodic", "therapy", "with", "C0249458#ent", "<e1>", "reducing", "the", "frequency", "of", "recurrences", "of", "C0019345#ent", "<e1>", "prolonging", "the", "time", "to", "first", "recurrence", "and", "was", "also", "similarly", "well-tolerated", "."], "h": {"id": "C0249458", "name": "C0249458#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0019345", "name": "C0019345#ent", "pos": [18, 19]}}
{"token": ["Studies", "have", "assessed", "whether", "nonselective", "muscarinic", "antagonists", "decrease", "the", "effects", "of", "cocaine", "because", "many", "of", "the", "C0005098#ent", "<e1>", "analogues", "are", "also", "C0242947#ent", "<e2>"], "h": {"id": "C0005098", "name": "C0005098#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0242947", "name": "C0242947#ent", "pos": [21, 22]}}
{"token": ["The", "effect", "of", "the", "use", "of", "C0008809#ent", "<e1>", "patient", "outcome", "the", "cost", "of", "C1136254#ent", "<e2>", "investigated", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [6, 7]}, "relation": "has_therapeutic_class", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [13, 14]}}
{"token": ["While", "predominantly", "identified", "using", "antiproliferative", "assays", ",", "the", "biological", "activity", "these", "new", "C2001522#ent", "<e1>", "encompasses", "significant", "antiprotozoal", ",", "C1442872#ent", "<e2>", ",", "phytotoxic", "and", "antiviral", "applications"], "h": {"id": "C2001522", "name": "C2001522#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1442872", "name": "C1442872#ent", "pos": [18, 19]}}
{"token": ["Groups", "of", "lean", ",", "obese", ",", "and", "C0011860#ent", "<e1>", "and", "SHR/N-cp", "rats", "were", "administered", "the", "a-glucosidase", "inhibitor", "C0066535#ent", "<e2>", "(", "150", "mg/kg", "diet", ",", "ad", "libitum", "from", "8", "until", "15", "weeks", "of", "age", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0066535", "name": "C0066535#ent", "pos": [17, 18]}}
{"token": ["Both", "had", "C0553548#ent", "<e1>", "progressed", "to", "panophthalmitis", "and", "C1282208#ent", "<e2>"], "h": {"id": "C0553548", "name": "C0553548#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1282208", "name": "C1282208#ent", "pos": [8, 9]}}
{"token": ["These", "data", "demonstrate", "that", "C1412228#ent", "<e1>", "is", "a", "potent", "C1519837#ent", "<e2>", "ethanol-induced", "neuronal", "cell", "death"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1519837", "name": "C1519837#ent", "pos": [9, 10]}}
{"token": ["Pituitary", "adenylate", "cyclase-activating", "polypeptide", "C1412228#ent", "<e1>", ")", "has", "been", "shown", "to", "be", "a", "potent", "C1519837#ent", "<e2>", "global", "and", "focal", "ischemia"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1519837", "name": "C1519837#ent", "pos": [14, 15]}}
{"token": ["The", "isolation", "of", "stable", "transferents", "that", "C0669365#ent", "<e1>", "or", "repressibly", "express", "C0003776#ent", "<e2>", "possible", "the", "analysis", "of", "regulatory", "signals", "influencing", "expression", "of", "the", "argininosuccinate", "synthetase", "gene"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003776", "name": "C0003776#ent", "pos": [11, 12]}}
{"token": ["This", "change", "was", "associated", "with", "increased", "expression", "of", "C1332739#ent", "<e1>", "and", "increased", "levels", "of", "its", "gene", "product", "C1448777#ent", "<e2>", "KAP", ")", ",", "which", "inhibits", "the", "G(1)/S", "transition", "of", "the", "cell", "cycle", "dephosphorylating", "cyclin-dependent", "kinases"], "h": {"id": "C1332739", "name": "C1332739#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1448777", "name": "C1448777#ent", "pos": [17, 18]}}
{"token": ["Excess", "copper", "is", "effluxed", "from", "mammalian", "cells", "the", "C0022716#ent", "<e1>", "or", "Wilson", "P-type", "ATPases", "(", "MNK", "and", "C0019202#ent", "<e2>", ",", "respectively", ")", "."], "h": {"id": "C0022716", "name": "C0022716#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [17, 18]}}
{"token": ["Capillary", "zone", "electrophoresis", "employed", "for", "the", "determination", "of", "C0009079#ent", "<e1>", "using", "an", "end-column", "amperometric", "detection", "at", "a", "C0524928#ent", "<e2>", "fiber", "array", "microdisk", "electrode", "with", "simplified", "capillary/electrode", "alignment", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "the", "VMS", "neurons", "are", "endowed", "with", "a", "novel", "C0017337#ent", "<e1>", ",", "rat", "Rhombex-29", ",", "that", "is", "sensitive", "to", "C0018440#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018440", "name": "C0018440#ent", "pos": [22, 23]}}
{"token": ["Collectively", ",", "these", "results", "suggest", "that", "C1336681#ent", "<e1>", ",", "as", "a", "downstream", "molecule", "C1710304#ent", "<e2>", ",", "may", "be", "involved", "in", "the", "pathophysiology", "of", "inflammatory", "arthritis"], "h": {"id": "C1336681", "name": "C1336681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [13, 14]}}
{"token": ["Primary", "HASMC", "pretreated", "with", "inhibitors", "of", "p38", "or", "p42/p44", "ERK", "MAPK", ",", "but", "not", "phosphatidylinositol", "3-kinase", "showed", "a", "significant", "decrease", "in", "C1336681#ent", "<e1>", "release", "on", "IL-1beta", "and", "C1710304#ent", "<e2>", "treatment", "."], "h": {"id": "C1336681", "name": "C1336681#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [27, 28]}}
{"token": ["Angiopoietin-like", "protein", "3", "4", "(", "Angptl3", "and", "C1423931#ent", "<e1>", ")", "are", "two", "members", "of", "the", "C3275275#ent", "<e2>"], "h": {"id": "C1423931", "name": "C1423931#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3275275", "name": "C3275275#ent", "pos": [15, 16]}}
{"token": ["Preferential", "methylation", "of", "maternal", "C1706112#ent", "<e1>", "was", "observed", "in", "C1709407#ent", "<e2>", "and", "Peg1/Mest", "of", "juvenile", "oocytes", "and", "in", "Snrpn", "of", "juvenile", "and", "adult", "oocytes", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709407", "name": "C1709407#ent", "pos": [9, 10]}}
{"token": ["Both", "are", "produced", "by", "the", "cleavage", "of", "double-stranded", "RNA", "precursors", "C1333218#ent", "<e1>", ",", "a", "member", "of", "the", "Rnase", "III", "family", "C1309483#ent", "<e2>", "and", "both", "guide", "the", "RNA-induced", "silencing", "complex", "cleave", "specifically", "RNAs", "sharing", "sequence", "identity", "them", "."], "h": {"id": "C1333218", "name": "C1333218#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1309483", "name": "C1309483#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "molecular", "epidemiological", "study", "C0034494#ent", "<e1>", "in", "Arctic", "countries", "comparing", "a", "panel", "of", "novel", "Greenland", "C1875400#ent", "<e2>", "to", "a", "larger", "cohort", "of", "viral", "sequences", "both", "Arctic", "and", "Baltic", "regions", "."], "h": {"id": "C0034494", "name": "C0034494#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [17, 18]}}
{"token": ["We", "developed", "a", "transgenic", "model", "C1511573#ent", "<e1>", "recombinase-mediated", "activation", "of", "a", "constitutively", "active", "mouse", "C1704918#ent", "<e2>", "N1ICD(+", ")", ")", "and", "studied", "transgene", "activation", "in", "Tie2-expressing", "lineages", "."], "h": {"id": "C1511573", "name": "C1511573#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704918", "name": "C1704918#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "was", "designed", "to", "assess", "whether", "any", "differences", "exist", "among", "C0003364#ent", "<e1>", "regard", "to", "progression", "of", "C3534591#ent", "<e2>", "albuminuria", "in", "human", "subjects", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3534591", "name": "C3534591#ent", "pos": [18, 19]}}
{"token": ["We", "have", "demonstrated", "that", "C4084890#ent", "<e1>", "is", "a", "target", "for", "serine", "phosphorylation", "by", "C0010531#ent", "<e2>", "PKA", ")", ",", "a", "process", "that", "is", "essential", "to", "maximizing", "C4084890#ent", "<e1>", "activity", "."], "h": {"id": "C4084890", "name": "C4084890#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [13, 14]}}
{"token": ["In", "keeping", "with", "the", "postulated", "role", "of", "this", "protein", ",", "the", "C0751865#ent", "<e1>", "increases", "in", "hepatic", "triacylglycerols", "phospholipids", ",", "and", "C0008385#ent", "<e2>", "smaller", "in", "females", "than", "in", "males", "."], "h": {"id": "C0751865", "name": "C0751865#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [20, 21]}}
{"token": ["The", "rhamnose", "pathway", "C0017337#ent", "<e1>", "were", "similar", "in", "sequence", "to", "those", "of", "(", "C0013371#ent", "<e2>", ")", "Dysenteriae", "1", "Flexneri", ",", "but", "the", "other", "C0017337#ent", "<e1>", "showed", "distant", "or", "no", "similarity"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013371", "name": "C0013371#ent", "pos": [13, 14]}}
{"token": ["Among", "the", "completed", "genomic", "sequences", "Enterobacteriaceae", ",", "C0017337#ent", "<e1>", "specifying", "all", "three", "proline", "biosynthetic", "can", "be", "discerned", "in", "E.", "coli", "C0013371#ent", "<e2>", ",", "Salmonella", "enterica", "Serratia", "marcescens", "Erwinia", "carotovora", "Yersinia", ",", "Photorhabdus", "luminescens", "and", "Sodalis", "glossinidius", "strain", "morsitans", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013371", "name": "C0013371#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "C1707839#ent", "<e1>", "was", "shown", "to", "induce", "an", "increase", "in", "C0113519#ent", "<e2>", "."], "h": {"id": "C1707839", "name": "C1707839#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0113519", "name": "C0113519#ent", "pos": [11, 12]}}
{"token": ["There", "is", "overlap", "with", "the", "C0039082#ent", "<e1>", "reported", "by", "Mart\u00ednez", "et", "al.", "[", "1987", "]", ",", "C0265245#ent", "<e2>", "Miller", "syndrome", "Gen\u00e9e-Wiedemann", "syndrome", ",", "and", "a", "C0039082#ent", "<e1>", "reported", "briefly", "by", "Warburg", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0265245", "name": "C0265245#ent", "pos": [16, 17]}}
{"token": ["The", "C0039082#ent", "<e1>", "the", "most", "common", "form", "of", "C0265245#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0265245", "name": "C0265245#ent", "pos": [8, 9]}}
{"token": ["The", "purpose", "of", "the", "present", "study", "was", "to", "investigate", "if", "temporo-spatial", "clustering", "and", "outbreaks", ",", "characteristics", "of", "C0009450#ent", "<e1>", "could", "be", "found", "in", "C0003615#ent", "<e2>", "cases", "in", "a", "defined", "Swedish", "population"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0003615", "name": "C0003615#ent", "pos": [23, 24]}}
{"token": ["The", "ability", "of", "several", "detergents", "(", "Triton", "X-100", "MEGA-9", ",", "C0041420#ent", "<e1>", "20", ",", "C0041420#ent", "<e1>", "80", ",", "digitonin", ",", "Lubrol", "PX", "and", "C0068941#ent", "<e1>", "to", "solubilise", "5", "alpha-reductase", "was", "studied", "."], "h": {"id": "C0041420", "name": "C0041420#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0068941", "name": "C0068941#ent", "pos": [23, 24]}}
{"token": ["In", "a", "larval", "C0014894#ent", "<e1>", "of", "Drosophila", "mojavensis", "are", "C0002085#ent", "<e2>", "whose", "products", "preferentially", "hydrolyze", "alpha-naphthyl", "esters", "whereas", "the", "majority", "of", "the", "C0002085#ent", "<e2>", "hydrolyze", "preferentially", "beta-naphthyl", "esters"], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}}
{"token": ["We", "used", "the", "reactions", "of", "relaxation", "of", "supercoiled", "DNA", "catalysed", "by", "C0012920#ent", "<e1>", "C1705556#ent", "<e2>", "and", "by", "topoisomerase", "II", "C1705556#ent", "<e2>", ",", "and", "also", "the", "reaction", "of", "decatenation", "of", "DNA", "networks", "by", "topoisomerase", "II"], "h": {"id": "C0012920", "name": "C0012920#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "C3539920#ent", "<e1>", "graphics", "characterized", "essential", "features", "of", "C0086376#ent", "<e2>", "in", "each", "compartment", "."], "h": {"id": "C3539920", "name": "C3539920#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["rMTC", "6", "-", "23", "cells", "were", "devoid", "of", "C1418388#ent", "<e1>", ",", "PC4", ",", "and", "PC5", "but", "expressed", "furin", "and", "C1418600#ent", "<e2>", "."], "h": {"id": "C1418388", "name": "C1418388#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418600", "name": "C1418600#ent", "pos": [19, 20]}}
{"token": ["C1418388#ent", "<e1>", "can", "effect", "dibasic", "cleavage", "PSS", "whereas", "C1418600#ent", "<e2>", "is", "without", "influence", "on", "PSS", "processing", "at", "least", "within", "the", "constitutive", "secretory", "pathway"], "h": {"id": "C1418388", "name": "C1418388#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418600", "name": "C1418600#ent", "pos": [8, 9]}}
{"token": ["Two", "other", "novel", "mammalian", "proprotein-processing", "enzymes", "are", "C1418388#ent", "<e1>", "(", "also", "known", "as", "PC3", ")", "and", "C1418600#ent", "<e2>", "."], "h": {"id": "C1418388", "name": "C1418388#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418600", "name": "C1418600#ent", "pos": [16, 17]}}
{"token": ["C1418388#ent", "<e1>", ",", "but", "not", "C1418600#ent", "<e2>", ",", "exogenously", "coexpressed", "with", "PSS", "in", "COS-7", "cells", "significant", "conversion", "to", "SS-14", "but", "not", "SS-28", "."], "h": {"id": "C1418388", "name": "C1418388#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418600", "name": "C1418600#ent", "pos": [5, 6]}}
{"token": ["Of", "these", "drugs", ",", "C1161318#ent", "<e1>", "its", "derivatives", "as", "well", "as", "the", "C0040615#ent", "<e2>", "chlorpromazine", ",", "have", "been", "shown", "to", "promote", "riboflavinuria", "in", "both", "animals", "and", "man", "."], "h": {"id": "C1161318", "name": "C1161318#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [12, 13]}}
{"token": ["The", "C1332772#ent", "<e1>", "cDNA", "is", "approximately", "5.7", "kb", "pairs", "and", "encodes", "1447", "C3539946#ent", "<e2>"], "h": {"id": "C1332772", "name": "C1332772#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [12, 13]}}
{"token": ["A", "transcription", "factor", "complex", "identified", "that", "binds", "to", "the", "C0033223#ent", "<e1>", "sequence", ",", "which", "we", "name", "C1422035#ent", "<e2>", ",", "for", "PCB-binding", "factor", "."], "h": {"id": "C0033223", "name": "C0033223#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422035", "name": "C1422035#ent", "pos": [16, 17]}}
{"token": ["To", "examine", "whether", "long-term", "inhibition", "of", "iNOS", "may", "rescue", "C0039902#ent", "<e1>", "mice", "from", "developing", "congestive", "heart", "failure", "we", "disrupted", "C0669372#ent", "<e2>", "crossing", "C0039902#ent", "<e1>", "mice", "with", "iNOS", "knockout", "mice"], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [19, 20]}}
{"token": ["C0017612#ent", "<e1>", "patients", "who", "performed", "physical", "activity", "C0018681#ent", "<e2>", "and", "nausea", ",", "symptoms", "that", "simulated", "a", "sudden", "rise", "in", "intraocular", "pressure"], "h": {"id": "C0017612", "name": "C0017612#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [7, 8]}}
{"token": ["C1705347#ent", "<e1>", "frequently", "coexists", "with", "other", "C0270932#ent", "<e2>", "other", "diabetic", "complications", ",", "but", "C1705347#ent", "<e1>", "may", "be", "isolated", ",", "frequently", "preceding", "the", "detection", "of", "other", "complications", "."], "h": {"id": "C0270932", "name": "C0270932#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705347", "name": "C1705347#ent", "pos": [0, 1]}}
{"token": ["Results", "indicated", "that", "increasing", "C1705924#ent", "<e1>", "fertilizer", "levels", "significantly", "improve", "C0009262#ent", "<e2>", "content", "in", "different", "plant", "parts", "and", "stages", "."], "h": {"id": "C1705924", "name": "C1705924#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [10, 11]}}
{"token": ["Accordingly", ",", "we", "substituted", "these", "and", "other", "divergent", "C3814396#ent", "<e1>", "SRS", "residues", "with", "the", "corresponding", "residues", "of", "CYP3A4", "and/or", "C3714750#ent", "<e2>", "."], "h": {"id": "C3814396", "name": "C3814396#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714750", "name": "C3714750#ent", "pos": [19, 20]}}
{"token": ["Cyclosporine", "is", "extensively", "metabolized", "by", "cytochrome-P450", "3A", "C3814396#ent", "<e1>", ")", "enzymes", "in", "the", "liver", "and", "intestine", "including", "the", "C3714750#ent", "<e2>", "isoenzyme", "."], "h": {"id": "C3814396", "name": "C3814396#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3714750", "name": "C3714750#ent", "pos": [18, 19]}}
{"token": ["C0165631#ent", "<e1>", "is", "a", "new", "naphthoic", "acid", "derivative", "potent", "C0035339#ent", "<e2>", "and", "antiinflammatory", "properties", "developed", "for", "the", "topical", "treatment", "acne", "vulgaris"], "h": {"id": "C0165631", "name": "C0165631#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "all", "three", "forms", "of", "C0022660#ent", "<e1>", "bound", "to", "arfaptin", "2", "with", "C1412504#ent", "<e2>", "showing", "the", "strongest", "binding", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412504", "name": "C1412504#ent", "pos": [14, 15]}}
{"token": ["C0042870#ent", "<e1>", "to", "elevated", "levels", "of", "the", "endogenous", "inhibitor", "protein", "C0010531#ent", "<e2>", "kidney", ",", "but", "not", "heart", ",", "muscle", ",", "pancreas", ",", "or", "brain", "."], "h": {"id": "C0042870", "name": "C0042870#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [10, 11]}}
{"token": ["Crosscutting", "government", "objectives", "and", "headline", "targets", "for", "addressing", "poverty", ",", "disadvantage", "and", "health", "inequalities", "supplement", "the", "C1417725#ent", "<e1>", "health", "improvement", "targets", "on", "smoking", ",", "C0001975#ent", "<e2>", ",", "physical", "activity", "teenage", "pregnancy", "child", "immunization"], "h": {"id": "C1417725", "name": "C1417725#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [24, 25]}}
{"token": ["In", "this", "study", ",", "the", "role", "of", "interdomain", "interactions", "involving", "the", "C1412521#ent", "<e1>", "and", "C2", "domains", "the", "mechanism", "of", "activation", "of", "C3539645#ent", "<e2>", "was", "investigated", "."], "h": {"id": "C1412521", "name": "C1412521#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [21, 22]}}
{"token": ["NEP", "cells", "differentiate", "into", "motoneurons", "immunoreactive", "for", "C0008407#ent", "<e1>", "ChAT", ")", "and", "the", "low-affinity", "neurotrophin", "receptor", "C1335268#ent", "<e2>", ")", "in", "both", "mass", "and", "clonal", "culture"], "h": {"id": "C0008407", "name": "C0008407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335268", "name": "C1335268#ent", "pos": [16, 17]}}
{"token": ["Seven", "of", "10", "children", "with", "C0949691#ent", "<e1>", "and", "8", "of", "16", "children", "with", "a", "variety", "of", "C0175166#ent", "<e2>", "antibodies", "to", "native", "type", "I", "collagen"], "h": {"id": "C0949691", "name": "C0949691#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0175166", "name": "C0175166#ent", "pos": [16, 17]}}
{"token": ["Possible", "causes", "of", "C0013404#ent", "<e1>", "can", "be", "classified", "pathophysiologically", "as", "obstructive", "or", "restrictive", "ventilatory", "disorders", "C0854416#ent", "<e2>", "abnormal", "central", "regulation", "breathing", "."], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0854416", "name": "C0854416#ent", "pos": [15, 16]}}
{"token": ["The", "most", "frequent", "causes", "of", "sickness", "certification", "according", "to", "diagnostic", "groups", "were", "C0012634#ent", "<e1>", "of", "the", "respiratory", "system", "C0026857#ent", "<e2>", "mental", "disorders", "and", "injuries", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0026857", "name": "C0026857#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "characterized", "the", "effect", "of", "C2936567#ent", "<e1>", "the", "turnover", "of", "C4277588#ent", "<e2>", "and", "activation", "of", "ERKs", "during", "development", "of", "the", "chick", "embryo", "retina"], "h": {"id": "C2936567", "name": "C2936567#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4277588", "name": "C4277588#ent", "pos": [12, 13]}}
{"token": ["The", "decrease", "in", "phosphatidylserine", "synthesis", "correlated", "with", "the", "down", "regulation", "of", "C1419056#ent", "<e1>", "activity", "by", "C0010531#ent", "<e2>"], "h": {"id": "C1419056", "name": "C1419056#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [15, 16]}}
{"token": ["The", "biosynthesis", "of", "C1136012#ent", "<e1>", ",", "a", "family", "of", "C3179052#ent", "<e2>", "peptide", "(", "NRP", ")", "antitumor", "agents", "provides", "an", "ideal", "system", "to", "study", "a", "hybrid", "PK/NRP", "natural", "product", "with", "significant", "biomedical", "value"], "h": {"id": "C1136012", "name": "C1136012#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3179052", "name": "C3179052#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "transformation", "by", "the", "C0079972#ent", "<e1>", "oncogene", "is", "not", "mediated", "by", "the", "activation", "of", "C0139030#ent", "<e2>"], "h": {"id": "C0079972", "name": "C0079972#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0139030", "name": "C0139030#ent", "pos": [17, 18]}}
{"token": ["Fine", "specificity", "determined", "by", "using", "a", "panel", "of", "overlapping", "30-amino-acid-long", "synthetic", "peptides", "subsequently", "using", "smaller", "C0030956#ent", "<e1>", "to", "precisely", "map", "the", "CTL", "domain", "on", "C3539699#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [24, 25]}}
{"token": ["Either", "overexpression", "of", "C1706016#ent", "<e1>", "or", "increased", "PR1b", "and", "C1831907#ent", "<e2>", "expression", "in", "transgenic", "rice", "plants", "confer", "increased", "resistance", "to", "rice", "blast", "."], "h": {"id": "C1706016", "name": "C1706016#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1831907", "name": "C1831907#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "C1420062#ent", "<e1>", "mutant", "neurons", "display", "reduced", "levels", "of", "activated", "C0812234#ent", "<e2>", "compared", "with", "wild-type", "counterparts", ",", "consistent", "with", "enhanced", "filopodial", "lengths", "observed", "on", "mutant", "growth", "cones"], "h": {"id": "C1420062", "name": "C1420062#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [11, 12]}}
{"token": ["A", "33-year-old", "man", "with", "a", "6-month", "history", "of", "C0035455#ent", "<e1>", "and", "bronchial", "asthma", "referred", "to", "our", "hospital", "with", "C0162296#ent", "<e2>", ",", "severe", "anemia", ",", "hypoxemia", ",", "mononeuropathy", "multiplex", "and", "renal", "insufficiency", "hematuria", "."], "h": {"id": "C0035455", "name": "C0035455#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162296", "name": "C0162296#ent", "pos": [18, 19]}}
{"token": ["C0920270#ent", "<e1>", "null", "mouse", "embryos", "have", "elevated", "C3890378#ent", "<e2>", "mRNA", "in", "spleen", "primordia", "prior", "to", "atrophy", ",", "while", "C3890378#ent", "<e2>", "seems", "to", "be", "repressed", "by", "C0920270#ent", "<e1>", "during", "organogenesis", "of", "the", "spleens", "of", "wild-type", "mice"], "h": {"id": "C0920270", "name": "C0920270#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890378", "name": "C3890378#ent", "pos": [7, 8]}}
{"token": ["This", "result", "suggests", "that", "expression", "of", "Aldh1", "protein", "negatively", "regulated", "by", "C0920270#ent", "<e1>", "and", "that", "abnormal", "expression", "of", "C3890378#ent", "<e2>", "in", "C0920270#ent", "<e1>", "null", "mice", "cause", "loss", "of", "splenic", "precursor", "cells", "aberrant", "retinoic", "acid", "metabolism", "."], "h": {"id": "C0920270", "name": "C0920270#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3890378", "name": "C3890378#ent", "pos": [18, 19]}}
{"token": ["The", "treatment", "is", "based", "on", "C1823643#ent", "<e1>", "and", "H2-blockers", "and", "C0012694#ent", "<e2>"], "h": {"id": "C1823643", "name": "C1823643#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [10, 11]}}
{"token": ["Fetal", "dopaminergic", "and", "C1332759#ent", "<e1>", "neurotransmitter", "concentrations", "were", "unaffected", "by", "prenatal", "C1422070#ent", "<e2>", "exposure", "."], "h": {"id": "C1332759", "name": "C1332759#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [11, 12]}}
{"token": ["Dyslipidemias", "in", "patients", "with", "coronary", "heart", "disease", "a", "greater", "risk", "of", "C0151744#ent", "<e1>", "comparable", "dyslipidemias", "in", "people", "C0015674#ent", "<e2>"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [17, 18]}}
{"token": ["Post-paracentesis", "circulatory", "dysfunction", "(", "C1413594#ent", "<e1>", ")", "may", "occur", "after", "LVP", "and", "is", "characterized", "by", "C0020625#ent", "<e2>", ",", "azotemia", ",", "and", "an", "increase", "in", "plasma", "renin", "activity", "."], "h": {"id": "C1413594", "name": "C1413594#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [15, 16]}}
{"token": ["C1416418#ent", "<e1>", "mRNA", "is", "expressed", "C0669365#ent", "<e2>", "in", "both", "lymphoid", "and", "nonlymphoid", "tissues"], "h": {"id": "C1416418", "name": "C1416418#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [5, 6]}}
{"token": ["When", "C0937898#ent", "<e1>", "was", "administered", "in", "the", "early", "phase", "C0149931#ent", "<e2>", ",", "the", "percentage", "of", "pain-free", "patients", "at", "2", "h", "rose", "to", "84", "%", "."], "h": {"id": "C0937898", "name": "C0937898#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [9, 10]}}
{"token": ["pet122", "mutants", "fail", "to", "produce", "C0763047#ent", "<e1>", "which", "is", "the", "polypeptide", "product", "the", "C1705322#ent", "<e2>", "but", "produce", "normal", "amounts", "mature", "COX3", "mRNA", "."], "h": {"id": "C0763047", "name": "C0763047#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705322", "name": "C1705322#ent", "pos": [13, 14]}}
{"token": ["A", "31-year-old", "white", "woman", "with", "biopsy", "verified", "C0031036#ent", "<e1>", "diagnosed", "in", "1981", ",", "developed", "6", "years", "later", "recurrent", "C0000737#ent", "<e2>", "rectal", "bleeding", "weight", "loss"], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [18, 19]}}
{"token": ["Our", "case", "represents", "a", "protean", "clinical", "manifestation", "C0031036#ent", "<e1>", "expands", "the", "differential", "diagnosis", "C0000737#ent", "<e2>"], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [13, 14]}}
{"token": ["C0031036#ent", "<e1>", "appeared", "following", "serum", "hepatitis", "caused", "arthromyalgia", ",", "C0000737#ent", "<e2>", "prolonged", "fever", "of", "unknown", "origin", ",", "peripheral", "polyneuropathy", "blood", "hypertension", "and", "renal", "insufficiency"], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [9, 10]}}
{"token": ["In", "a", "series", "of", "120", "patients", "with", "C0031036#ent", "<e1>", "PAN", ")", ",", "50", "had", "gastrointestinal", "manifestations", "34", "had", "transient", "C0000737#ent", "<e2>", "regressed", "spontaneously", "or", "in", "response", "to", "corticosteroid", "therapy", "required", "no", "further", "investigation", "."], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [19, 20]}}
{"token": ["This", "study", "describes", "a", "sensitive", "enzyme-linked", "immunosorbent", "assay", "the", "detection", "of", "the", "glucuronide", "conjugate", "C0378583#ent", "<e1>", "a", "putative", "C3536822#ent", "<e2>", "metabolite", "that", "may", "be", "used", "as", "a", "biomarker", "of", "exposure", "to", "pyrethroids", "."], "h": {"id": "C0378583", "name": "C0378583#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3536822", "name": "C3536822#ent", "pos": [18, 19]}}
{"token": ["The", "current", "biomaterials", "available", "are", "polyparadiaxanone", "(", "C0271829#ent", "<e1>", ")", ",", "polygycolide", "acid", "(", "PGA", ")", ",", "and", "C0525166#ent", "<e2>", "PLLA", ")", "."], "h": {"id": "C0271829", "name": "C0271829#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0525166", "name": "C0525166#ent", "pos": [18, 19]}}
{"token": ["On", "neurological", "examination", "the", "left", "trapezius", "sternomastoid", "muscles", ",", "motor", "function", "3/5", "and", "wide", "C0006430#ent", "<e1>", "on", "the", "neck", ",", "shoulder", "and", "C1824218#ent", "<e2>", "was", "present", "."], "h": {"id": "C0006430", "name": "C0006430#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1824218", "name": "C1824218#ent", "pos": [22, 23]}}
{"token": ["Unlike", "major", "histocompatibility", "complex", "class", "I", "CD1b", "molecules", ",", "which", "need", "beta(2)m", "to", "exit", "the", "ER", ",", "C1413210#ent", "<e1>", "can", "be", "expressed", "on", "the", "cell", "surface", "either", "a", "C1420192#ent", "<e2>", "associated", "with", "."], "h": {"id": "C1413210", "name": "C1413210#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [28, 29]}}
{"token": ["The", "membrane", "localization", "C1413672#ent", "<e1>", "CPM", ")", "and", "carboxypeptidase", "D", "C1413667#ent", "<e2>", ")", "make", "them", "ideally", "situated", "to", "regulate", "kinin", "activity"], "h": {"id": "C1413672", "name": "C1413672#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413667", "name": "C1413667#ent", "pos": [10, 11]}}
{"token": ["Peri-locus", "coeruleus", "infusions", "of", "either", "the", "cholinergic", "agonist", "C0053526#ent", "<e1>", ",", "or", "the", "C2746076#ent", "<e2>", ",", "clonidine", ",", "were", "used", "to", "enhance", "or", "suppress", "neuronal", "discharge", "activity", ",", "respectively", "."], "h": {"id": "C0053526", "name": "C0053526#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2746076", "name": "C2746076#ent", "pos": [13, 14]}}
{"token": ["S-Adenosyl-L-homocysteine", "(", "SAH", ")", "C1334064#ent", "<e1>", "catalyzes", "breakdown", "of", "C1825840#ent", "<e2>", ",", "which", "arises", "after", "S-adenosylmethionine-dependent", "methylation", ",", "into", "adenosine", "and", "homocysteine", "."], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [9, 10]}}
{"token": ["Treatment", "of", "various", "peripheral", "and", "neural", "cell", "lines", "either", "the", "cholesterol-extracting", "agent", "methyl-beta-cyclodextrin", "or", "the", "hydroxymethyl", "glutaryl-CoA", "reductase", "inhibitor", "C0024027#ent", "<e1>", "resulted", "in", "a", "drastic", "increase", "of", "secreted", "C0379526#ent", "<e2>", "cleaved", "soluble", "APP", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0379526", "name": "C0379526#ent", "pos": [28, 29]}}
{"token": ["C0024027#ent", "<e1>", "did", "not", "change", "the", "amounts", "of", "full-length", "or", "C0379526#ent", "<e2>", "processed", "amyloid", "precursor", "protein", "APP", ")", ",", "or", "presenilin", "1", "PS1", ")", "in", "either", "sex", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0379526", "name": "C0379526#ent", "pos": [10, 11]}}
{"token": ["At", "ultrasound", "control", "days", "later", ",", "the", "C0029927#ent", "<e1>", "not", "visible", ",", "while", "the", "C0010709#ent", "<e2>", "still", "present", "."], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [14, 15]}}
{"token": ["From", "this", "experience", "in", "routine", "maternal", "sonography", "a", "C0029927#ent", "<e1>", "the", "hepatic", "hilum", "also", "suggest", "Type", "III", "biliary", "atresia", "a", "C0010709#ent", "<e2>", "."], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [20, 21]}}
{"token": ["In", "33", "patient", "endometriosis", "treated", "by", "operative", "laparoscopy-electrocauterization", "of", "foci", "in", "20", "women", ",", "C0029927#ent", "<e1>", "resection", "in", "9", "and", "C0010709#ent", "<e2>", "extrication", "in", "4", "."], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [20, 21]}}
{"token": ["Compared", "with", "nonviable", "segments", ",", "viable", "segments", "had", "significantly", "higher", "C0009447#ent", "<e1>", "at", "rest", "(", "P", "<", "0.001", ")", "and", "C0012963#ent", "<e2>", "P", "<", "0.001", ")", "."], "h": {"id": "C0009447", "name": "C0009447#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012963", "name": "C0012963#ent", "pos": [20, 21]}}
{"token": ["The", "majority", "of", "patients", "(", "15/19", ")", "who", "responded", "to", "treatment", "had", "residual", "C1565662#ent", "<e1>", "up", "to", "30", "months", "of", "C0038317#ent", "<e2>", "treatment", "."], "h": {"id": "C1565662", "name": "C1565662#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [20, 21]}}
{"token": ["The", "fluorescence", "of", "Trp-226", "was", "suppressed", "by", "incubation", "of", "C0067533#ent", "<e1>", "with", "the", "self-complementary", "octanucleotide", "TGACGTCA", "(", "C1511573#ent", "<e2>", ")", "due", "to", "binding", "of", "the", "oligonucleotide", "to", "C0067533#ent", "<e1>", "."], "h": {"id": "C0067533", "name": "C0067533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "a", "strong", "repression", "of", "both", "basal", "and", "induced", "C1826732#ent", "<e1>", "transcription", "was", "observed", "following", "expression", "of", "a", "truncated", "version", "C0812382#ent", "<e2>", "."], "h": {"id": "C1826732", "name": "C1826732#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [21, 22]}}
{"token": ["Indian", "hedgehog", "Ihh", ")", ",", "C1826732#ent", "<e1>", "(", "Ptc", ")", ",", "and", "C0812382#ent", "<e2>", "are", "expressed", "at", "low", "levels", "in", "the", "endometrial", "epithelium", "day", "1", "of", "pregnancy", "."], "h": {"id": "C1826732", "name": "C1826732#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [12, 13]}}
{"token": ["C0017547#ent", "<e1>", "axons", "of", "crayfish", "were", "C0857393#ent", "<e2>", "in", "sodium-free", "external", "media", "containing", "hydrazinium", ",", "hydroxylamine", ",", "or", "guanidinium", "ions"], "h": {"id": "C0017547", "name": "C0017547#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0857393", "name": "C0857393#ent", "pos": [6, 7]}}
{"token": ["Highest", "activities", "(", "greater", "than", "50", "nmol/min", "per", "nmol", "C0534137#ent", "<e1>", ")", "were", "found", "for", "N-demethylation", "of", "C0005096#ent", "<e2>", "and", "aminopyrine", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005096", "name": "C0005096#ent", "pos": [17, 18]}}
{"token": ["Compared", "with", "control", ",", "mean", "NaE", "was", "significantly", "increased", "in", "C2700553#ent", "<e1>", "and", "was", "normal", "in", "essential", "hypertension", ",", "C0035067#ent", "<e2>", "chronic", "renal", "failure"], "h": {"id": "C2700553", "name": "C2700553#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035067", "name": "C0035067#ent", "pos": [19, 20]}}
{"token": ["The", "epidermal", "keratinocyte", "a", "main", "source", "of", "C1366566#ent", "<e1>", ",", "suggesting", "the", "involvement", "of", "various", "C3875321#ent", "<e2>"], "h": {"id": "C1366566", "name": "C1366566#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3875321", "name": "C3875321#ent", "pos": [15, 16]}}
{"token": ["Four", "H.", "ducreyi", "strains", ",", "previously", "shown", "to", "be", "avirulent", "in", "the", "temperature-dependent", "rabbit", "model", "for", "C0007947#ent", "<e1>", ",", "did", "not", "produce", "either", "C1709986#ent", "<e2>", "or", "LspA2", "in", "vitro"], "h": {"id": "C0007947", "name": "C0007947#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1709986", "name": "C1709986#ent", "pos": [23, 24]}}
{"token": ["The", "C1417585#ent", "<e1>", "GATA-1", "requires", "direct", "physical", "interaction", "the", "cofactor", "friend", "GATA-1", "(", "C2827368#ent", "<e2>", ")", "for", "its", "essential", "role", "in", "erythroid", "and", "megakaryocytic", "development", "."], "h": {"id": "C1417585", "name": "C1417585#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2827368", "name": "C2827368#ent", "pos": [13, 14]}}
{"token": ["IGF-I", "therapy", "demonstrates", "mixed", "therapeutic", "results", "in", "the", "treatment", "of", "peripheral", "nerve", "injury", "C0021847#ent", "<e1>", ",", "and", "motor", "neuron", "diseases", "as", "C0002736#ent", "<e2>"], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [21, 22]}}
{"token": ["Recent", "work", "concerning", "MMPs", "in", "patients", "with", "C0021847#ent", "<e1>", ",", "myopathy", ",", "spinal", "cord", "injury", "and", "C0002736#ent", "<e2>", "ALS", ")", ",", "and", "in", "corresponding", "animal", "models", "is", "discussed", "in", "this", "review", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "the", "incidence", "of", "entrapment", "C0021847#ent", "<e1>", "in", "patients", "with", "C0002736#ent", "<e2>", "ALS", ")", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "further", "demonstrated", "that", "C0006931#ent", "<e1>", "increases", "mitochondrial", "permeability", "activation", "of", "Bax", "and", "C1705526#ent", "<e2>", "in", "a", "JNK-dependent", "manner", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [14, 15]}}
{"token": ["Differential", "diagnoses", "hypocalcified", "forms", "of", "amelogenesis", "imperfecta", "C0162530#ent", "<e1>", "conditions", "leading", "to", "early", "tooth", "loss", "Kostmann's", "disease", "C0221023#ent", "<e2>", "Chediak-Hegashi", "syndrome", "histiocytosis", "X", "Papillon-Lefevre", "syndrome", ",", "permanent", "teeth", "discolouration", "to", "tetracyclines", ",", "Vitamin", "D-dependent", "vitamin", "D-resistant", "rickets"], "h": {"id": "C0162530", "name": "C0162530#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221023", "name": "C0221023#ent", "pos": [17, 18]}}
{"token": ["The", "three", "midline", "malformation", "complexes", ",", "the", "oral-facial-digital", "syndrome", "type", "VI", "OFDS", "VI", "or", "C0039082#ent", "<e1>", "the", "hydrolethalus", "syndrome", "HS", ")", ",", "and", "the", "C0265220#ent", "<e2>", "PHS", ")", "have", "been", "described", "as", "distinct", "genetic", "entities", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0265220", "name": "C0265220#ent", "pos": [24, 25]}}
{"token": ["The", "three", "midline", "malformation", "complexes", ",", "the", "oral-facial-digital", "syndrome", "type", "VI", "OFDS", "VI", "or", "C0039082#ent", "<e1>", "the", "hydrolethalus", "syndrome", "HS", ")", ",", "and", "the", "Pallister-Hall", "syndrome", "C0265220#ent", "<e2>", ")", "have", "been", "described", "as", "distinct", "genetic", "entities", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0265220", "name": "C0265220#ent", "pos": [26, 27]}}
{"token": ["C0304497#ent", "<e1>", "streptozocin", ",", "5-fluorouracil", "and", "C0085752#ent", "<e2>", ")", "were", "able", "to", "alleviate", "clinical", "symptoms", "to", "control", "tumor", "growth", "six", "years", "."], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [6, 7]}}
{"token": ["The", "most", "C0304497#ent", "<e1>", "tested", "were", "methotrexate", ",", "mitoxantrone", ",", "C0085752#ent", "<e2>", ",", "mitomycin", "C", "cisplatin", "."], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [10, 11]}}
{"token": ["We", "found", "that", "lysine", "204", "of", "Galpha13", "is", "important", "for", "interaction", "with", "the", "RGS", "domain", "C1864009#ent", "<e1>", "or", "LARG", "and", "for", "the", "GTPase-activating", "protein", "of", "these", "C0086376#ent", "<e2>", "."], "h": {"id": "C1864009", "name": "C1864009#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [26, 27]}}
{"token": ["We", "have", "previously", "shown", "that", "p115", ",", "a", "C1864009#ent", "<e1>", "binds", "to", "two", "C0086376#ent", "<e2>", "(", "p130", "and", "p400", ")", "in", "detergent", "extracts", "Golgi", "membranes"], "h": {"id": "C1864009", "name": "C1864009#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["Befloxatone", ",", "a", "selective", "reversible", "C0026457#ent", "<e1>", "N-acetylserotonin", "and", "melatonin", "decreased", "the", "C2926735#ent", "<e2>", "of", "immobility", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [12, 13]}}
{"token": ["This", "study", "demonstrates", "that", "the", "inverted", "circadian", "blood", "pressure", "profile", "affected", "only", "slightly", "the", "circadian", "rhythms", "in", "kidney", "function", "C1427067#ent", "<e1>", "compared", "with", "C1420565#ent", "<e2>", "."], "h": {"id": "C1427067", "name": "C1427067#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420565", "name": "C1420565#ent", "pos": [23, 24]}}
{"token": ["PAPA", "syndrome", "pyogenic", "sterile", "arthritis", "C0085652#ent", "<e1>", "and", "acne", ",", "OMIM", "#", "604416", ")", "and", "C1858361#ent", "<e2>", "FRA", ")", "are", "rare", "inherited", "disorders", "early", "onset", "primarily", "affecting", "skin", "and", "joint", "tissues"], "h": {"id": "C0085652", "name": "C0085652#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C1858361", "name": "C1858361#ent", "pos": [15, 16]}}
{"token": ["PAPA", "syndrome", "pyogenic", "sterile", "arthritis", "C0085652#ent", "<e1>", "and", "acne", ",", "OMIM", "#", "604416", ")", "and", "familial", "recurrent", "arthritis", "C1858361#ent", "<e2>", ")", "are", "rare", "inherited", "disorders", "early", "onset", "primarily", "affecting", "skin", "and", "joint", "tissues"], "h": {"id": "C0085652", "name": "C0085652#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C1858361", "name": "C1858361#ent", "pos": [18, 19]}}
{"token": ["The", "risk", "of", "C0010068#ent", "<e1>", "CHD", ")", "is", "increased", "in", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [10, 11]}}
{"token": ["Treatment", "of", "deltaMEKI", ":", "ER-responsive", "cells", "with", "a", "specific", "and", "selective", "inhibitor", ",", "C0298346#ent", "<e1>", ",", "prevented", "growth", "in", "response", "to", "C0014914#ent", "<e2>", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014914", "name": "C0014914#ent", "pos": [21, 22]}}
{"token": ["The", "C4042483#ent", "<e1>", "suppresses", "apoptosis", "and", ",", "when", "C3889446#ent", "<e2>", "in", "prostate", "cancer", ",", "makes", "these", "cells", "resistant", "to", "a", "variety", "of", "therapeutic", "agents", "including", "hormonal", "ablation"], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [8, 9]}}
{"token": ["The", "C0033679#ent", "<e1>", "induced", "by", "C0142812#ent", "<e2>", "to", "be", "tissue", "transglutaminase", "based", "on", "its", "cytosolic", "localization", "thermal", "lability", "basic", "pH", ",", "and", "elution", "profile", "on", "anion-exchange", "chromatography"], "h": {"id": "C0033679", "name": "C0033679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0142812", "name": "C0142812#ent", "pos": [5, 6]}}
{"token": ["Cyclooxygenase-2", "(", "C1565860#ent", "<e1>", ")", "plays", "a", "key", "role", "in", "human", "inflammatory", "disorders", "as", "C0947751#ent", "<e2>"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0947751", "name": "C0947751#ent", "pos": [14, 15]}}
{"token": ["The", "overexpression", "of", "C1565860#ent", "<e1>", "Cox-2", ")", "has", "been", "associated", "with", "C0947751#ent", "<e2>", "cellular", "proliferation"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0947751", "name": "C0947751#ent", "pos": [11, 12]}}
{"token": ["The", "inducible", "cyclooxygenase", "C1565860#ent", "<e1>", ",", "has", "been", "associated", "with", "C0947751#ent", "<e2>", "cellular", "proliferation"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0947751", "name": "C0947751#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "BP", "on", "the", "drug-metabolizing", "C3540017#ent", "<e1>", "and", "fine", "structure", "the", "liver", "was", "similar", "to", "that", "of", "C0068468#ent", "<e2>", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0068468", "name": "C0068468#ent", "pos": [19, 20]}}
{"token": ["We", "find", "that", "kinetics", "for", "D2", "degradation", "mirror", "those", "for", "C3889128#ent", "<e1>", ",", "except", "that", "the", "actual", "half-life", "times", "of", "the", "C1538717#ent", "<e2>", "about", "three", "times", "larger", "than", "those", "of", "the", "C3889128#ent", "<e1>", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1538717", "name": "C1538717#ent", "pos": [21, 22]}}
{"token": ["Both", "tyrosines", "are", "proposed", "to", "form", "hydrogen", "bonds", "nearby", "histidine", "residues", "(", "for", "Synechocystis", "6803", "these", "are", "His190", "on", "the", "C3889128#ent", "<e1>", "and", "His189", "on", "the", "C1538717#ent", "<e2>", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1538717", "name": "C1538717#ent", "pos": [26, 27]}}
{"token": ["Since", "ultrasonography", "is", "a", "non-invasive", ",", "east-to-perform", "procedure", ",", "ultrasonographic", "measurement", "of", "the", "C1419846#ent", "<e1>", "seems", "to", "be", "useful", "in", "the", "diagnosis", "of", "C1335836#ent", "<e2>", "."], "h": {"id": "C1419846", "name": "C1419846#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335836", "name": "C1335836#ent", "pos": [23, 24]}}
{"token": ["Recently", "prokineticin", "1", "C4085189#ent", "<e1>", ")", "was", "identified", "as", "a", "C0026249#ent", "<e2>", "of", "fenestrated", "endothelium"], "h": {"id": "C4085189", "name": "C4085189#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [10, 11]}}
{"token": ["GPIIb/IIIa", "inhibitors", "abciximab", "and", "C0253563#ent", "<e1>", "have", "been", "shown", "to", "inhibit", "platelet", "aggregation", "C0151744#ent", "<e2>"], "h": {"id": "C0253563", "name": "C0253563#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [13, 14]}}
{"token": ["Preadsorption", "of", "the", "C0008312#ent", "<e1>", "sera", "with", "C0034861#ent", "<e2>", "abolished", "their", "reactivity", "with", "the", "antigen", "."], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [7, 8]}}
{"token": ["Here", ",", "we", "show", "that", "Ser31", "is", "phosphorylated", "by", "C1366765#ent", "<e1>", "and", "ERK2", ",", "two", "myelin", "basic", "protein", "C0769224#ent", "<e2>"], "h": {"id": "C1366765", "name": "C1366765#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0769224", "name": "C0769224#ent", "pos": [18, 19]}}
{"token": ["We", "have", "studied", "the", "molecular", "function", "proteolipid", "protein", "C1705623#ent", "<e1>", ")", ",", "the", "main", "C0021699#ent", "<e2>", "CNS", "myelin", ",", "by", "generating", "mice", "lacking", "C1705623#ent", "<e1>", "expression", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705623", "name": "C1705623#ent", "pos": [8, 9]}}
{"token": ["In", "experiments", "designed", "to", "elucidate", "the", "role", "of", "divalent", "cations", "maintaining", "the", "integrity", "of", "the", "epidermis", ",", "newborn", "mouse", "skin", "incubated", "in", "C0013618#ent", "<e1>", "EDTA", ")", "or", "C0013618#ent", "<e1>", "EGTA", ")", "."], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [22, 23]}}
{"token": ["A", "young", ",", "former", "homosexual", "and", "narcotics-abusing", "male", "patient", "developed", "C0231218#ent", "<e1>", ",", "fever", ",", "lymphadenopathy", ",", "C0239295#ent", "<e2>", "lymphopenia", ",", "and", "anergy", "progressing", "to", "severe", "odynophagia", "and", "a", "weight", "loss", "60", "lb", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0239295", "name": "C0239295#ent", "pos": [17, 18]}}
{"token": ["Assignment", "of", "the", "disease", "genes", "the", "same", "region", "of", "the", "long", "arm", "of", "14", "in", "both", "SCA3", "and", "C0024408#ent", "<e1>", "suggested", "that", "these", "two", "disorders", "are", "C1516876#ent", "<e2>", "identical", "."], "h": {"id": "C0024408", "name": "C0024408#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [26, 27]}}
{"token": ["In", "contrast", ",", "the", "interaction", "of", "C3540626#ent", "<e1>", "with", "the", "C1412616#ent", "<e2>", "mRNA", "is", "decreased", "in", "histidine-deprived", "cells", "relative", "to", "control", "cells"], "h": {"id": "C3540626", "name": "C3540626#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412616", "name": "C1412616#ent", "pos": [10, 11]}}
{"token": ["C0442874#ent", "<e1>", "developed", "in", "three", "patients", "with", "C0007570#ent", "<e2>", "a", "long", "time", "they", "had", "been", "cured", "of", "their", "digestive", "disease", "following", "a", "gluten-free", "diet"], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [7, 8]}}
{"token": ["Functional", "analysis", "the", "C3275256#ent", "<e1>", "promoter", "demonstrates", "that", "C1414316#ent", "<e2>", "Egr-1", ")", "is", "an", "important", "transcriptional", "regulator", "C3275256#ent", "<e1>", "."], "h": {"id": "C1414316", "name": "C1414316#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3275256", "name": "C3275256#ent", "pos": [3, 4]}}
{"token": ["We", "measured", "cyclic", "C4285220#ent", "<e1>", "generation", "by", "leukocytes", "in", "response", "to", "the", "C3536829#ent", "<e2>", "isoproterenol", "and", "to", "prostaglandin", "E1", "PGE1", ")", "in", "six", "patients", "with", "Bartter's", "syndrome"], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536829", "name": "C3536829#ent", "pos": [12, 13]}}
{"token": ["By", "cross-linking", "surface", "Ig", "to", "the", "Fc", "gamma", "R", "whole", "(IgG)-rabbit", "anti-Ig", "antibodies", "been", "shown", "to", "substantially", "inhibit", "proliferation", "induced", "by", "C2697656#ent", "<e1>", "and", "F(ab')2", "anti-Ig", ",", "and", "C0259479#ent", "<e2>", "induced", "by", "F(ab')2", "anti-Ig", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0259479", "name": "C0259479#ent", "pos": [28, 29]}}
{"token": ["The", "rate", "of", "GFR", "decline", "(", "Delta", "GFR", "and", "the", "incidence", "of", "C2316810#ent", "<e1>", "ESRD", ")", "during", "C0072973#ent", "<e2>", "or", "non-ACE", "inhibitor", "treatment", "were", "compared", "within", "three", "tertiles", "of", "basal", "GFR", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0072973", "name": "C0072973#ent", "pos": [17, 18]}}
{"token": ["C0040149#ent", "<e1>", "SAT", ")", ",", "or", "granulomatous", "thyroiditis", "is", "an", "C0040147#ent", "<e2>", "associated", "with", "pain", "and", "systemic", "symptoms"], "h": {"id": "C0040149", "name": "C0040149#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0040147", "name": "C0040147#ent", "pos": [10, 11]}}
{"token": ["A", "43-year-old", "healthy", "man", "developed", "transmural", "myocardial", "infarction", "after", "ingesting", "C0206599#ent", "<e1>", "mg", "for", "C0149931#ent", "<e2>", "."], "h": {"id": "C0206599", "name": "C0206599#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [14, 15]}}
{"token": ["However", ",", "recent", "studies", "in", "this", "laboratory", "showed", "that", "C3887686#ent", "<e1>", ",", "and", "not", "C1257646#ent", "<e2>", ",", "is", "the", "primary", "enzyme", "responsible", "for", "urethane", "oxidation"], "h": {"id": "C3887686", "name": "C3887686#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [14, 15]}}
{"token": ["Our", "previous", "observations", "and", "these", "results", "suggest", "that", "vitamin", "A", "a", "photo-signal", "are", "required", "to", "maintain", "the", "rhythmic", "expression", "of", "the", "C1135159#ent", "<e1>", "well", "as", "the", "C0036755#ent", "<e2>"], "h": {"id": "C1135159", "name": "C1135159#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0036755", "name": "C0036755#ent", "pos": [26, 27]}}
{"token": ["Fumarase", ",", "aconitase", ",", "catalase", ",", "citritase", ",", "C0034348#ent", "<e1>", "enolase", ",", "phosphoenolpyruvate", "carboxylase", "lactic", "dehydrogenase", "alpha-ketoglutarate", "dehydrogenase", "and", "C0024545#ent", "<e2>", "not", "detectable", "in", "crude", "extracts", "Beggiatoa", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024545", "name": "C0024545#ent", "pos": [19, 20]}}
{"token": ["In", "addition", "to", "the", "CYP3A4", "inhibitors", "ketoconazole", ",", "fluconazole", ",", "indinavir", ",", "ritonavir", ",", "and", "C0286737#ent", "<e1>", ",", "metyrapone", "strongly", "inhibited", "C1412390#ent", "<e2>", "formation", "."], "h": {"id": "C0286737", "name": "C0286737#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412390", "name": "C1412390#ent", "pos": [21, 22]}}
{"token": ["The", "expression", "of", "C1335591#ent", "<e1>", "was", "significantly", "higher", "in", "the", "C0144576#ent", "<e2>", "(", "2008/13/4", "and", "2008/17/4", ")", "cells", "than", "in", "the", "parental", "(", "2008", ")", "cells", "."], "h": {"id": "C1335591", "name": "C1335591#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0144576", "name": "C0144576#ent", "pos": [10, 11]}}
{"token": ["Mutants", "of", "C1419150#ent", "<e1>", "that", "fail", "to", "associate", "with", "C0812252#ent", "<e2>", "or", "GIT2", ",", "or", "do", "not", "target", "to", "focal", "adhesions", "inhibit", "Crk-dependent", "cell", "spreading", "and", "lamellipodia", "formation", "."], "h": {"id": "C1419150", "name": "C1419150#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "stimulation", "of", "motility", "by", "collagen", "preferentially", "enhanced", "the", "association", "of", "C1419150#ent", "<e1>", "with", "the", "SH2", "domain", "the", "adaptor", "protein", "C0812252#ent", "<e2>", "."], "h": {"id": "C1419150", "name": "C1419150#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [21, 22]}}
{"token": ["Phosphorylation", "of", "C1419150#ent", "<e1>", "on", "tyrosine", "creates", "binding", "sites", "the", "SH2", "domains", "C0812252#ent", "<e2>", ",", "Csk", ",", "and", "Src", "."], "h": {"id": "C1419150", "name": "C1419150#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [12, 13]}}
{"token": ["Platelet", "reactivity", "tested", "in", "vitro", "platelet", "rich", "plasma", "the", "aggregability", "towards", "ADP", "1", "microM", "and", "C0009325#ent", "<e1>", "as", "the", "sensitivity", "to", "C0205911#ent", "<e2>", "(", "PSP", ")", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [21, 22]}}
{"token": ["As", "an", "inhibitor", "of", "platelet", "aggregation", "induced", "by", "ADP", "or", "C0009325#ent", "<e1>", "in", "vitro", "carbacyclin", "is", "0.03", "times", "as", "active", "as", "C0205911#ent", "<e2>", "in", "human", ",", "dog", "or", "rabbit", "plasma", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [21, 22]}}
{"token": ["In", "this", "model", ",", "neither", "the", "passage", "of", "platelets", "alone", "nor", "C0009325#ent", "<e1>", "alone", "stimulated", "C0205911#ent", "<e2>", "(", "PGI2", ")", "production", "by", "the", "HUVECs", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [15, 16]}}
{"token": ["Similarly", ",", "pretreatment", "with", "LY379268", "was", "able", "to", "reverse", "the", "C0268528#ent", "<e1>", "induced", "with", "the", "catecholamine", "synthesis", "inhibitor", ",", "alpha-methyl-p-tyrosine", "(", "C0051427#ent", "<e2>", ")", "."], "h": {"id": "C0268528", "name": "C0268528#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0051427", "name": "C0051427#ent", "pos": [21, 22]}}
{"token": ["Participation", "of", "C1413857#ent", "<e1>", "and", "REN", "and", "possibly", "C1706480#ent", "<e2>", "development", "of", "low", "renin", "AH", "was", "convincingly", "shown", "."], "h": {"id": "C1413857", "name": "C1413857#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706480", "name": "C1706480#ent", "pos": [8, 9]}}
{"token": ["These", "results", "demonstrate", "that", "C1705504#ent", "<e1>", "has", "an", "influence", "on", "IL-8", "and", "C1565830#ent", "<e2>", "protein", "expression", "least", "in", "part", "through", "PPAR-gamma", "."], "h": {"id": "C1705504", "name": "C1705504#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [12, 13]}}
{"token": ["The", "genomic", "organization", "similar", "to", "that", "of", "other", "papillomaviruses", ",", "with", "open", "reading", "frames", ",", "E7", ",", "E1", ",", "E2", ",", "and", "C3272385#ent", "<e1>", "in", "the", "early", "and", "C3538854#ent", "<e2>", "and", "L1", "in", "the", "late", "region"], "h": {"id": "C3272385", "name": "C3272385#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3538854", "name": "C3538854#ent", "pos": [28, 29]}}
{"token": ["The", "content", "of", "the", "main", "glucose", "transporters", "muscle", ",", "GLUT-4", "and", "GLUT-1", ",", "was", "not", "affected", "by", "C0162429#ent", "<e1>", ",", "but", "fractionation", "studies", "an", "improved", "C4082284#ent", "<e2>", "GLUT-4", "translocation", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [25, 26]}}
{"token": ["C0342482#ent", "<e1>", "CAH", ")", "and", "glycerol", "kinase", "deficiency", "C2700225#ent", "<e2>", ")", "were", "diagnosed", "in", "a", "male", "during", "the", "neonatal", "period", "."], "h": {"id": "C0342482", "name": "C0342482#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2700225", "name": "C2700225#ent", "pos": [8, 9]}}
{"token": ["Although", "the", "amounts", "of", "C1333342#ent", "<e1>", "of", "bone", "marrow", "cells", "patients", "with", "refractory", "anemia", "C0003873#ent", "<e2>", ")", "were", "less", "than", "those", "of", "normal", "bone", "marrow", "cells", "all", "phenotypes", "examined", ",", "there", "was", "no", "statistical", "significant", "."], "h": {"id": "C1333342", "name": "C1333342#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["Second", ",", "we", "observed", "that", "Drosophila", "C0085292#ent", "<e1>", "behaved", "like", "integral", "membrane", "proteins", "C0146953#ent", "<e2>", "partitioning", "experiments"], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0146953", "name": "C0146953#ent", "pos": [13, 14]}}
{"token": ["The", "restriction", "map", "constructed", "for", "plasmid", "C1456391#ent", "<e1>", "having", "the", "cleavage", "sites", "Sau3a", ",", "HincII", ",", "HindIII", ",", "C0012906#ent", "<e2>"], "h": {"id": "C1456391", "name": "C1456391#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [18, 19]}}
{"token": ["C3538973#ent", "<e1>", "AID", ")", "and", "C1421361#ent", "<e2>", "UNG", ")", "are", "required", "for", "class", "switch", "recombination", "CSR", ")", "."], "h": {"id": "C3538973", "name": "C3538973#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421361", "name": "C1421361#ent", "pos": [5, 6]}}
{"token": ["These", "data", "indicated", "that", "C0538927#ent", "<e1>", "increased", "superoxide", "anion", "by", "increasing", "intracellular", "calcium", "and", "C1259877#ent", "<e2>", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [14, 15]}}
{"token": ["Amoxicillin", "PULSYS", "is", "in", "clinical", "development", "the", "treatment", "of", "pharyngitis", "and/or", "C0040425#ent", "<e1>", "due", "to", "group", "A", "C0038395#ent", "<e2>", "adolescents/adults", "as", "a", "tablet", "formulation"], "h": {"id": "C0040425", "name": "C0040425#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0038395", "name": "C0038395#ent", "pos": [17, 18]}}
{"token": ["Clinical", "study", "Clinical", "studies", "MK-0787/MK-0791", "were", "carried", "out", "in", "6", "pediatric", "patients", ";", "1", "each", "with", "femoral", "cellulitis", "sepsis", "suspected", ",", "salmonellosis", ",", "C0040425#ent", "<e1>", "bronchopneumonia", "and", "C0038395#ent", "<e2>", "."], "h": {"id": "C0040425", "name": "C0040425#ent", "pos": [23, 24]}, "relation": "related_to", "t": {"id": "C0038395", "name": "C0038395#ent", "pos": [27, 28]}}
{"token": ["Seventy-four", "patients", "with", "recent", "C0038525#ent", "<e1>", "randomly", "allocated", "to", "placebo", "or", "C0040613#ent", "<e2>", "treatment", "."], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0040613", "name": "C0040613#ent", "pos": [11, 12]}}
{"token": ["The", "efficacy", "of", "the", "C0035339#ent", "<e1>", "in", "preventing", "C1706331#ent", "<e2>", "release", "paralleled", "their", "activity", "in", "inhibiting", "phorbol", "ester-induced", "OrnDCase", "activity", "and", "skin", "tumor", ",", "as", "reported", "in", "the", "literature", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [8, 9]}}
{"token": ["The", "tissue", "origin", "C0024031#ent", "<e1>", "LBP", ")", "or", "referred", "lower", "extremity", "symptoms", "C1414864#ent", "<e2>", ")", "may", "be", "identified", "in", "about", "70", "%", "of", "cases", "using", "advanced", "imaging", "discography", "and", "facet", "or", "sacroiliac", "joint", "blocks"], "h": {"id": "C0024031", "name": "C0024031#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414864", "name": "C1414864#ent", "pos": [12, 13]}}
{"token": ["Chimeric", "transcripts", "expressed", "by", "these", "cells", "contain", "5", "'", "NPM", "coding", "sequences", "in-frame", "to", "those", "of", "the", "new", "C0017337#ent", "<e1>", ",", "which", "we", "named", "C1417188#ent", "<e2>", "MLF1", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417188", "name": "C1417188#ent", "pos": [24, 25]}}
{"token": ["Some", "C0017337#ent", "<e1>", ",", "such", "as", "BaRF1", ",", "C1417188#ent", "<e2>", ",", "and", "a", "late", "gene", "BLRF2", ",", "are", "maximally", "activated", "by", "Rta", "itself", "in", "the", "absence", "of", "detectable", "ZEBRA", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417188", "name": "C1417188#ent", "pos": [8, 9]}}
{"token": ["Non-scarring", "alopecias", "(", "diffuse", "alopecia", "C0162311#ent", "<e1>", "alopecia", "areata", "are", "essentially", "C0018500#ent", "<e2>", "while", "scarring", "alopecias", "result", "from", "irreversible", "destruction", "of", "the", "hair", "follicles", "recognizable", "loss", "of", "follicular", "osita", "."], "h": {"id": "C0162311", "name": "C0162311#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018500", "name": "C0018500#ent", "pos": [11, 12]}}
{"token": ["Cystic", "fibrosis", "CF", ")", "is", "the", "most", "common", "C3899988#ent", "<e1>", "Caucasian", "population", "that", "involves", "the", "lungs", ",", "C0771711#ent", "<e2>", ",", "sweat", "glands", "intestine", ",", "liver", "and", "reproductive", "tract"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [17, 18]}}
{"token": ["Hereditary", "aceruloplasminemia", "is", "an", "adult-onset", "C3899988#ent", "<e1>", "by", "increased", "iron", "overload", "the", "liver", ",", "C0771711#ent", "<e2>", ",", "retina", ",", "and", "central", "nervous", "system"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [14, 15]}}
{"token": ["Cystic", "fibrosis", "an", "C3899988#ent", "<e1>", "affecting", "the", "lungs", ",", "C0771711#ent", "<e2>", ",", "intestines", ",", "sweat", "ducts", "liver", ",", "due", "to", "an", "abnormal", "salt", "transport", "the", "apical", "border", "epithelial", "cells"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [9, 10]}}
{"token": ["Uncoupling", "protein", "C3810625#ent", "<e1>", ")", "2", "and", "UCP3", "are", "newly", "discovered", "C0086376#ent", "<e2>", "that", "can", "uncouple", "ATP", "production", "from", "mitochondrial", "respiration", "thereby", "dissipating", "energy", "as", "heat", "and", "affecting", "energy", "metabolism", "efficiency", "."], "h": {"id": "C3810625", "name": "C3810625#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Photolabeling", "of", "mitochondria", "with", "[3H]AzDA", "resulted", "in", "a", "prominent", "32", "kDa", "band", "of", "C3810625#ent", "<e1>", ",", "and", "few", "other", "C0086376#ent", "<e2>", "were", "labeled", "."], "h": {"id": "C3810625", "name": "C3810625#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "C0175697#ent", "<e1>", "blocks", "plasticity-associated", "changes", "in", "nerve", "growth", "factor", "expression", ",", "C0919487#ent", "<e2>", "activation", "and", "extracellular", "signal-regulated", "kinase", "activation"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0919487", "name": "C0919487#ent", "pos": [14, 15]}}
{"token": ["Norepinephrine", "(", "NE", ")", ",", "a", "key", "C0243051#ent", "<e1>", "of", "the", "central", "and", "peripheral", "nervous", "systems", "is", "synthesized", "by", "C0013032#ent", "<e2>", "DBH", ")", "that", "catalyzes", "oxidation", "of", "dopamine", "(", "DA", ")", "to", "NE", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013032", "name": "C0013032#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", ",", "we", "sought", "to", "determine", "if", "an", "immunotoxin", "targeted", "at", "the", "C0243051#ent", "<e1>", "synthesizing", "enzyme", ",", "C0013032#ent", "<e2>", "DBH", ")", ",", "could", "selectively", "destroy", "central", "noradrenergic", "neurons", "intraventricular", "administration"], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013032", "name": "C0013032#ent", "pos": [20, 21]}}
{"token": ["Antibodies", "to", "PSMA4", "(", "C1413029#ent", "<e1>", ")", "immunoprecipitated", "complexes", "composed", "of", "alpha", ",", "precursor", "beta", "processed", "C0599220#ent", "<e2>"], "h": {"id": "C1413029", "name": "C1413029#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}}
{"token": ["Membrane", "attack", "complement", "involves", "the", "self-assembly", "on", "membranes", "of", "five", "hydrophilic", "proteins", "C5b", ",", "C6", ",", "C7", ",", "C8", "and", "C1413029#ent", "<e1>", ")", "to", "an", "amphiphilic", "tubular", "complex", "approximately", "20", "C0599220#ent", "<e2>", "."], "h": {"id": "C1413029", "name": "C1413029#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [30, 31]}}
{"token": ["Hourly", "C3714642#ent", "<e1>", "and", "chloride", "losses", "were", "significantly", "lower", "following", "C0006376#ent", "<e2>", "than", "furosemide", "during", "the", "first", "two", "8-h", "periods", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006376", "name": "C0006376#ent", "pos": [10, 11]}}
{"token": ["If", "KCl", "was", "stepwise", "replaced", "by", "choline", "chloride", "C3714642#ent", "<e1>", "uptake", "decreased", "in", "the", "absence", "of", "C0006376#ent", "<e2>", "but", "was", "only", "insignificantly", "altered", "in", "the", "presence", "of", "C0006376#ent", "<e2>", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006376", "name": "C0006376#ent", "pos": [16, 17]}}
{"token": ["In", "the", "presence", "of", "chloride", ",", "C3714642#ent", "<e1>", "uptake", "was", "inhibited", "56", "%", "by", "0.4", "mM", "C0006376#ent", "<e2>", "and", "40", "%", "by", "0.8", "mM", "N-methylfurosemide", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006376", "name": "C0006376#ent", "pos": [16, 17]}}
{"token": ["Immunohistochemical", "staining", "C0023351#ent", "<e1>", "and", "lepromatous", "leprosy", "C0037284#ent", "<e2>", "performed", "using", "various", "rabbit", "antisera", "."], "h": {"id": "C0023351", "name": "C0023351#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [7, 8]}}
{"token": ["Besides", ",", "pretreatment", "of", "A-431", "cells", "with", "C0028247#ent", "<e1>", "resulted", "in", "decreasing", "tyrosine", "phosphorylation", "some", "C0086376#ent", "<e2>", "."], "h": {"id": "C0028247", "name": "C0028247#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["The", "role", "of", "C0041484#ent", "<e1>", "and", "peroxidase", "in", "melanogenesis", "of", "5-hydroxytryptamine", ",", "5,6-", "and", "C0000544#ent", "<e2>", "was", "investigated", "by", "matrix-assisted", "laser", "desorption/ionization", "mass", "spectrometry"], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000544", "name": "C0000544#ent", "pos": [14, 15]}}
{"token": ["C1504688#ent", "<e1>", "appears", "to", "determine", "severity", "of", "C0030305#ent", "<e2>", "susceptibility", "to", "idiopathic", "acute", "pancreatitis"], "h": {"id": "C1504688", "name": "C1504688#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [7, 8]}}
{"token": ["Anaplastic", "large", "cell", "lymphomas", "ALCL", ")", "are", "characterized", "by", "the", "expression", "of", "a", "chimeric", "protein", "C0541106#ent", "<e1>", ",", "which", "originates", "from", "fusion", "of", "the", "C1334894#ent", "<e2>", "(", "NPM", ")", "and", "the", "membrane", "receptor", "anaplastic", "lymphoma", "kinase", "ALK", ")", "genes", "."], "h": {"id": "C0541106", "name": "C0541106#ent", "pos": [15, 16]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1334894", "name": "C1334894#ent", "pos": [24, 25]}}
{"token": ["Block", "of", "Ca2", "+", "channel", "current", "by", "C0012315#ent", "<e1>", "and", "by", "C0211011#ent", "<e2>", "(", "omega-CgTx", ")", "was", "studied", "in", "a", "variety", "of", "freshly", "dissociated", "rat", "neurons", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0211011", "name": "C0211011#ent", "pos": [11, 12]}}
{"token": ["IBa", "was", "sensitive", "to", "C0012315#ent", "<e1>", "and", "insensitive", "to", "the", "peptide", "toxins", "omega-agatoxin", "IVa", "C0211011#ent", "<e2>", "GVIa", ",", "and", "omega-conotoxin", "MVIIC"], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0211011", "name": "C0211011#ent", "pos": [14, 15]}}
{"token": ["Despite", "continued", "C1424250#ent", "<e1>", "infusion", ",", "addition", "of", "C0280858#ent", "<e2>", "led", "to", "return", "of", "for", "PGC", ",", "QA", ",", "Kf", ",", "RA", ",", "and", "RE", "essentially", "to", "pre-AII", "levels", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [8, 9]}}
{"token": ["The", "activities", "of", "DA", "and", "C0701351#ent", "<e1>", "are", "not", "entirely", "the", "same", "as", "that", "of", "C1419249#ent", "<e2>", "."], "h": {"id": "C0701351", "name": "C0701351#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419249", "name": "C1419249#ent", "pos": [15, 16]}}
{"token": ["Two", "paralogous", "haemoglobin", "genes", "glob1", "and", "C1420852#ent", "<e1>", ")", "from", "the", "C0024530#ent", "<e2>", "mosquito", "Anopheles", "gambiae", "cloned", "and", "sequenced", "."], "h": {"id": "C1420852", "name": "C1420852#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}}
{"token": ["Treatment", "of", "amiodarone-induced", "thyrotoxicosis", "C4049878#ent", "<e1>", ")", "with", "thionamide", ",", "C3540800#ent", "<e2>", "or", "radioactive", "iodine", "ineffective", "."], "h": {"id": "C4049878", "name": "C4049878#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540800", "name": "C3540800#ent", "pos": [10, 11]}}
{"token": ["C0017718#ent", "<e1>", "has", "also", "been", "used", "to", "prevent", "and", "treat", "C0029408#ent", "<e2>", "in", "animals", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [10, 11]}}
{"token": ["The", "high", "incidence", "of", "middle-ear", "dysfunction", "and", "the", "associated", "C0018777#ent", "<e1>", "and", "the", "progressive", "sensorineural", "loss", "found", "in", "C0013080#ent", "<e2>", "discussed", "."], "h": {"id": "C0018777", "name": "C0018777#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0013080", "name": "C0013080#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "the", "efficacy", "of", "C0008809#ent", "<e1>", "as", "an", "empirical", "treatment", "fever", "in", "97", "C0027947#ent", "<e2>", "patients", "in", "a", "randomized", "study", "C0008809#ent", "<e1>", "and", "benzylpenicillin", "versus", "netilmicin", "and", "piperacillin", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [5, 6]}}
{"token": ["Low-risk", "febrile", "C0027947#ent", "<e1>", "patients", "can", "receive", "oral", "C0008809#ent", "<e2>", "or", "levofloxacin", ",", "with", "or", "without", "amoxicillin/clavulanic", "acid", "on", "an", "outpatient", "basis", ",", "or", "intravenous", "(", "i.v", ".", ")"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [8, 9]}}
{"token": ["Two-color", "analysis", "revealed", "that", "neo-CRPbright", "cells", "co-expressed", "CD19", ",", "C1706319#ent", "<e1>", ",", "and", "HLA-DR", ",", "whereas", "neo-CRPdim", "cells", "co-expressed", "C1414556#ent", "<e2>", ",", "CD11b", ",", "Leu-7", ",", "and", "Leu-19", "."], "h": {"id": "C1706319", "name": "C1706319#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414556", "name": "C1414556#ent", "pos": [19, 20]}}
{"token": ["In", "this", "article", "we", "show", "that", "C1332729#ent", "<e1>", "induces", "expression", "of", "C1333659#ent", "<e2>", "Gas1", ")", ",", "an", "integral", "membrane", "protein", "up-regulated", "in", "nonproliferating", "cells", "."], "h": {"id": "C1332729", "name": "C1332729#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333659", "name": "C1333659#ent", "pos": [11, 12]}}
{"token": ["In", "spite", "of", "the", "apparently", "random", "genetic", "basis", "of", "the", "C1951340#ent", "<e1>", "of", "antigenic", "variation", "the", "C0242723#ent", "<e2>", "characterized", "by", "an", "as", "yet", "unexplained", "order", "of", "appearance", "of", "major", "VSG", "variants", "."], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242723", "name": "C0242723#ent", "pos": [16, 17]}}
{"token": ["The", "interaction", "between", "protein", "kinase", "CK2", "C0032518#ent", "<e1>", "has", "been", "studied", "by", "Surface", "Plasmon", "Resonance", "C1420565#ent", "<e2>", ")", "."], "h": {"id": "C0032518", "name": "C0032518#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420565", "name": "C1420565#ent", "pos": [15, 16]}}
{"token": ["In", "1977", "we", "undertook", "a", "prospective", "study", "at", "evaluating", "the", "preventive", "effects", "a", "retinoid", "(", "C0015137#ent", "<e1>", ",", "Roche", ")", "on", "the", "occurrence", "of", "skin", "carcinomas", "C0018567#ent", "<e2>", "carrying", "a", "high", "risk", "malignancy", "."], "h": {"id": "C0015137", "name": "C0015137#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018567", "name": "C0018567#ent", "pos": [26, 27]}}
{"token": ["C0349782#ent", "<e1>", "the", "myocardial", "dysfunction", "by", "C0010068#ent", "<e2>"], "h": {"id": "C0349782", "name": "C0349782#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [6, 7]}}
{"token": ["Meconium-induced", "airway", "hyperreactivity", "to", "histamine", "and", "C0032285#ent", "<e1>", "alleviated", "by", "C0011777#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}}
{"token": ["Complications", ",", "including", "C0032285#ent", "<e1>", "and", "gastrointestinal", "bleeding", "occurred", "in", "26", "patients", "given", "C0011777#ent", "<e2>", "and", "11", "given", "placebo", "(", "P", "=", "0.004", ")", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [13, 14]}}
{"token": ["In", "human", "beings", ",", "deficiency", "of", "these", "C0031727#ent", "<e1>", "leads", "to", "hereditary", "diseases", "namely", "C3711796#ent", "<e2>", "AT", ")", "with", "ATM", "deficiency", "ATR-Seckel", "with", "ATR", "deficiency"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3711796", "name": "C3711796#ent", "pos": [14, 15]}}
{"token": ["Inhibitors", "such", "as", "C0031493#ent", "<e1>", "Streptomyces", "subtilisin", "inhibitor", "did", "not", "block", "the", "processing", "of", "C2987364#ent", "<e2>", "pro-subtilisin", "."], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [14, 15]}}
{"token": ["Taken", "together", ",", "these", "data", "indicate", "that", "vitamin", "D", "compounds", "induce", "apoptosis", "via", "a", "novel", "C0534519#ent", "<e1>", "and", "p53-independent", "pathway", "that", "can", "be", "inhibited", "by", "C0376515#ent", "<e2>", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [25, 26]}}
{"token": ["Moreover", ",", "cDNA", "array", "analysis", "gene", "expression", "that", "treatment", "with", "E2", "upregulated", "several", "genes", "involved", "in", "apoptosis", ",", "including", "FasL", ",", "C0534519#ent", "<e1>", ",", "TRAIL", ",", "and", "iNOS", ",", "but", "not", "C0376515#ent", "<e2>"], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [31, 32]}}
{"token": ["We", "concluded", "that", "combined", "activation", "of", "the", "C0534519#ent", "<e1>", "and", "down-regulation", "of", "C0376515#ent", "<e2>", "could", "determine", "the", "fate", "of", "B-cell", "leukaemic", "cells", "in", "response", "to", "arsenic", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [12, 13]}}
{"token": ["Rescue", "of", "the", "C1335192#ent", "<e1>", "mutant", "phenotypes", "by", "C1709387#ent", "<e2>", "suggests", "that", "C1335192#ent", "<e1>", "acts", "as", "a", "transcriptional", "activator", "embryogenesis", "."], "h": {"id": "C1709387", "name": "C1709387#ent", "pos": [8, 9]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335192", "name": "C1335192#ent", "pos": [3, 4]}}
{"token": ["Piperonal", ",", "once", "used", "to", "kill", "C0030756#ent", "<e1>", "in", "Australian", "hospitals", "was", "acclaimed", "as", "an", "effective", "C3536707#ent", "<e2>", "(", "Corlette", ",", "1925", ")", "by", "the", "standards", "of", "the", "day", "."], "h": {"id": "C0030756", "name": "C0030756#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C3536707", "name": "C3536707#ent", "pos": [16, 17]}}
{"token": ["C1615557#ent", "<e1>", "(", "gal-10", ",", "also", "known", "as", "C1332765#ent", "<e2>", "is", "a", "member", "of", "the", "galectin", "family", "of", "beta-galactoside", "binding", "proteins", "is", "expressed", "uniquely", "in", "eosinophilic", "and", "basophilic", "leukocytes", "."], "h": {"id": "C1615557", "name": "C1615557#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332765", "name": "C1332765#ent", "pos": [8, 9]}}
{"token": ["Though", "the", "positive", "inotropic", "effect", "C4085337#ent", "<e1>", "was", "slightly", "decreased", "by", "pretreatment", "with", "C0031441#ent", "<e2>", ",", "such", "was", "almost", "completely", "antagonized", "by", "propranolol", "."], "h": {"id": "C4085337", "name": "C4085337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031441", "name": "C0031441#ent", "pos": [13, 14]}}
{"token": ["This", "indicates", "that", "C0017789#ent", "<e1>", "uptake", "is", "lower", "in", "glial", "cells", "exposed", "to", "THC", ",", "since", "C1705766#ent", "<e2>", "expression", "is", "lower", "than", "in", "older", "controls", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705766", "name": "C1705766#ent", "pos": [16, 17]}}
{"token": ["Inactivation", "of", "C1413248#ent", "<e1>", "has", "no", "effect", "D-alanine", "ester", "content", "of", "both", "LTA", "and", "C1424590#ent", "<e2>", ",", "and", "at", "present", "we", "can", "not", "propose", "any", "function", "for", "its", "gene", "product"], "h": {"id": "C1413248", "name": "C1413248#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424590", "name": "C1424590#ent", "pos": [14, 15]}}
{"token": ["KN-62", ",", "a", "specific", "inhibitor", "of", "calmodulin-dependent", "protein", "kinase", "II", "on", "the", "monolayer", "like", "PIM", ",", "whereas", "ML-7", ",", "a", "specific", "inhibitor", "of", "C0027120#ent", "<e1>", "inhibited", "lymphoid", "cell", "like", "C0040979#ent", "<e2>", "and", "CP", "."], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [29, 30]}}
{"token": ["Several", "C0022173#ent", "<e1>", "encoded", "by", "the", "lip", "gene", "family", "namely", "C1418785#ent", "<e2>", "to", "lip7", ",", "possess", "distinct", "thermal", "stability", "substrate", "specificity", ",", "among", "which", "the", "recombinant", "LIP1", "showed", "a", "distinguished", "catalytic", "characterization", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418785", "name": "C1418785#ent", "pos": [10, 11]}}
{"token": ["The", "results", "show", "that", "Akt-dependent", "signaling", ",", "induced", "by", "cytokines", "or", "insulin", ",", "C2712370#ent", "<e1>", "the", "IKK", "subunit-dependent", "control", "of", "C1307407#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1307407", "name": "C1307407#ent", "pos": [20, 21]}}
{"token": ["Retrovirus-mediated", "gene", "transfer", "has", "been", "tested", "for", "treatment", "of", "C0012634#ent", "<e1>", "that", "specifically", "affect", "the", "hematopoietic", "system", "such", "as", "C0392607#ent", "<e2>", "chronic", "granulomatous", "disease"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0392607", "name": "C0392607#ent", "pos": [19, 20]}}
{"token": ["Expression", "of", "the", "C0376622#ent", "<e1>", ",", "mrp", ",", "and", "topoisomerase", "II", "alpha", "C0242988#ent", "<e2>", "analyzed", "by", "reverse", "transcription-polymerase", "chain", "reaction"], "h": {"id": "C0376622", "name": "C0376622#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242988", "name": "C0242988#ent", "pos": [12, 13]}}
{"token": ["Pulmonary", "arterial", "hypertension", "C1418251#ent", "<e1>", ")", ",", "caused", "by", "collagen", "diseases", "C0013743#ent", "<e2>", "of", "idiopathic", "etiology", "generally", "has", "a", "poor", "prognosis"], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013743", "name": "C0013743#ent", "pos": [11, 12]}}
{"token": ["A", "treatment", "algorithm", "on", "the", "one", "used", "in", "the", "treatment", "of", "C1418251#ent", "<e1>", "patients", "is", "proposed", "for", "patients", "with", "C1418251#ent", "<e1>", "associated", "with", "corrected", "and", "uncorrected", "congenital", "systemic-to-pulmonary", "shunts", "and", "C0013743#ent", "<e1>"], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013743", "name": "C0013743#ent", "pos": [30, 31]}}
{"token": ["Addition", "of", "thrombin", "inhibitor", "C1451270#ent", "<e1>", "and", "heparin", "inhibitor", "C0282194#ent", "<e2>", "into", "the", "reacting", "thrombin-AT", "mixture", "did", "not", "interfere", "with", "the", "assay", "of", "TAT", "."], "h": {"id": "C1451270", "name": "C1451270#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282194", "name": "C0282194#ent", "pos": [9, 10]}}
{"token": ["C0002333#ent", "<e1>", "is", "extensively", "metabolized", "by", "C1142644#ent", "<e2>", "."], "h": {"id": "C0002333", "name": "C0002333#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}}
{"token": ["Potential", "pharmacokinetic", "effects", "of", "venlafaxine", "on", "C0002333#ent", "<e1>", ",", "a", "substrate", "of", "the", "cytochrome", "pigment", "450", "CYP", ")", "isoenzyme", "C1142644#ent", "<e2>", ",", "were", "investigated", "in", "16", "healthy", "volunteers"], "h": {"id": "C0002333", "name": "C0002333#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [19, 20]}}
{"token": ["Cell-associated", "C0078956#ent", "<e1>", "deacylated", "to", "form", "active", "SkPl", "which", "hydrolyzed", "S-2251", "and", "C0659021#ent", "<e2>"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0659021", "name": "C0659021#ent", "pos": [12, 13]}}
{"token": ["The", "configurational", "distribution", "of", "phosphoglycerate", "kinase", "PGK", ")", "strongly-denatured", "in", "4", "C0120447#ent", "<e1>", "is", "investigated", "using", "small-angle", "neutron", "scattering", "C3714952#ent", "<e2>", ")", "and", "Monte", "Carlo", "computer", "simulation"], "h": {"id": "C0120447", "name": "C0120447#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3714952", "name": "C3714952#ent", "pos": [19, 20]}}
{"token": ["Many", "families", "with", "C2931689#ent", "<e1>", "appear", "to", "have", "more", "benign", "C0037285#ent", "<e2>", "less", "severe", "prognosis", "compared", "to", "DM1", "."], "h": {"id": "C2931689", "name": "C2931689#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [10, 11]}}
{"token": ["A", "10-year-old", "boy", "with", "the", "C0599035#ent", "<e1>", ",", "hyperammonemia", "and", "homocitrullinuria", "(", "C0268540#ent", "<e2>", ")", "syndrome", "is", "described", "."], "h": {"id": "C0599035", "name": "C0599035#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0268540", "name": "C0268540#ent", "pos": [12, 13]}}
{"token": ["Peptide", "libraries", "incubated", "for", "a", "short", "time", "the", "presence", "of", "C1442788#ent", "<e1>", "and", "phages", "displaying", "efficiently", "phosphorylated", "C0030956#ent", "<e2>", "were", "selected", "by", "panning", "over", "anti-phosphotyrosine", "antibodies", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}}
{"token": ["Src", "and", "C1442788#ent", "<e1>", "phosphorylated", "similar", "sites", "in", "NR2A", "and", "NR2B", ",", "C0030956#ent", "<e2>", "identifying", "seven", "and", "five", "major", "tyrosine-phosphorylated", "peptides", "derived", "from", "NR2A", "and", "NR2B", ",", "respectively", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["Restrictive", "cardiac", "valvulopathies", "observed", "in", "Parkinson", "patients", "treated", "with", "C0031007#ent", "<e1>", "recently", "been", "associated", "with", "agonist", "efficacy", "of", "the", "C0013227#ent", "<e2>", "at", "5-hydroxytryptamine2B", "(", "5-HT2B", ")", "receptors", "."], "h": {"id": "C0031007", "name": "C0031007#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [19, 20]}}
{"token": ["L-NAME", "increased", "contractile", "responses", "C0031469#ent", "<e1>", "in", "mRen-2", "rats", "and", ",", "after", "C0132555#ent", "<e2>", "responses", "to", "C0031469#ent", "<e1>", "became", "comparable", "in", "both", "strains", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [4, 5]}}
{"token": ["C0039520#ent", "<e1>", "concurrent", ",", "associated", "C0029443#ent", "<e2>", "the", "lateral", "proximal", "sesamoid", "bone", "diagnosed", "in", "a", "seven-year-old", "thoroughbred", "gelding", "."], "h": {"id": "C0039520", "name": "C0039520#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [5, 6]}}
{"token": ["The", "region", "of", "C1377871#ent", "<e1>", "in", "the", "interaction", "with", "C1456386#ent", "<e2>", "was", "mapped", "to", "the", "C-terminus", "of", "C1377871#ent", "<e1>"], "h": {"id": "C1377871", "name": "C1377871#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1456386", "name": "C1456386#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "C0242975#ent", "<e1>", "baclofen", "were", "investigated", "on", "the", "secretion", "of", "GH", ",", "C1538681#ent", "<e2>", ",", "ACTH", "and", "TSH", "from", "the", "anterior", "pituitary", "in", "vitro", "a", "rapid", "superfusion", "system"], "h": {"id": "C0242975", "name": "C0242975#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1538681", "name": "C1538681#ent", "pos": [14, 15]}}
{"token": ["Three", "patients", "with", "proved", "C0149853#ent", "<e1>", "diseased", "external", "carotid", "artery", "common", "carotid", "artery", "C0339527#ent", "<e2>", "fugax", "."], "h": {"id": "C0149853", "name": "C0149853#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0339527", "name": "C0339527#ent", "pos": [13, 14]}}
{"token": ["We", "also", "show", "that", "the", "presence", "of", "BRCA1", "is", "dispensable", "for", "DNA", "damage-induced", "phosphorylation", "Rad9", ",", "C1415818#ent", "<e1>", "and", "C2984188#ent", "<e2>", ",", "and", "for", "the", "relocalization", "of", "Rad9", "and", "C1415818#ent", "<e1>", "."], "h": {"id": "C2984188", "name": "C2984188#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415818", "name": "C1415818#ent", "pos": [16, 17]}}
{"token": ["The", "C1420120#ent", "<e1>", "EAAC1", "contains", "several", "conserved", "C0815040#ent", "<e2>", "its", "transmembrane", "domain", "which", "are", "possibly", "important", "in", "catalyzing", "transport", "and/or", "binding", "of", "co/countertransported", "cations", "."], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "erbstatin", "affected", "neither", "the", "release", "of", "C0699918#ent", "<e1>", "stimulated", "by", "these", "C0243192#ent", "<e2>", "nor", "the", "release", "of", "beta-glucosaminidase", ",", "lysozyme", "or", "vitamin", "B12-binding", "protein", "induced", "by", "fMet-Leu-Phe", "."], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [14, 15]}}
{"token": ["The", "results", "showed", "C0567085#ent", "<e1>", "MXC-induced", "increases", "in", "the", "expression", "of", "C1334306#ent", "<e2>", "and", "Ang1", ",", "changes", "consistent", "with", "normal", "proliferative", "response", "to", "oestrogenic", "stimulation", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334306", "name": "C1334306#ent", "pos": [11, 12]}}
{"token": ["Four", "human", "C0017337#ent", "<e1>", "encoding", "polypeptides", "p125", "p50", ",", "p66", ",", "and", "C1422411#ent", "<e2>", "have", "been", "assigned", "as", "subunits", "of", "DNA", "polymerase", "delta"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422411", "name": "C1422411#ent", "pos": [12, 13]}}
{"token": ["C2698697#ent", "<e1>", "activated", "both", "the", "C0014442#ent", "<e2>", "with", "a", "Km", "0.057", "mM", "and", "0.2", "mM", "for", "AlaAT", "I", "and", "II", "respectively", "."], "h": {"id": "C2698697", "name": "C2698697#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}}
{"token": ["Amplification", "of", "N-myc", "C0029016#ent", "<e1>", "and", "an", "increased", "level", "of", "C0242853#ent", "<e2>", "also", "been", "demonstrated", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [10, 11]}}
{"token": ["In", "the", "Chinese", "Hamster", "Ovary", "CHO", ")", ",", "cell", "lysates", "overexpressing", "C1825853#ent", "<e1>", ",", "we", "observed", "AGPAT", "activity", "but", "not", "the", "C1825853#ent", "<e1>", "activity", "."], "h": {"id": "C1825853", "name": "C1825853#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1825853", "name": "C1825853#ent", "pos": [11, 12]}}
{"token": ["C1415193#ent", "<e1>", "expression", "is", "similar", "to", "that", "of", "C4085550#ent", "<e2>", ",", "with", "an", "overall", "decrease", "in", "the", "level", "of", "RNA", "during", "endosperm", "development", "."], "h": {"id": "C1415193", "name": "C1415193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4085550", "name": "C4085550#ent", "pos": [8, 9]}}
{"token": ["They", "are", "regulated", "by", "many", "C0387990#ent", "<e1>", "as", "Src", ",", "Jak", ",", "Syk", "and", "FAK", "C0031727#ent", "<e2>"], "h": {"id": "C0387990", "name": "C0387990#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [15, 16]}}
{"token": ["With", "the", "clinical", "success", "of", "the", "C1335238#ent", "<e1>", "pioglitazone", "(", "Actos", ")", "and", "rosiglitazone", "(", "C0875967#ent", "<e2>", ")", ",", "development", "of", "novel", "and", "potent", "insulin-sensitizing", "agents", "diverse", "clinical", "profiles", "has", "been", "accelerated", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0875967", "name": "C0875967#ent", "pos": [15, 16]}}
{"token": ["Pharmacological", "analysis", "TRESK", "to", "be", "inhibited", "by", "previously", "reported", "K+", "channel", "inhibitors", "+", ",", "propafenone", ",", "C0017628#ent", "<e1>", ",", "lidocaine", ",", "quinine", ",", "C0034414#ent", "<e2>", ",", "and", "triethanolamine", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [23, 24]}}
{"token": ["The", "subtilisin-like", "enzyme", "PC1", "(", "also", "known", "as", "C1704969#ent", "<e1>", ")", "cleaves", "the", "C1337111#ent", "<e2>", "paired", "basic", "residues", "in", "transfection", "experiments", "thus", "providing", "evidence", "for", "a", "critical", "role", "in", "precursor", "processing"], "h": {"id": "C1704969", "name": "C1704969#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [13, 14]}}
{"token": ["Analysis", "of", "epidermal", "neutral", "lipids", "and", "phospholipids", "in", "C1256263#ent", "<e1>", "oil-fed", "animals", "showed", "a", "marked", "increase", "in", "C0061078#ent", "<e2>", "and", "its", "elongase", "product", ",", "dihomogammalinolenic", "acid", "DGLA", ")", "."], "h": {"id": "C1256263", "name": "C1256263#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0061078", "name": "C0061078#ent", "pos": [17, 18]}}
{"token": ["Most", "forms", "of", "C0178782#ent", "<e1>", "neurologic", "disorders", ",", "although", "not", "life", "threatening", ",", "can", "be", "C3714552#ent", "<e2>", "."], "h": {"id": "C0178782", "name": "C0178782#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [15, 16]}}
{"token": ["The", "inhibitory", "effect", "of", "hemopexin", "was", "lost", "when", "heme", "in", "the", "medium", "was", "replaced", "by", "C0076694#ent", "<e1>", "which", "is", "bound", "less", "strongly", "by", "hemopexin", "(", "C0026691#ent", "<e2>", "approximately", "1", "microM", ")", "."], "h": {"id": "C0076694", "name": "C0076694#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [25, 26]}}
{"token": ["In", "the", "Na+-free", "(", "replaced", "with", "Li+", ")", "state", ",", "local", "application", "the", "two", "effective", "C0002062#ent", "<e1>", "produced", "a", "marked", "frequency", "increase", "of", "C3543842#ent", "<e2>", "spike", "discharges", "with", "depolarization", "of", "the", "neuronal", "membrane"], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [23, 24]}}
{"token": ["After", "11", "days", "of", "stretch", ",", "C0231528#ent", "<e1>", "increased", "60", "%", "compared", "with", "contralateral", "control", "muscles", "C1334089#ent", "<e2>", "mRNA", "levels", "increased", "three-fold", "."], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [16, 17]}}
{"token": ["The", "same", "time-course", "and", "levels", "of", "induction", "of", "C0032027#ent", "<e1>", "mRNA", "by", "dbcAMP", "and", "C0282210#ent", "<e2>", "were", "found", "in", "primary", "cultures", "indicating", "that", "both", "effectors", "act", "through", "the", "same", "mechanism", "."], "h": {"id": "C0032027", "name": "C0032027#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [14, 15]}}
{"token": ["We", "sought", "to", "determine", "the", "prevalence", "of", "previously", "unrecognized", "C0020676#ent", "<e1>", "in", "a", "series", "of", "patients", "evaluated", "for", "C0520679#ent", "<e2>", "and", "whether", "an", "association", "between", "C0020676#ent", "<e1>", "and", "C0520679#ent", "<e2>", "was", "present", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [9, 10]}}
{"token": ["Of", "290", "sequential", "patients", "referred", "to", "sleep", "clinic", "200", "(", "69", "%", ")", "patients", "judged", "at", "high", "risk", "C0520679#ent", "<e1>", "underwent", "polysomnography", "(", "PSG", ")", "and", "biochemical", "screening", "C0020676#ent", "<e2>", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [28, 29]}}
{"token": ["C0520679#ent", "<e1>", "OSA", ")", "and", "C0020676#ent", "<e2>", "relatively", "frequent", "disorders", "that", "may", "be", "causally", "linked", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [5, 6]}}
{"token": ["Severe", "C0520679#ent", "<e1>", "observed", "in", "one", "case", "with", "C0020676#ent", "<e2>", ",", "but", "there", "were", "no", "respiratory", "abnormalities", "other", "two", "cases", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [8, 9]}}
{"token": ["Both", "UspA", "and", "C3273505#ent", "<e1>", "are", "required", "in", "the", "defense", "against", "C0897757#ent", "<e2>", "and", "C3273505#ent", "<e1>", "appears", "also", "important", "in", "controlling", "intracellular", "levels", "of", "iron", "."], "h": {"id": "C3273505", "name": "C3273505#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0897757", "name": "C0897757#ent", "pos": [11, 12]}}
{"token": ["The", "C0077678#ent", "<e1>", "to", "anergy", "in", "lymphocytes", "(", "GRAIL", ")", "(", "C1427368#ent", "<e2>", ")", "is", "a", "type", "1", "transmembrane", "protein", "induces", "T", "cell", "anergy", "the", "ubiquitination", "activity", "of", "its", "cytosolic", "RING", "finger", "."], "h": {"id": "C0077678", "name": "C0077678#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1427368", "name": "C1427368#ent", "pos": [11, 12]}}
{"token": ["C0047029#ent", "<e1>", "was", "added", "to", "isolated", "rat", "liver", "mitochondria", "energized", "with", "C0220918#ent", "<e2>", ",", "and", "the", "methyl", "radical", "adduct", "was", "observed", "."], "h": {"id": "C0047029", "name": "C0047029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0220918", "name": "C0220918#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "differences", "between", "Chinese", "alcoholic", "patients", "with", "cirrhosis", "and", "C0001339#ent", "<e1>", "studying", "the", "genetic", "polymorphisms", "ADH2", ",", "C1412237#ent", "<e2>", ",", "ALDH2", ",", "and", "P4502E1", "."], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1412237", "name": "C1412237#ent", "pos": [25, 26]}}
{"token": ["To", "overcome", "these", "limitations", ",", "we", "have", "developed", "a", "humanized", "mouse", "model", "allergic", "cutaneous", "reaction", "severe", "combined", "C0221026#ent", "<e1>", "with", "skin", "and", "C1881195#ent", "<e2>", "allergic", "donors"], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1881195", "name": "C1881195#ent", "pos": [22, 23]}}
{"token": ["The", "1H", "nuclear", "magnetic", "resonance", "NMR", ")", "spectrum", "of", "C1413043#ent", "<e1>", "+", "-saturated", "porcine", "calbindin", "D9k", "(", "78", "C3539946#ent", "<e2>", "Mr", "8800", ")", "has", "been", "assigned", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [18, 19]}}
{"token": ["The", "genetic", "polymorphisms", "aldehyde", "dehydrogenase-2", "ALDH2", ")", ",", "alcohol", "dehydrogenase-1B", "ADH1B", ",", "previously", "called", "ADH2", ")", ",", "and", "C1312457#ent", "<e1>", "(", "previously", "called", "C1412237#ent", "<e2>", ")", "affect", "the", "metabolism", "of", "alcohol", "."], "h": {"id": "C1312457", "name": "C1312457#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412237", "name": "C1412237#ent", "pos": [23, 24]}}
{"token": ["The", "C1451575#ent", "<e1>", "proto-oncogene", "encodes", "Mr", "93,000", "protein-tyrosine", "kinase", "(", "C1414588#ent", "<e2>", ")", "that", "is", "strongly", "expressed", "in", "myeloid", "cells", "has", "been", "implicated", "in", "myelomonocytic", "differentiation"], "h": {"id": "C1451575", "name": "C1451575#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414588", "name": "C1414588#ent", "pos": [10, 11]}}
{"token": ["The", "5'-3'", "orientation", "of", "the", "C1451575#ent", "<e1>", "clones", "with", "respect", "to", "C1414588#ent", "<e2>", "determined", "."], "h": {"id": "C1451575", "name": "C1451575#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414588", "name": "C1414588#ent", "pos": [11, 12]}}
{"token": ["The", "C1451575#ent", "<e1>", "encodes", "a", "structurally", "unique", "protein", "(", "C1414588#ent", "<e2>", ")", "of", "the", "nonreceptor", "protein-tyrosine", "kinase", "PTK", ")", "family", "."], "h": {"id": "C1451575", "name": "C1451575#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414588", "name": "C1414588#ent", "pos": [9, 10]}}
{"token": ["C1524095#ent", "<e1>", "therefore", "functions", "to", "promote", "C4084905#ent", "<e2>", "activation", "as", "a", "novel", "MEK-independent", "Raf", "target", "to", "control", "Survivin-mediated", "osteoclast", "survival", "."], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [6, 7]}}
{"token": ["C1524095#ent", "<e1>", "mediated", "activation", "of", "Raf", "was", "required", "for", "C4084905#ent", "<e2>", "activation", "and", "osteoclast", "survival", "by", "C4084905#ent", "<e2>", "."], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [9, 10]}}
{"token": ["Both", "general", "acid", "catalysis", "general", "base", "catalysis", "evidenced", ",", "with", "borate", ",", "C0000975#ent", "<e1>", ",", "formate", ",", "and", "phosphate", "buffers", "the", "conversion", "of", "C0008188#ent", "<e2>", "to", "lactam", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [23, 24]}}
{"token": ["In", "the", "Sophia", "Children's", "Hospital", "perform", "fiberoptic", "laryngoscopy", "neonates", "under", "general", "anesthesia", "the", "use", "of", "C3540042#ent", "<e1>", "the", "diagnostics", "of", "functional", "C0031345#ent", "<e2>"], "h": {"id": "C3540042", "name": "C3540042#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031345", "name": "C0031345#ent", "pos": [21, 22]}}
{"token": ["Since", "choledochoduodenostomy", "did", "increase", "reflux", "cholangitis", "and", "C0004623#ent", "<e1>", "increase", "mucin", "C0221406#ent", "<e2>", ",", "bile", "deconjugation", "eventually", "new", "calcium", "bilirubinate", "stones", "would", "be", "formed", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", ",", "the", "efficacy", "of", "our", "C0012383#ent", "<e1>", "was", "evaluated", "with", "a", "pig", "C0162557#ent", "<e2>", "FHF", ")", "model", "."], "h": {"id": "C0012383", "name": "C0012383#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [15, 16]}}
{"token": ["The", "role", "of", "subthalamic", "nucleus", "C1705443#ent", "<e1>", ")", "deep", "brain", "stimulation", "DBS", ")", "is", "well", "established", "in", "Parkinson's", "disease", "but", "experience", "with", "C1705443#ent", "<e1>", "DBS", "in", "other", "C0026650#ent", "<e1>", "limited", "."], "h": {"id": "C1705443", "name": "C1705443#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [27, 28]}}
{"token": ["The", "results", "of", "the", "different", "methods", "show", "that", "lovastatin", "crosses", "the", "C1801950#ent", "<e1>", "to", "a", "much", "greater", "extent", "than", "does", "C0246203#ent", "<e2>", "or", "HA", "."], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0246203", "name": "C0246203#ent", "pos": [20, 21]}}
{"token": ["In", "cells", "stably", "transfected", "with", "the", "Kir6.2", "subunit", "of", "the", "of", "C1955862#ent", "<e1>", "inhibition", "of", "glycolysis", "activated", "potassium", "current", "and", "C3537460#ent", "<e2>", "activity", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3537460", "name": "C3537460#ent", "pos": [20, 21]}}
{"token": ["Blood", "samples", "for", "the", "routine", "study", "of", "five", "children", "attended", "in", "our", "department", "were", "analysed", ":", "four", "were", "C0004096#ent", "<e1>", "and", "one", "child", "had", "C0011615#ent", "<e2>"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [18, 19]}, "relation": "manifestation_of", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [24, 25]}}
{"token": ["Imbalance", "between", "oxidative", "stress", "C0003402#ent", "<e1>", "leads", "to", "free", "radical", "damage", "considered", "to", "be", "an", "aetiological", "factor", "C0151744#ent", "<e2>", "cancer", "."], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [17, 18]}}
{"token": ["C1415855#ent", "<e1>", "overexpression", "also", "partially", "suppressed", "the", "C0020402#ent", "<e2>", "sensitivity", "characteristic", "of", "DNA", "polymerase", "delta", "mutants", "and", "mutants", "defective", "in", "the", "\"", "checkpoint", "Rad\"", "pathway"], "h": {"id": "C1415855", "name": "C1415855#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [7, 8]}}
{"token": ["Amelioration", "of", "insulin", "resistance", "associated", "with", "restoration", "of", "hepatic", "insulin", "receptor", "substrate-2", "suppression", "of", "C1418918#ent", "<e1>", "in", "restoration", "of", "C0812228#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C1418918", "name": "C1418918#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [19, 20]}}
{"token": ["b", ")", "K252a", ",", "which", "blocks", "PKC", "and", "phorbol", "12-myristate", "C1705770#ent", "<e1>", "secretion", ",", "enhances", "both", "muscarinic-stimulated", "C1370600#ent", "<e2>", "activation", "and", "C1705770#ent", "<e1>", "secretion", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705770", "name": "C1705770#ent", "pos": [10, 11]}}
{"token": ["When", "gluconeogenesis", "was", "blocked", "with", "0.15", "mM", "3-mercaptopicolinate", ",", "an", "inhibitor", "of", "C0031644#ent", "<e1>", "QO2", "increased", "together", "with", "C0025965#ent", "<e2>", "as", "perfusion", "pressure", "raised", "."], "h": {"id": "C0031644", "name": "C0031644#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0025965", "name": "C0025965#ent", "pos": [18, 19]}}
{"token": ["The", "oxidase", "of", "P.", "tigrinus", "oxidizes", "C0144291#ent", "<e1>", ",", "coniferyl", "alcohol", "ABTS", ",", "syringic", "acid", "diaminobenzidine", ",", "guaiacol", ",", "C0054858#ent", "<e2>", "and", "vanillylacetone", "with", "different", "efficiencies", "."], "h": {"id": "C0144291", "name": "C0144291#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054858", "name": "C0054858#ent", "pos": [19, 20]}}
{"token": ["The", "major", "fatty", "acids", "strains", "NCS1", ",", "C2829195#ent", "<e1>", ",", "and", "NCS3", "grown", "without", "C0069678#ent", "<e2>", "dodecanoic", ",", "tetradecanoic", ",", "hexadecanoic", ",", "hexadecenoic", ",", "and", "octadecenoic", "acids"], "h": {"id": "C2829195", "name": "C2829195#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0069678", "name": "C0069678#ent", "pos": [14, 15]}}
{"token": ["This", "induction", "signifies", "the", "presence", "of", "a", "TLR2-dependent", "but", "MyD88-independent", "M.", "tuberculosis", "signalling", "pathway", "suggesting", "involvement", "of", "adaptor", "protein(s", ")", "other", "than", "C1417530#ent", "<e1>", "in", "M.", "tuberculosis-mediated", "induction", "of", "C1366565#ent", "<e2>", "."], "h": {"id": "C1417530", "name": "C1417530#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1366565", "name": "C1366565#ent", "pos": [29, 30]}}
{"token": ["Issues", "specific", "to", "the", "IUGR", "preterm", "infant", "reviewed", "as", "well", "including", "an", "increased", "incidence", "of", "C0008679#ent", "<e1>", "necrotizing", "enterocolitis", "retinopathy", "of", "prematurity", "and", "postnatal", "C0015544#ent", "<e2>"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0015544", "name": "C0015544#ent", "pos": [24, 25]}}
{"token": ["The", "absorption", ",", "fluorescence", "emission", "visible", "C1705969#ent", "<e1>", "spectral", "measurements", "as", "well", "as", "the", "C1305923#ent", "<e2>", "27-day", "cotyledon-PSI", "complexes", "indicated", "age-induced", "association", "of", "LHCII", "of", "PSII", "with", "PSI", "obtained", "from", "27-day", "cotyledons", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}}
{"token": ["We", "focused", "on", "activation", "of", "C3849574#ent", "<e1>", ",", "JNK", ",", "p38", ",", "and", "Akt", ",", "C0031727#ent", "<e2>", "that", "regulate", "multiple", "processes", "cell", "survival", "proliferation", ",", "and", "migration", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "both", "SEK1", "and", "MKK7", "are", "required", "for", "JNK", "phosphorylation", ",", "whereas", "their", "role", "in", "p38", "and", "C3849574#ent", "<e1>", "phosphorylation", "could", "overlap", "with", "that", "of", "another", "C0031727#ent", "<e2>", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [18, 19]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [27, 28]}}
{"token": ["It", "is", "important", "that", "C0025229#ent", "<e1>", "be", "considered", "in", "the", "differential", "diagnosis", "C0156147#ent", "<e2>", "the", "treatment", "is", "quite", "different", "from", "tuberculosis", "."], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [12, 13]}}
{"token": ["C0669358#ent", "<e1>", "induced", "a", "decrease", "in", "endothelial", "nitric", "oxide", "synthase", "C0669365#ent", "<e2>", ")", "mRNA", "expression", "and", "enzyme", "activity"], "h": {"id": "C0669358", "name": "C0669358#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [10, 11]}}
{"token": ["Three", "benzene-carboxylic", "acids", "C0053502#ent", "<e1>", "3,5-dihydroxybenzoic", "acid", "and", "phthalic", "acid", "and", "two", "peptides", "(", "C1648700#ent", "<e2>", ",", "and", "glycil-l-leucine", ")", "were", "employed", "to", "simulate", "the", "major", "acidic", "functional", "groups", "present", "in", "humic", "material"], "h": {"id": "C0053502", "name": "C0053502#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1648700", "name": "C1648700#ent", "pos": [14, 15]}}
{"token": ["The", "receptor", "tyrosine", "kinase", "ERBB4/HER4", "referred", "to", "here", "as", "C1704826#ent", "<e1>", ")", "undergoes", "sequential", "processing", "by", "C0529196#ent", "<e2>", "presenilin-dependent", "gamma-secretase", "to", "release", "the", "C1704826#ent", "<e1>", "ICD", "(", "4ICD", ")", "."], "h": {"id": "C1704826", "name": "C1704826#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0529196", "name": "C0529196#ent", "pos": [16, 17]}}
{"token": ["The", "cellular", "and", "subcellular", "localizations", "the", "AE2", "anion", "exchanger", "in", "rat", "kidney", "have", "remained", "elusive", "despite", "detection", "of", "moderately", "abundant", "C1420194#ent", "<e1>", "mRNA", "and", "C1305923#ent", "<e2>", "all", "kidney", "regions"], "h": {"id": "C1420194", "name": "C1420194#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [24, 25]}}
{"token": ["The", "first", "enzyme", "D-hydantoinase", "C0020208#ent", "<e1>", "to", "carbamoyl", "derivatives", "which", "were", "further", "converted", "to", "D-amino", "acids", "C0041945#ent", "<e2>", "."], "h": {"id": "C0020208", "name": "C0020208#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041945", "name": "C0041945#ent", "pos": [16, 17]}}
{"token": ["Interestingly", ",", "such", "LTP", "was", "not", "affected", "by", "a", "Ca2+/calmodulin-dependent", "protein", "kinase", "II", "or", "a", "peptide", "binding", "a", "C1423524#ent", "<e1>", "C", "kinase", "1", "but", "was", "blocked", "by", "a", "peptide", "binding", "C0067966#ent", "<e2>", "which", "specifically", "binds", "to", "GluR2", "."], "h": {"id": "C1423524", "name": "C1423524#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0067966", "name": "C0067966#ent", "pos": [30, 31]}}
{"token": ["The", "expression", "of", "cMRP", "and", "MRP", "in", "human", "C0023899#ent", "<e1>", "and", "of", "C3539701#ent", "<e2>", "and", "its", "homolog", "Mrp", "rat", "C0023899#ent", "<e1>", "was", "demonstrated", "by", "reverse", "transcription", "PCR", "cDNA", "sequencing", "and", "immunoblotting", "(", "13", ")", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539701", "name": "C3539701#ent", "pos": [12, 13]}}
{"token": ["These", "studies", "demonstrate", "the", "presence", "of", "an", "ATP-dependent", "Cu", "transporting", "system", "isolated", "plasma", "membrane", "of", "rat", "C0023899#ent", "<e1>", "distinct", "from", "C3539701#ent", "<e2>", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539701", "name": "C3539701#ent", "pos": [20, 21]}}
{"token": ["This", "implies", "active", "screening", "the", "carotid", "arteries", "patients", "with", "clinically", "manifested", "chronic", "arterial", "failure", "the", "C0030196#ent", "<e1>", "of", "with", "C0151744#ent", "<e2>"], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [19, 20]}}
{"token": ["Furosemide", ",", "C0024730#ent", "<e1>", ",", "and", "verapamil", "converted", "C0028961#ent", "<e2>", "into", "non-oliguric", "ARF", "in", "100", "%", ",", "75", "%", ",", "and", "60", "%", "of", "the", "animals", ",", "resp", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0028961", "name": "C0028961#ent", "pos": [8, 9]}}
{"token": ["Furosemide", ",", "C0024730#ent", "<e1>", "and", "dopamine", "were", "used", "in", "horses", "with", "C0028961#ent", "<e2>", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0028961", "name": "C0028961#ent", "pos": [11, 12]}}
{"token": ["Use", "of", "automated", "biochemical", "monitoring", ",", "aminoglycoside", "antibiotic", "utilization", ",", "and", "administration", "of", "potent", "diuretics", "and", "C0024730#ent", "<e1>", "in", "settings", "of", "C0028961#ent", "<e2>", "all", "contribute", "to", "its", "increased", "incidence", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0028961", "name": "C0028961#ent", "pos": [21, 22]}}
{"token": ["Guanylate", "kinase", "structurally", "related", "to", "adenylate", "kinases", "C0752065#ent", "<e1>", "with", "respect", "to", "its", "central", "beta-sheet", "C0056248#ent", "<e2>", "helices", "and", "the", "giant", "anion", "hole", "that", "binds", "nucleoside", "triphosphates"], "h": {"id": "C0752065", "name": "C0752065#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0056248", "name": "C0056248#ent", "pos": [15, 16]}}
{"token": ["An", "open", "reading", "frame", "C3715179#ent", "<e1>", ")", "encoding", "a", "C0014628#ent", "<e2>", "EHase", ")", "was", "identified", "by", "analyzing", "the", "genome", "sequence", "Sphingophyxis", "alaskensis", "."], "h": {"id": "C3715179", "name": "C3715179#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014628", "name": "C0014628#ent", "pos": [9, 10]}}
{"token": ["The", "major", "physiological", "regulator", "of", "human", "C3254086#ent", "<e1>", "expression", "in", "the", "ovary", "is", "follicle", "stimulating", "hormone", "C0016424#ent", "<e2>", ")", ",", "which", "acts", "by", "increasing", "intracellular", "cAMP", "levels", "."], "h": {"id": "C3254086", "name": "C3254086#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [16, 17]}}
{"token": ["Most", "significantly", ",", "levels", "of", "cyclins", "D1", "C1414052#ent", "<e1>", "were", "markedly", "diminished", "with", "Cdx1", "expression", ",", "but", "not", "C0173532#ent", "<e2>", "E", ",", "or", "the", "G(1", ")", "kinases", "."], "h": {"id": "C1414052", "name": "C1414052#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0173532", "name": "C0173532#ent", "pos": [18, 19]}}
{"token": ["We", "found", "that", "C0056557#ent", "<e1>", "inhibited", "basal", "and", "tumor", "necrosis", "factor-alpha", "C0812246#ent", "<e2>", ")", "stimulated", "ET-1", "secretion", "in", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0056557", "name": "C0056557#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}}
{"token": ["In", "the", "third", "experiment", ",", "COCs", "were", "placed", "in", "maturation", "medium", "vehicle", "(", "0.5", "%", "[", "v/v", "]", "DMSO", ")", "or", "200", "nM", "C0671700#ent", "<e1>", ",", "an", "inhibitor", "of", "C0010656#ent", "<e2>"], "h": {"id": "C0671700", "name": "C0671700#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [29, 30]}}
{"token": ["However", ",", "C0162429#ent", "<e1>", "decreases", "spleen", "weights", "more", "than", "C0001962#ent", "<e2>"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "an", "insertion", "mutant", "of", "mtlA", "could", "grow", "on", "glucitol", "but", "not", "on", "C0024730#ent", "<e1>", "in", "the", "presence", "or", "absence", "of", "C0039512#ent", "<e2>", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [23, 24]}}
{"token": ["The", "frequency", "of", "gap", "repair", "reduced", "2-fold", "in", "C1568501#ent", "<e1>", "mutants", "and", "C0014877#ent", "<e2>", "over", "was", "reduced", ",", "consistent", "with", "role", "for", "Rad1", "in", "cleaving", "recombination", "intermediates", "."], "h": {"id": "C1568501", "name": "C1568501#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014877", "name": "C0014877#ent", "pos": [12, 13]}}
{"token": ["Immunofluorescence", "staining", "RPTC", "with", "monoclonal", "antibodies", "to", "neutral", "endopeptidase", "C1366499#ent", "<e1>", ")", ",", "and", "C1447020#ent", "<e2>", "DPP", "II", "showed", "similar", "extensive", "labelling", "with", "DPP", "and", "C1366499#ent", "<e1>", "in", "both", "culture", "conditions"], "h": {"id": "C1447020", "name": "C1447020#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1366499", "name": "C1366499#ent", "pos": [9, 10]}}
{"token": ["C3854222#ent", "<e1>", "HIV-1", ",", "was", "also", "susceptible", "to", "C0056337#ent", "<e2>", "+", "UVA", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0056337", "name": "C0056337#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "demonstrate", "in", "vitro", "formation", "of", "a", "nearly", "stoichiometric", "quaternary", "complex", "C1414323#ent", "<e1>", "and", "the", "minimal", "segments", "of", "C1414335#ent", "<e2>", ",", "eIF3c", ",", "and", "eIF5", "."], "h": {"id": "C1414323", "name": "C1414323#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414335", "name": "C1414335#ent", "pos": [19, 20]}}
{"token": ["We", "investigated", "the", "role", "of", "PPARgamma", "during", "the", "inflammatory", "response", "C0036690#ent", "<e1>", "by", "the", "use", "of", "the", "C1335238#ent", "<e2>", "15-deoxy-Delta(12,14)-PGJ(2", ")", "(", "15d-PGJ(2", ")", ")", "and", "ciglitazone", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [17, 18]}}
{"token": ["Two", "cases", "of", "C0238096#ent", "<e1>", "bronchial", "constriction", "inhalation", "of", "C0015840#ent", "<e2>", "and", "ipratropium", "bromide", "presented", "."], "h": {"id": "C0238096", "name": "C0238096#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015840", "name": "C0015840#ent", "pos": [9, 10]}}
{"token": ["C0022625#ent", "<e1>", "and", "troleandomycin", ",", "selective", "inhibitors", "C1142644#ent", "<e2>", ",", "and", "polyclonal", "antibodies", "against", "CYP3A4/5", "markedly", "reduced", "the", "CL(int", ")", "of", "gallopamil", "enantiomers", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [7, 8]}}
{"token": ["The", "main", "objective", "of", "this", "study", "was", "to", "assess", "the", "effects", "of", "oral", "C0022625#ent", "<e1>", ",", "a", "potent", "inhibitor", "of", "the", "cytochrome", "P450", "3A4", "C1142644#ent", "<e2>", ")", "isoenzyme", ",", "on", "the", "pharmacokinetics", "of", "maribavir", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [13, 14]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [24, 25]}}
{"token": ["In", "this", "study", "lipid", "composition", "lipoprotein", "fractions", "LDL", "VLDL", "and", "HDL", "was", "determined", "in", "30", "men", "with", "C0020476#ent", "<e1>", "IIa", "and", "IIb", "during", "C0024027#ent", "<e2>", "treatment", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0024027", "name": "C0024027#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "the", "HCM", "is", "a", "necessary", "and", "sufficient", "contribution", "of", "C1418285#ent", "<e1>", "for", "oncogenesis", "induced", "by", "C0289575#ent", "<e2>", "and", "accounts", "for", "its", "homeodomain-independent", "transforming", "properties", "."], "h": {"id": "C1418285", "name": "C1418285#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0289575", "name": "C0289575#ent", "pos": [17, 18]}}
{"token": ["In", "exocrine", "pancreatic", "cancer", "caffeine", ",", "other", "coffee", "compounds", "or", "other", "factors", "with", "which", "coffee", "drinking", "associated", "could", "modulate", "C0079973#ent", "<e1>", "activation", "by", "interfering", "with", "C1333237#ent", "<e2>", "cell-cycle", "checkpoints", "and", "apoptosis", "."], "h": {"id": "C0079973", "name": "C0079973#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [25, 26]}}
{"token": ["Perhaps", "the", "first", "case", "of", "a", "patient", "who", "developed", "a", "transient", "C0020550#ent", "<e1>", "discontinuation", "of", "a", "lengthy", "intake", "of", "a", "C0033705#ent", "<e2>", "is", "reported", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033705", "name": "C0033705#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "simple", "and", "successful", "protocol", "for", "the", "preparation", "and", "use", "of", "intravenous", "methimazole", "MMI", ")", "for", "treatment", "of", "C0020550#ent", "<e1>", "in", "patients", "intolerant", "of", "orally", "and", "rectally", "administered", "C0033705#ent", "<e2>", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0033705", "name": "C0033705#ent", "pos": [30, 31]}}
{"token": ["Although", "the", "effects", "of", "C1705750#ent", "<e1>", "on", "the", "progression", "of", "atherosclerosis", "are", "still", "unclear", ",", "there", "is", "a", "possibility", "that", "C1705750#ent", "<e1>", "will", "become", "a", "promising", "therapy", "for", "C0151744#ent", "<e1>"], "h": {"id": "C1705750", "name": "C1705750#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [28, 29]}}
{"token": ["We", "report", "a", "female", "with", "C0009324#ent", "<e1>", "who", "developed", "a", "vesicular", "and", "C0085641#ent", "<e2>", "associated", "with", "exacerbation", "of", "her", "colonic", "disease"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085641", "name": "C0085641#ent", "pos": [12, 13]}}
{"token": ["To", "estimate", "the", "cost", "effectiveness", "of", "cilostazol", "(", "Pletal", ")", "compared", "to", "C0027329#ent", "<e1>", "and", "pentoxifylline", "(", "C0699487#ent", "<e2>", ")", "in", "the", "treatment", "of", "intermittent", "claudication", "in", "the", "UK", "."], "h": {"id": "C0027329", "name": "C0027329#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0699487", "name": "C0699487#ent", "pos": [17, 18]}}
{"token": ["Both", "enzymes", "are", "dimeric", "with", "a", "molecular", "mass", "88", "kDa", "for", "the", "C0211705#ent", "<e1>", "and", "112", "kDa", "for", "the", "C0030016#ent", "<e2>", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [19, 20]}}
{"token": ["Results", "obtained", "with", "synthetic", "ARG5", "and", "ARG6", "genes", "suggested", "that", "both", "the", "C0211705#ent", "<e1>", "and", "the", "C0030016#ent", "<e2>", "could", "be", "needed", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [16, 17]}}
{"token": ["A", "region", "of", "NF1", "gene", "product", "has", "been", "demonstrated", "to", "share", "structural", "and", "functional", "similarities", "with", "the", "mammalian", "GTPase", "activating", "protein", "C2984553#ent", "<e1>", ")", "and", "the", "C0949988#ent", "<e2>"], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0949988", "name": "C0949988#ent", "pos": [26, 27]}}
{"token": ["Recent", "evidences", "have", "suggested", "a", "cross-talk", "between", "C1706481#ent", "<e1>", "functions", "and", "the", "C0752312#ent", "<e2>", "MAPK", ")", "cascade", "."], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [12, 13]}}
{"token": ["Norfloxacin", "and", "ciprofloxacin", "were", "most", "affected", "by", "the", "C0815040#ent", "<e1>", "pH.", "Ofloxacin", "and", "C0100710#ent", "<e2>", "were", "affected", "to", "a", "lesser", "extent", "by", "an", "C0815040#ent", "<e1>", "pH", "than", "norfloxacin", "and", "ciprofloxacin", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0100710", "name": "C0100710#ent", "pos": [13, 14]}}
{"token": ["The", "high", "mortality", "and", "morbidity", "rates", "infants", "who", "experience", "C0036572#ent", "<e1>", "make", "it", "imperative", "that", "the", "C0159020#ent", "<e2>", "recognized", ",", "its", "etiology", "diagnosed", ",", "and", "treatment", "begun", "promptly", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0159020", "name": "C0159020#ent", "pos": [16, 17]}}
{"token": ["Of", "children", "with", "C0036572#ent", "<e1>", ",", "10", "%", "had", "had", "a", "C0159020#ent", "<e2>", "13", "%", "had", "had", "a", "febrile", "seizure"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0159020", "name": "C0159020#ent", "pos": [11, 12]}}
{"token": ["The", "data", "indicate", "that", "C3538856#ent", "<e1>", "is", "essential", "for", "triggering", "C0008145#ent", "<e2>", "expression", "in", "T.", "atroviride", "and", "that", "its", "functional", "impairment", "biocontrol", "by", "T.", "atroviride", "by", "a", "significant", "extent", "."], "h": {"id": "C3538856", "name": "C3538856#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008145", "name": "C0008145#ent", "pos": [10, 11]}}
{"token": ["Metformin", "has", "no", "effect", "the", "rate", "of", "lactate", "turnover", "gluconeogenesis", "from", "C0376261#ent", "<e1>", "in", "either", "the", "basal", "or", "C4082284#ent", "<e2>"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [18, 19]}}
{"token": ["The", "C1413231#ent", "<e1>", "was", "to", "investigate", "early", "and", "long-term", "results", "following", "C1705543#ent", "<e2>", "repair", "during", "a", "20-year", "period", "."], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [11, 12]}}
{"token": ["The", "C1413231#ent", "<e1>", "was", "to", "study", "the", "epidemiology", "of", "abdominal", "aortic", "aneurysm", "C1705543#ent", "<e2>", ")", "repair", "in", "Sweden", "."], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [12, 13]}}
{"token": ["When", "animals", "were", "pre-treated", "with", "different", "doses", "of", "the", "C0178601#ent", "<e1>", "SCH", "23390", ",", "or", "the", "D-2", "dopamine", "receptor", "antagonist", "sulpiride", ",", "the", "C1412446#ent", "<e2>", "response", "was", "decreased", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412446", "name": "C1412446#ent", "pos": [23, 24]}}
{"token": ["When", "animals", "were", "pre-treated", "with", "different", "doses", "of", "the", "D-1", "dopamine", "receptor", "antagonist", "SCH", "23390", ",", "or", "the", "C0178601#ent", "<e1>", "sulpiride", ",", "the", "C1412446#ent", "<e2>", "response", "was", "decreased", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412446", "name": "C1412446#ent", "pos": [23, 24]}}
{"token": ["T", "cell", "death", "reduced", "after", "treatment", "of", "C0919442#ent", "<e1>", "in", "vitro", "with", "antibody", "to", "FAS", "ligand", "(", "C1539478#ent", "<e2>", ")", "."], "h": {"id": "C0919442", "name": "C0919442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [17, 18]}}
{"token": ["ADP-glucose", "pyrophosphorylase", "a", "key", "regulatory", "enzyme", "C0054259#ent", "<e1>", "biosynthesis", ",", "is", "composed", "of", "a", "pair", "of", "catalytic", "small", "subunits", "C0037052#ent", "<e2>", ")", "and", "a", "pair", "of", "catalytically", "disabled", "subunits", "(", "LSs", ")", "."], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037052", "name": "C0037052#ent", "pos": [19, 20]}}
{"token": ["We", "further", "show", "that", "SSS", "II", "is", "the", "major", "enzyme", "involved", "in", "the", "synthesis", "of", "crystalline", "structures", "in", "C0054259#ent", "<e1>", "and", "demonstrate", "that", "C0037052#ent", "<e2>", "builds", "a", "new", "type", "of", "amylopectin", "structure"], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0037052", "name": "C0037052#ent", "pos": [23, 24]}}
{"token": ["Nucleotide", "sequence", "analysis", "the", "presence", "of", "a", "potential", "C0022895#ent", "<e1>", "with", "the", "gene", "order", "pyrG", ",", "C3810583#ent", "<e2>", ",", "eno", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3810583", "name": "C3810583#ent", "pos": [16, 17]}}
{"token": ["These", "mutations", "confer", "temperature", "sensitive", "X-ray", "sensitivity", "that", "is", "C1709801#ent", "<e1>", "and", "rad55", "strains", "display", "a", "C1883559#ent", "<e2>", "response", "at", "permissive", "temperatures", "a", "radiosensitive", "X-ray", "survival", "at", "restrictive", "temperatures"], "h": {"id": "C1709801", "name": "C1709801#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [16, 17]}}
{"token": ["The", "inhibition", "of", "superoxide", "production", "probably", "important", "in", "the", "effect", "of", "C0031990#ent", "<e1>", "and", "other", "non-steroidal", "anti-inflammatory", "drugs", "C0038013#ent", "<e2>"], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [18, 19]}}
{"token": ["Induction", "of", "phoPR", "upon", "phosphate", "starvation", "activity", "of", "both", "C1704840#ent", "<e1>", "and", "PhoR", ",", "suggesting", "autoregulation", "of", "the", "C0022895#ent", "<e2>", ",", "a", "suggestion", "that", "is", "supported", "here", "by", "PhoP", "footprinting", "the", "phoPR", "promoter", "."], "h": {"id": "C1704840", "name": "C1704840#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [18, 19]}}
{"token": ["C1704840#ent", "<e1>", "and", "phoQ", "form", "an", "C0022895#ent", "<e2>", "with", "two", "promoters", "in", "both", "E.", "coli", "Salmonella", "serovar", "Typhimurium"], "h": {"id": "C1704840", "name": "C1704840#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [6, 7]}}
{"token": ["To", "evaluate", "the", "effect", "of", "noradrenaline", "infusion", "in", "a", "case", "of", "hyperdynamic", "septic", "shock", "refractory", "to", "volume", "loading", "dopamine", "and", "C0700450#ent", "<e1>", ",", "on", "hemodynamic", "parameters", ",", "oxygen", "transport", "C0376261#ent", "<e2>", "and", "pyruvate", "levels"], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0376261", "name": "C0376261#ent", "pos": [29, 30]}}
{"token": ["Based", "on", "the", "inhibitory", "effect", "of", "inhibitors", "p-CMB", ",", "EDTA", ",", "malathion", ",", "C1161347#ent", "<e1>", "eserine", "sulphate", "the", "various", "esterases", "have", "been", "classified", "into", "C1418754#ent", "<e2>", ",", "carboxylesterase", ",", "acetylesterase", "and", "cholinesterase", "."], "h": {"id": "C1161347", "name": "C1161347#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418754", "name": "C1418754#ent", "pos": [24, 25]}}
{"token": ["Children", "that", "developed", "C0022660#ent", "<e1>", "dialysis", "due", "to", "C0678236#ent", "<e2>", "a", "higher", "mortality", "rate", "those", "that", "had", "primary", "renal", "disease", "57", "%", "versus", "12.5", "%", ",", "P", "<", "0.05", ")", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0678236", "name": "C0678236#ent", "pos": [8, 9]}}
{"token": ["C0242192#ent", "<e1>", "can", "also", "be", "used", "to", "treat", "patients", "with", "C1366489#ent", "<e2>", "relapse", "."], "h": {"id": "C0242192", "name": "C0242192#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366489", "name": "C1366489#ent", "pos": [10, 11]}}
{"token": ["The", "main", "signs", "were", "mask", "faces", "hyporeflexia", ",", "hyperreflexia", ",", "peripheral", "neuropathy", "static", "tremors", "radiculopathy", ",", "C0030552#ent", "<e1>", "mental", "changes", "fasciculations", "and", "C0234376#ent", "<e2>", ",", "wasting", ",", "hypotonia", ",", "abnormal", "deep", "reflexes", "and", "sensory", "hyposthesia", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0234376", "name": "C0234376#ent", "pos": [22, 23]}}
{"token": ["We", "describe", "a", "patient", "with", "C0030552#ent", "<e1>", "developed", "progressive", "dementia", "and", "a", "cerebellar", "syndrome", "wide-based", "gait", "slurred", "speech", "and", "C0234376#ent", "<e2>"], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0234376", "name": "C0234376#ent", "pos": [19, 20]}}
{"token": ["Clinical", "examination", "C0030552#ent", "<e1>", "hypotonia", ",", "muscle", "hypotrophy", "bilateral", "ptosis", "partial", "bilateral", "external", "ophthalmoplegia", "nystagmus", ",", "C0234376#ent", "<e2>", "hypoactive", "tendon", "reflexes"], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0234376", "name": "C0234376#ent", "pos": [16, 17]}}
{"token": ["This", "new", "cell", "line", "expressed", "glycoporin", "A", "C2323772#ent", "<e1>", "gamma", "globin", "chain", "mRNA", "but", "also", "C0059407#ent", "<e2>"], "h": {"id": "C2323772", "name": "C2323772#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0059407", "name": "C0059407#ent", "pos": [15, 16]}}
{"token": ["Calcium", "channel", "antagonists", "CCAs", ")", "may", "either", "be", "divided", "into", "the", "C0012315#ent", "<e1>", "(", "e.g.", "amlodipine", ",", "felodipine", ",", "C0071304#ent", "<e2>", ",", "lacidipine", ",", "nilvadipine", ",", "nifedipine", ",", "nicardipine", "etc", ".", ")", ","], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [11, 12]}, "relation": "structural_class_of", "t": {"id": "C0071304", "name": "C0071304#ent", "pos": [19, 20]}}
{"token": ["In", "rings", "of", "femoral", "arteries", "C0007299#ent", "<e1>", "increased", "the", "endothelium-dependent", "relaxations", "induced", "by", "the", "C0001640#ent", "<e2>", ";", "this", "was", "not", "affected", "by", "indomethacin", "but", "prevented", "by", "propranolol", "."], "h": {"id": "C0007299", "name": "C0007299#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [14, 15]}}
{"token": ["To", "study", "the", "effects", "of", "C0059752#ent", "<e1>", "(", "Vin", ")", "on", "the", "sodium", "current", "C1416431#ent", "<e2>", ")", "in", "cardiomyocytes", "."], "h": {"id": "C0059752", "name": "C0059752#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416431", "name": "C1416431#ent", "pos": [14, 15]}}
{"token": ["When", "C0245514#ent", "<e1>", "was", "coadministered", "with", "rhGH", ",", "suppressibility", "of", "C1415533#ent", "<e2>", "during", "the", "glucose", "clamp", "comparable", "to", "that", "of", "controls", "."], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415533", "name": "C1415533#ent", "pos": [10, 11]}}
{"token": ["The", "biologically", "determined", "albumin", "binding", "always", "less", "than", "the", "binding", "determined", "by", "equilibrium", "dialysis", "indicating", "that", "the", "fraction", "of", "C0936073#ent", "<e1>", "bound", "to", "C1412332#ent", "<e2>", "could", "not", "necessarily", "be", "considered", "biologically", "inactive", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [23, 24]}}
{"token": ["Receptor", "expression", "determined", "in", "renal", "biopsy", "(", "including", "all", "tissue", "components", "and", "isolated", "glomeruli", "from", "patients", "with", "C0156221#ent", "<e1>", "(", "GN", ")", "or", "C1442864#ent", "<e2>", "non-insulin-dependent", "diabetes", "mellitus", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [23, 24]}}
{"token": ["A", "4,647-bp", "DNA", "sequence", "contained", "the", "open", "reading", "frame", "C0013570#ent", "<e1>", ")", "of", "the", "C1412471#ent", "<e2>", "4,104", "bp", ")", "and", "an", "C0013570#ent", "<e1>", "of", "384", "bp", "representing", "part", "of", "the", "rpoC", "gene", "was", "obtained", "."], "h": {"id": "C0013570", "name": "C0013570#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412471", "name": "C1412471#ent", "pos": [14, 15]}}
{"token": ["To", "prepare", "monoclonal", "antibody", "to", "C1414313#ent", "<e1>", "EGFR", ")", "intracellular", "domain", ",", "its", "C0079429#ent", "<e2>", "was", "amplified", "from", "total", "RNA", "of", "A431", "cell", "by", "RT-PCR", "."], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["Sex", "steroid", "hormone", "receptors", "expressed", "in", "the", "colon", "and", "interact", "with", "C1414313#ent", "<e1>", "EGFR", ")", ",", "a", "C0079429#ent", "<e2>", "widely", "expressed", "in", "colonic", "tissue"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}}
{"token": ["We", "therefore", "attempted", "to", "induce", "B", "cells", "group", "A", "group", "B", "CVI", "patients", "to", "secrete", "C1706005#ent", "<e1>", "and", "IgG", "after", "direct", "activation", "of", "C0033634#ent", "<e2>", "with", "IL-2", "or", "IL-4", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [23, 24]}}
{"token": ["To", "report", "a", "case", "of", "C0013421#ent", "<e1>", "as", "an", "adverse", "effect", "C0060926#ent", "<e2>", "."], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [11, 12]}}
{"token": ["After", "extensive", "safety", "studies", "mice", ",", "rats", ",", "hemophilic", "dogs", "and", "C1334982#ent", "<e1>", "a", "Phase", "I", "study", "an", "AAV-mediated", ",", "liver-directed", "approach", "to", "treating", "C1366464#ent", "<e2>", "begun", "."], "h": {"id": "C1334982", "name": "C1334982#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366464", "name": "C1366464#ent", "pos": [24, 25]}}
{"token": ["Campylobacteriosis", "is", "a", "collective", "description", "for", "C0005943#ent", "<e1>", "by", "members", "of", "the", "C0017339#ent", "<e2>", "Campylobacter", "."], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017339", "name": "C0017339#ent", "pos": [12, 13]}}
{"token": ["The", "C1707136#ent", "<e1>", "promoter", "produced", "the", "least", "amount", "of", "C0432255#ent", "<e2>", ",", "GAL1", "and", "GPD", "promoters", "were", "moderate", ",", "and", "the", "ADH2-GPD", "hybrid", "promoter", "was", "the", "best", "among", "all", "tested", "."], "h": {"id": "C1707136", "name": "C1707136#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0432255", "name": "C0432255#ent", "pos": [9, 10]}}
{"token": ["The", "results", "indicate", "that", "failure", "to", "follow", "dosage", "instructions", "a", "factor", "of", "major", "importance", "among", "C0234533#ent", "<e1>", "patients", "whose", "response", "to", "treatment", "is", "inadequate", "or", "C3540540#ent", "<e2>", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540540", "name": "C3540540#ent", "pos": [25, 26]}}
{"token": ["The", "uptake", "of", "glycyl-L-proline", "and", "C0061746#ent", "<e1>", "was", "strongly", "inhibited", "by", "L-carnosine", ",", "C0281255#ent", "<e2>", ",", "and", "L-prolylglycine", "."], "h": {"id": "C0061746", "name": "C0061746#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0281255", "name": "C0281255#ent", "pos": [13, 14]}}
{"token": ["We", "performed", "a", "comparative", "analysis", "cytochrome", "P450", "C1824837#ent", "<e1>", "MFO", "associated", "enzymes", "and", "cytosolic", "C1424792#ent", "<e2>", "hepatic", "microsomes", "cytosolic", "fractions", "from", "five", "animal", "species", "three", "vertebrate", "classes", "in", "tropical", "conditions", "(", "Brazil", ")", "."], "h": {"id": "C1824837", "name": "C1824837#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1424792", "name": "C1424792#ent", "pos": [14, 15]}}
{"token": ["Results", "indicate", "that", "C3539823#ent", "<e1>", "represses", "expression", "of", "p14(ARF)", "tumor", "suppressor", "that", "a", "C3539637#ent", "<e2>", "inhibitor", "is", "able", "to", "reverse", "the", "C3539823#ent", "<e1>", "repressive", "function", "in", "a", "dosage-dependent", "manner", "."], "h": {"id": "C3539637", "name": "C3539637#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539823", "name": "C3539823#ent", "pos": [3, 4]}}
{"token": ["We", "report", "three", "new", "mutations", "in", "PTEN", ",", "the", "C0017337#ent", "<e1>", "responsible", "for", "Cowden", "disease", "five", "patients", "with", "C0265326#ent", "<e2>", "three", "unrelated", "families", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0265326", "name": "C0265326#ent", "pos": [18, 19]}}
{"token": ["Genetic", "loci", "C0017337#ent", "<e1>", "have", "been", "identified", "for", "Carney", "complex", "Peutz-Jeghers", "and", "C0265326#ent", "<e2>", "but", "not", "for", "other", "lentiginoses", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0265326", "name": "C0265326#ent", "pos": [12, 13]}}
{"token": ["Counteraction", "of", "TGF-beta", "regulation", "of", "C1565313#ent", "<e1>", "by", "HGF", "may", "in", "turn", "affect", "the", "association", "of", "C1420433#ent", "<e2>", "with", "Cdk2-cyclin", "E", "complexes", "."], "h": {"id": "C1565313", "name": "C1565313#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420433", "name": "C1420433#ent", "pos": [16, 17]}}
{"token": ["Both", "statins", "suppressed", "expression", "of", "Rb", ",", "phosphorylated", "Rb", ",", "cyclin", "D1", "cyclin", "D3", "CDK4", ",", "and", "C1565313#ent", "<e1>", ",", "but", "induced", "p21", "and", "C1420433#ent", "<e2>", "expression", "in", "prostate", "cancer", "cells", "."], "h": {"id": "C1565313", "name": "C1565313#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420433", "name": "C1420433#ent", "pos": [24, 25]}}
{"token": ["These", "effects", "were", "associated", "with", "decreased", "accumulation", "of", "cells", "in", "M", "phase", "stabilization", "of", "the", "cyclin-dependent", "kinase", "inhibitors", "C1420626#ent", "<e1>", "and", "p27", ",", "and", "inhibition", "of", "cdk2", "and", "C3811768#ent", "<e2>", "activities", "."], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3811768", "name": "C3811768#ent", "pos": [28, 29]}}
{"token": ["The", "C0057472#ent", "<e1>", "domain", "interacts", "with", "the", "C1334693#ent", "<e2>", "R7BP", "."], "h": {"id": "C0057472", "name": "C0057472#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334693", "name": "C1334693#ent", "pos": [7, 8]}}
{"token": ["It", "was", "inhibited", "by", "azide", ",", "C0056650#ent", "<e1>", ",", "and", "catalase", ",", "but", "not", "by", "C0669516#ent", "<e2>"], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [15, 16]}}
{"token": ["Toxin", "inactivation", "by", "stimulated", "neutrophils", "was", "blocked", "by", "azide", ",", "C0056650#ent", "<e1>", ",", "or", "catalase", ",", "but", "not", "by", "C0669516#ent", "<e2>"], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "suggest", "also", "that", "additional", "natural", "mutations", "especially", "K183", "M", ",", "N", ",", "or", "Q", ")", "in", "position", "183", "of", "C1336679#ent", "<e1>", "are", "expected", "to", "be", "found", "in", "C0020550#ent", "<e2>"], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [21, 22]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [29, 30]}}
{"token": ["These", "antibodies", "mimic", "the", "action", "of", "TSH", ",", "resulting", "in", "C1336679#ent", "<e1>", "stimulation", "and", "C0020550#ent", "<e2>", ",", "and", "have", "been", "associated", "with", "extrathyroidal", "manifestations", "."], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [10, 11]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [14, 15]}}
{"token": ["Hypoalbuminemia", "predicts", "mortality", "in", "hemodialysis", "patients", "with", "end-stage", "renal", "disease", "C0035078#ent", "<e1>", ")", "and", "is", "assumed", "to", "result", "from", "C0162429#ent", "<e2>", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [19, 20]}}
{"token": ["Recent", "evidence", "demonstrated", "that", "chronic", "inflammation", "a", "non-traditional", "risk", "factor", "which", "is", "commonly", "observed", "in", "C0035078#ent", "<e1>", "patients", ",", "may", "cause", "C0162429#ent", "<e2>", "and", "progressive", "atherosclerotic", "CVD", "by", "several", "pathogenetic", "mechanisms", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [21, 22]}}
{"token": ["This", "study", "was", "conducted", "to", "evaluate", "C0035078#ent", "<e1>", "an", "independent", "risk", "factor", "C0162429#ent", "<e2>", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [12, 13]}}
{"token": ["Voltage-", "and", "current-clamp", "studies", "have", "been", "performed", "on", "a", "renal", "and", "intestinal", "protein", "C2986630#ent", "<e1>", ")", "which", "induces", "transport", "for", "neutral", "and", "C0301714#ent", "<e2>", "expressed", "in", "Xenopus", "oocytes"], "h": {"id": "C2986630", "name": "C2986630#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0301714", "name": "C0301714#ent", "pos": [22, 23]}}
{"token": ["C0013230#ent", "<e1>", "malaria", "are", "greatly", "needed", ",", "and", "C1667078#ent", "<e2>", "provide", "useful", "new", "drug", "targets"], "h": {"id": "C0013230", "name": "C0013230#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1667078", "name": "C1667078#ent", "pos": [8, 9]}}
{"token": ["Infertility", "in", "those", "with", "C2316810#ent", "<e1>", "is", "a", "culmination", "of", "many", "factors", ",", "including", "C0242350#ent", "<e2>", "and", "loss", "of", "libido", "anovulation", ",", "and", "an", "altered", "hormonal", "milieu", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242350", "name": "C0242350#ent", "pos": [14, 15]}}
{"token": ["There", "are", "different", "variants", "of", "combined", "erythro-", "and", "immunopoiesis", "disorders", "in", "the", "semiallogeneic", "system", "DBA/2", "--", ">", "B6D2F1", ":", "C0221026#ent", "<e1>", "anemia", "and", "immunodeficiency", "plus", "hemolytic", "anemia", "C0744421#ent", "<e2>"], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0744421", "name": "C0744421#ent", "pos": [27, 28]}}
{"token": ["Forty-five", "had", "native", "valve", "endocarditis", "14", "had", "C0340359#ent", "<e1>", "and", "six", "had", "C0014118#ent", "<e2>", "associated", "with", "congenital", "heart", "defects"], "h": {"id": "C0340359", "name": "C0340359#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [12, 13]}}
{"token": ["At", "a", "concentration", "of", "10(-5", ")", "M", ",", "the", "strongest", "effects", "were", "noted", "with", "L-isoproterenol", ",", "L-norepinephrine", ",", "C0205758#ent", "<e1>", "and", "D", ",", "C0039086#ent", "<e2>", "."], "h": {"id": "C0205758", "name": "C0205758#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0039086", "name": "C0039086#ent", "pos": [23, 24]}}
{"token": ["C1421536#ent", "<e1>", "is", "a", "polymorphic", "locus", "is", "closely", "linked", "to", "the", "C0012634#ent", "<e2>"], "h": {"id": "C1421536", "name": "C1421536#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["C3496337#ent", "<e1>", "two", "main", "forms", "of", "glomerular", "diseases", "minimal", "change", "C0017661#ent", "<e2>", "and", "focal", "segmental", "glomerulosclerosis"], "h": {"id": "C3496337", "name": "C3496337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [10, 11]}}
{"token": ["The", "high", "C3496337#ent", "<e1>", "promoter", "profile", "G", "haplotype", "more", "frequent", "in", "patients", "with", "C0017661#ent", "<e2>", "P-value=0.005", ")", "and", "was", "associated", "with", "better", "clinical", "outcome", "terms", "of", "proteinuria", "and", "creatinine", "levels", "."], "h": {"id": "C3496337", "name": "C3496337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [13, 14]}}
{"token": ["Activation", "of", "the", "ALK", "catalytic", "domain", "results", "from", "homodimerization", "of", "the", "hybrid", "protein", "C3639982#ent", "<e1>", ",", "through", "the", "C1420874#ent", "<e2>", "protein-protein", "interaction", "domain"], "h": {"id": "C3639982", "name": "C3639982#ent", "pos": [13, 14]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1420874", "name": "C1420874#ent", "pos": [18, 19]}}
{"token": ["The", "C1318700#ent", "<e1>", "inhibitors", "are", "safe", "and", "effective", "in", "most", "patients", "with", "C0007222#ent", "<e2>", ",", "including", "those", "taking", "multiple", "antihypertensive", "drugs"], "h": {"id": "C1318700", "name": "C1318700#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [12, 13]}}
{"token": ["The", "criteria", "of", "the", "International", "Headache", "Society", "(", "IHS", ")", "define", "four", "different", "primary", "headache", "syndromes", "daily", "chronic", "headaches", "C0149931#ent", "<e1>", "episodic", "and", "chronic", "tension", "type", "headache", "C2349425#ent", "<e2>", "new", "daily", "persisting", "headache", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [19, 20]}, "relation": "nichd_parent_of", "t": {"id": "C2349425", "name": "C2349425#ent", "pos": [27, 28]}}
{"token": ["If", "the", "duration", "is", ">", "or", "=", "4", "h", ",", "a", "CDH", "is", "likely", "and", "the", "differential", "diagnosis", "C0149931#ent", "<e1>", "chronic", "tension-type", "headache", "new", "daily", "persistent", "headache", "and", "C2349425#ent", "<e2>"], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C2349425", "name": "C2349425#ent", "pos": [28, 29]}}
{"token": ["Four", "specific", "subtypes", "of", "CDH", "are", "covered", ":", "chronic", "tension-type", "headache", "C0149931#ent", "<e1>", "new", "daily", "persistent", "headache", ",", "and", "C2349425#ent", "<e2>"], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C2349425", "name": "C2349425#ent", "pos": [19, 20]}}
{"token": ["Purified", "fractions", "of", "C1822723#ent", "<e1>", "antibodies", "induced", "the", "expression", "of", "the", "C2985420#ent", "<e2>", "CD86", "on", "LSECs", "."], "h": {"id": "C1822723", "name": "C1822723#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2985420", "name": "C2985420#ent", "pos": [11, 12]}}
{"token": ["Cells", "from", "C0009207#ent", "<e1>", "patients", "with", "mutations", "in", "the", "C1333359#ent", "<e2>", "approximately", "2-fold", "reduced", "global", "repair", "thymine", "glycol"], "h": {"id": "C0009207", "name": "C0009207#ent", "pos": [2, 3]}, "relation": "disease_has_associated_gene", "t": {"id": "C1333359", "name": "C1333359#ent", "pos": [9, 10]}}
{"token": ["It", "is", "suggested", "that", "failure", "of", "fatty-acid", "(", "n-butyrate", ")", "oxidation", "in", "C0009324#ent", "<e1>", "is", "an", "expression", "of", "an", "C0011156#ent", "<e2>", "the", "colonic", "mucosa"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011156", "name": "C0011156#ent", "pos": [19, 20]}}
{"token": ["C0037533#ent", "<e1>", "SNP", ")", ",", "an", "activator", "of", "soluble", "guanylate", "cyclase", "and", "C1417809#ent", "<e2>", "both", "increase", "cGMP", "levels", "and", "short", "circuit", "in", "Calu-3", "cells", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417809", "name": "C1417809#ent", "pos": [12, 13]}}
{"token": ["South-east", "Asian", "refugees", "with", "HbAE", "or", "C1415484#ent", "<e1>", "had", "high", "C3536844#ent", "<e2>", "IFA", "titres", ",", "indicative", "of", "exposure", "to", "malaria", "more", "frequently", "than", "did", "refugees", "with", "HbAA", "."], "h": {"id": "C1415484", "name": "C1415484#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536844", "name": "C3536844#ent", "pos": [10, 11]}}
{"token": ["C0014175#ent", "<e1>", "however", ",", "contains", "very", "high", "levels", "of", "C1366496#ent", "<e2>", "enzyme", ",", "which", "leads", "to", "production", "of", "significant", "quantities", "of", "estrogen", "."], "h": {"id": "C0014175", "name": "C0014175#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1366496", "name": "C1366496#ent", "pos": [9, 10]}}
{"token": ["In", "the", "course", "of", "characterizing", "C1418627#ent", "<e1>", ",", "we", "discovered", "that", "wild-type", "legionellae", "secrete", "a", "C0023194#ent", "<e2>", "activity", ",", "highlighting", "the", "spectrum", "of", "lipolytic", "enzymes", "produced", "by", "L.", "pneumophila"], "h": {"id": "C1418627", "name": "C1418627#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023194", "name": "C0023194#ent", "pos": [15, 16]}}
{"token": ["The", "most", "potent", "C1413693#ent", "<e1>", "analogues", "to", "displace", "labelled", "C0037956#ent", "<e2>", "from", "DA-2", "receptors", "rat", "striatum", "were", ":", "3-hydroxy-CPZ", ",", "C1413693#ent", "<e1>", ",", "3,7-dihydroxy-CPZ", ",", "and", "7-hydroxy-CPZ", "."], "h": {"id": "C0037956", "name": "C0037956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413693", "name": "C1413693#ent", "pos": [3, 4]}}
{"token": ["Only", "granule", "neurons", ",", "however", ",", "showed", "an", "enhanced", "expression", "of", "both", "mRNA", "and", "protein", "levels", "cyclin", "D1", "the", "presence", "of", "C0085171#ent", "<e1>", "that", "completely", "eliminated", "C2364020#ent", "<e2>"], "h": {"id": "C0085171", "name": "C0085171#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2364020", "name": "C2364020#ent", "pos": [26, 27]}}
{"token": ["To", "improve", "the", "QOL", "in", "C0009324#ent", "<e1>", "patients", ",", "all", "administrated", "C1367452#ent", "<e2>", "must", "be", "tapered", "off", "after", "achieving", "the", "remission", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [11, 12]}}
{"token": ["C2346949#ent", "<e1>", "deficient", "(", "-/-", ")", "mice", "can", "not", "transport", "C3538699#ent", "<e2>", "the", "cell", "surface", "which", "results", "in", "failure", "of", "the", "generation", "of", "CD8+", "T", "cells", "the", "thymus", "."], "h": {"id": "C2346949", "name": "C2346949#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538699", "name": "C3538699#ent", "pos": [10, 11]}}
{"token": ["Five", "paralogous", "Trichomonas", "gene", "products", "Dol-P-Glc", "synthase", "activity", "when", "expressed", "as", "recombinant", "proteins", "and", "these", "Trichomonas", "Alg5s", "correct", "a", "C0003766#ent", "<e1>", "a", "Saccharomyces", "C1426822#ent", "<e2>", "mutant", "in", "vivo"], "h": {"id": "C0003766", "name": "C0003766#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1426822", "name": "C1426822#ent", "pos": [23, 24]}}
{"token": ["Kinetic", "analysis", "that", "intrinsic", "peptidases", "cause", "an", "observed", "first-order", "Sequential", "Multiple-Step", "Reaction", "(", "C1428572#ent", "<e1>", ")", "in", "digestion", "of", "the", "C0030956#ent", "<e2>", "."], "h": {"id": "C1428572", "name": "C1428572#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [20, 21]}}
{"token": ["The", "C0256079#ent", "<e1>", "p300/CBP", ")", "and", "the", "nuclear", "coactivator", "1", "C1705804#ent", "<e2>", ")", ",", "a", "member", "of", "the", "p160/steroid", "receptor", "coactivator", "family", "bind", "independently", "to", "specific", "regions", "of", "the", "STAT6", "transactivation", "domain", "act", "as", "coactivators", "."], "h": {"id": "C0256079", "name": "C0256079#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705804", "name": "C1705804#ent", "pos": [10, 11]}}
{"token": ["The", "C0071505#ent", "<e1>", "and", "polyproline", "tracts", "within", "the", "C0017337#ent", "<e2>", "are", "absent", "in", "Fugu", "rubripes"], "h": {"id": "C0071505", "name": "C0071505#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["C1333337#ent", "<e1>", "ligation", "induces", "C0208355#ent", "<e2>", "degradation", "of", "C1333337#ent", "<e1>", ",", "attenuates", "the", "invasive", "phenotype", ",", "and", "decreases", "both", "FAK", "phosphorylation", "and", "MMP-2", "expression", "."], "h": {"id": "C0208355", "name": "C0208355#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333337", "name": "C1333337#ent", "pos": [0, 1]}}
{"token": ["A", "mouse", "Sin3-related", "protein", "is", "a", "C1336779#ent", "<e1>", "and", "a", "human", "C0768528#ent", "<e2>", "a", "histone", "deacetylase"], "h": {"id": "C1336779", "name": "C1336779#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0768528", "name": "C0768528#ent", "pos": [11, 12]}}
{"token": ["The", "C1336779#ent", "<e1>", "found", "in", "a", "large", "multiprotein", "complex", "the", "histone", "deacetylases", "HDAC1", "and", "C0768528#ent", "<e2>", ",", "in", "addition", "to", "at", "least", "five", "tightly", "associated", "polypeptides", "."], "h": {"id": "C1336779", "name": "C1336779#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0768528", "name": "C0768528#ent", "pos": [14, 15]}}
{"token": ["The", "rubber", "closures", "the", "C0003205#ent", "<e1>", "the", "dilution", "effect", "of", "the", "C3536839#ent", "<e2>", "itself", "accounted", "for", "a", "minor", "part", "of", "the", "inoculum", "reduction", "achieved", "by", "the", "new", "hub", "model", "."], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [4, 5]}, "relation": "therapeutic_class_of", "t": {"id": "C3536839", "name": "C3536839#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "the", "clinical", "features", "of", "contact", "dermatitis", "by", "C0003205#ent", "<e1>", "and", "to", "ascertain", "whether", "the", "substance", "responsible", "is", "the", "C3536839#ent", "<e2>", "itself", "or", "the", "excipients", "."], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [9, 10]}, "relation": "therapeutic_class_of", "t": {"id": "C3536839", "name": "C3536839#ent", "pos": [20, 21]}}
{"token": ["Quality", "of", "life", "C0518214#ent", "<e1>", ")", "assessment", "in", "children", "with", "C0005779#ent", "<e2>", "a", "relatively", "unstudied", "area", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [10, 11]}}
{"token": ["Hypercapnia", "has", "been", "accepted", "during", "nasal", "intermittent", "positive", "pressure", "ventilation", "nIPPV", ")", "and", "during", "subsequent", "spontaneous", "breathing", "patients", "with", "chronic", "hypercapnic", "respiratory", "failure", "C3538773#ent", "<e1>", ")", "due", "to", "C0024117#ent", "<e2>", "."], "h": {"id": "C3538773", "name": "C3538773#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [28, 29]}}
{"token": ["In", "this", "study", ",", "we", "tested", "the", "hypothesis", "that", "chronic", "C3538773#ent", "<e1>", "in", "patients", "with", "C0024117#ent", "<e2>", "is", "associated", "with", "low-frequency", "fatigue", "LFF", ")", "of", "the", "diaphragm", "."], "h": {"id": "C3538773", "name": "C3538773#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [15, 16]}}
{"token": ["The", "mechanism", "responsible", "for", "chronic", "hypercapnic", "respiratory", "failure", "C3538773#ent", "<e1>", ")", "in", "patients", "with", "C0024117#ent", "<e2>", "remains", "unclear", "."], "h": {"id": "C3538773", "name": "C3538773#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [14, 15]}}
{"token": ["C0032302#ent", "<e1>", "necessitates", "ICU", "admission", "to", "C0035222#ent", "<e2>", "in", "approximately", "10", "%", "of", "patients", "."], "h": {"id": "C0032302", "name": "C0032302#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [6, 7]}}
{"token": ["New", "studies", "demonstrate", "that", "patients", "with", "giant", "cell", "arteritis", "C0521516#ent", "<e1>", "rheumatica", "have", "an", "increased", "risk", "of", "C0020676#ent", "<e2>", "."], "h": {"id": "C0521516", "name": "C0521516#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [17, 18]}}
{"token": ["Structural", "features", "the", "predicted", "polypeptide", "include", "an", "amino-terminal", "membrane-targeting", "signal", "sequence", ",", "a", "legume", "lectin-like", "extracellular", "domain", "a", "single", "C1417326#ent", "<e1>", "and", "a", "C0072402#ent", "<e2>"], "h": {"id": "C1417326", "name": "C1417326#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [23, 24]}}
{"token": ["C3887650#ent", "<e1>", "is", "a", "C0011156#ent", "<e2>", "the", "same", "category", "as", "rickets", "."], "h": {"id": "C3887650", "name": "C3887650#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011156", "name": "C0011156#ent", "pos": [4, 5]}}
{"token": ["Another", "candidate", "appeared", "to", "be", "cysteine", ",", "since", "C0885449#ent", "<e1>", "at", "about", "a", "2-fold", "molar", "excess", "inactivated", "C0002272#ent", "<e2>", "by", "modifying", "both", "of", "the", "enzyme", "'s", "cysteine", "residues", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [17, 18]}}
{"token": ["Our", "findings", "confirm", "that", "transient", "relaxation", "of", "the", "LES", "is", "the", "major", "mechanism", "of", "C0017168#ent", "<e1>", "in", "patients", "with", "C0014869#ent", "<e2>"], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014869", "name": "C0014869#ent", "pos": [19, 20]}}
{"token": ["C1826724#ent", "<e1>", "activation", "after", "germinal", "vesicle", "breakdown", "leads", "to", "the", "inhibition", "of", "C0287531#ent", "<e2>", "the", "arrest", "of", "cell", "cycle", "MI", "stage"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0287531", "name": "C0287531#ent", "pos": [12, 13]}}
{"token": ["Age", "and", "degree", "of", "C0178879#ent", "<e1>", "the", "most", "important", "determinants", "of", "the", "risk", "of", "C0442874#ent", "<e2>", "."], "h": {"id": "C0178879", "name": "C0178879#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [14, 15]}}
{"token": ["The", "activities", "of", "C1531131#ent", "<e1>", "aldolase", ",", "phosphoglucomutase", ",", "glutamate-pyruvate", "transaminase", "C0004002#ent", "<e2>", "and", "acetolactate", "synthase", "increased", "from", "1-", "to", "2.5-fold", "with", "increasing", "N", "supply"], "h": {"id": "C1531131", "name": "C1531131#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004002", "name": "C0004002#ent", "pos": [11, 12]}}
{"token": ["Current", "application", "(", "30", "min", ";", "0.5", "mA/cm(2", ")", ")", ",", "with", "a", "donor", "at", "pH", "7.0", ",", "favored", "C0022643#ent", "<e1>", "accumulation", "even", "if", "the", "C0013227#ent", "<e2>", "is", "not", "ionized", "."], "h": {"id": "C0022643", "name": "C0022643#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [25, 26]}}
{"token": ["In", "the", "present", "study", ",", "we", "have", "tested", "that", "C1416801#ent", "<e1>", "can", "alleviate", "insulin", "resistance", "the", "effect", "of", "C1416801#ent", "<e1>", "is", "associated", "with", "cell-surface", "level", "of", "glucose", "transporter", "4", "C2982484#ent", "<e1>", ")", "in", "skeletal", "muscle", "NIDDM", "rats", "."], "h": {"id": "C1416801", "name": "C1416801#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [29, 30]}}
{"token": ["Based", "on", "the", "xanthine-oxygen", "reductase", "activity", "2,2'-azino-di-(3-ethylbenzthiazoline-6-sulfonic", "acid", ")", "C0031179#ent", "<e1>", "activity", ",", "cow's", "milk", "0.45", "microM", "C1421531#ent", "<e2>", "0.32", "microM", "lactoperoxidase", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [17, 18]}}
{"token": ["Little", "is", "known", ",", "however", ",", "about", "the", "changes", "of", "C0010656#ent", "<e1>", "and", "their", "regulatory", "proteins", "C0012772#ent", "<e2>", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012772", "name": "C0012772#ent", "pos": [16, 17]}}
{"token": ["Taken", "together", ",", "these", "results", "indicate", "that", "RZ-3", "and", "C1822726#ent", "<e1>", "are", "biologically", "active", "D-amino", "acid-containing", "C0030956#ent", "<e2>", "that", "can", "themselves", "support", "tumor", "cell", "adhesion", "can", "inhibit", "tumor", "cell", "adhesion", "immobilized", "ECM", "proteins", "or", "dermal", "fibroblasts"], "h": {"id": "C1822726", "name": "C1822726#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}}
{"token": ["Azodisalicylate", "(", "ADS", ")", "is", "one", "of", "the", "possible", "successors", "of", "C0036078#ent", "<e1>", "in", "the", "treatment", "of", "C0009324#ent", "<e2>"], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [17, 18]}}
{"token": ["Blepharophimosis/ptosis/epicanthus", "inversus", "syndrome", "BPES", ")", ",", "an", "C0265336#ent", "<e1>", "which", "eyelid", "malformation", "associated", "with", "type", "I", "BPES", "or", "without", "premature", "ovarian", "failure", "C2700050#ent", "<e2>", "."], "h": {"id": "C0265336", "name": "C0265336#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2700050", "name": "C2700050#ent", "pos": [22, 23]}}
{"token": ["Improved", "hemodynamic", "effects", "and", "the", "good", "safety/acceptability", "of", "the", "drug", "indicate", "that", "C0600487#ent", "<e1>", "is", "a", "treatment", "of", "choice", "in", "C0018802#ent", "<e2>"], "h": {"id": "C0600487", "name": "C0600487#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["ACK1", "(", "activated", "C1449330#ent", "<e1>", "is", "a", "C1540033#ent", "<e2>", "the", "only", "tyrosine", "kinase", "to", "interact", "with", "Cdc42", "."], "h": {"id": "C1449330", "name": "C1449330#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1540033", "name": "C1540033#ent", "pos": [7, 8]}}
{"token": ["In", "this", "report", ",", "we", "show", "that", "the", "C1449330#ent", "<e1>", "isoform", "of", "C1540033#ent", "<e2>", "plays", "a", "critical", "role", "in", "transducing", "Ras-Cdc42", "signals", "in", "the", "NIH", "3T3", "cells"], "h": {"id": "C1449330", "name": "C1449330#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1540033", "name": "C1540033#ent", "pos": [12, 13]}}
{"token": ["A", "missense", "mutation", "in", "the", "C1367553#ent", "<e1>", "found", "in", "13", "of", "the", "15", "propositi", "with", "C0398621#ent", "<e2>", ",", "in", "one", "of", "these", "in", "a", "homozygous", "manner", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0398621", "name": "C0398621#ent", "pos": [15, 16]}}
{"token": ["A", "probable", "link", "between", "C1367553#ent", "<e1>", "and", "ligneous", "conjunctivitis", "been", "indicated", "by", "the", "recent", "diagnoses", "of", "C0398621#ent", "<e2>", "five", "patients", "suffering", "from", "ligneous", "conjunctivitis"], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0398621", "name": "C0398621#ent", "pos": [16, 17]}}
{"token": ["Fibrinogen-deficient", "mice", "also", "deficient", "for", "C1367553#ent", "<e1>", "do", "not", "develop", "the", "pathology", "typical", "of", "C0398621#ent", "<e2>"], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0398621", "name": "C0398621#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "the", "K19E", "mutation", "in", "the", "C1367553#ent", "<e1>", "a", "common", "cause", "of", "C0398621#ent", "<e2>", "in", "Scotland", ",", "with", "an", "estimated", "prevalence", "of", "around", "0.14", "%", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0398621", "name": "C0398621#ent", "pos": [14, 15]}}
{"token": ["Infection", "occurs", "mainly", "in", "keratinized", "tissues", "and", "it", "is", "necessary", "for", "the", "organism", "to", "produce", "and", "excrete", "C0596543#ent", "<e1>", "which", "are", "able", "to", "degrade", "C0022564#ent", "<e2>", "."], "h": {"id": "C0596543", "name": "C0596543#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0022564", "name": "C0022564#ent", "pos": [24, 25]}}
{"token": ["Kinetic", "properties", "the", "C0017933#ent", "<e1>", "that", "the", "enzyme", "is", "always", "activated", "by", "C0017755#ent", "<e2>", ",", "although", "the", "degree", "of", "activation", "by", "C0017755#ent", "<e2>", "was", "found", "to", "be", "somewhat", "variable", "."], "h": {"id": "C0017933", "name": "C0017933#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "C0017933#ent", "<e1>", "decreased", "the", "apparent", "Ka", "for", "C0017755#ent", "<e2>", "."], "h": {"id": "C0017933", "name": "C0017933#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [9, 10]}}
{"token": ["The", "early", "foci", "12", "weeks", ")", "showed", "no", "change", "in", "the", "levels", "of", "glycogen", "phosphorylase", "C0017933#ent", "<e1>", "a", "strong", "reduction", "of", "C0017755#ent", "<e2>", ",", "and", "a", "high", "increase", "in", "glucose-6-phosphate", "dehydrogenase"], "h": {"id": "C0017933", "name": "C0017933#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [21, 22]}}
{"token": ["When", "1", "%", "(", "w/v", ")", "of", "C1412332#ent", "<e1>", "was", "added", "to", "the", "perfusion", "fluid", "even", "C3474940#ent", "<e2>", "had", "no", "effect", "the", "tubular", "transport", "Na+", ",", "glucose", "and", "water", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3474940", "name": "C3474940#ent", "pos": [16, 17]}}
{"token": ["The", "in", "vitro", "activities", "of", "ketoconazole", ",", "C0546862#ent", "<e1>", ",", "miconazole", ",", "and", "C0216194#ent", "<e2>", "54", "Malassezia", "isolates", "were", "determined", "by", "agar", "and", "broth", "dilution", "methods"], "h": {"id": "C0546862", "name": "C0546862#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0216194", "name": "C0216194#ent", "pos": [13, 14]}}
{"token": ["When", "intracellular", "redox", "state", "changed-by", "inhibition", "of", "11beta", "HSD2", ",", "generation", "of", "reactive", "oxygen", "species", "or", "intracellular", "introduction", "of", "C0061516#ent", "<e1>", "changes", "from", "an", "MR", "antagonist", "an", "C2987634#ent", "<e2>"], "h": {"id": "C0061516", "name": "C0061516#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [27, 28]}}
{"token": ["C1137428#ent", "<e1>", "has", "been", "widely", "used", "for", "treatment", "of", "C0002986#ent", "<e2>", "its", "approval", "by", "the", "U.S.", "Food", "and", "Drug", "Administration", "2003", "."], "h": {"id": "C1137428", "name": "C1137428#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002986", "name": "C0002986#ent", "pos": [9, 10]}}
{"token": ["On", "the", "other", "hand", ",", "C1413900#ent", "<e1>", "and", "interleukin-1", "beta-converting", "enzyme", "ICE", ")", "were", "downregulated", "while", "C1332397#ent", "<e2>", "and", "Ich-1s", "were", "upregulated", "."], "h": {"id": "C1413900", "name": "C1413900#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [16, 17]}}
{"token": ["The", "resistance", "of", "adult", "mice", "to", "C0149512#ent", "<e1>", "murine", "cytomegalovirus", "controlled", "by", "C1417679#ent", "<e2>", "linked", "to", "the", "H-2", "complex", "."], "h": {"id": "C0149512", "name": "C0149512#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Expression", "of", "the", "type", "III", "secretion", "system", "T3SS", ")", "proteins", "is", "correlated", "with", "virulence", "in", "models", "of", "C0149512#ent", "<e1>", "while", "downregulation", "of", "the", "T3SS", "and", "upregulation", "of", "C1417679#ent", "<e2>", "important", "for", "biofilm", "formation", "observed", "during", "chronic", "infections"], "h": {"id": "C0149512", "name": "C0149512#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [27, 28]}}
{"token": ["The", "putative", "human", "and", "mouse", "C1439347#ent", "<e1>", "100", "%", "identical", ";", "the", "chicken", "C2698901#ent", "<e2>", "cDNA", "contains", "an", "open", "reading", "frame", "170", "amino", "acids", "a", "91", "%", "identity", "to", "its", "human", "and", "murine", "counterparts", "."], "h": {"id": "C1439347", "name": "C1439347#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2698901", "name": "C2698901#ent", "pos": [13, 14]}}
{"token": ["C0878682#ent", "<e1>", "is", "an", "autosomal", "recessive", "disorder", "iron", "metabolism", "originally", "called", "familial", "apoceruloplasmin", "deficiency", "which", "manifests", "C0005747#ent", "<e2>", "retinal", "degeneration"], "h": {"id": "C0878682", "name": "C0878682#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0005747", "name": "C0005747#ent", "pos": [16, 17]}}
{"token": ["Attenuation", "of", "lipopolysaccharide-", "and", "TNF-induced", "release", "of", "prostaglandin", "E2", "cultured", "macrophage", "cells", "P-NT.II", "suggests", "that", "the", "peptide", "may", "influence", "the", "prostaglandin-mediated", "inflammatory", "response", "C0038013#ent", "<e1>", "limiting", "the", "bioavailability", "of", "arachidonic", "acid", "C1418616#ent", "<e2>", "inhibition", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1418616", "name": "C1418616#ent", "pos": [31, 32]}}
{"token": ["Since", "the", "cloning", "of", "the", "type", "II", "C1418616#ent", "<e1>", "in", "1989", "from", "C0038013#ent", "<e2>", "synovial", "fluid", "a", "direct", "or", "indirect", "participation", "of", "type", "II", "C1418616#ent", "<e1>", "in", "the", "production", "of", "lipid", "mediators", "been", "purposed", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418616", "name": "C1418616#ent", "pos": [7, 8]}}
{"token": ["A", "C3653457#ent", "<e1>", "Hoechst", "33258", "induce", "decondensation", "of", "constitutive", "C0082874#ent", "<e2>", "in", "the", "mouse", "derived", "L", "cell", "chromosomes", "the", "compound", "is", "given", "in", "sufficiently", "high", "concentration", "(", "40", "micrograms/ml", ")", "to", "the", "L", "cell", "culture"], "h": {"id": "C3653457", "name": "C3653457#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0082874", "name": "C0082874#ent", "pos": [9, 10]}}
{"token": ["The", "activation", "of", "JNK1", "and", "the", "transactivation", "of", "C0162508#ent", "<e1>", "by", "this", "mutant", "of", "C4084713#ent", "<e2>", "were", "inhibited", "by", "a", "dominant", "negative", "MEKK1", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4084713", "name": "C4084713#ent", "pos": [14, 15]}}
{"token": ["C1412058#ent", "<e1>", "TD", ")", "is", "a", "rare", "familial", "disorder", "mutations", "in", "the", "C3711161#ent", "<e2>", "ABCA1", ")", "gene", "."], "h": {"id": "C1412058", "name": "C1412058#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3711161", "name": "C3711161#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "the", "Ca(2+)/calmodulin", "signalling", "pathway", "via", "C0907533#ent", "<e1>", "active", "CaMKIV", "prevents", "nuclear", "entry", "C0910119#ent", "<e2>", "and", "HDAC4-mediated", "inhibition", "of", "differentiation", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0910119", "name": "C0910119#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "small", "amounts", "C1723257#ent", "<e1>", ",", "a", "peroxynitrite", "generator", "caused", "a", "concentration-dependent", "inhibition", "of", "C3813543#ent", "<e2>", "by", "IL-8", "."], "h": {"id": "C1723257", "name": "C1723257#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3813543", "name": "C3813543#ent", "pos": [16, 17]}}
{"token": ["Insulin", "both", "augmented", "C3538853#ent", "<e1>", "phosphorylation", "and", "synergized", "with", "C3541395#ent", "<e2>", "in", "stimulating", "Na+", "transport"], "h": {"id": "C3538853", "name": "C3538853#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541395", "name": "C3541395#ent", "pos": [9, 10]}}
{"token": ["C3540800#ent", "<e1>", "was", "administered", "as", "the", "C0007026#ent", "<e2>", "to", "6", "psychiatrically", "normal", "subjects", "11", "days", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007026", "name": "C0007026#ent", "pos": [6, 7]}}
{"token": ["C3540800#ent", "<e1>", "in", "the", "form", "of", "the", "C0007026#ent", "<e2>", "or", "citrate", "salts", "been", "used", "by", "Cade", "in", "1949", "for", "the", "treatment", "of", "affective", "disorders"], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007026", "name": "C0007026#ent", "pos": [7, 8]}}
{"token": ["The", "C0472817#ent", "<e1>", "a", "rare", ",", "autosomal", "dominant", "primary", "immunodeficiency", "disorder", "by", "warts", ",", "C0086438#ent", "<e2>", ",", "recurrent", "infections", "and", "myelocathexis", "."], "h": {"id": "C0472817", "name": "C0472817#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0086438", "name": "C0086438#ent", "pos": [14, 15]}}
{"token": ["C0472817#ent", "<e1>", "a", "rare", "congenital", "familial", "syndrome", "of", "warts", ",", "C0086438#ent", "<e2>", ",", "infections", ",", "and", "myelokathexis", "."], "h": {"id": "C0472817", "name": "C0472817#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0086438", "name": "C0086438#ent", "pos": [10, 11]}}
{"token": ["The", "projections", "of", "brainstem", "catecholaminergic", "(", "CA", ")", "cell", "groups", "the", "rat", "nucleus", "tractus", "solitarius", "C1417869#ent", "<e1>", ")", "were", "examined", "using", "C0085196#ent", "<e2>", "(", "6-OHDA", ")", "injections", "and", "glass", "microknife", "cuts", "."], "h": {"id": "C1417869", "name": "C1417869#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085196", "name": "C0085196#ent", "pos": [21, 22]}}
{"token": ["Smoking", "habits", "no", "differentiating", "effect", "on", "the", "functional", "activity", "of", "C0033607#ent", "<e1>", "alpha", "1PI", ")", "in", "the", "serum", "and", "bronchoalveolar", "lavage", "fluid", "C1704942#ent", "<e2>", ")", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [22, 23]}}
{"token": ["We", "examined", "whether", "measurable", "activities", "of", "C0391845#ent", "<e1>", "present", "in", "equine", "plasma", "and", "whether", "the", "C4025182#ent", "<e2>", "changes", "in", "the", "muscle", "are", "reflected", "in", "plasma", "."], "h": {"id": "C0391845", "name": "C0391845#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4025182", "name": "C4025182#ent", "pos": [15, 16]}}
{"token": ["Examination", "of", "the", "substrate", "specificity", "of", "the", "C3537377#ent", "<e1>", "that", "the", "C0027203#ent", "<e2>", "preferred", "basic", "proteins", "as", "substrates", "."], "h": {"id": "C3537377", "name": "C3537377#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["In", "previous", "study", "we", "showed", "the", "antagonist", "role", "of", "the", "two", "morphogenetic", "hormones", ",", "juvenile", "hormone", "C3811152#ent", "<e1>", ")", "and", "ecdysone", ",", "on", "the", "regulation", "of", "adult", "C1417048#ent", "<e2>", "neurogenesis", "in", "vivo"], "h": {"id": "C3811152", "name": "C3811152#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [27, 28]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "polycyclic", "aromatic", "adducts", "in", "78", "breast", "cancer", "patients", "and", "C1332629#ent", "<e1>", "patients", "with", "lifetime", "environmental", "exposure", "to", "polycyclic", "aromatic", "hydrocarbon", "C1418251#ent", "<e2>", ")", "compounds", "."], "h": {"id": "C1332629", "name": "C1332629#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418251", "name": "C1418251#ent", "pos": [26, 27]}}
{"token": ["The", "author", "discusses", "the", "differential", "diagnosis", "bilateral", "facial", "nerve", "paralysis", "included", "several", "C0012634#ent", "<e1>", "and", "syndromes", "and", "concludes", "by", "C0038366#ent", "<e2>", "aetiology", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038366", "name": "C0038366#ent", "pos": [19, 20]}}
{"token": ["As", "efforts", "to", "understand", "complex", "C0019247#ent", "<e1>", "expanded", "to", "different", "continental", "populations", "the", "understanding", "of", "C1517495#ent", "<e2>", "these", "continents", "will", "be", "useful", "in", "design", "and", "execution", "of", "association", "tests"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1517495", "name": "C1517495#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "the", "zwitterionic", "and", "biomimetic", "nature", "of", "C1450334#ent", "<e1>", "and", "the", "ease", "of", "C1705240#ent", "<e2>", "preparation", "make", "SBMA-based", "materials", "very", "attractive", "for", "a", "wide", "range", "of", "applications", "."], "h": {"id": "C1450334", "name": "C1450334#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [14, 15]}}
{"token": ["Four", "of", "these", "phage", "clones", "express", "in", "bacteria", "a", "polypeptide", "antigenically", "to", "an", "18", "kDa", "subunit", "(", "C1539001#ent", "<e1>", ")", "of", "the", "yeast", "C0018437#ent", "<e2>"], "h": {"id": "C1539001", "name": "C1539001#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0018437", "name": "C0018437#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "C1415169#ent", "<e1>", "GnRH", ")", "and", "GnRH-associated", "peptide", "C2984552#ent", "<e2>", ")", "on", "cytosolic", "free", "calcium", "concentration", "[Ca(2+)](i", ")", ")", "were", "investigated", "in", "20", "human", "nonfunctioning", "pituitary", "adenomas"], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2984552", "name": "C2984552#ent", "pos": [10, 11]}}
{"token": ["The", "incapacity", "of", "C0175697#ent", "<e1>", "to", "drive", "HIV-1", "production", "in", "C1539788#ent", "<e2>", "was", "not", "due", "to", "its", "inability", "to", "activate", "the", "ubiquitous", "transcription", "factor", "NF-kappaB", "in", "virus-infected", "cells", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539788", "name": "C1539788#ent", "pos": [10, 11]}}
{"token": ["Possible", "targets", "for", "C1412228#ent", "<e1>", "and", "glutamate", "are", "the", "recently", "identified", "clock", "genes", "Per1", "and", "C1416526#ent", "<e2>", ",", "which", "are", "induced", "in", "the", "SCN", "by", "light", ",", "glutamate", "and", "C1412228#ent", "<e1>", "at", "night", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416526", "name": "C1416526#ent", "pos": [15, 16]}}
{"token": ["C0015137#ent", "<e1>", "provides", "another", "option", "in", "the", "treatment", "of", "C0033860#ent", "<e2>", "."], "h": {"id": "C0015137", "name": "C0015137#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [9, 10]}}
{"token": ["C0015137#ent", "<e1>", "is", "particularly", "effective", "in", "disorders", "of", "keratinisation", "(", "C0033860#ent", "<e2>", ",", "ichthyosis", ")", "whereas", "isotretinoin", "is", "the", "best", "known", "therapy", "of", "severe", "acne", "."], "h": {"id": "C0015137", "name": "C0015137#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [10, 11]}}
{"token": ["Alternatively", ",", "alpha4beta1-stimulated", "C0919442#ent", "<e1>", "cell", "motility", "is", "dependent", "upon", "Src", "and", "p130Cas", "but", "C0059239#ent", "<e2>", "is", "not", "essential", "."], "h": {"id": "C0919442", "name": "C0919442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [14, 15]}}
{"token": ["shRNA", "knockdown", "revealed", "that", "alpha5beta1-stimulated", "C0919442#ent", "<e1>", "motility", "is", "dependent", "upon", "C0059239#ent", "<e2>", "FAK", ")", "PTK", ",", "Src", "PTK", "and", "p130Cas", "adapter", "protein", "expression", "."], "h": {"id": "C0919442", "name": "C0919442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [11, 12]}}
{"token": ["shRNA", "knockdown", "revealed", "that", "alpha5beta1-stimulated", "C0919442#ent", "<e1>", "motility", "is", "dependent", "upon", "focal", "adhesion", "kinase", "C0059239#ent", "<e2>", ")", "PTK", ",", "Src", "PTK", "and", "p130Cas", "adapter", "protein", "expression", "."], "h": {"id": "C0919442", "name": "C0919442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [14, 15]}}
{"token": ["Cells", "in", "the", "normal", "rib", "adjacent", "to", "the", "C0151846#ent", "<e1>", "also", "express", "C3853624#ent", "<e2>", "suggesting", "that", "transgene", "expression", "is", "correctly", "targeted", "to", "generate", "osteosarcomas", "."], "h": {"id": "C0151846", "name": "C0151846#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3853624", "name": "C3853624#ent", "pos": [12, 13]}}
{"token": ["The", "results", "of", "this", "small", "open-label", "extension", "study", "that", "patients", "with", "C0014547#ent", "<e1>", "were", "successfully", "converted", "to", "long-term", "C0068897#ent", "<e2>", "monotherapy", "demonstrated", "no", "adverse", "effects", "cognitive", "function", "mood", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0068897", "name": "C0068897#ent", "pos": [18, 19]}}
{"token": ["To", "report", "3", "cases", "with", "C0014547#ent", "<e1>", "had", "non-convulsive", "status", "epilepticus", "NCSE", ")", "induced", "by", "treatment", "with", "C0068897#ent", "<e2>", "(", "TGB", ")", "and", "review", "the", "previously", "published", "cases", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0068897", "name": "C0068897#ent", "pos": [17, 18]}}
{"token": ["A", "case", "of", "nephrotic", "syndrome", "C3854173#ent", "<e1>", "a", "74-year-old", "man", "with", "C1260915#ent", "<e2>", "described", "."], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1260915", "name": "C1260915#ent", "pos": [11, 12]}}
{"token": ["These", "genes", "encode", "C0086376#ent", "<e1>", "that", "regulate", "DNA", "methylation", "C2697959#ent", "<e2>", ")", ",", "modify", "histones", "(", "RSK2", "and", "JARID1C", ")", ",", "and", "remodel", "nucleosomes", "through", "ATP", "hydrolysis", "(", "ATRX", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697959", "name": "C2697959#ent", "pos": [9, 10]}}
{"token": ["This", "study", "confirmed", "that", "C0006462#ent", "<e1>", "was", "as", "effective", "as", "C0024002#ent", "<e2>", "at", "D56", "in", "monitored", "outpatients", "with", "generalized", "anxiety", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [10, 11]}}
{"token": ["We", "observed", "that", "C0812246#ent", "<e1>", "exposure", "increased", "C1421168#ent", "<e2>", "expression", "without", "significantly", "altering", "expression", "of", "other", "TRPC", "isoforms", "in", "human", "pulmonary", "artery", "endothelial", "cells", "HPAEC", ")", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421168", "name": "C1421168#ent", "pos": [7, 8]}}
{"token": ["We", "determined", "the", "effects", "of", "C0812246#ent", "<e1>", "on", "the", "expression", "of", "C1421168#ent", "<e2>", "TRPC", ")", "homologues", "in", "human", "vascular", "endothelial", "cells", "the", "consequences", "of", "TRPC", "expression", "on", "the", "endothelial", "permeability", "response", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421168", "name": "C1421168#ent", "pos": [11, 12]}}
{"token": ["Some", "other", "C0009450#ent", "<e1>", "as", "LaCrosse", "encephalitis", "Lyme", "disease", "caused", "by", "C0035064#ent", "<e2>", "closely", "dependent", "on", "the", "integrity", "of", "their", "environment", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["Tumor", "necrosis", "factor-alpha", "TNF-alpha", ")", "inhibitors", "have", "been", "used", "in", "the", "treatment", "of", "C1419789#ent", "<e1>", ",", "which", "is", "associated", "with", "C3714619#ent", "<e2>"], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3714619", "name": "C3714619#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "tankyrase-2", "associates", "and", "co-localizes", "with", "C1336654#ent", "<e1>", ",", "suggesting", "that", "both", "C0963182#ent", "<e2>", "might", "function", "as", "a", "complex", "."], "h": {"id": "C1336654", "name": "C1336654#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0963182", "name": "C0963182#ent", "pos": [13, 14]}}
{"token": ["TNF-alpha", "and", "IL-6", "secretion", "from", "the", "cells", "was", "altered", "with", "beta(2)-adrenoceptor", "agonists", "terbutaline", ",", "C0969589#ent", "<e1>", ")", "and", "angiotensin", "II", "to", "changes", "of", "TNF-alpha", "and", "IL-6", "C0812327#ent", "<e2>"], "h": {"id": "C0969589", "name": "C0969589#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [26, 27]}}
{"token": ["In", "S.", "cerevisiae", "C0017337#ent", "<e1>", "complementing", "five", "mutants", "of", "the", "RAD3", "epistasis", "group", ",", "C1867391#ent", "<e2>", ",", "rad2", ",", "rad3", ",", "rad4", "and", "rad10", "have", "been", "cloned", "and", "analyzed", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1867391", "name": "C1867391#ent", "pos": [14, 15]}}
{"token": ["Activity", "profiles", "C0014442#ent", "<e1>", "extracted", "from", "the", "fraction", "C1334134#ent", "<e2>", "at", "100000", "g", "showed", "heterogeneity", "after", "isopycnic", "centrifugation", "CsCl", "gradients", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334134", "name": "C1334134#ent", "pos": [8, 9]}}
{"token": ["We", "cloned", "and", "characterized", "a", "RAD52", "homolog", "Kluyveromyces", "lactis", "partially", "complemented", "S.", "cerevisiae", "C1419243#ent", "<e1>", "mutants", "while", "exhibiting", "negative", "dominance", "in", "C2987364#ent", "<e2>", "(", "RAD52", ")", "strains", "."], "h": {"id": "C1419243", "name": "C1419243#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [21, 22]}}
{"token": ["Extracts", "prepared", "from", "rad50", ",", "C1419243#ent", "<e1>", "or", "rad54", "disruption", "mutants", "all", "have", "reduced", "recombinational", "activity", "to", "C2987364#ent", "<e2>", "."], "h": {"id": "C1419243", "name": "C1419243#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [17, 18]}}
{"token": ["An", "AFLP", "genotype", ",", "termed", "C0812215#ent", "<e1>", ",", "was", "predominant", "in", "C1875400#ent", "<e2>", "from", "both", "patients", "(", "40.5", "%", ")", "and", "water", "(", "49.0", "%", ")", "."], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "these", "results", "indicate", "that", "in", "a", "mouse", "model", "subtotal", "renal", "ablation", "C1565860#ent", "<e1>", "inhibition", "blocks", "expression", "of", "mediators", "of", "C0041349#ent", "<e2>"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041349", "name": "C0041349#ent", "pos": [21, 22]}}
{"token": ["Thirty", "infants", "were", "included", "in", "the", "study", ":", "22", "received", "C0023660#ent", "<e1>", ",", "and", "8", "received", "C0026056#ent", "<e2>", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [16, 17]}}
{"token": ["To", "develop", "a", "high-performance", "liquid", "chromatography", "HPLC", ")", "assay", "for", "C0700480#ent", "<e1>", "in", "feline", "plasma", "and", "determine", "the", "pharmacokinetics", "of", "C0700480#ent", "<e1>", "in", "healthy", "cats", "oral", "administration", "a", "single", "dose", "5", "mg", ")", "of", "C0700480#ent", "<e1>"], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0700480", "name": "C0700480#ent", "pos": [10, 11]}}
{"token": ["DNA", "polymerase", "gamma", "purified", "from", "fetal", "bovine", "C0023899#ent", "<e1>", ",", "replicated", "virion", "single-stranded", "DNA", "C0276275#ent", "<e2>", "a", "unit-length", "double-stranded", "DNA", "molecule", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0276275", "name": "C0276275#ent", "pos": [14, 15]}}
{"token": ["An", "insertion", "mutant", "of", "C1418237#ent", "<e1>", "(", "pTC2/81", ")", "carrying", "a", "copy", "of", "was", "transferred", "to", "C1335807#ent", "<e2>", "conjugation", "."], "h": {"id": "C1418237", "name": "C1418237#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335807", "name": "C1335807#ent", "pos": [16, 17]}}
{"token": ["We", "therefore", "investigated", "the", "role", "of", "the", "GTPase", "C1419227#ent", "<e1>", "which", "modulates", "ROS", "production", "in", "the", "pathway", "leading", "to", "C1958958#ent", "<e2>", "and", "PAI-1", "induction", "."], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1958958", "name": "C1958958#ent", "pos": [19, 20]}}
{"token": ["Spontaneous", "resolution", "of", "the", "severe", "C0427055#ent", "<e1>", "occurred", "when", "teniposide", "was", "substituted", "for", "C0042679#ent", "<e2>", "in", "the", "chemotherapy", "regimen", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [13, 14]}}
{"token": ["Although", "C0427055#ent", "<e1>", "improved", "after", "the", "discontinuation", "of", "C0042679#ent", "<e2>", ",", "other", "symptoms", "suggestive", "of", "a", "neuropathy", "persisted", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [8, 9]}}
{"token": ["Self-destruction", "of", "collagen", "matrices", "rapidly", "in", "resin-infiltrated", "dentin", "in", "vivo", "may", "be", "arrested", "with", "the", "use", "of", "C0008196#ent", "<e1>", "as", "an", "C0919336#ent", "<e2>", "inhibitor", "."], "h": {"id": "C0008196", "name": "C0008196#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [21, 22]}}
{"token": ["It", "is", "believed", "that", "QDCC", "could", "decrease", "the", "EKC", "in", "C3890176#ent", "<e1>", "patient", "and", "this", "effect", "probably", "was", "mediated", "by", "inhibiting", "C0079068#ent", "<e2>", "expression", "."], "h": {"id": "C3890176", "name": "C3890176#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [21, 22]}}
{"token": ["C0206414#ent", "<e1>", "transgenic", "tobacco", "demonstrated", "that", "C3815277#ent", "<e2>", "can", "functionally", "replace", "the", "as-1-like", "element", "in", "the", "PR-1a", "promoter", "in", "response", "to", "all", "stimuli", "."], "h": {"id": "C0206414", "name": "C0206414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3815277", "name": "C3815277#ent", "pos": [6, 7]}}
{"token": ["The", "prodrugs", "cyclophosphamide", "CP", ")", "and", "C0020823#ent", "<e1>", "(", "IF", ")", "are", "oxidized", "by", "hepatic", "cytochrome", "P450", "C0534137#ent", "<e2>", ")", "to", "the", "active", "cytotoxic", "species", "phosphoramide", "mustard"], "h": {"id": "C0020823", "name": "C0020823#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [17, 18]}}
{"token": ["Here", ",", "we", "examined", "the", "effects", "of", "4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio", "]", "acetic", "acid", "Wy-14,643", ")", ",", "a", "peroxisome", "proliferator", "on", "cell", "proliferation", "C1524023#ent", "<e1>", "mRNA", "levels", "in", "the", "C0023899#ent", "<e2>", "of", "rats", "after", "stimulation", "of", "compensative", "cell", "proliferation"], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [26, 27]}}
{"token": ["We", "have", "previously", "shown", "that", "systemically", "injected", "hepatocyte", "growth", "factor", "C1524023#ent", "<e1>", ")", "is", "primarily", "taken", "up", "by", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}}
{"token": ["Before", "intake", "of", "C0003211#ent", "<e1>", "and", "triptans", ",", "oral", "metoclopramide", "or", "C0013015#ent", "<e2>", "is", "recommended", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013015", "name": "C0013015#ent", "pos": [11, 12]}}
{"token": ["C0004364#ent", "<e1>", "a", "class", "of", "C0021053#ent", "<e2>", "characterized", "by", "loss", "of", "tolerance", "self-antigens", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [5, 6]}}
{"token": ["This", "antiviral", "drug", "induce", "or", "exacerbate", "a", "multitude", "of", "C0004364#ent", "<e1>", "however", ",", "clinically", "overt", "C0021053#ent", "<e2>", "rare", "and", "affect", "a", "subset", "of", "subjects", "who", "have", "an", "underlying", "autoimmune", "diathesis"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [15, 16]}}
{"token": ["The", "C1335440#ent", "<e1>", "expressed", "by", "cotransfection", "of", "the", "C3811771#ent", "<e2>", "cDNAs", ",", "one", "of", "which", "fused", "to", "the", "tandem-affinity", "purification", "TAP", ")", "tag", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811771", "name": "C3811771#ent", "pos": [8, 9]}}
{"token": ["Bbp1p", "was", "detected", "at", "the", "central", "plaque", "periphery", "of", "the", "C1442757#ent", "<e1>", "and", "C1708284#ent", "<e2>", "-", "1", "cells", "were", "found", "to", "be", "defective", "in", "C1442757#ent", "<e1>", "duplication", "."], "h": {"id": "C1708284", "name": "C1708284#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1442757", "name": "C1442757#ent", "pos": [10, 11]}}
{"token": ["The", "responses", "to", "NA", "were", "completely", "blocked", "by", "C0733398#ent", "<e1>", ",", "but", "were", "potentiated", "by", "C0018318#ent", "<e2>", ",", "desipramine", "and", "reserpine", "pretreatment", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018318", "name": "C0018318#ent", "pos": [15, 16]}}
{"token": ["Shooting", "pain", "perceived", "in", "trigeminal", ",", "intercostal", ",", "and", "other", "neuralgias", ",", "as", "a", "consequence", "of", "C0009450#ent", "<e1>", "as", "herpes", "zoster", "and", "in", "the", "course", "of", "C0206247#ent", "<e2>", "of", "various", "causes", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0206247", "name": "C0206247#ent", "pos": [26, 27]}}
{"token": ["However", ",", "C0040034#ent", "<e1>", "was", "not", "reversed", "by", "C0270221#ent", "<e2>", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0270221", "name": "C0270221#ent", "pos": [8, 9]}}
{"token": ["A", "46", "year", "old", "woman", "was", "admitted", "to", "our", "institute", "in", "June", ",", "1987", "with", "an", "attack", "of", "asthma", ",", "as", "well", "as", "C0239575#ent", "<e1>", "leukocytosis", "accompanied", "by", "C0745091#ent", "<e2>", "."], "h": {"id": "C0239575", "name": "C0239575#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0745091", "name": "C0745091#ent", "pos": [28, 29]}}
{"token": ["HLA-DR", "gene", "frequencies", "59", "Japanese", "children", "with", "juvenile", "rheumatoid", "arthritis", "C3714757#ent", "<e1>", ")", "and", "62", "Japanese", "adults", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "were", "analyzed", "by", "oligonucleotide", "DNA", "typing"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [20, 21]}}
{"token": ["In", "response", "to", "ligand-receptor", "interaction", ",", "these", "C1336653#ent", "<e1>", "rapidly", "phosphorylated", "and", "activated", ",", "triggering", "tyrosine", "phosphorylation", "activation", "of", "C1332447#ent", "<e2>", "intermediates", "."], "h": {"id": "C1336653", "name": "C1336653#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [19, 20]}}
{"token": ["C0014479#ent", "<e1>", "and", "its", "C0949738#ent", "<e2>", "are", "used", "for", "the", "treatment", "of", "asthma", ",", "nasal", "congestion", "and", "obesity", "."], "h": {"id": "C0014479", "name": "C0014479#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0949738", "name": "C0949738#ent", "pos": [4, 5]}}
{"token": ["Dietary", "supplements", "C0014479#ent", "<e1>", "and", "other", "C0949738#ent", "<e2>", "related", "to", "C0014479#ent", "<e1>", "are", "largely", "consumed", "in", "various", "countries", ",", "with", "the", "purpose", "of", "energetic", "stimulation", "and", "weight", "loss"], "h": {"id": "C0014479", "name": "C0014479#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0949738", "name": "C0949738#ent", "pos": [6, 7]}}
{"token": ["A", "double-blind", "crossover", "study", "ibuprofen", "and", "C0004057#ent", "<e1>", "carried", "out", "in", "27", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["The", "more", "widespread", "and", "appropriate", "use", "of", "C0004057#ent", "<e1>", "in", "patients", "with", "C0003873#ent", "<e2>", "avoid", "many", "premature", "deaths", "secondary", "prevention", "CVD", "and", "first", "myocardial", "infarctions", "primary", "prevention"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}}
{"token": ["This", "study", "tested", "whether", "C0242948#ent", "<e1>", "stimulate", "spinal", "release", "the", "C0243051#ent", "<e2>", "norepinephrine", "either", "by", "direct", "actions", "on", "noradrenergic", "terminals", "or", "indirectly", "by", "stimulating", "release", "of", "other", "neurotransmitters", "to", "induce", "norepinephrine", "release", "."], "h": {"id": "C0242948", "name": "C0242948#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [10, 11]}}
{"token": ["Additional", "receptor", "and", "C0387990#ent", "<e1>", "mechanisms", "of", "cannabinoid", "drugs", "pertinent", "activity", ",", "including", "anti-carcinogenesis", "and", "C0242912#ent", "<e2>", ",", "that", "may", "be", "of", "key", "importance", "in", "aging", "and", "terminal", "patient", "populations", "."], "h": {"id": "C0387990", "name": "C0387990#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [15, 16]}}
{"token": ["The", "mutation", "frequencies", "in", "the", "C0268615#ent", "<e1>", ",", "prothrombin", "and", "FV", "genes", "in", "C3890018#ent", "<e2>", "patients", "did", "not", "differ", "from", "those", "in", "controls", "."], "h": {"id": "C0268615", "name": "C0268615#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [13, 14]}}
{"token": ["Urate", "excretion", "minimally", "suppressed", "by", "pyrazinamide", "and", "minimally", "increased", "after", "administration", "of", "C0033209#ent", "<e1>", ",", "whereas", "it", "decreased", "after", "administration", "of", "C0005035#ent", "<e2>", "."], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0005035", "name": "C0005035#ent", "pos": [21, 22]}}
{"token": ["An", "unusual", "case", "of", "WM", "who", "developed", "C1704321#ent", "<e1>", "to", "immunologically", "mediated", "C0866112#ent", "<e2>", "described", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0866112", "name": "C0866112#ent", "pos": [12, 13]}}
{"token": ["C2940786#ent", "<e1>", "THR", ")", "is", "a", "rare", "C0039082#ent", "<e2>", "of", "reduced", "end", "organ", "sensitivity", "."], "h": {"id": "C2940786", "name": "C2940786#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [7, 8]}}
{"token": ["C0082874#ent", "<e1>", "HP1", ")", "and", "HP1-ORC-associated", "protein", "HOAP", ")", "are", "major", "C1136365#ent", "<e2>", "the", "telomere", "cap", "Drosophila", "and", "are", "required", "for", "telomere", "stability", "."], "h": {"id": "C0082874", "name": "C0082874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [11, 12]}}
{"token": ["It", "was", "also", "proposed", "that", "C0031381#ent", "<e1>", "may", "induce", "C1706383#ent", "<e2>", "via", "the", "sigma", "receptor"], "h": {"id": "C0031381", "name": "C0031381#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [9, 10]}}
{"token": ["In", "eukaryotes", ",", "many", "secreted", "C0086376#ent", "<e1>", "and", "peptide", "hormones", "excised", "from", "larger", "precursors", "by", "C0380871#ent", "<e2>", "the", "proprotein/prohormone", "convertases", "PCs", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0380871", "name": "C0380871#ent", "pos": [15, 16]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "investigate", "the", "role", "of", "C0907532#ent", "<e1>", "eNOS", ")", "in", "the", "anti-apoptotic", "effects", "of", "C1414438#ent", "<e2>", "in", "cardiomyocytes", "."], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [21, 22]}}
{"token": ["C0037533#ent", "<e1>", "a", "NO", "donor", ",", "increased", "baseline", "C1428360#ent", "<e2>", ",", "but", "did", "not", "reverse", "the", "effects", "of", "L-NNA", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "C0037533#ent", "<e1>", "SNP", ")", ",", "a", "potent", "hypotensive", "agent", "on", "cerebral", "blood", "flow", "C1428360#ent", "<e2>", ")", "have", "been", "extensively", "studied", "in", "clinical", "and", "experimental", "situations", "the", "results", "remain", "controversial", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [16, 17]}}
{"token": ["Of", "47", "consecutive", "patients", "with", "C0149911#ent", "<e1>", "and", "malignancy", ",", "serum", "parathyroid", "hormone", "C1705340#ent", "<e2>", ")", "was", "elevated", "in", "seven", ",", "consistent", "with", "hyperparathyroidism", "."], "h": {"id": "C0149911", "name": "C0149911#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [13, 14]}}
{"token": ["The", "study", "of", "related", "C0027203#ent", "<e1>", "activities", "reveals", "that", "tyrosine", "hydroxylase", "a", "2-day", "delay", "in", "C1415495#ent", "<e2>", "when", "compared", "to", "the", "control", "value", "19", "days", "of", "fetal", "life"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415495", "name": "C1415495#ent", "pos": [15, 16]}}
{"token": ["The", "C0079068#ent", "<e1>", "oncogene", "is", "the", "most", "extensively", "studied", "member", "of", "the", "C0026902#ent", "<e2>", "now", "consists", "of", "three", "characterized", "members", ",", "namely", "the", "C0079068#ent", "<e1>", ",", "N-myc", "and", "L-myc", "genes"], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026902", "name": "C0026902#ent", "pos": [12, 13]}}
{"token": ["It", "could", "be", "shown", "that", "recombinant", "Ara", "h", "2", "thus", "C3889446#ent", "<e1>", "and", "purified", ",", "and", "the", "C3463871#ent", "<e2>", "isolated", "from", "peanuts", "are", "identical", "as", "judged", "from", "immunoblotting", ",", "analytical", "HPLC", ",", "and", "circular", "dichroism", "spectra"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3463871", "name": "C3463871#ent", "pos": [17, 18]}}
{"token": ["Insulin", "autoimmune", "syndrome", "the", "third", "leading", "cause", "of", "C0271711#ent", "<e1>", "Japan", ",", "where", "it", "has", "been", "associated", "with", "variety", "of", "C0012634#ent", "<e2>", "and", "drugs", "."], "h": {"id": "C0271711", "name": "C0271711#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [20, 21]}}
{"token": ["The", "question", "of", "whether", "or", "not", "toluene", "diisocyanate", "airway", "C0085129#ent", "<e1>", "in", "the", "guinea-pig", "is", "accompanied", "by", "neutrophil", "influx", "bronchoalveolar", "lavage", "fluid", "C1704942#ent", "<e2>", ")", "was", "addressed", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [22, 23]}}
{"token": ["There", "was", "a", "significant", "correlation", "between", "C0085129#ent", "<e1>", "eosinophil", "counts", "in", "the", "C1704942#ent", "<e2>", "in", "the", "single", "allergen-exposed", "group", "(", "Rs", "=", "0.68", ";", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [12, 13]}}
{"token": ["C0085129#ent", "<e1>", "inhaled", "acetylcholine", "ACh", ")", "and", "inflammatory", "cell", "in", "bronchoalveolar", "lavage", "fluid", "C1704942#ent", "<e2>", ")", "were", "studied", "in", "inbred", "Brown-Norway", "rats", "actively", "sensitized", "to", ",", "and", "later", "exposed", "to", "ovalbumin", "(", "OA", ")", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "levocabastine", "on", "allergic", "and", "histamine", "(Hi)-induced", "C0009763#ent", "<e1>", "in", "guinea", "pigs", "compared", "with", "those", "of", "C0012694#ent", "<e2>", "amlexanox", "."], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [18, 19]}}
{"token": ["In", "normal", "epithelia", "C0243192#ent", "<e1>", "amiloride", "stimulated", "C3811061#ent", "<e2>", "and", "fluid", "secretion"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811061", "name": "C3811061#ent", "pos": [7, 8]}}
{"token": ["Longterm", "experience", "of", "the", "therapeutic", "security", "new", "C0038766#ent", "<e1>", "derivates", "like", "C0061323#ent", "<e2>", "is", "lacking", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [7, 8]}, "relation": "structural_class_of", "t": {"id": "C0061323", "name": "C0061323#ent", "pos": [11, 12]}}
{"token": ["C0038766#ent", "<e1>", "(", "glibenclamide", "and", "C0061323#ent", "<e2>", ",", "but", "not", "gliclazide", ")", "and", "nateglinide", "stimulated", "ROS", "production", "via", "protein", "kinase", "activation", "of", "NAD(P)H", "oxidase", "consequently", "caused", "beta-cell", "apoptosis", "in", "vitro"], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0061323", "name": "C0061323#ent", "pos": [5, 6]}}
{"token": ["A", "C0011524#ent", "<e1>", "restriction", ")", "endonuclease", "(", "R.CviAII", ")", "and", "its", "C0012873#ent", "<e2>", "M.CviAII", ")", "were", "isolated", "from", "virus", "PBCV-1", "infected", "Chlorella", "strain", "NC64A", "cells", "."], "h": {"id": "C0011524", "name": "C0011524#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012873", "name": "C0012873#ent", "pos": [11, 12]}}
{"token": ["The", "Hp", "polymorphism", "is", "related", "to", "the", "prevalence", "and", "the", "outcome", "of", "various", "pathological", "conditions", "with", "altered", "iron", "metabolism", "as", "C1384665#ent", "<e1>", ",", "infections", ",", "and", "C0004153#ent", "<e2>"], "h": {"id": "C1384665", "name": "C1384665#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [26, 27]}}
{"token": ["In", "conclusion", ",", "neither", "ferritin", "nor", "a", "C1384665#ent", "<e1>", "genotype", "was", "related", "to", "brachial", "endothelial", "function", "or", "C0004153#ent", "<e2>"], "h": {"id": "C1384665", "name": "C1384665#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [17, 18]}}
{"token": ["The", "results", "indicate", "that", "the", "metabolism", "of", "C1955936#ent", "<e1>", "from", "that", "of", "group", "II", "phospholipase", "A2", "C0022661#ent", "<e2>"], "h": {"id": "C1955936", "name": "C1955936#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [16, 17]}}
{"token": ["The", "significance", "of", "the", "close", "linkage", "of", "genes", "determining", "Meth", "A", "antigen", "expression", "with", "the", "C0017351#ent", "<e1>", "on", "chromosome", "12", "and", "the", "C0314619#ent", "<e2>", "on", "chromosome", "16", "is", "discussed", "."], "h": {"id": "C0017351", "name": "C0017351#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0314619", "name": "C0314619#ent", "pos": [22, 23]}}
{"token": ["The", "effect", "of", "VSMp", "on", "C4283800#ent", "<e1>", "could", "be", "blocked", "by", "C0001640#ent", "<e2>", "yohimbine", ",", "but", "not", "by", "alpha", "1-adrenoceptor", "antagonist", "prazosine", "when", "VSMp", "was", "stimulated", "."], "h": {"id": "C4283800", "name": "C4283800#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [11, 12]}}
{"token": ["We", "found", "that", "serum", "HGF", "levels", "were", "significantly", "higher", "in", "patients", "with", "C0005943#ent", "<e1>", "p", "<", "0.0001", ")", "compared", "to", "patients", "with", "C0524909#ent", "<e2>", "healthy", "controls"], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [22, 23]}}
{"token": ["In", "heterozygote", "beta-thalassemic", "subjects", "a", "higher", "incidence", "of", "C0005943#ent", "<e1>", "of", "liver", "diseases", "progression", "toward", "C0524909#ent", "<e2>", "been", "assessed", "."], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [15, 16]}}
{"token": ["COL-3", "treatment", "prevented", "septic", "shock", "C0243025#ent", "<e1>", "and", "significantly", "decreased", "cytokine", "levels", "in", "plasma", "and", "C1704942#ent", "<e2>", "."], "h": {"id": "C0243025", "name": "C0243025#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [15, 16]}}
{"token": ["Gene", "polymorphism", "C3536785#ent", "<e1>", "IL-1ra", ")", "and", "TNF-alpha", "were", "determined", "in", "297", "C2316810#ent", "<e2>", "patients", "and", "in", "145", "normal", "healthy", "controls"], "h": {"id": "C3536785", "name": "C3536785#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [12, 13]}}
{"token": ["It", "has", "been", "recently", "demonstrated", "by", "many", "authors", "that", "diastolic", "abnormalities", "the", "left", "ventricle", "the", "earliest", "C0029166#ent", "<e1>", "myocardial", "ischemia", "both", "the", "ECG", "changes", "and", "C0002962#ent", "<e2>"], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [25, 26]}}
{"token": ["Both", "patients", "exhibited", "C0029166#ent", "<e1>", "such", "as", "general", "rash", "urticaria", ",", "along", "with", "C0002962#ent", "<e2>", "electrocardiographic", "ST-segment", "elevations", "after", "suppository", "administration", "of", "diclofenac", "sodium", "indomethacin", ",", "the", "most", "commonly", "used", "NSAIDs", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [13, 14]}}
{"token": ["As", "expected", ",", "subjects", "with", "SRQ", "and", "ARE", "haplotypes", "are", "relatively", "hypercalcemic", ",", "and", "those", "with", "AGQ", "are", "C0039613#ent", "<e1>", ",", "relative", "to", "subjects", "with", "the", "common", "C4287680#ent", "<e2>", "haplotype", "."], "h": {"id": "C0039613", "name": "C0039613#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4287680", "name": "C4287680#ent", "pos": [27, 28]}}
{"token": ["The", "C0162298#ent", "<e1>", "of", "the", "C1414073#ent", "<e2>", "graft-fixation", "complex", "was", "lowered", "fourfold", "to", "40-fold", "by", "adding", "fixation", "."], "h": {"id": "C0162298", "name": "C0162298#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414073", "name": "C1414073#ent", "pos": [5, 6]}}
{"token": ["We", "propose", "that", "the", "C0020615#ent", "<e1>", "effect", "of", "SN", "occurs", "without", "C2712370#ent", "<e2>", "the", "insulin", "concentration", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [11, 12]}}
{"token": ["Abnormalities", "of", "IL-15", "expression", "have", "been", "described", "in", "patients", "with", "C0003873#ent", "<e1>", "inflammatory", "bowel", "disease", "in", "diseases", "associated", "with", "C0079556#ent", "<e2>", "human", "T-cell", "lymphotropic", "virus", "I", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079556", "name": "C0079556#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "suggest", "that", "sIL-2R", "is", "a", "useful", "marker", "for", "disease", "activity", "collagen", "diseases", "especially", "in", "C0003873#ent", "<e1>", ",", "and", "chronic", "viral", "infection", "as", "HBV", ",", "HCV", "or", "C0079556#ent", "<e2>", "in", "HD", "patients", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0079556", "name": "C0079556#ent", "pos": [28, 29]}}
{"token": ["Paroxysmal", "nocturnal", "haemoglobinuria", "C1420232#ent", "<e1>", ")", "is", "a", "clonal", "disorder", "haematopoietic", "stem", "cells", "by", "somatic", "C1418558#ent", "<e2>", "mutations", ",", "resulting", "in", "a", "deficiency", "in", "glycosylphosphatidylinositol-anchored", "proteins", "GPI-AP", ")", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418558", "name": "C1418558#ent", "pos": [15, 16]}}
{"token": ["IGR-NB8", "is", "an", "immature", "NB", "xenograft", "with", "C1705027#ent", "<e1>", "amplification", "and", "1p", "deletion", "which", "is", "sensitive", "to", "C0594375#ent", "<e2>", "."], "h": {"id": "C1705027", "name": "C1705027#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "CD72", "and", "BCR", "activated", "the", "extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e1>", ")", "and", "the", "C0380051#ent", "<e2>", "JNK", ")", "but", "not", "p38", "mitogen-activated", "protein", "kinase"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [15, 16]}}
{"token": ["Interestingly", ",", "the", "C1370600#ent", "<e1>", "(", "extracellular-signal-regulated", "kinase", "and", "JNK", "(", "c-Jun", "N-terminal", "kinase)/SAPK", "C0380051#ent", "<e2>", "signalling", "pathways", "neither", "necessary", "nor", "sufficient", "to", "induce", "ATF3", "in", "the", "anisomycin", "stress", "paradigm", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [14, 15]}}
{"token": ["We", "previously", "reported", "the", "protective", "effects", "PBN", "against", "ischemia-reperfusion", "injury", "gerbil", "hippocampus", "by", "its", "activation", "of", "extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e1>", ")", "and", "suppression", "of", "both", "C0380051#ent", "<e2>", "p38", "mitogen-activated", "protein", "kinase"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [19, 20]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [26, 27]}}
{"token": ["C1705021#ent", "<e1>", "is", "thought", "to", "contribute", "to", "C3273872#ent", "<e2>", "susceptibility", "but", "this", "view", "has", "been", "difficult", "to", "reconcile", "with", "the", "lack", "of", "linkage", "evidence"], "h": {"id": "C1705021", "name": "C1705021#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [7, 8]}}
{"token": ["Since", "DNA", "cleavage", "in", "accordance", "with", "the", "scheme", ":", "[", "formula", ":", "see", "text", "]", "the", "C0027203#ent", "<e1>", "can", "be", "assigned", "to", "the", "C0012906#ent", "<e2>", "represents", "an", "isoschizomer", "of", "HindIII", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "the", "C0027203#ent", "<e1>", "is", "a", "true", "isoschizomer", "for", "C0012906#ent", "<e2>", "and", "ClaI."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "C0074722#ent", "<e1>", "and", "ACEIs", "on", "C0149931#ent", "<e2>", "is", "probably", "not", "attributable", "to", "their", "effect", "on", "blood", "pressure"], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [8, 9]}}
{"token": ["Some", "of", "these", "ICSBP", "effects", "may", "be", "explained", "in", "part", "by", "an", "ICSBP-mediated", "repression", "of", "C0376515#ent", "<e1>", ",", "a", "major", "antiapoptotic", "target", "of", "C1835417#ent", "<e2>", ",", "on", "transcriptional", "and", "protein", "level"], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1835417", "name": "C1835417#ent", "pos": [23, 24]}}
{"token": ["The", "avian-virus-derived", "protein", "'", "Apoptin", "'", ",", "induces", "apoptosis", "in", "a", "p53-independent", "way", ",", "is", "stimulated", "by", "C0376515#ent", "<e1>", "and", "is", "insensitive", "to", "C1835417#ent", "<e2>", ",", "another", "inhibitor", "of", "chemotherapeutic", "agents"], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1835417", "name": "C1835417#ent", "pos": [23, 24]}}
{"token": ["The", "production", "of", "interferons", "(", "C1415900#ent", "<e1>", ")", "by", "peripheral", "blood", "leucocytes", "normal", "donors", "patients", "with", "systemic", "lupus", "erythematosus", "SLE", ")", "and", "C0038013#ent", "<e2>", "RA", ")", "has", "been", "investigated", "in", "response", "to", "several", "C1415900#ent", "<e1>", "inducers", "in", "vitro"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [5, 6]}}
{"token": ["PBMC", "from", "C0038013#ent", "<e1>", "RA", ")", "patients", "released", "moderately", "elevated", "levels", "of", "C1415900#ent", "<e2>", "(", "236", "+", "/-", "62", "U/ml", "vs", "168", "+", "/-", "34", "in", "normals", ")", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [12, 13]}}
{"token": ["The", "cases", "with", "SLE", ",", "thrombocytopenic", "purpura", "C0038013#ent", "<e1>", "psoriasis", "showed", "good", "prognosis", "after", "cessation", "of", "C1415900#ent", "<e2>", "administration", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [16, 17]}}
{"token": ["The", "gene", "for", "C1419712#ent", "<e1>", "rps16", ")", "is", "encoded", "in", "the", "C1955992#ent", "<e2>", "most", "higher", "plants", "but", "not", "in", "Medicago", "truncatula", "Populus", "alba"], "h": {"id": "C1419712", "name": "C1419712#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1955992", "name": "C1955992#ent", "pos": [11, 12]}}
{"token": ["Four", "genes", ",", "rps15", ",", "C1419712#ent", "<e1>", ",", "rpl32", "and", "ycf10", ",", "found", "in", "most", "C1955992#ent", "<e2>", "land", "plants", "not", "present", "in", "S.", "uncinata", "."], "h": {"id": "C1419712", "name": "C1419712#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1955992", "name": "C1955992#ent", "pos": [15, 16]}}
{"token": ["C0022265#ent", "<e1>", "is", "only", "partially", "effective", "in", "C1419789#ent", "<e2>", ",", "in", "contrast", "to", "etretinate", "which", "is", "very", "effective", "in", "C1419789#ent", "<e2>", "but", "ineffective", "in", "severe", "acne", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [7, 8]}}
{"token": ["The", "data", "collected", "in", "this", "study", "were", "briefly", "discussed", "with", "regard", "to", "the", "use", "of", "C0022265#ent", "<e1>", "its", "derivatives", "in", "C1419789#ent", "<e2>", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [20, 21]}}
{"token": ["The", "reduced", "C0085129#ent", "<e1>", "response", "was", "accompanied", "by", "a", "significant", "reduction", "in", "C0014457#ent", "<e2>", "accumulation", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [12, 13]}}
{"token": ["These", "resultssuggest", "that", ",", "in", "allergen-induced", "asthma", "TSLP", "acts", "on", "NKT", "cells", "enhance", "airway", "C0085129#ent", "<e1>", "by", "upregulating", "their", "IL-13", "production", ",", "whereas", "C0014457#ent", "<e2>", "and", "IgE", "production", "are", "not", "influenced", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [23, 24]}}
{"token": ["The", "examination", "of", "the", "nasal", "cavity", "hour", "after", "the", "single", "dose", "100", "micrograms/kg", "body", "weight", "C0009014#ent", "<e1>", "in", "rats", "showed", "no", "sign", "C0041834#ent", "<e2>", ",", "oedema", "or", "lesions", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [22, 23]}}
{"token": ["The", "comparative", "analysis", "demonstrated", "high", "degree", "of", "conservation", "of", "the", "C3811248#ent", "<e1>", "fragments", "in", "Tu80", "and", "C1824308#ent", "<e2>", ",", "as", "well", "as", "in", "the", "C3811248#ent", "<e1>", "in", "a", "number", "of", "mammalian", "species", "."], "h": {"id": "C1824308", "name": "C1824308#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3811248", "name": "C3811248#ent", "pos": [10, 11]}}
{"token": ["The", "C1335494#ent", "<e1>", "both", "these", "plasmid", "types", "can", "substitute", "for", "the", "C0969663#ent", "<e2>", "chromosomal", "DNA", "replication"], "h": {"id": "C1335494", "name": "C1335494#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0969663", "name": "C0969663#ent", "pos": [11, 12]}}
{"token": ["This", "clinical", "laboratory", "study", "how", "the", "timing", "of", "drinking", "and", "subjective", "responses", "C0001975#ent", "<e1>", "are", "effected", "by", "the", "C3536879#ent", "<e2>", "naltrexone", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3536879", "name": "C3536879#ent", "pos": [18, 19]}}
{"token": ["Additional", "groups", "of", "animals", "were", "injected", "with", "either", "indomethacin", "(", "an", "inhibitor", "of", "C0040060#ent", "<e1>", "or", "Ketanserin", "(", "a", "C0036753#ent", "<e2>", "before", "light", "treatment"], "h": {"id": "C0040060", "name": "C0040060#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0036753", "name": "C0036753#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "IFN-gamma", "upregulated", "C1332791#ent", "<e1>", "or", "IL-5-induced", "phosphorylation", "of", "extracellular", "signal-regulated", "kinase", "C3849574#ent", "<e2>", ")", ",", "p38", "mitogen-activated", "protein", "kinase", "MAPK", ")", ",", "c-Jun", "N-terminal", "kinase", "JNK", ")", ",", "and", "activating", "transcription", "factor", "(ATF)-2"], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [13, 14]}}
{"token": ["Pseudotumor", "cerebri", "a", "C0039082#ent", "<e1>", "characterized", "by", "C0033845#ent", "<e2>", "intracranial", "pressure", "200", "mmH2O", ")", "and", "a", "normal", "ventricular", "system"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033845", "name": "C0033845#ent", "pos": [7, 8]}}
{"token": ["When", "no", "secondary", "cause", "is", "identified", ",", "the", "C0039082#ent", "<e1>", "is", "termed", "\"", "C0033845#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033845", "name": "C0033845#ent", "pos": [13, 14]}}
{"token": ["A", "17-year-old", "female", "developed", "a", "C0039082#ent", "<e1>", "of", "benign", "C0033845#ent", "<e2>", "a", "minor", "craniocerebral", "trauma"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033845", "name": "C0033845#ent", "pos": [9, 10]}}
{"token": ["Pseudotumor", "cerebri", "PTC", ")", "is", "a", "C0039082#ent", "<e1>", "characterized", "by", "C0033845#ent", "<e2>", "associated", "with", "headaches", ",", "visual", "disturbances", "papilledema", ",", "but", "without", "any", "identifiable", "intracranial", "pathology"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033845", "name": "C0033845#ent", "pos": [10, 11]}}
{"token": ["FANCD2", "colocalized", "with", "C1419240#ent", "<e1>", "in", "foci", "following", "treatment", "with", "C0026254#ent", "<e2>", "hydroxyurea", ",", "and", "colocalized", "very", "tightly", "with", "PCNA", "after", "treatment", "with", "hydroxyurea", "."], "h": {"id": "C1419240", "name": "C1419240#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [10, 11]}}
{"token": ["injection", "of", "the", "non-NMDA", "antagonists", "DNQX", "and", "C0045376#ent", "<e1>", ",", "but", "not", "by", "the", "muscarinic", "antagonists", "scopolamine", "or", "C1161352#ent", "<e2>", ",", "or", "the", "metabotropic", "antagonist", "AP3", "."], "h": {"id": "C0045376", "name": "C0045376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [18, 19]}}
{"token": ["In", "study", "3", ",", "C0521840#ent", "<e1>", "found", "in", "52.5", "%", ",", "C1453952#ent", "<e2>", "in", "35.6", "%", "and", "necrotizing", "gingivo-periodontitis", "27.7", "%", "."], "h": {"id": "C0521840", "name": "C0521840#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1453952", "name": "C1453952#ent", "pos": [11, 12]}}
{"token": ["The", "C0010760#ent", "<e1>", "Escherichia", "coli", "one", "of", "two", "C0068800#ent", "<e2>", "the", "bacterium", "synthesizes", "."], "h": {"id": "C0010760", "name": "C0010760#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0068800", "name": "C0068800#ent", "pos": [8, 9]}}
{"token": ["Immunoblotting", "experiments", "revealed", "that", "the", "immunoprecipitates", "of", "C1333225#ent", "<e1>", "contain", "p56lck", ",", "a", "member", "of", "the", "C0038085#ent", "<e2>", "tyrosine", "kinases"], "h": {"id": "C1333225", "name": "C1333225#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "C0031007#ent", "<e1>", ",", "a", "potent", "dopamine", "C2987634#ent", "<e2>", ",", "on", "exercise-induced", "plasma", "prolactin", "PRL", ")", "changes", "were", "studied", "in", "normal", "men", "."], "h": {"id": "C0031007", "name": "C0031007#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [9, 10]}}
{"token": ["Patients", "with", "C0030759#ent", "<e1>", "with", "scalp", "pruritus", "excoriations", ",", "cervical", "lymphadenopathy", "and", "C0009763#ent", "<e2>", "."], "h": {"id": "C0030759", "name": "C0030759#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [12, 13]}}
{"token": ["Currently", "C1868677#ent", "<e1>", "control", "is", "done", "by", "vaccination", "with", "an", "attenuated", "C1868677#ent", "<e1>", "strain", "(", "Nigeria", "75/1", ")", "produced", "in", "C0872351#ent", "<e1>", "of", "Vero", "cells", "in", "roller", "bottles", "static", "flasks"], "h": {"id": "C1868677", "name": "C1868677#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [20, 21]}}
{"token": ["This", "latency", "difference", "that", "2-month-old", "infants", "at", "risk", "for", "C1428905#ent", "<e1>", "are", "already", "affected", "in", "processing", "an", "auditory", "stimulus", "of", "C0720099#ent", "<e2>", "."], "h": {"id": "C1428905", "name": "C1428905#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [20, 21]}}
{"token": ["The", "C1428905#ent", "<e1>", "levels", "and", "AchE", "activities", "were", "not", "correlated", "with", "the", "C0720099#ent", "<e2>", "and", "the", "dementia", "score", "."], "h": {"id": "C1428905", "name": "C1428905#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [12, 13]}}
{"token": ["The", "complications", "of", "C0034186#ent", "<e1>", "are", "also", "more", "common", "in", "patients", "with", "C0011847#ent", "<e2>", "."], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [12, 13]}}
{"token": ["Although", "C1416902#ent", "<e1>", "activation", "was", "impaired", "in", "C0041948#ent", "<e2>", "subjects", "and", "renal", "transplant", "recipients", ",", "this", "appeared", "to", "be", "due", "more", "to", "the", "presence", "of", "an", "inhibitor", "than", "to", "cofactor", "deficiency"], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "C1706373#ent", "<e1>", "purified", "from", "cardiac", "SR", "phosphorylated", "by", "exogenous", "C1871221#ent", "<e2>", "the", "phosphorylated", "enzyme", "displays", "2-fold", "increase", "in", "catalytic", "activity", "any", "appreciable", "change", "in", "its", "Ca2", "+", "sensitivity", "."], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1871221", "name": "C1871221#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "here", "a", "novel", "mechanism", "for", "the", "regulation", "of", "the", "C1706373#ent", "<e1>", "through", "direct", "phosphorylation", "of", "this", "enzyme", "by", "a", "Ca2+/calmodulin-dependent", "protein", "kinase", "C1871221#ent", "<e2>", "associated", "with", "SR", "membrane", "."], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1871221", "name": "C1871221#ent", "pos": [24, 25]}}
{"token": ["C1743497#ent", "<e1>", ",", "the", "product", "of", "superoxide", "dismutase", "2", "C1420307#ent", "<e2>", ")", "gene", ",", "is", "one", "of", "the", "major", "cellular", "defences", "oxidative", "stress"], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420307", "name": "C1420307#ent", "pos": [9, 10]}}
{"token": ["An", "increase", "in", "the", "activity", "of", "C1417932#ent", "<e1>", "also", "observed", "in", "C0023281#ent", "<e2>", "spleen", "from", "BALB/C", "mice"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023281", "name": "C0023281#ent", "pos": [11, 12]}}
{"token": ["C0771029#ent", "<e1>", "is", "also", "effective", "against", "C0040262#ent", "<e2>", "vaginal", "candidosis", "but", "only", "topically", "."], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040262", "name": "C0040262#ent", "pos": [6, 7]}}
{"token": ["Retroviral", "vectors", "used", "to", "express", "c-myc", "and", "dominant", "negative", "mutant", "c-myc", "C1417679#ent", "<e1>", "in", "rat", "1", "cells", ",", "with", "and", "without", "ca-transfection", "of", "C0080279#ent", "<e2>", "as", "measured", "by", "clonogenic", "assay", "rat", "1", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [23, 24]}}
{"token": ["The", "Philadelphia", "chromosome", "translocation", "t(9;22", ")", ")", "results", "in", "the", "molecular", "juxtaposition", "of", "two", "C1417679#ent", "<e1>", ",", "BCR", "and", "C0080279#ent", "<e2>", ",", "to", "form", "an", "aberrant", "BCR-ABL", "gene", "on", "chromosome", "22"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [19, 20]}}
{"token": ["Two", "C1417679#ent", "<e1>", "overexpressed", "in", "myeloma", "cells", "C0080279#ent", "<e2>", "and", "cystathionine", "beta", "synthase)", "code", "enzymes", "that", "could", "be", "a", "therapeutic", "target", "with", "specific", "drugs", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [7, 8]}}
{"token": ["Upon", "keratinocytes", "differentiation", ",", "NF-Y", "and", "p63", "remain", "bound", "to", "G(2)/M", "promoters", ",", "while", "C1422386#ent", "<e1>", "are", "recruited", ",", "histones", "deacetylated", ",", "C0012889#ent", "<e2>", "and", "transcription", "repressed", "."], "h": {"id": "C1422386", "name": "C1422386#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012889", "name": "C0012889#ent", "pos": [22, 23]}}
{"token": ["Endocrine", "disturbances", "associated", "with", "C3250443#ent", "<e1>", "MD", ")", "include", "C0156312#ent", "<e2>", "hyperinsulinemic", "glucose", "intolerance", "thyroid", "abnormalities", "and", "low", "or", "low", "normal", "urinary", "17-ketosteroid", "(", "17-KS", ")", "excretion", "."], "h": {"id": "C3250443", "name": "C3250443#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0156312", "name": "C0156312#ent", "pos": [9, 10]}}
{"token": ["Progression", "from", "insulitis", "to", "C0205734#ent", "<e1>", "occurred", "in", "these", "recipients", "when", "C1423842#ent", "<e2>", "but", "not", "Th2", "TCR7", "cells", "were", "transferred", "and", "CTLA-4", "signaling", "was", "simultaneously", "blocked", "."], "h": {"id": "C0205734", "name": "C0205734#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [11, 12]}}
{"token": ["Because", "C1423842#ent", "<e1>", "cytokines", "have", "been", "associated", "with", "pathogenesis", "of", "C0205734#ent", "<e2>", "these", "results", "preclude", "C1423842#ent", "<e1>", "involvement", "in", "the", "autoimmune", "phenomena", "in", "LADA", "patients", "."], "h": {"id": "C0205734", "name": "C0205734#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [1, 2]}}
{"token": ["Hybridization", "was", "not", "detected", "with", "the", "C1336966#ent", "<e1>", "v-ras", ",", "which", "indicated", "this", "C0029016#ent", "<e2>", "was", "absent", "in", "the", "equine", "genome", "."], "h": {"id": "C1336966", "name": "C1336966#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [13, 14]}}
{"token": ["This", "cluster", "contains", "13", "genes", "encoding", "C3273837#ent", "<e1>", "calcium-binding", "proteins", "some", "of", "which", "(", "C1419789#ent", "<e2>", ",", "S100A8", "and", "S100A9", ")", "are", "known", "to", "be", "up-regulated", "in", "individual", "patient", "keratinocytes", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [14, 15]}}
{"token": ["Treatment", "involving", "the", "use", "of", "C0032911#ent", "<e1>", "and", "albendazole", "were", "ineffective", ",", "but", "C0015821#ent", "<e2>", "successfully", "cleared", "Mesocestoides", "infections", "5", "of", "6", "dogs", "."], "h": {"id": "C0032911", "name": "C0032911#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015821", "name": "C0015821#ent", "pos": [13, 14]}}
{"token": ["The", "sample", "component", "chloride", "as", "a", "leading", "C3536863#ent", "<e1>", "induced", "stacking", "by", "an", "isotachophoretic", "mechanism", "and", "the", "complexing", "agent", "4-(2-pyridylazo", ")", "resorcinol", "(", "C1417826#ent", "<e2>", ")", "acted", "as", "a", "terminating", "C3536863#ent", "<e1>", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [7, 8]}}
{"token": ["The", "salt", "anion", "chloride", ")", "and", "C1417826#ent", "<e1>", "in", "the", "sample", "matrix", "as", "the", "leading", "and", "terminating", "C3536863#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [17, 18]}}
{"token": ["The", "nosological", "relationship", "Bickerstaff", "s", "C0014038#ent", "<e1>", "BBE", ")", "and", "C3825808#ent", "<e2>", "GBS", ")", "has", "yet", "to", "be", "clarified", "."], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3825808", "name": "C3825808#ent", "pos": [10, 11]}}
{"token": ["PTIO", "directly", "extinguishes", "NO", "generated", "by", "C0132555#ent", "<e1>", "C0669372#ent", "<e2>", ")", "without", "affecting", "C0669372#ent", "<e2>", "activity", ",", "which", "is", "a", "clear", "contrast", "to", "C0669372#ent", "<e2>", "inhibitors", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}}
{"token": ["Using", "data", "obtained", "from", "the", "research", "group", "we", "analyzed", "the", "efficacy", "and", "safety", "of", "C0939219#ent", "<e1>", ",", "as", "compared", "with", "mefloquine", ",", "in", "C0455988#ent", "<e2>", "patients", "with", "uncomplicated", "P.", "falciparum", "malaria", "."], "h": {"id": "C0939219", "name": "C0939219#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [23, 24]}}
{"token": ["This", "study", "attempts", "to", "identify", "the", "relative", "contribution", "of", "coping", "styles", "task-", ",", "emotion-oriented", "and", "avoidance", ")", "and", "anxiety", "and", "C0342257#ent", "<e1>", "glycemic", "control", "in", "IDDM", "(", "C0011854#ent", "<e2>", "patients", "."], "h": {"id": "C0342257", "name": "C0342257#ent", "pos": [20, 21]}, "relation": "related_to", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [27, 28]}}
{"token": ["Herpes", "zoster", "reactivaction", "in", "the", "head", "and", "neck", "region", "often", "associated", "with", "C0010266#ent", "<e1>", "the", "most", "common", "one", "being", "C0376175#ent", "<e2>"], "h": {"id": "C0010266", "name": "C0010266#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0376175", "name": "C0376175#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "C0074460#ent", "<e1>", "may", "have", "an", "inhibitory", "action", "on", "the", "C0389003#ent", "<e2>", "in", "both", "platelets", "and", "aorta", "."], "h": {"id": "C0074460", "name": "C0074460#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0389003", "name": "C0389003#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesized", "that", "the", "activated", "kinase", "of", "C0072479#ent", "<e1>", ",", "in", "the", "form", "of", "C1417031#ent", "<e2>", ",", "when", "expressed", "in", "patients", "with", "thyroid", "disease", "presents", "an", "unusual", "altered", "self", "target", "for", "T", "cell", "recognition"], "h": {"id": "C0072479", "name": "C0072479#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417031", "name": "C1417031#ent", "pos": [14, 15]}}
{"token": ["Sequence", "comparisons", "no", "similarity", "to", "phosphorylating", "C0017857#ent", "<e1>", "revealed", "a", "relationship", "to", "C0684287#ent", "<e2>", "with", "the", "highest", "similarity", "to", "the", "subgroup", "of", "nonphosphorylating", "glyceraldehyde-3-phosphate", "dehydrogenases"], "h": {"id": "C0017857", "name": "C0017857#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0684287", "name": "C0684287#ent", "pos": [12, 13]}}
{"token": ["We", "tested", "this", "hypothesis", "in", "a", "recently", "developed", "mouse", "model", "anti-MPO", "IgG-induced", "C0156221#ent", "<e1>", "by", "using", "bacterial", "lipopolysaccharide", "C2697656#ent", "<e2>", ")", "as", "the", "proinflammatory", "stimulus", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [18, 19]}}
{"token": ["The", "objective", "of", "the", "present", "work", "was", "to", "characterize", "some", "aspects", "of", "interleukin-1", "(", "IL-1", ")", "production", "by", "C0156221#ent", "<e1>", "stimulation", "with", "bacterial", "lipopolysaccharide", "C2697656#ent", "<e2>", ")", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [24, 25]}}
{"token": ["C3273394#ent", "<e1>", "was", "also", "highly", "homologous", "to", "another", "C0017337#ent", "<e2>", "(", "BCL11B", ")", "on", "chromosome", "14q32.1"], "h": {"id": "C3273394", "name": "C3273394#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["TNFalpha", "also", "enhanced", "C1706544#ent", "<e1>", "expression", "on", "C0968917#ent", "<e2>", "through", "nuclear", "factor-kappaB", "activation"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0968917", "name": "C0968917#ent", "pos": [7, 8]}}
{"token": ["We", "aimed", "to", "evaluate", "whether", "serum", "factors", "in", "PE", "influence", "intercellular", "adhesion", "molecule-1", "C1706544#ent", "<e1>", ")", "expression", "of", "C0968917#ent", "<e2>", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0968917", "name": "C0968917#ent", "pos": [18, 19]}}
{"token": ["The", "present", "study", "has", "further", "characterized", "this", "soluble", "enzyme", "and", "compared", "its", "properties", "to", "those", "of", "the", "membrane-bound", ",", "C0089793#ent", "<e1>", "activity", "of", "the", "adrenal", "cortex", "the", "C0011525#ent", "<e2>", "bovine", "brain", "."], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0011525", "name": "C0011525#ent", "pos": [27, 28]}}
{"token": ["The", "biochemical", "properties", "of", "C0089793#ent", "<e1>", "are", "characteristic", "of", "a", "C0011525#ent", "<e2>"], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011525", "name": "C0011525#ent", "pos": [10, 11]}}
{"token": ["In", "developing", "mouse", "embryos", ",", "the", "expression", "of", "the", "cardiac", "N2-B", "C0597298#ent", "<e1>", "remains", "strictly", "C1413784#ent", "<e2>", "and", "is", "linked", "to", "the", "expression", "of", "the", "ubiquitous", "N2-A", "C0597298#ent", "<e1>", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413784", "name": "C1413784#ent", "pos": [15, 16]}}
{"token": ["A549", "cells", "a", "lowered", "capacity", "to", "reduce", "peroxide", "due", "to", "the", "effect", "of", "C0599532#ent", "<e1>", "depletion", "on", "the", "C3540017#ent", "<e2>", "GSH-peroxidase", "and", "GSH-S-transferase", ",", "which", "require", "the", "tripeptide", "as", "a", "substrate", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [18, 19]}}
{"token": ["These", "observations", "suggest", "that", "a", "C0599532#ent", "<e1>", "mediator", "is", "essential", "for", "the", "reductive", "activation", "carboxylating", "C3540017#ent", "<e2>", "of", "photosynthesis", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [15, 16]}}
{"token": ["We", "also", "found", "that", "cut", "interacts", "genetically", "with", "the", "C1334889#ent", "<e1>", "with", "the", "catalytic", "subunit", "C0033640#ent", "<e2>", "egg", "chamber", "morphogenesis", "."], "h": {"id": "C1334889", "name": "C1334889#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [15, 16]}}
{"token": ["Enforced", "oligomerization", "of", "RICK", "or", "C1826849#ent", "<e1>", "as", "well", "as", "of", "IKKgamma", ",", "IKKalpha", ",", "or", "C1442489#ent", "<e2>", "was", "sufficient", "for", "induction", "of", "NF-kappaB", "activation"], "h": {"id": "C1826849", "name": "C1826849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1442489", "name": "C1442489#ent", "pos": [16, 17]}}
{"token": ["Its", "overexpression", "inhibited", "pro-caspase-9", "activation", "leading", "to", "the", "suppression", "of", "the", "cell", "death", "induced", "by", "a", "protein", "kinase", "inhibitor", "C0075193#ent", "<e1>", ",", "or", "a", "C0003392#ent", "<e2>", "etoposide", "(", "VP-16", ")", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [24, 25]}}
{"token": ["The", "indolocarbazole", "antibiotics", "C0075193#ent", "<e1>", "and", "rebeccamycin", "(", "1", ")", "are", "potent", "C0003392#ent", "<e2>", "protein", "kinase", "C", "topoisomerase", "I", "respectively", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [12, 13]}}
{"token": ["Unlike", "previously", "described", "antiapoptotic", "proteins", "did", "not", "protect", "against", "anti-Fas", ",", "tumor", "necrosis", "factor-alpha", "C0075193#ent", "<e1>", ",", "UV-light", ",", "or", "a", "number", "of", "C0003392#ent", "<e2>"], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [23, 24]}}
{"token": ["C0075193#ent", "<e1>", ",", "a", "potential", "C0003392#ent", "<e2>", "was", "found", "recently", "to", "up-regulate", "the", "expression", "of", "the", "COX-2", "gene", "the", "mouse", "osteoblast-like", "cell", "line", "MC3T3-E1", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [5, 6]}}
{"token": ["Probably", "by", "interference", "with", "this", "feedback", "mechanism", "in", "the", "rat", ",", "C0007332#ent", "<e1>", "is", "a", "stronger", "C0002763#ent", "<e2>", "of", "plasma", "CCK", "release", "and", "pancreatic", "exocrine", "secretion", "fat", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [16, 17]}}
{"token": ["In", "human", "colon", "carcinoma", "cells", "C0661256#ent", "<e1>", "inhibits", "cell", "growth", "upregulating", "expression", "of", "the", "p21", "gene", "a", "C0080054#ent", "<e2>", "Cdk", ")", "inhibitor", "."], "h": {"id": "C0661256", "name": "C0661256#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [17, 18]}}
{"token": ["C1414313#ent", "<e1>", "EGFR", ")", "is", "a", "C0021699#ent", "<e2>", "binds", "EGF", "in", "its", "extracellular", "domain", "initiates", "signaling", "via", "intrinsic", "tyrosine", "kinase", "activity", "its", "cytoplasmic", "domain"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}}
{"token": ["However", ",", "the", "aim", "of", "our", "study", "was", "to", "determine", "if", "C0015133#ent", "<e1>", "was", "non-cross-resistant", "with", "C1171558#ent", "<e2>", "analogues", "and", "therefore", "we", "also", "developed", "additional", "response", "criteria", "on", "serial", "CA", "125", "levels", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1171558", "name": "C1171558#ent", "pos": [16, 17]}}
{"token": ["The", "cause", "is", "postulated", "to", "be", "an", "C1706005#ent", "<e1>", "autoantibody", "directed", "against", "components", "of", "the", "C1335809#ent", "<e2>"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335809", "name": "C1335809#ent", "pos": [15, 16]}}
{"token": ["In", "order", "to", "understand", "how", "this", "specificity", "is", "achieved", ",", "we", "searched", "for", "C1422337#ent", "<e1>", "mutations", "able", "to", "compensate", "for", "the", "lack", "of", "C1333212#ent", "<e2>", "functions", "."], "h": {"id": "C1422337", "name": "C1422337#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333212", "name": "C1333212#ent", "pos": [23, 24]}}
{"token": ["3", "Exposure", "to", "C0041912#ent", "<e1>", "which", "results", "in", "depletion", "of", "C0356622#ent", "<e2>", "reduces", "the", "effect", "of", "THC", "."], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [10, 11]}}
{"token": ["C1421293#ent", "<e1>", "is", "the", "prototype", "for", "the", "HECT", "domain", "family", "of", "C1418270#ent", "<e2>"], "h": {"id": "C1421293", "name": "C1421293#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [11, 12]}}
{"token": ["C1421293#ent", "<e1>", "is", "an", "C1418270#ent", "<e2>", "together", "with", "16E6", "interacts", "with", "p53", "to", "target", "p53", "degradation", "."], "h": {"id": "C1421293", "name": "C1421293#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [4, 5]}}
{"token": ["In", "sequential", "exposure", "to", "of", "these", "three", "chemicals", "after", "DEN", ",", "liver", "tumor", "production", "was", "markedly", "enhanced", "by", "PCB", ",", "and", "moderately", "by", "C0282303#ent", "<e1>", "but", "minimal", "by", "C1413950#ent", "<e2>", "."], "h": {"id": "C0282303", "name": "C0282303#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1413950", "name": "C1413950#ent", "pos": [28, 29]}}
{"token": ["The", "cytosolic", "domain", "C1425230#ent", "<e1>", "appears", "to", "function", "as", "a", "receptor", "in", "cooperation", "with", "C3890381#ent", "<e2>", ",", "but", "how", "its", "substrate", "specificity", "differs", "from", "that", "of", "C3890381#ent", "<e2>", "remains", "unclear", "."], "h": {"id": "C1425230", "name": "C1425230#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3890381", "name": "C3890381#ent", "pos": [14, 15]}}
{"token": ["C1425230#ent", "<e1>", "forms", "a", "complex", "with", "C3890381#ent", "<e2>", ",", "and", "its", "cytosolic", "domain", "as", "an", "import", "receptor", "in", "fungi", "."], "h": {"id": "C1425230", "name": "C1425230#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890381", "name": "C3890381#ent", "pos": [6, 7]}}
{"token": ["Pharmacological", "characterization", "in", "the", "fasted", "state", "that", "the", "contraction-stimulating", "activity", "TKS159", "and", "cisapride", "on", "the", "stomach", "was", "significantly", "inhibited", "by", "C0004259#ent", "<e1>", ",", "hexamethonium", "and", "a", "C2936527#ent", "<e2>", "SDZ", "205", "-", "557", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2936527", "name": "C2936527#ent", "pos": [26, 27]}}
{"token": ["To", "study", "the", "role", "of", "protein", "phosphorylation", "erythropoietin", "(EPO)-mediated", "signal", "transduction", "we", "examined", "the", "effects", "of", "C1430988#ent", "<e1>", "tyrosine", "and", "serine-threonine", "kinase", "inhibitors", "well", "as", "activators", "of", "C0031727#ent", "<e2>", "DNA", "synthesis", "cell", "proliferation", "the", "murine", "EPO-dependent", "cell", "line", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [27, 28]}}
{"token": ["Clinical", "analysis", "that", "there", "are", "many", "distinct", "forms", "with", "or", "without", "C0452138#ent", "<e1>", "and", "with", "early", "or", "late", "occurrence", "of", "C2316810#ent", "<e2>"], "h": {"id": "C0452138", "name": "C0452138#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [20, 21]}}
{"token": ["A", "study", "was", "carried", "out", "to", "compare", "the", "efficacy", "and", "tolerability", "of", "C0059865#ent", "<e1>", "and", "piroxicam", "in", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["We", "compared", "the", "longterm", "efficacy", "and", "safety", "of", "2", "dosages", "of", "C0059865#ent", "<e1>", "with", "that", "of", "ibuprofen", "in", "the", "treatment", "of", "active", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [24, 25]}}
{"token": ["We", "compared", "the", "longterm", "efficacy", "and", "safety", "of", "2", "dosages", "of", "C0059865#ent", "<e1>", "with", "that", "of", "ibuprofen", "in", "the", "treatment", "of", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}}
{"token": ["Pre-treating", "endothelial", "cells", "AZD3582", "at", "concentrations", "that", "were", "effective", "at", "inducing", "C1415619#ent", "<e1>", "also", "reduced", "C2604870#ent", "<e2>", "production", "of", "oxygen", "radicals"], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2604870", "name": "C2604870#ent", "pos": [15, 16]}}
{"token": ["Herein", ",", "we", "present", "the", "effects", "of", "voluntary", "exercise", "the", "MC4R", "knockout", "mice", "terms", "of", "bypassing", "the", "C0028754#ent", "<e1>", "hyperphagia", "phenotypes", "associated", "with", "C0028754#ent", "<e1>", "."], "h": {"id": "C0028754", "name": "C0028754#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [17, 18]}}
{"token": ["Each", "child", "received", "C1417487#ent", "<e1>", "alone", "during", "one", "course", ",", "and", "C1417487#ent", "<e1>", "with", "C0041044#ent", "<e1>", "during", "the", "next", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [14, 15]}}
{"token": ["Diffuse", "musculoskeletal", "aching", "accompanied", "by", "multiple", "C1335824#ent", "<e1>", "in", "the", "absence", "of", "an", "underlying", "C0003864#ent", "<e2>", "or", "systemic", "condition", "are", "the", "key", "features", "for", "diagnosis", "."], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "we", "demonstrate", "that", "C0968383#ent", "<e1>", "is", "a", "partial", "C2987634#ent", "<e2>", "of", "human", "AhR", ",", "which", "induces", "CYP1A", "genes"], "h": {"id": "C0968383", "name": "C0968383#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "coordinate", "activity", "both", "the", "p38", "and", "C1708804#ent", "<e1>", "pathways", "appears", "necessary", "for", "optimal", "transcription", "of", "C0162508#ent", "<e2>", "and", ",", "pari", "pasu", ",", "VSMC", "proliferation", "."], "h": {"id": "C1708804", "name": "C1708804#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "the", "use", "of", "dominant", "interfering", "molecules", "that", "Cot", "requires", "JNK", ",", "p38s", ",", "and", "C1708804#ent", "<e1>", "to", "stimulate", "the", "C0162508#ent", "<e2>", "promoter", "fully", "and", "to", "induce", "neoplastic", "transformation"], "h": {"id": "C1708804", "name": "C1708804#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [21, 22]}}
{"token": ["A", "crude", "extract", "of", "the", "C0027203#ent", "<e1>", "obtained", "from", "the", "livers", "of", "F344", "rats", "preadministered", "C0020789#ent", "<e2>", "7", "days", "before", "they", "were", "sacrificed", "showed", "higher", "enzymatic", "activity", "that", "from", "non-preadministered", "rats", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020789", "name": "C0020789#ent", "pos": [15, 16]}}
{"token": ["Con", "A-stimulated", "bulk", "spleen", "cell", "cultures", "from", "C0879590#ent", "<e1>", "C1416746#ent", "<e2>", "mice", "were", "essentially", "devoid", "not", "only", "of", "C0879590#ent", "<e1>", "but", "also", "IL-7", "gene", "transcripts", "."], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [7, 8]}}
{"token": ["To", "understand", "regulated", "mRNA", "decay", "in", "Archaea", ",", "we", "need", "to", "identify", "stability", "determinants", "within", "mRNAs", "and", "C0086376#ent", "<e1>", ",", "mainly", "ribonucleases", "(", "C0035541#ent", "<e2>", ")", ",", "which", "recognize", "these", "determinants", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [23, 24]}}
{"token": ["By", "separating", "the", "basic", "C0086376#ent", "<e1>", ",", "only", "two", "C0086376#ent", "<e1>", ",", "C0035541#ent", "<e1>", "seminal", "antimicrobial", "protein", "found", "to", "be", "active", "in", "inhibition", "of", "lymphocyte", "proliferation"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [12, 13]}}
{"token": ["Instead", "of", "INH", "and", "C3272713#ent", "<e1>", "a", "combined", "C0013227#ent", "<e2>", "was", "given", "--", "RIFAMAZIDE", "(", "Polfa", ")", "."], "h": {"id": "C3272713", "name": "C3272713#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}}
{"token": ["Emphasis", "was", "placed", "on", "the", "neurological", "features", "the", "relationship", "between", "C0242350#ent", "<e1>", "and", "the", "bladder", "dysfunction", "C0026769#ent", "<e2>"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [16, 17]}}
{"token": ["The", "promoter", ",", "C1412821#ent", "<e1>", "ORF", ")", "and", "C3205287#ent", "<e2>", "are", "amplified", "using", "Pfu", "or", "Taq", "DNA", "polymerase"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3205287", "name": "C3205287#ent", "pos": [8, 9]}}
{"token": ["Another", "C1412821#ent", "<e1>", "called", "the", "terminator", "peptide", "starts", "after", "the", "C3205287#ent", "<e2>", "and", "covers", "about", "half", "the", "distance", "to", "pheS", ",", "the", "first", "structural", "gene", "the", "operon", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3205287", "name": "C3205287#ent", "pos": [10, 11]}}
{"token": ["Following", "silencing", "of", "ASB", "or", "C0086651#ent", "<e1>", ",", "total", "sGAG", ",", "C4283853#ent", "<e2>", ",", "and", "CS", "increased", "significantly", "."], "h": {"id": "C0086651", "name": "C0086651#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [11, 12]}}
{"token": ["Following", "overexpression", "of", "ASB", "or", "C0086651#ent", "<e1>", ",", "total", "sGAG", ",", "C4283853#ent", "<e2>", ",", "and", "CS", "declined", "significantly", "."], "h": {"id": "C0086651", "name": "C0086651#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [11, 12]}}
{"token": ["The", "drugs", "investigated", "for", "safety", "were", "C0003364#ent", "<e1>", ",", "digoxin", ",", "oral", "contraceptives", "anticoagulants", "and", "C4048284#ent", "<e2>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "establish", "the", "correlation", "of", "the", "characteristics", "of", "patients", "with", "hypertension", "to", "C0003364#ent", "<e1>", "and", "the", "intake", "of", "C4048284#ent", "<e2>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [24, 25]}}
{"token": ["As", "with", "other", "HIV", "protease", "inhibitors", "C0286737#ent", "<e1>", "inhibits", "the", "cleavage", "of", "the", "C0016925#ent", "<e2>", "to", "the", "release", "of", "structurally", "defective", "and", "functionally", "inactive", "viral", "particles"], "h": {"id": "C0286737", "name": "C0286737#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016925", "name": "C0016925#ent", "pos": [13, 14]}}
{"token": ["Taken", "together", ",", "our", "findings", "suggest", "that", "activated", "C1417708#ent", "<e1>", "induced", "by", "the", "crosstalk", "between", "TNF", "and", "C1415900#ent", "<e2>", "is", "a", "novel", "pro-apoptotic", "signal", "acting", "via", "enhancement", "of", "Fas", "expression", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [17, 18]}}
{"token": ["The", "expression", "of", "IkappaB-alphaDN", "protein", "not", "inhibit", "the", "constitutive", "C1417708#ent", "<e1>", "but", "it", "inhibited", "cell", "proliferation", "antiproliferative", "response", "to", "C1415900#ent", "<e2>", ",", "and", "phosphorylated", "mitogen", "activated", "protein", "kinase", "(", "p-MAPK", ")", "level", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "short", "children", "classic", "C0035078#ent", "<e1>", "well", "to", "exogenous", "C1333673#ent", "<e2>", "in", "the", "short", "term", "return", "to", "pretreatment", "height", "velocities", "afterwards", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [12, 13]}}
{"token": ["The", "discovery", "of", "multiple", "pathogenic", "tau", "gene", "mutations", "in", "many", "kindreds", "with", "familial", "frontotemporal", "dementia", "C0242422#ent", "<e1>", "linked", "to", "chromosome", "17", "C0338451#ent", "<e2>", ")", "unequivocally", "confirmed", "the", "central", "role", "of", "tau", "abnormalities", "the", "etiology", "of", "neurodegenerative", "disorders"], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0338451", "name": "C0338451#ent", "pos": [21, 22]}}
{"token": ["Those", "sero-positive", "patients", "consisted", "of", "four", "cases", "with", "IgG", "antibodies", "mainly", "to", "the", "C3539699#ent", "<e1>", "C1704968#ent", "<e2>", ",", "four", "with", "IgM", "antibodies", "to", "the", "C3539699#ent", "<e1>", "p19", ",", "and", "three", "with", "both", "IgG", "and", "IgM", "antibodies"], "h": {"id": "C1704968", "name": "C1704968#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [13, 14]}}
{"token": ["In", "one", "patient", "relative", "resistance", "to", "C0037982#ent", "<e1>", "was", "attributed", "to", "exaggerated", "C0020428#ent", "<e2>", "induced", "by", "the", "drug", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0020428", "name": "C0020428#ent", "pos": [12, 13]}}
{"token": ["C0037982#ent", "<e1>", "and", "Ca", "antagonists", "used", "in", "patients", "with", "C0020428#ent", "<e2>", "bilateral", "hyperplasia", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020428", "name": "C0020428#ent", "pos": [9, 10]}}
{"token": ["Ongoing", "study", "in", "the", "appropriate", "use", "of", "C0114346#ent", "<e1>", "is", "needed", "to", "maximize", "its", "value", "as", "a", "C1519837#ent", "<e2>", "the", "clinical", "setting"], "h": {"id": "C0114346", "name": "C0114346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1519837", "name": "C1519837#ent", "pos": [17, 18]}}
{"token": ["Various", "doses", "and", "schedules", "of", "oral", "mesna", "usually", "in", "combination", "with", "intravenously", "injected", "C0114346#ent", "<e1>", ",", "provided", "effective", "C1519837#ent", "<e2>", "for", "a", "wide", "range", "of", "ifosfamide", "regimens"], "h": {"id": "C0114346", "name": "C0114346#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1519837", "name": "C1519837#ent", "pos": [18, 19]}}
{"token": ["These", "included", "verapamil", "(", "arrhythmia", ")", ",", "isosorbide", "dinitrate", "angina", ")", ",", "C0004147#ent", "<e1>", "(", "hypertension", ")", "and", "enalapril", "(", "C0018802#ent", "<e2>", "."], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["Among", "the", "up-regulated", "C1417679#ent", "<e1>", ",", "many", "C1417679#ent", "<e1>", "involved", "in", "tissue", "remodeling", "Spi15", ",", "Serpine1", "and", "C1414830#ent", "<e1>", ")", "and", "cellular", "growth", "Bdnf", ",", "Ros1", "and", "Fgf10", ")", "were", "present", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414830", "name": "C1414830#ent", "pos": [17, 18]}}
{"token": ["In", "situ", "hybridization", "immunohistochemistry", "were", "used", "for", "detecting", "the", "expression", "of", "C1417679#ent", "<e1>", "encoding", "inhibin/activin", "subunits", "and", "C1414830#ent", "<e2>", "and", "their", "gene", "products", "the", "proteins", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414830", "name": "C1414830#ent", "pos": [17, 18]}}
{"token": ["Erf2", "palmitoylates", "yeast", "C0080058#ent", "<e1>", "whereas", "Akr1", "modifies", "the", "C0054846#ent", "<e2>", "Yck2", "."], "h": {"id": "C0080058", "name": "C0080058#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0054846", "name": "C0054846#ent", "pos": [9, 10]}}
{"token": ["The", "present", "data", "provide", "evidence", "that", "C0136134#ent", "<e1>", "is", "required", "for", "binding", "and", "concentrating", "C1420884#ent", "<e2>", "at", "the", "apical", "surface", "of", "vascular", "endothelial", "cells", "receptor-mediated", "endocytosis"], "h": {"id": "C0136134", "name": "C0136134#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420884", "name": "C1420884#ent", "pos": [14, 15]}}
{"token": ["However", ",", "only", "10/58", "fa/fa", "animals", "were", "homozygous", "for", "the", "13", "M", "CRF", "C0002085#ent", "<e1>", ",", "indicating", "that", "C0015625#ent", "<e2>", "and", "CRF", "are", "not", "allelic", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [18, 19]}}
{"token": ["Four", "C0003211#ent", "<e1>", "with", "enoxacin", "at", "100", "mg/kg", "also", "caused", "C0036572#ent", "<e2>", "dose-dependently", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}}
{"token": ["Three", "patients", "with", "C0002962#ent", "<e1>", "resistant", "to", "therapy", "with", "nitrates", "and", "C0033497#ent", "<e2>", "were", "treated", "with", "perhexilene", "maleate", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [11, 12]}}
{"token": ["The", "Asp312Asn", "and", "Lys751Gln", "polymorphisms", "in", "the", "xeroderma", "pigmentosum", "C0004135#ent", "<e1>", "XPD", ")", "gene", "may", "alter", "C1333237#ent", "<e2>", "capacity", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [16, 17]}}
{"token": ["The", "gene", "mutated", "C0004135#ent", "<e1>", "ATM", ",", "on", "human", "chromosome", "11q22-q23", "implicated", "in", "cell", "cycle", "control", "C1333237#ent", "<e2>"], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [16, 17]}}
{"token": ["Real-time", "biomolecular", "interaction", "analysis", "demonstrated", "that", "the", "interaction", "of", "C1705543#ent", "<e1>", "with", "fibrinogen", ",", "fibronectin", ",", "and", "C1336937#ent", "<e2>", "is", "dose", "dependent", "and", "saturable", "and", "occurs", "with", "a", "high", "affinity", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1336937", "name": "C1336937#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "C0061231#ent", "<e1>", "was", "more", "effective", "than", "gefarnate", "for", "the", "treatment", "of", "C0017152#ent", "<e2>", "."], "h": {"id": "C0061231", "name": "C0061231#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [15, 16]}}
{"token": ["The", "chi", "form", "of", "C0001942#ent", "<e1>", "showed", "no", "structural", "resemblance", "to", "the", "C1412235#ent", "<e2>", ",", "ADH2", "and", "ADH3", "(", "class", "I", "or", "ADH4", "(", "class", "II", "isozymes", ",", "as", "judged", "by", "its", "immunological", "properties"], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412235", "name": "C1412235#ent", "pos": [12, 13]}}
{"token": ["C0907533#ent", "<e1>", "active", "forms", "BMP", "type", "I", "receptors", "BMPR-IA", "and", "BMPR-IB", ")", "and", "those", "of", "C1366767#ent", "<e2>", "ALK-2", "maintained", "differentiation", "of", "chondrocytes", "in", "the", "presence", "of", "retinoic", "acid"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366767", "name": "C1366767#ent", "pos": [15, 16]}}
{"token": ["No", "isomers", "C1413904#ent", "<e1>", "were", "detected", "in", "S.", "bovis", "P.", "ruminicola", "two", "of", "the", "bacterial", "C1875400#ent", "<e2>", "."], "h": {"id": "C1413904", "name": "C1413904#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [15, 16]}}
{"token": ["Metal", "ion-chelating", "agents", "inhibited", "C1418457#ent", "<e1>", "a", "rat", "striatal", "C1366499#ent", "<e2>", "'", "enkephalinase", "'", "."], "h": {"id": "C1418457", "name": "C1418457#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366499", "name": "C1366499#ent", "pos": [9, 10]}}
{"token": ["Increased", "expression", "of", "C1422017#ent", "<e1>", "displaces", "some", "C3274849#ent", "<e2>", "to", "a", "100", "000", "x", "g", "supernatant", "and", "suppresses", "the", "dominant-negative", "phenotype", "."], "h": {"id": "C1422017", "name": "C1422017#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3274849", "name": "C3274849#ent", "pos": [7, 8]}}
{"token": ["Yeast", "Vps35p", "(", "C1422017#ent", "<e1>", ")", "exhibits", "similarity", "to", "human", "Vps35", "(", "C3274849#ent", "<e2>", ")", ",", "especially", "in", "a", "completely", "conserved", "PRLYL", "motif", "contained", "within", "an", "amino-terminal", "domain"], "h": {"id": "C1422017", "name": "C1422017#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3274849", "name": "C3274849#ent", "pos": [12, 13]}}
{"token": ["Although", "the", "aliphatic", "fraction", "failed", "to", "perturb", "mitochondrial", "function", "the", "C0772162#ent", "<e1>", "increased", "the", "C1413043#ent", "<e2>", "+", "retention", "capacity", "at", "low", "doses", "induced", "mitochondrial", "swelling", "a", "decrease", "in", "Delta-Psi", "m", "at", "high", "doses"], "h": {"id": "C0772162", "name": "C0772162#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "the", "C0256022#ent", "<e1>", "DNA", "cleavage", "patterns", "of", "XK469", "and", "C0049111#ent", "<e2>", "were", "very", "different", "from", "one", "another", "despite", "the", "similar", "overall", "structures", "of", "the", "two", "drugs", "."], "h": {"id": "C0256022", "name": "C0256022#ent", "pos": [4, 5]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0049111", "name": "C0049111#ent", "pos": [12, 13]}}
{"token": ["Since", "its", "inhibition", "is", "very", "potent", "and", "has", "a", "broad", "\"", "window", "of", "selectivity", ",", "\"", "C0028978#ent", "<e1>", "seems", "to", "be", "a", "useful", ",", "selective", "inhibitor", "of", "C0960580#ent", "<e2>", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [16, 17]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [27, 28]}}
{"token": ["To", "explore", "the", "potential", "interactions", "between", "yin", "zhi", "huang", "YZH", ")", "and", "C0028978#ent", "<e1>", ",", "a", "substrate", "of", "CYP3A4", "and", "C0960580#ent", "<e2>", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [12, 13]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [20, 21]}}
{"token": ["C0019911#ent", "<e1>", "opisthorchiasis", ",", "strongyloidiasis", "and", "giardiasis", "were", "the", "leading", "C0747256#ent", "<e2>", "while", "amoebiasis", "was", "rare", "."], "h": {"id": "C0019911", "name": "C0019911#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [10, 11]}}
{"token": ["C0019911#ent", "<e1>", "an", "extremely", "rare", "cause", "of", "heart", "failure", "and", "furthermore", "this", "C0747256#ent", "<e2>", "not", "common", "in", "advanced", "countries"], "h": {"id": "C0019911", "name": "C0019911#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [12, 13]}}
{"token": ["C1366526#ent", "<e1>", "is", "the", "prototypical", "member", "of", "the", "C1420851#ent", "<e2>", "family", "and", "is", "known", "to", "be", "involved", "in", "cell", "growth", "differentiation", "and", "DNA", "repair"], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420851", "name": "C1420851#ent", "pos": [8, 9]}}
{"token": ["The", "non-specific", "IHD", "group", "showed", "the", "highest", "C2699120#ent", "<e1>", "values", ",", "while", "the", "C0340288#ent", "<e2>", "group", "showed", "the", "lowest", "."], "h": {"id": "C2699120", "name": "C2699120#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "a", "great", "number", "of", "non-digestive", "symptoms", "either", "pulmonary", ",", "C0720131#ent", "<e1>", ",", "or", "cardiac", ",", "are", "also", "connected", "with", "C0017168#ent", "<e2>", "."], "h": {"id": "C0720131", "name": "C0720131#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [21, 22]}}
{"token": ["C1333578#ent", "<e1>", "is", "an", "C1332163#ent", "<e2>", "links", "FGFRs", "to", "the", "mitogen-activated", "protein", "kinase", "signaling", "pathway"], "h": {"id": "C1333578", "name": "C1333578#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332163", "name": "C1332163#ent", "pos": [4, 5]}}
{"token": ["C0546863#ent", "<e1>", "is", "commonly", "used", "for", "the", "treatment", "of", "tuberculous", "and", "C0026919#ent", "<e2>"], "h": {"id": "C0546863", "name": "C0546863#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0026919", "name": "C0026919#ent", "pos": [11, 12]}}
{"token": ["We", "report", "our", "experience", "with", "rapid", "oral", "desensitization", "C0546863#ent", "<e1>", "and", "rifampin", "in", "a", "group", "of", "10", "patients", "with", "C0026919#ent", "<e2>", "had", "experienced", "cutaneous", "hypersensitivity", "reactions", "these", "drugs", "."], "h": {"id": "C0546863", "name": "C0546863#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0026919", "name": "C0026919#ent", "pos": [19, 20]}}
{"token": ["Chlorpromazine", ",", "melperone", ",", "diazepam", ",", "mebumal", ",", "C0022614#ent", "<e1>", "and", "ethanol", "all", "inhibited", "CT-induced", "C0037036#ent", "<e2>", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037036", "name": "C0037036#ent", "pos": [15, 16]}}
{"token": ["One", "daily", "dose", "of", "0.05", "mg", "C0025506#ent", "<e1>", "oestradiol", "was", "administered", "to", "5", "patients", "with", "C0019937#ent", "<e2>", "mean", "age", "/-", "SEM", "=", "16.4", "+", "/-", "0.7", "years", ")", "for", "10", "days", "."], "h": {"id": "C0025506", "name": "C0025506#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019937", "name": "C0019937#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", "our", "objective", "was", "to", "determine", "the", "prevalance", "of", "C1711373#ent", "<e1>", "a", "Turkish", "adult", "population", "with", "C0011860#ent", "<e2>"], "h": {"id": "C1711373", "name": "C1711373#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [18, 19]}}
{"token": ["Morbidity", "and", "mortality", "of", "chronic", "liver", "disease", "primarily", "caused", "by", "C0023890#ent", "<e1>", "portal", "hypertension", "both", "of", "them", "C1565107#ent", "<e2>", "progressive", "liver", "fibrosis"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1565107", "name": "C1565107#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "in", "patients", "with", "chronic", ",", "C0524851#ent", "<e1>", "particularly", "when", "associated", "with", "hepatic", "dysfunction", "the", "diagnosis", "of", "C0019202#ent", "<e2>", "be", "considered", "regardless", "of", "age", "at", "onset", "or", "the", "absence", "of", "Kayser-Fleischer", "rings", "slit", "lamp", "examination"], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [19, 20]}}
{"token": ["Forty", "patients", "with", "the", "acquired", "immunodeficiency", "syndrome", "AIDS", ")", "and", "their", "first", "episodes", "of", "C1535939#ent", "<e1>", "assigned", "at", "random", "to", "receive", "either", "trimethoprim-sulfamethoxazole", "or", "C0030864#ent", "<e2>"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [14, 15]}, "relation": "may_be_prevented_by", "t": {"id": "C0030864", "name": "C0030864#ent", "pos": [24, 25]}}
{"token": ["Historically", ",", "C0744471#ent", "<e1>", "been", "the", "most", "problematic", "C0004623#ent", "<e2>", "neutropenic", "patients", ",", "but", "its", "incidence", "has", "reduced", "over", "time", "because", "of", "the", "use", "of", "prophylactic", "antibiotics", "."], "h": {"id": "C0744471", "name": "C0744471#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [8, 9]}}
{"token": ["In", "two", "patients", "with", "C1561643#ent", "<e1>", "CRF", ")", "different", "effects", "of", "C0003015#ent", "<e2>", "ACEI", ")", "and", "angiotensin", "receptor", "1", "blockers", "AT1B", ")", "were", "observed", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [11, 12]}}
{"token": ["However", ",", "the", "C0947912#ent", "<e1>", "symptoms", "and", "serum", "acetylcholine", "receptor", "antibody", "following", "the", "discontinuation", "of", "C0031507#ent", "<e2>", "in", "our", "patient", "."], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [15, 16]}}
{"token": ["Her", "C0947912#ent", "<e1>", "signs", "had", "continued", "one", "month", "after", "C0031507#ent", "<e2>", "withdrawal", ",", "then", "an", "extended", "thymectomy", "was", "done", "."], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [9, 10]}}
{"token": ["Total", "intravenous", "anaesthesia", "midazolam", "and", "C0002026#ent", "<e1>", ",", "reversed", "with", "the", "benzodiazepine", "antagonist", "C0016293#ent", "<e2>", ",", "was", "studied", "in", "patients", "admitted", "for", "outpatient", "gynaecological", "dilatation", "curettage", "."], "h": {"id": "C0002026", "name": "C0002026#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016293", "name": "C0016293#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "total", "intravenous", "anaesthesia", "C0002026#ent", "<e1>", "and", "midazolam", "with", "C0016293#ent", "<e2>", "reversal", "is", "a", "promising", "technique", "for", "short", "outpatient", "anaesthetic", "procedures"], "h": {"id": "C0002026", "name": "C0002026#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016293", "name": "C0016293#ent", "pos": [11, 12]}}
{"token": ["Human", "endothelial", "cells", "cultured", "under", "high", "glucose", "HG", ")", "conditions", "were", "shown", "before", "to", "upregulate", "several", "basement", "membrane", "proteins", "including", "fibronectin", "(", "C1367472#ent", "<e1>", ")", ",", "thus", "mimicking", "effects", "of", "C0011847#ent", "<e2>", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [30, 31]}}
{"token": ["One", "C1706112#ent", "<e1>", ",", "reported", "originally", "in", "a", "French", "C0007427#ent", "<e2>", "patient", "(", "Akli", "et", "al.", ",", "1991", ")", ",", "is", "a", "GT-->AT", "transition", "at", "the", "donor", "splice-site", "of", "intron", "9"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [9, 10]}}
{"token": ["Inhibition", "with", "C0022625#ent", "<e1>", "showed", "that", "CYP3A", "is", "the", "high", "affinity", "enzyme", "for", "oxycodone", "N-demethylation", ";", "C0022625#ent", "<e1>", "inhibited", ">", "90", "%", "of", "C0030049#ent", "<e1>", "formation", "at", "low", "substrate", "concentrations", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030049", "name": "C0030049#ent", "pos": [23, 24]}}
{"token": ["In", "HEp2-alpha(v)beta(3", ")", "integrin-expressing", "cells", ",", "the", "constitutive", "expression", "of", "C4042483#ent", "<e1>", "the", "level", "of", "glutathione", "(", "C1260386#ent", "<e2>", ")", "were", "increased", "compared", "with", "HEp2", "cells", "."], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [17, 18]}}
{"token": ["Microdialysis", "studies", "revealed", "that", "this", "dose", "of", "C0700541#ent", "<e1>", "preferentially", "increased", "the", "release", "of", "dopamine", "in", "the", "C3889643#ent", "<e2>", "compared", "with", "the", "striatum", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889643", "name": "C3889643#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "suggest", "that", "deficient", "C1705924#ent", "<e1>", "is", "an", "intrinsic", "feature", "of", "C0002874#ent", "<e2>", "and", "that", "the", "circulating", "cells", "this", "disease", "are", "of", "the", "pre-NK", "cell", "stage", "."], "h": {"id": "C1705924", "name": "C1705924#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "C0304497#ent", "<e1>", "stopped", ",", "and", "the", "dosage", "of", "C3540725#ent", "<e2>", "lowered", "."], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [10, 11]}}
{"token": ["Most", "required", "C0304497#ent", "<e1>", "surgery", "or", "radiotherapy", "in", "addition", "to", "C3540725#ent", "<e2>", "."], "h": {"id": "C0304497", "name": "C0304497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [10, 11]}}
{"token": ["While", "there", "is", "no", "detectable", "immune", "response", "C0036457#ent", "<e1>", "infection", ",", "the", "possibility", "that", "increased", "C0024518#ent", "<e2>", "expression", "affords", "some", "defense", "against", "the", "C0036457#ent", "<e1>", "agent", "is", "discussed", "."], "h": {"id": "C0036457", "name": "C0036457#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [15, 16]}}
{"token": ["Salicylates", ",", "C0021246#ent", "<e1>", ",", "phenylbutazone", "and", "C0020336#ent", "<e2>", "produce", "some", "clinical", "improvement", "do", "not", "lower", "the", "high", "ESR", ";", "moreover", ",", "the", "patients", "are", "prone", "to", "experience", "relapses", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [7, 8]}}
{"token": ["The", "related", "C1414058#ent", "<e1>", ",", "however", ",", "can", "function", "either", "as", "LRP6", "C2987634#ent", "<e2>", "or", "antagonist", ",", "depending", "on", "the", "cellular", "context", "suggesting", "that", "its", "activity", "is", "modulated", "by", "unknown", "co-factors", "."], "h": {"id": "C1414058", "name": "C1414058#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [12, 13]}}
{"token": ["C0812246#ent", "<e1>", "is", "a", "primary", "cytokine", "and", "is", "elevated", "in", "C4284230#ent", "<e2>", ",", "and", "specific", "inhibition", "of", "C0812246#ent", "<e1>", "in", "this", "patient", "was", "effective", "in", "moderating", "his", "disease", ",", "including", "his", "skin", "disease"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4284230", "name": "C4284230#ent", "pos": [10, 11]}}
{"token": ["C0030306#ent", "<e1>", "and", "alkaline", "protease", "not", "cause", "release", "of", "marker", "C3540790#ent", "<e2>", "and", "did", "not", "directly", "inhibit", "the", "bactericidal", "activity", "polymorphonuclear", "leukocytes", "killing", "was", "reduced", "due", "to", "inactivation", "of", "complement", "components"], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "although", "C0008312#ent", "<e1>", "is", "effective", "in", "controlling", "ongoing", "C0036572#ent", "<e2>", ",", "the", "therapy", "frequently", "leads", "to", "significant", "hypotension", "."], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}}
{"token": ["C0008312#ent", "<e1>", "was", "extremely", "effective", "in", "aborting", "C0036572#ent", "<e2>", "in", "16", "of", "17", "patients", ",", "but", "11", "of", "the", "patients", "developed", "severe", "hypotension", "that", "required", "therapy", "with", "vasopressors", "."], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [7, 8]}}
{"token": ["Patients", "with", "the", "following", "conditions", "were", "excluded", ":", "myocardial", "infarction", "C0002962#ent", "<e1>", "liver", "disease", "malignant", "neoplasms", "enforced", "physical", "activity", "skeletal", "muscle", "trauma", "myositis", ",", "rhabdomyolysis", "and", "C0751495#ent", "<e2>", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [26, 27]}}
{"token": ["Movement", "disorders", "well", "known", "features", "of", "some", "dominant", "C0004138#ent", "<e1>", "HA", ")", ",", "specially", "C0024408#ent", "<e2>", "dentatorubropallidolusyan", "atrophy"], "h": {"id": "C0004138", "name": "C0004138#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024408", "name": "C0024408#ent", "pos": [14, 15]}}
{"token": ["Forty-two", "patients", "with", "unilateral", "vestibular", "neuronitis", "examined", "by", "the", "combined", "galvanic", "test", "(", "C0006698#ent", "<e1>", ")", ",", "consisting", "of", "the", "galvanic", "eye", "movement", "test", "C1567665#ent", "<e2>", ")", "and", "the", "galvanic", "body", "sway", "test", "(", "GBST", ")", "."], "h": {"id": "C0006698", "name": "C0006698#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1567665", "name": "C1567665#ent", "pos": [24, 25]}}
{"token": ["We", "conclude", "that", "inhibition", "of", "C1620185#ent", "<e1>", "by", "fluvoxamine", "considerably", "reduces", "elimination", "of", "C0073571#ent", "<e2>", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0073571", "name": "C0073571#ent", "pos": [13, 14]}}
{"token": ["This", "model", "supposes", "that", "C0016053#ent", "<e1>", "and", "CFS", "are", "central", "processing", "problems", "rather", "than", "C1704436#ent", "<e2>", "muscles", "and", "joints", "."], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [14, 15]}}
{"token": ["Using", "the", "autoradiographic", "deoxyglucose", "method", ",", "local", "consumption", "glucose", "has", "been", "visualized", "during", "C0751494#ent", "<e1>", "induced", "by", "systemic", "administration", "C0022471#ent", "<e2>", "bicuculline", "or", "metrazol", "."], "h": {"id": "C0751494", "name": "C0751494#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [19, 20]}}
{"token": ["The", "calcium-channel", "blocker", "C0028005#ent", "<e1>", "showed", "the", "higher", "C0035379#ent", "<e2>", "ability", "when", "compared", "to", "cefoperazone", "or", "cyclosporin", "A", "at", "concentrations", "close", "to", "the", "pharmacological", "range"], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [8, 9]}}
{"token": ["Using", "small", "interfering", "RNA", "to", "suppress", "endogenous", "ubiquitin", "expression", "and", "C3537238#ent", "<e1>", "repress", "ubiquitin-mediated", "protein", "degradation", "we", "showed", "that", "HMGA2", "confers", "C1705330#ent", "<e2>", "down-regulation", "through", "ubiquitin-proteasome-dependent", "protein", "degradation", "."], "h": {"id": "C3537238", "name": "C3537238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705330", "name": "C1705330#ent", "pos": [21, 22]}}
{"token": ["The", "C1336677#ent", "<e1>", "core", "region", "approximately", "5.8", "kb", ",", "including", "the", "C1417679#ent", "<e2>", "traF", ",", "-G", ",", "-H", ",", "-I", ",", "-J", ",", "and", "-K", "as", "well", "as", "the", "origin", "of", "transfer", "."], "h": {"id": "C1336677", "name": "C1336677#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["TBNA", "was", "not", "helpful", "in", "other", "diseases", "including", "C1535939#ent", "<e1>", "infection", "with", "Cryptococcus", "or", "Nocardia", ",", "bacterial", "pneumonia", "C0032285#ent", "<e2>", "and", "Kaposi's", "sarcoma"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [18, 19]}}
{"token": ["Several", "of", "the", "STAT5b-dependent", "male", "C1417679#ent", "<e1>", "encode", "transcriptional", "repressors", "these", "may", "include", "direct", "C1335876#ent", "<e2>", "targets", "that", "repress", "female-predominant", "genes", "in", "male", "liver", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335876", "name": "C1335876#ent", "pos": [14, 15]}}
{"token": ["These", "electrophysiological", "manifestations", "hypothalamic", "LHRH", "pulse", "generator", "activity", "were", "inhibited", "by", "the", "alpha-adrenergic", "blocker", "C0733398#ent", "<e1>", "or", "the", "alpha", "1-adrenoceptor", "blockers", "C0031441#ent", "<e2>", "and", "prazosin", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031441", "name": "C0031441#ent", "pos": [21, 22]}}
{"token": ["A", "C0221777#ent", "<e1>", "mutant", "of", "Stxl", "which", "lacks", "N-glycosidase", "activity", "not", "induce", "C1333196#ent", "<e2>", "mRNAs", "."], "h": {"id": "C0221777", "name": "C0221777#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [12, 13]}}
{"token": ["Biallele", "and", "triallele", "polymorphism", "C0031653#ent", "<e1>", "in", "three", "of", "the", "C0014894#ent", "<e2>", "determined", "."], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014894", "name": "C0014894#ent", "pos": [10, 11]}}
{"token": ["Using", "clonogenic", "survival", "assays", "the", "C3887634#ent", "<e1>", "apoptosis", ",", "we", "demonstrated", "that", "preirradiation", "treatment", "with", "C0678021#ent", "<e2>", "significantly", "increased", "the", "radiosensitivity", "of", "A431", "cells", "over", "controls", "."], "h": {"id": "C3887634", "name": "C3887634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0678021", "name": "C0678021#ent", "pos": [15, 16]}}
{"token": ["By", "application", "of", "this", "assay", ",", "it", "was", "possible", "to", "show", "that", "C3887685#ent", "<e1>", "formation", "was", "competitively", "inhibited", "by", "C0037760#ent", "<e2>", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0037760", "name": "C0037760#ent", "pos": [19, 20]}}
{"token": ["The", "urinary", "ratio", "debrisoquine/4-hydroxy-debrisoquine", ",", "reflecting", "the", "individual's", "capacity", "to", "C3887685#ent", "<e1>", "was", "closely", "related", "to", "his", "phenotype", "for", "C0037760#ent", "<e2>", "metabolism", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037760", "name": "C0037760#ent", "pos": [19, 20]}}
{"token": ["Myosin", "kinase", "phosphatase", ",", "phosphorylating", "and", "C0027120#ent", "<e1>", "are", "the", "key", "regulatory", "C3540790#ent", "<e2>", "of", "smooth", "muscle"], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}}
{"token": ["When", "CaM-binding", "domains", "were", "removed", "from", "calcineurin", "and", "C0027120#ent", "<e1>", "the", "resultant", "C3540790#ent", "<e2>", "no", "longer", "exposed", "new", "domains", "in", "response", "to", "H+", "increase", "."], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}}
{"token": ["A", "common", "insertion/deletion", "polymorphism", "in", "the", "C1337106#ent", "<e1>", "of", "the", "promoter", "region", "C1567723#ent", "<e2>", "results", "in", "decreased", "initiation", "of", "transcription", "."], "h": {"id": "C1337106", "name": "C1337106#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1567723", "name": "C1567723#ent", "pos": [12, 13]}}
{"token": ["Recent", "studies", "have", "shown", "that", "a", "variant", "C1337106#ent", "<e1>", "in", "the", "promoter", "region", "the", "UDP-glucuronosyltransferase", "1A1", "C1567723#ent", "<e2>", ")", "gene", "is", "associated", "with", "development", "of", "cholelithiasis", "."], "h": {"id": "C1337106", "name": "C1337106#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1567723", "name": "C1567723#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "we", "hypothesized", "that", "C1705644#ent", "<e1>", "participates", "in", "the", "C1710463#ent", "<e2>", "CTSS", "in", "these", "cells", "."], "h": {"id": "C1705644", "name": "C1705644#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [10, 11]}}
{"token": ["Combination", "therapy", "a", "C0354100#ent", "<e1>", "an", "aldosterone", "antagonist", "produce", "normokalemic", "hypochloremic", "C0002063#ent", "<e2>", ",", "a", "complication", "not", "previously", "documented", "in", "the", "literature", "."], "h": {"id": "C0354100", "name": "C0354100#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002063", "name": "C0002063#ent", "pos": [11, 12]}}
{"token": ["Bacterial", "vaginosis", "nonspecific", "C0085166#ent", "<e1>", ")", "is", "a", "C0275524#ent", "<e2>", ",", "superficial", "vaginal", "infection", "by", "an", "increase", "in", "anaerobic", "organisms", "and", "a", "concomitant", "decrease", "in", "lactobacilli", "."], "h": {"id": "C0085166", "name": "C0085166#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [8, 9]}}
{"token": ["In", "our", "series", "26", "were", "C0947912#ent", "<e1>", "patients", ",", "4", "patients", "presented", "C0018378#ent", "<e2>", "and", "1", "multiple", "sclerosis"], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [12, 13]}}
{"token": ["Our", "microarray", "analysis", "a", "major", "role", "in", "longevity", "assurance", "of", "the", "phase", "1", "phase", "2", "detoxification", "system", "cytochrome", "P450", "CYP", ")", ",", "C1425705#ent", "<e1>", "SDR", ")", "and", "C1259497#ent", "<e2>", "(", "UGT", ")", "enzymes", "."], "h": {"id": "C1425705", "name": "C1425705#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1259497", "name": "C1259497#ent", "pos": [27, 28]}}
{"token": ["Lys81Glu", "(", "c.241A", ">", "G", ")", "missense", "mutation", "in", "the", "C2746066#ent", "<e1>", "confirming", "the", "diagnosis", "of", "C1855995#ent", "<e2>"], "h": {"id": "C2746066", "name": "C2746066#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1855995", "name": "C1855995#ent", "pos": [16, 17]}}
{"token": ["C2746066#ent", "<e1>", "LGA", ")", "is", "the", "biochemical", "hallmark", "of", "C1855995#ent", "<e2>", "L-OHGA", ")", ",", "an", "inherited", "neurometabolic", "disorder", "by", "progressive", "neurodegeneration", "with", "cerebellar", "and", "pyramidal", "signs", ",", "mental", "deterioration", "epilepsy", ",", "and", "subcortical", "leukoencephalopathy"], "h": {"id": "C2746066", "name": "C2746066#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1855995", "name": "C1855995#ent", "pos": [9, 10]}}
{"token": ["C0030424#ent", "<e1>", "one", "of", "the", "most", "important", "endemic", "C0030499#ent", "<e2>", "Korea", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [8, 9]}}
{"token": ["Dental", "and", "C0744403#ent", "<e1>", "patients", "with", "cardiac", "problems", "lead", "to", "C1541923#ent", "<e2>"], "h": {"id": "C0744403", "name": "C0744403#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1541923", "name": "C1541923#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "we", "considered", "the", "possibility", "that", "these", "C0031727#ent", "<e1>", "might", "be", "substrates", "for", "C1368803#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1368803", "name": "C1368803#ent", "pos": [14, 15]}}
{"token": ["C0040779#ent", "<e1>", "but", "not", "C0917964#ent", "<e2>", "suppressed", "PDGF-stimulated", "RhoA", "activation", "."], "h": {"id": "C0040779", "name": "C0040779#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [4, 5]}}
{"token": ["We", "report", "two", "cases", "of", "C0276758#ent", "<e1>", "evidence", "of", "C0085082#ent", "<e2>", "in", "severely", "neutropenic", "patients", "with", "leukaemia", "."], "h": {"id": "C0276758", "name": "C0276758#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085082", "name": "C0085082#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "C0276758#ent", "<e1>", "manifest", "with", "C0085082#ent", "<e2>", "and", "fever", "as", "the", "only", "symptoms", ",", "should", "be", "taken", "into", "consideration", "in", "neutropenic", "patients", "receiving", "immunosuppressive", "therapy"], "h": {"id": "C0276758", "name": "C0276758#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085082", "name": "C0085082#ent", "pos": [7, 8]}}
{"token": ["Several", "epidemiological", "studies", "sensitive", "detection", "methodologies", "have", "confirmed", "that", "the", "majority", "of", "C0582415#ent", "<e1>", "exacerbations", "follow", "upper", "respiratory", "tract", "infections", "common", "C0009443#ent", "<e2>", "."], "h": {"id": "C0582415", "name": "C0582415#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [21, 22]}}
{"token": ["Persistent", "hyperinsulinemic", "C0020615#ent", "<e1>", "of", "infancy", "(", "PHHI", ")", "is", "a", "C0021290#ent", "<e2>", "characterized", "by", "dysregulation", "of", "insulin", "secretion", "by", "profound", "C0020615#ent", "<e1>", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0021290", "name": "C0021290#ent", "pos": [11, 12]}}
{"token": ["Similarly", "TGF-beta", "binding", "proteins", "decorin", ",", "antagonistic", "cytokines", "such", "as", "bone", "morphogenetic", "protein-7", "C1442521#ent", "<e1>", "IL-10", ",", "or", "IFN-gamma", "were", "as", "efficient", "as", "C0108225#ent", "<e2>", "a", "protease", "inhibitor", "possibly", "abrogated", "proteolytic", "activation", "TGF-beta", "."], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0108225", "name": "C0108225#ent", "pos": [23, 24]}}
{"token": ["This", "review", "summarizes", "the", "evidence", "that", "points", "to", "a", "significant", "role", "for", "C1824669#ent", "<e1>", "in", "a", "range", "of", "pathological", "processes", "describes", "how", "C1824669#ent", "<e1>", "might", "exert", "its", "effects", "by", "C2712370#ent", "<e1>", "signal", "transduction", "antigen", "presentation", "pathways"], "h": {"id": "C1824669", "name": "C1824669#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [29, 30]}}
{"token": ["Damaging", "5-HTergic", "neurons", "by", "intracerebroventricular", "infusion", "of", "C0000543#ent", "<e1>", "(", "5,7-DHT", ")", "abolished", "the", "effect", "of", "C0085260#ent", "<e2>", "on", "ethanol", "consumption", "."], "h": {"id": "C0000543", "name": "C0000543#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085260", "name": "C0085260#ent", "pos": [16, 17]}}
{"token": ["The", "response", "induced", "by", "AngII", "was", "blocked", "by", "[", "C1419815#ent", "<e1>", ",", "Ile8]-AngII", "and", "that", "of", "NA", "was", "blocked", "by", "C0733398#ent", "<e2>", "."], "h": {"id": "C1419815", "name": "C1419815#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0733398", "name": "C0733398#ent", "pos": [20, 21]}}
{"token": ["The", "stimulation", "of", "absorption", "in", "response", "to", "(", "C1419815#ent", "<e1>", "Leu8)-AII", "alone", "or", "together", "with", "AII", "was", "abolished", "by", "C0733398#ent", "<e2>", "."], "h": {"id": "C1419815", "name": "C1419815#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0733398", "name": "C0733398#ent", "pos": [19, 20]}}
{"token": ["The", "C1418654#ent", "<e1>", "the", "X", "chromosome", "the", "C1418654#ent", "<e1>", "PLP", ")", "and", "DM(20", ")", ",", "two", "dominant", "integral", "membrane", "proteins", "central", "nervous", "system", "CNS", ")", "myelin", "."], "h": {"id": "C1418654", "name": "C1418654#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418654", "name": "C1418654#ent", "pos": [1, 2]}}
{"token": ["CAG", "repeats", "C0795843#ent", "<e1>", "known", "to", "link", "with", "C0751781#ent", "<e2>", ",", "was", "not", "expanded", "."], "h": {"id": "C0795843", "name": "C0795843#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751781", "name": "C0751781#ent", "pos": [8, 9]}}
{"token": ["Recent", "studies", "have", "identified", "an", "unstable", "expansion", "of", "a", "CAG", "repeat", "in", "a", "gene", "located", "on", "C0795843#ent", "<e1>", "a", "cause", "of", "dentatorubropallidoluysian", "atrophy", "C0751781#ent", "<e2>", ")", "."], "h": {"id": "C0795843", "name": "C0795843#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0751781", "name": "C0751781#ent", "pos": [23, 24]}}
{"token": ["C1881340#ent", "<e1>", ">", "rutin", ">", "quercetin", ">", "C0067067#ent", "<e2>", "in", "both", "systems", "(", "p", "<", "0.05", ")", ",", "which", "was", "negatively", "correlated", "with", "their", "partition", "coefficients"], "h": {"id": "C1881340", "name": "C1881340#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0067067", "name": "C0067067#ent", "pos": [7, 8]}}
{"token": ["Dorzolamide", "(", "C0771293#ent", "<e1>", ",", "the", "first", "C0007028#ent", "<e2>", "CA", ")", "inhibitor", "to", "become", "available", "for", "clinical", "use", "lowers", "intraocular", "pressure", "IOP", ")", "by", "reducing", "aqueous", "humour", "formation", "."], "h": {"id": "C0771293", "name": "C0771293#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007028", "name": "C0007028#ent", "pos": [7, 8]}}
{"token": ["Rat", "embryo", "cells", "REC", ")", "transformed", "by", "the", "C0018446#ent", "<e1>", "the", "cooperating", "C0080296#ent", "<e2>", "highly", "resistant", "to", "ionizing", "radiation", "compared", "with", "the", "nontransformed", "parent", "cells", ",", "REC", ",", "or", "immortalized", "REC", "."], "h": {"id": "C0018446", "name": "C0018446#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0080296", "name": "C0080296#ent", "pos": [12, 13]}}
{"token": ["We", "previously", "reported", "that", "5-LOX", "and", "C1412356#ent", "<e1>", "are", "upregulated", "in", "human", "pancreatic", "cancer", "cells", "that", "blockade", "of", "these", "C3540790#ent", "<e2>", "abolishes", "pancreatic", "cancer", "cell", "growth"], "h": {"id": "C1412356", "name": "C1412356#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [19, 20]}}
{"token": ["Perhaps", "altering", "C1539478#ent", "<e1>", "expression", "with", "recombinant", "proteins", "ameliorate", "inflammation", "in", "C0154778#ent", "<e2>", "up-regulate", "muscle", "regeneration"], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0154778", "name": "C0154778#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "determined", "if", "purified", "C1706574#ent", "<e1>", ",", "in", "the", "absence", "of", "the", "plant-derived", "C0033993#ent", "<e2>", "enzyme", "myrosinase", ",", "could", "affect", "pulmonary", "and", "hepatic", "ethoxyresorufin", "O-deethylase", "EROD", ")", "and/or", "NAD(P)H-quinone", "oxidoreductase", "1", "NQO1", ")", "activity", "."], "h": {"id": "C1706574", "name": "C1706574#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [14, 15]}}
{"token": ["C0276138#ent", "<e1>", "through", "several", "stages", ",", "including", "C0042769#ent", "<e2>", "autoimmunity", ",", "and", "dilated", "cardiomyopathy"], "h": {"id": "C0276138", "name": "C0276138#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["This", "boy", "presented", "with", "MCNS", ",", "complicated", "by", "C0022660#ent", "<e1>", "and", "subsequently", "developed", "C0342124#ent", "<e2>", "vitiligo", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0342124", "name": "C0342124#ent", "pos": [13, 14]}}
{"token": ["Lower", "total", "doses", "UVA", "or", "UVB", "may", "be", "needed", "when", "patients", "with", "C0033860#ent", "<e1>", "are", "treated", "concomitantly", "with", "C0288792#ent", "<e2>", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0288792", "name": "C0288792#ent", "pos": [18, 19]}}
{"token": ["Delivered", "C3273618#ent", "<e1>", "in", "a", "corn", "oil", "carrier", ",", "TCDD", "suppresses", "C3810569#ent", "<e2>", "activity/amount", "at", "doses", "as", "low", "as", "1", "microgram/kg", "in", "responsive", "C57BL/6J(Ahb/b", ")", "mice", "."], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [11, 12]}}
{"token": ["In", "MEN1", "patients", "with", "C0149911#ent", "<e1>", "due", "to", "increased", "secretion", "of", "parathyroid", "hormone", "the", "plasma", "levels", "C1415831#ent", "<e2>", "were", "significantly", "higher", "before", "than", "after", "surgical", "removal", "the", "parathyroid", "adenomas"], "h": {"id": "C0149911", "name": "C0149911#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415831", "name": "C1415831#ent", "pos": [16, 17]}}
{"token": ["hENT1", "(", "human", "equilibrative", "nucleoside", "transporter", "1", "is", "inhibited", "by", "nanomolar", "concentrations", "of", "various", "structurally", "distinct", "C0042402#ent", "<e1>", "including", "dipyridamole", ",", "dilazep", ",", "C0209869#ent", "<e2>", ",", "soluflazine", "and", "NBMPR", "(", "nitrobenzylmercaptopurine", "ribonucleoside", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0209869", "name": "C0209869#ent", "pos": [23, 24]}}
{"token": ["Using", "yeast", "two-hybrid", "co-immunoprecipitation", ",", "and", "GST", "pull-down", "assays", "we", "identified", "T-cell", "SH2", "adapter", "(", "C1420018#ent", "<e1>", ")", "as", "a", "protein", "that", "interacts", "with", "C1566790#ent", "<e2>", "and", "Smad3", "."], "h": {"id": "C1420018", "name": "C1420018#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [24, 25]}}
{"token": ["Specific", "C1456413#ent", "<e1>", "as", "described", "in", "paraneoplastic", "cerebellar", "degeneration", "C1824492#ent", "<e2>", ")", "were", "not", "detected", "in", "any", "of", "these", "patients", "or", "in", "control", "patients", "."], "h": {"id": "C1456413", "name": "C1456413#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1824492", "name": "C1824492#ent", "pos": [9, 10]}}
{"token": ["C3536785#ent", "<e1>", "similarly", "administered", "to", "patients", "with", "SAH", ",", "and", "C3889436#ent", "<e2>", "was", "sampled", "via", "external", "ventricular", "drains"], "h": {"id": "C3536785", "name": "C3536785#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "detectable", "levels", "of", "CCL20", "protein", "seen", "in", "the", "BAL", "fluid", "components", "of", "patients", "with", "active", "sarcoidosis", "and", "C3668957#ent", "<e1>", "AMs", "release", "the", "C1705084#ent", "<e2>", "ligand", "in", "vitro"], "h": {"id": "C3668957", "name": "C3668957#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705084", "name": "C1705084#ent", "pos": [24, 25]}}
{"token": ["Inhibition", "of", "C0074993#ent", "<e1>", "DL-threo-dihydrosphingosine", "and", "N", ",", "N-dimethylsphingosine", "did", "not", "affect", "C0031669#ent", "<e2>", "superoxide", "production", "markedly", "inhibited", "receptor-stimulated", "Ca2", "+", "mobilization", "and", "enzyme", "release", "."], "h": {"id": "C0074993", "name": "C0074993#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [12, 13]}}
{"token": ["Pulmonary", "aspergillosis", "therapy", "often", "difficult", ",", "because", "delivery", "of", "the", "C0013227#ent", "<e1>", "to", "the", "C0578491#ent", "<e2>", "limited", "and", "drug", "tolerance", "poor", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0578491", "name": "C0578491#ent", "pos": [14, 15]}}
{"token": ["The", "goal", "of", "administering", "nebulized", "antibiotics", "is", "to", "provide", "patients", "with", "a", "high", "concentration", "of", "C0013227#ent", "<e1>", "at", "the", "C0578491#ent", "<e2>", "minimal", "systemic", "effects"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0578491", "name": "C0578491#ent", "pos": [19, 20]}}
{"token": ["Pharmacokinetic", "factors", "crucial", "since", "good", "in", "vitro", "results", "can", "not", "predict", "in", "vivo", "success", "unless", "the", "C0013227#ent", "<e1>", "is", "present", "in", "effective", "concentration", "at", "the", "C0578491#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0578491", "name": "C0578491#ent", "pos": [25, 26]}}
{"token": ["Studies", "of", "respiratory", "tract", "infection", "highlighted", "the", "importance", "of", "drug", "concentrations", "the", "site", "of", "infection", "and", "have", "demonstrated", "a", "role", "for", "white", "blood", "cells", "the", "delivery", "of", "C0013227#ent", "<e1>", "to", "the", "C0578491#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0578491", "name": "C0578491#ent", "pos": [31, 32]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "clinicopathological", "characteristics", "of", "C0006271#ent", "<e1>", "in", "patients", "with", "C0003873#ent", "<e2>", "."], "h": {"id": "C0006271", "name": "C0006271#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}}
{"token": ["The", "results", "obtained", "after", "treatment", "of", "the", "fat", "body", "C1417680#ent", "<e1>", ",", "hyaluronidase", ",", "phospholipase", "C", "proteolytic", "enzymes", "that", "C0072522#ent", "<e2>", "and", "phospholipoproteins", "are", "constituents", "of", "this", "basement", "membrane"], "h": {"id": "C1417680", "name": "C1417680#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [19, 20]}}
{"token": ["Conversion", "of", "P(II)-AT", "to", "P(II)-DA", "requires", "the", "presence", "of", "UTP", ",", "ATP", ",", "and", "C1291208#ent", "<e1>", ";", "it", "is", "catalyzed", "by", "an", "C0027203#ent", "<e2>", "present", "in", "P(I", ")", "preparations", "."], "h": {"id": "C1291208", "name": "C1291208#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [22, 23]}}
{"token": ["Leucyl-glycyl-glycyltripeptidase", ",", "glycyl-glycyl-glycyltripeptidase", ",", "a", "proteosterase", ",", "C0054755#ent", "<e1>", "a", "neutrale", "proteinase", "and", "basic", "proteinase", "C1332804#ent", "<e2>", "and", "cathepsin", "C", "increased", "."], "h": {"id": "C0054755", "name": "C0054755#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [15, 16]}}
{"token": ["The", "evidence", "that", "C3853888#ent", "<e1>", "protein", "abnormalities", "breast", "cancer", "resistance", "to", "tamoxifen", "therapy", "relative", "sensitivity", "chemotherapy", "regimens", "including", "C0085752#ent", "<e2>", "is", "presented", "."], "h": {"id": "C3853888", "name": "C3853888#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "in", "situ", "reconstitution", "experiments", "showed", "that", "C0001942#ent", "<e1>", "is", "able", "to", "accept", "electrons", "from", "C0077656#ent", "<e2>", "present", "in", "Escherichia", "coli", "membranes", ",", "suggesting", "the", "ubiquinol", "oxidation", "activity", "C0001942#ent", "<e1>", "has", "a", "physiological", "function"], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0077656", "name": "C0077656#ent", "pos": [16, 17]}}
{"token": ["C0054869#ent", "<e1>", "hydrolyzing", "activity", "was", "low", "and", "not", "significantly", "affected", "by", "C0055730#ent", "<e2>", "treatment", "."], "h": {"id": "C0054869", "name": "C0054869#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0055730", "name": "C0055730#ent", "pos": [11, 12]}}
{"token": ["In", "this", "report", "we", "present", "evidence", "that", "the", "C0031727#ent", "<e1>", "encoded", "by", "the", "tumor", "progression", "locus", "2", "gene", "C1307220#ent", "<e2>", ")", "contributes", "to", "the", "activation", "of", "the", "MAPK", "cascade"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1307220", "name": "C1307220#ent", "pos": [18, 19]}}
{"token": ["Whereas", "all", "offspring", "in", "a", "C3470496#ent", "<e1>", "shared", "a", "common", "mother", ",", "each", "brood", "was", "C0037205#ent", "<e2>", "by", "2", "to", ">", "10", "males", "."], "h": {"id": "C3470496", "name": "C3470496#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037205", "name": "C0037205#ent", "pos": [15, 16]}}
{"token": ["Neurofibromin", ",", "the", "protein", "encoded", "by", "NF1", ",", "possesses", "an", "intrinsic", "C0018296#ent", "<e1>", "accelerating", "activity", "for", "the", "C0080058#ent", "<e2>"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "therapeutic", "effect", "multilayer", "amniotic", "membrane", "transplantation", "(", "AMT", ")", "in", "conjunction", "with", "C0003451#ent", "<e1>", "and", "corticosteroid", "therapy", "herpes", "necrotizing", "C0022568#ent", "<e2>"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0022568", "name": "C0022568#ent", "pos": [21, 22]}}
{"token": ["The", "results", "suggest", "that", "C0027096#ent", "<e1>", "regulated", "by", "brain", "Ca2", "+", ",", "C0006776#ent", "<e2>", "a", "similar", "but", "distinct", "mechanism", "in", "comparison", "with", "that", "of", "smooth", "muscle", "myosin"], "h": {"id": "C0027096", "name": "C0027096#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006776", "name": "C0006776#ent", "pos": [12, 13]}}
{"token": ["Gelsolin", "(", "0.01:actin", ")", "reduced", "the", "inhibition", "of", "C0027096#ent", "<e1>", "by", "caldesmon", "and", "increased", "the", "potency", "of", "C0006776#ent", "<e2>", "in", "reversing", "this", "inhibition", "."], "h": {"id": "C0027096", "name": "C0027096#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006776", "name": "C0006776#ent", "pos": [17, 18]}}
{"token": ["In", "smooth", "muscle", "Mr", "20,000", "light", "chain", "of", "C0027096#ent", "<e1>", "is", "phosphorylated", "by", "a", "C0006776#ent", "<e2>"], "h": {"id": "C0027096", "name": "C0027096#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006776", "name": "C0006776#ent", "pos": [14, 15]}}
{"token": ["The", "triple", "A", "syndrome", "caused", "by", "autosomal", "recessively", "inherited", "mutations", "in", "the", "C1422135#ent", "<e1>", "is", "characterized", "by", "achalasia", ",", "C0344505#ent", "<e2>", "and", "adrenal", "insufficiency", "well", "as", "progressive", "neurological", "impairment"], "h": {"id": "C1422135", "name": "C1422135#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0344505", "name": "C0344505#ent", "pos": [19, 20]}}
{"token": ["The", "triple", "A", "syndrome", "caused", "by", "mutations", "in", "the", "C1422135#ent", "<e1>", "which", "encodes", "a", "protein", "known", "as", "ALADIN", "(", "C0344505#ent", "<e2>", "aDrenal", "Insufficiency", "Neurologic", "disorder", "."], "h": {"id": "C1422135", "name": "C1422135#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0344505", "name": "C0344505#ent", "pos": [19, 20]}}
{"token": ["Three", "patients", "underwent", "brain", "scanning", "evaluation", "of", "C0348165#ent", "<e1>", "were", "simultaneously", "treated", "for", "C0009450#ent", "<e2>", "to", "the", "central", "nervous", "process", "."], "h": {"id": "C0348165", "name": "C0348165#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "Dermatophagoides", "pteronyssinus", "first", "increase", "cAMP", "in", "atopic", "dermatitis", "T", "cells", "activating", "adenylate", "cyclase", "phospholipase", "C", "and", "next", "decrease", "cAMP", "by", "activating", "C0056696#ent", "<e1>", "protein", "kinase", "A", "which", "may", "be", "activated", "by", "C1382029#ent", "<e2>", "cAMP", "signal", "."], "h": {"id": "C0056696", "name": "C0056696#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [35, 36]}}
{"token": ["Reduction", "of", "iron", "(", "III", ")", "outside", "the", "cell", "is", "accomplished", "by", "means", "of", "C0028123#ent", "<e1>", "encoded", "by", "FRE1", "and", "C1710520#ent", "<e2>", ",", "homologues", "of", "the", "gp91-phox", "component", "the", "oxygen", "reductase", "human", "granulocytes", "."], "h": {"id": "C0028123", "name": "C0028123#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1710520", "name": "C1710520#ent", "pos": [20, 21]}}
{"token": ["We", "related", "attendance", "following", "CABG", "to", "severity", "of", "C1457887#ent", "<e1>", "general", "health", "status", "Short", "Form-36", ")", "and", "prevalence", "of", "modifiable", "coronary", "artery", "disease", "C0010068#ent", "<e2>", ")", "risk", "factors"], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [23, 24]}}
{"token": ["Concern", "falls", "into", "five", "categories", ":", "recoarctation", ",", "endocarditis", ",", "stenotic", "and/or", "incompetent", "coexisting", "bicuspid", "aortic", "valve", "C0003486#ent", "<e1>", "formation", "and", "C0020538#ent", "<e2>"], "h": {"id": "C0003486", "name": "C0003486#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [21, 22]}}
{"token": ["Dominant", "deafness", "defined", "by", "DFNA38", "is", "more", "severe", "than", "deafness", "of", "C0043207#ent", "<e1>", "patients", "and", "lacks", "any", "C0039082#ent", "<e2>", "features", "."], "h": {"id": "C0043207", "name": "C0043207#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "sought", "to", "define", "the", "role", "of", "ICHTN", "in", "mediating", "C0020538#ent", "<e1>", "HTN", ")", "during", "CO(2)", "pneumoperitoneum", "C1417772#ent", "<e2>", ")", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417772", "name": "C1417772#ent", "pos": [18, 19]}}
{"token": ["Ectopic", "Smac/DIABLO", "alone", "inhibited", "cell", "growth", "arrested", "cells", "G0/G1", "phase", ",", "and", "sensitized", "C0206526#ent", "<e1>", "EOC", "cells", "to", "C1336646#ent", "<e2>", "or", "paclitaxel-induced", "apoptosis", "."], "h": {"id": "C0206526", "name": "C0206526#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1336646", "name": "C1336646#ent", "pos": [18, 19]}}
{"token": ["The", "C1257966#ent", "<e1>", "silymarine", "extract", "consist", "of", "C0074546#ent", "<e2>", ",", "silydianin", ",", "silybin", "(", "A", "and", "B", ")", "and", "isosilybin", "(", "A", "and", "B", ")", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0074546", "name": "C0074546#ent", "pos": [7, 8]}}
{"token": ["A", "range", "of", "substituted", "benzenes", "phenols", ",", "benzaldehydes", ",", "and", "C0053225#ent", "<e1>", "shown", "to", "bind", "to", "the", "four", "P450", "C3541394#ent", "<e2>", "."], "h": {"id": "C0053225", "name": "C0053225#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "C0388419#ent", "<e1>", "to", "be", "a", "useful", "tool", "for", "studying", "neuronal", "nicotinic", "receptors", "the", "C2698300#ent", "<e2>"], "h": {"id": "C0388419", "name": "C0388419#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2698300", "name": "C2698300#ent", "pos": [15, 16]}}
{"token": ["This", "study", "was", "aimed", "at", "assessing", "coronary", "reperfusion", "patients", "with", "acute", "myocardial", "infarction", "C0340293#ent", "<e1>", ")", "undergoing", "systemic", "thrombolysis", "SK", "and", "C1705133#ent", "<e2>", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705133", "name": "C1705133#ent", "pos": [21, 22]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "the", "ability", "of", "C1332802#ent", "<e1>", "activate", "HIV", "type", "1", "HIV-1", ")", "replication", "in", "naturally", "infected", "C0206744#ent", "<e2>", "alone", "or", "in", "combination", "with", "immobilized", "anti-CD3", "monoclonal", "antibody"], "h": {"id": "C1332802", "name": "C1332802#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0206744", "name": "C0206744#ent", "pos": [24, 25]}}
{"token": ["On", "the", "other", "hand", ",", "C0034283#ent", "<e1>", "alone", "at", "the", "recommended", "dose", "to", "suppress", "C0024535#ent", "<e2>", "malaria", "in", "some", "children", "of", "another", "group", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "effectiveness", "and", "safety", "of", "the", "combination", "of", "artesunate", ",", "sulphadoxine", "+", "C0034283#ent", "<e1>", "and", "primaquine", "in", "the", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [21, 22]}}
{"token": ["Quinine", "for", "3", "days", "along", "with", "tetracycline", "and", "sulfadoxine", "-", "C0034283#ent", "<e1>", "achieved", "a", "100", "per", "cent", "cure", "rate", "uncomplicated", "chloroquine", "resistant", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [22, 23]}}
{"token": ["A", "52-year-old", "man", "on", "haemodialysis", "treatment", "for", "C0017662#ent", "<e1>", "had", "a", "nephrotic", "syndrome", "C0020445#ent", "<e2>", ",", "severe", "arterial", "hypertension", "peripheral", "vascular", "disease", "stage", "IIb"], "h": {"id": "C0017662", "name": "C0017662#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [13, 14]}}
{"token": ["Increasing", "the", "concentration", "of", "volatile", "anesthetic", "less", "effect", "on", "a", "neuromuscular", "blockade", "by", "C0042435#ent", "<e1>", "than", "on", "one", "produced", "by", "other", "C0027867#ent", "<e2>", "e.g.", ",", "pancuronium", "and", "d-tubucurarine", ")", "."], "h": {"id": "C0042435", "name": "C0042435#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [21, 22]}}
{"token": ["Recessive", "mutations", "in", "C1412367#ent", "<e1>", ",", "a", "guanine-nucleotide", "exchange", "factor", "the", "C0242853#ent", "<e2>", "Rab5", "and", "Rac1", ",", "cause", "juvenile", "amyotrophic", "lateral", "sclerosis", "ALS2", ")", "and", "related", "motoneuron", "disorders"], "h": {"id": "C1412367", "name": "C1412367#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [11, 12]}}
{"token": ["C0015469#ent", "<e1>", "subperiosteal", "abscess", "and", "C0022890#ent", "<e2>", "were", "the", "common", "complications", "among", "the", "EC", "group", ",", "while", "meningitis", "and", "brain", "abscess", "common", "in", "the", "IC", "group", "."], "h": {"id": "C0015469", "name": "C0015469#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022890", "name": "C0022890#ent", "pos": [5, 6]}}
{"token": ["Vestibular", "dysfunction", "C0015469#ent", "<e1>", "considered", "to", "be", "due", "to", "a", "C0022890#ent", "<e2>", "as", "vestibular", "neuronitis", "acoustic", "neuromas"], "h": {"id": "C0015469", "name": "C0015469#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022890", "name": "C0022890#ent", "pos": [10, 11]}}
{"token": ["While", "little", "change", "was", "evident", "for", "C0251211#ent", "<e1>", "PEPCK", ")", "expression", ",", "C1418609#ent", "<e2>", "expression", "was", "decreased", "16-fold", "in", "fasted", "PPARalpha", "null", "mice", "compared", "with", "the", "wild-type", "control", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418609", "name": "C1418609#ent", "pos": [12, 13]}}
{"token": ["A", "metal", "ion", "dependent", "stereoselectivity", "of", "inhibition", "was", "measured", "for", "these", "analogues", "with", "the", "C0251211#ent", "<e1>", "enolase", ",", "and", "C1418609#ent", "<e2>"], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418609", "name": "C1418609#ent", "pos": [19, 20]}}
{"token": ["C0251211#ent", "<e1>", "PEPCKase", ")", "and", "C1418609#ent", "<e2>", "PKase", ")", "were", "measured", "in", "Saccharomyces", "cerevisiae", "grown", "in", "the", "presence", "of", "glycolytic", "and", "gluconeogenic", "carbon", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418609", "name": "C1418609#ent", "pos": [5, 6]}}
{"token": ["As", "anticipated", ",", "C0002962#ent", "<e1>", "CBF", "increases", "in", "the", "C0752262#ent", "<e2>"], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752262", "name": "C0752262#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "C3538682#ent", "<e1>", "siRNA", "down-regulates", "C3538682#ent", "<e1>", "expression", ",", "and", "neither", "mPGES-2", "nor", "C1846861#ent", "<e1>", "substituted", "for", "C3538682#ent", "<e1>", "in", "a", "knockdown", "setting", "in", "gingival", "fibroblasts"], "h": {"id": "C1846861", "name": "C1846861#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3538682", "name": "C3538682#ent", "pos": [3, 4]}}
{"token": ["Neither", "mPGES-2", "nor", "C1846861#ent", "<e1>", "expression", "was", "affected", "by", "siRNA", "silencing", "of", "C3538682#ent", "<e2>", "."], "h": {"id": "C1846861", "name": "C1846861#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538682", "name": "C3538682#ent", "pos": [12, 13]}}
{"token": ["Mice", "lacking", "C1422519#ent", "<e1>", "die", "soon", "after", "birth", "because", "of", "C0022660#ent", "<e2>"], "h": {"id": "C1422519", "name": "C1422519#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [10, 11]}}
{"token": ["C1334117#ent", "<e1>", "been", "used", "in", "prophylaxis", "and", "treatment", "of", "neutropenic", "C0015967#ent", "<e2>", "episodes", "."], "h": {"id": "C1334117", "name": "C1334117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [10, 11]}}
{"token": ["By", "binding", "32P-labeled", "MAPs", "to", "neurofilament", "proteins", "which", "were", "transferred", "electrophoretically", "to", "C0600190#ent", "<e1>", ",", "we", "determined", "that", ",", "of", "the", "three", "C1826396#ent", "<e2>", "only", "the", "core", "NF70", "subunit", "bound", "MAPs", "."], "h": {"id": "C0600190", "name": "C0600190#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1826396", "name": "C1826396#ent", "pos": [22, 23]}}
{"token": ["Altogether", "more", "than", "50,000", "subjects", "have", "volunteered", "for", "studies", "on", "the", "effect", "of", "C0007804#ent", "<e1>", "in", "the", "primary", "or", "secondary", "prevention", "myocardial", "infarction", "C0948008#ent", "<e2>"], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0948008", "name": "C0948008#ent", "pos": [23, 24]}}
{"token": ["The", "presence", "of", "C1514550#ent", "<e1>", "PKA", ")", "in", "the", "plasma", "membrane", "compartment", "its", "association", "with", "an", "C1412314#ent", "<e2>", "AKAP150", ")", "is", "implicated", "in", "mediating", "cAMP", "regulatory", "events", "in", "the", "rat", "myometrium", "."], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412314", "name": "C1412314#ent", "pos": [16, 17]}}
{"token": ["Consensus", "primers", "the", "polymerase", "chain", "reaction", "designed", "based", "on", "conserved", "motifs", "within", "the", "C0036734#ent", "<e1>", "RNA", "helicase", "domains", "encoded", "by", "the", "NS", "3", "genes", "of", "C0011311#ent", "<e2>", "and", "other", "flaviviruses", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011311", "name": "C0011311#ent", "pos": [25, 26]}}
{"token": ["We", "investigated", "the", "effect", "of", "dietary", "combination", "C1257880#ent", "<e1>", "CLA", ")", "and", "C0556150#ent", "<e2>", "DHA", ")", "to", "attenuate", "CLA-induced", "fatty", "liver", "in", "C57BL/6N", "mice"], "h": {"id": "C1257880", "name": "C1257880#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0556150", "name": "C0556150#ent", "pos": [12, 13]}}
{"token": ["As", "C0037567#ent", "<e1>", "is", "a", "drug", "with", "C0242898#ent", "<e2>", "properties", ",", "a", "GABA", "involvement", "in", "the", "pathogenesis", "of", "schizophrenia", "is", "discussed", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [7, 8]}}
{"token": ["Two", "patients", "had", "C0221406#ent", "<e1>", "while", "the", "other", "two", "had", "C1864846#ent", "<e2>"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1864846", "name": "C1864846#ent", "pos": [10, 11]}}
{"token": ["The", "treatment", "of", "choice", "of", "C0221406#ent", "<e1>", "transsphenoidal", "resection", "the", "microadenoma", "while", "in", "C1864846#ent", "<e2>", "bilateral", "adrenalectomy", "subsequent", "steroid", "replacement", "recommended", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1864846", "name": "C1864846#ent", "pos": [13, 14]}}
{"token": ["The", "severe", "C1175175#ent", "<e1>", "SARS", ")", "caused", "a", "large", "outbreak", "of", "atypical", "C1535939#ent", "<e2>", "in", "Beijing", ",", "China", "from", "early", "March", "2003", "."], "h": {"id": "C1175175", "name": "C1175175#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [12, 13]}}
{"token": ["Severe", "acute", "respiratory", "distress", "syndrome", "SARS", ")", "caused", "by", "C1175175#ent", "<e1>", "SARS-CoV", ")", "is", "a", "systemic", "infection", "clinically", "manifests", "as", "progressive", "C1535939#ent", "<e2>", "."], "h": {"id": "C1175175", "name": "C1175175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [21, 22]}}
{"token": ["This", "meso-endodermal", "phenotype", "was", "C1516876#ent", "<e1>", "regulated", "through", "cytokine", "signaling", "including", "transforming", "growth", "factor", "beta", "C0377148#ent", "<e2>", "fibroblast", "growth", "factor", "other", "signaling", "pathways"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [15, 16]}}
{"token": ["We", "did", "a", "retrospective", "study", "all", "acute", "lymphoblastic", "leukaemia", "C0812385#ent", "<e1>", ")", "patients", "on", "United", "Kingdom", "ALL", "protocol", "were", "admitted", "for", "febrile", "C0027947#ent", "<e2>", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [22, 23]}}
{"token": ["We", "conclude", "that", "G-CSF", "can", "be", "safely", "administered", "as", "an", "adjunct", "to", "induction", "therapy", "C0812385#ent", "<e1>", "and", "is", "clinically", "beneficial", "by", "ameliorating", "C0027947#ent", "<e2>", "and", "reducing", "infectious", "complications"], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [22, 23]}}
{"token": ["Finally", ",", "the", "orf", "virus", "GM-CSF", "inhibitory", "factor", "gene", "GIF", ")", "at", "the", "right", "terminus", "of", "the", "C0042720#ent", "<e1>", "an", "inhibitor", "of", "GM-CSF", "that", "also", "binds", "C0879590#ent", "<e2>", "."], "h": {"id": "C0042720", "name": "C0042720#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [26, 27]}}
{"token": ["Finally", ",", "the", "serum", "concentrations", "of", "the", "liver", "enzymes", "glutamic-oxaloacetic", "transaminase", "SGOT", ")", "and", "C3887708#ent", "<e1>", "SGPT", ")", "were", "measured", "24", "h", "following", "placebo", "or", "C2343921#ent", "<e2>", "administration", "."], "h": {"id": "C3887708", "name": "C3887708#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2343921", "name": "C2343921#ent", "pos": [25, 26]}}
{"token": ["The", "other", "four", "enzymes", ",", "M-form", "(", "C0911506#ent", "<e1>", ")", "PST", ",", "SULT1B2", "ST", ",", "C1420519#ent", "<e2>", "ST", "and", "SULT1E", "ST", "showed", "intermediate", "levels", "activity", "toward", "some", "of", "these", "compounds", "."], "h": {"id": "C0911506", "name": "C0911506#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420519", "name": "C1420519#ent", "pos": [15, 16]}}
{"token": ["We", "encountered", "a", "53-year-old", "male", "patient", "with", "C0085270#ent", "<e1>", "chronic", "paranasal", "sinusitis", "fibrous", "nodules", "the", "lungs", ",", "intracranial", "pachymeningitis", ",", "and", "C0242343#ent", "<e2>", "with", "central", "diabetes", "insipidus", "DI", ")", "as", "a", "possible", "manifestation", "of", "multifocal", "fibrosclerosis"], "h": {"id": "C0085270", "name": "C0085270#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242343", "name": "C0242343#ent", "pos": [21, 22]}}
{"token": ["Of", "the", "47", "patients", "with", "C0023896#ent", "<e1>", "40", "were", "homozygous", "for", "the", "C0001985#ent", "<e2>", "the", "remaining", "seven", "cases", "were", "heterozygous", "for", "the", "normal", "and", "mutant", "aldehyde", "dehydrogenase-2", "genes"], "h": {"id": "C0023896", "name": "C0023896#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001985", "name": "C0001985#ent", "pos": [12, 13]}}
{"token": ["In", "C0023896#ent", "<e1>", "patients", ",", "the", "unusual", "type", "of", "C0001985#ent", "<e2>", "activity", "observed", "was", "not", "different", "from", "the", "unusual", "type", "observed", "in", "nonhepatobiliary", "disease", "patients", "."], "h": {"id": "C0023896", "name": "C0023896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001985", "name": "C0001985#ent", "pos": [9, 10]}}
{"token": ["The", "case", "is", "reported", "of", "a", "41", "year", "old", "white", "woman", "who", "developed", "systemic", "lupus", "erythematosus", "SLE", ")", "seven", "years", "after", "C1527336#ent", "<e1>", "four", "years", "after", "the", "association", "of", "C1527336#ent", "<e1>", "Jaccoud's", "arthritis"], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [21, 22]}}
{"token": ["A", "study", "of", "the", "phenotype", ",", "activation", "and", "adhesive", "cells", "factors", "and", "cytokines", "in", "minor", "salivary", "glands", "patients", "with", "primary", "Sj\u00f6gren's", "syndrome", "pSS", ")", ",", "C1527336#ent", "<e1>", "sSS", ")", "and", "autoimmune", "diseases", "AD", ")", "without", "C1527336#ent", "<e1>"], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [25, 26]}}
{"token": ["Patients", "with", "secondary", "C1527336#ent", "<e1>", "lower", "cytotoxicity", "compared", "with", "those", "who", "had", "C1527336#ent", "<e1>", "28.5", "+", "/-", "5.5", "%", "versus", "37.3", "+", "/-", "4.2", "%", ",", "P", "less", "than", "0.01", ")", "."], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [3, 4]}}
{"token": ["We", "investigated", "the", "pharmacokinetics", ",", "efficacy", ",", "and", "tolerability", "of", "a", "once-daily", "regimen", "of", "C1321660#ent", "<e1>", ",", "tenofovir", ",", "emtricitabine", "and", "C0939237#ent", "<e2>", "in", "HIV-infected", "treatment-naive", "subjects", "."], "h": {"id": "C1321660", "name": "C1321660#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0939237", "name": "C0939237#ent", "pos": [21, 22]}}
{"token": ["C1321660#ent", "<e1>", "(", "FPV", ")", "with", "and", "without", "C0939237#ent", "<e2>", "(", "RTV", ")", "was", "added", "to", "the", "antiretroviral", "regimens", "human", "immunodeficiency", "virus-infected", "subjects", "receiving", "nevirapine", "(", "NVP", ")", "to", "evaluate", "this", "drug", "interaction"], "h": {"id": "C1321660", "name": "C1321660#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0939237", "name": "C0939237#ent", "pos": [8, 9]}}
{"token": ["Fifty-three", "patients", "with", "C0002726#ent", "<e1>", "between", "1976", "and", "1983", "were", "treated", "with", "C0009262#ent", "<e2>", ",", "and", "their", "clinical", "course", "survival", "were", "compared", "with", "that", "in", "29", "other", "patients", "seen", "between", "1961", "and", "1973", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [12, 13]}}
{"token": ["Prognosis", ",", "which", "depends", "on", "the", "occurrence", "of", "C0002726#ent", "<e1>", ",", "has", "been", "transformed", "by", "C0009262#ent", "<e2>", "treatment", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [15, 16]}}
{"token": ["C0035064#ent", "<e1>", "included", "amantadine", ",", "amphetamine", ",", "bromocriptine", ",", "bupropion", ",", "C0025810#ent", "<e2>", ",", "and", "selegiline", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025810", "name": "C0025810#ent", "pos": [11, 12]}}
{"token": ["Using", "C3494348#ent", "<e1>", "dominant", "negative", "constructs", ",", "we", "show", "that", "CO", "enhances", "C1367307#ent", "<e2>", "activation", "via", "phosphatidylinositol", "3-kinase/Akt", "and", "p38", "MAPK", "pathways", "subsequent", "attenuation", "of", "Fas", "expression", "and", "caspase", "3", "activity"], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [12, 13]}}
{"token": ["This", "study", "was", "designed", "to", "evaluate", "the", "effect", "of", "severe", "peripheral", "arterial", "insufficiency", "carnitine", "concentrations", "and", "C1413700#ent", "<e1>", "palmitoyltransferase", "activities", "the", "ischemic", "skeletal", "muscles", "patients", "with", "severe", "C0085096#ent", "<e2>"], "h": {"id": "C1413700", "name": "C1413700#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [27, 28]}}
{"token": ["7", ")", "We", "conclude", "that", "C0063041#ent", "<e1>", "should", "not", "be", "used", "to", "treat", "C0035435#ent", "<e2>"], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesize", "that", "C0011882#ent", "<e1>", "nephropathies", "and", "retinopathies", "develop", "in", "part", "by", "exclusion", "of", "C2348308#ent", "<e2>", "uptake", "by", "GLUT", "transporters", "when", "blood", "glucose", "levels", "above", "normal", "."], "h": {"id": "C0011882", "name": "C0011882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2348308", "name": "C2348308#ent", "pos": [14, 15]}}
{"token": ["Over", "the", "last", "5", "years", ",", "a", "tremendous", "effort", "has", "gone", "to", "identify", "the", "major", "intracellular", "regulators", "of", "C0031670#ent", "<e1>", "to", "the", "cloning", "of", "two", "mammalian", "phospholipase", "D", "enzymes", "phospholipase", "D1", "C1415944#ent", "<e2>", ")", "."], "h": {"id": "C0031670", "name": "C0031670#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1415944", "name": "C1415944#ent", "pos": [31, 32]}}
{"token": ["We", "examined", "potential", "functional", "sites", "for", "interactions", "between", "SP", "and", "C1417965#ent", "<e1>", "with", "dual", "electron", "microscopic", "localization", "of", "the", "SP", "receptor", "C1424685#ent", "<e2>", ")", "and", "C1417965#ent", "<e1>", "in", "rat", "trigeminal", "dorsal", "horn"], "h": {"id": "C1417965", "name": "C1417965#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1424685", "name": "C1424685#ent", "pos": [21, 22]}}
{"token": ["C1428895#ent", "<e1>", "is", "a", "highly", "conserved", "substrate", "specific", "C0950398#ent", "<e2>", "."], "h": {"id": "C1428895", "name": "C1428895#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [8, 9]}}
{"token": ["Yeast", "and", "human", "Eme1", "protein", "in", "complex", "with", "C1428895#ent", "<e1>", ",", "constitute", "an", "C0950398#ent", "<e2>", "that", "cleaves", "branched", "DNA", "structures", "especially", "those", "arising", "during", "stalled", "DNA", "replication"], "h": {"id": "C1428895", "name": "C1428895#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [13, 14]}}
{"token": ["The", "apparent", "Km", "of", "C3539567#ent", "<e1>", "transport", "via", "C1705603#ent", "<e2>", "and", "GLUT3", "was", "1.1", "+", "/-", "0.2", "and", "1.7", "+", "/-", "0.3", "mM", ",", "respectively", "."], "h": {"id": "C3539567", "name": "C3539567#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705603", "name": "C1705603#ent", "pos": [8, 9]}}
{"token": ["Using", "the", "Xenopus", "laevis", "oocyte", "expression", "system", "examined", "transport", "of", "C3539567#ent", "<e1>", "and", "AA", "via", "glucose", "transporter", "isoforms", "C1705603#ent", "<e2>", "-", "5", "and", "SGLT1", "."], "h": {"id": "C3539567", "name": "C3539567#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705603", "name": "C1705603#ent", "pos": [18, 19]}}
{"token": ["Recently", ",", "we", "isolated", "a", "new", "complementary", "DNA", "cDNA", ")", "encoding", "human", "C1420131#ent", "<e1>", "organic", "anion", "transporter", "LST-1", ")", ",", "representing", "the", "multispecificity", "of", "human", "C0023899#ent", "<e2>", "."], "h": {"id": "C1420131", "name": "C1420131#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [25, 26]}}
{"token": ["Northern", "blot", "analysis", "that", "C1420131#ent", "<e1>", "mRNA", "is", "expressed", "exclusively", "in", "C0023899#ent", "<e2>", "."], "h": {"id": "C1420131", "name": "C1420131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}}
{"token": ["In", "summary", ",", "mast", "cell", "interactions", "in", "the", "nervous", "system", "relevant", "to", "both", "physiological", "processes", "i.e.", "reproduction", ")", "and", "pathologic", "states", "i.e.", "inflammatory", "demyelination", "C0030193#ent", "<e1>", "toxic", "and", "C0025517#ent", "<e2>", "and", "tumor", "angiogenesis", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [28, 29]}}
{"token": ["This", "paper", "is", "a", "retrospective", "review", "210", "patients", "operated", "with", "arthrotomy/arthroplasty", "for", "C0030193#ent", "<e1>", "and", "dysfunctional", "TM", "joint", "C0025517#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [18, 19]}}
{"token": ["Importantly", ",", "engagement", "of", "integrin", "alpha", "v", "beta", "5", "cell", "attachment", "C1336937#ent", "<e1>", "led", "to", "a", "redistribution", "of", "C1423944#ent", "<e2>", "from", "the", "cytosol", "to", "dynamic", "lamellipodial", "structures", "where", "C1423944#ent", "<e2>", "colocalized", "with", "integrin", "alpha", "v", "beta", "5"], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1423944", "name": "C1423944#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "C0033141#ent", "<e1>", "ventricular", "cells", "intrinsically", "predisposed", "to", "C1413603#ent", "<e2>", "and", "SD", "."], "h": {"id": "C0033141", "name": "C0033141#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413603", "name": "C1413603#ent", "pos": [10, 11]}}
{"token": ["AMPK", "phosphorylated", "the", "catalytic", "domain", "C0139905#ent", "<e1>", ",", "expressed", "in", "Escherichia", "coli", "a", "soluble", "C1428159#ent", "<e2>", "fusion", "protein", "to", "generate", "a", "single", "tryptic", "[32P]phosphopeptide", "containing", "exclusively", "phospho-Ser621", "."], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1428159", "name": "C1428159#ent", "pos": [14, 15]}}
{"token": ["One", "of", "the", "BMP", "extracellular", "antagonists", ",", "C1539614#ent", "<e1>", ",", "is", "a", "highly", "conserved", "20.7-kDa", "C0072522#ent", "<e2>", "."], "h": {"id": "C1539614", "name": "C1539614#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [15, 16]}}
{"token": ["C1417659#ent", "<e1>", "family", "interacting", "protein-1", "(", "C1425008#ent", "<e2>", ")", "is", "a", "protein", "whose", "only", "known", "function", "is", "that", "it", "binds", "C1417659#ent", "<e1>", ",", "a", "HECT-type", "E3", "ubiquitin", "ligase"], "h": {"id": "C1417659", "name": "C1417659#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1425008", "name": "C1425008#ent", "pos": [6, 7]}}
{"token": ["It", "is", "suggested", "that", "the", "inhibitory", "effect", "of", "Buddlejae", "Flos", "C1412322#ent", "<e1>", "partially", "attributable", "to", "these", "C0060444#ent", "<e2>", "or", "their", "glycosides", "."], "h": {"id": "C1412322", "name": "C1412322#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0060444", "name": "C0060444#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "we", "examined", "TGFbeta", "receptor-dependent", "phosphorylation", "of", "endoglin", "by", "the", "constitutively", "active", "forms", "the", "TGFbeta", "type", "I", "receptors", "ALK1", ",", "C1336624#ent", "<e1>", ",", "and", "the", "TGFbeta", "type", "II", "receptor", "C1420610#ent", "<e2>", "."], "h": {"id": "C1336624", "name": "C1336624#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [30, 31]}}
{"token": ["Finally", "mutation", "Y18F", ",", "but", "not", "mutation", "Y26F", ",", "abolished", "nic-cleavage", "of", "a", "supercoiled", "DNA", "the", "C0602450#ent", "<e1>", "origin", "of", "transfer", "(", "C0292818#ent", "<e2>", ")", "."], "h": {"id": "C0602450", "name": "C0602450#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0292818", "name": "C0292818#ent", "pos": [22, 23]}}
{"token": ["With", "in", "vitro", "assay", "and", "Far-Western", "analysis", "we", "demonstrated", "that", "RMP", "could", "bind", "with", "bacterially", "expressed", "recombinant", "C1705410#ent", "<e1>", "and", "RAP74", "of", "C1333721#ent", "<e2>"], "h": {"id": "C1705410", "name": "C1705410#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333721", "name": "C1333721#ent", "pos": [22, 23]}}
{"token": ["Both", "C0012634#ent", "<e1>", "had", "severe", "courses", "requiring", "chronic", "treatment", "danazol", "and", "C0036078#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "C1533126#ent", "<e1>", "did", "not", "accentuate", "the", "negative", "effects", "of", "C0001975#ent", "<e2>", "."], "h": {"id": "C1533126", "name": "C1533126#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [12, 13]}}
{"token": ["Deleting", "a", "Ser/Thr", "motif", "at", "the", "C1705504#ent", "<e1>", "of", "the", "intracellular", "tail", "of", "C1413191#ent", "<e2>", "resulted", "in", "an", "impaired", "chemokine-mediated", "activation", "of", "Erk1/2", "kinases"], "h": {"id": "C1705504", "name": "C1705504#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413191", "name": "C1413191#ent", "pos": [13, 14]}}
{"token": ["Von", "Willebrand", "factor", "C1336938#ent", "<e1>", ")", "is", "synthesized", "in", "endothelial", "cells", "pre-provWF", "and", "processed", "intracellularly", "to", "C1709708#ent", "<e2>", "(", "vWFpp", ")", "and", "mature", "C1336938#ent", "<e1>", "."], "h": {"id": "C1709708", "name": "C1709708#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [3, 4]}}
{"token": ["Electron", "microscopic", "analysis", "that", "C1333676#ent", "<e1>", "distributes", "to", "the", "region", "of", "postsynaptic", "density", "C1418984#ent", "<e2>", ")", "as", "well", "as", "presynaptic", "active", "zones", "."], "h": {"id": "C1333676", "name": "C1333676#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418984", "name": "C1418984#ent", "pos": [13, 14]}}
{"token": ["C1333676#ent", "<e1>", "is", "enriched", "in", "C1418984#ent", "<e2>", "fractions", "and", "forms", "a", "complex", "with", "liprin-alpha", ",", "GRIP", ",", "and", "AMPA", "receptors", "brain", "."], "h": {"id": "C1333676", "name": "C1333676#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418984", "name": "C1418984#ent", "pos": [5, 6]}}
{"token": ["We", "have", "investigated", "mitochondrial", "import", "processing", "of", "the", "precursor", "for", "human", "ornithine", "transcarbamylase", "C1418193#ent", "<e1>", ";", "carbamoylphosphate", ":", "L-ornithine", "carbamoyltransferase", "C3887649#ent", "<e2>", "in", "HeLa", "cells", "transformed", "with", "cDNA", "sequences", "C1418193#ent", "<e1>", "precursors", "carrying", "mutations", "in", "their", "leader", "peptides"], "h": {"id": "C3887649", "name": "C3887649#ent", "pos": [20, 21]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418193", "name": "C1418193#ent", "pos": [13, 14]}}
{"token": ["A", "50-year-old", "black", "man", "steroid-dependent", "stage", "IV", "sarcoidosis", "and", "a", "prior", "seizure", "attributed", "to", "C0393485#ent", "<e1>", "had", "progressive", "disorientation", ",", "ataxia", ",", "cranial", "neuropathies", "and", "increased", "C0013404#ent", "<e2>", "."], "h": {"id": "C0393485", "name": "C0393485#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [26, 27]}}
{"token": ["An", "important", "example", "is", "the", "replacement", "of", "a", "single", "(", "hydrophobic", ")", "valine", "by", "(", "charged", ")", "glutamate", "in", "the", "C0242853#ent", "<e1>", "Neu", ",", "and", "in", "the", "homologous", "human", "protein", "C0242957#ent", "<e2>", "."], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [30, 31]}}
{"token": ["C0037533#ent", "<e1>", "SNP", ")", ",", "a", "direct", "C1422492#ent", "<e2>", "of", "guanylate", "cyclase", "vasodilator", ",", "was", "used", "to", "enhance", "cGMP", "levels", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [7, 8]}}
{"token": ["The", "amplitudes", "of", "chemically", "evoked", "contractions", "in", "\"", "skinned", "muscle", "cells", "of", "Helix", "PRM", "Lumbricus", "segments", "were", "influenced", "neither", "by", "C0008288#ent", "<e1>", "nor", "by", "C0076113#ent", "<e2>", "."], "h": {"id": "C0008288", "name": "C0008288#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0076113", "name": "C0076113#ent", "pos": [24, 25]}}
{"token": ["Western", "analysis", "C0086376#ent", "<e1>", "in", "membrane", "fractions", "separation", "by", "free-flow", "electrophoresis", "showed", "that", "C1334101#ent", "<e2>", "was", "present", "in", "most", "fractions", ",", "whereas", "p33", "appeared", "mainly", "in", "plasmalemma-enriched", "fractions", "after", "the", "mechanical", "stimulation"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334101", "name": "C1334101#ent", "pos": [13, 14]}}
{"token": ["In", "a", "competition", "experiment", "the", "specific", "binding", "of", "[3H]phencyclidine", "was", "not", "inhibited", "by", "carbachol", ",", "muscarine", ",", "C0041345#ent", "<e1>", ",", "hexamethonium", ",", "tetrodotoxin", ",", "veratridine", "and", "C0885164#ent", "<e2>"], "h": {"id": "C0041345", "name": "C0041345#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0885164", "name": "C0885164#ent", "pos": [26, 27]}}
{"token": ["Patients", "with", "chronic", "hepatic", "encephalopathy", "C1418983#ent", "<e1>", ")", "may", "present", "C0001726#ent", "<e2>", "antidepressant", "drug", "treatment", "this", "condition", "is", "not", "uncommon", "."], "h": {"id": "C1418983", "name": "C1418983#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001726", "name": "C0001726#ent", "pos": [10, 11]}}
{"token": ["Latent", "or", "manifest", "chronic", "hepatic", "encephalopathy", "C1418983#ent", "<e1>", ")", "symptomatology", "often", "includes", "C0001726#ent", "<e2>"], "h": {"id": "C1418983", "name": "C1418983#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001726", "name": "C0001726#ent", "pos": [12, 13]}}
{"token": ["While", "U.", "maydis", "wild-type", "cells", "were", "resistant", "to", "the", "DHODH", "inhibitor", "C0877869#ent", "<e1>", ",", "strains", "expressing", "the", "human", "C3887697#ent", "<e2>", "sensitive", "to", "this", "cytostatic", "drug"], "h": {"id": "C0877869", "name": "C0877869#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887697", "name": "C3887697#ent", "pos": [18, 19]}}
{"token": ["Only", "the", "dianisidine", "derivative", "redoxal", ",", "and", "the", "biphenyl", "quinoline-carboxylic", "acid", "derivative", ",", "C0877869#ent", "<e1>", "which", "are", "known", "to", "be", "potent", "inhibitors", "of", "mammalian", "C3887697#ent", "<e2>", ",", "markedly", "reduced", "C.", "albicans", "C3887697#ent", "<e2>", "activity", "."], "h": {"id": "C0877869", "name": "C0877869#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3887697", "name": "C3887697#ent", "pos": [24, 25]}}
{"token": ["Overexpression", "of", "C0145620#ent", "<e1>", "both", "CHO-S", "and", "HEK293", "cells", "sufficient", "to", "reduce", "C1334435#ent", "<e2>", "activation", "triggered", "by", "a", "specific", "GPCR", "agonist", "."], "h": {"id": "C0145620", "name": "C0145620#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334435", "name": "C1334435#ent", "pos": [12, 13]}}
{"token": ["The", "purpose", "was", "to", "examine", "the", "reliability", "of", "measurement", "techniques", "evaluate", "the", "effect", "of", "a", "treatment", "protocol", "C0020488#ent", "<e1>", "patients", "with", "C0150055#ent", "<e2>", "the", "Achilles", "tendon"], "h": {"id": "C0020488", "name": "C0020488#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0150055", "name": "C0150055#ent", "pos": [21, 22]}}
{"token": ["Activated", "microglia", "by", "neuronal", "injury", "inflammatory", "stimulation", "nitric", "oxide", "NO", ")", "by", "inducible", "nitric", "oxide", "synthase", "iNOS", ")", "and", "reactive", "oxygen", "species", "C0812281#ent", "<e1>", ")", "such", "as", "superoxide", "anion", "resulting", "in", "C0751870#ent", "<e2>"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [31, 32]}}
{"token": ["The", "most", "effective", "medications", "are", "antihypertensives", ",", "C0935929#ent", "<e1>", ",", "statins", "and", "C0016018#ent", "<e2>", "."], "h": {"id": "C0935929", "name": "C0935929#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [12, 13]}}
{"token": ["Objectives", "of", "this", "study", "were", "to", "determine", "occurrence", "of", "C0262655#ent", "<e1>", "describe", "results", "of", "urine", "analysis", "urine", "culture", "dogs", "with", "experimentally", "induced", "C0271725#ent", "<e2>", "."], "h": {"id": "C0262655", "name": "C0262655#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0271725", "name": "C0271725#ent", "pos": [22, 23]}}
{"token": ["Further", ",", "the", "transcription", "of", "the", "uidA", "gene", "driven", "by", "the", "C3273591#ent", "<e1>", "promoter", "followed", "the", "same", "profile", "as", "for", "the", "C1418464#ent", "<e2>"], "h": {"id": "C3273591", "name": "C3273591#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418464", "name": "C1418464#ent", "pos": [21, 22]}}
{"token": ["Both", "DRz164", "and", "DRz256", "targeting", "C3273591#ent", "<e1>", "have", "the", "specific", "cleavage", "activity", "C3273591#ent", "<e1>", "mRNA", "in", "vitro", "can", "highly", "block", "the", "expression", "of", "C1418464#ent", "<e1>", "cellular", "milieu", "."], "h": {"id": "C3273591", "name": "C3273591#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418464", "name": "C1418464#ent", "pos": [23, 24]}}
{"token": ["C1420331#ent", "<e1>", "with", "a", "number", "of", "transcriptional", "cofactors", "a", "critical", "regulator", "in", "C1417679#ent", "<e2>", "such", "as", "COL2", ",", "chondorocyte", "specific", "gene", "."], "h": {"id": "C1420331", "name": "C1420331#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["The", "pattern", "of", "Runx1", "and", "C1420331#ent", "<e1>", "expression", "suggests", "that", "both", "C1417679#ent", "<e2>", "could", "potentially", "be", "involved", "in", "incipient", "intramembranous", "bone", "during", "craniofacial", "development"], "h": {"id": "C1420331", "name": "C1420331#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["Plasmid", "R753", "-", "1-encoded", "resistance", "to", "ampicillin", "(", "by", "production", "of", "OXA-1", "[", "type", "II", "C0005244#ent", "<e1>", ")", ",", "streptomycin", ",", "and", "C3536763#ent", "<e2>", "was", "analyzed", "functionally", "and", "physically", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3536763", "name": "C3536763#ent", "pos": [22, 23]}}
{"token": ["Nexopamil", "decreased", "left", "ventricular", "peak", "pressure", "LVPP", ")", "and", "pressure", "rate", "index", "(", "C3539761#ent", "<e1>", ")", "immediately", "before", "C0151814#ent", "<e2>", "11", "and", "18", "%", ",", "respectively", "."], "h": {"id": "C3539761", "name": "C3539761#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0151814", "name": "C0151814#ent", "pos": [18, 19]}}
{"token": ["A", "moderately", "vaginopathic", "strain", "(", "P", ")", "also", "expressed", "both", "C0017337#ent", "<e1>", ",", "but", "the", "level", "of", "C1414381#ent", "<e2>", "mRNA", "appeared", "to", "decrease", "prior", "to", "that", "of", "SAP2", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414381", "name": "C1414381#ent", "pos": [17, 18]}}
{"token": ["C0006684#ent", "<e1>", "to", "be", "used", "to", "treat", "congestive", "heart", "failure", "C0019099#ent", "<e2>", ")", ",", "despite", "clinical", "evidence", "they", "may", "exacerbate", "the", "disease", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [10, 11]}}
{"token": ["In", "order", "to", "assess", "the", "effects", "of", "C0006684#ent", "<e1>", "sympathetic", "nerve", "activity", "SNA", ")", "in", "experimental", "chronic", "heart", "failure", "C0019099#ent", "<e2>", ")", ",", "felodipine", "was", "given", "to", "rats", "with", "C0019099#ent", "<e2>", "induced", "by", "coronary", "artery", "ligation"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [19, 20]}}
{"token": ["Combinations", "of", "lopinavir", "with", "C0700483#ent", "<e1>", ",", "nelfinavir", ",", "amprenavir", ",", "tipranavir", ",", "and", "C0960815#ent", "<e2>", "generally", "displayed", "an", "additive", "relationship", "."], "h": {"id": "C0700483", "name": "C0700483#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0960815", "name": "C0960815#ent", "pos": [14, 15]}}
{"token": ["However", ",", "our", "results", "showed", "almost", "identical", "levels", "of", "peak", "calcium", "between", "wild-type", "or", "C1335191#ent", "<e1>", "null", "mice", "stimulated", "with", "either", "ADP", "or", "C0917834#ent", "<e2>", "."], "h": {"id": "C1335191", "name": "C1335191#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0917834", "name": "C0917834#ent", "pos": [23, 24]}}
{"token": ["An", "extension", "of", "implicit", "times", "of", "C2987131#ent", "<e1>", "were", "discovered", "starting", "with", "the", "group", "of", "patients", "with", "C0011849#ent", "<e2>", "lasting", "over", "5", "years", "."], "h": {"id": "C2987131", "name": "C2987131#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [17, 18]}}
{"token": ["The", "C0041964#ent", "<e1>", "0683", "is", "used", "in", "standard", "procedures", "identification", "of", "C4082696#ent", "<e2>", "variant", "by", "measuring", "residual", "activity", "two", "hours", "of", "inhibition", "."], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4082696", "name": "C4082696#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C1434353#ent", "<e1>", "is", "a", "functional", "homologue", "of", "C1425416#ent", "<e2>", "."], "h": {"id": "C1434353", "name": "C1434353#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1425416", "name": "C1425416#ent", "pos": [9, 10]}}
{"token": ["Following", "UV-irradiation", ",", "C1434353#ent", "<e1>", "transcription", "levels", "decrease", "significantly", ",", "but", "C1425416#ent", "<e2>", "change", "little", "."], "h": {"id": "C1434353", "name": "C1434353#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1425416", "name": "C1425416#ent", "pos": [11, 12]}}
{"token": ["The", "technique", "involves", "treatment", "of", "intact", ",", "agarose-solidified", "cell", "material", "with", "C1947941#ent", "<e1>", "in", "the", "presence", "of", "EDTA", "and", "C1426244#ent", "<e2>", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1426244", "name": "C1426244#ent", "pos": [19, 20]}}
{"token": ["Orchidectomy", "significantly", "increased", "C1705516#ent", "<e1>", "activity", "in", "the", "hypothalamus", ",", "\"", "C0002707#ent", "<e2>", ",", "\"", "and", "cerebellum", "but", "not", "in", "the", "cortex", "."], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002707", "name": "C0002707#ent", "pos": [11, 12]}}
{"token": ["Patterns", "of", "C1414435#ent", "<e1>", "isoenzymes", "in", "serum", "and", "muscle", "were", "specific", "to", "each", "C0026848#ent", "<e2>"], "h": {"id": "C1414435", "name": "C1414435#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [13, 14]}}
{"token": ["[M-H-R'xCH", "=", "C", "=", "O]-", "is", "attributed", "to", "the", "C0018834#ent", "<e1>", "of", "the", "gas", "phase", "ion", "of", "C1367455#ent", "<e2>", ",", "which", "undergoes", "a", "more", "facile", "neutral", "loss", "of", "acid", "than", "loss", "of", "ketene"], "h": {"id": "C0018834", "name": "C0018834#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367455", "name": "C1367455#ent", "pos": [17, 18]}}
{"token": ["Further", ",", "the", "expression", "of", "C1419788#ent", "<e1>", ",", "glutathione", "S-transferase", "pi", "PDGFRA", "and", "C0812222#ent", "<e2>", "were", "significantly", "induced", "in", "the", "tracheal", "epithelium", "Sprague", "Dawley", "rats", "formaldehyde", "inhalation"], "h": {"id": "C1419788", "name": "C1419788#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [13, 14]}}
{"token": ["Loss", "of", "function", "in", "the", "Nrf2", "inhibitor", ",", "Kelch-like", "ECH-associated", "protein", "C1427969#ent", "<e1>", ")", ",", "results", "in", "C0907533#ent", "<e2>", "activation", "of", "Nrf2", "function", "in", "non-small", "cell", "lung", "cancer"], "h": {"id": "C1427969", "name": "C1427969#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [17, 18]}}
{"token": ["C0221391#ent", "<e1>", "not", "require", "medical", "or", "surgical", "intervention", "is", "considered", "a", "benign", "C0549567#ent", "<e2>"], "h": {"id": "C0221391", "name": "C0221391#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0549567", "name": "C0549567#ent", "pos": [12, 13]}}
{"token": ["A", "novel", "class", "of", "competitive", ",", "C0003015#ent", "<e1>", "the", "proline-specific", "peptidases", ":", "C1447020#ent", "<e2>", "dipeptidyl", "peptidase", "II", "prolyl", "endopeptidase", "has", "been", "developed", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1447020", "name": "C1447020#ent", "pos": [12, 13]}}
{"token": ["Prolactin", "treatment", "a", "C0003289#ent", "<e1>", "effect", "on", "endogenous", "prolactin", "and", "C2757070#ent", "<e2>", "levels", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [10, 11]}}
{"token": ["C0116569#ent", "<e1>", "was", "effective", "in", "alleviating", "C0002962#ent", "<e2>", "18", "of", "the", "21", "patients", "."], "h": {"id": "C0116569", "name": "C0116569#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [6, 7]}}
{"token": ["The", "hope", "is", "that", "by", "studying", "how", "C0752312#ent", "<e1>", "is", "activated", "by", "different", "C0243051#ent", "<e2>", "the", "ensuing", "downstream", "cellular", "modifications", "the", "molecular", "basis", "memory", "will", "be", "ultimately", "understood", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [13, 14]}}
{"token": ["Recent", "studies", "have", "emphasized", "the", "role", "of", "C0752312#ent", "<e1>", "pERK1", "and", "2", ")", "in", "coupling", "rapid", "events", "such", "as", "C0243051#ent", "<e2>", "release", "and", "receptor", "stimulation", "changes", "in", "synaptic", "plasticity", "and", "cell", "survival"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [19, 20]}}
{"token": ["This", "time-dependent", "effect", "was", "blocked", "by", "ibuprofen", "but", "not", "by", "C0036079#ent", "<e1>", "sulindac", ",", "acetaminophen", "or", "to", "any", "significant", "extent", "by", "C0022635#ent", "<e2>", "and", "naproxen", "."], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022635", "name": "C0022635#ent", "pos": [21, 22]}}
{"token": ["New", "organogels", "containing", "C0036079#ent", "<e1>", "sodium", "salicylate", "procaine", ",", "and", "C0022635#ent", "<e2>", "were", "prepared", "by", "using", "Eudragit", "L", "S", ",", "and", "propylene", "glycol"], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022635", "name": "C0022635#ent", "pos": [10, 11]}}
{"token": ["AAs", "appear", "to", "mediate", "this", "response", "through", "C2936426#ent", "<e1>", "PI3K", ",", "or", "human", "vacuolar", "protein", "sorting", "34", "C3853886#ent", "<e2>", ")", ",", "rather", "than", "through", "the", "canonical", "class", "I", "PI3K", "pathway", "by", "growth", "factors", "hormones", "."], "h": {"id": "C2936426", "name": "C2936426#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3853886", "name": "C3853886#ent", "pos": [17, 18]}}
{"token": ["There", "was", "variation", "in", "the", "copy-number", "of", "21-OHA", "C0079429#ent", "<e1>", "among", "patients", "with", "C0520463#ent", "<e2>", ",", "yet", "no", "difference", "was", "found", "between", "the", "patients", "and", "normal", "persons"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0520463", "name": "C0520463#ent", "pos": [13, 14]}}
{"token": ["Testis", "cytosol", "shown", "to", "contain", "the", "Yb2Yb2", "-homodimer", "C0537086#ent", "<e1>", "addition", "to", "the", "previously", "described", "glutathione", "S-transferases", "A", "C1823882#ent", "<e2>", ")", "and", "C", "(", "Yb1Yb2", ")", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1823882", "name": "C1823882#ent", "pos": [18, 19]}}
{"token": ["Structures", "of", "inhibitors", "in", "complex", "with", "both", "wild-type", "and", "mutant", "C0031727#ent", "<e1>", "reveal", "similar", "binding", "modes", "C1122962#ent", "<e2>", "and", "AEE788", ",", "but", "a", "marked", "rotation", "of", "the", "staurosporine", "in", "the", "G719S", "mutant", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1122962", "name": "C1122962#ent", "pos": [16, 17]}}
{"token": ["Although", "directional", "changes", "in", "lipoprotein", "lipase", "LpL", ")", "and", "hepatic", "triglyceride", "lipase", "HTGL", ")", "similar", "to", "those", "found", "in", "C3273872#ent", "<e1>", "after", "MDI", "and", "C3273618#ent", "<e2>", "were", "observed", ",", "they", "were", "not", "statistically", "significant"], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3273618", "name": "C3273618#ent", "pos": [24, 25]}}
{"token": ["C0031117#ent", "<e1>", "the", "most", "frequent", "neurological", "complication", "C3854222#ent", "<e2>", "infection", "and", "is", "commonly", "associated", "with", "development", "of", "chronic", "pain"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [7, 8]}}
{"token": ["The", "etiopathogenesis", "of", "C0031117#ent", "<e1>", "PN", ")", "that", "frequently", "affects", "C3854222#ent", "<e2>", "HIV", ")", "type", "1-positive", "patients", "remains", "undefined", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [10, 11]}}
{"token": ["Twenty", "five", "patients", "with", "C0031117#ent", "<e1>", "different", "stages", "of", "C3854222#ent", "<e2>", "HIV", ")", "infection", "are", "reported", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [9, 10]}}
{"token": ["Abnormal", "MI", "firing", "patterns", "and", "synchronization", ",", "rather", "than", "reduced", "firing", "rates", ",", "may", "underlie", "C3160718#ent", "<e1>", "akinesia", "and", "persistent", "C0026837#ent", "<e2>"], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [20, 21]}}
{"token": ["Peptic", "ulcer", "diarrhea", "of", "C0043515#ent", "<e1>", "other", "acid", "hypersecretory", "states", "respond", "to", "C0008783#ent", "<e2>", "treatment", ",", "as", "may", "stress", "ulcers", "steatorrhea", "of", "patients", "with", "pancreatic", "insuffficiency", "have", "a", "suboptimol", "response", "to", "oral", "pancreatin"], "h": {"id": "C0043515", "name": "C0043515#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [12, 13]}}
{"token": ["A", "study", "has", "been", "made", "of", "the", "gastric", "secretions", "a", "patient", "with", "C0043515#ent", "<e1>", "peptic", "ulceration", "before", "and", "after", "treatment", "with", "C0008783#ent", "<e2>", "."], "h": {"id": "C0043515", "name": "C0043515#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [21, 22]}}
{"token": ["This", "is", "corroborated", "by", "the", "fact", "that", "overexpression", "of", "the", "44", "kDa", "C3890185#ent", "<e1>", "in", "prostate", "cancer", "cells", "confers", "the", "resistance", "to", "C0033978#ent", "<e2>"], "h": {"id": "C3890185", "name": "C3890185#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [22, 23]}}
{"token": ["Endogenous", "expression", "of", "ESX", "results", "in", "a", "42", "kDa", "nuclear", "protein", "fivefold", "greater", "affinity", "for", "the", "chromatin-nuclear", "matrix", "compartment", "as", "compared", "to", "other", "endogenous", "transcription", "factors", "C0919496#ent", "<e1>", "and", "the", "C1333333#ent", "<e2>", "ELF-1", "."], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1333333", "name": "C1333333#ent", "pos": [30, 31]}}
{"token": ["However", ",", "derepression", "of", "recE", "seems", "to", "be", "independent", "of", "the", "ATP-dependent", "DNase", "of", "the", "C0059946#ent", "<e1>", "also", "called", "C0913945#ent", "<e2>", "."], "h": {"id": "C0059946", "name": "C0059946#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0913945", "name": "C0913945#ent", "pos": [19, 20]}}
{"token": ["These", "results", "indicate", "that", "C0122445#ent", "<e1>", "is", "a", "potent", "centrally", "acting", "C2911818#ent", "<e2>", "that", "its", "central", "nervous", "system", "activity", "is", "relatively", "weak", "."], "h": {"id": "C0122445", "name": "C0122445#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2911818", "name": "C2911818#ent", "pos": [11, 12]}}
{"token": ["These", "changes", "were", "not", "attributable", "to", "a", "defect", "in", "hedgehog", "signaling", "suggesting", "that", "they", "arise", "from", "C0268487#ent", "<e1>", "in", "other", "C0062505#ent", "<e2>", "sulfate-dependent", "pathways", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0062505", "name": "C0062505#ent", "pos": [20, 21]}}
{"token": ["Guanine", "nucleotide", "binding", "protein", "G", "protein)-linked", "receptors", ",", "the", "alpha-subunits", "of", "heterotrimeric", "G", "proteins", "members", "of", "the", "Src", "family", "C1336653#ent", "<e1>", "among", "many", "C1305923#ent", "<e2>", "that", "are", "posttranslationally", "modified", "by", "the", "addition", "of", "palmitate", ",", "a", "long-chain", "fatty", "acid"], "h": {"id": "C1336653", "name": "C1336653#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [23, 24]}}
{"token": ["Instead", ",", "C0031622#ent", "<e1>", "cytidine", "5'-diphosphate-diglyceride", ":", "L-serine", "phosphatidyl", "transferase", "and", "C1418591#ent", "<e2>", "detected", ",", "although", "at", "low", "levels", "."], "h": {"id": "C0031622", "name": "C0031622#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418591", "name": "C1418591#ent", "pos": [11, 12]}}
{"token": ["The", "principal", "membrane", "components", "are", "microsomes", "(", "source", "of", "C0031622#ent", "<e1>", "and", "mitochondria", "(", "source", "of", "C1418591#ent", "<e2>", "."], "h": {"id": "C0031622", "name": "C0031622#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418591", "name": "C1418591#ent", "pos": [16, 17]}}
{"token": ["Migrating", "T", "cells", "increased", "expression", "of", "activation", "marker", "C3540471#ent", "<e1>", "and", "chemokine", "receptors", "CXCR3", ",", "CCR4", ",", "and", "C1332703#ent", "<e2>", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332703", "name": "C1332703#ent", "pos": [18, 19]}}
{"token": ["Five", "urinary", "metabolites", "2-mercaptobenzothiazole", "(", "C1335267#ent", "<e1>", ")", ",", "its", "three", "conjugates", ",", "C0178741#ent", "<e2>", ",", "glucuronide", "and", "sulfate", ",", "and", "2,2'-dibenzothiazyl", "disulfide", "(", "BTDS", ")", "were", "confirmed", "."], "h": {"id": "C1335267", "name": "C1335267#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0178741", "name": "C0178741#ent", "pos": [13, 14]}}
{"token": ["To", "test", "the", "hypothesis", "that", "nabumetone", "(", "a", "partially", "selective", "cyclooxygenase-(COX)-2", "inhibitor", "has", "less", "effect", "on", "platelet", "aggregation", "C0027396#ent", "<e1>", "(", "a", "non-selective", "COX-inhibitor", ")", "in", "patients", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [30, 31]}}
{"token": ["The", "investigation", "consisted", "of", "a", "double-blind", "cross-over", "study", "the", "effect", "of", "75", "mg", "indometacin", ",", "500", "mg", "C0027396#ent", "<e1>", "or", "a", "placebo", "in", "63", "patients", "with", "C0003873#ent", "<e2>", "by", "night", "pain", "morning", "stiffness"], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [26, 27]}}
{"token": ["In", "contrast", ",", "the", "mRNAs", "of", "calsequestrin", "and", "C1418650#ent", "<e1>", "were", "unchanged", "in", "dogs", "with", "either", "congestive", "heart", "failure", "C3887648#ent", "<e2>", "infusion", "."], "h": {"id": "C1418650", "name": "C1418650#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [19, 20]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "whether", "colonic", "epithelial", "cells", "C1705074#ent", "<e1>", "and", "whether", "its", "expression", "is", "upregulated", "in", "C0010346#ent", "<e2>"], "h": {"id": "C1705074", "name": "C1705074#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [21, 22]}}
{"token": ["A", "case", "of", "bilateral", "Anterior", "Ischemic", "Optic", "Neuropathy", "C2697648#ent", "<e1>", ")", "which", "is", "related", "to", "buried", "C0029128#ent", "<e2>", "presented", "."], "h": {"id": "C2697648", "name": "C2697648#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029128", "name": "C0029128#ent", "pos": [16, 17]}}
{"token": ["Among", "these", "compounds", ",", "(E)-(5)-(3,5-di-tert-butyl-4-hydroxybenzylidence)-2-ethyl-1,2-", "isothiazolidine-1,1-dioxide", "(", "C3658183#ent", "<e1>", ")", "was", "selected", "as", "an", "C0596107#ent", "<e2>", "."], "h": {"id": "C3658183", "name": "C3658183#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0596107", "name": "C0596107#ent", "pos": [14, 15]}}
{"token": ["Risk", "factors", "erectile", "dysfunction", "certain", "medications", ",", "such", "as", "cardiovascular", "medications", "C0033978#ent", "<e1>", "and", "chronic", "diseases", "particularly", "C0027765#ent", "<e2>", "diabetes", "mellitus"], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [17, 18]}}
{"token": ["These", "designer", "drugs", "comprise", "analogs", "of", "many", "different", "classes", "of", "C0033978#ent", "<e1>", "present", "a", "spectrum", "of", "adverse", "health", "effects", "from", "mood", "changes", "severe", "C0027765#ent", "<e2>"], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [23, 24]}}
{"token": ["We", "developed", "an", "oleic", "acid", "oil-in-water", "(o/w)-type", "emulsion", "of", "a", "new", "C0085149#ent", "<e1>", "presented", "an", "improvement", "in", "the", "delivery", "of", "the", "C1254351#ent", "<e2>", "for", "oral", "absorption"], "h": {"id": "C0085149", "name": "C0085149#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [21, 22]}}
{"token": ["Since", "tacrolimus", "strongly", "inhibits", "T", "cell", "activation", "C0085149#ent", "<e1>", "been", "developed", "as", "a", "novel", "C1254351#ent", "<e2>", "for", "AD", "throughout", "the", "world", "."], "h": {"id": "C0085149", "name": "C0085149#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["Type", "1", "diabetes", "considered", "to", "be", "a", "C0004364#ent", "<e1>", "by", "gradual", "beta-cell", "destruction", "by", "autoreactive", "T-lymphocytes", "during", "an", "asymptomatic", "C0362046#ent", "<e2>", "varying", "duration", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [19, 20]}}
{"token": ["This", "demonstrates", "the", "lack", "of", "significance", "of", "episodes", "of", "VT", "during", "Ajmaline", "tests", "the", "C0003289#ent", "<e1>", "action", "of", "the", "C1254351#ent", "<e2>", "on", "intracardiac", "conduction", "the", "initiation", "of", "reentry", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [19, 20]}}
{"token": ["C0012798#ent", "<e1>", "such", "as", "furosemide", ",", "most", "nephrotoxic", "agents", "cyclosporine", "A", "C0751039#ent", "<e2>", "]", ",", "heavy", "metals", "and", "imidazole", "reduce", "the", "GFR", "significantly", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [11, 12]}}
{"token": ["Clinical", "efficacy", "demonstrated", "in", "several", "large", "phase", "II/III", "studies", "in", "C0029896#ent", "<e1>", "such", "as", "oral", "and", "oesophageal", "candidosis", "C0276653#ent", "<e2>", "chronic", "invasive", "aspergillosis"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0276653", "name": "C0276653#ent", "pos": [18, 19]}}
{"token": ["Also", ",", "5", "out", "of", "6", "clones", "of", "stable", "fusion", "cells", "C1417830#ent", "<e1>", "and", "parent", "cells", "the", "parental", "type", "of", "responses", "to", "TPA", "and", "growth", "factors", "indicating", "that", "the", "C1417830#ent", "<e1>", "phenotype", "is", "C0017361#ent", "<e1>", "."], "h": {"id": "C1417830", "name": "C1417830#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [33, 34]}}
{"token": ["Glycoproteins", "C1422611#ent", "<e1>", "and", "GPIb-IX-V", "stimulate", "robust", "tyrosine", "phosphorylation", "Syk", "and", "PLCg2", "(", "C0031672#ent", "<e2>", "in", "washed", "platelets", ",", "but", "only", "the", "former", "stimulates", "pronounced", "activation", "of", "phospholipase", "."], "h": {"id": "C1422611", "name": "C1422611#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031672", "name": "C0031672#ent", "pos": [13, 14]}}
{"token": ["There", "was", "one", "episode", "of", "C0032285#ent", "<e1>", "in", "the", "selective", "decontamination", "group", "and", "five", "in", "the", "C0038633#ent", "<e2>", "group", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0038633", "name": "C0038633#ent", "pos": [16, 17]}}
{"token": ["Deletion", "of", "the", "C0796520#ent", "<e1>", "HLH", "domain", "abolished", "dimer", "formation", "either", "C0796520#ent", "<e1>", "or", "C3275265#ent", "<e1>", ",", "and", "cells", "expressing", "this", "mutant", "protein", "morphologically", "non-transformed", "and", "failed", "to", "grow", "in", "soft", "agar"], "h": {"id": "C0796520", "name": "C0796520#ent", "pos": [3, 4]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3275265", "name": "C3275265#ent", "pos": [14, 15]}}
{"token": ["The", "released", "iron", "may", "promote", "microsomal", "phospholipid", "peroxidation", "in", "the", "presence", "of", "endogenous", "ascorbate", "or", "NADPH-dependent", "cytochrome", "P-450", "reductase", "C0003967#ent", "<e1>", "p-chloromercuribenzoic", "acid", "an", "inhibitor", "of", "C0072354#ent", "<e2>", "inhibited", "metHb-", "or", "HbO2-induced", "lipid", "peroxidation"], "h": {"id": "C0003967", "name": "C0003967#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0072354", "name": "C0072354#ent", "pos": [26, 27]}}
{"token": ["Pretreatment", "of", "diabetic", "mice", "with", "C0003015#ent", "<e1>", "allopurinol", "and", "its", "active", "metabolite", "C0030086#ent", "<e2>", ",", "normalized", "the", "increased", "superoxide", "generation"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030086", "name": "C0030086#ent", "pos": [12, 13]}}
{"token": ["Immunohistochemistry", "was", "carried", "out", "by", "using", "antibodies", "against", "estrogen", "receptor", "ER", ")", ",", "C1366500#ent", "<e1>", "PR", ")", ",", "HER-2/neu", ",", "p53", "and", "C0007428#ent", "<e2>", "D.", "In", "60/83", "high-grade", "carcinomas", "studied", "the", "mammographic", "appearance", "."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [22, 23]}}
{"token": ["This", "study", "used", "endometrial", "cathepsin", "D", "expression", "both", "as", "an", "indirect", "marker", "for", "the", "functional", "status", "C1366500#ent", "<e1>", "and", "to", "identify", "the", "cell", "types", "express", "C0007428#ent", "<e2>", "D."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [25, 26]}}
{"token": ["We", "treated", "20", "early", "Parkinson's", "disease", "subjects", "with", "the", "C0178601#ent", "<e1>", "combination", "with", "the", "C2917433#ent", "<e2>", "selegiline", "(", "L-deprenyl", ")", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2917433", "name": "C2917433#ent", "pos": [14, 15]}}
{"token": ["Transgenic", "mice", "express", "boar", "C1412134#ent", "<e1>", "were", "produced", "to", "examine", "mechanisms", "for", "targeting", "hydrolytic", "C3541394#ent", "<e2>", "to", "the", "acrosome", "."], "h": {"id": "C1412134", "name": "C1412134#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "three", "cancer", "tissues", "immunohistochemically", "aberrant", "accumulation", "of", "beta-catenin", "in", "the", "nucleus", "and/or", "cytoplasm", "revealed", "down-regulation", "of", "Siah", "and", "C1332125#ent", "<e1>", "up-regulation", "of", "Wnt", "and", "C0079068#ent", "<e2>", "genes", "."], "h": {"id": "C1332125", "name": "C1332125#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [26, 27]}}
{"token": ["Incubation", "with", "serum-treated", "zymosan", "(", "C1539862#ent", "<e1>", ")", "stimulated", "the", "expression", "of", "C1705323#ent", "<e2>", "in", "a", "time-", "and", "dose-dependent", "manner", "."], "h": {"id": "C1539862", "name": "C1539862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [12, 13]}}
{"token": ["To", "compare", "the", "cost", "of", "care", "for", "C0038013#ent", "<e1>", "RA", ")", "patients", "treated", "with", "adalimumab", ",", "infliximab", ",", "and", "C0717758#ent", "<e2>", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0717758", "name": "C0717758#ent", "pos": [19, 20]}}
{"token": ["The", "authors", "report", "a", "case", "of", "acute", "C0029221#ent", "<e1>", "a", "patient", "being", "treated", "with", "clonidine", "and", "C0016368#ent", "<e2>", "that", "cleared", "when", "clonidine", "was", "discontinued", "."], "h": {"id": "C0029221", "name": "C0029221#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [16, 17]}}
{"token": ["These", "results", "provide", "strong", "evidence", "that", "certain", "WRKY", "C1417679#ent", "<e1>", "act", "upstream", "of", "C1417810#ent", "<e2>", "and", "positively", "regulate", "its", "expression", "during", "the", "activation", "of", "plant", "defense", "responses"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417810", "name": "C1417810#ent", "pos": [13, 14]}}
{"token": ["The", "studies", "within", "indicated", "that", "the", "ss", "endonuclease", "activity", "C1332102#ent", "<e1>", "is", "poorly", "active", "on", "C0085077#ent", "<e2>", "polyadenine", "or", "polythymine", "oligonucleotides", "suggesting", "a", "requirement", "for", "some", "form", "of", "DNA", "secondary", "structure", "efficient", "cleavage", "."], "h": {"id": "C1332102", "name": "C1332102#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085077", "name": "C0085077#ent", "pos": [15, 16]}}
{"token": ["This", "RAD6", "derivative", "out", "the", "stress-related", "function", "of", "C1710517#ent", "<e1>", "and", "the", "cell", "cycle", "function", "C3540505#ent", "<e2>", "while", "maintaining", "its", "own", "DNA", "repair", "function"], "h": {"id": "C1710517", "name": "C1710517#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540505", "name": "C3540505#ent", "pos": [15, 16]}}
{"token": ["Seven", "patients", "presented", "with", "a", "C1405128#ent", "<e1>", "the", "context", "of", "C0149521#ent", "<e2>"], "h": {"id": "C1405128", "name": "C1405128#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [10, 11]}}
{"token": ["Neither", "the", "5-FMT-", "nor", "the", "8-hydroxy-2-(di-n-propylamino)tetralin", "(5-HT1A-agonist)-induced", "5-HT", "syndrome", "(", "C0232602#ent", "<e1>", "hindlimb", "abduction", "was", "affected", "by", "gamma-mangostin", "or", "C1517662#ent", "<e2>", "."], "h": {"id": "C0232602", "name": "C0232602#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "neither", "l-5-HTP", "plus", "clorgyline", "nor", "5-HT1A", "agonist", "8-hydroxy-2-(di-n-propylamino)tetraline", "(", "8-OH-DPAT", ";", "5", "microg/mouse", ",", "i.c.v.)-induced", "C0232602#ent", "<e1>", "affected", "by", "nantenine", "or", "C1517662#ent", "<e2>", "."], "h": {"id": "C0232602", "name": "C0232602#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [24, 25]}}
{"token": ["This", "scenario", "has", "been", "revolutionised", "by", "the", "introduction", "into", "clinical", "parasitology", "the", "benzimidazole", "compounds", "praziquantel", "(", "and", "other", "C0036336#ent", "<e1>", "and", "ivermectin", "for", "helminthiases", ",", "and", "the", "5-nitroimidazoles", "for", "C0033741#ent", "<e2>"], "h": {"id": "C0036336", "name": "C0036336#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0033741", "name": "C0033741#ent", "pos": [29, 30]}}
{"token": ["Previous", "studies", "indicated", "that", "aspirin", "(", "C0050537#ent", "<e1>", "ASA", "]", ")", "can", "have", "profound", "immunomodulatory", "effects", "regulating", "C1333196#ent", "<e2>", "expression", "in", "several", "types", "of", "cells", "."], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [17, 18]}}
{"token": ["In", "1", "mM", "C1413043#ent", "<e1>", "+", "and", "150", "mM", "KCl", ",", "C1421449#ent", "<e2>", "and", "gelsolin", "have", "similar", "severing", "and", "polymerization-accelerating", "properties", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421449", "name": "C1421449#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "report", "that", "human", "TLF", "(", "also", "called", "C1336594#ent", "<e1>", "TRF2", "]", ")", "activates", "a", "number", "of", "different", "C0017337#ent", "<e2>", ",", "including", "the", "neurofibromatosis", "type", "1", "NF1", ")", "gene", "."], "h": {"id": "C1336594", "name": "C1336594#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "GEF", "activity", "toward", "C1419407#ent", "<e1>", "remained", "latent", ",", "implying", "that", "C1540033#ent", "<e2>", "does", "not", "represent", "a", "tyrosine", "kinase", "acts", "downstream", "of", "G", "protein-coupled", "receptors"], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1540033", "name": "C1540033#ent", "pos": [13, 14]}}
{"token": ["We", "have", "utilized", "an", "amber", "MURFI", "linker", ",", "5'CTAG", "C1336599#ent", "<e1>", "CTAG3", "'", "to", "disrupt", "the", "lacZ", "gene", "yielding", "C0005220#ent", "<e2>"], "h": {"id": "C1336599", "name": "C1336599#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [19, 20]}}
{"token": ["The", "DVD", "sites", "bind", "to", "their", "specific", "C0211705#ent", "<e1>", "MAPKKKs", ")", ",", "including", "MTK1", "(", "MEKK4", ")", ",", "C3811165#ent", "<e2>", ",", "TAK1", ",", "TAO2", ",", "MEKK1", ",", "and", "Raf-1", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811165", "name": "C3811165#ent", "pos": [18, 19]}}
{"token": ["The", "antigen-presenting", "cells", "for", "TS1", "induction", "lack", "the", "Thy-1", "and", "C1704849#ent", "<e1>", "markers", ",", "and", "are", "resistant", "to", "500", "R", "irradiation", "to", "C1161438#ent", "<e2>", "treatment", "."], "h": {"id": "C1704849", "name": "C1704849#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [22, 23]}}
{"token": ["These", "results", "demonstrate", "that", "cell", "adhesion", "deadhesion", "rapidly", "and", "reversibly", "modify", "both", "C1333196#ent", "<e1>", "mRNA", "stability", "the", "RNA-binding", "complexes", "associated", "with", "C3540626#ent", "<e2>", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540626", "name": "C3540626#ent", "pos": [21, 22]}}
{"token": ["C0649938#ent", "<e1>", "and", "yohimbine", "weakened", "shaking", "response", "to", "C0006945#ent", "<e2>", "but", "phentolamine", "given", "ICV", "showed", "no", "effect", "WDS", "."], "h": {"id": "C0649938", "name": "C0649938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [8, 9]}}
{"token": ["The", "expression", "of", "C1366571#ent", "<e1>", ",", "RANTES", ",", "and", "GM-CSF", "messenger", "ribonucleic", "acid", "not", "inhibited", "by", "C0072032#ent", "<e2>", "and", "theophylline", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072032", "name": "C0072032#ent", "pos": [16, 17]}}
{"token": ["The", "cell", "types", "normal", "rat", "anterior", "pituitary", "TGF", "C1420369#ent", "<e1>", ",", "one", "of", "the", "principal", "isoforms", "TGF", "beta", ",", "and", "C1420433#ent", "<e2>", "were", "examined", "by", "in", "situ", "methods"], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420433", "name": "C1420433#ent", "pos": [20, 21]}}
{"token": ["Recognition", "of", "C0015300#ent", "<e1>", "as", "a", "part", "of", "C2931196#ent", "<e2>", "the", "easy", "visualization", "of", "the", "eye", "balls", "and", "palpebrae", "in", "the", "third", "trimester", "the", "diagnosis", "possible", "."], "h": {"id": "C0015300", "name": "C0015300#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C2931196", "name": "C2931196#ent", "pos": [8, 9]}}
{"token": ["C0055461#ent", "<e1>", ",", "ergotamine", ",", "ethaverine", "and", "chronic", "abuse", "C0242937#ent", "<e2>", "to", "be", "responsible", "for", "the", "drug-induced", "cutaneous", "neuro-phospholipidosis", ",", "whereas", "the", "same", "condition", "was", "found", "in", "two", "patients", "with", "metastatic", "bronchogenic", "carcinoma", "malignant", "melanoma"], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242937", "name": "C0242937#ent", "pos": [9, 10]}}
{"token": ["These", "results", "offer", "biochemical", "support", "for", "the", "hypothesis", "that", "excitatory", "neurones", "innervating", "the", "C1412409#ent", "<e1>", "via", "the", "indirect", "striatal", "output", "pathway", ",", "may", "utilise", "C0017789#ent", "<e2>", "and/or", "aspartate", "as", "their", "neurotransmitter", "."], "h": {"id": "C1412409", "name": "C1412409#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [24, 25]}}
{"token": ["As", "FE8", "was", "shown", "to", "recognize", "a", "discontinuous", "epitope", "a", "series", "of", "overlapping", "C0030956#ent", "<e1>", "derived", "from", "C1413694#ent", "<e2>", "and", "-2", "and", "immobilized", "on", "cellulose", "was", "screened", "with", "FE8", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413694", "name": "C1413694#ent", "pos": [17, 18]}}
{"token": ["Sequencing", "of", "amino-terminal", "and", "internal", "C0030956#ent", "<e1>", "from", "the", "C1413694#ent", "<e2>", "a", "proline-rich", "region", "approximately", "20", "amino", "acids", "a", "signal", "peptide", "had", "not", "been", "previously", "reported", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413694", "name": "C1413694#ent", "pos": [9, 10]}}
{"token": ["The", "C0070302#ent", "<e1>", "bone", "cement", "complete", "biocompatibility", "with", "no", "interference", "C0011434#ent", "<e2>"], "h": {"id": "C0070302", "name": "C0070302#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011434", "name": "C0011434#ent", "pos": [10, 11]}}
{"token": ["We", "recently", "isolated", "an", "C1427925#ent", "<e1>", "rat", "liver", "nuclei", "and", "found", "it", "to", "be", "C1334043#ent", "<e2>", "to", "the", "product", "of", "the", "human", "ELL", "gene", ",", "a", "frequent", "target", "for", "translocations", "in", "acute", "myeloid", "leukemia"], "h": {"id": "C1427925", "name": "C1427925#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}}
{"token": ["Subarachnoid", "hemorrhage", "C1825840#ent", "<e1>", ")", "frequently", "results", "in", "C0027051#ent", "<e2>", "release", "of", "cardiac", "enzymes"], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [8, 9]}}
{"token": ["A", "total", "of", "178", "men", "with", "C0020619#ent", "<e1>", "ED", "received", "C0086214#ent", "<e2>", "4", "months", "."], "h": {"id": "C0020619", "name": "C0020619#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086214", "name": "C0086214#ent", "pos": [10, 11]}}
{"token": ["All", "eight", "patients", "experienced", "severe", "C0858786#ent", "<e1>", "which", "necessitated", "discontinuation", "of", "C0010592#ent", "<e2>", "six", "."], "h": {"id": "C0858786", "name": "C0858786#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}}
{"token": ["The", "C0009118#ent", "<e1>", "MRSA", "isolated", "from", "the", "hospital", "staff", "patients", "were", "C3273406#ent", "<e2>", ",", "IV", "and", "VII", ",", "although", "those", "of", "Methicillin-sensitive", "S.", "aureus", "(", "MSSA", ")", "consisted", "of", "all", "types", "."], "h": {"id": "C0009118", "name": "C0009118#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [11, 12]}}
{"token": ["The", "mean", "exercise", "C0720099#ent", "<e1>", "was", "comparable", "for", "patients", "with", "C3275121#ent", "<e2>", "453", "+", "/-", "174", "s", ")", "and", "single", "vessel", "disease", "476", "+", "/-", "166", "s", ")", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [10, 11]}}
{"token": ["We", "found", "that", "resveratrol", "represses", "different", "classes", "of", "androgen", "up-regulated", "genes", "at", "the", "protein", "or", "mRNA", "level", "including", "prostate-specific", "antigen", "human", "C0618743#ent", "<e1>", "AR-specific", "coactivator", "ARA70", ",", "and", "the", "cyclin-dependent", "kinase", "inhibitor", "C3470429#ent", "<e2>", "."], "h": {"id": "C0618743", "name": "C0618743#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [32, 33]}}
{"token": ["Intravenous", "C0700546#ent", "<e1>", "administered", "to", "patients", "with", "C0026769#ent", "<e2>", "MS", ")", "during", "exacerbations", "to", "improve", "the", "rate", "of", "recovery", "."], "h": {"id": "C0700546", "name": "C0700546#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [7, 8]}}
{"token": ["Mutations", "in", "human", "C0062941#ent", "<e1>", "and", "other", "Hh", "pathway", "components", "have", "been", "linked", "to", "C0029896#ent", "<e2>"], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}}
{"token": ["C0019340#ent", "<e1>", "frequently", "during", "this", "C0039082#ent", "<e2>", ",", "the", "lesions", "lasting", "above", "six", "weeks", "associated", "to", "anal", "or", "genital", "localizations", "."], "h": {"id": "C0019340", "name": "C0019340#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [5, 6]}}
{"token": ["Oxidative", "stress", "neuronal", "precursor", "cells", "to", "downregulation", "of", "nestin", "with", "subsequent", "activation", "of", "cyclin-dependent", "kinase", "5", "C1565306#ent", "<e1>", ")", ",", "a", "crucial", "C0031727#ent", "<e2>", "in", "the", "nervous", "system"], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [16, 17]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}}
{"token": ["One", "hundred", "and", "one", "depressed", "inpatients", "treated", "by", "authors", "with", "a", "second-generation", "antidepressive", "original", "molecule", "C0076804#ent", "<e1>", ",", "a", "specific", "and", "reversible", "C0026454#ent", "<e2>", "inhibitor", "."], "h": {"id": "C0076804", "name": "C0076804#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [22, 23]}}
{"token": ["C0076804#ent", "<e1>", "reversibly", "inhibited", "C0026454#ent", "<e2>", "but", "did", "not", "affect", "the", "activity", "of", "type", "B", "MAO", "whole", "brain"], "h": {"id": "C0076804", "name": "C0076804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [4, 5]}}
{"token": ["We", "examined", "the", "influence", "of", "C0076804#ent", "<e1>", ",", "a", "new", "reversible", "C0026454#ent", "<e2>", "inhibitor", "used", "in", "the", "treatment", "of", "depression", ",", "on", "tyramine-induced", "pressor", "effect", "in", "healthy", "volunteers"], "h": {"id": "C0076804", "name": "C0076804#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [11, 12]}}
{"token": ["The", "enzyme", "can", "selectively", "recognize", "GA", "even", "in", "the", "presence", "of", "large", "excess", "of", "C0007804#ent", "<e1>", "and", "its", "metabolic", "derivatives", "C1742019#ent", "<e2>", "SA", ")", "and", "salicyluric", "acid", "SUA", ")", ")", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [20, 21]}}
{"token": ["C0007804#ent", "<e1>", ",", "but", "not", "C1742019#ent", "<e2>", "inhibited", "glycation", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [5, 6]}}
{"token": ["We", "propose", "that", "HtrA1", "regulates", "mineralization", "by", "inhibiting", "TGF-beta/BMP", "signalling", "and/or", "by", "cleaving", "specific", "matrix", "proteins", "including", "C0057252#ent", "<e1>", "and", "MGP", "(", "C1334506#ent", "<e2>", "."], "h": {"id": "C0057252", "name": "C0057252#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334506", "name": "C1334506#ent", "pos": [22, 23]}}
{"token": ["A", "renal", "biopsy", "days", "after", "the", "onset", "of", "C0027697#ent", "<e1>", "showed", "mild", "C0268747#ent", "<e2>", "proliferative", "changes", "and", "one", "segmental", "sclerotic", "lesion", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268747", "name": "C0268747#ent", "pos": [12, 13]}}
{"token": ["In", "C0027697#ent", "<e1>", "immune", "deposits", "seen", "in", "C0268747#ent", "<e2>", ",", "subendothelial", ",", "intramembranous", "and", "subepithelial", "areas", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268747", "name": "C0268747#ent", "pos": [7, 8]}}
{"token": ["In", "neuroendocrine", "PC12", "cells", "SCAMP2", "colocalizes", "on", "the", "cell", "surface", "three", "other", "proteins", "required", "for", "dense-core", "vesicle", "exocytosis", "C1418641#ent", "<e1>", "PLD1", ")", ",", "the", "small", "GTPase", "Arf6", "and", "Arf6", "C0120465#ent", "<e2>", "ARNO", "."], "h": {"id": "C1418641", "name": "C1418641#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [29, 30]}}
{"token": ["In", "neuroendocrine", "PC12", "cells", "SCAMP2", "colocalizes", "on", "the", "cell", "surface", "three", "other", "proteins", "required", "for", "dense-core", "vesicle", "exocytosis", "phospholipase", "D1", "C1418641#ent", "<e1>", ")", ",", "the", "small", "GTPase", "Arf6", "and", "Arf6", "C0120465#ent", "<e2>", "ARNO", "."], "h": {"id": "C1418641", "name": "C1418641#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [30, 31]}}
{"token": ["Reduced", "bone", "mineral", "density", "BMD", ")", ",", "the", "major", "risk", "factor", "osteoporotic", "fracture", "has", "been", "linked", "to", "C0030246#ent", "<e1>", "but", "no", "significant", "studies", "have", "examined", "BMD", "in", "chronic", "plaque", "psoriasis", "C1413682#ent", "<e2>", ")", "."], "h": {"id": "C0030246", "name": "C0030246#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [30, 31]}}
{"token": ["Relative", "bio-availability", "of", "P", "from", "APP", "or", "C1824810#ent", "<e1>", "was", "better", "for", "body", "weight", "gain", "AP", ",", "SSP", "or", "C1705924#ent", "<e2>", ",", "while", "the", "reverse", "was", "true", "for", "bone", "calcification"], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705924", "name": "C1705924#ent", "pos": [19, 20]}}
{"token": ["In", "animals", "without", "SCH32615", ",", "the", "time", "course", "bronchoconstriction", "was", "similar", "for", "NKA", "and", "C1824810#ent", "<e1>", "gamma", ",", "but", "C1705924#ent", "<e2>", "caused", "significantly", "more", "prolonged", "changes", "in", "GL", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705924", "name": "C1705924#ent", "pos": [19, 20]}}
{"token": ["High", "mobility", "group", "box", "1", "C1333908#ent", "<e1>", ")", "regulates", "multiple", "cell", "functions", "including", "transcription", ",", "C1333237#ent", "<e2>", "differentiation", ",", "and", "apoptosis", "."], "h": {"id": "C1333908", "name": "C1333908#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [15, 16]}}
{"token": ["Using", "bilateral", "reverse", "microdialysis", "D1", "and", "C3850099#ent", "<e1>", "SCH23390", ",", "sulpiride", ")", "and", "the", "DA", "uptake", "blocker", "C0028277#ent", "<e2>", "were", "introduced", "into", "NAcc", "while", "measuring", "both", "ingestive", "behavior", "neurochemistry", "."], "h": {"id": "C3850099", "name": "C3850099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028277", "name": "C0028277#ent", "pos": [17, 18]}}
{"token": ["Coadministration", "of", "the", "C3850099#ent", "<e1>", "haloperidol", ",", "and", "the", "DA", "uptake", "inhibitor", ",", "C0028277#ent", "<e2>", ",", "results", "in", "significantly", "more", "DA", "transients", "than", "either", "drug", "alone", "."], "h": {"id": "C3850099", "name": "C3850099#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028277", "name": "C0028277#ent", "pos": [13, 14]}}
{"token": ["Additional", "factors", "are", "probably", "involved", "in", "the", "human", "disease", "genetic", "host", "susceptibility", ",", "C0022806#ent", "<e1>", ",", "repeated", "infections", "and", "repeated", "treatment", ",", "mixed", "infections", "C0019159#ent", "<e2>", ",", "tuberculosis", "and", "typhoid", "."], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [24, 25]}}
{"token": ["Exclusion", "of", "liver", "disease", "other", "causes", "such", "as", "C0241910#ent", "<e1>", "necessary", "for", "diagnosis", "of", "C0015696#ent", "<e2>", "NAFLD", ")", "."], "h": {"id": "C0241910", "name": "C0241910#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015696", "name": "C0015696#ent", "pos": [14, 15]}}
{"token": ["This", "was", "true", "for", "patients", "initially", "treated", "with", "C0025241#ent", "<e1>", "and", "prednisone", "or", "vincristine", ",", "C0085752#ent", "<e2>", ",", "and", "dexamethasone", ",", "as", "well", "as", "patients", "studied", "at", "relapse", "."], "h": {"id": "C0025241", "name": "C0025241#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [15, 16]}}
{"token": ["Gallium", "nitrate", "the", "bisphosphonate", ",", "C0037507#ent", "<e1>", ",", "are", "new", "C0991617#ent", "<e2>", "that", "have", "recently", "become", "available", "for", "treatment", "of", "this", "disorder", "."], "h": {"id": "C0037507", "name": "C0037507#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [10, 11]}}
{"token": ["Although", "many", "patients", "with", "Paget's", "disease", "not", "require", "pharmacologic", "therapy", "calcitonin", "and", "C0037507#ent", "<e1>", "are", "the", "C0991617#ent", "<e2>", "of", "choice", "when", "it", "is", "indicated", "."], "h": {"id": "C0037507", "name": "C0037507#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}}
{"token": ["The", "results", "show", "that", "C0037507#ent", "<e1>", "has", "a", "more", "rapid", "blood", "clearance", "the", "other", "two", "C0991617#ent", "<e2>", ",", "with", "a", "resultant", "improvement", "in", "the", "bone", "to", "soft-tissue", "ratio", "."], "h": {"id": "C0037507", "name": "C0037507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [15, 16]}}
{"token": ["C0015133#ent", "<e1>", "in", "better", "total", "FLI-C", "C0518214#ent", "<e2>", "score", "than", "radiotherapy", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0518214", "name": "C0518214#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "on", "the", "physical", "and", "psychological", "subscales", "the", "C0015133#ent", "<e1>", "group", "had", "a", "significantly", "better", "C0518214#ent", "<e2>", "than", "the", "other", "3", "treatment", "groups", "p", "<", "0.04", ")", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0518214", "name": "C0518214#ent", "pos": [17, 18]}}
{"token": ["Although", "there", "is", "no", "correlation", "between", "tau", "1", "activity", "as", "a", "C3541302#ent", "<e1>", "inhibitor", ",", "a", "qualitative", "relationship", "between", "tau", "2", "C0014175#ent", "<e2>", "or", "exo", ")", "and", "activity", "with", "C3541302#ent", "<e1>", "is", "apparent", "."], "h": {"id": "C3541302", "name": "C3541302#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014175", "name": "C0014175#ent", "pos": [21, 22]}}
{"token": ["At", "study", "end", ",", "among", "patients", "expressing", "a", "preference", ",", "15", "of", "21", "(", "71", "%", ")", "chose", "C0054480#ent", "<e1>", "over", "placebo", "for", "relief", "of", "the", "symptoms", "of", "C0022104#ent", "<e2>"], "h": {"id": "C0054480", "name": "C0054480#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [28, 29]}}
{"token": ["Employing", "rest", "and", "exercise", "first-pass", "radionuclide", "angiography", "and", "3", "months", "after", "surgery", ",", "we", "studied", "patients", "with", "hemodynamically", "stable", "C0519097#ent", "<e1>", "LVA", ")", "undergoing", "both", "coronary", "artery", "bypass", "surgery", "relieve", "C0340288#ent", "<e2>", "elective", "aneurysmectomy", "."], "h": {"id": "C0519097", "name": "C0519097#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [30, 31]}}
{"token": ["C1824351#ent", "<e1>", "and", "C3811667#ent", "<e2>", "also", "exhibit", "the", "same", "pattern", "of", "genetic", "interactions", "mutations", "in", "C1824351#ent", "<e1>", "are", "synthetically", "lethal", "with", "mutations", "in", "BEM2", "and", "MYO2", "but", "not", "SAC6", "."], "h": {"id": "C3811667", "name": "C3811667#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1824351", "name": "C1824351#ent", "pos": [0, 1]}}
{"token": ["We", "propose", "that", "S-", "and", "M-phase", "entries", "mediated", "by", "the", "accumulation", "of", "cyclin", "A", "C1332695#ent", "<e1>", "a", "Pin1-dependent", "stabilization", "of", "Emi1", "during", "C1413737#ent", "<e2>", "."], "h": {"id": "C1332695", "name": "C1332695#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413737", "name": "C1413737#ent", "pos": [22, 23]}}
{"token": ["Similar", "to", "the", "avian", "homolog", ",", "the", "human", "C0063382#ent", "<e1>", "lacks", "a", "long", "open", "reading", "frame", "C3715179#ent", "<e2>", ")", "."], "h": {"id": "C0063382", "name": "C0063382#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3715179", "name": "C3715179#ent", "pos": [16, 17]}}
{"token": ["Brief", "characteristics", "of", "their", "antibacterial", "activity", "experimental", "data", "C0003392#ent", "<e1>", "pefloxacin", ",", "a", "fluoroquinolone", "on", "models", "of", "septicopyemia", "and", "C0025309#ent", "<e2>", "in", "experiments", "with", "mice", "infected", "by", "P.", "aeruginosa", "Staphylococcus", "and", "Klebsiella", "are", "presented", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025309", "name": "C0025309#ent", "pos": [19, 20]}}
{"token": ["The", "evidence", "from", "animal", "and", "human", "experiments", "is", "presented", "that", "brofaromine", "is", "safer", "than", "classical", "C3540022#ent", "<e1>", "respect", "to", "C0026454#ent", "<e2>", "potentiation", "."], "h": {"id": "C3540022", "name": "C3540022#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [19, 20]}}
{"token": ["The", "modified", "glycoprotein", "was", "hydrolysed", "with", "trypsin", "to", "give", "various", "C0030956#ent", "<e1>", ",", "the", "identities", "of", "which", "were", "established", ",", "and", "C0061642#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0061642", "name": "C0061642#ent", "pos": [21, 22]}}
{"token": ["Because", "we", "extensively", "pronase", "digested", "cell", "glycoproteins", "then", "enriched", "for", "glycopeptides", "containing", "small", "amounts", "C0030956#ent", "<e1>", ",", "we", "attribute", "the", "inhibition", "to", "the", "carbohydrate", "portion", "the", "C0061642#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0061642", "name": "C0061642#ent", "pos": [26, 27]}}
{"token": ["Further", ",", "we", "found", "that", "in", "the", "axolotl", ",", "C4285344#ent", "<e1>", "regulates", "the", "expression", "of", "C0174383#ent", "<e2>", "collagenase", "3", "which", "are", "C4285344#ent", "<e1>", "target", "genes", "in", "Xenopus", "."], "h": {"id": "C0174383", "name": "C0174383#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4285344", "name": "C4285344#ent", "pos": [9, 10]}}
{"token": ["The", "results", "suggest", "that", "C0772213#ent", "<e1>", "to", "have", "great", "clinical", "potential", "C0028841#ent", "<e2>"], "h": {"id": "C0772213", "name": "C0772213#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028841", "name": "C0028841#ent", "pos": [11, 12]}}
{"token": ["To", "study", "neuroprotective", "effects", "C0772213#ent", "<e1>", "is", "an", "alpha(1)-adrenoceptor", "antagonist", "used", "as", "an", "C0028841#ent", "<e2>", "to", "other", "alpha(1)-adrenoceptor", "antagonists", ",", "and", "its", "mechanism", "of", "action", "."], "h": {"id": "C0772213", "name": "C0772213#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028841", "name": "C0028841#ent", "pos": [13, 14]}}
{"token": ["However", ",", "in", "contrast", "to", "the", "unstability", "of", "vertebrate", "telomeric", "mononucleosomes", ",", "the", "T.", "thermophila", "C0021345#ent", "<e1>", "were", "stable", "to", "C0025965#ent", "<e2>", "digestion", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025965", "name": "C0025965#ent", "pos": [20, 21]}}
{"token": ["C0021345#ent", "<e1>", "released", "from", "Dictyostelium", "discoideum", "chromatin", "by", "C0025965#ent", "<e2>", "two", "distinctive", "DNA", "sizes", "166", "-", "180", "and", "146", "bp", ")", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025965", "name": "C0025965#ent", "pos": [8, 9]}}
{"token": ["C0021345#ent", "<e1>", "isolated", "from", "C0025965#ent", "<e2>", "stationary", "phase", "chromatin", "the", "yeast", "Saccharomyces", "cerevisiae", "compared", "both", "compositionally", "and", "physiochemically", "with", "those", "from", "chicken", "and", "bovine", "calf"], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025965", "name": "C0025965#ent", "pos": [4, 5]}}
{"token": ["C1420877#ent", "<e1>", "increased", "significantly", "during", "C1417807#ent", "<e2>", "infusion", "."], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [5, 6]}}
{"token": ["Autoregulatory", "phenomena", "may", "counteract", "these", "hemodynamic", "effects", ",", "returning", "CO", "to", "control", "levels", "reducing", "C1420877#ent", "<e1>", "when", "the", "elevations", "in", "plasma", "C1417807#ent", "<e2>", "are", "chronically", "sustained", "."], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [21, 22]}}
{"token": ["Neostigmine", "0.625", "mg", "also", "significantly", "accelerated", "recovery", "after", "C0004234#ent", "<e1>", "and", "was", "comparable", "to", "C0027679#ent", "<e2>", "1.25", "mg", "."], "h": {"id": "C0004234", "name": "C0004234#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027679", "name": "C0027679#ent", "pos": [14, 15]}}
{"token": ["Effective", "C0220884#ent", "<e1>", "concentration", "of", "15", "-", "30", "micrograms/ml", "increased", "cellular", "retinyl", "C0008385#ent", "<e2>", "contents", "."], "h": {"id": "C0220884", "name": "C0220884#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "the", "suppression", "of", "ERK-MAP", "kinase", "activation", "in", "C1307053#ent", "<e1>", "restored", "by", "overexpression", "of", "a", "dominant-negative", "C0812228#ent", "<e2>", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [17, 18]}}
{"token": ["We", "show", "here", ",", "by", "transient", "and", "stable", "transfection", "analyses", "that", "C1412207#ent", "<e1>", "also", "participates", "in", "the", "C0669365#ent", "<e2>", "secretion", "of", "N1", "in", "HEK293", "cells", "TSM1", "neurons", ",", "and", "mouse", "fibroblasts", "."], "h": {"id": "C1412207", "name": "C1412207#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}}
{"token": ["This", "observation", "may", "have", "implications", "for", "functional", "etiological", "differences", "between", "the", "C3898105#ent", "<e1>", "and", "polyarticular", "C3495559#ent", "<e2>", "patients", "."], "h": {"id": "C3898105", "name": "C3898105#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [15, 16]}}
{"token": ["This", "study", "used", "Finnish", "juvenile", "idiopathic", "arthritis", "C3495559#ent", "<e1>", ")", "probands", "with", "C3898105#ent", "<e2>", "and", "rheumatoid", "factor", "RF", ")", "negative", "polyarticular", "subtypes", "of", "C3495559#ent", "<e1>", "to", "further", "define", "the", "genetic", "susceptibility", "C3495559#ent", "<e1>", "."], "h": {"id": "C3898105", "name": "C3898105#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [7, 8]}}
{"token": ["This", "is", "seen", "in", "organ-specific", "autoimmune", "diseases", "as", "rheumatoid", "arthritis", "C1527336#ent", "<e1>", "and", "Hashimoto's", "thyroiditis", "but", "also", "in", "C0005943#ent", "<e2>", "as", "Helicobacter", "pylori-induced", "gastritis"], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [18, 19]}}
{"token": ["Seven", "patients", "suffering", "from", "restless", "legs", "syndrome", "C0035258#ent", "<e1>", ")", "and", "periodic", "movements", "sleep", "(", "C1418866#ent", "<e2>", ")", "were", "investigated", "before", "and", "after", "treatment", "with", "L-Dopa", "."], "h": {"id": "C0035258", "name": "C0035258#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418866", "name": "C1418866#ent", "pos": [15, 16]}}
{"token": ["C0282138#ent", "<e1>", "Cav1.2", "is", "frequency-dependent", "and", "potentiated", "by", "C1413043#ent", "<e2>", "+", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [8, 9]}}
{"token": ["C0022959#ent", "<e1>", "fusions", "of", "the", "C3539630#ent", "<e2>", "and", "PFK2", "promoters", "were", "constructed", "and", "a", "deletion", "analysis", "performed", "."], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539630", "name": "C3539630#ent", "pos": [5, 6]}}
{"token": ["We", "also", "demonstrated", "that", "in", "these", "cells", ",", "C1335877#ent", "<e1>", "activation", "is", "mediated", "through", "JAK1", "and", "C1527617#ent", "<e2>", "tyrosine", "kinases", "."], "h": {"id": "C1335877", "name": "C1335877#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1527617", "name": "C1527617#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "we", "found", "a", "higher", "risk", "for", "C0004943#ent", "<e1>", "the", "MICA", "gene", "46", "kb", "centromeric", "of", "C1415561#ent", "<e2>", ",", "by", "investigation", "of", "GCT", "repetitive", "polymorphism", "within", "exon", "5", "MICA", "."], "h": {"id": "C0004943", "name": "C0004943#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415561", "name": "C1415561#ent", "pos": [17, 18]}}
{"token": ["Hierarchical", "clustering", "gene", "expression", "distinguishes", "the", "three", "cell", "types", "most", "notably", "highlighting", "exceptional", "levels", "of", "expression", "of", "the", "GPCR", "C1423091#ent", "<e1>", "within", "the", "immature", "monocyte-derived", "DC", "MDDC", ")", "C1418864#ent", "<e2>"], "h": {"id": "C1423091", "name": "C1423091#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418864", "name": "C1418864#ent", "pos": [28, 29]}}
{"token": ["Finally", ",", "we", "show", "that", "C1334906#ent", "<e1>", ",", "in", "the", "presence", "of", "NTNR-alpha", ",", "induces", "tyrosine-phosphorylation", "of", "C0813143#ent", "<e2>", ",", "and", "that", "C1334906#ent", "<e1>", ",", "NTNR-alpha", "and", "C0813143#ent", "<e2>", "form", "a", "physical", "complex", "the", "cell", "surface"], "h": {"id": "C0813143", "name": "C0813143#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334906", "name": "C1334906#ent", "pos": [5, 6]}}
{"token": ["The", "absence", "of", "C0813143#ent", "<e1>", "expression", "at", "E14", "suggests", "that", "both", "GDNF", "and", "C1334906#ent", "<e2>", "may", "employ", "an", "additional", ",", "unknown", "receptor", "."], "h": {"id": "C0813143", "name": "C0813143#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334906", "name": "C1334906#ent", "pos": [13, 14]}}
{"token": ["Current", "diagnoses", "for", "neurosurgical", "interventions", "Parkinson's", "disease", "C1414474#ent", "<e1>", "multiple", "sclerosis", "and", "some", "dystonic", "disorders", "as", "C0013423#ent", "<e2>"], "h": {"id": "C1414474", "name": "C1414474#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013423", "name": "C0013423#ent", "pos": [16, 17]}}
{"token": ["RSV", "infections", "associated", "with", "fluid", "accumulation", "in", "the", "respiratory", "tract", "cause", "illnesses", "that", "range", "in", "severity", "from", "rhinitis", ",", "C0149512#ent", "<e1>", ",", "otitis", "media", "and", "bronchitis", "to", "C0006274#ent", "<e2>", "and", "pneumonia", "."], "h": {"id": "C0149512", "name": "C0149512#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0006274", "name": "C0006274#ent", "pos": [27, 28]}}
{"token": ["Mutations", "in", "respiratory", "chain", "proteins", "by", "mtDNA", "result", "in", "phenotypes", "ranging", "from", "exercise", "intolerance", "to", "blindness", ",", "ataxia", ",", "C0393593#ent", "<e1>", ",", "dementia", ",", "and", "C0023264#ent", "<e2>"], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [19, 20]}, "relation": "manifestation_of", "t": {"id": "C0023264", "name": "C0023264#ent", "pos": [25, 26]}}
{"token": ["We", "therefore", "suggest", "that", "the", "C1420221#ent", "<e1>", "further", "investigation", "as", "another", "candidate", "gene", "for", "C0019880#ent", "<e2>", "."], "h": {"id": "C1420221", "name": "C1420221#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "C0376515#ent", "<e1>", "mRNA", "expression", "decreased", "upon", "stimulation", "with", "C1854580#ent", "<e2>", "plus", "IL-2", ",", "whereas", "C1854580#ent", "<e2>", "or", "IL-2", "alone", "did", "not", "affect", "the", "level", "of", "C0376515#ent", "<e1>", "expression", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1854580", "name": "C1854580#ent", "pos": [10, 11]}}
{"token": ["The", "results", "suggest", "that", "C1704960#ent", "<e1>", "may", "not", "permit", "bioconversion", "of", "nicotinamide", "to", "C3536880#ent", "<e2>", "annul", "the", "growth", "inhibition", "induced", "by", "C1704960#ent", "<e1>", "."], "h": {"id": "C1704960", "name": "C1704960#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536880", "name": "C3536880#ent", "pos": [13, 14]}}
{"token": ["Lichenoid", "dermatitis", "like", "C0857751#ent", "<e1>", "graft", "versus", "host", "disease", "C0024141#ent", "<e2>", "is", "based", "on", "a", "primary", "cytotoxic", "reaction", "the", "basal", "epithelial", "cell", "due", "to", "alterations", "in", "its", "antigenic", "make-up", "or", "due", "to", "an", "altered", "immune", "response"], "h": {"id": "C0857751", "name": "C0857751#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [9, 10]}}
{"token": ["Sulglicotide", "(", "C0119279#ent", "<e1>", ")", ",", "a", "polysulfated", "glycopeptide", "with", "C0003216#ent", "<e2>", "and", "cytoprotective", "activities", "was", "able", "to", "stabilize", "lysosomal", "membranes", "in", "vitro", "concentrations", "between", "9", "and", "36", "micrograms/ml", "."], "h": {"id": "C0119279", "name": "C0119279#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003216", "name": "C0003216#ent", "pos": [10, 11]}}
{"token": ["We", "report", "three", "patients", "with", "C0878682#ent", "<e1>", "who", "have", "C0011849#ent", "<e2>", "DM", ")", "and", "impaired", "glucose", "tolerance", "IGT", ")", "as", "well", "as", "neurologic", "symptoms"], "h": {"id": "C0878682", "name": "C0878682#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["The", "C0237795#ent", "<e1>", "response", "to", "L-Glu", "is", "also", "mediated", "by", "C0243046#ent", "<e2>", "but", "its", "physiological", "meaning", "is", "still", "unclear", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [10, 11]}}
{"token": ["This", "study", "demonstrates", "that", "the", "C0237795#ent", "<e1>", "responses", "to", "systemically", "injected", "C0243046#ent", "<e2>", "analogs", "are", "smaller", "in", "AV3V-lesioned", "rats", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", "with", "C1705725#ent", "<e1>", ",", "MSU", "stimulated", "a", "sustained", "and", "time-dependent", "relocalization", "of", "C1705280#ent", "<e2>", "and", "PKCalpha", ",", "but", "not", "of", "RhoA", ",", "to", "the", "membrane", "fraction"], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", "it", "is", "suggested", "that", "OCT1", "and", "C1706340#ent", "<e1>", "polymorphisms", "have", "little", "contribution", "to", "the", "clinical", "efficacy", "C0025598#ent", "<e2>", "."], "h": {"id": "C1706340", "name": "C1706340#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [19, 20]}}
{"token": ["In", "a", "series", "of", "our", "experiments", "using", "C0162576#ent", "<e1>", "we", "discovered", "a", "mechanism", "of", "C0014457#ent", "<e2>", "recruitment", "which", "could", "be", "accelerated", "by", "priming", "with", "ECF-P", "in", "parasite", "infected", "eosinophil", "phlegmon"], "h": {"id": "C0162576", "name": "C0162576#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [14, 15]}}
{"token": ["A", "panel", "of", "mouse", "x", "rat", "hybrids", "was", "used", "to", "localize", "the", "C0079429#ent", "<e1>", "corresponding", "to", "both", "VR-1A", "and", "C1417494#ent", "<e2>", "to", "rat", "chromosome", "1"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417494", "name": "C1417494#ent", "pos": [19, 20]}}
{"token": ["A", "disruption", "of", "the", "SKO1", "C0079429#ent", "<e1>", "causes", "a", "partial", "derepression", "of", "C1417494#ent", "<e2>", ",", "indicating", "that", "SKO1", "is", "a", "negative", "regulator", "of", "the", "SUC2", "gene"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417494", "name": "C1417494#ent", "pos": [12, 13]}}
{"token": ["Alteration", "of", "the", "hypothalamic-pituitary-adrenal", "axis", "be", "more", "prevalent", "than", "suspected", "in", "end-stage", "heart", "failure", "and", "the", "diagnosis", "and", "treatment", "of", "this", "C0039082#ent", "<e1>", "may", "ultimately", "improve", "outcomes", "in", "a", "subgroup", "of", "C0018802#ent", "<e2>", "patients", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [31, 32]}}
{"token": ["Molecular", "analysis", "clarified", "the", "pathogenesis", "of", "a", "host", "of", "C0018939#ent", "<e1>", "including", "hemoglobinopathies", ",", "C0005779#ent", "<e2>", "hypercoaguable", "states", "and", "hematologic", "malignancies"], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [14, 15]}}
{"token": ["C0018939#ent", "<e1>", "toxicity", "was", "manifested", "by", "progressive", "peripheral", "pancytopenia", ",", "bone", "marrow", "aplasia", "C0005779#ent", "<e2>", "."], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [13, 14]}}
{"token": ["Familial", "non-Alzheimer", "degenerative", "dementia", "1", "Dementia", "with", "Lewy", "bodies", "is", "characterized", "by", "Alzheimer", "like", "dementia", ",", "C0233763#ent", "<e1>", "diffuse", "Lewy", "bodies", "are", "formed", "by", "ubiquitinated", "C1420276#ent", "<e2>", "."], "h": {"id": "C0233763", "name": "C0233763#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [25, 26]}}
{"token": ["N-terminal", "peptides", "of", "C3273305#ent", "<e1>", ",", "either", "alone", "or", "fused", "to", "heterologous", "C0086376#ent", "<e2>", ",", "exhibited", "rapid", "degradation", "similar", "to", "wild-type", "C3273305#ent", "<e1>", ",", "thereby", "identifying", "an", "N-terminal", "degron", "."], "h": {"id": "C3273305", "name": "C3273305#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["Hydrogen", "bonding", "between", "Arg151", "and", "the", "ring", "oxygen", "C0033384#ent", "<e1>", "of", "the", "sugar", "ligand", "two", "backbone", "carbonyls", "and", "a", "side", "chain", "C1412100#ent", "<e2>", ",", "and", "similar", "interactions", "in", "the", "lac", "repressor", "be", "anticipated", "."], "h": {"id": "C0033384", "name": "C0033384#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412100", "name": "C1412100#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "inflammation", "changed", "the", "pharmacological", "profile", "these", "contractions", "that", "were", "insensitive", "to", "tetrodotoxin", "but", "sensitive", "to", "atropine", "and", "C0211011#ent", "<e1>", ",", "indicating", "that", "C0149520#ent", "<e2>", "action", "potential", "propagation", "in", "the", "intrinsic", "nerves"], "h": {"id": "C0211011", "name": "C0211011#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0149520", "name": "C0149520#ent", "pos": [25, 26]}}
{"token": ["Finally", ",", "sulfonylureas", ",", "including", "C0061323#ent", "<e1>", ",", "may", "be", "useful", "for", "treating", "and", "preventing", "C0011860#ent", "<e2>", "."], "h": {"id": "C0061323", "name": "C0061323#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [15, 16]}}
{"token": ["ACTH", "values", "in", "the", "absence", "of", "C0014996#ent", "<e1>", "were", "not", "affected", "by", "saralasin", ",", "C0014025#ent", "<e2>", ",", "and", "captopril", "and", "were", "increased", "by", "L", "363714"], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [14, 15]}}
{"token": ["The", "C1136254#ent", "<e1>", "mechanism", "of", "C0211223#ent", "<e2>", "was", "studied", "using", "Pseudomonas", "aeruginosa", "IFO", "3080"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0211223", "name": "C0211223#ent", "pos": [5, 6]}}
{"token": ["Previous", "studies", "have", "shown", "a", "possible", "association", "between", "C3714760#ent", "<e1>", "TD", ")", "and", "C3887685#ent", "<e2>", "CYP2D6", ")", "polymorphisms", ",", "which", "result", "in", "absent", "enzyme", "activity"], "h": {"id": "C3714760", "name": "C3714760#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [13, 14]}}
{"token": ["These", "disorders", "of", "early", "cardiac", "function", "candidate", "genes", "to", "be", "examined", "in", "complex", "human", "C0018799#ent", "<e1>", "including", "arrhythmias", "and", "C0018801#ent", "<e2>"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["C1332666#ent", "<e1>", "is", "involved", "in", "the", "activation", "cascade", "C0010656#ent", "<e2>", "responsible", "for", "apoptosis", "execution", "."], "h": {"id": "C1332666", "name": "C1332666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [8, 9]}}
{"token": ["C0012010#ent", "<e1>", "elevated", "the", "level", "of", "C1336688#ent", "<e2>", "induced", "the", "loss", "of", "single", "chromosomes", ",", "suggesting", "an", "effect", "on", "motor", "proteins"], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336688", "name": "C1336688#ent", "pos": [6, 7]}}
{"token": ["Consistently", ",", "C0004199#ent", "<e1>", "activity", "is", "reduced", "in", "cardiomyocytes", "from", "C1419781#ent", "<e2>", "knockout", "mice"], "h": {"id": "C0004199", "name": "C0004199#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419781", "name": "C1419781#ent", "pos": [10, 11]}}
{"token": ["In", "vitro", "assays", "with", "Escherichia", "coli-derived", "glutathione", "S-transferase", "fusion", "proteins", "autophosphorylation", "of", "C0252902#ent", "<e1>", "and", "PknD", ",", "indicating", "that", "they", "are", "functional", "C0031727#ent", "<e2>", "."], "h": {"id": "C0252902", "name": "C0252902#ent", "pos": [12, 13]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "C0008425#ent", "<e1>", "not", "change", "the", "effects", "of", "BA", "on", "C0079068#ent", "<e2>", "or", "c-jun", "."], "h": {"id": "C0008425", "name": "C0008425#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [12, 13]}}
{"token": ["A", "40-year-old", "male", "who", "had", "a", "previous", "history", "of", "autoimmune", "hemolytic", "anemia", "agranulocytosis", "and", "C0040034#ent", "<e1>", "was", "admitted", "to", "our", "hospital", "because", "of", "C0524909#ent", "<e2>"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [23, 24]}}
{"token": ["We", "present", "the", "case", "of", "a", "woman", "with", "a", "history", "of", "autoimmune", "haemolytic", "anaemia", "C0040034#ent", "<e1>", ",", "and", "common", "variable", "immunodeficiency", "who", "developed", "C0524909#ent", "<e2>"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [23, 24]}}
{"token": ["C0040034#ent", "<e1>", "can", "be", "found", "in", "patients", "with", "C0524909#ent", "<e2>", "to", "hepatitis", "C", "virus", "HCV", ")", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [8, 9]}}
{"token": ["Inhibitors", "of", "p38", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e1>", ",", "but", "not", "p44/42", "MAP", "kinases", "(", "C0600388#ent", "<e2>", ",", "blocked", "the", "proliferation", "induced", "by", "nonconducting", "EAG", "in", "serum-free", "media", "and", "EAG", "increased", "p38", "MAP", "kinase", "activity"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [16, 17]}}
{"token": ["Sj\u00f6gren-Larsson", "syndrome", "SLS", ")", ",", "a", "rare", "autosomal", "disorder", "by", "C0020757#ent", "<e1>", ",", "spastic", "neurological", "disorders", "oligophrenia", ",", "is", "associated", "with", "deficiency", "of", "C0311619#ent", "<e2>", "encoded", "by", "a", "gene", "on", "chromosome", "17q11.2"], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0311619", "name": "C0311619#ent", "pos": [23, 24]}}
{"token": ["From", "the", "comparison", "with", "the", "effects", "of", "C0733398#ent", "<e1>", ",", "yohimbine", "and", "C0076107#ent", "<e2>", ",", "DG-5128", "was", "strongly", "suggested", "to", "stimulate", "the", "glucose-primed", "insulin", "release", "through", "antagonizing", "at", "alpha", "2-adrenoreceptors", "the", "B", "cells"], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0076107", "name": "C0076107#ent", "pos": [12, 13]}}
{"token": ["This", "action", "of", "NE", "was", "blocked", "by", "the", "alpha", "receptor", "antagonist", "C0733398#ent", "<e1>", "and", "the", "specific", "alpha", "1", "receptor", "C0076107#ent", "<e2>", ",", "but", "not", "by", "the", "beta", "receptor", "antagonist", "timolol", "the", "alpha", "2", "receptor", "antagonist", "idazoxan", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0076107", "name": "C0076107#ent", "pos": [19, 20]}}
{"token": ["There", "are", "few", "data", "in", "the", "literature", "suggesting", "that", "endogenous", "prostaglandins", "(", "C0796254#ent", "<e1>", ")", "might", "be", "involved", "in", "the", "pathomechanism", "of", "C0036572#ent", "<e2>", "."], "h": {"id": "C0796254", "name": "C0796254#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [22, 23]}}
{"token": ["Release", "of", "prostaglandins", "(", "C0796254#ent", "<e1>", ")", "from", "brain", "tissue", "increases", "during", "experimentally-induced", "and", "spontaneous", "C0036572#ent", "<e2>", "."], "h": {"id": "C0796254", "name": "C0796254#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [15, 16]}}
{"token": ["The", "derived", "amino", "acid", "sequences", "these", "C0086376#ent", "<e1>", "differ", "from", "human", "C2681594#ent", "<e2>", "in", "the", "number", "of", "consecutive", "glycines", "near", "the", "amino-terminus", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2681594", "name": "C2681594#ent", "pos": [11, 12]}}
{"token": ["Following", "a", "historical", "overview", "the", "evolution", "of", "heparin", "therapy", "include", "C0019139#ent", "<e1>", "LMWH", ")", ",", "the", "pharmacokinetic", "properties", "of", "C0206460#ent", "<e2>", "are", "described", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [10, 11]}, "relation": "structural_class_of", "t": {"id": "C0206460", "name": "C0206460#ent", "pos": [19, 20]}}
{"token": ["There", "was", "no", "difference", "in", "the", "level", "of", "C0000503#ent", "<e1>", "between", "gestational", "and", "C0011854#ent", "<e2>", "the", "latter", "showed", "a", "significantly", "higher", "blood", "glucose", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C0000503", "name": "C0000503#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "cellular", "levels", "alpha-MSH", "and", "C1337111#ent", "<e1>", "were", "decreased", "during", "long-term", "treatment", "of", "cells", "with", "an", "C0078989#ent", "<e2>", "pepstatin", "A", "and", "with", "the", "cysteine", "protease", "inhibitor", "E64c", "."], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0078989", "name": "C0078989#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "demonstrate", "the", "parallel", "regulation", "of", "cellular", "levels", "alpha-MSH", "and", "C1337111#ent", "<e1>", "during", "their", "cosecretion", ",", "which", "may", "involve", "C0078989#ent", "<e2>", "and", "cysteine", "proteases", "the", "metabolism", "of", "these", "peptide", "hormones"], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0078989", "name": "C0078989#ent", "pos": [20, 21]}}
{"token": ["Standard", "of", "care", "highly", "active", "C0024143#ent", "<e1>", "children", "remains", "C0010583#ent", "<e2>", "although", "preliminary", "experience", "suggests", "that", "the", "addition", "of", "rituximab", "may", "allow", "for", "remission", "induction", "with", "a", "reduction", "in", "cumulative", "cyclophosphamide", "dose", "."], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [9, 10]}}
{"token": ["To", "evaluate", "the", "use", "of", "mycophenolate", "mofetil", "MMF", ")", "in", "C0024143#ent", "<e1>", "LN", ")", "patients", "with", "prior", "failure", "to", "intravenous", "C0010583#ent", "<e2>", "over", "a", "12-month", "follow-up", "."], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [20, 21]}}
{"token": ["We", "have", "developed", "a", "decision", "analysis", "from", "a", "societal", "perspective", "to", "evaluate", "the", "costs", "and", "consequences", "of", "the", "treatment", "of", "ophthalmic", "inflammatory", "conditions", "two", "potent", "C0304604#ent", "<e1>", "prednisolone", "and", "C0140594#ent", "<e2>", "."], "h": {"id": "C0304604", "name": "C0304604#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0140594", "name": "C0140594#ent", "pos": [29, 30]}}
{"token": ["Since", "these", "activities", "are", "common", "to", "C1335223#ent", "<e1>", "and", "C1705526#ent", "<e2>", ",", "we", "tested", "for", "a", "functional", "interaction", "between", "these", "two", "proteins", "by", "investigating", "possible", "effects", "of", "C1335223#ent", "<e1>", "on", "the", "transcriptional", "activator", "function", "C1705526#ent", "<e2>", "."], "h": {"id": "C1335223", "name": "C1335223#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [9, 10]}}
{"token": ["In", "the", "present", "study", ",", "we", "showed", "that", "C1335223#ent", "<e1>", "acted", "synergistically", "with", "either", "C1705526#ent", "<e2>", "or", "a", "histone", "deacetylase", "inhibitor", "trichostatin", "A", "to", "enhance", "p21(WAF1/Cip1", ")", "promoter", "activity"], "h": {"id": "C1335223", "name": "C1335223#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [14, 15]}}
{"token": ["Anaesthetists", "should", "always", "consider", "C0026896#ent", "<e1>", "cases", "of", "C3831153#ent", "<e2>", "presenting", "with", "neuromuscular", "features", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [8, 9]}}
{"token": ["Intravenous", "edrophonium", "chloride", "stopped", "a", "sustained", "high", "frequency", "abduction", "nystagmus", "supporting", "a", "diagnosis", "of", "C0026896#ent", "<e1>", "a", "patient", "with", "C3831153#ent", "<e2>", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [19, 20]}}
{"token": ["Finally", ",", "C1427908#ent", "<e1>", "interacted", "with", "C1418401#ent", "<e2>", ",", "TNF-alpha", ",", "LTA", ",", "and", "C4", "."], "h": {"id": "C1427908", "name": "C1427908#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [6, 7]}}
{"token": ["We", "could", ",", "therefore", ",", "conclude", "from", "these", "observations", "that", "C0700579#ent", "<e1>", "usual", "clinical", "dosage", "dose", "exert", "unfavourable", "effects", "on", "glucose", "tolerance", "insulin", "secretion", "the", "C0362046#ent", "<e2>", "patients", "."], "h": {"id": "C0700579", "name": "C0700579#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [25, 26]}}
{"token": ["It", "also", "hydrolyzed", "p-nitrophenyl-N-acetyl-beta-glucosaminide", ",", "but", "not", "C0873033#ent", "<e1>", ";", "in", "contrast", ",", "Drosophila", "C1333365#ent", "<e2>", "and", "HEXO2", "expressed", "in", "Pichia", "cleaved", "both", "these", "substrates", "but", "not", "N-glycans", "."], "h": {"id": "C0873033", "name": "C0873033#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333365", "name": "C1333365#ent", "pos": [14, 15]}}
{"token": ["Transient", "expression", "of", "the", "protein", "in", "COS", "cells", "which", "were", "able", "to", "isoprenylate", "the", "C1420626#ent", "<e1>", "product", "of", "transfected", "C0079471#ent", "<e2>", ",", "also", "failed", "to", "demonstrate", "isoprenylation", "of", "Gi", "alpha", "1"], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [19, 20]}}
{"token": ["Lovastatin", "specifically", "recruits", "the", "forkhead", "box", "FoxO3a", "transcription", "factor", "the", "C1420626#ent", "<e1>", "promoter", ",", "mediating", "transcriptional", "transactivation", "the", "C0079471#ent", "<e2>", "analyzed", "in", "isolated", "primary", "cardiomyocytes", "."], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [18, 19]}}
{"token": ["It", "is", "described", "a", "muscular", "dystony", "case", "of", "manganism", ",", "treated", "with", "results", "in", "two", "following", "phases", "with", "haloperidol", "and", "C0012010#ent", "<e1>", "and", "then", "with", "L-Dopa", "+", "C0005014#ent", "<e2>", "."], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0005014", "name": "C0005014#ent", "pos": [27, 28]}}
{"token": ["Breakthrough", "fungemia", "empiric", "therapy", "with", "C0016277#ent", "<e1>", "was", "also", "observed", "more", "frequently", "in", "patients", "with", "persistent", "C0085082#ent", "<e2>", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0085082", "name": "C0085082#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "to", "C0596621#ent", "<e1>", "well-established", "assays", "of", "cell", "death", "as", "C0027203#ent", "<e2>", "release", "and", "cell", "viability", "performed", "to", "obtain", "information", "about", "the", "number", "of", "living", "cells"], "h": {"id": "C0596621", "name": "C0596621#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["The", "study", "aimed", "to", "explore", "whether", "the", "C2348924#ent", "<e1>", "polymorphisms", "are", "associated", "with", "outcomes", "of", "C0019163#ent", "<e2>", "infection", "in", "the", "Chinese", "Han", "population", "."], "h": {"id": "C2348924", "name": "C2348924#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [15, 16]}}
{"token": ["Fortunately", ",", "the", "vast", "majority", "of", "cases", "of", "C0006840#ent", "<e1>", "not", "life-threatening", "and", "readily", "respond", "to", "appropriately", "administered", "C0003392#ent", "<e2>"], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [18, 19]}}
{"token": ["In", "addition", "to", "the", "relatively", "common", "inherited", "C0596848#ent", "<e1>", "familial", "hypercholesterolaemia", "familial", "combined", "hyperlipidaemia", "an", "important", "dominantly", "inherited", "lipid", "variable", "to", "coronary", "risk", "C1439335#ent", "<e2>"], "h": {"id": "C0596848", "name": "C0596848#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1439335", "name": "C1439335#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "a", "method", "for", "detection", "of", "specific", "RNA", "targets", "in", "cultured", "cells", "the", "electron", "microscopic", "C1705457#ent", "<e1>", ")", "level", "using", "pre-embedding", "in", "situ", "hybridization", "C0020498#ent", "<e2>", ")", "."], "h": {"id": "C1705457", "name": "C1705457#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020498", "name": "C0020498#ent", "pos": [25, 26]}}
{"token": ["The", "latter", "will", "be", "used", "to", "propose", "a", "novel", "approach", "to", "the", "quantitative", "analysis", "C0003286#ent", "<e1>", "in", "serum", "using", "C0019469#ent", "<e2>", "as", "internal", "standard"], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0019469", "name": "C0019469#ent", "pos": [19, 20]}}
{"token": ["The", "C1335528#ent", "<e1>", "sequenced", "from", "plasma-derived", "virus", "from", "116", "C1947941#ent", "<e2>", "inhibitor-na\u00efve", "patients", "."], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [9, 10]}}
{"token": ["Studies", "with", "HSV-1", "strains", "harbour", "mutations", "in", "the", "C1335528#ent", "<e1>", "demonstrated", "that", "the", "C1947941#ent", "<e2>", "is", "essential", "for", "DNA", "packaging", "virus", "maturation"], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "C0237795#ent", "<e1>", "responses", "induced", "by", "norepinephrine", "were", "not", "significantly", "affected", "by", "C3539565#ent", "<e2>", "administration", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539565", "name": "C3539565#ent", "pos": [14, 15]}}
{"token": ["A", "case", "of", "trichomycosis", "pubis", "a", "bacterial", "disorder", "can", "easily", "be", "mistaken", "for", "several", "C0026946#ent", "<e1>", "responded", "to", "application", "of", "C0068367#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0068367", "name": "C0068367#ent", "pos": [20, 21]}}
{"token": ["In", "mice", ",", "targeting", "of", "GPVI", "with", "the", "monoclonal", "antibody", "induces", "depletion", "of", "the", "receptor", "from", "circulating", "platelets", ",", "resulting", "in", "abolished", "C0009325#ent", "<e1>", "responses", "and", "long-lasting", "C0016018#ent", "<e2>"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [27, 28]}}
{"token": ["One", ",", "POX4", ",", "encodes", "PXP-4", ",", "which", "is", "the", "most", "abundant", "polypeptide", "in", "cells", "grown", "on", "C0028928#ent", "<e1>", "and", "the", "other", ",", "POX5", ",", "is", "the", "C0079429#ent", "<e2>", "for", "PXP-5", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [27, 28]}}
{"token": ["Nuclear", "transcription", "experiments", "showed", "that", "C0028928#ent", "<e1>", "and", "clofibrate", "stimulated", "the", "transcription", "rate", "of", "the", "C0079429#ent", "<e2>", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["The", "C1414323#ent", "<e1>", "eIF-4A", "is", "an", "C0101555#ent", "<e2>", "RNA", "helicase", "in", "ribosome", "attachment", "to", "the", "5", "'", "end", "of", "mRNAs", "."], "h": {"id": "C1414323", "name": "C1414323#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [6, 7]}}
{"token": ["In", "patients", "who", "are", "known", "to", "have", "autoimmune", "diseases", "who", "present", "with", "C0011168#ent", "<e1>", ",", "features", "of", "C0026896#ent", "<e2>", "be", "specifically", "sought", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [17, 18]}}
{"token": ["The", "serpins", "we", "analyzed", "were", "protease", "nexin", "I", "C1418552#ent", "<e1>", ")", ",", "PA", "inhibitor", "1", "PAI-1", ",", "and", "the", "C0618743#ent", "<e2>", "KBP", ")", "."], "h": {"id": "C1418552", "name": "C1418552#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [19, 20]}}
{"token": ["C0021236#ent", "<e1>", ",", "urease", ",", "and", "C1417932#ent", "<e2>", "tested", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [6, 7]}}
{"token": ["The", "strains", "were", "C0021236#ent", "<e1>", ",", "urease", ",", "and", "C1417932#ent", "<e2>", "negative", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [9, 10]}}
{"token": ["We", "propose", "a", "new", "biotype", "(", "IV", ")", "of", "H.", "parainfluenzae", "accommodate", "strains", "that", "are", "C0021236#ent", "<e1>", ",", "urease", "and", "C1417932#ent", "<e2>", "positive", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "acute", "exacerbations", "C0524909#ent", "<e1>", "present", "as", "an", "C0267797#ent", "<e2>", "on", "the", "chronic", "carrier", "state"], "h": {"id": "C0524909", "name": "C0524909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0267797", "name": "C0267797#ent", "pos": [9, 10]}}
{"token": ["Homocysteine", "has", "associations", "with", "both", "C0035078#ent", "<e1>", "vascular", "complications", "and", "its", "status", "is", "therefore", "of", "interest", "in", "C0002895#ent", "<e2>", "SCD", ")", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [17, 18]}}
{"token": ["Ten", "children", "with", "C0035078#ent", "<e1>", "three", "with", "C0002895#ent", "<e2>", "normal", "urine", "calcium", "concentration", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [7, 8]}}
{"token": ["In", "contrast", ",", "C2697944#ent", "<e1>", "did", "not", "affect", "expression", "of", "fibronectin", ",", "whereas", "collagen", "type", "I", "C1412792#ent", "<e2>", "expression", "decreased", "only", "after", "long", "incubations", "high", ",", "toxic", "C2697944#ent", "<e1>", "concentrations", "."], "h": {"id": "C1412792", "name": "C1412792#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2697944", "name": "C2697944#ent", "pos": [3, 4]}}
{"token": ["The", "single", "patient", "who", "did", "not", "respond", "to", "C0010592#ent", "<e1>", "developed", "progressive", "C0085605#ent", "<e2>", "underwent", "orthotopic", "liver", "transplantation", "and", "subsequently", "died", "of", "disseminated", "cytomegalovirus", "infection"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [12, 13]}}
{"token": ["In", "acute", "hepatic", "dysfunction", "discontinued", "C0010592#ent", "<e1>", "(", "CsA", ")", "to", "prevent", "irreversible", "fulminant", "C0085605#ent", "<e2>", "the", "normalization", "of", "liver", "function"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [14, 15]}}
{"token": ["C0038597#ent", "<e1>", "esters", "of", "(1S,5S,6S)-1", ",", "while", "C0008385#ent", "<e2>", "esters", "of", "(1R,5R,6R)-1", ",", "consistent", "with", "approximately", "mirror-image", "arrangement", "of", "the", "active", "sites", "subtilisins", "and", "lipases/esterases", "."], "h": {"id": "C0038597", "name": "C0038597#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [7, 8]}}
{"token": ["C3165062#ent", "<e1>", "CACS", ")", "is", "a", "rare", "entity", "of", "C0853812#ent", "<e2>", "secondary", "to", "inadequate", "blood", "supply", "the", "intestine", ",", "resulting", "in", "weight", "loss", "of", "postprandial", "abdominal", "pain"], "h": {"id": "C3165062", "name": "C3165062#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0853812", "name": "C0853812#ent", "pos": [9, 10]}}
{"token": ["Several", "chemical", "classes", "small", "molecule", "inhibitors", "C3539637#ent", "<e1>", "have", "been", "synthesized", ",", "including", "small", "chain", "fatty", "acids", "C1997166#ent", "<e2>", ",", "hydroxamic", "acids", "hybrid", "molecules"], "h": {"id": "C3539637", "name": "C3539637#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1997166", "name": "C1997166#ent", "pos": [17, 18]}}
{"token": ["Cross-species", "transfers", "of", "pathogens", "(", "C0043528#ent", "<e1>", ")", "cause", "some", "of", "the", "most", "virulent", "diseases", "including", "C0003175#ent", "<e2>", ",", "hantavirus", "and", "Q", "fever"], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0003175", "name": "C0003175#ent", "pos": [16, 17]}}
{"token": ["On", "the", "other", "hand", ",", "C0012582#ent", "<e1>", "(", "0.1", "-", "-1", "microgram", ")", "and", "C0019471#ent", "<e2>", "(", "0.1", "-", "-1", "microgram", ")", "shifted", "the", "curve", "to", "the", "left", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019471", "name": "C0019471#ent", "pos": [14, 15]}}
{"token": ["The", "vascular", "enzyme", "inhibited", "by", "C0012582#ent", "<e1>", "and", "trapymine", "in", "a", "competitive", "manner", ",", "C0019471#ent", "<e2>", "and", "lidoflazine", "are", "without", "any", "effect", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019471", "name": "C0019471#ent", "pos": [14, 15]}}
{"token": ["Congenital", "Adrenal", "Hyperplasia", "C0520463#ent", "<e1>", ")", "is", "caused", "by", "C0010308#ent", "<e2>", "the", "enzyme", "21", "hydroxylase", "(", "21-OHD", ")", "in", "the", "cortisol", "synthesis", "pathway"], "h": {"id": "C0520463", "name": "C0520463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010308", "name": "C0010308#ent", "pos": [9, 10]}}
{"token": ["Three", "types", "of", "poisons", "for", "energy", "systems", "act", "primarily", "on", "respiration", ",", "on", "ATP", "formation", "and", "as", "C1421313#ent", "<e1>", "(", "'", "proton", "conducting", "'", ")", "C0035064#ent", "<e2>", "are", "considered", "."], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [25, 26]}}
{"token": ["Another", "group", "of", "quinoproteins", ",", "consisting", "of", "C0002507#ent", "<e1>", "has", "a", "protein", "chain", "one", "of", "the", "following", "C0301713#ent", "<e2>", "6-hydroxy-phenylalanine-3,4-dione", "(", "TPQ", ")", "or", "4-(2'-tryptophyl)-tryptophan-6,7-dione", "(", "TTQ", ")", "."], "h": {"id": "C0002507", "name": "C0002507#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0301713", "name": "C0301713#ent", "pos": [17, 18]}}
{"token": ["The", "C1422161#ent", "<e1>", "to", "the", "processing", "of", "both", "C0242853#ent", "<e2>", "a-factor", "."], "h": {"id": "C1422161", "name": "C1422161#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [8, 9]}}
{"token": ["In", "MEFs", "lacking", "C1422161#ent", "<e1>", "or", "Icmt", ",", "farnesylated", "C0242853#ent", "<e2>", "mislocalized", "."], "h": {"id": "C1422161", "name": "C1422161#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [9, 10]}}
{"token": ["Mn", "content", "and", "C1705937#ent", "<e1>", "and", "SDH", "activities", "were", "determined", "in", "C1412726#ent", "<e2>", "from", "control", "and", "adrenalectomized", "(", "ADX", ")", "obese", "mice", "and", "from", "control", "and", "corticosterone-supplemented", "lean", "mice", "."], "h": {"id": "C1705937", "name": "C1705937#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [11, 12]}}
{"token": ["SGP", "and", "C0017668#ent", "<e1>", "were", "isolated", "from", "fresh", "egg", "yolk", "treatment", "with", "C0070570#ent", "<e2>", ",", "gel", "filtration", "successive", "chromatographies", "on", "columns", "of", "anion-", "and", "cation-exchangers", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0070570", "name": "C0070570#ent", "pos": [12, 13]}}
{"token": ["Metabolism", "of", "[U-13C]aspartate", "in", "cultured", "astrocytes", "and", "the", "effects", "of", "inhibitors", "of", "malic", "enzyme", "C0031644#ent", "<e1>", "hydroxymalonate", "and", "C0047539#ent", "<e2>", "respectively", ")", "were", "studied", "using", "13C", "nuclear", "magnetic", "resonance", "NMR", ")", "spectroscopy", "."], "h": {"id": "C0031644", "name": "C0031644#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0047539", "name": "C0047539#ent", "pos": [18, 19]}}
{"token": ["Both", "the", "ATP-", "and", "ADP-dependent", "decarboxylation", "of", "oxalacetate", "and", "the", "carboxylation", "activity", "of", "C0031644#ent", "<e1>", "inhibited", "by", "C0047539#ent", "<e2>", "phosphoenolpyruvate", "carboxylase", "ribulose-1,5-bisphosphate", "carboxylase", "not", "inhibited", "."], "h": {"id": "C0031644", "name": "C0031644#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0047539", "name": "C0047539#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "abnormal", "DNA", "methylation", "the", "pathological", "functional", "imprinting", "of", "certain", "human", "genes", "on", "chromosome", "11p15.5", "Wilms'", "tumors", "in", "the", "C0004903#ent", "<e1>", "on", "chromosome", "15q11", "-", "13", "in", "the", "Prader-Willi", "and", "C0162635#ent", "<e2>"], "h": {"id": "C0004903", "name": "C0004903#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0162635", "name": "C0162635#ent", "pos": [31, 32]}}
{"token": ["The", "results", "suggested", "that", "EGF", "activated", "C1418858#ent", "<e1>", "and", "PP2A", "in", "DC-3F/AD", "X", "cells", "and", "that", "C1418520#ent", "<e2>", "was", "a", "substrate", "for", "the", "phosphatases", "."], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418520", "name": "C1418520#ent", "pos": [16, 17]}}
{"token": ["Enzyme", "incubated", "with", "C3273549#ent", "<e1>", "before", "addition", "of", "C1161331#ent", "<e2>", "was", "stimulated", "by", "dextran", "primer", "and", ",", "conversely", ",", "enzyme", "treated", "with", "dextran", "was", "stimulated", "by", "addition", "of", "C3273549#ent", "<e1>", "with", "the", "sucrose", "substrate"], "h": {"id": "C3273549", "name": "C3273549#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [8, 9]}}
{"token": ["We", "retrospectively", "analyzed", "the", "records", "of", "1,113", "patients", "affected", "with", "optic", "neuritis", "ON", ")", ",", "C0015397#ent", "<e1>", "suspected", "C3887709#ent", "<e2>", "or", "idiopathic", "intracranial", "hypertension", "suspected", "C3887709#ent", "<e2>", "IIH", ")", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C3887709", "name": "C3887709#ent", "pos": [18, 19]}}
{"token": ["C1532737#ent", "<e1>", "Vytorin", ")", "is", "a", "cholesterol-lowering", "therapy", "inhibits", "the", "intestinal", "absorption", "C1142985#ent", "<e2>", ")", "and", "synthesis", "(", "simvastatin", ")", "of", "cholesterol", "."], "h": {"id": "C1532737", "name": "C1532737#ent", "pos": [0, 1]}, "relation": "has_constitutional_part", "t": {"id": "C1142985", "name": "C1142985#ent", "pos": [12, 13]}}
{"token": ["The", "C0030016#ent", "<e1>", "of", "the", "bacterial", "and", "C0171406#ent", "<e2>", "similarly", "and", "strongly", "pH", "dependent", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [7, 8]}}
{"token": ["This", "study", "aims", "to", "determine", "whether", "individuals", "with", "a", "C1705792#ent", "<e1>", "susceptible", "to", "C4053796#ent", "<e2>"], "h": {"id": "C1705792", "name": "C1705792#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4053796", "name": "C4053796#ent", "pos": [13, 14]}}
{"token": ["On", "C0003940#ent", "<e1>", "activity", "was", "restored", "to", "normal", "whereas", "C0003940#ent", "<e1>", "not", "normalised", "."], "h": {"id": "C0003940", "name": "C0003940#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003940", "name": "C0003940#ent", "pos": [1, 2]}}
{"token": ["Under", "these", "conditions", "C0003940#ent", "<e1>", "be", "assayed", "without", "interference", "from", "the", "other", "C0003940#ent", "<e1>", "enzymes", "present", "and", "is", "useful", "as", "a", "marker", "for", "the", "endoplasmic", "reticulum", "cell-fractionation", "studies", "."], "h": {"id": "C0003940", "name": "C0003940#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003940", "name": "C0003940#ent", "pos": [3, 4]}}
{"token": ["Furthermore", ",", "lupus-prone", "mice", "immunized", "with", "this", "C1511664#ent", "<e1>", "had", "higher", "autoantibody", "titers", "as", "well", "as", "more", "severe", "C0031065#ent", "<e2>", "."], "h": {"id": "C1511664", "name": "C1511664#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031065", "name": "C0031065#ent", "pos": [18, 19]}}
{"token": ["Some", "investigators", "use", "it", "in", "the", "treatment", "of", "C0038220#ent", "<e1>", "in", "epilepsy", "surgery", "have", "concluded", "that", "C0033487#ent", "<e2>", "has", "an", "anticonvulsant", "effect"], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [16, 17]}}
{"token": ["Oral", "provocation", "tests", "the", "relation", "between", "long-term", "oral", "use", "of", "C0025859#ent", "<e1>", "and", "development", "of", "psoriasiform", "and/or", "C0013595#ent", "<e2>", "3", "patients", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [17, 18]}}
{"token": ["The", "deduced", "amino", "acid", "sequence", "to", "be", "very", "different", "from", "those", "of", "published", "Aspergillus", "niger", "C0031853#ent", "<e1>", ";", "however", ",", "an", "C1334043#ent", "<e2>", "33", "amino", "acids", "detected", "."], "h": {"id": "C0031853", "name": "C0031853#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "we", "determined", "whether", "suberoylanilide", "hydroxamic", "acid", "SAHA", ")", ",", "a", "C1512474#ent", "<e1>", "1", ")", "inhibits", "inflammatory", "mediator", "production", "in", "vitro", "2", ")", "modulates", "C0024138#ent", "<e2>", "progression", "in", "vivo"], "h": {"id": "C1512474", "name": "C1512474#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [27, 28]}}
{"token": ["Twenty-six", "patients", "with", "oxazaphosphorine-induced", "hematuria", "received", "additional", "C0010583#ent", "<e1>", "or", "ifosfamide", "with", "C0000294#ent", "<e2>", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000294", "name": "C0000294#ent", "pos": [12, 13]}}
{"token": ["C2349086#ent", "<e1>", "induced", "significant", "preservation", "of", "hippocampal", "neurons", ",", "suggesting", "that", "C2349086#ent", "<e1>", "may", "play", "a", "neuroprotective", "role", "C0038220#ent", "<e1>"], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [18, 19]}}
{"token": ["Affinity", "of", "C3811118#ent", "<e1>", "to", "the", "metal", "ions", "in", "C1705077#ent", "<e2>", "is", "higher", "than", "that", "of", "FII", "because", "C3811118#ent", "<e1>", "has", "15", "surface", "histidines", "and", "FII", "has", "5", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705077", "name": "C1705077#ent", "pos": [9, 10]}}
{"token": ["Approval", "of", "two", "C3539119#ent", "<e1>", "pravastatin", "and", "C0074554#ent", "<e2>", ",", "by", "the", "FDA", "gives", "physicians", "the", "additional", "flexibility", "of", "employing", "a", "single", "or", "a", "combination", "drug", "therapy", "optimal", "control", "of", "dyslipidemia", "."], "h": {"id": "C3539119", "name": "C3539119#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0074554", "name": "C0074554#ent", "pos": [7, 8]}}
{"token": ["The", "influence", "of", "key", "agents", "(", "C0001964#ent", "<e1>", "and", "cholesterol", ")", "was", "also", "examined", "using", "C1414805#ent", "<e2>", ",", "and", "backcalculated", "viscosity", "change", "from", "FCVJ", "and", "C1414805#ent", "<e2>", "was", "correlated", "."], "h": {"id": "C0001964", "name": "C0001964#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414805", "name": "C1414805#ent", "pos": [15, 16]}}
{"token": ["C1418544#ent", "<e1>", "activity", "of", "these", "inhibitors", "was", "resistant", "to", "heat", "and", "C0037506#ent", "<e2>", "but", "was", "lost", "after", "reduction", "of", "disulfide", "bonds"], "h": {"id": "C1418544", "name": "C1418544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [11, 12]}}
{"token": ["The", "purification", "of", "the", "C0036323#ent", "<e1>", "preparative", "isoelectric", "and", "gel", "filtration", "that", "C0030940#ent", "<e2>", "to", "hydrolyze", "the", "collagenase", "substrates", "Azocoll", "and", "Z-Gly-Pro-Leu-Gly-Pro", "are", "able", "to", "significantly", "enhance", "eosinophil", "effector", "functions", "."], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [12, 13]}}
{"token": ["This", "study", "compared", "absolute", "myocardial", "blood", "flow", "MBF", ")", "and", "myocardial", "flow", "reserve", "index", "MFR", ")", "with", "C1705556#ent", "<e1>", "and", "dipyridamole", "(", "DIP", ")", "in", "patients", "with", "C0010068#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [27, 28]}}
{"token": ["Although", "LVH", "is", "not", "part", "of", "C1705556#ent", "<e1>", "risk", "assessment", "its", "presence", "as", "defined", "by", "echocardiography", "increases", "C0010068#ent", "<e2>", "risk", "six-", "to", "eightfold", "in", "both", "men", "and", "women", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [17, 18]}}
{"token": ["For", "alpha-amino", "protection", "in", "amino", "acids", "t-butoxycarbonyl", "(", "C1826625#ent", "<e1>", ")", "group", "was", "employed", "for", "17O", "labeled", "C1418457#ent", "<e2>"], "h": {"id": "C1826625", "name": "C1826625#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418457", "name": "C1418457#ent", "pos": [17, 18]}}
{"token": ["C0912403#ent", "<e1>", "a", "lysosomal", ",", "C1332808#ent", "<e2>"], "h": {"id": "C0912403", "name": "C0912403#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332808", "name": "C1332808#ent", "pos": [5, 6]}}
{"token": ["The", "development", "of", "histological", "lesions", "the", "C0268731#ent", "<e1>", "IgG", ",", "IgM", "and", "C3", "were", "suppressed", "by", "C0360556#ent", "<e2>", "treatment", "from", "5", "to", "10", "months", "of", "age", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0360556", "name": "C0360556#ent", "pos": [16, 17]}}
{"token": ["The", "Rickettsia", "prowazekii", "sigma", "factor", "C3889446#ent", "<e1>", ",", "purified", ",", "and", "used", "to", "reconstitute", "RNA", "polymerase", "C0282109#ent", "<e2>", "species", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0282109", "name": "C0282109#ent", "pos": [16, 17]}}
{"token": ["Histological", "examination", "that", "40", "lambs", "(", "83", "per", "cent", ")", "had", "C0027726#ent", "<e1>", ",", "while", "the", "rest", "had", "toxic", "tubular", "necrosis", "C0027707#ent", "<e2>", "tubular", "damage", "associated", "with", "oxalate", "crystal", "deposits", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027707", "name": "C0027707#ent", "pos": [21, 22]}}
{"token": ["Untreated", "rats", "developed", "massive", "C0027726#ent", "<e1>", "intense", "cell", "proliferation", "glomerular", "and", "C0027707#ent", "<e2>"], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027707", "name": "C0027707#ent", "pos": [11, 12]}}
{"token": ["Mice", "lacking", "C2981728#ent", "<e1>", "show", "increased", "susceptibility", "to", "pathogens", "and", "diminished", "C0078956#ent", "<e2>", "and", "B-cell", "function"], "h": {"id": "C2981728", "name": "C2981728#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [11, 12]}}
{"token": ["Only", "plants", "with", "moderate", "C1826797#ent", "<e1>", "over-expression", "were", "obtained", ",", "indicating", "that", "this", "C0014442#ent", "<e2>", "could", "be", "toxic", "at", "high", "levels"], "h": {"id": "C1826797", "name": "C1826797#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["C1419822#ent", "<e1>", "delineates", "specific", "epigenetic", "modifications", "target", "gene", "loci", "directly", "upregulating", "C1417405#ent", "<e2>", "downregulating", "tumour-suppressor", "genes"], "h": {"id": "C1419822", "name": "C1419822#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417405", "name": "C1417405#ent", "pos": [11, 12]}}
{"token": ["By", "analogy", "to", "other", "C0031727#ent", "<e1>", ",", "it", "has", "been", "postulated", "that", "the", "catalytic", "mechanism", "C1418508#ent", "<e2>", "a", "hinge", "bending", "domain", "motion", "that", "brings", "the", "substrates", "together", "to", "allow", "phosphoryl", "transfer"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418508", "name": "C1418508#ent", "pos": [15, 16]}}
{"token": ["C1847843#ent", "<e1>", "an", "autosomal", "dominant", "disorder", "by", "defective", "smooth", "pursuit", "gaze-evoked", "nystagmus", "ataxia", ",", "and", "C0042571#ent", "<e2>", "."], "h": {"id": "C1847843", "name": "C1847843#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0042571", "name": "C0042571#ent", "pos": [15, 16]}}
{"token": ["Arginine", "or", "C0019877#ent", "<e1>", ",", "and", "to", "a", "smaller", "extent", "some", "other", "amino", "acids", "C0220833#ent", "<e2>", ",", "protected", "the", "enzyme", "from", "cold-inactivation", "."], "h": {"id": "C0019877", "name": "C0019877#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220833", "name": "C0220833#ent", "pos": [14, 15]}}
{"token": ["C1334103#ent", "<e1>", "diagnosed", "in", "seven", "patients", "with", "C0020550#ent", "<e2>", "and", "in", "two", "controls", ",", "with", "no", "statistically", "significant", "between", "the", "groups", "(", "Fisher's", "exact", "test", "p", "=", "0.1212", ")", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [7, 8]}}
{"token": ["All", "combinations", "between", "ularitide", "C0000975#ent", "<e1>", "and", "isoproterenol", "hemisulfate", ",", "C0002575#ent", "<e2>", ",", "or", "zaprinast", "respectively", "relaxed", "the", "tracheas", "irreversibly", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [10, 11]}}
{"token": ["In", "order", "to", "elucidate", "the", "mechanism", "of", "substrate", "recognition", "C1426211#ent", "<e1>", ",", "we", "chemically", "synthesized", "variety", "of", "C0031684#ent", "<e2>", "analogs", "and", "carried", "out", "kinetic", "analysis", "them", "as", "C1426211#ent", "<e1>", "substrates", "."], "h": {"id": "C0031684", "name": "C0031684#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1426211", "name": "C1426211#ent", "pos": [9, 10]}}
{"token": ["Crigler-Najjar", "syndrome", "type", "I", "CN-I", ")", "is", "an", "autosomal", "recessive", "condition", "characterized", "by", "severe", "unconjugated", "hyperbilirubinemia", "caused", "by", "the", "lack", "of", "C3812292#ent", "<e1>", ")", "activity", "in", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C3812292", "name": "C3812292#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [27, 28]}}
{"token": ["The", "data", "suggest", "that", "the", "effects", "of", "long-term", "depolarization", "on", "ChAT", ",", "TOH", "and", "C0001044#ent", "<e1>", "are", "mediated", "by", "C1413043#ent", "<e2>", "+", "entry", "specifically", "through", "voltage-sensitive", "channels", "the", "L-type", "."], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [19, 20]}}
{"token": ["Nine", "patients", "with", "C0028754#ent", "<e1>", "evaluated", "for", "the", "presence", "of", "Helicobacter", "pylon", "C1415692#ent", "<e2>", ")", "before", "gastric", "reduction", "and", "all", "were", "negative", "."], "h": {"id": "C0028754", "name": "C0028754#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [12, 13]}}
{"token": ["These", "C0017837#ent", "<e1>", "pi", "expression", "vectors", "were", "cotransfected", "with", "pSV2neo", "into", "C4025289#ent", "<e2>", "MCF-7", "human", "breast", "cancer", "cells", "which", "have", "low", "amounts", "of", "C0017837#ent", "<e1>", "activity", "and", "which", "do", "not", "express", "C0017837#ent", "<e1>", "pi", "."], "h": {"id": "C4025289", "name": "C4025289#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [1, 2]}}
{"token": ["Clinical", "results", "C0915142#ent", "<e1>", "with", "ketorolac", ",", "a", "C0003211#ent", "<e2>", ",", "which", "is", "the", "only", "non-narcotic", "analgesic", "in", "parenteral", "formulation", "can", "be", "administered", "for", "the", "relief", "of", "moderate", "to", "severe", "acute", "pain"], "h": {"id": "C0915142", "name": "C0915142#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [8, 9]}}
{"token": ["It", "is", "currently", "unclear", "whether", "the", "risk", "of", "developing", "upper", "GI", "events", "with", "C0915142#ent", "<e1>", "plus", "aspirin", "is", "lower", "than", "it", "is", "with", "C0003211#ent", "<e2>", "plus", "aspirin", "."], "h": {"id": "C0915142", "name": "C0915142#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [23, 24]}}
{"token": ["The", "response", "to", "increased", "C1418873#ent", "<e1>", "was", "different", "in", "the", "C1706333#ent", "<e2>", "vs.", "LCX", ";", "increasing", "C1418873#ent", "<e1>", "decreased", "capacitance", "in", "the", "LCX", "but", "increased", "capacitance", "in", "the", "C1706333#ent", "<e2>", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418873", "name": "C1418873#ent", "pos": [4, 5]}}
{"token": ["The", "C1706327#ent", "<e1>", "closely", "linked", "to", "each", "other", "and", "to", "C1419009#ent", "<e2>", "."], "h": {"id": "C1706327", "name": "C1706327#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419009", "name": "C1419009#ent", "pos": [10, 11]}}
{"token": ["In", "addition", "to", "the", "interaction", "with", "C0065610#ent", "<e1>", ",", "apoB", "was", "also", "found", "to", "be", "associated", "with", "C1413107#ent", "<e2>", ",", "confirming", "previous", "studies", ",", "and", "with", "proteins", "bearing", "the", "KDEL", "retention", "signal", "."], "h": {"id": "C0065610", "name": "C0065610#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413107", "name": "C1413107#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "mouse", "mad-related", "genes", "Smad4/Dpc4", "and", "C1566790#ent", "<e1>", "(", "homolog", "of", "C1334468#ent", "<e2>", ",", "as", "candidates", "for", "involvement", "in", "lung", "tumor", "resistance", "suppression", "."], "h": {"id": "C1566790", "name": "C1566790#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334468", "name": "C1334468#ent", "pos": [16, 17]}}
{"token": ["C1566790#ent", "<e1>", "and", "Smad4/DPC4", ",", "other", "members", "of", "the", "C1334468#ent", "<e2>", "are", "possibly", "tumor", "suppressor", "genes", "alterations", "of", "these", "genes", "occurred", "in", "various", "carcinomas", "."], "h": {"id": "C1566790", "name": "C1566790#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334468", "name": "C1334468#ent", "pos": [9, 10]}}
{"token": ["C0030956#ent", "<e1>", "contain", "the", "basic", "region", "of", "the", "C1333930#ent", "<e2>", "bind", "specifically", "to", "a", "bulged", "region", "in", "TAR", "RNA", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333930", "name": "C1333930#ent", "pos": [8, 9]}}
{"token": ["However", ",", "an", "C0002085#ent", "<e1>", "imbalance", "of", "C0812244#ent", "<e2>", "was", "the", "most", "remarkable", "independent", "predictive", "factor", "poor", "patient", "survival", "P=0.0002", ",", "risk", "ratio", "3382", ")", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812244", "name": "C0812244#ent", "pos": [7, 8]}}
{"token": ["Females", "also", "have", "a", "higher", "incidence", "of", "C0860207#ent", "<e1>", "toxicity", ",", "gastrointestinal", "adverse", "events", "to", "NSAIDs", ",", "and", "C0585186#ent", "<e2>"], "h": {"id": "C0860207", "name": "C0860207#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0585186", "name": "C0585186#ent", "pos": [18, 19]}}
{"token": ["C1414546#ent", "<e1>", "is", "an", "activating", ",", "C0018854#ent", "<e2>", "associated", ",", "Fc", "receptor", "IgA", "expressed", "on", "myeloid", "cells"], "h": {"id": "C1414546", "name": "C1414546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018854", "name": "C0018854#ent", "pos": [6, 7]}}
{"token": ["In", "contrast", ",", "the", "C2984537#ent", "<e1>", "agonist", "bezafibrate", "had", "no", "impact", "on", "the", "RSV-induced", "C1706544#ent", "<e2>", "expression", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [14, 15]}}
{"token": ["The", "same", "C1425440#ent", "<e1>", "concentration", "applied", "to", "grown", "CEC", "C0872351#ent", "<e2>", "inhibited", "the", "growth", "of", "TBEV", "but", "not", "the", "growth", "of", "HHV", "1", "while", "interferon", "was", "slightly", "stimulated", "."], "h": {"id": "C1425440", "name": "C1425440#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [9, 10]}}
{"token": ["With", "moderate", "saline", "loading", "C0301544#ent", "<e1>", "and", "chlorthiazide", "were", "the", "most", "efficient", "C0596110#ent", "<e2>", "."], "h": {"id": "C0301544", "name": "C0301544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [12, 13]}}
{"token": ["No", "differences", "were", "found", "between", "C1541553#ent", "<e1>", "values", "obtained", "from", "patients", "with", "other", "malignancies", ",", "C0030305#ent", "<e2>", "or", "subjects", "without", "cancer", "."], "h": {"id": "C1541553", "name": "C1541553#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [15, 16]}}
{"token": ["The", "polyphenols", "analyzed", "belonged", "to", "two", "categories", ":", "benzoic", "acid", "derivatives", "including", "gallic", "acid", "protocatechuic", "acid", "vanillic", "acid", "and", "C0075709#ent", "<e1>", "and", "stilbenes", ",", "including", "astringin", ",", "C0071538#ent", "<e2>", ",", "and", "resveratrol", "(", "all", "trans", "isomers", "."], "h": {"id": "C0075709", "name": "C0075709#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0071538", "name": "C0071538#ent", "pos": [27, 28]}}
{"token": ["While", "oral", "contraceptives", "the", "midcycle", "increase", "of", "plasma", "C1337111#ent", "<e1>", ",", "the", "periovulatory", "plasma", "C1337111#ent", "<e1>", "peak", "was", "present", "during", "C0011816#ent", "<e1>", "treatment", "."], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "only", "C0162508#ent", "<e1>", ",", "junB", ",", "c-myc", ",", "and", "C1417932#ent", "<e2>", "expressed", "at", "a", "significantly", "elevated", "level", "in", "ER-1", "-", "2", "T", "cells", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [12, 13]}}
{"token": ["In", "turn", ",", "C0162508#ent", "<e1>", "may", "regulate", "genes", ",", "such", "as", "C1417932#ent", "<e2>", "which", "are", "responsible", "for", "cell", "proliferation", "differentiation", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [11, 12]}}
{"token": ["Dual", "combinations", "enviroxime", ",", "disoxaril", ",", "C0052370#ent", "<e1>", ",", "PTU-23", ",", "HBB", "and", "C0141224#ent", "<e2>", "were", "evaluated", "."], "h": {"id": "C0052370", "name": "C0052370#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0141224", "name": "C0141224#ent", "pos": [13, 14]}}
{"token": ["Chromosome", "studies", "carried", "out", "on", "the", "peripheral", "blood", "26", "epilepsy", "patients", "treated", "with", "phenobarbital", "and/or", "C0237417#ent", "<e1>", ",", "on", "ten", "healthy", "controls", "on", "eight", "untreated", "C0014544#ent", "<e2>"], "h": {"id": "C0237417", "name": "C0237417#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [25, 26]}}
{"token": ["Phenytoin", "(", "C0237417#ent", "<e1>", ",", "DPH", ")", ",", "an", "anticonvulsant", "drug", "C0014544#ent", "<e2>", "patients", ",", "has", "several", "adverse", "effects", "including", "calvarial", "thickening", "coarsening", "of", "the", "facial", "features", ",", "which", "occur", "with", "chronic", "DPH", "therapy", "."], "h": {"id": "C0237417", "name": "C0237417#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [11, 12]}}
{"token": ["Immunohistochemical", "and", "immunoblot", "analysis", "abnormal", "expression", "of", "C1413902#ent", "<e1>", "and", "laminin-alpha2", "supporting", "the", "hypothesis", "that", "C1425226#ent", "<e2>", "has", "a", "role", "in", "the", "interaction", "between", "the", "extracellular", "matrix", "components", "."], "h": {"id": "C1413902", "name": "C1413902#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1425226", "name": "C1425226#ent", "pos": [15, 16]}}
{"token": ["Our", "results", "demonstrate", "that", "basal", "and", "meal-stimulated", "C1413167#ent", "<e1>", "levels", "in", "patients", "with", "C0267963#ent", "<e2>", "not", "differ", "from", "controls", "."], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0267963", "name": "C0267963#ent", "pos": [13, 14]}}
{"token": ["It", "has", "been", "claimed", "that", "C1413167#ent", "<e1>", "CCK", ")", "concentrations", "are", "raised", "in", "patients", "with", "C0267963#ent", "<e2>"], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0267963", "name": "C0267963#ent", "pos": [15, 16]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "evaluate", "the", "safety", "and", "efficacy", "of", "botulinum", "toxin", "type", "A", "BoNT-A", ";", "C0700702#ent", "<e1>", ",", "Allergan", ",", "Inc.", ")", "for", "the", "prophylactic", "treatment", "C0752147#ent", "<e2>", "CDH", ")", "."], "h": {"id": "C0700702", "name": "C0700702#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0752147", "name": "C0752147#ent", "pos": [30, 31]}}
{"token": ["Severe", "C0007682#ent", "<e1>", "such", "as", "C0014060#ent", "<e2>", ",", "have", "been", "reported", "in", "association", "with", "Mycoplasma", "pneumoniae", "infections"], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [5, 6]}}
{"token": ["A", "supportive", "role", "for", "IL-4", "in", "the", "C0007682#ent", "<e1>", "suggested", "by", "the", "presence", "of", "IL-4", "RNA", "the", "C0014060#ent", "<e2>", "brains", "of", "rhesus", "macaques", "reduced", "levels", "of", "this", "cytokine", "in", "the", "brains", "from", "pig-tailed", "macaques"], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [17, 18]}}
{"token": ["The", "contribution", "of", "sodium", "glucose-linked", "transporter", "1", "C1420120#ent", "<e1>", ")", "to", "total", "glucose", "uptake", "estimated", "by", "inhibiting", "C1420120#ent", "<e1>", "with", "C0885670#ent", "<e1>", "(", "100", "micromol/L", ")", "."], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0885670", "name": "C0885670#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "calcitonin", "is", "able", "to", "potentiate", "a", "non-PTX-sensitive", "mechanism", "of", "transduction", "and", "support", "the", "possibility", "of", "involvement", "of", "similar", "C0752065#ent", "<e1>", "in", "the", "effects", "of", "opioid", "and", "C0001640#ent", "<e2>"], "h": {"id": "C0752065", "name": "C0752065#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [30, 31]}}
{"token": ["A", "variety", "of", "C0752065#ent", "<e1>", "are", "involved", "in", "the", "coupling", "of", "the", "various", "C0001640#ent", "<e2>", "subtypes", "to", "intracellular", "second", "messenger", "systems", ",", "which", "ultimately", "produce", "the", "end-organ", "response", "."], "h": {"id": "C0752065", "name": "C0752065#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [13, 14]}}
{"token": ["This", "study", "reports", "the", "effects", "of", "C0035629#ent", "<e1>", "on", "the", "gene", "expression", "C4283880#ent", "<e2>", "in", "PC12", "cells"], "h": {"id": "C0035629", "name": "C0035629#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4283880", "name": "C4283880#ent", "pos": [12, 13]}}
{"token": ["Several", "studies", "have", "reported", "an", "association", "between", "hyperhomocysteinemia", ",", "C0048860#ent", "<e1>", "MTHFR", ")", "polymorphisms", "and", "cleft", "lip", "or", "without", "cleft", "palate", "C1413769#ent", "<e2>", ")", ",", "and", "congenital", "heart", "defects", "CHDs", ")", "."], "h": {"id": "C0048860", "name": "C0048860#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413769", "name": "C1413769#ent", "pos": [21, 22]}}
{"token": ["Recently", ",", "we", "identified", "the", "C0079429#ent", "<e1>", ",", "CHAC", ",", "encoding", "a", "novel", "protein", ",", "C1413372#ent", "<e2>", ",", "in", "which", "a", "deletion", "mutation", "was", "found", "in", "Japanese", "families", "with", "CHAC", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413372", "name": "C1413372#ent", "pos": [15, 16]}}
{"token": ["Addition", "of", "C0012789#ent", "<e1>", ",", "but", "not", "NAC", "or", "C1417239#ent", "<e2>", ",", "after", "APAP", "exposure", "protected", "the", "hepatocytes", "from", "plasma", "membrane", "damage", "the", "post-exposure", "period", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417239", "name": "C1417239#ent", "pos": [9, 10]}}
{"token": ["Later", "on", ",", "another", "disorder", "similar", "to", "but", "different", "from", "C0027126#ent", "<e1>", "described", "as", "C0553604#ent", "<e2>", "PROMM", ")", "."], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0553604", "name": "C0553604#ent", "pos": [14, 15]}}
{"token": ["To", "compare", "brain", "involvement", "in", "C0027126#ent", "<e1>", "DM", ")", "with", "that", "of", "C0553604#ent", "<e2>", "PROMM", ")", "."], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0553604", "name": "C0553604#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "(", "6", "C2677590#ent", "<e1>", ")", "on", "the", "transport", "of", "C3536863#ent", "<e2>", "and", "water", "in", "the", "cauda", "epididymidis", "fertility", "of", "male", "rats", "were", "studied", "."], "h": {"id": "C2677590", "name": "C2677590#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [12, 13]}}
{"token": ["The", "T9176", "G", "mutation", "changes", "a", "highly", "conserved", "leucine", "residue", "to", "an", "arginine", "in", "subunit", "6", "of", "C1706373#ent", "<e1>", "and", "is", "maternally", "inherited", "like", "mutations", "in", "the", "other", "C1563761#ent", "<e2>"], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1563761", "name": "C1563761#ent", "pos": [28, 29]}}
{"token": ["Two", "of", "these", "receptors", "(", "NTR1", "and", "C1420808#ent", "<e1>", ")", "belong", "to", "the", "C0872043#ent", "<e2>", "whereas", "the", "third", "one", "(", "NTR3", ")", "is", "a", "type", "I", "receptor", "a", "single", "transmembrane", "domain"], "h": {"id": "C1420808", "name": "C1420808#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0872043", "name": "C0872043#ent", "pos": [13, 14]}}
{"token": ["This", "pattern", "of", "expression", "is", "in", "contrast", "to", "that", "observed", "for", "other", "C1335554#ent", "<e1>", "expressed", "in", "T", "lymphocytes", "CD45", ",", "C1705231#ent", "<e2>", ",", "SHP", ",", "and", "PEP", "."], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705231", "name": "C1705231#ent", "pos": [20, 21]}}
{"token": ["We", "report", "in", "the", "present", "study", "that", "the", "active", "form", "C0084340#ent", "<e1>", "increases", "the", "expression", "of", "utrophin", ",", "the", "autosomal", "homologue", "C1414083#ent", "<e2>", "in", "the", "mouse", "C2C12", "and", "rat", "L8", "myoblastic", "cell", "lines", "."], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [21, 22]}}
{"token": ["We", "performed", "recording", "of", "the", "magnetic", "fields", "Magnetomyography", "-", "MMG", ")", "corresponding", "to", "the", "electrical", "activity", "the", "C0567085#ent", "<e1>", "smooth", "muscle", "a", "device", "called", "C1419815#ent", "<e2>", ",", "(", "SQuid", "Array", "Reproductive", "Assessment", ")", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419815", "name": "C1419815#ent", "pos": [24, 25]}}
{"token": ["Pretreatment", "with", "C0099122#ent", "<e1>", "(", "50", "pmol", ")", ",", "a", "selective", "C0001641#ent", "<e2>", "of", "non-NMDA", "receptors", "suppressed", "the", "swallows", "elicited", "by", "glutamate", "and", "strongly", "inhibited", "the", "response", "elicited", "by", "quisqualate", "microinjections", "."], "h": {"id": "C0099122", "name": "C0099122#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [11, 12]}}
{"token": ["NMDA", "was", "isolated", "pharmacologically", "by", "applying", "a", "solution", "containing", "the", "non-NMDA", "receptor", "antagonist", ",", "6-cyano-7-nitroquinoxaline-2,3-dione", "(", "C0099122#ent", "<e1>", ")", "and", "the", "gamma-aminobutyric", "acidA", "GABAA", ")", "C0001641#ent", "<e2>", "picrotoxin", "and", "increasing", "the", "stimulus", "intensity"], "h": {"id": "C0099122", "name": "C0099122#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [25, 26]}}
{"token": ["Also", ",", "the", "epileptiform", "activity", "was", "suppressed", "by", "the", "AMPAR", "antagonist", "C0099122#ent", "<e1>", ",", "or", "the", "C0001641#ent", "<e2>", "of", "AMPAR", "desensitization", ",", "cyclothiazide", "."], "h": {"id": "C0099122", "name": "C0099122#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [16, 17]}}
{"token": ["Pneumonia", ",", "in", "infants", "suffering", "from", "esophageal", "atresia", "lower", "esophageal", "fistula", "is", "usually", "caused", "by", "gastric", "reflux", "the", "fistula", ",", "In", "order", "to", "abolish", "the", "C0018834#ent", "<e1>", "of", "the", "gastric", "content", ",", "C0008783#ent", "<e2>", "i.v", "."], "h": {"id": "C0018834", "name": "C0018834#ent", "pos": [25, 26]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [32, 33]}}
{"token": ["They", "suggest", "determination", "of", "the", "preoperative", "basal", "gastric", "C0018834#ent", "<e1>", "level", "and", "a", "C0008783#ent", "<e2>", "suppression", "test", "identify", "patients", "at", "high", "risk", "recurrence", "of", "the", "ulcer", "."], "h": {"id": "C0018834", "name": "C0018834#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [13, 14]}}
{"token": ["MMP-8", "(", "C0162745#ent", "<e1>", ")", "is", "the", "most", "effective", "C0162745#ent", "<e1>", "to", "initiate", "type", "I", "collagen", "degradation", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [2, 3]}}
{"token": ["C0333997#ent", "<e1>", "seen", "in", "patients", "with", "C0272236#ent", "<e2>", "normal", "AID", "as", "well", "as", "the", "patients", "with", "C0272236#ent", "<e2>", "defects", "in", "AID", "."], "h": {"id": "C0333997", "name": "C0333997#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0272236", "name": "C0272236#ent", "pos": [6, 7]}}
{"token": ["C0003462#ent", "<e1>", "caused", "by", "Clostridium", "tetani", "is", "one", "of", "the", "most", "common", "C0005943#ent", "<e2>", "."], "h": {"id": "C0003462", "name": "C0003462#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [12, 13]}}
{"token": ["The", "decreased", "formation", "of", "TXB2", "was", "not", "only", "secondary", "to", "reduced", "release", "of", "histamine", ",", "since", "C2697656#ent", "<e1>", "inhibited", "TXB2", "formation", "in", "the", "presence", "of", "C0034282#ent", "<e2>", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034282", "name": "C0034282#ent", "pos": [25, 26]}}
{"token": ["A", "resistant", "clone", "harboring", "a", "recombinant", "plasmid", "a", "3.1-kb", "insert", "that", "contained", "the", "C0917574#ent", "<e1>", "gadA", ")", "and", "C0001900#ent", "<e2>", "alrA", ")", "genes", "was", "identified", "."], "h": {"id": "C0917574", "name": "C0917574#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001900", "name": "C0001900#ent", "pos": [18, 19]}}
{"token": ["C0085431#ent", "<e1>", "RNases", "H", "comprise", "a", "family", "of", "metal-dependent", "C3540790#ent", "<e2>", "that", "catalyze", "the", "hydrolysis", "of", "the", "3'-O", "---", "P", "bond", "of", "RNA", "in", "RNA.DNA", "hybrids", "."], "h": {"id": "C0085431", "name": "C0085431#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "the", "presence", "and", "role", "of", "a", "recently", "C0769345#ent", "<e1>", "cathepsin", "S", "in", "the", "digestion", "of", "rod", "outer", "segments", "C0289313#ent", "<e2>", ")", "by", "cultured", "retinal", "pigment", "epithelial", "RPE", ")", "cells", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [20, 21]}}
{"token": ["We", "conclude", "that", "this", "method", "is", "useful", "in", "differentiating", "interstitial", "disorders", "C0041912#ent", "<e1>", ",", "and", "also", "CB", "from", "C0054757#ent", "<e2>", ",", "because", "it", "can", "detect", "lung", "stiffness", "and", "can", "identify", "sites", "of", "airway", "narrowing"], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0054757", "name": "C0054757#ent", "pos": [18, 19]}}
{"token": ["The", "mean", "best", "corrected", "visual", "acuity", "that", "reached", "0.23", ",", "is", "limited", "especially", "by", "C0002418#ent", "<e1>", "and", "other", "C0015397#ent", "<e2>"], "h": {"id": "C0002418", "name": "C0002418#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [18, 19]}}
{"token": ["The", "C1417679#ent", "<e1>", "sequenced", "were", "isocitrate", "dehydrogenase", "malic", "enzyme", "C1417244#ent", "<e2>", "glucose-6-phosphate", "dehydrogenase", "and", "fumarate", "hydratase", "for", "17", "strains", "of", "L.", "infantum", ",", "seven", "strains", "of", "L.", "donovani", ",", "and", "three", "strains", "of", "L.", "archibaldi", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417244", "name": "C1417244#ent", "pos": [9, 10]}}
{"token": ["C1419986#ent", "<e1>", "induced", "a", "reduction", "in", "C1382029#ent", "<e2>", "activity", "during", "this", "same", "interval", "of", "."], "h": {"id": "C1419986", "name": "C1419986#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [6, 7]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "assess", "the", "diaphragmatic", "excursion", "the", "TM-mode", "ultrasonography", "concomitant", "pneumotachography", "in", "eight", "normal", "and", "five", "C0004096#ent", "<e1>", "subjects", "before", "and", "after", "C0543495#ent", "<e2>", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}, "relation": "may_be_treated_by", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [27, 28]}}
{"token": ["C3539618#ent", "<e1>", "failed", "to", "affect", "the", "C2926735#ent", "<e2>", "of", "slow-wave", "sleep", "PS", "and", "total", "sleep", "time"], "h": {"id": "C3539618", "name": "C3539618#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [6, 7]}}
{"token": ["Thirteen", "children", "(", "45", "%", ")", "completed", "the", "elimination", "diet", "seven", "of", "these", "were", "improved", "on", "parental", "assessment", "of", "C0917801#ent", "<e1>", ",", "itchiness", "and", "area", "of", "C0013595#ent", "<e2>", "."], "h": {"id": "C0917801", "name": "C0917801#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [26, 27]}}
{"token": ["Antibody", "against", "the", "extracellular", "region", "detected", "a", "protein", "of", "220", "to", "250", "C1839259#ent", "<e1>", "in", "human", "hematopoietic", "cell", "lines", "expressing", "C3813176#ent", "<e2>", "mRNA", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3813176", "name": "C3813176#ent", "pos": [20, 21]}}
{"token": ["These", "results", "indicate", "that", "the", "Jsr", "mutation", "disrupts", "the", "A-P", "polarity", "of", "somites", "during", "the", "somitogenesis", "without", "altering", "C1416828#ent", "<e1>", "expression", "pattern", "in", "the", "C1310550#ent", "<e2>", "."], "h": {"id": "C1416828", "name": "C1416828#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1310550", "name": "C1310550#ent", "pos": [24, 25]}}
{"token": ["Recent", "studies", "show", "that", "the", "cyclic", "expression", "C1416828#ent", "<e1>", "in", "the", "presomitic", "mesoderm", "C1310550#ent", "<e2>", ")", "is", "controlled", "at", "the", "transcription", "level", "by", "Notch", "signal", "the", "CBF1", "binding", "site", "activation", "and", "periodic", "repression", "the", "C1416828#ent", "<e1>", "promoter", "."], "h": {"id": "C1416828", "name": "C1416828#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1310550", "name": "C1310550#ent", "pos": [13, 14]}}
{"token": ["To", "study", "lipid", "peroxidation", "LPO", ")", "and", "anti-oxidant", "system", "(", "C0265268#ent", "<e1>", ")", "in", "patients", "with", "C0019693#ent", "<e2>"], "h": {"id": "C0265268", "name": "C0265268#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [16, 17]}}
{"token": ["All", "four", "inhibitors", "with", "C-terminal", "aldehyde", ",", "leupeptin", ",", "chymostatin", ",", "Boc-Gln-Leu-Lys-H", "and", "C0174817#ent", "<e1>", "completely", "blocked", "C4283796#ent", "<e2>", "activity", "."], "h": {"id": "C0174817", "name": "C0174817#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [17, 18]}}
{"token": ["Antibodies", "exhibited", "a", "variable", "cross-reactivity", "for", "metabolites", "and", "structural", "analogs", "of", "C0009262#ent", "<e1>", ",", "which", "were", "dependent", "on", "the", "site", "at", "which", "C0009262#ent", "<e1>", "coupled", "to", "the", "C1968832#ent", "<e1>"], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1968832", "name": "C1968832#ent", "pos": [27, 28]}}
{"token": ["Antithrombin", "III", "C0724532#ent", "<e1>", ")", "is", "a", "physiological", "inhibitor", "of", "thrombin", "and", "other", "C0036734#ent", "<e2>", "and", "has", "antiinflammatory", "properties"], "h": {"id": "C0724532", "name": "C0724532#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [13, 14]}}
{"token": ["Molar", "proportions", "of", "acetate", "were", "greater", "(", "P", "less", "than", ".05", ")", "at", "3", "h", "after", "sunrise", "in", "C0023381#ent", "<e1>", "and", "LSD", "than", "in", "EGS", "and", "C0238111#ent", "<e2>", "."], "h": {"id": "C0023381", "name": "C0023381#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [26, 27]}}
{"token": ["Ruminal", "ammonia", "concentrations", "were", "lower", "(", "P", "less", "than", ".05", ")", "in", "C0023381#ent", "<e1>", "and", "LSD", "than", "in", "EGS", "and", "C0238111#ent", "<e2>", "at", "3", "and", "6", "h", "after", "sunrise", "."], "h": {"id": "C0023381", "name": "C0023381#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [20, 21]}}
{"token": ["We", "here", "in", "report", "a", "24-year", "old", "female", "patient", "who", "was", "found", "to", "have", "C0039730#ent", "<e1>", "minor", "and", "nephrocalcinosis", "with", "evidence", "of", "C0015624#ent", "<e2>"], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [22, 23]}}
{"token": ["Western", "blot", "analysis", "the", "liver", "tissues", "that", "LPS/d-GalN", "treatment", "for", "4", "h", "induced", "much", "higher", "cleavage", "of", "C0032405#ent", "<e1>", "caspase-3", ",", "and", "caspase-9", "in", "C1705323#ent", "<e2>", "transgenic", "mice", "in", "wild-type", "mice", "."], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [24, 25]}}
{"token": ["The", "activity", "of", "other", "enzymes", "was", "either", "lower", "(", "glutamate", "dehydrogenase", ",", "moderately", "higher", "C0031653#ent", "<e1>", ",", "lactate", "dehydrogenase", "or", "considerably", "greater", "(", "C0029282#ent", "<e2>", "in", "tumoral", "than", "in", "normal", "islet", "cells"], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [23, 24]}}
{"token": ["Not", "only", "the", "exogenously", "expressed", "but", "also", "IFN-gamma-induced", "C1824738#ent", "<e1>", "was", "inhibited", "by", "C3813181#ent", "<e2>", "."], "h": {"id": "C1824738", "name": "C1824738#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3813181", "name": "C3813181#ent", "pos": [13, 14]}}
{"token": ["This", "inhibition", "did", "not", "result", "from", "an", "association", "between", "C3813181#ent", "<e1>", "and", "C1824738#ent", "<e2>", "but", "depended", "on", "the", "intact", "Cyclin", "T1-binding", "domain", "in", "C3813181#ent", "<e1>", "."], "h": {"id": "C1824738", "name": "C1824738#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3813181", "name": "C3813181#ent", "pos": [9, 10]}}
{"token": ["These", "results", "indicated", "that", "augmented", "C3489929#ent", "<e1>", "the", "skeletal", "muscle", "attenuate", "insulin", "resistance", "in", "patients", "with", "type", "2", "diabetes", "C0524620#ent", "<e2>"], "h": {"id": "C3489929", "name": "C3489929#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [19, 20]}}
{"token": ["A", "massive", "cerebral", "release", "of", "C3539946#ent", "<e1>", "ammonia", "was", "found", "in", "early-onset", "dementia", "of", "C0002395#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [14, 15]}}
{"token": ["Laboratory", "examination", "C0015625#ent", "<e1>", "with", "appearance", "of", "blasts", ",", "C0020455#ent", "<e2>", "and", "elevated", "titers", "of", "ANA", ",", "anti", "SS-A", "anti", "SS-B.", "Bone", "marrow", "aspirate", "increased", "myeloblasts", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020455", "name": "C0020455#ent", "pos": [9, 10]}}
{"token": ["The", "alcohol", "n-butanol", "a", "phospholipase", "D", "C1415545#ent", "<e1>", "besides", "inhibiting", "constitutive", "C1335224#ent", "<e2>", "secretion", ",", "blocked", "staurosporine-induced", "secretion", "."], "h": {"id": "C1415545", "name": "C1415545#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335224", "name": "C1335224#ent", "pos": [11, 12]}}
{"token": ["The", "reduction", "in", "the", "incorporation", "of", "leucine", "into", "parasite", "proteins", "nonspecific", "and", "preceded", "the", "effect", "of", "the", "C1254351#ent", "<e1>", "on", "the", "uptake", "of", "the", "C2917660#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [24, 25]}}
{"token": ["In", "the", "astrocytic", "membrane-associated", "fraction", ",", "C1417869#ent", "<e1>", "an", "additional", "minor", "endoproteolytic", "cleavage", "the", "Pro3-Tyr4", "bond", "elicited", "by", "C0025250#ent", "<e2>", "as", "suggested", "by", "the", "protective", "effect", "its", "blocking", "agent", "phosphoramidon", "."], "h": {"id": "C1417869", "name": "C1417869#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [18, 19]}}
{"token": ["Sulphasalazine", "and", "C0036078#ent", "<e1>", "do", "not", "inhibit", "C0038838#ent", "<e2>", "production", "after", "stimulation", "with", "the", "ester", "phorbol", "myristate", "acetate", "a", "stimulus", "response", "which", "is", "independent", "of", "intracellular", "Ca++", "increase", "."], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [7, 8]}}
{"token": ["C0036078#ent", "<e1>", "and", "sulphapyridine", "do", "not", "inhibit", "C0038838#ent", "<e2>", "production", "after", "stimulation", "with", "the", "ester", "phorbol", "myristate", "acetate", "a", "stimulus", "response", "which", "is", "independent", "of", "intracellular", "Ca++", "increase", "."], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [7, 8]}}
{"token": ["A", "patient", "is", "reported", "with", "C1704417#ent", "<e1>", "and", "clinical", "features", "resembling", "the", "C0000744#ent", "<e2>", "abetalipoproteinaemia", ")", "more", "completely", "than", "previously", "described", "."], "h": {"id": "C1704417", "name": "C1704417#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [12, 13]}}
{"token": ["Hence", ",", "both", "striate", "and", "extrastriate", "visual", "cortex", "affected", "by", "the", "pathology", "of", "C0376329#ent", "<e1>", ",", "the", "pathological", "changes", "being", "most", "severe", "in", "C1417639#ent", "<e2>", "."], "h": {"id": "C0376329", "name": "C0376329#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417639", "name": "C1417639#ent", "pos": [23, 24]}}
{"token": ["Its", "five", "tandem", "zinc", "finger", "motifs", "exhibit", "highest", "homology", "with", "those", "of", "members", "of", "the", "C0812304#ent", "<e1>", "and", "Zic", "subfamilies", "of", "C4288353#ent", "<e2>"], "h": {"id": "C0812304", "name": "C0812304#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4288353", "name": "C4288353#ent", "pos": [21, 22]}}
{"token": ["The", "sequence", "of", "the", "zinc", "finger", "domain", "highest", "homology", "with", "those", "of", "members", "of", "the", "C0812304#ent", "<e1>", "and", "ZIC", "subfamilies", "of", "C4288353#ent", "<e2>"], "h": {"id": "C0812304", "name": "C0812304#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4288353", "name": "C4288353#ent", "pos": [21, 22]}}
{"token": ["Its", "five", "tandem", "Cys(2)-His(2", ")", "zinc", "finger", "motifs", "exhibit", "the", "highest", "homology", "to", "those", "of", "members", "of", "the", "C0812304#ent", "<e1>", "and", "Zic", "subfamilies", "of", "C4288353#ent", "<e2>"], "h": {"id": "C0812304", "name": "C0812304#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4288353", "name": "C4288353#ent", "pos": [24, 25]}}
{"token": ["All", "C0162534#ent", "<e1>", "SEs", ")", "are", "slow", "virus-transmissible", "C0009450#ent", "<e2>", "the", "brain", "."], "h": {"id": "C0162534", "name": "C0162534#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [8, 9]}}
{"token": ["It", "is", "often", "highly", "C0162534#ent", "<e1>", "and", "carriage", "seems", "to", "lead", "to", "C0009450#ent", "<e2>", "more", "frequently", "than", "with", "MSSA", "carriage", "."], "h": {"id": "C0162534", "name": "C0162534#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [12, 13]}}
{"token": ["The", "histological", "diagnoses", "the", "operative", "specimen", "C0013504#ent", "<e1>", "in", "43", "patients", ",", "C0333980#ent", "<e2>", "FNH", ")", "in", "12", "patients", ",", "liver", "cell", "adenoma", "8", "patients", ",", "cavernous", "hemangioma", "8", "patients", ",", "and", "congenital", "cyst", "4", "patients", "."], "h": {"id": "C0013504", "name": "C0013504#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0333980", "name": "C0333980#ent", "pos": [12, 13]}}
{"token": ["APACHE", "II", "prior", "to", "treatment", "were", "significantly", "higher", "in", "C3539565#ent", "<e1>", "patients", "(", "20.9", "C3539565#ent", "<e1>", "versus", "12.4", "C3811118#ent", "<e1>", ",", "p", "<", "0.01", ")", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [18, 19]}}
{"token": ["CC", "and", "C3539565#ent", "<e1>", "were", "predominantly", "CK7-/CK20-", ";", "C3811118#ent", "<e2>", ",", "CK7+/20-", ";", "CPC", ",", "CK7+/CK20-", "or", "CK7-/CK20-", ";", "and", "UC", ",", "CK7+/CK20-", "or", "CK7+/CK20", "+", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [8, 9]}}
{"token": ["Slow", "degradation", "aerobic", "conditions", "prevented", "by", "the", "presence", "of", "glutathione", ",", "whereas", "C0033628#ent", "<e1>", "well", "as", "one-electron", "oxidants", "or", "reductants", "promoted", "monomerization", "of", "C1423949#ent", "<e2>", "."], "h": {"id": "C0033628", "name": "C0033628#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423949", "name": "C1423949#ent", "pos": [23, 24]}}
{"token": ["The", "effect", "of", "C0006945#ent", "<e1>", ",", "a", "muscarinic", "acetylcholine", "agonist", "on", "the", "secretion", "of", "gastric", "C1418617#ent", "<e2>", "and", "on", "its", "mRNA", "level", "in", "the", "gastric", "mucosa", "examined", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418617", "name": "C1418617#ent", "pos": [15, 16]}}
{"token": ["Collectively", ",", "these", "results", "show", "that", "MAPK", "activity", "is", "inhibited", "by", "progestin", "and", "C1415223#ent", "<e1>", "and", "suggest", "that", "C1825027#ent", "<e2>", "ERK", "inactivation", "is", "mediated", "through", "C1415223#ent", "<e1>", "."], "h": {"id": "C1415223", "name": "C1415223#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1825027", "name": "C1825027#ent", "pos": [18, 19]}}
{"token": ["PGE(2)", "induction", "of", "C3887694#ent", "<e1>", "gene", "expression", "inhibited", "by", "the", "adenylate", "cyclase", "inhibitor", "2',5'-dideoxyadenosine", ",", "by", "the", "C0033640#ent", "<e2>", "PKA", ")", "inhibitor", "H-89", ",", "and", "by", "a", "dominant-negative", "PKA", "construct", "."], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [17, 18]}}
{"token": ["Serum", "binding", "C0036077#ent", "<e1>", ",", "frusemide", ",", "fenclofenac", "and", "C0031412#ent", "<e2>", "and", "a", "range", "of", "steroid", "hormones", "similar", "in", "FDH", "and", "normal", "sera"], "h": {"id": "C0036077", "name": "C0036077#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [9, 10]}}
{"token": ["C0002986#ent", "<e1>", "a", "rare", ",", "X-chromosome", "linked", "C0017361#ent", "<e2>", "lysosomal", "storage", "disorder"], "h": {"id": "C0002986", "name": "C0002986#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [7, 8]}}
{"token": ["C0002986#ent", "<e1>", "a", "rare", "X-linked", ",", "C0017361#ent", "<e2>", ",", "glycolipid", "storage", "disorder"], "h": {"id": "C0002986", "name": "C0002986#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [6, 7]}}
{"token": ["TIAF1", "inhibits", "the", "cytotoxic", "effects", "TNF-alpha", "and", "C3889446#ent", "<e1>", "TNF", "receptor", "adaptors", "TRADD", "FADD", ",", "and", "C1826849#ent", "<e2>", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826849", "name": "C1826849#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "a", "recent", "study", "found", "C2699000#ent", "<e1>", ",", "a", "direct", "thromboxane", "inhibitor", "to", "be", "superior", "to", "C0004057#ent", "<e2>", "in", "diabetic", "patients", "."], "h": {"id": "C2699000", "name": "C2699000#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [18, 19]}}
{"token": ["The", "effects", "of", "C2699000#ent", "<e1>", "were", "compared", "to", "those", "of", "C0004057#ent", "<e2>", "ASA", ")", "."], "h": {"id": "C2699000", "name": "C2699000#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "indicate", "the", "therapeutic", "value", "ephedrine", "sulfate", "propranolol", "in", "stress", "urinary", "incontinence", "phenoxybenzamine", "in", "C1997362#ent", "<e1>", "functional", "outlet", "obstruction", "phenoxybenzamine", "plus", "bethanechol", "in", "C0005697#ent", "<e2>", "and", "imipramine", "in", "enuresis", "."], "h": {"id": "C1997362", "name": "C1997362#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [24, 25]}}
{"token": ["Despite", "treatment", "with", "succimer", "C0012384#ent", "<e1>", "her", "neuropathy", "progressed", "to", "ventilator", "dependence", "C0034372#ent", "<e2>", "."], "h": {"id": "C0012384", "name": "C0012384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034372", "name": "C0034372#ent", "pos": [12, 13]}}
{"token": ["The", "induction", "of", "JE", "and", "C0812445#ent", "<e1>", "were", "dependent", "upon", "the", "dose", "of", "C0175697#ent", "<e2>", "and", "exhibited", "different", "time", "courses"], "h": {"id": "C0812445", "name": "C0812445#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [13, 14]}}
{"token": ["Inspection", "of", "databanks", "showed", "similarities", "with", "pathogenesis-related", "proteins", "C4085573#ent", "<e1>", ")", "from", "plants", ",", "C1423060#ent", "<e2>", "mammals", "and", "venom", "allergen", "proteins", "from", "insects", "."], "h": {"id": "C4085573", "name": "C4085573#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1423060", "name": "C1423060#ent", "pos": [14, 15]}}
{"token": ["C1426204#ent", "<e1>", "CD", ")", "has", "been", "epidemiologically", "associated", "with", "C0524910#ent", "<e2>", "HCV", ")", ",", "and", "CD", "activation", "after", "the", "initiation", "of", "interferon", "(", "IFN-alpha", ")", "in", "patients", "with", "HCV", "is", "documented", "."], "h": {"id": "C1426204", "name": "C1426204#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524910", "name": "C0524910#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "C1420476#ent", "<e1>", "plays", "an", "essential", "role", "in", "cells", "lacking", "C1705860#ent", "<e2>", ",", "a", "kinase", "with", "significant", "homology", "to", "C1420476#ent", "<e1>", "."], "h": {"id": "C1705860", "name": "C1705860#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420476", "name": "C1420476#ent", "pos": [3, 4]}}
{"token": ["Also", ",", "C0030883#ent", "<e1>", "attenuated", ",", "but", "did", "not", "abolish", ",", "behaviorally", "determined", "C0235031#ent", "<e2>"], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235031", "name": "C0235031#ent", "pos": [13, 14]}}
{"token": ["Lipid", "peroxidation", "oxygenase", "and", "C0027021#ent", "<e1>", "activities", ",", "and", "the", "C0051169#ent", "<e2>", "concentration", "increased", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [10, 11]}}
{"token": ["However", ",", "in", "HL60", "cells", ",", "procarbazine", "was", "metabolized", "by", "C0027021#ent", "<e1>", "while", "iproniazid", "was", "metabolized", "mostly", "by", "the", "C0051169#ent", "<e2>"], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [19, 20]}}
{"token": ["C1705782#ent", "<e1>", "interacts", "with", "C1414201#ent", "<e2>", "Dvl2", ")", "and", "Diversin", "(", "Div", ")", ",", "which", "control", "cell", "morphology", "and", "other", "dynamic", "cell", "behaviors", "via", "the", "noncanonical", "Wnt", "and", "JNK", "pathways", "."], "h": {"id": "C1705782", "name": "C1705782#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414201", "name": "C1414201#ent", "pos": [4, 5]}}
{"token": ["C1705782#ent", "<e1>", "interacts", "with", "Dishevelled", "2", "C1414201#ent", "<e2>", ")", "and", "Diversin", "(", "Div", ")", ",", "which", "control", "cell", "morphology", "and", "other", "dynamic", "cell", "behaviors", "via", "the", "noncanonical", "Wnt", "and", "JNK", "pathways", "."], "h": {"id": "C1705782", "name": "C1705782#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414201", "name": "C1414201#ent", "pos": [6, 7]}}
{"token": ["All", "of", "these", "expressed", "one", "of", "two", "Arabidopsis", "cDNA", ",", "either", "AtTPPA", "or", "AtTPPB", ",", "which", "are", "both", "C1512488#ent", "<e1>", "to", "the", "C-terminal", "part", "the", "C4086885#ent", "<e2>", "other", "microbial", "trehalose-6-phosphate", "phosphatases"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4086885", "name": "C4086885#ent", "pos": [25, 26]}}
{"token": ["High", "Mg2", "+", "and", "the", "ROS", "scavenger", "C0001047#ent", "<e1>", "eliminated", "both", "the", "facilitatory", "and", "C0007681#ent", "<e2>", "effects", "of", "H2O2", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [14, 15]}}
{"token": ["Eighty-six", "patients", "with", "MSA", "comprised", "of", "14", "with", "striatonigral", "degeneration", "SND", ")", ",", "42", "with", "olivopontocerebellar", "atrophy", "C3811222#ent", "<e1>", ")", "and", "30", "with", "C0037019#ent", "<e2>", "SDS", ")", "."], "h": {"id": "C3811222", "name": "C3811222#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [23, 24]}}
{"token": ["Clinically", ",", "they", "consisted", "of", "9", "sporadic", "C3811222#ent", "<e1>", "including", "2", "cases", "with", "prominent", "C0037019#ent", "<e2>", "and", "4", "hereditary", "spinocerebellar", "degeneration"], "h": {"id": "C3811222", "name": "C3811222#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [14, 15]}}
{"token": ["This", "report", "indicates", "that", "C0020599#ent", "<e1>", "does", "not", "always", "distinguish", "C0268450#ent", "<e2>", "and", "Bartter", "syndromes"], "h": {"id": "C0020599", "name": "C0020599#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0268450", "name": "C0268450#ent", "pos": [10, 11]}}
{"token": ["One", "sibling", "has", "C0020599#ent", "<e1>", "and", "hypomagnesemia", ",", "consistent", "with", "C0268450#ent", "<e2>"], "h": {"id": "C0020599", "name": "C0020599#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0268450", "name": "C0268450#ent", "pos": [10, 11]}}
{"token": ["Less", "calcemic", "analogs", "of", "C3543418#ent", "<e1>", ",", "in", "combination", "with", "bone", "sparing", "products", "as", "C3541401#ent", "<e2>", "allow", "immune", "modulation", "in", "vivo", "affecting", "bone", "."], "h": {"id": "C3543418", "name": "C3543418#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541401", "name": "C3541401#ent", "pos": [14, 15]}}
{"token": ["A", "novel", "C1422492#ent", "<e1>", "was", "isolated", ",", "coactivator", "activator", "C1422492#ent", "<e1>", ")", ",", "that", "specifically", "associates", "with", "TRBP", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [2, 3]}}
{"token": ["These", "data", "suggest", "that", "C1422492#ent", "<e1>", "may", "serve", "as", "a", "mediator", "of", "C1422492#ent", "<e1>", "such", "as", "TRBP", "in", "gene", "activation"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [4, 5]}}
{"token": ["6-Azauracil", "inhibited", "the", "enzyme", "activity", "a", "Ki", "of", "approximately", "1.5", "mM.", "From", "the", "above", "properties", ",", "beta-alanine", "aminotransferase", "rabbit", "C0023899#ent", "<e1>", "was", "seen", "to", "closely", "resemble", "with", "C0002543#ent", "<e2>", "C0023899#ent", "<e1>", "and", "brain", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002543", "name": "C0002543#ent", "pos": [27, 28]}}
{"token": ["These", "results", "suggest", "that", "single-chain", "C1420314#ent", "<e1>", "secreted", "from", "follicular", "papilla", "cells", "converted", "to", "an", "active", "heterodimeric", "form", "by", "intrinsic", "C1420314#ent", "<e1>", "C1422492#ent", "<e1>", "and", "that", "the", "resultant", "active", "form", "C1420314#ent", "<e1>", "stimulates", "hair", "growth"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [5, 6]}}
{"token": ["Our", "data", "suggest", "that", "activation", "of", "the", "insulin", "receptor", "pathway", "inactivation", "of", "DCC", "and", "C1311257#ent", "<e1>", "may", "cooperate", "in", "malignant", "transformation", "BEP2D", "cells", "induced", "by", "C0003949#ent", "<e2>", "."], "h": {"id": "C1311257", "name": "C1311257#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003949", "name": "C0003949#ent", "pos": [25, 26]}}
{"token": ["C0022679#ent", "<e1>", "ranging", "from", "simple", "cysts", "to", "C2936739#ent", "<e2>", "polycystic", "kidney", "disease", "ADPKD", ")", ",", "can", "lead", "to", "significant", "complications", "such", "as", "pain", ",", "hypertension", ",", "infection", ",", "upper", "urinary", "tract", "obstruction", "and", "even", "renal", "failure"], "h": {"id": "C0022679", "name": "C0022679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [7, 8]}}
{"token": ["Increased", "GLUT2", "protein", "content", ",", "C1415014#ent", "<e1>", "mRNA", ",", "and", "glucose-6-phosphate", "in", "C2982484#ent", "<e2>", "null", "mice", "provide", "substrate", "for", "the", "enhanced", "fatty", "acid", "synthesis", "."], "h": {"id": "C1415014", "name": "C1415014#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [12, 13]}}
{"token": ["By", "his", "side", ",", "C0024790#ent", "<e1>", "demonstrated", "the", "transmission", "of", "C0024530#ent", "<e2>", "man", "to", "man", "by", "the", "blood", "of", "the", "sick", ",", "through", "experiences", "to", "day", "inadmissible", "for", "any", "ethical", "committee"], "h": {"id": "C0024790", "name": "C0024790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [10, 11]}}
{"token": ["The", "PKC", "activator", "phorbol", "12-myristate", "13-acetate", "PMA", ")", ",", "promoted", "a", "C0001477#ent", "<e1>", "influx", "that", "was", "significantly", "attenuated", "by", "C0054537#ent", "<e2>", "La(3", "+", ")", "but", "not", "by", "diltiazem", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0054537", "name": "C0054537#ent", "pos": [19, 20]}}
{"token": ["Although", "the", "activation", "of", "protein", "kinase", "C", "PKC", ")", "was", "observed", "during", "the", "C0001477#ent", "<e1>", "transients", ",", "neither", "a", "selective", "PKC", "inhibitor", "C0054537#ent", "<e2>", "nor", "a", "PKC", "activator", "PMA", ")", "changed", "the", "degrees", "of", "rundown", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0054537", "name": "C0054537#ent", "pos": [22, 23]}}
{"token": ["During", "this", "period", "C0022408#ent", "<e1>", "twice", "(", "0.12", "%", ")", "and", "C0003869#ent", "<e2>", "(", "0.024", "%", ")", "."], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0003869", "name": "C0003869#ent", "pos": [11, 12]}}
{"token": ["Regarding", "of", "microbiological", "aspects", "arthritis", "three", "forms", "of", "C0022408#ent", "<e1>", "under", "investigation", ":", "the", "C0003869#ent", "<e2>", "the", "reactive", "arthritis", "the", "Rheumatoid", "Arthritis"], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0003869", "name": "C0003869#ent", "pos": [14, 15]}}
{"token": ["This", "study", "examined", "the", "risk", "of", "a", "CVE", "in", "patients", "diagnosed", "with", "Alzheimer", "or", "C0011269#ent", "<e1>", "being", "treated", "with", "SGA", ",", "first-generation", "antipsychotics", ",", "or", "no", "C0040615#ent", "<e2>"], "h": {"id": "C0011269", "name": "C0011269#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [26, 27]}}
{"token": ["Marked", "staining", "of", "capillaries", "and", "venules", "with", "PAL-E", "was", "observed", "in", "the", "conjunctiva", ",", "C0014583#ent", "<e1>", ",", "sclera", ",", "ciliary", "processes", "choriocapillaris", "and", "C0029128#ent", "<e2>"], "h": {"id": "C0014583", "name": "C0014583#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029128", "name": "C0029128#ent", "pos": [23, 24]}}
{"token": ["The", "cells", "were", "cultured", "with", "increasing", "concentrations", "of", "FSH", ",", "with", "or", "without", "diethylstilbestrol", "(", "C0394006#ent", "<e1>", ")", "or", "various", "C0014930#ent", "<e2>", "."], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014930", "name": "C0014930#ent", "pos": [20, 21]}}
{"token": ["C0394006#ent", "<e1>", ",", "EE", ",", "and", "the", "three", "C0014930#ent", "<e2>", "each", "increased", "luminal", "epithelium", "hypertrophy", "to", "over", "3-fold", "above", "that", "in", "controls", "."], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014930", "name": "C0014930#ent", "pos": [8, 9]}}
{"token": ["The", "C0044602#ent", "<e1>", "wortmannin", "and", "LY294002", "inhibited", "basolateral", "to", "apical", "transport", "C1414557#ent", "<e2>", "more", "than", "apical", "to", "basolateral", "transport", "suggesting", "that", "there", "are", "differences", "in", "the", "mechanisms", "of", "transport", "in", "the", "two", "directions", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414557", "name": "C1414557#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "C0030956#ent", "<e1>", "the", "activities", "of", "superoxide", "dismutase", "SOD", ")", ",", "alkaline", "phosphatase", "C1427121#ent", "<e2>", ")", "and", "tyrosinase", "were", "studied", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1427121", "name": "C1427121#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", "RAGE", "and", "its", "ligands", "are", "increased", "in", "the", "vitreous", "cavity", "of", "C0235267#ent", "<e1>", "with", "PDR", "and", "C1419141#ent", "<e2>", "and", "are", "present", "in", "ERMs", "of", "C0235267#ent", "<e1>", "with", "these", "proliferative", "retinal", "disorders"], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419141", "name": "C1419141#ent", "pos": [19, 20]}}
{"token": ["We", "previously", "reported", "that", "receptor-mediated", "specific", "phagocytosis", "of", "C0289313#ent", "<e1>", "induces", "expression", "of", "C1705964#ent", "<e2>", "coding", "for", "transcription", "factors"], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705964", "name": "C1705964#ent", "pos": [13, 14]}}
{"token": ["In", "an", "experimental", "model", "glomerulonephritis", "in", "rats", "we", "found", "increased", "C1418888#ent", "<e1>", "and", "fibronectin", "synthesis", "cultured", "C0017658#ent", "<e2>", "which", "was", "greatly", "reduced", "by", "addition", "of", "antiserum", "to", "TGF-beta", "1"], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [16, 17]}}
{"token": ["Glomerular", "histology", "mesangial", "matrix", "expansion", "with", "a", "time", "course", "roughly", "paralleled", "that", "of", "the", "elevated", "C1418888#ent", "<e1>", "synthesis", "by", "the", "C0017658#ent", "<e2>", "increased", "."], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [20, 21]}}
{"token": ["All", "patients", "received", "concomitant", "therapy", "with", "hydroxyzine", "hydrochloride", "C0008783#ent", "<e1>", "to", "minimize", "C0042109#ent", "<e2>", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [12, 13]}}
{"token": ["Intravenous", "C0008783#ent", "<e1>", "treatment", "was", "prescribed", "for", "patients", "suffering", "from", "anaphylaxis", ",", "C0042109#ent", "<e2>", ",", "pruritus", ",", "and", "contact", "dermatitis"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [12, 13]}}
{"token": ["Our", "results", "indicate", "that", "C0008783#ent", "<e1>", "is", "efficacious", "as", "the", "initial", "treatment", "of", "C0042109#ent", "<e2>", "has", "less", "tendency", "toward", "sedation.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [13, 14]}}
{"token": ["Orally", "administered", "C0008783#ent", "<e1>", "significantly", "inhibited", "the", "induction", "of", "C0042109#ent", "<e2>", ",", "but", "H1", "antihistamines", "not", "suppress", "the", "weal", "formation", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [9, 10]}}
{"token": ["Coexpression", "with", "beta1a", ",", "beta1b", ",", "C1420841#ent", "<e1>", ",", "and", "beta4", ",", "yielded", "faster-inactivating", "C1413246#ent", "<e2>", "+", "currents", "than", "currents", "recorded", "from", "the", "alpha1E", "subunit", "alone", "."], "h": {"id": "C1420841", "name": "C1420841#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413246", "name": "C1413246#ent", "pos": [14, 15]}}
{"token": ["Transfection", "of", "GPR30", "into", "MDA-MB-231", "cells", "restores", "their", "ability", "to", "stimulate", "C1382029#ent", "<e1>", "attenuate", "EGF-induced", "activation", "of", "C4082284#ent", "<e2>", "by", "estrogen", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [17, 18]}}
{"token": ["The", "binding", "of", "calcitonin", "gene-related", "peptide", "CGRP", ")", "to", "L6", "myocytes", "the", "coupling", "of", "this", "receptor", "to", "C1382029#ent", "<e1>", "the", "resultant", "effects", "on", "C4082284#ent", "<e2>", "2-deoxyglucose", "uptake", "were", "examined", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [23, 24]}}
{"token": ["This", "G-protein-coupled", "receptor", "been", "shown", "to", "be", "functionally", "coupled", "to", "inhibition", "of", "C1382029#ent", "<e1>", "modulation", "of", "ion", "channels", "and", "activation", "of", "C4082284#ent", "<e2>"], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [21, 22]}}
{"token": ["C0909442#ent", "<e1>", "showed", "no", "effects", "the", "basal", "Ca2", "+", "concentration", "and", "NMDA-induced", "C1413043#ent", "<e2>", "+", "influx", "by", "itself", "PCP", "and", "SKF-10047", "reduced", "the", "NMDA-induced", "increase", "in", "intracellular", "C1413043#ent", "<e2>", "+", "concentration", "."], "h": {"id": "C0909442", "name": "C0909442#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["We", "show", "that", "two", "critical", "enzymes", "of", "long", "chain", "fatty", "acid", "metabolism", "C0085889#ent", "<e1>", "LCHAD", ")", "and", "C0000404#ent", "<e2>", "SCHAD", ")", ",", "are", "active", "in", "the", "normal", "human", "placenta", "."], "h": {"id": "C0085889", "name": "C0085889#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0000404", "name": "C0000404#ent", "pos": [17, 18]}}
{"token": ["Although", "there", "are", "numerous", "reports", "on", "olfactory", "deficits", "C1285162#ent", "<e1>", "olfactory", "function", "not", "been", "investigated", "in", "C0025517#ent", "<e2>", "presenting", "with", "extrapyramidal", "features"], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "we", "investigated", "the", "biological", "function", "mgl-1", ",", "a", "mouse", "orthologue", "of", "C0024054#ent", "<e1>", ",", "in", "the", "absence", "of", "Saccharomyces", "cerevisiae", "Sop1", "and", "C1705153#ent", "<e2>", ",", "the", "yeast", "homologues", "the", "C0024054#ent", "<e1>", "recessive", "oncogene"], "h": {"id": "C0024054", "name": "C0024054#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705153", "name": "C1705153#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "demonstrated", "that", "the", "cleavage", "of", "aggregable", "C1412277#ent", "<e1>", "occurred", "in", "concrete", "peptide", "bonds", "the", "CS-1", "and", "C1422182#ent", "<e2>", "attachment", "domains", "."], "h": {"id": "C1412277", "name": "C1412277#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422182", "name": "C1422182#ent", "pos": [18, 19]}}
{"token": ["The", "rAM-induced", "cAMP", "response", "was", "unaffected", "by", "C0033497#ent", "<e1>", ",", "indomethacin", ",", "or", "C0034403#ent", "<e2>", ",", "but", "inhibited", "by", "a", "CGRP", "receptor", "antagonist", ",", "human", "CGRP[8", "-", "37", "]", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034403", "name": "C0034403#ent", "pos": [13, 14]}}
{"token": ["Striatal", "implantation", "the", "PAR-1-activating", "peptide", "induced", "C0014070#ent", "<e1>", "neurobehavioral", "deficits", "mice", "compared", "with", "mice", "implanted", "with", "the", "C0030956#ent", "<e2>", "saline", "."], "h": {"id": "C0014070", "name": "C0014070#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}}
{"token": ["In", "vivo", "experiments", "confirmed", "that", "the", "HHQK", "peptide", "reduces", "rat", "C0014070#ent", "<e1>", "after", "infusion", "of", "Abeta", "C0030956#ent", "<e2>", "or", "implantation", "of", "native", "plaque", "fragments", "."], "h": {"id": "C0014070", "name": "C0014070#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}}
{"token": ["Rats", "were", "treated", "daily", "4", "wk", "with", "vehicle", "(", "C4284744#ent", "<e1>", ";", "olive", "oil", "1", "ml/kg", "sc", ")", "or", "C0751039#ent", "<e2>", "(", "15", "mg/kg", "sc", ")", "."], "h": {"id": "C4284744", "name": "C4284744#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [19, 20]}}
{"token": ["5", "of", "the", "9", ",", "case", "3", ",", "6", "-", "9", "all", "appeared", "with", "the", "symptoms", "of", "C0031117#ent", "<e1>", "case", "7", "also", "complicated", "with", "C0007286#ent", "<e2>"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [24, 25]}}
{"token": ["mPet-1", "is", "a", "member", "of", "the", "C0812327#ent", "<e1>", "its", "rat", "homologue", "C3273437#ent", "<e2>", "and", "the", "human", "homologue", "FEV", "."], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [11, 12]}}
{"token": ["Although", "statins", "have", "been", "reported", "to", "inhibit", "the", "prepro-endothelin-1", "(", "C3273437#ent", "<e1>", ")", "C0812327#ent", "<e2>", "endothelial", "cells", "their", "effects", "on", "the", "vascular", "function", "C3273437#ent", "<e1>", "have", "not", "been", "explored", "."], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [10, 11]}}
{"token": ["Monoclonal", "antibodies", "analysis", "of", "genomic", "and", "plasmid", "C0011522#ent", "<e1>", ",", "and", "the", "typing", "of", "C2350386#ent", "<e2>", "are", "suitable", "for", "this", "purpose", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2350386", "name": "C2350386#ent", "pos": [14, 15]}}
{"token": ["Only", "a", "small", "portion", "converted", "to", "the", "corresponding", "C0031607#ent", "<e1>", "was", "isomerized", "to", "1,3-DiC8", "before", "being", "C0025517#ent", "<e2>", "."], "h": {"id": "C0031607", "name": "C0031607#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [16, 17]}}
{"token": ["Curcumin", "almost", "completely", "blocked", "the", "effects", "of", "these", "irons", ",", "while", "minocycline", "and", "C0142846#ent", "<e1>", "suppressed", "the", "increased", "C1413931#ent", "<e2>", "mRNA", "level", "."], "h": {"id": "C0142846", "name": "C0142846#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413931", "name": "C1413931#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "case", "of", "chronic", "relapsing", "C0152025#ent", "<e1>", "six", "weeks", "after", "the", "onset", "of", "C0751401#ent", "<e2>"], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751401", "name": "C0751401#ent", "pos": [15, 16]}}
{"token": ["C0812198#ent", "<e1>", "and", "BAK", "formed", "a", "protein", "complex", "the", "cytosolic", "domain", "C1414444#ent", "<e2>", "that", "was", "essential", "for", "C1414444#ent", "<e2>", "activation", "."], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414444", "name": "C1414444#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C0812198#ent", "<e1>", "and", "BAK", "function", "at", "the", "ER", "membrane", "activate", "C1414444#ent", "<e2>", "signaling", "and", "to", "provide", "a", "physical", "link", "members", "of", "the", "core", "apoptotic", "pathway", "the", "UPR", "."], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414444", "name": "C1414444#ent", "pos": [12, 13]}}
{"token": ["In", "Ewing's", "sarcoma", "family", "tumors", "the", "ets", "transcription", "factor", "gene", "FLI1", "is", "rearranged", "with", "one", "C0808901#ent", "<e1>", "allele", "resulting", "in", "coexpression", "of", "germline", "C0808901#ent", "<e1>", "and", "chimeric", "C0908880#ent", "<e1>"], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [15, 16]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0908880", "name": "C0908880#ent", "pos": [27, 28]}}
{"token": ["Therefore", ",", "development", "of", "C1519837#ent", "<e1>", "cell", "injury", "induced", "by", "C1418392#ent", "<e2>", "would", "represent", "a", "new", "approach", "to", "finding", "new", "drugs", "that", "protect", "the", "heart", "against", "ischemic", "injury"], "h": {"id": "C1519837", "name": "C1519837#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418392", "name": "C1418392#ent", "pos": [10, 11]}}
{"token": ["Focal", "segmental", "glomerulosclerosis", "nephrotic", "syndrome", "C0022661#ent", "<e1>", "associated", "with", "spondyloepiphyseal", "dysplasia", "growth", "failure", "lymphopenia", "and", "transient", "C0007787#ent", "<e2>", "to", "severe", "neurological", "symptoms", "three", "children", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [16, 17]}}
{"token": ["These", "data", "provide", "morphologic", "support", "for", "a", "role", "of", "C0022661#ent", "<e1>", "in", "the", "pathophysiology", "of", "C0007787#ent", "<e2>"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [15, 16]}}
{"token": ["This", "study", "investigated", "the", "involvement", "of", "corticotrophin-releasing", "factor", "C0022661#ent", "<e1>", ")", "in", "acute", "neuronal", "damage", "induced", "by", "C0007787#ent", "<e2>", "pharmacological", "activation", "NMDA", "receptors", "the", "rat", "brain", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "present", "data", "suggesting", "that", "C1412515#ent", "<e1>", "physically", "associates", "with", "ARL2", ",", "the", "J-domain", "co-chaperone", "C1415764#ent", "<e2>", ",", "and", "actin", "in", "vivo"], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415764", "name": "C1415764#ent", "pos": [16, 17]}}
{"token": ["C0949646#ent", "<e1>", "binds", "both", "tPA", "and", "C1367553#ent", "<e2>", ",", "and", "enhances", "activation", "of", "des1", "-", "77-plasminogen", "by", "tPA", "but", "not", "by", "urokinase-type", "plasminogen", "activator", "uPA", ")", "."], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [6, 7]}}
{"token": ["C1831800#ent", "<e1>", ",", "a", "new", "C0015520#ent", "<e2>", "inhibitor", "is", "used", "as", "prophylaxis", "for", "venous", "thromboembolism", "VTE", ")", ",", "a", "well-known", "risk", "after", "orthopaedic", "surgery"], "h": {"id": "C1831800", "name": "C1831800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015520", "name": "C0015520#ent", "pos": [5, 6]}}
{"token": ["The", "inward", "current", "elicited", "by", "C0163872#ent", "<e1>", "was", "unaffected", "by", "K+", "channel", "blockade", "with", "external", "Cs+", ",", "C3539699#ent", "<e2>", "+", "or", "TEA", "."], "h": {"id": "C0163872", "name": "C0163872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [17, 18]}}
{"token": ["A", "recent", "report", "described", "a", "proximal", "C1417132#ent", "<e1>", "resembling", "partial", "conduction", "block", "in", "a", "patient", "with", "C0154743#ent", "<e2>", "the", "elbow", "(", "UNE", ")", "."], "h": {"id": "C1417132", "name": "C1417132#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0154743", "name": "C0154743#ent", "pos": [16, 17]}}
{"token": ["Twenty-one", "patients", "with", "C0038013#ent", "<e1>", "injections", "of", "either", "40", "mg", "or", "80", "mg", "of", "C0600901#ent", "<e2>", "one", "or", "both", "knee", "joints"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0600901", "name": "C0600901#ent", "pos": [14, 15]}}
{"token": ["Eighty", "adult", "patients", "with", "classical", "or", "definite", "C0038013#ent", "<e1>", "given", "200", "bolus", "injections", "of", "intramuscular", "C0600901#ent", "<e2>", "MPA", ")", "over", "four", "years", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0600901", "name": "C0600901#ent", "pos": [15, 16]}}
{"token": ["When", "subdivided", ",", "C1420508#ent", "<e1>", "subjects", "with", "an", "C0015371#ent", "<e2>", "more", "brainstem", "atrophy", "less", "cortical", "atrophy", "CBD", "subjects", "with", "an", "C0015371#ent", "<e2>"], "h": {"id": "C1420508", "name": "C1420508#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [8, 9]}}
{"token": ["Hyoscine", "(", "C0036442#ent", "<e1>", ")", ",", "which", "is", "effective", "in", "the", "prophylaxis", "of", "C0026603#ent", "<e2>", "shows", "similar", "binding", "affinities", "to", "all", "of", "the", "five", "known", "muscarinic", "receptor", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [2, 3]}, "relation": "may_prevent", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [13, 14]}}
{"token": ["A", "dermatomyositis-like", "eruption", "has", "not", "previously", "been", "reported", "to", "occur", "as", "a", "consequence", "of", "C0020402#ent", "<e1>", "treatment", "for", "C0033860#ent", "<e2>", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [18, 19]}}
{"token": ["Because", "of", "its", "systemic", "effects", "C0020402#ent", "<e1>", "is", "also", "used", "in", "the", "treatment", "of", "polycythemia", "and", "C0033860#ent", "<e2>", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [16, 17]}}
{"token": ["However", ",", "DNA", "sequence", "variation", "at", "two", "rapidly", "evolving", "unlinked", "nuclear", "loci", "C0024744#ent", "<e1>", "Mpi", ")", "and", "C0041078#ent", "<e2>", "Tpi", ")", ",", "show", "that", "the", "comimetic", "species", "have", "quite", "different", "quaternary", "demographies", "."], "h": {"id": "C0024744", "name": "C0024744#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041078", "name": "C0041078#ent", "pos": [17, 18]}}
{"token": ["Other", "C0016018#ent", "<e1>", "under", "study", ",", "including", "antithrombin", "III", "C1170000#ent", "<e2>", "although", "only", "the", "latter", "has", "demonstrated", "a", "benefit", "in", "terms", "of", "survival", "in", "a", "comparative", ",", "randomized", "context", "."], "h": {"id": "C0016018", "name": "C0016018#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1170000", "name": "C1170000#ent", "pos": [9, 10]}}
{"token": ["Other", "new", "C0016018#ent", "<e1>", "the", "antithrombin", "III-independent", "factor", "Xa", "inhibitors", ",", "C1170000#ent", "<e2>", "soluble", "thrombomodulin", "and", "tissue", "factor", "pathway", "inhibitor", "."], "h": {"id": "C0016018", "name": "C0016018#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1170000", "name": "C1170000#ent", "pos": [11, 12]}}
{"token": ["A", "case", "of", "C0338451#ent", "<e1>", "parkinsonism", "(", "FTDP", ")", "similar", "to", "progressive", "supranuclear", "palsy", "C1420508#ent", "<e2>", ")", "was", "reported", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420508", "name": "C1420508#ent", "pos": [14, 15]}}
{"token": ["Thirty-five", "patients", "(", "14", "C0338451#ent", "<e1>", ",", "11", "CBD", "and", "10", "C1420508#ent", "<e2>", ")", "and", "20", "controls", "were", "recruited", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420508", "name": "C1420508#ent", "pos": [11, 12]}}
{"token": ["We", "have", "studied", "the", "beneficial", "effects", "of", "S-adenosyl-L-methionine", "(SAM)", "tosylate", "blood-brain", "barrier", "C1801950#ent", "<e1>", ")", "breakdown", "and", "C1420257#ent", "<e2>", "transient", "cerebral", "ischemia", "gerbils", "."], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [17, 18]}}
{"token": ["This", "research", "indicates", "a", "pathway", "whereby", "immune", "signals", "may", "be", "communicated", "to", "the", "CNS", "and", "has", "revealed", "one", "way", "that", "the", "C1801950#ent", "<e1>", "may", "protect", "C1420257#ent", "<e2>", "challenge", "conditions", "."], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [25, 26]}}
{"token": ["These", "results", "provide", "genetic", "evidence", "C3539645#ent", "<e1>", "mediates", "some", "of", "the", "effects", "of", "c-H-ras", "C1417123#ent", "<e2>", "on", "cell", "transformation"], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [14, 15]}}
{"token": ["Phospho-ARPP-21", "was", "dephosphorylated", "effectively", "by", "C0031686#ent", "<e1>", "-2A", ",", "but", "not", "by", "C0054450#ent", "<e2>", "-2C", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0054450", "name": "C0054450#ent", "pos": [12, 13]}}
{"token": ["The", "diagnosis", "of", "C0033835#ent", "<e1>", "on", "clinical", ",", "radiological", "and", "C0235031#ent", "<e2>", "evocative", "dysmorphic", "syndrome", "absence", "of", "disturbances", "in", "the", "phosphocalcic", "metabolism"], "h": {"id": "C0033835", "name": "C0033835#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235031", "name": "C0235031#ent", "pos": [10, 11]}}
{"token": ["Similarly", ",", "oedema", "formation", "induced", "by", "PAF", "and", "lipopolysaccharide", "(", "C0175697#ent", "<e1>", ")", ",", "but", "not", "by", "zymosan-activated", "plasma", "(", "C1428222#ent", "<e2>", ")", ",", "was", "significantly", "inhibited", "by", "dexamethasone", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1428222", "name": "C1428222#ent", "pos": [20, 21]}}
{"token": ["We", "report", "3", "cases", "of", "benign", "retroperitoneal", "schwannoma", "of", "whom", "one", "presented", "with", "C0016199#ent", "<e1>", "hematuria", ",", "one", "presented", "with", "headache", "and", "C0155616#ent", "<e2>", "one", "presented", "with", "recurrent", "renal", "colicky", "pain"], "h": {"id": "C0016199", "name": "C0016199#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0155616", "name": "C0155616#ent", "pos": [22, 23]}}
{"token": ["To", "address", "this", "question", ",", "we", "generated", "truncated", "mutants", "of", "C1721358#ent", "<e1>", "various", "deletions", "in", "the", "COOH-terminal", "domain", "chimeric", "molecules", "C1721358#ent", "<e1>", "stromelysin", "and", "assayed", "the", "expressed", "C3540790#ent", "<e1>", "against", "type", "I", "collagen", "the", "general", "substrate", "casein", "."], "h": {"id": "C1721358", "name": "C1721358#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [27, 28]}}
{"token": ["Herpes", "simplex", "virus", "infections", "well", "known", "complications", "of", "various", "C0018567#ent", "<e1>", "and", "have", "also", "been", "reported", "in", "acantholytic", "diseases", "C0030809#ent", "<e2>", "Darier's", "Hailey-Hailey", "diseases"], "h": {"id": "C0018567", "name": "C0018567#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030809", "name": "C0030809#ent", "pos": [19, 20]}}
{"token": ["It", "has", "been", "recently", "evaluated", ",", "with", "varying", "results", ",", "in", "several", "C0018567#ent", "<e1>", "such", "as", "C0030809#ent", "<e2>"], "h": {"id": "C0018567", "name": "C0018567#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030809", "name": "C0030809#ent", "pos": [16, 17]}}
{"token": ["This", "C0027203#ent", "<e1>", "converts", "lysine", "into", "C0051243#ent", "<e2>", "and", "plays", "an", "important", "role", "in", "the", "biosynthesis", "of", "2-aminoadipic", "acid", "a", "precursor", "of", "penicillin", "and", "other", "beta-lactam", "antibiotics"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0051243", "name": "C0051243#ent", "pos": [6, 7]}}
{"token": ["Cultures", "of", "rat", "cerebellum", "grown", "on", "glass", "coverslips", "coated", "first", "with", "C0009356#ent", "<e1>", "and", "then", "C0009325#ent", "<e2>", "are", "fixed", "in", "glutaraldehyde", "to", "which", "ruthenium", "red", "been", "added", "."], "h": {"id": "C0009356", "name": "C0009356#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}}
{"token": ["This", "report", "describes", "the", "use", "of", "C0171023#ent", "<e1>", "in", "the", "treatment", "of", "a", "patient", "with", "C0162532#ent", "<e2>"], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162532", "name": "C0162532#ent", "pos": [15, 16]}}
{"token": ["We", "concluded", "that", "the", "C0720099#ent", "<e1>", "of", "PD", "appears", "to", "be", "the", "strongest", "predictor", "of", "C0086132#ent", "<e2>", "spouse-caregivers", "in", "this", "small", "cohort", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086132", "name": "C0086132#ent", "pos": [15, 16]}}
{"token": ["Dietary", "C0072954#ent", "<e1>", "did", "not", "affect", "adipose", "UCP2", "or", "C1421315#ent", "<e2>", "(", "P>0.05", ")", "."], "h": {"id": "C0072954", "name": "C0072954#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421315", "name": "C1421315#ent", "pos": [9, 10]}}
{"token": ["In", "a", "prospective", "study", "45", "patients", "with", "rheumatoid", "arthritis", "C1457887#ent", "<e1>", "signs", "were", "evaluated", "before", "and", "during", "treatment", "with", "intramuscular", "sodium", "aurothiomalate", "C0700008#ent", "<e2>", ")", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0700008", "name": "C0700008#ent", "pos": [22, 23]}}
{"token": ["Another", "family", "manifesting", "an", "C0678928#ent", "<e1>", ",", "reticulate", ",", "pigmentary", "dermatosis", ",", "previously", "C0740340#ent", "<e2>", "has", "been", "observed", "."], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0740340", "name": "C0740340#ent", "pos": [13, 14]}}
{"token": ["The", "C1366882#ent", "<e1>", "localized", "in", "nonjunctional", "regions", "C0238190#ent", "<e2>", "underlie", "the", "known", "pathological", "up-regulation", "of", "junctional", "proteins", "."], "h": {"id": "C1366882", "name": "C1366882#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0238190", "name": "C0238190#ent", "pos": [7, 8]}}
{"token": ["Infection", "was", "the", "commonest", "associated", "factor", "followed", "by", "hypotension", "and", "volume", "problems", ",", "C0600503#ent", "<e1>", "jaundice", "and", "hepatic", "failure", "respiratory", "failure", "pancreatitis", "and", "C0030528#ent", "<e2>"], "h": {"id": "C0600503", "name": "C0600503#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030528", "name": "C0030528#ent", "pos": [23, 24]}}
{"token": ["The", "C3273340#ent", "<e1>", "(", "MAL/VIP17", ")", "proteolipid", "is", "a", "C0021699#ent", "<e2>", "expressed", "in", "a", "restricted", "pattern", "of", "cell", "types", "including", "T", "lymphocytes", "myelin-forming", "cells", ",", "and", "polarized", "epithelial", "cells"], "h": {"id": "C3273340", "name": "C3273340#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [9, 10]}}
{"token": ["C1335834#ent", "<e1>", "ghosts", "do", "not", "exclude", "T4", ",", "T7", ",", "or", "C1739091#ent", "<e2>", "in", "Escherichia", "coli", "survive", "ghost", "infection", "."], "h": {"id": "C1335834", "name": "C1335834#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1739091", "name": "C1739091#ent", "pos": [11, 12]}}
{"token": ["Cutaneous", "pseudolymphomas", "erythema", "chronicum", "migrans", "Afzelius", ",", "acrodermatitis", "chronica", "atrophicans", "Pick-Herxheimer", ",", "meningo-radiculitis", "and", "various", "C0152087#ent", "<e1>", "are", "the", "most", "commonly", "encountered", "C0012634#ent", "<e2>", "."], "h": {"id": "C0152087", "name": "C0152087#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}}
{"token": ["Besides", "C0152087#ent", "<e1>", "the", "most", "frequent", "cause", "of", "recurrent", "arthritis", "there", "are", "several", "C0012634#ent", "<e2>", "that", "may", "present", "clinically", "as", "intermittent", "mono-", "or", "polyarthritis", "."], "h": {"id": "C0152087", "name": "C0152087#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggested", "that", "a", "combination", "of", "granisetron", "and", "C0038317#ent", "<e1>", "was", "useful", "for", "preventing", "CDDP-based", "combination", "C0549410#ent", "<e2>"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0549410", "name": "C0549410#ent", "pos": [17, 18]}}
{"token": ["In", "PC12", "cells", "expressing", "alpha(1A)-adrenergic", "receptors", "(", "ARs", ")", ",", "C3887648#ent", "<e1>", "(", "NE", ")", "activates", "several", "C0170168#ent", "<e2>", "causes", "differentiation", "(", ")", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "in", "such", "women", ",", "medical", "adrenalectomy", "likely", "to", "produce", "an", "incomplete", "suppression", "of", "plasma", "C0002842#ent", "<e1>", ",", "but", "its", "combination", "with", "C0149473#ent", "<e2>", "may", "provide", "a", "new", "therapeutic", "option", "."], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0149473", "name": "C0149473#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "report", "that", "the", "C0171196#ent", "<e1>", "Aag", ")", ",", "an", "C0027203#ent", "<e2>", "that", "initiates", "base", "excision", "repair", "a", "variety", "of", "alkylated", "bases", "is", "also", "involved", "in", "the", "repair", "of", "ICLs", "."], "h": {"id": "C0171196", "name": "C0171196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["As", "well", ",", "diagnostic", "criteria", "treatment", "of", "C1335283#ent", "<e1>", "resemble", "that", "of", "C0149521#ent", "<e2>", "other", "causes", "."], "h": {"id": "C1335283", "name": "C1335283#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [12, 13]}}
{"token": ["Hereditary", "chronic", "pancreatitis", "C1335283#ent", "<e1>", ")", "is", "a", "very", "rare", "form", "of", "early", "onset", "C0149521#ent", "<e2>"], "h": {"id": "C1335283", "name": "C1335283#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [14, 15]}}
{"token": ["Diagnostic", "criteria", "treatment", "of", "C1335283#ent", "<e1>", "also", "resemble", "those", "of", "C0149521#ent", "<e2>", "other", "causes", "."], "h": {"id": "C1335283", "name": "C1335283#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [10, 11]}}
{"token": ["Claritromycin", "is", "also", "indicated", "for", "C0024959#ent", "<e1>", "uncomplicated", "skin", "and", "skin", "structure", "infections", "pneumonia", "and", "C0026918#ent", "<e2>"], "h": {"id": "C0024959", "name": "C0024959#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [15, 16]}}
{"token": ["Some", "non-ionic", "surfactants", ",", "including", "C0146951#ent", "<e1>", "Cutscum", ",", "and", "some", "anionic", "surfactants", "including", "sodium", "taurocholate", "C0037506#ent", "<e2>", "phosphatidylinositol", "and", "N-dodecylsarcosinate", ",", "were", "able", "to", "replace", "the", "hexosaminidase", "A-activator", "protein", "Hechtman", "(", "1977", ")", "Can", "."], "h": {"id": "C0146951", "name": "C0146951#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [16, 17]}}
{"token": ["Two", "types", "of", "opsin", "were", "prepared", "from", "purified", "bovine", "retina", "outer", "segments", ",", "one", "type", "in", "C0146951#ent", "<e1>", "the", "other", "in", "C0037506#ent", "<e2>"], "h": {"id": "C0146951", "name": "C0146951#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [21, 22]}}
{"token": ["C0017837#ent", "<e1>", "GST", ")", "catalyses", "the", "nucleophilic", "addition", "of", "the", "C0599532#ent", "<e2>", "of", "GST", "to", "electrophilic", "acceptors"], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [10, 11]}}
{"token": ["Our", "data", "suggest", "that", "the", "active", "site", "the", "bacterial", "enzyme", "intermediate", "properties", "those", "of", "the", "recently", "evolved", "C0017837#ent", "<e1>", "those", "of", "the", "C0599532#ent", "<e2>", ":", "disulfide", "oxidoreductase", "superfamily"], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [22, 23]}}
{"token": ["In", "response", "to", "DNA", "strand", "breaks", "C1336660#ent", "<e1>", "phosphorylation", "depends", "on", "the", "ataxia", "telangiectasia", "mutated", "protein", "C0004135#ent", "<e2>", ")", "in", "vivo"], "h": {"id": "C1336660", "name": "C1336660#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [16, 17]}}
{"token": ["PML", "and", "C1336660#ent", "<e1>", "also", "colocalized", "with", "Rad50", ",", "Brca1", ",", "C0004135#ent", "<e2>", ",", "Rad9", ",", "and", "BLM", "."], "h": {"id": "C1336660", "name": "C1336660#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [11, 12]}}
{"token": ["C0268338#ent", "<e1>", "a", "heritable", "connective", "tissue", "disorder", "frequent", "neurovascular", "manifestations", "such", "as", "C0007766#ent", "<e2>"], "h": {"id": "C0268338", "name": "C0268338#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0007766", "name": "C0007766#ent", "pos": [12, 13]}}
{"token": ["We", "established", "a", "novel", "human", "myxofibrosarcoma", "cell", "line", "C1705360#ent", "<e1>", "and", "analyzed", "it", "with", "spectral", "karyotyping", "comparative", "genomic", "hybridization", "C1855900#ent", "<e2>", ")", "."], "h": {"id": "C1705360", "name": "C1705360#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1855900", "name": "C1855900#ent", "pos": [19, 20]}}
{"token": ["These", "activities", "were", "inhibited", "when", "C0258870#ent", "<e1>", "incubated", "with", "benzamidine", "or", "C0038623#ent", "<e2>", "."], "h": {"id": "C0258870", "name": "C0258870#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038623", "name": "C0038623#ent", "pos": [11, 12]}}
{"token": ["Exposure", "of", "these", "cells", "to", "OSM", "for", "30", "h", "increased", "C0872913#ent", "<e1>", "mRNA", "expression", "by", "20-fold", "and", "C1705527#ent", "<e2>", "mRNA", "expression", "by", "5-fold", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705527", "name": "C1705527#ent", "pos": [17, 18]}}
{"token": ["We", "performed", "a", "dose-finding", "study", "in", "human", "HD", "of", "C0718066#ent", "<e1>", "SPB", ")", ",", "a", "C0019643#ent", "<e2>", "inhibitor", "that", "ameliorates", "the", "HD", "phenotype", "in", "animal", "models"], "h": {"id": "C0718066", "name": "C0718066#ent", "pos": [9, 10]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [15, 16]}}
{"token": ["The", "full", "therapeutic", "potential", "of", "combined", "C0073992#ent", "<e1>", "plus", "an", "C0242896#ent", "<e2>", "therefore", "only", "be", "established", "using", "doses", "higher", "than", "those", "currently", "recommended", "in", "the", "marketing", "of", "these", "agents", "."], "h": {"id": "C0073992", "name": "C0073992#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [10, 11]}}
{"token": ["During", "subsequent", "weeks", ",", "C2239920#ent", "<e1>", "rhythms", "of", "nonlesioned", "C0014544#ent", "<e2>", "rats", "remained", "elevated", "but", "progressively", "normalized", "over", "a", "period", "of", "12", "weeks", "."], "h": {"id": "C2239920", "name": "C2239920#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [9, 10]}}
{"token": ["We", "report", "two", "patients", "with", "scleroderma", ",", "73-year-old", "female", "and", "67-year-old", "female", ",", "who", "developed", "anti", "neutrophil", "cytoplasmic", "autoantibody", "C1414527#ent", "<e1>", ")", "associated", "rapid", "C0017658#ent", "<e2>", "RPGN", ")", "."], "h": {"id": "C1414527", "name": "C1414527#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [24, 25]}}
{"token": ["This", "animal", "model", "strong", "support", "for", "a", "direct", "pathogenic", "role", "for", "C1414527#ent", "<e1>", "IgG", "in", "C0017658#ent", "<e2>", "vasculitis", "."], "h": {"id": "C1414527", "name": "C1414527#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [15, 16]}}
{"token": ["Radiation", "is", "thought", "to", "produce", "Erectile", "Dysfunction", "ED", ")", "by", "accelerating", "microvascular", "angiopathy", "C0030848#ent", "<e1>", "stenosis", "of", "the", "pelvic", "arteries", "by", "accelerating", "existing", "C0027719#ent", "<e2>", ",", "leading", "to", "vascular", "impotence"], "h": {"id": "C0030848", "name": "C0030848#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027719", "name": "C0027719#ent", "pos": [23, 24]}}
{"token": ["These", "results", "indicate", "that", "C0281603#ent", "<e1>", "potentiates", "the", "cytotoxic", "effect", "the", "C0729502#ent", "<e2>", "MMC", "by", "promoting", "drug-induced", "apoptosis", "tumor", "cells"], "h": {"id": "C0281603", "name": "C0281603#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "suggest", "that", "down-regulation", "of", "Bcl-2", "may", "be", "one", "of", "the", "molecular", "mechanisms", "which", "C0281603#ent", "<e1>", "induces", "apoptosis", "and", "inhibits", "cell", "growth", "suggesting", "that", "C0281603#ent", "<e1>", "may", "be", "an", "effective", "C0729502#ent", "<e1>", "prostate", "cancer"], "h": {"id": "C0281603", "name": "C0281603#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [31, 32]}}
{"token": ["Alcian", "blue", "stains", "pollen-tube", "walls", "intensely", "at", "the", "C1825626#ent", "<e1>", ",", "indicating", "that", "C0032594#ent", "<e2>", "concentrated", "in", "the", "C1825626#ent", "<e1>", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1825626", "name": "C1825626#ent", "pos": [8, 9]}}
{"token": ["Anaerobic", "growth", "Salmonella", "typhimurium", "C0376259#ent", "<e1>", "is", "Na+-dependent", "and", "requires", "induction", "of", "the", "necessary", "C3541394#ent", "<e2>", "during", "a", "20", "-", "40", "h", "lag", "phase"], "h": {"id": "C0376259", "name": "C0376259#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [14, 15]}}
{"token": ["The", "pharmacokinetic", "interactions", "between", "BAY", "12", "-", "9566", "and", "two", "nonsteroidal", "anti-inflammatory", "drugs", "NSAIDs", ")", ",", "naproxen", "and", "C0020740#ent", "<e1>", ",", "were", "investigated", "in", "C0029408#ent", "<e2>", "(", "OA", ")", "patients", "."], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [24, 25]}}
{"token": ["C0020740#ent", "<e1>", "has", "wide", "applications", "in", "the", "treatment", "of", "rheumatoid", "arthritis", "C0029408#ent", "<e2>", "as", "an", "effective", "non-steroidal", "antiinflammatory", "drug"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [11, 12]}}
{"token": ["We", "compared", "the", "efficacy", "of", "etoricoxib", "30", "mg", "to", "placebo", "and", "C0020740#ent", "<e1>", "2400", "mg", "for", "the", "treatment", "of", "C0029408#ent", "<e2>", "(", "OA", ")", "of", "the", "hip", "and", "knee", "."], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "confirm", "that", "this", "preparation", "of", "arnica", "is", "not", "inferior", "to", "C0020740#ent", "<e1>", "when", "treating", "C0029408#ent", "<e2>"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [16, 17]}}
{"token": ["Absolute", "C0001962#ent", "<e1>", "is", "useful", "as", "a", "sclerosing", "agent", "C0017145#ent", "<e2>", "and", "may", "produce", "a", "more", "permanent", "and", "distal", "occlusion", "gastroesophageal", "varices"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017145", "name": "C0017145#ent", "pos": [9, 10]}}
{"token": ["Hepatic", "sinusoidal", "lesions", "including", "C0030781#ent", "<e1>", "sinusoidal", "dilatation", ",", "are", "frequently", "observed", "during", "human", "C0001175#ent", "<e2>"], "h": {"id": "C0030781", "name": "C0030781#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [14, 15]}}
{"token": ["We", "report", "two", "cases", "of", "C0030781#ent", "<e1>", "patients", "with", "C0001175#ent", "<e2>"], "h": {"id": "C0030781", "name": "C0030781#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [9, 10]}}
{"token": ["In", "cardiomyocytes", "cultured", "on", "ECM", ",", "PE", "stimulated", "a", "rapid", "increase", "in", "tyrosine", "phosphorylation", "focal", "adhesion", "proteins", "C1565427#ent", "<e1>", ",", "paxillin", ",", "and", "C1423614#ent", "<e2>", "Crk-associated", "substrate", "and", "subsequent", "formation", "of", "peripheral", "focal", "complexes", "."], "h": {"id": "C1565427", "name": "C1565427#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1423614", "name": "C1423614#ent", "pos": [23, 24]}}
{"token": ["The", "phosphotyrosine", "content", "of", "C1565427#ent", "<e1>", ",", "paxillin", ",", "and", "C1423614#ent", "<e2>", "was", "also", "increased", "following", "stimulation", "with", "phorbol", "12-myristate", "13-acetate", "PMA", ")", "(", "0.1", "microM", ")", "."], "h": {"id": "C1565427", "name": "C1565427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423614", "name": "C1423614#ent", "pos": [10, 11]}}
{"token": ["From", "hydrophobicity", "analysis", "both", "cybL", "and", "C3273623#ent", "<e1>", "appear", "to", "have", "three", "C0021699#ent", "<e2>", "indicating", "their", "role", "as", "membrane-anchors", "for", "the", "enzyme", "complex"], "h": {"id": "C3273623", "name": "C3273623#ent", "pos": [6, 7]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [12, 13]}}
{"token": ["The", "presence", "of", "C1420679#ent", "<e1>", "was", "required", "for", "C1334533#ent", "<e2>", "overexpression", "as", "determined", "by", "C1420679#ent", "<e1>", "knockdown", "experiments", "."], "h": {"id": "C1334533", "name": "C1334533#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420679", "name": "C1420679#ent", "pos": [3, 4]}}
{"token": ["The", "C0072074#ent", "<e1>", "of", "C0527189#ent", "<e2>", "in", "42", "nonhistamine", "receptor", "binding", "assays", "that", "C0527189#ent", "<e2>", "interacts", "with", "only", "two", "nonhistamine", "receptor/uptake", "sites", "to", "any", "significant", "degree", "(", "pIC50", "<", "or", "=", "5", "-", "6", ")", "."], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0527189", "name": "C0527189#ent", "pos": [4, 5]}}
{"token": ["The", "most", "important", "manifestations", "of", "advanced", "liver", "disease", "C0022806#ent", "<e1>", ",", "encephalopathy", ",", "and", "C0043459#ent", "<e2>"], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "toxic", "effects", "organic", "anions", "characteristically", "appeared", "in", "the", "patients", "with", "progressive", "renal", "disease", "renal", "proximal", "C0151747#ent", "<e1>", "expressing", "human", "C1420141#ent", "<e2>", "hOAT", ")", "1", "."], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1420141", "name": "C1420141#ent", "pos": [26, 27]}}
{"token": ["At", "concentrations", "as", "high", "as", "1", "mM", ",", "C0044270#ent", "<e1>", "was", "inactive", "on", "these", "inotropic", "receptors", "either", "as", "C2987634#ent", "<e2>", "or", "as", "antagonist", "."], "h": {"id": "C0044270", "name": "C0044270#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [18, 19]}}
{"token": ["No", "mutations", "were", "identified", "in", "the", "entire", "coding", "area", "the", "ACTH", "receptor", "the", "2", "families", "with", "C0221033#ent", "<e1>", "supporting", "the", "idea", "of", "a", "developmental", "or", "postreceptor", "defect", "this", "C0039082#ent", "<e2>", "."], "h": {"id": "C0221033", "name": "C0221033#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [28, 29]}}
{"token": ["4", "cases", "of", "malignant", "melanoma", "identified", "by", "C0014921#ent", "<e1>", "basing", "on", "the", "C1420066#ent", "<e2>", "and", "melanosome", "in", "the", "cells", "."], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [12, 13]}}
{"token": ["C1257113#ent", "<e1>", "encoded", "by", "the", "C0079941#ent", "<e2>", "in", "introns", "or", "inteins", "of", "mobile", "genetic", "elements", "possess", "double-stranded", "DNA-specific", "endonuclease", "activity"], "h": {"id": "C1257113", "name": "C1257113#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [5, 6]}}
{"token": ["Estrogen-related", "receptors", "ERRs", ")", "are", "orphan", "nuclear", "receptors", "activated", "by", "the", "C4054191#ent", "<e1>", "PPARgamma", ")", "coactivator", "1alpha", "(", "C1418779#ent", "<e2>", ")", ",", "a", "critical", "regulator", "of", "cellular", "energy", "metabolism"], "h": {"id": "C4054191", "name": "C4054191#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [18, 19]}}
{"token": ["Neither", "coexpression", "of", "TLE1", "or", "C1420753#ent", "<e1>", "nor", "the", "absence", "of", "the", "TLE", "interaction", "motif", "of", "C2984559#ent", "<e2>", "(", "amino", "acids", "to", "513", ")", "influenced", "repressor", "activity"], "h": {"id": "C1420753", "name": "C1420753#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2984559", "name": "C2984559#ent", "pos": [16, 17]}}
{"token": ["The", "coordinated", "control", "found", "for", "the", "C1418544#ent", "<e1>", "and", "gdh", "genes", "is", "in", "good", "agreement", "with", "these", "C3541394#ent", "<e2>", "acting", "in", "a", "concerted", "manner", "to", "form", "an", "electron", "sink", "P.", "furiosus", "."], "h": {"id": "C1418544", "name": "C1418544#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["In", "chronic", "C0020934#ent", "<e1>", "rats", ",", "the", "hypomotility", "and", "sedative", "response", "low", "dose", "C0003596#ent", "<e2>", "challenge", "was", "significantly", "attenuated", "(", "P", "less", "than", "0.05", ")", ",", "as", "compared", "to", "saline", "treated", "controls", "."], "h": {"id": "C0020934", "name": "C0020934#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [13, 14]}}
{"token": ["These", "HDL", "modifications", "are", "accompanied", "with", "altered", "biological", "activities", "HDL", "and", "associated", "C3541394#ent", "<e1>", ",", "including", "paraoxonase", ",", "CETP", "and", "C1416804#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [20, 21]}}
{"token": ["This", "study", "examines", "the", "activity", "of", "two", "key", "C3541394#ent", "<e1>", "of", "reverse", "cholesterol", "transport", "cholesterol", "ester", "transfer", "protein", "CETP", ")", "and", "lecithin", ":", "cholesterol", "acyl", "transferase", "C1416804#ent", "<e2>", ")", "in", "21", "patients", "with", "non-insulin", "dependent", "diabetes", "mellitus", "NIDDM", ")", "and", "21", "control", "subjects"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [26, 27]}}
{"token": ["The", "elevation", "in", "plasma", "C2744579#ent", "<e1>", "level", "correlates", "with", "the", "serum", "creatinine", "C1561643#ent", "<e2>", "patients", "not", "on", "dialysis", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "demonstrate", "basal", "state", "binding", "of", "C2744579#ent", "<e1>", "to", "the", "C1561643#ent", "<e2>", "leading", "to", "cis-autophosphorylation", "and", "novel", "basal", "state", "interactions", "among", "the", "subdomains", "of", "the", "insulin", "receptor", "kinase"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [11, 12]}}
{"token": ["Both", "C0381060#ent", "<e1>", "and", "ABT-431", "(", "(-)-trans-9,10-diacetyloxy-2-propyl-4,5,5a,6,7,11b-", "hexahydro-3-thia-5-azacyclopent-1-ena[c]phenanthrene", "hydrochloride", ")", ",", "the", "C0000997#ent", "<e2>", "prodrug", "derivative", "of", "C0381060#ent", "<e1>", ",", "were", "evaluated", "for", "their", "effects", "on", "behavioral", "excitability", "in", "rodents", "."], "h": {"id": "C0000997", "name": "C0000997#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0381060", "name": "C0381060#ent", "pos": [1, 2]}}
{"token": ["These", "effects", "were", "reverted", "by", "p38", "MAPK", "inhibitor", "C0297666#ent", "<e1>", "as", "well", "as", "by", "blocking", "C0379099#ent", "<e2>", "bafilomycin", "A(1", ")", "."], "h": {"id": "C0297666", "name": "C0297666#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [15, 16]}}
{"token": ["LC-MS/MS", "analysis", "of", "S.", "laete-viridis", "fractions", "established", "the", "co-occurrence", "of", "C2355200#ent", "<e1>", "1", ")", "and", "its", "C1334043#ent", "<e2>", "2", ")", ",", "which", "was", "previously", "reported", "in", "low", "yield", "from", "the", "sea", "hare", "Dolabella", "auricularia"], "h": {"id": "C2355200", "name": "C2355200#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}}
{"token": ["C1442514#ent", "<e1>", "(", "MAPK-activated", "protein", "kinase-2", "phosphorylated", "bacterially", "expressed", "full-length", "human", "C1414333#ent", "<e2>", "at", "serine-387", "in", "vitro", "but", "not", "the", "S387A", "mutant", "."], "h": {"id": "C1442514", "name": "C1442514#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414333", "name": "C1414333#ent", "pos": [11, 12]}}
{"token": ["Dosage", "forms", "were", "C0031681#ent", "<e1>", "75", "mg", "sustained-release", "(", "SR", ")", ",", "C0031681#ent", "<e1>", "SR", "75", "mg", "with", "caffeine", "200", ",", "C0993287#ent", "<e1>", "and", "placebo", "."], "h": {"id": "C0031681", "name": "C0031681#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0993287", "name": "C0993287#ent", "pos": [21, 22]}}
{"token": ["To", "investigate", "the", "effects", "of", "C0677666#ent", "<e1>", "high", "calcium", "intake", "the", "concentration", "of", "serum", "total", "cholesterol", "C3272447#ent", "<e2>", ")", "and", "serum", "lipids", "hypercholesterolemic", "rats", "."], "h": {"id": "C0677666", "name": "C0677666#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3272447", "name": "C3272447#ent", "pos": [16, 17]}}
{"token": ["The", "new", "C0991617#ent", "<e1>", ",", "LZ", ",", "Q/D", "and", "C1418829#ent", "<e2>", ",", "proved", "to", "be", "effective", "against", "both", ",", "S.", "aureus", "S.", "pneumoniae"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418829", "name": "C1418829#ent", "pos": [9, 10]}}
{"token": ["We", "assessed", "the", "etiology", "and", "the", "prevalence", "of", "C1704436#ent", "<e1>", "venous", "disease", "leg", "ulcers", "patients", "with", "C0003873#ent", "<e2>", "systemic", "sclerosis", "analyzed", "the", "outcome", "after", "treatment", "of", "macrovascular", "disease"], "h": {"id": "C1704436", "name": "C1704436#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["Examples", "of", "C3889446#ent", "<e1>", "genes", "are", "SFRP1", "that", "is", "involved", "in", "Wnt", "signalling", "C1367148#ent", "<e2>", ",", "which", "is", "of", "importance", "for", "fetal", "growth", "inhibits", "cell", "growth", "insulin-like", "growth", "factor-II"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1367148", "name": "C1367148#ent", "pos": [13, 14]}}
{"token": ["C0669938#ent", "<e1>", "DRPs", ")", "compose", "a", "diverse", "family", "of", "C0086376#ent", "<e2>", "that", "function", ",", "through", "GTPase", "stimulated", "self-assembly", ",", "to", "remodel", "cellular", "membranes"], "h": {"id": "C0669938", "name": "C0669938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["C0669938#ent", "<e1>", "a", "large", "C0086376#ent", "<e2>", "has", "recently", "been", "cloned", ",", "and", "studies", "have", "suggested", "that", "it", "is", "involved", "in", "the", "formation", "of", "coated", "vesicles"], "h": {"id": "C0669938", "name": "C0669938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}}
{"token": ["Down-regulation", "of", "C1421451#ent", "<e1>", "and", "a", "C1449387#ent", "<e2>", "up-regulation", "of", "ferritin", "heavy", "chain", "confirmed", "by", "Northern", "blot", "analysis"], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1449387", "name": "C1449387#ent", "pos": [6, 7]}}
{"token": ["Seventy", "four", "per", "cent", "of", "C0015967#ent", "<e1>", "infected", "children", "were", "C0020625#ent", "<e2>", "(", "serum", "sodium", "than", "135", "mmol/l", ")", "compared", "with", "only", "8", "%", "of", "the", "afebrile", "controls", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [10, 11]}}
{"token": ["Spinal", "muscular", "atrophy", "C0026847#ent", "<e1>", ")", "is", "a", "common", "C4024896#ent", "<e2>", "results", "from", "reduced", "levels", "of", ",", "or", "mutations", "in", ",", "the", "Survival", "of", "Motor", "Neurons", "SMN", ")", "protein", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4024896", "name": "C4024896#ent", "pos": [9, 10]}}
{"token": ["Spinal", "muscular", "atrophy", "C0026847#ent", "<e1>", ")", "is", "a", "C4024896#ent", "<e2>", "by", "low", "levels", "of", "the", "survival", "motor", "neuron", "SMN", ")", "protein", "and", "is", "linked", "to", "mutations", "or", "loss", "of", "SMN1", "and", "retention", "of", "SMN2", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4024896", "name": "C4024896#ent", "pos": [8, 9]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "C0207890#ent", "<e1>", "is", "associated", "with", "reductions", "in", "TPR", "and", "sympathetic", "nerve", "activity", "C1420267#ent", "<e2>", ")", "."], "h": {"id": "C0207890", "name": "C0207890#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420267", "name": "C1420267#ent", "pos": [17, 18]}}
{"token": ["A", "63-year-old", "woman", "developed", "simultaneous", "occurrence", "of", "acute", "febrile", "neutrophilic", "dermatosis", "C0040149#ent", "<e1>", "thus", "suggesting", "that", "both", "C0012634#ent", "<e2>", "had", "a", "possible", "identical", "viral", "etiology"], "h": {"id": "C0040149", "name": "C0040149#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [17, 18]}}
{"token": ["In", "order", "to", "evaluate", "the", "effect", "of", "liver", "and", "C0035078#ent", "<e1>", "the", "metabolism", "of", "C0751039#ent", "<e2>", ",", "we", "studied", "twelve", "patients", "who", "had", "undergone", "liver", "transplantation"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [14, 15]}}
{"token": ["However", ",", "this", "reversible", ",", "probably", "drug-induced", "case", "of", "C2936664#ent", "<e1>", "highlights", "the", "need", "for", "immunoglobulin", "measurements", "immunodeficiency", "is", "suspected", "in", "C0024131#ent", "<e2>", "patients", "."], "h": {"id": "C2936664", "name": "C2936664#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024131", "name": "C0024131#ent", "pos": [21, 22]}}
{"token": ["To", "construct", "a", "lentiviral", "vector", "human", "C0376515#ent", "<e1>", "investigate", "its", "expression", "in", "human", "ovarian", "granulosa", "cells", "C4283933#ent", "<e2>", ")", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4283933", "name": "C4283933#ent", "pos": [16, 17]}}
{"token": ["In", "this", "preliminary", "study", ",", "we", "report", "the", "effect", "of", "C0003448#ent", "<e1>", "ATT", ")", "on", "cardiopulmonary", "responses", "exercise", "in", "patients", "with", "C0041321#ent", "<e2>", "MTB", ")", "."], "h": {"id": "C0003448", "name": "C0003448#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041321", "name": "C0041321#ent", "pos": [21, 22]}}
{"token": ["Levamisole", "causes", "vasopressor", "and", "panting", "effects", "which", "are", "blocked", "by", "C3536867#ent", "<e1>", "hexamethonium", "and", "mecamylamine", "but", "are", "not", "blocked", "by", "C0004259#ent", "<e2>", "."], "h": {"id": "C3536867", "name": "C3536867#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [20, 21]}}
{"token": ["Activation", "of", "C0033634#ent", "<e1>", "the", "phorbol", "ester", "12-O-tetradecanoyl-phorbol", "13-acetate", "decreased", "C1706649#ent", "<e2>", "mRNA", "by", "about", "40", "%", "in", "4", "h.", "Elevation", "of", "[Ca2+]i", "with", "ionomycin", "decreased", "C1706649#ent", "<e2>", "mRNA", "by", "about", "25", "%", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706649", "name": "C1706649#ent", "pos": [10, 11]}}
{"token": ["The", "results", "were", "compared", "with", "those", "for", "known", "surface-active", ",", "C0007904#ent", "<e1>", "CTAB", ")", "and", "C0007906#ent", "<e2>", "CPB", ")", "."], "h": {"id": "C0007904", "name": "C0007904#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007906", "name": "C0007906#ent", "pos": [15, 16]}}
{"token": ["Norepinephrine", "and", "C0031469#ent", "<e1>", ",", "but", "not", "isoproterenol", ",", "also", "stimulated", "C0235480#ent", "<e2>", "production", "in", "submandibular", "gland", "cells"], "h": {"id": "C0031469", "name": "C0031469#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [11, 12]}}
{"token": ["C0086376#ent", "<e1>", "and", "mRNA", "corresponding", "to", "C1705952#ent", "<e2>", "and", "its", "receptors", "were", "also", "identified", "in", "adult", "human", "testes", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705952", "name": "C1705952#ent", "pos": [6, 7]}}
{"token": ["Using", "these", "criteria", "provides", "good", "differentiation", "of", "C0006982#ent", "<e1>", "from", "other", "tauopathies", ",", "except", "frontotemporal", "dementia", "C0030567#ent", "<e2>", "linked", "to", "chromosome", "17", "where", "additional", "clinical", "or", "molecular", "genetic", "information", "required", "to", "make", "an", "accurate", "diagnosis", "."], "h": {"id": "C0006982", "name": "C0006982#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [16, 17]}}
{"token": ["Progressive", "supranuclear", "palsy", "PSP", ")", "and", "corticobasal", "degeneration", "C0006982#ent", "<e1>", ")", "are", "neurodegenerative", "disorders", "may", "be", "accompanied", "by", "dementia", "and", "C0030567#ent", "<e2>", "as", "clinical", "symptoms"], "h": {"id": "C0006982", "name": "C0006982#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [20, 21]}}
{"token": ["Congenital", "muscular", "dystrophy", "CMD", ")", "is", "a", "newly", "established", "group", "of", "progressive", "C0026850#ent", "<e1>", "comprising", "a", "number", "of", "new", "entities", ",", "including", "C0410174#ent", "<e2>", "FCMD", ")", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0410174", "name": "C0410174#ent", "pos": [22, 23]}}
{"token": ["Familial", "occurrence", "of", "cerebral", "malformations", "C0026850#ent", "<e1>", "described", "by", "C0410174#ent", "<e2>", "as", "congenital", "cerebromuscular", "dystrophy"], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0410174", "name": "C0410174#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "meloxicam", "7.5", "mg", "once", "daily", "is", "a", "promising", "treatment", "in", "C0038013#ent", "<e1>", "with", "efficacy", "comparable", "to", "C0027396#ent", "<e2>", "750", "mg", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [19, 20]}}
{"token": ["This", "C1848862#ent", "<e1>", "is", "usually", "associated", "with", "hypocalcemia", "resulting", "from", "C0020626#ent", "<e2>", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020626", "name": "C0020626#ent", "pos": [10, 11]}}
{"token": ["Antiserum", "to", "mouse", "C1332807#ent", "<e1>", "cross-reacted", "with", "four", "C0086376#ent", "<e2>", "of", "molecular", "weights", "to", "42,000", "in", "rat", "placental", "culture", "medium", "of", "which", "two", "were", "absent", "in", "the", "kidney", "."], "h": {"id": "C1332807", "name": "C1332807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["We", "measured", "calcium", "(", "Ca", ")", ",", "dry", "weight", "DW", ")", ",", "and", "hydroxyproline", "(", "C0733682#ent", "<e1>", ")", "of", "the", "distal", "femur", "percent", "of", "osteoblast", "(", "C2986870#ent", "<e2>", "."], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2986870", "name": "C2986870#ent", "pos": [26, 27]}}
{"token": ["To", "evaluate", "the", "role", "of", "glycogen", "depletion", "we", "accelerated", "C0002245#ent", "<e1>", "utilization", "by", "C3536880#ent", "<e2>", "administration", "."], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536880", "name": "C3536880#ent", "pos": [13, 14]}}
{"token": ["The", "case", "of", "a", "mentally", "retarded", "girl", "with", "a", "number", "of", "dysmorphic", "features", "C0034734#ent", "<e1>", "phenomenon", ",", "hypotonia", "and", "C0014553#ent", "<e2>", "presented", "."], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [19, 20]}}
{"token": ["This", "study", "examines", "the", "acute", "hemodynamic", "response", "to", "intravenous", "and", "C0600487#ent", "<e1>", "12", "patients", "with", "moderate", "to", "moderately", "severe", "C0018801#ent", "<e2>"], "h": {"id": "C0600487", "name": "C0600487#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["The", "use", "of", "phosphodiesterase", "inhibitors", "as", "C0600487#ent", "<e1>", "in", "the", "treatment", "of", "severe", "C0018801#ent", "<e2>", "frequently", "restricted", "because", "they", "cause", "vasodilation", "and", "hypotension", "."], "h": {"id": "C0600487", "name": "C0600487#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [13, 14]}}
{"token": ["This", "report", "studies", "the", "interaction", "of", "stereoisomers", "of", "C0018549#ent", "<e1>", "on", "the", "wild", "type", "on", "a", "variety", "of", "C0678941#ent", "<e2>", "Caenorhabditis", "elegans"], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0678941", "name": "C0678941#ent", "pos": [18, 19]}}
{"token": ["Other", "experiments", "were", "performed", "with", "rat", "C0669372#ent", "<e1>", "suspensions", ",", "including", "tests", "with", "various", "concentrations", "of", "C0009003#ent", "<e2>", "to", "incubates", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009003", "name": "C0009003#ent", "pos": [16, 17]}}
{"token": ["Using", "rat", "liver", "microsomal", "and", "isolated", "rat", "C0669372#ent", "<e1>", "incubation", "conditions", "that", "were", "effective", "in", "producing", "a", "CoA", "conjugate", "C0009003#ent", "<e2>", "no", "corresponding", "CoA", "derivative", "be", "found", "for", "either", "PFDA", "or", "PFOA", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009003", "name": "C0009003#ent", "pos": [19, 20]}}
{"token": ["Biopsy", "or", "necropsy", "specimens", "lung", "from", "28", "patients", "with", "congenital", "heart", "disease", "C0013080#ent", "<e1>", "studied", "to", "establish", "the", "cause", "of", "the", "postoperative", "C1145670#ent", "<e2>", "seen", "in", "such", "cases", "."], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [22, 23]}}
{"token": ["This", "report", "documents", "a", "case", "of", "C0036323#ent", "<e1>", "a", "South-East", "Asian", "refugee", "boy", "presented", "with", "C0231218#ent", "<e2>", ",", "abdominal", "distension", "and", "was", "found", "to", "have", "massive", "splenomegaly", "and", "esophageal", "varices"], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [15, 16]}}
{"token": ["The", "first", "IL-8", "peak", "was", "not", "altered", "with", "anti-TNFalpha", "mAb", "or", "IL-1", "C0003873#ent", "<e1>", ",", "whereas", "the", "second", "IL-8", "peak", "was", "reduced", "with", "C0245109#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0245109", "name": "C0245109#ent", "pos": [23, 24]}}
{"token": ["Modulation", "of", "the", "C1705677#ent", "<e1>", "level", "by", "C0011816#ent", "<e2>", ",", "1,25-(OH)2D3", ",", "and", "IGF-I", "suggests", "important", "roles", "for", "these", "binding", "proteins", "altering", "IGF-I", "action", "in", "rat", "osteoblast-like", "cell", "cultures", "."], "h": {"id": "C1705677", "name": "C1705677#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [7, 8]}}
{"token": ["We", "also", "identified", "C0086376#ent", "<e1>", "related", "to", "carbohydrate", "metabolism", "enolase", ",", "6-phosphogluconate", "dehydrogenase", "indole-3-glycerol", "phosphate", "synthase", "and", "C0016799#ent", "<e2>", ")", ",", "DNA", "translation", "probable", "elongation", "factor", "Tsf", ")", ",", "heat", "shock", "proteins", "and", "energy", "production", "ATP", "synthase", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016799", "name": "C0016799#ent", "pos": [17, 18]}}
{"token": ["The", "observation", "that", "Plasmodium", "falciparum", "C0056650#ent", "<e1>", "insensitive", "respiration", "that", "can", "be", "inhibited", "by", "C0073980#ent", "<e2>", "SHAM", ")", "and", "propyl", "gallate", "consistent", "with", "presence", "of", "an", "alternative", "oxidase", "AOX", ")", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0073980", "name": "C0073980#ent", "pos": [14, 15]}}
{"token": ["Inhibition", "by", "C0056650#ent", "<e1>", "and", "neocuproin", ",", "but", "not", "by", "C0073980#ent", "<e2>", "strongly", "suggests", "that", "copper", "is", "the", "metal", "involved", "in", "enzymatic", "urate", "oxidation", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0073980", "name": "C0073980#ent", "pos": [10, 11]}}
{"token": ["Myocardial", "expression", "C3813609#ent", "<e1>", "was", "examined", "using", "a", "monoclonal", "antibody", "72-", "to", "73-kDa", "C3890018#ent", "<e2>", "in", "additional", "rabbits", "."], "h": {"id": "C3813609", "name": "C3813609#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [13, 14]}}
{"token": ["C0055779#ent", "<e1>", "may", "therefore", "prove", "a", "useful", "clinical", "alternative", "to", "conventional", "C0728960#ent", "<e2>", "its", "lack", "of", "respiratory", "depressant", "properties", "and", "addiction", "potential", "in", "monkeys", "can", "be", "substantiated", "in", "humans", "."], "h": {"id": "C0055779", "name": "C0055779#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [11, 12]}}
{"token": ["It", "was", "inactivated", "by", "treatment", "with", "10", "mM", "dithiothreitol", ",", "5", "M", "urea", ",", "pronase", "or", "C0017976#ent", "<e1>", "but", "was", "stable", "on", "treatment", "with", "DNAase", ",", "C0011522#ent", "<e2>", "or", "neuraminidase", "."], "h": {"id": "C0017976", "name": "C0017976#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [26, 27]}}
{"token": ["Treatment", "of", "the", "human", "enzymes", "with", "specific", "C0017976#ent", "<e1>", "reveals", "that", "many", "of", "the", "human", "C0011522#ent", "<e2>", "are", "glycoproteins", "containing", "negatively", "charged", "moieties", "and", "may", "be", "derived", "from", "modification", "of", "parent", "activities"], "h": {"id": "C0017976", "name": "C0017976#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [15, 16]}}
{"token": ["C0001768#ent", "<e1>", "was", "the", "first", "example", "of", "an", "C0021051#ent", "<e2>", "IDS", ")", "."], "h": {"id": "C0001768", "name": "C0001768#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [8, 9]}}
{"token": ["Mouse", "erythrocyte", "rosette-forming", "cells", "and", "lymphocytes", "with", "surface", "immunoglobulins", "regularly", "absent", "in", "patients", "with", "C0001768#ent", "<e1>", "immunodeficiency", "and", "thymoma", "syndrome", "and", "severe", "combined", "C0021051#ent", "<e2>"], "h": {"id": "C0001768", "name": "C0001768#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [23, 24]}}
{"token": ["We", "have", "initiated", "a", "study", "of", "the", "human", "C0812214#ent", "<e1>", "of", "its", "potential", "importance", "as", "a", "human", "C1417123#ent", "<e2>", "."], "h": {"id": "C0812214", "name": "C0812214#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [17, 18]}}
{"token": ["In", "apical", "dendrites", "the", "C1271398#ent", "<e1>", "was", "significantly", "higher", "in", "amplitude", "and", "shorter", "in", "C2926735#ent", "<e2>", "compared", "with", "the", "somatic", "C1271398#ent", "<e1>", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1271398", "name": "C1271398#ent", "pos": [4, 5]}}
{"token": ["A", "recently", "discovered", "family", "of", "C0033640#ent", "<e1>", "responsible", "for", "an", "autosomal-dominant", "disease", "known", "as", "C0220666#ent", "<e2>", "pseudohypoaldosteronism", "type", "II", "PHA-II", ")", "that", "features", "hyperkalemia", "and", "hyperchloremic", "metabolic", "acidosis", "accompanied", "by", "hypertension", "and", "hypercalciuria", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0220666", "name": "C0220666#ent", "pos": [14, 15]}}
{"token": ["We", "have", "previously", "reported", "that", "nickel", "(Ni)-silenced", "expression", "of", "the", "C1412251#ent", "<e1>", "yeast", "(", "Saccharomyces", "cerevisiae", "and", "C0282641#ent", "<e2>", "G12", "Chinese", "hamster", "cells"], "h": {"id": "C1412251", "name": "C1412251#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282641", "name": "C0282641#ent", "pos": [17, 18]}}
{"token": ["C0370067#ent", "<e1>", "is", "indicated", "for", "treatment", "of", "serious", "infections", "including", "C0036690#ent", "<e2>", "."], "h": {"id": "C0370067", "name": "C0370067#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [10, 11]}}
{"token": ["The", "degradation", "of", "tryptophan", "by", "C1416433#ent", "<e1>", "a", "number", "of", "immunomodulatory", "metabolites", "including", "C0047442#ent", "<e2>", "3-hydroxykynurenic", "acid", "and", "quinolinic", "acid"], "h": {"id": "C1416433", "name": "C1416433#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0047442", "name": "C0047442#ent", "pos": [13, 14]}}
{"token": ["The", "inhibition", "of", "one-", "and", "two-chain", "forms", "of", "C0032143#ent", "<e1>", "a", "series", "of", "peptide", "derivatives", "of", "C0052330#ent", "<e2>", "studied", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0052330", "name": "C0052330#ent", "pos": [16, 17]}}
{"token": ["Like", "the", "unidentified", "endogenous", "partner(s", ")", ",", "both", "C1334501#ent", "<e1>", "and", "pKnox1", "failed", "to", "dimerize", "significantly", "with", "C1867800#ent", "<e2>", "."], "h": {"id": "C1334501", "name": "C1334501#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1867800", "name": "C1867800#ent", "pos": [17, 18]}}
{"token": ["SP", ",", "fluoride", "and", "guanine", "nucleotide", "effects", "on", "hydrolysis", "of", "C0259479#ent", "<e1>", "(", "PPI", ")", "were", "unaffected", "by", "pretreatment", "of", "anterior", "pituitary", "cells", "C0008354#ent", "<e2>", "or", "pertussis", "toxin", "12h", "."], "h": {"id": "C0259479", "name": "C0259479#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008354", "name": "C0008354#ent", "pos": [23, 24]}}
{"token": ["Microarray", "profiling", "21", "miRNAs", "clustered", "on", "chromosome", "12", "including", "C1826025#ent", "<e1>", "and", "miR-127", ",", "that", "were", "co-upregulated", "in", "small", "heterodimer", "partner", "C1334896#ent", "<e2>", ",", "NR0B2", ")", "C1334896#ent", "<e2>", "knockouts", "(", "SHP(-/-", ")", ")", "liver", "."], "h": {"id": "C1826025", "name": "C1826025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334896", "name": "C1334896#ent", "pos": [21, 22]}}
{"token": ["Estrogen", "related", "receptor", "ERRgamma", ",", "NR3B3", ")", "robustly", "activated", "C1826025#ent", "<e1>", "and", "miR-127", "promoter", "reporters", "ERRE", ",", "which", "was", "transrepressed", "by", "C1334896#ent", "<e2>", "."], "h": {"id": "C1826025", "name": "C1826025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334896", "name": "C1334896#ent", "pos": [21, 22]}}
{"token": ["Microarray", "profiling", "21", "miRNAs", "clustered", "on", "chromosome", "12", "including", "C1826025#ent", "<e1>", "and", "miR-127", ",", "that", "were", "co-upregulated", "in", "C1334896#ent", "<e2>", "SHP", ",", "NR0B2", ")", "SHP", "knockouts", "(", "SHP(-/-", ")", ")", "liver", "."], "h": {"id": "C1826025", "name": "C1826025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334896", "name": "C1334896#ent", "pos": [18, 19]}}
{"token": ["Enterococcal", "superinfections", "in", "both", "groups", "(", "a", "bacteremic", "urinary", "tract", "infection", "a", "ceftazidime", "patient", "and", "C0029443#ent", "<e1>", "in", "a", "C0008809#ent", "<e2>", "patient", ")", "."], "h": {"id": "C0029443", "name": "C0029443#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [19, 20]}}
{"token": ["Exogenous", "human", "recombinant", "C1705819#ent", "<e1>", "abolished", "1,25", "(", "OH", ")", "2vitD3", "stimulated", "C0009325#ent", "<e2>", "degradation", "and", "inhibited", "background", "collagenolysis", "."], "h": {"id": "C1705819", "name": "C1705819#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "whether", "elevated", "serum", "C0534628#ent", "<e1>", "can", "be", "observed", "in", "patients", "with", "idiopathic", "pulmonary", "fibrosis", "C1800706#ent", "<e2>", ")", ",", "we", "measured", "serum", "levels", "of", "C0534628#ent", "<e1>", "in", "69", "patients", "with", "benign", "respiratory", "disease", "an", "ELISA", "kit"], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0534628", "name": "C0534628#ent", "pos": [5, 6]}}
{"token": ["Recent", "studies", "have", "demonstrated", "that", "activated", "microglia", "play", "an", "important", "role", "in", "dopamine", "(", "DA", ")", "neuronal", "degeneration", "C0030567#ent", "<e1>", "PD", ")", "by", "generating", "NADPH-oxidase", "(NADPHO)-derived", "C0038838#ent", "<e2>", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [26, 27]}}
{"token": ["COX-2", "also", "played", "a", "role", "in", "gonadotropin-induced", "apoptosis", ",", "as", "treatment", "with", "the", "COX-2-specific", "inhibitor", "C0215737#ent", "<e1>", "or", "COX-2", "small", "interfering", "RNA", "blocked", "C0342543#ent", "<e2>", "apoptotic", "activity"], "h": {"id": "C0215737", "name": "C0215737#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0342543", "name": "C0342543#ent", "pos": [23, 24]}}
{"token": ["Several", "cellular", "signalling", ",", "including", "C1417708#ent", "<e1>", "and", "the", "target", "of", "rapamycin", "(", "C0076836#ent", "<e2>", ")", "pathways", "appear", "to", "be", "regulated", "by", "Ppp4", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0076836", "name": "C0076836#ent", "pos": [13, 14]}}
{"token": ["This", "paper", "describes", "the", "development", "of", "a", "murine", "bank", "of", "monoclonal", "antibodies", "Bordetella", "pertussis", "toxin", "C1509509#ent", "<e1>", "FHA", ")", ",", "pili", ",", "lipopolysaccharide", "(", "C0175697#ent", "<e2>", ")", ",", "or", "outer", "membrane", "proteins", "OMPs", ")", "."], "h": {"id": "C1509509", "name": "C1509509#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [24, 25]}}
{"token": ["Monoclonal", "antibodies", "Bordetella", "pertussis", "C1509509#ent", "<e1>", "FHA", ")", "and", "lipopolysaccharide", "(", "C0175697#ent", "<e2>", ")", "were", "used", "in", "a", "colony", "blot", "enzyme-linked", "immunosorbent", "assay", "for", "rapid", "detection", "of", "B.", "pertussis"], "h": {"id": "C1509509", "name": "C1509509#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [11, 12]}}
{"token": ["Several", "different", "types", "of", "pain", "are", "found", "in", "patients", "with", "MS", ",", "including", "extremity", "pain", "C0040997#ent", "<e1>", "Lhermitte's", "sign", "painful", "tonic", "spasms", ",", "back", "pain", "and", "C0270697#ent", "<e2>", "."], "h": {"id": "C0040997", "name": "C0040997#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [26, 27]}}
{"token": ["Clinically", ",", "the", "most", "common", "symptom", "was", "C0040997#ent", "<e1>", "followed", "by", "C0270697#ent", "<e2>", "."], "h": {"id": "C0040997", "name": "C0040997#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [11, 12]}}
{"token": ["question", "of", "the", "C0264511#ent", "<e1>", "and", "the", "C1851100#ent", "<e2>", "(", "short", "form", ")", "."], "h": {"id": "C0264511", "name": "C0264511#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1851100", "name": "C1851100#ent", "pos": [7, 8]}}
{"token": ["Studies", "of", "aggrecan", "proteolysis", "in", "human", "joints", "have", "implicated", "both", "the", "C0247689#ent", "<e1>", "[", "ADAMTS", ",", "a", "C1313290#ent", "<e2>", "reprolysin-type", ")", "with", "thrombospondin", "type", "1", "motif", "and", "matrix", "metalloproteinase", "MMP", ")", "families", "."], "h": {"id": "C0247689", "name": "C0247689#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1313290", "name": "C1313290#ent", "pos": [17, 18]}}
{"token": ["A", "case", "of", "C0038450#ent", "<e1>", "due", "to", "C0038013#ent", "<e2>", "the", "cricoarytenoid", "joints", "presented", ",", "with", "special", "emphasis", "on", "a", "new", "line", "of", "treatment", "by", "local", "intra-articular", "steroid", "injection", "."], "h": {"id": "C0038450", "name": "C0038450#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}}
{"token": ["Antibodies", "against", "BIG1", "or", "C1417613#ent", "<e1>", "coprecipitated", "both", "C0086376#ent", "<e2>", "from", "nuclei", ",", "which", "was", "abolished", "by", "the", "incubation", "of", "nuclei", "with", "RNase", "A", "DNase", ",", "indicating", "that", "the", "interaction", "depended", "on", "nucleic", "acids"], "h": {"id": "C1417613", "name": "C1417613#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["Low", "levels", "of", "circulating", "C1527149#ent", "<e1>", "have", "been", "correlated", "with", "a", "high", "risk", "C1956346#ent", "<e2>"], "h": {"id": "C1527149", "name": "C1527149#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [13, 14]}}
{"token": ["We", "determined", "the", "efficacy", "of", "K-111", "in", "C1334981#ent", "<e1>", "primates", "in", "increasing", "insulin-stimulated", "glucose", "uptake", "and", "improving", "C0524620#ent", "<e2>", "assessing", "the", "general", "health-related", "effects", "."], "h": {"id": "C1334981", "name": "C1334981#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [17, 18]}}
{"token": ["The", "Escherichia", "coli", "RNA", "degradosome", "a", "multi-enzyme", "complex", "contains", "the", "exoribonuclease", "polynucleotide", "phosphorylase", "C1427960#ent", "<e1>", ")", "and", "the", "endoribonuclease", "RNase", "E.", "C3540790#ent", "<e2>", "are", "important", "in", "RNA", "processing", "and", "messenger", "RNA", "degradation", "."], "h": {"id": "C1427960", "name": "C1427960#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [21, 22]}}
{"token": ["The", "Escherichia", "coli", "RNA", "degradosome", "a", "multi-enzyme", "complex", "contains", "the", "C1427960#ent", "<e1>", "PNPase", ")", "and", "the", "endoribonuclease", "RNase", "E.", "C3540790#ent", "<e2>", "are", "important", "in", "RNA", "processing", "and", "messenger", "RNA", "degradation", "."], "h": {"id": "C1427960", "name": "C1427960#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [19, 20]}}
{"token": ["We", "found", "that", "alpha2AR", "C2987634#ent", "<e1>", ",", "UK", "14,304", ",", "clonidine", "and", "C0125656#ent", "<e2>", "were", "potent", "inhibitors", "of", "anion", "secretion", "especially", "in", "the", "proximal", "colon", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0125656", "name": "C0125656#ent", "pos": [12, 13]}}
{"token": ["Sequence", "comparison", "between", "these", "C0599220#ent", "<e1>", ",", "the", "corresponding", "C0599220#ent", "<e1>", "of", "the", "bovine", "complex", "I", "the", "bacterial", "C0063085#ent", "<e1>", "confirms", "the", "binding", "sites", "of", "NAD(H", ")", ",", "FMN", "and", "three", "iron-sulfur", "clusters"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0063085", "name": "C0063085#ent", "pos": [18, 19]}}
{"token": ["Both", "C0599220#ent", "<e1>", "are", "related", "to", "the", "soluble", "C0063085#ent", "<e2>", "the", "bacterium", "Alcaligenes", "eutrophus"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0063085", "name": "C0063085#ent", "pos": [8, 9]}}
{"token": ["This", "mutation", "at", "codon", "200", "changes", "glutamic", "acid", "by", "C0017346#ent", "<e1>", "to", "lysine", "coded", "by", "C2986643#ent", "<e2>", "."], "h": {"id": "C0017346", "name": "C0017346#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986643", "name": "C2986643#ent", "pos": [15, 16]}}
{"token": ["After", "hypertonic", "saline", "Sosm", "increased", "to", "the", "same", "degree", "both", "in", "C2987024#ent", "<e1>", "and", "control", "subjects", "but", "C1706109#ent", "<e2>", "increased", "more", "in", "those", "with", "C2987024#ent", "<e1>", "."], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2987024", "name": "C2987024#ent", "pos": [11, 12]}}
{"token": ["Pain", ",", "C2936719#ent", "<e1>", "edema", ",", "increased", "skin", "temperature", "and", "C0041834#ent", "<e2>", "characteristic", "symptoms", "of", "acute", "complex", "pain", "syndrome", "(", "CRPS", ")", "."], "h": {"id": "C2936719", "name": "C2936719#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [10, 11]}}
{"token": ["Patients", "asymptomatic", "at", "presentation", "(", "n", "=", "31", ")", "had", "lower", "C0002484#ent", "<e1>", "bilirubin", ",", "and", "C3536873#ent", "<e2>", "IgG", ")", "values", "at", "baseline", "."], "h": {"id": "C0002484", "name": "C0002484#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3536873", "name": "C3536873#ent", "pos": [16, 17]}}
{"token": ["There", "is", "considerable", "molecular", "heterogeneity", "8", "partner", "C0017337#ent", "<e1>", "currently", "known", "for", "FGFR1", ",", "6", "for", "C1335201#ent", "<e2>", "and", "17", "for", "PDGFRB", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335201", "name": "C1335201#ent", "pos": [16, 17]}}
{"token": ["About", "half", "of", "all", "normal-tension", "glaucoma", "patients", "and", "about", "one", "third", "of", "all", "primary", "C0339573#ent", "<e1>", "patients", "have", "C0520680#ent", "<e2>"], "h": {"id": "C0339573", "name": "C0339573#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0520680", "name": "C0520680#ent", "pos": [18, 19]}}
{"token": ["C2917660#ent", "<e1>", "substitutions", "at", "positions", "P5", "C1539372#ent", "<e2>", ",", "and", "P2", "resulted", "in", "substrates", "which", "were", "processed", "by", "the", "49-kDa", "TEV", "proteinase", ",", "albeit", "generally", "at", "reduced", "rates", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539372", "name": "C1539372#ent", "pos": [6, 7]}}
{"token": ["Our", "objective", "was", "to", "study", "the", "direct", "action", "of", "the", "C1518041#ent", "<e1>", "SB-75", "and", "the", "agonist", "C0006456#ent", "<e2>", "on", "the", "proliferation", "of", "endometrial", "cancer", "cells"], "h": {"id": "C1518041", "name": "C1518041#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006456", "name": "C0006456#ent", "pos": [16, 17]}}
{"token": ["C1518041#ent", "<e1>", "such", "as", "leuprolide", ",", "C0006456#ent", "<e2>", ",", "triptrelin", "and", "goserelin", ",", "are", "available", "for", "premenopausal", "patients", ",", "and", "showed", "a", "37", "%", "response", "rate", "average", "."], "h": {"id": "C1518041", "name": "C1518041#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006456", "name": "C0006456#ent", "pos": [6, 7]}}
{"token": ["We", "present", "2", "patients", "with", "C0030567#ent", "<e1>", "showed", "persisting", "C0040822#ent", "<e2>", "was", "most", "marked", "during", "action", "rather", "than", "during", "rest", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0040822", "name": "C0040822#ent", "pos": [9, 10]}}
{"token": ["The", "administration", "of", "17", "C0014914#ent", "<e1>", "to", "ovariectomized", "rats", "stimulated", "in", "uterus", "the", "activity", "of", "C0072632#ent", "<e2>", "the", "rate-limiting", "enzyme", "in", "the", "polyamine", "interconversion", "pathway", "."], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072632", "name": "C0072632#ent", "pos": [15, 16]}}
{"token": ["The", "occurrence", "of", "a", "dopa-sensitive", "parkinsonian", "syndrome", "years", "after", "a", "neuropathy", "suggestive", "of", "C0270914#ent", "<e1>", "the", "possibility", "of", "a", "relationship", "between", "these", "two", "C0012634#ent", "<e2>", "."], "h": {"id": "C0270914", "name": "C0270914#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [23, 24]}}
{"token": ["We", "have", "investigated", "the", "possible", "effect", "of", "C1825346#ent", "<e1>", "on", "phagocytic", "activity", "peritoneal", "macrophages", "acute", "cold-restraint", "stress", "(", "C0010278#ent", "<e2>", ")", "exposed", "rats", "."], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [18, 19]}}
{"token": ["C0038792#ent", "<e1>", "is", "a", "non-steroidal", "antiinflammatory", "drug", "NSAID", ")", "known", "to", "inhibit", "C1565860#ent", "<e2>", "(", "COX", ")", "1", "and", "2", ",", "and", "at", "present", "of", "interest", "for", "cancer", "prevention"], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [12, 13]}}
{"token": ["C0207803#ent", "<e1>", "RDP", ")", "is", "an", "enzyme", "C3889446#ent", "<e2>", "in", "benign", "and", "malignant", "colorectal", "tumors"], "h": {"id": "C0207803", "name": "C0207803#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [7, 8]}}
{"token": ["These", "data", "suggest", "that", "the", "N-acetoxy", "metabolites", "of", "C0038760#ent", "<e1>", "could", "potentially", "play", "a", "role", "in", "mediating", "C3536763#ent", "<e2>", "idiosyncratic", "adverse", "drug", "reactions"], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [8, 9]}, "relation": "structural_class_of", "t": {"id": "C3536763", "name": "C3536763#ent", "pos": [17, 18]}}
{"token": ["Large", "amounts", "of", "C1416669#ent", "<e1>", "found", "to", "be", "released", "into", "the", "peritoneal", "exudates", "in", "C0030305#ent", "<e2>"], "h": {"id": "C1416669", "name": "C1416669#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [14, 15]}}
{"token": ["It", "is", "concluded", "that", "C1334539#ent", "<e1>", "manifestations", "of", "oxidative", "stress", "serve", "as", "useful", "bioindicators", "of", "C1414863#ent", "<e2>", "exposure", "and", "toxicity", "in", "wild", "aquatic", "birds", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [15, 16]}}
{"token": ["The", "ADULT", "syndrome", "C1863204#ent", "<e1>", ",", "OMIM", "103285", ")", "is", "a", "rare", "C0013575#ent", "<e2>", "associated", "with", "limb", "malformations", "caused", "by", "heterozygous", "mutations", "in", "p63", "."], "h": {"id": "C1863204", "name": "C1863204#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0013575", "name": "C0013575#ent", "pos": [12, 13]}}
{"token": ["The", "C1863204#ent", "<e1>", "Acro-Dermato-Ungual-Lacrimal-Tooth", ",", "OMIM", "103285", ")", "is", "a", "rare", "C0013575#ent", "<e2>", "associated", "with", "limb", "malformations", "caused", "by", "heterozygous", "mutations", "in", "p63", "."], "h": {"id": "C1863204", "name": "C1863204#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0013575", "name": "C0013575#ent", "pos": [11, 12]}}
{"token": ["Patients", "were", "divided", "into", "two", "groups", "(", "C0032285#ent", "<e1>", "n", "=", "14", "or", "C2350236#ent", "<e2>", "obliterans", "(", "BO", ")", ",", "n", "=", "6", ")", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2350236", "name": "C2350236#ent", "pos": [13, 14]}}
{"token": ["The", "application", "of", "ISH", "and", "IHC", "did", "not", "change", "significantly", "the", "routine", "histologic", "classification", "of", "C0032285#ent", "<e1>", "into", "CMV-IP", "and", "C2350236#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2350236", "name": "C2350236#ent", "pos": [20, 21]}}
{"token": ["The", "therapy", "consisted", "of", "nonsteroidal", "antiinflammatory", "NSAIDs", ")", "drugs", "in", "C3898105#ent", "<e1>", "subset", ",", "NSAIDs", "and", "Methotrexate", "(", "C0025677#ent", "<e2>", ")", "in", "polyarticular", ",", "NSAIDs", "and", "steroids", "in", "systemic", "onset"], "h": {"id": "C3898105", "name": "C3898105#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [18, 19]}}
{"token": ["The", "therapy", "consisted", "of", "nonsteroidal", "antiinflammatory", "NSAIDs", ")", "drugs", "in", "C3898105#ent", "<e1>", "subset", ",", "NSAIDs", "and", "C0025677#ent", "<e2>", "(", "MTX", ")", "in", "polyarticular", ",", "NSAIDs", "and", "steroids", "in", "systemic", "onset"], "h": {"id": "C3898105", "name": "C3898105#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [16, 17]}}
{"token": ["The", "antibody", ",", "which", "binds", "human", "C1415975#ent", "<e1>", ",", "contains", "two", "C0052546#ent", "<e2>", "sequences", "within", "its", "CDRs", ",", "but", "only", "one", "site", "was", "found", "to", "be", "labile", "to", "isomerization", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0052546", "name": "C0052546#ent", "pos": [11, 12]}}
{"token": ["Of", "the", "two", "splicing", "variants", "of", "C1423885#ent", "<e1>", "mRNA", ",", "the", "short", "and", "the", "long", "forms", "long-form", "C1423885#ent", "<e1>", "mRNA", "was", "found", "to", "be", "the", "major", "C0597298#ent", "<e1>", "."], "h": {"id": "C1423885", "name": "C1423885#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [26, 27]}}
{"token": ["To", "identify", "patients", "with", "coexisting", "HIV", "infection", "tuberculosis", "(", "C0077025#ent", "<e1>", ")", "and", "recent", "trends", "in", "prevalence", "and", "factors", "associated", "with", "C0009450#ent", "<e2>", "."], "h": {"id": "C0077025", "name": "C0077025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [21, 22]}}
{"token": ["To", "elucidate", "the", "mechanisms", "underlying", "the", "demethylating", "effects", "of", "C2984132#ent", "<e1>", ",", "we", "examined", "expression", "levels", "of", "DNA", "methyltransferases", "C0012873#ent", "<e2>", ")", ",", "1", ",", "3A", "and", "3B", "in", "CSE-treated", "cells", "."], "h": {"id": "C2984132", "name": "C2984132#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012873", "name": "C0012873#ent", "pos": [19, 20]}}
{"token": ["C0020261#ent", "<e1>", "not", "prevent", "the", "hyperuricemia", "or", "C0852949#ent", "<e2>", "despite", "controlling", "blood", "pressure"], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0852949", "name": "C0852949#ent", "pos": [7, 8]}}
{"token": ["The", "use", "of", "pentane-1,5-diol", "in", "C0013227#ent", "<e1>", "relatively", "new", "compared", "with", ",", "e.g.", ",", "C0033436#ent", "<e2>", "(", "propylene", "glycol", ",", "also", "an", "aliphatic", "diol", ",", "which", "has", "been", "used", "for", "many", "years", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033436", "name": "C0033436#ent", "pos": [14, 15]}}
{"token": ["Human", "C1367482#ent", "<e1>", ",", "a", "RNase", "evolutionarily", "more", "distant", "to", "C1419408#ent", "<e2>", "and", "hPR", ",", "did", "not", "display", "such", "activating", "effects", "."], "h": {"id": "C1367482", "name": "C1367482#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419408", "name": "C1419408#ent", "pos": [10, 11]}}
{"token": ["Various", "C0009326#ent", "<e1>", "reported", "in", "patients", "infected", "by", "the", "HIV", "(", "C3854222#ent", "<e2>", ";", "in", "most", "cases", ",", "they", "are", "related", "to", "Reiter's", "syndrome", "reactive", "arthritis", "opportunistic", "germs", "arthritis", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [11, 12]}}
{"token": ["A", "routine", "search", "of", "the", "public", "databases", "sequences", "homologous", "to", "C1420088#ent", "<e1>", "identified", "3", "expressed", "sequence", "tags", "C1420459#ent", "<e2>", ")", "that", "show", "strong", "similarities", "to", "the", "mammalian", "protein"], "h": {"id": "C1420088", "name": "C1420088#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420459", "name": "C1420459#ent", "pos": [17, 18]}}
{"token": ["Its", "favorable", "risk/benefit", "ratio", ",", "a", "broad", "clinical", "experience", "in", "kidney", "transplantation", "and", "its", "recent", "extension", "to", "other", "C0035435#ent", "<e1>", "that", "this", "new", "C3536926#ent", "<e2>", "significant", "therapeutic", "potential", "for", "suppression", "of", "synovial", "inflammation"], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [18, 19]}, "relation": "may_be_prevented_by", "t": {"id": "C3536926", "name": "C3536926#ent", "pos": [23, 24]}}
{"token": ["Established", "chicken", "T", "cell", "RP13", ")", "and", "macrophage", "(", "HD11", ")", "cell", "lines", "expressed", "substantially", "higher", "levels", "of", "C1416387#ent", "<e1>", "compared", "with", "a", "B", "cell", "line", "C1419617#ent", "<e2>", ")", "."], "h": {"id": "C1416387", "name": "C1416387#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1419617", "name": "C1419617#ent", "pos": [26, 27]}}
{"token": ["Compound", "A", "shown", "to", "be", "a", "more", "potent", "and", "efficacious", "C0242339#ent", "<e1>", "atherogenic", "rat", "db/db", "mouse", "models", "compared", "with", "C0033228#ent", "<e2>", "."], "h": {"id": "C0242339", "name": "C0242339#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [19, 20]}}
{"token": ["The", "triad", "of", "endocarditis", ",", "C0025289#ent", "<e1>", "and", "pneumonia", "caused", "by", "C0032269#ent", "<e2>", "IPD", ")", "is", "most", "commonly", "associated", "with", "excess", "alcohol", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0032269", "name": "C0032269#ent", "pos": [11, 12]}}
{"token": ["This", "report", "describes", "two", "cases", "of", "Osler's", "triad", "pneumonia", ",", "C0025289#ent", "<e1>", ",", "and", "endocarditis", ",", "as", "a", "result", "of", "C0032269#ent", "<e2>", "also", "called", "Austrian's", "syndrome"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0032269", "name": "C0032269#ent", "pos": [20, 21]}}
{"token": ["Pneumonia", "and", "C0025289#ent", "<e1>", "are", "the", "2", "most", "frequent", "manifestations", "of", "C0032269#ent", "<e2>"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0032269", "name": "C0032269#ent", "pos": [11, 12]}}
{"token": ["On", "the", "basis", "of", "our", "genomic", "analyses", "we", "can", "localize", "the", "C0079429#ent", "<e1>", "for", "S100L", "within", "5", "kb", "upstream", "of", "C1706266#ent", "<e2>", ",", "thus", "extending", "the", "S100", "gene", "cluster", "one", "C0079429#ent", "<e1>", "."], "h": {"id": "C1706266", "name": "C1706266#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", "to", "others", ",", "we", "could", "not", "obtain", "evidence", "for", "an", "increase", "in", "the", "degree", "of", "prolyl", "hydroxylation", "C0009325#ent", "<e1>", "of", "the", "C0013264#ent", "<e2>", "muscle", "cells"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0013264", "name": "C0013264#ent", "pos": [23, 24]}}
{"token": ["These", "results", "strongly", "suggest", "that", "the", "increased", "amount", "of", "C0009325#ent", "<e1>", "present", "in", "C0013264#ent", "<e2>", "related", "to", "the", "primary", "defect", "the", "disease", "and", "is", "not", "due", "to", "a", "secondary", "replacement", "fibrosis", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013264", "name": "C0013264#ent", "pos": [13, 14]}}
{"token": ["However", ",", "binding", "of", "C0001477#ent", "<e1>", "both", "EF-1", "and", "EF-3", "is", "necessary", "for", "C1418406#ent", "<e2>", "interaction", "with", "Alix/AIP1", "as", "demonstrated", "using", "surface", "plasmon", "resonance", "spectroscopy"], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418406", "name": "C1418406#ent", "pos": [13, 14]}}
{"token": ["Heparin", "bound", "to", "C0165519#ent", "<e1>", "type", "IX", "collagen", "fibronectin", ",", "laminin", ",", "and", "C1336937#ent", "<e2>", ";", "and", "chondroitin", "sulfate", "E", "to", "type", "II", "type", "V", "and", "type", "VII", "collagen"], "h": {"id": "C0165519", "name": "C0165519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336937", "name": "C1336937#ent", "pos": [13, 14]}}
{"token": ["This", "novel", "non-receptor-mediated", "pathway", "activating", "C1705065#ent", "<e1>", "might", "contribute", "to", "neuronal", "death", "C0020179#ent", "<e2>"], "h": {"id": "C1705065", "name": "C1705065#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020179", "name": "C0020179#ent", "pos": [12, 13]}}
{"token": ["SP600125", "was", "selective", "for", "JNK", "in", "vitro", "in", "vivo", "other", "C0031727#ent", "<e1>", "tested", "including", "ERK", ",", "p38", ",", "C1447440#ent", "<e2>", "CDK1", ")", ",", "and", "CDK2", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1447440", "name": "C1447440#ent", "pos": [18, 19]}}
{"token": ["The", "listed", "immunoserological", "parameters", "make", "it", "largely", "possible", "to", "differentiate", "classical", "PBC", ",", "mixed", "forms", "overlap", "of", "PBC", "and", "C0520463#ent", "<e1>", ",", "autoimmune", "CAH", "nonpurulent", "cholangitis", "of", "C0031052#ent", "<e2>"], "h": {"id": "C0520463", "name": "C0520463#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0031052", "name": "C0031052#ent", "pos": [27, 28]}}
{"token": ["She", "developed", "C0549423#ent", "<e1>", "miliary", "spread", "of", "C0041296#ent", "<e2>", "which", "led", "to", "death", "."], "h": {"id": "C0549423", "name": "C0549423#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [7, 8]}}
{"token": ["We", "mapped", "HCV-DCM", "susceptibility", "to", "a", "non-HLA", "gene", "locus", "spanning", "from", "C1417711#ent", "<e1>", "to", "MICA", "gene", "loci", "the", "C0017349#ent", "<e2>", "I", "boundary", "region", "."], "h": {"id": "C1417711", "name": "C1417711#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017349", "name": "C0017349#ent", "pos": [18, 19]}}
{"token": ["This", "phenotypically", "altered", "C1539322#ent", "<e1>", "generates", "a", "factor", ",", "termed", "smooth", "muscle", "extracellular", "matrix", "factor", "C3273431#ent", "<e2>", ")", ",", "and", "possibly", "other", "factors", "."], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273431", "name": "C3273431#ent", "pos": [15, 16]}}
{"token": ["The", "relative", "influences", "of", "the", "putative", "thyroid", "stimulator", ",", "pregnancy", "state", "C0015190#ent", "<e1>", "were", "assessed", "in", "52", "patients", "with", "gestational", "trophoblastic", "neoplasia", "C0731141#ent", "<e2>", ")", "."], "h": {"id": "C0015190", "name": "C0015190#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0731141", "name": "C0731141#ent", "pos": [22, 23]}}
{"token": ["Absolute", "testis", "weights", "were", "increased", "at", "PND1", "by", "myclobutanil", ",", "at", "PND22", "by", "myclobutanil", "and", "C0076996#ent", "<e1>", ",", "and", "at", "PND50", "by", "C0025942#ent", "<e2>", "and", "C0076996#ent", "<e1>", "treatment", "."], "h": {"id": "C0076996", "name": "C0076996#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [22, 23]}}
{"token": ["To", "evoke", "different", "levels", "of", "smooth", "muscle", "contraction", "ET-1", "or", "C0235480#ent", "<e1>", ",", "mediators", "involved", "in", "C0034087#ent", "<e2>", "were", "used", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034087", "name": "C0034087#ent", "pos": [16, 17]}}
{"token": ["Autosomal", "dominant", "C0687720#ent", "<e1>", "ADNDI", ")", "is", "a", "familial", "form", "C0011848#ent", "<e2>", "to", "progressive", "vasopressin", "deficiency", "onset", "typically", "at", "1", "-", "6", "yr", "of", "age", "."], "h": {"id": "C0687720", "name": "C0687720#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [10, 11]}}
{"token": ["In", "11", "patients", "with", "C0687720#ent", "<e1>", "effectiveness", "of", "the", "vasopressin", "analogue", "1-desamino-8-D-arginine", "vasopressin", "DDAVP", ")", "for", "controlling", "C0011848#ent", "<e2>", "been", "compared", "with", "that", "of", "lysine", "vasopressin"], "h": {"id": "C0687720", "name": "C0687720#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [17, 18]}}
{"token": ["The", "biological", "functions", "mast", "cells", "regulated", "by", "several", "protein", "kinases", "including", "the", "tyrosine", "kinases", "Fyn", "C0812307#ent", "<e1>", ",", "Syk", ",", "and", "C0059239#ent", "<e2>", "and", "the", "serine/threonine", "kinases", "Akt", "and", "PKC", "alpha/beta", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [21, 22]}}
{"token": ["C0243902#ent", "<e1>", "activates", "transcription", "from", "the", "C1456377#ent", "<e2>", "in", "vitro", "initiation", "site", "L325", ",", "via", "its", "binding", "to", "the", "template", "DNA"], "h": {"id": "C0243902", "name": "C0243902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [6, 7]}}
{"token": ["Finally", ",", "these", "results", "suggest", "the", "C0772110#ent", "<e1>", "as", "lactate", "facilitate", "the", "dissociation", "of", "MnIII", "from", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C0772110", "name": "C0772110#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}}
{"token": ["This", "case", "illustrates", "that", "C0020676#ent", "<e1>", "present", "only", "with", "C0235660#ent", "<e2>", "and", "pituitary", "mass", "and", "should", "therefore", "be", "considered", "in", "the", "differential", "diagnosis", "hyperprolactinaemia", "and", "pituitary", "enlargement"], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0235660", "name": "C0235660#ent", "pos": [9, 10]}}
{"token": ["We", "examined", "the", "effect", "of", "C1418450#ent", "<e1>", "on", "kinase", "activity", "C1442788#ent", "<e2>", "and", "found", "that", "C1418450#ent", "<e1>", "downregulated", "FGF-2-promoted", "C1442788#ent", "<e2>", "activity", "by", "tyrosine", "phosphorylation", "the", "C-terminus", "in", "a", "Fes-dependent", "manner", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418450", "name": "C1418450#ent", "pos": [5, 6]}}
{"token": ["The", "CD28", "cytoplasmic", "tail", "several", "potential", "phosphorylation", "sites", "for", "the", "C0072402#ent", "<e1>", "PKC", ")", "and/or", "proline-directed", "serine/threonine", "kinases", "such", "as", "C0600388#ent", "<e2>"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [20, 21]}}
{"token": ["Respective", "loci", "contribute", "to", "the", "activation/suppression", "of", "apoptosis", ",", "are", "involved", "in", "signal", "transduction", "cell", "cycle", "regulators", "they", "belong", "to", "the", "C1336836#ent", "<e1>", "caspase", "related", "genes", "or", "the", "C4042483#ent", "<e2>"], "h": {"id": "C1336836", "name": "C1336836#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C4042483", "name": "C4042483#ent", "pos": [28, 29]}}
{"token": ["sulphamoxole", ",", "C0037134#ent", "<e1>", "or", "sulfametopyrazine", ")", ",", "but", "the", "C0038760#ent", "<e2>", "a", "contributor", "to", "clinical", "efficacy", "increasingly", "questioned", "."], "h": {"id": "C0037134", "name": "C0037134#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [10, 11]}}
{"token": ["The", "contrast", "between", "the", "two", "quantitative", "trait", "loci", "C0597336#ent", "<e1>", ")", "alleles", "associated", "with", "polymorphism", "in", "the", "C0087140#ent", "<e2>", "gene", "explained", "up", "to", "5.13", "%", "of", "the", "total", "variance"], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [17, 18]}}
{"token": ["Some", "quaternary", "ammonium", "derivatives", "of", "C0013901#ent", "<e1>", "are", "active", "C0013227#ent", "<e2>", "both", "experimental", "and", "human", "tumors", "."], "h": {"id": "C0013901", "name": "C0013901#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}}
{"token": ["To", "evaluate", "autonomic", "activity", "dexmedetomidine", "or", "C0015846#ent", "<e1>", "infusion", "and", "C0063252#ent", "<e2>", "laparoscopic", "gastric", "banding"], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0063252", "name": "C0063252#ent", "pos": [10, 11]}}
{"token": ["C0015846#ent", "<e1>", "was", "discontinued", "and", "C0063252#ent", "<e2>", ",", "6", "%", "endtidal", ",", "was", "administered", "and", "the", "EPS", "repeated", "."], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0063252", "name": "C0063252#ent", "pos": [5, 6]}}
{"token": ["Enhanced", "activity", "of", "protein", "kinase", "A", "C0010531#ent", "<e1>", ")", "isoforms", "Tpk1p", "and", "Tpk2p", "or", "exogenous", "overexpression", "of", "C1539560#ent", "<e2>", "led", "to", "Efg1p-dependent", "down-regulation", "of", "the", "endogenous", "C1539560#ent", "<e2>", "promoter", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539560", "name": "C1539560#ent", "pos": [17, 18]}}
{"token": ["Immunoblot", "analysis", "the", "presence", "of", "the", "enzymes", "also", "in", "extrahepatic", "tissues", "especially", "in", "the", "brain", "and", "testis", "(", "C1825831#ent", "<e1>", ")", ",", "and", "in", "the", "heart", "and", "kidney", "(", "C1422394#ent", "<e2>", ")", "."], "h": {"id": "C1825831", "name": "C1825831#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1422394", "name": "C1422394#ent", "pos": [29, 30]}}
{"token": ["In", "vitro", "dephosphorylation", "of", "HeLa", "cellular", "HDH", "II/Ku", "caused", "a", "significant", "decrease", "in", "the", "C0610268#ent", "<e1>", "activity", "of", "this", "C0027203#ent", "<e2>", "."], "h": {"id": "C0610268", "name": "C0610268#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [19, 20]}}
{"token": ["The", "C0027203#ent", "<e1>", "possesses", "DNA-dependent", "ATPase", "DNA-dependent", "GTPase", "C0610268#ent", "<e2>", "and", "DNA", "primase", "activities", "that", "are", "essentially", "identical", "to", "the", "C0027203#ent", "<e1>", "isolated", "from", "HSV-1-infected", "cells", "."], "h": {"id": "C0610268", "name": "C0610268#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}}
{"token": ["Blockade", "of", "the", "ALK5", "kinase", "in", "the", "presence", "of", "C0672708#ent", "<e1>", "significantly", "inhibited", "phosphorylation", "of", "Smad", "3", "activity", "of", "C0127082#ent", "<e2>", "Shh-induced", "cell", "motility/invasiveness", "."], "h": {"id": "C0672708", "name": "C0672708#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [19, 20]}}
{"token": ["Our", "data", "show", "that", "trimethoprim/sulphamethoxazole", ",", "chloramphenicol", "and", "erythromycin", "significantly", "decrease", "C1705628#ent", "<e1>", "binding", ",", "while", "gentamicin", "and", "C0037210#ent", "<e2>", "are", "without", "effect", "."], "h": {"id": "C1705628", "name": "C1705628#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037210", "name": "C0037210#ent", "pos": [18, 19]}}
{"token": ["SB203580", "and", "PD169316", ",", "inhibitors", "of", "p38", "MAP", "kinase", "suppressed", "the", "HSP27", "accumulation", "by", "simvastatin", "while", "C1144433#ent", "<e1>", ",", "a", "negative", "control", "of", "C1120843#ent", "<e2>", "had", "no", "effect"], "h": {"id": "C1144433", "name": "C1144433#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [23, 24]}}
{"token": ["In", "contrast", ",", "C1144433#ent", "<e1>", ",", "a", "structural", "analog", "does", "not", "inhibit", "C1120843#ent", "<e2>", "was", "without", "effect", "on", "glucose", "uptake"], "h": {"id": "C1144433", "name": "C1144433#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [12, 13]}}
{"token": ["For", "example", ",", "the", "cornea", "and", "retina", "(", "but", "not", "the", "ciliary", "body", "aqueous", "or", "C0271408#ent", "<e1>", ")", "contain", "a", "46", "kDa", "IGFBP", "that", "may", "be", "C0123707#ent", "<e2>", "."], "h": {"id": "C0271408", "name": "C0271408#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0123707", "name": "C0123707#ent", "pos": [26, 27]}}
{"token": ["The", "interaction", "of", "GPIbbeta", "with", "C4284289#ent", "<e1>", "is", "essential", "for", "the", "functional", "expression", "of", "C1415186#ent", "<e2>", "."], "h": {"id": "C4284289", "name": "C4284289#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415186", "name": "C1415186#ent", "pos": [14, 15]}}
{"token": ["In", "case", "1", ",", "C4284289#ent", "<e1>", "was", "completely", "absent", "but", "residual", "amounts", "of", "C1415186#ent", "<e2>", "GPV", "were", "detectable", ";", "in", "case", "2", "C1415186#ent", "<e2>", "completely", "absent", "."], "h": {"id": "C4284289", "name": "C4284289#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415186", "name": "C1415186#ent", "pos": [13, 14]}}
{"token": ["Chinese", "hamster", "ovary", "cells", "stably", "express", "human", "GPIbbeta", "and", "C4284289#ent", "<e1>", "were", "transfected", "with", "the", "canine", "C1415186#ent", "<e2>", "cDNA", "."], "h": {"id": "C4284289", "name": "C4284289#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415186", "name": "C1415186#ent", "pos": [16, 17]}}
{"token": ["4", ")", "C1850938#ent", "<e1>", "infants", "and", "AFD", "infants", "showed", "the", "same", "level", "of", "C4283853#ent", "<e2>", "."], "h": {"id": "C1850938", "name": "C1850938#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "we", "evaluated", "levosimendan", ",", "a", "new", "drug", "developed", "for", "the", "treatment", "of", "acute", "and", "C0018801#ent", "<e1>", "as", "a", "potential", "C1422492#ent", "<e2>", "of", "ATP-sensitive", "potassium", "to", "the", "matrix", "of", "cardiac", "mitochondria"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [23, 24]}}
{"token": ["Mutations", "in", "IRAK4", "selectively", "impair", "TLRs", "other", "than", "TLR3", "and", "most", "IL-1R", "responses", ",", "and", "confer", "a", "predisposition", "to", "pyogenic", "C0004623#ent", "<e1>", "including", "invasive", "C0032269#ent", "<e2>", "particular", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [20, 21]}, "relation": "related_to", "t": {"id": "C0032269", "name": "C0032269#ent", "pos": [24, 25]}}
{"token": ["This", "C0597298#ent", "<e1>", "is", "probably", "a", "developmental", "form", "of", "C0027096#ent", "<e2>", "because", "it", "was", "transiently", "expressed", "during", "the", "development", "of", "type", "I", "extrafusal", "fibers", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [9, 10]}}
{"token": ["The", "development", "of", "cardiac", "hypertrophy", "secondary", "to", "pressure", "overload", "accompanied", "by", "C0597298#ent", "<e1>", "changes", "of", "contractile", "proteins", "as", "C0027096#ent", "<e2>", "and", "actin", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [18, 19]}}
{"token": ["Therefore", ",", "in", "patients", "with", "C0948008#ent", "<e1>", "especially", "those", "with", "C0007273#ent", "<e2>", "lacunar", "disease", ")", ",", "the", "goal", "is", "to", "prevent", "not", "only", "recurrent", "stroke", "but", "also", "coronary", "artery", "disease"], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0007273", "name": "C0007273#ent", "pos": [10, 11]}}
{"token": ["Atherosclerosis", "of", "the", "intracranial", "arteries", "a", "well-recognized", "cause", "of", "C0948008#ent", "<e1>", "Asians", ",", "and", "C0007273#ent", "<e2>", "more", "often", "seen", "in", "western", "countries"], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0007273", "name": "C0007273#ent", "pos": [14, 15]}}
{"token": ["Reduced", "cerebral", "blood", "flow", "cerebrovascular", "reactivity", "acetazolamide", "have", "been", "used", "as", "predictors", "for", "subsequent", "C0948008#ent", "<e1>", "patients", "with", "C0007273#ent", "<e2>", "called", "type", "3", "ischemia"], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0007273", "name": "C0007273#ent", "pos": [18, 19]}}
{"token": ["C0759338#ent", "<e1>", "is", "a", "novel", "anticancer", "drug", "inhibits", "C0138837#ent", "<e2>"], "h": {"id": "C0759338", "name": "C0759338#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [8, 9]}}
{"token": ["Lonafarnib", "(", "C0759338#ent", "<e1>", ")", "is", "a", "C0138837#ent", "<e2>", "FTI", ")", "that", "inhibits", "the", "post-translational", "lipid", "modification", "H-Ras", "and", "other", "farnesylated", "proteins"], "h": {"id": "C0759338", "name": "C0759338#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [7, 8]}}
{"token": ["We", "report", "four", "fatal", "cases", "of", "fulminant", "hepatitis", "B", ",", "one", "with", "C0011226#ent", "<e1>", "one", "with", "C3854222#ent", "<e2>", "HIV", ")", "infection", ",", "in", "young", ",", "sexually", "active", "heterosexual", "crack", "users", "."], "h": {"id": "C0011226", "name": "C0011226#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [16, 17]}}
{"token": ["The", "prevalence", "of", "serum", "markers", "C0011226#ent", "<e1>", "determined", "prospectively", "in", "82", "intravenous", "drug", "abusers", "various", "stages", "of", "C3854222#ent", "<e2>", "HIV", ")", "disease", "."], "h": {"id": "C0011226", "name": "C0011226#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [17, 18]}}
{"token": ["We", "used", "the", "polymerase", "chain", "reaction", "PCR", ")", "to", "detect", "C0011226#ent", "<e1>", "HD", ")", "viremia", "in", "patients", "infected", "with", "the", "C3854222#ent", "<e2>", "HIV", ")", "."], "h": {"id": "C0011226", "name": "C0011226#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [20, 21]}}
{"token": ["Pre-", "and", "postsynaptic", "muscarinic", "receptors", "to", "the", "ability", "of", "the", "C3536931#ent", "<e1>", "scopolamine", ",", "to", "augment", "D1", "receptor-stimulated", "immediate", "early", "and", "C1334960#ent", "<e2>", "expression", "."], "h": {"id": "C3536931", "name": "C3536931#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334960", "name": "C1334960#ent", "pos": [21, 22]}}
{"token": ["C0001126#ent", "<e1>", "confirmed", "by", "C0074722#ent", "<e2>", "ammonium", "chloride", "loading", "test"], "h": {"id": "C0001126", "name": "C0001126#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0074722", "name": "C0074722#ent", "pos": [4, 5]}}
{"token": ["C3898066#ent", "<e1>", "not", "reveal", "any", "significant", "group", "differences", "regarding", "laryngitis", ",", "C0031350#ent", "<e2>", ",", "or", "rhinitis", "."], "h": {"id": "C3898066", "name": "C3898066#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [11, 12]}}
{"token": ["Its", "ability", "to", "degrade", "C1414382#ent", "<e1>", "at", "pH", "6.5", "is", "slightly", "greater", "than", "that", "of", "C3538705#ent", "<e2>", ",", "but", "it", "is", "less", "active", "than", "C3538705#ent", "<e2>", "at", "pH", "7.4", "or", "8.9", "."], "h": {"id": "C1414382", "name": "C1414382#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538705", "name": "C3538705#ent", "pos": [15, 16]}}
{"token": ["Mass", "spectrometry", "permitted", "the", "identification", "of", "C1419257#ent", "<e1>", "as", "an", "interacting", "and", "C0086903#ent", "<e2>", "the", "VRK", "serine-threonine", "kinase", "activities"], "h": {"id": "C1419257", "name": "C1419257#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "C0026289#ent", "<e1>", "significantly", "reduces", "the", "incidence", "of", "C0004238#ent", "<e2>", "after", "CABG", "."], "h": {"id": "C0026289", "name": "C0026289#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [10, 11]}}
{"token": ["But", "in", "proliferated", "muscle", "cells", "C1826724#ent", "<e1>", "inhibition", "results", "in", "C0059239#ent", "<e2>", "and", "Cas", "tyrosine", "dephosphorylation"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [10, 11]}}
{"token": ["The", "hyperimmunoglobulinemia", "D", "periodic", "fever", "syndrome", "C0342731#ent", "<e1>", ")", ",", "one", "of", "the", "C2698414#ent", "<e2>", "is", "caused", "by", "mutations", "in", "the", "gene", "coding", "mevalonate", "kinase", "MVK", ")", "."], "h": {"id": "C0342731", "name": "C0342731#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "short-term", "exposure", "to", "dietary", "C1335238#ent", "<e1>", "inhibits", "cancer", "metastasis", "whereas", "consistent", "exposure", "to", "C1420423#ent", "<e2>", "provides", "quiescent/dormant", "status", "with", "possible", "induction", "of", "cancer", "stem", "progenitor", "phenotype", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [15, 16]}}
{"token": ["Western", "blotting", "an", "increased", "expression", "of", "C1335238#ent", "<e1>", "in", "cells", "treated", "with", "conditioned", "medium", "with", "C1420423#ent", "<e2>", "alone", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [15, 16]}}
{"token": ["Trans-10,cis-12", "CLA", "treatment", "of", "preadipocyte", "cultures", "for", "48", "h", "increased", "C1335238#ent", "<e1>", "PPARgamma2", ")", "protein", "expression", "compared", "to", "cultures", "treated", "with", "linoleic", "acid", "C1420423#ent", "<e2>", ")", "or", "the", "BSA", "controls", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [23, 24]}}
{"token": ["C3b", "binding", "was", "enhanced", "by", "treatment", "of", "C4282316#ent", "<e1>", "or", "gC-2", "with", "C0027803#ent", "<e2>", "."], "h": {"id": "C4282316", "name": "C4282316#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027803", "name": "C0027803#ent", "pos": [12, 13]}}
{"token": ["C1522712#ent", "<e1>", "IP-10", ")", "and", "monokine", "induced", "by", "IFN-gamma", "(", "C1707170#ent", "<e2>", ")", "are", "related", "CXC", "chemokines", "which", "bind", "to", "the", "CXCR3", "receptor", "specifically", "target", "activated", "T", "lymphocytes", "natural", "killer", "NK", ")", "cells", "."], "h": {"id": "C1522712", "name": "C1522712#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1707170", "name": "C1707170#ent", "pos": [10, 11]}}
{"token": ["This", "study", "extends", "previous", "work", "on", "inhibitors", "of", "the", "shikimate", "pathway", ",", "by", "examining", "their", "interaction", "with", "the", "C0003374#ent", "<e1>", "pyrimethamine", "and", "C0165603#ent", "<e2>", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [18, 19]}, "relation": "therapeutic_class_of", "t": {"id": "C0165603", "name": "C0165603#ent", "pos": [22, 23]}}
{"token": ["Proguanil", "emerged", "as", "the", "most", "promising", "of", "the", "current", "C0003374#ent", "<e1>", "as", "a", "partner", "for", "C0165603#ent", "<e2>", "in", "a", "fixed", "combination", ",", "with", "tetracycline", "as", "back-up", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [9, 10]}, "relation": "therapeutic_class_of", "t": {"id": "C0165603", "name": "C0165603#ent", "pos": [15, 16]}}
{"token": ["Additional", "clones", "that", "were", "resistant", "to", "some", "(", "but", "not", "all", ")", "traditional", "C0003374#ent", "<e1>", "resistance", "to", "C0165603#ent", "<e2>", "at", "high", "frequency", "but", "not", "to", "5-fluoroorotate", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0165603", "name": "C0165603#ent", "pos": [17, 18]}}
{"token": ["Among", "pineal-intact", "hamsters", ",", "C0015967#ent", "<e1>", "and", "behavioral", "responses", "LPS", "were", "attenuated", "in", "SD", "relative", "to", "C1414435#ent", "<e2>", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414435", "name": "C1414435#ent", "pos": [16, 17]}}
{"token": ["These", "data", "suggest", "that", "in", "man", "a", "C0242898#ent", "<e1>", "mechanism", "is", "involved", "in", "the", "regulation", "of", "the", "C1705587#ent", "<e2>", "response", "to", "ANG", "II", "but", "not", "in", "the", "mediation", "of", "poglycemia-induced", "C1705587#ent", "<e2>", "release", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705587", "name": "C1705587#ent", "pos": [17, 18]}}
{"token": ["Levels", "of", "hormone", "(", "E2,P", ",", "LH", ",", "C0016424#ent", "<e1>", ")", "were", "compared", "in", "C0014921#ent", "<e2>", "with", "normal", "women", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014921", "name": "C0014921#ent", "pos": [14, 15]}}
{"token": ["Soluble", "IL2R", "was", "measured", "by", "enzyme-linked", "immunosorbent", "assay", "the", "serum", "of", "16", "children", "with", "autoimmune", "chronic", "active", "hepatitis", "eight", "with", "chronic", "liver", "disease", "to", "hepatitis", "B", "virus", "infection", "seven", "with", "C0019202#ent", "<e1>", "nine", "with", "C0221757#ent", "<e2>", "and", "15", "healthy", "age", "controls", "."], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [30, 31]}, "relation": "NA", "t": {"id": "C0221757", "name": "C0221757#ent", "pos": [34, 35]}}
{"token": ["Twelve", "selected", "patients", "were", "investigated", ",", "comprising", "five", "with", "inflammatory", "bowel", "disease", "one", "with", "C0018213#ent", "<e1>", "one", "with", "C0008313#ent", "<e2>", "one", "with", "Sj\u00f6gren's", "syndrome", "one", "with", "rheumatoid", "arthritis", "one", "with", "systemic", "lupus", "erythematosus", "two", "with", "myasthenia", "gravis"], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0008313", "name": "C0008313#ent", "pos": [18, 19]}}
{"token": ["The", "50-kDa", "C1413868#ent", "<e1>", "is", "routed", "through", "the", "constitutive", "secretory", "pathway", "processed", "by", "C0919550#ent", "<e2>", "or", "a", "furin-like", "enzyme", "into", "the", "37-kDa", "active", "form", "and", "secreted", "into", "the", "extracellular", "matrix"], "h": {"id": "C1413868", "name": "C1413868#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [13, 14]}}
{"token": ["To", "evaluate", "relapse", "of", "acute", "pancreatitis", "patients", "with", "C0747195#ent", "<e1>", "whom", "coexisting", "C0012634#ent", "<e2>", "or", "patient", "refusal", "have", "excluded", "cholecystectomy", "."], "h": {"id": "C0747195", "name": "C0747195#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}}
{"token": ["We", "tested", "the", "ability", "of", "RSM28", "-", "1", "to", "suppress", "a", "variety", "of", "C1705323#ent", "<e1>", "and", "cox3", "mutations", "and", "found", "that", "initiation", "codon", "mutations", "both", "C1417679#ent", "<e2>", "were", "suppressed", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [25, 26]}}
{"token": ["The", "C1418864#ent", "<e1>", "in", "the", "C0053546#ent", "<e2>", "production", "was", "about", "35", "kb", "long", "."], "h": {"id": "C1418864", "name": "C1418864#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0053546", "name": "C0053546#ent", "pos": [5, 6]}}
{"token": ["C1567710#ent", "<e1>", "and", "Ku80", "immunoreactivity", "increased", "markedly", "after", "C0007787#ent", "<e2>", "C1567710#ent", "<e1>", "particularly", "in", "the", "regions", "of", "greatest", "susceptibility", "to", "hypoxic", "injury", "the", "CA1", "field", "the", "hippocampus", "and", "the", "depths", "of", "neocortical", "sulci", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [8, 9]}}
{"token": ["Two", "\"", "new", "\"", "phenotypes", "of", "the", "C0014894#ent", "<e1>", "named", "C0023381#ent", "<e2>", "1", "and", "C0023381#ent", "<e2>", "2", ",", "were", "observed", "in", "a", "father", "and", "his", "daughter", ",", "respectively", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023381", "name": "C0023381#ent", "pos": [10, 11]}}
{"token": ["In", "an", "interspecific", "backcross", "involving", "Mus", "spretus", "Rb-1", "and", "the", "murine", "homolog", "of", "the", "human", "C0014894#ent", "<e1>", "ESD", ")", ",", "which", "we", "refer", "to", "here", "as", "C0023381#ent", "<e2>", ",", "were", "inseparable", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0023381", "name": "C0023381#ent", "pos": [26, 27]}}
{"token": ["C0152915#ent", "<e1>", "another", "potential", "cause", "of", "severe", "C1145670#ent", "<e2>", "respiratory", "secretions", "be", "routinely", "examined", "for", "acid-fast", "bacilli", "AIDS", "patients", "with", "pulmonary", "infiltrates"], "h": {"id": "C0152915", "name": "C0152915#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [7, 8]}}
{"token": ["We", "reported", "a", "survival", "case", "a", "78-year-old", "female", "with", "C0152915#ent", "<e1>", "complicated", "with", "severe", "C1145670#ent", "<e2>", "pancytopenia", ",", "DIC", ",", "drug", "induced", "fever", "and", "pneumothorax", "."], "h": {"id": "C0152915", "name": "C0152915#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [14, 15]}}
{"token": ["Two", "C0991617#ent", "<e1>", "not", "commonly", "thought", "of", "as", "causes", "of", "C4050247#ent", "<e2>", "in", "children", "(", "rhinoviruses", ",", "coronaviruses", ")", "should", "now", "be", "added", "to", "an", "already", "long", "list"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4050247", "name": "C4050247#ent", "pos": [10, 11]}}
{"token": ["In", "this", "bsMAb", ",", "one", "arm", "could", "react", "with", "C1423571#ent", "<e1>", "and", "the", "other", "with", "a", "hapten", "C0950779#ent", "<e2>", "."], "h": {"id": "C1423571", "name": "C1423571#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0950779", "name": "C0950779#ent", "pos": [17, 18]}}
{"token": ["A", "case", "of", "a", "C0031024#ent", "<e1>", "to", "a", "C0275524#ent", "<e2>", "a", "yeast", ",", "Candida", "guilliermondii", "two", "other", "oral", "bacteria", "described", "."], "h": {"id": "C0031024", "name": "C0031024#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [8, 9]}}
{"token": ["We", "report", "two", "cases", "of", "idiopathic", "intracranial", "hypertension", "chronic", "daily", "headache", "C1112466#ent", "<e1>", "features", "in", "the", "absence", "of", "associated", "C0030353#ent", "<e2>", "."], "h": {"id": "C1112466", "name": "C1112466#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030353", "name": "C0030353#ent", "pos": [19, 20]}}
{"token": ["In", "refractory", "CDH", "with", "C1112466#ent", "<e1>", "features", ",", "a", "spinal", "tap", "exclude", "coexistent", "idiopathic", "intracranial", "hypertension", "C0030353#ent", "<e2>", "may", "be", "indicated", "."], "h": {"id": "C1112466", "name": "C1112466#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030353", "name": "C0030353#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "suggest", "that", "C1332447#ent", "<e1>", "polymorphisms", "are", "related", "to", "C1705568#ent", "<e2>", "risk", ",", "and", "highlight", "the", "importance", "of", "the", "MHC", "in", "the", "development", "of", "this", "disease", "."], "h": {"id": "C1332447", "name": "C1332447#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705568", "name": "C1705568#ent", "pos": [10, 11]}}
{"token": ["Four", "postmarketing", "surveillance", "studies", "conducted", "with", "patients", "who", "had", "OA", "and", "C0003873#ent", "<e1>", "to", "further", "assess", "the", "safety", "of", "C0059865#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0059865", "name": "C0059865#ent", "pos": [19, 20]}}
{"token": ["The", "subjects", "were", "categorised", "as", "having", "an", "acute-onset", "C0015674#ent", "<e1>", "a", "non-specific", "chronic", "fatigue", "possible", "C0026848#ent", "<e2>", "view", "of", "pronounced", "myalgia", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [15, 16]}}
{"token": ["FAT", "is", "based", "on", "the", "property", "of", "C1879974#ent", "<e1>", "to", "agglutinate", "fat", "emulsions", "in", "the", "presence", "of", "C1705551#ent", "<e2>", "."], "h": {"id": "C1879974", "name": "C1879974#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705551", "name": "C1705551#ent", "pos": [17, 18]}}
{"token": ["The", "binding", "was", "not", "inhibited", "by", "ethylenediaminetetraacetate", "(", "EDTA", ")", "but", "could", "be", "inhibited", "by", "C1705551#ent", "<e1>", ",", "whereas", "C1879974#ent", "<e2>", "binding", "to", "PC-Sepharose", "was", "inhibited", "by", "EDTA", "and", "required", "C1705551#ent", "<e1>", "."], "h": {"id": "C1879974", "name": "C1879974#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705551", "name": "C1705551#ent", "pos": [15, 16]}}
{"token": ["To", "define", "the", "prevalence", "of", "extracolonic", "gastrointestinal", "tract", "neoplasms", "association", "with", "C0017097#ent", "<e1>", "17", "patients", "with", "the", "C1848862#ent", "<e2>", "underwent", "a", "systematic", "endoscopic", "radiologic", "investigation"], "h": {"id": "C0017097", "name": "C0017097#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [17, 18]}}
{"token": ["However", ",", "a", "number", "of", "recent", "studies", "suggest", "that", "adult", "spinal", "cord", "neurotrophin", "receptors", "responds", "to", "the", "C1332408#ent", "<e1>", ",", "brain-derived", "neurotrophic", "factor", "BDNF", ")", "and", "neurotrophin", "3", "C1417860#ent", "<e2>", ")", ",", "particularly", "after", "injury", "."], "h": {"id": "C1332408", "name": "C1332408#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417860", "name": "C1417860#ent", "pos": [28, 29]}}
{"token": ["Its", "ability", "to", "degrade", "C0013765#ent", "<e1>", "confirmed", ",", "and", "the", "three", "sites", "of", "cleavage", "within", "C1414382#ent", "<e2>", "help", "define", "a", "new", "family", "of", "elastases", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [15, 16]}}
{"token": ["In", "particular", ",", "the", "expression", "of", "Bcl-2", "mRNA", ",", "including", "C4042483#ent", "<e1>", "in", "male", "rats", "were", "significantly", "suppressed", "by", "C0813872#ent", "<e2>", "treatment", "."], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [19, 20]}}
{"token": ["Because", "cellular", "and", "physiological", "stress", "associated", "with", "induction", "of", "both", "C0162508#ent", "<e1>", "and", "C3813609#ent", "<e2>", "it", "is", "apparent", "that", "C3813609#ent", "<e2>", "may", "play", "a", "modulatory", "role", "in", "the", "regulation", "of", "C0162508#ent", "<e1>", "responsive", "genes", "."], "h": {"id": "C3813609", "name": "C3813609#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [10, 11]}}
{"token": ["Experiments", "on", "cellular", "transcription", "factors", "from", "the", "rat", "adrenal", "gland", "now", "shown", "that", "C3813609#ent", "<e1>", "modulate", "in", "vitro", "DNA", "binding", "of", "the", "C0162508#ent", "<e2>"], "h": {"id": "C3813609", "name": "C3813609#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [22, 23]}}
{"token": ["C1412228#ent", "<e1>", "deposit", "densities", "in", "B17", "and", "C3470196#ent", "<e2>", "were", "positively", "correlated", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3470196", "name": "C3470196#ent", "pos": [7, 8]}}
{"token": ["Recently", ",", "partial", "deletions", "involving", "both", "the", "type", "1", "inositol", "1,4,5-triphosphate", "receptor", "ITPR1", ")", "and", "sulfatase", "modifying", "factor", "1", "SUMF1", ")", "C0017337#ent", "<e1>", "have", "been", "identified", "in", "Australian", "and", "British", "families", "C1705860#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705860", "name": "C1705860#ent", "pos": [31, 32]}}
{"token": ["The", "sugar", "moiety", "of", "this", "enzyme", "bore", "greater", "resemblance", "to", "that", "of", "kidney", "C1424288#ent", "<e1>", "than", "C0023899#ent", "<e2>", "or", "bone", "C1424288#ent", "<e1>", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1424288", "name": "C1424288#ent", "pos": [13, 14]}}
{"token": ["Formation", "of", "lamellipodial", "structures", "C1706331#ent", "<e1>", "was", "inhibited", "in", "C1421480#ent", "<e2>", "KO", "MEFs", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421480", "name": "C1421480#ent", "pos": [9, 10]}}
{"token": ["The", "C0027203#ent", "<e1>", "transferred", "[3H]methyl", "to", "geranylgeranylated", "Rab3A", "but", "not", "to", "geranylgeranylated", "C1419187#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419187", "name": "C1419187#ent", "pos": [12, 13]}}
{"token": ["In", "order", "to", "establish", "a", "gene", "transfer", "system", "yeast", "by", "promiscuous", "conjugation", ",", "we", "constructed", "plasmid", "pAY101", "which", "contained", "an", "oriT", "sequence", "from", "C2346566#ent", "<e1>", "(", "IncP", ")", "and", "the", "C3811247#ent", "<e2>", "ARS1", "genes"], "h": {"id": "C2346566", "name": "C2346566#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3811247", "name": "C3811247#ent", "pos": [30, 31]}}
{"token": ["C0289313#ent", "<e1>", "production", "was", "blocked", "by", "actinomycin", "D", "cycloheximide", ",", "and", "C0033607#ent", "<e2>", "suggesting", "that", "C0289313#ent", "<e1>", "generation", "is", "downstream", "of", "new", "mRNA", "and", "protein", "synthesis", "activation", "of", "caspases", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [0, 1]}}
{"token": ["Several", "neurological", "disorders", "C0026769#ent", "<e1>", "myasthenia", "gravis", "epilepsy", ",", "spinal", "cord", "injury", "and", "C0038525#ent", "<e2>", "encountered", "with", "increasing", "frequency", "in", "pregnant", "women", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [13, 14]}}
{"token": ["Overexpression", "of", "C0009225#ent", "<e1>", "induces", "apoptosis", "via", "a", "pathway", "involving", "activation", "of", "C0010656#ent", "<e2>", ",", "since", "caspase", "inhibitors", "XIAP", "and", "an", "inactive", "mutant", "of", "caspase-9", "block", "apoptosis", "."], "h": {"id": "C0009225", "name": "C0009225#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [12, 13]}}
{"token": ["C4049878#ent", "<e1>", "and", "C0393808#ent", "<e2>", "formed", "muscle", "tissue", "produced", "better", "heart", "function", "the", "cardiomyopathic", "hearts", "and", "C4049878#ent", "<e1>", "showed", "better", "systolic", "and", "developed", "pressures", "than", "C0393808#ent", "<e2>", ",", "even", "though", "they", "were", "similar", "in", "other", "functions", "."], "h": {"id": "C0393808", "name": "C0393808#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4049878", "name": "C4049878#ent", "pos": [0, 1]}}
{"token": ["The", "selective", "regulation", "of", "C1335273#ent", "<e1>", "tyrosine", "phosphorylation", "by", "C0812303#ent", "<e2>", "in", "vivo", "correlated", "with", "the", "preferential", "phosphorylation", "of", "C1335273#ent", "<e1>", "by", "C0812303#ent", "<e2>", "in", "vitro"], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812303", "name": "C0812303#ent", "pos": [9, 10]}}
{"token": ["Zebrafish", "expressed", "orthologs", "of", "cannabinoid", "receptor", "1", "transient", "receptor", "potential", "channel", "vanilloid", "receptor", "4", "GPR55", "receptor", ",", "fatty", "acid", "amide", "hydrolase", "1", "monoacylglycerol", "lipase", "NAPE-selective", "phospholipase", "D", "abhydrolase", "domain-containing", "protein", "4", "and", "C0023816#ent", "<e1>", "beta", ";", "and", "paired", "paralogs", "of", "C1413555#ent", "<e2>", "fatty", "acid", "amide", "hydrolase", "2", "peroxisome", "proliferator-activated", "receptor", "alpha", "prostaglandin-endoperoxide", "synthase", "2", "and", "transient", "receptor", "potential", "cation", "channel", "subtype", "A1"], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [32, 33]}, "relation": "NA", "t": {"id": "C1413555", "name": "C1413555#ent", "pos": [40, 41]}}
{"token": ["The", "predicted", "amino", "acid", "sequence", "C1704966#ent", "<e1>", "differs", "significantly", "from", "the", "partial", "AFX", "protein", "sequence", "previously", "(", "C1417679#ent", "<e2>", ",", "Chromosomes", "and", "Cancer", ",", "1994", ",", "11", ",", "79", "-", "84", ")", "."], "h": {"id": "C1704966", "name": "C1704966#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["It", "codes", "for", "a", "chimeric", "protein", "of", "MLL", "fused", "to", "C1704966#ent", "<e1>", ",", "a", "forkhead", "transcription", "factor", "normally", "regulates", "C1417679#ent", "<e2>", "involved", "in", "apoptosis", "and", "cell", "cycle", "progression"], "h": {"id": "C1704966", "name": "C1704966#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [19, 20]}}
{"token": ["In", "biosynthesis", "of", "heparan", "sulfate", "HS", ")", ",", "a", "structurally", "related", "polysaccharide", ",", "HS", "glucuronyl", "C5-epimerase", "(", "C3540642#ent", "<e1>", ")", "converts", "D-glucuronic", "acid", "GlcA", ")", "to", "C0020818#ent", "<e2>", "IdoA", ")", "residues", "."], "h": {"id": "C3540642", "name": "C3540642#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020818", "name": "C0020818#ent", "pos": [26, 27]}}
{"token": ["ZNF191", ",", "a", "new", "human", "C1421587#ent", "<e1>", "probably", "relates", "to", "some", "C0015398#ent", "<e2>", "cancers", "."], "h": {"id": "C1421587", "name": "C1421587#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015398", "name": "C0015398#ent", "pos": [11, 12]}}
{"token": ["To", "elucidate", "the", "relationship", "between", "these", "intracellular", "proteins", "acute", "otitis", "media", "C2698738#ent", "<e1>", ")", ",", "the", "authors", "studied", "C3890018#ent", "<e2>", "production", "in", "guinea", "pigs", "with", "C2698738#ent", "<e1>", "induced", "by", "inoculation", "of", "Streptococcus", "pneumoniae", "the", "middle", "ear"], "h": {"id": "C2698738", "name": "C2698738#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [18, 19]}}
{"token": ["C1704347#ent", "<e1>", "also", "been", "proposed", "to", "promote", "pain", "hypersensitivity", "activating", "the", "proteinase-activated", "receptor", "2", "C1539608#ent", "<e2>", ")", "that", "is", "expressed", "on", "nociceptive", "neurons"], "h": {"id": "C1704347", "name": "C1704347#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539608", "name": "C1539608#ent", "pos": [14, 15]}}
{"token": ["The", "scores", "of", "14", "women", "with", "C0268528#ent", "<e1>", "on", "the", "C1457887#ent", "<e2>", "the", "Symptom", "Questionnaire", "compared", "with", "those", "of", "nonpsychotic", "women", "attending", "a", "psychiatric", "clinic", "women", "attending", "a", "family", "practice", "clinic", "and", "female", "nonpatient", "employees"], "h": {"id": "C0268528", "name": "C0268528#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [10, 11]}}
{"token": ["After", "pars", "plana", "vitrectomy", "fluid-gas", "exchange", ",", "two", "patients", "developed", "fibrin", "membranes", "the", "C0026961#ent", "<e1>", "in", "pupillary", "block", "subsequent", "C0017601#ent", "<e2>", "."], "h": {"id": "C0026961", "name": "C0026961#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [19, 20]}}
{"token": ["Definitive", "evidence", "exists", "for", "protection", "against", "ovarian", "and", "endometrial", "cancers", "benign", "breast", "disease", "C0242172#ent", "<e1>", "hospitalization", ",", "ectopic", "pregnancy", "and", "C0162316#ent", "<e2>"], "h": {"id": "C0242172", "name": "C0242172#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "C0661946#ent", "<e1>", "mRNA", "is", "translated", "in", "tumor", "cells", "an", "apparently", "C0669365#ent", "<e2>", "way", "."], "h": {"id": "C0661946", "name": "C0661946#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}}
{"token": ["On", "differentiation", ",", "the", "tau/tubulin", "ratio", "increased", "about", "3-fold", "regardless", "whether", "cells", "were", "optimally", "differentiated", "with", "C0022265#ent", "<e1>", "C0085171#ent", "<e2>", "or", "with", "C0022265#ent", "<e1>", "which", "does", "not", "inhibit", "proliferation", "."], "h": {"id": "C0085171", "name": "C0085171#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [16, 17]}}
{"token": ["To", "address", "its", "role", "in", "vivo", "we", "generated", "transgenic", "mice", "C0669365#ent", "<e1>", "expressed", "active", "C1335590#ent", "<e2>", "within", "the", "T", "cell", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335590", "name": "C1335590#ent", "pos": [14, 15]}}
{"token": ["Mirtazapine", "and", "C0171023#ent", "<e1>", "frequently", "give", "potent", "nausea", "reduction", "appetite", "increase", "in", "advanced", "C0596240#ent", "<e2>"], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0596240", "name": "C0596240#ent", "pos": [13, 14]}}
{"token": ["Histopathological", "material", "10", "patients", "with", "thalassaemia", "intermedia", "14", "with", "sickle", "cell", "thalassaemia", "18", "with", "C0037889#ent", "<e1>", "examined", "in", "order", "to", "investigate", "the", "specificity", "of", "the", "C0852949#ent", "<e2>", "."], "h": {"id": "C0037889", "name": "C0037889#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0852949", "name": "C0852949#ent", "pos": [25, 26]}}
{"token": ["We", "have", "analyzed", "uPAR", "expression", "in", "nine", "leukemic", "cell", "lines", "distinct", "lineages", "and", "maturational", "states", "correlated", "this", "with", "expression", "of", "C1367553#ent", "<e1>", "tissue-type", "plasminogen", "activator", "tPA", ")", "receptors", "and", "LDL", "receptor-related", "protein", "C1419111#ent", "<e2>", ")", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1419111", "name": "C1419111#ent", "pos": [32, 33]}}
{"token": ["Mutations", "in", "both", "C1336624#ent", "<e1>", "and", "TGFBR2", "are", "associated", "with", "C2697932#ent", "<e2>", "LDS", ")", "."], "h": {"id": "C1336624", "name": "C1336624#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697932", "name": "C2697932#ent", "pos": [10, 11]}}
{"token": ["Tip60", "(", "C1336577#ent", "<e1>", "60", "kDa", ")", ",", "a", "cellular", "protein", "intrinsic", "C0062773#ent", "<e2>", ",", "is", "involved", "in", "DNA", "damage", "repair", "apoptosis", "."], "h": {"id": "C1336577", "name": "C1336577#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [12, 13]}}
{"token": ["The", "first", "appearing", "degradation", "product", "was", "C1517683#ent", "<e1>", "which", "was", "converted", "via", "the", "deaminated", "selenoxide", "to", "C0067320#ent", "<e2>", "seleninic", "acid", "selenite", "."], "h": {"id": "C1517683", "name": "C1517683#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0067320", "name": "C0067320#ent", "pos": [16, 17]}}
{"token": ["The", "C0031678#ent", "<e1>", "cyclosporine", "A", "which", "blocks", "KC", "terminal", "differentiation", ",", "also", "blocked", "C1413210#ent", "<e2>", "expression", "by", "cultured", "KC", "."], "h": {"id": "C0031678", "name": "C0031678#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413210", "name": "C1413210#ent", "pos": [13, 14]}}
{"token": ["C0034155#ent", "<e1>", "known", "to", "occur", "as", "a", "secondary", "complication", "primary", "renal", "diseases", "specifically", "of", "C4053959#ent", "<e2>", "membranous", "glomerulonephritis", "and", "focal", "segmental", "glomerulosclerosis"], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [14, 15]}}
{"token": ["The", "eukaryotic", "cytosol", "not", "contain", "GrpE", "per", "se", "because", "GrpE-like", "function", "is", "provided", "by", "the", "C1332371#ent", "<e1>", "which", "acts", "as", "a", "C1822725#ent", "<e2>", "cytosolic", "Hsp70s", "."], "h": {"id": "C1332371", "name": "C1332371#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1822725", "name": "C1822725#ent", "pos": [21, 22]}}
{"token": ["Ninety-one", "patients", "with", "a", "diagnosis", "of", "severe", "C0004626#ent", "<e1>", "who", "underwent", "C1539092#ent", "<e2>", ",", "have", "been", "included", "in", "the", "study", "."], "h": {"id": "C0004626", "name": "C0004626#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539092", "name": "C1539092#ent", "pos": [11, 12]}}
{"token": ["PD98059", ",", "a", "MEK-1", "inhibitor", "prevented", "the", "Ang", "II-dependent", "phosphorylation", "of", "C0600388#ent", "<e1>", "2", "and", "increase", "in", "C1328053#ent", "<e2>", "expression", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [17, 18]}}
{"token": ["The", "results", "of", "this", "analysis", "are", "in", "agreement", "with", "previously", "published", "C0014921#ent", "<e1>", "data", "on", "the", "C0225326#ent", "<e2>", "length", "of", "subgroup", "F", "adenoviruses", "."], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [16, 17]}}
{"token": ["Operon", "fusions", "C1421976#ent", "<e1>", "were", "used", "to", "analyze", "expression", "from", "C1412126#ent", "<e2>", "and", "IRP2", "in", "Escherichia", "coli"], "h": {"id": "C1421976", "name": "C1421976#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412126", "name": "C1412126#ent", "pos": [10, 11]}}
{"token": ["DNA", "sequencing", "data", "indicate", "that", "C1419428#ent", "<e1>", "contains", "a", "potential", "DNA-binding", "domain", "suggesting", "that", "C1419428#ent", "<e1>", "may", "function", "as", "a", "C0086903#ent", "<e1>"], "h": {"id": "C1419428", "name": "C1419428#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [20, 21]}}
{"token": ["The", "conserved", "glutamate", "may", "act", "as", "a", "general", "base", "in", "nucleotide", "polymerization", "primases", "and", "in", "strand", "rejoining", "by", "C1336767#ent", "<e1>", "and", "as", "a", "general", "acid", "strand", "cleavage", "C1336767#ent", "<e1>", "and", "C0035542#ent", "<e1>", "."], "h": {"id": "C1336767", "name": "C1336767#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [30, 31]}}
{"token": ["The", "effects", "of", "intravenous", "infusions", "potassium", "chloride", "potassium", "acetate", "potassium", "aspartate", "potassium", "malate", "plasma", "electrolytes", "acid-base", "balance", "investigated", "in", "C0268445#ent", "<e1>", "or", "hypokalemic", "C0002062#ent", "<e2>", "rats", "."], "h": {"id": "C0268445", "name": "C0268445#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [23, 24]}}
{"token": ["(+)-Catechin", "had", "a", "higher", "tannin", "specific", "activity", "(", "TSA", ")", "for", "C1367466#ent", "<e1>", "than", "(-)-epicatechin", "(", "1.45", "versus", "0.65", "nephelos", "turbidity", "of", "C0071649#ent", "<e2>", ")", "."], "h": {"id": "C1367466", "name": "C1367466#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0071649", "name": "C0071649#ent", "pos": [22, 23]}}
{"token": ["ISTA", "believes", "that", "an", "injection", "of", "C1615183#ent", "<e1>", "causes", "the", "C0271408#ent", "<e2>", "to", "liquefy", ",", "thereby", "promoting", "the", "clearance", "of", "vision-distorting", "blood", "."], "h": {"id": "C1615183", "name": "C1615183#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0271408", "name": "C0271408#ent", "pos": [10, 11]}}
{"token": ["More", "recently", "these", "results", "have", "been", "confirmed", "by", "other", "researchers", ",", "and", "several", "studies", "have", "shown", "higher", "recurrence", "rates", "of", "C0009450#ent", "<e1>", "as", "hepatitis", "B", "C", "and", "C0010823#ent", "<e2>", "HLA-compatible", "liver", "transplants"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [27, 28]}}
{"token": ["All", "7", "cases", "with", "detectable", "immune", "complexes", "with", "various", "concomitant", "neoplastic", "(", "renal", "carcinoma", "Kaposi", "sarcoma", "or", "C0009450#ent", "<e1>", "pneumonia", ",", "septicaemia", ",", "Herpes", "zoster", "C0010823#ent", "<e2>", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [25, 26]}}
{"token": ["Host", "resistance", "cytomegalovirus", "infections", "the", "rat", "was", "determined", "by", "titrating", "C0009450#ent", "<e1>", "levels", "in", "organs", "after", "C0010823#ent", "<e2>", "an", "in", "vitro", "infectivity", "test", "as", "the", "Plaque", "Forming", "Unit", "PFU", ")", "Test", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [16, 17]}}
{"token": ["Single", "application", "Nix", "(", "permethrin", "1", "%", "creme", "rinse", ")", "and", "C0073361#ent", "<e1>", "were", "compared", "as", "treatments", "for", "C0030756#ent", "<e2>", "435", "patients", ",", "the", "majority", "of", "whom", "were", "children", "."], "h": {"id": "C0073361", "name": "C0073361#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030756", "name": "C0030756#ent", "pos": [18, 19]}}
{"token": ["Seven", "days", "after", "the", "initial", "visit", ",", "NIX", "was", "determined", "to", "be", "significantly", "better", "than", "C0073361#ent", "<e1>", "for", "eradicating", "the", "C0030756#ent", "<e2>", "infestation", "."], "h": {"id": "C0073361", "name": "C0073361#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030756", "name": "C0030756#ent", "pos": [20, 21]}}
{"token": ["In", "this", "study", ",", "transdermal", "discs", "C0017887#ent", "<e1>", "were", "given", "to", "14", "patients", "with", "acute", "myocardial", "infarction", "C0340293#ent", "<e2>", ")", "and", "mild", "hemodynamic", "impairment", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [17, 18]}}
{"token": ["In", "treated", "rats", "the", "C1455430#ent", "<e1>", "epithelium", "had", "lost", "the", "structural", "characteristics", "of", "C3536863#ent", "<e2>", "transporting", "epithelia", "and", "the", "cells", "were", "in", "different", "stages", "of", "apoptosis", "."], "h": {"id": "C1455430", "name": "C1455430#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [13, 14]}}
{"token": ["C0002726#ent", "<e1>", "is", "the", "collective", "term", "for", "a", "group", "ofuncommon", "C0025517#ent", "<e2>", "which", "insoluble", "amyloid", "protein-fibres", "are", "deposited", "in", "tissues", "and", "organs", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [10, 11]}}
{"token": ["C0002726#ent", "<e1>", "is", "a", "C0025517#ent", "<e2>", "which", "amyloid", "protein", "deposited", "in", "various", "organs", "and", "destroys", "them", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}}
{"token": ["C0006938#ent", "<e1>", ",", "a", "kininase", "inhibitor", "potentiated", "the", "C0013604#ent", "<e2>", "by", "a", "low", "dose", "cardiotoxin", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [8, 9]}}
{"token": ["Together", ",", "our", "results", "provide", "the", "genetic", "evidence", "C1412552#ent", "<e1>", "as", "a", "positive", "regulator", "in", "NF-kappaB", "signaling", "pathway", "connecting", "CARMA3", "to", "C3890198#ent", "<e2>", "."], "h": {"id": "C1412552", "name": "C1412552#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3890198", "name": "C3890198#ent", "pos": [21, 22]}}
{"token": ["Our", "current", "results", "demonstrated", "that", "the", "binding", "of", "Mdm2", "to", "C1412552#ent", "<e1>", "significantly", "enhanced", "by", "stimulation", "of", "C3890198#ent", "<e2>", "."], "h": {"id": "C1412552", "name": "C1412552#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3890198", "name": "C3890198#ent", "pos": [17, 18]}}
{"token": ["Oncoprotein", "Mdm2", "is", "a", "master", "negative", "of", "the", "tumor", "suppressor", "p53", "has", "been", "recently", "shown", "to", "regulate", "the", "ubiquitination", "of", "C1412552#ent", "<e1>", "an", "important", "adapter", "and", "scaffold", "in", "signaling", "of", "G-protein-coupled", "receptors", "C3890198#ent", "<e2>", ")", "."], "h": {"id": "C1412552", "name": "C1412552#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3890198", "name": "C3890198#ent", "pos": [32, 33]}}
{"token": ["The", "protein", "conformational", "from", "the", "cellular", "prion", "protein", "C2347435#ent", "<e1>", "to", "PrPSc", "requires", "an", "as", "yet", "unidentified", "species-specific", "C1332924#ent", "<e2>", "named", "\"", "Protein", "X", "."], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332924", "name": "C1332924#ent", "pos": [18, 19]}}
{"token": ["Since", "Rb", "is", "known", "to", "interact", "with", "C1709313#ent", "<e1>", ",", "which", "interrupts", "Rb", "'s", "normal", "function", "we", "examined", "C1332397#ent", "<e2>", ")", "deamidation", "and", "cell", "death", "induced", "by", "cisplatin", "in", "C1709313#ent", "<e1>", "transfectants", "."], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [18, 19]}}
{"token": ["To", "investigate", "the", "changes", "of", "the", "latency", "and", "amplitude", "of", "C1333336#ent", "<e1>", "in", "relation", "to", "C0700545#ent", "<e2>", "(", "MPH", ")", "medication", "."], "h": {"id": "C1333336", "name": "C1333336#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0700545", "name": "C0700545#ent", "pos": [15, 16]}}
{"token": ["However", ",", "translational", "incorporation", "of", "C0019880#ent", "<e1>", "into", "protein", "is", "prevented", "by", "editing", "mechanisms", "of", "these", "C0035685#ent", "<e2>", ",", "which", "convert", "misactivated", "C0019880#ent", "<e1>", "into", "thiolactone", "."], "h": {"id": "C0035685", "name": "C0035685#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [5, 6]}}
{"token": ["As", "a", "complication", "of", "C0011603#ent", "<e1>", "secondary", "lymphoedema", "following", "recurrent", "C0014733#ent", "<e2>", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014733", "name": "C0014733#ent", "pos": [10, 11]}}
{"token": ["C1704715#ent", "<e1>", "may", "be", "the", "most", "suitable", "of", "these", "C0035064#ent", "<e2>", "for", "clinical", "use", "of", "its", "short", "physiological", "half-life", "."], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [9, 10]}}
{"token": ["significantly", "inhibited", "not", "only", "the", "depressor", "responses", "VIP", "and", "C1704715#ent", "<e1>", ",", "but", "also", "the", "augmentation", "of", "the", "effects", "of", "two", "C0035064#ent", "<e2>", "by", "cromakalim", "."], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "where", "the", "superoxide", "generated", "by", "fMet-Leu-Phe", "is", "not", "inhibited", "by", "the", "protein", "kinase", "C", "inhibitor", "1-(5-isoquinolinesulfonyl)-2-methylpiperazine", "C0044222#ent", "<e1>", ")", ",", "the", "increase", "by", "C0072920#ent", "<e2>", "is", "diminished", "by", "this", "compound", "."], "h": {"id": "C0044222", "name": "C0044222#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0072920", "name": "C0072920#ent", "pos": [26, 27]}}
{"token": ["To", "assess", "whether", "adding", "codeine", "to", "C0000970#ent", "<e1>", "has", "an", "additive", "analgesic", "effect", "to", "assess", "the", "safety", "of", "C2351132#ent", "<e2>", "C0000970#ent", "<e1>", "alone", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [6, 7]}, "relation": "part_of", "t": {"id": "C2351132", "name": "C2351132#ent", "pos": [18, 19]}}
{"token": ["The", "results", "suggest", "that", "glucose-6-phosphate", "dehydrogenase", "C0008855#ent", "<e1>", "succinate", "dehydrogenase", "fatty", "acid", "synthase", "stimulated", "by", "higher", "concentration", "of", "ammonium", "ions", "while", "C0033385#ent", "<e2>", "methylmalonyl-CoA", "carboxyltransferase", "inhibited", "."], "h": {"id": "C0008855", "name": "C0008855#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033385", "name": "C0033385#ent", "pos": [21, 22]}}
{"token": ["Neuromuscular", "junctions", "NMJs", ")", "labelled", "with", "C0284749#ent", "<e1>", "were", "colabelled", "with", "calcitonin", "gene-related", "peptide", "C1704715#ent", "<e2>", ")", "or", "4E2", "antisera", "and", "imaged", "using", "confocal", "microscopy"], "h": {"id": "C0284749", "name": "C0284749#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704715", "name": "C1704715#ent", "pos": [14, 15]}}
{"token": ["This", "is", "a", "C1848862#ent", "<e1>", "with", "a", "heterogeneous", "phenotype", "including", "ocular", "signs", "motor", "signs", "and", "C0035204#ent", "<e2>"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [15, 16]}}
{"token": ["As", "with", "other", "patients", "who", "have", "had", "this", "C1848862#ent", "<e1>", ",", "he", "did", "not", "have", "any", "C0035204#ent", "<e2>"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [16, 17]}}
{"token": ["Infants", "weighing", ">", "or", "=", "600", "gm", "with", "C0035220#ent", "<e1>", "required", "assisted", "ventilation", "treated", "within", "8", "hours", "of", "birth", "with", "C0105750#ent", "<e2>", "administered", "intratracheally", "."], "h": {"id": "C0035220", "name": "C0035220#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0105750", "name": "C0105750#ent", "pos": [20, 21]}}
{"token": ["We", "tested", "a", "Saskatchewan", "bison", "isolate", "of", "A.", "marginale", "(", "C1539768#ent", "<e1>", ")", "to", "determine", "whether", "it", "is", "transmissible", "by", "the", "C0035793#ent", "<e2>", "Dermacentor", "andersoni", "Stiles", "."], "h": {"id": "C1539768", "name": "C1539768#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035793", "name": "C0035793#ent", "pos": [21, 22]}}
{"token": ["Acute", "interstitial", "pneumonitis", "C0162565#ent", "<e1>", ")", ",", "also", "known", "as", "C0085786#ent", "<e2>", "is", "a", "distinct", "type", "of", "idiopathic", "interstitial", "pneumonia", "patients", "of", "both", "genders", "without", "pre-existing", "lung", "diseases"], "h": {"id": "C0162565", "name": "C0162565#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085786", "name": "C0085786#ent", "pos": [10, 11]}}
{"token": ["In", "terms", "of", "the", "FEV1", ",", "C1276807#ent", "<e1>", "produced", "an", "effect", "greater", "than", "that", "of", "both", "C0054201#ent", "<e2>", "alone", "and", "formoterol", "alone", "reported", "in", "previous", "studies", "."], "h": {"id": "C1276807", "name": "C1276807#ent", "pos": [6, 7]}, "relation": "has_constitutional_part", "t": {"id": "C0054201", "name": "C0054201#ent", "pos": [16, 17]}}
{"token": ["Because", "of", "their", "potential", "involvement", "in", "other", "C1285162#ent", "<e1>", "we", "have", "examined", "the", "expression", "of", "C0033679#ent", "<e2>", "(", "TGases", ")", "in", "normal", "and", "SIBM", "tissues", "."], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033679", "name": "C0033679#ent", "pos": [15, 16]}}
{"token": ["C0071174#ent", "<e1>", "and", "C0010592#ent", "<e2>", "bind", "noncompetitively", "in", "Pgp-expressing", "cells", ",", "indicating", "that", "C0071174#ent", "<e1>", "interacts", "with", "Pgp", "at", "sites", "that", "are", "distinct", "from", "CSA-binding", "sites", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0071174", "name": "C0071174#ent", "pos": [0, 1]}}
{"token": ["C0071174#ent", "<e1>", "induced", "an", "increase", "in", "cytoplasmic", "[", "Ca(2+)", ",", "which", "was", "reversed", "by", "C0010592#ent", "<e2>", "A.", "Rhod-2", "staining", "showed", "decreased", "mitochondrial", "[", "Ca(2+)", "after", "C0071174#ent", "<e1>", "treatment", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0071174", "name": "C0071174#ent", "pos": [0, 1]}}
{"token": ["These", "patients", "may", "have", "peripheral", "vertigo", "migraines", ",", "C0751495#ent", "<e1>", ",", "dementia", ",", "functional", "disorders", "amyloid", "angiopathy", "or", "C0025517#ent", "<e2>"], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [18, 19]}}
{"token": ["Serum-concentrations", "of", "soluble", "C1706544#ent", "<e1>", "were", "higher", "with", "C3898153#ent", "<e2>", "compared", "with", "chorioamnionitis", "alone", "or", "control", "group"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3898153", "name": "C3898153#ent", "pos": [8, 9]}}
{"token": ["Tonizid", "prevented", "ventricular", "fibrillation", "C0151814#ent", "<e1>", "exhibited", "antihypoxic", ",", "C0007209#ent", "<e2>", ",", "and", "antifibrillation", "properties", "."], "h": {"id": "C0151814", "name": "C0151814#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [9, 10]}}
{"token": ["For", "instance", ",", "a", "point", "mutation", "in", "a", "human", "clock", "gene", "C1416526#ent", "<e1>", ")", "was", "shown", "to", "produce", "the", "rare", "C0751758#ent", "<e2>", "whereas", "a", "functional", "polymorphism", "in", "Per3", "is", "associated", "with", "more", "frequent", "delayed", "sleep", "phase", "syndrome"], "h": {"id": "C1416526", "name": "C1416526#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0751758", "name": "C0751758#ent", "pos": [20, 21]}}
{"token": ["The", "p38", "pathway", "C0387583#ent", "<e1>", "expression", "at", "the", "posttranscriptional", "level", "because", "the", "presence", "of", "C0297666#ent", "<e2>", "results", "in", "the", "destabilization", "of", "IFN-tau-induced", "C0387583#ent", "<e1>", "mRNA", "."], "h": {"id": "C0297666", "name": "C0297666#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [3, 4]}}
{"token": ["C0297666#ent", "<e1>", "also", "inhibited", "the", "expression", "of", "inducible", "nitric", "oxide", "synthase", "iNOS", ")", "and", "C0387583#ent", "<e2>", "(", "COX-2", ")", "in", "the", "treated", "islets", "."], "h": {"id": "C0297666", "name": "C0297666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [14, 15]}}
{"token": ["Platelet-activating", "factor", "C0235480#ent", "<e1>", ")", "and", "the", "interferons", "(", "C1415900#ent", "<e2>", ")", "are", "released", "during", "sepsis", "and", "the", "adult", "respiratory", "distress", "syndrome"], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [9, 10]}}
{"token": ["Inability", "of", "C0235480#ent", "<e1>", "to", "bind", "Cibacron", "Blue-Sepharose", "unlike", "C1415900#ent", "<e2>", ",", "supports", "this", "notion", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [9, 10]}}
{"token": ["We", "report", "a", "patient", "with", "C0001403#ent", "<e1>", "whom", "the", "initial", "overt", "C3887896#ent", "<e2>", "accompanied", "by", "an", "only", "slightly", "enlarged", "right", "adrenal", "gland"], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C3887896", "name": "C3887896#ent", "pos": [11, 12]}}
{"token": ["Distinct", "gender", "differences", "in", "expression", "of", "C1436224#ent", "<e1>", "observed", "for", "liver", ",", "heart", ",", "kidney", "and", "C0018050#ent", "<e2>", ",", "whereas", "GST", "expression", "was", "similar", "in", "brain", "and", "lung", "for", "both", "genders", "."], "h": {"id": "C1436224", "name": "C1436224#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "C1336666#ent", "<e1>", "and", "c-Src-induced", "JNK", "activation", "was", "significantly", "inhibited", "by", "C2713509#ent", "<e2>", "a", "dominant", "negative", "mutant", "of", "Akt", "(", "Akt", "DN", ")", "."], "h": {"id": "C1336666", "name": "C1336666#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [12, 13]}}
{"token": ["The", "occurrence", "of", "C0027707#ent", "<e1>", "patients", "receiving", "C1136254#ent", "<e2>", "frequently", "been", "reported", "in", "adults", "while", "it", "has", "rarely", "been", "described", "in", "children", "."], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [7, 8]}}
{"token": ["In", "conclusion", ",", "C1422000#ent", "<e1>", "not", "only", "regulates", "mTOR", "but", "also", "regulates", "proteolysis", "through", "C1705590#ent", "<e2>", "provides", "a", "link", "among", "acidosis", ",", "insulin", "resistance", "and", "protein", "wasting", "skeletal", "muscle", "cells"], "h": {"id": "C1422000", "name": "C1422000#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [14, 15]}}
{"token": ["Reagents", "known", "to", "induce", "only", "frequency", "fluctuations", "of", "C0068341#ent", "<e1>", "and", "superoxide", "ion", "induced", "both", "frequency", "and", "amplitude", "fluctuations", "in", "C3714757#ent", "<e2>", "neutrophils", "."], "h": {"id": "C0068341", "name": "C0068341#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [20, 21]}}
{"token": ["RNA", "encoding", "C1415222#ent", "<e1>", ",", "but", "not", "C1415208#ent", "<e2>", ",", "was", "expressed", "."], "h": {"id": "C1415222", "name": "C1415222#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415208", "name": "C1415208#ent", "pos": [7, 8]}}
{"token": ["Persistent", "C0497580#ent", "<e1>", "a", "21-year-old", "patient", "with", "diabetes", "mellitus", "treated", "with", "purified", "interferon-alpha", "(", "C1415900#ent", "<e2>", ")", "obtained", "by", "recombinant", "DNA", "technology"], "h": {"id": "C0497580", "name": "C0497580#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [14, 15]}}
{"token": ["Although", "the", "primary", "function", "the", "respective", "C0014442#ent", "<e1>", "to", "generate", "the", "C0028156#ent", "<e2>", "the", "xanthine", "oxidase", "reaction", "markedly", "more", "complex", "than", "that", "of", "ferredoxin-(cytochrome", "c)-NADP+", "oxidoreductase", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028156", "name": "C0028156#ent", "pos": [11, 12]}}
{"token": ["Cataplexy", ",", "C0233773#ent", "<e1>", "and", "sleep", "paralysis", "frequently", "associated", "with", "C1834372#ent", "<e2>", "."], "h": {"id": "C0233773", "name": "C0233773#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C1834372", "name": "C1834372#ent", "pos": [10, 11]}}
{"token": ["Among", "the", "essential", "forms", "of", "cholestasis", "must", "be", "included", "benign", "recurrent", "C0008372#ent", "<e1>", "Summerskill-Walshe", "disease", ",", "Aagenaes", "disease", ",", "progressive", "familial", "intrahepatic", "cholestasis", "C0017925#ent", "<e2>", "and", "forms", "due", "to", "disorders", "of", "the", "peroxisomes", "."], "h": {"id": "C0008372", "name": "C0008372#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017925", "name": "C0017925#ent", "pos": [23, 24]}}
{"token": ["C1524023#ent", "<e1>", "treatment", "also", "markedly", "decreased", "TSH", "receptor", "and", "C1420709#ent", "<e2>", "levels", ",", "two", "other", "markers", "of", "differentiated", "thyrocytes", "."], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [9, 10]}}
{"token": ["The", "dynamics", "was", "analysed", "of", "changes", "of", "arterial", "blood", "pressure", "C0313532#ent", "<e1>", "prekallikrein", "concentrations", "and", "plasma", "renin", "activity", "C3274822#ent", "<e2>", ")", "in", "50", "patients", "with", "arterial", "hypertension", "in", "relation", "to", "the", "type", "of", "blood", "pressure", "response", "captopril", "."], "h": {"id": "C0313532", "name": "C0313532#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [18, 19]}}
{"token": ["Using", "isotope", "technique", "the", "serum", "binding", "amitriptyline", "(", "C2698304#ent", "<e1>", ")", ",", "nortriptyline", "(", "NT", ")", ",", "and", "C0034414#ent", "<e2>", "(", "Q", ")", "was", "measured", "by", "equilibrium", "dialysis", "sera", "containing", "varying", "amounts", "of", "lipoproteins", "."], "h": {"id": "C2698304", "name": "C2698304#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [18, 19]}}
{"token": ["Neuroleptic", "drugs", "antipsychotics", ")", "produce", "numerous", "side", "effects", "include", "serious", "extrapyramidal", "symptoms", "of", "akathisia", ",", "C0013421#ent", "<e1>", ",", "neuroleptic", "malignant", "syndrome", "parkinsonian", "reactions", "such", "as", "postural", "abnormality", "tremor", ",", "C1276035#ent", "<e2>", "or", "bradykinesia", ",", "rigidity", ",", "and", "tardive", "dyskinesia"], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1276035", "name": "C1276035#ent", "pos": [29, 30]}}
{"token": ["Therapeutic", "use", "of", "C0003015#ent", "<e1>", "a", "kallikrein", "inhibitor", "been", "made", "for", "C0009450#ent", "<e2>", "as", "septicemia", "and", "in", "tumor", "pathology", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [11, 12]}}
{"token": ["Cyclin-dependent", "protein", "kinases", "CDKs", ")", "are", "attractive", "targets", "for", "drug", "discovery", "efforts", "have", "led", "to", "the", "identification", "of", "novel", "CDK", "C0003015#ent", "<e1>", "the", "development", "of", "treatments", "for", "cancers", ",", "neurological", "disorders", "and", "C0009450#ent", "<e2>"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [32, 33]}}
{"token": ["These", "findings", "suggest", "that", "C0003015#ent", "<e1>", "be", "a", "valuable", "adjunct", "to", "IL-2", "therapy", "cancer", "and", "C0009450#ent", "<e2>"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [15, 16]}}
{"token": ["This", "case", "suggests", "that", "C0013015#ent", "<e1>", "may", "induce", "C0027849#ent", "<e2>", "that", "patients", "with", "malignant", "hyperthermia", "are", "at", "increased", "risk", "for", "this", "complication", "."], "h": {"id": "C0013015", "name": "C0013015#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027849", "name": "C0027849#ent", "pos": [8, 9]}}
{"token": ["A", "C0033487#ent", "<e1>", "infusion", "(", "10", "mg/kg/h", ")", "and", "a", "C0020352#ent", "<e2>", "infusion", "were", "then", "begun", "."], "h": {"id": "C0033487", "name": "C0033487#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020352", "name": "C0020352#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "the", "absence", "of", "hemodynamic", "effects", "in", "response", "to", "infusion", "of", "C0033487#ent", "<e1>", "and", "remifentanil", "when", "hydroxyethyl", "starch", "C0020352#ent", "<e2>", ")", "130/0.4", "was", "also", "administered", "."], "h": {"id": "C0033487", "name": "C0033487#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020352", "name": "C0020352#ent", "pos": [19, 20]}}
{"token": ["To", "the", "knowledge", "of", "this", "author", ",", "this", "is", "the", "first", "report", "of", "the", "use", "of", "the", "C0020197#ent", "<e1>", "an", "adjunct", "to", "FNA", "in", "the", "treatment", "of", "C1258666#ent", "<e2>", "the", "hand", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [27, 28]}}
{"token": ["Transplantation", "of", "retinal", "pigment", "epithelium", "may", "be", "a", "treatment", "for", "C0035309#ent", "<e1>", "such", "as", "C0242383#ent", "<e2>", "hereditary", "macular", "degeneration"], "h": {"id": "C0035309", "name": "C0035309#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [14, 15]}}
{"token": ["Although", "the", "roles", "of", "hAG-2", "and", "C3539652#ent", "<e1>", "in", "mammalian", "cells", "unknown", ",", "both", "C0086376#ent", "<e2>", "share", "a", "high", "degree", "of", "protein", "sequence", "homology", "and", "lie", "adjacent", "to", "one", "another", "on", "chromosome", "7p21"], "h": {"id": "C3539652", "name": "C3539652#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}}
{"token": ["DNA", "and", "protein", "analysis", "that", "C3539652#ent", "<e1>", "has", "no", "homology", "to", "any", "known", "cDNAs", "or", "C0086376#ent", "<e2>", "."], "h": {"id": "C3539652", "name": "C3539652#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["NADPH", "is", "mainly", "produced", "by", "glucose", "6-phosphate", "dehydrogenase", "G6PDH", ";", "EC", "1.1.1.49", "and", "6-phosphogluconate", "dehydrogenase", "6PGDH", ";", "C4283949#ent", "<e1>", "from", "the", "oxidative", "pentose", "phosphate", "pathway", "and", "also", "by", "C1417092#ent", "<e2>", "ICDH", ";", "EC", "1.1.1.42", "."], "h": {"id": "C4283949", "name": "C4283949#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417092", "name": "C1417092#ent", "pos": [28, 29]}}
{"token": ["Slow", "coronary", "flow", "C1366480#ent", "<e1>", ")", "has", "long", "been", "identified", "and", "endothelial", "dysfunction", "C0004153#ent", "<e2>", "of", "epicardial", "coronary", "arteries", "microvasculature", "were", "reported", "to", "be", "associated", "with", "C1366480#ent", "<e1>", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [13, 14]}}
{"token": ["Increased", "IMT", "in", "patients", "with", "C1366480#ent", "<e1>", "shows", "that", "C0004153#ent", "<e2>", "play", "role", "in", "this", "phenomenon", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [9, 10]}}
{"token": ["Slow", "coronary", "flow", "C1366480#ent", "<e1>", ")", "has", "long", "since", "been", "identified", "and", "endothelial", "dysfunction", "C0004153#ent", "<e2>", "of", "the", "epicardial", "coronary", "arteries", "microvasculature", "are", "reported", "to", "be", "associated", "with", "C1366480#ent", "<e1>", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [14, 15]}}
{"token": ["In", "a", "prospective", "study", "C0022143#ent", "<e1>", "abnormal", "in", "56", "%", "of", "41", "patients", "with", "C0008312#ent", "<e2>", "36", "%", "of", "22", "patients", "with", "primary", "sclerosing", "cholangitis", "NS", ")", ",", "indicating", "pancreatic", "damage", "in", "both", "diseases", "."], "h": {"id": "C0022143", "name": "C0022143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [14, 15]}}
{"token": ["In", "two", "patients", "the", "onset", "of", "C0021847#ent", "<e1>", "occurred", "before", "the", "C1865926#ent", "<e2>", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1865926", "name": "C1865926#ent", "pos": [11, 12]}}
{"token": ["C1422337#ent", "<e1>", "was", "neither", "an", "C0007641#ent", "<e2>", ",", "a", "cellobiohydrolase", "able", "to", "hydrolyze", "fluorogenic", "cellobiosides", ",", "a", "beta-glucosidase", ",", "a", "xylanase", ",", "nor", "a", "cellobiose", ":", "quinone", "oxidoreductase"], "h": {"id": "C1422337", "name": "C1422337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007641", "name": "C0007641#ent", "pos": [5, 6]}}
{"token": ["The", "transition", "regions", "other", "disease-related", "genes", "including", "APP", "associated", "with", "familial", "Alzheimer's", "disease", "AD1", ")", ",", "SOD1", "associated", "with", "C0002736#ent", "<e1>", "ALS1", ")", "and", "PTS", "associated", "with", "C0031485#ent", "<e2>", "."], "h": {"id": "C0002736", "name": "C0002736#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [27, 28]}}
{"token": ["We", "found", "distinct", "expression", "profiles", "C1430988#ent", "<e1>", "DLBCL", "subtypes", "and", "identified", "putative", "STAT6", "tyrosine", "phosphatases-protein", "tyrosine", "phosphatase", "nonreceptor", "type", "1", "C1335056#ent", "<e2>", ")", "and", "PTPN2", ",", "whose", "expression", "is", "significantly", "higher", "in", "ABC-like", "DLBCL", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335056", "name": "C1335056#ent", "pos": [20, 21]}}
{"token": ["Because", "signaling", "by", "NK", "inhibitory", "receptors", "be", "involved", "in", "this", "process", ",", "the", "human", "NK", "tumor", "line", "C1337037#ent", "<e1>", "was", "transfected", "with", "signal-competent", "and", "signal-incompetent", "C1416643#ent", "<e2>", "."], "h": {"id": "C1337037", "name": "C1337037#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416643", "name": "C1416643#ent", "pos": [25, 26]}}
{"token": ["To", "study", "the", "efficacy", "of", "prophylactic", "C0023660#ent", "<e1>", "treatment", "on", "the", "C2984892#ent", "<e2>", "of", "ventricular", "tachyarrhythmias", "recanalization", "of", "an", "occluded", "coronary", "artery", "49", "patients", "with", "an", "acute", "myocardial", "infarction", "studied", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2984892", "name": "C2984892#ent", "pos": [11, 12]}}
{"token": ["After", "C0030779#ent", "<e1>", "activation", "of", "C0023524#ent", "<e2>", ",", "the", "expression", "of", "E2F1", "and", "DNA-PK", "activity", "increased", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [5, 6]}}
{"token": ["Specific", "manifestations", "can", "include", "patches", "(", "sometimes", "hypopigmented", ")", ",", "papules", ",", "scar", "sarcoidosis", "C0149745#ent", "<e1>", ",", "ichthyosis", ",", "and", "C0002170#ent", "<e2>", "."], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [20, 21]}}
{"token": ["We", "have", "shown", "that", "C3884445#ent", "<e1>", "interacts", "with", "the", "IL-5", "receptor-associated", "tyrosine", "kinases", "C1442804#ent", "<e2>", "and", "JAK2", ",", "in", "eosinophils", "."], "h": {"id": "C3884445", "name": "C3884445#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [13, 14]}}
{"token": ["We", "examined", "the", "expression", "of", "p130", "and", "C1419295#ent", "<e1>", "in", "stimulated", "3T3-L1", "cells", "the", "presence", "of", "either", "PD98059", ",", "C0755562#ent", "<e2>", "or", "sodium", "vanadate"], "h": {"id": "C1419295", "name": "C1419295#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "demonstrate", "that", "C1822783#ent", "<e1>", "also", "contribute", "to", "the", "control", "of", "C0030499#ent", "<e2>", "Leishmania", "major"], "h": {"id": "C1822783", "name": "C1822783#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [12, 13]}}
{"token": ["The", "increase", "in", "hydroxylysine", "concentration", "and", "ratio", "to", "hydroxyproline", "indicate", "that", "patients", "with", "localized", "C1290049#ent", "<e1>", "an", "increased", "proportion", "of", "newly", "synthesized", "C0009325#ent", "<e2>", "in", "the", "fibrotic", "plaque"], "h": {"id": "C1290049", "name": "C1290049#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [22, 23]}}
{"token": ["The", "C0086376#ent", "<e1>", "recognized", "by", "mAb", "C3890000#ent", "<e2>", "and", "SM62", "were", "easily", "detectable", "by", "immunoblotting", "and", "immunostaining", "in", "Sf9", "cells", "infected", "with", "recombinant", "BV", "rBV", ")", ",", "but", "not", "in", "non-infected", "cells", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3890000", "name": "C3890000#ent", "pos": [6, 7]}}
{"token": ["Our", "data", "have", "shown", "that", "transgelin", "and", "several", "other", "C0086376#ent", "<e1>", "of", "unknown", "function", ",", "C3890000#ent", "<e2>", "Pearlstone", "et", "al.", ",", "1987", ":", "J.", "Biol", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3890000", "name": "C3890000#ent", "pos": [15, 16]}}
{"token": ["The", "C0040517#ent", "<e1>", "symptoms", "remitted", "after", "treatment", "with", "C0062103#ent", "<e2>"], "h": {"id": "C0040517", "name": "C0040517#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0062103", "name": "C0062103#ent", "pos": [8, 9]}}
{"token": ["C3889130#ent", "<e1>", ",", "which", "is", "expressed", "constitutively", "on", "B", "cells", "binds", "the", "C1415846#ent", "<e2>", "ICOS", ")", "on", "antigen-activated", "T", "cells", ",", "is", "a", "member", "of", "the", "B7", "family", "of", "costimulatory", "ligands", "."], "h": {"id": "C3889130", "name": "C3889130#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415846", "name": "C1415846#ent", "pos": [12, 13]}}
{"token": ["Blockade", "of", "ICOS-mediated", "costimulation", "by", "administration", "of", "anti-ICOS", "ligand", "(", "C3889130#ent", "<e1>", ")", "mAb", "or", "by", "C1415846#ent", "<e2>", "knockout", "substantially", "inhibited", "alpha-GalCer-induced", "IFN-gamma", "and", "IL-4", "production", ",", "cytotoxic", "activity", "and", "anti-metastatic", "effect", "."], "h": {"id": "C3889130", "name": "C3889130#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415846", "name": "C1415846#ent", "pos": [16, 17]}}
{"token": ["C1705516#ent", "<e1>", "but", "not", "ROS-2", "was", "an", "effective", "inhibitor", "of", "C1849508#ent", "<e2>", "activity", ",", "suggesting", "that", "C1705516#ent", "<e1>", "may", "be", "a", "specific", "probe", "to", "study", "the", "effects", "of", "ROS", "C1849508#ent", "<e2>", "on", "the", "light", "response"], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1849508", "name": "C1849508#ent", "pos": [10, 11]}}
{"token": ["Interruption", "of", "this", "intracellular", "communication", "mechanism", "may", "be", "etiologically", "linked", "to", "the", "the", "distal", "axon", "degeneration", "follows", "repetitive", "exposure", "to", "vinca", "alkaloids", "other", "C0991617#ent", "<e1>", "that", "induce", "C0270934#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0270934", "name": "C0270934#ent", "pos": [27, 28]}}
{"token": ["PGE2", "and", "some", "C0033568#ent", "<e1>", "11-deoxy-derivatives", ")", ",", "which", "stimulate", "C0038317#ent", "<e2>", "output", "in", "vitro", "enhanced", "the", "effect", "of", "caffeine", "."], "h": {"id": "C0033568", "name": "C0033568#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [10, 11]}}
{"token": ["Eight", "patients", "were", "being", "treated", "with", "beta-blocking", "agents", "eight", "with", "C0006684#ent", "<e1>", "four", "with", "angiotensin-converting", "enzyme", "inhibitors", "four", "with", "diuretics", "and", "one", "with", "C0032912#ent", "<e2>", "in", "combination", "therapy"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [23, 24]}}
{"token": ["A", "48-year-old", "man", "with", "severe", "variant", "angina", "refractory", "to", "conventional", "treatment", "C0006684#ent", "<e1>", "nitrates", ",", "or", "C0032912#ent", "<e2>", ",", "or", "trihexyphenidyl", "hydrochloride", "became", "symptom", "free", "rapidly", "when", "treated", "with", "denopamine", ",", "a", "adrenergic", "beta-1", "agonist"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "angiotensin-converting", "enzyme", "inhibitors", "C0006684#ent", "<e1>", "and", "peripheral", "alpha-blockers", "such", "as", "C0032912#ent", "<e2>", "and", "terazosin", ")", "do", "not", "adversely", "affect", "glucose", "tolerance", "insulin", "sensitivity"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [13, 14]}}
{"token": ["Type", "IV", "the", "C0349653#ent", "<e1>", "glycoprotein", "syndromes", "CDGS", ")", "is", "characterized", "by", "microcephaly", ",", "severe", "C0014547#ent", "<e2>", ",", "minimal", "psychomotor", "development", "partial", "deficiency", "sialic", "acids", "serum", "glycoproteins"], "h": {"id": "C0349653", "name": "C0349653#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [15, 16]}}
{"token": ["To", "highlight", "this", "underdiagnosed", "C0747256#ent", "<e1>", "we", "describe", "a", "case", "series", "patients", "with", "C0018013#ent", "<e2>", "who", "were", "treated", "during", "a", "12-month", "period", "at", "the", "Hospital", "for", "Tropical", "Diseases", "London", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0018013", "name": "C0018013#ent", "pos": [13, 14]}}
{"token": ["Consistently", ",", "deletion", "of", "the", "Mnk-specific", "insertion", "or", "removal", "of", "a", "conserved", "phenylalanine", "side", "chain", "which", "induces", "a", "blockade", "of", "the", "ATP", "pocket", ",", "increase", "the", "C1705556#ent", "<e1>", "affinity", "of", "C0539636#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0539636", "name": "C0539636#ent", "pos": [30, 31]}}
{"token": ["Therefore", "the", "present", "results", "confirm", "that", "in", "the", "geographical", "area", "which", "these", "tumors", "proceed", ",", "C0031669#ent", "<e1>", "is", "closely", "correlated", "with", "HBsAg", "positivity", "and", "with", "C1623038#ent", "<e2>", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [25, 26]}}
{"token": ["In", "32", "cases", "C0031669#ent", "<e1>", "was", "confirmed", "within", "a", "year", "of", "diagnosis", "of", "C1623038#ent", "<e2>", ",", "while", "in", "the", "remaining", "41", "cases", "C0031669#ent", "<e1>", "developed", "2", "to", "13", "years", "later", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [13, 14]}}
{"token": ["In", "this", "new", "schema", ",", "Class", "I", "local", "anesthetics", "is", "subdivided", "into", "1A", "(", "quinidine-like", "agents", "with", "cholinergic", "blocking", "actions", ")", "and", "1B", "(", "C0991617#ent", "<e1>", "such", "as", "C0360097#ent", "<e2>", "without", "autonomic", "activity", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0360097", "name": "C0360097#ent", "pos": [28, 29]}}
{"token": ["Action", "potential", "amplitude", "and", "maximal", "rate", "of", "depolarization", "(", "Vmax", ")", "were", "significantly", "decreased", "by", "all", "C0991617#ent", "<e1>", "in", "the", "following", "order", ":", "bupivacaine", ",", "ropivacaine", ",", "C0360097#ent", "<e2>", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0360097", "name": "C0360097#ent", "pos": [27, 28]}}
{"token": ["In", "addition", ",", "APC", "remained", "bound", "to", "C0796074#ent", "<e1>", "stabilized", "with", "low", "C0028247#ent", "<e2>", ",", "whereas", "EB1", "did", "not", "."], "h": {"id": "C0796074", "name": "C0796074#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028247", "name": "C0028247#ent", "pos": [12, 13]}}
{"token": ["That", "cell-cell", "contact", "also", "specifies", "the", "type", "of", "Glu", "C0796074#ent", "<e1>", "formed", "in", "cells", "was", "shown", "by", "experiments", "in", "which", "C0796074#ent", "<e1>", "were", "regrown", "following", "complete", "depolymerization", "with", "C0028247#ent", "<e1>", "."], "h": {"id": "C0796074", "name": "C0796074#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028247", "name": "C0028247#ent", "pos": [28, 29]}}
{"token": ["Here", ",", "we", "investigated", "the", "direct", "role", "of", "transforming", "growth", "factor", "beta-1", "altering", "the", "transformed", "phenotype", "and", "regulating", "the", "actin", "organisation", "oncogenic", "fibroblasts", "that", "C0669365#ent", "<e1>", "or", "inducibly", "express", "the", "C0018446#ent", "<e2>"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0018446", "name": "C0018446#ent", "pos": [30, 31]}}
{"token": ["Since", "IL-6", "and", "GM-CSF", "play", "an", "important", "role", "in", "maintaining", "basal", "hemopoiesis", "our", "results", "suggest", "that", "an", "abnormal", "C1333196#ent", "<e1>", "network", "may", "be", "involved", "in", "the", "pathogenesis", "of", "C0030312#ent", "<e2>"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [28, 29]}}
{"token": ["Hemophagocytosis", "from", "macrophage", "activation", "during", "a", "C1333196#ent", "<e1>", "result", "in", "C0030312#ent", "<e2>", "and", "disseminated", "intravascular", "coagulopathy"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [10, 11]}}
{"token": ["Indomethacin", ",", "a", "C0085387#ent", "<e1>", "inhibited", "staurosporine-caused", "C1704862#ent", "<e2>", "induction", ",", "but", "not", "TPA-caused", "C1704862#ent", "<e2>", "induction", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704862", "name": "C1704862#ent", "pos": [7, 8]}}
{"token": ["On", "the", "other", "hand", ",", "indomethacin", ",", "a", "selective", "C0085387#ent", "<e1>", "enhanced", "the", "TPA-induced", "increase", "in", "C1704862#ent", "<e2>", "activity", "in", "these", "tissues", "dose-dependently", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704862", "name": "C1704862#ent", "pos": [16, 17]}}
{"token": ["Both", "C0029896#ent", "<e1>", "present", "with", "C0392171#ent", "<e2>", "may", "be", "complicated", "by", "thrombotic", "microangiopathy", "hemorrhagic", "phenomena", "and", "hepatic", "and", "pulmonary", "involvement", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0392171", "name": "C0392171#ent", "pos": [5, 6]}}
{"token": ["The", "same", "holds", "true", "for", "C1824668#ent", "<e1>", ",", "with", "the", "exception", "of", "patients", "with", "C0027697#ent", "<e2>", "in", "which", "the", "highest", "levels", "were", "observed", "."], "h": {"id": "C1824668", "name": "C1824668#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027697", "name": "C0027697#ent", "pos": [14, 15]}}
{"token": ["Various", "strategies", "have", "been", "used", ",", "including", "the", "use", "of", "enzyme", "inhibitors", "either", "C0003805#ent", "<e1>", "(", "AROM", ")", "or", "C0052456#ent", "<e2>", "STS", ")", ",", "in", "an", "attempt", "to", "ablate", "E2", "levels", "."], "h": {"id": "C0003805", "name": "C0003805#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0052456", "name": "C0052456#ent", "pos": [19, 20]}}
{"token": ["Ten", "minutes", "of", "C0917798#ent", "<e1>", "not", "modify", "the", "interaction", "between", "C0205812#ent", "<e2>", "and", "KYNA", "."], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [10, 11]}}
{"token": ["This", "paper", "describes", "a", "sensitive", "and", "specific", "immunoblotting", "procedure", "detect", "C1722829#ent", "<e1>", "La(SS-B", ")", "autoantibodies", "in", "the", "serum", "of", "patients", "with", "C0409974#ent", "<e2>"], "h": {"id": "C1722829", "name": "C1722829#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0409974", "name": "C0409974#ent", "pos": [21, 22]}}
{"token": ["C0040779#ent", "<e1>", "suppresses", "platelet-derived", "growth", "factor", "vascular", "smooth", "muscle", "cell", "VSMC", ")", "proliferation", "by", "inhibiting", "Raf-1/extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e2>", ")", "via", "cAMP/protein", "kinase", "A", "(", "PKA", ")", "."], "h": {"id": "C0040779", "name": "C0040779#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [18, 19]}}
{"token": ["This", "is", "also", "the", "case", "for", "other", "movement", "disorders", "action", "myoclonus", "epilepsy-as", "described", "in", "C0017409#ent", "<e1>", "30", ")", ",", "now", "better", "referred", "to", "as", "C0751785#ent", "<e2>", "40", ")", "(", "Fig.", "14", ")", "."], "h": {"id": "C0017409", "name": "C0017409#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751785", "name": "C0751785#ent", "pos": [24, 25]}}
{"token": ["This", "low", "diagnostic", "yield", "probably", "reflects", "differences", "in", "ascertainment", "of", "patients", ";", "those", "described", "here", "were", "referred", "with", "a", "syndrome", "of", "progressive", "myoclonic", "ataxia", "the", "C0017409#ent", "<e1>", "rather", "than", "progressive", "C0751785#ent", "<e2>"], "h": {"id": "C0017409", "name": "C0017409#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0751785", "name": "C0751785#ent", "pos": [30, 31]}}
{"token": ["The", "comparison", "of", "x-ray", "structures", "C0022575#ent", "<e1>", "and", "MthK", "shows", "that", "channel", "activation", "C2712370#ent", "<e2>", "backbone", "torsions", "helical", "H-bonds", "in", "residues", "95", "-", "105", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [13, 14]}}
{"token": ["E150", "K", "opsin", "expressed", "in", "HEK293", "cells", "reconstituted", "with", "11-cis-retinal", "displayed", "an", "absorption", "spectrum", "to", "the", "wild", "type", "WT", ")", "counterpart", "and", "activated", "C0040663#ent", "<e1>", "faster", "than", "C1706234#ent", "<e2>"], "h": {"id": "C0040663", "name": "C0040663#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1706234", "name": "C1706234#ent", "pos": [27, 28]}}
{"token": ["We", "consider", "that", "human", "parvovirus", "infection", "and", "unknown", "C1387532#ent", "<e1>", "must", "be", "systematically", "researched", "in", "any", "case", "of", "unexplained", "C0002874#ent", "<e2>"], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [19, 20]}}
{"token": ["However", ",", "neither", "GLUT1", "nor", "C3889450#ent", "<e1>", "were", "affected", "by", "treatments", "with", "hCG", ",", "C1334089#ent", "<e2>", "or", "hCG", "and", "C1334089#ent", "<e2>", "combined", "."], "h": {"id": "C3889450", "name": "C3889450#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "of", "the", "cultured", "hepatocytes", "with", "C0043167#ent", "<e1>", "blocked", "the", "effects", "of", "PGE2", "and", "C0000139#ent", "<e2>", "PGE2", "completely", "and", "concentration-dependently", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0000139", "name": "C0000139#ent", "pos": [14, 15]}}
{"token": ["Intrathecal", "administration", "the", "Src-family", "tyrosine", "kinase", "inhibitor", "4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine", "(", "C1417819#ent", "<e1>", ")", "suppressed", "nerve", "injury-induced", "mechanical", "hypersensitivity", "not", "heat", "and", "C3489856#ent", "<e2>"], "h": {"id": "C1417819", "name": "C1417819#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3489856", "name": "C3489856#ent", "pos": [20, 21]}}
{"token": ["C0043541#ent", "<e1>", "a", "rare", "C0011630#ent", "<e2>", "mainly", "from", "the", "United", "States", "of", "America", "Europe", "."], "h": {"id": "C0043541", "name": "C0043541#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011630", "name": "C0011630#ent", "pos": [4, 5]}}
{"token": ["This", "review", "focuses", "on", "C1421249#ent", "<e1>", "have", "been", "implicated", "in", "the", "pathogenesis", "of", "C0018939#ent", "<e2>", "than", "chronic", "myelogenous", "leukemia", "discusses", "the", "evidence", "for", "the", "use", "of", "small", "molecules", "target", "these", "kinases", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [13, 14]}}
{"token": ["Since", "C0045686#ent", "<e1>", "does", "not", "share", "significant", "homology", "with", "other", "C0033607#ent", "<e2>", "our", "results", "define", "it", "as", "the", "prototype", "of", "a", "novel", "class", "of", "C0033607#ent", "<e2>"], "h": {"id": "C0045686", "name": "C0045686#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [10, 11]}}
{"token": ["Our", "studies", "indicate", "that", "Kell", "and", "C1706431#ent", "<e1>", "use", "the", "same", "homologous", "amino", "acids", "the", "coordination", "of", "C3541396#ent", "<e2>", "and", "in", "peptide", "hydrolysis", "."], "h": {"id": "C1706431", "name": "C1706431#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541396", "name": "C3541396#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "suggest", "that", "oestrogen", ",", "but", "not", "C2757070#ent", "<e1>", ",", "may", "be", "the", "critical", "factor", "to", "explain", "the", "C0008043#ent", "<e2>", "down-regulation", "of", "CIA", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008043", "name": "C0008043#ent", "pos": [19, 20]}}
{"token": ["Using", "the", "nontumorigenic", "C1720862#ent", "<e1>", "and", "tumorigenic", "CGL3", ",", "forward", "(", "C1707074#ent", "<e2>", ")", "and", "reverse", "(", "CGL3-CGL1", ")", "subtracted", "libraries", "were", "constructed", "."], "h": {"id": "C1720862", "name": "C1720862#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1707074", "name": "C1707074#ent", "pos": [11, 12]}}
{"token": ["Interestingly", ",", "protein", "expression", "C0026900#ent", "<e1>", "is", "increased", "after", "catechol", "exposure", "in", "C1706481#ent", "<e2>", "deficient", "cells", "while", "decreased", "in", "wild-type", "cells", "."], "h": {"id": "C0026900", "name": "C0026900#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706481", "name": "C1706481#ent", "pos": [12, 13]}}
{"token": ["Although", "not", "reaching", "statistical", "significance", "C0009026#ent", "<e1>", "showed", "anti-manic", "effects", ",", "while", "C0009026#ent", "<e1>", "remained", "ineffective", "."], "h": {"id": "C0009026", "name": "C0009026#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009026", "name": "C0009026#ent", "pos": [5, 6]}}
{"token": ["In", "a", "double-blind", "pilot", "study", "10", "manic", "patients", ",", "C0009026#ent", "<e1>", "was", "compared", "with", "C0009026#ent", "<e1>", "."], "h": {"id": "C0009026", "name": "C0009026#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009026", "name": "C0009026#ent", "pos": [9, 10]}}
{"token": ["However", ",", "C0009026#ent", "<e1>", "possesses", "anti-dopaminergic", "effects", ",", "while", "C0009026#ent", "<e1>", "does", "not", "."], "h": {"id": "C0009026", "name": "C0009026#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009026", "name": "C0009026#ent", "pos": [2, 3]}}
{"token": ["Ileocolonoscopy", "with", "biopsy", "of", "the", "ileum", ",", "ileocecal", "valve", "cecum", "was", "performed", "on", "32", "patients", "(", "22", "males", ",", "10", "females", ")", "with", "C3714757#ent", "<e1>", "JCA", ")", "with", "C0157917#ent", "<e2>"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [23, 24]}, "relation": "nichd_parent_of", "t": {"id": "C0157917", "name": "C0157917#ent", "pos": [28, 29]}}
{"token": ["Computer-assisted", "searching", "putative", "binding", "sites", "for", "activator", "protein", "AP", ")", "2", "and", "specificity", "protein", "SP", ")", "1", "transcription", "factors", "plus", "a", "CACCC", "box", "in", "C1540007#ent", "<e1>", "and", "an", "AP1", "site", "C2347280#ent", "<e2>", "."], "h": {"id": "C1540007", "name": "C1540007#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C2347280", "name": "C2347280#ent", "pos": [30, 31]}}
{"token": ["These", "symptoms", "are", "extremely", "variable", ",", "ranging", "from", "irritability", ",", "C0235014#ent", "<e1>", "and", "neck", "stiffness", "to", "convulsions", ",", "cranial", "nerve", "palsies", "ataxia", ",", "C0018991#ent", "<e2>", ",", "and", "unconsciousness", "."], "h": {"id": "C0235014", "name": "C0235014#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018991", "name": "C0018991#ent", "pos": [23, 24]}}
{"token": ["Because", "C0010072#ent", "<e1>", "a", "hallmark", "of", "C0001363#ent", "<e2>", "the", "substrates", "of", "the", "coagulation", "and", "fibrinolysis", "cascades", "be", "markers", "of", "coronary", "ischemia"], "h": {"id": "C0010072", "name": "C0010072#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001363", "name": "C0001363#ent", "pos": [6, 7]}}
{"token": ["These", "results", "provide", "the", "first", "demonstration", "that", "WT1", "can", "directly", "modulate", "the", "expression", "of", "a", "C0079429#ent", "<e1>", "involved", "in", "C1539078#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "the", "absence", "of", "mismatch", "repair", "alters", "the", "molecular", "mechanisms", "in", "transformation", "by", "affecting", "a", "C0079429#ent", "<e1>", "that", "controls", "apoptosis", "and", "C1539078#ent", "<e2>", "rather", "than", "by", "affecting", "these", "processes", "directly", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [22, 23]}}
{"token": ["The", "properties", "of", "these", "mutants", "were", "assessed", "by", "kinetic", "analysis", "enzyme", "I", "enzyme", "IImannose", ",", "enzyme", "C0001056#ent", "<e1>", ",", "and", "enzyme", "IImannitol", ",", "and", "the", "C0001109#ent", "<e2>", "properties", "of", "the", "HPr", "mutants"], "h": {"id": "C0001056", "name": "C0001056#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001109", "name": "C0001109#ent", "pos": [25, 26]}}
{"token": ["A", "clinical", "association", "been", "reported", "between", "C1961835#ent", "<e1>", "which", "is", "caused", "by", "a", "C1961835#ent", "<e1>", "to", "mutations", "in", "the", "glucocerebrosidase", "gene", "GBA", ")", ",", "and", "parkinsonism", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [6, 7]}}
{"token": ["Sequencing", "of", "RT-PCR", "cDNAs", "from", "five", "unrelated", "Korean", "and", "two", "sibling", "Chinese", "(", "Taiwanese", ")", "C1961835#ent", "<e1>", "patients", "identified", "three", "new", "C1961835#ent", "<e1>", "mutations", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [15, 16]}}
{"token": ["The", "main", "objective", "of", "this", "study", "was", "to", "provide", "scientific", "arguments", "whether", "a", "distinction", "between", "type", "I", "C1961835#ent", "<e1>", ")", "and", "types", "II", "III", "(", "neuronopathic", ")", "C1961835#ent", "<e1>", "be", "maintained", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [17, 18]}}
{"token": ["However", ",", "acetylcholine", "release", "was", "operative", "in", "a", "To/9", "clone", "which", "was", "co-transfected", "with", "complementary", "C0011519#ent", "<e1>", "from", "rat", "C4082365#ent", "<e2>", "Torpedo", "mediatophore", "mol", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4082365", "name": "C4082365#ent", "pos": [19, 20]}}
{"token": ["Triton", "X-100", "slightly", "changed", "C0014442#ent", "<e1>", "sensitivity", "towards", "clorgyline", "and", "C0086130#ent", "<e2>", ",", "regardless", "of", "the", "preincubation", "time", "or", "the", "substrate", "used", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086130", "name": "C0086130#ent", "pos": [10, 11]}}
{"token": ["This", "C0014442#ent", "<e1>", "form", "is", "selectively", "inactivated", "by", "the", "monoamine", "oxidase", "type", "B", "inhibitor", "C0086130#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086130", "name": "C0086130#ent", "pos": [14, 15]}}
{"token": ["GLUT4", "translocation", "requires", "activation", "of", "two", "distinct", "pathways", "involving", "C0044602#ent", "<e1>", "PI", "3-K", ")", "and", "the", "small", "GTP-binding", "protein", "C1425056#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425056", "name": "C1425056#ent", "pos": [19, 20]}}
{"token": ["Despite", "trials", "with", "steroids", ",", "C0008163#ent", "<e1>", ",", "azathioprine", ",", "and", "cyclosporine", ",", "C2316810#ent", "<e2>", "by", "the", "age", "of", "9", "years", "."], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [13, 14]}}
{"token": ["Competition", "studies", "suggest", "that", "the", "CCAAT", "factor", "binds", "to", "this", "promoter", "is", "homologous", "to", "C0527520#ent", "<e1>", "which", "binds", "to", "the", "major", "C0024518#ent", "<e2>", "."], "h": {"id": "C0527520", "name": "C0527520#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [21, 22]}}
{"token": ["We", "describe", "five", "patients", "with", "plasma", "cell", "dyscrasias", "renal", "insufficiency", "C0268381#ent", "<e1>", "monoclonal", "gammopathy", "undetermined", "significance", "with", "Fanconi", "syndrome", "and", "multiple", "myeloma", "treated", "with", "C1144149#ent", "<e2>", "and", "dexamethasone", "who", "developed", "progressive", "azotemia", "."], "h": {"id": "C0268381", "name": "C0268381#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1144149", "name": "C1144149#ent", "pos": [24, 25]}}
{"token": ["C0085154#ent", "<e1>", ",", "a", "new", "H2-receptor", "antagonist", "for", "the", "treatment", "of", "C0013295#ent", "<e2>", "was", "compared", "with", "placebo", "in", "a", "dose-response", ",", "double-blind", ",", "parallel", ",", "multicenter", "clinical", "trial"], "h": {"id": "C0085154", "name": "C0085154#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [11, 12]}}
{"token": ["C0085154#ent", "<e1>", ",", "a", "new", "H2-receptor", "antagonist", "for", "the", "treatment", "of", "C0013295#ent", "<e2>", "was", "compared", "with", "cimetidine", "in", "an", "8-wk", ",", "randomized", ",", "double-blind", ",", "multicenter", "clinical", "trial"], "h": {"id": "C0085154", "name": "C0085154#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [11, 12]}}
{"token": ["C0085154#ent", "<e1>", ",", "a", "new", "H2-receptor", "antagonist", "for", "treatment", "of", "C0013295#ent", "<e2>", "was", "evaluated", "in", "a", "unique", "two-phase", ",", "placebo-controlled", ",", "randomized", ",", "double-blind", ",", "multicenter", "clinical", "trial"], "h": {"id": "C0085154", "name": "C0085154#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", "to", "HO-1", ",", "C1428880#ent", "<e1>", "gene", "expression", "markedly", "down-regulated", "in", "C1704942#ent", "<e2>", "patients", "compared", "with", "controls", "."], "h": {"id": "C1428880", "name": "C1428880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [12, 13]}}
{"token": ["Removal", "of", "C3539739#ent", "<e1>", "by", "green", "alga", "Chlorella", "fusca", "was", "characterized", ",", "because", "we", "previously", "found", "that", "various", "C0031428#ent", "<e2>", "were", "well", "removed", "by", "this", "strain", ",", "including", "C3539739#ent", "<e1>", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3539739", "name": "C3539739#ent", "pos": [2, 3]}}
{"token": ["In", "a", "cross-sectional", "postal", "survey", "we", "compared", "patient-reported", "outcomes", "patients", "undergoing", "breast", "reconstruction", "the", "deep", "inferior", "epigastric", "perforator", "DIEP", ")", "C1412362#ent", "<e1>", "or", "an", "expandable", "breast", "implant", "(", "C1420599#ent", "<e2>", ")", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1420599", "name": "C1420599#ent", "pos": [28, 29]}}
{"token": ["The", "decreases", "in", "CBF", "and", "RBF", ",", "and", "increases", "in", "MBP", "and", "C1417822#ent", "<e1>", "were", "blunted", "by", "C0288663#ent", "<e2>", ",", "an", "ET(A)", "receptor", "antagonist", "BQ-788", ",", "an", "ET(B", ")", "receptor", "antagonist", "."], "h": {"id": "C1417822", "name": "C1417822#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0288663", "name": "C0288663#ent", "pos": [17, 18]}}
{"token": ["We", "found", "that", "NAC", "and", "C1418193#ent", "<e1>", "prevent", "degradation", "of", "C1567710#ent", "<e2>", "during", "auto-oxidized", "dopamine-", "or", "auto-oxidized", "L-DOPA-induced", "apoptosis", "in", "PC12", "cells"], "h": {"id": "C1418193", "name": "C1418193#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1567710", "name": "C1567710#ent", "pos": [10, 11]}}
{"token": ["This", "study", "aimed", "to", "assess", "concomitantly", "the", "effects", "of", "fenofibrate", "therapy", "C0255161#ent", "<e1>", "inhibitor", "concentrations", "and", "endothelial", "functions", "patients", "with", "C0524620#ent", "<e2>"], "h": {"id": "C0255161", "name": "C0255161#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [20, 21]}}
{"token": ["The", "intracellular", "pH", "(", "C1704947#ent", "<e1>", ")", "of", "squid", "C0017547#ent", "<e2>", "axons", "has", "been", "measured", "using", "glass", "pH", "microelectrodes"], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [9, 10]}}
{"token": ["The", "ion", "transport", "system", "for", "intracellular", "pH", "(", "C1704947#ent", "<e1>", ")", "regulation", "in", "squid", "C0017547#ent", "<e2>", "axons", "was", "examined", "in", "experiments", "with", "pH-sensitive", "microelectrodes", "isotopic", "fluxes", "of", "Na+", "and", "Cl-", "."], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [14, 15]}}
{"token": ["C1721673#ent", "<e1>", ",", "also", "known", "as", "ALDH", "class", "1", "ALDH1", ")", "or", "retinaldehyde", "dehydrogenase", "C1412333#ent", "<e2>", ")", ",", "prefers", "retinal", "to", "acetaldehyde", "as", "a", "substrate", "."], "h": {"id": "C1721673", "name": "C1721673#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412333", "name": "C1412333#ent", "pos": [14, 15]}}
{"token": ["Two", "other", "sequences", ",", "16-YYSTPI-21", "and", "105-NGNKSVWCQANN-116", ",", "are", "located", "between", "C1425577#ent", "<e1>", "and", "Cys2", "of", "C1413694#ent", "<e2>", "and", "around", "Cys3", "of", "SCR2", ",", "respectively", "."], "h": {"id": "C1425577", "name": "C1425577#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413694", "name": "C1413694#ent", "pos": [16, 17]}}
{"token": ["C0011588#ent", "<e1>", "was", "found", "to", "be", "an", "effective", "C0001645#ent", "<e2>", "."], "h": {"id": "C0011588", "name": "C0011588#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [8, 9]}}
{"token": ["Twenty-four", "consecutive", "patients", "with", "symptomatic", "nasal", "polyposis", "nonallergic", "or", "C0035457#ent", "<e1>", "were", "undergoing", "chronic", "nasal", "steroid", "therapy", "prospectively", "evaluated", "for", "response", "to", "adjunctive", "oral", "C0298130#ent", "<e2>"], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0298130", "name": "C0298130#ent", "pos": [24, 25]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "investigate", "effects", "of", "pretreatment", "of", "C0035457#ent", "<e1>", "AR", ")", "with", "cetirizine", ",", "and", "C0298130#ent", "<e2>", ",", "alone", "and", "in", "combination", "."], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0298130", "name": "C0298130#ent", "pos": [20, 21]}}
{"token": ["Like", "the", "DeltacnaA", "strain", ",", "the", "DeltacrzA", "strain", "was", "incapable", "of", "causing", "disease", "in", "an", "experimental", "persistently", "C0027947#ent", "<e1>", "inhalational", "murine", "model", "of", "invasive", "C2350530#ent", "<e2>"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2350530", "name": "C2350530#ent", "pos": [24, 25]}}
{"token": ["Asthma", "management", "strategies", "coupled", "with", "new", "formulations", "of", "asthma", "medications", ",", "such", "as", "C0772501#ent", "<e1>", ",", "can", "significantly", "reduce", "asthma", "symptoms", "during", "C0006266#ent", "<e2>"], "h": {"id": "C0772501", "name": "C0772501#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [22, 23]}}
{"token": ["The", "full-length", "cDNAs", "for", "C1421171#ent", "<e1>", ",", "TRP6", ",", "and", "C1428200#ent", "<e2>", ",", "as", "well", "as", "one", "splice", "variant", "C1421171#ent", "<e1>", "and", "two", "splice", "variants", "C1428200#ent", "<e2>", ",", "were", "cloned", "from", "murine", "colonic", "smooth", "muscle"], "h": {"id": "C1428200", "name": "C1428200#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421171", "name": "C1421171#ent", "pos": [4, 5]}}
{"token": ["The", "C0016377#ent", "<e1>", "mRNA", "synthesized", "in", "vitro", "C1335439#ent", "<e2>", "translated", "efficiently", "in", "a", "rabbit", "reticulocyte", "lysate", "produce", "enzymatically", "active", "C0016377#ent", "<e1>", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [7, 8]}}
{"token": ["Toads", "dehydrated", "by", "more", "than", "10", "%", "showed", "significantly", "shorter", "periods", "of", "C3273505#ent", "<e1>", "behavior", "and", "initiated", "WR", "behavior", "frequently", "than", "did", "C0008161#ent", "<e2>", "toads", "."], "h": {"id": "C3273505", "name": "C3273505#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008161", "name": "C0008161#ent", "pos": [22, 23]}}
{"token": ["To", "evaluate", "macular", "and", "nerve", "fiber", "layer", "C2981619#ent", "<e1>", ")", "thickness", "in", "normal", "and", "C0017601#ent", "<e2>", "eyes", "of", "children", "3", "to", "17", "years", "old", "using", "optical", "coherence", "tomography", "OCT-3", ")", "."], "h": {"id": "C2981619", "name": "C2981619#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [14, 15]}}
{"token": ["The", "percent", "area", "of", "fluorescein", "defect", "the", "optic", "disc", "increased", "with", "severity", "of", "C2981619#ent", "<e1>", "defect", "in", "C0017601#ent", "<e2>", "and", "ocular", "hypertension"], "h": {"id": "C2981619", "name": "C2981619#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [17, 18]}}
{"token": ["Plasma", "C1333522#ent", "<e1>", "levels", "in", "patients", "with", "C0155626#ent", "<e2>", "on", "admission", "were", "significantly", "higher", "than", "in", "the", "chest", "pain", "syndrome", "stable", "exertional", "angina", "groups", "(", "248.0+/-117", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [7, 8]}}
{"token": ["C1453853#ent", "<e1>", "ATM", "inhibits", "wild-type", "ATM", "phosphorylation", "of", "C1424448#ent", "<e2>", ",", "consistent", "with", "dominant-negative", "effect", "of", "kinase-deficient", "ATM", "in", "vivo"], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424448", "name": "C1424448#ent", "pos": [8, 9]}}
{"token": ["Computer", "simulation", "C0036516#ent", "<e1>", "distribution", "has", "strongly", "suggested", "the", "elimination", "of", "this", "C1254351#ent", "<e2>", "in", "bile", "and", "that", "the", "rebound", "rise", "in", "liver", "amy", "due", "to", "enterohepatic", "circulation"], "h": {"id": "C0036516", "name": "C0036516#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["Cocaine", ",", "methylphenidate", "and", "C0036516#ent", "<e1>", "were", "compared", "on", "a", "C1254351#ent", "<e2>", "maintained", "progressive-ratio", "procedure", "in", "baboon", "subjects", "."], "h": {"id": "C0036516", "name": "C0036516#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}}
{"token": ["C0022180#ent", "<e1>", "determined", "before", "and", "after", "each", "dose", "of", "C0104808#ent", "<e2>", "."], "h": {"id": "C0022180", "name": "C0022180#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0104808", "name": "C0104808#ent", "pos": [9, 10]}}
{"token": ["To", "delineate", "the", "interaction", "between", "IGF-I", "and", "C1334096#ent", "<e1>", "on", "wv", "granule", "neurons", ",", "we", "examined", "C1420257#ent", "<e2>", "treating", "with", "IGF-I", ",", "des(1", "-", "3", ")", "IGF-I", ",", "or", "C1334096#ent", "<e1>", "antibody", "."], "h": {"id": "C1334096", "name": "C1334096#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [16, 17]}}
{"token": ["The", "interaction", "between", "C1706390#ent", "<e1>", "and", "C1419318#ent", "<e2>", "had", "a", "functional", "consequence", ":", "the", "combination", "of", "C1419318#ent", "<e2>", "and", "C1706390#ent", "<e1>", "gave", "higher", "transcription", "in", "vitro", "than", "C1706390#ent", "<e1>", "alone", "."], "h": {"id": "C1419318", "name": "C1419318#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706390", "name": "C1706390#ent", "pos": [3, 4]}}
{"token": ["Treatment", "should", "consist", "of", "abstinence", "from", "C0001962#ent", "<e1>", ",", "sodium", "restricted", "diet", ",", "and", "C0596110#ent", "<e2>", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [14, 15]}}
{"token": ["Direct", "and", "indirect", "effects", "of", "C0001962#ent", "<e1>", ",", "a", "secondary", "hyperaldosteronism", "the", "use", "of", "C0596110#ent", "<e2>", ",", "and", "hypoalbuminaemia", "could", "account", "for", "magnesium", "serum", "level", "decrease", "in", "liver", "cirrhosis"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [14, 15]}}
{"token": ["We", "were", "not", "able", "to", "demonstrate", "any", "changes", "in", "VIP", "mRNA", "in", "the", "cerebral", "cortex", "C0032002#ent", "<e1>", "of", "the", "C0020550#ent", "<e2>", "rats", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [19, 20]}}
{"token": ["Serum", "angiotensin", "converting", "enzyme", "ACE", ")", "activities", "were", "determined", "in", "patients", "with", "different", "types", "of", "C0029400#ent", "<e1>", "the", "gastrointestinal", "tract", "in", "patients", "with", "C0030920#ent", "<e2>", "and", "in", "healthy", "volunteer", "subjects"], "h": {"id": "C0029400", "name": "C0029400#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [23, 24]}}
{"token": ["The", "potency", "ratios", "after", "pretreatment", "with", "C0039663#ent", "<e1>", "for", "heroin", "and", "C0025376#ent", "<e2>", "indicated", "significant", "enhancement", "(", "4.1", "and", "8.9", ",", "respectively", ")", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025376", "name": "C0025376#ent", "pos": [11, 12]}}
{"token": ["In", "a", "patient", "with", "C0022336#ent", "<e1>", "cortical", "excitability", "was", "suppressed", "between", "C0027066#ent", "<e2>"], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0027066", "name": "C0027066#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "family", "in", "which", "four", "patients", "developed", "classical", "clinical", "signs", "C0022336#ent", "<e1>", ",", "including", "severe", "cognitive", "decline", "cerebellar", "signs", "C0027066#ent", "<e2>", "and", "synchronic", "periodic", "discharges", "electroencephalogram", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0027066", "name": "C0027066#ent", "pos": [21, 22]}}
{"token": ["Indeed", ",", "Cat", "S", "null", "mice", "resistant", "to", "I-Ab-restricted", "experimental", "C0026896#ent", "<e1>", "to", "inadequate", "C0030956#ent", "<e2>", "presentation", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}}
{"token": ["Most", "patients", "with", "C0026896#ent", "<e1>", "T-cell", "reactivities", "to", "1", "to", "6", "different", "C0030956#ent", "<e2>", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["In", "this", "paper", "we", "report", "the", "synthesis", "of", "analogues", "in", "which", "both", "of", "the", "side", "chains", "the", "guanidine", "group", "modified", "and", "tested", "as", "C2987634#ent", "<e1>", "or", "antagonists", "at", "C1439352#ent", "<e2>", "guinea", "pig", "atrium", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1439352", "name": "C1439352#ent", "pos": [28, 29]}}
{"token": ["Imidazolylpropylguanidines", "derived", "from", "impromidine", "and", "arpromidine", "are", "more", "potent", "and", "efficacious", "C2987634#ent", "<e1>", "at", "the", "guinea", "pig", "C1439352#ent", "<e2>", "gpH2R", ")", "than", "at", "the", "human", "H2R", "(", "hH2R", ")", "in", "the", "GTPase", "assay"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1439352", "name": "C1439352#ent", "pos": [17, 18]}}
{"token": ["Under", "the", "agreement", "terms", ",", "C0270221#ent", "<e1>", "will", "receive", "an", "upfront", "fee", "from", "C1414672#ent", "<e2>", ",", "as", "well", "as", "milestone", "payments", "on", "reaching", "certain", "sales", "levels", "the", "territory", "."], "h": {"id": "C0270221", "name": "C0270221#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [13, 14]}}
{"token": ["The", "most", "important", "differential", "diagnoses", "of", "PAN", "of", "the", "breast", "are", "infectious", "mastitis", "mammary", "malignancy", "other", "forms", "of", "C0042384#ent", "<e1>", "the", "breast", ",", "e.g.", "C0039483#ent", "<e2>", "Wegener", "granulomatosis"], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0039483", "name": "C0039483#ent", "pos": [24, 25]}}
{"token": ["hemA", ",", "C0008533#ent", "<e1>", ",", "hemC", ",", "and", "C1332075#ent", "<e2>", "have", "all", "been", "shown", "to", "be", "essential", "for", "heme", "synthesis"], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332075", "name": "C1332075#ent", "pos": [8, 9]}}
{"token": ["Identification", "of", "C0017337#ent", "<e1>", "regulated", "by", "C1257954#ent", "<e2>", "lead", "to", "a", "better", "understanding", "of", "their", "proapoptotic", "and", "anti-neoplastic", "activities"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [6, 7]}}
{"token": ["Because", "we", "determined", "that", "a", "mutant", "of", "C1421311#ent", "<e1>", "was", "viable", ",", "three", "candidate", "C0017337#ent", "<e2>", "remain", "within", "the", "region", "."], "h": {"id": "C1421311", "name": "C1421311#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["C0985528#ent", "<e1>", "was", "also", "found", "to", "induce", "C0029408#ent", "<e2>", "activity", ",", "but", "not", "morphologic", "transformation"], "h": {"id": "C0985528", "name": "C0985528#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [7, 8]}}
{"token": ["The", "ratios", "of", "2", ",", "3-DHBA/SA", "were", "significantly", "higher", "in", "plasma", "and", "liver", "of", "hepatitic", "C1419876#ent", "<e1>", "rats", "than", "those", "of", "Wistar", "rats", "C1419876#ent", "<e1>", "rats", "showing", "no", "signs", "C0019159#ent", "<e1>", "."], "h": {"id": "C1419876", "name": "C1419876#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [29, 30]}}
{"token": ["To", "determine", "which", "acidic", "amino", "acid", "receptor", "the", "network-selective", "action", "of", "DOS", ",", "various", "C0242910#ent", "<e1>", "tested", "against", "this", "C0243046#ent", "<e2>", "EAAR", ")", "antagonist", "."], "h": {"id": "C0242910", "name": "C0242910#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [19, 20]}}
{"token": ["A", "new", "experimental", "approach", "offered", "by", "C0242910#ent", "<e1>", "which", "may", "prevent", "cell", "damage", "induced", "by", "the", "C0243046#ent", "<e2>"], "h": {"id": "C0242910", "name": "C0242910#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [16, 17]}}
{"token": ["Rapid", "onset", "of", "sedation", "was", "seen", "after", "sublingual", "C0065185#ent", "<e1>", ",", "while", "the", "course", "and", "C0720099#ent", "<e2>", "of", "postoperative", "sedation", ",", "measured", "using", "standard", "psychometric", "tests", "was", "similar", "following", "both", "treatments", "."], "h": {"id": "C0065185", "name": "C0065185#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [15, 16]}}
{"token": ["The", "most", "frequently", "studied", "genetic", "polymorphisms", "the", "restriction", "fragment", "polymorphisms", "PstI/", "RsaI", "(", "mutant", "allele", "CYP2E1*5B", "located", "in", "the", "5'-flanking", "region", "the", "C0017337#ent", "<e1>", ",", "as", "well", "as", "the", "DraI", "polymorphism", "mutant", "allele", "C0010763#ent", "<e2>", "located", "in", "intron", "6"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [33, 34]}}
{"token": ["The", "review", "focuses", "on", "several", "related", "C0017337#ent", "<e1>", "that", "control", "alcohol", "metabolism", "as", "alcohol", "dehydrogenase", "aldehyde", "dehydrogenase", "C0010763#ent", "<e2>", "regulate", "neurotransmission", "such", "as", "catechol-O-methyltransferase", ",", "dopamine", "receptors", "D2", "D4", ",", "and", "mu", "opioid", "receptor"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [17, 18]}}
{"token": ["C1282208#ent", "<e1>", "a", "severe", "infection", "presenting", "with", "proptosis", "and", "C0155338#ent", "<e2>", ";", "it", "requires", "hospitalization", "and", "intravenous", "antibiotics", "prevent", "vision", "loss"], "h": {"id": "C1282208", "name": "C1282208#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0155338", "name": "C0155338#ent", "pos": [9, 10]}}
{"token": ["The", "yield", "of", "new", "cases", "of", "C3714618#ent", "<e1>", "hypothyroidism", "was", "low", ",", "but", "a", "presumptive", "diagnosis", "C3665349#ent", "<e2>", "made", "in", "eight", "patients", "."], "h": {"id": "C3714618", "name": "C3714618#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [16, 17]}}
{"token": ["The", "objective", "was", "to", "assess", "the", "success", "rate", "patients", "receiving", "surgery", "or", "radioactive", "iodine", "C3714618#ent", "<e1>", "the", "incidence", "of", "subsequent", "C3665349#ent", "<e2>", "."], "h": {"id": "C3714618", "name": "C3714618#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [20, 21]}}
{"token": ["However", ",", "its", "role", "in", "chronic", "immune", "mediated", "C0029132#ent", "<e1>", "such", "as", "multifocal", "motor", "neuropathy", "MMN", ")", "or", "C3542501#ent", "<e2>", "CIDP", ")", "is", "less", "clear", "."], "h": {"id": "C0029132", "name": "C0029132#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3542501", "name": "C3542501#ent", "pos": [18, 19]}}
{"token": ["These", "dysimmune", "processes", "can", "result", "in", "various", "C0029132#ent", "<e1>", ",", "such", "as", "C3542501#ent", "<e2>", "or", "C0029132#ent", "<e1>", "secondary", "to", "secretion", "of", "a", "monoclonal", "immunoglobulin"], "h": {"id": "C0029132", "name": "C0029132#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3542501", "name": "C3542501#ent", "pos": [12, 13]}}
{"token": ["C0384323#ent", "<e1>", "completely", "blocked", "the", "inhibitory", "effect", "of", "C0173792#ent", "<e2>", "on", "the", "acetylcholine", "response"], "h": {"id": "C0384323", "name": "C0384323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0173792", "name": "C0173792#ent", "pos": [8, 9]}}
{"token": ["The", "results", "indicate", "that", "the", "protective", "effect", "fish", "oil", "achieved", "by", "decreasing", "the", "C0108342#ent", "<e1>", "concentration", "and", "normalizing", "C0003402#ent", "<e2>", "enzymes", "."], "h": {"id": "C0108342", "name": "C0108342#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [18, 19]}}
{"token": ["The", "content", "of", "cationic", "protein", "blood", "neutrophils", "the", "serum", "activity", "lysosomal", "enzymes", "the", "intensity", "of", "C0108342#ent", "<e1>", "lipid", "oxidation", ",", "the", "C0003402#ent", "<e2>", "and", "the", "blood", "concentration", "trace", "elements", "assessed", "in", "patients", "with", "burn", "injury"], "h": {"id": "C0108342", "name": "C0108342#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [21, 22]}}
{"token": ["Subsequently", ",", "we", "examine", "published", "data", "allergic", "rhinitis", "C1705516#ent", "<e1>", ",", "and", "summarize", "the", "effect", "of", "treatment", "of", "C0009443#ent", "<e2>", "on", "C1705516#ent", "<e1>", "."], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [18, 19]}}
{"token": ["Analysis", "of", "the", "products", "in", "E.", "coli", "that", "in", "addition", "to", "the", "two", "C1335494#ent", "<e1>", "118", "and", "80", "kDa", "the", "pri", "region", "C3151001#ent", "<e2>", "encodes", "two", "smaller", "proteins", "of", "16.5", "and", "8.6", "kDa", "."], "h": {"id": "C1335494", "name": "C1335494#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3151001", "name": "C3151001#ent", "pos": [22, 23]}}
{"token": ["Our", "previous", "studies", "have", "determined", "that", "depletion", "of", "intracellular", "polyamines", "by", "C0282042#ent", "<e1>", "a", "marked", "decrease", "in", "the", "transcription", "of", "the", "human", "C0079068#ent", "<e2>"], "h": {"id": "C0282042", "name": "C0282042#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [22, 23]}}
{"token": ["Levosimendan", "increases", "the", "sensitivity", "of", "the", "cardiac", "fibrils", "C2936886#ent", "<e1>", ",", "favorably", "affects", "hemodynamics", "in", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [17, 18]}}
{"token": ["Using", "the", "ELISA", "method", "the", "authors", "assessed", "titres", "of", "antibodies", "to", "collagen", "type", "I", "C3273406#ent", "<e1>", "and", "III", "in", "serum", "of", "patients", "with", "juvenile", "chronic", "arthritis", "C3890557#ent", "<e2>", ")", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3890557", "name": "C3890557#ent", "pos": [26, 27]}}
{"token": ["C1336665#ent", "<e1>", "encodes", "the", "C2698694#ent", "<e2>", "the", "central", "portion", "the", "gene", ",", "and", "plays", "a", "crucial", "role", "in", "the", "developmental", "lineage", "bone", "and", "cartilage", ",", "especially", "in", "head", "formation"], "h": {"id": "C1336665", "name": "C1336665#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2698694", "name": "C2698694#ent", "pos": [4, 5]}}
{"token": ["A", "further", "sevenfold", "increase", "in", "nuclease", "sensitivity", "was", "detected", "in", "C0017337#ent", "<e1>", "actively", "being", "transcribed", "(", "C2987341#ent", "<e2>", "and", "AFP", "C0017337#ent", "<e1>", "in", "embryo", "liver", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987341", "name": "C2987341#ent", "pos": [16, 17]}}
{"token": ["C1412481#ent", "<e1>", "has", "been", "shown", "to", "influence", "C0078939#ent", "<e2>", "Abeta", ")", "and", "amyloid", "burden", ",", "both", "in", "humans", "and", "in", "transgenic", "mice"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [7, 8]}}
{"token": ["The", "focal", "adhesion", "kinase", "C1565427#ent", "<e1>", ")", "is", "a", "nonreceptor", "protein", "tyrosine", "kinase", "in", "integrin-mediated", "signal", "transduction", "pathways", "oncogenic", "transformation", "C3853557#ent", "<e2>", ",", "and", "the", "invasion", "of", "human", "tumors"], "h": {"id": "C1565427", "name": "C1565427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3853557", "name": "C3853557#ent", "pos": [20, 21]}}
{"token": ["Conversely", ",", "inhibition", "of", "PI3K", "silencing", "of", "C1420556#ent", "<e1>", "by", "small", "RNA", "interference", "siRNA", ")", "blocked", "the", "effect", "of", "C0966149#ent", "<e2>", "on", "PTEN", "expression", "and", "on", "NSCLC", "cell", "proliferation"], "h": {"id": "C1420556", "name": "C1420556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0966149", "name": "C0966149#ent", "pos": [19, 20]}}
{"token": ["Taken", "together", ",", "our", "results", "suggest", "that", "C3537285#ent", "<e1>", "expression", "is", "differentiation-dependent", "and", "selectively", "regulated", "by", "C3539616#ent", "<e2>", "implying", "a", "potential", "role", "of", "this", "hormone", "in", "adiponectin-associated", "alterations", "of", "insulin", "sensitivity", "energy", "homeostasis"], "h": {"id": "C3537285", "name": "C3537285#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [16, 17]}}
{"token": ["Phylogenetic", "relationships", "inferred", "using", "nucleotide", "sequence", "variation", "of", "the", "nuclear-encoded", "chalcone", "synthase", "gene", "(", "C0007965#ent", "<e1>", ")", "and", "the", "C3179066#ent", "<e2>", "members", "of", "five", "tribes", "from", "the", "family", "Brassicaceae", "analyze", "tribal", "and", "subtribal", "structures", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [19, 20]}}
{"token": ["The", "original", "strain", "BITS", "was", "cultivated", "in", "C4284622#ent", "<e1>", "medium", "supplemented", "with", "increasing", "concentrations", "of", "C1512488#ent", "<e2>", "hyperimmune", "serum", "raised", "in", "rabbits", "."], "h": {"id": "C4284622", "name": "C4284622#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [15, 16]}}
{"token": ["human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "C3273837#ent", "<e1>", "interacts", "with", "the", "clathrin-associated", "C0162508#ent", "<e2>", "and", "AP-3", "adaptor", "complexes", "stabilizing", "their", "association", "with", "endosomal", "membranes"], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [13, 14]}}
{"token": ["These", "data", "indicate", "that", "C3273837#ent", "<e1>", "mediates", "the", "persistent", "attachment", "of", "C0162508#ent", "<e2>", "and", "AP-3", "to", "membranes", "by", "an", "ARF1-independent", "mechanism", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [11, 12]}}
{"token": ["Genes", "predicting", "interactions", "with", "host", "cellular", "mechanisms", "include", "C1334043#ent", "<e1>", "of", "the", "inhibitor", "of", "apoptosis", "protein", "C0247248#ent", "<e2>", "extracellular", "matrixin", "metalloproteases", "ubiquitin", ",", "calcium", "binding", "EF-hand", "protein", "glycosyltransferase", ",", "and", "a", "triacylglyceride", "lipase"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0247248", "name": "C0247248#ent", "pos": [16, 17]}}
{"token": ["Incomplete", "C0796110#ent", "<e1>", "some", "of", "the", "features", "of", "the", "complete", "C0796110#ent", "<e1>", "lacking", ",", "and", "the", "patient", "shows", "emotional", "reactions", "appropriate", "C0239779#ent", "<e1>", "and", "some", "appropriate", "motor", "responses"], "h": {"id": "C0796110", "name": "C0796110#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0239779", "name": "C0239779#ent", "pos": [21, 22]}}
{"token": ["We", "previously", "reported", "that", "C0673297#ent", "<e1>", ",", "a", "purified", "polysaccharide", "isolated", "from", "C0873137#ent", "<e2>", "had", "a", "mitogenic", "activity", "induced", "LAK", "cells", "and", "increased", "levels", "of", "several", "cytokines", "."], "h": {"id": "C0673297", "name": "C0673297#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0873137", "name": "C0873137#ent", "pos": [12, 13]}}
{"token": ["C0673297#ent", "<e1>", "is", "a", "polysaccharide", "extracted", "from", "the", "roots", "of", "C0873137#ent", "<e2>", "and", "it", "has", "earlier", "been", "reported", "to", "have", "an", "immunostimulatory", "effect", "."], "h": {"id": "C0673297", "name": "C0673297#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0873137", "name": "C0873137#ent", "pos": [10, 11]}}
{"token": ["We", "show", "that", "RhoG(GTP", ")", "specifically", "interacts", "with", "the", "central", "domain", "C1416766#ent", "<e1>", ",", "which", "also", "contains", "a", "C0084340#ent", "<e2>", "binding", "domain", "its", "C", "terminus", "."], "h": {"id": "C1416766", "name": "C1416766#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [18, 19]}}
{"token": ["The", "recombinant", "aequorin", "gene", "from", "the", "C0885254#ent", "<e1>", "Aequorea", "victoria", "for", "the", "expression", "of", "the", "C1413043#ent", "<e2>", "+", "-sensitive", "aequorin", "photoprotein", "has", "been", "cloned", "in", "the", "filamentous", "fungus", "Aspergillus", "awamori"], "h": {"id": "C0885254", "name": "C0885254#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [15, 16]}}
{"token": ["BCR", "activation", "induced", "tyrosine", "phosphorylation", "C1413923#ent", "<e1>", "and", "translocation", "of", "both", "C1413923#ent", "<e1>", "and", "C1414120#ent", "<e1>", "the", "cytoplasm", "to", "plasma", "membrane", "where", "they", "colocalized", "with", "the", "BCR", "and", "cortical", "F-actin", "."], "h": {"id": "C1413923", "name": "C1413923#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "the", "presence", "of", "a", "protease", "inhibitor", "leupeptin", ",", "in", "the", "incubation", "medium", "the", "menadione-induced", "decrease", "in", "the", "amount", "of", "C1413923#ent", "<e1>", "not", "the", "decrease", "in", "the", "other", "C1414120#ent", "<e2>"], "h": {"id": "C1413923", "name": "C1413923#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [29, 30]}}
{"token": ["In", "this", "study", ",", "we", "have", "identified", "the", "C1413923#ent", "<e1>", "filamin", "(", "ABP-280", ")", ",", "as", "a", "major", "C1414120#ent", "<e2>", "binds", "to", "the", "cytoplasmic", "tail", "the", "beta", "2-integrin", "subunit", "CD18", "."], "h": {"id": "C1413923", "name": "C1413923#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [18, 19]}}
{"token": ["We", "also", "identified", "that", "C0919534#ent", "<e1>", "null", "genotype", "a", "candidate", "C0079429#ent", "<e2>", "for", "susceptibility", "to", "SS", "and", "was", "associated", "with", "autoantibody", "production", "."], "h": {"id": "C0919534", "name": "C0919534#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}}
{"token": ["Associations", "were", "also", "observed", "for", "polymorphisms", "of", "C1420395#ent", "<e1>", "and", "ERalpha", "with", "C3813197#ent", "<e2>", "and", "SBP", "in", "males", ",", "respectively", "."], "h": {"id": "C1420395", "name": "C1420395#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3813197", "name": "C3813197#ent", "pos": [12, 13]}}
{"token": ["C3273474#ent", "<e1>", "interacts", "with", "C1419769#ent", "<e2>", "and", "undergoes", "a", "complex", "posttranslational", "hyperphosphorylation", ",", "generating", "species", "with", "reduced", "polyacrylamide", "gel", "electrophoresis", "mobility"], "h": {"id": "C3273474", "name": "C3273474#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419769", "name": "C1419769#ent", "pos": [4, 5]}}
{"token": ["The", "predicted", "amino", "acid", "sequence", "the", "amino-terminal", "portion", "C1424769#ent", "<e1>", "was", "similar", "to", "C1420332#ent", "<e2>", ",", "a", "previously", "identified", "NB", "protein"], "h": {"id": "C1424769", "name": "C1424769#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420332", "name": "C1420332#ent", "pos": [13, 14]}}
{"token": ["Previously", "reported", "proteins", "in", "the", "C1704943#ent", "<e1>", "signal", "pathway", "identified", "including", "PI3-K", ",", "C0169661#ent", "<e2>", ",", "Jak3", ",", "Stat3", ",", "Grb2", ",", "IRS", ",", "and", "PLCgamma1", "."], "h": {"id": "C1704943", "name": "C1704943#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0169661", "name": "C0169661#ent", "pos": [13, 14]}}
{"token": ["C1282975#ent", "<e1>", "VWD", ")", "refers", "to", "patients", "with", "a", "C1366370#ent", "<e2>", "FVIII", ")", "deficiency", "caused", "by", "a", "markedly", "decreased", "affinity", "of", "von", "Willebrand", "factor", "VWF", ")", "for", "FVIII", "."], "h": {"id": "C1282975", "name": "C1282975#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [9, 10]}}
{"token": ["Diagnosis", "of", "C1282975#ent", "<e1>", "vWD", "2N", ",", "which", "mimics", "C1366370#ent", "<e2>", "its", "carrier", "state", "is", "important", "for", "accurate", "genetic", "counseling", "appropriate", "therapy", "."], "h": {"id": "C1282975", "name": "C1282975#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [9, 10]}}
{"token": ["C1282975#ent", "<e1>", "vWD", ")", "can", "be", "confused", "with", "C1366370#ent", "<e2>", "to", "decreased", "factor", "VIII", "levels", "and", "a", "bleeding", "tendency", ",", "and", "differential", "diagnosis", "of", "importance", "for", "providing", "the", "optimal", "treatment", "and", "genetic", "counseling"], "h": {"id": "C1282975", "name": "C1282975#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [8, 9]}}
{"token": ["According", "to", "Fourier", "transform", "infrared", "spectroscopy", "FTIR", ")", "and", "circular", "dichroism", "C1705969#ent", "<e1>", ")", "data", ",", "IL-1beta", "and", "C1418757#ent", "<e2>", "are", "typical", "beta-structural", "proteins"], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418757", "name": "C1418757#ent", "pos": [18, 19]}}
{"token": ["This", "study", "evaluated", "whether", "C0215263#ent", "<e1>", "administered", "at", "a", "certain", "period", "after", "C0151744#ent", "<e2>", "the", "same", "cardioprotection", "and", "assessed", "its", "possible", "new", "mechanism", "."], "h": {"id": "C0215263", "name": "C0215263#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [12, 13]}}
{"token": ["SB203580", ",", "a", "specific", "C1456380#ent", "<e1>", "protected", "the", "C1332416#ent", "<e2>", "expression", "and", "decreased", "the", "levels", "of", "gamma-H2AX", "and", "apoptosis", "in", "the", "celecoxib-exposed", "cells", "."], "h": {"id": "C1456380", "name": "C1456380#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [8, 9]}}
{"token": ["Normal", "tissue", "C0907533#ent", "<e1>", "expression", "of", "C1363984#ent", "<e2>", "in", "the", "vasculature", "of", "the", "optic", "nerve", "heads", "no", "positive", "labeling", "for", "TNF-alpha", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1363984", "name": "C1363984#ent", "pos": [6, 7]}}
{"token": ["Northern", "blotting", "that", "all", "three", "types", "of", "glia", "C0907533#ent", "<e1>", "transcribed", "a", "single", "C1363984#ent", "<e2>", "mRNA", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1363984", "name": "C1363984#ent", "pos": [13, 14]}}
{"token": ["The", "most", "common", "complications", "are", "intestinal", "bleeding", "perforation", "and", "necrotizing", "cholecystitis", "although", "C0019159#ent", "<e1>", ",", "myocarditis", ",", "nephritis", ",", "and", "C0025289#ent", "<e2>", "may", "occur", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [20, 21]}}
{"token": ["The", "most", "frequently", "encountered", "medical", "problems", "on", "Tanna", "were", "infectious", "diseases", "tuberculosis", ",", "C0019159#ent", "<e1>", ",", "abscesses", ",", "malaria", ",", "pneumonia", ",", "typhoid", "fever", "C0025289#ent", "<e2>", "and", "skin", "infections", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [24, 25]}}
{"token": ["Therefore", ",", "we", "sought", "to", "determine", "whether", "the", "protective", "effect", "C0005304#ent", "<e1>", "is", "via", "its", "effect", "on", "C0070788#ent", "<e2>", "activity", "."], "h": {"id": "C0005304", "name": "C0005304#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0070788", "name": "C0070788#ent", "pos": [17, 18]}}
{"token": ["A", "highly", "enantioselective", "and", "convergent", "synthesis", "of", "C0257217#ent", "<e1>", "52", "(", "2", ")", ",", "an", "exceedingly", "potent", "C0304497#ent", "<e2>", "is", "described", "."], "h": {"id": "C0257217", "name": "C0257217#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0304497", "name": "C0304497#ent", "pos": [17, 18]}}
{"token": ["An", "efficient", "and", "highly", "stereoselective", "synthesis", "of", "C0257217#ent", "<e1>", "2", ")", ",", "a", "potent", "C0304497#ent", "<e2>", "is", "described", "."], "h": {"id": "C0257217", "name": "C0257217#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0304497", "name": "C0304497#ent", "pos": [14, 15]}}
{"token": ["C0010678#ent", "<e1>", "is", "a", "C0043528#ent", "<e2>", "humans", "produced", "by", "the", "larval", "stage", "of", "swine", "parasite", "Taenia", "solium"], "h": {"id": "C0010678", "name": "C0010678#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [4, 5]}}
{"token": ["Like", "the", "thioredoxins", "and", "C0061505#ent", "<e1>", ",", "it", "is", "a", "C1824324#ent", "<e2>", "pI", "=", "4.2", ")", "consisting", "of", "83", "amino", "acids", "M(r", ")", "=", "9136", ")", "."], "h": {"id": "C0061505", "name": "C0061505#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1824324", "name": "C1824324#ent", "pos": [10, 11]}}
{"token": ["Molecular", "defects", "the", "genes", "for", "GPIbalpha", ",", "GPIbbeta", ",", "and", "C4284289#ent", "<e1>", "give", "rise", "to", "the", "Bernard-Soulier", "syndrome", "in", "which", "C0040034#ent", "<e2>", "and", "giant", "platelets", "suggest", "that", "this", "receptor", "also", "is", "involved", "in", "platelet", "production"], "h": {"id": "C4284289", "name": "C4284289#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [20, 21]}}
{"token": ["Mutations", "in", "the", "C1420280#ent", "<e1>", "PDZ", "domain-containing", "protein", "harmonin", "the", "causes", "of", "Usher", "syndrome", "type", "1C", "C1421379#ent", "<e2>", ")", ",", "a", "syndrome", "of", "congenital", "deafness", "progressive", "blindness", ",", "as", "well", "as", "certain", "forms", "of", "non-syndromic", "deafness", "."], "h": {"id": "C1420280", "name": "C1420280#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421379", "name": "C1421379#ent", "pos": [16, 17]}}
{"token": ["The", "C1457887#ent", "<e1>", "Takayasu", "arteritis", "be", "mainly", "systemic", "and", "may", "resemble", "C0521516#ent", "<e2>", "rheumatica", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0521516", "name": "C0521516#ent", "pos": [11, 12]}}
{"token": ["C1457887#ent", "<e1>", "be", "mainly", "systemic", "and", "may", "resemble", "C0521516#ent", "<e2>", "rheumatica", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0521516", "name": "C0521516#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "degree", "of", "expression", "of", "B7", "-", "1", "and", "B7", "-", "2", "C2985420#ent", "<e1>", "a", "significant", "correlation", "with", "C0033036#ent", "<e2>", "capacity", "."], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [20, 21]}}
{"token": ["B", "lymphocytes", "class", "II", "molecules", "can", "also", "be", "induced", "to", "express", "C2985420#ent", "<e1>", "allowing", "them", "to", "act", "as", "C0033036#ent", "<e2>", "to", "Th", "cells"], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [18, 19]}}
{"token": ["Others", "have", "shown", "that", "mutation", "of", "daf-18", "suppresses", "the", "life", "extension", "C0669365#ent", "<e1>", "dauer", "formation", "associated", "with", "or", "C3537341#ent", "<e2>", "mutants", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3537341", "name": "C3537341#ent", "pos": [18, 19]}}
{"token": ["We", "find", "that", "an", "activated", "Ras", "mutation", "let-60(n1046gf", ")", ",", "weakly", "suppresses", "C0669365#ent", "<e1>", "dauer", "diapause", "in", "daf-2", "and", "C3537341#ent", "<e2>", "(", "PI3K", "mutants", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3537341", "name": "C3537341#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "C3272518#ent", "<e1>", "based", "on", "AAO", "templates", "were", "produced", "using", "acetylene", "or", "C0015075#ent", "<e2>", "as", "the", "hydrocarbon", "sources", "or", "without", "the", "presence", "of", "Co", "catalysts"], "h": {"id": "C3272518", "name": "C3272518#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015075", "name": "C0015075#ent", "pos": [13, 14]}}
{"token": ["Methods", "for", "separation", "of", "isoenzymes", "using", "high-performance", "(", "pressure", ")", "liquid", "chromatography", "been", "adapted", "for", "analysis", "of", "C0684287#ent", "<e1>", "ALDH", ")", "(", "aldehyde", ":", "C0030016#ent", "<e2>", "EC", "1.2.1.3", "isoenzymes", "in", "canine", "liver", "."], "h": {"id": "C0684287", "name": "C0684287#ent", "pos": [17, 18]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [24, 25]}}
{"token": ["The", "genome", "of", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "encodes", "at", "least", "six", "C0086376#ent", "<e1>", "involved", "in", "regulation", "as", "well", "as", "the", "structural", "proteins", "C0017346#ent", "<e2>", ",", "Pol", ",", "and", "Env", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [25, 26]}}
{"token": ["No", "significant", "decrease", "was", "noted", "for", "the", "IgA", "directed", "towards", "the", "other", "C0086376#ent", "<e1>", "of", "HIV-1", ",", "especially", "the", "products", "of", "the", "C0017346#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [22, 23]}}
{"token": ["A", "novel", "C0059181#ent", "<e1>", "polymorphic", "site", "by", "a", "T-->G", "transversion", "at", "codon", "40", "the", "C1704693#ent", "<e2>", "described", "."], "h": {"id": "C0059181", "name": "C0059181#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704693", "name": "C1704693#ent", "pos": [14, 15]}}
{"token": ["The", "high", "levels", "of", "Lp(a)", "C1704321#ent", "<e1>", "potentially", "cause", "glomerular", "injury", "well", "as", "increase", "the", "risk", "of", "C0003850#ent", "<e2>", "and", "thrombotic", "events", "associated", "with", "disorder", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [17, 18]}}
{"token": ["In", "our", "study", ",", "we", "found", "C4288963#ent", "<e1>", "trigger", "DNA", "damage", "by", "both", "C3711796#ent", "<e2>", "ATM", ")", "and", "ATM-", "and", "Rad3-related", "(", "ATR", ")", "pathways", "."], "h": {"id": "C4288963", "name": "C4288963#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3711796", "name": "C3711796#ent", "pos": [13, 14]}}
{"token": ["The", "C3541394#ent", "<e1>", "encoded", "by", "the", "C1414865#ent", "<e2>", "and", "FUT9", "genes", "are", "the", "first", "alpha3-fucosyltransferases", "strongly", "expressed", "during", "the", "first", "two", "months", "of", "embryogenesis", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414865", "name": "C1414865#ent", "pos": [6, 7]}}
{"token": ["One", "of", "the", "C3541394#ent", "<e1>", "responsible", "for", "the", "production", "of", "selectin", "ligands", "C1414865#ent", "<e2>", "FUT4", ")", ",", "a", "member", "of", "alpha1,3", "fucosyltransferases"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414865", "name": "C1414865#ent", "pos": [12, 13]}}
{"token": ["The", "inhibition", "by", "C0031493#ent", "<e1>", "prevented", "by", "C0012789#ent", "<e2>", ",", "and", "alpha", "1-antitrypsin", "soybean", "trypsin", "inhibitor", "did", "not", "inhibit", "."], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [7, 8]}}
{"token": ["This", "thrombin-like", "enzyme", "inhibited", "by", "C0031493#ent", "<e1>", "p-APMSF", ")", ",", "and", "dithiothreitol", "(", "C0012789#ent", "<e2>", ")", "suggesting", "that", "serines", "and", "disulfide", "bonds", "involved", "in", "the", "expression", "of", "the", "enzyme", "'s", "clotting", "activity"], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [13, 14]}}
{"token": ["The", "ongoing", "randomised", "trials", ",", "such", "as", "GUSTO-2", "and", "TIMI-9", ",", "will", "provide", "relevant", "information", "on", "the", "use", "of", "C0004057#ent", "<e1>", "plus", "heparin", "or", "C0004057#ent", "<e1>", "plus", "C1451270#ent", "<e1>", "in", "patients", "treated", "with", "thrombolytic", "therapy"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1451270", "name": "C1451270#ent", "pos": [27, 28]}}
{"token": ["Four", "antithrombotic", "drugs", "studied", ":", "two", "antiplatelet", "agents", "C0004057#ent", "<e1>", "and", "clopidogrel", ";", "two", "anticoagulants", ",", "heparin", "and", "recombinant", "C1451270#ent", "<e2>", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1451270", "name": "C1451270#ent", "pos": [19, 20]}}
{"token": ["This", "increase", "was", "unaffected", "by", "acetyl", "salicylic", "acid", "C0004057#ent", "<e1>", ")", ",", "apyrase", ",", "and", "C1451270#ent", "<e2>", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1451270", "name": "C1451270#ent", "pos": [15, 16]}}
{"token": ["Spermatozoa", "from", "nine", "asthenozoospermic", "patients", "were", "incubated", "for", "3", "h", "in", "Krebs", "Phosphate", "Ringer", "(", "C1334539#ent", "<e1>", ")", ",", "supplemented", "or", "not", "with", "17", "C0014914#ent", "<e2>", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014914", "name": "C0014914#ent", "pos": [24, 25]}}
{"token": ["These", "results", "indicate", "that", "C3539578#ent", "<e1>", ",", "a", "member", "of", "the", "EDG", "C0872043#ent", "<e2>", "is", "a", "specific", ",", "high-affinity", "SP", "receptor"], "h": {"id": "C3539578", "name": "C3539578#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0872043", "name": "C0872043#ent", "pos": [12, 13]}}
{"token": ["C0812382#ent", "<e1>", "functional", "NF-kappaB-binding", "sites", "and", "chromatin", "immunoprecipitation", "C0057856#ent", "<e2>", ")", "data", "showed", "binding", "of", "Rel", "to", "the", "endogenous", "blnk", "and", "bcap", "promoters", "in", "vivo"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0057856", "name": "C0057856#ent", "pos": [8, 9]}}
{"token": ["Our", "C3540471#ent", "<e1>", "was", "to", "investigate", "whether", "neurological", "impairment", "C0004943#ent", "<e2>", "BD", ")", "can", "be", "assessed", "by", "means", "of", "proton", "MRS", "and", "whether", "it", "can", "assist", "in", "prognosis", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [9, 10]}}
{"token": ["Our", "patient", "presented", "with", "C0270790#ent", "<e1>", "and", "pseudobalbur", "palsy", "not", "with", "C0023944#ent", "<e2>", "probably", "because", "the", "area", "of", "infarction", "limited", "within", "almost", "lateral", "portion", "peduncle", "."], "h": {"id": "C0270790", "name": "C0270790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023944", "name": "C0023944#ent", "pos": [11, 12]}}
{"token": ["Clinical", "features", "usually", "reflect", "damage", "to", "the", "descending", "motor", "tracts", "include", "C0270790#ent", "<e1>", "pseudobulbar", "paralysis", "and", "the", "C0023944#ent", "<e2>"], "h": {"id": "C0270790", "name": "C0270790#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023944", "name": "C0023944#ent", "pos": [17, 18]}}
{"token": ["There", "was", "an", "average", "of", "about", "1.3", "times", "more", "C1422118#ent", "<e1>", "in", "the", "bound", "form", "compared", "with", "extractable", "C1422118#ent", "<e1>", ",", "and", "this", "was", "about", "twice", "as", "much", "as", "C3275240#ent", "<e1>"], "h": {"id": "C1422118", "name": "C1422118#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3275240", "name": "C3275240#ent", "pos": [29, 30]}}
{"token": ["Resistance", "to", "thyroid", "hormone", "RTH", ")", "is", "a", "rare", "inherited", "C2936904#ent", "<e1>", "by", "mutations", "in", "the", "C0242988#ent", "<e2>", "TRb", ")", "gene", "."], "h": {"id": "C2936904", "name": "C2936904#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242988", "name": "C0242988#ent", "pos": [16, 17]}}
{"token": ["Women", "who", "undertake", "pregnancy", "with", "a", "C0022658#ent", "<e1>", "most", "commonly", "glomerulonephritis", "or", "C3495566#ent", "<e2>", "have", "a", "higher", "risk", "of", "adverse", "fetal", "and", "maternal", "outcomes", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C3495566", "name": "C3495566#ent", "pos": [12, 13]}}
{"token": ["The", "chronic", "sclerosing", "C0022658#ent", "<e1>", "from", "acute", "interstitial", "nephritis", "dealt", "with", ",", "as", "also", "are", "C3495566#ent", "<e2>", "incomplete", "obstructive", "nephropathy", "analgesic", "nephropathy", "and", "chronic", "interstitial", "rejection", "reactions", "in", "transplanted", "kidneys", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C3495566", "name": "C3495566#ent", "pos": [15, 16]}}
{"token": ["To", "evaluate", "endocrine", "effects", "C1334091#ent", "<e1>", "on", "bone", "growth", "we", "measured", "skeletal", "dimensions", "of", "12-week-old", "transgenic", "mice", "fusion", "genes", "a", "human", "C1334091#ent", "<e1>", "cDNA", "is", "transcriptionally", "controlled", "rat", "phospheonolpyruvate", "carboxykinase", "C0031644#ent", "<e1>", ")", "promoter", "sequences"], "h": {"id": "C1334091", "name": "C1334091#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [30, 31]}}
{"token": ["Among", "the", "test", "compounds", ",", "ketoconazole", "inhibited", "C1142644#ent", "<e1>", "activity", "most", "extensively", ",", "followed", "by", "C0025942#ent", "<e2>", ",", "troleandomycin", ",", "terfenazine", "and", "midazolam", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [15, 16]}}
{"token": ["This", "effect", "does", "not", "result", "from", "a", "direct", "inhibition", "of", "the", "gamma-secretase", "activity", "is", "specific", "for", "C1364818#ent", "<e1>", "cleavage", ",", "since", "C3540573#ent", "<e2>", "1864", "does", "not", "affect", "Notch", "cleavage"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540573", "name": "C3540573#ent", "pos": [21, 22]}}
{"token": ["This", "was", "a", "cephalometric", "study", "of", "maxillary", "growth", "LeFort", "III", "osteotomy", "children", "with", "C1333542#ent", "<e1>", ",", "Apert", ",", "and", "C1333542#ent", "<e1>", "(", "CAP", ")", "syndromes", "."], "h": {"id": "C1333542", "name": "C1333542#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333542", "name": "C1333542#ent", "pos": [13, 14]}}
{"token": ["Ten", "infants", "and", "children", "who", "presented", "with", "craniofacial", "dysostosis", "discussed", ";", "four", "had", "Apert's", "syndrome", "four", "had", "C1333542#ent", "<e1>", "one", "had", "C1333542#ent", "<e1>", "and", "one", "had", "hypertelorism", "."], "h": {"id": "C1333542", "name": "C1333542#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333542", "name": "C1333542#ent", "pos": [17, 18]}}
{"token": ["Efavirenz", "(", "C0674428#ent", "<e1>", ")", "and", "nevirapine", "(", "NVP", ")", "are", "metabolized", "by", "C0534137#ent", "<e2>", "CYP2B6", ")", "."], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [13, 14]}}
{"token": ["C1427198#ent", "<e1>", "returned", "to", "control", "values", "after", "volume", "repletion", "orally", "administered", "C3811061#ent", "<e2>", "solution", "and", "averaged", "4.3", "+", "/-", "0.3", "nl/min", "."], "h": {"id": "C1427198", "name": "C1427198#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3811061", "name": "C3811061#ent", "pos": [11, 12]}}
{"token": ["Reverse", "transcriptase-polymerase", "chain", "reaction", "RT-PCR", ")", "and", "Southern", "blot", "analysis", "a", "C3276534#ent", "<e1>", "fusion", "transcript", "and", "C1334538#ent", "<e2>", "rearrangement", ",", "respectively", ",", "in", "all", "three", "cases", "."], "h": {"id": "C3276534", "name": "C3276534#ent", "pos": [11, 12]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1334538", "name": "C1334538#ent", "pos": [16, 17]}}
{"token": ["C0700450#ent", "<e1>", "as", "a", "predominant", "C2987634#ent", "<e2>", "increases", "heart", "rate", "myocardial", "contractility", "at", "sufficient", "high", "doses", "it", "also", "increases", "systolic", "blood", "pressure"], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}}
{"token": ["C0700450#ent", "<e1>", "was", "a", "full", "beta", "adrenoceptor", "C2987634#ent", "<e2>", "in", "guinea-pig", "trachea", "spontaneous", "tone", "a", "partial", "C2987634#ent", "<e2>", "after", "strong", "contraction", "by", "bethanechol", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}}
{"token": ["There", "was", "no", "significant", "in", "the", "VP", "of", "this", "group", "when", "compared", "with", "79", "children", "with", "C0042075#ent", "<e1>", "(", "group", "IB=47", "enuretic", ",", "19", "C0042580#ent", "<e2>", "13", "urinary", "tract", "infection", "."], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0042580", "name": "C0042580#ent", "pos": [24, 25]}}
{"token": ["The", "C3537142#ent", "<e1>", "actions", "of", "low", "and", "high", "doses", "C0147448#ent", "<e2>", ",", "a", "selective", "kappa-receptor", "agonist", ",", "were", "examined", "in", "pentobarbitone-anaesthetized", "rats", "subjected", "to", "occlusion", "of", "the", "left", "anterior", "descending", "coronary", "artery"], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0147448", "name": "C0147448#ent", "pos": [9, 10]}}
{"token": ["C0002555#ent", "<e1>", "genotypes", "or", "haplotypes", "were", "not", "related", "to", "hypertension", ",", "C1956346#ent", "<e2>", "or", "MI", "."], "h": {"id": "C0002555", "name": "C0002555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}}
{"token": ["We", "recently", "identified", "a", "polymorphism", "in", "exon", "6", "A138", "G", ")", "of", "the", "gene", "encoding", "C1335285#ent", "<e1>", "(", "C1870006#ent", "<e2>", ")", "that", "results", "in", "altered", "C1335285#ent", "<e1>", "splicing", "."], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335285", "name": "C1335285#ent", "pos": [15, 16]}}
{"token": ["Different", "monoclonal", "antibodies", "the", "leucocyte", "common", "antigen", "have", "been", "obtained", ",", "for", "C1870006#ent", "<e1>", "(", "GRT2", ",", "GRT3", "and", "GRT4", ")", "and", "for", "C1335285#ent", "<e2>", "(", "GRT22", ")", "."], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335285", "name": "C1335285#ent", "pos": [23, 24]}}
{"token": ["Although", "oral", "griseofulvin", "has", "been", "the", "standard", "treatment", "C0040250#ent", "<e1>", "newer", "oral", "antifungal", "agents", "as", "C0076110#ent", "<e2>", ",", "itraconazole", ",", "and", "fluconazole", "are", "effective", ",", "safe", ",", "and", "have", "shorter", "treatment", "courses", "."], "h": {"id": "C0040250", "name": "C0040250#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [15, 16]}}
{"token": ["Treatment", "of", "C0040250#ent", "<e1>", "fluconazole", ",", "itraconazole", ",", "and", "C0076110#ent", "<e2>", ",", "antibiotic", "therapy", "staphylococcal", "skin", "infections", "cidofovir", "for", "the", "treatment", "of", "verrucae", "vulgaris", "molluscum", "contagiosum", "ivermectin", "for", "scabies", "and", "head", "lice", "discussed", "."], "h": {"id": "C0040250", "name": "C0040250#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [9, 10]}}
{"token": ["Chromosomal", "localization", "that", "mouse", "C1424587#ent", "<e1>", "mapped", "to", "mouse", "chromosome", "16", ",", "in", "a", "region", "highly", "C1334043#ent", "<e2>", "with", "the", "area", "on", "which", "human", "C1424587#ent", "<e1>", "was", "previously", "located", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1424587", "name": "C1424587#ent", "pos": [4, 5]}}
{"token": ["Tissue", "distribution", "studies", "indicated", "significant", "binding", "differences", "both", "within", "and", "among", "various", "tissues", "in", "C2987364#ent", "<e1>", ",", "ERalphaKO", ",", "and", "C1366496#ent", "<e2>", "knockout", "female", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1366496", "name": "C1366496#ent", "pos": [20, 21]}}
{"token": ["There", "have", "been", "mixed", "reports", "regarding", "the", "effectiveness", "of", "topical", "treatments", "which", "include", "selenium", "sulfide", "C0022625#ent", "<e1>", "tretinoin", ",", "tazarotene", ",", "tacalcitol", ",", "and", "C0065767#ent", "<e2>", "(", "calcipotriol", ")", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0065767", "name": "C0065767#ent", "pos": [24, 25]}}
{"token": ["Erythropoietin", "(", "C1414438#ent", "<e1>", ")", "is", "the", "crucial", "C1418870#ent", "<e2>", "red", "blood-cell", "production", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418870", "name": "C1418870#ent", "pos": [8, 9]}}
{"token": ["The", "C0024518#ent", "<e1>", "MHC", ")", "genes", "including", "C0812246#ent", "<e2>", ",", "HSP70", "and", "HLA", "genes", "been", "associated", "with", "systemic", "lupus", "erythematosus", "SLE", ")", "in", "several", "populations", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "N-acetyl-l-cysteine", ",", "a", "reducing", "supplier", ",", "completely", "inhibited", "the", "DNCB-induced", "expression", "of", "C0024518#ent", "<e1>", "and", "costimulatory", "molecules", "but", "not", "those", "induced", "by", "C0812246#ent", "<e2>", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [25, 26]}}
{"token": ["It", "was", "more", "effective", "than", "oral", "meclizine", "or", "C0008803#ent", "<e1>", ",", "similar", "to", "oral", "C0036442#ent", "<e2>", "0.6", "mg", "or", "promethazine", "plus", "ephedrine", ",", "and", "the", "same", "as", "or", "superior", "to", "dimenhydrinate", "."], "h": {"id": "C0008803", "name": "C0008803#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [14, 15]}}
{"token": ["These", "results", ",", "taken", "in", "conjunction", "with", "previous", "trials", ",", "suggest", "that", "oral", "C0008803#ent", "<e1>", "would", "seem", "less", "likely", "than", "C0036442#ent", "<e2>", "to", "produce", "unwanted", "decrements", "in", "performance", "."], "h": {"id": "C0008803", "name": "C0008803#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [20, 21]}}
{"token": ["In", "mild", "motion", "C0008803#ent", "<e1>", "was", "better", "tolerated", "than", "C0036442#ent", "<e2>", "in", "having", "less", "marked", "side", "effects"], "h": {"id": "C0008803", "name": "C0008803#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [9, 10]}}
{"token": ["This", "study", "has", "two", "aims", ";", "to", "determine", "the", "incidence", "of", "severe", "persistent", "GH", "deficiency", "treatment", "of", "C0271725#ent", "<e1>", "to", "assess", "the", "time", "scale", "any", "recovery", "of", "C3539616#ent", "<e2>", "secretory", "status", "surgical", "cure", "C0271725#ent", "<e1>"], "h": {"id": "C0271725", "name": "C0271725#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "following", "cure", "of", "C0271725#ent", "<e1>", "resolution", "of", "hypercortisolaemia", ",", "recovery", "of", "C3539616#ent", "<e2>", "secretory", "status", "seen", ",", "thus", "creating", "uncertainty", "as", "to", "the", "persistence", "of", "any", "documented", "GH", "deficiency"], "h": {"id": "C0271725", "name": "C0271725#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [13, 14]}}
{"token": ["Interestingly", ",", "in", "C0271725#ent", "<e1>", "ghrelin", "markedly", "increases", "plasma", "ACTH", ",", "whereas", "its", "stimulatory", "action", "C3539616#ent", "<e2>", "secretion", "is", "reduced", "."], "h": {"id": "C0271725", "name": "C0271725#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [15, 16]}}
{"token": ["To", "compare", "ecabet", "sodium", "C0008783#ent", "<e1>", "in", "relieving", "symptoms", "of", "functional", "C0013395#ent", "<e2>", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [11, 12]}}
{"token": ["Vasoinhibitory", "effects", "of", "(-)-(S)-2-[3,5-bis(1", ",", "1-dimethylethyl)-4-hydroxyphenyl]-3-[3-[N-methyl-N-[2-(3", ",", "4-methylenedioxyphenoxy)ethyl]amino]propyl]-1,3-thiazolidin-", "4-one", "hydrogen", "fumarate", "C0536609#ent", "<e1>", ")", ",", "a", "synthesized", "C0007209#ent", "<e2>", "were", "examined", "."], "h": {"id": "C0536609", "name": "C0536609#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [17, 18]}}
{"token": ["C0275524#ent", "<e1>", "of", "EP-cadherin", "RNA", "but", "also", "C0694872#ent", "<e2>", "rescued", "the", "disaggregated", "phenotype", "."], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [7, 8]}}
{"token": ["Accordingly", ",", "C0812244#ent", "<e1>", "decayed", "at", "faster", "rates", "in", "the", "absence", "of", "C1539660#ent", "<e2>", "than", "in", "its", "presence", "."], "h": {"id": "C0812244", "name": "C0812244#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539660", "name": "C1539660#ent", "pos": [12, 13]}}
{"token": ["In", "secretory", "diarrhea", "by", "phenolphthalein", ",", "the", "osmotic", "gap", "always", "less", "than", "50", "mOsm/kg", ",", "whereas", "in", "C0267556#ent", "<e1>", "by", "polyethylene", "glycol", "magnesium", "hydroxide", "lactulose", ",", "and", "C0037688#ent", "<e2>", ",", "the", "osmotic", "gap", "exceeded", "50", "mOsm/kg", "."], "h": {"id": "C0267556", "name": "C0267556#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [27, 28]}}
{"token": ["Finally", ",", "some", "examples", "of", "unwise", "regulatory", "decisions", "C0036023#ent", "<e1>", ",", "spray", "adhesives", "Depo-Provera", ",", "and", "a", "new", "C0003376#ent", "<e2>", "are", "given", "."], "h": {"id": "C0036023", "name": "C0036023#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003376", "name": "C0003376#ent", "pos": [18, 19]}}
{"token": ["Expression", "analysis", "that", "Fox1", "and", "Ftrl", "were", "coordinately", "induced", "by", "C0240066#ent", "<e1>", "as", "were", "Atx1", "and", "C1418464#ent", "<e2>", ",", "although", "to", "lesser", "extents"], "h": {"id": "C0240066", "name": "C0240066#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418464", "name": "C1418464#ent", "pos": [16, 17]}}
{"token": ["A", "number", "of", "protease", "inhibitors", "ineffective", "in", "preventing", "the", "C1321914#ent", "<e1>", "morphological", "changes", ";", "these", "include", "inhibitors", "of", "C0960371#ent", "<e2>", ",", "chymotrypsin", ",", "elastase", ",", "thrombin", "and", ",", "most", "importantly", ",", "plasmin", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [18, 19]}}
{"token": ["C0007384#ent", "<e1>", "improved", "when", "C0032912#ent", "<e2>", "was", "discontinued", "."], "h": {"id": "C0007384", "name": "C0007384#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [4, 5]}}
{"token": ["The", "membrane-anchored", "aspartyl", "protease", "beta-site", "APP-cleaving", "enzyme", "(", "BACE", ")", "exhibits", "all", "of", "the", "characteristics", "of", "a", "C1569775#ent", "<e1>", "and", "has", "been", "shown", "to", "cleave", "C1364818#ent", "<e2>", "at", "its", "beta-site", "in", "vitro", "in", "vivo"], "h": {"id": "C1569775", "name": "C1569775#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [25, 26]}}
{"token": ["Memapsin", "2", "or", "beta-secretase", ",", "is", "a", "C1569775#ent", "<e1>", "initiates", "the", "cleavage", "of", "C1364818#ent", "<e2>", "APP", ")", "leading", "to", "the", "production", "of", "beta-amyloid", "peptide", "the", "brain", "and", "the", "onset", "of", "Alzheimer's", "disease"], "h": {"id": "C1569775", "name": "C1569775#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [13, 14]}}
{"token": ["The", "synthetic", "flavone", "C0281603#ent", "<e1>", "can", "be", "C0010858#ent", "<e2>", "or", "cytotoxic", "to", "mammalian", "cells", "depending", "on", "the", "concentration", "of", "the", "drug", "and", "the", "duration", "of", "exposure", "."], "h": {"id": "C0281603", "name": "C0281603#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [7, 8]}}
{"token": ["However", ",", "when", "administered", "as", "a", "single", "agent", "solid", "tumors", "the", "antitumor", "actions", "C0281603#ent", "<e1>", "have", "been", "primarily", "C0010858#ent", "<e2>", "."], "h": {"id": "C0281603", "name": "C0281603#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [18, 19]}}
{"token": ["The", "new", "antiepileptic", "drugs", ",", "gabapentin", ",", "lamotrigine", ",", "C0068897#ent", "<e1>", ",", "topiramate", ",", "vigabatrin", "and", "C0069751#ent", "<e2>", "demonstrated", "superior", "efficacy", "for", "some", "with", "refractory", "epilepsy", "."], "h": {"id": "C0068897", "name": "C0068897#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0069751", "name": "C0069751#ent", "pos": [16, 17]}}
{"token": ["This", "review", "article", "the", "newer", "anti-epileptic", "drugs", "gabapentin", ",", "lamotrigine", ",", "C0068897#ent", "<e1>", ",", "topiramate", ",", "levetiracetam", ",", "C0069751#ent", "<e2>", ",", "and", "zonisamide", "."], "h": {"id": "C0068897", "name": "C0068897#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0069751", "name": "C0069751#ent", "pos": [18, 19]}}
{"token": ["Congenital", "disorders", "glycosylation", ",", "formerly", "called", "C0349653#ent", "<e1>", "may", "present", "in", "infancy", "with", "slowly", "progressive", "neurologic", "deficits", "cognitive", "impairment", "C0004134#ent", "<e2>", ",", "pigmentary", "retinal", "degeneration", "and", "neuropathy", "."], "h": {"id": "C0349653", "name": "C0349653#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [19, 20]}}
{"token": ["C0349653#ent", "<e1>", "characterized", "by", "mental", "retardation", "C0004134#ent", "<e2>", ",", "hepatopathy", "during", "infancy", ",", "cerebellar", "hypoplasia", "peripheral", "neuropathy", "internal", "strabismus", "growth", "retardation", "stroke-like", "episodes"], "h": {"id": "C0349653", "name": "C0349653#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [6, 7]}}
{"token": ["Subacute", "necrotising", "encephalomyopathy", "C0023264#ent", "<e1>", "due", "to", "C1537985#ent", "<e2>", "COX", ")", "deficiency", "is", "often", "caused", "by", "mutations", "in", "the", "SURF1", "gene", "encoding", "the", "Surf1", "protein", "for", "COX", "assembly", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [7, 8]}}
{"token": ["A", "functional", "homologue", "C1421361#ent", "<e1>", ")", "of", "the", "human", "uracil-DNA-glycosylase", "UNG", ")", "C0079429#ent", "<e2>", "was", "characterized", "from", "fission", "yeast", "Schizosaccharomyces", "pombe", "."], "h": {"id": "C1421361", "name": "C1421361#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}}
{"token": ["1-Anilino-8-naphthalenesulfonate", "binding", "measurements", "and", "an", "enhanced", "susceptibility", "to", "C0041236#ent", "<e1>", "supported", "the", "supposition", "that", "chemical", "modification", "transformed", "native", "C0001044#ent", "<e2>", "to", "a", "\"", "molten", "globule", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001044", "name": "C0001044#ent", "pos": [18, 19]}}
{"token": ["C0751651#ent", "<e1>", "manifest", "as", "C0442893#ent", "<e2>", "muscular", "fatigue"], "h": {"id": "C0751651", "name": "C0751651#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [4, 5]}}
{"token": ["C0023660#ent", "<e1>", "is", "metabolized", "by", "C1142644#ent", "<e2>", "CYP3A4", ")", ",", "and", "has", "a", "moderate", "to", "high", "extraction", "ratio", "resulting", "in", "oral", "bioavailability", "30", "%", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [5, 6]}}
{"token": ["C0023660#ent", "<e1>", ")", "as", "a", "marker", "of", "C1142644#ent", "<e2>", "activity", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [7, 8]}}
{"token": ["We", "recently", "identified", "a", "synthetic", "peptide", "Pro47-Ile58", ",", "derived", "from", "the", "mature", "C0085151#ent", "<e1>", "PN1", ")", "sequence", ",", "that", "inhibited", "the", "C1416914#ent", "<e2>", "internalization", "of", "thrombin-PN1", "(", "Th-PN1", ")", "complexes", "."], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416914", "name": "C1416914#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "our", "recent", "work", "has", "demonstrated", "that", "C2985427#ent", "<e1>", "presents", "relatively", "long", "C0030956#ent", "<e2>", "with", "a", "structured", "motif", "distinct", "from", "classical", "class", "I", "molecules"], "h": {"id": "C2985427", "name": "C2985427#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}}
{"token": ["This", "C0037039#ent", "<e1>", "similar", "to", "that", "of", "previously", "cloned", "C0257149#ent", "<e2>", "chicken", "and", "mouse", ")", "and", "shows", "the", "sialylmotifs", "that", "are", "present", "in", "all", "eukaryotic", "members", "the", "sialyltransferase", "gene", "family"], "h": {"id": "C0037039", "name": "C0037039#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0257149", "name": "C0257149#ent", "pos": [9, 10]}}
{"token": ["C0015230#ent", "<e1>", "or", "elevation", "of", "GOT", "and", "C1415274#ent", "<e2>", "were", "noticed", "in", "3", "patients", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415274", "name": "C1415274#ent", "pos": [7, 8]}}
{"token": ["Adverse", "effects", "C0015230#ent", "<e1>", "1", "case", ",", "and", "increased", "GOT", "and", "C1415274#ent", "<e2>", "in", "1", "case", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415274", "name": "C1415274#ent", "pos": [11, 12]}}
{"token": ["Monoamine", "oxidase", "MAO", ")", "and", "catechol-o-methyl", "transferase", "COMT", ")", "activities", "have", "been", "measured", "in", "fibroblasts", "from", "nine", "healthy", "controls", "three", "patients", "with", "maple", "syrup", "C0037933#ent", "<e1>", "MSUD", ")", "and", "six", "patients", "with", "C0023374#ent", "<e2>"], "h": {"id": "C0037933", "name": "C0037933#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [32, 33]}}
{"token": ["Among", "the", "dCTP", "analogues", "tested", ",", "2'-azido-2',3'-dideoxy", "CTP", "inhibited", "C1335494#ent", "<e1>", "strongly", "and", "C0035681#ent", "<e2>", "II", "to", "lesser", "extent", "."], "h": {"id": "C1335494", "name": "C1335494#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [13, 14]}}
{"token": ["The", "C1335494#ent", "<e1>", "from", "bacteriophage", "T4", "a", "C0035681#ent", "<e2>", "is", "one", "of", "the", "seven", "proteins", "that", "constitute", "the", "DNA-replication", "machinery", "of", "bacteriophage", "T4"], "h": {"id": "C1335494", "name": "C1335494#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [7, 8]}}
{"token": ["Although", "P.", "aeruginosa", "found", "to", "have", "proteins", "similar", "to", "the", "enteric", "chemotaxis", "proteins", ",", "C0048979#ent", "<e1>", ",", "CheW", ",", "CheY", ",", "and", "CheZ", ",", "the", "C0017337#ent", "<e2>", "encoding", "a", "CheR", "homologue", "not", "reside", "in", "the", "chemotaxis", "gene", "cluster"], "h": {"id": "C0048979", "name": "C0048979#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [25, 26]}}
{"token": ["The", "ligand", "binding", "effectively", "displaced", "by", "BQ123", ",", "a", "selective", "antagonist", "for", "C1414262#ent", "<e1>", "but", "not", "by", "S6c", ",", "a", "selective", "ligand", "for", "C1414263#ent", "<e2>", "in", "both", "control", "and", "angiotensin", "II-treated", "cells", "."], "h": {"id": "C1414262", "name": "C1414262#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414263", "name": "C1414263#ent", "pos": [23, 24]}}
{"token": ["We", "have", "investigated", "the", "role", "of", "NAADP-mediated", "Ca(2+)", "mobilization", "in", "endothelin", "(", "ET", ")", "signaling", "via", "C1414262#ent", "<e1>", "ETA", ")", "and", "C1414263#ent", "<e2>", "ETB", ")", "in", "rat", "peritubular", "smooth", "muscle", "cells"], "h": {"id": "C1414262", "name": "C1414262#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1414263", "name": "C1414263#ent", "pos": [21, 22]}}
{"token": ["Primary", "(", "hereditary", ")", "hemochromatosis", "was", "diagnosed", "as", "the", "pathological", "background", "of", "C0011847#ent", "<e1>", "as", "well", "as", "the", "C0521989#ent", "<e2>", "weight", "loss", "arthrosis", ",", "erectile", "dysfunction", "supraventricular", "arrhythmia", "hepatic", "cirrhosis", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0521989", "name": "C0521989#ent", "pos": [18, 19]}}
{"token": ["Fourteen", "slightly", "disabled", "patients", "with", "C0030567#ent", "<e1>", "were", "treated", "separately", "with", "C0041009#ent", "<e2>", ",", "amantadine", ",", "and", "levodopa", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0041009", "name": "C0041009#ent", "pos": [11, 12]}}
{"token": ["To", "introduce", "a", "protocol", "for", "dissociative", "sedation", "C0700541#ent", "<e1>", "for", "children", "requiring", "C0030193#ent", "<e2>", "the", "emergency", "department"], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}}
{"token": ["DXR", "is", "the", "key", "C0027203#ent", "<e1>", "in", "the", "2-C-methyl-D-erythritol", "4-phosphate", "pathway", "is", "an", "effective", "target", "of", "C0242911#ent", "<e2>", "as", "fosmidomycin", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242911", "name": "C0242911#ent", "pos": [16, 17]}}
{"token": ["Further", "characterization", "of", "the", "C0027203#ent", "<e1>", "may", "lead", "to", "the", "development", "of", "novel", "C0242911#ent", "<e2>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242911", "name": "C0242911#ent", "pos": [13, 14]}}
{"token": ["Genistein", "inhibits", "estrogen", "receptor-alpha", "activates", "BARD1", "in", "C1704743#ent", "<e1>", "blocked", "cells", "and", "induces", "C1414462#ent", "<e2>", "FAS", "in", "presence", "of", "C1704743#ent", "<e1>", "."], "h": {"id": "C1704743", "name": "C1704743#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414462", "name": "C1414462#ent", "pos": [13, 14]}}
{"token": ["Human", "VAP-C", "was", "a", "splicing", "variant", "C1421425#ent", "<e1>", ",", "lacking", "both", "the", "coiled-coil", "domain", "the", "C1838244#ent", "<e2>", "."], "h": {"id": "C1421425", "name": "C1421425#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1838244", "name": "C1838244#ent", "pos": [15, 16]}}
{"token": ["However", ",", "both", "C2987048#ent", "<e1>", "41", "-", "0960", "and", "quercetin", "caused", "a", "decrease", "of", "C0046319#ent", "<e2>", "formation", "and", "an", "increase", "of", "catechol", "estrogen-induced", "DNA", "damage", "MCF-7", "cells"], "h": {"id": "C2987048", "name": "C2987048#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0046319", "name": "C0046319#ent", "pos": [14, 15]}}
{"token": ["In", "controls", ",", "C0268731#ent", "<e1>", "greater", "with", "increasing", "severity", "of", "C0015695#ent", "<e2>", "probably", "as", "a", "reflection", "of", "obesity", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015695", "name": "C0015695#ent", "pos": [10, 11]}}
{"token": ["While", "VEGF", "by", "stimulating", "angiogenesis", "plays", "a", "key", "role", "in", "new", "bone", "formation", "C0015302#ent", "<e1>", ",", "increase", "of", "C2001899#ent", "<e2>", "and", "-9", "is", "instrumental", "for", "cartilage", "erosion", "the", "pathogenesis", "of", "OA", "."], "h": {"id": "C0015302", "name": "C0015302#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [18, 19]}}
{"token": ["Specifically", ",", "p16ink4a", "disrupts", "prereplication", "complex", "assembly", "by", "inhibiting", "mini-chromosome", "maintenance", "(", "MCM", ")", "protein", "loading", "G1", ",", "while", "C0694889#ent", "<e1>", "was", "found", "to", "disrupt", "replication", "in", "S", "phase", "attenuation", "of", "C1366837#ent", "<e2>", "function", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [31, 32]}}
{"token": ["Abundant", "p21", "protein", "expression", "resulted", "in", "hypophosphorylation", "of", "the", "retinoblastoma", "protein", "C0694889#ent", "<e1>", ")", "and", "inhibition", "of", "the", "proliferating", "cell", "nuclear", "antigen", "C1366837#ent", "<e2>", ")", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [22, 23]}}
{"token": ["Abundant", "p21", "protein", "expression", "resulted", "in", "hypophosphorylation", "of", "the", "retinoblastoma", "protein", "C0694889#ent", "<e1>", ")", "and", "inhibition", "of", "the", "C1366837#ent", "<e2>", "PCNA", ")", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [18, 19]}}
{"token": ["Male", "transgenic", "mice", "carry", "a", "construct", "containing", "5'-flanking", "sequences", "the", "C1413844#ent", "<e1>", "to", "the", "early", "region", "the", "simian", "virus", "40", "C1456377#ent", "<e2>", ")", "genome", "reproducibly", "develop", "tumors", "arising", "from", "the", "prostate", "gland"], "h": {"id": "C1413844", "name": "C1413844#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [20, 21]}}
{"token": ["Signalling", "through", "the", "C1366515#ent", "<e1>", "been", "shown", "to", "activate", "the", "SH2", "domain-containing", "tyrosine", "phosphatase", "C1566685#ent", "<e2>", "through", "tyrosine", "phosphorylation"], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1566685", "name": "C1566685#ent", "pos": [14, 15]}}
{"token": ["Genomic", "C0011522#ent", "<e1>", "encoding", "the", "horseradish", "peroxidase", "HRP", ")", "C0022173#ent", "<e2>", ",", "prxC2", "and", "prxC3", ",", "were", "cloned", "and", "sequenced", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [9, 10]}}
{"token": ["The", "SERT", "inhibitor-induced", "increase", "in", "C1826724#ent", "<e1>", "was", "unaffected", "by", "pretreatment", "with", "C0030135#ent", "<e2>", "but", "was", "inhibited", "by", "calcium", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [12, 13]}}
{"token": ["Epileptic", "syndrome", "presented", "with", "generalized", "seizures", "grand", "mal", "6", "cases", ",", "C4023512#ent", "<e1>", "13", "cases", ")", "and", "C0752324#ent", "<e2>", "simple", "motor", "--", "2", "cases", ")", "."], "h": {"id": "C4023512", "name": "C4023512#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0752324", "name": "C0752324#ent", "pos": [17, 18]}}
{"token": ["Group", "2", "30", "rats", ")", "was", "given", "C2698738#ent", "<e1>", "as", "in", "group", "1", "fed", "the", "basal", "diet", ",", "without", "C0056413#ent", "<e2>", "."], "h": {"id": "C2698738", "name": "C2698738#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0056413", "name": "C0056413#ent", "pos": [19, 20]}}
{"token": ["The", "C1704463#ent", "<e1>", "in", "CHO", "cells", "saturable", "binding", "of", "[125I]CYP", "(", "C1839259#ent", "<e2>", "=", "14.5", "pM", ")", "and", "stereospecificity", "for", "(-)-", "and", "(+)-isoproterenol", "."], "h": {"id": "C1704463", "name": "C1704463#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [11, 12]}}
{"token": ["The", "mean", "values", "of", "SBP", "and", "C1415740#ent", "<e1>", "and", "beta", "and", "PWV", ",", "the", "prevalence", "of", "C0751955#ent", "<e2>", "compared", "across", "these", "quartiles", "by", "means", "of", "analysis", "of", "variance", "chi-square", "test", "respectively", "."], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751955", "name": "C0751955#ent", "pos": [16, 17]}}
{"token": ["The", "reported", "side", "effects", "C0026964#ent", "<e1>", ",", "cycloplegics", ",", "benzodiazepines", ",", "tetracyclines", ",", "C0885449#ent", "<e2>", ",", "topical", "anesthetics", "medications", "used", "for", "hemostasis", ",", "nonsteroidal", "antiinflammatory", "drugs", "steroids", ",", "antibiotics", ",", "and", "artificial", "tears", "described", "."], "h": {"id": "C0026964", "name": "C0026964#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0885449", "name": "C0885449#ent", "pos": [13, 14]}}
{"token": ["A", "primary", "culture", "silver", "sea", "bream", "macrophages", "(", "C0075134#ent", "<e1>", ")", "displayed", "reduced", "C1415760#ent", "<e2>", ",", "underwent", "apoptosis", "and", "displayed", "reduced", "phagocytic", "activity", "exposure", "to", "cortisol", "."], "h": {"id": "C0075134", "name": "C0075134#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [13, 14]}}
{"token": ["These", "aneurysms", ",", "secondary", "to", "C0719022#ent", "<e1>", "contrast", "with", "infectious", "aneurysms", "so-called", "C0026946#ent", "<e2>", ")", "secondary", "to", "septic", "embols", "."], "h": {"id": "C0719022", "name": "C0719022#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [12, 13]}}
{"token": ["In", "properly", "selected", "cases", "(", "i.e.", "significant", "C0011168#ent", "<e1>", "and", "radiological", "proof", "of", "C0014852#ent", "<e2>", "cricopharyngeal", "myotomy", "complete", "or", "at", "least", "substantial", "relief", "of", "symptoms", "for", "three", "out", "of", "four", "patients", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0014852", "name": "C0014852#ent", "pos": [13, 14]}}
{"token": ["Cineradiographic", "examination", "300", "patients", "with", "unexplained", "C0011168#ent", "<e1>", "revealed", "57", "cases", "of", "C0014852#ent", "<e2>"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0014852", "name": "C0014852#ent", "pos": [12, 13]}}
{"token": ["C1823884#ent", "<e1>", "is", "the", "mouse", "ortholog", "of", "FRGY2", ",", "the", "Xenopus", "germ", "C1332420#ent", "<e2>", "the", "human", "germ", "cell", "protein", "Contrin", "."], "h": {"id": "C1823884", "name": "C1823884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332420", "name": "C1332420#ent", "pos": [12, 13]}}
{"token": ["These", "new", "mutations", "in", "the", "myelin", "P0", "connexin", "32", "C1417679#ent", "<e1>", "help", "to", "clarify", "the", "pathophysiology", "of", "the", "C0007959#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007959", "name": "C0007959#ent", "pos": [18, 19]}}
{"token": ["Complete", "dependence", "on", "the", "presence", "of", "Cl-", "ions", "and", "sensitivity", "to", "C0006376#ent", "<e1>", "confirmed", "that", "C0006945#ent", "<e2>", "induces", "Cl-", "secretion", "."], "h": {"id": "C0006376", "name": "C0006376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [15, 16]}}
{"token": ["Defective", "C1420307#ent", "<e1>", "signaling", "pathway", "and", "impaired", "expression", "of", "C0887942#ent", "<e2>", "were", "inextricably", "linked", "to", "the", "pathogenesis", "of", "Crohn's", "disease", "a", "common", "form", "of", "inflammatory", "bowel", "disease"], "h": {"id": "C1420307", "name": "C1420307#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0887942", "name": "C0887942#ent", "pos": [9, 10]}}
{"token": ["Tumor", "necrosis", "factor", "alpha", "C1710304#ent", "<e1>", ")", "is", "found", "to", "take", "part", "in", "systemic", "inflammation", "and", "C0812265#ent", "<e2>", "plays", "an", "important", "role", "in", "mucin", "hypersecretion", "of", "COPD", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812265", "name": "C0812265#ent", "pos": [16, 17]}}
{"token": ["Patients", "with", "C0950121#ent", "<e1>", "with", "early", "C0027726#ent", "<e2>", "diffuse", "mesangial", "sclerosis", "rapidly", "to", "end-stage", "renal", "failure", "male", "pseudohermaphroditism", "and", "Wilms'", "tumor"], "h": {"id": "C0950121", "name": "C0950121#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "C0968477#ent", "<e1>", ",", "the", "human", "C1334043#ent", "<e2>", "of", "a", "putative", "substrate", "of", "TSSK", "1", "and", "2", ",", "was", "cloned", "."], "h": {"id": "C0968477", "name": "C0968477#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}}
{"token": ["Since", "no", "electrocardiographic", "changes", "seen", "in", "conscious", "dogs", "during", "pauses", "in", "the", "C0751494#ent", "<e1>", "is", "concluded", "that", "C0008845#ent", "<e2>", "does", "not", "exert", "cardiotoxic", "effects", "the", "dog", "."], "h": {"id": "C0751494", "name": "C0751494#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008845", "name": "C0008845#ent", "pos": [17, 18]}}
{"token": ["Stimulatory", "effects", "C0034414#ent", "<e1>", "also", "were", "observed", "with", "recombinant", "C3714798#ent", "<e2>", ",", "suggesting", "that", "increases", "in", "warfarin", "metabolism", "were", "due", "to", "quinidine-mediated", "enhancement", "of", "C3714798#ent", "<e2>", "activity", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [9, 10]}}
{"token": ["C1387532#ent", "<e1>", "thrombocytopenia", ",", "and", "C0005779#ent", "<e2>", "due", "to", "folate", "deficiency", "mimic", "the", "syndrome", "of", "hemolysis", ",", "elevated", "liver", "enzymes", "and", "low", "platelets", "HELLP", ")", "."], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [5, 6]}}
{"token": ["In", "addition", "C1387532#ent", "<e1>", "posthaemolytic", "states", "as", "well", "as", "consumption", "C0005779#ent", "<e2>", "occur", "."], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [10, 11]}}
{"token": ["The", "RKK", ",", "C1384522#ent", "<e1>", ",", "and", "MAPKAP", "C0108555#ent", "<e2>", "constitute", "a", "new", "stress-activated", "signal", "transduction", "pathway", "vertebrates", "that", "is", "distinct", "from", "the", "classical", "MAPK", "cascade"], "h": {"id": "C1384522", "name": "C1384522#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0108555", "name": "C0108555#ent", "pos": [8, 9]}}
{"token": ["Numerical", "results", "obtained", "for", "the", "2003", "C1419818#ent", "<e1>", "outbreak", "in", "Taiwan", "and", "the", "C0058836#ent", "<e2>", "implications", "of", "time-varying", "transmission", "rates", "and", "scale-free", "contact", "networks", "are", "discussed", "in", "some", "detail", "."], "h": {"id": "C1419818", "name": "C1419818#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0058836", "name": "C0058836#ent", "pos": [13, 14]}}
{"token": ["Indeed", ",", "we", "found", "that", "C1420317#ent", "<e1>", "and", "C1455430#ent", "<e2>", "colocalized", "in", "early", "melanoblasts", "and", "that", "C1420317#ent", "<e1>", "is", "capable", "of", "transactivating", "the", "Dct", "promoter", "in", "vitro"], "h": {"id": "C1455430", "name": "C1455430#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420317", "name": "C1420317#ent", "pos": [5, 6]}}
{"token": ["We", "tested", "our", "system", "using", "a", "database", "of", "20", "C3540513#ent", "<e1>", "scans", "of", "patients", "with", "C0003486#ent", "<e2>"], "h": {"id": "C3540513", "name": "C3540513#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [15, 16]}}
{"token": ["Active", "MT1", "MT2", "and", "C1417205#ent", "<e1>", "levels", "were", "similar", "in", "all", "lines", ",", "but", "processed", "C1568288#ent", "<e2>", ",", "indicative", "of", "latent", "MMP", "activation", ",", "were", "increased", "in", "more", "aggressive", "sublines", "."], "h": {"id": "C1417205", "name": "C1417205#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1568288", "name": "C1568288#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "C1419394#ent", "<e1>", "for", "the", "differences", "between", "the", "final", "and", "ascending", "C0030196#ent", "<e2>", "EEG", "power", "were", "not", "significant", ",", "except", "for", "the", "theta", "band", "."], "h": {"id": "C1419394", "name": "C1419394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [13, 14]}}
{"token": ["Second", ",", "C3714973#ent", "<e1>", "to", "promote", "the", "subsequent", "association", "of", "C0209328#ent", "<e2>", "which", "is", "involved", "in", "clathrin-mediated", "endocytic", "processing", "with", "the", "complex", "."], "h": {"id": "C3714973", "name": "C3714973#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0209328", "name": "C0209328#ent", "pos": [10, 11]}}
{"token": ["Subsequent", "immunohistochemical", "analysis", "that", "most", "of", "these", "neurons", "contained", "immunoreactivity", "to", "calcitonin", "gene-related", "peptide", "C1367551#ent", "<e1>", ")", ",", "suggesting", "that", "they", "belong", "to", "the", "C0242893#ent", "<e2>", "of", "the", "scattered", "type", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [24, 25]}}
{"token": ["We", "sought", "to", "examine", "the", "effect", "of", "the", "angiotensin-converting-enzyme", "(ACE)", "inhibitor", "C0136123#ent", "<e1>", "on", "physical", "function", "elderly", "people", "functional", "impairment", "had", "C0018802#ent", "<e2>", "left", "ventricular", "systolic", "dysfunction"], "h": {"id": "C0136123", "name": "C0136123#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["The", "PEP-CHF", "study", "suggests", "that", "C0136123#ent", "<e1>", "improves", "symptoms", "and", "functional", "capacity", "and", "may", "reduce", "C0018802#ent", "<e2>", "hospitalisations", "in", "patients", "with", "diastolic", "heart", "failure"], "h": {"id": "C0136123", "name": "C0136123#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["In", "this", "review", "firstly", "we", "discuss", "the", "relationship", "between", "C3150902#ent", "<e1>", "consumption", "and", "C0024138#ent", "<e2>", "."], "h": {"id": "C3150902", "name": "C3150902#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [13, 14]}}
{"token": ["Each", "neuronal", "population", "mRNA", "for", "several", "types", "of", "C1413403#ent", "<e1>", "including", "alpha6", "and", "C1420841#ent", "<e2>", "."], "h": {"id": "C1413403", "name": "C1413403#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420841", "name": "C1420841#ent", "pos": [13, 14]}}
{"token": ["The", "diagnosis", "should", "be", "sought", "even", "in", "the", "absence", "of", "C3665358#ent", "<e1>", "and", "sellar", "abnormality", "particularly", "when", "thelarche", "and", "C0342541#ent", "<e2>", "have", "occurred", "."], "h": {"id": "C3665358", "name": "C3665358#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0342541", "name": "C0342541#ent", "pos": [19, 20]}}
{"token": ["The", "distribution", "of", "carbohydrates", "among", "C0030956#ent", "<e1>", "of", "basement-membrane-like", "material", "on", "sodium", "dodecyl", "sulphate/polyacrylamide-gel", "electrophoresis", "investigated", "after", "labelling", "with", "C0024742#ent", "<e2>", ",", "[3H]fucose", ",", "[3H]galactose", "and", "[3H]glucosamine", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024742", "name": "C0024742#ent", "pos": [19, 20]}}
{"token": ["Inheritance", "of", "the", "TPMT*2", ",", "TPMT*3A", "and", "C1336663#ent", "<e1>", "mutant", "alleles", "is", "associated", "with", "deficiency", "of", "C1336737#ent", "<e2>", "TPMT", ")", "activity", "in", "humans", "."], "h": {"id": "C1336663", "name": "C1336663#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1336737", "name": "C1336737#ent", "pos": [16, 17]}}
{"token": ["This", "study", "investigated", "the", "mechanism", "of", "C0028928#ent", "<e1>", "OA", ")", "on", "gap", "junctions", "identified", "the", "C0033634#ent", "<e2>", "PKC", ")", "isoforms", "involved", "in", "OA-mediated", "gap", "junction", "disassembly", "in", "cardiomyocytes", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [15, 16]}}
{"token": ["Anaphylactoid", "shock", "disseminated", "intravascular", "coagulation", "and", "C0035078#ent", "<e1>", "dialysis", "occurred", "in", "a", "patient", "receiving", "C0149477#ent", "<e2>", "toothache", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0149477", "name": "C0149477#ent", "pos": [14, 15]}}
{"token": ["The", "differences", "in", "C2985148#ent", "<e1>", "phenotypes", "may", "be", "suggested", "to", "be", "due", "to", "C2917660#ent", "<e2>", "substitutions", "of", "the", "C2985148#ent", "<e1>", "molecule", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2985148", "name": "C2985148#ent", "pos": [3, 4]}}
{"token": ["Simultaneously", ",", "there", "was", "marked", "improvement", "in", "Parkinsonian", "C1457887#ent", "<e1>", "almost", "complete", "resolution", "of", "the", "C0040822#ent", "<e2>", ",", "start", "hesitation", "and", "freezing", "of", "gait", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040822", "name": "C0040822#ent", "pos": [15, 16]}}
{"token": ["Scabies", "(", "C0024709#ent", "<e1>", ")", "is", "a", "C0037274#ent", "<e2>", "men", "and", "animals", "caused", "by", "microscopical", "acarids", "."], "h": {"id": "C0024709", "name": "C0024709#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}}
{"token": ["The", "patient", "also", "suffered", "from", "C0242343#ent", "<e1>", "with", "hyperprolactinemia", "and", "C0687720#ent", "<e2>", "by", "lymphocytic", "hypophysitis"], "h": {"id": "C0242343", "name": "C0242343#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0687720", "name": "C0687720#ent", "pos": [10, 11]}}
{"token": ["The", "diagnostic", "challenge", "hypothalamic-pituitary", "LCH", "emphasized", "in", "cases", "revealed", "as", "supra-sellar", "tumors", "with", "C0242343#ent", "<e1>", "or", "as", "isolated", "C0687720#ent", "<e2>"], "h": {"id": "C0242343", "name": "C0242343#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0687720", "name": "C0687720#ent", "pos": [18, 19]}}
{"token": ["The", "youngest", "child", "was", "a", "20-day-old", "neonate", "(", "age", "range", "20", "days-12", "C1710700#ent", "<e1>", ")", "with", "a", "peak", "of", "C0026946#ent", "<e2>", "in", "patients", "between", "4", "and", "6", "years", "of", "age", "."], "h": {"id": "C1710700", "name": "C1710700#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [19, 20]}}
{"token": ["A", "case", "of", "C0263409#ent", "<e1>", "the", "forehead", "(", "C0392441#ent", "<e2>", "is", "described", "."], "h": {"id": "C0263409", "name": "C0263409#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0392441", "name": "C0392441#ent", "pos": [8, 9]}}
{"token": ["Extrapolating", "these", "results", "across", "the", "health", "economy", "an", "estimate", "has", "been", "made", "of", "a", "potential", "pound153.7", "million", "per", "year", "saving", "on", "C0023223#ent", "<e1>", "to", "the", "C0796085#ent", "<e2>", "."], "h": {"id": "C0023223", "name": "C0023223#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0796085", "name": "C0796085#ent", "pos": [25, 26]}}
{"token": ["Site-directed", "mutagenesis", "confirms", "the", "importance", "of", "this", "loop", "to", "C1947941#ent", "<e1>", "trafficking", "and", "suggests", "that", "a", "protein", "motif", "signal", "for", "C0108471#ent", "<e2>", "early", "in", "eukaryotic", "cell", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [20, 21]}}
{"token": ["Treatment", "of", "seminalplasmin", "with", "the", "above", "C1947941#ent", "<e1>", "as", "well", "as", "with", "amino", "peptidase", "M", "C0108471#ent", "<e2>", "eliminated", "biological", "activity"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [15, 16]}}
{"token": ["The", "agonist-induced", "tyrosine", "phosphorylation", "C1449330#ent", "<e1>", "was", "blocked", "by", "inhibitors", "of", "Src", "family", "kinases", "and", "C1449330#ent", "<e1>", "was", "coprecipitated", "with", "C1442788#ent", "<e1>", "(", "but", "not", "Src", ")", "in", "an", "agonist-dependent", "manner", "."], "h": {"id": "C1449330", "name": "C1449330#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [20, 21]}}
{"token": ["To", "assess", "the", "utility", "of", "C1412374#ent", "<e1>", "AMACR", ")", ",", "also", "known", "as", "C1172764#ent", "<e2>", ",", "immunohistochemistry", "in", "the", "detection", "of", "postradiation", "prostatic", "adenocarcinoma", "surgical", "specimens"], "h": {"id": "C1412374", "name": "C1412374#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1172764", "name": "C1172764#ent", "pos": [13, 14]}}
{"token": ["To", "assess", "the", "utility", "of", "alpha-methylacyl-coenzyme", "A", "racemase", "C1412374#ent", "<e1>", ")", ",", "also", "known", "as", "C1172764#ent", "<e2>", ",", "immunohistochemistry", "in", "the", "detection", "of", "postradiation", "prostatic", "adenocarcinoma", "surgical", "specimens"], "h": {"id": "C1412374", "name": "C1412374#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1172764", "name": "C1172764#ent", "pos": [15, 16]}}
{"token": ["Cytochrome", "P-450-dependent", "monooxygenation", "CCNU", "gave", "only", "alicyclic", "hydroxylation", "products", ",", "but", "monooxygenation", "of", "C0036637#ent", "<e1>", "gave", "alicyclic", "hydroxylation", "products", ",", "an", "C0038302#ent", "<e2>", "product", "on", "the", "2-chloroethyl", "moiety", ",", "and", "a", "trans-4-hydroxymethyl", "product", "."], "h": {"id": "C0036637", "name": "C0036637#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038302", "name": "C0038302#ent", "pos": [21, 22]}}
{"token": ["Inhibition", "of", "phospholipase", "A2", "C0012050#ent", "<e1>", "and", "Ca2", "+", "activated", "proteases", "by", "antipain", "and", "C0064858#ent", "<e2>", "also", "reduced", "t-BHP", "induced", "swelling", "."], "h": {"id": "C0012050", "name": "C0012050#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0064858", "name": "C0064858#ent", "pos": [14, 15]}}
{"token": ["Placental", "sulfatase", "deficiency", "PSD", ")", "is", "a", "rare", "disorder", "with", "low", "C2936882#ent", "<e1>", "production", "due", "to", "placental", "C0162429#ent", "<e2>"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [17, 18]}}
{"token": ["The", "success", "of", "recent", "launches", "of", "protein", "kinase", "inhibitors", "Gleevec", ",", "C0935989#ent", "<e1>", ",", "Sutent", ",", "Iressa", ",", "C1677799#ent", "<e2>", ",", "Sprycel", ")", "gave", "another", "push", "to", "this", "field", "."], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1677799", "name": "C1677799#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "C0007262#ent", "<e1>", ",", "an", "inhibitor", "of", "protein", "kinase", "C", "inhibited", "epidermal", "C1704862#ent", "<e2>", "induction", "and", "the", "increased", "level", "of", "C1704862#ent", "<e2>", "mRNA", "by", "TPA", "."], "h": {"id": "C0007262", "name": "C0007262#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704862", "name": "C1704862#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "the", "obese", "gene", "C2986870#ent", "<e1>", ")", "or", "in", "the", "C0079429#ent", "<e2>", "encoding", "the", "OB", "receptor(OB-R", ")", "result", "in", "obesity", ",", "infertility", "and", "diabetes", "in", "a", "variety", "of", "mouse", "phenotypes", "."], "h": {"id": "C2986870", "name": "C2986870#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["Obese", "(", "C2986870#ent", "<e1>", ")", "is", "a", "recently", "identified", "C0079429#ent", "<e2>", "involved", "in", "the", "regulation", "of", "energy", "balance", "the", "mouse", "."], "h": {"id": "C2986870", "name": "C2986870#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["The", "Reduction", "of", "Endpoints", "in", "C3273872#ent", "<e1>", "with", "the", "C0521942#ent", "<e2>", "RENAAL", ")", "study", "has", "previously", "shown", "losartan", "to", "confer", "significant", "benefits", "to", "patients", "with", "type", "2", "diabetes", "nephropathy", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0521942", "name": "C0521942#ent", "pos": [9, 10]}}
{"token": ["Both", "the", "Irbesartan", "Diabetic", "Nephropathy", "Trial", "IDNT", ")", "and", "the", "Reduction", "in", "Endpoints", "in", "C3273872#ent", "<e1>", "with", "the", "C0521942#ent", "<e2>", "RENAAL", ")", "study", "were", "large", ",", "randomized", ",", "prospective", "studies", "type", "2", "diabetic", "patients", "with", "proteinuria", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0521942", "name": "C0521942#ent", "pos": [18, 19]}}
{"token": ["However", ",", "capsule", ",", "C0669516#ent", "<e1>", "phospholipase", ",", "and", "C0041945#ent", "<e2>", "were", "unaffected", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041945", "name": "C0041945#ent", "pos": [9, 10]}}
{"token": ["We", "identified", "the", "Ral", "guanine", "nucleotide", "exchange", "factor-like", "factor", "C0035344#ent", "<e1>", ")", "in", "a", "yeast", "two-hybrid", "screen", "human", "heart", "cDNA", "library", "using", "C0525678#ent", "<e2>", "as", "bait", ",", "suggesting", "that", "Ras", "signaling", "the", "heart", "may", "involve", "C0035344#ent", "<e1>", "."], "h": {"id": "C0035344", "name": "C0035344#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [22, 23]}}
{"token": ["These", "binding", "characteristics", "indicate", "that", "C0035344#ent", "<e1>", "is", "a", "putative", "effector", "for", "C0525678#ent", "<e2>", "and", "Rap", "1A"], "h": {"id": "C0035344", "name": "C0035344#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [12, 13]}}
{"token": ["C0700636#ent", "<e1>", "FNH", ")", "can", "imitate", "liver", "cirrhosis", "steatohepatitis", ",", "C0008311#ent", "<e2>", "or", "chronic", "hepatitis", "if", "biopsy", "material", "does", "not", "include", "normal", "perilesional", "liver", "tissue", "."], "h": {"id": "C0700636", "name": "C0700636#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [10, 11]}}
{"token": ["Avian", "pneumovirus", "APV", ")", "is", "the", "cause", "of", "a", "C0035242#ent", "<e1>", "turkeys", "characterized", "by", "coughing", ",", "ocular", "and", "C1260880#ent", "<e2>", "and", "swelling", "of", "the", "infraorbital", "sinuses"], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [18, 19]}}
{"token": ["Pharmacological", "differences", "between", "the", "commonly", "available", "C0360055#ent", "<e1>", "dolasetron", ",", "granisetron", ",", "ondansetron", ",", "tropisetron", "and", "C0220578#ent", "<e2>", ")", ",", "namely", "receptor", "sensitivity", "duration", "of", "action", "metabolism", "and", "tolerability", "profile"], "h": {"id": "C0360055", "name": "C0360055#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0220578", "name": "C0220578#ent", "pos": [16, 17]}}
{"token": ["Four", "of", "the", "C0360055#ent", "<e1>", "dolasetron", ",", "ondansetron", ",", "C0220578#ent", "<e2>", ",", "and", "tropisetron", ")", "are", "metabolized", "in", "various", "degrees", "via", "CYP2D6", ",", "an", "isoform", "subject", "to", "marked", "genetic", "polymorphism"], "h": {"id": "C0360055", "name": "C0360055#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0220578", "name": "C0220578#ent", "pos": [9, 10]}}
{"token": ["C4084905#ent", "<e1>", ",", "acting", "through", "a", "distinct", "C1439290#ent", "<e2>", "induced", "DNA", "synthesis", "serum-starved", "cultured", "mesangial", "cells"], "h": {"id": "C4084905", "name": "C4084905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1439290", "name": "C1439290#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "suggested", "that", "the", "patient's", "C0002878#ent", "<e1>", "red", "cell", "deformities", "due", "to", "abnormal", "copper", "metabolism", "associated", "with", "C0019202#ent", "<e2>"], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "27-year-old", "woman", "who", "developed", "Coombs'", "negative", "C0002878#ent", "<e1>", "fulminant", "hepatic", "failure", "the", "initial", "manifestation", "of", "C0019202#ent", "<e2>"], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "patient", "who", "developed", "C0002878#ent", "<e1>", "fulminant", "hepatic", "failure", "the", "initial", "manifestations", "of", "C0019202#ent", "<e2>"], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [15, 16]}}
{"token": ["Low", "cardiac", "output", "C1416807#ent", "<e1>", ")", "was", "observed", "in", "all", "patients", "who", "developed", "C1705280#ent", "<e2>", "and", "in", "72/255", "without", "C1705280#ent", "<e2>", "(", "p", "<", "0.0005", ")", "."], "h": {"id": "C1416807", "name": "C1416807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [13, 14]}}
{"token": ["This", "study", "identified", "C1416807#ent", "<e1>", "associated", "to", "prolonged", "perfusion", "time", "and", "sepsis", "as", "risk", "factors", "C1705280#ent", "<e2>", "."], "h": {"id": "C1416807", "name": "C1416807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [15, 16]}}
{"token": ["A", "60-year-old", "woman", "without", "any", "risk", "factors", "C0010054#ent", "<e1>", "with", "symptomatic", ",", "recurrent", ",", "C0750197#ent", "<e2>"], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0750197", "name": "C0750197#ent", "pos": [14, 15]}}
{"token": ["The", "establishment", "and", "maintenance", "of", "C0004623#ent", "<e1>", "a", "pre-requisite", "for", "all", "the", "pathological", "sequelae", "of", "C0025303#ent", "<e2>"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0025303", "name": "C0025303#ent", "pos": [15, 16]}}
{"token": ["Despite", "rapid", "advances", "in", "the", "diagnosis", "of", "C0004623#ent", "<e1>", "the", "availability", "of", "effective", "antibiotics", ",", "C0025303#ent", "<e2>", "to", "represent", "a", "substantial", "public", "health", "for", "most", "countries", "(", "1", "-", "4", ")", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0025303", "name": "C0025303#ent", "pos": [15, 16]}}
{"token": ["Insulin", "resistance", "frequently", "observed", "in", "patients", "with", "essential", "hypertension", "C3540573#ent", "<e1>", ")", ",", "and", "the", "renin-angiotensin", "system", "C0034678#ent", "<e2>", ")", "has", "been", "demonstrated", "to", "modulate", "the", "status", "of", "insulin", "resistance"], "h": {"id": "C3540573", "name": "C3540573#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [17, 18]}}
{"token": ["Factor", "IX", "C0015518#ent", "<e1>", "sialic", "acid", "O-linked", "and", "N-linked", "oligosaccharides", "their", "C0030956#ent", "<e2>", "and", "a", "terminal", "sialic", "acid", "found", "on", "a", "recently", "described", "O-linked", "tetrasaccharide", "at", "Ser-61", "in", "the", "light", "chain", "human", "factor", "IXa"], "h": {"id": "C0015518", "name": "C0015518#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}}
{"token": ["Seventy-one", "(", "73.96", "per", "cent", ")", "present", "clinical", "manifestation", "C0030193#ent", "<e1>", "ulcerations", ",", "and", "only", "25", "cases", "(", "26.4", "per", "C0021775#ent", "<e2>", "to", "R.", "Fontain", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021775", "name": "C0021775#ent", "pos": [20, 21]}}
{"token": ["Permanent", "consequences", "of", "transient", "C1739148#ent", "<e1>", "of", "the", "C3538851#ent", "<e2>", "as", "elongation", "of", "the", "extremity", "and", "coxa", "magna", "X-ray", "pictures", "are", "rarely", "observed", "."], "h": {"id": "C1739148", "name": "C1739148#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538851", "name": "C3538851#ent", "pos": [8, 9]}}
{"token": ["These", "results", "demonstrate", "that", "hypermetabolism", "does", "not", "invariably", "result", "in", "loss", "of", "lean", "body", "mass", "suggest", "that", "C0008932#ent", "<e1>", "may", "be", "useful", "in", "preserving", "muscle", "mass", "protein", "in", "C0025517#ent", "<e2>"], "h": {"id": "C0008932", "name": "C0008932#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [28, 29]}}
{"token": ["The", "C0003195#ent", "<e1>", "efficacy", "of", "C0543459#ent", "<e2>", "Mexitil", ")", "was", "evaluated", "in", "100", "patients", "with", "potentially", "lethal", "and", "drug-resistant", "ventricular", "arrhythmia"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [5, 6]}}
{"token": ["The", "C0003195#ent", "<e1>", "efficacy", "of", "C0543459#ent", "<e2>", "studied", "in", "ten", "selected", "patients", "with", "stable", "resistant", "ventricular", "ectopic", "activity", "in", "whom", "lidocaine", ",", "procainamide", ",", "and", "other", "antiarrhythmic", "agents", "of", "no", "avail", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [5, 6]}}
{"token": ["Enhancement", "of", "aqueous", "solubility", ",", "dissolution", "rate", ",", "and", "bioavailability", "of", "C1254351#ent", "<e1>", "is", "a", "very", "challenging", "C0310298#ent", "<e2>", "in", "drug", "development"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [17, 18]}}
{"token": ["Gastrointestinal", "dysfunction", "C0235394#ent", "<e1>", "are", "frequent", "complications", "of", "C3854222#ent", "<e2>", "HIV", ")", "infection", "."], "h": {"id": "C0235394", "name": "C0235394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [8, 9]}}
{"token": ["We", "report", "on", "a", "15-month-old", "boy", "with", "C0221333#ent", "<e1>", "presented", "with", "acute", "renal", "failure", "anuria", "and", "C0036690#ent", "<e2>", "due", "to", "bilateral", "obstructing", "ureteral", "uric", "acid", "stones"], "h": {"id": "C0221333", "name": "C0221333#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "different", "lactones", "on", "the", "barley", "preparation", "suggest", "that", "alpha-l-arabinosidase", "activity", "associated", "with", "C0005220#ent", "<e1>", "rather", "than", "with", "the", "enzyme", "that", "hydrolyses", "C0005223#ent", "<e2>", "and", "beta-d-fucosides", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [24, 25]}}
{"token": ["Though", "C0563238#ent", "<e1>", ",", "and", "especially", "C0085695#ent", "<e2>", "is", "observed", "at", "least", "histologically", "in", "all", "persons", "with", "H.", "pylori", "peptic", "ulcers", "in", "only", "some", "infected", "persons", "."], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085695", "name": "C0085695#ent", "pos": [6, 7]}}
{"token": ["SU5416", "(", "Z-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone", ";", "C1135174#ent", "<e1>", ")", "is", "a", "small", "molecule", "inhibitor", "of", "the", "vascular", "endothelial", "growth", "factor", "receptor", "C1334306#ent", "<e2>", ")", "."], "h": {"id": "C1135174", "name": "C1135174#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334306", "name": "C1334306#ent", "pos": [19, 20]}}
{"token": ["C0031069#ent", "<e1>", "FMF", ")", "is", "a", "C0019247#ent", "<e2>", "episodic", "fever", "in", "combination", "with", "severe", "abdominal", "pain", "pleurisy", ",", "arthritis", "or", "erysipelas-like", "skin", "rashes", "."], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [6, 7]}}
{"token": ["Efficient", "refolding", "of", "C1334435#ent", "<e1>", "by", "Ssa1p", "and", "C1428391#ent", "<e2>", ",", "but", "not", "by", "DnaK", "and", "Ydj1p", ",", "suggests", "that", "a", "compatible", "Hsp70/DnaJ", "homolog", "pair", "can", "act", "as", "a", "protein", "folding", "machinery"], "h": {"id": "C1334435", "name": "C1334435#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428391", "name": "C1428391#ent", "pos": [8, 9]}}
{"token": ["Ultrasound", "was", "used", "to", "increase", "the", "extraction", "efficiency", "of", "C0074007#ent", "<e1>", "the", "herb", "Rosmarinus", "officinalis", "using", "butanone", ",", "C0059747#ent", "<e2>", "ethanol", "as", "solvents", "."], "h": {"id": "C0074007", "name": "C0074007#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0059747", "name": "C0059747#ent", "pos": [18, 19]}}
{"token": ["Recently", "the", "C0017337#ent", "<e1>", "for", "HH", "(", "C1384665#ent", "<e2>", "has", "been", "located", "on", "chromosome", "6"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1384665", "name": "C1384665#ent", "pos": [7, 8]}}
{"token": ["There", "was", "no", "relationship", "between", "hepcidin", "mRNA", "levels", "and", "those", "of", "C0017337#ent", "<e1>", "controlling", "iron", "metabolism", "including", "C1384665#ent", "<e2>", ",", "hemojuvelin", ",", "transferrin", "receptor-2", "ferroportin", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1384665", "name": "C1384665#ent", "pos": [17, 18]}}
{"token": ["These", "results", "demonstrate", "a", "role", "for", "both", "C1413694#ent", "<e1>", "and", "CR3", "in", "the", "opsonophagocytosis", "of", "C2020625#ent", "<e2>", "."], "h": {"id": "C1413694", "name": "C1413694#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2020625", "name": "C2020625#ent", "pos": [15, 16]}}
{"token": ["The", "activation", "of", "LYN-associated", "PI3-kinase", "unrelated", "to", "changes", "in", "the", "amount", "of", "PI3-kinase", "physically", "associated", "with", "C1442804#ent", "<e1>", "signaling", "complexes", "but", "did", "require", "the", "activation", "of", "C1442804#ent", "<e1>", "and", "other", "C0033681#ent", "<e1>"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [16, 17]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [30, 31]}}
{"token": ["This", "cDNA", "clone", "partially", "sequenced", "and", "proved", "to", "be", "identical", "to", "part", "of", "C1442804#ent", "<e1>", ",", "a", "recently", "reported", "putative", "C0033681#ent", "<e2>"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [20, 21]}}
{"token": ["A", "phase", "I/II", "clinical", "trial", "demonstrated", "the", "efficacy", "of", "TTM", "in", "patients", "with", "C0085786#ent", "<e1>", "and", "led", "the", "FDA", "to", "grant", "TTM", "C0013232#ent", "<e2>", "this", "disease", "."], "h": {"id": "C0085786", "name": "C0085786#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013232", "name": "C0013232#ent", "pos": [22, 23]}}
{"token": ["We", "previously", "described", "the", "deficiency", "of", "C4084892#ent", "<e1>", "CFHR1", "and", "CFHR3", "as", "predisposing", "factor", "C4283801#ent", "<e2>", "."], "h": {"id": "C4084892", "name": "C4084892#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [14, 15]}}
{"token": ["These", "newer", "oral", "antifungal", "agents", "been", "proven", "effective", "against", "C0040250#ent", "<e1>", "effective", "regimens", "are", "shorter", "than", "those", "for", "C0018242#ent", "<e2>", "."], "h": {"id": "C0040250", "name": "C0040250#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0018242", "name": "C0018242#ent", "pos": [18, 19]}}
{"token": ["Itraconazole", "and", "terbinafine", "seem", "to", "be", "equally", "or", "more", "effective", "in", "treatment", "of", "C0040250#ent", "<e1>", "a", "shorter", "period", "of", "time", "than", "C0018242#ent", "<e2>", "."], "h": {"id": "C0040250", "name": "C0040250#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0018242", "name": "C0018242#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "C0003277#ent", "<e1>", "to", "SREBP", "maturation", ",", "increased", "C1412089#ent", "<e2>", "expression", "and", "reduced", "VLCFA", "accumulation", "."], "h": {"id": "C0003277", "name": "C0003277#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412089", "name": "C1412089#ent", "pos": [9, 10]}}
{"token": ["Carnitine", "palmitoyltransferase", "II", "C0524513#ent", "<e1>", "deficiency", "is", "the", "most", "common", "C0026848#ent", "<e2>", "adults", "and", "is", "characterized", "by", "exercise-induced", "pain", "stiffness", ",", "and", "myoglobinuria", "."], "h": {"id": "C0524513", "name": "C0524513#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [10, 11]}}
{"token": ["C0524513#ent", "<e1>", "CPT", "II", "deficiency", "is", "the", "most", "common", "C0026848#ent", "<e2>", "adults", "and", "is", "characterized", "by", "exercise-induced", "pain", "stiffness", ",", "and", "myoglobinuria", "."], "h": {"id": "C0524513", "name": "C0524513#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [9, 10]}}
{"token": ["The", "activity", "of", "C1826418#ent", "<e1>", "more", "than", "did", "the", "activities", "of", "C0038615#ent", "<e2>", "lipoamide", "dehydrogenase", "or", "cytochrome-c", "oxidase", "both", "homogenates", "and", "in", "mitochondrial", "fractions"], "h": {"id": "C1826418", "name": "C1826418#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038615", "name": "C0038615#ent", "pos": [11, 12]}}
{"token": ["To", "elucidate", "the", "mechanism", "of", "gastric", "hypersecretion", "induced", "by", "cysteamine", ",", "the", "effects", "of", "C1161352#ent", "<e1>", ",", "cimetidine", ",", "proglumide", ",", "C0086073#ent", "<e2>", "tranilast", "on", "the", "cysteamine", "response", "were", "studied", "in", "rats", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0086073", "name": "C0086073#ent", "pos": [21, 22]}}
{"token": ["The", "C0525036#ent", "<e1>", "detected", "by", "fluorescence", "in", "situ", "hybridisation", "FISH", ")", ",", "whereas", "C0086661#ent", "<e2>", "and", "Bcl2", "genes", "translocation", "were", "absent", "."], "h": {"id": "C0525036", "name": "C0525036#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [13, 14]}}
{"token": ["Taken", "together", ",", "our", "data", "define", "a", "new", "pathway", "for", "gene", "regulation", "C0086661#ent", "<e1>", "and", "show", "that", "the", "C0525036#ent", "<e2>", "a", "target", "gene", "for", "repression", "by", "C0086661#ent", "<e1>", "."], "h": {"id": "C0525036", "name": "C0525036#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "electrophoretic", "mobility", "shift", "assay", "that", "C0001486#ent", "<e1>", "JNK", "increases", "the", "activator", "protein", "activity", "of", "the", "C1704939#ent", "<e2>", "the", "MDR", "cells"], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [18, 19]}}
{"token": ["TRPC3", ",", "but", "not", "C1421173#ent", "<e1>", ",", "coimmunoprecipitated", "with", "C1412492#ent", "<e2>", "from", "both", "medulla", "and", "M1", "and", "IMCD-3", "cell", "lysates", "."], "h": {"id": "C1421173", "name": "C1421173#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412492", "name": "C1412492#ent", "pos": [9, 10]}}
{"token": ["93", "patients", "with", "C0038013#ent", "<e1>", "RA", ")", "were", "given", "diet", "therapy", "unloading", "diets", "(", "C4283796#ent", "<e2>", ")", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [14, 15]}}
{"token": ["C0038644#ent", "<e1>", "of", "multiply", "C0030956#ent", "<e2>", "illustrated", "for", "peptides", "with", "molecular", "mass", "up", "to", "approximately", "5000", "u."], "h": {"id": "C0038644", "name": "C0038644#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}}
{"token": ["Symptoms", "and", "signs", "of", "extrapyramidal", "system", "C1822796#ent", "<e1>", "greater", "than", "C0037506#ent", "<e2>", "greater", "than", "OPCA", ",", "autonomic", "dysfunction", "C0037506#ent", "<e2>", "greater", "than", "OPCA", "greater", "than", "C1822796#ent", "<e1>", "."], "h": {"id": "C1822796", "name": "C1822796#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [10, 11]}}
{"token": ["Nicorandil", ",", "an", "C1422492#ent", "<e1>", "of", "ATP-sensitive", "potassium", "channels", "a", "nitrate-like", "action", ",", "is", "a", "potent", "C0042402#ent", "<e2>", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [16, 17]}}
{"token": ["This", "macromolecular", "assemblage", "the", "bifunctional", "glutamyl-prolyl-tRNA", "synthetase", "the", "seven", "monospecific", "isoleucyl", ",", "leucyl", ",", "methionyl", ",", "glutaminyl", ",", "lysyl", ",", "arginyl", "and", "C1413909#ent", "<e1>", "and", "the", "three", "auxiliary", "p43", ",", "p38", "and", "C1416968#ent", "<e2>"], "h": {"id": "C1413909", "name": "C1413909#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1416968", "name": "C1416968#ent", "pos": [32, 33]}}
{"token": ["Joubert", "syndrome", "an", "C3899988#ent", "<e1>", "by", "hypotonia", ",", "C0004134#ent", "<e2>", ",", "developmental", "delay", "and", "a", "distinctive", "hindbrain", "malformation", "the", "cerebellum", "and", "brain", "stem", "visualized", "radiographically", "on", "magnetic", "resonance", "imaging", "MRI", ")", "as", "the", "\"", "molar", "tooth", "sign"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [8, 9]}}
{"token": ["These", "changes", "also", "occurred", "in", "the", "presence", "of", "C0013973#ent", "<e1>", "(", "an", "inhibitor", "of", "protein", "synthesis", "and", "C1516035#ent", "<e2>", "(", "an", "inhibitor", "of", "DNA", "synthesis", "."], "h": {"id": "C0013973", "name": "C0013973#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1516035", "name": "C1516035#ent", "pos": [17, 18]}}
{"token": ["An", "outbreak", "of", "C0014347#ent", "<e1>", "variable", "susceptibility", "to", "C3540047#ent", "<e2>", "occurred", "in", "the", "University", "Medical", "Center", "Utrecht", "the", "Netherlands", "in", "2002", "."], "h": {"id": "C0014347", "name": "C0014347#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540047", "name": "C3540047#ent", "pos": [8, 9]}}
{"token": ["The", "carbapenems", ",", "especially", "meropenem", ",", "consistently", "demonstrated", "the", "lowest", "resistance", "rates", "against", "C0014347#ent", "<e1>", "and", "the", "C3540047#ent", "<e2>", "had", "the", "highest", "and", "increasing", "resistance", "rates", "."], "h": {"id": "C0014347", "name": "C0014347#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540047", "name": "C3540047#ent", "pos": [17, 18]}}
{"token": ["The", "resulting", "impairment", "of", "MSA", "information", "has", "been", "suggested", "to", "be", "involved", "in", "the", "C1414672#ent", "<e1>", "and", "spread", "of", "C0746668#ent", "<e2>"], "h": {"id": "C1414672", "name": "C1414672#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0746668", "name": "C0746668#ent", "pos": [19, 20]}}
{"token": ["C3813553#ent", "<e1>", "is", "an", "C1834674#ent", "<e2>", "characterized", "by", "multiple", "brain", "infarcts", ",", "cognitive", "decline", "and", "finally", "dementia", ",", "which", "is", "caused", "by", "mutations", "in", "Notch3", "gene", "encoding", "a", "Notch3", "receptor", "protein"], "h": {"id": "C3813553", "name": "C3813553#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1834674", "name": "C1834674#ent", "pos": [4, 5]}}
{"token": ["Age", ",", "gender", ",", "tobacco", "smoking", "the", "presence", "of", "C0037090#ent", "<e1>", "increased", "serum", "levels", "of", "ALT", "and", "C3812647#ent", "<e2>", ",", "and", "the", "town", "of", "residence", "were", "powerful", "predictors", "."], "h": {"id": "C0037090", "name": "C0037090#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3812647", "name": "C3812647#ent", "pos": [17, 18]}}
{"token": ["C0006376#ent", "<e1>", ",", "at", "doses", "that", "selectively", "block", "the", "C1420095#ent", "<e2>", "NKCC1", ",", "produced", "a", "hyperpolarizing", "shift", "in", "GABA(A", ")", "reversal", "potentials", "and", "suppressed", "interictal", "activity", "."], "h": {"id": "C0006376", "name": "C0006376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420095", "name": "C1420095#ent", "pos": [9, 10]}}
{"token": ["Therapy", "with", "C3541971#ent", "<e1>", ",", "vitamin", "D", "androgens", "and", "C0012544#ent", "<e2>", "have", "been", "studied", "and", "their", "results", "and", "side", "effects", "reviewed", "."], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [9, 10]}}
{"token": ["C3541971#ent", "<e1>", "stimulates", "trabecular", "bone", "formation", ",", "whereas", "C0012544#ent", "<e2>", "reduce", "bone", "resorption", "turnover", "."], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [8, 9]}}
{"token": ["Drugs", "act", "by", "stimulation", "of", "bone", "formation", "C3541971#ent", "<e1>", ")", "or", "inhibition", "of", "bone", "resorption", "calcium", ",", "vitamin", "D", "compounds", "C0012544#ent", "<e2>", ",", "hormone", "replacement", "therapy", "calcitonin", ")", "."], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [20, 21]}}
{"token": ["C1415900#ent", "<e1>", "enhancement", "of", "TNF-induced", "expression", "is", "also", "seen", "using", "C1366498#ent", "<e2>", "to", "the", "minimal", "cytokine", "inducible", "VCAM-1", "promoter", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366498", "name": "C1366498#ent", "pos": [10, 11]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "compare", "the", "analgesic", "efficacy", "C1169987#ent", "<e1>", "(", "APAP", ")", "(", "total", "dose", "mg/650", "mg", ")", "and", "C0040610#ent", "<e2>", "(", "total", "dose", "mg", ")", "for", "the", "control", "of", "after", "oral", "surgery"], "h": {"id": "C1169987", "name": "C1169987#ent", "pos": [11, 12]}, "relation": "has_constitutional_part", "t": {"id": "C0040610", "name": "C0040610#ent", "pos": [23, 24]}}
{"token": ["Furthermore", ",", "this", "is", "the", "first", "demonstration", "of", "significant", "elevation", "of", "plasma", "C1332801#ent", "<e1>", "in", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C1332801", "name": "C1332801#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["Variety", "of", "genetic", "forms", "C3273279#ent", "<e1>", "due", "to", "C0268487#ent", "<e2>", "of", "factor", "H", "membrane", "cofactor", "protein", "Von", "Willebrand", "factor-cleaving", "protease", "ADAMTS", "13", "and", "intracellular", "defect", "vitamin", "B12", "metabolism", "."], "h": {"id": "C3273279", "name": "C3273279#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [8, 9]}}
{"token": ["C0017160#ent", "<e1>", "caused", "by", "C3534585#ent", "<e2>", "been", "described", "as", "a", "highly", "seasonal", "syndrome", "often", "referred", "to", "as", "\"", "winter", "vomiting", "disease", "."], "h": {"id": "C0017160", "name": "C0017160#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C3534585", "name": "C3534585#ent", "pos": [4, 5]}}
{"token": ["The", "acetylcholine", "receptor", "been", "considered", "the", "primary", "site", "antibody", "binding", "however", ",", "other", "C1136365#ent", "<e1>", "be", "involved", "in", "the", "pathogenesis", "of", "C0026896#ent", "<e2>"], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [21, 22]}}
{"token": ["A", "60-year-old", "man", "developed", "disorientation", ",", "euphoria", ",", "hyperactive", "behavior", "mental", "confusion", "and", "a", "moderate", "decrease", "of", "cognition", "during", "the", "course", "of", "relapsing", "polychondritis", "bilateral", "auricular", "chondritis", ",", "C4021534#ent", "<e1>", "episcleritis", "and", "C0151219#ent", "<e2>"], "h": {"id": "C4021534", "name": "C4021534#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0151219", "name": "C0151219#ent", "pos": [32, 33]}}
{"token": ["An", "additional", "construct", "resulting", "in", "a", "full-length", "C0021965#ent", "<e1>", "peptide", "with", "an", "internal", "deletion", "of", "C0815040#ent", "<e2>", "455", "was", "also", "made", ",", "and", "this", "product", "was", "also", "precipitated", "by", "the", "Hashimoto's", "sera"], "h": {"id": "C0021965", "name": "C0021965#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [15, 16]}}
{"token": ["A", "dopamine", "receptor", "C0304402#ent", "<e1>", "and", "a", "D1", "receptor", "agonist", "but", "not", "a", "C3850099#ent", "<e2>", "mimicked", "the", "effects", "of", "progesterone", "in", "facilitating", "sexual", "behavior", "female", "rats", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [13, 14]}}
{"token": ["Caffeine-treated", "rats", "were", "cross-tolerant", "to", "the", "locomotor", "C0304402#ent", "<e1>", "effect", "of", "these", "selective", "dopamine", "D1", "C3850099#ent", "<e2>"], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [15, 16]}}
{"token": ["Vasoactive", "intestinal", "peptide/PACAP", "receptor", "1", "VPAC1", ")", "and", "C1335867#ent", "<e1>", "present", ",", "whereas", "PACAP", "receptor", "1", "C1537486#ent", "<e2>", ")", "and", "CCK2", "receptors", "undetectable", "."], "h": {"id": "C1335867", "name": "C1335867#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1537486", "name": "C1537486#ent", "pos": [16, 17]}}
{"token": ["Heme", "and", "heme", "degrading", "enzymes", "namely", "C0018969#ent", "<e1>", "(", "HO", ")", "and", "C0053602#ent", "<e2>", "BR", ")", "were", "monitored", "in", "liver", "and", "spleen", "during", "Plasmodium", "berghei", "infection", "golden", "hamsters"], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0053602", "name": "C0053602#ent", "pos": [12, 13]}}
{"token": ["It", "was", "determined", "that", "C0018969#ent", "<e1>", "levels", "in", "umbilical", "cord", "blood", "platelets", "higher", ",", "whereas", "C0053602#ent", "<e2>", "levels", "were", "comparable", "with", "that", "found", "in", "platelets", "from", "adults", "."], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0053602", "name": "C0053602#ent", "pos": [15, 16]}}
{"token": ["Like", "PAK4", ",", "PAK6", "possesses", "a", "C0907533#ent", "<e1>", "basal", "kinase", "that", ",", "unlike", "C4084905#ent", "<e2>", ",", "is", "not", "modulated", "by", "the", "binding", "of", "active", "Rac", "or", "Cdc42", "GTPases", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [13, 14]}}
{"token": ["CPI-17", "was", "phosphorylated", "by", "GST-PKN-CAT", ",", "a", "C0907533#ent", "<e1>", "active", "GST-fusion", "fragment", "of", "C4084905#ent", "<e2>", ",", "to", "1.46", "mol", "of", "P/mol", "of", "CPI-17", ",", "in", "vitro"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "the", "C0907533#ent", "<e1>", "active", "55-kDa", "fragment", "of", "C4084905#ent", "<e2>", "does", "not", "contribute", "to", "apoptosis", ",", "but", "may", "contribute", "to", "a", "function", "of", "microglia/macrophages", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [11, 12]}}
{"token": ["C1425067#ent", "<e1>", "belongs", "to", "the", "RGK", "family", "of", "C0018296#ent", "<e2>", "members", "are", "known", "to", "interact", "with", "the", "voltage", "gated", "channel", "beta", "subunit", ",", "and", "to", "inhibit", "or", "abolish", "calcium", "currents"], "h": {"id": "C1425067", "name": "C1425067#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [8, 9]}}
{"token": ["Elevated", "levels", "of", "endogenous", "tissue-type", "plasminogen", "activator", "C0032143#ent", "<e1>", ")", "appear", "to", "be", "a", "marker", "for", "C0003850#ent", "<e2>"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [16, 17]}}
{"token": ["USA", "97:13830", "-", "13834", ";", "2000", ")", "showed", "that", "vitamin", "E", "deficiency", "by", "disruption", "of", "the", "alpha-tocopherol", "transfer", "protein", "gene", "C0032143#ent", "<e1>", ")", "is", "associated", "with", "modest", "increase", "in", "C0003850#ent", "<e2>", "in", "apolipoprotein", "E", "gene", "deficient", "Apoe(-/-", ")", ")", "mice", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [29, 30]}}
{"token": ["C1439284#ent", "<e1>", "endocytosis", "proceeds", "through", "clathrin-coated", "pits", "is", "independent", "of", "C0086376#ent", "<e2>", "predicts", "that", "the", "AngII-AT1", "receptor", "complex", "attains", "a", "conformation", "necessary", "for", "interaction", "with", "the", "endocytotic", "machinery", ",", "but", "separate", "from", "receptor", "signalling", "activation"], "h": {"id": "C1439284", "name": "C1439284#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["Clinically", ",", "the", "intense", "hypotonia", "with", "pyramidal", "tract", "signs", ",", "the", "absence", "of", "seizures", ",", "the", "C0740279#ent", "<e1>", "at", "the", "computerized", "tomography", "strongly", "the", "diagnosis", "of", "C0270724#ent", "<e2>"], "h": {"id": "C0740279", "name": "C0740279#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C0270724", "name": "C0270724#ent", "pos": [26, 27]}}
{"token": ["However", ",", "HSV-1", "and", "HSV-2", "C0011519#ent", "<e1>", "were", "also", "detected", "in", "C0004943#ent", "<e2>", "lesions", ",", "suggesting", "that", "HSV-1/2", "is", "not", "correlated", "to", "the", "direct", "pathogenesis", "of", "Beh\u00e7et's", "disease"], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [11, 12]}}
{"token": ["We", "propose", "that", "the", "interactions", "between", "C1332750#ent", "<e1>", ",", "a", "tissue-specific", "transcription", "factor", "and", "the", "broad-spectrum", "proteins", ",", "C1705628#ent", "<e2>", "and", "E2F1", ",", "are", "important", "in", "C/EBPepsilon-induced", "terminal", "granulocytic", "differentiation", "."], "h": {"id": "C1332750", "name": "C1332750#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "an", "C1706005#ent", "<e1>", "response", "mainly", "present", "in", "primary", "infections", "fusion", "proteins", "and", "C1824309#ent", "<e2>", ",", "again", "representing", "ppUL32", "and", "ppUL44", ",", "was", "found", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1824309", "name": "C1824309#ent", "pos": [15, 16]}}
{"token": ["Four", "patients", "had", "C0002514#ent", "<e1>", "and", "renal", "tubular", "acidosis", "two", "of", "four", "tested", "had", "C1704380#ent", "<e2>", "."], "h": {"id": "C0002514", "name": "C0002514#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704380", "name": "C1704380#ent", "pos": [14, 15]}}
{"token": ["C0751882#ent", "<e1>", "caused", "by", "different", "genetic", "defects", "C0086376#ent", "<e2>", "expressed", "at", "the", "neuromuscular", "junction"], "h": {"id": "C0751882", "name": "C0751882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}}
{"token": ["Heterozygosity", "for", "this", "postulated", "mutation", "(", "father", "of", "the", "patients", "with", "C0039730#ent", "<e1>", "may", "result", "in", "the", "production", "of", "a", "C0005283#ent", "<e2>", "carrier", "state", "with", "normal", "HbA2", "level", "."], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [20, 21]}}
{"token": ["We", "describe", "the", "cases", "of", "four", "children", "with", "aplastic", "crises", "in", "various", "types", "of", "C0039730#ent", "<e1>", "(", "alpha", "and", "C0005283#ent", "<e2>", "major", "and", "intermediate", "forms", "."], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [19, 20]}}
{"token": ["C0039730#ent", "<e1>", "common", "in", "Saudi", "Arabia", "the", "C0005283#ent", "<e2>", "with", "variable", "frequency", "in", "different", "regions", "of", "Saudi", "Arabia", "both", "B+", "and", "Bo", "thalassemia", "been", "reported", "."], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [7, 8]}}
{"token": ["To", "introduce", "a", "protocol", "for", "dissociative", "sedation", "C0022614#ent", "<e1>", "for", "children", "requiring", "C0030193#ent", "<e2>", "the", "emergency", "department"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}}
{"token": ["CONCLUSIONS", ":", "Both", "propofol", "and", "C0022614#ent", "<e1>", "provided", "safe", "and", "effective", "sedation", "for", "the", "short", ",", "C0030193#ent", "<e2>", "performed", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [16, 17]}}
{"token": ["The", "M-phase", "kinase", "cyclin", "B/Cdk1", "phosphorylates", "C1335589#ent", "<e1>", "efficiently", "in", "vitro", "and", "T409", "phosphorylation", "correlates", "with", "nuclear", "accumulation", "C1332695#ent", "<e2>", "in", "vivo"], "h": {"id": "C1335589", "name": "C1335589#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332695", "name": "C1332695#ent", "pos": [18, 19]}}
{"token": ["C0529793#ent", "<e1>", "may", "be", "considered", "as", "an", "alternative", "treatment", "in", "C0028705#ent", "<e2>", "there", "are", "several", "limitations", "to", "be", "overcome", "."], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028705", "name": "C0028705#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "the", "effect", "of", "C0529793#ent", "<e1>", "on", "the", "oesophageal", "motor", "function", "healthy", "subjects", "patients", "with", "C0028705#ent", "<e2>"], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028705", "name": "C0028705#ent", "pos": [16, 17]}}
{"token": ["C0071129#ent", "<e1>", ",", "2-hydroxymethyl-3-hydroxy-6-(1-hydroxy-2-tert-butylaminoethyl)pyridine", ",", "is", "a", "new", "C0001644#ent", "<e2>"], "h": {"id": "C0071129", "name": "C0071129#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [8, 9]}}
{"token": ["Using", "an", "in", "vitro", "prenylation", "screen", ",", "two", "human", "cDNAs", "(", "PTP(CAAXI", ")", "and", "C1335552#ent", "<e1>", ")", ")", "homologous", "to", "the", "rat", "C1335279#ent", "<e2>", "and", "human", "OV-1", "protein", "tyrosine", "phosphatase", "genes", "identified", "."], "h": {"id": "C1335552", "name": "C1335552#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335279", "name": "C1335279#ent", "pos": [22, 23]}}
{"token": ["Prospective", "studies", "creatine", "phosphokinase", "C3540772#ent", "<e1>", "should", "establish", "the", "frequency", "of", "rhabdomyolysis", "in", "C0042769#ent", "<e2>"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [13, 14]}}
{"token": ["Fourteen", "tumors", "with", "detectable", "NR4A3", "fusion", "genes", "C3274638#ent", "<e1>", ";", "TAF15-NR4A3", ")", "expressed", "neither", "native", "C1417837#ent", "<e2>", "nor", "SIX3", "."], "h": {"id": "C3274638", "name": "C3274638#ent", "pos": [7, 8]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1417837", "name": "C1417837#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "replacement", "of", "the", "ERK", "docking", "site", "C0248441#ent", "<e1>", "the", "p38", "MAPK", "docking", "site", "MAPKAPK2", "converts", "C0248441#ent", "<e1>", "a", "C0380241#ent", "<e1>", "in", "vivo"], "h": {"id": "C0248441", "name": "C0248441#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0380241", "name": "C0380241#ent", "pos": [20, 21]}}
{"token": ["Activation", "of", "P38", "SAPK", "to", "activation", "of", "C0248441#ent", "<e1>", "C0380241#ent", "<e2>", "and", "a", "major", "substrate", "protein", "C0248441#ent", "<e1>", "C0380241#ent", "<e2>", "is", "the", "small", "heat", "shock", "protein", "HSP27", "."], "h": {"id": "C0248441", "name": "C0248441#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0380241", "name": "C0380241#ent", "pos": [9, 10]}}
{"token": ["A", "C1412821#ent", "<e1>", "ORF", ")", "in", "C0032306#ent", "<e2>", "MVV", ")", "and", "caprine", "arthritis", "encephalitis", "virus", "CAEV", ")", "was", "initially", "named", "\"", "tat", "\"", "by", "analogy", "with", "a", "similarly", "placed", "ORF", "in", "the", "primate", "lentiviruses", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0032306", "name": "C0032306#ent", "pos": [6, 7]}}
{"token": ["In", "nine", "separate", "clinical", "trials", "382", "patients", "having", "symptoms", "of", "either", "prostatitis", ",", "acute", "cystitis", "C0041976#ent", "<e1>", ",", "and/or", "trigonitis", "were", "randomly", "assigned", "to", "treatment", "with", "C0016225#ent", "<e2>", "or", "phenazopyridine", "."], "h": {"id": "C0041976", "name": "C0041976#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0016225", "name": "C0016225#ent", "pos": [26, 27]}}
{"token": ["C0069737#ent", "<e1>", "was", "extensively", "metabolized", "and", "the", "unchanged", "C0013227#ent", "<e2>", "was", "undetectable", "in", "rat", "or", "human", "urine", ";", "only", "traces", "were", "found", "in", "dog", "urine", "."], "h": {"id": "C0069737", "name": "C0069737#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}}
{"token": ["The", "intracellular", "calcium", "level", "human", "keratinocytes", "was", "increased", "by", "incubation", "with", "C1442758#ent", "<e1>", ",", "but", "not", "with", "sphingosine", "(", "C1420041#ent", "<e2>", ")", "or", "sphingomyelin", "(", "SM", ")", "."], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420041", "name": "C1420041#ent", "pos": [19, 20]}}
{"token": ["Immunoprecipitation", "analysis", "that", "C1420314#ent", "<e1>", "prevented", "the", "suppression", "of", "C0246957#ent", "<e2>", "and", "Cdk2", ",", "but", "not", "the", "induction", "of", "p21", ",", "by", "TGF-beta1", "."], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0246957", "name": "C0246957#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "the", "reciprocally", "imprinted", "Meg3", "(", "C1418452#ent", "<e1>", "Gene", "3", ",", "found", "downstream", "of", "C1414069#ent", "<e2>", "in", "eutherian", "mammals", ",", "is", "absent", "in", "the", "opossum", "."], "h": {"id": "C1418452", "name": "C1418452#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414069", "name": "C1414069#ent", "pos": [15, 16]}}
{"token": ["In", "many", "serious", "diseases", "such", "as", "cancer", ",", "C0024437#ent", "<e1>", "age", "related", "macular", "degeneration", "cataract", ")", ",", "neurodegenerative", "diseases", "C0007758#ent", "<e2>", ",", "amyotrophic", "lateral", "sclerosis", "Alzheimer's", "disease", "stress", "is", "the", "factor", "original", "."], "h": {"id": "C0024437", "name": "C0024437#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [19, 20]}}
{"token": ["C1101145#ent", "<e1>", ",", "although", "homologous", "to", "viral", "and", "C0027803#ent", "<e2>", "displays", "a", "novel", "sialyltransferase", "activity", "is", "involved", "in", "host", "cell", "invasion"], "h": {"id": "C1101145", "name": "C1101145#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027803", "name": "C0027803#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "provide", "a", "systematic", "analysis", "Mycobacterium", "tuberculosis", "C1826313#ent", "<e1>", ")", "by", "directly", "C1456390#ent", "<e2>", "its", "gene", "products"], "h": {"id": "C1826313", "name": "C1826313#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1456390", "name": "C1456390#ent", "pos": [13, 14]}}
{"token": ["Complementation", "studies", "and", "allele", "replacement", "Saccharomyces", "cerevisiae", "that", "PSA1/VIG9", ",", "an", "essential", "gene", "encodes", "C1539585#ent", "<e1>", "is", "the", "wild-type", "C3540050#ent", "<e2>"], "h": {"id": "C1539585", "name": "C1539585#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540050", "name": "C3540050#ent", "pos": [19, 20]}}
{"token": ["Glucose", "could", "be", "measured", "with", "an", "C1826261#ent", "<e1>", "of", "1.30", "mM", "and", "an", "C1851585#ent", "<e2>", "of", "2.3", "%", "."], "h": {"id": "C1826261", "name": "C1826261#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1851585", "name": "C1851585#ent", "pos": [13, 14]}}
{"token": ["We", "currently", "studied", "neuroprotective", "properties", "a", "C3850105#ent", "<e1>", "LF16", "-", "0687", "Ms", ")", "in", "transitory", "C0917798#ent", "<e2>", "assess", "infarct", "formation", "and", "the", "development", "of", "brain", "edema"], "h": {"id": "C3850105", "name": "C3850105#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [15, 16]}}
{"token": ["The", "influence", "of", "the", "C3850105#ent", "<e1>", "on", "the", "cerebral", "microcirculation", "C0917798#ent", "<e2>", "investigated", "in", "a", "closed", "cranial", "window", "preparation", "in", "Mongolian", "gerbils", "by", "intravital", "fluorescence", "microscopy"], "h": {"id": "C3850105", "name": "C3850105#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "the", "cooperation", "between", "SF-1", "and", "Sp1", ",", "required", "for", "the", "regulation", "of", "C1413855#ent", "<e1>", ",", "is", "mediated", "by", "a", "direct", "protein-protein", "interaction", "the", "common", "C1422492#ent", "<e2>", "CBP", "."], "h": {"id": "C1413855", "name": "C1413855#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [26, 27]}}
{"token": ["C0014025#ent", "<e1>", "was", "utilized", "to", "inhibit", "angiotensin", "II", "C1424250#ent", "<e2>", ")", "formation", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [8, 9]}}
{"token": ["A", "hypothetical", "model", "of", "the", "C0021699#ent", "<e1>", ")", "protein", "of", "C3854222#ent", "<e2>", "HIV", ")", "is", "proposed", "that", "is", "derived", "from", "the", "known", "structure", "of", "the", "influenza", "TM", "protein", "HA2", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [10, 11]}}
{"token": ["The", "results", "indicate", "that", "C1420393#ent", "<e1>", "is", "rapidly", "induced", "in", "hepatocytes", "of", "intoxicated", "animals", "preceding", "C1417048#ent", "<e2>", "formation", "."], "h": {"id": "C1420393", "name": "C1420393#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [15, 16]}}
{"token": ["Using", "2D", "gel", "electrophoresis", "mass", "spectrometry", "we", "identified", "C1420393#ent", "<e1>", "as", "a", "novel", "C1417048#ent", "<e2>", "component", "."], "h": {"id": "C1420393", "name": "C1420393#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [13, 14]}}
{"token": ["A", "detailed", "study", "on", "the", "expression", "of", "C1420393#ent", "<e1>", "and", "its", "relationship", "to", "C1417048#ent", "<e2>", "formation", "in", "the", "3,5-diethoxycarbonyl-1,4-dihydrocollidine", "(DDC)-treated", "mouse", "liver", "is", "reported", "based", "on", "immunohistochemical", ",", "immunoblot", ",", "and", "Northern", "blot", "analyses"], "h": {"id": "C1420393", "name": "C1420393#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [13, 14]}}
{"token": ["The", "results", "indicate", "that", "C1420393#ent", "<e1>", "is", "involved", "in", "the", "mechanism", "of", "C1417048#ent", "<e2>", "formation", "."], "h": {"id": "C1420393", "name": "C1420393#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [12, 13]}}
{"token": ["A", "newly", "discovered", "property", "of", "hIIA", "C1706169#ent", "<e1>", "is", "the", "binding", "affinity", "for", "the", "heparan", "sulfate", "proteoglycan", "C2987155#ent", "<e2>", ")", "glypican-1", "."], "h": {"id": "C1706169", "name": "C1706169#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [17, 18]}}
{"token": ["The", "addition", "of", "heparin", "and", "the", "hydrolysis", "of", "C2987155#ent", "<e1>", "by", "heparinase", "III", "partially", "inhibited", "hIIA", "C1706169#ent", "<e2>", "binding", "to", "apoptotic", "cells", "suggesting", "an", "interaction", "with", "both", "C2987155#ent", "<e1>", "and", "other", "binding", "protein(s", ")", "."], "h": {"id": "C1706169", "name": "C1706169#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "report", "that", "murine", "erythroblasts", "released", "C3539526#ent", "<e1>", "in", "response", "to", "C0357126#ent", "<e2>", "and", "that", "C3539526#ent", "<e1>", "enhanced", "Epo", "receptor", "signaling", "by", "activating", "the", "serine-threonine", "kinase", "Akt", "these", "cells", "."], "h": {"id": "C3539526", "name": "C3539526#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0357126", "name": "C0357126#ent", "pos": [13, 14]}}
{"token": ["Onchocerciasis", ",", "or", "river", "blindness", "is", "a", "C0747256#ent", "<e1>", "by", "the", "filarial", "nematode", "C0029001#ent", "<e2>"], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0029001", "name": "C0029001#ent", "pos": [13, 14]}}
{"token": ["Six", "drugs", "in", "common", "use", "for", "the", "treatment", "of", "C0747256#ent", "<e1>", "man", "were", "given", "to", "18", "adult", "patients", "suffering", "from", "C0029001#ent", "<e2>", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0029001", "name": "C0029001#ent", "pos": [20, 21]}}
{"token": ["Onchocerciasis", "is", "a", "debilitating", "C0747256#ent", "<e1>", "by", "the", "C0029001#ent", "<e2>"], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0029001", "name": "C0029001#ent", "pos": [8, 9]}}
{"token": ["Inhibitors", "of", "C0138837#ent", "<e1>", "PFTIs", ")", "have", "been", "developed", "as", "C1516468#ent", "<e2>"], "h": {"id": "C0138837", "name": "C0138837#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1516468", "name": "C1516468#ent", "pos": [10, 11]}}
{"token": ["This", "paper", "reviews", "the", "antipsychotic", "and", "antimuscarinic", "potency", "of", "these", "drugs", "and", "compares", "the", "total", "C0003385#ent", "<e1>", "standard", "daily", "of", "antipsychotics", ",", "C0003405#ent", "<e2>", "antidepressants", "."], "h": {"id": "C0003385", "name": "C0003385#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [22, 23]}}
{"token": ["Clozapine", "was", "associated", "with", "higher", "C0003385#ent", "<e1>", "other", "antipsychotics", "or", "low", "doses", "C0003405#ent", "<e2>", "."], "h": {"id": "C0003385", "name": "C0003385#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [12, 13]}}
{"token": ["Among", "the", "tested", "isoenzymes", ",", "P450", "2B6", "C0960580#ent", "<e1>", "P450", "2D6", "and", "P450", "3A4", "PCEPA", "O-deethylation", ",", "and", "P450", "2B6", "C0960580#ent", "<e1>", "and", "P450", "2D6", "catalyzed", "C0008249#ent", "<e1>", "O-demethylation", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008249", "name": "C0008249#ent", "pos": [26, 27]}}
{"token": ["The", "molecular", "weights", "the", "enzymes", "are", "24.5", "-", "26", "C1839259#ent", "<e1>", "for", "the", "C0030306#ent", "<e2>", "and", "23.5", "-", "25.5", "C1839259#ent", "<e1>", "for", "the", "cathepsin", "G.", "cathepsin", "G", "a", "glycoprotein", ",", "while", "the", "elastase", "molecule", "carbohydrate", "components"], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [13, 14]}}
{"token": ["C0256103#ent", "<e1>", "treated", "U937", "monoblastoid", "cells", "expressed", "C1424965#ent", "<e2>", ",", "hypophosphorylated", "retinoblastoma", "protein", "(", "Rb", ")", ",", "arrested", "in", "G(1", ")", "and", "differentiated", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424965", "name": "C1424965#ent", "pos": [7, 8]}}
{"token": ["C0256103#ent", "<e1>", "treated", "PKC-zeta", "cells", "express", "C1424965#ent", "<e2>", "and", "display", "substantial", "hypophosphorylation", "of", "Rb", "but", "fail", "to", "arrest", "in", "G(1", ")", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424965", "name": "C1424965#ent", "pos": [6, 7]}}
{"token": ["These", "results", "indicate", "that", "bovine", "heart", "atrial", "natriuretic", "fractions", "decrease", "the", "sodium", "potential", "C1425409#ent", "<e1>", ")", ",", "sodium", "conductance", "(", "C1366550#ent", "<e2>", ")", "and", "passive", "conductance", "(", "Gsh", ")", "."], "h": {"id": "C1425409", "name": "C1425409#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366550", "name": "C1366550#ent", "pos": [20, 21]}}
{"token": ["The", "48-kD", "protein", "kinase", "was", "identified", "as", "C1706138#ent", "<e1>", "(", "salicylic", "acid-induced", "protein", "kinase", ",", "a", "member", "of", "the", "C0752312#ent", "<e2>", "mitogen-activated", "protein", "kinase", "family", "that", "is", "activated", "by", "various", "other", "stress", "stimuli"], "h": {"id": "C1706138", "name": "C1706138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [19, 20]}}
{"token": ["The", "results", "indicate", "that", "inhibition", "of", "C0001044#ent", "<e1>", "in", "the", "gastrointestinal", "tract", "certain", "C0008425#ent", "<e2>", "be", "involved", "in", "the", "behavioral", "effects", "attributed", "to", "these", "drugs", "."], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [13, 14]}}
{"token": ["A", "C0001044#ent", "<e1>", "pregnant", "women", "more", "consistent", "with", "possible", "overexposure", "to", "C0008425#ent", "<e2>", "than", "a", "low", "plasma", "cholinesterase", "."], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [11, 12]}}
{"token": ["Other", "C0206064#ent", "<e1>", "also", "cause", "C0002962#ent", "<e2>", "may", "be", "difficult", "to", "differentiate", "from", "atherosclerotic", "CAD", "."], "h": {"id": "C0206064", "name": "C0206064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [5, 6]}}
{"token": ["C0206064#ent", "<e1>", "defined", "as", "C0002962#ent", "<e2>", "by", "objective", "signs", "of", "ischemia", "on", "exercise", "testing", "myocardial", "scintigraphy", "but", "with", "angiographically", "\"", "normal", "\"", "coronary", "arteries"], "h": {"id": "C0206064", "name": "C0206064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [4, 5]}}
{"token": ["Here", "we", "show", "that", "an", "extragenic", "suppressor", "C1425569#ent", "<e1>", ",", "Su(Raf)1", ",", "encodes", "a", "Drosophila", "C0038085#ent", "<e2>", "."], "h": {"id": "C1425569", "name": "C1425569#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [15, 16]}}
{"token": ["To", "evaluate", "the", "effect", "of", "C0526501#ent", "<e1>", ",", "a", "selective", "5-hydroxytryptamine-4", "C0243192#ent", "<e2>", ",", "on", "esophageal", "motility", "bolus", "transit", "in", "asymptomatic", "volunteers", "."], "h": {"id": "C0526501", "name": "C0526501#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}}
{"token": ["Mosapride", "citrate", "C0526501#ent", "<e1>", ")", "is", "a", "serotonin", "5-hydroxytryptamine", "4", "receptor", "C0243192#ent", "<e2>", "known", "to", "promote", "gastric", "emptying", "large-intestine", "motility", "."], "h": {"id": "C0526501", "name": "C0526501#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "the", "mutant", "forms", "show", "an", "11", "-", "22-fold", "increase", "in", "rates", "of", "GDP", "dissociation", "from", "C1705442#ent", "<e1>", "compared", "with", "the", "C1883559#ent", "<e2>"], "h": {"id": "C1705442", "name": "C1705442#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [22, 23]}}
{"token": ["The", "biochemical", "pathway", "which", "this", "organism", "converts", "4-chlorobenzoate", "to", "C0000500#ent", "<e1>", "consists", "of", "three", "C3540790#ent", "<e2>", ":", "4-chlorobenzoyl-CoA", "ligase", ",", "4-chlorobenzoyl-CoA", "dehalogenase", ",", "and", "4-hydroxybenzoyl-CoA", "thioesterase"], "h": {"id": "C0000500", "name": "C0000500#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [14, 15]}}
{"token": ["Genetic", "variants", "C0017337#ent", "<e1>", "for", "peptide", "YY", "PYY", ")", ",", "C1417817#ent", "<e2>", "NPY2R", ")", "and", "pancreatic", "polypeptide", "PPY", ")", "were", "investigated", "for", "association", "with", "severe", "obesity", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417817", "name": "C1417817#ent", "pos": [10, 11]}}
{"token": ["C0061330#ent", "<e1>", "further", "inhibited", "by", "C3494348#ent", "<e2>", "of", "the", "hepatocellular", "monocarboxylate", "transporter", "by", "the", "loop", "diuretic", "bumetanide", "by", "4,4'-diisothiocyano-2,2'-stilbenedisulfonate", "(", "DIDS", ")", "and", "by", "sulfate", "."], "h": {"id": "C0061330", "name": "C0061330#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [5, 6]}}
{"token": ["Thus", ",", "gonadotropin", "(", "RIA", ")", "determinations", "before", "versus", "during", "an", "acute", "course", "of", "C2936882#ent", "<e1>", "and", "progesterone", "therapy", "distinguish", "C0085215#ent", "<e2>", "the", "presence", "of", "circulating", "anti-gonadotropin", "antibodies", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085215", "name": "C0085215#ent", "pos": [20, 21]}}
{"token": ["The", "bilirubinemia", "in", "this", "horse", "appears", "most", "similar", "to", "a", "C1306792#ent", "<e1>", "caused", "by", "a", "familial", "deficiency", "C0041560#ent", "<e2>"], "h": {"id": "C1306792", "name": "C1306792#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041560", "name": "C0041560#ent", "pos": [17, 18]}}
{"token": ["A", "yeast", "two-hybrid", "screen", "C1422049#ent", "<e1>", "as", "bait", "identified", "calcium-modulating", "cyclophilin", "ligand", "C1707071#ent", "<e2>", ")", "as", "an", "C1422049#ent", "<e1>", "partner", "."], "h": {"id": "C1422049", "name": "C1422049#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1707071", "name": "C1707071#ent", "pos": [12, 13]}}
{"token": ["ORF1", "encodes", "the", "putative", "viral", "polymerase", "(", "RdRp", ")", ",", "C0341703#ent", "<e1>", "4", "the", "triple", "gene", "block", "(", "C1705594#ent", "<e2>", "1", "-", "3", ")", ",", "and", "ORF5-coat", "protein", "CP", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705594", "name": "C1705594#ent", "pos": [18, 19]}}
{"token": ["In", "the", "present", "study", "we", "show", "that", "clinical", "episodes", "P.", "falciparum", "C0024530#ent", "<e1>", "produced", "an", "increase", "in", "plasma", "levels", "soluble", "C1706544#ent", "<e2>", "(", "sICAM-1", ")", "and", "ELAM-1", "(", "sELAM-1", ")", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [20, 21]}}
{"token": ["Adhesion", "of", "IRBC", "from", "Thai", "patients", "with", "uncomplicated", "and", "severe", "falciparum", "C0024530#ent", "<e1>", "to", "purified", "CD36", "or", "C1706544#ent", "<e2>", "and", "to", "C32", "melanoma", "cells", "was", "compared", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [17, 18]}}
{"token": ["Parasites", "from", "children", "with", "severe", "C0024530#ent", "<e1>", "anemia", "bound", "least", "to", "CD36", ",", "whereas", "C1706544#ent", "<e2>", "binding", "was", "lowest", "in", "children", "with", "cerebral", "malaria"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [14, 15]}}
{"token": ["These", "data", "indicate", "that", "the", "gastrointestinal", "nematodes", "including", "Haemonchus", "contortus", "may", "have", "developed", "more", "resistance", "to", "C0733383#ent", "<e1>", "and", "morantel", "than", "to", "C0015821#ent", "<e2>", "."], "h": {"id": "C0733383", "name": "C0733383#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0015821", "name": "C0015821#ent", "pos": [22, 23]}}
{"token": ["PPP2R2B", "encodes", "Bbeta1", "and", "C3273872#ent", "<e1>", ",", "alternatively", "spliced", "and", "C1880904#ent", "<e2>", "regulatory", "subunits", "of", "the", "protein", "phosphatase", "2A", "PP2A", ")", "holoenzyme", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [10, 11]}}
{"token": ["Maternal", "infections", "rubella", "virus", "cytomegalovirus++", ",", "C0019159#ent", "<e1>", ",", "Coxsackie", "B", "varicella", ",", "herpes", ",", "C0032371#ent", "<e2>", ",", "parvovirus", "B19", "HIV", "are", "discussed", "stressing", "their", "unfavourable", "effect", "on", "the", "developing", "embryo", "fetus", "or", "newborn", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032371", "name": "C0032371#ent", "pos": [15, 16]}}
{"token": ["C0001044#ent", "<e1>", "was", "labeled", "with", "C0052451#ent", "<e2>", ",", "a", "compound", "which", "diethylphosphorylates", "C0001044#ent", "<e1>", "at", "its", "active", "site"], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0052451", "name": "C0052451#ent", "pos": [5, 6]}}
{"token": ["Tryptic", "digests", "purified", "recombinant", "mouse", "C0001044#ent", "<e1>", "(", "mAChE", ")", "were", "fractionally", "inhibited", "by", "C0052451#ent", "<e2>", "to", "form", "diethyl", "phosphoryl", "enzyme", "."], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0052451", "name": "C0052451#ent", "pos": [14, 15]}}
{"token": ["This", "C0033740#ent", "<e1>", "first", "thought", "to", "be", "C0040558#ent", "<e2>", "but", "immunoperoxidase", "staining", "large", "numbers", "of", "Sarcocystis", "canis"], "h": {"id": "C0033740", "name": "C0033740#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0040558", "name": "C0040558#ent", "pos": [7, 8]}}
{"token": ["Similarly", ",", "a", "combination", "of", "the", "C2936662#ent", "<e1>", "baicalein", "(", "10", "microM", ")", "and", "the", "C1289971#ent", "<e2>", "[", "6-[3-fluoro-5-[4-methoxy-3,4,5,6-tetrahydro-2H-pyran-4-yl])phenoxy-methyl]-1-methyl-2-quinolone", "]", "(", "10", "microM", ")", "caused", "significant", "inhibition", "of", "bradykinin-induced", "responses", "."], "h": {"id": "C2936662", "name": "C2936662#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1289971", "name": "C1289971#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "effect", "of", "C0059438#ent", "<e1>", "(", "EGCG", ")", "on", "acute", "lung", "injury", "induced", "by", "C0028928#ent", "<e2>", "mice", "and", "the", "possible", "mechanism", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [16, 17]}}
{"token": ["C0006992#ent", "<e1>", "was", "not", "carboxylated", "when", "substituted", "for", "C1333713#ent", "<e2>", "in", "a", "peptide", "containing", "Asp7", "."], "h": {"id": "C0006992", "name": "C0006992#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333713", "name": "C1333713#ent", "pos": [8, 9]}}
{"token": ["These", "results", "document", "changes", "in", "both", "size", "and", "charge", "of", "the", "mutant", "C3540790#ent", "<e1>", "from", "patients", "with", "different", "mutations", "and", "C0023522#ent", "<e2>", "subtypes", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023522", "name": "C0023522#ent", "pos": [20, 21]}}
{"token": ["In", "chronic", "renal", "failure", "the", "oral", "agents", "that", "can", "be", "used", "therefore", "include", "the", "insulin", "secretagogues", "repaglinide", "and", "C0903898#ent", "<e1>", "and", "the", "C3541957#ent", "<e2>", "(", "rosiglitazone", "and", "pioglitazone", ")", "with", "caution", "."], "h": {"id": "C0903898", "name": "C0903898#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3541957", "name": "C3541957#ent", "pos": [22, 23]}}
{"token": ["Treating", "C0014547#ent", "<e1>", "patients", "at", "primary", "level", "C0031412#ent", "<e2>", "will", "increase", "the", "treatment", "coverage", "and", "reduce", "treatment", "costs"], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [7, 8]}}
{"token": ["The", "authors", "report", "osteomalacia", "in", "3", "cases", "of", "C0014547#ent", "<e1>", "and", "one", "case", "of", "coronary", "heart", "disease", "treated", "with", "C0031412#ent", "<e2>", ",", "either", "alone", "or", "associated", "with", "anticonvulsants", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [19, 20]}}
{"token": ["Clinical", "signs", "C1412446#ent", "<e1>", "were", "absent", "in", "all", "patients", "with", "a", "positive", "C1705981#ent", "<e2>", "."], "h": {"id": "C1412446", "name": "C1412446#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705981", "name": "C1705981#ent", "pos": [12, 13]}}
{"token": ["Since", "the", "C0298973#ent", "<e1>", "ATM", ")", "gene", "is", "required", "for", "IR-induced", "activation", "of", "C1706047#ent", "<e2>", ",", "it", "has", "been", "assumed", "that", "ATM", "and", "C1706047#ent", "<e2>", "act", "in", "a", "linear", "pathway", "to", "p53", "activation", "."], "h": {"id": "C0298973", "name": "C0298973#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706047", "name": "C1706047#ent", "pos": [13, 14]}}
{"token": ["In", "a", "comparison", "with", "patients", "of", "younger", "age", "groups", "it", "appeared", "that", "amyloidosis", ",", "C0086445#ent", "<e1>", "vasculitis", "and", "C0011849#ent", "<e2>", "had", "a", "significantly", "higher", "incidence", "in", "the", "elderly", "."], "h": {"id": "C0086445", "name": "C0086445#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "case", "of", "C0154307#ent", "<e1>", "IPH", ")", "in", "association", "with", "C0677607#ent", "<e2>", "in", "a", "39", "year", "old", "woman", "."], "h": {"id": "C0154307", "name": "C0154307#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [12, 13]}}
{"token": ["Monotherapy", "with", "calcium", "antagonists", "nifedipine", ",", "foridon", "and", "C0700468#ent", "<e1>", "assessed", "in", "46", "patients", "with", "chronic", "glomerulonephritis", "C0020538#ent", "<e2>", "hypotensive", "effect", "and", "changes", "in", "systemic", "and", "renal", "hemodynamics", "water-electrolytic", "balance", "renin-angiotensin", "system"], "h": {"id": "C0700468", "name": "C0700468#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [17, 18]}}
{"token": ["C2936824#ent", "<e1>", "PI3K", "are", "a", "group", "of", "C4284029#ent", "<e2>", "phosphorylate", "phosphoinositides", "at", "the", "3-hydroxyl", "group", "the", "inositol", "ring", "generate", "phosphatidylinositol", "3,4,5-trisphosphate", "a", "second", "messenger", "with", "key", "roles", "in", "fundamental", "cellular", "responses", "as", "cell", "proliferation", "metabolism", "."], "h": {"id": "C2936824", "name": "C2936824#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4284029", "name": "C4284029#ent", "pos": [7, 8]}}
{"token": ["The", "C1428159#ent", "<e1>", "pi", "was", "the", "most", "abundant", "C3888277#ent", "<e2>", ",", "and", "was", "detected", "in", "all", "B", "and", "T", "cell", "."], "h": {"id": "C1428159", "name": "C1428159#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3888277", "name": "C3888277#ent", "pos": [8, 9]}}
{"token": ["Rebamipide", "significantly", "downregulates", "in", "C0796126#ent", "<e1>", "cell", "survivin", "expression", ",", "its", "association", "with", "C1420464#ent", "<e2>", "and", "cell", "proliferation"], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420464", "name": "C1420464#ent", "pos": [13, 14]}}
{"token": ["We", "then", "used", "these", "recombinant", "C.", "pneumoniae", "proteins", "purified", "C.", "pneumoniae", "bodies", "as", "antigens", "in", "enzyme", "immunoassays", "assess", "the", "kinetics", "and", "C1420333#ent", "<e1>", "the", "systemic", "and", "mucosal", "antibody", "responses", "induced", "by", "C.", "pneumoniae", "C0948075#ent", "<e2>", "BALB/c", "mice"], "h": {"id": "C1420333", "name": "C1420333#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0948075", "name": "C0948075#ent", "pos": [33, 34]}}
{"token": ["Adenosine", "agonists", "be", "expected", "to", "have", "sedative", ",", "anticonvulsant", "and", "C0040616#ent", "<e1>", "actions", "whereas", "C2936569#ent", "<e2>", "as", "caffeine", "have", "stimulant", "and", "anxiogenic", "properties", "."], "h": {"id": "C0040616", "name": "C0040616#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2936569", "name": "C2936569#ent", "pos": [14, 15]}}
{"token": ["C0020538#ent", "<e1>", "a", "major", "cardiovascular", "risk", "factor", "leads", "to", "vascular", "as", "well", "as", "C0029166#ent", "<e2>", "coronary", "artery", "disease", "hypertensive", "microvascular", "disease", "concentric", "left", "ventricular", "hypertrophy", "well", "as", "perivascular", "and", "interstitial", "fibrosis"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [13, 14]}}
{"token": ["A", "new", "multispectral", "(", "C0026269#ent", "<e1>", ")", "approach", "is", "described", "to", "characterize", "C0917798#ent", "<e2>", "a", "time-independent", "fashion", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [12, 13]}}
{"token": ["We", "further", "established", "that", "both", "transient", "and", "C0907533#ent", "<e1>", "HRT1", "signaling", "promoted", "VSMC", "survival", "in", "response", "to", "serum", "deprivation", "C1335191#ent", "<e2>", "Fas", "ligand", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335191", "name": "C1335191#ent", "pos": [19, 20]}}
{"token": ["Consistent", "with", "survival-promoting", "role", "of", "Akt", ",", "we", "observed", "that", "C0907533#ent", "<e1>", "activated", "Akt", "(", "Myr-Akt", ")", "inhibited", "apoptosis", "of", "C1335191#ent", "<e2>", ",", "c-Myc-overexpressing", "cells", "following", "the", "inhibition", "of", "EGFR", "tyrosine", "kinase", "activity"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335191", "name": "C1335191#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "C1423923#ent", "<e1>", "is", "a", "translationally", "regulated", "C1336849#ent", "<e2>", "is", "frequently", "overexpressed", "in", "different", "forms", "of", "cancer", "."], "h": {"id": "C1423923", "name": "C1423923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336849", "name": "C1336849#ent", "pos": [9, 10]}}
{"token": ["We", "then", "examined", "cytocine", "methylation", "in", "hCG", "alpha", "beta", "and", "C3538683#ent", "<e1>", "genes", "using", "methylation", "sensitive", "(", "Hha", "I", "C1367469#ent", "<e2>", "and", "non", "sensitive", "Msp", "I", "restriction", "enzymes", "and", "molecular", "hybridization"], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "demonstrate", "that", "in", "hypertensive", "patients", "with", "C0011860#ent", "<e1>", "short-term", "treatment", "with", "C0646101#ent", "<e2>", "is", "neutral", "to", "insulin", "sensitivity", "lipoprotein", "metabolism", "and", "fibrinogen", ",", "and", "significantly", "reduces", "microalbuminuria", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0646101", "name": "C0646101#ent", "pos": [13, 14]}}
{"token": ["The", "C0339143#ent", "<e1>", "disappeared", ",", "and", "the", "patient", "did", "not", "develop", "C1260880#ent", "<e2>", "or", "any", "other", "side", "effects", "treatment", "with", "cabergoline", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [11, 12]}}
{"token": ["These", "preclinical", "research", "studies", "the", "basis", "for", "future", "preclinical", "studies", "clinical", "development", "C0911587#ent", "<e1>", "as", "a", "new", "C3537104#ent", "<e2>", "candidate", "."], "h": {"id": "C0911587", "name": "C0911587#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3537104", "name": "C3537104#ent", "pos": [17, 18]}}
{"token": ["N'-[2-(2-Thiophene)ethyl]-N'-[2-(5bromopyridyl)]thiourea", "(", "CAS", "258340", "-", "15", "-", "7", ",", "C0911587#ent", "<e1>", ")", "is", "a", "potent", "non-nucleoside", "inhibitor", "HIV", "reverse", "transcriptase", "C3537104#ent", "<e2>", ")", "that", "was", "rationally", "designed", "as", "a", "candidate", "anti-HIV", "agent"], "h": {"id": "C0911587", "name": "C0911587#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3537104", "name": "C3537104#ent", "pos": [20, 21]}}
{"token": ["The", "lipoxygenase", "inhibitor", "nordihydroguaiaretic", "acid", "NDGA", ")", ",", "the", "dual", "lipoxygenase", "C1257954#ent", "<e1>", "tolfenamic", "acid", "the", "C1257954#ent", "<e1>", "indomethacin", "as", "well", "as", "C0040979#ent", "<e1>", "retained", "their", "inhibitory", "activity"], "h": {"id": "C1257954", "name": "C1257954#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [22, 23]}}
{"token": ["Topical", "treatment", "gastric", "mucosa", "C0006931#ent", "<e1>", "(", "cap", ")", "increases", "gastric", "mucosal", "blood", "flow", "C3539706#ent", "<e2>", ")", "and", "protects", "the", "mucosa", "from", "injury", "by", "acidified", "bile", "salts"], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539706", "name": "C3539706#ent", "pos": [14, 15]}}
{"token": ["C1413930#ent", "<e1>", "DCN", ")", "is", "an", "antiadhesive", "dermatan", "sulfate-rich", "proteoglycan", "interacts", "with", "C1710292#ent", "<e2>", "(", "TSP", ")", "and", "inhibits", "fibroblast", "adhesion", "TSP", "[", "Winnem\u00f6ller", "et", "al.", ",", "1992", "]", "."], "h": {"id": "C1413930", "name": "C1413930#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1710292", "name": "C1710292#ent", "pos": [12, 13]}}
{"token": ["Complementation", "cloning", "the", "C1100708#ent", "<e1>", "genes", "revealed", "identity", "of", "DIM1", "to", "C1710643#ent", "<e2>", "and", "DIM2", "to", "PAN1", "."], "h": {"id": "C1100708", "name": "C1100708#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1710643", "name": "C1710643#ent", "pos": [11, 12]}}
{"token": ["Chest", "pain", "associated", "with", "C0151744#ent", "<e1>", "occur", "after", "C0075632#ent", "<e2>", "administration", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0075632", "name": "C0075632#ent", "pos": [8, 9]}}
{"token": ["Cases", "have", "been", "published", "of", "coronary", "vasospasm", "C0151744#ent", "<e1>", "and", "myocardial", "infarction", "after", "C0075632#ent", "<e2>", "use", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0075632", "name": "C0075632#ent", "pos": [13, 14]}}
{"token": ["It", "produces", "a", "dose", "dependent", "inhibition", "of", "the", "gastric", "mucosal", "damage", "induced", "by", "pyloric", "ligation", "hypothermic", "restraint", "stress", "NSAIDs", ",", "reserpine", ",", "C0058185#ent", "<e1>", "and", "cytodestructing", "agents", "and", "that", "of", "C0013295#ent", "<e2>", "induced", "by", "cysteamine", "."], "h": {"id": "C0058185", "name": "C0058185#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [30, 31]}}
{"token": ["To", "investigate", "the", "role", "of", "CRH", "in", "the", "plasma", "ACTH", "response", "to", "C0020615#ent", "<e1>", ",", "two", "different", "doses", "of", "C1705056#ent", "<e2>", "oCRH", ")", "were", "given", "to", "normal", "men", "during", "insulin-induced", "hypoglycemia"], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705056", "name": "C1705056#ent", "pos": [19, 20]}}
{"token": ["Two", "previously", "unevaluated", "selenium", "compounds", "C0961842#ent", "<e1>", "(", "ASC", ")", "and", "Se-propylselenocysteine", "(", "C0566602#ent", "<e2>", ")", ",", "have", "been", "shown", "recently", "to", "be", "active", "in", "the", "chemoprevention", "of", "experimentally", "induced", "mammary", "carcinogenesis"], "h": {"id": "C0961842", "name": "C0961842#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [13, 14]}}
{"token": ["To", "explore", "the", "role", "of", "C3640117#ent", "<e1>", "C1422049#ent", "<e2>", ")", "in", "vascular", "remodeling", "we", "developed", "transgenic", "mice", "mouse", "C1422049#ent", "<e2>", "cDNA", "and", "examined", "remodeling", "after", "inflammatory", "vascular", "injury", "induced", "by", "polyethylene", "cuff", "placement", "."], "h": {"id": "C3640117", "name": "C3640117#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1422049", "name": "C1422049#ent", "pos": [7, 8]}}
{"token": ["Recent", "work", "with", "transgenic", "mice", "overexpressing", "the", "C0085151#ent", "<e1>", "that", "anti-Abeta", "antibodies", "clearance", "of", "the", "C2362547#ent", "<e2>", "the", "brain", "and", "reduce", "plaque", "burden", "."], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2362547", "name": "C2362547#ent", "pos": [15, 16]}}
{"token": ["Living", "organisms", "to", "build", "up", "mechanisms", "to", "protect", "themselves", "against", "oxidative", "stress", "with", "enzymes", "such", "as", "catalase", "and", "superoxide", "dismutase", "C0751984#ent", "<e1>", "thioredoxin", "and", "C0061505#ent", "<e2>", ",", "and", "molecules", "such", "as", "glutathione", "."], "h": {"id": "C0751984", "name": "C0751984#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0061505", "name": "C0061505#ent", "pos": [24, 25]}}
{"token": ["In", "result", "of", "pharmacological", "investigations", "which", "showed", "C0003195#ent", "<e1>", "substance", "3-carbethoxyamino-5-dimethylaminoacetyl-10,11-Dihydro-5H-dib", "enz[b", ",", "f]azepine", "X", "HCl", "(", "C1705766#ent", "<e2>", "015", ",", "AWD", "19", "-", "166", ",", "Bonnecor", ")", "was", "selected", "for", "clinical", "tests"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705766", "name": "C1705766#ent", "pos": [17, 18]}}
{"token": ["The", "patients", "were", "middle-aged", "women", "with", "a", "long", "history", "C0011616#ent", "<e1>", "had", "used", "C0304604#ent", "<e2>", "years", "."], "h": {"id": "C0011616", "name": "C0011616#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0304604", "name": "C0304604#ent", "pos": [13, 14]}}
{"token": ["The", "metabolism", "of", "C2239920#ent", "<e1>", "(", "a", ")", "seems", "to", "be", "primarily", "influenced", "by", "C3540725#ent", "<e2>", ",", "which", "rapidly", "decrease", "C2239920#ent", "<e1>", "(", "a", ")", "concentrations", "."], "h": {"id": "C2239920", "name": "C2239920#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "the", "effect", "of", "prolonged", "C1705323#ent", "<e1>", "inhibition", "on", "inflammatory", "profile", "endothelial", "function", "patients", "with", "ischemic", "heart", "disease", "high", "serum", "C-reactive", "protein", "C1413766#ent", "<e2>", ")", "values", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413766", "name": "C1413766#ent", "pos": [23, 24]}}
{"token": ["Renal", "cortex", "mRNA", "was", "isolated", "for", "determination", "of", "C1705323#ent", "<e1>", ",", "eNOS", ",", "and", "C1413766#ent", "<e2>", "mRNA", "by", "real-time", "reverse-transcriptase", "polymerase", "chain", "reaction"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413766", "name": "C1413766#ent", "pos": [14, 15]}}
{"token": ["Hence", ",", "in", "C1705694#ent", "<e1>", ",", "the", "effects", "of", "fenofibrate", "on", "plasma", "lipid", "transfer", "protein", ",", "especially", "C1455838#ent", "<e2>", "activity", ",", "may", "partially", "explain", "the", "associated", "changes", "in", "apoB", "kinetics", "."], "h": {"id": "C1705694", "name": "C1705694#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1455838", "name": "C1455838#ent", "pos": [17, 18]}}
{"token": ["We", "report", "two", "female", "patients", "with", "C0042994#ent", "<e1>", "developed", "hirsutism", "after", "treatment", "with", "C3219108#ent", "<e2>"], "h": {"id": "C0042994", "name": "C0042994#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3219108", "name": "C3219108#ent", "pos": [13, 14]}}
{"token": ["TEN", "differed", "from", "SSSS", "by", "both", "the", "absence", "of", "C3538869#ent", "<e1>", "+", "granulocytes", "and", "a", "stronger", "expression", "of", "the", "C1335191#ent", "<e2>", "CD95", "antigen", "the", "epidermis", "."], "h": {"id": "C3538869", "name": "C3538869#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335191", "name": "C1335191#ent", "pos": [19, 20]}}
{"token": ["Little", "change", "was", "found", "in", "the", "EEGs", "of", "C1112466#ent", "<e1>", "subjects", "after", "chocolate", "or", "C0070559#ent", "<e2>", "."], "h": {"id": "C1112466", "name": "C1112466#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0070559", "name": "C0070559#ent", "pos": [14, 15]}}
{"token": ["The", "N-terminal", "60-kDa-fragment", "of", "C1414295#ent", "<e1>", "rat", "liver", "(", "C0059037#ent", "<e2>", ")", "was", "obtained", "by", "the", "limited", "proteolysis", "of", "native", "C0059037#ent", "<e2>", "with", "elastase", "."], "h": {"id": "C1414295", "name": "C1414295#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [9, 10]}}
{"token": ["The", "ADP-ribosylation", "of", "C1414295#ent", "<e1>", "C0059037#ent", "<e2>", ")", "in", "vitro", "used", "to", "quantitate", "C0059037#ent", "<e2>", "and", "to", "determine", "its", "subcellular", "distribution", "in", "extracts", "of", "Artemia", "embryos", "at", "different", "stages", "of", "development", "."], "h": {"id": "C1414295", "name": "C1414295#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [5, 6]}}
{"token": ["Clinical", "examination", "a", "C0025309#ent", "<e1>", "diagnosed", "as", "C0041296#ent", "<e2>", "."], "h": {"id": "C0025309", "name": "C0025309#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [7, 8]}}
{"token": ["C0431375#ent", "<e1>", "LIS", ")", "and", "subcortical", "band", "heterotopia", "C1848201#ent", "<e2>", ")", "are", "related", "cortical", "malformations", "to", "abnormal", "migration", "of", "neurons", "during", "early", "brain", "development"], "h": {"id": "C0431375", "name": "C0431375#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C1848201", "name": "C1848201#ent", "pos": [8, 9]}}
{"token": ["C0030360#ent", "<e1>", "PLS", ")", "is", "described", "as", "the", "association", "of", "C0022596#ent", "<e2>", "precocious", "periodontal", "disease", "results", "in", "exfoliation", "of", "primary", "and", "permanent", "dentitions"], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0022596", "name": "C0022596#ent", "pos": [10, 11]}}
{"token": ["A", "single", "injection", "of", "nicotine", "C2697645#ent", "<e1>", "increased", "the", "C1706383#ent", "<e2>", "mRNA", "content", "within", "30", "min", "and", "returned", "toward", "baseline", "by", "120", "min", "."], "h": {"id": "C2697645", "name": "C2697645#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [9, 10]}}
{"token": ["One", "of", "the", "cDNAs", "identified", "encoded", "the", "C1413746#ent", "<e1>", ",", "originally", "identified", "as", "a", "C0079556#ent", "<e2>", "Tax", "responsive", "element", "binding", "protein", "."], "h": {"id": "C1413746", "name": "C1413746#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079556", "name": "C0079556#ent", "pos": [14, 15]}}
{"token": ["As", "there", "have", "been", "a", "few", "reports", "of", "patients", "with", "C0022735#ent", "<e1>", "association", "with", "skeletal", "muscular", "diseases", "as", "Becker-type", "muscular", "dystrophy", "C3250443#ent", "<e2>", "the", "gene", "mutation", "causes", "C0022735#ent", "<e1>", "occur", "in", "the", "cardiac", "muscle"], "h": {"id": "C0022735", "name": "C0022735#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3250443", "name": "C3250443#ent", "pos": [21, 22]}}
{"token": ["C1257954#ent", "<e1>", "treatment", "also", "reduced", "the", "levels", "of", "anti-apoptotic", "proteins", "C0376515#ent", "<e2>", "and", "Mcl-1", "and", "increased", "the", "levels", "of", "the", "pro-apoptotic", "protein", "bax", "."], "h": {"id": "C1257954", "name": "C1257954#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [10, 11]}}
{"token": ["Administration", "of", "typical", "antipsychotic", "drugs", "C0043603#ent", "<e1>", ")", "is", "often", "accompanied", "by", "extrapyramidal", "side-effects", "(", "C1868684#ent", "<e2>", ")", "."], "h": {"id": "C0043603", "name": "C0043603#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1868684", "name": "C1868684#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "the", "qualitative", "and", "quantitative", "effects", "of", "C0012177#ent", "<e1>", "biomarkers", "of", "diabetic", "nephropathy", "a", "C0011854#ent", "<e2>", "mouse", "model", "BKS.cg-m", "+", "Lepr(db)/+Lepr(db", ")", "mice", ")", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [21, 22]}}
{"token": ["Glutamate", "modulating", "C0991617#ent", "<e1>", "such", "as", "ketamine", "or", "C0073379#ent", "<e2>", "are", "another", "promising", "approach", "in", "the", "treatment", "of", "depression", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0073379", "name": "C0073379#ent", "pos": [8, 9]}}
{"token": ["A", "selectivity", "of", "C1705431#ent", "<e1>", "(", "CD80", ")", "for", "promoting", "C1423842#ent", "<e2>", "responses", "and", "B7.2", "(", "CD86", ")", "for", "promoting", "Th2", "responses", "in", "the", "murine", "system", "recently", "been", "suggested", "."], "h": {"id": "C1705431", "name": "C1705431#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [10, 11]}}
{"token": ["C0054450#ent", "<e1>", "eluted", "from", "DEAE-cellulose", "in", "the", "same", "fraction", "as", "C1704708#ent", "<e2>"], "h": {"id": "C0054450", "name": "C0054450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "neither", "UVB-", "nor", "TPA-transactivation", "is", "mediated", "through", "C3470429#ent", "<e1>", "Ras", "but", "both", "stimuli", "are", "dependent", "on", "a", "functional", "C0100762#ent", "<e2>"], "h": {"id": "C3470429", "name": "C3470429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0100762", "name": "C0100762#ent", "pos": [20, 21]}}
{"token": ["C0114615#ent", "<e1>", "II", "are", "ATP", "and", "C1417500#ent", "<e2>", "+", "-dependent", "enzymes", "with", "pH", "optima", "of", "7.8", "and", "8.0", "and", "isoelectric", "points", "6.9", "and", "7.6", ",", "respectively", "."], "h": {"id": "C0114615", "name": "C0114615#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [6, 7]}}
{"token": ["The", "angiographic", "appearance", "of", "C4049993#ent", "<e1>", "characteristic", "and", "most", "evident", "in", "the", "C0028961#ent", "<e2>", "and", "anuric", "phases", "."], "h": {"id": "C4049993", "name": "C4049993#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028961", "name": "C0028961#ent", "pos": [12, 13]}}
{"token": ["C0009450#ent", "<e1>", "lead", "to", "C0020305#ent", "<e2>"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [4, 5]}}
{"token": ["These", "results", "demonstrate", "that", "the", "quantitative", "measures", "of", "the", "CATSYS", "system", "can", "document", "significant", "differences", "in", "C0234376#ent", "<e1>", "postural", "sway", "in", "patients", "with", "C1839780#ent", "<e2>", "compared", "to", "controls", "."], "h": {"id": "C0234376", "name": "C0234376#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C1839780", "name": "C1839780#ent", "pos": [23, 24]}}
{"token": ["The", "two", "drugs", "investigated", "were", "C0724709#ent", "<e1>", "(", "a", "sulphonylurea", ")", "and", "phenformin", "(", "a", "C0005382#ent", "<e2>", ")", "."], "h": {"id": "C0724709", "name": "C0724709#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005382", "name": "C0005382#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "our", "data", "suggest", "a", "major", "role", "of", "C3273648#ent", "<e1>", "in", "control", "of", "C1333525#ent", "<e2>", "expression", "in", "intestine", "via", "a", "functional", "HNF-1alpha", "recognition", "element", "C1333525#ent", "<e2>", "promoter", "region", "to", "-165", "."], "h": {"id": "C3273648", "name": "C3273648#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333525", "name": "C1333525#ent", "pos": [14, 15]}}
{"token": ["In", "electromobility", "shift", "supershift", "assays", "we", "show", "the", "presence", "of", "two", "adjacent", "C3273648#ent", "<e1>", "within", "the", "C1333525#ent", "<e2>", "promoter", "regions", "to", "-165", "and", "-169", "to", "-149", "."], "h": {"id": "C3273648", "name": "C3273648#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333525", "name": "C1333525#ent", "pos": [16, 17]}}
{"token": ["These", "observations", "indicate", "a", "significant", "incidence", "of", "mild", "or", "C0271790#ent", "<e1>", "patients", "with", "C0011854#ent", "<e2>", "and", "anti-TMS", "."], "h": {"id": "C0271790", "name": "C0271790#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}}
{"token": ["Thyroid", "autoantibodies", "ThyAb", ")", "and", "C0271790#ent", "<e1>", "more", "frequently", "in", "pregnant", "women", "C0011854#ent", "<e2>", "in", "healthy", "pregnant", "women"], "h": {"id": "C0271790", "name": "C0271790#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [12, 13]}}
{"token": ["These", "results", "demonstrate", "that", "C1824378#ent", "<e1>", "can", "promote", "intestinal", "absorption", "of", "a", "C0030956#ent", "<e2>", "causing", "detrimental", "alterations", "of", "the", "intestinal", "mucosa"], "h": {"id": "C1824378", "name": "C1824378#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["The", "deduced", "amino", "acid", "sequence", "the", "E.", "coli", "C0027203#ent", "<e1>", "is", "60", "%", "C1334043#ent", "<e2>", "with", "the", "sequence", "of", "the", "C0027203#ent", "<e1>", "from", "Bacillus", "stearothermophilus"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["ALE-1", ",", "a", "C1334043#ent", "<e1>", "of", "lysostaphin", ",", "is", "a", "C0027203#ent", "<e2>", "specifically", "lyses", "Staphylococcus", "aureus", "cell", "walls", "cleaving", "the", "pentaglycine", "linkage", "between", "the", "peptidoglycan", "chains"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["Influenza", "viruses", "(", "H1N2", ")", "and", "A/Thailand/271/2005", "(", "H1N1", ")", "were", "isolated", "from", "two", "males", ",", "with", "C0021400#ent", "<e1>", "evidence", "of", "sporadic", "human", "infection", "by", "C2076600#ent", "<e2>"], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C2076600", "name": "C2076600#ent", "pos": [25, 26]}}
{"token": ["HS", "induced", "the", "accumulation", "of", "C3541976#ent", "<e1>", ",", "increased", "the", "interaction", "between", "C3541976#ent", "<e1>", "and", "FAK", ",", "and", "significantly", "inhibited", "FAK", "degradation", "during", "C1705556#ent", "<e1>", "depletion", "."], "h": {"id": "C3541976", "name": "C3541976#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [23, 24]}}
{"token": ["This", "study", "tested", "the", "hypothesis", "that", "C3541976#ent", "<e1>", "interacts", "with", "FAK", ",", "preventing", "caspase-3-mediated", "degradation", "during", "C1705556#ent", "<e2>", "depletion", "."], "h": {"id": "C3541976", "name": "C3541976#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "the", "safety", "and", "efficacy", "of", "2", "dosages", "of", "cevimeline", "for", "the", "treatment", "of", "xerostomia", "and", "C0022575#ent", "<e1>", "patients", "with", "C1527336#ent", "<e2>"], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [21, 22]}}
{"token": ["According", "to", "our", "data", ",", "tear", "mucus", "ferning", "test", "is", "a", "simple", ",", "sensitive", "and", "specific", "test", "to", "estimate", "C0022575#ent", "<e1>", "patients", "with", "C1527336#ent", "<e2>"], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [23, 24]}}
{"token": ["C0068393#ent", "<e1>", "catalyzing", "the", "conversion", "of", "C0064222#ent", "<e2>", "nanaomycin", "A", "which", "is", "the", "first", "step", "in", "the", "biosynthetic", "sequence", "D", "leads", "to", "A", "leads", "to", "E", "leads", "to", "B", ")", "in", "Streptomyces", "rosa", "var"], "h": {"id": "C0068393", "name": "C0068393#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0064222", "name": "C0064222#ent", "pos": [6, 7]}}
{"token": ["Four", "of", "these", "tags", "were", "identified", "as", "fragments", "of", "known", "genes", ",", "encoding", "a", "wool", "keratin", "KRTAP3.2", ",", "a", "desmosome", "component", "desmoglein", "1", "an", "epithelial", "cell", "marker", "C1335813#ent", "<e1>", ",", "and", "a", "C0033640#ent", "<e2>", "Clk3", "."], "h": {"id": "C1335813", "name": "C1335813#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [32, 33]}}
{"token": ["Each", "of", "the", "elements", "is", "bound", "by", "C0812312#ent", "<e1>", ",", "but", "only", "the", "5'HS2", "and", "C1415597#ent", "<e2>", "sites", "are", "bound", "by", "NF-E2", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415597", "name": "C1415597#ent", "pos": [15, 16]}}
{"token": ["This", "C0079429#ent", "<e1>", "has", "therefore", "been", "named", "C1421468#ent", "<e2>", "(", "vaccinia", "virus", "kinase", "related", "kinase", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421468", "name": "C1421468#ent", "pos": [7, 8]}}
{"token": ["The", "virion-derived", "protein", ",", "as", "well", "as", "a", "recombinant", "form", "expressed", "in", "Escherichia", "coli", "exhibited", "C1870389#ent", "<e1>", "and", "dehydroascorbate", "reductase", "activities", "indicative", "of", "a", "functional", "C1415111#ent", "<e2>", "."], "h": {"id": "C1870389", "name": "C1870389#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415111", "name": "C1415111#ent", "pos": [25, 26]}}
{"token": ["C1870389#ent", "<e1>", ",", "like", "the", "analogous", "C14S", "C1415111#ent", "<e2>", "variant", ",", "shows", "weak", "peroxidase", "activity", "."], "h": {"id": "C1870389", "name": "C1870389#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415111", "name": "C1415111#ent", "pos": [7, 8]}}
{"token": ["This", "construct", "was", "found", "to", "be", "directly", "induced", "4-", "to", "5-fold", "by", "co-transfection", "with", "constitutively", "active", "C1454182#ent", "<e1>", "but", "not", "C0031727#ent", "<e2>", "Akt", "."], "h": {"id": "C1454182", "name": "C1454182#ent", "pos": [16, 17]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [20, 21]}}
{"token": ["A", "20-year-old", "woman", "had", "had", "C0014060#ent", "<e1>", "for", "18", "years", "and", "had", "functionally", "significant", "C0264766#ent", "<e2>", "regurgitation", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0264766", "name": "C0264766#ent", "pos": [14, 15]}}
{"token": ["Although", "our", "trial", "has", "limited", "statistical", "power", "we", "find", "that", "in", "PD", "patients", "with", "mild", "acidosis", "Kt/V", "<", "2.1", ",", "C0074722#ent", "<e1>", "improve", "nutritional", "status", "reduce", "the", "C0720099#ent", "<e2>", "of", "hospitalization", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [27, 28]}}
{"token": ["The", "endogenous", "retroviral", "envelope", "glycoprotein", "C1539357#ent", "<e1>", ",", "implicated", "in", "murine", "C0024143#ent", "<e2>", "secreted", "by", "hepatocytes", "as", "an", "acute", "phase", "protein", "and", "it", "has", "been", "thought", "to", "be", "a", "product", "of", "an", "endogenous", "xenotropic", "virus", "NZB-X1", "."], "h": {"id": "C1539357", "name": "C1539357#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [11, 12]}}
{"token": ["Kaolin", "pleurisy", "3", "h", "was", "suppressed", "by", "C0021246#ent", "<e1>", ",", "mefenamic", "acid", "paramethasone", ",", "bromelain", "and", "soy-bean", "trypsin", "inhibitor", "while", "C0032231#ent", "<e2>", "3", "h", "was", "suppressed", "significantly", "by", "C0021246#ent", "<e1>", "and", "paramethasone", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032231", "name": "C0032231#ent", "pos": [20, 21]}}
{"token": ["C0235025#ent", "<e1>", "associated", "with", "cryoglobulinemia", "and", "a", "systemic", "vasculitis", "a", "well-described", "complication", "of", "C4288963#ent", "<e2>"], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4288963", "name": "C4288963#ent", "pos": [13, 14]}}
{"token": ["Cryoglobulinemia", "represents", "an", "emerging", "cause", "of", "C0235025#ent", "<e1>", "especially", "in", "Southern", "Europe", "in", "view", "of", "its", "relationship", "with", "C4288963#ent", "<e2>"], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4288963", "name": "C4288963#ent", "pos": [18, 19]}}
{"token": ["These", "results", "suggest", "that", "C1704820#ent", "<e1>", "acts", "as", "a", "positive", "regulator", "of", "C1704708#ent", "<e2>", "and", "as", "a", "new", "target", "of", "rapamycin", "in", "the", "activation", "of", "lymphocytes", "."], "h": {"id": "C1704820", "name": "C1704820#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [12, 13]}}
{"token": ["MID1", "is", "a", "microtubule-associated", "protein", "stabilizes", "microtubules", "and", ",", "in", "association", "with", "the", "regulatory", "subunit", "protein", "phosphatase", "2A", "C1704708#ent", "<e1>", ")", ",", "C1704820#ent", "<e2>", ",", "provides", "ubiquitin", "ligase", "activity", "the", "ubiquitin-specific", "modification", "C1704708#ent", "<e1>", "."], "h": {"id": "C1704820", "name": "C1704820#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [18, 19]}}
{"token": ["We", "here", "demonstrate", "that", "a", "murine", "C1522428#ent", "<e1>", "J774.1", "cells", "expressed", "C3715112#ent", "<e2>", "mRNA", "and", "reductase", "activity", "both", "of", "which", "were", "augmented", "by", "lipopolysaccharide", "(LPS)-induced", "cell", "activation"], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3715112", "name": "C3715112#ent", "pos": [11, 12]}}
{"token": ["Inhibitors", "of", "C1333891#ent", "<e1>", "HDACs", ")", "activate", "the", "sodium", "iodide", "symporter", "C1420204#ent", "<e2>", ")", "expression", "in", "thyroid", "tumor", "cells"], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420204", "name": "C1420204#ent", "pos": [11, 12]}}
{"token": ["Confocal", "images", "of", "fish", "neutrophil", "suspensions", "stained", "with", "6'-diamino-2-phenylindole", ",", "dihydrochloride", "DNA", "fluorescent", "stain", "(", "C0057142#ent", "<e1>", ")", "revealed", "the", "presence", "of", "C1423506#ent", "<e2>", "which", "appeared", "as", "fibrous", "structures", "several", "cells", "."], "h": {"id": "C0057142", "name": "C0057142#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1423506", "name": "C1423506#ent", "pos": [22, 23]}}
{"token": ["To", "prepare", "monoclonal", "antibodies", "MAbs", ")", "directed", "against", "the", "core-lipid", "A", "fractions", "of", "smooth", "lipopoly-saccharide", "(", "LPS", ")", "from", "C0519030#ent", "<e1>", ",", "we", "immunized", "BALB/c", "mice", "the", "C3273508#ent", "<e2>", "LPS", "."], "h": {"id": "C0519030", "name": "C0519030#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3273508", "name": "C3273508#ent", "pos": [27, 28]}}
{"token": ["We", "isolated", "C3539609#ent", "<e1>", "(", "protein", "inhibitor", "activated", "STAT1", ")", "as", "a", "C1539895#ent", "<e2>", "binding", "protein", "yeast", "two-hybrid", "screening", "."], "h": {"id": "C3539609", "name": "C3539609#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539895", "name": "C1539895#ent", "pos": [12, 13]}}
{"token": ["The", "natural", "killer", "NK", ")", "cell", "immunoglobulin-like", "receptors", "KIRs", ")", "and", "leukocyte", "immunoglobulin-like", "receptor", "LILR", ",", "also", "known", "as", "ILT", "and", "C1540295#ent", "<e1>", ")", "gene", "clusters", "within", "this", "region", "in", "the", "C3831172#ent", "<e2>", "LRC", ")", "."], "h": {"id": "C1540295", "name": "C1540295#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3831172", "name": "C3831172#ent", "pos": [31, 32]}}
{"token": ["C0887942#ent", "<e1>", "concentrations", "in", "the", "plasma", "of", "patients", "with", "sepsis", "and", "C0025297#ent", "<e2>", "correlated", "only", "weakly", "(", "r", "=", "0.38", ")", "with", "blood", "neutrophil", "count"], "h": {"id": "C0887942", "name": "C0887942#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [11, 12]}}
{"token": ["Pure", "C0015468#ent", "<e1>", "most", "often", "due", "to", "C0037199#ent", "<e2>", "and", "the", "chewing", "apparatus", "but", "also", "a", "multitude", "of", "other", "causes", "."], "h": {"id": "C0015468", "name": "C0015468#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [7, 8]}}
{"token": ["Very", "few", "neutrophils", "were", "found", "in", "spontaneously", "occurring", "C0037284#ent", "<e1>", "with", "an", "induced", "C0032342#ent", "<e2>"], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032342", "name": "C0032342#ent", "pos": [13, 14]}}
{"token": ["We", "have", "measured", "the", "plasma", "levels", "of", "salbutamol", ",", "terbutaline", "and", "theophylline", "in", "140", "patients", "(", "70", "men", ",", "mean", "age", "57", "C1710700#ent", "<e1>", ")", "arriving", "for", "emergency", "treatment", "severe", "C0004096#ent", "<e2>"], "h": {"id": "C1710700", "name": "C1710700#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [30, 31]}}
{"token": ["To", "characterize", "annual", "variability", "in", "airways", "responsiveness", "we", "administered", "a", "high-dose", "methacholine", "challenge", "at", "1", "yr", "intervals", "for", "up", "to", "4", "C1710700#ent", "<e1>", "to", "105", "healthy", ",", "C0004096#ent", "<e2>", "working", "subjects", "."], "h": {"id": "C1710700", "name": "C1710700#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [27, 28]}}
{"token": ["The", "acutely", "ill", "perennial", "asthmatics", "(", "n=22", ",", "mean", "age=39.4", "C1710700#ent", "<e1>", ")", "were", "included", "on", "the", "basis", "of", "hospitalization", "for", "C0004096#ent", "<e2>"], "h": {"id": "C1710700", "name": "C1710700#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}}
{"token": ["At", "potentials", "between", "-40", "and", "-10", "mV", ",", "the", "waveform", "of", "the", "C0271829#ent", "<e1>", "consisted", "of", "a", "C0027867#ent", "<e2>", "component", "enveloped", "by", "a", "hyperpolarizing", "component", "."], "h": {"id": "C0271829", "name": "C0271829#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "the", "non-NMDA", "receptor", "blocker", "CNQX", "demonstrated", "potent", "anticonvulsant", "property", "by", "reducing", "the", "C0271829#ent", "<e1>", "into", "a", "C0027867#ent", "<e2>", "potential", "that", "was", "graded", "in", "nature", "."], "h": {"id": "C0271829", "name": "C0271829#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [19, 20]}}
{"token": ["C0146953#ent", "<e1>", "extracts", "of", "isolated", "C0268731#ent", "<e2>", "were", "subjected", "to", "phase", "separation", "and", "the", "resultant", "detergent", "and", "aqueous", "phases", "were", "used", "to", "immunize", "mice", "."], "h": {"id": "C0146953", "name": "C0146953#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [5, 6]}}
{"token": ["Epidermoid", "cysts", "expressed", "C1416714#ent", "<e1>", "and", "eruptive", "vellus", "hair", "cysts", "expressed", "C1416728#ent", "<e2>", ",", "whereas", "trichilemmal", "cysts", "steatocystoma", "multiplex", "expression", "of", "both", "C1416714#ent", "<e1>", "and", "C1416728#ent", "<e2>", "."], "h": {"id": "C1416728", "name": "C1416728#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416714", "name": "C1416714#ent", "pos": [3, 4]}}
{"token": ["The", "inner", "layers", "some", "keratinous", "cysts", "expressed", "CK6", ",", "CK10/11", "and", "C1416728#ent", "<e1>", ",", "but", "only", "C1416714#ent", "<e2>", "in", "others", "."], "h": {"id": "C1416728", "name": "C1416728#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416714", "name": "C1416714#ent", "pos": [16, 17]}}
{"token": ["Adverse", "reactions", "C0031436#ent", "<e1>", ",", "including", "hypotension", ",", "sedation", ",", "drowsiness", ",", "extrapyramidal", "symptoms", "C0686347#ent", "<e2>", "cardiac", "toxicity", "agranulocytosis", ",", "are", "often", "more", "common", "and", "severe", "than", "those", "attributed", "to", "narcotic", "analgesics"], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0686347", "name": "C0686347#ent", "pos": [14, 15]}}
{"token": ["Sequence", "analyses", "six", "unique", "lineages", "of", "avian", "malaria", ",", "three", "Plasmodium", "(", "LK5", ",", "C1412807#ent", "<e1>", ",", "RTSR1", ")", "and", "three", "Haemoproteus", "(", "C1332012#ent", "<e2>", ",", "LK3", ",", "LK4", ")", "."], "h": {"id": "C1412807", "name": "C1412807#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332012", "name": "C1332012#ent", "pos": [23, 24]}}
{"token": ["Results", "have", "been", "generally", "disappointing", "but", "in", "vitro", "animal", "data", "an", "important", "role", "for", "C0054173#ent", "<e1>", "in", "combination", "with", "C0304497#ent", "<e2>"], "h": {"id": "C0054173", "name": "C0054173#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0304497", "name": "C0304497#ent", "pos": [19, 20]}}
{"token": ["He", "also", "had", "C0018418#ent", "<e1>", "and", "was", "diagnosed", "as", "having", "C1366496#ent", "<e2>", "excess", "syndrome", "."], "h": {"id": "C0018418", "name": "C0018418#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1366496", "name": "C1366496#ent", "pos": [10, 11]}}
{"token": ["Only", "one", "of", "the", "C0086376#ent", "<e1>", "encoded", "by", "the", "virus", ",", "here", "referred", "to", "as", "C2987017#ent", "<e2>", "Rep", "protein", ",", "is", "indispensable", "for", "replication", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987017", "name": "C2987017#ent", "pos": [15, 16]}}
{"token": ["In", "this", "article", "we", "will", "present", "an", "overview", "of", "C0029896#ent", "<e1>", "caused", "by", "mutations", "in", "the", "C3811802#ent", "<e2>", "review", "the", "known", "pathogenic", "p63", "gene", "mutations"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811802", "name": "C3811802#ent", "pos": [16, 17]}}
{"token": ["Among", "the", "natural", "serine", "protease", "inhibitors", "tested", ",", "Bowman-Birk", "soybean", "protease", "inhibitor", "Eglin", "C", "and", "human", "alpha", "1-antichymotrypsin", "inhibited", "C4084825#ent", "<e1>", "more", "strongly", "than", "did", "C0035100#ent", "<e2>", ",", "Kunitz", "soybean", "protease", "inhibitor", "and", "phosphatidylserine", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0035100", "name": "C0035100#ent", "pos": [25, 26]}}
{"token": ["To", "study", "the", "significance", "of", "local", "production", "Ang", "II", "C4084825#ent", "<e1>", ",", "we", "examined", "the", "effects", "of", "C0035100#ent", "<e2>", "on", "in", "vivo", "angiogenesis", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035100", "name": "C0035100#ent", "pos": [17, 18]}}
{"token": ["C0033634#ent", "<e1>", "disrupts", "the", "stimulatory", "effect", "of", "C1420236#ent", "<e2>", "on", "CFTR", "channel", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420236", "name": "C1420236#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "clorgyline", ",", "a", "selective", "inhibitor", "of", "C3657721#ent", "<e1>", "and", "pargyline", ",", "an", "inhibitor", "of", "both", "C1417001#ent", "<e2>", "B", ",", "both", "did", "not", "have", "an", "effect", "on", "L-DOPA", "toxicity", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417001", "name": "C1417001#ent", "pos": [17, 18]}}
{"token": ["A", "patient", "with", "C3494506#ent", "<e1>", "found", "to", "have", "C0020676#ent", "<e2>"], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [8, 9]}}
{"token": ["We", "also", "compared", "serum", "MDA", "levels", "in", "two", "major", "groups", "of", "patients", "with", "C0948008#ent", "<e1>", "from", "small", "vessel", "large", "C3275121#ent", "<e2>", "respectively", "."], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [19, 20]}}
{"token": ["Salicylate", "hydroxylase", "Pseudomonas", "putida", "EC", "1.14.13.1", "C0036077#ent", "<e1>", ",", "NADH", ":", "oxygen", "oxidoreductase", "is", "an", "C1414645#ent", "<e2>", "which", "catalyzes", "decarboxylative", "hydroxylation", "C0036077#ent", "<e1>", "to", "produce", "catechol", "in", "the", "presence", "of", "NADH", "and", "O2", "."], "h": {"id": "C1414645", "name": "C1414645#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [6, 7]}}
{"token": ["Anesthesia", "was", "maintained", "with", "continuous", "epidural", "administration", "C0887621#ent", "<e1>", ",", "inhalation", "of", "sevoflurane", "and", "nitrous", "oxide", "oxygen", "and", "C0042435#ent", "<e2>"], "h": {"id": "C0887621", "name": "C0887621#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [18, 19]}}
{"token": ["The", "main", "clinical", "findings", "of", "the", "benign-type", "of", "osteopetrosis", "(", "C2936739#ent", "<e1>", "are", "fractures", "and", "C0029443#ent", "<e2>", "of", "the", "mandible", ",", "leading", "to", "the", "detection", "of", "the", "disease", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [15, 16]}}
{"token": ["This", "genetic", "resistance", "on", "complementation", "of", "B-linked", "genes", "complementation", "of", "C1417679#ent", "<e1>", "outside", "the", "C1588750#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1588750", "name": "C1588750#ent", "pos": [14, 15]}}
{"token": ["A", "few", "strong", "reactions", "of", "MLC", "between", "B", "identical", "individuals", "indicated", ",", "however", ",", "that", "chickens", "in", "addition", "may", "have", "Lads", "controlled", "C1417679#ent", "<e1>", "not", "closely", "linked", "to", "the", "C1588750#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1588750", "name": "C1588750#ent", "pos": [29, 30]}}
{"token": ["Nor", "were", "Lads", "encoded", "by", "C1417679#ent", "<e1>", "unlinked", "to", "the", "C1588750#ent", "<e2>", "for", "these", "reactions", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1588750", "name": "C1588750#ent", "pos": [10, 11]}}
{"token": ["Intracellular", "C2698835#ent", "<e1>", ")", "is", "composed", "of", "a", "regulatory", "subunit", "C1418245#ent", "<e2>", ",", "and", "two", "highly", "conserved", "but", "non-identical", "catalytic", "subunits", "Pafah1b2", "and", "Pafah1b3", "."], "h": {"id": "C2698835", "name": "C2698835#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418245", "name": "C1418245#ent", "pos": [10, 11]}}
{"token": ["We", "concluded", "that", "intravenous", "tenoxicam", "has", "rapid", "and", "prolong", "analgesic", "effects", "the", "treatment", "of", "acute", "biliary", "colic", "compared", "to", "C0036442#ent", "<e1>", "N-butylbroimde", "and", "it", "prevents", "the", "progression", "to", "C0008325#ent", "<e2>"], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0008325", "name": "C0008325#ent", "pos": [28, 29]}}
{"token": ["Reductions", "in", "activity", "of", "C1420627#ent", "<e1>", ",", "the", "major", "C0597298#ent", "<e2>", "of", "starch", "synthase", "for", "amylopectin", "synthesis", "in", "the", "potato", "tuber", "result", "in", "fissuring", "of", "the", "starch", "granules", "."], "h": {"id": "C1420627", "name": "C1420627#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [9, 10]}}
{"token": ["Premutation", "alleles", "(", "55", "-", "200", "CGG", "repeats", "of", "the", "fragile", "X", "mental", "retardation", "1", "FMR1", ")", "gene", "are", "associated", "with", "autism", "spectrum", "disorder", "childhood", ",", "C0085215#ent", "<e1>", "and", "the", "neurodegenerative", "disorder", "fragile", "X-associated", "tremor/ataxia", "syndrome", "C1839780#ent", "<e2>", ")", "."], "h": {"id": "C0085215", "name": "C0085215#ent", "pos": [26, 27]}, "relation": "manifestation_of", "t": {"id": "C1839780", "name": "C1839780#ent", "pos": [36, 37]}}
{"token": ["Premutation", "alleles", "(", "55", "-", "200", "CGG", "repeats", "of", "the", "fragile", "X", "mental", "retardation", "1", "FMR1", ")", "gene", "are", "associated", "with", "autism", "spectrum", "disorder", "childhood", ",", "C0085215#ent", "<e1>", "and", "the", "neurodegenerative", "disorder", "C1839780#ent", "<e2>", "FXTAS", ")", "."], "h": {"id": "C0085215", "name": "C0085215#ent", "pos": [26, 27]}, "relation": "manifestation_of", "t": {"id": "C1839780", "name": "C1839780#ent", "pos": [32, 33]}}
{"token": ["Thus", ",", "C0380393#ent", "<e1>", "may", "possess", "anxiolytic", "effects", "addition", "to", "its", "C0040615#ent", "<e2>", "properties", "."], "h": {"id": "C0380393", "name": "C0380393#ent", "pos": [2, 3]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [11, 12]}}
{"token": ["Given", "the", "preliminary", "results", ",", "double-blind", ",", "placebo-controlled", "trials", "quetiapine", "and", "C0380393#ent", "<e1>", "are", "needed", ",", "as", "well", "as", "studies", "comparing", "atypical", "C0040615#ent", "<e2>", "traditional", "augmentation", "agents", "the", "treatment", "of", "depression", "."], "h": {"id": "C0380393", "name": "C0380393#ent", "pos": [11, 12]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [22, 23]}}
{"token": ["Chlorpromazine", ",", "haloperidol", ",", "fluphenazine", ",", "clozapine", ",", "risperidone", ",", "quetiapine", ",", "olanzapine", ",", "C0380393#ent", "<e1>", ",", "and", "aripiprazole", "are", "C0040615#ent", "<e2>", "commonly", "used", "in", "psychiatric", "medicine"], "h": {"id": "C0380393", "name": "C0380393#ent", "pos": [14, 15]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [20, 21]}}
{"token": ["Since", "C4082991#ent", "<e1>", "is", "an", "C1334289#ent", "<e2>", "and", "mPGES-2h", "is", "a", "lyase", ",", "C4082991#ent", "<e1>", "can", "not", "simply", "be", "classified", "into", "one", "of", "six", "classes", "set", "by", "the", "International", "Union", "of", "Biochemistry", "Molecular", "Biology"], "h": {"id": "C4082991", "name": "C4082991#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334289", "name": "C1334289#ent", "pos": [5, 6]}}
{"token": ["Compound", "C", "significantly", "increased", "palmitate", "oxidation", "in", "the", "presence", "of", "inhibitory", "concentrations", "of", "malonyl-CoA", "and", "C0059872#ent", "<e1>", "indicating", "an", "increase", "in", "C1413688#ent", "<e2>", "activity", "."], "h": {"id": "C0059872", "name": "C0059872#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1413688", "name": "C1413688#ent", "pos": [21, 22]}}
{"token": ["It", "was", "the", "purpose", "of", "the", "present", "study", "to", "determine", "whether", "C0069751#ent", "<e1>", "might", "be", "suitable", "for", "the", "treatment", "of", "canine", "C0014547#ent", "<e2>", "."], "h": {"id": "C0069751", "name": "C0069751#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [21, 22]}}
{"token": ["Since", "C1705340#ent", "<e1>", "inhibits", "platelet", "aggregation", "in", "vitro", ",", "the", "possibility", "that", "hyperparathyroidism", "of", "C0041948#ent", "<e2>", "plays", "a", "role", "in", "the", "pathogenesis", "of", "uraemic", "bleeding", "has", "been", "considered", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [14, 15]}}
{"token": ["It", "is", "concluded", "that", "elevated", "C1705340#ent", "<e1>", "values", "in", "renal-failure", "patients", "do", "not", "contribute", "to", "C0041948#ent", "<e2>", "platelet", "defect", "as", "reflected", "by", "the", "skin", "bleeding", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [15, 16]}}
{"token": ["Parathormone", "(", "C1705340#ent", "<e1>", ")", "is", "a", "very", "potent", "C0041948#ent", "<e2>", "toxin", ",", "which", "affects", "heart", "structure", "function", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [9, 10]}}
{"token": ["Noteworthily", ",", "C0031404#ent", "<e1>", "always", "coexisted", "with", "the", "C1333524#ent", "<e2>", "FABP", ")", ",", "which", "participates", "in", "the", "uptake", "and", "metabolic", "processing", "of", "long", "chain", "fatty", "acids"], "h": {"id": "C0031404", "name": "C0031404#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333524", "name": "C1333524#ent", "pos": [8, 9]}}
{"token": ["Cholesterol", "lowering", "by", "C0218596#ent", "<e1>", "and", "cholestyramine", "was", "additive", ",", "and", "the", "increase", "in", "C0020374#ent", "<e2>", "about", "by", "cholestyramine", "was", "attenuated", "significantly", "by", "C0218596#ent", "<e1>", "."], "h": {"id": "C0218596", "name": "C0218596#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [14, 15]}}
{"token": ["Spitz", "nevi", "show", "no", "BRAF", "mutations", ",", "while", "a", "subset", "of", "cases", "show", "C1616867#ent", "<e1>", "mutations", ",", "often", "associated", "with", "copy", "number", "of", "C0812435#ent", "<e2>"], "h": {"id": "C1616867", "name": "C1616867#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812435", "name": "C0812435#ent", "pos": [23, 24]}}
{"token": ["At", "the", "same", "time", "mean", "C3642267#ent", "<e1>", "in", "the", "other", "lower", "C1428707#ent", "<e2>", "was", "0.48", "."], "h": {"id": "C3642267", "name": "C3642267#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1428707", "name": "C1428707#ent", "pos": [11, 12]}}
{"token": ["However", ",", "the", "C0887847#ent", "<e1>", "predominantly", "labeled", "in", "C5b-8", "and", "both", "C8", "alpha", "C3540507#ent", "<e2>", "were", "predominantly", "labeled", "in", "C5b-9", "."], "h": {"id": "C0887847", "name": "C0887847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540507", "name": "C3540507#ent", "pos": [13, 14]}}
{"token": ["Inhibition", "of", "activin", "receptor-like", "kinase", "C1704943#ent", "<e1>", ")", "5", "blocks", "these", "effects", ",", "whereas", "C0907533#ent", "<e2>", "active", "(", "ca", ")", "ALK5", "increases", "cell", "invasion", "42", "%", "."], "h": {"id": "C1704943", "name": "C1704943#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}}
{"token": ["As", "a", "consequence", "of", "chromosomal", "translocations", "the", "alk", "gene", "2p23", ")", ",", "C1704943#ent", "<e1>", "is", "also", "aberrantly", "expressed", "and", "C0907533#ent", "<e2>", "activated", "in", "approximately", "60", "%", "of", "CD30+", "anaplastic", "large", "cell", "lymphomas", "ALCLs", ")", "."], "h": {"id": "C1704943", "name": "C1704943#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [19, 20]}}
{"token": ["The", "release", "of", "FFA", "can", "be", "inhibited", "partly", "by", "C0007681#ent", "<e1>", "N6-cyclopentyladenosine", ",", "pentobarbital", ",", "ethanol", ",", "or", "4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3(2H)-one", "(", "C0047845#ent", "<e2>", ")", "."], "h": {"id": "C0007681", "name": "C0007681#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0047845", "name": "C0047845#ent", "pos": [20, 21]}}
{"token": ["It", "is", "probable", "that", ",", "together", "with", "a", "pathologic", "process", "induced", "by", "C0020550#ent", "<e1>", ",", "the", "autonomic", "nervous", "system", "in", "our", "patient's", "episodic", "C0795996#ent", "<e2>", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0795996", "name": "C0795996#ent", "pos": [23, 24]}}
{"token": ["This", "stimulation", "was", "also", "observed", "when", "a", "higher", "level", "of", "20-hydroxyecdysone", "was", "maintained", ",", "and", "prevented", "by", "C0033607#ent", "<e1>", "indicating", "that", "20-hydroxyecdysone", "does", "not", "act", "directly", "on", "this", "C0017337#ent", "<e2>", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [28, 29]}}
{"token": ["These", "results", "suggested", "that", "a", "potential", "compound", "to", "treat", "C0020456#ent", "<e1>", ",", "hyperlipidemia", ",", "and", "C2936179#ent", "<e2>", "be", "developed", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2936179", "name": "C2936179#ent", "pos": [15, 16]}}
{"token": ["In", "hepatic", "macrophages", "Northern", "blot", "cloned", "IL-10R", "cDNA", "detected", "an", "expected", "3.5-kb", "transcript", ",", "and", "IL-10R", "and", "C1413710#ent", "<e1>", "-", "4", "mRNAs", "showed", "steady", "C0669365#ent", "<e2>", "expression", "after", "in", "vitro", "lipopolysaccharide", "treatment", "or", "cholestatic", "liver", "injury"], "h": {"id": "C1413710", "name": "C1413710#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}}
{"token": ["However", ",", "under", "some", "experimental", "conditions", "C0034282#ent", "<e1>", "appeared", "to", "antagonize", "the", "modulatory", "effects", "the", "adenosine", "A(3)", "receptor", "C2987634#ent", "<e2>", "on", "cytokine", "responses"], "h": {"id": "C0034282", "name": "C0034282#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [18, 19]}}
{"token": ["C0034282#ent", "<e1>", ",", "atropine", "and", "propranolol", "competitively", "antagonized", "their", "respective", "C2987634#ent", "<e2>", "(", "i.e.", "histamine", ",", "carbachol", "and", "isoproterenol", ")", "confirming", "the", "presence", "of", "H1-histaminergic", ",", "muscarinic-cholinergic", "and", "beta-adrenergic", "receptors", "."], "h": {"id": "C0034282", "name": "C0034282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}}
{"token": ["The", "C1416899#ent", "<e1>", "a", "48", "%", "identity", "with", "both", "lysyl", "oxidase", "C3272401#ent", "<e2>", "a", "region", "corresponding", "to", "exons", "2", "6", ",", "implying", "the", "existence", "of", "a", "lysyl", "oxidase", "gene", "family"], "h": {"id": "C1416899", "name": "C1416899#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3272401", "name": "C3272401#ent", "pos": [11, 12]}}
{"token": ["The", "possible", "involvement", "of", "C0010531#ent", "<e1>", "PKA", ")", "in", "the", "C0026815#ent", "<e2>", "inhibition", "of", "the", "slow", "afterhyperpolarizing", "current", "(", "IAHP", ")", "was", "investigated", "in", "rat", "hippocampal", "pyramidal", "cells"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026815", "name": "C0026815#ent", "pos": [10, 11]}}
{"token": ["Both", "a", "C0031669#ent", "<e1>", "2-nitro-4-carboxyphenyl-n", ",", "n-diphenylcarbamate", "(", "NCDC", ")", ",", "and", "a", "C1334539#ent", "<e2>", "1-(5-chloronaphthalenesulfonyl)-1H-hexahydro-1,4-diazepine", "(", "ML-9", ")", ",", "suppressed", "this", "augmented", "response", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [13, 14]}}
{"token": ["Liver", "involvement", "in", "C0002895#ent", "<e1>", "take", "place", "due", "to", "the", "C0242634#ent", "<e2>", "or", "to", "secondary", "conditions", "as", "iron", "overload", "viral", "hepatitis", "cholelithiasis", "."], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242634", "name": "C0242634#ent", "pos": [10, 11]}}
{"token": ["A", "significant", "downregulation", "in", "the", "colon", "was", "obtained", "for", "C1417494#ent", "<e1>", "in", "C1705969#ent", "<e2>", "and", "MUC12", "in", "C1705969#ent", "<e2>", "and", "UC", "."], "h": {"id": "C1417494", "name": "C1417494#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [12, 13]}}
{"token": ["Blockade", "of", "mRNA", "synthesis", "protein", "kinase", "C", "activation", "or", "C0060916#ent", "<e1>", "prevented", "enhanced", "phagocytosis", "by", "either", "C1333196#ent", "<e2>", "."], "h": {"id": "C0060916", "name": "C0060916#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [16, 17]}}
{"token": ["By", "RT-PCR", ",", "we", "confirmed", "the", "findings", "for", "one", "upregulated", "sequence", "(", "Rad", ",", "a", "C0060916#ent", "<e1>", "and", "one", "downregulated", "sequence", "(", "osteopontin", ",", "a", "C1333196#ent", "<e2>", ")", "."], "h": {"id": "C0060916", "name": "C0060916#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [25, 26]}}
{"token": ["A", "minor", "fraction", "of", "serum", "C1426033#ent", "<e1>", "is", "not", "associated", "with", "C3653288#ent", "<e2>"], "h": {"id": "C1426033", "name": "C1426033#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3653288", "name": "C3653288#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "directly", "if", "this", "assignment", "was", "correct", "and", "if", "these", "two", "C3539946#ent", "<e1>", "the", "only", "nucleophiles", "required", "for", "C1704793#ent", "<e2>", "enzyme", "activity"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [25, 26]}}
{"token": ["The", "C3539946#ent", "<e1>", "derivatized", "with", "the", "chiral", "reagent", "chloroformate", "(", "C1704793#ent", "<e2>", ")", "and", "separated", "using", "a", "mixed", "micellar", "separation", "system", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [10, 11]}}
{"token": ["During", "the", "last", "10", "years", ",", "an", "increasing", "number", "of", "C0017337#ent", "<e1>", "have", "been", "identified", "whose", "abnormalities", "account", "for", "C0398686#ent", "<e2>", "with", "defects", "in", "development", "and/or", "function", "of", "the", "immune", "system"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0398686", "name": "C0398686#ent", "pos": [19, 20]}}
{"token": ["Serum", "levels", "VEGF", "and", "bFGF", "in", "RAEB", "patients", "and", "RAEBT", "patients", "were", "higher", "than", "that", "in", "C0003873#ent", "<e1>", "patients", "and", "C0034678#ent", "<e2>", "patients", "(", "P", "<", "0.05", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [20, 21]}}
{"token": ["C0268272#ent", "<e1>", "a", "rare", "C0019247#ent", "<e2>", "by", "lack", "of", "lysosomal", "beta-galactosidase", "characterized", "by", "a", "slowly", "progressive", "course", ",", "and", "extrapyramidal", "signs", "but", "without", "prominent", "skeletal", "changes", "or", "visceromegaly", "."], "h": {"id": "C0268272", "name": "C0268272#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [4, 5]}}
{"token": ["Possible", "mechanisms", "for", "C1417487#ent", "<e1>", "binding", "to", "S.", "maltophilia", "C0039667#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "they", "suggest", "that", "some", "unmetabolized", "C1417487#ent", "<e1>", "was", "retained", "in", "cells", "not", "bound", "to", "C0039667#ent", "<e2>", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [17, 18]}}
{"token": ["Mutations", "in", "C1426244#ent", "<e1>", "are", "responsible", "for", "C0272170#ent", "<e2>", "SDS", ")", ",", "a", "disorder", "with", "clinical", "features", "of", "exocrine", "pancreatic", "insufficiency", "bone", "marrow", "failure", "and", "skeletal", "abnormalities"], "h": {"id": "C1426244", "name": "C1426244#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [7, 8]}}
{"token": ["We", "conclude", "that", "nitroglycerin", "ointment", "applied", "to", "the", "back", "of", "the", "hand", "before", "injection", "reduces", "the", "incidence", "of", "C0030193#ent", "<e1>", "injection", "with", "C0033487#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [22, 23]}}
{"token": ["Similar", "sequences", "were", "identified", "in", "natural", "protein", "substrates", "such", "as", "NFkappaB", "and", "C3470429#ent", "<e1>", "that", "are", "specifically", "cleaved", "by", "C1335267#ent", "<e2>", "."], "h": {"id": "C3470429", "name": "C3470429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335267", "name": "C1335267#ent", "pos": [19, 20]}}
{"token": ["Pretreatment", "of", "skin", "with", "all-trans", "retinoic", "acid", "C0524890#ent", "<e1>", ")", "inhibits", "UV", "induction", "of", "C0127082#ent", "<e2>"], "h": {"id": "C0524890", "name": "C0524890#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [14, 15]}}
{"token": ["Effects", "of", "flavourings", "such", "as", "C0078032#ent", "<e1>", ",", "ethylvanillin", ",", "anisaldehyde", ",", "cinnamaldehyde", ",", "C0010206#ent", "<e2>", "and", "umbelliferone", "on", "the", "induction", "of", "SCEs", "by", "MMC", "were", "investigated", "in", "cultured", "Chinese", "hamster", "ovary", "cells"], "h": {"id": "C0078032", "name": "C0078032#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010206", "name": "C0010206#ent", "pos": [14, 15]}}
{"token": ["The", "beneficial", "effects", "of", "C1704897#ent", "<e1>", "treatment", "for", "intractable", "C0340288#ent", "<e2>", "reduction", "in", "pain", "and", "improvement", "in", "QOL", "."], "h": {"id": "C1704897", "name": "C1704897#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "investigate", "effects", "of", "pretreatment", "of", "C0035457#ent", "<e1>", "AR", ")", "with", "C0700480#ent", "<e2>", ",", "and", "montelukast", ",", "alone", "and", "in", "combination", "."], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0700480", "name": "C0700480#ent", "pos": [17, 18]}}
{"token": ["In", "a", "double-blind", "clinical", "trial", ",", "oral", "fexofenadine", "120", "or", "180", "mg", "once", "daily", "controlled", "symptoms", "patients", "with", "C0035457#ent", "<e1>", "effectively", "as", "C0700480#ent", "<e2>", "."], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0700480", "name": "C0700480#ent", "pos": [22, 23]}}
{"token": ["Fifty-three", "C1171558#ent", "<e1>", "complexes", "were", "tested", ",", "including", "a", "number", "of", "C0031957#ent", "<e2>", "synthesized", "for", "this", "work", "."], "h": {"id": "C1171558", "name": "C1171558#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [11, 12]}}
{"token": ["We", "report", "for", "the", "first", "time", "monozygous", "twins", "with", "a", "microdeletion", "syndrome", "genes", "coding", "for", "C0218158#ent", "<e1>", "Btk", ")", "and", "C0796074#ent", "<e2>", "DDP1", ")", ",", "and", "two", "other", "genes", "."], "h": {"id": "C0218158", "name": "C0218158#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [20, 21]}}
{"token": ["The", "inhibitory", "effects", "of", "cimetidine", ",", "C0085154#ent", "<e1>", "and", "omeprazole", "on", "the", "metabolic", "activity", "C0608437#ent", "<e2>", ",", "2C19", ",", "2D6", "and", "3A", "were", "investigated", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0085154", "name": "C0085154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [14, 15]}}
{"token": ["Several", "C1417679#ent", "<e1>", "regulated", "by", "C0245514#ent", "<e2>", ",", "one", "of", "the", "most", "potent", "thiazolidinediones", ",", "in", "matured", "3T3-L1", "adipocytes-were", "obtained", "by", "differential", "display", "method", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0245514", "name": "C0245514#ent", "pos": [5, 6]}}
{"token": ["Soon", ",", "C0524620#ent", "<e1>", "overtake", "cigarette", "smoking", "the", "number", "one", "risk", "factor", "C0018799#ent", "<e2>", "the", "US", "population", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [12, 13]}}
{"token": ["The", "tyrosine", "phosphorylation", "C0909826#ent", "<e1>", "attenuates", "association", "of", "C0909826#ent", "<e1>", "with", "C3889408#ent", "<e1>", ",", "decreasing", "integration", "of", "C0909826#ent", "<e1>", "into", "sites", "of", "cell-cell", "contact", "and", "enhancing", "paracellular", "permeability"], "h": {"id": "C3889408", "name": "C3889408#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0909826", "name": "C0909826#ent", "pos": [3, 4]}}
{"token": ["C0022658#ent", "<e1>", "when", "it", "occurred", ",", "more", "closely", "resembled", "pregnancy-induced", "hypertension", "C0024143#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [11, 12]}}
{"token": ["Rectal", "(", "Tre", ")", "and", "mean", "skin", "C1823517#ent", "<e1>", ")", "temperatures", ",", "metabolic", "heat", "production", "M", ")", ",", "systolic", "(", "C1849718#ent", "<e2>", ")", "and", "diastolic", "(", "BPd", ")", "blood", "pressures", "heart", "rate", "fc", ")", "were", "measured", "."], "h": {"id": "C1823517", "name": "C1823517#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1849718", "name": "C1849718#ent", "pos": [20, 21]}}
{"token": ["Some", "of", "these", "C1417679#ent", "<e1>", "are", "important", "regulators", "of", "apoptotic", "pathways", "DAD1", ",", "APO3", ",", "C1420468#ent", "<e2>", "or", "BIK", ")", ",", "suggesting", "that", "this", "process", "could", "be", "associated", "with", "node", "involvement", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420468", "name": "C1420468#ent", "pos": [15, 16]}}
{"token": ["Absolute", "C1420709#ent", "<e1>", "decreases", "after", "C1415467#ent", "<e2>", "supplementation", "were", "inversely", "correlated", "to", "baseline", "C1420709#ent", "<e1>", "concentrations", "(", "r", "-0.627", ",", "P<0.001", ")", "."], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [1, 2]}}
{"token": ["To", "understand", "the", "role", "of", "C2697647#ent", "<e1>", "in", "T-cell", "development", ",", "we", "used", "a", "retroviral", "vector", "express", "full-length", "C2697647#ent", "<e1>", "or", "a", "C0597298#ent", "<e1>", "lacked", "the", "N-terminal", "DNA-binding", "domain", "in", "hematopoietic", "progenitor", "cells", "reconstituted", "mice"], "h": {"id": "C2697647", "name": "C2697647#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "C0242287#ent", "<e1>", "bound", "more", "strongly", "to", "Kv1.2", "subunits", "than", "to", "C1416543#ent", "<e2>", "or", "Kv1.6", "."], "h": {"id": "C0242287", "name": "C0242287#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416543", "name": "C1416543#ent", "pos": [13, 14]}}
{"token": ["Episodic", "ataxia", "type-1", "EA1", ")", "is", "a", "human", "neurological", "syndrome", "characterized", "by", "attacks", "of", "generalized", "ataxia", "by", "C0242287#ent", "<e1>", "has", "been", "associated", "with", "mutations", "in", "the", "voltage-gated", "potassium", "channel", "gene", "C1416543#ent", "<e2>", "."], "h": {"id": "C0242287", "name": "C0242287#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416543", "name": "C1416543#ent", "pos": [30, 31]}}
{"token": ["A", "42-yr-old", "woman", "with", "C0011633#ent", "<e1>", "had", "two", "myocardial", "infarctions", "episodes", "of", "C0008031#ent", "<e2>", "an", "acute", "lung", "oedema"], "h": {"id": "C0011633", "name": "C0011633#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008031", "name": "C0008031#ent", "pos": [12, 13]}}
{"token": ["Abnormal", "fluid", "accumulation", "in", "tissues", ",", "including", "the", "life-threatening", "cerebral", "and", "C0034063#ent", "<e1>", "is", "a", "severe", "consequence", "of", "C0004623#ent", "<e2>"], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [18, 19]}}
{"token": ["Loss", "of", "hearing", "ability", "pervades", "C3274826#ent", "<e1>", "function", "in", "aged", "individuals", ",", "decreasing", "activity", ",", "increasing", "C0086132#ent", "<e2>", "and", "confounding", "assessment", "of", "cognitive", "ability"], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086132", "name": "C0086132#ent", "pos": [16, 17]}}
{"token": ["In", "a", "randomised", ",", "double-blind", "study", "123", "patients", ",", "risedronate", "30", "mg/day", "for", "2", "months", "evoked", "significantly", "greater", "serum", "C1427121#ent", "<e1>", "responses", "than", "C0086268#ent", "<e2>", "400", "mg/day", "for", "6", "months", "."], "h": {"id": "C1427121", "name": "C1427121#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0086268", "name": "C0086268#ent", "pos": [23, 24]}}
{"token": ["The", "C0033681#ent", "<e1>", "phosphorylate", "Src", "at", "C0041484#ent", "<e2>", "527", "in", "vivo", "not", "been", "identified", ",", "but", "a", "tyrosine", "kinase", "as", "CSK", "is", "an", "excellent", "candidate", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041484", "name": "C0041484#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "the", "yeast", "C1418640#ent", "<e1>", "deletion", "mutant", "lacking", "phosphoinositide-specific", "phospholipase", "C", "a", "key", "C0014442#ent", "<e2>", "for", "generating", "Ca2", "+", "signals", "in", "higher", "eukaryotic", "cells", "responds", "normally", "to", "the", "pheromone", "."], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["C0235025#ent", "<e1>", "seen", "in", "54", "%", "secondary", "to", "C0042679#ent", "<e2>", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [8, 9]}}
{"token": ["All", "tumor", "tissues", "with", "C3273407#ent", "<e1>", ",", "but", "they", "did", "not", "react", "with", "L26", "(", "C1706319#ent", "<e2>", ")", ",", "4KB5", "(", "CD45R", ")", ",", "MT-1", ",", "and", "leukocyte", "common", "antigen", "LCA", ")", "."], "h": {"id": "C3273407", "name": "C3273407#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706319", "name": "C1706319#ent", "pos": [15, 16]}}
{"token": ["These", "data", "suggest", "that", "C3887563#ent", "<e1>", "has", "a", "different", "function", "from", "C1412291#ent", "<e2>", "and", "plays", "an", "important", "role", "in", "embryogenesis", "by", "modulating", "inositol", "1,4,5-trisphosphate", "receptor", "function", "the", "intracellular", "calcium", "release"], "h": {"id": "C3887563", "name": "C3887563#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412291", "name": "C1412291#ent", "pos": [11, 12]}}
{"token": ["C3540811#ent", "<e1>", "constitutively", "express", "MEKK1", ",", "MEKK2", ",", "MEKK3", ",", "and", "C3812805#ent", "<e2>", "and", "that", "their", "levels", "are", "unaffected", "by", "TNF-alpha", "or", "alpha-LA", "."], "h": {"id": "C3540811", "name": "C3540811#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3812805", "name": "C3812805#ent", "pos": [11, 12]}}
{"token": ["Western", "blot", "analysis", "C3540811#ent", "<e1>", "demonstrated", "that", "MEKK1", ",", "MEKK2", ",", "and", "C3812805#ent", "<e2>", "were", "readily", "detectable", "and", "were", "subsequently", "the", "focus", "of", "functional", "studies", "."], "h": {"id": "C3540811", "name": "C3540811#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3812805", "name": "C3812805#ent", "pos": [12, 13]}}
{"token": ["Of", "interest", ",", "MEKK1", "immunoprecipitates", "from", "IL-1-stimulated", "C3540811#ent", "<e1>", "appeared", "to", "activate", "c-Jun", "through", "the", "JNK", "pathway", "C3812805#ent", "<e2>", "activation", "of", "c-Jun", "was", "dependent", "on", "JNK", ",", "ERK", ",", "and", "p38", "."], "h": {"id": "C3540811", "name": "C3540811#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3812805", "name": "C3812805#ent", "pos": [17, 18]}}
{"token": ["Their", "chief", "complaints", "C0003862#ent", "<e1>", "or", "coxalgia", ",", "however", ",", "any", "pain", "or", "C0162298#ent", "<e2>", "in", "lumbar", "regions", "absent", "."], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162298", "name": "C0162298#ent", "pos": [13, 14]}}
{"token": ["In", "support", "of", "its", "specificity", "for", "C1955862#ent", "<e1>", "glibenclamide", "did", "not", "reverse", "C0280858#ent", "<e2>", "induced", "dilation", "in", "a", "separate", "series", "of", "experiments", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [12, 13]}}
{"token": ["The", "recently", "isolated", "and", "purified", "C0162745#ent", "<e1>", "produced", "by", "Achromobacter", "iophagus", "the", "C0162745#ent", "<e1>", "from", "C0009053#ent", "<e1>", "and", "thermolysin", ",", "three", "enzymes", "having", "common", "properties", ",", "were", "studied", "by", "circular", "dichroism"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0009053", "name": "C0009053#ent", "pos": [15, 16]}}
{"token": ["In", "the", "area", "of", "parasitic", "diseases", "has", "been", "directed", "especially", "to", "immunodiagnosis", "of", "helminthic", "diseases", "including", "C0018013#ent", "<e1>", ",", "paragonimiasis", ",", "opisthorchiasis", ",", "C0040947#ent", "<e2>", "and", "trichinellosis", "."], "h": {"id": "C0018013", "name": "C0018013#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0040947", "name": "C0040947#ent", "pos": [23, 24]}}
{"token": ["The", "results", "indicated", "that", "C0065180#ent", "<e1>", "was", "metabolized", "to", "DCL", "primarily", "by", "the", "C1142644#ent", "<e2>", "and", "CYP2D6", "enzymes", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0065180", "name": "C0065180#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [13, 14]}}
{"token": ["C0065180#ent", "<e1>", "is", "known", "to", "be", "a", "substrate", "for", "both", "C1142644#ent", "<e2>", "and", "CYP2D6", "based", "on", "a", "previous", "in", "vitro", "study", "."], "h": {"id": "C0065180", "name": "C0065180#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [10, 11]}}
{"token": ["The", "model", "was", "further", "extended", "to", "incorporate", "the", "responses", "to", "C0913506#ent", "<e1>", "in", "the", "presence", "of", "the", "5-HT4", "receptor", "antagonist", "C0219493#ent", "<e2>", "(", "[", "1-[2-[(methylsulphonyl)amino]ethyl]-4-piperidinyl-]methyl", "1-methyl-1H-indole-3-carboxylate", ")", "."], "h": {"id": "C0913506", "name": "C0913506#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0219493", "name": "C0219493#ent", "pos": [20, 21]}}
{"token": ["All", "effects", "of", "C0913506#ent", "<e1>", "were", "antagonized", "by", "the", "selective", "5-HT4", "receptor", "antagonist", "C0219493#ent", "<e2>", "."], "h": {"id": "C0913506", "name": "C0913506#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0219493", "name": "C0219493#ent", "pos": [13, 14]}}
{"token": ["The", "cardiostimulant", "effects", "of", "C0913506#ent", "<e1>", "were", "prevented", "by", "C0219493#ent", "<e2>", "(", "1", "microM", ")", ",", "consistent", "with", "mediation", "through", "5-HT4", "receptors"], "h": {"id": "C0913506", "name": "C0913506#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0219493", "name": "C0219493#ent", "pos": [9, 10]}}
{"token": ["In", "15", "type", "I", "diabetics", "with", "manifest", "C0011881#ent", "<e1>", "authors", "investigated", "the", "antihypertensive", "and", "antiproteinuric", "effect", "of", "C0006938#ent", "<e2>", "and", "in", "seven", "patients", "of", "this", "group", "also", "its", "effect", "on", "renal", "haemodynamics"], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [17, 18]}}
{"token": ["Advanced", "glycation", "end-product", "AGE", ")", "is", "important", "in", "the", "pathogenesis", "of", "C0011881#ent", "<e1>", "DN", ")", ",", "and", "C0006938#ent", "<e2>", "(", "an", "angiotensin", "converting", "enzyme", "inhibitor", "is", "effective", "in", "treating", "this", "disorder", "."], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [11, 12]}, "relation": "may_be_prevented_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "the", "changes", "related", "to", "C0011881#ent", "<e1>", "the", "body", "weight", "also", "significantly", "lower", "in", "the", "C0006938#ent", "<e2>", "and", "all", "PR", "extract-dosing", "groups", "than", "in", "the", "diabetic", "control", "."], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [17, 18]}}
{"token": ["We", "suggest", "that", "increased", "C1366631#ent", "<e1>", ",", "an", "attendant", "increase", "in", "C2698414#ent", "<e2>", "and", "increased", "AII", "type", "1", "receptor", "podocytes", "experiencing", "diabetic", "conditions", "play", "an", "important", "role", "in", "the", "pathogenesis", "of", "diabetic", "nephropathy"], "h": {"id": "C1366631", "name": "C1366631#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [11, 12]}}
{"token": ["Patients", "who", "do", "develop", "nausea", "will", "require", "C0003297#ent", "<e1>", "treatment", "with", "an", "antipsychotic", ",", "C1268865#ent", "<e2>", "or", "serotonin", "antagonist"], "h": {"id": "C0003297", "name": "C0003297#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1268865", "name": "C1268865#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrate", "that", "in", "addition", "to", "tyrosine", "kinases", "Lyn", "and", "C1528376#ent", "<e1>", ",", "FcalphaR", "cross-linking", "also", "recruits", "B-lymphocyte", "kinase", "Blk", ")", "and", "C1698931#ent", "<e2>", "Syk", ")", "to", "rafts", "."], "h": {"id": "C1528376", "name": "C1528376#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1698931", "name": "C1698931#ent", "pos": [22, 23]}}
{"token": ["Moreover", ",", "C1420423#ent", "<e1>", "lacking", "the", "SBM", "does", "not", "localize", "to", "C1417613#ent", "<e2>", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [11, 12]}}
{"token": ["Affinity", "purification", "native", "immunoprecipitation", "of", "C1420423#ent", "<e1>", "and", "fluorescence", "resonance", "energy", "transfer", "the", "nucleolus", "reveal", "close", "association", "with", "C1417613#ent", "<e2>", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [18, 19]}}
{"token": ["Later", "analyses", "revealed", "the", "presence", "of", "fibrillarin", ",", "nucleoporin", "p62", "and", "C1420423#ent", "<e1>", "in", "BIG1", "and", "C1417613#ent", "<e2>", "immunoprecipitates", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [16, 17]}}
{"token": ["The", "glucagon", "response", "to", "C0020615#ent", "<e1>", "was", "augmented", "by", "C0301336#ent", "<e2>", "the", "data", "were", "expressed", "as", "the", "incremental", "area", "the", "glucagon", "vs.", "time", "curve", "but", "not", "when", "peak", "response", "used", "for", "analysis", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0301336", "name": "C0301336#ent", "pos": [9, 10]}}
{"token": ["To", "have", "seven", "cases", "of", "C0032302#ent", "<e1>", "liver", "abscess", "complicated", "by", "C0014238#ent", "<e2>", "a", "period", "of", "four", "years", "in", "one", "hospital", "is", "very", "unusual", "."], "h": {"id": "C0032302", "name": "C0032302#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014238", "name": "C0014238#ent", "pos": [11, 12]}}
{"token": ["A", "novel", "C3539765#ent", "<e1>", "differing", "from", "Dmc1", "and", "C1419240#ent", "<e2>", ",", "was", "characterized", "in", "Oryza", "sativa", "L.", "cv"], "h": {"id": "C3539765", "name": "C3539765#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419240", "name": "C1419240#ent", "pos": [8, 9]}}
{"token": ["Rlp1", "shows", "homology", "to", "C3539765#ent", "<e1>", "and", "is", "the", "third", "S.", "pombe", "C1419240#ent", "<e2>", "paralog", "besides", "Rhp55", "and", "Rhp57", "."], "h": {"id": "C3539765", "name": "C3539765#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419240", "name": "C1419240#ent", "pos": [12, 13]}}
{"token": ["For", "brief", "presentations", "only", "the", "C0720099#ent", "<e1>", "of", "high", "C1704887#ent", "<e2>", "gratings", "was", "subjectively", "shorter", "than", "the", "C0720099#ent", "<e1>", "of", "low", "C1704887#ent", "<e2>", "gratings", "."], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [5, 6]}}
{"token": ["Subjective", "duration", "decreased", "with", "the", "increase", "of", "C1704887#ent", "<e1>", "under", "both", "experimental", "conditions", "was", "concluded", "that", "retinal", "persistence", "does", "not", "underlie", "the", "C1704887#ent", "<e1>", "effect", "on", "brief", "C0720099#ent", "<e1>", "perception", "."], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [27, 28]}}
{"token": ["C0085170#ent", "<e1>", "was", "superior", "to", "placebo", "and", "the", "classical", "antihistamines", "C0546858#ent", "<e2>", ",", "Terfenadine", ",", "Ketotifen", ",", "Mequitazine", ",", "pheniramine", "and", "Chlorphenamine", "."], "h": {"id": "C0085170", "name": "C0085170#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0546858", "name": "C0546858#ent", "pos": [10, 11]}}
{"token": ["They", "were", "characterized", "by", "genomic", "analysis", "hybridization", "studies", "reversion", "to", "C2987364#ent", "<e1>", "in", "vivo", "recombination", ",", "and", "rescue", "from", "their", "C0242965#ent", "<e2>", "of", "plasmids", "which", "contained", "all", "or", "parts", "of", "the", "pBR322", "sequence", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [20, 21]}}
{"token": ["Benzyl", "esters", ",", "corresponding", "to", "the", "usual", "ethyl/methyl", "esters", "of", "the", "C1367701#ent", "<e1>", "developed", "as", "C0006684#ent", "<e2>", "retained", "potency", "at", "SOC", "channels", "as", "did", "N-substituted", "C1367701#ent", "<e1>", "."], "h": {"id": "C1367701", "name": "C1367701#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [15, 16]}}
{"token": ["Dihydropyridines", "(", "C1367701#ent", "<e1>", ")", ",", "a", "type", "of", "C0006684#ent", "<e2>", "CCB", ")", ",", "are", "commonly", "prescribed", "for", "the", "treatment", "of", "hypertension", "and", "angina", "pectoris"], "h": {"id": "C1367701", "name": "C1367701#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [9, 10]}}
{"token": ["These", "data", "demonstrate", "that", "Foxe3", "is", "necessary", "for", "lens", "development", "zebrafish", "and", "that", "C1414676#ent", "<e1>", "lies", "genetically", "downstream", "of", "C1418597#ent", "<e2>", "in", "a", "zebrafish", "lens", "development", "pathway"], "h": {"id": "C1414676", "name": "C1414676#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418597", "name": "C1418597#ent", "pos": [19, 20]}}
{"token": ["In", "order", "to", "characterize", "the", "developmental", "expression", "pattern", "of", "C0752120#ent", "<e1>", "and", "to", "identify", "putative", "functional", "domains", "ataxin-1", ",", "the", "C1334043#ent", "<e2>", "Sca1", ")", "was", "isolated", "."], "h": {"id": "C0752120", "name": "C0752120#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "multimorbid", "patient", "with", "C2316810#ent", "<e1>", "a", "large", "necrosis", "and", "C0085642#ent", "<e2>", "the", "right", "thigh"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085642", "name": "C0085642#ent", "pos": [12, 13]}}
{"token": ["The", "patient's", "findings", "were", "compatible", "with", "a", "rare", "C0039082#ent", "<e1>", "designated", "as", "type", "II", "pseudohypoaldosteronism", "C0220666#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0220666", "name": "C0220666#ent", "pos": [15, 16]}}
{"token": ["The", "C0039082#ent", "<e1>", "of", "hypertension", "and", "hyperkalemia", ",", "hyperchloremic", "acidosis", "normal", "glomerular", "filtration", "rate", "C0220666#ent", "<e2>", "is", "characterised", "by", "volume", "expansion", "suppressed", "renin", "and", "reduced", "mineralocorticoid-induced", "renal", "clearance", "of", "potassium", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0220666", "name": "C0220666#ent", "pos": [14, 15]}}
{"token": ["C1720911#ent", "<e1>", "are", "phosphatase", "(", "C1418858#ent", "<e2>", "and", "PP2A", ")", "inhibitors", "and", "cause", "animal", "death", "alteration", "of", "the", "liver", "cell", "cytoskeletons", "and", "intrahepatic", "hemorrhage"], "h": {"id": "C1720911", "name": "C1720911#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418858", "name": "C1418858#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "the", "substitution", "of", "alanine", "(", "-LA", ")", "for", "arginine", "(", "-LR", ")", "in", "C1720911#ent", "<e1>", "has", "no", "apparent", "effect", "on", "the", "inhibitory", "activity", "C1418858#ent", "<e2>", ",", "PP2A", "or", "PP3", "."], "h": {"id": "C1720911", "name": "C1720911#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418858", "name": "C1418858#ent", "pos": [26, 27]}}
{"token": ["These", "results", "emphasize", "the", "involvement", "of", "two", "infundibular", "neurosecretory", "systems", "C2827446#ent", "<e1>", "and", "VLI", "--", "in", "the", "regulation", "of", "the", "C0032002#ent", "<e2>", "--", "adrenal", "axis"], "h": {"id": "C2827446", "name": "C2827446#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [20, 21]}}
{"token": ["The", "drugs", "examined", "were", "flumazenil", ",", "butorphanol", ",", "C1161352#ent", "<e1>", ",", "ketamine", ",", "xylazine", ",", "C0125656#ent", "<e2>", ",", "atipamezole", "and", "midazolam", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0125656", "name": "C0125656#ent", "pos": [15, 16]}}
{"token": ["C1161352#ent", "<e1>", "prevented", "the", "bradyarrhythmia", "and", "bradycardia", "induced", "by", "C0125656#ent", "<e2>", ",", "but", "it", "induced", "a", "tachycardia", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0125656", "name": "C0125656#ent", "pos": [9, 10]}}
{"token": ["In", "21", "patients", "with", "C1956346#ent", "<e1>", "influence", "of", "cardiac", "failure", "the", "elimination", "of", "C0023660#ent", "<e2>", "(", "L", ")", "was", "evaluated", "by", "repeated", "serum", "level", "measurements", "during", "and", "after", "a", "therapeutic", "L-infusion", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [13, 14]}}
{"token": ["Other", "C1421450#ent", "<e1>", "neurons", ",", "containing", "markers", "of", "glutamate", "or", "C3536742#ent", "<e2>", "synthesis", ",", "were", "insensitive", "to", "baroreceptor", "stimulation", "."], "h": {"id": "C1421450", "name": "C1421450#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [10, 11]}}
{"token": ["Thus", "the", "mutations", "C0011860#ent", "<e1>", "and", "rpb", "permit", "the", "C0041658#ent", "<e2>", "two", "phenotypes", "induced", "by", "the", "mutation", "petD."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041658", "name": "C0041658#ent", "pos": [9, 10]}}
{"token": ["This", "paper", "describes", "four", "cases", "(", "where", "C0038013#ent", "<e1>", "the", "basic", "C0221423#ent", "<e2>", "of", "the", "patients", "involved", ")", "of", "immune", "complex", "nephritis", "stage", "I", "membranous", "glomerulonephritis", "respectively", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [11, 12]}}
{"token": ["C0038013#ent", "<e1>", "many", "other", "systemic", "rheumatic", "diseases", "C0221423#ent", "<e2>", "of", "unknown", "cause", "for", "which", "current", "therapy", "is", "often", "inadequate", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [7, 8]}}
{"token": ["The", "major", "etiologic", "risk", "factors", "HCC", "development", "include", "hepatitis", "B", "virus", "HBV", ")", "and", "hepatitis", "C", "virus", "HCV", ")", "infection", ",", "toxins", "(", "alcohol", ",", "aflatoxin", "B1", "and", "various", "inherited", "C0025517#ent", "<e1>", "such", "as", "C0018995#ent", "<e2>", "and", "alpha-1-antitrypsin", "deficiency"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [30, 31]}, "relation": "related_to", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [34, 35]}}
{"token": ["H2O2-induced", "changes", "in", "C0909826#ent", "<e1>", "localization", "were", "abolished", "by", "C0297666#ent", "<e2>", "pretreatment", "as", "well", "as", "Wip1-expressing", "adenovirus", "infection", "."], "h": {"id": "C0909826", "name": "C0909826#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0297666", "name": "C0297666#ent", "pos": [9, 10]}}
{"token": ["The", "results", "of", "this", "study", "suggest", "that", "BstUI", "and", "C1833662#ent", "<e1>", "polymorphisms", "of", "the", "C0079419#ent", "<e2>", "modify", "the", "risk", "of", "bladder", "cancer"], "h": {"id": "C1833662", "name": "C1833662#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079419", "name": "C0079419#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "review", ",", "we", "summarize", "the", "recent", "evolution", "of", "our", "understanding", "of", "the", "function", "of", "two", "histone", "acetyl", "transferases", "C2347281#ent", "<e1>", ")", "from", "metazoan", "organisms", ":", "C1366462#ent", "<e2>", "and", "PCAF", "."], "h": {"id": "C2347281", "name": "C2347281#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1366462", "name": "C1366462#ent", "pos": [28, 29]}}
{"token": ["Wild-type", "Arabidopsis", "treated", "with", "PBZ", "or", "BIT", "exhibited", "increased", "expression", "of", "several", "C1425234#ent", "<e1>", "increased", "levels", "of", "C0073983#ent", "<e2>", "SA", ")", ",", "and", "enhanced", "resistance", "to", "the", "bacterial", "pathogen", "Pseudomonas", "syringae", "pv"], "h": {"id": "C1425234", "name": "C1425234#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0073983", "name": "C0073983#ent", "pos": [17, 18]}}
{"token": ["Hepatic", "lipase", "HL", ")", "and", "C1447747#ent", "<e1>", "EL", ")", "are", "both", "members", "of", "the", "C0023764#ent", "<e2>"], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0023764", "name": "C0023764#ent", "pos": [14, 15]}}
{"token": ["C1447747#ent", "<e1>", "EL", ")", "is", "a", "member", "of", "the", "C0023764#ent", "<e2>", "high", "phospholipase", "low", "triacylglycerol", "lipase", "activities", "and", "a", "distinct", "preference", "for", "hydrolyzing", "phospholipids", "in", "HDL", "."], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0023764", "name": "C0023764#ent", "pos": [9, 10]}}
{"token": ["These", "findings", "support", "the", "notion", "that", "C3815276#ent", "<e1>", "can", "act", "as", "a", "general", "modulator", "of", "remote", "docking", "sites", "C0010536#ent", "<e2>", "substrate", "interactions", "."], "h": {"id": "C3815276", "name": "C3815276#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [18, 19]}}
{"token": ["Bath", "and", "intra-arterial", "application", "of", "C0022816#ent", "<e1>", "KYN", ")", "or", "D", ",", "L-2-amino-5-phosphonovaleric", "acid", "C0754188#ent", "<e2>", ")", "suppressed", "the", "rhythm", "."], "h": {"id": "C0022816", "name": "C0022816#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0754188", "name": "C0754188#ent", "pos": [14, 15]}}
{"token": ["C1417500#ent", "<e1>", "+", "also", "affects", "Em", "and", "C1418829#ent", "<e2>", ",", "but", "its", "effect", "is", "probably", "on", "GH", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418829", "name": "C1418829#ent", "pos": [7, 8]}}
{"token": ["In", "an", "expanded", "case", "set", "C0796518#ent", "<e1>", "continued", "to", "show", "significant", "overtransmission", "of", "an", "C1706112#ent", "<e2>", "to", "the", "fetus", ",", "with", "a", "final", "P", "value", "of", ".00003", "."], "h": {"id": "C0796518", "name": "C0796518#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [14, 15]}}
{"token": ["The", "major", "grass", "group", "I", "allergen", "from", "timothy", "grass", "Phleum", "pratense", ",", "C0105421#ent", "<e1>", "was", "chosen", "as", "a", "C0072522#ent", "<e2>", "expressed", "in", "the", "methylotrophic", "yeast", "Pichia", "pastoris", "to", "obtain", "a", "post-translationally", "modified", "functionally", "active", "allergen", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "plasma", "C3539565#ent", "<e1>", "levels", "and", "C3539565#ent", "<e1>", "C1868677#ent", "<e1>", "in", "sheep", "were", "more", "sensitive", "to", "the", "effects", "of", "deflazacort", "than", "to", "prednisolone", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1868677", "name": "C1868677#ent", "pos": [10, 11]}}
{"token": ["C0012010#ent", "<e1>", "binding", "inhibitor", "luminal", "CCK-releasing", "factor", "are", "likely", "candidates", "for", "CCK-releasing", "C0030956#ent", "<e2>", "in", "the", "negative", "feedback", "process", "the", "absence", "of", "pancreatic", "juice"], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "impulse", "activity", "examined", "more", "directly", "in", "adults", "by", "treatment", "with", "the", "C0035064#ent", "<e1>", "reserpine", "or", "C0242430#ent", "<e2>", ",", "which", "elicit", "reflex", "increases", "in", "sympathetic", "transmission"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0242430", "name": "C0242430#ent", "pos": [18, 19]}}
{"token": ["These", "results", "support", "the", "in", "vivo", "evidence", "which", "indicates", "that", "C1705548#ent", "<e1>", "and", "LH", "induction", "are", "not", "causally", "linked", "to", "the", "C0542037#ent", "<e2>", "actions", "of", "peroxisome", "proliferating", "drugs"], "h": {"id": "C1705548", "name": "C1705548#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0542037", "name": "C0542037#ent", "pos": [21, 22]}}
{"token": ["Positional", "cloning", "the", "translocation", "breakpoint", "chromosome", "13", "in", "the", "mapping", "of", "the", "breakpoint", "between", "coding", "exon", "2", "and", "exon", "3", "C1421481#ent", "<e1>", ",", "a", "member", "of", "C1517488#ent", "<e2>"], "h": {"id": "C1421481", "name": "C1421481#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [26, 27]}}
{"token": ["Because", "C1415097#ent", "<e1>", "exert", "their", "anti-inflammatory", "effects", "binding", "to", "intracellular", "glucocorticoid", "receptors", "C1412761#ent", "<e2>", ")", ",", "we", "examined", "the", "role", "of", "the", "GR", "in", "facilitating", "the", "anti-inflammatory", "effects", "of", "exercise", "."], "h": {"id": "C1415097", "name": "C1415097#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412761", "name": "C1412761#ent", "pos": [12, 13]}}
{"token": ["In", "C0004096#ent", "<e1>", "children", "with", "persistent", "symptoms", ",", "maintenance", "therapy", "C0068483#ent", "<e2>", "inhaled", "corticosteroids", "or", "montelukast", "is", "associated", "with", "decreased", "rate", "of", "asthma", "exacerbations", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [1, 2]}, "relation": "may_be_prevented_by", "t": {"id": "C0068483", "name": "C0068483#ent", "pos": [10, 11]}}
{"token": ["There", "was", "no", "significant", "difference", "of", "antibody", "isotype", "cytokine", "production", "between", "C0004096#ent", "<e1>", "subjects", "receiving", "treatment", "with", "budesonide", "or", "C0068483#ent", "<e2>", ",", "as", "compared", "to", "placebo", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}, "relation": "may_be_prevented_by", "t": {"id": "C0068483", "name": "C0068483#ent", "pos": [19, 20]}}
{"token": ["Moreover", ",", "the", "dominant-negative", "SRF", "inhibited", "C0242912#ent", "<e1>", "against", "trophic", "withdrawal", "afforded", "by", "expression", "of", "a", "C0669365#ent", "<e2>", "active", "PI3K"], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [16, 17]}}
{"token": ["The", "mitochondrial", "DNA", "M.", "graminicola", "lacks", "the", "C0079429#ent", "<e1>", "encoding", "the", "C1539696#ent", "<e2>", "rps5-like", ")", ",", "commonly", "found", "in", "fungal", "mitochondrial", "genomes"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [11, 12]}}
{"token": ["The", "temperature-sensitive", "mutation", "rna2", "causes", "the", "accumulation", "of", "higher", "molecular", "weight", "transcripts", "from", "the", "ribosomal", "protein", "51", "rp51", ")", "C0079429#ent", "<e1>", "of", "yeast", "and", "many", "other", "C1539696#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [26, 27]}}
{"token": ["During", "renal", "pelvic", "administration", "of", "the", "neutral", "endopeptidase", "inhibitor", "C0039945#ent", "<e1>", ",", "the", "afferent", "renal", "nerve", "response", "to", "substance", "P", "plus", "C1704715#ent", "<e2>", "was", "similar", "to", "that", "produced", "by", "either", "neuropeptide", "alone", "."], "h": {"id": "C0039945", "name": "C0039945#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704715", "name": "C1704715#ent", "pos": [21, 22]}}
{"token": ["shaggy", "is", "also", "required", "for", "the", "lateral", "signal", "encodes", "C1413288#ent", "<e1>", "homology", "to", "the", "C4283740#ent", "<e2>", "GSK-3", ")", "enzymes", "that", "act", "in", "signal", "transduction", "pathways", "vertebrates", "."], "h": {"id": "C1413288", "name": "C1413288#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [14, 15]}}
{"token": ["The", "spin-labeled", "substrate", ",", "tryptamine", ",", "was", "used", "as", "a", "structural", "probe", "the", "active", "site", "bovine", "liver", "C1417002#ent", "<e1>", "amine", ":", "oxygen", "oxidoreductase", "deaminating", ")", "(", "flavin-containing", ")", ",", "C4084845#ent", "<e2>", "."], "h": {"id": "C1417002", "name": "C1417002#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4084845", "name": "C4084845#ent", "pos": [29, 30]}}
{"token": ["Optimal", "conditions", "for", "VLDL", "lipolysis", "by", "HSPG-bound", "LPL", "were", "obtained", "by", "incubating", "plastic", "wells", "0.5", "microg", "C2987155#ent", "<e1>", "and", "1.5", "microg", "C0023816#ent", "<e2>", ",", "subsequently", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [21, 22]}}
{"token": ["These", "findings", "indicated", "its", "potential", "usefulness", "of", "this", "method", "for", "measuring", "small", "amounts", "C2987155#ent", "<e1>", "capable", "of", "binding", "to", "C0023816#ent", "<e2>", "and", "for", "studying", "biological", "implications", "of", "C2987155#ent", "<e1>", "-", "C0023816#ent", "<e2>", "interaction", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [19, 20]}}
{"token": ["C0074554#ent", "<e1>", "stimulated", "the", "expression", "of", "scavenger", "receptor", "class", "B", "type", "I", "C3540050#ent", "<e2>", ")", "and", "endothelial", "NOS"], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540050", "name": "C3540050#ent", "pos": [12, 13]}}
{"token": ["Collagen", "metabolism", "studied", "in", "C0008475#ent", "<e1>", "dogs", "with", "spontaneous", ",", "early", "onset", "C0949690#ent", "<e2>", "."], "h": {"id": "C0008475", "name": "C0008475#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [12, 13]}}
{"token": ["Eight", "had", "symptomatic", "osteochondritis", ",", "31", "had", "C0008475#ent", "<e1>", "57", "had", "early", "C0949690#ent", "<e2>", "."], "h": {"id": "C0008475", "name": "C0008475#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "C0008475#ent", "<e1>", "does", "not", "easily", "lead", "to", "C0949690#ent", "<e2>", "."], "h": {"id": "C0008475", "name": "C0008475#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [10, 11]}}
{"token": ["It", "is", "shown", "that", "this", "scenario", "explains", "the", "optical-Kerr-effect", "data", "measured", "for", "C0073999#ent", "<e1>", "and", "benzophenone", "(", "C3538848#ent", "<e2>", ")", "."], "h": {"id": "C0073999", "name": "C0073999#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3538848", "name": "C3538848#ent", "pos": [17, 18]}}
{"token": ["In", "overnight", "fasted", "animals", "C1417815#ent", "<e1>", "injections", "produced", "C1704793#ent", "<e2>", "responses", "of", "equal", "magnitude", "to", "those", "in", "ad", "lib", "animals.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "C1417815#ent", "<e1>", "on", "the", "C1704793#ent", "<e2>", "response", "appeared", "to", "be", "mediated", "by", "changes", "in", "the", "cAMP", "response"], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [7, 8]}}
{"token": ["C3827767#ent", "<e1>", "suppressed", "reactive", "oxygen", "species", "generation", "and", "p38", "mitogen-activated", "protein", "kinase", "activation", "restoring", "C0812234#ent", "<e2>", "signaling", "activity", "."], "h": {"id": "C3827767", "name": "C3827767#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [14, 15]}}
{"token": ["A", "28-year-old", "woman", "developed", "spontaneously", "a", "C0032326#ent", "<e1>", "the", "leading", "clinical", "symptom", "an", "as", "yet", "undiagnosed", "C0036421#ent", "<e2>"], "h": {"id": "C0032326", "name": "C0032326#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [16, 17]}}
{"token": ["Silver", ",", "ruthenium", ",", "cobalt", ",", "C1166521#ent", "<e1>", ",", "zinc", ",", "cadmium", "and", "mercury", "are", "determined", "in", "C1171558#ent", "<e2>", "by", "neutron-activation", "analysis"], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1171558", "name": "C1171558#ent", "pos": [17, 18]}}
{"token": ["Animals", "with", "low", "C1413353#ent", "<e1>", "and", "high", "LPL", "activities", "appear", "to", "be", "more", "sensitive", "to", "C0218076#ent", "<e2>", "than", "those", "with", "high", "C1413353#ent", "<e1>", "and", "low", "LPL", "activities", "."], "h": {"id": "C0218076", "name": "C0218076#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1413353", "name": "C1413353#ent", "pos": [3, 4]}}
{"token": ["Peptide-specific", "T-cell", "lines", "and", "clones", "were", "generated", "with", "cells", "from", "nonimmunized", "donors", "homozygous", "for", "C1333247#ent", "<e1>", "or", "DR103", "by", "using", "either", "individual", "C0030956#ent", "<e2>", "or", "peptide", "pools", "for", "the", "in", "vitro", "priming", "."], "h": {"id": "C1333247", "name": "C1333247#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [22, 23]}}
{"token": ["The", "Class", "IV", "agent", "C0042523#ent", "<e1>", ",", "which", "is", "a", "calcium", "channel", "blocker", "has", "potent", "myocardial", "C0007681#ent", "<e2>", "actions", "and", "causes", "peripheral", "vasodilatation"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [16, 17]}}
{"token": ["C0042523#ent", "<e1>", "also", "had", "a", "direct", "myocardial", "C0007681#ent", "<e2>", "action", "which", "became", "evident", "at", "doses", "above", "the", "range", "used", "clinically", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [7, 8]}}
{"token": ["The", "influence", "of", "propranolol", ",", "nifedipine", ",", "or", "C0042523#ent", "<e1>", "pretreatment", "on", "the", "myocardial", "C0007681#ent", "<e2>", "effect", "of", "cocaine", "was", "examined", "in", "13", "chronically", "instrumented", ",", "conscious", "dogs"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [14, 15]}}
{"token": ["Conversely", ",", "specific", "inhibitors", "for", "C1366876#ent", "<e1>", "and", "JNK", "blocked", "C1423842#ent", "<e2>", "deviation", "in", "the", "same", "T", "cell", "induced", "by", "peptide", "86A", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [10, 11]}}
{"token": ["C0041296#ent", "<e1>", "is", "nowadays", "an", "uncommon", "cause", "of", "C0038833#ent", "<e2>", "SVCS", ")", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038833", "name": "C0038833#ent", "pos": [8, 9]}}
{"token": ["This", "function", "of", "C1418747#ent", "<e1>", "is", "not", "affected", "by", "any", "pathways", "of", "nucleotide", "excision", "repair", "including", "TCR", "mediated", "by", "C1418747#ent", "<e1>", "itself", "and", "by", "C1366757#ent", "<e1>", "."], "h": {"id": "C1418747", "name": "C1418747#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366757", "name": "C1366757#ent", "pos": [24, 25]}}
{"token": ["2,3,7,8-Tetrachlorodibenzo-p-dioxin", "(", "TCDD", ")", "induces", "C3252639#ent", "<e1>", "as", "determined", "by", "increased", "C3252639#ent", "<e1>", "mRNA", "levels", "and", "ethoxyresorufin", "O-deethylase", "EROD", ")", "activity", "in", "mouse", "Hepa", "1c1c7", ",", "rat", "hepatoma", "H-4II", "E", "and", "human", "Hep", "G2", "cancer", "cell", "lines"], "h": {"id": "C3252639", "name": "C3252639#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3252639", "name": "C3252639#ent", "pos": [5, 6]}}
{"token": ["The", "findings", "show", "some", "typical", "features", "of", "the", "weak", "antibody", "response", "a", "C0042769#ent", "<e1>", "suggest", "a", "serological", "overlapping", "between", "C0009663#ent", "<e2>", "certain", "group", "of", "skin", "wart-viruses", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0009663", "name": "C0009663#ent", "pos": [19, 20]}}
{"token": ["Endolymphatic", "sac", "tumors", "ELSTs", ")", "are", "associated", "with", "C0019562#ent", "<e1>", "cause", "irreversible", "C0018784#ent", "<e2>", "SNHL", ")", "and", "vestibulopathy", "."], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [12, 13]}}
{"token": ["Nine", "patients", "who", "fell", "C0231218#ent", "<e1>", "with", "a", "classical", "or", "unequivocal", "rheumatoid", "arthritis", "treated", "with", "mg", "C0733383#ent", "<e2>", "a", "week", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0733383", "name": "C0733383#ent", "pos": [16, 17]}}
{"token": ["Sj\u00f6gren's", "syndrome", "SS", ")", "is", "a", "C0004364#ent", "<e1>", "mainly", "affects", "the", "exocrine", "glands", "usually", "presents", "with", "C0086981#ent", "<e2>", "symptoms", "of", "the", "main", "mucosal", "surfaces", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0086981", "name": "C0086981#ent", "pos": [16, 17]}}
{"token": ["C0008683#ent", "<e1>", "functional", "endoscopic", "sinus", "surgery", "represent", "persistent", ",", "recurrent", ",", "or", "C0271725#ent", "<e2>"], "h": {"id": "C0008683", "name": "C0008683#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271725", "name": "C0271725#ent", "pos": [12, 13]}}
{"token": ["Syndrome", "C1698581#ent", "<e1>", "is", "the", "most", "frequent", "cause", "of", "C0232939#ent", "<e2>", "90", "%", ")", "."], "h": {"id": "C1698581", "name": "C1698581#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0232939", "name": "C0232939#ent", "pos": [9, 10]}}
{"token": ["Mayer-Rokitansky-K\u00fcster-Hauser", "syndrome", "C1698581#ent", "<e1>", ")", "is", "the", "second", "most", "common", "cause", "of", "C0232939#ent", "<e2>", "a", "reported", "incidence", "of", "1:4000", "."], "h": {"id": "C1698581", "name": "C1698581#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0232939", "name": "C0232939#ent", "pos": [12, 13]}}
{"token": ["The", "first", "response", "is", "a", "Helicobacter-independent", "response", ",", "present", "in", "all", "experimental", "groups", "which", "is", "directed", "toward", "C0796126#ent", "<e1>", "such", "as", "C0041945#ent", "<e2>", "and", "heat", "shock", "proteins"], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0041945", "name": "C0041945#ent", "pos": [21, 22]}}
{"token": ["The", "C1367472#ent", "<e1>", "production", "by", "AM", "was", "significantly", "suppressed", "by", "PGE2", "and", "C0009262#ent", "<e2>", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [12, 13]}}
{"token": ["Preincubation", "of", "the", "cytotoxic", "lymphocytes", "\"", "cold-insoluble", "globulin\"", "C1367472#ent", "<e1>", ")", "protected", "the", "cells", "from", "ATP", "and", "C0009262#ent", "<e2>", "inhibition", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [17, 18]}}
{"token": ["Preincubation", "of", "the", "cytotoxic", "lymphocytes", "\"", "C1367472#ent", "<e1>", "CIg", ")", "protected", "the", "cells", "from", "ATP", "and", "C0009262#ent", "<e2>", "inhibition", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [16, 17]}}
{"token": ["C0004057#ent", "<e1>", "is", "showing", "potential", "in", "reducing", "the", "risk", "of", "several", "C0029896#ent", "<e2>", "of", "public", "health", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "indicate", "that", "NO2-induced", "increases", "in", "pulmonary", "C0633225#ent", "<e1>", "also", "reflected", "in", "isolated", "C3813124#ent", "<e2>", "and", "type", "II", "cells"], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [14, 15]}}
{"token": ["These", "values", ",", "as", "well", "as", "total", "muscle", "protein", "content", ",", "in", "the", "group", "with", "C0010583#ent", "<e1>", "injection", "plus", "C0282193#ent", "<e2>", "were", "larger", "than", "in", "the", "group", "with", "C0010583#ent", "<e1>", "injection", "alone", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0282193", "name": "C0282193#ent", "pos": [19, 20]}}
{"token": ["In", "patients", "with", "congestive", "heart", "failure", "C0019099#ent", "<e1>", ")", ",", "continuous", "diuretic", "therapy", "may", "result", "in", "C0022660#ent", "<e2>", "ARI", ")", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [16, 17]}}
{"token": ["Profound", "reduction", "of", "cardiac", "output", "arterial", "hypotension", "severe", "C0019099#ent", "<e1>", "may", "lead", "to", "C0022660#ent", "<e2>"], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [13, 14]}}
{"token": ["Thymidine", "kinase", "a", "key", "C0014442#ent", "<e1>", "responsible", "for", "the", "activation", "of", "several", "anticancer", "and", "C0013227#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [14, 15]}}
{"token": ["Genotypes", "of", "DNA", "repair", "genes", "XRCC1", ",", "C1335081#ent", "<e1>", ",", "PARP", ",", "XPD", ",", "XRCC3", "and", "C1337033#ent", "<e2>", ")", "were", "analyzed", "by", "PCR-RFLP", "assays", "."], "h": {"id": "C1335081", "name": "C1335081#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337033", "name": "C1337033#ent", "pos": [16, 17]}}
{"token": ["The", "PP2C", "phosphatase", "C2981728#ent", "<e1>", "dephosphorylates", "p38", "and", "blocks", "UV-induced", "C1705526#ent", "<e2>", "activation", "in", "cultured", "human", "cells"], "h": {"id": "C2981728", "name": "C2981728#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [10, 11]}}
{"token": ["In", "one", "patient", "C0376261#ent", "<e1>", "could", "be", "observed", "8", "weeks", "after", "a", "transient", "C0745413#ent", "<e2>"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0745413", "name": "C0745413#ent", "pos": [13, 14]}}
{"token": ["A", "protein", "which", "reacts", "with", "the", "C0032594#ent", "<e1>", "of", "Streptococcus", "pneumoniae", "is", "inhibited", "by", "C0311989#ent", "<e2>", "was", "isolated", "from", "the", "serum", "of", "rainbow", "trout", "affinity", "chromatography"], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0311989", "name": "C0311989#ent", "pos": [14, 15]}}
{"token": ["Their", "cytoplasmic", "membrane", "not", "sufficiently", "disrupted", "by", "the", "C0030956#ent", "<e1>", "to", "promote", "C3272349#ent", "<e2>", "resulting", "in", "unhindered", "growth", "of", "these", "mutants", "in", "the", "presence", "of", "high", "doses", "200", "AU/ml", ")", "of", "Pep", "5"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3272349", "name": "C3272349#ent", "pos": [12, 13]}}
{"token": ["GH", "treatment", "increased", "the", "occupancy", "of", "both", "endogenous", "C1530423#ent", "<e1>", "and", "phospho-C/EBPbeta", "on", "the", "C0087140#ent", "<e2>", "promoter", "."], "h": {"id": "C1530423", "name": "C1530423#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [14, 15]}}
{"token": ["Notably", ",", "the", "CRE-protein", "complexes", "were", "supershifted", "by", "C1530423#ent", "<e1>", "antibody", ",", "and", "CREB", ",", "C0087140#ent", "<e2>", ",", "c-Jun", ",", "and", "AR", "antibodies", "disrupted", "the", "complexes", "formation", "."], "h": {"id": "C1530423", "name": "C1530423#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [15, 16]}}
{"token": ["Fibre", "C1423506#ent", "<e1>", "and", "networks", "provide", "flexibility", "and", "C0427008#ent", "<e2>", "to", "the", "weak", "pneu-", "or", "hydroskeleton", "."], "h": {"id": "C1423506", "name": "C1423506#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0427008", "name": "C0427008#ent", "pos": [8, 9]}}
{"token": ["A", "limited", "number", "of", "studies", "reveal", "an", "association", "between", "C0314719#ent", "<e1>", "and", "significant", "systemic", "diseases", "protein-energy", "malnutrition", "diarrhoea", ",", "and", "C0339901#ent", "<e2>"], "h": {"id": "C0314719", "name": "C0314719#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0339901", "name": "C0339901#ent", "pos": [20, 21]}}
{"token": ["We", "now", "show", "that", "C1416797#ent", "<e1>", "the", "SMN1", "gene", "product", "interacts", "directly", "with", "the", "C0079427#ent", "<e2>", "p53", "."], "h": {"id": "C1416797", "name": "C1416797#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [14, 15]}}
{"token": ["There", "was", "no", "apparent", "effect", "of", "C1367721#ent", "<e1>", "on", "the", "expression", "of", "C0042071#ent", "<e2>", "72-kDa", "type-IV", "collagenase", "IMC-2", "cells", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [12, 13]}}
{"token": ["C0003615#ent", "<e1>", "is", "a", "common", "C0012634#ent", "<e2>", "often", "presents", "with", "vague", ",", "inconclusive", "symptoms", "."], "h": {"id": "C0003615", "name": "C0003615#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [5, 6]}}
{"token": ["C0003615#ent", "<e1>", "and", "diverticulitis", "are", "examples", "of", "such", "C0012634#ent", "<e2>", ",", "and", "this", "article", "reviews", "the", "current", "role", "of", "CT", "scans", "the", "diagnosis", "and", "management", "of", "patients", "with", "these", "conditions", "."], "h": {"id": "C0003615", "name": "C0003615#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}}
{"token": ["This", "paper", "reports", "C0026896#ent", "<e1>", "a", "7-year-old", "boy", "with", "predominant", "facial", "muscle", "weakness", "ophthalmoplegia", "and", "C0005745#ent", "<e2>", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [15, 16]}}
{"token": ["The", "inferred", "amino", "acid", "sequence", "C0036843#ent", "<e1>", "not", "significantly", "homologous", "to", "that", "of", "other", "known", "C0086376#ent", "<e2>", "of", "similar", "activity", "."], "h": {"id": "C0036843", "name": "C0036843#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["Tremors", "and", "C1413357#ent", "<e1>", "can", "be", "attributed", "to", "C3831153#ent", "<e2>", "."], "h": {"id": "C1413357", "name": "C1413357#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [8, 9]}}
{"token": ["Genes", "encoding", "C0086376#ent", "<e1>", "involved", "in", "molecular", "mimicry", "bacterium", "and", "gastric", "epithelial", "tissue", "specifically", "those", "encoding", "C1429589#ent", "<e2>", "Lewis", "Y", "antigens", "are", "discussed", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1429589", "name": "C1429589#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "C0002421#ent", "<e1>", "significantly", "increased", "the", "C0026703#ent", "<e2>", "PAS-positive", "substance", "in", "the", "guinea", "pig", "tracheal", "submucosal", "glands"], "h": {"id": "C0002421", "name": "C0002421#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026703", "name": "C0026703#ent", "pos": [7, 8]}}
{"token": ["A", "VDR", "ablated", "transgenic", "animal", "model", "VDDRII", ",", "C3536983#ent", "<e1>", "has", "been", "developed", "and", "the", "animals", "typically", "have", "various", "C0012634#ent", "<e2>", "including", ",", "hypocalcemia", ",", "hyperparathyroidism", ",", "rickets", ",", "osteomalacia", ",", "and", "alopecia", "."], "h": {"id": "C3536983", "name": "C3536983#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [19, 20]}}
{"token": ["Acrivastine", "was", "more", "effective", "than", "placebo", "and", "similar", "in", "efficacy", "to", "C0008929#ent", "<e1>", "or", "terfenadine", "in", "the", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C0008929", "name": "C0008929#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [19, 20]}}
{"token": ["Due", "to", "C0030293#ent", "<e1>", "patients", "with", "C0010674#ent", "<e2>", "mucosa", "of", "the", "bowel", "may", "have", "more", "contact", "with", "the", "complete", "gluten", "protein"], "h": {"id": "C0030293", "name": "C0030293#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [6, 7]}}
{"token": ["Pancreatic", "enzyme", "replacement", "the", "cornerstone", "of", "treating", "C0030293#ent", "<e1>", "patients", "with", "C0010674#ent", "<e2>"], "h": {"id": "C0030293", "name": "C0030293#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [11, 12]}}
{"token": ["Point", "mutations", "peripheral", "myelin", "gene", "22", "PMP22", ")", ",", "myelin", "protein", "zero", "MPZ", ")", ",", "and", "C1415076#ent", "<e1>", "Cx32", ")", "have", "been", "reported", "in", "C0270911#ent", "<e2>", ",", "and", "in", "PMP22", "in", "HNPP", "patients", "without", "deletion", "."], "h": {"id": "C1415076", "name": "C1415076#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [24, 25]}}
{"token": ["This", "enzyme", ",", "which", "catabolizes", "the", "neuropeptide", "N-acetylaspartylglutamate", "has", "also", "been", "known", "as", "N-acetylated", "alpha-linked", "acidic", "dipeptidase", "C0067685#ent", "<e1>", ")", ",", "and", "is", "identical", "to", "the", "C1333570#ent", "<e2>", "to", "the", "jejunal", "folylpoly-gamma-glutamate", "carboxypeptidase"], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [26, 27]}}
{"token": ["Prostate", "specific", "membrane", "antigen", "C0067685#ent", "<e1>", ")", ",", "also", "known", "as", "folate", "hydrolase", "C1333570#ent", "<e2>", ")", ",", "is", "a", "100", "kDa", "glycoprotein", "with", "elevated", "expression", "in", "prostate", "epithelial", "tissue", "."], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [13, 14]}}
{"token": ["Prostate", "specific", "membrane", "antigen", "C0067685#ent", "<e1>", ")", ",", "also", "known", "as", "C1333570#ent", "<e2>", "FOLH1", ")", ",", "is", "a", "100", "kDa", "glycoprotein", "with", "elevated", "expression", "in", "prostate", "epithelial", "tissue", "."], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [11, 12]}}
{"token": ["An", "C0014863#ent", "<e1>", "be", "treated", "with", "anticholinergic", "agent", "nitro-glycerinlike", "product", ",", "or", "C0020592#ent", "<e2>"], "h": {"id": "C0014863", "name": "C0014863#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [12, 13]}}
{"token": ["Analysis", "of", "the", "completed", "archaeal", "genomes", "that", "all", "archaea", "that", "possess", "C1384524#ent", "<e1>", "AsnRS", ")", "also", "display", "a", "second", "C0013570#ent", "<e2>", "encoding", "an", "AsnRS", "truncated", "from", "its", "anticodon", "binding-domain", "(", "AsnRS2", ")", "."], "h": {"id": "C1384524", "name": "C1384524#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [19, 20]}}
{"token": ["The", "type", "of", "C0393593#ent", "<e1>", "was", "found", "to", "be", "tonic", ",", "phasic", "or", "C0423320#ent", "<e2>", "."], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0423320", "name": "C0423320#ent", "pos": [13, 14]}}
{"token": ["Anemia", "is", "often", "observed", "in", "C0017178#ent", "<e1>", "as", "gastroduodenal", "ulcers", "esophageal", "varices", "atrophic", "gastritis", "malignant", "neoplasms", "inflammatory", "bowel", "diseases", "gastrectomy", ",", "C0024523#ent", "<e2>", "and", "liver", "diseases"], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [21, 22]}}
{"token": ["Above", "study", "has", "further", "shown", "that", "there", "is", "a", "strong", "hydrogen", "bonding", "interaction", "between", "the", "C0032483#ent", "<e1>", "groups", "of", "non-ionic", "micelles", "and", "the", "C1425386#ent", "<e2>", "of", "2-APBI", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1425386", "name": "C1425386#ent", "pos": [23, 24]}}
{"token": ["In", "essence", "the", "background", "C0009090#ent", "<e1>", "evaluation", "problem", "for", "C1332120#ent", "<e2>", "is", "consistent", "with", "deterministic", "parameter", "estimation", "problem", "."], "h": {"id": "C0009090", "name": "C0009090#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332120", "name": "C1332120#ent", "pos": [9, 10]}}
{"token": ["This", "is", "a", "performance", "evaluation", "on", "the", "implementation", "of", "the", "Cramer-Rao", "lower", "bound", "(", "CRLB", ")", "for", "background", "C0009090#ent", "<e1>", "measurement", "on", "automatic", "target", "recognition", "C1332120#ent", "<e2>", ")", "."], "h": {"id": "C0009090", "name": "C0009090#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332120", "name": "C1332120#ent", "pos": [25, 26]}}
{"token": ["This", "negative", "effect", "partially", "prevented", "by", "superoxide", "dismutase", "C0007367#ent", "<e1>", "and", "by", "C0599532#ent", "<e2>", "protecting", "agents", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [12, 13]}}
{"token": ["This", "UVC-induced", "PLD", "activity", "was", "found", "to", "be", "dependent", "on", "the", "presence", "of", "extracellular", "calcium", "and", "was", "inhibited", "by", "C0007367#ent", "<e1>", "as", "well", "as", "amifostine-an", "intracellular", "C0599532#ent", "<e2>", "antioxidant", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [26, 27]}}
{"token": ["Here", "we", "showed", "that", "treatment", "of", "zebrafish", "expressing", "a", "truncated", "form", "of", "Apc", "with", "either", "retinoic", "acid", "a", "selective", "C1705323#ent", "<e1>", "inhibitor", "decreased", "beta-catenin", "protein", "levels", "C1332447#ent", "<e2>"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [26, 27]}}
{"token": ["We", "have", "previously", "presented", "genetic", "evidence", "the", "possible", "involvement", "of", "alcohol", "and", "aldehyde", "dehydrogenases", "ADH", ";", "ALDH", ")", "by", "identifying", "genetic", "variants", "C1312457#ent", "<e1>", "and", "ADH4", "that", "associate", "with", "C3160718#ent", "<e2>", "."], "h": {"id": "C1312457", "name": "C1312457#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [29, 30]}}
{"token": ["Controls", ",", "aged", "40", "years", "or", "over", ",", "were", "55", "hospitalized", "patients", "diagnosed", "as", "having", "C0740766#ent", "<e1>", "four", "outpatients", "with", "common", "C0009443#ent", "<e2>", "."], "h": {"id": "C0740766", "name": "C0740766#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "with", "the", "use", "of", "2", "different", "antisera", "directed", "against", "human", "C1367551#ent", "<e1>", "we", "present", "evidence", "for", "immunochemical", "heterogeneity", "this", "hormone", "in", "C0030305#ent", "<e2>"], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [23, 24]}}
{"token": ["The", "role", "of", "C1367551#ent", "<e1>", "as", "a", "secretory", "inhibition", "agent", "the", "treatment", "of", "C0030305#ent", "<e2>", "studied", "by", "a", "randomized", "and", "prospective", "procedure"], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [13, 14]}}
{"token": ["Recently", "in", "our", "laboratory", "we", "have", "demonstrated", "increased", "immunoreactive", "C1367551#ent", "<e1>", "(", "iCT", ")", "levels", "in", "4", "patients", "with", "C0030305#ent", "<e2>", "hypocalcemia", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [19, 20]}}
{"token": ["Our", "pilot", "study", "to", "determine", "the", "effect", "of", "tumor", "necrosis", "factor-alpha", "C0812246#ent", "<e1>", ")", "308", "G-->A", "promoter", "single-nucleotide", "polymorphism", "in", "pediatric", "C0010346#ent", "<e2>", "IBD", ")", ",", "its", "influence", "on", "inflammatory", "activity", "the", "clinical", "manifestations"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [21, 22]}}
{"token": ["C0812246#ent", "<e1>", "concentration", "was", "increased", "significantly", "when", "DC", "from", "C0010346#ent", "<e2>", "stimulated", "with", "HSP70", "or", "CD40L", "and", "this", "was", "associated", "with", "signalling", "by", "the", "extracellular", "signal", "regulated", "kinase", "ERK", ")", "1/2", "and", "p38", "mitogen", "activated", "protein", "MAP", ")", "kinase", "pathway"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [9, 10]}}
{"token": ["There", "was", "a", "significant", "reduction", "in", "lipopolysaccharide", "stimulated", "C0812246#ent", "<e1>", "alpha", "generation", "in", "ulcerative", "colitis", "patients", "compared", "with", "C0010346#ent", "<e2>", "normal", "control", "subjects", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [18, 19]}}
{"token": ["The", "phospholipid", "organization", "unilamellar", "vesicles", "of", "various", "purified", "phospholipid", "components", "monkey", "C1420193#ent", "<e1>", "ascertained", "using", "C3539768#ent", "<e2>", "trinitrobenzenesulfonic", "acid", "external", "membrane", "probes"], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "C1426200#ent", "<e1>", "could", "activate", "p38", "MAPK", "C0082529#ent", "<e2>", "ERK", ")", "and", "c-Jun", "N-terminal", "kinase", "JNK", ")", "of", "BEAS-2B", "cells", "."], "h": {"id": "C1426200", "name": "C1426200#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [9, 10]}}
{"token": ["The", "major", "cytosolic", "substrate", "of", "the", "insulin", "receptor", "a", "185-kDa", "phosphoprotein", "(", "C1334140#ent", "<e1>", ")", "that", "contains", "multiple", "putative", "attachment", "for", "the", "p85", "alpha", "regulatory", "subunit", "phosphatidylinositol", "3'-kinase", "C1709402#ent", "<e2>", "."], "h": {"id": "C1334140", "name": "C1334140#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [28, 29]}}
{"token": ["The", "greater", "trochanteric", "pain", "syndrome", "(", "GTPS", ")", "or", "trochanteric", "bursitis", "a", "C0850603#ent", "<e1>", "by", "typical", "C0234233#ent", "<e2>", "the", "trochanteric", "region"], "h": {"id": "C0850603", "name": "C0850603#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0234233", "name": "C0234233#ent", "pos": [16, 17]}}
{"token": ["C0020179#ent", "<e1>", "differently", "from", "adult", "C0020179#ent", "<e1>", "has", "more", "variability", "in", "presentation", "."], "h": {"id": "C0020179", "name": "C0020179#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020179", "name": "C0020179#ent", "pos": [0, 1]}}
{"token": ["In", "contrast", "to", "its", "effects", "on", "normal", "endothelial", "and", "aortic", "smooth", "muscle", "cell", "cultures", "C0069535#ent", "<e1>", "a", "potent", "C0026249#ent", "<e2>", "for", "cells", "derived", "from", "acquired", "immunodeficiency", "syndrome-related", "Kaposi's", "sarcoma", "AIDS-KS", ")", "."], "h": {"id": "C0069535", "name": "C0069535#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [18, 19]}}
{"token": ["Similarities", "in", "the", "sequence", "around", "the", "\"", "essential", "\"", "cysteine", "residue", "lactate", "dehydrogenase", "C3536868#ent", "<e1>", "and", "yeast", "and", "C0001942#ent", "<e2>", "delineated", "."], "h": {"id": "C3536868", "name": "C3536868#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [18, 19]}}
{"token": ["The", "oxidative", "stress", "used", "to", "induce", "S-thiolation", "are", "shown", "to", "inhibit", "GAPDH", "(", "C3536868#ent", "<e1>", ",", "enolase", "and", "C0001942#ent", "<e2>", "activities", ",", "whereas", "they", "have", "no", "effect", "aldolase", ",", "triose", "phosphate", "isomerase", "aldehyde", "dehydrogenase", "activities", "."], "h": {"id": "C3536868", "name": "C3536868#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "these", "data", "are", "strengthened", "by", "in", "vitro", "studies", "showing", "that", "inhibition", "of", "EGFR", ",", "RAS", ",", "C1709402#ent", "<e1>", "and", "AKT", "C0034541#ent", "<e2>", "cell", "lines"], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0034541", "name": "C0034541#ent", "pos": [22, 23]}}
{"token": ["Inhibition", "of", "the", "RhoA-associated", "kinase", "overexpression", "of", "dominant", "negative", "C0084340#ent", "<e1>", "reduced", "the", "stimulated", "C1413791#ent", "<e2>", "expression", "indicative", "of", "a", "role", "for", "C0084340#ent", "<e1>", "signaling", "in", "C1413791#ent", "<e2>", "expression", "."], "h": {"id": "C1413791", "name": "C1413791#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [9, 10]}}
{"token": ["Pigs", "were", "bred", "to", "exhibit", "one", "of", "the", "three", "HAL", "genotypes", "(", "NN", ",", "Nn", ",", "and", "C4284038#ent", "<e1>", ")", "with", "otherwise", "equivalent", "C0017428#ent", "<e2>", "."], "h": {"id": "C4284038", "name": "C4284038#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [23, 24]}}
{"token": ["C1420102#ent", "<e1>", "in", "children", "is", "usually", "a", "part", "of", "the", "multiple", "endocrine", "neoplasia", "MEN", ")", "syndrome", "(", "C1420102#ent", "<e1>", ",", "pheochromocytoma", ",", "and", "C1840402#ent", "<e1>", ")", "and", "is", "detected", "by", "screening", "studies"], "h": {"id": "C1420102", "name": "C1420102#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [23, 24]}}
{"token": ["The", "enzyme", "active", "site", "considerable", "similarity", "to", "that", "of", "dimethyl", "sulfoxide", "DMSO", ")", "C0030016#ent", "<e1>", ",", "in", "that", ",", "like", "C0058232#ent", "<e2>", "the", "TMAO", "reductase", "active", "site", "exist", "in", "multiple", "forms"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0058232", "name": "C0058232#ent", "pos": [20, 21]}}
{"token": ["C0003158#ent", "<e1>", "not", "metabolized", "to", "C1260386#ent", "<e2>", "conjugates", "in", "the", "helminths", "studied", "and", "did", "not", "inhibit", "GSH-S-aryltransferase", "activity", "towards", "chlorodinitrobenzene", "."], "h": {"id": "C0003158", "name": "C0003158#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [5, 6]}}
{"token": ["In", "humans", ",", "loss-of-function", "mutations", "in", "the", "SLC25A13", "gene", "encoding", "citrin", "cause", "both", "adult-onset", "type", "II", "citrullinemia", "neonatal", "C0268312#ent", "<e1>", "collectively", "referred", "to", "as", "human", "C1997910#ent", "<e2>"], "h": {"id": "C0268312", "name": "C0268312#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1997910", "name": "C1997910#ent", "pos": [25, 26]}}
{"token": ["C1420492#ent", "<e1>", "analysis", "further", "showed", "that", "DNMT1", "and", "C1333891#ent", "<e2>", "binding", "to", "the", "MGMT", "promoter", "was", "increased", "by", "MGMT", "promoter", "methylation", "and", "decreased", "by", "MGMT", "promoter", "demethylation"], "h": {"id": "C1420492", "name": "C1420492#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [8, 9]}}
{"token": ["Recent", "clinical", "experience", "with", "C0040517#ent", "<e1>", "TS", ")", "patients", "suggests", "that", "the", "nicotinic", "receptor", "antagonist", "C0025029#ent", "<e2>", "(", "Inversine", ")", ",", "may", "be", "a", "useful", "adjunct", "to", "neuroleptic", "therapy", "controlling", "tic", "symptom", "."], "h": {"id": "C0040517", "name": "C0040517#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0025029", "name": "C0025029#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "in", "adolescents", "and", "young", "adults", "C0011847#ent", "<e1>", ",", "rhIGF-I", "administration", "directly", "affected", "insulin", "requirements", "independent", "of", "C3539616#ent", "<e2>", "levels", ",", "but", "had", "no", "effect", "on", "fatty", "acid", "ketone", "levels"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [19, 20]}}
{"token": ["C0026821#ent", "<e1>", "often", "associated", "with", "lower", "motoneuron", "disorders", "but", "features", "of", "cramps", "in", "C0024408#ent", "<e2>", "patients", "have", "never", "been", "studied", "."], "h": {"id": "C0026821", "name": "C0026821#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0024408", "name": "C0024408#ent", "pos": [13, 14]}}
{"token": ["Cilostazol", "(", "6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-", "qui", "nolinone", ",", "C0133983#ent", "<e1>", ")", ",", "a", "new", "C0016018#ent", "<e2>", "has", "a", "potent", "inhibitory", "action", "on", "platelet", "aggregation"], "h": {"id": "C0133983", "name": "C0133983#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "C2986464#ent", "<e1>", "functions", "as", "a", "physiological", "partner", "inhibitor", "of", "C1307220#ent", "<e2>", ",", "which", "provides", "an", "example", "of", "how", "a", "transcription", "factor", "regulates", "upstream", "signaling", "events", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1307220", "name": "C1307220#ent", "pos": [11, 12]}}
{"token": ["However", ",", "how", "C2986464#ent", "<e1>", "inhibits", "the", "signaling", "function", "C1307220#ent", "<e2>", "is", "not", "completely", "understood", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1307220", "name": "C1307220#ent", "pos": [9, 10]}}
{"token": ["This", "interaction", "takes", "place", "via", "the", "phosphorylated", "YMXM", "motifs", "of", "C1704984#ent", "<e1>", "and", "the", "Src", "homology", "region", "2", "SH2", ")", "domains", "of", "C1423078#ent", "<e2>", "."], "h": {"id": "C1704984", "name": "C1704984#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1423078", "name": "C1423078#ent", "pos": [22, 23]}}
{"token": ["Binding", "experiments", "with", "various", "SH2", "protein", "that", "Grb-2", "was", "largely", "excluded", "from", "C1704984#ent", "<e1>", "complexes", "containing", "p59fyn", ",", "whereas", "Grb-2", "and", "C1423078#ent", "<e2>", "occurred", "in", "the", "same", "Irs-1", "complex", "."], "h": {"id": "C1704984", "name": "C1704984#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423078", "name": "C1423078#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "other", "C0031727#ent", "<e1>", "reported", "to", "have", "anti-apoptotic", "properties", ",", "such", "as", "C0139905#ent", "<e2>", "and", "Akt", ",", "are", "inactivated", "by", "proteolytic", "degradation", "the", "caspase", "system"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [14, 15]}}
{"token": ["Receptor", "tyrosine", "kinases", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e1>", "through", "Ras", ",", "C0139905#ent", "<e2>", ",", "and", "MEK", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [12, 13]}}
{"token": ["p38", "also", "forms", "a", "complex", "with", "the", "C1307053#ent", "<e1>", "stimulated", "cells", "and", "is", "a", "substrate", "for", "the", "C0031727#ent", "<e2>", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["The", "results", "suggest", "that", "C1307053#ent", "<e1>", ",", "autophosphorylation", ",", "and", "phosphorylation", "by", "C0031727#ent", "<e2>", "other", "than", "C1307053#ent", "<e1>", ",", "may", "all", "contribution", "to", "repressing", "Src", "catalytic", "activity", "in", "fibroblasts", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}}
{"token": ["In", "T24", "cells", "the", "C0014442#ent", "<e1>", "resembled", "the", "C0002059#ent", "<e2>", "electrophoretic", "mobility", "sensitivity", "to", "heat", "denaturation"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002059", "name": "C0002059#ent", "pos": [8, 9]}}
{"token": ["The", "C0014442#ent", "<e1>", "had", "a", "broad", "specificity", "against", "C0002059#ent", "<e2>", "and", "also", "attacked", "some", "acid", "anhydrides"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002059", "name": "C0002059#ent", "pos": [8, 9]}}
{"token": ["Human", "patients", "carrying", "loss-of-function", "mutations", "in", "the", "genes", "encoding", "the", "C0599220#ent", "<e1>", "of", "3-methylcrotonyl-CoA", "carboxylase", "from", "C0268600#ent", "<e2>", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268600", "name": "C0268600#ent", "pos": [16, 17]}}
{"token": ["The", "most", "frequent", "are", "icterical", ",", "gastroenterocolitical", ",", "C0015230#ent", "<e1>", "and", "meningeal", "syndromes", "then", "follow", "C0858195#ent", "<e2>", "anginas", ",", "status", "febrilis", "and", "pertussis", "syndrome"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0858195", "name": "C0858195#ent", "pos": [15, 16]}}
{"token": ["C1836330#ent", "<e1>", "is", "also", "characterized", "by", "C0020757#ent", "<e2>", ",", "sensorineural", "hearing", "loss", "peripheral", "neuropathy", "psychomotor", "retardation", "congenital", "chronic", "diarrhea", "and", "an", "elevation", "of", "very", "long", "chain", "fatty", "acids", "(", "VLCFAs", ")", "."], "h": {"id": "C1836330", "name": "C1836330#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020757", "name": "C0020757#ent", "pos": [6, 7]}}
{"token": ["Mechanistically", ",", "polyphyllin", "D", "dissipates", "the", "mitochondrial", "membrane", "potential", "induces", "a", "downregulation", "of", "anti-apoptotic", "Bcl-2", "expression", "and", "an", "up-regulation", "of", "C1335191#ent", "<e1>", "Bax", "expression", ",", "and", "activates", "C1705066#ent", "<e2>", "."], "h": {"id": "C1335191", "name": "C1335191#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1705066", "name": "C1705066#ent", "pos": [27, 28]}}
{"token": ["In", "chromatin", "immunoprecipitation", "studies", "rifampicin", "treatment", "did", "not", "inhibit", "HNF-4", "binding", "to", "the", "native", "promoters", "of", "CYP7A1", "and", "C0038315#ent", "<e1>", "but", "resulted", "in", "dissociation", "of", "C4054191#ent", "<e2>", "and", "concomitant", "gene", "repression"], "h": {"id": "C0038315", "name": "C0038315#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4054191", "name": "C4054191#ent", "pos": [25, 26]}}
{"token": ["Inherited", "mutations", "a", "purine", "salvage", "enzyme", "hypoxanthine", "guanine", "phosphoribosyltransferase", "HPRT", ",", "C0040083#ent", "<e1>", ",", "give", "rise", "to", "C0023374#ent", "<e2>", "HPRT-related", "gout", "."], "h": {"id": "C0040083", "name": "C0040083#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [17, 18]}}
{"token": ["C3490418#ent", "<e1>", "casein", "kinase", "2", "is", "a", "ubiquitous", "C0299851#ent", "<e2>", "in", "cell", "proliferation"], "h": {"id": "C3490418", "name": "C3490418#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0299851", "name": "C0299851#ent", "pos": [8, 9]}}
{"token": ["Expression", "of", "Oct-4", "in", "differentiated", "cells", "not", "sufficient", "to", "activate", "transcription", "from", "a", "distance", ",", "rather", "it", "requires", "the", "co-expression", "of", "C3275267#ent", "<e1>", "such", "as", "the", "adenoviral", "oncoprotein", "C1709313#ent", "<e2>", "."], "h": {"id": "C3275267", "name": "C3275267#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [28, 29]}}
{"token": ["Using", "the", "14", "C0017337#ent", "<e1>", ",", "a", "Principal", "Components", "Analysis", "well", "as", "a", "cluster", "analysis", "a", "C1420620#ent", "<e2>", "subgroup", "(", "n", "=", "10/16", ")", "that", "overexpressed", "the", "NK", "genes", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [16, 17]}}
{"token": ["This", "region", "was", "shown", "to", "interact", "with", "the", "FG-repeat", "domains", "of", "nucleoporins", "Nup98", "Nup153", ",", "and", "C1704852#ent", "<e1>", ",", "indicating", "that", "the", "C1424873#ent", "<e2>", "association", "occurs", "through", "components", "of", "the", "nuclear", "pore", "complex"], "h": {"id": "C1704852", "name": "C1704852#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1424873", "name": "C1424873#ent", "pos": [22, 23]}}
{"token": ["EC50", "values", "for", "C0753970#ent", "<e1>", "translocation", "by", "C1537501#ent", "<e2>", "or", "kallidin", "were", "2", "and", "0.6", "nM", "respectively", "."], "h": {"id": "C0753970", "name": "C0753970#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [7, 8]}}
{"token": ["The", "investigative", "regimen", "B", ")", "included", "simultaneous", "administration", "of", "C1161438#ent", "<e1>", "+", "C0023972#ent", "<e2>", "alternating", "with", "C1161438#ent", "<e1>", "+", "doxorubicin", ",", "and", "with", "doxorubicin", "+", "C0023972#ent", "<e2>", "."], "h": {"id": "C0023972", "name": "C0023972#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [9, 10]}}
{"token": ["By", "centrifugal", "elutriation", "viable", "cell", "subpopulations", "isolated", "directly", "from", "KHT", "sarcomas", "treated", "with", "C0023972#ent", "<e1>", ",", "mitomycin", "(", "MIT", "C", ")", ",", "C1161438#ent", "<e2>", "(", "CTX", ")", ",", "or", "radiation", "."], "h": {"id": "C0023972", "name": "C0023972#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [22, 23]}}
{"token": ["In", "all", "patients", "with", "gastrinoma", "(", "both", "C0030304#ent", "<e1>", "and", "duodenal", ")", "C1333714#ent", "<e2>", "augmented", "serum", "gastrin", "."], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [12, 13]}}
{"token": ["The", "present", "study", "indicates", "that", "the", "C0030304#ent", "<e1>", "system", "may", "be", "regulated", "by", "C1333714#ent", "<e2>", "in", "vivo"], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [13, 14]}}
{"token": ["Rab5a", "is", "efficiently", "phosphorylated", "by", "extracellular-regulated", "kinase", "1", "not", "by", "C0170168#ent", "<e1>", "while", "cdc2", "kinase", "phosphorylates", "Ser-123", "of", "C1419213#ent", "<e2>", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419213", "name": "C1419213#ent", "pos": [18, 19]}}
{"token": ["A", "80", "KD", "polypeptide", "C0029282#ent", "<e1>", "comigrated", "with", "the", "C1305923#ent", "<e2>", "of", "cytosol", "which", "was", "phosphorylated", "by", "polyamine-dependent", "protein", "kinase", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [9, 10]}}
{"token": ["Quantitative", "analyses", "based", "on", "the", "production", "of", "C0056650#ent", "<e1>", ",", "the", "formation", "of", "an", "adduct", "with", "C3541860#ent", "<e2>", ",", "and", "on", "absorbance", "at", "280", "nanometers", "."], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541860", "name": "C3541860#ent", "pos": [16, 17]}}
{"token": ["Five", "of", "13", "tumors", "tested", "contained", "C3641847#ent", "<e1>", "EBNA", ")", "and", "nine", "of", "11", "contained", "EBV", "C0017428#ent", "<e2>", "detected", "by", "DNA-DNA", "hybridization", "BamHI", "K", ",", "BamHI", "W", ",", "or", "EcoRI", "B", "cloned", "probes"], "h": {"id": "C3641847", "name": "C3641847#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [16, 17]}}
{"token": ["General", "sexual", "functioning", "decreased", "with", "age", "and", "was", "most", "apparent", "in", "patients", "with", "diabetes", "and", "C0002962#ent", "<e1>", "while", "glaucoma", "patients", "reported", "better", "results", "than", "the", "C4255078#ent", "<e2>", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4255078", "name": "C4255078#ent", "pos": [25, 26]}}
{"token": ["This", "study", "compares", "the", "health-related", "quality", "of", "life", "HRQOL", ")", "of", "patients", "with", "type", "2", "diabetes", "mellitus", "C0002962#ent", "<e1>", "that", "of", "a", "standard", "population", "sample", "C4255078#ent", "<e2>", ")", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4255078", "name": "C4255078#ent", "pos": [25, 26]}}
{"token": ["However", ",", "vasopressin", "binds", "to", "C1332123#ent", "<e1>", "enhances", "CRF", "induced", "C1704793#ent", "<e2>", "secretion", "."], "h": {"id": "C1332123", "name": "C1332123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [10, 11]}}
{"token": ["Ninety-two", "to", "94", "%", "of", "C0937846#ent", "<e1>", "40", "mg", "once", "daily", ")", "achieved", "healed", "C0014868#ent", "<e2>", "versus", "84", "to", "90", "%", "of", "omeprazole", "recipients", "(", "20", "mg", "once", "daily", ")", "."], "h": {"id": "C0937846", "name": "C0937846#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0014868", "name": "C0014868#ent", "pos": [14, 15]}}
{"token": ["Prevention", "of", "LV", "dilatation", "C0072973#ent", "<e1>", "was", "associated", "with", "decreased", "gelatinolytic", "activity", "and", "increased", "MMP-inhibition", "in", "C0018801#ent", "<e2>", "SHR", "."], "h": {"id": "C0072973", "name": "C0072973#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [16, 17]}}
{"token": ["Recombination", "among", "these", "mutations", "yielded", "C0007511#ent", "<e1>", "mutants", "that", "bypassed", "the", "C1413179#ent", "<e2>", "requirement", "."], "h": {"id": "C0007511", "name": "C0007511#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413179", "name": "C1413179#ent", "pos": [11, 12]}}
{"token": ["The", "C0127082#ent", "<e1>", "MMP", ")", "MMP-7", "(", "matrilysin", ")", "C0079429#ent", "<e2>", "is", "transcriptionally", "induced", "by", "signal", "transduction", "pathways", "from", "loss", "of", "APC", "function", "and", "contributes", "to", "the", "progression", "of", "benign", "and", "malignant", "intestinal", "epithelial", "cells"], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["The", "C0012544#ent", "<e1>", "investigated", "were", "zoledronate", ",", "risedronate", ",", "ibandronate", ",", "C0043603#ent", "<e2>", ",", "2-phenyl-1-hydroxyethane-1,1-bisphosphonate", ",", "and", "1-(2,2-bisphosphonoethyl)-3-iodo", "pyridinium", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0043603", "name": "C0043603#ent", "pos": [11, 12]}}
{"token": ["Non-N-containing", "members", "include", "etidronate", ",", "clodronate", "and", "tiludronate", ",", "while", "C0012544#ent", "<e1>", "active", "pharmaceutical", "compounds", "as", "C0043603#ent", "<e2>", ",", "neridronate", ",", "olpadronate", ",", "alendronate", ",", "ibandronate", ",", "risedronate", "and", "zoledronate", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [10, 11]}, "relation": "chemical_structure_of", "t": {"id": "C0043603", "name": "C0043603#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "a", "C1420871#ent", "<e1>", "encoding", "for", "the", "C3887669#ent", "<e2>", "Klebsiella", "pneumoniae", "was", "knocked", "out", "in", "an", "effort", "to", "metabolically", "engineer", "this", "strain", "as", "a", "model", "system", "the", "production", "of", "1,3-propanediol", "."], "h": {"id": "C1420871", "name": "C1420871#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [10, 11]}}
{"token": ["Escherichia", "coli", "cells", "a", "plasmid", "containing", "C1420871#ent", "<e1>", "had", "15-fold", "higher", "C3887669#ent", "<e2>", "activity", "than", "isogenic", "plasmid-free", "cells", ",", "confirming", "the", "identity", "of", "the", "cloned", "gene"], "h": {"id": "C1420871", "name": "C1420871#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [11, 12]}}
{"token": ["Increased", "levels", "of", "C0079068#ent", "<e1>", "elicited", "by", "C0812235#ent", "<e2>", "deletion", "increased", "the", "proliferation", "of", "nullizygous", "cells", ",", "whereas", "restoring", "C0812235#ent", "<e2>", "in", "null", "cells", "decreased", "the", "stability", "of", "C0079068#ent", "<e1>", "and", "restrained", "cell", "proliferation"], "h": {"id": "C0812235", "name": "C0812235#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [3, 4]}}
{"token": ["C0700450#ent", "<e1>", "infusion", "during", "dialysis", "significantly", "reduced", "the", "number", "of", "C0520541#ent", "<e2>", "increased", "left-ventricular", "ejection", "fraction", "and", "decreased", "the", "number", "of", "emergency", "admissions", "to", "the", "hospital", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0520541", "name": "C0520541#ent", "pos": [10, 11]}}
{"token": ["RNA", "hybridization", "analysis", "that", "C1414515#ent", "<e1>", "BLBP", ")", "and", "inhibitor", "of", "differentiation", "1", "Id1", ")", "C1417679#ent", "<e2>", "were", "among", "the", "five", "C1417679#ent", "<e2>", "that", "were", "rapidly", "and", "significantly", "up-regulated", "after", "induction", "of", "NDRF", "."], "h": {"id": "C1414515", "name": "C1414515#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "C0812215#ent", "<e1>", "activity", "was", "not", "significantly", "induced", "by", "C0078956#ent", "<e2>", "within", "5", "-", "15min", "."], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [11, 12]}}
{"token": ["NGF", "caused", "a", "limited", "increase", "in", "phosphorylation", "of", "C0812215#ent", "<e1>", "compared", "with", "C0078956#ent", "<e2>", ",", "and", "NGF-induced", "Raf", "activity", "independent", "of", "PKC", "."], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [12, 13]}}
{"token": ["The", "phosphorylation", "of", "MEK1/2", "and", "C0812215#ent", "<e1>", "induced", "by", "ET-1", "or", "C0078956#ent", "<e2>", "were", "also", "inhibited", "by", "EGCG", "."], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [11, 12]}}
{"token": ["In", "the", "setting", "of", "characteristic", "features", "of", "C0040156#ent", "<e1>", ",", "the", "timely", "diagnosis", "and", "aggressive", "management", "C0040127#ent", "<e2>", "result", "in", "a", "successful", "outcome", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040127", "name": "C0040127#ent", "pos": [16, 17]}}
{"token": ["Human", "Tf", "was", "found", "to", "be", "resolved", "in", "an", "uncoated", "capillary", "equilibrated", "with", "a", "C0991799#ent", "<e1>", "millimolar", "concentrations", "of", "C0112701#ent", "<e2>", "a", "buffer", "additive", "."], "h": {"id": "C0991799", "name": "C0991799#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0112701", "name": "C0112701#ent", "pos": [19, 20]}}
{"token": ["C0238339#ent", "<e1>", "did", "not", "increase", "TI", "in", "DT", "or", "C2348923#ent", "<e2>", "."], "h": {"id": "C0238339", "name": "C0238339#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2348923", "name": "C2348923#ent", "pos": [9, 10]}}
{"token": ["A", "young", "woman", "with", "recurrent", "thrombophlebitis", "splenectomy", "for", "C0398650#ent", "<e1>", "two", "cesarian", "sections", "found", "to", "carry", "a", "C0398625#ent", "<e2>"], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0398625", "name": "C0398625#ent", "pos": [17, 18]}}
{"token": ["The", "conformational", "change", "native", "C0008546#ent", "<e1>", "by", "poly(ADP-ribosyl)ation", "is", "reversible", "upon", "degradation", "of", "the", "histone", "H1-bound", "poly(ADP-ribose)", "C1418269#ent", "<e2>"], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418269", "name": "C1418269#ent", "pos": [17, 18]}}
{"token": ["The", "causal", "virus", ",", "which", "was", "isolated", "after", "it", "had", "been", "reactivated", "with", "C3536709#ent", "<e1>", ",", "had", "the", "DNA", "profile", "a", "bovine", "herpesvirus", "type", "1", "strain", "associated", "with", "clinically", "severe", "C0035204#ent", "<e2>"], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [30, 31]}}
{"token": ["The", "C1505379#ent", "<e1>", "PAK", ")", "family", "includes", "C0031727#ent", "<e2>", "by", "the", "GTPases", "rho", ",", "rac", ",", "and", "cdc42", "."], "h": {"id": "C1505379", "name": "C1505379#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}}
{"token": ["We", "report", "a", "child", "presenting", "with", "C1258215#ent", "<e1>", ",", "hypothermia", "and", "lethargy", "after", "receiving", "supratherapeutic", "dosing", "of", "C0031507#ent", "<e2>", "after", "a", "concentration", "miscalculation", "."], "h": {"id": "C1258215", "name": "C1258215#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [17, 18]}}
{"token": ["C0036075#ent", "<e1>", "and", "2,3-dihydroxybenzoate", "were", "both", "initially", "metabolized", "to", "give", "C0054858#ent", "<e2>", "."], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054858", "name": "C0054858#ent", "pos": [10, 11]}}
{"token": ["Attack", "by", ".OH", "radicals", ",", "generated", "by", "a", "Fenton", "system", ",", "upon", "C0036075#ent", "<e1>", "produces", "2,3-dihydroxybenzoate", "and", "2,5-dihydroxybenzoate", "as", "major", "products", "and", "C0054858#ent", "<e2>", "as", "a", "minor", "product", "."], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0054858", "name": "C0054858#ent", "pos": [22, 23]}}
{"token": ["Recruitment", "of", "C0104940#ent", "<e1>", "the", "plasma", "membrane", "initially", "proposed", "to", "be", "mediated", "by", "C0080058#ent", "<e2>", "interaction", "with", "the", "RAF", "Ras", "binding", "domain", "RBD", ")", "."], "h": {"id": "C0104940", "name": "C0104940#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [13, 14]}}
{"token": ["Tetanus", "and", "botulinum", "neurotoxins", "block", "C0243051#ent", "<e1>", "release", "by", "the", "enzymatic", "cleavage", "C0086376#ent", "<e2>", "identified", "as", "critical", "for", "synaptic", "vesicle", "exocytosis", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["A", "reproducible", "and", "selective", "method", "developed", "for", "the", "analysis", "of", "three", "anti-pschycotics", ",", "i.e.", "haloperidol", ",", "trifluoperazine", "and", "C0041009#ent", "<e1>", "in", "bulk", "and", "dosage", "forms", "using", "packed", "column", "supercritical", "fluid", "chromatography", "C0723176#ent", "<e2>", ")", "."], "h": {"id": "C0041009", "name": "C0041009#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0723176", "name": "C0723176#ent", "pos": [31, 32]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "influence", "of", "C0042291#ent", "<e1>", "and", "topiramate", "(", "TPM", ")", "on", "adiponectin", "binding", "receptors", "adipoR1", "and", "C1540189#ent", "<e2>", ",", "in", "human", "liver", "cancer", "cells", "HepG2", "."], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1540189", "name": "C1540189#ent", "pos": [24, 25]}}
{"token": ["In", "support", "of", "a", "strongly", "conserved", "functional", "interaction", "between", "Hsp110", "and", "C1527149#ent", "<e1>", ",", "C3889989#ent", "<e2>", "is", "shown", "to", "associate", "with", "and", "promote", "nucleotide", "exchange", "human", "C1527149#ent", "<e1>", "."], "h": {"id": "C3889989", "name": "C3889989#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [11, 12]}}
{"token": ["While", "the", "correlation", "between", "Helicobacter", "pylori", "C0030920#ent", "<e1>", "accepted", "worldwide", ",", "the", "role", "of", "C1415692#ent", "<e2>", "in", "functional", "dyspepsia", "is", "still", "a", "debatable", "issue", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [14, 15]}}
{"token": ["We", "have", "used", "inhibitors", "to", "elucidate", "the", "relation", "between", "C1413347#ent", "<e1>", "acyl-CoA", "hydrolase", "ACH", ")", ",", "and", "C1258847#ent", "<e2>", "activities", "in", "rat", "liver", "."], "h": {"id": "C1413347", "name": "C1413347#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [17, 18]}}
{"token": ["To", "further", "characterize", "the", "monocytic", "cells", "this", "clinical", "state", "we", "analyzed", "their", "expression", "of", "C1413243#ent", "<e1>", ",", "the", "most", "important", "C2985420#ent", "<e2>"], "h": {"id": "C1413243", "name": "C1413243#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2985420", "name": "C2985420#ent", "pos": [20, 21]}}
{"token": ["The", "oxygen", "plasma", "treatment", "of", "activated", "carbon", "fibers", "(", "C1838121#ent", "<e1>", ")", "was", "carried", "out", "to", "introduce", "oxygen-containing", "groups", "onto", "C0524928#ent", "<e2>", "surfaces", "."], "h": {"id": "C1838121", "name": "C1838121#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [20, 21]}}
{"token": ["After", "oral", "administration", "C0074554#ent", "<e1>", "(", "50", "mg/kg/day", ")", "for", "2", "weeks", ",", "serum", "C0010287#ent", "<e2>", "was", "elevated", "in", "5", "of", "7", "rabbits", ";", "degenerating", "or", "necrotic", "fibers", "seen", "in", "3", "rabbits", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010287", "name": "C0010287#ent", "pos": [14, 15]}}
{"token": ["Brain", "amino", "acid", "concentrations", "were", "little", "affected", "by", "C1412332#ent", "<e1>", "and", "did", "not", "show", "consistent", "changes", "after", "the", "C2917660#ent", "<e2>", "treatments", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [18, 19]}}
{"token": ["These", "results", "demonstrated", "that", "the", "HNF-1", "binding", "site", "played", "a", "major", "role", "in", "regulation", "of", "the", "C1412332#ent", "<e1>", "promoter", "by", "C2917660#ent", "<e2>", "availability", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [20, 21]}}
{"token": ["C0014121#ent", "<e1>", "prophylaxis", "should", "be", "emphasized", "in", "patients", "with", "C0035439#ent", "<e2>", "or", "pulmonary", "stenosis"], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035439", "name": "C0035439#ent", "pos": [9, 10]}}
{"token": ["These", "2", "C0949738#ent", "<e1>", "showed", "no", "effect", "the", "inhibition", "of", "C0009014#ent", "<e2>", "for", "contractile", "response", "rat", "vas", "deferens", "to", "field", "stimulation", "and", "their", "selectivity", "ratios", "to", "block", "alpha", "1", "alpha", "2", "adrenoceptors", "57.5", "and", "47.9", ",", "respectively", "."], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [10, 11]}}
{"token": ["This", "study", "reports", "that", "patients", "with", "neonatal", "adrenoleukodystrophy", "and", "C0043459#ent", "<e1>", "excrete", "a", "very", "peculiar", "pattern", "of", "C3541407#ent", "<e2>"], "h": {"id": "C0043459", "name": "C0043459#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541407", "name": "C3541407#ent", "pos": [17, 18]}}
{"token": ["Extracorporeal", "photopheresis", "ECP", ")", "has", "proven", "to", "be", "a", "very", "effective", "treatment", "modality", "cutaneous", "T", "cell", "lymphoma", "C0018133#ent", "<e1>", "certain", "autoimmune", "diseases", "as", "C1290138#ent", "<e2>", "pemphigus", "."], "h": {"id": "C0018133", "name": "C0018133#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [23, 24]}}
{"token": ["A", "bilateral", "injection", "of", "C0000544#ent", "<e1>", "5,6-DHT", ")", "into", "the", "C2986870#ent", "<e2>", "induced", "in", "this", "structure", "an", "average", "70", "%", "reduction", "in", "the", "level", "of", "endogenous", "serotonin", "."], "h": {"id": "C0000544", "name": "C0000544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986870", "name": "C2986870#ent", "pos": [10, 11]}}
{"token": ["However", ",", "use", "of", "C0065374#ent", "<e1>", "in", "our", "subjects", "was", "associated", "with", "high", "incidence", "of", "C3815497#ent", "<e2>", "(", "48", "%", ")", ",", "possibly", "limiting", "its", "use", "in", "this", "population", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3815497", "name": "C3815497#ent", "pos": [15, 16]}}
{"token": ["Certain", "clinical", "manifestations", "laboratory", "changes", "help", "to", "distinguish", "C1175175#ent", "<e1>", "from", "other", "C0392171#ent", "<e2>"], "h": {"id": "C1175175", "name": "C1175175#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0392171", "name": "C0392171#ent", "pos": [12, 13]}}
{"token": ["A", "simple", "definition", "for", "pause", "strength", "C2697954#ent", "<e1>", "has", "been", "given", ",", "quantitatively", "describing", "transcriptional", "pausing", "C0035678#ent", "<e2>"], "h": {"id": "C2697954", "name": "C2697954#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [16, 17]}}
{"token": ["This", "methionyl-tRNA", "is", "formylated", "by", "a", "C1530787#ent", "<e1>", "present", "in", "wheat", "extracts", "and", "functions", "in", "chain", "initiation", "C3179066#ent", "<e2>", "as", "formylmethionyl-tRNA", "."], "h": {"id": "C1530787", "name": "C1530787#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [17, 18]}}
{"token": ["Both", "isoforms", "of", "C1420439#ent", "<e1>", "function", "as", "C1336777#ent", "<e2>", "nuclear", "hormone", "receptors", "a", "ligand-", "and", "dose-dependent", "manner", "in", "CV-1", ",", "COS-1", ",", "and", "JEG-3", "cells", "."], "h": {"id": "C1420439", "name": "C1420439#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336777", "name": "C1336777#ent", "pos": [7, 8]}}
{"token": ["Although", "the", "incidence", "of", "C0341012#ent", "<e1>", "relatively", "unchanged", ",", "the", "incidence", "of", "C0019342#ent", "<e2>", "increasing", "significantly", "."], "h": {"id": "C0341012", "name": "C0341012#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019342", "name": "C0019342#ent", "pos": [12, 13]}}
{"token": ["C0076726#ent", "<e1>", "KLK1", "and", "the", "kallikrein-related", "peptidases", "C0618743#ent", "<e2>", "-", "15", "are", "a", "subfamily", "of", "serine", "proteases", "have", "defined", "or", "proposed", "roles", "in", "a", "range", "of", "central", "nervous", "system", "CNS", ")", "and", "non-CNS", "pathologies", "."], "h": {"id": "C0076726", "name": "C0076726#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [7, 8]}}
{"token": ["Prostate-specific", "antigen", "PSA", ")", "and", "human", "C0076726#ent", "<e1>", "hK2", ")", "are", "two", "closely", "related", "C0618743#ent", "<e2>", ",", "primarily", "produced", "by", "the", "prostate", "."], "h": {"id": "C0076726", "name": "C0076726#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [14, 15]}}
{"token": ["Rat", "intestinal", "tissue", "contains", "a", "kinin", "forming", "enzyme", "having", "a", "molecular", "weight", "to", "those", "of", "C0076726#ent", "<e1>", "different", "from", "those", "of", "the", "rat", "plasma", "C0618743#ent", "<e2>", "."], "h": {"id": "C0076726", "name": "C0076726#ent", "pos": [15, 16]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [24, 25]}}
{"token": ["PSA", "and", "human", "C0076726#ent", "<e1>", "hK2", ",", "previously", "called", "C0618743#ent", "<e2>", ")", "share", "extensive", "homology", "and", "are", "both", "produced", "in", "the", "prostate", "under", "androgen", "control"], "h": {"id": "C0076726", "name": "C0076726#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [9, 10]}}
{"token": ["C0054203#ent", "<e1>", "was", "about", "3", "times", "less", "potent", "than", "C0020223#ent", "<e2>", "in", "producing", "tachycardia", "in", "spontaneously", "hypertensive", "and", "normotensive", "rats", "when", "compared", "at", "equihypotensive", "doses", "."], "h": {"id": "C0054203", "name": "C0054203#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [9, 10]}}
{"token": ["After", "single", "oral", "administration", ",", "C0054203#ent", "<e1>", "was", "about", "8", "times", "less", "potent", "than", "C0020223#ent", "<e2>", "in", "increasing", "plasma", "renin", "activity", "in", "normotensive", "rats", "."], "h": {"id": "C0054203", "name": "C0054203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [14, 15]}}
{"token": ["In", "analogy", "with", "the", "C0297817#ent", "<e1>", "Escherichia", "coli", "protein", "was", "called", "C0061505#ent", "<e2>", "[", "Holmgren", ",", "A.", "(", "1976", ")", "Proc", "."], "h": {"id": "C0297817", "name": "C0297817#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0061505", "name": "C0061505#ent", "pos": [11, 12]}}
{"token": ["Mean", "+", "/-", "SD", "follow-up", "was", "9.5", "+", "/-", "6.4", "years", "for", "the", "C0520909#ent", "<e1>", "group", "and", "6.2", "+", "/-", "2.7", "years", "for", "the", "C0010592#ent", "<e2>", "group", "."], "h": {"id": "C0520909", "name": "C0520909#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [24, 25]}}
{"token": ["The", "500-kDa", "protein", "to", "the", "LDL-receptor", "superfamily", "of", "C0072522#ent", "<e1>", ",", "claimed", "to", "function", "primarily", "as", "C1418944#ent", "<e2>", "characterized", "by", "functionally", "important", "calcium-binding", "capacity", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418944", "name": "C1418944#ent", "pos": [16, 17]}}
{"token": ["The", "tumor-suppressor", "retinoblastoma", "protein", ",", "a", "substrate", "of", "cyclin-dependent", "kinase", "was", "phosphorylated", "on", "a", "C0243045#ent", "<e1>", "the", "global", "insult", ";", "this", "phosphorylation", "was", "inhibited", "by", "C0281603#ent", "<e2>", "administration", "."], "h": {"id": "C0243045", "name": "C0243045#ent", "pos": [14, 15]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0281603", "name": "C0281603#ent", "pos": [25, 26]}}
{"token": ["Inhibition", "of", "MLL2", "expression", "decreased", "the", "C4284890#ent", "<e1>", "expression", "of", "ERalpha", "target", "genes", "C0007427#ent", "<e2>", "to", "a", "lesser", "extent", "pS2", "."], "h": {"id": "C4284890", "name": "C4284890#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [13, 14]}}
{"token": ["Similarly", ",", "the", "fact", "that", "the", "presence", "and", "gene", "dosage", "C1415576#ent", "<e1>", "alleles", "affect", "the", "course", "and", "outcome", "of", "C0003873#ent", "<e2>", "likewise", "been", "seen", "in", "most", "(", "although", "not", "all", ")", "studies", "."], "h": {"id": "C1415576", "name": "C1415576#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["To", "assess", "the", "association", "between", "C1415576#ent", "<e1>", "and", "the", "pathogenesis", "of", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "in", "the", "Japanese", "population", ",", "we", "typed", "for", "HLA-DRB1", "alleles", "852", "Japanese", "patients", "."], "h": {"id": "C1415576", "name": "C1415576#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}}
{"token": ["Substantially", "higher", "acetylcholine", "levels", "were", "noted", "when", "an", "exogenous", "C0008425#ent", "<e1>", "included", "in", "the", "perfusion", "buffer", "but", "C1417839#ent", "<e2>", "treatment-related", "differences", "were", "substantially", "lower", "in", "magnitude", "under", "those", "conditions", "."], "h": {"id": "C0008425", "name": "C0008425#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417839", "name": "C1417839#ent", "pos": [17, 18]}}
{"token": ["Consequently", ",", "wing", "cells", "transformed", "into", "cells", "that", "appear", "to", "be", "intermediates", "between", "C3538717#ent", "<e1>", "and", "haltere", "cells", ",", "contesting", "the", "view", "that", "C0017347#ent", "<e2>", "as", "binary", "switches"], "h": {"id": "C3538717", "name": "C3538717#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017347", "name": "C0017347#ent", "pos": [23, 24]}}
{"token": ["Correspondence", "relationships", "C3538717#ent", "<e1>", "and", "haltere", "sensory", "organ", "fields", "are", "resolved", "by", "exploring", "C0017347#ent", "<e2>", "detail", "."], "h": {"id": "C3538717", "name": "C3538717#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017347", "name": "C0017347#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "the", "C3538717#ent", "<e1>", "homology", "with", "the", "Drosophila", "C0017347#ent", "<e2>", "regions", "I", "II", ",", "and", "III", ",", "suggesting", "that", "HNF-3", "may", "be", "its", "mammalian", "homolog", "."], "h": {"id": "C3538717", "name": "C3538717#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017347", "name": "C0017347#ent", "pos": [9, 10]}}
{"token": ["C0002600#ent", "<e1>", "and", "imipramine", ",", "two", "C0003289#ent", "<e2>", "have", "been", "studied", "to", "evaluate", "their", "phototoxic", "potential", "using", "various", "models", "."], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [6, 7]}}
{"token": ["C2987048#ent", "<e1>", "20", "-", "1724", "(", "an", "phosphodiesterase", "inhibitor", ",", "and", "C0072171#ent", "<e2>", "(", "a", "xanthine", "derivative", ",", "but", "not", "8-bromo-cGMP", "(", "cell", "permeable", "cGMP", "analog", "."], "h": {"id": "C2987048", "name": "C2987048#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072171", "name": "C0072171#ent", "pos": [11, 12]}}
{"token": ["This", "permitted", "the", "construction", "of", "single-copy", "lacZ", "operon", "fusions", ",", "which", "were", "used", "to", "examine", "the", "C1710463#ent", "<e1>", "the", "two", "C0029073#ent", "<e2>", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [20, 21]}}
{"token": ["Similar", "studies", "on", "the", "C1710463#ent", "<e1>", "fusions", "in", "the", "gal", "and", "C0029073#ent", "<e2>", "also", "necessary", "for", "colanic", "acid", "synthesis", ",", "do", "not", "show", "significant", "regulation", "by", "the", "lon", "locus"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [11, 12]}}
{"token": ["Both", "kindreds", "have", "essentially", "identical", "C0031065#ent", "<e1>", ";", "however", ",", "kindred", "P", "has", "C0018784#ent", "<e2>", "associated", "with", "C0031065#ent", "<e1>", ",", "while", "kindred", "C", "does", "not", "."], "h": {"id": "C0031065", "name": "C0031065#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [13, 14]}}
{"token": ["They", "also", "discuss", "the", "other", "ocular", "manifestations", "the", "C0031065#ent", "<e1>", "and", "the", "C0018784#ent", "<e2>"], "h": {"id": "C0031065", "name": "C0031065#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [12, 13]}}
{"token": ["The", "characteristics", "of", "C0085388#ent", "<e1>", "and", "the", "role", "of", "C3539185#ent", "<e2>", "in", "TBM", "patients", "are", "discussed", "."], "h": {"id": "C0085388", "name": "C0085388#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539185", "name": "C3539185#ent", "pos": [9, 10]}}
{"token": ["This", "indicates", "that", "the", "incidence", "and", "severity", "of", "C0017661#ent", "<e1>", "within", "this", "family", "can", "not", "be", "attributed", "to", "the", "C1416890#ent", "<e2>", "genotype", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416890", "name": "C1416890#ent", "pos": [19, 20]}}
{"token": ["This", "is", "further", "supported", "by", "the", "fact", "that", "C4084872#ent", "<e1>", ",", "in", "contrast", "to", "the", "C1947941#ent", "<e2>", ",", "is", "not", "absolutely", "essential", "for", "viral", "growth"], "h": {"id": "C4084872", "name": "C4084872#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [15, 16]}}
{"token": ["We", "hypothesized", "that", "this", "neuropathology", "occurs", "when", "cerebral", "endothelial", "cells", "the", "blood-brain", "barrier", "sensitized", "by", "exogenous", "C0812246#ent", "<e1>", "and", "stimulated", "by", "C1420498#ent", "<e2>", ",", "produce", "and", "release", "proinflammatory", "cytokines"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420498", "name": "C1420498#ent", "pos": [21, 22]}}
{"token": ["Cells", "pretreated", "with", "C0812246#ent", "<e1>", "were", "more", "sensitive", "to", "C1420498#ent", "<e2>", ",", "displaying", "greater", "Stx1-induction", "of", "mRNA", "for", "C0812246#ent", "<e1>", ",", "IL-1beta", ",", "and", "IL-6", ",", "and", "secretion", "of", "IL-6", "and", "IL-8", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420498", "name": "C1420498#ent", "pos": [9, 10]}}
{"token": ["We", "have", "shown", "previously", "that", "short-term", "nutritional", "deprivation", "a", "C1420295#ent", "<e1>", "loss", "of", "liver", "ornithine", "decarboxylase", "C1422630#ent", "<e2>", ")", "induction", "after", "isoproterenol", ",", "phenylephrine", ",", "or", "glucagon", "administration", "in", "rat", "pups", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422630", "name": "C1422630#ent", "pos": [16, 17]}}
{"token": ["Tumor", "necrosis", "C1705592#ent", "<e1>", "toxic", "liver", "injury", "results", "from", "JNK2-dependent", "activation", "of", "C1705065#ent", "<e2>", "and", "the", "mitochondrial", "death", "pathway"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [12, 13]}}
{"token": ["Gel", "mobility", "shift", "DNase", "I", "footprinting", "analyses", "that", "all", "three", "regions", "contained", "binding", "sites", "the", "C1420631#ent", "<e1>", "HNF1", ")", ",", "a", "transcriptional", "regulator", "of", "HNF1alpha", "and", "C2348633#ent", "<e2>", "homodimers", "."], "h": {"id": "C1420631", "name": "C1420631#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2348633", "name": "C2348633#ent", "pos": [26, 27]}}
{"token": ["Hepatocyte", "nuclear", "factor", "1alpha", "C1420631#ent", "<e1>", ")", "and", "HNF1beta", "(", "or", "C2348633#ent", "<e2>", ")", "are", "closely", "related", "transcription", "factors", "expressed", "in", "liver", ",", "kidney", ",", "gut", ",", "and", "pancreatic", "beta-cells"], "h": {"id": "C1420631", "name": "C1420631#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2348633", "name": "C2348633#ent", "pos": [11, 12]}}
{"token": ["Low-titer", "polyclonal", "antibodies", "C0017083#ent", "<e1>", "occur", "frequently", "in", "a", "variety", "of", "diseases", ",", "including", "C0004364#ent", "<e2>", "neurological", "symptoms"], "h": {"id": "C0017083", "name": "C0017083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [14, 15]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "similar", "changes", "contribute", "to", "the", "gradual", "loss", "of", "muscle", "function", "age", "in", "mdx", "and", "C2698698#ent", "<e1>", "a", "model", "of", "human", "motor", "and", "sensory", "neuropathy", "type", "1A", "C0270911#ent", "<e2>", ")", "."], "h": {"id": "C2698698", "name": "C2698698#ent", "pos": [19, 20]}, "relation": "gene_associated_with_disease", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [31, 32]}}
{"token": ["This", "indicates", "that", "the", "gene", "defined", "by", "the", "UVsN1", "mutation", "represents", "a", "homolog", "of", "the", "E.", "coli", "gene", ",", "implying", "the", "presence", "in", "M.", "luteus", "an", "C0026741#ent", "<e1>", "homologous", "to", "the", "E.", "coli", "C0059229#ent", "<e2>"], "h": {"id": "C0026741", "name": "C0026741#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0059229", "name": "C0059229#ent", "pos": [33, 34]}}
{"token": ["Together", "with", "previous", "synteny", "mapping", "of", "bovine", "chromosome", "12", "genes", "fms-related", "tyrosine", "kinase", "C1414459#ent", "<e1>", "5-hydroxytryptamine", "receptor", "2", "this", "assignment", "further", "indicates", "conservation", "between", "human", "C0795849#ent", "<e2>", "bovine", "chromosome", "12"], "h": {"id": "C1414459", "name": "C1414459#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0795849", "name": "C0795849#ent", "pos": [25, 26]}}
{"token": ["This", "suggested", "that", "a", "linkage", "may", "exist", "between", "a", "gene", "for", "alcoholism", "and", "the", "C1414459#ent", "<e1>", "locus", "on", "C0795849#ent", "<e2>"], "h": {"id": "C1414459", "name": "C1414459#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0795849", "name": "C0795849#ent", "pos": [18, 19]}}
{"token": ["The", "C1705526#ent", "<e1>", "for", "a", "unique", "protein", "eliciting", "well-known", "tumor", "suppressor", "gene", "C1332010#ent", "<e2>", ")", "properties", "that", "mediate", "cellular", "response", "DNA", "damage", "e.g.", ",", "cell", "cycle", "arrest", "apoptosis", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332010", "name": "C1332010#ent", "pos": [12, 13]}}
{"token": ["There", "was", "a", "strong", "association", "between", "resistance", "to", "spectinomycin", "and", "resistance", "to", "other", "C1136254#ent", "<e1>", "in", "particular", ",", "C0038745#ent", "<e2>", "and", "chloramphenicol", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0038745", "name": "C0038745#ent", "pos": [18, 19]}}
{"token": ["In", "developing", "thymocytes", ",", "NBS1", "and", "gamma-H2AX", "form", "nuclear", "foci", "colocalize", "with", "the", "C0524890#ent", "<e1>", "response", "to", "C0085218#ent", "<e2>", "RAG", ")", "protein-mediated", "VDJ", "cleavage", "."], "h": {"id": "C0524890", "name": "C0524890#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085218", "name": "C0085218#ent", "pos": [17, 18]}}
{"token": ["Similar", "results", "were", "obtained", "with", "a", "second", "rotavirus", "strain", "EC(w", ")", ")", "in", "which", "virus", "was", "shed", "chronically", "in", "stool", "samples", "low", "levels", "in", "C0524890#ent", "<e1>", "knockout", "mice", "at", "high", "levels", "in", "C0085218#ent", "<e2>", "knockout", "mice"], "h": {"id": "C0524890", "name": "C0524890#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0085218", "name": "C0085218#ent", "pos": [32, 33]}}
{"token": ["We", "previously", "demonstrated", "that", "C3489445#ent", "<e1>", "(", "C1705725#ent", "<e2>", ")", "stimulates", "NF-kappaB", "activation", "and", "this", "function", "of", "C1705725#ent", "<e2>", "requires", "phosphatidylinositol", "3-kinase", "PI3K", "."], "h": {"id": "C3489445", "name": "C3489445#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [7, 8]}}
{"token": ["The", "alpha-2A", "preferential", "C2987634#ent", "<e1>", "oxymetazoline", "induced", "in", "the", "mouse", "a", "C1321567#ent", "<e2>", "response", "similar", "to", "that", "of", "the", "nonselective", "alpha-2", "adrenoceptor", "agonist", "UK", "14.304", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1321567", "name": "C1321567#ent", "pos": [11, 12]}}
{"token": ["C2987634#ent", "<e1>", "of", "the", "nuclear", "receptor", "peroxisome", "proliferator-activated", "receptor", "gamma", "PPAR", "gamma", "are", "pharmacologically", "active", "C1321567#ent", "<e2>", "act", "by", "increasing", "peripheral", "tissue", "sensitivity", "to", "insulin", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1321567", "name": "C1321567#ent", "pos": [15, 16]}}
{"token": ["Microinjection", "of", "C0770901#ent", "<e1>", "the", "substantia", "nigra", "pars", "reticulata", "bilaterally", ",", "converts", "non-convulsant", "dose", "C0770456#ent", "<e2>", "100", "mg/kg", ",", "into", "a", "convulsant", "one", "."], "h": {"id": "C0770901", "name": "C0770901#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0770456", "name": "C0770456#ent", "pos": [14, 15]}}
{"token": ["The", "alterations", "of", "three", "erythrocyte", "purine", "enzymes", "studied", "in", "12", "patients", "with", "diseases", "associated", "with", "reticulocytosis", ",", "two", "patients", "with", "a", "partial", "deficiency", "C0023374#ent", "<e1>", "seven", "patients", "with", "severe", "C0002888#ent", "<e2>", "and", "14", "normal", "subjects"], "h": {"id": "C0023374", "name": "C0023374#ent", "pos": [23, 24]}, "relation": "has_manifestation", "t": {"id": "C0002888", "name": "C0002888#ent", "pos": [29, 30]}}
{"token": ["C0023374#ent", "<e1>", "phosphoribosylpyrophosphate", "synthetase", "increased", "in", "C0002888#ent", "<e2>", "but", "were", "not", "correlated", "with", "the", "reticulocyte", "percentage", "and", "did", "not", "have", "a", "consistent", "change", "in", "the", "half", "life", "the", "other", "disorders", "studied", "."], "h": {"id": "C0023374", "name": "C0023374#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0002888", "name": "C0002888#ent", "pos": [6, 7]}}
{"token": ["The", "hypocholesterolemic", "activity", "C0106127#ent", "<e1>", "and", "its", "hydrogenated", "product", "C0106126#ent", "<e2>", "(", "dihydrositosterol", "or", "stigmastanol", ")", "has", "been", "compared", "in", "young", "male", "rats", "."], "h": {"id": "C0106127", "name": "C0106127#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0106126", "name": "C0106126#ent", "pos": [9, 10]}}
{"token": ["With", "both", "techniques", "the", "same", "pattern", "of", "labelling", "was", "observed", ",", "confirming", "that", "in", "the", "morning", "the", "ratio", "between", "the", "C0311284#ent", "<e1>", "and", "the", "C1420713#ent", "<e2>", "differs", "throughout", "the", "cornea", "."], "h": {"id": "C0311284", "name": "C0311284#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1420713", "name": "C1420713#ent", "pos": [24, 25]}}
{"token": ["Defects", "in", "C1333237#ent", "<e1>", "be", "responsible", "for", "the", "C4255166#ent", "<e2>", "of", "mutations", "in", "key", "genes", "in", "cancer", "cells"], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4255166", "name": "C4255166#ent", "pos": [8, 9]}}
{"token": ["The", "possibility", "that", "this", "effect", "of", "C0009079#ent", "<e1>", "is", "mediated", "via", "its", "interference", "with", "the", "activity", "of", "C3887648#ent", "<e2>", "GABA", "neurons", "is", "discussed", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [17, 18]}}
{"token": ["Unlike", "C0009079#ent", "<e1>", ",", "it", "does", "not", "significantly", "enhance", "C3887648#ent", "<e2>", "(", "noradrenaline", ",", "NA)-", "or", "5-hydroxytryptamine", "turnover", "it", "does", "not", "increase", "prolactin", "blood", "levels", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "C0009079#ent", "<e1>", "and", "olanzapine", "increase", "C3887648#ent", "<e2>", "release", "by", "stimulating", "noradrenergic", "neuronal", "activity", "the", "locus", "coeruleus", ",", "consequently", ",", "increased", "C3887648#ent", "<e2>", "induce", "Fos", "expression", "in", "the", "mPFC", "via", "beta-adrenergic", "receptors"], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [9, 10]}}
{"token": ["In", "part", "A", "a", "brief", "overview", "of", "systemic", "side", "effects", "of", "ophthalmic", "drugs", "as", "antibiotics", ",", "betablockers", ",", "C0242889#ent", "<e1>", ",", "mydriatics", "and", "C0007036#ent", "<e2>", "given", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0007036", "name": "C0007036#ent", "pos": [23, 24]}}
{"token": ["Broad", "families", "drugs", "are", "available", "including", "C0242889#ent", "<e1>", "topical", "and", "C0007036#ent", "<e2>", "prostaglandin", "analogs", "adrenoceptor", "agonists", "parasympathomimetics", ",", "and", "combination", "preparations"], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007036", "name": "C0007036#ent", "pos": [10, 11]}}
{"token": ["These", "data", "possibly", "explain", "the", "origin", "of", "the", "increased", "content", "of", "C0042071#ent", "<e1>", "activity", ",", "IGF-1", "bioavailability", ",", "and", "NH(2)-truncated", "forms", "of", "C0123707#ent", "<e2>", "in", "the", "peritoneal", "fluid", "women", "with", "endometriosis", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0123707", "name": "C0123707#ent", "pos": [22, 23]}}
{"token": ["Urokinase", "activity", "detected", "in", "the", "conditioned", "media", "depressed", "by", "Pefabloc", ",", "suggesting", "that", "the", "C0042071#ent", "<e1>", "involved", "in", "the", "proteolysis", "of", "C0123707#ent", "<e2>", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0123707", "name": "C0123707#ent", "pos": [21, 22]}}
{"token": ["C0007332#ent", "<e1>", "and", "maltodextrin", "C2697833#ent", "<e2>", "X-70", "on", "Escherichia", "coli", ":", "K88", "adhesion", "in", "the", "gastrointestinal", "tract", "11", "conventional", "and", "6", "gnotobiotic", "piglets", "was", "investigated", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697833", "name": "C2697833#ent", "pos": [4, 5]}}
{"token": ["Of", "6", "C0003374#ent", "<e1>", "tested", ",", "quinine", "and", "C0282331#ent", "<e2>", "were", "the", "most", "effective", "inhibitors", "and", "mefloquine", "was", "the", "least", "effective", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0282331", "name": "C0282331#ent", "pos": [8, 9]}}
{"token": ["C0011847#ent", "<e1>", "in", "the", "male", "rat", "had", "no", "effect", "C1258666#ent", "<e2>", "its", "contents", "and", "isoform", "distribution", "of", "LDH", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [9, 10]}}
{"token": ["These", "data", "suggest", "both", "beta1", "and", "beta3", "adrenergic", "receptors", "C0001492#ent", "<e1>", "deficient", "with", "age", "in", "rodent", "C1412726#ent", "<e2>", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [16, 17]}}
{"token": ["Adrenergic", "agonists", "stimulated", "C0001492#ent", "<e1>", "membranes", "from", "C1412726#ent", "<e2>", "of", "both", "warm-", "and", "cold-acclimated", "guinea", "pigs", "also", "via", "a", "beta", "1-adrenoceptor", "beta", "3-adrenergic", "agonists", "no", "effect"], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [7, 8]}}
{"token": ["To", "review", "existing", "treatments", "for", "C0009443#ent", "<e1>", "and", "summarize", "data", "available", "on", "the", "use", "of", "a", "C1874300#ent", "<e2>", "azelastine", ")", "in", "treating", "allergic", "and", "nonallergic", "vasomotor", "rhinitis"], "h": {"id": "C0009443", "name": "C0009443#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1874300", "name": "C1874300#ent", "pos": [16, 17]}}
{"token": ["We", "report", "a", "patient", "with", "C1832661#ent", "<e1>", "failure", "to", "thrive", ",", "exocrine", "pancreas", "insufficiency", "growth", "hormone", "deficiency", "severe", "C0151747#ent", "<e2>"], "h": {"id": "C1832661", "name": "C1832661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151747", "name": "C0151747#ent", "pos": [18, 19]}}
{"token": ["The", "C0028860#ent", "<e1>", "Lowe", "(", "OCRL", ")", "is", "a", "C0019247#ent", "<e2>", "by", "congenital", "cataract", "mental", "retardation", "renal", "tubular", "dysfunction", "and", "progressive", "renal", "insufficiency"], "h": {"id": "C0028860", "name": "C0028860#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [9, 10]}}
{"token": ["The", "oculocerebrorenal", "syndrome", "Lowe", "(", "C0028860#ent", "<e1>", ")", "is", "a", "C0019247#ent", "<e2>", "by", "congenital", "cataract", "mental", "retardation", "renal", "tubular", "dysfunction", "and", "progressive", "renal", "insufficiency"], "h": {"id": "C0028860", "name": "C0028860#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [10, 11]}}
{"token": ["Clinical", "and", "laboratory", "evaluation", "of", "pectins", "application", "efficacy", "demonstrated", "that", "the", "patients", "treated", "with", "C0070203#ent", "<e1>", "has", "lower", "frequency", "of", "bacteriemia", ",", "intoxication", ",", "C0032965#ent", "<e2>", "lethality", "."], "h": {"id": "C0070203", "name": "C0070203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032965", "name": "C0032965#ent", "pos": [24, 25]}}
{"token": ["Several", "common", "features", "were", "observed", ",", "including", "the", "presence", "of", "nucleosidases", ",", "catabolic", "phosphorylases", "phosphoribosyltransferases", ",", "kinases", "and", "C0010723#ent", "<e1>", "the", "apparent", "absence", "of", "C1412387#ent", "<e2>", "anabolic", "purine", "phosphorylase", "cytosine", "deaminase"], "h": {"id": "C0010723", "name": "C0010723#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412387", "name": "C1412387#ent", "pos": [24, 25]}}
{"token": ["Tristetraprolin-deficient", "[", "TTP", "(", "-/-", ")", "]", "mice", "exhibit", "a", "complex", "syndrome", "myeloid", "hyperplasia", "C1516009#ent", "<e1>", ",", "dermatitis", ",", "autoimmunity", ",", "and", "C0003864#ent", "<e2>"], "h": {"id": "C1516009", "name": "C1516009#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [22, 23]}}
{"token": ["In", "a", "number", "of", "instances", ",", "the", "symptoms", "were", "due", "to", "more", "than", "one", "C0013227#ent", "<e1>", "being", "given", "to", "the", "patient", ",", "among", "which", "were", "C0304370#ent", "<e2>", "non-phenothiazine", "tranquilizers", "metoclopramide", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0304370", "name": "C0304370#ent", "pos": [25, 26]}}
{"token": ["One", "hundred", "and", "fifty", "consecutive", "patients", "with", "active", ",", "C0003873#ent", "<e1>", "assessed", "and", "treated", "with", "gold", ",", "C0030817#ent", "<e2>", ",", "chloroquine", "or", "dapsone", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [17, 18]}}
{"token": ["In", "vivo", "C1419284#ent", "<e1>", "selectively", "catalyzes", "nucleotide", "exchange", "N-", "and", "Ki-Ras", ",", "but", "not", "C0079972#ent", "<e2>", "."], "h": {"id": "C1419284", "name": "C1419284#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079972", "name": "C0079972#ent", "pos": [14, 15]}}
{"token": ["When", "microglia", "were", "activated", ",", "there", "was", "an", "upregulation", "of", "transcripts", "for", "nine", "C0025543#ent", "<e1>", ",", "and", "reduction", "of", "C1336630#ent", "<e2>", "."], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1336630", "name": "C1336630#ent", "pos": [19, 20]}}
{"token": ["The", "clinical", "and", "histological", "features", "are", "typical", "of", "a", "C1706192#ent", "<e1>", "yet", "in", "vitro", "activities", "of", "C0003940#ent", "<e2>", "B", "and", "cerebroside", "sulfatase", "normal", "."], "h": {"id": "C1706192", "name": "C1706192#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003940", "name": "C0003940#ent", "pos": [16, 17]}}
{"token": ["OBJECTIVE", "To", "investigate", "the", "expression", "and", "pathogenic", "role", "of", "C1334507#ent", "<e1>", "MIF", ")", "in", "human", "C0748355#ent", "<e2>", ")", "METHODS", "The", "serum", "level", "of", "MIF", "in", "ARDS", "patients", "and", "normal", "persons", "measured", "by", "ELISA", "method"], "h": {"id": "C1334507", "name": "C1334507#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0748355", "name": "C0748355#ent", "pos": [15, 16]}}
{"token": ["Although", "the", "majority", "(", "60", "%", ")", "of", "C1875400#ent", "<e1>", "among", "infants", "with", "C3897032#ent", "<e2>", "serotype", "III", "serotype", "Ia", "23", "%", ")", "was", "also", "common", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3897032", "name": "C3897032#ent", "pos": [13, 14]}}
{"token": ["However", ",", "abnormal", "angiogenesis", "also", "plays", "a", "major", "role", "in", "the", "pathogenesis", "of", "tumor", "growth", "rheumatoid", "arthritis", "C0004153#ent", "<e1>", "and", "various", "C0035309#ent", "<e2>", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035309", "name": "C0035309#ent", "pos": [21, 22]}}
{"token": ["Finally", ",", "we", "analyzed", "the", "gene", "expression", "profile", "C1416886#ent", "<e1>", "by", "cDNA", "microarray", "treatment", "with", "C0011777#ent", "<e2>", "."], "h": {"id": "C1416886", "name": "C1416886#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [15, 16]}}
{"token": ["Cocaine", ",", "dopamine", ",", "and", "the", "C1416886#ent", "<e1>", "agonist", "inhibited", "neurite-like", "process", "outgrowth", "in", "both", "C0011777#ent", "<e2>", "and", "NGF-induced", "GSras1", "cells", "."], "h": {"id": "C1416886", "name": "C1416886#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [15, 16]}}
{"token": ["Listeria", "monocytogenes", "an", "uncommon", "cause", "of", "C0085808#ent", "<e1>", "endocarditis", ",", "and", "other", "C0596270#ent", "<e2>"], "h": {"id": "C0085808", "name": "C0085808#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0596270", "name": "C0596270#ent", "pos": [12, 13]}}
{"token": ["Juvenile", "dermatomyositis", "C0263666#ent", "<e1>", ")", "is", "a", "C3266262#ent", "<e2>"], "h": {"id": "C0263666", "name": "C0263666#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3266262", "name": "C3266262#ent", "pos": [7, 8]}}
{"token": ["Active", "juvenile", "chronic", "arthritis", "JCA", ")", "is", "accompanied", "by", "C0002871#ent", "<e1>", "of", "C0008679#ent", "<e2>", "which", "may", "be", "indistinguishable", "from", "C0002871#ent", "<e1>", "due", "to", "iron", "deficiency"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [9, 10]}}
{"token": ["Examples", "include", "C0002871#ent", "<e1>", "of", "C0008679#ent", "<e2>", "iron", "deficiency", ",", "less", "commonly", ",", "megaloblastic", "anaemia", "C0002871#ent", "<e1>", "due", "to", "primary", "bone", "marrow", "failure"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [2, 3]}}
{"token": ["Because", "C0009325#ent", "<e1>", "is", "also", "the", "most", "important", "C0017366#ent", "<e2>", "the", "mammalian", "body", ",", "this", "provides", "a", "very", "useful", "imaging", "tool", "studying", "its", "distribution", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0017366", "name": "C0017366#ent", "pos": [8, 9]}}
{"token": ["We", "present", "a", "case", "of", "a", "37-year-old", "Nigerian", "male", "with", "schizophrenia", "and", "C0022806#ent", "<e1>", "who", "presented", "with", "delirium", "and", "C0029089#ent", "<e2>", "."], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029089", "name": "C0029089#ent", "pos": [19, 20]}}
{"token": ["Seventy-six", "Irish", "red", "white", "setter", "samples", "were", "tested", "for", "the", "recently", "documented", "C1706333#ent", "<e1>", "point", "mutation", "which", "manifests", "as", "canine", "C0272187#ent", "<e2>", "CLAD", ")", "in", "Irish", "setters", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0272187", "name": "C0272187#ent", "pos": [20, 21]}}
{"token": ["C1706333#ent", "<e1>", "is", "a", "key", "molecule", "of", "the", "AC", ",", "as", "C1706333#ent", "<e1>", "defects", "abrogate", "the", "adhesion", "of", "PMN", "and", "cause", "C0272187#ent", "<e1>", "an", "immunodeficient", "trait", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [0, 1]}, "relation": "gene_associated_with_disease", "t": {"id": "C0272187", "name": "C0272187#ent", "pos": [21, 22]}}
{"token": ["Its", "applicability", "was", "demonstrated", "with", "underivatized", "and", "dansyl", "amino", "acids", "a", "C0012512#ent", "<e1>", ",", "and", "drugs", "with", "C0002530#ent", "<e2>"], "h": {"id": "C0012512", "name": "C0012512#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002530", "name": "C0002530#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "JEG-3", "cells", "with", "okadaic", "acid", "dose-", "and", "time-dependent", "stimulation", "of", "C3890353#ent", "<e1>", "C2984553#ent", "<e2>", "expression", "without", "marked", "modification", "of", "expression", "of", "p120", "C2984553#ent", "<e2>", ",", "another", "isoform", "of", "C2984553#ent", "<e2>", "."], "h": {"id": "C3890353", "name": "C3890353#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2984553", "name": "C2984553#ent", "pos": [14, 15]}}
{"token": ["The", "cDNA", "species", "encoding", "p120", "and", "C3890353#ent", "<e1>", "C2984553#ent", "<e2>", "are", "identical", "except", "that", "C3890353#ent", "<e1>", "C2984553#ent", "<e2>", "cDNA", "contains", "a", "65-bp", "insert", "not", "present", "in", "p120", "cDNA", "."], "h": {"id": "C3890353", "name": "C3890353#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2984553", "name": "C2984553#ent", "pos": [8, 9]}}
{"token": ["Molecular", "genetic", "studies", "demonstrated", "that", "C1413855#ent", "<e1>", ",", "the", "gene", "encoding", "C0008381#ent", "<e2>", "is", "a", "major", "susceptibility", "locus", "for", "development", "of", "hyperandrogenism", "in", "PCOS", "."], "h": {"id": "C1413855", "name": "C1413855#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0008381", "name": "C0008381#ent", "pos": [11, 12]}}
{"token": ["11", "of", "19", "patients", "from", "whom", "only", "single", "sera", "obtained", "had", "C0281643#ent", "<e1>", "titres", "presumptive", "of", "C0036472#ent", "<e2>", "greater", "than", "or", "equal", "to", "1:160", ")", "."], "h": {"id": "C0281643", "name": "C0281643#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0036472", "name": "C0036472#ent", "pos": [16, 17]}}
{"token": ["Macrophage", "migration", "inhibitory", "factor", "MIF", ")", "is", "released", "into", "the", "intraluminal", "fluid", "C0008325#ent", "<e1>", "the", "rat", "complexed", "to", "C0051259#ent", "<e2>", "(", "A1-I3", ";", "a", "rodent", "proteinase", "inhibitor", "the", "alpha-macroglobulin", "family", "."], "h": {"id": "C0008325", "name": "C0008325#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0051259", "name": "C0051259#ent", "pos": [18, 19]}}
{"token": ["C0064113#ent", "<e1>", "is", "a", "new", "C0003308#ent", "<e2>"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [5, 6]}}
{"token": ["Successful", "treatment", "resection", "of", "the", "infected", "graft", ",", "restoration", "of", "circulation", "by", "extraanatomic", "bypass", ",", "and", "administration", "of", "amphotericin", "B", "C0064113#ent", "<e1>", ",", "a", "new", "C0003308#ent", "<e2>"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [20, 21]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [25, 26]}}
{"token": ["Candida", "species", "tested", "in", "vitro", "their", "susceptibility", "to", "ketoconazole", ",", "fluconazole", ",", "C0064113#ent", "<e1>", "and", "amphotericin", "B.", "MICs", "of", "the", "four", "C0003308#ent", "<e2>", "obtained", "for", "each", "yeast", "using", "a", "microdilution", "broth", "method", "in", "our", "laboratory", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [12, 13]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [21, 22]}}
{"token": ["The", "influence", "of", "C0003596#ent", "<e1>", ",", "levodopa", "and", "haloperidol", "was", "studied", "on", "C1564434#ent", "<e2>", "sleep", "using", "young", "chicks", "and", "rats", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1564434", "name": "C1564434#ent", "pos": [12, 13]}}
{"token": ["In", "refractory", "CDH", "with", "C1112466#ent", "<e1>", "features", ",", "a", "spinal", "tap", "exclude", "coexistent", "C0033845#ent", "<e2>", "papilledema", "may", "be", "indicated", "."], "h": {"id": "C1112466", "name": "C1112466#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033845", "name": "C0033845#ent", "pos": [13, 14]}}
{"token": ["Our", "study", "revealed", "that", "amputation", "is", "still", "being", "performed", "as", "a", "life-saving", "procedure", ",", "as", "44/87", "patients", "presented", "with", "C0017086#ent", "<e1>", "of", "a", "C0030196#ent", "<e2>", "."], "h": {"id": "C0017086", "name": "C0017086#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [23, 24]}}
{"token": ["In", "400", "patients", "who", "have", "undergone", "operations", "by", "one", "surgeon", ",", "the", "results", "are", "encouraging", "in", "cases", "of", "transient", "C0745413#ent", "<e1>", "hemodynamic", "lesions", "considered", "inoperable", "or", "inaccessible", "in", "the", "C0238051#ent", "<e2>"], "h": {"id": "C0745413", "name": "C0745413#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0238051", "name": "C0238051#ent", "pos": [29, 30]}}
{"token": ["C0003869#ent", "<e1>", "to", "occur", "in", "patients", "who", "have", "preexisting", "C0683381#ent", "<e2>", "especially", "if", "a", "systemic", "condition", "is", "known", "to", "predispose", "to", "infection", "is", "present", "."], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0683381", "name": "C0683381#ent", "pos": [9, 10]}}
{"token": ["A", "lot", "of", "recent", "molecular", "genetic", "experiments", "and", "many", "neuropathological", "analogies", "C0002395#ent", "<e1>", "C0013080#ent", "<e2>", "a", "damage", "on", "the", "chromosome", "21", "possible", "cause", "of", "C0002395#ent", "<e1>"], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [13, 14]}, "relation": "has_manifestation", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [11, 12]}}
{"token": ["A", "baculovirus", "odv-e66", "homologue", "is", "also", "present", "in", "OrV.", "Five", "ORFs", "encode", "proteins", "C1512488#ent", "<e1>", "to", "cellular", "thymidylate", "synthase", "TS", ")", ",", "patatin-like", "phospholipase", ",", "C1425005#ent", "<e2>", "Ser/Thr", "protein", "phosphatase", "and", "serine", "protease", "respectively", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1425005", "name": "C1425005#ent", "pos": [25, 26]}}
{"token": ["Citrin", "and", "aralar1", "are", "C1512488#ent", "<e1>", "to", "the", "C1425005#ent", "<e2>", "EF-hand", "Ca(2+)-binding", "motifs", "in", "their", "N-terminal", "domains", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425005", "name": "C1425005#ent", "pos": [8, 9]}}
{"token": ["In", "FPAEC", "in", "monoculture", "treated", "with", "-", "100", "microM", "H2O2", ",", "12", "microM", "had", "no", "effect", "on", "C1328053#ent", "<e1>", "promoter", "activity", "but", "it", "increased", "C0669365#ent", "<e2>", "by", "50", "%", "."], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}}
{"token": ["In", "this", "study", ",", "a", "PCR-RFLP", "procedure", "to", "detect", "the", "G894", "T", "polymorphism", "at", "the", "C1328053#ent", "<e1>", "was", "optimized", "by", "the", "introduction", "of", "a", "C0669365#ent", "<e2>", "cleavage", "site", "the", "amplification", "product"], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}}
{"token": ["Its", "C0003195#ent", "<e1>", "properties", "are", "very", "similar", "to", "those", "of", "C0034415#ent", "<e2>"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0034415", "name": "C0034415#ent", "pos": [10, 11]}}
{"token": ["A", "young", "girl", "C0017668#ent", "<e1>", "for", "WT1", "mutation", "IVS9", "+", "4C", ">", "T", ")", "and", "C0950122#ent", "<e2>", "a", "renal", "transplant", "the", "age", "of", "11", "years", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0950122", "name": "C0950122#ent", "pos": [15, 16]}}
{"token": ["C0054836#ent", "<e1>", "appears", "to", "be", "effective", "in", "preventing", "or", "reducing", "C0002962#ent", "<e2>", "to", "reduced", "myocardial", "oxygen", "demand", ",", "and", "it", "exhibits", "an", "important", "dose-response", "effect", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [10, 11]}}
{"token": ["C0054836#ent", "<e1>", "has", "been", "shown", "to", "improve", "exercise", "tolerance", "patients", "with", "C0002962#ent", "<e2>", "reduce", "the", "occurrence", "of", "episodes", "of", "silent", "myocardial", "ischaemia", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [11, 12]}}
{"token": ["C0244404#ent", "<e1>", "plus", "TPTD", "at", "both", "doses", "had", "C0059735#ent", "<e2>", "surfaces", "that", "were", "significantly", "less", "than", "Ovx", "but", "not", "different", "from", "sham", "or", "Ral", "alone", "."], "h": {"id": "C0244404", "name": "C0244404#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [8, 9]}}
{"token": ["These", "results", "demonstrate", "that", "the", "interactions", "of", "C1706331#ent", "<e1>", "and", "VLA-4/VLA-5", "transmit", "the", "growth", "signals", "are", "mediated", "through", "C0282625#ent", "<e2>", "the", "MAPK", "cascade", "Nalm-6", "cells", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [18, 19]}}
{"token": ["The", "C0018824#ent", "<e1>", "associated", "with", "exposure", "to", "cabergoline", "in", "common", "endocrine", "conditions", "such", "as", "C0268528#ent", "<e2>", "is", "unknown", "."], "h": {"id": "C0018824", "name": "C0018824#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [14, 15]}}
{"token": ["On", "the", "other", "hand", ",", "31", "and", "30", "were", "effective", "in", "antagonizing", "the", "AII-induced", "contraction", "of", "C0525678#ent", "<e1>", "and", "rise", "in", "C1419339#ent", "<e2>", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419339", "name": "C1419339#ent", "pos": [21, 22]}}
{"token": ["In", "particular", ",", "we", "analyzed", "biosynthesis", ",", "secretion", ",", "and", "activity", "of", "renin", "and", "other", "components", "of", "the", "C0525678#ent", "<e1>", "in", "mice", "lacking", "C1419339#ent", "<e2>", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1419339", "name": "C1419339#ent", "pos": [23, 24]}}
{"token": ["The", "rsf1", "mutant", "has", "C2987364#ent", "<e1>", "levels", "of", "phyA", "suggesting", "that", "C1708266#ent", "<e2>", "is", "required", "for", "phyA", "signaling", "than", "phyA", "stability", "or", "biosynthesis", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1708266", "name": "C1708266#ent", "pos": [11, 12]}}
{"token": ["Protein-protein", "interactions", "critical", "for", "efficient", "signalling", "from", "JNK", "to", "multiple", "targets", ";", "through", "a", "screen", "for", "C1423524#ent", "<e1>", "we", "identified", "a", "novel", "JNK-interacting", "protein", "Sab", "(", "C1420024#ent", "<e2>", ")", "."], "h": {"id": "C1423524", "name": "C1423524#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420024", "name": "C1420024#ent", "pos": [26, 27]}}
{"token": ["C0017083#ent", "<e1>", "isolated", "from", "tumor", "cells", "collagen-stimulated", "platelet", "aggregation", "C2744579#ent", "<e2>", "secretion", "and", "enhance", "platelet", "adhesion", "immobilized", "collagen", "."], "h": {"id": "C0017083", "name": "C0017083#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [9, 10]}}
{"token": ["The", "drugs", "used", "were", "siguazodan", ",", "rolipram", "and", "C0065432#ent", "<e1>", ",", "which", "specifically", "inhibit", "C1849508#ent", "<e2>", "types", ",", "III", ",", "IV", "and", "V", ",", "respectively", "."], "h": {"id": "C0065432", "name": "C0065432#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1849508", "name": "C1849508#ent", "pos": [14, 15]}}
{"token": ["Post-insulin", "receptor", "signal", "transduction", "mediated", "by", "a", "cascade", "of", "seryl/threonyl", "protein", "kinases", "which", "includes", "a", "family", "of", "C1979930#ent", "<e1>", "MAP", ")", "kinases", ",", "C0073337#ent", "<e2>", "and", "casein", "kinase-2"], "h": {"id": "C1979930", "name": "C1979930#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0073337", "name": "C0073337#ent", "pos": [23, 24]}}
{"token": ["It", "has", "been", "known", "that", "both", "C1979930#ent", "<e1>", "MAP", ")", "kinase", "and", "C0073337#ent", "<e2>", "be", "activated", "by", "many", "kinds", "of", "growth", "factors"], "h": {"id": "C1979930", "name": "C1979930#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0073337", "name": "C0073337#ent", "pos": [12, 13]}}
{"token": ["The", "determined", "reactive", "site", "loop", "domain", "hippocampus", "C3890007#ent", "<e1>", "will", "allow", "prediction", "of", "potential", "target", "C0030940#ent", "<e2>", "inhibited", "by", "C3890007#ent", "<e1>", "in", "AD", "."], "h": {"id": "C3890007", "name": "C3890007#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [15, 16]}}
{"token": ["The", "AM", "and", "Pit", "isoforms", "C3890007#ent", "<e1>", "may", "regulate", "novel", "target", "C0030940#ent", "<e2>", "involved", "in", "neuroendocrine", "function"], "h": {"id": "C3890007", "name": "C3890007#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [11, 12]}}
{"token": ["Hepatocellular", "carcinoma", "occurs", "in", "patients", "with", "C1623038#ent", "<e1>", "and", "is", "rarely", "associated", "with", "C0751911#ent", "<e2>"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751911", "name": "C0751911#ent", "pos": [13, 14]}}
{"token": ["To", "clarify", "whether", "early", "treatment", "C0400914#ent", "<e1>", "similarly", "efficient", "in", "human", "immunodeficiency", "virus", "C0019693#ent", "<e2>", ")", "positive", "patients", ",", "we", "conducted", "a", "retrospective", "survey", "HIV-positive", "patients", "with", "acute", "HCV", "infection", "."], "h": {"id": "C0400914", "name": "C0400914#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [13, 14]}}
{"token": ["L-glutamate", "and", "several", "C0027203#ent", "<e1>", "forms", "resulting", "from", "the", "weak", "binding", "to", "C1883620#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1883620", "name": "C1883620#ent", "pos": [12, 13]}}
{"token": ["In", "presence", "of", "ovarian", "steroids", "C1513344#ent", "<e1>", "p38", "and", "ERK", "pathways", "stimulated", "C1710291#ent", "<e2>", "but", "inhibited", "TGF-beta2", "expression", "."], "h": {"id": "C1513344", "name": "C1513344#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1710291", "name": "C1710291#ent", "pos": [12, 13]}}
{"token": ["Shrimp", "and", "crab", "shell", "powder", "(", "SCSP", ")", ",", "prepared", "by", "treating", "shellfish", "processing", "waste", "with", "C0242301#ent", "<e1>", "and", "crushing", ",", "was", "used", "as", "a", "substrate", "for", "C1875400#ent", "<e2>", "chitinolytic", "microorganisms"], "h": {"id": "C0242301", "name": "C0242301#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [27, 28]}}
{"token": ["This", "paper", "will", "review", "the", "three", "C0042769#ent", "<e1>", "emphasis", "on", "C0242994#ent", "<e2>", ",", "its", "diagnosis", ",", "treatment", ",", "and", "prevention", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0242994", "name": "C0242994#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "the", "decrease", "in", "C0596123#ent", "<e1>", "not", "be", "attributed", "to", "depression", "of", "transcription", "of", "the", "C0596123#ent", "<e1>", "TCDD", "."], "h": {"id": "C0596123", "name": "C0596123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0596123", "name": "C0596123#ent", "pos": [5, 6]}}
{"token": ["We", "therefore", "conclude", "that", "the", "C0596123#ent", "<e1>", "and", "Asp1", "loci", "nonallelic", "and", "that", "the", "C0596123#ent", "<e1>", "excluded", "as", "a", "candidate", "for", "Asp1", "."], "h": {"id": "C0596123", "name": "C0596123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0596123", "name": "C0596123#ent", "pos": [5, 6]}}
{"token": ["An", "C3659502#ent", "<e1>", "is", "closely", "associated", "with", "C0018969#ent", "<e2>", "a", "kind", "of", "multienzyme-complex", "."], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018969", "name": "C0018969#ent", "pos": [7, 8]}}
{"token": ["To", "compare", "the", "efficacy", "and", "cost", "implications", "of", "the", "use", "of", "the", "intraocular", "pressure-lowering", "prostaglandin", "analogues", "bimatoprost", ",", "C0937916#ent", "<e1>", ",", "and", "latanoprost", "as", "fixed-combination", "therapies", "timolol", ",", "a", "C0001644#ent", "<e2>"], "h": {"id": "C0937916", "name": "C0937916#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [29, 30]}}
{"token": ["Our", "results", "provide", "valuable", "information", "for", "the", "study", "of", "C1279412#ent", "<e1>", "paramyotonia", "congenita", "two", "inherited", "C0042075#ent", "<e2>", "are", "caused", "by", "point", "mutations", "within", "this", "gene", "."], "h": {"id": "C1279412", "name": "C1279412#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [15, 16]}}
{"token": ["C0008412#ent", "<e1>", "results", "in", "C2711227#ent", "<e2>"], "h": {"id": "C0008412", "name": "C0008412#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [4, 5]}}
{"token": ["We", "identified", "the", "expression", "of", "the", "alternative", "cAMP", "target", ",", "C1538124#ent", "<e1>", "activated", "by", "cAMP-1", "(", "C1419227#ent", "<e2>", ")", ",", "in", "human", "and", "rat", "AMs", "."], "h": {"id": "C1538124", "name": "C1538124#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419227", "name": "C1419227#ent", "pos": [16, 17]}}
{"token": ["The", "prion", "protein", "PrP", ")", "is", "found", "in", "amyloid", "of", "animals", "with", "C0036457#ent", "<e1>", "and", "humans", "with", "Creutzfeldt-Jakob", "disease", "the", "C2362547#ent", "<e2>", "present", "in", "amyloid", "deposits", "Alzheimer", "disease", "Down", "syndrome", "patients", "."], "h": {"id": "C0036457", "name": "C0036457#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2362547", "name": "C2362547#ent", "pos": [20, 21]}}
{"token": ["C0059735#ent", "<e1>", "EROD", ")", "and", "C0005096#ent", "<e2>", "(", "BPND", ")", "were", "selectively", "induced", "by", "BNF", "and", "PB", ",", "respectively", "."], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005096", "name": "C0005096#ent", "pos": [5, 6]}}
{"token": ["In", "parallel", ",", "in", "the", "case", "of", "3-methylcholantrene", "induction", "benz(a)pyrene", "hydroxylase", "C0059735#ent", "<e1>", "increase", ";", "phenobarbital", "induction", "causes", "a", "rise", "in", "the", "C0005096#ent", "<e2>", "and", "benz(a)pyrene", "hydroxylase", "activities", "."], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0005096", "name": "C0005096#ent", "pos": [22, 23]}}
{"token": ["Treatment", "with", "3-methylcholanthrene", "significantly", "induced", "the", "activities", "of", "arylhydrocarbon", "hydroxylase", "7-ethoxyresorufin", "O-deethylase", "C0059735#ent", "<e1>", "whereas", "those", "of", "ethoxycoumarin", "O-deethylase", "C0005096#ent", "<e2>", "erythromycin", "N-demethylase", "and", "testosterone", "hydroxylases", "not", "affected", "."], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0005096", "name": "C0005096#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", "we", "investigated", "glass", "spheres", "(", "C2347435#ent", "<e1>", ")", "as", "an", "alternative", "injectable", "substance", "to", "correct", "vesicoureteral", "reflux", "C0042580#ent", "<e2>", ")", "in", "an", "animal", "model"], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042580", "name": "C0042580#ent", "pos": [20, 21]}}
{"token": ["This", "value", "was", "unaffected", "by", "amiloride", "but", "decreased", "to", "7.01", "in", "the", "presence", "of", "NEM", ",", "suggesting", "active", "C0379099#ent", "<e1>", "and", "inactive", "Na(+)-H+", "antiport", "at", "steady-state", "C2975867#ent", "<e2>", "."], "h": {"id": "C0379099", "name": "C0379099#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2975867", "name": "C2975867#ent", "pos": [26, 27]}}
{"token": ["Two", "exacerbations", "of", "C0004096#ent", "<e1>", "during", "budesonide", "treatment", "and", "none", "during", "C0082607#ent", "<e2>", "treatment", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0082607", "name": "C0082607#ent", "pos": [11, 12]}}
{"token": ["Hepatic", "Nuclear", "Factor", "1", "C1420631#ent", "<e1>", ",", "also", "referred", "to", "as", "LFB1", ",", "C1413160#ent", "<e2>", "or", "APF", ")", "is", "a", "liver-specific", "transcription", "factor", "for", "the", "expression", "of", "many", "hepatocyte", "specific", "genes", "."], "h": {"id": "C1420631", "name": "C1420631#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413160", "name": "C1413160#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "present", "crystal", "structures", "human", "C1142644#ent", "<e1>", "in", "complex", "with", "two", "well", "characterized", "drugs", ":", "C0022625#ent", "<e2>", "and", "erythromycin", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [17, 18]}}
{"token": ["In", "a", "rescue", "assay", "we", "demonstrate", "that", "C0040663#ent", "<e1>", "Oct4", "and", "Sox2", "fusion", "proteins", "compensate", "knockdown", "of", "C1418768#ent", "<e2>", "and", "Sox2", ",", "respectively", "."], "h": {"id": "C0040663", "name": "C0040663#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418768", "name": "C1418768#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "the", "high", "incidence", "of", "C0042510#ent", "<e1>", "which", "is", "related", "to", "up-regulation", "of", "inflammatory", "factors", "the", "C0878544#ent", "<e2>", "significantly", "suppressed", "by", "selective", "ET(A)R", "blockade", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0878544", "name": "C0878544#ent", "pos": [19, 20]}}
{"token": ["We", "report", "on", "the", "initiation", "of", "ventricular", "fibrillation", "C0042510#ent", "<e1>", ")", "storm", "in", "patients", "with", "C0878544#ent", "<e2>", "ICM", ")", "and", "the", "results", "of", "targeted", "ablation", "to", "treat", "C0042510#ent", "<e1>", "storm", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0878544", "name": "C0878544#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "this", "study", "shows", "that", "C0066673#ent", "<e1>", "has", "a", "concerted", "influence", "on", "multiple", "elements", "the", "C1367469#ent", "<e2>", "axis", "manifesting", "functionally", "as", "a", "reduced", "neuroendocrine", "responsiveness", "stress", "."], "h": {"id": "C0066673", "name": "C0066673#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [17, 18]}}
{"token": ["Initial", "velocity", "and", "product", "inhibition", "kinetics", "of", "the", "C0671924#ent", "<e1>", "EC", "2.3.1.48", ")", "reaction", "indicate", "that", "the", "rat", "C0023899#ent", "<e2>", "nuclear", "enzyme", "under", "a", "rapid", "equilibrium", "ordered", "bireactant", "mechanism", "."], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}}
{"token": ["Fixation", "of", "AD", "tissue", "with", "periodate-lysine-paraformaldehyde", "(", "C1418882#ent", "<e1>", ")", "preserves", "axonal", "C1446659#ent", "<e2>", "antigenicity", "."], "h": {"id": "C1418882", "name": "C1418882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1446659", "name": "C1446659#ent", "pos": [12, 13]}}
{"token": ["Recently", ",", "the", "use", "of", "C0358591#ent", "<e1>", "PPIs", ")", "has", "been", "associated", "with", "increased", "risk", "of", "C1535939#ent", "<e2>", "."], "h": {"id": "C0358591", "name": "C0358591#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [16, 17]}}
{"token": ["The", "genes", "coding", "for", "C3272408#ent", "<e1>", "and", "DP2", ",", "the", "subunits", "of", "this", "C0082328#ent", "<e2>", "are", "highly", "conserved", "in", "the", "Euryarchaeota", "."], "h": {"id": "C3272408", "name": "C3272408#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0082328", "name": "C0082328#ent", "pos": [13, 14]}}
{"token": ["C4284306#ent", "<e1>", "photolysis", "at", "266", "nm", "of", "C0047645#ent", "<e2>", "and", "N-acetyl-3-nitrotyrosine", "ethyl", "ester", "generates", "an", "oxidizing", "species", "which", "shows", "all", "of", "the", "characteristics", "of", "a", "hydroxyl", "radical"], "h": {"id": "C4284306", "name": "C4284306#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0047645", "name": "C0047645#ent", "pos": [7, 8]}}
{"token": ["Residues", "127", "-", "193", "constitute", "the", "primary", "interaction", "region", "on", "C1423613#ent", "<e1>", "to", "which", "C0079471#ent", "<e2>", "binds", ",", "while", "C1423613#ent", "<e1>", "binds", "to", "the", "C-terminal", "26", "residues", "of", "C0079471#ent", "<e2>", "."], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1423613", "name": "C1423613#ent", "pos": [10, 11]}}
{"token": ["Using", "a", "yeast", "two-hybrid", "screening", "technique", "the", "C1423613#ent", "<e1>", "human", "DNA", "polymerase", "delta", "pol", "delta", "as", "a", "bait", ",", "C0079471#ent", "<e2>", "was", "found", "to", "interact", "with", "the", "C1423613#ent", "<e1>", "pol", "delta"], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1423613", "name": "C1423613#ent", "pos": [7, 8]}}
{"token": ["Induction", "of", "apoptosis", "has", "been", "linked", "to", "unscheduled", "up-regulation", "of", "C1332694#ent", "<e1>", "activation", "of", "C1540306#ent", "<e2>", "activity", "due", "to", "cleavage", "of", "cyclin-dependent", "kinase", "inhibitors", "caspases", "."], "h": {"id": "C1332694", "name": "C1332694#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1540306", "name": "C1540306#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "the", "local", "administration", "C1259477#ent", "<e1>", "may", "be", "useful", "for", "treating", "C0085096#ent", "<e2>"], "h": {"id": "C1259477", "name": "C1259477#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [14, 15]}}
{"token": ["The", "protective", "effect", "C1259477#ent", "<e1>", ",", "a", "specific", "Galphaq/11", "inhibitor", ",", "on", "C0085096#ent", "<e2>", "rats", "was", "compared", "with", "those", "of", "prostaglandin", "E1", "PGE1", ")", ",", "beraprost", ",", "and", "clopidogrel", "."], "h": {"id": "C1259477", "name": "C1259477#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [12, 13]}}
{"token": ["We", "further", "show", "that", "the", "meningococcal", "fpg", "co-transcribed", "with", "nlaA", ",", "encoding", "a", "C0126485#ent", "<e1>", "and", "suggest", "that", "the", "C1333237#ent", "<e2>", "enzyme", "may", "be", "involved", "in", "the", "regulation", "of", "nlaA", "or", "its", "gene", "product"], "h": {"id": "C0126485", "name": "C0126485#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [19, 20]}}
{"token": ["Neither", "the", "Ca2", "+", "-activated", "C0033607#ent", "<e1>", "leupeptin", ",", "nor", "the", "antioxidants", ",", "alpha-tocopherol", "or", "C1511755#ent", "<e2>", ",", "were", "able", "to", "prevent", "either", "VP-induced", "plasma", "membrane", "blebbing", "or", "canalicular", "dysfunction"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1511755", "name": "C1511755#ent", "pos": [15, 16]}}
{"token": ["Calcium-oxalate", "(", "CaOx", ")", "deposition", "and", "systemic", "oxalosis", "uncommon", "in", "children", "with", "C1561643#ent", "<e1>", "CRI", ")", ",", "but", "frequent", "in", "children", "with", "C1412290#ent", "<e2>", "PH-1", ")", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412290", "name": "C1412290#ent", "pos": [22, 23]}}
{"token": ["Chromosomal", "abnormalities", "lead", "to", "a", "severe", "C0037769#ent", "<e1>", "poor", "prognosis", "neurological", "outcome", "persistent", "severe", "C0014544#ent", "<e2>", ",", "mental", "retardation", "and", "behavioral", "disturbances", "."], "h": {"id": "C0037769", "name": "C0037769#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [14, 15]}}
{"token": ["C0025153#ent", "<e1>", "is", "the", "main", "C0003374#ent", "<e2>", "used", "for", "treatment", "of", "falciparum", "malaria", "patients", "at", "the", "malaria", "clinics", "in", "Thailand", "."], "h": {"id": "C0025153", "name": "C0025153#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [5, 6]}}
{"token": ["A", "correlation", "between", "reduced", "expression", "of", "C1333655#ent", "<e1>", "and", "increased", "resistance", "to", "C0012920#ent", "<e2>", "topoisomerase", "II", "inhibitors", "a", "variety", "of", "human", "cell", "lines", "also", "found", "."], "h": {"id": "C1333655", "name": "C1333655#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012920", "name": "C0012920#ent", "pos": [12, 13]}}
{"token": ["C1259016#ent", "<e1>", "inhibits", "both", "the", "phosphorylation", "of", "cofilin", "by", "C0294273#ent", "<e2>", "and", "LIMK1-induced", "cytokinesis", "defects", "."], "h": {"id": "C1259016", "name": "C1259016#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0294273", "name": "C0294273#ent", "pos": [9, 10]}}
{"token": ["A", "second", "TSP1", "receptor", ",", "CD47", ",", "was", "not", "required", "for", "some", "stimulatory", "responses", "to", "C1336626#ent", "<e1>", "but", "played", "a", "significant", "role", "in", "its", "C1516869#ent", "<e2>", "antiproliferative", "activities"], "h": {"id": "C1336626", "name": "C1336626#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [24, 25]}}
{"token": ["We", "previously", "reported", "that", "this", "effect", "of", "C1334081#ent", "<e1>", "was", "blocked", "by", "a", "putative", "phospholipase", "A2", "C1418617#ent", "<e2>", ")", "inhibitor", ",", "ONO-RS-082", "(", "5", "microM", ")", "."], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418617", "name": "C1418617#ent", "pos": [16, 17]}}
{"token": ["As", "to", "the", "first", ",", "we", "must", "underline", "the", "C0267853#ent", "<e1>", "more", "often", "by", "cytomegalovirus", ",", "the", "C0566602#ent", "<e2>", "anorectal", "sepsis", "."], "h": {"id": "C0267853", "name": "C0267853#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [17, 18]}}
{"token": ["It", "also", "points", "to", "the", "possibilities", "of", "finding", "new", "molecular", "modifications", "could", "lead", "to", "C3541353#ent", "<e1>", "with", "activity", "both", "against", "human", "immunodeficiency", "viruses", "C0019693#ent", "<e2>", ")", "and", "herpesviruses", "."], "h": {"id": "C3541353", "name": "C3541353#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [23, 24]}}
{"token": ["The", "C3536869#ent", "<e1>", "component", "of", "C3541980#ent", "<e2>", "consists", "of", "a", "single", "DS", "chain", "attached", "to", "serine", "137", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3541980", "name": "C3541980#ent", "pos": [5, 6]}}
{"token": ["A", "boy", "with", "an", "unspecific", "symptomatology", "consisting", "of", "mental", "retardation", "strabismus", ",", "hypotonia", "and", "C0004134#ent", "<e1>", "diagnosed", "with", "a", "congenital", "disorder", "glycosylation", "(", "C2677590#ent", "<e2>", ")", "."], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C2677590", "name": "C2677590#ent", "pos": [23, 24]}}
{"token": ["A", "case", "of", "solar", "retinitis", "presented", "in", "which", "treatment", "with", "C3539185#ent", "<e1>", "lessened", "the", "C0242420#ent", "<e2>", "the", "patient", "suffered", "a", "bilateral", "central", "scotoma", "vision", "reduced", "to", "the", "20/40", "level", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242420", "name": "C0242420#ent", "pos": [14, 15]}}
{"token": ["The", "influence", "of", "C0036079#ent", "<e1>", "ASA", ")", "derivatives", "with", "C0914069#ent", "<e2>", "PAF", ")", "lipid", "analogs", "PAF-induced", "human", "platelet", "aggregation", "been", "studied", "."], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0914069", "name": "C0914069#ent", "pos": [9, 10]}}
{"token": ["In", "addition", "to", "elevated", "C0812281#ent", "<e1>", "accumulation", ",", "hepatocyte", "death", "augmented", "by", "loss", "of", "either", "C0663914#ent", "<e2>", "p38", "alpha", "was", "associated", "with", "release", "of", "IL-1", "alpha"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0663914", "name": "C0663914#ent", "pos": [15, 16]}}
{"token": ["We", "propose", "that", "seprase/FAP", "alpha", "and", "C2984141#ent", "<e1>", "represent", "a", "new", "subfamily", "of", "C1622401#ent", "<e2>", "SIMP", ")", "."], "h": {"id": "C2984141", "name": "C2984141#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1622401", "name": "C1622401#ent", "pos": [13, 14]}}
{"token": ["The", "higher", "C0669365#ent", "<e1>", "expression", "of", "HSP70", "and", "C3538704#ent", "<e2>", "could", "contribute", "to", "this", "resistance", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [8, 9]}}
{"token": ["C0669365#ent", "<e1>", "expressed", "heat-shock", "proteins", "the", "C3538704#ent", "<e2>", "and", "hsp70", "families", ",", "classified", "as", "'", "molecular", "chaperones", ",", "have", "important", "functions", "in", "the", "folding", "and", "intracellular", "sorting", "of", "newly-synthesized", "proteins", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [6, 7]}}
{"token": ["Estimation", "of", "the", "concentration", "of", "C1413029#ent", "<e1>", ",", "C-reactive", "protein", "CRP", ")", "and", "alpha1-antitrypsin", "in", "forty", "sera", "from", "patients", "with", "C0157770#ent", "<e2>", "recurrent", "oral", "ulcers", "significantly", "increased", "amounts", "of", "C1413029#ent", "<e1>", "and", "CRP", "in", "C0157770#ent", "<e2>"], "h": {"id": "C1413029", "name": "C1413029#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0157770", "name": "C0157770#ent", "pos": [20, 21]}}
{"token": ["Deletion", "analysis", "C1332823#ent", "<e1>", "promoter", "identified", "a", "seven-base", "pair", "p53-repressor", "element", "C1512488#ent", "<e2>", "to", "cyclic", "AMP/AP-1", "response", "(", "CRE/AP-1", ")", "element", "."], "h": {"id": "C1332823", "name": "C1332823#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}}
{"token": ["The", "adrenergic", "system", "been", "suggested", "to", "play", "a", "role", "in", "C0040517#ent", "<e1>", "based", "on", "the", "reduction", "of", "symptoms", "with", "the", "adrenergic", "receptor", "agonists", "C0009014#ent", "<e2>", "and", "guanfacine", "."], "h": {"id": "C0040517", "name": "C0040517#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [23, 24]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "determine", "the", "incidence", "of", "the", "in", "vivo", "induction", "of", "phase", "II", "C3541394#ent", "<e1>", "by", "individual", "C0175699#ent", "<e2>", "on", "the", "genotoxicity", "of", "several", "carcinogens", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0175699", "name": "C0175699#ent", "pos": [21, 22]}}
{"token": ["Interaction", "of", "CD40", "with", "its", "ligand", "(", "C1706005#ent", "<e1>", ")", "can", "induce", "CD40-bearing", "C0033036#ent", "<e2>", "to", "express", "immune", "stimulatory", "accessory", "molecules", "facilitate", "immune", "recognition"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [13, 14]}}
{"token": ["The", "phosphorylation", "and", "activation", "of", "C1418599#ent", "<e1>", "correlated", "with", "C2986464#ent", "<e2>", "stimulated", "by", "CCK-8", "or", "CCh", ",", "as", "measured", "by", "NF-kappaB", "DNA", "binding"], "h": {"id": "C1418599", "name": "C1418599#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [9, 10]}}
{"token": ["The", "acetylation", "of", "ERalpha", "by", "p300", "is", "reversed", "by", "native", "cellular", "deacetylases", "including", "trichostatin", "A-sensitive", "enzymes", "(", "i.e.", "class", "I", "C1333261#ent", "<e1>", "and", "nicotinamide", "adenine", "enzymes", "(", "i.e.", "class", "III", "deacetylases", "such", "as", "C2720167#ent", "<e2>", "."], "h": {"id": "C1333261", "name": "C1333261#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2720167", "name": "C2720167#ent", "pos": [33, 34]}}
{"token": ["The", "acetylation", "of", "ERalpha", "by", "p300", "is", "reversed", "by", "native", "cellular", "deacetylases", "including", "trichostatin", "A-sensitive", "enzymes", "(", "i.e.", "class", "I", "II", "deacetylases", "and", "nicotinamide", "adenine", "enzymes", "(", "i.e.", "C1333261#ent", "<e1>", "such", "as", "C2720167#ent", "<e2>", "."], "h": {"id": "C1333261", "name": "C1333261#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C2720167", "name": "C2720167#ent", "pos": [32, 33]}}
{"token": ["If", "this", "strategy", "is", "adopted", ",", "C0078839#ent", "<e1>", "is", "a", "safe", "alternative", "to", "benzodiazpine", "hypnotics", "and", "C0078847#ent", "<e2>", "who", "do", "show", "significant", "driving", "impairment", "the", "morning", "following", "bedtime", "administration", "."], "h": {"id": "C0078839", "name": "C0078839#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0078847", "name": "C0078847#ent", "pos": [16, 17]}}
{"token": ["This", "review", "aims", "to", "summarise", "the", "published", "clinical", "drug", "interaction", "studies", "involving", "C0078839#ent", "<e1>", ",", "zaleplon", "and", "C0078847#ent", "<e2>", "."], "h": {"id": "C0078839", "name": "C0078839#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0078847", "name": "C0078847#ent", "pos": [17, 18]}}
{"token": ["Alpidem", "(", "10(-6)-10(-5", ")", "M", ")", ",", "C0078839#ent", "<e1>", "(", "10(-6)-10(-4", ")", "M", ")", "and", "C0078847#ent", "<e2>", "(", "10(-6)-10(-4", ")", "M", ")", "were", "without", "any", "significant", "effect", "on", "the", "adenosine", "concentration-response", "curves"], "h": {"id": "C0078839", "name": "C0078839#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0078847", "name": "C0078847#ent", "pos": [15, 16]}}
{"token": ["A", "case", "report", "a", "34-year-old", "black", "man", "C0013312#ent", "<e1>", "his", "left", "small", "finger", "review", "of", "the", "literature", "of", "C4082974#ent", "<e2>", "the", "black", "population", "presented", "."], "h": {"id": "C0013312", "name": "C0013312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4082974", "name": "C4082974#ent", "pos": [18, 19]}}
{"token": ["C0017337#ent", "<e1>", "with", "homology", "to", "the", "C0017339#ent", "<e2>", "which", "encodes", "a", "protein", "involved", "in", "post-replication", "DNA", "mismatch", "repair", "are", "known", "in", "several", "organisms", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017339", "name": "C0017339#ent", "pos": [6, 7]}}
{"token": ["We", "inserted", "C0017337#ent", "<e1>", "or", "gene", "segments", "that", "code", "for", "the", "bacterial", "chloramphenicol", "acetyltransferase", "the", "C0017339#ent", "<e2>", "resistance", "against", "hygromycin", ",", "and", "the", "ORF", "E7", "of", "the", "human", "papillomavirus", "type", "18", "these", "vectors", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017339", "name": "C0017339#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "39-", ",", "23-", ",", "and", "C1332669#ent", "<e1>", "be", "used", "in", "an", "IgM", "immunoassay", "diagnosis", "of", "C1705360#ent", "<e2>", "."], "h": {"id": "C1332669", "name": "C1332669#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [19, 20]}}
{"token": ["We", "report", "a", "clinical", "case", "a", "patient", "with", "a", "side-to-side", "choledocoduodenostomy", "because", "of", "C0701818#ent", "<e1>", "who", "developed", "a", "C0524784#ent", "<e2>"], "h": {"id": "C0701818", "name": "C0701818#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524784", "name": "C0524784#ent", "pos": [18, 19]}}
{"token": ["The", "reduced", "C1420747#ent", "<e1>", "expression", "was", "confirmed", "by", "an", "absence", "of", "a", "detectable", "C1522555#ent", "<e2>", "western", "blot", "H9-ddC", "cells", "."], "h": {"id": "C1420747", "name": "C1420747#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1522555", "name": "C1522555#ent", "pos": [13, 14]}}
{"token": ["In", "the", "eubacterium", "Escherichia", "coli", "genes", "for", "the", "C1335636#ent", "<e1>", "S9", "form", "an", "C0022895#ent", "<e2>", "consisting", "of", "two", "genes", "."], "h": {"id": "C1335636", "name": "C1335636#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [13, 14]}}
{"token": ["C0012227#ent", "<e1>", "a", "new", "fluorinated", "C3536709#ent", "<e2>", "for", "tropical", "use", "was", "applied", "in", "52", "patients", "suffering", "of", "diverse", "inflammatory", "dermatosis"], "h": {"id": "C0012227", "name": "C0012227#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [5, 6]}}
{"token": ["In", "addition", ",", "the", "relationship", "between", "C1420314#ent", "<e1>", "and", "severity", "of", "C0577631#ent", "<e2>", "studied", "in", "a", "subgroup", "of", "105", "patients", "."], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0577631", "name": "C0577631#ent", "pos": [11, 12]}}
{"token": ["Accumulation", "of", "the", "azole", "fungicide", "by", "the", "overexpression", "mutants", "was", "lower", "as", "compared", "to", "the", "parental", "C1875400#ent", "<e1>", ",", "demonstrating", "that", "C1705843#ent", "<e2>", "acts", "by", "preventing", "intracellular", "accumulation", "of", "the", "toxicant", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705843", "name": "C1705843#ent", "pos": [21, 22]}}
{"token": ["The", "effects", "of", "C1161352#ent", "<e1>", "and", "cimetropium", "bromide", "a", "new", "C0003385#ent", "<e2>", "strong", "spasmolytic", "properties", ",", "were", "studied", "on", "human", "esophageal", "motility"], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003385", "name": "C0003385#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "demonstrate", "that", "murine", "mast", "cell", "are", "exacerbated", "in", "vitro", "in", "vivo", "autocrine", "signals", "G", "protein-coupled", "receptors", "C3890198#ent", "<e1>", ")", "and", "require", "functional", "phosphoinositide", "3-kinase", "gamma", "C2713509#ent", "<e2>", ")", "."], "h": {"id": "C3890198", "name": "C3890198#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [27, 28]}}
{"token": ["Ibandronate", "is", "an", "effective", "and", "generally", "well", "tolerated", "bisphosphonate", "that", "offers", "an", "alternative", "to", "other", "C3541401#ent", "<e1>", "as", "a", "first-line", "treatment", "C0029458#ent", "<e2>"], "h": {"id": "C3541401", "name": "C3541401#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [21, 22]}}
{"token": ["The", "chimera", "was", "fully", "functional", ",", "and", "associated", "with", "phosphorylated", "phospholipase", "C", "gamma", "PLC", "gamma", ",", "C1419278#ent", "<e1>", "GAP", ")", "and", "the", "non-catalytic", "subunit", "C0089793#ent", "<e2>", ",", "p85", ",", "in", "a", "ligand-dependent", "manner", "."], "h": {"id": "C1419278", "name": "C1419278#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [24, 25]}}
{"token": ["In", "contrast", ",", "during", "senescence", "of", "detached", "leaves", ",", "both", "EP1", "and", "C4049874#ent", "<e1>", "activities", "increased", "and", "four", "new", "species", "of", "C0030940#ent", "<e2>", "appeared", "."], "h": {"id": "C4049874", "name": "C4049874#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [21, 22]}}
{"token": ["Cycloheximide", "and", "kinetin", "both", "inhibited", "the", "increase", "of", "EP1", ",", "C4049874#ent", "<e1>", ",", "and", "the", "induction", "of", "the", "four", "new", "C0030940#ent", "<e2>", ";", "chloramphenicol", "had", "no", "effect"], "h": {"id": "C4049874", "name": "C4049874#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [20, 21]}}
{"token": ["This", "suggested", "epigenetic", "reprogramming", "such", "as", "upregulation", "of", "C2718309#ent", "<e1>", "HDAC1", ")", "gene", "and", "downregulation", "of", "its", "target", "C1417679#ent", "<e2>", "."], "h": {"id": "C2718309", "name": "C2718309#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["The", "C2718309#ent", "<e1>", "be", "targeted", "to", "certain", "C1417679#ent", "<e2>", "through", "its", "interaction", "with", "DNA-binding", "regulatory", "proteins"], "h": {"id": "C2718309", "name": "C2718309#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}}
{"token": ["However", ",", "whether", "stress-corrected", "C0796033#ent", "<e1>", "parallels", "LV", "diastolic", "filling", "better", "than", "C0059037#ent", "<e2>", "does", "remains", "uncertain", "."], "h": {"id": "C0796033", "name": "C0796033#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [12, 13]}}
{"token": ["For", "C0027583#ent", "<e1>", "Mebendazole", "(", "Vermox", ",", "Surfont", ")", ",", "C0034237#ent", "<e2>", "(", "Helmex", ")", ",", "Pyrviniumembonate", "(", "Molevac", ",", "Pyrcon", ")", "are", "effective", "."], "h": {"id": "C0027583", "name": "C0027583#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034237", "name": "C0034237#ent", "pos": [10, 11]}}
{"token": ["In", "this", "paper", "we", "have", "applied", "the", "matrix", "method", "calculating", "spectacle", "magnification", "SM", ")", "and", "relative", "spectacle", "magnification", "C3828360#ent", "<e1>", ")", "for", "myopic", "C0235267#ent", "<e2>", "corrected", "with", "ophthalmic", "lenses", "OLs", ")", "."], "h": {"id": "C3828360", "name": "C3828360#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [23, 24]}}
{"token": ["Chlamydia", "trachomatis", "known", "to", "cause", "C3714636#ent", "<e1>", "conjunctivitis", "and", "is", "a", "suspected", "cause", "of", "C2827407#ent", "<e2>", "gastroenteritis", "."], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2827407", "name": "C2827407#ent", "pos": [14, 15]}}
{"token": ["To", "evaluate", "the", "effects", "of", "long-term", "treatment", "with", "C0075616#ent", "<e1>", "on", "the", "progression", "of", "C0011884#ent", "<e2>", "DR", ")", "."], "h": {"id": "C0075616", "name": "C0075616#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [14, 15]}}
{"token": ["A", "genetic", "screen", "identify", "termination", "factors", "an", "C0002085#ent", "<e1>", "that", "separated", "pausing/imprinting", "and", "termination", "functions", "C1537460#ent", "<e2>", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1537460", "name": "C1537460#ent", "pos": [15, 16]}}
{"token": ["The", "production", "of", "new", "C0009325#ent", "<e1>", "is", "taken", "to", "depend", "on", "the", "stretching", "of", "the", "C0519097#ent", "<e2>", "and", "the", "continuous", "remodeling", "the", "collagen", "fibers", "responsible", "for", "the", "aneurysm", "growth"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0519097", "name": "C0519097#ent", "pos": [15, 16]}}
{"token": ["The", "study", "of", "the", "distribution", "and", "synthetic", "regulation", "various", "types", "of", "C0009325#ent", "<e1>", "in", "the", "C0519097#ent", "<e2>", "be", "essential", "for", "understanding", "the", "formation", "of", "the", "C0519097#ent", "<e2>", "its", "protection", "against", "enlargement", "or", "rupture", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0519097", "name": "C0519097#ent", "pos": [15, 16]}}
{"token": ["Interaction", "was", "dependent", "on", "C1705001#ent", "<e1>", "autophosphorylation", "but", "C1426024#ent", "<e2>", "was", "not", "tyrosine", "phosphorylated", "by", "C1705001#ent", "<e1>", "."], "h": {"id": "C1705001", "name": "C1705001#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1426024", "name": "C1426024#ent", "pos": [8, 9]}}
{"token": ["Alterations", "in", "tissue", "content", "of", "fatty", "acid-transport", "proteins", "contribute", "to", "C0878544#ent", "<e1>", "as", "the", "C3534591#ent", "<e2>", "and", "cardiac", "hypertrophy", "failure", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C3534591", "name": "C3534591#ent", "pos": [14, 15]}}
{"token": ["C0878544#ent", "<e1>", "defined", "as", "ventricular", "dysfunction", "the", "C3534591#ent", "<e2>", "the", "absence", "of", "coronary", "artery", "disease"], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C3534591", "name": "C3534591#ent", "pos": [7, 8]}}
{"token": ["Verbena", "officinalis", "L.", "used", "in", "folk", "medicine", "the", "treatment", "of", "C0029877#ent", "<e1>", "skin", "burns", "abrasions", ",", "and", "C0038354#ent", "<e2>"], "h": {"id": "C0029877", "name": "C0029877#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038354", "name": "C0038354#ent", "pos": [17, 18]}}
{"token": ["Single", "fibre", "electromyography", "carried", "out", "in", "patients", "with", "polyneuropathy", "due", "to", "C0041948#ent", "<e1>", ",", "diabetes", ",", "and", "C0001962#ent", "<e2>", "."], "h": {"id": "C0041948", "name": "C0041948#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [17, 18]}}
{"token": ["Sequential", "studies", "C0019189#ent", "<e1>", "confirm", "the", "association", "of", "raised", "C3641673#ent", "<e2>", "levels", "with", "the", "active", "phase", "the", "illness", "."], "h": {"id": "C0019189", "name": "C0019189#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3641673", "name": "C3641673#ent", "pos": [9, 10]}}
{"token": ["Our", "aim", "was", "to", "compare", "infections", "in", "patients", "with", "RA", "under", "treatment", "with", "C0242708#ent", "<e1>", "DMARDs", ")", "and", "C0812246#ent", "<e2>", "antagonists", "in", "a", "university", "outpatient", "rheumatology", "clinic", "in", "Turkey", "."], "h": {"id": "C0242708", "name": "C0242708#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "patients", "with", "C0001403#ent", "<e1>", "a", "pattern", "of", "C0038317#ent", "<e2>", "excretion", "characterized", "by", "the", "absence", "of", "21-hydroxylated", "metabolites"], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [10, 11]}}
{"token": ["C0037549#ent", "<e1>", "has", "antiviral", "effects", "the", "result", "of", "its", "potent", "C0003402#ent", "<e2>"], "h": {"id": "C0037549", "name": "C0037549#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "cyotoxic/cytostatic", "effects", "of", "C0060061#ent", "<e1>", "were", "revealed", "by", "a", "decrease", "in", "the", "proliferative", "rate", "index", "C3539761#ent", "<e2>", ")", "and", "in", "the", "cytokinesis", "block", "proliferation", "index", "(", "CBPI", ")", "."], "h": {"id": "C0060061", "name": "C0060061#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539761", "name": "C3539761#ent", "pos": [18, 19]}}
{"token": ["Spontaneously", "hypercholesterolemic", "(", "C1705297#ent", "<e1>", ")", "rats", "exhibit", "hypercholesterolemia", ",", "proteinuria", "and", "C0178664#ent", "<e2>", "age", ",", "and", "they", "finally", "die", "as", "a", "result", "of", "renal", "failure"], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [12, 13]}}
{"token": ["Spontaneously", "hypercholesterolemic", "(", "C1705297#ent", "<e1>", ")", "rats", "develop", "hypercholesterolemia", "and", "C0178664#ent", "<e2>", "and", "have", "been", "thought", "to", "be", "a", "model", "of", "lipid-induced", "glomerular", "injury", "."], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [10, 11]}}
{"token": ["C0034665#ent", "<e1>", "is", "an", "effective", "and", "safe", "treatment", "for", "healing", "C0038358#ent", "<e2>", "with", "a", "tendency", "to", "produce", "a", "faster", "healing", "rate", "than", "cimetidine", "during", "the", "first", "4", "weeks", "of", "treatment", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [10, 11]}}
{"token": ["With", "a", "C0017740#ent", "<e1>", "one", "bottle", "and", "the", "C0036023#ent", "<e2>", "solution", "in", "another", ",", "a", "combination", "of", "which", "matches", "the", "above", "mixture", ",", "the", "rats", "also", "show", "large", "intakes", "."], "h": {"id": "C0017740", "name": "C0017740#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036023", "name": "C0036023#ent", "pos": [8, 9]}}
{"token": ["These", "data", "are", "the", "first", "to", "strongly", "suggest", "that", "C1337092#ent", "<e1>", ",", "via", "CCR2", "present", "on", "brain", "endothelial", "cells", "contributes", "to", "increased", "C0669365#ent", "<e2>", "."], "h": {"id": "C1337092", "name": "C1337092#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [22, 23]}}
{"token": ["Although", "the", "C0003290#ent", "<e1>", "imipramine", "and", "C0013085#ent", "<e2>", "exert", "similar", "direct", "electrophysiological", "effects", "cardiac", "cells", "toxic", "cardiac", "arrhythmias", "conduction", "disturbances", "are", "much", "more", "commonly", "associated", "with", "imipramine", "than", "C0013085#ent", "<e2>", "in", "clinical", "use"], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013085", "name": "C0013085#ent", "pos": [6, 7]}}
{"token": ["Also", "calcium", "channel", "antagonists", "flunaricine", "and", "C0003290#ent", "<e1>", "amitryptiline", "and", "C0013085#ent", "<e2>", "are", "used", "."], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013085", "name": "C0013085#ent", "pos": [10, 11]}}
{"token": ["Response", "of", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "to", "phytohemagglutinin", "(", "C0030779#ent", "<e1>", ")", "diminished", "in", "patients", "with", "C0036467#ent", "<e2>", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0036467", "name": "C0036467#ent", "pos": [18, 19]}}
{"token": ["Thirteen", "children", "requiring", "urgent", "thoracotomy", "for", "relief", "of", "C0748355#ent", "<e1>", "from", "critical", "major", "airway", "narrowing", "caused", "by", "enlarged", "C0041316#ent", "<e2>", "admitted", "to", "two", "hospitals", "over", "a", "4-year", "period", "."], "h": {"id": "C0748355", "name": "C0748355#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041316", "name": "C0041316#ent", "pos": [18, 19]}}
{"token": ["RNA", "interference-induced", "knockdown", "of", "Zap70", "or", "C3853652#ent", "<e1>", "in", "Jurkat", "cells", "peripheral", "blood", "T", "lymphocytes", "resulted", "in", "the", "loss", "of", "C1420341#ent", "<e2>", "expression", "."], "h": {"id": "C3853652", "name": "C3853652#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420341", "name": "C1420341#ent", "pos": [20, 21]}}
{"token": ["The", "three", "formate", "dehydrogenases", "molybdo-selenoproteins", "while", "the", "three", "C0020284#ent", "<e1>", "are", "nickel", "C3540790#ent", "<e2>", ";", "all", "six", "C3540790#ent", "<e2>", "have", "an", "abundance", "of", "iron-sulfur", "clusters"], "h": {"id": "C0020284", "name": "C0020284#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}}
{"token": ["C0001403#ent", "<e1>", "a", "low", "incidence", "is", "most", "frequently", "the", "result", "of", "an", "C0004364#ent", "<e2>", "developed", "countries", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [12, 13]}}
{"token": ["To", "test", "the", "hypothesis", "that", "MAN1", "function", "might", "overlap", "with", "C1414386#ent", "<e1>", ",", "we", "tested", "different", "C1305923#ent", "<e2>", "MAN1", "for", "binding", "to", "selected", "partners", "of", "C1414386#ent", "<e1>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1414386", "name": "C1414386#ent", "pos": [10, 11]}}
{"token": ["Structural", "requirements", "inhibition", "with", "antifolates", "have", "been", "studied", "extensively", "and", "novel", "C0035064#ent", "<e1>", "that", "exploit", "key", "interactions", "in", "the", "active", "site", "C1420620#ent", "<e2>", ",", "DHFR", ",", "FPGS", ",", "and", "RFC", "have", "been", "proposed", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [21, 22]}}
{"token": ["Resiniferatoxin", "has", "been", "shown", "to", "increase", "bladder", "capacity", "and", "improve", "C0021167#ent", "<e1>", "in", "patients", "with", "C1417685#ent", "<e2>", "and", "non-neurogenic", "detrusor", "overactivity", "."], "h": {"id": "C0021167", "name": "C0021167#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417685", "name": "C1417685#ent", "pos": [15, 16]}}
{"token": ["The", "three", "C1417679#ent", "<e1>", "known", "to", "be", "involved", "in", "POAG", "(", "C1417573#ent", "<e2>", ",", "CYP1B1", "and", "OPTN", ")", "account", "for", "up", "to", "18", "%", "of", "the", "POAG", "cases", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417573", "name": "C1417573#ent", "pos": [11, 12]}}
{"token": ["In", "3T3-L1", "cells", "C0043167#ent", "<e1>", "toxin", "treatment", "did", "not", "alter", "levels", "of", "C1705766#ent", "<e2>", "alpha-subunits", ";", "in", "S49", "cells", "the", "level", "of", "C1705766#ent", "<e2>", "alpha-subunits", "declined", "moderately", "following", "by", "C0043167#ent", "<e1>", "toxin", "treatment", "."], "h": {"id": "C1705766", "name": "C1705766#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [3, 4]}}
{"token": ["AAG", "concentrations", "tended", "to", "rise", "in", "patients", "with", "acute", "myocardial", "infarction", "C0340293#ent", "<e1>", ")", ",", "leading", "to", "binding", "of", "the", "C1254351#ent", "<e2>", "in", "plasma", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [20, 21]}}
{"token": ["within", "4", "hr", "of", "the", "onset", "of", "chest", "pain", "and", "the", "third", "group", "patients", "who", "developed", "C0340293#ent", "<e1>", "while", "on", "propranolol", "therapy", "were", "maintained", "on", "this", "C1254351#ent", "<e2>", "after", "admission", "to", "the", "hospital", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [26, 27]}}
{"token": ["The", "production", "of", "estrogen", "from", "C3536949#ent", "<e1>", "via", "the", "estrogen", "biosynthesis", "pathway", "catalyzed", "by", "aromatase", "P450", "C3254086#ent", "<e2>", ")", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3254086", "name": "C3254086#ent", "pos": [16, 17]}}
{"token": ["The", "production", "of", "estrogen", "from", "C3536949#ent", "<e1>", "via", "the", "estrogen", "biosynthesis", "pathway", "catalyzed", "by", "aromatase", "P450", "C3254086#ent", "<e2>", ")", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3254086", "name": "C3254086#ent", "pos": [16, 17]}}
{"token": ["C4283742#ent", "<e1>", "genes", "encode", "UDP-glucose", ":", "C1421319#ent", "<e2>", "which", "catalyze", "the", "final", "step", "in", "the", "biosynthesis", "of", "the", "membrane", "lipid", "glucosylceramide"], "h": {"id": "C4283742", "name": "C4283742#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421319", "name": "C1421319#ent", "pos": [6, 7]}}
{"token": ["This", "effect", "is", "mediated", "by", "high-affinity", "TrkA", "receptor", "nerve", "growth", "factor", "NGF", ")", "induced", "the", "phosphorylation", "of", "C2348503#ent", "<e1>", "only", "in", "C1704884#ent", "<e2>", "expressing", "cells", "and", "not", "p75-expressing", "cells", "."], "h": {"id": "C2348503", "name": "C2348503#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1704884", "name": "C1704884#ent", "pos": [21, 22]}}
{"token": ["C1852540#ent", "<e1>", "a", "serious", "but", "treatable", "cause", "of", "C0270697#ent", "<e2>", "that", "may", "be", "misdiagnosed", "as", "recent", "onset", "migraine", "."], "h": {"id": "C1852540", "name": "C1852540#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [8, 9]}}
{"token": ["C0073561#ent", "<e1>", "dose-dependently", "inhibited", "the", "interferon-gamma", "(IFN-gamma)-stimulated", "phosphorylation", "of", "C1120843#ent", "<e2>", "MAP", ")", "kinase", "in", "a", "simple", "monotonic", "fashion", "with", "an", "IC(50", ")", "value", "of", "approx", "."], "h": {"id": "C0073561", "name": "C0073561#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [9, 10]}}
{"token": ["C0678133#ent", "<e1>", "also", "elicits", "cell", "signals", "a", "manner", "indistinguishable", "from", "bacterial", "lipopolysaccharide", "C2697656#ent", "<e2>", ")", "."], "h": {"id": "C0678133", "name": "C0678133#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [12, 13]}}
{"token": ["In", "colchicine-treated", "rats", "insulin-induced", "C0020615#ent", "<e1>", "resulted", "in", "a", "prominent", "decline", "in", "C1366488#ent", "<e2>", "and", "AVP", "concentrations", "in", "the", "ZEME", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1366488", "name": "C1366488#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "obese", "women", "have", "a", "normal", "cortisol", "response", "hypothalamic-pituitary", "stimulation", "C0020615#ent", "<e1>", "and", "direct", "adrenal", "stimulation", "synacthen", "but", "an", "impaired", "adrenal", "response", "pituitary", "stimulation", "C1366488#ent", "<e2>", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1366488", "name": "C1366488#ent", "pos": [26, 27]}}
{"token": ["These", "results", "support", "the", "view", "that", "C0078752#ent", "<e1>", "increases", "SV(N", ")", "above", "the", "C0669365#ent", "<e2>", "level", "in", "a", "concentration-dependent", "manner", "and", "that", "zeaxanthin-dependent", "SV(N", ")", "occurs", "in", "the", "pigment", "bed", "."], "h": {"id": "C0078752", "name": "C0078752#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [13, 14]}}
{"token": ["Focal", "segmental", "glomerulosclerosis", "C4049702#ent", "<e1>", ")", "is", "a", "C0268769#ent", "<e2>", "characteristic", "glomerular", "sclerosis"], "h": {"id": "C4049702", "name": "C4049702#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268769", "name": "C0268769#ent", "pos": [8, 9]}}
{"token": ["Disturbances", "of", "consciousness", ",", "dysphasia", ",", "C0233763#ent", "<e1>", "upper", "motor", "neuron", "deficit", "tremor", ",", "dizziness", ",", "numbness", ",", "C0231528#ent", "<e2>", "and", "headache", ",", "all", "of", "them", "neurological", "complications", "interferon", "treatment", "are", "discussed", "."], "h": {"id": "C0233763", "name": "C0233763#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [18, 19]}}
{"token": ["Death", ",", "another", "C0027051#ent", "<e1>", "or", "both", "were", "significantly", "reduced", "by", "C0025859#ent", "<e2>", "treatment", "in", "patients", "with", "exercise-induced", "ST", "depression", "greater", "than", "or", "equal", "to", "1", "mm", "at", "the", "6-week", "test", "."], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [11, 12]}}
{"token": ["Rat", "T", "cells", "like", "those", "of", "mouse", "and", "human", "origin", ",", "respond", "strongly", "to", "superantigens", "(", "C1419428#ent", "<e1>", ")", "derived", "from", "Staphylococcus", "aureus", "enterotoxins", "A", "B", "(", "SEA", ",", "C1423585#ent", "<e2>", ")", "."], "h": {"id": "C1419428", "name": "C1419428#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1423585", "name": "C1423585#ent", "pos": [29, 30]}}
{"token": ["The", "disease", "is", "characterized", "by", "C0002066#ent", "<e1>", "ochronosis", "and", "C0268493#ent", "<e2>"], "h": {"id": "C0002066", "name": "C0002066#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0268493", "name": "C0268493#ent", "pos": [9, 10]}}
{"token": ["The", "most", "common", "clinical", "features", "are", "C0002066#ent", "<e1>", "pigmentation", "of", "cartilages", "and", "other", "connective", "tissues", "C0268493#ent", "<e2>", "cardiovascular", "ochronosis"], "h": {"id": "C0002066", "name": "C0002066#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0268493", "name": "C0268493#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "intracerebroventricular", "administration", "of", "beta-endorphin", ",", "C0057492#ent", "<e1>", ",", "D-ala2-methionine-enkephalinamide", "(", "DALA", ")", "and", "C0030873#ent", "<e2>", ",", "on", "behaviour", ",", "electrocortical", "activity", "ECoG", "spectrum", "power", "in", "young", "chicks", "were", "studied", "."], "h": {"id": "C0057492", "name": "C0057492#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030873", "name": "C0030873#ent", "pos": [16, 17]}}
{"token": ["Although", "a", "few", "uncontrolled", "studies", "describe", "the", "association", "of", "C0020538#ent", "<e1>", "AH", ")", "with", "C0019104#ent", "<e2>", ",", "their", "relationship", "remains", "to", "be", "elucidated", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "point", "to", "enhanced", "ROS-mediated", "inactivation", "and", "sequestration", "of", "NO", ",", "which", "may", "contribute", "to", "the", "reduction", "of", "bioactive", "NO", "and", "C0020538#ent", "<e1>", "in", "the", "C0019104#ent", "<e2>", "diet-fed", "animals", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [26, 27]}}
{"token": ["C0040864#ent", "<e1>", "significantly", "increases", "the", "activities", "of", "C0251211#ent", "<e2>", "kidney", "glucose-6-phosphatase", "and", "kidney", "phosphoenolpyruvate", "carboxykinase", ";", "ammonium", "chloride", "stimulates", "a", "200", "%", "increase", "in", "kidney", "phosphoenolpyruvate", "carboxykinase", "but", "has", "no", "effect", "the", "other", "enzymes", "."], "h": {"id": "C0040864", "name": "C0040864#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0251211", "name": "C0251211#ent", "pos": [7, 8]}}
{"token": ["The", "effects", "of", "C0040864#ent", "<e1>", "on", "renal", "and", "C0251211#ent", "<e2>", "activity", "in", "the", "developing", "rat", "were", "investigated", "."], "h": {"id": "C0040864", "name": "C0040864#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0251211", "name": "C0251211#ent", "pos": [8, 9]}}
{"token": ["in", "mice", "was", "associated", "with", "increased", "heart", "rate", "strong", "muscular", "hind", "limb", "paralysis", ",", "C0235055#ent", "<e1>", "dyspnea", ",", "loss", "of", "spontaneous", "activity", "by", "C0264490#ent", "<e2>"], "h": {"id": "C0235055", "name": "C0235055#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [23, 24]}}
{"token": ["The", "significance", "of", "the", "relatively", "low", "serum", "C3272447#ent", "<e1>", "and", "TG", "and", "high", "HDL-C", "in", "relation", "to", "low", "C0007222#ent", "<e2>", "Chinese", "populations", "the", "object", "of", "further", "investigation", "in", "follow-up", "studies", "."], "h": {"id": "C3272447", "name": "C3272447#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [18, 19]}}
{"token": ["Opsin", ",", "the", "alpha-subunit", "of", "transducin", ",", "S-antigen", ",", "interphotoreceptor", "retinoid-binding", "protein", "IRBP", ")", "and", "cathepsin", "D", "assessed", "in", "autopsy", "C0235267#ent", "<e1>", "from", "patients", "with", "C0220701#ent", "<e2>", "RP", ")", "and", "normal", "autopsy", "C0235267#ent", "<e1>", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [25, 26]}}
{"token": ["The", "C0235267#ent", "<e1>", "of", "two", "brothers", "with", "C0220701#ent", "<e2>", "removed", "after", "death", "and", "examined", "by", "a", "variety", "of", "techniques", ",", "including", "conventional", "histology", ",", "fluorescence", "microscopy", "both", "scanning", "and", "transmission", "electron", "microscopy"], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [7, 8]}}
{"token": ["Northern", "analysis", "that", "expression", "of", "the", "AdXET1", "-", "6", "C1335597#ent", "<e1>", "induced", "in", "ripening", "kiwifruit", "endogenous", "C0015075#ent", "<e2>", "production", "could", "first", "be", "detected", ",", "and", "peaked", "in", "climacteric", "samples", "fruit", "were", "soft", "."], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015075", "name": "C0015075#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "indicate", "that", "the", "tomato", "CTR1", "C1335597#ent", "<e1>", "differentially", "regulated", "at", "the", "mRNA", "level", "by", "C0015075#ent", "<e2>", "and", "during", "stages", "of", "development", "marked", "by", "increased", "ethylene", "biosynthesis", "including", "fruit", "ripening", "."], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015075", "name": "C0015075#ent", "pos": [16, 17]}}
{"token": ["We", "describe", "the", "complete", "open", "reading", "frame", "sequence", "HOXC10", "and", "C1415677#ent", "<e1>", "along", "with", "the", "structure", "of", "the", "C3273502#ent", "<e2>"], "h": {"id": "C1415677", "name": "C1415677#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273502", "name": "C3273502#ent", "pos": [18, 19]}}
{"token": ["Engagement", "of", "C4283784#ent", "<e1>", "activated", "the", "GTPase", "C0034678#ent", "<e2>", "through", "a", "mechanism", "that", "did", "not", "require", "tyrosine", "phosphorylation", "C4283784#ent", "<e1>", "or", "association", "of", "the", "Shc", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [2, 3]}}
{"token": ["By", "immunohistochemical", "examination", ",", "tumor", "cells", "positive", "for", "epithelial", "markers", ",", "such", "as", "C1416713#ent", "<e1>", "and", "epithelial", "membrane", "antigen", "and", "neuron", "specific", "C0031691#ent", "<e2>", ",", "but", "negative", "for", "any", "other", "neuro-endocrine", "markers"], "h": {"id": "C1416713", "name": "C1416713#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031691", "name": "C0031691#ent", "pos": [22, 23]}}
{"token": ["We", "used", "subretinal", "injection", "of", "a", "recombinant", "replication-deficient", "adenovirus", "encoding", "rat", "C1706554#ent", "<e1>", "to", "deliver", "the", "C0079429#ent", "<e2>", "to", "the", "eyes", "of", "young", "RCS", "rats", "."], "h": {"id": "C1706554", "name": "C1706554#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["The", "comparison", "of", "their", "expression", "patterns", "in", "human", "and", "mice", "tissues", "suggested", "that", "the", "C1706554#ent", "<e1>", "the", "best", "C0079429#ent", "<e2>", "to", "screen", "for", "mutations", "."], "h": {"id": "C1706554", "name": "C1706554#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}}
{"token": ["Pulmonary", "manifestations", "adult-onset", "Still's", "disease", "AOSD", ")", "include", "C3714636#ent", "<e1>", "pleural", "effusions", "rarely", "acute", "respiratory", "distress", "syndrome", "and", "C0085581#ent", "<e2>"], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085581", "name": "C0085581#ent", "pos": [18, 19]}}
{"token": ["In", "case", "of", "C3714636#ent", "<e1>", ",", "PFT", "showed", "a", "C0085581#ent", "<e2>", "a", "reduced", "TLCO", "."], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085581", "name": "C0085581#ent", "pos": [9, 10]}}
{"token": ["Cerebellar", "granule", "neurons", "express", "significant", "levels", "of", "C1705378#ent", "<e1>", "mRNA", "and", "protein", ",", "but", "expression", "of", "RIAP1", ",", "C1332413#ent", "<e2>", ",", "and", "XIAP", "was", "not", "detected", "."], "h": {"id": "C1705378", "name": "C1705378#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332413", "name": "C1332413#ent", "pos": [18, 19]}}
{"token": ["C0007194#ent", "<e1>", "HCM", "or", "CMH", ")", "is", "a", "C3241958#ent", "<e2>", "by", "mutations", "that", "affect", "the", "contractile", "machinery", "heart", "muscle", "cells"], "h": {"id": "C0007194", "name": "C0007194#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3241958", "name": "C3241958#ent", "pos": [8, 9]}}
{"token": ["The", "relative", "efficacy", "and", "safety", "of", "flurbiprofen", "(", "Ansaid", ",", "Upjohn", ")", "and", "C0021246#ent", "<e1>", "were", "compared", "in", "29", "patients", "with", "C0003868#ent", "<e2>", "less", "than", "48", "hours", "'", "duration", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0003868", "name": "C0003868#ent", "pos": [21, 22]}}
{"token": ["Activation", "of", "C1705325#ent", "<e1>", "glucose-dependent", "insulinotropic", "polypeptide", "glucose", "was", "associated", "with", "C1334133#ent", "<e2>", "isoforms", "insulin", "receptor", "substrate-2", "growth", "factor", "bound-2", "binder-1", "and", "PI3", "K", "isoforms", "p85alpha", ",", "p110alpha", ",", "p110beta", ",", "and", "p110gamma", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [11, 12]}}
{"token": ["AGE-1", ",", "a", "homolog", "of", "the", "p110", "catalytic", "subunit", "phosphoinositide", "3-kinases", "C1705325#ent", "<e1>", "comprises", "the", "major", "known", "effector", "pathway", "downstream", "of", "the", "C1334133#ent", "<e2>", "DAF-2", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [22, 23]}}
{"token": ["C0085624#ent", "<e1>", "application", ",", "a", "common", "problem", "with", "the", "C0005088#ent", "<e2>", "alcohol", "gels", "was", "not", "reported", "by", "patients", "using", "the", "benzoyl", "peroxide", "acetone", "gel"], "h": {"id": "C0085624", "name": "C0085624#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005088", "name": "C0005088#ent", "pos": [9, 10]}}
{"token": ["C0013295#ent", "<e1>", "relapse", "rates", "after", "therapy", "with", "C0038633#ent", "<e2>", "or", "bismuth", "are", "lower", "than", "those", "after", "H2-receptor", "antagonist", "therapy", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0038633", "name": "C0038633#ent", "pos": [7, 8]}}
{"token": ["Since", "several", "neuroactive", "C0038317#ent", "<e1>", "are", "substrates", "or", "products", "of", "the", "3", "C3489584#ent", "<e2>", "enzymatic", "activity", ",", "our", "findings", "offer", "new", "possibilities", "to", "study", "the", "regulatory", "mechanisms", "their", "biosynthesis", "in", "the", "brain", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3489584", "name": "C3489584#ent", "pos": [12, 13]}}
{"token": ["We", "have", "thus", "investigated", "the", "subcellular", "localization", "two", "enzymes", "involved", "in", "the", "production", "of", "C0038317#ent", "<e1>", "namely", "3beta-hydroxysteroid", "dehydrogenase", "(", "C3489584#ent", "<e2>", ")", "and", "type", "5", "17beta-hydroxysteroid", "dehydrogenase", "17beta-HSD", ")", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3489584", "name": "C3489584#ent", "pos": [20, 21]}}
{"token": ["The", "removal", "of", "adherent", "cells", "reduced", "both", "the", "control", "C1427267#ent", "<e1>", "activity", "and", "the", "response", "to", "the", "C0026249#ent", "<e2>", "."], "h": {"id": "C1427267", "name": "C1427267#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [17, 18]}}
{"token": ["We", "present", "a", "10", "year", "old", "boy", "with", "C0410422#ent", "<e1>", "improved", "after", "treatment", "with", "C0027396#ent", "<e2>", "."], "h": {"id": "C0410422", "name": "C0410422#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [14, 15]}}
{"token": ["C0796092#ent", "<e1>", "a", "rare", "condition", "characterized", "by", "C0155285#ent", "<e2>", "skin", "tags"], "h": {"id": "C0796092", "name": "C0796092#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0155285", "name": "C0155285#ent", "pos": [7, 8]}}
{"token": ["We", "have", "previously", "shown", "that", "myosin", "II", "regulatory", "light", "chain", "C1416491#ent", "<e1>", ")", "binds", "directly", "to", "C0599220#ent", "<e2>", "of", "the", "NMDA-type", "glutamate", "receptor", "NR", ")", ",", "suggesting", "that", "NMDA", "receptors", "closely", "associated", "with", "myosin", "II", "motor", "complex"], "h": {"id": "C1416491", "name": "C1416491#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}}
{"token": ["The", "C0018523#ent", "<e1>", "HSS", ")", "is", "a", "rare", "condition", "characterized", "by", "C0015371#ent", "<e2>", "and", "pyramidal", "signs", ",", "dystonia", ",", "dysarthria", ",", "retinal", "degeneration", "dementia", "and", "a", "progressive", "course", "."], "h": {"id": "C0018523", "name": "C0018523#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [11, 12]}}
{"token": ["The", "C0018523#ent", "<e1>", "typically", "thought", "of", "as", "a", "paediatric", "condition", "with", "C0015371#ent", "<e2>", "features", "and", "dementia", "."], "h": {"id": "C0018523", "name": "C0018523#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [11, 12]}}
{"token": ["x13", "days", ")", "or", "both", "C0991617#ent", "<e1>", "immediately", "following", "heart", "transplantation", "C2700301#ent", "<e2>", ")", "and", "were", "killed", "10", "or", "21", "days", "later", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2700301", "name": "C2700301#ent", "pos": [11, 12]}}
{"token": ["Using", "this", "method", ",", "four", "infants", "have", "been", "found", "to", "suffer", "from", "C0016952#ent", "<e1>", "due", "to", "C0020625#ent", "<e2>"], "h": {"id": "C0016952", "name": "C0016952#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "suggest", "that", "plants", "and", "other", "natural", "products", "be", "a", "source", "of", "C0991617#ent", "<e1>", "that", "can", "potentially", "alter", "glycosaminoglycan", "and", "C1418888#ent", "<e2>", "formation", "in", "animal", "cells"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [21, 22]}}
{"token": ["Certain", "C0991617#ent", "<e1>", "of", "the", "C1418888#ent", "<e2>", "nature", "possessing", "organ-specific", "rather", "than", "the", "species-specific", "antimitotic", "chalone", "activity", "have", "been", "obtained", "from", "the", "normal", "bovine", "spleen", "thymus", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [5, 6]}}
{"token": ["Expression", "studies", "C1422763#ent", "<e1>", "that", "testosterone", "was", "aromatized", "to", "C2936882#ent", "<e2>", "in", "the", "MCF-7", "cells"], "h": {"id": "C1422763", "name": "C1422763#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "agonists", "were", "antagonized", "by", "C2744579#ent", "<e1>", ",", "with", "a", "C1839576#ent", "<e2>", "value", "in", "each", "case", "consistent", "with", "inhibition", "by", "C2744579#ent", "<e1>", "of", "ADP-induced", "aggregation", "."], "h": {"id": "C1839576", "name": "C1839576#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [7, 8]}}
{"token": ["In", "this", "report", ",", "we", "further", "characterized", "the", "cis-elements", "of", "the", "murine", "C1420172#ent", "<e1>", "promoter", ",", "which", "confers", "glucose", "responsiveness", "a", "C0206414#ent", "<e2>", "chloramphenicol", "acetyl", "transferase", "CAT", ")", "gene", "."], "h": {"id": "C1420172", "name": "C1420172#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0206414", "name": "C0206414#ent", "pos": [21, 22]}}
{"token": ["The", "interaction", "between", "Dv12", "and", "C1705397#ent", "<e1>", "detected", "by", "yeast", "two-hybrid", "system", "that", "C1705397#ent", "<e1>", "might", "play", "a", "role", "in", "some", "biological", "processes", "C1414199#ent", "<e1>", "."], "h": {"id": "C1705397", "name": "C1705397#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414199", "name": "C1414199#ent", "pos": [23, 24]}}
{"token": ["All", "three", "isozymes", "were", "present", "in", "type", "I", "fibers", "CAII", "and", "C1413044#ent", "<e1>", "were", "exclusive", "to", "these", "fibers", ",", "and", "C0064494#ent", "<e2>", "were", "also", "present", "in", "some", "small", "type", "2A", "fibers"], "h": {"id": "C1413044", "name": "C1413044#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0064494", "name": "C0064494#ent", "pos": [20, 21]}}
{"token": ["To", "test", "a", "new", "anti-apoptosis", "strategy", "for", "C0242912#ent", "<e1>", ",", "we", "engineered", "nontoxic", "components", "of", "C1427242#ent", "<e2>", "a", "Bcl-XL", "delivery", "system", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1427242", "name": "C1427242#ent", "pos": [15, 16]}}
{"token": ["The", "activity", "of", "glutamate", "dehydrogenase", "NAD-specific", ")", ",", "however", ",", "was", "only", "1/3", "of", "that", "in", "the", "C0003290#ent", "<e1>", ",", "and", "no", "C1413745#ent", "<e2>", "detected", "in", "differentiating", "culture", "."], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413745", "name": "C1413745#ent", "pos": [22, 23]}}
{"token": ["Lesions", "to", "ventral", "occipital", "cortex", "produce", "severe", "deficits", "in", "color", "vision", "a", "C0039082#ent", "<e1>", "known", "as", "C0152200#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0152200", "name": "C0152200#ent", "pos": [16, 17]}}
{"token": ["Some", "of", "such", "complications", "(", "i.e.", "transverse", "myelitis", "C0032586#ent", "<e1>", ",", "leucoencephalopathy", ")", "must", "rise", "the", "suspicion", "of", "an", "C0019693#ent", "<e2>"], "h": {"id": "C0032586", "name": "C0032586#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [19, 20]}}
{"token": ["However", ",", "C1704264#ent", "<e1>", "attenuated", "the", "enhanced", "phosphorylation", "level", "of", "C1456378#ent", "<e2>", "p38", "MAPK", "without", "affecting", "extracellular", "signal-regulated", "protein", "kinase", "ERK", ")", "inactivation", "induced", "by", "evodiamine", "."], "h": {"id": "C1704264", "name": "C1704264#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [10, 11]}}
{"token": ["Three", "groups", "of", "patients", "could", "be", "differentiated", ":", "Patients", "without", "C0018799#ent", "<e1>", "Patients", "with", "C0149721#ent", "<e2>", "ASD", ";", "Patients", "with", "left", "ventricular", "enlargement", "aortic", "and", "mitral", "valve", "disease"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0149721", "name": "C0149721#ent", "pos": [14, 15]}}
{"token": ["The", "extent", "of", "C0018799#ent", "<e1>", "elevation", "in", "cardiac", "enzymes", "C0149721#ent", "<e2>", "previous", "coronary", "artery", "disease", "elapsed", "time", "from", "symptom", "onset", "to", "infarction", "at", "entry", "to", "study", "showed", "no", "significant", "between", "the", "two", "groups", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149721", "name": "C0149721#ent", "pos": [9, 10]}}
{"token": ["Compared", "with", "rats", "given", "C0016860#ent", "<e1>", "only", ",", "C0031448#ent", "<e2>", "attenuated", "dose-dependently", "the", "diuretic", "and", "natriuretic", "peak", "response", "to", "C0016860#ent", "<e1>", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [4, 5]}}
{"token": ["C0017168#ent", "<e1>", "the", "most", "common", "cause", "of", "C0013395#ent", "<e2>", "in", "the", "community", ",", "and", "is", "usually", "chronic", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [7, 8]}}
{"token": ["C0017168#ent", "<e1>", "GERD", ")", "and", "C0013395#ent", "<e2>", "affect", "25", "-", "40", "%", "of", "the", "general", "population"], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [5, 6]}}
{"token": ["Three", "PKC", "C0022173#ent", "<e1>", ",", "alpha", ",", "epsilon", ",", "and", "C3889400#ent", "<e2>", ",", "were", "identified", "by", "Western", "blotting", "IIC9", "cells", "and", "were", "mainly", "localized", "in", "the", "cytosol", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889400", "name": "C3889400#ent", "pos": [10, 11]}}
{"token": ["Vascular", "smooth", "muscle", "cells", "found", "to", "express", "at", "least", "four", "different", "PKC", "C0022173#ent", "<e1>", ":", "alpha", ",", "delta", ",", "C3889400#ent", "<e2>", ",", "and", "a", "faint", "band", "for", "epsilon", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3889400", "name": "C3889400#ent", "pos": [19, 20]}}
{"token": ["However", ",", "there", "are", "no", "reports", "about", "using", "C1705997#ent", "<e1>", "for", "idiopathic", "C1858160#ent", "<e2>", ",", "which", "is", "not", "associated", "with", "heart", "failure", "other", "serious", "medical", "problems", "."], "h": {"id": "C1705997", "name": "C1705997#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1858160", "name": "C1858160#ent", "pos": [12, 13]}}
{"token": ["The", "last", "seven", "C-terminal", "aa", "unrelated", "to", "the", "previously", "characterized", "C1969618#ent", "<e1>", "-", "67", "peptides", "due", "to", "a", "change", "in", "the", "C0079941#ent", "<e2>"], "h": {"id": "C1969618", "name": "C1969618#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [21, 22]}}
{"token": ["Exposure", "to", "70", "%", "oxygen", "between", "the", "ages", "of", "4", "and", "11", "days", "caused", "afar", "greater", "accumulation", "of", "carbonyl", "in", "mev-1", "than", "in", "C1883559#ent", "<e1>", "but", "not", "in", "C3539760#ent", "<e2>", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3539760", "name": "C3539760#ent", "pos": [28, 29]}}
{"token": ["However", ",", "the", "level", "of", "gene", "expression", "SOD", "and", "catalase", "was", "not", "elevated", "by", "short-term", "exposure", "to", "%", "oxygen", "in", "C1883559#ent", "<e1>", "mev-1", ",", "daf-16", "and", "even", "C3539760#ent", "<e2>", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3539760", "name": "C3539760#ent", "pos": [27, 28]}}
{"token": ["Cerebellar", "superoxide", "dismutase", "SOD", ")", "and", "C0132555#ent", "<e1>", "NOS", ")", "activities", "were", "measured", "and", "mRNA", "levels", "of", "C1743497#ent", "<e2>", ",", "CuZnSOD", ",", "and", "nNOS", "in", "the", "cerebellar", "granule", "cell", "layer", "quantitated", "by", "in", "situ", "hybridization"], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [17, 18]}}
{"token": ["The", "secretion", "stimulated", "by", "C0075807#ent", "<e1>", "and", "nobiletin", "was", "synergistic", "with", "C0006945#ent", "<e2>", "but", "not", "with", "vasoactive", "intestinal", "peptide", "was", "inhibited", "by", "barium", "chloride", "bumetanide", ",", "H-89", ",", "and", "Cl-", "depletion", "."], "h": {"id": "C0075807", "name": "C0075807#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [11, 12]}}
{"token": ["Low", "dose", "aspirin", "is", "commonly", "prescribed", "in", "C0019099#ent", "<e1>", "and", "may", "attenuate", "the", "C3537240#ent", "<e2>", "effects", "of", "ACE", "inhibitors"], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [13, 14]}}
{"token": ["Over-expression", "of", "LARGE", "in", "cells", "from", "patients", "with", "mutations", "in", "POMT1", "or", "C1100372#ent", "<e1>", "results", "in", "hyperglycosylation", "of", "C1413902#ent", "<e2>", "and", "restoration", "of", "laminin", "binding"], "h": {"id": "C1100372", "name": "C1100372#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413902", "name": "C1413902#ent", "pos": [18, 19]}}
{"token": ["Using", "either", "laminin", "attachment", "or", "tumor", "necrosis", "factor", "alpha", "a", "physiological", "stimulus", "of", "NF-kappaB", "activation", "we", "demonstrate", "that", "IkappaB", "kinase", "alpha", "C1704987#ent", "<e1>", ")", "is", "recruited", "to", "C0008546#ent", "<e2>", "in", "distinct", "phases", "."], "h": {"id": "C1704987", "name": "C1704987#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [27, 28]}}
{"token": ["Hera", "has", "a", "specific", "ATPase", "activity", "480", "units/microg", "and", "therefore", ",", "displays", "the", "highest", "C0001473#ent", "<e1>", "specific", "activity", "reported", "for", "a", "protein", "of", "the", "C0084378#ent", "<e2>"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0084378", "name": "C0084378#ent", "pos": [24, 25]}}
{"token": ["Genetic", "polymorphisms", "C0919426#ent", "<e1>", "in", "5'-flanking", "and", "C0079941#ent", "<e2>", "been", "found", "previously", "in", "Caucasian", "and", "Chinese", "populations"], "h": {"id": "C0919426", "name": "C0919426#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}}
{"token": ["We", "have", "isolated", "a", "cDNA", "(", "named", "P450", "A", "which", "is", "a", "variant", "of", "C0919426#ent", "<e1>", "presenting", "some", "differences", "in", "the", "3", "'", "C0079941#ent", "<e2>"], "h": {"id": "C0919426", "name": "C0919426#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [23, 24]}}
{"token": ["Treatment", "with", "metformin", "significantly", "reduced", "the", "incidence", "of", "C0011849#ent", "<e1>", "in", "subjects", "with", "IGT", "and", "high-normal", "fasting", "plasma", "glucose", "the", "C1447020#ent", "<e2>", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1447020", "name": "C1447020#ent", "pos": [20, 21]}}
{"token": ["Her", "seizure", "initially", "appeared", "as", "afebrile", "general", "tonic", "C0234535#ent", "<e1>", "progressed", "to", "typical", "C0037769#ent", "<e2>", "of", "clusters", "of", "myoclonic", "spasms", "the", "extremities", ",", "mainly", "on", "the", "left", "side", "accompanied", "by", "head", "and", "eye", "deviation", "the", "right", "side"], "h": {"id": "C0234535", "name": "C0234535#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037769", "name": "C0037769#ent", "pos": [13, 14]}}
{"token": ["To", "elucidate", "the", "regulation", "of", "obese", "(", "C1413269#ent", "<e1>", ")", "gene", "expression", "obesity", "and", "C0011849#ent", "<e2>", ",", "we", "examined", "ob", "gene", "in", "KK", "mice", "and", "congenic", "lethal", "yellow", "obese", "KKAy", "mice", "."], "h": {"id": "C1413269", "name": "C1413269#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}}
{"token": ["C3889248#ent", "<e1>", "also", "inhibited", "nitrite", "production", "in", "C0175697#ent", "<e2>", "stimulated", "RAW", "264.7", "."], "h": {"id": "C3889248", "name": "C3889248#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [7, 8]}}
{"token": ["GSH", "causes", "a", "marked", "increase", "in", "extractable", "PAL", "activity", ",", "whereas", "the", "oxidized", "form", "of", "glutathione", ",", "constituent", "C3539947#ent", "<e1>", "or", "other", "reducing", "C0035064#ent", "<e2>", "are", "inactive", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "site-directed", "mutagenesis", "studies", "have", "identified", "the", "C3539947#ent", "<e1>", "for", "the", "binding", "of", "some", "of", "these", "C0035064#ent", "<e2>", "to", "P-glycoprotein", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}}
{"token": ["In", "summary", ",", "the", "essential", "C3539947#ent", "<e1>", "stimulate", "bone", "formation", "could", "represents", "useful", "C0035064#ent", "<e2>", "for", "the", "prevention", "and", "therapy", "of", "osteoporosis", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}}
{"token": ["To", "treat", "spasticity", ",", "neurologists", "usually", "prescribe", "drugs", "as", "baclofen", ",", "C0146011#ent", "<e1>", "or", "benzodiazepines", "or", "even", "use", "definitive", "treatment", "as", "C0031428#ent", "<e2>", "or", "surgery", "."], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [21, 22]}}
{"token": ["Hyponatraemia", "(", "serum", "sodium", "than", "130", "mmol/l", ")", "was", "not", "significantly", "commoner", "in", "the", "41", "patients", "prescribed", "C0066684#ent", "<e1>", "than", "in", "patients", "prescribed", "other", "C0012798#ent", "<e2>", "."], "h": {"id": "C0066684", "name": "C0066684#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [24, 25]}}
{"token": ["Reversed-phase", "chromatography", "tiotropium", "and", "the", "internal", "standard", "C0008932#ent", "<e1>", "was", "carried", "out", "using", "acetonitrile/10", "mM", "C0718495#ent", "<e2>", "1", "%", "formic", "acid", "40:60", "as", "mobile", "phase", "a", "run", "time", "of", "3.0", "min", "."], "h": {"id": "C0008932", "name": "C0008932#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0718495", "name": "C0718495#ent", "pos": [15, 16]}}
{"token": ["Beta-blockade", "by", "C0000946#ent", "<e1>", "was", "highly", "effective", "in", "treating", "mild-moderate", "C0020538#ent", "<e2>", "the", "elderly", "."], "h": {"id": "C0000946", "name": "C0000946#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [10, 11]}}
{"token": ["The", "results", "obtained", "reveal", "that", "the", "monotherapy", "with", "C0000946#ent", "<e1>", ",", "in", "light", "and", "moderate", "C0020538#ent", "<e2>", "leads", "to", "definite", ",", "lasting", "and", "progressive", "antihypertensive", "effect", "over", "75", "%", "of", "the", "patients", "."], "h": {"id": "C0000946", "name": "C0000946#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [15, 16]}}
{"token": ["It", "also", "appeared", "that", "the", "enzymes", "responsible", "are", "more", "likely", "to", "be", "C0172537#ent", "<e1>", "and", "elastase-like", "enzymes", "than", "specific", "C0162745#ent", "<e2>", "."], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [12, 13]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [19, 20]}}
{"token": ["The", "techniques", "could", "be", "used", "to", "measure", "the", "C0172537#ent", "<e1>", ",", "caseinase", ",", "and", "C0162745#ent", "<e2>", "activities", "of", "culture", "media", "conditioned", "by", "synovial", "tissue"], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [14, 15]}}
{"token": ["Addition", "of", "plasminogen", "to", "HT1080", "cells", "increased", "the", "C0172537#ent", "<e1>", ",", "and", "Pyr-Leu-Arg-CHO", "inhibited", "this", "activation", "of", "the", "C0162745#ent", "<e2>", "with", "an", "IC50", "of", "3", "micrograms/ml", "."], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [18, 19]}}
{"token": ["Paramecium", "dyneins", "tested", "as", "substrates", "for", "phosphorylation", "by", "cAMP-dependent", "protein", "kinase", "C1336838#ent", "<e1>", "and", "two", "C0248868#ent", "<e2>", "were", "partially", "purified", "from", "Paramecium", "extracts"], "h": {"id": "C1336838", "name": "C1336838#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0248868", "name": "C0248868#ent", "pos": [15, 16]}}
{"token": ["This", "may", "represent", "a", "misleading", "drawback", "if", "diagnosis", "of", "type", "1", "primary", "hyperoxaluria", "C1412402#ent", "<e1>", ")", "uniquely", "relies", "on", "C0069197#ent", "<e2>"], "h": {"id": "C1412402", "name": "C1412402#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0069197", "name": "C0069197#ent", "pos": [19, 20]}}
{"token": ["The", "C0208298#ent", "<e1>", "and", "B", "(", "APIA", "and", "C0009002#ent", "<e2>", ")", "are", "double-headed", "and", "multifunctional", "."], "h": {"id": "C0208298", "name": "C0208298#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [8, 9]}}
{"token": ["A", "poplar", "hybrid", ",", "Populus", "tremula", "Populus", "alba", "was", "transformed", "with", "the", "bacterial", "genes", "either", "C0017824#ent", "<e1>", "GR", ")", "(", "gor", ")", "or", "C0017834#ent", "<e2>", "GS", ")", "(", "gshII", ")", "."], "h": {"id": "C0017824", "name": "C0017824#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017834", "name": "C0017834#ent", "pos": [23, 24]}}
{"token": ["C0017824#ent", "<e1>", "nuclear", "extracts", "relatively", "unchanged", "during", "cataract", "progress", "while", "C0017834#ent", "<e2>", "significantly", "low", "in", "the", "advanced", "stages", "cataracts", "."], "h": {"id": "C0017824", "name": "C0017824#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017834", "name": "C0017834#ent", "pos": [10, 11]}}
{"token": ["Both", "patients", "had", "features", "of", "C0264220#ent", "<e1>", "evidence", "of", "pancreatic", "and", "other", "C0037285#ent", "<e2>"], "h": {"id": "C0264220", "name": "C0264220#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [12, 13]}}
{"token": ["To", "compare", "the", "safety", "and", "efficacy", "of", "fluticasone", "propionate", "aqueous", "nasal", "spray", "FPANS", ")", "and", "C0022642#ent", "<e1>", "children", "aged", "2", "-", "4", "years", "with", "C0035457#ent", "<e2>"], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [15, 16]}, "relation": "may_prevent", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [24, 25]}}
{"token": ["Fas", "ligand", "with", "a", "molecular", "weight", "45", "C1839259#ent", "<e1>", "appeared", "in", "the", "C0771711#ent", "<e2>", "of", "NOD", "mice", "during", "the", "onset", "of", "insulitis", "as", "demonstrated", "by", "western", "blot", "analysis"], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [12, 13]}}
{"token": ["Three", "of", "10", "acute", "fatal", "C1839259#ent", "<e1>", "cases", "had", "diffuse", "macrophage", "infiltration", "of", "the", "C0771711#ent", "<e2>", ";", "T", "cells", "not", "prominent", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [14, 15]}}
{"token": ["The", "human", "C1413181#ent", "<e1>", "Cak1", ")", "is", "itself", "a", "C4283918#ent", "<e2>", "associates", "with", "cyclin", "H.", "present", "study", "utilized", "specific", "anti-Cak1", "antibodies", "and", "immunoaffinity", "chromatography", "identify", "additional", "Cak1-associated", "proteins", "and", "potential", "target", "substrates", "."], "h": {"id": "C1413181", "name": "C1413181#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283918", "name": "C4283918#ent", "pos": [9, 10]}}
{"token": ["C0022265#ent", "<e1>", "RA", ")", "induces", "pattern", "duplication", "the", "proximodistal", "(", "C1335499#ent", "<e2>", ")", "axis", "of", "axolotl", "limb", "regenerates", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335499", "name": "C1335499#ent", "pos": [10, 11]}}
{"token": ["Ginkgetin", ",", "a", "biflavonoid", "from", "Ginkgo", "biloba", "leaves", "Ginkgoaceae", ")", ",", "was", "previously", "demonstrated", "to", "inhibit", "C0031667#ent", "<e1>", "to", "suppress", "proinflammatory", "gene", "such", "as", "cyclooxygenase-2", "(", "C1705323#ent", "<e2>", ")", "and", "inducible", "nitric", "oxide", "synthase"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [26, 27]}}
{"token": ["Thus", ",", "our", "results", "revealed", "a", "particular", "cross-talk", "between", "the", "two", "C0031667#ent", "<e1>", "enzymes", "and", "C1705323#ent", "<e2>", "for", "delayed", "PGE2", "biosynthesis", "by", "a", "type", "IIA", "sPLA2-deficient", "cell", "line", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [15, 16]}}
{"token": ["These", "compounds", "do", "not", "inhibit", "other", "C0020289#ent", "<e1>", "such", "as", "hepatic", "lipase", "C0023816#ent", "<e2>", "pancreatic", "lipase", "and", "butyrylcholine", "esterase"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [12, 13]}}
{"token": ["The", "C1705240#ent", "<e1>", "value", "for", "C0525773#ent", "<e2>", "however", ",", "was", "significantly", "higher", "in", "the", "aged", "group", "compared", "with", "the", "young", "and", "mature", "groups", ",", "indicating", "a", "decreased", "affinity", "of", "spinal", "mu-opioid", "receptors", "C0525773#ent", "<e2>", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0525773", "name": "C0525773#ent", "pos": [5, 6]}}
{"token": ["Liver", "function", "tests", "mild", "cytolysis", "C0008370#ent", "<e1>", "and", "massive", "C0022350#ent", "<e2>", "."], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0022350", "name": "C0022350#ent", "pos": [9, 10]}}
{"token": ["These", "results", "may", "suggest", "that", "mild", "hepatic", "dysfunction", "C0008370#ent", "<e1>", "is", "associated", "with", "indirect", "C0022350#ent", "<e2>", "in", "some", "infants", "with", "BMJ", "."], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0022350", "name": "C0022350#ent", "pos": [14, 15]}}
{"token": ["White", "Carneau", "pigeons", ",", "prone", "to", "atherosclerosis", ",", "were", "selectively", "bred", "for", "either", "high", "(", "C1415507#ent", "<e1>", ")", "or", "low", "(", "C1416801#ent", "<e2>", ")", "blood", "pressure", "study", "blood", "pressure-atherosclerosis", "interaction", "."], "h": {"id": "C1415507", "name": "C1415507#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1416801", "name": "C1416801#ent", "pos": [21, 22]}}
{"token": ["C1414057#ent", "<e1>", ",", "a", "Wnt", "inhibitor", "mediator", "of", "hMSC", "proliferation", ",", "is", "C3889446#ent", "<e2>", "in", "MFH", "."], "h": {"id": "C1414057", "name": "C1414057#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [12, 13]}}
{"token": ["C1562036#ent", "<e1>", "Verapamil", ")", "as", "well", "as", "drugs", "which", "reduce", "heart", "rate", "C0102151#ent", "<e2>", ",", "Propranolol", ")", "do", "not", "change", "the", "relation", "between", "ST", "depression", "and", "heart", "rate", "a", "given", "patient", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0102151", "name": "C0102151#ent", "pos": [12, 13]}}
{"token": ["C1417143#ent", "<e1>", "increased", "strongly", "the", "expression", "of", "the", "defence-related", "genes", "C0007965#ent", "<e2>", ",", "GST", ",", "PAL", "and", "PR-1", "."], "h": {"id": "C1417143", "name": "C1417143#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007965", "name": "C0007965#ent", "pos": [10, 11]}}
{"token": ["Patients", "with", "recent", "myocardial", "infarction", "apparent", "collateralization", "of", "the", "C0398738#ent", "<e1>", ",", "myocardial", "failure", "sinoatrial", "or", "C0151517#ent", "<e2>", "severe", "hepatic", "disease", "or", "renal", "failure", "excluded", "from", "the", "study", "."], "h": {"id": "C0398738", "name": "C0398738#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151517", "name": "C0151517#ent", "pos": [16, 17]}}
{"token": ["Patients", "with", "documented", "sustained", "ventricular", "tachycardia", "VT", ")", "or", "ventricular", "fibrillation", "C0042510#ent", "<e1>", ")", "who", "had", "their", "clinical", "arrhythmia", "inducible", "at", "baseline", "electrophysiologic", "study", "C0037707#ent", "<e2>", "320", "to", "640", "mg/day", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0037707", "name": "C0037707#ent", "pos": [24, 25]}}
{"token": ["One", "patient", "died", "2", "weeks", "after", "surviving", "cardiac", "arrest", "to", "intractable", "C0042510#ent", "<e1>", "while", "receiving", "C0037707#ent", "<e2>", "treatment", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0037707", "name": "C0037707#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "we", "prepared", "properly", "assembled", ",", "fully", "functional", "human", "E2", "that", "mediated", "enhanced", "regulatory", "enzyme", "activities", "but", ",", "lacking", "C1427500#ent", "<e1>", ",", "supported", "low", "C1335199#ent", "<e2>", "activity", "."], "h": {"id": "C1427500", "name": "C1427500#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1335199", "name": "C1335199#ent", "pos": [25, 26]}}
{"token": ["Recently", ",", "C1512076#ent", "<e1>", "DNA", "topoisomerase", "I", "inhibitors", "10-hydroxycamptothecin", "HCPT", ")", "and", "C0594375#ent", "<e2>", "(", "CPT", ")", "have", "been", "shown", "to", "have", "therapeutic", "effects", "both", "in", "vitro", "in", "vivo", "models", "of", "human", "breast", "cancer"], "h": {"id": "C1512076", "name": "C1512076#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "there", "was", "another", "C1334043#ent", "<e1>", "C1705011#ent", "<e2>", "-", "2", ")", "located", "in", "front", "of", "C1705011#ent", "<e2>", "in", "a", "head-to-head", "fashion", "and", "they", "shared", "a", "single", "promoter", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705011", "name": "C1705011#ent", "pos": [7, 8]}}
{"token": ["The", "clinical", "expression", "the", "disease", "is", "characterized", "by", "acute", ",", "life-threatening", "attacks", "of", "'", "porphyric", "neuropathy", "that", "include", "C0000737#ent", "<e1>", "motor", "and", "sensory", "neurological", "deficits", "C0233401#ent", "<e2>"], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0233401", "name": "C0233401#ent", "pos": [25, 26]}}
{"token": ["Patients", "with", "obesity", ",", "hirsutism", ",", "problems", "of", "external", "genitalia", ",", "enuresis", "nocturna", "C0000737#ent", "<e1>", "chest", "pain", "and", "lack", "of", "weight", "gain", "C0233401#ent", "<e2>", "pathological", "levels"], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0233401", "name": "C0233401#ent", "pos": [22, 23]}}
{"token": ["Loperamide", ",", "a", "novel", "antidiarrheal", "agent", "was", "compared", "with", "C0282145#ent", "<e1>", "in", "a", "double", "blind", "crossover", "study", "23", "patients", "with", "C0011991#ent", "<e2>", "various", "etiologies", "."], "h": {"id": "C0282145", "name": "C0282145#ent", "pos": [9, 10]}, "relation": "may_prevent", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [20, 21]}}
{"token": ["This", "was", "the", "result", "of", "cyclin", "E/CDK2", "interfering", "with", "the", "interaction", "of", "C1706440#ent", "<e1>", "with", "HDAC1", "and", "reducing", "C1422386#ent", "<e2>", "activity", "."], "h": {"id": "C1706440", "name": "C1706440#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1422386", "name": "C1422386#ent", "pos": [18, 19]}}
{"token": ["The", "C1337113#ent", "<e1>", "SWI/SNF", ")", "complex", "subunits", "BRM", "and", "C0812273#ent", "<e2>", "are", "highly", "conserved", "with", "direct", "counterparts", "in", "yeast", "(", "SWI2/SNF2", "and", "SNF5", ")", "and", "mammals", "(", "BRG1/hBRM", "and", "INI1/hSNF5", ")", "."], "h": {"id": "C1337113", "name": "C1337113#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812273", "name": "C0812273#ent", "pos": [9, 10]}}
{"token": ["C0019880#ent", "<e1>", "is", "a", "common", "inherited", "C0238621#ent", "<e2>", "resulting", "in", "nephrolithiasis", "."], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0238621", "name": "C0238621#ent", "pos": [6, 7]}}
{"token": ["C1335278#ent", "<e1>", "was", "evident", "in", "two", "C1417679#ent", "<e2>", ":", "a", "polymorphism", "in", "Acp33A", "associated", "with", "P1", "'", "and", "P2", "'", "and", "a", "polymorphism", "in", "CG17331", "associated", "with", "elevated", "P2", "'", "and", "reduced", "refractoriness", "."], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "C1414874#ent", "<e1>", "upregulated", "the", "nuclear", "translocation", "nuclear", "factor-kappa", "B", "the", "expression", "of", "c-myc-mRNA", "in", "C1416867#ent", "<e2>", ",", "HM", "and", "HF", "."], "h": {"id": "C1414874", "name": "C1414874#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [17, 18]}}
{"token": ["We", "thus", "hypothesized", "that", "impaired", "function", "of", "C1418440#ent", "<e1>", "might", "be", "associated", "with", "increased", "anxiety", "and", "concomitant", "C0243051#ent", "<e2>", "changes", "."], "h": {"id": "C1418440", "name": "C1418440#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [17, 18]}}
{"token": ["This", "study", "investigated", "the", "nonspecific", "immunomodulatory", "effects", "Bacillus", "Calmette-Guerin", "BCG", ")", ",", "muramyl", "dipeptide", "C1414134#ent", "<e1>", ")", "and", "ascorbic", "acid", "vitamin", "C", "on", "C0035690#ent", "<e2>", "the", "respiratory", "tract", "Fischer-344", "rats", "."], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035690", "name": "C0035690#ent", "pos": [23, 24]}}
{"token": ["The", "resistance", "percentages", "of", "C3273545#ent", "<e1>", "and", "PMU", "for", "neomycin", ",", "gentamicin", ",", "spectinomycin", ",", "C0060493#ent", "<e2>", ",", "enrofloxacin", ",", "and", "chloramphenicol", "varied", "from", "2", "%", "to", "16", "%", "."], "h": {"id": "C3273545", "name": "C3273545#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060493", "name": "C0060493#ent", "pos": [15, 16]}}
{"token": ["In", "2004", ",", "LRRK2", "was", "identified", "as", "the", "causative", "gene", "C1846862#ent", "<e1>", "originally", "mapped", "in", "the", "large", "Japanese", "Sagamihara", "family", "with", "C1854065#ent", "<e2>", "ADPD", ")", "."], "h": {"id": "C1846862", "name": "C1846862#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1854065", "name": "C1854065#ent", "pos": [21, 22]}}
{"token": ["Antithrombin", "III", "AT", "III", "is", "an", "inhibitor", "of", "C0036734#ent", "<e1>", "serpin", ")", "comprising", "432", "C3539947#ent", "<e2>"], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [14, 15]}}
{"token": ["This", "study", "demonstrates", "that", "light", "exposure", "the", "subjective", "night", "opposite", "effects", "on", "the", "expression", "of", "the", "clock", "genes", "C1418464#ent", "<e1>", "and", "Per2", "compared", "with", "that", "of", "C3813555#ent", "<e2>", "."], "h": {"id": "C1418464", "name": "C1418464#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3813555", "name": "C3813555#ent", "pos": [26, 27]}}
{"token": ["c-and", "C0812289#ent", "<e1>", "expression", "were", "observed", "that", "anti", "pan-Myc", "antibody", "C0079068#ent", "<e2>", "and", "N-Myc", "proteins", "not", "L-Myc", "."], "h": {"id": "C0812289", "name": "C0812289#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [10, 11]}}
{"token": ["In", "the", "U-266", "MM", "cell", "line", ",", "C0812289#ent", "<e1>", ",", "but", "no", "C0079068#ent", "<e2>", "mRNA", "or", "protein", ",", "was", "found", "."], "h": {"id": "C0812289", "name": "C0812289#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [12, 13]}}
{"token": ["A", "Max", "expression", "vector", "was", "found", "to", "augment", "the", "cotransforming", "activity", "of", "C0812289#ent", "<e1>", "as", "well", "as", "that", "of", "C0079068#ent", "<e2>", "."], "h": {"id": "C0812289", "name": "C0812289#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [19, 20]}}
{"token": ["C1366489#ent", "<e1>", "was", "induced", "by", "using", "C0302363#ent", "<e2>", "endotoxin", "as", "the", "antigen", "and", "rabbit", "anti-Brucella", "endotoxin", "antisera", "."], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0302363", "name": "C0302363#ent", "pos": [6, 7]}}
{"token": ["Three", "mutant", "C0002085#ent", "<e1>", "of", "arf", "were", "constructed", "and", "installed", "in", "C1825005#ent", "<e2>", "in", "place", "of", "the", "wild-type", "allele", ":", "an", "out-of-frame", "internal", "deletion", "an", "in-frame", "internal", "deletion", ",", "and", "an", "amber", "mutation"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1825005", "name": "C1825005#ent", "pos": [11, 12]}}
{"token": ["This", "possibility", "has", "been", "examined", "using", "the", "C0003211#ent", "<e1>", "ibuprofen", ",", "ketoprofen", ",", "C0059865#ent", "<e2>", "and", "flurbiprofen", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [7, 8]}, "relation": "structural_class_of", "t": {"id": "C0059865", "name": "C0059865#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "the", "ability", "of", "three", "C0003211#ent", "<e1>", "(", "indomethacin", ",", "loxoprofen", ",", "and", "C0059865#ent", "<e2>", ")", "to", "eliminate", "and", "inhibit", "free", "radicals"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [6, 7]}, "relation": "structural_class_of", "t": {"id": "C0059865", "name": "C0059865#ent", "pos": [14, 15]}}
{"token": ["A", "reduced", "incidence", "of", "gastropathy", "has", "been", "observed", "among", "newly", "developed", "C0003211#ent", "<e1>", "such", "as", "C0059865#ent", "<e2>", "and", "the", "non-acidic", "nabumetone"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [11, 12]}, "relation": "structural_class_of", "t": {"id": "C0059865", "name": "C0059865#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "the", "improved", "tolerability", "of", "2", "other", "new", "C0003211#ent", "<e1>", ",", "nabumetone", "and", "C0059865#ent", "<e2>", ",", "has", "been", "established", "in", "clinical", "trials", "limited", "postmarketing", "surveillance"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}, "relation": "structural_class_of", "t": {"id": "C0059865", "name": "C0059865#ent", "pos": [15, 16]}}
{"token": ["Expression", "of", "enzymes", "involved", "in", "ceramide", "generation", "neutral", "sphingomyelinase", "NSMase", "]", ",", "acid", "sphingomyelinase", "ASMase", "]", ",", "and", "C4284028#ent", "<e1>", "[", "SPT", "]", ")", "and", "ceramide", "hydrolysis", "C0109060#ent", "<e2>", ")", "are", "elevated", "in", "obese", "adipose", "tissues"], "h": {"id": "C4284028", "name": "C4284028#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0109060", "name": "C0109060#ent", "pos": [27, 28]}}
{"token": ["The", "hypochromic", ",", "C0002886#ent", "<e1>", "the", "most", "frequently", "encountered", "C0002871#ent", "<e2>", "on", "a", "world-wide", "scale", ",", "with", "iron", "deficiency", "anemia", "ranking", "as", "the", "commonest", "."], "h": {"id": "C0002886", "name": "C0002886#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [9, 10]}}
{"token": ["While", "folic", "acid", "deficiency", "C0002886#ent", "<e1>", "non-renal", "patients", ",", "the", "relevance", "of", "altered", "folate", "metabolism", "C0002871#ent", "<e2>", "of", "end-stage", "renal", "disease", "its", "response", "to", "rHu-EPO", "is", "less", "clear", "."], "h": {"id": "C0002886", "name": "C0002886#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [15, 16]}}
{"token": ["The", "study", "results", "show", "that", "C0546862#ent", "<e1>", "nitrate", "cream", "a", "valuable", "C1254351#ent", "<e2>", "for", "the", "treatment", "of", "tinea", "versicolor"], "h": {"id": "C0546862", "name": "C0546862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}}
{"token": ["The", "relative", "abundance", "of", "the", "mitochondrial-encoded", "mRNAs", "for", "C0760197#ent", "<e1>", "NADH", "dehydrogenase", "subunit", "I", "was", "lower", "in", "brown", "adipose", "tissue", "C1412726#ent", "<e2>", ")", "from", "lactating", "rats", "than", "in", "virgin", "controls", "."], "h": {"id": "C0760197", "name": "C0760197#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [20, 21]}}
{"token": ["This", "C0207564#ent", "<e1>", "was", "inhibited", "by", "p-chloromercuribenzonate", "(", "C0008249#ent", "<e2>", ")", "and", "leupeptin", "more", "efficiently", "than", "by", "aprotinin", "."], "h": {"id": "C0207564", "name": "C0207564#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008249", "name": "C0008249#ent", "pos": [8, 9]}}
{"token": ["We", "identified", "16", "methylated", "C1417679#ent", "<e1>", ",", "including", "many", "novel", "C1417679#ent", "<e1>", ",", "in", "DGC", "cell", "lines", "studied", "C1436157#ent", "<e1>", "with", "particular", "interest", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1436157", "name": "C1436157#ent", "pos": [18, 19]}}
{"token": ["The", "down-regulated", "genes", "include", "C1417679#ent", "<e1>", "that", "encode", "subunits", "of", "complex", "I", "the", "Parkinson's-disease-linked", "C1436157#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1436157", "name": "C1436157#ent", "pos": [14, 15]}}
{"token": ["Chlamydophila", "pneumoniae", "one", "of", "the", "most", "common", "C0991617#ent", "<e1>", "of", "atypical", "C0206171#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0206171", "name": "C0206171#ent", "pos": [11, 12]}}
{"token": ["Not", "surprisingly", ",", "different", "guidelines", "have", "inserted", "these", "C0991617#ent", "<e1>", "among", "the", "drugs", "of", "choice", "in", "the", "empirical", "therapy", "C0206171#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0206171", "name": "C0206171#ent", "pos": [19, 20]}}
{"token": ["This", "review", "briefly", "examines", "new", "evidence", "for", "physiologic", "and", "pathologic", "roles", "K(+", ")", "channels", ",", "the", "renin-angiotensin", "system", "reactive", "oxygen", "species", "and", "Rho", "and", "C0389995#ent", "<e1>", "in", "regulation", "of", "C0007820#ent", "<e2>"], "h": {"id": "C0389995", "name": "C0389995#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [29, 30]}}
{"token": ["C1334889#ent", "<e1>", "activity", "is", "essential", "for", "the", "specification", "of", "T-lineage", "C1539479#ent", "<e2>", "in", "hematopoietic", "progenitors"], "h": {"id": "C1334889", "name": "C1334889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [10, 11]}}
{"token": ["C0795907#ent", "<e1>", "is", "characterized", "by", "high", "levels", "of", "C1415975#ent", "<e2>", "in", "the", "atopic", "patient's", "serum", ",", "and", "the", "presence", "of", "allergic", "mucin", "contains", "eosinophils", "and", "fungal", "components", "."], "h": {"id": "C0795907", "name": "C0795907#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [8, 9]}}
{"token": ["Among", "the", "extrinsic", "tumours", "there", "was", "one", "pituitary", "macroadenoma", "C0221169#ent", "<e1>", "and", "four", "meningiomas", "with", "C0242422#ent", "<e2>", "."], "h": {"id": "C0221169", "name": "C0221169#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [15, 16]}}
{"token": ["In", "a", "case", "of", "C0221169#ent", "<e1>", "following", "thalamotomy", "for", "C0242422#ent", "<e2>", ",", "detailed", "anatomical", "studies", "showed", "bilateral", "cortical", "pseudolaminar", "necrosis", "and", "no", "involvement", "of", "the", "subthalamic", "nuclei", "the", "thalamic", "lesions"], "h": {"id": "C0221169", "name": "C0221169#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [9, 10]}}
{"token": ["Neuroimmune", "interactions", "at", "C0021832#ent", "<e1>", "been", "associated", "with", "pathophysiology", "of", "infectious", "and", "enterotoxin-mediated", "diarrhea", "and", "C0029191#ent", "<e2>", "including", "inflammatory", "bowel", "disease", "IBD", ")", "."], "h": {"id": "C0021832", "name": "C0021832#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029191", "name": "C0029191#ent", "pos": [15, 16]}}
{"token": ["The", "localization", "of", "both", "PAR-3", "and", "C1335190#ent", "<e1>", "affected", "identically", "by", "mutations", "in", "the", "C0812264#ent", "<e2>", ",", "par-4", "and", "par-5", "genes", "."], "h": {"id": "C1335190", "name": "C1335190#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812264", "name": "C0812264#ent", "pos": [14, 15]}}
{"token": ["A", "51-year-old", "man", "was", "C0275626#ent", "<e1>", "by", "the", "C1705504#ent", "<e2>", "of", "a", "broomstick", "weighing", "1000", "g", "at", "the", "left", "side", "of", "the", "neck", ",", "upon", "which", "he", "collapsed", "."], "h": {"id": "C0275626", "name": "C0275626#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705504", "name": "C1705504#ent", "pos": [8, 9]}}
{"token": ["After", "growth", "on", "oleate", "there", "was", "nearly", "a", "10-fold", "induction", "of", "the", "acyl", "coenzyme", "A", "CoA", ")", "C0023689#ent", "<e1>", "and", "a", "fivefold", "increase", "in", "the", "activity", "of", "the", "C0085889#ent", "<e2>"], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085889", "name": "C0085889#ent", "pos": [28, 29]}}
{"token": ["Optimal", "Ass", "generation", "in", "vitro", "achieved", "at", "mildly", "acidic", "pH", "and", "could", "be", "inhibited", "by", "the", "aspartyl", "protease", "inhibitor", "pepstatin", "A", ",", "consistent", "with", "suggestion", "that", "C0379528#ent", "<e1>", "is", "an", "C0078989#ent", "<e2>"], "h": {"id": "C0379528", "name": "C0379528#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0078989", "name": "C0078989#ent", "pos": [30, 31]}}
{"token": ["Similar", "to", "C0379528#ent", "<e1>", ",", "presenilinase", "seems", "to", "be", "an", "C0078989#ent", "<e2>", "as", "C0078989#ent", "<e2>", "pepstatin", "A", "is", "the", "most", "potent", "inhibitor", "toward", "presenilinase", "among", "different", "classes", "of", "protease", "inhibitors"], "h": {"id": "C0379528", "name": "C0379528#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0078989", "name": "C0078989#ent", "pos": [10, 11]}}
{"token": ["Overexpression", "of", "Wnt-5a", "or", "treatment", "with", "C1710291#ent", "<e1>", "stimulated", "the", "activation", "of", "C1565919#ent", "<e2>", "PKC-alpha", ")", "and", "p38", "mitogen-activated", "protein", "kinase", "MAPK", ")", ",", "both", "positive", "regulators", "of", "chondrogenic", "differentiation"], "h": {"id": "C1710291", "name": "C1710291#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1565919", "name": "C1565919#ent", "pos": [12, 13]}}
{"token": ["This", "problem", "is", "typified", "by", "the", "difficulty", "of", "classification", "and", "differentiation", "of", "two", "prototypic", "C0004364#ent", "<e1>", "Systemic", "Lupus", "Erythematosus", "SLE", ")", "and", "Mixed", "Connective", "Tissue", "Disease", "C0026272#ent", "<e2>", ")", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0026272", "name": "C0026272#ent", "pos": [26, 27]}}
{"token": ["Pretreatment", "with", "6-(2-propargyloxyphenyl", ")", "hexanoic", "acid", "(", "C1706339#ent", "<e1>", "50", "microM", ")", ",", "an", "epoxygenase", "inhibitor", "or", "the", "C0669516#ent", "<e2>", "Tempol", "(", "100", "microM", ")", "significantly", "attenuated", "acrolein-induced", "vasodilatation", "."], "h": {"id": "C1706339", "name": "C1706339#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [18, 19]}}
{"token": ["However", ",", "we", "have", "recently", "described", "a", "reactive", "mechanism", "protection", "of", "tumour", "cells", "the", "apoptosis", "induced", "by", "C1708406#ent", "<e1>", "dependent", "on", "the", "epidermal", "growth", "factor", "Ras/extracellular", "signal", "regulated", "kinase", "C1705791#ent", "<e2>", ")", "signalling", "."], "h": {"id": "C1708406", "name": "C1708406#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [29, 30]}}
{"token": ["When", "C1708406#ent", "<e1>", "induced", "apoptosis", ",", "a", "hyperactivation", "of", "MEK-1", "and", "C1705791#ent", "<e2>", "signalling", "and", "a", "decrease", "of", "the", "hypusine-containing", "form", "and", ",", "thus", ",", "of", "eIF-5A", "activity", "were", "recorded", "."], "h": {"id": "C1708406", "name": "C1708406#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [11, 12]}}
{"token": ["This", "C1848862#ent", "<e1>", "can", "result", "from", "C1420654#ent", "<e2>", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420654", "name": "C1420654#ent", "pos": [6, 7]}}
{"token": ["This", "is", "the", "second", "genetically", "confirmed", "case", "revealing", "the", "previously", "described", "association", "of", "PHS", "with", "C0269209#ent", "<e1>", "due", "to", "vaginal", "atresia", "a", "clinical", "overlap", "C0948368#ent", "<e2>", "."], "h": {"id": "C0269209", "name": "C0269209#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0948368", "name": "C0948368#ent", "pos": [24, 25]}}
{"token": ["Together", ",", "these", "results", "suggest", "that", "C0052456#ent", "<e1>", "accumulation", "rather", "than", "C0023195#ent", "<e2>", "responsible", "for", "the", "barrier", "abnormality"], "h": {"id": "C0052456", "name": "C0052456#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023195", "name": "C0023195#ent", "pos": [11, 12]}}
{"token": ["Studies", "with", "mammalian", "overexpression", "systems", "that", "both", "C0812228#ent", "<e1>", "association", "and", "oligomerization", "domains", "C2985257#ent", "<e2>", "are", "distinct", "functional", "domains"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2985257", "name": "C2985257#ent", "pos": [13, 14]}}
{"token": ["We", "recently", "reported", "preliminary", "evidence", "that", "C2699890#ent", "<e1>", "tandospirone", ")", ",", "a", "5-HT1A", "agonist", "improved", "cerebellar", "ataxia", "patients", "with", "C4019432#ent", "<e2>", "MJD", ")", "."], "h": {"id": "C2699890", "name": "C2699890#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4019432", "name": "C4019432#ent", "pos": [19, 20]}}
{"token": ["Human", "C0534137#ent", "<e1>", "CYP2B6", ")", "metabolizes", "the", "prodrug", "cyclophosphamide", "CPA", ")", "to", "produce", "C0064039#ent", "<e2>", "cross-links", "DNA", "to", "cell", "death"], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0064039", "name": "C0064039#ent", "pos": [13, 14]}}
{"token": ["Preliminary", "structural", "studies", "by", "using", "radioimmunoprecipitation", "and", "sodium", "dodecyl", "sulfate", "polyacrylamide", "gel", "electrophoresis", "that", "C2987232#ent", "<e1>", "recognizes", "a", "two-chain", "polypeptide", "of", "approximately", "170", "kilodaltons", "(", "C1705240#ent", "<e2>", ")", "and", "95", "C1705240#ent", "<e2>", "under", "reducing", "conditions", "."], "h": {"id": "C2987232", "name": "C2987232#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [25, 26]}}
{"token": ["We", "have", "been", "interested", "in", "the", "findings", "of", "abnormal", "increases", "in", "the", "numbers", "of", "small", "vessels", "specimens", "of", "C1562113#ent", "<e1>", "resected", "from", "C0014544#ent", "<e2>", "patients", "."], "h": {"id": "C1562113", "name": "C1562113#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [22, 23]}}
{"token": ["C0290149#ent", "<e1>", "consists", "of", "kringle", "domains", "1", "4", "and", "part", "of", "kringle", "5", "while", "C0066522#ent", "<e2>", "consists", "of", "the", "remainder", "of", "kringle", "5", "the", "serine", "proteinase", "domain"], "h": {"id": "C0290149", "name": "C0290149#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0066522", "name": "C0066522#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "ET-1", "may", "foster", "asymptomatic", "lacunar", "cerebral", "infarcts", "promoting", "C0577631#ent", "<e1>", "patients", "with", "C0155583#ent", "<e2>"], "h": {"id": "C0577631", "name": "C0577631#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [14, 15]}}
{"token": ["Further", "evidence", "that", "the", "synthesis", "of", "C4084890#ent", "<e1>", "was", "not", "directly", "affected", "was", "obtained", "using", "the", "C0907533#ent", "<e2>", "active", "R2C", "cells", "."], "h": {"id": "C4084890", "name": "C4084890#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [16, 17]}}
{"token": ["DNA-binding", "competition", "is", "a", "putative", "mechanism", "of", "such", "dominant", "negative", "effects", "of", "AML1/Evi-1", "because", "it", "binds", "to", "C1332671#ent", "<e1>", "sites", "with", "higher", "affinity", "than", "C1705326#ent", "<e2>", "does", "."], "h": {"id": "C1332671", "name": "C1332671#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705326", "name": "C1705326#ent", "pos": [24, 25]}}
{"token": ["The", "carboxy-terminal", "domain", "RIP3", ",", "like", "that", "of", "C1826849#ent", "<e1>", ",", "could", "activate", "the", "C1417708#ent", "<e2>", "induce", "apoptosis", "when", "expressed", "in", "mammalian", "cells"], "h": {"id": "C1826849", "name": "C1826849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [14, 15]}}
{"token": ["Autoantibodies", "to", "HMG-17", ",", "a", "non-histone", "nucleosomal", "protein", "were", "found", "in", "systemic", "lupus", "erythematosus", "SLE", ")", ",", "mixed", "connective", "tissue", "disease", "MCTD", ")", "and", "ANA", "positive", "C0157917#ent", "<e1>", "JRA", ")", ",", "but", "not", "in", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0157917", "name": "C0157917#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [34, 35]}}
{"token": ["Both", "are", "prevalent", "among", "geriatric", "patients", ",", "and", "can", "present", "as", "C0157917#ent", "<e1>", "or", "as", "a", "chronic", "polyarthropathy", "resembling", "osteoarthritis", "or", "C0038013#ent", "<e2>"], "h": {"id": "C0157917", "name": "C0157917#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [21, 22]}}
{"token": ["The", "C0042071#ent", "<e1>", "uPA", ")", "system", "and", "the", "mannan-binding", "lectin", "C0065661#ent", "<e2>", ")", "complement", "activation", "pathway", "involved", "in", "regulation", "of", "immune", "responses"], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0065661", "name": "C0065661#ent", "pos": [10, 11]}}
{"token": ["C0030956#ent", "<e1>", "were", "assayed", "for", "in", "vitro", "inhibition", "of", "C0268060#ent", "<e2>", "production", "in", "Diploptera", "punctata", "Periplaneta", "americana"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268060", "name": "C0268060#ent", "pos": [9, 10]}}
{"token": ["We", "have", "also", "determined", "the", "relative", "potency", "of", "the", "same", "C0030956#ent", "<e1>", "to", "inhibit", "C0268060#ent", "<e2>", "synthesis", "in", "corpora", "allata"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268060", "name": "C0268060#ent", "pos": [14, 15]}}
{"token": ["This", "C0030956#ent", "<e1>", "strongly", "stimulates", "the", "synthesis", "and", "release", "of", "juvenile", "hormone", "C0268060#ent", "<e2>", ")", "in", "vitro", "the", "corpora", "allata", "CA", ")", "of", "S.", "frugiperda", "and", "was", "code-named", "Spofr-AT", "2", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268060", "name": "C0268060#ent", "pos": [12, 13]}}
{"token": ["One", "group", "of", "these", "C0030956#ent", "<e1>", ",", "termed", "allatostatins", ",", "reversibly", "inhibits", "the", "biosynthesis", "of", "C0268060#ent", "<e2>", "in", "vitro"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268060", "name": "C0268060#ent", "pos": [15, 16]}}
{"token": ["We", "recently", "identified", "a", "new", "human", "gene", "family", "encoding", "large", "C0021699#ent", "<e1>", "sex/plexins", ",", "sharing", "homologies", "with", "C1822773#ent", "<e2>", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1822773", "name": "C1822773#ent", "pos": [17, 18]}}
{"token": ["we", "determined", "the", "effect", "on", "C0006109#ent", "<e1>", "long-term", "administration", "of", "Enterococcus", "faecium", "SF68", ")", "versus", "C0022957#ent", "<e2>", "."], "h": {"id": "C0006109", "name": "C0006109#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022957", "name": "C0022957#ent", "pos": [15, 16]}}
{"token": ["Clinical", "effectiveness", "lactitol", ",", "in", "long-term", "treatment", "of", "C0006109#ent", "<e1>", "is", "similar", "to", "those", "of", "C0022957#ent", "<e2>", "."], "h": {"id": "C0006109", "name": "C0006109#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022957", "name": "C0022957#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "severe", "C1839163#ent", "<e1>", "in", "two", "adult", "patients", "preceded", "by", "C0740380#ent", "<e2>", "Epstein-Barr", "virus", "infection", "respectively", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0740380", "name": "C0740380#ent", "pos": [11, 12]}}
{"token": ["Inclusion", "of", "risk", "factors", "CHD", "in", "the", "model", "showed", "the", "same", "trend", ",", "although", "not", "significant", "for", "C0011860#ent", "<e1>", "(", "P=0.01", "for", "C1417332#ent", "<e2>", ",", "and", "P=0.06", "for", "C0011860#ent", "<e1>", ")", "."], "h": {"id": "C1417332", "name": "C1417332#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [17, 18]}}
{"token": ["Overexpression", "of", "C0812235#ent", "<e1>", "renders", "cells", "hypersensitive", "to", "the", "killing", "effect", "of", "alkylating", "agents", "C0282559#ent", "<e2>", "not", "to", "UV-light", "and", "doxorubicin", "."], "h": {"id": "C0812235", "name": "C0812235#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0282559", "name": "C0282559#ent", "pos": [14, 15]}}
{"token": ["The", "excess", "IGFBP-2", "and", "-1", "may", "play", "a", "role", "in", "the", "C0015544#ent", "<e1>", "CRF", "children", "by", "sequestering", "IGF", "C0030956#ent", "<e2>", "."], "h": {"id": "C0015544", "name": "C0015544#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}}
{"token": ["C0011884#ent", "<e1>", "severe", "glaucoma", ",", "C0035309#ent", "<e2>", "chorioretinal", "diseases", "also", "important", "blindness", "causes", "."], "h": {"id": "C0011884", "name": "C0011884#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0035309", "name": "C0035309#ent", "pos": [5, 6]}}
{"token": ["Here", "we", "report", "on", "the", "effect", "of", "17", "C0014914#ent", "<e1>", "on", "the", "synthesis", "of", "PGI2", "and", "C3273436#ent", "<e2>", "in", "cultured", "human", "umbilical", "vein", "endothelial", "cells"], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [16, 17]}}
{"token": ["17", "C0014914#ent", "<e1>", "produced", "dose-dependent", "relaxation", "of", "coronary", "microvessels", "preconstricted", "with", "C3273436#ent", "<e2>", "that", "was", "similar", "to", "the", "response", "to", "testosterone", "and", "progesterone", "."], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "novel", "C0991617#ent", "<e1>", "targeting", "the", "pre-existing", "NSCLC", "vasculature", "(", "i.e.", "vascular", "disrupting", "agents", "C1710595#ent", "<e2>", ")", "or", "multiple", "tyrosine", "kinase", "inhibitors", "emerged", "as", "unique", "drug", "classes", "promising", "results", "in", "several", "preclinical", "and", "clinical", "studies"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1710595", "name": "C1710595#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "case", "of", "acute", "papillary", "muscle", "rupture", "associated", "with", "intercurrent", "Campylobacter", "jejuni", "C0152517#ent", "<e1>", "in", "a", "child", "with", "a", "diagnosis", "of", "C1863844#ent", "<e2>", ",", "requiring", "urgent", "mitral", "valve", "replacement"], "h": {"id": "C0152517", "name": "C0152517#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1863844", "name": "C1863844#ent", "pos": [23, 24]}}
{"token": ["Tolerability", "of", "C1425467#ent", "<e1>", "is", "satisfactory", ",", "better", "than", "for", "conventional", "C0005064#ent", "<e2>", "."], "h": {"id": "C1425467", "name": "C1425467#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [11, 12]}}
{"token": ["The", "high-flux", "membrane", "had", "an", "ultrafiltration", "rate", "of", "15", "ml/h/mm", "Hg", "transmembrane", "pressure", ",", "a", "C1417635#ent", "<e1>", "clearance", "of", "88", "ml/min", "and", "a", "C1412709#ent", "<e2>", "clearance", "of", "11.4", "ml/min", "."], "h": {"id": "C1417635", "name": "C1417635#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412709", "name": "C1412709#ent", "pos": [23, 24]}}
{"token": ["On", "the", "other", "hand", ",", "the", "LTP", "in", "the", "lateral", "amygdala", "not", "affected", "by", "C0000254#ent", "<e1>", ",", "but", "was", "significantly", "reduced", "by", "C0036442#ent", "<e2>", "."], "h": {"id": "C0000254", "name": "C0000254#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [22, 23]}}
{"token": ["Both", "normal", "and", "C1710605#ent", "<e1>", "canine", "platelet", "MPs", "contained", "three", "major", "C0072522#ent", "<e2>", "as", "well", "as", "four", "smaller-molecular-weight", "proteins", "that", "stained", "for", "carbohydrate", "with", "the", "PAS", "reagent"], "h": {"id": "C1710605", "name": "C1710605#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [11, 12]}}
{"token": ["Persistent", "C0020480#ent", "<e1>", "is", "accompanied", "by", "raised", "concentrations", "of", "C0015518#ent", "<e2>", "factor", "IX", "factor", "VII", "prothrombin", "."], "h": {"id": "C0020480", "name": "C0020480#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015518", "name": "C0015518#ent", "pos": [9, 10]}}
{"token": ["C1259877#ent", "<e1>", "phosphorylation", "of", "cardiac", "troponin", "I", "C3538828#ent", "<e2>", ")", "and", "troponin", "T", "cTnT", ")", "has", "been", "shown", "to", "diminish", "maximum", "activation", "of", "myofilaments", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538828", "name": "C3538828#ent", "pos": [7, 8]}}
{"token": ["It", "is", "concluded", "that", "C0031007#ent", "<e1>", "and", "terguride", "show", "a", "high", "affinity", "for", "C1708300#ent", "<e2>", "but", "dimerization", "(", "oligomerization", ")", "of", "both", "drugs", "fails", "to", "increase", "affinity", "."], "h": {"id": "C0031007", "name": "C0031007#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1708300", "name": "C1708300#ent", "pos": [13, 14]}}
{"token": ["To", "further", "evaluate", "the", "biological", "role", "of", "C0389925#ent", "<e1>", ",", "we", "expressed", "the", "C0014442#ent", "<e2>", "in", "bacterial", "and", "viral", "expression", "systems"], "h": {"id": "C0389925", "name": "C0389925#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "the", "acid", "beta-glucuronidase", "gene", "to", "systemic", "accumulation", "of", "undegraded", "C3536869#ent", "<e1>", "in", "lysosomes", "and", "ultimately", "to", "clinical", "manifestations", "C0796079#ent", "<e2>", "Sly", "disease", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0796079", "name": "C0796079#ent", "pos": [20, 21]}}
{"token": ["beta-Glucuronidase", "levels", "and", "C3536869#ent", "<e1>", "accumulation", "were", "studied", "in", "normal", ",", "carrier", ",", "and", "C0796079#ent", "<e2>"], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0796079", "name": "C0796079#ent", "pos": [14, 15]}}
{"token": ["In", "the", "AIDS", "patient", ",", "cryptococcal", "meningitis", "presents", "with", "fever", "and", "C0270697#ent", "<e1>", "and", "is", "best", "treated", "with", "intravenous", "amphotericin", "B", "oral", "flucytosine", "or", "C0016277#ent", "<e2>", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [24, 25]}}
{"token": ["The", "presence", "of", "globoid", "cells", "may", "not", "be", "essential", "for", "the", "pathologic", "diagnosis", "C0023521#ent", "<e1>", "the", "presence", "of", "appropriate", "C0149676#ent", "<e2>"], "h": {"id": "C0023521", "name": "C0023521#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0149676", "name": "C0149676#ent", "pos": [19, 20]}}
{"token": ["The", "twitcher", "mouse", "is", "affected", "by", "a", "disease", "with", "pathological", "features", "resembling", "those", "of", "human", "globoid", "cell", "leucodystrophy", "C0023521#ent", "<e1>", ":", "it", "also", "has", "an", "identical", "C0149676#ent", "<e2>"], "h": {"id": "C0023521", "name": "C0023521#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0149676", "name": "C0149676#ent", "pos": [26, 27]}}
{"token": ["Type", "1", "diabetes", "mellitus", "DM", ")", "and", "C0339143#ent", "<e1>", "autoimmune", "diseases", "and", "a", "number", "of", "genetic", "factors", "including", "HLA", "and", "C1705969#ent", "<e2>", "have", "been", "reported", "to", "contribute", "to", "their", "etiology", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [20, 21]}}
{"token": ["The", "first", "manifestations", "of", "C0013384#ent", "<e1>", "are", "usually", "C1539312#ent", "<e2>", "and", "involve", "the", "foot", "homolateral", "to", "the", "side", "most", "affected", "by", "Parkinson's", "disease"], "h": {"id": "C0013384", "name": "C0013384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [8, 9]}}
{"token": ["Off", "'", "period", "C0013384#ent", "<e1>", "tend", "to", "be", "relatively", "fixed", ",", "painful", ",", "and", "C1539312#ent", "<e2>", "."], "h": {"id": "C0013384", "name": "C0013384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [14, 15]}}
{"token": ["Levels", "of", "IgE", "antibodies", "Staphylococcus", "aureus", "Staphylococcus", "epidermidis", "determined", "in", "eleven", "patients", "with", "typical", "atopic", "dermatitis", "with", "no", "history", "C0242301#ent", "<e1>", "or", "severe", "C0038160#ent", "<e2>"], "h": {"id": "C0242301", "name": "C0242301#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0038160", "name": "C0038160#ent", "pos": [23, 24]}}
{"token": ["Elevated", "circulating", "plasma", "nonesterified", "fatty", "acids", "C1417875#ent", "<e1>", ")", "may", "contribute", "to", "the", "insulin", "resistance", "hyperglycemia", "of", "non-insulin-dependent", "diabetes", "mellitus", "C0011860#ent", "<e2>", ")", ",", "and", "decreasing", "plasma", "C1417875#ent", "<e1>", "could", "provide", "a", "therapeutic", "benefit", "."], "h": {"id": "C1417875", "name": "C1417875#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [20, 21]}}
{"token": ["To", "assess", "the", "role", "of", "fasting", "plasma", "non-esterified", "fatty", "acids", "C1417875#ent", "<e1>", ")", "in", "the", "development", "of", "C0011860#ent", "<e2>", "NIDDM", ")", ",", "data", "were", "analysed", "from", "annual", "examinations", "of", "190", "non-diabetic", "Pima", "Indians"], "h": {"id": "C1417875", "name": "C1417875#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [17, 18]}}
{"token": ["The", "gene", "annotated", "in", "the", "Brucella", "abortus", "2308", "genome", "sequence", "predicted", "to", "encode", "a", "C1334043#ent", "<e1>", "of", "the", "well-characterized", "heme", "transporter", "ShuA", "of", "C0302358#ent", "<e2>", "accordingly", "has", "been", "given", "the", "designation", "bhuA", "(", "Brucella", "heme", "utilization", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0302358", "name": "C0302358#ent", "pos": [23, 24]}}
{"token": ["Among", "35", "elderly", "patients", "with", "transtracheal", "aspirate", "C0032285#ent", "<e1>", "7", "(", "20", "percent", ")", "had", "C0032269#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0032269", "name": "C0032269#ent", "pos": [15, 16]}}
{"token": ["The", "presence", "or", "absence", "of", "C0032285#ent", "<e1>", "or", "acute", "otitis", "media", "not", "significantly", "correlated", "with", "evidence", "of", "C0032269#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0032269", "name": "C0032269#ent", "pos": [17, 18]}}
{"token": ["Here", ",", "we", "report", "the", "first", "isolation", "and", "developmental", "characterization", "of", "a", "Drosophila", "C0062773#ent", "<e1>", "Dmel\\TIP60", ")", "that", "is", "the", "homolog", "of", "the", "human", "C1540026#ent", "<e2>", "gene", "TIP60", "."], "h": {"id": "C0062773", "name": "C0062773#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1540026", "name": "C1540026#ent", "pos": [24, 25]}}
{"token": ["These", "results", "indicate", "that", "the", "N-terminal", "regions", "of", "the", "beta", "and", "C1415155#ent", "<e1>", "lower", "the", "solubility", "of", "C0020239#ent", "<e2>"], "h": {"id": "C1415155", "name": "C1415155#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020239", "name": "C0020239#ent", "pos": [17, 18]}}
{"token": ["We", "report", "here", "a", "patient", "with", "C0004030#ent", "<e1>", "was", "successfully", "treated", "with", "C0393080#ent", "<e2>", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0393080", "name": "C0393080#ent", "pos": [12, 13]}}
{"token": ["Patients", "were", "categorized", "into", "groups", "with", "C0022104#ent", "<e1>", "iron-deficiency", "anemia", "B(12)/folate", "deficiency", ",", "and", "treated", "and", "untreated", "C0007570#ent", "<e2>"], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [17, 18]}}
{"token": ["Activation", "(", "by", "specific", "agonists", ")", "of", "A1", "or", "A3", "Ado", "receptors", "or", "C1826724#ent", "<e1>", "resulted", "in", "PC", "in", "C1425400#ent", "<e2>", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1425400", "name": "C1425400#ent", "pos": [19, 20]}}
{"token": ["We", "isolated", "a", "novel", "fusion", "transcript", "type", "variant", "involving", "the", "fusion", "of", "C1420439#ent", "<e1>", "with", "exon", "6", "the", "SSX4", "gene", "C3274713#ent", "<e2>", ")", "."], "h": {"id": "C1420439", "name": "C1420439#ent", "pos": [12, 13]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274713", "name": "C3274713#ent", "pos": [20, 21]}}
{"token": ["Further", "sixteen", "patients", "with", "stable", "C0264694#ent", "<e1>", "given", "100", "mg", "C0304348#ent", "<e2>", "per", "day", "."], "h": {"id": "C0264694", "name": "C0264694#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0304348", "name": "C0304348#ent", "pos": [10, 11]}}
{"token": ["C0162809#ent", "<e1>", "anosmia", ",", "related", "to", "defective", "olfactory", "bulb", "morphogenesis", ",", "and", "C0020619#ent", "<e2>", "due", "to", "gonadotropin-releasing", "hormone", "deficiency"], "h": {"id": "C0162809", "name": "C0162809#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0020619", "name": "C0020619#ent", "pos": [12, 13]}}
{"token": ["Its", "major", "psychoactive", "constituent", ",", "delta-9-tetrahydrocannabinol", "(", "C0039663#ent", "<e1>", ")", "was", "isolated", "in", "1964", "and", "first", "used", "to", "C0027497#ent", "<e2>", "vomiting", "during", "chemotherapy", "in", "the", "1970s", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0027497", "name": "C0027497#ent", "pos": [18, 19]}}
{"token": ["C1144403#ent", "<e1>", "(", "LY333328", "diphosphate", ")", "is", "a", "novel", "C0061642#ent", "<e2>", "antimicrobial", "agent", "with", "potent", "microbiological", "activity", "in", "vitro", "Gram-positive", "bacteria"], "h": {"id": "C1144403", "name": "C1144403#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0061642", "name": "C0061642#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "changes", "in", "the", "activity", "of", "several", "C3540790#ent", "<e1>", ",", "e.g.", ",", "cell", "wall", "invertase", "soluble", "invertase", ",", "C0060764#ent", "<e2>", "and", "phosphoglucomutase", ",", "could", "be", "attributed", "to", "changes", "in", "gene", "expression", "level", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0060764", "name": "C0060764#ent", "pos": [19, 20]}}
{"token": ["C0268354#ent", "<e1>", "a", "rare", ",", "C0796290#ent", "<e2>", "by", "a", "progeria-like", "appearance", "with", "distinctive", "facial", "features", "and", "cutis", "laxa"], "h": {"id": "C0268354", "name": "C0268354#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0796290", "name": "C0796290#ent", "pos": [5, 6]}}
{"token": ["C3827767#ent", "<e1>", "suppressed", "reactive", "oxygen", "species", "generation", "and", "p38", "mitogen-activated", "protein", "kinase", "activation", "restoring", "C0084340#ent", "<e2>", "signaling", "activity", "."], "h": {"id": "C3827767", "name": "C3827767#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [14, 15]}}
{"token": ["Tat-induced", "C1413290#ent", "<e1>", "been", "shown", "to", "phosphorylate", "Ser-5", "of", "RNA", "polymerase", "II", "C0035678#ent", "<e2>", "C-terminal", "domain", "CTD", ")", "."], "h": {"id": "C1413290", "name": "C1413290#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "show", "that", "C1413290#ent", "<e1>", ",", "the", "serine", "2", "C-terminal", "domain", "CTD", ")", "kinase", "for", "RNA", "polymerase", "II", "C0035678#ent", "<e2>", ",", "regulates", "H3K4", "methylation", "."], "h": {"id": "C1413290", "name": "C1413290#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [19, 20]}}
{"token": ["Expression", "of", "C0022959#ent", "<e1>", "from", "the", "C0039683#ent", "<e2>", "or", "by", "foreign", "ompA", "alleles", "are", "not", "expressed", "in", "E.", "coli", "K-12", "."], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039683", "name": "C0039683#ent", "pos": [6, 7]}}
{"token": ["The", "degradation", "at", "acidic", "pH", "was", "much", "reduced", "by", "C0718495#ent", "<e1>", "was", "strongly", "inhibited", "by", "the", "C3536890#ent", "<e2>", "leupeptin", "."], "h": {"id": "C0718495", "name": "C0718495#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536890", "name": "C3536890#ent", "pos": [16, 17]}}
{"token": ["Interestingly", ",", "the", "common", "C1276998#ent", "<e1>", "lithium", ",", "valproic", "acid", "VPA", ")", "and", "C0006949#ent", "<e2>", ",", "are", "teratogens", ",", "affecting", "a", "number", "of", "aspects", "of", "animal", "development"], "h": {"id": "C1276998", "name": "C1276998#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006949", "name": "C0006949#ent", "pos": [13, 14]}}
{"token": ["Gyokuheifusan", "(", "GHS", ")", "is", "a", "classical", "formulation", "of", "traditional", "Chinese", "medicine", "TCM", ")", "that", "is", "usually", "prescribed", "to", "prevent", "or", "treat", "C0035204#ent", "<e1>", "such", "as", "respiratory", "infection", "C0004096#ent", "<e2>"], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [22, 23]}, "relation": "nichd_parent_of", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [28, 29]}}
{"token": ["Radiation", "hybrid", "mapping", "the", "C1416481#ent", "<e1>", "AFM248yh1", ",", "which", "is", "in", "the", "critical", "region", "Bardet-Biedl", "syndrome", "type", "4", "C2936864#ent", "<e2>", ")", "on", "chromosome", "15"], "h": {"id": "C1416481", "name": "C1416481#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936864", "name": "C2936864#ent", "pos": [18, 19]}}
{"token": ["Mutating", "the", "potential", "palmitoylation", "site", "C213A", ")", "of", "C1419756#ent", "<e1>", "results", "in", "depalmitoylation", "and", "accumulation", "of", "C0252024#ent", "<e2>", "in", "the", "Golgi", "."], "h": {"id": "C1419756", "name": "C1419756#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0252024", "name": "C0252024#ent", "pos": [16, 17]}}
{"token": ["Taurohyodeoxycholic", "acid", "THDCA", ")", "and", "C0075857#ent", "<e1>", "TUDCA", ")", "both", "induced", "C0796517#ent", "<e2>", ",", "reductase", ",", "and", "MFOs", "."], "h": {"id": "C0075857", "name": "C0075857#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0796517", "name": "C0796517#ent", "pos": [11, 12]}}
{"token": ["This", "finding", "suggested", "that", "DNA", "fragmentation", "target", "cells", "is", "mediated", "not", "only", "by", "C1567160#ent", "<e1>", "but", "also", "by", "other", "molecules", ",", "including", "other", "C1333877#ent", "<e2>", "or", "Fas", "."], "h": {"id": "C1567160", "name": "C1567160#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1333877", "name": "C1333877#ent", "pos": [23, 24]}}
{"token": ["Temporal", "arteritis", "appear", "in", "patients", "under", "treatment", "for", "polymyalgia", "rheumatica", "and", "C0032533#ent", "<e1>", "rheumatica", "can", "be", "accompanied", "by", "C0029408#ent", "<e2>", "."], "h": {"id": "C0032533", "name": "C0032533#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [18, 19]}}
{"token": ["The", "muscle", "stiffness", "C0032533#ent", "<e1>", "PMR", ")", "must", "be", "distinguished", "from", "the", "C0029408#ent", "<e2>", "and", "other", "painful", "conditions", "common", "in", "the", "elderly", "."], "h": {"id": "C0032533", "name": "C0032533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [12, 13]}}
{"token": ["Peripherally", "induced", "paresthesias", "can", "be", "caused", "by", "C1510429#ent", "<e1>", "metabolic", "disturbances", "trauma", ",", "inflammation", ",", "C0175166#ent", "<e2>", "toxins", ",", "hereditary", "conditions", "malignancies", ",", "nutritional", "deficiencies", "miscellaneous", "conditions"], "h": {"id": "C1510429", "name": "C1510429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0175166", "name": "C0175166#ent", "pos": [15, 16]}}
{"token": ["The", "proteasome", "inhibitor", "C1176309#ent", "<e1>", ",", "and", "the", "histone", "deacetylase", "inhibitor", "depsipeptide", "(", "C2607887#ent", "<e2>", ")", ",", "up-regulate", "tumor", "death", "receptors"], "h": {"id": "C1176309", "name": "C1176309#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2607887", "name": "C2607887#ent", "pos": [13, 14]}}
{"token": ["C0030909#ent", "<e1>", "inhibited", "to", "a", "similar", "extent", "by", "ranitidine", "bismuth", "citrate", "C0106550#ent", "<e2>", "tripotassium", "dicitrato", "bismuthate", "concentrations", "equivalent", "to", "1", "mmol/L", "bismuth", ",", "but", "ranitidine", "(", "1", "mmol/L", ")", "was", "inactive", "."], "h": {"id": "C0030909", "name": "C0030909#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0106550", "name": "C0106550#ent", "pos": [11, 12]}}
{"token": ["The", "H(1)-binding", "scaffolds", "of", "cetirizine", ",", "C0055147#ent", "<e1>", ",", "and", "loratadine", "were", "linked", "to", "a", "lipophilic", "N-hydroxyurea", "the", "C2348848#ent", "<e2>", "inhibiting", "moiety", "of", "zileuton", "."], "h": {"id": "C0055147", "name": "C0055147#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2348848", "name": "C2348848#ent", "pos": [18, 19]}}
{"token": ["C0007761#ent", "<e1>", "a", "rare", "C0001126#ent", "<e2>", "by", "low-molecular", "weight", "proteinuria", "hypercalciuria", ",", "nephrocalcinosis", ",", "nephrolithiasis", ",", "rickets", "and", "eventual", "renal", "failure"], "h": {"id": "C0007761", "name": "C0007761#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001126", "name": "C0001126#ent", "pos": [4, 5]}}
{"token": ["Overexpression", "of", "a", "catalytically", "inactive", "C4084895#ent", "<e1>", "also", "inhibited", "the", "binding", "of", "ARF", "C1335589#ent", "<e2>", "to", "membranes", "and", "interfered", "with", "protein", "transport"], "h": {"id": "C4084895", "name": "C4084895#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335589", "name": "C1335589#ent", "pos": [13, 14]}}
{"token": ["We", "established", "the", "efficacy", "and", "safety", "of", "sublingual", "C0003596#ent", "<e1>", "compared", "with", "C0529793#ent", "<e2>", "comparable", "groups", "of", "patients", "with", "erectile", "dysfunction", "ED", ")", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0529793", "name": "C0529793#ent", "pos": [12, 13]}}
{"token": ["Effects", "of", "C0006230#ent", "<e1>", "bromocriptine", ")", "on", "plasma", "and", "pituitary", "PRL", "and", "C0027203#ent", "<e2>", "activities", "in", "lactating", "and", "postlactating", "rats", "have", "been", "investigated", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["The", "activity", "of", "the", "plasma", "membrane", "markers", "5'-nucleotidase", "and", "alkaline", "phosphatase", "increased", "by", "litter", "removal", ",", "and", "C0006230#ent", "<e1>", "further", "increased", "both", "C0027203#ent", "<e2>", "activities", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [22, 23]}}
{"token": ["We", "demonstrated", "that", "chromosomal", "DNA", "C0339959#ent", "<e1>", "present", "in", "synovial", "tissue", "at", "least", "some", "patients", "with", "C0035012#ent", "<e2>", "other", "arthritides", "."], "h": {"id": "C0339959", "name": "C0339959#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [16, 17]}}
{"token": ["Single", "administration", "of", "diphenhydramine", ",", "C0034282#ent", "<e1>", ",", "promethazine", "and", "chlorpheniramine", "caused", "dose-related", "C0007681#ent", "<e2>", "effects", "on", "the", "active", "avoidance", "."], "h": {"id": "C0034282", "name": "C0034282#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [13, 14]}}
{"token": ["It", "is", "concluded", "that", "C1418591#ent", "<e1>", "can", "either", "enhance", "or", "weaken", "C3540513#ent", "<e2>", "and", "that", "this", "complex", "effect", "on", "food", "selection", "can", "not", "be", "explained", "by", "PSD-induced", "reduction", "of", "fear", "."], "h": {"id": "C1418591", "name": "C1418591#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540513", "name": "C3540513#ent", "pos": [11, 12]}}
{"token": ["C0166059#ent", "<e1>", "MMP-7", ")", "expression", "was", "significantly", "higher", "in", "C1335822#ent", "<e2>", "compared", "with", "HCC", "."], "h": {"id": "C0166059", "name": "C0166059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335822", "name": "C1335822#ent", "pos": [9, 10]}}
{"token": ["Matrix", "metalloproteinase-7", "C0166059#ent", "<e1>", ")", "expression", "was", "significantly", "higher", "in", "C1335822#ent", "<e2>", "compared", "with", "HCC", "."], "h": {"id": "C0166059", "name": "C0166059#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335822", "name": "C1335822#ent", "pos": [10, 11]}}
{"token": ["Education", "programs", "needed", "to", "increase", "community", "awareness", "C1963718#ent", "<e1>", "and", "improve", "home", "management", "C0267446#ent", "<e2>"], "h": {"id": "C1963718", "name": "C1963718#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0267446", "name": "C0267446#ent", "pos": [13, 14]}}
{"token": ["Since", "the", "inception", "of", "the", "oral", "rehydration", "more", "than", "three", "decades", "ago", ",", "the", "widespread", "use", "of", "C1963718#ent", "<e1>", "solutions", "has", "revolutionized", "the", "management", "and", "outcomes", "of", "C0267446#ent", "<e2>", "children", "and", "adults", "."], "h": {"id": "C1963718", "name": "C1963718#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0267446", "name": "C0267446#ent", "pos": [27, 28]}}
{"token": ["Guidelines", "for", "efficacious", "use", "of", "C1963718#ent", "<e1>", "in", "the", "management", "of", "C0267446#ent", "<e2>", "short", "gut", "syndrome", "also", "provided", "."], "h": {"id": "C1963718", "name": "C1963718#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0267446", "name": "C0267446#ent", "pos": [11, 12]}}
{"token": ["The", "hypothesis", "was", "confirmed", "by", "a", "direct", "demonstration", "that", "Co(2", "+", ")", ",", "at", "C1335278#ent", "<e1>", "concentrations", ",", "powerfully", "inhibited", "C0015075#ent", "<e2>", "production", "in", "the", "cucumber", "hypocotyl"], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0015075", "name": "C0015075#ent", "pos": [20, 21]}}
{"token": ["c-Jun", "is", "an", "efficient", "activator", "of", "the", "c-jun", "and", "C0162745#ent", "<e1>", "which", "contain", "a", "single", "TRE", ";", "C0812313#ent", "<e2>", "is", "not", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812313", "name": "C0812313#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "we", "discovered", "that", "C1414199#ent", "<e1>", "Xdsh", ")", "forms", "a", "complex", "with", "Eph", "receptors", "C3830311#ent", "<e2>", "mediates", "the", "cell", "repulsion", "induced", "by", "Eph", "and", "ephrin", "."], "h": {"id": "C1414199", "name": "C1414199#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3830311", "name": "C3830311#ent", "pos": [17, 18]}}
{"token": ["The", "food", "intake", "pancreas", "weight", "C0960371#ent", "<e1>", "(", "EC", "3.4.21.4", "and", "alpha-chymotrypsin", "(", "EC", "3.4.21.1", "activities", "in", "the", "C0771711#ent", "<e2>", "were", "measured", "in", "rats", "during", "pregnancy", "and", "lactation", "and", "after", "the", "young", "were", "weaned", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [18, 19]}}
{"token": ["Surprisingly", ",", "co-expression", "of", "constitutive", "active", "ADF", "and", "C1413355#ent", "<e1>", "prevented", "efficient", "C0036117#ent", "<e2>", "entry", ",", "whereas", "expression", "of", "either", "one", "alone", "had", "no", "effect"], "h": {"id": "C1413355", "name": "C1413355#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [12, 13]}}
{"token": ["Classical", "multivesicular", "bodies", "observed", "fusing", "with", "lamellar", "bodies", "C2987364#ent", "<e1>", "and", "with", "the", "vesicular", "inclusions", "in", "C1442757#ent", "<e2>", "-/-", "mice", "that", "occasionally", "contained", "a", "few", "membrane", "lamellae"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1442757", "name": "C1442757#ent", "pos": [16, 17]}}
{"token": ["In", "fact", ",", "gingival", "tissues", "patients", "with", "C0001342#ent", "<e1>", "demonstrate", "greater", "levels", "of", "inducible", "nitric", "oxide", "C0669372#ent", "<e2>", ")", "expression", "than", "healthy", "tissue"], "h": {"id": "C0001342", "name": "C0001342#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}}
{"token": ["The", "C0001342#ent", "<e1>", "diseased", "tissue", "demonstrated", "a", "greater", "level", "of", "C0669372#ent", "<e2>", "expression", "than", "the", "healthy", "tissue"], "h": {"id": "C0001342", "name": "C0001342#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}}
{"token": ["Key", "protein", "differences", "adseverin", "and", "C1415323#ent", "<e1>", ",", "actin", "micro-filament", "splicing", "proteins", ",", "regulated", "by", "C0285558#ent", "<e2>", ",", "downstream", "of", "PI3-kinase", "activation", "."], "h": {"id": "C1415323", "name": "C1415323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [15, 16]}}
{"token": ["Phenytoin", "at", "a", "nontoxic", "dose", "mg/kg", "C0021171#ent", "<e1>", "obviously", "reduced", "the", "stage", "5", "C0036572#ent", "<e2>", "."], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "betaine", "administered", "C0021171#ent", "<e1>", "and", "intraventricularly", "to", "rats", "blocked", "pentylenetetrazol-induced", "seizures", ",", "but", "C0021171#ent", "<e1>", "betaine", "did", "not", "block", "C0036572#ent", "<e1>"], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [23, 24]}}
{"token": ["We", "found", "that", "pancreastatin", "receptor", "coupled", "with", "a", "G", "alpha(q/11", ")", "protein", "which", "activates", "C0250416#ent", "<e1>", "and", "phospholipase", "C-beta(3", ",", "in", "addition", "to", "C1370600#ent", "<e2>", "via", "both", "beta", "gamma", "alpha(q/11", ")", "."], "h": {"id": "C0250416", "name": "C0250416#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [23, 24]}}
{"token": ["In", "conclusion", ",", "C0008783#ent", "<e1>", "has", "no", "beneficial", "effects", "in", "C0030305#ent", "<e2>"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [10, 11]}}
{"token": ["The", "effectiveness", "of", "C0008783#ent", "<e1>", "in", "preventing", "complications", ",", "like", "C0030305#ent", "<e2>", "hemorrhagic", "gastritis", "after", "operations", "on", "Vater", "papilla", "ISP", ")", "is", "studied", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [10, 11]}}
{"token": ["At", "the", "C3538851#ent", "<e1>", ",", "angular", "motion", "unidirectional", ",", "as", "the", "hip", "flexed", "during", "C1539795#ent", "<e2>", "stance", "but", "extended", "during", "FWD", "stance", "."], "h": {"id": "C3538851", "name": "C3538851#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539795", "name": "C1539795#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "suggest", "that", "loss", "of", "regulation", "leading", "to", "C0907533#ent", "<e1>", "expression", "of", "C1425844#ent", "<e2>", "can", "contribute", "to", "oncogenesis", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425844", "name": "C1425844#ent", "pos": [13, 14]}}
{"token": ["We", "also", "studied", "the", "effects", "of", "new", "C0220821#ent", "<e1>", "which", "has", "antithrombotic", "properties", "on", "protein", "phosphorylation", "induced", "by", "C0009325#ent", "<e2>", "."], "h": {"id": "C0220821", "name": "C0220821#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [18, 19]}}
{"token": ["The", "small", "molecular", "mass", "C0752092#ent", "<e1>", "A", ",", "B", "and", "C", "are", "targets", "for", "C1567710#ent", "<e2>", "activity", "of", "the", "botulinum", "exoenzyme", "C3", "."], "h": {"id": "C0752092", "name": "C0752092#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1567710", "name": "C1567710#ent", "pos": [14, 15]}}
{"token": ["Hypoxia", "did", "not", "change", "the", "mRNA", "expression", "of", "C0907532#ent", "<e1>", "C0669365#ent", "<e2>", ")", ",", "the", "protein", "expression", "C0669365#ent", "<e2>", "or", "the", "eNOS", "regulatory", "protein", "caveolin-1", "as", "assessed", "by", "semiquantitative", "reverse", "transcription-polymerase", "chain", "reaction", "RT-PCR", ")", "or", "whole-mount", "immunostaining", "."], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [10, 11]}}
{"token": ["Six", "patients", "receiving", "C0016384#ent", "<e1>", "and", "three", "patients", "receiving", "C0985528#ent", "<e2>", "had", "objective", "evidence", "of", "improvement", "."], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0985528", "name": "C0985528#ent", "pos": [9, 10]}}
{"token": ["In", "this", "study", ",", "we", "have", "investigated", "in", "utero", "and", "in", "vitro", "of", "C0016384#ent", "<e1>", "(", "FLU", ")", "and", "C0985528#ent", "<e2>", "(", "DES", ")", "on", "fetal", "rat", "testicular", "steroidogenesis"], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0985528", "name": "C0985528#ent", "pos": [19, 20]}}
{"token": ["The", "C0085174#ent", "<e1>", "component", "of", "C0717703#ent", "<e2>", "may", "also", "help", "to", "restore", "homeostasis", "in", "tissues", "other", "than", "the", "gut", "."], "h": {"id": "C0085174", "name": "C0085174#ent", "pos": [1, 2]}, "relation": "part_of", "t": {"id": "C0717703", "name": "C0717703#ent", "pos": [5, 6]}}
{"token": ["The", "levels", "of", "c-Ha-ras", "and", "C0079973#ent", "<e1>", "mRNAs", "were", "unaffected", "by", "C0032143#ent", "<e2>", "treatment", "in", "all", "cell", "lines"], "h": {"id": "C0079973", "name": "C0079973#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [11, 12]}}
{"token": ["C1412689#ent", "<e1>", "an", "autosomal", "recessive", "copper", "C0267971#ent", "<e2>", "from", "an", "inability", "of", "the", "liver", "to", "excrete", "copper", "."], "h": {"id": "C1412689", "name": "C1412689#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0267971", "name": "C0267971#ent", "pos": [6, 7]}}
{"token": ["In", "vitro", "stimulation", "of", "AMs", "with", "Th1-related", "cytokines", "(", "C1334105#ent", "<e1>", "and", "IFN-gamma", ")", "upregulated", "the", "expression", "of", "CD80", "and", "C2698599#ent", "<e2>"], "h": {"id": "C1334105", "name": "C1334105#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2698599", "name": "C2698599#ent", "pos": [20, 21]}}
{"token": ["The", "two", "members", "of", "the", "MHC", "class", "I", "chain-related", "MIC", ")", "C1335597#ent", "<e1>", "MICA", "and", "C1417163#ent", "<e2>", ",", "have", "been", "shown", "by", "several", "investigators", "to", "be", "polymorphic", "."], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417163", "name": "C1417163#ent", "pos": [15, 16]}}
{"token": ["We", "have", "previously", "examined", "pilocytic", "astrocytomas", "C0002085#ent", "<e1>", "losses", "on", "chromosomes", "10", "19q", "and", "for", "amplification", "of", "the", "C0242982#ent", "<e2>", "but", "did", "not", "detect", "genomic", "alterations", "these", "loci", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242982", "name": "C0242982#ent", "pos": [18, 19]}}
{"token": ["Some", "of", "the", "lipids", "that", "are", "substrates", "for", "C1413336#ent", "<e1>", "can", "also", "be", "hydrolysed", "by", "C1418708#ent", "<e2>"], "h": {"id": "C1413336", "name": "C1413336#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418708", "name": "C1418708#ent", "pos": [15, 16]}}
{"token": ["The", "coordinated", "regulation", "of", "C1413336#ent", "<e1>", "another", "lipid", "digestive", "enzyme", "the", "C1418708#ent", "<e2>", "suggested", "an", "important", "role", "for", "these", "proteins", "in", "dietary", "lipid", "absorption", "the", "gastrointestinal", "tract"], "h": {"id": "C1413336", "name": "C1413336#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418708", "name": "C1418708#ent", "pos": [11, 12]}}
{"token": ["There", "is", "some", "evidence", "that", "the", "resultant", "C0752235#ent", "<e1>", "be", "a", "more", "severe", "variant", "of", "C4083008#ent", "<e2>", "with", "predominant", "axonal", "degeneration"], "h": {"id": "C0752235", "name": "C0752235#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4083008", "name": "C4083008#ent", "pos": [15, 16]}}
{"token": ["We", "sought", "to", "characterize", "the", "C1868501#ent", "<e1>", "at", "supra-MICs", "of", "C1413800#ent", "<e2>", "among", "clinical", "Candida", "sp.", "isolates", "grown", "as", "biofilms", "in", "96-well", "polystyrene", "microtiter", "plates"], "h": {"id": "C1868501", "name": "C1868501#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413800", "name": "C1413800#ent", "pos": [10, 11]}}
{"token": ["Two", "incomplete", "ORFs", "flanking", "the", "C0020208#ent", "<e1>", "utilization", "genes", "similarities", "to", "C1417679#ent", "<e2>", "involved", "in", "transposition", "."], "h": {"id": "C0020208", "name": "C0020208#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["It", "serves", "as", "a", "cofactor", "of", "C0036734#ent", "<e1>", "inactivation", "of", "complement", "C3b", "C1412999#ent", "<e2>", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [12, 13]}}
{"token": ["IF", "is", "a", "highly", "specific", "C0036734#ent", "<e1>", "cleaves", "the", "alpha-chains", "of", "C3b", "and", "C1412999#ent", "<e2>", "and", "thus", "downregulates", "activation", "of", "both", "the", "classical", "and", "the", "alternative", "complement", "pathways"], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [13, 14]}}
{"token": ["C4b-binding", "protein", "C4BP", ")", "inhibits", "all", "pathways", "of", "complement", "activation", "acting", "as", "a", "cofactor", "to", "the", "C0036734#ent", "<e1>", "FI", ")", "in", "the", "degradation", "of", "activated", "complement", "factors", "C1412999#ent", "<e2>", "and", "C3b", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [27, 28]}}
{"token": ["Calcium", "antagonists", "(", "verapamil", ",", "C0795749#ent", "<e1>", "and", "trifluoroperazine", ")", "and", "C0022022#ent", "<e2>", "A23187", "and", "Br-X537A", ")", "failed", "to", "modify", "insulin", "release", "or", "45Ca", "uptake", "by", "each", "of", "the", "two", "tumours", "tested", "."], "h": {"id": "C0795749", "name": "C0795749#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [11, 12]}}
{"token": ["Eighty", "adult", "patients", "with", "classical", "or", "definite", "C0003873#ent", "<e1>", "given", "200", "bolus", "injections", "of", "intramuscular", "C0600901#ent", "<e2>", "MPA", ")", "over", "four", "years", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0600901", "name": "C0600901#ent", "pos": [15, 16]}}
{"token": ["Because", "C0009079#ent", "<e1>", "is", "known", "to", "block", "muscarinic", "as", "well", "as", "5-HT2", "receptors", "C1161352#ent", "<e2>", "was", "studied", "in", "DOM-trained", "rats", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [13, 14]}}
{"token": ["The", "binding", "of", "C0009079#ent", "<e1>", "to", "muscarinic", "sites", "inhibited", "in", "the", "presence", "of", "C1161352#ent", "<e2>", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [13, 14]}}
{"token": ["Therefore", ",", "in", "an", "attempt", "to", "identify", "maspin-interacting", "proteins", "and", "thereby", "gain", "insight", "into", "the", "functional", "pathways", "C0919445#ent", "<e1>", ",", "we", "employed", "a", "maspin-baited", "yeast", "two-hybrid", "system", "subsequently", "identified", "Interferon", "Regulatory", "Factor", "6", "C1416474#ent", "<e2>", ")", "as", "a", "maspin-binding", "protein"], "h": {"id": "C0919445", "name": "C0919445#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416474", "name": "C1416474#ent", "pos": [33, 34]}}
{"token": ["In", "C0268790#ent", "<e1>", "as", "atherosclerosis", "and", "diabetes", ",", "C0907532#ent", "<e2>", "NO", ")", "bioactivity", "is", "reduced", "and", "oxidative", "stress", "increased", ",", "resulting", "in", "endothelial", "dysfunction"], "h": {"id": "C0268790", "name": "C0268790#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0907532", "name": "C0907532#ent", "pos": [8, 9]}}
{"token": ["Similar", "distribution", "patterns", "of", "CAT", "and", "C1419788#ent", "<e1>", "immunoreactivities", "were", "found", "in", "the", "medial", "septal", "nucleus", "C0026269#ent", "<e2>", ")", "and", "the", "nucleus", "of", "the", "diagonal", "band", "of", "Broca", "DBB", ")", "."], "h": {"id": "C1419788", "name": "C1419788#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [16, 17]}}
{"token": ["A", "34-year-old", "patient", "prophylactically", "received", "tuberculostatic", "treatment", "with", "C0546863#ent", "<e1>", "and", "isoniazide", "after", "having", "had", "an", "allogenic", "renal", "transplant", "immunosuppression", "with", "C0360556#ent", "<e2>", "and", "cyclosporine", "."], "h": {"id": "C0546863", "name": "C0546863#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0360556", "name": "C0360556#ent", "pos": [21, 22]}}
{"token": ["A1-antichymotrypsin", "(", "C1412050#ent", "<e1>", ")", ",", "part", "of", "an", "extended", "C1413514#ent", "<e2>", "was", "discussed", "to", "contribute", "to", "PR3-ANCA", "associated", "vasculitis", "formation", "."], "h": {"id": "C1412050", "name": "C1412050#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413514", "name": "C1413514#ent", "pos": [10, 11]}}
{"token": ["In", "summary", ",", "an", "oncogenic", "9bp", "duplication", "of", "C0813143#ent", "<e1>", "causes", "Ret", "dimer", "formation", "and", "ligand", "independent", "activation", "of", "the", "C0033681#ent", "<e2>"], "h": {"id": "C0813143", "name": "C0813143#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [20, 21]}}
{"token": ["A", "C0017363#ent", "<e1>", "at", "least", "24", "homologs", "of", "a", "C0036734#ent", "<e2>", "been", "identified", "in", "S.", "scabiei", "."], "h": {"id": "C0017363", "name": "C0017363#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [9, 10]}}
{"token": ["Concurrent", "treatment", "with", "TNF", "alpha", "the", "antioxidant", ",", "C0147003#ent", "<e1>", ",", "or", "the", "iron-chelating", "agent", "C3253705#ent", "<e2>", ",", "also", "reduces", "NOS", "activity", "."], "h": {"id": "C0147003", "name": "C0147003#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3253705", "name": "C3253705#ent", "pos": [15, 16]}}
{"token": ["Sweet's", "syndrome", "an", "acute", "febrile", "neutrophilic", "dermatosis", "by", "attacks", "of", "C0030193#ent", "<e1>", ",", "plaque-forming", "inflammatory", "papules", "accompanied", "by", "fever", ",", "C0003862#ent", "<e2>", ",", "peripheral", "leukocytosis", "a", "diffuse", "dermal", "neutrophilic", "infiltrate", "and", "prompt", "resolution", "of", "symptoms", "and", "lesions", "with", "glucocorticoid", "therapy"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [20, 21]}}
{"token": ["The", "modest", ",", "but", "clinically", "relevant", ",", "efficacy", "of", "C2698196#ent", "<e1>", "treatment", "in", "C0003873#ent", "<e2>", "adds", "to", "the", "evidence", "for", "important", "anti-inflammatory", "properties", "statins", "."], "h": {"id": "C2698196", "name": "C2698196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}}
{"token": ["A", "high", "degree", "of", "suspicion", "is", "required", "when", "treating", "a", "patient", "who", "presents", "with", "C0013404#ent", "<e1>", "and", "new", "radiological", "infiltrates", "receiving", "a", "C0082645#ent", "<e2>", "IIb/IIIa", "inhibitor", "."], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [22, 23]}}
{"token": ["Attention", "is", "then", "directed", "to", "the", "action", "of", "C0006280#ent", "<e1>", "the", "resolution", "of", "a", "proven", "state", "of", "C0006266#ent", "<e2>", "."], "h": {"id": "C0006280", "name": "C0006280#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [17, 18]}}
{"token": ["The", "Raw", "and", "CDyn", "changes", "were", "prevented", "and", "reversed", "with", "the", "C0006280#ent", "<e1>", "aminophylline", "indicating", "that", "reversible", "C0006266#ent", "<e2>", "are", "induced", "in", "guinea", "pigs", "following", "a", "period", "of", "hyperventilation", "."], "h": {"id": "C0006280", "name": "C0006280#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [17, 18]}}
{"token": ["The", "therapeutic", "efficacy", "of", "atropine", "and", "salbutamol", "sprays", "or", "in", "association", "was", "experimented", "in", "patients", "with", "atopic", "bronchial", "asthma", "part", "of", "an", "investigation", "of", "the", "C0006280#ent", "<e1>", "the", "pathogenesis", "of", "C0006266#ent", "<e2>", "."], "h": {"id": "C0006280", "name": "C0006280#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [30, 31]}}
{"token": ["The", "peptides", "inhibiting", "C0917721#ent", "<e1>", "isolated", "from", "the", "hydrolysate", "of", "oyster", "(", "Crassostrea", "gigas", "C0086376#ent", "<e2>", "prepared", "with", "thermolysin", "."], "h": {"id": "C0917721", "name": "C0917721#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}}
{"token": ["The", "synovial", "fluid", "SF", ")", "cells", "of", "rheumatoid", "arthritis", "C0002893#ent", "<e1>", ")", "patients", "express", "a", "specific", "C1332712#ent", "<e2>", "variant", "designated", "CD44vRA", "."], "h": {"id": "C0002893", "name": "C0002893#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332712", "name": "C1332712#ent", "pos": [16, 17]}}
{"token": ["About", "50", "%", "inhibition", "was", "achieved", "by", "preincubating", "the", "enzyme", "with", "2.5", "microM", "of", "C2984132#ent", "<e1>", ",", "50", "microM", "of", "C1825573#ent", "<e2>", "or", "GM3", ",", "and", "80", "microM", "of", "GM1", "."], "h": {"id": "C2984132", "name": "C2984132#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1825573", "name": "C1825573#ent", "pos": [20, 21]}}
{"token": ["A", "coexistent", "dual", "deficiency", "C1415597#ent", "<e1>", "PBG-D", ";", "EC", "4.3.1.8", ")", "and", "C0042085#ent", "<e2>", "EC", "4.1.1.37", ")", "in", "erythrocytes", "was", "recognized", "in", "five", "individuals", ",", "four", "males", "and", "one", "female", "."], "h": {"id": "C1415597", "name": "C1415597#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042085", "name": "C0042085#ent", "pos": [12, 13]}}
{"token": ["For", "example", ",", "trigeminal", "neuropathy", "heralds", "the", "onset", "of", "C0036421#ent", "<e1>", "mixed", "connective", "tissue", "disease", "and", "sensory", "neuronopathy", "be", "the", "initial", "presenting", "feature", "of", "C0151449#ent", "<e2>"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [24, 25]}}
{"token": ["Six", "had", "the", "CREST", "variant", "of", "C0036421#ent", "<e1>", "also", "had", "features", "of", "C0151449#ent", "<e2>", "SS", ")", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [12, 13]}}
{"token": ["Two", "nonidentical", "intracellular", "sequences", "of", "about", "240", "amino", "acids", "are", "C1334043#ent", "<e1>", "with", "a", "C0085536#ent", "<e2>", "sequence", "have", "been", "identified", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [14, 15]}}
{"token": ["Elevation", "of", "intracellular", "cAMP", "by", "C0917964#ent", "<e1>", "markedly", "increased", "protein", "levels", "MITF", ",", "tyrosinase", "and", "C1413933#ent", "<e2>", ",", "however", "there", "was", "no", "concomitant", "increase", "in", "tyrosinase", "or", "C1413933#ent", "<e2>", "mRNA", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413933", "name": "C1413933#ent", "pos": [15, 16]}}
{"token": ["Consistent", "with", "evidence", ",", "we", "demonstrate", "that", "RNPS1", ",", "Y14", ",", "C1424457#ent", "<e1>", ",", "REF/Aly", ",", "TAP", ",", "Upf3X", "and", "C1425133#ent", "<e2>", "are", "detected", "in", "the", "nuclear", "fraction", "CBP80-bound", "but", "not", "eIF4E-bound", "mRNA", "."], "h": {"id": "C1424457", "name": "C1424457#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1425133", "name": "C1425133#ent", "pos": [20, 21]}}
{"token": ["Following", "GZ", "treatment", "C0020456#ent", "<e1>", "failed", "to", "stimulate", "C0017932#ent", "<e2>", "activity", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [8, 9]}}
{"token": ["We", "also", "determined", "whether", "increasing", "the", "rate", "of", "glucose", "disposal", "C0020456#ent", "<e1>", "at", "a", "fixed", "insulin", "concentration", "activates", "C0017932#ent", "<e2>"], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [18, 19]}}
{"token": ["C0086647#ent", "<e1>", "was", "separated", "into", "two", "C0027117#ent", "<e2>", "in", "the", "same", "manner", "as", "in", "the", "case", "of", "immunoglobulin", "to", "produce", "Fr", "."], "h": {"id": "C0086647", "name": "C0086647#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027117", "name": "C0027117#ent", "pos": [6, 7]}}
{"token": ["In", "an", "extended", "family", ",", "we", "were", "able", "to", "add", "C0010278#ent", "<e1>", "and", "developmental", "delay", "the", "clinical", "spectrum", "associated", "with", "C1416917#ent", "<e2>", "mutations", "."], "h": {"id": "C0010278", "name": "C0010278#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416917", "name": "C1416917#ent", "pos": [20, 21]}}
{"token": ["Lamina-associated", "polypeptide", "LAP", ")", "2", "of", "the", "inner", "nuclear", "membrane", "now", "LAP2beta", ")", "and", "C0906560#ent", "<e1>", "are", "related", "C0086376#ent", "<e2>", "produced", "by", "alternative", "splicing", ",", "and", "contain", "a", "common", "187", "amino", "acid", "N-terminal", "domain"], "h": {"id": "C0906560", "name": "C0906560#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [18, 19]}}
{"token": ["The", "C0022895#ent", "<e1>", "was", "affected", "by", "catabolite", "repression", "and", "induced", "by", "C1161331#ent", "<e2>", "or", "fructose", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [11, 12]}}
{"token": ["Recovery", "from", "adaptation", "was", "measured", "in", "acoustically-traumatized", "ears", "of", "cats", "for", "pure-tone", "adapters", "1", "-", "60", "s", "in", "C0720099#ent", "<e1>", "at", "levels", "of", "60", "-", "100", "dB", "C1420014#ent", "<e2>", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420014", "name": "C1420014#ent", "pos": [27, 28]}}
{"token": ["Periodic", "pulses", "intense", "ultrasound", "energy", "70", "kHz", "with", "5-ms", "C0720099#ent", "<e1>", "at", "3", "MPa", "C1420014#ent", "<e2>", "applied", "to", "the", "exposed", "pig", "myocardium", "at", "physiologic", "rhythms", "observed", "to", "produce", "cardiac", "pacing"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420014", "name": "C1420014#ent", "pos": [14, 15]}}
{"token": ["Recurrent", ",", "C0149516#ent", "<e1>", "late", "sequelae", "occur", "unless", "neonatal", "C0008149#ent", "<e2>", "which", "is", "often", "multifocal", ",", "is", "effectively", "treated", "."], "h": {"id": "C0149516", "name": "C0149516#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008149", "name": "C0008149#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "continued", "antalgic", "postures", "in", "response", "to", "at", "the", "dominant", "side", "in", "FMS", "patients", "might", "lead", "to", "asymmetries", "of", "C1419960#ent", "<e1>", "level", ",", "TEMP", "and", "C1704894#ent", "<e2>", "."], "h": {"id": "C1419960", "name": "C1419960#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1704894", "name": "C1704894#ent", "pos": [28, 29]}}
{"token": ["These", "results", "show", "that", "distinct", "functionally", "active", "sites", "for", "C1417807#ent", "<e1>", "exist", "on", "both", "C1412137#ent", "<e2>", "endothelial", "cells"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [14, 15]}}
{"token": ["Atrial", "natriuretic", "peptide", "C1417807#ent", "<e1>", ")", "is", "a", "diuretic", "and", "C1412137#ent", "<e2>", "relaxant", "which", "plays", "a", "pivotal", "role", "in", "cardiovascular", "regulation"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [10, 11]}}
{"token": ["The", "C0079414#ent", "<e1>", "a", "protein", "belonging", "to", "the", "immunoglobulin", "superfamily", "similarity", "to", "the", "C0021699#ent", "<e2>", "is", "a", "putative", "tumor-suppressor", "gene"], "h": {"id": "C0079414", "name": "C0079414#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [13, 14]}}
{"token": ["The", "C0079414#ent", "<e1>", "a", "protein", "belonging", "to", "the", "immunoglobulin", "superfamily", "similarity", "to", "the", "C0021699#ent", "<e2>", "and", "it", "is", "a", "putative", "tumor-suppressor", "gene"], "h": {"id": "C0079414", "name": "C0079414#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [13, 14]}}
{"token": ["Administration", "of", "clonidine", "to", "the", "ganglion", ",", "however", ",", "did", "depress", "C1422341#ent", "<e1>", "evoked", "by", "the", "ganglionic", "stimulant", "1,1-dimethyl-4-phenylpiperazinium", "iodide", "C0012847#ent", "<e2>", ",", "10", "micrograms", "i.a", ".", ")", "."], "h": {"id": "C1422341", "name": "C1422341#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012847", "name": "C0012847#ent", "pos": [20, 21]}}
{"token": ["These", "electrophysiological", "studies", "that", "native", "38", "pS", "K+", "channels", "of", "the", "C1416596#ent", "<e1>", "family", "in", "cultured", "C3540479#ent", "<e2>", "neurones", "consist", "of", "both", "homomeric", "TASK-3", "and", "heteromeric", "TASK-1/TASK-3", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540479", "name": "C3540479#ent", "pos": [16, 17]}}
{"token": ["The", "plant", "flavonol", "quercetin", "the", "triazine", "herbicides", "C0030969#ent", "<e1>", ",", "cyanazine", ",", "and", "C0878411#ent", "<e2>", "were", "examined", "individually", "and", "in", "combination", "for", "the", "induction", "of", "genotoxic", "effects"], "h": {"id": "C0030969", "name": "C0030969#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0878411", "name": "C0878411#ent", "pos": [13, 14]}}
{"token": ["Haemorrhages", "in", "the", "upper", "GI", "tract", "lead", "to", "severe", "C0042749#ent", "<e1>", "and", ",", "in", "patients", "with", "C0162557#ent", "<e2>", "to", "hyperammonaemia", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [16, 17]}}
{"token": ["The", "putrescine", "conjugate", "was", "purified", "to", "homogeneity", "by", "column", "chromatography", "Biogels", "P10", "and", "C1704715#ent", "<e1>", "followed", "by", "ion-exchange", "chromatography", "C0057214#ent", "<e2>"], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0057214", "name": "C0057214#ent", "pos": [19, 20]}}
{"token": ["These", "included", "mercuric", "chloride", "C0037506#ent", "<e1>", "formaldehyde", ",", "dimethyl", "sulfoxide", "benzoyl", "peroxide", "and", "C0022020#ent", "<e2>", ",", "all", "of", "which", "have", "been", "proven", "to", "be", "positive", "in", "the", "Draize", "test", "or", "in", "cutaneous", "toxicity", "studies"], "h": {"id": "C0037506", "name": "C0037506#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022020", "name": "C0022020#ent", "pos": [13, 14]}}
{"token": ["C0034678#ent", "<e1>", "was", "studied", "under", "basal", "conditions", ",", "standing", ",", "after", "C0036193#ent", "<e2>", "(", "a", "specific", "angiotensin", "II", "antagonist", "and", "after", "acebutolol", "(", "a", "cardioselective", "beta-blocker", "an", "inhibitor", "of", "renin", "secretion", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036193", "name": "C0036193#ent", "pos": [11, 12]}}
{"token": ["The", "analgesic", "effect", "C0952503#ent", "<e1>", "the", "spasmolytic", "component", "A29", "(", "C3495393#ent", "<e2>", ")", "and", "morphine", "hydrochloride", "compared", "double-blindly", "in", "patients", "with", "suspect", "acute", "myocardial", "infarction"], "h": {"id": "C0952503", "name": "C0952503#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3495393", "name": "C3495393#ent", "pos": [10, 11]}}
{"token": ["MurI", "binds", "to", "GyrA", "subunit", "the", "enzyme", "leading", "to", "a", "decrease", "in", "C0812382#ent", "<e1>", "of", "the", "C0282109#ent", "<e2>", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282109", "name": "C0282109#ent", "pos": [16, 17]}}
{"token": ["C0021246#ent", "<e1>", "significantly", "reduced", "the", "C1705347#ent", "<e2>", "responses", "at", "the", "ankle", "joint", ",", "but", "aprotinin", "reduced", "it", "at", "the", "other", "two", "regions", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705347", "name": "C1705347#ent", "pos": [5, 6]}}
{"token": ["The", "association", "of", "preexisting", "CAD", "and", "C3273681#ent", "<e1>", "and", "the", "effect", "of", "C0082608#ent", "<e2>", "on", "enzyme", "activity", "investigated", "in", "a", "placebo-controlled", "trial", "patients", "with", "T2DM", "."], "h": {"id": "C3273681", "name": "C3273681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0082608", "name": "C0082608#ent", "pos": [12, 13]}}
{"token": ["Fluvastatin", "not", "only", "decreases", "atherogenic", "dLDL", "but", "also", "C3273681#ent", "<e1>", "activity", ",", "emphasizing", "the", "significance", "of", "C0082608#ent", "<e2>", "treatment", "in", "T2DM", "."], "h": {"id": "C3273681", "name": "C3273681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0082608", "name": "C0082608#ent", "pos": [16, 17]}}
{"token": ["We", "found", "that", "panneural", "expression", "CAPS", "C2712370#ent", "<e1>", "the", "pathfinding", "of", "muscle", "12", "C1706550#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706550", "name": "C1706550#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "inhibition", "of", "converting", "C0014442#ent", "<e1>", "in", "humans", "with", "established", "C0017667#ent", "<e2>", "glomerular", "permeability", "proteins", "by", "enhancing", "barrier", "size", "selectivity", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017667", "name": "C0017667#ent", "pos": [12, 13]}}
{"token": ["These", "results", "are", "a", "novel", "demonstration", "of", "control", "of", "Fos", "expression", "by", "dopaminergic", "drugs", "the", "C1705443#ent", "<e1>", "and", "by", "C2987634#ent", "<e2>", "the", "GP", "."], "h": {"id": "C1705443", "name": "C1705443#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [19, 20]}}
{"token": ["In", "humans", ",", "susceptibility", "to", "several", "immunopathologic", "diseases", "maps", "to", "a", "conserved", "block", "encompassing", "the", "polymorphic", "BAT1", "NFKBIL1", "(", "C1417711#ent", "<e1>", ")", "and", "TNF", "C1417679#ent", "<e2>", "in", "the", "central", "MHC"], "h": {"id": "C1417711", "name": "C1417711#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["Point", "mutations", "deletions", "in", "the", "androgen", "receptor", "gene", "androgen", "insensitivity", "syndrome", "however", "subjects", "with", "C1839259#ent", "<e1>", "normal", "virilization", "although", "progressive", "gynaecomastia", ",", "C0156312#ent", "<e2>", "infertility", "may", "occur", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0156312", "name": "C0156312#ent", "pos": [22, 23]}}
{"token": ["In", "this", "group", "of", "six", "patients", ",", "there", "was", "a", "significant", "correlation", "between", "the", "AR", "C1839259#ent", "<e1>", "and", "the", "severity", "of", "C0156312#ent", "<e2>", "gynecomastia", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0156312", "name": "C0156312#ent", "pos": [21, 22]}}
{"token": ["Mitogenic", "stimulation", "by", "TGF-beta", "1", "C1522073#ent", "<e1>", "enhanced", "by", "forskolin", ",", "which", "activates", "C1382029#ent", "<e2>", "at", "concentrations", "up", "to", "0.5", "microM", "forskolin", "."], "h": {"id": "C1522073", "name": "C1522073#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [13, 14]}}
{"token": ["However", ",", "wus", "was", "epistatic", "to", "C1415274#ent", "<e1>", "in", "the", "center", "of", "the", "flower", ",", "and", "C2681417#ent", "<e2>", "transcriptional", "repression", "delayed", "in", "ult1", "floral", "meristems"], "h": {"id": "C1415274", "name": "C1415274#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2681417", "name": "C2681417#ent", "pos": [16, 17]}}
{"token": ["Hypotensive", "effect", "after", "intake", "of", "C0016860#ent", "<e1>", "was", "observed", "in", "patients", "with", "IIB", "stage", "C0020538#ent", "<e2>"], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [14, 15]}}
{"token": ["In", "these", "dosages", "the", "reported", "frequency", "of", "attacks", "of", "C0027404#ent", "<e1>", "was", "roughly", "halved", "with", "each", "treatment", ",", "C0011810#ent", "<e2>", "30", "mg", "daily", "being", "only", "slightly", "more", "potent", "than", "10", "mg", "."], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0011810", "name": "C0011810#ent", "pos": [18, 19]}}
{"token": ["Less", "than", "10", "%", "of", "all", "subjects", "with", "the", "C0027404#ent", "<e1>", "a", "daytime", "sleep", "in", "the", "normal", "range", "on", "C0011810#ent", "<e2>", "and", "no", "subject", "on", "clomipramine", "reported", "complete", "control", "of", "cataplexy", "."], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0011810", "name": "C0011810#ent", "pos": [19, 20]}}
{"token": ["Twenty", "patients", "with", "the", "C0027404#ent", "<e1>", "treated", "separately", "with", "C0011810#ent", "<e2>", "10", "and", "30", "mg", ",", "Dexedrine", "Spansules", "mg", ",", "mazindol", "4", ",", "and", "fencamfamin", "hydrochloride", "mg", "daily", "."], "h": {"id": "C0027404", "name": "C0027404#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0011810", "name": "C0011810#ent", "pos": [9, 10]}}
{"token": ["With", "the", "increased", "use", "of", "C0034283#ent", "<e1>", "and", "dapsone", "in", "the", "treatment", "of", "C0494261#ent", "<e2>", "HIV", ")", "infection", ",", "this", "form", "of", "drug", "allergy", "become", "more", "common", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0494261", "name": "C0494261#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "C0398625#ent", "<e1>", "been", "hypothesized", "to", "cause", "a", "C0398623#ent", "<e2>", "could", "induce", "thrombosis", "in", "small", "vessels", "with", "resulting", "skin", "ischemia", "necrosis", ",", "and", "gangrene", "."], "h": {"id": "C0398625", "name": "C0398625#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [9, 10]}}
{"token": ["Several", "previous", "studies", "reported", "that", "hereditary", "protein", "S", "deficiency", "as", "common", "as", "C0398625#ent", "<e1>", "that", "approximately", "5", "%", "of", "C0398623#ent", "<e2>", "caused", "by", "protein", "S", "deficiency"], "h": {"id": "C0398625", "name": "C0398625#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [19, 20]}}
{"token": ["Since", "hospital-", "or", "C0206171#ent", "<e1>", "E.", "Coli", "strongly", "resistant", "to", "aminopenicillins", "and", "C0041044#ent", "<e2>", ",", "these", "antibacterials", "must", "not", "be", "used", "as", "first-line", "treatment", "pyelonephritis", "."], "h": {"id": "C0206171", "name": "C0206171#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "H.", "influenzae", "isolates", "from", "C0206171#ent", "<e1>", "less", "susceptible", "(", "78.6", "-", "81.7", "%", ")", "to", "C0041044#ent", "<e2>", ",", "but", "very", "susceptible", "to", "fluoroquinolones", "(", "99.9", "-", "100.0", "%", ")", "."], "h": {"id": "C0206171", "name": "C0206171#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [18, 19]}}
{"token": ["TrCP2", "silencing", "is", "more", "effective", "on", "GHR", "degradation", "and", "endocytosis", "than", "C3272739#ent", "<e1>", ",", "although", "overexpression", "of", "either", "C0597298#ent", "<e2>", "restores", "TrCP", "function", "in", "silenced", "cells", "."], "h": {"id": "C3272739", "name": "C3272739#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [18, 19]}}
{"token": ["There", "was", "a", "significantly", "increased", "concanavalin", "A", "induced", "release", "of", "C1522575#ent", "<e1>", "in", "LN", "and", "C0017661#ent", "<e2>", "patients", "with", "nephrotic", "syndrome", "compared", "with", "normal", "controls"], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [15, 16]}}
{"token": ["Her", "pre/postoperative", "serum", "level", "of", "C1522575#ent", "<e1>", "1,880/52.3", "pg/ml", ",", "suggesting", "its", "elevation", "was", "associated", "with", "C0017661#ent", "<e2>", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [16, 17]}}
{"token": ["We", "have", "investigated", "the", "molecular", "lesions", "C0268562#ent", "<e1>", "typical", "or", "C0751748#ent", "<e2>", "NKH", ")", "in", "two", "unrelated", "pedigrees", "."], "h": {"id": "C0268562", "name": "C0268562#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751748", "name": "C0751748#ent", "pos": [10, 11]}}
{"token": ["Expression", "of", "the", "C0017337#ent", "<e1>", "for", "a", "rat", "intestinal", "C1334347#ent", "<e2>", "MLP", ")", "was", "studied", "by", "Northern-blot", "analyses", "of", "RNA", "prepared", "from", "a", "panel", "of", "rat", "tissues", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334347", "name": "C1334347#ent", "pos": [9, 10]}}
{"token": ["C2020625#ent", "<e1>", "conjugated", "with", "C1384510#ent", "<e2>", "produced", "a", "strong", "systemic", "and", "local", "anti-CPSIII", "response", "after", "i.n", "."], "h": {"id": "C2020625", "name": "C2020625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1384510", "name": "C1384510#ent", "pos": [4, 5]}}
{"token": ["These", "improved", "initially", "with", "more", "frequent", "infusions", "of", "hdIVIg", "but", "C0304604#ent", "<e1>", "required", "to", "treat", "worsening", "C0026848#ent", "<e2>", "."], "h": {"id": "C0304604", "name": "C0304604#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [16, 17]}}
{"token": ["Their", "neutralization", "by", "the", "CD4-binding", "site-directed", "agents", "CD4-IgG2", "and", "NAb", "C3538796#ent", "<e1>", "was", "also", "unaffected", "by", "2G12", "binding", "to", "uncleaved", "C0017343#ent", "<e2>", "."], "h": {"id": "C3538796", "name": "C3538796#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017343", "name": "C0017343#ent", "pos": [20, 21]}}
{"token": ["This", "may", "suggest", "that", "hormone", "modulation", "of", "the", "C1332675#ent", "<e1>", "requires", "synergistic", "estrogen", "and", "C3536949#ent", "<e2>", "actions", "."], "h": {"id": "C1332675", "name": "C1332675#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [14, 15]}}
{"token": ["Through", "expression", "studies", "Xenopus", "oocytes", "mammalian", "cells", "we", "found", "that", "the", "m1", "muscarinic", "acetylcholine", "receptor", "mAChR", ")", "potently", "suppresses", "a", "cloned", "delayed", "rectifier", "potassium", "channel", "termed", "C1384553#ent", "<e1>", ",", "through", "a", "pathway", "involving", "phospholipase", "C", "activation", "direct", "tyrosine", "phosphorylation", "the", "C1333577#ent", "<e2>"], "h": {"id": "C1384553", "name": "C1384553#ent", "pos": [26, 27]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333577", "name": "C1333577#ent", "pos": [40, 41]}}
{"token": ["Loss", "of", "epithelial", "proteins", "claudin", "1", "claudin", "7", "mislocalization", "of", "C0909826#ent", "<e1>", "E-cadherin", ",", "and", "the", "expression", "of", "mesenchymal", "proteins", "C1421451#ent", "<e2>", "and", "alpha-smooth", "muscle", "actin", "were", "observed", "."], "h": {"id": "C0909826", "name": "C0909826#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421451", "name": "C1421451#ent", "pos": [20, 21]}}
{"token": ["There", "are", "two", "principal", "C3541394#ent", "<e1>", "involved", "in", "the", "formation", "of", "circulating", "1,25(OH)2D3", "from", "C3537249#ent", "<e2>", "the", "vitamin", "D", "25-hydroxylase", "25-OHase", ")", "and", "the", "1alpha-hydroxylase", "(", "1alpha-OHase", ")", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537249", "name": "C3537249#ent", "pos": [14, 15]}}
{"token": ["Hence", ",", "during", "exercise", ",", "only", "C3814032#ent", "<e1>", "neurons", "that", "are", "firing", "should", "increase", "C3814032#ent", "<e1>", "production/release", "when", "brain", "C1705940#ent", "<e1>", "rises", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [19, 20]}}
{"token": ["The", "results", "suggest", "that", "the", "elevations", "in", "brain", "C3814032#ent", "<e1>", "and", "5HIAA", "levels", "produced", "by", "caffeine", "do", "not", "reflect", "enhanced", "C3814032#ent", "<e1>", "synthesis", ",", "despite", "significant", "elevations", "in", "brain", "C1705940#ent", "<e1>", "level", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [29, 30]}}
{"token": ["It", "is", "not", "known", "which", "C3814032#ent", "<e1>", "neurons", "fire", "during", "exercise", ";", "the", "C3814032#ent", "<e1>", "neurons", "that", "respond", "to", "exercise-induced", "increases", "in", "brain", "C1705940#ent", "<e1>", "are", "therefore", "not", "known", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [23, 24]}}
{"token": ["We", "found", "that", "the", "ConA", "and", "WGA", "plus", "C0256103#ent", "<e1>", "treated", "cells", "inhibited", "approximately", "50", "%", "by", "10", "microM", "C0042523#ent", "<e2>", ",", "nicardipine", "or", "TMB-8", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [19, 20]}}
{"token": ["Intervention", "strategies", "are", "a", "multimodal", "psychological", "programme", "for", "the", "intervention", "in", "early", "C3494359#ent", "<e1>", "a", "combination", "of", "psychotherapy", "with", "atypical", "C0040615#ent", "<e2>", "the", "late", "prodromal", "stages"], "h": {"id": "C3494359", "name": "C3494359#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [20, 21]}}
{"token": ["Monitoring", "to", "detect", "C3494359#ent", "<e1>", "symptoms", "is", "especially", "important", "in", "targeted", "treatment", ",", "otherwise", ",", "C0040615#ent", "<e2>", "can", "not", "be", "initiated", "in", "time", "."], "h": {"id": "C3494359", "name": "C3494359#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [15, 16]}}
{"token": ["Abnormalities", "in", "the", "genes", "for", "C0020179#ent", "<e1>", "neurofibromatosis", "types", "1", "2", ",", "one", "form", "of", "familial", "amyotrophic", "lateral", "sclerosis", "fragile", "X", "syndrome", "myotonic", "dystrophy", "C1839259#ent", "<e2>", "Menkes", "disease", ",", "and", "several", "forms", "of", "retinitis", "pigmentosa", "been", "elucidated", "."], "h": {"id": "C0020179", "name": "C0020179#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [24, 25]}}
{"token": ["T2", "filaments", "were", "removed", "by", "chondroitinase", "(Ch)-ABC", "Ch-ABC", "plus", "Streptomyces", "(S)-hyaluronidase", "and", "C0033417#ent", "<e1>", ",", "but", "resistant", "to", "nitrous", "acid", "heparitinase", ",", "C0062507#ent", "<e2>", ",", "neuraminidase", "and", "S-hyaluronidase", "."], "h": {"id": "C0033417", "name": "C0033417#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0062507", "name": "C0062507#ent", "pos": [22, 23]}}
{"token": ["It", "is", "concluded", "that", "acute", "beta", "blockade", "C0116569#ent", "<e1>", "can", "be", "achieved", "in", "patients", "with", "C1647218#ent", "<e2>", "and", "cardiac", "disorders", "little", "risk", "of", "bronchospasm", "."], "h": {"id": "C0116569", "name": "C0116569#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [15, 16]}}
{"token": ["Primary", "muscle", "disorders", "lead", "to", "C0011168#ent", "<e1>", "(", "for", "example", ",", "with", "polymyositis", "or", "C0270952#ent", "<e2>", "or", "defects", "of", "large", "bowel", "motility", "for", "example", ",", "with", "Duchenne's", "muscular", "dystrophy", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0270952", "name": "C0270952#ent", "pos": [14, 15]}}
{"token": ["Human", "ZFHX4", "has", "recently", "been", "shown", "to", "be", "a", "candidate", "C0017337#ent", "<e1>", "for", "congenital", "bilateral", "isolated", "C0033377#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033377", "name": "C0033377#ent", "pos": [16, 17]}}
{"token": ["Human", "ZFH-4", "is", "therefore", "a", "candidate", "C0017337#ent", "<e1>", "for", "congenital", "bilateral", "isolated", "C0033377#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033377", "name": "C0033377#ent", "pos": [12, 13]}}
{"token": ["To", "map", "the", "C0017337#ent", "<e1>", "responsible", "for", "Blepharophimosis", "Epicanthus", "Inversus", "C0033377#ent", "<e2>", "syndrome(BPES", ")", "type", "I", "in", "a", "Chinese", "family"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033377", "name": "C0033377#ent", "pos": [10, 11]}}
{"token": ["Extrarenal", "changes", ",", "such", "as", "dietary", "phosphate", ",", "systemic", "hypertension", "C0020473#ent", "<e1>", ",", "acidosis", "and", "C1840402#ent", "<e2>", "occur", "in", "animals", "with", "renal", "disease", "may", "be", "contributors", "to", "progression", "of", "renal", "disease"], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [15, 16]}}
{"token": ["C0025942#ent", "<e1>", ",", "ketoconazole", ",", "and", "C0040379#ent", "<e2>", "inhibited", "the", "lipid", "synthesis"], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040379", "name": "C0040379#ent", "pos": [6, 7]}}
{"token": ["In", "vitro", "sensitivity", "tests", "indicated", "econazole", "to", "be", "the", "best", "drug", "against", "all", "30", "isolates", "of", "Trichophyton", "species", "by", "C0025942#ent", "<e1>", ",", "clotrimazole", "and", "C0040379#ent", "<e2>", "."], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0040379", "name": "C0040379#ent", "pos": [24, 25]}}
{"token": ["Methylthioadenosine", "phosphorylase", "C1417407#ent", "<e1>", ")", "is", "known", "as", "a", "ubiquitously", "expressed", "house", "keeping", "C0017337#ent", "<e2>", "important", "in", "biochemical", "salvage", "."], "h": {"id": "C1417407", "name": "C1417407#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["The", "predicted", "amino", "acid", "aa", ")", "sequence", "of", "C1538768#ent", "<e1>", "reveals", "a", "single", "zinc", "finger", "domain", "of", "fungal", "C1427248#ent", "<e2>", "factors", ",", "and", "the", "zinc", "finger", "60", "%", "aa", "identity", "to", "that", "of", "human", "GATA-1", "."], "h": {"id": "C1538768", "name": "C1538768#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1427248", "name": "C1427248#ent", "pos": [18, 19]}}
{"token": ["Molecules", "with", "an", "effect", "on", "C0567085#ent", "<e1>", "receptivity", "for", "blastocyst", "implantation", "integrins", ",", "leukaemia", "inhibitory", "factor", "LIF", ")", ",", "C1522428#ent", "<e2>", "(", "IL-1", ")", "and", "colony", "stimulating", "factor-1", "CSF-1", ")", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [19, 20]}}
{"token": ["The", "C0108342#ent", "<e1>", "value", "of", "the", "C3541397#ent", "<e2>", "over", "the", "period", "increased", "by", "12-fold", "of", "its", "initial", "value", "of", "27.5", "mEq/kg", ",", "suggesting", "light", "susceptibility", "photo-oxidative", "degradation", "."], "h": {"id": "C0108342", "name": "C0108342#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3541397", "name": "C3541397#ent", "pos": [6, 7]}}
{"token": ["Moreover", ",", "most", "members", "of", "these", "C0206522#ent", "<e1>", "seem", "to", "be", "under", "catabolite", "repression", "mediated", "by", "C1879974#ent", "<e2>", "."], "h": {"id": "C0206522", "name": "C0206522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1879974", "name": "C1879974#ent", "pos": [16, 17]}}
{"token": ["Erbium--169", "was", "compared", "with", "C0077004#ent", "<e1>", "the", "topical", "treatment", "32", "patients", "suffering", "from", "C0003873#ent", "<e2>"], "h": {"id": "C0077004", "name": "C0077004#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "C0033805#ent", "<e1>", "may", "require", "treatment", "similar", "to", "that", "for", "C0010674#ent", "<e2>", "prevent", "long-term", "respiratory", "complications"], "h": {"id": "C0033805", "name": "C0033805#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [11, 12]}}
{"token": ["Glibenclamide", "(", "glyburide", ")", ",", "gliclazide", ",", "C0017642#ent", "<e1>", "and", "glimepiride", "are", "the", "C0038766#ent", "<e2>", "current", "clinical", "use", "type", "2", "diabetes", "mellitus"], "h": {"id": "C0017642", "name": "C0017642#ent", "pos": [7, 8]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [13, 14]}}
{"token": ["The", "structure", "and", "effect", "of", "C0017642#ent", "<e1>", ",", "the", "second", "generation", "derivates", "of", "C0038766#ent", "<e2>", "were", "described", "."], "h": {"id": "C0017642", "name": "C0017642#ent", "pos": [5, 6]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [13, 14]}}
{"token": ["This", "improvement", "in", "the", "insulin", "effect", "be", "an", "acute", "one", "among", "the", "so", "called", "\"", "extra-pancreatic", "\"", "actions", "which", "have", "been", "demonstrated", "for", "C0017642#ent", "<e1>", "and", "other", "C0038766#ent", "<e2>", "."], "h": {"id": "C0017642", "name": "C0017642#ent", "pos": [23, 24]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [27, 28]}}
{"token": ["The", "piperidine", "nitroxides", "C3272771#ent", "<e1>", ",", "TEMPO", ",", "and", "butylTEMPOL", "reacted", "similarly", "with", "C0077656#ent", "<e2>", "in", "organic", "solvents", "in", "mitochondrial", "membranes", "rates", "varied", "in", "the", "order", ":", "MitoTEMPOL", ">"], "h": {"id": "C3272771", "name": "C3272771#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0077656", "name": "C0077656#ent", "pos": [13, 14]}}
{"token": ["As", "TTPA", "and", "C1707995#ent", "<e1>", "have", "been", "implicated", "in", "C0220701#ent", "<e2>", "RP", ")", ",", "altered", "SEC14L1", "expression", "may", "contribute", "to", "RP", "in", "previously", "unlinked", "families", "."], "h": {"id": "C1707995", "name": "C1707995#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [9, 10]}}
{"token": ["We", "could", "find", "no", "evidence", "that", "mutations", "of", "the", "C1707995#ent", "<e1>", "associated", "with", "common", "forms", "of", "C0220701#ent", "<e2>", "Usher's", "syndrome", "type", "I."], "h": {"id": "C1707995", "name": "C1707995#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [16, 17]}}
{"token": ["Wild-type", "and", "catalytically", "inactive", "PI3K_68D", "transgenes", "have", "opposite", "effects", "on", "the", "number", "of", "sensory", "bristles", "and", "on", "C3538717#ent", "<e1>", "venation", "phenotypes", "induced", "by", "modified", "C1367721#ent", "<e2>", "EGF", ")", "receptor", "signaling"], "h": {"id": "C3538717", "name": "C3538717#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [24, 25]}}
{"token": ["Swim-induced", "analgesia", "in", "intact", "HA", "animals", "was", "significantly", "reduced", "by", "naloxone", "and", "C0011777#ent", "<e1>", "while", "in", "C1420423#ent", "<e2>", "mice", "these", "two", "compounds", "were", "ineffective", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [16, 17]}}
{"token": ["The", "SH2", "domain", "the", "C0282625#ent", "<e1>", "recognizes", "a", "sequence", "of", "C0039659#ent", "<e2>", "featuring", "a", "phosphotyrosine", "and", "a", "lipophilic", "aminoacid", "the", "+", "1", "and", "+", "3", "positions", "."], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039659", "name": "C0039659#ent", "pos": [10, 11]}}
{"token": ["The", "C0626649#ent", "<e1>", "C0079429#ent", "<e2>", "is", "a", "new", "C0079429#ent", "<e2>", "discovered", "by", "the", "molecular", "analysis", "a", "t(4;16", ")", "translocation", ",", "characteristic", "of", "a", "human", "T", "cell", "lymphoma"], "h": {"id": "C0626649", "name": "C0626649#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}}
{"token": ["The", "Portland", "alpha1-antitrypsin", "variant", "(", "alpha1-PDX", ")", "inhibits", "gp160", "cleavage", "into", "gp120", "and", "gp41", "by", "different", "C3849253#ent", "<e1>", "PCs", ")", "including", "furin", ",", "C1418391#ent", "<e2>", "and", "PC7", "."], "h": {"id": "C3849253", "name": "C3849253#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418391", "name": "C1418391#ent", "pos": [23, 24]}}
{"token": ["In", "contrast", ",", "after", "C3542409#ent", "<e1>", "selective", "blockade", "by", "rauwolscine", ",", "C0031469#ent", "<e2>", "but", "not", "B-HT", "933", "caused", "a", "marked", "decrease", "in", "blood", "flow"], "h": {"id": "C3542409", "name": "C3542409#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [11, 12]}}
{"token": ["C0919509#ent", "<e1>", "bound", "well", "to", "C0919506#ent", "<e2>", "but", "poorly", "to", "FGF8", "and", "FGF9", "."], "h": {"id": "C0919509", "name": "C0919509#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919506", "name": "C0919506#ent", "pos": [5, 6]}}
{"token": ["Both", "C1826469#ent", "<e1>", "and", "fu-1", "cells", "express", "C0001497#ent", "<e2>", "(", "ATP", ":", "AMP", "phosphotransferase", "EC", "2.7.4.3)", "activities", "in", "single", "cells"], "h": {"id": "C1826469", "name": "C1826469#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001497", "name": "C0001497#ent", "pos": [7, 8]}}
{"token": ["Both", "C1826469#ent", "<e1>", "and", "fu-1", "cells", "express", "myokinase", "(", "ATP", ":", "C0001497#ent", "<e2>", "EC", "2.7.4.3)", "activities", "in", "single", "cells"], "h": {"id": "C1826469", "name": "C1826469#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001497", "name": "C0001497#ent", "pos": [11, 12]}}
{"token": ["Dysphoria", ",", "akathisia", ",", "depressed", "mood", "suicidal", "ideation", "insomnia", ",", "racing", "thoughts", ",", "and", "C1414509#ent", "<e1>", "affect", "were", "seen", "following", "the", "administration", "of", "C0025853#ent", "<e2>", "."], "h": {"id": "C1414509", "name": "C1414509#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [23, 24]}}
{"token": ["The", "present", "study", "evaluated", "whether", "alcohol", "feeding", "C1412234#ent", "<e1>", "expression", "and", "whether", "C1412234#ent", "<e1>", "is", "a", "lipid", "droplet", "marker", "C0400966#ent", "<e1>", "rats", "."], "h": {"id": "C1412234", "name": "C1412234#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0400966", "name": "C0400966#ent", "pos": [19, 20]}}
{"token": ["Molar", "percentage", "C0981805#ent", "<e1>", "and", "valeric", "acids", "lower", "and", "for", "butyric", "acid", "higher", "for", "sheep", "C0342895#ent", "<e2>", "whey", "."], "h": {"id": "C0981805", "name": "C0981805#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [15, 16]}}
{"token": ["The", "C0003993#ent", "<e1>", "an", "important", "element", "in", "the", "therapy", "of", "acute", "lymphoblastic", "leukaemia", "C1704799#ent", "<e2>", ")", "."], "h": {"id": "C0003993", "name": "C0003993#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704799", "name": "C1704799#ent", "pos": [13, 14]}}
{"token": ["The", "C0003993#ent", "<e1>", "an", "important", "component", "of", "the", "treatment", "protocols", "Acute", "Lymphoblastic", "Leukemia", "C1704799#ent", "<e2>", ")", "."], "h": {"id": "C0003993", "name": "C0003993#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704799", "name": "C1704799#ent", "pos": [13, 14]}}
{"token": ["Mutation", "analysis", "the", "PTPN11", "gene", "carried", "out", "in", "C3489545#ent", "<e1>", "in", "150", "patients", "with", "C0041409#ent", "<e2>"], "h": {"id": "C3489545", "name": "C3489545#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041409", "name": "C0041409#ent", "pos": [14, 15]}}
{"token": ["By", "contrast", ",", "three", "drugs", "with", "primary", "sexual", "arousal", "effects", "(", "C0724441#ent", "<e1>", ",", "imiloxan", ",", "and", "idazoxan", ")", ",", "are", "potent", "C0035064#ent", "<e2>", "at", "alpha", "2-adrenergic", "receptors", "by", "[3H]yohimbine", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [22, 23]}}
{"token": ["One", "hopes", "that", "interest", "can", "be", "eventually", "generated", "for", "the", "proper", "assessment", "of", "C0724441#ent", "<e1>", "in", "a", "different", "formulation", "or", "in", "combination", "with", "other", "C0035064#ent", "<e2>", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [24, 25]}}
{"token": ["We", "evaluated", "the", "individual", "and", "combined", "effects", "of", "an", "inhaled", "beta-adrenergic", "agent", "C0025573#ent", "<e1>", ")", "and", "an", "inhaled", "anticholinergic", "agent", "C0004259#ent", "<e2>", ")", "on", "the", "pulmonary", "function", "infants", "with", "bronchopulmonary", "dysplasia"], "h": {"id": "C0025573", "name": "C0025573#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [20, 21]}}
{"token": ["moreover", "there", "is", "a", "wide", "range", "of", "C0029896#ent", "<e1>", "due", "to", "C1959635#ent", "<e2>", "exanthema/rash", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1959635", "name": "C1959635#ent", "pos": [11, 12]}}
{"token": ["This", "paper", "describes", "various", "C0029896#ent", "<e1>", "by", "ergot", ",", "afflatoxin", ",", "ochratoxin", "A", "C0047640#ent", "<e2>", "trichothecene", ",", "zearalenone", ",", "and", "fumonisin", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0047640", "name": "C0047640#ent", "pos": [13, 14]}}
{"token": ["C0020102#ent", "<e1>", "is", "associated", "with", "variety", "of", "C0012634#ent", "<e2>", "adult", "T-cell", "leukemia", "ATL", ")", "and", "non-neoplastic", "inflammatory", "diseases"], "h": {"id": "C0020102", "name": "C0020102#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [7, 8]}}
{"token": ["The", "3", "cell", "lines", "C1705027#ent", "<e1>", "amplification", "also", "expressed", "C4042483#ent", "<e2>", "high", "levels", "."], "h": {"id": "C1705027", "name": "C1705027#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4042483", "name": "C4042483#ent", "pos": [9, 10]}}
{"token": ["The", "microcytosis", "and", "C0002886#ent", "<e1>", "the", "study", "population", "be", "attributed", "to", "the", "C0472762#ent", "<e2>", "is", "highly", "prevalent", "in", "Oman", "."], "h": {"id": "C0002886", "name": "C0002886#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0472762", "name": "C0472762#ent", "pos": [12, 13]}}
{"token": ["Both", "compounds", "were", "found", "to", "be", "inactive", "in", "rats", "against", "carbachol", "stimulated", "gastric", "secretion", "C0009443#ent", "<e1>", "restraint", "induced", "C0149745#ent", "<e2>", "."], "h": {"id": "C0009443", "name": "C0009443#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0149745", "name": "C0149745#ent", "pos": [18, 19]}}
{"token": ["To", "analyze", "the", "hepatic", "and", "intestinal", "microcirculation", "an", "animal", "model", "liver", "cirrhosis", "C0021390#ent", "<e1>", "IBD", ")", "and", "to", "characterize", "the", "anti-inflammatory", "action", "antithrombin", "III", "C1412610#ent", "<e2>", ")", "on", "leukocyte", "kinetics", "and", "liver", "damage"], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412610", "name": "C1412610#ent", "pos": [24, 25]}}
{"token": ["To", "analyze", "the", "hepatic", "and", "intestinal", "microcirculation", "an", "animal", "model", "liver", "cirrhosis", "inflammatory", "bowel", "disease", "C0021390#ent", "<e1>", ")", "and", "to", "characterize", "the", "anti-inflammatory", "action", "antithrombin", "III", "C1412610#ent", "<e2>", ")", "on", "leukocyte", "kinetics", "and", "liver", "damage"], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412610", "name": "C1412610#ent", "pos": [26, 27]}}
{"token": ["In", "addition", "to", "the", "synthesis", "of", "angiotensin", "II", "C4084825#ent", "<e1>", "is", "involved", "in", "transforming", "growth", "factor-beta", "and", "cleaves", "Type", "I", "procollagen", "produce", "C0009325#ent", "<e2>", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [22, 23]}}
{"token": ["The", "relative", "potency", "against", "exercise-tachicardia", "was", "propranolol", "greater", "than", "C0004147#ent", "<e1>", "greater", "than", "C0063460#ent", "<e2>", "."], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0063460", "name": "C0063460#ent", "pos": [13, 14]}}
{"token": ["The", "focal", "thickening", "cyst", "wall", "Pneumocystis", ",", "as", "demonstrated", "by", "C1705457#ent", "<e1>", "and", "manifested", "as", "a", "\"", "C0030552#ent", "<e2>", "\"", "shaped", "structure", "silver", "stain", "serves", "as", "a", "diagnostic", "marker", "Pneumocystis", "."], "h": {"id": "C1705457", "name": "C1705457#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [17, 18]}}
{"token": ["These", "C1413043#ent", "<e1>", "+", "pulses", "trigger", "C1332447#ent", "<e2>", "that", "include", "the", "activation", "of", "Ca(2+)-regulated", "protein", "kinases", ",", "which", "are", "required", "for", "stimulation", "of", "the", "oxidative", "burst"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [6, 7]}}
{"token": ["More", "than", "20", "C0991617#ent", "<e1>", "are", "substrates", "for", "debrisoquin", "hydroxylase", "about", "15", "for", "C0259190#ent", "<e2>", ",", "and", "3", "-", "5", "for", "mephenytoin", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0259190", "name": "C0259190#ent", "pos": [13, 14]}}
{"token": ["The", "activity", "of", "C0031607#ent", "<e1>", "elevated", "by", "C0360097#ent", "<e2>", "and", "decreased", "by", "hypoxic", "treatment", "."], "h": {"id": "C0031607", "name": "C0031607#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0360097", "name": "C0360097#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "novel", "agents", "targeting", "the", "pre-existing", "NSCLC", "vasculature", "(", "i.e.", "C1122629#ent", "<e1>", "VDAs", ")", "or", "C1268567#ent", "<e2>", "emerged", "as", "unique", "drug", "classes", "promising", "results", "in", "several", "preclinical", "and", "clinical", "studies"], "h": {"id": "C1122629", "name": "C1122629#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [16, 17]}}
{"token": ["Some", "etiological", "aspects", "commented", "upon", "as", "well", "as", "differential", "diagnosis", "which", "must", "be", "done", "with", "a", "certain", "number", "of", "C0012634#ent", "<e1>", "that", "produce", "C0021843#ent", "<e2>", "the", "newborn", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0021843", "name": "C0021843#ent", "pos": [23, 24]}}
{"token": ["This", "highly", "conserved", "region", "of", "the", "aromatic", "amino", "acid", "hydroxylases", "11", "out", "of", "17", "C3539946#ent", "<e1>", "identical", "in", "phenylalanine", "hydroxylase", "tyrosine", "hydroxylase", "C1420870#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [22, 23]}}
{"token": ["When", "the", "hypertensive", "coarcted", "monkey", "preestablished", "C0010054#ent", "<e1>", "treated", "with", "low", "cholesterol", "diet", "a", "combination", "of", "antihypertensive", "drugs", "C0020261#ent", "<e2>", ",", "hydralazine", ",", "and", "reserpine", ")", ",", "the", "progression", "of", "the", "disease", "was", "arrested", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [18, 19]}}
{"token": ["Vagotomy", "at", "the", "midcervical", "portion", "increased", "the", "incidence", "of", "C0034063#ent", "<e1>", "a", "rate", "of", "100", "%", ",", "whereas", "pretreatment", "with", "C1161352#ent", "<e2>", "did", "not", "affect", "the", "incidence", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [20, 21]}}
{"token": ["Results", "show", "that", "both", "the", "leaf", "and", "stem-bark", "extracts", "significantly", "increased", "the", "activities", "of", "serum", "and", "C0312398#ent", "<e1>", "liver", "acid", "phosphatase", "liver", "and", "C0017755#ent", "<e2>", "fructose-1,6-diphosphatase", "and", "glycogen", "in", "the", "treated", "rats", "."], "h": {"id": "C0312398", "name": "C0312398#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [23, 24]}}
{"token": ["Muscimol", ",", "a", "GABAA", "receptor", "agonist", "caused", "a", "significant", "suppression", "of", "the", "high", "potassium", "100", "mM)-evoked", "release", "of", "GABA", ",", "and", "this", "suppressive", "effect", "C0026818#ent", "<e1>", "was", "antagonized", "invariably", "by", "bicuculline", ",", "a", "C0242975#ent", "<e2>"], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0242975", "name": "C0242975#ent", "pos": [33, 34]}}
{"token": ["These", "experiments", "examined", "the", "effects", "of", "systemic", "administration", "the", "GABAergic", "agonist", "C0026818#ent", "<e1>", "and", "the", "C0242975#ent", "<e2>", "bicuculline", "on", "retention", "in", "mice", "with", "bilateral", "lesions", "of", "the", "amygdala", ",", "dorsal", "hippocampus", "caudate", "nucleus"], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242975", "name": "C0242975#ent", "pos": [15, 16]}}
{"token": ["[Ca2+]i", "was", "increased", "by", "GABA", "and", "the", "GABAA", "receptor", "agonist", "C0026818#ent", "<e1>", ",", "and", "these", "responses", "were", "inhibited", "by", "the", "C0242975#ent", "<e2>", "bicuculline", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242975", "name": "C0242975#ent", "pos": [20, 21]}}
{"token": ["Lys-539", ",", "a", "probable", "reaction", "site", "C4281938#ent", "<e1>", ",", "lies", "within", "the", "same", "segment", "of", "C1420193#ent", "<e2>", "that", "is", "labeled", "by", "NAP-taurine", "and", "thus", "may", "be", "part", "of", "the", "modifier", "site"], "h": {"id": "C4281938", "name": "C4281938#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [15, 16]}}
{"token": ["Whim", "syndrome", "an", "association", "of", "warts", ",", "hypogammaglobulinemia", ",", "recurrent", "bacterial", "infections", "the", "retention", "of", "mature", "C0064833#ent", "<e1>", "the", "bone", "marrow", "an", "C0920627#ent", "<e2>"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0920627", "name": "C0920627#ent", "pos": [22, 23]}}
{"token": ["Flavopiridol", "is", "a", "broad-spectrum", "inhibitor", "of", "C0243045#ent", "<e1>", "of", "global", "transcription", "the", "inhibition", "of", "positive", "transcription", "elongation", "factor", "b", "C0663446#ent", "<e2>", ")", "."], "h": {"id": "C0243045", "name": "C0243045#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0663446", "name": "C0663446#ent", "pos": [19, 20]}}
{"token": ["Consistent", "results", "were", "observed", "with", "Tbx20", "loss", "of", "function", "where", "the", "expression", "of", "C1705781#ent", "<e1>", "genes", "increased", "and", "C0623362#ent", "<e2>", "decreased", "."], "h": {"id": "C1705781", "name": "C1705781#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [18, 19]}}
{"token": ["The", "sequence", "analysis", "C3540790#ent", "<e1>", "that", "might", "modify", "bacterial", "sulfatases", "should", "be", "useful", "in", "the", "task", "of", "identifying", "the", "human", "sulfatase-modifying", "homologs", "--", "C3540790#ent", "<e1>", "that", "are", "defective", "in", "the", "rare", "inherited", "disease", "C0268263#ent", "<e1>"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268263", "name": "C0268263#ent", "pos": [33, 34]}}
{"token": ["C0004057#ent", "<e1>", "causes", "gastroduodenal", "erosions", "and/or", "C0149745#ent", "<e2>", "in", "man", "when", "taken", "for", "prolonged", "periods", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0149745", "name": "C0149745#ent", "pos": [6, 7]}}
{"token": ["Taken", "together", ",", "our", "results", "highlight", "the", "mechanistic", "similarities", "and", "differences", "between", "C0694888#ent", "<e1>", "and", "the", "conventional", "C0031686#ent", "<e2>", "reveal", "how", "a", "disease-associated", "mutation", "inactivates", "C0694888#ent", "<e1>", "."], "h": {"id": "C0694888", "name": "C0694888#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [17, 18]}}
{"token": ["Heifers", "treated", "with", "GnRH", "C2987634#ent", "<e1>", "from", "early", "in", "the", "oestrous", "cycle", "a", "larger", "C0010093#ent", "<e2>", "secrete", "more", "progesterone", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010093", "name": "C0010093#ent", "pos": [14, 15]}}
{"token": ["The", "overall", "results", "of", "clinical", "trials", "C2987634#ent", "<e1>", "of", "LH-RH", "for", "induction", "of", "inadequate", "C0010093#ent", "<e2>", "luteolysis", "or", "early", "abortion", "women", "are", "not", "impressive", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010093", "name": "C0010093#ent", "pos": [14, 15]}}
{"token": ["Thermal", "transitions", "were", "measured", "by", "differential", "scanning", "calorimetry", "rabbit", "cardiac", "sarcolemma", "3-(N-morpholino)propanesulfonic", "acid", "buffer", "at", "pH", "7.5", ",", "in", "glycerol-buffer", "and", "C0012403#ent", "<e1>", "buffer", "mixtures", ",", "after", "heat", "denaturation", "and", "after", "enzymatic", "degradation", "the", "C0086376#ent", "<e2>", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [34, 35]}}
{"token": ["We", "observed", "somatic", "and", "germline", "mosaicism", "well", "as", "parent-to-child", "transmission", "of", "non-mosaic", "C1427038#ent", "<e1>", "mutations", "as", "causes", "of", "C2936502#ent", "<e2>"], "h": {"id": "C1427038", "name": "C1427038#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2936502", "name": "C2936502#ent", "pos": [18, 19]}}
{"token": ["The", "methylation", "of", "CaaX", "proteins", "and", "the", "CXC", "C0752065#ent", "<e1>", "carried", "out", "by", "a", "single", "membrane", "methyltransferase", "the", "endoplasmic", "reticulum", "C1415845#ent", "<e2>", "(", "for", "isoprenylcysteine", "carboxyl", "methyltransferase", "."], "h": {"id": "C0752065", "name": "C0752065#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415845", "name": "C1415845#ent", "pos": [20, 21]}}
{"token": ["However", ",", "C2986870#ent", "<e1>", "associated", "with", "bronchiolitis", "obliterans", "pneumonia", "of", "C0032310#ent", "<e2>", "present", "in", "three", "(", "8", "%", ")", "and", "CIB", "in", "15", "(", "42", "%", ")", "of", "control", "TBB", "associated", "with", "acute", "rejection", "infection", "."], "h": {"id": "C2986870", "name": "C2986870#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032310", "name": "C0032310#ent", "pos": [10, 11]}}
{"token": ["While", "acute", "rejection", "been", "shown", "to", "be", "associated", "with", "increased", "risk", "of", "development", "of", "C2986870#ent", "<e1>", ",", "cytomegalovirus", "(", "CMV", ")", "C0032310#ent", "<e2>", "is", "more", "controversial", "as", "a", "risk", "factor", "C2986870#ent", "<e1>", "."], "h": {"id": "C2986870", "name": "C2986870#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032310", "name": "C0032310#ent", "pos": [21, 22]}}
{"token": ["Pretreatment", "with", "a", "C0595726#ent", "<e1>", "but", "not", "a", "platelet-activating", "factor-receptor", "antagonist", "a", "C0085387#ent", "<e2>", "abolished", "the", "increased", "susceptibility", "of", "sensitized", "rats", "to", "gastric", "damage", "induced", "by", "antigen", "and", "topical", "ethanol"], "h": {"id": "C0595726", "name": "C0595726#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [12, 13]}}
{"token": ["The", "enhanced", "histamine-", "and", "5-HT-induced", "bronchoconstrictions", "were", "antagonized", "by", "the", "C0595726#ent", "<e1>", "and", "by", "the", "C0085387#ent", "<e2>", "BW755c", "."], "h": {"id": "C0595726", "name": "C0595726#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [15, 16]}}
{"token": ["Serum", "C1868193#ent", "<e1>", "levels", "were", "significantly", "higher", "in", "C1561643#ent", "<e2>", "hemodialysis", "(", "1796.0", "+", "/-", "1492.9", "ng/mL", ")", "than", "in", "other", "diseases", "such", "as", "peptic", "ulcer", "liver", "cirrhosis", "gallstone", ",", "and", "diabetes", "mellitus"], "h": {"id": "C1868193", "name": "C1868193#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [8, 9]}}
{"token": ["Enzyme", "activity", "assayed", "in", "the", "presence", "of", "0", ",", "0.01", ",", "0.1", ",", "and", "1.00", "microM", "thiopental", ",", "C0022614#ent", "<e1>", ",", "etomidate", ",", "midazolam", ",", "and", "C0031507#ent", "<e2>", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [26, 27]}}
{"token": ["We", "conclude", "that", "there", "exists", "receptor", "autophosphorylation", "not", "previously", "identified", "which", "allow", "for", "signaling", "via", "C1418640#ent", "<e1>", ",", "as", "well", "as", "C1565427#ent", "<e2>", "and", "paxillin", "."], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [21, 22]}}
{"token": ["Mutations", "in", "C1311470#ent", "<e1>", "are", "involved", "in", "some", "cases", "of", "autosomal", "recessive", "juvenile", "parkinsonism", "C1418270#ent", "<e2>", ")", ",", "but", "it", "is", "not", "known", "how", "they", "result", "in", "nigral", "cell", "death"], "h": {"id": "C1311470", "name": "C1311470#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [14, 15]}}
{"token": ["C1423100#ent", "<e1>", "shares", "this", "domain", "with", "C0023764#ent", "<e2>", "human", "adipose", "triglyceride", "lipase"], "h": {"id": "C1423100", "name": "C1423100#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023764", "name": "C0023764#ent", "pos": [6, 7]}}
{"token": ["Recurrent", "C0542142#ent", "<e1>", "hypoparathyroidism", "are", "the", "most", "common", "and", "serious", "complications", "after", "C0279175#ent", "<e2>"], "h": {"id": "C0542142", "name": "C0542142#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0279175", "name": "C0279175#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "24", "cases", "of", "idiopathic", "sudden", "progressive", "deafness", "C2609259#ent", "<e1>", ")", "in", "which", "worsening", "of", "C4021534#ent", "<e2>", "initial", "examination", "was", "confirmed", "by", "audiometry", "."], "h": {"id": "C2609259", "name": "C2609259#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4021534", "name": "C4021534#ent", "pos": [16, 17]}}
{"token": ["There", "was", "reasonable", "agreement", "between", "the", "total", "concentrations", "of", "C0002062#ent", "<e1>", "in", "tinctures", "and", "liquid", "extracts", "C0022046#ent", "<e2>", "determined", "by", "the", "spectrofluorimetric", "method", "and", "by", "the", "titrimetric", "procedure", "of", "the", "British", "Pharmacopoeia"], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022046", "name": "C0022046#ent", "pos": [16, 17]}}
{"token": ["Other", "agents", "which", "are", "cardiotoxic", "and", "which", "have", "profound", "public", "health", "include", "the", "C0002062#ent", "<e1>", "emetine", "in", "C0022046#ent", "<e2>", "cocaine", ",", "and", "ethyl", "alcohol"], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022046", "name": "C0022046#ent", "pos": [17, 18]}}
{"token": ["The", "relationship", "between", "severe", "C3714496#ent", "<e1>", "RAD", ")", "and", "gastroesophageal", "reflux", "disease", "C0017168#ent", "<e2>", ")", "has", "been", "noted", "but", "the", "relationship", "is", "poorly", "understood", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "the", "prevalence", "of", "gastroesophageal", "reflux", "C0017168#ent", "<e1>", ")", "symptoms", "in", "patients", "with", "C3714496#ent", "<e2>", "and", "the", "association", "of", "C0017168#ent", "<e1>", "symptoms", "with", "the", "severity", "of", "airways", "obstruction", "assessed", "by", "pulmonary", "function", "tests", "PFTs", ")", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [7, 8]}}
{"token": ["C0003211#ent", "<e1>", "bound", "to", "both", "the", "N-", "and", "C-terminal", "halves", "the", "C3539609#ent", "<e2>", ",", "and", "the", "affinities", "determined", "were", "similar", "to", "the", "values", "previously", "reported", "for", "the", "full-length", "C3539609#ent", "<e2>", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539609", "name": "C3539609#ent", "pos": [11, 12]}}
{"token": ["Block", "of", "C0599295#ent", "<e1>", "with", "cisapride", "after", "channel", "activation", "C1336930#ent", "<e2>"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336930", "name": "C1336930#ent", "pos": [9, 10]}}
{"token": ["C0220821#ent", "<e1>", "agonist", "and", "antagonist", "modulation", "of", "C3539699#ent", "<e2>", "+", "inward", "currents", "was", "assessed", "after", "coexpression", "of", "chimeric", "and", "mutant", "calcium", "channel", "alpha1", "subunits", "alpha2delta", "and", "beta1a", "subunits", "in", "Xenopus", "oocytes"], "h": {"id": "C0220821", "name": "C0220821#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [7, 8]}}
{"token": ["C1412535#ent", "<e1>", "and", "Phox2b", "transactivate", "the", "promoter", "of", "the", "gene", "encoding", "the", "noradrenergic", "biosynthetic", "enzyme", ",", "C1413916#ent", "<e2>", "DBH", ")", ",", "and", "dHAND", "potentiates", "the", "activity", "of", "C1412535#ent", "<e1>", "."], "h": {"id": "C1413916", "name": "C1413916#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412535", "name": "C1412535#ent", "pos": [0, 1]}}
{"token": ["These", "findings", "represent", "the", "first", "described", "role", "for", "C1334294#ent", "<e1>", "bZIP", "proteins", "the", "regulation", "of", "a", "C0079429#ent", "<e2>", "involved", "in", "the", "execution", "of", "apoptosis", "."], "h": {"id": "C1334294", "name": "C1334294#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["Antibiotic", "therapy", "during", "C0017677#ent", "<e1>", "often", "protective", "with", "regard", "to", "C0029166#ent", "<e2>"], "h": {"id": "C0017677", "name": "C0017677#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [10, 11]}}
{"token": ["1", ")", "In", "low", "ionic", "strength", "buffer", "C1456390#ent", "<e1>", "increases", "the", "rates", "of", "Ca2", "+", "and", "C1333909#ent", "<e2>", "+", "dissociation", "from", "G-actin", "250-", "and", "50-fold", ",", "respectively", "."], "h": {"id": "C1456390", "name": "C1456390#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [16, 17]}}
{"token": ["We", "suggest", "that", "under", "oxidative", "stress", "C1415335#ent", "<e1>", "is", "activated", "through", "direct", "S-thiolation", "of", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C1415335", "name": "C1415335#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["Consequently", ",", "C0011875#ent", "<e1>", "retinopathy", "and", "nephropathy", ")", "and", "macrovascular", "complications", "(", "coronary", "heart", "disease", "C0085096#ent", "<e2>", "cerebrovascular", "disease", "are", "also", "rising", "."], "h": {"id": "C0011875", "name": "C0011875#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [15, 16]}}
{"token": ["It", "represents", "a", "major", "cause", "of", "morbidity", "and", "mortality", ",", "often", "brought", "about", "by", "C0011875#ent", "<e1>", "retinopathy", ",", "nephropathy", "and", "neuropathy", ")", "and", "macrovascular", "(", "C0085096#ent", "<e2>", "cardiovascular", "disease", "stroke", ")", "complications", "."], "h": {"id": "C0011875", "name": "C0011875#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [25, 26]}}
{"token": ["These", "results", "suggest", "that", "C0023863#ent", "<e1>", "can", "protect", "neurons", "against", "iron-induced", "cell", "death", "might", "thus", "be", "C0242912#ent", "<e2>", "in", "Parkinson's", "disease"], "h": {"id": "C0023863", "name": "C0023863#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [16, 17]}}
{"token": ["We", "have", "examined", "several", "compounds", "including", "dopamine", "receptor", "agonist", "bromocritine", "C0023863#ent", "<e1>", ",", "pergolide", "and", "R-apomorphine", "for", "their", "C0242912#ent", "<e2>", "the", "above", "neurotoxins", "in", "PC12", "and", "dopamine", "neuroblastoma", "cell", "lines", "in", "culture", "and", "in", "vivo"], "h": {"id": "C0023863", "name": "C0023863#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [18, 19]}}
{"token": ["Discordance", "was", "associated", "with", "C0019693#ent", "<e1>", "not", "with", "C2314882#ent", "<e2>"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "no", "pharmacokinetic", "interaction", "was", "observed", "when", "C0751039#ent", "<e1>", "was", "intravenously", "administered", "in", "rats", "dosed", "orally", "with", "C1415467#ent", "<e2>", ",", "suggesting", "that", "C1415467#ent", "<e2>", "did", "not", "affect", "hepatic", "metabolism"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415467", "name": "C1415467#ent", "pos": [19, 20]}}
{"token": ["After", "oral", "coadministration", "of", "C0751039#ent", "<e1>", "with", "100", "microg/kg", "and", "200", "microg/kg", "C1415467#ent", "<e2>", ",", "bioavailability", "(", "BA", ")", "was", "significantly", "increased", ",", "compared", "with", "control", "rats"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415467", "name": "C1415467#ent", "pos": [12, 13]}}
{"token": ["Plasma", "renin", "and", "norepinephrine", "(", "NE", ")", "levels", "increased", "after", "C0060180#ent", "<e1>", "in", "both", "control", "and", "C0018802#ent", "<e2>", "rabbits", "."], "h": {"id": "C0060180", "name": "C0060180#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}}
{"token": ["C0060180#ent", "<e1>", "ameliorates", "some", "of", "the", "adverse", "hemodynamic", "changes", "that", "occur", "during", "C0018802#ent", "<e2>", "does", "not", "reduce", "right", "heart", "filling", "as", "does", "nitroprusside", "."], "h": {"id": "C0060180", "name": "C0060180#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}}
{"token": ["Crude", "and", "partly", "purified", "extracts", "Helix", "pomatia", "C0065000#ent", "<e1>", "from", "cassava", "were", "C2350558#ent", "<e2>", "on", "columns", "packed", "with", "porous", "glass", "or", "silica", "and", "used", "as", "post-column", "reactors", "in", "the", "high-performance", "liquid", "chromatography", "cyanogenic", "glycosides"], "h": {"id": "C0065000", "name": "C0065000#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "the", "aryl", "hydrocarbon", "receptor", "C1706481#ent", "<e1>", ")", ",", "a", "basic", "C3273649#ent", "<e2>", "in", "lymphocytes", "by", "the", "immunosuppressive", "environmental", "contaminant", "2,3,7,8,-tetrachlorodibenzo-p-dioxin", "TCDD", ")", "has", "been", "shown", "to", "cause", "thymic", "atrophy", "every", "species", "studied", "."], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273649", "name": "C3273649#ent", "pos": [12, 13]}}
{"token": ["Extracellular", "calcium", "opposed", "C0020223#ent", "<e1>", "action", "by", "a", "mechanism", "sensitive", "to", "C0085387#ent", "<e2>"], "h": {"id": "C0020223", "name": "C0020223#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [11, 12]}}
{"token": ["Spleen", "enlargement", "is", "commonly", "associated", "with", "portal", "hypertension", "C1623038#ent", "<e1>", "and", "may", "cause", "C0040034#ent", "<e2>", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [13, 14]}}
{"token": ["C0040558#ent", "<e1>", ",", "caused", "by", "Toxoplasma", "gondii", "is", "an", "important", "C0030499#ent", "<e2>", ",", "which", "causes", "widespread", "human", "and", "animal", "diseases"], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [10, 11]}}
{"token": ["This", "study", "presents", "evidence", "that", "PBLs", "from", "healthy", "donors", "to", "sonicated", "Mycobacterium", "tuberculosis", "C0796126#ent", "<e1>", "with", "increased", "IL-4", "gene", ",", "C1705984#ent", "<e2>", "expression", ",", "and", "apoptosis", "."], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705984", "name": "C1705984#ent", "pos": [20, 21]}}
{"token": ["Here", ",", "we", "analyze", "the", "cell", "cycle", "kinetic", "effects", "of", "exposure", "to", "camptothecin", ",", "C0002699#ent", "<e1>", ",", "netropsin", ",", "distamycin", "A", "and", "C0105753#ent", "<e2>", "by", "using", "continuous", "bromodeoxyuridine", "labeling", "by", "bivariate", "Hoechst", "33258/ethidium", "bromide", "flow", "cytometry", "."], "h": {"id": "C0002699", "name": "C0002699#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0105753", "name": "C0105753#ent", "pos": [22, 23]}}
{"token": ["We", "have", "previously", "demonstrated", "that", "the", "human", "liver-specific", "antigen", "HLSA", ")", "expression", "was", "enhanced", "and", "C0086661#ent", "<e1>", "levels", "were", "reduced", "during", "C3714642#ent", "<e2>", "butyrate-induced", "differentiation", "in", "human", "hepatoma", "cells"], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [21, 22]}}
{"token": ["C1540309#ent", "<e1>", "is", "a", "B-cell-specific", "member", "of", "the", "C1334163#ent", "<e2>", "is", "expressed", "throughout", "B-cell", "development", "with", "the", "earliest", "precursor", "B", "cells", "immunoglobulin", "heavy-chain", "gene", "segment", "rearrangements"], "h": {"id": "C1540309", "name": "C1540309#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334163", "name": "C1334163#ent", "pos": [8, 9]}}
{"token": ["Large", "randomized", "trials", "shown", "that", "intramuscular", "(", "IM", ")", "delivery", "of", "C0962603#ent", "<e1>", "is", "safe", "and", "effective", "in", "treating", "plaque", "C0033860#ent", "<e2>", "."], "h": {"id": "C0962603", "name": "C0962603#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [20, 21]}}
{"token": ["The", "EXT", "family", "of", "C0079427#ent", "<e1>", "endochondral", "bone", "growth", "and", "mutations", "in", "EXT1", "and", "C0694879#ent", "<e2>", "the", "autosomal", "dominant", "disorder", "Hereditary", "Multiple", "Exostoses", "HME", ")", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0694879", "name": "C0694879#ent", "pos": [14, 15]}}
{"token": ["Various", "germline", "mutations", "two", "C0079427#ent", "<e1>", "EXT1", "localized", "to", "8q24.1", "and", "C0694879#ent", "<e2>", "localized", "to", "11p11", "approximately", "p12", ",", "have", "been", "demonstrated", "in", "HME", "families", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0694879", "name": "C0694879#ent", "pos": [11, 12]}}
{"token": ["Based", "on", "these", "catalytic", "activities", "is", "proposed", "that", "this", "novel", "membrane", "protein", "a", "member", "of", "the", "C1417146#ent", "<e1>", "which", "also", "includes", "microsomal", "GST-I", "LTC4", "synthase", "FLAP", ",", "and", "C1701621#ent", "<e2>"], "h": {"id": "C1417146", "name": "C1417146#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1701621", "name": "C1701621#ent", "pos": [28, 29]}}
{"token": ["Based", "on", "these", "catalytic", "activities", "is", "proposed", "that", "this", "novel", "membrane", "protein", "a", "member", "of", "the", "C1417146#ent", "<e1>", "which", "also", "includes", "C1701621#ent", "<e2>", "LTC4", "synthase", "FLAP", ",", "and", "microsomal", "GST-II"], "h": {"id": "C1417146", "name": "C1417146#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1701621", "name": "C1701621#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "IC1", "is", "a", "novel", "C1425753#ent", "<e1>", "from", "IC2", "and", "C3539699#ent", "<e2>", "and", "may", "be", "a", "multifunctional", "protein"], "h": {"id": "C1425753", "name": "C1425753#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [11, 12]}}
{"token": ["The", "downregulation", "of", "C3273437#ent", "<e1>", "correlated", "with", "the", "amelioration", "of", "C3714636#ent", "<e2>", "as", "indicated", "by", "reductions", "in", "leukocyte", "infiltration", "by", "43", "%", ")", "and", "intra-alveolar", "septal", "thickening", "(", "by", "40", "%", ")", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [10, 11]}}
{"token": ["Both", "its", "ability", "to", "target", "CYP", "C0017337#ent", "<e1>", "and", "its", "activation", "by", "C0207497#ent", "<e2>", "demonstrate", "that", "CAR", "is", "a", "novel", "xenobiotic", "receptor", "may", "contribute", "to", "the", "metabolic", "response", "such", "compounds", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0207497", "name": "C0207497#ent", "pos": [12, 13]}}
{"token": ["This", "observation", "also", "confirmed", "that", ",", "as", "in", "de", "novo", "C0812385#ent", "<e1>", ",", "both", "the", "P190", "and", "P210", "varieties", "of", "C1835417#ent", "<e2>", "mRNA", "are", "observed", "in", "C0812385#ent", "<e1>", "with", "late-appearing", "Ph1", "."], "h": {"id": "C1835417", "name": "C1835417#ent", "pos": [20, 21]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [10, 11]}}
{"token": ["Both", "C1835417#ent", "<e1>", "transcripts", "derive", "their", "5", "'", "non-coding", "sequences", "the", "C0812385#ent", "<e2>"], "h": {"id": "C1835417", "name": "C1835417#ent", "pos": [1, 2]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "in", "general", ",", "blood", "and", "marrow", "contain", "similar", "C1835417#ent", "<e1>", "transcript", "numbers", "in", "Ph-positive", "C0812385#ent", "<e2>", "but", "some", "samples", "are", "discordant", "."], "h": {"id": "C1835417", "name": "C1835417#ent", "pos": [11, 12]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [17, 18]}}
{"token": ["Evidence", "for", "the", "involvement", "of", "basement", "membrane-degrading", "matrix", "metalloproteinases", "C3494976#ent", "<e1>", ")", "and", "growth", "factors", "mediating", "C3888088#ent", "<e2>", "migration", "and", "proliferation", "has", "been", "presented", "in", "a", "number", "of", "in", "vitro", "in", "vivo", "models", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [16, 17]}}
{"token": ["Matrix", "metalloproteinases", "C3494976#ent", "<e1>", ")", "play", "a", "key", "role", "in", "these", "processes", "of", "C3888088#ent", "<e2>", "migration", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [13, 14]}}
{"token": ["The", "results", "showed", "that", "IFN-gamma", "plus", "LPS", "can", "indeed", "stimulate", "TNF", "and", "IL-1", "secretion", "by", "C3813124#ent", "<e1>", "and", "PBM", "from", "patients", "with", "C1647218#ent", "<e2>", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [22, 23]}}
{"token": ["The", "D368A", "mutation", "within", "the", "C0950448#ent", "<e1>", "the", "herpes", "simplex", "type", "1", "DNA", "polymerase", "this", "C0597094#ent", "<e2>", "and", "severely", "interferes", "with", "virus", "viability"], "h": {"id": "C0950448", "name": "C0950448#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597094", "name": "C0597094#ent", "pos": [15, 16]}}
{"token": ["Eight", "patients", "with", "C0393484#ent", "<e1>", "epilepsia", "partialis", "continua", "treated", "with", "high", "doses", "steroids", ",", "including", "pulses", "of", "C0360556#ent", "<e2>", "and", "prednisone", "in", "decreasing", "doses", "."], "h": {"id": "C0393484", "name": "C0393484#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0360556", "name": "C0360556#ent", "pos": [17, 18]}}
{"token": ["Our", "data", "support", "a", "model", "in", "which", "Plp2p", "modulates", "the", "biogenesis", "of", "several", "CCT", "substrates", "relating", "to", "cell", "cycle", "C1333200#ent", "<e1>", "which", "together", "contribute", "to", "the", "essential", "function", "C1418655#ent", "<e2>", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418655", "name": "C1418655#ent", "pos": [28, 29]}}
{"token": ["C1413179#ent", "<e1>", "a", "nuclear", "localization", "all", "interphase", "cells", "clear", "absence", "from", "C1417613#ent", "<e2>", "."], "h": {"id": "C1413179", "name": "C1413179#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [11, 12]}}
{"token": ["Together", ",", "these", "results", "show", "that", "activation", "of", "group", "III", "mGluRs", "in", "the", "C1705433#ent", "<e1>", "provides", "benefits", "in", "C0242422#ent", "<e2>", "rats", ",", "presumably", "by", "modulating", "GABAergic", "neurotransmission", "."], "h": {"id": "C1705433", "name": "C1705433#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [18, 19]}}
{"token": ["The", "tissue", "activities", "P-Rib-PP", "amidotransferase", ",", "xanthine", "dehydrogenase", "C0001503#ent", "<e1>", "lyase", ",", "AMP", "deaminase", "IMP", "dehydrogenase", "and", "C0061779#ent", "<e2>", "not", "rise", "in", "livers", "from", "estradiol-treated", "chicks", ",", "as", "compared", "to", "controls", "."], "h": {"id": "C0001503", "name": "C0001503#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0061779", "name": "C0061779#ent", "pos": [17, 18]}}
{"token": ["Nucleotide", "interconversion", "enzymes", "adenylosuccinate", "lyase", "EC", "4.3.2.2", ";", "C0001503#ent", "<e1>", "EC", "6.3.4.4", ";", "IMP", "dehydrogenase", "EC", "1.2.1.14", ";", "C0061779#ent", "<e2>", "EC", "6.3.5.2", "and", "GMP", "reductase", "EC", "1.6.6.8", ")", "were", "not", "detected", "."], "h": {"id": "C0001503", "name": "C0001503#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0061779", "name": "C0061779#ent", "pos": [18, 19]}}
{"token": ["It", "was", "concluded", "that", "by", "reducing", "twitch", "tension", "inhibiting", "neuromuscular", "transmission", "C0280858#ent", "<e1>", "increases", "(", "intensifies", ")", "neuromuscular", "blockade", "by", "muscle", "relaxants", "e.g.", "C0016971#ent", "<e2>", "and", "pancuronium", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0016971", "name": "C0016971#ent", "pos": [23, 24]}}
{"token": ["Neuronal", "intermediate", "filament", "IF", ")", "inclusion", "disease", "NIFID", ")", "is", "a", "novel", "C0752235#ent", "<e1>", "early", "onset", "a", "variable", "clinical", "phenotype", "including", "C0236642#ent", "<e2>", "pyramidal", ",", "and", "extrapyramidal", "signs"], "h": {"id": "C0752235", "name": "C0752235#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0236642", "name": "C0236642#ent", "pos": [21, 22]}}
{"token": ["The", "case", "lacked", "both", "a", "known", "family", "history", "a", "similar", "C0752235#ent", "<e1>", "the", "typical", "EEG", "pattern", ";", "it", "was", "misdiagnosed", "as", "C0236642#ent", "<e2>"], "h": {"id": "C0752235", "name": "C0752235#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0236642", "name": "C0236642#ent", "pos": [21, 22]}}
{"token": ["The", "results", "indicate", "that", "C1333723#ent", "<e1>", "is", "rapidly", "induced", "in", "hepatocytes", "of", "intoxicated", "animals", "preceding", "C1417048#ent", "<e2>", "formation", "."], "h": {"id": "C1333723", "name": "C1333723#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [15, 16]}}
{"token": ["Using", "2D", "gel", "electrophoresis", "mass", "spectrometry", "we", "identified", "C1333723#ent", "<e1>", "as", "a", "novel", "C1417048#ent", "<e2>", "component", "."], "h": {"id": "C1333723", "name": "C1333723#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [13, 14]}}
{"token": ["The", "relationship", "of", "C0038363#ent", "<e1>", "the", "appearance", "of", "the", "colon", "in", "14", "patients", "with", "C0010346#ent", "<e2>", "determined", "by", "retrospective", "evaluation", "radiographs", "obtained", "over", "several", "years", "during", "which", "various", "therapeutic", "regimens", "been", "undertaken", "."], "h": {"id": "C0038363", "name": "C0038363#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [14, 15]}}
{"token": ["BACKGROUND-Prostate-specific", "antigen", "(", "C1418948#ent", "<e1>", ")", ",", "acid", "phosphatase", "AP", ")", ",", "and", "C0312402#ent", "<e2>", "PAP", ")", "are", "serum", "markers", "adenocarcinoma", "of", "the", "prostate", "gland"], "h": {"id": "C1418948", "name": "C1418948#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0312402", "name": "C0312402#ent", "pos": [13, 14]}}
{"token": ["In", "a", "second", "series", "of", "studies", ",", "C0064465#ent", "<e1>", "but", "not", "L-365,260", "antagonized", "the", "C0003620#ent", "<e2>", "effect", "of", "either", "d-fenfluramine", "or", "systemically", "administered", "5-HT", "."], "h": {"id": "C0064465", "name": "C0064465#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "report", "an", "interaction", "uncovered", "in", "this", "screening", "with", "C3815886#ent", "<e1>", ",", "a", "mammalian", "C1419922#ent", "<e2>", "may", "function", "as", "a", "phospholipid", "transfer", "protein"], "h": {"id": "C3815886", "name": "C3815886#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419922", "name": "C1419922#ent", "pos": [15, 16]}}
{"token": ["Using", "equimolar", "tryptophan", "and", "C3536850#ent", "<e1>", "concentrations", ",", "all", "C0005064#ent", "<e2>", "with", "binding", "constants", "higher", "than", "10(4", ")", "(", "M(-1", ")", ",", "displace", "L-tryptophan", "from", "its", "binding", "site", "a", "high", "degree", "."], "h": {"id": "C3536850", "name": "C3536850#ent", "pos": [4, 5]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [9, 10]}}
{"token": ["An", "increased", "number", "of", "C2698423#ent", "<e1>", "uniquely", "expressed", "alpha3", ",", "C2698300#ent", "<e2>", ",", "and", "LFA-3", ",", "whereas", "alpha2", ",", "alpha4", ",", "alphaVbeta3", ",", "and", "H-CAM", "were", "significantly", "increased", "."], "h": {"id": "C2698423", "name": "C2698423#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2698300", "name": "C2698300#ent", "pos": [10, 11]}}
{"token": ["The", "serum", "potassium", "declined", "slightly", "in", "all", "the", "groups", ";", "the", "greatest", "decline", "was", "recorded", "for", "the", "C0075018#ent", "<e1>", "patients", "with", "prophylactic", "C0016860#ent", "<e2>", "administration", "."], "h": {"id": "C0075018", "name": "C0075018#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [22, 23]}}
{"token": ["Nine", "patients", "in", "the", "C0075018#ent", "<e1>", "and", "13", "in", "the", "LPG", "received", "C0016860#ent", "<e2>", "prophylactically", "prior", "to", "the", "perfusion", "."], "h": {"id": "C0075018", "name": "C0075018#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [12, 13]}}
{"token": ["C0037500#ent", "<e1>", "treatment", "of", "C0276093#ent", "<e2>", "further", "reduced", "endotoxic", "activity"], "h": {"id": "C0037500", "name": "C0037500#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0276093", "name": "C0276093#ent", "pos": [4, 5]}}
{"token": ["All", "three", "children", "were", "adversely", "affected", "by", "the", "C1167662#ent", "<e1>", "of", "the", "C0031485#ent", "<e2>", "each", "with", "evidence", "of", "growth", "failure", "impaired", "neurodevelopment", "."], "h": {"id": "C1167662", "name": "C1167662#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [12, 13]}}
{"token": ["Farnesyl", "pyrophosphate", "synthetase", "C1414564#ent", "<e1>", ";", "EC", "2.5.1.10", ")", "produces", "the", "C3888279#ent", "<e2>", "is", "utilized", "in", "the", "synthesis", "of", "sterols", ",", "carotenoids", ",", "dolichols", ",", "coenzyme", "Q", "heme", "a", "and", "farnesylated", "proteins"], "h": {"id": "C1414564", "name": "C1414564#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3888279", "name": "C3888279#ent", "pos": [11, 12]}}
{"token": ["The", "chief", "C1420706#ent", "<e1>", "interest", "are", "chorionic", "gonadotrophin", "C1413753#ent", "<e2>", "Schwangerschaftsprotein", "1"], "h": {"id": "C1420706", "name": "C1420706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413753", "name": "C1413753#ent", "pos": [8, 9]}}
{"token": ["To", "analyze", "the", "association", "between", "C0002085#ent", "<e1>", "of", "HLA-DRB1", "and", "C0241910#ent", "<e2>", "AIH", ")", "in", "patients", "from", "Shanghai", ",", "China", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0241910", "name": "C0241910#ent", "pos": [10, 11]}}
{"token": ["p300", "formed", "a", "complex", "with", "C1257113#ent", "<e1>", "C1414583#ent", "<e2>", ")", "and", "acetylated", "C1414583#ent", "<e2>", "in", "vitro"], "h": {"id": "C1257113", "name": "C1257113#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414583", "name": "C1414583#ent", "pos": [7, 8]}}
{"token": ["In", "this", "article", ",", "we", "demonstrated", "that", "in", "rat", "C1706229#ent", "<e1>", "the", "transcription", "rates", "of", "both", "pip", "92", "and", "C1416450#ent", "<e2>", "are", "induced", "by", "insulin", "alone", "."], "h": {"id": "C1706229", "name": "C1706229#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416450", "name": "C1416450#ent", "pos": [19, 20]}}
{"token": ["C1333257#ent", "<e1>", "is", "a", "member", "of", "an", "expanding", "family", "of", "C1335554#ent", "<e2>", "amino", "acid", "sequence", "to", "a", "Tyr/Ser-protein", "phosphatase", "encoded", "by", "the", "late", "H1", "gene", "vaccinia", "virus"], "h": {"id": "C1333257", "name": "C1333257#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [10, 11]}}
{"token": ["In", "this", "review", ",", "we", "summarize", "the", "major", "factors", "contributing", "to", "C0037274#ent", "<e1>", "in", "murine", "models", "of", "C0206752#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0206752", "name": "C0206752#ent", "pos": [17, 18]}}
{"token": ["We", "wanted", "to", "investigate", "whether", "treatment", "with", "the", "C1134681#ent", "<e1>", "LU", "135252", "or", "with", "the", "angiotensin-converting", "enzyme", "inhibitor", "C0165477#ent", "<e2>", "might", "prevent", "angiopathy", "in", "long-term", "type", "I", "diabetes", "mellitus"], "h": {"id": "C1134681", "name": "C1134681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0165477", "name": "C0165477#ent", "pos": [18, 19]}}
{"token": ["The", "effectiveness", "of", "crystalline", "C3853624#ent", "<e1>", "and", "saliva", "in", "hydrolyzing", "newly", "formed", "C0002245#ent", "<e2>", "in", "liver", "and", "muscle", "was", "examined", "."], "h": {"id": "C3853624", "name": "C3853624#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [12, 13]}}
{"token": ["C3538699#ent", "<e1>", "expression", "was", "significantly", "correlated", "with", "the", "inflammatory", "infiltration", "C1704467#ent", "<e2>", "expression", ",", "whereas", "no", "significant", "correlation", "with", "ulceration", ",", "tumor", "thickness", "clinical", "stage", "histopathological", "subtypes", "were", "observed", "."], "h": {"id": "C3538699", "name": "C3538699#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "it", "has", "been", "confirmed", "that", "the", "caspase-3", "specific", "inhibitor", ",", "C0671700#ent", "<e1>", ",", "blocks", "the", "activation", "of", "C1705065#ent", "<e2>", "in", "MNB-treated", "HL-60", "cells"], "h": {"id": "C0671700", "name": "C0671700#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [20, 21]}}
{"token": ["Antianginous", "drugs", "(", "dipyridamole", ",", "propranolol", ",", "C0042523#ent", "<e1>", ",", "nitroglycerin", "and", "C0040779#ent", "<e2>", ")", "induced", "a", "significant", "inhibition", "of", "the", "U", "46619", "effects", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040779", "name": "C0040779#ent", "pos": [12, 13]}}
{"token": ["C1739021#ent", "<e1>", "essential", "key", "regulators", "of", "eukaryotic", "cell", "cycle", "progression", "the", "C1332719#ent", "<e2>", "and", "B", "isoforms", "over-expressed", "in", "different", "tumors", "and", "related", "cancer", "cell", "lines"], "h": {"id": "C1739021", "name": "C1739021#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332719", "name": "C1332719#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "we", "present", "evidence", "that", "deregulation", "of", "C1739021#ent", "<e1>", "occurs", "predominantly", "on", "the", "post-transcriptional", "level", "as", "overabundant", "C1332719#ent", "<e2>", "usually", "not", "accompanied", "by", "adequate", "mRNA", "overexpression", "."], "h": {"id": "C1739021", "name": "C1739021#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332719", "name": "C1332719#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "C1421224#ent", "<e1>", "by", "ultrasound", "imaging", "correlation", "between", "C1421224#ent", "<e1>", "and", "C0002726#ent", "<e1>", "sought", "."], "h": {"id": "C1421224", "name": "C1421224#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [12, 13]}}
{"token": ["Hepatocyte", "growth", "factor", "activin", "A", "C1414830#ent", "<e1>", "compose", "an", "intricate", ",", "C2936489#ent", "<e2>", "and", "mostly", "antagonistic", "cytokine", "network", "."], "h": {"id": "C1414830", "name": "C1414830#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936489", "name": "C2936489#ent", "pos": [11, 12]}}
{"token": ["Trimetazidine", "(", "C0076080#ent", "<e1>", ")", "was", "added", "to", "the", "C0007200#ent", "<e2>", "a", "concentration", "of", "10(-6", ")", "M", "in", "two", "additional", "groups", "corresponding", "to", "both", "preservation", "conditions", "."], "h": {"id": "C0076080", "name": "C0076080#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007200", "name": "C0007200#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "dose", "of", "beclomethasone", "inhaler", "50", "micrograms", ")", "or", "C0360097#ent", "<e1>", "10", "%", "spray", "on", "postoperative", "C0242429#ent", "<e2>", "studied", "in", "120", "patients", "undergoing", "tracheal", "intubation", "elective", "surgical", "procedures"], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242429", "name": "C0242429#ent", "pos": [18, 19]}}
{"token": ["The", "C3540471#ent", "<e1>", "is", "to", "investigate", "the", "association", "between", "apolipoprotein", "E", "C1412481#ent", "<e2>", ")", "and", "panic", "disorder", "PD", ")", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [11, 12]}}
{"token": ["C3540471#ent", "<e1>", ":", "To", "investigate", "the", "role", "of", "apolipoprotein", "E", "C1412481#ent", "<e2>", ")", "polymorphism", "in", "the", "lithogenesis", "of", "gallstone", "and", "the", "hereditary", "pathogenesis", "of", "the", "disease", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [10, 11]}}
{"token": ["In", "C0002736#ent", "<e1>", "a", "group", "of", "dominantly", "inherited", "disorders", "C1420306#ent", "<e2>", "precipitates", "are", "found", "."], "h": {"id": "C0002736", "name": "C0002736#ent", "pos": [1, 2]}, "relation": "disease_has_associated_gene", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [9, 10]}}
{"token": ["C0002736#ent", "<e1>", "mutations", "in", "the", "copper-zinc", "superoxide", "dismutase", "C1420306#ent", "<e2>", ")", "gene", "cause", "motor", "neuron", "death", "about", "3", "%", "of", "ALS", "cases", "."], "h": {"id": "C0002736", "name": "C0002736#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [8, 9]}}
{"token": ["In", "a", "study", "in", ">", "5000", "patients", ",", "respective", "healed", "C0014868#ent", "<e1>", "rates", "with", "once-daily", "C0937846#ent", "<e2>", "40", "mg", "or", "lansoprazole", "30", "mg", "were", "92.6", "and", "88.8", "%", "."], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0937846", "name": "C0937846#ent", "pos": [15, 16]}}
{"token": ["Recently", ",", "C1705267#ent", "<e1>", "was", "suggested", "to", "be", "causative", "in", "C0879290#ent", "<e2>", "."], "h": {"id": "C1705267", "name": "C1705267#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0879290", "name": "C0879290#ent", "pos": [10, 11]}}
{"token": ["Most", "IgG4-related", "sclerosing", "diseases", "been", "found", "to", "be", "associated", "with", "C1412302#ent", "<e1>", ",", "but", "also", "those", "without", "C0030304#ent", "<e2>", "involvement", "have", "been", "reported", "."], "h": {"id": "C1412302", "name": "C1412302#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030304", "name": "C0030304#ent", "pos": [17, 18]}}
{"token": ["We", "measured", "C0030946#ent", "<e1>", "activity", "in", "normal", "subjects", "in", "patients", "with", "chronic", "hepatocellular", "disease", "C0341439#ent", "<e2>"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0341439", "name": "C0341439#ent", "pos": [14, 15]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "the", "C1413582#ent", "<e2>", "alpha", "2", "chains", "regulated", "by", "a", "common", "alpha", "130-base", "pair", "(", "bp", ")", "bidirectional", "promoter", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413582", "name": "C1413582#ent", "pos": [5, 6]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "the", "alpha-1", "and", "alpha-2", "chains", "of", "type", "IV", "collagen", "C1413582#ent", "<e2>", "and", "COL4A2", ")", "map", "to", "the", "same", "chromosomal", "band", "13q34", ")", "and", "have", "a", "high", "degree", "of", "nucleotide", "homology"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413582", "name": "C1413582#ent", "pos": [13, 14]}}
{"token": ["Three", "of", "these", "23-oxa", "C0014996#ent", "<e1>", "analogs", "lacking", "the", "typical", "side-chain", "OH", "group", "are", "more", "C1413240#ent", "<e2>", "in", "vitro", "desirably", "less", "calcemic", "in", "vivo", "the", "natural", "hormone"], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [15, 16]}}
{"token": ["This", "C0025132#ent", "<e1>", "antiserum", "(", "I-1", ")", "with", "the", "C1334043#ent", "<e2>", "unmetabolized", "digoxin", "."], "h": {"id": "C0025132", "name": "C0025132#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["However", ",", "a", "poorly", "characterized", "Ras", "mutant", "V12N38", "C0525678#ent", "<e1>", ",", "can", "partially", "repress", "C2347318#ent", "<e2>", "transcriptional", "activity", "an", "ERK-independent", "pathway", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2347318", "name": "C2347318#ent", "pos": [14, 15]}}
{"token": ["Importantly", ",", "concomitant", "expression", "of", "constitutive", "activated", "Raf", "and", "V12N38", "C0525678#ent", "<e1>", "results", "in", "almost", "complete", "loss", "of", "C2347318#ent", "<e2>", "activity", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2347318", "name": "C2347318#ent", "pos": [18, 19]}}
{"token": ["C3273437#ent", "<e1>", "mRNA", "levels", "were", "unchanged", "in", "C2987364#ent", "<e2>", "mice", "throughout", "the", "hyperoxia", "treatment", ",", "suggesting", "that", "C3273437#ent", "<e1>", "mRNA", "expression", "is", "not", "regulated", "by", "the", "increase", "in", "inspired", "oxygen"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [0, 1]}}
{"token": ["Neither", "salicylate", "nor", "C3502823#ent", "<e1>", "induced", "higher", "expression", "of", "C3541394#ent", "<e2>", "for", "1-naphthol", "catabolism", "in", "NCIB", "12038", "and", "NCIB", "12043", "."], "h": {"id": "C3502823", "name": "C3502823#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}}
{"token": ["The", "kinetic", "parameters", "for", "turnover", "of", "C3502823#ent", "<e1>", "by", "the", "C3541394#ent", "<e2>", "are", "nearly", "identical", "(", "kcat/Km", "=", "4.3", "x", "10(6", ")", "s-1", "M-1", ")", "."], "h": {"id": "C3502823", "name": "C3502823#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}}
{"token": ["The", "activity", "of", "C0163611#ent", "<e1>", "in", "the", "C0669372#ent", "<e2>", "was", "also", "increased", "by", "dexamethasone", "."], "h": {"id": "C0163611", "name": "C0163611#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [7, 8]}}
{"token": ["Kawasaki", "disease", "(", "C1705240#ent", "<e1>", ")", "is", "a", "C1848862#ent", "<e2>", "of", "systemic", "vasculitis", "unknown", "etiology", "that", "is", "complicated", "by", "coronary", "artery", "lesions", "CAL", ")", ",", "leading", "occasionally", "to", "cardiac", "ischemic", "sequelae", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [8, 9]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "the", "M2", "subunit", "ribonucleotide", "reductase", "C1335649#ent", "<e2>", ")", ",", "ornithine", "decarboxylase", "ODC1", ")", ",", "and", "55,000-Daltons", "protein", "(", "P5", ")", ",", "are", "amplified", "in", "hydroxyurea-resistant", "hamster", "and", "human", "cell", "lines"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335649", "name": "C1335649#ent", "pos": [9, 10]}}
{"token": ["Receptor-mediated", "activation", "C1382029#ent", "<e1>", "prostaglandin", "E1", "stimulation", "with", "the", "cAMP", "analog", "8-bromo-cAMP", "also", "enhanced", "C1706383#ent", "<e2>", "expression", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [14, 15]}}
{"token": ["Intact", "PTH", "is", "also", "elevated", "in", "C1561643#ent", "<e1>", "but", "less", "dramatically", "than", "in", "C0221002#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [13, 14]}}
{"token": ["Studies", "were", "carried", "out", "to", "determine", "if", "susceptibility", "of", "the", "cereal", "C0885100#ent", "<e1>", "Metopolophium", "dirhodum", "the", "fungus", "Pandora", "neoaphidis", "affected", "by", "wheat", "expressing", "snowdrop", "lectin", "C2703069#ent", "<e2>", ")", "."], "h": {"id": "C0885100", "name": "C0885100#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2703069", "name": "C2703069#ent", "pos": [25, 26]}}
{"token": ["Specifically", ",", "Cdc42(D38E)p", "showed", "reduced", "interactions", "with", "the", "C1568884#ent", "<e1>", "the", "Bem3p", "GTPase-activating", "protein", "cdc42(D38E", ")", "was", "the", "only", "mutant", "C0002085#ent", "<e2>", "able", "to", "complement", "the", "Deltacdc42", "null", "mutant"], "h": {"id": "C1568884", "name": "C1568884#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [20, 21]}}
{"token": ["The", "site", "of", "C1424615#ent", "<e1>", "expression", "in", "late", "embryonic", "heart", "with", "the", "location", "of", "the", "C1825840#ent", "<e2>", "node", "in", "postnatal", "and", "adult", "heart", "[", "Cardiovasc", "."], "h": {"id": "C1424615", "name": "C1424615#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", "to", "C1538879#ent", "<e1>", "phosphorylation", "is", "required", "for", "DNA", "binding", "C1419420#ent", "<e2>", "."], "h": {"id": "C1538879", "name": "C1538879#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419420", "name": "C1419420#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "activation", "of", "the", "p53", "protein", "increases", "the", "transcription", "of", "the", "HTRA2", "gene", "which", "encodes", "a", "C2717971#ent", "<e1>", "interacts", "with", "C1332414#ent", "<e2>", "and", "potentiates", "apoptosis", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1332414", "name": "C1332414#ent", "pos": [21, 22]}}
{"token": ["Differential", "diagnoses", "C0458101#ent", "<e1>", "hemicrania", "continua", "chronic", "paroxysmal", "hemicrania", "occipital", "neuralgia", "migraine", "and", "C0723643#ent", "<e2>"], "h": {"id": "C0458101", "name": "C0458101#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0723643", "name": "C0723643#ent", "pos": [13, 14]}}
{"token": ["The", "relative", "order", "of", "potencies", "was", "C0000589#ent", "<e1>", "greater", "than", "5-hydroxytryptoline", "greater", "than", "C0077436#ent", "<e2>", "."], "h": {"id": "C0000589", "name": "C0000589#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0077436", "name": "C0077436#ent", "pos": [13, 14]}}
{"token": ["All", "four", "C0031727#ent", "<e1>", "were", "activated", "in", "thrombin-stimulated", "platelets", "whereas", "only", "SAPK2a", "and", "C1456378#ent", "<e2>", "were", "significantly", "stimulated", "by", "collagen", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [13, 14]}}
{"token": ["The", "extracellular", "signal", "regulated", "C0031727#ent", "<e1>", "and", "the", "C1456378#ent", "<e2>", "MAP", ")", "kinases", "were", "selectively", "required", "for", "TCR", "and", "cytokine-driven", "proliferation", ",", "respectively", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "inhibition", "rate", "of", "C0028066#ent", "<e1>", "plus", "C0065538#ent", "<e2>", "on", "muscle", "strips", "was", "lower", "than", "that", "of", "C0028066#ent", "<e1>", "alone", "."], "h": {"id": "C0065538", "name": "C0065538#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "the", "downstream", "sequences", "of", "the", "lytA", "gene", "were", "C1512488#ent", "<e1>", "to", "the", "phage", "attachment", "site", "C1823589#ent", "<e2>", ")", "of", "the", "phage", "phi", "11"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1823589", "name": "C1823589#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "C1335071#ent", "<e1>", "phosphorylation", "at", "serine", "5", "a", "hallmark", "of", "the", "initiating", "C1335440#ent", "<e2>", ",", "but", "not", "at", "serine", "2", "a", "hallmark", "of", "the", "elongating", "polymerase", "completely", "inhibits", "ubiquitylation", "."], "h": {"id": "C1335071", "name": "C1335071#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [13, 14]}}
{"token": ["The", "C1335071#ent", "<e1>", "is", "unphosphorylated", "when", "the", "C1335440#ent", "<e2>", "assembles", "into", "a", "preinitiation", "complex", "transcription", "and", "becomes", "heavily", "phosphorylated", "during", "promoter", "clearance", "and", "entry", "into", "elongation", "of", "transcription", "."], "h": {"id": "C1335071", "name": "C1335071#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [7, 8]}}
{"token": ["ET-1", "levels", "remain", "elevated", "when", "C0003211#ent", "<e1>", "fail", "to", "interrupt", "left-to-right", "PDA", "shunting", "complicates", "recovery", "from", "C1826711#ent", "<e2>", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826711", "name": "C1826711#ent", "pos": [16, 17]}}
{"token": ["Caspase", "assays", "revealed", "a", "strong", "induction", "of", "C1413132#ent", "<e1>", "not", "of", "the", "C1720986#ent", "<e2>"], "h": {"id": "C1413132", "name": "C1413132#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1720986", "name": "C1720986#ent", "pos": [12, 13]}}
{"token": ["The", "onset", "of", "C0011860#ent", "<e1>", "not", "influence", "the", "O-dealkylations", "of", "methoxyresorufin", ",", "ethoxyresorufin", "and", "C0070319#ent", "<e2>", "in", "either", "kidney", "or", "lung", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0070319", "name": "C0070319#ent", "pos": [14, 15]}}
{"token": ["This", "study", "determined", "the", "coronary", "microvascular", "resistance", "infarct-related", "arteries", "(", "C1425233#ent", "<e1>", ")", "and", "non-IRAs", "during", "C0155626#ent", "<e2>", "and", "at", "follow-up", "in", "patients", "who", "were", "treated", "with", "primary", "percutaneous", "intervention"], "h": {"id": "C1425233", "name": "C1425233#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [16, 17]}}
{"token": ["Comparative", "data", "from", "patients", "with", "C0700345#ent", "<e1>", "that", "itraconazole", "is", "at", "least", "as", "effective", "as", "intravaginal", "clotrimazole", "C0016277#ent", "<e2>", "and", "superior", "to", "intravaginal", "econazole", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "discuss", "the", "difficulties", "in", "the", "treatment", "of", "recurrent", "C0700345#ent", "<e1>", "the", "advantages", "of", "the", "sequential", "type", "of", "therapy", "with", "C0016277#ent", "<e2>", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [21, 22]}}
{"token": ["Of", "patients", "who", "had", "received", "previous", "intravaginal", "therapy", "C0700345#ent", "<e1>", "88", "per", "cent", "preferred", "C0016277#ent", "<e2>", ",", "10", "per", "cent", "previous", "therapy", "and", "two", "per", "cent", "had", "no", "preference"], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "myocardial", "perfusion", "deficits", "patients", "with", "proven", "C1956346#ent", "<e1>", "a", "saturation", "recovery", "true", "C0385569#ent", "<e2>", "perfusion", "sequence", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0385569", "name": "C0385569#ent", "pos": [20, 21]}}
{"token": ["To", "investigate", "the", "possibility", "that", "anti-La", "(", "SS-B", ")", "antibodies", "in", "Sj\u00f6gren's", "syndrome", "induced", "by", "C0042769#ent", "<e1>", "studied", "the", "distribution", "of", "C1420423#ent", "<e2>", "in", "virus-infected", "human", "cell", "lines"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [21, 22]}}
{"token": ["The", "C1422073#ent", "<e1>", "chaperone", "trigger", "factor", "(", "C1442762#ent", "<e2>", ")", "assists", "the", "folding", "of", "newly", "synthesized", "cytosolic", "proteins", "Escherichia", "coli"], "h": {"id": "C1422073", "name": "C1422073#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1442762", "name": "C1442762#ent", "pos": [7, 8]}}
{"token": ["This", "indicates", "that", "the", "C-domain", "of", "trigger", "factor", "may", "not", "be", "essential", "for", "the", "C1422073#ent", "<e1>", "molecular", "chaperone", "function", "of", "C1442762#ent", "<e2>", "."], "h": {"id": "C1422073", "name": "C1422073#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1442762", "name": "C1442762#ent", "pos": [20, 21]}}
{"token": ["The", "C1422073#ent", "<e1>", "chaperone", "trigger", "factor", "(", "C1442762#ent", "<e2>", ")", "of", "Escherichia", "coli", "with", "a", "variety", "of", "newly", "synthesized", "polypeptides", "to", "assist", "their", "correct", "folding", "."], "h": {"id": "C1422073", "name": "C1422073#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1442762", "name": "C1442762#ent", "pos": [7, 8]}}
{"token": ["The", "zinc", "finger", "domain", "C1705504#ent", "<e1>", "interacts", "with", "the", "NID", "repeats", "C1334885#ent", "<e2>", ",", "a", "region", "essential", "for", "the", "cytoplamic", "localization", "homo-", "and", "heterodimerization", "of", "C1334885#ent", "<e2>", "."], "h": {"id": "C1705504", "name": "C1705504#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334885", "name": "C1334885#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "intramuscular", "injections", "of", "C0038627#ent", "<e1>", "with", "or", "without", "C0004259#ent", "<e2>", "on", "heart", "rate", "rhythm", "were", "studied", "in", "50", "unpremedicated", "children", "6", "-", "18", "months", "of", "age", "."], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [11, 12]}}
{"token": ["Administration", "of", "C0004259#ent", "<e1>", "20", "micrograms.kg-1", "prior", "to", "C0038627#ent", "<e2>", "provides", "no", "advantage", "over", "C0004259#ent", "<e1>", "10", "micrograms.kg-1", "in", "older", "children", "terms", "of", "cardiovascular", "stability"], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [2, 3]}}
{"token": ["Understanding", "how", "the", "multidrug", "resistance", "phenotype", "is", "manifest", "in", "human", "cancer", "cells", "require", "insight", "into", "the", "mechanism", "of", "assembly", ",", "C0021699#ent", "<e1>", "and", "intracellular", "trafficking", "of", "human", "P-glycoprotein", "(", "C1823242#ent", "<e2>", ")", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1823242", "name": "C1823242#ent", "pos": [29, 30]}}
{"token": ["C0206997#ent", "<e1>", "accumulates", "in", "human", "platelets", "activated", "by", "C0243192#ent", "<e2>", "."], "h": {"id": "C0206997", "name": "C0206997#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [8, 9]}}
{"token": ["C0029992#ent", "<e1>", "not", "inhibit", "Pf", "MDH", ",", "while", "C0018096#ent", "<e2>", ",", "which", "interacts", "at", "the", "nucleotide", "binding", "site", "oxidoreductases", "and", "shows", "antimalarial", "activity", ",", "inhibited", "Pf", "MDH", "also", "."], "h": {"id": "C0029992", "name": "C0029992#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018096", "name": "C0018096#ent", "pos": [8, 9]}}
{"token": ["Vav/c-Cbl", "interactions", "are", "also", "detectable", "in", "freshly", "isolated", "T", "cells", "gene-targeted", "mice", "that", "lack", "the", "T", "cell-specific", "inhibitory", "receptor", "C1705969#ent", "<e1>", ",", "in", "which", "C1707078#ent", "<e2>", "is", "hyperphosphorylated", "on", "tyrosine", "residues", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1707078", "name": "C1707078#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "suggest", "that", "Dnaja3", "is", "crucial", "for", "mitochondrial", "biogenesis", "at", "least", "in", "part", ",", "through", "its", "chaperone", "activity", "C1418731#ent", "<e1>", "and", "provide", "genetic", "evidence", "the", "necessity", "for", "mitochondrial", "C4049600#ent", "<e2>", "in", "preventing", "DCM", "."], "h": {"id": "C1418731", "name": "C1418731#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4049600", "name": "C4049600#ent", "pos": [29, 30]}}
{"token": ["In", "the", "presence", "of", "phentolamine", ",", "C0033497#ent", "<e1>", "antagonized", "the", "dopamine-induced", "relaxation", "(", "C1419619#ent", "<e2>", "=", "8.54", "+", "/-", "0.07", ")", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419619", "name": "C1419619#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "SR", "58611A", "was", "resistant", "to", "CGP", "20712A", ",", "ICI", "118551", ",", "C0033497#ent", "<e1>", "and", "tetrodotoxin", ",", "but", "was", "antagonized", "by", "alprenolol", "(", "C1419619#ent", "<e2>", "=", "7.01", ")", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419619", "name": "C1419619#ent", "pos": [25, 26]}}
{"token": ["Neither", "cocaine", "plus", "corticosterone", "nor", "cocaine", ",", "corticosterone", "plus", "C0033497#ent", "<e1>", "altered", "the", "inhibition", "(", "C1419619#ent", "<e2>", ":", "6.77", "and", "6.63", ",", "respectively", ")", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419619", "name": "C1419619#ent", "pos": [15, 16]}}
{"token": ["This", "response", "was", "inhibited", "by", "C0033497#ent", "<e1>", ",", "the", "beta", "1-", "and", "beta", "2-adrenoceptor", "antagonist", "with", "a", "C1419619#ent", "<e2>", "of", "9.20", "suggesting", "that", "the", "prejunctional", "beta-adrenoceptors", "are", "not", "of", "the", "beta", "3-subtype", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419619", "name": "C1419619#ent", "pos": [17, 18]}}
{"token": ["Hepatic", "failure", "evaluated", "by", "measuring", "plasma", "glucose", "ammonia", ",", "bilirubin", ",", "aspartate", "transaminase", "AST", ")", ",", "C0057041#ent", "<e1>", "ALT", ")", ",", "sorbitol", "dehydrogenase", "SDH", ")", ",", "C2744579#ent", "<e2>", "glycogen", ",", "and", "by", "histological", "and", "histomorphometric", "analyses"], "h": {"id": "C0057041", "name": "C0057041#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [26, 27]}}
{"token": ["In", "conclusion", ",", "besides", "elements", "of", "the", "C1366488#ent", "<e1>", "human", "keratinocytes", "show", "high", "levels", "of", "C3536709#ent", "<e2>", "metabolizing", "activity", "."], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [15, 16]}}
{"token": ["Twenty", "patients", "with", "severe", "C0033860#ent", "<e1>", "were", "treated", "with", "oral", "administration", "5", "mg/kg/day", "of", "cyclosporin", "A", "C0010592#ent", "<e2>", ")", "for", "12", "weeks", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [16, 17]}}
{"token": ["A", "variety", "of", "systemically", "administered", "drugs", "are", "used", "to", "treat", "C0033860#ent", "<e1>", ",", "including", "methotrexate", ",", "C0010592#ent", "<e2>", ",", "acitretin", ",", "and", "hydroxyurea", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [16, 17]}}
{"token": ["In", "particular", "C1705751#ent", "<e1>", "is", "able", "to", "facilitate", "C1706334#ent", "<e2>", "release", "and", "to", "decrease", "the", "mRNA", "levels", "of", "this", "decapeptide", "."], "h": {"id": "C1705751", "name": "C1705751#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706334", "name": "C1706334#ent", "pos": [8, 9]}}
{"token": ["In", "this", "context", "the", "C0023899#ent", "<e1>", "is", "discussed", "because", "the", "secretion", "of", "C3539768#ent", "<e2>", "be", "initiated", "during", "an", "acute", "phase", "response"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [12, 13]}}
{"token": ["A", "5-year-old", "girl", "with", "C0812385#ent", "<e1>", "was", "shown", "to", "have", "a", "leukemic", "clone", "by", "a", "C4022022#ent", "<e2>", "and", "quadruplication", "of", "chromosome", "21", "arranged", "in", "tandem", ",", "at", "diagnosis", "and", "relapse", ",", "respectively", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4022022", "name": "C4022022#ent", "pos": [15, 16]}}
{"token": ["The", "anaerobic", "energy", "production", "the", "first", "105", "s", "of", "C1427805#ent", "<e1>", "and", "150", "s", "of", "C1705044#ent", "<e2>", "was", "lower", "(", "P", "<", "0.05", ")", "than", "in", "EX1", "."], "h": {"id": "C1427805", "name": "C1427805#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705044", "name": "C1705044#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "the", "genetic", "absence", "C1418609#ent", "<e1>", "did", "not", "affect", "dsRNA", "+", "IFN-gamma-induced", "C1968833#ent", "<e2>", "expression", ",", "nitric", "oxide", "production", ",", "or", "the", "inhibitory", "actions", "of", "these", "agents", "on", "glucose-stimulated", "insulin", "secretion"], "h": {"id": "C1418609", "name": "C1418609#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [13, 14]}}
{"token": ["CD69", "is", "an", "early", "C1413226#ent", "<e1>", "T", "cells", "cross-linking", "of", "CD69", "on", "platelets", "triggers", "aggregation", "and", "C0127400#ent", "<e2>"], "h": {"id": "C1413226", "name": "C1413226#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [16, 17]}}
{"token": ["Hypersensitivity", "angiitis", "microscopic", "polyarteritis", "nodosa", "one", "of", "the", "C0042384#ent", "<e1>", "was", "not", "distinguished", "from", "classic", "C0031036#ent", "<e2>", "the", "Fifties", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0031036", "name": "C0031036#ent", "pos": [15, 16]}}
{"token": ["Waardenburg", "syndrome", "C0175702#ent", "<e1>", ")", "is", "an", "inherited", "C0452138#ent", "<e2>", "condition", "in", "humans", "caused", "by", "melanocyte", "deficiencies", "in", "the", "inner", "ear", "forelock", "."], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0452138", "name": "C0452138#ent", "pos": [8, 9]}}
{"token": ["The", "ectopic", "and", "interstitial", "C0268314#ent", "<e1>", "as", "well", "as", "Sertoli", "cells", "negative", "for", "CK7", ",", "C3272788#ent", "<e2>", ",", "and", "CD10", "."], "h": {"id": "C0268314", "name": "C0268314#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3272788", "name": "C3272788#ent", "pos": [15, 16]}}
{"token": ["The", "standard", "for", "identifying", "skin", "DCs", "as", "C0268314#ent", "<e1>", "is", "expression", "of", "langerin", "(", "C3272788#ent", "<e2>", ")", ",", "a", "surface", "protein", "mediates", "Birbeck", "granule", "BG", ")", "formation", "upon", "internalization", "."], "h": {"id": "C0268314", "name": "C0268314#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3272788", "name": "C3272788#ent", "pos": [14, 15]}}
{"token": ["However", ",", "only", "approximately", "25", "%", "of", "C0268314#ent", "<e1>", "express", "the", "classical", "B-cell", "marker", "C3272788#ent", "<e2>", "."], "h": {"id": "C0268314", "name": "C0268314#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3272788", "name": "C3272788#ent", "pos": [14, 15]}}
{"token": ["3", "3-Isobutyl-l-methylxanthine", "(", "C0000096#ent", "<e1>", ")", "non-selectively", "inhibited", "all", "separated", "C0022173#ent", "<e2>", "activities", "."], "h": {"id": "C0000096", "name": "C0000096#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [10, 11]}}
{"token": ["Zaprinast", "and", "milrinone", "showed", "peak", "I", "peak", "III", "selectivity", ",", "and", "C0000096#ent", "<e1>", "non-selective", "activity", ",", "against", "both", "cardiac", "and", "vascular", "smooth", "muscle", "C0022173#ent", "<e2>", ",", "as", "expected", "for", "these", "reference", "inhibitors"], "h": {"id": "C0000096", "name": "C0000096#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [23, 24]}}
{"token": ["PS", "can", "be", "decarboxylated", "to", "PE", ",", "and", "C1418943#ent", "<e1>", "is", "synthesized", "from", "PE", "by", "C1418456#ent", "<e2>", "PEMT", ")", "."], "h": {"id": "C1418943", "name": "C1418943#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418456", "name": "C1418456#ent", "pos": [15, 16]}}
{"token": ["Both", "the", "pattern", "and", "the", "regulation", "of", "Bonzo", "expression", "closely", "paralleled", "that", "of", "CC", "family", "chemokine", "receptors", "CCR5", "or", "C1332701#ent", "<e1>", "and", "inversely", "correlated", "with", "C1332823#ent", "<e2>", "expression", "."], "h": {"id": "C1332701", "name": "C1332701#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [25, 26]}}
{"token": ["Localized", "tracheal", "pretreatment", "with", "the", "C3494348#ent", "<e1>", "DIDS", "or", "niflumic", "acid", "100", "microM", ")", "also", "significantly", "reduced", "C0010200#ent", "<e2>", ",", "whereas", "the", "GABAA", "receptor", "agonist", "muscimol", "potentiated", "acid-evoked", "responses", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [17, 18]}}
{"token": ["This", "study", "also", "suggests", "that", "C1423931#ent", "<e1>", "may", "provide", "a", "link", "between", "C0025517#ent", "<e2>", "hypoxia-induced", "angiogenesis", "."], "h": {"id": "C1423931", "name": "C1423931#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [12, 13]}}
{"token": ["In", "the", "first", "mechanism", ",", "retinol", "induced", "an", "influx", "in", "extracellular", "C2936886#ent", "<e1>", ",", "activation", "of", "C1259877#ent", "<e2>", "serine40", "phosphorylation", ",", "leading", "to", "tyrosine", "hydroxylase", "activation", "within", "15", "min", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [16, 17]}}
{"token": ["These", "results", "indicate", "that", "in", "addition", "to", "enhancing", "the", "actions", "of", "intracellular", "C2936886#ent", "<e1>", "in", "producing", "contraction", ",", "C1259877#ent", "<e2>", "also", "activate", "feedback", "mechanisms", "which", "limit", "cellular", "responses"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [18, 19]}}
{"token": ["Initial", "studies", "showed", "that", "non-selective", "C1513016#ent", "<e1>", "blocked", "the", "actions", "of", "deoxycholyltaurine", "(", "C1413933#ent", "<e2>", ")", ",", "thereby", "indicating", "a", "role", "for", "MMP-catalyzed", "release", "of", "an", "EGFR", "ligand", "."], "h": {"id": "C1513016", "name": "C1513016#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413933", "name": "C1413933#ent", "pos": [13, 14]}}
{"token": ["The", "three", "principal", "mitogen-activated", "protein", "kinase", "C1370600#ent", "<e1>", ")", "pathways", "are", "the", "extracellular", "signal-regulated", "protein", "kinase", "ERK", ")", ",", "the", "C0248813#ent", "<e2>", "JNK", ")", "cascade", "and", "the", "p38-MAPK", "cascade"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [20, 21]}}
{"token": ["Treatment", "of", "ES", "cell-derived", "embryoid", "bodies", "with", "RA", "resulted", "in", "a", "prolonged", "activation", "of", "the", "C1370600#ent", "<e1>", "pathway", ",", "but", "not", "the", "C0248813#ent", "<e2>", "p38", "mitogen-activated", "protein", "kinase", "phosphoinositide", "3-kinase", "pathways"], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [22, 23]}}
{"token": ["A", "cloned", "segment", "of", "DNA", "containing", "C1420886#ent", "<e1>", "resulted", "in", "specific", "binding", "of", "cells", "to", "synthetic", "C2826549#ent", "<e2>", "."], "h": {"id": "C1420886", "name": "C1420886#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2826549", "name": "C2826549#ent", "pos": [16, 17]}}
{"token": ["C1705281#ent", "<e1>", "is", "an", "C1823138#ent", "<e2>", "expressed", "on", "the", "apical", "surface", "of", "epithelial", "cells", "it", "acts", "as", "a", "signaling", "receptor"], "h": {"id": "C1705281", "name": "C1705281#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823138", "name": "C1823138#ent", "pos": [4, 5]}}
{"token": ["There", "was", "some", "independent", "association", "between", "C0497281#ent", "<e1>", "disabilities", ",", "use", "of", "physician", "services", "and", "use", "of", "C1336644#ent", "<e2>"], "h": {"id": "C0497281", "name": "C0497281#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336644", "name": "C1336644#ent", "pos": [17, 18]}}
{"token": ["After", "observing", "the", "need", "for", "high", "dose", "exogenous", "erythropoietin", "dosage", "in", "some", "patients", "on", "C1420403#ent", "<e1>", ",", "we", "hypothesized", "that", "C1420403#ent", "<e1>", "therapy", "may", "influence", "anemia", "by", "inducing", "a", "state", "of", "C1366564#ent", "<e1>"], "h": {"id": "C1420403", "name": "C1420403#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1366564", "name": "C1366564#ent", "pos": [31, 32]}}
{"token": ["These", "local", "symptoms", "accompanied", "by", "fever", ",", "fatigue", ",", "weight", "loss", "C0162296#ent", "<e1>", "and", "myalgia", ",", "similar", "to", "C0263445#ent", "<e2>"], "h": {"id": "C0162296", "name": "C0162296#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0263445", "name": "C0263445#ent", "pos": [18, 19]}}
{"token": ["Recently", "a", "candidate", "gene", "the", "C1420418#ent", "<e1>", "TDF", ")", "encoding", "a", "C1421587#ent", "<e2>", "ZFY", ")", "has", "been", "cloned", "from", "the", "human", "Y", "chromosome"], "h": {"id": "C1420418", "name": "C1420418#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421587", "name": "C1421587#ent", "pos": [11, 12]}}
{"token": ["A", "crossing", "over", "event", "in", "paternal", "meiosis", "proximal", "to", "the", "C1420418#ent", "<e1>", "locus", "but", "distal", "to", "the", "C1421587#ent", "<e2>", "ZFY", ")", "locus", ",", "presumably", "transferred", "to", "two", "loci", "to", "the", "X", "chromosome"], "h": {"id": "C1420418", "name": "C1420418#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421587", "name": "C1421587#ent", "pos": [17, 18]}}
{"token": ["In", "humans", ",", "the", "two", "human", "ubiquitin-CEP", "genes", "Uba80", "and", "C1421257#ent", "<e1>", ",", "which", "code", "for", "ubiquitin", "fused", "to", "C0382767#ent", "<e2>", "L40", ",", "respectively", "."], "h": {"id": "C1421257", "name": "C1421257#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0382767", "name": "C0382767#ent", "pos": [19, 20]}}
{"token": ["It", "has", "been", "reported", "that", "C0151449#ent", "<e1>", "various", "pulmonary", "involvement", "including", "lymphoid", "interstitial", "pneumonia", "C0034069#ent", "<e2>", "various", "pulmonary", "manifestation", "."], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [14, 15]}}
{"token": ["Consistent", "with", "inward", "orientation", "C1704941#ent", "<e1>", "from", "the", "C4284191#ent", "<e2>", "surface", ",", "the", "kappa-CDR3", "Arg97", "played", "no", "role", "in", "either", "dsDNA", "or", "ssDNA", "binding"], "h": {"id": "C1704941", "name": "C1704941#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4284191", "name": "C4284191#ent", "pos": [8, 9]}}
{"token": ["C2827368#ent", "<e1>", "was", "an", "aglycone", "of", "loganin", "and", "C3537374#ent", "<e2>", "was", "proved", "to", "be", "a", "new", "compound", "."], "h": {"id": "C2827368", "name": "C2827368#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537374", "name": "C3537374#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "show", "that", "fingers", "1", "5", "and", "9", "of", "C2827368#ent", "<e1>", "also", "interact", "with", "the", "N-finger", "of", "GATA-1", "and", "that", "C3537374#ent", "<e2>", "and", "U-shaped", "also", "contain", "multiple", "GATA-interacting", "fingers", "."], "h": {"id": "C2827368", "name": "C2827368#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3537374", "name": "C3537374#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "thyroid", "hormone", "controls", "ventricular", "myosin", "ATPase", "by", "controlling", "synthesis", "of", "a", "specific", "ventricular", "isoenzyme", ",", "whereas", "thyroid", "hormone", "not", "affect", "C0969681#ent", "<e1>", "possibly", "due", "to", "its", "inability", "to", "control", "C0969681#ent", "<e1>", "synthesis", "."], "h": {"id": "C0969681", "name": "C0969681#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0969681", "name": "C0969681#ent", "pos": [24, 25]}}
{"token": ["Small", "subanesthetic", "doses", "of", "C0700541#ent", "<e1>", "did", "inhibit", "C0270844#ent", "<e2>", "induced", "by", "a", "large", "dose", "of", "the", "GABA(A)", "receptor", "antagonist", "bicuculline", "8", "mg/kg", ")", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0270844", "name": "C0270844#ent", "pos": [8, 9]}}
{"token": ["This", "case", "suggests", "that", "the", "C0871189#ent", "<e1>", "occur", "following", "phenytoin", "treatment", "in", "some", "C0234533#ent", "<e2>", "patients", "may", "be", "the", "direct", "result", "of", "medication", ",", "unrelated", "to", "seizures", "."], "h": {"id": "C0871189", "name": "C0871189#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesized", "that", "RV", "ischemia", "induced", "during", "C0151814#ent", "<e1>", "proximal", "to", "the", "major", "right", "ventricular", "branches", "result", "in", "severe", "C1277187#ent", "<e2>", "detectable", "by", "the", "AVPD", "method", "."], "h": {"id": "C0151814", "name": "C0151814#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1277187", "name": "C1277187#ent", "pos": [19, 20]}}
{"token": ["Although", "this", "C0039082#ent", "<e1>", "was", "initially", "associated", "with", "DNA", "repair", "defect", "individuals", "with", "C2983123#ent", "<e2>", "develop", "neurological", "features", "such", "as", "microcephaly", "and", "hypomyelination", "that", "could", "be", "connected", "to", "transcriptional", "defects"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2983123", "name": "C2983123#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "the", "kinetics", "of", "ICAM-1", "expression", "on", "keratinocytes", "and", "correlated", "this", "with", "the", "numbers", "of", "lymphocytes", "expressing", "C1334146#ent", "<e1>", "in", "the", "dermis", "and", "epidermis", "of", "evolving", "allergic", "C0011616#ent", "<e2>", "reactions", "."], "h": {"id": "C1334146", "name": "C1334146#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0011616", "name": "C0011616#ent", "pos": [28, 29]}}
{"token": ["However", ",", "C0669372#ent", "<e1>", "was", "induced", "when", "A549", "cells", "treated", "simultaneously", "with", "BSO", "and", "C1414529#ent", "<e2>", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414529", "name": "C1414529#ent", "pos": [14, 15]}}
{"token": ["Expression", "of", "messenger", "RNA", "granulocyte-macrophage", "colony-stimulating", "factor", "C1334117#ent", "<e1>", "and", "the", "C1704824#ent", "<e2>", "undetectable", "in", "all", "of", "the", "tested", "cell", "lines", "while", "the", "various", "abundance", "of", "messenger", "RNA", "the", "epidermal", "growth", "factor", "receptor", "different", "in", "each", "cell", "line"], "h": {"id": "C1334117", "name": "C1334117#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704824", "name": "C1704824#ent", "pos": [11, 12]}}
{"token": ["C0036690#ent", "<e1>", "decreased", "the", "contractile", "responses", "the", "alpha", "1-adrenoceptor", "agonist", "phenylephrine", "and", "the", "C1259877#ent", "<e2>", "PKC", ")", "activator", "12-deoxyphorbol", "13-isobutyrate", "20-acetate", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}}
{"token": ["The", "potent", "GABAA", "agonists", "C0026818#ent", "<e1>", "and", "THIP", "are", "C0003286#ent", "<e2>", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [9, 10]}}
{"token": ["Mice", "with", "a", "C0085196#ent", "<e1>", "induced", "unilateral", "nigro-striatal", "lesion", "received", "C0011812#ent", "<e2>", "2.5", "-", "20", "mg/kg", ")", "over", "a", "3-month", "period", "by", "daily", "incorporation", "into", "the", "drinking", "water"], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011812", "name": "C0011812#ent", "pos": [10, 11]}}
{"token": ["One", "of", "the", "targets", "for", "this", "modulator", "effect", "is", "the", "C0812312#ent", "<e1>", "binding", "site", "within", "the", "c-jun", "and", "C0172956#ent", "<e2>"], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0172956", "name": "C0172956#ent", "pos": [18, 19]}}
{"token": ["These", "results", "collectively", "suggest", "that", "activation", "of", "C0172956#ent", "<e1>", "expression", "in", "dermal", "fibroblasts", "L-tryptophan", "is", "mediated", "through", "C0812312#ent", "<e2>", "binding", "elements", "in", "the", "C0172956#ent", "<e1>", "that", "are", "sufficient", "for", "gene", "response"], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0172956", "name": "C0172956#ent", "pos": [7, 8]}}
{"token": ["The", "NMR", "structure", "of", "pep-C7C1", "revealed", "a", "stabilizing", "type", "II", "beta-turn", "between", "C1455430#ent", "<e1>", "and", "Trp5", ",", "with", "C1707169#ent", "<e2>", "solvent", "exposed", "."], "h": {"id": "C1455430", "name": "C1455430#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1707169", "name": "C1707169#ent", "pos": [18, 19]}}
{"token": ["C4288963#ent", "<e1>", "be", "associated", "with", "significant", "C1839163#ent", "<e2>", "and", "appears", "to", "be", "a", "distinct", "clinical", "entity"], "h": {"id": "C4288963", "name": "C4288963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [6, 7]}}
{"token": ["Although", "both", "Sos1", "and", "C1705121#ent", "<e1>", "activate", "the", "Ras", "proteins", "Ha-Ras", ",", "C1705519#ent", "<e2>", ",", "and", "Ki-Ras", ",", "only", "C1705121#ent", "<e1>", "also", "activates", "the", "functionally", "distinct", "R-Ras", "GTPase", "."], "h": {"id": "C1705519", "name": "C1705519#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705121", "name": "C1705121#ent", "pos": [4, 5]}}
{"token": ["This", "study", "examined", "whether", "the", "manganese", "superoxide", "dismutase", "C1420307#ent", "<e1>", ")", "gene", "Ala-9Val", "single-nucleotide", "polymorphism", "SNP", ")", "is", "associated", "with", "C0543891#ent", "<e2>", "TD", ")", "and", "the", "severity", "of", "the", "abnormal", "involuntary", "movements", "Korean", "schizophrenic", "patients", "."], "h": {"id": "C1420307", "name": "C1420307#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0543891", "name": "C0543891#ent", "pos": [20, 21]}}
{"token": ["C0027030#ent", "<e1>", "from", "the", "botfly", "Dermatobia", "hominis", "is", "a", "common", "C0747256#ent", "<e2>", "the", "tropics", "of", "Central", "and", "South", "America", "and", "may", "present", "in", "the", "United", "States"], "h": {"id": "C0027030", "name": "C0027030#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [10, 11]}}
{"token": ["Bovine", "heart", "phosphotyrosyl", "phosphatase", "BHPTP", ")", "exemplifies", "this", "class", "and", "is", "highly", "C1334043#ent", "<e1>", "(", "94", "%", "sequence", "identity", "to", "an", "isoenzyme", "known", "as", "C1412131#ent", "<e2>", "is", "present", "throughout", "human", "tissues", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412131", "name": "C1412131#ent", "pos": [24, 25]}}
{"token": ["The", "inflammatory", "response", "C0024117#ent", "<e1>", "is", "essentially", "C0403397#ent", "<e2>", "so", "that", "alternative", "anti-inflammatory", "treatments", "needed", "."], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0403397", "name": "C0403397#ent", "pos": [7, 8]}}
{"token": ["Although", "a", "human", "disease", "not", "yet", "been", "genetically", "linked", "to", "a", "mutation", "in", "C1506962#ent", "<e1>", ",", "the", "prominent", "roles", "of", "C1335609#ent", "<e2>", "the", "maintenance", "of", "genome", "stability", "that", "RECQ1", "helicase", "likely", "to", "be", "important", "in", "vivo"], "h": {"id": "C1506962", "name": "C1506962#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335609", "name": "C1335609#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "the", "effects", "of", "Janus", "kinase", "JAK", ")", "inhibitors", ",", "C0381241#ent", "<e1>", "and", "WHI-P154", ",", "on", "C1968833#ent", "<e2>", "expression", "and", "NO", "production", "in", "J774", "murine", "macrophages", "stimulated", "with", "interferon-gamma", "(", "IFN-gamma", ")", "."], "h": {"id": "C0381241", "name": "C0381241#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [17, 18]}}
{"token": ["C0381241#ent", "<e1>", "also", "inhibited", "thrombin-induced", "transcription", "and", "expression", "of", "TNF-alpha", ",", "C1968833#ent", "<e2>", "and/or", "NO", "release", ",", "moreover", "rescued", "dopaminergic", "neurons"], "h": {"id": "C0381241", "name": "C0381241#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [11, 12]}}
{"token": ["Accordingly", ",", "we", "have", "termed", "the", "C0079429#ent", "<e1>", "and", "encoded", "protein", "Arc", "C1412501#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412501", "name": "C1412501#ent", "pos": [12, 13]}}
{"token": ["Patients", "with", "New", "York", "Heart", "Association", "class", "II", "C0018802#ent", "<e1>", "also", "receive", "a", "beta", "blocker", "metoprolol", ",", "carvedilol", "or", "C0053799#ent", "<e2>", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0053799", "name": "C0053799#ent", "pos": [19, 20]}}
{"token": ["Collagen", "(", "types", "I", "C3273406#ent", "<e1>", ",", "V", ",", "IX", "and", "XI", ")", "constituting", "C1305923#ent", "<e2>", "their", "polymers", "and", "cyanogen", "bromide-cleaved", "peptides", "of", "collagen", "type", "I", "type", "III", "investigated", "by", "means", "of", "capillary", "zone", "electrophoresis"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}}
{"token": ["Since", "vasoactive", "angiotensin", "II", "C3273406#ent", "<e1>", "releases", "these", "products", "from", "blood", "vessels", "this", "C1305923#ent", "<e2>", "was", "used", "in", "a", "porcine", "retinal", "circulation", "model", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [13, 14]}}
{"token": ["Interleukin", "2", "IL-2", ")", "production", "and", "proliferative", "responses", "of", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "stimulated", "with", "three", "concentrations", "of", "C0030779#ent", "<e1>", "were", "measured", "in", "75", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "and", "25", "normal", "controls"], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [28, 29]}}
{"token": ["Results", "indicated", "a", "dissociation", "between", "mitogenic", "response", "and", "secretion", "of", "mediators", "by", "PBMC", "under", "the", "influence", "of", "C0030779#ent", "<e1>", "in", "both", "normal", "controls", "in", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [26, 27]}}
{"token": ["We", "compared", "the", "activity", "of", "C0700480#ent", "<e1>", "at", "central", "H1", "sites", "with", "that", "of", "hydroxyzine", "and", "C0085173#ent", "<e2>", "."], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [16, 17]}}
{"token": ["The", "ID50s", "of", "ketotifen", ",", "C0700480#ent", "<e1>", ",", "betotastine", "and", "C0085173#ent", "<e2>", "for", "this", "model", "were", "more", "than", "0.01", "mg/kg", ",", "0.01", "mg/kg", ",", "0.03", "mg/kg", "and", "0.5", "mg/kg", ",", "respectively", "."], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [10, 11]}}
{"token": ["Intraperitoneally", "orally", "administered", "H1", "antagonists", "dimethindene", ",", "clemastine", ",", "cyproheptadine", ",", "astemizole", ",", "C0700480#ent", "<e1>", ",", "loratadine", "and", "C0085173#ent", "<e2>", ")", "inhibited", "the", "oedema", "to", "a", "statistically", "significant", ",", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [18, 19]}}
{"token": ["Dehalogenation", "of", "enflurane", ",", "which", "is", "the", "preferred", "pathway", ",", "is", "affected", "to", "the", "same", "extent", "as", "the", "cytochrome", "P-450-dependent", "hydroxylation", "C0018549#ent", "<e1>", "and", "the", "O-dealkylation", "of", "C0025688#ent", "<e2>", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0025688", "name": "C0025688#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "we", "demonstrate", "that", "C1366490#ent", "<e1>", "antagonizes", "TGFbeta-induced", "target", "gene", "expression", "apoptosis", "ex", "vivo", "primary", "C0669372#ent", "<e2>", ",", "establishing", "a", "new", "role", "for", "C1366490#ent", "<e1>", "in", "modulating", "single-transmembrane", "serine/threonine", "kinase", "signal", "transduction", "."], "h": {"id": "C1366490", "name": "C1366490#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}}
{"token": ["The", "plasma", "C1417807#ent", "<e1>", "concentrations", "in", "patients", "with", "C1414083#ent", "<e2>", "were", "35.5", "+", "/-", "3.3pg/ml", "(", "mean", "+", "/-", "SE", ")", "and", "higher", "than", "in", "normal", "subjects", "19.3", "+", "/-", "1.0pg/ml", ")", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "indicate", "that", "the", "synthesis", "of", "atrial", "natriuretic", "polypeptide", "C1417807#ent", "<e1>", ")", "is", "inhibited", "in", "C1414083#ent", "<e2>"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "indicate", "that", "the", "synthesis", "of", "C1417807#ent", "<e1>", "ANP", ")", "is", "inhibited", "in", "C1414083#ent", "<e2>"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [14, 15]}}
{"token": ["To", "study", "the", "regulation", "of", "cyclin-dependent", "kinase", "CDK", ")", "activity", "during", "mitotic", "exit", "mammalian", "cells", "we", "constructed", "murine", "cell", "lines", "C0907533#ent", "<e1>", "express", "a", "stabilized", "mutant", "of", "C1332694#ent", "<e2>", "cyclin", "A47", ")", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1332694", "name": "C1332694#ent", "pos": [27, 28]}}
{"token": ["Deregulated", "cyclin", "expression", "and", "CDK2", "activity", "was", "also", "observed", "in", "primary", "mouse", "osteoblasts", "overexpressing", "c-Fos", ",", "but", "not", "in", "fibroblasts", ",", "and", "c-Fos", "transgenic", "tumor-derived", "osteosarcoma", "cells", "C0907533#ent", "<e1>", "expressed", "high", "levels", "of", "C1332694#ent", "<e2>"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1332694", "name": "C1332694#ent", "pos": [33, 34]}}
{"token": ["A", "spray", "administration", "C0022322#ent", "<e1>", "was", "evaluated", "for", "the", "treatment", "of", "C0086227#ent", "<e2>", "mice", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0086227", "name": "C0086227#ent", "pos": [11, 12]}}
{"token": ["Cytoplasmic", "C1705323#ent", "<e1>", "immunoreactivity", "in", "C2697531#ent", "<e2>", "increased", "during", "culturing", "time"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2697531", "name": "C2697531#ent", "pos": [5, 6]}}
{"token": ["C1705323#ent", "<e1>", "was", "expressed", "in", "all", "C2697531#ent", "<e2>", "and", "in", "the", "non-tumorous", "liver", "tissue", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697531", "name": "C2697531#ent", "pos": [6, 7]}}
{"token": ["Immunoblotting", "also", "confirmed", "up-regulation", "of", "C1705323#ent", "<e1>", ",", "but", "not", "COX-1", ",", "in", "well-differentiated", "C2697531#ent", "<e2>", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697531", "name": "C2697531#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "the", "expression", "of", "C1705323#ent", "<e1>", "immunohistochemistry", "in", "53", "patients", "with", "C2697531#ent", "<e2>", "whose", "corresponding", "nontumor", "tissues", "hepatitis", "C", "virus-related", "chronic", "hepatitis", "n", "=", "21", ")", "and", "cirrhosis", "(", "n", "=", "32", ")", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697531", "name": "C2697531#ent", "pos": [12, 13]}}
{"token": ["TRAF6", ",", "in", "turn", ",", "enhances", "the", "kinase", "activity", "C1307053#ent", "<e1>", "leading", "to", "tyrosine", "phosphorylation", "C1332447#ent", "<e2>", "as", "c-Cbl", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [15, 16]}}
{"token": ["Genetic", "mapping", "the", "C0079429#ent", "<e1>", "to", "be", "very", "closely", "linked", "to", "C1822773#ent", "<e2>", ",", "one", "of", "the", "most", "proximal", "loci", "on", "MMU", "6", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1822773", "name": "C1822773#ent", "pos": [11, 12]}}
{"token": ["We", "also", "identified", "an", "amplicon", "at", "11p13", "that", "resulted", "in", "amplification", "and", "overexpression", "of", "CD44", ",", "a", "C0079429#ent", "<e1>", "involved", "in", "C1822773#ent", "<e2>", "autophosphorylation", "upon", "HGF", "stimulation", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1822773", "name": "C1822773#ent", "pos": [21, 22]}}
{"token": ["On", "the", "other", "hand", ",", "phosphoramidon", "(", "4", "nmol", ")", "/bestatin-induced", "antinociception", "was", "significantly", "antagonized", "by", "C0068389#ent", "<e1>", ",", "but", "not", "by", "C0068961#ent", "<e2>", "."], "h": {"id": "C0068389", "name": "C0068389#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0068961", "name": "C0068961#ent", "pos": [22, 23]}}
{"token": ["A", "14-week-old", "boy", "with", "undiagnosed", "C0007965#ent", "<e1>", "fever", "with", "a", "high", "temperature", "and", "C0018802#ent", "<e2>", "having", "received", "a", "scheduled", "vaccination", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["We", "had", "reported", "earlier", "the", "enhanced", "phosphorylation", "of", "a", "38-kilodalton", "protein", "(", "C1705633#ent", "<e1>", ")", "in", "rat", "liver", "plasma", "membrane", "by", "C0080058#ent", "<e2>"], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [21, 22]}}
{"token": ["He", "was", "diagnosed", "as", "having", "sternal", "osteomyelitis", "C0025064#ent", "<e1>", "and", "treated", "by", "sternal", "bone", "debridement", "irrigation", "with", "dilute", "povidone", "C0301299#ent", "<e2>", "no", "effects"], "h": {"id": "C0025064", "name": "C0025064#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0301299", "name": "C0301299#ent", "pos": [19, 20]}}
{"token": ["In", "this", "paper", ",", "we", "demonstrate", "that", "the", "motor", "response", "TIAs", "occurs", "in", "adjacent", "ganglia", "as", "well", "as", "in", "the", "C0085648#ent", "<e1>", "of", "origin", "for", "the", "C0007787#ent", "<e2>", "."], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [26, 27]}}
{"token": ["The", "localization", "of", "C0172870#ent", "<e1>", "in", "the", "C0005859#ent", "<e2>", "of", "the", "human", "jejunum", "may", "suggest", "that", "it", "specifically", "participates", "in", "the", "transfer", "of", "fructose", "across", "the", "basal", "membrane", "the", "enterocyte", "."], "h": {"id": "C0172870", "name": "C0172870#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005859", "name": "C0005859#ent", "pos": [7, 8]}}
{"token": ["Immunogold", "localization", "of", "C0172870#ent", "<e1>", "on", "ultrathin", "sections", "of", "human", "jejunum", "showed", "that", "C0172870#ent", "<e1>", "was", "present", "in", "both", "apical", "BBM", "and", "C0005859#ent", "<e1>", "."], "h": {"id": "C0172870", "name": "C0172870#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005859", "name": "C0005859#ent", "pos": [22, 23]}}
{"token": ["This", "new", "relation", "between", "p73", "and", "C1825553#ent", "<e1>", "may", "help", "to", "understand", "the", "different", "behavior", "of", "the", "C0812244#ent", "<e2>", "cell", "physiology", "in", "the", "responses", "of", "cancer", "cells", "chemotherapy", "."], "h": {"id": "C1825553", "name": "C1825553#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812244", "name": "C0812244#ent", "pos": [17, 18]}}
{"token": ["In", "the", "presence", "of", "C1825553#ent", "<e1>", ",", "C0812244#ent", "<e2>", "is", "more", "prone", "to", "cause", "caspase", "activation", "nuclei", "fragmentation", "C0812244#ent", "<e2>", "needs", "C1825553#ent", "<e1>", "to", "activate", "and", "enhance", "its", "apoptotic", "functions", "."], "h": {"id": "C1825553", "name": "C1825553#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812244", "name": "C0812244#ent", "pos": [7, 8]}}
{"token": ["In", "recent", "years", ",", "itraconazole", "pulse", "therapy", "for", "C0040261#ent", "<e1>", "has", "been", "developed", "[", "three", "1-week", "pulses", "with", "C0064113#ent", "<e2>", "400", "(", "2", "x", "200", ")", "mg", "daily", "every", "month", "]", "."], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [18, 19]}}
{"token": ["Both", "techniques", "used", "nitrous", "oxide", "oxygen", "with", "C0001981#ent", "<e1>", ",", "but", "in", "one", "the", "additional", "agent", "was", "C0018549#ent", "<e2>", "and", "in", "the", "other", "it", "was", "fentanyl", "."], "h": {"id": "C0001981", "name": "C0001981#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [17, 18]}}
{"token": ["Histograms", "displayed", "by", "the", "C3540811#ent", "<e1>", "indicate", "the", "cell", "size", "while", "dot", "displays", "by", "the", "C0030360#ent", "<e2>", "reflect", "the", "cell", "structure"], "h": {"id": "C3540811", "name": "C3540811#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030360", "name": "C0030360#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "the", "basal", "levels", "of", "the", "C1705526#ent", "<e1>", "and", "p21", "proteins", "significantly", "low", "in", "83", "%", "of", "C0795907#ent", "<e2>", "and", "modulated", "in", "the", "majority", "of", "TCFs", "compared", "with", "NBFs", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0795907", "name": "C0795907#ent", "pos": [19, 20]}}
{"token": ["The", "tumor", "responses", "initiation", "with", "HD", ",", "NTF", "and", "C1424602#ent", "<e1>", "were", "similar", "to", "that", "found", "with", "C1822725#ent", "<e2>", ",", "but", "lower", "than", "that", "with", "DMBA", "."], "h": {"id": "C1424602", "name": "C1424602#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1822725", "name": "C1822725#ent", "pos": [17, 18]}}
{"token": ["Experiments", "with", "yeast", "mutants", "lacking", "both", "the", "C3815867#ent", "<e1>", "well", "as", "the", "mitochondrial", "peroxiredoxin", "system", "an", "important", "role", "for", "C1425351#ent", "<e2>", "thioredoxin", "reductase", "and", "peroxiredoxin", "in", "the", "protection", "against", "oxidative", "stress"], "h": {"id": "C3815867", "name": "C3815867#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1425351", "name": "C1425351#ent", "pos": [19, 20]}}
{"token": ["Spinal", "muscular", "atrophy", "C0026847#ent", "<e1>", ")", "is", "the", "most", "common", "fatal", "C0027868#ent", "<e2>", "infancy", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "nitroglycerin-induced", "tolerance", "was", "unaffected", "by", "C0055729#ent", "<e1>", "(", "PDE3", "inhibitor", "and", "rolipram", "(", "C2936609#ent", "<e2>", "inhibitor", ")", "."], "h": {"id": "C0055729", "name": "C0055729#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2936609", "name": "C2936609#ent", "pos": [16, 17]}}
{"token": ["C0019342#ent", "<e1>", "a", "prevalent", "sexually", "transmitted", "C0042769#ent", "<e2>"], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [6, 7]}}
{"token": ["Affecting", "millions", "of", "Americans", "each", "year", ",", "C0019342#ent", "<e1>", "among", "the", "most", "common", "human", "C0042769#ent", "<e2>"], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [14, 15]}}
{"token": ["C0019342#ent", "<e1>", "a", "lifelong", "incurable", "C0042769#ent", "<e2>", "can", "have", "a", "significant", "psychological", "and", "emotional", "impact", "patients", "."], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}}
{"token": ["This", "translocation", "creates", "a", "fusion", "gene", "of", "nucleophosmin", "(", "C1704851#ent", "<e1>", ")", "and", "a", "novel", "C1335675#ent", "<e2>", "named", "anaplastic", "lymphoma", "kinase", "ALK", ")", "."], "h": {"id": "C1704851", "name": "C1704851#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335675", "name": "C1335675#ent", "pos": [15, 16]}}
{"token": ["Notably", ",", "a", "minimal", "common", "duplicated", "region", "at", "17q11.2", "approximately", "q12", ",", "corresponded", "to", "the", "mapping", "of", "C1704824#ent", "<e1>", "and", "STAT", "C1517488#ent", "<e2>"], "h": {"id": "C1704824", "name": "C1704824#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [21, 22]}}
{"token": ["Here", "we", "report", "that", "C0919507#ent", "<e1>", "and", "FGF10", ",", "members", "of", "the", "C0919505#ent", "<e2>", "are", "the", "best", "candidates", "for", "the", "direct", "inducer", "of", "the", "AER", "."], "h": {"id": "C0919507", "name": "C0919507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919505", "name": "C0919505#ent", "pos": [12, 13]}}
{"token": ["C1336578#ent", "<e1>", "BTHS", ")", "is", "a", "C0559758#ent", "<e2>", "individuals", "who", "carry", "mutations", "in", "tafazzin", ",", "a", "putative", "phospholipid", "acyltransferase"], "h": {"id": "C1336578", "name": "C1336578#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0559758", "name": "C0559758#ent", "pos": [6, 7]}}
{"token": ["C1336578#ent", "<e1>", "BTHS", ")", "is", "a", "serious", "X-linked", ",", "metabolic", ",", "C0559758#ent", "<e2>", "by", "cardiomyopathy", ",", "neutropenia", ",", "myopathy", ",", "and", "growth", "delay"], "h": {"id": "C1336578", "name": "C1336578#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0559758", "name": "C0559758#ent", "pos": [11, 12]}}
{"token": ["Barth", "syndrome", "C1336578#ent", "<e1>", ")", "is", "a", "C0559758#ent", "<e2>", "individuals", "who", "carry", "mutations", "in", "tafazzin", ",", "a", "putative", "phospholipid", "acyltransferase"], "h": {"id": "C1336578", "name": "C1336578#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0559758", "name": "C0559758#ent", "pos": [7, 8]}}
{"token": ["We", "investigated", "the", "effects", "of", "angiotensin-converting", "enzyme", "inhibitor", "an", "C1449680#ent", "<e1>", "cardiac", "hypertrophy", "rats", "with", "C0020545#ent", "<e2>"], "h": {"id": "C1449680", "name": "C1449680#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020545", "name": "C0020545#ent", "pos": [15, 16]}}
{"token": ["Haemolytic", "disease", "the", "newborn", "is", "mostly", "caused", "by", "Rh", "antibody", "anti-D", "C0853694#ent", "<e1>", "and", "antibodies", "of", "the", "ABO", "system", "anti-A", "anti-B", "(", "C0014761#ent", "<e2>", "."], "h": {"id": "C0853694", "name": "C0853694#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0014761", "name": "C0014761#ent", "pos": [22, 23]}}
{"token": ["We", "also", "review", "and", "compare", "similar", "disorders", ",", "such", "as", "C0265253#ent", "<e1>", ",", "Weissenbacher-Zweim\u00fcller", ",", "and", "Wagner", "syndromes", "and", "conclude", "that", "C0265235#ent", "<e2>", "a", "distinct", "entity", "."], "h": {"id": "C0265253", "name": "C0265253#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0265235", "name": "C0265235#ent", "pos": [21, 22]}}
{"token": ["He", "was", "iatrogenously", "immunocompromised", "because", "of", "a", "\"", "self-medication", "\"", "with", "32", "mg", "per", "day", "of", "C0032950#ent", "<e1>", "30", "months", "for", "C0003868#ent", "<e2>"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [16, 17]}, "relation": "may_prevent", "t": {"id": "C0003868", "name": "C0003868#ent", "pos": [21, 22]}}
{"token": ["To", "investigate", "the", "therapeutic", "effects", "Angelica", "sinensis", "C0357080#ent", "<e1>", "APIC", ")", "on", "rats", "with", "C0162316#ent", "<e2>", "IDA", ")", "."], "h": {"id": "C0357080", "name": "C0357080#ent", "pos": [7, 8]}, "relation": "may_prevent", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [14, 15]}}
{"token": ["To", "our", "knowledge", ",", "this", "is", "the", "first", "report", "of", "a", "patient", "with", "both", "MEN1", "and", "C0598034#ent", "<e1>", "mutations", "and", "with", "a", "personal", "history", "C0020502#ent", "<e2>", "and", "pancreatic", "neuroendocrine", "tumors"], "h": {"id": "C0598034", "name": "C0598034#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020502", "name": "C0020502#ent", "pos": [24, 25]}}
{"token": ["Expression", "of", "the", "MRF4", "cDNA", "leads", "to", "expression", "of", "the", "endogenous", "MyoD1", "and", "C1417575#ent", "<e1>", "C0017337#ent", "<e2>", ",", "although", "C3H10T1/2", "cells", "expressing", "MyoD1", "or", "C1417575#ent", "<e1>", "cDNAs", "do", "not", "express", "MRF4", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417575", "name": "C1417575#ent", "pos": [13, 14]}}
{"token": ["Pbx", "homeodomain", "proteins", "promoters", "of", "a", "subset", "of", "Myod", "target", "C0017337#ent", "<e1>", ",", "including", "myogenin", "(", "C1417575#ent", "<e2>", ")", ";", "thus", ",", "Pbx", "proteins", "might", "modulate", "the", "program", "of", "myogenesis", "driven", "by", "Myod", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417575", "name": "C1417575#ent", "pos": [16, 17]}}
{"token": ["These", "data", "show", "that", "allicin", "has", "significant", "C0042402#ent", "<e1>", "the", "pulmonary", "vascular", "bed", "the", "rat", ",", "whereas", "allyl", "mercaptan", "C0057695#ent", "<e2>", "no", "significant", "changes", "in", "pulmonary", "arterial", "perfusion", "pressure"], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0057695", "name": "C0057695#ent", "pos": [19, 20]}}
{"token": ["Severe", "congenital", "neutropenia", "SCN", ")", ",", "also", "known", "as", "Kostmann", "syndrome", "C1853118#ent", "<e1>", ",", "OMIM", "610738", ")", ",", "includes", "a", "variety", "of", "C0037274#ent", "<e2>", "by", "different", "genetic", "abnormalities"], "h": {"id": "C1853118", "name": "C1853118#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [22, 23]}}
{"token": ["The", "C1423498#ent", "<e1>", "cell-granule", "cell", "currents", "show", "immature", "kinetics", "associated", "with", "reduced", "C1414910#ent", "<e2>", "expression", "in", "granule", "cells"], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414910", "name": "C1414910#ent", "pos": [12, 13]}}
{"token": ["Progressive", "walking", "difficulties", "and", "bladder", "dysfunction", "be", "attributed", "to", "C0002395#ent", "<e1>", "atlanto-axial", "subluxation", "people", "with", "C0013080#ent", "<e2>", "DS", ")", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0013080", "name": "C0013080#ent", "pos": [15, 16]}}
{"token": ["Adenoviral", "expression", "of", "constitutively", "active", "AKT", "and", "lithium", "chloride-mediated", "inhibition", "of", "C1423043#ent", "<e1>", "reduce", "the", "potentiated", "programmed", "cell", "death", "by", "C1335278#ent", "<e2>", "."], "h": {"id": "C1423043", "name": "C1423043#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335278", "name": "C1335278#ent", "pos": [20, 21]}}
{"token": ["Abnormalities", "of", "small", "bowel", "transit", "be", "demonstrated", "in", "patients", "with", "the", "irritable", "bowel", "syndrome", "and", "patients", "with", "C0021847#ent", "<e1>", "to", "either", "a", "C0042781#ent", "<e2>", "neuropathy", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0042781", "name": "C0042781#ent", "pos": [22, 23]}}
{"token": ["These", "cases", "illustrate", "yet", "another", "cause", "of", "C0021847#ent", "<e1>", "is", "histologically", "distinct", "from", "C0042781#ent", "<e2>", "neuropathies", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042781", "name": "C0042781#ent", "pos": [13, 14]}}
{"token": ["C1333245#ent", "<e1>", ",", "a", "member", "of", "the", "C3813548#ent", "<e2>", "family", "of", "proteins", ",", "plays", "roles", "in", "biological", "processes", "as", "phagocytosis", "and", "motility", "through", "its", "association", "with", "the", "signalling", "adaptor", "protein", "Crk", "."], "h": {"id": "C1333245", "name": "C1333245#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3813548", "name": "C3813548#ent", "pos": [7, 8]}}
{"token": ["A", "single", "dose", "the", "dopamine", "agonists", "L-dopa", "bromocriptine", "or", "C0237406#ent", "<e1>", "produced", "a", "protective", "effect", "significantly", "shortening", "of", "the", "length", "of", "C0038358#ent", "<e2>"], "h": {"id": "C0237406", "name": "C0237406#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [21, 22]}}
{"token": ["The", "influence", "of", "longterm", "increase", "(", "C0237406#ent", "<e1>", "in", "a", "high", "dose", "and", "decrease", "(", "haloperidol", ",", "C0237406#ent", "<e1>", "in", "a", "low", "dose", "on", "suprarenals", "weight", "and", "C0038358#ent", "<e1>", "animals", "exposed", "by", "aversive", "stimulation", "also", "studied", "."], "h": {"id": "C0237406", "name": "C0237406#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [27, 28]}}
{"token": ["In", "some", "cases", ",", "long-term", "administration", "of", "CPH", "to", "children", "with", "C4025821#ent", "<e1>", "is", "associated", "with", "decreased", "F", "response", "C0858734#ent", "<e2>", "this", "may", "represent", "decreased", "adrenocortical", "reserve", "these", "patients", "."], "h": {"id": "C4025821", "name": "C4025821#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0858734", "name": "C0858734#ent", "pos": [19, 20]}}
{"token": ["The", "C1848862#ent", "<e1>", "is", "characterized", "by", "subacute", "onset", "leg", "weakness", "numbness", "progressing", "to", "C0037771#ent", "<e2>", "or", "paraplegia", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037771", "name": "C0037771#ent", "pos": [13, 14]}}
{"token": ["Three", "siblings", "in", "a", "Jordanian", "family", "presented", "with", "a", "distinctive", "C1848862#ent", "<e1>", "consisting", "of", "disordered", "skin", "hair", "pigmentation", "progressive", "C0037771#ent", "<e2>", "peripheral", "neuropathy"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037771", "name": "C0037771#ent", "pos": [19, 20]}}
{"token": ["We", "have", "demonstrated", "that", "IFN-gamma", "and", "C0812246#ent", "<e1>", "synergistically", "induce", "HLA-DRalpha", "and", "C1824738#ent", "<e2>", "mRNAs", ",", "but", "prolonged", "incubation", "resulted", "in", "the", "inhibition", "of", "C1824738#ent", "<e2>", "mRNA", "accumulation", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1824738", "name": "C1824738#ent", "pos": [12, 13]}}
{"token": ["Kindler", "syndrome", "KS", ")", "is", "a", "rare", "inherited", "C0037274#ent", "<e1>", "blistering", "and", "C0392777#ent", "<e2>", "as", "its", "main", "clinical", "features", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0392777", "name": "C0392777#ent", "pos": [12, 13]}}
{"token": ["The", "control", "of", "C0036323#ent", "<e1>", "has", "been", "a", "challenging", "C1416596#ent", "<e2>", "for", "most", "endemic", "countries"], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [9, 10]}}
{"token": ["Successfully", "controlling", "C0036323#ent", "<e1>", "in", "China", "is", "still", "a", "long-term", "C1416596#ent", "<e2>", "but", "will", "be", "achieved", "without", "doubt", "along", "with", "the", "economic", "development", "the", "promotion", "of", "living", "and", "cultural", "standard", "people", "."], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [10, 11]}}
{"token": ["We", "have", "determined", "the", "MHC", "class", "II", "DRB1", ",", "DQA1", ",", "DQB1", ",", "DPB1", ")", "and", "class", "III", "TNF", ",", "HSP70", ",", "C4283853#ent", "<e1>", ",", "21OH", ")", "gene", "polymorphism", "in", "patients", "with", "C2103602#ent", "<e2>"], "h": {"id": "C4283853", "name": "C4283853#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2103602", "name": "C2103602#ent", "pos": [32, 33]}}
{"token": ["Systematic", "C4283882#ent", "<e1>", "studies", "of", "the", "different", "regioisomers", "and", "C1334043#ent", "<e2>", "of", "the", "spiro(indane-1,4-piperidine", ")", "moiety", "in", "the", "growth", "hormone", "secretagogue", "L-162,752", "presented", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["Cloning", "and", "molecular", "characterization", "the", "C4283882#ent", "<e1>", "locus", "revealed", "that", "it", "potentially", "encodes", "a", "C1334043#ent", "<e2>", "FtsH", ",", "an", "ATP-dependent", "metalloprotease", "belongs", "to", "a", "large", "protein", "family", "in", "various", "cellular", "functions"], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}}
{"token": ["However", ",", "some", "patients", "with", "the", "classical", "C0079588#ent", "<e1>", "phenotype", "and", "complete", "C0037556#ent", "<e2>", "deficiency", "do", "not", "show", "any", "detectable", "deletions", "by", "Southern", "blot", "analysis", "full-length", "C0037556#ent", "<e2>", "cDNA", "as", "a", "probe", "."], "h": {"id": "C0079588", "name": "C0079588#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037556", "name": "C0037556#ent", "pos": [12, 13]}}
{"token": ["X-linked", "ichthyosis", "C0079588#ent", "<e1>", ")", "is", "an", "inborn", "error", "metabolism", "caused", "by", "steroid", "sulfatase", "C0037556#ent", "<e2>", ")", "deficiency", "."], "h": {"id": "C0079588", "name": "C0079588#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037556", "name": "C0037556#ent", "pos": [14, 15]}}
{"token": ["The", "prostatic", "LHRH-DA", "is", "also", "inhibited", ",", "in", "a", "dose", "dependent", "manner", ",", "by", "bacitracin", ",", "C0033607#ent", "<e1>", "diisopropylfluorophosphate", "and", "C0031493#ent", "<e2>", ")", ",", "the", "metal", "chelating", "agent", "EDTA", "HgCl2", ",", "and", "dithiothreitol", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031493", "name": "C0031493#ent", "pos": [20, 21]}}
{"token": ["C0033607#ent", "<e1>", "as", "aprotinin", ",", "soybean", "trypsin", "inhibitor", "C0031493#ent", "<e2>", "inhibited", "peptidase", "activity"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031493", "name": "C0031493#ent", "pos": [8, 9]}}
{"token": ["C3542457#ent", "<e1>", "and", "fatty", "acid", "diols", "from", "arachidonate", "by", "the", "action", "of", "C0010762#ent", "<e2>", "in", "human", "urine", "and", "have", "biological", "activities"], "h": {"id": "C3542457", "name": "C3542457#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [12, 13]}}
{"token": ["Vital", "prognosis", "on", "either", "C0162557#ent", "<e1>", "hematological", "or", "C0032965#ent", "<e2>", "or", "amyloidosis", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032965", "name": "C0032965#ent", "pos": [8, 9]}}
{"token": ["Further", "studies", "including", "other", "inhibitors", "of", "ACE", "or", "of", "other", "C0030940#ent", "<e1>", "with", "immune", ",", "inflammatory", "or", "C1801950#ent", "<e2>", "role", ",", "may", "identify", "potentially", "valuable", "immunopharmacologic", "agents"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1801950", "name": "C1801950#ent", "pos": [17, 18]}}
{"token": ["These", "results", "demonstrate", "that", "ROS", "downregulate", "the", "expression", "of", "C1413138#ent", "<e1>", "in", "mesangial", "cells", "PI", "3", "signaling", "via", "C1333572#ent", "<e2>", "as", "a", "target", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333572", "name": "C1333572#ent", "pos": [18, 19]}}
{"token": ["Several", "C0596537#ent", "<e1>", "not", "capable", "of", "causing", "C0235025#ent", "<e2>", "themselves", ",", "exacerbate", "organophosphate-induced", "delayed", "polyneuropathy", "(", "OPIDP", ")", "and", "other", "axonopathies", "."], "h": {"id": "C0596537", "name": "C0596537#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "C1705783#ent", "<e1>", "gene", "transfer", "inducible", "nitric", "oxide", "synthase", "p53", "but", "decreased", "C1366837#ent", "<e2>", "and", "Bcl-2", "protein", "in", "balloon-injured", "rat", "aorta", "."], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [13, 14]}}
{"token": ["Twenty-six", "out-patients", "with", "C0003873#ent", "<e1>", "RA", ")", "were", "randomly", "allocated", "to", "treatment", "with", "C0036078#ent", "<e2>", "(", "SASP", ")", "or", "D-penicillamine", "(", "DPA", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [13, 14]}}
{"token": ["At", "onset", "of", "C0003873#ent", "<e1>", "36-year-old", "woman", "was", "started", "on", "a", "course", "of", "C0036078#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [13, 14]}}
{"token": ["Seventy", "nine", "patients", "with", "C0003873#ent", "<e1>", "active", "disease", "prospectively", "treated", "with", "sodium", "aurothiomalate", "auranofin", ",", "or", "C0036078#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [16, 17]}}
{"token": ["A", "surprisingly", "high", "number", "of", "antibodies", ",", "13", "on", "C1417030#ent", "<e1>", "and", "9", "on", "C1425825#ent", "<e2>", ",", "did", "not", "bind", "to", "the", "cell", "surface", "immunoglobulin"], "h": {"id": "C1417030", "name": "C1417030#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425825", "name": "C1425825#ent", "pos": [14, 15]}}
{"token": ["C2699992#ent", "<e1>", "has", "ATPase", "activity", "is", "stimulated", "by", "C0021345#ent", "<e2>", ",", "and", "patient", "mutations", "the", "ATPase", "domain", "attenuate", "this", "activity", "."], "h": {"id": "C2699992", "name": "C2699992#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [8, 9]}}
{"token": ["But", "unlike", "the", "previously", "described", "SWI/SNF", "or", "NURD", "complexes", ",", "the", "C2699992#ent", "<e1>", "complex", "does", "not", "randomize", "DNA", "phasing", "of", "the", "C0021345#ent", "<e2>", ",", "suggesting", "that", "it", "may", "remodel", "chromatin", "differently", "."], "h": {"id": "C2699992", "name": "C2699992#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [21, 22]}}
{"token": ["Indeed", ",", "different", "clinical", "responses", "C3540778#ent", "<e1>", "have", "been", "observed", "among", "patients", "with", "C0156147#ent", "<e2>", "suggesting", "different", "degrees", "of", "corticosensitivity", "in", "these", "subjects", "."], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [13, 14]}}
{"token": ["Toxic", "megacolon", "while", "the", "patient", "was", "treated", "with", "fluoroquinolone", "antibiotic", "and", "C3540778#ent", "<e1>", ",", "which", "were", "given", "for", "endoscopically", "suspected", "C0156147#ent", "<e2>"], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [20, 21]}}
{"token": ["Patients", "were", "randomised", "to", "receive", "either", "C0072857#ent", "<e1>", "or", "nifedipine", "retard", "and", "the", "dose", "escalated", "to", "C0020538#ent", "<e2>"], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "C1412056#ent", "<e1>", "infection", "of", "permissive", "cells", ",", "known", "to", "express", "both", "C0919509#ent", "<e2>", "and", "the", "epidermal", "growth", "factor", "receptor", "is", "abrogated", "by", "treatment", "of", "cells", "with", "basic", "fibroblast", "growth", "factor", "but", "not", "with", "epidermal", "growth", "factor"], "h": {"id": "C1412056", "name": "C1412056#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "describe", "the", "interaction", "of", "Na(+)/H(+)", "exchanger", "regulatory", "factor", "1", "NHERF1", ")", "with", "C3538744#ent", "<e1>", "via", "the", "last", "four", "C3539947#ent", "<e2>", "(1322)ETAL(1325", ")", ")", "of", "the", "transporter", "."], "h": {"id": "C3538744", "name": "C3538744#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [21, 22]}}
{"token": ["A", "pool", "of", "antibodies", "against", "C0021400#ent", "<e1>", "another", "against", "influenza", "B", "HA1", "-", "71", "and", "C1422252#ent", "<e2>", "-", "76", "monoclonal", "antibodies", "used", "for", "the", "subtyping", "in", "H1", "and", "H3", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422252", "name": "C1422252#ent", "pos": [15, 16]}}
{"token": ["C1335641#ent", "<e1>", "has", "been", "identified", "as", "the", "first", "C0017337#ent", "<e2>", "associated", "with", "Diamond-Blackfan", "anemia", "DBA", ")", ",", "a", "rare", "congenital", "hypoplastic", "anemia", "includes", "variable", "physical", "malformations"], "h": {"id": "C1335641", "name": "C1335641#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["C1335641#ent", "<e1>", "is", "the", "only", "C0017337#ent", "<e2>", "yet", "to", "have", "been", "associated", "with", "DBA", ",", "but", "its", "relevance", "to", "erythroid", "differentiation", "is", "unclear", "."], "h": {"id": "C1335641", "name": "C1335641#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}}
{"token": ["In", "2003", ",", "a", "previously", "unknown", "coronavirus", "was", "identified", "to", "be", "the", "etiological", "agent", "a", "global", "outbreak", "of", "a", "form", "of", "life-threatening", "C0032285#ent", "<e1>", "called", "severe", "C1175175#ent", "<e2>", "SARS", ")", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C1175175", "name": "C1175175#ent", "pos": [26, 27]}}
{"token": ["It", "is", "used", "to", "treat", "influenza", ",", "epidemic", "cerebrospinal", "meningitis", "encephalitis", "B", "C0032285#ent", "<e1>", "mumps", ",", "and", "severe", "C1175175#ent", "<e2>", "SARS", ")", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C1175175", "name": "C1175175#ent", "pos": [18, 19]}}
{"token": ["Immunoreactive", "C1707839#ent", "<e1>", "was", "detected", "in", "cyst", "epithelia", "mesangial", "cells", "vascular", "smooth", "muscle", "cells", "continuing", "ET1", "synthesis", "the", "C3887499#ent", "<e2>"], "h": {"id": "C1707839", "name": "C1707839#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3887499", "name": "C3887499#ent", "pos": [18, 19]}}
{"token": ["These", "results", "suggest", "that", "C3640214#ent", "<e1>", "is", "regulated", "by", "Cdk1", "and", "C1335227#ent", "<e2>", "in", "concert", "."], "h": {"id": "C3640214", "name": "C3640214#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [11, 12]}}
{"token": ["The", "incidence", "of", "three", "C0036916#ent", "<e1>", "namely", "Trichomonas", "vaginalis", "Herpes", "simplex", "and", "C0009663#ent", "<e2>", "revealed", "highly", "significant", ",", "especially", "in", "women", "whose", "cervix", "bled", "to", "the", "touch", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0009663", "name": "C0009663#ent", "pos": [12, 13]}}
{"token": ["lambdafus3", "carries", "C1417679#ent", "<e1>", "for", "protein", "elongation", "EF-Tu", "and", "EF-G", ",", "and", "C0754910#ent", "<e2>", "in", "addition", "to", "C1417679#ent", "<e1>", "for", "approximately", "27", "r", "proteins", "."], "h": {"id": "C0754910", "name": "C0754910#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}}
{"token": ["The", "effects", "of", "intrathecally", "administered", "C2936550#ent", "<e1>", "N6-(L-2-phenylisopropyl)-adenosine", "(", "LPIA", ")", "or", "an", "C2936570#ent", "<e2>", "5'-(N-ethyl", "carboxamido)-adenosine", "(", "NECA", ")", ",", "on", "this", "touch-evoked", "hyperesthesia", "were", "examined", "."], "h": {"id": "C2936550", "name": "C2936550#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936570", "name": "C2936570#ent", "pos": [13, 14]}}
{"token": ["The", "data", "are", "discussed", "in", "terms", "of", "the", "C4048284#ent", "<e1>", "anxiolytic", "or", "anti-conflict", "properties", "of", "these", "C0030956#ent", "<e2>", "."], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}}
{"token": ["It", "is", "not", "known", "whether", "C4048284#ent", "<e1>", "affect", "expression", "of", "proopiomelanocortin", ",", "precursor", "protein", "adrenocorticotropic", "hormone", "related", "C0030956#ent", "<e2>", "."], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}}
{"token": ["C1420472#ent", "<e1>", "is", "highly", "conserved", "between", "mouse", "and", "human", ",", "whereas", "C3539741#ent", "<e2>", "is", "somewhat", "less", "conserved", "(", "96.5", "and", "88", "%", "identity", "in", "the", "kinase", "domains", "respectively", ")", "."], "h": {"id": "C1420472", "name": "C1420472#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539741", "name": "C3539741#ent", "pos": [11, 12]}}
{"token": ["A", "positive", "antibody", "titer", "for", "C0085315#ent", "<e1>", ",", "which", "can", "occur", "parallel", "with", "the", "typical", "C0025007#ent", "<e2>", "or", "SSPE", "virus", "titer", ",", "occasionally", "causes", "the", "misdiagnosis", "of", "toxoplasmosis", "acquisita"], "h": {"id": "C0085315", "name": "C0085315#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025007", "name": "C0025007#ent", "pos": [15, 16]}}
{"token": ["When", "concentration", "of", "antibody", "in", "the", "CSF", "is", "higher", "for", "C0085315#ent", "<e1>", "than", "for", "C0025007#ent", "<e2>", ",", "the", "existence", "of", "a", "congenital", "infection", "C0085315#ent", "<e1>", "can", "be", "suggested", "."], "h": {"id": "C0085315", "name": "C0085315#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025007", "name": "C0025007#ent", "pos": [14, 15]}}
{"token": ["Current", "models", "propose", "that", "the", "functions", "of", "C2346452#ent", "<e1>", "should", "be", "disrupted", "by", "a", "small", "C0597298#ent", "<e2>", "that", "retains", "the", "dimerization", "domain", "lacks", "the", "DNA-binding", "domain"], "h": {"id": "C2346452", "name": "C2346452#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [15, 16]}}
{"token": ["The", "urinary", "activities", "the", "C4048196#ent", "<e1>", "alpha-fucosidase", ",", "alpha-mannosidase", "(", "pH", "4.5", ")", "and", "C0005220#ent", "<e2>", "increased", "in", "normal", "pregnancy"], "h": {"id": "C4048196", "name": "C4048196#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "safety", "and", "efficacy", "of", "rituximab", "(", "C0073081#ent", "<e1>", ")", "for", "systemic", "symptoms", "patients", "with", "C0151449#ent", "<e2>", "pSS", ")", ",", "and", "changes", "in", "B", "cell", "biomarkers", "."], "h": {"id": "C0073081", "name": "C0073081#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "treatment", "with", "mixtures", "of", "antisense", "oligonucleotides", "cdc2", "and", "C0108855#ent", "<e1>", "resulted", "in", "down-regulation", "of", "both", "cdc2", "and", "C1533646#ent", "<e2>", "as", "well", "as", "significant", "neurite", "outgrowth", "up-regulation", "of", "microtubule-associated", "protein", "2", "expression", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1533646", "name": "C1533646#ent", "pos": [20, 21]}}
{"token": ["Despite", "the", "lack", "of", "an", "increase", "in", "the", "expression", "of", "C0108855#ent", "<e1>", ",", "a", "small", "pool", "of", "pre-existing", "C1533646#ent", "<e2>", "detected", "in", "resting", "T", "cells", "be", "activated", "upon", "induction", "of", "competence", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1533646", "name": "C1533646#ent", "pos": [18, 19]}}
{"token": ["C0027302#ent", "<e1>", "is", "a", "nonselective", "C0001644#ent", "<e2>", "does", "not", "affect", "T3", "production", "."], "h": {"id": "C0027302", "name": "C0027302#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [5, 6]}}
{"token": ["The", "efficacy", "and", "safety", "of", "C0027302#ent", "<e1>", "and", "atenolol", ",", "2", "new", "C0001644#ent", "<e2>", "were", "evaluated", "in", "patients", "with", "recurrent", "supraventricular", "tachycardia", "SVT", ")", "."], "h": {"id": "C0027302", "name": "C0027302#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [12, 13]}}
{"token": ["In", "vitro", "C0031727#ent", "<e1>", "activities", "of", "C1138418#ent", "<e2>", "were", "stimulated", "with", "a", "slower", "kinetics", "by", "a", "variety", "of", "agonists", "to", "p70S6K"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1138418", "name": "C1138418#ent", "pos": [6, 7]}}
{"token": ["Human", "dermal", "papilla", "cells", "C0068006#ent", "<e1>", ")", "express", "mRNA", "for", "the", "key", "C3540790#ent", "<e2>", "for", "de", "novo", "and", "regulation", "of", "the", "pterin", "(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin", "6BH4", ")", "."], "h": {"id": "C0068006", "name": "C0068006#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}}
{"token": ["Unless", "the", "condition", "is", "treated", "by", "bone", "marrow", "transplantation", "the", "prognosis", "of", "C1421478#ent", "<e1>", "grave", ",", "and", "premature", "death", "by", "C0036690#ent", "<e2>", ",", "hemorrhage", ",", "or", "lymphoreticular", "malignancy", "is", "common", "."], "h": {"id": "C1421478", "name": "C1421478#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [20, 21]}}
{"token": ["Lapachol", "is", "a", "naphtoquinone", "with", "therapeutic", "potential", "against", "C0014378#ent", "<e1>", ",", "Chagas", "disease", "is", "also", "used", "as", "an", "antimalarial", "and", "C0003209#ent", "<e2>"], "h": {"id": "C0014378", "name": "C0014378#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003209", "name": "C0003209#ent", "pos": [20, 21]}}
{"token": ["Plasma", "adrenocorticotropin", ",", "corticosterone", ",", "C3887648#ent", "<e1>", "and", "epinephrine", "levels", "were", "similar", "in", "the", "C4284124#ent", "<e2>", "and", "WT", "genotypes", "resting", "conditions"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [14, 15]}}
{"token": ["Heart", "rate", "motor", "activity", "increased", "similarly", ",", "and", "there", "also", "were", "no", "differences", "in", "the", "increases", "in", "plasma", "renin", "activity", "or", "plasma", "C3887648#ent", "<e1>", "concentration", "between", "WT", "and", "C4284124#ent", "<e2>"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [28, 29]}}
{"token": ["Baseline", "epinephrine", "and", "glucagon", "were", "similar", ",", "and", "C3887648#ent", "<e1>", "was", "elevated", ",", "in", "CRH", "C4284124#ent", "<e2>", "vs.", "WT", "mice"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [15, 16]}}
{"token": ["Congenital", "adrenal", "hyperplasia", "results", "from", "an", "adrenal", "enzyme", "deficiency", "that", "causes", "an", "underproduction", "of", "glucocorticoids", "and", "sometimes", "C3541395#ent", "<e1>", "and", "a", "resultant", "C0221406#ent", "<e2>", "of", "androgens", ",", "until", "treatment", "with", "replacement", "glucocorticoids", "instituted", "."], "h": {"id": "C3541395", "name": "C3541395#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [22, 23]}}
{"token": ["C1420192#ent", "<e1>", "co-stimulatory", "activity", "mediated", "by", "either", "mAb", "80A10", "or", "C4084711#ent", "<e2>", ",", "a", "well-characterized", "CD98-specific", "mAb", ",", "is", "blocked", "in", "the", "presence", "of", "the", "soluble", "beta1", "integrin", "18D3", "."], "h": {"id": "C1420192", "name": "C1420192#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4084711", "name": "C4084711#ent", "pos": [10, 11]}}
{"token": ["We", "sought", "to", "determine", "if", "PGI(2)", "concentrations", "or", "polymorphisms", "of", "the", "C1419071#ent", "<e1>", "with", "severity", "of", "RSV", "lower", "C0035243#ent", "<e2>", "LRTI", ")", "in", "human", "infants", "."], "h": {"id": "C1419071", "name": "C1419071#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [18, 19]}}
{"token": ["Preoptic", "infusions", "epinephrine", "and", "clonidine", "were", "also", "effective", "in", "reducing", "lordosis", "quotients", ",", "while", "C0025681#ent", "<e1>", ",", "phenylephrine", "and", "C0282210#ent", "<e2>", "did", "not", "alter", "receptivity", "."], "h": {"id": "C0025681", "name": "C0025681#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [19, 20]}}
{"token": ["markedly", "potentiated", "the", "inhibitory", "effect", "of", "C0025681#ent", "<e1>", "on", "the", "I(AHP", ")", ",", "whereas", "that", "for", "C0282210#ent", "<e2>", "was", "unaffected", "."], "h": {"id": "C0025681", "name": "C0025681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [16, 17]}}
{"token": ["The", "heart", "rate", "decreased", "with", "C0025681#ent", "<e1>", ",", "but", "increased", "with", "C0282210#ent", "<e2>", "."], "h": {"id": "C0025681", "name": "C0025681#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [11, 12]}}
{"token": ["C0021053#ent", "<e1>", "a", "fascinating", "but", "poorly", "understood", "group", "of", "C0012634#ent", "<e2>", "."], "h": {"id": "C0021053", "name": "C0021053#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}}
{"token": ["However", ",", "a", "C1120843#ent", "<e1>", "MAPK", ")", "inhibitor", "SB203580", "and", "a", "phosphoinositide", "3-kinase", "C3714973#ent", "<e2>", "inhibitor", "wortmannin", "had", "no", "effect", "the", "kazinol", "B-induced", "response", "."], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714973", "name": "C3714973#ent", "pos": [13, 14]}}
{"token": ["Like", "paclitaxel", ",", "C0297959#ent", "<e1>", "induced", "apoptosis", "in", "neuroblastoma", "cells", "exhibit", "constitutive", "cytoplasmic", "sequestration", "C1705526#ent", "<e2>", "and", ",", "hence", ",", "an", "impaired", "DNA-damage-dependent", "apoptosis", "."], "h": {"id": "C0297959", "name": "C0297959#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [14, 15]}}
{"token": ["Our", "data", "suggested", "that", "when", "Dane", "particles", "put", "in", "an", "environment", "of", "hepatoma", "cells", "or", "tissues", ")", ",", "the", "C0033640#ent", "<e1>", "only", "phosphorylate", "selected", "C1305923#ent", "<e2>", "in", "these", "particles", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [24, 25]}}
{"token": ["Thus", ",", "additions", "of", "apyrase", "to", "intact", "particles", "incubated", "with", "C0033640#ent", "<e1>", "32Pi", "provides", "a", "method", "for", "identifying", "internally", "exposed", "C1305923#ent", "<e2>", "in", "the", "plasma", "membranes", "a", "variety", "of", "systems", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [20, 21]}}
{"token": ["Many", "C0033640#ent", "<e1>", "activated", "strongly", "by", "the", "phosphorylation", "of", "a", "C1305923#ent", "<e2>", "activation", "loop", "that", "lies", "outside", "the", "active-site", "cleft", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [10, 11]}}
{"token": ["The", "C2936489#ent", "<e1>", "PPARs", "and", "the", "fact", "that", "chemically", "diverse", "C0243192#ent", "<e2>", "induce", "distinct", "pharmacological", "responses", "led", "to", "the", "emergence", "of", "new", "concepts", "for", "drug", "design"], "h": {"id": "C2936489", "name": "C2936489#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}}
{"token": ["PDHK", "is", "a", "highly", "specific", "C0014442#ent", "<e1>", ",", "which", "inhibits", "C1418706#ent", "<e2>", "thereby", "reducing", "the", "conversion", "of", "pyruvate", "to", "AcetylCoA", "leading", "to", "increased", "glucose", "and", "lactate", "level", "to", "various", "pathological", "disease", "states"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418706", "name": "C1418706#ent", "pos": [10, 11]}}
{"token": ["Ectopic", "expression", "of", "C1705123#ent", "<e1>", "significantly", "enhanced", "anchorage-independent", "growth", "various", "HDF", "expressing", "hTERT", ",", "C1456377#ent", "<e2>", "and", "H-RAS", "V12", "."], "h": {"id": "C1705123", "name": "C1705123#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [14, 15]}}
{"token": ["The", "effectiveness", "of", "olpadronate", "(", "C3810599#ent", "<e1>", ")", "in", "preventing", "bone", "loss", "associated", "with", "C0751039#ent", "<e2>", "treatment", "was", "also", "evaluated", "."], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [14, 15]}}
{"token": ["To", "define", "the", "timing", "of", "neural", "crest", "formation", "we", "challenged", "the", "C1539479#ent", "<e1>", "of", "presumptive", "neural", "crest", "cells", "grafting", "notochords", "C1335824#ent", "<e2>", "Shh", ")", "or", "Noggin-secreting", "cells", "different", "stages", "of", "neurulation", "in", "chick", "embryos"], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335824", "name": "C1335824#ent", "pos": [20, 21]}}
{"token": ["Overexpression", "of", "C1826697#ent", "<e1>", "increased", "arginine", "methylation", "of", "C3539665#ent", "<e2>", "and", "SLM", "proteins", "in", "cells", ",", "which", "resulted", "in", "a", "decrease", "of", "their", "poly(U)", "binding", "ability", "."], "h": {"id": "C1826697", "name": "C1826697#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539665", "name": "C3539665#ent", "pos": [8, 9]}}
{"token": ["Although", "C0012373#ent", "<e1>", "has", "been", "shown", "to", "alleviate", "C0002963#ent", "<e2>", "its", "effect", "on", "exercise-inducible", "chronic", "stable", "angina", "has", "not", "been", "objectively", "studied", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [8, 9]}}
{"token": ["This", "processing", "event", "generates", "a", "28", "kDa", "protein", "from", "the", "C3541412#ent", "<e1>", "precursor", ",", "which", "corresponds", "to", "the", "C1308226#ent", "<e2>", "respiratory", "complex", "II", "in", "maize", "mitochondria", "."], "h": {"id": "C3541412", "name": "C3541412#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1308226", "name": "C1308226#ent", "pos": [18, 19]}}
{"token": ["Chromaffin", "cells", "exposed", "to", "tetrabenazine", ",", "a", "C1254351#ent", "<e1>", "that", "depletes", "cellular", "catecholamine", "stores", ",", "increase", "their", "C0338271#ent", "<e2>", "contents", "between", "32", "hr", "and", "6", "days", "of", "treatment", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [17, 18]}}
{"token": ["Changes", "in", "total", "weight", "protein", "content", "activity", "of", "C0010760#ent", "<e1>", "been", "followed", "in", "the", "brown", "adipose", "tissue", "C1412726#ent", "<e2>", ")", "of", "golden", "hamsters", "white", "mice", "white", "rats", "to", "various", "temperatures", "."], "h": {"id": "C0010760", "name": "C0010760#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "the", "H3R", "antagonist", "(", "C0076502#ent", "<e1>", ")", "blocked", "3-NP-dependent", "behaviors", "plus", "induced", "an", "up-regulation", "of", "C1439351#ent", "<e2>", "levels", "in", "mainly", "the", "above-reported", "hamster", "amygdalar", "nuclei", "."], "h": {"id": "C0076502", "name": "C0076502#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1439351", "name": "C1439351#ent", "pos": [17, 18]}}
{"token": ["Acetaminophen", "(", "AA", ")", "is", "a", "commonly", "used", "analgesic", "and", "C0003419#ent", "<e1>", "however", ",", "when", "used", "in", "high", "doses", "it", "causes", "C0151798#ent", "<e2>", "nephrotoxic", "effects", "both", "humans", "and", "experimental", "animals"], "h": {"id": "C0003419", "name": "C0003419#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151798", "name": "C0151798#ent", "pos": [21, 22]}}
{"token": ["C0040979#ent", "<e1>", "potentiated", "the", "elevated", "renin", "secretion", "induced", "by", "C0282211#ent", "<e2>", "and", "low", "Ca", "in", "isolated", "kidneys", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [9, 10]}}
{"token": ["10(-5", ")", "mol/l", "C0040979#ent", "<e1>", "attenuated", "the", "stimulation", "of", "initial", "relaxation", "by", "C0282211#ent", "<e2>", "in", "the", "entire", "concentration", "range", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [12, 13]}}
{"token": ["Two", "of", "them", "were", "observed", "after", "an", "antibiotic", "regimen", "erythromycin", "in", "patients", "with", "C0019693#ent", "<e1>", "and", "the", "C0040830#ent", "<e2>", "henselae", "were", "identified", "in", "liver", "tissue", "Warthin-Starry", "stain", "polymerase", "chain", "reaction", "technique"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040830", "name": "C0040830#ent", "pos": [17, 18]}}
{"token": ["We", "recently", "reported", "that", "C0036442#ent", "<e1>", "pretreated", "mice", "fasted", "for", "48", "h", "developed", "C0234535#ent", "<e2>", "after", "they", "were", "allowed", "to", "eat", "ad", "libidum", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0234535", "name": "C0234535#ent", "pos": [13, 14]}}
{"token": ["The", "possible", "pre-", "and", "postsynaptic", "effects", "of", "tetraethylammonium", "(", "TEA", ";", "a", "C4284015#ent", "<e1>", "have", "been", "examined", "in", "the", "isolated", "C0751950#ent", "<e2>"], "h": {"id": "C4284015", "name": "C4284015#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [20, 21]}}
{"token": ["Cholinergic", "neurons", "participate", "in", "the", "C1951340#ent", "<e1>", "of", "thermoregulation", "and", "interventions", "affecting", "them", "alter", "the", "thermal", "response", "C0242892#ent", "<e2>", "."], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242892", "name": "C0242892#ent", "pos": [17, 18]}}
{"token": ["Efficacy", "parameters", "showed", "that", "C0015837#ent", "<e1>", "and", "aspirin", "provided", "significantly", "greater", "relief", "of", "C0029408#ent", "<e2>", "placebo", ",", "and", "that", "the", "two", "active", "drugs", "essentially", "equal", "in", "effectiveness", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [13, 14]}}
{"token": ["Ten", "of", "12", "(", "83", "%", ")", "C0038160#ent", "<e1>", "when", "treated", "with", "teicoplanin", "plus", "C0008809#ent", "<e2>", "as", "compared", "with", "2", "of", "8", "(", "25", "%", ")", "treated", "with", "gentamicin", "plus", "piperacillin", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [14, 15]}}
{"token": ["Seventeen", "patients", "with", "C0038160#ent", "<e1>", "severe", "enough", "to", "require", "hospital", "admission", "initial", "parenteral", "therapy", "treated", "with", "C0008809#ent", "<e2>", ";", "the", "results", "were", "poor", ",", "with", "clinical", "failure", "five", "and", "bacteriological", "failure", "12", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [16, 17]}}
{"token": ["The", "transcription", "unit", "encodes", "beta-globin", "(", "major", ")", "mRNA", "has", "been", "examined", "by", "analysis", "of", "nascent", "labeled", "RNA", "from", "the", "nuclei", "of", "mouse", "erythroleukemia", "cells", "treated", "with", "C0991617#ent", "<e1>", "that", "induce", "C1415481#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1415481", "name": "C1415481#ent", "pos": [31, 32]}}
{"token": ["The", "remaining", "2", "patients", "had", "C1418963#ent", "<e1>", ",", "of", "2", "and", "11", "months", "C0720099#ent", "<e2>", "."], "h": {"id": "C1418963", "name": "C1418963#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [13, 14]}}
{"token": ["However", ",", "C0125988#ent", "<e1>", "inhibited", "monosynaptic", "reflex", "induced", "by", "(+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane", ",", "a", "C0162755#ent", "<e2>", "in", "spinalized", "rats", "markedly", ",", "and", "5-HT", "depletion", "by", "DL-p-chlorophenylalanine", "inhibited", "the", "depressive", "effect", "of", "C0125988#ent", "<e1>", "on", "the", "monosynaptic", "reflex"], "h": {"id": "C0125988", "name": "C0125988#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162755", "name": "C0162755#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "interaction", "of", "Mg2", "+", "and", "Ca2", "+", "in", "formation", "of", "the", "hexagonal", "lattice", "structure", "by", "the", "electrodialyzed", "C2697656#ent", "<e1>", "suspended", "in", "50", "mM", "C0041175#ent", "<e2>", "pH", "8.5", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0041175", "name": "C0041175#ent", "pos": [25, 26]}}
{"token": ["Blockage", "of", "C1705026#ent", "<e1>", "processing", "to", "ICD4", "by", "C0379528#ent", "<e2>", "MCF-7", "cells", "sensitive", "to", "growth", "inhibition", "TGF-beta", "."], "h": {"id": "C1705026", "name": "C1705026#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0379528", "name": "C0379528#ent", "pos": [8, 9]}}
{"token": ["Comprehensive", "searches", "maize", "EST", "data", "allowed", "us", "to", "identify", "8", "novel", "C0010646#ent", "<e1>", "CC", ")", "C1417679#ent", "<e2>", "in", "addition", "to", "the", "previously", "known", "C1417679#ent", "<e2>", "CCI", "and", "CCII", "."], "h": {"id": "C0010646", "name": "C0010646#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["More", "than", "60,000", "patients", "suffering", "from", "C0403719#ent", "<e1>", "have", "been", "treated", "successfully", ",", "what", "made", "surgical", "removal", "their", "C0392525#ent", "<e2>", "."], "h": {"id": "C0403719", "name": "C0403719#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [18, 19]}}
{"token": ["Because", "lesions", "at", "this", "site", "can", "produce", "the", "post-stroke", "C1412041#ent", "<e1>", "this", "finding", "supports", "the", "proposal", "that", "C0234243#ent", "<e2>", "from", "loss", "of", "the", "normal", "inhibition", "of", "pain", "by", "cold", "."], "h": {"id": "C1412041", "name": "C1412041#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0234243", "name": "C0234243#ent", "pos": [17, 18]}}
{"token": ["Only", "26.3", "%", "of", "Muscovite", "youth", "report", "being", "taught", "about", "C1456617#ent", "<e1>", "school", ",", "and", "just", "41.7", "%", "indicate", "discussion", "of", "C0497169#ent", "<e2>", "occurred", "with", "parents", "or", "other", "familial", "adults"], "h": {"id": "C1456617", "name": "C1456617#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0497169", "name": "C0497169#ent", "pos": [21, 22]}}
{"token": ["Incubation", "of", "permeabilized", "PC12", "cells", "soluble", "C1455060#ent", "<e1>", "GTPase", ",", "but", "not", "RhoA", "or", "Rab3A", "C0018296#ent", "<e2>", ",", "strongly", "inhibited", "GTP-dependent", "exocytosis", "."], "h": {"id": "C1455060", "name": "C1455060#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [15, 16]}}
{"token": ["Then", ",", "for", "nine", "more", "weeks", ",", "the", "preparation", "of", "C0003486#ent", "<e1>", "and", "cyclophosphamide", "(", "C1413662#ent", "<e2>", ")", ",", "alone", "or", "in", "combination", "with", "C0003486#ent", "<e1>", ",", "were", "administered", "in", "weekly", "doses"], "h": {"id": "C1413662", "name": "C1413662#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [10, 11]}}
{"token": ["We", "report", "herein", "that", "filarial", "cystatin", ",", "a", "secreted", "C3536890#ent", "<e1>", "filarial", "nematodes", "suppresses", "Th2-related", "inflammation", "and", "the", "ensuing", "C0038218#ent", "<e2>", "a", "murine", "model", "of", "OVA-induced", "allergic", "airway", "responsiveness", "."], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038218", "name": "C0038218#ent", "pos": [19, 20]}}
{"token": ["This", "finding", "may", "contribute", "to", "the", "process", "that", "leads", "to", "C0085786#ent", "<e1>", "in", "a", "minority", "of", "cases", "of", "C0019189#ent", "<e2>"], "h": {"id": "C0085786", "name": "C0085786#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019189", "name": "C0019189#ent", "pos": [18, 19]}}
{"token": ["Tissues", "with", "high", "C1412305#ent", "<e1>", "levels", "showed", "low", "AK2", "levels", "and", "vice", "versa", ",", "suggesting", "that", "C1420295#ent", "<e2>", "expressions", "of", "the", "C1412305#ent", "<e1>", "and", "AK2", "genes", "are", "inversely", "regulated", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412305", "name": "C1412305#ent", "pos": [3, 4]}}
{"token": ["C3853886#ent", "<e1>", "PI", "3-kinases", "are", "key", "signaling", "components", "downstream", "of", "tyrosine", "kinases", "C0034678#ent", "<e2>", ",", "regulating", "many", "different", "cellular", "functions", "contributing", "to", "tumorigenesis", "."], "h": {"id": "C3853886", "name": "C3853886#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [12, 13]}}
{"token": ["C0025041#ent", "<e1>", "produced", "a", "fall", "in", "C3203102#ent", "<e2>", "clearance", "from", "27.0", "to", "21.2", "ml/min", "."], "h": {"id": "C0025041", "name": "C0025041#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3203102", "name": "C3203102#ent", "pos": [6, 7]}}
{"token": ["At", "present", ",", "43", "mutations", ",", "including", "5", "discovered", "in", "our", "laboratory", ",", "have", "been", "reported", "in", "the", "C1420191#ent", "<e1>", "patients", "with", "C0010691#ent", "<e2>", "."], "h": {"id": "C1420191", "name": "C1420191#ent", "pos": [18, 19]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [22, 23]}}
{"token": ["Mutations", "in", "any", "of", "the", "two", "genes", "coding", "for", "the", "subunits", "of", "system", "b(0,+", ")", "(", "C1420191#ent", "<e1>", "and", "b(0,+)AT", ")", "lead", "to", "C0010691#ent", "<e2>", "(", "MIM", "220100", ")", "."], "h": {"id": "C1420191", "name": "C1420191#ent", "pos": [16, 17]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [23, 24]}}
{"token": ["Mutational", "analysis", "candidate", "genes", "including", "human", "synaptotagmin", "II", "C1420498#ent", "<e1>", "synaptobrevin", "I", "SNAP", "25", ",", "CACNA1A", ",", "CACNB2", ",", "and", "C0245959#ent", "<e2>", ",", "was", "unrevealing", "."], "h": {"id": "C1420498", "name": "C1420498#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0245959", "name": "C0245959#ent", "pos": [20, 21]}}
{"token": ["Throughout", "the", "modern", "era", "there", "have", "been", "attempts", "to", "determine", "whether", "there", "are", "populations", "of", "patients", "selectively", "responsible", "to", "specific", "C0035064#ent", "<e1>", "(", "e.g.", "serotonin", "versus", "C3537046#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3537046", "name": "C3537046#ent", "pos": [26, 27]}}
{"token": ["In", "contrast", ",", "3", "of", "4", "patients", "who", "underwent", "thoracotomy", "for", "C0008733#ent", "<e1>", "permanent", "relief", "of", "their", "C0032227#ent", "<e2>"], "h": {"id": "C0008733", "name": "C0008733#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0032227", "name": "C0032227#ent", "pos": [17, 18]}}
{"token": ["Tapasin", "organizes", "a", "peptide-loading", "complex", "(", "C0031669#ent", "<e1>", ")", "by", "recruiting", "C0024518#ent", "<e2>", "accessory", "chaperones", "the", "N-terminal", "regions", "(", "N", "domains", "of", "the", "TAP", "subunits", "TAP1", "and", "TAP2", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [11, 12]}}
{"token": ["This", "correlates", "with", "a", "substantially", "reduced", "recruitment", "of", "accessory", "chaperones", "the", "C0031669#ent", "<e1>", "demonstrating", "their", "important", "role", "in", "the", "quality", "control", "C0024518#ent", "<e2>", "loading", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [21, 22]}}
{"token": ["Anti-promotion", "properties", "were", "assessed", "by", "measuring", "the", "effects", "of", "C0912024#ent", "<e1>", ",", "robinetin", "and", "C0063491#ent", "<e2>", "on", "induction", "of", "ornithine", "decarboxylase", "activity", "ODC", ")", "in", "mouse", "epidermis", "17", "nmol", "12-O-tetradecanoyl", "phorbol-13-acetate", "(", "TPA", ")", "."], "h": {"id": "C0912024", "name": "C0912024#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0063491", "name": "C0063491#ent", "pos": [14, 15]}}
{"token": ["Treatment", "with", "100", "mumol", "C0912024#ent", "<e1>", "or", "50", "or", "100", "mumol", "C0063491#ent", "<e2>", "in", "non-TPA-treated", "mouse", "skin", "caused", "elevations", "in", "epidermal", "ODC", "."], "h": {"id": "C0912024", "name": "C0912024#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0063491", "name": "C0063491#ent", "pos": [11, 12]}}
{"token": ["The", "influence", "of", "MOR", "and", "ETHA", "on", "C3541394#ent", "<e1>", "dependent", "on", "Ca-binding", "proteins", "phosphodiesterase", "and", "C0001478#ent", "<e2>", "was", "not", "observed", "up", "to", "100", "mumol/l", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001478", "name": "C0001478#ent", "pos": [15, 16]}}
{"token": ["In", "these", "cases", ",", "C1420703#ent", "<e1>", "was", "involved", "in", "2", "different", "fusion", "genes", "C3537362#ent", "<e2>", ")", "and", "TFG-ALK(L", ")", ",", "coding", "respectively", "85-kD", "and", "97-kD", "chimeric", "proteins"], "h": {"id": "C1420703", "name": "C1420703#ent", "pos": [4, 5]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3537362", "name": "C3537362#ent", "pos": [13, 14]}}
{"token": ["In", "severe", "chronic", "congestive", "cardiac", "failure", "physician", "has", "the", "choice", "of", "two", "families", "of", "positive", "C0242913#ent", "<e1>", "the", "direct", "C0030512#ent", "<e2>", "and", "the", "phosphodiesterase", "inhibitors"], "h": {"id": "C0242913", "name": "C0242913#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030512", "name": "C0030512#ent", "pos": [19, 20]}}
{"token": ["The", "loss", "of", "C1418706#ent", "<e1>", "in", "the", "C0771711#ent", "<e2>", "itself", "was", "accompanied", "by", "the", "localized", "loss", "of", "IDO", "and", "the", "acceleration", "of", "insulitis", "."], "h": {"id": "C1418706", "name": "C1418706#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [7, 8]}}
{"token": ["The", "inactivation", "of", "the", "C1705516#ent", "<e1>", "activities", "by", "both", "C1413902#ent", "<e2>", "and", "NG-amino-L-arginine", "in", "preincubations", "required", "the", "presence", "of", "oxygen", "and", "Ca2", "+", ",", "consistent", "with", "inactivation", "mechanism", "that", "requires", "active", "metabolism", "C1705516#ent", "<e1>", "."], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413902", "name": "C1413902#ent", "pos": [9, 10]}}
{"token": ["Depletion", "of", "glutathione", "was", "associated", "with", "excessive", "oxidant", "burden", "and", "reduced", "transcription", "and", "activity", "of", "the", "rate-limiting", "enzyme", "for", "glutathione", "synthesis", ",", "C1522376#ent", "<e1>", "together", "with", "the", "glutathione-dependent", "antioxidant", "enzyme", ",", "C0017822#ent", "<e2>"], "h": {"id": "C1522376", "name": "C1522376#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0017822", "name": "C0017822#ent", "pos": [31, 32]}}
{"token": ["The", "enzymes", "included", "those", "required", "for", "glutathione", "synthesis", "C1522376#ent", "<e1>", "glutathione", "synthetase", "as", "well", "as", "glutathione-S-transferase", ",", "C0017822#ent", "<e2>", "glutathione", "reductase"], "h": {"id": "C1522376", "name": "C1522376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017822", "name": "C0017822#ent", "pos": [17, 18]}}
{"token": ["A", "double", "blind", ",", "randomized", "trial", "two", "regimens", "of", "nebulized", "C0029193#ent", "<e1>", "was", "conducted", "in", "patients", "presenting", "to", "an", "Emergency", "Department", "an", "C0004096#ent", "<e2>", "exacerbation", "."], "h": {"id": "C0029193", "name": "C0029193#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [22, 23]}}
{"token": ["C0029193#ent", "<e1>", "administered", "daily", "for", "3", "months", "to", "C0004096#ent", "<e2>", "children", "."], "h": {"id": "C0029193", "name": "C0029193#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [8, 9]}}
{"token": ["The", "dose-related", "effects", "of", "inhaled", "5", "%", "C0029193#ent", "<e1>", "solution", "in", "C0004096#ent", "<e2>", "children", "between", "the", "ages", "of", "six", "and", "12", "years", "with", "acute", "bronchospasm", "evaluated", "."], "h": {"id": "C0029193", "name": "C0029193#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}}
{"token": ["Efficacy", "of", "oral", "antiviral", "therapies", ",", "ie", ",", "acyclovir", ",", "valacyclovir", "(", "VACV", ")", ",", "and", "C0209227#ent", "<e1>", ",", "for", "suppression", "of", "recurrent", "C0019342#ent", "<e2>", "studied", "at", "different", "doses", "and", "regimens", "."], "h": {"id": "C0209227", "name": "C0209227#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0019342", "name": "C0019342#ent", "pos": [23, 24]}}
{"token": ["Aciclovir", ",", "valaciclovir", "and", "C0209227#ent", "<e1>", "are", "effective", "treatment", "for", "C0019342#ent", "<e2>", "primary", "infection", "curative", "and", "preventive", "treatment", "recurrence", ")", ",", "but", "none", "of", "these", "compounds", "alters", "the", "natural", "history", "the", "infection", "."], "h": {"id": "C0209227", "name": "C0209227#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0019342", "name": "C0019342#ent", "pos": [10, 11]}}
{"token": ["To", "study", "this", ",", "the", "activities", "of", "hepatic", "lipase", "lipoprotein", "lipase", "determined", "in", "control", "subjects", "in", "two", "patients", "with", "C0020597#ent", "<e1>", "and", "in", "three", "patients", "with", "C0000744#ent", "<e2>", "administration", "of", "heparin", "."], "h": {"id": "C0020597", "name": "C0020597#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [26, 27]}}
{"token": ["The", "phenol", "compounds", "used", "as", "C0013227#ent", "<e1>", "the", "cases", "of", "various", "C0036830#ent", "<e2>", "of", "blood", ",", "breathing", ",", "food", ",", "and", "urinary", "circuit", "and", "in", "dermatology", "as", "well", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036830", "name": "C0036830#ent", "pos": [11, 12]}}
{"token": ["Important", "vascular", "etiologies", "be", "considered", "are", "popliteal", "artery", "entrapment", "syndrome", "C0070610#ent", "<e1>", ")", ",", "endofibrotic", "disease", ",", "popliteal", "artery", "aneurysm", "cystic", "adventitial", "disease", "and", "C0002949#ent", "<e2>"], "h": {"id": "C0070610", "name": "C0070610#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002949", "name": "C0002949#ent", "pos": [24, 25]}}
{"token": ["Our", "studies", "reveal", "that", "the", "gene", "for", "cytosolic", "SHMT", "(", "C3538792#ent", "<e1>", ")", "maps", "to", "the", "critical", "interval", "Smith-Magenis", "syndrome", "C1419249#ent", "<e2>", ")", "on", "chromosome", "17p11.2"], "h": {"id": "C3538792", "name": "C3538792#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419249", "name": "C1419249#ent", "pos": [20, 21]}}
{"token": ["Blastokinin", "or", "C1421318#ent", "<e1>", "(", "utg", ")", ",", "a", "C1426033#ent", "<e2>", "first", "discovered", "in", "the", "pregnant", "rabbit", "uterus", ",", "is", "also", "a", "potent", "PLA2", "inhibitor", ",", "but", "genetically", "distinct", "from", "lipocortins", "."], "h": {"id": "C1421318", "name": "C1421318#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426033", "name": "C1426033#ent", "pos": [9, 10]}}
{"token": ["We", "distinguished", "at", "least", "three", "types", "of", "drugs", ":", "C0031507#ent", "<e1>", "and", "ralitoline", "selectively", "prevented", "C0014549#ent", "<e2>", "the", "other", "drugs", "tested", "were", "active", "against", "all", "seizure", "types", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [15, 16]}}
{"token": ["Urines", "from", "patients", "with", "C0023806#ent", "<e1>", "mannosidosis", ",", "fucosidosis", ",", "aspartylglycosaminuria", ",", "and", "C0017921#ent", "<e2>", "be", "distinguished", "by", "thin-layer", "chromatography"], "h": {"id": "C0023806", "name": "C0023806#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017921", "name": "C0017921#ent", "pos": [13, 14]}}
{"token": ["These", "C0031727#ent", "<e1>", "are", "regulated", "by", "mammalian", "C1453853#ent", "<e2>", "MSTs", ")", "and", "Mps", "one", "binder", "(", "MOB", ")", "1", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1453853", "name": "C1453853#ent", "pos": [7, 8]}}
{"token": ["Our", "results", "suggest", "that", "methylation", "silencing", "of", "C3273731#ent", "<e1>", "is", "one", "of", "the", "important", "mechanisms", "of", "C0907533#ent", "<e2>", "activation", "of", "the", "JAK/STAT", "pathway", "in", "cancer", "pathogenesis"], "h": {"id": "C3273731", "name": "C3273731#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [16, 17]}}
{"token": ["Ocular", "sequelae", "C0042166#ent", "<e1>", ",", "glaucoma", ",", "cataracts", ",", "and", "C0521694#ent", "<e2>"], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0521694", "name": "C0521694#ent", "pos": [10, 11]}}
{"token": ["The", "infantile", "form", "of", "neuronal", "ceroid", "lipofuscinosis", "INCL", ";", "C1418854#ent", "<e1>", ")", "is", "the", "earliest", "onset", "form", "the", "C0027877#ent", "<e2>", "NCL", ")", ",", "a", "group", "of", "progressive", "encephalopathies", "of", "children", "."], "h": {"id": "C1418854", "name": "C1418854#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027877", "name": "C0027877#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "C1418854#ent", "<e1>", "PPT", ")", "gene", "cause", "infantile", "C0027877#ent", "<e2>", "INCL", ")", ",", "the", "clinical", "manifestations", "which", "include", "the", "early", "loss", "of", "followed", "by", "deterioration", "of", "brain", "functions"], "h": {"id": "C1418854", "name": "C1418854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027877", "name": "C0027877#ent", "pos": [10, 11]}}
{"token": ["As", "in", "C0080323#ent", "<e1>", "HTLV-III", ",", "the", "polymerase", "(", "pol", ")", "and", "C0017343#ent", "<e2>", "EIAV", "do", "not", "overlap", "."], "h": {"id": "C0080323", "name": "C0080323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017343", "name": "C0017343#ent", "pos": [12, 13]}}
{"token": ["The", "two", "C0086376#ent", "<e1>", "bind", "to", "a", "region", "of", "C1413850#ent", "<e2>", "that", "contains", "a", "Cys-box", "motif", "and", "the", "third", "cytoskeleton-associated", "protein-glycine", "conserved", "CAP-Gly", ")", "domain", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413850", "name": "C1413850#ent", "pos": [9, 10]}}
{"token": ["This", "phase-I", "trial", "was", "primarily", "performed", "to", "evaluate", "the", "maximum", "tolerable", "dose", "(", "MTD", ")", "and", "dose-limiting", "toxicity", "C3273706#ent", "<e1>", ")", "of", "a", "combination", "chemotherapy", "C0146224#ent", "<e2>", "and", "ifosfamide", "using", "a", "5-day", "schedule", "."], "h": {"id": "C3273706", "name": "C3273706#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0146224", "name": "C0146224#ent", "pos": [25, 26]}}
{"token": ["No", "C3273706#ent", "<e1>", "was", "observed", "in", "the", "first", "3", "patients", "in", "scheme", "C", "C0146224#ent", "<e2>", "0.45", "mg", "m(-2", ")", "d(-1", ")", ")", "."], "h": {"id": "C3273706", "name": "C3273706#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0146224", "name": "C0146224#ent", "pos": [13, 14]}}
{"token": ["Our", "data", "suggest", "that", "C0075755#ent", "<e1>", "is", "a", "safe", "and", "effective", "C0013227#ent", "<e2>", "for", "children", "who", "have", "undergone", "open", "heart", "surgery"], "h": {"id": "C0075755", "name": "C0075755#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [11, 12]}}
{"token": ["To", "study", "the", "effects", "of", "other", "membrane", "components", "C3272447#ent", "<e1>", "activity", ",", "liposomes", "were", "prepared", "with", "purified", "human", "C1367455#ent", "<e2>", "LPS", "."], "h": {"id": "C3272447", "name": "C3272447#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1367455", "name": "C1367455#ent", "pos": [18, 19]}}
{"token": ["ii", ")", "the", "inhibition", "of", "tau", "and", "C0244988#ent", "<e1>", "phosphorylations", "correlated", "with", "increase", "in", "C1826563#ent", "<e2>", "activation", "in", "NSE/hTau-", "cells", "."], "h": {"id": "C0244988", "name": "C0244988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826563", "name": "C1826563#ent", "pos": [14, 15]}}
{"token": ["We", "stress", "the", "relevance", "of", "polymorphic", "marker", "haplotype", "analysis", "the", "importance", "of", "family", "study", "C0019247#ent", "<e1>", "such", "as", "C0031485#ent", "<e2>", ",", "to", "avoid", "incorrect", "diagnosis", "and", "genetic", "counseling"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [18, 19]}}
{"token": ["Screening", "of", "newborn", "infants", "C0019247#ent", "<e1>", "over", "35", "years", "ago", "as", "a", "public", "health", "measure", "prevent", "mental", "retardation", "C0031485#ent", "<e2>", "(", "PKU", ")", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [18, 19]}}
{"token": ["Both", "leucocyte", "fractions", "were", "found", "to", "contain", "retinol", ",", "C0022265#ent", "<e1>", "an", "additional", "C0035339#ent", "<e2>", ";", "C0022265#ent", "<e1>", "40", "%", "of", "retinoids", "in", "some", "samples", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [9, 10]}, "relation": "has_chemical_structure", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [13, 14]}}
{"token": ["The", "spin-adducts", "were", "eluted", "in", "the", "order", "C0022265#ent", "<e1>", "retinol", ",", "retinyl", "acetate", "in", "a", "similar", "manner", "to", "the", "C0035339#ent", "<e2>", "themselves", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [7, 8]}, "relation": "has_chemical_structure", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [19, 20]}}
{"token": ["Melatonin", "is", "a", "recognized", "antioxidant", "with", "high", "potential", "as", "a", "C0033613#ent", "<e1>", "many", "conditions", "related", "to", "oxidative", "stress", "as", "C0751870#ent", "<e2>", "ischemia/reperfusion", "syndromes", ",", "sepsis", "and", "aging", "."], "h": {"id": "C0033613", "name": "C0033613#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [19, 20]}}
{"token": ["Comparison", "of", "these", "findings", "in", "Israeli", "C1875400#ent", "<e1>", "with", "those", "in", "panmictic", "populations", "seems", "to", "imply", "that", "the", "C0678933#ent", "<e2>", "not", "identical", "in", "the", "various", "C1875400#ent", "<e1>", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}}
{"token": ["Gene", "amplification", "overexpression", "of", "C0029016#ent", "<e1>", "and", "growth", "factors/receptors", "as", "C1704823#ent", "<e2>", ",", "K-sam", ",", "c-erbB2", ",", "EGF", "and", "EGF", "receptor", "biological", "marker", "biological", "malignancy"], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704823", "name": "C1704823#ent", "pos": [10, 11]}}
{"token": ["To", "reveal", "the", "role", "of", "C0029016#ent", "<e1>", "in", "Epstein-Barr", "virus", "gastric", "carcinomas", "the", "amplification", "and", "overexpression", "of", "the", "C1704823#ent", "<e2>", "examined", "by", "a", "competitive", "polymerase", "chain", "reaction", "immunohistochemistry", ",", "respectively", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704823", "name": "C1704823#ent", "pos": [18, 19]}}
{"token": ["These", "include", "the", "down-regulation", "of", "major", "tumor", "suppressor", "genes", "thyroid", "iodide-metabolizing", "genes", "and", "the", "up-regulation", "of", "C0029016#ent", "<e1>", "such", "as", "vascular", "endothelial", "growth", "factor", "matrix", "metalloproteinases", "nuclear", "transcription", "factor", "kappaB", "and", "C1704823#ent", "<e2>", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704823", "name": "C1704823#ent", "pos": [31, 32]}}
{"token": ["Results", "were", ":", "candidiasis", "5.8", "%", ";", "C0085166#ent", "<e1>", "BV", ")", "37.2", "%", ";", "trichomoniasis", "15.1", "%", ";", "C0151175#ent", "<e2>", "0.7", "%", ";", "chlamydial", "infection", "%", ";", "syphilis", "0", "%", "."], "h": {"id": "C0085166", "name": "C0085166#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0151175", "name": "C0151175#ent", "pos": [18, 19]}}
{"token": ["Urine", "sample", "high", "vaginal", "swabs", "blood", "samples", "investigated", "for", "C0085166#ent", "<e1>", "candidiasis", ",", "trichomoniasis", ",", "C0151175#ent", "<e2>", ",", "HIV", "and", "syphilis", "."], "h": {"id": "C0085166", "name": "C0085166#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151175", "name": "C0151175#ent", "pos": [15, 16]}}
{"token": ["Bartonella", "(", "C0004771#ent", "<e1>", ")", "quintana", "is", "a", "fastidious", "gram-negative", "bacterium", "to", "cause", "trench", "fever", "C0085434#ent", "<e2>", "and", "endocarditis", "."], "h": {"id": "C0004771", "name": "C0004771#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085434", "name": "C0085434#ent", "pos": [15, 16]}}
{"token": ["Several", "studies", "have", "shown", "that", "the", "selective", "serotonin", "reuptake", "inhibitors", "C1579361#ent", "<e1>", ")", "and", "the", "serotonin", "and", "C1579361#ent", "<e1>", "SNRIs", ")", "have", "higher", "remission", "rates", "than", "other", "antidepressant", "medications", "."], "h": {"id": "C1579361", "name": "C1579361#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1579361", "name": "C1579361#ent", "pos": [10, 11]}}
{"token": ["The", "authors", "present", "here", "two", "cases", "of", "Parkinson's", "disease", "depression", "refractory", "C1579361#ent", "<e1>", "treatment", ",", "who", "experienced", "a", "complete", "remission", "after", "replacing", "the", "ongoing", "C1579361#ent", "<e1>", "with", "a", "serotonin-noradrenalin", "reuptake", "inhibitor", "C1579361#ent", "<e1>", ")", ",", "milnacipran", "."], "h": {"id": "C1579361", "name": "C1579361#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1579361", "name": "C1579361#ent", "pos": [11, 12]}}
{"token": ["Limited", "proteolysis", "of", "rough", "microsomes", "decreased", "the", "C0086376#ent", "<e1>", "capacity", "and", "prevented", "GTP", "from", "suppressing", "the", "latency", "of", "C0065687#ent", "<e2>", "and", "of", "the", "synthesis", "of", "dolichol-linked", "chitobiose", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0065687", "name": "C0065687#ent", "pos": [18, 19]}}
{"token": ["C0005741#ent", "<e1>", "include", "sequelae", "including", "C0314719#ent", "<e2>", "corneal", "and", "lid", "contour", "."], "h": {"id": "C0005741", "name": "C0005741#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0314719", "name": "C0314719#ent", "pos": [5, 6]}}
{"token": ["Thus", "we", "demonstrate", "that", "a", "quantitative", "kinetic", "study", "on", "the", "C0033551#ent", "<e1>", "be", "performed", "in", "the", "presence", "of", "C0012422#ent", "<e2>", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012422", "name": "C0012422#ent", "pos": [18, 19]}}
{"token": ["C0033551#ent", "<e1>", "arachidonic", "acid", "not", "be", "examined", "in", "the", "absence", "of", "C0012422#ent", "<e2>", "because", "extensive", "bleaching", "occurred", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012422", "name": "C0012422#ent", "pos": [11, 12]}}
{"token": ["C1861923#ent", "<e1>", "a", "rare", "variant", "of", "C1861922#ent", "<e2>", "affecting", "bone", "and", "connecting", "tissue"], "h": {"id": "C1861923", "name": "C1861923#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C1861922", "name": "C1861922#ent", "pos": [6, 7]}}
{"token": ["This", "observation", "and", "similar", "cases", "previously", "reported", "indicate", "that", "C1861923#ent", "<e1>", "is", "a", "variable", "feature", "in", "C1861922#ent", "<e2>"], "h": {"id": "C1861923", "name": "C1861923#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C1861922", "name": "C1861922#ent", "pos": [16, 17]}}
{"token": ["In", "accordance", "with", "two", "previous", "case", "reports", "the", "present", "findings", "suggest", "that", "a", "C1861923#ent", "<e1>", "variant", "without", "C1861922#ent", "<e2>", "may", "exist", "."], "h": {"id": "C1861923", "name": "C1861923#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C1861922", "name": "C1861922#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "C0919490#ent", "<e1>", "mediates", "GM-CSF-dependent", "effects", "on", "terminal", "differentiation", "C1860224#ent", "<e2>", "regulating", "innate", "immune", "functions", "surfactant", "catabolism", "by", "C1860224#ent", "<e2>", "."], "h": {"id": "C0919490", "name": "C0919490#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1860224", "name": "C1860224#ent", "pos": [11, 12]}}
{"token": ["A", "deletion", "in", "the", "coding", "sequence", "C1367710#ent", "<e1>", "leads", "to", "C0343047#ent", "<e2>", "and", "susceptibility", "."], "h": {"id": "C1367710", "name": "C1367710#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0343047", "name": "C0343047#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "the", "acute", "effects", "of", "ethanol", "(", "ET", ")", "and", "C0030438#ent", "<e1>", "(", "AC", ")", "were", "determined", "on", "the", "production", "of", "C0812281#ent", "<e2>", "in", "isolated", "rat", "hepatic", "stellate", "cells"], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [24, 25]}}
{"token": ["The", "UNS", "sum", "score", "reliably", "distinguishes", "patients", "with", "the", "C1834372#ent", "<e1>", "patients", "with", "C0520680#ent", "<e2>", "multiple", "sclerosis", "and", "epilepsy", "."], "h": {"id": "C1834372", "name": "C1834372#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0520680", "name": "C0520680#ent", "pos": [13, 14]}}
{"token": ["Importantly", ",", "unlike", "ATRA", ",", "this", "synergy", "was", "obtained", "at", "very", "low", "C2987634#ent", "<e1>", "concentrations", "and", "occurred", "in", "other", "ATRA", "maturation-resistant", "C1859592#ent", "<e2>"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1859592", "name": "C1859592#ent", "pos": [21, 22]}}
{"token": ["The", "anti-IL-6", "monoclonal", "antibody", "unable", "to", "protect", "against", "mTNF", "in", "mice", "sensitized", "by", "galactosamine", ",", "the", "C1579268#ent", "<e1>", "RU38486", "or", "human", "(", "h", ")", "C1522428#ent", "<e2>"], "h": {"id": "C1579268", "name": "C1579268#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [24, 25]}}
{"token": ["Administration", "of", "C0023556#ent", "<e1>", "to", "patients", "with", "C0024115#ent", "<e2>", "to", "an", "increase", "of", "the", "initially", "reduced", "T", "and", "B", "lymphocyte", "counts", "."], "h": {"id": "C0023556", "name": "C0023556#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "C0020538#ent", "<e1>", "although", "prevalent", "in", "C0175702#ent", "<e2>", "does", "not", "have", "a", "well-defined", "mechanism", "in", "this", "syndrome", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [7, 8]}}
{"token": ["PKN", "is", "a", "fatty", "acid-", "C0072402#ent", "<e1>", "having", "a", "catalytic", "domain", "to", "C0033634#ent", "<e2>"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [12, 13]}}
{"token": ["PKN", "is", "a", "C0072402#ent", "<e1>", "which", "has", "a", "catalytic", "domain", "homologous", "to", "that", "of", "C0033634#ent", "<e2>", "PKC", ")", "in", "the", "carboxyl-terminal", "region", "three", "repeats", "of", "the", "antiparallel", "coiled", "coil", "ACC", ")", "domain", "in", "the", "amino-terminal", "region"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [14, 15]}}
{"token": ["administration", "of", "C2348680#ent", "<e1>", ",", "a", "fraction", "isolated", "from", "C1415001#ent", "<e2>", ",", "showed", "high", "step-through", "latency", "on", "scopolamine-induced", "amnesia", "."], "h": {"id": "C2348680", "name": "C2348680#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415001", "name": "C1415001#ent", "pos": [9, 10]}}
{"token": ["To", "report", "the", "importance", "of", "a", "rare", "organic", "acid", "metabolic", "disorder", "C1855995#ent", "<e1>", "and", "its", "characteristic", "neuroimaging", "cerebral", "white", "matter", "abnormalities", "a", "case", "of", "C0014544#ent", "<e2>", "."], "h": {"id": "C1855995", "name": "C1855995#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [24, 25]}}
{"token": ["Comparison", "of", "the", "C1413914#ent", "<e1>", "cDNA", "sequence", "the", "cDNA", "sequences", "DAZ", "and", "C1704939#ent", "<e2>", "revealed", "two", "prominent", "differences", "."], "h": {"id": "C1413914", "name": "C1413914#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [12, 13]}}
{"token": ["Microtubule-depolymerizing", "drugs", ",", "such", "as", "colchicine", ",", "vinblastine", "sulfate", "colcemide", "and", "podophyllotoxin", ",", "cause", "an", "apparent", "inhibition", "of", "the", "ability", "of", "rat", "C0669372#ent", "<e1>", "to", "degrade", "C0052499#ent", "<e2>", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0052499", "name": "C0052499#ent", "pos": [26, 27]}}
{"token": ["In", "animals", "sacrificed", "11", "days", "after", "the", "streptozotocin", "injection", ",", "the", "total", "capacity", "of", "C0669372#ent", "<e1>", "to", "bind", "C0052499#ent", "<e2>", "was", "about", "70", "%", "of", "the", "normal", "level", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0052499", "name": "C0052499#ent", "pos": [18, 19]}}
{"token": ["The", "total", "capacity", "of", "C0669372#ent", "<e1>", "to", "bind", "C0052499#ent", "<e2>", "was", "measured", "on", "normal", "and", "streptozotocin", "diabetic", "rats", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0052499", "name": "C0052499#ent", "pos": [8, 9]}}
{"token": ["This", "suggests", "that", "other", "factors", ",", "such", "as", "TRAIL-induced", "C1417708#ent", "<e1>", "activation", "or", "C0003015#ent", "<e2>", "c-FLIP", ",", "are", "involved", "in", "determining", "differential", "sensitivity", "to", "TRAIL", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [13, 14]}}
{"token": ["Islow", "is", "highly", "sensitive", "to", "C0000477#ent", "<e1>", "but", "is", "insensitive", "to", "tetraethylammonium", ",", "alpha-dendrotoxin", ",", "and", "C0082359#ent", "<e2>", "."], "h": {"id": "C0000477", "name": "C0000477#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0082359", "name": "C0082359#ent", "pos": [16, 17]}}
{"token": ["Upstream", "activators", "p38", ",", "C0907533#ent", "<e1>", "active", "(", "ca", ")", "C4084906#ent", "<e2>", "and", "MKK6", ",", "were", "also", "cloned", ",", "purified", ",", "and", "used", "to", "activate", "each", "p38", "isoform", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4084906", "name": "C4084906#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "activation", "of", "p38", "MAPK", "C0907533#ent", "<e1>", "active", "MKK6b", "or", "C4084906#ent", "<e2>", "was", "not", "sufficient", "to", "induce", "MMP-13", "expression", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4084906", "name": "C4084906#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "describe", "that", "the", "immunomodulatory", "C1333196#ent", "<e1>", "IFN-beta", "induces", "SOCS-1", "and", "C3275257#ent", "<e2>", "expression", "in", "primary", "astrocytes", "at", "the", "transcriptional", "level"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3275257", "name": "C3275257#ent", "pos": [15, 16]}}
{"token": ["Results", "described", "in", "the", "current", "paper", "clearly", "show", "that", "C1418296#ent", "<e1>", "initiates", "secretion", "of", "cytokines", "interleukin-4", "IL-4", ")", ",", "C1705592#ent", "<e2>", ",", "IL-10", ",", "IL-13", ",", "macrophage", "inflammatory", "protein-1beta", "(", "MIP-1beta", ")", "from", "such", "tumor", "cells"], "h": {"id": "C1418296", "name": "C1418296#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [19, 20]}}
{"token": ["Based", "on", "these", "results", ",", "we", "propose", "that", "there", "is", "a", "common", "genetic", "pathway", "C0024437#ent", "<e1>", "includes", "genes", "for", "both", "recessive", "and", "dominant", "C1855465#ent", "<e2>", "."], "h": {"id": "C0024437", "name": "C0024437#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1855465", "name": "C1855465#ent", "pos": [23, 24]}}
{"token": ["A", "39-year-old", "male", "with", "a", "history", "of", "cardiac", "murmur", "early", "childhood", "diagnosed", "as", "having", "C0014122#ent", "<e1>", "IE", ")", "complicated", "by", "C0340375#ent", "<e2>", "DSS", ")", "."], "h": {"id": "C0014122", "name": "C0014122#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0340375", "name": "C0340375#ent", "pos": [20, 21]}}
{"token": ["We", "tested", "whether", "C0057676#ent", "<e1>", "BDM", ")", ",", "a", "reversible", "inhibitor", "of", "C0001478#ent", "<e2>", "given", "before", "coronary", "occlusion", "limits", "infarct", "size", "anesthetized", "open-chest", "dogs", "."], "h": {"id": "C0057676", "name": "C0057676#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001478", "name": "C0001478#ent", "pos": [12, 13]}}
{"token": ["Phosphoinositide", "3-kinase", "C2alpha", "C1418571#ent", "<e1>", ")", "belongs", "to", "the", "C2936441#ent", "<e2>", "which", "are", "defined", "by", "their", "in", "vitro", "of", "phosphatidylinositol", "and", "phosphatidylinositol", "4-phosphate", "substrates", "."], "h": {"id": "C1418571", "name": "C1418571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936441", "name": "C2936441#ent", "pos": [9, 10]}}
{"token": ["Serum", "albumin", "C3536873#ent", "<e1>", "chromatographed", "on", "columns", "of", "C0086140#ent", "<e2>", ",", "hyaluronate", "and", "chondroitin", "4-sulphate"], "h": {"id": "C3536873", "name": "C3536873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [8, 9]}}
{"token": ["The", "IKK", "complex", "C1417708#ent", "<e1>", "an", "important", "pathway", "implicated", "in", "the", "C0038013#ent", "<e2>", "RA", ")", "disease", "process"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [11, 12]}}
{"token": ["Human", "polymorphic", "C1706240#ent", "<e1>", "variants", "are", "associated", "with", "autoimmune", "and", "C0005943#ent", "<e2>", "alter", "the", "phenotype", "and", "function", "of", "lymphocytes", ",", "establishing", "C1706240#ent", "<e1>", "as", "an", "important", "regulator", "of", "immune", "function"], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706240", "name": "C1706240#ent", "pos": [2, 3]}}
{"token": ["The", "patient's", "father", "two", "brothers", "also", "had", "C2676232#ent", "<e1>", ",", "but", "gave", "no", "history", "of", "C0025297#ent", "<e2>", "or", "other", "neisserial", "infection"], "h": {"id": "C2676232", "name": "C2676232#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [15, 16]}}
{"token": ["The", "histopathologic", "findings", "were", "similar", "to", "ischemic", "C0035328#ent", "<e1>", "persons", "without", "C0019693#ent", "<e2>"], "h": {"id": "C0035328", "name": "C0035328#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [11, 12]}}
{"token": ["In", "mammals", ",", "four", "C0014442#ent", "<e1>", "are", "known", ":", "xanthine", "oxidoreductase", "C1412433#ent", "<e2>", "two", "recently", "described", "mouse", "proteins", "as", "aldehyde", "oxidase", "homologue", "1", "aldehyde", "oxidase", "homologue", "2"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412433", "name": "C1412433#ent", "pos": [11, 12]}}
{"token": ["Thus", "aldehyde", "dehydrogenase", "not", "the", "only", "C0014442#ent", "<e1>", "oxidising", "xenobiotic", "and", "endobiotic", "aldehydes", "the", "role", "of", "C1412433#ent", "<e2>", "such", "reactions", "should", "not", "be", "ignored", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412433", "name": "C1412433#ent", "pos": [16, 17]}}
{"token": ["Our", "data", "demonstrated", "that", "ketotifen", "was", "as", "effective", "as", "C0010620#ent", "<e1>", "in", "the", "treatment", "of", "C0042109#ent", "<e2>", "Thai", "children", "."], "h": {"id": "C0010620", "name": "C0010620#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [15, 16]}}
{"token": ["In", "addition", "the", "same", "experiment", "was", "conducted", "on", "transgenic", "mice", "which", "the", "C0022959#ent", "<e1>", "linked", "to", "the", "C0028978#ent", "<e2>", "promoter", "."], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [17, 18]}}
{"token": ["After", "administering", "sodium", "dipropylacetate", "normal", "rats", "and", "biotin-deficient", "rats", ",", "we", "observed", "a", "slight", "C0268579#ent", "<e1>", ",", "significant", "constant", "C0543541#ent", "<e2>", ",", "but", "no", "accumulation", "of", "propionic", "acid", "the", "blood", "or", "significant", "urinary", "elimination"], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0543541", "name": "C0543541#ent", "pos": [19, 20]}}
{"token": ["In", "two", "patients", "(", "11", "%", ")", ",", "C1705982#ent", "<e1>", "mutation", "was", "detected", "in", "at", "least", "one", "C0719022#ent", "<e2>", "but", "not", "in", "the", "lung", "tumour"], "h": {"id": "C1705982", "name": "C1705982#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [17, 18]}}
{"token": ["C1705982#ent", "<e1>", "mutation", "was", "detected", "in", "the", "lung", "tumour", "not", "in", "C0719022#ent", "<e2>", "four", "patients", "(", "21", "%", ")", ",", "in", "both", "the", "lung", "tumour", "C0719022#ent", "<e2>", "four", "other", "patients", "(", "21", "%", ")", "."], "h": {"id": "C1705982", "name": "C1705982#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "if", "pharmacological", "C3494348#ent", "<e1>", "attenuate", "SM-induced", "apoptosis", "via", "Bad", "dephosphorylation", "C0022575#ent", "<e2>", "were", "pretreated", "with", "the", "CaM-specific", "antagonist", "W-13", "or", "its", "less", "active", "structural", "analogue", "W-12", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022575", "name": "C0022575#ent", "pos": [12, 13]}}
{"token": ["It", "is", "concluded", "that", "the", "in", "vivo", "of", "C3494348#ent", "<e1>", "DEDTC", "and", "C0022575#ent", "<e2>", ")", "on", "the", "elimination", "rate", "of", "ATRA", "is", "qualitatively", "different", "from", "that", "expected", "from", "in", "vitro", "studies", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022575", "name": "C0022575#ent", "pos": [12, 13]}}
{"token": ["C1863512#ent", "<e1>", "gamma-degraded", "factor", "IX", ",", "C2826078#ent", "<e2>", "prothrombin", ",", "and", "protein", "C", "be", "subsequently", "activated", "by", "factor", "XIa", "Russell's", "viper", "venom", "X", "coagulant", "protein", "crude", "taipan", "snake", "venom", ",", "and", "thrombin", ",", "respectively", "."], "h": {"id": "C1863512", "name": "C1863512#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2826078", "name": "C2826078#ent", "pos": [6, 7]}}
{"token": ["Clinical", "data", "244", "probands", "with", "spinocerebellar", "types", "163", "with", "C4024710#ent", "<e1>", "LCCA", ")", ",", "and", "180", "with", "olivopontocerebellar", "atrophies", "C3811222#ent", "<e2>", ")", "were", "analysed", "."], "h": {"id": "C4024710", "name": "C4024710#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811222", "name": "C3811222#ent", "pos": [19, 20]}}
{"token": ["Point", "mutations", "deletions", "in", "the", "androgen", "receptor", "gene", "androgen", "insensitivity", "syndrome", "however", "subjects", "with", "C1839259#ent", "<e1>", "normal", "virilization", "although", "progressive", "C0018418#ent", "<e2>", ",", "testicular", "atrophy", "infertility", "may", "occur", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0018418", "name": "C0018418#ent", "pos": [20, 21]}}
{"token": ["Electrophoresis", "revealed", "the", "typical", "pattern", "for", "alkaline", "phosphatase", "isoenzymes", "observed", "in", "transient", "C0085681#ent", "<e1>", "of", "infancy", ":", "a", "fast-migrating", "liver", "isoenzyme", "and", "a", "C0297331#ent", "<e2>"], "h": {"id": "C0085681", "name": "C0085681#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0297331", "name": "C0297331#ent", "pos": [23, 24]}}
{"token": ["Oncogenic", "osteomalacia", "OOM", ")", "is", "characterised", "by", "tumour", "production", "of", "fibroblast", "growth", "factor", "23", "FGF23", ")", "that", "results", "in", "C0085682#ent", "<e1>", "and", "renal", "phosphate", "wasting", "reduced", "1,25-dihydroxyvitamin", "D3", "1,25(OH)2D3", ")", "synthesis", "and", "C0029442#ent", "<e2>", "."], "h": {"id": "C0085682", "name": "C0085682#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0029442", "name": "C0029442#ent", "pos": [32, 33]}}
{"token": ["After", "15", "days", "the", "animals", "presented", "C0085682#ent", "<e1>", ",", "rickets", "and", "C0029442#ent", "<e2>", ",", "as", "assessed", "by", "histomorphometry", "of", "the", "tibia", "and", "seventh", "caudal", "vertebra", "calcification", "fronts", "respectively", "."], "h": {"id": "C0085682", "name": "C0085682#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029442", "name": "C0029442#ent", "pos": [11, 12]}}
{"token": ["Investigations", "revealed", "C0085682#ent", "<e1>", ",", "phosphaturia", ",", "undetectable", "serum", "1,25-dihydroxyvitamin", "D", "severe", "C0029442#ent", "<e2>", "on", "bone", "biopsy", "suggestive", "of", "a", "diagnosis", "of", "oncogenic", "osteomalacia"], "h": {"id": "C0085682", "name": "C0085682#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029442", "name": "C0029442#ent", "pos": [12, 13]}}
{"token": ["Treatment", "of", "patients", "with", "triamcinolone", "decreases", "C1704964#ent", "<e1>", "levels", "in", "the", "C0271408#ent", "<e2>", ",", "with", "marked", "disease", "improvement", "."], "h": {"id": "C1704964", "name": "C1704964#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0271408", "name": "C0271408#ent", "pos": [11, 12]}}
{"token": ["Increases", "in", "body", "weight", "are", "important", ",", "and", "clinically", "significant", "adverse", "effects", "several", "C0003299#ent", "<e1>", "AED", ")", "including", "valproate", "and", "C0060926#ent", "<e2>", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [20, 21]}}
{"token": ["Medications", "with", "a", "more", "extensive", "safety", "record", "in", "pregnancy", "include", "opioids", ";", "C0003299#ent", "<e1>", ",", "such", "as", "carbamazepine", "and", "C0060926#ent", "<e2>", ";", "and", "certain", "benzodiazepines", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [12, 13]}, "relation": "therapeutic_class_of", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [19, 20]}}
{"token": ["To", "examine", "the", "clinical", "effectiveness", "cost-effectiveness", "of", "newer", "C0003299#ent", "<e1>", "AEDs", ")", "for", "epilepsy", "in", "children", ":", "C0060926#ent", "<e2>", ",", "lamotrigine", ",", "levetiracetam", ",", "oxcarbazepine", ",", "tiagabine", ",", "topiramate", "and", "vigabatrin", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [8, 9]}, "relation": "therapeutic_class_of", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [17, 18]}}
{"token": ["The", "C0031727#ent", "<e1>", "appears", "to", "be", "distinct", "from", "protein", "kinase", "C", "cAMP-dependent", "protein", "kinase", "and", "two", "C0252902#ent", "<e2>", "PAK", "II", "H4P", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0252902", "name": "C0252902#ent", "pos": [16, 17]}}
{"token": ["In", "all", "likelihood", ",", "these", "two", "subunits", "individually", "form", "cyclin-dependent", "kinase/cyclin", "dimers", "C1423887#ent", "<e1>", "a", "key", "C0014442#ent", "<e2>", "in", "phosphorylation", "of", "the", "C-terminal", "domain", "RNA", "polymerase", "II", "concomitant", "with", "transcription", "."], "h": {"id": "C1423887", "name": "C1423887#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["The", "C2917660#ent", "<e1>", "compositions", "or", "partial", "sequence", "these", "peptides", "indicated", "that", "C1825064#ent", "<e2>", "and", "lysine-96", "were", "the", "only", "dinitrophenylated", "residues", "in", "DNP1", "-", "33lysozyme", "and", "DNP1", "-", "96lysozyme", ",", "respectively", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1825064", "name": "C1825064#ent", "pos": [11, 12]}}
{"token": ["This", "study", "thus", "characterizes", "the", "regulated", "nuclear", "transport", "a", "signaling", "molecule", "response", "to", "C0026249#ent", "<e1>", "GPCR", "agonists", "and", "positions", "PKD", "as", "a", "C0072402#ent", "<e2>", "kinase", "activity", "intracellular", "localization", "is", "coordinated", "by", "PKC", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [22, 23]}}
{"token": ["C0026249#ent", "<e1>", "and", "stress-activated", "kinase-1", "MSK1", ")", "is", "a", "C0072402#ent", "<e2>", "is", "activated", "by", "either", "p38", "or", "p42ERK", "MAPKs", "in", "response", "to", "stress", "or", "mitogenic", "extracellular", "stimuli", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [9, 10]}}
{"token": ["In", "most", "cases", "a", "differentiation", "between", "primary", "humoral", "C0005818#ent", "<e1>", "a", "secondary", "bleeding", "diathesis", "to", "consumption", "C0012739#ent", "<e2>", "is", "possible", "by", "means", "of", "anamnestic", ",", "clinical", "and", "laboratory", "parameters", "."], "h": {"id": "C0005818", "name": "C0005818#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [16, 17]}}
{"token": ["In", "this", "unrandomized", ",", "open", "design", "study", "we", "used", "iontophoresis", "and", "laser", "Doppler", "flowmetry", "examine", "forearm", "skin", "perfusion", "in", "C0020443#ent", "<e1>", "patients", "with", "PAOD", "before", "and", "after", "cholesterol-lowering", "therapy", "C0246203#ent", "<e2>", "."], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0246203", "name": "C0246203#ent", "pos": [29, 30]}}
{"token": ["Patients", "with", "photosensitive", "epilepsy", "susceptible", "to", "C0751495#ent", "<e1>", "due", "to", "C1868677#ent", "<e2>", "PPR", ")", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1868677", "name": "C1868677#ent", "pos": [10, 11]}}
{"token": ["Patients", "with", "photosensitive", "epilepsy", "susceptible", "to", "C0751495#ent", "<e1>", "due", "to", "photoparoxysmal", "response", "C1868677#ent", "<e2>", ")", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1868677", "name": "C1868677#ent", "pos": [12, 13]}}
{"token": ["Urinary", "C3273436#ent", "<e1>", "levels", "in", "patients", "whose", "clinical", "feature", "C1704321#ent", "<e2>", "found", "to", "be", "higher", "than", "in", "patients", "whose", "clinical", "feature", "nephritic", "syndrome"], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [9, 10]}}
{"token": ["In", "synthetic", "liposomes", "PE", ",", "C4283796#ent", "<e1>", "and", "C3811118#ent", "<e2>", ",", "microviscosity", "decreased", "when", "the", "proportion", "of", "C4283796#ent", "<e1>", "was", "increased", "or", "the", "proportion", "of", "C3811118#ent", "<e2>", "was", "decreased", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [5, 6]}}
{"token": ["C1417664#ent", "<e1>", "is", "also", "involved", "in", "C1420369#ent", "<e2>", "integrin-", "or", "antigen", "receptor-mediated", "signaling", "B", "and", "T", "cells"], "h": {"id": "C1417664", "name": "C1417664#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [6, 7]}}
{"token": ["Hematological", "toxicity", "scores", "increased", "by", "C0020823#ent", "<e1>", ",", "Etoposide", ",", "and", "Cytarabine", "combined", "with", "C1417487#ent", "<e2>", "without", "altering", "the", "serum", "levels", "."], "h": {"id": "C0020823", "name": "C0020823#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [14, 15]}}
{"token": ["Angiotensin", "II", "receptor", "blockers", "ARBs", ")", "are", "highly", "efficacious", ",", "persistent", ",", "well-tolerated", "C0003364#ent", "<e1>", "with", "additional", "benefits", "in", "C0020538#ent", "<e2>", "CV", "pathologies", "end-organ", "damage", ",", "and", ",", "in", "diabetes", ",", "diabetic", "nephropathy", "metabolic", "syndrome"], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [19, 20]}}
{"token": ["Our", "findings", "indicate", "that", "alpha", "1-adrenoceptors", "present", "in", "the", "epidermis", ",", "and", "suggest", "that", "their", "numbers", "may", "be", "increased", "in", "the", "C0728960#ent", "<e1>", "skin", "of", "patients", "with", "C0034931#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0034931", "name": "C0034931#ent", "pos": [27, 28]}}
{"token": ["alpha", "1-Adrenoceptors", "identified", "in", "the", "epidermis", "and", "dermal", "papillae", "normal", "individuals", ",", "and", "in", "the", "C0728960#ent", "<e1>", "and", "pain-free", "skin", "of", "patients", "with", "C0034931#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0034931", "name": "C0034931#ent", "pos": [23, 24]}}
{"token": ["The", "clinical", "efficacy", "rate", "of", "C0008286#ent", "<e1>", "in", "patients", "with", "underlying", "diseases", "such", "as", "lung", "cancer", "C0041327#ent", "<e2>", "and", "pneumoconiosis", ",", "etc", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [16, 17]}}
{"token": ["The", "goals", "of", "treatment", "of", "Paget's", "disease", "be", "readdressed", "in", "the", "context", "of", "the", "availability", "of", "C0012544#ent", "<e1>", "including", "pamidronate", "and", ",", "more", "recently", ",", "alendronate", "and", "C0166025#ent", "<e2>", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [16, 17]}, "relation": "structural_class_of", "t": {"id": "C0166025", "name": "C0166025#ent", "pos": [27, 28]}}
{"token": ["SHP-1", ",", "a", "C1872758#ent", "<e1>", "selectively", "binds", "and", "dephosphorylates", "C1430988#ent", "<e2>", "in", "Src", "transfected", "cells", "."], "h": {"id": "C1872758", "name": "C1872758#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [9, 10]}}
{"token": ["It", "retained", "greater", "in", "vitro", "activity", "than", "the", "comparators", "against", "S.", "pneumoniae", "H.", "influenzae", "strains", "resistant", "to", "other", "quinolones", "due", "to", "C2917660#ent", "<e1>", "alterations", "in", "the", "quinolone", "resistance-determining", "regions", "of", "the", "target", "C1458146#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [32, 33]}}
{"token": ["Different", "fluorescence", "probes", "DPH", ",", "TMA-DPH", "and", "n-AS", ")", ",", "were", "used", "to", "determine", "the", "effect", "of", "C0021699#ent", "<e1>", "gradient", "on", "the", "lipid", "fluidity", "in", "outer", "and", "inner", "layer", "C1567357#ent", "<e2>", "SR", "vesicles", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [17, 18]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C1567357", "name": "C1567357#ent", "pos": [29, 30]}}
{"token": ["Nuclear", "translocation", "C3889135#ent", "<e1>", "is", "concurrent", "with", "the", "increase", "of", "C1522670#ent", "<e2>", "uPA", ")", "and", "the", "formation", "of", "F-actin", ",", "two", "factors", "critical", "for", "the", "migration", "of", "breast", "cancer", "cells"], "h": {"id": "C3889135", "name": "C3889135#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522670", "name": "C1522670#ent", "pos": [10, 11]}}
{"token": ["Drugs", "implicated", "in", "these", "C0012634#ent", "<e1>", "are", "the", "sulphonamides", ",", "anticonvulsants", ",", "C0002144#ent", "<e2>", ",", "pyrazolone", "derivatives", "oxicams", "and", "chlormezanone", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002144", "name": "C0002144#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "all", "the", "metal", "size-dependent", "IR", "absorptions", "are", "composed", "primarily", "of", "the", "vibrations", "of", "C3489010#ent", "<e1>", "or", "isoindole", "stretching", "breathing", "or", "deformation", "or", "aza", "stretching", "the", "C1418943#ent", "<e2>"], "h": {"id": "C3489010", "name": "C3489010#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [28, 29]}}
{"token": ["A", "familial", "form", "of", "Creutzfeldt-Jakob", "disease", "C2347435#ent", "<e1>", ")", "is", "linked", "to", "the", "D178N/V129", "prion", "protein", "(", "C1412228#ent", "<e2>", ")", "mutation", "."], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [17, 18]}}
{"token": ["C2936885#ent", "<e1>", "Pnk", "is", "a", "homotetramer", "composed", "of", "a", "C1426001#ent", "<e2>", "an", "N-terminal", "kinase", "domain"], "h": {"id": "C2936885", "name": "C2936885#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1426001", "name": "C1426001#ent", "pos": [9, 10]}}
{"token": ["Purpura", "is", "provoked", "when", "the", "affected", "area", "is", "warmed", "up", "to", "40", "degrees", "C", "by", "means", "of", "an", "infrared", "lamp", "C0010403#ent", "<e1>", "after", "exposition", "to", "cold", "with", "consecutive", "C0042109#ent", "<e2>", "."], "h": {"id": "C0010403", "name": "C0010403#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [28, 29]}}
{"token": ["C1826310#ent", "<e1>", "is", "very", "similar", "to", "C0039949#ent", "<e2>", "in", "physicochemical", "properties"], "h": {"id": "C1826310", "name": "C1826310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039949", "name": "C0039949#ent", "pos": [6, 7]}}
{"token": ["C1826310#ent", "<e1>", "then", "detoxifies", "cyanide", "again", "in", "cooperation", "with", "C0039949#ent", "<e2>", "in", "mitochondria", "."], "h": {"id": "C1826310", "name": "C1826310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039949", "name": "C0039949#ent", "pos": [9, 10]}}
{"token": ["Twenty-two", "fungal", "cultures", "grown", "from", "15", "C0795907#ent", "<e1>", "patients", "were", "studied", "for", "in", "vitro", "susceptibility", "to", "five", "common", "C0003308#ent", "<e2>", "ketoconazole", ",", "amphotericin", "B", "itraconazole", ",", "nystatin", ",", "and", "fluconazole", "."], "h": {"id": "C0795907", "name": "C0795907#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [18, 19]}}
{"token": ["It", "is", "suggested", "that", "objective", "measurement", "of", "anisocytosis", "is", "of", "early", "diagnostic", "value", "the", "assessment", "of", "multiple", "haematinic", "factor", "deficiency", "for", "example", ",", "in", "C0002886#ent", "<e1>", "associated", "with", "malabsorption", "states", "and", "unexpected", "C0268263#ent", "<e2>"], "h": {"id": "C0002886", "name": "C0002886#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0268263", "name": "C0268263#ent", "pos": [32, 33]}}
{"token": ["We", "examined", "the", "membrane", "action", "the", "endogenous", "dipeptide", "and", "putative", "neurotransmitter", "N-acetylaspartylglutamate", "(", "C0067685#ent", "<e1>", ")", "on", "the", "C0243046#ent", "<e2>", "cultured", "mouse", "spinal", "cord", "neurons", "using", "electrophysiological", "methods"], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [18, 19]}}
{"token": ["These", "data", "indicate", "that", "C0067685#ent", "<e1>", "inhibition", "may", "have", "use", "in", "neurological", "disorders", "which", "excessive", "C0243046#ent", "<e2>", "transmission", "is", "pathogenic", "."], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [15, 16]}}
{"token": ["N-Acetylated-alpha-linked", "acidic", "dipeptidase", "(", "NAALADase", ")", "is", "a", "membrane-bound", "peptidase", "hydrolyzes", "the", "endogenous", "neuropeptide", "N-acetylaspartylglutamate", "C0067685#ent", "<e1>", ")", "to", "N-acetylaspartate", "(", "NAA", ")", "and", "the", "C0243046#ent", "<e2>", "glutamate", "(", "Glu", ")", "."], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [25, 26]}}
{"token": ["Treatment", "of", "the", "isolated", "membranes", "with", "C0008354#ent", "<e1>", "or", "pertussis", "toxins", "stimulated", "the", "C1382029#ent", "<e2>", "activity", "of", "the", "membranes", ",", "but", "failed", "to", "influence", "PGE2", "binding", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [13, 14]}}
{"token": ["Interestingly", ",", "transcription", "of", "the", "C0010762#ent", "<e1>", "a", "markedly", "different", "induction", "time", "course", "the", "epoxide", "hydratase", "C1335186#ent", "<e2>"], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335186", "name": "C1335186#ent", "pos": [16, 17]}}
{"token": ["Overexpression", "of", "PKIgamma", "in", "C2C12", "cells", "was", "shown", "to", "repress", "mRNA", "expression", "of", "early", "osteoblastic", "markers", "C1424900#ent", "<e1>", "and", "type", "I", "collagen", "inhibiting", "the", "C0010531#ent", "<e2>", "activity", "."], "h": {"id": "C1424900", "name": "C1424900#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [24, 25]}}
{"token": ["C0238051#ent", "<e1>", "be", "the", "pathogenesis", "of", "the", "Landau-Kleffner", "syndrome", "calcium", "channel", "blockers", "as", "C0028005#ent", "<e2>", "may", "be", "effective", "and", "specific", "therapy", "."], "h": {"id": "C0238051", "name": "C0238051#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [13, 14]}}
{"token": ["Urinary", "volume", "24-hour", "urine", "collections", "was", "examined", "in", "50", "children", "with", "hypercalciuria", "and", "C0451641#ent", "<e1>", "or", "hematuria", ",", "12", "with", "C1833683#ent", "<e2>", "36", "healthy", "children", "."], "h": {"id": "C0451641", "name": "C0451641#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C1833683", "name": "C1833683#ent", "pos": [20, 21]}}
{"token": ["C0069562#ent", "<e1>", "treatment", "inhibited", "AGS", "cell", "proliferation", "increased", "C3470429#ent", "<e2>", ",", "Smad2/3", "phosphorylation", ",", "and", "Smad2/3-Smad4", "complex", "formation", "."], "h": {"id": "C0069562", "name": "C0069562#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [8, 9]}}
{"token": ["The", "QTL", "C1706112#ent", "<e1>", "inherited", "from", "C1823249#ent", "<e2>", "conferred", "increased", "adiposity", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1823249", "name": "C1823249#ent", "pos": [6, 7]}}
{"token": ["The", "hybridoma", "cells", "selected", "in", "C1418224#ent", "<e1>", "medium", "containing", "C0062773#ent", "<e2>", "and", "IL-6", "."], "h": {"id": "C1418224", "name": "C1418224#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [9, 10]}}
{"token": ["Croup", ",", "or", "C0010380#ent", "<e1>", ",", "is", "a", "common", "childhood", "illness", "often", "caused", "by", "C0042769#ent", "<e2>"], "h": {"id": "C0010380", "name": "C0010380#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [14, 15]}}
{"token": ["Activated", "matrix", "metalloproteinase-9", "detected", "in", "many", "vascular", "or", "C0018939#ent", "<e1>", "including", "in", "an", "experimental", "model", "C0024534#ent", "<e2>", "Plasmodium", "berghei", "ANKA"], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024534", "name": "C0024534#ent", "pos": [15, 16]}}
{"token": ["Although", "C0599295#ent", "<e1>", "steroids", "in", "C1527303#ent", "<e2>", "variable", ",", "the", "overall", "medical", "and", "cost", "benefits", "justify", "their", "early", "use", "in", "acute", "exacerbations"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1527303", "name": "C1527303#ent", "pos": [5, 6]}}
{"token": ["CDKL3", "is", "a", "member", "of", "a", "subset", "of", "the", "cdc2-related", "protein", "kinase", "family", "shows", "similarity", "to", "both", "C0169101#ent", "<e1>", "MAPK", ")", "and", "C0243045#ent", "<e2>", "cdks", ")", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [22, 23]}}
{"token": ["C2703069#ent", "<e1>", "encodes", "a", "C1366550#ent", "<e2>", "and", "Nesp", "and", "Gnasxl", "encode", "proteins", "of", "unknown", "function", "expressed", "in", "neuroendocrine", "tissue"], "h": {"id": "C2703069", "name": "C2703069#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366550", "name": "C1366550#ent", "pos": [4, 5]}}
{"token": ["The", "induction", "of", "sister-chromatid", "exchanges", "SCEs", ")", "and", "chromosomal", "aberrations", "Chinese", "hamster", "ovary", "cells", "doxorubicin", "(", "adriamycin", ")", ",", "C0102923#ent", "<e1>", "and", "several", "related", "C0003174#ent", "<e2>", "investigated", "."], "h": {"id": "C0102923", "name": "C0102923#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0003174", "name": "C0003174#ent", "pos": [24, 25]}}
{"token": ["The", "most", "active", "C0005064#ent", "<e1>", ",", "like", "lorazepam", "and", "C0040879#ent", "<e2>", ",", "act", "in", "concentrations", "of", "about", "1", "nmol/l", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C0040879", "name": "C0040879#ent", "pos": [9, 10]}}
{"token": ["The", "effect", "of", "immunosuppressive", "reagents", "cyclosporin", "A", "C1413752#ent", "<e1>", ")", "and", "rabbit", "anti-mouse", "antilymphocyte", "serum", "C1704945#ent", "<e2>", ")", "on", "the", "response", "to", "alloantigens", "was", "studied", "in", "inbred", "mouse", "strains"], "h": {"id": "C1413752", "name": "C1413752#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [15, 16]}}
{"token": ["C0024198#ent", "<e1>", "a", "controversial", "illness", ",", "and", "the", "existence", "of", "C3890422#ent", "<e2>", "induced", "by", "persistent", "infection", "with", "the", "Lyme", "spirochete", "Borrelia", "burgdorferi", "is", "the", "subject", "of", "continued", "debate", "."], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C3890422", "name": "C3890422#ent", "pos": [10, 11]}}
{"token": ["We", "therefore", "used", "multivariate", "methods", "to", "study", "the", "relationship", "between", "C1333336#ent", "<e1>", "and", "affective", "and", "C0871189#ent", "<e2>", "depressive", "disorder"], "h": {"id": "C1333336", "name": "C1333336#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0871189", "name": "C0871189#ent", "pos": [15, 16]}}
{"token": ["The", "T-ALL", "was", "C0289575#ent", "<e1>", "negative", "and", "neither", "the", "C1336596#ent", "<e2>", "nor", "the", "LYL-1", "genes", ",", "both", "situated", "at", "chromosome", "19", "p13", "were", "rearranged", "."], "h": {"id": "C0289575", "name": "C0289575#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [9, 10]}}
{"token": ["Cyclooxygenase-2", "(", "C1705323#ent", "<e1>", ")", "is", "one", "of", "the", "rate-limiting", "C0014442#ent", "<e2>", "in", "metabolism", "of", "arachidonic", "acid", "and", "COX-2", "inhibitors", "preventive", "effects", "cancer", ",", "especially", "on", "colorectal", "cancer"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["Aspirin", "(", "ASA", ")", "acetylates", "Ser516", "of", "prostaglandin", "G/H", "synthase-2", "C1705323#ent", "<e1>", ")", "resulting", "in", "a", "modified", "C0014442#ent", "<e2>", "that", "converts", "arachidonic", "acid", "15(R)-hydroxy-eicosatetraeroic", "acid", "[", "15(R)-HETE", "]", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Cyclooxygenase-2", "(", "C1705323#ent", "<e1>", ")", "is", "an", "inducible", "C0014442#ent", "<e2>", "believed", "to", "be", "responsible", "for", "prostaglandin", "synthesis", "the", "site", "of", "inflammation", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}}
{"token": ["We", "have", "studied", "the", "C1710463#ent", "<e1>", "ssrAB", "and", "the", "C2936594#ent", "<e2>", "using", "gfp", "fusions", "the", "ssrA", "and", "ssaH", "promoters", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936594", "name": "C2936594#ent", "pos": [9, 10]}}
{"token": ["The", "results", "of", "this", "retrospective", "study", "both", "C0003873#ent", "<e1>", "and", "osteoarthritis", "patients", "show", "that", "C0040377#ent", "<e2>", "was", "as", "effective", "in", "geriatric", "patients", "as", "in", "nongeriatric", "patients", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0040377", "name": "C0040377#ent", "pos": [14, 15]}}
{"token": ["v-Jun", ":", "C1333669#ent", "<e1>", "rather", "than", "v-Jun", ":", "C1705722#ent", "<e2>", "triggers", "the", "development", "of", "primary", "fibrosarcomas", "in", "the", "chicken", "wing"], "h": {"id": "C1333669", "name": "C1333669#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705722", "name": "C1705722#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "indicate", "that", "C1428360#ent", "<e1>", ",", "determined", "by", "thallium-201", "myocardial", "scintigraphy", "increases", "parallel", "to", "the", "increase", "in", "LVM", ",", "but", "unit", "C1428360#ent", "<e1>", "decreases", "even", "in", "the", "resting", "condition", "patients", "with", "C0155583#ent", "<e1>"], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [32, 33]}}
{"token": ["C1413425#ent", "<e1>", "is", "implicated", "in", "common", "C0009326#ent", "<e2>", "including", "osteoarthritis", "and", "lumbar", "disc", "disease"], "h": {"id": "C1413425", "name": "C1413425#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [6, 7]}}
{"token": ["To", "evaluate", "direct", "effects", "of", "C0041484#ent", "<e1>", "on", "mediator", "production", "induced", "by", "C2697656#ent", "<e2>", "or", "GBS", ",", "rat", "macrophages", "were", "stimulated", "with", "heat-killed", "GBS", "or", "C2697656#ent", "<e2>", "with", "or", "without", "C0041484#ent", "<e1>", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [12, 13]}}
{"token": ["Our", "objective", "is", "to", "evaluate", "the", "effectiveness", "of", "tension-free", "vaginal", "transobturator", "tapes", "(", "C1705352#ent", "<e1>", ")", "in", "the", "repair", "of", "this", "C0021167#ent", "<e2>", "."], "h": {"id": "C1705352", "name": "C1705352#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0021167", "name": "C0021167#ent", "pos": [21, 22]}}
{"token": ["We", "report", "on", "a", "7-year-old", "boy", "with", "C0023374#ent", "<e1>", "lacking", "self-mutilative", "behavior", "who", "was", "erroneously", "diagnosed", "as", "having", "C0007789#ent", "<e2>"], "h": {"id": "C0023374", "name": "C0023374#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [18, 19]}}
{"token": ["At", "C0031428#ent", "<e1>", "concentrations", "below", "250", "mg", "l(-1", ")", "a", "C0020306#ent", "<e2>", "thought", "to", "originate", "from", "the", "degradation", "of", "2,5-dimethylphenol", ",", "was", "isolated", "and", "identified", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020306", "name": "C0020306#ent", "pos": [10, 11]}}
{"token": ["C0054201#ent", "<e1>", "inhalation", "suspension", "and", "the", "leukotriene", "receptor", "antagonist", "C0298130#ent", "<e2>", "have", "demonstrated", "efficacy", "in", "children", "with", "mild", "persistent", "asthma", "but", "comparative", "long-term", "studies", "in", "young", "children", "are", "needed", "."], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0298130", "name": "C0298130#ent", "pos": [9, 10]}}
{"token": ["Using", "a", "C0035542#ent", "<e1>", "RPA", ")", ",", "we", "found", "that", "C0245109#ent", "<e2>", "mRNA", "was", "expressed", "constitutively", "in", "skin", "and", "in", "LPS-stimulated", "RAW", "264.7", "murine", "macrophages", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0245109", "name": "C0245109#ent", "pos": [10, 11]}}
{"token": ["C0016277#ent", "<e1>", "effective", "for", "the", "CNS", "manifestations", "of", "coccidioides", ",", "while", "C0019655#ent", "<e2>", "and", "blastomycoses", "typically", "require", "amphotericin", "B", "therapy"], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [11, 12]}}
{"token": ["To", "assess", "the", "effectiveness", "of", "C0016277#ent", "<e1>", "for", "suppression", "of", "relapse", "of", "C0019655#ent", "<e2>", "in", "patients", "with", "acquired", "immunodeficiency", "syndrome", "AIDS", ")", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "address", "the", "integrated", "role", "of", "ECM", "proteins", "and", "C1414463#ent", "<e1>", "in", "influencing", "breast", "cancer", "cell", "motility", "a", "mechanism", "that", "involves", "C1307053#ent", "<e2>", "and", "seems", "not", "to", "be", "related", "to", "a", "specific", "cell", "type"], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [22, 23]}}
{"token": ["However", ",", "C1414463#ent", "<e1>", "did", "prevent", "basal", "increases", "in", "STAT5", "activity", "with", "overexpressed", "C1307053#ent", "<e2>", "."], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [13, 14]}}
{"token": ["Chloramphenicol", "is", "ordinarily", "the", "C0013227#ent", "<e1>", "of", "choice", "for", "C0006105#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006105", "name": "C0006105#ent", "pos": [9, 10]}}
{"token": ["We", "also", "report", "Capnocytophaga", "spp", "resistant", "to", "metronidazole", ",", "this", "being", "the", "cause", "of", "inefficacy", "of", "this", "C0013227#ent", "<e1>", "usually", "included", "in", "empiric", "chemotherapy", "C0006105#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006105", "name": "C0006105#ent", "pos": [24, 25]}}
{"token": ["The", "phosphorylation", "level", "of", "the", "mutant", "receptor", "much", "smaller", "than", "that", "of", "the", "C1883559#ent", "<e1>", "by", "several", "C0033640#ent", "<e2>"], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "a", "45", "%", "increase", "in", "hepatic", "cAMP", "(", "relative", "to", "the", "C1883559#ent", "<e1>", "would", "be", "required", "in", "C/EBP", "beta-/-", "mice", "activate", "C0033640#ent", "<e2>", "50", "%", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [23, 24]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "the", "role", "of", "the", "membrane", "tyrosine", "phosphatase", "C1706240#ent", "<e1>", ",", "which", "regulates", "antigen", "receptor", "in", "CXCR4-mediated", "chemotaxis", "and", "C0170168#ent", "<e2>", "MAPK", ")", "activation", "in", "T-cells", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [25, 26]}}
{"token": ["Upon", "C0105421#ent", "<e1>", "stimulation", ",", "Btk", "is", "C0031727#ent", "<e2>", "at", "position", "Y551", ",", "which", "promotes", "its", "catalytic", "activity", "subsequently", "results", "in", "autophosphorylation", "at", "position", "Y223", "in", "the", "Src", "homology", "3", "domain"], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}}
{"token": ["Further", "computer", "analysis", "S.", "mansoni", "DNA", "identified", "a", "potential", "trans", "cleavage", "site", "the", "gene", "coding", "a", "C1421418#ent", "<e1>", "and", "RNA", "transcribed", "this", "C0017337#ent", "<e2>", "was", "efficiently", "cleaved", "by", "the", "Smalpha", "ribozyme", "in", "vitro"], "h": {"id": "C1421418", "name": "C1421418#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [22, 23]}}
{"token": ["We", "present", "the", "case", "of", "a", "young", "man", "with", "C1704321#ent", "<e1>", "by", "minimal", "change", "disease", "developed", "acute", "inferior", "vena", "cava", "C0238457#ent", "<e2>"], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0238457", "name": "C0238457#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "C0023835#ent", "<e1>", "metabolites", "of", "arachidonic", "acid", "a", "transient", "increase", "in", "net", "C2936886#ent", "<e2>", "content", "."], "h": {"id": "C0023835", "name": "C0023835#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "of", "vesicles", "with", "C0023835#ent", "<e1>", "for", "40", "and", "60", "min", "markedly", "depressed", "C2936886#ent", "<e2>", "accumulation", "."], "h": {"id": "C0023835", "name": "C0023835#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [13, 14]}}
{"token": ["These", "observations", "establish", "a", "role", "for", "a", "41,000-dalton", "C0043167#ent", "<e1>", "toxin", "substrate", "in", "coupling", "the", "alpha", "1-adrenergic", "receptor", "C0312059#ent", "<e2>", "hydrolysis", "in", "myocardial", "cells"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0312059", "name": "C0312059#ent", "pos": [18, 19]}}
{"token": ["These", "observations", "contrast", "with", "the", "severity", "of", "the", "C0221026#ent", "<e1>", "suggesting", "that", "C1334340#ent", "<e2>", "may", "have", "additional", "critical", "roles", "in", "lymphocyte", "survival", "V(D)J", "recombination"], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334340", "name": "C1334340#ent", "pos": [12, 13]}}
{"token": ["We", "measured", "amino", "acid", "contents", "in", "autopsied", "brains", "of", "seven", "patients", "with", "progressive", "supranuclear", "palsy", "C1332754#ent", "<e1>", ")", "and", "in", "control", "subjects", "dying", "without", "C0006111#ent", "<e2>"], "h": {"id": "C1332754", "name": "C1332754#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0006111", "name": "C0006111#ent", "pos": [24, 25]}}
{"token": ["C1968833#ent", "<e1>", "promoter", "activity", "stimulated", "by", "LPS/IFN", "was", "also", "decreased", "by", "C1414369#ent", "<e2>", "dose-dependently", "."], "h": {"id": "C1968833", "name": "C1968833#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414369", "name": "C1414369#ent", "pos": [11, 12]}}
{"token": ["C0212182#ent", "<e1>", "was", "found", "to", "counteract", "the", "locomotor", "C0002763#ent", "<e2>", "effects", "of", "the", "NMDA", "receptor", "antagonists", "MK-801", "and", "D-CPPene", ",", "but", "spontaneous", "locomotion", ",", "d-amphetamine-", "and", "GBR-12909-induced", "hyperactivity", "were", "not", "significantly", "affected", "."], "h": {"id": "C0212182", "name": "C0212182#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [8, 9]}}
{"token": ["Systemic", "corticosteroids", "been", "considered", "the", "'", "gold", "standard", "for", "the", "treatment", "of", "patients", "with", "C0085077#ent", "<e1>", "in", "addition", ",", "treatment", "with", "topical", "and/or", "C0304604#ent", "<e2>", "be", "effective", "as", "either", "monotherapy", "or", "adjuvant", "therapy"], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0304604", "name": "C0304604#ent", "pos": [23, 24]}}
{"token": ["We", "found", "that", "yeast", "cells", "C3889446#ent", "<e1>", "Ubc4", ",", "but", "not", "Ubc5", "or", "C1421281#ent", "<e2>", ",", "showed", "similar", "cadmium", "resistance", "yeast", "cells", "C3889446#ent", "<e1>", "Cdc34", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421281", "name": "C1421281#ent", "pos": [13, 14]}}
{"token": ["Our", "data", "suggest", "that", "Cbfb-MYH11", "suppressed", "C1332671#ent", "<e1>", "in", "several", "stages", "of", "T-cell", "development", "provide", "a", "mechanism", "for", "C0381246#ent", "<e2>", "association", "with", "myeloid", "but", "not", "lymphoid", "leukemia"], "h": {"id": "C1332671", "name": "C1332671#ent", "pos": [6, 7]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0381246", "name": "C0381246#ent", "pos": [18, 19]}}
{"token": ["The", "procedure", "provides", "excellent", "control", "for", "the", "symptom", "of", "C0042571#ent", "<e1>", "and", "is", "one", "of", "the", "most", "successful", "methods", "in", "the", "treatment", "of", "C0042571#ent", "<e1>", "due", "to", "C0013447#ent", "<e1>"], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013447", "name": "C0013447#ent", "pos": [27, 28]}}
{"token": ["Neurologic", "disease", "for", "C0042571#ent", "<e1>", "in", "0.14", "%", ",", "metabolic", "disease", "0.09", "%", "and", "C0013447#ent", "<e2>", "%", "."], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013447", "name": "C0013447#ent", "pos": [14, 15]}}
{"token": ["To", "characterize", "otologic", "causes", "for", "C0042571#ent", "<e1>", ",", "data", "on", "564", "patients", "with", "the", "six", "most", "common", "diseases", "involving", "C0042571#ent", "<e1>", "were", "retrieved", "from", "the", "database", "of", "a", "computer-aided", "diagnostic", "system", "C0013447#ent", "<e1>"], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013447", "name": "C0013447#ent", "pos": [31, 32]}}
{"token": ["Scores", "on", "the", "C2316212#ent", "<e1>", "showed", "significantly", "greater", "improvement", "for", "those", "in", "C1412770#ent", "<e2>", "in", "comparison", "to", "the", "Wait", "List", "to", "the", "SUPPORT", "conditions", "."], "h": {"id": "C2316212", "name": "C2316212#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412770", "name": "C1412770#ent", "pos": [12, 13]}}
{"token": ["C1412097#ent", "<e1>", "Ab-MLV", ")", "encodes", "the", "C1439337#ent", "<e2>", "induces", "transformation", "of", "immortalized", "fibroblast", "lines", "pre-B", "cells"], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1439337", "name": "C1439337#ent", "pos": [6, 7]}}
{"token": ["SE", "delta", "does", "compete", "with", "RB", "for", "binding", "to", "C1412097#ent", "<e1>", "and", "is", "fully", "capable", "of", "inhibiting", "the", "C1439337#ent", "<e2>"], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1439337", "name": "C1439337#ent", "pos": [18, 19]}}
{"token": ["Although", "the", "C1412097#ent", "<e1>", "is", "translocated", "and", "a", "new", "190", "kd", "C1439337#ent", "<e2>", "been", "identified", ",", "no", "breakpoints", "observed", "in", "the", "bcr", "(", "Ph+bcr-", "ALL", "."], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1439337", "name": "C1439337#ent", "pos": [11, 12]}}
{"token": ["Glucose-repressible", "synthesis", "of", "the", "following", "enzymes", "was", "seen", ":", "C0038615#ent", "<e1>", "succinic", ":", "cytochrome", "c", "reductase", "maltase", "(", "PNPGase", ")", ",", "C0016937#ent", "<e2>", ",", "\u03b1-galactokinase", "."], "h": {"id": "C0038615", "name": "C0038615#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016937", "name": "C0016937#ent", "pos": [21, 22]}}
{"token": ["C0027122#ent", "<e1>", "adductor", "muscles", "a", "rare", "cause", "of", "C0150055#ent", "<e2>", "soccer", "players", "."], "h": {"id": "C0027122", "name": "C0027122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0150055", "name": "C0150055#ent", "pos": [8, 9]}}
{"token": ["Fifteen", "patients", "aged", "11", "-", "17", "with", "a", "history", "of", "C0149931#ent", "<e1>", "with", "or", "without", "aura", "were", "treated", "with", "C0914729#ent", "<e2>", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0914729", "name": "C0914729#ent", "pos": [19, 20]}}
{"token": ["In", "a", "randomized", ",", "cross-over", "design", "112", "C0149931#ent", "<e1>", "treated", "two", "moderate", "or", "severe", "attacks", "with", "C0914729#ent", "<e2>", "12.5", "mg", "combined", "with", "either", "aceclofenac", "100", "mg", "or", "placebo", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0914729", "name": "C0914729#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "show", "that", "C1423887#ent", "<e1>", ",", "a", "developmentally", "regulated", "C1826636#ent", "<e2>", "selectively", "blocks", "the", "processing", "of", "pri-let-7", "miRNAs", "in", "embryonic", "cells"], "h": {"id": "C1423887", "name": "C1423887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826636", "name": "C1826636#ent", "pos": [10, 11]}}
{"token": ["The", "findings", "are", "also", "consistent", "with", "structural", "model", "the", "C1335439#ent", "<e1>", ",", "in", "which", "the", "specific", "C0950398#ent", "<e2>", "active", "site", "spatially", "separated", "from", "the", "nucleotidyl", "transferase", "site", "of", "the", "polymerase", "module"], "h": {"id": "C1335439", "name": "C1335439#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [16, 17]}}
{"token": ["Interestingly", ",", "thrombin", "counteracted", "this", "C3536710#ent", "<e1>", "inhibition", "of", "C0078956#ent", "<e2>", "and", "uPA", "expression", "and", "augmented", "the", "progestin-enhanced", "expression", "of", "PAI-1", "."], "h": {"id": "C3536710", "name": "C3536710#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [9, 10]}}
{"token": ["C0036472#ent", "<e1>", "scrub", "typhus", "a", "common", "C0311376#ent", "<e2>", "of", "rural", "Asia"], "h": {"id": "C0036472", "name": "C0036472#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0311376", "name": "C0311376#ent", "pos": [6, 7]}}
{"token": ["There", "was", "only", "a", "small", "but", "significant", "positive", "effect", "of", "the", "combined", "treatment", "with", "OB", "and", "C0009008#ent", "<e1>", "on", "the", "C0032002#ent", "<e2>", "content", "."], "h": {"id": "C0009008", "name": "C0009008#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [20, 21]}}
{"token": ["Progesterone", "and", "C0009008#ent", "<e1>", "citrate", "interfered", "with", "an", "increase", "of", "C0032002#ent", "<e2>", "by", "EB", ",", "but", "did", "not", "significantly", "affect", "the", "basal", "level", "of", "C0032002#ent", "<e2>"], "h": {"id": "C0009008", "name": "C0009008#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [10, 11]}}
{"token": ["C1412323#ent", "<e1>", "is", "a", "human", "C1135630#ent", "<e2>", "AKR", ")", "found", "to", "be", "elevated", "in", "several", "cancer", "types", "in", "precancerous", "lesions", "."], "h": {"id": "C1412323", "name": "C1412323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1135630", "name": "C1135630#ent", "pos": [5, 6]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "evaluate", "the", "possible", "relationship", "between", "CaOx", "C1420041#ent", "<e1>", "and", "tubulointerstitial", "(", "TI", ")", "damage", "in", "an", "animal", "model", "C0020500#ent", "<e2>", "."], "h": {"id": "C1420041", "name": "C1420041#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [25, 26]}}
{"token": ["The", "alpha1", "(", "catalytic", ")", "subunit", "of", "C3831543#ent", "<e1>", "AMPK", ")", "was", "identified", "as", "a", "dominant", "and", "novel", "C3539609#ent", "<e2>"], "h": {"id": "C3831543", "name": "C3831543#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539609", "name": "C3539609#ent", "pos": [18, 19]}}
{"token": ["This", "study", "aimed", "to", "assess", "the", "efficacy", "of", "C0026259#ent", "<e1>", "on", "disease", "activity", "decreasing", "relapse", "rate", "patients", "with", "C0026769#ent", "<e2>", "Iran", "."], "h": {"id": "C0026259", "name": "C0026259#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "whether", "C1412230#ent", "<e1>", "function", "is", "regulated", "through", "Rho-kinase", "after", "C2987634#ent", "<e2>", "stimulation", "in", "platelets", "."], "h": {"id": "C1412230", "name": "C1412230#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}}
{"token": ["We", "previously", "demonstrated", "that", "C1426102#ent", "<e1>", "inhibits", "the", "Rb", "growth-suppressing", "function", "by", "interfering", "with", "Rb-mediated", "C1334032#ent", "<e2>", "recruitment", "on", "E2F", "target", "gene", "promoters"], "h": {"id": "C1426102", "name": "C1426102#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [15, 16]}}
{"token": ["C1426102#ent", "<e1>", "overexpression", "activates", "DNA", "synthesis", "quiescent", "NIH-3T3", "cells", "C1334032#ent", "<e2>", "displacement", "."], "h": {"id": "C1426102", "name": "C1426102#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [9, 10]}}
{"token": ["C0008783#ent", "<e1>", "administration", "did", "not", "change", "the", "hormone", "release", "induced", "by", "C0020615#ent", "<e2>", "significantly", "enhanced", "the", "prolactin", "and", "TSH", "responses", "to", "TRH", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [11, 12]}}
{"token": ["Competition", "binding", "assays", "that", "the", "E4F", "factor", "was", "C1421297#ent", "<e1>", "specific", "and", "did", "not", "interact", "with", "any", "other", "C1709313#ent", "<e2>", "inducible", "promoter", "."], "h": {"id": "C1421297", "name": "C1421297#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [18, 19]}}
{"token": ["The", "synthetic", "progestins", "norgestimate", "and", "norelgestromin", ",", "were", "designed", "to", "minimize", "the", "adverse", "effects", "as", "C0001144#ent", "<e1>", ",", "hirsuitism", "and", "metabolic", "changes", "observed", "with", "C0009905#ent", "<e2>", "maintaining", "contraceptive", "effectiveness", "cycle", "control"], "h": {"id": "C0001144", "name": "C0001144#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0009905", "name": "C0009905#ent", "pos": [24, 25]}}
{"token": ["This", "C1412615#ent", "<e1>", "also", "activated", "by", "thiazolidinediones", ",", "a", "new", "class", "of", "C0935929#ent", "<e2>", "resulting", "in", "a", "marked", "adipogenic", "response", "in", "cultured", "cells", "enhanced", "insulin", "sensitivity", "in", "vivo"], "h": {"id": "C1412615", "name": "C1412615#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [12, 13]}}
{"token": ["Exchanging", "the", "transmembrane", "region", "the", "C0007286#ent", "<e1>", "of", "SialT2", "and", "C4283926#ent", "<e2>", "indicates", "that", "information", "for", "proximal", "or", "distal", "Golgi", "concentration", "is", "associated", "with", "C0007286#ent", "<e1>", "."], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4283926", "name": "C4283926#ent", "pos": [10, 11]}}
{"token": ["C0594375#ent", "<e1>", "and", "SN-38", "competitively", "inhibited", "C1142644#ent", "<e2>", "(", "testosterone", "6", "beta-hydroxylation", ")", "activity", "with", "K(i", ")", "values", "of", "129", "and", "121", "microM", ",", "respectively", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "C0594375#ent", "<e1>", "and", "SN-38", "were", "suggested", "to", "be", "mechanism-based", "inactivators", "of", "C1142644#ent", "<e2>", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [13, 14]}}
{"token": ["Three", "members", "of", "this", "family", "have", "been", "identified", "in", "rodents", ":", "FoxO1", ",", "FoxO3", "and", "C1704966#ent", "<e1>", ",", "originally", "termed", "C1333572#ent", "<e2>", ",", "FKHRL1", "and", "AFX", "respectively", "."], "h": {"id": "C1704966", "name": "C1704966#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333572", "name": "C1333572#ent", "pos": [20, 21]}}
{"token": ["Total", "tract", "of", "fiber", "was", "unaffected", "by", "diet", ",", "but", "total", "tract", "C0054259#ent", "<e1>", "digestibility", "increased", "from", "93.1", "to", "97.4", "%", "when", "C0220742#ent", "<e2>", "replaced", "DC", "."], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0220742", "name": "C0220742#ent", "pos": [22, 23]}}
{"token": ["Likewise", ",", "total-tract", "C0054259#ent", "<e1>", "digestibilities", "were", "similar", "between", "C0220742#ent", "<e2>", "and", "SFC", "and", "were", "3", "%", "greater", "(", "P", "<", "0.05", ")", "than", "DRC", "."], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0220742", "name": "C0220742#ent", "pos": [9, 10]}}
{"token": ["C0220754#ent", "<e1>", "characterized", "clinically", "by", "skin", "rash", "alopecia", ",", "C0036572#ent", "<e2>", "and", "ataxia", "and", "occasionally", "by", "candidiasis", "and", "developmental", "delay"], "h": {"id": "C0220754", "name": "C0220754#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}}
{"token": ["Severe", "acute", "respiratory", "syndrome", "C1419818#ent", "<e1>", ")", "is", "a", "C0035242#ent", "<e2>", "by", "a", "newly", "found", "virus", ",", "called", "C1419818#ent", "<e1>", "coronavirus", "."], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419818", "name": "C1419818#ent", "pos": [4, 5]}}
{"token": ["The", "mechanisms", "that", "mediate", "these", "C1423716#ent", "<e1>", "elevations", "in", "C0086661#ent", "<e2>", "mRNA", "levels", ",", "however", ",", "have", "not", "been", "determined", "for", "normal", "B", "T", "cells"], "h": {"id": "C1423716", "name": "C1423716#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [9, 10]}}
{"token": ["Abnormal", "left", "ventricular", "relaxation", "turned", "out", "to", "be", "a", "characteristic", "feature", "in", "patients", "with", "congestive", "cardiomyopathy", "C0026265#ent", "<e1>", "contributed", "to", "the", "generation", "of", "C0020488#ent", "<e2>", "its", "pressure", "and", "volume", "."], "h": {"id": "C0026265", "name": "C0026265#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020488", "name": "C0020488#ent", "pos": [23, 24]}}
{"token": ["It", "has", "been", "generally", "accepted", "that", "glycosylation", "of", "C2984141#ent", "<e1>", "and", "of", "other", "C2717827#ent", "<e2>", "a", "prerequisite", "for", "enzyme", "activity", "correct", "protein", "folding"], "h": {"id": "C2984141", "name": "C2984141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2717827", "name": "C2717827#ent", "pos": [13, 14]}}
{"token": ["C1710520#ent", "<e1>", "was", "expressed", "in", "all", "cells", ",", "but", "C1419420#ent", "<e2>", "was", "expressed", "weakly", "and", "only", "in", "mature", "ascospores", "."], "h": {"id": "C1710520", "name": "C1710520#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419420", "name": "C1419420#ent", "pos": [9, 10]}}
{"token": ["This", "review", "highlights", "progress", "in", "dissecting", "how", "C0028123#ent", "<e1>", "NR", ")", "activity", "is", "regulated", "by", "Ca2", "+", ",", "C0033640#ent", "<e2>", "protein", "kinase", "kinases", "protein", "phosphatases", "14", "-", "3", "-", "3", "proteins", "and", "protease(s", ")", "."], "h": {"id": "C0028123", "name": "C0028123#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [18, 19]}}
{"token": ["We", "have", "previously", "shown", "that", "genistein", "could", "inhibit", "C0164786#ent", "<e1>", "activation", "and", "down-regulate", "AR", "(", "androgen", "receptor", "and", "C1366489#ent", "<e2>", "(", "prostate-specific", "antigen", "expression", "in", "prostate", "cancer", "PCa", ")", "cells", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366489", "name": "C1366489#ent", "pos": [18, 19]}}
{"token": ["We", "now", "show", "that", "C0164786#ent", "<e1>", "activation", "and", "activity", "are", "markedly", "increased", "in", "androgen-independent", ",", "C1366489#ent", "<e2>", "LNAI", "cells", ")", "established", "from", "xenograft", "tumors", "of", "the", "androgen-dependent", "LNCaP", "cell", "line", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366489", "name": "C1366489#ent", "pos": [15, 16]}}
{"token": ["Analysis", "of", "a", "DAP-5", "full-length", "cDNA", "clone", "revealed", "that", "it", "codes", "for", "a", "97-kDa", "protein", "that", "is", "highly", "homologous", "to", "C1414356#ent", "<e1>", "eIF4G", "also", "known", "as", "C2826593#ent", "<e2>", ")", "."], "h": {"id": "C1414356", "name": "C1414356#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2826593", "name": "C2826593#ent", "pos": [26, 27]}}
{"token": ["Taken", "together", "with", "enhanced", "insulin", "secretion", "SREBP-1-null", "islets", ",", "these", "data", "suggest", "that", "C1420398#ent", "<e1>", "and", "endogenous", "lipogenesis", "could", "be", "involved", "in", "beta-cell", "dysfunction", "C0011847#ent", "<e2>", "."], "h": {"id": "C1420398", "name": "C1420398#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [24, 25]}}
{"token": ["C0151313#ent", "<e1>", "PSN", ")", "and", "C0085119#ent", "<e2>", "disabling", "and", "expensive", "complications", "of", "diabetes", "with", "few", "therapeutic", "options", "."], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085119", "name": "C0085119#ent", "pos": [5, 6]}}
{"token": ["Malondialdehyde", ",", "reduced", "glutathione", ",", "catalase", ",", "superoxide", "dismutase", "C1415326#ent", "<e1>", "peroxidase", "and", "C0040676#ent", "<e2>", "were", "determined", "in", "liver", "."], "h": {"id": "C1415326", "name": "C1415326#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040676", "name": "C0040676#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "early", "treatment", "FR167653", "effectively", "prevented", "C0178664#ent", "<e1>", "and", "renal", "dysfunction", "the", "chronic", "phase", "C0022658#ent", "<e2>"], "h": {"id": "C0178664", "name": "C0178664#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [15, 16]}}
{"token": ["Treatment", "of", "stimulated", "PBMC", "with", "the", "anti-inflammatory", "compounds", "salicylic", "acid", "5", "mm", ")", "and", "C2698196#ent", "<e1>", "(", "25", "microm", ")", "decreased", "the", "rate", "of", "C0067385#ent", "<e2>", "and", "SDMA", "formation", "."], "h": {"id": "C2698196", "name": "C2698196#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0067385", "name": "C0067385#ent", "pos": [24, 25]}}
{"token": ["Toward", "this", "goal", ",", "we", "examined", "a", "panel", "of", "somatic", "cell", "hybrids", "assigned", "the", "C0017337#ent", "<e1>", "(", "TCF12", ")", "encoding", "the", "C1420632#ent", "<e2>", "HTF4", ")", "to", "chromosome", "15"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "the", "efficiency", "of", "biofiltration", "process", "using", "C0001275#ent", "<e1>", "GAC", ")", "and", "C0303755#ent", "<e2>", "as", "the", "fillers", "was", "also", "evaluated", "through", "a", "column", "experiment", "."], "h": {"id": "C0001275", "name": "C0001275#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0303755", "name": "C0303755#ent", "pos": [13, 14]}}
{"token": ["This", "rise", "resulted", "from", "an", "accumulation", "of", "RNA", "encoding", "C1332828#ent", "<e1>", "and", "was", "associated", "with", "stimulation", "of", "C0012010#ent", "<e2>", "demethylation", "."], "h": {"id": "C1332828", "name": "C1332828#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "whether", "the", "gene", "dosage", "C1332828#ent", "<e1>", "affects", "the", "metabolism", "of", "C0012010#ent", "<e2>", "and", "desmethyldiazepam", "in", "healthy", "Chinese", "subjects", "."], "h": {"id": "C1332828", "name": "C1332828#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [12, 13]}}
{"token": ["The", "decrease", "in", "C1420175#ent", "<e1>", "and", "in", "C1334089#ent", "<e2>", "and", "insulin", "receptors", "associated", "with", "severe", "histological", "changes", "in", "the", "mandibular", "condyles", "humeral", "growth", "plate"], "h": {"id": "C1420175", "name": "C1420175#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [7, 8]}}
{"token": ["It", "was", "found", "that", "tolbutamide", "was", "not", "able", "to", "activate", "C0917783#ent", "<e1>", "when", "the", "calcium", "channel", "blocker", "C0280858#ent", "<e2>", "was", "present", "in", "the", "perfusate", "."], "h": {"id": "C0917783", "name": "C0917783#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [17, 18]}}
{"token": ["This", "study", "examined", "the", "relative", "anti-Parkinson's", "disease", "C3160718#ent", "<e1>", ")", "tremor", "potencies", "of", "C0031007#ent", "<e2>", "and", "pramipexole", "in", "people", "with", "C3160718#ent", "<e1>", ",", "using", "a", "3-month", "double-blind", "cross-over", "design", "."], "h": {"id": "C0031007", "name": "C0031007#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [7, 8]}}
{"token": ["The", "distinctive", "kinetics", "and", "localisation", "of", "TR", "alpha", "C1384510#ent", "<e1>", "expression", "suggest", "cell-", "and", "stage-specific", "functions", "for", "C0968917#ent", "<e2>", ",", "both", "individually", "and", "in", "combinations", ",", "in", "chick", "neuroretinal", "development", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0968917", "name": "C0968917#ent", "pos": [17, 18]}}
{"token": ["The", "first", "model", "(", "C0035436#ent", "<e1>", "model", ")", "looks", "at", "the", "mechanism", "of", "C0525037#ent", "<e2>", "which", "sequesters", "Mdm2", "and", "leads", "to", "stabilisation", "of", "p53", "."], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [13, 14]}}
{"token": ["The", "major", "contribution", "to", "the", "interaction", "made", "by", "the", "switch", "II", "loop", "for", "the", "ability", "of", "C1422162#ent", "<e1>", "to", "discriminate", "between", "GDP", "and", "GTP-bound", "forms", "of", "C1419257#ent", "<e2>", "."], "h": {"id": "C1422162", "name": "C1422162#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419257", "name": "C1419257#ent", "pos": [26, 27]}}
{"token": ["Because", "SK-MEL-28", "does", "not", "express", "any", "isoform", "of", "human", "C1413207#ent", "<e1>", ",", "GD3", "must", "be", "cross-presented", "by", "murine", "C1456795#ent", "<e2>", "in", "vivo"], "h": {"id": "C1413207", "name": "C1413207#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [18, 19]}}
{"token": ["Only", "recently", ",", "there", "is", "increasing", "evidence", "for", "C0175702#ent", "<e1>", "and", "NFNS", "being", "allelic", "to", "C0085113#ent", "<e2>", "in", "the", "majority", "of", "patients", "."], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085113", "name": "C0085113#ent", "pos": [15, 16]}}
{"token": ["The", "antifungals", "used", "are", "itraconazole", ",", "C0022625#ent", "<e1>", ",", "miconazole", ",", "clotrimazole", ",", "C0074391#ent", "<e2>", ",", "terbinafine", ",", "tioconazole", ",", "fluconazole", ",", "isoconazole", "and", "econazole", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0074391", "name": "C0074391#ent", "pos": [13, 14]}}
{"token": ["Both", "tea", "and", "the", "oral", "administration", "EGCG", "prevented", "the", "C1420718#ent", "<e1>", "cells", "in", "the", "substantia", "nigra", "SN", ")", "and", "of", "C4285344#ent", "<e2>", "activity", "in", "the", "striatum", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4285344", "name": "C4285344#ent", "pos": [20, 21]}}
{"token": ["Administration", "of", "nerve", "growth", "factor", "PC-G2", "causes", "a", "4-", "to", "8-fold", "induction", "in", "the", "specific", "activity", "of", "C1420718#ent", "<e1>", "tyrosine", "3-monooxygenase", "L-tyrosine", ",", "tetrahydropteridine", ":", "oxygen", "oxidoreductase(3-hydroxylating", ")", ";", "C4285344#ent", "<e2>", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4285344", "name": "C4285344#ent", "pos": [29, 30]}}
{"token": ["Expression", "of", "YFP", "under", "the", "direct", "control", "of", "the", "entire", "endogenous", "5", "'", "upstream", "region", "the", "C1420718#ent", "<e1>", "predicted", "to", "closely", "match", "expression", "of", "C4285344#ent", "<e2>", "from", "the", "wild", "type", "allele", "thus", "marking", "functional", "dopaminergic", "neurons"], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4285344", "name": "C4285344#ent", "pos": [24, 25]}}
{"token": ["Daily", "therapy", "phenobarbital", "or", "C0042291#ent", "<e1>", "reduce", "the", "number", "of", "subsequent", "simple", "C0009952#ent", "<e2>", "seizures", "."], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [12, 13]}}
{"token": ["We", "proposed", "a", "novel", "combined", "gene", "therapy", "human", "C1421446#ent", "<e1>", "hVEGF165", ")", "and", "human", "C1332424#ent", "<e2>", "hBMP2", ")", "for", "bone", "regeneration", "lentivirus-mediated", "co-transfection", "of", "both", "genes", "into", "rat", "bone", "marrow-derived", "mesenchymal", "stromal", "cells", "MSCs", ")", "."], "h": {"id": "C1421446", "name": "C1421446#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332424", "name": "C1332424#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "DA", "induces", "mitochondrial", "cytochrome", "c", ",", "which", "is", "dependent", "on", "C1120843#ent", "<e1>", "precedes", "the", "cleavage", "of", "C0534519#ent", "<e2>", "."], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "the", "apoptotic", "signaling", "pathway", "tumor", "necrosis", "factor-related", "apoptosis-inducing", "ligand", "TRAIL/Apo2L", ")", "induced", ",", "we", "investigated", "the", "contribution", "of", "reactive", "oxygen", "species", "ROS", ")", ",", "C1120843#ent", "<e1>", "MAP", ")", "kinase", "and", "C0534519#ent", "<e2>", "in", "human", "adenocarcinoma", "HeLa", "cells"], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [32, 33]}}
{"token": ["Receptors", "for", "C0042071#ent", "<e1>", "were", "evident", "on", "both", "RA", "and", "OA", "C1366480#ent", "<e2>", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366480", "name": "C1366480#ent", "pos": [11, 12]}}
{"token": ["Individuals", "infected", "with", "the", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "may", "be", "asymptomatic", "or", "have", "C0001849#ent", "<e1>", "the", "acquired", "C0001175#ent", "<e2>", "AIDS", ")", "."], "h": {"id": "C0001849", "name": "C0001849#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [20, 21]}}
{"token": ["A", "progressive", "dementing", "illness", "the", "C0001849#ent", "<e1>", "ADC", ")", "is", "the", "most", "frequent", "neurological", "complication", "the", "C0001175#ent", "<e2>"], "h": {"id": "C0001849", "name": "C0001849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [16, 17]}}
{"token": ["C0001849#ent", "<e1>", "a", "frequent", "neurological", "complication", "the", "C0001175#ent", "<e2>", "AIDS", ")", "."], "h": {"id": "C0001849", "name": "C0001849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [7, 8]}}
{"token": ["High", "doses", "C1418873#ent", "<e1>", "did", "not", "increase", "the", "release", "of", "lactate", "dehydrogenase", "the", "C0669372#ent", "<e2>", "."], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [13, 14]}}
{"token": ["This", "study", "assessed", "the", "benefit", "of", "adding", "behavioural", "modification", "to", "C0529351#ent", "<e1>", "treatment", "for", "C0878773#ent", "<e2>", "OAB", ")", "."], "h": {"id": "C0529351", "name": "C0529351#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0878773", "name": "C0878773#ent", "pos": [14, 15]}}
{"token": ["The", "recently", "approved", "agents", "(", "trospium", ",", "solifenacin", ",", "C0529351#ent", "<e1>", ")", "used", "for", "the", "treatment", "of", "C0878773#ent", "<e2>", "been", "rigorously", "evaluated", "for", "these", "effects", "."], "h": {"id": "C0529351", "name": "C0529351#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0878773", "name": "C0878773#ent", "pos": [17, 18]}}
{"token": ["While", "U.", "maydis", "wild-type", "cells", "were", "resistant", "to", "the", "C3887697#ent", "<e1>", "inhibitor", "brequinar", ",", "strains", "expressing", "the", "human", "C1333217#ent", "<e2>", "sensitive", "to", "this", "cytostatic", "drug"], "h": {"id": "C3887697", "name": "C3887697#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333217", "name": "C1333217#ent", "pos": [18, 19]}}
{"token": ["Molecular", "cloning", "mouse", "C1413036#ent", "<e1>", "identified", "2", "truncated", "variants", "(", "C1705397#ent", "<e2>", "and", "IAP-b", ")", "in", "the", "low-activity", "mice", "."], "h": {"id": "C1413036", "name": "C1413036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [10, 11]}}
{"token": ["Activities", "of", "glycerol-3-phosphate", "acyltransferase", "C0007262#ent", "<e1>", "CPT", ")", "and", "other", "C3541394#ent", "<e2>", "involved", "in", "ketone", "production", "not", "change", "with", "physiological", "state", "sheep", "differ", "markedly", "from", "rats", "in", "this", "respect", "."], "h": {"id": "C0007262", "name": "C0007262#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}}
{"token": ["C0376515#ent", "<e1>", "expression", "correlated", "significantly", "with", "the", "C1367453#ent", "<e2>", "whereas", "it", "showed", "significant", "inverse", "correlations", "with", "p53", "accumulation", "and", "the", "apoptotic", "index"], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367453", "name": "C1367453#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", "we", "provide", "evidence", "that", "C1420713#ent", "<e1>", "treatment", "significantly", "increases", "the", "binding", "of", "osteopontin", "to", "C0009325#ent", "<e2>", "."], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [17, 18]}}
{"token": ["Since", "C1420713#ent", "<e1>", "is", "known", "to", "promote", "C0009325#ent", "<e2>", "or", "collagen-fibronectin-collagen", "cross-links", ",", "the", "contraction", "of", "the", "vitreous", "in", "this", "case", "can", "be", "attributed", "to", "the", "formation", "of", "similar", "cross-links", "."], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [7, 8]}}
{"token": ["alpha(1)-AR", "stimulation", "of", "NHE1", "is", "inhibited", "by", "the", "C1259877#ent", "<e1>", "PKC", ")", "inhibitor", "calphostin", "C", "C1420234#ent", "<e2>", "activity", "is", "abolished", "by", "the", "mitogen-activated", "protein", "kinase", "MAPK", ")", "inhibitor", "PD-98059", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420234", "name": "C1420234#ent", "pos": [15, 16]}}
{"token": ["Phorbol", "ester", "activation", "C1259877#ent", "<e1>", "both", "V(max", ")", "and", "K(Na", ")", "of", "C1420234#ent", "<e2>", ",", "suggesting", "a", "multilevel", "regulatory", "mechanism", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420234", "name": "C1420234#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "the", "PKC", "(", "C1259877#ent", "<e1>", "inhibitor", "chelerythrine", "chloride", "not", "affect", "PMA-induced", "C1420234#ent", "<e2>", "promoter", "activity", "suggesting", "that", "PMA", "stimulation", "of", "the", "hNHE3", "gene", "expression", "may", "be", "PKC-independent", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420234", "name": "C1420234#ent", "pos": [13, 14]}}
{"token": ["Significant", "differences", "in", "regional", "cerebral", "blood", "flow", "rCBF", ")", "between", "the", "placebo", "and", "the", "C0015846#ent", "<e1>", "conditions", "during", "C0030193#ent", "<e2>", "and", "painful", "stimuli", "were", "identified", "using", "statistical", "parametric", "mapping"], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [18, 19]}}
{"token": ["C2981859#ent", "<e1>", "Haemophilus", "influenzae", "type", "b", "if", "shown", "to", "be", "effective", "against", "C0032285#ent", "<e2>", "in", "developing", "countries", "could", "reduce", "acute", "lower", "respiratory", "infection", "(", "ALRI", ")", "deaths", "by", "4", "%", "."], "h": {"id": "C2981859", "name": "C2981859#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}}
{"token": ["Studies", "are", "underway", "to", "assess", "C2981859#ent", "<e1>", "efficacy", "against", "invasive", "disease", "C0032285#ent", "<e2>", ",", "and", "all-cause", "mortality", "in", "developing", "countries", "and", "to", "assess", "the", "potential", "use", "of", "these", "vaccines", "in", "adults", "."], "h": {"id": "C2981859", "name": "C2981859#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [11, 12]}}
{"token": ["Haemophilus", "influenzae", "C2981859#ent", "<e1>", "very", "efficient", "against", "C0032285#ent", "<e2>", "due", "to", "this", "bacteria", "."], "h": {"id": "C2981859", "name": "C2981859#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [7, 8]}}
{"token": ["The", "C0052201#ent", "<e1>", "genotype", "yields", "poor", "predictive", "values", "screening", "for", "clinically", "defined", "C0004153#ent", "<e2>", "despite", "positive", ",", "but", "modest", "associations", "with", "plaque", "and", "coronary", "heart", "disease", "outcomes", "."], "h": {"id": "C0052201", "name": "C0052201#ent", "pos": [1, 2]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "impact", "that", "C0056170#ent", "<e1>", "on", "the", "DNA", "damage", "response", "C1333206#ent", "<e2>", ")", "has", "not", "directly", "been", "tested", "and", "thus", "remains", "speculative", "."], "h": {"id": "C0056170", "name": "C0056170#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333206", "name": "C1333206#ent", "pos": [12, 13]}}
{"token": ["The", "same", "amount", "of", "niridazole", ",", "C0022060#ent", "<e1>", ",", "DA", "3851", "and", "C0029274#ent", "<e2>", "led", "to", "falls", "of", "less", "than", "20", "%", "in", "the", "oxygen", "uptake", "whilst", "metronidazole", "was", "ineffective", "."], "h": {"id": "C0022060", "name": "C0022060#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029274", "name": "C0029274#ent", "pos": [12, 13]}}
{"token": ["C2936550#ent", "<e1>", "biphasic", "effects", "activity", ",", "decreases", "in", "operant", "response", ",", "and", "C0003286#ent", "<e2>"], "h": {"id": "C2936550", "name": "C2936550#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [12, 13]}}
{"token": ["Acetazolamide", ",", "a", "carbonic", "anhydrase", "inhibitor", "is", "used", "in", "patients", "with", "chronic", "obstructive", "pulmonary", "diseases", "C3887547#ent", "<e1>", "in", "the", "prevention", "and", "treatment", "of", "the", "symptoms", "of", "C0238284#ent", "<e2>"], "h": {"id": "C3887547", "name": "C3887547#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0238284", "name": "C0238284#ent", "pos": [26, 27]}}
{"token": ["Results", "of", "this", "study", "should", "prove", "useful", "in", "guiding", "the", "clinical", "application", "these", "novel", "C0035064#ent", "<e1>", "in", "the", "treatment", "of", "C0812385#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [20, 21]}}
{"token": ["Herbimycin", "A", "tyrphostins", "have", "been", "found", "and", "developed", "as", "inhibitors", "of", "tyrosine", "kinases", "the", "effectiveness", "of", "these", "C0035064#ent", "<e1>", "against", "tumors", "of", "Ph1-positive", "leukemia", "CML", ",", "C0812385#ent", "<e2>", ")", "or", "squamous", "cell", "carcinomas", "been", "reported", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [26, 27]}}
{"token": ["Thus", ",", "VP", "plus", "one", "of", "these", "C0035064#ent", "<e1>", "seemed", "to", "be", "a", "recommendable", "inductive", "chemotherapy", "C0812385#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [16, 17]}}
{"token": ["Administration", "of", "clofibric", "acid", "C0076648#ent", "<e1>", "to", "female", "rats", "increased", "greatly", "the", "hepatic", "activity", "C1419846#ent", "<e2>", "the", "extent", "of", "the", "increases", "being", "slightly", "less", "pronounced", "than", "those", "of", "male", "rats", "."], "h": {"id": "C0076648", "name": "C0076648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419846", "name": "C1419846#ent", "pos": [14, 15]}}
{"token": ["The", "key", "to", "diagnosis", "is", "maintaining", "a", "high", "index", "suspicion", "for", "C0041323#ent", "<e1>", ",", "especially", "in", "patients", "with", "advanced", "C0343755#ent", "<e2>", "including", "appropriate", "laboratory", "examinations", "the", "evaluations", "of", "such", "persons", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0343755", "name": "C0343755#ent", "pos": [19, 20]}}
{"token": ["As", "no", "therapy", "available", "in", "this", "syndrome", "to", "date", ",", "our", "data", "suggest", "the", "therapeutic", "use", "of", "C3540800#ent", "<e1>", "in", "order", "to", "improve", "these", "cytoskeleton-mediated", "functions", "the", "degree", "of", "C0027947#ent", "<e2>", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [29, 30]}}
{"token": ["As", "observed", "for", "combretastatin", "A-4", "the", "sodium", "salt", "1b", ")", ",", "potassium", "salt", "1c", ")", "and", "C0075429#ent", "<e1>", "1e", ")", "derivatives", "of", "C0031428#ent", "<e2>", "essentially", "insoluble", "in", "water", "."], "h": {"id": "C0075429", "name": "C0075429#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [22, 23]}}
{"token": ["To", "illustrate", "the", "method", ",", "it", "is", "applied", "to", "two", "specific", "diseases", ",", "C0011854#ent", "<e1>", "IDDM", ")", "and", "gluten-sensitive", "enteropathy", "C1332802#ent", "<e2>", ")", ",", "and", "a", "specific", "locus", ",", "the", "HLA", "gene", "complex"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332802", "name": "C1332802#ent", "pos": [20, 21]}}
{"token": ["The", "identification", "of", "the", "yeast", "genes", "C1413100#ent", "<e1>", "and", "SAM1", ",", "which", "encode", "AdoMet", "synthase", "as", "C1333213#ent", "<e2>", "suppressors", "suggests", "that", "Abd1p", "function", "can", "be", "modulated", "by", "changes", "in", "the", "concentration", "of", "its", "substrate", "AdoMet"], "h": {"id": "C1413100", "name": "C1413100#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333213", "name": "C1333213#ent", "pos": [16, 17]}}
{"token": ["Surprisingly", ",", "PDGFR-induced", "actin", "remodeling", "in", "NIH3T3", "cells", "is", "blocked", "in", "the", "absence", "of", "C1426499#ent", "<e1>", ",", "and", "the", "cells", "are", "partially", "transformed", "via", "C0669365#ent", "<e2>", "activation", "of", "Rho", "."], "h": {"id": "C1426499", "name": "C1426499#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}}
{"token": ["Through", "proteolysis", "and", "C0030956#ent", "<e1>", "determination", "using", "mass", "spectrometry", "a", "peptide", "mass", "map", "(", "C0070302#ent", "<e2>", ")", "can", "be", "generated", "for", "protein", "identification"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0070302", "name": "C0070302#ent", "pos": [14, 15]}}
{"token": ["Fast", ",", "reproducible", ",", "and", "efficient", "separations", "of", "proteins", "and", "C0030956#ent", "<e1>", "were", "demonstrated", "using", "the", "PEG-grafted", "C0070302#ent", "<e2>", "muCE", "chips", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0070302", "name": "C0070302#ent", "pos": [17, 18]}}
{"token": ["The", "acrylamide", "group", "can", "be", "used", "to", "bind", "the", "C0030956#ent", "<e1>", "covalently", "to", "poly(methyl", "methacrylate)", "C0070302#ent", "<e2>", ")", "surfaces", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0070302", "name": "C0070302#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", "we", "compare", "the", "impact", "of", "different", "antihypertensive", "medicaments", "the", "renin-angiotensin-aldosterone", "system", "patients", "with", "C0085580#ent", "<e1>", "are", "screened", "for", "C0221043#ent", "<e2>"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0221043", "name": "C0221043#ent", "pos": [21, 22]}}
{"token": ["This", "results", "in", "a", "decline", "in", "plasma", "aldosterone", "concentrations", "in", "normal", "subjects", "C0085580#ent", "<e1>", "EH", ")", "patients", ",", "but", "not", "in", "patients", "with", "C0221043#ent", "<e2>"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0221043", "name": "C0221043#ent", "pos": [23, 24]}}
{"token": ["Western", "blotting", "with", "functional", "experiments", "have", "shown", "that", "intact", "C1418440#ent", "<e1>", "levels", "were", "required", "for", "preconditioning-induced", "phosphorylation", "of", "C0285558#ent", "<e2>", "PKB", ")", ",", "glycogen", "synthase", "kinase-3beta", "GSK-3beta", ")", ",", "and", "cardioprotection", "."], "h": {"id": "C1418440", "name": "C1418440#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [18, 19]}}
{"token": ["Tamm-Horsfall", "glycoprotein", "C1421351#ent", "<e1>", ")", ",", "produced", "exclusively", "by", "renal", "cells", "the", "thick", "ascending", "C0030196#ent", "<e2>", "of", "Henle's", "loop", "is", "attached", "by", "a", "glycosyl-phosphatidylinositol", "(GPI)-anchor", "to", "the", "luminal", "face", "of", "the", "cells", "."], "h": {"id": "C1421351", "name": "C1421351#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [14, 15]}}
{"token": ["C1421351#ent", "<e1>", "identified", "associated", "with", "the", "cells", "of", "the", "ascending", "C0030196#ent", "<e2>", "of", "the", "loop", "of", "Henle", "and", "the", "distal", "convoluted", "tubule"], "h": {"id": "C1421351", "name": "C1421351#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [10, 11]}}
{"token": ["Specific", "gene", "expression", "were", "obtained", ",", "and", "known", "markers", "(", "e.g.", ",", "C1421351#ent", "<e1>", "in", "the", "thick", "ascending", "C0030196#ent", "<e2>", "of", "Henle's", "loop", "aquaporin-2", "in", "the", "collecting", "duct", ")", "were", "found", "appropriately", "enriched", "."], "h": {"id": "C1421351", "name": "C1421351#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [18, 19]}}
{"token": ["Echovirus", "type", "12", "EV12", ")", ",", "an", "C0014378#ent", "<e1>", "of", "the", "Picornaviridae", "family", "uses", "the", "C1824670#ent", "<e2>", "DAF", ",", "CD55", ")", "as", "a", "cellular", "receptor"], "h": {"id": "C0014378", "name": "C0014378#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824670", "name": "C1824670#ent", "pos": [15, 16]}}
{"token": ["C0001942#ent", "<e1>", "been", "studied", "by", "electronic", "absorption", "C2348923#ent", "<e2>", "and", "EPR", "spectroscopy", "the", "presence", "and", "absence", "of", "coenzyme", "."], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2348923", "name": "C2348923#ent", "pos": [7, 8]}}
{"token": ["To", "determine", "if", "C0034063#ent", "<e1>", "EF", ")", "alters", "ion", "and", "fluid", "transport", "distal", "lung", "epithelium", "C0024138#ent", "<e2>", ")", ",", "EF", "was", "collected", "from", "rats", "in", "acute", "heart", "failure"], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [15, 16]}}
{"token": ["C0012963#ent", "<e1>", "produced", "a", "dose-dependent", "increase", "in", "cardiac", "cyclic", "AMP", "%", "C0017916#ent", "<e2>", "a", "and", "contractile", "force", "the", "isolated", "perfused", "rat", "heart", "."], "h": {"id": "C0012963", "name": "C0012963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017916", "name": "C0017916#ent", "pos": [11, 12]}}
{"token": ["We", "have", "isolated", "seven", "C0017337#ent", "<e1>", "that", "in", "high", "dosage", "suppress", "the", "growth", "defect", "C0081947#ent", "<e2>", "-", "1N", "cells", "but", "not", "of", "Start-defective", "cdc28", "-", "4", "cells", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0081947", "name": "C0081947#ent", "pos": [14, 15]}}
{"token": ["1", ")", "Oxytocin", "increased", "the", "C1704947#ent", "<e1>", "when", "either", "serosal", "bicarbonate", "C0041175#ent", "<e2>", "used", "and", "even", "in", "the", "presence", "of", "a", "low", "mucosal", "pH", "Tris", "buffer", "pH", "5.8", ")", "."], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041175", "name": "C0041175#ent", "pos": [11, 12]}}
{"token": ["Color", "development", "the", "Pi", "assay", "significantly", "inhibited", "by", "C0719425#ent", "<e1>", "and", "by", "greater", "than", "0.3", "mmol", "of", "C0040900#ent", "<e2>", "greater", "than", "1.5", "mumol", "of", "CAP", "."], "h": {"id": "C0719425", "name": "C0719425#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0040900", "name": "C0040900#ent", "pos": [17, 18]}}
{"token": ["Cytochrome", "P-450(CYP)1A1", "CYP2E1", ",", "glutathione", "S-transferase", "(GST)M1", "C1447799#ent", "<e1>", "polymorphisms", "and", "myeloperoxidase", "(", "MPO", ")", "and", "C1743497#ent", "<e2>", "MnSOD", ")", "polymorphisms", "were", "evaluated", "to", "determine", "the", "effect", "of", "genetic", "modification", "urinary", "8-OH-dG", "and", "MDA", "."], "h": {"id": "C1447799", "name": "C1447799#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [16, 17]}}
{"token": ["C0771315#ent", "<e1>", "inhibits", "H+,K+-ATPase", ",", "the", "C0027203#ent", "<e2>", "responsible", "for", "the", "exchange", "of", "H+", "and", "K+", "in", "the", "final", "step", "in", "the", "acid", "secretory", "process", "the", "parietal", "cell"], "h": {"id": "C0771315", "name": "C0771315#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}}
{"token": ["C0771315#ent", "<e1>", "is", "thus", "activated", "close", "to", "its", "target", "C0027203#ent", "<e2>", ",", "where", "it", "is", "present", "in", "high", "concentrations", "and", "binds", "selectively", "to", "the", "gastric", "H+,K+-ATPase"], "h": {"id": "C0771315", "name": "C0771315#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["Previously", ",", "we", "demonstrated", "that", "C1334092#ent", "<e1>", "is", "identical", "to", "a", "liver-specific", "C1414413#ent", "<e2>", "."], "h": {"id": "C1334092", "name": "C1334092#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414413", "name": "C1414413#ent", "pos": [12, 13]}}
{"token": ["We", "report", "here", "that", "one", "of", "the", "ORFs", "upstream", "from", "sodA", "is", "fumC", ",", "which", "encodes", "the", "O2.-", "resistant", "C0597298#ent", "<e1>", "of", "fumarase", "(", "or", "C1366530#ent", "<e2>", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1366530", "name": "C1366530#ent", "pos": [25, 26]}}
{"token": ["Therefore", ",", "we", "have", "studied", "the", "effects", "of", "C3540783#ent", "<e1>", "and", "other", "PPARalpha", "agonists", "on", "the", "expression", "of", "C1442762#ent", "<e2>", "."], "h": {"id": "C3540783", "name": "C3540783#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1442762", "name": "C1442762#ent", "pos": [18, 19]}}
{"token": ["The", "C0002170#ent", "<e1>", "was", "of", "non-scarry", "variety", "and", "responded", "to", "systemic", "and", "C0038317#ent", "<e2>"], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [12, 13]}}
{"token": ["However", ",", "we", "recently", "observed", "that", "C0046563#ent", "<e1>", "elevated", "the", "activity", "of", "an", "aryl", "hydrocarbon", "receptor", "C1706481#ent", "<e2>", ")", "response", "element", "luciferase", "reporter", "human", "colon", "carcinoma", "cells", "Caco-2", ")", "."], "h": {"id": "C0046563", "name": "C0046563#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706481", "name": "C1706481#ent", "pos": [16, 17]}}
{"token": ["The", "implications", "may", "be", "considerable", "for", "the", "understanding", "of", "basic", "cellular", "processes", "as", "migration", "and", "also", "of", "C0029896#ent", "<e1>", "related", "to", "loss", "or", "mutation", "of", "a", "single", "C1540081#ent", "<e2>", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1540081", "name": "C1540081#ent", "pos": [27, 28]}}
{"token": ["The", "latter", "included", "18", "individuals", "with", "C1258104#ent", "<e1>", "12", "with", "the", "CREST", "syndrome", "a", "variant", "form", "of", "C0036421#ent", "<e2>", "which", "there", "is", "more", "limited", "involvement", "of", "the", "skin", "."], "h": {"id": "C1258104", "name": "C1258104#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [17, 18]}}
{"token": ["One", "such", "C1875400#ent", "<e1>", "contained", "a", "1287-bp", "insert", "(", "C3889123#ent", "<e2>", "cDNA", ")", "which", "hybridizes", "to", "1.25-", "to", "1.35-kb", "mRNA", "species", "from", "Rp", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889123", "name": "C3889123#ent", "pos": [9, 10]}}
{"token": ["Tyrosine-phosphorylated", "C0128818#ent", "<e1>", "was", "detectable", "only", "in", "the", "presence", "of", "the", "tyrosine", "phosphatase", "vanadate", ",", "suggesting", "that", "a", "coordinated", "balance", "between", "C0211705#ent", "<e2>", "and", "phosphatase", "activities", "the", "steady-state", "level", "of", "C0128818#ent", "<e1>", "phosphorylation", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0128818", "name": "C0128818#ent", "pos": [1, 2]}}
{"token": ["Low", "molecular", "weight", "C0054452#ent", "<e1>", "may", "be", "more", "effective", "in", "the", "treatment", "of", "C0149871#ent", "<e2>", "unfractionated", "heparin", "."], "h": {"id": "C0054452", "name": "C0054452#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [13, 14]}}
{"token": ["In", "a", "prospective", ",", "randomized", "multicentre", "trial", "efficacy", "and", "safety", "of", "the", "low", "molecular", "weight", "heparin", "LMWH", ")", "fraction", "Fraxiparin", "and", "unfractionated", "C0054452#ent", "<e1>", "Calciparin", ")", "were", "compared", "for", "the", "prevention", "of", "postoperative", "C0149871#ent", "<e2>"], "h": {"id": "C0054452", "name": "C0054452#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [33, 34]}}
{"token": ["This", "was", "done", "by", "using", "heterologous", "photorepair", ";", "recombinant", "adenovirus", "vectors", "photolyases", "C3540790#ent", "<e1>", "that", "repair", "C1424987#ent", "<e2>", "or", "6", "-", "4PP", "specifically", "by", "using", "the", "energy", "of", "light", "introduced", "in", "different", "cell", "lines"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1424987", "name": "C1424987#ent", "pos": [16, 17]}}
{"token": ["Inflammatory", "pathways", "promote", "extracellular", "matrix", "C3889469#ent", "<e1>", ")", "remodeling", "and", "C0018802#ent", "<e2>", "CHF", ")", "progression", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}}
{"token": ["Some", "non-infectious", "diseases", "mimic", "C0039007#ent", "<e1>", "such", "as", "venous", "thrombosis", "C1417104#ent", "<e2>", "prosthesis", "intolerance", ",", "and", "compartment", "syndrome"], "h": {"id": "C0039007", "name": "C0039007#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417104", "name": "C1417104#ent", "pos": [10, 11]}}
{"token": ["LY294002", ",", "an", "inhibitor", "of", "C1705325#ent", "<e1>", "abolished", "expression", "of", "C1705316#ent", "<e2>", "mRNA", "and", "protein", "expression", "abolished", "C1705316#ent", "<e2>", "activity", ",", "whereas", "PD98059", ",", "which", "inhibits", "MEK1/2", "and", "thus", "ERK1/2", ",", "had", "no", "effect"], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", "the", "applicability", "of", "the", "C1332802#ent", "<e1>", "was", "extended", "to", "weak", "C3536863#ent", "<e2>", "."], "h": {"id": "C1332802", "name": "C1332802#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [13, 14]}}
{"token": ["A", "mutation", "that", "C2712370#ent", "<e1>", "the", "initiation", "codon", "of", "the", "C1367578#ent", "<e2>", "the", "human", "immunodeficiency", "virus", "the", "virus", "replication", "defective", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367578", "name": "C1367578#ent", "pos": [10, 11]}}
{"token": ["Under", "these", "incubation", "conditions", ",", "the", "mineralocorticoid", "aldosterone", "in", "the", "presence", "of", "RU", "486", ";", "also", "produced", "a", "stimulatory", "effect", "on", "C1414571#ent", "<e1>", "splenic", "lymphocyte", "mitogenesis", "whereas", "RU", "C0626723#ent", "<e2>", "was", "not", "effective", "."], "h": {"id": "C1414571", "name": "C1414571#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0626723", "name": "C0626723#ent", "pos": [28, 29]}}
{"token": ["Mannitol", "increased", "C1413682#ent", "<e1>", "in", "89", "%", "of", "occasions", "and", "C0936073#ent", "<e2>", "in", "only", "54", "%", "(", "p", "<", "0.001", ")", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [10, 11]}}
{"token": ["Neither", "trazodone", ",", "nor", "C1413682#ent", "<e1>", "changed", "the", "cerebral", "concentrations", "C0936073#ent", "<e2>", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [10, 11]}}
{"token": ["Interestingly", ",", "the", "E3", "activity", "of", "C-terminal", "point", "mutants", "MDM2", "can", "also", "be", "supported", "by", "interaction", "with", "C2987364#ent", "<e1>", "C2981745#ent", "<e2>", ",", "suggesting", "that", "C2981745#ent", "<e2>", "can", "directly", "contribute", "to", "E3", "function"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2981745", "name": "C2981745#ent", "pos": [19, 20]}}
{"token": ["The", "S367A", "mutant", "is", "more", "resistant", "to", "Mdm2-dependent", "ubiquitination", "and", "degradation", "than", "C2987364#ent", "<e1>", "C2981745#ent", "<e2>", ",", "and", "C2981745#ent", "<e2>", "phosphorylated", "at", "S367", "is", "preferentially", "degraded", "by", "Mdm2", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2981745", "name": "C2981745#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "D361A-MDMX", "mutant", "lacks", "the", "ability", "to", "inhibit", "p53", "transactivation", "respect", "to", "C2987364#ent", "<e1>", "C2981745#ent", "<e2>", ",", "suggesting", "that", "C2981745#ent", "<e2>", "caspase", "cleavage", "play", "an", "important", "functional", "role", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2981745", "name": "C2981745#ent", "pos": [17, 18]}}
{"token": ["On", "paraffin", "section", "immunochemistry", "the", "large", "lymphoid", "cells", "expressed", "C1870006#ent", "<e1>", "and", "CD45RO", ",", "but", "not", "CD43", "or", "C1417326#ent", "<e2>", "."], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417326", "name": "C1417326#ent", "pos": [18, 19]}}
{"token": ["The", "positions", "of", "nucleotide", "258", "700", "of", "cDNA", "from", "A", "C0040676#ent", "<e1>", "were", "used", "to", "distinguish", "A", ",", "B", ",", "and", "C0002085#ent", "<e2>", "restriction", "enzyme", "digestion"], "h": {"id": "C0040676", "name": "C0040676#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [21, 22]}}
{"token": ["Cells", "from", "hypertensive", "animals", "were", "more", "responsive", "to", "a", "number", "of", "C0243192#ent", "<e1>", ",", "as", "assessed", "by", "activation", "of", "C0073337#ent", "<e2>", "elevation", "of", "intracellular", "pH", "than", "those", "derived", "from", "WKY", "animals", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0073337", "name": "C0073337#ent", "pos": [19, 20]}}
{"token": ["The", "protective", "effect", "C1411980#ent", "<e1>", "also", "associated", "with", "increased", "CD40L", "and", "C1705969#ent", "<e2>", "expressing", "Th", "cells", "with", "the", "generation", "of", "a", "CD40-", "IgG+", "B", "cells", "."], "h": {"id": "C1411980", "name": "C1411980#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [11, 12]}}
{"token": ["The", "liquid", "chromatography-mass", "spectrometry/mass", "spectrometry", "LC-MS/MS", ")", "system", "identified", "the", "C0015230#ent", "<e1>", "as", "alpha-enolase", ",", "glyceraldehyde-3-phosphate", "dehydrogenase", "GAPDH", ")", ",", "triosephosphate", "isomerase", "C1420578#ent", "<e2>", ",", "calmodulin", ",", "superoxide", "dismutase(Mn", ")", "mitochondrial", "precursor", "glutathione", "S-transferase", "P", "cyclophilin", "A", "protein", "disulfide", "isomerase", "A3", "precursor", "and", "apolipoprotein", "A-I", "precursor"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420578", "name": "C1420578#ent", "pos": [22, 23]}}
{"token": ["Our", "study", "indicates", "that", "17beta-oestradiol", "can", "regulate", "Ca2", "+", "influx", "via", "C2713509#ent", "<e1>", ",", "NOS", "and", "C4084713#ent", "<e2>", "after", "activation", "of", "cytoplasmic", "ER", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4084713", "name": "C4084713#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "the", "amino-terminal", "amino", "acid", "sequence", "C1705456#ent", "<e1>", "was", "identical", "to", "that", "of", "C0667830#ent", "<e2>", ",", "and", "the", "amino-terminal", "sequence", "of", "SAP5", "was", "identical", "to", "that", "of", "SAP6", "."], "h": {"id": "C1705456", "name": "C1705456#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0667830", "name": "C0667830#ent", "pos": [15, 16]}}
{"token": ["We", "have", "previously", "shown", "that", "TLR4-deficient", "mice", "rapidly", "develop", "C0740766#ent", "<e1>", "inoculation", "with", "Bordetella", "bronchiseptica", "suggesting", "that", "C1705581#ent", "<e2>", "is", "required", "for", "expression", "of", "early", "elicited", "gene", "products", "this", "model", "."], "h": {"id": "C0740766", "name": "C0740766#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705581", "name": "C1705581#ent", "pos": [17, 18]}}
{"token": ["Patients", "were", "studied", "for", "a", "maximum", "of", "ten", "attacks", "and", "significant", "improvement", "was", "observed", "in", "the", "severity", "and", "duration", "of", "C0018681#ent", "<e1>", "when", "the", "patients", "were", "on", "C0546873#ent", "<e2>"], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [20, 21]}, "relation": "may_be_treated_by", "t": {"id": "C0546873", "name": "C0546873#ent", "pos": [27, 28]}}
{"token": ["Here", ",", "we", "report", "that", "Cdc6", "protein", "activate", "p21-associated", "C0108855#ent", "<e1>", "in", "an", "C0101555#ent", "<e2>", "manner", "in", "vitro"], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [13, 14]}}
{"token": ["Computed", "tomography", "used", "to", "exclude", "osteoarthritis", "of", "the", "zygapophyseal", "joints", "Baastrup", "'s", "disease", "(", "C0158248#ent", "<e1>", "and", "other", "sources", "of", "C0024031#ent", "<e2>"], "h": {"id": "C0158248", "name": "C0158248#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [20, 21]}}
{"token": ["Nonetheless", ",", "the", "reduced", "microbicidal", "activity", "of", "C0391448#ent", "<e1>", "against", "NNRTI-resistant", "HIV-1", "suggests", "that", "additional", "C0003451#ent", "<e2>", "be", "included", "in", "NNRTI-based", "microbicide", "formulations", "."], "h": {"id": "C0391448", "name": "C0391448#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [15, 16]}}
{"token": ["Effects", "of", "differentiating", "C0991617#ent", "<e1>", "and", "DNA", "demethylating", "agents", "the", "expression", "of", "C4082365#ent", "<e2>", "ChAT", ")", "and", "tyrosine", "hydroxylase", "TH", ")", ",", "marker", "enzymes", "for", "cholinergic", "and", "adrenergic", "differentiation", "respectively", ",", "were", "examined", "in", "N-18", "neuroblastoma", "cells"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4082365", "name": "C4082365#ent", "pos": [12, 13]}}
{"token": ["Hep", "is", "L-glycero-D-manno-heptose", ",", "QuiN", "is", "2-amino-2,6-dideoxy-D-glucose", ",", "GlcN", "is", "C0017718#ent", "<e1>", ",", "Glc", "is", "D-glucose", ",", "C1823902#ent", "<e2>", "is", "D-fructose", ",", "and", "Kdo", "is", "3-deoxy-D-manno-2-octulosonic", "acid"], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1823902", "name": "C1823902#ent", "pos": [17, 18]}}
{"token": ["Interactions", "between", "either", "the", "C0003693#ent", "<e1>", "5-LO", ")", "and", "15-LO", "or", "5-LO", "and", "C3539672#ent", "<e2>", "can", "lead", "to", "the", "formation", "of", "lipoxins", "."], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539672", "name": "C3539672#ent", "pos": [13, 14]}}
{"token": ["C0054549#ent", "<e1>", "another", "serine/threonine", "phosphatase", "inhibitor", "also", "reduced", "acetyl-LDL", "binding", "whereas", "lithium", "chloride", "an", "C0088353#ent", "<e2>", "inhibitor", ",", "did", "not", "."], "h": {"id": "C0054549", "name": "C0054549#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0088353", "name": "C0088353#ent", "pos": [14, 15]}}
{"token": ["C0016967#ent", "<e1>", "is", "a", "novel", "treatment", "for", "C0002395#ent", "<e2>", "a", "dual", "mode", "action", "."], "h": {"id": "C0016967", "name": "C0016967#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [7, 8]}}
{"token": ["The", "authors", "explored", "the", "effect", "of", "C0016967#ent", "<e1>", "on", "behavioral", "symptoms", "in", "C0002395#ent", "<e2>", "AD", ")", "."], "h": {"id": "C0016967", "name": "C0016967#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [12, 13]}}
{"token": ["This", "study", "evaluated", "daily-life", "physical", "and", "mental", "triggers", "C0239377#ent", "<e1>", "and", "painless", "C0151744#ent", "<e2>", "of", "anginal", "pain", "patients", "with", "coronary", "artery", "disease", "CAD", ")", "by", "using", "ambulatory", "electrocardiographic", "monitoring", "a", "structured", "diary", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [12, 13]}}
{"token": ["However", ",", "C0014027#ent", "<e1>", "was", "not", "taken", "up", "by", "C1420131#ent", "<e2>", "nor", "by", "the", "human", "OATP", "expressed", "in", "recombinant", "vaccinia", "systems"], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420131", "name": "C1420131#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "despite", "the", "presence", "of", "three", "closely", "related", "C1426035#ent", "<e1>", "the", "mouse", "genome", ",", "C1433154#ent", "<e2>", "is", "the", "primary", "one", "used", "in", "HS", "biosynthesis", "most", "tissues", "."], "h": {"id": "C1426035", "name": "C1426035#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1433154", "name": "C1433154#ent", "pos": [15, 16]}}
{"token": ["The", "effect", "of", "CNP", "is", "mediated", "via", "C1334895#ent", "<e1>", "causing", "elevation", "of", "intracellular", "cyclic", "GMP", "which", "possibly", "activates", "C0010536#ent", "<e2>", "causes", "attenuation", "of", "myofilament", "sensitivity", "to", "Ca2", "+", "."], "h": {"id": "C1334895", "name": "C1334895#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [18, 19]}}
{"token": ["A", "real-time", "polymerase", "chain", "reaction", "analysis", "10", "C0017337#ent", "<e1>", "in", "the", "one-carbon", "metabolism", "pathway", "that", "5,10-methylenetetrahydrofolate", "reductase", "S-adenosylhomocysteine", "hydrolase", "C3887563#ent", "<e2>", ")", ",", "and", "formiminotransferase", "cyclodeaminase", "Ftcd", ")", "were", "significantly", "down-regulated", "in", "Gnmt-/-", "mice", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3887563", "name": "C3887563#ent", "pos": [19, 20]}}
{"token": ["The", "patient", "first", "complained", "of", "chest", "pain", "which", "was", "originally", "thought", "to", "be", "caused", "by", "a", "C0002949#ent", "<e1>", "however", ",", "nystagmus", ",", "C0392699#ent", "<e2>", ",", "spastic", "paraplesia", "and", "hyperreactivity", "to", "stimuli", "shortly", "developed", "."], "h": {"id": "C0002949", "name": "C0002949#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0392699", "name": "C0392699#ent", "pos": [22, 23]}}
{"token": ["Lemierre", "syndrome", "characterized", "by", "C0031350#ent", "<e1>", "followed", "by", "Fusobacterium", "necrobacillosis", "sepsis", "complicated", "by", "C0745497#ent", "<e2>", "infectious", "metastatic", "abscesses", "."], "h": {"id": "C0031350", "name": "C0031350#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0745497", "name": "C0745497#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "C0036572#ent", "<e1>", "were", "more", "likely", "to", "have", "an", "elevated", "CSF", "C0338271#ent", "<e2>", "(", "P", "=", "0.033", ")", "and", "to", "develop", "brainstem", "signs", "compatible", "with", "herniation", "syndromes", "P", "<", "0.0001", ")", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [12, 13]}}
{"token": ["Since", "PYR", "does", "not", "penetrate", "into", "the", "brain", ",", "it", "does", "not", "afford", "protection", "against", "C0036572#ent", "<e1>", "and", "subsequent", "neuropathology", "induced", "by", "an", "C0338271#ent", "<e2>", "agent", "such", "as", "soman", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [23, 24]}}
{"token": ["Heat-clearing", "and", "C0019120#ent", "<e1>", "effective", "in", "treating", "C0159075#ent", "<e2>", "."], "h": {"id": "C0019120", "name": "C0019120#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0159075", "name": "C0159075#ent", "pos": [7, 8]}}
{"token": ["Therefore", "cell", "lines", ",", "FM3A/TK-", "(", "deficient", "in", "thymidine", "kinase", "and", "FM3A/TS-", "(", "deficient", "in", "C1366824#ent", "<e1>", "were", "used", "to", "determine", "TK", "dependency", "and", "specificity", "for", "C1420620#ent", "<e2>", "inhibition", "."], "h": {"id": "C1366824", "name": "C1366824#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [26, 27]}}
{"token": ["C0046494#ent", "<e1>", "BCKDH", ")", ",", "a", "C0026741#ent", "<e2>", "plays", "a", "key", "role", "in", "branched-chain", "amino", "acid", "catabolism", "."], "h": {"id": "C0046494", "name": "C0046494#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [6, 7]}}
{"token": ["C0046494#ent", "<e1>", "BKD", ")", "is", "an", "C0026741#ent", "<e2>", "catalyzes", "the", "early", "stages", "branched-chain", "fatty", "acid", "BCFA", ")", "production", "."], "h": {"id": "C0046494", "name": "C0046494#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [6, 7]}}
{"token": ["However", ",", "INa", "was", "observed", "more", "frequently", "in", "human", "myocytes", "derived", "from", "C0007273#ent", "<e1>", "ischemic", "cardiopathy", "than", "in", "those", "derived", "from", "healthy", "tissues", "C0007193#ent", "<e2>", "."], "h": {"id": "C0007273", "name": "C0007273#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007193", "name": "C0007193#ent", "pos": [23, 24]}}
{"token": ["However", ",", "the", "postoperative", "abnormal", "flow", "pattern", "C1704887#ent", "<e1>", "less", "than", "C1824729#ent", "<e2>", "as", "opposed", "to", "C1704887#ent", "<e1>", "=", "C1824729#ent", "<e2>", "indicates", "the", "additional", "presence", "of", "right", "ventricular", "dysfunction"], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824729", "name": "C1824729#ent", "pos": [11, 12]}}
{"token": ["Phosphorylation", "of", "spectrin", "by", "C1334693#ent", "<e1>", "markedly", "impaired", "in", "this", "patient", ",", "whereas", "phosphorylation", "of", "C0007332#ent", "<e2>", "ws", "unimpaired", "."], "h": {"id": "C1334693", "name": "C1334693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [15, 16]}}
{"token": ["We", "studied", "40", "patients", "with", "acute", "exacerbations", "asthma", "to", "determine", "the", "efficacy", "of", "a", "3-h", "intravenous", "infusion", "of", "C0002575#ent", "<e1>", "in", "patients", "who", "were", "already", "being", "treated", "with", "inhaled", "beta-adrenergic", "agonist", "C0029193#ent", "<e2>", ")", "."], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0029193", "name": "C0029193#ent", "pos": [31, 32]}}
{"token": ["Side", "effects", "frequent", "after", "the", "administration", "of", "C0002575#ent", "<e1>", "but", "absent", "after", "aerosol", "C0029193#ent", "<e2>", "."], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029193", "name": "C0029193#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesized", "that", "Ser/Thr", "C2697656#ent", "<e1>", "may", "regulate", "protein", "kinase", "C", "C1826724#ent", "<e2>", ")", ",", "a", "critical", "signaling", "molecule", "barrier", "dysfunction", "in", "the", "promotion", "of", "barrier", "recovery", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [11, 12]}}
{"token": ["We", "determined", "the", "effects", "of", "intravesical", "instillation", "E.", "coli", "lipopolysaccharide", "C2697656#ent", "<e1>", ",", "endotoxin", ")", "on", "muscle", "contractions", "protein", "kinase", "C", "C1826724#ent", "<e2>", ")", "translocation", ",", "and", "inducible", "nitric", "oxide", "synthase", "iNOS", ")", "expression", "in", "rat", "urinary", "bladder"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [21, 22]}}
{"token": ["Activation", "of", "p53", "signaling", "pathway", "to", "activation", "of", "C0010656#ent", "<e1>", "and", "caspases", "inhibitor", "completely", "blocks", "low", "dose", "C1413892#ent", "<e2>", "induced", "apoptosis", "through", "the", "inhibition", "of", "mitochondria", "pathway"], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413892", "name": "C1413892#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "C0544482#ent", "<e1>", "detected", "a", "C1415477#ent", "<e2>", "was", "inherited", "from", "the", "father", "."], "h": {"id": "C0544482", "name": "C0544482#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415477", "name": "C1415477#ent", "pos": [7, 8]}}
{"token": ["We", "have", "cloned", "and", "characterized", "a", "human", "brain", "cDNA", "encoding", "a", "new", "C1418385#ent", "<e1>", "that", "has", "been", "called", "aminopeptidase", "O", "C1413031#ent", "<e2>", ")", "."], "h": {"id": "C1418385", "name": "C1418385#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413031", "name": "C1413031#ent", "pos": [20, 21]}}
{"token": ["These", "results", "demonstrate", "that", "continuous", "C0256103#ent", "<e1>", "differentially", "affected", "phosphorylation", "of", "PKC", "substrate", "proteins", "regulation", "of", "PKC", "C1412365#ent", "<e2>", "content", "in", "SK-N-SH", "cells", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412365", "name": "C1412365#ent", "pos": [17, 18]}}
{"token": ["Immunoblotting", "showed", "that", "whereas", "C0256103#ent", "<e1>", "caused", "a", "rapid", ",", "partial", "translocation", "of", "the", "PKC", "alpha", "C1412365#ent", "<e2>", ",", "it", "had", "no", "effect", "on", "the", "distribution", "of", "PKC", "delta"], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412365", "name": "C1412365#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "delayed", "treatment", "with", "C0078459#ent", "<e1>", ",", "a", "novel", "C0242913#ent", "<e2>", "on", "neurotransmitters", "of", "brain", "regions", "examined", "in", "rats", "with", "microsphere", "embolism-induced", "cerebral", "ischaemia", "."], "h": {"id": "C0078459", "name": "C0078459#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242913", "name": "C0242913#ent", "pos": [11, 12]}}
{"token": ["269", "patients", "with", "various", "C0009326#ent", "<e1>", "had", "been", "treated", "with", "non-steroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e2>", ")", "for", "at", "least", "three", "weeks", ",", "were", "enrolled", "in", "this", "randomised", "double-blind", "multicenter", "trial", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [13, 14]}}
{"token": ["Total", "management", "C0009326#ent", "<e1>", "children", "includes", "C0003211#ent", "<e2>", "active", "therapy", "maintenance", "of", "ADLs", ",", "and", "attention", "to", "the", "psychosocial", "development", "the", "child", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [6, 7]}}
{"token": ["The", "clinical", "and", "histologic", "features", "of", "A", "C0022568#ent", "<e1>", "are", "described", "and", "related", "to", "C1262117#ent", "<e2>", "general", "."], "h": {"id": "C0022568", "name": "C0022568#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C1262117", "name": "C1262117#ent", "pos": [14, 15]}}
{"token": ["The", "drugs", "investigated", "included", ",", "propranolol", ",", "C0026289#ent", "<e1>", ",", "oxprenolol", ",", "labetolol", ",", "timolol", ",", "C0025859#ent", "<e2>", "and", "acebutolol", "."], "h": {"id": "C0026289", "name": "C0026289#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [16, 17]}}
{"token": ["C0009014#ent", "<e1>", "has", "proved", "to", "be", "a", "clinically", "useful", "adjunct", "in", "C0002932#ent", "<e2>", "well", "as", "in", "chronic", "pain", "therapy", "it", "has", "both", "anaesthetic", "and", "analgesic-sparing", "activity", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002932", "name": "C0002932#ent", "pos": [11, 12]}}
{"token": ["The", "presence", "of", "overlapping", "features", "in", "HLH", ",", "C0019068#ent", "<e1>", "IAHS", ")", "and", "X-linked", "recessive", "lymphoproliferative", "syndrome", "C1824297#ent", "<e2>", ")", "is", "emphasized", "."], "h": {"id": "C0019068", "name": "C0019068#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1824297", "name": "C1824297#ent", "pos": [17, 18]}}
{"token": ["These", "C3541394#ent", "<e1>", "are", "distinguished", "from", "typical", "C2350322#ent", "<e2>", "by", "containing", "a", "novel", "N-terminal", "domain", "and", "exhibiting", "preferential", "substrate", "specificities", "for", "cyclomaltodextrins", "(", "CDs", ")", "over", "starch", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2350322", "name": "C2350322#ent", "pos": [7, 8]}}
{"token": ["Premedication", "with", "glucagon", "or", "C0596004#ent", "<e1>", "is", "reported", "to", "be", "effective", "in", "reducing", "C0022104#ent", "<e2>"], "h": {"id": "C0596004", "name": "C0596004#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "extent", "of", "the", "fall", "in", "C1415182#ent", "<e1>", "not", "correlate", "with", "the", "degree", "of", "activation", "of", "C1453024#ent", "<e2>"], "h": {"id": "C1415182", "name": "C1415182#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1453024", "name": "C1453024#ent", "pos": [18, 19]}}
{"token": ["From", "these", "results", ",", "we", "can", "expect", "that", "mianserin", "and", "C0050844#ent", "<e1>", "may", "have", "a", "much", "lower", "cardiac", "toxicity", "C0002600#ent", "<e2>", "."], "h": {"id": "C0050844", "name": "C0050844#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [19, 20]}}
{"token": ["C0050844#ent", "<e1>", "was", ",", "however", ",", "much", "better", "tolerated", "than", "C0002600#ent", "<e2>", ",", "and", "produced", "significantly", "fewer", "anticholinergic", "side", "effects"], "h": {"id": "C0050844", "name": "C0050844#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [10, 11]}}
{"token": ["Analogs", "with", "neutral", "and", "weakly", "basic", "capping", "groups", "the", "D-Phe", "residue", "exhibited", "excellent", "MC4R", "selectivity", "against", "C1417061#ent", "<e1>", "whereas", "those", "with", "an", "C2917660#ent", "<e2>", "moderate", "MC4R/MC1R", "selectivity", "."], "h": {"id": "C1417061", "name": "C1417061#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "most", "of", "the", "patients", "with", "the", "progressive", "C0014550#ent", "<e1>", "phenotype", "inherited", "their", "expanded", "C0002085#ent", "<e2>", "from", "their", "affected", "fathers", "."], "h": {"id": "C0014550", "name": "C0014550#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [15, 16]}}
{"token": ["Linkage", "analysis", "DNA", "markers", "to", "the", "EPM1", "gene", "progressive", "C0014550#ent", "<e1>", "Unverricht-Lundborg", "type", "showed", "that", "the", "Northern", "epilepsy", "syndrome", "not", "C0002085#ent", "<e2>", "to", "EPM1", "."], "h": {"id": "C0014550", "name": "C0014550#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [20, 21]}}
{"token": ["C1332713#ent", "<e1>", "IAP", ")", "is", "a", "widely", "expressed", "C1334693#ent", "<e2>", "multiple", "functions", "immunological", "and", "neuronal", "processes"], "h": {"id": "C1332713", "name": "C1332713#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334693", "name": "C1334693#ent", "pos": [8, 9]}}
{"token": ["Epilepsy", "with", "C0494475#ent", "<e1>", "GMA", ")", "on", "awakening", "is", "a", "benign", "C0270850#ent", "<e2>", "occurring", "around", "the", "time", "of", "puberty", "."], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0270850", "name": "C0270850#ent", "pos": [11, 12]}}
{"token": ["The", "haematological", "changes", "in", "early", "years", "neonatal", "diagnosis", "have", "been", "observed", "in", "representative", "groups", "of", "children", "with", "sickle", "cell-haemoglobin", "C", "SC", ")", "disease", ",", "sickle", "cell-beta(+", ")", "C0039730#ent", "<e1>", ",", "and", "in", "C0221019#ent", "<e2>"], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [27, 28]}, "relation": "nichd_parent_of", "t": {"id": "C0221019", "name": "C0221019#ent", "pos": [32, 33]}}
{"token": ["Eleven", "days", "postoperatively", ",", "she", "developed", "C0151594#ent", "<e1>", "fever", ",", "an", "erythematous", "macular", "rash", ",", "hepatomegaly", ",", "C0751495#ent", "<e2>", "and", "pancytopaenia", "."], "h": {"id": "C0151594", "name": "C0151594#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [17, 18]}}
{"token": ["In", "particular", ",", "macrophage", "inflammatory", "protein", "1alpha", "MIP-1alpha", ")", "is", "a", "ligand", "for", "C1332699#ent", "<e1>", "but", "not", "C1413189#ent", "<e2>", ",", "and", "eotaxin", "is", "a", "ligand", "for", "C1413189#ent", "<e2>", "but", "not", "C1332699#ent", "<e1>", "."], "h": {"id": "C1413189", "name": "C1413189#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1332699", "name": "C1332699#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "suggest", "that", "when", "anaesthesia", "is", "induced", "using", "C0039925#ent", "<e1>", ",", "a", "dose", "of", "0.20", "mg.kg-1", "of", "C1096766#ent", "<e2>", "is", "recommended", "to", "ensure", "satisfactory", "intubating", "conditions", "."], "h": {"id": "C0039925", "name": "C0039925#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1096766", "name": "C1096766#ent", "pos": [18, 19]}}
{"token": ["Inhibition", "of", "IDO", "with", "C4045546#ent", "<e1>", "prevented", "the", "development", "of", "C4015474#ent", "<e2>", ",", "which", "was", "indicated", "by", "the", "re-appearance", "of", "the", "OVA-specific", "DTH", "response", "."], "h": {"id": "C4045546", "name": "C4045546#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4015474", "name": "C4015474#ent", "pos": [10, 11]}}
{"token": ["All", "ten", "endometrioid", "prostatic", "adenocarcinomas", "prostate-specific", "antigen", "C1367456#ent", "<e1>", "immunoreactivity", ",", "in", "contrast", "to", "none", "of", "the", "control", "C0567085#ent", "<e2>", "endometrial", "carcinomas"], "h": {"id": "C1367456", "name": "C1367456#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [18, 19]}}
{"token": ["The", "identification", "of", "a", "C0057072#ent", "<e1>", "gene", "(", "XYL1", ")", "from", "the", "xylose-assimilating", "yeast", "Kluyveromyces", "lactis", "C1704887#ent", "<e2>", ")", "is", "described", "."], "h": {"id": "C0057072", "name": "C0057072#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704887", "name": "C1704887#ent", "pos": [16, 17]}}
{"token": ["Collectively", "these", "results", "suggest", "that", "C0010762#ent", "<e1>", "P-450d", "have", "been", "induced", "after", "exposure", "of", "rats", "to", "C0025942#ent", "<e2>", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025942", "name": "C0025942#ent", "pos": [16, 17]}}
{"token": ["Toll", "receptors", "C0003204#ent", "<e1>", "as", "defensin", ",", "C1418887#ent", "<e2>", "and", "granzymes", "are", "newly", "discovered", "mechanisms", "used", "by", "neutrophils", "for", "the", "first", "line", "of", "defense", "against", "invaders", "."], "h": {"id": "C0003204", "name": "C0003204#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [7, 8]}}
{"token": ["C0033218#ent", "<e1>", "(", "10", "mM", ")", ",", "Mg2+", "(5", "mM", ",", "or", "C0012789#ent", "<e2>", "(", "1", "mM", ")", "blocked", "the", "Hg2+", "contracture", "."], "h": {"id": "C0033218", "name": "C0033218#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [12, 13]}}
{"token": ["The", "function", "of", "this", "modification", "is", "not", "clear", ",", "since", "phosphorylation", "by", "C0054846#ent", "<e1>", "no", "direct", "effect", "on", "C0001022#ent", "<e2>", "activity", "."], "h": {"id": "C0054846", "name": "C0054846#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001022", "name": "C0001022#ent", "pos": [18, 19]}}
{"token": ["Senescence", "was", "characterized", "by", "a", "dramatic", "increase", "in", "C1705280#ent", "<e1>", ",", "but", "not", "C0079471#ent", "<e2>", "and", "p27", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [13, 14]}}
{"token": ["Two", "mutations", "were", "found", "in", "C1705280#ent", "<e1>", ",", "one", "in", "C0079471#ent", "<e2>", "and", "none", "in", "p21", "exon", "3"], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [10, 11]}}
{"token": ["This", "suggests", "that", "these", "metabolites", "play", "a", "role", "in", "determining", "if", "these", "C3541394#ent", "<e1>", "interact", "with", "C0006962#ent", "<e2>", "with", "C3541394#ent", "<e1>", "of", "the", "Krebs", "cycle"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006962", "name": "C0006962#ent", "pos": [16, 17]}}
{"token": ["An", "increased", "CD4:CD8", "lymphocyte", "ratio", "and", "raised", "C1333196#ent", "<e1>", "levels", "in", "bronchoalveolar", "lavage", "BAL", ")", "fluid", "are", "characteristic", "of", "C0036205#ent", "<e2>"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036205", "name": "C0036205#ent", "pos": [19, 20]}}
{"token": ["Tardive", "dystonia", "a", "C0028850#ent", "<e1>", "by", "involuntary", "muscle", "contractions", "that", "may", "be", "C3543842#ent", "<e2>", ",", "spasmodic", ",", "patterned", "or", "repetitive", ",", "associated", "with", "use", "of", "dopamine-receptor", "blocking", "agents", "."], "h": {"id": "C0028850", "name": "C0028850#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [12, 13]}}
{"token": ["It", "was", "found", "that", "this", "promoter", "can", "respond", "to", "auxins", ",", "cytokinins", ",", "methyl", "jasmonate", "MJ", ")", ",", "salicylic", "acid", "C1825840#ent", "<e1>", ")", "and", "its", "analogue", "2,6-dichloroisonicotinic", "acid", "(", "C1416431#ent", "<e2>", ")", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1416431", "name": "C1416431#ent", "pos": [29, 30]}}
{"token": ["In", "contrast", ",", "SH-L", "plants", "failed", "to", "respond", "to", "C1825840#ent", "<e1>", "but", "did", "express", "PR-1a", "following", "C1416431#ent", "<e2>", "treatment", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416431", "name": "C1416431#ent", "pos": [16, 17]}}
{"token": ["The", "main", "metabolites", "of", "C0073393#ent", "<e1>", ",", "zotepine", "and", "possibly", "C0037982#ent", "<e2>", "and", "ziprasidone", "contribute", "to", "the", "parent", "drug", "'s", "effect", "."], "h": {"id": "C0073393", "name": "C0073393#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [10, 11]}}
{"token": ["A", "study", "was", "conducted", "to", "compare", "the", "effects", "of", "experimental", "immune", "complex", "disease", "the", "development", "of", "C0017658#ent", "<e1>", "and", "aortic", "and", "C0010054#ent", "<e2>"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [21, 22]}}
{"token": ["C0016788#ent", "<e1>", "is", "a", "rare", "C0085078#ent", "<e2>", "to", "alpha-L-fucosidase", "deficiency"], "h": {"id": "C0016788", "name": "C0016788#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [5, 6]}}
{"token": ["The", "addition", "of", "C3888088#ent", "<e1>", "was", "beneficent", "as", "a", "C0423693#ent", "<e2>", "improvement", "of", "the", "structural", "status", "the", "tailings", "and", "ultimately", "through", "the", "provision", "of", "plant", "nutrients", "and", "reduction", "in", "metal", "concentrations", "."], "h": {"id": "C3888088", "name": "C3888088#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0423693", "name": "C0423693#ent", "pos": [9, 10]}}
{"token": ["She", "underwent", "C3160718#ent", "<e1>", "and", "developed", "C1709983#ent", "<e2>", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1709983", "name": "C1709983#ent", "pos": [6, 7]}}
{"token": ["The", "results", "demonstrate", "that", "C1420313#ent", "<e1>", "is", "a", "C1415740#ent", "<e2>", "binds", "lipoprotein", "lipase", ",", "when", "expressed", "on", "the", "cell", "surface", "mediates", "its", "endocytosis", "and", "degradation", "."], "h": {"id": "C1420313", "name": "C1420313#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [8, 9]}}
{"token": ["The", "differential", "diagnosis", "a", "hypermineralcorticism", "syndrome", "without", "C0020428#ent", "<e1>", "should", "include", "the", "possible", "topical", "application", "of", "C0038317#ent", "<e2>"], "h": {"id": "C0020428", "name": "C0020428#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [16, 17]}}
{"token": ["Preoperative", "studies", "of", "the", "etiology", "for", "the", "C0020428#ent", "<e1>", "using", "the", "postural", "plasma", "aldosterone", "test", "and", "adrenal", "C0038317#ent", "<e2>", "measurements", "gave", "conflicting", "results", "."], "h": {"id": "C0020428", "name": "C0020428#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [17, 18]}}
{"token": ["Ten", "patients", "with", "C0003873#ent", "<e1>", "entered", "into", "a", "24-week", "pilot", "study", "oral", "C0010592#ent", "<e2>", "A", "at", "a", "starting", "dosage", "of", "6", "mg/kg/day", ",", "followed", "by", "a", "12-week", "washout", "period", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [12, 13]}}
{"token": ["Also", ",", "C0005283#ent", "<e1>", "patients", "with", "C1415068#ent", "<e2>", "showed", "a", "significantly", "higher", "serum", "ferritin", "level", "than", "thalassaemics", "without", "C1415068#ent", "<e2>", "(", "p", "<", "0.005", ")", "."], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415068", "name": "C1415068#ent", "pos": [6, 7]}}
{"token": ["These", "pains", "included", "headache", ",", "backache", ",", "C0030193#ent", "<e1>", "the", "limbs", ",", "and", "C0008031#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0008031", "name": "C0008031#ent", "pos": [13, 14]}}
{"token": ["[", "corrected", "]", "Cysticercosis", "is", "a", "C0851341#ent", "<e1>", "different", "body", "organs", "Cysticercosis", "cellulosae", "a", "larval", "form", "of", "the", "C0162667#ent", "<e2>", ",", "Taenia", "solium", "known", "commonly", "as", "pork", "tapeworm"], "h": {"id": "C0851341", "name": "C0851341#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162667", "name": "C0162667#ent", "pos": [18, 19]}}
{"token": ["A", "definitive", "treatment", "was", "obtained", "in", "74", "%", "of", "C0237962#ent", "<e1>", "67", "%", "of", "retroperitoneal", "abscesses", "82", "%", "of", "C0000833#ent", "<e2>"], "h": {"id": "C0237962", "name": "C0237962#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [19, 20]}}
{"token": ["The", "homologous", "active", "site", "attachment", "of", "ATP", "and", "the", "structural", "distribution", "predicted", "sequence-binding", "motifs", "in", "C1418780#ent", "<e1>", "classify", "the", "enzyme", "as", "belonging", "to", "the", "C0028632#ent", "<e2>"], "h": {"id": "C1418780", "name": "C1418780#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0028632", "name": "C0028632#ent", "pos": [24, 25]}}
{"token": ["Numerous", "p53", "effectors", "upregulated", "following", "C1430988#ent", "<e1>", "deletion", ",", "including", "p21", ",", "C1335222#ent", "<e2>", ",", "PIG3", ",", "NOXA", ",", "and", "PLK2", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335222", "name": "C1335222#ent", "pos": [12, 13]}}
{"token": ["With", "increasing", "frequency", ",", "patients", "with", "impaired", "humoral", "immunity", "been", "shown", "to", "have", "a", "mycoplasmal", "infection", "results", "in", "C0032310#ent", "<e1>", ",", "sinusitis", ",", "cystitis", ",", "arthritis", ",", "C0029443#ent", "<e2>", ",", "or", "cellulitis", "."], "h": {"id": "C0032310", "name": "C0032310#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [27, 28]}}
{"token": ["These", "features", "are", "unique", "to", "C1857451#ent", "<e1>", "and", "suggest", "the", "presence", "of", "a", "distinct", "subtype", "of", "C0010481#ent", "<e2>"], "h": {"id": "C1857451", "name": "C1857451#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [16, 17]}}
{"token": ["C1857451#ent", "<e1>", "AIMAH", ")", "is", "a", "rare", "cause", "of", "endogenous", "C0010481#ent", "<e2>", "CS", ")", ",", "in", "which", "clinical", "features", "usually", "become", "apparent", "only", "after", "several", "decades", "of", "life", "."], "h": {"id": "C1857451", "name": "C1857451#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [10, 11]}}
{"token": ["C0013973#ent", "<e1>", "prescribed", "primarily", "for", "edema", ";", "gravidas", "with", "C0020538#ent", "<e2>", "excluded", "."], "h": {"id": "C0013973", "name": "C0013973#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}}
{"token": ["Four", "isolates", "were", "obtained", "from", "asymptomatic", "cases", "of", "C0392492#ent", "<e1>", "and", "the", "other", "two", "were", "associated", "with", "phoenix", "abscess", "C0031024#ent", "<e2>", "respectively", "."], "h": {"id": "C0392492", "name": "C0392492#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031024", "name": "C0031024#ent", "pos": [19, 20]}}
{"token": ["Seven", "neonatal", "patients", "with", "severe", "C0036572#ent", "<e1>", "unresponsive", "to", "conventional", "anticonvulsant", "therapy", "treated", "with", "C0024002#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [14, 15]}}
{"token": ["A", "CYP2C9", "construct", "containing", "residues", "228", "-", "340", "of", "C0960580#ent", "<e1>", "lacked", "both", "diclofenac", "and", "C0020740#ent", "<e2>", "activities", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [15, 16]}}
{"token": ["C0796327#ent", "<e1>", "inhibited", "lectin", "induced", "expression", "of", "C1420708#ent", "<e2>", "and", "CD25", "with", "IC50's", "6.48", "+", "/-", "1.31", "microM", "and", "84.1", "+", "/-", "50.0", "microM", ",", "respectively", "."], "h": {"id": "C0796327", "name": "C0796327#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [7, 8]}}
{"token": ["To", "our", "knowledge", ",", "the", "described", "case", "is", "the", "first", "case", "in", "which", "the", "three", "above-mentioned", "C0004364#ent", "<e1>", "accompanied", "by", "C0036202#ent", "<e2>"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0036202", "name": "C0036202#ent", "pos": [20, 21]}}
{"token": ["348U87", "inactivated", "C0035547#ent", "<e1>", "than", "did", "C0050283#ent", "<e2>", "."], "h": {"id": "C0035547", "name": "C0035547#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0050283", "name": "C0050283#ent", "pos": [6, 7]}}
{"token": ["Sequence", "analysis", "that", "the", "C1417679#ent", "<e1>", "encoding", "the", "amidase", "(", "C1705033#ent", "<e2>", ")", "and", "the", "NHase", "(", "anhAB", ")", "occur", "in", "a", "12.8", "kbp", "cluster", "on", "plasmid", "pRHL2", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705033", "name": "C1705033#ent", "pos": [10, 11]}}
{"token": ["The", "present", "study", "was", "conducted", "to", "examine", "the", "combined", "effects", "of", "a", "chronic", "ACEI", "ramipril", ",", "and", "a", "C1449680#ent", "<e1>", "TCV116", ",", "on", "rat", "C0018802#ent", "<e2>", "after", "myocardial", "infarction", "MI", ")", "."], "h": {"id": "C1449680", "name": "C1449680#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [24, 25]}}
{"token": ["angiotensin", "converting", "enzyme", "ACE", ")", "inhibitors", ",", "C1449680#ent", "<e1>", "beta-blockers", "and", "spironolactone", "in", "the", "management", "of", "C0018802#ent", "<e2>", "."], "h": {"id": "C1449680", "name": "C1449680#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}}
{"token": ["Prior", "to", "the", "development", "of", "C0022625#ent", "<e1>", ",", "the", "treatment", "of", "C0019655#ent", "<e2>", "blastomycosis", "was", "limited", "to", "AMB", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [11, 12]}}
{"token": ["On", "the", "other", "hand", ",", "a", "further", "C3536925#ent", "<e1>", "antiparkinson", "agent", "talipexole", ",", "which", "possesses", "C2987634#ent", "<e2>", "properties", "at", "alpha(2)-ARs", ",", "dose", "dependently", "reduced", "levels", "of", "ACh", "."], "h": {"id": "C3536925", "name": "C3536925#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [15, 16]}}
{"token": ["The", "analysis", "of", "these", "C0030956#ent", "<e1>", "in", "comparison", "to", "those", "originating", "from", "C0051464#ent", "<e2>", "corroborates", "the", "above", "sequence", "differences", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0051464", "name": "C0051464#ent", "pos": [12, 13]}}
{"token": ["C0246203#ent", "<e1>", "proved", "to", "be", "an", "effective", "and", "well-tolerated", "C0013227#ent", "<e2>", "in", "the", "treatment", "of", "hypercholesterinaemia", "in", "hypertensive", "patients", "."], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}}
{"token": ["C0246203#ent", "<e1>", "proved", "to", "be", "an", "effective", "and", "safe", "C0013227#ent", "<e2>", "for", "treating", "the", "dyslipidaemia", "of", "transplanted", "patients", "receiving", "steroid", "cyclosporin", "immunosuppression", "."], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}}
{"token": ["The", "metabolic", "requirements", "for", "the", "expression", "of", "purE", "were", "also", "monitored", "by", "measuring", "repression", "of", "the", "C0001068#ent", "<e1>", "in", "strains", "with", "various", "C1516876#ent", "<e2>", "altered", "metabolic", "backgrounds"], "h": {"id": "C0001068", "name": "C0001068#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [22, 23]}}
{"token": ["C0036442#ent", "<e1>", "also", "enabled", "C0037239#ent", "<e2>", "to", "induce", "locomotor", "stimulation", "and", "c-fos", "and", "zif/268", "messenger", "RNA", "expression", "in", "the", "normosensitive", "striatum", "of", "the", "rat", "when", "C0037239#ent", "<e2>", "alone", "caused", "no", "such", "changes", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037239", "name": "C0037239#ent", "pos": [4, 5]}}
{"token": ["The", "enhancing", "effect", "of", "CPP", "on", "THC-induced", "catalepsy", "was", "dose-dependently", "blocked", "by", "a", "muscarinic", "receptor", "antagonist", "C0036442#ent", "<e1>", ",", "and", "by", "dopamine", "D1", "D2", "receptor", "agonists", "as", "apomorphine", ",", "C0037239#ent", "<e2>", "quinpirole", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0037239", "name": "C0037239#ent", "pos": [29, 30]}}
{"token": ["We", "find", "C0080298#ent", "<e1>", "mRNA", "and", "immunoprecipitable", "c-src", "protein", "(", "C3853644#ent", "<e2>", ")", "unaltered", "by", "72", "h", "exposure", "of", "cells", "to", "1,25(OH)2D3", "(", "10(-11", ")", "to", "10(-9", ")", "M", ")", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [10, 11]}}
{"token": ["This", "study", "identified", "C0080298#ent", "<e1>", "as", "one", "such", "common", "signaling", "intermediate", "sought", "to", "determine", "whether", "C3853644#ent", "<e2>", "a", "role", "in", "cyst", "formation", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [15, 16]}}
{"token": ["These", "results", "may", "reflect", "a", "link", "between", "C1414351#ent", "<e1>", "factors", "mediating", "translational", "control", "C1413844#ent", "<e2>", "activity", ",", "which", "is", "probably", "conserved", "throughout", "the", "plant", "kingdom"], "h": {"id": "C1414351", "name": "C1414351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413844", "name": "C1413844#ent", "pos": [13, 14]}}
{"token": ["Methyl-CpG", "binding", "protein", "4", "C1417052#ent", "<e1>", ")", "is", "a", "C0766421#ent", "<e2>", "T", "and", "G", ":", "U", "DNA", "glycosylase"], "h": {"id": "C1417052", "name": "C1417052#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0766421", "name": "C0766421#ent", "pos": [9, 10]}}
{"token": ["It", "contains", "two", "DNA", "binding", "domains", "an", "C1417052#ent", "<e1>", "MBD", ")", "and", "a", "C0766421#ent", "<e2>"], "h": {"id": "C1417052", "name": "C1417052#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0766421", "name": "C0766421#ent", "pos": [13, 14]}}
{"token": ["MBOAT1", "is", "predicted", "to", "be", "a", "C0021699#ent", "<e1>", "belongs", "to", "the", "superfamily", "of", "C2742256#ent", "<e2>"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C2742256", "name": "C2742256#ent", "pos": [13, 14]}}
{"token": ["A", "dramatic", "loss", "of", "C1420120#ent", "<e1>", "been", "observed", "in", "C1862941#ent", "<e2>", "has", "been", "postulated", "to", "contribute", "to", "the", "disease", "."], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1862941", "name": "C1862941#ent", "pos": [9, 10]}}
{"token": ["C0022173#ent", "<e1>", "of", "the", "C1420188#ent", "<e2>", "enzyme", "superfamily", "control", "the", "glucuronidation", "of", "metabolites", "of", "aromatic", "hydrocarbons", "of", "N-oxidized", "aromatic", "amines", "have", "been", "identified", "in", "rats", "and", "humans", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420188", "name": "C1420188#ent", "pos": [4, 5]}}
{"token": ["The", "only", "effective", "treatment", "for", "end", "stage", "C0023895#ent", "<e1>", "to", "the", "C1412777#ent", "<e2>", "is", "OLT", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412777", "name": "C1412777#ent", "pos": [11, 12]}}
{"token": ["Diagnosis", "by", "the", "referring", "doctor", "was", "usually", "C0029408#ent", "<e1>", "of", "the", "hip", "or", "C0036396#ent", "<e2>", ",", "but", "localised", "tenderness", "and", "pain", "on", "resisted", "abduction", "were", "the", "only", "clinical", "signs"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036396", "name": "C0036396#ent", "pos": [13, 14]}}
{"token": ["C0043366#ent", "<e1>", "is", "also", "related", "pharmacologically", "to", "C0009014#ent", "<e2>", ",", "a", "relatively", "selective", "alpha", "2-agonist", "."], "h": {"id": "C0043366", "name": "C0043366#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [7, 8]}}
{"token": ["We", "present", "a", "comparative", "review", "of", "some", "toxicological", "properties", "that", "C0043366#ent", "<e1>", "shares", "with", "the", "pharmacologically", "related", "C0009014#ent", "<e2>", "and", "with", "the", "structurally", "related", "phenothiazines", "and", "the", "tricyclic", "antidepressants"], "h": {"id": "C0043366", "name": "C0043366#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [17, 18]}}
{"token": ["It", "would", "also", "allow", "the", "more", "effective", "use", "of", "a", "C0028210#ent", "<e1>", "combination", "with", "C0003392#ent", "<e2>", "more", "potent", "myelosuppressive", "properties", "."], "h": {"id": "C0028210", "name": "C0028210#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [14, 15]}}
{"token": ["C0028210#ent", "<e1>", "possess", "some", "C0003392#ent", "<e2>", "a", "single", "agent", "metastatic", "melanoma", "MM", ")", "."], "h": {"id": "C0028210", "name": "C0028210#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [4, 5]}}
{"token": ["5-Fluorouracil", ",", "Adriamycin", ",", "mitomycin", "C", "and", "C0028210#ent", "<e1>", "the", "most", "commonly", "used", "C0003392#ent", "<e2>"], "h": {"id": "C0028210", "name": "C0028210#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [13, 14]}}
{"token": ["C0063460#ent", "<e1>", "is", "a", "noncardioselective", "C1367657#ent", "<e2>", "blocking", "drug", "with", "partial", "agonist", "activity"], "h": {"id": "C0063460", "name": "C0063460#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [5, 6]}}
{"token": ["These", "findings", "indicate", "that", "the", "excessive", "tissue", "deposits", "cholesterol", "and", "C0238052#ent", "<e1>", "that", "characterize", "C0631180#ent", "<e2>", "were", "associated", "with", "hyperactive", "neutral", "sterol", "synthesis", "."], "h": {"id": "C0238052", "name": "C0238052#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0631180", "name": "C0631180#ent", "pos": [14, 15]}}
{"token": ["We", "hypothesized", "that", "C0238052#ent", "<e1>", "in", "serum", "of", "C0631180#ent", "<e2>", "patients", "might", "induce", "neuronal", "cell", "death", "the", "cerebellum", "and", "eventually", "lead", "to", "cerebellar", "ataxia"], "h": {"id": "C0238052", "name": "C0238052#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0631180", "name": "C0631180#ent", "pos": [8, 9]}}
{"token": ["Because", "adenosine", "3',5'-cyclic", "monophosphate", "cAMP", ")", "and", "C0752348#ent", "<e1>", "alter", "ion", "transporters", "I", "tested", "whether", "cholera", "and", "C0043167#ent", "<e2>", "affected", "acidification", "of", "rat", "liver", "endosomes"], "h": {"id": "C0752348", "name": "C0752348#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [17, 18]}}
{"token": ["The", "modulators", "of", "C0752348#ent", "<e1>", "forskolin", "(", "FK", ")", ",", "C0043167#ent", "<e2>", "PTX", ")", "and", "cholera", "toxin", "CTX", ")", ",", "also", "increased", "cAMP", "levels", "in", "whole", "cells", "membrane", "fragments"], "h": {"id": "C0752348", "name": "C0752348#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "not", "only", "the", "causative", "Hantaviral", "serotype", ",", "but", "also", "the", "degree", "of", "\"", "systemic", "inflammatory", "response", "syndrome", "(", "C0242966#ent", "<e1>", ")", "seems", "to", "determine", "the", "clinical", "picture", "C0035869#ent", "<e2>"], "h": {"id": "C0242966", "name": "C0242966#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0035869", "name": "C0035869#ent", "pos": [30, 31]}}
{"token": ["These", "data", "are", "supported", "by", "chromatin", "immunoprecipitation", "analysis", "which", "indicates", "that", "C1538149#ent", "<e1>", "associates", "with", "the", "promoter", "region", "C1332725#ent", "<e2>", ",", "a", "known", "E2F/Rb", "target", "gene", "."], "h": {"id": "C1538149", "name": "C1538149#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332725", "name": "C1332725#ent", "pos": [18, 19]}}
{"token": ["There", "is", "considerable", "evidence", "suggesting", "that", "genetic", "damages", "to", "human", "uridine", "diphosphate", "glucuronyltransferase", "C3541329#ent", "<e1>", ")", "gene", "located", "on", "C2931817#ent", "<e2>", "responsible", "for", "hereditary", "unconjugated", "hyperbilirubinemias", "(", "HUHB", ")", "."], "h": {"id": "C3541329", "name": "C3541329#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2931817", "name": "C2931817#ent", "pos": [19, 20]}}
{"token": ["Natural", "and", "C0017711#ent", "<e1>", "been", "used", "not", "merely", "to", "manage", "chronic", "and", "C0405580#ent", "<e2>", "replacement", "therapy", "but", "to", "manage", "a", "wide", "variety", "of", "conditions", "as", "pharmacological", "agents"], "h": {"id": "C0017711", "name": "C0017711#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [12, 13]}}
{"token": ["The", "ablation", "of", "C1706022#ent", "<e1>", "in", "gliogenic", "progenitors", "in", "vitro", "prevents", "C1414314#ent", "<e2>", "astrocyte", "differentiation", "."], "h": {"id": "C1706022", "name": "C1706022#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414314", "name": "C1414314#ent", "pos": [11, 12]}}
{"token": ["Chronic", "active", "Epstein-Barr", "virus", "C0149678#ent", "<e1>", ")", "infection", "is", "a", "severe", "C0442893#ent", "<e2>", "associated", "with", "high", "rates", "mortality", "and", "morbidity", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0442893", "name": "C0442893#ent", "pos": [11, 12]}}
{"token": ["The", "original", "Casadaban", "technique", "for", "isolating", "fused", "C0008844#ent", "<e1>", "encoding", "hybrid", "beta-galactosidase", "proteins", "a", "Mucts62", "prophage", "to", "align", "the", "C0079941#ent", "<e2>", "lacZ", "prior", "to", "selection", "."], "h": {"id": "C0008844", "name": "C0008844#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [19, 20]}}
{"token": ["This", "region", "is", "C1419895#ent", "<e1>", "with", "human", "C0795816#ent", "<e2>", "8q", "and", "9p", "."], "h": {"id": "C1419895", "name": "C1419895#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0795816", "name": "C0795816#ent", "pos": [7, 8]}}
{"token": ["The", "active", "C0014442#ent", "<e1>", "consists", "of", "two", "non-identical", "subunits", "called", "proteins", "R1", "C1705784#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705784", "name": "C1705784#ent", "pos": [12, 13]}}
{"token": ["The", "human", "C1704949#ent", "<e1>", "cDNAs", "predict", "an", "additional", "6", "C2917660#ent", "<e2>", "the", "N-terminal", "signal", "peptide", "compared", "to", "the", "rat", "C1704949#ent", "<e1>", "."], "h": {"id": "C1704949", "name": "C1704949#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [9, 10]}}
{"token": ["However", ",", "negative", "modulators", "of", "C0242898#ent", "<e1>", "transmission", "(", "Zk", "93", "426", ",", "C0145217#ent", "<e2>", ",", "RU", "33965", ")", "failed", "to", "attenuate", "the", "effects", "of", "age", "on", "behavioral", "vigilance", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0145217", "name": "C0145217#ent", "pos": [13, 14]}}
{"token": ["C0760772#ent", "<e1>", "an", "evolutionarily", "conserved", "C1413288#ent", "<e2>"], "h": {"id": "C0760772", "name": "C0760772#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413288", "name": "C1413288#ent", "pos": [5, 6]}}
{"token": ["Complications", "of", "C0011849#ent", "<e1>", "rather", "than", "the", "C0277554#ent", "<e2>", "pose", "the", "most", "challenging", "aspects", "of", "diabetic", "patient", "management"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0277554", "name": "C0277554#ent", "pos": [7, 8]}}
{"token": ["Subchronic", "exposure", "to", ",", "but", "not", "2,7-DCDD", ",", "produced", "an", "induction", "of", "several", "liver", "parameters", "including", ":", "liver", "weight", "amount", "of", "C0001214#ent", "<e1>", "amount", "of", "cytochrome", "P-450", "activity", "of", "aminopyrine-N-demethylase", "and", "activity", "of", "C0003927#ent", "<e2>"], "h": {"id": "C0001214", "name": "C0001214#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0003927", "name": "C0003927#ent", "pos": [33, 34]}}
{"token": ["Three", "of", "five", "new", "C1417679#ent", "<e1>", "share", "99", "%", "identity", "to", "the", "published", "C1425151#ent", "<e2>", "C1417679#ent", "<e1>", "from", "various", "cultivated", "potato", "accessions", ",", "while", "others", "exhibit", "96", "%", "identity", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425151", "name": "C1425151#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "vitamin", "E", "succinate", "studied", "in", "vitro", "cyclosporine", "A", "C0751039#ent", "<e1>", ")", "cytotoxicity", "in", "reference", "to", "the", "induction", "of", "heat", "shock", "protein", "70", "C1415760#ent", "<e2>", ")", "in", "rat", "hepatocytes", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [25, 26]}}
{"token": ["Upon", "incubation", "of", "crosslinked", "fibrin", "with", "C1425192#ent", "<e1>", ",", "a", "steady", "increase", "of", "D-dimer", "suggests", "that", "the", "C0014442#ent", "<e2>", "has", "a", "strong", "fibrinolytic", "activity"], "h": {"id": "C1425192", "name": "C1425192#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Here", "cyclin", "A/CDK2", "is", "shown", "to", "oppose", "C2698932#ent", "<e1>", "accumulation", ";", "conversely", ",", "C2698932#ent", "<e1>", "is", "induced", "by", "C1705523#ent", "<e1>", "and", "related", "CDK", "inhibitors", "."], "h": {"id": "C2698932", "name": "C2698932#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705523", "name": "C1705523#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "the", "variable", "number", "of", "tandem", "repeats", "the", "promoter", "region", "the", "insulin", "gene", "INS-VNTR", ",", "C0011854#ent", "<e1>", "IDDM", ")", "2", ")", "and", "cytotoxic", "T", "lymphocyte", "antigen", "4", "C1705969#ent", "<e2>", ",", "IDDM12", ")", "as", "representative", "of", "Type", "1", "diabetes", "susceptibility", "genes"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [16, 17]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [28, 29]}}
{"token": ["Genetic", "predisposition", "C0011854#ent", "<e1>", "is", "connected", "with", "HLA", ",", "C1705969#ent", "<e2>", "and", "insulin", "gene", "region"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [2, 3]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [9, 10]}}
{"token": ["Two", "C1258847#ent", "<e1>", "been", "identified", ";", "ACAT1", "is", "expressed", "ubiquitously", "while", "C1420305#ent", "<e2>", "is", "primarily", "expressed", "in", "intestine", "and", "liver", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420305", "name": "C1420305#ent", "pos": [11, 12]}}
{"token": ["On", "the", "other", "hand", ",", "in", "arabinose-utilizing", "merodiploids", ",", "missense", "mutations", "longer", "exhibited", "hyperinducibility", "but", "displayed", "a", "C2987364#ent", "<e1>", "level", "of", "C0029073#ent", "<e2>", "expression", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [21, 22]}}
{"token": ["In", "C2987364#ent", "<e1>", "Escherichia", "coli", "expression", "of", "the", "C0029073#ent", "<e2>", "negatively", "regulated", "by", "the", "Gal", "repressor", "is", "induced", "10-", "to", "15-fold", "when", "the", "repressor", "is", "inactivated", "by", "an", "inducer", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [8, 9]}}
{"token": ["These", "results", "indicate", "that", "the", "Lys173", "and", "the", "IC-conversion", "allele", "of", "the", "C1413857#ent", "<e1>", "an", "increased", "risk", "for", "C0020538#ent", "<e2>", "northern", "Han", "Chinese", "women", "."], "h": {"id": "C1413857", "name": "C1413857#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["1H", ",", "13C", "NMR", "of", "each", "C0036023#ent", "<e1>", "were", "assigned", "using", "2D-NMR", "techniques", ",", "including", "COSY", ",", "C0245636#ent", "<e2>", ",", "HSQC-TOCSY", ",", "HMBC", ",", "CH(2)-selected", "E-HSQC", ",", "and", "CH(2)-selected", "E-HSQC-TOCSY", "."], "h": {"id": "C0036023", "name": "C0036023#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0245636", "name": "C0245636#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "VEGF", "appears", "to", "mediate", "its", "mitogenic", "effects", "through", "the", "activation", "of", "the", "C0250414#ent", "<e1>", "and", "PKC", "pathway", ",", "involving", "predominately", "C1706144#ent", "<e2>", "isoform", "activation", "in", "endothelial", "cells"], "h": {"id": "C0250414", "name": "C0250414#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706144", "name": "C1706144#ent", "pos": [22, 23]}}
{"token": ["Faecal", "chymotrypsin", "found", "to", "be", "useful", "in", "evaluating", "the", "degree", "of", "C0267963#ent", "<e1>", "subjects", "with", "C0029896#ent", "<e2>", "of", "the", "pancreas", "that", "had", "already", "been", "clinically", "ascertained", "."], "h": {"id": "C0267963", "name": "C0267963#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [15, 16]}}
{"token": ["Our", "laboratory", "has", "shown", "that", "troglitazone", ",", "a", "thiazolidinedione", "and", "peroxisomal", "proliferator", "activated", "receptor", "gamma", "C1418779#ent", "<e1>", ")", "agonist", ",", "prevents", "mesangial", "expansion", "and", "C1417247#ent", "<e2>", "in", "diabetic", "rats", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417247", "name": "C1417247#ent", "pos": [24, 25]}}
{"token": ["Platelets", "adherent", "to", "C0009325#ent", "<e1>", "produced", "significant", "levels", "of", "C0914069#ent", "<e2>", "PAF", ")", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0914069", "name": "C0914069#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "platelet", "response", "other", "agonists", "(", "ADP", ",", "epinephrine", ",", "C0009325#ent", "<e1>", ",", "thrombin", ",", "and", "C0914069#ent", "<e2>", "was", "essentially", "unaffected", "by", "butyrate", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0914069", "name": "C0914069#ent", "pos": [18, 19]}}
{"token": ["The", "chronic", "syndrome", "were", "hyperreactive", "malaria", "syndrome", "(", "Tropical", "splenomegaly", "3", ",", "repeated", "haemolysis", "2", "chronic", "simple", "malaria", "with", "positive", "C0242723#ent", "<e1>", "and", "normal", "Igm", "levels", ",", "and", "cerebellar", "ataxia", "C0040822#ent", "<e2>"], "h": {"id": "C0242723", "name": "C0242723#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0040822", "name": "C0040822#ent", "pos": [30, 31]}}
{"token": ["This", "randomised", ",", "double-blind", "study", "the", "C0728960#ent", "<e1>", "intra-articular", "injection", "morphine", "and", "C0006400#ent", "<e2>", "during", "therapeutic", "arthroscopic", "knee", "surgery"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006400", "name": "C0006400#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", "to", "the", "reversible", "C2987634#ent", "<e1>", "binding", "that", "regulates", "signaling", "by", "most", "G", "protein-coupled", "receptors", "C1367690#ent", "<e2>", ")", ",", "PAR1", "is", "activated", "by", "an", "irreversible", "proteolytic", "mechanism", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367690", "name": "C1367690#ent", "pos": [16, 17]}}
{"token": ["Although", "functioning", "of", "antagonists", "as", "C2987634#ent", "<e1>", "has", "been", "shown", "to", "be", "species-dependent", "for", "several", "C1367690#ent", "<e2>", ",", "the", "dependence", "of", "this", "on", "an", "extracellular", "domain", "not", "been", "described", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367690", "name": "C1367690#ent", "pos": [15, 16]}}
{"token": ["The", "transfection", "of", "C1415014#ent", "<e1>", "promoter", "constructs", "together", "with", "expression", "vectors", "C2987236#ent", "<e2>", "or", "constitutively", "active", "PKB", "revealed", "that", "the", "C1415014#ent", "<e1>", "promoter", "region", "mediates", "the", "response", "to", "PI3K/PKB", "."], "h": {"id": "C1415014", "name": "C1415014#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987236", "name": "C2987236#ent", "pos": [11, 12]}}
{"token": ["The", "C0017356#ent", "<e1>", "encoded", "by", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "and", "simian", "immunodeficiency", "virus", "type", "1", "C4084736#ent", "<e2>", ")", "increase", "viral", "loads", "infected", "hosts", "and", "accelerate", "clinical", "progression", "AIDS", "."], "h": {"id": "C0017356", "name": "C0017356#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4084736", "name": "C4084736#ent", "pos": [18, 19]}}
{"token": ["The", "possibility", "that", "C1852403#ent", "<e1>", "represses", "the", "activity", "of", "the", "C0003805#ent", "<e2>", "ovarian", "promoter", ",", "thus", "being", "part", "of", "the", "mechanism", "underlying", "the", "effects", "of", "LH", "was", "investigated", "."], "h": {"id": "C1852403", "name": "C1852403#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "possible", "structural", "and", "functional", "relationships", "of", "C3541324#ent", "<e1>", "and", "other", "C1420613#ent", "<e2>", "containing", "genes", ",", "we", "analyzed", "genomic", "organization", "the", "murine", "C3541324#ent", "<e1>", "gene", "."], "h": {"id": "C3541324", "name": "C3541324#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420613", "name": "C1420613#ent", "pos": [12, 13]}}
{"token": ["We", "studied", "the", "expression", "by", "E.", "coli", "the", "C3540820#ent", "<e1>", "of", "human", "papillomavirus", "type", "16", "HPV16", ")", "using", "the", "C0079429#ent", "<e2>", "derived", "from", "the", "'", "prototype", "'", "HPV16", "genome", "."], "h": {"id": "C3540820", "name": "C3540820#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}}
{"token": ["The", "nucleotide", "sequence", "the", "C3540820#ent", "<e1>", "64.4", "%", "similar", "to", "that", "of", "C0079429#ent", "<e2>", "23", "of", "coliphage", "T4"], "h": {"id": "C3540820", "name": "C3540820#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "we", "sought", "to", "detect", "the", "expression", "of", "the", "presumed", "downstream", "targets", "of", "C1430988#ent", "<e1>", ",", "such", "as", "P-Akt", ",", "C1420433#ent", "<e2>", ",", "and", "cyclin", "D1", "immunohistochemistry", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420433", "name": "C1420433#ent", "pos": [21, 22]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "compare", "nifedipine", "and", "C1815010#ent", "<e1>", "in", "the", "treatment", "of", "de", "novo", "C0020538#ent", "<e2>", "orthotopic", "liver", "transplantation", "OLT", ")", "."], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["C1815010#ent", "<e1>", "has", "been", "shown", "to", "be", "effective", "in", "C0020538#ent", "<e2>", "coronary", "artery", "disease", "patients", "with", "end-stage", "renal", "disease", "on", "maintenance", "hemodialysis", "."], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}}
{"token": ["The", "NTera2/D1", "teratocarcinoma", "cell-line", "(", "or", "NT2-N", "cells", ")", "gives", "rise", "to", "neuron-like", "cells", "called", "C1419758#ent", "<e1>", "neurons", "after", "exposure", "to", "C0022265#ent", "<e2>"], "h": {"id": "C1419758", "name": "C1419758#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [21, 22]}}
{"token": ["In", "primary", "cultured", "C0669372#ent", "<e1>", ",", "tungstate", "showed", "C1416454#ent", "<e2>", "which", "led", "to", "an", "increase", "in", "glycogen", "synthesis", "accumulation", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416454", "name": "C1416454#ent", "pos": [8, 9]}}
{"token": ["In", "summary", ",", "this", "bioassay", "demonstrates", "the", "action", "of", "insulin", "on", "glycogen", "formation", "C0669372#ent", "<e1>", "and", "provides", "a", "rapid", "and", "sensitive", "measurement", "of", "C1416454#ent", "<e2>", "could", "facilitate", "screening", "studies"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416454", "name": "C1416454#ent", "pos": [23, 24]}}
{"token": ["A", "54-year-old", "man", "with", "C0221056#ent", "<e1>", "initially", "responsive", "to", "corticosteroids", "and", "C0025677#ent", "<e2>", "developed", "severe", "myalgias", ",", "increasing", "weakness", ",", "and", "fevers", "."], "h": {"id": "C0221056", "name": "C0221056#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [11, 12]}}
{"token": ["We", "also", "review", "the", "pharmacokinetics", "of", "C0086303#ent", "<e1>", "in", "patients", "with", "C2316401#ent", "<e2>"], "h": {"id": "C0086303", "name": "C0086303#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2316401", "name": "C2316401#ent", "pos": [11, 12]}}
{"token": ["Phenethylamines", "were", "extracted", "from", "brain", "and", "liver", "of", "rats", "with", "phenylketonuria-like", "characteristics", "produced", "in", "vivo", "inhibition", "of", "C1418251#ent", "<e1>", "EC", "1.14.3.1", ")", "with", "C0030135#ent", "<e2>", ",", "with", "or", "without", "phenylalanine", "administration", "."], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [23, 24]}}
{"token": ["Neither", "the", "rate", "of", "synthesis", "nor", "the", "rate", "of", "degradation", "of", "C1418251#ent", "<e1>", "changed", "by", "C0030135#ent", "<e2>", "(", "pClPhe", ")", "treatment", "."], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [15, 16]}}
{"token": ["We", "examined", "the", "safety", "of", "zidovudine", "and", "the", "tolerance", "of", "and", "therapeutic", "response", "the", "C0013227#ent", "<e1>", "in", "88", "children", "with", "advanced", "C0343755#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0343755", "name": "C0343755#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "apoptosis", "in", "MCF-7", "cell", "induced", "by", "upregulation", "of", "C3272392#ent", "<e1>", "activation", "of", "Caspase-3", "activated", "C0011522#ent", "<e2>", "."], "h": {"id": "C3272392", "name": "C3272392#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [16, 17]}}
{"token": ["The", "correction", "of", "the", "total", "hypermetropic", "C0034951#ent", "<e1>", "the", "management", "of", "C0014877#ent", "<e2>", "is", "well", "accepted", "."], "h": {"id": "C0034951", "name": "C0034951#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014877", "name": "C0014877#ent", "pos": [11, 12]}}
{"token": ["This", "effect", "of", "C0025853#ent", "<e1>", "was", "limited", "to", "the", "adrenal", "response", "C2698414#ent", "<e2>", ":", "on", "a", "given", "Na", "intake", ",", "the", "mean", "blood", "pressure", "response", "C2698414#ent", "<e2>", "was", "similar", "both", "with", "and", "without", "concomitant", "C0025853#ent", "<e1>", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [3, 4]}}
{"token": ["Alternatively", ",", "it", "is", "possible", "that", "the", "stimulation", "of", "C2698414#ent", "<e1>", "release", "induced", "by", "C0025853#ent", "<e2>", "does", "not", "occur", "through", "inhibition", "of", "dopamine", "receptors", "rather", "through", "interaction", "with", "other", "neuroendocrine", "pathways"], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [14, 15]}}
{"token": ["We", "also", "found", "that", "in", "the", "presence", "of", "CL", "and", "C0010583#ent", "<e1>", "free", "LA", "oxidized", "and", "C1420423#ent", "<e2>", "monoepoxides", "were", "produced", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [16, 17]}}
{"token": ["This", "in", "vitro", "deoxyribonuclease", "activity", "completely", "inhibited", "by", "purified", "inhibitor", "of", "caspase-activated", "deoxyribonuclease", "protein", "the", "specific", "endogenous", "inhibitor", "of", "C1504769#ent", "<e1>", "or", "by", "C1413983#ent", "<e2>"], "h": {"id": "C1504769", "name": "C1504769#ent", "pos": [19, 20]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413983", "name": "C1413983#ent", "pos": [23, 24]}}
{"token": ["This", "in", "vitro", "deoxyribonuclease", "activity", "completely", "inhibited", "by", "purified", "inhibitor", "of", "C1504769#ent", "<e1>", "the", "specific", "endogenous", "inhibitor", "of", "caspase-activated", "deoxyribonuclease", "or", "by", "C1413983#ent", "<e2>"], "h": {"id": "C1504769", "name": "C1504769#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413983", "name": "C1413983#ent", "pos": [22, 23]}}
{"token": ["These", "results", "indicate", "that", "HDB", "allows", "C1504769#ent", "<e1>", "enter", "the", "nucleus", "and", "degrade", "chromosomal", "DNA", "induces", "C1413983#ent", "<e2>", "degradation", "."], "h": {"id": "C1504769", "name": "C1504769#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413983", "name": "C1413983#ent", "pos": [16, 17]}}
{"token": ["Leupeptin", ",", "antipain", ",", "an", "epoxysuccinate", "derivative", "(", "C0058882#ent", "<e1>", ")", ",", "and", "alkylating", "agents", "potent", "inhibitors", "of", "the", "purified", "C0014442#ent", "<e2>", "."], "h": {"id": "C0058882", "name": "C0058882#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}}
{"token": ["L-trans-epoxysuccinylleucylamido", "(", "4-guanidino", ")", "butane", "(", "C0058882#ent", "<e1>", ")", "and", "iodoacetic", "acid", "strongly", "suggesting", "that", "the", "purified", "C0014442#ent", "<e2>", "belongs", "to", "the", "cysteine", "family", "proteases", "."], "h": {"id": "C0058882", "name": "C0058882#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["The", "purified", "C0014442#ent", "<e1>", "was", "activated", "by", "dithiothreitol", "and", "cysteine", "while", "it", "was", "substantially", "inhibited", "by", "C0058882#ent", "<e2>", ",", "suggesting", "the", "purified", "C0014442#ent", "<e1>", "belongs", "to", "the", "cysteine", "proteinase", "family"], "h": {"id": "C0058882", "name": "C0058882#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}}
{"token": ["The", "CT", "findings", "were", "as", "follows", ":", "C0520575#ent", "<e1>", "6", ")", ",", "lobar", "nephronia", "(", "6", ")", ",", "C0034186#ent", "<e2>", "2", ")", "."], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [18, 19]}}
{"token": ["These", "results", "suggest", "that", "this", "rat", "model", "shows", "the", "characteristic", "feature", "of", "C0520575#ent", "<e1>", "to", "C.", "albicans", "that", "the", "severity", "of", "C0034186#ent", "<e2>", "be", "estimated", "from", "Candida", "counts", "bladder", "urine"], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [21, 22]}}
{"token": ["C0520575#ent", "<e1>", "a", "renal", "inflammatory", "disease", "has", "similarities", "to", "both", "C0034186#ent", "<e2>", "and", "renal", "abscess"], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [10, 11]}}
{"token": ["C0035179#ent", "<e1>", "induced", "hypothermia", ",", "which", "was", "reversed", "by", "C0085208#ent", "<e2>", "administration", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085208", "name": "C0085208#ent", "pos": [9, 10]}}
{"token": ["C0017868#ent", "<e1>", "glycerolphosphate", "acyltransferase", "phosphatidate", "phosphohydrolase", "CTP", ":", "phosphatidate", "cytidylyltransferase", "and", "C1413284#ent", "<e2>", "unchanged", "in", "the", "intact", "cell", "as", "well", "as", "during", "incubation", "with", "protein", "kinases", "in", "vitro"], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413284", "name": "C1413284#ent", "pos": [11, 12]}}
{"token": ["We", "identified", "66", "C1539696#ent", "<e1>", ",", "when", "depleted", ",", "specifically", "inhibit", "C3252090#ent", "<e2>", "growth", ",", "but", "not", "a", "non-IRES-containing", "RNA", "virus"], "h": {"id": "C1539696", "name": "C1539696#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3252090", "name": "C3252090#ent", "pos": [11, 12]}}
{"token": ["Several", "stress", "echocardiography", "C1414863#ent", "<e1>", ")", "modalities", "have", "been", "introduced", "for", "diagnosing", "C0010054#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [12, 13]}}
{"token": ["Therefore", ",", "we", "conclude", "that", "C1414863#ent", "<e1>", "provides", "incremental", "prognostic", "information", "in", "patients", "with", "chest", "pain", "critical", "C0010054#ent", "<e2>"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "all", "members", "of", "the", "TREK", "familyare", "activated", "by", "C0242912#ent", "<e1>", "such", "as", "C0073379#ent", "<e2>", ",", "polyunsaturated", "fatty", "acids", "lysophospholipids", ",", "suggesting", "that", "these", "channels", "play", "an", "important", "role", "in", "neuroprotection", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0073379", "name": "C0073379#ent", "pos": [15, 16]}}
{"token": ["Altogether", ",", "these", "results", "suggest", "a", "C0242912#ent", "<e1>", "MPEP", "as", "well", "as", "C0073379#ent", "<e2>", "at", "both", "behavioral", "and", "cellular", "levels", "excitatory", "amino", "acid-induced", "toxicity", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0073379", "name": "C0073379#ent", "pos": [12, 13]}}
{"token": ["A", "C0242912#ent", "<e1>", "such", "as", "C0073379#ent", "<e2>", ",", "is", "more", "effective", "at", "an", "early", "stage", "disease", ",", "when", "more", "undamaged", "neurons", "remain", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0073379", "name": "C0073379#ent", "pos": [5, 6]}}
{"token": ["High", "dose", "C0936073#ent", "<e1>", "failed", "to", "control", "severe", "C0151740#ent", "<e2>", "29", "patients", "(", "44", "%", ")", "who", "had", "a", "fulminant", ",", "malignant", "course"], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [8, 9]}}
{"token": ["We", "report", "two", "cases", "of", "children", ",", "7", "and", "14", "yr", "old", ",", "in", "whom", "prolonged", "infusion", "of", "C0936073#ent", "<e1>", "TS", ")", "was", "used", "to", "C0151740#ent", "<e2>", "unresponsive", "to", "conventional", "therapy"], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [25, 26]}}
{"token": ["C0936073#ent", "<e1>", "is", "frequently", "used", "for", "the", "treatment", "of", "C0151740#ent", "<e2>", "severe", "head", "injury", "is", "associated", "with", "immunosuppressive", "effects"], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [9, 10]}}
{"token": ["We", "have", "characterized", "the", "role", "of", "tyrosine", "phosphorylation", "C0033713#ent", "<e1>", "by", "insulin-like", "growth", "factors", "I", "II", "(", "IGF-I", "and", "C1708416#ent", "<e2>", ")", "in", "the", "Madin-Darby", "canine", "kidney", "MDCK", ")", "cell", "line"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1708416", "name": "C1708416#ent", "pos": [19, 20]}}
{"token": ["The", "C0003209#ent", "<e1>", "two", "novel", "C0006683#ent", "<e2>", "AGN", "190742", "and", "AGN", "190744", ",", "were", "evaluated", "in", "murine", "models", "of", "cutaneous", "inflammation"], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006683", "name": "C0006683#ent", "pos": [5, 6]}}
{"token": ["The", "smallest", "truncated", "C1413001#ent", "<e1>", "variant", "still", "active", "in", "regulating", "fluid", "phase", "C4b", "comprised", "C1424854#ent", "<e2>", "-", "3", "."], "h": {"id": "C1413001", "name": "C1413001#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1424854", "name": "C1424854#ent", "pos": [14, 15]}}
{"token": ["From", "this", "cluster", ",", "pure", "C0007761#ent", "<e1>", "with", "the", "SCA4", ",", "C1854369#ent", "<e2>", ",", "and", "SCA16", "locus", "been", "isolated", "."], "h": {"id": "C0007761", "name": "C0007761#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1854369", "name": "C1854369#ent", "pos": [11, 12]}}
{"token": ["Studies", "conducted", "on", "the", "prevention", "of", "ischemic", "heart", "disease", "C0151744#ent", "<e1>", ")", "with", "3-hydroxy-3-methylglutaryl", "coenzyme", "A", "reductase", "inhibitors", "statins", ")", ",", "using", "C0085542#ent", "<e2>", "and", "simvastatin", ",", "unequivocally", "show", "reductions", "in", "overall", "mortality", "cardiovascular", "mortality", "acute", "myocardial", "infarction", "other", "coronary", "events"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085542", "name": "C0085542#ent", "pos": [22, 23]}}
{"token": ["Analysis", "of", "mutations", "in", "C1528376#ent", "<e1>", "has", "previously", "led", "to", "the", "conclusion", "that", "severity", "of", "disease", "in", "C1412841#ent", "<e2>", "can", "not", "be", "predicted", "from", "the", "specific", "mutation", "of", "C1528376#ent", "<e1>", "."], "h": {"id": "C1412841", "name": "C1412841#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1528376", "name": "C1528376#ent", "pos": [4, 5]}}
{"token": ["C0035920#ent", "<e1>", "is", "a", "C0042769#ent", "<e2>", "minor", "morbidity", "and", "few", "complication", "unless", "it", "is", "contracted", "by", "a", "pregnant", "woman", "."], "h": {"id": "C0035920", "name": "C0035920#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [4, 5]}}
{"token": ["It", "is", "now", "hypothesized", "that", "C1522428#ent", "<e1>", "and", "endothelin-treated", "mesangial", "cells", "form", "distinct", "molecular", "species", "C0012262#ent", "<e2>", "which", "may", "serve", "different", "roles", "as", "intracellular", "signaling", "molecules"], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012262", "name": "C0012262#ent", "pos": [15, 16]}}
{"token": ["It", "appears", "that", "C0060135#ent", "<e1>", ",", "like", "phenobarbital", "and", "valproic", "acid", "decreases", "the", "frequency", "of", "C0036572#ent", "<e2>", "by", "decreasing", "seizure", "spread", "and", "increasing", "seizure", "threshold", "."], "h": {"id": "C0060135", "name": "C0060135#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [15, 16]}}
{"token": ["Significantly", ",", "the", "induction", "of", "apoptosis", "by", "hyaluronidases", "was", "independent", "of", "catalytic", "activity", "because", "enzymatically", "inactive", "C1577331#ent", "<e1>", "D157A/E159A", ")", "was", "as", "efficient", "as", "the", "wild-type", "C0027203#ent", "<e2>", "in", "apoptosis", "induction", "."], "h": {"id": "C1577331", "name": "C1577331#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [26, 27]}}
{"token": ["C0268436#ent", "<e1>", "PHA-1", ")", "is", "a", "rare", "C0006625#ent", "<e2>", "soon", "after", "birth", ",", "characterized", "by", "apathy", "and", "severe", "dehydration", "accompanied", "by", "hyponatremia", ",", "hyperkalemia", ",", "and", "metabolic", "acidosis", "high", "plasma", "aldosterone", "concentrations", "."], "h": {"id": "C0268436", "name": "C0268436#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006625", "name": "C0006625#ent", "pos": [7, 8]}}
{"token": ["To", "observe", "the", "effect", "of", "theo-polyphenols", "(", "C1416805#ent", "<e1>", ")", "on", "oxygen", "free", "radicals", "hemorrheology", "in", "patients", "with", "C0085580#ent", "<e2>"], "h": {"id": "C1416805", "name": "C1416805#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [18, 19]}}
{"token": ["Both", "species", "have", "strong", "exophilic", "and/or", "exophagic", "habits", "such", "that", "they", "might", "elude", "vector", "control", "against", "C1420025#ent", "<e1>", "and", "endophagic", "C0024530#ent", "<e2>", "vectors", "."], "h": {"id": "C1420025", "name": "C1420025#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [20, 21]}}
{"token": ["The", "vector", "is", "Anopheles", "farauti", "C1420025#ent", "<e1>", "mosquito", ",", "which", "transmits", "also", "C0024530#ent", "<e2>", "."], "h": {"id": "C1420025", "name": "C1420025#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [12, 13]}}
{"token": ["The", "hydrophobic", "anchor", "C1419892#ent", "<e1>", "in", "the", "Golgi", "and", "plasma", "membranes", "insensitive", "to", "treatment", "with", "C0089795#ent", "<e2>", "conditions", "in", "which", "alkaline", "phosphatase", "sensitive", ";", "this", "suggests", "that", "the", "hydrophobic", "anchor", "C1419892#ent", "<e1>", "is", "the", "core", "protein", "."], "h": {"id": "C1419892", "name": "C1419892#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0089795", "name": "C0089795#ent", "pos": [15, 16]}}
{"token": ["Spinal", "cords", "15", "species", "representing", "six", "classes", "of", "vertebrates", "and", "the", "protochordate", "amphioxus", "examined", "with", "histochemical", "methods", "for", "C1257646#ent", "<e1>", ",", "ATPase", ",", "LDH", ",", "PAS", ",", "and", "C0917783#ent", "<e2>", "."], "h": {"id": "C1257646", "name": "C1257646#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0917783", "name": "C0917783#ent", "pos": [28, 29]}}
{"token": ["Pretreatment", "with", "the", "serotonin-depleting", "agent", ",", "C0000544#ent", "<e1>", "(", "5,7-DHT", ")", ",", "did", "not", "inhibit", "the", "C0009952#ent", "<e2>", "response", "to", "IL-1", "."], "h": {"id": "C0000544", "name": "C0000544#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [16, 17]}}
{"token": ["The", "secretion", "of", "dimeric", "inhibin-A", "and", "C1334130#ent", "<e1>", "from", "antral", "but", "not", "mural", "cells", "responsive", "to", "C0016424#ent", "<e2>", "."], "h": {"id": "C1334130", "name": "C1334130#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [16, 17]}}
{"token": ["Activating", "mutations", "in", "the", "C0079429#ent", "<e1>", "that", "encodes", "the", "alpha", "subunit", "C1366550#ent", "<e2>", "G(S)alpha", ")", "has", "been", "described", "in", "monostotic", "and", "polyostotic", "fibrous", "dysplasia", "in", "the", "McCune-Albright", "syndrome"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366550", "name": "C1366550#ent", "pos": [11, 12]}}
{"token": ["Recently", ",", "a", "C0079429#ent", "<e1>", "encoding", "a", "C1366550#ent", "<e2>", "gpa3", ",", "was", "isolated", "and", "has", "subsequently", "been", "implicated", "in", "pheromone", "signal", "transduction"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366550", "name": "C1366550#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "the", "calcium", "signal", "by", "C1705340#ent", "<e1>", "is", "selectively", "modulated", "by", "activation", "of", "the", "C3811132#ent", "<e2>", "receptor.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3811132", "name": "C3811132#ent", "pos": [15, 16]}}
{"token": ["The", "C1366515#ent", "<e1>", "and", "electronic", "spectra", "the", "melt", "of", "Fe(PPIXDME)Cl", "in", "C3540045#ent", "<e2>", "been", "also", "measured", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540045", "name": "C3540045#ent", "pos": [11, 12]}}
{"token": ["Reflex", "sympathetic", "dystrophy", "C1527353#ent", "<e1>", "is", "a", "poorly", "defined", "C0039082#ent", "<e2>", "in", "which", "the", "patient", "develops", "pain", "disproportionate", "the", "cause", "."], "h": {"id": "C1527353", "name": "C1527353#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [9, 10]}}
{"token": ["In", "particular", ",", "it", "has", "been", "shown", "that", "strains", "carrying", "the", "C0000999#ent", "<e1>", "ALS", ")", "gene", "not", "only", "produce", "less", "C0000979#ent", "<e2>", "but", "also", "have", "a", "higher", "ATP", "yield", "."], "h": {"id": "C0000999", "name": "C0000999#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [20, 21]}}
{"token": ["The", "genes", "for", "two", "copper-transporting", "ATPases", "ATP7A", "and", "ATP7B", ",", "are", "defective", "in", "the", "C0019247#ent", "<e1>", "copper", "imbalance", ",", "Menkes", "disease", "(", "C0022716#ent", "<e2>", ")", "and", "Wilson", "disease", "WND", ")", ",", "respectively", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0022716", "name": "C0022716#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "the", "effects", "of", "hexamethylene", "bisacetamide", "HMBA", ")", "on", "related", "C0017337#ent", "<e1>", "expression", "of", "apoptosis", "and", "cell", "proliferating", "human", "mucoepidermoid", "carcinoma", "cell", "line", "C2986709#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2986709", "name": "C2986709#ent", "pos": [24, 25]}}
{"token": ["ACh-induced", "CD", "increases", "resistant", "to", "L-NAME", "and", "indomethacin", "were", "reduced", "after", "the", "administration", "of", "intracoronary", "quinacrine", ",", "an", "inhibitor", "of", "C0031667#ent", "<e1>", "or", "proadifen", ",", "an", "inhibitor", "of", "C0010762#ent", "<e2>"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [28, 29]}}
{"token": ["C0031667#ent", "<e1>", ",", "lipoxygenase", ",", "or", "C0010762#ent", "<e2>", "inhibition", "had", "no", "effect", "the", "afferent", "arteriolar", "vasoconstriction", "norepinephrine", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [6, 7]}}
{"token": ["In", "addition", "to", "IFN-gamma", ",", "the", "endotoxin", "lipopolysaccharide", "C2697656#ent", "<e1>", ")", "up-regulated", "FH-specific", "mRNA", "nearly", "10-fold", "in", "C1705593#ent", "<e2>", "after", "stimulation", "at", "concentrations", "of", "10", "or", "1", "ng/ml", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705593", "name": "C1705593#ent", "pos": [17, 18]}}
{"token": ["In", "ART", ",", "ME-A", ",", "P", "must", "be", "converted", "by", "a", "C0006938#ent", "<e1>", "sensitive", "enzyme", "to", "exert", "C0027410#ent", "<e2>", "action", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027410", "name": "C0027410#ent", "pos": [17, 18]}}
{"token": ["One", "mutant", "(", "C3553942#ent", "<e1>", ")", "was", "rapidly", "outcompeted", "by", "the", "C1883559#ent", "<e2>"], "h": {"id": "C3553942", "name": "C3553942#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [11, 12]}}
{"token": ["2-mercaptobenzothiazole", "(", "C1335267#ent", "<e1>", ")", ",", "N-isopropyl-N'-phenyl-p-phenylenediamine", "(", "IPPD", ")", "and", "C0043486#ent", "<e2>", "ZDEC", ")", ",", "were", "evaluated", "using", "the", "murine", "local", "lymph", "node", "assay"], "h": {"id": "C1335267", "name": "C1335267#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0043486", "name": "C0043486#ent", "pos": [11, 12]}}
{"token": ["trh", "expression", "in", "the", "salivary", "duct", "controlled", "by", "the", "C1335843#ent", "<e1>", "Sex", "combs", "reduced", "(", "Scr", ")", ",", "and", "by", "another", "C0036091#ent", "<e2>", "fork", "head", "fkh", ")", "."], "h": {"id": "C1335843", "name": "C1335843#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [21, 22]}}
{"token": ["Equivalent", "mutations", ",", "introduced", "to", "the", "human", "C1456380#ent", "<e1>", ",", "rendered", "the", "C0027203#ent", "<e2>", "active", "even", "when", "produced", "in", "Escherichia", "coli", "showing", "that", "the", "mutations", "increased", "the", "intrinsic", "catalytic", "activity", "p38", "."], "h": {"id": "C1456380", "name": "C1456380#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["C0268487#ent", "<e1>", "in", "implementation", "of", "secondary", "prevention", "C0010068#ent", "<e2>", "CHD", ")", "have", "been", "identified", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [7, 8]}}
{"token": ["The", "peptides", "in", "this", "study", "were", "also", "assayed", "with", "C0108554#ent", "<e1>", "the", "casein", "kinase", "the", "mammary", "gland", "that", "the", "specificities", "of", "these", "C0010536#ent", "<e2>", "could", "be", "compared", "to", "that", "of", "casein", "kinase", "II"], "h": {"id": "C0108554", "name": "C0108554#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [22, 23]}}
{"token": ["Mutations", "in", "the", "inositol", "5-phosphatase", "OCRL", "are", "responsible", "for", "C0028860#ent", "<e1>", "an", "X-linked", "disorder", "by", "bilateral", "cataracts", "mental", "retardation", "neonatal", "hypotonia", "and", "C0341703#ent", "<e2>", "and", "for", "Dent", "disease", "another", "X-linked", "condition", "characterized", "by", "kidney", "reabsorption", "defects", "."], "h": {"id": "C0028860", "name": "C0028860#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0341703", "name": "C0341703#ent", "pos": [22, 23]}}
{"token": ["Mutations", "in", "the", "inositol", "5-phosphatase", "C0028860#ent", "<e1>", "are", "responsible", "for", "Lowe", "syndrome", "whose", "manifestations", "include", "mental", "retardation", "C0341703#ent", "<e2>"], "h": {"id": "C0028860", "name": "C0028860#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0341703", "name": "C0341703#ent", "pos": [17, 18]}}
{"token": ["N-beta-(4-Hydroxyphenethyl)-VDS", ",", "envisaged", "as", "a", "substrate", "for", "the", "enzyme", "tryosinase", ",", "was", "shown", "to", "be", "more", "active", "than", "C0042682#ent", "<e1>", "against", "the", "B16", "melanoma", "has", "only", "marginal", "activity", "the", "C1415112#ent", "<e2>", "."], "h": {"id": "C0042682", "name": "C0042682#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1415112", "name": "C1415112#ent", "pos": [29, 30]}}
{"token": ["The", "significant", "reduction", "in", "spontaneous", "panic", "attacks", "the", "blockade", "of", "lactate-induced", "C2945698#ent", "<e1>", "valproate", "support", "earlier", "studies", "suggesting", "that", "the", "C1254351#ent", "<e2>", "may", "be", "an", "effective", "treatment", "for", "panic", "disorder"], "h": {"id": "C2945698", "name": "C2945698#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [20, 21]}}
{"token": ["Quantitative", "real-time", "PCR", "analysis", "early", "reverse", "transcription", "products", "that", "C0121925#ent", "<e1>", "used", "the", "HIV-2", "C1823521#ent", "<e2>", "."], "h": {"id": "C0121925", "name": "C0121925#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [14, 15]}}
{"token": ["It", "is", "concluded", "that", "in", "nominally", "bicarbonate-free", "saline", ",", "the", "amiloride-sensitive", "Na+/H+", "antiport", "is", "the", "predominant", "mechanism", "of", "C1333690#ent", "<e1>", "regulation", "at", "C2975867#ent", "<e2>", "while", "being", "relatively", "inactive", "at", "physiological", "values", "C1333690#ent", "<e1>", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2975867", "name": "C2975867#ent", "pos": [22, 23]}}
{"token": ["C1333690#ent", "<e1>", "has", "been", "identified", "as", "phosphohexose", "isomerase", "C2975867#ent", "<e2>", ")", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2975867", "name": "C2975867#ent", "pos": [8, 9]}}
{"token": ["In", "addition", "to", "such", "expected", "effects", ",", "C0764784#ent", "<e1>", "had", "the", "ability", "to", "prevent", "glutamate", "neurotoxicity", "to", "promote", "the", "C1420257#ent", "<e2>", "serum-deprived", "medium", "and", "to", "prevent", "nitric", "oxide-induced", "neurotoxicity", "."], "h": {"id": "C0764784", "name": "C0764784#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [19, 20]}}
{"token": ["The", "progression", "of", "Creutzfeldt-Jakob", "disease", "C0022336#ent", "<e1>", ")", "was", "studied", "in", "ddY", "mice", "infected", "intraperitoneally", "with", "the", "Fukuoka-1", "strain", ",", "a", "C0162534#ent", "<e2>", "isolated", "from", "a", "C0022336#ent", "<e1>", "patient", "in", "Japan", "."], "h": {"id": "C0162534", "name": "C0162534#ent", "pos": [21, 22]}, "relation": "nichd_parent_of", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [5, 6]}}
{"token": ["Lipogenic", "capacity", "from", "glucose", "and", "enzymes", "normally", "associated", "with", "lipogenesis", "(", "malic", "enzyme", "C3815504#ent", "<e1>", "enzyme", "and", "glucose-6-PO4", "C0024544#ent", "<e2>", ")", "followed", "the", "same", "pattern", "of", "development", "."], "h": {"id": "C3815504", "name": "C3815504#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [18, 19]}}
{"token": ["The", "importance", "of", "the", "C0014442#ent", "<e1>", "male", "steroid", "hormone", "physiology", "is", "underscored", "by", "the", "C0037277#ent", "<e2>", "beta-HSD", "deficiency"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [14, 15]}}
{"token": ["Expression", "of", "a", "beta-glucuronidase", "gene", "by", "the", "LAT", "promoter", "was", "tested", "in", "mice", "lacking", "this", "C0014442#ent", "<e1>", ",", "which", "are", "a", "model", "for", "a", "human", "C0037277#ent", "<e2>", "the", "CNS", "(", "mucopolysaccharidosis", "VII", "Sly", "disease", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [25, 26]}}
{"token": ["Inherited", "deficiency", "this", "C0014442#ent", "<e1>", "causes", "the", "human", "C0037277#ent", "<e2>", "hereditary", "coproporphyria"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "review", "recent", "advances", "in", "knowledge", "about", "C1417679#ent", "<e1>", "associated", "with", "recessive", "PD", "including", "parkin", ",", "PINK1", ",", "and", "C3541418#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541418", "name": "C3541418#ent", "pos": [21, 22]}}
{"token": ["Advanced", "HIV", "stage", "sex", ",", "time", "from", "diagnosis", ",", "current", "CD4", "count", "C1424729#ent", "<e1>", "did", "not", "seem", "to", "affect", "the", "prevalence", "of", "C1414174#ent", "<e2>", "."], "h": {"id": "C1424729", "name": "C1424729#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414174", "name": "C1414174#ent", "pos": [22, 23]}}
{"token": ["We", "have", "implemented", "a", "suspended", "C0263505#ent", "<e1>", "transmission", "photocathode", "(", "160", "A", "thick", ")", "on", "a", "C4283801#ent", "<e2>", "and", "are", "evaluating", "it", "using", "a", "1.5", "keV", "Al", "K", "alpha", "x-ray", "source", "."], "h": {"id": "C0263505", "name": "C0263505#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [16, 17]}}
{"token": ["The", "C1448777#ent", "<e1>", "TAPP", ")", "is", "related", "to", "the", "serine/threonine", ",", "type", "1", "C1956003#ent", "<e2>", "PP1", ")", "family", "."], "h": {"id": "C1448777", "name": "C1448777#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1956003", "name": "C1956003#ent", "pos": [13, 14]}}
{"token": ["Depletion", "of", "Bcl-xL", "and", "Bcl-w", "decreases", "the", "remaining", "C1448777#ent", "<e1>", "activity", "and", "association", "of", "C1956003#ent", "<e2>", "to", "Bad", "."], "h": {"id": "C1448777", "name": "C1448777#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1956003", "name": "C1956003#ent", "pos": [14, 15]}}
{"token": ["The", "profile", "of", "interaction", "of", "C0017789#ent", "<e1>", "with", "these", "antiepileptic", "agents", "that", "of", "C0029904#ent", "<e2>", ",", "and", "differs", "considerably", "from", "the", "profiles", "of", "other", "convulsants", "previously", "tested", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [13, 14]}}
{"token": ["Taurine", "also", "abolished", "the", "after-hyperpolarization", "induced", "by", "C0017789#ent", "<e1>", "and", "this", "was", "reduced", "by", "C0029904#ent", "<e2>", "or", "lithium", "ions"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [14, 15]}}
{"token": ["Glutamine", "uptake", "is", "Na+-independent", "and", "unaffected", "by", "the", "Na+-K+-ATPase", "inhibitor", "C0029904#ent", "<e1>", ",", "whereas", "C0017789#ent", "<e2>", "uptake", "is", "Na+-dependent", "and", "inhibited", "by", "C0029904#ent", "<e1>", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [10, 11]}}
{"token": ["Despite", "concurrent", "C0015397#ent", "<e1>", "such", "as", "cataract", "and", "possible", "C0002418#ent", "<e2>", ",", "an", "improved", "overall", "visual", "function", "reported", "in", "5", "of", "the", "11", "patients", "(", "45.5", "%", ")", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0002418", "name": "C0002418#ent", "pos": [9, 10]}}
{"token": ["This", "report", "concerns", "the", "gastric", "manifestation", "Wegener's", "granulomatosis", "a", "44", "year", "old", "white", "female", "patient", "who", "initially", "presented", "with", "C0000737#ent", "<e1>", "vomiting", ",", "and", "C1510449#ent", "<e2>", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1510449", "name": "C1510449#ent", "pos": [24, 25]}}
{"token": ["In", "the", "human", "C3888088#ent", "<e1>", "there", "was", "a", "40", "%", "increase", "in", "C0028928#ent", "<e2>", "total", "lipids", ",", "while", "the", "rise", "in", "[3H]triacylglycerol", "ranged", "between", "60", "-", "90", "%", "."], "h": {"id": "C3888088", "name": "C3888088#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [12, 13]}}
{"token": ["C0009074#ent", "<e1>", "prompt", "and", "sustained", "eradication", "of", "the", "patient's", "C0014868#ent", "<e2>"], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014868", "name": "C0014868#ent", "pos": [9, 10]}}
{"token": ["Part", "of", "an", "apparent", "open", "reading", "frame", "in", "the", "tox-argK", "gene", "cluster", "of", "Pseudomonas", "syringae", "pathovar", "phaseolicola", "(", "C1537379#ent", "<e1>", ")", "potentially", "encodes", "a", "polypeptide", "with", "sequence", "similarity", "C0015680#ent", "<e2>", "DES", ")", "."], "h": {"id": "C1537379", "name": "C1537379#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0015680", "name": "C0015680#ent", "pos": [28, 29]}}
{"token": ["A", "69-year-old", "man", "developed", "an", "episode", "of", "severe", "C0206171#ent", "<e1>", "months", "after", "resection", "of", "C0276651#ent", "<e2>", "."], "h": {"id": "C0206171", "name": "C0206171#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0276651", "name": "C0276651#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", "to", "C1705325#ent", "<e1>", "blockage", "of", "Rho", "kinase", "ROCK", ")", "by", "C0667301#ent", "<e2>", "upregulated", "both", "nicotine-", "and", "E.", "coli-mediated", "cellular", "responses", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0667301", "name": "C0667301#ent", "pos": [12, 13]}}
{"token": ["Direct", "bony", "invasion", "tumour", "cells", "than", "humorally", "mediated", "C0020437#ent", "<e1>", "is", "probably", "the", "most", "common", "cause", "of", "C0149911#ent", "<e2>"], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0149911", "name": "C0149911#ent", "pos": [17, 18]}}
{"token": ["Administration", "of", "NaF", ",", "NaCl", ",", "and", "mammalian", "calcitonin", "resulted", "in", "varying", "degree", "of", "C0020437#ent", "<e1>", "and", "hyperphosphataemia", ",", "whereas", "C0149911#ent", "<e2>", "and", "hypophosphataemia", "developed", "during", "CaCl2", "treatment", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0149911", "name": "C0149911#ent", "pos": [20, 21]}}
{"token": ["Main", "cause", "of", "hypercalcemia", "associated", "with", "cancer", "is", "local", "C0020437#ent", "<e1>", "LOH", ")", "due", "to", "bone", "metastasis", "humoral", "hypercalcemia", "malignancy", "(", "C0149911#ent", "<e2>", ")", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0149911", "name": "C0149911#ent", "pos": [21, 22]}}
{"token": ["We", "describe", "our", "findings", "in", "a", "C2751824#ent", "<e1>", "female", "with", "a", "clinical", "features", "of", "C1853566#ent", "<e2>", "GPS", ")", "and", "confirmed", "hermaphroditism", "with", "ovotestes", ",", "and", "five", "additional", "patients", "with", "GPS", "."], "h": {"id": "C2751824", "name": "C2751824#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1853566", "name": "C1853566#ent", "pos": [14, 15]}}
{"token": ["The", "computed", "tomographic", "findings", "of", "C0497156#ent", "<e1>", "tracheal", "and", "bronchial", "stenosis", "associated", "with", "C3495801#ent", "<e2>", "reported", "in", "a", "young", "patient", "whose", "disease", "appeared", "limited", "to", "the", "airways", "and", "sinuses", "."], "h": {"id": "C0497156", "name": "C0497156#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3495801", "name": "C3495801#ent", "pos": [13, 14]}}
{"token": ["C2697944#ent", "<e1>", "had", "no", "effect", "the", "synthesis", "and", "secretion", "of", "C0017860#ent", "<e2>", "and", "phospholipids", "in", "the", "form", "of", "very", "low", "density", "lipoproteins", "VLDL", ")", "."], "h": {"id": "C2697944", "name": "C2697944#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [10, 11]}}
{"token": ["Our", "data", "constitute", "the", "first", "demonstration", "that", "Rac1", "and", "C1366537#ent", "<e1>", "control", "pathways", "require", "simultaneous", "signalling", "through", "MAPK", "C0752312#ent", "<e2>", "and", "p53", "to", "induce", "apoptosis", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [18, 19]}}
{"token": ["Coexpression", "of", "dominant", "negative", "C1366537#ent", "<e1>", "and", "kinase-defective", "p21-activated", "kinase", "1", "MAPK", "kinase", "7", "JNK", "and", "C0752312#ent", "<e2>", "indicated", "that", "specific", "activation", "of", "JNK", "by", "GnRH", "appears", "to", "involve", "these", "signaling", "molecules"], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [16, 17]}}
{"token": ["These", "data", "suggest", "that", "the", "C1334133#ent", "<e1>", "tyrosine-specific", "protein", "kinase", "activity", "be", "regulated", "by", "unique", "endogenous", "basic", "C0086376#ent", "<e2>", "that", "are", "distinct", "from", "those", "which", "modify", "the", "IGF-1", "receptor"], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}}
{"token": ["No", "patient", "with", "valve", "replacement", "inactive", "infective", "endocarditis", "C4288846#ent", "<e1>", "a", "single", "case", "of", "C4288846#ent", "<e1>", "in", "a", "patient", "with", "C1541923#ent", "<e1>"], "h": {"id": "C4288846", "name": "C4288846#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1541923", "name": "C1541923#ent", "pos": [20, 21]}}
{"token": ["Recent", "discoveries", "suggest", "that", "several", "C0033640#ent", "<e1>", "rapidly", "activated", "in", "response", "to", "ligand", "binding", "to", "cytoplasmic", "steroid", "hormone", "receptors", "C1419767#ent", "<e2>", ")", ",", "including", "progesterone", "receptors", "PRs", ")", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419767", "name": "C1419767#ent", "pos": [19, 20]}}
{"token": ["These", "results", "thus", "identify", "and", "characterize", "a", "series", "of", "C0907533#ent", "<e1>", "nuclear", "protein-binding", "sites", "within", "the", "second", "rat", "C1334089#ent", "<e2>", "promoter", "that", "may", "be", "involved", "in", "mediating", "its", "transcriptional", "activity"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [18, 19]}}
{"token": ["There", "is", "recent", "evidence", "that", "MC3T3-E1", "cells", "C0907533#ent", "<e1>", "produce", "and", "secrete", "insulin-like", "growth", "factor", "I", "C1334089#ent", "<e2>", ")", "and", "possess", "IGF-I", "receptors"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [16, 17]}}
{"token": ["These", "data", "suggest", "that", "C0376622#ent", "<e1>", "promoter", "transcription", "be", "regulated", "by", "PKC-alpha", "and", "C0752501#ent", "<e2>", "."], "h": {"id": "C0376622", "name": "C0376622#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752501", "name": "C0752501#ent", "pos": [13, 14]}}
{"token": ["C0897757#ent", "<e1>", "reductive", "metabolism", "observed", "when", "C0070220#ent", "<e2>", "was", "incubated", "with", "mouse", "microsomal", "preparations", "."], "h": {"id": "C0897757", "name": "C0897757#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0070220", "name": "C0070220#ent", "pos": [6, 7]}}
{"token": ["However", ",", "optimum", "selectivity", "is", "provided", "by", "a", "combination", "of", "DMI", "and", "C0028277#ent", "<e1>", "in", "animals", "anaesthetized", "with", "a", "combination", "of", "C0039925#ent", "<e2>", "and", "ketamine", "."], "h": {"id": "C0028277", "name": "C0028277#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [21, 22]}}
{"token": ["IgG", "therapy", "used", "to", "treat", "C0023530#ent", "<e1>", "in", "2", "male", "neonates", "of", "mothers", "with", "C0014060#ent", "<e2>", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [14, 15]}}
{"token": ["Cidofovir", "and", "foscarnet", "combination", "therapy", "be", "beneficial", "for", "reducing", "mortality", "of", "(", "C0023530#ent", "<e1>", ")", "stem", "cell", "transplant", "recipients", "with", "human", "herpesvirus", "C0014060#ent", "<e2>", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [22, 23]}}
{"token": ["It", "has", "been", "reported", "that", "some", "patients", "develop", "functional", "C0012242#ent", "<e1>", "particularly", "irritable", "bowel", "syndrome", "IBS", ")", ",", "after", "C0017160#ent", "<e2>", "AGE", ")", "."], "h": {"id": "C0012242", "name": "C0012242#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0017160", "name": "C0017160#ent", "pos": [19, 20]}}
{"token": ["The", "C0002763#ent", "<e1>", "picrotoxin", "antagonized", "the", "loss", "of", "righting", "reflex", "by", "C0031412#ent", "<e2>", ",", "but", "nikethamide", ",", "caffeine", "and", "strychnine", "did", "not", "alter", "the", "depressant", "effects", "of", "phenobarbitone.4", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [11, 12]}}
{"token": ["p53", "and", "MNK/Chk2", "also", "regulate", "C1333237#ent", "<e1>", "including", "two", "components", "of", "the", "nonhomologous", "end-joining", "repair", "pathway", "C1311257#ent", "<e2>", "and", "Ku80", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1311257", "name": "C1311257#ent", "pos": [16, 17]}}
{"token": ["The", "most", "common", "causes", "of", "C0264573#ent", "<e1>", "generally", "considered", "to", "be", "granulomatous", "diseases", "especially", "C0019655#ent", "<e2>", ",", "although", "many", "other", "causes", "have", "also", "been", "suggested", "."], "h": {"id": "C0264573", "name": "C0264573#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [14, 15]}}
{"token": ["Phospholipase", "C-dependent", "hydrolysis", "of", "C0136804#ent", "<e1>", "significantly", "enhanced", "by", "C1540100#ent", "<e2>", "and", "atropine", ",", "but", "not", "by", "dyflos", "."], "h": {"id": "C0136804", "name": "C0136804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1540100", "name": "C1540100#ent", "pos": [9, 10]}}
{"token": ["Hyperimmunoglobulinemia", "D", "syndrome", "C0398691#ent", "<e1>", ")", "is", "newly", "recognized", "and", "resembles", "C0031069#ent", "<e2>", "FMF", ")", "."], "h": {"id": "C0398691", "name": "C0398691#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [11, 12]}}
{"token": ["The", "C0398691#ent", "<e1>", "distinct", "from", "other", "periodic", "fever", "syndromes", "systemic-onset", "juvenile", "rheumatoid", "arthritis", "adult-onset", "Still", "disease", "and", "C0031069#ent", "<e2>"], "h": {"id": "C0398691", "name": "C0398691#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "C0006277#ent", "<e1>", "in", "a", "58", "year-old", "man", "free", "from", "underlying", "C0024115#ent", "<e2>"], "h": {"id": "C0006277", "name": "C0006277#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [15, 16]}}
{"token": ["C0006277#ent", "<e1>", "accounted", "for", "over", "50", "%", "of", "the", "C0024115#ent", "<e2>", "cases", "among", "this", "cohort", "followed", "by", "asthma", ",", "chronic", "obstructive", "airway", "disease", "and", "chronic", "bronchitis"], "h": {"id": "C0006277", "name": "C0006277#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [9, 10]}}
{"token": ["We", "studied", "the", "effects", "of", "C0812246#ent", "<e1>", "on", "cloned", "HERG", "K(+", ")", "channel", "(", "human", "C1425833#ent", "<e2>", "in", "HEK293", "cells", "native", "I(Kr", ")", "in", "canine", "cardiomyocytes", "with", "whole-cell", "patch", "clamp", "techniques"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425833", "name": "C1425833#ent", "pos": [15, 16]}}
{"token": ["Beta-site", "APP", "cleaving", "enzyme", "1", "C1412727#ent", "<e1>", ")", "is", "the", "major", "C1569775#ent", "<e2>", "in", "vivo"], "h": {"id": "C1412727", "name": "C1412727#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1569775", "name": "C1569775#ent", "pos": [11, 12]}}
{"token": ["C1412727#ent", "<e1>", "is", "the", "major", "C1569775#ent", "<e2>", "to", "cleave", "the", "beta-amyloid", "precursor", "protein", "APP", ")", "to", "generate", "A(beta", ")", "."], "h": {"id": "C1412727", "name": "C1412727#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1569775", "name": "C1569775#ent", "pos": [5, 6]}}
{"token": ["However", ",", "C0017601#ent", "<e1>", "ciliary", "block", ")", "may", "complicate", "trabeculectomy", "in", "cases", "with", "C0017606#ent", "<e2>"], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017606", "name": "C0017606#ent", "pos": [13, 14]}}
{"token": ["There", "exist", "several", "other", "TNF", "antagonists", "in", "various", "phases", "of", "investigation", ",", "including", "the", "monoclonal", "antibody", "CDP", "571", ",", "the", "C0030956#ent", "<e1>", "etanercept", ",", "the", "phosphodiesterase", "inhibitor", "C0030899#ent", "<e2>", ",", "and", "thalidomide", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0030899", "name": "C0030899#ent", "pos": [27, 28]}}
{"token": ["This", "study", "indicates", "that", "C0065175#ent", "<e1>", "may", "circumvent", "clinical", "resistance", "EPI", "without", "C2712370#ent", "<e2>", "the", "pattern", "or", "severity", "of", "the", "toxicity", "of", "this", "anthracycline", "."], "h": {"id": "C0065175", "name": "C0065175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [12, 13]}}
{"token": ["This", "study", "indicates", "that", "C0065175#ent", "<e1>", "may", "circumvent", "clinical", "resistance", "some", "cases", "without", "C2712370#ent", "<e2>", "chemotherapy", "related", "toxicity", "."], "h": {"id": "C0065175", "name": "C0065175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "C0072476#ent", "<e1>", "has", "been", "shown", "to", "enhance", "the", "activities", "of", "C3890353#ent", "<e2>", ",", "c-Myb", "and", "cdc25a", ",", "and", "in", "part", "this", "might", "explain", "reported", "effects", "on", "mitogenesis", "."], "h": {"id": "C0072476", "name": "C0072476#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3890353", "name": "C3890353#ent", "pos": [12, 13]}}
{"token": ["C0072476#ent", "<e1>", "phosphorylated", "p100", "in", "vitro", "formed", "a", "stable", "complex", "with", "C3890353#ent", "<e2>", "in", "animal", "cells", "and", "functioned", "downstream", "of", "Ras", "to", "stimulate", "c-Myb", "transcriptional", "activity", "in", "a", "p100-dependent", "manner", "."], "h": {"id": "C0072476", "name": "C0072476#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890353", "name": "C3890353#ent", "pos": [11, 12]}}
{"token": ["Using", "a", "yeast", "two-hybrid", "screen", "we", "found", "that", "C0072476#ent", "<e1>", "binds", "to", "C3890353#ent", "<e2>", ",", "a", "transcriptional", "coactivator", "interacts", "with", "the", "c-Myb", "transcription", "factor"], "h": {"id": "C0072476", "name": "C0072476#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3890353", "name": "C3890353#ent", "pos": [12, 13]}}
{"token": ["We", "suggest", "that", "cell", "pathways", "by", "some", "C1421249#ent", "<e1>", "be", "involved", "in", "the", "pathogenesis", "of", "these", "C0015230#ent", "<e2>"], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [16, 17]}}
{"token": ["The", "results", "show", "that", "in", "human", "cells", "C0077845#ent", "<e1>", "NEIL1", "excises", "the", "MAs", "in", "duplex", "DNA", "subsequently", "the", "apurinic/apyrimidinic", "endonuclease", "1", "C1332102#ent", "<e2>", ",", "removes", "the", "3'-phosphate", "residue", "at", "single-strand", "break", "by", "NEIL1", "."], "h": {"id": "C0077845", "name": "C0077845#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332102", "name": "C1332102#ent", "pos": [21, 22]}}
{"token": ["The", "goals", "of", "our", "study", "were", "the", "development", "of", "a", "quantitative", "polymerase", "chain", "reaction", "angiotensin", "II", "receptor", "type", "1", "mRNA", "to", "determine", "the", "angiotensin", "receptor", "type", "1", "C1439284#ent", "<e1>", ")", "mRNA", "content", "in", "the", "atria", "of", "patients", "with", "C2316810#ent", "<e2>"], "h": {"id": "C1439284", "name": "C1439284#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [38, 39]}}
{"token": ["We", "reported", "a", "case", "of", "C0041316#ent", "<e1>", "by", "the", "development", "of", "pulmonary", "lesions", "recurrent", "C1404574#ent", "<e2>"], "h": {"id": "C0041316", "name": "C0041316#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1404574", "name": "C1404574#ent", "pos": [14, 15]}}
{"token": ["The", "nucleotide", "preference", "ratio", "(", "C1366909#ent", "<e1>", ")", "for", "eEF1A-1", "was", "0.82", ",", "while", "the", "preference", "ratio", "C1705443#ent", "<e2>", "was", "1.50", "."], "h": {"id": "C1366909", "name": "C1366909#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705443", "name": "C1705443#ent", "pos": [17, 18]}}
{"token": ["The", "results", "obtained", "from", "this", "study", "suggested", "that", "C3541971#ent", "<e1>", "in", "green", "tea", "play", "a", "role", "to", "increase", "the", "C0007246#ent", "<e2>", "cooperation", "with", "other", "components", "in", "tea", "."], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007246", "name": "C0007246#ent", "pos": [19, 20]}}
{"token": ["The", "inclusion", "of", "pyrophosphate", "in", "a", "C3541971#ent", "<e1>", "containing", "dentifrice", "did", "not", "interfere", "with", "the", "C0007246#ent", "<e2>", "C3541971#ent", "<e1>", "on", "tooth", "enamel"], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007246", "name": "C0007246#ent", "pos": [15, 16]}}
{"token": ["Emphasis", "was", "layed", "on", "psychophysiologic", "insomnia", "C1834372#ent", "<e1>", ",", "sleep", "apnea", "syndrome", "periodic", "legs", "movements", "in", "sleep", ",", "C3888109#ent", "<e2>", "on", "insomnia", "within", "circadian", "dysregulation", "."], "h": {"id": "C1834372", "name": "C1834372#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3888109", "name": "C3888109#ent", "pos": [18, 19]}}
{"token": ["The", "diagnostic", "categories", "are", ":", "sleep-related", "breathing", "disorders", "other", "respiratory", "disorders", "C1834372#ent", "<e1>", ";", "parasomnias", "and", "sleep-related", "epilepsy", "C3888109#ent", "<e2>", "periodic", "limb", "movement", "disorders", "insomnia", ";", "and", "circadian", "rhythm", "sleep", "disorders"], "h": {"id": "C1834372", "name": "C1834372#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3888109", "name": "C3888109#ent", "pos": [18, 19]}}
{"token": ["Only", "2", "cases", "of", "C0019163#ent", "<e1>", "infection", "and", "3", "of", "C1839163#ent", "<e2>", "were", "observed", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [10, 11]}}
{"token": ["In", "conclusion", ",", "observed", "tissue-specific", "differences", "the", "chromatin", "structure", "correlate", "with", "tissue-specific", "promoter", "activity", "that", "C0008546#ent", "<e1>", "might", "be", "an", "important", "regulator", "of", "C0003805#ent", "<e2>", "expression", "in", "cattle", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [23, 24]}}
{"token": ["We", "observed", "that", "poly(ADP-ribose)", "polymerase", "1", "C1709384#ent", "<e1>", ")", ",", "one", "of", "the", "major", "nuclear", "targets", "for", "C0534519#ent", "<e2>", ",", "was", "proteolytically", "degraded", "generating", "primarily", "64", "and", "54", "kDa", "fragments", "."], "h": {"id": "C1709384", "name": "C1709384#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [17, 18]}}
{"token": ["Reconstitution", "in", "yeast", "confirmed", "that", "C2713011#ent", "<e1>", "acts", "on", "the", "pathway", "and", "overcomes", "BCL-2-", ",", "C1332397#ent", "<e2>", ",", "BCL-w-", ",", "and", "MCL-1-mediated", "resistance", "to", "BAX", "or", "BAK", "."], "h": {"id": "C2713011", "name": "C2713011#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [15, 16]}}
{"token": ["Twenty", "Bedouin", "had", "C0018784#ent", "<e1>", "was", "thought", "to", "be", "C3899988#ent", "<e2>", "one", "family", "grouping"], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}}
{"token": ["Primary", "distal", "renal", "tubular", "acidosis", "with", "C0018784#ent", "<e1>", "a", "rare", "C3899988#ent", "<e2>", "usually", "caused", "by", "mutations", "in", "the", "ATP6V1B1", "gene"], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [10, 11]}}
{"token": ["If", "variation", "in", "C0025209#ent", "<e1>", "is", "a", "polymorphism", ",", "its", "expression", "should", "be", "C1516876#ent", "<e2>", "determined", "and", "fitness", "of", "melanin-based", "variants", "equal", "."], "h": {"id": "C0025209", "name": "C0025209#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [13, 14]}}
{"token": ["All", "five", "C1537379#ent", "<e1>", "sons", "inherited", "the", "C3812180#ent", "<e2>", "the", "eight", "healthy", "sons", "each", "inherited", "the", "A20", "allele", "."], "h": {"id": "C1537379", "name": "C1537379#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3812180", "name": "C3812180#ent", "pos": [7, 8]}}
{"token": ["These", "C0035064#ent", "<e1>", "did", "not", "affect", "cellular", "adenosine", "triphosphate", "ATP", ")", "levels", "but", "inhibited", "C1865361#ent", "<e2>", "activity", "in", "HepG2", "and", "HuH-7", "cells", "when", "added", "to", "their", "protein", "extracts", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1865361", "name": "C1865361#ent", "pos": [14, 15]}}
{"token": ["We", "have", "now", "tested", "a", "candidate", "interactor", "protein", "PINK1", ",", "the", "C1826325#ent", "<e1>", "MTIF3", ")", "for", "involvement", "in", "C3160718#ent", "<e2>", "pathogenesis", "."], "h": {"id": "C1826325", "name": "C1826325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [18, 19]}}
{"token": ["At", "least", "15", "different", "alpha-carbonic", "anhydrase", "CA", ",", "C1311420#ent", "<e1>", "isoforms", "were", "isolated", "in", "mammals", ",", "where", "these", "zinc", "C3540790#ent", "<e2>", "play", "crucial", "physiological", "roles"], "h": {"id": "C1311420", "name": "C1311420#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [19, 20]}}
{"token": ["These", "specificities", "are", "determined", "by", "the", "tissue", "distribution", "of", "the", "C0597298#ent", "<e1>", "beta1", ",", "the", "structure", "of", "the", "thyroid", "hormone", "response", "element", "C1421114#ent", "<e2>", ")", "bound", "by", "the", "receptor", ",", "and", "heterodimerization", "partners", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [22, 23]}}
{"token": ["Finally", ",", "PHOX2B", "proteins", "mutations", "responsible", "for", "C0007965#ent", "<e1>", "(", "congenital", "central", "hypoventilation", "syndrome", "development", "showed", "a", "severe", "impairment", "in", "activating", "C1418596#ent", "<e2>", "expression", ",", "both", "in", "vitro", "in", "vivo"], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418596", "name": "C1418596#ent", "pos": [21, 22]}}
{"token": ["In", "addition", "to", "progressive", "gait", "ataxia", "action", "tremor", "C0031117#ent", "<e1>", "and", "parkinsonism", ",", "C1839780#ent", "<e2>", "involves", "impaired", "cognition", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C1839780", "name": "C1839780#ent", "pos": [13, 14]}}
{"token": ["C0031117#ent", "<e1>", "common", "among", "patients", "with", "C1839780#ent", "<e2>", "FXTAS", ")", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C1839780", "name": "C1839780#ent", "pos": [6, 7]}}
{"token": ["The", "presence", "of", "complexes", "was", "found", "in", "18", "patients", "including", "6", "out", "of", "10", "patients", "with", "C1510449#ent", "<e1>", "and", "in", "12", "out", "of", "18", "patients", "with", "C0042164#ent", "<e2>"], "h": {"id": "C1510449", "name": "C1510449#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [26, 27]}}
{"token": ["Leptospiral", "proteins", "expressed", "during", "prolonged", "survival", "in", "the", "eyes", "of", "horses", "with", "lesions", "of", "C1510449#ent", "<e1>", "identified", "by", "screening", "a", "phage", "library", "Leptospira", "interrogans", "DNA", "fragments", "eye", "fluids", "C0042164#ent", "<e2>"], "h": {"id": "C1510449", "name": "C1510449#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [28, 29]}}
{"token": ["Mean", "RPR", "titer", "in", "the", "C1510449#ent", "<e1>", "group", "and", "in", "the", "C0042164#ent", "<e2>", "group", "was", "1:27.3", "and", "1:209.8", ",", "respectively", "."], "h": {"id": "C1510449", "name": "C1510449#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [11, 12]}}
{"token": ["Thirty-seven", "patients", "with", "C1510449#ent", "<e1>", "enrolled", ":", "21", "of", "them", "had", "C0042164#ent", "<e2>", "the", "remaining", "16", "were", "in", "complete", "remission", "."], "h": {"id": "C1510449", "name": "C1510449#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [11, 12]}}
{"token": ["The", "microscopic", "examination", "of", "Gram-stained", "sputum", "specimens", "is", "very", "helpful", "in", "the", "evaluation", "of", "patients", "with", "C0206171#ent", "<e1>", "has", "also", "been", "recommended", "for", "use", "in", "C0010674#ent", "<e2>", "CF", ")", "patients", "."], "h": {"id": "C0206171", "name": "C0206171#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [25, 26]}}
{"token": ["Dislocation", "requires", "a", "subclass", "of", "C1336849#ent", "<e1>", "includes", "gp78", "in", "addition", "to", "the", "AAA", "C1706373#ent", "<e2>", "p97/VCP", "and", "its", "cofactor", ",", "the", "Ufd1-Npl4", "dimer", "."], "h": {"id": "C1336849", "name": "C1336849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [14, 15]}}
{"token": ["Thus", "the", "distinction", "between", "the", "divalent", "ion", "requirements", "for", "C1418888#ent", "<e1>", "degradation", "suggests", "that", "the", "C0033847#ent", "<e2>", "fibroblasts", "may", "produce", "a", "different", "cysteine", "protease", "do", "normal", "fibroblasts", "."], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033847", "name": "C0033847#ent", "pos": [15, 16]}}
{"token": ["Five", "C0030940#ent", "<e1>", "were", "identified", ":", "urokinase-type", "plasminogen", "activator", "factor", "XII", "C1418943#ent", "<e2>", "trypsinogen", "IV", "and", "a", "protease", "that", "we", "refer", "to", "as", "membrane-type", "serine", "protease", "1", "MT-SP1", ")", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [11, 12]}}
{"token": ["As", "well", "as", "inhibiting", "thrombin", "and", "the", "C0030940#ent", "<e1>", "the", "Pittsburgh", "mutant", "also", "inhibits", "activated", "protein", "Inhibition", "of", "the", "C1418943#ent", "<e2>", "known", "to", "exacerbate", "septic", "shock"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [19, 20]}}
{"token": ["C7", "-", "14", "and", "C1412521#ent", "<e1>", "-", "15", "are", "subclones", "from", "the", "original", "C1367714#ent", "<e2>", "sensitive", "to", "apoptosis", "by", "glucocorticoids", ")", "and", "C1412521#ent", "<e1>", "(", "resistant", ")", "."], "h": {"id": "C1367714", "name": "C1367714#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412521", "name": "C1412521#ent", "pos": [4, 5]}}
{"token": ["The", "human", "homologue", "of", "C1705781#ent", "<e1>", ",", "the", "human", "melanoma", "proteoglycan", "C3889382#ent", "<e2>", ")", ",", "is", "expressed", "on", "most", "human", "melanomas", "."], "h": {"id": "C1705781", "name": "C1705781#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889382", "name": "C3889382#ent", "pos": [11, 12]}}
{"token": ["Small", "doses", "C0040373#ent", "<e1>", "or", "yohimbine", "rapidly", "antagonized", "the", "effects", "of", "C0009014#ent", "<e2>", "but", "not", "5-HTP", "."], "h": {"id": "C0040373", "name": "C0040373#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [11, 12]}}
{"token": ["In", "C0035435#ent", "<e1>", "a", "predominance", "of", "a", "C3540579#ent", "<e2>", "immune", "response", "a", "shift", "to", "a", "Th2", "type", "immune", "response", "pregnancy", "has", "been", "regarded", "as", "beneficial", "."], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [7, 8]}}
{"token": ["Injecting", "WGA-HRP", "into", "the", "abducens", "nucleus", "the", "surrounding", "tissue", "labeled", "cells", "in", "SC", ",", "C1367307#ent", "<e1>", ",", "MVN", ",", "FN", ",", "and", "nucleus", "prepositus", "hypoglossi", "C0020258#ent", "<e2>", ")", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020258", "name": "C0020258#ent", "pos": [25, 26]}}
{"token": ["C3273481#ent", "<e1>", "is", "an", "C0021699#ent", "<e2>", "a", "single", "transmembrane", "domain", "close", "to", "its", "C", "terminus", "."], "h": {"id": "C3273481", "name": "C3273481#ent", "pos": [0, 1]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [4, 5]}}
{"token": ["The", "test", "has", "been", "applied", "to", "viral", "(", "hog", "cholera", ",", "parasitic", "(", "C0040896#ent", "<e1>", ")", ",", "and", "bacterial", "(", "brucellosis", ")", "C0012634#ent", "<e2>", "of", "animals", "."], "h": {"id": "C0040896", "name": "C0040896#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}}
{"token": ["Cicatricial", "entropion", "C0040896#ent", "<e1>", "may", "be", "caused", "by", "a", "variety", "of", "C0012634#ent", "<e2>", ",", "of", "which", "trachomatous", "entropion", "is", "the", "commonest", "worldwide", "."], "h": {"id": "C0040896", "name": "C0040896#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["Overexpression", "of", "C0694888#ent", "<e1>", "also", "increased", "acid", "sphingomyelinase", "C0037903#ent", "<e2>", ")", "activity", "."], "h": {"id": "C0694888", "name": "C0694888#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037903", "name": "C0037903#ent", "pos": [8, 9]}}
{"token": ["Human", "peripheral", "blood", "B", "cells", "stimulated", "with", "anti-CD3-activated", "T", "cells", "or", "the", "Wood", "46", "strain", "of", "Staphylococcus", "aureus", "which", "lacks", "C1420002#ent", "<e1>", ",", "expressed", "IgM", "containing", "all", "C1420224#ent", "<e2>", "families", ",", "as", "detected", "by", "reverse", "transcription-PCR"], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1420224", "name": "C1420224#ent", "pos": [27, 28]}}
{"token": ["We", "report", "a", "case", "where", "trichothiodystrophy", "was", "associated", "with", "abnormalities", "of", "the", "nails", ",", "teeth", "and", "C0235267#ent", "<e1>", ",", "growth", "and", "mental", "retardation", "C0019537#ent", "<e2>", "hypogonadism", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0019537", "name": "C0019537#ent", "pos": [23, 24]}}
{"token": ["FGF2", "specifically", "induced", "expression", "of", "PC-1", "and", "C2827376#ent", "<e1>", "while", "inhibiting", "expression", "of", "C1412364#ent", "<e2>", ",", "at", "both", "mRNA", "and", "protein", "levels"], "h": {"id": "C2827376", "name": "C2827376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412364", "name": "C1412364#ent", "pos": [13, 14]}}
{"token": ["NPP1", "and", "C2827376#ent", "<e1>", "increase", "PPi", "concentration", "in", "the", "extracellular", "matrix", "while", "C1412364#ent", "<e2>", "hydrolyzes", "PPi", "."], "h": {"id": "C2827376", "name": "C2827376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412364", "name": "C1412364#ent", "pos": [12, 13]}}
{"token": ["Insulin", "receptor", "substrate", "p53", "IRSp53", ")", "is", "a", "key", "player", "in", "C1333200#ent", "<e1>", "dynamics", ",", "interacting", "with", "the", "actin", "modulators", "C4084757#ent", "<e2>", "and", "Mena", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4084757", "name": "C4084757#ent", "pos": [20, 21]}}
{"token": ["Considering", "these", "specific", "clinical", "and", "neuropathological", "findings", "C1418270#ent", "<e1>", "seems", "to", "constitute", "one", "C0012634#ent", "<e2>"], "h": {"id": "C1418270", "name": "C1418270#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "the", "autosomal", "recessive", "type", "of", "JP", "C1418270#ent", "<e1>", ")", "was", "confirmed", "to", "be", "a", "C0012634#ent", "<e2>", "the", "detection", "of", "an", "abnormality", "of", "the", "'", "parkin'", "gene"], "h": {"id": "C1418270", "name": "C1418270#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [16, 17]}}
{"token": ["When", "the", "density", "exceeded", "6", "X", "10(5", ")", "C0669372#ent", "<e1>", "per", "dish", ",", "the", "number", "of", "C0035379#ent", "<e2>", "colonies", "markedly", "declined", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [16, 17]}}
{"token": ["Separately", ",", "we", "identified", "C0661256#ent", "<e1>", "cDNA", "as", "an", "anti-cancer", "drug", "C0079429#ent", "<e2>", "in", "a", "human", "salivary", "gland", "cancer", "cell", "line", "TYS", "."], "h": {"id": "C0661256", "name": "C0661256#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["C1426113#ent", "<e1>", "belongs", "to", "the", "highly", "conserved", "Ras", "subfamily", "small", "C0242853#ent", "<e2>", "."], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [10, 11]}}
{"token": ["The", "MST1", "catalytic", "domain", "most", "C1512488#ent", "<e1>", "to", "Ste20", "and", "other", "C3814066#ent", "<e2>", "62", "-", "65", "%", "similar", ")", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3814066", "name": "C3814066#ent", "pos": [11, 12]}}
{"token": ["C0001857#ent", "<e1>", "239", "had", "no", "effect", "the", "C2987634#ent", "<e2>", "either", "strain", "."], "h": {"id": "C0001857", "name": "C0001857#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}}
{"token": ["Mutations", "in", "C1412841#ent", "<e1>", "Btk", ")", "have", "been", "associated", "with", "C0021051#ent", "<e2>", "in", "man", "and", "in", "the", "mouse", "."], "h": {"id": "C1412841", "name": "C1412841#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [10, 11]}}
{"token": ["Isoproterenol", ",", "a", "potent", "C2987634#ent", "<e1>", "of", "adenylate", "cyclase", "potentiated", "the", "actions", "of", "C-type", "natriuretic", "peptide", "of", "C0037533#ent", "<e2>"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [17, 18]}}
{"token": ["Isometric", "force", "in", "alpha(2)(-/-)-aorta", "was", "more", "sensitive", "to", "C2987634#ent", "<e1>", "less", "sensitive", "to", "the", "vasodilators", "forskolin", "C0037533#ent", "<e2>", "SNP", ")", "than", "wild-type", "(", "WT", ")", "aorta", ";", "alpha(2)(+/-)-aortas", "had", "intermediate", "values"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [16, 17]}}
{"token": ["5,8,11,14,17-Eicosapentaenoic", "acid", "(", "EPA", ")", "suppresses", "arachidonic", "acid", "C0000546#ent", "<e1>", "conversion", "by", "C1565830#ent", "<e2>", "(", "as", "well", "as", "lipoxygenase", ")", "to", "aggregatory", "metabolites", "in", "platelets", "."], "h": {"id": "C0000546", "name": "C0000546#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [12, 13]}}
{"token": ["All", "had", "disease", "involving", "the", "right", "side", "of", "the", "heart", ",", "such", "as", "mitral", "stenosis", "four", "cases", ")", ",", "congenital", "heart", "disease", "two", ")", ",", "C0034072#ent", "<e1>", "one", ")", ",", "and", "C0878544#ent", "<e2>", "one", ")", "."], "h": {"id": "C0034072", "name": "C0034072#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0878544", "name": "C0878544#ent", "pos": [31, 32]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "the", "C0019103#ent", "<e2>", "OHF", ")", "virus", "was", "cloned", "and", "sequenced", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019103", "name": "C0019103#ent", "pos": [5, 6]}}
{"token": ["The", "C1705288#ent", "<e1>", "cDNA", "has", "extensive", "sequence", "similarities", "to", "the", "C0751993#ent", "<e2>", "but", ",", "at", "variance", "with", "c-myb", ",", "it", "is", "expressed", "in", "cells", "other", "than", "hematopoietic", "cells"], "h": {"id": "C1705288", "name": "C1705288#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0751993", "name": "C0751993#ent", "pos": [10, 11]}}
{"token": ["These", "observations", "demonstrate", "a", "novel", "viral", "immunoevasive", "for", "C1419491#ent", "<e1>", ",", "and", "implicate", "the", "ER-lumenal", "domain", "of", "a", "C1335807#ent", "<e2>", "lysosomal", "sorting"], "h": {"id": "C1419491", "name": "C1419491#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335807", "name": "C1335807#ent", "pos": [18, 19]}}
{"token": ["The", "predicted", "NLS1", "(", "KRKR", ")", "was", "essential", "for", "physical", "interaction", "karyopherin", "alpha2", "C0537086#ent", "<e1>", "and", "its", "mutation", "resulted", "in", "decreased", "nuclear", "import", "C2346520#ent", "<e2>", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2346520", "name": "C2346520#ent", "pos": [23, 24]}}
{"token": ["The", "percent", "residual", "difference", "(", "C1418874#ent", "<e1>", ")", "between", "an", "unprocessed", "and", "processed", "C3714506#ent", "<e2>", "is", "used", "as", "a", "performance", "measure"], "h": {"id": "C1418874", "name": "C1418874#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714506", "name": "C3714506#ent", "pos": [13, 14]}}
{"token": ["Although", "designed", "to", "target", "only", "the", "C0079522#ent", "<e1>", "C0079522#ent", "<e1>", "inhibitors", "induce", "toxicities", "in", "patients", "such", "as", "insulin", "resistance", "C0023787#ent", "<e1>", "that", "suggest", "that", "protease", "inhibitors", "other", "targets", "in", "mammalian", "cells"], "h": {"id": "C0079522", "name": "C0079522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023787", "name": "C0023787#ent", "pos": [19, 20]}}
{"token": ["We", "first", "hypothesized", "that", "C3890553#ent", "<e1>", "may", "negatively", "regulate", "the", "C3889135#ent", "<e2>", "activity", "by", "competing", "for", "the", "ligands", ",", "bile", "acids"], "h": {"id": "C3890553", "name": "C3890553#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889135", "name": "C3889135#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "we", "investigated", "the", "role", "of", "BAs", "on", "the", "ontogenic", "expression", "of", "C3890553#ent", "<e1>", "and", "whether", "C3889135#ent", "<e2>", "may", "mediate", "these", "effects", "."], "h": {"id": "C3890553", "name": "C3890553#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3889135", "name": "C3889135#ent", "pos": [17, 18]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "in", "vitro", "potency", "of", "the", "antidepressants", "C0771310#ent", "<e1>", ",", "sertraline", "and", "fluoxetine", "in", "inhibiting", "C0085173#ent", "<e2>", "biotransformation", "."], "h": {"id": "C0771310", "name": "C0771310#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [22, 23]}}
{"token": ["Caution", "should", "be", "exercised", "in", "administering", "C0771310#ent", "<e1>", "triazolobenzodiazepines", ",", "and", "coadministration", "with", "C0085173#ent", "<e2>", "or", "astemizole", "is", "contra-indicated", "."], "h": {"id": "C0771310", "name": "C0771310#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [13, 14]}}
{"token": ["NDS", "prevented", "C0427008#ent", "<e1>", "(", "increased", "LVEDP", ")", "better", "than", "C3811816#ent", "<e2>", "during", "normethermic", "cardioplegia", "30", "min", "."], "h": {"id": "C0427008", "name": "C0427008#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3811816", "name": "C3811816#ent", "pos": [10, 11]}}
{"token": ["We", "have", "then", "coupled", "immunohistochemistry", "with", "RNA", "in", "situ", "in", "order", "to", "precisely", "identify", "the", "expression", "pattern", "of", "different", "genes", ",", "including", "C1337002#ent", "<e1>", ",", "Umod", "and", "C1420369#ent", "<e2>", "."], "h": {"id": "C1337002", "name": "C1337002#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [27, 28]}}
{"token": ["Both", "patients", "received", "5-fluorouracil", "and", "C1518775#ent", "<e1>", "one", "also", "received", "C0025677#ent", "<e2>", ",", "leucovorin", ",", "and", "triacetyluridine", "with", "the", "C1518775#ent", "<e1>", "5-fluorouracil", "."], "h": {"id": "C1518775", "name": "C1518775#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [10, 11]}}
{"token": ["Leuconostoc", "carnosum", "LA54a", "and", "TA26b", ")", "and", "Leuconostoc", "mesenteroides", "subspecies", "dextranicum", "TA33a", ")", "produced", "bacteriocins", "that", "were", "susceptible", "to", "C3540759#ent", "<e1>", "but", "not", "to", "C0007367#ent", "<e2>", ",", "lysozyme", "or", "chloroform", "."], "h": {"id": "C3540759", "name": "C3540759#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [24, 25]}}
{"token": ["They", "were", "inactivated", "by", "the", "C3540759#ent", "<e1>", "and", "proteinase", "K", "but", "not", "by", "lipase", ",", "alpha-amylase", ",", "C0007367#ent", "<e2>", "or", "lysozyme", "."], "h": {"id": "C3540759", "name": "C3540759#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [17, 18]}}
{"token": ["Normal", "factor", "IX", "complete", "activation", "in", "one", "hour", "as", "determined", "by", "measuring", "the", "increase", "in", "fluorescence", "when", "C0048024#ent", "<e1>", "bound", "to", "C0015520#ent", "<e2>"], "h": {"id": "C0048024", "name": "C0048024#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0015520", "name": "C0015520#ent", "pos": [21, 22]}}
{"token": ["Clinical", "findings", "the", "non-steroidal", "inhibitor", "C0290883#ent", "<e1>", "in", "combination", "with", "tamoxifen", "(", "C1710684#ent", "<e2>", "were", "consistent", "with", "results", "."], "h": {"id": "C0290883", "name": "C0290883#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1710684", "name": "C1710684#ent", "pos": [12, 13]}}
{"token": ["Ninety-four", "patients", "from", "the", "C0290883#ent", "<e1>", ",", "tamoxifen", "and", "combined", "(", "C1710684#ent", "<e2>", ")", "trial", "and", "35", "non-cancer", "controls", "were", "assessed", "."], "h": {"id": "C0290883", "name": "C0290883#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1710684", "name": "C1710684#ent", "pos": [11, 12]}}
{"token": ["2", ")", "Preliminary", "four-year", "results", "from", "a", "double-blind", "randomised", "controlled", "trial", "comparing", "C0290883#ent", "<e1>", "with", "tamoxifen", "(", "C1710684#ent", "<e2>", "indicated", "an", "advantage", "for", "C0290883#ent", "<e1>", "in", "reducing", "the", "risk", "of", "relapse", "."], "h": {"id": "C0290883", "name": "C0290883#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1710684", "name": "C1710684#ent", "pos": [17, 18]}}
{"token": ["From", "these", "results", "we", "conclude", "that", "C0001640#ent", "<e1>", "stimulation", "causes", "the", "increase", "in", "protein", "synthesis", "activation", "of", "C1539778#ent", "<e2>", ",", "but", "independent", "of", "the", "concomitant", "increase", "in", "creatine", "phosphate", "contents", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539778", "name": "C1539778#ent", "pos": [17, 18]}}
{"token": ["C0062637#ent", "<e1>", "abolished", "the", "C0030304#ent", "<e2>", "and", "duodenal", "peaks", "but", "not", "the", "changes", "in", "gastric", "and", "pouch", "motility", "induced", "by", "motilin", "or", "duodenal", "alkalinization"], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030304", "name": "C0030304#ent", "pos": [4, 5]}}
{"token": ["The", "effect", "of", "substrate", "or", "substrate", "analog", "binding", "on", "the", "stability", "of", "C2987364#ent", "<e1>", "MCAD", "and", "C0064095#ent", "<e2>", "i3VD", ")", "and", "their", "genetic", "mutants", "K304E-", "and", "T168A-MCAD", "and", "A282V-i3VD", ")", "is", "examined", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0064095", "name": "C0064095#ent", "pos": [16, 17]}}
{"token": ["Recombinant", "attenuated", "Salmonella", "vaccines", "avian", "coccidiosis", "were", "developed", "to", "deliver", "Eimeria", "species", "antigens", "the", "lymphoid", "tissues", "chickens", "via", "the", "C4042815#ent", "<e1>", "T3SS", ")", "and", "the", "C4042815#ent", "<e1>", "T2SS", ")", "of", "Salmonella", "."], "h": {"id": "C4042815", "name": "C4042815#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4042815", "name": "C4042815#ent", "pos": [19, 20]}}
{"token": ["Cyclooxygenase-2", "(", "C1705323#ent", "<e1>", ")", ",", "human", "synovial", "inflammatory", "phospholipase", "A2", "(", "C1418616#ent", "<e2>", ")", "and", "cytoplasmic", "phospholipase", "A2", "cPLA2", ")", "are", "involved", "in", "eicosanoid", "production", "and", "also", "seem", "to", "participate", "in", "colorectal", "tumorigenesis"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418616", "name": "C1418616#ent", "pos": [12, 13]}}
{"token": ["Amino", "acid", "identity", "between", "the", "predicted", "open", "reading", "frames", "ORFs", ")", "of", "the", "two", "C0017428#ent", "<e1>", "was", "94", "-", "100", "%", ",", "except", "for", "C3891713#ent", "<e2>", ",", "which", "had", "an", "identity", "of", "83", "%", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3891713", "name": "C3891713#ent", "pos": [24, 25]}}
{"token": ["Polymerase", "chain", "reaction", "PCR", ")", "analysis", "failed", "to", "detect", "the", "C0017428#ent", "<e1>", "of", "EBV", "and", "C3891713#ent", "<e2>", "in", "the", "abnormal", "lymphocytes", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3891713", "name": "C3891713#ent", "pos": [15, 16]}}
{"token": ["At", "day", "9", "of", "primary", "culture", "when", "C1539322#ent", "<e1>", "cultures", "had", "returned", "to", "the", "high", "V(v)myo", "phenotype", ",", "C1706544#ent", "<e2>", "expression", "was", "markedly", "lower", "."], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [18, 19]}}
{"token": ["The", "activation", "of", "activator", "protein-1", "nuclear", "factor-kappaB", "induced", "by", "C0078956#ent", "<e1>", "was", "also", "attenuated", "by", "C1417839#ent", "<e2>", "or", "procyanidin", "B2"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417839", "name": "C1417839#ent", "pos": [15, 16]}}
{"token": ["Brevetoxins", "are", "thought", "to", "be", "synthesized", "by", "a", "C0967572#ent", "<e1>", "C3853563#ent", "<e2>", ")", "complex", ",", "but", "the", "gene", "cluster", "this", "C3853563#ent", "<e2>", "has", "yet", "to", "be", "identified", "."], "h": {"id": "C0967572", "name": "C0967572#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3853563", "name": "C3853563#ent", "pos": [10, 11]}}
{"token": ["We", "suggest", "that", "C0069352#ent", "<e1>", "and", "BMY", "42393", "suppress", "monocyte-macrophage", "atherogenic", "activity", "and", "C1333196#ent", "<e2>", "production", "and", "thus", "inhibit", "the", "development", "of", "early", "atherosclerosis", "."], "h": {"id": "C0069352", "name": "C0069352#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "demonstrate", "that", "C0812307#ent", "<e1>", "interacts", "with", "C1416693#ent", "<e2>", "Trip-1", ")", ",", "a", "transcriptional", "regulator", "associated", "with", "T(3", ")", "receptor", ",", "providing", "a", "link", "between", "the", "Epo", "and", "T(3", ")", "signaling", "pathways"], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416693", "name": "C1416693#ent", "pos": [8, 9]}}
{"token": ["C1826650#ent", "<e1>", "is", "a", "novel", "transcription", "factor", "is", "highly", "C1334043#ent", "<e2>", "to", "the", "PAR", "subfamily", "mammalian", "bZIP", "transcription", "factors", "HLF", ",", "DBP", "and", "VBP/TEF", "."], "h": {"id": "C1826650", "name": "C1826650#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["Levels", "of", "ortho-tyrosine", ",", "meta-tyrosine", ",", "and", "o", ",", "o'-dityrosine", ",", "but", "not", "of", "C0047645#ent", "<e1>", ",", "were", "significantly", "higher", "in", "aortic", "tissue", "C1263960#ent", "<e2>", "animals", "."], "h": {"id": "C0047645", "name": "C0047645#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1263960", "name": "C1263960#ent", "pos": [23, 24]}}
{"token": ["The", "predominant", "amino", "acid", "substitution", "both", "in", "the", "adenomas", "and", "in", "the", "differentiated", "tumours", "glycine", "to", "valine", "(", "C1415027#ent", "<e1>", "to", "GTC", ")", "at", "position", "12", "of", "the", "C0079472#ent", "<e2>"], "h": {"id": "C1415027", "name": "C1415027#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0079472", "name": "C0079472#ent", "pos": [28, 29]}}
{"token": ["A", "parallel", "mortality", "survey", "embalmers", "from", "New", "York", "State", "similar", "findings", ",", "with", "C0282193#ent", "<e1>", "of", "brain", "tumors", "leukemia", ",", "colon", "cancer", "arteriosclerotic", "heart", "disease", "and", "C1623038#ent", "<e2>", "."], "h": {"id": "C0282193", "name": "C0282193#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [26, 27]}}
{"token": ["Although", "not", "as", "effective", "as", "Se", ",", "vitamin", "E", "C2712370#ent", "<e1>", "methylmercury", "toxicity", "and", "is", "more", "effective", "than", "Se", "against", "C0947651#ent", "<e2>", "toxicity", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0947651", "name": "C0947651#ent", "pos": [20, 21]}}
{"token": ["We", "found", "that", "deletion", "of", "the", "C3889166#ent", "<e1>", "(", "YCR077c", ")", "gene", "suppresses", "a", "C1334476#ent", "<e2>", "and", "that", "Pat1p", "is", "required", "for", "the", "normal", "initiation", "of", "translation", "."], "h": {"id": "C3889166", "name": "C3889166#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334476", "name": "C1334476#ent", "pos": [14, 15]}}
{"token": ["To", "describe", "the", "morphologic", "characteristics", "of", "C0271051#ent", "<e1>", "the", "use", "of", "optical", "coherence", "tomography", "C0029279#ent", "<e2>", ")", "and", "to", "investigate", "the", "correlation", "between", "tomographic", "features", "and", "visual", "acuity", "VA", ")", "."], "h": {"id": "C0271051", "name": "C0271051#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029279", "name": "C0029279#ent", "pos": [14, 15]}}
{"token": ["These", "results", "provide", "the", "first", "evidence", "that", "endothelium-dependent", "relaxation", "of", "PA", "mediated", "by", "endothelium-derived", "relaxing", "factors", "impaired", "in", "C0013743#ent", "<e1>", "patients", "with", "C0155616#ent", "<e2>"], "h": {"id": "C0013743", "name": "C0013743#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0155616", "name": "C0155616#ent", "pos": [22, 23]}}
{"token": ["We", "studied", "five", "consecutive", "patients", "with", "PH", ";", "one", "with", "primary", "pulmonary", "hypertension", "two", "with", "chronic", "pulmonary", "thromboembolism", "one", "with", "C0013743#ent", "<e1>", "ventricular", "septal", "defect", "and", "one", "with", "C0155616#ent", "<e2>", "a", "ventricular", "septal", "defect", "operation", "."], "h": {"id": "C0013743", "name": "C0013743#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0155616", "name": "C0155616#ent", "pos": [28, 29]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "hyperglycemia", "alone", "attenuates", "collateral", "development", "abolishes", "proliferative", "properties", "of", "myocardial", "interstitial", "fluid", "C3538735#ent", "<e1>", ")", "by", "enhancing", "expression", "of", "C0127082#ent", "<e2>", "MMP", ")", "and", "angiostatin", "."], "h": {"id": "C3538735", "name": "C3538735#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [24, 25]}}
{"token": ["In", "this", "connection", "the", "possibility", "of", "pleural", "effusions", "with", "a", "well", "defined", "cytology", ")", "associated", "or", "with", "typical", "Mycoplasma", "pneumoniae", "of", "C0006285#ent", "<e1>", "evolving", "even", "in", "C0034069#ent", "<e2>", "stressed", "."], "h": {"id": "C0006285", "name": "C0006285#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [26, 27]}}
{"token": ["To", "determine", "whether", "C1412332#ent", "<e1>", "is", "present", "on", "adult", "C0018889#ent", "<e2>", "of", "Wuchereria", "bancrofti", "thin", "sections", "resin-embedded", "parasites", "incubated", "with", "a", "specific", "antiserum", "to", "human", "C1412332#ent", "<e1>", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [9, 10]}}
{"token": ["The", "presence", "of", "EGTA", "or", "C0013618#ent", "<e1>", "caused", "a", "73", "%", "inhibition", "of", "PLA2", "activity", "in", "C0289313#ent", "<e2>", "relative", "to", "the", "activity", "observed", "when", "no", "calcium", "was", "added", "."], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "PI3K", "C1705341#ent", "<e1>", "are", "required", "for", "the", "anti-apoptotic", "effects", "of", "C1705341#ent", "<e1>"], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [3, 4]}}
{"token": ["By", "contrast", ",", "Y402F", "inhibited", "C1705341#ent", "<e1>", "Tyr(402", ")", "phosphorylation", ",", "whereas", "it", "markedly", "enhanced", "AngII-induced", "C1705341#ent", "<e1>", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [5, 6]}}
{"token": ["The", "effects", "of", "new", "C1511576#ent", "<e1>", "roscovitine", "and", "C0289993#ent", "<e2>", ",", "on", "oocytes", "and", "eggs", "of", "Xenopus", "laevis", "investigated", "and", "compared", "with", "those", "of", "6-dimethylamino", "purine", "(", "6-DMAP", ")", "."], "h": {"id": "C1511576", "name": "C1511576#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0289993", "name": "C0289993#ent", "pos": [8, 9]}}
{"token": ["A", "new", "standardized", "surface", "technique", "for", "conduction", "studies", "of", "the", "superficial", "peroneal", "nerve", "developed", "and", "applied", "to", "35", "normal", "subjects", "63", "patients", "with", "peroneal", "mononeuropathies", "lumbar", "radiculopathies", "C0149940#ent", "<e1>", "lumbosacral", "plexopathies", ",", "or", "C0031117#ent", "<e2>"], "h": {"id": "C0149940", "name": "C0149940#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [33, 34]}}
{"token": ["Message", "levels", "GARG-16", ",", "C1415894#ent", "<e1>", ",", "and", "GARG-49/IRG2", "are", "increased", "by", "C0175697#ent", "<e2>", "stimulation", "in", "Swiss", "3T3", "cells", "in", "peritoneal", "macrophages"], "h": {"id": "C1415894", "name": "C1415894#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [12, 13]}}
{"token": ["Tested", "compounds", "not", "alter", "Na+", ",", "K+-ATPase", "and", "C1417500#ent", "<e1>", "+", "-ATPase", "activities", ",", "but", "except", "for", "C0147003#ent", "<e2>", ",", "prevented", "the", "inhibitory", "effect", "of", "homocysteine", "on", "Na+", ",", "K+-ATPase", "activity"], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0147003", "name": "C0147003#ent", "pos": [17, 18]}}
{"token": ["This", "new", "family", "of", "transcarbamylases", "lacks", "the", "DxxSMG", "motif", "that", "is", "characteristic", "of", "all", "C0029279#ent", "<e1>", "OTCases", ")", "and", "contains", "a", "novel", "C3275254#ent", "<e2>", "forms", "part", "of", "the", "active", "site"], "h": {"id": "C0029279", "name": "C0029279#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3275254", "name": "C3275254#ent", "pos": [22, 23]}}
{"token": ["Autopsy", "disclosed", "C0002444#ent", "<e1>", "granulomas", "in", "subcutaneous", "tissue", "the", "left", "adrenal", "gland", "and", "the", "C0771711#ent", "<e2>", ",", "with", "more", "acute", "inflammatory", "lesions", "the", "liver", ",", "kidney", ",", "and", "brain", "."], "h": {"id": "C0002444", "name": "C0002444#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [14, 15]}}
{"token": ["Although", "C1332695#ent", "<e1>", "synthesis", "is", "ongoing", "during", "C3889436#ent", "<e2>", "constant", "C1332695#ent", "<e1>", "levels", "are", "maintained", "."], "h": {"id": "C1332695", "name": "C1332695#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [7, 8]}}
{"token": ["The", "action", "of", "C0019223#ent", "<e1>", "was", "suppressed", "in", "sodium-free", "(", "C0041175#ent", "<e2>", ")", "solution", "or", "in", "the", "presence", "of", "amiloride", "while", "the", "action", "of", "NH4Cl", "was", "always", "observed", "."], "h": {"id": "C0019223", "name": "C0019223#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041175", "name": "C0041175#ent", "pos": [10, 11]}}
{"token": ["Activation", "of", "the", "C0033681#ent", "<e1>", "certain", "DNA-damaging", "agents", "contributes", "to", "downregulation", "of", "C1332733#ent", "<e2>", "and", "G1", "arrest", "a", "p53-dependent", "mechanism", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332733", "name": "C1332733#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", "we", "examined", "the", "effects", "of", "acute", "nutritional", "activation", "of", "C2984537#ent", "<e1>", "on", "expression", "of", "C1417679#ent", "<e2>", "encoding", "intestinal", "barrier", "proteins"], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["Endothelial", "MAdCAM-1", "(", "C1416961#ent", "<e1>", "expression", "is", "associated", "with", "oxidant-dependent", "induction", "and", "progress", "of", "C0021390#ent", "<e2>", "IBD", ")", "."], "h": {"id": "C1416961", "name": "C1416961#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [14, 15]}}
{"token": ["Enhanced", "MAdCAM-1", "(", "C1416961#ent", "<e1>", "expression", "is", "associated", "with", "aetiology", "of", "C0021390#ent", "<e2>", "but", "little", "is", "known", "about", "MAdCAM-1", ":", "regulation", ",", "or", "how", "inflammatory", "bowel", "disease", "therapies", "MAdCAM-1", "."], "h": {"id": "C1416961", "name": "C1416961#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "under", "the", "conditions", "of", "this", "trial", ",", "cyclosporine", "can", "serve", "as", "an", "alternative", "to", "C0030817#ent", "<e1>", "for", "the", "treatment", "of", "patients", "with", "C0003873#ent", "<e2>", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [25, 26]}}
{"token": ["To", "elucidate", "the", "natural", "course", "the", "nephropathy", "associated", "with", "C0030817#ent", "<e1>", "and", "thereby", "facilitate", "its", "clinical", "management", "patients", "with", "C0003873#ent", "<e2>", "developed", "proteinuria", "during", "treatment", "with", "oral", "C0030817#ent", "<e1>", "were", "studied", "in", "detail", "throughout", "their", "renal", "illness"], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["CCR1", "ligands", ",", "including", "CCL3", ",", "CCL5", ",", "and", "C1332692#ent", "<e1>", ",", "are", "up-regulated", "in", "a", "number", "of", "C0027765#ent", "<e2>", "humans", "and", "animal", "models"], "h": {"id": "C1332692", "name": "C1332692#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [18, 19]}}
{"token": ["Unlike", "C0079225#ent", "<e1>", "Mal-HSA", "could", "not", "inhibit", "C0035379#ent", "<e2>", "HIV-1", "."], "h": {"id": "C0079225", "name": "C0079225#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [7, 8]}}
{"token": ["Mucopolysaccharidosis", "type", "I", "MPS-I", ")", "is", "an", "autosomal", "recessive", "C0019247#ent", "<e1>", "by", "a", "deficiency", "of", "the", "C0020818#ent", "<e2>", "is", "required", "for", "the", "lysosomal", "degradation", "the", "glycosaminoglycans", "heparan", "sulfate", "dermatan", "sulfate"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020818", "name": "C0020818#ent", "pos": [16, 17]}}
{"token": ["The", "C1516468#ent", "<e1>", "and", "ischemic", "effects", "of", "a", "fibrin", "clot", "C0026254#ent", "<e2>", "were", "observed", "on", "a", "model", "of", "primary", "hepatoma", "VX-2", "carcinoma", "inoculated", "in", "to", "the", "subcapsule", "of", "the", "liver", "of", "rabbits", "."], "h": {"id": "C1516468", "name": "C1516468#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [10, 11]}}
{"token": ["Since", "patients", "on", "C1516468#ent", "<e1>", "be", "submitted", "to", "nuclear", "medicine", "procedures", "we", "studied", "the", "C0026254#ent", "<e2>", "effect", "on", "the", "bioavailability", "of", "the", "technetium-99m-labelled", "sodium", "pyrophosphate", "(", "9mTc-PYP", ")", "using", "an", "animal", "model"], "h": {"id": "C1516468", "name": "C1516468#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [14, 15]}}
{"token": ["Bacterial", "cells", "the", "chimeric", "gene", "products", "were", "also", "investigated", "as", "to", "their", "sensitivity", "to", "phages", "that", "require", "either", "C0755857#ent", "<e1>", "or", "OmpF", "as", "a", "C1413694#ent", "<e2>"], "h": {"id": "C0755857", "name": "C0755857#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1413694", "name": "C1413694#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "the", "safety", "and", "efficacy", "of", "a", "C0060507#ent", "<e1>", "acetonide", "intravitreal", "implant", "the", "treatment", "of", "C0042167#ent", "<e2>"], "h": {"id": "C0060507", "name": "C0060507#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042167", "name": "C0042167#ent", "pos": [16, 17]}}
{"token": ["This", "review", "explores", "the", "current", "research", "evaluating", "the", "C0060507#ent", "<e1>", "sustained-release", "intravitreal", "implant", "the", "treatment", "of", "C0042167#ent", "<e2>", "the", "implications", "for", "its", "future", "use", "on", "a", "wider", "scale", "."], "h": {"id": "C0060507", "name": "C0060507#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042167", "name": "C0042167#ent", "pos": [16, 17]}}
{"token": ["C1705750#ent", "<e1>", "mobilization", "of", "hematopoietic", "progenitor", "cells", "HPCs", ")", "is", "mediated", "through", "C0014442#ent", "<e2>", "release", "from", "maturing", "myeloid", "cells", "leading", "to", "digestion", "of", "adhesion", "molecules", "trophic", "chemokines", "and", "their", "receptors", ",", "and", "the", "extracellular", "matrix"], "h": {"id": "C1705750", "name": "C1705750#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["A", "comparison", "with", "other", "monoamine", "oxidase", "inhibitors", "C0054085#ent", "<e1>", ",", "moclobemide", "and", "C0036579#ent", "<e2>", ")", "and", "with", "trolox", "was", "made", "."], "h": {"id": "C0054085", "name": "C0054085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036579", "name": "C0036579#ent", "pos": [12, 13]}}
{"token": ["The", "alternatives", "are", "that", "the", "association", "occurred", "purely", "by", "chance", "or", "that", "the", "severe", "C0271801#ent", "<e1>", "state", "led", "to", "C1565489#ent", "<e2>"], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [19, 20]}}
{"token": ["Recently", "it", "was", "shown", "that", "the", "C0751781#ent", "<e1>", "gene", "product", "atrophin-1", ",", "interacts", "with", "the", "human", "insulin", "receptor", "tyrosine", "kinase", "substrate", "protein", "C1332378#ent", "<e2>", "."], "h": {"id": "C0751781", "name": "C0751781#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332378", "name": "C1332378#ent", "pos": [22, 23]}}
{"token": ["The", "expression", "of", "C1332378#ent", "<e1>", "in", "regions", "similar", "to", "those", "that", "degenerate", "in", "C0751781#ent", "<e2>", "supports", "the", "notion", "that", "C1332378#ent", "<e1>", "is", "a", "relevant", "atrophin-1", "binding", "protein", "may", "provide", "a", "mechanism", "for", "region-specific", "neurodegeneration", "."], "h": {"id": "C0751781", "name": "C0751781#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332378", "name": "C1332378#ent", "pos": [3, 4]}}
{"token": ["After", "C1420358#ent", "<e1>", "more", "patients", "experience", "improvement", "of", "C0002962#ent", "<e2>", "than", "deterioration", "(", "15", "versus", "2", "out", "of", "41", ")", ",", "but", "the", "number", "of", "patients", "is", "too", "small", "to", "allow", "solid", "conclusions"], "h": {"id": "C1420358", "name": "C1420358#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [8, 9]}}
{"token": ["Consequently", ",", "vIRF-3", "stimulates", "the", "IRF-3-", "and", "IRF-7-mediated", "activation", "of", "type", "I", "interferon", "C1708406#ent", "<e1>", "and", "IFNB", ")", "C0017337#ent", "<e2>", "and", "the", "synthesis", "of", "biologically", "active", "I", "interferons", "in", "infected", "B", "cells"], "h": {"id": "C1708406", "name": "C1708406#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["C0147080#ent", "<e1>", "a", "family", "of", "C2717971#ent", "<e2>", "are", "implicated", "in", "the", "proliferation", "of", "smooth", "muscle", "cells", "fibroblasts", ",", "upregulation", "of", "interleukin-8", "synthesis", "endothelial", "cells", "and", "recruitment", "of", "neutrophils", "and", "eosinophils", "."], "h": {"id": "C0147080", "name": "C0147080#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [5, 6]}}
{"token": ["The", "genus", "Bartonella", "comprises", "human-specific", "and", "C0043528#ent", "<e1>", "pathogens", "responsible", "for", "a", "wide", "range", "of", "clinical", "manifestations", "including", "C0029307#ent", "<e2>", "trench", "fever", "cat", "scratch", "disease", "bacillary", "angiomatosis", "peliosis", ",", "endocarditis", "and", "bacteremia", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0029307", "name": "C0029307#ent", "pos": [18, 19]}}
{"token": ["Evidence", "indicates", "that", "patients", "with", "familial", "achalasia", "associated", "with", "Allgrove", "or", "triple-A", "syndrome", "i.e.", "alacrima", ",", "C1321756#ent", "<e1>", "and", "adrenocorticotropin-resistant", "adrenal", "insufficiency", "neurological", "impairment", "have", "mutations", "of", "the", "C0271742#ent", "<e2>", "adrenal", "insufficiency", "syndrome", "AAAS", ")", "gene", "."], "h": {"id": "C1321756", "name": "C1321756#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C0271742", "name": "C0271742#ent", "pos": [28, 29]}}
{"token": ["Plasma", "concentrations", "of", "C3273854#ent", "<e1>", "increased", "significantly", "following", "elective", "operative", "repair", "thoraco-abdominal", "and", "C0162871#ent", "<e2>", "and", "after", "bowel", "resection", "inflammatory", "bowel", "disease", "but", "did", "not", "increase", "after", "laparoscopic", "cholecystectomy"], "h": {"id": "C3273854", "name": "C3273854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162871", "name": "C0162871#ent", "pos": [13, 14]}}
{"token": ["A", "role", "for", "C0002085#ent", "<e1>", "variation", "within", "the", "gene", "for", "the", "antioxidant", "selenoprotein", "glutathione", "peroxidase", "1", "C0763282#ent", "<e2>", ")", "in", "the", "risk", "or", "etiology", "of", "breast", "cancer", "investigated", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0763282", "name": "C0763282#ent", "pos": [16, 17]}}
{"token": ["Irradiation", "of", "skin", "with", "ultraviolet", "B", "UVB", ")", "stimulates", "epidermal", "activity", "ornithine", "decarboxylase", "C1422630#ent", "<e1>", ")", ",", "a", "rate", "limiting", "polyamine", "biosynthesing", "C0014442#ent", "<e2>", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [22, 23]}}
{"token": ["The", "flow", "of", "information", "from", "calcium-mobilizing", "receptors", "nuclear", "factor", "activated", "T", "cells", "C0017337#ent", "<e1>", "is", "critically", "dependent", "on", "interaction", "between", "the", "C0908197#ent", "<e2>", "the", "transcription", "factor", "NFAT"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0908197", "name": "C0908197#ent", "pos": [21, 22]}}
{"token": ["Their", "metabolic", "status", "oral", "glucose", "tolerance", "test", "euglycemic", ",", "C0020459#ent", "<e1>", ")", ",", "serum", "lipid", "profile", ",", "muscle", "fiber", "distribution", "(", "C0027096#ent", "<e2>", ",", "and", "capillary", "supply", "amylase-periodic", "acid-Schiff", "method", ")", "was", "evaluated", "."], "h": {"id": "C0020459", "name": "C0020459#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [21, 22]}}
{"token": ["The", "results", "of", "molecular", "cloning", "homology", "searches", "identified", "a", "minimum", "of", "five", "different", "C0086376#ent", "<e1>", "of", "the", "C1414254#ent", "<e2>", "edg", ")", "encoded", "subfamily", "of", "GPCRs", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414254", "name": "C1414254#ent", "pos": [17, 18]}}
{"token": ["Diuretic", "and", "C0597421#ent", "<e1>", "atrial", "extracts", "from", "BIO", "14.6", "(", "C0033141#ent", "<e2>", ")", "and", "F1B", "(", "normal", ")", "hamsters", "at", "180", "days", "of", "age", "were", "measured", "by", "rat", "bioassay", "."], "h": {"id": "C0597421", "name": "C0597421#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033141", "name": "C0033141#ent", "pos": [10, 11]}}
{"token": ["One", "IDH", ",", "six", "ACP", ",", "six", "C1861457#ent", "<e1>", ",", "and", "six", "EST", "C0022173#ent", "<e2>", "were", "induced", "in", "cultured", "callus", "tissues", "medium", "containing", "three", "2,4-dichlorophenoxyacetic", "acid", "kinetin", "combinations", "."], "h": {"id": "C1861457", "name": "C1861457#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [13, 14]}}
{"token": ["Neither", "GRP-R", "C1416746#ent", "<e1>", "nor", "WT", "mice", "suppressed", "glucose", "intake", "C1417740#ent", "<e2>", "administration", "."], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417740", "name": "C1417740#ent", "pos": [10, 11]}}
{"token": ["Two", "binding", "sites", "T", "antigen", "apparent", "on", "the", "C1458146#ent", "<e1>", "one", "consisting", "of", "C3539946#ent", "<e2>", "139", ",", "the", "other", "present", "in", "the", "383", "-", "765", "region", "of", "the", "protein", "."], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [13, 14]}}
{"token": ["A", "quantitative", "approach", "attempted", ",", "using", "an", "LFE", "model", ",", "correlating", "the", "effect", "of", "structural", "modification", "C0917721#ent", "<e1>", "inhibition", "activity", "the", "prepared", "C0012512#ent", "<e2>", "."], "h": {"id": "C0917721", "name": "C0917721#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012512", "name": "C0012512#ent", "pos": [22, 23]}}
{"token": ["A", "double-blind", "multicentre", "study", "conducted", "to", "compare", "the", "efficacy", "and", "safety", "of", "tenoxicam", "and", "C0022635#ent", "<e1>", "in", "the", "treatment", "of", "C0029408#ent", "<e2>", "(", "OA", ")", "."], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "when", "the", "non-drug", "reinforcer", "was", "discontinued", ",", "alcohol", "seeking", "recurred", "even", "though", "C0001962#ent", "<e1>", "was", "still", "unavailable", "for", "lever", "C3640016#ent", "<e2>", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3640016", "name": "C3640016#ent", "pos": [21, 22]}}
{"token": ["To", "study", "incidence", "and", "causes", "of", "C0205721#ent", "<e1>", "NRI", ")", "and", "its", "influence", "on", "clinical", "manifestations", "C0004096#ent", "<e2>", "BA", ")", "."], "h": {"id": "C0205721", "name": "C0205721#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["Recombinant", "vaccinia", "viruses", "expressing", "either", "the", "premembrane/truncated", "envelope", "(", "PrM/TrE", ")", "or", "truncated", "envelope", "C1421113#ent", "<e1>", ")", "protein", "of", "C0024025#ent", "<e2>", "constructed", "."], "h": {"id": "C1421113", "name": "C1421113#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024025", "name": "C0024025#ent", "pos": [19, 20]}}
{"token": ["The", "early", "foci", "induced", "by", "C0042769#ent", "<e1>", "significantly", "exacerbated", "following", "a", "single", "inoculation", "with", "C0339959#ent", "<e2>"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0339959", "name": "C0339959#ent", "pos": [14, 15]}}
{"token": ["This", "enzyme", "displayed", "the", "structural", "characteristics", "of", "a", "C0162745#ent", "<e1>", "and", "was", "named", "C1567335#ent", "<e2>", ",", "or", "MMP-13", "according", "to", "MMP", "nomenclature", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1567335", "name": "C1567335#ent", "pos": [13, 14]}}
{"token": ["Correction", "of", "C0005745#ent", "<e1>", "in", "patients", "with", "C0022541#ent", "<e2>", "problematic", "because", "the", "C0005745#ent", "<e1>", "enlarges", "the", "palpebral", "fissure", "aggravates", "the", "lagophthalmos", "."], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0022541", "name": "C0022541#ent", "pos": [7, 8]}}
{"token": ["Although", "the", "C0248441#ent", "<e1>", "Rsk", ")", "was", "also", "dephosphorylated", ",", "C3849574#ent", "<e2>", "phosphorylation", "was", "not", "affected", "in", "the", "enzastaurin-treated", "gastric", "cancer", "cells", "."], "h": {"id": "C0248441", "name": "C0248441#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [10, 11]}}
{"token": ["Therefore", ",", "inhibition", "of", "C0242980#ent", "<e1>", "not", "evoke", "established", "C0013384#ent", "<e2>", "in", "MPTP-treated", "primates", "."], "h": {"id": "C0242980", "name": "C0242980#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [9, 10]}}
{"token": ["In", "MPTP", "(", "1-methyl", "4-phenyl-tetrahydropyridine", "1,2,3,6)-lesioned", "marmosets", ",", "C0242980#ent", "<e1>", "been", "demonstrated", "to", "reverse", "parkinsonian", "signs", "without", "evoking", "established", "C0013384#ent", "<e2>", "."], "h": {"id": "C0242980", "name": "C0242980#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "when", "thyrosine", ",", "lysine", "and", "N-terminal", "amino", "acids", "modified", ",", "C0599220#ent", "<e1>", "of", "LDH-5", "and", "C1412344#ent", "<e2>", "their", "capacity", "to", "restore", "their", "quaternary", "structures"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412344", "name": "C1412344#ent", "pos": [17, 18]}}
{"token": ["High", "frequency", "to", "the", "rugose", "phenotype", "is", "more", "common", "in", "epidemic", "strains", "than", "in", "non-pathogenic", "strains", ",", "suggesting", "C1868684#ent", "<e1>", "production", "and", "the", "rugose", "phenotype", "important", "in", "C0008354#ent", "<e2>", "epidemiology", "."], "h": {"id": "C1868684", "name": "C1868684#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008354", "name": "C0008354#ent", "pos": [27, 28]}}
{"token": ["However", ",", "C0074722#ent", "<e1>", "NaHCO3", ")", "used", "to", "C0546869#ent", "<e2>", "L-HCl", ")", "to", "lidocaine", "base", "induces", "a", "pH", "increase", "that", "could", "be", "irritating", "for", "mucosa", "in", "the", "case", "of", "cuff", "rupture"], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0546869", "name": "C0546869#ent", "pos": [8, 9]}}
{"token": ["C0086795#ent", "<e1>", "HS", ")", ",", "the", "most", "severe", "form", "of", "C0026705#ent", "<e2>", "causes", "progressive", "deterioration", "of", "the", "central", "nervous", "system", "death", "in", "childhood", "."], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0026705", "name": "C0026705#ent", "pos": [10, 11]}}
{"token": ["When", "the", "inhibitory", "effect", "of", "C0030038#ent", "<e1>", "on", "transmitter", "release", "studied", ",", "C0030311#ent", "<e2>", ",", "pirenzepine", "and", "atropine", "were", "competitive", "antagonists", "of", "presynaptic", "muscarinic", "receptors", "on", "the", "noradrenergic", "axon", "terminals", "the", "atrium", "."], "h": {"id": "C0030038", "name": "C0030038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030311", "name": "C0030311#ent", "pos": [12, 13]}}
{"token": ["Here", ",", "we", "investigated", "the", "effect", "of", "eicosapentaenoic", "acid", "C1705819#ent", "<e1>", ")", ",", "a", "dietary", "omega-3", "fatty", "acid", "on", "UV-induced", "C0166027#ent", "<e2>", "expression", "in", "human", "dermal", "fibroblasts", "HDFs", ")", "."], "h": {"id": "C1705819", "name": "C1705819#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "our", "results", "demonstrate", "that", "C1705819#ent", "<e1>", "can", "inhibit", "UV-induced", "C0166027#ent", "<e2>", "expression", "by", "inhibiting", "the", "MEK1/ERK/c-Fos", "and", "SEK1/JNK/c-Jun", "pathways", "."], "h": {"id": "C1705819", "name": "C1705819#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [12, 13]}}
{"token": ["We", "also", "found", "that", "C1705819#ent", "<e1>", "inhibited", "12-O-tetradecanoylphorbol-13-acetate-", "or", "tumor", "necrosis", "C0166027#ent", "<e2>", "expression", "in", "HDFs", "and", "UV-induced", "C0166027#ent", "<e2>", "expression", "in", "HaCaT", "cells", "."], "h": {"id": "C1705819", "name": "C1705819#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [11, 12]}}
{"token": ["In", "order", "to", "assess", "the", "genetic", "basis", "this", "syndrome", "we", "investigated", "two", "candidate", "genes", ":", "C1121761#ent", "<e1>", "and", "ATP2A3", "encoding", "the", "manganese-transporting", "calcium-ATPases", ",", "C1825505#ent", "<e2>", "and", "SERCA3", ",", "respectively", "."], "h": {"id": "C1121761", "name": "C1121761#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1825505", "name": "C1825505#ent", "pos": [24, 25]}}
{"token": ["AP-1", "promoter", "activity", "p38", "MAPK", "activation", "but", "not", "C1826724#ent", "<e1>", ",", "ERK", "and", "JNK", "activation", "induced", "by", "C2697656#ent", "<e2>", "were", "attenuated", "by", "oregonin", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "role", "of", "nitric", "oxide", "C1826724#ent", "<e1>", "in", "lipopolysaccharide", "(", "C2697656#ent", "<e2>", ")", "mediated", "vascular", "hyporeactivity", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [15, 16]}}
{"token": ["Protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "activation", "by", "phorbol-ester", "prior", "to", "C2697656#ent", "<e2>", "resulted", "in", "a", "fivefold", "greater", "IL-10", "production", "in", "G6PD-deficient", "macrophages", "compared", "with", "WT", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [11, 12]}}
{"token": ["C1332823#ent", "<e1>", "expression", "on", "peripheral", "T", "cells", "significantly", "higher", "in", "patients", "with", "C0009324#ent", "<e2>", "UC", ")", "compared", "with", "normal", "controls", "and", "C1332823#ent", "<e1>", "expression", "levels", "of", "UC", "patients", "correlated", "with", "disease", "activity"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [0, 1]}}
{"token": ["C0040905#ent", "<e1>", "proved", "valuable", "as", "phosphate", "protecting", "group", "especially", "in", "C0085536#ent", "<e2>", "to", "its", "stability", "in", "acidic", "conditions", "."], "h": {"id": "C0040905", "name": "C0040905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [10, 11]}}
{"token": ["C1522575#ent", "<e1>", "also", "suppressed", "C1413553#ent", "<e2>", "mRNA", "expression", "in", "endothelial", "cells", "hours", "after", "administration", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413553", "name": "C1413553#ent", "pos": [4, 5]}}
{"token": ["Both", "IMB-", "and", "C1413366#ent", "<e1>", "stimulation-induced", "hypocalcemia", "was", "antagonized", "by", "C0003385#ent", "<e2>", "histamine", "H2", "blocker"], "h": {"id": "C1413366", "name": "C1413366#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003385", "name": "C0003385#ent", "pos": [10, 11]}}
{"token": ["We", "hypothesized", "that", "administration", "of", "C0304604#ent", "<e1>", "4", "weeks", "to", "C0037384#ent", "<e2>", "children", "with", "only", "mild", "elevation", "their", "apnea-hypopnea", "index", "would", "improve", "both", "polysomnography", "findings", "and", "symptoms", "of", "sleep-disordered", "breathing"], "h": {"id": "C0304604", "name": "C0304604#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037384", "name": "C0037384#ent", "pos": [10, 11]}}
{"token": ["C0304604#ent", "<e1>", "improved", "symptoms", "and", "polysomnography", "findings", "in", "children", "with", "C0037384#ent", "<e2>", "."], "h": {"id": "C0304604", "name": "C0304604#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037384", "name": "C0037384#ent", "pos": [10, 11]}}
{"token": ["Deletion", "of", "C2347054#ent", "<e1>", "deregulated", "TMP1", "and", "C1335630#ent", "<e2>", "but", "did", "not", "interfere", "with", "premeiotic", "S-phase", "meiotic", "recombination", "or", "spore", "formation", "."], "h": {"id": "C2347054", "name": "C2347054#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335630", "name": "C1335630#ent", "pos": [7, 8]}}
{"token": ["During", "neuritogenesis", "of", "primary", "neocortical", "neurons", ",", "both", "C1704843#ent", "<e1>", "isoforms", "as", "well", "as", "C1334879#ent", "<e2>", "were", "located", "in", "axonal", "and", "dendritic", "processes"], "h": {"id": "C1704843", "name": "C1704843#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334879", "name": "C1334879#ent", "pos": [14, 15]}}
{"token": ["The", "WRN", "gene", "defective", "in", "C1421487#ent", "<e1>", "belongs", "to", "the", "RecQ", "family", "C0114667#ent", "<e2>", "Yu", "et", "al.", ",", "1996", ")", "."], "h": {"id": "C1421487", "name": "C1421487#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0114667", "name": "C0114667#ent", "pos": [12, 13]}}
{"token": ["15", "s.", "The", "binding", "of", "[3H]ryanodine", "is", "Ca(2+)-independent", ":", "it", "is", "slightly", "stimulated", "by", "NaCl", ",", "Mg2+", "C2744579#ent", "<e1>", "and", "InsP3", "but", "strongly", "inhibited", "by", "caffeine", ",", "C0012373#ent", "<e2>", "and", "sodium", "dantrolene"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0012373", "name": "C0012373#ent", "pos": [27, 28]}}
{"token": ["Examination", "of", "endoplasmic", "reticulum", "marker", "C3540017#ent", "<e1>", "showed", "depression", "of", "cytochromes", "P-450", "C1864824#ent", "<e2>", "from", "9", "h", "onward", "after", "poly(IC", ")", "administration", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1864824", "name": "C1864824#ent", "pos": [12, 13]}}
{"token": ["Sequential", "measurements", "of", "dung", "pat", "circumferences", "from", "20", "June", "1989", "to", "7", "March", "1990", "showed", "highly", "significant", "differences", "between", "C0022322#ent", "<e1>", "and", "control", "pats", "between", "C0022322#ent", "<e1>", "and", "C0069763#ent", "<e1>", "pats", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0069763", "name": "C0069763#ent", "pos": [28, 29]}}
{"token": ["C4284736#ent", "<e1>", ",", "a", "fragment", "of", "hepatocyte", "growth", "factor", "acts", "as", "its", "C1516869#ent", "<e2>"], "h": {"id": "C4284736", "name": "C4284736#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [12, 13]}}
{"token": ["However", ",", "some", "drugs", "currently", "on", "the", "market", ",", "including", "C0529793#ent", "<e1>", "and", "the", "selective", "C0162758#ent", "<e2>", "appear", "to", "have", "efficacy", "in", "the", "treatment", "of", "PE", "."], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [15, 16]}}
{"token": ["The", "first", "biochemical", "studies", "of", "RGS", "proteins", "shown", "that", "they", "accelerate", "the", "C1333729#ent", "<e1>", "activities", "of", "C0887847#ent", "<e2>", "thus", "driving", "G", "proteins", "their", "inactive", "GDP-bound", "forms", "."], "h": {"id": "C1333729", "name": "C1333729#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0887847", "name": "C0887847#ent", "pos": [16, 17]}}
{"token": ["Minimal", "effects", "were", "noted", "during", "terminal", "differentiation", "with", "both", "C3537453#ent", "<e1>", "although", "all", "concentrations", "of", "C0011816#ent", "<e2>", "lowered", "apoptotic", "cell", "number"], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [15, 16]}}
{"token": ["Activity", "by", "oral", "treatment", "miconazole", ",", "ketoconazole", "and", "itraconazole", "was", "compared", "in", "gastro-intestinal", "candidosis", "the", "guinea-pig", ",", "in", "C0700345#ent", "<e1>", "the", "rat", "and", "in", "C0006840#ent", "<e2>", "the", "guinea-pig", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [24, 25]}}
{"token": ["Two", "noteworthy", "exceptions", "are", "the", "C0010068#ent", "<e1>", "which", "has", "reduced", "log", "phase", "expression", "and", "serum", "induction", "in", "C0079068#ent", "<e2>", "null", "cells", "and", "the", "growth", "arrest", "gene", "gadd45", ",", "which", "is", "derepressed", "by", "C0079068#ent", "<e2>", "knockout", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [17, 18]}}
{"token": ["Intranasal", "CS", "treatment", "significantly", "increased", "C1538586#ent", "<e1>", "neutrophils", ",", "lymphocytes", ",", "C0022575#ent", "<e2>", ",", "TNF-alpha", ",", "and", "mucin", "."], "h": {"id": "C1538586", "name": "C1538586#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022575", "name": "C0022575#ent", "pos": [11, 12]}}
{"token": ["Infective", "endocarditis", "complicate", "MAC", "or", "C0003507#ent", "<e1>", "patients", "with", "C0035078#ent", "<e2>", "and", "is", "associated", "with", "high", "mortality", "rate", "in", "such", "patients", "."], "h": {"id": "C0003507", "name": "C0003507#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [9, 10]}}
{"token": ["The", "genes", "for", "the", "enzymes", "methylenetetrahydrofolate", "reductase", "MTHFR", ")", ",", "methionine", "synthase", "MS", ")", ",", "C0672719#ent", "<e1>", "MSR", ")", "and", "C1439329#ent", "<e2>", "(", "CBS", ")", "play", "an", "important", "role", "in", "homocysteine", "metabolism"], "h": {"id": "C0672719", "name": "C0672719#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1439329", "name": "C1439329#ent", "pos": [20, 21]}}
{"token": ["These", "data", "indicate", "that", "C1426047#ent", "<e1>", "functions", "as", "a", "C1424988#ent", "<e2>", "links", "PKA", "to", "components", "of", "the", "exocytosis", "machinery", "."], "h": {"id": "C1426047", "name": "C1426047#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424988", "name": "C1424988#ent", "pos": [9, 10]}}
{"token": ["This", "C0039082#ent", "<e1>", "is", "characterized", "by", "vasculopathy", ",", "hypercoagulable", "state", "ischemic", "cerebral", "events", "C0085642#ent", "<e2>", "heart", "valve", "disease", "and", "renal", "insufficiency"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085642", "name": "C0085642#ent", "pos": [13, 14]}}
{"token": ["Since", "aquaporin", "expression", "is", "modulated", "by", "microtubule-dependent", "trafficking", "between", "endoplasmic", "reticulum", "cell", "membranes", "we", "used", "the", "microtubule", "poison", "C0009262#ent", "<e1>", "to", "assess", "the", "importance", "of", "aquaporins", "in", "mediating", "C3890216#ent", "<e2>", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3890216", "name": "C3890216#ent", "pos": [28, 29]}}
{"token": ["The", "maintenance", "of", "C4282429#ent", "<e1>", "ES", ")", "cells", "is", "dependent", "on", "the", "cytokine", "C1366463#ent", "<e2>", "."], "h": {"id": "C4282429", "name": "C4282429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366463", "name": "C1366463#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", "interactions", "between", "optic", "nerve", "its", "target", ",", "the", "optic", "tectum", "necessary", "for", "maintaining", "C1704949#ent", "<e1>", "D-type", "glutamate", "receptor", "gene", "in", "both", "retinal", "and", "C1420683#ent", "<e2>", "neurons", "."], "h": {"id": "C1704949", "name": "C1704949#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420683", "name": "C1420683#ent", "pos": [27, 28]}}
{"token": ["Repeated", "administration", "of", "PKC", "inhibitors", "chelerythrine", "and", "1-(5-isoquinolinesulfonyl)-2-methylpiperazine", "dihydrochloride", "C0525773#ent", "<e1>", "did", "not", "alter", "the", "tolerance", "to", "C0525773#ent", "<e1>", ";", "however", ",", "dependence", "(", "defined", "as", "naloxone-induced", "withdrawal", "C0020429#ent", "<e1>", ")", "was", "blocked", "."], "h": {"id": "C0525773", "name": "C0525773#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [28, 29]}}
{"token": ["Antisense", "but", "not", "mismatch", "ODN", "treatment", "significantly", "decreased", "peripheral", "(", "D-Ala2", ",", "N-Me-Phe4", ",", "Gly5-ol)-enkephalin", "(", "C0525773#ent", "<e1>", ")", "inhibition", "of", "prostaglandin", "E2", "PGE2", ")", "C0020429#ent", "<e2>", "."], "h": {"id": "C0525773", "name": "C0525773#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [25, 26]}}
{"token": ["Intensified", "C0085826#ent", "<e1>", "not", "reduce", "ECG", "signs", "either", "C4025182#ent", "<e2>", "or", "ambulatory", "myocardial", "ischemia"], "h": {"id": "C0085826", "name": "C0085826#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4025182", "name": "C4025182#ent", "pos": [8, 9]}}
{"token": ["Loop", "diuretics", "with", "or", "without", "C0025854#ent", "<e1>", "or", "a", "thiazide", "diuretic", "are", "quite", "useful", "in", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0025854", "name": "C0025854#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [17, 18]}}
{"token": ["FK506", ",", "a", "specific", "calcineurin", "inhibitor", ",", "inhibited", "the", "enhancing", "effect", "of", "adenosine", "on", "the", "NGF-induced", "neurite", "outgrowth", "and", "increased", "the", "C2926735#ent", "<e1>", "of", "p38", "MAP", "kinase", "phosphorylation", "without", "affecting", "C1370600#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [30, 31]}}
{"token": ["Thus", ",", "angiotensin", "II", "by", "a", "mechanism", "that", "requires", "the", "participation", "of", "p38", "MAPK", "differentially", "regulates", "expression", "of", "NF-kappaB-dependent", "genes", "response", "to", "interleukin-1beta", "stimulation", "by", "controlling", "the", "C2926735#ent", "<e1>", "of", "activation", "of", "C1370600#ent", "<e2>", "and", "NF-kappaB."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [32, 33]}}
{"token": ["Recent", "progress", "has", "demonstrated", "that", "differences", "in", "the", "C2926735#ent", "<e1>", ",", "magnitude", "and", "subcellular", "compartmentalization", "of", "C1370600#ent", "<e2>", "activity", "generate", "variations", "in", "signaling", "output", "that", "regulate", "cell", "fate", "decisions", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [16, 17]}}
{"token": ["C2985443#ent", "<e1>", "and", "triple", "TCF/LEF", "binding", "sites", "were", "conserved", "between", "human", "C1414060#ent", "<e2>", "promoter", "and", "rodent", "Dkk4", "promoter", "."], "h": {"id": "C2985443", "name": "C2985443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414060", "name": "C1414060#ent", "pos": [11, 12]}}
{"token": ["The", "HeLa", "cDNA", "sequence", "is", "highly", "similar", "to", "C1417054#ent", "<e1>", "and", "it", "encodes", "peptides", "obtained", "directly", "from", "human", "erythrocyte", "C4049859#ent", "<e2>", "."], "h": {"id": "C1417054", "name": "C1417054#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [19, 20]}}
{"token": ["We", "recently", "identified", "an", "Arabidopsis", "protein", "C1417054#ent", "<e1>", ",", "that", "is", "homologous", "to", "subunit", "5a", "C4049859#ent", "<e2>", ")", "of", "the", "human", "26", "S", "protease", "complex"], "h": {"id": "C1417054", "name": "C1417054#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [15, 16]}}
{"token": ["Based", "upon", "the", "C1417054#ent", "<e1>", "cDNA", "sequence", "have", "now", "isolated", "a", "HeLa", "cell", "coding", "for", "human", "C4049859#ent", "<e2>", "."], "h": {"id": "C1417054", "name": "C1417054#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [16, 17]}}
{"token": ["The", "induction", "of", "sustained", "VT", "or", "C0042510#ent", "<e1>", "increased", "to", "50", "%", "after", "C0025887#ent", "<e2>", "and", "to", "80", "%", "following", "propafenone", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0025887", "name": "C0025887#ent", "pos": [13, 14]}}
{"token": ["Previously", ",", "we", "found", "that", "C0162508#ent", "<e1>", "represses", "the", "tumor", "suppressor", "p21((Waf1/Cip1/Sdi1", ")", ")", "(", "C3470429#ent", "<e2>", ")", "gene", "expression"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [15, 16]}}
{"token": ["Chromatin", "immunoprecipitation", "preferential", "association", "of", "C0162508#ent", "<e1>", "with", "the", "C3470429#ent", "<e2>", "(", "cyclin-dependent", "kinase", "inhibitor", "gene", "promoter", "vinblastine", "treatment", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [9, 10]}}
{"token": ["during", "30", "min", ")", ",", "the", "C0051989#ent", "<e1>", "not", "influence", "the", "pressure", "action", "C2698414#ent", "<e2>", "."], "h": {"id": "C0051989", "name": "C0051989#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [13, 14]}}
{"token": ["Increasing", "understanding", "of", "the", "pathogenesis", "of", "C0010927#ent", "<e1>", "has", "suggested", "several", "novel", "therapies", "designed", "to", "correct", "C2713546#ent", "<e2>", "in", "inhibitors", "of", "coagulation", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [16, 17]}}
{"token": ["We", "present", "one", "patient", "who", "experienced", "erythema", "multiforme", "urticaria", "after", "administration", "of", "C0034239#ent", "<e1>", "for", "treatment", "of", "C0041296#ent", "<e2>"], "h": {"id": "C0034239", "name": "C0034239#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [17, 18]}}
{"token": ["C0238339#ent", "<e1>", "developed", "in", "patients", "with", "C0001622#ent", "<e2>", "no", "influence", "on", "blood", "serum", "RIT", "content", "."], "h": {"id": "C0238339", "name": "C0238339#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [6, 7]}}
{"token": ["Fourth", ",", "we", "used", "the", "H-box", "to", "search", "the", "B.", "quintana", "genome", "and", "discovered", "a", "number", "of", "intriguing", "C0079941#ent", "<e1>", "e.g.", ",", "five", "members", "of", "a", "six-member", "family", "of", "C4046042#ent", "<e2>"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4046042", "name": "C4046042#ent", "pos": [29, 30]}}
{"token": ["The", "deduced", "amino", "acid", "of", "the", "other", "identified", "C0079941#ent", "<e1>", "were", "homologous", "to", "known", "C4046042#ent", "<e2>", "and", "found", "to", "contain", "an", "N-terminal", "signal", "sequence", "a", "C-terminal", "domain", "could", "constitute", "a", "beta-barrel", "in", "the", "outer", "membrane"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4046042", "name": "C4046042#ent", "pos": [14, 15]}}
{"token": ["The", "genome", "sequences", "Neisseria", "meningitidis", "serogroup", "B", "strain", "MC58", "serogroup", "A", "Z2491", "were", "systematically", "searched", "for", "C0079941#ent", "<e1>", "ORFs", ")", "encoding", "C4046042#ent", "<e2>", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4046042", "name": "C4046042#ent", "pos": [21, 22]}}
{"token": ["There", "are", "only", "two", "case", "reports", "to", "the", "use", "of", "C0015020#ent", "<e1>", "during", "radiotherapy", ",", "one", "case", "with", "C0036391#ent", "<e2>", "and", "the", "other", "with", "SJS-TEN", "overlap", "."], "h": {"id": "C0015020", "name": "C0015020#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036391", "name": "C0036391#ent", "pos": [18, 19]}}
{"token": ["Human", "brain", "endothelial", "cells", "HBECs", ")", "are", "resistant", "to", "Escherichia", "coli-derived", "Shiga", "toxin", "C1539874#ent", "<e1>", ")", ";", "however", ",", "inflammatory", "cytokines", "increase", "C2827566#ent", "<e2>", "sensitivity", "to", "C1539874#ent", "<e1>", "cytotoxicity", "."], "h": {"id": "C2827566", "name": "C2827566#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1539874", "name": "C1539874#ent", "pos": [13, 14]}}
{"token": ["Biochemical", "markers", "bone", "metabolism", "bone-specific", "alkaline", "phosphatase", "osteocalcin", ",", "deoxypyridinoline", ")", "and", "C1706113#ent", "<e1>", "genotype", ",", "using", "C0059137#ent", "<e2>", "were", "determined", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0059137", "name": "C0059137#ent", "pos": [17, 18]}}
{"token": ["The", "mechanism", "of", "interaction", "of", "the", "C0003211#ent", "<e1>", "etoricoxib", "and", "parecoxib", "sodium", "with", "human", "serum", "albumin", "C0393754#ent", "<e2>", ")", "was", "studied", "using", "fluorescence", "spectroscopy"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [16, 17]}}
{"token": ["The", "interaction", "of", "a", "C0003211#ent", "<e1>", "niflumic", "acid", "NFA", ")", ",", "with", "human", "serum", "albumin", "C0393754#ent", "<e2>", ")", "has", "been", "investigated", "by", "(19)F", "nuclear", "magnetic", "resonance", "NMR", ")", "spectroscopy", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [15, 16]}}
{"token": ["The", "abnormalities", "in", "iron", "metabolism", "associated", "with", "C0002888#ent", "<e1>", "rapidly", "reversed", "by", "B(12", ")", "therapy", "in", "C0002892#ent", "<e2>", "PA", ")", "."], "h": {"id": "C0002888", "name": "C0002888#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0002892", "name": "C0002892#ent", "pos": [16, 17]}}
{"token": ["The", "predicted", "DapC", "protein", "C.", "glutamicum", "shared", "29", "%", "identical", "C3539947#ent", "<e1>", "DapC", "from", "Bordetella", "pertussis", "the", "only", "enzymatically", "characterized", "C0762034#ent", "<e2>"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0762034", "name": "C0762034#ent", "pos": [20, 21]}}
{"token": ["Par6B", "localizes", "to", "the", "cytosol", "and", "inhibits", "TJ", "formation", ",", "but", "C1705807#ent", "<e1>", "co-localizes", "predominantly", "with", "the", "TJ", "marker", "C1420744#ent", "<e2>", "at", "cell-cell", "contacts", "does", "not", "affect", "junctions", "."], "h": {"id": "C1705807", "name": "C1705807#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420744", "name": "C1420744#ent", "pos": [19, 20]}}
{"token": ["DaPKC", "interacts", "with", "partitioning-defective", "3", "Par-3", ")", "and", "C1705807#ent", "<e1>", "which", "contain", "PDZ", "(", "PSD95", ",", "DLG", ",", "C1420744#ent", "<e2>", ")", "domains", "."], "h": {"id": "C1705807", "name": "C1705807#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420744", "name": "C1420744#ent", "pos": [18, 19]}}
{"token": ["Albumin-binding", "levels", "in", "C1875400#ent", "<e1>", "from", "C1705280#ent", "<e2>", ",", "APSGN", "and", "tonsillitis", "were", "significantly", "higher", "than", "in", "C1875400#ent", "<e1>", "from", "healthy", "carriers", "P", "<", "0.001", ")", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [3, 4]}}
{"token": ["Peak", "periods", "C1705280#ent", "<e1>", "were", "associated", "with", "GAS", "C1875400#ent", "<e2>", "possessing", "an", "emm18", "allele", "encoding", "the", "protein", "found", "in", "serotype", "M18", "C1875400#ent", "<e2>", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [8, 9]}}
{"token": ["We", "have", "previously", "identified", "an", "C1704672#ent", "<e1>", "efp", "(", "estrogen-responsive", "finger", "protein", ",", "that", "encodes", "a", "putative", "C1421688#ent", "<e2>", "Proc", "."], "h": {"id": "C1704672", "name": "C1704672#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421688", "name": "C1421688#ent", "pos": [17, 18]}}
{"token": ["Human", "pp60c-Src", "(", "or", "c-Src", ")", "is", "a", "60", "kDa", "nonreceptor", "tyrosine", "kinase", "encoded", "by", "the", "C0038085#ent", "<e1>", "is", "the", "cellular", "homologue", "the", "potent", "transforming", "C3853557#ent", "<e2>"], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3853557", "name": "C3853557#ent", "pos": [25, 26]}}
{"token": ["Specific", "pulmonary", "diseases", "discussed", "including", ":", "C0004626#ent", "<e1>", "bronchitis", ",", "mycobacterial", "and", "fungal", "infections", "pneumocystis", "carinii", "pneumonia", "C0040558#ent", "<e2>", ",", "cytomegalovirus", ",", "Kaposi", "sarcoma", "lymphoma", ",", "and", "lung", "cancer"], "h": {"id": "C0004626", "name": "C0004626#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040558", "name": "C0040558#ent", "pos": [17, 18]}}
{"token": ["However", ",", "one", "strain", "(", "97", "-", "209", ")", "expressed", "a", "127-kDa", "C1412999#ent", "<e1>", ",", "suggesting", "that", "chromosomal", "rearrangement", "have", "occurred", "to", "enable", "C1412999#ent", "<e1>", "C0017373#ent", "<e1>", "."], "h": {"id": "C1412999", "name": "C1412999#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017373", "name": "C0017373#ent", "pos": [25, 26]}}
{"token": ["Surprisingly", ",", "treatment", "with", "C1710304#ent", "<e1>", "+", "IFN-gamma", "significantly", "decreased", "C1423842#ent", "<e2>", "adhesion", "and", "emigration", "in", "comparison", "to", "C1710304#ent", "<e1>", "treatment", "alone", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [10, 11]}}
{"token": ["The", "use", "of", "prostanoids", "is", "usually", "reserved", "for", "cases", "of", "Raynaud's", "phenomenon", "associated", "with", "C1290138#ent", "<e1>", "by", "extensive", "C0752352#ent", "<e2>"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0752352", "name": "C0752352#ent", "pos": [18, 19]}}
{"token": ["Transformation", "with", "C2984537#ent", "<e1>", "short", "interfering", "RNA", "abolished", "the", "protective", "effect", "PGI2", "C0221406#ent", "<e2>", "in", "gentamicin-treated", "cells", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [12, 13]}}
{"token": ["The", "hypothalamo-pituitary-adrenal", "axis", "been", "assessed", "in", "17", "C0004096#ent", "<e1>", "children", "before", "and", "after", "long-term", "C0032950#ent", "<e2>", "therapy", "was", "changed", "to", "daily", "corticotrophin", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [14, 15]}}
{"token": ["Apparent", "C0032950#ent", "<e1>", "clearance", "in", "both", "stages", "of", "nephrotic", "syndrome", "greater", "than", "those", "obtained", "in", "C0004096#ent", "<e2>", "children", ",", "possibly", "due", "to", "decreased", "protein", "binding", "C0032950#ent", "<e1>", "in", "nephrotics", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [1, 2]}}
{"token": ["We", "investigated", "platelet-activating", "factor", "migration", "in", "eosinophils", "obtained", "from", "C0004096#ent", "<e1>", "patients", "who", "were", "treated", "with", "without", "intravenous", "C0032950#ent", "<e2>", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "the", "release", "of", "leukotriene", "B4", "calcium", "ionophore", "neutrophils", "from", "C0004096#ent", "<e1>", "patients", "treated", "with", "without", "intravenous", "C0032950#ent", "<e2>", "during", "an", "asthmatic", "attack"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [18, 19]}}
{"token": ["In", "vitro", "analysis", "showed", "that", "Met3Leu", "reduced", "the", "activity", "of", "the", "C0813143#ent", "<e1>", "promoter", "by", "100", "%", "in", "the", "presence", "of", "the", "wild-type", "or", "HSCR-associated", "C0813143#ent", "<e1>", "promoter", "SNP", "C0002085#ent", "<e1>", "."], "h": {"id": "C0813143", "name": "C0813143#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [29, 30]}}
{"token": ["Patients", "with", "known", "causes", "(", "C0025281#ent", "<e1>", "ototoxicity", ",", "tumors", ",", "C0268790#ent", "<e2>", "trauma", ",", "heredity", ",", "autoimmune", "disease", "infection", ")", "were", "compared", "as", "a", "group", "with", "those", "with", "no", "known", "cause", "."], "h": {"id": "C0025281", "name": "C0025281#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [11, 12]}}
{"token": ["The", "serotonin", "syndrome", "result", "from", "coadministration", "of", "pethidine", ",", "C0011816#ent", "<e1>", ",", "pentazocine", "or", "C2350083#ent", "<e2>", "with", "monoamine", "oxidase", "inhibitors", "MAOIs", ")", "or", "selective", "serotonin", "(", "5-hydroxytryptamine", ";", "5-HT", ")", "reuptake", "inhibitors", "SSRIs", ")", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2350083", "name": "C2350083#ent", "pos": [14, 15]}}
{"token": ["C1364160#ent", "<e1>", "is", "a", "glycoprotein", "hormone", "described", "in", "fish", "as", "a", "C0039613#ent", "<e2>", "and", "recently", "its", "mammalian", "counterpart", "has", "been", "identified", "."], "h": {"id": "C1364160", "name": "C1364160#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039613", "name": "C0039613#ent", "pos": [11, 12]}}
{"token": ["X-linked", "hypohidrotic", "ectodermal", "dysplasia", "C1415081#ent", "<e1>", ")", "is", "the", "most", "common", "type", "of", "C0162359#ent", "<e2>"], "h": {"id": "C1415081", "name": "C1415081#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162359", "name": "C0162359#ent", "pos": [13, 14]}}
{"token": ["The", "X-linked", "hypohidrotic", "ectodermal", "dysplasia", "C1415081#ent", "<e1>", ")", "is", "the", "most", "common", "type", "of", "C0162359#ent", "<e2>"], "h": {"id": "C1415081", "name": "C1415081#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162359", "name": "C0162359#ent", "pos": [14, 15]}}
{"token": ["The", "regulation", "of", "the", "gene", "for", "renal", "25-hydroxyvitamin", "D", "1alpha-", "hydroxylase", "1alpha(OH)ase", ";", "C1522417#ent", "<e1>", ")", "by", "parathyroid", "hormone", "PTH", ")", "under", "C0039613#ent", "<e2>", "conditions", "is", "fundamentally", "important", "for", "the", "maintenance", "of", "calcium", "and", "phosphate", "homeostasis"], "h": {"id": "C1522417", "name": "C1522417#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039613", "name": "C0039613#ent", "pos": [22, 23]}}
{"token": ["Such", "effect", "was", "completely", "reversed", "both", "by", "the", "C0027410#ent", "<e1>", "naloxone", "and", "by", "the", "unselective", "muscarinic", "receptor", "antagonist", "C0004259#ent", "<e2>", "."], "h": {"id": "C0027410", "name": "C0027410#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [18, 19]}}
{"token": ["The", "GABAA", "and", "GABAB-receptor/channel", "antagonists", "picrotoxin", "and", "2-hydroxy-saclofen", ",", "the", "C0027410#ent", "<e1>", "naloxone", "and", "C0004259#ent", "<e2>", "failed", "to", "alter", "the", "shape", "of", "the", "frequency-response", "curve"], "h": {"id": "C0027410", "name": "C0027410#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [14, 15]}}
{"token": ["The", "crystal", "structure", "the", "Vbeta8.2-SEC3", "complex", "suggests", "that", "the", "C3538867#ent", "<e1>", "mutations", "act", "by", "disrupting", "Vbeta", "main", "chain", "interactions", "with", "C1420075#ent", "<e2>", ",", "perhaps", "by", "affecting", "the", "conformation", "of", "C3538867#ent", "<e1>", "."], "h": {"id": "C1420075", "name": "C1420075#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3538867", "name": "C3538867#ent", "pos": [9, 10]}}
{"token": ["Deletion", "of", "an", "C0087140#ent", "<e1>", "binding", "site", "intercellular", "adhesion", "molecule-1", "ICAM-1", ")", "promoter", "totally", "abolished", "its", "C0907533#ent", "<e2>", "promoter", "activity", "its", "responsiveness", "to", "TNF-alpha", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [16, 17]}}
{"token": ["C0001361#ent", "<e1>", "and", "pharyngitis", ",", "sometimes", "referred", "to", "together", "as", "C0031350#ent", "<e2>", "are", "among", "the", "most", "common", "of", "the", "individual", "respiratory", "infections"], "h": {"id": "C0001361", "name": "C0001361#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [10, 11]}}
{"token": ["Neither", "cell", "lines", "expressed", "EBV", "C2698739#ent", "<e1>", "mRNA", "at", "detectable", "level", ",", "a", "viral", "gene", "product", "is", "partly", "C1334043#ent", "<e2>", "to", "human", "IL-10", "and", "shares", "biological", "activities", "IL-10", "."], "h": {"id": "C2698739", "name": "C2698739#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["Three", "of", "these", ",", "taking", "a", "higher", "dose", "of", "C0699440#ent", "<e1>", ",", "developed", "resistance", "to", "the", "drug", "'s", "C0003364#ent", "<e2>"], "h": {"id": "C0699440", "name": "C0699440#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [18, 19]}}
{"token": ["C1867981#ent", "<e1>", "DSAP", ")", "is", "a", "C0037274#ent", "<e2>", "usually", "inherited", "in", "an", "autosomal", "dominant", "fashion", "characterized", "by", "numerous", "annular", "papules", "subtle", "raised", "hyperkeratotic", "borders", "and", "slightly", "atrophic", "centers"], "h": {"id": "C1867981", "name": "C1867981#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [6, 7]}}
{"token": ["C1867981#ent", "<e1>", "DSAP", ")", "is", "one", "clinical", "subtype", "porokeratosis", ",", "a", "C0037274#ent", "<e2>", "keratinization", "."], "h": {"id": "C1867981", "name": "C1867981#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [11, 12]}}
{"token": ["The", "activity", "of", "C3539705#ent", "<e1>", "26644", "was", "constantly", "observed", "at", "nontoxic", "doses", "at", "variance", "with", "C0038880#ent", "<e2>", "."], "h": {"id": "C3539705", "name": "C3539705#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [15, 16]}}
{"token": ["In", "the", "cell", "line", "panel", "NF067", "and", "C3539705#ent", "<e1>", "26644", "showed", "activity", "comparable", "with", "C0038880#ent", "<e2>", "."], "h": {"id": "C3539705", "name": "C3539705#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [14, 15]}}
{"token": ["C1619966#ent", "<e1>", "is", "a", "C0034857#ent", "<e2>", "components", "of", "IgG", "and", "cytotoxic", "T-lymphocyte-associated", "antigen-4", "inhibit", "costimulatory", "signal", "antigen", "presenting", "cells", "prevent", "activation", "of", "T", "cells"], "h": {"id": "C1619966", "name": "C1619966#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0034857", "name": "C0034857#ent", "pos": [4, 5]}}
{"token": ["Moreover", ",", "silencing", "of", "Bcl10", ",", "but", "not", "of", "C0010656#ent", "<e1>", "recruitment", "domain-containing", "MAGUK", "protein-1", "(", "C1424244#ent", "<e2>", ")", "induces", "a", "clear", "defect", "in", "TCR-induced", "F-actin", "formation", ",", "cell", "spreading", "and", "conjugate", "formation"], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1424244", "name": "C1424244#ent", "pos": [16, 17]}}
{"token": ["To", "study", "the", "autoimmune", "injuries", "C0011884#ent", "<e1>", "DR", ")", "and", "the", "protective", "effects", "immunosuppressive", "therapy", "cyclosporine", "A", "C0751039#ent", "<e2>", ")", "on", "the", "DR", "of", "streptozotocin", "(STZ)-induced", "diabetic", "rats", "."], "h": {"id": "C0011884", "name": "C0011884#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [17, 18]}}
{"token": ["C0591440#ent", "<e1>", "was", "given", "only", "to", "those", "having", "overt", "C0020676#ent", "<e2>", "with", "diminished", "goiter", "size", "8", "patients", "(", "73", "%", ")", "."], "h": {"id": "C0591440", "name": "C0591440#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [9, 10]}}
{"token": ["The", "biggest", "difference", "was", "observed", "in", "the", "CYP21/C4", "locus", "with", "only", "one", "C1706115#ent", "<e1>", "one", "C4", "gene", ",", "whereas", "in", "human", "and", "mouse", "these", "C0017337#ent", "<e2>", "are", "duplicated", "."], "h": {"id": "C1706115", "name": "C1706115#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}}
{"token": ["C4", "and", "C1706115#ent", "<e1>", "are", "two", "adjacent", ",", "but", "functionally", "unrelated", "C0017337#ent", "<e2>", "residing", "in", "the", "middle", "of", "the", "mammalian", "major", "histocompatibility", "complex", "Mhc", ")", "."], "h": {"id": "C1706115", "name": "C1706115#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["The", "total", "C0524928#ent", "<e1>", "content", "of", "2,4,5-TCP", "after", "C1418449#ent", "<e2>", "treatment", "was", "determined", "to", "be", "228", "+", "/-", "35", "ppm", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418449", "name": "C1418449#ent", "pos": [8, 9]}}
{"token": ["Addition", "of", "a", "crude", "albumin", "fraction", "reduced", "tryptophan", "oxygenase", "induction", "and", "C0011806#ent", "<e1>", "completely", "blocked", "C0027203#ent", "<e2>", "induction", "by", "dexamethasone", "."], "h": {"id": "C0011806", "name": "C0011806#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["Antibodies", "against", "protein", "gene", "product", ",", "C0041491#ent", "<e1>", "dopamine", "beta", "hydroxylase", "choline", "acetyltransferase", "calbindin", "(", "CALB", ")", ",", "calcitonin", "gene-related", "peptide", "C1705783#ent", "<e2>", ")", ",", "and", "nitric", "oxide", "synthase", "used", "to", "characterise", "the", "neurons", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705783", "name": "C1705783#ent", "pos": [21, 22]}}
{"token": ["The", "distribution", "of", "C0041491#ent", "<e1>", "TH", ")", "and", "calcitonin", "gene-related", "peptide", "C1705783#ent", "<e2>", ")", "on", "the", "cochlear", "spiral", "modiolar", "artery", "(", "SMA", ")", "was", "investigated", "in", "the", "guinea", "pig", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705783", "name": "C1705783#ent", "pos": [11, 12]}}
{"token": ["After", "CLP", ",", "C1539081#ent", "<e1>", "KO", "mice", "had", "attenuated", "activation", "of", "nuclear", "factor", "kappaB", "signal", "transducer", "C1422492#ent", "<e2>", "3", "in", "both", "the", "lung", "and", "the", "liver", "."], "h": {"id": "C1539081", "name": "C1539081#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [16, 17]}}
{"token": ["The", "C0038085#ent", "<e1>", "be", "enhanced", "or", "replaced", "by", "other", "promoting", "C0991617#ent", "<e2>", "."], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [10, 11]}}
{"token": ["Previous", "reports", "demonstrated", "that", "C1705526#ent", "<e1>", "represses", "human", "C0087071#ent", "<e2>", "hTERT", ")", ",", "a", "key", "component", "for", "telomerase", "activity"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0087071", "name": "C0087071#ent", "pos": [8, 9]}}
{"token": ["A", "decrease", "in", "distribution", "volumes", "was", "seen", "in", "control", "goats", "with", "sulphadimidine", ",", "C0038744#ent", "<e1>", "and", "C0700599#ent", "<e2>", ",", "but", "was", "only", "significant", "for", "C0700599#ent", "<e2>", "."], "h": {"id": "C0038744", "name": "C0038744#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0700599", "name": "C0700599#ent", "pos": [16, 17]}}
{"token": ["These", "enzymes", "represent", "a", "conserved", "class", "of", "the", "GHMP", "family", "of", "kinases", ",", "which", "includes", "C0016937#ent", "<e1>", ",", "homoserine", "kinase", "mevalonate", "kinase", "and", "phosphomevalonate", "kinase", "with", "C1334043#ent", "<e2>", "in", "plants", "and", "several", "eubacteria", "."], "h": {"id": "C0016937", "name": "C0016937#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [26, 27]}}
{"token": ["Familial", "male-limited", "precocious", "puberty", "C0249071#ent", "<e1>", ")", "is", "a", "form", "of", "C1415169#ent", "<e2>", "isosexual", "precocious", "puberty", "by", "gain-of-function", "mutations", "of", "the", "luteinizing", "hormone/chorionic", "gonadotropin", "receptor", "hLHR", ")", "."], "h": {"id": "C0249071", "name": "C0249071#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "the", "antibody", "bound", "to", "a", "single", "protein", "Mr", "54,000", "in", "the", "microsomal", "fraction", "of", "lymphoblastoid", "cells", "human", "C1620185#ent", "<e1>", ",", "but", "not", "to", "any", "other", "C0010762#ent", "<e2>"], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [28, 29]}}
{"token": ["New", "advances", "that", "are", "covered", "in", "this", "section", "include", "controversies", "in", "long-term", "use", "of", "opioids", "and", "C3540042#ent", "<e1>", "differentiating", "fibromyalgia", ",", "C0027073#ent", "<e2>", "and", "chronic", "fatigue", "syndrome", "pathophysiology", "of", "myofascial", "pain", "and", "beneficial", "treatments", "."], "h": {"id": "C3540042", "name": "C3540042#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027073", "name": "C0027073#ent", "pos": [21, 22]}}
{"token": ["The", "antinociceptive", "effects", "of", "C0771655#ent", "<e1>", "were", "furthermore", "examined", "in", "C0011777#ent", "<e2>"], "h": {"id": "C0771655", "name": "C0771655#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}}
{"token": ["As", "the", "expression", "of", "C1418431#ent", "<e1>", "mirrors", "the", "distribution", "of", "PDE4", "we", "speculate", "that", "this", "C0014442#ent", "<e2>", "could", "be", "a", "target", "for", "novel", "anti-inflammatory", "drugs"], "h": {"id": "C1418431", "name": "C1418431#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["C3665365#ent", "<e1>", "CVD", ")", "and", "C0011875#ent", "<e2>", "been", "associated", "with", "increase", "in", "oxidative", "stress"], "h": {"id": "C3665365", "name": "C3665365#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011875", "name": "C0011875#ent", "pos": [5, 6]}}
{"token": ["C0019693#ent", "<e1>", "entry", "inhibitors", "include", "C2936804#ent", "<e2>", "the", "fusion", "inhibitor", "T-20", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936804", "name": "C2936804#ent", "pos": [5, 6]}}
{"token": ["This", "case", "suggests", "that", "C0264490#ent", "<e1>", "be", "considered", "in", "cases", "of", "C0398367#ent", "<e2>", "associated", "with", "lymphatic", "blockade", "."], "h": {"id": "C0264490", "name": "C0264490#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0398367", "name": "C0398367#ent", "pos": [11, 12]}}
{"token": ["Induction", "of", "steroidogenesis", "by", "isoproterenol", "or", "C0917964#ent", "<e1>", "involved", "de", "novo", "synthesis", "of", "the", "C0010762#ent", "<e2>", "SCC", ")", "enzyme", "complex", "as", "assessed", "by", "indirect", "immunofluorescence", "staining", "adrenodoxin", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [14, 15]}}
{"token": ["The", "treatment", "of", "Y-1", "cells", "with", "dibutyryladenosine", "3',5'-cyclic", "monophosphate", "C0917964#ent", "<e1>", "induced", "the", "transcript", "of", "C0010762#ent", "<e2>", "ferredoxin", "mRNA", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [15, 16]}}
{"token": ["A", "comprehensive", "method", "the", "determination", "of", "methylmercury", "by", "capillary", "gas", "chromatography", "C1367452#ent", "<e1>", ")", "on-line", "coupled", "with", "atomic", "fluorescence", "spectrometry", "C2699751#ent", "<e2>", ")", "was", "developed", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2699751", "name": "C2699751#ent", "pos": [20, 21]}}
{"token": ["One", "patient", "with", "stage", "III", "disease", "treated", "with", "adnexectomy", "plus", "combination", "chemotherapy", "consisting", "of", "C0042671#ent", "<e1>", ",", "bleomycin", ",", "dactinomycin", ",", "C1161438#ent", "<e2>", ",", "and", "cisplatin", "(", "VAB-VI", ")", "."], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [21, 22]}}
{"token": ["Granulocytopenia", "was", "dose-limiting", ",", "and", "recommended", "starting", "doses", "are", "C0042671#ent", "<e1>", "4", "mg/m2", ",", "adriamycin", "40", "mg/m2", ",", "and", "C1161438#ent", "<e2>", "400", "mg/m2", "."], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [19, 20]}}
{"token": ["Visible", "hematopoietic", "colonies", "in", "the", "spleen", "are", "not", "produced", "by", "C0042671#ent", "<e1>", ",", "nitrogen", "mustard", "methotrexate", ",", "or", "C1161438#ent", "<e2>", "."], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [18, 19]}}
{"token": ["Combinations", "of", "interferon", "alfa-2b", "doxorubicin", ",", "cisplatin", ",", "C0042671#ent", "<e1>", ",", "melphalan", "and", "C1161438#ent", "<e2>", "have", "been", "shown", "to", "have", "at", "least", "additive", "and", "occasionally", "synergistic", "antiproliferative", "effects"], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [13, 14]}}
{"token": ["A", "key", "enzyme", "in", "eicosanoid", "biosynthesis", "inflammation", "is", "group", "C1744635#ent", "<e1>", "also", "known", "as", "C1333201#ent", "<e2>", "cPLA2alpha", ")", "."], "h": {"id": "C1744635", "name": "C1744635#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1333201", "name": "C1333201#ent", "pos": [14, 15]}}
{"token": ["Many", "C0040085#ent", "<e1>", "TS", ")", "inhibitors", "undergo", "intracellular", "metabolism", "to", "C0220897#ent", "<e2>", "forms", "which", "can", "significantly", "alter", "their", "activity", "and", "pharmacodynamics", "through", "improved", "TS", "inhibition", "and", "drug", "retention"], "h": {"id": "C0040085", "name": "C0040085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0220897", "name": "C0220897#ent", "pos": [10, 11]}}
{"token": ["The", "inactivation", "of", "pea", "leaf", "chloroplast", "glucose-6-phosphate", "dehydrogenase", "dithiothreitol", "can", "be", "catalyzed", "by", "C2987019#ent", "<e1>", "are", "present", "in", "C3179066#ent", "<e2>", "."], "h": {"id": "C2987019", "name": "C2987019#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [18, 19]}}
{"token": ["We", "have", "characterized", "the", "molecular", "defect", "lecithin", ":", "cholesterol", "acyltransferase", "(", "C1259497#ent", "<e1>", ")", "in", "the", "C1416804#ent", "<e2>", "three", "siblings", "of", "Austrian", "descent", "."], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [16, 17]}}
{"token": ["Incubation", "of", "C1259497#ent", "<e1>", "plasma", "with", "active", "C1416804#ent", "<e2>", "caused", "a", "substantial", "augmentation", "of", "the", "original", "subfraction", "which", "morphologically", "resembled", "normal", "LDL", "."], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [7, 8]}}
{"token": ["Eleven", "patients", "with", "essential", "hypertension", "and", "C0011854#ent", "<e1>", "treated", "with", "isradipine", "or", "C0282138#ent", "<e2>", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [12, 13]}}
{"token": ["Three", "C1142644#ent", "<e1>", "substrates", "were", "selected", "for", "study", ":", "C0011816#ent", "<e2>", "(", "DEM", ")", ",", "midazolam", "(", "MDZ", ")", "and", "diazepam", "(", "DZ", ")", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [1, 2]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "transfection", "of", "PXR", "and", "retinoid", "X", "receptor-alpha", "RXRalpha", ")", "also", "showed", "prominent", "induction", "of", "C1142644#ent", "<e1>", "mRNA", "by", "C0011816#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [16, 17]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [20, 21]}}
{"token": ["Two", "patients", "with", "C0035326#ent", "<e1>", "mid-late", "systolic", "clicks", "on", "cardiac", "auscultation", "suggesting", "the", "diagnosis", "of", "C0026267#ent", "<e2>"], "h": {"id": "C0035326", "name": "C0035326#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026267", "name": "C0026267#ent", "pos": [15, 16]}}
{"token": ["Previous", "studies", "on", "the", "C0052199#ent", "<e1>", "frequency", "in", "C0338451#ent", "<e2>", "have", "been", "inconclusive", "."], "h": {"id": "C0052199", "name": "C0052199#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0338451", "name": "C0338451#ent", "pos": [8, 9]}}
{"token": ["The", "bipyridyl", "ligands", "were", "evaluated", "in", "copper(I)-catalyzed", "cyclopropanation", "reactions", "of", "styrene", "with", "the", "C0014996#ent", "<e1>", "and", "t-butyl", "esters", "of", "C0004480#ent", "<e2>"], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004480", "name": "C0004480#ent", "pos": [19, 20]}}
{"token": ["The", "C0012863#ent", "<e1>", "ellipticine", "inhibited", "the", "synthesis", "of", "C0149678#ent", "<e2>", "polypeptides", "at", "concentrations", "which", "did", "not", "affect", "total", "protein", "synthesis"], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "suggest", "that", "C0012863#ent", "<e1>", "required", "for", "expression", "of", "the", "C0149678#ent", "<e2>", "genome", "and", "that", "both", "topoisomerases", "I", "II", "are", "involved", "in", "replication", "of", "the", "C0149678#ent", "<e2>", "genome", "during", "the", "lytic", "phase", "the", "life", "cycle"], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [11, 12]}}
{"token": ["C1705456#ent", "<e1>", "is", "repressed", "when", "preferred", "nitrogen", "sources", "available", "and", "this", "nitrogen", "catabolite", "repression", "C1705456#ent", "<e1>", "was", "correlated", "with", "downregulation", "of", "C1420514#ent", "<e1>", "in", "the", "presence", "of", "high", "concentrations", "of", "ammonium", ",", "glutamine", "or", "urea", "."], "h": {"id": "C1705456", "name": "C1705456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420514", "name": "C1420514#ent", "pos": [21, 22]}}
{"token": ["Previously", ",", "we", "screened", "the", "human", "C1332082#ent", "<e1>", "variations", "because", "genetic", "variability", "C0003692#ent", "<e2>", "might", "influence", "these", "diseases", "."], "h": {"id": "C1332082", "name": "C1332082#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0003692", "name": "C0003692#ent", "pos": [12, 13]}}
{"token": ["Northern", "blot", "analysis", "marked", "upregulation", "in", "P1", "of", "the", "brain-specific", "protein", "phosphatase", "2A", "beta", "subunit", "PPP2R2B", ")", ",", "a", "causative", "gene", "spinocerebellar", "ataxia", "12", "and", "the", "C1332741#ent", "<e1>", "CDR34", ")", "gene", "associated", "with", "development", "of", "C0393534#ent", "<e2>"], "h": {"id": "C1332741", "name": "C1332741#ent", "pos": [26, 27]}, "relation": "gene_associated_with_disease", "t": {"id": "C0393534", "name": "C0393534#ent", "pos": [35, 36]}}
{"token": ["A", "58", "year", "old", "Chinese", "male", ",", "one", "week", "after", "arriving", "in", "Canada", "from", "Hong", "Kong", "presented", "with", "C0000737#ent", "<e1>", "diarrhoea", "which", "was", "rapidly", "followed", "by", "C0014836#ent", "<e2>", "septicaemia", "and", "meningitis", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014836", "name": "C0014836#ent", "pos": [26, 27]}}
{"token": ["The", "radiation-increased", "expression", "C1704823#ent", "<e1>", "could", "transform", "into", "magnifying", "receptor", "tyrosine", "phosphorylation", "reaction", "and", "C0752312#ent", "<e2>", "once", "the", "ligand", "was", "added", ",", "fairly", "corresponding", "with", "alteration", "in", "the", "receptor", "."], "h": {"id": "C1704823", "name": "C1704823#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [14, 15]}}
{"token": ["The", "dopamine", "drugs", "apomorphine", "and", "d-amphetamine", "caused", "vigorous", "circling", "in", "raphe", "lesioned", "rats", "which", "was", "increased", "further", "by", "C0877830#ent", "<e1>", "but", "antagonized", "by", "C0015827#ent", "<e2>", "."], "h": {"id": "C0877830", "name": "C0877830#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0015827", "name": "C0015827#ent", "pos": [23, 24]}}
{"token": ["The", "exogenous", "addition", "of", "scPLD", "blocked", "the", "up-regulation", "of", "C1333530#ent", "<e1>", "expression", ",", "mitochondrial", "permeability", "and", "the", "cleavages", "of", "procaspase-8", ",", "C0758915#ent", "<e2>", ",", "and", "protein", "kinase", "C-delta"], "h": {"id": "C1333530", "name": "C1333530#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0758915", "name": "C0758915#ent", "pos": [21, 22]}}
{"token": ["We", "chose", "C0211445#ent", "<e1>", "because", "of", "its", "roles", "in", "the", "aging", "process", "C1333237#ent", "<e2>", "and", "ocular", "degeneration", "the", "gene", "disruption"], "h": {"id": "C0211445", "name": "C0211445#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [12, 13]}}
{"token": ["N-terminal", "acetylation", "the", "yeast", "Saccharomyces", "cerevisiae", "catalysed", "by", "any", "of", "three", "C3494445#ent", "<e1>", "NAT", ")", ",", "NatA", ",", "NatB", ",", "and", "C0004135#ent", "<e2>", ",", "which", "contain", "the", "catalytic", "subunits", "Ard1p", "Nat3p", "and", "Mak3p", ",", "respectively", "."], "h": {"id": "C3494445", "name": "C3494445#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [21, 22]}}
{"token": ["The", "nuclear", "distribution", "of", "C1427248#ent", "<e1>", "transcription", "factors", "in", "murine", "C0018939#ent", "<e2>", "examined", "by", "indirect", "immunofluorescence", "."], "h": {"id": "C1427248", "name": "C1427248#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [10, 11]}}
{"token": ["C2981744#ent", "<e1>", "LAPTM4B", ")", "is", "a", "novel", "C0017337#ent", "<e2>", "of", "the", "mammalian", "LAPTM", "family", "and", "has", "been", "shown", "to", "be", "overexpressed", "in", "human", "hepatocellular", "carcinoma"], "h": {"id": "C2981744", "name": "C2981744#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}}
{"token": ["To", "examine", "the", "opiate", "antagonistic", "properties", "of", "low", "doses", "C0174007#ent", "<e1>", ",", "morphine-induced", "C1413682#ent", "<e2>", "was", "challenged", "with", "C0174007#ent", "<e1>", "(", "0", ",", "25", ",", "50", ",", "or", "100", "microg", ")", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0174007", "name": "C0174007#ent", "pos": [9, 10]}}
{"token": ["Morphine-induced", "C1413682#ent", "<e1>", "was", "not", "affected", "by", "C0174007#ent", "<e2>", "at", "these", "doses", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0174007", "name": "C0174007#ent", "pos": [7, 8]}}
{"token": ["Finally", ",", "C1705997#ent", "<e1>", ",", "but", "not", "SRC2", ",", "is", "essential", "for", "C1418596#ent", "<e2>", "induction", "by", "ERbeta", "."], "h": {"id": "C1705997", "name": "C1705997#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418596", "name": "C1418596#ent", "pos": [12, 13]}}
{"token": ["Specific", "esterolytic", "activities", "of", "the", "C1447694#ent", "<e1>", "N-tosyl-L-arginine", "methylester", "(", "TAME", ")", "and", "N-benzoyl-L-arginine", "ethylester", "(", "C0053269#ent", "<e2>", ")", "are", "109.5", "and", "23.6", "mumol/min/mg", ",", "respectively", "."], "h": {"id": "C1447694", "name": "C1447694#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0053269", "name": "C0053269#ent", "pos": [16, 17]}}
{"token": ["C0872913#ent", "<e1>", "also", "stimulated", "the", "synthesis", "of", "C1623430#ent", "<e2>", "mRNA", "and", "protein", "in", "a", "time-dependent", "manner", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [7, 8]}}
{"token": ["Rat", "C1421330#ent", "<e1>", "cDNA", "with", "a", "yeast", "alcohol", "dehydrogenase", "I", "promoter", "and", "C3205287#ent", "<e2>", "was", "integrated", "into", "yeast", "chromosomal", "DNA", "to", "achieve", "the", "stable", "expression", "."], "h": {"id": "C1421330", "name": "C1421330#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3205287", "name": "C3205287#ent", "pos": [12, 13]}}
{"token": ["Consistent", "with", "role", "of", "the", "Ada", "proteins", "positive", "regulation", "of", "C0751383#ent", "<e1>", ",", "deletion", "of", "C1421934#ent", "<e2>", ",", "encoding", "a", "histone", "deacetylase", "prevented", "the", "down", "regulation", "of", "C0751383#ent", "<e1>", "mRNA", "in", "the", "absence", "of", "glucose", "."], "h": {"id": "C1421934", "name": "C1421934#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0751383", "name": "C0751383#ent", "pos": [10, 11]}}
{"token": ["These", "analyses", "revealed", "a", "molecular", "signature", "the", "C1418779#ent", "<e1>", "transcriptional", "network", "and", "identified", "BAF60a", "(", "C1335847#ent", "<e2>", ")", "as", "a", "molecular", "link", "the", "SWI/SNF", "chromatin-remodeling", "complexes", "hepatic", "lipid", "metabolism"], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335847", "name": "C1335847#ent", "pos": [15, 16]}}
{"token": ["Among", "the", "C1417679#ent", "<e1>", "tested", ",", "only", "BRXL1", "can", "replace", "C1705580#ent", "<e2>", "in", "this", "assay", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705580", "name": "C1705580#ent", "pos": [10, 11]}}
{"token": ["The", "cluster", "of", "C1417679#ent", "<e1>", "encoding", "the", "botulinum", "progenitor", "toxin", "the", "upstream", "region", "p21", "and", "C1705580#ent", "<e2>", "were", "divided", "into", "three", "different", "gene", "arrangements", "class", "I-III", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705580", "name": "C1705580#ent", "pos": [15, 16]}}
{"token": ["The", "present", "study", "examined", "the", "effect", "of", "C0172827#ent", "<e1>", "on", "neurotransmission", "of", "capsaicin-sensitive", "calcitonin", "gene-related", "peptide", "(CGRP)-containing", "C0042402#ent", "<e2>", "CGRPergic", "nerves", ")", "in", "rat", "mesenteric", "resistance", "arteries"], "h": {"id": "C0172827", "name": "C0172827#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [17, 18]}}
{"token": ["Hrp3", ",", "a", "paralog", "of", "C1710520#ent", "<e1>", ",", "is", "a", "novel", "member", "of", "the", "C1448753#ent", "<e2>", "(", "chromo-helicase/ATPase-DNA", "binding", "1", "protein", "family", "Schizosaccharomyces", "pombe"], "h": {"id": "C1710520", "name": "C1710520#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1448753", "name": "C1448753#ent", "pos": [14, 15]}}
{"token": ["C0025636#ent", "<e1>", "activity", "was", "also", "completely", "inhibited", "by", "C0033126#ent", "<e2>", ",", "whereas", "24", "%", "inhibition", "was", "noted", "in", "the", "case", "of", "80/53", "at", "the", "same", "concentrations", "."], "h": {"id": "C0025636", "name": "C0025636#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033126", "name": "C0033126#ent", "pos": [8, 9]}}
{"token": ["This", "study", "was", "conducted", "to", "determine", "whether", "C0152256#ent", "<e1>", "induced", "by", "hind-limb", "suspension", "C1705574#ent", "<e2>", ")", "limits", "the", "histopathology", "and", "contractile", "abnormalities", "observed", "in", "the", "dystrophic", "mouse", "."], "h": {"id": "C0152256", "name": "C0152256#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705574", "name": "C1705574#ent", "pos": [13, 14]}}
{"token": ["Slices", "were", "labeled", "with", "[myo-3H]-inositol", ",", "and", "the", "effects", "of", "C0006945#ent", "<e1>", "and", "high", "K+", "on", "the", "formation", "of", "inositol-bisphosphates", "(", "C2697645#ent", "<e2>", ")", "and", "inositol-trisphosphates", "(", "IP3", ")", "were", "determined", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2697645", "name": "C2697645#ent", "pos": [21, 22]}}
{"token": ["In", "the", "m3", ",", "m4", "and", "m5", "transfected", "cells", ",", "C0006945#ent", "<e1>", "appeared", "to", "stimulate", "[3H]inositol", "monophosphate", "(", "C2697645#ent", "<e2>", ")", "accumulation", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2697645", "name": "C2697645#ent", "pos": [18, 19]}}
{"token": ["Proto-oncogenes", "and", "C0017372#ent", "<e1>", "into", "four", "functional", "groups", ":", "growth", "factors", "C0812325#ent", "<e2>", "hormone", "receptors", "signal", "transducers", "and", "transcriptional", "regulatory", "factors"], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [11, 12]}}
{"token": ["Fresh-frozen", "sections", "coronary", "arteries", "also", "available", "from", "six", "of", "the", "19", "hearts", ",", "and", "these", "fresh-frozen", "sections", "immunostained", "for", "the", "p53", "gene", "product", "the", "DO7", "antibody", "and", "for", "C1705522#ent", "<e1>", "using", "the", "anti-WAF1", "antibody", "C1416971#ent", "<e2>", "."], "h": {"id": "C1705522", "name": "C1705522#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1416971", "name": "C1416971#ent", "pos": [34, 35]}}
{"token": ["Central", "vestibular", "dysfunction", "result", "from", "inflammatory", "C0270715#ent", "<e1>", "neoplasia", ",", "trauma", ",", "thiamine", "deficiency", "and", "C0027877#ent", "<e2>"], "h": {"id": "C0270715", "name": "C0270715#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027877", "name": "C0027877#ent", "pos": [15, 16]}}
{"token": ["The", "methionine/valine", "polymorphism", "at", "position", "129", "in", "the", "prion", "protein", "gene", "C1418941#ent", "<e1>", "M129V", ",", "is", "a", "known", "risk", "factor", "C0022336#ent", "<e2>", "CJD", ")", "."], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [20, 21]}}
{"token": ["We", "report", "three", "novel", "mutations", "of", "the", "C1418941#ent", "<e1>", "unrelated", "patients", "with", "clinical", "and", "histopathologic", "features", "of", "C0022336#ent", "<e2>", "."], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [17, 18]}}
{"token": ["Inhibition", "of", "c-Src", "and", "numerous", "intermediates", "along", "the", "C4082284#ent", "<e1>", "ERK", ")", "kinase", "cascade", "Ras", ",", "C0812215#ent", "<e2>", "and", "MEK1/2", "abolished", "the", "CHA-induced", "IKK/NFkappaB", "activation", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [16, 17]}}
{"token": ["25", "patients", "were", "given", "C0011777#ent", "<e1>", "and", "15", "patients", "who", "were", "not", "given", "C0011777#ent", "<e1>", "were", "matched", "for", "age", ",", "sex", ",", "underlying", "C0029896#ent", "<e1>", "and", "clinical", "condition", "per", "the", "evaluation", "scoring"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [23, 24]}}
{"token": ["A", "pharmacokinetic", "data", "analysis", "plasma", "level", "data", "for", "C0011777#ent", "<e1>", "obtained", "from", "children", "with", "various", "C0029896#ent", "<e2>", "and", "healthy", "adults", "performed", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [15, 16]}}
{"token": ["The", "C1421976#ent", "<e1>", "distribution", "reflected", "patchy", "deletion", "of", "C1706016#ent", "<e2>", "in", "the", "lung", "vessels", "aorta", ",", "and", "heart", "of", "SM22alpha;TRE-Cre;R26R;Bmpr1a(flox/+", ")", "and", "flox/flox", "mutants", "."], "h": {"id": "C1421976", "name": "C1421976#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706016", "name": "C1706016#ent", "pos": [8, 9]}}
{"token": ["Different", "responses", "occurred", "when", "the", "vessels", "were", "taken", "from", "patients", "with", "C0007766#ent", "<e1>", "from", "patients", "without", "C1290398#ent", "<e2>"], "h": {"id": "C0007766", "name": "C0007766#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C1290398", "name": "C1290398#ent", "pos": [16, 17]}}
{"token": ["RAD54", "is", "an", "important", "member", "of", "the", "C1419243#ent", "<e1>", "group", "of", "C1417679#ent", "<e2>", "that", "carry", "out", "recombinational", "repair", "DNA", "damage", "the", "yeast", "Saccharomyces", "cerevisiae"], "h": {"id": "C1419243", "name": "C1419243#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "endogenous", "C0242957#ent", "<e1>", "immunoreactivity", "was", "reduced", "in", "cells", "treated", "with", "C0085857#ent", "<e2>", "as", "compared", "with", "the", "levels", "observed", "in", "control", "cells"], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085857", "name": "C0085857#ent", "pos": [13, 14]}}
{"token": ["The", "patient", "was", "a", "48-year-old", "woman", ",", "who", "had", "undergone", "ileocystoplasty", "and", "left", "nephrectomy", "the", "age", "of", "10", "for", "the", "treatment", "of", "C0041296#ent", "<e1>", "contracted", "bladder", "and", "C0041328#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [22, 23]}, "relation": "nichd_parent_of", "t": {"id": "C0041328", "name": "C0041328#ent", "pos": [27, 28]}}
{"token": ["Forty", "years", "ago", "Dastur", "and", "Udani", "described", "a", "form", "of", "diffuse", "cerebral", "damage", "C0041296#ent", "<e1>", ",", "which", "they", "called", "C0041328#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0041328", "name": "C0041328#ent", "pos": [19, 20]}}
{"token": ["Similar", "atypical", "C0040954#ent", "<e1>", "eggs", "have", "been", "reported", "in", "patients", "after", "treatment", "with", "C0025023#ent", "<e2>", ",", "thiabendazole", ",", "tetracloroethylene", ",", "and", "dithiazanine", "."], "h": {"id": "C0040954", "name": "C0040954#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0025023", "name": "C0025023#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "severe", "symptomatic", "C0040954#ent", "<e1>", "observed", "with", "heavy", "worm", "is", "not", "satisfactory", "with", "recommended", "doses", "C0025023#ent", "<e2>", ",", "flubendazole", "and", "albendazole", "."], "h": {"id": "C0040954", "name": "C0040954#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0025023", "name": "C0025023#ent", "pos": [16, 17]}}
{"token": ["Interaction", "between", "Bay-K-8644", "and", "C0028066#ent", "<e1>", ",", "D600", ",", "diltiazem", ",", "papaverine", "or", "C0078437#ent", "<e2>", "on", "a", "K+-contracture", "of", "the", "guinea", "pig", "taenia", "coli", "been", "investigated", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0078437", "name": "C0078437#ent", "pos": [13, 14]}}
{"token": ["The", "peak", "tension", "also", "reduced", "by", "10(-8", ")", "M", "nitroglycerin", ",", "10(-7", ")", "M", "C0028066#ent", "<e1>", ",", "and", "10(-5", ")", "M", "C0078437#ent", "<e2>", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0078437", "name": "C0078437#ent", "pos": [21, 22]}}
{"token": ["This", "effect", "was", "reversed", "by", "the", "Ca++", "channel", "blockers", "verapamil", "and", "C0028066#ent", "<e1>", ",", "and", "the", "Ca++/calmodulin", "inhibitor", ",", "C0078437#ent", "<e2>", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0078437", "name": "C0078437#ent", "pos": [19, 20]}}
{"token": ["C1313359#ent", "<e1>", "OGG1", ")", "is", "a", "C1333237#ent", "<e2>", "enzyme", "that", "excises", "7,8-dihydro-8-oxoguanine", "8oxoG", ")", "from", "DNA", "."], "h": {"id": "C1313359", "name": "C1313359#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [6, 7]}}
{"token": ["The", "DNA", "deficits", "by", "immunosuppressive", "drugs", "the", "C1313359#ent", "<e1>", "polymorphism", "can", "be", "overcome", "by", "the", "delivery", "of", "C1333237#ent", "<e2>", "enzymes", "in", "liposomes", "."], "h": {"id": "C1313359", "name": "C1313359#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "PKC", "alpha", "inhibitor", "C0888599#ent", "<e1>", "induces", "an", "C0014230#ent", "<e2>", "apoptosis", "in", "a", "caspase-independent", "manner", "."], "h": {"id": "C0888599", "name": "C0888599#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014230", "name": "C0014230#ent", "pos": [11, 12]}}
{"token": ["Distamycin", "and", "nitrogen", "mustard", "conjugates", ",", "in", "which", "the", "C0025241#ent", "<e1>", "coupled", "to", "the", "C-terminus", "of", "the", "C3489010#ent", "<e2>", ",", "were", "synthesized", "."], "h": {"id": "C0025241", "name": "C0025241#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3489010", "name": "C3489010#ent", "pos": [17, 18]}}
{"token": ["Basic", "fibroblast", "growth", "factor", "bFGF", ")", "and", "platelet-derived", "growth", "factor", "PDGF", ")", "both", "potentiated", "the", "growth", "of", "C1422315#ent", "<e1>", "in", "culture", ",", "and", "C1515406#ent", "<e2>", "TGF-beta", ")", "inhibited", "C1422315#ent", "<e1>", "proliferation", "."], "h": {"id": "C1422315", "name": "C1422315#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1515406", "name": "C1515406#ent", "pos": [23, 24]}}
{"token": ["The", "majority", "of", "patients", "with", "AIDS", "and", "Pneumocystis", "carinii", "C1535939#ent", "<e1>", "respond", "to", "treatment", "with", "either", "high-dose", "cotrimoxazole", "C0030863#ent", "<e2>"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [9, 10]}, "relation": "may_be_prevented_by", "t": {"id": "C0030863", "name": "C0030863#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "the", "relative", "distribution", "of", "Pneumocystis", "carinii", "the", "lungs", "of", "patients", "with", "C1535939#ent", "<e1>", "to", "see", "the", "effect", "of", "aerosol", "C0030863#ent", "<e2>", "prophylaxis", "on", "this", "distribution", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [13, 14]}, "relation": "may_be_prevented_by", "t": {"id": "C0030863", "name": "C0030863#ent", "pos": [21, 22]}}
{"token": ["C1142644#ent", "<e1>", "and", "CYP2D6", "convert", "C0039286#ent", "<e2>", "to", "N-desmethyltamoxifen", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [5, 6]}}
{"token": ["Dose-related", "increases", "in", "micronuclei", "were", "observed", "when", "cells", "expressing", "2E1", ",", "C1142644#ent", "<e1>", ",", "2D6", "or", "MCL-5", "cells", "were", "exposed", "to", "C0039286#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [21, 22]}}
{"token": ["C0027719#ent", "<e1>", "seems", "to", "be", "increased", "in", "heterozygotes", "as", "well", "(", "C0010641#ent", "<e2>", "%", ")", "but", "rare", "in", "Down", "syndrome", "C0010641#ent", "<e2>", "%", ")", "."], "h": {"id": "C0027719", "name": "C0027719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010641", "name": "C0010641#ent", "pos": [11, 12]}}
{"token": ["Of", "those", "occurrences", "diagnosed", "at", "less", "than", "21", "weeks", "'", "gestation", ",", "the", "ultrasonographic", "features", "of", "fetal", "C0028326#ent", "<e1>", "which", "include", "C1710291#ent", "<e2>", "--", "were", "present", "in", "88.9", "%", "."], "h": {"id": "C0028326", "name": "C0028326#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1710291", "name": "C1710291#ent", "pos": [21, 22]}}
{"token": ["We", "show", "that", "decreased", "C3849574#ent", "<e1>", "pathway", "signaling", "in", "T", "cells", "results", "in", "decreased", "expression", "of", "C0012873#ent", "<e2>", "overexpression", "of", "the", "methylation-sensitive", "genes", "CD11a", "and", "CD70", ",", "similar", "to", "T", "cells", "human", "lupus", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012873", "name": "C0012873#ent", "pos": [16, 17]}}
{"token": ["These", "results", "define", "a", "role", "for", "C2986464#ent", "<e1>", "in", "mediating", "C1539478#ent", "<e2>", "expression", "during", "T", "cell", "activation", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [10, 11]}}
{"token": ["Inhibition", "of", "C2986464#ent", "<e1>", "a", "T", "cell", "hybridoma", "to", "decreased", "C1539478#ent", "<e2>", "expression", "and", "apoptosis", "upon", "T", "cell", "receptor", "stimulation", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [10, 11]}}
{"token": ["Previous", "studies", "have", "suggested", "that", "nuclear", "translocation", "C2986464#ent", "<e1>", "during", "T", "cell", "activation", "is", "a", "critical", "event", "for", "C1539478#ent", "<e2>", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "show", "that", "the", "transcription", "of", "C1423586#ent", "<e1>", "is", "stimulated", "by", "C1166521#ent", "<e2>", "through", "a", "Yap", "consensus", "site", "in", "the", "C1423586#ent", "<e1>", "promoter", "."], "h": {"id": "C1423586", "name": "C1423586#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "C1423586#ent", "<e1>", "did", "not", "result", "in", "sequestration", "of", "C1166521#ent", "<e2>", "in", "membranous", "compartments", "cellular", "iron", "export"], "h": {"id": "C1423586", "name": "C1423586#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [10, 11]}}
{"token": ["Using", "several", "different", "criteria", "we", "demonstrated", "that", "C1423586#ent", "<e1>", "encodes", "a", "transporter", "that", "effects", "the", "accumulation", "of", "C1166521#ent", "<e2>", "and", "Mn(2", "+", ")", "in", "vacuoles", "."], "h": {"id": "C1423586", "name": "C1423586#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [17, 18]}}
{"token": ["No", "significant", "association", "was", "found", "between", "the", "C0720099#ent", "<e1>", "of", "symptoms", "or", "the", "site", "of", "herpes", "zoster", "the", "C0002085#ent", "<e2>", "the", "haplotype", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [18, 19]}}
{"token": ["Therefore", ",", "in", "such", "studies", "cases", "of", "reinfarctions", "are", "either", "to", "be", "excluded", "or", "C1413284#ent", "<e1>", "should", "be", "compared", "with", "modified", "infarction", "size", "(", "C1412384#ent", "<e2>", ")", "."], "h": {"id": "C1413284", "name": "C1413284#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412384", "name": "C1412384#ent", "pos": [24, 25]}}
{"token": ["We", "report", "the", "treatment", "response", "two", "cyclooxygenase-2", "inhibitors", "celecoxib", "and", "C0762662#ent", "<e1>", ",", "in", "a", "series", "of", "patients", "with", "C2349425#ent", "<e2>"], "h": {"id": "C0762662", "name": "C0762662#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2349425", "name": "C2349425#ent", "pos": [19, 20]}}
{"token": ["Our", "patient", "responded", "to", "C3536709#ent", "<e1>", "treatment", "rather", "well", "and", "quickly", ",", "with", "an", "increased", "C1366370#ent", "<e2>", "level", "and", "decreased", "C1366370#ent", "<e2>", "inhibitors", "."], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "cloning", "and", "biological", "activities", "C1258127#ent", "<e1>", "against", "major", "histocompatibility", "complex", "MHC", ")", "class", "II", "transactivator", "C1824738#ent", "<e2>", ")", "so", "as", "to", "explore", "the", "feasibility", "of", "using", "hammerhead", "riboenzyme", "to", "create", "immune", "tolerance"], "h": {"id": "C1258127", "name": "C1258127#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824738", "name": "C1824738#ent", "pos": [18, 19]}}
{"token": ["The", "B-1", "hydrolase", "equal", "affinity", "for", "both", "compounds", ",", "the", "Flavobacterium", "enzyme", "twofold-lower", "affinity", "for", "C1412409#ent", "<e1>", "than", "for", "parathion", ",", "and", "the", "C1334064#ent", "<e2>", "no", "activity", "toward", "C1412409#ent", "<e1>", "."], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1412409", "name": "C1412409#ent", "pos": [15, 16]}}
{"token": ["C0238402#ent", "<e1>", "is", "a", "rare", "C0019247#ent", "<e2>", "characterized", "by", "systemic", "bone", "sclerosis"], "h": {"id": "C0238402", "name": "C0238402#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [5, 6]}}
{"token": ["The", "drug", "uptake", "time-", "and", "dose-dependent", ";", "cell", "preparations", "to", "equal", "concentrations", "of", "either", "drug", "in", "the", "medium", "contained", "a", "twice", "greater", "concentration", "of", "C0008286#ent", "<e1>", "than", "of", "C1418952#ent", "<e2>", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1418952", "name": "C1418952#ent", "pos": [28, 29]}}
{"token": ["(", "1", ")", "Rivastigmine", "is", "the", "third", "C0008429#ent", "<e1>", "to", "be", "approved", "for", "treating", "Alzheimer's", "disease", "after", "C0039245#ent", "<e2>", "and", "donepezil", "."], "h": {"id": "C0008429", "name": "C0008429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039245", "name": "C0039245#ent", "pos": [17, 18]}}
{"token": ["C0752124#ent", "<e1>", "presented", "with", "pure", "C0740279#ent", "<e2>", "MRI", "."], "h": {"id": "C0752124", "name": "C0752124#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0740279", "name": "C0740279#ent", "pos": [5, 6]}}
{"token": ["The", "results", "suggest", "that", "polyglutamine", "expansion", "in", "C0752124#ent", "<e1>", "leads", "to", "neuronal", "death", "C0740279#ent", "<e2>", "reduction", "in", "Ca(2+)", "influx", "into", "Purkinje", "cells", "other", "neurons", "."], "h": {"id": "C0752124", "name": "C0752124#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0740279", "name": "C0740279#ent", "pos": [13, 14]}}
{"token": ["Efavirenz", "(", "EFV", ")", "and", "nevirapine", "(", "C0132326#ent", "<e1>", ")", "are", "metabolized", "by", "cytochrome", "P450", "2B6", "C1382176#ent", "<e2>", ")", "."], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1382176", "name": "C1382176#ent", "pos": [16, 17]}}
{"token": ["C0000981#ent", "<e1>", "treatment", "for", "2", "days", "affected", "only", "the", "C0036572#ent", "<e2>"], "h": {"id": "C0000981", "name": "C0000981#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}}
{"token": ["Recently", ",", "C1420563#ent", "<e1>", "which", "is", "derived", "from", "the", "same", "C0079429#ent", "<e2>", "as", "substance", "P", "has", "been", "found", "in", "visceral", "structures"], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}}
{"token": ["Hepatoerythropoietic", "porphyria", "C0162569#ent", "<e1>", ")", "is", "a", "rare", ",", "autosomal", "recessive", "disorder", "to", "deficient", "C0042085#ent", "<e2>", "activity", "."], "h": {"id": "C0162569", "name": "C0162569#ent", "pos": [2, 3]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0042085", "name": "C0042085#ent", "pos": [14, 15]}}
{"token": ["C0162569#ent", "<e1>", "HEP", ")", "is", "a", "rare", ",", "autosomal", "recessive", "disorder", "to", "deficient", "C0042085#ent", "<e2>", "activity", "."], "h": {"id": "C0162569", "name": "C0162569#ent", "pos": [0, 1]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0042085", "name": "C0042085#ent", "pos": [13, 14]}}
{"token": ["Twenty-three", "Black", "children", "major", "C0019045#ent", "<e1>", "included", "16", "with", "sickle", "cell", "anemia", "two", "with", "C0019021#ent", "<e2>", "CC", ")", ",", "and", "five", "with", "SC", "disease"], "h": {"id": "C0019045", "name": "C0019045#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0019021", "name": "C0019021#ent", "pos": [14, 15]}}
{"token": ["Rad5", "is", "an", "C1335883#ent", "<e1>", "and", "additionally", ",", "it", "functions", "as", "a", "C0077678#ent", "<e2>", "the", "ubiquitin", "conjugation", "reaction"], "h": {"id": "C1335883", "name": "C1335883#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [12, 13]}}
{"token": ["We", "recently", "demonstrated", "that", "specific", "polymorphisms", "in", "Exons", "3", "4", ",", "5", "and", "6", "of", "the", "C1420228#ent", "<e1>", "a", "significant", "different", "allelic", "distribution", "between", "C0010691#ent", "<e2>", "patients", "and", "controls", "."], "h": {"id": "C1420228", "name": "C1420228#ent", "pos": [16, 17]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [24, 25]}}
{"token": ["To", "estimate", "the", "role", "of", "both", "genes", "in", "the", "etiology", "of", "cystinuria", ",", "we", "searched", "for", "sequence", "alterations", "in", "C1420228#ent", "<e1>", "and", "SLC3AI", ":", "30", "unclassified", "C0010691#ent", "<e2>", "were", "investigated", "."], "h": {"id": "C1420228", "name": "C1420228#ent", "pos": [19, 20]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [26, 27]}}
{"token": ["One", "of", "the", "genes", "(", "C1420228#ent", "<e1>", ")", "that", "causes", "C0010691#ent", "<e2>", ",", "an", "inborn", "error", "amino", "acid", "transport", "is", "localized", "to", "19q13", "."], "h": {"id": "C1420228", "name": "C1420228#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [10, 11]}}
{"token": ["Aromatase", "was", "significantly", "higher", "in", "aHPOA", "and", "C0032002#ent", "<e1>", "of", "males", ",", "whereas", "5", "C0055533#ent", "<e2>", "was", "significantly", "higher", "in", "female", "C0032002#ent", "<e1>", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0055533", "name": "C0055533#ent", "pos": [14, 15]}}
{"token": ["Significant", "positive", "correlations", "of", "IL-1", "beta", "C1334119#ent", "<e1>", "with", "the", "platelet", "counts", "documented", "only", "in", "patients", "with", "C3277671#ent", "<e2>", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3277671", "name": "C3277671#ent", "pos": [17, 18]}}
{"token": ["Nail-patella", "syndrome", "NPS", ")", "is", "an", "C2936739#ent", "<e1>", "hereditary", "disorder", "by", "nail", "dysplasia", "patellar", "apoplasia/hypoplasia", "iliac", "horns", "elbow", "dysplasia", "and", "frequently", "C0339573#ent", "<e2>", "progressive", "nephropathy", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [21, 22]}}
{"token": ["Of", "72", "consecutive", "renal", "biopsies", "C0086445#ent", "<e1>", "46", "(", "64", "per", "cent", ")", "had", "C1823282#ent", "<e2>", "changes", "."], "h": {"id": "C0086445", "name": "C0086445#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1823282", "name": "C1823282#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "how", "the", "SP", "concentration", "affects", "C1420565#ent", "<e1>", "trafficking", "and", "determined", "the", "role", "of", "C0752065#ent", "<e2>", "trafficking", "."], "h": {"id": "C1420565", "name": "C1420565#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752065", "name": "C0752065#ent", "pos": [15, 16]}}
{"token": ["For", "C1419385#ent", "<e1>", "the", "meta", "I-meta", "II", "conformational", "transition", "studied", "in", "egg", "phosphatidylcholine", "C1418943#ent", "<e2>", ")", "recombinants", "versus", "the", "native", "rod", "outer", "segment", "ROS", ")", "membranes", "by", "means", "of", "flash", "photolysis"], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [13, 14]}}
{"token": ["The", "human", "C1705513#ent", "<e1>", "known", "to", "have", "paralogous", "relationships", "the", "C3273395#ent", "<e2>", ",", "BRDT", ",", "and", "HUNK1", "genes"], "h": {"id": "C1705513", "name": "C1705513#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273395", "name": "C3273395#ent", "pos": [10, 11]}}
{"token": ["Patients", "suffering", "from", "various", "renal", "diseases", "significantly", "higher", "activities", "of", "the", "C0005270#ent", "<e1>", "than", "individuals", "with", "essential", "hypertension", "or", "other", "C0012634#ent", "<e2>", "."], "h": {"id": "C0005270", "name": "C0005270#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "the", "refeeding", "responses", "other", "lipogenic", "enzymes", ",", "C1970419#ent", "<e1>", "ATP", "citrate", "lyase", "malic", "enzyme", "glucose-6-phosphate", "dehydrogenase", "and", "C1419703#ent", "<e2>", "were", "completely", "abolished", "in", "SREBP-1(-/-", ")", "mice", "."], "h": {"id": "C1970419", "name": "C1970419#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419703", "name": "C1419703#ent", "pos": [19, 20]}}
{"token": ["C1861303#ent", "<e1>", "BS", ")", "is", "an", "C0019247#ent", "<e2>", "by", "granulomatous", "polyarthritis", "panuveitis", ",", "and", "exanthema", "."], "h": {"id": "C1861303", "name": "C1861303#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [6, 7]}}
{"token": ["Western", "analysis", "the", "presence", "of", "VEGF", ",", "C1522505#ent", "<e1>", ",", "PDGF", ",", "TGF-beta(1", ")", ",", "fibronectin", "and", "C1710292#ent", "<e2>", "in", "whole", "CF-CM", "."], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1710292", "name": "C1710292#ent", "pos": [17, 18]}}
{"token": ["Histamine", "H2", "receptor", "antagonist", "C0600832#ent", "<e1>", "and", "cimetidine", "are", "commonly", "used", "for", "treatment", "of", "C0017178#ent", "<e2>"], "h": {"id": "C0600832", "name": "C0600832#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [14, 15]}}
{"token": ["In", "none", "of", "the", "cases", "did", "C0008783#ent", "<e1>", "seem", "to", "provide", "a", "treatment", "of", "C0020502#ent", "<e2>", ",", "a", "condition", "which", "remains", "curable", "with", "surgery", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020502", "name": "C0020502#ent", "pos": [14, 15]}}
{"token": ["Results", "are", "compared", "with", "those", "obtained", "through", "the", "classical", "GNM", "and", "C1854380#ent", "<e1>", "approaches", "applied", "to", "networks", "of", "C0256371#ent", "<e2>"], "h": {"id": "C1854380", "name": "C1854380#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0256371", "name": "C0256371#ent", "pos": [18, 19]}}
{"token": ["C1707870#ent", "<e1>", "was", "found", "to", "interact", "strongly", "with", "the", "human", "C3538741#ent", "<e2>", "hMSH2", ",", "suggesting", "its", "involvement", "in", "the", "MMR", "process", "and/or", "DNA", "recombination"], "h": {"id": "C1707870", "name": "C1707870#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538741", "name": "C3538741#ent", "pos": [10, 11]}}
{"token": ["T", "suppressor", "derived", "from", "immunologically", "unresponsive", "C0023348#ent", "<e1>", "patients", "are", "antigen-specific", ",", "C1706438#ent", "<e2>", "HLA-DQ", "restricted", ",", "and", "produce", "predominantly", "IL-4", ",", "and", "were", "designated", "Type", "2", "CD8", "cells"], "h": {"id": "C0023348", "name": "C0023348#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [12, 13]}}
{"token": ["Current", "data", "are", "inadequate", "to", "draw", "conclusions", "on", "the", "comparative", "efficacy", "C0016384#ent", "<e1>", "and", "castration", ",", "while", "C0068771#ent", "<e2>", "is", "not", "licensed", "for", "monotherapy", "."], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0068771", "name": "C0068771#ent", "pos": [17, 18]}}
{"token": ["Bicalutamide", "has", "an", "affinity", "two", "to", "four", "times", "higher", "than", "2-hydroxyflutamide", ",", "the", "active", "metabolite", "C0016384#ent", "<e1>", ",", "and", "around", "two", "times", "higher", "than", "C0068771#ent", "<e2>", "for", "wild-type", "rat", "and", "human", "prostate", "androgen", "receptors"], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0068771", "name": "C0068771#ent", "pos": [24, 25]}}
{"token": ["A", "regulatory", "network", "of", "transcription", "factors", "PU.1", ",", "C2346452#ent", "<e1>", ",", "E2A", ",", "EBF", ",", "and", "C1335193#ent", "<e2>", "control", "B", "cell", "specification", "and", "differentiation", "."], "h": {"id": "C2346452", "name": "C2346452#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335193", "name": "C1335193#ent", "pos": [16, 17]}}
{"token": ["Forced", "expression", "of", "C1426208#ent", "<e1>", "inhibits", "STAT5", "activation", "by", "binding", "to", "C1333197#ent", "<e2>", "whereas", "CIS3", "and", "JAB", "directly", "binds", "to", "the", "kinase", "domain", "JAKs", ",", "thereby", "inhibiting", "tyrosine", "kinase", "activity"], "h": {"id": "C1426208", "name": "C1426208#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333197", "name": "C1333197#ent", "pos": [11, 12]}}
{"token": ["C0221406#ent", "<e1>", "of", "mucus", "and", "of", "mucin", "glycoproteins", "goblet", "cell", "hyperplasia", "in", "C0600260#ent", "<e2>", "including", "asthma", "and", "cystic", "fibrosis"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0600260", "name": "C0600260#ent", "pos": [12, 13]}}
{"token": ["Dysfunction", "of", "these", "nerves", "may", "contribute", "to", "allergic", "rhinitis", "C0009450#ent", "<e1>", "nasal", "hyperresponsiveness", "and", "possibly", "C0037199#ent", "<e2>", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [15, 16]}}
{"token": ["Almost", "all", "of", "the", "patients", "presented", "common", "C0009450#ent", "<e1>", "which", "were", ":", "pneumonia", ",", "otitis", ",", "diarrhea", ",", "C0037199#ent", "<e2>", ",", "and", "arthritis", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [18, 19]}}
{"token": ["Traditional", "staining", "methods", "plus", "indirect", "immunoperoxidase", "techniques", "IgE", "and", "C0147080#ent", "<e1>", "MCTr", ")", "were", "used", "to", "study", "the", "mast", "cells", "C1425386#ent", "<e2>", ")", "of", "multiple", "sclerosis", "MS", ")", "and", "normal", "brains"], "h": {"id": "C0147080", "name": "C0147080#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425386", "name": "C1425386#ent", "pos": [20, 21]}}
{"token": ["The", "induction", "of", "this", "systemic", "T", "cell", "tolerance", "required", "the", "expression", "of", "C0015923#ent", "<e1>", "ligand", "on", "the", "C0033036#ent", "<e2>", "as", "well", "as", "the", "expression", "of", "C0015923#ent", "<e1>", "on", "the", "T", "cells"], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0015923", "name": "C0015923#ent", "pos": [12, 13]}}
{"token": ["Mutating", "either", "T", "or", "LEF/TCF", "sites", "in", "the", "C3815532#ent", "<e1>", "promoter", "abolishes", "reporter", "gene", "in", "vitro", "well", "as", "in", "the", "tail", "bud", "C1333570#ent", "<e2>", "of", "transgenic", "embryos", "."], "h": {"id": "C3815532", "name": "C3815532#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [22, 23]}}
{"token": ["Activation", "of", "the", "C1370600#ent", "<e1>", "pathway", "was", "indeed", "blocked", "by", "C1333653#ent", "<e2>", "tyrosine", "614F", "and", "slightly", "increased", "by", "Gab2", "serine", "623A", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333653", "name": "C1333653#ent", "pos": [10, 11]}}
{"token": ["Recombinant", "DNA", "clones", "used", "to", "map", "the", "C1420192#ent", "<e1>", "a", "region", "between", "the", "C1564098#ent", "<e2>", "and", "C", "mu", "segment", "the", "locus", "."], "h": {"id": "C1420192", "name": "C1420192#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1564098", "name": "C1564098#ent", "pos": [13, 14]}}
{"token": ["A", "total", "of", "22", "C0017337#ent", "<e1>", "had", "altered", "expression", "in", "MCF-7", "cells", "both", "C1822725#ent", "<e2>", "and", "TCDD", "exposure", ",", "and", "a", "total", "of", "29", "C0017337#ent", "<e1>", "had", "altered", "expression", "in", "HepG2", "cells"], "h": {"id": "C1822725", "name": "C1822725#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}}
{"token": ["C0074554#ent", "<e1>", "also", "induced", "immunoreactivity", "for", "C1704467#ent", "<e2>", ",", "an", "anti-apoptotic", "factor", "on", "one", "hand", ",", "and", "down-regulated", "immunoreactivity", "for", "Bax", ",", "a", "proapoptotic", "factor", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "chronic", "C0074554#ent", "<e1>", "treatment", "significantly", "increased", "C1704467#ent", "<e2>", "mRNA", "and", "protein", "levels", "challenge", "resulted", "in", "a", "significant", "reduction", "in", "Bcl-2", "protein", "abundance", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [9, 10]}}
{"token": ["The", "Ang", "II", "infusion", "induced", "mRNA", "expression", "of", "C3538682#ent", "<e1>", ",", "as", "well", "as", "C3538682#ent", "<e1>", "and", "cytosolic", "PGE", "synthase", "in", "the", "aortas", "as", "assessed", "by", "real-time", "RT-PCR"], "h": {"id": "C3538682", "name": "C3538682#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3538682", "name": "C3538682#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "COP1", "physically", "interacts", "with", "C3538682#ent", "<e1>", "and", "is", "required", "for", "the", "optimum", "accumulation", "of", "C3538682#ent", "<e1>", "light-grown", "seedlings", "."], "h": {"id": "C3538682", "name": "C3538682#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3538682", "name": "C3538682#ent", "pos": [6, 7]}}
{"token": ["Two", "Wilms", "tumor-suppressor", "genes", "C0694898#ent", "<e1>", "and", "WT2", ",", "are", "located", "on", "C0812435#ent", "<e2>", "WT2", "at", "11p15.5", "close", "to", "the", "IGF-II", "gene", "which", "is", "highly", "expressed", "in", "some", "Wilms", "tumors"], "h": {"id": "C0694898", "name": "C0694898#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812435", "name": "C0812435#ent", "pos": [12, 13]}}
{"token": ["The", "initial", "infection", "with", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "in", "most", "individuals", "usually", "results", "in", "the", "establishment", "of", "a", "latent", "or", "C0151317#ent", "<e1>", "eventual", "progression", "toward", "C0001175#ent", "<e2>"], "h": {"id": "C0151317", "name": "C0151317#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [28, 29]}}
{"token": ["The", "para-nitrophenol", "hydroxylase", "erythromycin", "N-demethylase", "and", "C0051169#ent", "<e1>", "omega-1", "hydroxylase", "activities", "were", "significantly", "inhibited", "by", "1", "mM", "C0051696#ent", "<e2>", "in", "both", "noninduced", "and", "induced", "microsomes", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [17, 18]}}
{"token": ["The", "para-nitrophenol", "hydroxylase", "erythromycin", "N-demethylase", "and", "lauric", "acid", "omega", "C0051169#ent", "<e1>", "activities", "were", "significantly", "inhibited", "by", "1", "mM", "C0051696#ent", "<e2>", "in", "both", "noninduced", "and", "induced", "microsomes", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [18, 19]}}
{"token": ["Functional", "signal", "transduction", "through", "C1332802#ent", "<e1>", "in", "PKH-26(dim", ")", "CBTL", "is", "supported", "by", "detectable", "CD28-mediated", "C2936824#ent", "<e2>", "after", "PKH-26(dim", ")", "CBTL", "'s", "exposure", "to", "alloantigen", "or", "C1332802#ent", "<e1>", "cross-linking", "."], "h": {"id": "C1332802", "name": "C1332802#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [15, 16]}}
{"token": ["C1332802#ent", "<e1>", "binds", "to", "several", "intracellular", "proteins", "C2936824#ent", "<e2>", "Pl3-kinase", ")", ",", "the", "tyrosine", "kinase", "ITK", "the", "growth", "factor", "receptor-bound", "protein/Son", "of", "Sevenless", "(", "GRB-2/SOS", ")", "complex", "."], "h": {"id": "C1332802", "name": "C1332802#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [7, 8]}}
{"token": ["The", "effects", "of", "antiarrhythmic", "drugs", "aprindine", ",", "C0543459#ent", "<e1>", "and", "lidocaine", ",", "on", "rat", "erythrocytes", ",", "isolated", "rat", "C0669372#ent", "<e2>", "and", "DPPC-liposomes", "were", "studied", "at", "various", "concentrations", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}}
{"token": ["A", "completely", "different", "pathogenetic", "model", "cardiac", "manifestation", "C0442893#ent", "<e1>", "by", "deficiencies", "of", "various", "C3541394#ent", "<e2>", "in", "a", "variety", "of", "metabolic", "pathways"], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "emphasize", "the", "need", "to", "consider", "all", "elderly", "patients", "with", "C0002896#ent", "<e1>", "candidates", "for", "C0221018#ent", "<e2>", ",", "especially", "if", "pyridoxine", "responsiveness", "is", "demonstrated", "."], "h": {"id": "C0002896", "name": "C0002896#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0221018", "name": "C0221018#ent", "pos": [15, 16]}}
{"token": ["C0002896#ent", "<e1>", "XLSA", ")", "is", "caused", "by", "mutations", "in", "the", "C0221018#ent", "<e2>", "ALAS2", ")", "gene", "."], "h": {"id": "C0002896", "name": "C0002896#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0221018", "name": "C0221018#ent", "pos": [10, 11]}}
{"token": ["C0108121#ent", "<e1>", "more", "inhibitory", "than", "C0142874#ent", "<e2>", "the", "growth", "of", "B.", "cereus", "was", "inhibited", "at", "1.5", "and", "3", "%", "concentrations", "at", "20", "degrees", "C", ",", "respectively", "."], "h": {"id": "C0108121", "name": "C0108121#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0142874", "name": "C0142874#ent", "pos": [5, 6]}}
{"token": ["We", "have", "identified", "and", "cloned", "a", "novel", "gene", "(", "C2985242#ent", "<e1>", ")", "from", "the", "human", "C0012236#ent", "<e2>"], "h": {"id": "C2985242", "name": "C2985242#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0012236", "name": "C0012236#ent", "pos": [15, 16]}}
{"token": ["Examination", "of", "our", "patients", "1", "-", "3", "years", "after", "the", "accident", "showed", "no", "sign", "C0847483#ent", "<e1>", "little", "residual", "C0231218#ent", "<e2>", "."], "h": {"id": "C0847483", "name": "C0847483#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [18, 19]}}
{"token": ["This", "study", "examined", "the", "acute", "and", "long-term", "effects", "of", "C0026256#ent", "<e1>", "pacing", "on", "ergospirometric", "parameters", "and", "neurohormonal", "activity", "patients", "with", "C0007194#ent", "<e2>", "HOCM", ")", "."], "h": {"id": "C0026256", "name": "C0026256#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007194", "name": "C0007194#ent", "pos": [20, 21]}}
{"token": ["The", "issue", "of", "C0026256#ent", "<e1>", "pacing", "as", "a", "therapeutic", "option", "for", "patients", "with", "C0007194#ent", "<e2>", "still", "under", "debate", "."], "h": {"id": "C0026256", "name": "C0026256#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007194", "name": "C0007194#ent", "pos": [13, 14]}}
{"token": ["Alterations", "in", "parathyroid", "glandular", "sensitivity", "to", "C2936886#ent", "<e1>", "may", "contribute", "to", "the", "C0037036#ent", "<e2>", "of", "PTH", "in", "hyperparathyroidism", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037036", "name": "C0037036#ent", "pos": [12, 13]}}
{"token": ["Three", "of", "those", ",", "COL4A3", ",", "C1413585#ent", "<e1>", ",", "and", "COL4A5", ",", "are", "linked", "with", "Alport", "syndrome", "C0027706#ent", "<e2>", "."], "h": {"id": "C1413585", "name": "C1413585#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027706", "name": "C0027706#ent", "pos": [17, 18]}}
{"token": ["Parvovirus", "B19", "known", "to", "cause", "erythema", "infection", "fifth", "disease", ",", "acute", "and", "C0263680#ent", "<e1>", "aplastic", "crises", "in", "chronic", "hemolytic", "anemia", "C0581384#ent", "<e2>", "the", "immunocompromised", "host", "and", "hydrops", "fetalis"], "h": {"id": "C0263680", "name": "C0263680#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0581384", "name": "C0581384#ent", "pos": [20, 21]}}
{"token": ["First", ",", "a", "diagnosis", "of", "C0154723#ent", "<e1>", "may", "be", "missed", "in", "the", "presence", "of", "other", "C0018681#ent", "<e2>", "types", "that", "occur", "proportionally", "more", "frequently", "than", "C0154723#ent", "<e1>", "and", "thereby", "overshadow", "C0154723#ent", "<e1>", "."], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [15, 16]}}
{"token": ["Depending", "on", "the", "pattern", ",", "the", "histamine-1", "antagonist", "C0012522#ent", "<e1>", ",", "the", "5-hydroxytryptamine-2", "antagonist", "ketanserin", "and", "the", "cyclooxygenase", "inhibitor", "C0031990#ent", "<e2>", "also", "reduced", "the", "responses", "."], "h": {"id": "C0012522", "name": "C0012522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [19, 20]}}
{"token": ["C0165901#ent", "<e1>", "augmented", "the", "maximal", "response", "to", "C2744579#ent", "<e2>", "without", "affecting", "the", "EC50", "value", "of", "C2744579#ent", "<e2>", "."], "h": {"id": "C0165901", "name": "C0165901#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [7, 8]}}
{"token": ["Application", "of", "differential-pulse", "cathodic", "stripping", "voltammetry", "using", "a", "carbon", "paste", "electrode", "consisting", "of", "C0524928#ent", "<e1>", "powder", "and", "C0727050#ent", "<e2>", "have", "been", "investigated", "for", "trace", "determination", "iron", "in", "5-aminoisophthalic", "acid", "AIPA", ")", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0727050", "name": "C0727050#ent", "pos": [17, 18]}}
{"token": ["Transfection", "of", "HUVECs", "with", "C1823924#ent", "<e1>", "expression", "vector", "activated", "the", "expression", "of", "C0694872#ent", "<e2>", "and", "cdh19", "genes", "."], "h": {"id": "C1823924", "name": "C1823924#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "knockdown", "of", "C1823924#ent", "<e1>", "also", "significantly", "suppressed", "MCP-1-induced", "C0694872#ent", "<e2>", "and", "cdh19", "gene", "expression", "."], "h": {"id": "C1823924", "name": "C1823924#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [10, 11]}}
{"token": ["C1957666#ent", "<e1>", "potently", "inhibited", "C1704823#ent", "<e2>", "phosphorylation", "and", "c-Met-dependent", "proliferation", ",", "migration", ",", "or", "invasion", "of", "human", "tumor", "cells", "in", "vitro", "IC(50", ")", "values", ",", "5", "-", "20", "nmol/L", ")", "."], "h": {"id": "C1957666", "name": "C1957666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704823", "name": "C1704823#ent", "pos": [4, 5]}}
{"token": ["C1704375#ent", "<e1>", "commonly", "an", "X-linked", "dominant", "disorder", "C3536984#ent", "<e2>", "or", "HYP", ")", "associated", "with", "renal", "tubular", "defect", "phosphate", "transport", "bone", "deformities"], "h": {"id": "C1704375", "name": "C1704375#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536984", "name": "C3536984#ent", "pos": [7, 8]}}
{"token": ["In", "C1704375#ent", "<e1>", "there", "are", "both", "inherited", "and", "acquired", "forms", "where", "X-linked", "dominant", "hypophosphatemic", "rickets", "C3536984#ent", "<e2>", ")", "is", "the", "most", "prevalent", "genetic", "form", "caused", "by", "mutations", "in", "the", "phosphate-regulating", "endopeptidase", "PHEX", ")", "gene", "."], "h": {"id": "C1704375", "name": "C1704375#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536984", "name": "C3536984#ent", "pos": [15, 16]}}
{"token": ["T", "lymphocyte", "activation", "through", "the", "T", "cell", "receptor", "complex", "alters", "the", "avidity", "of", "the", "C1332871#ent", "<e1>", "for", "its", "ligand", "C1332715#ent", "<e2>", "."], "h": {"id": "C1332871", "name": "C1332871#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332715", "name": "C1332715#ent", "pos": [19, 20]}}
{"token": ["C0040374#ent", "<e1>", "(", "TOLB", ")", "is", "a", "C0038766#ent", "<e2>", "used", "to", "treat", "non-insulin-dependent", "diabetes", "mellitus", "is", "a", "suspected", "teratogen", "."], "h": {"id": "C0040374", "name": "C0040374#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [7, 8]}}
{"token": ["Meglitinide", "and", "C0040374#ent", "<e1>", ",", "which", "represent", ",", "respectively", ",", "the", "benzamido", "and", "C0038766#ent", "<e2>", "glibenclamide", ",", "showed", "Hill", "coefficients", "0.8", "+", "/-", "0.1", "and", "0.9", "+", "/-", "0.1", ",", "respectively", "."], "h": {"id": "C0040374", "name": "C0040374#ent", "pos": [2, 3]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [13, 14]}}
{"token": ["Since", "C1538127#ent", "<e1>", "expression", "is", "induced", "by", "C1415900#ent", "<e2>", ",", "we", "utilized", "Sindbis", "virus", "SINV", ")", "to", "investigate", "the", "role", "of", "other", "IFN-induced", "factors", "in", "ZAP", "'s", "inhibitory", "potential", "."], "h": {"id": "C1538127", "name": "C1538127#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [7, 8]}}
{"token": ["The", "new", "indications", "for", "SCS", "are", "end-stage", "peripheral", "vascular", "disease", "C0151744#ent", "<e1>", "whereas", "PNS", "is", "used", "for", "the", "treatment", "of", "occipital", "neuralgia", "C0030794#ent", "<e2>"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030794", "name": "C0030794#ent", "pos": [22, 23]}}
{"token": ["Tyrosine", "hydroxylase", "C1420718#ent", "<e1>", ")", "expression", "increases", "in", "adrenal", "chromaffin", "cells", "treated", "with", "nicotinic", "agonist", "C0012847#ent", "<e2>", "(", "DMPP", ";", "1", "microM", ")", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012847", "name": "C0012847#ent", "pos": [15, 16]}}
{"token": ["Highly", "type-specific", "soluble", "antigens", "C1825840#ent", "<e1>", ")", "of", "viruses", "of", "the", "tick-borne", "encephalitis", "C3540638#ent", "<e2>", ")", "complex", "were", "obtained", "by", "treatment", "of", "the", "sucrose-acetone", "antigens", "with", "8", "mol/l", "urea", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540638", "name": "C3540638#ent", "pos": [13, 14]}}
{"token": ["The", "serum", "to", "C1825840#ent", "<e1>", "of", "strain", "Sofyin", "and", "of", "Omsk", "haemorrhagic", "fever", "virus", "the", "C3540638#ent", "<e2>", "complex", "representatives", ";", "the", "difference", "between", "homologous", "serum", "titres", "in", "the", "range", "of", "4", "-", "5", "two-fold", "dilution", "steps", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540638", "name": "C3540638#ent", "pos": [15, 16]}}
{"token": ["Twenty-three", "patients", "with", "primary", "hypercholesterolemia", "C0155210#ent", "<e1>", ",", "including", "11", "patients", "with", "heterozygous", "C0745103#ent", "<e2>", "were", "treated", "with", "pravastatin", "(", "20", "mg/day", ")", "or", "probucol", "(", "1000", "mg/day", ")", "for", "24", "months", "."], "h": {"id": "C0155210", "name": "C0155210#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0745103", "name": "C0745103#ent", "pos": [13, 14]}}
{"token": ["Onpi-to", "includes", "1.240", "%", "of", "total", "potential", "C0073177#ent", "<e1>", "derived", "from", "C0141981#ent", "<e2>", "sennoside", "B", "C0073177#ent", "<e1>", "8-O-glucopyranoside", "and", "C0073177#ent", "<e1>", "."], "h": {"id": "C0141981", "name": "C0141981#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0073177", "name": "C0073177#ent", "pos": [7, 8]}}
{"token": ["Based", "on", "median", "values", ",", "0.007", "%", "of", "the", "C0141981#ent", "<e1>", "intake", "(", "calculated", "as", "C0073177#ent", "<e2>", ")", "was", "excreted", "in", "breast", "milk"], "h": {"id": "C0141981", "name": "C0141981#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0073177", "name": "C0073177#ent", "pos": [15, 16]}}
{"token": ["Our", "patient", ",", "a", "26-year-old", "woman", "with", "systemic", "lupus", "erythematosus", "developed", "C3266102#ent", "<e1>", "exertional", "dyspnea", "pulmonary", "fibrosis", "without", "proteinuria", "or", "the", "C0027726#ent", "<e2>"], "h": {"id": "C3266102", "name": "C3266102#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [21, 22]}}
{"token": ["To", "determine", "whether", "C1334126#ent", "<e1>", "is", "involved", "in", "the", "early", "formation", "of", "C0004153#ent", "<e2>", ",", "leukocyte-specific", "CXCR2(-/-", ")", "chimeric", "mice", "on", "LDLR(-/-", ")", "background", "were", "generated", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}}
{"token": ["Blockade", "of", "Mif", "but", "not", "of", "canonical", "ligands", "C1334126#ent", "<e1>", "or", "Cxcr4", "in", "mice", "with", "advanced", "C0004153#ent", "<e2>", "led", "to", "plaque", "regression", "and", "reduced", "monocyte", "and", "T-cell", "content", "in", "plaques", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [16, 17]}}
{"token": ["In", "a", "time-course", "study", ",", "the", "correlation", "between", "symptoms", "and", "degree", "of", "C0014894#ent", "<e1>", "inhibition", "was", "examined", "in", "rats", "administered", "the", "minimum", "lethal", "dose", "C3539689#ent", "<e2>", ":", "1000", "mg/kg", "b.w", ".", ")"], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539689", "name": "C3539689#ent", "pos": [24, 25]}}
{"token": ["C0016751#ent", "<e1>", "HFI", ")", "is", "a", "rare", "autosomally", "recessive", "disease", "leads", "to", "severe", "C0020615#ent", "<e2>", "."], "h": {"id": "C0016751", "name": "C0016751#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [13, 14]}}
{"token": ["The", "C1420729#ent", "<e1>", "Sp1", "polymorphism", "has", "been", "associated", "with", "bone", "mineral", "density", "C0339510#ent", "<e2>", ")", "and", "fracture", "."], "h": {"id": "C1420729", "name": "C1420729#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0339510", "name": "C0339510#ent", "pos": [12, 13]}}
{"token": ["We", "confirm", "that", "the", "C1420729#ent", "<e1>", "Sp1", "polymorphism", "influences", "C0339510#ent", "<e2>", "and", "the", "risk", "of", "fracture", "in", "postmenopausal", "Caucasian", "women", "."], "h": {"id": "C1420729", "name": "C1420729#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0339510", "name": "C0339510#ent", "pos": [9, 10]}}
{"token": ["C0006949#ent", "<e1>", "has", "this", "characteristic", "common", "with", "C0003289#ent", "<e2>"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [7, 8]}}
{"token": ["These", "include", "lithium", ";", "electroconvulsive", "therapy", "C0006949#ent", "<e1>", "or", "valproic", "acid", "benzodiazepines", ";", "C0003289#ent", "<e2>", "reserpine", ";", "L-dopa", "and", "amphetamine", ";", "opioid", "drugs", "calcium", "channel", "blockers", "and", "miscellaneous", "other", "pharmacologic", "approaches", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [6, 7]}, "relation": "has_therapeutic_class", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [13, 14]}}
{"token": ["Two", "of", "the", "recently", "described", "mutations", ",", "N93", "K", "and", "R702C", ",", "are", "conserved", "in", "smooth", "and", "C0949646#ent", "<e1>", "vertebrates", "and", "lie", "in", "the", "head", "domain", "C0027096#ent", "<e2>", "."], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [26, 27]}}
{"token": ["As", "the", "weight", "ratio", "actin", "to", "heat-treated", "C0949646#ent", "<e1>", "increased", ",", "the", "rate", "of", "early", "inactivation", "of", "C0027096#ent", "<e2>", "increased", "."], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [17, 18]}}
{"token": ["2", ")", "p90RSK", "activation", "by", "H(2)O(2", ")", "was", "significantly", "reduced", "in", "fibroblasts", "derived", "from", "transgenic", "mice", "deficient", "in", "C1442788#ent", "<e1>", ",", "but", "not", "C1307053#ent", "<e2>", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "show", "that", "the", "rigidity", "response", "through", "increased", "spreading", "and", "growth", "correlates", "with", "leading", "edge", "recruitment", "of", "C1442788#ent", "<e1>", ",", "but", "not", "endogenous", "C1307053#ent", "<e2>", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [24, 25]}}
{"token": ["C0023944#ent", "<e1>", "characterized", "by", "quadriplegia", ",", "C0028866#ent", "<e2>", "and", "mutism", "but", "with", "maintenance", "of", "consciousness", ",", "as", "well", "as", "vertical", "eye", "movements", "eyelid", "blinking"], "h": {"id": "C0023944", "name": "C0023944#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028866", "name": "C0028866#ent", "pos": [6, 7]}}
{"token": ["Pretreatment", "with", "albuterol", ",", "C0012694#ent", "<e1>", ",", "and", "a", "combination", "of", "albuterol", "and", "C0012694#ent", "<e1>", "30", "minutes", "before", "C1705691#ent", "<e1>", "exposure", "significantly", "diminished", "airway", "reactivity", "to", "C1705691#ent", "<e1>", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705691", "name": "C1705691#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "C0242422#ent", "<e1>", "phenotype", "of", "C0024408#ent", "<e2>", "SCA3", ")", "in", "three", "female", "sibs", "from", "one", "Taiwanese", "family", ",", "found", "in", "a", "genetic", "analysis", "60", "patients", "from", "49", "families", "with", "familial", "parkinsonism"], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0024408", "name": "C0024408#ent", "pos": [7, 8]}}
{"token": ["PCR", "amplification", "cDNAs", "of", "the", "housekeeping", "genes", "C3536868#ent", "<e1>", "GAPDH", ")", "and", "hypoxanthine", "phosphoribosyltransferase", "C1704831#ent", "<e2>", ")", "mRNAs", "was", "then", "performed", "."], "h": {"id": "C3536868", "name": "C3536868#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704831", "name": "C1704831#ent", "pos": [14, 15]}}
{"token": ["Another", "metabolite", "of", "C0055771#ent", "<e1>", ",", "3-bromocinnamic", "acid", "which", "may", "have", "some", "C0003286#ent", "<e2>", "can", "be", "analyzed", "simultaneously", "by", "buffering", "the", "mobile", "phase", "adding", "an", "ion-pairing", "reagent", "."], "h": {"id": "C0055771", "name": "C0055771#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [12, 13]}}
{"token": ["C0055771#ent", "<e1>", "is", "an", "experimental", "C0003286#ent", "<e2>", "currently", "in", "phase", "II", "testing", "."], "h": {"id": "C0055771", "name": "C0055771#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [5, 6]}}
{"token": ["After", "an", "intraventricular", "injection", "of", "C0021974#ent", "<e1>", ",", "activity", "of", "C1415275#ent", "<e2>", "brain", "was", "inhibited", "19", "%", "and", "the", "content", "of", "reduced", "glutathione", "was", "decreased", "20", "%", "."], "h": {"id": "C0021974", "name": "C0021974#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415275", "name": "C1415275#ent", "pos": [10, 11]}}
{"token": ["The", "influence", "of", "lithium", "heparin", "C0021974#ent", "<e1>", "the", "determination", "of", "C1415275#ent", "<e2>", "activity", "was", "investigated", "."], "h": {"id": "C0021974", "name": "C0021974#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415275", "name": "C1415275#ent", "pos": [10, 11]}}
{"token": ["In", "the", "present", "study", "the", "effect", "of", "renal", "function", "C1332656#ent", "<e1>", "concentrations", "was", "investigated", "in", "patients", "with", "various", "degrees", "of", "C1565662#ent", "<e2>", "in", "patients", "with", "chronic", "renal", "failure", "in", "CAPD", "patients", "."], "h": {"id": "C1332656", "name": "C1332656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [20, 21]}}
{"token": ["Signalling", "molecules", "activated", "downstream", "of", "gp130", "in", "ES", "cells", "STAT3", ",", "the", "protein", "tyrosine", "phosphatase", "C1706044#ent", "<e1>", ",", "and", "the", "C0169101#ent", "<e2>", "ERK1", "and", "ERK2", "."], "h": {"id": "C1706044", "name": "C1706044#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [20, 21]}}
{"token": ["Using", "this", "differentially", "expressed", "cDNA", "fragment", "C1418596#ent", "<e1>", "to", "screen", "a", "C0812235#ent", "<e2>", "cDNA", "library", "a", "near", "full-length", "cDNA", "for", "this", "gene", "was", "isolated", "."], "h": {"id": "C1418596", "name": "C1418596#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812235", "name": "C0812235#ent", "pos": [11, 12]}}
{"token": ["Amoebicidal", "drugs", "like", "enterovioform", "and", "chloroquine", "phosphate", "inhibited", "the", "C0027203#ent", "<e1>", "completely", ",", "while", "C0013973#ent", "<e2>", "showed", "marked", "inhibitory", "effect"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013973", "name": "C0013973#ent", "pos": [14, 15]}}
{"token": ["Substrate", "specificity", "indicated", "that", "the", "C0027203#ent", "<e1>", "was", "NAD+-specific", "and", "was", "able", "to", "catabolize", "readily", "various", "prostaglandins", ",", "with", "the", "exception", "of", "prostaglandin", "B", "thromboxane", "B.", "C0027203#ent", "<e1>", "was", "inhibited", "by", "sulfhydryl", "inhibitors", "C0013973#ent", "<e1>", "various", "fatty", "acids"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013973", "name": "C0013973#ent", "pos": [33, 34]}}
{"token": ["Cells", "expressing", "expanded", "repeats", "had", "reduced", "beta-catenin", "levels", "associated", "with", "parallel", "decrease", "in", "C1420699#ent", "<e1>", "compared", "with", "cells", "expressing", "C1883559#ent", "<e2>", "constructs", "."], "h": {"id": "C1420699", "name": "C1420699#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [19, 20]}}
{"token": ["Newly", "formed", "extracellular", "matrix", "stabilized", "by", "the", "C0027203#ent", "<e1>", ",", "tissue", "transglutaminase", "which", "we", "demonstrated", "to", "be", "overexpressed", "by", "C1854310#ent", "<e2>", "fibroblasts", "in", "vivo", "in", "vitro"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1854310", "name": "C1854310#ent", "pos": [19, 20]}}
{"token": ["The", "administration", "of", "d-myo-inositol", "1,4,5-tris-phosphate", "increased", "the", "expression", "of", "C1417703#ent", "<e1>", "activated", "T-cells", "and", "cardiac-restricted", "zinc", "finger", "transcription", "factor", "(", "C2700223#ent", "<e2>", ")", "."], "h": {"id": "C1417703", "name": "C1417703#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2700223", "name": "C2700223#ent", "pos": [20, 21]}}
{"token": ["In", "vitro", "experiments", "revealed", "that", "P-450j", "was", "severalfold", "more", "susceptible", "to", "inactivation", "by", "the", "C0010583#ent", "<e1>", "metabolite", "acrolein", "as", "compared", "with", "C0608437#ent", "<e2>"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [14, 15]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [21, 22]}}
{"token": ["In", "this", "chapter", ",", "we", "have", "tried", "to", "identify", "some", "of", "the", "variables", "related", "to", "the", "visual", "prognosis", "in", "C0235267#ent", "<e1>", "with", "presumed", "C0730362#ent", "<e2>"], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0730362", "name": "C0730362#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "CNK-602A", "(", "N-[(6-methyl-5-oxo-3-thiomorpholinyl", ")", "carbonyl]-L-histidyl-L-prolinamide", ")", ",", "a", "novel", "thyrotropin-releasing", "hormone", "related", "analog", "were", "investigated", "on", "absence-like", "seizure", "C0014549#ent", "<e1>", "the", "spontaneously", "C0014544#ent", "<e2>", "SER", ")", ",", "which", "is", "a", "genetically", "defined", "double-mutant", "."], "h": {"id": "C0014549", "name": "C0014549#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [25, 26]}}
{"token": ["Twenty-five", "participants", "identified", "as", "C0014549#ent", "<e1>", "sufferers", "and", "twenty-five", "participants", "without", "C0014544#ent", "<e2>", ",", "matched", "for", "age", ",", "sex", ",", "location", "and", "socio-economic", "status", "tested", "."], "h": {"id": "C0014549", "name": "C0014549#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [11, 12]}}
{"token": ["Cross-linking", "C1335285#ent", "<e1>", "potently", "reduced", "PTPase", "activity", "C3891563#ent", "<e2>", "+", "T", "cells", "restored", "their", "ability", "to", "proliferate", "in", "response", "to", "IL-4", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3891563", "name": "C3891563#ent", "pos": [7, 8]}}
{"token": ["Immunophenotyping", "of", "the", "neoplastic", "cells", "that", "they", "were", "positive", "for", "CD30", "(", "Ber-H2", ")", ",", "CD15", "(", "Leu-M1", ")", ",", "C1335285#ent", "<e1>", "(", "LCA", ")", ",", "and", "C3891563#ent", "<e2>", "(", "UCHL-1", ")", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3891563", "name": "C3891563#ent", "pos": [27, 28]}}
{"token": ["We", "have", "reported", "previously", "that", "cross-linking", "of", "C1335285#ent", "<e1>", "and", "the", "C3891563#ent", "<e2>", "isoform", "on", "IL-2-activated", "NK", "cells", "the", "NK", "cell", "line", "results", "in", "the", "stimulation", "of", "IFN-gamma", "production", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3891563", "name": "C3891563#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "we", "show", "that", "ScLPLAT", "differs", "from", "the", "specific", "C0126485#ent", "<e1>", "is", "encoded", "by", "C1825952#ent", "<e2>", "in", "that", "it", "can", "not", "efficiently", "use", "lysophosphatidic", "acid", "by", "acylation", "of", "glycerol-3-phosphate", "in", "vitro"], "h": {"id": "C0126485", "name": "C0126485#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1825952", "name": "C1825952#ent", "pos": [15, 16]}}
{"token": ["The", "possible", "formation", "mechanism", "of", "the", "NaYF4", "crystals", "and", "the", "role", "of", "C0795671#ent", "<e1>", "acts", "as", "a", "C3537172#ent", "<e2>", "shape", "modifier", "discussed", "in", "detail", "."], "h": {"id": "C0795671", "name": "C0795671#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3537172", "name": "C3537172#ent", "pos": [17, 18]}}
{"token": ["We", "also", "found", "that", "anemones", "show", "a", "trend", "of", "increasing", "contents", "of", "methylamines", "(", "C0026454#ent", "<e1>", ",", "betaine", ")", "and", "C0074214#ent", "<e2>", "with", "increasing", "depth", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0074214", "name": "C0074214#ent", "pos": [20, 21]}}
{"token": ["The", "late", "prognosis", "repair", "of", "an", "abdominal", "aortic", "aneurysm", "C1364818#ent", "<e1>", ")", "may", "be", "affected", "by", "C0003850#ent", "<e2>", ",", "which", "involves", "various", "organs", "including", "the", "aorta", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [16, 17]}}
{"token": ["Abdominal", "aortic", "aneurysms", "C1364818#ent", "<e1>", ")", "represent", "a", "potentially", "lethal", "disorder", "associated", "with", "aging", "and", "C0003850#ent", "<e2>", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [15, 16]}}
{"token": ["The", "CYP3A5", "gene", "C1413882#ent", "<e1>", ")", "encodes", "the", "C0535996#ent", "<e2>", "which", "catalyzes", "the", "6beta-hydroxylation", "of", "testosterone", "."], "h": {"id": "C1413882", "name": "C1413882#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0535996", "name": "C0535996#ent", "pos": [8, 9]}}
{"token": ["C1868678#ent", "<e1>", "maps", "in", "the", "vicinity", "of", "C0597336#ent", "<e2>", "affect", "seed", "row", "number", "spikelet", "density", "and", "plant", "height"], "h": {"id": "C1868678", "name": "C1868678#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597336", "name": "C0597336#ent", "pos": [7, 8]}}
{"token": ["These", "data", "suggest", "that", "macrophages", "and", "neutrophils", "infiltrating", "into", "the", "liver", "sinusoids", "around", "the", "bile", "duct", "a", "pivotal", "role", "in", "C1333522#ent", "<e1>", "expression", ",", "leading", "to", "coagulopathy", "in", "the", "acute", "phase", "C0008311#ent", "<e2>", "rabbits", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [31, 32]}}
{"token": ["C0537026#ent", "<e1>", "conjugates", "bilirubin", ",", "and", "mutations", "of", "the", "C0079429#ent", "<e2>", "cause", "hereditary", "unconjugated", "hyperbilirubinemias", "Crigler-Najjar", "syndrome", "Gilbert's", "syndrome", "."], "h": {"id": "C0537026", "name": "C0537026#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["The", "phenobarbital-responsive", "enhancer", "module", "(", "PBREM", ")", "of", "the", "C0537026#ent", "<e1>", "promoter", "region", "been", "reportedly", "associated", "with", "transcriptional", "activity", "the", "C0079429#ent", "<e2>", "."], "h": {"id": "C0537026", "name": "C0537026#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [20, 21]}}
{"token": ["C2936275#ent", "<e1>", "ARBs", ")", "are", "regarded", "as", "first-line", "treatments", "C0011854#ent", "<e2>", "hypertension", "."], "h": {"id": "C2936275", "name": "C2936275#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [9, 10]}}
{"token": ["Sequence", "analysis", "that", "C1421231#ent", "<e1>", "only", "83", "%", "identical", "to", "the", "two", "C3539817#ent", "<e2>", "expressed", "in", "amoebae", "."], "h": {"id": "C1421231", "name": "C1421231#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539817", "name": "C3539817#ent", "pos": [12, 13]}}
{"token": ["The", "paper", "deals", "with", "the", "study", "into", "the", "benefits", "of", "C0032912#ent", "<e1>", "and", "trasicor", "used", "in", "C0020538#ent", "<e2>"], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["There", "were", "26", "episodes", "of", "C0037199#ent", "<e1>", ",", "27", "episodes", "of", "otitis", "media", "20", "episodes", "of", "C0749591#ent", "<e2>", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0749591", "name": "C0749591#ent", "pos": [16, 17]}}
{"token": ["Chromatographic", "and", "electrophoretic", "properties", "as", "well", "as", "the", "chemical", "reaction", "the", "product", "with", "specific", "reagents", "suggest", "that", "the", "compound", "consists", "of", "an", "C0021236#ent", "<e1>", "part", "and", "an", "C2917660#ent", "<e2>", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [27, 28]}}
{"token": ["The", "kinetics", "of", "isoniazid", "and", "C1413693#ent", "<e1>", "oxidation", "by", "horseradish", "peroxidase", "C3889156#ent", "<e2>", ")", "in", "the", "presence", "of", "both", "compounds", "suggested", "C1413693#ent", "<e1>", "was", "acting", "as", "an", "electron", "transfer", "between", "C3889156#ent", "<e2>", "and", "isoniazid", "."], "h": {"id": "C1413693", "name": "C1413693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889156", "name": "C3889156#ent", "pos": [11, 12]}}
{"token": ["Mild", "forms", "C0242422#ent", "<e1>", "were", "observed", "in", "3", "%", "of", "patients", "with", "C0041296#ent", "<e2>", ",", "vascular", "dementia", "detectable", "rarely", "0.2", "%", ")", ",", "strokes", "run", "without", "severe", "overall", "cerebral", "symptoms"], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [12, 13]}}
{"token": ["11", ")", "The", "induction", "of", "enzymes", "and", "of", "C2984537#ent", "<e1>", "RXR", "alpha", "are", "increased", "by", "C0011777#ent", "<e2>", "and", "counteracted", "by", "insulin", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "C0055695#ent", "<e1>", "(", "a", "novel", "8-ethyl-7,8-dihydro-1,3,5-trimethyl-1H-imidazo[1,2-c]pyrazolo[3,4-", "e]pyrimidine", "compound", "exhibiting", "a", "favorable", "C0040615#ent", "<e2>", "animal", "tests", "on", "neurochemical", "parameters", "related", "to", "biogenic", "amine", "have", "been", "studied", "in", "rat", "brain", "."], "h": {"id": "C0055695", "name": "C0055695#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [14, 15]}}
{"token": ["It", "has", "been", "reported", "that", "C0053526#ent", "<e1>", "(", "MCC", ")", ",", "a", "C0242948#ent", "<e2>", "binds", "to", "central", "nicotinic", "receptors", "causes", "an", "increase", "of", "acetylcholine", "(", "ACh", ")", "release", "from", "certain", "central", "cholinergic", "nerve", "terminals"], "h": {"id": "C0053526", "name": "C0053526#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242948", "name": "C0242948#ent", "pos": [12, 13]}}
{"token": ["The", "stimulants", "and", "C0007422#ent", "<e1>", "are", "the", "most", "commonly", "C0282090#ent", "<e2>", "have", "the", "potential", "for", "causing", "the", "most", "long-term", "damage", "."], "h": {"id": "C0007422", "name": "C0007422#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0282090", "name": "C0282090#ent", "pos": [9, 10]}}
{"token": ["Skeletal", "muscle", "involvement", "is", "a", "common", "feature", "in", "C1290138#ent", "<e1>", "SSc", ")", "because", "C0151786#ent", "<e2>", "found", "in", "up", "to", "90", "%", "SSc", "patients", "when", "systematically", "assessed", "."], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0151786", "name": "C0151786#ent", "pos": [13, 14]}}
{"token": ["The", "urinary", "excretion", "C0876231#ent", "<e1>", "also", "increased", "in", "all", "patients", "with", "C0268483#ent", "<e2>", "to", "patients", "with", "neonatal", "transient", "tyrosinemia", "and", "to", "normal", "individuals", "."], "h": {"id": "C0876231", "name": "C0876231#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268483", "name": "C0268483#ent", "pos": [11, 12]}}
{"token": ["This", "suggests", "that", "C1413666#ent", "<e1>", "accounts", "for", "the", "antifibrinolytic", "effect", "accompanies", "prothrombin", "activation", "that", "activated", "C1418943#ent", "<e2>", "profibrinolytic", "by", "attenuating", "C1413666#ent", "<e1>", "activation", "."], "h": {"id": "C1413666", "name": "C1413666#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [15, 16]}}
{"token": ["Northern", "blot", "analysis", "that", "BPA", "transiently", "induced", "C1705265#ent", "<e1>", "mRNA", "expression", ",", "and", "protein", "kinase", "inhibitor", "H-89", "and", "PD98059", "strongly", "inhibited", "the", "induction", "of", "BPA-mediated", "C1705265#ent", "<e1>", "gene", "expression", "in", "mouse", "Leydig", "tumor", "cell", "line", "C1825746#ent", "<e1>", "."], "h": {"id": "C1705265", "name": "C1705265#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1825746", "name": "C1825746#ent", "pos": [35, 36]}}
{"token": ["Differences", "in", "the", "time", "dependence", "Stat5", "C0812382#ent", "<e1>", "activation", "by", "the", "three", "different", "ligands", ",", "C3539616#ent", "<e2>", ",", "Prl", "and", "PL", ",", "were", "found", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [15, 16]}}
{"token": ["Gel", "electrophoretic", "mobility", "shift", "assay", "GEMSA", ")", "of", "nuclear", "extract", "that", "both", "STAT5A", "and", "STAT5B", "obtained", "C0812382#ent", "<e1>", "capacity", "after", "C3539616#ent", "<e2>", "stimulation", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [20, 21]}}
{"token": ["Expression", "of", "C0694872#ent", "<e1>", "and", "collagen", "type", "IV", "found", "in", "healthy", "and", "C0003864#ent", "<e2>", "synovial", "tissue"], "h": {"id": "C0694872", "name": "C0694872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [12, 13]}}
{"token": ["Each", "occurrence", "of", "C0700200#ent", "<e1>", "was", "associated", "a", "low", "PNS", "indicator", "as", "well", "as", "C2827389#ent", "<e2>", "<", "2.50", "(", "beta", ">", "or", "=", "1.80", ")", "."], "h": {"id": "C0700200", "name": "C0700200#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2827389", "name": "C2827389#ent", "pos": [14, 15]}}
{"token": ["14", "-", "3", "-", "3", "and", "Hsp90", "proteins", "blocked", "both", "the", "tyrosine", "dephosphorylation", "inactivation", "of", "C1706586#ent", "<e1>", ",", "suggesting", "that", "C1706586#ent", "<e1>", "activity", "is", "C0085536#ent", "<e1>", "dependent", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [24, 25]}}
{"token": ["Typical", "C0002962#ent", "<e1>", "easy", "to", "recognize", ",", "but", "C0542052#ent", "<e2>", "present", "with", "nonspecific", "chest", "discomfort"], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0542052", "name": "C0542052#ent", "pos": [8, 9]}}
{"token": ["With", "regard", "to", "coronary", "circulation", "arterial", "hypertension", "an", "important", "risk", "factor", "coronary", "artery", "disease", "but", "even", "in", "the", "absence", "of", "coronary", "artery", "disease", "hypertensive", "patients", "frequently", "have", "C0002962#ent", "<e1>", "reveal", "electrocardiographic", "abnormalities", "of", "myocardial", "ischaemia", "to", "C0542052#ent", "<e2>"], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0542052", "name": "C0542052#ent", "pos": [36, 37]}}
{"token": ["Postoperative", "complications", "cited", "included", "mechanical", "problems", "the", "lens", "and", "C1256254#ent", "<e1>", ",", "cystoid", "macular", "edema", "glaucoma", ",", "and", "C0014236#ent", "<e2>", "."], "h": {"id": "C1256254", "name": "C1256254#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014236", "name": "C0014236#ent", "pos": [18, 19]}}
{"token": ["Idiopathic", "neonatal", "hepatitis", "the", "uncommon", "C1848862#ent", "<e1>", "of", "prolonged", "C0022354#ent", "<e2>", "associated", "with", "giant", "cell", "transformation", "the", "liver", "and", "patent", "bile", "ducts"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [9, 10]}}
{"token": ["The", "recognition", "of", "this", "C1848862#ent", "<e1>", "in", "a", "young", "child", "C0022354#ent", "<e2>", "obviate", "the", "need", "for", "a", "diagnostic", "laparotomy"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [10, 11]}}
{"token": ["Immunofluorescent", "deposits", "the", "dermal-epidermal", "junction", "DEJ", ")", "of", "the", "skin", "(", "C0409974#ent", "<e1>", "LBT", ")", "were", "evaluated", "in", "134", "patients", "with", "various", "C0009782#ent", "<e2>"], "h": {"id": "C0409974", "name": "C0409974#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [22, 23]}}
{"token": ["To", "examine", "the", "effect", "of", "C1565860#ent", "<e1>", "inhibition", "on", "CNV", ",", "etodolac", ",", "a", "C3536840#ent", "<e2>", "a", "high", "C1565860#ent", "<e1>", "selectivity", ",", "was", "tested", "on", "murine", "CNV", "model", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536840", "name": "C3536840#ent", "pos": [14, 15]}}
{"token": ["Small", "interfering", "RNA-mediated", "knockdown", "of", "C1428707#ent", "<e1>", "impairs", "both", "the", "amino", "acid-", "and", "insulin-stimulated", "phosphorylation", "of", "C2984182#ent", "<e2>", "and", "the", "phosphorylation", "of", "S6", "."], "h": {"id": "C1428707", "name": "C1428707#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2984182", "name": "C2984182#ent", "pos": [16, 17]}}
{"token": ["To", "further", "investigate", "the", "molecular", "mechanisms", "in", "these", "adaptation", "processes", "to", "C0020456#ent", "<e1>", ",", "we", "have", "studied", "the", "regulation", "of", "C0017337#ent", "<e2>", "encoding", "key", "glycolytic", "enzymes", "in", "the", "glucose-responsive", "beta-cell", "line", "INS-1", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["Despite", "the", "resemblance", "of", "their", "reactions", ",", "five", "classes", "of", "C0796250#ent", "<e1>", "and", "NPs", "exist", ",", "where", "anthranilate", "PRT", "C1417810#ent", "<e2>", ")", "constitutes", "the", "only", "evolutionary", "link", "between", "synthesis", "and", "degradation", "processes", "."], "h": {"id": "C0796250", "name": "C0796250#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417810", "name": "C1417810#ent", "pos": [19, 20]}}
{"token": ["Carbon", "dioxide", "C0000979#ent", "<e1>", ",", "lactate", ",", "ethanol", ",", "and", "C0045347#ent", "<e2>", "were", "detected", "in", "the", "produced", "fluids", "of", "the", "inoculated", "wells", "."], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0045347", "name": "C0045347#ent", "pos": [10, 11]}}
{"token": ["The", "main", "intermediate", "of", "the", "oxidative", "pathway", "pyruvate", ",", "the", "further", "utilization", "of", "which", "produces", "CO2", ",", "H2", ",", "C0000979#ent", "<e1>", ",", "butyrate", ",", "ethanol", ",", "butanol", "and", "C0045347#ent", "<e2>", "."], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0045347", "name": "C0045347#ent", "pos": [28, 29]}}
{"token": ["A", "60-year-old", "man", "had", "been", "administered", "diphenylhydantoin", "(", "C0851183#ent", "<e1>", ")", "for", "prevention", "of", "convulsive", "seizures", "clipping", "of", "an", "C0751003#ent", "<e2>", "of", "the", "middle", "cerebral", "artery"], "h": {"id": "C0851183", "name": "C0851183#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [19, 20]}}
{"token": ["C1161438#ent", "<e1>", "(", "CP", ")", "facilitates", "the", "development", "of", "C0004364#ent", "<e2>", "of", "a", "selective", "depletion", "of", "suppressor", "T", "cells"], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [9, 10]}}
{"token": ["Fructose-1,6-bisphosphatase", "(", "FBPase", ")", "(", "C3889472#ent", "<e1>", "catalyzes", "the", "splitting", "of", "C1414544#ent", "<e2>", "into", "fructose", "6-phosphate", "inorganic", "phosphate"], "h": {"id": "C3889472", "name": "C3889472#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414544", "name": "C1414544#ent", "pos": [11, 12]}}
{"token": ["We", "report", "for", "the", "first", "time", "a", "4-year-old", "boy", "with", "C0751908#ent", "<e1>", "serological", "results", "compatible", "with", "C0001486#ent", "<e2>"], "h": {"id": "C0751908", "name": "C0751908#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [16, 17]}}
{"token": ["Of", "the", "32", "patients", "who", "had", "no", "history", "prior", "C0036572#ent", "<e1>", ",", "only", "1", "had", "a", "seizure", "during", "C0009010#ent", "<e2>", "treatment", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009010", "name": "C0009010#ent", "pos": [18, 19]}}
{"token": ["Although", "uncommon", ",", "the", "occurrence", "of", "C0036572#ent", "<e1>", "and", "elevated", "aminotransferase", "values", "are", "potentially", "serious", "side", "effects", "C0009010#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009010", "name": "C0009010#ent", "pos": [17, 18]}}
{"token": ["In", "13", "patients", "with", "C0020538#ent", "<e1>", "drug", "exerted", "marked", "C0003364#ent", "<e2>"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [9, 10]}}
{"token": ["C0017574#ent", "<e1>", "also", "occur", "as", "gingival", "manifestations", "C0018939#ent", "<e2>", "the", "most", "relevant", "of", "these", "being", "lichen", "planus", "pemphigoid", ",", "pemphigus", "vulgaris", "erythema", "multiforme", "and", "lupus", "erythematosus"], "h": {"id": "C0017574", "name": "C0017574#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [7, 8]}}
{"token": ["These", "results", "indicated", "that", "activation", "of", "JAK1", ",", "JAK2", "and", "C1367307#ent", "<e1>", "is", "necessary", "for", "leptin-induced", "transactivation", "of", "C1417815#ent", "<e2>", "the", "leptin-response", "element", "these", "neural", "cells"], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [18, 19]}}
{"token": ["C0022322#ent", "<e1>", ",", "a", "broad", "spectrum", "C0003404#ent", "<e2>", "interrupted", "the", "uptake", "of", "Onchocerca", "volvulus", "microfilariae", "by", "Simulium", "ochraceum", "a", "group", "of", "human", "volunteers", "given", "multiple", "oral", "treatments", "200", "micrograms/kg", "body", "weight"], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003404", "name": "C0003404#ent", "pos": [6, 7]}}
{"token": ["C0022322#ent", "<e1>", "is", "a", "C0003404#ent", "<e2>", "commonly", "used", "in", "humans", "and", "livestock", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003404", "name": "C0003404#ent", "pos": [4, 5]}}
{"token": ["C0022322#ent", "<e1>", ",", "an", "oral", "C0003404#ent", "<e2>", "has", "been", "shown", "to", "be", "an", "effective", "scabicide", "and", "could", "be", "a", "useful", "substitute", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003404", "name": "C0003404#ent", "pos": [5, 6]}}
{"token": ["Here", "we", "investigated", "the", "influence", "of", "C0288171#ent", "<e1>", "on", "the", "expression", "of", "the", "C1334128#ent", "<e2>", "ILK", ")", "and", "its", "relationship", "with", "epithelial-mesenchymal", "transition", "EMT", ")", "in", "mice", "with", "unilateral", "ureteral", "obstruction", "UUO", ")", "."], "h": {"id": "C0288171", "name": "C0288171#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334128", "name": "C1334128#ent", "pos": [13, 14]}}
{"token": ["Second", ",", "the", "effect", "of", "C2930042#ent", "<e1>", "the", "relative", "bioavailability", "of", "C0085154#ent", "<e2>", ",", "famotidine", ",", "cimetidine", "and", "ranitidine", "was", "evaluated", "in", "healthy", "volunteers"], "h": {"id": "C2930042", "name": "C2930042#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085154", "name": "C0085154#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "release", "of", "C2985420#ent", "<e1>", "from", "the", "cell", "surface", "mediated", "by", "a", "C0127082#ent", "<e2>", "probably", "regulates", "B7-H3R/B7-H3", "interactions", "in", "vivo"], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [15, 16]}}
{"token": ["Respondents", "viewed", "HIV/AIDS", "and", "medication", "in", "terms", "of", "other", "C0679247#ent", "<e1>", "and", "drugs", ",", "including", "C0009443#ent", "<e2>", ",", "cancer", ",", "and", "street", "drugs"], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "we", "used", "integrative", "genetic", ",", "pharmacological", "and", "electrophysiological", "approaches", "to", "demonstrate", "that", "AMPA", "C1415288#ent", "<e1>", ",", "but", "not", "C1704949#ent", "<e2>", ",", "subunit", "is", "critical", "for", "cingulate", "LTD", "."], "h": {"id": "C1415288", "name": "C1415288#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [20, 21]}}
{"token": ["Exposure", "of", "cells", "to", "C0085752#ent", "<e1>", "also", "caused", "enhancement", "of", "IPN-stimulated", "activity", "of", "C1382029#ent", "<e2>", "exposure", "to", "nitrogen", "mustard", "inhibited", "the", "enzyme", "stimulation", "by", "IPN", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [13, 14]}}
{"token": ["C0085752#ent", "<e1>", "also", "reduced", "the", "stimulatory", "effect", "of", "PTH", "on", "C1382029#ent", "<e2>", "activity", "in", "a", "crude", "plasma", "membrane", "preparation", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [10, 11]}}
{"token": ["Genetic", "analysis", "new", "C1842577#ent", "<e1>", "Hirschsprung's", "disease", "patients", "may", "identify", "the", "candidate", "C1417679#ent", "<e2>", "."], "h": {"id": "C1842577", "name": "C1842577#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Our", "studies", "provide", "further", "evidence", "that", "the", "transforming", "potential", "of", "these", "C0029016#ent", "<e1>", "involve", "activities", "beyond", "their", "inactivation", "of", "C1705526#ent", "<e2>", "and", "pRB", "functions", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [19, 20]}}
{"token": ["C0029016#ent", "<e1>", "HCCR-1", "functions", "as", "a", "negative", "regulator", "of", "the", "C1705526#ent", "<e2>", "and", "contributes", "to", "tumorigenesis", "of", "various", "human", "tissues", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [10, 11]}}
{"token": ["The", "total", "C0001962#ent", "<e1>", "extract", "of", "Citrus", "junos", "a", "significant", "inhibitory", "effect", "on", "C0001044#ent", "<e2>", "in", "vitro"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001044", "name": "C0001044#ent", "pos": [13, 14]}}
{"token": ["A", "28-year-old", "woman", "who", "was", "treated", "for", "C0700345#ent", "<e1>", "Gyno-Daktarin", "vaginal", "capsules", "(", "C0086620#ent", "<e2>", "became", "pregnant", "because", "a", "condom", "used", "during", "intercourse", "had", "ruptured", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0086620", "name": "C0086620#ent", "pos": [13, 14]}}
{"token": ["The", "development", "of", "this", "C0154251#ent", "<e1>", "a", "multitude", "of", "C0025517#ent", "<e2>", "deficient", "clearance", "of", "triglycerides", "and/or", "their", "increased", "output", "aggravated", "by", "obesity", ",", "diabetes", ",", "alcohol", "intake", "or", "use", "of", "some", "hormones", "."], "h": {"id": "C0154251", "name": "C0154251#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}}
{"token": ["C0010762#ent", "<e1>", "often", "a", "challenging", "C1416596#ent", "<e2>", ",", "owing", "to", "the", "rather", "low", "sequence", "identity", "between", "target", "and", "template", "proteins"], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [5, 6]}}
{"token": ["Compared", "with", "the", "C1882525#ent", "<e1>", "transfectants", ",", "an", "inverse", "expression", "pattern", "of", "activin", "betaE", ",", "Id2", "and", "C3543405#ent", "<e2>", "was", "shown", "in", "the", "immortalized", "nasopharyngeal", "epithelial", "cells", "treated", "with", "siRNA", "against", "C1882525#ent", "<e1>", "."], "h": {"id": "C3543405", "name": "C3543405#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1882525", "name": "C1882525#ent", "pos": [3, 4]}}
{"token": ["The", "results", "of", "the", "logistic", "regression", "analysis", "that", "age", "and", "C2711227#ent", "<e1>", "significant", "predictors", "of", "C0947622#ent", "<e2>"], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [15, 16]}}
{"token": ["Results", "of", "this", "study", "suggest", "that", "in", "C0018802#ent", "<e1>", "patients", ",", "20", "mg", "C0016860#ent", "<e2>", "per", "day", "has", "significant", "diuretic", "and", "natriuretic", "properties"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [13, 14]}}
{"token": ["There", "were", "four", "exacerbations", "of", "C0018802#ent", "<e1>", "ibopamine", "treatment", "and", "none", "during", "C0016860#ent", "<e2>", "treatment", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [12, 13]}}
{"token": ["An", "extraordinarily", "large", "number", "of", "C0035064#ent", "<e1>", "alter", "the", "level", "or", "activity", "of", "the", "C1706481#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706481", "name": "C1706481#ent", "pos": [14, 15]}}
{"token": ["Since", "human", "C1427125#ent", "<e1>", "was", "found", "to", "cleave", "the", "carboxyl", "terminus", "C1421946#ent", "<e2>", "in", "vitro", "we", "hypothesized", "that", "this", "exposes", "its", "carboxyl-terminal", "Gly(120", ")", "."], "h": {"id": "C1427125", "name": "C1427125#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421946", "name": "C1421946#ent", "pos": [11, 12]}}
{"token": ["Evidence", "is", "provided", "that", "the", "genes", "for", "C1537987#ent", "<e1>", "are", "encoded", "by", "nuclear", "DNA", "and", "the", "predicted", "C1305923#ent", "<e2>", "exhibit", "diminished", "physical", "constraints", "import", "as", "compared", "with", "mitochondrial-DNA", "encoded", "homologs", "."], "h": {"id": "C1537987", "name": "C1537987#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [17, 18]}}
{"token": ["Other", "agents", "known", "to", "modulate", "the", "induction", "of", "C1422630#ent", "<e1>", "by", "TPA", "(", "C0016299#ent", "<e2>", "tosyl-L-lysylchloromethane", ",", "and", "local", "anesthetics", "do", "not", "act", "differentially", "on", "UV", "induction", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016299", "name": "C0016299#ent", "pos": [13, 14]}}
{"token": ["The", "concurrent", "use", "of", "both", "aprotinin", "and", "C0000608#ent", "<e1>", "may", "induce", "a", "prothrombotic", "or", "C0003280#ent", "<e2>", "determined", "by", "histological", "assessment"], "h": {"id": "C0000608", "name": "C0000608#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [14, 15]}}
{"token": ["Cotransfection", "of", "C1709313#ent", "<e1>", "in", "GH(3", ")", "cells", "completely", "blocked", "C1421143#ent", "<e2>", "stimulation", "of", "the", "TSH", "subunit", "genes", ",", "suggesting", "that", "CBP", "is", "a", "key", "factor", "for", "C1421143#ent", "<e2>", "signaling", "in", "the", "pituitary", "."], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [10, 11]}}
{"token": ["Our", "in", "vitro", "results", "indicate", "that", "PrP(106", "-", "126", ")", "peptide", "induces", "tyrosine", "phosphorylation", "C1413898#ent", "<e1>", "by", "activated", "members", "the", "Src", "family", "C0033681#ent", "<e2>", "SFK", ")", ",", "which", "implies", "further", "C1413898#ent", "<e1>", "degradation", "."], "h": {"id": "C1413898", "name": "C1413898#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [22, 23]}}
{"token": ["We", "confirmed", "that", "C1335207#ent", "<e1>", "synthase", "is", "a", "dual", "function", "catalyzing", "the", "reduction", "of", "C0033551#ent", "<e2>", "and", "PGD2", "on", "a", "single", "enzyme", "and", "that", "it", "has", "one", "binding", "site", "NADPH", "."], "h": {"id": "C1335207", "name": "C1335207#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [14, 15]}}
{"token": ["The", "combination", "of", "chronic", "motor", "vocal", "tics", "C0040517#ent", "<e1>", "may", "in", "some", "children", "be", "associated", "with", "and", "behavioral", "disorders", "C0037317#ent", "<e2>", "headaches", ",", "and", "school", "difficulties", "e.g.", ",", "attention", "deficit", "disorder", "."], "h": {"id": "C0040517", "name": "C0040517#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0037317", "name": "C0037317#ent", "pos": [19, 20]}}
{"token": ["The", "fact", "that", "Gilles", "de", "la", "C0040517#ent", "<e1>", "frequently", "associated", "with", "migraine", ",", "C0037317#ent", "<e2>", "attentional", "or", "compulsive", "deficits", ",", "does", "not", "orient", "towards", "a", "specific", "cause", "."], "h": {"id": "C0040517", "name": "C0040517#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0037317", "name": "C0037317#ent", "pos": [13, 14]}}
{"token": ["uPA-activated-MMP-9", "efficiently", "degraded", "fibronectin", "and", "blocked", "by", "uPA", "inhibitor", "C0754251#ent", "<e1>", "and", "recombinant", "tissue", "of", "C0127082#ent", "<e2>", "(", "TIMP-1", ")", "."], "h": {"id": "C0754251", "name": "C0754251#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [15, 16]}}
{"token": ["Presentation", "suggested", "an", "C0267797#ent", "<e1>", "was", "complicated", "by", "C0018802#ent", "<e2>"], "h": {"id": "C0267797", "name": "C0267797#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}}
{"token": ["At", "steady", "state", "the", "H+/e-", "ratio", "for", "the", "C0242417#ent", "<e1>", "was", "specifically", "depressed", "by", "the", "C0021699#ent", "<e2>"], "h": {"id": "C0242417", "name": "C0242417#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [15, 16]}}
{"token": ["At", "variance", "with", "previous", "reports", ",", "C1524095#ent", "<e1>", "induced", "rapid", "and", "transient", "tyrosine", "phosphorylation", "C0136864#ent", "<e2>", "in", "myeloid", "FDC-P1", "cells", "and", "this", "activation", "required", "the", "activity", "of", "the", "PI3-kinase", "pathway", "."], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0136864", "name": "C0136864#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "the", "effects", "of", "ischemic", "preconditioning", "IP", ")", "on", "reperfusion", "arrhythmias", "C0011860#ent", "<e1>", "rats", "as", "well", "as", "the", "effects", "of", "insulin", "sensitizer", "C0872972#ent", "<e2>", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0872972", "name": "C0872972#ent", "pos": [23, 24]}}
{"token": ["The", "C1420613#ent", "<e1>", "binding", "site", "be", "bound", "by", "and", "respond", "to", "C3640152#ent", "<e2>"], "h": {"id": "C1420613", "name": "C1420613#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3640152", "name": "C3640152#ent", "pos": [11, 12]}}
{"token": ["No", "evidence", "shows", "that", "it", "is", "beneficial", "to", "treat", "C0015967#ent", "<e1>", "children", "with", "C0000970#ent", "<e2>", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [13, 14]}}
{"token": ["Home", "treatment", "C0015967#ent", "<e1>", "episodes", "was", "based", "on", "C0000970#ent", "<e2>", "or", "aspirin", "(", "84", "%", ")", ",", "chloroquine", "(", "13", "%", ")", "and", "cotrimoxazole", "(", "2.9", "%", ")", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [8, 9]}}
{"token": ["The", "pattern", "of", "loss", "of", "at", "loci", "D9S162", "and", "D9S171", "within", "the", "region", "of", "common", "loss", "on", "C2736876#ent", "<e1>", "encompasses", "the", "tumor", "suppressor", "gene", "enabled", "the", "distinction", "of", "four", "C1516876#ent", "<e2>", "different", "tumor", "cell", "populations", "."], "h": {"id": "C2736876", "name": "C2736876#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [29, 30]}}
{"token": ["We", "evaluated", "whether", "patients", "with", "coronary", "heart", "disease", "severe", "C0020443#ent", "<e1>", "showing", "insufficient", "LDL", "(", "low-density", "lipoprotein)", "cholesterol", "reduction", "despite", "combined", "therapy", "C0074554#ent", "<e2>", "and", "regular", "LDL", "apheresis", "will", "benefit", "from", "atorvastatin", "therapy"], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0074554", "name": "C0074554#ent", "pos": [22, 23]}}
{"token": ["We", "explored", "whether", "C1705280#ent", "<e1>", "participates", "in", "NADPH", "oxidase", "activation", "by", "formyl-methionine-leucine-phenylalanine", "(", "C1333574#ent", "<e2>", ")", "and", "whether", "this", "involves", "PLD", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [13, 14]}}
{"token": ["The", "solution", "structure", "a", "recombinant", "C0032143#ent", "<e1>", "complexed", "with", "the", "C0000608#ent", "<e2>", "6-AHA", ")", "was", "determined", "via", "1H", "nuclear", "magnetic", "resonance", "spectroscopy", "dynamical", "simulated", "annealing", "calculations", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000608", "name": "C0000608#ent", "pos": [10, 11]}}
{"token": ["The", "sera", "of", "63", "patients", "with", "C0398738#ent", "<e1>", "including", "27", "adults", "and", "36", "with", "chronic", "bullous", "dermatosis", "of", "childhood", "C0079083#ent", "<e2>", ")", "were", "examined", "."], "h": {"id": "C0398738", "name": "C0398738#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [19, 20]}}
{"token": ["Carvedilol", ",", "C0724633#ent", "<e1>", "bisprolol", "have", "evidence", "supporting", "their", "use", "in", "C0018801#ent", "<e2>", "other", "beta", "blockers", "lack", "evidence", "supporting", "their", "use", "or", "have", "not", "been", "shown", "to", "be", "useful", "in", "C0018801#ent", "<e2>"], "h": {"id": "C0724633", "name": "C0724633#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}}
{"token": ["The", "MERIT-HF", "trial", "demonstrated", "improved", "survival", "and", "fewer", "hospitalizations", "for", "worsening", "C0018801#ent", "<e1>", "extended-release", "(", "ER", ")", "C0724633#ent", "<e2>", "patients", "with", "C0018801#ent", "<e1>"], "h": {"id": "C0724633", "name": "C0724633#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}}
{"token": ["The", "inherited", "cancer", "syndrome", "multiple", "endocrine", "neoplasia", "type", "2", "C1538738#ent", "<e1>", ")", ",", "associated", "with", "mutations", "in", "C1704885#ent", "<e2>", ",", "is", "characterized", "by", "medullary", "thyroid", "carcinoma"], "h": {"id": "C1538738", "name": "C1538738#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704885", "name": "C1704885#ent", "pos": [17, 18]}}
{"token": ["Other", "important", "common", "C0029896#ent", "<e1>", "are", "likely", "to", "include", "osteoporosis", ",", "osteoarthritis", "and", "C0917996#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0917996", "name": "C0917996#ent", "pos": [13, 14]}}
{"token": ["Until", "now", ",", "a", "C1848862#ent", "<e1>", "characterized", "by", "TS", ",", "ACC", "and", "C0238111#ent", "<e2>", "LGS", ")", "has", "not", "been", "described", "in", "the", "literature", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [12, 13]}}
{"token": ["A", "number", "of", "regions", "present", "in", "both", "C0030933#ent", "<e1>", "and", "EF-G", "from", "Escherichia", "coli", "also", "found", "in", "C0059036#ent", "<e2>", "Artemia", "."], "h": {"id": "C0030933", "name": "C0030933#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [17, 18]}}
{"token": ["In", "large", "measure", ",", "it", "would", "appear", "that", "the", "overall", "structure", "probably", "been", "maintained", "given", "the", "33", "%", "identity", "and", "56", "%", "similarity", "of", "Escherichia", "coli", "C0030933#ent", "<e1>", "with", "human", "C0059036#ent", "<e2>"], "h": {"id": "C0030933", "name": "C0030933#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [30, 31]}}
{"token": ["These", "data", "define", "and", "localize", "a", "set", "of", "discrete", "C0678933#ent", "<e1>", "the", "Tse", "loci", ",", "that", "negatively", "regulate", "C1420131#ent", "<e2>", "in", "trans", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420131", "name": "C1420131#ent", "pos": [18, 19]}}
{"token": ["When", "IVDMD", "was", "partitioned", "into", "in", "vitro", "digestible", "C0057753#ent", "<e1>", "(", "IVdNDS", ")", "and", "in", "vitro", "digestible", "C1705020#ent", "<e2>", ",", "the", "IVdNDS", "of", "whole", "was", "not", "uniform", "or", "completely", "fermented", "."], "h": {"id": "C0057753", "name": "C0057753#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705020", "name": "C1705020#ent", "pos": [17, 18]}}
{"token": ["A", "36-year-old", "patient", "with", "C0520463#ent", "<e1>", "Coombs", "direct", "positive", "acute", "hemolytic", "anemia", "2", "weeks", "after", "a", "second", "course", "of", "C0007404#ent", "<e2>", "(", "Cy", ")", "."], "h": {"id": "C0520463", "name": "C0520463#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007404", "name": "C0007404#ent", "pos": [19, 20]}}
{"token": ["Although", "efficacy", "appears", "equivalent", "to", "that", "of", "C0016299#ent", "<e1>", "%", "in", "treating", "psoriasis", "of", "the", "C0240940#ent", "<e2>", ",", "desoximetasone", "appears", "to", "be", "slightly", "better", "tolerated", "and", "better", "accepted", "cosmetically", "."], "h": {"id": "C0016299", "name": "C0016299#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0240940", "name": "C0240940#ent", "pos": [15, 16]}}
{"token": ["Alcohol-free", "gels", "of", "C0005088#ent", "<e1>", "better", "tolerated", "by", "C0001144#ent", "<e2>", "patients", "than", "those", "containing", "alcohol", ",", "in", "particular", "when", "combined", "with", "topical", "tretinoin", "vitamin", "A", "acid", "treatment", "."], "h": {"id": "C0005088", "name": "C0005088#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0001144", "name": "C0001144#ent", "pos": [8, 9]}}
{"token": ["Biochemical", "experiments", "that", "C0669365#ent", "<e1>", "phosphorylation", "of", "Akt", "and", "IkappaBalpha", "correlates", "with", "NGF-induced", "C1540040#ent", "<e2>", "expression", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1540040", "name": "C1540040#ent", "pos": [13, 14]}}
{"token": ["C0885670#ent", "<e1>", "corrected", "plasma", "glucose", "had", "no", "effect", "on", "C0031644#ent", "<e2>", "mRNA", "and", "only", "partially", "normalized", "G-6-Pase", "mRNA", "."], "h": {"id": "C0885670", "name": "C0885670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [9, 10]}}
{"token": ["We", "studied", "the", "effect", "of", "the", "C3536853#ent", "<e1>", "acetazolamide", "on", "24", "patients", "with", "C1414474#ent", "<e2>", "patient", "self-evaluation", "of", "functional", "disability", "rating", "of", "motor", "task", "function", ",", "and", "clinical", "rating", "tremor", "severity", "."], "h": {"id": "C3536853", "name": "C3536853#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414474", "name": "C1414474#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", ",", "the", "effectiveness", "of", "alprazolam", ",", "a", "triazole", "analog", "benzodiazapine", "class", ",", "and", "acetazolamide", ",", "a", "C3536853#ent", "<e1>", "were", "investigated", "as", "symptomatic", "treatments", "for", "C1414474#ent", "<e2>"], "h": {"id": "C3536853", "name": "C3536853#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1414474", "name": "C1414474#ent", "pos": [28, 29]}}
{"token": ["Prenatal", "diagnosis", "disorders", "of", "galactose", "metabolism", "done", "in", "one", "instance", "in", "a", "family", "with", "a", "known", "C0268155#ent", "<e1>", "in", "six", "cases", "in", "five", "families", "at", "risk", "for", "C0016952#ent", "<e2>", "."], "h": {"id": "C0268155", "name": "C0268155#ent", "pos": [16, 17]}, "relation": "has_manifestation", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [27, 28]}}
{"token": ["Differentiation", "is", "induced", "by", "inhibition", "of", "DNA", "synthesis", "by", "dimethylsulfoxide", "(", "DMSO", ")", ",", "erythropoietin", "(", "EP", ")", "and", "Vitamin", "B12", "C1417635#ent", "<e1>", ")", ",", "and", "other", "C0035064#ent", "<e2>", "."], "h": {"id": "C1417635", "name": "C1417635#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [27, 28]}}
{"token": ["Data", "have", "been", "collected", "from", "47", "centers", "in", "Europe", "and", "North", "America", "the", "treatment", "with", "C0724529#ent", "<e1>", "of", "74", "acute", "bleeding", "episodes", "in", "65", "patients", "with", "acquired", "C0019069#ent", "<e2>", "."], "h": {"id": "C0724529", "name": "C0724529#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [27, 28]}}
{"token": ["Our", "results", "emphasize", "the", "role", "of", "C0724529#ent", "<e1>", "the", "treatment", "of", "C0019069#ent", "<e2>", "with", "inhibitors", "."], "h": {"id": "C0724529", "name": "C0724529#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [11, 12]}}
{"token": ["To", "examine", "whether", "the", "antioxidant", "C0001047#ent", "<e1>", "could", "ameliorate", "the", "course", "of", "the", "adult", "respiratory", "distress", "syndrome", "C0035222#ent", "<e2>", ")", "in", "man", "."], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [17, 18]}}
{"token": ["RT-PCR", "analysis", "that", "C3274729#ent", "<e1>", "lipomas", "with", "the", "fusion", "were", "591-fold", "of", "full-length", "C1333906#ent", "<e2>", "transcripts", "in", "lipomas", "without", "the", "fusion", "."], "h": {"id": "C3274729", "name": "C3274729#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333906", "name": "C1333906#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "in", "a", "number", "of", "lipomas", ",", "C3274729#ent", "<e1>", "and", "C1333906#ent", "<e2>", "are", "coexpressed", ",", "and", "C1333906#ent", "<e2>", "augments", "the", "transactivation", "functions", "of", "C3274729#ent", "<e1>", "."], "h": {"id": "C3274729", "name": "C3274729#ent", "pos": [8, 9]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333906", "name": "C1333906#ent", "pos": [11, 12]}}
{"token": ["C0035339#ent", "<e1>", "inhibit", "the", "function", "of", "the", "oncogenic", "C1333571#ent", "<e2>", "and", "beta-catenin/TCF", "pathways", "and", "also", "stabilize", "components", "of", "the", "adherens", "junction", "a", "tumor", "suppressor", "complex"], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "zilpaterol", "is", "a", "C2917450#ent", "<e1>", "an", "inhibitor", "of", "C0812246#ent", "<e2>", "production", "induced", "by", "LPS", "both", "in", "vivo", "in", "vitro"], "h": {"id": "C2917450", "name": "C2917450#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}}
{"token": ["The", "absence", "of", "C0020255#ent", "<e1>", "rather", "exceptional", "in", "such", "cases", ",", "where", "C0001622#ent", "<e2>", "of", "cerebrospinal", "fluid", "in", "an", "amount", "proportional", "to", "the", "tumoral", "mass", "is", "generally", "admitted", "."], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [12, 13]}}
{"token": ["Its", "mammalian", "C1334043#ent", "<e1>", "AIP1/Alix", "interacts", "with", "the", "C3715022#ent", "<e2>", "ALG-2", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3715022", "name": "C3715022#ent", "pos": [8, 9]}}
{"token": ["Melphalan", ",", "prednisolone", ",", "C0011777#ent", "<e1>", ",", "vincristine", ",", "doxorubicin", ",", "C1176309#ent", "<e2>", ",", "and", "thalidomide", "and", "its", "analogue", "lenalidomide", "have", "been", "used", "successfully", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1176309", "name": "C1176309#ent", "pos": [11, 12]}}
{"token": ["In", "these", "C0014493#ent", "<e1>", "the", "use", "of", "C0003949#ent", "<e2>", "was", "abandoned", "in", "1972", "."], "h": {"id": "C0014493", "name": "C0014493#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003949", "name": "C0003949#ent", "pos": [7, 8]}}
{"token": ["C1539747#ent", "<e1>", "PNUTL1", ")", "is", "a", "C3273624#ent", "<e2>", "is", "expressed", "at", "high", "levels", "in", "human", "brain", "."], "h": {"id": "C1539747", "name": "C1539747#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273624", "name": "C3273624#ent", "pos": [6, 7]}}
{"token": ["The", "objective", "of", "this", "study", "is", "to", "investigate", "C3149631#ent", "<e1>", "dosage", "regimens", "on", "C1415652#ent", "<e2>", ",", "COX-2", ",", "and", "prostaglandin", "dehydrogenase", "PGDH", ")", "expression", "in", "ovine", "intrauterine", "fetal", "tissues"], "h": {"id": "C3149631", "name": "C3149631#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [13, 14]}}
{"token": ["C3149631#ent", "<e1>", "effects", "are", "tissue", "specific", "and", "do", "not", "affect", "C1415652#ent", "<e2>", "or", "PGDH", "expression", "."], "h": {"id": "C3149631", "name": "C3149631#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [10, 11]}}
{"token": ["C0016295#ent", "<e1>", ",", "methiothepin", ",", "and", "C0040989#ent", "<e2>", ",", "but", "not", "haloperidol", ",", "reduced", "in", "vitro", "Ca(2+)-dependent", "[3H]5-HT", "release", "stimulated", "by", "0.5", "microM", "dF", "and", "dNF", "from", "superfused", "synaptosomes", "."], "h": {"id": "C0016295", "name": "C0016295#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040989", "name": "C0040989#ent", "pos": [6, 7]}}
{"token": ["Special", "attention", "given", "to", "laboratory", "techniques", "strategies", "currently", "exploited", "to", "C1875400#ent", "<e1>", "tumor-initiating", "cells", "larger", "populations", ",", "including", "their", "inherent", "strengths", "and", "C0018801#ent", "<e2>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [22, 23]}}
{"token": ["This", "review", "provides", "an", "overview", "of", "the", "three", "most", "widely", "used", "C0008429#ent", "<e1>", "(", "ChE", ")", "inhibitors", ":", "donepezil", ",", "C0649350#ent", "<e2>", ",", "and", "galantamine", "."], "h": {"id": "C0008429", "name": "C0008429#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0649350", "name": "C0649350#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "C0040615#ent", "<e1>", "such", "as", "haloperidol", "and", "C0072953#ent", "<e2>", "increase", "Fos-like", "immunoreactivity", "by", "blocking", "striatal", "D2", "dopamine", "receptors"], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072953", "name": "C0072953#ent", "pos": [9, 10]}}
{"token": ["Other", "C0040615#ent", "<e1>", "are", "D2", "receptor", "antagonists", "including", "haloperidol", ",", "C0072953#ent", "<e2>", ",", "sulpiride", ",", "remoxipride", "and", "loxapine", ",", "did", "not", "alter", "Fos", "expression", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072953", "name": "C0072953#ent", "pos": [10, 11]}}
{"token": ["It", "seems", "probable", "that", "repeated", "C0040615#ent", "<e1>", "(", "haloperidol", "and", "C0072953#ent", "<e2>", ")", "treatment", "causes", "the", "hyposensitivity", "of", "sigma", "and", "phencyclidine", "receptors", "despite", "the", "increase", "of", "their", "number", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0072953", "name": "C0072953#ent", "pos": [10, 11]}}
{"token": ["The", "complex", "C135S-C32S", "is", "prepared", "from", "forms", "of", "C1417458#ent", "<e1>", "and", "C1705610#ent", "<e2>", "altered", "by", "site-directed", "mutagenesis", "Cys138", "and", "Cys35", "are", "remaining", "in", "C1417458#ent", "<e1>", "and", "C1705610#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417458", "name": "C1417458#ent", "pos": [8, 9]}}
{"token": ["We", "tested", "whether", "C1743561#ent", "<e1>", "reduces", "the", "dose", "of", "C3887648#ent", "<e2>", "required", "to", "maintain", "mean", "arterial", "pressure", "MAP", ")", "in", "septic", "shock", "patients", "."], "h": {"id": "C1743561", "name": "C1743561#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [9, 10]}}
{"token": ["One", "domain", "closely", "resembles", "carboxy-", "and", "C0002570#ent", "<e1>", ",", "and", "features", "of", "membrane", "glutamate", "carboxypeptidase", "be", "deduced", "from", "the", "C1420708#ent", "<e2>", "structure", "."], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [19, 20]}}
{"token": ["The", "dysregulated", "tryptase", "in", "SOCS1-/-", "BMMCs", "is", "unlikely", "to", "be", "C1422417#ent", "<e1>", "or", "mMCP7", ",", "because", "the", "enzyme", "activity", "not", "inhibited", "by", "C0282194#ent", "<e2>", "but", "was", "inhibited", "by", "normal", "mouse", "plasma", "."], "h": {"id": "C1422417", "name": "C1422417#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282194", "name": "C0282194#ent", "pos": [22, 23]}}
{"token": ["Quaternization", "of", "C0033497#ent", "<e1>", "and", "the", "iodinated", "analogs", "eliminated", "the", "C0001645#ent", "<e2>", "retained", "the", "antiarrhythmic", "property", "of", "the", "secondary", "amine", "precursors", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [10, 11]}}
{"token": ["Phentolamine", "and", "C0033497#ent", "<e1>", "were", "used", "as", "C0001645#ent", "<e2>", "azaperone", "and", "haloperidol", "were", "used", "as", "unspecific", "antagonists", ",", "and", "domperidone", "as", "a", "specific", "dopamine", "antagonist", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [7, 8]}}
{"token": ["Finally", ",", "we", "found", "that", "Runx", "proteins", "suppress", "the", "transcription", "of", "an", "endogenous", "C1335875#ent", "<e1>", "target", "gene", ",", "C1426208#ent", "<e2>", "in", "an", "interleukin-3-dependent", "pro-B", "cell", "line", "Ba/F3", "."], "h": {"id": "C1335875", "name": "C1335875#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1426208", "name": "C1426208#ent", "pos": [18, 19]}}
{"token": ["Interestingly", ",", "Y532", "has", "been", "shown", "to", "be", "unnecessary", "for", "C1335875#ent", "<e1>", "activation", ",", "although", "C1426208#ent", "<e2>", "overexpression", "suppressed", "PRL-induced", "C1335875#ent", "<e1>", "activation", "."], "h": {"id": "C1335875", "name": "C1335875#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1426208", "name": "C1426208#ent", "pos": [15, 16]}}
{"token": ["Competitive", "binding", "assays", "various", "unlabelled", "C0038766#ent", "<e1>", "showed", "biphasic", "displacements", "of", "C0017628#ent", "<e2>", "coefficients", "significantly", "different", "from", "unity", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [5, 6]}, "relation": "chemical_structure_of", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [11, 12]}}
{"token": ["Newer", "C0038766#ent", "<e1>", ",", "such", "as", "glipizide", "and", "C0017628#ent", "<e2>", ",", "are", "more", "potent", "than", "the", "older", "ones", ",", "such", "as", "tolbutamide", "and", "chlorpropamide", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [8, 9]}}
{"token": ["Among", "the", "various", "drugs", "interfering", "with", "insulin", "secretion", "C0038766#ent", "<e1>", ",", "such", "as", "tolbutamide", "and", "C0017628#ent", "<e2>", ",", "directly", "inhibit", "ATP-dependent", "K+", "channels", "in", "the", "B", "cell", "membrane", "thereby", "initiate", "insulin", "release", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [8, 9]}, "relation": "chemical_structure_of", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [15, 16]}}
{"token": ["The", "activity", "of", "PZ-177", "was", "more", "potent", "than", "that", "of", "C0014581#ent", "<e1>", "and", "the", "same", "as", "that", "of", "C0031463#ent", "<e2>", "."], "h": {"id": "C0014581", "name": "C0014581#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031463", "name": "C0031463#ent", "pos": [18, 19]}}
{"token": ["Considering", "from", "therapeutic", "index", "M73101", "was", "found", "to", "be", "much", "superior", "to", "C0014581#ent", "<e1>", ",", "tiaramide", ",", "benzydamine", ",", "C0031463#ent", "<e2>", "and", "acetylsalicylic", "acid"], "h": {"id": "C0014581", "name": "C0014581#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031463", "name": "C0031463#ent", "pos": [19, 20]}}
{"token": ["Subjective", "improvement", "C0037199#ent", "<e1>", "and", "the", "lower", "C3714497#ent", "<e2>", "evaluated", "using", "a", "questionnaire", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3714497", "name": "C3714497#ent", "pos": [7, 8]}}
{"token": ["In", "cases", "with", "C0037199#ent", "<e1>", "and", "lower", "airway", "diseases", "continuous", "treatment", "C0037199#ent", "<e1>", "is", "necessary", "even", "after", "treatment", "of", "the", "lower", "C3714497#ent", "<e1>", "been", "completed", "."], "h": {"id": "C0037199", "name": "C0037199#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714497", "name": "C3714497#ent", "pos": [21, 22]}}
{"token": ["The", "comparison", "of", "this", "gene", "either", "at", "the", "nucleotide", "or", "at", "the", "protein", "level", "other", "HLA-DRB", "genes", "its", "inclusion", "in", "the", "C1705258#ent", "<e1>", "not", "in", "C0878555#ent", "<e2>", "or", "DQB", "gene", "families", "."], "h": {"id": "C1705258", "name": "C1705258#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0878555", "name": "C0878555#ent", "pos": [25, 26]}}
{"token": ["We", "suggest", "that", "supernumerary", "thumb", "likely", "a", "rare", "C0037285#ent", "<e1>", "C0272170#ent", "<e2>", "and", "that", "C0272170#ent", "<e2>", "should", "be", "considered", "in", "the", "differential", "diagnosis", "patients", "with", "bone", "marrow", "failure", "duplication", "of", "the", "thumb", "along", "with", "Blackfan-Diamond/Aase", "syndrome", "Fanconi's", "anemia"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [10, 11]}}
{"token": ["This", "con-stitutes", "a", "model", "system", "us", "to", "correlate", "the", "relative", "expression", "levels", "of", "the", "XPB-A355C", "(", "C2983123#ent", "<e1>", ")", "and", "XPB-T296C", "(", "XP/CS", ")", "genes", "with", "various", "C1333237#ent", "<e2>", "properties", "."], "h": {"id": "C2983123", "name": "C2983123#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [27, 28]}}
{"token": ["The", "cutaneous", "symptoms", "are", "associated", "with", "reduced", "transcription", "of", "a", "skin-specific", "gene", "strongly", "supporting", "the", "concept", "of", "C2983123#ent", "<e1>", "as", "a", "human", "disease", "to", "inborn", "defects", "in", "basal", "transcription", "C1333237#ent", "<e2>"], "h": {"id": "C2983123", "name": "C2983123#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [29, 30]}}
{"token": ["XP-D", "and", "most", "C2983123#ent", "<e1>", "patients", "have", "reduced", "levels", "of", "C1333237#ent", "<e2>", "but", "some", "recent", "reports", "have", "suggested", "that", "the", "repair", "deficiencies", "in", "TTD", "cells", "milder", "than", "in", "XP-D", "cells", "."], "h": {"id": "C2983123", "name": "C2983123#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [10, 11]}}
{"token": ["We", "report", "the", "prenatal", "diagnosis", "C2983123#ent", "<e1>", "in", "two", "French", "families", "based", "on", "C1333237#ent", "<e2>", "measurements", "in", "trophoblasts", "or", "amniotic", "cells", "with", "later", "confirmation", "by", "microscopic", "analysis", "the", "fetal", "hairs"], "h": {"id": "C2983123", "name": "C2983123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [13, 14]}}
{"token": ["C0021246#ent", "<e1>", "significantly", "attenuated", "the", "C3537240#ent", "<e2>", "effects", "of", "Ucn", "(", "P<0.05", ")", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [5, 6]}}
{"token": ["Indomethacin", "or", "SQ", "29.548", "(", "a", "thromboxane", "A2", "receptor", "antagonist", "did", "not", "affect", "the", "response", "to", "serotonin", ",", "whereas", "C0021246#ent", "<e1>", "reduced", "or", "abolished", "the", "C3537240#ent", "<e2>", "and", "vasoconstrictor", "action", "of", "PGE2", "and", "PGF2", "alpha"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [25, 26]}}
{"token": ["These", "responses", "were", "unaltered", "by", "the", "presence", "of", "10(-5", ")", "mol/l", "C0021246#ent", "<e1>", ",", "suggesting", "that", "prostacyclin", "is", "not", "a", "significant", "C3537240#ent", "<e2>", "in", "this", "system", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [21, 22]}}
{"token": ["Local", "oedema", "formation", "in", "the", "PCA", "was", "reduced", "by", "C0021246#ent", "<e1>", "suggesting", "that", "C3537240#ent", "<e2>", ",", "oedema-potentiating", "prostaglandins", "were", "released", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [13, 14]}}
{"token": ["DNA", "affinity", "chromatography", "by", "Western", "blot", "the", "binding", "of", "C1417701#ent", "<e1>", "transcription", "factor", "the", "immobilized", "C3274822#ent", "<e2>", "fragment", "and", "concomitant", "appearance", "of", "complex", "N", "EMSA", "of", "the", "eluted", "fractions", "."], "h": {"id": "C1417701", "name": "C1417701#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [15, 16]}}
{"token": ["The", "transcriptional", "regulation", "the", "cell", "cycle", "human", "C2987246#ent", "<e1>", "which", "encodes", "C1412854#ent", "<e2>", ",", "was", "investigated", "in", "this", "report", "."], "h": {"id": "C2987246", "name": "C2987246#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412854", "name": "C1412854#ent", "pos": [11, 12]}}
{"token": ["Enhancement", "of", "the", "C1706109#ent", "<e1>", "responses", "did", "not", "correlate", "with", "desensitization", "or", "activation", "of", "C0010536#ent", "<e2>", "suggest", "that", "prolonged", "PDBu", "treatment", "might", "sensitize", "a", "putative", "V1", "receptor-G-protein-phospholipase", "C", "complex", "."], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [14, 15]}}
{"token": ["In", "vitro", "binding", "and", "co-immunoprecipitation", "studies", "confirmed", "the", "protein-protein", "interaction", "hnRNP", "K", "C0252684#ent", "<e1>", ",", "and", "the", "region", "spanning", "C3539947#ent", "<e2>", "276", "of", "hnRNP", "K", "apparently", "responsible", "for", "its", "physical", "interaction", "C0252684#ent", "<e1>", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0252684", "name": "C0252684#ent", "pos": [12, 13]}}
{"token": ["Osteocondensation", "can", "result", "from", "decreased", "bone", "resorption", "malignant", "C0345407#ent", "<e1>", "been", "related", "to", "mutations", "in", "several", "C0017337#ent", "<e2>", "necessary", "for", "osteoclast", "function", "also", ",", "more", "recently", ",", "to", "osteoclast", "differentiation", "RANK-L", ")", "."], "h": {"id": "C0345407", "name": "C0345407#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["Both", "the", "Swiss", "and", "Puerto", "Rican", "C0242994#ent", "<e1>", "homozygotes", "and", "heterozygotes", "have", "C0017547#ent", "<e2>", "melanosomes", "in", "skin", "melanocytes"], "h": {"id": "C0242994", "name": "C0242994#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [12, 13]}}
{"token": ["Three", "of", "39", "(", "7.7", "%", ")", "cases", "showed", "mobility", "shifts", "the", "C1517488#ent", "<e1>", "no", "point", "mutations", "in", "NF1", "and", "C0027260#ent", "<e2>", "be", "detected", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027260", "name": "C0027260#ent", "pos": [20, 21]}}
{"token": ["However", ",", "analysis", "at", "codons", "12", ",", "13", ",", "and", "61", "in", "the", "C1517488#ent", "<e1>", "a", "A-->T", "transversion", "at", "codon", "61", "of", "the", "C0027260#ent", "<e2>", "a", "single", "tumor"], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027260", "name": "C0027260#ent", "pos": [23, 24]}}
{"token": ["During", "the", "period", "1987", "-", "1991", ",", "95", "(", "16.3", "%", ")", "C0025289#ent", "<e1>", "cases", "out", "of", "581", "C0025297#ent", "<e2>", "cases", "were", "observed", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [18, 19]}}
{"token": ["Male", "infants", "under", "the", "age", "of", "3", "months", "presenting", "with", "C0520575#ent", "<e1>", "in", "the", "presence", "of", "urinary", "tract", "malformation", "C1709289#ent", "<e2>", ")", "are", "prone", "to", "transient", "pseudohypoaldosteronism", "."], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1709289", "name": "C1709289#ent", "pos": [19, 20]}}
{"token": ["We", "assessed", "45", "persons", "with", "C0013080#ent", "<e1>", "and", "34", "with", "C0175702#ent", "<e2>", "(", "mean", "age", ")", "and", "81", "typically", "developing", "children", "(", "TD", ")", "."], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [10, 11]}}
{"token": ["C1334089#ent", "<e1>", "induced", "C/EBP", "alpha", "decreased", "C1413947#ent", "<e2>", "this", "might", "indicate", "that", "both", "transcription", "factors", "a", "reciprocal", "role", "in", "the", "expression", "of", "the", "tissue", "specific", "UCP", "gene"], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413947", "name": "C1413947#ent", "pos": [6, 7]}}
{"token": ["Assessments", "included", "the", "following", ":", "clinical", "examination", "discard", "previous", "C0878544#ent", "<e1>", ";", "search", "for", "the", "presence", "of", "C1705280#ent", "<e2>", "according", "to", "standard", "criteria", "specific", "serology", ";", "frontal", "chest", "X-ray", "and", "12-lead", "resting", "electrocardiogram", "ECG", ")", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [17, 18]}}
{"token": ["Because", "of", "these", "results", "and", "due", "to", "a", "preferential", "reactivity", "with", "C0017905#ent", "<e1>", "propose", "to", "designate", "this", "polymorphism", "only", "as", "C0061640#ent", "<e2>", "GOX-1", ")", "."], "h": {"id": "C0017905", "name": "C0017905#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0061640", "name": "C0061640#ent", "pos": [20, 21]}}
{"token": ["C1706512#ent", "<e1>", "was", "purified", "by", "HPLC", "and", "characterized", "in", "terms", "of", "C2917660#ent", "<e2>", "composition", "after", "acid", "hydrolysis", "protein", "sequencing", "gel", "electrophoretic", "behaviour", "."], "h": {"id": "C1706512", "name": "C1706512#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [11, 12]}}
{"token": ["Hemostasis", "markers", "measured", "C0052128#ent", "<e1>", "TAT", ")", ",", "fibrinogen", ",", "plasmin-alpha", "2-antiplasmin", "complexes", "(", "C1423108#ent", "<e2>", ")", ",", "plasminogen", "activator", "inhibitor", "PAI-1", ")", ",", "and", "D-dimer", "."], "h": {"id": "C0052128", "name": "C0052128#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [14, 15]}}
{"token": ["In", "all", "patients", "C0052128#ent", "<e1>", "TAT", ")", ",", "D-dimer", "(", "DD", ")", "and", "plasmin-antiplasmin", "complexes", "C1423108#ent", "<e2>", ")", ",", "antithrombin", "III", "activity", "fibrinogen/fibrin", "degradation", "products", "APTT", "and", "PT", "were", "determined", "."], "h": {"id": "C0052128", "name": "C0052128#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [15, 16]}}
{"token": ["During", "the", "last", "decade", ",", "several", "new", "C0003299#ent", "<e1>", "been", "released", ",", "e.g.", "lamotrigine", ",", "gabapentin", ",", "C0068897#ent", "<e2>", ",", "topiramate", "and", "levetiracetam", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0068897", "name": "C0068897#ent", "pos": [17, 18]}}
{"token": ["It", "is", "shown", "that", "some", "new", "C0003299#ent", "<e1>", "such", "as", "C0068897#ent", "<e2>", ",", "have", "spike-wave", "discharge-increasing", "properties", ",", "while", "other", "drugs", "are", "worth", "studying", "in", "clinical", "trials", "antiabsence", "treatment", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [6, 7]}, "relation": "therapeutic_class_of", "t": {"id": "C0068897", "name": "C0068897#ent", "pos": [10, 11]}}
{"token": ["On", "the", "other", "hand", ",", "new", "C0003299#ent", "<e1>", "such", "as", "levetiracetam", ",", "C0068897#ent", "<e2>", ",", "vigabatrine", "or", "lamotrigine", "had", "no", "effect", "thyroid", "hormones"], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [6, 7]}, "relation": "therapeutic_class_of", "t": {"id": "C0068897", "name": "C0068897#ent", "pos": [12, 13]}}
{"token": ["Four", "weeks", "after", "inoculation", ",", "behavioral", "signs", "were", "observed", "for", "mechanical", "allodynia", "cold", "allodynia", "and", "C0020429#ent", "<e1>", "using", "a", "von", "Frey", "filament", ",", "C0001002#ent", "<e2>", ",", "and", "radiant", "heat", "respectively", "."], "h": {"id": "C0020429", "name": "C0020429#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [23, 24]}}
{"token": ["C1-inhibitor", "is", "a", "C0072402#ent", "<e1>", "inhibitor", "that", "is", "active", "against", "C1s", ",", "C1r", ",", "C0022478#ent", "<e2>", ",", "and", "factor", "XII"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022478", "name": "C0022478#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", "we", "sought", "to", "compare", "the", "effects", "of", "and", "avitriptan", "on", "jugular", "vein", "C1335796#ent", "<e1>", "release", "after", "stimulation", "of", "the", "superior", "sagittal", "sinus", "C0037052#ent", "<e2>", ")", "in", "the", "cat", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0037052", "name": "C0037052#ent", "pos": [25, 26]}}
{"token": ["C1417250#ent", "<e1>", "has", "a", "C0812382#ent", "<e2>", "DSB", "formation", "and", "another", "site", "for", "DSB", "processing", "."], "h": {"id": "C1417250", "name": "C1417250#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [4, 5]}}
{"token": ["This", "study", "evaluated", "the", "association", "of", "a", "polymorphism", "in", "the", "CD40", "gene", "C0339510#ent", "<e1>", "and", "risk", "of", "C0029453#ent", "<e2>", "or", "osteoporosis", "in", "a", "population", "of", "602", "postmenopausal", "women", "."], "h": {"id": "C0339510", "name": "C0339510#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029453", "name": "C0029453#ent", "pos": [17, 18]}}
{"token": ["Conversely", ",", "b-AEA", "does", "not", "interact", "or", "interfere", "with", "other", "components", "of", "the", "C0006864#ent", "<e1>", "such", "as", "C0812270#ent", "<e2>", "and", "type-2", "cannabinoid", "receptors", "vanilloid", "receptor", "AEA", "synthetase", "N-acylphosphatidylethanolamine-hydrolyzing", "phospholipase", "D", ",", "or", "AEA", "hydrolase", "fatty", "acid", "amide", "hydrolase", "."], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812270", "name": "C0812270#ent", "pos": [17, 18]}}
{"token": ["A", "patient", "with", "S.", "japonicum", "C0851341#ent", "<e1>", "of", "the", "liver", "presented", "with", "C3854173#ent", "<e2>", "to", "retroperitoneal", "fibrosis", "together", "with", "the", "presence", "of", "low", "complement", "levels", "anti-nuclear", "and", "anti-DNA", "antibodies"], "h": {"id": "C0851341", "name": "C0851341#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [12, 13]}}
{"token": ["C0270932#ent", "<e1>", "of", "axonal", "and", "demyelinating", "types", ",", "and", "C0026848#ent", "<e2>", "have", "also", "been", "reported", "."], "h": {"id": "C0270932", "name": "C0270932#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [9, 10]}}
{"token": ["Morphological", "features", "of", "this", "necrotizing", "myopathy", "those", "of", "C0270932#ent", "<e1>", "than", "those", "of", "hypothyroid", "or", "C0026848#ent", "<e2>"], "h": {"id": "C0270932", "name": "C0270932#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [15, 16]}}
{"token": ["New", "immunosuppressive", "strategies", "may", "come", "from", "the", "availability", "of", "inhibitors", "of", "mTOR", ",", "a", "downstream", "effector", "of", "C0089793#ent", "<e1>", "provides", "the", "signal", "for", "cell", "proliferation", "phosphorylating", "a", "cascade", "of", "C0031727#ent", "<e2>", "."], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [17, 18]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [29, 30]}}
{"token": ["Expression", "of", "AtPI4Kalpha1", "without", "the", "PH", "domain", "the", "insect", "cells", "compromised", "C0089793#ent", "<e1>", "activity", "and", "caused", "mislocalization", "of", "the", "C0031727#ent", "<e2>", "."], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}}
{"token": ["In", "conclusion", "both", "metyrapone", "and", "C0002555#ent", "<e1>", "were", "useful", "as", "adjunctive", "therapy", "C0010481#ent", "<e2>"], "h": {"id": "C0002555", "name": "C0002555#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [12, 13]}}
{"token": ["Specifically", ",", "HeLa", "cells", "C0275524#ent", "<e1>", "with", "dl312", "and", "C1710332#ent", "<e2>", ",", "when", "shifted", "to", "the", "nonpermissive", "temperature", ",", "lost", "their", "capacity", "to", "express", "the", "early", "adenovirus", "genes"], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1710332", "name": "C1710332#ent", "pos": [9, 10]}}
{"token": ["These", "include", "acetylcholine", "(", "ACh", ")", ";", "choline", "acetyltransferase", "ChAT", ")", ",", "its", "synthesizing", "enzyme", ";", "and", "both", "C0026815#ent", "<e1>", "and", "nicotinic", "ACh", "receptors", "mAChRs", "and", "C1839729#ent", "<e2>", ",", "respectively", ")", "."], "h": {"id": "C0026815", "name": "C0026815#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1839729", "name": "C1839729#ent", "pos": [26, 27]}}
{"token": ["The", "localization", "of", "the", "amino", "acid", "changes", "in", "HA1", "to", "the", "region", "of", "the", "C0392475#ent", "<e1>", "supports", "the", "concept", "of", "C0003015#ent", "<e2>", "receptor", "analogs", "."], "h": {"id": "C0392475", "name": "C0392475#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [20, 21]}}
{"token": ["We", "report", "here", "that", "beta-TK", "and", "the", "chimeric", "gamma", "2-TK", "gene", "transfected", "into", "TK-", "baby", "hamster", "kidney", "(", "BHKtk-", ")", "were", "induced", "by", "C1334087#ent", "<e1>", "alpha", "0", "not", "by", "the", "other", "C2985256#ent", "<e2>"], "h": {"id": "C1334087", "name": "C1334087#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [31, 32]}}
{"token": ["When", "C1419980#ent", "<e1>", "-", "126", "was", "applied", "to", "cultures", "from", "mice", "lacking", "C2347435#ent", "<e2>", "expression", ",", "survival", "was", "equal", "to", "or", "greater", "than", "that", "of", "untreated", "control", "cells"], "h": {"id": "C1419980", "name": "C1419980#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [12, 13]}}
{"token": ["Estrogen", "treatment", "upregulated", "the", "levels", "of", "C0007209#ent", "<e1>", "such", "as", "atrial", "natriuretic", "peptide", "C1527149#ent", "<e2>", "in", "the", "heart", "."], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [13, 14]}}
{"token": ["In", "addition", "to", "their", "generalised", "role", "in", "intracellular", "protein", "degradation", "these", "two", "C3540790#ent", "<e1>", "are", "involved", "in", "the", "processing", "of", "thyrotrophin-releasing", "hormone", "C1421143#ent", "<e2>", ")", "in", "CNS", "tissues", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [22, 23]}}
{"token": ["The", "C3540790#ent", "<e1>", "concerned", "with", "the", "metabolism", "of", "C1421143#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [8, 9]}}
{"token": ["PC1", "and", "PC2", "are", "subtilisin-like", "processing", "C3540790#ent", "<e1>", "capable", "of", "C1421143#ent", "<e2>", "TRH", ")", "precursor", "(", "pro-TRH", ")", "at", "paired", "basic", "residues", "in", "vitro"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [10, 11]}}
{"token": ["In", "addition", "to", "their", "generalised", "role", "in", "intracellular", "protein", "degradation", "these", "two", "C3540790#ent", "<e1>", "are", "involved", "in", "the", "processing", "of", "C1421143#ent", "<e2>", "TRH", ")", "in", "CNS", "tissues", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [20, 21]}}
{"token": ["All", "regenerating", "motoneurons", "expressed", "C2987236#ent", "<e1>", ",", "but", "not", "C1705516#ent", "<e2>", ",", "while", "all", "motoneurons", "that", "failed", "to", "regenerate", "expressed", "C1705516#ent", "<e2>", ",", "but", "not", "C2987236#ent", "<e1>", "."], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987236", "name": "C2987236#ent", "pos": [4, 5]}}
{"token": ["The", "property", "of", "C0072603#ent", "<e1>", "to", "modify", "selectively", "the", "conformation(s", ")", "of", "C1705442#ent", "<e2>", "is", "also", "supported", "by", "its", "effect", "on", "heat-", "and", "urea-dependent", "denaturation", ",", "and", "tryptic", "digestion", "the", "protein", "."], "h": {"id": "C0072603", "name": "C0072603#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705442", "name": "C1705442#ent", "pos": [12, 13]}}
{"token": ["Because", "C0596110#ent", "<e1>", "enhance", "urinary", "thiamine", "excretion", ",", "practitioners", "should", "use", "caution", "for", "C0005122#ent", "<e2>", "they", "prescribe", "C0596110#ent", "<e1>", "for", "patients", "who", "have", "a", "history", "of", "upper", "gastrointestinal", "surgery", "potentially", "have", "latent", "C0005122#ent", "<e2>"], "h": {"id": "C0596110", "name": "C0596110#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0005122", "name": "C0005122#ent", "pos": [13, 14]}}
{"token": ["Insertion", "mutations", "in", "the", "C1704943#ent", "<e1>", "and", "palE", "genes", "the", "necessity", "of", "these", "C1417679#ent", "<e2>", "for", "bacterial", "growth", "chemotaxis", "with", "palatinose", "as", "the", "carbon", "source", ",", "but", "no", "inhibition", "of", "tumorigenesis", "was", "observed", "."], "h": {"id": "C1704943", "name": "C1704943#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["We", "have", "studied", "the", "distribution", "patterns", "of", "antigen-presenting", "cells", "C1456795#ent", "<e1>", ")", "in", "different", "stages", "of", "C0008312#ent", "<e2>", "PBC", ")", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [16, 17]}}
{"token": ["This", "calcium", "mobilization", "inhibited", "when", "C1706541#ent", "<e1>", "was", "co-cross-linked", "with", "C1870006#ent", "<e2>", ",", "suggesting", "that", "tyrosine", "phosphorylation", "also", "involved", "in", "C1706541#ent", "<e1>", "signaling", "."], "h": {"id": "C1706541", "name": "C1706541#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [10, 11]}}
{"token": ["Our", "data", "also", "show", "that", "C4054191#ent", "<e1>", "stimulation", "of", "C1366449#ent", "<e2>", "activity", "in", "terms", "of", "Gal4", "DNA-binding", "domain", "fusion", "is", "strictly", "ligand-dependent", "."], "h": {"id": "C4054191", "name": "C4054191#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366449", "name": "C1366449#ent", "pos": [9, 10]}}
{"token": ["Taken", "together", ",", "these", "results", "support", "the", "notion", "that", "C4054191#ent", "<e1>", "is", "a", "bona", "fide", "TR", "coactivator", "that", "C4054191#ent", "<e1>", "modulates", "C1366449#ent", "<e1>", "activity", "via", "a", "mechanism", "different", "from", "that", "utilized", "with", "peroxisome", "proliferator", "activator", "receptor-gamma"], "h": {"id": "C4054191", "name": "C4054191#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366449", "name": "C1366449#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "no", "consistent", "increase", "in", "in", "vitro", "C0003308#ent", "<e1>", "found", "to", "be", "associated", "with", "specific", "class", "of", "C1254351#ent", "<e2>", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["Cells", "treated", "with", "C0003308#ent", "<e1>", "concentrations", "of", "C1254351#ent", "<e2>", "were", "completely", "necrotic", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}}
{"token": ["This", "C0039082#ent", "<e1>", ",", "also", "known", "as", "C0271742#ent", "<e2>", "is", "now", "known", "to", "be", "caused", "by", "mutations", "in", "the", "AAAS", "gene"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0271742", "name": "C0271742#ent", "pos": [7, 8]}}
{"token": ["Further", ",", "our", "results", "corroborate", "earlier", "doubts", "that", "some", "patients", "with", "Sj\u00f8gren", "syndrome", "especially", "those", "with", "the", "so-called", "\"", "achalasia", "sicca", "C0039082#ent", "<e1>", "and", "adrenocortical", "insufficiency", "actually", "had", "C0271742#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [21, 22]}, "relation": "nichd_parent_of", "t": {"id": "C0271742", "name": "C0271742#ent", "pos": [28, 29]}}
{"token": ["Isometric", "strength", "different", "muscle", "groups", "recorded", "in", "thiryty-nine", "patients", "suffering", "various", "C0009450#ent", "<e1>", "predominantly", "of", "viral", "or", "C0026936#ent", "<e2>", "aetiology", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026936", "name": "C0026936#ent", "pos": [17, 18]}}
{"token": ["In", "conclusion", ",", "slow-release", "metoprolol", "association", "with", "C0008294#ent", "<e1>", "provides", "a", "safe", "and", "effective", "treatment", "of", "C0020538#ent", "<e2>", "on", "a", "long-term", "basis", "."], "h": {"id": "C0008294", "name": "C0008294#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "the", "association", "of", "C0008294#ent", "<e1>", "and", "retard", "nifedipine", "does", "not", "improve", "the", "treatment", "of", "C0020538#ent", "<e2>", "to", "retard", "nifedipine", "."], "h": {"id": "C0008294", "name": "C0008294#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["Because", "ECE", ",", "NEP", ",", "and", "ACE", "play", "regulatory", "roles", "cardiovascular", "and", "renal", "function", "triple", "inhibitors", "these", "C3540790#ent", "<e1>", "may", "represent", "a", "novel", "class", "of", "C0035064#ent", "<e2>", "for", "treatment", "of", "cardiovascular", "and", "renal", "diseases"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [25, 26]}}
{"token": ["To", "investigate", "the", "in", "vivo", "osteogenic", "feasibility", "of", "tissue", "engineered", "C0151846#ent", "<e1>", "constructed", "by", "porcine", "C0751995#ent", "<e2>", "and", "BMSCs", "in", "allogenic", "New", "Zealand", "rabbit"], "h": {"id": "C0151846", "name": "C0151846#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751995", "name": "C0751995#ent", "pos": [15, 16]}}
{"token": ["Further", ",", "C0034049#ent", "<e1>", "cystic", "fibrosis", "be", "linked", "to", "the", "dysfunction", "of", "C4084937#ent", "<e2>"], "h": {"id": "C0034049", "name": "C0034049#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4084937", "name": "C4084937#ent", "pos": [12, 13]}}
{"token": ["The", "association", "constant", "for", "C0031716#ent", "<e1>", "was", "6X10(4", ")", "M-1", "FOR", "C1706005#ent", "<e2>", "FR", "and", "the", "7S", "subunit", "as", "determined", "by", "fluorescence", "titration", "a", "value", "in", "agreement", "with", "the", "obtained", "by", "equilibrium", "dialysis"], "h": {"id": "C0031716", "name": "C0031716#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [11, 12]}}
{"token": ["Canavan", "disease", "CD", ")", "is", "a", "fatal", "C1285162#ent", "<e1>", "by", "mutations", "in", "the", "gene", "for", "aspartoacylase", ",", "an", "C0027203#ent", "<e2>", "that", "hydrolyzes", "N-acetylaspartate", "(", "NAA", ")", "into", "L-aspartate", "and", "acetate", "."], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["Spectratype", "analysis", "C0017351#ent", "<e1>", "CDR3", "repertoire", "revealed", "a", "gradual", "normalization", "in", "C1706005#ent", "<e2>", "spectratype", "complexity", "by", "6", "-", "12", "months", "after", "transplant", "."], "h": {"id": "C0017351", "name": "C0017351#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [11, 12]}}
{"token": ["Direct", "immunofluorescence", "DIF", ")", "study", "showed", "C0017351#ent", "<e1>", "IgG", ")", "and", "less", "intense", "deposits", "of", "IgA", ",", "C1706005#ent", "<e2>", ",", "C(3", ")", "and", "C(1q", ")", "surrounding", "superficial", "and", "deep", "vessels", "the", "reticular", "dermis"], "h": {"id": "C0017351", "name": "C0017351#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [17, 18]}}
{"token": ["Sections", "of", "the", "C0017337#ent", "<e1>", "encoding", "the", "alpha-", "and", "beta-subunits", "of", "ATP", "C0001156#ent", "<e2>", "be", "amplified", "from", "both", "organisms", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001156", "name": "C0001156#ent", "pos": [12, 13]}}
{"token": ["Molecular", "inflammation", "a", "pivotal", "process", "in", "various", "C1456654#ent", "<e1>", "including", "asthma", "and", "C0013595#ent", "<e2>"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [12, 13]}}
{"token": ["Phenotype", "analysis", "flow", "cytometry", "Western", "blotting", "that", "C1425155#ent", "<e1>", "expressed", "more", "placental", "alkaline", "phosphatase", "C1412365#ent", "<e2>", ")", "than", "GPIIIa", "."], "h": {"id": "C1425155", "name": "C1425155#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412365", "name": "C1412365#ent", "pos": [14, 15]}}
{"token": ["The", "cytochromes", "P450", "C0534137#ent", "<e1>", ")", "are", "a", "C0017363#ent", "<e2>", "enzymes", "with", "a", "central", "role", "in", "the", "oxidative", "metabolism", "a", "wide", "range", "of", "xenobiotics", ",", "including", "anticancer", "drugs", "carcinogens", ",", "and", "endogenous", "compounds", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [8, 9]}}
{"token": ["Since", "then", ",", "these", "compounds", "have", "been", "extensively", "studied", "and", "other", "biological", "properties", "been", "discovered", ":", "inhibition", "of", "C1333828#ent", "<e1>", ",", "of", "glycogen", "phosphorylase", "of", "C3887659#ent", "<e2>", "etc", "."], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887659", "name": "C3887659#ent", "pos": [25, 26]}}
{"token": ["AtT-20", "cells", "contain", "two", "molecular", "weight", "forms", "87", "and", "66", "kDa", ")", "of", "the", "C1258132#ent", "<e1>", "also", "known", "as", "C1423866#ent", "<e2>", ")", ",", "thought", "to", "be", "involved", "in", "prohormone", "maturation", "."], "h": {"id": "C1258132", "name": "C1258132#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1423866", "name": "C1423866#ent", "pos": [19, 20]}}
{"token": ["C0019114#ent", "<e1>", "may", "have", "a", "detrimental", "effect", "on", "some", "C0008679#ent", "<e2>"], "h": {"id": "C0019114", "name": "C0019114#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [9, 10]}}
{"token": ["The", "GI", "tract", "included", "biopsies", "from", "3", "patients", "who", "had", "C0037284#ent", "<e1>", "from", "7", "patients", "in", "whom", "there", "were", "no", "known", "C0037274#ent", "<e2>"], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [21, 22]}}
{"token": ["C1968833#ent", "<e1>", "is", "known", "to", "regulate", "vascular", "endothelial", "growth", "factor", "C2349086#ent", "<e2>", ")", "expression", ",", "and", "thereby", "tumor", "angiogenesis", "."], "h": {"id": "C1968833", "name": "C1968833#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [10, 11]}}
{"token": ["CSF", "cell", "fell", "into", "normal", "range", "administration", "of", "C0016277#ent", "<e1>", "(", "800", "mg/day", ")", "for", "thirteen", "months", ",", "but", "C0020258#ent", "<e2>", "continued", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020258", "name": "C0020258#ent", "pos": [19, 20]}}
{"token": ["Human", "homologue", "of", "the", "Drosophila", "discs", "large", "C0079427#ent", "<e1>", "hDlg", ")", "belongs", "to", "a", "newly", "discovered", "family", "of", "C0086376#ent", "<e2>", "termed", "MAGUKs", "that", "appear", "to", "have", "structural", "as", "well", "as", "signaling", "functions"], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "suggest", "that", "TOPORS", "may", "function", "as", "a", "C0079427#ent", "<e1>", "regulating", "mSin3A", "and", "other", "C0086376#ent", "<e2>", "involved", "in", "chromatin", "modification"], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["Transfected", "cells", "expressing", "the", "amino-terminal", "half", "hNopp140", ",", "hNopp140N382", "(", "C3539946#ent", "<e1>", "382", ")", ",", "displayed", "altered", "C1417613#ent", "<e2>", "with", "crescent-shaped", "structures", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [17, 18]}}
{"token": ["Clonidine", "or", "C0018312#ent", "<e1>", "used", "to", "detoxify", "subjects", "who", "received", "C2343921#ent", "<e2>", "within", "10", "days", "of", "their", "last", "dose", "of", "opioid", "."], "h": {"id": "C0018312", "name": "C0018312#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2343921", "name": "C2343921#ent", "pos": [10, 11]}}
{"token": ["The", "cytologic", "sample", "yielded", "clear", "fluid", "containing", "numerous", "clearly", "identifiable", "protoscoleces", "diagnostic", "for", "C0013502#ent", "<e1>", "using", "routine", "C1423108#ent", "<e2>", "staining", "."], "h": {"id": "C0013502", "name": "C0013502#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "using", "point", "mutations", "in", "the", "effector", "loop", "C1335647#ent", "<e1>", ",", "we", "show", "that", "the", "interaction", "of", "C1335647#ent", "<e1>", "with", "C0139905#ent", "<e1>", "is", "crucial", "for", "transformation", "."], "h": {"id": "C1335647", "name": "C1335647#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [21, 22]}}
{"token": ["First", "we", "determined", "the", "basis", "for", "the", "inability", "of", "C1335647#ent", "<e1>", "to", "activate", "C0139905#ent", "<e2>", "."], "h": {"id": "C1335647", "name": "C1335647#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [13, 14]}}
{"token": ["Several", "Arabidopsis", "knockout", "mutant", "lines", "C0017337#ent", "<e1>", "involved", "in", "polyester", "biosynthesis", "att1", ",", "fatB", "and", "C1540194#ent", "<e2>", ")", "were", "examined", "for", "seed", "monomer", "load", "and", "composition", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1540194", "name": "C1540194#ent", "pos": [15, 16]}}
{"token": ["A", "5-year-old", "boy", "with", "adrenoleukodystrophy", ",", "with", "clinical", "symptoms", "visual", ",", "mental", "and", "motor", "disturbances", "progressed", "rapidly", ",", "was", "treated", "with", "C0212874#ent", "<e1>", "1", "volume", "of", "glyceryl", "trierucate", "4", "volumes", "of", "C0041073#ent", "<e2>"], "h": {"id": "C0212874", "name": "C0212874#ent", "pos": [21, 22]}, "relation": "has_product_component", "t": {"id": "C0041073", "name": "C0041073#ent", "pos": [31, 32]}}
{"token": ["In", "addition", ",", "human", "neural", "stem", "cell", "differentiation", "nerve", "growth", "C1705592#ent", "<e1>", "PC12", "cell", "were", "also", "inhibited", "by", "C0006864#ent", "<e2>"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006864", "name": "C0006864#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "we", "observed", "specific", "association", "of", "C1706351#ent", "<e1>", "and", "the", "p85", "subunit", "PI", "3-kinase", "incubation", "of", "the", "GST-CT", "with", "C1417609#ent", "<e2>"], "h": {"id": "C1706351", "name": "C1706351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417609", "name": "C1417609#ent", "pos": [20, 21]}}
{"token": ["This", "mutation", "was", "previously", "described", "as", "a", "cause", "of", "X-linked", "thrombocytopenia", "thalassemia", "(", "C1839161#ent", "<e1>", ")", "but", "not", "of", "C0270276#ent", "<e2>"], "h": {"id": "C1839161", "name": "C1839161#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0270276", "name": "C0270276#ent", "pos": [19, 20]}}
{"token": ["Our", "findings", "suggest", "that", "C1839161#ent", "<e1>", "is", "within", "a", "spectrum", "of", "disorders", "constituting", "the", "C0270276#ent", "<e2>", "and", "we", "propose", "that", "GATA1", "is", "an", "upstream", "regulator", "the", "genes", "required", "for", "platelet", "alpha-granule", "biogenesis"], "h": {"id": "C1839161", "name": "C1839161#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0270276", "name": "C0270276#ent", "pos": [14, 15]}}
{"token": ["C0086110#ent", "<e1>", "very", "frequent", "in", "C0524909#ent", "<e2>", "8/28", ")", ",", "non-alcoholic", "cirrhosis", "24/55", ")", "and", "HCC", "(", "14/29", ")", "."], "h": {"id": "C0086110", "name": "C0086110#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [5, 6]}}
{"token": ["C0086110#ent", "<e1>", "present", "in", "the", "sahelian", "region", ";", "Patients", "with", "acute", "viral", "hepatitis", "C0524909#ent", "<e2>", "non", "alcoholic", "hepatic", "cirrhosis", "and", "hepatocellular", "carcinoma", "electively", "infected", "."], "h": {"id": "C0086110", "name": "C0086110#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [13, 14]}}
{"token": ["Compared", "to", "argon", "laser", "treatment", "patients", "found", "diode", "laser", "treatment", "more", "C0030193#ent", "<e1>", ",", "but", "appreciated", "the", "absence", "of", "C0085635#ent", "<e2>", "therapy", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085635", "name": "C0085635#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "both", "Rac1", "and", "C1418259#ent", "<e1>", "regulate", "the", "recently", "described", "IRF-3", "activators", "I", "kappa", "B", "kinase-", "C1449326#ent", "<e2>", "establishing", "a", "first", "canonical", "virus-induced", "IRF-3", "activating", "pathway", "."], "h": {"id": "C1418259", "name": "C1418259#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1449326", "name": "C1449326#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "inhaled", "C1161352#ent", "<e1>", "(", "an", "anticholinergic", "drug", "may", "be", "preferable", "to", "C0029193#ent", "<e2>", "a", "beta-adrenergic", "agonist", "when", "additional", "bronchodilation", "is", "needed", "in", "patients", "with", "chronic", "obstructive", "pulmonary", "disease", "high-normal", "serum", "theophylline", "levels", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029193", "name": "C0029193#ent", "pos": [14, 15]}}
{"token": ["We", "hypothesized", "that", "E1A", "might", "inhibit", "C1418372#ent", "<e1>", "gene", "transcription", "binding", "to", "C1705458#ent", "<e2>", "and/or", "CBP", "."], "h": {"id": "C1418372", "name": "C1418372#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705458", "name": "C1705458#ent", "pos": [12, 13]}}
{"token": ["The", "C1865361#ent", "<e1>", "electrodes", "have", "been", "used", "to", "determine", "C0020306#ent", "<e2>", "by", "differential", "pulse", "voltammetry", "."], "h": {"id": "C1865361", "name": "C1865361#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020306", "name": "C0020306#ent", "pos": [9, 10]}}
{"token": ["Our", "data", "provide", "the", "first", "evidence", "that", "C1416706#ent", "<e1>", "stimulations", "can", "act", "to", "suppress", "C0016399#ent", "<e2>", "hippocampal", "kindling", "and", "suggest", "a", "new", "approach", "for", "seizure", "control", "in", "temporal", "lobe", "epilepsy"], "h": {"id": "C1416706", "name": "C1416706#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016399", "name": "C0016399#ent", "pos": [14, 15]}}
{"token": ["Ninety", "per", "cent", "of", "pancreatic", "adenocarcinomas", "PC", ")", "contain", "mutations", "of", "the", "C0079973#ent", "<e1>", "proto-oncogene", "resulting", "in", "constitutively", "activated", "C0220304#ent", "<e2>"], "h": {"id": "C0079973", "name": "C0079973#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0220304", "name": "C0220304#ent", "pos": [19, 20]}}
{"token": ["Eighteen", "out", "of", "57", "patients", "(", "31", "-", "6", "per", "cent", ")", "suffering", "from", "Familial", "Mediterranean", "Fever", "C0031069#ent", "<e1>", ")", "were", "found", "to", "have", "the", "C0027726#ent", "<e2>", "histologically", "proven", "amyloidosis", "and", "progressive", "renal", "failure"], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [25, 26]}}
{"token": ["C1419723#ent", "<e1>", "has", "83", "amino", "acids", "a", "molecular", "weight", "9,121", ";", "C1419673#ent", "<e2>", "has", "50", "amino", "acids", "a", "molecular", "weight", "6,271", "."], "h": {"id": "C1419723", "name": "C1419723#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419673", "name": "C1419673#ent", "pos": [11, 12]}}
{"token": ["The", "mRNA", "for", "C1419723#ent", "<e1>", "is", "about", "500", "nucleotides", "in", "length", "and", "for", "C1419673#ent", "<e2>", "it", "is", "about", "450", "."], "h": {"id": "C1419723", "name": "C1419723#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419673", "name": "C1419673#ent", "pos": [13, 14]}}
{"token": ["C1415467#ent", "<e1>", "was", "not", "converted", "to", "prostaglandins", "or", "C0003693#ent", "<e2>", "the", "endothelial", "cultures"], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [8, 9]}}
{"token": ["Sequence", "alignment", "phylogenetic", "analysis", "the", "C1413723#ent", "<e1>", "indicate", "that", "the", "protein", "has", "similarity", "with", "human", "dendritic", "cell", "immunoreceptor", "C1539093#ent", "<e2>", ")", ",", "gp120", "binding", "C-type", "lectin", "(", "gp120BCL", ")", "and", "mammalian", "hepatic", "lectins"], "h": {"id": "C1413723", "name": "C1413723#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539093", "name": "C1539093#ent", "pos": [18, 19]}}
{"token": ["Sequence", "alignment", "phylogenetic", "analysis", "the", "C1413723#ent", "<e1>", "indicate", "that", "the", "protein", "has", "similarity", "with", "human", "C1539093#ent", "<e2>", "DCIR", ")", ",", "gp120", "binding", "C-type", "lectin", "(", "gp120BCL", ")", "and", "mammalian", "hepatic", "lectins"], "h": {"id": "C1413723", "name": "C1413723#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539093", "name": "C1539093#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "pneumococcal", "capsular", "typing", "received", "renewed", "interest", "since", "the", "availability", "of", "C2981859#ent", "<e1>", "which", "include", "serotypes", "frequently", "associated", "with", "C3272758#ent", "<e2>"], "h": {"id": "C2981859", "name": "C2981859#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3272758", "name": "C3272758#ent", "pos": [20, 21]}}
{"token": ["Here", "we", "report", "that", "C1413171#ent", "<e1>", "a", "nuclear", "protein", "in", "a", "C0751283#ent", "<e2>"], "h": {"id": "C1413171", "name": "C1413171#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751283", "name": "C0751283#ent", "pos": [11, 12]}}
{"token": ["A", "patient", "with", "C0152171#ent", "<e1>", "no", "metabolism", "of", "C0058310#ent", "<e2>", "in", "the", "pulmonary", "circulation"], "h": {"id": "C0152171", "name": "C0152171#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [8, 9]}}
{"token": ["There", "was", "no", "clinical", "evidence", "histamine", "release", "in", "the", "groups", "receiving", "51W89", "besylate", "compared", "to", "two", "out", "of", "the", "19", "patients", "who", "had", "C0016382#ent", "<e1>", "the", "administration", "of", "C0004234#ent", "<e2>", "."], "h": {"id": "C0016382", "name": "C0016382#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0004234", "name": "C0004234#ent", "pos": [28, 29]}}
{"token": ["Subsequently", ",", "antibodies", "against", "C0032143#ent", "<e1>", "tPA", ")", "increased", "NO", "production", "in", "endotoxin-treated", "mixed", "glial", "cell", "cultures", "C0002502#ent", "<e2>", ",", "an", "inhibitor", "for", "urokinase", "(", "uPA", ")", ",", "had", "no", "effect"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "when", "the", "slices", "were", "stimulated", "by", "trains", "of", "10", "pulses", "at", "0.033", "Hz", ",", "C0085228#ent", "<e1>", "shifted", "the", "concentration-response", "curve", "C0000589#ent", "<e2>", "to", "the", "right", "."], "h": {"id": "C0085228", "name": "C0085228#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0000589", "name": "C0000589#ent", "pos": [23, 24]}}
{"token": ["In", "this", "review", ",", "evidence", "is", "provided", "that", "supports", "the", "involvement", "of", "various", "P-450", "isozymes", "but", "especially", "C1142644#ent", "<e1>", "and", "other", "isozymes", "of", "the", "C1176140#ent", "<e2>"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [24, 25]}}
{"token": ["Significantly", ",", "no", "change", "in", "the", "Engrailed-2", "mutant", "phenotype", "occurs", "after", "a", "similar", "background", "switch", ",", "and", "whole-mount", "in", "situ", "hybridization", "identical", "C1414396#ent", "<e1>", "expression", "patterns", "in", "C2987364#ent", "<e2>", "C57BL/6J", "and", "129/Sv", "mice", "."], "h": {"id": "C1414396", "name": "C1414396#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [27, 28]}}
{"token": ["Acute", "changes", "involving", "the", "hormones", "thyroxine", "T4", ")", "and", "triiodothyronine", "(", "T3", ")", "followed", "by", "hyper", "-or", "C0271801#ent", "<e1>", "crises", "will", "lead", "to", "both", "cardiovascular", "and", "C0005944#ent", "<e2>"], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [26, 27]}}
{"token": ["C0311370#ent", "<e1>", "been", "noticed", "in", "association", "with", "C0004364#ent", "<e2>", "early-onset", "severe", "preeclampsia", "."], "h": {"id": "C0311370", "name": "C0311370#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [7, 8]}}
{"token": ["C0311370#ent", "<e1>", "a", "group", "of", "antibodies", "commonly", "found", "in", "patients", "with", "C0004364#ent", "<e2>", "as", "systemic", "lupus", "erythematosus"], "h": {"id": "C0311370", "name": "C0311370#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [11, 12]}}
{"token": ["Such", "inhibitors", "were", "first", "described", "in", "lupus", "erythematodes", "therefore", "called", "C0311370#ent", "<e1>", "but", "later", "also", "demonstrated", "in", "other", "C0004364#ent", "<e2>"], "h": {"id": "C0311370", "name": "C0311370#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [18, 19]}}
{"token": ["C1332125#ent", "<e1>", "utilizes", "two", "distinct", "domains", "for", "interaction", "with", "MEKK1", "and", "C0666248#ent", "<e2>", "."], "h": {"id": "C1332125", "name": "C1332125#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0666248", "name": "C0666248#ent", "pos": [11, 12]}}
{"token": ["SH2", "domain", "BCR/ABL", "mutants", "deficient", "in", "PI-3k", "activation", "failed", "to", "stimulate", "Akt", "kinase", "a", "recently", "identified", "PI-3k", "downstream", "effector", "with", "oncogenic", "potential", ",", "but", "did", "activate", "C3470429#ent", "<e1>", "RAS", "and", "C1136240#ent", "<e2>"], "h": {"id": "C3470429", "name": "C3470429#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1136240", "name": "C1136240#ent", "pos": [30, 31]}}
{"token": ["We", "report", "the", "case", "of", "an", "intensive", "care", "unit", "patient", "with", "C0264490#ent", "<e1>", "by", "severe", "community-acquired", "pneumonia", "C0014013#ent", "<e2>", "."], "h": {"id": "C0264490", "name": "C0264490#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014013", "name": "C0014013#ent", "pos": [17, 18]}}
{"token": ["Three", "cases", "illustrate", "that", "C0264490#ent", "<e1>", "be", "precipitated", "by", "spontaneous", "drainage", "of", "lung", "abscess", "C0014013#ent", "<e2>", "intrabronchially", "with", "diffuse", "aspiration", "of", "the", "contents", "bilaterally", "."], "h": {"id": "C0264490", "name": "C0264490#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014013", "name": "C0014013#ent", "pos": [14, 15]}}
{"token": ["Indeed", ",", "C1414438#ent", "<e1>", "induced", "the", "transient", "tyrosine", "phosphorylation", "C1423732#ent", "<e2>", "in", "UT-7", "cells", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423732", "name": "C1423732#ent", "pos": [9, 10]}}
{"token": ["Both", "kinetics", "and", "C1414438#ent", "<e1>", "dose-response", "experiments", "showed", "that", "C1423732#ent", "<e2>", "tyrosine", "phosphorylation", "was", "a", "direct", "consequence", "of", "Epo", "receptor", "activation", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423732", "name": "C1423732#ent", "pos": [9, 10]}}
{"token": ["Chronic", "elevation", "of", "SAH", ",", "secondary", "to", "homocysteine-mediated", "reversal", "of", "the", "C0050795#ent", "<e1>", "reduces", "methylation", "of", "DNA", ",", "RNA", ",", "C0086376#ent", "<e2>", ",", "and", "phospholipids", "."], "h": {"id": "C0050795", "name": "C0050795#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "a", "histochemical", "chromogenic", "method", "is", "now", "available", ",", "which", "allows", "the", "reliable", "detection", "of", "C1174250#ent", "<e1>", "was", "already", "possible", "for", "DPP", "II", "using", "an", "C2984879#ent", "<e2>", "substrate", "."], "h": {"id": "C1174250", "name": "C1174250#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2984879", "name": "C2984879#ent", "pos": [27, 28]}}
{"token": ["We", "previously", "reported", "that", "squalestatin", "1-mediated", "induction", "of", "C1539208#ent", "<e1>", "expression", "is", "attributable", "to", "C1414563#ent", "<e2>", "inhibition", "and", "accumulation", "of", "an", "endogenous", "isoprenoid(s", ")", "that", "is", "capable", "of", "activating", "the", "constitutive", "androstane", "receptor"], "h": {"id": "C1539208", "name": "C1539208#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414563", "name": "C1414563#ent", "pos": [14, 15]}}
{"token": ["The", "mechanism", "by", "which", "C0388638#ent", "<e1>", ",", "a", "marine", "C1512076#ent", "<e2>", "early", "clinical", "development", "an", "anticancer", "agent", "induces", "cell", "growth", "inhibition", "and", "apoptosis", "has", "been", "investigated", "in", "the", "human", "leukemia", "cell", "line", "MOLT-4", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1512076", "name": "C1512076#ent", "pos": [9, 10]}}
{"token": ["Forepaw", "padding", "was", "strongly", "inhibited", "by", "methergoline", "and", "a", "high", "dose", "mianserin", ",", "and", "weakly", "antagonized", "by", "C0025842#ent", "<e1>", ",", "clozapine", ",", "haloperidol", "and", "C0039943#ent", "<e2>", "."], "h": {"id": "C0025842", "name": "C0025842#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0039943", "name": "C0039943#ent", "pos": [24, 25]}}
{"token": ["The", "magnitude", "of", "the", "reduction", "of", "the", "C0014442#ent", "<e1>", "in", "the", "specific", "granules", "paralleled", "that", "of", "C1420652#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420652", "name": "C1420652#ent", "pos": [16, 17]}}
{"token": ["Groups", "of", "hamsters", "were", "immunized", "subcutaneously", "with", "a", "C1096184#ent", "<e1>", "recombinant", "envelope", "protein", "80E", ")", "with", "or", "without", "C1096184#ent", "<e1>", "non-structural", "protein", "1", "C1706044#ent", "<e1>", ")", "mixed", "with", "adjuvant", "or", "adjuvant", "alone", "."], "h": {"id": "C1096184", "name": "C1096184#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [23, 24]}}
{"token": ["Periarthropathia", "humeroscapularis", "(", "C1705397#ent", "<e1>", ")", "is", "a", "malfunction", "of", "the", "shoulder", "girdle", "primarily", "to", "C0012634#ent", "<e2>", "of", "the", "periarticular", "tissue", "the", "joint", "capsule"], "h": {"id": "C1705397", "name": "C1705397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["The", "human", "homolog", "of", "MAT1", "and", "C1710327#ent", "<e1>", "is", "the", "human", "AT", "C0062773#ent", "<e2>", ")", "."], "h": {"id": "C1710327", "name": "C1710327#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [12, 13]}}
{"token": ["It", "has", "been", "shown", "that", "C0003805#ent", "<e1>", ",", "3beta-hydroxysteroid", "C0030016#ent", "<e2>", "and", "17beta-hydroxysteroid", "C0030016#ent", "<e2>", "(", "17beta-HSD", ")", "are", "inhibited", "by", "the", "isoflavones", ",", "genistein", "and", "daidzein", ",", "and", "by", "coumestrol", "."], "h": {"id": "C0003805", "name": "C0003805#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [9, 10]}}
{"token": ["Ca2", "+", "-ATPase", "but", "not", "C1428925#ent", "<e1>", "underwent", "phosphorylation", "by", "C0249866#ent", "<e2>", "PLBab-treated", "SR", "with", "resultant", "stimulation", "of", "Ca2", "+", "uptake", "."], "h": {"id": "C1428925", "name": "C1428925#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0249866", "name": "C0249866#ent", "pos": [10, 11]}}
{"token": ["C3539541#ent", "<e1>", "is", "a", "C1417406#ent", "<e2>", "expressed", "in", "highly", "metastatic", "tumours"], "h": {"id": "C3539541", "name": "C3539541#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417406", "name": "C1417406#ent", "pos": [4, 5]}}
{"token": ["C0126174#ent", "<e1>", "alone", "or", "combined", "therapy", "reduced", "plasma", "sCD40L", "levels", "more", "than", "C0074554#ent", "<e2>", "alone", "in", "our", "subjects", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0074554", "name": "C0074554#ent", "pos": [12, 13]}}
{"token": ["The", "following", "histochemical", "reactions", "carried", "out", "successfully", ":", "the", "tetrazolium", "salt", "reaction", "C0030016#ent", "<e1>", "and", "reductase", "activity", "the", "post-azo-coupling", "method", "for", "acid", "phosphatase", "C1332804#ent", "<e2>", "and", "the", "simultaneous", "azo-coupling", "method", "for", "esterase", "activity"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [23, 24]}}
{"token": ["112", "C0947912#ent", "<e1>", "(", "14.5", "%", ")", "have", "another", "associated", "C0004364#ent", "<e2>"], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [10, 11]}}
{"token": ["Thus", "these", "key", "innate<-->adaptive", "immune", "intermediaries", "are", "now", "implicated", "in", "APS1", "and", "C0947912#ent", "<e1>", "well", "as", "in", "systemic", "lupus", "erythematosus", "other", "C0004364#ent", "<e2>"], "h": {"id": "C0947912", "name": "C0947912#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [21, 22]}}
{"token": ["We", "show", "in", "this", "report", "that", "C0075193#ent", "<e1>", ",", "a", "kinase", "inhibitor", "induces", "the", "expression", "of", "the", "C4084890#ent", "<e2>", "Y1", "adrenocortical", "cells", "possibly", "a", "result", "of", "an", "increase", "in", "the", "population", "of", "dephospho-TORC", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4084890", "name": "C4084890#ent", "pos": [17, 18]}}
{"token": ["In", "the", "pig", ",", "we", "have", "described", "seven", "MC1R", "alleles", "controlling", "four", "different", "coat", "color", "phenotypes", "(", "C1883559#ent", "<e1>", "dominant", "black", ",", "black", "spotting", "and", "C0017361#ent", "<e2>", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [25, 26]}}
{"token": ["The", "effect", "of", "reactive", "oxygen", "species", "by", "the", "interaction", "of", "xanthine", "and", "C0043317#ent", "<e1>", "synaptic", "transmission", "examined", "at", "the", "squid", "giant", "synapse", "and", "the", "C0751950#ent", "<e2>"], "h": {"id": "C0043317", "name": "C0043317#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [24, 25]}}
{"token": ["A", "non-synonymous", "coding", "polymorphism", "the", "C0534628#ent", "<e1>", "thought", "to", "affect", "C0534628#ent", "<e1>", "activity", "."], "h": {"id": "C0534628", "name": "C0534628#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0534628", "name": "C0534628#ent", "pos": [5, 6]}}
{"token": ["Bovine", "milk", "QSOX1", "is", "highly", "active", "toward", "reduced", "C0014241#ent", "<e1>", "and", "with", "the", "model", "C0012789#ent", "<e2>"], "h": {"id": "C0014241", "name": "C0014241#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [14, 15]}}
{"token": ["C2348049#ent", "<e1>", "is", "a", "splice", "variant", "the", "predominant", "maintenance", "activity", "DNMT1", ",", "while", "C1823482#ent", "<e2>", "is", "a", "well-conserved", "protein", "with", "homologs", "in", "plants", ",", "yeast", ",", "Drosophila", ",", "humans", ",", "and", "mice", "."], "h": {"id": "C2348049", "name": "C2348049#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823482", "name": "C1823482#ent", "pos": [13, 14]}}
{"token": ["Yet", "caution", "is", "required", "when", "even", "calcium", "antagonists", "especially", "C0042523#ent", "<e1>", ",", "are", "given", "to", "patients", "with", "myocardial", "failure", "caused", "by", "C0020538#ent", "<e2>"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [21, 22]}}
{"token": ["In", "our", "study", ",", "we", "used", "enalapril", ",", "furosemide", "and", "C0042523#ent", "<e1>", "for", "treatment", "of", "C0020538#ent", "<e2>", "cardiac", "transplant", "recipients", "and", "investigated", "the", "influence", "of", "these", "drugs", "on", "ciclosporin", "whole", "blood", "levels", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [15, 16]}}
{"token": ["Yet", "caution", "is", "required", "when", "calcium", "antagonists", "especially", "C0042523#ent", "<e1>", ",", "are", "given", "to", "patients", "with", "myocardial", "failure", "caused", "by", "C0020538#ent", "<e2>"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [20, 21]}}
{"token": ["S.", "oralis", "is", "known", "to", "produce", "glucosyltransferase", "(", "C2697657#ent", "<e1>", ")", ",", "which", "synthesizes", "glucans", "from", "C1161331#ent", "<e2>", "."], "h": {"id": "C2697657", "name": "C2697657#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [16, 17]}}
{"token": ["The", "adult", "form", "of", "Tay-Sachs", "disease", "adult", "C0268274#ent", "<e1>", "is", "an", "C3899988#ent", "<e2>", "results", "from", "mutations", "in", "the", "alpha", "chain", "of", "beta-hexosaminidase", "A.", "This", "disorder", "like", "infantile", "Tay-Sachs", "disease", "is", "more", "frequent", "in", "the", "Ashkenazi", "Jewish", "population"], "h": {"id": "C0268274", "name": "C0268274#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [11, 12]}}
{"token": ["Progressive", "proximal", "muscle", "weakness", "present", "both", "in", "spinal", "muscular", "atrophy", "SMA", ")", "type", "III", "(", "Kugelberg-Welander", "disease", "and", "in", "C0268274#ent", "<e1>", "diseases", "that", "segregate", "in", "an", "C3899988#ent", "<e2>"], "h": {"id": "C0268274", "name": "C0268274#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [26, 27]}}
{"token": ["Transformed", "E.", "coli", "cells", "able", "to", "synthesize", "either", "a", "fusion", "protein", "comprising", "the", "first", "seven", "C3539946#ent", "<e1>", "beta-galactosidase", ",", "a", "linker", "fragment", "bovine", "FGF", ",", "or", "C0017428#ent", "<e2>", "bFGF", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [26, 27]}}
{"token": ["The", "electrophoretic", "mobilities", "of", "both", "I-cell", "and", "normal", "C0005220#ent", "<e1>", "to", "decrease", "after", "treatment", "with", "C0027803#ent", "<e2>", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027803", "name": "C0027803#ent", "pos": [15, 16]}}
{"token": ["No", "isolate", "from", "C3889252#ent", "<e1>", "produced", "Panton-Valentine", "leucocidin", "(", "C0023529#ent", "<e2>", ")", ",", "whereas", "21.5", "%", "of", "the", "S.", "aureus", "isolates", "from", "CUH", "produced", "C0023529#ent", "<e2>", "(", "P<0.01", ")", "."], "h": {"id": "C3889252", "name": "C3889252#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023529", "name": "C0023529#ent", "pos": [9, 10]}}
{"token": ["These", "combine", "the", "deficiency", "of", "C1858160#ent", "<e1>", "with", "that", "of", "C1313359#ent", "<e2>", ",", "a", "gene", "coding", "the", "mammalian", "repair", "glycosylase", "that", "initiates", "the", "base", "excision", "repair", "7,8-dihydro-8-oxoguanine", "(", "8-oxoG", ")", "."], "h": {"id": "C1858160", "name": "C1858160#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1313359", "name": "C1313359#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "evidence", "is", "presented", "to", "support", "the", "hypothesis", "that", "wild", "type", "C1858160#ent", "<e1>", "regulates", "expression", "of", "C1313359#ent", "<e2>", "."], "h": {"id": "C1858160", "name": "C1858160#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1313359", "name": "C1313359#ent", "pos": [17, 18]}}
{"token": ["The", "C0003308#ent", "<e1>", "tested", "were", "amphotericin", "B", "flucytosine", ",", "fluconazole", ",", "itraconazole", ",", "C0393080#ent", "<e2>", ",", "and", "isavuconazole", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0393080", "name": "C0393080#ent", "pos": [13, 14]}}
{"token": ["The", "importance", "of", "renal", "acid-base", "transport", "has", "been", "highlighted", "by", "mutations", "identified", "in", "several", "C0086376#ent", "<e1>", "involved", "in", "this", "C1416596#ent", "<e2>", "in", "patients", "with", "inborn", "forms", "of", "renal", "tubular", "acidosis"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [19, 20]}}
{"token": ["The", "purpose", "of", "the", "present", "investigation", "was", "to", "study", "the", "distensibility", "of", "the", "ascending", "aorta", "patients", "with", "C0020538#ent", "<e1>", "normal", "subjects", "and", "after", "administration", "of", "a", "calcium", "antagonist", "C0028066#ent", "<e2>", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [28, 29]}}
{"token": ["These", "results", "suggest", "that", "the", "association", "of", "chlorthalidone", "and", "retard", "C0028066#ent", "<e1>", "does", "not", "improve", "the", "treatment", "of", "C0020538#ent", "<e2>", "to", "retard", "C0028066#ent", "<e1>", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [10, 11]}}
{"token": ["C0054757#ent", "<e1>", "EC", "3.4.17.10", ",", "also", "known", "as", "enkephalin", "convertase", "carboxypeptidase", "E", "and", "C0007075#ent", "<e2>", "is", "an", "important", "enzyme", "involved", "in", "the", "biosynthesis", "of", "bioactive", "peptides", "."], "h": {"id": "C0054757", "name": "C0054757#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007075", "name": "C0007075#ent", "pos": [13, 14]}}
{"token": ["Carboxypeptidase", "E", "C0054757#ent", "<e1>", ")", "is", "highly", "concentrated", "in", "neuroendocrine", "tissues", "is", "the", "only", "C0007075#ent", "<e2>", "detected", "in", "mature", "secretory", "vesicles"], "h": {"id": "C0054757", "name": "C0054757#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007075", "name": "C0007075#ent", "pos": [14, 15]}}
{"token": ["Here", "I", "discuss", "potential", "applications", "of", "RNAi", "to", "inclusion-body", "myositis", "C0238190#ent", "<e1>", ")", "after", "first", "reviewing", "its", "application", "more", "generally", "to", "C0027765#ent", "<e2>"], "h": {"id": "C0238190", "name": "C0238190#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [21, 22]}}
{"token": ["Addition", "of", "an", "inhibitor", "of", "C0010531#ent", "<e1>", "H89", ",", "or", "an", "inhibitor", "of", "MMPs", ",", "C1608879#ent", "<e2>", ",", "significantly", "suppressed", "bone-resorbing", "activity", "induced", "by", "PGE(2", ".", ")"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1608879", "name": "C1608879#ent", "pos": [15, 16]}}
{"token": ["These", "proteins", "include", "four", "Kr\u00fcppel-like", "proteins", "BTEB2", ",", "C1416660#ent", "<e1>", ",", "LKLF", ",", "and", "C1418596#ent", "<e2>", ")", "and", "other", "factors", "containing", "multiple", "zinc", "finger", "motifs", "TFIIIA", "and", "MZFP", ")", "."], "h": {"id": "C1416660", "name": "C1416660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418596", "name": "C1418596#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "provide", "evidence", "that", "C2713519#ent", "<e1>", "act", "as", "a", "C1825958#ent", "<e2>", "and", "mammalian", "cells", "possess", "bacterial", "type", "fatty", "acid", "synthetase", "FAS", "type", "II", "in", "mitochondria", ",", "in", "addition", "to", "FAS", "type", "I", "the", "cytoplasm", "."], "h": {"id": "C2713519", "name": "C2713519#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1825958", "name": "C1825958#ent", "pos": [10, 11]}}
{"token": ["In", "utero", "C0178879#ent", "<e1>", "cause", "urine", "retention", "functioning", "C0722058#ent", "<e2>", "and", "lead", "to", "glomerular", "cysts", "the", "nephrogenic", "zone"], "h": {"id": "C0178879", "name": "C0178879#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0722058", "name": "C0722058#ent", "pos": [8, 9]}}
{"token": ["In", "utero", "C0178879#ent", "<e1>", "cause", "urine", "retention", "functioning", "C0722058#ent", "<e2>", "and", "lead", "to", "multiple", "cyst", "formation", "in", "the", "nephrogenic", "zone"], "h": {"id": "C0178879", "name": "C0178879#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0722058", "name": "C0722058#ent", "pos": [8, 9]}}
{"token": ["The", "deduced", "amino", "acid", "sequences", "hupA", ",", "hupB", "and", "hupC", "are", "C1334043#ent", "<e1>", "to", "the", "Escherichia", "coli", "hypA", "C1822686#ent", "<e2>", "and", "hypC", "gene", "products", ",", "respectively", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1822686", "name": "C1822686#ent", "pos": [18, 19]}}
{"token": ["The", "complementary", "DNA", "sequence", "the", "human", "insulin", "receptor", "similar", "to", "those", "of", "the", "EGF", "receptor", "C1706111#ent", "<e1>", "and", "products", "of", "the", "C0038085#ent", "<e2>", "oncogenes", "."], "h": {"id": "C1706111", "name": "C1706111#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [21, 22]}}
{"token": ["X", "linked", "hyper-IgM", "(", "XHIM", ")", "is", "a", "primary", "immunodeficiency", "by", "mutations", "in", "the", "C1336652#ent", "<e1>", "TNFSF5", ",", "also", "known", "as", "the", "C1539081#ent", "<e2>", "ligand", "(", "CD40L", ")", "gene", "."], "h": {"id": "C1336652", "name": "C1336652#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1539081", "name": "C1539081#ent", "pos": [22, 23]}}
{"token": ["We", "have", "previously", "described", "the", "prevalence", "of", "C4022604#ent", "<e1>", "in", "biopsy", "specimens", "Australian", "Aborigines", "with", "C0022658#ent", "<e2>", "a", "phenomenon", "documented", "in", "a", "number", "of", "other", "indigenous", "populations"], "h": {"id": "C4022604", "name": "C4022604#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", ",", "we", "have", "examined", "the", "effects", "IL-2", ",", "C1334091#ent", "<e1>", "and", "TSA", "have", "on", "C1333891#ent", "<e2>", "expression", "in", "the", "human", "hepatocellular", "carcinoma", "cell", "line", "."], "h": {"id": "C1334091", "name": "C1334091#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [17, 18]}}
{"token": ["C0280858#ent", "<e1>", "and", "tetracain", "potentiated", "the", "inhibitory", "effect", "on", "aggregation", "of", "C0012695#ent", "<e2>", ",", "dibutyryl", "cAMP", "and", "C0012695#ent", "<e2>", "plus", "dibutyryl", "cAMP", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [11, 12]}}
{"token": ["It", "was", "concluded", "that", "C0053611#ent", "<e1>", "causes", "less", "C0001641#ent", "<e2>", "amitriptylene", "but", "that", "the", "sympathomimetic", "effects", "similar", "."], "h": {"id": "C0053611", "name": "C0053611#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [8, 9]}}
{"token": ["Certain", "cysteine-containing", "proteins", ",", "such", "bovine", "serum", "albumin", ",", "ovalbumin", "and", "cytochrome", "c", "reacted", "with", "C1956063#ent", "<e1>", ",", "while", "others", ",", "including", "carbonic", "anhydrase", "soybean", "trypsin", "inhibitor", "bovine-lung", "trypsin", "inhibitor", "C0031711#ent", "<e2>", "not", "."], "h": {"id": "C1956063", "name": "C1956063#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031711", "name": "C0031711#ent", "pos": [30, 31]}}
{"token": ["Similar", "results", "were", "obtained", "in", "investigating", "different", "grades", "of", "C3273254#ent", "<e1>", "transition", "into", "secondary", "C0027719#ent", "<e2>", "conditioned", "by", "hypertension", "and", "in", "chronic", "diffuse", "sclerosing", "interstitial", "nephritides", "different", "etiologies", "."], "h": {"id": "C3273254", "name": "C3273254#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027719", "name": "C0027719#ent", "pos": [14, 15]}}
{"token": ["It", "prevented", "derepression", "of", "C0001156#ent", "<e1>", "fructose-1,6-diphosphatase", "and", "C0002272#ent", "<e2>", "in", "a", "constitutive", "but", "glucose", "sensitive", "C0002272#ent", "<e2>", "mutant", "."], "h": {"id": "C0001156", "name": "C0001156#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [8, 9]}}
{"token": ["Cellular", "transfection", "C1412552#ent", "<e1>", "cytosolic", "retention", "C1334478#ent", "<e2>", "and", "enhanced", "C1334478#ent", "<e2>", "phosphorylation", "stimulated", "by", "ASK1", "."], "h": {"id": "C1412552", "name": "C1412552#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334478", "name": "C1334478#ent", "pos": [6, 7]}}
{"token": ["Studies", "described", "here", "examine", "the", "functional", "significance", "of", "C1413821#ent", "<e1>", "inhibition", "on", "autoantigen", "presentation", "C0004364#ent", "<e2>", "a", "murine", "model", "for", "Sj\u00f6gren", "syndrome"], "h": {"id": "C1413821", "name": "C1413821#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [14, 15]}}
{"token": ["C0291573#ent", "<e1>", "(", "p32", ")", "is", "processed", "by", "upstream", "caspases", "to", "C1422411#ent", "<e2>", "and", "p20", "subunits", ",", "which", "heterodimerize", "."], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422411", "name": "C1422411#ent", "pos": [11, 12]}}
{"token": ["Neuropathy", "Target", "Esterase", "(", "C3889152#ent", "<e1>", ")", "is", "the", "molecular", "target", "the", "nervous", "system", "organophosphorus", "esters", "C0338271#ent", "<e2>", ")", "when", "they", "cause", "delayed", "polyneuropathy", "."], "h": {"id": "C3889152", "name": "C3889152#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [16, 17]}}
{"token": ["Twenty-four", "hr", "lymphocyte", "neurotoxic", "esterase", "(", "C3889152#ent", "<e1>", ")", "inhibition", "was", "used", "as", "an", "index", "of", "brain", "C3889152#ent", "<e1>", "inhibition", "for", "the", "various", "organophosphorus", "compound", "C0338271#ent", "<e1>", ")", "treatment", "."], "h": {"id": "C3889152", "name": "C3889152#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [25, 26]}}
{"token": ["Covalent", "modification", "C3889152#ent", "<e1>", ",", "a", "neuronal", "protein", "serine", "esterase", "activity", "by", "certain", "organophosphates", "(", "C0338271#ent", "<e2>", ")", "initiates", "degeneration", "of", "long", "axons", "the", "peripheral", "and", "central", "nervous", "system"], "h": {"id": "C3889152", "name": "C3889152#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [15, 16]}}
{"token": ["Neither", "activation", "system", "cell", "viability", "the", "activity", "of", "AChE", "or", "C3889152#ent", "<e1>", "in", "the", "absence", "of", "C0338271#ent", "<e2>", "compounds", "."], "h": {"id": "C3889152", "name": "C3889152#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [16, 17]}}
{"token": ["Clinical", "differentiation", "parkinsonian", "syndromes", "as", "the", "C4255233#ent", "<e1>", "variant", "of", "multiple", "system", "atrophy", "MSA-P", ")", "and", "progressive", "supranuclear", "palsy", "C1332754#ent", "<e2>", ")", "from", "Parkinson's", "disease", "difficult", "in", "the", "early", "stage", "the", "disease", "."], "h": {"id": "C4255233", "name": "C4255233#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [19, 20]}}
{"token": ["Moreover", ",", "parallel", "to", "the", "effect", "on", "PKC", "activity", ",", "C0033216#ent", "<e1>", "was", "more", "potent", "than", "tetracaine", "as", "a", "C0087140#ent", "<e2>", "inducer", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [19, 20]}}
{"token": ["Nineteen", "patients", "with", "moderate", "or", "severe", "pain", "due", "to", "C0038013#ent", "<e1>", "entered", "into", "a", "double-blind", ",", "crossover", "comparison", "single", "doses", "550", "mg", "C0546873#ent", "<e2>", "900", "mg", "soluble", "aspirin", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0546873", "name": "C0546873#ent", "pos": [22, 23]}}
{"token": ["To", "elucidate", "the", "potential", "role", "of", "the", "C0017337#ent", "<e1>", "prostate", "cancer", "progression", ",", "we", "have", "stably-transfected", "the", "C1366526#ent", "<e2>", "human", "prostate", "cancer", "cell", "line", "an", "C0017337#ent", "<e1>", "vector", "."], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}}
{"token": ["To", "obtain", "comprehensive", "gene", "expression", "altered", "by", "I3C-", "and", "DIM-treated", "C1366526#ent", "<e1>", "we", "utilized", "cDNA", "microarray", "interrogate", "the", "expression", "of", "22,215", "known", "C0017337#ent", "<e2>", "using", "the", "Affymetrix", "Human", "Genome", "U133A", "Array", "."], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [22, 23]}}
{"token": ["To", "better", "understand", "the", "precise", "molecular", "mechanism(s", ")", "by", "which", "genistein", "exerts", "its", "effects", "on", "C1366526#ent", "<e1>", "we", "utilized", "cDNA", "microarray", "interrogate", "12,558", "known", "C0017337#ent", "<e2>", "to", "determine", "the", "gene", "expression", "altered", "by", "genistein", "treatment"], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}}
{"token": ["Unlike", "blood", "DC", "monocyte-derived", "DC", "C1704862#ent", "<e1>", ")", ",", "differentiated", "in", "vitro", "not", "express", "C1366449#ent", "<e2>", "and", "were", "unresponsive", "to", "thrombin", "."], "h": {"id": "C1704862", "name": "C1704862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366449", "name": "C1366449#ent", "pos": [14, 15]}}
{"token": ["Expression", "of", "C0907533#ent", "<e1>", "active", "p90Rsk", "with", "C1709313#ent", "<e2>", ",", "oncogenic", "H-Ras", ",", "and", "hTERT", "resulted", "in", "the", "anchorage-independent", "growth", "normal", "human", "fibroblasts", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [7, 8]}}
{"token": ["CHO", "cell", "lines", "C0907533#ent", "<e1>", "expressing", "wild-type", "and", "mutant", "C1709313#ent", "<e2>", "been", "derived", "which", "can", "serve", "as", "new", "host", "cell", "lines", "transient", "expression", "and", "efficient", "stable", "expression", "without", "gene", "amplification"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [9, 10]}}
{"token": ["These", "gene", "expression", "were", "blocked", "by", "C0907533#ent", "<e1>", "expression", "of", "the", "wild-type", "HPV16", "E7", "or", "adenovirus", "C1709313#ent", "<e2>", "but", "not", "by", "E7", "or", "E1A", "mutants", "defective", "for", "Rb", "binding", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [16, 17]}}
{"token": ["Interferon-gamma", "is", "the", "most", "important", "cytokine", "in", "resistance", "to", "C0004623#ent", "<e1>", "common", "variants", "of", "interferon-gamma", "gene", "be", "related", "to", "C0041296#ent", "<e2>", "susceptibility", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [19, 20]}}
{"token": ["C0004623#ent", "<e1>", "in", "particular", "C0041296#ent", "<e2>", ",", "was", "the", "most", "common", "type", "of", "infection", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [4, 5]}}
{"token": ["The", "effects", "on", "the", "spontaneous", "activity", "the", "C2699120#ent", "<e1>", "were", "in", "good", "correspondence", "to", "those", "on", "the", "C0599295#ent", "<e2>"], "h": {"id": "C2699120", "name": "C2699120#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [17, 18]}}
{"token": ["We", "describe", "two", "patients", "with", "unusual", "features", "of", "focal", "intracranial", "phycomycosis", ":", "a", "diabetic", "patient", "with", "C0270629#ent", "<e1>", "a", "healthy", "individual", "with", "an", "isolated", "C1510428#ent", "<e2>"], "h": {"id": "C0270629", "name": "C0270629#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1510428", "name": "C1510428#ent", "pos": [24, 25]}}
{"token": ["C0031007#ent", "<e1>", "is", "an", "effective", "drug", "in", "patients", "with", "advanced", "C0030567#ent", "<e2>", "reduces", "\"", "on-off", "\"", "phenomena", "."], "h": {"id": "C0031007", "name": "C0031007#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [10, 11]}}
{"token": ["The", "potential", "utility", "of", "c-mpl", "ligands", "treatment", "of", "myelodysplastic", "syndromes", "C0002874#ent", "<e1>", "or", "in", "C0019693#ent", "<e2>", "will", "have", "to", "be", "evaluated", "in", "the", "future", "."], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [14, 15]}}
{"token": ["Diseases", "such", "as", "C0002874#ent", "<e1>", "leukemia", ",", "and", "C0019693#ent", "<e2>", "being", "treated", "with", "bone", "marrow", "transplantation"], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [8, 9]}}
{"token": ["C0011816#ent", "<e1>", "induced", "the", "expression", "of", "C2346625#ent", "<e2>", "dramatically", "in", "the", "absence", "of", "de", "novo", "protein", "synthesis"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2346625", "name": "C2346625#ent", "pos": [6, 7]}}
{"token": ["IRG", "proteins", ",", "or", "C3273299#ent", "<e1>", "also", "known", "as", "C0018296#ent", "<e2>", ",", "are", "a", "group", "of", "IFN-regulated", "proteins", "that", "are", "highly", "expressed", "in", "response", "to", "infection", "."], "h": {"id": "C3273299", "name": "C3273299#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [9, 10]}}
{"token": ["C0242172#ent", "<e1>", "PID", ")", "is", "the", "most", "common", "serious", "complication", "of", "C0036916#ent", "<e2>", "STDs", ")", "."], "h": {"id": "C0242172", "name": "C0242172#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [11, 12]}}
{"token": ["Protein", "efficiency", "ratios", "PER", ";", "weight", "gain", "unit", "of", "protein", "intake", "were", "determined", "in", "chicks", "fed", "10", "%", "CP", "diets", "containing", "a", "C0075019#ent", "<e1>", "as", "the", "only", "source", "of", "C0012177#ent", "<e2>"], "h": {"id": "C0075019", "name": "C0075019#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0012177", "name": "C0012177#ent", "pos": [29, 30]}}
{"token": ["Links", "among", "unexpected", "targets", "also", "emerged", ",", "among", "them", "that", "methadone", ",", "emetine", "and", "loperamide", "(", "C0591635#ent", "<e1>", ")", "may", "antagonize", "muscarinic", "M3", "C0304513#ent", "<e2>", "neurokinin", "NK2", "receptors", "respectively", "."], "h": {"id": "C0591635", "name": "C0591635#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0304513", "name": "C0304513#ent", "pos": [23, 24]}}
{"token": ["Our", "aim", "was", "to", "examine", "the", "association", "between", "use", "of", "C0001962#ent", "<e1>", "and", "subsequent", "incidence", "of", "C0553573#ent", "<e2>"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0553573", "name": "C0553573#ent", "pos": [16, 17]}}
{"token": ["Of", "these", "29", "cases", ",", "23", "were", "associated", "with", "C0014121#ent", "<e1>", "two", "with", "C0264757#ent", "<e2>", "fusion", "and/or", "shrinkage", "of", "the", "chordae", "tendineae", "three", "with", "mitral", "valve", "prolapse", "myxomatous", "degeneration", "the", "mitral", "valve", "and", "one", "with", "aortitis", "syndrome"], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0264757", "name": "C0264757#ent", "pos": [13, 14]}}
{"token": ["Both", "patients", "suffered", "from", "C0014121#ent", "<e1>", "the", "aortic", "valve", "superimposed", "on", "previous", "C0264757#ent", "<e2>"], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0264757", "name": "C0264757#ent", "pos": [12, 13]}}
{"token": ["More", "time", "was", "C3273338#ent", "<e1>", "and", "more", "strokes", "employed", "brushing", "C0236000#ent", "<e2>", "than", "maxillary", "arches", "labial", "and", "buccal", "than", "occlusal", "areas", "and", "occlusal", "than", "lingual", "areas"], "h": {"id": "C3273338", "name": "C3273338#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0236000", "name": "C0236000#ent", "pos": [10, 11]}}
{"token": ["Dietary", "administration", "ethoxyquin", "(", "EQ", ")", "and", "methionine", "hydroxy", "analog", "C3273545#ent", "<e1>", ")", "induced", "the", "C0599532#ent", "<e2>", "concentrations", "in", "liver", ",", "kidney", ",", "small", "intestine", "stomach", "of", "mice", "accompanied", "with", "hepatic", "hypertrophy"], "h": {"id": "C3273545", "name": "C3273545#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [15, 16]}}
{"token": ["The", "most", "common", "types", "of", "C0011849#ent", "<e1>", "observed", "in", "a", "primary", "care", "practice", "type", "1", ",", "type", "2", "and", "C0085207#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "that", "the", "risk", "of", "C0011849#ent", "<e1>", "associated", "with", "low", "birth", "weight", "strongly", "related", "to", "the", "development", "of", "C0085207#ent", "<e2>", "suggesting", "a", "genetic", "link", "lower", "birth", "weight", "later", "C0011849#ent", "<e1>", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [19, 20]}}
{"token": ["The", "reasons", "for", "referral", "included", "a", "positive", "family", "history", "C0011849#ent", "<e1>", "or", "a", "history", "of", "C0085207#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [15, 16]}}
{"token": ["Since", "de", "novo", "synthesis", "of", "methyl", "groups", "the", "participation", "of", "C1258127#ent", "<e1>", "we", "investigated", "the", "effect", "of", "C0016412#ent", "<e2>", "pancreatic", "exocrine", "function"], "h": {"id": "C1258127", "name": "C1258127#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0016412", "name": "C0016412#ent", "pos": [17, 18]}}
{"token": ["The", "glycoside", "hydrolase", "18", "GH18", ")", "family", "of", "C1413391#ent", "<e1>", "is", "an", "ancient", "C1335597#ent", "<e2>", "expressed", "in", "archea", ",", "prokaryotes", "and", "eukaryotes", "."], "h": {"id": "C1413391", "name": "C1413391#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335597", "name": "C1335597#ent", "pos": [13, 14]}}
{"token": ["A", "broader", "spectrum", "tyrosine", "kinase", "inhibitor", "C0600438#ent", "<e1>", "also", "completely", "eliminated", "the", "SIN-1-induced", "C0242900#ent", "<e2>", "release", "."], "h": {"id": "C0600438", "name": "C0600438#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242900", "name": "C0242900#ent", "pos": [13, 14]}}
{"token": ["MP", "produced", "no", "increase", "in", "plasma", "levels", "renin", "activity", "C3669212#ent", "<e1>", ")", ",", "cortisol", ",", "potassium", ",", "or", "C3714642#ent", "<e2>", "."], "h": {"id": "C3669212", "name": "C3669212#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [18, 19]}}
{"token": ["C3669212#ent", "<e1>", "was", "also", "decreased", ",", "probably", "secondary", "to", "increased", "C3714642#ent", "<e2>", "and/or", "fluid", "retention"], "h": {"id": "C3669212", "name": "C3669212#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [10, 11]}}
{"token": ["C0033229#ent", "<e1>", "(", "CPZ", ")", "a", "neuroleptic", "which", "has", "both", "C0178504#ent", "<e2>", "and", "antidopaminergic", "activity", "when", "administered", "in", "doses", "of", "5", "to", "25", "mg/kg", "s.c", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0178504", "name": "C0178504#ent", "pos": [10, 11]}}
{"token": ["It", "is", "therefore", "concluded", "that", ",", "for", "expression", "of", "the", "strong", "adjuvanticity", "of", "C0064378#ent", "<e1>", "both", "the", "lipid", "A", "C0032594#ent", "<e2>", "indispensable", "and", "must", "be", "combined", "in", "the", "form", "of", "LPS", "."], "h": {"id": "C0064378", "name": "C0064378#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [19, 20]}}
{"token": ["Photo-uncaging", "of", "IP3", "in", "neurons", "expressing", "C3714973#ent", "<e1>", "a", "marked", "synaptic", "potentiation", "mimicking", "the", "C1417860#ent", "<e2>", "effect", "."], "h": {"id": "C3714973", "name": "C3714973#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417860", "name": "C1417860#ent", "pos": [14, 15]}}
{"token": ["The", "cultured", "PE", "cells", "expressed", "C3714613#ent", "<e1>", "isoenzyme", ",", "and", "general", "NE", "markers", "including", "neuron", "specific", "C0031691#ent", "<e2>", ",", "and", "amine", "handling", "enzyme", "activity", "the", "range", "of", "SCLC", "cell", "lines", "."], "h": {"id": "C3714613", "name": "C3714613#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031691", "name": "C0031691#ent", "pos": [16, 17]}}
{"token": ["The", "EGR-1", "gene", "an", "immediate", "C0599295#ent", "<e1>", "gene", "encoding", "a", "zinc", "finger", "C1413746#ent", "<e2>"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413746", "name": "C1413746#ent", "pos": [12, 13]}}
{"token": ["The", "disks", "studied", "are", "bare", "C0040412#ent", "<e1>", "glass", "substrates", ",", "having", "different", "groove", "shapes", "differing", "C1416525#ent", "<e2>", "in", "the", "sidewalls", "."], "h": {"id": "C0040412", "name": "C0040412#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416525", "name": "C1416525#ent", "pos": [15, 16]}}
{"token": ["However", ",", "while", "C1705397#ent", "<e1>", "repressor", "activity", "regulated", "by", "C4085201#ent", "<e2>", ",", "Gli2", "repressor", "activity", "is", "not", "."], "h": {"id": "C1705397", "name": "C1705397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4085201", "name": "C4085201#ent", "pos": [9, 10]}}
{"token": ["The", "specific", "binding", "of", "the", "amyloid", "protein", "precursor", "APP", ")", "to", "glycosaminoglycans", "(", "C0017346#ent", "<e1>", ")", "suggests", "that", "APP", "is", "a", "cell", "adhesion", "molecule", "C1537503#ent", "<e2>", ")", "and/or", "substrate", "adhesion", "molecule", "SAM", ")", "."], "h": {"id": "C0017346", "name": "C0017346#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1537503", "name": "C1537503#ent", "pos": [24, 25]}}
{"token": ["The", "antianginal", "effects", "C1882274#ent", "<e1>", ",", "a", "novel", "1,4-dihydropyridine", "derivative", "and", "C0028066#ent", "<e2>", "on", "various", "myocardial", "ischemic", "models", "were", "compared", "."], "h": {"id": "C1882274", "name": "C1882274#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [11, 12]}}
{"token": ["When", "transfected", "into", "COS-7", "cells", "HEK293", "cells", "C1538505#ent", "<e1>", "significantly", "increased", "C2742256#ent", "<e2>", "activity", "."], "h": {"id": "C1538505", "name": "C1538505#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2742256", "name": "C2742256#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "various", "deletion", "plasmids", "that", "the", "1.4-kilobase-pair", "region", "encoding", "C1415119#ent", "<e1>", "necessary", "for", "the", "observed", "regulation", "of", "C0005220#ent", "<e2>", "."], "h": {"id": "C1415119", "name": "C1415119#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [18, 19]}}
{"token": ["This", "interval", "was", "marked", "by", "a", "C3890180#ent", "<e1>", "polymorphism", "and", "a", "C3539751#ent", "<e2>", "microsatellite", "allele", "."], "h": {"id": "C3890180", "name": "C3890180#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539751", "name": "C3539751#ent", "pos": [11, 12]}}
{"token": ["In", "five", "dogs", ",", "C1419345#ent", "<e1>", "plus", "intravenous", "C0016860#ent", "<e2>", "was", "tested", "."], "h": {"id": "C1419345", "name": "C1419345#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [8, 9]}}
{"token": ["1-deamino-8-D-arginine-vasopressin", ",", "or", "DDAVP", ",", "a", "potent", "long", "acting", "antidiuretic", "analogue", "C1706109#ent", "<e1>", ",", "is", "the", "treatment", "of", "choice", "in", "C0011848#ent", "<e2>", "DI", ")", "."], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [20, 21]}}
{"token": ["This", "assay", "was", "optimized", "to", "permit", "the", "identification", "of", "vasopressin", "(", "C1706109#ent", "<e1>", ")", "mRNAs", "containing", "the", "frame-shift", "point", "deletion", "C0011848#ent", "<e2>", "the", "Brattleboro", "strain", "rat", "."], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [20, 21]}}
{"token": ["In", "mutant", "Brattleboro", "rats", ",", "which", "have", "aberrant", "C1706109#ent", "<e1>", ",", "which", "results", "in", "C0011848#ent", "<e2>", "7B2", "appears", "to", "be", "markedly", "decreased", "in", "vasopressinergic", "neurons", "and", "absent", "in", "their", "corresponding", "neurohypophyseal", "terminals"], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [14, 15]}}
{"token": ["C1538267#ent", "<e1>", "and", "TAK", "were", "only", "detectable", "in", "patients", "with", "C0339143#ent", "<e2>", "also", "had", "TSIg", "."], "h": {"id": "C1538267", "name": "C1538267#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [10, 11]}}
{"token": ["Charcot-Marie-Tooth", "(", "CMT", ")", "disease", "is", "a", "clinically", "and", "genetically", "heterogeneous", "group", "of", "inherited", "peripheral", "neuropathies", "by", "progressive", "C3714552#ent", "<e1>", "and", "atrophy", "of", "C1848736#ent", "<e2>"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1848736", "name": "C1848736#ent", "pos": [23, 24]}}
{"token": ["Sequence", "analysis", "the", "fusion", "region", "the", "amplified", "cDNA", "fragment", "an", "in-frame", "joining", "of", "exon", "e5", "of", "the", "MLL", "gene", "position", "1931", "of", "the", "cDNA", "sequence", "the", "C1423947#ent", "<e1>", "giving", "rise", "to", "a", "new", "C3274692#ent", "<e2>", "transcript", "."], "h": {"id": "C1423947", "name": "C1423947#ent", "pos": [26, 27]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274692", "name": "C3274692#ent", "pos": [33, 34]}}
{"token": ["H69/Txl", "showed", "higher", "sensitivity", "to", "C0042672#ent", "<e1>", "as", "vindesine", ",", "C0042679#ent", "<e2>", "and", "vinblastine", "than", "the", "parental", "H69", "."], "h": {"id": "C0042672", "name": "C0042672#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [10, 11]}}
{"token": ["The", "optimum", "experimental", "conditions", "been", "investigated", "for", "the", "measurement", "of", "the", "birth-rate", "in", "human", "psoriatic", "epidermis", "the", "C0042672#ent", "<e1>", "vinblastine", "and", "C0042679#ent", "<e2>", "."], "h": {"id": "C0042672", "name": "C0042672#ent", "pos": [17, 18]}, "relation": "structural_class_of", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [21, 22]}}
{"token": ["Animals", "with", "spontaneous", "seizures", "showed", "increased", "inhibition", "in", "the", "dentate", "gyrus", "a", "characteristic", "of", "the", "C0014544#ent", "<e1>", "with", "evidence", "of", "C1280469#ent", "<e2>", "fiber", "synaptic", "reorganization"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1280469", "name": "C1280469#ent", "pos": [20, 21]}}
{"token": ["In", "C0014544#ent", "<e1>", "rats", ",", "sprouted", "C1280469#ent", "<e2>", "fiber", "synaptic", "terminals", "frequently", "observed", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1280469", "name": "C1280469#ent", "pos": [6, 7]}}
{"token": ["In", "the", "presence", "of", "BIBP", "3226", "an", "C1516869#ent", "<e1>", "binds", "selectively", "to", "C1705518#ent", "<e2>", "Y1-receptors", ",", "the", "effect", "of", "C1705518#ent", "<e2>", "on", "4-AP", "I(to", ")", "density", "was", "maintained", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705518", "name": "C1705518#ent", "pos": [12, 13]}}
{"token": ["Biochemical", "markers", "gene", "systems", "Alb", ",", "C1333522#ent", "<e1>", ",", "Gc", ",", "Hp", ",", "C1415104#ent", "<e2>", ",", "PGM1", ",", "EsD", ",", "AcP", "were", "analysed", "in", "the", "native", "population", "of", "Evenc", "national", "region", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415104", "name": "C1415104#ent", "pos": [13, 14]}}
{"token": ["Subjects", "with", "congenital", "deficiency", "protein", "S", "a", "natural", "anticoagulant", "serves", "as", "a", "C0003438#ent", "<e1>", "for", "the", "antithrombotic", "activity", "C1170000#ent", "<e2>", "are", "at", "risk", "of", "thrombosis", "."], "h": {"id": "C0003438", "name": "C0003438#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1170000", "name": "C1170000#ent", "pos": [18, 19]}}
{"token": ["These", "C0233762#ent", "<e1>", "visual", "disturbances", "shortly", "after", "her", "regimen", "was", "changed", "from", "C0700482#ent", "<e2>", "10", "mg/day", "to", "70", "mg", "once/week", "."], "h": {"id": "C0233762", "name": "C0233762#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0700482", "name": "C0700482#ent", "pos": [12, 13]}}
{"token": ["liminatans", "reacted", "only", "with", "the", "C1512488#ent", "<e1>", "enzyme", "and", "did", "not", "form", "precipitates", "with", "C4283758#ent", "<e2>", "ADHs", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4283758", "name": "C4283758#ent", "pos": [14, 15]}}
{"token": ["However", ",", "we", "could", "not", "confirm", "previous", "reports", "that", "C0032143#ent", "<e1>", "production", "was", "enhanced", "by", "C0220914#ent", "<e2>", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220914", "name": "C0220914#ent", "pos": [15, 16]}}
{"token": ["Simultaneous", "inactivation", "of", "CYP2C8", "and", "C1142644#ent", "<e1>", "(", "paclitaxel", "3'-phenyl-hydroxylation", ")", "was", "observed", "using", "C0002598#ent", "<e2>", ",", "isoniazid", ",", "and", "phenelzine", "with", "the", "efficiency", "of", "inactivation", "greater", "for", "the", "CYP3A4", "pathway", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0002598", "name": "C0002598#ent", "pos": [14, 15]}}
{"token": ["Platelet", "activating", "factor", "C0235480#ent", "<e1>", ")", "content", "and", "PAF-acetylhydrolase", "(", "C1418625#ent", "<e2>", ")", "activity", "were", "measured", "in", "the", "plasma", "and", "haematoma", "of", "34", "chronic", "subdural", "haematoma", "CSH", ")", "patients", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418625", "name": "C1418625#ent", "pos": [10, 11]}}
{"token": ["The", "C0026916#ent", "<e1>", "MAC", ")", "is", "an", "important", "cause", "of", "C0149642#ent", "<e2>", "children", ",", "and", "its", "incidence", "appears", "to", "be", "increasing", "in", "the", "United", "States", "elsewhere", "."], "h": {"id": "C0026916", "name": "C0026916#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0149642", "name": "C0149642#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "partial", "muscarinic", "agonist", "pilocarpine", "on", "physiological", "responses", "investigated", "in", "rat", "pancreatic", "acinar", "cells", "compared", "with", "carbachol", ",", "a", "full", "C3536929#ent", "<e1>", "together", "with", "previous", "results", "using", "JMV-180", ",", "a", "partial", "C0243192#ent", "<e2>", "of", "CCK-A", "receptors"], "h": {"id": "C3536929", "name": "C3536929#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [33, 34]}}
{"token": ["Intrauterine", "exposure", "to", "C0011849#ent", "<e1>", "and", "size", "at", "birth", "are", "risk", "factors", "C0011854#ent", "<e2>", "but", "their", "association", "with", "MS", "in", "childhood", "has", "not", "been", "demonstrated", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "HSA-mediated", "mechanism", "involved", "in", "the", "in", "vitro", "hydrolysis", "by", "C1412332#ent", "<e1>", "of", "the", "acyl", "glucuronides", "(R)-", "and", "(S)-ketoprofen", "(", "a", "C0003211#ent", "<e2>", ",", "as", "model", "compounds"], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [29, 30]}}
{"token": ["We", "hypothesized", "that", "reactive", "oxygen", "species", "C0289313#ent", "<e1>", ")", "may", "be", "involved", "in", "the", "pathogenesis", "of", "C0037116#ent", "<e2>", "."], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037116", "name": "C0037116#ent", "pos": [16, 17]}}
{"token": ["C0025029#ent", "<e1>", "blocked", "rat", "alpha7", "receptors", "if", "co-administered", "with", "C2987634#ent", "<e2>", ",", "but", "much", "more", "potently", "when", "pre-applied", "."], "h": {"id": "C0025029", "name": "C0025029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [9, 10]}}
{"token": ["C0025029#ent", "<e1>", "attenuated", "the", "locomotor", "depressant", "effects", "of", "most", "of", "the", "C2987634#ent", "<e2>", ",", "except", "lobeline", "."], "h": {"id": "C0025029", "name": "C0025029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}}
{"token": ["This", "current", "was", "blocked", "by", "either", "the", "ACh", "channel", "blocker", "C0025029#ent", "<e1>", "or", "the", "receptor", "blocker", "dihydro-beta-erythroidine", "indicating", "that", "butanol", "activated", "receptors", "a", "partial", "C2987634#ent", "<e2>", "."], "h": {"id": "C0025029", "name": "C0025029#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [24, 25]}}
{"token": ["C1426677#ent", "<e1>", "and", "RV", "influence", "C1426033#ent", "<e2>", "levels", "independently", "and", "large", "inter-patient", "differences", "are", "well", "characterized", "by", "SD", "values", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1426033", "name": "C1426033#ent", "pos": [5, 6]}}
{"token": ["While", "C0149931#ent", "<e1>", "appears", "not", "to", "be", "associated", "with", "coronary", "heart", "disease", "preliminary", "evidence", "suggests", "a", "possible", "link", "of", "C0149931#ent", "<e1>", "with", "vasospastic", "disorders", "such", "as", "variant", "angina", "C0151445#ent", "<e1>", "phenomenon", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0151445", "name": "C0151445#ent", "pos": [28, 29]}}
{"token": ["Hepatic", "C2717971#ent", "<e1>", "including", "plasminogen", "activator", "and", "C0029282#ent", "<e2>", "ODC", ")", "are", "induced", "by", "the", "hepatotoxin", "galactosamine", "GALN", ")", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [7, 8]}}
{"token": ["To", "correlate", "PAI", "levels", "to", "patency", "of", "infarct", "arteries", "thrombolytic", "therapy", "C0032143#ent", "<e1>", "rt-PA", ")", ",", "125", "consecutive", "patients", "with", "C0027051#ent", "<e2>", "were", "examined", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [20, 21]}}
{"token": ["Activation", "of", "transcription", "requires", "corepressor", "displacement", "C1413754#ent", "<e1>", "by", "NotchIC", "and", "the", "recruitment", "of", "the", "C1422120#ent", "<e2>", "the", "complex", "."], "h": {"id": "C1413754", "name": "C1413754#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422120", "name": "C1422120#ent", "pos": [15, 16]}}
{"token": ["Finally", ",", "we", "show", "that", "transcriptional", "inhibition", "C0019163#ent", "<e1>", "is", "associated", "with", "changes", "in", "C1420131#ent", "<e2>", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420131", "name": "C1420131#ent", "pos": [14, 15]}}
{"token": ["C0019163#ent", "<e1>", "transcription", "control", "elements", "display", "a", "preference", "for", "C1420131#ent", "<e2>", "or", "liver-enriched", "trans-factors", ",", "which", "contributes", "to", "the", "liver", "tropism", "the", "virus", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420131", "name": "C1420131#ent", "pos": [9, 10]}}
{"token": ["Hepatitis", "B", "virus", "C0019163#ent", "<e1>", ")", "ENI", "enhancer", "can", "activate", "the", "expression", "of", "C0019163#ent", "<e1>", "and", "non-HBV", "genes", "in", "a", "C1420131#ent", "<e1>"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420131", "name": "C1420131#ent", "pos": [20, 21]}}
{"token": ["A", "large", "inverted", "repeat", "that", "may", "function", "as", "a", "rho-independent", "transcriptional", "terminator", "was", "located", "between", "C1415782#ent", "<e1>", "and", "the", "third", "C0079941#ent", "<e2>", "."], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [20, 21]}}
{"token": ["There", "was", "no", "association", "between", "the", "presence", "of", "C1706112#ent", "<e1>", "s", "and", "reduced", "C1414083#ent", "<e2>", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [13, 14]}}
{"token": ["We", "have", "C1516876#ent", "<e1>", "analyzed", "a", "family", "with", "a", "history", "of", "usual", "C0206061#ent", "<e2>"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [12, 13]}}
{"token": ["Halcinoide", "was", "found", "to", "be", "superior", "in", "the", "treatment", "of", "psoriasis", "and", "equally", "effective", "as", "C0750848#ent", "<e1>", "the", "treatment", "of", "C0011615#ent", "<e2>"], "h": {"id": "C0750848", "name": "C0750848#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [20, 21]}}
{"token": ["The", "use", "of", "a", "glutathione", "redox", "buffer", "coupled", "with", "the", "C0072354#ent", "<e1>", "pH", "optimization", "produced", "40", "microg/mL", "of", "C0042071#ent", "<e2>", "a", "simple", "batch", "reaction"], "h": {"id": "C0072354", "name": "C0072354#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [18, 19]}}
{"token": ["C0079856#ent", "<e1>", ",", "a", "new", "C0003195#ent", "<e2>", "has", "been", "undergoing", "clinical", "trials", "over", "13", "years", "in", "the", "United", "States"], "h": {"id": "C0079856", "name": "C0079856#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [5, 6]}}
{"token": ["C0079856#ent", "<e1>", "therapeutic", "dosages", "10", "mg/kg", "daily", ")", "demonstrated", "C0003195#ent", "<e2>", "significant", "alterations", "in", "serum", "digoxin", "levels", "."], "h": {"id": "C0079856", "name": "C0079856#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [9, 10]}}
{"token": ["C0079856#ent", "<e1>", "a", "new", "C0003195#ent", "<e2>", "tested", "in", "a", "open", "crossover", "study", "a", "group", "of", "46", "patients", "with", "more", "than", "2500", "ventricular", "extrasystoles", "24", "hours", "or", "with", "ventricular", "arrhythmias", "III", "a", "higher", "Lown", "class", "."], "h": {"id": "C0079856", "name": "C0079856#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [4, 5]}}
{"token": ["Furthermore", ",", "distinct", "C2713509#ent", "<e1>", "abrogated", "the", "protective", "effect", "C1333928#ent", "<e2>", "expression", "on", "Akt", "activation", ",", "Bax", "inactivation", ",", "and", "cell", "survival"], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333928", "name": "C1333928#ent", "pos": [9, 10]}}
{"token": ["Proteinase", "3", "C1427831#ent", "<e1>", ")", "is", "a", "C2717971#ent", "<e2>", "in", "the", "primary", "granules", "neutrophils", "."], "h": {"id": "C1427831", "name": "C1427831#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [7, 8]}}
{"token": ["We", "report", "the", "case", "of", "a", "59-year-old", "woman", "suffering", "from", "profound", "accidental", "hypothermia", "promoted", "by", "intoxication", "with", "codeine", ",", "C0020592#ent", "<e1>", ",", "and", "a", "C0304516#ent", "<e2>", "ingested", "in", "a", "suicidal", "attempt"], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [24, 25]}}
{"token": ["An", "angiotensin", "AT1", "receptor", "antagonist", "losartan", ",", "but", "not", "a", "Ca2", "+", "channel", "blocker", "verapamil", ",", "inhibited", "the", "development", "of", "C0027726#ent", "<e1>", "while", "both", "C0991617#ent", "<e2>", "decreased", "blood", "pressure", "a", "similar", "extent", "as", "imidapril", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [24, 25]}}
{"token": ["The", "cardiac", "(", "myofibrillar", "loss", "dilatation", "of", "the", "sarcoplasmic", "reticulum", "and", "renal", "(", "glomerular", "vacuolization", "tubular", "damage", "laboratory", "evidence", "of", "a", "C0027726#ent", "<e1>", "lesions", "induced", "by", "all", "three", "C0991617#ent", "<e2>", "had", "similar", "features", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [28, 29]}}
{"token": ["This", "study", "was", "designed", "to", "investigate", "the", "effects", "of", "NO", "and", "milrinone", "on", "RV", "diastolic", "dysfunction", "the", "setting", "of", "C0054757#ent", "<e1>", "and", "RV", "hypertrophy", "use", "of", "a", "canine", "model", "of", "C0066739#ent", "<e2>", "C0054757#ent", "<e1>", "."], "h": {"id": "C0054757", "name": "C0054757#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0066739", "name": "C0066739#ent", "pos": [30, 31]}}
{"token": ["Both", "Northern", "blot", "analysis", "C0035379#ent", "<e1>", "in", "situ", "PCR", "RT-in", "situ", "PCR", ")", "studies", "demonstrated", "that", "inducible", "NO", "synthase", "C1417760#ent", "<e2>", ")", "mRNA", "was", "present", "in", "the", "brain", "tissues", "MS", "patients", "but", "was", "absent", "in", "equivalent", "tissues", "from", "normal", "controls"], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", "we", "compared", "the", "pharmacological", "characteristics", "of", "a", "new", "5-HT(2", ")", "antagonist", "C0286592#ent", "<e1>", "and", "its", "active", "metabolite", "with", "those", "of", "C1517662#ent", "<e2>", "on", "human", "recombinant", "alpha(1)-AR", "subtypes", "."], "h": {"id": "C0286592", "name": "C0286592#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [24, 25]}}
{"token": ["Highest", "risk", "C0003211#ent", "<e1>", "azapropazone", ",", "ketoprofen", "and", "C0031990#ent", "<e2>", ",", "and", "those", "with", "least", "risk", "include", "ibuprofen", ",", "diclofenac", "and", "etodolac", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [2, 3]}, "relation": "structural_class_of", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [8, 9]}}
{"token": ["More", "than", "90", "%", "of", "vesicles", "associated", "with", "C1420117#ent", "<e1>", "also", "contained", "C1416639#ent", "<e2>", ",", "and", "inhibition", "of", "C1420117#ent", "<e1>", "with", "antibody", "resulted", "in", "enhancement", "of", "plus-end-directed", "motility"], "h": {"id": "C1416639", "name": "C1416639#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420117", "name": "C1420117#ent", "pos": [8, 9]}}
{"token": ["We", "compared", "the", "standard", "C0074554#ent", "<e1>", "plus", "C2917337#ent", "<e2>", "cholestyramine", ")", "therapy", "with", "C0074554#ent", "<e1>", "plus", "fenofibrate", "in", "29", "patients", "with", "severe", "familial", "hypercholesterolaemia"], "h": {"id": "C2917337", "name": "C2917337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0074554", "name": "C0074554#ent", "pos": [4, 5]}}
{"token": ["The", "most", "effective", "regimens", "have", "used", "C2917337#ent", "<e1>", "combination", "with", "nicotinic", "acid", "or", "more", "recently", ",", "lovastatin", "or", "C0074554#ent", "<e2>", "."], "h": {"id": "C2917337", "name": "C2917337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0074554", "name": "C0074554#ent", "pos": [18, 19]}}
{"token": ["Thiobarbituric", "acid-reactive", "substances", "TBARS", ")", "level", ",", "as", "marker", "of", "lipid", "peroxidation", "and", "superoxide", "dismutase", "C1704945#ent", "<e1>", ")", "activity", ",", "as", "endogenous", "C1424792#ent", "<e2>", "were", "examined", "in", "liver", "and", "soleus", "muscle", "of", "young", "and", "old", "male", "Wistar", "rats"], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1424792", "name": "C1424792#ent", "pos": [22, 23]}}
{"token": ["Concentrations", "of", "dihomogammalinolenic", "acid", "20:3", "omega", "6", ")", "were", "low", "in", "C0020758#ent", "<e1>", ",", "normal", "in", "C0702166#ent", "<e2>", "and", "elevated", "in", "psoriasis", "."], "h": {"id": "C0020758", "name": "C0020758#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0702166", "name": "C0702166#ent", "pos": [16, 17]}}
{"token": ["The", "clinical", "picture", "AIED", "includes", "myopia", "and", "C0004106#ent", "<e1>", ",", "reduced", "visual", "acuity", "nystagmus", ",", "ocular", "albinism", "hemeralopia", "and", "C0858618#ent", "<e2>", "(", "No.", "300600", ",", "McKusick", "1990", ")", "."], "h": {"id": "C0004106", "name": "C0004106#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0858618", "name": "C0858618#ent", "pos": [19, 20]}}
{"token": ["The", "findings", "indicate", "different", "developmental", "pathways", "\"", "pure", "'", "C1418543#ent", "<e1>", "children", "and", "those", "with", "comorbid", "C2740858#ent", "<e2>", "."], "h": {"id": "C1418543", "name": "C1418543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2740858", "name": "C2740858#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "are", "discussed", "in", "relation", "to", "the", "positive", "Kveim", "responses", "previously", "reported", "among", "patients", "with", "C0156147#ent", "<e1>", "tuberculoid", "and", "C0023348#ent", "<e2>", "and", "among", "seemingly", "healthy", "BCG", "vaccinated", "subjects", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023348", "name": "C0023348#ent", "pos": [20, 21]}}
{"token": ["Using", "fibronectin", "as", "a", "C0072522#ent", "<e1>", "we", "have", "explored", "the", "effect", "of", "C1519648#ent", "<e2>", "upon", "oligosaccharide", "structure", "glycoprotein", "synthesis", "and", "secretion", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1519648", "name": "C1519648#ent", "pos": [12, 13]}}
{"token": ["Accordingly", ",", "C0072522#ent", "<e1>", "be", "produced", "in", "the", "presence", "of", "C1519648#ent", "<e2>", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1519648", "name": "C1519648#ent", "pos": [10, 11]}}
{"token": ["To", "delineate", "the", "potential", "role", "of", "C1257958#ent", "<e1>", "glucose-precursor", "kinetics", "in", "the", "abnormal", "carbohydrate", "metabolism", "C0022661#ent", "<e2>", "alanine", "and", "glucose", "production", "utilization", "and", "gluconeogenesis", "from", "alanine", "were", "studied", "in", "patients", "with", "chronic", "compensated", "renal", "insufficiency", "in", "normal", "volunteers"], "h": {"id": "C1257958", "name": "C1257958#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [15, 16]}}
{"token": ["These", "transfectants", "expressed", "high-affinity", "IL-2R", "and", "internalized", "C0879590#ent", "<e1>", "at", "a", "rate", "comparable", "to", "cells", "expressing", "wild-type", "C0544483#ent", "<e2>", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0544483", "name": "C0544483#ent", "pos": [17, 18]}}
{"token": ["Under", "halothane", ",", "the", "C0024591#ent", "<e1>", "animals", "had", "significantly", "augmented", "dantrolene", "response", "compared", "to", "MHR", "pigs", ",", "but", "three", "C0024591#ent", "<e1>", "animals", "had", "developed", "the", "MH", "syndrome", "to", "receiving", "C0010977#ent", "<e1>", "."], "h": {"id": "C0024591", "name": "C0024591#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0010977", "name": "C0010977#ent", "pos": [29, 30]}}
{"token": ["HNF-4", "is", "an", "orphan", "nuclear", "receptor", "is", "constitutively", "expressed", "in", "kidney", "and", "C0023899#ent", "<e1>", "and", "which", "cooperates", "with", "C1958958#ent", "<e2>", "to", "give", "maximal", "hypoxic", "induction", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1958958", "name": "C1958958#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "changes", "in", "C2975867#ent", "<e1>", "have", "been", "recognized", "as", "an", "important", "cellular", "signal", "determine", "the", "C1539479#ent", "<e2>", "of", "cells", "in", "terms", "of", "proliferation", "or", "apoptosis", "."], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [17, 18]}}
{"token": ["The", "enzyme", "shows", "a", "broad", "specificity", "for", "C0001109#ent", "<e1>", "especially", "in", "the", "presence", "of", "C1706611#ent", "<e2>", ",", "and", "thus", "resembles", "closely", "nucleoside", "diphosphate", "kinase"], "h": {"id": "C0001109", "name": "C0001109#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706611", "name": "C1706611#ent", "pos": [14, 15]}}
{"token": ["These", "data", "support", "the", "hypothesis", "that", "tracheal", "C0017082#ent", "<e1>", "are", "intimately", "involved", "in", "the", "development", "of", "C0004096#ent", "<e2>"], "h": {"id": "C0017082", "name": "C0017082#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["Within", "3", "hours", "of", "bacterial", "inoculation", ",", "all", "lambs", "that", "received", "P", "haemolytica", "were", "C0003620#ent", "<e1>", ",", "listless", ",", "and", "C0015967#ent", "<e2>", ",", "and", "had", "hyperpnea", "and", "dyspnea", "."], "h": {"id": "C0003620", "name": "C0003620#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [20, 21]}}
{"token": ["A", "female", "Dorset-cross", "sheep", "developed", "labored", "respirations", "was", "C0003620#ent", "<e1>", ",", "weak", ",", "ataxic", "and", "C0015967#ent", "<e2>", "(", "42.0", "degrees", "C", ")", "15", "days", "after", "implantation", "of", "a", "cardiac", "device"], "h": {"id": "C0003620", "name": "C0003620#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [15, 16]}}
{"token": ["All", "had", "been", "treated", "with", "range", "of", "antiretroviral", "therapy", "only", "two", "had", "had", "acquired", "C0021051#ent", "<e1>", "AIDS", ")", "defining", "C0679247#ent", "<e2>", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0679247", "name": "C0679247#ent", "pos": [19, 20]}}
{"token": ["High", "homology", "with", "the", "C1418975#ent", "<e1>", "found", "in", "a", "region", "beginning", "67", "bp", "before", "the", "C0079941#ent", "<e2>", "and", "proceeding", "546", "bp", "into", "the", "C0079941#ent", "<e2>", "."], "h": {"id": "C1418975", "name": "C1418975#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}}
{"token": ["Although", "BDNF", "increased", "C3539803#ent", "<e1>", "RSK", ")", "phosphorylation", ",", "C0022614#ent", "<e2>", "had", "no", "discernable", "effect", "on", "the", "phosphorylation", "of", "RSKs", "."], "h": {"id": "C3539803", "name": "C3539803#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [9, 10]}}
{"token": ["Although", "both", "C0031727#ent", "<e1>", "participate", "in", "regulating", "cell", "growth", "there", "was", "no", "detectable", "activation", "of", "C2827383#ent", "<e2>", "TPA-", "or", "okadaic", "acid-induced", "monocytic", "differentiation", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "femoral", "muscle", "pain", "and", "a", "high", "level", "of", "serum", "GOT", ",", "GPT", ",", "C1872855#ent", "<e1>", ",", "Aldolase", "and", "Myoglobin", "indicated", "hepatitis", "and", "C0027121#ent", "<e2>", "."], "h": {"id": "C1872855", "name": "C1872855#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027121", "name": "C0027121#ent", "pos": [25, 26]}}
{"token": ["The", "C0162644#ent", "<e1>", "isolated", "with", "nail", "polish", "teeth", "were", "immersed", "in", "C1161347#ent", "<e2>"], "h": {"id": "C0162644", "name": "C0162644#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1161347", "name": "C1161347#ent", "pos": [11, 12]}}
{"token": ["AAF2", "was", "found", "to", "preferentially", "bind", "to", "the", "C1421476#ent", "<e1>", "GAS", ",", "but", "not", "at", "all", "to", "the", "C3539609#ent", "<e2>", "GAS", ",", "and", "contained", "no", "ISGF3", "protein"], "h": {"id": "C1421476", "name": "C1421476#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539609", "name": "C3539609#ent", "pos": [18, 19]}}
{"token": ["This", "requires", "the", "activities", "of", "Sgs1", ",", "a", "member", "of", "the", "C1335669#ent", "<e1>", "DNA", "helicases", "and", "the", "ATM-related", "kinase", "Mec1", ",", "but", "not", "C1424448#ent", "<e2>", "activation", "."], "h": {"id": "C1335669", "name": "C1335669#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1424448", "name": "C1424448#ent", "pos": [23, 24]}}
{"token": ["Rats", "were", "given", "either", "tap", "water", "water", "medicated", "lisinopril", ",", "C0287041#ent", "<e1>", "or", "both", "C0991617#ent", "<e2>", "in", "combination", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [14, 15]}}
{"token": ["Within", "the", "class", "of", "angiotensin", "II", "antagonists", "C0287041#ent", "<e1>", "differs", "from", "other", "currently", "clinically", "available", "C0991617#ent", "<e2>", "in", "terms", "of", "its", "chemical", "structure", "its", "dual", "pharmacological", "mode", "of", "action", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [15, 16]}}
{"token": ["Separate", "groups", "of", "urethane-anesthetized", "Sprague-Dawley", "rats", "graded", "doses", "of", "the", "EAA", "receptor", "agonists", "L-Glu", ",", "NMDA", ",", "C0022471#ent", "<e1>", "alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic", "acid", "microinjected", "into", "the", "C1417869#ent", "<e2>", "before", "and", "after", "systemic", "administration", "ethanol", "(", "1", "g/kg", ")", "."], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [24, 25]}}
{"token": ["A", "combination", "of", "bioinformatics", "analysis", "C0014442#ent", "<e1>", "kinetics", "and", "substrate-specificity", "characterization", "revealed", "that", "C4049880#ent", "<e2>", "exhibits", "both", "dual-specificity", "protein", "phosphatase", "and", ",", "importantly", ",", "phosphoinositide", "phosphatase", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4049880", "name": "C4049880#ent", "pos": [13, 14]}}
{"token": ["The", "hyper-IgD", "and", "periodic", "fever", "syndrome", "C0398691#ent", "<e1>", ")", "is", "characterized", "by", "recurrent", "attacks", "fever", ",", "abdominal", "distress", "and", "C0003862#ent", "<e2>", "and", "is", "caused", "by", "mevalonate", "kinase", "mutations"], "h": {"id": "C0398691", "name": "C0398691#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [19, 20]}}
{"token": ["Our", "findings", ",", "thus", ",", "strongly", "suggest", "that", "the", "inhibition", "of", "C1334899#ent", "<e1>", "cells", "expressing", "the", "C0069518#ent", "<e2>", "mediated", "by", "Fos", "."], "h": {"id": "C1334899", "name": "C1334899#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0069518", "name": "C0069518#ent", "pos": [16, 17]}}
{"token": ["Oxotremorine", ",", "a", "C3536929#ent", "<e1>", "preferentially", "stimulated", "C1416378#ent", "<e2>", ",", "cAMP", "inhibition", "(", "EC50", "=", "15.8", "+", "/-", "1.4", "microM", ")", ",", "whilst", "Fin", "was", "only", "weakly", "activated", "."], "h": {"id": "C3536929", "name": "C3536929#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416378", "name": "C1416378#ent", "pos": [7, 8]}}
{"token": ["The", "interactions", "between", "human", "C1416958#ent", "<e1>", "(", "hsMAD1", ")", "and", "human", "C1708842#ent", "<e2>", "(", "hsMAD2", ")", "have", ",", "however", ",", "remained", "poorly", "characterized", "."], "h": {"id": "C1416958", "name": "C1416958#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1708842", "name": "C1708842#ent", "pos": [11, 12]}}
{"token": ["The", "differential", "diagnosis", "systemic", "lupus", "erythematosus", "sarcoidosis", ",", "C0023283#ent", "<e1>", "other", "skin", "diseases", "tertiary", "syphilis", "lymphomas", ",", "C0553576#ent", "<e2>", "traumatic", "lesions", "and", "malignant", "neoplasias", "among", "other", "disorders", "."], "h": {"id": "C0023283", "name": "C0023283#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0553576", "name": "C0553576#ent", "pos": [17, 18]}}
{"token": ["To", "explore", "cardiac", "and", "renal", "potential", "protective", "effects", "C1416670#ent", "<e1>", "in", "chronic", "renal", "failure", "we", "delivered", "adenovirus", "carrying", "the", "human", "C0076726#ent", "<e2>", "cHK", ")", "into", "rats", "with", "5/6", "reduction", "of", "renal", "mass"], "h": {"id": "C1416670", "name": "C1416670#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0076726", "name": "C0076726#ent", "pos": [20, 21]}}
{"token": ["ATPA", "and", "ABPA", ",", "in", "which", "the", "methyl", "group", "C1704949#ent", "<e1>", "was", "replaced", "by", "more", "bulky", "substituents", ",", "were", "also", "C1705603#ent", "<e2>", "agonists", ",", "although", "weaker", "than", "C1704949#ent", "<e1>", "."], "h": {"id": "C1705603", "name": "C1705603#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [9, 10]}}
{"token": ["Expression", "of", "transgenes", "comprised", "of", "C2826549#ent", "<e1>", "promoter", "fragments", "to", "chloramphenicol", "C0001068#ent", "<e2>", "differentiating", "brown", "adipocytes", "revealed", "that", "a", "known", "nuclear", "receptor", "response", "element", "NRRE-1", ")", "was", "required", "for", "the", "transcriptional", "induction", "the", "C2826549#ent", "<e1>", "brown", "adipocyte", "differentiation", "."], "h": {"id": "C2826549", "name": "C2826549#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001068", "name": "C0001068#ent", "pos": [11, 12]}}
{"token": ["Data", "show", "that", "C0950123#ent", "<e1>", "mutations", "in", "cancer-predisposing", "genes", "such", "as", "C0376571#ent", "<e2>", "and", "BRCA2", ",", "markedly", "increase", "the", "risk", "of", "cancers", "at", "unusually", "early", "ages"], "h": {"id": "C0950123", "name": "C0950123#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0376571", "name": "C0376571#ent", "pos": [11, 12]}}
{"token": ["The", "region", "of", "Tac25", "hybridizing", "to", "C1417072#ent", "<e1>", "was", "sequenced", "and", "shown", "to", "contain", "an", "C0079941#ent", "<e2>", "ORF", ")", "with", "homology", "to", "actin", "."], "h": {"id": "C1417072", "name": "C1417072#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}}
{"token": ["Bioinformatic", "searches", "the", "sea", "urchin", "genome", "database", "C4277608#ent", "<e1>", "of", "Drosha", ",", "DGCR5", ",", "C1333218#ent", "<e2>", ",", "TRBP", ",", "Exportin-5", ",", "and", "Argonautes", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333218", "name": "C1333218#ent", "pos": [14, 15]}}
{"token": ["By", "contrast", ",", "indomethacin", "improved", "body", "composition", "in", "C1419061#ent", "<e1>", "and", "EP3", "knockouts", "as", "well", "as", "in", "C1883559#ent", "<e2>", "animals", "and", "tumor", "growth", "retarded", "in", "C1419061#ent", "<e1>", "and", "promoted", "in", "EP3", "knock", "outs", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419061", "name": "C1419061#ent", "pos": [8, 9]}}
{"token": ["present", "in", "the", "plant", "and", "by", "assessing", "the", "C1512412#ent", "<e1>", "efficacy", "of", "the", "plant", "against", "lead", "C0000975#ent", "<e2>", "induced", "albino", "rats", "."], "h": {"id": "C1512412", "name": "C1512412#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [16, 17]}}
{"token": ["There", "is", "a", "wide", "clinical", "spectrum", "with", "approximately", "one-third", "of", "patients", "with", "C0751357#ent", "<e1>", "developing", "polymyositis", ",", "and", "clinical", "symptoms", "C0746674#ent", "<e2>", "fever", ",", "myalgia", ",", "and", "weight", "loss", "with", "elevation", "of", "creatine", "phosphokinase"], "h": {"id": "C0751357", "name": "C0751357#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0746674", "name": "C0746674#ent", "pos": [20, 21]}}
{"token": ["IGF-I", "treatment", "for", "unequivocal", "GH", "insensitivity", "improves", "but", "does", "not", "correct", "C0878787#ent", "<e1>", "in", "contrast", "to", "the", "typical", "experience", "with", "GH", "replacement", "C0013338#ent", "<e2>"], "h": {"id": "C0878787", "name": "C0878787#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013338", "name": "C0013338#ent", "pos": [22, 23]}}
{"token": ["Moderate", "C0020437#ent", "<e1>", "occurred", "in", "a", "17-year-old", "male", "who", "was", "C2350558#ent", "<e2>", "with", "abdominal", "and", "right", "hip", "sepsis", "for", "9", "months", "after", "a", "motor", "vehicle", "accident", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [10, 11]}}
{"token": ["mRNAs", "related", "to", "SC", "function", ",", "including", "myelin-specific", "genes", ",", "were", "increased", "by", "C1704690#ent", "<e1>", "treatment", "of", "DRG", "cells", ",", "or", "of", "purified", "C1421244#ent", "<e2>", "isolated", "from", "rat", "sciatic", "nerve"], "h": {"id": "C1704690", "name": "C1704690#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1421244", "name": "C1421244#ent", "pos": [23, 24]}}
{"token": ["Several", "transfectant", "lines", "of", "HepG2", "have", "been", "constructed", "which", "express", "increased", "levels", "of", "phase", "I", "C0014442#ent", "<e1>", "(", "such", "as", "C0059735#ent", "<e2>", ",", "CYP1A2", ",", "CYP2E1", "etc", ".", ")", ";"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [20, 21]}}
{"token": ["This", "report", "describes", "the", "crystal", "structure", "specificity", "of", "a", "novel", "activating", "C0014442#ent", "<e1>", "for", "valacyclovir", "and", "C0909381#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0909381", "name": "C0909381#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "we", "show", "that", "furosemide", "actions", "on", "C1414919#ent", "<e1>", "of", "rat", "substantia", "nigra", "dopaminergic", "neurones", "on", "both", "furosemide", "and", "GABA(A)R", "C0243192#ent", "<e2>", "concentrations", "."], "h": {"id": "C1414919", "name": "C1414919#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [21, 22]}}
{"token": ["l-Lysine", ",", "C0073830#ent", "<e1>", ",", "and", "l-alpha-(2-aminoethoxyvinyl)glycine", "are", "strong", "C0003015#ent", "<e2>", "the", "enzyme", "with", "50", "%", "inhibitory", "values", "of", "20", ",", "160", ",", "and", "155", "millimolar", ",", "respectively", "."], "h": {"id": "C0073830", "name": "C0073830#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [9, 10]}}
{"token": ["No", "correlation", "could", "be", "demonstrated", "between", "C0011849#ent", "<e1>", "duration", "and", "GAGS", ",", "SA", ",", "C1417593#ent", "<e2>", "and", "GAL", "findings", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417593", "name": "C1417593#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", "with", "white", "patients", "complete", "C3280642#ent", "<e1>", "relatively", "infrequently", "in", "black", "patients", "with", "C0024141#ent", "<e2>", "."], "h": {"id": "C3280642", "name": "C3280642#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [14, 15]}}
{"token": ["This", "case", ",", "as", "some", "others", "previously", "published", ",", "outlines", "the", "possibility", "of", "the", "association", "of", "C0020807#ent", "<e1>", "C0003873#ent", "<e2>", "is", "this", "a", "casual", "association", "or", "may", "C0020807#ent", "<e1>", "a", "rare", "manifestation", "of", "C0003873#ent", "<e2>"], "h": {"id": "C0020807", "name": "C0020807#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [18, 19]}}
{"token": ["SIPK-mediated", "enhancement", "of", "WRKY1", "C0812382#ent", "<e1>", "inhibited", "by", "C0075193#ent", "<e2>", ",", "a", "general", "kinase", "inhibitor"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [8, 9]}}
{"token": ["The", "authors", "performed", "a", "24-hour", "polysomnography", "C1418997#ent", "<e1>", ")", "in", "a", "PD", "patient", "taking", "C0031008#ent", "<e2>", "in", "combination", "with", "levodopa", ",", "in", "which", "four", "of", "these", "diurnal", "sleep", "occurred", "."], "h": {"id": "C1418997", "name": "C1418997#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031008", "name": "C0031008#ent", "pos": [14, 15]}}
{"token": ["The", "first", "patient", "had", "a", "chronic", "lithium", "intoxication", "with", "cerebellar", "signs", "eventually", "coma", ",", "diabetes", "insipidus", "C3831153#ent", "<e1>", ",", "hyperparathyroidism", "and", "C1419789#ent", "<e2>", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [21, 22]}}
{"token": ["Because", "of", "the", "absence", "of", "polymorphisms", ",", "however", ",", "C1413240#ent", "<e1>", "is", "unlikely", "to", "affect", "the", "progression", "of", "C0019189#ent", "<e2>", "terms", "of", "chronicity", ",", "hepatitis", "activity", "or", "disease", "stage"], "h": {"id": "C1413240", "name": "C1413240#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019189", "name": "C0019189#ent", "pos": [18, 19]}}
{"token": ["In", "the", "present", "study", ",", "C1413240#ent", "<e1>", "expression", "on", "blood", "lymphocytes", "patients", "with", "C0019189#ent", "<e2>", "infected", "with", "different", "HCV", "geno-/subtypes", "were", "analysed", "by", "fluorescence", "activated", "cell", "sorter", "analyses"], "h": {"id": "C1413240", "name": "C1413240#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019189", "name": "C0019189#ent", "pos": [13, 14]}}
{"token": ["A", "patient", "who", "presented", "with", "C0014869#ent", "<e1>", "hepatitis", "attributed", "to", "C0008783#ent", "<e2>", "."], "h": {"id": "C0014869", "name": "C0014869#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [10, 11]}}
{"token": ["Eighty", "patients", "with", "C0014869#ent", "<e1>", "randomised", "to", "receive", "either", "Pyrogastrone", "five", "tablets", "daily", "or", "C0008783#ent", "<e2>", "400", "mg", "twice", "daily", "for", "six", "weeks", ",", "extended", "to", "12", "if", "necessary", "."], "h": {"id": "C0014869", "name": "C0014869#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [14, 15]}}
{"token": ["The", "results", "of", "large", "double-blind", "trials", "in", "patients", "with", "C0014869#ent", "<e1>", "compare", "favorably", "with", "those", "reported", "using", "C0008783#ent", "<e2>", "and", "ranitidine", "."], "h": {"id": "C0014869", "name": "C0014869#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "C1366837#ent", "<e1>", "is", "sumoylated", "at", "C1705292#ent", "<e2>", "and", "K164", "."], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705292", "name": "C1705292#ent", "pos": [8, 9]}}
{"token": ["Although", "an", "infrequent", "side", "effect", "C0027947#ent", "<e1>", "has", "been", "described", "as", "a", "sequel", "of", "C0080151#ent", "<e2>", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [14, 15]}}
{"token": ["The", "literature", "on", "C0027947#ent", "<e1>", "during", "treatment", "with", "C0080151#ent", "<e2>", "and", "DMARDs", "is", "briefly", "reviewed", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [8, 9]}}
{"token": ["The", "biological", "natriuretic", "peptide", "type", "A", "receptor", "NPR-A", ")", "mediates", "ANF", "effects", ",", "since", "100", "nM", "C0070709#ent", "<e1>", ",", "a", "specific", "C0001645#ent", "<e2>", ",", "reversed", "ANF-dependent", "increase", "of", "DA", "uptake", "."], "h": {"id": "C0070709", "name": "C0070709#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [21, 22]}}
{"token": ["Ascorbic", "acid", "concentrations", "have", "been", "measured", "in", "leukocytes", "and", "plasma", "following", "oral", "administration", "2000", "mg", "vitamin", "C", "the", "same", "subjects", "while", "they", "had", "C0863093#ent", "<e1>", "after", "recovery", "from", "their", "C1949981#ent", "<e2>", "."], "h": {"id": "C0863093", "name": "C0863093#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1949981", "name": "C1949981#ent", "pos": [29, 30]}}
{"token": ["C0030304#ent", "<e1>", "was", "accompanied", "by", "C1963823#ent", "<e2>", ",", "diabetes", "mellitus", "acute", "renal", "failure", "due", "to", "acute", "tubular", "necrosis"], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1963823", "name": "C1963823#ent", "pos": [5, 6]}}
{"token": ["The", "C1366537#ent", "<e1>", "to", "be", "an", "isoform", "of", "the", "C0082645#ent", "<e2>", "is", "an", "apparent", "human", "homolog", "of", "the", "Saccharomyces", "cerevisiae", "cell-division-cycle", "protein", "CDC42Sc", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [9, 10]}}
{"token": ["Meningitis", "occurred", "in", "five", ",", "C0025309#ent", "<e1>", "with", "hemiplegia", "in", "one", ",", "paraplegia", "and", "C0262576#ent", "<e2>", "one", "and", "psychosis", "and/or", "nightmares", "in", "three", "."], "h": {"id": "C0025309", "name": "C0025309#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0262576", "name": "C0262576#ent", "pos": [14, 15]}}
{"token": ["C0026780#ent", "<e1>", "epidemics", "are", "followed", "by", "sporadic", "cases", "of", "C0011854#ent", "<e2>", "IDDM", ")", "."], "h": {"id": "C0026780", "name": "C0026780#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [9, 10]}}
{"token": ["Am-80", "is", "a", "newly", "snythesized", "C0035339#ent", "<e1>", "with", "the", "structure", "of", "one", "C0772162#ent", "<e2>", "retinobenzoic", "acids"], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0772162", "name": "C0772162#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "the", "removal", "of", "C1161318#ent", "<e1>", "aqueous", "solution", "by", "activated", "carbon", "impregnated", "with", "C1742019#ent", "<e2>", "studied", "in", "batch", "system"], "h": {"id": "C1161318", "name": "C1161318#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [16, 17]}}
{"token": ["Granules", "have", "been", "prepared", "by", "a", "standard", "method", "ternary", "mixtures", "lactose", ",", "C1161318#ent", "<e1>", "either", "sulphanilamide", ",", "heavy", "kaolin", "or", "C1742019#ent", "<e2>", "using", "an", "aqueous", "solution", "of", "polyvinylpyrrolidone", "as", "binder", "."], "h": {"id": "C1161318", "name": "C1161318#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [20, 21]}}
{"token": ["Vanadate", "also", "causes", "the", "partial", "accumulation", "of", "C1419841#ent", "<e1>", ",", "but", "not", "C1419839#ent", "<e2>", ",", "in", "\"", "patches", "\"", "at", "or", "near", "the", "cell", "surface"], "h": {"id": "C1419841", "name": "C1419841#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419839", "name": "C1419839#ent", "pos": [12, 13]}}
{"token": ["C0123053#ent", "<e1>", "Corvert", "--", "Pharmacia", "&", "Upjohn", ")", ",", "a", "new", "C0003195#ent", "<e2>", "intravenous", "use", "has", "been", "approved", "by", "the", "US", "Food", "and", "Drug", "Administration", "acute", "termination", "atrial", "fibrillation", "flutter", "of", "recent", "onset", "."], "h": {"id": "C0123053", "name": "C0123053#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [11, 12]}}
{"token": ["These", "antiarrhythmics", ",", "like", "sotalol", ",", "dofetilide", "and", "C0123053#ent", "<e1>", ",", "have", "been", "classified", "as", "C0003195#ent", "<e2>"], "h": {"id": "C0123053", "name": "C0123053#ent", "pos": [8, 9]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [15, 16]}}
{"token": ["JAK2", "was", "associated", "with", "C1335875#ent", "<e1>", ",", "and", "IL-12-induced", "C1335875#ent", "<e1>", "phosphorylation", "was", "elicited", "in", "the", "absence", "of", "C0253457#ent", "<e1>", "activation", "."], "h": {"id": "C1335875", "name": "C1335875#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0253457", "name": "C0253457#ent", "pos": [18, 19]}}
{"token": ["Endogenous", "norepinephrine", "(", "NE", ")", "activates", "both", "alpha(1)-adrenoceptors", "and", "C0033634#ent", "<e1>", "PKC", ")", ",", "which", ",", "in", "turn", ",", "activates", "C2932861#ent", "<e2>", "via", "phosphorylation", "thereby", "enhancing", "the", "production", "of", "interstitial", "adenosine"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2932861", "name": "C2932861#ent", "pos": [20, 21]}}
{"token": ["Here", ",", "we", "report", "an", "unusual", "case", "of", "Coombs'-negative", "autoimmune", "hemolytic", "anemia", "(", "C0772110#ent", "<e1>", ")", "with", "severe", "autoimmune", "leukopenia", "C0027947#ent", "<e2>", ",", "occurring", "simultaneously", ",", "in", "a", "patient", "with", "untreated", "hepatitis", "C", "infection"], "h": {"id": "C0772110", "name": "C0772110#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [20, 21]}}
{"token": ["Exposure", "of", "splenocytes", "to", "C0006863#ent", "<e1>", "elicited", "an", "early", "production", "of", "reactive", "oxygen", "species", "C0812281#ent", "<e2>", ")", "with", "the", "peak", "response", "1", "h", "post", "C0006863#ent", "<e1>", "treatment", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006863", "name": "C0006863#ent", "pos": [4, 5]}}
{"token": ["Thus", ",", "it", "appears", "that", "aciclovir", "has", "C0242912#ent", "<e1>", "which", "could", "possibly", "be", "useful", "in", "the", "treatment", "of", "C1332060#ent", "<e2>"], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332060", "name": "C1332060#ent", "pos": [18, 19]}}
{"token": ["A", "child", "with", "C1842577#ent", "<e1>", "episodic", "hyperpnoea", "abnormal", "eye-movements", "and", "C0004134#ent", "<e2>", ")", "was", "followed", "from", "birth", "to", "eight", "years", "of", "age", "."], "h": {"id": "C1842577", "name": "C1842577#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [10, 11]}}
{"token": ["Evaluation", "of", "hearing", "impairment", "a", "feature", "of", "the", "nonocular", "C0265253#ent", "<e1>", "type", "II", "linked", "to", "C1413571#ent", "<e2>", "."], "h": {"id": "C0265253", "name": "C0265253#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413571", "name": "C1413571#ent", "pos": [15, 16]}}
{"token": ["6-O-carboxymethyl-D-glucose", ",", "C0660801#ent", "<e1>", "and", "3-O-carboxymethyl-D-glucose", "were", "identified", "and", "determined", "in", "the", "reaction", "mixture", "C0037487#ent", "<e2>"], "h": {"id": "C0660801", "name": "C0660801#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037487", "name": "C0037487#ent", "pos": [14, 15]}}
{"token": ["It", "was", "observed", "previously", "that", "genetically", "selected", "Sardinian", "alcohol-preferring", "(", "sP", ")", "rats", "show", "a", "small", "number", "of", "C1706584#ent", "<e1>", "and", "HS", "following", "intracerebroventricular", "(", "ICV", ")", "injection", "of", "C0074331#ent", "<e2>", "."], "h": {"id": "C1706584", "name": "C1706584#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0074331", "name": "C0074331#ent", "pos": [29, 30]}}
{"token": ["The", "avian", "retrovirus", "pp32", "DNA", "endonuclease", "the", "beta", "polypeptide", "the", "C0035379#ent", "<e1>", "the", "same", "three", "phosphoserine", "(", "p-Ser", ")", "tryptic", "C0030956#ent", "<e2>", "."], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", "to", "these", "similarities", ",", "the", "FIV", "and", "C0035379#ent", "<e1>", "substantially", "different", "in", "primary", "sequence", "as", "determined", "by", "C0030956#ent", "<e2>", "mapping", "."], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}}
{"token": ["In", "four", ",", "the", "findings", "resembled", "those", "of", "a", "destructive", "C0949691#ent", "<e1>", ",", "and", "in", "two", ",", "a", "less", "destructive", "C3898123#ent", "<e2>"], "h": {"id": "C0949691", "name": "C0949691#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3898123", "name": "C3898123#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "the", "use", "of", "C0035064#ent", "<e1>", "that", "inhibit", "Kupffer", "cell", "function", "may", "be", "important", "for", "C1520007#ent", "<e2>", "treatment", "of", "liver", "disease"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1520007", "name": "C1520007#ent", "pos": [16, 17]}}
{"token": ["A", "gene", "(", "C1414395#ent", "<e1>", ")", "coding", "for", "an", "endoglucanase", "I", "C3899313#ent", "<e2>", ")", "was", "isolated", "from", "white", "rot", "fungus", "Irpex", "lacteus", "MC-2", "."], "h": {"id": "C1414395", "name": "C1414395#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3899313", "name": "C3899313#ent", "pos": [11, 12]}}
{"token": ["The", "shared", "region", "a", "homeo", "domain", "is", "within", "the", "region", "of", "C1414395#ent", "<e1>", "shared", "with", "the", "Drosophila", "invected", "gene", "and", "the", "mouse", "C3899313#ent", "<e2>", "and", "En-2", "genes", "."], "h": {"id": "C1414395", "name": "C1414395#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3899313", "name": "C3899313#ent", "pos": [22, 23]}}
{"token": ["C0030312#ent", "<e1>", ",", "hepatosplenomegaly", "and", "skeletal", "complications", "are", "hallmarks", "of", "C1961835#ent", "<e2>"], "h": {"id": "C0030312", "name": "C0030312#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [10, 11]}}
{"token": ["C1259877#ent", "<e1>", "inhibitors", "blocked", "PMA", "induction", "of", "C1823521#ent", "<e2>", "promoter", "activity", "an", "inhibition", "profile", "suggestive", "of", "involvement", "of", "PKCepsilon", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [7, 8]}}
{"token": ["As", "an", "animal", "model", "experimentally", "induced", "C0029408#ent", "<e1>", "in", "primates", "appears", "to", "resemble", "an", "C0022408#ent", "<e2>", "man", "rather", "than", "chronic", "rheumatoid", "arthritis"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [14, 15]}}
{"token": ["By", "transplanting", "cells", "C0016053#ent", "<e1>", "mutants", "and", "either", "C2987364#ent", "<e2>", "or", "nacre", "mutant", "zebrafish", ",", "we", "show", "that", "C0016053#ent", "<e1>", "acts", "autonomously", "to", "the", "xanthophore", "lineage", "in", "promoting", "the", "striped", "arrangement", "adult", "melanophores", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016053", "name": "C0016053#ent", "pos": [3, 4]}}
{"token": ["The", "inhibition", "of", "lordosis", "is", "apparently", "not", "due", "to", "some", "unknown", "side", "effect", "C0032912#ent", "<e1>", "because", "pretreatment", "with", "a", "high", "dose", "C0009014#ent", "<e2>", "attenuated", "the", "inhibition", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [21, 22]}}
{"token": ["HR", "and", "blood", "pressure", "at", "each", "xamoterol", "level", "were", "compared", "before", "and", "after", "inhibition", "of", "cardiovascular", "reflexes", "C0032912#ent", "<e1>", ",", "atropine", ",", "and", "C0009014#ent", "<e2>", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [23, 24]}}
{"token": ["The", "addition", "of", "C0032912#ent", "<e1>", "increased", "the", "antihypertensive", "effects", "atenolol", "but", "not", "of", "C0009014#ent", "<e2>", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [13, 14]}}
{"token": ["In", "the", "older", "rats", "EEG", "variations", "were", "smaller", "for", "C0032912#ent", "<e1>", "and", "yohimbine", ",", "but", "larger", "for", "C0009014#ent", "<e2>", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [17, 18]}}
{"token": ["The", "major", "pattern", "recognition", "proteins", "receptors", ",", "which", "bind", "C1415192#ent", "<e1>", ",", "either", "have", "a", "lectin", ",", "C1420354#ent", "<e2>", "recognition", ",", "collagen", "or", "leucine-rich", "repeat", "LRR", ")", "domain", "."], "h": {"id": "C1415192", "name": "C1415192#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420354", "name": "C1420354#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "uPAR", ",", "MMP-1", ",", "MMP-2", ",", "C1704883#ent", "<e1>", "and", "MT3-MMP", "showed", "a", "a", "stronger", "expression", "and", "C3887675#ent", "<e2>", "a", "weaker", "expression", "in", "the", "seminoma", "xenografts", "did", "TCam-2", "cells", "."], "h": {"id": "C1704883", "name": "C1704883#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3887675", "name": "C3887675#ent", "pos": [19, 20]}}
{"token": ["The", "predominant", "C3540017#ent", "<e1>", "in", "the", "preparation", "represent", "trypsin-like", "activity", "associated", "with", "C2717971#ent", "<e2>"], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [12, 13]}}
{"token": ["Successive", "glycolytic", "C3540772#ent", "<e1>", "have", "been", "shown", "to", "associate", "in", "the", "cytosol", "as", "C0026741#ent", "<e2>", "bind", "to", "the", "thin", "filaments"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [13, 14]}}
{"token": ["The", "requirement", "of", "citrate", "lyase", "the", "CoA-like", "prosthetic", "group", "may", "arise", "from", "the", "substrate", "requirement", "of", "both", "subunit", "C3540772#ent", "<e1>", "of", "the", "C0026741#ent", "<e2>"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [22, 23]}}
{"token": ["To", "account", "for", "the", "latter", "result", ",", "we", "postulate", "that", "the", "C3540772#ent", "<e1>", "involved", "in", "sulfate", "assimilation", "may", "occur", "as", "a", "C0026741#ent", "<e2>", "S.", "cerevisiae"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [21, 22]}}
{"token": ["Several", "bacteriophages", "use", "the", "Escherichia", "coli", "C1415790#ent", "<e1>", "and", "GroEL", "chaperonins", "for", "folding", "and", "assembly", "of", "their", "C1136352#ent", "<e2>"], "h": {"id": "C1415790", "name": "C1415790#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136352", "name": "C1136352#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "show", "a", "strong", "conservation", "between", "the", "-14", "C0079429#ent", "<e1>", "and", "the", "mouse", "C1418951#ent", "<e2>", "gene", "with", "the", "exception", "of", "the", "first", "exon", "of", "the", "mProx1", "gene"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418951", "name": "C1418951#ent", "pos": [14, 15]}}
{"token": ["A", "now", "36-year-old", "woman", "developed", "a", "C0340757#ent", "<e1>", "9", "years", "after", "liver", "transplantation", "extensive", "C0013504#ent", "<e2>"], "h": {"id": "C0340757", "name": "C0340757#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013504", "name": "C0013504#ent", "pos": [14, 15]}}
{"token": ["Also", ",", "the", "effect", "of", "C3273549#ent", "<e1>", "on", "cyclooxygenase", "1", "2", "expression", "in", "C0001214#ent", "<e2>", "evaluated", "."], "h": {"id": "C3273549", "name": "C3273549#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001214", "name": "C0001214#ent", "pos": [13, 14]}}
{"token": ["Hyperinsulinemia", "associated", "with", "insulin", "resistance", "been", "causally", "linked", "to", "all", "features", "of", "the", "C1848862#ent", "<e1>", ",", "such", "as", "hyperandrogenism", ",", "reproductive", "disorders", "C0702166#ent", "<e2>", ",", "hirsutism", ",", "and", "metabolic", "disturbances"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0702166", "name": "C0702166#ent", "pos": [22, 23]}}
{"token": ["SAPHO", ",", "a", "rare", "C1848862#ent", "<e1>", ",", "is", "a", "recently", "suggested", "acronym", "for", "synovitis", ",", "C0702166#ent", "<e2>", ",", "pustulosis", ",", "hyperostosis", "and", "osteitis", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0702166", "name": "C0702166#ent", "pos": [15, 16]}}
{"token": ["C0078538#ent", "<e1>", "is", "the", "disulfide", "moiety", "the", "clinically", "studied", "C0007209#ent", "<e2>", "S-2-(3-aminopropylamino)ethylphosphorothioic", "acid", "WR-2721", ")", "."], "h": {"id": "C0078538", "name": "C0078538#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [9, 10]}}
{"token": ["Of", "several", "C0991617#ent", "<e1>", "recently", "shown", "to", "reduce", "C1366489#ent", "<e2>", "in", "phase", "II", "studies", "13-cis-retinoic", "acid", "interferon-alpha", "can", "reduce", "the", "expression", "of", "bcl-2", "and", "overcome", "bcl-2-mediated", "resistance", "to", "paclitaxel", "in", "resistant", "cell", "lines"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366489", "name": "C1366489#ent", "pos": [8, 9]}}
{"token": ["The", "aim", "of", "this", "study", "was", "therefore", "to", "estimate", "the", "impact", "of", "C0679247#ent", "<e1>", "prior", "pregnancy", "outcome", "the", "use", "of", "analgesics/antipyretics", ",", "C0003205#ent", "<e2>", "and", "antihistamines", "in", "early", "pregnancy", "for", "socio-demographic", "factors"], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003205", "name": "C0003205#ent", "pos": [22, 23]}}
{"token": ["These", "C0026794#ent", "<e1>", "are", "inhibited", "by", "concurrent", "medications", ",", "including", "the", "calcium", "channel", "antagonist", "C0012373#ent", "<e2>", ",", "which", "may", "have", "an", "effect", "on", "recovery", "from", "anesthesia", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012373", "name": "C0012373#ent", "pos": [14, 15]}}
{"token": ["C0014858#ent", "<e1>", "be", "an", "important", "cause", "of", "C0002962#ent", "<e2>"], "h": {"id": "C0014858", "name": "C0014858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [7, 8]}}
{"token": ["With", "C0009325#ent", "<e1>", "this", "difference", "persisted", "after", "ingestion", "of", "125", "mg", "C0050537#ent", "<e2>", "ASA", ")", "which", "might", "in", "part", "explain", "the", "greater", "therapeutic", "benefit", "of", "ASA", "for", "men", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0050537", "name": "C0050537#ent", "pos": [11, 12]}}
{"token": ["After", "C0050537#ent", "<e1>", "and", "with", "the", "same", "amount", "of", "C0009325#ent", "<e2>", "as", "before", "C0050537#ent", "<e1>", "aggregation", "decreased", "by", "82", "+", "/-", "4", "%", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0050537", "name": "C0050537#ent", "pos": [1, 2]}}
{"token": ["However", ",", "although", "C1413603#ent", "<e1>", "can", "be", "obtained", "relatively", "easily", "in", "vitro", "quinidine", "or", "C0026289#ent", "<e2>", ",", "torsades", "de", "pointes", "very", "difficult", "to", "reproduce", "in", "animal", "models"], "h": {"id": "C1413603", "name": "C1413603#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026289", "name": "C0026289#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "of", "chronic", "renal", "failure", "C0022661#ent", "<e1>", ")", "on", "the", "pharmacokinetics", "of", "C0023660#ent", "<e2>", ",", "a", "drug", "cleared", "almost", "exclusively", "by", "hepatic", "metabolism", "has", "thus", "far", "only", "been", "evaluated", "in", "patients", "undergoing", "regular", "hemodialysis"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [13, 14]}}
{"token": ["The", "mean", "C0720099#ent", "<e1>", "of", "migraine", "attacks", "treated", "with", "C0020740#ent", "<e2>", "was", "significantly", "shorter", "than", "the", "C0720099#ent", "<e1>", "of", "migraine", "attacks", "treated", "with", "placebo", "."], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [2, 3]}}
{"token": ["These", "findings", "indicate", "that", "very", "low", "levels", "of", "C0724532#ent", "<e1>", "are", "associated", "with", "disseminated", "C0012739#ent", "<e2>", "neonates", "with", "IRDS", "and", "suggest", "that", "a", "deficiency", "of", "C0724532#ent", "<e1>", "is", "predictive", "of", "a", "poor", "outcome"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0724532", "name": "C0724532#ent", "pos": [8, 9]}}
{"token": ["Incubation", "of", "pig", "desoctapeptide-(B23", "-", "30)-insulin", "with", "C0960371#ent", "<e1>", "in", "solvent", "systems", "of", "dimethyl", "sulphoxide", "C0020306#ent", "<e2>", "and", "Tris", "buffer", "in", "the", "formation", "of", "an", "extra", "peptide", "bond", "between", "Arg-B22", "and", "Gly-A1", "in", "the", "DOPI", "molecule"], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020306", "name": "C0020306#ent", "pos": [15, 16]}}
{"token": ["Functional", "achievement", "the", "principal", "care", "than", "pain", "self-report", "the", "most", "effective", "manoeuvre", "to", "avoid", "the", "C0150055#ent", "<e1>", "the", "failed", "C0024031#ent", "<e2>"], "h": {"id": "C0150055", "name": "C0150055#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [19, 20]}}
{"token": ["Large-scale", "RNA", "differential", "display", "technology", "applied", "to", "these", "cell", "lines", "several", "differentially", "expressed", "C1417679#ent", "<e1>", ",", "including", "an", "alpha", "carbonic", "anhydrase", "gene", "termed", "C2346918#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2346918", "name": "C2346918#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "show", "that", "breast-ovarian", "cancer", "susceptibility", "1", "C0376571#ent", "<e1>", ")", "interacts", "directly", "with", "C2243119#ent", "<e2>", "ATRIP", ")", ",", "an", "obligate", "partner", "of", "ATR", "."], "h": {"id": "C0376571", "name": "C0376571#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2243119", "name": "C2243119#ent", "pos": [15, 16]}}
{"token": ["The", "interaction", "involves", "the", "BRCT", "domains", "of", "C0376571#ent", "<e1>", "and", "Ser(239", ")", "of", "C2243119#ent", "<e2>", ",", "a", "residue", "that", "is", "phosphorylated", "in", "both", "irradiated", "and", "nonirradiated", "cells", "."], "h": {"id": "C0376571", "name": "C0376571#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2243119", "name": "C2243119#ent", "pos": [13, 14]}}
{"token": ["These", "results", "support", "the", "conclusions", "that", "C0002934#ent", "<e1>", "be", "administered", "to", "C0024591#ent", "<e2>", "patients", "without", "significant", "risk", "and", "that", "currently", "the", "diagnosis", "of", "MH", "susceptibility", "can", "adversely", "affect", "the", "quality", "of", "dental", "care"], "h": {"id": "C0002934", "name": "C0002934#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024591", "name": "C0024591#ent", "pos": [11, 12]}}
{"token": ["The", "long", "isoform", "of", "leptin", "receptor", "OB-Rb", ")", "was", "present", "in", "normal", "pituitary", "and", "in", "various", "C0032002#ent", "<e1>", "including", "FS", ",", "C1704975#ent", "<e2>", ",", "and", "alphaT3", "-", "1", "cells", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704975", "name": "C1704975#ent", "pos": [21, 22]}}
{"token": ["We", "have", "compared", "the", "influence", "of", "insulin-like", "growth", "factor", "1", "IGF-1", ")", "on", "C0032002#ent", "<e1>", "expression", "in", "the", "rat", "cell", "lines", "and", "C1704975#ent", "<e2>", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704975", "name": "C1704975#ent", "pos": [22, 23]}}
{"token": ["Recently", ",", "an", "interaction", "between", "caveolin-3", "and", "dysferlin", "in", "normal", "and", "C0026850#ent", "<e1>", "primary", "caveolin-3", "deficiency", ";", "C1832567#ent", "<e2>", ")", "was", "shown", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1832567", "name": "C1832567#ent", "pos": [17, 18]}}
{"token": ["Pretreated", "U0126", "abolished", "the", "C1540159#ent", "<e1>", "elicited", "by", "glutamatergic", "agonists", "glutamate", ",", "C0022614#ent", "<e2>", "and", "AMPA", "."], "h": {"id": "C1540159", "name": "C1540159#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [12, 13]}}
{"token": ["Both", "CYP1A2", "and", "CYP3A4", "catalyzed", "N-dealkylation", "of", "C0700465#ent", "<e1>", ",", "with", "specific", "activities", "of", "0.32", "pmol/min/pmol", "of", "C0534137#ent", "<e2>", "and", "0.16", "pmol/min/pmol", "of", "C0534137#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0700465", "name": "C0700465#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "suggest", "that", "C0675175#ent", "<e1>", "are", "one", "of", "the", "causes", "of", "persistent", "bronchoconstriction", "in", "C0155883#ent", "<e2>"], "h": {"id": "C0675175", "name": "C0675175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155883", "name": "C0155883#ent", "pos": [15, 16]}}
{"token": ["Studies", "that", "used", "cholestyramine", "and", "the", "combination", "of", "C0009279#ent", "<e1>", "and", "niacin", "resulted", "in", "decreased", "progression", "of", "C1956346#ent", "<e2>"], "h": {"id": "C0009279", "name": "C0009279#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [17, 18]}}
{"token": ["This", "amplicon", "was", "digested", "separately", "with", "three", "(", "C0162809#ent", "<e1>", ",", "MboII", ",", "and", "Sau3A", ")", "C0012906#ent", "<e2>"], "h": {"id": "C0162809", "name": "C0162809#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [16, 17]}}
{"token": ["The", "DNA", "was", "subsequently", "cleaved", "with", "either", "Alu", "I", ",", "Hae", "III", "C0162809#ent", "<e1>", "Hinf", "I", "or", "C0012906#ent", "<e2>", "the", "restriction", "fragments", "isolated", "by", "gel", "electrophoresis"], "h": {"id": "C0162809", "name": "C0162809#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [17, 18]}}
{"token": ["Patients", "with", "fistulas", "due", "to", "C0012819#ent", "<e1>", ",", "to", "a", "lesser", "extent", ",", "C0156147#ent", "<e2>", "look", "forward", "to", "complete", "correction", "with", "low", "mortality", "and", "morbidity", "."], "h": {"id": "C0012819", "name": "C0012819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [13, 14]}}
{"token": ["These", "distinct", "roles", "for", "the", "SH3", "binding", "sites", "C4277570#ent", "<e1>", "be", "important", "for", "protein", "targeting", "and", "C0027203#ent", "<e2>", "activation", "."], "h": {"id": "C4277570", "name": "C4277570#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}}
{"token": ["Whether", "patients", "with", "C3665349#ent", "<e1>", "have", "an", "increased", "prevalence", "of", "C0037090#ent", "<e2>", "unknown", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037090", "name": "C0037090#ent", "pos": [10, 11]}}
{"token": ["resulted", "in", "a", "significant", "increase", "in", "serum", "C1418938#ent", "<e1>", "within", "4", "h", ";", "however", ",", "cocaine", "or", "mazindol", "administration", "abolished", "the", "C2987147#ent", "<e2>", "increase", "of", "C1418938#ent", "<e1>", "."], "h": {"id": "C2987147", "name": "C2987147#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [7, 8]}}
{"token": ["Concurrent", "treatment", "with", "the", "synthetic", "glucocorticoid", "dexamethasone", "reduced", "the", "C2987147#ent", "<e1>", "transcription", "rate", "of", "the", "C1418938#ent", "<e2>", "and", "rPRL-Tn5", "gene", "to", "near", "basal", "levels", "."], "h": {"id": "C2987147", "name": "C2987147#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [15, 16]}}
{"token": ["C0008273#ent", "<e1>", ",", "loop", "diuretics", "aldosterone", "antagonists", "needed", "for", "acute", "and", "chronic", "treatment", "C0018801#ent", "<e2>", "alone", "or", "in", "combination", "(", "diuretic", "resistant", "heart", "failure", ")", "."], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [13, 14]}}
{"token": ["The", "different", "sites", "of", "action", "explain", "the", "clinically", "proven", "efficacious", "combination", "of", "C0008273#ent", "<e1>", "and", "loop-diuretics", "in", "severe", "C0018801#ent", "<e2>"], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}}
{"token": ["Although", "rubber", "seed", "meal", "protein", "is", "of", "poorer", "quality", "than", "C0677666#ent", "<e1>", "growing", "pigs", ",", "at", "least", "10", "%", "of", "C0012177#ent", "<e2>", "be", "provided", "by", "rubber", "seed", "meal", "adversely", "affecting", "growth", "and", "N", "utilization"], "h": {"id": "C0677666", "name": "C0677666#ent", "pos": [10, 11]}, "relation": "has_structural_class", "t": {"id": "C0012177", "name": "C0012177#ent", "pos": [20, 21]}}
{"token": ["This", "study", "investigates", "whether", "the", "effects", "of", "increased", "dietary", "levels", "C0677666#ent", "<e1>", "zinc-deficient", "rats", "are", "due", "to", "the", "C0012177#ent", "<e2>", "."], "h": {"id": "C0677666", "name": "C0677666#ent", "pos": [10, 11]}, "relation": "has_structural_class", "t": {"id": "C0012177", "name": "C0012177#ent", "pos": [18, 19]}}
{"token": ["One", "patient", "with", "C0036130#ent", "<e1>", "diagnostic", "laparoscopy", ";", "two", "patients", "underwent", "laparotomy", "(", "C0564755#ent", "<e2>", "perforated", "diverticulitis", "."], "h": {"id": "C0036130", "name": "C0036130#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0564755", "name": "C0564755#ent", "pos": [13, 14]}}
{"token": ["The", "patients", "who", "improved", "with", "a", "DA", "antagonist", "or", "an", "ACh", "C0243192#ent", "<e1>", "improved", "while", "taking", "C0011064#ent", "<e2>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011064", "name": "C0011064#ent", "pos": [16, 17]}}
{"token": ["According", "to", "a", "current", "theory", "about", "the", "pathogenesis", "of", "C0376175#ent", "<e1>", "the", "motorfibers", "of", "the", "facial", "nerve", "affected", "by", "a", "C0442874#ent", "<e2>", "transmitted", "to", "the", "facial", "nerve", "the", "axons", "of", "the", "chorda", "tympani", "nerve"], "h": {"id": "C0376175", "name": "C0376175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [20, 21]}}
{"token": ["For", "example", ",", "fatty", "acid", "synthase", "gene", "transcription", "is", "inhibited", "by", "specific", "polyunsaturated", "fatty", "acids", "S14", "and", "C0034348#ent", "<e1>", "a", "specific", "C1826259#ent", "<e2>", "and", "editing", "of", "apo", "B-100", "apo", "B-48", "enhanced", "by", "dietary", "carbohydrate"], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1826259", "name": "C1826259#ent", "pos": [21, 22]}}
{"token": ["Tyrosine", "phosphorylation", "PZR", "was", "accompanied", "by", "recruitment", "of", "SHP-2", "and", "was", "inhibited", "by", "C1418858#ent", "<e1>", ",", "a", "selective", "inhibitor", "of", "the", "C0282625#ent", "<e2>"], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "the", "tyrosine", "phosphorylation", "activation", "of", "MAPK", "was", "dependent", "on", "Src", "kinase", "since", "C1418858#ent", "<e1>", "(", "10", "and", "20microM", ")", ",", "a", "specific", "C0282625#ent", "<e2>", "blocked", "PTH-induced", "MAPK", "activation", "."], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [24, 25]}}
{"token": ["We", "report", "a", "case", "of", "C1705969#ent", "<e1>", "presenting", "with", "C0023885#ent", "<e2>", "review", "the", "literature", "and", "discuss", "the", "management", "options", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023885", "name": "C0023885#ent", "pos": [9, 10]}}
{"token": ["This", "phenomenon", "is", "due", "to", "Phosphate", "regulating", "with", "Homolgy", "to", "C0207564#ent", "<e1>", "on", "the", "X", "chromosome", "PHEX", ")", "C0678941#ent", "<e2>"], "h": {"id": "C0207564", "name": "C0207564#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0678941", "name": "C0678941#ent", "pos": [18, 19]}}
{"token": ["Interestingly", ",", "C2714964#ent", "<e1>", "also", "increased", "the", "cAMP", "concentration", "and", "C0033640#ent", "<e2>", "activity", "."], "h": {"id": "C2714964", "name": "C2714964#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [10, 11]}}
{"token": ["This", "syndrome", "is", "usually", "associated", "with", "C1280433#ent", "<e1>", "central", "adiposity", ",", "in", "some", "cases", ",", "C2931642#ent", "<e2>", ",", "as", "well", "as", "systemic", "insulin", "resistance", "hyperlipidemia", "."], "h": {"id": "C1280433", "name": "C1280433#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2931642", "name": "C2931642#ent", "pos": [15, 16]}}
{"token": ["The", "assembly", "and", "release", "of", "C0009450#ent", "<e1>", "particles", "was", "studied", "under", "conditions", "of", "C1419221#ent", "<e2>", "overexpression", "in", "a", "transient", "transfection", "assay", "suppression", "by", "RNA", "interference"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419221", "name": "C1419221#ent", "pos": [13, 14]}}
{"token": ["A", "turbidimetric", "esterase", "assay", "was", "developed", "using", "a", "Tween", "20", "solution", "in", "the", "presence", "of", "C1414518#ent", "<e1>", "and", "Lysobacter", "enzymogenes", "esterase", "(", "C1258847#ent", "<e2>", "as", "the", "enzyme", "source", "."], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [22, 23]}}
{"token": ["Optimum", "pH", "was", "7.1", "-", "7.6", "and", "optimal", "concentration", "of", "retinol", "was", "15", "muM.", "With", "C1414518#ent", "<e1>", ",", "the", "formation", "of", "C1258847#ent", "<e2>", "1.00", "+", "/-", "0.26", "nmol", "."], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [21, 22]}}
{"token": ["[14C]Palmitate", "from", "C1414518#ent", "<e1>", "is", "incorporated", "into", "preexisting", "C1258847#ent", "<e2>", "the", "absence", "of", "net", "ester", "synthesis", "too", "."], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [8, 9]}}
{"token": ["C0073096#ent", "<e1>", "reduced", "pyrogallol-mediated", "increase", "in", "C0057041#ent", "<e2>", "aspartate", "aminotransaminase", "bilirubin", ",", "lipid", "peroxidation", "mRNA", "expression", "and", "catalytic", "activity", "CYP2E1", "and", "CYP1A2", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0057041", "name": "C0057041#ent", "pos": [6, 7]}}
{"token": ["Forty-six", "of", "48", "patients", "(", "95.8", "%", ")", "who", "had", "evidence", "of", "C0149649#ent", "<e1>", "had", "severe", "C0003850#ent", "<e2>", "of", "the", "ascending", "aorta"], "h": {"id": "C0149649", "name": "C0149649#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [16, 17]}}
{"token": ["The", "death", "is", "accompanied", "by", "cleavage", "of", "the", "C0010656#ent", "<e1>", "poly", "ADP", "ribose", "polymerase", "PARP", ")", "and", "c-Abl-dependent", "activation", "of", "the", "C0380241#ent", "<e2>", "c-Jun", "N-terminal", "kinase", "p38", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0380241", "name": "C0380241#ent", "pos": [21, 22]}}
{"token": ["We", "found", "when", "we", "switched", "off", "v-Src", "the", "cells", "died", "by", "apoptosis", "characterised", "by", "activation", "of", "C0010656#ent", "<e1>", "and", "the", "C0380241#ent", "<e2>", "JNK", "(", "Jun", "N-terminal", "kinase", "and", "p38", "MAP", "mitogen", "activated", "protein", "kinase", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0380241", "name": "C0380241#ent", "pos": [20, 21]}}
{"token": ["We", "have", "purified", "and", "characterized", "a", "C1418288#ent", "<e1>", "PYC", ")", "from", "Mycobacterium", "smegmatis", "cloned", "and", "sequenced", "its", "C0079429#ent", "<e2>", "."], "h": {"id": "C1418288", "name": "C1418288#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}}
{"token": ["A", "total", "of", "144", "individuals", "was", "examined", ":", "62", "normal", "persons", "34", "patients", "with", "cardiac", "insufficiency", "31", "patients", "with", "hyperkinetic", "syndrome", "effort", "syndrome", "C3831153#ent", "<e1>", ")", "and", "17", "patients", "with", "isolated", "C1331537#ent", "<e2>", "impairment", "of", "cardiac", "function"], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1331537", "name": "C1331537#ent", "pos": [31, 32]}}
{"token": ["Autolysis", "of", "C1413109#ent", "<e1>", "was", "associated", "with", "degradation", "of", "C1413980#ent", "<e2>", "and", "drip", "or", "purge", "loss", "postmortem"], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413980", "name": "C1413980#ent", "pos": [9, 10]}}
{"token": ["The", "studies", "described", "herein", "examined", "an", "unusual", "effect", "of", "C0338271#ent", "<e1>", "in", "increasing", "C0669365#ent", "<e2>", "testosterone", "levels", "of", "cultured", "Leydig", "cells", "young", "adult", "rats", "."], "h": {"id": "C0338271", "name": "C0338271#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [13, 14]}}
{"token": ["Sequence", "analysis", "their", "C0042720#ent", "<e1>", "that", "they", "are", "related", "to", "the", "Icelandic", "and", "Japanese", "C1875400#ent", "<e2>", "."], "h": {"id": "C0042720", "name": "C0042720#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [14, 15]}}
{"token": ["Host", "risk", "factors", ":", "advanced", "age", "hypertension", ",", "gout", "and", "C0041983#ent", "<e1>", ",", "diabetes", "mellitus", "chronic", "renal", "failure", "use", "of", "C0596110#ent", "<e2>", "."], "h": {"id": "C0041983", "name": "C0041983#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [20, 21]}}
{"token": ["To", "investigate", "the", "expression", "of", "C0079471#ent", "<e1>", "in", "renal", "interstitial", "fibrosis", "rats", "and", "the", "effect", "of", "C0014027#ent", "<e2>", "on", "it", "."], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014027", "name": "C0014027#ent", "pos": [16, 17]}}
{"token": ["We", "describe", "four", "cases", "of", "childhood", "B-cell", "progenitor", "acute", "lymphoblastic", "leukaemia", "BCP-ALL", ")", "and", "one", "of", "T-cell", "(", "T-ALL", ")", "with", "unexpected", "numbers", "of", "interphase", "signals", "for", "C0796520#ent", "<e1>", "with", "an", "C0919449#ent", "<e2>"], "h": {"id": "C0796520", "name": "C0796520#ent", "pos": [27, 28]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0919449", "name": "C0919449#ent", "pos": [31, 32]}}
{"token": ["Association", "of", "CD34-negative", "phenotype", ",", "peak", "incidence", "the", "3-", "to", "7-year", "age", "group", "and", "a", "comparatively", "low", "frequency", "of", "C0796520#ent", "<e1>", "homologue", "loss", "in", "C0919449#ent", "<e2>", "cases", "were", "distinct", "findings", "in", "this", "series", "."], "h": {"id": "C0796520", "name": "C0796520#ent", "pos": [19, 20]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0919449", "name": "C0919449#ent", "pos": [24, 25]}}
{"token": ["They", "are", "well", "tolerated", ",", "are", "not", "associated", "with", "depression", ",", "C0242350#ent", "<e1>", ",", "bronchospasm", "or", "C0025517#ent", "<e2>", "as", "hypokalemia", ",", "hyperuricemia", "or", "hyperglycemia", ",", "and", "do", "not", "have", "adverse", "effects", "the", "quality", "of", "life"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [16, 17]}}
{"token": ["In", "both", "instances", "C0494475#ent", "<e1>", "the", "presenting", "features", "with", "radiological", "and", "biochemical", "evidence", "of", "C1527410#ent", "<e2>", "."], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1527410", "name": "C1527410#ent", "pos": [14, 15]}}
{"token": ["The", "ethanol", "extract", "D.", "indica", "not", "only", "reduced", "production", "of", "pro-inflammatory", "cytokines", "and", "C0127400#ent", "<e1>", "and", "blocked", "C2986464#ent", "<e2>", "but", "also", "slightly", "promoted", "release", "of", "the", "anti-inflammatory", "mediator", "HO-1", "and", "suppressed", "IL-10", "secretion", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [17, 18]}}
{"token": ["Knowing", "that", "serine", "proteases", "as", "trypsin", "are", "highly", "C0127400#ent", "<e1>", "diverse", "biological", "activities", "the", "stimulation", "of", "nuclear", "factor-kappa", "B", "C2986464#ent", "<e2>", ")", "and", "interleukin", "(IL)-8", "the", "role", "of", "protease-activated", "receptors", "PAR", ")", "in", "inflammatory", "signal", "mediation", "investigated", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [19, 20]}}
{"token": ["A", "GLC", "method", "is", "described", "for", "the", "determination", "of", "iminodibenzyl", "and", "C0011685#ent", "<e1>", "impurities", "in", "C0282107#ent", "<e2>", "its", "formulated", "products", "."], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0282107", "name": "C0282107#ent", "pos": [15, 16]}}
{"token": ["With", "the", "object", "of", "studying", "the", "kinetics", "of", "imipramine", "and", "C0011685#ent", "<e1>", "five", "healthy", "volunteers", "single", "intramuscular", ",", "oral", "and", "intravenous", "doses", "multiple", "oral", "doses", "C0282107#ent", "<e2>", "different", "occasions", "."], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282107", "name": "C0282107#ent", "pos": [25, 26]}}
{"token": ["The", "term", "hypertrophic", "cardiomyopathy", "used", "to", "describe", "an", "autosomal", "dominant", "C0018799#ent", "<e1>", "characterized", "by", "myocyte", "hypertrophy", "disarray", ",", "interstitial", "fibrosis", "C3275121#ent", "<e2>", "with", "or", "without", "macroscopic", "hypertrophy", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [20, 21]}}
{"token": ["C0053355#ent", "<e1>", "also", "inhibited", "C0026254#ent", "<e2>", "L1210-caused", "decreases", "of", "delayed", "cutaneous", "hypersensitivity", "picryl", "chloride"], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [4, 5]}}
{"token": ["The", "effectiveness", "of", "C0053355#ent", "<e1>", "combined", "with", "C0026254#ent", "<e2>", ",", "FT-207", "for", "treating", "gastric", "cancer", "investigated", "in", "a", "prospective", "randomized", "controlled", "study"], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [7, 8]}}
{"token": ["The", "effectiveness", "of", "C0053355#ent", "<e1>", "combined", "with", "C0026254#ent", "<e2>", "tegafur", "as", "an", "adjuvant", "to", "surgery", "for", "gastric", "cancer", "investigated", "in", "a", "prospective", "randomized", "controlled", "study"], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [7, 8]}}
{"token": ["Caldesmon", "also", "inhibited", "the", "C1417500#ent", "<e1>", "+", "-ATPase", "activity", "of", "C0949660#ent", "<e2>", "the", "absence", "of", "actin", ";", "this", "inhibition", "also", "could", "be", "overcome", "by", "Ca2+/calmodulin", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0949660", "name": "C0949660#ent", "pos": [10, 11]}}
{"token": ["Both", "of", "the", "isolated", "microfilaments", "had", "the", "ability", "to", "activate", "the", "C1417500#ent", "<e1>", "+", "-ATPase", "activity", "of", "C0949660#ent", "<e2>", "although", "different", "extents", "of", "activation", "were", "observed", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0949660", "name": "C0949660#ent", "pos": [17, 18]}}
{"token": ["A", "case", "of", "C0023348#ent", "<e1>", "erythema", "nodosum", "leprosum", "ENL", ")", "undergoing", "treatment", "with", "C1639494#ent", "<e2>", ",", "rifampin", ",", "and", "thalidomide", "developed", "focal", "tuberculoid", "granulomas", "the", "ENL", "lesions", "."], "h": {"id": "C0023348", "name": "C0023348#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [13, 14]}}
{"token": ["Therefore", "initial", "intensive", "combined", "treatment", "with", "two", "or", "more", "bactericidal", "drugs", "including", "rifampicin", ")", "warrants", "further", "investigation", "in", "both", "untreated", "leprosy", "and", "C0023348#ent", "<e1>", "resistant", "to", "C1639494#ent", "<e2>", "."], "h": {"id": "C0023348", "name": "C0023348#ent", "pos": [22, 23]}, "relation": "may_be_treated_by", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [26, 27]}}
{"token": ["The", "histoid", "type", "of", "leprosy", "been", "described", "as", "occurring", "in", "C0023348#ent", "<e1>", "patients", "who", "relapse", "after", "many", "years", "of", "apparently", "successful", "C1639494#ent", "<e2>", "monotherapy", "."], "h": {"id": "C0023348", "name": "C0023348#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [21, 22]}}
{"token": ["We", "have", "investigated", "the", "expression", "of", "Jun", "family", "proteins", "composition", "of", "C0812312#ent", "<e1>", "in", "chicken", "embryo", "fibroblasts", "before", "and", "after", "transformation", "by", "the", "C0085300#ent", "<e2>", "ASV17", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085300", "name": "C0085300#ent", "pos": [23, 24]}}
{"token": ["Of", "interest", "was", "the", "finding", "that", "12-O-tetradecanoylphorbol-13-acetate", "induction", "other", "cellular", "genes", "to", "be", "regulated", "by", "C0812312#ent", "<e1>", "was", "not", "inhibited", "in", "the", "benign", "tumor", "cells", "expressing", "C0085300#ent", "<e2>", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085300", "name": "C0085300#ent", "pos": [26, 27]}}
{"token": ["C0035309#ent", "<e1>", "on", "the", "first", "examination", "progressed", "severely", "so", "that", "C0154841#ent", "<e2>", "retinal", "neovascularization", "3", "months", "later", "."], "h": {"id": "C0035309", "name": "C0035309#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0154841", "name": "C0154841#ent", "pos": [10, 11]}}
{"token": ["We", "suggest", "that", "the", "loss", "of", "critical", "populations", "of", "hypothalamic", "neurons", "a", "result", "of", "an", "antecedent", "C0042769#ent", "<e1>", "ultimately", "to", "the", "development", "of", "C0028754#ent", "<e2>"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [23, 24]}}
{"token": ["Although", "most", "childhood", "C0268732#ent", "<e1>", "to", "steroid", "treatment", ",", "C0403397#ent", "<e2>", "SRNS", ")", "is", "also", "common", "and", "is", "particularly", "difficult", "to", "treat", "."], "h": {"id": "C0268732", "name": "C0268732#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0403397", "name": "C0403397#ent", "pos": [9, 10]}}
{"token": ["On", "the", "other", "hand", ",", "none", "in", "the", "late", "death", "group", "died", "of", "C1145670#ent", "<e1>", "4", "patients", "died", "of", "chronic", "heart", "C0264490#ent", "<e2>", "4", "patients", "died", "in", "emarciation", "state", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [21, 22]}}
{"token": ["Taken", "together", ",", "these", "results", "suggest", "that", "the", "C1705791#ent", "<e1>", "MAP", "kinase", "essential", "for", "MMP-9", "upregulation", "via", "C3539645#ent", "<e2>", "and", "cytokine", "pathways", "astrocytes", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [17, 18]}}
{"token": ["C1442484#ent", "<e1>", "occurred", "in", "1", "of", "the", "23", "C2348923#ent", "<e2>", "sera", "tested", ",", "and", "CDI", "was", "observed", "in", "6", "out", "of", "the", "22", "patients", "tested", "."], "h": {"id": "C1442484", "name": "C1442484#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2348923", "name": "C2348923#ent", "pos": [8, 9]}}
{"token": ["Thallium", "intoxication", "characterized", "by", "the", "development", "of", "painful", "peripheral", "neuropathy", "C0002170#ent", "<e1>", ",", "mental", "disorders", "and", "in", "severe", "cases", ",", "C1145670#ent", "<e2>", "death", "."], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [20, 21]}}
{"token": ["The", "effects", "of", "new", "C0282555#ent", "<e1>", "azelastine", ",", "on", "allergen-", "and", "C0004099#ent", "<e2>", "studied", "."], "h": {"id": "C0282555", "name": "C0282555#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "phage", "K", "the", "potential", "to", "encode", "proteins", "necessary", "for", "its", "own", "replisome", ",", "including", "DNA", "ligase", "C0058594#ent", "<e1>", ",", "helicase", ",", "polymerase", ",", "C0014241#ent", "<e2>", "and", "DNA", "binding", "proteins"], "h": {"id": "C0058594", "name": "C0058594#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0014241", "name": "C0014241#ent", "pos": [26, 27]}}
{"token": ["We", "evaluated", "oligoclonal", "IgG", "band", "OCB", ")", "patterns", "obtained", "by", "analyzing", "paired", "cerebrospinal", "fluid", "C3889436#ent", "<e1>", ")", "and", "serum", "samples", "of", "77", "patients", "with", "C0014059#ent", "<e2>", "ADEM", ")", "and", "411", "patients", "with", "multiple", "sclerosis", "MS", ")", "."], "h": {"id": "C3889436", "name": "C3889436#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014059", "name": "C0014059#ent", "pos": [24, 25]}}
{"token": ["External", "C0393750#ent", "<e1>", "fever", "headache", "C0018681#ent", "<e2>", "associated", "with", "metabolic", "disorders", "and", "C0018681#ent", "<e2>", "associated", "with", "disorders", "of", "nose", "or", "sinuses", "all", "showed", "significant", "female", "preponderance", "."], "h": {"id": "C0393750", "name": "C0393750#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [5, 6]}}
{"token": ["To", "test", "at", "the", "population", "level", "whether", "people", "with", "C0524620#ent", "<e1>", "MMS", ")", "disorders", "have", "reduced", "cardiac", "autonomic", "activity", "(", "C1842937#ent", "<e2>", ")", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1842937", "name": "C1842937#ent", "pos": [20, 21]}}
{"token": ["Enteroviruses", "are", "common", "human", "viruses", "associated", "with", "clinical", "syndromes", "from", "minor", "febrile", "illness", "to", "severe", ",", "potentially", "fatal", "conditions", "(", "e.g.", ",", "C0025290#ent", "<e1>", "paralysis", ",", "myocarditis", ",", "and", "neonatal", "C0042749#ent", "<e2>", "."], "h": {"id": "C0025290", "name": "C0025290#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0042749", "name": "C0042749#ent", "pos": [30, 31]}}
{"token": ["Gels", "with", "C0033218#ent", "<e1>", "salified", "with", "the", "carboxyvinylic", "polymer", "had", "a", "faster", "release", "rate", "than", "those", "with", "C0033218#ent", "<e1>", "in", "the", "C0546849#ent", "<e1>", "form", "dissolved", "in", "the", "aqueous", "phase"], "h": {"id": "C0033218", "name": "C0033218#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [21, 22]}}
{"token": ["We", "also", "showed", "that", "angiocidin", "activated", "up-stream", "mediators", "of", "NF-kappaB", ",", "such", "as", "the", "C0170168#ent", "<e1>", "MAPK", ")", "pathway", "and", "phosphoinositide-3", "kinase", "C1705590#ent", "<e2>", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [22, 23]}}
{"token": ["The", "C2004456#ent", "<e1>", "form", "of", "C0041296#ent", "<e2>", "a", "very", "rare", "disease", "characterized", "by", "tumor-like", "tuberculomas", "abscesses", "."], "h": {"id": "C2004456", "name": "C2004456#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [5, 6]}}
{"token": ["C0343900#ent", "<e1>", "present", "with", "C0029166#ent", "<e2>", "often", "mimic", "carcinoma", "or", "tuberculosis", "."], "h": {"id": "C0343900", "name": "C0343900#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [4, 5]}}
{"token": ["RANK", "can", "interact", "with", "several", "TNF-receptor-associated", "factors", "C0795907#ent", "<e1>", ")", "and", "activates", "signaling", "molecules", "C0164786#ent", "<e2>", ",", "NF-kappaB", ",", "and", "MAPKs", "."], "h": {"id": "C0795907", "name": "C0795907#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [14, 15]}}
{"token": ["C1456396#ent", "<e1>", "may", "function", "as", "a", "modulator", "of", "C1420089#ent", "<e2>", "activity", "and", "play", "a", "role", "in", "Fe(III)", "uptake", ",", "possibly", "by", "affecting", "the", "number", "or", "affinity", "of", "citrate", "binding", "sites"], "h": {"id": "C1456396", "name": "C1456396#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420089", "name": "C1420089#ent", "pos": [8, 9]}}
{"token": ["However", ",", "in", "medullar", "tissue", "both", "Prohepcidin", "and", "C1456396#ent", "<e1>", "decreased", "and", "C1420089#ent", "<e2>", "was", "detected", "mainly", "in", "larger", "diameter", "tubules", "."], "h": {"id": "C1456396", "name": "C1456396#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420089", "name": "C1420089#ent", "pos": [12, 13]}}
{"token": ["Whereas", "chronic", "ibuprofen", "suppressed", "inflammation", "and", "plaque-related", "pathology", "in", "an", "C0078939#ent", "<e1>", "transgenic", "APPSw", "mouse", "model", "Tg2576", ")", ",", "excessive", "use", "of", "C0003211#ent", "<e2>", "targeting", "cyclooxygenase", "I", "cause", "gastrointestinal", ",", "liver", ",", "and", "renal", "toxicity"], "h": {"id": "C0078939", "name": "C0078939#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [22, 23]}}
{"token": ["The", "high", "bioavailability", "of", "C1413043#ent", "<e1>", "+", "fram", "milk", "dairy", "products", "been", "attributed", "to", "the", "production", "of", "C1840061#ent", "<e2>", "which", "are", "produced", "following", "digestion", "of", "casein", "by", "the", "action", "of", "gastrointestinal", "proteinases"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1840061", "name": "C1840061#ent", "pos": [17, 18]}}
{"token": ["A", "combination", "of", "C0165603#ent", "<e1>", "and", "clindamycin", "was", "more", "effective", "than", "C0165603#ent", "<e1>", "alone", "in", "the", "treatment", "of", "both", "acute", "and", "C0151317#ent", "<e1>", "failed", "to", "eliminate", "parasites", "completely", "."], "h": {"id": "C0165603", "name": "C0165603#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0151317", "name": "C0151317#ent", "pos": [21, 22]}}
{"token": ["A", "patient", "with", "C0398689#ent", "<e1>", ",", "we", "experienced", ",", "suffered", "from", "recurrent", "infections", "C0027947#ent", "<e2>", "."], "h": {"id": "C0398689", "name": "C0398689#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [13, 14]}}
{"token": ["Consider", "C0398689#ent", "<e1>", "a", "male", "child", "with", "recurrent", "bacterial", "or", "opportunistic", "infections", "C0027947#ent", "<e2>", ",", "hypogammaglobulinaemia", "(", "IgG", "and", "IgA", ")", "and", "normal", "T-", "and", "B-cell", "counts"], "h": {"id": "C0398689", "name": "C0398689#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [12, 13]}}
{"token": ["Consistent", "arterial", "reflow", "required", "0.063", "mg/kg", "of", "C0250239#ent", "<e1>", "and", "0.5", "mg/kg", "of", "C0032143#ent", "<e2>", "or", "of", "rscu-PA", "."], "h": {"id": "C0250239", "name": "C0250239#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [13, 14]}}
{"token": ["Neutral", "endopeptidase", "24.11", "C1366499#ent", "<e1>", ")", "cleaves", "kinins", "as", "effectively", "as", "C0003766#ent", "<e2>", "kininase", "II"], "h": {"id": "C1366499", "name": "C1366499#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003766", "name": "C0003766#ent", "pos": [11, 12]}}
{"token": ["In", "In", "vitro", "assay", ",", "Cdk5", "phosphorylated", "C1414145#ent", "<e1>", "at", "Ser522", ",", "while", "C1423043#ent", "<e2>", "did", "not", "induce", "any", "phosphorylation", "of", "C1414145#ent", "<e1>", "."], "h": {"id": "C1414145", "name": "C1414145#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423043", "name": "C1423043#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "Cdk5", "primarily", "phosphorylates", "C1414145#ent", "<e1>", "at", "Ser522", "and", "C1423043#ent", "<e2>", "secondarily", "phosphorylates", "at", "Thr509", "."], "h": {"id": "C1414145", "name": "C1414145#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423043", "name": "C1423043#ent", "pos": [12, 13]}}
{"token": ["Arava", "(", "C0063041#ent", "<e1>", ")", "is", "the", "first", "new", "disease", "modifying", "C0003191#ent", "<e2>", "DMARD", ")", "to", "be", "introduced", "in", "the", "UK", "for", "over", "a", "decade", "."], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [2, 3]}, "relation": "has_therapeutic_class", "t": {"id": "C0003191", "name": "C0003191#ent", "pos": [11, 12]}}
{"token": ["C0063041#ent", "<e1>", "is", "the", "prodrug", "of", "the", "disease", "modifying", "C0003191#ent", "<e2>", "A77", "1726"], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003191", "name": "C0003191#ent", "pos": [9, 10]}}
{"token": ["Further", "indications", "are", "polyposis", "syndromes", "suspected", "C0010346#ent", "<e1>", "malignomas", "of", "the", "C0341268#ent", "<e2>"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0341268", "name": "C0341268#ent", "pos": [11, 12]}}
{"token": ["In", "some", "contrast", "with", "this", "compartment-specific", "phosphorylation", "of", "c-Jun", ",", "immunocomplex", "assays", "revealed", "that", "the", "C1705632#ent", "<e1>", "activity", "was", "strongly", "enhanced", "in", "both", "C0002707#ent", "<e2>", "and", "hippocampus", "."], "h": {"id": "C1705632", "name": "C1705632#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002707", "name": "C0002707#ent", "pos": [23, 24]}}
{"token": ["We", "have", "screened", "peripheral", "blood", "DNA", "42", "AA", "patients", "and", "15", "C3889380#ent", "<e1>", "patients", "for", "the", "presence", "of", "C0809246#ent", "<e2>", "point", "mutations", "."], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0809246", "name": "C0809246#ent", "pos": [18, 19]}}
{"token": ["This", "deletion", "is", "predicted", "to", "produce", "a", "C1564139#ent", "<e1>", "a", "frameshift", "of", "its", "terminal", "41", "amino", "acids", "35", "C3539947#ent", "<e2>", "than", "the", "wild-type", "keratin", "5", "protein", "due", "to", "a", "delayed", "termination", "codon"], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [18, 19]}}
{"token": ["C1564139#ent", "<e1>", "the", "last", "four", "C3539947#ent", "<e2>", "the", "carboxy", "terminus", "the", "70-amino-acid", "mature", "SLT-II", "B", "polypeptide", "had", "no", "cytotoxic", "activity"], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [5, 6]}}
{"token": ["Septo-optic-pituitary", "dysplasia", "a", "C1848862#ent", "<e1>", "characterized", "by", "abnormalities", "of", "midline", "brain", "structures", ",", "C0338502#ent", "<e2>", "and", "congenital", "hypothalamic-pituitary", "insufficiency"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0338502", "name": "C0338502#ent", "pos": [13, 14]}}
{"token": ["The", "C1848862#ent", "<e1>", "of", "septo-optic", "dysplasia", "congenital", "hypopituitarism", "of", "C0338502#ent", "<e2>", "midline", "malformations", "the", "prosencephalon", "and", "hypothalamic", "hypopituitarism"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0338502", "name": "C0338502#ent", "pos": [9, 10]}}
{"token": ["Using", "isogenic", "Saccharomyces", "cerevisiae", "strains", "disrupted", "for", "a", "variety", "of", "C1417823#ent", "<e1>", "and", "BER", "C1417679#ent", "<e2>", "we", "have", "examined", "the", "relative", "importance", "of", "the", "two", "pathways", "in", "the", "repair", "of", "nitrogen", "mustard", "."], "h": {"id": "C1417823", "name": "C1417823#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}}
{"token": ["Increased", "opioidergic", "neurotransmission", "the", "brain", "appears", "to", "contribute", "to", "the", "pruritus", "that", "complicates", "C0008370#ent", "<e1>", "and", "certain", "non-cholestatic", "C0341439#ent", "<e2>"], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0341439", "name": "C0341439#ent", "pos": [18, 19]}}
{"token": ["One", "of", "the", "properties", "of", "C1335536#ent", "<e1>", "that", "allows", "one", "to", "distinguish", "them", "from", "other", "C1335550#ent", "<e2>", "their", "sensitivity", "to", "inhibition", "by", "two", "proteins", ",", "termed", "inhibitor", "1", "inhibitor", "2", "or", "modulator", "."], "h": {"id": "C1335536", "name": "C1335536#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335550", "name": "C1335550#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", "basal", "GFR", "is", "related", "to", "renal", "volume", "Tx", "and", "that", "the", "response", "to", "C0002514#ent", "<e1>", "seems", "to", "be", "affected", "by", "chronic", "C0010592#ent", "<e2>", "administration", "."], "h": {"id": "C0002514", "name": "C0002514#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [24, 25]}}
{"token": ["In", "C1412726#ent", "<e1>", ",", "the", "drug", "treatment", "in", "depression", "of", "C0015683#ent", "<e2>", "ATP-citrate", "lyase", "malic", "enzyme", "glucose", "6-phosphate", "dehydrogenase", "6-phosphogluconate", "dehydrogenase", "activities", "."], "h": {"id": "C1412726", "name": "C1412726#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015683", "name": "C0015683#ent", "pos": [10, 11]}}
{"token": ["The", "stimulation", "of", "C0001492#ent", "<e1>", "cholera", "toxin", "CT", ")", "was", "studied", "in", "normal", "and", "C0162429#ent", "<e2>", "rats", "4", "to", "24", "hr", "after", "a", "30-min", "incubation", "of", "intestinal", "loops", "the", "toxin", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [14, 15]}}
{"token": ["Cytotoxic", "T", "cells", "recognize", "and", "kill", "tumor", "cells", "present", "C0030956#ent", "<e1>", "derived", "from", "tumor-associated", "antigens", "C0003486#ent", "<e2>", ")", "on", "their", "surface", "when", "associated", "with", "histocompatibility", "complex", "MHC", ")", "class", "I", "molecules"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [15, 16]}}
{"token": ["Purified", "P.", "carinii", "C1134651#ent", "<e1>", "predictably", "induce", "both", "C1333196#ent", "<e2>", "associated", "neutrophilic", "lung", "inflammation"], "h": {"id": "C1134651", "name": "C1134651#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "circulating", "C1134651#ent", "<e1>", "may", "prevent", "C1333196#ent", "<e2>", "upregulation", "in", "response", "to", "infection", "."], "h": {"id": "C1134651", "name": "C1134651#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [8, 9]}}
{"token": ["We", "show", "that", "MbIII", "is", "important", "for", "repression", "of", "these", "genes", "and", "present", "evidence", "that", "this", "element", "contributes", "to", "repression", "by", "recruiting", "the", "histone", "deacetylase", "C1098658#ent", "<e1>", "to", "the", "C1334077#ent", "<e2>", "and", "Gadd153", "promoters"], "h": {"id": "C1098658", "name": "C1098658#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1334077", "name": "C1334077#ent", "pos": [29, 30]}}
{"token": ["Also", ",", "conditioned", "medium", "the", "bladder", "carcinoma", "cell", "line", "5637", ",", "which", "is", "used", "routinely", "as", "a", "source", "of", "C1332791#ent", "<e1>", "GM-CSF", ")", ",", "contains", "approximately", "4", "ng/ml", "C1334122#ent", "<e2>", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1334122", "name": "C1334122#ent", "pos": [28, 29]}}
{"token": ["Anthelmintic", "therapies", "C0086227#ent", "<e1>", "are", "successful", "and", "include", "mebendazole", ",", "albendazole", "and", "C0034237#ent", "<e2>"], "h": {"id": "C0086227", "name": "C0086227#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0034237", "name": "C0034237#ent", "pos": [12, 13]}}
{"token": ["No", "differences", "were", "observed", "in", "the", "expression", "of", "IGF-II", ",", "C0123707#ent", "<e1>", "and", "-6", "and", "IGF-IR", "throughout", "the", "lifespan", "of", "the", "C0010093#ent", "<e2>"], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010093", "name": "C0010093#ent", "pos": [21, 22]}}
{"token": ["Human", "C8", "is", "composed", "of", "three", "nonidentical", "subunits", "(", "C8", "alpha", "C1413024#ent", "<e1>", "and", "C8", "gamma", ")", "that", "are", "encoded", "in", "separate", "C1417679#ent", "<e2>", "."], "h": {"id": "C1413024", "name": "C1413024#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [22, 23]}}
{"token": ["We", "have", "previously", "shown", "that", "C1332716#ent", "<e1>", "is", "phosphorylated", "and", "recruits", "SH2-containing", "tyrosine", "phosphatase-1", "cross-linking", "of", "the", "Ag", "receptor", "of", "B", "cells", "C0105421#ent", "<e2>", ")", "."], "h": {"id": "C1332716", "name": "C1332716#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "C1332716#ent", "<e1>", "appears", "to", "exert", "a", "positive", "effect", "on", "C0105421#ent", "<e2>", "signaling", "pathways", "to", "Ca(2+)", "influx", "and", "MAPK", "activation", ",", "which", "in", "turn", "may", "determine", "the", "fate", "of", "BAL-17", "cells", "."], "h": {"id": "C1332716", "name": "C1332716#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [11, 12]}}
{"token": ["To", "study", "the", "generation", "of", "the", "hepatotoxin", "hydrazine", "32", "C0162429#ent", "<e1>", "children", "receiving", "isoniazid", "for", "the", "treatment", "of", "C0041318#ent", "<e2>"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041318", "name": "C0041318#ent", "pos": [18, 19]}}
{"token": ["In", "this", "issue", ",", "researchers", "describe", "a", "simple", "assay", "for", "the", "rapid", ",", "high-throughput", "identification", "novel", "C0035064#ent", "<e1>", "that", "promote", "degradation", "of", "the", "C0242957#ent", "<e2>", "EGFR", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [23, 24]}}
{"token": ["Among", "these", "C0035064#ent", "<e1>", ",", "Herceptin", "(", "trastuzumab", ")", ",", "a", "humanized", "C0242957#ent", "<e2>", "HER2/c-erbB2", ")", "monoclonal", "antibody", "has", "been", "used", "successfully", "in", "patients", "with", "breast", "cancer"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [12, 13]}}
{"token": ["Seven", "anthraquinones", ",", "together", "with", "C0053530#ent", "<e1>", "stigmasterol", "and", "C0037215#ent", "<e2>", "were", "isolated", "from", "the", "hairy", "roots"], "h": {"id": "C0053530", "name": "C0053530#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037215", "name": "C0037215#ent", "pos": [9, 10]}}
{"token": ["Inhibitors", "of", "G(i)/G(o)", "protein", "phospholipase", "C", "C0031669#ent", "<e1>", ")", "and", "protein", "kinase", "Cdelta", "PKCdelta", ")", "inhibited", "the", "chemotactic", "activity", "C1332679#ent", "<e2>", "indicating", "that", "Lkn-1-induced", "chemotaxis", "signal", "transduced", "through", "G(i)/G(o)", "protein", "C0031669#ent", "<e1>", "and", "PKCdelta", "."], "h": {"id": "C1332679", "name": "C1332679#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", "C1332679#ent", "<e1>", "transduces", "the", "signal", "through", "G(i)/G(o)", "protein", "C0031669#ent", "<e2>", ",", "PKCdelta", ",", "NF-kappaB", "and", "newly", "synthesized", "proteins", "for", "chemotaxis", "."], "h": {"id": "C1332679", "name": "C1332679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [12, 13]}}
{"token": ["These", "results", "showed", "the", "-2518", "C1705079#ent", "<e1>", "polymorphism", "is", "related", "to", "the", "susceptibility", "of", "plaque", "type", "C0033860#ent", "<e2>", "."], "h": {"id": "C1705079", "name": "C1705079#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [16, 17]}}
{"token": ["C0034861#ent", "<e1>", "synthesized", "as", "an", "C0014159#ent", "<e2>", "Endo", "H)-sensitive", "glycoprotein", "with", "high", "mannose", "simple", "oligosaccharides", "gp", "190", ")", "that", "underwent", "post-translational", "modification", "an", "Endo", "H-resistant", "glycoprotein", "with", "complex", "oligosaccharides", "gp210", ")", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014159", "name": "C0014159#ent", "pos": [5, 6]}}
{"token": ["Measurement", "of", "salivary", "clearance", "urinary", "metabolites", "caffeine", "is", "an", "excellent", "noninvasive", "tool", "assessing", "liver", "function", "particularly", "the", "activity", "of", "C0207509#ent", "<e1>", "CYP1A2", ")", ",", "N-acetyltransferase", "(", "NAT", ")", ",", "and", "C0043317#ent", "<e2>", "XO", ")", "."], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [30, 31]}}
{"token": ["Caffeine", "was", "used", "as", "a", "metabolic", "probe", "screen", "healthy", "subjects", "their", "activities", "of", "two", "enzymes", ",", "deduced", "to", "be", "C0207509#ent", "<e1>", "(", "an", "inducible", "cytochrome", "P450", "and", "C0043317#ent", "<e2>"], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [27, 28]}}
{"token": ["Neither", "the", "C0207509#ent", "<e1>", "nor", "the", "C0043317#ent", "<e2>", "between", "volunteers", "of", "Chinese", "and", "European", "extraction"], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [6, 7]}}
{"token": ["To", "assess", "the", "effect", "of", "gender", ",", "age", ",", "and", "smoking", "habits", "the", "in", "vivo", "activities", "of", "C0207509#ent", "<e1>", ",", "flavin-containing", "monooxygenase", "FMO", ")", ",", "and", "C0043317#ent", "<e2>", "Korean", "subjects", "."], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [26, 27]}}
{"token": ["An", "uncontrolled", "case", "series", "assembled", "to", "evaluate", "the", "efficacy", "of", "the", "intravitreal", "ganciclovir", "implant", "for", "patients", "with", "sight-threatening", "C0010823#ent", "<e1>", "had", "previously", "failed", "to", "respond", "to", "intravenous", "ganciclovir", "and/or", "C0070895#ent", "<e2>", "."], "h": {"id": "C0010823", "name": "C0010823#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0070895", "name": "C0070895#ent", "pos": [29, 30]}}
{"token": ["Blood", "and", "urine", "for", "CMV", "culture", "were", "obtained", "from", "207", "patients", "with", "newly", "diagnosed", "C0010823#ent", "<e1>", "were", "enrolled", "in", "a", "randomized", "trial", "C0070895#ent", "<e2>", "and", "ganciclovir", "."], "h": {"id": "C0010823", "name": "C0010823#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0070895", "name": "C0070895#ent", "pos": [22, 23]}}
{"token": ["Cytogenetic", "and", "molecular", "analysis", "ecdysone", "response", "in", "Drosophila", "larval", "C0036091#ent", "<e1>", "revealed", "regulatory", "hierarchies", "early", "C1417679#ent", "<e2>", "which", "encode", "transcription", "factors", "late", "ecdysone", "response", "."], "h": {"id": "C0036091", "name": "C0036091#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["A", "C0003211#ent", "<e1>", "phenylbutazone", ",", "and", "an", "C0003404#ent", "<e2>", "ivermectin", ",", "were", "tested", "in", "the", "model", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003404", "name": "C0003404#ent", "pos": [7, 8]}}
{"token": ["Therefore", ",", "we", "propose", "that", "haploinsufficiency", "of", "the", "CMO1", "enzyme", "may", "cause", "symptoms", "of", "hypercarotenemia", "and", "C0376286#ent", "<e1>", "A", "in", "individuals", "consuming", "a", "C1425257#ent", "<e2>", "and", "vitamin", "A-deficient", "diet", "."], "h": {"id": "C0376286", "name": "C0376286#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1425257", "name": "C1425257#ent", "pos": [23, 24]}}
{"token": ["Charcot-Marie-Tooth", "disease", "classified", "into", "hereditary", "motor", "C0699739#ent", "<e1>", "HMSN", ")", "types", "I", "and", "C3273406#ent", "<e2>", ",", "and", "affected", "patients", "present", "with", "progressive", "peripheral", "neuropathy"], "h": {"id": "C0699739", "name": "C0699739#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [13, 14]}}
{"token": ["In", "summary", ",", "C0017628#ent", "<e1>", "showed", "potent", "inhibition", "on", "C0608437#ent", "<e2>", "and", "weak", "inhibition", "on", "CYP3A4", ",", "whereas", "it", "had", "minimal", "or", "no", "inhibitory", "effect", "on", "the", "other", "cytochromes", "p450", "."], "h": {"id": "C0017628", "name": "C0017628#ent", "pos": [3, 4]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [9, 10]}}
{"token": ["Genes", "that", "could", "potentially", "be", "involved", "in", "the", "formation", "of", "the", "C0010964#ent", "<e1>", "phenotype", "are", "transcription", "factors", "C0017337#ent", "<e2>", "responsible", "for", "the", "regulation", "of", "normal", "in", "particular", "cerebral", "development", "also", "adhesion", "molecules"], "h": {"id": "C0010964", "name": "C0010964#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}}
{"token": ["C0085542#ent", "<e1>", "is", "a", "new", "potent", "cholesterol-lowering", "agent", "which", "selectively", "inhibits", "C0020374#ent", "<e2>"], "h": {"id": "C0085542", "name": "C0085542#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [11, 12]}}
{"token": ["Coexpression", "of", "retinoid", "X", "receptor", "RXR", ")", ",", "a", "C1334896#ent", "<e1>", "and", "its", "ligand", "9-cis-retinoic", "acid", "synergistically", "activated", "the", "C1420398#ent", "<e2>", "promoter", "."], "h": {"id": "C1334896", "name": "C1334896#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420398", "name": "C1420398#ent", "pos": [19, 20]}}
{"token": ["TPA", "and", "C1414260#ent", "<e1>", "were", "the", "most", "potent", "activators", "of", "c-Raf", "and", "C3853563#ent", "<e2>", "."], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3853563", "name": "C3853563#ent", "pos": [12, 13]}}
{"token": ["Carbamazepine", "(", "C0006949#ent", "<e1>", ")", "undergoes", "biotransformation", "by", "C1142644#ent", "<e2>", "and", "CYP2C8", ",", "and", "glucuronide", "conjugation"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [8, 9]}}
{"token": ["Specific", "covalent", "binding", "to", "yeasts", "expressing", "different", "P450s", "showed", "that", "C0006949#ent", "<e1>", "reactive", "metabolites", "bound", "specifically", "to", "P450", "1A2", "C1142644#ent", "<e2>", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [10, 11]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [19, 20]}}
{"token": ["These", "cDNAs", "encode", "one", "unique", "protein", "(", "C2984530#ent", "<e1>", ")", "containing", "zinc", "fingers", "domains", "characteristic", "of", "C1419989#ent", "<e2>", "RNA", "binding", "proteins"], "h": {"id": "C2984530", "name": "C2984530#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419989", "name": "C1419989#ent", "pos": [16, 17]}}
{"token": ["We", "implanted", "osmotic", "minipumps", "which", "infused", "10", "micrograms/kg/min", "of", "C0282210#ent", "<e1>", ",", "10", "micrograms/kg/min", "of", "terbutaline", "or", "0.2", "microgram/kg/min", "of", "C0033497#ent", "<e2>", "into", "the", "s.c", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [20, 21]}}
{"token": ["The", "effect", "of", "C0282210#ent", "<e1>", "was", "abolished", "by", "C0033497#ent", "<e2>", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [8, 9]}}
{"token": ["Characterization", "of", "several", "tk+", "transformants", "revealed", "that", "these", "cells", "did", "contain", "the", "C1336633#ent", "<e1>", "but", "in", "none", "of", "these", "cells", "could", "Ad5", "C1413924#ent", "<e2>", "DNA", "sequences", "detected", "."], "h": {"id": "C1336633", "name": "C1336633#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413924", "name": "C1413924#ent", "pos": [22, 23]}}
{"token": ["The", "common", "rapid", "(", "C1705514#ent", "<e1>", "and", "slow", "(", "NAT2", "*", "5B", ")", "acetylator", "human", "C1421999#ent", "<e2>", "alleles", "were", "also", "characterized", "for", "comparison", "."], "h": {"id": "C1705514", "name": "C1705514#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421999", "name": "C1421999#ent", "pos": [15, 16]}}
{"token": ["The", "two", "functional", "genes", "AAC1", "and", "C1705514#ent", "<e1>", "alias", "NAT1", "and", "C1421999#ent", "<e2>", ")", "without", "introns", "in", "the", "coding", "region", "encode", "enzymes", "which", "metabolise", "carcinogens", ",", "including", "bladder", "carcinogens"], "h": {"id": "C1705514", "name": "C1705514#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421999", "name": "C1421999#ent", "pos": [11, 12]}}
{"token": ["The", "present", "study", "was", "aimed", "at", "exploring", "the", "possibility", "that", "the", "structure-activity", "observations", "in", "the", "C0005034#ent", "<e1>", "series", "of", "C0013036#ent", "<e2>", "be", "extrapolated", "to", "another", "class", "of", "dopamine", "receptor", "agonists", "the", "2-aminotetralins", "."], "h": {"id": "C0005034", "name": "C0005034#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013036", "name": "C0013036#ent", "pos": [19, 20]}}
{"token": ["Increases", "in", "growth", "and", "transcription", "factor", "genes", "JNK-1", ",", "cyclic", "AMP", "response", "element", "binding", "protein", "CREB", ")", ",", "and", "C0694895#ent", "<e1>", "mRNAs", "and", "decreases", "included", "insulin-like", "growth", "factor-1", "IGF-1", ")", ",", "transforming", "growth", "factor", "beta-3", "C1710291#ent", "<e2>", ")", ",", "and", "NFkB", "mRNAs", "."], "h": {"id": "C0694895", "name": "C0694895#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1710291", "name": "C1710291#ent", "pos": [35, 36]}}
{"token": ["To", "determine", "whether", "over", "the", "C2963161#ent", "<e1>", "effective", "for", "C0010200#ent", "<e2>", "adults", "."], "h": {"id": "C2963161", "name": "C2963161#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [9, 10]}}
{"token": ["It", "differs", "from", "C1334706#ent", "<e1>", "such", "as", "C3887624#ent", "<e2>", "and", "kidney", "brush-border", "protease", "its", "failure", "to", "be", "strongly", "inhibited", "by", "phosphoramidon", "and", "Zincov", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [7, 8]}}
{"token": ["After", "C0033497#ent", "<e1>", "treatment", ",", "the", "values", "of", "LF", "and", "C1538440#ent", "<e2>", "power", "during", "the", "day", "were", "comparable", "to", "those", "recorded", "at", "night", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "the", "GDD1", "gene", "C0011989#ent", "<e1>", "a", "rare", "human", "skeletal", "syndrome", "C2936739#ent", "<e2>", "inheritance", "."], "h": {"id": "C0011989", "name": "C0011989#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [12, 13]}}
{"token": ["C0011989#ent", "<e1>", "PDD", ")", "is", "a", "rare", ",", "C2936739#ent", "<e2>", "osteosclerotic", "dysplasia", "affecting", "both", "endochondrally", "and", "intramembranously", "derived", "bones", "."], "h": {"id": "C0011989", "name": "C0011989#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "show", "that", "mixing", "NK", "cells", "insect", "cells", "expressing", "HLA-C", "was", "sufficient", "to", "induce", "clustering", "of", "C3540490#ent", "<e1>", ",", "and", "phosphorylation", "of", "C3540490#ent", "<e1>", "and", "C1705637#ent", "<e1>", "."], "h": {"id": "C3540490", "name": "C3540490#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705637", "name": "C1705637#ent", "pos": [26, 27]}}
{"token": ["In", "this", "complex", ",", "C1824797#ent", "<e1>", "serves", "the", "role", "of", "helper", "protein", "while", "C1426160#ent", "<e2>", "provides", "the", "enzymatic", "activity", "the", "modification", "."], "h": {"id": "C1824797", "name": "C1824797#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1426160", "name": "C1426160#ent", "pos": [13, 14]}}
{"token": ["The", "threshold", "concentration", "of", "cyclin", "and", "the", "length", "of", "the", "lag", "period", "are", "regulated", "by", "INH", ",", "an", "inhibitor", "of", "C0079805#ent", "<e1>", "activation", "in", "oocytes", "recently", "identified", "as", "a", "C1704708#ent", "<e2>"], "h": {"id": "C0079805", "name": "C0079805#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [29, 30]}}
{"token": ["Many", "signaling", "molecules", "formed", "complexes", "with", "the", "activated", "EGFR-Shc", ",", "as", "did", "plectin", ",", "epiplakin", ",", "cytokeratin", "networks", "C3829685#ent", "<e1>", "the", "glycosylphosphatidylinositol", "(GPI)-anchored", "molecule", "CD59", ",", "and", "two", "novel", "C0086376#ent", "<e2>", "."], "h": {"id": "C3829685", "name": "C3829685#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [29, 30]}}
{"token": ["The", "use", "of", "kinase", "inhibitors", "that", "phosphorylation", "of", "C3829685#ent", "<e1>", "be", "uncoupled", "from", "meiotic", "chromosome", "condensation", "therefore", "other", "C0086376#ent", "<e2>", ",", "such", "as", "those", "constituting", "metaphase-promoting", "factor", "must", "be", "involved", "."], "h": {"id": "C3829685", "name": "C3829685#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [18, 19]}}
{"token": ["The", "C0015397#ent", "<e1>", "lead", "to", "blindness", "from", "C0035305#ent", "<e2>", "there", "is", "often", "associated", "hearing", "loss"], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0035305", "name": "C0035305#ent", "pos": [7, 8]}}
{"token": ["C0969679#ent", "<e1>", "a", "two-headed", "molecular", "motor", "that", "binds", "six", "C0238239#ent", "<e2>", "heavy", "chain", ",", "which", "creates", "unusually", "long", "lever", "arms", "."], "h": {"id": "C0969679", "name": "C0969679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0238239", "name": "C0238239#ent", "pos": [9, 10]}}
{"token": ["The", "depression", "of", "the", "phase-transition", "temperature", "of", "dimyristoyl-", "and", "C0216971#ent", "<e1>", "vesicles", "induced", "by", "C0031428#ent", "<e2>", "has", "been", "investigated", "by", "fluorescence", "polarization"], "h": {"id": "C0216971", "name": "C0216971#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [14, 15]}}
{"token": ["We", "compared", "C1413933#ent", "<e1>", "with", "GAT", "in", "C0235267#ent", "<e2>", "with", "normal", "corneas", "various", "thickness", "."], "h": {"id": "C1413933", "name": "C1413933#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [7, 8]}}
{"token": ["To", "compare", "the", "performance", "of", "dynamic", "contour", "tonometry", "(", "C1413933#ent", "<e1>", ")", "and", "Goldmann", "applanation", "tonometry", "GAT", ")", "in", "measuring", "intraocular", "pressure", "C0235267#ent", "<e2>", "with", "irregular", "corneas"], "h": {"id": "C1413933", "name": "C1413933#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [22, 23]}}
{"token": ["Thiazolidinediones", "increase", "adiponectin", "concentrations", ",", "improve", "insulin", "sensitivity", "C0015695#ent", "<e1>", "reflected", "by", "decreased", "C0001899#ent", "<e2>", "ALT", "]", "activity", ")", "in", "type", "2", "diabetes"], "h": {"id": "C0015695", "name": "C0015695#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001899", "name": "C0001899#ent", "pos": [13, 14]}}
{"token": ["Compared", "to", "the", "healthy", "controls", "both", "groups", "with", "C0015695#ent", "<e1>", "significantly", "higher", "serum", "C0001899#ent", "<e2>", ",", "hepatic", "mitochondrial", "H(2)O(2", ")", "production", ",", "and", "hepatocyte", "oxidative", "DNA", "damage"], "h": {"id": "C0015695", "name": "C0015695#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001899", "name": "C0001899#ent", "pos": [13, 14]}}
{"token": ["Although", "C0013617#ent", "<e1>", "does", "not", "alter", "plasma", "cholinesterase", "activity", ",", "we", "have", "observed", "that", "doses", "of", "C0013617#ent", "<e1>", "that", "antagonize", "paralysis", "from", "other", "C0010464#ent", "<e1>", "relaxants", "are", "less", "effective", "with", "mivacurium", "."], "h": {"id": "C0013617", "name": "C0013617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010464", "name": "C0010464#ent", "pos": [23, 24]}}
{"token": ["C0769218#ent", "<e1>", "is", "an", "epithelial-derived", ",", "C0036734#ent", "<e2>", "has", "been", "implicated", "in", "the", "progression", "of", "epithelial", "tumors"], "h": {"id": "C0769218", "name": "C0769218#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [6, 7]}}
{"token": ["In", "particular", "there", "is", "increased", "evidence", "for", "an", "association", "between", "acquired", "C1366370#ent", "<e1>", "interferon", "given", "as", "treatment", "for", "C4288963#ent", "<e2>"], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4288963", "name": "C4288963#ent", "pos": [18, 19]}}
{"token": ["We", "carried", "out", "an", "experimental", "study", "rabbit", "corneas", "were", "cryopreserved", "by", "using", "C0032857#ent", "<e1>", "(", "PVP", ")", "as", "C0010406#ent", "<e2>", "dimethylsulfoxide", "(", "DMSO", ")", "as", "the", "control", "."], "h": {"id": "C0032857", "name": "C0032857#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010406", "name": "C0010406#ent", "pos": [18, 19]}}
{"token": ["We", "suggest", "that", "p53", "has", "a", "role", "in", "C0287666#ent", "<e1>", "clearance", "post", "DSB", "repair", "and", "that", "C1417613#ent", "<e2>", "might", "be", "sites", "of", "RAD51", "protein", "degradation", "."], "h": {"id": "C0287666", "name": "C0287666#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "purified", "recombinant", "C0287666#ent", "<e1>", "associates", "with", "in", "vitro", "transcribed", "and", "translated", "C1417613#ent", "<e2>", "."], "h": {"id": "C0287666", "name": "C0287666#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [13, 14]}}
{"token": ["NADPH", "CYTOCHROME", "C", "REDUCTASE", "ACTIVITY", "EHANCED", "2.5-FOLD", ",", "C0028141#ent", "<e1>", ",", "benzpyrene", "hydroxylase", "2-fold", ",", "and", "C0026027#ent", "<e2>", "after", "treating", "rats", "with", "dieldrin", "for", "6", "days", "."], "h": {"id": "C0028141", "name": "C0028141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026027", "name": "C0026027#ent", "pos": [16, 17]}}
{"token": ["To", "examine", "the", "effects", "of", "intravesical", "cyclooxygenase-2", "COX-2", ")", "inhibitors", "on", "the", "expression", "of", "inducible", "nitric", "oxide", "synthase", "C0669372#ent", "<e1>", ")", "and", "nerve", "growth", "factor", "NGF", ")", "in", "C1161438#ent", "<e2>", "(CYP)-induced", "overactive", "bladder", "OAB", ")", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [28, 29]}}
{"token": ["It", "was", "previously", "shown", "that", "nitric", "oxide", "by", "C0669372#ent", "<e1>", "iNOS", ")", "and", "peroxynitrite", "are", "responsible", "for", "C1161438#ent", "<e2>", "(CP)-induced", "cystitis", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [17, 18]}}
{"token": ["Maternal", "C0669372#ent", "<e1>", "were", "necessary", "for", "the", "expression", "of", "C1161438#ent", "<e2>", "embryotoxicity", ",", "which", "was", "concentration-dependent", ",", "as", "demonstrated", "by", "increasing", "severity", "of", "reductions", "in", "crown", "rump", "length", "yolk", "sac", "diameter", "somite", "number"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [9, 10]}}
{"token": ["A", "21-year-old", "male", "presented", "with", "high", "fever", "sore", "throat", "C0231528#ent", "<e1>", "of", "1", "week", "C0720099#ent", "<e2>", "."], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [14, 15]}}
{"token": ["A", "17-year-old", "girl", "presented", "with", "malaise", ",", "weakness", ",", "palpitations", ",", "dysphagia", ",", "C0231528#ent", "<e1>", ",", "and", "weight", "loss", "1", "month", "'s", "C0720099#ent", "<e2>", "."], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [22, 23]}}
{"token": ["Akt/protein", "kinase", "B", ",", "a", "C0072402#ent", "<e1>", "is", "a", "key", "downstream", "effector", "of", "the", "C1705325#ent", "<e2>"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705325", "name": "C1705325#ent", "pos": [14, 15]}}
{"token": ["Although", "S6K", "phosphorylation", "is", "independent", "of", "phosphoinositide", "3-OH", "kinase", "C1705325#ent", "<e1>", "and", "C0072402#ent", "<e2>", "that", "of", "4E-BP", "is", "dependent", "on", "C1705325#ent", "<e1>", "Akt", "."], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705325", "name": "C1705325#ent", "pos": [9, 10]}}
{"token": ["Cytochrome", "c", "C1426584#ent", "<e1>", ")", "and", "9", "of", "the", "13", "subunits", "of", "C0010760#ent", "<e2>", "complex", "IV", "COX", ")", "were", "previously", "shown", "to", "have", "accelerated", "rates", "of", "nonsynonymous", "substitution", "anthropoid", "primates", "."], "h": {"id": "C1426584", "name": "C1426584#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010760", "name": "C0010760#ent", "pos": [12, 13]}}
{"token": ["This", "report", "presents", "a", "patient", "with", "late-onset", "TTR-Met", "30", "who", "primarily", "developed", "C0878544#ent", "<e1>", "with", "less", "C0206247#ent", "<e2>", "the", "peripheral", "nervous", "system", "is", "usually", "seen", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0206247", "name": "C0206247#ent", "pos": [16, 17]}}
{"token": ["The", "patient", "died", "from", "progressive", "C1145670#ent", "<e1>", "pulmonary", "hypertension", "signs", "of", "C2939447#ent", "<e2>"], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2939447", "name": "C2939447#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "the", "C1417544#ent", "<e1>", "Drosophila", ",", "which", "is", "encoded", "by", "the", "C0079686#ent", "<e2>", "appears", "to", "be", "similar", "to", "rabbit", "nonmuscle", "myosin-IIA", "."], "h": {"id": "C1417544", "name": "C1417544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079686", "name": "C0079686#ent", "pos": [12, 13]}}
{"token": ["Axonal", "floatation", "was", "used", "to", "C1875400#ent", "<e1>", "neurofilaments", "(", "NFs", ")", "and", "endogenous", "C0031727#ent", "<e2>", "from", "brains", "and", "spinal", "cords", "treated", "and", "control", "animals"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["Low", "concentrations", "of", "virus", "from", "the", "NPC-KT", "cell", "line", "stimulated", "DNA", "synthesis", "human", "cord", "blood", "lymphocytes", "C0008163#ent", "<e1>", ")", "and", "induced", "C0008163#ent", "<e1>", "to", "form", "C0149678#ent", "<e1>", "nuclear", "antigen-positive", "continuous", "cell", "lines", "."], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [25, 26]}}
{"token": ["Here", "we", "report", "that", "biochemical", "purification", "this", "protein", "revealed", "it", "as", "the", "human", "C1334043#ent", "<e1>", "of", "the", "C1305923#ent", "<e2>", "binds", "the", "Alu-homologous", "region", "of", "7SL", "RNA"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [17, 18]}}
{"token": ["We", "show", "that", "olfactory", "responses", "be", "mediated", "by", "a", "GTP-binding", "protein", "G", "protein", ",", "a", "C1334043#ent", "<e1>", "of", "the", "visual", ",", "hormonal", ",", "and", "brain", "signal", "transducing", "C1305923#ent", "<e2>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [27, 28]}}
{"token": ["To", "define", "further", "the", "substrate", "specificities", "of", "these", "C3541394#ent", "<e1>", ",", "a", "series", "of", "mutant", "C0071928#ent", "<e2>", "cDNAs", "were", "generated", "by", "site-directed", "and", "deletion", "mutagenesis", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0071928", "name": "C0071928#ent", "pos": [15, 16]}}
{"token": ["Four", "tarsorrhaphy", "sutures", "are", "placed", "through", "the", "lower", "eyelid", "brow", "following", "C0033377#ent", "<e1>", "a", "system", "designed", "for", "patients", "with", "external", "ophthalmoplegia", "third", "nerve", "paralysis", "and", "C0026896#ent", "<e2>"], "h": {"id": "C0033377", "name": "C0033377#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [25, 26]}}
{"token": ["Synaptogenic", "forms", "of", "C0033377#ent", "<e1>", "are", ":", "Botulism", "and", "C0026896#ent", "<e2>"], "h": {"id": "C0033377", "name": "C0033377#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "Bax", "is", "not", "absolutely", "required", "for", "death", "receptor", "apoptotic", "signals", "MG132", "by", "upregulating", "C1336644#ent", "<e1>", "effectively", "cooperates", "with", "C1522480#ent", "<e2>", "to", "overcome", "Bax", "deficiency-induced", "resistance", "to", "C1522480#ent", "<e2>", "."], "h": {"id": "C1336644", "name": "C1336644#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1522480", "name": "C1522480#ent", "pos": [22, 23]}}
{"token": ["Blocking", "of", "up-regulation", "of", "DR4", "and", "C1336644#ent", "<e1>", "alone", "significantly", "reduced", "cell", "death", "combined", "treatment", "with", "cardiac", "glycosides", "C1522480#ent", "<e2>", "."], "h": {"id": "C1336644", "name": "C1336644#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1522480", "name": "C1522480#ent", "pos": [18, 19]}}
{"token": ["C1442521#ent", "<e1>", "HGF", ")", "is", "a", "potent", "stimulator", "of", "DNA", "synthesis", "cultured", "C0669372#ent", "<e2>", "."], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "we", "show", "that", "C3812251#ent", "<e1>", "phosphorylation", "by", "C3849574#ent", "<e2>", "enhances", "thyroid", "hormone", "receptor-dependent", "transcription", "in", "vitro"], "h": {"id": "C3812251", "name": "C3812251#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [9, 10]}}
{"token": ["We", "show", "that", "C3812251#ent", "<e1>", "directly", "binds", "to", "the", "MED7", "subunit", "and", "that", "C3849574#ent", "<e2>", "phosphorylation", "of", "C3812251#ent", "<e1>", "enhances", "this", "interaction", "."], "h": {"id": "C3812251", "name": "C3812251#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [13, 14]}}
{"token": ["The", "expression", "of", "lymphoid", "cell", "markers", "on", "PBMC", "and", "splenocytes", "of", "mice", "homozygous", "for", "the", "mutation", "in", "C1425360#ent", "<e1>", "(", "2B4(-/-", ")", ")", "is", "identical", "to", "that", "in", "C2987364#ent", "<e2>"], "h": {"id": "C1425360", "name": "C1425360#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [28, 29]}}
{"token": ["The", "structure", "of", "the", "inhibitor", "was", "deduced", "to", "be", "C0072202#ent", "<e1>", "reported", "as", "an", "C3887624#ent", "<e2>"], "h": {"id": "C0072202", "name": "C0072202#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [14, 15]}}
{"token": ["C0008809#ent", "<e1>", "decreased", "IL-6", "mRNA", "(", "P<0.05", ")", "and", "increased", "C1366571#ent", "<e2>", "mRNA", "(", "P<0.05", ")", "expression", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [10, 11]}}
{"token": ["We", "therefore", "investigated", "the", "effect", "of", "C0008809#ent", "<e1>", "on", "mRNA", "for", "IL-6", "and", "C1366571#ent", "<e2>", ",", "and", "on", "three", "transcription", "factors", "to", "be", "involved", "in", "the", "regulation", "of", "these", "cytokines", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [13, 14]}}
{"token": ["Inclusion", "of", "100", "mM", "LiCl", "in", "intracellular", "recording", "electrodes", "shown", "to", "block", "postsynaptic", "G-proteins", "by", "bath-application", "of", "C0004609#ent", "<e1>", ",", "an", "agonist", "at", "the", "C0752065#ent", "<e2>", "linked", "gamma-aminobutyric", "acid", "GABAB", ")", "receptor", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0752065", "name": "C0752065#ent", "pos": [24, 25]}}
{"token": ["Patients", "with", "aspirin-induced", "changes", "renal", "function", "more", "likely", "to", "have", "C0022658#ent", "<e1>", "P", "=", "0.035", ")", "or", "C0853888#ent", "<e2>", "(", "P", "=", "0.030", ")", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0853888", "name": "C0853888#ent", "pos": [17, 18]}}
{"token": ["They", "are", "typically", "young", ",", "female", ",", "with", "C0022658#ent", "<e1>", "and", "either", "congenital", "or", "acquired", "C0853888#ent", "<e2>", ",", "and", "may", "present", "with", "all", "features", "of", "a", "lupus", "flare", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0853888", "name": "C0853888#ent", "pos": [15, 16]}}
{"token": ["In", "the", "high-dose", "exposure", "group", "activities", "of", "the", "enzymes", "glutathione", "peroxidase", "C1415326#ent", "<e1>", "and", "the", "C0030016#ent", "<e2>", "of", "glucose", "6-phosphate", "6-phosphogluconate", "were", "significantly", "elevated", "two-", "to", "fivefold", "at", "2", "-", "4", "d", "postexposure", "."], "h": {"id": "C1415326", "name": "C1415326#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "binding", "of", "C1332656#ent", "<e1>", "to", "self-Ags", "could", "increase", "the", "severity", "of", "an", "C0004364#ent", "<e2>", "enhancing", "the", "adaptive", "autoimmune", "response"], "h": {"id": "C1332656", "name": "C1332656#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "the", "molecular", "mechanisms", "in", "the", "C0042769#ent", "<e1>", "in", "this", "study", ",", "we", "investigated", "the", "role", "of", "C1175175#ent", "<e2>", "S", ")", "protein", "in", "the", "regulation", "of", "cyclooxygenase-2", "(", "COX-2", ")", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C1175175", "name": "C1175175#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "were", "attributed", "to", "a", "\"", "C0041912#ent", "<e1>", "\"", "osteomyelitis", "caused", "by", "pus", "beneath", "the", "C0151846#ent", "<e2>", "."], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0151846", "name": "C0151846#ent", "pos": [16, 17]}}
{"token": ["In", "accordance", "with", "reduced", "C0123707#ent", "<e1>", "and", "-4", "levels", ",", "C1704816#ent", "<e2>", "transgenic", "mice", "a", "20", "%", "decrease", "in", "weight", "prior", "to", "6", "weeks", "of", "age", "compared", "to", "wild", "type", "littermates", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704816", "name": "C1704816#ent", "pos": [10, 11]}}
{"token": ["Because", "C1510471#ent", "<e1>", "folate", "metabolism", "we", "determined", "the", "effects", "of", "nitrous", "oxide", "inactivation", "of", "C3713294#ent", "<e2>", "the", "compartmentation", "of", "folate", "metabolism", "rat", "pancreas", "."], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3713294", "name": "C3713294#ent", "pos": [14, 15]}}
{"token": ["Other", "immunosuppressed", "patients", "at", "risk", "for", "sepsis", "include", "those", "receiving", "myelosuppressive", "chemotherapy", "those", "with", "overwhelming", "malignancy", ",", "and", "those", "who", "suffer", "from", "C1623038#ent", "<e1>", ",", "diabetes", "mellitus", "and", "severe", "C0022806#ent", "<e2>", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0022806", "name": "C0022806#ent", "pos": [29, 30]}}
{"token": ["3", ")", "The", "congenital", "type", "a", "mild", "variant", "the", "C0013903#ent", "<e1>", "whereas", "the", "acquired", "type", "follows", "C0277565#ent", "<e2>"], "h": {"id": "C0013903", "name": "C0013903#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [16, 17]}}
{"token": ["Medicinal", "manipulations", "drugs", "to", "avoid", "(", "beta", "adrenergic", "blockers", "androgens", ",", "estrogens", ",", "glucocorticoids", ",", "ethyl", "alcohol", "C0012798#ent", "<e1>", ")", "and", "specific", "therapeutic", "agents", "activated", "charcoal", ",", "nicotinic", "acid", "C2347008#ent", "<e2>", ",", "L-carnitine", ")", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2347008", "name": "C2347008#ent", "pos": [29, 30]}}
{"token": ["However", ",", "these", "effects", "were", "lower", "with", "C0073992#ent", "<e1>", "C0015458#ent", "<e2>", "MDI", "than", "with", "the", "C0073992#ent", "<e1>", "CFC", "MDI", "at", "all", "dose", "levels", "."], "h": {"id": "C0015458", "name": "C0015458#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0073992", "name": "C0073992#ent", "pos": [7, 8]}}
{"token": ["8)", "C0037982#ent", "<e1>", "remains", "the", "treatment", "of", "choice", "for", "patients", "with", "C0018801#ent", "<e2>", "incapacitating", "dyspnea", "despite", "ACE", "inhibitor", "and", "diuretic", "therapy"], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}}
{"token": ["The", "murine", "Fra14A2", "locus", ",", "like", "the", "human", "C0919457#ent", "<e1>", ",", "was", "characterized", "by", "a", "high", "C0004135#ent", "<e2>", "content", "."], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [16, 17]}}
{"token": ["A", "total", "of", "64", "male", "albino", "rats", "were", "used", "in", "single-", "and", "multiple-dose", "experiments", "with", "AmpB", "and", "C0010592#ent", "<e1>", "in", "the", "absence", "or", "presence", "of", "systemic", "C0006846#ent", "<e2>"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006846", "name": "C0006846#ent", "pos": [26, 27]}}
{"token": ["Early", "in", "development", ",", "the", "pattern", "of", "C1415687#ent", "<e1>", "expression", "resembles", "that", "of", "C1414486#ent", "<e2>", "in", "limb", "and", "genital", "buds", "."], "h": {"id": "C1415687", "name": "C1415687#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414486", "name": "C1414486#ent", "pos": [13, 14]}}
{"token": ["The", "minor", "role", "of", "C0608437#ent", "<e1>", "in", "4'-hydroxy-PPC", "formation", "and", "the", "effect", "of", "C1332829#ent", "<e2>", "(S)-6-", "and", "(S)-7-hydroxy-PPC", "were", "confirmed", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332829", "name": "C1332829#ent", "pos": [13, 14]}}
{"token": ["Warfarin", "is", "metabolized", "by", "C0608437#ent", "<e1>", "its", "pharmacokinetic", "properties", "depend", "on", "structural", "polymorphisms", "of", "C1332829#ent", "<e2>"], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332829", "name": "C1332829#ent", "pos": [14, 15]}}
{"token": ["This", "study", "analyzed", "the", "frequency", "of", "C0608437#ent", "<e1>", "alleles", "and", "evaluated", "the", "impact", "of", "C1332829#ent", "<e2>", "diclofenac", "metabolism", "in", "a", "Spanish", "population"], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332829", "name": "C1332829#ent", "pos": [14, 15]}}
{"token": ["VZV", "virus-related", "peripheral", "neuropathies", "occur", "after", "C0019360#ent", "<e1>", "in", "adults", "and", "more", "rarely", "after", "C0008049#ent", "<e2>", "in", "childhood", "."], "h": {"id": "C0019360", "name": "C0019360#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0008049", "name": "C0008049#ent", "pos": [14, 15]}}
{"token": ["These", "results", "indicate", "that", "C1538719#ent", "<e1>", "may", "regulate", "C3536742#ent", "<e2>", "secretion", "but", "not", "the", "mitogenic", "effects", "chromaffin", "cells"], "h": {"id": "C1538719", "name": "C1538719#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "C2926735#ent", "<e1>", "of", "the", "initial", "transients", "in", "[Ca(2+)](i", ")", "following", "an", "C1705556#ent", "<e2>", "stimulus", "was", "significantly", "prolonged", "by", "exposure", "to", "30", "kV/m", "field", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [14, 15]}}
{"token": ["Using", "collections", "of", "varying", "C2926735#ent", "<e1>", ",", "the", "half-life", "of", "C1705556#ent", "<e2>", "in", "collected", "proximal", "tubular", "fluid", "found", "to", "be", "3.4", "min", ",", "indicating", "significant", "breakdown", "by", "soluble", "nucleotidases", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["ADP", ",", "AMP", ",", "GTP", ",", "UTP", ",", "ITP", ",", "C1268935#ent", "<e1>", ",", "or", "CTP", "did", "not", "substitute", "for", "C2744579#ent", "<e2>", "in", "energizing", "uptake", "."], "h": {"id": "C1268935", "name": "C1268935#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [19, 20]}}
{"token": ["Rat", "aortic", "smooth", "muscle", "to", "potassium", "chloride", "C0022245#ent", "<e1>", "in", "the", "presence", "of", "the", "alpha-adrenergic", "blocker", "C0733398#ent", "<e2>", "was", "investigated", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0733398", "name": "C0733398#ent", "pos": [16, 17]}}
{"token": ["In", "spite", "of", "rapid", "removal", "of", "the", "catheter", "at", "the", "time", "of", "clinical", "diagnosis", "phlebitis", "and", "adequate", "antibiotic", "treatment", "the", "Staphylococcus", "aureus", "C0243026#ent", "<e1>", "developed", "into", "C0014122#ent", "<e2>"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [26, 27]}}
{"token": ["Infection", "was", "initially", "localized", "to", "the", "pacemaker", "pocket", "seven", "patients", ",", "but", "C0243026#ent", "<e1>", "developed", "in", "one", "of", "them", "and", "C0014122#ent", "<e2>", "in", "another", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [20, 21]}}
{"token": ["Unfortunately", ",", "this", "practice", "has", "led", "to", "an", "intermediate", "resistance", "phenotype", "that", "is", "particularly", "difficult", "to", "treat", "in", "invasive", "staphylococcal", "diseases", "such", "as", "C0243026#ent", "<e1>", "and", "its", "metastatic", "complications", ",", "including", "C0014122#ent", "<e2>", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0014122", "name": "C0014122#ent", "pos": [31, 32]}}
{"token": ["Addition", "of", "the", "cAMP", "phosphodiesterase", "inhibitor", "3-isobutyl-1-methylxanthine", "(", "C0000096#ent", "<e1>", ")", "permitted", "detection", "of", "the", "novel", "C0001492#ent", "<e2>", "activity", "in", "lysates", "of", "an", "acaA/acgA", "double", "mutant", "."], "h": {"id": "C0000096", "name": "C0000096#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [16, 17]}}
{"token": ["Noncanonical", "WNT", "signals", "are", "transduced", "through", "Frizzled", "family", "receptors", "ROR2/RYK", "coreceptors", "to", "the", "Dishevelled-dependent", "(", "C0174045#ent", "<e1>", "c-jun", "NH(2)-terminal", "kinase", "or", "the", "Ca(2+)-dependent", "(", "NLK", "and", "C1417703#ent", "<e2>", "activated", "T", "cells", "signaling", "cascades"], "h": {"id": "C0174045", "name": "C0174045#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417703", "name": "C1417703#ent", "pos": [26, 27]}}
{"token": ["Significantly", "more", "patients", "who", "received", "C0039925#ent", "<e1>", "felt", "depressed", "postoperatively", ",", "and", "95", "%", "required", "parenteral", "C0002772#ent", "<e2>", "the", "recovery", "room"], "h": {"id": "C0039925", "name": "C0039925#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002772", "name": "C0002772#ent", "pos": [16, 17]}}
{"token": ["The", "mechanism", "of", "C0039445#ent", "<e1>", "cytotoxicity", "is", "related", "to", "down-regulation", "of", "C0812228#ent", "<e2>", "phosphorylation/activation", "and", "various", "target", "genes", "of", "C0812228#ent", "<e2>", "including", "nuclear", "factor", "kappa", "B", "XIAP", ",", "cIAP", "and", "cyclin", "D1"], "h": {"id": "C0039445", "name": "C0039445#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [11, 12]}}
{"token": ["On", "the", "other", "hand", ",", "impaired", "C1418596#ent", "<e1>", "expression", "in", "the", "C0406810#ent", "<e2>", "leads", "preferentially", "to", "PTA", "."], "h": {"id": "C1418596", "name": "C1418596#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0406810", "name": "C0406810#ent", "pos": [11, 12]}}
{"token": ["Lactoferrin", "has", "been", "reported", "to", "inhibit", "hepatitis", "C", "virus", "HCV", ")", "infection", "in", "cultured", "human", "C0669372#ent", "<e1>", "and", "HCV", "viremia", "in", "patients", "with", "C0524910#ent", "<e2>", "CHC", ")", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0524910", "name": "C0524910#ent", "pos": [23, 24]}}
{"token": ["A", "disrupted", "cell", "cycle", "progression", "of", "C0669372#ent", "<e1>", "was", "reported", "in", "C0524910#ent", "<e2>", "HCV", ")", "infection", ",", "which", "can", "contribute", "significantly", "in", "the", "associated", "pathogenesis", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524910", "name": "C0524910#ent", "pos": [11, 12]}}
{"token": ["The", "signal", "transduction", "pathway", "evaluated", "by", "inhibiting", "protein", "tyrosine", "kinase", "genistein", ",", "calmodulin", "with", "C0078437#ent", "<e1>", ",", "and", "calcineurin", "with", "C0010592#ent", "<e2>", "tacrolimus", "."], "h": {"id": "C0078437", "name": "C0078437#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [20, 21]}}
{"token": ["Higher", "hepatic", "GSH", "and", "lower", "TBARS", "concentrations", "were", "observed", "in", "rats", "C0342895#ent", "<e1>", "with", "the", "4", "%", "C0795864#ent", "<e2>", "diet", "compared", "with", "the", "rats", "C0342895#ent", "<e1>", "with", "the", "control", "diet"], "h": {"id": "C0795864", "name": "C0795864#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [11, 12]}}
{"token": ["The", "intensity", "of", "staining", "obtained", "with", "serial", "dilutions", "of", "the", "antibodies", "indicated", "that", "the", "cytoplasmic", "concentration", "of", "C0104940#ent", "<e1>", "tended", "to", "be", "higher", "than", "that", "of", "C0139030#ent", "<e2>"], "h": {"id": "C0104940", "name": "C0104940#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0139030", "name": "C0139030#ent", "pos": [26, 27]}}
{"token": ["Diagnosis", "of", "C3542501#ent", "<e1>", "very", "likely", "in", "a", "young", "adult", "acute", ",", "unilateral", "and", "C0030193#ent", "<e2>", "visual", "loss"], "h": {"id": "C3542501", "name": "C3542501#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [14, 15]}}
{"token": ["We", "describe", "the", "clinical", "characteristics", "and", "early", "natural", "history", "a", "form", "of", "C3542501#ent", "<e1>", "is", "frequently", "bilateral", "and", "often", "C0030193#ent", "<e2>", ",", "and", "is", "characterized", "by", "relapses", "and", "remissions", "."], "h": {"id": "C3542501", "name": "C3542501#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [19, 20]}}
{"token": ["Certain", "Cas", ",", "Crk", "or", "C3G", "suppressed", "C1426113#ent", "<e1>", "activation", "by", "C0124604#ent", "<e2>", "."], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [11, 12]}}
{"token": ["Thus", "the", "C0234230#ent", "<e1>", "which", "is", "often", "observed", "after", "the", "injection", "of", "C0001975#ent", "<e2>", ",", "is", "avoided", "."], "h": {"id": "C0234230", "name": "C0234230#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [12, 13]}}
{"token": ["Further", ",", "high", "affinity", "binding", "of", "C1336626#ent", "<e1>", "to", "C1705231#ent", "<e2>", "likely", "results", "from", "the", "trimeric", "structure", "C1336626#ent", "<e1>", "."], "h": {"id": "C1705231", "name": "C1705231#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1336626", "name": "C1336626#ent", "pos": [6, 7]}}
{"token": ["A", "36-year-old", "short-statured", "grande", "multipara", "(", "gravida", "10", "para", "8)", "with", "diabetes", "mellitus", "C0020480#ent", "<e1>", "was", "incidentally", "found", "to", "have", "C0265514#ent", "<e2>", "osteopoikilosis", "and", "dermatofibrosis", "lenticularis", "disseminata", "."], "h": {"id": "C0020480", "name": "C0020480#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0265514", "name": "C0265514#ent", "pos": [20, 21]}}
{"token": ["Inoculation", "of", "the", "Nocardia", "into", "the", "mouse", "peritoneal", "cavities", "caused", "marked", "C0521173#ent", "<e1>", "in", "the", "C0771711#ent", "<e2>", ",", "liver", "and", "regional", "lymph", "nodes", "but", "did", "not", "develop", "autophagic", "vacuoles", "RER", "regions", "of", "these", "organs", "."], "h": {"id": "C0521173", "name": "C0521173#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [15, 16]}}
{"token": ["Rothmund-Thomson", "syndrome", "a", "rare", "C1275089#ent", "<e1>", "by", "poikiloderma", "of", "the", "face", "and", "extremities", ",", "C0002170#ent", "<e2>", ",", "short", "stature", "and", "skeletal", "defects"], "h": {"id": "C1275089", "name": "C1275089#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [14, 15]}}
{"token": ["T", "cells", "primed", "to", "a", "glycopeptide", "with", "a", "simple", "glycan", "structure", "as", "C1705010#ent", "<e1>", "did", "not", "cross-respond", "significantly", "to", "other", "C0017953#ent", "<e2>", ",", "indicating", "a", "high", "degree", "of", "carbohydrate", "specificity", "T-cell", "recognition"], "h": {"id": "C1705010", "name": "C1705010#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017953", "name": "C0017953#ent", "pos": [20, 21]}}
{"token": ["Measurements", "of", "Doppler", "derived", "coronary", "flow", "reserve", "(", "CFR", ")", "and", "pressure", "derived", "fractional", "flow", "reserve", "FFR", ")", "for", "C0242231#ent", "<e1>", "assessment", "depend", "on", "the", "induction", "of", "C0020452#ent", "<e2>"], "h": {"id": "C0242231", "name": "C0242231#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0020452", "name": "C0020452#ent", "pos": [27, 28]}}
{"token": ["Our", "study", "showed", "that", "hepatic", "transplantation", "better", "than", "C0030817#ent", "<e1>", "in", "the", "treatment", "of", "C0019202#ent", "<e2>"], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "present", "evidence", "of", "active", "C0019693#ent", "<e1>", "i.e.", ",", "infected", "and", "not", "merely", "sensitized", "following", "C1366370#ent", "<e2>", "injections", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [17, 18]}}
{"token": ["A", "patient", "with", "C0019693#ent", "<e1>", "and", "hepatitis", "C", "virus", "HCV", ")", "co-infection", "developed", "an", "autoantibody", "to", "C1366370#ent", "<e2>", "8.7", "months", "of", "treatment", "with", "pegylated", "interferon-alpha", "ribavirin", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [16, 17]}}
{"token": ["Equilibrium", "denaturation", "recombinant", "porcine", "growth", "hormone", "C1565830#ent", "<e1>", ")", "derived", "from", "Escherichia", "coli", "the", "C0120447#ent", "<e2>", "GuHCl", ")", "was", "followed", "by", "ultraviolet", "absorption", "spectroscopy", "intrinsic", "fluorescence", "far-ultraviolet", "circular", "dichroism", ",", "and", "size-exclusion", "chromatography"], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0120447", "name": "C0120447#ent", "pos": [14, 15]}}
{"token": ["The", "authors", "evaluated", "carbamazepine", "(", "Tegretol", ")", ",", "a", "C0013227#ent", "<e1>", "of", "choice", "for", "treatment", "of", "C0014556#ent", "<e2>", "in", "a", "double-blind", "placebo-controlled", "trial", "patients", "with", "manic-depressive", "illness"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [16, 17]}}
{"token": ["Carbamazepine", ",", "a", "C0013227#ent", "<e1>", "useful", "in", "the", "treatment", "of", "trigeminal", "neuralgia", "C0014556#ent", "<e2>", "has", "recently", "been", "found", "to", "have", "positive", "psychotropic", "effects", "patients", "with", "manic", "and", "depressive", "illness"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "blocking", "C1412933#ent", "<e1>", "and", "cC1qR/CR", "by", "using", "specific", "antibodies", "abolished", "the", "chemotactic", "response", "C1412931#ent", "<e2>", "but", "had", "no", "effect", "on", "a", "different", "chemoattractant", "C5a", "."], "h": {"id": "C1412933", "name": "C1412933#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412931", "name": "C1412931#ent", "pos": [15, 16]}}
{"token": ["Inactivation", "of", "C0031671#ent", "<e1>", "EGFR", "kinase", ",", "and", "C0216471#ent", "<e2>", "specific", "inhibitors", "abolished", "PGF(2", "alpha)-induced", "trans-activation", "of", "EGFR", ",", "MAPK", "signaling", "and", "Ishikawa", "cell", "proliferation", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0216471", "name": "C0216471#ent", "pos": [8, 9]}}
{"token": ["Treatment", "of", "the", "solubilized", "receptors", "with", "C0030946#ent", "<e1>", "trypsin", "and", "C0030306#ent", "<e2>", "could", "partially", "or", "completely", "inactivate", "the", "viral", "receptors"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [10, 11]}}
{"token": ["However", ",", "C0030946#ent", "<e1>", "such", "as", "C0030306#ent", "<e2>", "and", "cathepsin", "G", "induce", "preferentially", "synthesis", "of", "PAF", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [6, 7]}}
{"token": ["Derepression", "of", "the", "Crt1", "C0206522#ent", "<e1>", "suppresses", "the", "lethality", "of", "mec1", "and", "C1706047#ent", "<e2>", "null", "alleles", "is", "essential", "for", "cell", "viability", "replicative", "stress", "."], "h": {"id": "C0206522", "name": "C0206522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706047", "name": "C1706047#ent", "pos": [12, 13]}}
{"token": ["Except", "at", "high", "doses", "pharmacological", "or", "humoral", "agents", ",", "including", "C0003211#ent", "<e1>", "alpha", "and", "C2936796#ent", "<e2>", "cyclic", "nucleotides", "theophylline", "or", "aminophylline", ",", "and", "histamine", ",", "generally", "had", "only", "small", "effects", "elastin", "production", "in", "this", "organ", "culture", "system"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2936796", "name": "C2936796#ent", "pos": [14, 15]}}
{"token": ["We", ",", "therefore", ",", "conclude", "that", "LPS", "downregulates", "C1418779#ent", "<e1>", "expression", "during", "C0243026#ent", "<e2>", "via", "an", "increase", "in", "TNF-alpha", "release", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}}
{"token": ["For", "the", "study", ",", "100", "healthy", "women", ",", "ASA", "physical", "status", "I", "II", ",", "scheduled", "for", "outpatient", "gynecologic", "laparoscopic", "procedures", "received", "4", "mg", "of", "intravenous", "ondansetron", "or", "C0022237#ent", "<e1>", "the", "treatment", "of", "C0520904#ent", "<e2>"], "h": {"id": "C0022237", "name": "C0022237#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0520904", "name": "C0520904#ent", "pos": [32, 33]}}
{"token": ["The", "authors", "concluded", "that", "murine", "C0041471#ent", "<e1>", "is", "an", "important", "C0035585#ent", "<e2>", "R.", "norvegicus", "is", "an", "important", "reservoir", "species", "of", "rodents", "found", "in", "markets", "of", "the", "BMA", "."], "h": {"id": "C0041471", "name": "C0041471#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035585", "name": "C0035585#ent", "pos": [10, 11]}}
{"token": ["C0041471#ent", "<e1>", "scrub", "typhus", "important", "human", "C0035585#ent", "<e2>", "Thailand", "."], "h": {"id": "C0041471", "name": "C0041471#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035585", "name": "C0035585#ent", "pos": [6, 7]}}
{"token": ["A", "term", "infant", "born", "to", "consanguineous", "parents", "presented", "at", "birth", "with", "hypoglycaemia", ",", "C0040034#ent", "<e1>", ",", "coagulopathy", "and", "C0022350#ent", "<e2>", "associated", "with", "polycythaemia", "due", "to", "delayed", "cord", "clamping"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022350", "name": "C0022350#ent", "pos": [18, 19]}}
{"token": ["The", "most", "unique", "feature", "of", "WSBV", "is", "the", "presence", "of", "an", "intact", "C1333079#ent", "<e1>", "a", "gene", "encoding", "an", "C1414248#ent", "<e2>", "animal", "cells", "has", "never", "been", "found", "in", "any", "viruses", "."], "h": {"id": "C1333079", "name": "C1333079#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414248", "name": "C1414248#ent", "pos": [18, 19]}}
{"token": ["In", "cis", "splicing", "a", "U5", "snRNP-specific", "protein", "component", "called", "C1424915#ent", "<e1>", "in", "yeast", "and", "C1417775#ent", "<e2>", "in", "man", "is", "a", "highly", "conserved", ",", "essential", "splicing", "factor", "in", "splice-site", "recognition", "and", "selection", "."], "h": {"id": "C1424915", "name": "C1424915#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417775", "name": "C1417775#ent", "pos": [14, 15]}}
{"token": ["With", "this", "new", "technique", "using", "sera", "from", "patients", "it", "should", "be", "possible", "to", "use", "the", "C1423108#ent", "<e1>", "technique", "of", "C0035690#ent", "<e2>"], "h": {"id": "C1423108", "name": "C1423108#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035690", "name": "C0035690#ent", "pos": [19, 20]}}
{"token": ["This", "study", "was", "designed", "to", "investigate", "the", "effect", "of", "C0017887#ent", "<e1>", "GTN", ")", "and", "calcium", "antagonists", "C3273436#ent", "<e2>", "contraction", "in", "the", "human", "IMA", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [16, 17]}}
{"token": ["Clinical", "investigations", "that", "the", "PCC", "is", "a", "safe", "and", "efficient", "preparation", "for", "the", "substitutive", "treatment", "C1705338#ent", "<e1>", "or", "FVII", "in", "patients", "suffering", "from", "the", "respective", "C0268487#ent", "<e2>", "."], "h": {"id": "C1705338", "name": "C1705338#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [25, 26]}}
{"token": ["Knock-down", "of", "endogenous", "SPIN90", "did", "not", "inhibit", "Src-induced", "cytoskeletal", "rearrangement", "whereas", "knock-down", "of", "C2703161#ent", "<e1>", "resulted", "in", "C1333200#ent", "<e2>", "disorganization", "and", "inhibition", "of", "remodeling", "."], "h": {"id": "C2703161", "name": "C2703161#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333200", "name": "C1333200#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "W-77", "enhances", "the", "antitumor", "activity", "C0085752#ent", "<e1>", "by", "inhibiting", "both", "C0796516#ent", "<e2>", "and", "P-glycoprotein", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0796516", "name": "C0796516#ent", "pos": [14, 15]}}
{"token": ["Each", "of", "the", "endocrine", "emergencies", "discussed", "here", "--", "adrenal", "crisis", "myxedema", "coma", "and", "C0040127#ent", "<e1>", "represents", "decompensation", "of", "a", "long-standing", "C0014130#ent", "<e2>", "is", "precipitated", "in", "most", "cases", "by", "some", "stressful", "event", "."], "h": {"id": "C0040127", "name": "C0040127#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [20, 21]}}
{"token": ["Previously", ",", "we", "discovered", "a", "novel", "pathway", "for", "C3538682#ent", "<e1>", "beta-catenin", "degradation", "through", "a", "ubiquitin", "E3", "ligase", "complex", "C1420045#ent", "<e2>", ",", "SIP", "(", "CacyBP", ")", ",", "Skp1", ",", "and", "Ebi", "."], "h": {"id": "C3538682", "name": "C3538682#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420045", "name": "C1420045#ent", "pos": [18, 19]}}
{"token": ["Intra-arterial", "tetrodotoxin", "C0005059#ent", "<e1>", "or", "intravenous", "naloxone", "1.0", "mg/kg", ")", "abolished", "the", "pyloric", "responses", "C3539946#ent", "<e2>", "P", "less", "than", "0.02", ")", "."], "h": {"id": "C0005059", "name": "C0005059#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [14, 15]}}
{"token": ["Resonance", "Raman", "spectra", "of", "the", "2,4-dinitrophenylhydrazine", "derivatives", "bovine", "plasma", "C0026454#ent", "<e1>", "amine", ":", "oxygen", "oxidoreductase", "deaminating", ")", "(", "copper-containing", ")", ",", "C3272401#ent", "<e2>", "have", "been", "measured", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3272401", "name": "C3272401#ent", "pos": [21, 22]}}
{"token": ["Light", "microscopic", "studies", "to", "visualize", "semicarbazide-sensitive", "and", "H2O2-generating", "C0026454#ent", "<e1>", "SSAOX", ",", "benzylamine", "oxidase", "BAOX", ";", "C3272401#ent", "<e2>", ")"], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3272401", "name": "C3272401#ent", "pos": [16, 17]}}
{"token": ["The", "5-HT", "regulation", "of", "the", "gene", "transcription", "factor", ",", "C1706383#ent", "<e1>", ",", "involves", "activation", "of", "C1708300#ent", "<e2>", "and", "ionotropic", "glutamate", "receptors"], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1708300", "name": "C1708300#ent", "pos": [15, 16]}}
{"token": ["C0333998#ent", "<e1>", "the", "gastrointestinal", "tract", "associated", "to", "endometriosis", "is", "an", "uncommon", "cause", "of", "C0009377#ent", "<e2>", "malabsortion", "."], "h": {"id": "C0333998", "name": "C0333998#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009377", "name": "C0009377#ent", "pos": [13, 14]}}
{"token": ["The", "purification", "of", "monoamine", "oxidase", "C1412100#ent", "<e1>", "normal", "human", "term", "C1571454#ent", "<e2>", "described", "."], "h": {"id": "C1412100", "name": "C1412100#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1571454", "name": "C1571454#ent", "pos": [10, 11]}}
{"token": ["C1412100#ent", "<e1>", "activity", "was", "associated", "with", "C1571454#ent", "<e2>", "and", "more", "than", "90", "%", "of", "the", "activity", "was", "localized", "in", "the", "maternal", "placenta", "."], "h": {"id": "C1412100", "name": "C1412100#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1571454", "name": "C1571454#ent", "pos": [6, 7]}}
{"token": ["Two", "children", "who", "died", "of", "this", "C0039082#ent", "<e1>", "had", "prominent", "Schwalbe's", "rings", "attached", "iris", "strands", "characteristic", "of", "C0265341#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0265341", "name": "C0265341#ent", "pos": [17, 18]}}
{"token": ["Neuronal", "pentraxins", "(", "C1836075#ent", "<e1>", ")", "define", "a", "family", "of", "proteins", "that", "are", "C1512488#ent", "<e2>", "to", "C-reactive", "and", "acute-phase", "proteins", "the", "immune", "system", "have", "been", "hypothesized", "to", "be", "involved", "in", "activity-dependent", "synaptic", "plasticity", "."], "h": {"id": "C1836075", "name": "C1836075#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "TIF1alpha", "is", "a", "C0031686#ent", "<e1>", "that", "undergoes", "ligand-dependent", "hyperphosphorylation", "as", "a", "consequence", "of", "C1709139#ent", "<e2>"], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1709139", "name": "C1709139#ent", "pos": [15, 16]}}
{"token": ["Among", "human", "WNT", "family", "WNT10A", "was", "most", "homologous", "to", "WNT10B", "(", "59.2", "%", "amino-acid", "identity", ")", ",", "and", "C1421516#ent", "<e1>", "was", "most", "homologous", "to", "C0812233#ent", "<e2>", "(", "47.4", "%", "amino-acid", "identity", ")", "."], "h": {"id": "C1421516", "name": "C1421516#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0812233", "name": "C0812233#ent", "pos": [24, 25]}}
{"token": ["In", "conclusion", ",", "C0166025#ent", "<e1>", "administration", "is", "an", "effective", "anti-osteoporotic", "treatment", "in", "C0029458#ent", "<e2>", "women", "with", "IBD", "in", "remission", "."], "h": {"id": "C0166025", "name": "C0166025#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [12, 13]}}
{"token": ["In", "the", "absence", "of", "wild-type", "C0299505#ent", "<e1>", ",", "as", "in", "C0694897#ent", "<e2>", "patients", "or", "in", "the", "majority", "of", "sporadic", "clear", "cell", "renal", "cell", "carcinomas", "HIF-responsive", "genes", "are", "inappropriately", "activated", "even", "under", "normoxia", "."], "h": {"id": "C0299505", "name": "C0299505#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0694897", "name": "C0694897#ent", "pos": [10, 11]}}
{"token": ["The", "induction", "of", "C1706383#ent", "<e1>", "was", "inhibited", "74", "%", "by", "the", "MEK1/2", "inhibitor", "C0755562#ent", "<e2>", "(", "p", "<", "0.001", ")", "but", "was", "not", "affected", "by", "MEK1", "or", "p38", "MAPK-specific", "inhibitors", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [13, 14]}}
{"token": ["Thirty-one", "percent", "of", "the", "diamond", "knife", "cases", "had", "C1719796#ent", "<e1>", "26", "%", "had", "no", "C0004106#ent", "<e2>", "."], "h": {"id": "C1719796", "name": "C1719796#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004106", "name": "C0004106#ent", "pos": [14, 15]}}
{"token": ["After", "correcting", "for", "the", "different", "molar", "equivalent", "of", "DMDZ", "available", "from", "each", "preparation", ",", "the", "DMDZ", "ratio", "averaged", "0.22", "for", "C0069749#ent", "<e1>", "vs.", "clorazepate", "and", "0.51", "for", "C0024002#ent", "<e2>", "vs.", "clorazepate", "."], "h": {"id": "C0069749", "name": "C0069749#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [27, 28]}}
{"token": ["C0085237#ent", "<e1>", "was", "alternatively", "with", "carbamazepine", "given", "to", "12", "patients", "with", "C0040997#ent", "<e2>", "a", "double-blind", "cross-over", "study", "2", "weeks", "."], "h": {"id": "C0085237", "name": "C0085237#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040997", "name": "C0040997#ent", "pos": [11, 12]}}
{"token": ["Knockdown", "of", "the", "C.", "elegans", "C1417377#ent", "<e1>", "ortholog", "CST-1", "shortens", "life", "span", "accelerates", "tissue", "aging", "while", "overexpression", "of", "C1704805#ent", "<e2>", "promotes", "life", "span", "delays", "aging", "."], "h": {"id": "C1417377", "name": "C1417377#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704805", "name": "C1704805#ent", "pos": [18, 19]}}
{"token": ["Once", "T", "cells", "activated", ",", "C1537422#ent", "<e1>", "was", "expressed", "stably", "in", "both", "C3540579#ent", "<e2>", "and", "Th2", "cells"], "h": {"id": "C1537422", "name": "C1537422#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [12, 13]}}
{"token": ["Electrical", "stimulation", "an", "overflow", "of", "tritium", "and", "C1705556#ent", "<e1>", "and", ",", "in", "the", "absence", "of", "C0032912#ent", "<e2>", "and", "suramin", ",", "contraction", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [15, 16]}}
{"token": ["At", "a", "high", "frequency", "(", "10", "Hz", ")", ",", "the", "first", "peak", "was", "mostly", "inhibited", "by", "alphabeta-m", "C1705556#ent", "<e1>", "and", "partially", "by", "C0032912#ent", "<e2>", "and", "BIBP", "3226", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [22, 23]}}
{"token": ["The", "evoked", "overflow", "of", "tritium", "was", "505", "%", "and", "the", "evoked", "overflow", "of", "C1705556#ent", "<e1>", "34", "%", "of", "that", "observed", "in", "the", "absence", "of", "C0032912#ent", "<e2>", ",", "suramin", "and", "rauwolscine", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [24, 25]}}
{"token": ["Mice", "were", "immunized", "with", "either", "an", "isometamidium-human", "serum", "albumin", "(", "C0393754#ent", "<e1>", ")", "conjugate", "or", "an", "isometamidium-porcine", "thyroglobulin", "conjugate", "(", "C0039512#ent", "<e2>", ")", "."], "h": {"id": "C0393754", "name": "C0393754#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [20, 21]}}
{"token": ["Another", "limitation", "of", "the", "current", "C2985165#ent", "<e1>", "is", "the", "insufficient", "amount", "of", "significance", "addressed", "to", "C0041323#ent", "<e2>", "and", "the", "apparent", "lack", "of", "concerted", "control", "efforts", "against", "HIV", "infection", "AIDS", ",", "and", "C0041323#ent", "<e2>", "."], "h": {"id": "C2985165", "name": "C2985165#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [15, 16]}}
{"token": ["He", "also", "had", "squamous", "cell", "carcinoma", "the", "soft", "palate", "C0022661#ent", "<e1>", "hypertension", ",", "type-4", "renal", "tubular", "acidosis", "a", "hyperplastic", "thyroid", "adenoma", "and", "C0376185#ent", "<e2>"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0376185", "name": "C0376185#ent", "pos": [22, 23]}}
{"token": ["Western", "blot", "analysis", "potential", "signaling", "events", "associated", "with", "CH", ",", "including", "up-regulation", "of", "endothelial", "differentiation", "C0073209#ent", "<e1>", "activation", "of", "C0082529#ent", "<e2>", "p38", ",", "and", "the", "transcription", "factor", "activating", "transcription", "factor-2", "which", "were", "reduced", "after", "administration", "of", "DOX", "."], "h": {"id": "C0073209", "name": "C0073209#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [19, 20]}}
{"token": ["Recombinant", "C1704467#ent", "<e1>", "fails", "to", "prevent", "thiol", "modification", "of", "C1335833#ent", "<e2>", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335833", "name": "C1335833#ent", "pos": [9, 10]}}
{"token": ["Indeed", ",", "this", "biological", "activity", "to", "be", "the", "result", "of", "the", "co-expression", "of", "at", "least", "two", "isoforms", "of", "nucleoside", "carriers", "CNT1", "and", "C1420170#ent", "<e1>", "(", "also", "called", "C3810553#ent", "<e2>", ")", "."], "h": {"id": "C1420170", "name": "C1420170#ent", "pos": [22, 23]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3810553", "name": "C3810553#ent", "pos": [27, 28]}}
{"token": ["Ypk1", "is", "a", "C1334043#ent", "<e1>", "of", "the", "mammalian", "serum-", "and", "C0661256#ent", "<e2>", "SGK", ",", "which", "can", "substitute", "for", "Ypk1", "function", "in", "yeast", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0661256", "name": "C0661256#ent", "pos": [10, 11]}}
{"token": ["We", "have", "cloned", "a", "420", "bp", "cDNA", "from", "a", "human", "fetal", "brain", "cDNA", "library", "in", "lambda", "encoding", "the", "human", "C1334043#ent", "<e1>", "of", "a", "C0661256#ent", "<e2>", "DIP", ")", "isolated", "from", "porcine", "brain", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0661256", "name": "C0661256#ent", "pos": [23, 24]}}
{"token": ["CXCL9", ",", "CXCL10", ",", "and", "C1332816#ent", "<e1>", "production", "by", "keratinocytes", "depends", "on", "nuclear", "factor-kappaB", "C2986464#ent", "<e2>", ")", "and", "signal", "transducer", "activator", "of", "transcription", "and", "that", "of", "C1332816#ent", "<e1>", "depends", "on", "interferon", "(IFN)-regulatory", "factor", "(IRF)-1", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332816", "name": "C1332816#ent", "pos": [5, 6]}}
{"token": ["Purified", "MMP-II", "stimulated", "DCs", "from", "healthy", "individuals", "to", "produce", "interleukin-12", "p70", "and", "up-regulated", "the", "surface", "expression", "of", "major", "C0024518#ent", "<e1>", "II", ",", "CD86", ",", "and", "C2827381#ent", "<e2>"], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2827381", "name": "C2827381#ent", "pos": [25, 26]}}
{"token": ["We", "identified", "93", "C1417679#ent", "<e1>", "whose", "down-regulation", "led", "to", "penetrant", "C0015644#ent", "<e2>", "defects", "or", "motoneuron", "commissure", "outgrowth", "defects", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015644", "name": "C0015644#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "C0004259#ent", "<e1>", "methylnitrate", "(", "2", "mg/kg", ")", "did", "not", "block", "C0031849#ent", "<e2>", "hypothermia", "in", "either", "sex", ",", "but", "markedly", "decreased", "physostigmine's", "protective", "effect", "females", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031849", "name": "C0031849#ent", "pos": [13, 14]}}
{"token": ["Freshly", "isolated", "intact", "ox", "C1826396#ent", "<e1>", "have", "been", "incubated", "with", "copper(II)-o-phenanthroline", "complex", "to", "induce", "C0599532#ent", "<e2>", "cross-linking", "between", "the", "two", "largest", "(", "apparent", "Mr", "205", "000", "and", "158", "000", ")", "polypeptide", "components"], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [14, 15]}}
{"token": ["This", "region", "also", "contains", "a", "C0079429#ent", "<e1>", "specifying", "a", "C0023414#ent", "<e2>", "precursor", "and", "a", "remnant", "of", "a", "tau", "element"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023414", "name": "C0023414#ent", "pos": [9, 10]}}
{"token": ["In", "the", "present", "work", ",", "the", "C0079429#ent", "<e1>", "encoding", "human", "mitochondrial", "C0023414#ent", "<e2>", "the", "same", "N-terminus", "as", "that", "processed", "in", "the", "mitochondria", "of", "insect", "cell", "cloned", "and", "expressed", "in", "Escherichia", "coli"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023414", "name": "C0023414#ent", "pos": [11, 12]}}
{"token": ["Conversely", ",", "consistent", "with", "role", "in", "facilitated", "processing", ",", "NMDA", ",", "cyclooxygenase", "2", "and", "C1538973#ent", "<e1>", "inhibitors", "act", "to", "diminish", "only", "C0020429#ent", "<e2>", "."], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [21, 22]}}
{"token": ["C1415167#ent", "<e1>", "EC", "3.5.99.6", ")", "from", "Escherichia", "coli", "an", "C0014442#ent", "<e2>", "the", "K-type", ",", "activated", "by", "N-acetylglucosamine", "6-phosphate"], "h": {"id": "C1415167", "name": "C1415167#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["So", "it", "is", "not", "necessary", "to", "check", "C1415167#ent", "<e1>", "activity", "as", "a", "part", "of", "routine", "C0014442#ent", "<e2>", "chemistry", "."], "h": {"id": "C1415167", "name": "C1415167#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["Like", "C1419719#ent", "<e1>", "and", "L34", ",", "the", "transcription", "of", "C0029282#ent", "<e2>", "arginine", "decarboxylase", "especially", "sensitive", "to", "polyamines", "."], "h": {"id": "C1419719", "name": "C1419719#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [9, 10]}}
{"token": ["Although", "C1335654#ent", "<e1>", "stimulates", "transcription", ",", "C0919449#ent", "<e2>", "functions", "as", "a", "repressor", "of", "some", "C1335654#ent", "<e1>", "target", "genes", "."], "h": {"id": "C0919449", "name": "C0919449#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [1, 2]}}
{"token": ["The", "reverse-phase", ",", "thin-layer", "chromatography-isolated", "neutral", "fraction", "glycolipid", "component", ",", "designated", "C1826368#ent", "<e1>", ",", "was", "efficient", "in", "the", "serological", "discrimination", "C0013502#ent", "<e2>", "to", "high-titred", "sera", "."], "h": {"id": "C1826368", "name": "C1826368#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [20, 21]}}
{"token": ["Several", "animal", "studies", "demonstrated", "that", "pain", "is", "modulated", "by", "spinal", "mechanisms", "C3540754#ent", "<e1>", "and", "that", "acetylsalicylic", "acid", "C0007804#ent", "<e2>", ")", "administered", "intrathecally", "has", "an", "analgesic", "effect"], "h": {"id": "C3540754", "name": "C3540754#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [17, 18]}}
{"token": ["C0034735#ent", "<e1>", "Raynaud's", "disease", ",", "an", "accessual", "C0042373#ent", "<e2>", "by", "an", "important", "constriction", "of", "distal", "arterioles", "has", "still", "no", "specific", "pharmacological", "therapy"], "h": {"id": "C0034735", "name": "C0034735#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [7, 8]}}
{"token": ["C0040979#ent", "<e1>", "and", "chlorpromazine", ",", "C3494348#ent", "<e2>", "of", "calmodulin", "action", "potentiate", "slow", "inward", "current", "in", "molluscan", "neurons", "identically", "to", "the", "action", "of", "cAMP", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [5, 6]}}
{"token": ["It", "is", "inhibited", "by", "substances", "interfering", "calcium-calmodulin", "function", "C0040979#ent", "<e1>", "and", "W7", ")", ",", "but", "not", "by", "C3494348#ent", "<e2>", "of", "physiologic", "calcium", "channels", "nimodipine", ",", "verapamil", ",", "and", "D", "888", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [17, 18]}}
{"token": ["The", "Ku70/80", "heterodimer", "is", "the", "regulatory", "subunit", "the", "C0212694#ent", "<e1>", "DNA-PK", ")", "and", "its", "C0812382#ent", "<e2>", "DNA", "double-strand", "breaks", "repair"], "h": {"id": "C0212694", "name": "C0212694#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "C1137427#ent", "<e1>", "an", "important", "advance", "in", "the", "treatment", "of", "C0002986#ent", "<e2>", "and", "agalsidase", "beta", "therapy", "should", "be", "strongly", "considered", "in", "patients", "with", "C0002986#ent", "<e2>", "are", "suitable", "candidates", "."], "h": {"id": "C1137427", "name": "C1137427#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0002986", "name": "C0002986#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "treatment", "with", "C1137427#ent", "<e1>", "safe", "and", "effective", "in", "Japanese", "patients", "with", "C0002986#ent", "<e2>"], "h": {"id": "C1137427", "name": "C1137427#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0002986", "name": "C0002986#ent", "pos": [15, 16]}}
{"token": ["Although", "it", "shares", "a", "common", "active", "site", "architecture", "with", "bacterial", "C0027803#ent", "<e1>", ",", "the", "T.cruzi", "enzyme", "behaves", "as", "a", "highly", "efficient", "C0163611#ent", "<e2>", "."], "h": {"id": "C0027803", "name": "C0027803#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0163611", "name": "C0163611#ent", "pos": [21, 22]}}
{"token": ["Human", "C0024748#ent", "<e1>", "is", "a", "lysosomal", "storage", "disorder", "by", "mental", "retardation", "C0086795#ent", "<e2>", "and", "hepatosplenomegaly", "."], "h": {"id": "C0024748", "name": "C0024748#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0086795", "name": "C0086795#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "to", "study", "the", "physiological", "role", "of", "C1421338#ent", "<e1>", "enzymes", ",", "transgenic", "mice", "the", "human", "C3537396#ent", "<e2>", "recently", "obtained", "."], "h": {"id": "C1421338", "name": "C1421338#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537396", "name": "C3537396#ent", "pos": [16, 17]}}
{"token": ["In", "LNCaP", "cells", ",", "IL-1alpha", "and", "EGF", "also", "regulate", "C1421338#ent", "<e1>", "expression", "in", "an", "isoform-specific", "manner", "IL-1alpha", "induced", "C3537396#ent", "<e2>", "and", "reduced", "UGT2B17", ",", "while", "having", "no", "effects", "on", "UGT2B11", "mRNA", "levels", "."], "h": {"id": "C1421338", "name": "C1421338#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537396", "name": "C3537396#ent", "pos": [18, 19]}}
{"token": ["We", "recently", "identified", "C3274598#ent", "<e1>", "as", "a", "variant", "C1412097#ent", "<e2>", "fusion", "gene", "in", "6", "%", "of", "T-ALL", "patients", "."], "h": {"id": "C3274598", "name": "C3274598#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [8, 9]}}
{"token": ["In", "Y2", "(", "Y2-/-", ")", "and", "Y5", "(", "Y5-/-", ")", "receptor", "knockouts", ",", "C1705518#ent", "<e1>", "partially", "inhibited", "0", "C1417500#ent", "<e2>", "+", "-induced", "epileptiform", "activity", "in", "hippocampal", "slices", "."], "h": {"id": "C1705518", "name": "C1705518#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [18, 19]}}
{"token": ["C0442893#ent", "<e1>", "lead", "to", "cholangitis", "in", "varying", "proportion", "to", "C0019159#ent", "<e2>", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [9, 10]}}
{"token": ["In", "the", "C1956391#ent", "<e1>", "group", ",", "the", "levels", "of", "IgG", ",", "IgM", "and", "C4283853#ent", "<e2>", "were", "significantly", "higher", "than", "in", "the", "idiopathic", "group"], "h": {"id": "C1956391", "name": "C1956391#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "C1412523#ent", "<e1>", "increased", "the", "V(max", ")", "of", "C3889280#ent", "<e2>", "and", "enhanced", "its", "response", "to", "Ca(2+)", "stimulation", "."], "h": {"id": "C1412523", "name": "C1412523#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889280", "name": "C3889280#ent", "pos": [9, 10]}}
{"token": ["C0002963#ent", "<e1>", "a", "well", "documented", "cause", "of", "variant", "C0002962#ent", "<e2>"], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [8, 9]}}
{"token": ["Report", "of", "one", "case", "of", "C0002963#ent", "<e1>", "variant", "of", "C0002962#ent", "<e2>", "a", "typical", "clinical", "and", "electrocardiographic", "picture", "a", "man", "aged", "87", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [9, 10]}}
{"token": ["C0022642#ent", "<e1>", ",", "a", "cycloheptathiophene", "derivative", ",", "and", "C0546858#ent", "<e2>", ",", "given", "to", "the", "recipient", "in", "maximal", "clinical", "doses", "3", "days", ",", "inhibited", "the", "immediate", "reaction"], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0546858", "name": "C0546858#ent", "pos": [8, 9]}}
{"token": ["Fifty-seven", "children", ",", "twenty-nine", "in", "the", "C0022642#ent", "<e1>", "group", "and", "twenty-eight", "in", "the", "C0546858#ent", "<e2>", "group", "took", "part", "."], "h": {"id": "C0022642", "name": "C0022642#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0546858", "name": "C0546858#ent", "pos": [13, 14]}}
{"token": ["15", "patients", "with", "rheumatoid", "arthritis", "C0029408#ent", "<e1>", "received", "a", "single", "dose", "20", "mg", ")", "C0031990#ent", "<e2>", "(", "Felden", ")", "as", "suppository", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [14, 15]}}
{"token": ["Imidazole", "salicylate", "active", "in", "controlling", "a", "number", "of", "the", "pain", "symptoms", "by", "C0029408#ent", "<e1>", ",", "although", "its", "efficacy", "was", "inferior", "to", "that", "of", "C0031990#ent", "<e2>", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [23, 24]}}
{"token": ["Eighty", "patients", "with", "C0029408#ent", "<e1>", "were", "randomly", "assigned", "to", "either", "C0031990#ent", "<e2>", "(", "20", "mg", "daily", ")", "or", "diclofenac", "(", "75", "-", "150", "mg", "daily", ")", "in", "a", "12-week", "double-blind", ",", "parallel", "groups", "study"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "describe", "a", "novel", "C0678929#ent", "<e1>", "we", "call", "Uty", "(", "C1421414#ent", "<e2>", "tetratricopeptide", "repeat", "gene", "the", "Y", "chromosome", "."], "h": {"id": "C0678929", "name": "C0678929#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421414", "name": "C1421414#ent", "pos": [11, 12]}}
{"token": ["Recent", "controlled", "studies", "confirmed", "that", "hepatitis", "C", "virus", "HCV", ")", "is", "the", "main", "correlate", "of", "C0023895#ent", "<e1>", "patients", "with", "C0206139#ent", "<e2>", "LP", ")", ",", "mainly", "in", "southern", "Europe", "Japan", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0206139", "name": "C0206139#ent", "pos": [19, 20]}}
{"token": ["C0023895#ent", "<e1>", "now", "a", "well", "recognized", "association", "with", "C0206139#ent", "<e2>"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0206139", "name": "C0206139#ent", "pos": [8, 9]}}
{"token": ["C0023895#ent", "<e1>", "especially", "chronic", "hepatitis", "have", "been", "found", "to", "be", "associated", "with", "C0206139#ent", "<e2>"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0206139", "name": "C0206139#ent", "pos": [12, 13]}}
{"token": ["Twenty-two", "patients", "with", "C0040262#ent", "<e1>", "pityriasis", "versicolor", "were", "treated", "with", "single", "400", "mg", "dose", "of", "C0022625#ent", "<e2>", "and", "evaluated", "one", "month", "later", "."], "h": {"id": "C0040262", "name": "C0040262#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [15, 16]}}
{"token": ["The", "diagnosis", "of", "C0524620#ent", "<e1>", "reserved", "for", "C0362046#ent", "<e2>", "patients", "who", "share", "the", "risk", "of", "becoming", "diabetic", "or", "developing", "cardiovascular", "or", "chronic", "kidney", "disease"], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [7, 8]}}
{"token": ["In", "the", "present", "case", ",", "the", "C0221169#ent", "<e1>", "disappeared", "when", "very", "large", "doses", "of", "C0038317#ent", "<e2>", "were", "given", "."], "h": {"id": "C0221169", "name": "C0221169#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [14, 15]}}
{"token": ["Sickle", "cell", "disease", "the", "family", "of", "clinically", "significant", "C0019045#ent", "<e1>", "have", "in", "common", "the", "inheritance", "of", "the", "C0019034#ent", "<e2>"], "h": {"id": "C0019045", "name": "C0019045#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0019034", "name": "C0019034#ent", "pos": [17, 18]}}
{"token": ["Renal", "medullary", "carcinoma", "RMC", ")", "is", "an", "aggressive", "neoplasm", "almost", "exclusively", "in", "adolescents", "and", "young", "adults", "sickle", "cell", "SC", ")", "C0019045#ent", "<e1>", ",", "usually", "sickle", "cell", "trait", "SCT", ")", "or", "C0019034#ent", "<e2>"], "h": {"id": "C0019045", "name": "C0019045#ent", "pos": [20, 21]}, "relation": "nichd_parent_of", "t": {"id": "C0019034", "name": "C0019034#ent", "pos": [30, 31]}}
{"token": ["Extensive", "conformational", "analysis", "theoretical", "calculations", "low-temperature", "experiments", ")", "supported", "by", "the", "NMR", "studies", "of", "structurally", "diverse", "C0054741#ent", "<e1>", "amides", "of", "C0020402#ent", "<e2>", "and", "aminophosphonates", "proved", "that", "a", "simplified", "model", "can", "be", "successfully", "used", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [20, 21]}}
{"token": ["The", "most", "common", "causes", "of", "C0020550#ent", "<e1>", "are", "Graves'", "disease", "toxic", "nodular", "goiter", "and", "C0342142#ent", "<e2>"], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0342142", "name": "C0342142#ent", "pos": [14, 15]}}
{"token": ["Exposure", "of", "L1210", "or", "D-R", "cells", "to", "AOAP", "greatly", "decreased", "C1422630#ent", "<e1>", "activity", "in", "undialysed", "cell", "extracts", "but", "did", "not", "decrease", "C3539530#ent", "<e2>", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539530", "name": "C3539530#ent", "pos": [21, 22]}}
{"token": ["Following", "ischemia", ",", "putrescine", "content", "increases", "as", "a", "result", "of", "posttraumatic", "activation", "C1422630#ent", "<e1>", "and", "inhibition", "of", "C3539530#ent", "<e2>", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539530", "name": "C3539530#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "lomefloxacin", "along", "with", "C0271408#ent", "<e1>", "showed", "significantly", "low", "C0162830#ent", "<e2>", "."], "h": {"id": "C0271408", "name": "C0271408#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162830", "name": "C0162830#ent", "pos": [10, 11]}}
{"token": ["If", "C2347999#ent", "<e1>", "is", "metabolized", "to", "4", ",", "C2347999#ent", "<e1>", "in", "rat", "liver", ",", "then", "either", "this", "substance", "is", "not", "converted", "to", "reactive", "esters", "they", "are", "rapidly", "detoxified", "."], "h": {"id": "C2347999", "name": "C2347999#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2347999", "name": "C2347999#ent", "pos": [1, 2]}}
{"token": ["We", "report", "our", "experience", "with", "the", "oral", "imidazole", "agent", "C0022625#ent", "<e1>", "in", "the", "management", "of", "8", "patients", "with", "significant", "C0006849#ent", "<e2>", "judged", "by", "elevated", "urinary", "candidal", "counts", "(", "greater", "than", "15,000/ml", ".", ")", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [19, 20]}}
{"token": ["Oral", "treatment", "C0022625#ent", "<e1>", "prevented", "and", "cured", "artificial", "crop", "C0006849#ent", "<e2>", "of", "the", "turkey", ",", "vaginal", "candidosis", "the", "rat", "and", "skin", "candidosis", "the", "guinea-pig", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [9, 10]}}
{"token": ["An", "mAb", "raised", "to", "highly", "purified", ",", "immunoisolated", "MIICs", "from", "human", "B", "lymphoblastoid", "cells", "C1705784#ent", "<e1>", ",", "a", "member", "of", "the", "C1540084#ent", "<e2>", "family", "of", "integral", "membrane", "proteins"], "h": {"id": "C1705784", "name": "C1705784#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1540084", "name": "C1540084#ent", "pos": [21, 22]}}
{"token": ["Mice", "deficient", "in", "C1332672#ent", "<e1>", "are", "highly", "susceptible", "to", "experimental", "autoimmune", "encephalomyelitis", "suggesting", "that", "the", "dysregulation", "of", "signalling", "pathways", "modulated", "by", "C1332672#ent", "<e1>", "may", "also", "contribute", "to", "human", "C0004364#ent", "<e1>", "as", "multiple", "sclerosis"], "h": {"id": "C1332672", "name": "C1332672#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [28, 29]}}
{"token": ["Interestingly", ",", "we", "found", "that", "sumoylation", "of", "C1442760#ent", "<e1>", "blocks", "interaction", "with", "C1337090#ent", "<e2>", "and", "prevents", "C1442760#ent", "<e1>", "acetylation", "in", "vitro"], "h": {"id": "C1337090", "name": "C1337090#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1442760", "name": "C1442760#ent", "pos": [7, 8]}}
{"token": ["The", "agents", "approved", "for", "C0149931#ent", "<e1>", "prophylaxis", "are", "the", "anti-epileptic", "agents", "C0886883#ent", "<e2>", "and", "topiramate", ",", "and", "the", "beta-adrenergic", "antagonists", "propranolol", "and", "timolol", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [4, 5]}, "relation": "may_be_prevented_by", "t": {"id": "C0886883", "name": "C0886883#ent", "pos": [11, 12]}}
{"token": ["Phloretin", "and", "C1161334#ent", "<e1>", "inhibitors", "of", "the", "monocarboxylate", "transporter", "C0724624#ent", "<e2>", ")", ",", "significantly", "reduced", "ECG", "uptake", "."], "h": {"id": "C1161334", "name": "C1161334#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [9, 10]}}
{"token": ["In", "both", "lines", ",", "the", "human", "C1415692#ent", "<e1>", "transgene", "was", "expressed", "C0669365#ent", "<e2>", "in", "alveolar", "macrophages", "a", "high", "level", ",", "whereas", "the", "endogenous", "mouse", "C1415692#ent", "<e1>", "was", "synthesized", "in", "airway", "epithelial", "cells"], "h": {"id": "C1415692", "name": "C1415692#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["Further", ",", "cultured", "rat", "MCs", "overexpressing", "C1453853#ent", "<e1>", "ILK", "diminished", "C1706331#ent", "<e2>", "assembly", "and", "collagen", "matrix", "remodeling", "as", "compared", "with", "control", "transfectants", "."], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [10, 11]}}
{"token": ["Itraconazole", "is", "a", "broad-spectrum", "oral", "triazole", "whose", "greatest", "advantages", "over", "the", "C0020924#ent", "<e1>", "are", "in", "its", "activity", "against", "C0004030#ent", "<e2>", "and", "cryptococcosis", ",", "though", "it", "is", "also", "efficacious", "against", "the", "endemic", "deep", "mycoses"], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [18, 19]}}
{"token": ["These", "lines", "of", "evidence", "suggest", "that", "during", "development", "as", "well", "as", "C0014553#ent", "<e1>", "frequent", "expressions", "of", "IEGs", "and", "syntheses", "of", "C0087140#ent", "<e2>", "and", "Zif", "proteins", "might", "facilitate", "synaptic", "conductivity", "in", "epileptogenesis", "."], "h": {"id": "C0014553", "name": "C0014553#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [20, 21]}}
{"token": ["The", "biological", "basis", "be", "that", "leukocyte", "adherence", "to", "vascular", "endothelium", "by", "adhesion", "molecules", "C4284022#ent", "<e1>", ")", "facilitates", "vaso-occlusion", ",", "the", "basic", "pathological", "process", "in", "C0342788#ent", "<e2>", "."], "h": {"id": "C4284022", "name": "C4284022#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0342788", "name": "C0342788#ent", "pos": [24, 25]}}
{"token": ["When", "a", "global", "moving", "is", "superimposed", "on", "high-contrast", "stationary", "or", "slowly", "moving", "stimuli", "the", "latter", "occasionally", "C0029436#ent", "<e1>", "for", "periods", "of", "several", "seconds", "(", "motion-induced", "blindness", ",", "C3539751#ent", "<e2>", ")", "."], "h": {"id": "C0029436", "name": "C0029436#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539751", "name": "C3539751#ent", "pos": [27, 28]}}
{"token": ["Abnormal", "calcium", "channels", "genes", "responsible", "for", "hypokaleamic", "periodic", "paralysis", "C1413064#ent", "<e1>", ")", "as", "well", "as", "some", "forms", "of", "C0004134#ent", "<e2>", ",", "cerebellar", "degeneration", "migraine", "(", "CACNA1A", ")", "."], "h": {"id": "C1413064", "name": "C1413064#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [18, 19]}}
{"token": ["The", "maximum", "tolerated", "dose", "was", "500", "ng/kg", ",", "and", "the", "principal", "toxicities", "flulike", "symptoms", "C0002594#ent", "<e1>", "or", "bilirubin", "elevations", "neutropenia", ",", "C0002878#ent", "<e2>", "and", "depression", "."], "h": {"id": "C0002594", "name": "C0002594#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [21, 22]}}
{"token": ["Although", "the", "C0002594#ent", "<e1>", "decreased", ",", "jaundice", "persisted", "and", "C0002878#ent", "<e2>", "."], "h": {"id": "C0002594", "name": "C0002594#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [9, 10]}}
{"token": ["FISH", "analysis", "a", "patient", "with", "myelodysplastic", "syndrome", "by", "myeloid", "hypoplasia", "monocytosis", "reveals", "C4022022#ent", "<e1>", "of", "the", "HePTP", "gene", "one", "C0002085#ent", "<e2>", "with", "elevated", "protein", "expression", "neoplastic", "myelomonocytic", "cells", "."], "h": {"id": "C4022022", "name": "C4022022#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [19, 20]}}
{"token": ["Based", "on", "the", "findings", "of", "this", "study", ",", "C0342527#ent", "<e1>", "not", "be", "considered", "as", "a", "risk", "factor", "C0031090#ent", "<e2>"], "h": {"id": "C0342527", "name": "C0342527#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [17, 18]}}
{"token": ["In", "order", "to", "find", "ways", "to", "increase", "the", "usually", "very", "low", "bioavailability", "of", "C0032911#ent", "<e1>", ",", "the", "effect", "of", "C3850056#ent", "<e2>", "the", "metabolism", "of", "C0032911#ent", "<e1>", "was", "investigated", "in", "rats", "."], "h": {"id": "C0032911", "name": "C0032911#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3850056", "name": "C3850056#ent", "pos": [19, 20]}}
{"token": ["HGF", "treatment", "caused", "activation", "of", "the", "activator", "protein-1", "C1413322#ent", "<e1>", "and", "cAMP", "response", "element-binding", "protein", "transcription", "factors", "and", "COX-2", "induction", "was", "blocked", "by", "C3536807#ent", "<e2>", "D.", "The", "half-life", "of", "COX-2", "mRNA", "was", "also", "increased", "by", "HGF", "."], "h": {"id": "C1413322", "name": "C1413322#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536807", "name": "C3536807#ent", "pos": [23, 24]}}
{"token": ["Fermentation", "studies", "of", "batch-mode", "cultivation", "in", "4-L", "fermenters", "were", "carried", "out", "to", "obtain", "an", "active", "recombinant", "DNA-derived", "tissue", "plasminogen", "activator", "C0032143#ent", "<e1>", ")", "deletion", "mutant", ",", "C1121007#ent", "<e2>", ",", "secreted", "and", "correctly", "folded", "from", "Escherichia", "coli"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1121007", "name": "C1121007#ent", "pos": [26, 27]}}
{"token": ["Fermentation", "studies", "of", "batch-mode", "cultivation", "in", "4-L", "fermenters", "were", "carried", "out", "to", "obtain", "an", "active", "recombinant", "C0032143#ent", "<e1>", "t-PA", ")", "deletion", "mutant", ",", "C1121007#ent", "<e2>", ",", "secreted", "and", "correctly", "folded", "from", "Escherichia", "coli"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1121007", "name": "C1121007#ent", "pos": [23, 24]}}
{"token": ["In", "the", "following", "study", ",", "we", "evaluated", "the", "pharmacokinetic", "characteristics", "of", "high-dose", "C0010583#ent", "<e1>", "in", "three", "patients", "undergoing", "autologous", "stem", "cell", "transplantation", "C0026769#ent", "<e2>"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [22, 23]}}
{"token": ["These", "data", "suggest", "that", "C0731141#ent", "<e1>", "patch", "treatment", "induced", "NO", "release", ",", "and", "that", "C1420295#ent", "<e2>", "differences", "in", "transdermal", "GTN-derived", "NO", "exist", "."], "h": {"id": "C0731141", "name": "C0731141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [14, 15]}}
{"token": ["Treatment", "of", "C0006848#ent", "<e1>", "and", "cutaneous", "Candida", "albicans", "with", "C0162713#ent", "<e2>", "light", ",", "termed", "photodynamic", "therapy", "PDT", ")", ",", "offers", "an", "alternative", "to", "conventional", "treatments", "."], "h": {"id": "C0006848", "name": "C0006848#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162713", "name": "C0162713#ent", "pos": [9, 10]}}
{"token": ["C0595993#ent", "<e1>", "been", "speculated", "to", "be", "a", "C0042769#ent", "<e2>", "its", "pathogen", "is", "unknown", "."], "h": {"id": "C0595993", "name": "C0595993#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["Forty-eight", "hours", "after", "I/R", ",", "TK-MSCs", "inhibited", "interstitial", "neutrophil", "C1413347#ent", "<e1>", "infiltration", "and", "decreased", "myeloperoxidase", "activity", "superoxide", "formation", "C1456378#ent", "<e2>", "and", "expression", "of", "tumor", "necrosis", "factor-alpha", "monocyte", "chemoattractant", "protein-1", "and", "intercellular", "adhesion", "molecule-1"], "h": {"id": "C1413347", "name": "C1413347#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [18, 19]}}
{"token": ["These", "diseases", "include", "multiple", "sclerosis", "rheumatoid", "arthritis", "systemic", "lupus", "erythematosus", "insulin-dependent", "diabetes", "mellitus", "Crohn's", "disease", "coeliac", "disease", "Graves'", "disease", "atrophic", "thyroiditis", "Hashimoto's", "thyroiditis", "myasthenia", "gravis", "chronic", "active", "hepatitis", "C0002170#ent", "<e1>", "uveitis", ",", "vitiligo", ",", "Turner's", "syndrome", "glomerular", "nephritis", "Berger's", "disease", "C1449563#ent", "<e2>"], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1449563", "name": "C1449563#ent", "pos": [40, 41]}}
{"token": ["L-1-Tosylamide-2-phenylethylchloromethyl", "ketone", ",", "on", "the", "other", "hand", ",", "strongly", "inhibited", "protein", "synthesis", "did", "not", "inhibit", "the", "increase", "of", "transglutaminase", "activity", "C0256103#ent", "<e1>", "exposure", ",", "and", "C0059010#ent", "<e2>", "inhibited", "neither", "C0256103#ent", "<e1>", "action", "nor", "protein", "synthesis"], "h": {"id": "C0059010", "name": "C0059010#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [20, 21]}}
{"token": ["Remarkably", ",", "although", "the", "ablation", "of", "C1452523#ent", "<e1>", "cIAP1-CR-mediated", "down-regulation", "of", "cIAP1", "and", "C1332415#ent", "<e2>", ",", "there", "was", "no", "impact", "on", "degradation", "of", "XIAP", "and", "Livin", "."], "h": {"id": "C1452523", "name": "C1452523#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332415", "name": "C1332415#ent", "pos": [13, 14]}}
{"token": ["The", "3alpha-hydroxysteroid", ":", "NAD+-oxidoreductase", "(", "EC", "1.1.1.50", ")", "from", "Pseudomonas", "testosteroni", "ATCC", "11996", ")", "has", "been", "purified", "by", "affinity", "chromatography", "Sepharose", "4B", "C0017905#ent", "<e1>", "ligand", "covalently", "bound", "through", "its", "carboxyl", "group", "the", "C0031957#ent", "<e2>"], "h": {"id": "C0017905", "name": "C0017905#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [32, 33]}}
{"token": ["Only", "one", "of", "55", "patients", "with", "C0085695#ent", "<e1>", "MSI-H", "phenotype", "and", "the", "other", "54", "patients", "showed", "microsatellite", "stable", "C2982447#ent", "<e2>", ")", "phenotypes", "."], "h": {"id": "C0085695", "name": "C0085695#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2982447", "name": "C2982447#ent", "pos": [18, 19]}}
{"token": ["C0036421#ent", "<e1>", "an", "uncommon", "C0559758#ent", "<e2>", "unknown", "aetiology", "which", "predominantly", "affects", "the", "skin", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0559758", "name": "C0559758#ent", "pos": [4, 5]}}
{"token": ["In", "ten", "edematous", "COLD", "patients", "with", "acute", "respiratory", "failure", "C1705280#ent", "<e1>", ")", ",", "we", "monitored", "plasma", "renin", "activity", "C3669212#ent", "<e2>", ")", ",", "aldosterone", "(", "PA", ")", ",", "and", "antidiuretic", "hormone", "arginine", "vasopressin", "AVP", ")", "for", "six", "days", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3669212", "name": "C3669212#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "the", "comorbidities", "presumed", "secondary", "to", "increased", "IAP", "in", "obese", "patients", "include", "congestive", "heart", "failure", "hypoventilation", ",", "venous", "stasis", "ulcers", "gastroesophageal", "reflux", "urinary", "stress", "incontinence", "incisional", "hernia", "C0033845#ent", "<e1>", "proteinuria", ",", "and", "C0020538#ent", "<e2>"], "h": {"id": "C0033845", "name": "C0033845#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [33, 34]}}
{"token": ["The", "disorder", "in", "this", "family", "is", "likely", "to", "represent", "a", "new", "C0039082#ent", "<e1>", "with", "features", "overlapping", "with", "the", "C1852759#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C1852759", "name": "C1852759#ent", "pos": [18, 19]}}
{"token": ["C0124604#ent", "<e1>", "activities", "were", "decreased", "in", "certain", "cases", "of", "C1704876#ent", "<e2>", "(", "OPCA", ")", ",", "but", "conversely", ",", "increased", "in", "CCA", "patients", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704876", "name": "C1704876#ent", "pos": [9, 10]}}
{"token": ["This", "result", "indicates", "that", "the", "C0030935#ent", "<e1>", "the", "main", "intrinsic", "protein", "(", "C1417170#ent", "<e2>", ")", ",", "which", "is", "accessible", "to", "proteolytic", "attack", "very", "likely", "is", "not", "the", "membrane", "attachment", "for", "EEP", "."], "h": {"id": "C0030935", "name": "C0030935#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417170", "name": "C1417170#ent", "pos": [12, 13]}}
{"token": ["Several", "other", "agents", "which", "suppress", "activation", "of", "C2986464#ent", "<e1>", "increased", "BSO", "toxicity", "in", "C1336596#ent", "<e2>"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [13, 14]}}
{"token": ["However", ",", "BSO", "preincubation", "caused", "an", "overproduction", "of", "peroxides", "and", "activation", "of", "C2986464#ent", "<e1>", "and", "AP-1", "in", "C1336596#ent", "<e2>", "in", "the", "absence", "of", "ethanol", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [17, 18]}}
{"token": ["On", "the", "other", "hand", ",", "C0019693#ent", "<e1>", "replication", "strongly", "repressed", "C1417249#ent", "<e2>", "and", "CD163", "expression", ",", "thus", "clearly", "orientating", "macrophages", "towards", "a", "pro-inflammatory", "phenotype", ",", "but", "independently", "of", "TNF", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417249", "name": "C1417249#ent", "pos": [10, 11]}}
{"token": ["Ten", "healthy", "volunteers", "12", "C0751434#ent", "<e1>", "PKU", ")", "heterozygotes", ",", "and", "5", "classic", "C0031485#ent", "<e2>", "have", "been", "loaded", "orally", "with", "a", "mixture", "of", "5", "microCi", "of", "L-[U-14C]phenylalanine", "plus", "25", "mg/kg", "of", "L-[2H5]phenylalanine", "."], "h": {"id": "C0751434", "name": "C0751434#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [13, 14]}}
{"token": ["Based", "on", "these", "observations", ",", "C0751434#ent", "<e1>", "later", "termed", "C0031485#ent", "<e2>", ")", "was", "described", "as", "a", "new", "inborn", "error", "metabolism", "."], "h": {"id": "C0751434", "name": "C0751434#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [9, 10]}}
{"token": ["Also", "the", "alpha-blocking", "agent", "dibenamine", "(", "150", "nmol", ")", "antagonized", ",", "while", "the", "beta-blocker", ",", "C0033497#ent", "<e1>", "(", "100", "nmol", ")", "significantly", "enhanced", "the", "effect", "of", "C0006945#ent", "<e2>", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [26, 27]}}
{"token": ["It", "is", "postulated", "that", "aberrant", "function", "of", "the", "C0020364#ent", "<e1>", "MFOs", ")", "is", "the", "root", "cause", "of", "C0030286#ent", "<e2>"], "h": {"id": "C0020364", "name": "C0020364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030286", "name": "C0030286#ent", "pos": [17, 18]}}
{"token": ["Recently", ",", "serine/threonine", "kinase", "TAK1", "TAK1", "binding", "protein", "1", "2", "(", "TAB1/2", ")", "have", "been", "identified", "as", "molecules", "involved", "in", "IL-1-induced", "TRAF6-mediated", "activation", "of", "C1333571#ent", "<e1>", "and", "NF-kappa", "B", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e2>", "and", "I", "kappa", "B", "kinases", "respectively", "."], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [33, 34]}}
{"token": ["The", "induction", "of", "p65", "binding", "together", "with", "increased", "C0035680#ent", "<e1>", "binding", ",", "confirms", "that", "LMP1-mediated", "activation", "of", "C2825966#ent", "<e2>", "occurs", "transcriptionally", "."], "h": {"id": "C0035680", "name": "C0035680#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2825966", "name": "C2825966#ent", "pos": [17, 18]}}
{"token": ["Serum", "concentrations", "soluble", "C1706544#ent", "<e1>", ",", "VCAM-1", "and", "soluble", "low", "affinity", "receptor", "IgE", "concentrations", "C1414549#ent", "<e2>", "were", "measured", "by", "ELISA", "in", "atopic", "patients", "with", "mild", "asthma", "and", "after", "treatment", "by", "disodium", "cromoglycate", "DSCG", ")", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414549", "name": "C1414549#ent", "pos": [14, 15]}}
{"token": ["C0280950#ent", "<e1>", "the", "p53", "tumor", "suppressor", "gene", "clustered", "in", "the", "four", "so-called", "'", "C0263214#ent", "<e2>", ",", "codons", "175", ",", "248", ",", "273", "and", "281/282", "."], "h": {"id": "C0280950", "name": "C0280950#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0263214", "name": "C0263214#ent", "pos": [13, 14]}}
{"token": ["Pretreatment", "with", "simvastatin", "and", "C0286651#ent", "<e1>", "significantly", "enhanced", "the", "hypotensive", "effect", "of", "C0282138#ent", "<e2>", ",", "while", "that", "with", "pravastatin", "did", "not", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "the", "concomitant", "use", "of", "C0286651#ent", "<e1>", "significantly", "enhanced", "the", "oral", "exposure", "of", "C0282138#ent", "<e2>", "in", "rats", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [15, 16]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "effect", "of", "C0286651#ent", "<e1>", ",", "HMG-CoA", "reductase", "inhibitor", "on", "the", "pharmacokinetics", "of", "C0282138#ent", "<e2>", "and", "its", "active", "metabolite", "desacetyldiltiazem", ",", "in", "rats", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [21, 22]}}
{"token": ["Porcine", "circovirus", "type", "2", "PCV2", ")", "is", "now", "recognised", "as", "the", "causal", "agent", "porcine", "C0043046#ent", "<e1>", "PMWS", ")", ",", "an", "economically", "important", "C0343755#ent", "<e2>", "young", "pigs", "J.", "Vet", "."], "h": {"id": "C0043046", "name": "C0043046#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0343755", "name": "C0343755#ent", "pos": [22, 23]}}
{"token": ["Patients", "at", "significant", "risk", "of", "recurrence", "with", "a", "low", "initial", "C1420709#ent", "<e1>", "level", "then", "have", "C2940785#ent", "<e2>", "stimulation", "testing"], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2940785", "name": "C2940785#ent", "pos": [15, 16]}}
{"token": ["A", "29-year-old", "man", "with", "C0009324#ent", "<e1>", "admitted", "to", "our", "hospital", "because", "of", "C0036572#ent", "<e2>", "and", "a", "headache", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}}
{"token": ["C0012920#ent", "<e1>", "complex", "and", "unique", "C3541394#ent", "<e2>", "which", "alter", "the", "topological", "state", "of", "DNA", "without", "changing", "its", "chemical", "structure"], "h": {"id": "C0012920", "name": "C0012920#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}}
{"token": ["No", "significant", "C0275521#ent", "<e1>", "despite", "the", "fact", "that", "leukopenia", "and", "C1839163#ent", "<e2>", "were", "more", "severe", "and", "frequent", "with", "the", "four-drug", "regimen", "."], "h": {"id": "C0275521", "name": "C0275521#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "the", "role", "of", "genetic", "variants", "the", "main", "C1420598#ent", "<e1>", "AAT", ")", "and", "C3813120#ent", "<e2>", "(", "A2M", "for", "the", "course", "of", "chronic", "pancreatitis"], "h": {"id": "C1420598", "name": "C1420598#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3813120", "name": "C3813120#ent", "pos": [20, 21]}}
{"token": ["Daunorubicin", ",", "C0020789#ent", "<e1>", ",", "aclarubicin", ",", "and", "C0700458#ent", "<e2>", "had", "a", "pronounced", "cytotoxic", "effect", "1", "h", "of", "incubation", "."], "h": {"id": "C0020789", "name": "C0020789#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700458", "name": "C0700458#ent", "pos": [8, 9]}}
{"token": ["Genetic", "susceptibility", "C1858664#ent", "<e1>", "is", "not", "an", "important", "aetiological", "factor", "C0011847#ent", "<e2>", ",", "and", "targeted", "screening", "diabetic", "patients", "for", "C1858664#ent", "<e1>", "is", "not", "indicated", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C1858664", "name": "C1858664#ent", "pos": [2, 3]}}
{"token": ["C0011847#ent", "<e1>", ",", "a", "serious", "complication", "of", "C1858664#ent", "<e2>", ",", "is", "frequently", "associated", "with", "cirrhosis", "which", "reduces", "life", "expectancy"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C1858664", "name": "C1858664#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "C0011847#ent", "<e1>", "is", "still", "a", "frequent", "complication", "of", "C1858664#ent", "<e2>", "in", "Belgium", ",", "and", "its", "presence", "and", "severity", "are", "markedly", "associated", "with", "of", "cirrhosis", "at", "diagnosis", "of", "idiopathic", "haemochromatosis"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C1858664", "name": "C1858664#ent", "pos": [10, 11]}}
{"token": ["Chronic", "fatigue", "arthralgia", ",", "infertility", ",", "impotence", ",", "cardiac", "disease", "C0011847#ent", "<e1>", "and", "abnormality", "of", "liver", "enzymes", "point", "to", "the", "presence", "of", "C1858664#ent", "<e2>", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C1858664", "name": "C1858664#ent", "pos": [22, 23]}}
{"token": ["Agents", "tested", "that", "were", "not", "effective", ",", "except", "at", "very", "high", "concentrations", "(", "100mum", "or", "greater", ")", ",", "were", "C0733903#ent", "<e1>", ",", "Cetab", "and", "C0031412#ent", "<e2>"], "h": {"id": "C0733903", "name": "C0733903#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0031412", "name": "C0031412#ent", "pos": [24, 25]}}
{"token": ["Transcriptional", "elongation", "and", "termination", "by", "RNA", "polymerase", "C0035678#ent", "<e1>", ")", "are", "controlled", "by", "interactions", "among", "the", "nascent", "RNA", ",", "DNA", ",", "and", "C0035678#ent", "<e1>", "that", "comprise", "the", "ternary", "transcription", "elongation", "complex", "C3272493#ent", "<e1>", ")", "."], "h": {"id": "C0035678", "name": "C0035678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3272493", "name": "C3272493#ent", "pos": [31, 32]}}
{"token": ["Although", "C1704875#ent", "<e1>", "is", "induced", "in", "macrophages", "by", "LPS", "or", "IFN-gamma", ",", "the", "combination", ",", "which", "activates", "C1533698#ent", "<e2>", "did", "not", "induce", "C1704875#ent", "<e1>", "."], "h": {"id": "C1533698", "name": "C1533698#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1704875", "name": "C1704875#ent", "pos": [1, 2]}}
{"token": ["A", "C0030568#ent", "<e1>", "be", "an", "extremely", "rare", "manifestation", "of", "C0393968#ent", "<e2>"], "h": {"id": "C0030568", "name": "C0030568#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0393968", "name": "C0393968#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "establish", "the", "influence", "of", "C0242905#ent", "<e1>", "serum", "and", "C1337111#ent", "<e2>", "experimental", "animals"], "h": {"id": "C0242905", "name": "C0242905#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [15, 16]}}
{"token": ["The", "authors", "studied", "the", "effects", "of", "C2745948#ent", "<e1>", "on", "thalamocortical", "relay", "neurons", "in", "a", "ferret", "in", "vitro", "slice", "preparation", "to", "test", "the", "hypothesis", "that", "C2745948#ent", "<e1>", "abolishes", "synchronized", "oscillations", "by", "C0243051#ent", "<e1>", "release", "."], "h": {"id": "C2745948", "name": "C2745948#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [30, 31]}}
{"token": ["Changes", "in", "the", "extracellular", "calcium", "concentration", "altered", "the", "magnitude", "of", "the", "BDNF", "effect", "on", "PPF", "and", "synaptic", "responses", "to", "C2745948#ent", "<e1>", ",", "suggesting", "that", "BDNF", "regulates", "C0243051#ent", "<e2>", "release", "."], "h": {"id": "C2745948", "name": "C2745948#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [26, 27]}}
{"token": ["The", "structural", "gene", "purB", ")", "for", "succinyl-AMP", "(", "S-AMP", ")", "C0024188#ent", "<e1>", "and", "three", "additional", "C0079941#ent", "<e2>", "are", "on", "the", "same", "DNA", "strand", "the", "chromosome", "of", "Escherichia", "coli"], "h": {"id": "C0024188", "name": "C0024188#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}}
{"token": ["These", "studies", "demonstrate", "that", "the", "CD40", "cytoplasmic", "domain", "two", "nonoverlapping", "C1706586#ent", "<e1>", "binding", "regions", "and", "suggest", "that", "TRAF1", ",", "C1366777#ent", "<e2>", ",", "and", "TRAF3", "could", "bind", "competitively", "to", "one", "site", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366777", "name": "C1366777#ent", "pos": [19, 20]}}
{"token": ["The", "elicitation", "of", "a", "blanching", "reaction", "human", "skin", "by", "C0040866#ent", "<e1>", "not", "altered", "in", "the", "presence", "of", "C0086620#ent", "<e2>"], "h": {"id": "C0040866", "name": "C0040866#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086620", "name": "C0086620#ent", "pos": [17, 18]}}
{"token": ["However", ",", "S.", "aureus", "strains", ",", "isolated", "from", "bovine", "milk", "should", "be", "tested", "for", "C0005244#ent", "<e1>", "production", "prior", "to", "treating", "C0164196#ent", "<e2>", "cases", "with", "beta-lactam", "drugs"], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0164196", "name": "C0164196#ent", "pos": [20, 21]}}
{"token": ["We", "hypothesized", "that", "C1414863#ent", "<e1>", "alteration", "of", "estrogen", "receptor", "ER", ")", "binding", "to", "DNA", "and", "C1425190#ent", "<e2>", "may", "be", "one", "mechanism", "by", "which", "it", "exerts", "its", "chemopreventive", "effects"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425190", "name": "C1425190#ent", "pos": [15, 16]}}
{"token": ["C3540781#ent", "<e1>", "are", "the", "standard", "C0729502#ent", "<e2>", "malignant", "brain", "tumors"], "h": {"id": "C3540781", "name": "C3540781#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [5, 6]}}
{"token": ["It", "was", "proved", "in", "the", "1980s", "that", "human", "C0854530#ent", "<e1>", "and", "human", "parvovirus", "B19", "cause", "C0012634#ent", "<e2>", "in", "humans", "."], "h": {"id": "C0854530", "name": "C0854530#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["The", "C0011847#ent", "<e1>", "resulted", "in", "marked", "decrease", "in", "C0033384#ent", "<e2>", "EC", "1.14.11.2", ")", "activity", "in", "rat", "gingiva", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033384", "name": "C0033384#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "show", "that", "the", "master", "melanocyte", "differentiation", "factor", "microphthalmia", "transcription", "factor", "C1417172#ent", "<e1>", ")", ",", "regulates", "cell", "cycle", "by", "activating", "the", "cell", "cycle", "inhibitor", "C1705280#ent", "<e2>", ",", "a", "tumor", "suppressor", "frequently", "is", "mutated", "in", "melanomas", "."], "h": {"id": "C1417172", "name": "C1417172#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [26, 27]}}
{"token": ["IL-12", "and", "C1881122#ent", "<e1>", "produced", "by", "C0033036#ent", "<e2>", "are", "essential", "for", "inducing", "Th1", "effector", "cells", "."], "h": {"id": "C1881122", "name": "C1881122#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [6, 7]}}
{"token": ["Although", "the", "patient", "was", "treated", "with", "courses", "of", "combination", "chemotherapy", "vincristine", ",", "C0014582#ent", "<e1>", ",", "cyclophosphamide", ",", "methylprednisolone", ")", ",", "he", "died", "of", "C0264490#ent", "<e2>", "months", "after", "diagnosis", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "a", "case", "of", "C1852540#ent", "<e1>", "a", "44-yr", "old", "menstruating", "woman", "with", "C0026267#ent", "<e2>", "who", "experienced", "acute", "myocardial", "infarction", "twisting", "and", "throwing", "a", "heavy", "piece", "of", "luggage", "."], "h": {"id": "C1852540", "name": "C1852540#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026267", "name": "C0026267#ent", "pos": [13, 14]}}
{"token": ["The", "yeast", "transcriptional", "activator", "C1332102#ent", "<e1>", "contains", "a", "DNA-binding", "domain", "to", "C3541252#ent", "<e2>", ",", "PPR1", ",", "and", "related", "factors", "."], "h": {"id": "C1332102", "name": "C1332102#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541252", "name": "C3541252#ent", "pos": [11, 12]}}
{"token": ["We", "demonstrate", "the", "method", "on", "four", "examples", ":", "HIV", "proteases", "two-domain", "acid", "proteases", ",", "thrombin", "versus", "trypsin", "and", "factor", "Xa", "C0039667#ent", "<e1>", "DHFRs", ")", "versus", "vertebrate", "DHFRs", ",", "and", "P38", "versus", "C0033640#ent", "<e2>"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [31, 32]}}
{"token": ["C1142738#ent", "<e1>", "is", "a", "new", "C1268551#ent", "<e2>", "that", "acts", "by", "inhibiting", "(1,3)-beta-D-glucan", "synthesis", "in", "the", "fungal", "cell", "wall"], "h": {"id": "C1142738", "name": "C1142738#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C1268551", "name": "C1268551#ent", "pos": [5, 6]}}
{"token": ["On", "the", "other", "hand", ",", "the", "activity", "of", "C1416902#ent", "<e1>", "decreased", "in", "the", "C0023816#ent", "<e2>", "adipose", "tissue", "3", "postintoxication", ",", "and", "decreased", "significantly", "after", "16", "hr", "."], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [13, 14]}}
{"token": ["The", "three", "sites", "on", "phage", "lambda", "DNA", "different", "from", "those", "cleaved", "by", "C0026847#ent", "<e1>", "Xma", "I", "and", "C1704669#ent", "<e2>"], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704669", "name": "C1704669#ent", "pos": [17, 18]}}
{"token": ["The", "C1431040#ent", "<e1>", "MLK", ")", "family", "is", "a", "recently", "described", "C0031727#ent", "<e2>"], "h": {"id": "C1431040", "name": "C1431040#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}}
{"token": ["C1431040#ent", "<e1>", "MLKs", ")", "function", "as", "Jun-N-terminal", "kinase", "JNK", ")", "C0031727#ent", "<e2>", "transduce", "extracellular", "signals", "during", "development", "and", "homeostasis", "in", "adults", "."], "h": {"id": "C1431040", "name": "C1431040#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}}
{"token": ["The", "C1431040#ent", "<e1>", "family", "of", "mitogen", "activated", "C0031727#ent", "<e2>", "MAPKKK", ")", "has", "been", "shown", "to", "activate", "Jun", "N-terminal", "kinase/stress-activated", "protein", "kinase", "1", "JNK/SAPK1", ")", "."], "h": {"id": "C1431040", "name": "C1431040#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "C3540534#ent", "<e1>", "may", "be", "of", "therapeutic", "use", ",", "especially", "in", "C0035309#ent", "<e2>", "where", "pathological", "neovascularization", "compromises", "vision", "and", "leads", "to", "blindness", "."], "h": {"id": "C3540534", "name": "C3540534#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035309", "name": "C0035309#ent", "pos": [14, 15]}}
{"token": ["C0282398#ent", "<e1>", ",", "another", "important", "C0003374#ent", "<e2>", "associated", "with", "polymer", "in", "a", "similar", "fashion", ",", "both", "in", "cultured", "parasites", "and", "in", "the", "test", "tube"], "h": {"id": "C0282398", "name": "C0282398#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [5, 6]}}
{"token": ["The", "effect", "of", "C0282398#ent", "<e1>", "on", "choline/Mg2", "+", "antiport", "in", "vitro", "not", "related", "to", "the", "C0003374#ent", "<e2>", "C0282398#ent", "<e1>", "in", "vivo"], "h": {"id": "C0282398", "name": "C0282398#ent", "pos": [3, 4]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [15, 16]}}
{"token": ["To", "gain", "insights", "into", "the", "mechanisms", "by", "which", "class", "A", "C3539876#ent", "<e1>", "cell", "growth", "we", "have", "investigated", "their", "role", "in", "the", "C1710463#ent", "<e2>", "cyclin-dependent", "kinase", "inhibitors"], "h": {"id": "C3539876", "name": "C3539876#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [21, 22]}}
{"token": ["A", "linear", "mitochondrial", "plasmid", "pEM", ",", "found", "in", "certain", "C1875400#ent", "<e1>", "of", "the", "basidiomycete", "Agaricus", "bitorquis", ",", "potentially", "encodes", "virus-like", "DNA", "C0035681#ent", "<e2>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [21, 22]}}
{"token": ["Fingernail", "growth", "studied", "in", "28", "patients", "who", "were", "receiving", "systemic", "treatment", "the", "C0035339#ent", "<e1>", "Ro", "10", "9359", "known", "as", "Tigason", "(", "C0050559#ent", "<e2>", ";", "AR", ")", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [12, 13]}, "relation": "chemical_structure_of", "t": {"id": "C0050559", "name": "C0050559#ent", "pos": [21, 22]}}
{"token": ["Myocarditis", "sometimes", "occurs", "as", "a", "complication", "of", "C0004623#ent", "<e1>", "including", "enteric", "infections", "by", "Salmonella", ",", "C0013371#ent", "<e2>", "and", "Yersinia", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013371", "name": "C0013371#ent", "pos": [15, 16]}}
{"token": ["Sequencing", "of", "the", "nucleomorph", "genome", "that", "it", "encodes", "an", "C0013570#ent", "<e1>", "homologous", "to", "the", "C0080054#ent", "<e2>", ",", "supporting", "the", "hypothesis", "that", "FtsZ", "is", "common", "in", "chloroplasts", "."], "h": {"id": "C0013570", "name": "C0013570#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [14, 15]}}
{"token": ["C3854181#ent", "<e1>", "SN", ")", "syndrome", "is", "a", "neurocutaneous", "disorder", "by", "a", "distinctive", "C0037284#ent", "<e2>", "association", "with", "epilepsy", "and", "mental", "retardation"], "h": {"id": "C3854181", "name": "C3854181#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [12, 13]}}
{"token": ["The", "authors", "present", "a", "case", "of", "C3854181#ent", "<e1>", "a", "patient", "with", "C0037284#ent", "<e2>", "approximately", "80", "%", "of", "the", "total", "body", "surface", "area"], "h": {"id": "C3854181", "name": "C3854181#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [11, 12]}}
{"token": ["C0733682#ent", "<e1>", "the", "most", "prevalent", "inherited", "form", "of", "C0035579#ent", "<e2>", "."], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [8, 9]}}
{"token": ["X-linked", "hypophosphatemic", "rickets", "C0733682#ent", "<e1>", ")", "is", "one", "of", "the", "most", "common", "causes", "of", "C0035579#ent", "<e2>", "in", "infancy", "and", "childhood", "."], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [14, 15]}}
{"token": ["The", "C0733682#ent", "<e1>", "mouse", "manifests", "C0035579#ent", "<e2>", "and", "renal", "wasting", "phosphorus", "."], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [5, 6]}}
{"token": ["We", "conclude", "that", "SH-PTP1", "might", "represent", "a", "critical", "C0014442#ent", "<e1>", "in", "the", "complex", "interplay", "between", "the", "various", "C1336692#ent", "<e2>", "phosphorylation", "in", "the", "cytoskeletal", "matrix"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1336692", "name": "C1336692#ent", "pos": [17, 18]}}
{"token": ["The", "gene", "encoding", "C1367701#ent", "<e1>", "was", "linked", "to", "at", "least", "three", "other", "C1417679#ent", "<e2>", "encoding", "enzymes", "of", "the", "folate", "pathway"], "h": {"id": "C1367701", "name": "C1367701#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Subcutaneous", "deposition", "of", "C1412709#ent", "<e1>", "beta", "2-M", ")", "amyloid", "is", "an", "uncommon", "finding", "in", "C0041948#ent", "<e2>", "patients", "on", "long-term", "haemodialysis", "."], "h": {"id": "C1412709", "name": "C1412709#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [14, 15]}}
{"token": ["The", "plantain", "flour-based", "solution", "proved", "effective", "for", "the", "treatment", "of", "dehydration", "due", "to", "C0013369#ent", "<e1>", "should", "be", "considered", "as", "an", "alternative", "when", "standard", "C0078516#ent", "<e2>", "is", "not", "available", "."], "h": {"id": "C0013369", "name": "C0013369#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0078516", "name": "C0078516#ent", "pos": [23, 24]}}
{"token": ["A", "middle-aged", "female", "with", "C0003873#ent", "<e1>", "commenced", "on", "C0021246#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "5-CT", ",", "5-HT", "and", "metoclopramide", "caused", "concentration-dependent", "relaxations", "in", "the", "presence", "of", "10(-6", ")", "M", "C0022616#ent", "<e1>", "in", "the", "C0024228#ent", "<e2>", "contraction", "with", "prostaglandin", "F2", "alpha"], "h": {"id": "C0022616", "name": "C0022616#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0024228", "name": "C0024228#ent", "pos": [22, 23]}}
{"token": ["Our", "results", "suggest", "that", "C1333196#ent", "<e1>", "transcriptional", "pathways", "misregulated", "in", "attack-free", "C1417104#ent", "<e2>", "patients", ",", "and", "further", "supports", "the", "hypothesis", "that", "these", "patients", "have", "subclinical", "inflammation", "attacks", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417104", "name": "C1417104#ent", "pos": [11, 12]}}
{"token": ["Myristoylated", "alanine-rich", "C", "kinase", "substrate", "MARCKS", ")", ",", "an", "acidic", "protein", "associated", "with", "cell", "motility", "phagocytosis", ",", "is", "activated", "upon", "phosphorylation", "by", "C0033634#ent", "<e1>", "PKC", ")", "and", "C0084209#ent", "<e2>"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0084209", "name": "C0084209#ent", "pos": [27, 28]}}
{"token": ["Incubation", "of", "human", "neutrophils", "with", "FMLP", ",", "a", "chemotactic", "peptide", "or", "PMA", ",", "a", "stimulator", "of", "C0033634#ent", "<e1>", "resulted", "in", "the", "activation", "of", "p38", ",", "a", "C0084209#ent", "<e2>"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0084209", "name": "C0084209#ent", "pos": [26, 27]}}
{"token": ["Resonances", "not", "previously", "observed", "in", "spectra", "of", "plasma", "from", "healthy", "volunteers", "seen", "in", "CRF", "plasma", ",", "including", "those", "for", "trimethylamine-N-oxide", "(", "C0077194#ent", "<e1>", ")", "and", "dimethylamine", "(", "C0301360#ent", "<e2>", ")", "."], "h": {"id": "C0077194", "name": "C0077194#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0301360", "name": "C0301360#ent", "pos": [27, 28]}}
{"token": ["Adsorption", "of", "the", "imidazolinone", "herbicides", "C0172218#ent", "<e1>", ",", "imazethapyr", ",", "and", "C0635449#ent", "<e2>", "on", "synthetic", "ferrihydrites", ",", "either", "freeze-dried", "or", "not-freeze-dried", ",", "has", "been", "studied", "."], "h": {"id": "C0172218", "name": "C0172218#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0635449", "name": "C0635449#ent", "pos": [11, 12]}}
{"token": ["Pseudomonas", "sp.", "strain", "C1412610#ent", "<e1>", "grew", "with", "dl-tropic", "acid", ",", "the", "aromatic", "component", "the", "alkaloid", "C0004259#ent", "<e2>", ",", "as", "the", "sole", "source", "of", "carbon", "and", "energy", "."], "h": {"id": "C1412610", "name": "C1412610#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [15, 16]}}
{"token": ["Development", "of", "the", "C1417023#ent", "<e1>", "requires", "the", "function", "of", "a", "diverse", "set", "of", "C0017337#ent", "<e2>", "encoding", "transcription", "factors", "signaling", "molecules", "and", "their", "receptors", "."], "h": {"id": "C1417023", "name": "C1417023#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["We", "then", "evaluated", "the", "involvement", "of", "C1417023#ent", "<e1>", "in", "SD", "by", "further", "screening", "of", "the", "C0017337#ent", "<e2>", "in", "several", "patients", "with", "a", "similar", "phenotype", "."], "h": {"id": "C1417023", "name": "C1417023#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["However", ",", "recent", "reports", "have", "identified", "a", "degenerative", "disease", "Fragile", "X-associated", "Tremor/Ataxia", "Syndrome", "C1839780#ent", "<e1>", ")", "in", "older", "men", "as", "well", "as", "C0085215#ent", "<e2>", "women", "."], "h": {"id": "C1839780", "name": "C1839780#ent", "pos": [13, 14]}, "relation": "has_manifestation", "t": {"id": "C0085215", "name": "C0085215#ent", "pos": [22, 23]}}
{"token": ["The", "R141H", "mutation", "in", "the", "C1418674#ent", "<e1>", "the", "most", "frequent", "mutation", "in", "type", "Ia", "of", "the", "C0543793#ent", "<e2>", "glycosylation", "(", "formerly", "carbohydrate-deficient", "glycoprotein", "syndromes)(CDG-Ia", "."], "h": {"id": "C1418674", "name": "C1418674#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0543793", "name": "C0543793#ent", "pos": [16, 17]}}
{"token": ["Demethylation", "treatment", "by", "5'aza-deoxycytidine", "restored", "C3275256#ent", "<e1>", "expression", "and", "also", "suppressed", "C0669365#ent", "<e2>", "STAT3", "phosphorylation", "in", "AGS", "cells", "."], "h": {"id": "C3275256", "name": "C3275256#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["One", "major", "protein", "specifically", "recruited", "on", "the", "InlB-phagosomes", "was", "identified", "by", "mass", "spectrometry", "C1418891#ent", "<e1>", ",", "a", "previously", "reported", "member", "of", "the", "septin", "family", "C0018296#ent", "<e2>", "."], "h": {"id": "C1418891", "name": "C1418891#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [24, 25]}}
{"token": ["These", "are", "RNA", "viruses", "have", "the", "capacity", "to", "make", "DNA", "copies", "their", "characteristic", "enzyme", ",", "C1955880#ent", "<e1>", "encoded", "in", "the", "pole", "region", "the", "C0042720#ent", "<e2>"], "h": {"id": "C1955880", "name": "C1955880#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0042720", "name": "C0042720#ent", "pos": [23, 24]}}
{"token": ["Treatment", "with", "the", "PAR-1", "antagonist", "SCH79797", "confirms", "that", "C0041236#ent", "<e1>", "selectively", "activates", "C1366449#ent", "<e2>", "in", "rat", "astrocytes", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366449", "name": "C1366449#ent", "pos": [12, 13]}}
{"token": ["As", "an", "anticholinergic", "drug", "C0055146#ent", "<e1>", "is", "at", "least", "400", "times", "weaker", "than", "C0004259#ent", "<e2>", "."], "h": {"id": "C0055146", "name": "C0055146#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [13, 14]}}
{"token": ["Although", "an", "individual", "patient", "may", "respond", "to", "a", "C1254351#ent", "<e1>", ",", "in", "general", "patients", "with", "C1868193#ent", "<e2>", "have", "a", "minimal", "response", "and", "a", "short", "duration", "of", "sustained", "benefit", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1868193", "name": "C1868193#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", "normeperidine", "formation", "in", "human", "liver", "microsomes", "is", "mainly", "catalyzed", "by", "C1828468#ent", "<e1>", "and", "CYP3A4", ",", "with", "a", "minor", "contribution", "from", "C1332828#ent", "<e2>", "."], "h": {"id": "C1828468", "name": "C1828468#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332828", "name": "C1332828#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "various", "C1562036#ent", "<e1>", "ventricular", "arrhythmias", "particularly", "fibrillation", "(", "C0042510#ent", "<e2>", ")", ",", "in", "relation", "to", "epicardial", "conduction", "delay", "during", "acute", "myocardial", "ischaemia", "reperfusion", "were", "investigated", "in", "40", "open-chest", "anaesthetized", "dogs", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [11, 12]}}
{"token": ["Targeted", "mutations", "C1310668#ent", "<e1>", "in", "the", "mouse", "reveal", "an", "essential", "role", "of", "the", "C0017337#ent", "<e2>", "in", "male", "fertility", "."], "h": {"id": "C1310668", "name": "C1310668#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["C1333237#ent", "<e1>", "examined", "in", "the", "c-abl", "and", "C0079067#ent", "<e2>", "UV-irradiated", "mouse", "3T3", "fibroblasts", "using", "an", "optimized", "assay", "for", "measuring", "pyrimidine", "dimers", "single-copy", "nucleotide", "sequences"], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079067", "name": "C0079067#ent", "pos": [7, 8]}}
{"token": ["This", "case", "report", "the", "fact", "that", "the", "C0521942#ent", "<e1>", "losartan", "can", "cause", "serious", "unexpected", "complications", "in", "patients", "with", "C0268790#ent", "<e2>", "should", "be", "used", "with", "extreme", "caution", "in", "this", "setting", "."], "h": {"id": "C0521942", "name": "C0521942#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [18, 19]}}
{"token": ["Those", "microtrauma", "may", "be", "due", "to", "pathological", "hairs", "on", "caruncle", "or", "in", "inner", "canthus", "rarely", "due", "to", "concretion", "of", "Meibaumian", "glands", "granulomas", ",", "C0007933#ent", "<e1>", "lacrymal", "points", ",", "cysts", "and", "C1705714#ent", "<e2>", "."], "h": {"id": "C0007933", "name": "C0007933#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1705714", "name": "C1705714#ent", "pos": [30, 31]}}
{"token": ["Deletion", "mutants", "of", "C1415782#ent", "<e1>", ",", "lacking", "the", "N-terminal", "137", ",", "243", "or", "359", "C3539947#ent", "<e2>", "strongly", "inhibited", "C1415782#ent", "<e1>", "binding", "to", "macrophages", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1415782", "name": "C1415782#ent", "pos": [3, 4]}}
{"token": ["The", "changes", "in", "C0017868#ent", "<e1>", "and", "[Ca]'i", "after", "stimulation", "with", "C0006945#ent", "<e2>", "were", "correlated", "and", "ionomycin", "also", "increased", "C0017868#ent", "<e1>", "and", "[Ca]'i", "in", "a", "parallel", "manner", "."], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [10, 11]}}
{"token": ["Following", "surgery", "for", "a", "chronic", "subdural", "haematoma", "a", "74-year-old", "patient", "received", "C0284906#ent", "<e1>", "as", "prophylaxis", "for", "C0014544#ent", "<e2>", "."], "h": {"id": "C0284906", "name": "C0284906#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [16, 17]}}
{"token": ["To", "investigate", "the", "effects", "of", "C0054836#ent", "<e1>", "on", "neurohormone", "and", "magnesium", "metabolism", "patients", "with", "chronic", "heart", "failure", "C0019099#ent", "<e2>", ")", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [17, 18]}}
{"token": ["As", "in", "central", "areas", "the", "turnover", "rates", "DOPAC", "and", "HVA", "calculated", "on", "the", "basis", "of", "the", "greatest", "accumulation", "of", "acidic", "levels", "C0033209#ent", "<e1>", "were", "much", "smaller", "than", "those", "obtained", "after", "C0030557#ent", "<e2>", "."], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0030557", "name": "C0030557#ent", "pos": [30, 31]}}
{"token": ["It", "was", "confirmed", "that", "C0052527#ent", "<e1>", "was", "also", "extracted", "by", "C0146951#ent", "<e2>", "a", "molecular", "form", "was", "excluded", "from", "Sepharose", "4B"], "h": {"id": "C0052527", "name": "C0052527#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [10, 11]}}
{"token": ["In", "previous", "studies", ",", "we", "demonstrated", "that", "C1419798#ent", "<e1>", "stimulated", "the", "production", "of", "C1710304#ent", "<e2>", ",", "IL-1beta", ",", "IL-8", ",", "NO", ",", "and", "ROS", "by", "neutrophils", "and/or", "mononuclear", "cells"], "h": {"id": "C1419798", "name": "C1419798#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [13, 14]}}
{"token": ["A", "diagnosis", "of", "C0403529#ent", "<e1>", "made", "and", "treatment", "was", "started", "with", "prednisone", ",", "C1161438#ent", "<e2>", "and", "periodic", "plasmapheresis", "complete", "progressive", "disappearance", "of", "circulating", "anti-glomerular", "basement", "membrane", "antibody"], "h": {"id": "C0403529", "name": "C0403529#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [13, 14]}}
{"token": ["A", "49", "year-old", "women", "with", "a", "2-year", "history", "of", "a", "C0520736#ent", "<e1>", "hospitalized", "with", "C0342124#ent", "<e2>", "thyrotoxic", "crisis", "."], "h": {"id": "C0520736", "name": "C0520736#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0342124", "name": "C0342124#ent", "pos": [14, 15]}}
{"token": ["C1332017#ent", "<e1>", "(", "named", "for", "a", "disintegrin", "and", "metalloprotease", "15", "C1313290#ent", "<e2>", ")", "is", "a", "membrane-anchored", "glycoprotein", "has", "been", "implicated", "in", "cell-cell", "or", "cell-matrix", "interactions", "in", "the", "proteolysis", "of", "molecules", "on", "the", "cell", "surface", "extracellular", "matrix"], "h": {"id": "C1332017", "name": "C1332017#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1313290", "name": "C1313290#ent", "pos": [10, 11]}}
{"token": ["In", "C1145628#ent", "<e1>", "drug", "intake", "spices", "and", ",", "to", "a", "less", "extent", ",", "C0001975#ent", "<e2>", "and/or", "stress", "situations", "play", "a", "more", "important", "role", "."], "h": {"id": "C1145628", "name": "C1145628#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [13, 14]}}
{"token": ["C3540778#ent", "<e1>", "are", "potent", "inducers", "of", "C1176140#ent", "<e2>", "in", "humans", "."], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [6, 7]}}
{"token": ["However", ",", "a", "synergistic", "induction", "of", "C1176140#ent", "<e1>", "has", "been", "observed", "with", "physiological", "doses", "C3540778#ent", "<e2>", "and", "other", "C1176140#ent", "<e1>", "inducers", "."], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [6, 7]}}
{"token": ["Epiduroscopy", "is", "a", "relatively", "new", "diagnostic", "and", "therapeutic", "technique", "in", "patients", "with", "C0457949#ent", "<e1>", "or", "without", "C0700594#ent", "<e2>", "."], "h": {"id": "C0457949", "name": "C0457949#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0700594", "name": "C0700594#ent", "pos": [16, 17]}}
{"token": ["The", "C0079429#ent", "<e1>", "for", "C0040085#ent", "<e2>", "thyA", ")", "followed", "thrC", "and", "the", "C0079429#ent", "<e1>", "for", "aspartate", "aminotransferase", "aspC", ")", "preceded", "hom", "."], "h": {"id": "C0040085", "name": "C0040085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}}
{"token": ["Elongation", "factor", "C0059036#ent", "<e1>", ")", "1A", "also", "associates", "to", "the", "MSC", ",", "with", "C1424741#ent", "<e2>", "possibly", "acting", "as", "a", "core", "protein"], "h": {"id": "C0059036", "name": "C0059036#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424741", "name": "C1424741#ent", "pos": [13, 14]}}
{"token": ["To", "form", "a", "functional", "receptor", "entity", ",", "GABAB", "receptors", "exist", "as", "a", "heterodimer", "consisting", "of", "C1414900#ent", "<e1>", "and", "GABAB2", "receptor", "subtypes", "with", "two", "C0021699#ent", "<e2>", "and", "these", "subunits", "arise", "from", "distinct", "genes", "."], "h": {"id": "C1414900", "name": "C1414900#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [23, 24]}}
{"token": ["The", "results", "indicated", "focal", "positivity", "for", "CEA", ",", "C1423594#ent", "<e1>", "lack", "of", "immunostaining", "for", "C1414461#ent", "<e2>", "and", "PR", "and", "Ki67", "positivity", "with", "a", "low", "index", "proliferation", "."], "h": {"id": "C1423594", "name": "C1423594#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [14, 15]}}
{"token": ["Treatment", "with", "C0002144#ent", "<e1>", "did", "not", "affect", "the", "HGRPT", "and", "C0001414#ent", "<e2>", "activities", "."], "h": {"id": "C0002144", "name": "C0002144#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001414", "name": "C0001414#ent", "pos": [10, 11]}}
{"token": ["A", "potent", "mediator", "of", "inflammatory", "responses", "ET", "has", "been", "detected", "in", "middle", "ear", "effusions", "patients", "with", "C0029882#ent", "<e1>", "effusion", "and", "C0271454#ent", "<e2>", "and", "used", "to", "induce", "inflammation", "of", "the", "middle", "ear", "mucosa", "disruption", "of", "mucociliary", "transport", "experimental", "animals"], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0271454", "name": "C0271454#ent", "pos": [20, 21]}}
{"token": ["One", "of", "the", "new", "C0086376#ent", "<e1>", "was", "a", "major", "phosphotyrosyl", "substrate", "76", "-", "85", "kDa", "(", "C1708432#ent", "<e2>", ")", "that", "was", "directly", "associated", "with", "p85", "subunit", "of", "phosphatidylinositol", "PI", ")", "3-kinase", "through", "the", "SH2", "domains", "p85", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1708432", "name": "C1708432#ent", "pos": [16, 17]}}
{"token": ["The", "activities", "of", "acid", "deoxyribonuclease", "cathepsin", "C", "cathepsin", "D", "and", "C0028189#ent", "<e1>", "as", "well", "as", "the", "activities", "of", "citrate", "synthase", "C1537985#ent", "<e2>", "mitochondrial", "enzymes", "were", "unaffected", "in", "cardiac", "muscle"], "h": {"id": "C0028189", "name": "C0028189#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [20, 21]}}
{"token": ["There", "is", "a", "relationship", "between", "the", "local", "lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "concentration", "in", "C0155490#ent", "<e2>", "and", "local", "bone", "resorption", "chronic", "otitis", "media", "COM", ")", "with", "C0155490#ent", "<e2>", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0155490", "name": "C0155490#ent", "pos": [14, 15]}}
{"token": ["The", "decreased", "extent", "of", "inhibition", "is", "accounted", "for", "by", "residua", "of", "unreacted", "and", "undegraded", "heparin", "cofactor", "C1414504#ent", "<e1>", ",", "as", "demonstrated", "by", "gel", "electrophoresis", "C0058632#ent", "<e2>"], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0058632", "name": "C0058632#ent", "pos": [24, 25]}}
{"token": ["Only", "a", "few", "cases", "of", "resistance", "to", "C0022625#ent", "<e1>", "were", "found", "in", "patients", "with", "C0006845#ent", "<e2>", "CMC", ")", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0006845", "name": "C0006845#ent", "pos": [14, 15]}}
{"token": ["It", "is", "only", "rarely", "that", "insulin-dependent", "diabetes", "results", "from", "a", "pure", "C0042769#ent", "<e1>", "as", "part", "of", "polyendocrine", "autoimmune", "C0268487#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [18, 19]}}
{"token": ["We", "suggest", "that", "a", "C0272242#ent", "<e1>", "including", "isolated", "C1332655#ent", "<e2>", "should", "be", "ruled", "out", "in", "all", "cases", "of", "relapsing", "meningitis"], "h": {"id": "C0272242", "name": "C0272242#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C1332655", "name": "C1332655#ent", "pos": [8, 9]}}
{"token": ["No", "significant", "activity", "was", "observed", "when", "using", "sulfadoxine-pyrimethamine", ",", "quinacrine", ",", "trimethoprim-sulfamethoxazole", ",", "bleomycin", ",", "C0100593#ent", "<e1>", ",", "daunorubicin", ",", "pentamidine", ",", "C0002260#ent", "<e2>", ",", "diclazuril", "or", "N-methylglucamine", "."], "h": {"id": "C0100593", "name": "C0100593#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002260", "name": "C0002260#ent", "pos": [22, 23]}}
{"token": ["Characteristic", "findings", "were", "acquired", "in", "parkinsonism", ",", "choreatic", ",", "C1857093#ent", "<e1>", "athetotic", "syndromes", ",", "ballism", ",", "Wilson's", "disease", "drug", "induced", "C0013384#ent", "<e2>", "as", "well", "as", "other", "hyperkinetic", "syndromes"], "h": {"id": "C1857093", "name": "C1857093#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [20, 21]}}
{"token": ["The", "visceral", "and", "the", "different", "spectrum", "of", "C1328252#ent", "<e1>", "been", "incriminated", "to", "be", "among", "the", "opportunistic", "infections", "with", "C2963174#ent", "<e2>", "."], "h": {"id": "C1328252", "name": "C1328252#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2963174", "name": "C2963174#ent", "pos": [18, 19]}}
{"token": ["Comparison", "of", "the", "kinetic", "properties", "of", "C3890378#ent", "<e1>", "for", "retinal", "isomers", "those", "of", "previously", "reported", "rat", "C0073099#ent", "<e2>", "distinct", "differences", ",", "suggesting", "that", "C3890378#ent", "<e1>", "may", "play", "a", "different", "role", "in", "retinal", "metabolism", "liver", "."], "h": {"id": "C0073099", "name": "C0073099#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3890378", "name": "C3890378#ent", "pos": [6, 7]}}
{"token": ["This", "review", "will", "concentrate", "on", "the", "use", "of", "one", "of", "the", "newer", "compounds", "in", "this", "category", ",", "C0071304#ent", "<e1>", ",", "in", "the", "treatment", "of", "C0020538#ent", "<e2>"], "h": {"id": "C0071304", "name": "C0071304#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [24, 25]}}
{"token": ["Thus", ",", "all", "above", "enables", "to", "recommend", "C0071304#ent", "<e1>", "(", "Lomir", ")", "as", "effective", "and", "safe", "method", "correcting", "C0020538#ent", "<e2>", "drivers", "."], "h": {"id": "C0071304", "name": "C0071304#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["To", "observe", "the", "association", "between", "single", "nucleotide", "polymorphism", "SNP", ")", "of", "peroxisome", "proliferators-activated", "receptor-gamma", "coactivator-1alpha", "C1418779#ent", "<e1>", ")", "gene", "and", "C0011860#ent", "<e2>", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [20, 21]}}
{"token": ["C1418779#ent", "<e1>", "is", "involved", "in", "the", "pathophysiology", "of", "obesity", "and", "C0011860#ent", "<e2>"], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [10, 11]}}
{"token": ["Several", "PARP", "inhibitors", "benzamide", ",", "3-aminobenzamide", ",", "nicotinamide", ",", "and", "C0070540#ent", "<e1>", "]", "prevented", "cell", "death", "but", "the", "inactive", "C0053225#ent", "<e2>", "not", "."], "h": {"id": "C0070540", "name": "C0070540#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0053225", "name": "C0053225#ent", "pos": [19, 20]}}
{"token": ["Short", "and", "long", "term", "administration", "of", "C0042402#ent", "<e1>", "patients", "with", "pulmonary", "artery", "hypertension", "C1367456#ent", "<e2>", ")", "effects", "small", "falls", "of", "C1367456#ent", "<e2>", "and", "larger", "reductions", "of", "pulmonary", "vascular", "resistance", "to", "increases", "of", "cardiac", "output"], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1367456", "name": "C1367456#ent", "pos": [13, 14]}}
{"token": ["C1417048#ent", "<e1>", "prepared", "by", "mixing", "it", "with", "hydroxypropylmethylcellulose", "(", "C0063242#ent", "<e2>", ")", "in", "different", "ratio", ",", "results", "in", "improved", "riboflavin-release", "properties", "."], "h": {"id": "C1417048", "name": "C1417048#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0063242", "name": "C0063242#ent", "pos": [9, 10]}}
{"token": ["Monoclonal", "IgM", "binding", "to", "TS-HDS", "is", "associated", "with", "painful", ",", "predominantly", "sensory", ",", "C0152025#ent", "<e1>", "axonal", "loss", "deposition", "of", "C1706005#ent", "<e2>", "in", "veins", "."], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [19, 20]}}
{"token": ["Comparing", "X-ray", "findings", ",", "ultrasound", "and", "drug", "echography", "a", "C0012798#ent", "<e1>", "allows", "one", "to", "differentiate", "cavernous", "nephrotuberculosis", "from", "C0054757#ent", "<e2>", "and", "their", "combinations", "with", "confidence", "."], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0054757", "name": "C0054757#ent", "pos": [18, 19]}}
{"token": ["Mutations", "affecting", "heteroduplex", "DNA", "mismatch", "repair", "Streptococcus", "pneumoniae", "localized", "in", "two", "genes", ",", "C1327841#ent", "<e1>", "and", "hexB", ",", "by", "fractionation", "of", "restriction", "fragments", "mutant", "C0002085#ent", "<e2>", "."], "h": {"id": "C1327841", "name": "C1327841#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [24, 25]}}
{"token": ["To", "determine", "the", "sequence", "of", "critical", "cardiovascular", "events", "the", "progression", "of", "C0018802#ent", "<e1>", "and", "whether", "aetiology", "or", "high-dose", "vs", "low-dose", "C0065374#ent", "<e2>", "affected", "these", "pathways", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [20, 21]}}
{"token": ["In", "this", "paper", "we", "have", "identified", "a", "new", "myosin-VI-binding", "partner", ",", "C2348192#ent", "<e1>", "LMTK2", ")", ",", "which", "is", "the", "first", "transmembrane", "protein", "C0031727#ent", "<e2>", "that", "directly", "binds", "to", "myosin", "VI"], "h": {"id": "C2348192", "name": "C2348192#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}}
{"token": ["Brek/Lmtk2", "(", "C2348192#ent", "<e1>", "is", "a", "member", "of", "the", "Aatyk", "family", "of", "C0031727#ent", "<e2>", "that", "comprises", "Aatyk1", ",", "Brek/Lmtk2/Aatyk2", ",", "and", "Aatyk3", "."], "h": {"id": "C2348192", "name": "C2348192#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "effect", "of", "ciglitazone", "(", "CG", ")", ",", "a", "PPARgamma", "inducer", ",", "on", "C2698414#ent", "<e1>", "and", "TxA(2", ")", "production", "and", "activity", "in", "glycerol-induced", "C0035436#ent", "<e2>", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0035436", "name": "C0035436#ent", "pos": [29, 30]}}
{"token": ["In", "all", "three", "systems", "induction", "was", "carried", "out", "with", "0.5", "mg", "C0015846#ent", "<e1>", "or", "0.05", "mg", "sulfentanil", ",", "followed", "by", "C0015131#ent", "<e2>", "and", "a", "muscle", "relaxant"], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015131", "name": "C0015131#ent", "pos": [20, 21]}}
{"token": ["Agonist-mediated", "receptor", "phosphorylation", "by", "one", "or", "more", "of", "the", "members", "of", "the", "G-protein", "receptor", "kinase", "C0872383#ent", "<e1>", ")", "family", "is", "an", "established", "model", "for", "G-protein-coupled", "receptor", "C1428424#ent", "<e2>", ")", "phosphorylation", "resulting", "in", "receptor", "desensitization"], "h": {"id": "C0872383", "name": "C0872383#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1428424", "name": "C1428424#ent", "pos": [26, 27]}}
{"token": ["These", "results", "demonstrate", "that", "loss", "of", "C0872383#ent", "<e1>", "function", "can", "lead", "to", "reduced", "C1428424#ent", "<e2>", "signal", "transduction", "and", "suggest", "an", "important", "role", "for", "RGS", "proteins", "the", "regulation", "of", "chemosensation", "."], "h": {"id": "C0872383", "name": "C0872383#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1428424", "name": "C1428424#ent", "pos": [13, 14]}}
{"token": ["Mutant", "strains", "were", "less", "virulent", "than", "the", "C1883559#ent", "<e1>", "almost", "every", "location", "examined", "for", "C0333519#ent", "<e2>", "on", "tooth", "surfaces", "level", "of", "involvement", "of", "lesions", "(", "depth", "and", "severity", ")", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0333519", "name": "C0333519#ent", "pos": [14, 15]}}
{"token": ["C1417490#ent", "<e1>", "on", "chromosome", "1q21", "localized", "in", "two", "Cypriot", "families", ",", "and", "C0268113#ent", "<e2>", "on", "chromosome", "16p12", "was", "localized", "in", "a", "single", "Italian", "family"], "h": {"id": "C1417490", "name": "C1417490#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268113", "name": "C0268113#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "sildenafil", "potentiates", "NO-mediated", "inhibition", "of", "platelet", "aggregation", "blockade", "of", "cGMP", "metabolism", "and", "that", "C2987167#ent", "<e1>", "inhibitors", "may", "have", "important", "C0085826#ent", "<e2>", "to", "the", "prevention", "of", "cardiovascular", "disease"], "h": {"id": "C2987167", "name": "C2987167#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085826", "name": "C0085826#ent", "pos": [22, 23]}}
{"token": ["Wis1", "and", "C1539816#ent", "<e1>", "also", "turned", "out", "to", "down-regulate", "C1420306#ent", "<e2>", "+", "gene", "at", "the", "stationary", "phase"], "h": {"id": "C1539816", "name": "C1539816#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [9, 10]}}
{"token": ["Four", "of", "31", "Crohn's", "disease", "tissues", "and", "none", "of", "the", "30", "control", "and", "C0009324#ent", "<e1>", "tissues", "amplified", "C0030524#ent", "<e2>", "DNA", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030524", "name": "C0030524#ent", "pos": [17, 18]}}
{"token": ["The", "present", "experiments", "tested", "whether", "the", "time", "course", "the", "effect", "of", "C0006462#ent", "<e1>", "on", "rhythmical", "slow", "activity", "differed", "from", "that", "of", "the", "C0008188#ent", "<e2>"], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [22, 23]}}
{"token": ["The", "relative", "potency", "of", "C0006462#ent", "<e1>", "was", "substantially", "greater", "than", "that", "of", "C0008188#ent", "<e2>", "."], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [12, 13]}}
{"token": ["We", "identified", "the", "gene", "responsible", "for", "these", "phenotypes", "as", "SUPPRESSOR", "OF", "drm1", "drm2", "cmt3", "(", "C1419891#ent", "<e1>", ")", ",", "which", "encodes", "an", "C1422076#ent", "<e2>", "possesses", "seven", "promoter", "tandem", "repeats"], "h": {"id": "C1419891", "name": "C1419891#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1422076", "name": "C1422076#ent", "pos": [22, 23]}}
{"token": ["By", "comparing", "the", "distribution", "in", "the", "cell", "of", "C0035542#ent", "<e1>", "the", "bonafide", "intracellular", "C0005220#ent", "<e2>", ",", "and", "the", "periplasmic", "alkaline", "phosphatase", "enzymes", ",", "we", "showed", "that", "C0035542#ent", "<e1>", "an", "intracellular", "enzyme", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [13, 14]}}
{"token": ["IL-6", "deficiency", "abrogated", "satellite", "cell", "proliferation", "myonuclear", "accretion", "in", "the", "preexisting", "myofiber", "by", "impairing", "C1367307#ent", "<e1>", "activation", "and", "expression", "of", "its", "target", "C1413172#ent", "<e2>"], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413172", "name": "C1413172#ent", "pos": [22, 23]}}
{"token": ["Two", "inhibitors", "of", "tyrosine", "kinase", "herbimycin", "A", "1.75", "&", "C1706475#ent", "<e1>", ")", "and", "genistein", "(", "100", "&", "C1706475#ent", "<e1>", ")", ",", "had", "no", "effect", "on", "PRL-induced", "activation", "of", "C3539645#ent", "<e1>", "."], "h": {"id": "C1706475", "name": "C1706475#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [28, 29]}}
{"token": ["In", "five", "patients", "with", "C3890941#ent", "<e1>", "clinical", "myokymia", "increased", "and", "C0684219#ent", "<e2>", "burst", "amplification", "occurred", "when", "ionized", "Ca++", "was", "lowered", "by", "hyperventilation", "."], "h": {"id": "C3890941", "name": "C3890941#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0684219", "name": "C0684219#ent", "pos": [10, 11]}}
{"token": ["C0151313#ent", "<e1>", "a", "prominent", "component", "of", "C0011882#ent", "<e2>"], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011882", "name": "C0011882#ent", "pos": [6, 7]}}
{"token": ["In", "this", "patient", "the", "C0023290#ent", "<e1>", "finally", "cured", "with", "C0025179#ent", "<e2>", "followed", "by", "pentacarinat", "isothianate", "as", "maintenance", "therapy", "conjunction", "with", "highly", "active", "antiretroviral", "treatment"], "h": {"id": "C0023290", "name": "C0023290#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0025179", "name": "C0025179#ent", "pos": [9, 10]}}
{"token": ["The", "patient", "was", "included", "in", "a", "secondary", "prophylaxis", "protocol", "for", "C0023290#ent", "<e1>", "a", "monthly", "dose", "of", "Glucantime", "(", "C0025179#ent", "<e2>", "for", "life", "."], "h": {"id": "C0023290", "name": "C0023290#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0025179", "name": "C0025179#ent", "pos": [18, 19]}}
{"token": ["The", "present", "study", "aimed", "to", "evaluate", "the", "renal", "and", "hepatic", "responses", "eight", "dogs", "with", "C0023290#ent", "<e1>", "to", "treatment", "with", "C0025179#ent", "<e2>", "to", "verify", "the", "occurrence", "of", "possible", "side", "effects"], "h": {"id": "C0023290", "name": "C0023290#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0025179", "name": "C0025179#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "C1506818#ent", "<e1>", "might", "promote", "cell", "death", "the", "absence", "of", "C1704461#ent", "<e2>", "."], "h": {"id": "C1506818", "name": "C1506818#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704461", "name": "C1704461#ent", "pos": [11, 12]}}
{"token": ["The", "restriction", "fragment", "generated", "were", "used", "to", "track", "the", "inheritance", "of", "C1366370#ent", "<e1>", "alleles", "within", "families", "allowing", "C0019069#ent", "<e2>", "carrier", "status", "to", "be", "determined", "in", "individuals", "at", "risk", "."], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [17, 18]}}
{"token": ["The", "C1366370#ent", "<e1>", "to", "a", "C0019069#ent", "<e2>", "phenotype", "with", "factor", "VIII", "function", "discordance", "between", "one-stage", "clotting", "and", "chromogenic", "two-stage", "assays", "."], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [1, 2]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [5, 6]}}
{"token": ["A", "pre-trans-splicing", "molecule", "(", "PTM", ")", "corrected", "endogenous", "C1366370#ent", "<e1>", "mRNA", "in", "F8", "knockout", "mice", "the", "C0019069#ent", "<e2>", "phenotype", ",", "producing", "sufficient", "functional", "C1366370#ent", "<e1>", "to", "correct", "the", "C0019069#ent", "<e2>", "phenotype", "."], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "the", "role", "of", "C0031670#ent", "<e1>", "PLD", ")", "and", "its", "product", "phosphatidic", "acid", "PA", ")", "in", "C1417574#ent", "<e2>", "cultured", "L6", "rat", "skeletal", "myoblasts"], "h": {"id": "C0031670", "name": "C0031670#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "C0038880#ent", "<e1>", "induces", "mitogenic", "activity", "several", "cell", "lines", "the", "pathway", "from", "C1709402#ent", "<e2>", "MEK", "and", "ERK", "."], "h": {"id": "C0038880", "name": "C0038880#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [15, 16]}}
{"token": ["Although", "a", "low", "amount", "of", "C1705329#ent", "<e1>", "is", "expressed", "ubiquitously", "in", "all", "cell", "types", "the", "absence", "of", "IFNs", ",", "C1705329#ent", "<e1>", "expression", "is", "induced", "at", "transcriptional", "level", "C1415900#ent", "<e1>", "."], "h": {"id": "C1705329", "name": "C1705329#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [27, 28]}}
{"token": ["RNase", "H", "to", "a", "C0028632#ent", "<e1>", "which", "includes", "transposase", ",", "retroviral", "integrase", "Holliday", "junction", "resolvase", "and", "RISC", "nuclease", "C1414332#ent", "<e2>", "."], "h": {"id": "C0028632", "name": "C0028632#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414332", "name": "C1414332#ent", "pos": [18, 19]}}
{"token": ["C0910750#ent", "<e1>", "is", "a", "recent", "C0304361#ent", "<e2>", "fungicide", "widely", "used", "in", "viticulture", "and", "in", "Integrated", "Pest", "Management", "."], "h": {"id": "C0910750", "name": "C0910750#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304361", "name": "C0304361#ent", "pos": [5, 6]}}
{"token": ["Adhesion", "of", "RON-expressing", "epithelial", "cells", "to", "ECM", "caused", "phosphorylation", "of", "C0084370#ent", "<e1>", ",", "which", "depended", "on", "the", "kinase", "activity", "both", "C0084370#ent", "<e1>", "itself", "and", "C0080298#ent", "<e1>", "."], "h": {"id": "C0084370", "name": "C0084370#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [24, 25]}}
{"token": ["In", "many", "situations", ",", "the", "neurologists", "may", "function", "as", "a", "consultant", "and", "principal", "physician", "for", "patients", "with", "primary", "nervous", "system", "disorders", "Parkinson's", "disease", "C0026769#ent", "<e1>", "Alzheimer's", "disease", "epilepsy", ",", "migraine", ",", "cerebrovascular", "disease", "movement", "disorders", "and", "C0027868#ent", "<e2>"], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [23, 24]}, "relation": "related_to", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [36, 37]}}
{"token": ["In", "this", "paper", ",", "we", "review", "the", "potential", "of", "C1706243#ent", "<e1>", "as", "a", "drug", "target", "oxidized", "C2348308#ent", "<e2>", "as", "a", "new", "class", "of", "ligand", "for", "C1706243#ent", "<e1>", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706243", "name": "C1706243#ent", "pos": [9, 10]}}
{"token": ["The", "response", "was", "positively", "related", "to", "C2348308#ent", "<e1>", "concentration", "and", "suggests", "that", "C2348308#ent", "<e1>", "may", "bind", "to", "and", "activate", "porcine", "C1706243#ent", "<e1>", ",", "leading", "to", "increased", "expression", "of", "aP2", "and", "adiponectin", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706243", "name": "C1706243#ent", "pos": [20, 21]}}
{"token": ["Increased", "aortic", "pressure", "dogs", "without", "C0151814#ent", "<e1>", "reversible", "decreases", "in", "end-diastolic", "wall", "thickness", ",", "C1705456#ent", "<e2>", "and", "LV", "dP/dt"], "h": {"id": "C0151814", "name": "C0151814#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705456", "name": "C1705456#ent", "pos": [14, 15]}}
{"token": ["The", "causative", "molecules", "C0020757#ent", "<e1>", "subtypes", "include", "ABCA12", ",", "C0023837#ent", "<e2>", ",", "12R-lipoxygenase", ",", "CYP4F2", "homolog", ",", "ichthyin", "and", "steroid", "sulphatase", "all", "these", "are", "thought", "to", "be", "related", "to", "the", "intercellular", "lipid", "layers"], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [9, 10]}}
{"token": ["Tachypacing", "of", "C4084734#ent", "<e1>", "cardiomyocytes", "induced", "a", "gradual", "and", "significant", "degradation", "of", "C2931187#ent", "<e2>", "but", "not", "actin", ",", "and", "caused", "contractile", "dysfunction"], "h": {"id": "C4084734", "name": "C4084734#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2931187", "name": "C2931187#ent", "pos": [12, 13]}}
{"token": ["The", "proteolytic", "cleavage", "C1366565#ent", "<e1>", "by", "all", "three", "C0007428#ent", "<e2>", "resulted", "in", "the", "loss", "of", "the", "active", "site", "C1366565#ent", "<e1>", "and", "the", "inactivation", "of", "C1366565#ent", "<e1>", "anti-neutrophil", "elastase", "capacity", "."], "h": {"id": "C1366565", "name": "C1366565#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [8, 9]}}
{"token": ["Although", "having", "only", "a", "single", "cysteine-rich", "zinc", "finger", "region", "compared", "to", "two", "for", "C1259877#ent", "<e1>", "n-chimaerin", "thus", "closely", "resembled", "C1335261#ent", "<e2>"], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335261", "name": "C1335261#ent", "pos": [19, 20]}}
{"token": ["Of", "the", "C1259877#ent", "<e1>", "isoenzymes", ",", "the", "levels", "of", "C1335261#ent", "<e2>", "increased", "in", "the", "membrane", "fraction", "3", "days", "of", "exposure", "to", "glucose", ",", "and", "protein", "kinase", "C", "zeta", "increased", "after", "5", "days", "of", "exposure", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335261", "name": "C1335261#ent", "pos": [9, 10]}}
{"token": ["Ion-exchange", "Fast", "Protein", "Liquid", "Chromatography", "FPLC", ")", "on", "C0021345#ent", "<e1>", "Mono", "S", "optimized", "for", "the", "analytical", "separation", "C0051169#ent", "<e2>", "rat", "liver", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [17, 18]}}
{"token": ["Positive", "transcription", "elongation", "factor", "b", "(", "P-TEFb", ")", "comprises", "a", "cyclin", "(", "T1", "or", "T2", ")", "and", "a", "kinase", ",", "cyclin-dependent", "kinase", "9", "C1172090#ent", "<e1>", ")", ",", "which", "phosphorylates", "the", "C1416810#ent", "<e2>", "RNA", "polymerase", "II"], "h": {"id": "C1172090", "name": "C1172090#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1416810", "name": "C1416810#ent", "pos": [30, 31]}}
{"token": ["Structures", "of", "G-quadruplex", "C0011519#ent", "<e1>", "can", "be", "typically", "stabilized", "by", "monovalent", "cations", "as", "C0071766#ent", "<e2>", "Na(+", ")", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0071766", "name": "C0071766#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "compare", "the", "cutaneous", "postischaemic", "hyperaemic", "response", "in", "young", "C0011860#ent", "<e1>", "patients", "and", "healthy", "subjects", "normoglycaemia", ",", "C1864904#ent", "<e2>", "in", "the", "posthypoglycaemic", "state"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1864904", "name": "C1864904#ent", "pos": [24, 25]}}
{"token": ["Significant", "upregulation", "of", "C1706544#ent", "<e1>", "occurred", "in", "vitro", "in", "vivo", "AECs", "after", "C2697656#ent", "<e2>", "stimulation", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [12, 13]}}
{"token": ["Clindamycin", ",", "metronidazole", "and", "polymyxin", "B", "the", "C1706544#ent", "<e1>", "expression", "when", "endothelium", "was", "stimulated", "with", "B.", "fragilis", "C2697656#ent", "<e2>", "and", "augmented", "C1706544#ent", "<e1>", "expression", "by", "Tox", "1", "Tox", "2"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [17, 18]}}
{"token": ["C1706544#ent", "<e1>", "was", "intensely", "stained", "on", "megakaryocytes", "in", "C2697656#ent", "<e2>", "treated", "rats", ",", "as", "detected", "by", "flow", "cytometric", "analysis"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}}
{"token": ["Interestingly", ",", "both", "C0235480#ent", "<e1>", "and", "C0028928#ent", "<e2>", "separately", "to", "human", "platelets", "induced", "protein-tyrosine", "phosphorylation", "but", "C0028928#ent", "<e2>", "not", "cause", "any", "inhibition", "of", "PAF-induced", "protein-tyrosine", "phosphorylation.(ABSTRACT", "TRUNCATED", "AT", "400", "WORDS", ")"], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [6, 7]}}
{"token": ["The", "C1412028#ent", "<e1>", "a", "superfamily", "of", "structurally", "and", "functionally", "closely", "related", "C3540790#ent", "<e2>", ",", "one", "of", "those", "functions", "being", "reversible", "inhibition", "by", "catechol", "derivatives", "."], "h": {"id": "C1412028", "name": "C1412028#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["Catechol-O-methyltransferase", "(", "COMT", ")", "plays", "an", "important", "role", "in", "C1825684#ent", "<e1>", "COMT", "inactivates", "catechol", "estrogens", "have", "C0029016#ent", "<e2>"], "h": {"id": "C1825684", "name": "C1825684#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [16, 17]}}
{"token": ["The", "positive", "inotropic", "effects", "a", "jugular", "vein", "infusion", "of", "either", "C0282210#ent", "<e1>", "or", "epinephrine", "were", "attenuated", "by", "phenylisopropyladenosine", ",", "an", "C1412245#ent", "<e2>", "agonist", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412245", "name": "C1412245#ent", "pos": [20, 21]}}
{"token": ["In", "the", "human", "and", "rat", "C0242965#ent", "<e1>", ",", "the", "B29", "gene", "located", "between", "the", "skeletal", "muscle-specific", "Na-channel", "alpha", "subunit", "C1419862#ent", "<e2>", ")", "gene", "and", "the", "pituitary-specific", "growth", "hormone", "GH-N", ")", "gene", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419862", "name": "C1419862#ent", "pos": [19, 20]}}
{"token": ["Novel", "C0991617#ent", "<e1>", "include", "the", "COX-inhibiting", "nitric", "oxide", "donors", "and", "the", "C0023837#ent", "<e2>", "(LOX)/COX", "inhibitor", "licofelone", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [11, 12]}}
{"token": ["Psychological", "evaluation", "a", "valid", "psychological", "adjustment", "almost", "all", "cases", ",", "despite", "the", "majority", "of", "workers", "reporting", "some", "C2364135#ent", "<e1>", "mainly", "to", "the", "particularly", "C0018520#ent", "<e2>", "a", "micro-climate", "with", "a", "high", "rate", "of", "humidity", "."], "h": {"id": "C2364135", "name": "C2364135#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0018520", "name": "C0018520#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "skeletrophin", "is", "a", "novel", "ubiquitin", "ligase", "targets", "the", "intracellular", "region", "Jagged-2", "and", "is", "aberrantly", "C3889446#ent", "<e1>", "in", "multiple", "myeloma", "cells", "possibly", "activating", "C2827371#ent", "<e2>", "on", "stromal", "cells", "ligand-dependent", "Notch", "signaling"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2827371", "name": "C2827371#ent", "pos": [24, 25]}}
{"token": ["With", "age", ",", "clinical", "evolution", "C3463992#ent", "<e1>", "to", "the", "C0037769#ent", "<e2>", "observed", "in", "as", "many", "as", "10", "cases", ",", "among", "which", "two", "cases", "showed", "further", "transition", "to", "the", "Lennox-Gastaut", "syndrome"], "h": {"id": "C3463992", "name": "C3463992#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037769", "name": "C0037769#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "central", "administration", "an", "alpha-adrenergic", "receptor", "antagonist", "C0031441#ent", "<e1>", ",", "or", "a", "beta-adrenergic", "receptor", "antagonist", "sotalol", ",", "only", "attenuated", "the", "C0015967#ent", "<e2>", "Db-cAMP", "while", "a", "cholinergic", "muscarinic", "receptor", "antagonist", "atropine", ",", "specifically", "antagonized", "Db-cGMP-induced", "hyperthermia", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [22, 23]}}
{"token": ["However", ",", "C0287041#ent", "<e1>", "but", "not", "MPG", "activated", "C0669365#ent", "<e2>", "eNOS", ")", "as", "assessed", "by", "phosphorylation", "of", "eNOS", "on", "Ser1177", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}}
{"token": ["Using", "a", "cell", "proliferation", "assay", "a", "small", "interfering", "approach", ",", "we", "show", "that", "C0812267#ent", "<e1>", "expression", "is", "required", "for", "the", "C1335278#ent", "<e2>", "action", "of", "estrogen", "in", "the", "T47D", "breast", "cancer", "cell", "line", "."], "h": {"id": "C0812267", "name": "C0812267#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335278", "name": "C1335278#ent", "pos": [20, 21]}}
{"token": ["Different", "combinations", "of", "these", "C0017337#ent", "<e1>", "result", "in", "a", "spectrum", "of", "C0039730#ent", "<e2>", "in", "severity", "from", "asymptomatic", "to", "intrauterine", "death"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039730", "name": "C0039730#ent", "pos": [11, 12]}}
{"token": ["This", "outbreak", "led", "to", "the", "first", "description", "of", "C0243025#ent", "<e1>", "HPS", ")", ",", "a", "rodentborne", "C0042769#ent", "<e2>"], "h": {"id": "C0243025", "name": "C0243025#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [15, 16]}}
{"token": ["C0243025#ent", "<e1>", "HPS", ")", "is", "a", "rodentborne", "C0042769#ent", "<e2>", "by", "severe", "pulmonary", "illness", "and", "a", "case-fatality", "ratio", "of", "43", "%", "."], "h": {"id": "C0243025", "name": "C0243025#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["Polymerase", "chain", "reaction", "PCR", ")", "methodology", "and", "cDNA", "library", "screening", "were", "used", "to", "C1875400#ent", "<e1>", "a", "cDNA", "clone", "encoding", "a", "cGMP-binding", ",", "cGMP-specific", "phosphodiesterase", "C2987167#ent", "<e2>", ")", "from", "bovine", "lung"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2987167", "name": "C2987167#ent", "pos": [24, 25]}}
{"token": ["The", "percentage", "of", "patients", "with", "fungal", "cultures", "negative", "for", "Candida", "albicans", "statistically", "significantly", "for", "C0054259#ent", "<e1>", "than", "for", "C0009074#ent", "<e2>", "(", "92", "vs.", "74", ",", "P", "=", ".003", ")", "at", "the", "eight-day", "posttreatment", "examination", "."], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009074", "name": "C0009074#ent", "pos": [18, 19]}}
{"token": ["To", "clarify", "the", "role", "of", "C1705267#ent", "<e1>", "in", "hereditary", "nonpolyposis", "colorectal", "cancer", "C1705266#ent", "<e2>", ")", ",", "we", "searched", "for", "C1705267#ent", "<e1>", "somatic", "and", "germline", "mutations", "particularly", "in", "the", "repeat", "regions", "in", "41", "C1705266#ent", "<e2>", "patient", "cells"], "h": {"id": "C1705267", "name": "C1705267#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705266", "name": "C1705266#ent", "pos": [12, 13]}}
{"token": ["C1413633#ent", "<e1>", "delivers", "copper", "to", "mitochondria", "to", "C1537985#ent", "<e2>", "the", "chaperones", "Cox11", ",", "Sco1", ",", "and", "Sco2", "."], "h": {"id": "C1413633", "name": "C1413633#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "a", "C57Y", "mutant", "of", "C1413633#ent", "<e1>", "fails", "to", "transfer", "copper", "C1537985#ent", "<e2>", "but", "is", "competent", "for", "copper", "transfer", "Cox11", "."], "h": {"id": "C1413633", "name": "C1413633#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1537985", "name": "C1537985#ent", "pos": [13, 14]}}
{"token": ["C0121300#ent", "<e1>", "with", "and", "without", "C0055461#ent", "<e2>", "was", "administered", "to", "chick", "embryos", "mice", ",", "and", "rats", "."], "h": {"id": "C0121300", "name": "C0121300#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [5, 6]}}
{"token": ["We", "show", "the", "presence", "of", "C0813143#ent", "<e1>", "and", "GFRalpha-1", ",", "GFRalpha-2", ",", "and", "C1708413#ent", "<e2>", "in", "chicken", "motoneurons", "in", "situ", "hybridization", "reverse", "transcription-PCR", "techniques", "."], "h": {"id": "C0813143", "name": "C0813143#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1708413", "name": "C1708413#ent", "pos": [13, 14]}}
{"token": ["Cultured", "fibroblasts", "showed", "defective", "incorporation", "of", "both", "C2939773#ent", "<e1>", "and", "[14C]propionate", "into", "protein", "by", "whole", "cells", "a", "decrease", "of", "C0039676#ent", "<e2>", "activity", "in", "cell", "extracts"], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039676", "name": "C0039676#ent", "pos": [19, 20]}}
{"token": ["This", "is", "effected", "by", "the", "demethylation", "of", "trapped", "C2939773#ent", "<e1>", ",", "catalysed", "by", "a", "vitamin", "B12", "C0039676#ent", "<e2>"], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039676", "name": "C0039676#ent", "pos": [16, 17]}}
{"token": ["Both", "the", "spectrophotometric", "and", "the", "radiometric", "methods", "based", "on", "the", "conversion", "of", "C2939773#ent", "<e1>", "to", "tetrahydrofolate", "by", "C0039676#ent", "<e2>"], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039676", "name": "C0039676#ent", "pos": [17, 18]}}
{"token": ["The", "region", "contains", "four", "closely", "spaced", "cistrons", "(", "bphKHJI", ")", "encoding", "a", "C0017837#ent", "<e1>", "GST", ")", ",", "a", "2-hydroxypenta-2,4-dienoate", "hydratase", "an", "C1412333#ent", "<e2>", "acylating", ")", "and", "a", "4-hydroxy-2-oxovalerate", "aldolase", "respectively", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412333", "name": "C1412333#ent", "pos": [21, 22]}}
{"token": ["The", "overexpression", "of", "dominant", "negative", "mutants", "of", "C0079471#ent", "<e1>", "or", "ERK2", "proteins", "depressed", "ChAT", "promoter", "activation", "C0084839#ent", "<e2>", "in", "transient", "transfection", "assays"], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0084839", "name": "C0084839#ent", "pos": [16, 17]}}
{"token": ["Bile", "acids", "C3889135#ent", "<e1>", "repressed", "endogenous", "CYP7A1", "but", "stimulated", "alpha-fetoprotein", "transcription", "factor", "C1417839#ent", "<e2>", ")", "and", "small", "heterodimer", "partner", "SHP", ")", "mRNA", "expression", "in", "HepG2", "cells"], "h": {"id": "C3889135", "name": "C3889135#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417839", "name": "C1417839#ent", "pos": [12, 13]}}
{"token": ["Clofibryl", "and", "fenofibryl", "acyl", "(", "ester", ")", "glucuronides", "(", "CAG", "and", "C1707999#ent", "<e1>", ")", "are", "major", "metabolites", "in", "humans", "of", "the", "hypolipidaemic", "drugs", "C0009002#ent", "<e2>", "and", "fenofibrate", ",", "respectively", "."], "h": {"id": "C1707999", "name": "C1707999#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [23, 24]}}
{"token": ["One", "of", "the", "probands", "had", "a", "novel", "frameshift", "mutation", "Phe75fsdelT", ")", "in", "exon", "2", "the", "HNF-4alpha", "gene", ",", "resulting", "in", "a", "premature", "termination", "translation", "after", "117", "C3539946#ent", "<e1>", "the", "messenger", "RNA", "by", "that", "C0002085#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [33, 34]}}
{"token": ["This", "study", "tested", "the", "hypotheses", "that", "the", "C1413968#ent", "<e1>", "bound", "actin", "and", "that", "the", "interaction", "could", "be", "disrupted", "by", "C3850168#ent", "<e2>", "NSAIDs", "."], "h": {"id": "C1413968", "name": "C1413968#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3850168", "name": "C3850168#ent", "pos": [19, 20]}}
{"token": ["Supplemental", "administration", "of", "C0546865#ent", "<e1>", "therefore", "effective", "for", "the", "improvement", "of", "C0028734#ent", "<e2>", "and", "QOL", "in", "BPH", "patients", "resistant", "to", "an", "alpha1-adrenoceptor", "blocker"], "h": {"id": "C0546865", "name": "C0546865#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0028734", "name": "C0028734#ent", "pos": [11, 12]}}
{"token": ["We", "examined", "the", "effectiveness", "of", "supplemental", "administration", "C0546865#ent", "<e1>", "patients", "with", "benign", "prostatic", "hyperplasia", "BPH", ")", "whose", "C0028734#ent", "<e2>", "was", "not", "adequately", "relieved", "by", "an", "alpha1-adrenoceptor", "blocker"], "h": {"id": "C0546865", "name": "C0546865#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0028734", "name": "C0028734#ent", "pos": [17, 18]}}
{"token": ["Hereditary", "multiple", "exostoses", "C1417201#ent", "<e1>", ")", "is", "an", "autosomal", "dominant", "C0263661#ent", "<e2>", "a", "wide", "spectrum", "of", "clinical", "manifestations"], "h": {"id": "C1417201", "name": "C1417201#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "a", "patient", "with", "CREST", "syndrome", "calcinosis", ",", "C0151445#ent", "<e1>", "phenomenon", ",", "esophageal", "dysfunction", "sclerodactyly", ",", "and", "telangiectasia", ")", "who", "paradoxically", "experienced", "worsening", "of", "C0151445#ent", "<e1>", "phenomenon", "when", "using", "C0724441#ent", "<e1>", "for", "ED", "."], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [30, 31]}}
{"token": ["The", "NADPH-dependent", "formation", "of", "AFB1", "C0001962#ent", "<e1>", "by", "recombinant", "human", "C1412329#ent", "<e2>", "was", "confirmed", "by", "liquid", "chromatography", "to", "electrospray", "ionization", "mass", "spectrometry"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412329", "name": "C1412329#ent", "pos": [10, 11]}}
{"token": ["Previously", ",", "we", "reported", "that", "C1335812#ent", "<e1>", "is", "a", "C0062776#ent", "<e2>", "HMTase", ")", "."], "h": {"id": "C1335812", "name": "C1335812#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0062776", "name": "C0062776#ent", "pos": [9, 10]}}
{"token": ["ESET", "(", "C1335812#ent", "<e1>", "a", "SET", "domain", "also", "called", "SETDB1", ")", "is", "a", "novel", "C0062776#ent", "<e2>", "catalyzes", "methylation", "of", "histone", "H3-lysine", "9", "H3-K9", ")", "."], "h": {"id": "C1335812", "name": "C1335812#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0062776", "name": "C0062776#ent", "pos": [14, 15]}}
{"token": ["In", "acute", "promyelocytic", "leukemia", "APL", ")", ",", "the", "typical", "t(15;17", ")", "and", "the", "rare", "t(11;17", ")", "translocations", "express", ",", "respectively", ",", "the", "PML/RARalpha", "and", "C1867727#ent", "<e1>", "where", "RARalpha", "is", "C1366536#ent", "<e2>", "."], "h": {"id": "C1867727", "name": "C1867727#ent", "pos": [24, 25]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [29, 30]}}
{"token": ["The", "role", "of", "the", "C0020676#ent", "<e1>", "in", "the", "C1414672#ent", "<e2>", "of", "antiarrhythmic", "activity", "still", "a", "matter", "of", "considerable", "controversy", "among", "investigators", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [8, 9]}}
{"token": ["Sometimes", "acquired", "and", "reversible", ",", "they", "are", "due", "to", "licorice", "intoxication", "C0020676#ent", "<e1>", ",", "chronic", "alcoholism", "may", "be", "involved", "in", "the", "C1414672#ent", "<e2>", "of", "some", "cases", "of", "hypertension", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [21, 22]}}
{"token": ["We", "report", "a", "case", "of", "C0022660#ent", "<e1>", "attributable", "to", "C0024730#ent", "<e2>", "administered", "in", "the", "course", "of", "therapy", "for", "acute", "glaucoma"], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024730", "name": "C0024730#ent", "pos": [9, 10]}}
{"token": ["Candida", "infection", "the", "immunosupressed", "patient", "comprises", "a", "wide", "range", "of", "C0009450#ent", "<e1>", "as", "candidemia", ",", "C0153252#ent", "<e2>", "endocarditis", ",", "meningitis", "and", "endophthalmitis", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0153252", "name": "C0153252#ent", "pos": [15, 16]}}
{"token": ["Immunological", "reactions", "cause", "C0005944#ent", "<e1>", "hyperthyreosis", ",", "exophthalmus", "and", "C0027145#ent", "<e2>", "on", "the", "other", "hand", ",", "C0005944#ent", "<e1>", "impair", "immunological", "defense"], "h": {"id": "C0005944", "name": "C0005944#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027145", "name": "C0027145#ent", "pos": [9, 10]}}
{"token": ["A", "case", "of", "C1862939#ent", "<e1>", "ALS", ")", "diagnosed", "by", "C0037315#ent", "<e2>", "described", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0037315", "name": "C0037315#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "increasing", "actin", "polymerization", "C3181250#ent", "<e1>", "(", "0.5", "microm", ")", "increased", "C3890000#ent", "<e2>", "and", "SM", "alpha-actin", "promoter", "activity", "by", "22-fold", "and", "13-fold", ",", "respectively", "."], "h": {"id": "C3181250", "name": "C3181250#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3890000", "name": "C3890000#ent", "pos": [13, 14]}}
{"token": ["Mutations", "that", "inactivate", "the", "C1417703#ent", "<e1>", "C1417705#ent", "<e2>", ")", "binding", "site", "or", "C1417705#ent", "<e2>", "depletion", "of", "the", "nuclear", "extract", "decrease", "basal", "transcription", "influencing", "receptor-dependent", "induction", "."], "h": {"id": "C1417703", "name": "C1417703#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417705", "name": "C1417705#ent", "pos": [6, 7]}}
{"token": ["Extracellular", "growth-stimulatory", "and", "-inhibitory", "signals", "govern", "the", "C3814378#ent", "<e1>", "activity", "of", "C0080054#ent", "<e2>", "cdks", ")", ",", "which", "in", "turn", "can", "phosphorylate", "the", "retinoblastoma", "gene", "product", "pRb", ",", "to", "cancel", "its", "growth-suppressive", "function", "."], "h": {"id": "C3814378", "name": "C3814378#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [11, 12]}}
{"token": ["HSP60", "is", "encoded", "by", "the", "C1415782#ent", "<e1>", "gene", "located", "on", "2q33", ",", "one", "of", "the", "suggested", "C0002893#ent", "<e2>", "susceptibility", "loci", "the", "French", "Caucasian", "population", "."], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002893", "name": "C0002893#ent", "pos": [16, 17]}}
{"token": ["This", "increase", "was", "also", "found", "when", "the", "C0013227#ent", "<e1>", "was", "given", "to", "animals", "pretreated", "with", "C0030135#ent", "<e2>", "(", "pCPA", ")", "(", "150", "mg/kg", "ip", "daily", "for", "3", "days", ")", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [15, 16]}}
{"token": ["This", "increase", "was", "also", "found", "when", "the", "C0013227#ent", "<e1>", "was", "given", "to", "animals", "pretreated", "with", "parachlorophenylalanine", "(", "C0030135#ent", "<e2>", ")", "(", "150", "mg/kg", "ip", "daily", "for", "3", "days", ")", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "removal", "of", "C0001637#ent", "<e1>", "endings", "facilitated", "C0025598#ent", "<e2>", "relaxant", "effects", "(", "p<0.05", ")", "."], "h": {"id": "C0001637", "name": "C0001637#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [9, 10]}}
{"token": ["The", "presented", "results", "are", "consistent", "with", "expression", "of", "beta4-containing", "(", "i.e.", ",", "beta4", "*", ")", "C1839729#ent", "<e1>", ",", "likely", "alpha3beta4", "*", ",", "in", "pre-synaptic", "terminals", "effect-positive", "C3810553#ent", "<e2>", "neurons", "."], "h": {"id": "C1839729", "name": "C1839729#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3810553", "name": "C3810553#ent", "pos": [26, 27]}}
{"token": ["After", "a", "single", "dosage", "of", "C0001911#ent", "<e1>", "25", "mg/kg", "was", "taken", "orally", "by", "healthy", "volunteers", "C0338437#ent", "<e2>", "patients", ",", "sulfoxide", "and", "sulfone", "were", "found", "in", "blood", "at", "20", "and", "40", "min", "respectively", "."], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0338437", "name": "C0338437#ent", "pos": [15, 16]}}
{"token": ["The", "selective", "stimulation", "of", "C1418624#ent", "<e1>", "Zn2", "+", "corresponded", "to", "a", "binding", "of", "these", "C3539768#ent", "<e2>", "a", "zinc-affinity", "column", ",", "while", "group", "II", "phospholipase", "A2", "not", "bound", "."], "h": {"id": "C1418624", "name": "C1418624#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [14, 15]}}
{"token": ["Pre-", "and", "postoperative", "serum", "samples", "of", "patients", "undergoing", "splenectomy", "were", "studied", "for", "C1418624#ent", "<e1>", "group", "II", "phospholipase", "A2", "and", "C-reactive", "protein", "mass", "concentrations", "and", "catalytic", "activity", "concentration", "of", "C3539768#ent", "<e2>"], "h": {"id": "C1418624", "name": "C1418624#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [28, 29]}}
{"token": ["In", "a", "cohort", "of", "multiple", "sclerosis", "C0026769#ent", "<e1>", ")", "patients", "ketanserin", ",", "a", "selective", "C2936522#ent", "<e2>", "induces", "recurrent", "yawning", "particularly", "when", "administered", "in", "daytime", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936522", "name": "C2936522#ent", "pos": [14, 15]}}
{"token": ["Sometimes", "the", "joint", "noise", "immediately", "precede", "C0231528#ent", "<e1>", "fluctuate", "with", "the", "C0030193#ent", "<e2>"], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [11, 12]}}
{"token": ["Castanopsis", "C1427020#ent", "<e1>", "exhibited", "a", "much", "more", "potent", "inhibitory", "activity", "on", "C0121925#ent", "<e2>", "IC(50", ")", "=", "1.6", "microM", ")", "than", "kiwi", "fruit", "C1427020#ent", "<e1>", "(", "IC(50", ")", ">", "or", "=", "27", "microM", ")", "."], "h": {"id": "C1427020", "name": "C1427020#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0121925", "name": "C0121925#ent", "pos": [11, 12]}}
{"token": ["Hypothalamo-hypophyseal-gonadal", "system", "studied", "in", "39", "females", "suffering", "from", "bronchial", "asthma", "and", "in", "47", "C0282556#ent", "<e1>", "females", "suffering", "from", "bronchial", "asthma", "and", "in", "47", "C0282556#ent", "<e1>", "females", "with", "C0020538#ent", "<e1>"], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", ",", "the", "spontaneous", "discharge", "frequency", "of", "C0848337#ent", "<e1>", "neuron", "(", "GDIN", ")", "was", "mainly", "excited", "by", "C1417190#ent", "<e2>", ",", "but", "inhibited", "by", "GM-109", "."], "h": {"id": "C0848337", "name": "C0848337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417190", "name": "C1417190#ent", "pos": [18, 19]}}
{"token": ["Similarly", ",", "CS", "alone", "and", "CS", "plus", "C1705766#ent", "<e1>", "treatment", "also", "prevented", "the", "development", "of", "cartilage", "damage", "associated", "with", "C0003864#ent", "<e2>", "."], "h": {"id": "C1705766", "name": "C1705766#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [19, 20]}}
{"token": ["The", "authors", "recommend", "treatment", "with", "C0072970#ent", "<e1>", "alone", "or", "C0070426#ent", "<e2>", "plus", "indapamide", "regardless", "of", "blood", "pressure", "provided", "there", "is", "no", "contraindication", "."], "h": {"id": "C0072970", "name": "C0072970#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0070426", "name": "C0070426#ent", "pos": [9, 10]}}
{"token": ["However", ",", "the", "C0003015#ent", "<e1>", "letrozole", "and", "C0290883#ent", "<e2>", ",", "and", "the", "steroidal", "inhibitor", "exemestane", ",", "all", "cause", ">", "95", "%", "inhibition", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0290883", "name": "C0290883#ent", "pos": [7, 8]}}
{"token": ["SGS1", "encodes", "a", "C1333949#ent", "<e1>", "with", "similar", "properties", "to", "C1701412#ent", "<e2>"], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1701412", "name": "C1701412#ent", "pos": [9, 10]}}
{"token": ["We", "conclude", "that", "it", "is", "the", "calcium", "chelating", "action", "C1171556#ent", "<e1>", "than", "its", "C0018834#ent", "<e2>", "that", "is", "responsible", "for", "bronchoconstriction", "in", "BG", "dogs", "with", "hyperreactive", "airways", "."], "h": {"id": "C1171556", "name": "C1171556#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018834", "name": "C0018834#ent", "pos": [13, 14]}}
{"token": ["According", "to", "the", "results", "of", "these", "studies", "it", "appears", "that", "the", "recommended", "standard", "dosis", "of", "C0034665#ent", "<e1>", "for", "treatment", "of", "C0013295#ent", "<e2>", "be", "reduced", "by", "one", "half", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [15, 16]}, "relation": "may_prevent", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [20, 21]}}
{"token": ["It", "was", "found", "that", "therapeutic", "doses", "C0034665#ent", "<e1>", "in", "patients", "with", "gastric", "and", "C0013295#ent", "<e2>", "not", "affect", "the", "relevant", "coagulation", "parameters", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [6, 7]}, "relation": "may_prevent", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "C0812246#ent", "<e1>", ",", "via", "NF-kappaB", ",", "and", "JNK", "induces", "C3538735#ent", "<e2>", "and", "EMMPRIN", "in", "macrophage", "to", "tumor", "cell", "cocultures", "and", "this", "leads", "to", "increased", "invasive", "capacity", "of", "the", "tumor", "cells"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538735", "name": "C3538735#ent", "pos": [12, 13]}}
{"token": ["The", "latter", "would", "control", "C0041948#ent", "<e1>", "by", "rapid", "lysis", "of", "C3815527#ent", "<e2>", "hepatocytes", "."], "h": {"id": "C0041948", "name": "C0041948#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3815527", "name": "C3815527#ent", "pos": [10, 11]}}
{"token": ["Since", "TPA", "induces", "differentiation", "in", "human", "breast", "cancer", "cells", "up-regulates", "MnSOD", "gene", "HeLa", "cells", "C1743497#ent", "<e1>", "expression", "and", "AP-1", "and", "C2986464#ent", "<e2>", "measured", "under", "TPA", "treatment", "."], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [20, 21]}}
{"token": ["Since", "TPA", "induces", "differentiation", "in", "human", "breast", "cancer", "cells", "up-regulates", "C1743497#ent", "<e1>", "HeLa", "cells", "MnSOD", "expression", "and", "AP-1", "and", "C2986464#ent", "<e2>", "measured", "under", "TPA", "treatment", "."], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [19, 20]}}
{"token": ["To", "describe", "the", "phenotypic", "spectrum", "of", "dysferlin", "(", "DYSF", ")", "C0678941#ent", "<e1>", "which", "cause", "dysferlinopathies", ",", "autosomal", "recessive", "muscular", "dystrophies", "in", "patients", "with", "a", "C0033626#ent", "<e2>"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033626", "name": "C0033626#ent", "pos": [24, 25]}}
{"token": ["Furthermore", ",", "purified", "cytidylyltransferase", "preincubated", "with", "alkaline", "phosphatase", "a", "substrate", "for", "C4082284#ent", "<e1>", ",", "a", "member", "of", "the", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e2>", "of", "the", "growth", "factor", "receptors", "in", "vitro"], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}}
{"token": ["In", "this", "study", "the", "rapid", "and", "transient", "phosphorylation", "of", "an", "C4082284#ent", "<e1>", "mitogen-activated", "protein", "(", "MAP", ")", "C0031727#ent", "<e2>", "in", "response", "to", "LPS", "from", "B.", "cepacia", "(", "LPS(B.cep", ".", ")", ")"], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [10, 11]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["Cells", "containing", "different", "combinations", "of", "theses", "C3541394#ent", "<e1>", "grow", "at", "different", "rates", "in", "media", "in", "which", "C0003993#ent", "<e2>", "or", "D-asparagine", "is", "the", "only", "source", "of", "nitrogen", "for", "cell", "replication"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003993", "name": "C0003993#ent", "pos": [16, 17]}}
{"token": ["After", "that", "serum", "albumin", "other", "species", ",", "penicillin", "G-acylase", "antibodies", ",", "C1333524#ent", "<e1>", "streptavidin", "were", "newly", "introduced", "as", "the", "chiral", "selectors", "in", "C3813609#ent", "<e2>", "."], "h": {"id": "C1333524", "name": "C1333524#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3813609", "name": "C3813609#ent", "pos": [22, 23]}}
{"token": ["Adsorption", "of", "C1423814#ent", "<e1>", "on", "clay", "surface", "strongly", "raises", "the", "adsorption", "capacity", "vs", "C0086376#ent", "<e2>", "suggesting", "new", "experiments", "in", "order", "to", "verify", "if", "this", "raises", "or", "lowers", "the", "prion", "infectivity", "."], "h": {"id": "C1423814", "name": "C1423814#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["Paradoxically", ",", "APL", "cells", "express", "C3887967#ent", "<e1>", ",", "an", "aberrant", "form", "of", "the", "C1366536#ent", "<e2>", "RAR", "alpha", "derived", "from", "the", "leukemia-specific", "t(15;17", ")", "chromosomal", "translocation"], "h": {"id": "C3887967", "name": "C3887967#ent", "pos": [5, 6]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [13, 14]}}
{"token": ["As", "C0700580#ent", "<e1>", "to", "be", "a", "more", "effective", "C0006280#ent", "<e2>", "beta", "2-stimulants", "in", "the", "first", "year", "of", "life", ",", "a", "study", "was", "set", "up", "to", "investigate", "its", "possible", "role", "in", "bronchiolitis", "."], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006280", "name": "C0006280#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "although", "all", "tumours", "contained", "C0000294#ent", "<e1>", "(", "muscle", "specific", "actin)-positive", "and", "C3273837#ent", "<e2>", "protein-positive", "cells", "these", "regions", "were", "more", "extensive", "in", "the", "tumours", "of", "female", "mice"], "h": {"id": "C0000294", "name": "C0000294#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273837", "name": "C3273837#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "expression", "of", "C4042483#ent", "<e1>", "normal", "and", "C0012634#ent", "<e2>", "renal", "tissue", "to", "define", "any", "correlation", "with", "the", "type", "of", "renal", "injury"], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["C0770909#ent", "<e1>", "and", "verapamil", ",", "Ca2", "+", "C3494348#ent", "<e2>", "can", "completely", "inhibit", "this", "binding", "at", "nM", "concentrations", "."], "h": {"id": "C0770909", "name": "C0770909#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [7, 8]}}
{"token": ["A", "spontaneously", "beating", "guinea", "pig", "Langendorff", "heart", "preparation", "was", "used", "to", "evaluate", "and", "compare", "the", "effects", "of", "C0770909#ent", "<e1>", "BP", ")", "and", "other", "C3494348#ent", "<e2>"], "h": {"id": "C0770909", "name": "C0770909#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [23, 24]}}
{"token": ["To", "investigate", "the", "molecular", "mechanism", "inhibitory", "effect", "of", "Salvia", "miltiorrhiza", "Injection", "(", "SMI", ")", "coordinated", "with", "C0011777#ent", "<e1>", "(", "DXM", ")", "on", "allergic", "airway", "inflammation", "in", "C0004096#ent", "<e2>", "rats", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [16, 17]}, "relation": "may_prevent", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [26, 27]}}
{"token": ["These", "results", "demonstrate", "that", "C0011777#ent", "<e1>", "not", "only", "prevents", "but", "also", "halts", "the", "C0004096#ent", "<e2>", "induced", "by", "house", "dust", "cockroach", "allergens"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}}
{"token": ["This", "study", "was", "designed", "to", "quantify", "the", "blood", "stagnation", "left", "atrial", "appendages", "C1337080#ent", "<e1>", ")", "of", "patients", "with", "C0264766#ent", "<e2>", "and", "to", "stratify", "the", "risk", "of", "spontaneous", "echo", "contrast", "(", "SEC", ")", "for", "thrombus", "formation"], "h": {"id": "C1337080", "name": "C1337080#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0264766", "name": "C0264766#ent", "pos": [18, 19]}}
{"token": ["A", "C0684275#ent", "<e1>", "patient", "with", "crippling", "C0029410#ent", "<e2>", "described", "in", "whom", "arthrodeses", "of", "the", "left", "knee", "right", "ankle", "total", "replacement", "the", "left", "ankle", "performed", "in", "the", "course", "of", "one", "operation", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029410", "name": "C0029410#ent", "pos": [6, 7]}}
{"token": ["Finally", ",", "we", "suggest", "that", "C0341305#ent", "<e1>", "be", "suspected", "in", "the", "face", "of", "unaccounted", "acute", "or", "C1306587#ent", "<e2>", "high", "levels", "of", "antithyroid", "antibodies"], "h": {"id": "C0341305", "name": "C0341305#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1306587", "name": "C1306587#ent", "pos": [16, 17]}}
{"token": ["C0011269#ent", "<e1>", "VD", ")", "and", "Alzheimer-type", "dementia", "C1412613#ent", "<e2>", ")", "are", "two", "main", "causes", "of", "dementia", "in", "the", "aged", ",", "accounting", "for", "more", "than", "90", "%", "of", "cases", "with", "dementia", "."], "h": {"id": "C0011269", "name": "C0011269#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412613", "name": "C1412613#ent", "pos": [7, 8]}}
{"token": ["There", "appear", "to", "be", "two", "classes", "of", "C0030940#ent", "<e1>", "rat", "heart", "and", "adipose", "tissue", "types", "I", "C3273406#ent", "<e2>", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [16, 17]}}
{"token": ["Although", "it", "is", "known", "that", "renal", "amyloidosis", "complicate", "several", "dermatoses", ",", "C0079294#ent", "<e1>", "RDEB", ")", "complicated", "by", "C0017661#ent", "<e2>", "has", "been", "thought", "to", "be", "rare", "."], "h": {"id": "C0079294", "name": "C0079294#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "tested", "the", "tolerance", "and", "therapeutic", "effect", "desopimon", "preparation", "(", "1-p-chlorophenyl-2-aminopropane", "C0546849#ent", "<e1>", ")", "in", "44", "subjects", "with", "obesity", "--", "I", ",", "C3273406#ent", "<e2>", "and", "III", "degree", "."], "h": {"id": "C0546849", "name": "C0546849#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [23, 24]}}
{"token": ["These", "tests", "included", "catalase-peroxidase", ",", "C0206528#ent", "<e1>", ",", "hippurate", "hydrolysis", "starch", "hydrolysis", ",", "medium", "browning", "acetoin", "production", ",", "C0242417#ent", "<e2>", ",", "medium", "fluorescence", "colony", "fluorescence", "and", "the", "bromcresol", "purple", "spot", "test"], "h": {"id": "C0206528", "name": "C0206528#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242417", "name": "C0242417#ent", "pos": [18, 19]}}
{"token": ["The", "refractive", "index", "single", "microparticles", "is", "derived", "from", "precise", "measurement", "and", "C0026837#ent", "<e1>", "modeling", "of", "the", "stiffness", "of", "a", "C1705620#ent", "<e2>"], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705620", "name": "C1705620#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "we", "provide", "evidence", "that", "C0812229#ent", "<e1>", "also", "acts", "in", "vivo", "promote", "beta-catenin", "degradation", "in", "regulating", "mammalian", "C0030196#ent", "<e2>", "development", "and", "possibly", "in", "suppressing", "tumor", "formation"], "h": {"id": "C0812229", "name": "C0812229#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [18, 19]}}
{"token": ["C3714753#ent", "<e1>", ",", "also", "known", "as", "C0152439#ent", "<e2>", ",", "is", "an", "extracellular", "discoidin", "domain-containing", "protein", "has", "been", "implicated", "in", "maintaining", "the", "cellular", "organization", "synaptic", "structure", "the", "vertebrate", "retina"], "h": {"id": "C3714753", "name": "C3714753#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0152439", "name": "C0152439#ent", "pos": [6, 7]}}
{"token": ["Upon", "C0002949#ent", "<e1>", "muscle", "regeneration", "earlier", "and", "was", "completed", "faster", "than", "in", "C2987364#ent", "<e2>", "(", "WT", ")", "control", "."], "h": {"id": "C0002949", "name": "C0002949#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}}
{"token": ["When", "cultivated", "with", "Aspergillus", "niger", "C0061200#ent", "<e1>", ",", "an", "important", "C0013227#ent", "<e2>", ",", "is", "transformed", "into", "genipin", "and", "genipinine", "."], "h": {"id": "C0061200", "name": "C0061200#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["By", "contrast", ",", "the", "stable", "binding", "with", "C1540154#ent", "<e1>", "conferred", "by", "other", "domains", "of", "C1419040#ent", "<e2>", "is", "not", "required", "for", "C1419040#ent", "<e2>", "degradation", "."], "h": {"id": "C1540154", "name": "C1540154#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419040", "name": "C1419040#ent", "pos": [14, 15]}}
{"token": ["The", "ubiquitin-conjugating", "enzyme", "Rad6", "which", "directly", "interacts", "with", "C1540154#ent", "<e1>", ",", "is", "also", "required", "for", "the", "ubiquitin-dependent", "degradation", "C1419040#ent", "<e2>", "."], "h": {"id": "C1540154", "name": "C1540154#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419040", "name": "C1419040#ent", "pos": [18, 19]}}
{"token": ["A", "C0812288#ent", "<e1>", "PTK", ")", "of", "the", "C0059239#ent", "<e2>", "FAK", ")", "subfamily", ",", "cell", "adhesion", "kinase", "beta", "CAK", "beta", ")", ",", "was", "identified", "by", "cDNA", "cloning"], "h": {"id": "C0812288", "name": "C0812288#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [7, 8]}}
{"token": ["A", "novel", "C0812288#ent", "<e1>", "designated", "'", "Focal", "Adhesion", "Kinase", "'", "(", "C0059239#ent", "<e2>", ")", ",", "has", "recently", "been", "implicated", "in", "signal", "transduction", "pathways", "activated", "by", "extracellular", "adhesion", "molecules", "and", "by", "neuropeptide", "growth", "factors"], "h": {"id": "C0812288", "name": "C0812288#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [11, 12]}}
{"token": ["C0966149#ent", "<e1>", "increased", "the", "phosphorylation", "of", "C0812228#ent", "<e2>", "and", "decreased", "PTEN", "expression", "."], "h": {"id": "C0966149", "name": "C0966149#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [6, 7]}}
{"token": ["Much", "evidence", "now", "indicates", "that", "Abeta", "multimers", "can", "trigger", "neurodegenerative", "changes", "involve", "formation", "of", "dystrophic", "neurites", "and", "C1333200#ent", "<e1>", "possibly", "due", "loss", "of", "microtubule", "MT", ")", "stabilization", "by", "the", "C1421563#ent", "<e2>"], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1421563", "name": "C1421563#ent", "pos": [29, 30]}}
{"token": ["As", "a", "group", ",", "young", "C0948740#ent", "<e1>", "children", "and", "girls", "with", "C0041408#ent", "<e2>", "a", "high", "SFF", ",", "and", "prepubertal", "boys", "with", "delayed", "maturation", "a", "low", "SFF", "."], "h": {"id": "C0948740", "name": "C0948740#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041408", "name": "C0041408#ent", "pos": [11, 12]}}
{"token": ["Six", "proteins", "were", "identified", "by", "peptide", "sequence", "analysis", "including", "C0050690#ent", "<e1>", "a", "trifunctional", "enzyme", "the", "peroxisomal", "beta-oxidation", "system", "well", "as", "peroxisomal", "malate", "dehydrogenase", "3", "C0007259#ent", "<e2>"], "h": {"id": "C0050690", "name": "C0050690#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007259", "name": "C0007259#ent", "pos": [24, 25]}}
{"token": ["C0384392#ent", "<e1>", "recently", "added", "to", "the", "cyclin", "family", "C0086376#ent", "<e2>", "because", "of", "the", "presence", "of", "a", "cyclin", "box", "motif", "in", "the", "deduced", "amino-acid", "sequence"], "h": {"id": "C0384392", "name": "C0384392#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["We", "investigated", "the", "role", "of", "two", "leukotriene", "B4", "LTB4", ")", "receptors", ",", "C1708627#ent", "<e1>", "and", "peroxisome", "proliferator-activated", "receptor", ",", "in", "conferring", "the", "susceptibility", "to", "develop", "C0024117#ent", "<e2>", "in", "smokers", "."], "h": {"id": "C1708627", "name": "C1708627#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [25, 26]}}
{"token": ["This", "series", "illustrates", "the", "difficulty", "of", "establishing", "an", "accurate", "preoperative", "diagnosis", ",", "and", "the", "propensity", "of", "intestinal", "endometriosis", "mimic", "other", "C0017178#ent", "<e1>", "particularly", "carcinoma", "and", "C0010346#ent", "<e2>"], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [20, 21]}, "relation": "nichd_parent_of", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [25, 26]}}
{"token": ["Thymidine", "was", "reacted", "in", "methanol", "with", "four", "C3542457#ent", "<e1>", "of", "varying", "mutagenicities", ":", "C0040903#ent", "<e2>", "glycidol", ",", "epichlorohydrin", "and", "trichloropropylene", "oxide"], "h": {"id": "C3542457", "name": "C3542457#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040903", "name": "C0040903#ent", "pos": [13, 14]}}
{"token": ["After", "inhalation", "exposure", ",", "1,2-epoxybutane", "was", "carcinogenic", "in", "rodents", "as", "were", "other", "C3542457#ent", "<e1>", "or", "related", "compounds", "including", "C0040903#ent", "<e2>", "1,3-butadiene", ",", "and", "ethylene", "oxide"], "h": {"id": "C3542457", "name": "C3542457#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040903", "name": "C0040903#ent", "pos": [18, 19]}}
{"token": ["These", "are", "contrasted", "with", "the", "abnormal", "changes", "in", "infections", ",", "especially", "fungal", ",", "of", "the", "nail", "unit", "and", "in", "C0037274#ent", "<e1>", "may", "affect", "the", "nail", ",", "especially", "C0033860#ent", "<e2>", "and", "lichen", "planus"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [19, 20]}, "relation": "nichd_parent_of", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [27, 28]}}
{"token": ["The", "clinical", "symptoms", "premature", "ageing", "syndromes", "such", "as", "progeria", ",", "C0221032#ent", "<e1>", "Cockayne", "syndrome", "metageria", "and", "C0238590#ent", "<e2>", "are", "summarized", "briefly", "and", "compared", "with", "the", "clinical", "picture", "in", "our", "patient", "."], "h": {"id": "C0221032", "name": "C0221032#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0238590", "name": "C0238590#ent", "pos": [16, 17]}}
{"token": ["C0917831#ent", "<e1>", "would", "seem", "to", "be", "the", "preferable", "C0013227#ent", "<e2>", "for", "use", "in", "outpatients", "undergoing", "minor", "surgical", "operations"], "h": {"id": "C0917831", "name": "C0917831#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}}
{"token": ["A", "diagnosis", "of", "DM", "was", "made", ",", "and", "prednisolone", "was", "given", "with", "improvement", "of", "the", "C0521471#ent", "<e1>", "but", "deteriorating", "C0026848#ent", "<e2>", "."], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [19, 20]}}
{"token": ["The", "patient", "had", "no", "features", "of", "C0410787#ent", "<e1>", "furthermore", ",", "a", "skin", "biopsy", "no", "signs", "C0024796#ent", "<e2>", "Ehlers", "Danlos", "Syndrome"], "h": {"id": "C0410787", "name": "C0410787#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [15, 16]}}
{"token": ["These", "effects", "were", "inhibited", "in", "C1366526#ent", "<e1>", "to", "express", "C0376515#ent", "<e2>", "(", "PC3-bcl2", ")", "."], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "the", "human", "prostatic", "carcinoma", "cell", "line", "C1366526#ent", "<e1>", "was", "sensitive", "to", "TRAIL", "treatment", "whereas", "C1366526#ent", "<e1>", "overexpressing", "of", "C0376515#ent", "<e1>", "was", "resistant", "."], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [22, 23]}}
{"token": ["A", "study", "was", "carried", "out", "to", "compare", "the", "efficacy", "and", "tolerability", "of", "etodolac", "and", "C0031990#ent", "<e1>", "in", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["Open", "non-comparative", "study", "the", "evaluation", "of", "the", "efficacy", "and", "tolerance", "of", "C0031990#ent", "<e1>", "FDDF", "for", "sublingual", "administration", "in", "the", "treatment", "of", "C0003873#ent", "<e2>"], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}}
{"token": ["These", "data", "show", "that", "C0031990#ent", "<e1>", "decreases", "the", "T4/T8", "cell", "in", "active", "C0003873#ent", "<e2>", ",", "but", "only", "48", "h", "after", "the", "first", "administration.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}}
{"token": ["C0764105#ent", "<e1>", ",", "papain", ",", "thermolysin", "and", "C0293742#ent", "<e2>", "adsorbed", "on", "Celite", "were", "used", "as", "catalysts", "."], "h": {"id": "C0764105", "name": "C0764105#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0293742", "name": "C0293742#ent", "pos": [7, 8]}}
{"token": ["In", "this", "report", ",", "we", "describe", "a", "patient", "with", "Sj\u00f6gren's", "syndrome", "fulfilled", "the", "diagnostic", "criteria", "AC", "associated", "with", "C0003892#ent", "<e1>", "compatible", "with", "arthritis", "of", "C0008312#ent", "<e2>", "."], "h": {"id": "C0003892", "name": "C0003892#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [24, 25]}}
{"token": ["Among", "C1415067#ent", "<e1>", "patients", ",", "a", "hierarchical", "regression", "revealed", "that", "GIP-associated", "trauma", "recall", "and", "catastrophic", "cognitions", "explained", "variance", "in", "C1415067#ent", "<e1>", "severity", "beyond", "a", "measure", "of", "general", "psychopathology", "C1704894#ent", "<e1>", ")", "."], "h": {"id": "C1415067", "name": "C1415067#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704894", "name": "C1704894#ent", "pos": [28, 29]}}
{"token": ["Cellular", "expression", "C1424139#ent", "<e1>", "neither", "stabilised", "C1332803#ent", "<e2>", "nor", "activated", "the", "lymphoid", "enhancer", "factor", "T-cell", "factor", "transcriptional", "reporter", "primary", "keratinocytes"], "h": {"id": "C1424139", "name": "C1424139#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [6, 7]}}
{"token": ["No", "significant", "correlations", "were", "detected", "between", "C2698419#ent", "<e1>", "immunoreactivity", "and", "amounts", "of", "C0003805#ent", "<e2>", "mRNA", "."], "h": {"id": "C2698419", "name": "C2698419#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [12, 13]}}
{"token": ["In", "one", "case", "an", "C0024730#ent", "<e1>", "dose", "(", "20", "%", ")", "plus", "C0071042#ent", "<e2>", "given", ",", "in", "the", "other", "enema", "plus", "bisacodyl", "was", "applied", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0071042", "name": "C0071042#ent", "pos": [12, 13]}}
{"token": ["To", "compare", "the", "effects", "of", "cardioselective", "beta-blocker", "C0068475#ent", "<e1>", ")", "with", "those", "of", "an", "angiotensin-converting", "enzyme", "inhibitor", "C0014025#ent", "<e2>", ")", "on", "parameters", "of", "insulin", "sensitivity", "peripheral", "blood", "flow", "arterial", "stiffness", "one", "extended", "glucose", "clamp", "experiment", "."], "h": {"id": "C0068475", "name": "C0068475#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [17, 18]}}
{"token": ["We", "propose", "that", "the", "enzyme", "is", "a", "member", "of", "the", "C3887697#ent", "<e1>", "family", "2", "which", "comprises", "mitochondrially", "bound", "enzymes", ",", "with", "C1096793#ent", "<e2>", "as", "the", "direct", "electron", "acceptor", "oxygen", "as", "the", "final", "electron", "acceptor"], "h": {"id": "C3887697", "name": "C3887697#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1096793", "name": "C1096793#ent", "pos": [21, 22]}}
{"token": ["Drugs", ",", "particularly", "C0027409#ent", "<e1>", "are", "important", "factors", "in", "the", "C4255166#ent", "<e2>", "of", "severe", "constipation", "."], "h": {"id": "C0027409", "name": "C0027409#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4255166", "name": "C4255166#ent", "pos": [10, 11]}}
{"token": ["C0271814#ent", "<e1>", "a", "common", "form", "of", "C0040147#ent", "<e2>", "yields", "very", "few", "clinical", "symptoms", "signs", "but", "significant", "alterations", "in", "biological", "tests", "including", "a", "thyroid", "131I", "uptake", "compatible", "with", "silent", "thyroid", "destruction"], "h": {"id": "C0271814", "name": "C0271814#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040147", "name": "C0040147#ent", "pos": [6, 7]}}
{"token": ["In", "this", "review", ",", "the", "pathology", "of", "the", "various", "subtypes", "of", "chronic", "thyroiditis", "enumerated", ",", "including", "recently", "defined", "lesions", ",", "i.e.", ",", "C0271814#ent", "<e1>", "thyroiditis", "associated", "with", "interleukin", "chemotherapy", "and", "C0040147#ent", "<e2>", "reviewed", "."], "h": {"id": "C0271814", "name": "C0271814#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0040147", "name": "C0040147#ent", "pos": [30, 31]}}
{"token": ["Silent", "or", "C0271814#ent", "<e1>", "was", "termed", "C0040147#ent", "<e2>", "without", "clear", "cause", "or", "after", "adrenectomy", "for", "Cushing", "syndrome"], "h": {"id": "C0271814", "name": "C0271814#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040147", "name": "C0040147#ent", "pos": [6, 7]}}
{"token": ["It", "could", "be", "demonstrated", "that", "the", "C0020289#ent", "<e1>", "phosphatase", ",", "RNase", ",", "and", "C1257646#ent", "<e2>", "of", "the", "mitochondrial", "fraction", "contained", "in", "membrane-bound", "particles"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [13, 14]}}
{"token": ["The", "main", "C0020289#ent", "<e1>", "detected", "were", ";", "acid", "phosphatase", "beta-glucosidase", ",", "C1257646#ent", "<e2>", ",", "beta-galactosidase", ",", "esterase", "lipase", "and", "lipase", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [11, 12]}}
{"token": ["This", "study", "targets", "another", "kind", "of", "C0020289#ent", "<e1>", ",", "carboxylic", "esterase", "with", "the", "objectives", "of", "identifying", "C1257646#ent", "<e2>", "determining", "whether", "it", "is", "a", "protective", "antigen"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [16, 17]}}
{"token": ["Assessment", "of", "the", "cost-effectiveness", "and", "cost-utility", "of", "early", "intervention", "in", "C0038013#ent", "<e1>", "RA", ")", "patients", ",", "with", "combined", "step-down", "C0032950#ent", "<e2>", ",", "methotrexate", "and", "sulphasalazine", ",", "compared", "to", "sulphasalazine", "alone", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [19, 20]}}
{"token": ["A", "78-year-old", "woman", "had", "a", "30-year", "history", "of", "C0038013#ent", "<e1>", "of", "late", "treated", "with", "C0032950#ent", "<e2>", "and", "methotrexate", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "C0282145#ent", "<e1>", "and", "loperamide", "have", "gained", "wide", "clinical", "application", "nonspecific", "C0003292#ent", "<e2>"], "h": {"id": "C0282145", "name": "C0282145#ent", "pos": [2, 3]}, "relation": "has_therapeutic_class", "t": {"id": "C0003292", "name": "C0003292#ent", "pos": [12, 13]}}
{"token": ["Because", "interaction", "between", "retinoids", "and", "C3265062#ent", "<e1>", "occur", "at", "different", "levels", "during", "signal", "transduction", "it", "is", "not", "possible", "to", "predict", "from", "our", "results", "whether", "C0003873#ent", "<e2>", "will", "inhibit", "the", "effects", "of", "C3265062#ent", "<e1>", "in", "vivo"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C3265062", "name": "C3265062#ent", "pos": [5, 6]}}
{"token": ["Our", "observations", "suggest", "that", "C1419942#ent", "<e1>", "a", "limited", "role", "during", "restriction", "of", "developing", "C0152177#ent", "<e2>", "axons", "to", "proper", "pathways", "and", "tracts", "."], "h": {"id": "C1419942", "name": "C1419942#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0152177", "name": "C0152177#ent", "pos": [13, 14]}}
{"token": ["This", "experimental", "system", "employed", "to", "further", "study", "the", "hypothesis", "that", "atopic", "disease", "C0004096#ent", "<e1>", "to", "atopy", "might", "be", "associated", "with", "C1367657#ent", "<e2>"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [20, 21]}}
{"token": ["MSP", "in", "C1825705#ent", "<e1>", "supernatant", "and", "rMSP", "induced", "in", "C0220742#ent", "<e2>", "phosphorylation", "of", "RON", ",", "growth", ",", "migration", ",", "invasion", ",", "and", "IL-6", "synthesis", "."], "h": {"id": "C1825705", "name": "C1825705#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220742", "name": "C0220742#ent", "pos": [9, 10]}}
{"token": ["A", "direct", "estimation", "of", "localization", "of", "radioactive", "phosphate", "the", "C0031684#ent", "<e1>", "demonstrated", "that", "all", "the", "enumerated", "threonine", "residues", "in", "C1705446#ent", "<e2>", "can", "be", "phosphorylated", "in", "vitro"], "h": {"id": "C0031684", "name": "C0031684#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705446", "name": "C1705446#ent", "pos": [19, 20]}}
{"token": ["C0917713#ent", "<e1>", "be", "associated", "with", "myocardial", "abnormalities", "are", "usually", "diagnosed", "after", "the", "onset", "of", "C3714552#ent", "<e2>", "."], "h": {"id": "C0917713", "name": "C0917713#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [14, 15]}}
{"token": ["The", "cholecystokinin-8", "(CCK-8)-inactivating", "peptidase", "is", "a", "C0030940#ent", "<e1>", "has", "been", "shown", "to", "be", "a", "membrane-bound", "isoform", "C0077246#ent", "<e2>", "EC", "3.4.14.10", ")", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0077246", "name": "C0077246#ent", "pos": [16, 17]}}
{"token": ["One", "of", "these", "C0030940#ent", "<e1>", "was", "identified", "as", "a", "C0077246#ent", "<e2>", "Bb", "TPP", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0077246", "name": "C0077246#ent", "pos": [9, 10]}}
{"token": ["Single", "doses", "C1425526#ent", "<e1>", "were", "administered", "to", "C3273832#ent", "<e2>", "22.5", "or", "45", "mg/kg", "and", "blood", "samples", "on", "days", "3", ",", "7", "and", "14", "for", "haematological", "examination", "clinical", "chemistry"], "h": {"id": "C1425526", "name": "C1425526#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273832", "name": "C3273832#ent", "pos": [7, 8]}}
{"token": ["The", "C0242947#ent", "<e1>", "atropine", "and", "pirenzepine", ",", "blocked", "the", "carbachol-induced", "C2697645#ent", "<e2>", "accumulation", "with", "Ki", "values", "of", "0.3", "and", "30", "nM", ",", "respectively", "."], "h": {"id": "C0242947", "name": "C0242947#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2697645", "name": "C2697645#ent", "pos": [10, 11]}}
{"token": ["The", "neural", "tracer", "cholera", "toxin", "B", "C0111753#ent", "<e1>", ")", "was", "injected", "into", "the", "extensor", "digitorum", "communis", "C1832097#ent", "<e2>", ")", "at", "either", "P14", "or", "P28", "."], "h": {"id": "C0111753", "name": "C0111753#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1832097", "name": "C1832097#ent", "pos": [16, 17]}}
{"token": ["The", "intent", "of", "this", "study", "was", "to", "assess", "the", "effect", "of", "low-dose", "methotrexate", "treatment", "on", "bone", "mineral", "density", "C1826421#ent", "<e1>", ")", "in", "patients", "with", "C3899278#ent", "<e2>", "RA", ")", "."], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3899278", "name": "C3899278#ent", "pos": [24, 25]}}
{"token": ["The", "significant", "streaking", "of", "radioactivity", "on", "the", "ITLC/SG", "C0752313#ent", "<e1>", "strip", "of", "the", "C3541334#ent", "<e2>", "method", "indicates", "that", "ITLC/SG", "C0752313#ent", "<e1>", "may", "not", "be", "an", "ideal", "system", "for", "RCP", "analysis", "of", "99Tcm-exametazime", "."], "h": {"id": "C3541334", "name": "C3541334#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [8, 9]}}
{"token": ["We", "also", "crossed", "C1844376#ent", "<e1>", "mice", "with", "C1704299#ent", "<e2>", "apoE-/-", ")", "mice", "to", "generate", "spontaneously", "hypercholesterolemic", "animals", "that", "lacked", "functional", "NADPH", "oxidase"], "h": {"id": "C1844376", "name": "C1844376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704299", "name": "C1704299#ent", "pos": [7, 8]}}
{"token": ["C1428913#ent", "<e1>", "localizes", "exclusively", "to", "the", "nucleus", "and", "colocalizes", "with", "C1414929#ent", "<e2>", "."], "h": {"id": "C1428913", "name": "C1428913#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414929", "name": "C1414929#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "the", "promoter", "region", "specific", "to", "C2350736#ent", "<e1>", "subject", "to", "regulation", "by", "ATRA", "and", "C1334103#ent", "<e2>", "."], "h": {"id": "C2350736", "name": "C2350736#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334103", "name": "C1334103#ent", "pos": [15, 16]}}
{"token": ["Although", "inhibition", "was", "associated", "with", "functional", "heat-stable", "antigen", "a", "C2985420#ent", "<e1>", "on", "macrophages", ",", "C1705616#ent", "<e2>", "exposure", "did", "not", "alter", "cell", "surface", "heat-stable", "antigen", "expression", "."], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "we", "showed", "that", "C1424222#ent", "<e1>", ",", "a", "yeast", "DnaJ", "homolog", "to", "the", "Hsp40", "family", "chaperones", ",", "C1516876#ent", "<e2>", "interacts", "with", "Cdc37", "."], "h": {"id": "C1424222", "name": "C1424222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [19, 20]}}
{"token": ["We", "mapped", "the", "C1424222#ent", "<e1>", "locus", "to", "chromosome", "1p36", "a", "large", "family", "from", "a", "C1516876#ent", "<e2>", "isolated", "population", "in", "the", "Netherlands", ",", "and", "confirmed", "this", "linkage", "in", "an", "Italian", "family"], "h": {"id": "C1424222", "name": "C1424222#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [14, 15]}}
{"token": ["The", "C1414051#ent", "<e1>", "D1", ")", "catalyzes", "the", "activation", "of", "C2936885#ent", "<e2>", "to", "T3", "as", "well", "as", "the", "degradation", "of", "T3", "(", "rT3", ")", "and", "sulfated", "iodothyronines", "."], "h": {"id": "C1414051", "name": "C1414051#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2936885", "name": "C2936885#ent", "pos": [9, 10]}}
{"token": ["C1414051#ent", "<e1>", "D1", ")", "catalyses", "the", "5", "'", "monodeiodination", "of", "C2936885#ent", "<e2>", "and", "is", "highly", "expressed", "in", "normal", "human", "thyroid", "gland"], "h": {"id": "C1414051", "name": "C1414051#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936885", "name": "C2936885#ent", "pos": [10, 11]}}
{"token": ["C0169658#ent", "<e1>", "Jak3", ")", "is", "a", "C1336653#ent", "<e2>", "coupled", "to", "cytokine", "receptors", "share", "a", "\"", "common", "\"", "gamma", "chain", "gamma", "c", "."], "h": {"id": "C0169658", "name": "C0169658#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336653", "name": "C1336653#ent", "pos": [6, 7]}}
{"token": ["Although", "lacking", "a", "transmembrane", "sequence", "C4277632#ent", "<e1>", "is", "retained", "near", "the", "cell", "surface", "well", "as", "in", "the", "C1417215#ent", "<e2>", "of", "transiently", "transfected", "COS-1", "and", "293", "cells"], "h": {"id": "C4277632", "name": "C4277632#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417215", "name": "C1417215#ent", "pos": [17, 18]}}
{"token": ["Most", "of", "the", "patients", "were", "elderly", ",", "with", "diminished", "pulses", ",", "a", "C0151313#ent", "<e1>", "and", "a", "C0275524#ent", "<e2>"], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [16, 17]}}
{"token": ["C0013456#ent", "<e1>", "and", "pains", "are", "commonly", "seen", "in", "general", "practice", "C0029408#ent", "<e2>", "may", "be", "an", "underlying", "cause", "."], "h": {"id": "C0013456", "name": "C0013456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [10, 11]}}
{"token": ["Hemophilus", "influenzae", "C0005244#ent", "<e1>", "negative", "was", "the", "main", "organism", "recovered", "from", "BAL", "in", "C0010674#ent", "<e2>", "patients", "with", "recurrent", "or", "persistent", "pneumonia", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [13, 14]}}
{"token": ["Despite", "accumulating", "evidence", "for", "the", "C0004096#ent", "<e1>", "of", "platelets", ",", "the", "primary", "regulator", "thrombopoiesis", ",", "thrombopoietin", "(", "C0812443#ent", "<e2>", ")", ",", "has", "not", "yet", "been", "studied", "in", "renal", "transplant", "recipients", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [17, 18]}}
{"token": ["Despite", "accumulating", "evidence", "for", "the", "C0004096#ent", "<e1>", "of", "platelets", ",", "the", "primary", "regulator", "thrombopoiesis", ",", "C0812443#ent", "<e2>", "(", "TPO", ")", ",", "has", "not", "yet", "been", "studied", "in", "renal", "transplant", "recipients", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [15, 16]}}
{"token": ["Despite", "accumulating", "evidence", "for", "the", "C0004096#ent", "<e1>", "of", "platelets", ",", "the", "primary", "regulator", "C0812443#ent", "<e2>", ",", "thrombopoietin", "(", "TPO", ")", ",", "has", "not", "yet", "been", "studied", "in", "renal", "transplant", "recipients", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [13, 14]}}
{"token": ["A", "large", "Danish", "family", "has", "previously", "been", "reported", "in", "which", "autosomal", "dominant", "frontotemporal", "dementia", "C0338451#ent", "<e1>", ")", "is", "genetically", "linked", "to", "chromosome", "3", "C1833296#ent", "<e2>", ")", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C1833296", "name": "C1833296#ent", "pos": [23, 24]}}
{"token": ["We", "have", "previously", "reported", "a", "large", "Danish", "pedigree", "autosomal", "dominant", "frontotemporal", "dementia", "C0338451#ent", "<e1>", ")", "linked", "to", "chromosome", "3", "C1833296#ent", "<e2>", ")", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C1833296", "name": "C1833296#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "the", "CHMP2B", "gene", "been", "recently", "identified", "in", "a", "large", "Danish", "pedigree", "autosomal", "dominant", "C0338451#ent", "<e1>", "FTD", ")", "linked", "to", "chromosome", "3", "C1833296#ent", "<e2>", ")", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C1833296", "name": "C1833296#ent", "pos": [23, 24]}}
{"token": ["Effective", "non-genotoxic", "inducers", "included", "phenobarbital", "and", "some", "structurally", "related", "compounds", ",", "p", ",", "p'-dichlorodiphenyltrichloroethane", ",", "alpha-", "and", "gamma-hexachlorocyclohexanes", ",", "Aroclor", "1254", "butyl", "hydroxytoluene", "C0027326#ent", "<e1>", ",", "various", "estrogens", ",", "progesterone", ",", "pregnenolone-16", "alpha-carbonitrile", "C0010621#ent", "<e2>"], "h": {"id": "C0027326", "name": "C0027326#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0010621", "name": "C0010621#ent", "pos": [33, 34]}}
{"token": ["pVHL", "is", "found", "in", "a", "multiprotein", "complex", "elongins", "B/C", ",", "C1332810#ent", "<e1>", ",", "and", "Rbx1", "forming", "an", "C0077678#ent", "<e2>", "VEC", "."], "h": {"id": "C1332810", "name": "C1332810#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [17, 18]}}
{"token": ["In", "the", "140th", "day", ",", "all", "patients", "were", "positive", "for", "C1705784#ent", "<e1>", "and", "C22", "and", "C1706586#ent", "<e2>", "while", "anti", "C100", "was", "present", "in", "64", "%", "."], "h": {"id": "C1705784", "name": "C1705784#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [15, 16]}}
{"token": ["Among", "this", "clinical", "complexity", "vocal", "cord", "abductor", "paralysis", "SCA1", ",", "familial", "parkinsonism", "C0752121#ent", "<e1>", ",", "vestibular", "dysfunction", "axonal", "neuropathy", "MJD", ",", "and", "C0027066#ent", "<e2>", "SCA14", ",", "are", "reviewed", "for", "potential", "usefulness", "in", "clinical", "practice"], "h": {"id": "C0752121", "name": "C0752121#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0027066", "name": "C0027066#ent", "pos": [22, 23]}}
{"token": ["The", "rictor/Avo3", "homologue", ",", "Ste20", ",", "and", "the", "Avo1", "homologue", ",", "Sin1", ",", "appear", "to", "form", "TORC2", "mainly", "with", "C4085195#ent", "<e1>", "but", "may", "also", "bind", "C4284889#ent", "<e2>", "."], "h": {"id": "C4085195", "name": "C4085195#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4284889", "name": "C4284889#ent", "pos": [25, 26]}}
{"token": ["We", "recently", "demonstrated", "that", "MBD4", "possesses", "the", "ability", "to", "repress", "transcription", "through", "C1417098#ent", "<e1>", "and", "is", "associated", "with", "methylated", "promoters", "in", "the", "CDKN2A", "and", "C0879389#ent", "<e2>", "genes", "."], "h": {"id": "C1417098", "name": "C1417098#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0879389", "name": "C0879389#ent", "pos": [24, 25]}}
{"token": ["The", "chum", "salmon", "C1364160#ent", "<e1>", "was", "deglycosylated", "and", "digested", "with", "several", "C0030940#ent", "<e2>", "in", "series", "."], "h": {"id": "C1364160", "name": "C1364160#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [11, 12]}}
{"token": ["However", ",", "four", "years", "after", "the", "diagnosis", "of", "the", "disease", ",", "C0037507#ent", "<e1>", "became", "ineffective", "and", "oral", "administration", "alendronate", ",", "a", "stronger", "C0012544#ent", "<e2>", ",", "was", "started", "at", "5", "mg/day", "."], "h": {"id": "C0037507", "name": "C0037507#ent", "pos": [11, 12]}, "relation": "has_chemical_structure", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [22, 23]}}
{"token": ["The", "activity", "varies", "greatly", "from", "compound", "to", "compound", ",", "the", "newest", "bisphosphonates", "being", "5,000", "to", "10,000", "times", "more", "active", "than", "C0037507#ent", "<e1>", ",", "the", "first", "C0012544#ent", "<e2>", "described", "."], "h": {"id": "C0037507", "name": "C0037507#ent", "pos": [20, 21]}, "relation": "has_chemical_structure", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [25, 26]}}
{"token": ["We", "recently", "identified", "BBS1", ",", "the", "C0017337#ent", "<e1>", "most", "commonly", "involved", "in", "C2936862#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936862", "name": "C2936862#ent", "pos": [12, 13]}}
{"token": ["A", "positional", "cloning", "approach", "being", "used", "to", "identify", "the", "C0017337#ent", "<e1>", "responsible", "for", "C2936862#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2936862", "name": "C2936862#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicated", "that", "SWR-0342SA", "is", "a", "selective", "beta3-AR", "agonist", ",", "and", "possesses", "potent", "C0935929#ent", "<e1>", "and", "that", "the", "C0376607#ent", "<e2>", "inferior", "to", "the", "C0935929#ent", "<e1>"], "h": {"id": "C0376607", "name": "C0376607#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [14, 15]}}
{"token": ["Apoptosis", ",", "which", "can", "be", "suppressed", "by", "increased", "Wnt-signaling", ",", "was", "attenuated", "by", "the", "C0162429#ent", "<e1>", "P", "<", "0.05", ")", "but", "not", "by", "C0723338#ent", "<e2>", "or", "doublet", "deficiencies", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0723338", "name": "C0723338#ent", "pos": [23, 24]}}
{"token": ["The", "family", "seems", "to", "have", "a", "syndrome", "of", "C2936739#ent", "<e1>", "of", "the", "C0771711#ent", "<e2>", ",", "accompanied", "by", "multiple", "cysts", "the", "liver", "and", "kidneys", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "C57BL/6", "mice", "a", "chronic", "infection", "a", "Th2-skewed", "immune", "response", "a", "Th2-shifted", "cytokine", "profile", "C0034068#ent", "<e1>", "severe", "lung", "pathology", "elevated", "serum", "IgE", "C0085082#ent", "<e2>", ",", "and", "cryptococcal", "dissemination", "in", "the", "central", "nervous", "system"], "h": {"id": "C0034068", "name": "C0034068#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085082", "name": "C0085082#ent", "pos": [24, 25]}}
{"token": ["With", "the", "exception", "of", "C1311470#ent", "<e1>", "mutations", "and", "C1851920#ent", "<e2>", "most", "causes", "are", "associated", "with", "presence", "of", "additional", "neurological", "signs", "resulting", "from", "additional", "lesions", "outside", "of", "the", "basal", "ganglia"], "h": {"id": "C1311470", "name": "C1311470#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1851920", "name": "C1851920#ent", "pos": [8, 9]}}
{"token": ["The", "combination", "of", "optic", "neuropathy", "C0005956#ent", "<e1>", "is", "recognized", "as", "C0027873#ent", "<e2>"], "h": {"id": "C0005956", "name": "C0005956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027873", "name": "C0027873#ent", "pos": [10, 11]}}
{"token": ["C0009324#ent", "<e1>", "be", "differentiated", "from", "C0005943#ent", "<e2>", "the", "bowel", "by", "direct", "search", "for", "the", "relevant", "microorganisms", "and", "by", "serological", "testing"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [5, 6]}}
{"token": ["C1415803#ent", "<e1>", "8-OH-DPAT", ",", "ipsapirone", ",", "and", "C0006462#ent", "<e2>", ")", "and", "5-HT1B", "agonists", "TFMPP", "and", "m-CPP", ")", "affected", "neither", "basal", "nor", "forskolin-dependent", "cyclic", "AMP", "accumulation", "."], "h": {"id": "C1415803", "name": "C1415803#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006462", "name": "C0006462#ent", "pos": [7, 8]}}
{"token": ["RD", ",", "SKI2W", ",", "C1414131#ent", "<e1>", "and", "RP1", "are", "the", "four", "novel", "C1417679#ent", "<e2>", "found", "between", "Bf", "and", "C4", "."], "h": {"id": "C1414131", "name": "C1414131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Retinoic", "acid", "1", "(", "C1414131#ent", "<e1>", ")", "is", "among", "the", "20", "C1417679#ent", "<e2>", "identified", "in", "the", "critical", "region", "Smith-Magenis", "syndrome", "SMS", ")", ",", "a", "genomic", "disorder", "multiple", "congenital", "anomalies", "associated", "with", "3.7", "Mb", "heterozygous", "deletion", "of", "17p11.2", "."], "h": {"id": "C1414131", "name": "C1414131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["Mutations", "in", "multiple", "cardiac", "sarcomeric", "proteins", "including", "myosin", "heavy", "chain", "C1417541#ent", "<e1>", ")", "and", "cardiac", "troponin", "T", "cTnT", ")", "cause", "a", "dominant", "genetic", "heart", "disease", "C0949658#ent", "<e2>", "FHC", ")", "."], "h": {"id": "C1417541", "name": "C1417541#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0949658", "name": "C0949658#ent", "pos": [25, 26]}}
{"token": ["C3469521#ent", "<e1>", "FA", ")", "is", "characterized", "by", "C0030312#ent", "<e2>", ",", "spontaneous", "chromosome", "instability", "and", "a", "variety", "of", "congenital", "anomalies"], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [7, 8]}}
{"token": ["Fanconi", "anemia", "C3469521#ent", "<e1>", ")", ",", "an", "autosomal", "recessive", "disorder", "by", "a", "progressive", "C0030312#ent", "<e2>", "associated", "with", "congenital", "anomalies", "high", "predisposition", "to", "malignancies", ",", "is", "a", "genetically", "and", "clinically", "heterogeneous", "disease", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [13, 14]}}
{"token": ["C3469521#ent", "<e1>", "patients", "are", "characterized", "by", "C0030312#ent", "<e2>", ",", "congenital", "malformations", "growth", "delay", "an", "increased", "susceptibility", "to", "the", "development", "of", "malignancies", ",", "particularly", "acute", "myelogenous", "leukemia"], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [6, 7]}}
{"token": ["Virus-specific", ",", "early", "appearing", "neutralizing", "activities", "(", "C1425409#ent", "<e1>", ")", "and", "interferon", "(", "C1415900#ent", "<e2>", ")", "were", "detected", "in", "tears", "collected", "from", "patients", "during", "epidemics", "of", "acute", "hemorrhagic", "conjunctivitis", "AHC", ")", "."], "h": {"id": "C1425409", "name": "C1425409#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [13, 14]}}
{"token": ["Activation", "of", "receptor", "with", "D-Ala2", ",", "D-Leu5-enkephalin", "(", "C0079286#ent", "<e1>", ")", "resulted", "in", "dose-dependent", "inhibition", "of", "C0917964#ent", "<e2>", "intracellular", "[3H]cAMP", "accumulation", ",", "which", "was", "antagonized", "by", "(-)-naloxone", "but", "not", "(+)-naloxone", "."], "h": {"id": "C0079286", "name": "C0079286#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [16, 17]}}
{"token": ["C1412228#ent", "<e1>", "also", "stimulated", "in", "vivo", "of", "C1366765#ent", "<e2>", "and", "MAP", "kinase", "kinase", "activity"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366765", "name": "C1366765#ent", "pos": [7, 8]}}
{"token": ["Common", "to", "these", "C3812695#ent", "<e1>", "activation", "of", "C0031669#ent", "<e2>", "the", "Gq", "alpha-subunit", "(", "Galpha", "q", ")", "."], "h": {"id": "C3812695", "name": "C3812695#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [7, 8]}}
{"token": ["These", "studies", "therefore", "identify", "C1312419#ent", "<e1>", "as", "a", "critical", "C0031727#ent", "<e2>", "that", "regulates", "ezrin", "phosphorylation", "and", "activation", "."], "h": {"id": "C1312419", "name": "C1312419#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}}
{"token": ["In", "lean", "rats", ",", "MTII", "prevented", "the", "decrease", "in", "brown", "adipose", "tissue", "C1421313#ent", "<e1>", ",", "UCP2", ",", "and", "C1421315#ent", "<e2>", "expression", "and", "muscle", "C1421315#ent", "<e2>", "occurring", "during", "food", "restriction"], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421315", "name": "C1421315#ent", "pos": [18, 19]}}
{"token": ["Since", "the", "discovery", "of", "the", "new", "members", "of", "the", "UCP", "(", "C1421313#ent", "<e1>", "family", ",", "UCP2", "and", "C1421315#ent", "<e2>", ",", "very", "few", "studies", "have", "dealt", "with", "the", "regulation", "of", "their", "expression", "."], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1421315", "name": "C1421315#ent", "pos": [17, 18]}}
{"token": ["Endothelin", "(ET)-1", "is", "an", "endothelium-derived", "vasoconstrictor", "C0026249#ent", "<e1>", "from", "an", "intermediate", "form", "big", "ET-1", ")", "by", "endothelin-converting", "enzyme(s)", "C1414244#ent", "<e2>", ")", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414244", "name": "C1414244#ent", "pos": [18, 19]}}
{"token": ["The", "association", "of", "polymicrogyria", "and", "C0026850#ent", "<e1>", "known", "to", "occur", "in", "Fukuyama", "and", "C0265221#ent", "<e2>", "in", "muscle-eye-brain", "disease", "in", "some", "patients", "with", "merosin", "deficient", "CMD", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0265221", "name": "C0265221#ent", "pos": [13, 14]}}
{"token": ["When", "PKC", "is", "activated", "by", "TPA", ",", "C1367656#ent", "<e1>", "is", "no", "longer", "able", "to", "activate", "C0242957#ent", "<e2>", "in", "T47D", "cells", ",", "leading", "to", "a", "blockage", "of", "cell", "proliferation"], "h": {"id": "C1367656", "name": "C1367656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", "both", "ErbB-3", "and", "ErbB-4", "function", "as", "physiological", "receptors", "all", "C1367656#ent", "<e1>", "isoforms", "and", "suggest", "that", "a", "still", "unknown", "ligand", "of", "C0242957#ent", "<e2>", "exists", "."], "h": {"id": "C1367656", "name": "C1367656#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [24, 25]}}
{"token": ["We", "assess", "night", "and", "day", "function", "of", "the", "C0005697#ent", "<e1>", "children", "with", "C1997362#ent", "<e2>", "overnight", "urodynamic", "monitoring", "and", "conventional", "static", "cystometrogram", "."], "h": {"id": "C0005697", "name": "C0005697#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C1997362", "name": "C1997362#ent", "pos": [12, 13]}}
{"token": ["CMT1A", ",", "CMT1B", ",", "CMTX", ",", "hereditary", "neuropathy", "liability", "to", "pressure", "palsies", "HNPP", ")", ",", "and", "C2698419#ent", "<e1>", "have", "been", "called", "C0012634#ent", "<e2>", "\"", "myelino-pathies", "."], "h": {"id": "C2698419", "name": "C2698419#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [21, 22]}}
{"token": ["It", "is", "uncertain", "whether", "there", "are", "two", "distinct", "yet", "physically", "linked", "genes", "responsible", "for", "C2698419#ent", "<e1>", "and", "HHG", "or", "a", "single", "gene", "for", "both", "C0012634#ent", "<e2>", "."], "h": {"id": "C2698419", "name": "C2698419#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["Gestational", "trophoblastic", "diseases", "C2698419#ent", "<e1>", ")", "include", "a", "spectrum", "of", "C0012634#ent", "<e2>", "from", "the", "potentially", "premalignant", "hydatidiform", "mole", "to", "the", "highly", "aggressive", "choriocarcinoma"], "h": {"id": "C2698419", "name": "C2698419#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["While", "C0010206#ent", "<e1>", "did", "not", "improve", "resistance", "to", "C0036690#ent", "<e2>", "it", "did", "exert", "a", "local", "beneficial", "effect", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [8, 9]}}
{"token": ["Thus", ",", "this", "analysis", "excluded", "C1419600#ent", "<e1>", "as", "the", "C0014077#ent", "<e2>"], "h": {"id": "C1419600", "name": "C1419600#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014077", "name": "C0014077#ent", "pos": [9, 10]}}
{"token": ["To", "characterize", "clinical", "and", "clinicopathologic", "findings", ",", "response", "to", "treatment", ",", "and", "causes", "of", "C0221155#ent", "<e1>", "cats", "with", "C0152132#ent", "<e2>"], "h": {"id": "C0221155", "name": "C0221155#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0152132", "name": "C0152132#ent", "pos": [18, 19]}}
{"token": ["We", "show", "here", "that", "transcription", "of", "the", "mouse", "Ccta", "gene", "regulated", "by", "C1421182#ent", "<e1>", "gene", "transcription", "activating", "factor", "Staf", ")", "family", "zinc-finger", "transcription", "factors", "C1421635#ent", "<e2>", "and", "ZNF76", "."], "h": {"id": "C1421182", "name": "C1421182#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421635", "name": "C1421635#ent", "pos": [24, 25]}}
{"token": ["However", ",", "the", "role", "of", "C0132555#ent", "<e1>", "NOS", ")", "isoforms", "in", "the", "responses", "to", "C0003645#ent", "<e2>", "has", "not", "been", "determined", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003645", "name": "C0003645#ent", "pos": [14, 15]}}
{"token": ["In", "view", "of", "the", "emergence", "of", "C0055461#ent", "<e1>", "resistant", "Plasmodium", "falciparum", "more", "and", "more", "geographical", "areas", "C0072074#ent", "<e2>", "of", "the", "responses", "to", "other", "available", "antimalarials", "by", "in", "vitro", "methods", "have", "become", "essential", "."], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072074", "name": "C0072074#ent", "pos": [16, 17]}}
{"token": ["However", ",", "5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole", "(", "DRB", ")", ",", "which", "is", "a", "specific", "inhibitor", "of", "C0108555#ent", "<e1>", "abolishes", "the", "phosphorylation", "in", "vitro", "BSDL", "within", "micro-", "somes", "C1709385#ent", "<e2>", "-", "2J", "pancreatic", "cells"], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1709385", "name": "C1709385#ent", "pos": [24, 25]}}
{"token": ["Mammalian", "studies", "revealed", "complete", "loss", "of", "binding", "between", "the", "COOH", "terminus", "of", "C1412686#ent", "<e1>", "containing", "the", "G-to-R", "mutant", "and", "PFK-1", ",", "without", "affecting", "C3539630#ent", "<e2>", "catalytic", "activity"], "h": {"id": "C1412686", "name": "C1412686#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539630", "name": "C3539630#ent", "pos": [23, 24]}}
{"token": ["An", "imbalance", "of", "joint", "functioning", "initiates", "the", "C0027721#ent", "<e1>", "which", "is", "then", "worsened", "through", "biochemical", "changes", "in", "the", "C0009325#ent", "<e2>", "in", "the", "joint", "."], "h": {"id": "C0027721", "name": "C0027721#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [18, 19]}}
{"token": ["Rapid", "sequence", "induction", "anaesthesia", "necessitating", "the", "use", "of", "C0012792#ent", "<e1>", "may", "occasionally", "be", "needed", "soon", "after", "antagonism", "of", "neuromuscular", "block", "C0242896#ent", "<e2>"], "h": {"id": "C0012792", "name": "C0012792#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [20, 21]}}
{"token": ["Addition", "of", "C0001497#ent", "<e1>", "not", "affect", "C0001492#ent", "<e2>", "measured", "in", "membranes", "prepared", "from", "brain", ",", "heart", ",", "or", "kidney", ",", "suggesting", "that", "lung", "membranes", "contain", "more", "nucleotide", "pyrophosphatase", "less", "endogenous", "adenylate", "kinase", "activity"], "h": {"id": "C0001497", "name": "C0001497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [6, 7]}}
{"token": ["The", "patients", "with", "C0032285#ent", "<e1>", "older", "and", "were", "more", "likely", "than", "those", "with", "C2349529#ent", "<e2>", "have", "predisposing", "factors", "acquisition", "of", "the", "infection", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2349529", "name": "C2349529#ent", "pos": [13, 14]}}
{"token": ["Most", "common", "in", "the", "C0239377#ent", "<e1>", "the", "consequences", "of", "iatrogenic", "arterial", "occlusion", "be", "C0017086#ent", "<e2>", "and", "limb", "loss"], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017086", "name": "C0017086#ent", "pos": [13, 14]}}
{"token": ["On", "the", "first", "admission", "to", "our", "hospital", "he", "showed", "C0007758#ent", "<e1>", ",", "loose", "of", "expressive", "language", "and", "C0206061#ent", "<e2>"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [17, 18]}}
{"token": ["We", "recently", "identified", "a", "novel", "C0079429#ent", "<e1>", "that", "causes", "C1412747#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412747", "name": "C1412747#ent", "pos": [9, 10]}}
{"token": ["With", "respect", "to", "intrafamiliar", "variations", "in", "the", "manifestation", "of", "BBS", ",", "we", "suggest", "that", "plasmolipin", "might", "be", "either", "another", "candidate", "C0079429#ent", "<e1>", "or", "a", "modifier", "of", "the", "C1412747#ent", "<e2>", "phenotype", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1412747", "name": "C1412747#ent", "pos": [27, 28]}}
{"token": ["Primary", "nephrectomy", "an", "adequate", "surgical", "intervention", "cases", "of", "a", "total", "destructive", "process", "the", "kidney", ",", "grave", "C0029166#ent", "<e1>", "and", "a", "toxic", "response", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "CGS", "9896", ",", "a", "partial", "benzodiazepine", "agonist", ",", "and", "C0008188#ent", "<e1>", ",", "a", "full", "C0005064#ent", "<e2>", "on", "stress-induced", "gastric", "ulcers", "as", "well", "as", "blood", "glucose", "compared", "."], "h": {"id": "C0008188", "name": "C0008188#ent", "pos": [12, 13]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [17, 18]}}
{"token": ["Inspection", "of", "MS/MS", "spectra", "components", "in", "the", "unknown", "library", "compared", "to", "the", "MS/MS", "spectrum", "a", "known", "standard", "(", "C0008188#ent", "<e1>", ")", "identified", "a", "subclass", "of", "C0005064#ent", "<e2>", "."], "h": {"id": "C0008188", "name": "C0008188#ent", "pos": [18, 19]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [25, 26]}}
{"token": ["We", "present", "a", "patient", "who", ",", "to", "our", "knowledge", ",", "is", "the", "first", "with", "C0032453#ent", "<e1>", "be", "treated", "successfully", "with", "C1639494#ent", "<e2>", "."], "h": {"id": "C0032453", "name": "C0032453#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [20, 21]}}
{"token": ["Three", "patients", "with", "C0032453#ent", "<e1>", "treated", "successfully", "with", "C1639494#ent", "<e2>", "."], "h": {"id": "C0032453", "name": "C0032453#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [8, 9]}}
{"token": ["Two", "types", "of", "hearts", "were", "studied", ":", "C1442837#ent", "<e1>", "induced", "by", "C0022245#ent", "<e2>", "(", "ISP", ")", "in", "rats", "and", "human", "hearts", "with", "early", "coagulation", "necrosis", "Early", "CN", "."], "h": {"id": "C1442837", "name": "C1442837#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [11, 12]}}
{"token": ["A", "dose-dependent", "effect", "as", "to", "enzyme", "values", "as", "well", "as", "to", "C1442837#ent", "<e1>", "observed", "24", "h", "after", "C0022245#ent", "<e2>", "application", "."], "h": {"id": "C1442837", "name": "C1442837#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [17, 18]}}
{"token": ["Genomic", "Southern-blot", "analysis", "the", "CDC2a", "and", "CDC2b", "cDNA", "probes", "that", "the", "A.", "thaliana", "genome", "contains", "several", "additional", "C0249586#ent", "<e1>", "which", "together", "with", "the", "CDC2a", "and", "CDC2b", "C1417679#ent", "<e2>", "may", "constitute", "a", "CDC2", "gene", "family"], "h": {"id": "C0249586", "name": "C0249586#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [26, 27]}}
{"token": ["Genes", "encoding", "dihydrofolate", "reductase", "thymidylate", "synthase", "serine", "hydroxymethyl", "transferase", "a", "C0249586#ent", "<e1>", "helicase", "ERCC6-like", "protein", "were", "each", "located", "on", "a", "single", "chromosome", "C1417679#ent", "<e2>", "for", "both", "beta-tubulin", "and", "aminopeptidase", "were", "on", "two", "different", "chromosomes", "."], "h": {"id": "C0249586", "name": "C0249586#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [22, 23]}}
{"token": ["Two", "novel", "genes", "were", "induced", ",", "as", "well", "as", "the", "C0079429#ent", "<e1>", "for", "ceruloplasmin", ",", "a", "C0007841#ent", "<e2>", "with", "antioxidant", "properties"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007841", "name": "C0007841#ent", "pos": [16, 17]}}
{"token": ["Nucleotide", "sequence", "analysis", "the", "transposon", "insertion", "site", "a", "nonoxidizing", "mutant", "revealed", "a", "C0079429#ent", "<e1>", "(", "designated", "cumA", ")", "encoding", "a", "protein", "homologous", "C0007841#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007841", "name": "C0007841#ent", "pos": [22, 23]}}
{"token": ["Aceruloplasminaemia", "is", "a", "rare", "recessive", "disorder", "by", "mutations", "in", "the", "C0079429#ent", "<e1>", "encoding", "the", "C0007841#ent", "<e2>", "thought", "to", "be", "involved", "in", "cellular", "iron", "export"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007841", "name": "C0007841#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "C1709289#ent", "<e1>", "counteracted", "the", "repressive", "effects", "glucocorticoids", "on", "C0162745#ent", "<e2>", "expression", "and", "restored", "collagenase", "mRNA", "levels", "."], "h": {"id": "C1709289", "name": "C1709289#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "C1709289#ent", "<e1>", "counteracted", "the", "repressive", "effects", "glucocorticoids", "on", "collagenase", "gene", "expression", "and", "restored", "C0162745#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C1709289", "name": "C1709289#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [16, 17]}}
{"token": ["These", "are", "principally", ":", "benign", "neonatal", "C3889476#ent", "<e1>", "benign", "neonatal", "convulsions", ",", "benign", "myoclonic", "epilepsy", "infancy", ",", "childhood", "absence", "C0014544#ent", "<e2>", ",", "juvenile", "absence", "C0014544#ent", "<e2>", ",", "juvenile", "myoclonic", "epilepsy", "C0014544#ent", "<e2>", "with", "generalised", "tonic-clonic", "seizures", "awakening", "."], "h": {"id": "C3889476", "name": "C3889476#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [19, 20]}}
{"token": ["C0146951#ent", "<e1>", "slightly", "changed", "enzyme", "sensitivity", "towards", "C0030557#ent", "<e2>", "and", "deprenyl", ",", "regardless", "of", "the", "preincubation", "time", "or", "the", "substrate", "used", "."], "h": {"id": "C0146951", "name": "C0146951#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030557", "name": "C0030557#ent", "pos": [7, 8]}}
{"token": ["Congenital", "hepatic", "fibrosis", "C0019099#ent", "<e1>", ")", "is", "a", "recognized", "cause", "of", "portal", "hypertension", "oesophageal", "varices", "gastro-intestinal", "haemorrhage", "C0008311#ent", "<e2>", "in", "children", "without", "significant", "impairment", "of", "hepatic", "or", "renal", "function"], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [17, 18]}}
{"token": ["To", "define", "the", "collagen-lowering", "potential", "of", "C1524095#ent", "<e1>", ",", "we", "have", "studied", "the", "effects", "of", "C1524095#ent", "<e1>", "on", "production", "of", "collagen-degrading", "proteases", "such", "as", "C2001899#ent", "<e1>", ",", "-9", "and", "urokinase", "in", "vitro"], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [24, 25]}}
{"token": ["Muscles", "from", "animals", "treated", "with", "C0017082#ent", "<e1>", "did", "not", "show", "the", "substantial", "depolarization", "of", "the", "resting", "membrane", "potential", "C1412063#ent", "<e2>", ")", "in", "K+-free", "solution", "(", "6", "h", ")", "shown", "by", "control", "muscles"], "h": {"id": "C0017082", "name": "C0017082#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412063", "name": "C1412063#ent", "pos": [18, 19]}}
{"token": ["This", "paper", "describes", "the", "methodology", "for", "the", "C1414174#ent", "<e1>", "survey", "in", "C1334103#ent", "<e2>", "detailing", "the", "preparation", "of", "materials", ",", "recruitment", "of", "physicians", ",", "data", "collection", "data", "management"], "h": {"id": "C1414174", "name": "C1414174#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334103", "name": "C1334103#ent", "pos": [11, 12]}}
{"token": ["These", "results", "provide", "direct", "evidence", "that", "premature", "expression", "C1332695#ent", "<e1>", "make", "cells", "more", "vulnerable", "to", "chemically-induced", "C1421313#ent", "<e2>", "of", "mitosis", "from", "the", "completion", "of", "DNA", "replication"], "h": {"id": "C1332695", "name": "C1332695#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421313", "name": "C1421313#ent", "pos": [16, 17]}}
{"token": ["We", "have", "also", "screened", "for", "mutations", "at", "the", "87A7", "heat", "shock", "locus", "using", "a", "chromosome", "that", "has", "only", "one", "copy", "of", "C0017337#ent", "<e1>", "encoding", "the", "70,000", "dalton", "C0063423#ent", "<e2>", "hsp70", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0063423", "name": "C0063423#ent", "pos": [27, 28]}}
{"token": ["Each", "treatment", "was", "applied", "in", "the", "morning", "with", "one", "shot", "(", "0.2", "mg", "C0724666#ent", "<e1>", "or", "0.1", "mg", "C0543495#ent", "<e2>", ")", "."], "h": {"id": "C0724666", "name": "C0724666#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [18, 19]}}
{"token": ["We", "describe", "the", "use", "of", "C0700481#ent", "<e1>", "to", "increase", "urine", "output", "a", "pediatric", "patient", "with", "sepsis", ",", "C0018802#ent", "<e2>", "oliguria", ",", "and", "volume", "overload"], "h": {"id": "C0700481", "name": "C0700481#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["The", "C0033607#ent", "<e1>", "fraction", "strongly", "suppresses", "the", "ATPase", "activity", "membrane", "bound", "C0001473#ent", "<e2>", "in", "a", "Mg(2+)-dependent", "manner", "and", "is", "cold", "and", "heat", "stable", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [11, 12]}}
{"token": ["The", "quantitative", "determinations", "of", "C0070570#ent", "<e1>", "in", "C0714690#ent", "<e2>", "USP", "and", "of", "C0070570#ent", "<e1>", "and", "resorcinol", "in", "phenol-resorcinol-boric", "acid", "solution", "by", "high-pressure", "liquid", "chromatography", "reported", "."], "h": {"id": "C0714690", "name": "C0714690#ent", "pos": [7, 8]}, "relation": "has_product_component", "t": {"id": "C0070570", "name": "C0070570#ent", "pos": [4, 5]}}
{"token": ["When", "these", "oligosaccharides", "were", "used", "as", "C0015278#ent", "<e1>", "was", "revealed", "that", "Lec23", "cells", "are", "specifically", "defective", "in", "C0061422#ent", "<e2>", "a", "deficiency", "not", "previously", "identified", "among", "mammalian", "cell", "glycosylation", "mutants", "."], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0061422", "name": "C0061422#ent", "pos": [17, 18]}}
{"token": ["The", "present", "study", "underlines", "the", "importance", "of", "sodium", "phenylacetate", "NaPA", ")", ",", "a", "C1254351#ent", "<e1>", "approved", "for", "urea", "cycle", "disorders", "in", "inhibiting", "the", "C0027721#ent", "<e2>", "adoptively", "transferred", "EAE", "in", "female", "SJL/J", "mice", "at", "multiple", "steps"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [23, 24]}}
{"token": ["Since", "certain", "lipophilic", "statins", "i.e.", "simvastatin", ",", "C0286651#ent", "<e1>", ",", "lovastatin", ")", "are", "a", "substrate", "of", "C1142644#ent", "<e2>", ",", "we", "were", "interested", "in", "potential", "drug", "interactions", "clopidogrel", "and", "statins", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [7, 8]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [16, 17]}}
{"token": ["C0286651#ent", "<e1>", "is", "also", "metabolised", "by", "C1142644#ent", "<e2>", ",", "in", "vitro", "atorvastatin", "inhibits", "the", "cytochrome", "P450", "metabolism", "of", "mexazolam", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "DIM", "increased", "the", "expression", "of", "NAG-1", "as", "well", "as", "C1412616#ent", "<e1>", "C3542399#ent", "<e2>", ")", ",", "and", "the", "induction", "of", "C3542399#ent", "<e2>", "was", "earlier", "than", "that", "of", "NAG-1", "."], "h": {"id": "C1412616", "name": "C1412616#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3542399", "name": "C3542399#ent", "pos": [14, 15]}}
{"token": ["The", "insulin-like", "growth", "factor-I", "receptor", "IGF-IR", ")", ",", "C1416655#ent", "<e1>", ",", "vascular", "endothelial", "growth", "factor", "receptor", "VEGFR", ")", "and", "C1414313#ent", "<e2>", "EGFR", ")", "have", "been", "identified", "as", "potential", "drug", "targets", "SCLC", "."], "h": {"id": "C1416655", "name": "C1416655#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [19, 20]}}
{"token": ["A", "second", "progenitor", ",", "referred", "to", "as", "SCF/transforming", "growth", "factor-alpha", "progenitor", "coexpresses", "C1416655#ent", "<e1>", "and", "the", "avian", "C1414313#ent", "<e2>", "These", "progenitors", "undergo", "sustained", "self-renewal", "when", "grown", "in", "the", "presence", "of", "transforming", "growth", "factor-alpha", "plus", "estradiol", "."], "h": {"id": "C1416655", "name": "C1416655#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [17, 18]}}
{"token": ["This", "study", "compared", "the", "expression", "and", "activity", "of", "C2717970#ent", "<e1>", "their", "inhibitors", "in", "C0519097#ent", "<e2>", "their", "expression", "in", "the", "aortic", "wall", "patients", "with", "aortic", "occlusive", "disease", "AOD", ")", "."], "h": {"id": "C2717970", "name": "C2717970#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0519097", "name": "C0519097#ent", "pos": [13, 14]}}
{"token": ["Therefore", ",", "the", "present", "study", "was", "performed", "to", "compare", "ergonovine", "responsiveness", "both", "clinical", "and", "ambulatory", "electrocardiographic", "activity", "patients", "with", "C0002963#ent", "<e1>", "long-term", "therapy", "with", "placebo", ",", "C0042523#ent", "<e2>", ",", "and", "nifedipine", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [26, 27]}}
{"token": ["For", "patients", "with", "C0002963#ent", "<e1>", "diltiazem", ",", "nifedipine", "and", "C0042523#ent", "<e2>", "are", "extremely", "effective", "in", "preventing", "episodes", "of", "coronary", "vasospasm", "symptoms", "of", "ischemia", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [9, 10]}}
{"token": ["As", "thalidomide", "is", "an", "effective", "treatment", "for", "C1334513#ent", "<e1>", ",", "this", "study", "assessed", "the", "effect", "of", "this", "C0013227#ent", "<e2>", "on", "these", "phenomena", "."], "h": {"id": "C1334513", "name": "C1334513#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["Additional", "data", "quickly", "confirmed", "thalidomide", "'s", "efficacy", "in", "C1334513#ent", "<e1>", ",", "and", "today", "it", "is", "the", "C0013227#ent", "<e2>", "of", "choice", "in", "the", "condition", "."], "h": {"id": "C1334513", "name": "C1334513#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [16, 17]}}
{"token": ["Increased", "oxidative", "stress", "C0947751#ent", "<e1>", "been", "shown", "in", "patients", "with", "cardiac", "syndrome", "X", "C3538707#ent", "<e2>", ";", "angina", ",", "exercise-induced", "ischemia", "and", "normal", "coronary", "angiogram", "."], "h": {"id": "C0947751", "name": "C0947751#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538707", "name": "C3538707#ent", "pos": [13, 14]}}
{"token": ["Ubiquitin", "and", "C1540159#ent", "<e1>", "27", "expression", "was", "also", "restricted", "to", "abnormal", "neurons", "of", "C0236642#ent", "<e2>", "CJD", ",", "but", "the", "proportion", "of", "stained", "cells", "less", "than", "that", "expressing", "alpha", "B-crystallin"], "h": {"id": "C1540159", "name": "C1540159#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0236642", "name": "C0236642#ent", "pos": [13, 14]}}
{"token": ["C0019693#ent", "<e1>", "be", "associated", "with", "types", "of", "C0152087#ent", "<e2>", "which", "are", "often", "underdiagnosed", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0152087", "name": "C0152087#ent", "pos": [7, 8]}}
{"token": ["Rotational", "behavior", "response", "to", "different", "C0035064#ent", "<e1>", ",", "and", "the", "levels", "of", "C1414052#ent", "<e2>", "and", "D1", "dopamine", "receptors", "C1414052#ent", "<e2>", "and", "D1", "dopamine", "receptor", "mRNAs", "in", "corpus", "striatum", "then", "measured", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [12, 13]}}
{"token": ["C0340968#ent", "<e1>", "a", "rare", "cause", "of", "C1387532#ent", "<e2>", ",", "in", "its", "most", "severe", "form", ",", "requires", "splenectomy", "in", "childhood", "."], "h": {"id": "C0340968", "name": "C0340968#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C1387532", "name": "C1387532#ent", "pos": [6, 7]}}
{"token": ["If", "mucociliary", "clearance", "can", "be", "stimulated", "sufficiently", "from", "an", "early", "age", "then", "there", "is", "the", "possibility", "that", "secondary", "C0024118#ent", "<e1>", "be", "eradicated", "from", "the", "syndrome", "of", "C0012634#ent", "<e2>"], "h": {"id": "C0024118", "name": "C0024118#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [26, 27]}}
{"token": ["The", "location", "of", "circadian", "clock", "cells", "monarch", "brain", "has", "been", "identified", "in", "the", "dorsolateral", "protocerebrum", "(", "pars", "lateralis", ";", "these", "cells", "express", "PERIOD", ",", "C1420737#ent", "<e1>", ",", "and", "a", "Drosophila-like", "cryptochrome", "designated", "C1418965#ent", "<e2>", "."], "h": {"id": "C1420737", "name": "C1420737#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1418965", "name": "C1418965#ent", "pos": [32, 33]}}
{"token": ["Several", "cases", "of", "C0009319#ent", "<e1>", "induced", "by", "non-steroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e2>", ")", "have", "been", "reported", "but", "the", "general", "role", "of", "recent", "NSAID", "intake", "as", "a", "risk", "factor", "acute", "diarrhoea", "not", "been", "studied", "to", "date", "."], "h": {"id": "C0009319", "name": "C0009319#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}}
{"token": ["The", "P.", "aeruginosa", "C0632027#ent", "<e1>", "is", "homologous", "with", "mammalian", "C0632027#ent", "<e1>", ",", "C1420870#ent", "<e1>", "and", "tyrosine", "hydroxylase"], "h": {"id": "C0632027", "name": "C0632027#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [12, 13]}}
{"token": ["Betaine-homocysteine", "methyltransferase", "C1530585#ent", "<e1>", ")", "serves", ",", "next", "to", "C3713294#ent", "<e2>", "as", "a", "facilitator", "of", "methyl", "group", "donation", "remethylation", "of", "homocysteine", "into", "methionine", ",", "and", "reduced", "functioning", "of", "C1530585#ent", "<e1>", "could", "theoretically", "result", "in", "elevated", "homocysteine", "levels"], "h": {"id": "C1530585", "name": "C1530585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3713294", "name": "C3713294#ent", "pos": [9, 10]}}
{"token": ["Synthetic", "oligonucleotides", "designed", "to", "discriminate", "between", "C1412481#ent", "<e1>", "alleles", "epsilon", "3", "and", "C0052201#ent", "<e2>", "enabled", "us", "to", "distinguish", "heterozygous", "carriers", "in", "a", "hybridization", "assay"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0052201", "name": "C0052201#ent", "pos": [12, 13]}}
{"token": ["Individuals", "were", "grouped", "according", "to", "C1412481#ent", "<e1>", "genotype", "(", "C0052201#ent", "<e2>", "versus", "C0052201#ent", "<e2>", ")", ",", "matched", "on", "age", "and", "education", ",", "and", "their", "Total", "span", "Primacy", "scores", "were", "compared", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0052201", "name": "C0052201#ent", "pos": [9, 10]}}
{"token": ["C0023892#ent", "<e1>", "an", "uncommon", "finding", "in", "infants", "with", "C0010674#ent", "<e2>", "but", "it", "is", "present", "in", "more", "than", "a", "fifth", "of", "surviving", "children", "and", "adolescents", "."], "h": {"id": "C0023892", "name": "C0023892#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [8, 9]}}
{"token": ["C0023892#ent", "<e1>", "significant", "morbidity", "and", "mortality", "in", "C0010674#ent", "<e2>", "CF", ")", "."], "h": {"id": "C0023892", "name": "C0023892#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [7, 8]}}
{"token": ["These", "chromatin", "modifications", "principally", "through", "the", "Rpd3S", "complex", "to", "aid", "glucose", "repression", "C1416829#ent", "<e1>", "-", "10", "at", "physiologically", "relevant", "C0242209#ent", "<e2>", "concentrations", "."], "h": {"id": "C1416829", "name": "C1416829#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242209", "name": "C0242209#ent", "pos": [19, 20]}}
{"token": ["We", "tested", "monoclonal", "IgM", "and", "asialo-GM1", "antibodies", "from", "6", "patients", "with", "C0442874#ent", "<e1>", "binding", "to", "lipopolysaccharides", "(", "C0175697#ent", "<e2>", ")", "from", "three", "stains", "of", "Campylobacter", "jejuni"], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [17, 18]}}
{"token": ["However", ",", "increased", "intracellular", "calcium", "after", "drug", "treatment", "hypoxia", "suggests", "a", "potential", "mechanism", "for", "these", "drugs", "in", "C1801950#ent", "<e1>", "protection", ";", "C0028066#ent", "<e2>", "and", "SKF-96365", "plus", "hypoxic", "stress", "trigger", "calcium-mediated", "signaling", "cascades", "altering", "C1801950#ent", "<e1>", "integrity", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1801950", "name": "C1801950#ent", "pos": [17, 18]}}
{"token": ["In", "addition", "to", "C1415852#ent", "<e1>", ",", "PR", "and", "other", "defence-related", "genes", "are", "C0907533#ent", "<e2>", "expressed", "in", "cie1", "plants", "."], "h": {"id": "C1415852", "name": "C1415852#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [12, 13]}}
{"token": ["The", "reduction", "in", "number", "and", "C0720099#ent", "<e1>", "of", "episodes", "was", "similar", "for", "C0239377#ent", "<e2>", "and", "painless", "episodes", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [12, 13]}}
{"token": ["Purified", "poloxamer", "188", "may", "increase", "tissue", "oxygenation", "thereby", "reduce", "inflammation", ",", "pain", ",", "and", "the", "overall", "C0720099#ent", "<e1>", "of", "such", "C0239377#ent", "<e2>", "episodes", "in", "patients", "with", "SCD", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [20, 21]}}
{"token": ["Most", "C0280950#ent", "<e1>", "E3s", "regulate", "the", "cell", "cycle", "p53", ",", "transcription", ",", "C1333237#ent", "<e2>", "cell", "signaling", "or", "apoptosis", "."], "h": {"id": "C0280950", "name": "C0280950#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [12, 13]}}
{"token": ["Differential", "scanning", "calorimetry", "DSC", ")", ",", "polarizing", "microscopy", "X-ray", "diffraction", "studies", "been", "performed", "on", "dry", "and", "C0008161#ent", "<e1>", "natural", "bovine", "brain", "C0007804#ent", "<e2>", "."], "h": {"id": "C0008161", "name": "C0008161#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [21, 22]}}
{"token": ["The", "pharmacokinetics", "of", "antipyrine", "(", "C0002586#ent", "<e1>", ")", "in", "3", "species", "of", "C1334981#ent", "<e2>", "been", "evaluated", "following", "its", "intravenous", "administration", "a", "dose", "level", "of", "92", "mg/kg", "."], "h": {"id": "C0002586", "name": "C0002586#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334981", "name": "C1334981#ent", "pos": [12, 13]}}
{"token": ["Originally", "used", "to", "treat", "C0033860#ent", "<e1>", "nearly", "three", "decades", "ago", ",", "mycophenolic", "acid", "reformulated", "as", "C0209368#ent", "<e2>", "MMF", ")", ",", "has", "been", "rediscovered", "by", "the", "world", "of", "dermatology", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0209368", "name": "C0209368#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "C1442872#ent", "<e1>", "acting", "mode", "of", "C0051561#ent", "<e2>", "in", "human", "pathogenic", "yeast", "Candida", "albicans"], "h": {"id": "C1442872", "name": "C1442872#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0051561", "name": "C0051561#ent", "pos": [12, 13]}}
{"token": ["The", "clinical", "efficacy", "the", "two", "C1874237#ent", "<e1>", "ketoprofen", "hydroalcoholic", "gel", "(", "C0764719#ent", "<e2>", "and", "diclofenac", "emulgel", ",", "for", "osteoarthritis", "of", "the", "knee", "was", "studied", "."], "h": {"id": "C1874237", "name": "C1874237#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0764719", "name": "C0764719#ent", "pos": [11, 12]}}
{"token": ["600", "mg", "C0039771#ent", "<e1>", "(", "Euspirax", ")", "and", "350", "mg", "C0002575#ent", "<e2>", "(", "Euphyllin", "retard", "."], "h": {"id": "C0039771", "name": "C0039771#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [10, 11]}}
{"token": ["While", "the", "C0039771#ent", "<e1>", "a", "slower", "absorption", "rate", "than", "the", "capsule", "or", "the", "C0002575#ent", "<e2>", "all", "three", "products", "appeared", "to", "be", "completely", "bioavailable", "."], "h": {"id": "C0039771", "name": "C0039771#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [13, 14]}}
{"token": ["ii", ")", "Clemastine", ",", "used", "as", "an", "C0019592#ent", "<e1>", ",", "was", "as", "effective", "as", "C0771004#ent", "<e2>", "on", "the", "metabolic", "bursts", "of", "leukocytes", ",", "including", "changes", "of", "membrane", "potential", "in", "leukocytes", "."], "h": {"id": "C0019592", "name": "C0019592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0771004", "name": "C0771004#ent", "pos": [14, 15]}}
{"token": ["Eye", "movement", "abnormalities", "familial", "mental", "retardation", "syndrome", "lead", "to", "the", "suspicion", "of", "a", "storage", "disorder", "including", "C0220756#ent", "<e1>", "Gaucher's", "disease", "abetalipoproteinemia", "and", "C0019202#ent", "<e2>"], "h": {"id": "C0220756", "name": "C0220756#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [22, 23]}}
{"token": ["Two", "patients", "presented", "with", "C0878544#ent", "<e1>", "induced", "by", "C0025289#ent", "<e2>", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [8, 9]}}
{"token": ["C0878544#ent", "<e1>", "cerebrovascular", "disease", "common", ",", "but", "rare", "with", "C0025289#ent", "<e2>", ",", "which", "needs", "intensive", "care", "of", "the", "risk", "of", "respiratory", "arrest"], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [9, 10]}}
{"token": ["One", "hundred", "seven", "patients", "(", "93", "women", "and", "14", "men", ")", "over", "age", "55", "yr", "with", "C0271790#ent", "<e1>", "no", "previous", "history", "of", "C0040128#ent", "<e2>", "prospectively", "studied", "."], "h": {"id": "C0271790", "name": "C0271790#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [22, 23]}}
{"token": ["C0018606#ent", "<e1>", "(", "HHT", ")", "is", "one", "of", "several", "cephalotaxine", "C0949738#ent", "<e2>", "that", "has", "shown", "clinical", "efficacy", "patients", "with", "acute", "myelogenous", "leukemia", "AML", ")", "."], "h": {"id": "C0018606", "name": "C0018606#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0949738", "name": "C0949738#ent", "pos": [10, 11]}}
{"token": ["Given", "that", "C0399440#ent", "<e1>", "plays", "a", "critical", "role", "in", "differentiation", "of", "hepatic", "stem", "cells", "overexpression", "of", "C0399440#ent", "<e1>", "acts", "on", "off-balanced", "cell", "fate", "determination", "in", "C2697827#ent", "<e1>", "patients", "."], "h": {"id": "C0399440", "name": "C0399440#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2697827", "name": "C2697827#ent", "pos": [25, 26]}}
{"token": ["We", "had", "previously", "reported", "that", "bilateral", "destruction", "of", "the", "medial", "C1418482#ent", "<e1>", "seriously", "compromises", "the", "development", "of", "discriminative", "heart", "rate", "C0010278#ent", "<e2>", "in", "the", "rabbit", "."], "h": {"id": "C1418482", "name": "C1418482#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [20, 21]}}
{"token": ["C0040412#ent", "<e1>", "the", "central", "parts", "the", "palate", "and", "C1846919#ent", "<e2>", "or", "cheek", "pressure", "the", "vestibular", "flange", "to", "be", "of", "less", "importance", "."], "h": {"id": "C0040412", "name": "C0040412#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1846919", "name": "C1846919#ent", "pos": [8, 9]}}
{"token": ["Neutral", "endopeptidase", "24.11", "C3887624#ent", "<e1>", "NEP", ")", "is", "a", "C1366499#ent", "<e2>", "a", "catalytic", "activity", "a", "specificity", "very", "similar", "to", "that", "of", "thermolysin", ",", "a", "bacterial", "zinc-endoprotease", "."], "h": {"id": "C3887624", "name": "C3887624#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366499", "name": "C1366499#ent", "pos": [9, 10]}}
{"token": ["C1412332#ent", "<e1>", ",", "an", "abundant", "plasma", "protein", "C0536221#ent", "<e2>", "is", "mainly", "synthesized", "in", "the", "liver", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [7, 8]}}
{"token": ["In", "this", "report", ",", "the", "C2744579#ent", "<e1>", "and", "ADP", "C0033993#ent", "<e2>", "ectonucleotidases", "of", "chicken", "gizzard", "smooth", "muscle", "liver", "plasma", "membranes", "were", "studied", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [9, 10]}}
{"token": ["Murine", "C1333668#ent", "<e1>", "stimulated", "thymidine", "incorporation", "by", "granulosa", "cells", "oGDF9", "and", "C1332423#ent", "<e2>", "alone", "had", "no", "effect"], "h": {"id": "C1333668", "name": "C1333668#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332423", "name": "C1332423#ent", "pos": [11, 12]}}
{"token": ["The", "oocyte-secreted", "polypeptide", "growth", "factors", ",", "growth", "differentiation", "factor", "9", "C1333668#ent", "<e1>", ")", "and", "bone", "morphogenetic", "protein", "15", "BMP15", ",", "also", "known", "as", "C1332423#ent", "<e2>", ")", "have", "both", "been", "shown", "to", "be", "essential", "for", "ovarian", "follicular", "growth", "function", "."], "h": {"id": "C1333668", "name": "C1333668#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332423", "name": "C1332423#ent", "pos": [23, 24]}}
{"token": ["Because", "the", "C0042402#ent", "<e1>", "exogenous", "LTB4", "was", "not", "altered", "by", "C0003211#ent", "<e2>", "injected", "locally", "or", "taken", "orally", ",", "we", "suggest", "that", "endogenous", "prostaglandins", "are", "not", "involved", "in", "this", "response", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [10, 11]}}
{"token": ["This", "article", "compares", "various", "skeletal", "muscle", "C0042402#ent", "<e1>", ",", "addresses", "issues", "related", "to", "C0003211#ent", "<e2>", "provides", "an", "algorithm", "for", "acute", "pain", "management", "an", "injured", "worker", ",", "and", "discusses", "topical", "medications", "the", "treatment", "of", "pain", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "whether", "C0009450#ent", "<e1>", "with", "HIV", "affects", "the", "synthesis", "of", "C3540579#ent", "<e2>", "and", "Th2", "cytokines", "by", "peripheral", "blood", "T", "cells", "women", "infected", "with", "human", "papillomavirus", "HPV", ")", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [17, 18]}}
{"token": ["Hereafter", "the", "C0004960#ent", "<e1>", "was", "withdrawn", "and", "group", "2", "the", "regular", "training", "with", "C0700349#ent", "<e2>", "solely", "vis-a-vis", "saline", "."], "h": {"id": "C0004960", "name": "C0004960#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700349", "name": "C0700349#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "the", "pattern", "of", "early", "childhood", "C0036572#ent", "<e1>", "within", "a", "family", "with", "autosomal", "dominant", "chondrocalcinosis", "C4049873#ent", "<e2>", ",", "which", "causes", "adult-onset", "arthritis", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4049873", "name": "C4049873#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "with", "C0009324#ent", "<e1>", "U.C.", ")", ",", "there", "was", "significant", "high", "levels", "of", "C1706005#ent", "<e2>", "and", "IgE.", "IgD", "significant", "low", "level", ",", "while", "IgG", "and", "IgA", "showed", "no", "change"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [14, 15]}}
{"token": ["Incubation", "of", "chondrocytes", "with", "diacerhein", "for", "24", "hours", "was", "not", "associated", "with", "changes", "in", "C3536869#ent", "<e1>", "or", "collagen", "production", "but", "substantially", "antagonized", "interleukin-1-mediated", "enhancement", "of", "C0962754#ent", "<e2>", "production", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [25, 26]}}
{"token": ["The", "administration", "of", "DA", "(", "100", "mg/kg", "dose", ")", "and", "C0034665#ent", "<e1>", "reversed", "the", "activities", "of", "iNOS", "and", "C1332390#ent", "<e2>", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332390", "name": "C1332390#ent", "pos": [18, 19]}}
{"token": ["Sec24D", "is", "cloned", "by", "screening", "a", "human", "pancreas", "of", "cDNA", "library", "an", "expressed", "sequence", "tag", "EST", ")", "fragment", "that", "is", "C1334043#ent", "<e1>", "to", ",", "but", "distinct", "from", ",", "C1419927#ent", "<e2>", "and", "Sec24B", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1419927", "name": "C1419927#ent", "pos": [28, 29]}}
{"token": ["The", "ketogenic", "diet", "C1839259#ent", "<e1>", ")", "is", "a", "broadly", "effective", "treatment", "for", "medically", "refractory", "C0014544#ent", "<e2>", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [14, 15]}}
{"token": ["In", "two", "sets", "of", "backcross", "progeny", "originating", "from", "parental", "strains", "with", "different", "C0002085#ent", "<e1>", ",", "no", "close", "linkage", "was", "found", "between", "the", "C1367482#ent", "<e2>", "locus", "and", "17", "other", "loci", "tested", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1367482", "name": "C1367482#ent", "pos": [22, 23]}}
{"token": ["Thirty-eight", "tagging", "SNPs", "in", "six", "C1417679#ent", "<e1>", "(", "INHA", ",", "INHBA", ",", "INHBB", ",", "C1416438#ent", "<e2>", ",", "INHBE", ",", "and", "SMAD4", ")", "were", "genotyped", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416438", "name": "C1416438#ent", "pos": [14, 15]}}
{"token": ["Determination", "of", "the", "activity", "of", "C0673071#ent", "<e1>", "revealed", "that", "0.3", "and", "3", "mM", "C0812384#ent", "<e2>", "inhibited", "the", "phosphodiesterase", "activity", "dog", "coronary", "artery", "human", "atrial", "tissues", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0673071", "name": "C0673071#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812384", "name": "C0812384#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "C0005099#ent", "<e1>", "was", "a", "substrate", "for", "human", "FMO1", ",", "FMO3", ",", "C1414646#ent", "<e2>", "and", "FMO5", "."], "h": {"id": "C0005099", "name": "C0005099#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414646", "name": "C1414646#ent", "pos": [14, 15]}}
{"token": ["The", "recently", "identified", "ceramide", "transfer", "protein", "C2983797#ent", "<e1>", ",", "is", "responsible", "for", "the", "bulk", "of", "C1413584#ent", "<e2>", "the", "endoplasmic", "reticulum", "ER", ")", "to", "the", "Golgi", "."], "h": {"id": "C2983797", "name": "C2983797#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413584", "name": "C1413584#ent", "pos": [15, 16]}}
{"token": ["However", ",", "C1419420#ent", "<e1>", "-", "1", "pre4", "-", "1", "double", "mutants", "showed", "enhanced", "C0003762#ent", "<e2>", "sensitivity", "and", "increased", "accumulation", "of", "ubiquitin", "protein", "conjugates", ",", "as", "compared", "with", "C1419420#ent", "<e1>", "-", "1", "single", "mutants", "."], "h": {"id": "C1419420", "name": "C1419420#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003762", "name": "C0003762#ent", "pos": [13, 14]}}
{"token": ["Human", "C0913413#ent", "<e1>", ",", "a", "novel", "serine/threonine", "kinase", "is", "a", "member", "of", "the", "C0031727#ent", "<e2>", "includes", "the", "Drosophila", "tumour", "suppressor", "lats/warts"], "h": {"id": "C0913413", "name": "C0913413#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "anatomical", "and", "functional", "imaging", "studies", "indicate", "that", "the", "primate", "cholinergic", "system", "modulated", "by", "C2936882#ent", "<e1>", ",", "and", "pharmacological", "studies", "that", "C2936882#ent", "<e1>", "uses", "C1332758#ent", "<e1>", "influence", "visuospatial", "attention", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332758", "name": "C1332758#ent", "pos": [26, 27]}}
{"token": ["These", "P19[MyoD", "]", "cells", "continued", "to", "express", "markers", "characteristic", "of", "undifferentiated", "stem", "cells", "also", "expressed", "myf-5", "and", "the", "C0216045#ent", "<e1>", "transcripts", "normally", "present", "in", "myoblasts", "but", "absent", "from", "C1423526#ent", "<e2>"], "h": {"id": "C0216045", "name": "C0216045#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1423526", "name": "C1423526#ent", "pos": [28, 29]}}
{"token": ["By", "inhibiting", "prostanoid", "biosynthesis", "C0007710#ent", "<e1>", "selectively", "increased", "resistance", "in", "C0012634#ent", "<e2>", "lung", "at", "FIO2", "0.21", "and", "lowered", "shunt", "flow"], "h": {"id": "C0007710", "name": "C0007710#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["The", "clinical", "lesions", "this", "C1848862#ent", "<e1>", "vary", "from", "C0332573#ent", "<e2>", "annular", "superficial", "erosions", "and", "flaccid", "pustules"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0332573", "name": "C0332573#ent", "pos": [8, 9]}}
{"token": ["The", "clinical", "signs", "this", "C1848862#ent", "<e1>", "of", "presumed", "ocular", "histoplasmosis", ":", "C0332573#ent", "<e2>", "subretinian", "hemorrhages", "detachment", "of", "the", "retinal", "neurosensorial", "layer", ",", "presence", "of", "disseminated", "choroiditis", "scars", "and", "subretinian", "neovascularization", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0332573", "name": "C0332573#ent", "pos": [11, 12]}}
{"token": ["A", "patient", "is", "presented", "who", "developed", "a", "granulomatous", "hepatitis", "C0008033#ent", "<e1>", "approximately", "7", "months", "after", "an", "ileal", "bypass", "procedure", "for", "C0028756#ent", "<e2>"], "h": {"id": "C0008033", "name": "C0008033#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028756", "name": "C0028756#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "we", "also", "found", "that", "C1826646#ent", "<e1>", "and", "LY294002", ",", "but", "not", "PD98059", "inhibit", "the", "C1419034#ent", "<e2>", "promoter", "activity"], "h": {"id": "C1826646", "name": "C1826646#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419034", "name": "C1419034#ent", "pos": [16, 17]}}
{"token": ["Patients", "in", "the", "C0072857#ent", "<e1>", "group", "were", "less", "likely", "to", "have", "worsening", "C0018802#ent", "<e2>", "to", "be", "admitted", "to", "hospital", "but", "these", "changes", "were", "not", "statistically", "significant"], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}}
{"token": ["The", "pharmacokinetics", "of", "quinapril", "and", "its", "active", "metabolite", "C0072857#ent", "<e1>", "were", "studied", "in", "12", "patients", "with", "congestive", "heart", "failure", "C0018802#ent", "<e2>", ")", "after", "multiple", "oral", "doses", "10", "mg", "quinapril", "twice", "daily", "."], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [19, 20]}}
{"token": ["Restoration", "of", "intrarenal", "hemodynamics", "to", "or", "toward", "normal", "with", "C0072857#ent", "<e1>", "supports", "an", "important", "pathophysiological", "role", "of", "renin-angiotensin", "system", "this", "C0018802#ent", "<e2>", "."], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["Since", "only", "one", "of", "these", "sites", "is", "phosphorylated", "by", "C1956039#ent", "<e1>", "activation", "of", "C1420718#ent", "<e2>", "56", "mM", "K+", "may", "involve", "phosphorylation", "by", "multiple", "protein", "kinases", "rat", "pheochromocytoma", "PC12", "cells"], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [13, 14]}}
{"token": ["C1956039#ent", "<e1>", "1", "mol", "of", "phosphate/61,000-Da", "subunit", "of", "C1420718#ent", "<e2>", "and", "concomitantly", "decreases", "the", "apparent", "Km", "of", "the", "enzyme", "for", "cofactor", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [8, 9]}}
{"token": ["It", "is", "not", "known", "whether", "patients", "with", "isolated", "polycystic", "liver", "disease", "at", "an", "increased", "risk", "for", "developing", "C0007766#ent", "<e1>", "similar", "to", "patients", "with", "C3149841#ent", "<e2>"], "h": {"id": "C0007766", "name": "C0007766#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [23, 24]}}
{"token": ["C0007766#ent", "<e1>", "ICA", ")", "are", "a", "known", "extrarenal", "manifestation", "autosomal", "dominant", "C3149841#ent", "<e2>", "ADPKD", ")", "."], "h": {"id": "C0007766", "name": "C0007766#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [11, 12]}}
{"token": ["At", "this", "time", "64.3", "%", "of", "the", "C0031978#ent", "<e1>", "patients", "and", "73.4", "%", "of", "the", "patients", "on", "C0008783#ent", "<e2>", "had", "the", "ulcer", "healed"], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [17, 18]}}
{"token": ["Maximum", "responses", "C0001492#ent", "<e1>", "F-", ",", "guanosine", "5'-o-(3-thiotriphosphate", "and", "forskolin", "were", "greater", "in", "C1539322#ent", "<e2>", "than", "in", "EC", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [13, 14]}}
{"token": ["Thalidomide", "(", "400", "mg", ")", "was", "orally", "administered", "to", "6", "men", ",", "and", "their", "blood", "was", "stimulated", "ex", "vivo", "C0175697#ent", "<e1>", ",", "staphylococcal", "or", "mycobacterial", "antigens", "or", "antibody", "to", "CD3", "or", "C1332802#ent", "<e2>"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1332802", "name": "C1332802#ent", "pos": [31, 32]}}
{"token": ["Fluconazole", "therapy", "was", "started", "for", "C0006849#ent", "<e1>", "day", "112", ",", "but", "she", "complained", "of", "C0018681#ent", "<e2>", "soon", "after", "."], "h": {"id": "C0006849", "name": "C0006849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [14, 15]}}
{"token": ["A", "detailed", "characterization", "of", "Rga1", ",", "Rga2", ",", "and", "C1427201#ent", "<e1>", "suggested", "that", "they", "regulate", "different", "subsets", "of", "C1366537#ent", "<e2>", "function", "."], "h": {"id": "C1427201", "name": "C1427201#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366537", "name": "C1366537#ent", "pos": [18, 19]}}
{"token": ["Clinical", "manifestations", "C0423673#ent", "<e1>", ",", "paraparesia", "with", "pain", "and", "C0392699#ent", "<e2>", "in", "both", "lower", "extremities"], "h": {"id": "C0423673", "name": "C0423673#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0392699", "name": "C0392699#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "the", "effect", "of", "mental", "practice", "the", "learning", "of", "a", "sequential", "C1416596#ent", "<e1>", "for", "the", "lower", "limb", "in", "a", "patient", "with", "a", "C0018989#ent", "<e2>", "resulting", "from", "a", "stroke", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [23, 24]}}
{"token": ["Hydrolytic", "enzymes", "acid", "protease", "C3265462#ent", "<e1>", ",", "phosphodiesterase", ",", "RNAase", ",", "phytase", "and", "C3539583#ent", "<e2>", ")", "were", "present", "in", "the", "isolated", "vacuoles", "in", "amounts", "indicating", "a", "primarily", "vacuolar", "localization", "in", "vivo"], "h": {"id": "C3265462", "name": "C3265462#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539583", "name": "C3539583#ent", "pos": [13, 14]}}
{"token": ["We", "sought", "to", "analyze", "the", "degree", "of", "concordance", "between", "management", "and", "treatment", "decisions", "C0520679#ent", "<e1>", "patients", "at", "sleep", "reference", "centers", "(", "C2699119#ent", "<e2>", ")", "and", "at", "non-RCs", "(", "NRCs", ")", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2699119", "name": "C2699119#ent", "pos": [21, 22]}}
{"token": ["Activation", "of", "eosinophils", "with", "PAF", "or", "C5a", "induced", "a", "small", "but", "significant", "increase", "in", "the", "level", "of", "C1706333#ent", "<e1>", "expression", "on", "the", "C0014457#ent", "<e2>", "surface", "."], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [22, 23]}}
{"token": ["mAbs", "to", "L-selectin", "and", "VLA-4", "alpha", "but", "not", "C1706333#ent", "<e1>", ",", "significantly", "inhibited", "C0014457#ent", "<e2>", "rolling", "in", "vivo"], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [13, 14]}}
{"token": ["Its", "combination", "with", "C0055723#ent", "<e1>", "has", "the", "potential", "to", "prevent", "the", "C0022658#ent", "<e2>", "progression", "almost", "completely", "."], "h": {"id": "C0055723", "name": "C0055723#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [11, 12]}}
{"token": ["The", "number", "of", "single", "synapses", "was", "not", "different", "between", "the", "two", "groups", "but", "C0011175#ent", "<e1>", "more", "multiple", "synapses", "per", "C0702216#ent", "<e2>", "(", "23", ")", "than", "controls", "(", "6", ")", "."], "h": {"id": "C0011175", "name": "C0011175#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0702216", "name": "C0702216#ent", "pos": [19, 20]}}
{"token": ["Recently", ",", "C0044602#ent", "<e1>", "PI", "3-kinase", "has", "been", "implicated", "in", "the", "costimulatory", "function", "C1332802#ent", "<e2>", "by", "virtue", "of", "its", "ability", "to", "bind", "to", "a", "pYMNM", "motif", "within", "the", "cytoplasmic", "tail", "the", "antigen", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332802", "name": "C1332802#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "after", "C1332802#ent", "<e1>", "stimulation", ",", "the", "p85", "subunit", "C0044602#ent", "<e2>", "C0044602#ent", "<e2>", "activity", "were", "found", "in", "C1332802#ent", "<e1>", "immunoprecipitates", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332802", "name": "C1332802#ent", "pos": [4, 5]}}
{"token": ["In", "contrast", ",", "C0044602#ent", "<e1>", "not", "alter", "C1332802#ent", "<e2>", "or", "CD3", "cross-linking", "LCK-induced", "EMT", "phosphorylation", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332802", "name": "C1332802#ent", "pos": [7, 8]}}
{"token": ["Physiologic", "and", "histologic", "changes", "were", "studied", "in", "addition", "to", "TGF-beta1", "mRNA", "and", "protein", "expressions", "and", "mRNA", "expression", "of", "plasminogen", "activator", "inhibitor-1", "C1705527#ent", "<e1>", ")", "and", "the", "extracellular", "matrix", "ECM", ")", "proteins", "C1412792#ent", "<e2>", "and", "types", "I", "IV", "collagen"], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1412792", "name": "C1412792#ent", "pos": [31, 32]}}
{"token": ["Erythropoietin", "concentrations", "in", "serum", "samples", "from", "patients", "with", "Fanconi's", "C0002874#ent", "<e1>", "to", "be", "greater", "than", "in", "samples", "from", "patients", "with", "C0002871#ent", "<e2>", "from", "protein", "energy", "malnutrition", "myelodysplasia", "and", "iron", "deficiency"], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [20, 21]}}
{"token": ["Pharmacokinetic", "profiles", "omeprazole", "and", "C0050940#ent", "<e1>", "were", "well", "correlated", "with", "the", "C0960580#ent", "<e2>", "genotype", "."], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [11, 12]}}
{"token": ["C0050940#ent", "<e1>", "is", "affected", "by", "polymorphism", "of", "C0960580#ent", "<e2>", "."], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [7, 8]}}
{"token": ["After", "5", "days", "dopamine", ",", "C0041260#ent", "<e1>", "and", "L-DOPA", "passively", "C0031165#ent", "<e2>", "through", "the", "membrane", "as", "indicated", "by", "fittings", "with", "a", "first-order", "kinetic", "process", "equation", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031165", "name": "C0031165#ent", "pos": [10, 11]}}
{"token": ["This", "study", "showed", "that", "C0296800#ent", "<e1>", "had", "a", "beneficial", "effect", "on", "C0042109#ent", "<e2>", ",", "particularly", "pruritus", ",", "and", "the", "patient-reported", "symptoms", "."], "h": {"id": "C0296800", "name": "C0296800#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [11, 12]}}
{"token": ["Human", "blood", "platelets", "high", "levels", "of", "C0387990#ent", "<e1>", "the", "Src", "family", "particularly", "C3853644#ent", "<e2>", ",", "suggesting", "an", "important", "role", "for", "these", "enzymes", "in", "platelet", "physiology"], "h": {"id": "C0387990", "name": "C0387990#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [12, 13]}}
{"token": ["We", "evaluated", "the", "effect", "of", "HP", "infection", "healing", "and", "symptom", "relief", "in", "C0017168#ent", "<e1>", "patients", "with", "erosive", "esophagitis", "treated", "with", "C0081876#ent", "<e2>", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0081876", "name": "C0081876#ent", "pos": [20, 21]}}
{"token": ["With", "C0017168#ent", "<e1>", "the", "pooled", "results", "from", "two", "comparative", "studies", "that", "C0081876#ent", "<e2>", "(", "40", "mg/day", "and", "80", "mg/day", ")", "was", "superior", "to", "ranitidine", "(", "150", "mg", "twice", "daily", ")", "in", "healing", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0081876", "name": "C0081876#ent", "pos": [11, 12]}}
{"token": ["Luminal", "secretory", "cells", "p63", ",", "K5", ",", "and", "C1416717#ent", "<e1>", "but", "express", "high", "levels", "of", "C4284124#ent", "<e2>", ",", "K18", ",", "androgen", "receptor", "and", "PSA", "."], "h": {"id": "C1416717", "name": "C1416717#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [15, 16]}}
{"token": ["Although", "TRPC5", "was", "stimulated", "by", "agonists", "at", "G-protein-coupled", "receptors", "TRPC5", "activation", "by", "C1418392#ent", "<e1>", "occurred", "downstream", "and", "independently", "of", "C1366525#ent", "<e2>"], "h": {"id": "C1418392", "name": "C1418392#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366525", "name": "C1366525#ent", "pos": [19, 20]}}
{"token": ["Likewise", ",", "C0917798#ent", "<e1>", "more", "likely", "secondary", "to", "hypoxic", ",", "ischemic", "events", "to", "thromboembolic", "or", "C0596298#ent", "<e2>"], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0596298", "name": "C0596298#ent", "pos": [15, 16]}}
{"token": ["Stepwise", "logistic", "regression", "analysis", "revealed", "an", "inverse", "relation", "between", "C0917798#ent", "<e1>", "the", "presence", "of", "mitral", "valve", "prolapse", "hypertension", ",", "diabetes", "mellitus", "C0596298#ent", "<e2>", "and", "completed", "stroke", "at", "p", "less", "than", "0.01", "."], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0596298", "name": "C0596298#ent", "pos": [21, 22]}}
{"token": ["The", "cortex", "peptidoglycan", "C1845292#ent", "<e1>", "mutant", "spores", "had", "more", "C0030956#ent", "<e2>", "a", "higher", "degree", "of", "peptide", "cross-linking", ",", "and", "possibly", "less", "muramic", "acid", "lactam", "than", "that", "of", "wild-type", "spores", "."], "h": {"id": "C1845292", "name": "C1845292#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}}
{"token": ["Interference", "with", "the", "expression", "or", "the", "activity", "of", "PP5", "leads", "to", "impairment", "of", "the", "ATR-mediated", "phosphorylation", "of", "C2984188#ent", "<e1>", "and", "Chk1", "after", "UV", "or", "C0020402#ent", "<e2>", "treatment", "."], "h": {"id": "C2984188", "name": "C2984188#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [24, 25]}}
{"token": ["When", "introduced", "into", "the", "S.", "Pombe", "rad17", "mutant", ",", "C2984188#ent", "<e1>", "was", "able", "to", "partially", "revert", "its", "C0020402#ent", "<e2>", "and", "ionizing", "radiation", "hypersensitivity", "but", "not", "its", "UV", "hypersensitivity"], "h": {"id": "C2984188", "name": "C2984188#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [17, 18]}}
{"token": ["High", "levels", "norepinephrine", "in", "the", "heart", "are", "cardiotoxic", "resulting", "in", "C0242350#ent", "<e1>", "arrhythmic", "activity", "via", "C0001644#ent", "<e2>", "mediated", "mechanisms", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [15, 16]}}
{"token": ["The", "polyamine", "biosynthesis", "inhibitor", "D", "C0002260#ent", "<e1>", "DFMO", ")", "has", "C0072454#ent", "<e2>", "and", "cytotoxic", "effects", "various", "human", "tumor", "cell", "lines", "in", "vitro"], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0072454", "name": "C0072454#ent", "pos": [10, 11]}}
{"token": ["The", "C3853646#ent", "<e1>", "oncogene", "present", "in", "Moloney", "murine", "sarcoma", "virus", "one", "of", "the", "oldest", "known", "C0037207#ent", "<e2>", ",", "yet", "the", "identification", "of", "its", "biochemical", "function", "in", "transformation", "and", "as", "a", "cellular", "proto-oncogene", "been", "elusive", "."], "h": {"id": "C3853646", "name": "C3853646#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037207", "name": "C0037207#ent", "pos": [15, 16]}}
{"token": ["The", "C0225326#ent", "<e1>", "shortening", "velocity", "increased", "during", "C0000975#ent", "<e2>", "and", "bicarbonate", "dialysis", "patients", "with", "a", "normal", "left", "ventricular", "function", "whereas", "in", "patients", "with", "impaired", "left", "ventricular", "function", "fibre", "velocity", "increased", "only", "during", "bicarbonate", "dialysis"], "h": {"id": "C0225326", "name": "C0225326#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [7, 8]}}
{"token": ["PRA1", "domain", "family", "member", "2", "C1366777#ent", "<e1>", ")", "is", "a", "novel", "19-kDa", "protein", "with", "a", "C1419221#ent", "<e2>", "PRA1", ")", "motif", "and", "four", "transmembrane", "domains"], "h": {"id": "C1366777", "name": "C1366777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419221", "name": "C1419221#ent", "pos": [15, 16]}}
{"token": ["Patients", "with", "C1705280#ent", "<e1>", "were", "more", "severely", "C0231218#ent", "<e2>", "and", "had", "a", "higher", "mortality", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [7, 8]}}
{"token": ["Although", "cholesterol", "is", "a", "dominant", "membrane", "lipid", "interdigitates", "with", ",", "and", "impacts", ",", "phospholipid", "homeostasis", "its", "fate", "during", "the", "induction", "and", "recovery", "phases", "acute", "renal", "failure", "C1705280#ent", "<e1>", ")", "has", "remained", "C0231218#ent", "<e2>", "defined", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [31, 32]}}
{"token": ["C0006272#ent", "<e1>", "a", "severe", ",", "often", "progressive", ",", "lung", "disease", "by", "C3815497#ent", "<e2>", ",", "exertional", "dyspnea", "and", "airflow", "obstruction", "."], "h": {"id": "C0006272", "name": "C0006272#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3815497", "name": "C3815497#ent", "pos": [11, 12]}}
{"token": ["In", "a", "splenectomized", "patient", "with", "metastatic", "carcinoma", "the", "colon", ",", "P", "malariae", "infection", "was", "associated", "with", "C0302809#ent", "<e1>", "course", "simulating", "C0024534#ent", "<e2>"], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0024534", "name": "C0024534#ent", "pos": [20, 21]}}
{"token": ["In", "secreted", "C1706005#ent", "<e1>", "polymers", ",", "Asn563", "bears", "high-mannose", "oligosaccharides", "typical", "of", "C0251914#ent", "<e2>", "while", "complex", "sugars", "are", "found", "at", "the", "other", "four", "sites", "(", "Brenckle", "and", "Kornfeld", ",", "1980", "Arch", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0251914", "name": "C0251914#ent", "pos": [12, 13]}}
{"token": ["To", "validate", "this", "cation-pi", "interaction", ",", "natural", "and", "C0301713#ent", "<e1>", "site-specifically", "incorporated", "into", "squalene-hopene", "cyclase", "C1705297#ent", "<e2>", ")", "from", "Alicyclobacillus", "acidocaldarius", "the", "kinetic", "data", "the", "mutants", "were", "compared", "with", "that", "of", "the", "wild-type", "C1705297#ent", "<e2>", "."], "h": {"id": "C0301713", "name": "C0301713#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [15, 16]}}
{"token": ["2,6-Dichlorophenyl", "C0012403#ent", "<e1>", "(", "2,6-diClPh-MeSO2", ")", "induces", "persistent", "olfactory", "mucosal", "metaplasia", "a", "strong", "C1415042#ent", "<e2>", "increase", "in", "the", "olfactory", "bulb", "mice", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415042", "name": "C1415042#ent", "pos": [13, 14]}}
{"token": ["Methylprednisolone", "succinate", "C0023786#ent", "<e1>", ")", "was", "attached", "to", "C0086140#ent", "<e2>", "25", "kDa", "using", "linkers", "with", "1", "-", "5", "Gly", "residues", "."], "h": {"id": "C0023786", "name": "C0023786#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [8, 9]}}
{"token": ["The", "sequences", "also", "indicated", "that", "while", "the", "amplification", "products", "the", "Zhejiang", "and", "Philippine", "isolates", "contained", "a", "recognition", "site", "the", "C0059212#ent", "<e1>", "there", "was", "no", "such", "site", "in", "the", "Anhui", "C1875400#ent", "<e2>", "."], "h": {"id": "C0059212", "name": "C0059212#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [29, 30]}}
{"token": ["Topical", "application", "C0360097#ent", "<e1>", "reportedly", "blunts", "cholecystokinin", "release", "from", "intestinal", "mucosa", "reduces", "sphincter", "of", "C0546878#ent", "<e2>"], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0546878", "name": "C0546878#ent", "pos": [14, 15]}}
{"token": ["Two", "techniques", "were", "used", "to", "search", "for", "the", "C1305923#ent", "<e1>", "encoded", "by", "the", "avian", "sarcoma", "virus", "C3491974#ent", "<e2>", ")", "src", "gene"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3491974", "name": "C3491974#ent", "pos": [16, 17]}}
{"token": ["This", "tropinin-like", "complex", ",", "with", "C1420872#ent", "<e1>", "confers", "Ca2", "+", "sensitivity", "to", "the", "actin-activated", "myosin", "adenosinetriphosphatase", "C0003652#ent", "<e2>", "EC", "3.6.1.3", "."], "h": {"id": "C1420872", "name": "C1420872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003652", "name": "C0003652#ent", "pos": [16, 17]}}
{"token": ["To", "investigate", "diastolic", "dynamics", "of", "the", "left", "ventricle", "postextrasystolic", "(", "PES", ")", "beats", "during", "C0151744#ent", "<e1>", "induced", "by", "rapid", "atrial", "pacing", "C1416920#ent", "<e2>", ")", ",", "transmitral", "blood", "flow", "velocity", "evaluated", "using", "pulsed", "Doppler", "echocardiography", "13", "subjects", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1416920", "name": "C1416920#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "immunostaining", "for", "C1429056#ent", "<e1>", "surface", "chemistry-dependent", "differences", "in", "C2986638#ent", "<e2>", "differentiation", "following", "the", "pattern", "OH", ">", "CH(3", ")", ">"], "h": {"id": "C1429056", "name": "C1429056#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986638", "name": "C2986638#ent", "pos": [10, 11]}}
{"token": ["Anti-human", "immunodeficiency", "virus-1", "HIV-1", ")", "polyamide", "(", "peptide", ")", "nucleic", "acids", "PNAs", ")", "conjugated", "with", "cell-penetrating", "peptides", "C1840061#ent", "<e1>", ")", "targeted", "to", "the", "viral", "genome", "potent", "virucidal", "and", "C0003451#ent", "<e2>"], "h": {"id": "C1840061", "name": "C1840061#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [28, 29]}}
{"token": ["Carbacyclin", "and", "6", "C0283543#ent", "<e1>", "also", "lowered", "by", "1.5", "-", "2-fold", "the", "triglyceride", "and", "C0008385#ent", "<e2>", "in", "cells", "cultured", "from", "atherosclerotic", "lesions"], "h": {"id": "C0283543", "name": "C0283543#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [14, 15]}}
{"token": ["One-hour", "pretreatment", "with", "dimethyl", "sulfoxide", "a", "scavenger", "of", "hydroxyl", "radicals", ",", "deferoxamine", "(", "an", "iron", "chelator", "or", "C0016755#ent", "<e1>", "also", "blocked", "inactivation", "of", "C1412127#ent", "<e2>", "ATP", "depletion", "and", "the", "neuronal", "damage", "induced", "by", "FC", "and", "spreading", "depression"], "h": {"id": "C0016755", "name": "C0016755#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1412127", "name": "C1412127#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "C1442758#ent", "<e1>", "and", "sphingosine", "join", "C1424276#ent", "<e2>", "among", "the", "biologically", "active", "lipids", "with", "angiogenic", "potential", "."], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424276", "name": "C1424276#ent", "pos": [7, 8]}}
{"token": ["Glucose", "intolerance", "altered", "insulin", "secretion", "QTLSCS", "rats", "when", "compared", "with", "BN", "controls", "were", "consistent", "with", "C0597336#ent", "<e1>", "features", "in", "a", "C1415014#ent", "<e2>", "x", "BN", "F(2", ")", "cross", "."], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415014", "name": "C1415014#ent", "pos": [20, 21]}}
{"token": ["Radiation", "hybrid", "analysis", "localized", "the", "seipin", "gene", "(", "Bscl2", ")", "in", "rat", "to", "a", "major", "C0597336#ent", "<e1>", "rat", "chromosome", "1", "to", "glucose", "intolerance", "the", "Goto-Kakizaki", "(", "C1415014#ent", "<e2>", ")", "rat", "model", "of", "Type", "2", "diabetes"], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415014", "name": "C1415014#ent", "pos": [26, 27]}}
{"token": ["Here", "we", "show", "that", "C1425013#ent", "<e1>", "and", "a", "deletion", "mutant", "of", "C1425013#ent", "<e1>", "lacking", "the", "extracellular", "domain", "SefIC", ")", "physically", "interact", "with", "C3812805#ent", "<e1>", "(", "transforming", "growth", "factor-beta-associated", "kinase", "and", "activate", "JNK", "through", "a", "TAK1-MKK4-JNK", "pathway", "."], "h": {"id": "C1425013", "name": "C1425013#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3812805", "name": "C3812805#ent", "pos": [22, 23]}}
{"token": ["Tel2", "bound", "to", "C3146829#ent", "<e1>", "interacts", "with", "various", "phosphatidyl", "inositol", "kinase", "C0010536#ent", "<e2>", "including", "Tra1", ",", "Tra2", "and", "Rad3", ",", "as", "well", "as", "Tor1", "and", "Tor2", "."], "h": {"id": "C3146829", "name": "C3146829#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [11, 12]}}
{"token": ["The", "C0162572#ent", "<e1>", "parasite", "Cryptosporidium", "parvum", "persistent", "diarrhea", "and", "C0022806#ent", "<e2>", "in", "children", "and", "the", "diarrhea-wasting", "syndrome", "in", "AIDS", "."], "h": {"id": "C0162572", "name": "C0162572#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022806", "name": "C0022806#ent", "pos": [9, 10]}}
{"token": ["This", "study", "retrospectively", "analyzed", "patients", "with", "severe", "functional", "C1705312#ent", "<e1>", "presenting", "with", "common", "clinical", "features", "suggesting", "a", "distinct", "C0039082#ent", "<e2>", "."], "h": {"id": "C1705312", "name": "C1705312#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}}
{"token": ["The", "HIV-1", "C3273837#ent", "<e1>", "downregulates", "the", "cell-surface", "expression", "of", "C0017355#ent", "<e2>", "and", "probably", "thereby", "promotes", "immune", "evasion", "HIV-1", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [9, 10]}}
{"token": ["The", "protein", "expressions", "HER-2", ",", "NF-KB", ",", "and", "the", "protein", "phosphorylation", "HER-2", "were", "downregulated", ",", "however", "the", "protein", "expression", "p53", "and", "C1420626#ent", "<e1>", "was", "upregulated", "after", "C0073177#ent", "<e2>", "lysinate", "treatment", "."], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0073177", "name": "C0073177#ent", "pos": [26, 27]}}
{"token": ["Twenty", "five", "C0030612#ent", "<e1>", "were", "anaesthetized", "by", "administration", "of", "0.3", "mg", "C0700541#ent", "<e2>", "per", "kg", "body", "weight", "intravenously", "before", "emergence", "of", "the", "head", "of", "the", "newborn", "infant", "."], "h": {"id": "C0030612", "name": "C0030612#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700541", "name": "C0700541#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "C3539611#ent", "<e1>", "binds", "to", "Rac", "and", "C1419385#ent", "<e2>", "both", "the", "GDP-", "and", "guanosine", "5'-3-O-(thio)triphosphate-bound", "states", "without", "detectable", "affinity", "for", "Cdc42", "or", "Ras", "."], "h": {"id": "C3539611", "name": "C3539611#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [8, 9]}}
{"token": ["The", "enzyme", "responsible", "was", "cloned", "from", "a", "T.", "brucei", "brucei", "genomic", "DNA", "library", "identified", "as", "type", "I", "PGP", "(", "C1422070#ent", "<e1>", ",", "belonging", "to", "the", "C1426119#ent", "<e2>", "cysteine", "peptidases"], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1426119", "name": "C1426119#ent", "pos": [25, 26]}}
{"token": ["Most", "C0029928#ent", "<e1>", "benign", ",", "with", "the", "majority", "being", "functional", "C0029927#ent", "<e2>", "benign", "neoplasms"], "h": {"id": "C0029928", "name": "C0029928#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0029927", "name": "C0029927#ent", "pos": [10, 11]}}
{"token": ["The", "messenger", "RNA", "C1413036#ent", "<e1>", "had", "a", "span", "of", "4.6", "kb", ",", "and", "its", "C0014442#ent", "<e2>", "was", "designated", "ADAMTS", "13"], "h": {"id": "C1413036", "name": "C1413036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["These", "results", "indicate", "that", "the", "high", "[TTP]/[TDP", "]", "molar", "ratio", "in", "chicken", "white", "muscle", "was", "demonstrated", "in", "vitro", "the", "purified", "chicken", "cytosolic", "adenylate", "kinase", "support", "in", "vivo", "C1413036#ent", "<e1>", "synthesis", "by", "this", "C0014442#ent", "<e2>", "."], "h": {"id": "C1413036", "name": "C1413036#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [32, 33]}}
{"token": ["We", "report", "that", "the", "PP2A", "regulatory", "subunit", "B56alpha", "an", "in", "vivo", "binding", "partner", "for", "ankyrin-B", ",", "an", "C1332163#ent", "<e1>", "for", "normal", "subcellular", "localization", "the", "Na/Ca", "exchanger", ",", "Na/K", "C1706373#ent", "<e2>", ",", "and", "inositol", "1,4,5-trisphosphate", "receptor"], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [28, 29]}}
{"token": ["The", "selective", "C0257535#ent", "<e1>", "SB", "203580", ",", "increased", "constitutive", "C0014457#ent", "<e2>", "apoptosis", "in", "both", "populations", "(", "EC(50", ")", "approximately", "2", "microM", ")", "as", "evinced", "from", "morphological", "analysis", "flow", "cytometry", "and", "DNA", "laddering", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [9, 10]}}
{"token": ["Abca1", ",", "C1422255#ent", "<e1>", ",", "and", "Abcg8", "are", "well-established", "liver", "X", "receptor", "LXR", ")", "target", "C1417679#ent", "<e2>", "."], "h": {"id": "C1422255", "name": "C1422255#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["Sitosterolemia", "is", "caused", "by", "mutations", "in", "either", "C1422255#ent", "<e1>", "or", "ABCG8", ",", "but", "simultaneous", "mutations", "of", "these", "C1417679#ent", "<e2>", "have", "never", "been", "observed", "."], "h": {"id": "C1422255", "name": "C1422255#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["Wiskott-Aldrich", "syndrome", "C0043194#ent", "<e1>", ")", "is", "caused", "by", "mutations", "in", "the", "gene", "encoding", "C1421478#ent", "<e2>", "WASP", ")", "."], "h": {"id": "C0043194", "name": "C0043194#ent", "pos": [2, 3]}, "relation": "disease_has_associated_gene", "t": {"id": "C1421478", "name": "C1421478#ent", "pos": [13, 14]}}
{"token": ["The", "presence", "of", "a", "GPI", "anchor", "confirmed", "by", "a", "lower", "expression", "of", "membrane", "C1419408#ent", "<e1>", "on", "granulocytes", "from", "patients", "with", "C1418558#ent", "<e2>", "present", "cells", "lacking", "GPI", "anchor", "proteins"], "h": {"id": "C1419408", "name": "C1419408#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418558", "name": "C1418558#ent", "pos": [20, 21]}}
{"token": ["Various", "stimuli", "have", "been", "used", "in", "clinical", "practice", "test", "islet", "function", "including", "intravenous", "glucose", "arginine", "--", "both", "at", "basal", "glucose", "levels", "with", "the", "hyperglycaemic", "clamp", "C0724709#ent", "<e1>", ",", "glucagon", "and", "C0061355#ent", "<e2>"], "h": {"id": "C0724709", "name": "C0724709#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0061355", "name": "C0061355#ent", "pos": [30, 31]}}
{"token": ["Restriction", "enzyme", "digests", "the", "C1257113#ent", "<e1>", "MspI", "and", "C0059181#ent", "<e2>", "indicated", "the", "lack", "of", "methylation", "of", "viral", "DNA"], "h": {"id": "C1257113", "name": "C1257113#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059181", "name": "C0059181#ent", "pos": [8, 9]}}
{"token": ["The", "activity", "of", "C0041252#ent", "<e1>", "selectively", "enhanced", "4.5-fold", "by", "the", "combination", "of", "IL-3", "with", "C1416656#ent", "<e2>", "."], "h": {"id": "C0041252", "name": "C0041252#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416656", "name": "C1416656#ent", "pos": [14, 15]}}
{"token": ["Epithelial", "damage", "the", "C0719022#ent", "<e1>", "generations", "as", "a", "result", "of", "the", "C0035690#ent", "<e2>", "demonstrated", "by", "immunocytochemistry", "and", "electron", "microscopy"], "h": {"id": "C0719022", "name": "C0719022#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035690", "name": "C0035690#ent", "pos": [11, 12]}}
{"token": ["Resistance", "was", "developed", "to", "C0011122#ent", "<e1>", ",", "clopidol", "and", "C0035780#ent", "<e2>", "by", "serially", "passaging", "this", "strain", ",", "but", "evidence", "for", "the", "development", "of", "resistance", "to", "amprolium", "was", "inconclusive", "."], "h": {"id": "C0011122", "name": "C0011122#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035780", "name": "C0035780#ent", "pos": [9, 10]}}
{"token": ["Screens", "revealed", "an", "interaction", "between", "C1705304#ent", "<e1>", "and", "a", "single", "member", "of", "the", "zinc", "finger", "family", "transcription", "factors", "C1421833#ent", "<e2>", "."], "h": {"id": "C1705304", "name": "C1705304#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421833", "name": "C1421833#ent", "pos": [18, 19]}}
{"token": ["C0015302#ent", "<e1>", "can", "narrow", "the", "spinal", "canal", "induce", "back", "and", "C0023222#ent", "<e2>"], "h": {"id": "C0015302", "name": "C0015302#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023222", "name": "C0023222#ent", "pos": [10, 11]}}
{"token": ["The", "genetic", "polymorphism", "haptoglobin", "(", "C1705568#ent", "<e1>", ")", "has", "been", "associated", "with", "C0007222#ent", "<e2>", "type", "2", "diabetes"], "h": {"id": "C1705568", "name": "C1705568#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [12, 13]}}
{"token": ["For", "two", "C1875400#ent", "<e1>", ",", "the", "primary", "wing", "web", "lesion", "took", "even", "longer", "to", "develop", "and", "resolve", "although", "these", "C1875400#ent", "<e1>", "did", "not", "cause", "C0032870#ent", "<e1>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032870", "name": "C0032870#ent", "pos": [24, 25]}}
{"token": ["Prior", "to", "C4049859#ent", "<e1>", "2", "had", "hemiplegia", ",", "4", "C1537624#ent", "<e2>", ",", "one", "optic", "atrophy", "suspicion", "in", "3", "."], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1537624", "name": "C1537624#ent", "pos": [9, 10]}}
{"token": ["Erbium--169", "was", "compared", "with", "C0077004#ent", "<e1>", "the", "topical", "treatment", "32", "patients", "suffering", "from", "C0038013#ent", "<e2>"], "h": {"id": "C0077004", "name": "C0077004#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [13, 14]}}
{"token": ["Pregnancy", "complications", "have", "been", "analyzed", "in", "124", "females", "suffering", "from", "C0155583#ent", "<e1>", "EH", ")", "and", "C0152451#ent", "<e2>", "CGN", ")", "."], "h": {"id": "C0155583", "name": "C0155583#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0152451", "name": "C0152451#ent", "pos": [15, 16]}}
{"token": ["These", "data", "provide", "direct", "evidence", "that", "C0393003#ent", "<e1>", "is", "activated", "during", "C2917660#ent", "<e2>", "starvation", "and", "is", "critical", "for", "optimal", "survival", "under", "these", "conditions", "."], "h": {"id": "C0393003", "name": "C0393003#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [11, 12]}}
{"token": ["Early", "studies", "with", "C0025598#ent", "<e1>", "demonstrated", "an", "increase", "in", "global", "fibrinolytic", "activity", "patients", "with", "coronary", "artery", "disease", "C0085096#ent", "<e2>", "diabetes", "."], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [17, 18]}}
{"token": ["This", "paper", "examines", "the", "equilibrium", "and", "stability", "properties", "of", "relatively", "simple", "mathematical", "models", "the", "transmission", "of", "C0005943#ent", "<e1>", "as", "measles", ",", "C0035920#ent", "<e2>", ",", "and", "mumps", "."], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035920", "name": "C0035920#ent", "pos": [21, 22]}}
{"token": ["S3.13", "precipitates", "a", "C0030956#ent", "<e1>", "of", "Mr", "29,000", ",", "and", "C2698598#ent", "<e2>", "precipitates", "a", "C0030956#ent", "<e1>", "of", "Mr", "20,000", "present", "on", "the", "surface", "of", "all", "the", "cell", "types", "tested", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2698598", "name": "C2698598#ent", "pos": [10, 11]}}
{"token": ["To", "compare", "the", "risk", "of", "having", "C0032460#ent", "<e1>", "PCOS", ")", "or", "C0029927#ent", "<e2>", "women", "with", "genetically", "confirmed", "familial", "partial", "lipodystrophy", "FPLD", ")", "with", "that", "in", "the", "general", "population", "healthy", "women", "."], "h": {"id": "C0032460", "name": "C0032460#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0029927", "name": "C0029927#ent", "pos": [11, 12]}}
{"token": ["This", "injection", "of", "LH", "did", "not", "influence", "the", "secretion", "of", "estrogens", "by", "normal", "ovaries", "but", "greatly", "increased", "that", "by", "C0032460#ent", "<e1>", "suggesting", "that", "there", "was", "abnormal", "steroidogenesis", "in", "C0029927#ent", "<e2>"], "h": {"id": "C0032460", "name": "C0032460#ent", "pos": [19, 20]}, "relation": "related_to", "t": {"id": "C0029927", "name": "C0029927#ent", "pos": [28, 29]}}
{"token": ["Genomic", "DNA", "C1704997#ent", "<e1>", ")", "encoding", "the", "C0003967#ent", "<e2>", "ASO", ")", "of", "cucumber", "(", "Cucumis", "sativas", "was", "cloned", "and", "sequenced", "."], "h": {"id": "C1704997", "name": "C1704997#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003967", "name": "C0003967#ent", "pos": [7, 8]}}
{"token": ["C0539636#ent", "<e1>", "Mnk1", ")", "is", "a", "C0031727#ent", "<e2>", "activated", "through", "both", "the", "stress-", "and", "cytokine-activated", "p38", "MAPK", "pathway", "and", "the", "classical", "extracellular", "signal-regulated", "kinase", "1/2", "ERK1/2", ")", "pathway", "."], "h": {"id": "C0539636", "name": "C0539636#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}}
{"token": ["MAPK", "signal-integrating", "kinase", "1", "C0539636#ent", "<e1>", ")", "is", "a", "C0031727#ent", "<e2>", "activated", "through", "both", "the", "stress-", "and", "cytokine-activated", "p38", "MAPK", "pathway", "and", "the", "classical", "extracellular", "signal-regulated", "kinase", "1/2", "ERK1/2", ")", "pathway", "."], "h": {"id": "C0539636", "name": "C0539636#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}}
{"token": ["One", "component", "of", "C1424600#ent", "<e1>", "was", "identified", "as", "the", "C1704657#ent", "<e2>", "(", "focal", "adhesion", "kinase", "Pyk2", "(", "proline-rich", "tyrosine", "kinase", "2", ",", "which", "was", "phosphorylated", "in", "a", "beta2", "integrin-", "and", "Src-family-kinase-dependent", "manner", "."], "h": {"id": "C1424600", "name": "C1424600#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704657", "name": "C1704657#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "C1412728#ent", "<e1>", "is", "a", "C0140145#ent", "<e2>", "its", "actions", "on", "other", "vasoactive", "peptides", "also", "contribute", "to", "its", "vasoactive", "effects"], "h": {"id": "C1412728", "name": "C1412728#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [7, 8]}}
{"token": ["The", "active", "ingredients", "these", "herbal", "drugs", "C0076316#ent", "<e1>", "(", "TET", ")", "and", "total", "ginseng", "saponins", "(", "C1537574#ent", "<e2>", ")", "."], "h": {"id": "C0076316", "name": "C0076316#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1537574", "name": "C1537574#ent", "pos": [16, 17]}}
{"token": ["C0152116#ent", "<e1>", "IST", ")", "is", "one", "of", "the", "most", "frequent", "C0393593#ent", "<e2>"], "h": {"id": "C0152116", "name": "C0152116#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "suggest", "that", "L-baclofen", "represents", "a", "significant", "improvement", "over", "C0004609#ent", "<e1>", "the", "treatment", "of", "C0040997#ent", "<e2>", "and", "support", "our", "laboratory", "observations", "that", "D-baclofen", "antagonizes", "the", "action", "of", "L-baclofen", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0040997", "name": "C0040997#ent", "pos": [15, 16]}}
{"token": ["Our", "results", "suggest", "that", "C0004609#ent", "<e1>", "represents", "a", "significant", "improvement", "over", "racemic", "baclofen", "the", "treatment", "of", "C0040997#ent", "<e2>", "and", "support", "our", "laboratory", "observations", "that", "D-baclofen", "antagonizes", "the", "action", "of", "C0004609#ent", "<e1>", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0040997", "name": "C0040997#ent", "pos": [16, 17]}}
{"token": ["C1333909#ent", "<e1>", "+", "inhibited", "the", "peroxidases", "from", "Golden", "delicious", "C1705568#ent", "<e2>", "and", "Red", "delicious", ",", "but", "marginal", "activation", "was", "reported", "in", "peroxidases", "from", "Golden", "delicious", "JK", "and", "Royal", "delicious", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705568", "name": "C1705568#ent", "pos": [9, 10]}}
{"token": ["This", "chemotactic", "response", "C1705592#ent", "<e1>", "was", "markedly", "reduced", "by", "pretreatment", "of", "the", "cells", "with", "either", "100", "ng/ml", "C1705592#ent", "<e1>", "(", "deactivation", ")", "or", "10(-7", ")", "M", "C1705725#ent", "<e1>", "(", "cross-deactivation", ")", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [26, 27]}}
{"token": ["A", "recently", "discovered", "family", "of", "C0030940#ent", "<e1>", "responsible", "for", "an", "autosomal-dominant", "disease", "known", "as", "C1449844#ent", "<e2>", "pseudohypoaldosteronism", "type", "II", "PHA-II", ")", "that", "features", "hyperkalemia", "and", "hyperchloremic", "metabolic", "acidosis", "accompanied", "by", "hypertension", "and", "hypercalciuria", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1449844", "name": "C1449844#ent", "pos": [14, 15]}}
{"token": ["We", "report", "the", "unusual", "occurrence", "of", "C0034063#ent", "<e1>", "unilateral", "pleurocentesis", "in", "a", "young", "male", "without", "C0018799#ent", "<e2>"], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [15, 16]}}
{"token": ["However", ",", "the", "highly", "active", "yeast", "ribosomes", "(", "up", "to", "48", "pmol", ")", "displayed", "virtually", "no", "ATPase", "(", "or", "C0018296#ent", "<e1>", ")", "activity", "in", "the", "absence", "of", "C1335604#ent", "<e2>", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1335604", "name": "C1335604#ent", "pos": [27, 28]}}
{"token": ["The", "foregoing", "results", "suggest", "that", "C0040905#ent", "<e1>", "can", "not", "induce", "C1112565#ent", "<e2>", "rats", "of", "these", "two", "strains", "."], "h": {"id": "C0040905", "name": "C0040905#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1112565", "name": "C1112565#ent", "pos": [10, 11]}}
{"token": ["Most", "treatments", "were", "prescribed", "for", "C0034155#ent", "<e1>", "TTP", ";", "42", "%", ")", ",", "recurrent", "C0017668#ent", "<e2>", "FSGS", ";", "22", "%", ")", ",", "or", "myasthenia", "gravis", "MG", ";", "13", "%", ")", "."], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [14, 15]}}
{"token": ["Although", "there", "are", "patients", "who", "may", "have", "a", "primary", "form", ",", "diagnosis", "of", "C1288283#ent", "<e1>", "should", "trigger", "a", "search", "for", "C0024141#ent", "<e2>", "and/or", "antiphospholipid", "antibodies"], "h": {"id": "C1288283", "name": "C1288283#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [20, 21]}}
{"token": ["Currently", ",", "much", "attention", "is", "centered", "on", "the", "role", "of", "IL-6", "and", "TNFalpha", "in", "developing", "the", "C0015190#ent", "<e1>", "an", "effect", "on", "the", "hypothalamus", ",", "C0032002#ent", "<e2>", ",", "and", "possibly", "5'-deiodinase", "activity"], "h": {"id": "C0015190", "name": "C0015190#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [24, 25]}}
{"token": ["C1846980#ent", "<e1>", "a", "rare", "entity", "that", "combines", "familial", "juvenile", "nephronophthisis", "C0854723#ent", "<e2>"], "h": {"id": "C1846980", "name": "C1846980#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0854723", "name": "C0854723#ent", "pos": [10, 11]}}
{"token": ["The", "non-responders", "were", "additionally", "treated", "with", "C0040613#ent", "<e1>", "aprotinin", ";", "those", "with", "von", "Willebrand", "disease", "C1710605#ent", "<e2>", ")", "received", "factor", "VIII", "concentrates", "with", "von", "Willebrand", "factor", "vWF", ")", "."], "h": {"id": "C0040613", "name": "C0040613#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1710605", "name": "C1710605#ent", "pos": [15, 16]}}
{"token": ["This", "mechanism", "differs", "from", "those", "proposed", "to", "date", "in", "that", "it", "accounts", "for", "the", "inability", "of", "the", "C0024544#ent", "<e1>", "in", "general", ",", "to", "function", "as", "C0030016#ent", "<e2>"], "h": {"id": "C0024544", "name": "C0024544#ent", "pos": [17, 18]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [25, 26]}}
{"token": ["Interestingly", ",", "several", "catalytically", "important", "residues", "in", "lactate", "and", "C0024544#ent", "<e1>", "conserved", "in", "the", "primary", "structure", "C0030016#ent", "<e2>", "matched", "positions", "with", "similar", "mutual", "distances", "."], "h": {"id": "C0024544", "name": "C0024544#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [16, 17]}}
{"token": ["No", "fluorescence", "enhancement", "was", "detected", "for", "C0024544#ent", "<e1>", "or", "other", "C0030016#ent", "<e2>", "in", "this", "assay", "system", "at", "physiological", "mole", "fractions", "of", "the", "matrix", "proteins"], "h": {"id": "C0024544", "name": "C0024544#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [10, 11]}}
{"token": ["C0002893#ent", "<e1>", "activity", "is", "positively", "modulated", "by", "C0002842#ent", "<e2>", "and", "antagonized", "by", "oestrogens", "."], "h": {"id": "C0002893", "name": "C0002893#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [7, 8]}}
{"token": ["Other", "forms", "of", "C0032285#ent", "<e1>", "such", "as", "those", "caused", "by", "Haemophilus", "pleuropneumoniae", "Salmonella", "cholerae-suis", "C0033839#ent", "<e2>", "be", "important", "on", "individual", "farms", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033839", "name": "C0033839#ent", "pos": [14, 15]}}
{"token": ["Transforming", "growth", "factor-betas", "TGF-betas", ")", "have", "been", "shown", "to", "enhance", "the", "expression", "of", "C1333497#ent", "<e1>", "including", "several", "C0009325#ent", "<e2>", "."], "h": {"id": "C1333497", "name": "C1333497#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "C1333497#ent", "<e1>", "quantitative", "real-time", "reverse-transcriptase", "polymerase", "chain", "reaction", "applied", "for", "C0009325#ent", "<e2>", "collagen", "II", "biglycan", ",", "decorin", ",", "fibromodulin", ",", "fibronectin", ",", "aggrecan", ",", "and", "osteonectin", "."], "h": {"id": "C1333497", "name": "C1333497#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [12, 13]}}
{"token": ["Four", "compounds", "are", "substrates", "for", "phenylalanyl-tRNA", "synthetase", "five", "for", "C0036843#ent", "<e1>", "one", "compound", "is", "an", "inhibitor", "for", "both", "C3541394#ent", "<e2>", ";", "their", "Km", "and", "Ki", "and", "V", "values", "have", "been", "determined", "."], "h": {"id": "C0036843", "name": "C0036843#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}}
{"token": ["C0036843#ent", "<e1>", "one", "of", "two", "C3541394#ent", "<e2>", "required", "for", "tRNA", "splicing", "in", "yeast", ",", "and", "the", "enzyme", "is", "likely", "a", "single", "polypeptide", "with", "multiple", "activities"], "h": {"id": "C0036843", "name": "C0036843#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}}
{"token": ["C0036843#ent", "<e1>", "SerRSs", ")", "fall", "into", "two", "distinct", "evolutionary", "groups", "of", "C3541394#ent", "<e2>", ",", "bacterial", "and", "methanogenic", "."], "h": {"id": "C0036843", "name": "C0036843#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["Anti-smooth-muscle", "antibodies", "noted", "in", "the", "various", "autoimmune", "liver", "disorders", "C0042721#ent", "<e1>", "infectious", "mononucleosis", "malignancy", ",", "and", "intrinsic", "C0004096#ent", "<e2>"], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "both", "P50RhoGAP", "and", "its", "C3812760#ent", "<e1>", "colocalization", "with", "C0751984#ent", "<e2>", "and", "Rab5", "."], "h": {"id": "C3812760", "name": "C3812760#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [10, 11]}}
{"token": ["Priming", "the", "DC", "lines", "with", "tumour", "necrosis", "factor-alpha", "interleukin-10", "(", "IL-10", ")", "or", "C1334119#ent", "<e1>", "did", "not", "affect", "the", "IFN-alpha/beta", "response", "induced", "by", "C0019348#ent", "<e2>", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [23, 24]}}
{"token": ["C1704793#ent", "<e1>", "did", "not", "induce", "antiviral", "activity", "mouse", "L", "human", "amnion", "(", "C1423524#ent", "<e2>", ")", "cells", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423524", "name": "C1423524#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "LptA", "on", "meningococcal", "adhesion", "independent", "of", "other", "adhesins", "such", "as", "pili", ",", "C3273483#ent", "<e1>", ",", "Opa", ",", "and", "C1366566#ent", "<e2>", "but", "was", "inhibited", "by", "the", "presence", "of", "capsule", "."], "h": {"id": "C3273483", "name": "C3273483#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1366566", "name": "C1366566#ent", "pos": [21, 22]}}
{"token": ["Surprisingly", ",", "we", "also", "find", "that", "SPD-2", "is", "required", "for", "centrosome", "duplication", "C1516876#ent", "<e1>", "interacts", "with", "ZYG-1", ",", "a", "C0031727#ent", "<e2>", "required", "for", "duplication", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}}
{"token": ["Alternatively", ",", "one", "can", "C1516876#ent", "<e1>", "inactivate", "a", "C0031727#ent", "<e2>", "and", "subsequently", "characterize", "cellular", "and", "whole", "animal", "phenotypes", "without", "the", "kinase", "'s", "activity", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}}
{"token": ["The", "ability", "of", "C1522405#ent", "<e1>", "treatment", "to", "increase", "intraocular", "levels", "C1418887#ent", "<e2>", "mRNA", "diminished", "with", "the", "progression", "of", "MAIDS", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [10, 11]}}
{"token": ["In", "the", "current", "study", ",", "we", "investigated", "whether", "the", "naive", ",", "poly", "I", "C", "or", "C1522405#ent", "<e1>", "(IL-2)-induced", "natural", "killer", "(NK)/lymphokine-activated", "killer", "LAK", ")", "cells", "use", "C1418887#ent", "<e2>", "and/or", "Fas", "ligand", "FasL", ")", "to", "mediated", "cytotoxicity", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [26, 27]}}
{"token": ["We", "determined", "that", "SMC1alpha", "and", "C1704469#ent", "<e1>", "localized", "to", "C2987364#ent", "<e2>", "mouse", "meiotic", "chromosomes", "but", "with", "distinct", "differences", "in", "their", "patterns", "."], "h": {"id": "C1704469", "name": "C1704469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}}
{"token": ["At", "a", "dose", "that", "eliminated", "the", "locomotor", "depressant", "effect", "of", "clonidine", ",", "the", "alpha", "2", "C0724441#ent", "<e1>", "did", "not", "antagonize", "the", "locomotor", "C0304402#ent", "<e2>", "effects", "of", "phenylephrine", "and", "methoxamine", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [22, 23]}}
{"token": ["The", "C0304402#ent", "<e1>", "amphetamine", "also", "reduced", "submissive", "behavior", "C0724441#ent", "<e2>", "(", "also", "a", "C0304402#ent", "<e1>", ")", ",", "and", "the", "antianxiety", "agent", "diazepam", "had", "no", "such", "effect", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [1, 2]}}
{"token": ["After", "incubation", "with", "C0085171#ent", "<e1>", "contact-inhibited", "fibroblasts", "show", "reduced", "C0388638#ent", "<e2>", "recovery", "."], "h": {"id": "C0085171", "name": "C0085171#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [9, 10]}}
{"token": ["To", "understand", "the", "phylogenetic", "context", "for", "this", "dramatic", "molecular", "evolution", "we", "obtained", "sequences", "of", "C4284184#ent", "<e1>", "mtCOI", ")", ",", "and", "genomic", "sequences", "C0004371#ent", "<e2>", ",", "18-kDa", ",", "and", "a", "G", "protein", "subunit"], "h": {"id": "C4284184", "name": "C4284184#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0004371", "name": "C0004371#ent", "pos": [22, 23]}}
{"token": ["sep1", "+", "and", "spl1", "+", "perform", "closely", "related", "functions", "as", "their", "mutant", "C0002085#ent", "<e1>", "interact", "with", "each", "other", "and", "with", "another", "septation", "mutant", "C1704938#ent", "<e2>", "-", "8", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704938", "name": "C1704938#ent", "pos": [23, 24]}}
{"token": ["The", "smaller", "polypeptide", "product", "incC", "(", "C1705070#ent", "<e1>", ")", "exhibits", "a", "strong", ",", "replicon-independent", "incompatibility", "phenotype", "with", "C2346566#ent", "<e2>", "."], "h": {"id": "C1705070", "name": "C1705070#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2346566", "name": "C2346566#ent", "pos": [17, 18]}}
{"token": ["A", "case-control", "study", "conducted", "in", "HIV-infected", "patients", "who", "developed", "C0521471#ent", "<e1>", "after", "taking", "C0132326#ent", "<e2>", "(", "case", ")", "and", "those", "who", "did", "not", "have", "C0521471#ent", "<e1>", "(", "control", ")", "."], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0521471", "name": "C0521471#ent", "pos": [9, 10]}}
{"token": ["We", "report", "a", "case", "of", "a", "young", "individual", "who", "developed", "nevirapine", "(", "C0132326#ent", "<e1>", ")", "induced", "fatal", "hepatitis", "without", "apparent", "risk", "factors", "preceding", "C0521471#ent", "<e2>", "."], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0521471", "name": "C0521471#ent", "pos": [23, 24]}}
{"token": ["We", "found", "that", "C0132326#ent", "<e1>", "can", "also", "cause", "a", "significant", "C0521471#ent", "<e2>", "in", "some", "strains", "of", "rats", "."], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0521471", "name": "C0521471#ent", "pos": [10, 11]}}
{"token": ["Echocardiographic", "studies", "nowadays", "to", "measure", "the", "aortic", "root", "diameter", "to", "appreciate", "the", "left", "ventricular", "function", "to", "reveal", "a", "C0026267#ent", "<e1>", "to", "precise", "valvular", "insufficiency", "in", "young", "patients", "with", "C0024796#ent", "<e2>", "during", "family", "investigation"], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [18, 19]}, "relation": "manifestation_of", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [28, 29]}}
{"token": ["C1866956#ent", "<e1>", "noted", "in", "20", "patients", "and", "C0003504#ent", "<e2>", "six", ",", "five", "of", "whom", "had", "aortic", "regurgitation", "murmur", "5", "of", "20", "patients", "had", "undergone", "surgery", ")", "."], "h": {"id": "C1866956", "name": "C1866956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [7, 8]}}
{"token": ["C1866956#ent", "<e1>", "in", "70", "%", "of", "patients", ";", "none", "had", "severe", "C0003504#ent", "<e2>"], "h": {"id": "C1866956", "name": "C1866956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [11, 12]}}
{"token": ["Mechanical", "valve", "conduit", "replacement", "of", "the", "aortic", "root", "a", "durable", "and", "appropriate", "procedure", "for", "C1866956#ent", "<e1>", "or", "without", "C0003504#ent", "<e2>"], "h": {"id": "C1866956", "name": "C1866956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [18, 19]}}
{"token": ["We", "discuss", "the", "roles", "of", "heterozygous", "LRRK2", "mutations", "and", "heterozygous", "C1311470#ent", "<e1>", "and", "PINK1", "mutations", "in", "the", "development", "of", "C0030567#ent", "<e2>", ",", "and", "propose", "an", "integrated", "aetiological", "model", "this", "complex", "disease"], "h": {"id": "C1311470", "name": "C1311470#ent", "pos": [10, 11]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [19, 20]}}
{"token": ["Parkin-associated", "endothelin", "receptor-like", "receptor", "Pael-R", ")", "is", "a", "substrate", "of", "the", "E3", "ubiquitin", "ligase", "C1311470#ent", "<e1>", ",", "which", "has", "been", "implicated", "in", "the", "pathogenesis", "of", "C0030567#ent", "<e2>"], "h": {"id": "C1311470", "name": "C1311470#ent", "pos": [14, 15]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "CBD", "exposure", "results", "in", "the", "induction", "of", "an", "C1412365#ent", "<e1>", "that", "is", "refractory", "to", "CBD-mediated", "inactivation", ",", "thereby", "apparently", "C2712370#ent", "<e2>", "the", "cytochrome", "P-450", "composition", "of", "mouse", "hepatic", "microsomes", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [21, 22]}}
{"token": ["AVP", "and", "PRA", "elevations", "were", "found", "to", "be", "independent", "of", "the", "underlying", "C0012634#ent", "<e1>", "(", "e.g.", "respiratory", "infections", "gastroenteritis", ",", "bacterial", "infections", "the", "C0042740#ent", "<e2>", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042740", "name": "C0042740#ent", "pos": [23, 24]}}
{"token": ["However", ",", "whereas", "F-ATPases", "can", "act", "in", "both", "proton", "pumping", "C1705556#ent", "<e1>", "formation", ",", "the", "C3811804#ent", "<e2>", "of", "eukaryotes", "function", "exclusively", "as", "ATP-dependent", "proton", "pumps"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3811804", "name": "C3811804#ent", "pos": [15, 16]}}
{"token": ["C0035793#ent", "<e1>", "present", "with", "predominantly", "C0740651#ent", "<e2>", "nausea", ",", "vomiting", ",", "diarrhea", ",", "and", "abdominal", "pain"], "h": {"id": "C0035793", "name": "C0035793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0740651", "name": "C0740651#ent", "pos": [5, 6]}}
{"token": ["C0012022#ent", "<e1>", "did", "not", "modify", "the", "competitive", "inhibition", "of", "C1704949#ent", "<e2>", "and", "kainate", "currents", "by", "6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-dione", "(", "NBQX", ")", "and", "thus", "does", "not", "compete", "for", "the", "agonist", "site", "do", "C1704949#ent", "<e2>", "and", "kainate", "."], "h": {"id": "C0012022", "name": "C0012022#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [9, 10]}}
{"token": ["Many", "compounds", "were", "found", "to", "be", "more", "potent", "than", "the", "reference", "compounds", "C0012022#ent", "<e1>", "and", "aniracetam", "as", "potentiators", "of", "the", "C1704949#ent", "<e2>", "current", "in", "rat", "cortex", "Xenopus", "oocytes"], "h": {"id": "C0012022", "name": "C0012022#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [20, 21]}}
{"token": ["These", "data", "suggest", "that", "C0012022#ent", "<e1>", "acts", "at", "an", "allosteric", "site", "the", "C1704949#ent", "<e2>", "receptor/channel", "to", "potentiate", "activation", "in", "a", "manner", "dependent", "upon", "the", "properties", "of", "the", "excitatory", "agonist", "."], "h": {"id": "C0012022", "name": "C0012022#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [12, 13]}}
{"token": ["C0020197#ent", "<e1>", "digestion", "in", "the", "presence", "of", "C1449702#ent", "<e2>", "the", "results", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1449702", "name": "C1449702#ent", "pos": [7, 8]}}
{"token": ["However", ",", "site-directed", "mutations", "to", "impair", "C2744579#ent", "<e1>", "binding", "or", "hydrolysis", "did", "not", "detectably", "affect", "Arp7", "or", "C1335888#ent", "<e2>", "function", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335888", "name": "C1335888#ent", "pos": [17, 18]}}
{"token": ["Eighteen", "patients", "with", "C0020179#ent", "<e1>", "examined", "before", "and", "after", "neuroleptic", "treatment", "(", "haloperidol", ",", "C0031935#ent", "<e2>", ",", "tiapride", ")", "to", "study", "the", "effect", "of", "such", "treatment", "on", "hyperkinesia", "and", "motor", "performance"], "h": {"id": "C0020179", "name": "C0020179#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [14, 15]}}
{"token": ["The", "inability", "of", "scid", "pro-B", "cells", "progress", "to", "the", "pre-B", "and", "B", "cell", "is", "believed", "to", "be", "caused", "by", "a", "defective", "C0073020#ent", "<e1>", "fails", "to", "resolve", "chromosomal", "breaks", "from", "attempted", "C1258073#ent", "<e2>"], "h": {"id": "C0073020", "name": "C0073020#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1258073", "name": "C1258073#ent", "pos": [30, 31]}}
{"token": ["The", "closely", "linked", "recombination", "activating", "genes", ",", "rag1", "and", "rag2", ",", "encode", "components", "of", "the", "C0073020#ent", "<e1>", "involved", "in", "C1258073#ent", "<e2>", "the", "immunoglobulin", "and", "T-cell", "receptor", "genes"], "h": {"id": "C0073020", "name": "C0073020#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1258073", "name": "C1258073#ent", "pos": [19, 20]}}
{"token": ["Enterotoxic", "E.", "coli", "shigellosis", "and", "C0006818#ent", "<e1>", "are", "prevalent", "amongst", "C0004623#ent", "<e2>", "giardiasis", "is", "often", "diagnosed", "among", "protozoan", "diseases"], "h": {"id": "C0006818", "name": "C0006818#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [10, 11]}}
{"token": ["We", "have", "observed", "patients", "with", "static", "encephalopathy", "C0394007#ent", "<e1>", "of", "nearly", "equal", "severity", "with", "C0393642#ent", "<e2>", "symptomatic", "epilepsy", "and", "have", "had", "carried", "out", "comparative", "analysis", "prognosis", "among", "these", "groups", "."], "h": {"id": "C0394007", "name": "C0394007#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0393642", "name": "C0393642#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "we", "speculate", "that", "a", "relative", "deficiency", "C0042397#ent", "<e1>", "effect", "of", "C0796254#ent", "<e2>", "may", "contribute", "to", "the", "reduced", "upper", "limit", "the", "CBF", "autoregulatory", "range", "of", "the", "newborn", "."], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "that", "intraluminal", "flow", "modulates", "the", "C0042397#ent", "<e1>", "action", "of", "Ang", "II", "Af-Arts", "via", "endothelium-derived", "NO", "C0796254#ent", "<e2>", "."], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [18, 19]}}
{"token": ["C2348308#ent", "<e1>", "upregulated", "p27(Kip1)", "by", "inhibiting", "phosphorylation", "of", "mitogen-activated", "protein", "MAP", ")", "C0010536#ent", "<e2>", ",", "i.e.", ",", "ERK1/ERK2", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [12, 13]}}
{"token": ["An", "unusual", "C0683223#ent", "<e1>", "the", "Drosophila", "groucho", "gene", ",", "which", "encodes", "a", "C3541273#ent", "<e2>", "affects", "the", "fates", "of", "specific", "cells", "in", "the", "eye", "disc"], "h": {"id": "C0683223", "name": "C0683223#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541273", "name": "C3541273#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "lobeline", "on", "the", "basal", "release", "was", "[Ca(2+)]-independent", ",", "insensitive", "to", "mecamylamine", ",", "a", "C0242948#ent", "<e1>", "and", "to", "desipramine", ",", "a", "C3887648#ent", "<e2>", "uptake", "inhibitor", "."], "h": {"id": "C0242948", "name": "C0242948#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [23, 24]}}
{"token": ["We", "examined", "the", "capacity", "of", "organ", "cultured", "human", "ocular", "tissues", "produce", "and", "secrete", "C1334706#ent", "<e1>", ",", "a", "family", "of", "related", "C3540772#ent", "<e2>", "capable", "of", "digesting", "a", "variety", "of", "extracellular", "matrices"], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [20, 21]}}
{"token": ["C1145670#ent", "<e1>", "the", "inability", "to", "maintain", "adequate", "elimination", "of", "C1537986#ent", "<e2>", ",", "may", "be", "effectively", "treated", "by", "continuous", "nebulization", "of", "albuterol", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537986", "name": "C1537986#ent", "pos": [9, 10]}}
{"token": ["All", "C3831098#ent", "<e1>", "preparations", "are", "totally", "contra-indicated", "in", "C0022661#ent", "<e2>", "patients", "ingesting", "Al-containing", "compounds.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C3831098", "name": "C3831098#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [8, 9]}}
{"token": ["The", "aim", "of", "this", "case-control", "study", "to", "investigate", "the", "effects", "of", "C1418251#ent", "<e1>", "exposure", ",", "oxidative", "stress", "the", "Q192R", "polymorphism", "of", "C1418754#ent", "<e2>", "genes", ",", "and", "their", "interactions", "in", "the", "carcinogenesis", "of", "lung", "cancer"], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418754", "name": "C1418754#ent", "pos": [21, 22]}}
{"token": ["Although", "the", "acute", "neonatal", "forms", "of", "C0154246#ent", "<e1>", "almost", "always", "lethal", ",", "several", "of", "the", "subacute", "forms", "C0268542#ent", "<e2>", "favorably", "to", "early", "treatment"], "h": {"id": "C0154246", "name": "C0154246#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0268542", "name": "C0268542#ent", "pos": [17, 18]}}
{"token": ["Pitavastatin", "achieves", "its", "potent", "pharmacologic", "action", "strongly", "binding", "and", "inhibiting", "the", "active", "site", "C2975999#ent", "<e1>", "and", "has", "potent", "low-density", "lipoprotein-cholesterol-lowering", "similar", "to", "C2698196#ent", "<e2>", "and", "rosuvastatin", "."], "h": {"id": "C2975999", "name": "C2975999#ent", "pos": [13, 14]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C2698196", "name": "C2698196#ent", "pos": [22, 23]}}
{"token": ["Conversely", ",", "our", "data", "show", "that", "C1522455#ent", "<e1>", "increases", "ERK", "phosphorylation", "in", "ENU1564", "cells", ",", "increases", "C0162508#ent", "<e2>", "and", "c-fos", "mRNA", "expression", "in", "a", "time-dependent", "manner", ",", "and", "triggers", "nuclear", "translocation", "C0162508#ent", "<e2>", "."], "h": {"id": "C1522455", "name": "C1522455#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "these", "results", "suggest", "that", "maternal", "alcohol", "consumption", "increase", "the", "risk", "of", "C0038644#ent", "<e1>", "which", "has", "been", "linked", "to", "inappropriate", "C1412726#ent", "<e2>", "thermogenesis", "."], "h": {"id": "C0038644", "name": "C0038644#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [22, 23]}}
{"token": ["The", "possibility", "of", "a", "C0010823#ent", "<e1>", "be", "considered", "early", "in", "the", "evaluation", "of", "patients", "with", "C0221027#ent", "<e2>", "appropriate", "clinical", "symptoms", "present", "."], "h": {"id": "C0010823", "name": "C0010823#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221027", "name": "C0221027#ent", "pos": [15, 16]}}
{"token": ["Metformin", "and", "5-aminoimidazole-4-carboxamide-1beta-riboside", "(", "AICAR", ")", "increased", "C1418898#ent", "<e1>", "phosphorylation", ",", "inhibited", "C3273756#ent", "<e2>", "stimulation", "of", "protein", "synthesis", "and", "prevented", "high-glucose-induced", "changes", "in", "phosphorylation", "of", "4E", "binding", "protein", "1", "and", "eukaryotic", "elongation", "factor", "2"], "h": {"id": "C1418898", "name": "C1418898#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273756", "name": "C3273756#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "aging", "and", "C0011849#ent", "<e1>", "on", "the", "distribution", "of", "C1367657#ent", "<e2>", "subtypes", "in", "the", "gut", "were", "investigated", "in", "the", "BB", "rat", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [11, 12]}}
{"token": ["The", "C1527149#ent", "<e1>", "activity", "was", "independent", "of", "C4255049#ent", "<e2>", "was", "not", "inhibited", "by", "exotoxin", "A", "endosomal", "acidification"], "h": {"id": "C1527149", "name": "C1527149#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4255049", "name": "C4255049#ent", "pos": [7, 8]}}
{"token": ["Some", "of", "the", "significantly", "C3890227#ent", "<e1>", "CIS", "cells", "selected", "for", "validation", "by", "RT-PCR", "(", "IFI16", ",", "C1428097#ent", "<e2>", ",", "and", "ANXA3", ")", ",", "immunohistochemistry", "(", "HLXB9", ")", ",", "or", "in", "situ", "hybridization", "IFI16", ")", "."], "h": {"id": "C3890227", "name": "C3890227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428097", "name": "C1428097#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "the", "presence", "of", "MetS", "and", "elevated", "serum", "levels", "of", "both", "of", "these", "liver", "C3541394#ent", "<e1>", "additively", "increased", "the", "plasma", "levels", "of", "CRP", "and", "C1449789#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1449789", "name": "C1449789#ent", "pos": [26, 27]}}
{"token": ["Inhibitory", "C1415041#ent", "<e1>", "recruit", "the", "C0214604#ent", "<e2>", "block", "signals", "transduced", "by", "any", "one", "of", "a", "number", "of", "activation", "receptors"], "h": {"id": "C1415041", "name": "C1415041#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0214604", "name": "C0214604#ent", "pos": [5, 6]}}
{"token": ["The", "extensive", "labelling", "of", "PSX", "material", "for", "chondroitin", "sulfate", "an", "C0221406#ent", "<e1>", "and", "abnormal", "metabolism", "of", "C3536869#ent", "<e2>", "to", "be", "one", "of", "the", "key", "changes", "in", "this", "disorder", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536869", "name": "C3536869#ent", "pos": [16, 17]}}
{"token": ["Overexpression", "of", "either", "C0162508#ent", "<e1>", "or", "CREB-binding", "protein/p300", "partially", "relieved", "the", "suppressive", "effect", "of", "C1335238#ent", "<e2>"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [14, 15]}}
{"token": ["These", "results", "strongly", "support", "the", "clinical", "application", "this", "novel", "class", "of", "peptide/MHC", "class", "II", "constructs", "in", "patients", "with", "C0026769#ent", "<e1>", "have", "focused", "T", "cell", "responses", "to", "known", "C1417057#ent", "<e2>"], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417057", "name": "C1417057#ent", "pos": [27, 28]}}
{"token": ["Although", "no", "interaction", "between", "C0004135#ent", "<e1>", "and", "C3273507#ent", "<e2>", "was", "detected", ",", "C3273507#ent", "<e2>", "was", "found", "to", "interact", "with", "the", "MRE11/Rad50/NBS1", "(", "MRN", ")", "complex", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [7, 8]}}
{"token": ["Analysis", "of", "C0017932#ent", "<e1>", "ratio", "in", "mutant", "haploid", "cells", "that", "the", "C0027203#ent", "<e2>", "was", "less", "active", "than", "in", "wild-type", "cells", "."], "h": {"id": "C0017932", "name": "C0017932#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["Internodal", "stem", "segments", "co-cultured", "with", "Agrobacterium", "harboring", "binary", "vectors", "contained", "the", "C1417679#ent", "<e1>", "for", "the", "scorable", "marker", "\u00df-glucuronidase", "(", "C0795965#ent", "<e2>", ")", "and", "the", "selectable", "marker", "NPT-II", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0795965", "name": "C0795965#ent", "pos": [19, 20]}}
{"token": ["Competitive", "dissociation", "studies", "using", "[3H]dexamethasone", "indicate", "that", "native", "complexes", "from", "C0271801#ent", "<e1>", "rats", "show", "altered", "affinities", "for", "C2987634#ent", "<e2>", "and", "antagonist", "."], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [17, 18]}}
{"token": ["C2985250#ent", "<e1>", "also", "has", "sequence", "homology", "the", "catalytic", "domain", "C0164005#ent", "<e2>", "UCH", ")", "."], "h": {"id": "C2985250", "name": "C2985250#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0164005", "name": "C0164005#ent", "pos": [9, 10]}}
{"token": ["Blocking", "NF-kappa", "B", "I", "kappa", "B", "super-repressor", "or", "AP-1", "with", "dominant-negative", "c-Jun", "led", "to", "decreased", "basal", "C1417039#ent", "<e1>", "expression", "and", "prevented", "the", "TNF", "C0171965#ent", "<e2>", "increase", "in", "C1417039#ent", "<e1>", "expression", "."], "h": {"id": "C0171965", "name": "C0171965#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1417039", "name": "C1417039#ent", "pos": [16, 17]}}
{"token": ["The", "authors", "recommend", "that", "patients", "taking", "cholestyramine", "who", "have", "concomitant", "renal", "insufficiency", "who", "are", "volume", "depleted", "or", "who", "are", "taking", "C0037982#ent", "<e1>", "be", "monitored", "carefully", "for", "the", "emergence", "of", "a", "C0085679#ent", "<e2>", "metabolic", "acidosis"], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0085679", "name": "C0085679#ent", "pos": [30, 31]}}
{"token": ["We", "report", "the", "case", "of", "a", "57", "year-old", "man", "suffering", "from", "dyspnea", ",", "C0008031#ent", "<e1>", "arthralgia", ",", "purpura", ",", "C0036416#ent", "<e2>", "and", "tinitus", "."], "h": {"id": "C0008031", "name": "C0008031#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0036416", "name": "C0036416#ent", "pos": [19, 20]}}
{"token": ["To", "evaluate", "the", "effectiveness", "of", "GnRH", "agonist", "GnRH-a", ")", "plus", "C0076660#ent", "<e1>", "in", "the", "treatment", "of", "severe", "C0376356#ent", "<e2>", "PMS", ")", "."], "h": {"id": "C0076660", "name": "C0076660#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0376356", "name": "C0376356#ent", "pos": [17, 18]}}
{"token": ["Inhibitor", "studies", "in", "whole-embryo", "culture", "demonstrated", "a", "requirement", "for", "signalling", "via", "C0389995#ent", "<e1>", "but", "not", "C0291988#ent", "<e2>", "in", "convergent", "extension", "and", "the", "onset", "of", "neural", "tube", "closure"], "h": {"id": "C0389995", "name": "C0389995#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0291988", "name": "C0291988#ent", "pos": [15, 16]}}
{"token": ["C0070320#ent", "<e1>", "(", "4.8", "x", "10(-5", ")", "g/ml", ")", "potentiated", "C3887648#ent", "<e2>", "(", "1", "x", "10(-5", ")", "M)-induced", "phasic", "contraction", "in", "the", "epididymal", "portion", "but", "decreased", "contractions", "in", "the", "prostatic", "portion"], "h": {"id": "C0070320", "name": "C0070320#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [10, 11]}}
{"token": ["Comparative", "clinical", "studies", "that", "at", "the", "recommended", "dose", "C0287041#ent", "<e1>", ",", "the", "original", "C1254351#ent", "<e2>", "in", "this", "class", ",", "has", "a", "lower", "antihypertensive", "efficacy", "the", "newer", "agents", ",", "such", "as", "telmisartan", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}}
{"token": ["C0287041#ent", "<e1>", "is", "generally", "well", "tolerated", ";", "clinical", "trials", "shown", "the", "C1254351#ent", "<e2>", "to", "have", "a", "tolerability", "profile", "similar", "to", "that", "of", "placebo", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}}
{"token": ["Our", "data", "suggests", "that", ",", "C0287041#ent", "<e1>", "may", "be", "considered", "as", "the", "C1254351#ent", "<e2>", "of", "choice", "when", "there", "is", "a", "co-existence", "of", "diabetes", "mellitus", "hypertension", "with", "compromised", "kidney", "function"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["C0019575#ent", "<e1>", "contain", "at", "least", "as", "many", "Antennapedia-class", "and", "related", "C0017337#ent", "<e2>", "as", "insects", "do", ",", "despite", "the", "apparently", "lower", "complexity", "of", "the", "leech", "body", "plan", "."], "h": {"id": "C0019575", "name": "C0019575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["C0280858#ent", "<e1>", "and", "TMB-8", "both", "effectively", "inhibited", "epidermal", "ornithine", "decarboxylase", "C0029282#ent", "<e2>", ")", "induction", "by", "a", "single", "application", "of", "chrysarobin", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [10, 11]}}
{"token": ["Unfortunately", ",", "we", "observed", "an", "incidence", "of", "adverse", "gastrointestinal", "side", "effects", "patients", "treated", "with", "mg/day", "of", "C0031990#ent", "<e1>", "similar", "to", "that", "seen", "for", "C0003864#ent", "<e2>", "patients", "treated", "with", "mg/day", "."], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [23, 24]}}
{"token": ["The", "anion", "channel", "blocker", "4,4'-diisothiocyanatostilbene-2,2'-disulfonic", "acid", "10", "microM", ")", "was", "a", "competitive", "inhibitor", "of", "acidification", "and", "raised", "the", "Michaelis", "constant", "for", "C2744579#ent", "<e1>", "of", "the", "C1422211#ent", "<e2>", "11-fold", "in", "120", "mM", "KCl", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1422211", "name": "C1422211#ent", "pos": [25, 26]}}
{"token": ["We", "report", "two", "cases", "of", "C1416602#ent", "<e1>", "in", "the", "third", "trimester", "one", "with", "persisting", "C0013604#ent", "<e2>", "the", "other", "presenting", "with", "hydrops", "."], "h": {"id": "C1416602", "name": "C1416602#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [14, 15]}}
{"token": ["AIDS", "should", "be", "considered", "in", "the", "differential", "diagnosis", "C0221026#ent", "<e1>", "and", "it", "must", "be", "distinguished", "from", "C0242354#ent", "<e2>"], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242354", "name": "C0242354#ent", "pos": [16, 17]}}
{"token": ["The", "common", "meta", "pathway", "operons", ",", "downstream", "from", "the", "C0752501#ent", "<e1>", "to", "the", "C0079429#ent", "<e2>", "for", "catechol", "2,3-dioxygenase", "are", "highly", "homologous", "and", "clearly", "share", "a", "common", "ancestry", "."], "h": {"id": "C0752501", "name": "C0752501#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["The", "OL-2", "administered", "mice", "strongly", "expressed", "the", "interleukin", "1", "receptor", "antagonist", "C0245109#ent", "<e1>", ")", "gene", "but", "C0075018#ent", "<e2>", "administered", "mice", "did", "not", "."], "h": {"id": "C0245109", "name": "C0245109#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0075018", "name": "C0075018#ent", "pos": [16, 17]}}
{"token": ["The", "linker", "region", "by", "the", "two", "active", "sites", "human", "C1424930#ent", "<e1>", "also", "important", "for", "efficient", "packaging", "into", "HIV-1", "C0017346#ent", "<e2>", "VLP", "."], "h": {"id": "C1424930", "name": "C1424930#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [18, 19]}}
{"token": ["Like", "human", "immunodeficiency", "virus", "HIV", ")", "C0017346#ent", "<e1>", ",", "the", "MLV", "Gag", "precursor", "protein", "to", "interact", "with", "C1424930#ent", "<e2>", "indicating", "that", "C0017346#ent", "<e1>", "contains", "conserved", "structures", "are", "used", "to", "encapsidate", "C1424930#ent", "<e2>", "different", "retroviral", "particles"], "h": {"id": "C1424930", "name": "C1424930#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [6, 7]}}
{"token": ["Our", "results", "demonstrate", "that", "in", "normal", "men", "fenfluramine", "treatment", "significantly", "enhances", "plasma", "C3273356#ent", "<e1>", "levels", ",", "and", "clomiphene", "C0376259#ent", "<e2>", "treatment", "significantly", "reduces", "this", "effect", "."], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0376259", "name": "C0376259#ent", "pos": [18, 19]}}
{"token": ["Activity", "levels", "of", "C0034135#ent", "<e1>", "PNP", ")", "and", "C0001457#ent", "<e2>", "ADA", ")", "in", "PBMC", "were", "also", "measured", "."], "h": {"id": "C0034135", "name": "C0034135#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [8, 9]}}
{"token": ["Since", "then", ",", "similar", "vaccines", "have", "been", "developed", "against", "typhoid", "fever", "cholera", "and", "C0035869#ent", "<e1>", "and", "a", "nasal", "vaccine", "C0021400#ent", "<e2>", "has", "recently", "been", "registered", "in", "the", "USA", "."], "h": {"id": "C0035869", "name": "C0035869#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [19, 20]}}
{"token": ["In", "order", "to", "determine", "how", "C0078956#ent", "<e1>", "may", "reduce", "tyrosinase", "activity", "melanoma", "cells", "the", "levels", "of", "C4048300#ent", "<e2>", "mRNA", "in", "untreated", "or", "TPA-treated", "cells", "were", "determined", "by", "Northern", "blot", "analysis"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4048300", "name": "C4048300#ent", "pos": [16, 17]}}
{"token": ["To", "further", "probe", "into", "the", "role", "of", "C1539478#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0019104#ent", "<e2>", "renal", "syndrome", "HFRS", ")", "."], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [13, 14]}}
{"token": ["Further", ",", "comparing", "the", "time", "of", "C0011849#ent", "<e1>", "onset", "between", "the", "C0061323#ent", "<e2>", "and", "control", "groups", "that", "C0061323#ent", "<e2>", "delays", "C0011849#ent", "<e1>", "onset", "(", "p", "<", "0.02", ")", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0061323", "name": "C0061323#ent", "pos": [11, 12]}}
{"token": ["Semiquantitative", "Western", "blotting", "applied", "to", "measure", "C1706005#ent", "<e1>", "IgG", "titers", "against", "specific", "myelin", "proteins", "including", "C1419693#ent", "<e2>", ",", "P0", ",", "myelin", "basic", "protein", "MBP", ")", ",", "myelin-associated", "glycoprotein", "MAG", ")", "and", "PMP-22", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419693", "name": "C1419693#ent", "pos": [15, 16]}}
{"token": ["Glycation", "is", "responsible", "for", "disruption", "of", "C0815043#ent", "<e1>", "to", "the", "development", "of", "C0004153#ent", "<e2>", "in", "diabetes", "."], "h": {"id": "C0815043", "name": "C0815043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}}
{"token": ["These", "results", "indicate", "that", "C2917660#ent", "<e1>", "specifically", "decreases", "the", "level", "of", "certain", "C1334091#ent", "<e2>", "mRNA", "species", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334091", "name": "C1334091#ent", "pos": [12, 13]}}
{"token": ["The", "deduced", "kangaroo", "IGF-II", "protein", "sequence", "also", "contains", "three", "other", "C2917660#ent", "<e1>", "changes", "that", "are", "not", "observed", "in", "human", "C1334091#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334091", "name": "C1334091#ent", "pos": [19, 20]}}
{"token": ["The", "withdrawal", "symptoms", "anxiety", ",", "C0085631#ent", "<e1>", ",", "insomnia", ",", "and", "C1709099#ent", "<e2>", "most", "resistant", "to", "clonidine", "treatment", "and", "were", "reported", "by", "the", "majority", "of", "patients", "."], "h": {"id": "C0085631", "name": "C0085631#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1709099", "name": "C1709099#ent", "pos": [11, 12]}}
{"token": ["These", "three", "C0035064#ent", "<e1>", "are", "actively", "pumped", "out", "of", "cells", "by", "P-glycoprotein", "(", "C1418520#ent", "<e2>", ")", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418520", "name": "C1418520#ent", "pos": [13, 14]}}
{"token": ["C0033607#ent", "<e1>", "abolished", "the", "effect", "of", "crude", "and", "purified", "C4084825#ent", "<e2>", "on", "thyroid", "cell", "morphology", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4084825", "name": "C4084825#ent", "pos": [9, 10]}}
{"token": ["C4284736#ent", "<e1>", "induction", "by", "IL-1beta", "and/or", "TNF-alpha", "was", "mediated", "by", "C2986464#ent", "<e2>"], "h": {"id": "C4284736", "name": "C4284736#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [10, 11]}}
{"token": ["30", "children", "with", "C1539477#ent", "<e1>", "were", "examined", "for", "defects", "of", "the", "inner", "parts", "the", "C0235267#ent", "<e2>", "."], "h": {"id": "C1539477", "name": "C1539477#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [14, 15]}}
{"token": ["There", "was", "mild", "enhancement", "of", "C1539477#ent", "<e1>", "and", "FasL", "in", "the", "C0235267#ent", "<e2>", "and", "lymph", "nodes", "D609-injected", "animals", "."], "h": {"id": "C1539477", "name": "C1539477#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [11, 12]}}
{"token": ["beta-1,4-galactosyltransferase-I", "(", "C3888389#ent", "<e1>", ")", ",", "which", "is", "one", "of", "the", "best-studied", "C1333828#ent", "<e2>", ",", "plays", "a", "key", "role", "in", "the", "synthesis", "of", "type", "2", "chains", "N-glycans", "and", "the", "core", "2", "branch", "O-glycans", "."], "h": {"id": "C3888389", "name": "C3888389#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [12, 13]}}
{"token": ["The", "associated", "C0072522#ent", "<e1>", "(", "heavy", "chains)", "4F2hc", "CD98", ")", "or", "rBAT", "(", "C1414052#ent", "<e2>", ",", "NBAT", ")", "form", "the", "SLC3", "family", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [13, 14]}}
{"token": ["This", "reagent", "was", "compared", "to", "five", "previously", "characterized", "rat", "monoclonal", "antibodies", "against", "the", "C0599295#ent", "<e1>", "the", "mouse", "C1705979#ent", "<e2>", "."], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705979", "name": "C1705979#ent", "pos": [17, 18]}}
{"token": ["The", "reduction", "of", "tertiary", "phosphine", "oxides", "(", "C0021965#ent", "<e1>", ")", "and", "sulfides", "with", "C0207812#ent", "<e2>", "DIBAL-H", ")", "has", "been", "studied", "in", "detail", "."], "h": {"id": "C0021965", "name": "C0021965#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0207812", "name": "C0207812#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "hypertension", "with", "C0001645#ent", "<e1>", "three", "patients", "with", "moderately", "severe", "C0022661#ent", "<e2>", "followed", "by", "rapid", "deterioration", "of", "renal", "function"], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [11, 12]}}
{"token": ["It", "is", "also", "unknown", "whether", "additional", "treatment", "with", "C0001645#ent", "<e1>", "delay", "the", "progression", "of", "renal", "injury", "prevent", "cardiac", "injury", "C0022661#ent", "<e2>", "efficiently", "than", "conventional", "treatment", "angiotensin-converting", "enzyme", "inhibitors", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [19, 20]}}
{"token": ["The", "commonly", "used", "treatment", "with", "C0001645#ent", "<e1>", "hypertension", "in", "C0022661#ent", "<e2>", "accentuate", "certain", "of", "the", "metabolic", "responses", "uraemia", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "C0020615#ent", "<e1>", "induced", "by", "fructose", "absorption", ",", "unexplained", "C0023895#ent", "<e2>", "irritable", "bowel", "syndrome", "familial", "gout", "an", "adult", "is", "suggestive", "of", "the", "diagnosis", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [10, 11]}}
{"token": ["Hypokalemia", ",", "respiratory", "alkalosis", "C0020615#ent", "<e1>", "may", "complicate", "C0023895#ent", "<e2>"], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [8, 9]}}
{"token": ["Stimulation", "by", "ATP", "was", "inhibited", "by", "the", "P2-receptor", "antagonist", "C0038880#ent", "<e1>", ",", "and", "PMA", "stimulation", "was", "inhibited", "by", "the", "C1259877#ent", "<e2>", "PKC", ")", "inhibitor", "H-7", "."], "h": {"id": "C0038880", "name": "C0038880#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [19, 20]}}
{"token": ["Pertussis", "toxin", "C0038880#ent", "<e1>", ",", "reactive", "blue", "2", "PPADS", ",", "DPCPX", "and", "inhibitors", "of", "C1259877#ent", "<e2>", "Protein", "Kinase", "A", "PI3", "kinase", "reduced", "the", "upregulation", "of", "egr-1", "by", "exposure", "to", "extracellular", "ATP", "."], "h": {"id": "C0038880", "name": "C0038880#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [14, 15]}}
{"token": ["The", "presentation", "was", "dramatic", "with", "C0007177#ent", "<e1>", "but", "responded", "well", "to", "high", "dose", "C3536709#ent", "<e2>", "."], "h": {"id": "C0007177", "name": "C0007177#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [13, 14]}}
{"token": ["Accordingly", ",", "we", "substituted", "these", "and", "other", "divergent", "C1176140#ent", "<e1>", "SRS", "residues", "with", "the", "corresponding", "residues", "of", "C1142644#ent", "<e2>", "and/or", "CYP3A5", "."], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [17, 18]}}
{"token": ["Activation", "of", "K-Cl", "cotransport", "N-ethylmaleimide", "(", "NEM", ")", "was", "inhibited", "by", "C2744579#ent", "<e1>", "depletion", "but", "only", "partially", "inhibited", "by", "C3541971#ent", "<e2>", "and", "not", "inhibited", "by", "vanadate", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3541971", "name": "C3541971#ent", "pos": [19, 20]}}
{"token": ["Overall", ",", "C0060588#ent", "<e1>", ",", "300", "mg", ",", "was", "equivalent", "to", "C0004057#ent", "<e2>", ",", "650", "mg", "."], "h": {"id": "C0060588", "name": "C0060588#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [11, 12]}}
{"token": ["HPLC", "with", "UV", "photodiode-array", "detection", "complemented", "LC/MS", "perfectly", "by", "providing", "information", "about", "the", "C0772162#ent", "<e1>", "part", "of", "the", "C0002062#ent", "<e2>", "(", "structure", "and", "substitution", "pattern", ")", "."], "h": {"id": "C0772162", "name": "C0772162#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [18, 19]}}
{"token": ["These", "appear", "as", "well", "as", "scars", "from", "abscesses", "and", "burns", ",", "tattoos", ",", "C0011334#ent", "<e1>", "signs", "of", "C0524909#ent", "<e2>"], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "C0043167#ent", "<e1>", "inhibited", "intracellular", "calcium", "mobilization", "C1335261#ent", "<e2>", "beta(I", ")", "and", "beta(II", ")", "translocation", "from", "the", "cytosol", "to", "the", "membrane", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335261", "name": "C1335261#ent", "pos": [8, 9]}}
{"token": ["Additional", "research", "indicates", "that", "C0357126#ent", "<e1>", "be", "effective", "in", "the", "correction", "of", "other", "uncomplicated", "C0002891#ent", "<e2>", ",", "such", "as", "those", "related", "to", "antineoplastic", "therapy"], "h": {"id": "C0357126", "name": "C0357126#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002891", "name": "C0002891#ent", "pos": [14, 15]}}
{"token": ["Our", "investigation", "of", "C0219804#ent", "<e1>", "and", "binding", "of", "C1706548#ent", "<e2>", "activators", "and", "repressor", "to", "SHH", "target", "genes", "provide", "insight", "into", "the", "molecular", "mechanisms", "which", "SHH", "and", "its", "C1706548#ent", "<e2>", "family", "of", "effectors", "control", "renal", "embryogenesis"], "h": {"id": "C0219804", "name": "C0219804#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706548", "name": "C1706548#ent", "pos": [8, 9]}}
{"token": ["We", "investigated", "whether", "PB-SCs", "mobilized", "by", "treatment", "with", "C1332793#ent", "<e1>", "G-CSF", ")", "in", "normal", "rats", "can", "raise", "albumin-producing", "C0669372#ent", "<e2>", "after", "transplantation", "within", "the", "liver", "of", "analbuminemic", "rats", "."], "h": {"id": "C1332793", "name": "C1332793#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}}
{"token": ["The", "enhanced", "dsRNA-dependent", "phosphorylation", "of", "C3710914#ent", "<e1>", "was", "observed", "regardless", "of", "prior", "induction", "of", "the", "C0031727#ent", "<e2>", "with", "interferon", "."], "h": {"id": "C3710914", "name": "C3710914#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [15, 16]}}
{"token": ["2", ")", "Serum", "osteocalcin", "C3539565#ent", "<e1>", ")", "but", "not", "bone-specific", "alkaline", "phosphatase", "C1335193#ent", "<e2>", ")", "was", "lower", "by", "about", "15", "%", "in", "blacks", "than", "in", "whites", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335193", "name": "C1335193#ent", "pos": [12, 13]}}
{"token": ["Elevated", "C0017789#ent", "<e1>", "is", "implicated", "in", "the", "pathology", "of", "C1418444#ent", "<e2>", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418444", "name": "C1418444#ent", "pos": [9, 10]}}
{"token": ["C3811108#ent", "<e1>", "is", "a", "widely", "expressed", "cell", "surface", "C0752348#ent", "<e2>", "125", "kDa", "."], "h": {"id": "C3811108", "name": "C3811108#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [8, 9]}}
{"token": ["The", "two", "C0032708#ent", "<e1>", ",", "familial", "porphyria", "cutanea", "tarda", "fPCT", ")", "and", "hepatoerythropoietic", "porphyria", "C0162569#ent", "<e2>", ")", ",", "are", "associated", "with", "mutations", "in", "the", "gene", "encoding", "the", "enzyme", "uroporphyrinogen", "decarboxylase", "UROD", ")", "."], "h": {"id": "C0032708", "name": "C0032708#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162569", "name": "C0162569#ent", "pos": [14, 15]}}
{"token": ["Because", "hematopoietic", "cells", "the", "target", "for", "somatic", "gene", "therapy", "this", "C0032708#ent", "<e1>", ",", "Epstein-Barr", "virus-transformed", "B-cell", "lines", "from", "patients", "with", "C0162569#ent", "<e2>", "provide", "a", "model", "system", "the", "disease", "."], "h": {"id": "C0032708", "name": "C0032708#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162569", "name": "C0162569#ent", "pos": [20, 21]}}
{"token": ["The", "present", "study", "examines", "the", "role", "of", "brain", "networks", "C3887648#ent", "<e1>", "(", "NA", ")", "in", "the", "control", "of", "C0032002#ent", "<e2>", "beta-endorphin", "into", "systemic", "plasma"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [18, 19]}}
{"token": ["C1335274#ent", "<e1>", "(", "also", "known", "as", "C0257110#ent", "<e2>", ")", "is", "a", "non-receptor", "protein", "tyrosine", "kinase", "whose", "mRNA", "was", "expressed", "in", "the", "limited", "normal", "tissues", "as", "colon", "and", "small", "intestine", "and", "in", "breast", "carcinomas", "breast", "cancer", "cell", "lines"], "h": {"id": "C1335274", "name": "C1335274#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0257110", "name": "C0257110#ent", "pos": [6, 7]}}
{"token": ["Blockade", "of", "E-cadherin-mediated", "cell", "adhesion", "pancreatic", "islets", "the", "glucose-stimulated", "increases", "in", "intracellular", "C0001477#ent", "<e1>", "levels", "and", "insulin", "secretion", "suggesting", "that", "loss", "of", "C0694872#ent", "<e2>", "in", "beta-cells", "is", "associated", "with", "impaired", "insulin", "secretion"], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [22, 23]}}
{"token": ["In", "utero", "exposure", "of", "infant", "to", "HIV-1", ",", "regardless", "of", "C0132326#ent", "<e1>", "exposure", ",", "led", "to", "demonstrable", "increases", "in", "C1337091#ent", "<e2>", "this", "being", "most", "notable", "in", "the", "presence", "of", "preexisting", "infection", "."], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [19, 20]}}
{"token": ["Photopatch", "testing", "C0016384#ent", "<e1>", "at", "10", "and", "20", "%", "in", "C0001002#ent", "<e2>", "was", "positive", "and", "controls", "negative", "."], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [10, 11]}}
{"token": ["Various", "types", "of", "physiological", "suppressors", "deficiency", "in", "cytosolic", "superoxide", "dismutase", "isolated", ",", "whereas", "attempts", "to", "C1875400#ent", "<e1>", "suppressors", "of", "C1963826#ent", "<e2>", "a", "failure", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1963826", "name": "C1963826#ent", "pos": [19, 20]}}
{"token": ["As", "therapy", "is", "primarily", "based", "on", "NSAID", "use", ",", "in", "case", "of", "unsatifactory", "response", "in", "peripheral", "arthritis", "disease", "modyfing", "drugs", "such", "as", "C0073966#ent", "<e1>", "and", "methotexate", "(", "C1417487#ent", "<e2>", ")", "are", "used", "."], "h": {"id": "C0073966", "name": "C0073966#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [27, 28]}}
{"token": ["Together", "these", "data", "demonstrate", "a", "pivotal", "role", "for", "C1417530#ent", "<e1>", "in", "killing", "C0085423#ent", "<e2>", "modulation", "of", "NADPH", "oxidase", "in", "phagocytic", "cells"], "h": {"id": "C1417530", "name": "C1417530#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "report", "that", "C1417530#ent", "<e1>", "plays", "a", "crucial", "role", "in", "killing", "C0085423#ent", "<e2>", "primary", "macrophages", "influencing", "NADPH", "oxidase", "function"], "h": {"id": "C1417530", "name": "C1417530#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "serum", "concentrations", "of", "soluble", "C1419941#ent", "<e1>", "sPSGL-1", ")", "and", "its", "clinical", "associations", "patients", "with", "C0036421#ent", "<e2>"], "h": {"id": "C1419941", "name": "C1419941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [16, 17]}}
{"token": ["In", "C0149931#ent", "<e1>", "patients", "the", "effect", "of", "calcium", "antagonists", "flunarizine", ",", "C0042523#ent", "<e2>", "and", "nifedipine", ")", "on", "both", "venous", "and", "pupillary", "neuromuscular", "functions", "as", "well", "as", "on", "blood", "pressure", "been", "evaluated", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [11, 12]}}
{"token": ["Treatment", "for", "presumptive", "C0149931#ent", "<e1>", "with", "aura", "with", "C0042523#ent", "<e2>", "nearly", "eradicated", "symptoms", "in", "both", "patients", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [8, 9]}}
{"token": ["In", "two", "patients", "with", "the", "autosomal", "recessive", "disease", "glucose/galactose", "malabsorption", "the", "underlying", "cause", "was", "found", "to", "be", "a", "missense", "mutation", "C2699249#ent", "<e1>", ",", "and", "the", "C1421403#ent", "<e2>", "-", "->Asn", "change", "was", "demonstrated", "in", "vitro", "eliminate", "C2699249#ent", "<e1>", "transport", "activity"], "h": {"id": "C2699249", "name": "C2699249#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1421403", "name": "C1421403#ent", "pos": [25, 26]}}
{"token": ["Thus", "two", "Rab", "proteins", "two", "different", "motor", "proteins", "thereby", "controlling", "complementary", "phases", "melanosome", "biogenesis", "C1826758#ent", "<e1>", "controls", "microtubule-mediated", "transport", "early", "and", "C1624014#ent", "<e2>", "the", "subsequent", "actin-dependent", "transport", "mature", "melanosomes", "."], "h": {"id": "C1826758", "name": "C1826758#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1624014", "name": "C1624014#ent", "pos": [21, 22]}}
{"token": ["We", "show", "that", "the", "small", "GTPase", "C1826758#ent", "<e1>", "mainly", "associates", "with", "early", "and", "intermediate", "stage", "and", "C1624014#ent", "<e2>", "to", "intermediate", "and", "mature", "melanosomes", "."], "h": {"id": "C1826758", "name": "C1826758#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1624014", "name": "C1624014#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "to", "effects", "on", "c-fos", "mRNA", ",", "tamoxifen", "also", "increases", "C0567085#ent", "<e1>", "levels", "of", "c-jun", ",", "C0812313#ent", "<e2>", ",", "and", "c-myc", "mRNAs", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812313", "name": "C0812313#ent", "pos": [17, 18]}}
{"token": ["Tamoxifen", "markedly", "induced", "C0567085#ent", "<e1>", "expression", "of", "C0812313#ent", "<e2>", "mRNA", "by", "approximately", "10-fold", "over", "expression", "in", "untreated", "rats", "by", "24", "h", "after", "administration", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812313", "name": "C0812313#ent", "pos": [7, 8]}}
{"token": ["When", "expressed", "in", "C2987364#ent", "<e1>", "inhibitory", "neurons", ",", "C1832884#ent", "<e2>", "mutant", "channels", "reduced", "the", "contribution", "of", "P/Q-type", "channels", "to", "GABAergic", "synaptic", "currents", "consistent", "with", "competition", "of", "mutant", "and", "endogenous", "channels", "for", "P/Q-specific", "slots", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1832884", "name": "C1832884#ent", "pos": [8, 9]}}
{"token": ["Among", "26", "C0019069#ent", "<e1>", ",", "6", "(", "4", "haemophilia", "A", ",", "2", "C0684275#ent", "<e2>", "presented", "an", "elevation", "in", "ALT", ",", "indicating", "only", "a", "75", "%", "reduction", "of", "NANB", "viral", "contamination"], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0684275", "name": "C0684275#ent", "pos": [12, 13]}}
{"token": ["C3840167#ent", "<e1>", "coccidioidomycosis", ")", "is", "a", "C0277550#ent", "<e2>", "arid", "regions", "the", "Western", "Hemisphere", ",", "and", "is", "caused", "by", "a", "soil-dwelling", "fungus", ",", "Coccidioides", "immitis"], "h": {"id": "C3840167", "name": "C3840167#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0277550", "name": "C0277550#ent", "pos": [6, 7]}}
{"token": ["We", "suggest", "that", "C0042291#ent", "<e1>", "can", "safely", "be", "used", "with", "regard", "to", "thyroid", "and", "C0030517#ent", "<e2>", "childhood", "epilepsy"], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030517", "name": "C0030517#ent", "pos": [14, 15]}}
{"token": ["46", "patients", "suffered", "from", "familial", "hypercholesterolaemia", "another", "19", "patients", "with", "hypercholesterolaemia", "suffered", "from", "C0010054#ent", "<e1>", "21", "patients", "had", "C1704417#ent", "<e2>", "5", "patients", "had", "familial", "dysbetalipoproteinaemia"], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704417", "name": "C1704417#ent", "pos": [18, 19]}}
{"token": ["Cardiac", "transplantation", "matured", "as", "a", "therapeutic", "intervention", "allowing", "definitive", "treatment", "of", "C0010340#ent", "<e1>", "children", "and", "adults", "with", "C2316810#ent", "<e2>"], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [17, 18]}}
{"token": ["Other", "induced", "C0017337#ent", "<e1>", "include", "those", "encoding", "a", "lactate", "transporter", "C1428048#ent", "<e2>", ")", ",", "an", "extracellular", "matrix", "enzyme", ",", "MTI-MMP", "(", "membrane", "type", "1", "matrix", "metalloproteinase", "and", "an", "acute", "phase", "protein", "fibrinogen", "beta", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1428048", "name": "C1428048#ent", "pos": [10, 11]}}
{"token": ["C1447644#ent", "<e1>", "and", "RIP3", "are", "related", "C0031727#ent", "<e2>", "that", "share", "extensive", "sequence", "homology", "with", "the", "kinase", "domain", "RIP", "."], "h": {"id": "C1447644", "name": "C1447644#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}}
{"token": ["Both", "acid", "and", "C0002061#ent", "<e1>", "activities", "in", "gastrocnemius", "and", "C0023899#ent", "<e2>", "of", "prednisolone-treated", "rats", "were", "lower", "than", "levels", "in", "untreated", "rats", "."], "h": {"id": "C0002061", "name": "C0002061#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [9, 10]}}
{"token": ["However", ",", "in", "the", "presence", "of", "highly", "purified", "beta1H", "and", "C3bINA", ",", "both", "C0054398#ent", "<e1>", ",", "both", "C3b", "and", "C1412999#ent", "<e2>", "were", "cleaved", "."], "h": {"id": "C0054398", "name": "C0054398#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [19, 20]}}
{"token": ["We", "identified", "and", "studied", "a", "C0017363#ent", "<e1>", "which", "five", "members", "had", "clinical", "features", "consistent", "with", "C2931689#ent", "<e2>", "."], "h": {"id": "C0017363", "name": "C0017363#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2931689", "name": "C2931689#ent", "pos": [15, 16]}}
{"token": ["The", "ultimate", "goal", "of", "these", "investigations", "is", "to", "find", "new", "tools", "for", "prevention", "and", "treatment", "of", "these", "C0020951#ent", "<e1>", "such", "as", "C0243026#ent", "<e2>", "in", "very-low-birth-weight", "(", "VLBW", ")", "infants", "."], "h": {"id": "C0020951", "name": "C0020951#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [21, 22]}}
{"token": ["Staphylococcal", "or", "other", "bacterial", "septicemia", "in", "itself", "prove", "fatal", "and", "is", "associated", "with", "proliferative", "C0020951#ent", "<e1>", "acute", "glomerulonephritis", "which", "generally", "follows", "the", "course", "and", "prognosis", "of", "C0243026#ent", "<e2>", "."], "h": {"id": "C0020951", "name": "C0020951#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [26, 27]}}
{"token": ["The", "predicted", "secondary", "structure", "the", "proteins", "from", "hydropathy", "plots", "consistent", "with", "containing", "a", "single", "C1417327#ent", "<e1>", "at", "least", "20", "C3539946#ent", "<e2>"], "h": {"id": "C1417327", "name": "C1417327#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [19, 20]}}
{"token": ["Intermediate", "uveitis", "C0042166#ent", "<e1>", "was", "the", "single", "most", "frequently", "diagnosed", "C0042164#ent", "<e2>", "entity", "and", "accounted", "for", "92", "cases", "(", "15.4", "%", ")", "."], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [10, 11]}}
{"token": ["Differential", "diagnoses", "include", "C0042166#ent", "<e1>", "chronic", "joint", "disease", "chronic", "meningoencephalitis", "prolonged", "fever", "with", "weight", "loss", "C0042164#ent", "<e2>", "endocarditis", "with", "negative", "blood", "culture"], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [15, 16]}}
{"token": ["The", "complex", "role", "of", "C0004135#ent", "<e1>", "may", "explain", "the", "pleiotropic", "phenotype", "characteristic", "of", "C0024141#ent", "<e2>", "only", "partially", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [13, 14]}}
{"token": ["This", "increase", "in", "enzyme", "activity", "from", "an", "increase", "in", "the", "mass", "of", "C1417092#ent", "<e1>", "detected", "by", "immunotitration", "of", "enzyme", "activity", "goat", "antiserum", "against", "purified", "rat", "C4283949#ent", "<e2>"], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4283949", "name": "C4283949#ent", "pos": [25, 26]}}
{"token": ["By", "overexpression", "of", "PU.1", ",", "cell", "surface", "expression", "of", "MHC", "class", "II", "CD11b", ",", "CD11c", ",", "and", "C4284739#ent", "<e1>", "was", "induced", ",", "accompanied", "by", "reduced", "expression", "of", "C1416655#ent", "<e2>", ",", "a", "mast", "cell-specific", "marker", "."], "h": {"id": "C4284739", "name": "C4284739#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [27, 28]}}
{"token": ["Associations", "were", "analyzed", "separately", "for", "three", "clinical", "forms", "spastic", "cerebral", "palsy", "hemiplegia", ",", "diplegia", ",", "and", "C0426970#ent", "<e1>", ")", "and", "for", "C0007789#ent", "<e2>", "and", "without", "antecedent", "major", "cranial", "ultrasound", "abnormalities", "."], "h": {"id": "C0426970", "name": "C0426970#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [21, 22]}}
{"token": ["Their", "ages", "ranged", "from", "2", "to", "41", "years", "(", "mean", ":", "19.9", "years", ")", "and", "all", "of", "them", "had", "severe", "C0426970#ent", "<e1>", "due", "to", "C0007789#ent", "<e2>", "other", "conditions", "."], "h": {"id": "C0426970", "name": "C0426970#ent", "pos": [20, 21]}, "relation": "has_nichd_parent", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [24, 25]}}
{"token": ["Although", "the", "proteins", "identified", "above", "result", "from", "changes", "in", "iron", "metabolism", "i.e.", ",", "C0240066#ent", "<e1>", ",", "definitive", "evidence", "for", "C1418941#ent", "<e2>", "insufficient", "."], "h": {"id": "C0240066", "name": "C0240066#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418941", "name": "C1418941#ent", "pos": [19, 20]}}
{"token": ["In", "reproduction", ",", "participants", "were", "asked", "to", "estimate", "the", "C2926735#ent", "<e1>", "of", "a", "C1416596#ent", "<e2>", "immediately", "after", "being", "stopped", "by", "the", "experimenter", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "increased", "PTD", "treatment", "C2926735#ent", "<e1>", "led", "to", "increased", "response", "times", "on", "the", "delayed", "MTP", "C1416596#ent", "<e2>", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [16, 17]}}
{"token": ["Third", ",", "C1335236#ent", "<e1>", "and", "MAP-2b", "were", "proteolyzed", "similarly", "by", "C1413109#ent", "<e2>", ",", "although", "some", "relative", "resistance", "of", "MAP-2b", "was", "observed", "."], "h": {"id": "C1335236", "name": "C1335236#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413109", "name": "C1413109#ent", "pos": [10, 11]}}
{"token": ["These", "effects", "seem", "to", "be", "partially", "attenuated", "both", "by", "drugs", "which", "modulate", "the", "C3887648#ent", "<e1>", "well", "as", "by", "the", "serotonin", "postsynaptic", "receptor", "blocker", "C0025641#ent", "<e2>", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025641", "name": "C0025641#ent", "pos": [23, 24]}}
{"token": ["In", "addition", ",", "C4055175#ent", "<e1>", "also", "induced", "apoptosis", "in", "both", "C1704975#ent", "<e2>", "and", "MMQ", "cells", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704975", "name": "C1704975#ent", "pos": [10, 11]}}
{"token": ["Recently", "C1705783#ent", "<e1>", "was", "reported", "to", "open", "C1955862#ent", "<e2>", "arterial", "smooth", "muscle", "cells"], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1955862", "name": "C1955862#ent", "pos": [7, 8]}}
{"token": ["Endotracheal", "intubation", "intermittent", "positive", "pressure", "ventilation", "used", "to", "overcome", "the", "difficulties", "of", "oxygen", "therapy", "C0032266#ent", "<e1>", "a", "9-year-old", "child", "with", "C0013080#ent", "<e2>", "a", "congenital", "heart", "defect"], "h": {"id": "C0032266", "name": "C0032266#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013080", "name": "C0013080#ent", "pos": [20, 21]}}
{"token": ["These", "data", "suggest", "that", "C1333203#ent", "<e1>", "can", "affect", "Pax5's", "as", "an", "activator", "or", "repressor", "in", "B", "cells", "describe", "a", "role", "for", "C1333203#ent", "<e1>", "as", "a", "C1425716#ent", "<e1>"], "h": {"id": "C1333203", "name": "C1333203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425716", "name": "C1425716#ent", "pos": [25, 26]}}
{"token": ["The", "in", "vitro", "growth", "of", "the", "tumor", "in", "calf", "serum", "inhibited", "by", "C0029282#ent", "<e1>", "inhibitors", "alpha-methylornithine", "and", "C0002260#ent", "<e2>", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [12, 13]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0002260", "name": "C0002260#ent", "pos": [17, 18]}}
{"token": ["C0029282#ent", "<e1>", "activity", "decreased", "after", "etoposide", ",", "indicating", "that", "C0002260#ent", "<e2>", "exerts", "its", "effect", "by", "depleting", "cellular", "polyamines", "induction", "of", "apoptosis", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [0, 1]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0002260", "name": "C0002260#ent", "pos": [9, 10]}}
{"token": ["Twenty", "of", "the", "B.", "thuringiensis", "C1875400#ent", "<e1>", "belonged", "to", "the", "H14", "serotype", "1", "each", "to", "the", "C1415384#ent", "<e2>", "and", "H17", "serotype(s", ")", "and", "1", "to", "an", "unknown", "serotype", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415384", "name": "C1415384#ent", "pos": [16, 17]}}
{"token": ["Rheumatoid", "arthritis", "RA", ")", "is", "one", "of", "the", "most", "prevalent", "C0009782#ent", "<e1>", "can", "be", "complicated", "by", "vasculitis", "with", "C0037285#ent", "<e2>"], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [18, 19]}}
{"token": ["In", "C0009782#ent", "<e1>", "bleeding", "diasthesias", "and", "metabolic", "and", "endocrine", "disorders", "the", "C0037285#ent", "<e2>", "only", "one", "part", "of", "the", "total", "picture", "."], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [11, 12]}}
{"token": ["Marfan's", "syndrome", "a", "common", "C0009782#ent", "<e1>", "different", "musculoskeletal", ",", "ophthalmic", "and", "C0037285#ent", "<e2>"], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [11, 12]}}
{"token": ["Elimination", "of", "the", "effect", "of", "C2", "ceramide", "C0124355#ent", "<e1>", "suggests", "that", "C0037903#ent", "<e2>", "activation", "is", "mediated", "by", "a", "protein", "kinase", "important", "in", "the", "insulin-activated", "pathway"], "h": {"id": "C0124355", "name": "C0124355#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037903", "name": "C0037903#ent", "pos": [11, 12]}}
{"token": ["A", "dose", "decrease", "was", "possible", "in", "20", "%", "of", "each", "group", ",", "but", "a", "dose", "increase", "was", "necessary", "in", "39", "%", "of", "C0077857#ent", "<e1>", "and", "44", "%", "of", "C0006938#ent", "<e2>", "group", "."], "h": {"id": "C0077857", "name": "C0077857#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [28, 29]}}
{"token": ["Convulsions", "induced", "by", "the", "combination", "of", "enoxacin", ",", "a", "new", "antimicrobial", ",", "and", "nonsteroidal", "anti-inflammatory", "drugs", "C0132515#ent", "<e1>", ",", "ketoprofen", ",", "pranoprofen", "and", "C0142879#ent", "<e2>", "were", "investigated", "in", "mice", "."], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0142879", "name": "C0142879#ent", "pos": [23, 24]}}
{"token": ["These", "drugs", "included", "serotonin", "uptake", "inhibitors", "(", "imipramine", ",", "fluoxetine", ")", ",", "a", "C0019593#ent", "<e1>", "bufotenine", ")", ",", "and", "a", "neurotoxin", "(", "C0000543#ent", "<e2>", ";", "5", ",", "7-DHT", ")", "."], "h": {"id": "C0019593", "name": "C0019593#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0000543", "name": "C0000543#ent", "pos": [22, 23]}}
{"token": ["After", "several", "weeks", "of", "treatment", "with", "C0033405#ent", "<e1>", ",", "1", "day", "after", "intake", "of", "C0070122#ent", "<e2>", "he", "partially", "lost", "consciousness", "and", "developed", "extrapyramidal", "symptoms", "vegetative", "disorders"], "h": {"id": "C0033405", "name": "C0033405#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0070122", "name": "C0070122#ent", "pos": [14, 15]}}
{"token": ["The", "angiogenic", "factor", "fibroblast", "growth", "factor", "C1522505#ent", "<e1>", ")", "induces", "increased", "synthesis", "of", "both", "C0032144#ent", "<e2>", "collagenase", "in", "endothelial", "cells"], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032144", "name": "C0032144#ent", "pos": [14, 15]}}
{"token": ["Emerging", "epidemiological", "data", "that", "C0011849#ent", "<e1>", "is", "a", "potential", "predisposing", "factor", "neuropsychiatric", "deficits", "stroke", ",", "cerebrovascular", "diseases", "C0019151#ent", "<e2>", "depression", "and", "anxiety", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [17, 18]}}
{"token": ["myopia", ";", "spasm", "or", "C0030552#ent", "<e1>", "of", "accommodation", "with", "or", "without", "C0339682#ent", "<e2>", "with", "the", "rule", "\"", "and", "mild", "general", "impairments", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0339682", "name": "C0339682#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "performed", "to", "determine", "whether", "genetic", "polymorphisms", "C0596123#ent", "<e1>", "AhRR", ")", ",", "glutathione-S-transferase", "M1", "GSTM1", ")", "and", "glutathione-S-transferase", "T1", "C1333715#ent", "<e2>", ")", "are", "associated", "with", "susceptibility", "to", "advanced", "stage", "endometriosis", "in", "a", "Korean", "population"], "h": {"id": "C0596123", "name": "C0596123#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333715", "name": "C1333715#ent", "pos": [21, 22]}}
{"token": ["Of", "the", "other", "32", "patients", "with", "minor", "liver", "involvement", "four", "had", "steatosis", ",", "one", "chronic", "active", "hepatitis", "one", "C0042721#ent", "<e1>", "and", "14", "possibly", "early", "C0566602#ent", "<e2>", "unspecific", "reactive", "hepatitis"], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [24, 25]}}
{"token": ["To", "assess", "the", "influence", "of", "C0011849#ent", "<e1>", "on", "the", "development", "of", "C1835677#ent", "<e2>", "to", "show", "whether", "biomechanical", "effects", "are", "also", "reflected", "in", "epidemiology", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1835677", "name": "C1835677#ent", "pos": [11, 12]}}
{"token": ["The", "putative", "C1416427#ent", "<e1>", "IMH3", ")", "encodes", "a", "protein", "of", "521", "C3539946#ent", "<e2>", "extensive", "sequence", "similarity", "the", "IMP", "dehydrogenases", "Saccharomyces", "cerevisiae", "various", "other", "organisms", "."], "h": {"id": "C1416427", "name": "C1416427#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [11, 12]}}
{"token": ["During", "seizures", "induced", "by", "kainic", "acid", "observed", "a", "104", "%", "increase", "in", "levels", "of", "C1417815#ent", "<e1>", ",", "suggesting", "that", "C4048158#ent", "<e2>", "are", "associated", "with", "dramatically", "increased", "NPYergic", "neurotransmission", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [19, 20]}}
{"token": ["One", "of", "these", "C0086376#ent", "<e1>", "was", "characterised", ",", "by", "N-terminal", "sequencing", "as", "diazepam", "C1415855#ent", "<e2>", "gene", "maps", "6q12-q21", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415855", "name": "C1415855#ent", "pos": [13, 14]}}
{"token": ["The", "Id", "inhibitor", "of", "DNA", "binding", "C0086376#ent", "<e1>", "are", "a", "family", "of", "helix-loop-helix", "(HLH)", "proteins", "C1415855#ent", "<e2>", ",", "Id2", ",", "Id3", ",", "and", "Id4", ")", "that", "lack", "the", "basic", "domain", "necessary", "for", "DNA", "binding"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415855", "name": "C1415855#ent", "pos": [15, 16]}}
{"token": ["Double", "mutations", "C1418654#ent", "<e1>", "and", "either", "vah1", "or", "llpA", "resulted", "in", "C2987364#ent", "<e2>", "hemolytic", "activity"], "h": {"id": "C1418654", "name": "C1418654#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [11, 12]}}
{"token": ["Also", ",", "no", "size", "in", "either", "PLP", "or", "C1418654#ent", "<e1>", "mRNAs", "were", "found", "by", "S1", "nuclease", "assays", "brain", "RNA", "either", "jpmsd", "or", "C2987364#ent", "<e2>", "mice", "."], "h": {"id": "C1418654", "name": "C1418654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [22, 23]}}
{"token": ["Minocyclin", "and", "vitamin", "A", "contained", "in", "these", "substances", ",", "are", "likely", "to", "have", "induced", "the", "C0085580#ent", "<e1>", "and", "consequently", "the", "C0030353#ent", "<e2>"], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030353", "name": "C0030353#ent", "pos": [20, 21]}}
{"token": ["Consistent", "with", "hypothesis", ",", "we", "report", "that", "Cdc18", "interacts", "with", "C1418727#ent", "<e1>", "in", "association", "with", "Cdc13", "and", "C3889716#ent", "<e2>", "B-type", "cyclins", "in", "vivo"], "h": {"id": "C1418727", "name": "C1418727#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889716", "name": "C3889716#ent", "pos": [17, 18]}}
{"token": ["We", "propose", "a", "model", "for", "the", "generation", "of", "CaR-mediated", "transient", "[Ca(2+)](i", ")", "oscillations", "that", "integrates", "its", "stimulation", "by", "aromatic", "amino", "acids", "C1421168#ent", "<e1>", "regulation", "by", "C1826724#ent", "<e2>", "and", "calmodulin", "."], "h": {"id": "C1421168", "name": "C1421168#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [25, 26]}}
{"token": ["Interferon-beta", "has", "anti-viral", ",", "anti-proliferation", "and", "C1415740#ent", "<e1>", "immunomodulatory", "activities", "shows", "promising", "clinical", "effects", "treatment", "of", "C0029877#ent", "<e2>"], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [16, 17]}}
{"token": ["We", "show", "here", "that", "C3274722#ent", "<e1>", "homodimerizes", "and", "is", "capable", "of", "forming", "heterodimers", "with", "wild-type", "C0796520#ent", "<e2>", "."], "h": {"id": "C3274722", "name": "C3274722#ent", "pos": [4, 5]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0796520", "name": "C0796520#ent", "pos": [15, 16]}}
{"token": ["Based", "on", "deletion", "analysis", "the", "portion", "of", "CTR1", "that", "interacts", "with", "C1336645#ent", "<e1>", "roughly", "aligns", "with", "the", "regulatory", "region", "C1449849#ent", "<e2>"], "h": {"id": "C1336645", "name": "C1336645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1449849", "name": "C1449849#ent", "pos": [19, 20]}}
{"token": ["We", "have", "isolated", "cDNA", "clones", "for", "one", "of", "the", "C0146524#ent", "<e1>", "namely", "for", "C1420830#ent", "<e2>", ",", "of", "bull", "and", "boar", "."], "h": {"id": "C0146524", "name": "C0146524#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420830", "name": "C1420830#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "epsilon", ",", "delta", "and", "C1826724#ent", "<e1>", "isoforms", "increased", "with", "RVH", "and", "normalized", "with", "C0028066#ent", "<e2>", "treatment", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [15, 16]}}
{"token": ["Among", "mTOR", "signaling", "components", ",", "Myc", "directly", "affected", "transcription", "of", "C1860707#ent", "<e1>", "TSC2", ")", ",", "as", "shown", "by", "quantitative", "mRNA", "analysis", "by", "C1428063#ent", "<e2>", "its", "promoter", "in", "chromatin", "immunoprecipitation", "assays"], "h": {"id": "C1860707", "name": "C1860707#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1428063", "name": "C1428063#ent", "pos": [22, 23]}}
{"token": ["The", "EC50", "for", "phenylephrine", "stimulation", "of", "C0388638#ent", "<e1>", "activity", "was", "not", "altered", ",", "however", ",", "by", "C0031448#ent", "<e2>", "pretreatment", "and", "the", "associated", "up-regulation", "of", "the", "receptor", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [16, 17]}}
{"token": ["To", "report", "a", "patient", "with", "coeliac", "disease", "CD", ")", "associated", "with", "C0008312#ent", "<e1>", "PBC", ")", "who", "presented", "with", "C0026848#ent", "<e2>", "without", "classical", "symptoms", "CD", "."], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [18, 19]}}
{"token": ["We", "concluded", "that", "peripheral", "administration", "C0126174#ent", "<e1>", "as", "well", "as", "C0667944#ent", "<e2>", "can", "cause", "sufficient", "central", "effects", "prevent", "the", "sympathetic", "hyperactivity", "and", "hypertension", "induced", "by", "chronic", "peripheral", "ouabain", "and", "central", "sodium"], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0667944", "name": "C0667944#ent", "pos": [10, 11]}}
{"token": ["C1843003#ent", "<e1>", "MVP", ")", "is", "the", "most", "common", "C0018824#ent", "<e2>"], "h": {"id": "C1843003", "name": "C1843003#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [8, 9]}}
{"token": ["The", "deduced", "C2917660#ent", "<e1>", "of", "the", "putative", "EF-1", "alpha", "EF-2", "of", "C1423073#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423073", "name": "C1423073#ent", "pos": [11, 12]}}
{"token": ["Other", "C3539768#ent", "<e1>", "of", "competing", "with", "crotoxin", "for", "this", "binding", "invariably", "have", "C1421250#ent", "<e2>", "at", "this", "position", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421250", "name": "C1421250#ent", "pos": [12, 13]}}
{"token": ["The", "E1A", "gene", "adenovirus", "type", "5", "C1865868#ent", "<e1>", ")", "induces", "morphological", "transformation", "anchorage-independent", "growth", "cloned", "rat", "embryo", "fibroblast", "C1823707#ent", "<e2>", ")", "cells", "."], "h": {"id": "C1865868", "name": "C1865868#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1823707", "name": "C1823707#ent", "pos": [18, 19]}}
{"token": ["In", "C1865868#ent", "<e1>", "E1A", "and", "C1865868#ent", "<e1>", "E1A", "+", "low-level", "beta", "1", "PKC", "expressing", "C1823707#ent", "<e1>", "clones", ",", "the", "tumor", "promoting", "agent", "12", "-", "0-tetradecanoyl-phorbol-13-acetate", "(", "TPA", ")", "further", "enhances", "anchorage-independence", "."], "h": {"id": "C1865868", "name": "C1865868#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823707", "name": "C1823707#ent", "pos": [14, 15]}}
{"token": ["The", "combination", "of", "C1865868#ent", "<e1>", "E1A", "and", "low-level", "beta", "1", "PKC", "expression", "in", "the", "same", "C1823707#ent", "<e2>", "cell", "line", "in", "an", "enhanced", "ability", "to", "grow", "when", "suspended", "in", "agar", "."], "h": {"id": "C1865868", "name": "C1865868#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823707", "name": "C1823707#ent", "pos": [15, 16]}}
{"token": ["Docetaxel", "is", "a", "new", "C1519664#ent", "<e1>", "induces", "a", "predominantly", "C0151313#ent", "<e2>", "is", "mild", "in", "most", "patients", "."], "h": {"id": "C1519664", "name": "C1519664#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [9, 10]}}
{"token": ["The", "main", "components", "of", "the", "isolated", "C0003486#ent", "<e1>", "were", "the", "soluble", "p66", "and", "C1422009#ent", "<e2>"], "h": {"id": "C0003486", "name": "C0003486#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422009", "name": "C1422009#ent", "pos": [13, 14]}}
{"token": ["NF1/X", "antagonized", "the", "activity", "of", "a", "known", "C1422492#ent", "<e1>", "of", "the", "C1335200#ent", "<e2>", "Sp1", ",", "by", "inhibiting", "its", "occupancy", "of", "the", "proximal", "PDGF-A", "promoter", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335200", "name": "C1335200#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "organic", "mania", "be", "associated", "with", "drugs", "including", "L-dopa", ",", "decongestants", ",", "C0039052#ent", "<e1>", ",", "steroids", ",", "baclofen", "withdrawal", ",", "C0008783#ent", "<e2>", ",", "and", "possibly", "captopril", "."], "h": {"id": "C0039052", "name": "C0039052#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [22, 23]}}
{"token": ["The", "gastrin-releasing", "peptide", "receptor", "C2986884#ent", "<e1>", ")", "has", "emerged", "as", "a", "novel", "molecular", "target", "neurological", "and", "psychiatric", "disorders", "and", "previous", "animal", "studies", "that", "C2986884#ent", "<e1>", "antagonists", "might", "display", "cognitive-enhancing", "and", "C0040615#ent", "<e1>", "properties", "."], "h": {"id": "C2986884", "name": "C2986884#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [30, 31]}}
{"token": ["C1425141#ent", "<e1>", "up-regulates", "TCR-associated", "signaling", "events", ",", "including", "phosphorylation", "of", "C1705831#ent", "<e2>", "and", "IL-2-inducible", "T", "cell", "kinase", "."], "h": {"id": "C1425141", "name": "C1425141#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705831", "name": "C1705831#ent", "pos": [10, 11]}}
{"token": ["The", "C0079941#ent", "<e1>", "uORF", ")", "in", "the", "mRNA", "encoding", "C0036003#ent", "<e2>", "a", "cis-acting", "element", "that", "confers", "feedback", "control", "cellular", "polyamines", "translation", "of", "this", "message", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036003", "name": "C0036003#ent", "pos": [9, 10]}}
{"token": ["CRB1", "and", "CRB3", "are", "human", "C4277608#ent", "<e1>", "of", "Drosophila", "Crb", ",", "MPP1-MPP7", "are", "human", "C4277608#ent", "<e1>", "of", "Drosophila", "Sdt", ",", "INADL/PATJ", "and", "MPDZ/MUPP1", "are", "human", "C4277608#ent", "<e1>", "of", "Drosophila", "C1413248#ent", "<e1>", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413248", "name": "C1413248#ent", "pos": [29, 30]}}
{"token": ["C1567357#ent", "<e1>", "both", "ventricles", "of", "NL", "or", "C1538440#ent", "<e2>", "dogs", "increased", "with", "increasing", "Ca2", "+", "concentration", "and", "reached", "a", "plateau", "at", "3", "microM", "Ca2", "+", "."], "h": {"id": "C1567357", "name": "C1567357#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "no", "correlation", "was", "found", "between", "C0018784#ent", "<e1>", "drug", "therapy", "one", "at", "least", "of", "the", "following", "drugs", ":", "C0080151#ent", "<e2>", ",", "D-penicillamine", ",", "plaquenil", "and", "methotrexate", "."], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [20, 21]}}
{"token": ["Redox-sensing", "molecules", "such", "as", "thioredoxin", "(", "TRX", ")", "and", "glutaredoxin", "(", "C3889691#ent", "<e1>", ")", "bind", "to", "apoptosis", "C0532128#ent", "<e2>", "ASK1", ")", "and", "suppress", "its", "activation", "."], "h": {"id": "C3889691", "name": "C3889691#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0532128", "name": "C0532128#ent", "pos": [17, 18]}}
{"token": ["In", "addition", "to", "the", "cytokines", "interferon", "and", "C0879590#ent", "<e1>", "recently", "approved", "C0035064#ent", "<e2>", "include", "sorafenib", ",", "sunitinib", ",", "temsirolimus", "and", "bevacizumab", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["These", "two", "C1417589#ent", "<e1>", "thus", "appear", "to", "functionally", "mimic", "C1423680#ent", "<e2>", "."], "h": {"id": "C1417589", "name": "C1417589#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423680", "name": "C1423680#ent", "pos": [9, 10]}}
{"token": ["Despite", "the", "lack", "of", "conservation", "at", "this", "section", ",", "sites", "for", "exogenous", "cleavage", "by", "C1456349#ent", "<e1>", "a", "Leu-Ser[downward", "arrow]His", "motif", "for", "autocatalytic", "cleavage", "by", "C0007428#ent", "<e2>", "preserved", "."], "h": {"id": "C1456349", "name": "C1456349#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [24, 25]}}
{"token": ["C0162792#ent", "<e1>", "was", "observed", "on", "day", "19", "of", "C0034152#ent", "<e2>", "over", "all", "doses", "tested", "(", "0.1", "-", "1", "nmol", ")", "."], "h": {"id": "C0162792", "name": "C0162792#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [8, 9]}}
{"token": ["The", "newest", "addition", "to", "this", "group", "of", "disorders", "is", "the", "defect", "of", "C1412344#ent", "<e1>", "glycogenosis", "type", "XII", ",", "a", "block", "in", "terminal", "glycolysis", "associated", "with", "C0206157#ent", "<e2>", "and", "a", "hemolytic", "trait"], "h": {"id": "C1412344", "name": "C1412344#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0206157", "name": "C0206157#ent", "pos": [25, 26]}}
{"token": ["However", ",", "C0004623#ent", "<e1>", "important", "causes", "of", "high", "fever", "patients", "receiving", "myelosuppressive", "chemotherapy", "and", "such", "C0034362#ent", "<e2>", "persist", "despite", "the", "use", "of", "COX", "inhibitors"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0034362", "name": "C0034362#ent", "pos": [15, 16]}}
{"token": ["Each", "patient", "first", "underwent", "an", "C1822716#ent", "<e1>", "treatment", "and", "1", "week", "later", "a", "C1705998#ent", "<e2>", "treatment", "."], "h": {"id": "C1822716", "name": "C1822716#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705998", "name": "C1705998#ent", "pos": [13, 14]}}
{"token": ["When", "10", "microM", "C0029904#ent", "<e1>", ",", "a", "digitalis", "glucoside", "was", "added", "to", "C0114771#ent", "<e2>", ",", "deltaAPD", "was", "more", "pronounced", "at", "0.5", "Hz", "and", "reduced", "at", "3", "Hz", "."], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0114771", "name": "C0114771#ent", "pos": [12, 13]}}
{"token": ["Polarization", "required", "C1705590#ent", "<e1>", "the", "guanine", "nucleotide", "exchange", "factor", "Vav1", ",", "the", "C1427594#ent", "<e2>", "Cdc42", ",", "as", "well", "as", "myosin", "L", "chain", "kinase"], "h": {"id": "C1705590", "name": "C1705590#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1427594", "name": "C1427594#ent", "pos": [12, 13]}}
{"token": ["C0014130#ent", "<e1>", "as", "obesity", "and", "C0020626#ent", "<e2>", ",", "hypervitaminosis", "A", "tetracycline", "use", "and", "thyroid", "replacement", "probable", "causes", "of", "benign", "intracranial", "hypertension"], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0020626", "name": "C0020626#ent", "pos": [5, 6]}}
{"token": ["The", "inhibitory", "effects", "of", "DMPS", "and", "TPEN", "were", "associated", "with", "decreased", "binding", "of", "the", "C2826562#ent", "<e1>", "GATA-1", ",", "whereas", "no", "change", "in", "C1417708#ent", "<e2>", "observed", "."], "h": {"id": "C2826562", "name": "C2826562#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [22, 23]}}
{"token": ["A", "dose", "of", "100", "mg", "of", "C0069562#ent", "<e1>", "was", "given", "orally", "(", "tablet", ")", "to", "patients", "with", "C0085695#ent", "<e2>", "n", "=", "32", ")", "."], "h": {"id": "C0069562", "name": "C0069562#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085695", "name": "C0085695#ent", "pos": [17, 18]}}
{"token": ["The", "activated", "form", "of", "p38", "regulates", "downstream", "activation", "of", "other", "C0031727#ent", "<e1>", "notably", "MapKapK-2", "and", "C1431394#ent", "<e2>", ",", "indicating", "the", "existence", "of", "Type", "I", "signaling", "cascades", "activated", "downstream", "of", "p38", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1431394", "name": "C1431394#ent", "pos": [15, 16]}}
{"token": ["Treatment", "with", "the", "Ras", "inhibitor", "levels", "known", "to", "inhibit", "the", "H-", "and", "N-Ras", "isoforms", "had", "no", "effect", "while", "C0384074#ent", "<e1>", "levels", "known", "to", "inhibit", "C1537502#ent", "<e2>", "reduced", "only", "neurite", "length", "."], "h": {"id": "C0384074", "name": "C0384074#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [24, 25]}}
{"token": ["A", "combination", "of", "C0384074#ent", "<e1>", "and", "a", "geranylgeranyltransferase", "I", "inhibitor", "inhibited", "C1537502#ent", "<e2>", "processing", "and", "enhanced", "cell", "death", "8226", "cells", "."], "h": {"id": "C0384074", "name": "C0384074#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [11, 12]}}
{"token": ["PD98059", ",", "an", "inhibitor", "of", "the", "C1705791#ent", "<e1>", "pathway", ",", "but", "not", "KN-93", ",", "an", "inhibitor", "of", "C0006776#ent", "<e2>", "IV", ",", "also", "blocked", "HIF-1", "activation", "by", "hypoxia", "and", "by", "ionomycin", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006776", "name": "C0006776#ent", "pos": [17, 18]}}
{"token": ["Additionally", ",", "in", "several", "of", "these", "cases", ",", "the", "gene", "of", "C1420589#ent", "<e1>", "been", "localized", ",", "cloned", "and", "sequenced", ",", "exhibiting", "C0086376#ent", "<e2>", "of", "400", "to", "800", "amino", "acids", "chain", "length", "."], "h": {"id": "C1420589", "name": "C1420589#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}}
{"token": ["C0020456#ent", "<e1>", "serotonin", "concentrations", "have", "been", "reported", "in", "patients", "with", "C0034734#ent", "<e2>", "phenomenon", "and", "a", "relationship", "has", "been", "suggested", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034734", "name": "C0034734#ent", "pos": [10, 11]}}
{"token": ["Therefore", ",", "variations", "in", "the", "corresponding", "C0017337#ent", "<e1>", "might", "influence", "weight", "reduction", "C2351322#ent", "<e2>", "metabolic", "changes", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2351322", "name": "C2351322#ent", "pos": [12, 13]}}
{"token": ["Both", "5", "'", "and", "3", "'", "C0812385#ent", "<e1>", "located", "within", "Alu", "repetitive", "sequences", "which", "are", "probably", "involved", "in", "the", "C0014877#ent", "<e2>", "over", "that", "generated", "this", "rearrangement", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014877", "name": "C0014877#ent", "pos": [19, 20]}}
{"token": ["The", "results", "obtained", "in", "these", "studies", "indicate", "that", "activin", "A", "is", "a", "negative", "regulator", "of", "kidney", "development", "plays", "an", "essential", "part", "in", "C0022658#ent", "<e1>", "such", "as", "C0022660#ent", "<e2>", "renal", "fibrosis"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [22, 23]}, "relation": "nichd_parent_of", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [26, 27]}}
{"token": ["C0663241#ent", "<e1>", ":", "The", "clinical", "efficacy", "linezolid", "in", "C0004623#ent", "<e2>", "the", "skin", "and", "soft", "tissues", "comparable", "to", "that", "of", "oxacillin/dicloxacillin", "."], "h": {"id": "C0663241", "name": "C0663241#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [8, 9]}}
{"token": ["Linezolid", "is", "orally", "as", "well", "as", "intravenously", "active", "and", "orally", "administered", "C0663241#ent", "<e1>", "is", "as", "efficacious", "in", "mouse", "models", "C0004623#ent", "<e2>", "is", "subcutanously", "administered", "vancomycin", "against", "appropriate", "pathogens", "."], "h": {"id": "C0663241", "name": "C0663241#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [19, 20]}}
{"token": ["The", "FcR+", "FT", "cells", "seem", "to", "represent", "T", "lineage", "cells", "because", "a", "large", "majority", "of", "them", "express", "the", "T", "lineage", "transcription", "factors", "C1420642#ent", "<e1>", "and", "GATA-3", "as", "well", "as", "C1539080#ent", "<e2>", "the", "cytoplasm", "."], "h": {"id": "C1420642", "name": "C1420642#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1539080", "name": "C1539080#ent", "pos": [29, 30]}}
{"token": ["Genetic", "and", "biochemical", "experiments", "C1367449#ent", "<e1>", "and", "MALT1", "as", "C1136365#ent", "<e2>", "an", "oligomerization-ubiquitinylation-phosphorylation", "cascade", "that", "activates", "the", "transcription", "factor", "NF-kappaB", "response", "to", "antigen", "receptor", "ligation"], "h": {"id": "C1367449", "name": "C1367449#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [9, 10]}}
{"token": ["Expression", "of", "the", "PKCepsilon", "inhibitor", "inhibited", "PMA-induced", "C0699919#ent", "<e1>", "secretion", "and", "suppression", "of", "C1705543#ent", "<e2>", "production", "."], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [13, 14]}}
{"token": ["The", "proteases", "(", "C0699919#ent", "<e1>", ")", "which", "generate", "C1705543#ent", "<e2>", "APP", "are", "now", "being", "defined", ",", "as", "is", "the", "normal", "function", "APP", "."], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [8, 9]}}
{"token": ["Both", "C0518214#ent", "<e1>", "and", "self-rated", "health", "improved", "in", "the", "C1442521#ent", "<e2>", "patients", ",", "whereas", "no", "change", "was", "found", "in", "the", "comparison", "group", "surgery", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [9, 10]}}
{"token": ["The", "C0263859#ent", "<e1>", "a", "term", "coined", "to", "include", "a", "variety", "of", "C0009326#ent", "<e2>", "associated", "with", "skin", "conditions", "mainly", "palmoplantar", "pustulosis", "acne", "conglobata"], "h": {"id": "C0263859", "name": "C0263859#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [11, 12]}}
{"token": ["Psoriasis", "vulgaris", "C0030805#ent", "<e1>", "two", "clinically", "well-characterized", ",", "chronic", ",", "C3875321#ent", "<e2>"], "h": {"id": "C0030805", "name": "C0030805#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3875321", "name": "C3875321#ent", "pos": [10, 11]}}
{"token": ["The", "synthesis", "of", "dinucleoside", "polyphosphates", "catalyzed", "by", "C0311727#ent", "<e1>", "is", "compared", "with", "that", "catalyzed", "by", "aminoacyl-tRNA", "synthetases", "C0057682#ent", "<e2>"], "h": {"id": "C0311727", "name": "C0311727#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0057682", "name": "C0057682#ent", "pos": [17, 18]}}
{"token": ["NarA", "showed", "homology", "to", "C1422492#ent", "<e1>", ",", "a", "protein", "involved", "in", "biosynthesis", "of", "the", "C0066697#ent", "<e2>", "nitrate", "reductase", "formate", "dehydrogenase"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0066697", "name": "C0066697#ent", "pos": [14, 15]}}
{"token": ["Sensitivity", "to", "proteolysis", "of", "fast", "and", "slow", "rabbit", "skeletal", "muscle", "myosins", "with", "C0007428#ent", "<e1>", "B", ",", "H", "and", "L", "and", "with", "C0006784#ent", "<e2>", "II", "was", "studied", "in", "various", "incubation", "conditions", "."], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [21, 22]}}
{"token": ["Muscles", "of", "YAH-bearing", "rats", "also", "showed", "small", "increases", "(", "30", "-", "40", "%", ")", "in", "mRNA", "for", "C0007428#ent", "<e1>", "D", ",", "but", "not", "for", "C0006784#ent", "<e2>", "heat", "shock", "protein", "70"], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [24, 25]}}
{"token": ["RNAi-induced", "knockdown", "of", "C1825705#ent", "<e1>", "expression", "inhibited", "cell", "cycle", "because", "cells", "assembled", "C1336688#ent", "<e2>"], "h": {"id": "C1825705", "name": "C1825705#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336688", "name": "C1336688#ent", "pos": [12, 13]}}
{"token": ["The", "treatment", "included", "a", "30-day", "therapy", "with", "C0000598#ent", "<e1>", "(", "in", "addition", "to", "aspirin", ",", "metoprolol", ",", "C0072973#ent", "<e2>", ",", "amlodipine", "and", "nitrates", ")", "."], "h": {"id": "C0000598", "name": "C0000598#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072973", "name": "C0072973#ent", "pos": [17, 18]}}
{"token": ["However", ",", "there", "were", "no", "significant", "differences", "in", "24-h", "and", "awake", "C1705296#ent", "<e1>", "reduction", "between", "2.5", "and", "5", "mg", "C0055724#ent", "<e2>", "after", "single-", "and", "repeat-dose", "administrations", "."], "h": {"id": "C1705296", "name": "C1705296#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0055724", "name": "C0055724#ent", "pos": [19, 20]}}
{"token": ["Prednisolone", "and", "C1881373#ent", "<e1>", "were", "administered", "to", "C0035012#ent", "<e2>", "rats", "and", "the", "changes", "in", "the", "mechanical", "properties", "and", "thermal", "behavior", "the", "skin", "and", "tendon", "of", "C0035012#ent", "<e2>", "rats", "were", "studied", "."], "h": {"id": "C1881373", "name": "C1881373#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [7, 8]}}
{"token": ["C0065488#ent", "<e1>", "was", "heat-stable", ",", "inactivated", "by", "C0764105#ent", "<e2>", ",", "partially", "inactivated", "by", "trypsin", "and", "not", "affected", "by", "neuraminidase", "."], "h": {"id": "C0065488", "name": "C0065488#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0764105", "name": "C0764105#ent", "pos": [7, 8]}}
{"token": ["Alternatively", ",", "it", "is", "possible", "that", "another", "susceptibility", "gene", "linked", "to", "these", "C1706649#ent", "<e1>", "exists", "within", "the", "C0024518#ent", "<e2>"], "h": {"id": "C1706649", "name": "C1706649#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [17, 18]}}
{"token": ["The", "results", "show", "that", ",", "in", "addition", "to", "associations", "with", "the", "C1706649#ent", "<e1>", "at", "least", "two", "additional", "genetic", "effects", "present", "within", "the", "major", "C0024518#ent", "<e2>"], "h": {"id": "C1706649", "name": "C1706649#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [23, 24]}}
{"token": ["C0600438#ent", "<e1>", "AG1478", ",", "an", "EGFR", "tyrosine", "kinase", "inhibitor", "blocks", "ALP-induced", "C1334474#ent", "<e2>", "not", "EGFR", "internalization", "."], "h": {"id": "C0600438", "name": "C0600438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [11, 12]}}
{"token": ["The", "catalytic", "subunit", "DNA-dependent", "protein", "kinase", "C1528018#ent", "<e1>", ")", ",", "encoded", "by", "C1335262#ent", "<e2>", ",", "is", "one", "such", "protein", "."], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335262", "name": "C1335262#ent", "pos": [12, 13]}}
{"token": ["C1707170#ent", "<e1>", "and", "CMY", "cells", "(", "differentiated", "cell", "lines", "expressed", "C1332714#ent", "<e2>", ",", "but", "CMS", "and", "CTS", "cells", "poorly", "differentiated", "cell", "lines", "did", "not", "."], "h": {"id": "C1707170", "name": "C1707170#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332714", "name": "C1332714#ent", "pos": [10, 11]}}
{"token": ["C0151861#ent", "<e1>", "in", "hepatocellular", "carcinoma", "alcoholic", "liver", "disease", "be", "different", "from", "that", "in", "C0267792#ent", "<e2>", "often", "associated", "with", "uroporphyrinuria", "as", "well", "as", "coproporphyrinuria", "."], "h": {"id": "C0151861", "name": "C0151861#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0267792", "name": "C0267792#ent", "pos": [13, 14]}}
{"token": ["The", "pattern", "and", "time", "sequence", "transaminase", "elevation", "this", "patient", "are", "consistent", "with", "acute", "acetaminophen", "hepatotoxicity", ",", "especially", "since", "zidovudine-induced", "hepatotoxicity", "is", "described", "as", "producing", "C0008370#ent", "<e1>", "rather", "than", "C0267797#ent", "<e2>"], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0267797", "name": "C0267797#ent", "pos": [28, 29]}}
{"token": ["The", "NO", "donor", "s-nitroso-n-acetylpenicillamine", ",", "the", "phosphodiesterase", "V", "antagonist", "zaprinast", "C1428222#ent", "<e1>", ")", "and", "PGI2", "each", "potentiated", "C0087140#ent", "<e2>", "messenger", "RNA", "expression", ",", "an", "index", "of", "initiation", "of", "the", "liver", "regeneration", "cascade", "following", "PHx", "."], "h": {"id": "C1428222", "name": "C1428222#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [17, 18]}}
{"token": ["Using", "purified", "proteins", "we", "studied", "the", "ability", "of", "Syk", ",", "Fyn", ",", "and", "C1412097#ent", "<e1>", "to", "differentiate", "between", "tyrosines", "in", "a", "common", "C1335273#ent", "<e2>", "substrate", ",", "c-Cbl", "."], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335273", "name": "C1335273#ent", "pos": [22, 23]}}
{"token": ["C1412097#ent", "<e1>", "was", "found", "to", "be", "associated", "with", "C1335273#ent", "<e2>", "through", "the", "region", "of", "C1335273#ent", "<e2>", "containing", "amino", "acids", "-", "1009", "."], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335273", "name": "C1335273#ent", "pos": [8, 9]}}
{"token": ["The", "affinity", "between", "DNA", "and", "C1823138#ent", "<e1>", "was", "examined", "by", "C0019873#ent", "<e2>", "competitive", "binding", "assay"], "h": {"id": "C1823138", "name": "C1823138#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019873", "name": "C0019873#ent", "pos": [10, 11]}}
{"token": ["Cardiomyopathy", "was", "attributed", "to", "cardiac", "involvement", "in", "metabolic", "myopathy", "retrospectively", "diagnosed", "upon", "the", "clinical", "presentation", "recurrent", "creatine-kinase", "elevation", "C0001125#ent", "<e1>", ",", "and", "the", "presence", "of", "non-compaction", ",", "frequently", "associated", "with", "C0027868#ent", "<e2>"], "h": {"id": "C0001125", "name": "C0001125#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [30, 31]}}
{"token": ["The", "incidence", "of", "C1264041#ent", "<e1>", "not", "increased", ",", "but", "individuals", "with", "C0015523#ent", "<e2>", "were", "bleeders", "tended", "to", "have", "lower", "levels", "of", "factor", "VIIIc", "von", "Willebrand", "factor", "and", "were", "more", "commonly", "of", "blood", "group", "."], "h": {"id": "C1264041", "name": "C1264041#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015523", "name": "C0015523#ent", "pos": [11, 12]}}
{"token": ["In", "search", "of", "novel", "C0003376#ent", "<e1>", "a", "series", "of", "8-substituted", "C0006644#ent", "<e2>", "prepared", "in", "order", "to", "explore", "their", "in", "vitro", "anticancer", ",", "anti-HIV-1", "and", "antimicrobial", "activities"], "h": {"id": "C0003376", "name": "C0003376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006644", "name": "C0006644#ent", "pos": [10, 11]}}
{"token": ["Nepafenac", "is", "unique", "among", "ophthalmic", "C0003211#ent", "<e1>", "in", "that", "it", "is", "a", "prodrug", "deaminated", "to", "C0961209#ent", "<e2>", ",", "a", "highly", "effective", "non-selective", "cyclooxygenase", "inhibitor"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0961209", "name": "C0961209#ent", "pos": [15, 16]}}
{"token": ["Antisense", "inhibition", "of", "C3814151#ent", "<e1>", "expression", "suppresses", "the", "TGF-beta-induced", "delayed", "p38", "activation", ",", "whereas", "overexpression", "of", "C3814151#ent", "<e1>", "activates", "the", "p38", "MAPK", "C1456388#ent", "<e1>", "."], "h": {"id": "C3814151", "name": "C3814151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1456388", "name": "C1456388#ent", "pos": [22, 23]}}
{"token": ["The", "C3814151#ent", "<e1>", "and", "activates", "MTK1", "(=", "C1456388#ent", "<e2>", ")", ",", "which", "is", "a", "member", "of", "the", "MAPKKK", "family", "kinases", "an", "upstream", "activator", "the", "p38", "MAPK", "cascade"], "h": {"id": "C3814151", "name": "C3814151#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1456388", "name": "C1456388#ent", "pos": [7, 8]}}
{"token": ["CD22", "is", "a", "B", "cell", "membrane", "glycoprotein", ",", "upon", "Ag", "receptor", "engagement", ",", "becomes", "rapidly", "C0033681#ent", "<e1>", "phosphorylated", "and", "associates", "with", "several", "signaling", "molecules", "C1442804#ent", "<e2>", ",", "Syk", ",", "PLCgamma1", ",", "and", "the", "protein-tyrosine", "phosphatase", "SHP-1", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [15, 16]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [24, 25]}}
{"token": ["Some", "of", "these", "drugs", "were", "potent", "inhibitors", "not", "only", "of", "C0033681#ent", "<e1>", "also", "of", "the", "Src", ",", "C1442804#ent", "<e2>", ",", "and", "Fyn", "tyrosine", "kinases"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [17, 18]}}
{"token": ["It", "is", "often", "possible", "to", "positively", "diagnose", "C0022104#ent", "<e1>", "IBS", ")", "based", "on", "a", "combination", "of", "C0231217#ent", "<e2>", "their", "chronic", "nature"], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0231217", "name": "C0231217#ent", "pos": [16, 17]}}
{"token": ["Changes", "in", "C0812313#ent", "<e1>", "mRNA", "accumulation", "and", "C1334895#ent", "<e2>", "dephosphorylation", "were", "accompained", "by", "accumulation", "of", "cells", "in", "G1", "phase", "the", "cell", "cycle"], "h": {"id": "C0812313", "name": "C0812313#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334895", "name": "C1334895#ent", "pos": [7, 8]}}
{"token": ["Deficiency", "of", "arylsulfatase", "A", "C0007804#ent", "<e1>", ")", "causes", "the", "C3899988#ent", "<e2>", "metachromatic", "leukodystrophy", "MLD", ")", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}}
{"token": ["The", "major", "Xenopus", "c-Myc", "transcripts", "arise", "from", "sites", "termed", "P1", "and", "C1419693#ent", "<e1>", "similarly", "to", "those", "of", "the", "mammalian", "C0079068#ent", "<e2>"], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [19, 20]}}
{"token": ["We", "investigated", "the", "association", "of", "C1824717#ent", "<e1>", "microsatellite", "and", "RsaI", "T-to-C", "substitution", "in", "the", "C1420276#ent", "<e2>", "the", "risk", "of", "PD", "by", "a", "case-control", "study"], "h": {"id": "C1824717", "name": "C1824717#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [14, 15]}}
{"token": ["Liver", "receptor", "homologue-1", "C1418214#ent", "<e1>", ",", "designated", "NR5A2", ")", "is", "a", "mammalian", "C1334043#ent", "<e2>", "of", "Drosophila", "fushi", "tarazu", "factor", "dFTZ-F1", ")", "and", "structurally", "belongs", "to", "the", "orphan", "nuclear", "receptor", "superfamily"], "h": {"id": "C1418214", "name": "C1418214#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["C1538046#ent", "<e1>", "could", "markedly", "decrease", "serum", "C1427121#ent", "<e2>", "concentration", "."], "h": {"id": "C1538046", "name": "C1538046#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427121", "name": "C1427121#ent", "pos": [6, 7]}}
{"token": ["alpha", "1-Antitrypsin", "a", "major", "C0030946#ent", "<e1>", "inhibitor", "synthesized", "in", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["The", "major", "C0524928#ent", "<e1>", "containing", "products", "include", "CHClF2", ",", "C1705710#ent", "<e2>", ",", "CH2F2", ",", "and", "CH4", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705710", "name": "C1705710#ent", "pos": [9, 10]}}
{"token": ["C2680450#ent", "<e1>", "and", "Delta", "encode", "structurally", "related", "C0086376#ent", "<e2>", "in", "D.", "melanogaster", "that", "bind", "within", "a", "common", "extracellular", "region", "the", "NOTCH", "receptor", "molecule"], "h": {"id": "C2680450", "name": "C2680450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}}
{"token": ["Six", "late", "dumping", "patients", "with", "C0011860#ent", "<e1>", "were", "orally", "administered", "alpha-glucosidase", "inhibitor", "C0050393#ent", "<e2>", "(", "50", "or", "100", "mg", ")", ",", "three", "times", "a", "day", "before", "each", "meal", "for", "1", "month", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0050393", "name": "C0050393#ent", "pos": [12, 13]}}
{"token": ["Many", "studies", "in", "experimental", "animals", "healthy", "volunteers", "patients", "with", "non-insulin-dependent", "diabetes", "mellitus", "C0011860#ent", "<e1>", ")", "have", "shown", "that", "C0050393#ent", "<e2>", "decreases", "postprandial", "blood", "glucose", "with", "a", "lesser", "reduction", "of", "fasting", "blood", "glucose", "plasma", "triglycerides", "postprandial", "insulin", "levels"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0050393", "name": "C0050393#ent", "pos": [18, 19]}}
{"token": ["This", "study", "evaluated", "the", "addition", "of", "sodium", "bicarbonate", "C0074722#ent", "<e1>", ")", "and/or", "clonidine", "to", "C0025384#ent", "<e2>", "for", "performing", "the", "block", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025384", "name": "C0025384#ent", "pos": [14, 15]}}
{"token": ["Ultrasound", "studies", "frequently", "requested", "for", "the", "work-up", "of", "patients", "with", "local", "elbow", "pain", "which", "is", "generally", "caused", "by", "C0035127#ent", "<e1>", "trauma", ",", "inflammatory", "diseases", "or", "C0442874#ent", "<e2>", "."], "h": {"id": "C0035127", "name": "C0035127#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [25, 26]}}
{"token": ["The", "aneugenic", "potential", "of", "C0031923#ent", "<e1>", "nitrate", ",", "an", "C0002062#ent", "<e2>", "as", "an", "ophthalmic", "solution", "screened", "by", "chromosome", "analysis", "in", "the", "bone", "marrow", "cells", "mice", "."], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [9, 10]}}
{"token": ["The", "paste", "was", "found", "to", "contain", "significant", "amounts", "of", "C0031923#ent", "<e1>", "and", "other", "imidazole", "alkaloids", "but", "had", "a", "slightly", "different", "C0002062#ent", "<e2>", "profile", "than", "the", "leaf", "extract"], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [20, 21]}}
{"token": ["Most", "patients", "with", "C0149521#ent", "<e1>", "during", "clinical", "remission", "39", "out", "of", "43", ")", "had", "C0699918#ent", "<e2>", "either", "within", "(", "n", "=", "24", ")", "or", "below", "(", "n", "=", "15", ")", "the", "control", "range"], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [14, 15]}}
{"token": ["Comparison", "of", "kinetic", "constants", "among", "the", "monkey", "kidney", "and", "C0219300#ent", "<e1>", "several", "mammalian", "tissues", "indicated", "that", "dimeric", "dihydrodiol", "dehydrogenase", "C0002003#ent", "<e2>", "higher", "catalytic", "efficiency", "for", "3DG", "than", "did", "aldehyde", "reductase", "carbonyl", "reductase", "and", "monomeric", "dihydrodiol", "dehydrogenase"], "h": {"id": "C0219300", "name": "C0219300#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002003", "name": "C0002003#ent", "pos": [19, 20]}}
{"token": ["Alignment", "of", "the", "amino", "acid", "sequence", "C0219300#ent", "<e1>", "with", "other", "known", "and", "C0002003#ent", "<e2>", "that", "it", "defines", "a", "subfamily", "within", "the", "aldo-keto", "reductase", "superfamily"], "h": {"id": "C0219300", "name": "C0219300#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002003", "name": "C0002003#ent", "pos": [12, 13]}}
{"token": ["FLAG-tagged", "C1538659#ent", "<e1>", "was", "co-immunoprecipitated", "with", "endogenous", "C1366777#ent", "<e2>", "from", "HEK293", "cell", "lysate", "and", "in", "vitro", "binding", "assay", "the", "deletion", "mutants", "of", "C1366777#ent", "<e2>", "showed", "that", "C1538659#ent", "<e1>", "directly", "binds", "to", "the", "TRAF", "domain", "C1366777#ent", "<e2>", "."], "h": {"id": "C1538659", "name": "C1538659#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1366777", "name": "C1366777#ent", "pos": [7, 8]}}
{"token": ["It", "is", "concluded", "that", "Peganum", "harmala", "its", "C0949738#ent", "<e1>", "could", "probably", "be", "used", "for", "the", "control", "of", "antibiotic", "resistant", "C1875400#ent", "<e2>", "of", "bacteria", "as", "well", "as", "protozoa", "."], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [19, 20]}}
{"token": ["The", "strains", "classified", "as", "A.", "japonicus", "produced", "C0949738#ent", "<e1>", "a", "polar", "metabolite", "while", "the", "A.", "aculeatus", "C1875400#ent", "<e2>", "produced", "neoxaline", ",", "okaramins", ",", "paraherquamidelike", "compounds", ",", "and", "secalonic", "acid"], "h": {"id": "C0949738", "name": "C0949738#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [16, 17]}}
{"token": ["We", "here", "report", "on", "a", "Japanese", "family", "with", "congenital", "fibrosis", "the", "extraocular", "muscles", "C1302995#ent", "<e1>", ")", "syndrome", "associated", "with", "progressive", "C0007758#ent", "<e2>"], "h": {"id": "C1302995", "name": "C1302995#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [20, 21]}}
{"token": ["These", "electron", "microscopy", "findings", "could", "be", "considered", "as", "a", "peculiar", "feature", "of", "C0037231#ent", "<e1>", "patients", "with", "C0012772#ent", "<e2>", "."], "h": {"id": "C0037231", "name": "C0037231#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012772", "name": "C0012772#ent", "pos": [16, 17]}}
{"token": ["The", "C0013227#ent", "<e1>", "and", "metabolite", "were", "extracted", "by", "liquid-liquid", "extraction", "C3495432#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3495432", "name": "C3495432#ent", "pos": [10, 11]}}
{"token": ["The", "isoprenaline-induced", "decrease", "in", "the", "density", "of", "cell", "surface", "muscarinic", "receptors", "not", "be", "simulated", "by", "C0917964#ent", "<e1>", "and", "was", "not", "abolished", "by", "the", "protein", "kinase", "A", "inhibitors", "Rp-cAMPS", "C0062067#ent", "<e2>", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0062067", "name": "C0062067#ent", "pos": [28, 29]}}
{"token": ["C0010980#ent", "<e1>", ",", "recently", "brought", "into", "the", "C0032453#ent", "<e2>", "treatment", "have", "not", "superseded", "cortico-steroid", "therapy"], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0032453", "name": "C0032453#ent", "pos": [7, 8]}}
{"token": ["The", "fourth", "child", "had", "low-grade", "trisomy", "21", "in", "blood", ",", "with", "minimal", "signs", "of", "C0013080#ent", "<e1>", "with", "bilateral", "C0018777#ent", "<e2>"], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0018777", "name": "C0018777#ent", "pos": [18, 19]}}
{"token": ["One", "child", "from", "the", "cryopreserved", "embryo", "group", "C0013080#ent", "<e1>", "three", "had", "squints", ",", "and", "four", "had", "C0018777#ent", "<e2>", "in", "the", "control", "children", "six", "had", "squints", ",", "and", "nine", "had", "C0018777#ent", "<e2>"], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0018777", "name": "C0018777#ent", "pos": [16, 17]}}
{"token": ["At", "the", "M\u00e1xima", "Medisch", "Centrum", "in", "Veldhoven", ",", "The", "Netherlands", ",", "neonatal", "C0243026#ent", "<e1>", "caused", "by", "invasive", "C0032269#ent", "<e2>", "diagnosed", "in", "5", "neonates", "between", "1996", "and", "2004", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0032269", "name": "C0032269#ent", "pos": [17, 18]}}
{"token": ["In", "242", "patients", "with", "hypertension", "and/or", "C0002962#ent", "<e1>", "a", "new", "cardioselective", "betablocker", "ISA", ",", "C0053799#ent", "<e2>", "(", "Concor", ")", ",", "was", "tested", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0053799", "name": "C0053799#ent", "pos": [14, 15]}}
{"token": ["The", "inhibitory", "effect", "Src", "depends", "on", "a", "detergent-resistant", "membrane-anchored", "C1332794#ent", "<e1>", "and", "co-localization", "of", "all", "components", "of", "the", "C1420705#ent", "<e2>", "membrane", "microdomains"], "h": {"id": "C1332794", "name": "C1332794#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420705", "name": "C1420705#ent", "pos": [18, 19]}}
{"token": ["In", "animals", "refed", "after", "20", "days", "of", "C0162429#ent", "<e1>", ",", "network", "size", "reduced", ",", "as", "did", "the", "GC", ":", "C3811118#ent", "<e2>", "ratio", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [19, 20]}}
{"token": ["AUH", "protein", "exhibits", "an", "C0295398#ent", "<e1>", "RNA-binding", "property", "and", "an", "intrinsic", "C0014314#ent", "<e2>", "and", "may", "therefore", "function", "to", "link", "mRNA", "decay", "to", "metabolic", "processes", "."], "h": {"id": "C0295398", "name": "C0295398#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014314", "name": "C0014314#ent", "pos": [11, 12]}}
{"token": ["The", "amino", "acid", "sequence", "C0295398#ent", "<e1>", "Acinetobacter", "sp.", "found", "to", "be", "related", "to", "over", "100", "C0014314#ent", "<e2>", "up", "to", "50", "%", "identity", ")", ",", "possibly", "all", "being", "3-methylglutaconyl-CoA", "hydratases", "."], "h": {"id": "C0295398", "name": "C0295398#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014314", "name": "C0014314#ent", "pos": [15, 16]}}
{"token": ["Local", "C0543495#ent", "<e1>", "significantly", "decreased", "the", "wheal", "volume", "induced", "by", "intradermal", "prostaglandin", "E", "C1537501#ent", "<e2>", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [13, 14]}}
{"token": ["The", "diagnosis", "of", "C1412290#ent", "<e1>", "must", "be", "considered", "in", "the", "differential", "diagnosis", "patients", "presenting", "with", "C0035078#ent", "<e2>", "with", "a", "history", "of", "recurrent", "nephrolithiasis", "."], "h": {"id": "C1412290", "name": "C1412290#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [15, 16]}}
{"token": ["Whether", "this", "occurs", "via", "a", "direct", "interaction", "between", "C1705380#ent", "<e1>", "and", "cis", "elements", "associated", "with", "target", "C1417679#ent", "<e2>", "is", "unclear", ",", "partly", "because", "the", "definitive", "characteristics", "of", "a", "C1705380#ent", "<e1>", "binding", "site", "not", "been", "identified", "."], "h": {"id": "C1705380", "name": "C1705380#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["We", "confirmed", "the", "C1947941#ent", "<e1>", "to", "be", "pregnancy-associated", "plasma", "protein", "A", "C2984583#ent", "<e2>", ")", "by", "immunoblotting", "with", "an", "antibody", "against", "human", "PAPP-A/proMBP", "(", "pro", "form", "of", "eosinophil", "major", "basic", "protein", ")", "complex", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2984583", "name": "C2984583#ent", "pos": [11, 12]}}
{"token": ["We", "confirmed", "the", "C1947941#ent", "<e1>", "to", "be", "C2984583#ent", "<e2>", "PAPP-A", ")", "by", "immunoblotting", "with", "an", "antibody", "against", "human", "PAPP-A/proMBP", "(", "pro", "form", "of", "eosinophil", "major", "basic", "protein", ")", "complex", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2984583", "name": "C2984583#ent", "pos": [7, 8]}}
{"token": ["In", "summary", ",", "C0537674#ent", "<e1>", "is", "a", "highly", "potent", "and", "selective", "C3850093#ent", "<e2>"], "h": {"id": "C0537674", "name": "C0537674#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3850093", "name": "C3850093#ent", "pos": [11, 12]}}
{"token": ["Latent", "membrane", "protein", "2A", "C1328049#ent", "<e1>", ")", "is", "a", "C0079405#ent", "<e2>", "expressed", "during", "Epstein-Barr", "virus", "EBV", ")", "latency", "in", "EBV-infected", "B", "cells", "both", "in", "cell", "culture", "in", "vivo"], "h": {"id": "C1328049", "name": "C1328049#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079405", "name": "C0079405#ent", "pos": [9, 10]}}
{"token": ["We", "observed", "that", "most", "cell", "types", "to", "p38", "C0752312#ent", "<e1>", "inhibition", "with", "diminished", "C0948245#ent", "<e2>", "but", "that", "this", "treatment", "induced", "increased", "C0948245#ent", "<e2>", "macrophages", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0948245", "name": "C0948245#ent", "pos": [13, 14]}}
{"token": ["This", "is", "correlated", "with", "the", "dissociation", "of", "newly", "synthesized", "large", "C0599220#ent", "<e1>", "from", "the", "29S", "large", "C1335531#ent", "<e2>"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335531", "name": "C1335531#ent", "pos": [16, 17]}}
{"token": ["Finally", ",", "in", "human", "breast", "carcinomas", "C1705046#ent", "<e1>", "is", "sometimes", "present", "in", "cytoplasmic", "foci", "positive", "for", "FMRP", "and", "C1442738#ent", "<e2>", ",", "suggesting", "that", "SGs", "formation", "occurs", "in", "malignant", "tumours"], "h": {"id": "C1705046", "name": "C1705046#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1442738", "name": "C1442738#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "reveal", "a", "role", "for", "C1419939#ent", "<e1>", "and", "HRD1", "in", "C1706005#ent", "<e2>", "quality", "control"], "h": {"id": "C1419939", "name": "C1419939#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [11, 12]}}
{"token": ["Renal", "disease", "C0021847#ent", "<e1>", ",", "lymphoma", ",", "and", "C1527336#ent", "<e2>", "or", "without", "mixed", "cryoglobulinemia", "all", "strongly", "associated", "with", "HCV", "infection"], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [8, 9]}}
{"token": ["In", "vitro", "C1414369#ent", "<e1>", "treatment", "of", "permeabilized", "sciatic", "nerve", "showed", "the", "same", "specificity", ",", "i.e.", "NFH", "and", "C1826396#ent", "<e2>", "are", "the", "only", "proteins", "that", "reacted", "with", "C1414369#ent", "<e1>", ",", "providing", "they", "are", "phosphorylated", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414369", "name": "C1414369#ent", "pos": [2, 3]}}
{"token": ["C0027203#ent", "<e1>", "concentration", "in", "patients", "with", "C0340288#ent", "<e2>", "the", "same", "(", "even", "during", "exercise", ")", "as", "seen", "in", "the", "patients", "without", "ischaemic", "heart", "disease"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [6, 7]}}
{"token": ["C0022575#ent", "<e1>", "128", "was", "approximately", "10", "times", "more", "potent", "than", "C0056506#ent", "<e2>", "for", "each", "agonist.6", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0056506", "name": "C0056506#ent", "pos": [10, 11]}}
{"token": ["C1142644#ent", "<e1>", "recognized", "two", "major", "C1305923#ent", "<e2>", "with", "apparent", "molecular", "weights", "radioactive", "64", "K", "and", "inactive", "28", "K", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [5, 6]}}
{"token": ["In", "this", "report", "we", "present", "a", "66-year-old", "patient", "with", "active", "enterococcal", "aortic", "native", "C0340359#ent", "<e1>", "with", "a", "history", "of", "gastric", "ulcers", "with", "C0000737#ent", "<e2>", "to", "splenic", "infarction"], "h": {"id": "C0340359", "name": "C0340359#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [22, 23]}}
{"token": ["The", "two", "conditions", "most", "commonly", "associated", "with", "nephrocalcinosis", "in", "childhood", "are", "the", "use", "of", "C0016860#ent", "<e1>", "in", "infancy", "and", "the", "treatment", "of", "patients", "with", "C3536983#ent", "<e2>", "phosphate", "and", "vitamin", "D", "preparations", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3536983", "name": "C3536983#ent", "pos": [24, 25]}}
{"token": ["One", "hundred", "and", "nine", "samples", "comprising", "carcinomas", ",", "adenomas", ",", "dysplastic", ",", "inflamed", "and", "normal", "mucosa", "patients", "with", "sporadic", "colon", "cancer", "C0009324#ent", "<e1>", "UC", ")", "were", "analysed", "for", "C0079973#ent", "<e2>", "mutations", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0079973", "name": "C0079973#ent", "pos": [28, 29]}}
{"token": ["During", "the", "morning", "activities", "C0033237#ent", "<e1>", "stable", ",", "while", "C0030306#ent", "<e2>", "to", "increase", "."], "h": {"id": "C0033237", "name": "C0033237#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [9, 10]}}
{"token": ["C0084304#ent", "<e1>", "DNA", "helicases", "defined", "as", "proteins", "sharing", "a", "homologous", "region", "Escherichia", "coli", "C0084304#ent", "<e1>", "and", "are", "basically", "regarded", "as", "enzymes", "involved", "in", "recombination", "."], "h": {"id": "C0084304", "name": "C0084304#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0084304", "name": "C0084304#ent", "pos": [0, 1]}}
{"token": ["The", "C0084304#ent", "<e1>", "DNA", "helicases", "of", "particular", "interest", "since", "several", "human", "C0084304#ent", "<e1>", "defective", "in", "diseases", "associated", "with", "premature", "aging", "cancer", "."], "h": {"id": "C0084304", "name": "C0084304#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0084304", "name": "C0084304#ent", "pos": [1, 2]}}
{"token": ["It", "is", "concluded", "that", "C0850666#ent", "<e1>", "positive", "gastritis", "rare", ",", "while", "C0850666#ent", "<e1>", "negative", "gastritis", "relatively", "common", "in", "patients", "with", "C0010346#ent", "<e1>"], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [20, 21]}}
{"token": ["This", "study", "was", "undertaken", "to", "determine", "the", "prevalence", "of", "chronic", "gastritis", "C0850666#ent", "<e1>", "patients", "with", "C0010346#ent", "<e2>"], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [15, 16]}}
{"token": ["C0019202#ent", "<e1>", "an", "11-year-old", "girl", "with", "generalized", "weakness", "C1145670#ent", "<e2>", "reported", "."], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [8, 9]}}
{"token": ["It", "is", "known", "that", "the", "treatment", "of", "adults", "with", "C0011522#ent", "<e1>", "and", "RNases", "offers", "protection", "from", "viral", "and", "C0004623#ent", "<e2>"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [18, 19]}}
{"token": ["Persistence", "of", "activated", "B", "cells", "periods", "with", "clinically", "quiescent", "disease", "in", "C0014060#ent", "<e1>", "seems", "to", "underly", "C0020455#ent", "<e2>", "but", "not", "anti-dsDNA", "production", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020455", "name": "C0020455#ent", "pos": [16, 17]}}
{"token": ["Systemic", "lupus", "erythematosus", "C0014060#ent", "<e1>", ")", "is", "a", "multigenic", "disease", "associated", "with", "C0020455#ent", "<e2>", "IgG", "anti-nuclear", "antibodies", "immune", "complex", "glomerulonephritis", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020455", "name": "C0020455#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "C0021246#ent", "<e1>", "did", "not", "affect", "NPY-", "and", "C1826747#ent", "<e2>", "-", "36-induced", "alterations", "of", "systemic", "and", "renovascular", "hemodynamics", "completely", "abolished", "NPY-", "and", "C1826747#ent", "<e2>", "-", "36-induced", "diuresis", "and", "natriuresis", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826747", "name": "C1826747#ent", "pos": [9, 10]}}
{"token": ["Exogenously", "administered", "PGE1", "or", "PGE2", ",", "like", "C0004259#ent", "<e1>", ",", "markedly", "decreased", "both", "the", "flow", "and", "C2936886#ent", "<e2>", "concentration", "of", "parasympathetically", "evoked", "rat", "parotid", "saliva", ";", "PGF2", "alpha", "less", "effective", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "carbachol", "on", "the", "release", "of", "[14C]arachidonic", "acid", "was", "blocked", "by", "C0004259#ent", "<e1>", "and", "the", "exclusion", "of", "C2936886#ent", "<e2>", "from", "the", "incubation", "media"], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [19, 20]}}
{"token": ["Meckel-Gruber", "syndrome", "MKS", ")", ",", "C0687120#ent", "<e1>", "(", "NPHP", ")", ",", "and", "C1842577#ent", "<e2>", "JBTS", ")", "are", "a", "group", "of", "heterogeneous", "cystic", "kidney", "disorders", "partially", "overlapping", "loci", "."], "h": {"id": "C0687120", "name": "C0687120#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C1842577", "name": "C1842577#ent", "pos": [12, 13]}}
{"token": ["As", "it", "was", "shown", "to", "be", "the", "endogenous", "ligand", "for", "the", "mammalian", "orphan", "G-protein-coupled", "receptor", "C1540171#ent", "<e1>", ",", "now", "renamed", "the", "UT", "receptor", "interest", "in", "C1421413#ent", "<e2>", "physiology", "has", "grown", "."], "h": {"id": "C1540171", "name": "C1540171#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1421413", "name": "C1421413#ent", "pos": [25, 26]}}
{"token": ["However", ",", "only", "C1421413#ent", "<e1>", "was", "capable", "to", "increase", "the", "cellular", "Ca(2", "+", ")", ",", "suggesting", "different", "mechanism", "of", "C1540171#ent", "<e2>", "activation", "by", "guanylin", "peptides", "and", "C1421413#ent", "<e1>", "."], "h": {"id": "C1540171", "name": "C1540171#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1421413", "name": "C1421413#ent", "pos": [3, 4]}}
{"token": ["We", "have", "now", "demonstrated", "that", "C1540171#ent", "<e1>", "is", "a", "high", "affinity", "receptor", "C1421413#ent", "<e2>", "and", "designate", "it", "UII-R1a", "."], "h": {"id": "C1540171", "name": "C1540171#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421413", "name": "C1421413#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "C0525678#ent", "<e1>", "mesylate", ",", "an", "irreversible", "monoamine", "oxidase", "type", "B", "inhibitor", "improves", "symptoms", "of", "early", "C0030567#ent", "<e2>", "PD", ")", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [17, 18]}}
{"token": ["Recent", "reports", "on", "stimulatory", "effects", "therapeutic", "doses", "C0008809#ent", "<e1>", "on", "bone", "marrow", "myeloid", "progenitor", "cells", "irradiated", ",", "C0027947#ent", "<e2>", "warrant", "further", "investigations", "in", "experimental", "animals", "well", "as", "in", "neutropenic", "and", "bone", "marrow", "transplant", "patients", "treated", "with", "new", "quinolones", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [17, 18]}}
{"token": ["We", "examined", "the", "efficacy", "of", "C0008809#ent", "<e1>", "as", "an", "empirical", "treatment", "fever", "in", "97", "C0027947#ent", "<e2>", "patients", "in", "a", "randomized", "study", "C0008809#ent", "<e1>", "and", "benzylpenicillin", "versus", "netilmicin", "and", "piperacillin", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [14, 15]}}
{"token": ["C0008809#ent", "<e1>", "appears", "to", "be", "effective", "for", "preventing", "bacterial", "infections", "C0027947#ent", "<e2>", "patients", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [10, 11]}}
{"token": ["The", "antirepressor", "of", "C1825005#ent", "<e1>", "is", "not", "cleaved", "by", "C1419240#ent", "<e2>"], "h": {"id": "C1825005", "name": "C1825005#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419240", "name": "C1419240#ent", "pos": [9, 10]}}
{"token": ["These", "findings", "suggest", "that", "C0235480#ent", "<e1>", "may", "account", "for", "the", "late", "eosinophilia", "but", "not", "for", "the", "acute", "phase", "the", "rat", "C0032231#ent", "<e2>", "which", "is", "clearly", "attenuated", "by", "C0235480#ent", "<e1>", "or", "ECF-A", "pretreatment", "."], "h": {"id": "C0032231", "name": "C0032231#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [4, 5]}}
{"token": ["In", "patients", "with", "light-chain", "(", "AL", ")", "C0002726#ent", "<e1>", ",", "acquired", "hemostatic", "abnormalities", "including", "C0272315#ent", "<e2>", "hyperfibrinolysis", ",", "and", "platelet", "dysfunction", "can", "be", "regarded", "as", "the", "most", "important", "pathogenetic", "factors"], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0272315", "name": "C0272315#ent", "pos": [14, 15]}}
{"token": ["These", "results", "extend", "the", "range", "of", "C2364020#ent", "<e1>", "to", "express", "rat", "C1412114#ent", "<e2>"], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412114", "name": "C1412114#ent", "pos": [11, 12]}}
{"token": ["Metabolic", "acidosis", "by", "a", "reduced", "capacity", "of", "the", "kidneys", "to", "excrete", "acid", "contributes", "to", "the", "development", "of", "C0005940#ent", "<e1>", "the", "course", "of", "chronic", "renal", "failure", "may", "be", "associated", "with", "C0005940#ent", "<e1>", "some", "patients", "with", "C0001126#ent", "<e1>"], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001126", "name": "C0001126#ent", "pos": [34, 35]}}
{"token": ["Rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "is", "an", "C0004364#ent", "<e2>", "characterized", "by", "a", "persistent", "inflammation", "of", "the", "synovium", ",", "leading", "to", "the", "erosion", "of", "articular", "cartilage", "bone", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [7, 8]}}
{"token": ["Immunofluorescence", "and", "semi-quantitative", "immunoelectron", "microscopy", "that", "15", "and", "30", "min", "of", "C3273483#ent", "<e1>", "treatment", "resulted", "in", "significant", "reduction", "in", "apical", "plasma", "membrane", "labeling", "C1412492#ent", "<e2>", ",", "with", "a", "concomitant", "increase", "in", "labeling", "of", "vesicles", "and", "multivesicular", "bodies"], "h": {"id": "C3273483", "name": "C3273483#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412492", "name": "C1412492#ent", "pos": [23, 24]}}
{"token": ["PS", "liposomes", "induced", "activation", "of", "C0082529#ent", "<e1>", "ERK", ")", "but", "not", "p38", "mitogen-activated", "protein", "kinase", "C3540050#ent", "<e2>", "independent", "manner", "."], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540050", "name": "C3540050#ent", "pos": [15, 16]}}
{"token": ["Cell", "fractionation", "that", "C3538895#ent", "<e1>", "co-fractionated", "with", "actin", ",", "while", "C1539746#ent", "<e2>", "was", "predominantly", "restricted", "to", "the", "membrane", "fraction"], "h": {"id": "C3538895", "name": "C3538895#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539746", "name": "C1539746#ent", "pos": [10, 11]}}
{"token": ["We", "hypothesized", "that", "the", "combination", "of", "5-HT4", "agonist", "C0027410#ent", "<e1>", "intestinal", "transit", "than", "either", "treatment", "alone", "in", "female", "C0022104#ent", "<e2>", "C-IBS", ")", "patients", "."], "h": {"id": "C0027410", "name": "C0027410#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [18, 19]}}
{"token": ["Naloxone", ",", "an", "C0027410#ent", "<e1>", "appears", "to", "hold", "promise", "in", "patients", "with", "C0022104#ent", "<e2>", "small", "intestinal", "pseudo-obstruction", "and", "constipation", "."], "h": {"id": "C0027410", "name": "C0027410#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [12, 13]}}
{"token": ["However", ",", "in", "the", "presence", "of", "C0812215#ent", "<e1>", ",", "an", "interaction", "between", "Rad24", "and", "C1419281#ent", "<e2>", "was", "inhibited", "in", "triple", "hybrid", "assay", "indicating", "that", "C0812215#ent", "<e1>", "inhibits", "the", "interaction", "between", "Rad24", "and", "C1419281#ent", "<e2>", "."], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419281", "name": "C1419281#ent", "pos": [14, 15]}}
{"token": ["kappa-Casein", "components", "were", "subjected", "to", "calf", "rennin", "chymosin", ";", "EC", "3.4.23.4", "]", ",", "bovine", "trypsin", "EC", "3.4.21.4", ",", "C0764105#ent", "<e1>", "[", "EC", "3.4.21.1", ",", "pronase", "[", "EC", "3.4.24.4", "]", "and", "C0016016#ent", "<e2>", "EC", "3.4.21.7", "]", "."], "h": {"id": "C0764105", "name": "C0764105#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0016016", "name": "C0016016#ent", "pos": [30, 31]}}
{"token": ["It", "remains", "unclear", "whether", "C0151744#ent", "<e1>", "to", "coronary", "microvascular", "dysfunction", "is", "the", "cause", "of", "chest", "pain", "C0039082#ent", "<e2>", "chest", "pain", "ischemic-like", "stress", "ECG", "despite", "angiographically", "normal", "coronary", "arteries", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [16, 17]}}
{"token": ["An", "increasing", "number", "of", "cDNAs", "and", "C1305923#ent", "<e1>", "have", "been", "ascribed", "to", "the", "C1515406#ent", "<e2>", "TGF-beta", ")", "superfamily", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1515406", "name": "C1515406#ent", "pos": [13, 14]}}
{"token": ["The", "C1305923#ent", "<e1>", "of", "the", "C1515406#ent", "<e2>", "TGF-beta", ")", "family", "are", "potent", "endogenous", "immuno-regulators", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1515406", "name": "C1515406#ent", "pos": [5, 6]}}
{"token": ["The", "enzyme", "fraction", "appears", "to", "be", "substantially", "free", "from", "C1415104#ent", "<e1>", "reduced", "glutathione", ",", "and", "C3887669#ent", "<e2>"], "h": {"id": "C1415104", "name": "C1415104#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [15, 16]}}
{"token": ["Other", "C1705341#ent", "<e1>", "inhibitors", ",", "such", "as", "C0064695#ent", "<e2>", "tyrphostin", "RG50864", ",", "also", "inhibited", "the", "Ag-induced", "activation", "of", "C1705341#ent", "<e1>", "and", "histamine", "release", "."], "h": {"id": "C0064695", "name": "C0064695#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [1, 2]}}
{"token": ["The", "authors", "describe", "a", "patient", "who", "developed", "a", "rare", "event", "of", "C0037928#ent", "<e1>", "while", "on", "C0377401#ent", "<e2>", "for", "non-small-cell", "lung", "cancer"], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0377401", "name": "C0377401#ent", "pos": [15, 16]}}
{"token": ["Native", "type", "V", "collagen", "molecules", "mammalian", "C0162745#ent", "<e1>", "but", "are", "cleaved", "by", "certain", "C0172537#ent", "<e2>", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [13, 14]}}
{"token": ["Although", "SCCA2", "inhibits", "serine", "proteinases", "as", "C1413814#ent", "<e1>", "mast", "cell", "chymase", "SCCA1", "targets", "cysteine", "proteinases", "as", "C1413821#ent", "<e2>", "K", ",", "L", ",", "and", "papain", "."], "h": {"id": "C1413814", "name": "C1413814#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413821", "name": "C1413821#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "C1313497#ent", "<e1>", "could", "contribute", "to", "tissue", "remodeling", "inflammation", "characterizing", "C1415692#ent", "<e2>", "."], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [11, 12]}}
{"token": ["In", "vitro", "phosphorylation", "studies", "indicate", "that", "C1415012#ent", "<e1>", "a", "substrate", "for", "both", "C0054846#ent", "<e2>", "protein", "kinase", "C."], "h": {"id": "C1415012", "name": "C1415012#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054846", "name": "C0054846#ent", "pos": [12, 13]}}
{"token": ["The", "C0037274#ent", "<e1>", "polyglandular", "autoimmune", "disease", "PGAD", ")", "type", "1", "(", "previously", "called", "C0006848#ent", "<e2>", "are", "nail", "dystrophy", "vitiligo", ",", "and", "alopecia", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0006848", "name": "C0006848#ent", "pos": [13, 14]}}
{"token": ["Whether", "dopaminergic", "and", "C0242893#ent", "<e1>", "influence", "on", "C0003405#ent", "<e2>", "rest", "and", "postural", "tremor", "a", "subject", "of", "debate", "."], "h": {"id": "C0242893", "name": "C0242893#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [7, 8]}}
{"token": ["In", "conclusion", ",", "C0015837#ent", "<e1>", "in", "asthmatic", "children", "was", "significantly", "decreased", "from", "C0380447#ent", "<e2>", ",", "which", "corroborates", "anti-", "inflammatory", "properties", "of", "LTRA", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0380447", "name": "C0380447#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "rapamycine", "is", "now", "evaluated", "in", "various", "C0029896#ent", "<e1>", "characterized", "by", "cell", "growth", "disorders", "as", "phacomatosis", "and", "autosomal", "dominant", "C0022680#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022680", "name": "C0022680#ent", "pos": [20, 21]}}
{"token": ["In", "the", "present", "study", "we", "have", "studied", "the", "effect", "of", "this", "C0013227#ent", "<e1>", "on", "[3H]diacylglycerol", "and", "[3H]phosphatidic", "acid", "in", "response", "to", "C1705725#ent", "<e2>", "in", "human", "neutrophils", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [21, 22]}}
{"token": ["Estimates", "of", "risk", "of", "Stevens-Johnson", "syndrome", "C2987154#ent", "<e1>", ")", "and", "toxic", "epidermal", "necrolysis", "TEN", ")", "associated", "with", "C0003299#ent", "<e2>", "AEDs", ")", "have", "used", "denominators", "based", "on", "the", "number", "of", "prescriptions", "or", "daily", "doses"], "h": {"id": "C2987154", "name": "C2987154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [17, 18]}}
{"token": ["Efficacy", ",", "pharmacodynamics", "and", "clinical", "pharmacokinetics", "of", "haloperidol", "decanoate", "fluphenazine", "enanthate", "decanoate", ",", "C0055929#ent", "<e1>", "zuclopenthixol", "decanoate", "acutard", ",", "flupenthixol", "decanoate", "perphenazine", "enanthate", "pipothiazine", "palmitate", "undecylenate", ",", "and", "C0016383#ent", "<e2>", "are", "reviewed", "."], "h": {"id": "C0055929", "name": "C0055929#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0016383", "name": "C0016383#ent", "pos": [28, 29]}}
{"token": ["On", "the", "other", "hand", ",", "the", "finding", "of", "inactive", "NC", "(", "calcifications", "without", "hydrocephalus", "and/or", "C0025287#ent", "<e1>", "in", "patients", "with", "C0018681#ent", "<e2>", "is", "probably", "fortuitous", "in", "most", "cases", "."], "h": {"id": "C0025287", "name": "C0025287#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [20, 21]}}
{"token": ["Meningitis", "should", "be", "suspected", "in", "a", "patient", "who", "presents", "with", "fever", ",", "C0025287#ent", "<e1>", ",", "or", "severe", "C0018681#ent", "<e2>", "."], "h": {"id": "C0025287", "name": "C0025287#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [17, 18]}}
{"token": ["C1334126#ent", "<e1>", "oligomerization", "was", "also", "studied", "by", "coimmunoprecipitation", "of", "green", "fluorescent", "protein-", "V5-tagged", "C1334126#ent", "<e1>", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334126", "name": "C1334126#ent", "pos": [0, 1]}}
{"token": ["Comparison", "of", "the", "effects", "of", "C0056789#ent", "<e1>", "to", "those", "of", "the", "holoprosencephaly-inducing", "cholesterol", "synthesis", "inhibitor", "C0004465#ent", "<e2>", "shows", "that", "C0056789#ent", "<e1>", "does", "not", "induce", "malformations", "by", "interfering", "with", "cholesterol", "metabolism"], "h": {"id": "C0056789", "name": "C0056789#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004465", "name": "C0004465#ent", "pos": [15, 16]}}
{"token": ["Both", "the", "C0919336#ent", "<e1>", "inhibitor", "BB3103", "and", "the", "NO", "inhibitor", "LNAM", "effectively", "decreased", "C1822723#ent", "<e2>", "apoptosis", ",", "suggesting", "a", "separate", "role", "of", "MMPs", "and", "NO", "in", "hypoxia-reoxygenation-induced", "C1822723#ent", "<e2>", "apoptosis", "."], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1822723", "name": "C1822723#ent", "pos": [13, 14]}}
{"token": ["Rule", "out", "C1692886#ent", "<e1>", "in", "a", "patient", "with", "an", "established", "diagnosis", "of", "C0003872#ent", "<e2>", "especially", "if", "the", "presentation", "is", "monarticular", "."], "h": {"id": "C1692886", "name": "C1692886#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [12, 13]}}
{"token": ["The", "sequence", "was", "found", "to", "encode", "a", "small", "C1427594#ent", "<e1>", "the", "Ras", "family", "highest", "homology", "to", "the", "C1335596#ent", "<e2>", "Dexras1", "."], "h": {"id": "C1427594", "name": "C1427594#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335596", "name": "C1335596#ent", "pos": [17, 18]}}
{"token": ["C0008402#ent", "<e1>", "treatment", "further", "shortened", "the", "C0720099#ent", "<e2>", "of", "diarrhea", "without", "adverse", "effects", "those", "children", "who", "had", "received", "ORS-WHO", "and", "thus", "were", "properly", "rehydrated", "."], "h": {"id": "C0008402", "name": "C0008402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [6, 7]}}
{"token": ["When", "cells", "were", "C0275524#ent", "<e1>", "with", "both", "recombinants", "C1413882#ent", "<e2>", "was", "processed", "to", "its", "lower", "molecular", "weight", "forms"], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413882", "name": "C1413882#ent", "pos": [8, 9]}}
{"token": ["The", "use", "of", "trypsin", "in", "1,1,1,3,3,3-hexafluoro-2-propanol", "(", "C3273420#ent", "<e1>", ")", "paired", "with", "N", ",", "C0066373#ent", "<e2>", "(", "DMF", ")", "has", "been", "proposed", "for", "the", "enzymatic", "condensation", "of", "peptides", "."], "h": {"id": "C3273420", "name": "C3273420#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0066373", "name": "C0066373#ent", "pos": [14, 15]}}
{"token": ["In", "patients", "with", "a", "C0027726#ent", "<e1>", "administration", "of", "C0032950#ent", "<e2>", "causes", "an", "increase", "of", "proteinuria", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [8, 9]}}
{"token": ["C0023374#ent", "<e1>", "production", "of", "adenosine", "by", "C1412291#ent", "<e2>", "activity", "were", "also", "examined", "."], "h": {"id": "C0023374", "name": "C0023374#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412291", "name": "C1412291#ent", "pos": [6, 7]}}
{"token": ["The", "first", ",", "a", "White", "woman", "aged", "34", "years", ",", "was", "found", "to", "have", "C2698898#ent", "<e1>", "after", "receiving", "first", "C0006790#ent", "<e2>", "and", "then", "oxymetholone", "for", "a", "total", "period", "of", "7", "years", "."], "h": {"id": "C2698898", "name": "C2698898#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006790", "name": "C0006790#ent", "pos": [19, 20]}}
{"token": ["An", "immunogenic", ",", "recombinant", "protein", "the", "fungal", "respiratory", "pathogen", "Coccidioides", "posadasii", "was", "previously", "identified", "as", "a", "beta-1,3-glucanosyltransferase", "homolog", "C3273599#ent", "<e1>", ")", "and", "shown", "to", "confer", "protection", "to", "C57BL/6", "mice", "C0009186#ent", "<e2>", "."], "h": {"id": "C3273599", "name": "C3273599#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [29, 30]}}
{"token": ["In", "a", "three-month", ",", "double-masked", ",", "randomized", "clinical", "trial", "we", "evaluated", "the", "once-daily", "ocular", "hypotensive", "efficacy", "of", "0.25", "%", "C0006388#ent", "<e1>", "and", "0.25", "%", "timolol", "in", "80", "patients", "with", "C0339573#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0006388", "name": "C0006388#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [29, 30]}}
{"token": ["Data", "from", "two", "short-term", "double-masked", "studies", "24", "and", "16", "subjects", "suggest", "that", "topically", "applied", "C0006388#ent", "<e1>", "safely", "and", "effectively", "treats", "C0339573#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0006388", "name": "C0006388#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [20, 21]}}
{"token": ["C1176020#ent", "<e1>", "potently", "inhibited", "the", "enzyme", "activity", "both", "C3831543#ent", "<e2>", "AMPK", ")", "and", "the", "ribosomal", "S6", "kinase", "RSK1", "at", "therapeutically", "relevant", "concentrations", "."], "h": {"id": "C1176020", "name": "C1176020#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3831543", "name": "C3831543#ent", "pos": [8, 9]}}
{"token": ["C0003015#ent", "<e1>", "interact", "with", "diuretics", ",", "lithium", ",", "nonsteroidal", "anti-inflammatory", "drugs", "C0359086#ent", "<e2>", "and", "some", "other", "drugs", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0359086", "name": "C0359086#ent", "pos": [11, 12]}}
{"token": ["STUDY", "OBJECTIVE0", "-", "-he", "C3890193#ent", "<e1>", "was", "to", "explore", "the", "cellular", "mechanisms", "for", "the", "C0003289#ent", "<e2>", "effects", "of", "adenosine", "in", "human", "atrial", "tissues"], "h": {"id": "C3890193", "name": "C3890193#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [14, 15]}}
{"token": ["C0020538#ent", "<e1>", "pregnancy", "(", "HDP", ":", "C0852036#ent", "<e2>", "preeclampsia", ",", "eclampsia", ")", "affect", "approximately", "10", "%", "of", "human", "births", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0852036", "name": "C0852036#ent", "pos": [6, 7]}}
{"token": ["The", "morphology", "of", "the", "C0015230#ent", "<e1>", "and", "the", "time", "course", "typical", "of", "C0032026#ent", "<e2>"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032026", "name": "C0032026#ent", "pos": [12, 13]}}
{"token": ["The", "incidences", "of", "T", "lymphocytotoxic", "antibodies", "C0015230#ent", "<e1>", "suspected", "of", "viral", "infection", "infectious", "mononucleosis", "rubella", "and", "C0032026#ent", "<e2>", "28", "%", ",", "44", "%", ",", "8", "%", "and", "28", "%", "respectively", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032026", "name": "C0032026#ent", "pos": [16, 17]}}
{"token": ["It", "was", "shown", "that", "C0004962#ent", "<e1>", "and", "arecoline", "evoked", "a", "biphasic", "change", "the", "activity", "of", "the", "C0014442#ent", "<e2>", "and", "the", "electrolyte", "content", "."], "h": {"id": "C0004962", "name": "C0004962#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["However", ",", "optimum", "selectivity", "is", "provided", "by", "a", "combination", "of", "DMI", "and", "C0028277#ent", "<e1>", "in", "animals", "anaesthetized", "with", "a", "combination", "of", "pentobarbitone", "and", "C0700541#ent", "<e2>", "."], "h": {"id": "C0028277", "name": "C0028277#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0700541", "name": "C0700541#ent", "pos": [23, 24]}}
{"token": ["C0037506#ent", "<e1>", "increased", "the", "median", "C3273418#ent", "<e2>", "significantly", "between", "the", "2nd", "and", "10th", "min", "with", "a", "peak", "at", "8", "min", ",", "whereafter", "the", "flow", "decreased", "towards", "baseline", "."], "h": {"id": "C0037506", "name": "C0037506#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273418", "name": "C3273418#ent", "pos": [5, 6]}}
{"token": ["Toward", "understanding", "the", "molecular", "mechanisms", "which", "activated", "C1366449#ent", "<e1>", "is", "internalized", ",", "sorted", "to", "lysosomes", ",", "and", "degraded", ",", "we", "investigated", "whether", "C1366449#ent", "<e1>", "interacted", "with", "sorting", "nexin", "1", "C1420300#ent", "<e1>", ")", "."], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420300", "name": "C1420300#ent", "pos": [29, 30]}}
{"token": ["Since", "BM180", "appears", "to", "be", "required", "for", "stimulus-secretion", "coupling", "by", "lacrimal", "acinar", "cells", "circulating", "anti-alpha-gliadin", "antibodies", "associated", "with", "C0151449#ent", "<e1>", "'", "Dry", "Eye", "'", ")", "and", "more", "commonly", "in", "C0007570#ent", "<e2>", "may", "be", "secretion", "inhibitory", "."], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [29, 30]}}
{"token": ["Cancer-related", "genes", "including", "RAS", "C0034678#ent", "<e1>", "tumor", "suppressor", "genes", "were", "significantly", "dysregulated", "in", "all", "C0277565#ent", "<e2>", "progenitors", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [14, 15]}}
{"token": ["Desquamative", "gingivitis", "a", "clinical", "term", "describe", "red", ",", "painful", ",", "glazed", "and", "friable", "gingivae", "which", "may", "be", "a", "manifestation", "of", "some", "C0006848#ent", "<e1>", "conditions", "such", "as", "C0023646#ent", "<e2>", "the", "vesiculobullous", "disorders"], "h": {"id": "C0006848", "name": "C0006848#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0023646", "name": "C0023646#ent", "pos": [26, 27]}}
{"token": ["Surprisingly", ",", "we", "observed", "that", "reticulocyte", "lysate", "nonspecific", "proteins", ",", "and", "1", "%", "C4048272#ent", "<e1>", "increased", "both", "the", "T3-", "and", "C0812382#ent", "<e2>", "activities", "of", "human", "TR", "beta", "."], "h": {"id": "C4048272", "name": "C4048272#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [20, 21]}}
{"token": ["Fifteen", "patients", "were", "assigned", "to", "the", "treatment", "with", "C0020740#ent", "<e1>", "isobutanolammonium", "and", "15", "to", "the", "treatment", "with", "C0282070#ent", "<e2>"], "h": {"id": "C0020740", "name": "C0020740#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282070", "name": "C0282070#ent", "pos": [17, 18]}}
{"token": ["Consequently", ",", "C0162359#ent", "<e1>", "inhibited", "releases", "of", "cytochrome", "c", "C1826618#ent", "<e2>", "induced", "by", "MPP(+", ")", "."], "h": {"id": "C0162359", "name": "C0162359#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826618", "name": "C1826618#ent", "pos": [9, 10]}}
{"token": ["Four", "immunodominant", "peptides", "harboring", "charged", "amino", "acid", "residues", "with", "topographically", "exposed", "side", "chains", "identified", "by", "sera", "from", "13", "C0026769#ent", "<e1>", "patients", "with", "predetermined", "autoreactivity", "to", "C1420580#ent", "<e2>", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420580", "name": "C1420580#ent", "pos": [25, 26]}}
{"token": ["The", "immunocytochemistry", "and", "immunoprecipitation", "findings", "indicated", "that", "the", "alpha1", "and", "alpha2", "form", "with", "C1420369#ent", "<e1>", "and", "the", "alpha3", "with", "C1417683#ent", "<e2>", "in", "ventricular", "myocytes"], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417683", "name": "C1417683#ent", "pos": [19, 20]}}
{"token": ["C0034063#ent", "<e1>", "induced", "by", "Hypocapnia/alkalosis", "is", "a", "consequence", "of", "C0002063#ent", "<e2>", "and", "not", "of", "hypocapnia", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002063", "name": "C0002063#ent", "pos": [9, 10]}}
{"token": ["Consequently", ",", "we", "tested", "additional", "kinases", "and", "found", "that", "Syk", ",", "but", "not", "C1528376#ent", "<e1>", "or", "Jak2", ",", "is", "a", "potent", "C0031727#ent", "<e2>", "of", "Tarp", "in", "vitro"], "h": {"id": "C1528376", "name": "C1528376#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["Drosophila", "type", "2", "Btk29A", "reveals", "the", "highest", "homology", "to", "C1528376#ent", "<e1>", "among", "mammalian", "C0031727#ent", "<e2>"], "h": {"id": "C1528376", "name": "C1528376#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["The", "role", "of", "C1705979#ent", "<e1>", ",", "CD28", "and", "the", "intracellular", "proteins", "FLICE-inhibitory", "protein", "C1413357#ent", "<e2>", ")", ",", "receptor-interacting", "protein", "RIP", ")", "and", "caspase", "3", "investigated", "."], "h": {"id": "C1705979", "name": "C1705979#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413357", "name": "C1413357#ent", "pos": [13, 14]}}
{"token": ["C0216045#ent", "<e1>", "the", "primary", "product", "the", "C0027126#ent", "<e2>", "may", "be", "located", "at", "the", "intercalated", "discs", "and", "have", "a", "different", "isoform", "in", "cardiac", "tissue"], "h": {"id": "C0216045", "name": "C0216045#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027126", "name": "C0027126#ent", "pos": [6, 7]}}
{"token": ["There", "was", "no", "abnormal", "expansion", "of", "the", "CTG", "triplet", "repeat", "the", "last", "exon", "of", "the", "C0216045#ent", "<e1>", "DMPK", ")", "gene", "associated", "with", "C0027126#ent", "<e2>"], "h": {"id": "C0216045", "name": "C0216045#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027126", "name": "C0027126#ent", "pos": [22, 23]}}
{"token": ["A", "review", "of", "the", "literature", "undoubtedly", "establishes", "C0380447#ent", "<e1>", "as", "a", "viable", "alternative", "for", "the", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C0380447", "name": "C0380447#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [17, 18]}}
{"token": ["Hydrolysis", "of", "each", "of", "these", "peptides", "produces", "a", "different", "steroid", ":", "C1412687#ent", "<e1>", "releases", "17", "alpha-(hydroxymethyl)estra-1,3,5(10),6,8-pentaene-3,17", "beta-diol", "(", "S1", ")", "whereas", "C4086885#ent", "<e2>", "yields", "17", "beta-(hydroxymethyl)estra-1,3,5(10),6,8-pentaene-3,17", "alpha-diol", "(", "S2", ")", "."], "h": {"id": "C1412687", "name": "C1412687#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4086885", "name": "C4086885#ent", "pos": [21, 22]}}
{"token": ["The", "Ca2", "+", "-dependent", "conformational", "change", "required", "for", "C1419786#ent", "<e1>", "to", "bind", "peptide", "sequences", "from", "the", "C-terminal", "portion", "the", "MIIA", "C1424852#ent", "<e2>", "with", "submicromolar", "affinity", "."], "h": {"id": "C1419786", "name": "C1419786#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1424852", "name": "C1424852#ent", "pos": [20, 21]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "determine", "the", "C1705956#ent", "<e1>", "of", "ritonavir", "(RTV)-enhanced", "C0286737#ent", "<e2>", "(", "SQV", ")", "in", "HIV-infected", "pregnant", "women", "an", "area", "under", "the", "curve", "approach", "."], "h": {"id": "C1705956", "name": "C1705956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0286737", "name": "C0286737#ent", "pos": [15, 16]}}
{"token": ["The", "expression", "of", "C1418457#ent", "<e1>", "mRNA", "was", "stimulated", "by", "the", "C0001644#ent", "<e2>", "isoproterenol", ",", "and", "8-(4-chlorophenyl", "thio)adenosine", "3'-5'-cyclic", "monophosphate", "(", "cpt-cAMP", ")", "."], "h": {"id": "C1418457", "name": "C1418457#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [10, 11]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "investigate", "the", "association", "between", "polymorphisms", "of", "the", "hypocretin", "receptor", "2", "gene", "C1415502#ent", "<e1>", ")", "and", "the", "risk", "of", "C0009088#ent", "<e2>", "CH", ")", "."], "h": {"id": "C1415502", "name": "C1415502#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0009088", "name": "C0009088#ent", "pos": [25, 26]}}
{"token": ["The", "DNA", "cleavage", "patterns", "obtained", "with", "XR11576", "were", "different", "from", "those", "induced", "by", "C0594375#ent", "<e1>", "and", "etoposide", ",", "which", "are", "C1458146#ent", "<e2>", "II", "poisons", "respectively", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [13, 14]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "the", "self-administration", "of", "either", "a", "C0304402#ent", "<e1>", "or", "a", "minor", "C0040614#ent", "<e2>", "is", "significantly", "reduced", "when", "it", "is", "associated", "with", "consequent", "loss", "of", "an", "alternative", "reinforcer", ",", "in", "this", "case", "money"], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040614", "name": "C0040614#ent", "pos": [12, 13]}}
{"token": ["Treatment", "of", "RBL", "cells", "with", "the", "C0597217#ent", "<e1>", "pervanadate", "reversed", "the", "inhibitory", "effect", "of", "C1412938#ent", "<e2>", "stimulated", "protein", "tyrosine", "phosphorylation", "indicating", "activation", "of", "phosphatases", "by", "C1412938#ent", "<e2>"], "h": {"id": "C0597217", "name": "C0597217#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412938", "name": "C1412938#ent", "pos": [14, 15]}}
{"token": ["Further", ",", "protein", "tyrosine", "kinase", "lyn", "which", "is", "activated", "by", "the", "antigen", "receptor", "can", "be", "readily", "co-immunoprecipitated", "with", "C1413206#ent", "<e1>", "suggesting", "this", "is", "the", "C0014442#ent", "<e2>", "responsible", "for", "the", "antigen", "receptor", "tyrosine", "phosphorylation", "C1413206#ent", "<e1>", "."], "h": {"id": "C1413206", "name": "C1413206#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [24, 25]}}
{"token": ["The", "binding", "of", "C1332791#ent", "<e1>", "GM-CSF", ")", "to", "its", "receptor", "stimulates", "JAK2", "protein", "kinase", "activation", "protein", "phosphorylation", "and", "C1334291#ent", "<e2>", "association", "with", "the", "beta", "c", "chain", "of", "the", "GM-CSF", "receptor"], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334291", "name": "C1334291#ent", "pos": [18, 19]}}
{"token": ["The", "mechanisms", "of", "these", "C0029896#ent", "<e1>", "are", "not", "known", "but", "C1704665#ent", "<e2>", "induction", "of", "cytokines", "is", "believed", "to", "be", "involved", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [10, 11]}}
{"token": ["In", "the", "course", "of", "studying", "patients", "affected", "with", "arthritic", "diseases", "bronchial", "asthma", "sugar", "diabetes", "a", "relationship", "between", "those", "C0029896#ent", "<e1>", "and", "the", "blood", "groups", "the", "C1704665#ent", "<e2>", "and", "MN", "systems", "was", "established", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [25, 26]}}
{"token": ["Salmonella", "enterica", "serovar", "Typhi", "S.", "typhi", "is", "the", "aetiological", "agent", "C0041466#ent", "<e1>", "a", "serious", "invasive", "C0004623#ent", "<e2>", "humans", "with", "an", "annual", "global", "burden", "approximately", "16", "million", "cases", ",", "leading", "to", "600,000", "fatalities", "."], "h": {"id": "C0041466", "name": "C0041466#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [15, 16]}}
{"token": ["This", "effect", "of", "C0006945#ent", "<e1>", "was", "antagonized", "by", "atropine", "but", "not", "C0041345#ent", "<e2>", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041345", "name": "C0041345#ent", "pos": [11, 12]}}
{"token": ["As", "a", "result", ",", "we", "identified", "Csf4", ",", "a", "C0017976#ent", "<e1>", "an", "apparent", "orthologue", "in", "Saccharomyces", "cerevisiae", "C1540171#ent", "<e2>", ")", ",", "as", "an", "important", "factor", "for", "cell-wall", "integrity", "and", "maintenance", "."], "h": {"id": "C0017976", "name": "C0017976#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1540171", "name": "C1540171#ent", "pos": [17, 18]}}
{"token": ["28.6", "%", "of", "the", "patients", "had", "a", "gradual", "reappearance", "of", "high", "serum", "estradiol", "levels", "and", "of", "C0029927#ent", "<e1>", "and", "were", ",", "therefore", ",", "treated", "with", "second", "course", "of", "C1518041#ent", "<e2>", "."], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1518041", "name": "C1518041#ent", "pos": [28, 29]}}
{"token": ["Thirty-seven", "patients", "who", "had", "C0029927#ent", "<e1>", "categorized", "into", "two", "groups", ":", "group", "A", "n", "=", "14", ")", "with", "baseline", "C0029927#ent", "<e1>", "group", "B", "n", "=", "23", ")", "with", "C0029927#ent", "<e1>", "developed", "during", "pituitary", "suppression", "the", "C1518041#ent", "<e1>"], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1518041", "name": "C1518041#ent", "pos": [35, 36]}}
{"token": ["The", "addition", "of", "C0376261#ent", "<e1>", "Ringer's", "which", "contains", "calcium", "(", "C3539667#ent", "<e2>", ")", "to", "citrated", "blood", "products", "a", "potential", "risk", "whenever", "the", "level", "of", "ionized", "calcium", "reaches", "a", "concentration", "capable", "of", "catalyzing", "the", "coagulation", "cascade"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539667", "name": "C3539667#ent", "pos": [10, 11]}}
{"token": ["Five", "of", "these", "(", "C1334314#ent", "<e1>", "calcreticulin", ",", "heat", "shock", "protein", "27", "serum", "and", "glucocorticoid-regulated", "kinase", "C0215825#ent", "<e2>", ")", "were", "not", "previously", "reported", "to", "be", "expressed", "in", "placenta", "."], "h": {"id": "C1334314", "name": "C1334314#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0215825", "name": "C0215825#ent", "pos": [16, 17]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "evaluate", "if", "the", "sugar", "alcohols", "erythritol", "C0043369#ent", "<e1>", "and", "sorbitol", "enhance", "the", "fungicidal", "effect", "of", "C0079015#ent", "<e2>", "BTC", ")", "toward", "in", "vitro", "candidal", "biofilms", "."], "h": {"id": "C0043369", "name": "C0043369#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0079015", "name": "C0079015#ent", "pos": [22, 23]}}
{"token": ["Besides", ",", "C1434639#ent", "<e1>", "HCC", "was", "positively", "correlated", "with", "protein", "expression", "transcription", "factor", "C1706383#ent", "<e2>", "."], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [13, 14]}}
{"token": ["Serum-stimulated", "C1706383#ent", "<e1>", "expression", "is", "dependent", "on", "C1434639#ent", "<e2>", "the", "MEK", "inhibitor", "PD98059", "suppresses", "Erk", "activity", "C1706383#ent", "<e1>", "expression", "."], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [1, 2]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "overexpression", "of", "C1419227#ent", "<e1>", "in", "PT67", "fibroblasts", "induces", "nuclear", "condensation", "cleavage", "of", "C0291573#ent", "<e2>", "its", "active", "form", "induction", "of", "apoptosis", "."], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [17, 18]}}
{"token": ["Hepatic", "nuclear", "factor-4", "HNF-4", ")", "and", "chicken", "ovalbumin", "upstream-transcription", "factor-II", "in", "the", "C1710463#ent", "<e1>", "the", "PPARalpha", "gene", "while", "C4054191#ent", "<e2>", "PGC-1", ")", "behaves", "as", "a", "PPAR", "coactivator"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4054191", "name": "C4054191#ent", "pos": [18, 19]}}
{"token": ["This", "increase", "was", "abolished", "with", "inhibitors", "of", "C0010536#ent", "<e1>", "C.", "C5b-9", "not", "affect", "low-molecular-mass", "membrane-associated", "or", "secretory", "C0031667#ent", "<e2>", "activities", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "show", "that", "C1424702#ent", "<e1>", "Tfb2", "m", "indeed", "are", "orthologs", "to", "TFB1M", "C1425600#ent", "<e2>"], "h": {"id": "C1424702", "name": "C1424702#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425600", "name": "C1425600#ent", "pos": [13, 14]}}
{"token": ["Aims", "We", "screened", "the", "6q24", "region", ",", "KCNJ11", ",", "GCK", ",", "FOXP3", "and", "C1826562#ent", "<e1>", "mutations", "in", "families", "with", "PNDM", "or", "C1832386#ent", "<e2>", "to", "establish", "a", "phenotype-genotype", "correlation", "."], "h": {"id": "C1826562", "name": "C1826562#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1832386", "name": "C1832386#ent", "pos": [21, 22]}}
{"token": ["Gold", "inhibited", "C0914833#ent", "<e1>", "in", "the", "C0023899#ent", "<e2>", "in", "a", "manner", "typical", "of", "its", "effect", "on", "selenoenzymes", "."], "h": {"id": "C0914833", "name": "C0914833#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}}
{"token": ["It", "may", "be", "concluded", "that", "aberrant", "mitogenic", "signaling", "in", "human", "breast", "cancer", "in", "vivo", "Pak", ",", "p38", "MAPK", "C0248446#ent", "<e1>", "downstream", "of", "C2713509#ent", "<e2>", ",", "but", "neither", "of", "PKB", "or", "p70", "S6K"], "h": {"id": "C0248446", "name": "C0248446#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "both", "C0812242#ent", "<e1>", "and", "Cbl-b", "can", "initiate", "a", "phosphatidylinositol", "3-kinase/protein", "kinase", "B-independent", "signaling", "pathway", "to", "C4082284#ent", "<e2>", "GLUT4", "translocation", "."], "h": {"id": "C0812242", "name": "C0812242#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [17, 18]}}
{"token": ["However", ",", "it", "frequently", "differs", "by", "early", "development", "arthritis", "after", "C0001344#ent", "<e1>", ",", "more", "prolonged", "arthritis", "or", "C0019559#ent", "<e2>", "and", "a", "less", "dramatic", "response", "to", "aspirin", "."], "h": {"id": "C0001344", "name": "C0001344#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019559", "name": "C0019559#ent", "pos": [17, 18]}}
{"token": ["The", "yield", "of", "N-", "and", "C-terminal", "amino", "acids", "the", "number", "of", "C0030956#ent", "<e1>", "tryptophan", "sequences", "the", "above", "polyacrylamide-gel", "electrophoretic", "measurement", "suggest", "that", "C0041945#ent", "<e2>", "contains", "a", "single", "structural", "subunit", "molecular", "weight", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041945", "name": "C0041945#ent", "pos": [22, 23]}}
{"token": ["By", "acting", "on", "phosphorylation", "of", "C1704984#ent", "<e1>", "and", "PI-3", "kinase", "TNF-alpha", "promotes", "significantly", "insulin", "resistance", "causes", "deterioration", "of", "C0011849#ent", "<e2>", ",", "as", "well", "as", "elevated", "body", "temperature", "sleepiness", "and", "anorexia", "."], "h": {"id": "C1704984", "name": "C1704984#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [18, 19]}}
{"token": ["An", "inhibitor", "of", "p38", "phosphorylation", "C0291985#ent", "<e1>", ")", "completely", "prevented", "C1417048#ent", "<e2>", "formation", "."], "h": {"id": "C0291985", "name": "C0291985#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [10, 11]}}
{"token": ["UBP43", "belongs", "to", "the", "family", "of", "C1447339#ent", "<e1>", "specifically", "cleaves", "ISG15", ",", "a", "C1539895#ent", "<e2>", "is", "induced", "by", "cellular", "stresses", "such", "as", "type", "1", "interferons", "IFN", ")", ",", "nephrotoxic", "damage", "and", "bacterial", "infection"], "h": {"id": "C1447339", "name": "C1447339#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539895", "name": "C1539895#ent", "pos": [13, 14]}}
{"token": ["The", "severity", "and", "frequency", "of", "barium", "flocculation", "glycogen", "deposition", "aggregation", "of", "C1826396#ent", "<e1>", "and", "lamellar", "inclusion", "bodies", "axons", "were", "directly", "related", "to", "duration", "of", "C0162275#ent", "<e2>", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162275", "name": "C0162275#ent", "pos": [24, 25]}}
{"token": ["Special", "studies", "required", "to", "describe", "the", "association", "of", "nutrition-related", "factors", "with", "C0008679#ent", "<e1>", "particularly", "those", "prevalent", "in", "C0994408#ent", "<e2>"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0994408", "name": "C0994408#ent", "pos": [17, 18]}}
{"token": ["Both", "C0546860#ent", "<e1>", "%", "and", "brimonidine", "tartrate", "%", "are", "potent", "C2746076#ent", "<e2>", "effective", "in", "controlling", "the", "intraocular", "pressure", "IOP", ")", "rise", "following", "argon", "laser", "trabeculoplasty", "ALT", ")", "."], "h": {"id": "C0546860", "name": "C0546860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2746076", "name": "C2746076#ent", "pos": [10, 11]}}
{"token": ["These", "results", "indicate", "that", "C3853652#ent", "<e1>", ",", "or", "another", "C0038085#ent", "<e2>", "is", "essential", "for", "the", "consecutive", "phosphorylation", "of", "the", "N-", "and", "C-terminal", "ITIM"], "h": {"id": "C3853652", "name": "C3853652#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [9, 10]}}
{"token": ["The", "lymphocyte-specific", "kinase", "C3853652#ent", "<e1>", ")", ",", "a", "member", "of", "the", "C0038085#ent", "<e2>", "cytoplasmic", "tyrosine", "kinases", "is", "expressed", "in", "T", "cells", "natural", "killer", "NK", ")", "cells", "."], "h": {"id": "C3853652", "name": "C3853652#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [11, 12]}}
{"token": ["The", "lymphocyte-specific", "kinase", "C3853652#ent", "<e1>", ")", "is", "a", "cytoplasmic", "tyrosine", "kinase", "the", "C0038085#ent", "<e2>", "expressed", "in", "T", "cells", "natural", "killer", "NK", ")", "cells", "."], "h": {"id": "C3853652", "name": "C3853652#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [12, 13]}}
{"token": ["The", "ability", "of", "C0022575#ent", "<e1>", "to", "express", "mouse", "interleukin", "1", "C1522428#ent", "<e2>", ")", "showed", "a", "significant", "decline", "at", "2", "h", "following", "hemorrhage", ",", "but", "this", "effect", "was", "not", "apparent", "at", "24", "h", "post-hemorrhage", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [10, 11]}}
{"token": ["The", "intron", "content", "of", "the", "primary", "transcript", "not", "influence", "the", "rate", "of", "C0022575#ent", "<e1>", "mRNA", "translation", "and", "did", "not", "modulate", "the", "ability", "of", "C1522428#ent", "<e2>", "stimulation", "to", "stabilize", "the", "otherwise", "unstable", "mRNA", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [23, 24]}}
{"token": ["We", "report", "on", "four", "patients", "with", "a", "histologically", "proven", "diagnosis", "of", "C1956391#ent", "<e1>", "clinical", "and/or", "neuroradiological", "evidence", "of", "severe", "focal", "cerebral", "ischemia", "to", "C0751895#ent", "<e2>"], "h": {"id": "C1956391", "name": "C1956391#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0751895", "name": "C0751895#ent", "pos": [23, 24]}}
{"token": ["In", "order", "to", "investigate", "the", "downstream", "targets", "of", "C1413947#ent", "<e1>", ",", "and", "the", "transforming", "effects", "of", "the", "C1852061#ent", "<e2>", "we", "have", "introduced", "DDIT3-GFP", "and", "FUS-DDIT3-GFP", "constructs", "into", "a", "human", "fibrosarcoma", "cell", "line"], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [8, 9]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1852061", "name": "C1852061#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "depletion", "of", "C1705002#ent", "<e1>", "and", "TIN2", "or", "C1420448#ent", "<e2>", "abrogates", "the", "requirement", "for", "tankyrase", "1", "mitotic", "progression"], "h": {"id": "C1705002", "name": "C1705002#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420448", "name": "C1420448#ent", "pos": [9, 10]}}
{"token": ["In", "the", "C2673193#ent", "<e1>", "mutations", "affecting", "the", "C1412114#ent", "<e2>", "been", "so", "far", "identified", "."], "h": {"id": "C2673193", "name": "C2673193#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412114", "name": "C1412114#ent", "pos": [7, 8]}}
{"token": ["Unstimulated", "C0036202#ent", "<e1>", "and", "normal", "AMs", "produced", "little", "TNF", ",", "but", "C0175697#ent", "<e2>", "stimulation", "enhanced", "TNF", "production", "by", "both", "normal", "and", "C0036202#ent", "<e1>", "AMs", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0036202", "name": "C0036202#ent", "pos": [1, 2]}}
{"token": ["C0053355#ent", "<e1>", "therefore", "increases", "both", "C0879590#ent", "<e2>", "sensitivity", "and", "C0879590#ent", "<e2>", "production", "."], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [5, 6]}}
{"token": ["Conversely", ",", "C0162508#ent", "<e1>", "ubiquitination", "is", "increased", "by", "adding", "purified", "C1708805#ent", "<e2>", "or", "extracts", "prepared", "from", "cells", "transfected", "with", "C1708805#ent", "<e2>", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1708805", "name": "C1708805#ent", "pos": [10, 11]}}
{"token": ["A", "series", "of", "imidazo[1,2-a]pyrimidine-", ",", "imidazo[1,2-c]pyrimidine-", "and", "imidazo[1,2-b]pyridazinecarboxamides", "and", "C0050423#ent", "<e1>", "were", "prepared", "and", "their", "antiinflammatory", ",", "analgesic", ",", "C0003419#ent", "<e2>", "and", "ulcerogenic", "activities", "were", "evaluated", "."], "h": {"id": "C0050423", "name": "C0050423#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [19, 20]}}
{"token": ["The", "inhibition", "of", "PLA2", "activity", "did", "not", "prevent", "the", "phosphorylation", "of", "p47", ",", "suggesting", "that", "the", "location", "of", "C1418617#ent", "<e1>", "is", "downstream", "of", "and", "does", "not", "activate", "C0010536#ent", "<e2>"], "h": {"id": "C1418617", "name": "C1418617#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [27, 28]}}
{"token": ["C0064774#ent", "<e1>", "and", "bromocriptine", "at", "higher", "concentrations", "inhibit", "C1420718#ent", "<e2>", ",", "and", "reverse", "the", "apomorphine", "elicited", "enzyme", "inhibition", "."], "h": {"id": "C0064774", "name": "C0064774#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [8, 9]}}
{"token": ["Glutathione", "is", "C0025517#ent", "<e1>", "in", "the", "C0033993#ent", "<e2>", "which", "involves", "six", "different", "enzymes", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [6, 7]}}
{"token": ["This", "last", "compound", "is", "C0025517#ent", "<e1>", "to", "leukotrienes", "D4", "E4", "by", "successive", "elimination", "of", "a", "C0033993#ent", "<e2>", "glycine", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [15, 16]}}
{"token": ["Complications", "occurred", "less", "often", "during", "C1540026#ent", "<e1>", "than", "during", "stress-ECG", "(", "C0002962#ent", "<e2>", "4", "%", "and", "25", "%", ",", "ventricular", "extrasystoles", "%", "and", "16", "%", ",", "respectively", ")", "."], "h": {"id": "C1540026", "name": "C1540026#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [11, 12]}}
{"token": ["We", "further", "show", "that", "promoters", "containing", "Pbx1-binding", "sites", "are", "activated", "by", "the", "chimeric", "C0289575#ent", "<e1>", "not", "by", "C1418285#ent", "<e2>", "."], "h": {"id": "C0289575", "name": "C0289575#ent", "pos": [13, 14]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1418285", "name": "C1418285#ent", "pos": [17, 18]}}
{"token": ["The", "leukemogenic", "transcription", "factor", "gene", "C0289575#ent", "<e1>", "is", "created", "through", "fusion", "of", "the", "genes", "E2A", "and", "C1418285#ent", "<e2>", "as", "a", "result", "of", "t(1;19)", "acute", "lymphoblastic", "leukemia"], "h": {"id": "C0289575", "name": "C0289575#ent", "pos": [5, 6]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1418285", "name": "C1418285#ent", "pos": [16, 17]}}
{"token": ["Genetic", "analysis", "C1705526#ent", "<e1>", "as", "a", "mediator", "of", "the", "renal", "dysplasia", "salt-stressed", "C1332407#ent", "<e2>", "acting", "partly", "via", "repression", "of", "terminal", "epithelial", "differentiation", "genes", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332407", "name": "C1332407#ent", "pos": [12, 13]}}
{"token": ["We", "found", "that", "C1417099#ent", "<e1>", ",", "but", "not", "MEF2B", "or", "C1417103#ent", "<e2>", ",", "is", "a", "substrate", "for", "p38", "."], "h": {"id": "C1417099", "name": "C1417099#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417103", "name": "C1417103#ent", "pos": [10, 11]}}
{"token": ["The", "sites", "phosphorylated", "by", "activated", "BMK1", "were", "mapped", "to", "Ser-355", ",", "Thr-312", ",", "and", "Thr-319", "of", "C1417099#ent", "<e1>", "and", "Ser-179", "of", "C1417103#ent", "<e2>", "both", "in", "vitro", "in", "vivo"], "h": {"id": "C1417099", "name": "C1417099#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417103", "name": "C1417103#ent", "pos": [21, 22]}}
{"token": ["While", "the", "molecular", "mechanism", "C1704657#ent", "<e1>", "regulation", "of", "C0919336#ent", "<e2>", "secretion", "in", "tumor", "cells", "unclear", ",", "our", "results", "suggested", "that", "blockade", "of", "the", "EGFR-signaling", "pathway", "contributed", "to", "the", "net", "effect"], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [8, 9]}}
{"token": ["While", "individual", "differences", "could", "be", "detected", ",", "there", "was", "no", "overall", "correlation", "between", "Bcl-2", "and", "the", "expression", "and", "activity", "of", "superoxide", "dismutases", "C0007367#ent", "<e1>", ",", "glutathione", "peroxidases", "thioredoxin", ",", "thioredoxin", "reductases", "and", "C1136747#ent", "<e2>", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1136747", "name": "C1136747#ent", "pos": [32, 33]}}
{"token": ["Lengths", "were", "greater", "in", "C0004096#ent", "<e1>", "lowest", "in", "those", "with", "high", "C3537453#ent", "<e2>", "usage", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537453", "name": "C3537453#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "aimed", "to", "investigate", "the", "genetic", "association", "C2346907#ent", "<e1>", "codon-54", "polymorphism", "in", "patients", "with", "C0026691#ent", "<e2>", ",", "and", "to", "investigate", "possible", "associations", "with", "clinical", "manifestations", "the", "disease", "."], "h": {"id": "C2346907", "name": "C2346907#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [16, 17]}}
{"token": ["Epithelioid", "and", "giant", "cells", "sarcoidosis", ",", "C0041296#ent", "<e1>", ",", "granulomatous", "hepatitis", "and", "tuberculoid", "leprosy", "showed", "the", "presence", "of", "C0026794#ent", "<e2>", "in", "their", "cytoplasm", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026794", "name": "C0026794#ent", "pos": [18, 19]}}
{"token": ["Seven", "patients", "aged", "13", "to", "17.5", "years", "developed", "acute", "renal", "failure", "treatment", "with", "a", "variety", "of", "non-steroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", ":", "naproxen", ",", "diclofenac", ",", "C0020740#ent", "<e2>", ",", "dipyrone", "and", "paracetamol", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [19, 20]}, "relation": "structural_class_of", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [27, 28]}}
{"token": ["Uptake", "in", "normal", "and", "magnesium-depleted", "cells", "was", "inhibited", "by", "the", "channel", "antagonist", "C0280858#ent", "<e1>", ",", "and", "increased", "with", "the", "C2987634#ent", "<e2>", ",", "Bay", "K", "8644"], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [19, 20]}}
{"token": ["The", "systemic", "and", "pulmonary", "arterial", "hemodynamics", "40", "patients", "with", "severe", "C0018802#ent", "<e1>", "determined", "during", "a", "24-hour", "infusion", "of", "C0128513#ent", "<e2>", "(", "0.5", "micrograms/kg/min", ")", "after", "a", "loading", "dose", "50", "micrograms/kg", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0128513", "name": "C0128513#ent", "pos": [18, 19]}}
{"token": ["C3540579#ent", "<e1>", "clones", "showed", "significantly", "higher", "migration", "to", "RA", "ST", "C1537486#ent", "<e2>", "with", "Th2", "clones", "."], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537486", "name": "C1537486#ent", "pos": [10, 11]}}
{"token": ["Lysine-rich", "and", "C1332114#ent", "<e1>", "examined", "as", "substrates", "for", "C0024341#ent", "<e2>"], "h": {"id": "C1332114", "name": "C1332114#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024341", "name": "C0024341#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "describe", "the", "successful", "use", "of", "intravenous", "immunoglobulin", "IVIG", ")", "in", "the", "management", "of", "mycoplasma-induced", ",", "atypical", "C0038325#ent", "<e1>", "SJS", ")", "with", "minimal", "C0037274#ent", "<e2>"], "h": {"id": "C0038325", "name": "C0038325#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [24, 25]}}
{"token": ["The", "overall", "absorption", "of", "C0065374#ent", "<e1>", "may", "be", "reduced", "in", "some", "C0018802#ent", "<e2>", "patients", ";", "consequently", ",", "the", "onset", "of", "effect", "is", "delayed", "but", "is", "often", "more", "prolonged", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}}
{"token": ["Chronic", "RAAS-blockade", "with", "C0065374#ent", "<e1>", "and", "candesartan", "cilexetil", "normalised", "endothelial", "function", "C0018802#ent", "<e2>", "in", "a", "comparable", "way", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}}
{"token": ["A", "cost-effectiveness", "analysis", "high", "and", "low", "doses", "of", "the", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitor", "C0065374#ent", "<e1>", "in", "the", "treatment", "of", "C0018802#ent", "<e2>"], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["In", "the", "Western", "blots", "arachnoid", "villi", "meningiomas", ",", "C4283800#ent", "<e1>", "and", "Cx43", "were", "shown", "at", "bands", "with", "molecular", "weights", "26", "C1839259#ent", "<e2>", "and", "42", "-", "47", "C1839259#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C4283800", "name": "C4283800#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [20, 21]}}
{"token": ["The", "expression", "level", "of", "C1415467#ent", "<e1>", "was", "also", "elevated", "during", "C1423721#ent", "<e2>", "three", "of", "the", "four", "strains", "."], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423721", "name": "C1423721#ent", "pos": [10, 11]}}
{"token": ["C1706342#ent", "<e1>", "encodes", "a", "C3275243#ent", "<e2>", "344", "aa", "and", "of", "Mr", "36,275", "."], "h": {"id": "C1706342", "name": "C1706342#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3275243", "name": "C3275243#ent", "pos": [4, 5]}}
{"token": ["The", "surface", "markers", "CD30", ",", "CD74", ",", "and", "C1419891#ent", "<e1>", "were", "down-regulated", "in", "C0149678#ent", "<e2>", "convertants", "."], "h": {"id": "C1419891", "name": "C1419891#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [13, 14]}}
{"token": ["The", "alkyl", "side", "chains", "the", "wax", "C1539788#ent", "<e1>", "contained", "odd", "numbers", "of", "C0524928#ent", "<e2>", "ranging", "from", "C19", "to", "C27", ",", "with", "a", "prevalence", "of", "C21", ",", "C23", "and", "C25", "."], "h": {"id": "C1539788", "name": "C1539788#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [12, 13]}}
{"token": ["In", "the", "class", "of", "topical", "NSAIDs", ",", "ketorolac", "has", "been", "promoted", "for", "ocular", "itching", "has", "been", "found", "to", "be", "inferior", "for", "relief", "of", "C0009766#ent", "<e1>", "compared", "with", "olopatadine", "and", "C0064263#ent", "<e2>", "."], "h": {"id": "C0009766", "name": "C0009766#ent", "pos": [23, 24]}, "relation": "may_be_treated_by", "t": {"id": "C0064263", "name": "C0064263#ent", "pos": [29, 30]}}
{"token": ["In", "addition", "to", "phosphofructokinase", ",", "the", "following", "enzymes", "have", "been", "stepwise", "included", "into", "the", "reaction", "systems", "composing", "the", "Models", "1", "through", "6", ":", "pyruvate", "kinase", "C1412305#ent", "<e1>", "hexokinase", ",", "and", "C0017759#ent", "<e2>"], "h": {"id": "C1412305", "name": "C1412305#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0017759", "name": "C0017759#ent", "pos": [30, 31]}}
{"token": ["In", "CEL/HES", "the", "detection", "of", "the", "C3274897#ent", "<e1>", "fusion", "gene", "overexpression", "of", "C1335201#ent", "<e2>", "and", "PDGFRB", "led", "to", "targeted", "therapy", "tyrosine", "kinase", "inhibitors"], "h": {"id": "C3274897", "name": "C3274897#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335201", "name": "C1335201#ent", "pos": [12, 13]}}
{"token": ["Immunoblot", "analysis", "that", "C3811250#ent", "<e1>", "is", "localized", "almost", "exclusively", "in", "mitochondria", ",", "whereas", "C3811249#ent", "<e2>", "is", "a", "cytosolic", "protein"], "h": {"id": "C3811250", "name": "C3811250#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811249", "name": "C3811249#ent", "pos": [13, 14]}}
{"token": ["Immunoprecipitation", "studies", "that", "neither", "collagen", "alone", "nor", "the", "combination", "of", "collagen", "plus", "C0917834#ent", "<e1>", "induced", "phosphorylation", "of", "the", "GPVI-regulated", "proteins", "C1335892#ent", "<e2>", "and", "SLP-76", "(", "Src", "homology", "2-containing", "leucocyte", "protein", "76", "kDa", ")", "."], "h": {"id": "C0917834", "name": "C0917834#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [20, 21]}}
{"token": ["As", "indicated", "by", "Raf", "protein", "kinase", "assays", "C1423842#ent", "<e1>", "inhibits", "A-Raf", "kinase", "whereas", "neither", "B-Raf", "nor", "C0139905#ent", "<e2>", "kinase", "activity", "influenced", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [16, 17]}}
{"token": ["The", "opportunistic", "human", "pathogen", "Candida", "albicans", "known", "to", "express", "CuZnSOD", "(", "SOD1", ")", "and", "MnSOD", "(", "C1420308#ent", "<e1>", ")", "in", "the", "cytosol", "and", "MnSOD", "(", "C1420307#ent", "<e2>", ")", "in", "the", "mitochondria", "."], "h": {"id": "C1420308", "name": "C1420308#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420307", "name": "C1420307#ent", "pos": [25, 26]}}
{"token": ["To", "investigate", "the", "role", "of", "the", "shared", "epitope", "in", "determining", "susceptibility", "to", "and", "the", "phenotype", "of", "C1168305#ent", "<e1>", "patients", "with", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C1168305", "name": "C1168305#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "there", "was", "a", "different", "effect", "of", "three", "hydroxamic", "acid-based", "inhibitors", "(", "batimastat", ",", "compound", "1", "compound", "4", "towards", "C1706637#ent", "<e1>", "compared", "to", "ACE", "C0699919#ent", "<e2>", "and", "alpha-secretase", "."], "h": {"id": "C1706637", "name": "C1706637#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [26, 27]}}
{"token": ["Apparently", "normal", "levels", "of", "mRNA", "were", "generated", "from", "this", "C0002085#ent", "<e1>", ",", "but", "no", "C3853627#ent", "<e2>", "activity", "or", "immuno-cross-reactive", "material", "could", "be", "detected", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3853627", "name": "C3853627#ent", "pos": [14, 15]}}
{"token": ["C1332794#ent", "<e1>", "a", "therapeutic", "target", "for", "C0012634#ent", "<e2>", "has", "been", "validated", "by", "gene", "knockout", "studies", "."], "h": {"id": "C1332794", "name": "C1332794#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [6, 7]}}
{"token": ["3-phosphoinositide-dependent", "kinase-1", "PDK1", ")", "phosphorylates", "and", "activates", "several", "C0031727#ent", "<e1>", "in", "the", "cAMP-dependent", ",", "C3489929#ent", "<e2>", "and", "protein", "kinase", "C", "AGC", ")", "family", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3489929", "name": "C3489929#ent", "pos": [14, 15]}}
{"token": ["Excess", "production", "and", "bioactivation", "of", "C1515406#ent", "<e1>", "at", "sites", "of", "C1826313#ent", "<e2>", "infection", "may", "undermine", "host", "immune", "responses", "TB", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826313", "name": "C1826313#ent", "pos": [10, 11]}}
{"token": ["The", "response", "to", "C0015827#ent", "<e1>", "(", "1", "mg/kg", ")", "was", "antagonized", "by", "C0036442#ent", "<e2>", "(", "0.032", "-", "1", "mg/kg", ")", "but", "not", "by", "methyl-scopolamine", "(", "0.032", "-", "1", "mg/kg", ")", "pre-treatment", "."], "h": {"id": "C0015827", "name": "C0015827#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [12, 13]}}
{"token": ["Eosinophilic", "C0878544#ent", "<e1>", "a", "complication", "of", "the", "C1540912#ent", "<e2>", "of", "several", "other", "disorders", "associated", "with", "high", "blood", "eosinophil", "counts", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1540912", "name": "C1540912#ent", "pos": [7, 8]}}
{"token": ["Heart", "disease", "patients", "with", "progressive", "C1290138#ent", "<e1>", "be", "due", "in", "part", "to", "C0151744#ent", "<e2>", "by", "a", "disturbance", "of", "the", "coronary", "microcirculation"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [12, 13]}}
{"token": ["We", "studied", "nine", "autopsied", "patients", "with", "progressive", "C1290138#ent", "<e1>", "evidence", "of", "C0151744#ent", "<e2>", "morphologically", "normal", "coronary", "arteries"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [11, 12]}}
{"token": ["Left", "ventricular", "dysfunction", "C1290138#ent", "<e1>", "be", "due", "in", "part", "to", "C0151744#ent", "<e2>", "by", "a", "disturbance", "in", "coronary", "microcirculation"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [10, 11]}}
{"token": ["C4053955#ent", "<e1>", "DPLN", ")", "is", "the", "most", "severe", "form", "in", "C0024143#ent", "<e2>"], "h": {"id": "C4053955", "name": "C4053955#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [10, 11]}}
{"token": ["Inhaled", "nitric", "oxide", "NO", ")", "is", "a", "rapidly", "acting", "selective", "C0042402#ent", "<e1>", "partially", "reverses", "the", "pathophysiology", "of", "acute", "respiratory", "distress", "syndrome", "C0243025#ent", "<e2>", ")", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0243025", "name": "C0243025#ent", "pos": [21, 22]}}
{"token": ["The", "present", "study", "evaluated", "the", "C0242912#ent", "<e1>", "and", "anticonvulsant", "effects", "EGIS-8332", ",", "a", "C3555655#ent", "<e2>", "as", "a", "potential", "drug", "candidate", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3555655", "name": "C3555655#ent", "pos": [13, 14]}}
{"token": ["The", "apparent", "relative", "low", "catalytic", "activity", "jumbo", "squid", "muscle", "C1412387#ent", "<e1>", "the", "absence", "of", "positive", "effectors", "similar", "to", "that", "reported", "for", "C1512488#ent", "<e2>", "enzymes", "in", "other", "invertebrate", "organisms"], "h": {"id": "C1412387", "name": "C1412387#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [21, 22]}}
{"token": ["One", "C0085582#ent", "<e1>", "patient", "has", "a", "family", "history", "C1417325#ent", "<e2>", "but", "has", "no", "neurologic", "abnormalities"], "h": {"id": "C0085582", "name": "C0085582#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [8, 9]}}
{"token": ["Compared", "to", "the", "known", "peroxynitrite", "scavenger", "C0058903#ent", "<e1>", ",", "the", "most", "active", "C1257966#ent", "<e2>", "proved", "to", "be", "10", "times", "more", "effective", "."], "h": {"id": "C0058903", "name": "C0058903#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1257966", "name": "C1257966#ent", "pos": [12, 13]}}
{"token": ["These", "observations", "are", "consistent", "with", "notion", "that", "the", "mutD", "gene", "product", "is", "a", "subunit", "of", "C0012890#ent", "<e1>", "and", "it", "either", "contains", "the", "catalytic", "site", "the", "C0950448#ent", "<e2>", "or", "modulates", "its", "activity", "."], "h": {"id": "C0012890", "name": "C0012890#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0950448", "name": "C0950448#ent", "pos": [25, 26]}}
{"token": ["To", "66", "consecutive", "patients", "with", "Cushing's", "syndrome", "70", "with", "C0018213#ent", "<e1>", "after", "treatment", ",", "a", "semistructured", "interview", "for", "C0086132#ent", "<e2>", "on", "Paykel", "'s", "clinical", "interview", "depression", "was", "administered", "."], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086132", "name": "C0086132#ent", "pos": [18, 19]}}
{"token": ["The", "presence", "of", "two", "chromodomains", "in", "KIS-L", "suggested", "that", "its", "recruitment", "or", "function", "might", "be", "regulated", "by", "the", "methylation", "of", "C3829684#ent", "<e1>", "the", "trithorax", "group", "proteins", "C1332009#ent", "<e2>", "and", "TRX", "."], "h": {"id": "C3829684", "name": "C3829684#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1332009", "name": "C1332009#ent", "pos": [26, 27]}}
{"token": ["In", "addition", ",", "a", "marked", "increase", "of", "C1539478#ent", "<e1>", "mRNA", "and", "C1706006#ent", "<e2>", "expression", "was", "observed", "in", "DC-stimulated", "NK", "cells"], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [11, 12]}}
{"token": ["The", "biological", "activity", "CpG", "oligodeoxynucleotide", "2216", "ODN2216", ")", ",", "a", "Toll-like", "receptor", "9", "C2987634#ent", "<e1>", ",", "was", "investigated", "with", "monocytes", "from", "C3854222#ent", "<e2>", "and", "HIV-positive", "(", "HIV+", ")", "donors", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [21, 22]}}
{"token": ["The", "trnL(CAA", ")", "gene", "sequence", "about", "99", "%", "in", "similarity", "to", "broad", "C2677573#ent", "<e1>", ",", "cauliflower", ",", "maize", ",", "spinach", "and", "tobacco", "corresponding", "C1417679#ent", "<e2>", "."], "h": {"id": "C2677573", "name": "C2677573#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [23, 24]}}
{"token": ["C1417012#ent", "<e1>", "LZK", ")", "is", "a", "new", "member", "of", "the", "C1431040#ent", "<e2>"], "h": {"id": "C1417012", "name": "C1417012#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1431040", "name": "C1431040#ent", "pos": [10, 11]}}
{"token": ["Phosphorylation", "experiments", "suggest", "that", "one", "or", "several", "C0031727#ent", "<e1>", "are", "able", "to", "interact", "with", "the", "SH2", "from", "C3853652#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3853652", "name": "C3853652#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "in", "B", "cells", "AgR", "cross-linking", "activates", "C3853652#ent", "<e1>", "and", "subsequently", "activates", "a", "C0031727#ent", "<e2>", "that", "phosphorylates", "C3853652#ent", "<e1>", "at", "serine", "59", ",", "a", "potential", "negative", "regulatory", "site"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3853652", "name": "C3853652#ent", "pos": [8, 9]}}
{"token": ["While", "studies", "in", "animal", "models", "neuropathic", "pain", "clinical", "observations", "to", "a", "role", "of", "the", "sympathetic", "nervous", "system", "certain", "C0150055#ent", "<e1>", "the", "function", "of", "the", "C0039051#ent", "<e2>", "in", "postoperative", "pain", "inflammation", "is", "debatable", "."], "h": {"id": "C0150055", "name": "C0150055#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0039051", "name": "C0039051#ent", "pos": [24, 25]}}
{"token": ["In", "contrast", ",", "expression", "of", "C0919457#ent", "<e1>", "did", "not", "modulate", "sensitivity", "to", "C0678133#ent", "<e2>", ",", "but", "produced", "a", "slight", "increase", "in", "sensitivity", "to", "cisplatin", ",", "as", "shown", "by", "colony-forming", "assays"], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0678133", "name": "C0678133#ent", "pos": [12, 13]}}
{"token": ["On", "similar", "treatment", "in", "the", "presence", "of", "C0037556#ent", "<e1>", "revealed", "four", "C0072522#ent", "<e2>", "zones", "with", "apparent", "Mr", "of", "15,200", ",", "18,300", ",", "23,500", "and", "25,300", "."], "h": {"id": "C0037556", "name": "C0037556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [11, 12]}}
{"token": ["C0037556#ent", "<e1>", "gel", "electrophoresis", "that", "five", "major", "C0072522#ent", "<e2>", "labelled", "with", "[3H]glucosamine", "also", "were", "labelled", "with", "35SO4", "."], "h": {"id": "C0037556", "name": "C0037556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}}
{"token": ["The", "article", "summarizes", "the", "fascinating", "story", "of", "this", "herbal", "medicine", "its", "way", "to", "Europe", ",", "identification", "of", "the", "C1456557#ent", "<e1>", "and", "provides", "background", "information", "of", "the", "many", "profound", "C0003204#ent", "<e2>", "clinical", "studies"], "h": {"id": "C1456557", "name": "C1456557#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003204", "name": "C0003204#ent", "pos": [28, 29]}}
{"token": ["All", "analogs", "were", "single", "amino", "acid", "modifications", "of", "C0525856#ent", "<e1>", "and", "employed", "C2917660#ent", "<e2>", "substitutions", "of", "known", "effects", "in", "linear", "enkephalin", "analogs"], "h": {"id": "C0525856", "name": "C0525856#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [12, 13]}}
{"token": ["People", "with", "C0011849#ent", "<e1>", "do", "not", "regularly", "utilise", "eye", "services", "the", "early", "prevention", "vision", "loss", "to", "C0342245#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0342245", "name": "C0342245#ent", "pos": [16, 17]}}
{"token": ["At", "concentrations", "found", "in", "the", "rectal", "lumen", "the", "C0036077#ent", "<e1>", "used", "in", "C0010346#ent", "<e2>", "impair", "the", "binding", "of", "IFN", "gamma", "its", "receptor", "on", "colonic", "epithelial", "cells"], "h": {"id": "C0036077", "name": "C0036077#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [12, 13]}}
{"token": ["BCR", "ligation", "induced", "rapid", "tyrosine-phosphorylation", "of", "C1417018#ent", "<e1>", "mainly", "by", "C1335892#ent", "<e2>", "and", "Lyn", ",", "resulting", "in", "its", "association", "with", "BASH", "and", "catalytic", "activation"], "h": {"id": "C1417018", "name": "C1417018#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [10, 11]}}
{"token": ["This", "is", "true", "for", "almost", "all", "episodes", "of", "bronchitis", "and", "C0006274#ent", "<e1>", "but", "also", "for", "the", "majority", "of", "C3714636#ent", "<e2>", "."], "h": {"id": "C0006274", "name": "C0006274#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [18, 19]}}
{"token": ["Gelatinase", "A", "C0255672#ent", "<e1>", "gelatinase", "B", "be", "activated", "by", "C0256102#ent", "<e2>", "based", "mechanisms", ",", "as", "evidenced", "by", "both", "biochemical", "and", "cell", "based", "studies", "."], "h": {"id": "C0255672", "name": "C0255672#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0256102", "name": "C0256102#ent", "pos": [9, 10]}}
{"token": ["They", "were", "namely", "those", "of", "stromelysin", "1", "stromelysin", "3", "C0255672#ent", "<e1>", "gelatinase", "A", "GelA", ")", ",", "gelatinase", "B", "and", "C0256102#ent", "<e2>", "MT1-MMP", ")", "."], "h": {"id": "C0255672", "name": "C0255672#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0256102", "name": "C0256102#ent", "pos": [19, 20]}}
{"token": ["We", "examined", "the", "role", "of", "HGF", ",", "C0215993#ent", "<e1>", ",", "and", "c-Met", "in", "synovial", "tissues", "C0003873#ent", "<e2>", "RA", ")", "and", "osteoarthritis", "(", "OA", ")", ",", "and", "their", "localization", "and", "mRNA", "expression", "."], "h": {"id": "C0215993", "name": "C0215993#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}}
{"token": ["We", "examined", "the", "role", "of", "HGF", ",", "C0215993#ent", "<e1>", ",", "and", "c-Met", "in", "synovial", "tissues", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "and", "osteoarthritis", "(", "OA", ")", ",", "and", "their", "localization", "and", "mRNA", "expression", "."], "h": {"id": "C0215993", "name": "C0215993#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "polyamines", "on", "rat-liver", "isoelucyl-tRNA", "formation", "was", "studied", "using", "C0022194#ent", "<e1>", "by", "column", "chromatography", "on", "Sephadex", "G-200", "C0057214#ent", "<e2>", "and", "tRNA-Sepharose", "4B", "."], "h": {"id": "C0022194", "name": "C0022194#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0057214", "name": "C0057214#ent", "pos": [19, 20]}}
{"token": ["The", "pathogenesis", "of", "C3811244#ent", "<e1>", "may", "involve", "both", "immune", "and", "C0455988#ent", "<e2>", "mechanisms", "."], "h": {"id": "C3811244", "name": "C3811244#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [10, 11]}}
{"token": ["The", "C0035678#ent", "<e1>", "HIV-1", "encoding", "the", "protease", ",", "C0035379#ent", "<e2>", "RT", ")", "and", "endonuclease", "has", "been", "expressed", "in", "Escherichia", "coli"], "h": {"id": "C0035678", "name": "C0035678#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [8, 9]}}
{"token": ["As", "expected", ",", "B1", "receptor", "agonists", "antagonists", "and", "peptides", "non-related", "to", "BK", "such", "as", "substance", "P", "neurokinin", "A", "C1420564#ent", "<e1>", "angiotensin", "II", "bombesin", ",", "vasopressin", "and", "the", "C1367551#ent", "<e2>", "peptide", "were", "unable", "to", "compete", "with", "125I-Tyr-D-Arg-[Hyp3,D-Phe7,Leu8]BK", "."], "h": {"id": "C1420564", "name": "C1420564#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1367551", "name": "C1367551#ent", "pos": [27, 28]}}
{"token": ["Neurokinin", "A", "NKA", ")", "was", "the", "next", "most", "potent", "with", "C1420564#ent", "<e1>", "NKB", ")", "and", "calcitonin", "gene-related", "peptide", "C1367551#ent", "<e2>", ")", "the", "least", "."], "h": {"id": "C1420564", "name": "C1420564#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1367551", "name": "C1367551#ent", "pos": [18, 19]}}
{"token": ["By", "contrast", ",", "T", "cells", "CBA", "mice", "similarly", "immunized", "with", "C0034152#ent", "<e1>", "65", "produced", "high", "levels", "of", "C1334119#ent", "<e2>", "and", "IL-5", "in", "response", "to", "C0034152#ent", "<e1>", "65", "."], "h": {"id": "C0034152", "name": "C0034152#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334119", "name": "C1334119#ent", "pos": [17, 18]}}
{"token": ["Partial", "or", "complete", "deletion", "of", "several", "coronavirus", "nonstructural", "proteins", "nsps", ")", ",", "including", "C0079941#ent", "<e1>", "nsp2", ",", "results", "in", "viable", "C1564139#ent", "<e2>", "specific", "replication", "defects", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1564139", "name": "C1564139#ent", "pos": [20, 21]}}
{"token": ["The", "overactivity", "of", "subthalamopallidal", "and", "corticostriatal", "glutamatergic", "neurons", "observed", "in", "Parkinson's", "disease", "PD", ")", "suggests", "that", "antagonists", "of", "C1415287#ent", "<e1>", "be", "used", "to", "alleviate", "the", "C0426980#ent", "<e2>", "the", "disease", "."], "h": {"id": "C1415287", "name": "C1415287#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0426980", "name": "C0426980#ent", "pos": [25, 26]}}
{"token": ["Analysis", "of", "proximal", "TCR", "signaling", "revealed", "that", "TCR", "zeta-chain", "phosphorylation", "and", "subsequent", "zeta-associated", "protein", "of", "70", "kDa", "ZAP-70", ")", "C0033681#ent", "<e1>", "recruitment", "were", "not", "significantly", "affected", "by", "C1705969#ent", "<e2>", "engagement", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [27, 28]}}
{"token": ["The", "N-terminus", "of", "C1419618#ent", "<e1>", "was", "not", "required", "for", "C3537332#ent", "<e2>"], "h": {"id": "C1419618", "name": "C1419618#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537332", "name": "C3537332#ent", "pos": [9, 10]}}
{"token": ["Replication", "factor", "A", "C1419618#ent", "<e1>", ")", "is", "a", "C3537332#ent", "<e2>", "is", "conserved", "in", "all", "eukaryotes", "."], "h": {"id": "C1419618", "name": "C1419618#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537332", "name": "C3537332#ent", "pos": [8, 9]}}
{"token": ["Plasma", "lipoprotein(a)", "C1439335#ent", "<e1>", "levels", "are", "largely", "genetically", "determined", "by", "sequences", "linked", "to", "the", "C0079429#ent", "<e2>", "encoding", "apolipoprotein(a)", "apo(a", ")", "]", ",", "the", "distinct", "protein", "component", "C1439335#ent", "<e1>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1439335", "name": "C1439335#ent", "pos": [2, 3]}}
{"token": ["We", "examined", "the", "applicability", "of", "a", "platelet", "filter", "test", "(", "shear-dependent", "platelet", "aggregation", ")", "as", "a", "tool", ",", "to", "differentiate", "C0836924#ent", "<e1>", "cases", "with", "myeloproliferative", "disorders", "from", "secondary", "(", ")", "C3277671#ent", "<e2>", "."], "h": {"id": "C0836924", "name": "C0836924#ent", "pos": [20, 21]}, "relation": "manifestation_of", "t": {"id": "C3277671", "name": "C3277671#ent", "pos": [30, 31]}}
{"token": ["Fifty", "consecutive", "patients", "with", "C3277671#ent", "<e1>", "(", "35", "men", "and", "15", "women", ")", "were", "diagnosed", "as", "C0836924#ent", "<e2>", "PT", ")", "in", "30", "and", "C3277671#ent", "<e1>", "associated", "with", "polycythemia", "vera", "PV", ")", "in", "20", "."], "h": {"id": "C0836924", "name": "C0836924#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C3277671", "name": "C3277671#ent", "pos": [4, 5]}}
{"token": ["Furthermore", ",", "we", "demonstrate", "that", "C1417217#ent", "<e1>", "has", "transcription", "activity", "that", "C1835029#ent", "<e2>", "acts", "as", "a", "chimeric", "transcription", "factor", "the", "Moloney", "sarcoma", "virus", "long", "terminal", "repeat", "a", "synthetic", "promoter", "TEL", "binding", "sites"], "h": {"id": "C1417217", "name": "C1417217#ent", "pos": [5, 6]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1835029", "name": "C1835029#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "show", "that", "C1314754#ent", "<e1>", "and", "its", "homologs", "APOBEC3C", "and", "C4255227#ent", "<e2>", "potent", "DNA", "mutator", "activity", "in", "an", "E.", "coli", "assay"], "h": {"id": "C1314754", "name": "C1314754#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4255227", "name": "C4255227#ent", "pos": [12, 13]}}
{"token": ["The", "simultaneous", "findings", "of", "bronchopulmonary", "lymphocytosis", "C1334103#ent", "<e1>", "patients", "with", "C0010346#ent", "<e2>", "not", "reported", "up", "to", "now", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [10, 11]}}
{"token": ["Its", "catalytic", "domain", "motifs", "typical", "for", "C0031686#ent", "<e1>", "is", "only", "distantly", "related", "with", "PP1", ",", "C1704708#ent", "<e2>", ",", "and", "PP2B", "(", "38", "-", "42", "%", "identical", "amino", "acids", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [15, 16]}}
{"token": ["Cantharidin", "and", "calyculin", "A", "natural", "toxins", "that", "are", "inhibitors", "of", "C0031686#ent", "<e1>", "2A", "(", "PPI", "and", "C1704708#ent", "<e2>", ",", "respectively", ")", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [16, 17]}}
{"token": ["Additionally", ",", "fusion", "of", "the", "3", "'", "RhoB", "untranslated", "region", "UTR", ")", "to", "a", "C0907533#ent", "<e1>", "expressed", "reporter", "gene", "serum", "and", "growth", "factor", "well", "as", "C1413947#ent", "<e2>", "expression", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413947", "name": "C1413947#ent", "pos": [25, 26]}}
{"token": ["Spontaneous", "C0085083#ent", "<e1>", "not", "been", "described", "before", ",", "except", "in", "association", "with", "C0020676#ent", "<e2>", "."], "h": {"id": "C0085083", "name": "C0085083#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "report", "that", "CIITA", "represses", "collagen", "transcription", "a", "phosphorylation-dependent", "interaction", "between", "its", "C1420122#ent", "<e1>", "co-repressor", "molecules", "as", "histone", "deacetylase", "HDAC2", ")", "and", "C1426186#ent", "<e2>", "."], "h": {"id": "C1420122", "name": "C1420122#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1426186", "name": "C1426186#ent", "pos": [23, 24]}}
{"token": ["We", "have", "shown", "that", "exposure", "of", "bovine", "aortic", "endothelial", "cells", "BAEC", ")", "to", "shear", "stress", "phosphorylation", "of", "C1328053#ent", "<e1>", "at", "S635", "and", "S1179", "by", "the", "C0033640#ent", "<e2>", "PKA-", ")", "dependent", "mechanisms", "."], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [25, 26]}}
{"token": ["These", "results", "suggest", "that", "somatostatin", "and", "dopamine", "may", "serve", "as", "negative", "regulators", "of", "C1418938#ent", "<e1>", "and", "that", "extracellular", "Ca(2+)", "influx", "and", "C1259877#ent", "<e2>", "activation", "may", "be", "important", "signaling", "events", "prolactin", "release", "the", "goldfish", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [21, 22]}}
{"token": ["Using", "mouse", "lung", "endothelial", "cells", "C2681835#ent", "<e1>", ")", ",", "we", "examined", "the", "role", "of", "C1332397#ent", "<e2>", ")", ",", "an", "anti-apoptotic", "Bcl-2-related", "protein", "in", "H/R-induced", "cell", "death", "."], "h": {"id": "C2681835", "name": "C2681835#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [14, 15]}}
{"token": ["These", "data", "indicate", "that", "in", "mammary", "epithelial", "cells", "C1415855#ent", "<e1>", "has", "cell", "cycle", "regulatory", "functions", "are", "similar", "to", "those", "of", "C0079068#ent", "<e2>", ",", "and", "suggest", "that", "cyclin", "D1", "be", "involved", "in", "C1415855#ent", "<e1>", "regulation", "of", "cell", "cycle", "progression", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1415855", "name": "C1415855#ent", "pos": [8, 9]}}
{"token": ["In", "spleen", "cells", "cocultured", "with", "C0175702#ent", "<e1>", ",", "levels", "of", "IL-12", "and", "C1533698#ent", "<e2>", "NOS", ")", "mRNA", "expression", "were", "higher", "in", "PDC-fed", "rats", "than", "in", "NC-fed", "rats", "."], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [12, 13]}}
{"token": ["The", "interrelationship", "between", "signal-mediated", "endoplasmic", "reticulum", "retention", "control", "of", "C3814378#ent", "<e1>", "secreted", "complex", "proteins", "examined", "in", "recombinant", "293", "cells", "expressing", "C3538265#ent", "<e2>", "HuAChE", ")", "."], "h": {"id": "C3814378", "name": "C3814378#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538265", "name": "C3538265#ent", "pos": [20, 21]}}
{"token": ["Diclofenac", "metabolism", "human", "liver", "microsomes", "did", "not", "cause", "inactivation", "of", "C0608437#ent", "<e1>", ",", "a", "major", "isozyme", "involved", "in", "C0012091#ent", "<e2>", "4'-hydroxylation", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [10, 11]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [18, 19]}}
{"token": ["C0084219#ent", "<e1>", "Hck", ")", "is", "a", "C0033681#ent", "<e2>", "the", "Src", "family", "expressed", "in", "phagocytes", "as", "two", "isoforms", ",", "p59Hck", "and", "p61Hck", ",", "present", "at", "the", "plasma", "membrane", "lysosomes", ",", "respectively", "."], "h": {"id": "C0084219", "name": "C0084219#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [6, 7]}}
{"token": ["Ataxia", "telangiectasia", "A-T", ")", "is", "an", "C3899988#ent", "<e1>", "by", "loss", "of", "function", "the", "serine/threonine", "protein", "kinase", "ATM", "C3711796#ent", "<e2>", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3711796", "name": "C3711796#ent", "pos": [17, 18]}}
{"token": ["Selective", "estrogen", "receptor", "modulators", "represent", "an", "exciting", "group", "of", "C0752229#ent", "<e1>", "that", "possess", "C2987634#ent", "<e2>", "action", "on", "bone", ",", "lipids", ",", "and", "lipoproteins", "and", "antagonistic", "action", "the", "endometrium", "and", "breast", "."], "h": {"id": "C0752229", "name": "C0752229#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}}
{"token": ["All", "C0752229#ent", "<e1>", "studied", "were", "C2987634#ent", "<e2>", "in", "co-transfections", "of", "a", "collagenase", "reporter", "gene", "ERbeta", ",", "but", "tamoxifen", "alone", "was", "C2987634#ent", "<e2>", "with", "ERalpha", "in", "(", "uterine", ")", "HEC-1-A", "cells", "."], "h": {"id": "C0752229", "name": "C0752229#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}}
{"token": ["New", "agents", "such", "as", "the", "\"", "pure", "\"", "C0752229#ent", "<e1>", "and", "the", "gonadotropin-releasing", "hormone", "GnRH", ")", "C2987634#ent", "<e2>", ",", "are", "being", "tested", "."], "h": {"id": "C0752229", "name": "C0752229#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [16, 17]}}
{"token": ["Modifications", "of", "Arl2", "expression", "levels", "were", "also", "associated", "with", "altered", "phosphorylation", "status", "and/or", "cellular", "sublocalization", "certain", "C1704708#ent", "<e1>", "targets", "such", "as", "p53", ",", "a", "key", "mediator", "of", "C0549410#ent", "<e2>"], "h": {"id": "C1704708", "name": "C1704708#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0549410", "name": "C0549410#ent", "pos": [27, 28]}}
{"token": ["When", "the", "molecular", "characteristics", "Torpedo", "brain", "C0010287#ent", "<e1>", "compared", ",", "the", "C0027203#ent", "<e2>", "positioned", "at", "a", "more", "basic", "pH", "during", "chromatofocusing", "and", "on", "two-dimensional", "gel", "electrophoresis", "pI", "=", "7.5", "-", "7.9", ")", "."], "h": {"id": "C0010287", "name": "C0010287#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["Very", "low", "concentrations", "decreased", "the", "C0010287#ent", "<e1>", "release", ",", "whereas", "higher", "concentrations", "themselves", "provoked", "an", "C0027203#ent", "<e2>", "release", "."], "h": {"id": "C0010287", "name": "C0010287#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["It", "is", "often", "associated", "with", "C0004364#ent", "<e1>", "such", "as", "C0578870#ent", "<e2>"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0578870", "name": "C0578870#ent", "pos": [9, 10]}}
{"token": ["Terminal", "C1823555#ent", "<e1>", "TUTases", ")", "are", "functionally", "and", "structurally", "diverse", "C0035673#ent", "<e2>", "catalyze", "template-independent", "3", "'", "uridylylation", "of", "RNAs", "."], "h": {"id": "C1823555", "name": "C1823555#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035673", "name": "C0035673#ent", "pos": [10, 11]}}
{"token": ["The", "effectiveness", "of", "intravenously", "administered", "lidocaine", "for", "rapid", "control", "of", "C0151740#ent", "<e1>", "compared", "to", "the", "effectiveness", "of", "C0936073#ent", "<e2>", "in", "20", "patients", "with", "brain", "tumors", "craniotomy", "."], "h": {"id": "C0151740", "name": "C0151740#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [17, 18]}}
{"token": ["Validated", "methods", "C0151740#ent", "<e1>", "fulminant", "hepatic", "failure", "patients", "mainly", "include", "mannitol", ",", "hypertonic", "saline", "indomethacin", ",", "C0936073#ent", "<e2>", ",", "and", "hyperventilation", "."], "h": {"id": "C0151740", "name": "C0151740#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "with", "chronic", "heart", "failure", "C0019099#ent", "<e1>", ")", ",", "it", "remains", "unclear", "whether", "perindopril", "is", "more", "C0007209#ent", "<e2>", "than", "enalapril", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [17, 18]}}
{"token": ["Conspecific", "song", "induces", "a", "prompt", "increase", "in", "the", "expression", "of", "the", "C1418457#ent", "<e1>", "the", "caudo-medial", "neostriatum", "(", "C2681389#ent", "<e2>", ")", ",", "a", "part", "of", "the", "auditory", "telencephalon", "of", "songbirds", "."], "h": {"id": "C1418457", "name": "C1418457#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2681389", "name": "C2681389#ent", "pos": [17, 18]}}
{"token": ["Agarose-chymotrypsin", "was", "stable", "over", "the", "range", "C1415286#ent", "<e1>", "-", "9", ",", "but", "agarose-rennin", "released", "active", "C0027203#ent", "<e2>", "into", "solution", "at", "above", "C1415286#ent", "<e1>", "and", "aminoethylcellulose-rennin", "was", "similarly", "unstable", "at", "certain", "pH", "values", "."], "h": {"id": "C1415286", "name": "C1415286#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["C0038565#ent", "<e1>", ",", "intrahepatic", ",", "and", "C0000833#ent", "<e2>", "have", "a", "high", "incidence", "of", "accompanying", "pleural", "effusion"], "h": {"id": "C0038565", "name": "C0038565#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [6, 7]}}
{"token": ["Sequence", "data", "suggested", "that", "reverse", "gyrases", "composed", "of", "two", "putative", "domains", ",", "a", "C1309084#ent", "<e1>", "and", "a", "C1458146#ent", "<e2>", "usually", "in", "a", "single", "polypeptide"], "h": {"id": "C1309084", "name": "C1309084#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [17, 18]}}
{"token": ["This", "site", "binds", "specifically", "to", "bacterially", "expressed", "C0919496#ent", "<e1>", "as", "well", "as", "to", "multiple", "proteins", "including", "C0919496#ent", "<e1>", ",", "present", "in", "C1413240#ent", "<e1>", "and", "HeLa", "cell", "extracts", "."], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [21, 22]}}
{"token": ["During", "pregnancy", "the", "mother", "was", "treated", "with", "diphenylhydantoin", "and", "C0033148#ent", "<e1>", "for", "psychomotor", "and", "C0595948#ent", "<e2>"], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0595948", "name": "C0595948#ent", "pos": [14, 15]}}
{"token": ["Re-feeding", "of", "previously", "starved", "rats", "on", "a", "high-carbohydrate", "diet", "for", "16", "h", "restored", "both", "the", "specific", "activities", "of", "C0162449#ent", "<e1>", "and", "its", "susceptibility", "to", "inhibition", "by", "ATP", "to", "normal", "values", "C0342895#ent", "<e2>", "rats", "."], "h": {"id": "C0162449", "name": "C0162449#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [30, 31]}}
{"token": ["Higher", "C0162449#ent", "<e1>", "and", "lower", "glucose-6-phosphatase", "activity", "was", "found", "in", "fish", "C0342895#ent", "<e2>", "the", "starch", "diet", "in", "fish", "C0342895#ent", "<e2>", "the", "glucose", "diet", "of", "the", "time", "and", "level", "of", "chromic", "oxide", "inclusion", "."], "h": {"id": "C0162449", "name": "C0162449#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [11, 12]}}
{"token": ["Together", ",", "these", "data", "suggest", "that", "C1705517#ent", "<e1>", "is", "an", "important", "component", "of", "the", "innate", "immune", "response", "cells", "to", "C0042769#ent", "<e2>", "leading", "to", "enhanced", "cellular", "apoptosis", "may", "play", "a", "role", "in", "limiting", "viral", "dissemination"], "h": {"id": "C1705517", "name": "C1705517#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [19, 20]}}
{"token": ["One", "gene", "encoding", "GILZ", "(", "glucocorticoid-induced", "leucine", "zipper", "protein", ",", "a", "putative", "C1425411#ent", "<e1>", "is", "rapidly", "down-regulated", "by", "C2936882#ent", "<e2>", "in", "these", "cells", "."], "h": {"id": "C1425411", "name": "C1425411#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [18, 19]}}
{"token": ["The", "plasma", "concentration-response", "relationship", "of", "C0015056#ent", "<e1>", "was", "not", "affected", "by", "C0724709#ent", "<e2>", ",", "but", "there", "was", "a", "small", "decrease", "in", "the", "area", "under", "the", "anticoagulant", "effect", "vs.", "time", "curve"], "h": {"id": "C0015056", "name": "C0015056#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [11, 12]}}
{"token": ["However", ",", "the", "subjects", "differed", "with", "respect", "to", "the", "elimination", "kinetics", "of", "C0015056#ent", "<e1>", "and", "the", "effect", "of", "C0724709#ent", "<e2>", "on", "some", "of", "the", "measured", "pharmacokinetic", "paramaters"], "h": {"id": "C0015056", "name": "C0015056#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [18, 19]}}
{"token": ["This", "report", "describes", "the", "pathological", "changes", "observed", "in", "the", "brain", "of", "a", "18-year-old", "patient", "who", "died", "with", "C0022336#ent", "<e1>", "CJD", ")", "of", "the", "C0751837#ent", "<e2>", "and", "panencephalopathic", "type", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0751837", "name": "C0751837#ent", "pos": [23, 24]}}
{"token": ["We", "describe", "a", "patient", "with", "Creutzfeldt-Jakob", "disease", "C0022336#ent", "<e1>", ")", "of", "the", "C0751837#ent", "<e2>", "and", "panencephalopathic", "type", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0751837", "name": "C0751837#ent", "pos": [12, 13]}}
{"token": ["This", "report", "describes", "the", "pathological", "changes", "observed", "in", "the", "brain", "of", "a", "18-year-old", "patient", "who", "died", "with", "Creutzfeldt-Jakob", "disease", "C0022336#ent", "<e1>", ")", "of", "the", "C0751837#ent", "<e2>", "and", "panencephalopathic", "type", "."], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [19, 20]}, "relation": "has_manifestation", "t": {"id": "C0751837", "name": "C0751837#ent", "pos": [24, 25]}}
{"token": ["Werner", "syndrome", "patients", "are", "deficient", "in", "the", "C0388246#ent", "<e1>", "WRN", ")", ",", "which", "is", "a", "multifunctional", "nuclear", "protein", "C0950448#ent", "<e2>", "ATP-dependent", "helicase", "activities", "."], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0950448", "name": "C0950448#ent", "pos": [18, 19]}}
{"token": ["The", "gene", "mutated", "WS", "encodes", "a", "nuclear", "protein", "C0388246#ent", "<e1>", ")", "which", "possesses", "C0950448#ent", "<e2>", "ATPase-dependent", "3'-5", "'", "helicase", "activities", "."], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0950448", "name": "C0950448#ent", "pos": [13, 14]}}
{"token": ["Application", "of", "juvenile", "hormone", "analogue", "C0878203#ent", "<e1>", ")", "prevented", "the", "effect", "of", "benserazid", "on", "the", "C0018050#ent", "<e2>", "of", "the", "crickets", "."], "h": {"id": "C0878203", "name": "C0878203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [15, 16]}}
{"token": ["All", "three", "patients", "had", "previously", "documented", "autoimmune", "disease", "i.e.", ",", "auto-immune", "thrombopenia", ",", "multiple", "auto-immune", "disease", "(", "comprising", "C0151449#ent", "<e1>", "polymyositis", "and", "C0042900#ent", "<e2>", ")", ",", "and", "C0151449#ent", "<e1>"], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [22, 23]}}
{"token": ["C0026946#ent", "<e1>", "the", "various", "forms", "of", "C0040247#ent", "<e2>", "and", "are", "usually", "treated", "with", "topical", "antifungals", "if", "the", "infection", "is", "located", "in", "a", "hair-bearing", "area", ",", "systemic", "antifungals", "necessary", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [6, 7]}}
{"token": ["This", "article", "discusses", "causes", ",", "symptoms", ",", "diagnosis", ",", "and", "treatment", "of", "the", "most", "common", "C0026946#ent", "<e1>", "the", "perionychium", ",", "including", "C0040247#ent", "<e2>", "onychomycosis", ",", "and", "chronic", "paronychia"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [21, 22]}}
{"token": ["COL4A3", ",", "C1413585#ent", "<e1>", ",", "and", "COL4A5", "are", "the", "only", "C0009325#ent", "<e2>", "have", "been", "implicated", "in", "inherited", "nephropathies", "in", "humans", "."], "h": {"id": "C1413585", "name": "C1413585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "the", "forkhead", "transcription", "factor", "gene", "2", "FOXL2", ")", "were", "recently", "reported", "to", "cause", "blepharophimosis-ptosis-epicanthus", "inversus", "syndrome", "C2700050#ent", "<e1>", ")", "types", "I", "and", "C3273406#ent", "<e2>", "."], "h": {"id": "C2700050", "name": "C2700050#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [24, 25]}}
{"token": ["Therefore", ",", "C1101838#ent", "<e1>", "is", "considered", "to", "have", "little", "interaction", "with", "drugs", "through", "C0010762#ent", "<e2>", "."], "h": {"id": "C1101838", "name": "C1101838#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "differential", "diagnosis", "some", "treatable", "dementias", "among", "the", "most", "common", "diseases", "(", "Alzheimer", "and", "C0011269#ent", "<e1>", "such", "as", "herpes", "encephalitis", "multiple", "sclerosis", "C0393639#ent", "<e2>", "particularly", "in", "the", "younger", "age", "group"], "h": {"id": "C0011269", "name": "C0011269#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0393639", "name": "C0393639#ent", "pos": [24, 25]}}
{"token": ["C0002066#ent", "<e1>", "is", "a", "rare", ",", "autosomal-recessive", ",", "C0950123#ent", "<e2>", ",", "metabolic", "disease", "causes", "ochronotic", "arthropathy", "to", "disabling", "arthritis", "."], "h": {"id": "C0002066", "name": "C0002066#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0950123", "name": "C0950123#ent", "pos": [8, 9]}}
{"token": ["C0002066#ent", "<e1>", "a", "rare", "C0950123#ent", "<e2>", "metabolic", "disorder"], "h": {"id": "C0002066", "name": "C0002066#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0950123", "name": "C0950123#ent", "pos": [4, 5]}}
{"token": ["In", "conclusion", ",", "we", "demonstrated", "that", "those", "older", "hypertensives", "the", "C3273406#ent", "<e1>", "genotype", "have", "the", "greatest", "improvement", "in", "insulin", "action", "C3540525#ent", "<e2>", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540525", "name": "C3540525#ent", "pos": [20, 21]}}
{"token": ["The", "C0240940#ent", "<e1>", "is", "frequently", "involved", "in", "the", "C0004364#ent", "<e2>"], "h": {"id": "C0240940", "name": "C0240940#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [8, 9]}}
{"token": ["The", "cause", "of", "thyroidal", "defect", "in", "our", "patient", "is", "not", "considered", "to", "be", "autoimmune", "hyperthyroidism", "but", "hyperthyroidism", "due", "to", "constitutive", "activation", "of", "C2703069#ent", "<e1>", "by", "inhibition", "of", "its", "C0018296#ent", "<e2>", "."], "h": {"id": "C2703069", "name": "C2703069#ent", "pos": [22, 23]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [28, 29]}}
{"token": ["In", "humans", ",", "heterozygous", "mutations", "the", "C1418276#ent", "<e1>", "aniridia", "(", "absence", "of", "the", "C1256254#ent", "<e2>", ")", "and", "related", "developmental", "eye", "diseases"], "h": {"id": "C1418276", "name": "C1418276#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1256254", "name": "C1256254#ent", "pos": [13, 14]}}
{"token": ["Unlike", "C0001644#ent", "<e1>", "brimonidine", "is", "not", "contraindicated", "in", "patients", "with", "C0238074#ent", "<e2>", "although", "it", "should", "be", "used", "with", "caution", "in", "individuals", "with", "severe", "cardiovascular", "disease"], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0238074", "name": "C0238074#ent", "pos": [10, 11]}}
{"token": ["In", "the", "embryo", ",", "C1705767#ent", "<e1>", "and", "ephrin-B1", "participate", "in", "C0270921#ent", "<e2>", ",", "neural", "crest", "cell", "migration", "the", "formation", "of", "blood", "vessels", "and", "the", "development", "of", "facial", "structures", "the", "inner", "ear"], "h": {"id": "C1705767", "name": "C1705767#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0270921", "name": "C0270921#ent", "pos": [10, 11]}}
{"token": ["However", ",", "few", "cases", "have", "been", "reported", "without", "recognized", "etiology", ",", "this", "C0039082#ent", "<e1>", "is", "also", "called", "C0162809#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0162809", "name": "C0162809#ent", "pos": [17, 18]}}
{"token": ["Males", "with", "deletions", "of", "or", "within", "Xp22.3-pter", "display", "variable", "contiguous", "C0039082#ent", "<e1>", "manifestations", "of", "L\u00e9ri-Weill", "syndrome", "chondrodysplasia", "punctata", "mental", "retardation", "ichthyosis", ",", "C0162809#ent", "<e2>", "and", "ocular", "albinism"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0162809", "name": "C0162809#ent", "pos": [22, 23]}}
{"token": ["Inhibition", "of", "endogenous", "NO", "synthesis", "with", "C0068821#ent", "<e1>", "blocking", "soluble", "guanylate", "cyclase", "C0010536#ent", "<e2>", "delayed", "but", "did", "not", "prevent", "the", "CO-induced", "activation", "of", "BK", "channels"], "h": {"id": "C0068821", "name": "C0068821#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [12, 13]}}
{"token": ["Expression", "of", "C1421315#ent", "<e1>", "in", "L6", "myotubes", "increased", "2-deoxyglucose", "uptake", "and", "cell", "surface", "C2982484#ent", "<e2>", "2.3-fold", ",", "thereby", "reaching", "maximally", "insulin-stimulated", "levels", "in", "control", "myotubes"], "h": {"id": "C1421315", "name": "C1421315#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [13, 14]}}
{"token": ["Wortmannin", ",", "LY", "294002", ",", "or", "the", "tyrosine", "kinase", "inhibitor", "genistein", "abolished", "the", "effect", "of", "C1421315#ent", "<e1>", "on", "glucose", "uptake", "and", "wortmannin", "inhibited", "UCP3-induced", "C2982484#ent", "<e2>", "cell", "surface", "recruitment", "."], "h": {"id": "C1421315", "name": "C1421315#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [24, 25]}}
{"token": ["We", "have", "found", "that", "the", "major", "M.", "tuberculosis", "cell", "wall", "glycolipid", "phosphatidylinositol", "mannoside", "C1709403#ent", "<e1>", ")", ",", "induces", "homotypic", "adhesion", "human", "CD4+", "T", "cells", "T", "cell", "adhesion", "immobilized", "C1367472#ent", "<e2>", "."], "h": {"id": "C1709403", "name": "C1709403#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1367472", "name": "C1367472#ent", "pos": [28, 29]}}
{"token": ["injection", "of", "C0026056#ent", "<e1>", ",", "fentanyl", ",", "and", "C0125656#ent", "<e2>", ",", "intubated", ",", "and", "ventilated", "for", "3h", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0125656", "name": "C0125656#ent", "pos": [8, 9]}}
{"token": ["To", "evaluate", "the", "effects", "of", "intranasal", "administration", "C0026056#ent", "<e1>", "and", "xylazine", "(", "with", "or", "without", "ketamine", ")", "and", "C0125656#ent", "<e2>", "and", "their", "specific", "antagonists", "in", "parakeets", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0125656", "name": "C0125656#ent", "pos": [18, 19]}}
{"token": ["In", "the", "presence", "of", "a", "converting", "enzyme", "inhibitor", "C0733566#ent", "<e1>", ")", ",", "the", "angiotensin", "I", "not", "converted", "into", "angiotensin", "II", "but", "C1537501#ent", "<e2>", "was", "still", "inactivated", ",", "although", "the", "speed", "of", "inactivation", "was", "decreased", "."], "h": {"id": "C0733566", "name": "C0733566#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [21, 22]}}
{"token": ["When", "C3539616#ent", "<e1>", "and", "gL", "were", "co-expressed", "some", "C0149678#ent", "<e2>", "C3539616#ent", "<e1>", "was", "transported", "to", "the", "insect", "cell", "surface"], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [8, 9]}}
{"token": ["This", "is", "the", "first", "demonstration", "that", "C0286651#ent", "<e1>", "can", "delay", "the", "progression", "of", "a", "C0004364#ent", "<e2>", "may", "specifically", "benefit", "patients", "with", "systemic", "lupus", "erythematosus"], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [14, 15]}}
{"token": ["Conversely", ",", "perinatal", "C1705616#ent", "<e1>", "exposure", "reduced", "heroin-induced", "Fos-IR", "in", "the", "C1622105#ent", "<e2>", "(", "shell", ")", ",", "BNST", ",", "CEA", ",", "dorsolateral", "and", "lateral", "PAG", ",", "VTA", ",", "and", "EW", "."], "h": {"id": "C1705616", "name": "C1705616#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [11, 12]}}
{"token": ["C0539969#ent", "<e1>", "and", "descarboethoxy", "C0065180#ent", "<e2>", ",", "the", "metabolites", "of", "astemizole", "and", "C0065180#ent", "<e2>", ",", "respectively", ",", "are", "also", "in", "clinical", "development"], "h": {"id": "C0539969", "name": "C0539969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0065180", "name": "C0065180#ent", "pos": [4, 5]}}
{"token": ["Mobility", "shift", "assays", "significant", "C0919496#ent", "<e1>", "binding", "of", "the", "novel", "sites", "as", "compared", "to", "C3470429#ent", "<e2>", ",", "erbB-2", "and", "hMtIIa", "sites", "."], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [14, 15]}}
{"token": ["Activator", "protein", "2", "C0919496#ent", "<e1>", ")", "is", "a", "DNA-binding", "transcription", "factor", "can", "activate", "the", "expression", "of", "C3470429#ent", "<e2>", "(", "waf1/cip1", ")", ",", "which", "in", "turn", "causes", "growth", "arrest", "cells", "through", "inhibition", "of", "cyclin-dependent", "kinases", "in", "G1-S", "progression", "."], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [16, 17]}}
{"token": ["Diabetics", "with", "severe", "periodontal", "disease", "however", ",", "showed", "a", "higher", "prevalence", "of", "C0035086#ent", "<e1>", "cardiovascular", "complications", "as", "stroke", ",", "transient", "C0007787#ent", "<e2>", "angina", ",", "myocardial", "infarct", "heart", "failure", "and", "claudicatio", "intermittens", "diabetics", "with", "only", "minor", "periodontal", "disease"], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [20, 21]}}
{"token": ["Among", "these", "C0017337#ent", "<e1>", ",", "we", "found", "that", "C1846414#ent", "<e2>", "transcriptionally", "down-regulated", "by", "bovine", "and", "human", "LFs", ",", "but", "not", "by", "human", "transferrin", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1846414", "name": "C1846414#ent", "pos": [8, 9]}}
{"token": ["We", "found", "simultaneous", "induction", "of", "both", "C1524023#ent", "<e1>", "and", "its", "C1335671#ent", "<e2>", "by", "interleukin-6", "(", "IL-6", ")", "in", "primary", "cultured", "rat", "glomerular", "mesangial", "cells"], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335671", "name": "C1335671#ent", "pos": [10, 11]}}
{"token": ["These", "episodes", "of", "simple", "partial", "C1414863#ent", "<e1>", "then", "evolved", "to", "a", "C0149958#ent", "<e2>", "CPS", ")", "or", "secondarily", "generalized", "seizure"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149958", "name": "C0149958#ent", "pos": [11, 12]}}
{"token": ["Cuyahoga", "Falls", "General", "Hospital", "was", "surprised", "when", "redesigning", "the", "way", "patients", "are", "identified", "as", "candidates", "for", "C0256103#ent", "<e1>", "and", "other", "thrombolytic", "drug", "therapies", "in", "fewer", "admissions", "for", "complicated", "C0027051#ent", "<e2>"], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [28, 29]}}
{"token": ["A", "single", "VAS", "value", "for", "drowsiness", "is", "a", "good", "instrument", "for", "evaluating", "C0015672#ent", "<e1>", "for", "measuring", "the", "clinical", "effect", "treatment", "in", "C0037384#ent", "<e2>", "."], "h": {"id": "C0015672", "name": "C0015672#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0037384", "name": "C0037384#ent", "pos": [21, 22]}}
{"token": ["Because", "C0002763#ent", "<e1>", "are", "known", "to", "induce", "conditioned", "place", "preference", "C1413682#ent", "<e2>", ")", ",", "the", "C1413682#ent", "<e2>", "procedure", "was", "used", "to", "test", "the", "hypothesis", "that", "cocaine", "and", "MgCl2", "share", "similar", "stimulus", "properties", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [10, 11]}}
{"token": ["2", "hours", ")", "caused", "significant", "increases", "in", "olfactory", "bulb", "C0001614#ent", "<e1>", ",", "hippocampus", ",", "thalamus", "and", "cerebellum", ",", "whereas", "C0042291#ent", "<e2>", "(", "200", "mg/kg", "i.p", ".", ","], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "indicate", "that", "C0950779#ent", "<e1>", "should", "be", "a", "potentially", "beneficial", "C1254351#ent", "<e2>", "to", "be", "used", "in", "the", "treatment", "of", "osteolytic", "metastasis"], "h": {"id": "C0950779", "name": "C0950779#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}}
{"token": ["Although", "this", "effect", "is", "relatively", "weak", ",", "it", "has", "a", "strong", "C0034541#ent", "<e1>", "action", "on", "GnRH-induced", "C3536870#ent", "<e2>", "secretion", "."], "h": {"id": "C0034541", "name": "C0034541#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3536870", "name": "C3536870#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "whether", "C0011777#ent", "<e1>", "administered", "before", "or", "after", "allergen", "challenge", "inhibit", "the", "C3714636#ent", "<e2>", "airway", "hyperresponsiveness", "a", "mouse", "model", "asthma", "induced", "by", "a", "house", "dust", "extract", "high", "levels", "of", "cockroach", "allergens"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [13, 14]}}
{"token": ["In", "the", "chromogenic", "substrate", "assay", "Hageman", "factor", "inhibitor", "CHFI", ")", "inhibited", "the", "activation", "of", "C0950385#ent", "<e1>", "cleaving", "enzyme", "by", "GAGPS", ",", "C0524684#ent", "<e2>", "polyanethol", "sulfate", "heparin", ",", "and", "ribonucleic", "acid", "completely", "."], "h": {"id": "C0950385", "name": "C0950385#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0524684", "name": "C0524684#ent", "pos": [21, 22]}}
{"token": ["To", "study", "the", "relationship", "between", "bile", "acid", "biosynthesis", "triglyceride", "metabolism", "we", "cross-bred", "mice", "lacking", "C1413893#ent", "<e1>", "on", "a", "C0020473#ent", "<e2>", "APOE*3-Leiden", "background", "."], "h": {"id": "C1413893", "name": "C1413893#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [18, 19]}}
{"token": ["The", "aim", "of", "this", "work", "was", "to", "determine", "more", "precisely", "the", "potential", "role", "of", "C0122926#ent", "<e1>", "HA", ")", ",", "an", "C0014442#ent", "<e2>", "secreted", "by", "the", "larvae", ",", "in", "this", "immunosuppression", "."], "h": {"id": "C0122926", "name": "C0122926#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}}
{"token": ["These", "included", "a", "cluster", "of", "interferon-regulated", "genes", "and", "C1336639#ent", "<e1>", ",", "as", "well", "many", "less-well", "characterized", "C1417679#ent", "<e2>", "which", "are", "candidates", "for", "further", "study", "."], "h": {"id": "C1336639", "name": "C1336639#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["The", "Y", "chromosome-linked", "genomic", "modifier", "Yaa", ",", "which", "correlates", "with", "a", "duplication", "of", "C1336639#ent", "<e1>", "and", "16", "other", "C1417679#ent", "<e2>", ",", "exacerbates", "lupus-like", "syndromes", "several", "mouse", "strains", "."], "h": {"id": "C1336639", "name": "C1336639#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["Consistent", "with", "lower", "serum", "testosterone", "levels", ",", "C0032002#ent", "<e1>", "Lhb", "and", "C1414824#ent", "<e2>", "mRNA", "levels", "were", "increased", "3.2-", "and", "2.3-fold", ",", "respectively", ",", "by", "CDB-4022", "treatment", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414824", "name": "C1414824#ent", "pos": [11, 12]}}
{"token": ["One", "genetic", "polymorphism", "G-->A", ",", "Arg-->Gln", "at", "codon", "399", ")", "occurs", "within", "a", "C0032405#ent", "<e1>", "within", "the", "central", "breast", "cancer", "susceptibility", "gene", "1", "COOH", "terminus", "domain", "of", "C1366475#ent", "<e2>", "."], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366475", "name": "C1366475#ent", "pos": [27, 28]}}
{"token": ["Here", "we", "report", "a", "systematic", "analysis", "the", "effects", "of", "in", "vitro", "oxidation", "in", "the", "absence", "and", "presence", "of", "an", "C0914069#ent", "<e1>", "on", "the", "phosphatidylcholine", "(", "C3811118#ent", "<e2>", ")", "composition", "of", "human", "LDL", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [25, 26]}}
{"token": ["Results", "obtained", "in", "this", "study", "suggest", "that", "in", "human", "brucellosis", "there", "is", "an", "antibody", "response", "C0914069#ent", "<e1>", "PAF", ")", "and", "phosphatidylcholine", "(", "C3811118#ent", "<e2>", ")", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [22, 23]}}
{"token": ["Intrathecal", "injection", "a", "specific", "inhibitor", "of", "C0872913#ent", "<e1>", "decreased", "electrical", "stimulation-induced", "C0087140#ent", "<e2>", "expression", "in", "dorsal", "horn", "neurons", "following", "axotomy", ",", "and", "also", "prevented", "the", "development", "of", "thermal", "hyperalgesia", "partial", "sciatic", "nerve", "ligation"], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [11, 12]}}
{"token": ["We", "found", "a", "marked", "synergistic", "interaction", "between", "C0872913#ent", "<e1>", "and", "a", "transfected", "v-Ha-ras", "oncogene", "the", "activation", "of", "C0087140#ent", "<e2>", "SRE", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [17, 18]}}
{"token": ["A", "new", "form", "of", "C3713420#ent", "<e1>", "been", "described", ",", "C3838731#ent", "<e2>", "linkage", "analysis", "direct", "mutation", "screening", "has", "shown", "that", "this", "disorder", "is", "unrelated", "to", "mutations", "in", "the", "genes", "for", "aldosterone", "synthase", "the", "angiotensin", "II", "receptor"], "h": {"id": "C3713420", "name": "C3713420#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C3838731", "name": "C3838731#ent", "pos": [9, 10]}}
{"token": ["The", "dysthrombin", ",", "C0145770#ent", "<e1>", "is", "chromatographically", "separable", "into", "two", "components", "designated", "Thrombin", "Quick", "I", "C0145771#ent", "<e2>"], "h": {"id": "C0145770", "name": "C0145770#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0145771", "name": "C0145771#ent", "pos": [15, 16]}}
{"token": ["The", "efficacy", "of", "C3274828#ent", "<e1>", "depended", "on", "C2926735#ent", "<e2>", "of", "hypoxia", "and", "was", "associated", "with", "intracellular", "GSH", "concentration", ",", "an", "effect", "partly", "mediated", "via", "increased", "glutathione", "reductase", "activity"], "h": {"id": "C3274828", "name": "C3274828#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [7, 8]}}
{"token": ["C0033405#ent", "<e1>", "is", "used", "to", "treat", "C0026603#ent", "<e2>", "Space", "Adaptation", "Syndrome", "but", "there", "is", "incomplete", "information", "about", "how", "it", "affects", "vestibular", "and", "optokinetic", "responses"], "h": {"id": "C0033405", "name": "C0033405#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [6, 7]}}
{"token": ["Moreover", ",", "the", "antiestrogen", "tamoxifen", "the", "stimulation", "of", "MC3T3-E1", "cells", "on", "the", "proliferation", "and", "C1424288#ent", "<e1>", "activity", "by", "C0073096#ent", "<e2>", "."], "h": {"id": "C1424288", "name": "C1424288#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0073096", "name": "C0073096#ent", "pos": [18, 19]}}
{"token": ["C1161352#ent", "<e1>", "dose-dependently", "produced", "analgesia", ",", "no", "effect", "C0020429#ent", "<e2>", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [8, 9]}}
{"token": ["To", "date", ",", "three", "loci", "have", "been", "linked", "to", "this", "syndrome", ",", "and", "recently", ",", "the", "gene", "encoding", "ataxia-telangiectasia", "and", "C3711837#ent", "<e1>", "ATR", ")", "was", "identified", "as", "the", "gene", "mutated", "the", "C0265202#ent", "<e2>"], "h": {"id": "C3711837", "name": "C3711837#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0265202", "name": "C0265202#ent", "pos": [31, 32]}}
{"token": ["Three", "groups", "of", "11", "Balb/c", "mice", "three", "injection", "of", "either", "C1366837#ent", "<e1>", ",", "the", "empty", "expression", "vector", "(", "C1705930#ent", "<e2>", ")", "or", "PBS", "."], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705930", "name": "C1705930#ent", "pos": [18, 19]}}
{"token": ["The", "phosphorylation", "did", "not", "require", "glycogen", "synthase", "kinase", "3beta", "instead", "required", "C0752519#ent", "<e1>", "which", "bound", "directly", "to", "C1705717#ent", "<e2>", "."], "h": {"id": "C0752519", "name": "C0752519#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705717", "name": "C1705717#ent", "pos": [17, 18]}}
{"token": ["Casein", "kinase", "C0752519#ent", "<e1>", "colocalizes", "with", "dishevelled", "along", "actin", "fibers", "in", "the", "perinuclear", "region", "whereas", "C1705717#ent", "<e2>", "and", "GSK-3", "are", "only", "present", "around", "the", "nucleus", "."], "h": {"id": "C0752519", "name": "C0752519#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705717", "name": "C1705717#ent", "pos": [15, 16]}}
{"token": ["UA", "increased", "the", "protein", "release", "IL-1beta", ",", "IL-6", ",", "and", "C1412384#ent", "<e1>", ",", "but", "not", "of", "C1710304#ent", "<e2>", ",", "in", "dose-", "and", "time-dependent", "manners", "."], "h": {"id": "C1412384", "name": "C1412384#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [16, 17]}}
{"token": ["Macrophage", "migration", "inhibitory", "factor", "C1412384#ent", "<e1>", ")", "is", "a", "potent", "proinflammatory", "cytokine", "that", "may", "induce", "C1710304#ent", "<e2>", "release", "and", "play", "an", "important", "role", "in", "innate", "immune", "inflammatory", "responses"], "h": {"id": "C1412384", "name": "C1412384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "C1412384#ent", "<e1>", "deletion", "affected", "the", "production", "of", "IL-18", ",", "C1710304#ent", "<e2>", ",", "IL-1beta", ",", "and", "iNOS", "in", "the", "islets", "of", "Langerhans", "."], "h": {"id": "C1412384", "name": "C1412384#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [11, 12]}}
{"token": ["However", ",", "GSNO-treated", "C1434639#ent", "<e1>", "does", "not", "affect", "the", "JNK2", "activity", "of", "C0031727#ent", "<e2>", "toward", "c-Jun", "N-terminal1", "-", "79", "protein", "."], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}}
{"token": ["The", "objective", "of", "this", "research", "was", "to", "evaluate", "the", "association", "between", "the", "response", "of", "C0030883#ent", "<e1>", "neurologic", "outcomes", "in", "C0038220#ent", "<e2>"], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [19, 20]}}
{"token": ["Ten", "EEGs", "from", "10", "patients", "with", "hypoxic-ischemic", "encephalopathy", "HIE-BS", ")", "and", "21", "records", "from", "8", "patients", "with", "C0030883#ent", "<e1>", "induced", "burst-suppression", "for", "treatment", "of", "C0038220#ent", "<e2>", "SE-BS", ")", "were", "reviewed", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [24, 25]}}
{"token": ["C1332414#ent", "<e1>", "was", "identified", "as", "the", "C1256818#ent", "<e2>", "ASK1", "ubiquitination", ",", "and", "studies", "with", "primary", "B", "cells", "C1332414#ent", "<e1>", "knock-out", "animals", "that", "C1332414#ent", "<e1>", "is", "required", "for", "TNFR2-induced", "TRAF2", "and", "ASK1", "degradation", "."], "h": {"id": "C1332414", "name": "C1332414#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1256818", "name": "C1256818#ent", "pos": [6, 7]}}
{"token": ["Using", "these", "tests", ",", "a", "comparison", "was", "made", "of", "the", "effects", "of", "C2697656#ent", "<e1>", "those", "of", "an", "Ab", "inhibitor", "occurring", "in", "C0042974#ent", "<e2>"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042974", "name": "C0042974#ent", "pos": [21, 22]}}
{"token": ["The", "effects", "of", "C0304512#ent", "<e1>", "naftopidil", "and", "C0114873#ent", "<e2>", "on", "platelet", "aggregation", "investigated", "."], "h": {"id": "C0304512", "name": "C0304512#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0114873", "name": "C0114873#ent", "pos": [7, 8]}}
{"token": ["Among", "the", "study", "subjects", "55", "CAD", "patients", "and", "73", "controls", "were", "evaluated", "at", "random", "for", "response", "to", "activated", "C1418943#ent", "<e1>", "APC", ")", "by", "C0600433#ent", "<e2>"], "h": {"id": "C1418943", "name": "C1418943#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0600433", "name": "C0600433#ent", "pos": [23, 24]}}
{"token": ["C0012694#ent", "<e1>", "effective", "in", "relieving", "C0231918#ent", "<e2>", "is", "the", "prototype", "of", "a", "new", "noncorticosteroidal", "class", "of", "compounds", "termed", "antiallergy", "drugs"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0231918", "name": "C0231918#ent", "pos": [5, 6]}}
{"token": ["Myocardial", "ischaemia", "reperfusion", "in", "untreated", "rats", "decreased", "survival", "rate", "produced", "a", "marked", "myocardial", "necrosis", "increased", "serum", "creatine", "phosphokinase", "activity", "and", "cardiac", "myeloperoxidase", "activity", "a", "marker", "C0027203#ent", "<e1>", "commonly", "used", "to", "assess", "C0064833#ent", "<e2>", "accumulation", ")", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [31, 32]}}
{"token": ["These", "analyses", "confirm", "that", "C1417236#ent", "<e1>", "status", "is", "associated", "with", "severity", "of", "C0001962#ent", "<e2>", "and", "pentobarbital", "withdrawal", "convulsions", "."], "h": {"id": "C1417236", "name": "C1417236#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [12, 13]}}
{"token": ["The", "recently", "identified", "Janus", "kinase", "2", "C1527617#ent", "<e1>", ")", "V617F", "somatic", "mutation", "is", "closely", "related", "to", "chronic", "myeloproliferative", "disorders", "C2827469#ent", "<e2>", ")", "."], "h": {"id": "C1527617", "name": "C1527617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2827469", "name": "C2827469#ent", "pos": [19, 20]}}
{"token": ["To", "ascertain", "whether", "C1623430#ent", "<e1>", "induced", "by", "large", "T", "is", "sufficient", "to", "inhibit", "C1417574#ent", "<e2>", "c-jun", "cDNA", "transfected", "into", "C2", "cells"], "h": {"id": "C1623430", "name": "C1623430#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "quiescent", "C2", "cells", "a", "tumor", "promoter", "12-O-tetradecanoylphorbol", "13-acetate", "transiently", "induced", "C1623430#ent", "<e1>", "and", "c-fos", "mRNAs", ",", "and", "temporarily", "deinduced", "C1417574#ent", "<e2>", "and", "myogenin", "mRNAs", "just", "after", "the", "expression", "of", "the", "protooncogenes", "."], "h": {"id": "C1623430", "name": "C1623430#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [21, 22]}}
{"token": ["Plk1", "activation", ",", "therefore", ",", "takes", "place", "before", "GVBD", "and", "C1370600#ent", "<e1>", "activation", "since", "C1335227#ent", "<e2>", "correlates", "with", "its", "slow", "migrating", "phosphorylated", "form", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [14, 15]}}
{"token": ["For", "this", "approach", "to", "succeed", "in", "C0042166#ent", "<e1>", ",", "uniformity", "in", "T", "cell", "receptor", "usage", ",", "restricted", "C0024518#ent", "<e2>", "usage", "and", "limited", "epitope", "recognition", "individuals", "would", "be", "required", "."], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [17, 18]}}
{"token": ["We", "propose", "that", "C0003949#ent", "<e1>", "induces", "apoptosis", "of", "C1426677#ent", "<e2>", ",", "resulting", "in", "the", "development", "of", "an", "inflammatory", "state"], "h": {"id": "C0003949", "name": "C0003949#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1426677", "name": "C1426677#ent", "pos": [8, 9]}}
{"token": ["In", "summary", ",", "these", "results", "suggest", "that", ",", "unlike", "nonfibrogenic", "particulates", ",", "low", "doses", "C0003949#ent", "<e1>", "apoptosis", "in", "cultured", "human", "C1426677#ent", "<e2>", "that", "may", "be", "an", "early", "step", "in", "the", "development", "of", "lung", "fibrosis"], "h": {"id": "C0003949", "name": "C0003949#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1426677", "name": "C1426677#ent", "pos": [20, 21]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "therefore", "to", "evaluate", "the", "ICAM-1-shedding", "through", "measurements", "of", "sICAM-1", "concentrations", "during", "C0032950#ent", "<e1>", "treatment", "of", "C0009324#ent", "<e2>", "patients", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [22, 23]}}
{"token": ["Intraarterial", "infusion", "C0032950#ent", "<e1>", "can", "lead", "to", "improvement", "of", "C0009324#ent", "<e2>", "and", "this", "mode", "of", "therapy", "should", "be", "considered", "particularly", "in", "severe", "cases", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [9, 10]}}
{"token": ["Glucocorticoids", "(", "e.g.", "C0032950#ent", "<e1>", ")", "are", "cornerstones", "in", "the", "treatment", "of", "acute", "exacerbations", "ulcerative", "colitis", "C0009324#ent", "<e2>", ")", ",", "and", "influence", "of", "the", "leucocyte/endothelial", "interaction", "appears", "to", "be", "part", "of", "their", "mode", "of", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "a", "previously", "named", "C1138216#ent", "<e1>", "sequence", "was", "renamed", "Nek9/Nercc1", "in", "Genbank", "due", "to", "its", "lack", "of", "homology", "to", "murine", "C1138216#ent", "<e1>", "and", "its", "high", "homology", "to", "murine", "C1425629#ent", "<e1>", "."], "h": {"id": "C1138216", "name": "C1138216#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1425629", "name": "C1425629#ent", "pos": [29, 30]}}
{"token": ["The", "age", "of", "onset", "was", "significantly", "lower", "among", "patients", "with", "a", "family", "history", "C0009324#ent", "<e1>", ";", "they", "also", "had", "a", "higher", "incidence", "of", "C0009319#ent", "<e2>"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0009319", "name": "C0009319#ent", "pos": [23, 24]}}
{"token": ["In", "both", ",", "esophageal", "lesions", "associated", "with", "gastrointestinal", "manifestations", "in", "the", "first", "a", "transient", "episode", "of", "C0009324#ent", "<e1>", "and", "in", "the", "second", "C0009319#ent", "<e2>"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0009319", "name": "C0009319#ent", "pos": [22, 23]}}
{"token": ["This", "correlated", "with", "inhibition", "of", "C1434639#ent", "<e1>", "well", "as", "an", "C0033681#ent", "<e2>", "p56lck", ",", "by", "leflunomide", "."], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [10, 11]}}
{"token": ["Inhibition", "of", "IL-2", "expression", "correlated", "with", "loss", "of", "sustained", "increase", "in", "[Ca+2]i", "and", "mitogen", "activated", "protein", "kinase", "C1434639#ent", "<e1>", ")", "activity", ",", "but", "not", "with", "activation", "of", "the", "C0033681#ent", "<e2>", "lck", "."], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [17, 18]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [28, 29]}}
{"token": ["The", "kinetic", "characteristics", "of", "C2741742#ent", "<e1>", "been", "studied", "using", "C0022173#ent", "<e2>", "from", "human", "liver", "(", "X-ADH", ")", "and", "rat", "liver", "(", "ADH-2", ")", "."], "h": {"id": "C2741742", "name": "C2741742#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [9, 10]}}
{"token": ["There", "were", "fibrotic", "ducts", "and", "hepatic", "stasis", "C0023890#ent", "<e1>", "changes", "in", "the", "control", "group", "C0006982#ent", "<e2>", "ligation", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006982", "name": "C0006982#ent", "pos": [14, 15]}}
{"token": ["Depending", "on", "their", "design", ",", "these", "drugs", "may", "have", "potential", "as", "C0991617#ent", "<e1>", "for", "the", "treatment", "of", "C0018995#ent", "<e2>", "cancer", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [17, 18]}}
{"token": ["Twenty-three", "patients", "of", "greater", "than", "70", "years", "of", "age", ",", "with", "proven", "C0042029#ent", "<e1>", "treated", "with", "mg", "of", "C0014310#ent", "<e2>", "twice", "daily", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0014310", "name": "C0014310#ent", "pos": [18, 19]}}
{"token": ["Fifty-six", "patients", "with", "complicated", ",", "recurrent", "C0042029#ent", "<e1>", "entered", "in", "a", "study", "comparing", "the", "clinical", "and", "microbiological", "effectiveness", "C0014310#ent", "<e2>", "with", "that", "of", "co-trimoxazole", "(", "trimethoprim/sulphamethoxazole", ")", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0014310", "name": "C0014310#ent", "pos": [18, 19]}}
{"token": ["Endogenous", "C0015075#ent", "<e1>", "production", "was", "induced", "by", "pollination", "in", "both", "WT", "and", "C1426839#ent", "<e2>", "corollas", ",", "but", "this", "increase", "was", "delayed", "in", "C1426839#ent", "<e2>", "flowers", "."], "h": {"id": "C0015075", "name": "C0015075#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1426839", "name": "C1426839#ent", "pos": [12, 13]}}
{"token": ["C4053954#ent", "<e1>", "thought", "to", "be", "a", "mild", "form", "C0024143#ent", "<e2>"], "h": {"id": "C4053954", "name": "C4053954#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [8, 9]}}
{"token": ["Polymorphism", "was", "detected", "in", "their", "hybridization", "banding", ",", "relative", "to", "the", "C1883559#ent", "<e1>", "grown", "in", "the", "absence", "of", "chlorate", ",", "using", "various", "C3540790#ent", "<e2>", "with", "or", "without", "restriction", "sites", "the", "retrotransposon", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [22, 23]}}
{"token": ["Kinetic", "analysis", "the", "C1883559#ent", "<e1>", "the", "mutant", "C3540790#ent", "<e2>", "revealed", "that", "both", "methionine-207", "and", "isoleucine-221", "are", "critical", "for", "higher", "activity", "of", "mGSTA1", "-", "1", "toward", "(+)-anti-BPDE", "compared", "with", "that", "of", "mGSTA2-2"], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [7, 8]}}
{"token": ["These", "C0086376#ent", "<e1>", "also", "display", "a", "C0221232#ent", "<e2>", "of", "combinations", "of", "known", "signaling", "domains"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0221232", "name": "C0221232#ent", "pos": [6, 7]}}
{"token": ["The", "application", "of", "genetic", "engineering", "techniques", "AJ", "plaque", "C0086376#ent", "<e1>", "has", "recently", "generated", "a", "C0221232#ent", "<e2>", "of", "novel", "observations", ",", "leading", "to", "the", "speculation", "that", "these", "C0086376#ent", "<e1>", "are", "involved", "in", "tumorigenesis", "and", "metastasis", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0221232", "name": "C0221232#ent", "pos": [14, 15]}}
{"token": ["Larger", "C0086376#ent", "<e1>", "can", "also", "exhibit", "a", "C0221232#ent", "<e2>", "of", "sequence", "specific", "fragment", "ions", "in", "favorable", "cases", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0221232", "name": "C0221232#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "the", "prevalence", "and", "natural", "history", "C0026267#ent", "<e1>", "the", "C0024796#ent", "<e2>", "distinct", "from", "C0026267#ent", "<e1>", "associated", "with", "conditions", ",", "including", "idiopathic", "or", "familial", "mitral", "valve", "prolapse"], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0026267", "name": "C0026267#ent", "pos": [7, 8]}}
{"token": ["In", "addition", "to", "the", "autophosphorylation", "of", "C1307407#ent", "<e1>", ",", "32P", "incorporation", "into", "80-kDa", "(", "C3814146#ent", "<e2>", ")", "and", "175-kDa", "(", "pp175", ")", "bands", "was", "observed", "in", "C1307407#ent", "<e1>", "immunoprecipitates", "."], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3814146", "name": "C3814146#ent", "pos": [14, 15]}}
{"token": ["By", "chimeric", "construction", "of", "the", "CCK2", "receptor", "we", "determined", "the", "involvement", "of", "two", "C3274837#ent", "<e1>", "intracellular", "loops", "in", "the", "binding", "of", "C0291985#ent", "<e2>", "and", "SB203580", "."], "h": {"id": "C3274837", "name": "C3274837#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0291985", "name": "C0291985#ent", "pos": [21, 22]}}
{"token": ["A", "direct", "quantitative", "comparison", "of", "anti-writhing", "activity", "was", "made", "between", "orally", "administered", "C0036079#ent", "<e1>", "phenylbutazone", ",", "indometacin", ",", "C0087097#ent", "<e2>", ",", "ketoprofen", "and", "alpha-methyl-4-(2-thienylcarbonyl)benzeneacetic", "acid", "suprofen", ")", "in", "a", "specially", "designed", "experiment", "."], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0087097", "name": "C0087097#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "transfection", "of", "a", "Gab1", "mutant", "lacking", "C1423080#ent", "<e1>", "binding", "sites", "inhibited", "flow-induced", "activation", "of", "Akt", "and", "C1328053#ent", "<e2>", "."], "h": {"id": "C1423080", "name": "C1423080#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [18, 19]}}
{"token": ["This", "C0014442#ent", "<e1>", "inhibition", "results", "in", "a", "clinical", "and", "biochemical", "mimicry", "C1412302#ent", "<e2>", "in", "some", "patients", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412302", "name": "C1412302#ent", "pos": [11, 12]}}
{"token": ["Thoracotomy", "is", "one", "of", "the", "most", "C0030193#ent", "<e1>", "surgical", "procedures", "by", "intense", ",", "acute", ",", "and", "C0150055#ent", "<e2>", "associated", "with", "post-thoracotomy", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0150055", "name": "C0150055#ent", "pos": [16, 17]}}
{"token": ["Both", "silica", "and", "C2697656#ent", "<e1>", "increased", "mRNA", "expression", "in", "these", "cells", "for", "C0033551#ent", "<e2>", "inducible", "nitric", "oxide", "synthase", "tumor", "necrosis", "factor-alpha", "interleukin-1", "alpha"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [12, 13]}}
{"token": ["The", "potent", "FAAH", "inhibitor", "URB597", "reduced", "the", "C2697656#ent", "<e1>", "stimulated", "microglial", "expression", "of", "C0033551#ent", "<e2>", "inducible", "nitric", "oxide", "with", "concomitant", "attenuation", "of", "the", "release", "of", "PGE2", "and", "NO", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [13, 14]}}
{"token": ["By", "improved", "MRI", "techniques", "and", "intravenous", "contrast", "agents", "may", "be", "possible", "to", "visualize", "and", "follow", "the", "C0012634#ent", "<e1>", "ascertain", "more", "of", "the", "pathogenesis", "of", "C0376175#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0376175", "name": "C0376175#ent", "pos": [24, 25]}}
{"token": ["Inhibition", "of", "mitogen-activated", "protein", "kinase", "pharmacological", "inhibitors", "C0164786#ent", "<e1>", "dominant", "negative", "transfections", "prevented", "glucose-", "and", "ET-1-mediated", "C1367472#ent", "<e2>", "and", "ED-B", "C1367472#ent", "<e2>", "expression", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367472", "name": "C1367472#ent", "pos": [16, 17]}}
{"token": ["We", "have", "studied", "possible", "relationships", "between", "eicosapentaenoic", "acid", "EPA", ")", ",", "C0556150#ent", "<e1>", "DHA", ")", "and", "arachidonic", "acid", "AA", ")", "in", "the", "C1417875#ent", "<e2>", "fraction", "and", "biochemical", "markers", "endothelial", "activation", "dysfunction", "."], "h": {"id": "C0556150", "name": "C0556150#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417875", "name": "C1417875#ent", "pos": [22, 23]}}
{"token": ["C1414134#ent", "<e1>", "is", "a", "transcriptional", "regulator", "the", "cooperation", "of", "a", "C1417051#ent", "<e2>", "cysteine-rich", "CXXC", "domains", "and", "a", "transcriptional", "repression", "domain"], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417051", "name": "C1417051#ent", "pos": [10, 11]}}
{"token": ["C1414134#ent", "<e1>", "belongs", "to", "a", "family", "of", "mammalian", "proteins", "share", "a", "C1417051#ent", "<e2>"], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417051", "name": "C1417051#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", "to", "the", "functionally", "related", "proteins", "MeCP2", "and", "C1414134#ent", "<e1>", ",", "the", "repression", "domain", "MBD2b", "overlaps", "with", "the", "C1417051#ent", "<e2>"], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417051", "name": "C1417051#ent", "pos": [19, 20]}}
{"token": ["C3540778#ent", "<e1>", "also", "suppress", "induction", "of", "C0387583#ent", "<e2>", "in", "human", "airway", "smooth", "muscle", "cells", "the", "subsequent", "synthesis", "and", "release", "of", "arachidonic", "acid", "metabolites", ",", "particularly", "prostaglandin", "E2"], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [6, 7]}}
{"token": ["C0937932#ent", "<e1>", "is", "a", "recombinant", "form", "of", "the", "C0041931#ent", "<e2>", "catalyzes", "the", "conversion", "of", "uric", "acid", "the", "more", "soluble", "compound", "allantoin"], "h": {"id": "C0937932", "name": "C0937932#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0041931", "name": "C0041931#ent", "pos": [8, 9]}}
{"token": ["C0937932#ent", "<e1>", ",", "in", "contrast", "with", "the", "non-recombinant", "form", "of", "C0041931#ent", "<e2>", ",", "is", "associated", "with", "low", "incidence", "of", "hypersensitivity", "reactions"], "h": {"id": "C0937932", "name": "C0937932#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0041931", "name": "C0041931#ent", "pos": [10, 11]}}
{"token": ["C0937932#ent", "<e1>", ",", "a", "recombinant", "form", "of", "the", "C0041931#ent", "<e2>", "has", "recently", "become", "available", "and", "may", "further", "reduce", "the", "morbidity", "of", "hyperuricemia", "and", "TLS", "."], "h": {"id": "C0937932", "name": "C0937932#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0041931", "name": "C0041931#ent", "pos": [8, 9]}}
{"token": ["The", "phosphoamino", "acid", "analysis", "that", "C0027103#ent", "<e1>", "a", "serine/threonine", "kinase", "not", "a", "C1421249#ent", "<e2>"], "h": {"id": "C0027103", "name": "C0027103#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [12, 13]}}
{"token": ["C0700483#ent", "<e1>", "is", "a", "widely", "prescribed", "C3536890#ent", "<e2>", "the", "treatment", "of", "HIV", "infection"], "h": {"id": "C0700483", "name": "C0700483#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536890", "name": "C3536890#ent", "pos": [6, 7]}}
{"token": ["Complications", "of", "chronic", "dacryocystitis", "C0009763#ent", "<e1>", ",", "corneal", "ulcer", "acute", "on", "chronic", "dacryocystitis", "C0000833#ent", "<e2>", "fistula", "were", "seen", "in", "25.0", "%", "of", "these", "patients", ";", "53.6", "%", "of", "the", "culture", "samples", "positive", "for", "bacterial", "growth"], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "describe", "a", "mutation", "of", "the", "human", "gene", "endothelin", "3", "EDN3", ")", ",", "homozygously", "present", "in", "a", "patient", "with", "a", "combined", "Waardenburg", "syndrome", "type", "2", "C2346914#ent", "<e1>", ")", "and", "HSCR", "phenotype", "(", "C1848519#ent", "<e2>", "."], "h": {"id": "C2346914", "name": "C2346914#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1848519", "name": "C1848519#ent", "pos": [34, 35]}}
{"token": ["The", "intracellular", "signaling", "events", "by", "the", "physical", "interaction", "MSU", "crystals", "and", "neutrophils", "depend", "on", "the", "activation", "of", "specific", "C1421249#ent", "<e1>", "Src", "and", "C1706351#ent", "<e2>", ",", "in", "particular", ")", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1706351", "name": "C1706351#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "our", "data", "strongly", "supports", "a", "model", "of", "Fc", "epsilon", "RI", "engagement", "leading", "to", "the", "sequential", "activation", "of", "the", "C1421249#ent", "<e1>", "Lyn", "and", "then", "C1706351#ent", "<e2>", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1706351", "name": "C1706351#ent", "pos": [25, 26]}}
{"token": ["Examples", "of", "these", "disorders", "are", "glycogen", "storage", "diseases", "e.g.", "glycogenosis", "type", "II", "III", ")", ",", "lysosomal", "storage", "diseases", "e.g.", "Niemann-Pick", "disease", "C1961835#ent", "<e1>", "I-cell", "disease", "various", "types", "of", "C0023786#ent", "<e2>", ",", "GM1", "gangliosidosis", "galactosialidosis", ",", "carbohydrate-deficient", "glycoprotein", "syndromes", "Sandhoff's", "disease", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0023786", "name": "C0023786#ent", "pos": [28, 29]}}
{"token": ["Bone", "marrow", "transplantation", "to", "be", "effective", "in", "C1961835#ent", "<e1>", "in", "some", "forms", "of", "C0023786#ent", "<e2>", "and", "in", "mild", "forms", "Krabb\u00e9", "disease", "but", "it", "has", "high", "morbidity", "and", "mortality", "that", "limits", "its", "use", "in", "lysosomal", "storage", "disorders"], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023786", "name": "C0023786#ent", "pos": [13, 14]}}
{"token": ["Gene", "localizations", "known", "for", "Emery-Dreifuss", "muscular", "dystrophy", "C1834673#ent", "<e1>", "three", "forms", "of", "'", "limb-girdle'", "muscular", "dystrophy", "severe", "childhood", "autosomal", "recessive", "muscular", "dystrophy", "C0410174#ent", "<e2>"], "h": {"id": "C1834673", "name": "C1834673#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0410174", "name": "C0410174#ent", "pos": [22, 23]}}
{"token": ["Apolipoprotein", "B", "mRNA-editing", "catalytic", "polypeptide-like", "3G", "APOBEC3G", "or", "A3G", "and", "related", "C0010723#ent", "<e1>", "as", "apolipoprotein", "B", "mRNA-editing", "catalytic", "polypeptide-like", "3F", "APOBEC3F", ",", "or", "C1528545#ent", "<e2>", ")", "are", "potent", "inhibitors", "of", "retroviruses", "."], "h": {"id": "C0010723", "name": "C0010723#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528545", "name": "C1528545#ent", "pos": [23, 24]}}
{"token": ["APOBEC3G", "A3G", "and", "related", "C0010723#ent", "<e1>", "such", "as", "C1528545#ent", "<e2>", "(", "A3F", ")", ",", "are", "potent", "inhibitors", "of", "retroviruses", "."], "h": {"id": "C0010723", "name": "C0010723#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528545", "name": "C1528545#ent", "pos": [8, 9]}}
{"token": ["Stimulation", "of", "C1382029#ent", "<e1>", "dependent", "not", "only", "on", "C0220304#ent", "<e2>", "to", "GTP", ",", "but", "also", "on", "the", "CDC25", "and", "IRA", "gene", "products", "which", "appear", "to", "control", "the", "RAS", "GTP-guanosine", "diphosphate", "cycle", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220304", "name": "C0220304#ent", "pos": [8, 9]}}
{"token": ["Human", "C1335621#ent", "<e1>", "2(125", ")", "was", "shown", "to", "be", "directly", "C0026249#ent", "<e2>", "for", "bovine", "and", "porcine", "PBMC", "and", "was", "able", "to", "maintain", "the", "long-term", "growth", "of", "mitogen-activated", "PBMC", "of", "both", "species", "."], "h": {"id": "C1335621", "name": "C1335621#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [10, 11]}}
{"token": ["HPV16", "E6/E7-induced", "immortalization", "was", "accompanied", "by", "reduced", "C0694889#ent", "<e1>", "and", "p53", ",", "but", "increased", "p16", "and", "C1420626#ent", "<e2>", ",", "protein", "expression"], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [16, 17]}}
{"token": ["Potential", "downstream", "effectors", "of", "NO", "include", "the", "second", "messenger", "cyclic", "GMP", "activation", "of", "the", "tumor-suppressor", "genes", "p53", "C0694889#ent", "<e1>", ",", "and", "the", "cyclin-dependent", "kinase", "inhibitor", "C1420626#ent", "<e2>", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [25, 26]}}
{"token": ["Moreover", ",", "retransformation", "by", "C0694889#ent", "<e1>", "of", "LT", "transformed", "epithelial", "cells", "totally", "restored", "C1420626#ent", "<e2>", "expression", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [13, 14]}}
{"token": ["Using", "dominant", "negative", "mutants", ",", "we", "found", "that", "C1420710#ent", "<e1>", "was", "actually", "involved", "in", "endogenous", "C1706383#ent", "<e2>", "expression", "upon", "H(2)O(2", ")", "treatment", "."], "h": {"id": "C1420710", "name": "C1420710#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [15, 16]}}
{"token": ["In", "clonal", "stable", "transformants", "established", "from", "human", "immortalized", "fibroblasts", "by", "transfection", "of", "an", "expression", "vector", "C1420710#ent", "<e1>", ",", "the", "constitutive", "level", "of", "C1706383#ent", "<e2>", "mRNA", "was", "well", "correlated", "with", "that", "of", "C1420710#ent", "<e1>", "."], "h": {"id": "C1420710", "name": "C1420710#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [22, 23]}}
{"token": ["We", "found", "that", ",", "similarly", "to", "thrombin", ",", "selective", "stimulation", "of", "either", "PAR-1", "or", "PAR-4", "by", "specific", "activating", "C0030956#ent", "<e1>", "caused", "accumulation", "of", "GTP-bound", "C1539512#ent", "<e2>", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1539512", "name": "C1539512#ent", "pos": [24, 25]}}
{"token": ["Isochamaejasmin", "also", "induced", "time-dependent", "phosphorylation", "of", "the", "C0600388#ent", "<e1>", "p38", ",", "and", "a", "novel", "C1259877#ent", "<e2>", "PKCdelta", ")", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [14, 15]}}
{"token": ["The", "signaling", "pathways", "the", "anti-apoptotic", "effect", "of", "VP", "involve", "mitogen", "activated", "protein", "MAP", ")", "kinase", "and", "C0600388#ent", "<e1>", "ERK", ")", ",", "Ca(2+)/calmodulin", "dependent", "kinase", "CaMK", ")", "and", "C1259877#ent", "<e2>", "PKC", ")", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [27, 28]}}
{"token": ["Tepoxalin", "suppressed", "murine", "spleen", "cell", "proliferation", "a", "mixed", "lymphocyte", "reaction", "C1705928#ent", "<e1>", ")", "with", "an", "IC50", "of", "1.3", "microM.", "Coadministration", "of", "C0145162#ent", "<e2>", "and", "CsA", "in", "C1705928#ent", "<e1>", "cultures", "showed", "an", "additive", "inhibitory", "effect", "."], "h": {"id": "C1705928", "name": "C1705928#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0145162", "name": "C0145162#ent", "pos": [21, 22]}}
{"token": ["The", "data", "obtained", "from", "this", "study", "suggest", "that", "C1412677#ent", "<e1>", "induced", "by", "PGD2", "and", "C0050218#ent", "<e2>", "may", "play", "a", "role", "in", "the", "metabolic", "regulation", "many", "mammalian", "cells"], "h": {"id": "C1412677", "name": "C1412677#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0050218", "name": "C0050218#ent", "pos": [14, 15]}}
{"token": ["A", "variety", "of", "compounds", "(", "chemosensitizing", "agents", "can", "interfere", "with", "C1418520#ent", "<e1>", "and", "MRP", "function", ";", "such", "C0991617#ent", "<e2>", "may", "improve", "the", "efficacy", "of", "conventional", "therapy", "used", "in", "combination", "with", "such", "regimens", "."], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}}
{"token": ["C0016282#ent", "<e1>", ",", "phenylbutazone", "and", "C0036077#ent", "<e2>", "enhanced", "the", "responses", "to", "SI", "."], "h": {"id": "C0016282", "name": "C0016282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [5, 6]}}
{"token": ["C1428937#ent", "<e1>", "gene", "expression", "analysis", "that", "pS2", "and", "progesterone", "receptor", "C1705324#ent", "<e2>", ")", ",", "genes", "induced", "in", "MCF-7", "cells", "E2", ",", "are", "not", "induced", "in", "the", "ER+", "HeLa", "clones"], "h": {"id": "C1428937", "name": "C1428937#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705324", "name": "C1705324#ent", "pos": [10, 11]}}
{"token": ["This", "review", "discusses", "the", "feasibility", "of", "gene", "therapy", "an", "HVJ-based", "non-viral", "vector", "containing", "the", "VEGF", "or", "C0399440#ent", "<e1>", "gene", "for", "C0007785#ent", "<e2>"], "h": {"id": "C0399440", "name": "C0399440#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [20, 21]}}
{"token": ["It", "may", "cause", "fewer", "C3537004#ent", "<e1>", ",", "antihistaminic", ",", "and", "C0178504#ent", "<e2>", "ADRs", "and", "may", "have", "a", "quicker", "onset", "of", "therapeutic", "action", "existing", "antidepressants", "."], "h": {"id": "C3537004", "name": "C3537004#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0178504", "name": "C0178504#ent", "pos": [10, 11]}}
{"token": ["Sensitised", "by", "the", "observation", "of", "a", "patient", "with", "coexisting", "C3831153#ent", "<e1>", "and", "C1840402#ent", "<e2>", "we", "prospectively", "evaluated", "thyroid", "nodules", "euthyroid", "patients", "with", "C1840402#ent", "<e2>", "by", "thyroid", "scintigraphy"], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [12, 13]}}
{"token": ["Parathyroid", "hormone", "levels", "may", "be", "normal", "or", "suppressed", "if", "hypercalcemia", "is", "due", "to", "C3831153#ent", "<e1>", "alone", ",", "and", "an", "elevated", "parathyroid", "hormone", "level", "suggest", "coexisting", "C1840402#ent", "<e2>", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [25, 26]}}
{"token": ["On", "certain", "conditions", "C3831153#ent", "<e1>", "induces", "a", "hypercalcuria", "leading", "to", "functional", "C1840402#ent", "<e2>", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [11, 12]}}
{"token": ["C0022521#ent", "<e1>", "PCD", ")", "is", "a", "rare", "C0019247#ent", "<e2>", "by", "dysmotility", "to", "immotility", "of", "ciliated", "and", "flagellated", "structures"], "h": {"id": "C0022521", "name": "C0022521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["In", "this", "communication", ",", "we", "demonstrate", "that", "beta-bungarotoxin", "is", "a", "potent", "C0031667#ent", "<e1>", "phosphatide", "2-acyl", "hydrolase", ",", "C0536678#ent", "<e2>", ",", "comparable", "in", "activity", "with", "purified", "phospholipase", "enzymes", "Naja", "naja", "Vipera", "russellii"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [11, 12]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C0536678", "name": "C0536678#ent", "pos": [17, 18]}}
{"token": ["C0007068#ent", "<e1>", "increased", "bacterial", "numbers", "and", "enzyme", "activities", "particularly", "C0005223#ent", "<e2>", "and", "nitrate", "reductase", "added", "to", "the", "purified", "diet", "not", "when", "added", "to", "either", "the", "purified", "diet", "cellulose", "or", "the", "stock", "diet"], "h": {"id": "C0007068", "name": "C0007068#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [9, 10]}}
{"token": ["Pharmacological", "approaches", "enhancing", "GABAergic", "inhibition", "include", "the", "use", "of", "GABA", "C0243192#ent", "<e1>", "(", "or", "prodrugs", ")", ",", "C0002543#ent", "<e2>", "inhibition", ",", "GABA", "uptake", "inhibition", ",", "and", "action", "at", "the", "GABA/benzodiazepine", "allosteric", "site"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002543", "name": "C0002543#ent", "pos": [17, 18]}}
{"token": ["The", "changes", "in", "opioid", "receptors", "Op-R", ")", "caused", "by", "repeated", "administration", "of", "C0030873#ent", "<e1>", "and", "the", "effect", "of", "concomitant", "C0009014#ent", "<e2>", "were", "investigated", "."], "h": {"id": "C0030873", "name": "C0030873#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [19, 20]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "whether", "the", "acidifying", "effect", "of", "C0376261#ent", "<e1>", "is", "neutralized", "by", "the", "alkalinizing", "effect", "hypoalbuminemia", "in", "C0085605#ent", "<e2>"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [23, 24]}}
{"token": ["Mitogen-activated", "protein", "kinases", "MAPKs", ")", "consist", "of", "major", "three", "subfamilies", ",", "C1334481#ent", "<e1>", "ERK", "MAPKs", ")", ",", "the", "C1434639#ent", "<e2>", "JNK", "MAPKs/SAP", "MAPKs", ")", ",", "and", "p38", "MAPKs"], "h": {"id": "C1334481", "name": "C1334481#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1434639", "name": "C1434639#ent", "pos": [18, 19]}}
{"token": ["C0016377#ent", "<e1>", "(", "1", ")", "is", "an", "analgesic", ",", "antipyretic", "and", "C0003211#ent", "<e2>", "is", "practically", "insoluble", "in", "water", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [11, 12]}}
{"token": ["C0395887#ent", "<e1>", "(", "TS", ")", "is", "a", "common", "sequelae", "of", "C0271441#ent", "<e2>", "found", "in", "all", "age", "groups"], "h": {"id": "C0395887", "name": "C0395887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271441", "name": "C0271441#ent", "pos": [10, 11]}}
{"token": ["Observation", "results", "are", "presented", "for", "138", "ears", "with", "various", "disorders", ":", "cholesteatoma", ",", "C0395887#ent", "<e1>", ",", "congenital", "malformation", "ossicular", "dislocation", "otosclerosis", ",", "otitis", "media", "effusion", ",", "C0271441#ent", "<e2>", "etc", "."], "h": {"id": "C0395887", "name": "C0395887#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0271441", "name": "C0271441#ent", "pos": [26, 27]}}
{"token": ["The", "inhibitory", "effects", "of", "the", "anti-apoptotic", "protein", "Bcl-2", "and", "the", "C1516312#ent", "<e1>", "zVAD-fmk", "further", "suggested", "the", "involvement", "of", "apoptosis", "during", "C1704883#ent", "<e2>", "morphogenic", "differentiation"], "h": {"id": "C1516312", "name": "C1516312#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704883", "name": "C1704883#ent", "pos": [20, 21]}}
{"token": ["The", "potency", "of", "C1418873#ent", "<e1>", "was", "significantly", "less", "in", "rats", "treated", "with", "C0035179#ent", "<e2>", "or", "6-hydroxydopamine", "than", "in", "control", "rats", "suggesting", "the", "endogenous", "DA", "is", "required", "for", "the", "action", "of", "C1418873#ent", "<e1>", "."], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [12, 13]}}
{"token": ["Liver", "transplantation", "reserved", "for", "patients", "with", "C0019154#ent", "<e1>", "present", "with", "fulminant", "hepatic", "failure", "end-stage", "liver", "disease", "C0020541#ent", "<e2>", "complications", "."], "h": {"id": "C0019154", "name": "C0019154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020541", "name": "C0020541#ent", "pos": [16, 17]}}
{"token": ["C0392525#ent", "<e1>", "and", "renal", "failure", "secondary", "to", "severe", "C0020500#ent", "<e2>", "were", "complications", "of", "jejunoileal", "bypass", "obesity", ",", "leading", "to", "the", "discontinuation", "of", "this", "procedure", "in", "the", "United", "States", "1980", "."], "h": {"id": "C0392525", "name": "C0392525#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [8, 9]}}
{"token": ["The", "human", "kallikrein", "10", "gene", "[", "C1449006#ent", "<e1>", ",", "also", "known", "as", "normal", "epithelial", "cell-specific", "1", "gene", "C1416670#ent", "<e2>", ")", "]", "is", "a", "member", "of", "the", "human", "kallikrein", "gene", "family"], "h": {"id": "C1449006", "name": "C1449006#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416670", "name": "C1416670#ent", "pos": [17, 18]}}
{"token": ["C1449006#ent", "<e1>", "KLK8", ")", "is", "a", "member", "of", "the", "human", "C1416670#ent", "<e2>", "serine", "proteases", "and", "its", "protein", ",", "hK8", ",", "has", "recently", "been", "suggested", "to", "serve", "as", "a", "new", "ovarian", "cancer", "marker", "."], "h": {"id": "C1449006", "name": "C1449006#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416670", "name": "C1416670#ent", "pos": [10, 11]}}
{"token": ["Different", "concentrations", "of", "magnesium", "and", "cobalt", "activated", "the", "enzyme", "while", "C3541971#ent", "<e1>", ",", "copper", ",", "arsenate", ",", "C0144544#ent", "<e2>", "and", "p-mercuribenzoate", "brought", "about", "inhibition", "."], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0144544", "name": "C0144544#ent", "pos": [17, 18]}}
{"token": ["The", "fusion", "transcripts", "code", "for", "putative", "C1833996#ent", "<e1>", "the", "pointed", "domain", "of", "ETV6", "and", "almost", "the", "complete", "C0812381#ent", "<e2>", "including", "the", "SH2", ",", "SH3", "domains", "the", "protein", "tyrosine", "kinase", "domain", "PTK", ")", "."], "h": {"id": "C1833996", "name": "C1833996#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0812381", "name": "C0812381#ent", "pos": [17, 18]}}
{"token": ["One", "patient", "with", "C0040015#ent", "<e1>", "three", "with", "Type", "III", "von", "Willebrand's", "disease", "successfully", "treated", "with", "C0534191#ent", "<e2>", "."], "h": {"id": "C0040015", "name": "C0040015#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0534191", "name": "C0534191#ent", "pos": [15, 16]}}
{"token": ["Comparison", "of", "the", "deduced", "amino", "acid", "sequences", "tfdB", "and", "C0071376#ent", "<e1>", "revealed", "highly", "conserved", "regions", "in", "the", "protein", "products", "these", "C1417679#ent", "<e2>", "."], "h": {"id": "C0071376", "name": "C0071376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["The", "inferior", "colliculus", "IC", ")", "is", "strongly", "implicated", "in", "seizure", "initiation", "in", "a", "genetic", "form", "C0036572#ent", "<e1>", "C0796126#ent", "<e2>", ")", "and", "in", "C0796126#ent", "<e2>", "observed", "during", "ethanol", "withdrawal", "(", "ETX", ")", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [17, 18]}}
{"token": ["Sound", "stimulation", "Imi/Cil-injected", "rats", "elicited", "typical", "C0036572#ent", "<e1>", "which", "were", "induced", "during", "five", "C0796126#ent", "<e2>", "tests", "(", "75", "minutes", "postinjection", ")", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [13, 14]}}
{"token": ["After", "an", "C0036572#ent", "<e1>", "the", "threshold", "for", "bicuculline-induced", "seizures", "in", "C0796126#ent", "<e2>", "rats", "also", "rose", "significantly", "but", "declined", "rapidly", "after", "having", "reached", "a", "maximum", "at", "15", "min", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [10, 11]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "investigate", "the", "preventive", "effect", "(-)epigallocatechin", "gallate", "EGCG", ")", "on", "heart", "weight", "cardiac", "marker", "C3540790#ent", "<e1>", ",", "membrane-bound", "ATPases", "electrolytes", "in", "C0282211#ent", "<e2>", "(ISO)-induced", "myocardial", "infarcted", "MI", ")", "Wistar", "rats"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [26, 27]}}
{"token": ["The", "LTD4", "antagonist", "C0064490#ent", "<e1>", "did", "not", "inhibit", "the", "rHuC5a-induced", "bronchoconstriction", "whereas", "the", "cyclo-oxygenase", "inhibitor", "C0021246#ent", "<e2>", "did", "."], "h": {"id": "C0064490", "name": "C0064490#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [15, 16]}}
{"token": ["Human", "defensin", "HD", ")", "5", "and", "C1333895#ent", "<e1>", ",", "both", "Paneth", "cell", "alpha-defensins", "contribute", "to", "the", "antimicrobial", "barrier", "C0178238#ent", "<e2>"], "h": {"id": "C1333895", "name": "C1333895#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0178238", "name": "C0178238#ent", "pos": [18, 19]}}
{"token": ["However", ",", "the", "effect", "of", "FGF", "is", "not", "mediated", "by", "C1956039#ent", "<e1>", "TPA-sensitive", "isoforms", "of", "protein", "kinase-C", "p70S6K", "C3540564#ent", "<e2>", "(", "all", "of", "which", "phosphorylate", "CREB", "at", "Ser133", "in", "vitro", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540564", "name": "C3540564#ent", "pos": [18, 19]}}
{"token": ["In", "the", "first", "presentation", ",", "Dorit", "Ron", "presented", "data", "showing", "how", "activation", "of", "Fyn", "or", "C0282625#ent", "<e1>", "regulated", "the", "cell", "surface", "expression", "and", "activity", "of", "NR2A", "and", "C1415300#ent", "<e2>", "containing", "NMDA", "receptors"], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415300", "name": "C1415300#ent", "pos": [27, 28]}}
{"token": ["The", "C2987634#ent", "<e1>", "effect", "of", "C0004855#ent", "<e2>", "1", "microM", ")", "on", "Ca2", "+", "channels", "was", "elicited", "to", "the", "same", "extent", "at", "either", "HP", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004855", "name": "C0004855#ent", "pos": [5, 6]}}
{"token": ["Then", "cell", "proliferation", ",", "intracellular", "Ca(2+)", "concentration", "and", "extracellular", "signal-regulated", "kinase", "1/2", "ERK1/2", ")", "activity", "were", "assessed", "after", "treatment", "with", "EGF", ",", "a", "calcium", "channel", "blocker", "C2987634#ent", "<e1>", ",", "verapamil", "and", "C0004855#ent", "<e2>"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0004855", "name": "C0004855#ent", "pos": [31, 32]}}
{"token": ["Therefore", ",", "using", "a", "colitis-induced", "tumorigenesis", "rat", "model", ",", "we", "investigated", "the", "effects", "of", "C0059865#ent", "<e1>", ",", "a", "selective", "C1257954#ent", "<e2>", "on", "tumorigenesis", "."], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1257954", "name": "C1257954#ent", "pos": [19, 20]}}
{"token": ["The", "interaction", "of", "bovine", "liver", "rhodanese", "(", "thiosulfate", ":", "C0038790#ent", "<e1>", "EC", "2.8.1.1", ")", "with", "the", "acceptor", "substrates", ",", "C0012789#ent", "<e2>", "or", "cyanide", ",", "was", "studied", "."], "h": {"id": "C0038790", "name": "C0038790#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [19, 20]}}
{"token": ["The", "main", "fatty", "acids", "in", "polar", "lipids", "C0017860#ent", "<e1>", "were", "palmitate", ",", "palmitoleate", ",", "eicosaenoate", ",", "arachidonate", "and", "C1370123#ent", "<e2>", ",", "while", "palmitate", "and", "palmitoleate", "predominated", "in", "C0017860#ent", "<e1>", "."], "h": {"id": "C1370123", "name": "C1370123#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [7, 8]}}
{"token": ["Further", ",", "the", "effects", "of", "pretreatment", "with", "dopamine", "D1-like", "receptor", "antagonist", "C0080138#ent", "<e1>", ")", "were", "examined", "to", "elucidate", "the", "mechanisms", "associated", "with", "C1420645#ent", "<e2>", "reward", "."], "h": {"id": "C0080138", "name": "C0080138#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420645", "name": "C1420645#ent", "pos": [22, 23]}}
{"token": ["C0004623#ent", "<e1>", "pyoderma", ",", "mycobacterial", "infections", "diphtheria", ",", "and", "C0003175#ent", "<e2>", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0003175", "name": "C0003175#ent", "pos": [9, 10]}}
{"token": ["Some", "C0004623#ent", "<e1>", "eg", ",", "plague", "and", "C0003175#ent", "<e2>", ",", "are", "associated", "with", "mortality", "rates", "and", "are", "of", "potential", "use", "in", "bioterrorism", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0003175", "name": "C0003175#ent", "pos": [7, 8]}}
{"token": ["5-Formyltetrahydrofolate", "or", "C2939773#ent", "<e1>", "added", "to", "fibroblasts", "not", "exposed", "to", "C1417487#ent", "<e2>", "reduced", "the", "Hcy", "export", "rate", ",", "whereas", "the", "export", "from", "the", "lymphoma", "cells", "not", "affected", "."], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [10, 11]}}
{"token": ["Likewise", ",", "an", "antiserum", "against", "the", "C0017801#ent", "<e1>", "E.", "coli", "precipitated", "the", "C0040676#ent", "<e2>", "and", "both", "synthetic", "activities", "similar", "titers", "."], "h": {"id": "C0017801", "name": "C0017801#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040676", "name": "C0040676#ent", "pos": [12, 13]}}
{"token": ["In", "C0014060#ent", "<e1>", ",", "a", "high", "level", "may", "suggest", "additional", "C0004623#ent", "<e2>"], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [10, 11]}}
{"token": ["A", "72-year-old", "woman", "with", "diabetes", "mellitus", "hypertension", "and", "C0242339#ent", "<e1>", "presented", "with", "severe", "chest", "pain", "four", "hours", "C2926735#ent", "<e2>", "."], "h": {"id": "C0242339", "name": "C0242339#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "sequential", "addition", "of", "the", "same", "C0031671#ent", "<e1>", "reduced", "the", "activity", "of", "4-ene", "steroid", "5", "C0055533#ent", "<e2>", "to", "approx", "40", "%", "of", "the", "control", "level"], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0055533", "name": "C0055533#ent", "pos": [17, 18]}}
{"token": ["Consequently", ",", "it", "was", "not", "possible", "to", "test", "for", "cooperative", "effects", "C0031671#ent", "<e1>", "on", "the", "C0055533#ent", "<e2>"], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0055533", "name": "C0055533#ent", "pos": [15, 16]}}
{"token": ["Strains", "which", "contain", "a", "fusion", "between", "a", "C0079429#ent", "<e1>", "specifying", "a", "C1333199#ent", "<e2>", "lacZ", "exhibit", "novel", "phenotypes", "that", "can", "be", "exploited", "to", "obtain", "export-defective", "mutations", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333199", "name": "C1333199#ent", "pos": [11, 12]}}
{"token": ["We", "identified", "a", "Dissociation", "(", "Ds", ")", "transposon-inserted", "Arabidopsis", "mutant", "of", "a", "C0079429#ent", "<e1>", "(", "AtRPS13A", ")", "homologous", "to", "C1333199#ent", "<e2>", "RP", ")", "S13", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333199", "name": "C1333199#ent", "pos": [19, 20]}}
{"token": ["Increased", "C0338271#ent", "<e1>", "production", "under", "serum", "or", "TNF-alpha", "stimulation", "suggests", "that", "C0268731#ent", "<e2>", "C0338271#ent", "<e1>", "may", "contribute", "to", "the", "development", "of", "glomerular", "diseases"], "h": {"id": "C0338271", "name": "C0338271#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [11, 12]}}
{"token": ["This", "was", "an", "open-label", "study", "6", "patients", "with", "C1720860#ent", "<e1>", "receiving", "maximal", "doses", "oral", "C0935929#ent", "<e2>", "and", "lipid-lowering", "medications", "at", "baseline", "."], "h": {"id": "C1720860", "name": "C1720860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [14, 15]}}
{"token": ["We", "performed", "simultaneous", "catheter", "mapping", "right", "and", "left", "atrial", "regions", "at", "onset", "and", "during", "sustenance", "of", "spontaneous", "atrial", "fibrillation", "C0004238#ent", "<e1>", ")", "in", "patients", "with", "ischemic", "and/or", "C0152105#ent", "<e2>"], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0152105", "name": "C0152105#ent", "pos": [27, 28]}}
{"token": ["We", "have", "performed", "catheter", "mapping", "in", "right", "and", "left", "atrial", "sites", "at", "onset", "and", "during", "sustained", "pacing-induced", "and", "spontaneous", "C0004238#ent", "<e1>", "in", "patients", "with", "ischemic", "and/or", "C0152105#ent", "<e2>"], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0152105", "name": "C0152105#ent", "pos": [26, 27]}}
{"token": ["The", "C3273276#ent", "<e1>", ",", "st", "was", "significantly", "higher", "in", "C1332766#ent", "<e2>", "rats", "than", "both", "H2", "and", "controls", "."], "h": {"id": "C3273276", "name": "C3273276#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332766", "name": "C1332766#ent", "pos": [9, 10]}}
{"token": ["NaSCN", "and", "C0020923#ent", "<e1>", "mimicked", "the", "effect", "of", "omeprazole", "on", "acid", "secretion", "but", "C0030909#ent", "<e2>", "release", "was", "only", "stimulated", "with", "10(-2", ")", "M", "imidazole", "."], "h": {"id": "C0020923", "name": "C0020923#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030909", "name": "C0030909#ent", "pos": [13, 14]}}
{"token": ["The", "rate", "and", "extent", "of", "the", "agonist-dependent", "phosphorylation", "of", "beta", "2-adrenergic", "receptors", "rhodopsin", "by", "beta-adrenergic", "receptor", "kinase", "C0812237#ent", "<e1>", "are", "markedly", "enhanced", "on", "addition", "of", "C1415155#ent", "<e2>"], "h": {"id": "C0812237", "name": "C0812237#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415155", "name": "C1415155#ent", "pos": [25, 26]}}
{"token": ["The", "phosphorylation", "by", "C0812237#ent", "<e1>", "also", "found", "to", "be", "stimulated", "by", "C1415155#ent", "<e2>"], "h": {"id": "C0812237", "name": "C0812237#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415155", "name": "C1415155#ent", "pos": [11, 12]}}
{"token": ["We", "sought", "to", "determine", "the", "prevalence", "of", "C0151947#ent", "<e1>", "patients", "with", "C0013743#ent", "<e2>", "to", "identify", "individuals", "at", "highest", "risk", "."], "h": {"id": "C0151947", "name": "C0151947#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013743", "name": "C0013743#ent", "pos": [11, 12]}}
{"token": ["To", "evaluate", "the", "validity", "of", "self-assessment", "of", "sexual", "maturity", "status", "SMS", ")", "in", "children", "with", "C0156147#ent", "<e1>", "CD", ")", ",", "a", "C0679381#ent", "<e2>", "often", "affects", "growth", "and", "development", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0679381", "name": "C0679381#ent", "pos": [21, 22]}}
{"token": ["C0034880#ent", "<e1>", "and", "phonophobia", "are", "common", ",", "debilitating", "symptoms", "in", "C0175702#ent", "<e2>", "WS", ")", ",", "yet", "little", "is", "known", "about", "their", "underlying", "audiologic", "and", "neurologic", "processes"], "h": {"id": "C0034880", "name": "C0034880#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [10, 11]}}
{"token": ["Parental", "questionnaires", "used", "to", "determine", "the", "prevalence", "of", "C0034880#ent", "<e1>", "and", "otitis", "media", "individuals", "with", "C0175702#ent", "<e2>"], "h": {"id": "C0034880", "name": "C0034880#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0175702", "name": "C0175702#ent", "pos": [15, 16]}}
{"token": ["T-cell", "depletion", "in", "vivo", "adoptive", "serum", "transfer", "that", "protein-rich", "antigens", "induced", "T-cell", "dependent", "delayed", "hypersensitivity", "reactions", "whereas", "C2697656#ent", "<e1>", "only", "elicited", "C0003907#ent", "<e2>"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003907", "name": "C0003907#ent", "pos": [21, 22]}}
{"token": ["Epidemiological", ",", "clinical", "and", "serological", "data", "uranium", "miners", "symptoms", "of", "C0009782#ent", "<e1>", "CTD", ")", "were", "collected", "during", "the", "control", "examinations", "C0028797#ent", "<e2>", "1975", "."], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0028797", "name": "C0028797#ent", "pos": [20, 21]}}
{"token": ["The", "C0080054#ent", "<e1>", "by", "the", "C1332721#ent", "<e2>", "a", "key", "component", "of", "the", "eukaryotic", "cell", "cycle", "for", "the", "G1-", "to", "S-phase", "transition", "entry", "into", "mitosis", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332721", "name": "C1332721#ent", "pos": [5, 6]}}
{"token": ["On", "the", "other", "hand", ",", "there", "was", "little", "change", "in", "the", "C1416587#ent", "<e1>", "AMPA", "component", "between", "C1425980#ent", "<e2>", "and", "P24", "."], "h": {"id": "C1416587", "name": "C1416587#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1425980", "name": "C1425980#ent", "pos": [16, 17]}}
{"token": ["Newborns", "with", "clinically", "evident", "forms", "of", "C0020758#ent", "<e1>", "generally", "classified", "as", "\"", "C0079154#ent", "<e2>", "in", "view", "of", "the", "particular", "appearance", "of", "their", "skin", "that", "looks", "rather", "like", "a", "membrane", "of", "dried", "cellophane"], "h": {"id": "C0020758", "name": "C0020758#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079154", "name": "C0079154#ent", "pos": [12, 13]}}
{"token": ["A", "negative", "urine", "test", "C0119860#ent", "<e1>", "extreme", "stiffness", "of", "skin", "indicated", "a", "C2931894#ent", "<e2>", "hitherto", "unknown", "in", "animals", "."], "h": {"id": "C0119860", "name": "C0119860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2931894", "name": "C2931894#ent", "pos": [12, 13]}}
{"token": ["The", "nonspecific", "C0242947#ent", "<e1>", "carbachol", "increased", "C1332804#ent", "<e2>", "secretion", "only", "in", "the", "presence", "of", "an", "M2", "receptor", "antagonist", "suggesting", "that", "activation", "of", "M2", "receptors", "suppresses", "C1332804#ent", "<e2>", "formation", "."], "h": {"id": "C0242947", "name": "C0242947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [6, 7]}}
{"token": ["The", "magnitude", "of", "the", "C0027203#ent", "<e1>", "suppression", "by", "the", "C0991617#ent", "<e2>", "varied", "with", "the", "tumor", "line"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [9, 10]}}
{"token": ["The", "sequential", "loss", "in", "C1418881#ent", "<e1>", "was", "not", "due", "to", "C1710463#ent", "<e2>", "there", "was", "no", "change", "in", "RNA", "levels", "for", "any", "of", "the", "genes", "tested", "."], "h": {"id": "C1418881", "name": "C1418881#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [10, 11]}}
{"token": ["In", "the", "current", "study", ",", "downstream", "effectors", "of", "p38", "MAP", "kinase", "sought", "by", "first", "screening", "for", "proteins", "phosphorylated", "after", "C1366557#ent", "<e1>", "treatment", ",", "only", "in", "the", "absence", "of", "C3494348#ent", "<e2>", "p38", "MAP", "kinase"], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [28, 29]}}
{"token": ["In", "contrast", ",", "the", "beta", "block", "two", "major", "duplications", "containing", "the", "genes", "HLA-B", "and", "C1415562#ent", "<e1>", ",", "and", "MICA", "(", "C4284187#ent", "<e2>", ")", "and", "MICB", "(", "PERB11.2", ")", "."], "h": {"id": "C1415562", "name": "C1415562#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4284187", "name": "C4284187#ent", "pos": [20, 21]}}
{"token": ["It", "is", "suggested", "that", "the", "amber", "mutation", "question", "may", "be", "in", "a", "gene", "system", "encoding", "a", "transcriptional", "activator", "the", "C0029899#ent", "<e1>", "govern", "the", "C0132555#ent", "<e2>", "."], "h": {"id": "C0029899", "name": "C0029899#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [23, 24]}}
{"token": ["Low", "doses", "directly", "acting", "C2936799#ent", "<e1>", "progabide", ",", "4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin--3", "-", "01", ")", "or", "a", "neuronal", "C0597607#ent", "<e2>", "SKF", "100330-A", ")", "potentiate", "apomorphine-induced", "turning", "."], "h": {"id": "C2936799", "name": "C2936799#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597607", "name": "C0597607#ent", "pos": [15, 16]}}
{"token": ["The", "objective", "was", "to", "analyse", "whether", "the", "activity", "of", "the", "cytochrome", "P450", "C1142644#ent", "<e1>", "is", "altered", "by", "disease", "activity", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [19, 20]}}
{"token": ["Acini", "were", "isolated", "by", "C0162745#ent", "<e1>", "incubated", "with", "the", "alpha(1)-adrenergic", "agonist", "phenylephrine", "or", "the", "cholinergic", "C0243192#ent", "<e2>", "carbachol", ",", "and", "activation", "of", "MAPK", "and", "protein", "secretion", "then", "measured", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [15, 16]}}
{"token": ["All", "antiestrogens", "studied", "were", "C0243192#ent", "<e1>", "in", "co-transfections", "of", "a", "C0162745#ent", "<e2>", "ERbeta", ",", "but", "tamoxifen", "alone", "was", "C0243192#ent", "<e1>", "with", "ERalpha", "in", "(", "uterine", ")", "HEC-1-A", "cells", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}}
{"token": ["We", "have", "used", "this", "method", "for", "analysis", "of", "therapeutic", "and", "overdose", "concentrations", "of", "C1564434#ent", "<e1>", ",", "and", "to", "investigate", "the", "stability", "of", "the", "C0013227#ent", "<e2>", "in", "blood", "."], "h": {"id": "C1564434", "name": "C1564434#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [23, 24]}}
{"token": ["The", "plasma", "concentrations", "of", "C1564434#ent", "<e1>", "were", "determined", "by", "gas", "chromatography", "compared", "with", "the", "clinical", "effects", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C1564434", "name": "C1564434#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["We", "have", "employed", "a", "human", "C1442738#ent", "<e1>", "cDNA", "probe", "study", "the", "expression", "of", "this", "C0079429#ent", "<e2>", "at", "the", "mRNA", "level", "in", "BALB/c3T3", "mouse", "cells", "different", "growth", "conditions", "in", "exponentially", "growing", "HeLa", "cells", "the", "cell", "division", "cycle"], "h": {"id": "C1442738", "name": "C1442738#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "unexpectedly", ",", "hypertriglyceridemia", "alone", "in", "the", "absence", "of", "CETP", "was", "also", "found", "to", "cause", "lower", "HDL-C", "and", "C0052179#ent", "<e1>", "levels", "primarily", "by", "decreasing", "C0266427#ent", "<e2>", "."], "h": {"id": "C0052179", "name": "C0052179#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0266427", "name": "C0266427#ent", "pos": [25, 26]}}
{"token": ["Gaucher", "disease", "an", "inherited", "C0025517#ent", "<e1>", "by", "defective", "activity", "of", "the", "lysosomal", "enzyme", "C1414998#ent", "<e2>", ",", "resulting", "in", "accumulation", "of", "the", "lipids", ",", "glucosylceramide", "(", "GlcCer", ")", ",", "and", "glucosylsphingosine", "(", "GlcSph", ")", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414998", "name": "C1414998#ent", "pos": [13, 14]}}
{"token": ["We", "have", "used", "microelectrode", "recordings", "nerve", "cell", "impulse", "frequencies", "and", "in", "vivo", "recordings", "of", "C0026454#ent", "<e1>", "release", "to", "evaluate", "effects", "of", "arylpiperazine", "5-HT1A", "anxiolytics", ",", "C0006462#ent", "<e2>", "and", "ipsapirone", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006462", "name": "C0006462#ent", "pos": [25, 26]}}
{"token": ["The", "plaque", "forming", "cell", "(", "C3889643#ent", "<e1>", ")", "response", "of", "patients", "with", "C0003872#ent", "<e2>", "uncomplicated", "psoriasis", "was", "not", "different", "from", "those", "of", "the", "normal", "controls", "of", "patients", "with", "osteoarthritis", "."], "h": {"id": "C3889643", "name": "C3889643#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [12, 13]}}
{"token": ["Promoter", "properties", "analyzed", "for", "the", "convergently-overlapped", "E.", "coli", "genes", "coding", "for", "the", "C1418729#ent", "<e1>", "dnaQ", ")", "and", "the", "ribonuclease", "H", "C3539762#ent", "<e2>", ")", "."], "h": {"id": "C1418729", "name": "C1418729#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539762", "name": "C3539762#ent", "pos": [20, 21]}}
{"token": ["Our", "results", "indicated", "that", "despite", "continuation", "of", "galactose", "feeding", "C2348243#ent", "<e1>", "Sorbinil", ",", "a", "C0020208#ent", "<e2>", ",", "arrested", "further", "progression", "and", "promoted", "a", "reparative", "process", "."], "h": {"id": "C2348243", "name": "C2348243#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020208", "name": "C0020208#ent", "pos": [14, 15]}}
{"token": ["The", "pedf", "gene", "is", "closely", "linked", "to", "an", "autosomal-dominant", "locus", "C0035334#ent", "<e1>", "suggesting", "that", "C3540534#ent", "<e2>", "could", "be", "a", "survival", "factor", "photoreceptors", "."], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540534", "name": "C3540534#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "results", "raise", "the", "possibility", "that", "this", "C0694890#ent", "<e1>", "a", "new", "C1333196#ent", "<e2>", "specifically", "regulating", "thrombocytopoiesis", "."], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "we", "examined", "the", "relative", "affinities", "of", "p37AUF1", "and", "HuR", "for", "a", "diverse", "set", "ofARE-containing", "mRNAs", "encoding", "beta-adrenergic", "receptors", "a", "C0694890#ent", "<e1>", ",", "and", "a", "C1333196#ent", "<e2>", "."], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [26, 27]}}
{"token": ["Measurement", "of", "C1415042#ent", "<e1>", "S100B", "levels", "showed", "a", "significant", "increase", "in", "the", "C1420709#ent", "<e2>", "mice", ",", "consistent", "with", "glial", "activation", "neuroinflammation", "in", "response", "to", "injury", "."], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [12, 13]}}
{"token": ["The", "inferior", "olivary", "nucleus", "ION", ")", "from", "nine", "patients", "with", "multiple", "system", "atrophy", "examined", "with", "antibodies", "against", "alpha-synuclein", ",", "ubiquitin", ",", "synaptophysin", ",", "C1415042#ent", "<e1>", "the", "Golgi", "apparatus", "network", "(", "C1420709#ent", "<e2>", ")", ",", "and", "microglia/macrophages", "."], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [30, 31]}}
{"token": ["Although", "lymphocytes", "from", "patients", "with", "primary", "and", "C0149985#ent", "<e1>", "normally", "to", "C0030779#ent", "<e2>", "and", "PWM", ",", "their", "response", "to", "SLO", "was", "suppressed", "and", "they", "failed", "to", "show", "significant", "stimulation", "by", "treponemes", "."], "h": {"id": "C0149985", "name": "C0149985#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [11, 12]}}
{"token": ["Spontaneously", "hypertensive", "rats", "treated", "with", "high", "dose", "Cyclosporine", "A", "a", "similar", "decrease", "of", "beta-subunit", "antigen", "in", "the", "renal", "medulla", "decreased", "levels", "of", "two", "subunit", "antigens", "C1537985#ent", "<e1>", "but", "had", "increased", "medullary", "levels", "the", "C0887847#ent", "<e2>", "the", "F1-ATPase", "."], "h": {"id": "C1537985", "name": "C1537985#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0887847", "name": "C0887847#ent", "pos": [33, 34]}}
{"token": ["In", "contrast", ",", "IFN-gamma", ",", "which", "activates", "Stat1", "but", "not", "C1367307#ent", "<e1>", ",", "induces", "expression", "of", "C1420610#ent", "<e2>", "but", "not", "IL-12Rbeta2", "in", "naive", "T", "cells"], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [16, 17]}}
{"token": ["By", "electron", "microscopy", "the", "development", "of", "microvilli", "in", "C0242852#ent", "<e1>", "was", "found", "to", "occur", "coincidentally", "with", "C0028978#ent", "<e2>", "expression", "in", "vitro"], "h": {"id": "C0242852", "name": "C0242852#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [16, 17]}}
{"token": ["C1706544#ent", "<e1>", ",", "but", "not", "C1705281#ent", "<e2>", ",", "coimmunoprecipitated", "with", "ezrin", "in", "NCI-H292", "cells", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [5, 6]}}
{"token": ["We", "report", "a", "case", "of", "a", "60-year-old", "man", "with", "an", "C3537142#ent", "<e1>", "drug-resistant", "atrial", "tachycardia", "AT", ")", "mimicking", "C4049859#ent", "<e2>", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [18, 19]}}
{"token": ["At", "the", "time", "of", "diagnosis", ",", "tumor", "C0011522#ent", "<e1>", "were", "PCR-amplified", "using", "sense", "primer", "for", "the", "heavy", "chain", "variable", "region", "C1420224#ent", "<e2>", ")", "and", "antisense", "primer", "for", "the", "heavy", "chain", "joining", "region", "JH", ")", "of", "the", "IgH", "gene"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420224", "name": "C1420224#ent", "pos": [20, 21]}}
{"token": ["The", "complementary", "C0011522#ent", "<e1>", "encoding", "the", "variable", "regions", "of", "the", "heavy", "chain", "C1420224#ent", "<e2>", ")", "and", "light", "chain", "VL", ")", "were", "connected", "by", "a", "(Gly4Ser)3", "linker", ",", "using", "an", "assembly", "polymerase", "chain", "reaction"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420224", "name": "C1420224#ent", "pos": [12, 13]}}
{"token": ["C0014442#ent", "<e1>", "are", "suggested", "to", "be", "specific", "to", "slow-muscle", "longitudinal", "sarcoplasmic", "reticulum", "the", "C2698405#ent", "<e2>", "cytochrome", "b(5)", "reductase", "mol.wt", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2698405", "name": "C2698405#ent", "pos": [13, 14]}}
{"token": ["C1366459#ent", "<e1>", "was", "also", "degraded", "in", "cells", "treated", "with", "C0075193#ent", "<e2>", "or", "etoposide", ",", "suggesting", "that", "degradation", "of", "focal", "adhesion", "proteins", "a", "characteristic", "feature", "of", "apoptosis", "."], "h": {"id": "C1366459", "name": "C1366459#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [9, 10]}}
{"token": ["To", "determine", "quantitatively", "the", "discriminant", "and", "characteristics", "of", "cor", "pulmonale", "201T1", "myocardial", "perfusion", "single", "photon", "emission", "computed", "tomography", "SPECT", ")", "was", "performed", "in", "16", "patients", "with", "chronic", "obstructive", "pulmonary", "disease", "C1647218#ent", "<e1>", ")", "and", "seven", "with", "C0877013#ent", "<e2>", "RPD", ")", "."], "h": {"id": "C1647218", "name": "C1647218#ent", "pos": [30, 31]}, "relation": "NA", "t": {"id": "C0877013", "name": "C0877013#ent", "pos": [36, 37]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "ND4L", "and", "C1537994#ent", "<e2>", "are", "identified", "as", "contiguous", "C1417679#ent", "<e1>", "with", "overlapping", "termination", "and", "initiation", "codons", "."], "h": {"id": "C1537994", "name": "C1537994#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}}
{"token": ["Mutations", "were", "identified", "in", "genes", "encoding", "C1419655#ent", "<e1>", "23S", "rRNA", "positions", "proximal", "to", "the", "C0058361#ent", "<e2>"], "h": {"id": "C1419655", "name": "C1419655#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0058361", "name": "C0058361#ent", "pos": [14, 15]}}
{"token": ["The", "clinical", "outcome", "tamoxifen-treated", "breast", "cancer", "patients", "may", "be", "influenced", "by", "the", "activity", "of", "cytochrome", "P450", "C3540790#ent", "<e1>", "that", "catalyze", "the", "formation", "of", "antiestrogenic", "metabolites", "endoxifen", "and", "C2347999#ent", "<e2>", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2347999", "name": "C2347999#ent", "pos": [27, 28]}}
{"token": ["Both", "antagonists", "of", "histamine", "H(2)-receptors", "(", "roxatidine", "and", "C0600832#ent", "<e1>", ")", "and", "H(1)-receptors", "(", "epinastine", "and", "C0041090#ent", "<e2>", ")", "significantly", "inhibited", "lesion", "formation", "at", "doses", "that", "did", "not", "inhibit", "acid", "secretion"], "h": {"id": "C0600832", "name": "C0600832#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041090", "name": "C0041090#ent", "pos": [16, 17]}}
{"token": ["Contraction", "induced", "by", "C0010583#ent", "<e1>", "was", "dependent", "on", "the", "C1413043#ent", "<e2>", "+", "concentration", "in", "the", "external", "solution"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "the", "release", "of", "C0010583#ent", "<e1>", "CNS", "mitochondria", "induced", "by", "C1413043#ent", "<e2>", "+", "in", "vitro", "well", "as", "in", "situ", "the", "mPT", "and", "appeared", "to", "require", "the", "rupture", "of", "the", "outer", "membrane"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [11, 12]}}
{"token": ["The", "vitreal", "ERG", "(", "VERG", ")", "from", "the", "C0035305#ent", "<e1>", "simultaneously", "recorded", "between", "the", "shorter", "C1823282#ent", "<e2>", "and", "a", "scleral", "electrode"], "h": {"id": "C0035305", "name": "C0035305#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1823282", "name": "C1823282#ent", "pos": [15, 16]}}
{"token": ["In", "18", "of", "these", ",", "there", "was", "associated", "C1720797#ent", "<e1>", "three", "cases", "acute", "prostatitis", "in", "two", "cases", "C0018204#ent", "<e2>"], "h": {"id": "C1720797", "name": "C1720797#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018204", "name": "C0018204#ent", "pos": [17, 18]}}
{"token": ["The", "identified", "substrate", "specificities", "of", "these", "C0031727#ent", "<e1>", ",", "together", "with", "known", "crystal", "structures", "protein", "kinase", "A", "C0108855#ent", "<e2>", ",", "Erk2", ",", "twitchin", ",", "and", "casein", "kinase", "I", "provide", "a", "structural", "basis", "for", "the", "substrate", "recognition", "protein", "Ser/Thr", "kinases"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0108855", "name": "C0108855#ent", "pos": [17, 18]}}
{"token": ["Nevertheless", ",", "high", "levels", "of", "C0265219#ent", "<e1>", "activity", "can", "be", "found", "in", "sera", "from", "patients", "with", "C0243026#ent", "<e2>", "and", "septic", "shock"], "h": {"id": "C0265219", "name": "C0265219#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [16, 17]}}
{"token": ["C0002644#ent", "<e1>", "(", "Demolox", ";", "Lederle", ")", ",", "an", "C0003289#ent", "<e2>", "was", "administered", "to", "24", "patients", "suffering", "from", "pathological", "depression", "an", "open", "uncontrolled", "single-blind", "study"], "h": {"id": "C0002644", "name": "C0002644#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [9, 10]}}
{"token": ["Here", ",", "we", "review", "these", "different", "modes", "of", "C4285220#ent", "<e1>", "expression", "and", "provide", "a", "model", "for", "transcriptional", "regulation", "C4285220#ent", "<e1>", "C0017337#ent", "<e1>", "."], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["This", "persisted", "despite", "symptomatic", "treatment", "with", "anti-proteinuric", "agents", "(", "C0014027#ent", "<e1>", "20", "mg/day", "and", "irbesartan", "75", "mg/day", ")", "and", "C2698196#ent", "<e2>", "(", "10", "mg/day", ")", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2698196", "name": "C2698196#ent", "pos": [19, 20]}}
{"token": ["Ewing", "tumors", "C1705691#ent", "<e1>", ")", "are", "characterized", "by", "rearrangements", "of", "the", "C1704722#ent", "<e2>", "in", "22q12", "and", "a", "high", "MIC2", "expression", "."], "h": {"id": "C1705691", "name": "C1705691#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704722", "name": "C1704722#ent", "pos": [11, 12]}}
{"token": ["These", "oncoproteins", "act", "as", "aberrant", "transcription", "factors", "to", "the", "fusion", "of", "an", "C1705691#ent", "<e1>", "DNA", "binding", "domain", "a", "highly", "potent", "C1704722#ent", "<e2>", "(", "or", "FUS", ")", "transactivation", "domain"], "h": {"id": "C1705691", "name": "C1705691#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704722", "name": "C1704722#ent", "pos": [20, 21]}}
{"token": ["This", "study", "was", "designed", "to", "investigate", "the", "effect", "of", "intravenous", "C0360097#ent", "<e1>", "on", "the", "sympathetic", "activity", "after", "a", "rapid", "increase", "in", "C0063252#ent", "<e2>", "concentration", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0063252", "name": "C0063252#ent", "pos": [21, 22]}}
{"token": ["We", "demonstrate", "that", "PNECs", "in", "usual", "interstitial", "pneumonia", "C1332009#ent", "<e1>", "(", "human", "homolog", "of", "C1332009#ent", "<e1>", ")", "are", "upregulated", "in", "diseased", "lung", "tissues"], "h": {"id": "C1332009", "name": "C1332009#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332009", "name": "C1332009#ent", "pos": [8, 9]}}
{"token": ["Chronic", "venous", "insufficiency", "C4284230#ent", "<e1>", ")", "can", "cause", "C0149745#ent", "<e2>", "of", "the", "lower", "limb", "having", "the", "character", "of", "a", "full", "thickness", "wound", "involving", "the", "subcutaneous", "tissues", "fat", "."], "h": {"id": "C4284230", "name": "C4284230#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149745", "name": "C0149745#ent", "pos": [8, 9]}}
{"token": ["Five", "C0003308#ent", "<e1>", "include", "an", "imidazole", "moiety", "clotrimazole", ",", "miconazole", ",", "C0075503#ent", "<e2>", ",", "tioconazole", ",", "and", "ketoconazole", ")", "were", "examined", "in", "cDNA-expressing", "microsomes", "from", "human", "lymphoblast", "cells", "human", "liver", "microsomes", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0075503", "name": "C0075503#ent", "pos": [11, 12]}}
{"token": ["In", "comparative", "studies", "bifonazole", "was", "significantly", "superior", "to", "placebo", "and", "at", "least", "as", "effective", "as", "alternative", "C0003308#ent", "<e1>", "clotrimazole", ",", "econazole", ",", "miconazole", ",", "oxiconazole", "and", "C0075503#ent", "<e2>", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [16, 17]}, "relation": "therapeutic_class_of", "t": {"id": "C0075503", "name": "C0075503#ent", "pos": [26, 27]}}
{"token": ["Propranolol", ",", "glibenclamide", ",", "tetraethylammonium", "and", "barium", "chloride", "not", "affect", "the", "vasodilation", "induced", "by", "ligustilide", ",", "showing", "that", "C0001644#ent", "<e1>", ",", "ATP", "sensitive", "potassium", "channel", "calcium-activated", "potassium", "channel", "C1416587#ent", "<e2>", "not", "involved", "in", "the", "vasodilatation", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1416587", "name": "C1416587#ent", "pos": [28, 29]}}
{"token": ["In", "one", "variant", "patient", ",", "the", "C3274611#ent", "<e1>", "fusion", "transcript", "contained", "an", "in-frame", "junction", "of", "exon", "9", "C0808901#ent", "<e2>", "to", "exon", "8", "WT1", "."], "h": {"id": "C3274611", "name": "C3274611#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [17, 18]}}
{"token": ["Diphemanil", "10", "mg/kg/24h", "corrected", "the", "C1869199#ent", "<e1>", "and", "Metoclopramide", "1", "mg/kg/24h", "controlled", "52", "%", "of", "the", "C0017168#ent", "<e2>", "."], "h": {"id": "C1869199", "name": "C1869199#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [16, 17]}}
{"token": ["C0028155#ent", "<e1>", "AF-2", "displayed", "greater", "inhibitory", "effect", "than", "did", "C0028156#ent", "<e2>", "a", "mixed", "bacterial", "culture", "including", "several", "proteolytic", "bacteria", "isolated", "from", "shrimp", "was", "subjected", "to", "these", "compounds", "in", "vitro"], "h": {"id": "C0028155", "name": "C0028155#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0028156", "name": "C0028156#ent", "pos": [9, 10]}}
{"token": ["A", "group", "of", "C0028155#ent", "<e1>", "(", "5-nitro-2-furaldehyde", ",", "nifuroxime", ",", "nitrofurazone", ",", "C0028156#ent", "<e2>", ",", "5-nitro-2-furoic", "acid", "and", "2-nitrofuran", ")", "were", "evaluated", "for", "inhibition", "of", "mitogenesis", "(", "DNA", "synthesis", "in", "human", "peripheral", "blood", "T", "cells"], "h": {"id": "C0028155", "name": "C0028155#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C0028156", "name": "C0028156#ent", "pos": [12, 13]}}
{"token": ["C0028155#ent", "<e1>", "are", "widely", "used", "in", "human", "medicine", "as", "C0028156#ent", "<e2>", "and", "nifuroxazide", ",", "still", "prescribed", "for", "long-term", "antimicrobial", "prophylaxis", "urinary", "tract", "gastrointestinal", "infection", "humans", "respectively", "."], "h": {"id": "C0028155", "name": "C0028155#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0028156", "name": "C0028156#ent", "pos": [9, 10]}}
{"token": ["An", "organic", "acid", "from", "purified", "C0085544#ent", "<e1>", "isolated", "from", "a", "nifV", "mutant", "of", "C0519030#ent", "<e2>", "been", "identified", "as", "citric", "acid"], "h": {"id": "C0085544", "name": "C0085544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0519030", "name": "C0519030#ent", "pos": [13, 14]}}
{"token": ["The", "primary", "toxic", "effects", ",", "in", "order", "of", "importance", ",", "C0151773#ent", "<e1>", "phlebosclerosis", ",", "nausea", "and", "vomiting", ",", "and", "C0002170#ent", "<e2>", "."], "h": {"id": "C0151773", "name": "C0151773#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "show", "that", "the", "two", "other", "members", "of", "the", "pocket", "proteins", "family", ",", "p107", "and", "C1423614#ent", "<e1>", ",", "also", "are", "able", "to", "interact", "physically", "with", "C1333891#ent", "<e2>", "in", "live", "cells"], "h": {"id": "C1423614", "name": "C1423614#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [27, 28]}}
{"token": ["Although", "C0808901#ent", "<e1>", "intrinsically", "possessed", "the", "TR2", "domain", ",", "the", "C3274609#ent", "<e2>", "construct", "employed", "lacked", "the", "C0808901#ent", "<e1>", "sequence", "containing", "this", "domain", "."], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [1, 2]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274609", "name": "C3274609#ent", "pos": [10, 11]}}
{"token": ["Identical", "C0808901#ent", "<e1>", "nucleotide", "sequences", "in", "the", "majority", "of", "EWS-FLI1", "and", "C3274609#ent", "<e2>", "chimeric", "transcripts", "are", "fused", "to", "a", "portion", "of", "ETV1", "encoding", "an", "ETS", "domain", "sequence", "specific", "DNA-binding", "activity"], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [1, 2]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274609", "name": "C3274609#ent", "pos": [11, 12]}}
{"token": ["The", "accumulation", "of", "p53", ",", "induction", "of", "p21", ",", "gadd45", ",", "and", "C2985165#ent", "<e1>", ",", "and", "arrest", "of", "the", "cell", "cycle", "G1", "and", "C1422270#ent", "<e2>", "occurred", "normally", "."], "h": {"id": "C2985165", "name": "C2985165#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1422270", "name": "C1422270#ent", "pos": [23, 24]}}
{"token": ["The", "pharmacokinetics", "and", "C0001644#ent", "<e1>", "blocking", "effects", "of", "conventional", "and", "sustained-release", "C0041030#ent", "<e2>", "have", "been", "studied", "in", "6", "healthy", "male", "volunteers", "given", "a", "single", "oral", "dose", "40", "mg", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041030", "name": "C0041030#ent", "pos": [11, 12]}}
{"token": ["The", "serotonergic", "blocker", ",", "C0025842#ent", "<e1>", ",", "and", "the", "cholinergic", "blocker", "C0036442#ent", "<e2>", ",", "did", "not", "produce", "any", "consistent", "changes", "in", "the", "intensity", "of", "the", "response", "."], "h": {"id": "C0025842", "name": "C0025842#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [11, 12]}}
{"token": ["This", "article", "discusses", "MR", "imaging", "infective", "liver", "lesions", "C0003869#ent", "<e1>", "liver", "abscesses", "amebic", "liver", "abscesses", "echinococcal", "disease", "hepatic", "fungal", "abscesses", "granulomatous", "hepatic", "infections", "schistosomiasis", ",", "and", "C0015655#ent", "<e2>", "."], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015655", "name": "C0015655#ent", "pos": [26, 27]}}
{"token": ["In", "vitro", "Matrigel", "invasion", "assays", "showed", "that", "induction", "of", "C1538714#ent", "<e1>", "expression", "by", "C1512474#ent", "<e2>", "human", "cancer", "cells", "in", "a", "significant", "increase", "of", "cancer", "cell", "invasion"], "h": {"id": "C1538714", "name": "C1538714#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1512474", "name": "C1512474#ent", "pos": [13, 14]}}
{"token": ["Aside", "from", "C1366535#ent", "<e1>", "other", "features", "of", "C0242342#ent", "<e2>", "seldom", "been", "reported", "and", "no", "patients", "have", "presented", "with", "a", "hypothalamic", "tumor"], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242342", "name": "C0242342#ent", "pos": [7, 8]}}
{"token": ["The", "C0235480#ent", "<e1>", "and", "Pax-8", "genes", "be", "important", "C1332430#ent", "<e2>", "downstream", "genes", "the", "BMP", "signaling", "pathway", "during", "interventricular", "septum", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332430", "name": "C1332430#ent", "pos": [8, 9]}}
{"token": ["The", "number", "of", "Mac-1", "+", "cells", "in", "PP", "and", "C1417190#ent", "<e1>", "increased", "after", "C0032064#ent", "<e2>", "and", "recruitment", "of", "these", "cells", "was", "not", "blocked", "by", "administration", "of", "anticytokine", "or", "anti-integrin", "antibodies", "."], "h": {"id": "C1417190", "name": "C1417190#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032064", "name": "C0032064#ent", "pos": [13, 14]}}
{"token": ["GARPs", "exist", "as", "two", "soluble", "forms", ",", "C3714920#ent", "<e1>", "and", "GARP2", ",", "and", "as", "a", "large", "cytoplasmic", "domain", "C1413546#ent", "<e2>", "'", "part", ")", "of", "the", "beta-subunit", "of", "the", "cyclic", "GMP-gated", "channel", "."], "h": {"id": "C3714920", "name": "C3714920#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413546", "name": "C1413546#ent", "pos": [18, 19]}}
{"token": ["The", "authors", "report", "3", "cases", "of", "C0027121#ent", "<e1>", "associated", "with", "pulmonary", "lesions", "preceded", "or", "succeeded", "the", "C0026848#ent", "<e2>"], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [16, 17]}}
{"token": ["C1332735#ent", "<e1>", "mediates", "disruption", "of", "the", "interaction", "between", "p53", "and", "C0812222#ent", "<e2>", "(", "also", "known", "as", "Mdm2", ")", ",", "and", "prevents", "Hdm2-induced", "p53", "ubiquitylation", "and", "downregulation", "."], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [10, 11]}}
{"token": ["Fourteen", "slightly", "disabled", "patients", "with", "C0030567#ent", "<e1>", "were", "treated", "separately", "with", "benzhexol", ",", "C0002403#ent", "<e2>", ",", "and", "levodopa", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0002403", "name": "C0002403#ent", "pos": [13, 14]}}
{"token": ["C0886883#ent", "<e1>", "an", "effective", "anticonvulsant", ",", "C0242911#ent", "<e2>", ",", "and", "migraine", "prophylaxis", "agent"], "h": {"id": "C0886883", "name": "C0886883#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0242911", "name": "C0242911#ent", "pos": [6, 7]}}
{"token": ["This", "YAC", "fell", "immediately", "C0087071#ent", "<e1>", "of", "the", "C1414688#ent", "<e2>", "(", "FKHR", ")", "gene", ",", "which", "is", "disrupted", "in", "the", "t(2;13)(q35;q14", ")", "seen", "in", "pediatric", "alveolar", "rhabdomyosarcoma"], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414688", "name": "C1414688#ent", "pos": [8, 9]}}
{"token": ["L-DOPS", "was", "administered", "simultaneously", "with", "C0005014#ent", "<e1>", "(", "BSZ", ";", "a", "C1412028#ent", "<e2>", ",", "and", "the", "regional", "contents", "of", "NE", "in", "the", "cerebral", "cortex", "hippocampus", ",", "and", "cerebellum", "were", "assayed", "."], "h": {"id": "C0005014", "name": "C0005014#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412028", "name": "C1412028#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "we", "determined", "that", "C1367307#ent", "<e1>", "expression", "is", "required", "for", "PDGF-mediated", "regulation", "of", "cell", "cycle", "C1413175#ent", "<e2>", "p27", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413175", "name": "C1413175#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "and", "compare", "the", "prevalence", "and", "degree", "of", "autonomic", "(", "ANP", ")", "and", "C1112256#ent", "<e1>", "SNP", ")", "in", "patients", "with", "systemic", "lupus", "erythematosus", "C0014060#ent", "<e2>", ")", "and", "systemic", "sclerosis", "SSc", ")", "."], "h": {"id": "C1112256", "name": "C1112256#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [24, 25]}}
{"token": ["In", "spite", "of", "the", "modest", "means", "of", "the", "centre", "(", "use", "of", "C0000975#ent", "<e1>", ",", "lack", "of", "C0376541#ent", "<e2>", "limited", "biological", "controls", "the", "foetus", "could", "be", "kept", "by", "intensification", "of", "the", "dialysis", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0376541", "name": "C0376541#ent", "pos": [17, 18]}}
{"token": ["Host", "mice", "depleted", "in", "vivo", "CD4", "or", "CD8", "T", "cells", "vDLN", "C4049878#ent", "<e1>", "to", "ascertain", "the", "C0127400#ent", "<e2>", "of", "tumor", "regression"], "h": {"id": "C4049878", "name": "C4049878#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "3", "patients", "with", "this", "C1848862#ent", "<e1>", "and", "frequent", "C0270820#ent", "<e2>"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0270820", "name": "C0270820#ent", "pos": [10, 11]}}
{"token": ["Binding", "to", "C1418944#ent", "<e1>", "was", "characterized", "by", "a", "solid", "phase", "binding", "assay", ",", "demonstrating", "that", "95", "%", "of", "isolated", "C0030956#ent", "<e2>", "were", "specific", "for", "C1418944#ent", "<e1>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418944", "name": "C1418944#ent", "pos": [2, 3]}}
{"token": ["No", "additive", "effects", "of", "VIP-", "and", "GHRH-stimulated", "cAMP", "generation", "were", "observed", ",", "suggesting", "that", "both", "C0030956#ent", "<e1>", "compete", "for", "the", "same", "C1418944#ent", "<e2>"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418944", "name": "C1418944#ent", "pos": [21, 22]}}
{"token": ["We", "sequenced", "the", "29,751-base", "genome", "of", "the", "severe", "C0035222#ent", "<e1>", "coronavirus", "known", "as", "the", "C4284889#ent", "<e2>", "isolate", "."], "h": {"id": "C0035222", "name": "C0035222#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284889", "name": "C4284889#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "treatment", "of", "CRC", "cells", "with", "C1176309#ent", "<e1>", "down-regulated", "the", "expression", "of", "XIAP", ",", "C1705838#ent", "<e2>", ",", "and", "survivin", "."], "h": {"id": "C1176309", "name": "C1176309#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705838", "name": "C1705838#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "phenol", ",", "C0018304#ent", "<e1>", "and", "m-cresol", "on", "erythrocytes", ",", "hepatocytes", ",", "C0216971#ent", "<e2>", "and", "surface", "tension", "studied", "at", "various", "concentrations", "."], "h": {"id": "C0018304", "name": "C0018304#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0216971", "name": "C0216971#ent", "pos": [14, 15]}}
{"token": ["The", "dynamic", "changes", "in", "impedance", "did", "not", "correlate", "directly", "with", "either", "tissue", "perfusion", "C2975867#ent", "<e1>", ",", "but", "instead", "correlated", "well", "with", "the", "C0720099#ent", "<e2>", "of", "ischemia", "."], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [22, 23]}}
{"token": ["Preliminary", "experiments", "some", "analogy", "between", "the", "peritubular", "cell", "factors", "that", "stimulate", "C1366439#ent", "<e1>", "production", "and", "those", "that", "inhibit", "C0003805#ent", "<e2>", "induction", "."], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [18, 19]}}
{"token": ["Because", "of", "the", "inability", "of", "normal", "skin", "epidermis", "to", "desaturate", "LA", "to", "C0061078#ent", "<e1>", "it", "is", "transformed", "by", "C0003692#ent", "<e2>", "mainly", "13-hydroxyoctadecadienoic", "acid", "which", "functionally", "exerts", "antiproliferative", "properties", "the", "tissue", "."], "h": {"id": "C0061078", "name": "C0061078#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003692", "name": "C0003692#ent", "pos": [18, 19]}}
{"token": ["In", "C0700251#ent", "<e1>", ",", "ability", "to", "elicit", "an", "C1332807#ent", "<e2>", "several", "days", "after", "onset", "of", "paresis", "was", "good", "evidence", "of", "neuronal", "continuity", "in", "motor", "fibers"], "h": {"id": "C0700251", "name": "C0700251#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [8, 9]}}
{"token": ["The", "fact", "that", "hamartomas", ",", "lung", "cysts", "and", "renal", "cell", "carcinoma", "also", "occur", "in", "tuberous", "sclerosis", "complex", "C1420092#ent", "<e1>", ")", "suggests", "that", "the", "BHD", "and", "C1420092#ent", "<e1>", "C0086376#ent", "<e1>", "may", "function", "within", "a", "common", "pathway", "."], "h": {"id": "C1420092", "name": "C1420092#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [27, 28]}}
{"token": ["Expression", "of", "C1539205#ent", "<e1>", "was", "also", "found", "to", "inhibit", "the", "repair", "activities", "the", "C.", "trachomatis", "C1419240#ent", "<e2>", "not", "recombination", "."], "h": {"id": "C1539205", "name": "C1539205#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419240", "name": "C1419240#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "these", "C0991617#ent", "<e1>", "had", "no", "substantial", "effect", "on", "C1415652#ent", "<e2>", "and", "COX-2", "expression", "in", "peritoneal", "macrophages", "women", "with", "endometriosis", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [11, 12]}}
{"token": ["C0991617#ent", "<e1>", "that", "inhibit", "COX-2", "while", "sparing", "C1415652#ent", "<e2>", "represent", "a", "new", "attractive", "therapeutic", "development", "could", "represent", "a", "major", "advance", "in", "the", "treatment", "of", "rheumatoid", "arthritis", "osteoarthritis", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [7, 8]}}
{"token": ["However", ",", "SUPERMIX", "lacks", "CYP2B6", "activity", "did", "not", "hydroxylate", "the", "antidepressant", "C0700563#ent", "<e1>", ",", "a", "clinically", "relevant", "substrate", "of", "this", "C0014442#ent", "<e2>", "."], "h": {"id": "C0700563", "name": "C0700563#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}}
{"token": ["This", "study", "demonstrates", "that", "alcohol", "dehydrogenase", "C0001985#ent", "<e1>", "present", "in", "the", "C0771711#ent", "<e2>", "."], "h": {"id": "C0001985", "name": "C0001985#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [11, 12]}}
{"token": ["Hospital", "inpatient", "records", "a", "disproportionate", "number", "of", "children", "with", "C0159020#ent", "<e1>", "simple", "partial", "epilepsy", ",", "and", "partial", "C0036572#ent", "<e2>", "secondarily", "generalised", ",", "and", "children", "with", "multiple", "developmental", "handicaps", "."], "h": {"id": "C0159020", "name": "C0159020#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "mutant", "C1415504#ent", "<e1>", "specifically", "affects", "C1538565#ent", "<e2>", "and", "not", "p300", "both", "at", "the", "early", "and", "later", "time", "points", "via", "multiple", "mechanisms", "."], "h": {"id": "C1415504", "name": "C1415504#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1538565", "name": "C1538565#ent", "pos": [7, 8]}}
{"token": ["These", "suppressive", "effects", "of", "p15-like", "factors", "can", "be", "neutralized", "in", "vitro", "C0030956#ent", "<e1>", "such", "as", "thymostimulin", "(", "C1420830#ent", "<e2>", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420830", "name": "C1420830#ent", "pos": [17, 18]}}
{"token": ["The", "hepatic-", "and", "renal-specific", "expression", "of", "C0002083#ent", "<e1>", "coincides", "with", "the", "distribution", "of", "C0041931#ent", "<e2>", "these", "tissues", "in", "the", "frog", "."], "h": {"id": "C0002083", "name": "C0002083#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041931", "name": "C0041931#ent", "pos": [13, 14]}}
{"token": ["C0002083#ent", "<e1>", "but", "little", "C0041931#ent", "<e2>", "was", "found", "in", "extracts", "of", "leaflets", ",", "pods", ",", "and", "seeds", "."], "h": {"id": "C0002083", "name": "C0002083#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041931", "name": "C0041931#ent", "pos": [4, 5]}}
{"token": ["When", "C1417613#ent", "<e1>", "were", "digested", "with", "C0012906#ent", "<e2>", "sites", "within", "the", "coding", "region", "accessible", "and", "sites", "in", "the", "non-transcribed", "region", "were", "protected", "."], "h": {"id": "C1417613", "name": "C1417613#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [6, 7]}}
{"token": ["Associations", "between", "polymorphisms", "of", "DMA", "and", "C0058272#ent", "<e1>", "alleles", "and", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e2>", ")", "were", "studied", "in", "51", "Japanese", "C0024141#ent", "<e2>", "patients", "and", "77", "normal", "subjects", "the", "polymerase", "chain", "reaction-restriction", "fragment", "length", "polymorphism", "PCR-RFLP", ")", "method", "."], "h": {"id": "C0058272", "name": "C0058272#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [13, 14]}}
{"token": ["These", "data", "suggest", "that", "neither", "the", "DMA", "nor", "the", "C0058272#ent", "<e1>", "susceptibility", "to", "C0024141#ent", "<e2>", "in", "Japanese", "."], "h": {"id": "C0058272", "name": "C0058272#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [13, 14]}}
{"token": ["The", "human", "C1332667#ent", "<e1>", "whose", "product", "is", "also", "known", "as", "C1332667#ent", "<e1>", "FLICE", ",", "encodes", "an", "interleukin-1beta", "converting", "enzyme", "(ICE)-related", "cysteine", "protease", "is", "activated", "by", "the", "engagement", "of", "several", "different", "death", "receptors"], "h": {"id": "C1332667", "name": "C1332667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332667", "name": "C1332667#ent", "pos": [2, 3]}}
{"token": ["In", "addition", "to", "inhibiting", "the", "C0171406#ent", "<e1>", "toxins", "known", "to", "cause", "Parkinson's", "disease", "C3160718#ent", "<e2>", ")", ",", "such", "as", "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine", "and", "rotenone", ",", "also", "strongly", "depolymerize", "microtubules", "and", "increase", "tubulin", "degradation", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [13, 14]}}
{"token": ["Complex", "I", "genotype", "variation", "commonly", "occurs", "and", "may", "explain", "why", "particular", "C0171406#ent", "<e1>", "polymorphisms", "associate", "with", "C3160718#ent", "<e2>", "in", "some", "populations", "but", "not", "others", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [16, 17]}}
{"token": ["In", "suicide", "gene", "therapy", "the", "inclusion", "of", "the", "C1865068#ent", "<e1>", "target", "sequences", "in", "the", "C0879457#ent", "<e2>", "expression", "cassette", "achieved", "not", "only", "significant", "antitumor", "effects", "but", "also", "a", "dramatic", "reduction", "in", "HSVtk/GCV-induced", "hepatotoxicity", "."], "h": {"id": "C1865068", "name": "C1865068#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0879457", "name": "C0879457#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrate", "that", "both", "C0067533#ent", "<e1>", "and", "the", "catalytic", "subunit", "PKA", "coimmunoprecipitate", "with", "C0252534#ent", "<e2>", "isolated", "from", "HEK-293", "cell", "extracts", "and", "that", "PKA", "catalytic", "activity", "enriched", "in", "C0252534#ent", "<e2>", "immunoprecipitates", "."], "h": {"id": "C0067533", "name": "C0067533#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0252534", "name": "C0252534#ent", "pos": [13, 14]}}
{"token": ["A", "nonobese", "diabetic", "NOD", ")", "mouse", ",", "which", "shares", "many", "features", "of", "human", "C0011854#ent", "<e1>", "is", "an", "ideal", "model", "for", "evaluating", "the", "function", "of", "C2982447#ent", "<e2>", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2982447", "name": "C2982447#ent", "pos": [24, 25]}}
{"token": ["Angiotensin", "II", "stimulation", "increases", "the", "formation", "of", "reactive", "oxygen", "species", "ROS", ")", ",", "the", "phosphorylation", "of", "C1456378#ent", "<e1>", "MAPK", ")", ",", "and", "the", "expression", "of", "transforming", "growth", "factor", "beta", "C1366557#ent", "<e2>", ")", "in", "adult", "cardiomyocytes", "."], "h": {"id": "C1456378", "name": "C1456378#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1366557", "name": "C1366557#ent", "pos": [29, 30]}}
{"token": ["Based", "on", "the", "definition", "of", "kl", "as", "the", "derivative", "of", "the", "ratio", "of", "C0266815#ent", "<e1>", "from", "C3538757#ent", "<e2>", "to", "C3538757#ent", "<e2>", "directed", "towards", "milk", "production", ",", "MEm", "and", "kl", "were", "determined", "."], "h": {"id": "C0266815", "name": "C0266815#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3538757", "name": "C3538757#ent", "pos": [16, 17]}}
{"token": ["C2987364#ent", "<e1>", "Escherichia", "coli", "not", "grow", "on", "C0002253#ent", "<e2>", ";", "mutants", "that", "can", "do", "so", "have", "increased", "basal", "activity", "an", "NAD-linked", "L-1,2-propanediol", "oxidoreductase", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002253", "name": "C0002253#ent", "pos": [7, 8]}}
{"token": ["Cytochalasin", "B", "but", "not", "nocodazole", "or", "taxol", ",", "deformed", "the", "aggregation", "of", "C1332695#ent", "<e1>", "mRNA", ",", "indicating", "the", "involvement", "of", "C1334752#ent", "<e2>", "in", "organizing", "this", "form", "."], "h": {"id": "C1332695", "name": "C1332695#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334752", "name": "C1334752#ent", "pos": [20, 21]}}
{"token": ["IHA", "patients", "proved", "to", "be", "more", "responsive", "to", "angiotensin", "II", "and", ",", "in", "contrast", ",", "C1414406#ent", "<e1>", "cases", "proved", "to", "be", "more", "sensitive", "to", "C1704793#ent", "<e2>", "."], "h": {"id": "C1414406", "name": "C1414406#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [24, 25]}}
{"token": ["Because", "the", "DDB2", "subunit", "C0388638#ent", "<e1>", "is", "required", "for", "the", "nuclear", "accumulation", "C1413941#ent", "<e2>", ",", "we", "investigated", "the", "role", "of", "DDB2", "in", "the", "nuclear", "accumulation", "HBx", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413941", "name": "C1413941#ent", "pos": [12, 13]}}
{"token": ["Similar", "C2697827#ent", "<e1>", "were", "also", "observed", "in", "muscles", "with", "gap", "junction", "channels", "inhibited", "by", "C0019223#ent", "<e2>", "."], "h": {"id": "C2697827", "name": "C2697827#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019223", "name": "C0019223#ent", "pos": [14, 15]}}
{"token": ["The", "C1705008#ent", "<e1>", "agonist", "imiquimod", "is", "currently", "used", "as", "a", "topical", "treatment", "C0009663#ent", "<e2>", "by", "human", "papillomavirus", "HPV", ")", ",", "actinic", "keratosis", "AK", ")", "and", "superficial", "basal", "cell", "carcinoma"], "h": {"id": "C1705008", "name": "C1705008#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009663", "name": "C0009663#ent", "pos": [12, 13]}}
{"token": ["The", "family", "history", "that", "their", "father", "and", "grandfather", "suffered", "from", "C0022661#ent", "<e1>", "suggesting", "that", "C0268743#ent", "<e2>", "seen", "in", "the", "present", "sibling", "cases", "hereditary", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268743", "name": "C0268743#ent", "pos": [14, 15]}}
{"token": ["To", "address", "the", "issue", ",", "we", "observed", "the", "reduction", "of", "N:-nitrosomethylbenzylamine", "(NMBA)-induced", "tumorigenesis", "in", "rat", "C0014868#ent", "<e1>", "via", "JTE-522", "(", "4-[4-cyclohexyl-2-methyloxazol-5-yl]-2-fluorobenzenesulfonamide", ")", ",", "a", "selective", "C1705323#ent", "<e2>", "inhibitor", "."], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [25, 26]}}
{"token": ["Therefore", ",", "the", "modified", "protein", "and", "not", "some", "fraction", "resistant", "to", "labeling", ")", "is", "active", "toward", "the", "mammalian", "C3541394#ent", "<e1>", "but", "inactive", "toward", "plant", "C1826342#ent", "<e2>"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1826342", "name": "C1826342#ent", "pos": [24, 25]}}
{"token": ["Momordin", "Ic", "and", "oleanolic", "acid", "from", "C1427198#ent", "<e1>", "appear", "to", "contribute", "to", "alleviating", "the", "adverse", "effects", "C3887559#ent", "<e2>", "treatment", "by", "enhancing", "the", "hepatic", "antioxidant", "defense", "system", "."], "h": {"id": "C1427198", "name": "C1427198#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3887559", "name": "C3887559#ent", "pos": [16, 17]}}
{"token": ["4", ")", "C1420554#ent", "<e1>", "is", "present", "in", "the", "membranes", "of", "vesicles", "carrying", "C1420563#ent", "<e2>", "."], "h": {"id": "C1420554", "name": "C1420554#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420563", "name": "C1420563#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "transforming", "growth", "factor-beta", "cultured", "aortic", "smooth", "muscle", "cells", "that", "this", "C1333196#ent", "<e1>", "may", "be", "an", "important", "mediator", "of", "C1414382#ent", "<e2>", "formation", "during", "atherosclerosis", "and", "hypertension", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [21, 22]}}
{"token": ["These", "results", "indicate", "that", "C0700541#ent", "<e1>", "facilitates", "excitatory", "synaptic", "transmission", "activating", "NMDA", "receptors", "C0001644#ent", "<e2>", "under", "conditions", "in", "which", "NMDA", "receptor", "channel", "block", "slight", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [13, 14]}}
{"token": ["The", "insecticidal", "activity", "of", "C0961781#ent", "<e1>", "was", "evaluated", "against", "susceptible", "and", "permethrin-resistant", "human", "C0030756#ent", "<e2>", "."], "h": {"id": "C0961781", "name": "C0961781#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0030756", "name": "C0030756#ent", "pos": [13, 14]}}
{"token": ["Synovial", "fluid", "C1704887#ent", "<e1>", ")", "and", "synovial", "tissue", "10", "patients", "with", "C3495559#ent", "<e2>", "examined", "."], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [11, 12]}}
{"token": ["Synovial", "fluid", "C1704887#ent", "<e1>", ")", ",", "obtained", "from", "patients", "with", "C3495559#ent", "<e2>", "JRA", ")", ",", "osteochondritis", ",", "traumatic", "synovitis", "septic", "arthritis", "tested", "for", "the", "presence", "of", "thymocytotoxic", "activity", "."], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [10, 11]}}
{"token": ["By", "immunoprecipitation", "from", "HeLa", "extract", "we", "found", "that", "C1845055#ent", "<e1>", "is", "in", "a", "complex", "with", "transcription", "cofactor", "C1333203#ent", "<e2>", "."], "h": {"id": "C1845055", "name": "C1845055#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333203", "name": "C1333203#ent", "pos": [17, 18]}}
{"token": ["The", "three-layered", "peritrophic", "matrix", "of", "Glossina", "morsitans", "morsitans", "shown", ",", "by", "histochemistry", ",", "to", "be", "formed", "of", "a", "mixture", "of", "C3536869#ent", "<e1>", ",", "glycoproteins", "and", "C0008145#ent", "<e2>", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0008145", "name": "C0008145#ent", "pos": [25, 26]}}
{"token": ["C0017040#ent", "<e1>", "(", "GGT", ",", "EC", "2.3.2.2", ")", "is", "an", "C0014442#ent", "<e2>", "involved", "in", "glutathione", "metabolism", "drug", "and", "xenobiotic", "detoxification"], "h": {"id": "C0017040", "name": "C0017040#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["The", "old", "term", "proposed", "by", "Walton", ",", "was", "benign", "congenital", "hypotonia", "denoting", "the", "presence", "of", "C0030552#ent", "<e1>", "hypotonia", ",", "with", "the", "exception", "of", "C0043116#ent", "<e2>"], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0043116", "name": "C0043116#ent", "pos": [23, 24]}}
{"token": ["Strong", "C0040034#ent", "<e1>", "is", "observed", "during", "acute", "infection", "Trypanosoma", "cruzi", "the", "parasitic", "protozoan", "of", "C0041234#ent", "<e2>", "Chagas'", "disease"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041234", "name": "C0041234#ent", "pos": [14, 15]}}
{"token": ["Strong", "C0040034#ent", "<e1>", "is", "observed", "during", "acute", "infection", "Trypanosoma", "cruzi", "the", "parasitic", "protozoan", "of", "American", "trypanosomiasis", "C0041234#ent", "<e2>"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041234", "name": "C0041234#ent", "pos": [16, 17]}}
{"token": ["This", "C0021847#ent", "<e1>", "is", "characterized", "by", "C3714552#ent", "<e2>", "and", "numbness", "of", "the", "hands", "and", "feet", "in", "association", "with", "hyperalgesia", "of", "the", "palmar", "surface", "of", "the", "hands", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [6, 7]}}
{"token": ["We", "previously", "demonstrated", "that", "the", "steady-state", "levels", "of", "the", "GHR", "and", "C1415063#ent", "<e1>", "mRNAs", "are", "significantly", "elevated", "in", "mouse", "C0023899#ent", "<e2>", "during", "pregnancy", "."], "h": {"id": "C1415063", "name": "C1415063#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}}
{"token": ["At", "day", "20f", "C1415063#ent", "<e1>", "mRNA", "levels", "were", "higher", "in", "lung", "than", "in", "C0023899#ent", "<e2>", ",", "whereas", "growth", "hormone", "binding", "protein", "mRNA", "levels", "were", "approximately", "equal", "in", "lung", "and", "C0023899#ent", "<e2>", "."], "h": {"id": "C1415063", "name": "C1415063#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "C1418850#ent", "<e1>", "PP", ")", "activity", "and", "the", "expression", "of", "C1704708#ent", "<e2>", "during", "growth", "and", "differentiation", "of", "epidermal", "keratinocytes", "culture", "."], "h": {"id": "C1418850", "name": "C1418850#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [11, 12]}}
{"token": ["The", "results", "demonstrate", "that", "the", "autophosphorylation-activated", "protein", "kinase", "only", "inactivates", "the", "C1418850#ent", "<e1>", "but", "also", "the", "protein", "tyrosine", "phosphatase", "activity", "of", "C1704708#ent", "<e2>", "."], "h": {"id": "C1418850", "name": "C1418850#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [21, 22]}}
{"token": ["The", "purified", "C0014442#ent", "<e1>", "has", "a", "specific", "arabinofuranose-debranching", "activity", "on", "C0059100#ent", "<e2>", "from", "Gramineae", ",", "acts", "synergistically", "with", "the", "S.", "lividans", "xylanases", "and", "binds", "specifically", "to", "C0059100#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0059100", "name": "C0059100#ent", "pos": [10, 11]}}
{"token": ["The", "results", "for", "C0007367#ent", "<e1>", "were", "compared", "with", "those", "for", "fatty", "acyl-CoA", "oxidase", "C0937932#ent", "<e2>", "of", "which", "were", "indicated", "as", "showing", "a", "closer", "association", "with", "the", "peroxisomal", "compartment", "was", "the", "case", "for", "C0007367#ent", "<e1>", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0937932", "name": "C0937932#ent", "pos": [13, 14]}}
{"token": ["While", "C0007367#ent", "<e1>", "is", "transferred", "uniformly", "to", "all", "new", "segments", ",", "C0937932#ent", "<e2>", "is", "compartmentalized", "in", "certain", "portions", ",", "of", "the", "apparently", "growing", "\"", "peroxisomal", "reticulum", "\"", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0937932", "name": "C0937932#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "his", "factor", "X", "gene", "a", "single", "point", "mutation", "within", "exon", "II", "in", "the", "substitution", "of", "+", "25", "Gla", "(", "C1414899#ent", "<e1>", ")", "by", "Lys", "(", "C0162871#ent", "<e2>", ")", "."], "h": {"id": "C1414899", "name": "C1414899#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0162871", "name": "C0162871#ent", "pos": [27, 28]}}
{"token": ["Both", "C0071516#ent", "<e1>", "and", "polyglutamate", "blocked", "C1705159#ent", "<e2>", "and", "chylomicron", "binding", "GPIHBP1", "."], "h": {"id": "C0071516", "name": "C0071516#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705159", "name": "C1705159#ent", "pos": [6, 7]}}
{"token": ["Nail-patella", "syndrome", "C0027341#ent", "<e1>", ")", "is", "characterized", "by", "developmental", "defects", "dorsal", "limb", "structures", "nephropathy", ",", "and", "C0017601#ent", "<e2>", "and", "is", "caused", "by", "heterozygous", "mutations", "the", "LIM", "homeodomain", "transcription", "factor", "LMX1B", "."], "h": {"id": "C0027341", "name": "C0027341#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [16, 17]}}
{"token": ["Mutants", "in", "C1332428#ent", "<e1>", "displayed", "decreased", "levels", "of", "meiotic", "C0014877#ent", "<e2>", "over", "and", "intragenic", "recombination", "markers", "on", "homologous", "chromosomes"], "h": {"id": "C1332428", "name": "C1332428#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014877", "name": "C0014877#ent", "pos": [9, 10]}}
{"token": ["The", "pharmacokinetics", "of", "norfloxacin", "(", "NFLX", ")", "was", "studied", "in", "5", "patients", "with", "C1561643#ent", "<e1>", "rats", "with", "C0035066#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035066", "name": "C0035066#ent", "pos": [17, 18]}}
{"token": ["This", "feature", "will", "review", "these", "new", "C0035064#ent", "<e1>", "including", "zanolimumab", ",", "C0717670#ent", "<e2>", "bexarotene", ",", "and", "vorinostat", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0717670", "name": "C0717670#ent", "pos": [11, 12]}}
{"token": ["Other", "C0035064#ent", "<e1>", "that", "are", "being", "studied", "include", "C0717670#ent", "<e2>", "Ontak", ")", ",", "and", "bcl-2", "antisense", "G3139", ",", "Genasense", "]", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0717670", "name": "C0717670#ent", "pos": [8, 9]}}
{"token": ["The", "C3537369#ent", "<e1>", "and", "med-2", "genes", "encode", "small", ",", "highly", "similar", "C0086376#ent", "<e2>", "related", "to", "GATA-type", "transcription", "factors", "have", "been", "proposed", "as", "necessary", "for", "specification", "of", "both", "the", "mesoderm", "and", "the", "endoderm", "of", "Caenorhabditis", "elegans"], "h": {"id": "C3537369", "name": "C3537369#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Instead", ",", "decreased", "phosphorylation", "of", "C1705633#ent", "<e1>", "may", "be", "due", "to", "increased", "expression", "of", "C0096069#ent", "<e2>", "particularly", "the", "p38/ERK", "phosphatase", "PAC1", "(", "phosphatase", "of", "activated", "cells", "."], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0096069", "name": "C0096069#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "certain", "mutations", "of", "the", "C1412481#ent", "<e1>", "associated", "with", "recently", "described", "C0022658#ent", "<e2>", ",", "termed", "lipoprotein", "glomerulopathy"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [12, 13]}}
{"token": ["There", "are", "conflicting", "results", "regarding", "the", "effect", "of", "apolipoprotein", "(", "C1412481#ent", "<e1>", ")", "polymorphisms", "on", "the", "progression", "of", "a", "variety", "of", "C0022658#ent", "<e2>"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [21, 22]}}
{"token": ["Six", "major", "sequence", "types", "of", "C1419805#ent", "<e1>", "were", "identified", ",", "which", "were", "subdivided", "into", "70", "C0002085#ent", "<e2>", ";", "however", ",", "only", "50", "%", "of", "isolates", "were", "typeable", "."], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [15, 16]}}
{"token": ["C1620185#ent", "<e1>", "catalytic", "activities", "by", "30-", "to", "40-fold", ",", "whereas", "C0919426#ent", "<e2>", "activities", "varied", "by", "6-", "to", "20-fold", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919426", "name": "C0919426#ent", "pos": [10, 11]}}
{"token": ["These", "data", "contrast", "with", "other", "studies", "that", "have", "demonstrated", "analgesia", "using", "C0007680#ent", "<e1>", "antihistamines", "such", "as", "hydroxyzine", ",", "phenyltoloxamine", ",", "or", "C0029309#ent", "<e2>", "."], "h": {"id": "C0007680", "name": "C0007680#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029309", "name": "C0029309#ent", "pos": [21, 22]}}
{"token": ["Overexpression", "of", "C2987364#ent", "<e1>", "or", "catalytically", "inactive", "C3814147#ent", "<e2>", "reduced", "or", "enhanced", ",", "respectively", ",", "basal", "and", "EGF-induced", "EGFR", "tyrosine", "phosphorylation", "in", "human", "keratinocytes", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3814147", "name": "C3814147#ent", "pos": [7, 8]}}
{"token": ["Plasma", "AP", "was", "also", "measured", "in", "some", "patients", "after", "the", "iv", "infusion", "of", "1", "L", "150", "mmol/L", "C1412125#ent", "<e1>", "and", "after", "treatment", "of", "C0020550#ent", "<e2>", "or", "hypothyroidism", "."], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [23, 24]}}
{"token": ["von", "C0042974#ent", "<e1>", "vWD", ")", "is", "the", "most", "common", "C0005779#ent", "<e2>", "is", "due", "to", "a", "quantitative", "and/or", "qualitative", "deficiency", "von", "Willebrand's", "factor", "vWF", ")", "."], "h": {"id": "C0042974", "name": "C0042974#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "report", "the", "characterization", "of", "a", "mouse", "model", "the", "C0005129#ent", "<e1>", "by", "a", "targeted", "disruption", "of", "the", "C0079429#ent", "<e2>", "encoding", "the", "glycoprotein", "(", "GP", ")", "Ibbeta", "subunit", "of", "the", "GP", "Ib-IX", "complex"], "h": {"id": "C0005129", "name": "C0005129#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}}
{"token": ["L90", "M", ",", "G48V", ",", "and", "L90M/G48V", "proteases", "have", "1/20", ",", "1/160", ",", "and", "1/1000", "the", "affinity", "for", "C0286738#ent", "<e1>", "compared", "to", "C1947941#ent", "<e2>", "respectively", "."], "h": {"id": "C0286738", "name": "C0286738#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [22, 23]}}
{"token": ["Here", ",", "we", "show", "that", "the", "C3273837#ent", "<e1>", "activity", "of", "the", "yeast", "C3890017#ent", "<e2>", "Sse1", "itself", "is", "controlled", "by", "nucleotide", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3890017", "name": "C3890017#ent", "pos": [12, 13]}}
{"token": ["C0812246#ent", "<e1>", "enhanced", "CGT", ",", "C1512213#ent", "<e2>", "and", "GalT6", "mRNA", "levels", "and", "EGCG", "suppressed", "the", "level", "of", "these", "enzymes", "enhanced", "by", "C0812246#ent", "<e1>", "treatment", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512213", "name": "C1512213#ent", "pos": [5, 6]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "determine", "the", "relative", "efficacy", "of", "C0076107#ent", "<e1>", "vs.", "C0076107#ent", "<e1>", "and", "C0016384#ent", "<e1>", "(", "combination", "therapy", "for", "the", "treatment", "of", "symptomatic", "BPH", "."], "h": {"id": "C0076107", "name": "C0076107#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0016384", "name": "C0016384#ent", "pos": [19, 20]}}
{"token": ["The", "role", "of", "C1422070#ent", "<e1>", "as", "one", "of", "the", "causes", "provoking", "pemphigus", "vulgaris", "C0042109#ent", "<e2>", "raised", "anti-skin", "antibodies", "is", "discussed", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [13, 14]}}
{"token": ["There", "was", "one", "case", "of", "C0275686#ent", "<e1>", "associated", "with", "pregnancy", "and", "one", "case", "of", "C0521173#ent", "<e2>", "infanti", "septica", "."], "h": {"id": "C0275686", "name": "C0275686#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0521173", "name": "C0521173#ent", "pos": [14, 15]}}
{"token": ["Plasma", "levels", "of", "C1708120#ent", "<e1>", "probably", "reflect", "the", "concentration", "of", "C0023899#ent", "<e2>", "GHRs", "."], "h": {"id": "C1708120", "name": "C1708120#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["Exogenous", "bGH", "given", "continuously", "normalized", "the", "C0023899#ent", "<e1>", "GHR", ",", "serum", "C1708120#ent", "<e2>", "and", "their", "C0023899#ent", "<e1>", "mRNAs", ",", "as", "well", "as", "circulating", "IGFBPs", "."], "h": {"id": "C1708120", "name": "C1708120#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}}
{"token": ["To", "investigate", "the", "role", "of", "carbonic", "anhydrase", "CA", ";", "C1311420#ent", "<e1>", "and", "phosphoenolpyruvate", "carboxylase", "PEPC", ";", "C0042085#ent", "<e2>", "during", "Medicago", "sativa", "seed", "development", "the", "distribution", "of", "both", "proteins", "was", "examined", "using", "an", "immunohistological", "approach", "."], "h": {"id": "C1311420", "name": "C1311420#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042085", "name": "C0042085#ent", "pos": [16, 17]}}
{"token": ["Glucose-induced", "inactivation", "of", "the", "gluconeogenetic", "enzymes", "fructose-1,6-biphosphatase", "cytoplasmic", "malate", "dehydrogenase", "C0251211#ent", "<e1>", "tested", "in", "yeast", "mutants", "defective", "in", "C1382029#ent", "<e2>", "cyr1", "mutation", ")", "and", "in", "the", "cAMP-binding", "subunit", "of", "cAMP-dependent", "protein", "kinase", "bcy", "1", "mutation", ")", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [18, 19]}}
{"token": ["The", "EDDF", "C1517488#ent", "<e1>", "of", "MEDDF", ",", "HEDDF-1", ",", "HEDRF-1", ",", "C3889381#ent", "<e2>", "and", "HCNBP-1", "were", "cloned", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889381", "name": "C3889381#ent", "pos": [11, 12]}}
{"token": ["The", "hemorrhagic", "lesions", "appeared", "to", "be", "induced", "by", "C0010200#ent", "<e1>", "due", "to", "C0149514#ent", "<e2>", "for", "which", "the", "penicillin", "was", "given", "."], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [12, 13]}}
{"token": ["From", "the", "above", "results", ",", "C0015674#ent", "<e1>", "was", "effective", "C1254351#ent", "<e2>", "to", "P.", "aeruginosa", "infections", "by", "intravenous", "administration", "25", "mg/kg", "of", "C0015674#ent", "<e1>", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "C0015674#ent", "<e1>", "is", "considered", "to", "be", "the", "useful", "C1254351#ent", "<e2>", "for", "the", "treatment", "of", "pediatric", "infection", "by", "P.", "aeruginosa"], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}}
{"token": ["The", "fact", "that", "245-HCB", "was", "not", "C0025517#ent", "<e1>", "explains", "why", "it", "is", "the", "predominant", "C1418288#ent", "<e2>", "found", "in", "human", "adipose", "tissue"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418288", "name": "C1418288#ent", "pos": [14, 15]}}
{"token": ["C0961485#ent", "<e1>", ",", "a", "selective", "aldosterone", "blocker", "C3541916#ent", "<e2>", ")", "that", "is", "highly", "specific", "for", "the", "aldosterone", "receptor", "has", "the", "potential", "to", "be", "efficacious", "in", "the", "treatment", "of", "hypertension", "."], "h": {"id": "C0961485", "name": "C0961485#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541916", "name": "C3541916#ent", "pos": [7, 8]}}
{"token": ["In", "C1705998#ent", "<e1>", "animals", ",", "no", "C1704793#ent", "<e2>", "response", "to", "either", "of", "the", "stress", "exposures", "apparent", ";", "in", "spite", "of", "this", ",", "partial", "CS", "responses", "were", "elicited", "."], "h": {"id": "C1705998", "name": "C1705998#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [6, 7]}}
{"token": ["Mutations", "in", "the", "pituitary-specific", "paired-like", "homeodomain", "transcription", "factor", "result", "in", "combined", "pituitary", "hormone", "deficiency", "C1705998#ent", "<e1>", ")", "which", "includes", "all", "anterior", "pituitary", "hormones", "the", "exception", "of", "C1704793#ent", "<e2>", "."], "h": {"id": "C1705998", "name": "C1705998#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [26, 27]}}
{"token": ["We", "conclude", "that", "in", "idiopathic", "C1705998#ent", "<e1>", "patients", ",", "both", "the", "standard", "and", "low-dose", "C1704793#ent", "<e2>", "tests", "are", "equivalent", "to", "IIH", "in", "detecting", "HPA", "insufficiency"], "h": {"id": "C1705998", "name": "C1705998#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [14, 15]}}
{"token": ["Clinical", "studies", "that", "the", "efficacy", "of", "C0700606#ent", "<e1>", "is", "equivalent", "to", "that", "of", "propranolol", "and", "C0280858#ent", "<e2>", "for", "control", "of", "supraventricular", "tachycardia", "to", "sodium", "nitroferricyanide", "sodium", "nitroprusside", "for", "control", "of", "postoperative", "hypertension", "."], "h": {"id": "C0700606", "name": "C0700606#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [15, 16]}}
{"token": ["These", "data", "indicate", "that", "C0472762#ent", "<e1>", "is", "associated", "with", "diminished", "degree", "of", "C0003429#ent", "<e2>", "in", "individuals", "with", "sickle", "cell", "anemia"], "h": {"id": "C0472762", "name": "C0472762#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003429", "name": "C0003429#ent", "pos": [12, 13]}}
{"token": ["We", "found", "a", "much", "higher", "prevalence", "of", "asthmatic", "symptoms", "and", "abnormal", "C0085129#ent", "<e1>", "survivors", "of", "neonatal", "C0025048#ent", "<e2>", "in", "the", "general", "childhood", "population"], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025048", "name": "C0025048#ent", "pos": [16, 17]}}
{"token": ["Spontaneous", "and", "killed", "BCG", "culture-stimulated", "killed", "HCT-test", ",", "the", "activity", "of", "superoxide", "dismutase", "SOD", ")", "and", "C1413138#ent", "<e1>", ",", "the", "level", "of", "malonic", "dialdehyde", "MDA", ")", "and", "platelet", "activation", "factor", "C0235480#ent", "<e2>", ")", "were", "determined", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [30, 31]}}
{"token": ["The", "carbazole-degradative", "plasmid", "was", "isolated", "from", "Pseudomonas", "putida", "had", "a", "C1136352#ent", "<e1>", "to", "that", "of", "C1413136#ent", "<e2>", ",", "the", "IncP-7", "archetype", "plasmid", "."], "h": {"id": "C1136352", "name": "C1136352#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413136", "name": "C1413136#ent", "pos": [15, 16]}}
{"token": ["Such", "beta-aggregation", "is", "typical", "of", "C0268407#ent", "<e1>", "include", "Alzheimer's", "Parkinson's", "and", "C0011860#ent", "<e2>", "well", "as", "the", "spongiform", "encephalopathies"], "h": {"id": "C0268407", "name": "C0268407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [11, 12]}}
{"token": ["It", "seems", "that", "analysis", "has", "been", "well", "grounded", "in", "most", "cases", "and", "helps", "to", "establish", "diagnosis", "in", "many", "C0035242#ent", "<e1>", "in", "unexplained", "liver", "cirrhosis", "even", "in", "C0003496#ent", "<e2>"], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003496", "name": "C0003496#ent", "pos": [26, 27]}}
{"token": ["Placentas", "from", "the", "C0038644#ent", "<e1>", "victims", "had", "an", "increased", "frequency", "of", "C1275592#ent", "<e2>", "acute", "chorioamnionitis", "lymphocytic", "infiltration", "the", "decidua", "and", "macrophages", "in", "the", "fetal", "membranes"], "h": {"id": "C0038644", "name": "C0038644#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1275592", "name": "C1275592#ent", "pos": [11, 12]}}
{"token": ["One", "way", "to", "improve", "the", "C1705504#ent", "<e1>", "geometry", "is", "to", "attach", "carbon", "nanotubes", "C3272518#ent", "<e2>", ")", "to", "AFM", "tips", "."], "h": {"id": "C1705504", "name": "C1705504#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3272518", "name": "C3272518#ent", "pos": [13, 14]}}
{"token": ["C1425074#ent", "<e1>", "is", "a", "highly", "abundant", ",", "ubiquitous", "protein", "with", "C0536221#ent", "<e2>", "the", "regulation", "of", "lipid", "metabolism", "transport", "."], "h": {"id": "C1425074", "name": "C1425074#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [10, 11]}}
{"token": ["Overall", ",", "these", "results", "indicate", "that", "a", "predictable", "transition", "from", "3", "mg", "intravenous", "to", "oral", "doses", "C0006376#ent", "<e1>", "is", "possible", "in", "C0018802#ent", "<e2>", "."], "h": {"id": "C0006376", "name": "C0006376#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["C0006376#ent", "<e1>", "has", "demonstrated", "efficacy", "in", "the", "management", "of", "edema", "associated", "with", "C0018802#ent", "<e2>", "hepatic", "cirrhosis", "and", "renal", "insufficiency"], "h": {"id": "C0006376", "name": "C0006376#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}}
{"token": ["Our", "findings", "indicate", "that", "adenoma", "in", "the", "common", "bile", "duct", "pancreatic", "duct", "be", "considered", "as", "a", "possible", "etiology", "when", "patients", "with", "familial", "polyposis", "C0017097#ent", "<e1>", "with", "pancreatitis", ",", "particularly", "relapsing", "C0030305#ent", "<e2>"], "h": {"id": "C0017097", "name": "C0017097#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [30, 31]}}
{"token": ["We", "report", "the", "case", "of", "a", "41-year-old", "woman", "with", "the", "C0017097#ent", "<e1>", "whom", "relapsing", "C0030305#ent", "<e2>", "the", "presenting", "manifestation", "of", "an", "ampullary", "neoplasm"], "h": {"id": "C0017097", "name": "C0017097#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [14, 15]}}
{"token": ["Upon", "induction", "of", "apoptosis", "in", "thymocytes", ",", "transient", "C0080054#ent", "<e1>", "activation", "was", "detected", "prior", "to", "lamina", "breakdown", "and", "C0597094#ent", "<e2>"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0597094", "name": "C0597094#ent", "pos": [18, 19]}}
{"token": ["Further", "studies", "demonstrated", "that", "the", "fibrosarcoma", "C0003486#ent", "<e1>", "involved", "in", "in", "vitro", "induction", "of", "C3272447#ent", "<e2>", "were", "not", "present", "on", "normal", "adult", "foetal", "tissues"], "h": {"id": "C0003486", "name": "C0003486#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3272447", "name": "C3272447#ent", "pos": [14, 15]}}
{"token": ["2-Chloroethyl", "nitrosocarbamoylcystamine", "or", "ICIG-1325", "(", "C0067288#ent", "<e1>", ")", "is", "a", "lipid-soluble", "isomeric", "mixture", "of", "C3540781#ent", "<e2>", "."], "h": {"id": "C0067288", "name": "C0067288#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540781", "name": "C3540781#ent", "pos": [14, 15]}}
{"token": ["In", "the", "C1826261#ent", "<e1>", "recording", ",", "the", "middle-latency", "components", "(", "N140", "and", "C0069879#ent", "<e2>", ")", "were", "identified", "as", "being", "maximal", "around", "the", "vertex", "."], "h": {"id": "C1826261", "name": "C1826261#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0069879", "name": "C0069879#ent", "pos": [12, 13]}}
{"token": ["Expression", "of", "DNA-PKcs", "and", "C1823878#ent", "<e1>", "after", "irradiation", "was", "increased", "in", "the", "C1332416#ent", "<e2>", "cells", "of", "OSCC", "tissues", "irradiated", "preoperatively", "."], "h": {"id": "C1823878", "name": "C1823878#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [12, 13]}}
{"token": ["To", "investigate", "the", "evolution", "of", "C0035086#ent", "<e1>", "patients", "on", "maintenance", "dialysis", "treated", "with", "C0768119#ent", "<e2>", "LC", ")", "vs.", "standard", "phosphate-binder", "therapy", "(", "Stx", ")", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0768119", "name": "C0768119#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "the", "anti-apoptotic", "stimulus", ",", "C1367721#ent", "<e1>", "EGF", ")", ",", "fails", "to", "increase", "C1336644#ent", "<e2>", "expression", "but", "effectively", "activates", "NF-kappaB", "and", "induces", "p65", "binding", "to", "the", "DR5", "gene", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336644", "name": "C1336644#ent", "pos": [15, 16]}}
{"token": ["This", "portion", "of", "Ras-GRF", "accelerated", "the", "release", "of", "GDP", "from", "C0015230#ent", "<e1>", "and", "RasN", "p21", "in", "vitro", "but", "not", "from", "the", "related", "C1455060#ent", "<e2>", ",", "or", "CDC42Hs", "GTP-binding", "proteins"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1455060", "name": "C1455060#ent", "pos": [22, 23]}}
{"token": ["A", "literature", "review", "the", "spectrum", "of", "differential", "diagnosis", "patients", "with", "livedo", "reticularis", "especially", "C0263401#ent", "<e1>", "amantadine-induced", "livedo", "reticularis", ")", "and", "livedo", "racemosa", "especially", "Sneddon's", "syndrome", "C1859783#ent", "<e2>", "systemic", "lupus", "erythematosus", "antiphospholipid", "antibody", "syndrome", "polyarteritis", "nodosa", "cholesterol", "embolization", "syndrome", "livedoid", "vasculopathy", "haematological", "diseases", "is", "provided", "."], "h": {"id": "C0263401", "name": "C0263401#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C1859783", "name": "C1859783#ent", "pos": [25, 26]}}
{"token": ["I", "have", "used", "talc", "in", "patients", "with", "C0080032#ent", "<e1>", "recurrent", "pneumothorax", ",", "chylothorax", "and", "in", "selected", "cases", "of", "C0014013#ent", "<e2>", "."], "h": {"id": "C0080032", "name": "C0080032#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014013", "name": "C0014013#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "hydrogen", "peroxide-dependent", "oxidation", "of", "six", "phenothiazines", "by", "purified", "C0023837#ent", "<e1>", "from", "soybean", "(", "C1416602#ent", "<e2>", ")", "and", "human", "term", "placenta", "(", "HTPLO", ")", "."], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1416602", "name": "C1416602#ent", "pos": [19, 20]}}
{"token": ["4-Coumarate", ":", "C0023689#ent", "<e1>", "4CL", ")", ",", "a", "key", "C0014442#ent", "<e2>", "of", "phenylpropanoid", "metabolism", "plants", ",", "is", "encoded", "in", "potato", "(", "Solanum", "tuberosum", "L.", "by", "two", "structurally", "similar", "genes", "(", "St4cl-1", ",", "St4cl-2", ")", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["The", "2',5'-oligoadenylate", "(", "2", "-", "5A", ")", "C0023689#ent", "<e1>", "is", "an", "intracellular", "C0014442#ent", "<e2>", "induced", "by", "interferon", "(", "IFN", ")", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["AGE", "inhibitors", "or", "breakers", ",", "such", "as", "aminoguanidine", "or", "C3537001#ent", "<e1>", ",", "inhibit", "the", "age-induced", "heart", "hypertrophy", "C0427008#ent", "<e2>", "of", "the", "large", "arteries", "."], "h": {"id": "C3537001", "name": "C3537001#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0427008", "name": "C0427008#ent", "pos": [17, 18]}}
{"token": ["The", "clinical", "features", "and", "history", "of", "the", "disease", "create", "difficulties", "in", "differential", "diagnosis", "with", "C0024025#ent", "<e1>", "caused", "by", "infectious", "agents", "with", "C0035309#ent", "<e2>", "other", "demyelinating", "syndromes", "vasculitis", ",", "nonvasculitic", "autoimmune", "encephalopathies", "."], "h": {"id": "C0024025", "name": "C0024025#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035309", "name": "C0035309#ent", "pos": [21, 22]}}
{"token": ["Macrophage", "migration", "inhibitory", "factor", "MIF", ")", ",", "an", "important", "cytokine", "released", "in", "sepsis", "and", "the", "C0035220#ent", "<e1>", "is", "a", "known", "C0027048#ent", "<e2>"], "h": {"id": "C0035220", "name": "C0035220#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027048", "name": "C0027048#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "exposure", "to", "caused", "a", "transcription", "dependent", "induction", "of", "C0020239#ent", "<e1>", "might", "compensate", "for", "the", "C0027203#ent", "<e2>", "inhibition", "by", "lead", "."], "h": {"id": "C0020239", "name": "C0020239#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "T-cell", "receptor", "gene", "rearrangement", "C0037284#ent", "<e1>", "peripheral", "blood", "6", "patients", "with", "adult", "T-cell", "leukemia", "C0054871#ent", "<e2>", ")", "using", "the", "Southern", "blot", "method", "a", "c", "beta", "1", "probe"], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [16, 17]}}
{"token": ["In", "this", "case", ",", "only", "gene", "analysis", "the", "C0037284#ent", "<e1>", "facilitate", "making", "an", "early", "differential", "diagnosis", "of", "C0054871#ent", "<e2>", "from", "other", "lymphoproliferative", "diseases", "including", "nonviral", "cutaneous", "T-cell", "lymphoma", "benign", "lymphoid", "hyperplasia"], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [17, 18]}}
{"token": ["A", "54-year-old", "woman", "with", "leucocytosis", "and", "C0037284#ent", "<e1>", "hospitalized", "and", "diagnosed", "as", "chronic", "type", "adult", "T", "cell", "leukemia", "C0054871#ent", "<e2>", ")", "in", "August", "1989", "."], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [18, 19]}}
{"token": ["C0164790#ent", "<e1>", "not", "significantly", "affect", "measures", "of", "glucocorticoid", "activity", "blood", "glucose", "C1337111#ent", "<e2>", "cortisol", ",", "eosinophil", ",", "or", "lymphocyte", "levels", "."], "h": {"id": "C0164790", "name": "C0164790#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [11, 12]}}
{"token": ["However", ",", "Western", "blots", "that", "the", "induction", "of", "Elk-1-regulated", "expression", "of", "endogenous", "C0087140#ent", "<e1>", "was", "not", "affected", "by", "C3890185#ent", "<e2>", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3890185", "name": "C3890185#ent", "pos": [18, 19]}}
{"token": ["C0671566#ent", "<e1>", "reconstituted", "with", "such", "porphyrins", "required", "higher", "concentrations", "of", "C0072497#ent", "<e2>", "further", "activation", "and", "were", "not", "activated", "by", "NO", "."], "h": {"id": "C0671566", "name": "C0671566#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072497", "name": "C0072497#ent", "pos": [10, 11]}}
{"token": ["The", "sulphonamide-derived", "oral", "antidiabetic", "drugs", ",", "chlorpropamide", ",", "glibenclamide", ",", "glibornuride", ",", "gliclazide", ",", "glipizide", ",", "gliquidone", ",", "C0061330#ent", "<e1>", ",", "glymidine", ",", "tolazamide", "and", "C0724709#ent", "<e2>", "were", "investigated", "for", "photohemolytic", "properties", "in", "vitro"], "h": {"id": "C0061330", "name": "C0061330#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [25, 26]}}
{"token": ["After", "liquid-liquid", "extraction", "the", "OADs", "glibenclamide", ",", "glibornuride", ",", "gliclazide", ",", "glimepiride", ",", "glipizide", ",", "gliquidone", ",", "C0061330#ent", "<e1>", ",", "tolazamide", "and", "C0724709#ent", "<e2>", "were", "separated", "using", "fast", "gradient", "elution", "."], "h": {"id": "C0061330", "name": "C0061330#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [22, 23]}}
{"token": ["Mutations", "of", "the", "HFE", "gene", "cause", "C0392514#ent", "<e1>", "be", "associated", "with", "increased", "risk", "of", "C0007222#ent", "<e2>"], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "these", "results", "suggest", "that", "the", "plasma", "membrane", "localization", "of", "C1334470#ent", "<e1>", "by", "C1539796#ent", "<e2>", "requires", "the", "C2", "domain", "C1539796#ent", "<e2>", "and", "is", "essential", "for", "the", "inhibitory", "effect", "of", "C1334470#ent", "<e1>", "in", "the", "transforming", "growth", "factor-beta", "signaling", "pathway"], "h": {"id": "C1539796", "name": "C1539796#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334470", "name": "C1334470#ent", "pos": [11, 12]}}
{"token": ["Smad", "ubiquitin", "regulatory", "factor", "1", "C1539796#ent", "<e1>", ")", ",", "a", "HECT-type", "E3", "ubiquitin", "ligase", "interacts", "with", "inhibitory", "C1334470#ent", "<e2>", "and", "induces", "cytoplasmic", "localization", "C1334470#ent", "<e2>", "."], "h": {"id": "C1539796", "name": "C1539796#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334470", "name": "C1334470#ent", "pos": [17, 18]}}
{"token": ["C0009324#ent", "<e1>", "despite", "discontinuation", "of", "interferon", "beta", "1a", "treatment", "and", "C0017373#ent", "<e2>", "the", "patient", "to", "glatiramer", "acetate"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017373", "name": "C0017373#ent", "pos": [10, 11]}}
{"token": ["C0886927#ent", "<e1>", "weakly", "inhibited", "C0037956#ent", "<e2>", "binding", "in", "both", "pituitary", "and", "striatal", "membranes", "affinity", "5", "-", "7", "times", "lower", "than", "sulpiride", "and", "400", "-", "300", "times", "lower", "than", "haloperidol", "."], "h": {"id": "C0886927", "name": "C0886927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037956", "name": "C0037956#ent", "pos": [4, 5]}}
{"token": ["To", "investigate", "the", "effects", "of", "two", "antioxidants", "on", "the", "alterations", "of", "nuclear", "factor", "kappaB", "NF-kappaB", ")", "activity", "and", "p65", ",", "p50", "protein", "expression", "and", "phosphorylation", "of", "C1334877#ent", "<e1>", "in", "rat", "hippocampus", "following", "C0007786#ent", "<e2>"], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0007786", "name": "C0007786#ent", "pos": [32, 33]}}
{"token": ["Finally", ",", "C0672708#ent", "<e1>", "and", "RT-PCR", "showed", "expression", "of", "the", "C1332123#ent", "<e2>", "the", "rat", "and", "human", "hippocampi", "as", "well", "."], "h": {"id": "C0672708", "name": "C0672708#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332123", "name": "C1332123#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "cell", "adhesion", "C3889469#ent", "<e1>", "was", "independent", "of", "the", "level", "of", "C0297349#ent", "<e2>", "expression", "of", "the", "plated", "cells"], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0297349", "name": "C0297349#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "vegetative", "and", "C0037317#ent", "<e1>", "been", "described", "in", "both", "C0242422#ent", "<e2>", "patients", "and", "in", "MPTP", "chronic", "monkeys", ";", "these", "may", "result", "indirectly", "from", "concomitant", "hormonal", "variations", "."], "h": {"id": "C0037317", "name": "C0037317#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [10, 11]}}
{"token": ["The", "76", "bp", "sequence", "found", "in", "the", "upstream", "region", "a", "gene", "for", "26S", "rRNA", "rrn26", ")", "is", "duplicated", "in", "the", "upstream", "region", "a", "gene", "for", "C1421159#ent", "<e1>", "trnfM", ")", "in", "the", "C1563761#ent", "<e2>", "rice", "."], "h": {"id": "C1421159", "name": "C1421159#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1563761", "name": "C1563761#ent", "pos": [31, 32]}}
{"token": ["Two", "C1421159#ent", "<e1>", "tRNA", ")", "genes", "were", "identified", "in", "the", "maize", "C1563761#ent", "<e2>", "nucleotide", "sequence", "analysis"], "h": {"id": "C1421159", "name": "C1421159#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1563761", "name": "C1563761#ent", "pos": [11, 12]}}
{"token": ["C0075193#ent", "<e1>", "did", "not", "inhibit", "1,25-(OH)2D3", "induction", "of", "nonspecific", "C1257646#ent", "<e2>", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [9, 10]}}
{"token": ["Smooth", "muscle", "cell", "C3888088#ent", "<e1>", ")", "plays", "critical", "roles", "in", "many", "C0012634#ent", "<e2>", "an", "in", "vitro", "system", "recapitulates", "human", "C3888088#ent", "<e1>", "differentiation", "would", "be", "invaluable", "for", "exploring", "molecular", "mechanisms", "to", "the", "C0012634#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [3, 4]}}
{"token": ["Diabetes", "mellitus", "a", "common", "disease", "among", "patients", "with", "pancreatic", "cancer", "C0149521#ent", "<e1>", "disorders", "of", "the", "C0700138#ent", "<e2>"], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0700138", "name": "C0700138#ent", "pos": [15, 16]}}
{"token": ["C0149521#ent", "<e1>", "a", "painful", "chronic", "inflammatory", "disease", "the", "C0700138#ent", "<e2>", "is", "associated", "with", "replacement", "of", "functional", "parenchyma", "by", "extended", "fibrosis", "and", "with", "a", "massive", "infiltration", "of", "T", "lymphocytes"], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0700138", "name": "C0700138#ent", "pos": [8, 9]}}
{"token": ["The", "possibility", "of", "the", "sequential", "release", "of", "acid-insoluble", "intermediate", "fragments", "as", "well", "as", "C1412739#ent", "<e1>", "the", "terminal", "portion", "DNA", "by", "the", "C0014442#ent", "<e2>", "is", "discussed", "."], "h": {"id": "C1412739", "name": "C1412739#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["30", "min", "after", "the", "injection", "about", "10", "%", "of", "the", "injected", "radioactivity", "was", "present", "in", "C1412739#ent", "<e1>", "blood", ",", "indicating", "that", "the", "C0014442#ent", "<e2>", "had", "been", "rapidly", "degraded", "."], "h": {"id": "C1412739", "name": "C1412739#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "the", "C0671924#ent", "<e1>", "Gcn5", "and", "Esa1", "and", "the", "histone", "deacetylases", "Rpd3", "C2699247#ent", "<e2>", ",", "and", "Hst1", "are", "recruited", "to", "the", "HO", "lesion", "during", "homologous", "recombinational", "repair"], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2699247", "name": "C2699247#ent", "pos": [13, 14]}}
{"token": ["50", "patients", "with", "different", "types", "of", "C0020476#ent", "<e1>", "were", "treated", "with", "combination", "of", "C0009002#ent", "<e2>", "(", "700", "mg", ")", "and", "mesoinositol-hexanicotinate", "(", "500", "mg", ")", "(", "Atroplex", ")", "twice", "daily", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [13, 14]}}
{"token": ["These", "observations", "lead", "to", "a", "hypothesis", "that", "C1334894#ent", "<e1>", "is", "involved", "in", "structural", "changes", "C0008546#ent", "<e2>", ",", "thereby", "regulating", "transcription", "and", "replication", "within", "the", "ribosomal", "DNA", "region", "maintaining", "the", "nucleolar", "structure"], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [14, 15]}}
{"token": ["C1334894#ent", "<e1>", "dispersed", "in", "the", "C0008546#ent", "<e2>", "and", "was", "not", "accumulated", "in", "the", "nucleoli", "."], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [5, 6]}}
{"token": ["Neisseria", "meningitidis", "a", "causative", "agent", "C0025297#ent", "<e1>", "obtains", "transferrin-bound", "iron", "by", "expressing", "two", "outer", "membrane", "transferrin-binding", "proteins", "C1421224#ent", "<e2>", "and", "TbpB.", "C1421224#ent", "<e2>", "is", "thought", "to", "be", "an", "integral", "outer", "membrane", "pore", "facilitates", "iron", "uptake"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421224", "name": "C1421224#ent", "pos": [17, 18]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "report", "the", "diagnosis", "and", "management", "of", "entrapment", "C0021847#ent", "<e1>", "of", "the", "lateral", "antebrachial", "cutaneous", "nerve", "LABCN", ")", "presenting", "as", "C0239266#ent", "<e2>"], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0239266", "name": "C0239266#ent", "pos": [26, 27]}}
{"token": ["They", "find", "that", "C1427812#ent", "<e1>", "stimulates", "the", "processing", "of", "p100", "to", "C1335821#ent", "<e2>", "NF-kappaB.", "Moreover", ",", "nuclear", "p52", "is", "also", "associated", "with", "C1427812#ent", "<e1>", "expression", "in", "tumor", "tissue", "biopsies"], "h": {"id": "C1335821", "name": "C1335821#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1427812", "name": "C1427812#ent", "pos": [3, 4]}}
{"token": ["Npt2a", "expression", "was", "not", "affected", "by", "the", "phosphate", "content", "of", "the", "media", "in", "C3810600#ent", "<e1>", "null", "cells", "low", "phosphate", "media", "up-regulated", "C1418448#ent", "<e2>", "abundance", "."], "h": {"id": "C3810600", "name": "C3810600#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418448", "name": "C1418448#ent", "pos": [21, 22]}}
{"token": ["Na(+)/H(+)", "C3810600#ent", "<e1>", "is", "a", "C1418448#ent", "<e2>", "to", "bind", "to", "various", "receptors", ",", "channels", ",", "cytoskeletal", "elements", "and", "cytoplasmic", "signaling", "proteins"], "h": {"id": "C3810600", "name": "C3810600#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418448", "name": "C1418448#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "photoaging", "increased", "the", "UV", "inducibility", "of", "C0087140#ent", "<e1>", "but", "decreased", "the", "baseline", "expression", "of", "the", "differentiation-associated", "genes", "IL-1", "receptor", "antagonist", "C3273781#ent", "<e2>", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273781", "name": "C3273781#ent", "pos": [23, 24]}}
{"token": ["The", "N363S", "polymorphism", "of", "the", "C1705401#ent", "<e1>", "results", "in", "an", "asparagine", "to", "C0815040#ent", "<e2>", "substitution", "in", "a", "modulatory", "region", "the", "receptor", "."], "h": {"id": "C1705401", "name": "C1705401#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [12, 13]}}
{"token": ["Also", "discussed", "are", "sinonasal", ",", "neurologic", ",", "and", "endocrine", "complications", ",", "which", "may", "include", "bleeding", ",", "sinusitis", ",", "and", "C0154933#ent", "<e1>", ";", "cerebrospinal", "fluid", "leaks", "bleeding", ";", "and", "C0011848#ent", "<e2>", "panhypopituitarism", ",", "respectively", "."], "h": {"id": "C0154933", "name": "C0154933#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [28, 29]}}
{"token": ["C0282331#ent", "<e1>", "and", "related", "9-aminoacridine", "compounds", "effective", "in", "eliminating", "the", "alternatively", "C4082486#ent", "<e2>", "termed", "PrP(Sc", ")", ",", "from", "scrapie-infected", "cultured", "cells"], "h": {"id": "C0282331", "name": "C0282331#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [11, 12]}}
{"token": ["In", "a", "prior", "study", "of", "the", "genetic", "basis", "schizophrenia", ",", "we", "showed", "that", "exonic", "polymorphisms", "C3273878#ent", "<e1>", "were", "associated", "with", "increased", "risk", "of", "schizophrenia", "and", "C3665349#ent", "<e2>", "in", "a", "large", "cohort", "of", "probands", "from", "New", "York"], "h": {"id": "C3273878", "name": "C3273878#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [25, 26]}}
{"token": ["The", "efficacy", "of", "C0076829#ent", "<e1>", "was", "demonstrated", "in", "C0014547#ent", "<e2>", "but", "the", "other", "indications", "remain", "to", "be", "pr\u00e9cised", "."], "h": {"id": "C0076829", "name": "C0076829#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [8, 9]}}
{"token": ["C0796516#ent", "<e1>", "pi", "was", "the", "predominant", "class", "in", "both", "the", "C0277565#ent", "<e2>", "and", "normal", "buccal", "mucosa", "."], "h": {"id": "C0796516", "name": "C0796516#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [10, 11]}}
{"token": ["Because", "the", "substrate", "specificity", "of", "Pgp", "and", "CYP3A", "overlap", ",", "the", "effect", "of", "C0380527#ent", "<e1>", "on", "the", "1'-hydroxylation", "of", "midazolam", "by", "CYP3A", "in", "human", "C0023899#ent", "<e2>", "microsomes", "was", "examined", "."], "h": {"id": "C0380527", "name": "C0380527#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [24, 25]}}
{"token": ["MATa", "preferentially", "recombines", "with", "C4049597#ent", "<e1>", "near", "the", "left", "telomere", "of", "chromosome", "III", "whereas", "MATalpha", "prefers", "C1367453#ent", "<e2>", "near", "the", "right", "telomere", "."], "h": {"id": "C4049597", "name": "C4049597#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367453", "name": "C1367453#ent", "pos": [16, 17]}}
{"token": ["The", "participation", "of", "TNFalpha", ",", "C1363984#ent", "<e1>", ",", "TNFR2", "and", "Fas", "in", "the", "inhibition", "of", "C1366909#ent", "<e2>", "expression", "was", "also", "demonstrated", "."], "h": {"id": "C1363984", "name": "C1363984#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366909", "name": "C1366909#ent", "pos": [15, 16]}}
{"token": ["Total", "parenteral", "nutrition", "C1420583#ent", "<e1>", ")", "was", "given", "with", "nonprotein", "energy", "entirely", "as", "C0017740#ent", "<e2>", "glucose", "system", "or", "as", "half", "glucose-half", "intravenous", "fat", "emulsion", "lipid", "system", "."], "h": {"id": "C1420583", "name": "C1420583#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017740", "name": "C0017740#ent", "pos": [13, 14]}}
{"token": ["The", "values", "of", "PGf2", "alpha", "studied", "in", "20", "renal", "patients", "with", "C0020544#ent", "<e1>", "with", "and", "without", "C1561643#ent", "<e2>", "a", "radioimmunologic", "method", "."], "h": {"id": "C0020544", "name": "C0020544#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [16, 17]}}
{"token": ["Suppressed", "PRA", "was", "proved", "also", "in", "20.9", "%", "of", "patients", "with", "C0020544#ent", "<e1>", "in", "34.4", "%", "of", "patients", "with", "hypertension", "in", "C1561643#ent", "<e2>"], "h": {"id": "C0020544", "name": "C0020544#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [21, 22]}}
{"token": ["The", "determination", "of", "C0033448#ent", "<e1>", "urine", "and", "plasma", "after", "administration", "of", "C0033448#ent", "<e1>", "man", "is", "described", "."], "h": {"id": "C0033448", "name": "C0033448#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033448", "name": "C0033448#ent", "pos": [3, 4]}}
{"token": ["There", "was", "no", "obvious", "difference", "between", "AII-R", "and", "AII-U", "C1414406#ent", "<e1>", "in", "terms", "of", "C0001622#ent", "<e2>"], "h": {"id": "C1414406", "name": "C1414406#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [14, 15]}}
{"token": ["A", "senile", "patient", "showed", "a", "dramatic", "recovery", "from", "medication-resistant", "depression", "after", "non-convulsive", "electroshock", "therapy", "nc-EST", ")", ",", "with", "a", "lasting", "change", "in", "response", "to", "C0040805#ent", "<e1>", ",", "which", "mainly", "acts", "as", "a", "C0162758#ent", "<e2>"], "h": {"id": "C0040805", "name": "C0040805#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [32, 33]}}
{"token": ["Early", "human", "pharmaco-EEG", "and", "subsequent", "sleep", "laboratory", "studies", "C0040805#ent", "<e1>", ",", "a", "5-HT(2", ")", "antagonist", "and", "C0162758#ent", "<e2>", "SARI", ")", ",", "as", "an", "antidepressant", "with", "therapeutic", "effects", "its", "target", "symptoms", "depressed", "mood", "anxiety", "and", "insomnia", "."], "h": {"id": "C0040805", "name": "C0040805#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [16, 17]}}
{"token": ["Once", "lactation", "began", ",", "reductase", ",", "cholesterol", "acyltransferase", "7alpha-hydroxylase", "activities", ",", "low", "density", "lipoprotein", "receptors", "and", "C4084872#ent", "<e1>", "increased", "while", "C3540050#ent", "<e2>", "decreased", "."], "h": {"id": "C4084872", "name": "C4084872#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540050", "name": "C3540050#ent", "pos": [20, 21]}}
{"token": ["Using", "a", "2", "+", "2", "assay", "design", ",", "experiments", "with", "C0106169#ent", "<e1>", "showed", "that", "the", "H2-receptor", "antagonists", "metiamide", "and", "C0008783#ent", "<e2>", "(", "1", "mM", ")", "were", "devoid", "of", "antimuscarinic", "activity"], "h": {"id": "C0106169", "name": "C0106169#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [19, 20]}}
{"token": ["The", "human", "C0314619#ent", "<e1>", "IGL", ")", "is", "mapped", "at", "C0220704#ent", "<e2>", "spanning", "about", "1", "Mb", "of", "DNA", ",", "and", "directs", "the", "synthesis", "of", "lambda-type", "immunoglobulin", "light", "chains"], "h": {"id": "C0314619", "name": "C0314619#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220704", "name": "C0220704#ent", "pos": [9, 10]}}
{"token": ["Poor", "nutrition", "overweight", "and", "obesity", "have", "increasingly", "become", "a", "public", "health", "as", "they", "affect", "many", "C0025517#ent", "<e1>", "including", "heart", "disease", "diabetes", ",", "C0017178#ent", "<e2>", "and", "renal", "failure"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "Na+", "currents", "not", "detected", ",", "but", "C1413043#ent", "<e1>", "+", "currents", "were", "present", "in", "cells", "isolated", "with", "C0030346#ent", "<e2>", "and", "collagenase", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030346", "name": "C0030346#ent", "pos": [19, 20]}}
{"token": ["Glycosyl-trehaloses", "with", "an", "isomaltosyl", "residue", "were", "synthesized", "by", "C1417132#ent", "<e1>", "from", "Aspergillus", "niger", "using", "C0065615#ent", "<e2>", "as", "a", "glucosyl", "donor", "and", "trehalose", "as", "the", "acceptor", "."], "h": {"id": "C1417132", "name": "C1417132#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0065615", "name": "C0065615#ent", "pos": [14, 15]}}
{"token": ["To", "evaluate", "corneal", "surface", "regularity", "and", "the", "effect", "of", "C0003921#ent", "<e1>", "the", "regularity", "of", "the", "corneal", "surface", "in", "C0013238#ent", "<e2>"], "h": {"id": "C0003921", "name": "C0003921#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013238", "name": "C0013238#ent", "pos": [18, 19]}}
{"token": ["The", "five", "groups", "were", "cerebral", "childhood", "adolescent", ",", "pure", "adrenomyeloneuropathy", "pure", "C1527231#ent", "<e1>", ")", ",", "adrenomyeloneuropathy", "cerebral", "C1527231#ent", "<e1>", "cerebral", ")", ",", "C2103602#ent", "<e1>", "and", "symptomatic", "female", "heterozygotes", "."], "h": {"id": "C1527231", "name": "C1527231#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2103602", "name": "C2103602#ent", "pos": [22, 23]}}
{"token": ["A", "family", "is", "reported", "in", "which", "there", "is", "one", "case", "of", "C1527231#ent", "<e1>", ",", "one", "case", "of", "C2103602#ent", "<e2>", "at", "least", "three", "heterozygous", "females", "with", "spastic", "paraparesis", "peripheral", "neuropathy"], "h": {"id": "C1527231", "name": "C1527231#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2103602", "name": "C2103602#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "the", "possibility", "of", "C1527231#ent", "<e1>", "should", "be", "considered", "in", "any", "boy", "with", "C2103602#ent", "<e2>"], "h": {"id": "C1527231", "name": "C1527231#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2103602", "name": "C2103602#ent", "pos": [15, 16]}}
{"token": ["Because", "it", "has", "a", "long", "duration", "of", "action", ",", "C0050940#ent", "<e1>", "can", "be", "used", "to", "control", "gastric", "acid", "hypersecretion", "most", "patients", "with", "C0043515#ent", "<e2>", "a", "once", "daily", "dosing", "schedule", "."], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [22, 23]}}
{"token": ["The", "long-term", "safety", "and", "efficacy", "of", "C0050940#ent", "<e1>", "were", "studied", "in", "21", "patients", "with", "C0043515#ent", "<e2>"], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "prospective", "study", "to", "confirm", "the", "efficacy", "and", "safety", "of", "C0050940#ent", "<e1>", "in", "patients", "with", "C0043515#ent", "<e2>", "ZES", ")", "."], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [18, 19]}}
{"token": ["C2347318#ent", "<e1>", "is", "found", "to", "share", "overall", "structural", "similarity", "with", "the", "C0068842#ent", "<e2>", "including", "the", "subunit", "bridging", "[", "4Fe-4S", "]", "cluster", "and", "nucleotide", "binding", "sites"], "h": {"id": "C2347318", "name": "C2347318#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0068842", "name": "C0068842#ent", "pos": [11, 12]}}
{"token": ["The", "LTD", "or", "LTP", "induced", "in", "the", "presence", "of", "insulin", "was", "N-methyl-d-aspartate", "(", "NMDA", ")", "receptor", "specific", "as", "it", "could", "be", "inhibited", "by", "alpha-amino-5-phosphonopentanoic", "acid", "C0754188#ent", "<e1>", ")", ",", "a", "specific", "C3536824#ent", "<e2>"], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C3536824", "name": "C3536824#ent", "pos": [31, 32]}}
{"token": ["The", "postsynaptic", "field", "potential", "suppressed", "by", "6-cyano-7-nitroquinoxaline-2,3-dione", "(", "CNQX", ")", ",", "a", "non-NMDA", "receptor", "antagonist", ",", "in", "a", "concentration-dependent", "manner", ",", "but", "not", "affected", "by", "D-amino-5-phosphonovaleric", "acid", "C0754188#ent", "<e1>", ")", ",", "a", "competitive", "C3536824#ent", "<e2>"], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C3536824", "name": "C3536824#ent", "pos": [33, 34]}}
{"token": ["In", "this", "study", ",", "the", "case", "has", "been", "reported", "of", "a", "left", "renocolic", "fistula", "that", "was", "detected", "in", "a", "patient", "with", "C0019196#ent", "<e1>", "cirrhotic", "complications", "who", "was", "hospitalized", "for", "C0041333#ent", "<e2>"], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0041333", "name": "C0041333#ent", "pos": [29, 30]}}
{"token": ["After", "the", "washout", "period", ",", "animals", "were", "then", "re-challenged", "with", "C0813872#ent", "<e1>", "to", "determine", "whether", "C0080356#ent", "<e2>", "disrupted", "the", "behavioral", "sensitization", "elicited", "by", "C0813872#ent", "<e1>", "."], "h": {"id": "C0813872", "name": "C0813872#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080356", "name": "C0080356#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "C0813872#ent", "<e1>", "potentiated", "the", "adverse", "effects", "not", "the", "anticonvulsant", "activity", "50", "mg/kg", "C0080356#ent", "<e2>", "."], "h": {"id": "C0813872", "name": "C0813872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0080356", "name": "C0080356#ent", "pos": [14, 15]}}
{"token": ["C0531026#ent", "<e1>", "encodes", "for", "C1335796#ent", "<e2>", ",", "a", "multidrug", "resistant", "protein", "expressed", "in", "the", "liver", "and", "kidney", "."], "h": {"id": "C0531026", "name": "C0531026#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335796", "name": "C1335796#ent", "pos": [4, 5]}}
{"token": ["The", "protein/DNA", "ratio", ",", "a", "marker", "of", "cellular", "hypertrophy", "was", "increased", "by", "C0271725#ent", "<e1>", "in", "the", "G1", "and", "C1414052#ent", "<e2>", "rats", "drinking", "respectively", "the", "NaCl", "or", "the", "KCl", "solutions", "."], "h": {"id": "C0271725", "name": "C0271725#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [18, 19]}}
{"token": ["We", "studied", "sera", "from", "patients", "with", "various", "disorders", "including", "collagen", "diseases", "C0040021#ent", "<e1>", "deep", "vein", "thrombosis", "repeated", "abortions", "and", "C0398650#ent", "<e2>", "order", "to", "measure", "anticardiolipin", "antibody", "aCL", ")", "titers", "."], "h": {"id": "C0040021", "name": "C0040021#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0398650", "name": "C0398650#ent", "pos": [19, 20]}}
{"token": ["Malaria", ",", "C0041234#ent", "<e1>", "Trypanosoma", "cruzi/Chagas", "disease", ")", "and", "C0033740#ent", "<e2>", "e.g.", "Babesia", ")", "can", "be", "efficiently", "transmitted", "by", "transfusion", "of", "cellular", "blood", "components"], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0033740", "name": "C0033740#ent", "pos": [9, 10]}}
{"token": ["The", "findings", "in", "manual", "muscle", "tests", "functional", "activity", "a", "beneficial", "trend", "with", "chronic", "C0282138#ent", "<e1>", "treatment", "in", "C0013264#ent", "<e2>", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013264", "name": "C0013264#ent", "pos": [17, 18]}}
{"token": ["Concentrations", "of", "aqueous", "humor", "endothelin", "are", "increased", "in", "patients", "with", "C0017612#ent", "<e1>", "POAG", ")", "as", "well", "as", "in", "animal", "models", "C0017601#ent", "<e2>", "."], "h": {"id": "C0017612", "name": "C0017612#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [20, 21]}}
{"token": ["C0971579#ent", "<e1>", "has", "a", "similar", "C0720099#ent", "<e2>", "of", "action", "to", "sildenafil", ",", "but", "is", "more", "potent", "and", "selective", "biochemically", "."], "h": {"id": "C0971579", "name": "C0971579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [5, 6]}}
{"token": ["C0151718#ent", "<e1>", "also", "observed", "to", "extract", "a", "pool", "of", "C0040663#ent", "<e2>", "Talpha", ")", "from", "ROS", "membranes"], "h": {"id": "C0151718", "name": "C0151718#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040663", "name": "C0040663#ent", "pos": [9, 10]}}
{"token": ["One", "hundred", "and", "sixteen", "women", ",", "including", "66", "with", "von", "Willebrand's", "disease", "C1710605#ent", "<e1>", ")", ",", "30", "carriers", "of", "C0019069#ent", "<e2>", "and", "20", "with", "factor", "XI", "FXI", ")", "deficiency", "were", "interviewed", "and", "their", "gynaecological", "history", "."], "h": {"id": "C1710605", "name": "C1710605#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [19, 20]}}
{"token": ["The", "most", "common", "inherited", "bleeding", "disorders", "women", "are", "von", "Willebrand", "disease", "C1710605#ent", "<e1>", ")", ",", "carriership", "of", "C0019069#ent", "<e2>", "B", ",", "and", "factor", "XI", "FXI", ")", "deficiency", "."], "h": {"id": "C1710605", "name": "C1710605#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [17, 18]}}
{"token": ["C0354594#ent", "<e1>", "Flolan-Glaxo", "Wellcome", ")", ",", "also", "known", "as", "C0205911#ent", "<e2>", ",", "has", "been", "approved", "by", "the", "US", "Food", "and", "Drug", "Administration", "continuous", "intravenous", "treatment", "primary", "pulmonary", "hypertension"], "h": {"id": "C0354594", "name": "C0354594#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0205911", "name": "C0205911#ent", "pos": [9, 10]}}
{"token": ["Reactivity", "against", "this", "antigen", "was", "also", "observed", "in", "all", "sera", "from", "E.", "multilocularis", ",", "C0338437#ent", "<e1>", ",", "and", "schistosomiasis", "patients", "as", "well", "as", "in", "some", "C0016085#ent", "<e2>", "cases", "."], "h": {"id": "C0338437", "name": "C0338437#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0016085", "name": "C0016085#ent", "pos": [25, 26]}}
{"token": ["To", "investigate", "the", "potential", "roles", "of", "PMP22", ",", "we", "engineered", "a", "novel", "knock-out", "(-/-)", "mouse", "line", "replacing", "the", "first", "two", "coding", "exons", "C1419148#ent", "<e1>", "with", "the", "C0022959#ent", "<e2>", "reporter", "."], "h": {"id": "C1419148", "name": "C1419148#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0022959", "name": "C0022959#ent", "pos": [26, 27]}}
{"token": ["Collectively", ",", "these", "examples", "represent", "families", "of", "viruses", "with", "differing", "C1517495#ent", "<e1>", "differing", "numbers", "of", "C1136366#ent", "<e2>", "differing", "replication", "strategies", "."], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1136366", "name": "C1136366#ent", "pos": [15, 16]}}
{"token": ["The", "inhibition", "of", "LTB4", "synthesis", "by", "C0245109#ent", "<e1>", "suggests", "the", "possibility", "that", "this", "new", "C0072522#ent", "<e2>", "plays", "a", "modulatory", "role", "in", "immunity", "and", "inflammation", "."], "h": {"id": "C0245109", "name": "C0245109#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [14, 15]}}
{"token": ["The", "interleukin-1", "receptor", "antagonist", "IL-1ra", "or", "C0245109#ent", "<e1>", ")", "is", "a", "small", ",", "C0072522#ent", "<e2>", "competitively", "inhibits", "the", "biological", "activities", "interleukin-1", "(", "IL-1", ")", "."], "h": {"id": "C0245109", "name": "C0245109#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [13, 14]}}
{"token": ["The", "C1334889#ent", "<e1>", "Drosophila", "encodes", "a", "C0021699#ent", "<e2>", "homology", "to", "EGF", "that", ",", "in", "a", "variety", "of", "tissues", ",", "appears", "to", "mediate", "cell", "interactions", "for", "cell", "fate", "."], "h": {"id": "C1334889", "name": "C1334889#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}}
{"token": ["The", "C1334889#ent", "<e1>", "Drosophila", "encodes", "a", "large", "C0021699#ent", "<e2>", "in", "cell-cell", "interactions", "cell", "fate", "decisions", "in", "the", "Drosophila", "embryo", "."], "h": {"id": "C1334889", "name": "C1334889#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [7, 8]}}
{"token": ["RalGDS", "is", "a", "C1366909#ent", "<e1>", "ral", "p24", "a", "member", "of", "small", "C0086376#ent", "<e2>"], "h": {"id": "C1366909", "name": "C1366909#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Pre-treatment", "with", "motapizone", ",", "RP73401", ",", "rolipram", "or", "the", "C2936829#ent", "<e1>", "8-phenyltheophylline", ",", "did", "not", "significantly", "decrease", "responses", "to", "either", "C3274161#ent", "<e2>", "or", "LTC(4", ")", "."], "h": {"id": "C2936829", "name": "C2936829#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [20, 21]}}
{"token": ["The", "apparent", "specific", "activity", "of", "glyceraldehyde-3-phosphate", "dehydrogenase", "encoded", "by", "the", "C0342194#ent", "<e1>", "structural", "gene", "severalfold", "lower", "than", "the", "enzymes", "encoded", "by", "C1848805#ent", "<e2>", "or", "TDH2", "."], "h": {"id": "C0342194", "name": "C0342194#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1848805", "name": "C1848805#ent", "pos": [21, 22]}}
{"token": ["This", "loss", "of", "biological", "rhythms", "the", "TDH1-deleted", "mutant", "was", "rescued", "by", "the", "expression", "of", "C1848805#ent", "<e1>", "but", "not", "of", "TDH2", "or", "C0342194#ent", "<e2>", "under", "the", "control", "of", "the", "C1848805#ent", "<e1>", "promoter", "."], "h": {"id": "C0342194", "name": "C0342194#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1848805", "name": "C1848805#ent", "pos": [14, 15]}}
{"token": ["We", "studied", "C0035334#ent", "<e1>", "the", "offspring", "of", "Royal", "College", "of", "Surgeons", "(", "C2699120#ent", "<e2>", ")", "and", "Wistar", "albino", "rats", "."], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2699120", "name": "C2699120#ent", "pos": [12, 13]}}
{"token": ["We", "also", "show", "that", "overexpression", "of", "C1335290#ent", "<e1>", ",", "a", "potential", "yeast", "functional", "homolog", "of", "C1428890#ent", "<e2>", "also", "protects", "cells", "from", "osmotic", "stress"], "h": {"id": "C1335290", "name": "C1335290#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1428890", "name": "C1428890#ent", "pos": [15, 16]}}
{"token": ["Up", "to", "a", "third", "of", "these", "patients", "have", "two", "or", "more", "complications", ",", "such", "as", "C3714636#ent", "<e1>", "from", "two", "different", "opportunistic", "organisms", "or", "an", "C0029118#ent", "<e2>", "a", "drug-induced", "pulmonary", "complication"], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029118", "name": "C0029118#ent", "pos": [24, 25]}}
{"token": ["In", "vitro", "assays", "revealed", "that", "C0626201#ent", "<e1>", "(", "NRG1", ")", "induces", "expression", "of", "myelin", "protein", "zero", "C1417248#ent", "<e2>", ")", "."], "h": {"id": "C0626201", "name": "C0626201#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417248", "name": "C1417248#ent", "pos": [16, 17]}}
{"token": ["Calpain", "is", "a", "C1436406#ent", "<e1>", "has", "two", "ubiquitously", "distributed", "mammalian", "isoforms", ",", "namely", "calpain", "1", "C0006784#ent", "<e2>", "mu-calpain", "and", "CAPN1", ")", "and", "calpain", "2", "calpain", "II", "m-calpain", "and", "CAPN2", ")", "."], "h": {"id": "C1436406", "name": "C1436406#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "the", "mechanism", "of", "C1416903#ent", "<e1>", "in", "the", "livers", "of", "C1419876#ent", "<e2>", "rats", "showing", "apparent", "signs", "of", "hepatitis", "."], "h": {"id": "C1416903", "name": "C1416903#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419876", "name": "C1419876#ent", "pos": [11, 12]}}
{"token": ["The", "requirement", "of", "NADPH-gs", "for", "enhanced", "C1416903#ent", "<e1>", "in", "the", "livers", "of", "hepatitic", "C1419876#ent", "<e2>", "rats", "indicates", "the", "consumption", "of", "NADPH", "during", "reactions", "leading", "to", "C1416903#ent", "<e1>", "."], "h": {"id": "C1416903", "name": "C1416903#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419876", "name": "C1419876#ent", "pos": [13, 14]}}
{"token": ["The", "levels", "of", "C1416903#ent", "<e1>", "in", "liver", "S-9", "from", "hepatitic", "C1419876#ent", "<e2>", "rats", "were", "further", "increased", "by", "incubating", "liver", "S-9", "at", "37", "degrees", "C", "in", "the", "presence", "of", "NADPH-gs", "."], "h": {"id": "C1416903", "name": "C1416903#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419876", "name": "C1419876#ent", "pos": [10, 11]}}
{"token": ["Inhibition", "of", "IMPDH", "or", "TOP1", "activity", ",", "antisense", "treatment", "C1332416#ent", "<e1>", ",", "or", "overexpression", "of", "C1421451#ent", "<e2>", ",", "sensitized", "resistant", "HT29", "cells", "MTX", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421451", "name": "C1421451#ent", "pos": [15, 16]}}
{"token": ["Fluctuation", "analyses", "that", "these", "mutator", "mutants", "have", "increased", "rates", "of", "spontaneous", "mutation", "at", "3", "C0678933#ent", "<e1>", "(", "resistance", "to", "C0029904#ent", "<e2>", ",", "blasticidin", "S", "tunicamycin", ")", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [19, 20]}}
{"token": ["C0137996#ent", "<e1>", "an", "alkaline", "agent", "has", "been", "recommended", "for", "the", "prevention", "of", "C0022650#ent", "<e2>", "in", "distal", "renal", "tubular", "acidosis", "RTA", ")", "."], "h": {"id": "C0137996", "name": "C0137996#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [12, 13]}}
{"token": ["Neither", "C2987154#ent", "<e1>", "inhibitor", "nor", "PTK", "inhibitor", "affected", "amylase", "secretion", "evoked", "by", "low", "doses", "C0055509#ent", "<e2>", ",", "CCK-5", ",", "and", "CCK-4", "."], "h": {"id": "C2987154", "name": "C2987154#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0055509", "name": "C0055509#ent", "pos": [14, 15]}}
{"token": ["Transplanted", "syngeneic", "hepatocytes", "survive", "indefinitively", "in", "rodents", ",", "allowing", "correction", "of", "various", "inherited", "C0014442#ent", "<e1>", "defects", "or", "enhancing", "recipient", "survival", "experimentally", "induced", "C0162557#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [22, 23]}}
{"token": ["The", "patients", "were", "divided", "into", "two", "treatment", "groups", "one", "with", "11", "patients", "receiving", "C0074391#ent", "<e1>", "the", "other", "with", "10", "patients", "receiving", "C0792408#ent", "<e2>"], "h": {"id": "C0074391", "name": "C0074391#ent", "pos": [13, 14]}, "relation": "product_component_of", "t": {"id": "C0792408", "name": "C0792408#ent", "pos": [21, 22]}}
{"token": ["Specifically", ",", "there", "is", "evidence", "that", "the", "fatty", "acids", "fish", "oil", "such", "as", "C0556150#ent", "<e1>", "and", "eicosopentaenoic", "acids", "and", "fatty", "acids", "the", "C4283784#ent", "<e2>", "series", ",", "decrease", "preadipocyte", "proliferation", "in", "cell", "lines", "reduce", "adiposity", "in", "rodents", "."], "h": {"id": "C0556150", "name": "C0556150#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [22, 23]}}
{"token": ["Clinical", "observation", "that", "tramadol", ",", "mu", "opioid", "receptor", "C3889257#ent", "<e1>", ")", "agonist", "and", "serotonin", "(", "5-HT", ")", "C0242980#ent", "<e2>", "has", "a", "hypoglycemic", "effect", "type", "2", "diabetes", "patients", "."], "h": {"id": "C3889257", "name": "C3889257#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242980", "name": "C0242980#ent", "pos": [17, 18]}}
{"token": ["C0756787#ent", "<e1>", "did", "not", "affect", "adenylate", "or", "C0018358#ent", "<e2>", "inhibited", "cyclic", "AMP-", "and", "cyclic", "GMP-phosphodiesterase", "activities", "."], "h": {"id": "C0756787", "name": "C0756787#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018358", "name": "C0018358#ent", "pos": [7, 8]}}
{"token": ["The", "renal", "responses", "the", "C0030956#ent", "<e1>", "gamma-L-glutamyl-L-dopa", "(", "gludopa", ")", "and", "gamma-L-glutamyl-L-tyrosine", "(", "C0061069#ent", "<e2>", ")", "were", "compared", "when", "given", "intravenously", "in", "six", "normal", "male", "volunteers", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0061069", "name": "C0061069#ent", "pos": [13, 14]}}
{"token": ["The", "prevalence", "of", "the", "mutated", "C0919427#ent", "<e1>", "677TT", "genotype", "and", "the", "677", "C2827459#ent", "<e2>", "normal", "controls", "10.0", "%", "and", "31.3", "%", ",", "respectively", "."], "h": {"id": "C0919427", "name": "C0919427#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2827459", "name": "C2827459#ent", "pos": [12, 13]}}
{"token": ["By", "contrast", ",", "the", "mRNA", "levels", "of", "htrA", "and", "C1567679#ent", "<e1>", "were", "decreased", "after", "induction", "of", "the", "C0002272#ent", "<e2>", "overexpression", "."], "h": {"id": "C1567679", "name": "C1567679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [17, 18]}}
{"token": ["Cellular", "accumulation", "vincristine", "and", "cisplatin", "in", "human", "C3539701#ent", "<e1>", "cDNA", "transfectants", "decreased", ",", "but", "not", "of", "C0015133#ent", "<e2>", "."], "h": {"id": "C3539701", "name": "C3539701#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [16, 17]}}
{"token": ["Expression", "of", "human", "and", "rat", "C3539701#ent", "<e1>", "enhanced", "the", "resistance", "of", "MDCK", "cells", "C0015133#ent", "<e2>", "5.0-fold", "and", "3.8-fold", "and", "to", "vincristine", "2.3-", "and", "6.0-fold", ",", "respectively", "."], "h": {"id": "C3539701", "name": "C3539701#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [13, 14]}}
{"token": ["It", "is", "concluded", "that", "C0270639#ent", "<e1>", "represent", "an", "important", "and", "underrecognized", "cause", "of", "neonatal", "C0751495#ent", "<e2>", "."], "h": {"id": "C0270639", "name": "C0270639#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [14, 15]}}
{"token": ["This", "case", "also", "extends", "the", "clinical", "spectrum", "C0270639#ent", "<e1>", "include", "recurrent", "transient", "ischemic", "attacks", "with", "C0751495#ent", "<e2>", "."], "h": {"id": "C0270639", "name": "C0270639#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [15, 16]}}
{"token": ["Maintaining", "adequate", "blood", "supply", "the", "C1412362#ent", "<e1>", "and", "teaching", "the", "patient", "how", "to", "prevent", "new", "C0149745#ent", "<e2>", "are", "the", "foci", "of", "post-operative", "care"], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149745", "name": "C0149745#ent", "pos": [15, 16]}}
{"token": ["Increased", "C1839729#ent", "<e1>", "is", "associated", "with", "resistance", "to", "the", "NM", "effects", "of", "C0010464#ent", "<e2>", "(ND)MR", "."], "h": {"id": "C1839729", "name": "C1839729#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010464", "name": "C0010464#ent", "pos": [12, 13]}}
{"token": ["The", "two", "active", "lactam", "analogues", "retain", "the", "selectivity", "exhibited", "by", "the", "naturally", "occurring", "peptide", "for", "the", "alpha/delta", "subunit", "of", "C1839729#ent", "<e1>", ",", "as", "judged", "by", "competition", "experiments", "the", "C0010464#ent", "<e2>", "antagonist", "metocurine", "."], "h": {"id": "C1839729", "name": "C1839729#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010464", "name": "C0010464#ent", "pos": [28, 29]}}
{"token": ["In", "case", "of", "persistent", "C0004659#ent", "<e1>", ",", "accompanying", ",", "for", "example", ",", "C0022650#ent", "<e2>", ",", "the", "vaccine", "had", "no", "effect"], "h": {"id": "C0004659", "name": "C0004659#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [12, 13]}}
{"token": ["The", "molar", "ratio", "two", "compounds", "(", "C0006644#ent", "<e1>", ")", "was", "used", "to", "phenotype", "C1620185#ent", "<e2>", ",", "while", "the", "molar", "ratio", "two", "other", "compounds", "(", "5-acetylamino-6-formylamino-3-methyluracil/1-methylxanthine", ")", "served", "to", "phenotype", "NAT2", "."], "h": {"id": "C0006644", "name": "C0006644#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [13, 14]}}
{"token": ["The", "rate", "of", "C0006644#ent", "<e1>", "generation", "also", "correlated", "with", "C1620185#ent", "<e2>", "levels", "."], "h": {"id": "C0006644", "name": "C0006644#ent", "pos": [3, 4]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [9, 10]}}
{"token": ["These", "results", "strongly", "suggest", "that", "PHA1", "and", "C0221043#ent", "<e1>", "allelic", "variants", "caused", "by", "mutations", "in", "genes", "encoding", "C0599220#ent", "<e2>", "of", "this", "sodium", "channel"], "h": {"id": "C0221043", "name": "C0221043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [17, 18]}}
{"token": ["C1313359#ent", "<e1>", "encodes", "an", "C1335081#ent", "<e2>", "catalyzes", "the", "removal", "of", "8-oxodeoxyguanosine", "from", "DNA", "."], "h": {"id": "C1313359", "name": "C1313359#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335081", "name": "C1335081#ent", "pos": [4, 5]}}
{"token": ["Although", "most", "of", "the", "95", "SPF", "farms", "had", "a", "low", "risk", "introduction", "of", "C0005943#ent", "<e1>", "one", "disease", "was", "introduced", "into", "12", "farms", "and", "two", "C0012634#ent", "<e2>", "were", "introduced", "into", "one", "farm", "."], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["We", "present", "three", "cases", "of", "biopsy-proven", "C0242770#ent", "<e1>", "in", "patients", "with", "scleroderma", "spectrum", "disease", "including", "diffuse", "cutaneous", "SSc", ",", "C0026272#ent", "<e2>", "SSc", "features", ",", "and", "limited", "cutaneous", "SSc", "that", "later", "evolved", "to", "dermatomyositis/SSc", "overlap", "."], "h": {"id": "C0242770", "name": "C0242770#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026272", "name": "C0026272#ent", "pos": [19, 20]}}
{"token": ["The", "retardation", "of", "C0028941#ent", "<e1>", ",", "a", "slowly", "migrating", "hydrolase", ",", "versus", "C1447020#ent", "<e2>", "a", "rapidly", "transported", "enzyme", ",", "is", "neither", "due", "to", "differential", "trimming", "of", "N-linked", "carbohydrates", "due", "to", "oligomerization", "."], "h": {"id": "C0028941", "name": "C0028941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1447020", "name": "C1447020#ent", "pos": [12, 13]}}
{"token": ["In", "secretor", "blood", "group", "humans", ",", "both", "the", "C0028941#ent", "<e1>", "and", "the", "C1447020#ent", "<e2>", "type", "3", "blood", "group", "determinants", "."], "h": {"id": "C0028941", "name": "C0028941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1447020", "name": "C1447020#ent", "pos": [12, 13]}}
{"token": ["Cohesin", "is", "a", "C1422073#ent", "<e1>", "is", "highly", "conserved", "in", "eukaryotes", "and", "has", "close", "C4277608#ent", "<e2>", "in", "bacteria", "."], "h": {"id": "C1422073", "name": "C1422073#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "endothelin", "antagonists", "inhibit", "EDCF-mediated", "contractions", "by", "blocking", "endothelinA", "receptors", "that", ",", "in", "addition", ",", "C0252643#ent", "<e1>", "antagonizes", "the", "direct", "stimulation", "of", "C1420619#ent", "<e2>"], "h": {"id": "C0252643", "name": "C0252643#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420619", "name": "C1420619#ent", "pos": [25, 26]}}
{"token": ["C2697656#ent", "<e1>", "increased", "the", "transcription", "of", "C1336646#ent", "<e2>", "mRNA", "in", "monocytes", "and", "macrophages", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336646", "name": "C1336646#ent", "pos": [6, 7]}}
{"token": ["C2697656#ent", "<e1>", "also", "stimulated", "the", "release", "of", "soluble", "C1336646#ent", "<e2>", "from", "the", "monocytes", "and", "macrophages", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336646", "name": "C1336646#ent", "pos": [8, 9]}}
{"token": ["Using", "the", "C1419693#ent", "<e1>", "and", "AM2", "disks", "(", "in", "contrast", "to", "the", "C1425194#ent", "<e2>", "and", "AM10", "disks", ")", ",", "we", "correctly", "differentiated", "all", "the", "Penr", "from", "Pens", "isolates", "."], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1425194", "name": "C1425194#ent", "pos": [12, 13]}}
{"token": ["This", "study", "demonstrated", "the", "existence", "of", "the", "C3887685#ent", "<e1>", "polymorphism", "in", "Canadian", "Inuit", "while", "the", "frequencies", "of", "C0002085#ent", "<e2>", "variants", "of", "C3887685#ent", "<e1>", "point", "to", "the", "uniqueness", "of", "this", "population", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [17, 18]}}
{"token": ["The", "incidence", "of", "WHO", "degrees", "II", "degrees", "III", "C0085083#ent", "<e1>", "was", "significantly", "lower", "in", "the", "C0209366#ent", "<e2>", "than", "in", "the", "Buserelin", "group", "(", "1.1", "%", "vs.", "6.5", "%", ",", "p=0.03", ")", "."], "h": {"id": "C0085083", "name": "C0085083#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0209366", "name": "C0209366#ent", "pos": [15, 16]}}
{"token": ["Using", "the", "yeast", "two-hybrid", "system", "we", "have", "now", "isolated", "a", "new", "C1335818#ent", "<e1>", "JAB", ",", "which", "is", "a", "C3275256#ent", "<e2>", "interacts", "with", "the", "Jak2", "tyrosine-kinase", "JH1", "domain", "."], "h": {"id": "C1335818", "name": "C1335818#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3275256", "name": "C3275256#ent", "pos": [18, 19]}}
{"token": ["C0251991#ent", "<e1>", ",", "another", "PI-3K", "inhibitor", "also", "enhances", "Caspase-3-like", "activity", "but", "inhibitors", "for", "C1334539#ent", "<e2>", "calmodulin", "dependent", "kinase", "not", "have", "any", "effect", "on", "the", "Caspase-3-like", "activity"], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [13, 14]}}
{"token": ["At", "matched", "levels", "of", "end-systolic", "stress", ",", "C0012963#ent", "<e1>", "increased", "and", "C0042523#ent", "<e2>", "decreased", "the", "LV", "shortening", "fraction"], "h": {"id": "C0012963", "name": "C0012963#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [11, 12]}}
{"token": ["This", "study", "investigated", "whether", "C1414260#ent", "<e1>", "(ET)-1-induced", "increase", "in", "myocardial", "distensibility", "is", "preserved", "in", "heart", "failure", "C1313497#ent", "<e2>", ")", "and", "whether", "it", "is", "modulated", "by", "nitric", "oxide", "NO", ")", "and", "prostaglandins", "."], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1313497", "name": "C1313497#ent", "pos": [16, 17]}}
{"token": ["Wrch1", "gene", "a", "down-stream", "target", "gene", "of", "C0812233#ent", "<e1>", "in", "C57MG", "cells", ",", "and", "encodes", "a", "C1425081#ent", "<e2>", "the", "potential", "to", "activate", "the", "JNK", "pathway"], "h": {"id": "C0812233", "name": "C0812233#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1425081", "name": "C1425081#ent", "pos": [16, 17]}}
{"token": ["C0055705#ent", "<e1>", "also", "inhibited", "C3273437#ent", "<e2>", "induction", "of", "c-fos", "mRNA", "expression", ",", "an", "additional", "marker", "of", "hypertrophy", "in", "ARCM", "(", "n", "=", "5", ",", "P", "<", "0.005", ")", "."], "h": {"id": "C0055705", "name": "C0055705#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [4, 5]}}
{"token": ["Exercise-induced", "laryngomalacia", "EIL", ")", "is", "characterized", "by", "severe", "C0013404#ent", "<e1>", ",", "stridor", ",", "and", "mild", "wheezing", "to", "prophylactic", "treatment", "beta-agonists", "and", "C0012694#ent", "<e2>"], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [21, 22]}}
{"token": ["Since", "C4082991#ent", "<e1>", "is", "an", "isomerase", "and", "mPGES-2h", "is", "a", "C1334456#ent", "<e2>", ",", "C4082991#ent", "<e1>", "can", "not", "simply", "be", "classified", "into", "one", "of", "six", "classes", "set", "by", "the", "International", "Union", "of", "Biochemistry", "Molecular", "Biology"], "h": {"id": "C4082991", "name": "C4082991#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334456", "name": "C1334456#ent", "pos": [10, 11]}}
{"token": ["Since", "mPGES-2", "is", "an", "isomerase", "and", "C4082991#ent", "<e1>", "is", "a", "C1334456#ent", "<e2>", ",", "mPGES-2", "can", "not", "simply", "be", "classified", "into", "one", "of", "six", "classes", "set", "by", "the", "International", "Union", "of", "Biochemistry", "Molecular", "Biology"], "h": {"id": "C4082991", "name": "C4082991#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334456", "name": "C1334456#ent", "pos": [10, 11]}}
{"token": ["We", "recently", "reported", "that", "C0036442#ent", "<e1>", "pretreated", "mice", "fasted", "for", "48", "h", "developed", "C0014549#ent", "<e2>", "after", "they", "were", "allowed", "to", "eat", "ad", "libidum", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [13, 14]}}
{"token": ["C0039542#ent", "<e1>", "also", "improves", "the", "liver", "(", "assessed", "by", "aspartate", "aminotransferase", "C3887708#ent", "<e2>", "total", "bilirubin", "and", "albumin/globulin", ")", "and", "kidney", "(", "assessed", "by", "creatinine", "and", "uric", "acid", "dysfunction", "induced", "by", "endotoxin", "."], "h": {"id": "C0039542", "name": "C0039542#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887708", "name": "C3887708#ent", "pos": [11, 12]}}
{"token": ["C0546849#ent", "<e1>", "]", "had", "potency", "equivalent", "to", "d-cis-diltiazem", "with", "C1839576#ent", "<e2>", "values", "of", "7.27", "and", "7.38", ",", "respectively", ",", "against", "calcium-induced", "contractions", "the", "guinea", "pig", "ileum", "."], "h": {"id": "C0546849", "name": "C0546849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [9, 10]}}
{"token": ["Purified", "preparations", "the", "restriction", "C3540790#ent", "<e1>", "free", "from", "interfering", "C0597094#ent", "<e2>", "and", "phosphatases", "were", "obtained", "by", "column", "chromatography", "phosphocellulose", "and", "heparin-sepharose", "(", "Asil", ")", "and", "phosphocellulose", "and", "DEAE-cellulose", "(", "Bsp40091", ")", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597094", "name": "C0597094#ent", "pos": [9, 10]}}
{"token": ["It", "is", "catabolized", "by", "the", "action", "of", "an", "extracellular", "plasma", "membrane-tethered", "C0020197#ent", "<e1>", "that", "is", "coordinated", "with", "intracellular", "lysosomal", "hyaluronidases", "C0017976#ent", "<e2>", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [11, 12]}, "relation": "has_structural_class", "t": {"id": "C0017976", "name": "C0017976#ent", "pos": [20, 21]}}
{"token": ["Since", "these", "enzymes", "do", "not", "have", "detectable", "C0020197#ent", "<e1>", "activity", ",", "many", "family", "84", "C0017976#ent", "<e2>", "most", "likely", "incorrectly", "annotated", "as", "hyaluronidases", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [7, 8]}, "relation": "has_structural_class", "t": {"id": "C0017976", "name": "C0017976#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "the", "cloning", ",", "expression", ",", "biochemical", "characterization", "and", "crystal", "structure", "determination", "of", "the", "C0020197#ent", "<e1>", "family", "56", "of", "the", "C0017976#ent", "<e2>", "reported", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [15, 16]}, "relation": "has_structural_class", "t": {"id": "C0017976", "name": "C0017976#ent", "pos": [21, 22]}}
{"token": ["The", "authors", "report", "two", "cases", "of", "C0019159#ent", "<e1>", "and", "a", "case", "of", "pancreatitis", "associated", "with", "C0063448#ent", "<e2>", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0063448", "name": "C0063448#ent", "pos": [15, 16]}}
{"token": ["It", "is", "possible", "that", "the", "C0245514#ent", "<e1>", "may", "be", "able", "to", "prevent", "or", "delay", "the", "C0007222#ent", "<e2>", "accompanies", "type", "2", "diabetes", "long-term", "studies", "are", "required", "to", "determine", "if", "this", "is", "the", "case", "."], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [15, 16]}}
{"token": ["The", "selected", "pyrazole", ",", "oxazole", "and", "C3539193#ent", "<e1>", "moderate", "inhibition", "against", "DNA", "gyrase", "C0082329#ent", "<e2>", "similar", "IC(50", ")", "values", "(", "IC(50)=9.4", "-", "25", "microg/mL", ")", "."], "h": {"id": "C3539193", "name": "C3539193#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0082329", "name": "C0082329#ent", "pos": [13, 14]}}
{"token": ["These", "mutations", "are", "located", "within", "the", "regions", "of", "the", "C0017337#ent", "<e1>", "encoding", "the", "3'-5'", "exonuclease", "A314", "T", ")", "and", "C1335439#ent", "<e2>", "(", "A684V", ")", "catalytic", "domains"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [19, 20]}}
{"token": ["Inverse", "PCR", "that", "the", "gene", "(", "adhI", ")", "was", "localised", "with", "3-hexulose-6-phosphate", "synthase", "C0242994#ent", "<e1>", ")", "and", "6-phospho-3", "hexuloisomerase", "(", "C1333690#ent", "<e2>", ")", "on", "its", "genome", "."], "h": {"id": "C0242994", "name": "C0242994#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [20, 21]}}
{"token": ["C0235394#ent", "<e1>", "remains", "prevalent", ";", "increasingly", ",", "C0221032#ent", "<e2>", "is", "reported", "."], "h": {"id": "C0235394", "name": "C0235394#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221032", "name": "C0221032#ent", "pos": [7, 8]}}
{"token": ["The", "remaining", "eleven", "ry", "alleles", "code", "for", "C1421531#ent", "<e1>", "molecules", "that", "retain", "some", "antigenic", "similarities", "to", "the", "C1883559#ent", "<e2>", "assessed", "by", "immunoelectrophoresis", "and", "six", "of", "these", "eleven", "were", "capable", "of", "intragenic", "complementation"], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [17, 18]}}
{"token": ["Evidence", "for", "the", "identity", "of", "in", "vitro", "reconstituted", "C1421531#ent", "<e1>", "ma-l", "mutants", "with", "C1883559#ent", "<e2>", "presented", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [13, 14]}}
{"token": ["Enzyme", "activities", "to", "D-", "and", "C1881354#ent", "<e1>", ",", "such", "as", "pyruvate", "kinase", "phosphofructokinase", ",", "aldolase", ",", "and", "C0022956#ent", "<e2>", "were", "measured", "in", "the", "livers", "of", "these", "rats", "."], "h": {"id": "C1881354", "name": "C1881354#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022956", "name": "C0022956#ent", "pos": [17, 18]}}
{"token": ["Seven", "patients", "(", "9.9", "%", ")", "had", "clinical", "features", "of", "C0151721#ent", "<e1>", "such", "as", "C1449721#ent", "<e2>", ",", "decreased", "sexual", "hair", "infertility", "."], "h": {"id": "C0151721", "name": "C0151721#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1449721", "name": "C1449721#ent", "pos": [14, 15]}}
{"token": ["Anabolic", "steroid", "abuse", "in", "athletes", "has", "been", "associated", "with", "wide", "range", "of", "adverse", "conditions", "including", "C0151721#ent", "<e1>", ",", "testicular", "atrophy", "impaired", "spermatogenesis", ",", "C1449721#ent", "<e2>", ",", "and", "psychiatric", "disturbance"], "h": {"id": "C0151721", "name": "C0151721#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1449721", "name": "C1449721#ent", "pos": [23, 24]}}
{"token": ["C0053355#ent", "<e1>", "concentration-dependently", "reduced", "CBF", "by", "inhibiting", "arachidonic", "acid", "metabolism", "cGMP", ",", "C1826724#ent", "<e2>", "and", "endogenous", "ATP", "consumption", "."], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "increased", "locomotor", "activity", "by", "treatment", "with", "a", "low", "dose", "endothelin-1", "(", "1", "pmol/rat", ",", "ICV", ")", "was", "antagonized", "by", "coadministration", "of", "C0253336#ent", "<e1>", ",", "but", "not", "of", "C0379142#ent", "<e2>", "."], "h": {"id": "C0253336", "name": "C0253336#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0379142", "name": "C0379142#ent", "pos": [30, 31]}}
{"token": ["In", "contrast", ",", "C0253336#ent", "<e1>", "(", "10", "microM", ")", "and", "C0379142#ent", "<e2>", "(", "10", "microM", ")", ",", "either", "alone", "or", "in", "combination", ",", "were", "without", "significant", "effect", "on", "ET-1", "concentration-response", "curves"], "h": {"id": "C0253336", "name": "C0253336#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0379142", "name": "C0379142#ent", "pos": [10, 11]}}
{"token": ["One", "order", ",", "the", "Rickettsiales", ",", "containing", "3", "families", ",", "the", "C0035592#ent", "<e1>", ",", "Phagosomaphilaceae", ",", "and", "the", "C0004773#ent", "<e2>", "(", "?", ")"], "h": {"id": "C0035592", "name": "C0035592#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004773", "name": "C0004773#ent", "pos": [18, 19]}}
{"token": ["Three", "treatment", "modalities", "now", "available", "for", "the", "treatment", "of", "C0040156#ent", "<e1>", "childhood", ":", "antithyroid", "drugs", "ATD", ")", ",", "surgery", "and", "radioactive", "iodine", "C2986859#ent", "<e2>", ")", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986859", "name": "C2986859#ent", "pos": [22, 23]}}
{"token": ["C0012963#ent", "<e1>", "infusion", "was", "well-tolerated", ",", "despite", "causing", "C0235710#ent", "<e2>", "24", "patients", "(", "96", "%", ")", "."], "h": {"id": "C0012963", "name": "C0012963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235710", "name": "C0235710#ent", "pos": [8, 9]}}
{"token": ["Both", "C2987364#ent", "<e1>", "FKBP12", "and", "an", "F43Y", "FKBP12", "mutant", "with", "reduced", "C0136073#ent", "<e2>", "supported", "mdr3", "function", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0136073", "name": "C0136073#ent", "pos": [11, 12]}}
{"token": ["Together", ",", "the", "data", "implicate", "the", "C1424610#ent", "<e1>", "a", "major", "C3537377#ent", "<e2>", "the", "infectious", "entry", "influenza", "virus", "and", "perhaps", "other", "enveloped", "viruses", "into", "murine", "macrophages", "."], "h": {"id": "C1424610", "name": "C1424610#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537377", "name": "C3537377#ent", "pos": [10, 11]}}
{"token": ["In", "assays", "for", "C0060180#ent", "<e1>", "glucuronide(s", ")", "and", "C0060180#ent", "<e1>", "conjugates", ",", "urine", "was", "treated", "with", "beta-glucuronidase", "and", "C0061454#ent", "<e1>", ",", "respectively", ",", "and", "the", "liberated", "C0060180#ent", "<e1>", "was", "quantified", "by", "HPLC-ED", "."], "h": {"id": "C0061454", "name": "C0061454#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0060180", "name": "C0060180#ent", "pos": [3, 4]}}
{"token": ["C1332789#ent", "<e1>", "differentiation", "triggers", "increased", "expression", "of", "C1418415#ent", "<e2>", "and", "PDE2A", ",", "while", "GM-CSF", "causes", "a", "large", "increase", "only", "in", "C1418415#ent", "<e2>", "."], "h": {"id": "C1332789", "name": "C1332789#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418415", "name": "C1418415#ent", "pos": [7, 8]}}
{"token": ["C4053961#ent", "<e1>", "can", "occur", "in", "patients", "presenting", "bone", "and", "C0263661#ent", "<e2>", "various", "origins", "."], "h": {"id": "C4053961", "name": "C4053961#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [9, 10]}}
{"token": ["C0014118#ent", "<e1>", "diagnosed", "in", "a", "21-year-old", "itinerant", "farm", "worker", "hospitalized", "for", "C0034063#ent", "<e2>"], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [11, 12]}}
{"token": ["It", "is", "clear", "that", "this", "hormone", "is", "intimately", "involved", "in", "the", "regulation", "of", "fluid", "and", "C3536863#ent", "<e1>", "balance", ",", "vascular", "tone", "and", "the", "pathophysiology", "of", "C0019099#ent", "<e2>", "but", "many", "questions", "remain", "unanswered", "."], "h": {"id": "C3536863", "name": "C3536863#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [25, 26]}}
{"token": ["FP", "and", "C1422585#ent", "<e1>", "did", "not", "increase", "C0072052#ent", "<e2>", "deoxypyridinoline", "crosslinks", "both", "markers", "of", "bone", "resorption"], "h": {"id": "C1422585", "name": "C1422585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072052", "name": "C0072052#ent", "pos": [7, 8]}}
{"token": ["One", "principal", "C0304402#ent", "<e1>", "to", "endothelial", "cell", "growth", "migration", ",", "C1522575#ent", "<e2>", "VEGF", ")", ",", "is", "synthesized", "and", "secreted", "by", "thyroid", "cancer", "cells"], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [10, 11]}}
{"token": ["There", "is", "increasing", "understanding", "about", "the", "pathogenesis", "of", "placental", "dysfunction", "inherited", "thrombophilia", "and", "C0085278#ent", "<e1>", "pregnancy", "outcomes", "in", "these", "conditions", "parallel", "those", "reported", "for", "C1414137#ent", "<e2>", "."], "h": {"id": "C0085278", "name": "C0085278#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414137", "name": "C1414137#ent", "pos": [24, 25]}}
{"token": ["Most", "cases", "in", "adults", "are", "caused", "by", "acquired", "autoantibodies", "inhibit", "ADAMTS13", ",", "a", "C0025543#ent", "<e1>", "that", "cleaves", "von", "Willebrand", "factor", "nascent", "platelet-rich", "thrombi", "prevent", "hemolysis", ",", "C0040034#ent", "<e2>", ",", "and", "tissue", "infarction"], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [26, 27]}}
{"token": ["C0238339#ent", "<e1>", "also", "closely", "related", "to", "various", "C0023895#ent", "<e2>"], "h": {"id": "C0238339", "name": "C0238339#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [7, 8]}}
{"token": ["Cardiovascular", "surgeons", "treat", "diabetic", "patients", "either", "because", "diabetes", "is", "incidental", "to", "another", "disease", "requiring", "surgery", ",", "or", "due", "to", "C0011884#ent", "<e1>", "complication", "such", "as", "C1096458#ent", "<e2>", "neuropathy", "or", "infection", "."], "h": {"id": "C0011884", "name": "C0011884#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1096458", "name": "C1096458#ent", "pos": [24, 25]}}
{"token": ["Uncontrolled", "activation", "of", "C1413109#ent", "<e1>", "has", "been", "linked", "to", "tissue", "damage", "neuronal", "and", "C0010054#ent", "<e2>", "traumatic", "spine", "brain", "injuries", "and", "multiple", "sclerosis", "Alzheimer's", "disease"], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [13, 14]}}
{"token": ["The", "C1413109#ent", "<e1>", "inhibitory", "activity", "of", "C0010054#ent", "<e2>", "significantly", "lower", "than", "normal", "cardiac", "tissue", "samples", "."], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [6, 7]}}
{"token": ["C1419027#ent", "<e1>", "interfaces", "with", "the", "C0208355#ent", "<e2>", ",", "whereas", "Rpn1", "sits", "atop", "C1419027#ent", "<e1>", ",", "serving", "as", "a", "docking", "site", "a", "substrate-recruitment", "factor", "."], "h": {"id": "C0208355", "name": "C0208355#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419027", "name": "C1419027#ent", "pos": [0, 1]}}
{"token": ["The", "formation", "of", "these", "complexes", "may", "be", "significant", "in", "the", "C0596107#ent", "<e1>", "Autm", "since", "C0056650#ent", "<e2>", "is", "produced", "by", "potential", "target", "cells", "such", "as", "polymorphonuclear", "leukocytes"], "h": {"id": "C0596107", "name": "C0596107#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0056650", "name": "C0056650#ent", "pos": [14, 15]}}
{"token": ["The", "results", "indicate", "that", ",", "in", "C0403399#ent", "<e1>", "kidneys", ",", "the", "damaged", "podocytes", "induce", "progressive", "C0268747#ent", "<e2>", "expansion", "and", "capillary", "obliteration"], "h": {"id": "C0403399", "name": "C0403399#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0268747", "name": "C0268747#ent", "pos": [15, 16]}}
{"token": ["C0403399#ent", "<e1>", "the", "Finnish", "type", "CNF", ")", "and", "C0268747#ent", "<e2>", "DMS", ")", "are", "rare", "causes", "of", "renal", "failure", "infants", "."], "h": {"id": "C0403399", "name": "C0403399#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0268747", "name": "C0268747#ent", "pos": [8, 9]}}
{"token": ["Immunohistochemically", "the", "expressions", "of", "Factor", "VIII", "C1825843#ent", "<e1>", "negativity", "of", "C2936882#ent", "<e2>", "and", "progesterone", "receptors", "found", "."], "h": {"id": "C1825843", "name": "C1825843#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [10, 11]}}
{"token": ["It", "is", "concluded", "that", "the", "antagonism", "between", "C0021246#ent", "<e1>", "or", "phenylbutazone", "and", "non-steroidal", "anti-inflammatory", "drugs", "than", "C0005011#ent", "<e2>", "is", "present", "at", "some", "receptors", "but", "not", "all", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005011", "name": "C0005011#ent", "pos": [16, 17]}}
{"token": ["C0021246#ent", "<e1>", ",", "acetyl", "salicylic", "acid", "eterylate", "and", "C0005011#ent", "<e2>", "increased", "the", "protein", "kinase", "activity", "liver", ",", "lung", "and", "heart", "after", "in", "vivo", "administration", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005011", "name": "C0005011#ent", "pos": [8, 9]}}
{"token": ["Using", "C1706240#ent", "<e1>", "expression", "and", "BrdU-labeling", "kinetics", ",", "both", "C0268314#ent", "<e2>", "and", "langerin(+", ")", "DDCs", "were", "found", "to", "coexist", "in", "wild-type", "mice", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268314", "name": "C0268314#ent", "pos": [9, 10]}}
{"token": ["Lithocholic", "acid", "C1706240#ent", "<e1>", ")", "and", "its", "sulfate", "(", "C0268314#ent", "<e2>", ")", "and", "glucuronide", "(", "LCG", ")", "derivatives", "are", "potent", "cholestatic", "agents", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268314", "name": "C0268314#ent", "pos": [9, 10]}}
{"token": ["Genotype/phenotype", "analysis", "that", "all", "(", "21", "of", "21", ")", "patients", "with", "C0694895#ent", "<e1>", "deletions", "extending", "3", "'", "into", "the", "PKD1", "gene", "C0268800#ent", "<e2>"], "h": {"id": "C0694895", "name": "C0694895#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268800", "name": "C0268800#ent", "pos": [21, 22]}}
{"token": ["The", "number", "of", "donor", "cells", "each", "sample", "was", "estimated", "using", "quantitative", "polymerase", "chain", "reaction", "targeting", "a", "gender-specific", "gene", "on", "the", "Y-chromosome", ",", "the", "C0949635#ent", "<e1>", "and", "a", "control", "deoxyribonucleic", "acid", "in", "male", "and", "female", "cell", "deoxyribonucleic", "acid", "the", "C0127082#ent", "<e2>"], "h": {"id": "C0949635", "name": "C0949635#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [38, 39]}}
{"token": ["Undetected", "anatomical", "variations", "of", "the", "short", "saphenous", "vein", "C1705597#ent", "<e1>", ")", "are", "a", "major", "contributing", "factor", "to", "recurrent", "C0042345#ent", "<e2>", "the", "SSV", "area"], "h": {"id": "C1705597", "name": "C1705597#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [18, 19]}}
{"token": ["4-Hydroxy-2-nonenal", ",", "4-oxo-2-nonenal", ",", "and", "cyclopentenone", "prostaglandin", "A", "J", ",", "which", "all", "contain", "alpha", ",", "beta-unsaturated", "carbonyls", ",", "inhibited", "the", "C0031727#ent", "<e1>", "of", "cellular", "C1431123#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [20, 21]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1431123", "name": "C1431123#ent", "pos": [24, 25]}}
{"token": ["Between", "them", ",", "these", "C0031727#ent", "<e1>", "may", "mediate", "the", "physiological", "effects", "C1431123#ent", "<e2>", ",", "including", "its", "tumour", "suppressor", "function"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1431123", "name": "C1431123#ent", "pos": [11, 12]}}
{"token": ["C0003015#ent", "<e1>", "inducible", "nitric", "oxide", "synthase", "be", "useful", "probes", "of", "vascular", "dysfunction", "C0243026#ent", "<e2>", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [12, 13]}}
{"token": ["C0003015#ent", "<e1>", "been", "successfully", "used", "in", "ischemia-reperfusion", "injury", "inflammation", "and", "C0243026#ent", "<e2>", "in", "several", "experimental", "models"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [10, 11]}}
{"token": ["A", "combination", "of", "NA", "depletion", "and", "intracerebroventricular", "injection", "of", "C0026818#ent", "<e1>", "significantly", "raised", "the", "onset", "pressures", "C0234376#ent", "<e2>", "and", "convulsions", ",", "i.e.", "delayed", "the", "appearance", "of", "the", "HPNS", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0234376", "name": "C0234376#ent", "pos": [16, 17]}}
{"token": ["It", "is", "suggested", "that", "aminopeptidase", "inhibitors", "such", "as", "C2346741#ent", "<e1>", "and", "bestatin", ",", "deplete", "sensitive", "tumor", "cells", "C3539947#ent", "<e2>", "blocking", "protein", "recycling", "and", "this", "generates", "an", "antiproliferative", "effect", "."], "h": {"id": "C2346741", "name": "C2346741#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [17, 18]}}
{"token": ["Similar", ",", "though", "smaller", "changes", "in", "C1428159#ent", "<e1>", ",", "were", "seen", "in", "untreated", "patients", "whose", "C0000970#ent", "<e2>", "level", "fell", "below", "the", "treatment", "line"], "h": {"id": "C1428159", "name": "C1428159#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [15, 16]}}
{"token": ["The", "C1428159#ent", "<e1>", "activity", "was", "dose-", "and", "time-related", "to", "C0000970#ent", "<e2>", "."], "h": {"id": "C1428159", "name": "C1428159#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [9, 10]}}
{"token": ["However", ",", "solely", "MICA", "and", "C1423034#ent", "<e1>", "reach", "the", "cellular", "surface", "engage", "NKG2D", ",", "whereas", "MICB", ",", "C3539758#ent", "<e2>", "and", "ULBP2", "are", "selectively", "retained", "in", "the", "endoplasmic", "reticulum", "UL16", "."], "h": {"id": "C1423034", "name": "C1423034#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539758", "name": "C3539758#ent", "pos": [17, 18]}}
{"token": ["The", "same", "mutation", "was", "introduced", "into", "C1704997#ent", "<e1>", ",", "producing", "the", "sso1", "-", "1", "C0002085#ent", "<e2>", ",", "which", "also", "has", "a", "temperature-sensitive", "phenotype", ",", "although", "less", "pronounced", "than", "sso2", "-", "1", "."], "h": {"id": "C1704997", "name": "C1704997#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [14, 15]}}
{"token": ["Laboratory", "findings", "suggested", "that", "leucopenia", "and", "C1839163#ent", "<e1>", "could", "be", "due", "to", "bone", "marrow", "suppression", "C3890018#ent", "<e2>", "symptoms", "to", "an", "allergic", "reaction", "carbamazepine", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "both", "low", "and", "high", "doses", "C0286651#ent", "<e1>", "lead", "to", "early", "progressive", "improvement", "in", "endothelial", "function", "patients", "with", "C0020443#ent", "<e2>"], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [20, 21]}}
{"token": ["Dose-dependent", "reductions", "in", "total", "cholesterol", "low", "density", "lipoprotein", "(LDL)-cholesterol", "triglyceride", "levels", "have", "been", "observed", "with", "C0286651#ent", "<e1>", "in", "patients", "with", "C0020443#ent", "<e2>", "and", "in", "patients", "with", "hypertriglyceridaemia", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [20, 21]}}
{"token": ["innervated", "C0751950#ent", "<e1>", "their", "sensitivity", "to", "the", "cholinergic", "blocking", "agents", "D-tubocurarine", "and", "C0062637#ent", "<e2>", "."], "h": {"id": "C0751950", "name": "C0751950#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0062637", "name": "C0062637#ent", "pos": [12, 13]}}
{"token": ["It", "has", "been", "validated", "for", "use", "in", "various", "forms", "of", "C0003864#ent", "<e1>", ",", "but", "not", "in", "C0003872#ent", "<e2>", "PsA", ")", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [16, 17]}}
{"token": ["The", "C0003864#ent", "<e1>", "in", "the", "category", "of", "spondyloarthropathy", "(", "ankylosing", "spondylitis", "C0003872#ent", "<e2>", "reactive", "arthritis", "undifferentiated", "spondyloarthropathy", "and", "arthritis", "associated", "with", "inflammatory", "bowel", "disease", "may", "cause", "significant", ",", "progressive", "morbidity", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [11, 12]}}
{"token": ["C0038454#ent", "<e1>", "in", "about", "11", "%", "of", "children", "with", "C0002895#ent", "<e2>", "and", "many", "more", "develop", "silent", "infarcts"], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [9, 10]}}
{"token": ["Propranolol", "and", "C0543459#ent", "<e1>", "have", "been", "effective", "in", "preventing", "C0042510#ent", "<e2>", "for", "over", "3", "years", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [9, 10]}}
{"token": ["Four", "patients", "(", "including", "3", "patients", "who", "experienced", "recurrence", ")", "received", "amiodarone", "alone", "or", "in", "combination", "with", "C0543459#ent", "<e1>", ",", "and", "these", "drugs", "could", "effectively", "prevent", "recurrence", "of", "C0042510#ent", "<e2>", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [28, 29]}}
{"token": ["Each", "developed", "acute", "attacks", "C1739148#ent", "<e1>", "during", "pregnancy", "(", "confirmed", "C0033802#ent", "<e2>", ",", "two", ";", "presumptive", "pseudogout", ",", "two", ")", "."], "h": {"id": "C1739148", "name": "C1739148#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033802", "name": "C0033802#ent", "pos": [10, 11]}}
{"token": ["Laser", "scanning", "confocal", "fluorescence", "microscopy", "techniques", "were", "used", "to", "study", "the", "localization", "of", "von", "Willebrand", "factor", "C1336938#ent", "<e1>", ";", "Factor", "VIII-related", "antigen", "and", "thrombomodulin", "(", "transmembrane", "receptor", "C1414504#ent", "<e2>", ")", "in", "the", "microvascular", "endothelial", "cells", "the", "normal", "human", "lung", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [27, 28]}}
{"token": ["In", "fact", "it", "appeared", "that", "C1336938#ent", "<e1>", "is", "indispensable", "for", "the", "generation", "of", "C1414504#ent", "<e2>", "in", "PRP", ",", "with", "or", "without", "added", "clot", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [13, 14]}}
{"token": ["Sequencing", "the", "C1825709#ent", "<e1>", "variant", "proved", "it", "was", "a", "newly", "discovered", "C1706112#ent", "<e2>", ",", "one", "that", "appears", "associated", "with", "Hispanic", "and", "Native", "American", "populations", "."], "h": {"id": "C1825709", "name": "C1825709#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [11, 12]}}
{"token": ["PhIP", "was", "preferentially", "metabolized", "by", "N2-hydroxylation", "in", "C1620185#ent", "<e1>", "whereas", "in", "C2987364#ent", "<e2>", "4'-hydroxylation", "was", "the", "predominant", "pathway", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [11, 12]}}
{"token": ["The", "role", "of", "microbial", "lipopolysaccharides", "(", "C0175697#ent", "<e1>", ")", "in", "the", "aetiopathogenesis", "of", "C0038013#ent", "<e2>", "AS", ")", "is", "a", "matter", "of", "continuing", "debate", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [13, 14]}}
{"token": ["Two", "patients", "had", "an", "early", "rash", "one", "showed", "a", "C0015230#ent", "<e1>", "one", "had", "a", "C0015230#ent", "<e1>", "symptoms", "of", "initial", "C0030807#ent", "<e1>", "and", "drug-induced", "LES", "(", "presence", "of", "antinuclear", "and", "anti-dsDNA", "antibodies", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030807", "name": "C0030807#ent", "pos": [19, 20]}}
{"token": ["Upstream", "of", "the", "C1332809#ent", "<e1>", "ILTV", "the", "C-terminal", "part", "an", "additional", "C0013570#ent", "<e2>", "designated", "as", "ULO", "was", "identified", ",", "which", "exhibits", "no", "significant", "homology", "to", "known", "herpesvirus", "genes"], "h": {"id": "C1332809", "name": "C1332809#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [11, 12]}}
{"token": ["C0025668#ent", "<e1>", "is", "a", "useful", "alternative", "to", "C0004745#ent", "<e2>", "for", "short-duration", "barbiturate", "anesthesia", "Greyhounds", "."], "h": {"id": "C0025668", "name": "C0025668#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0004745", "name": "C0004745#ent", "pos": [7, 8]}}
{"token": ["As", "for", "side", "effects", "there", "was", "a", "significantly", "lower", "frequency", "of", "dry", "mouth", "insomnia", "with", "C0078849#ent", "<e1>", "when", "compared", "with", "C0039955#ent", "<e2>", "."], "h": {"id": "C0078849", "name": "C0078849#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0039955", "name": "C0039955#ent", "pos": [20, 21]}}
{"token": ["Systemic", "corticosteroids", "therapy", "central", "to", "the", "management", "of", "C0582415#ent", "<e1>", "use", "of", "C0038317#ent", "<e2>", "also", "be", "beneficial", "in", "this", "setting", "."], "h": {"id": "C0582415", "name": "C0582415#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [12, 13]}}
{"token": ["The", "use", "of", "biologic", "markers", "aids", "in", "diagnosing", "depression", "and", "in", "predicting", "response", "to", "specific", "C0003289#ent", "<e1>", "discussed", ",", "and", "monitoring", "therapeutic", "response", "plasma", "C3536819#ent", "<e2>", "levels", "is", "reviewed", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [15, 16]}, "relation": "therapeutic_class_of", "t": {"id": "C3536819", "name": "C3536819#ent", "pos": [24, 25]}}
{"token": ["C0010592#ent", "<e1>", "CsA", ")", "causes", "distal", "renal", "tubular", "acidosis", "C1333340#ent", "<e2>", ")", "in", "humans", "and", "rodents", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333340", "name": "C1333340#ent", "pos": [9, 10]}}
{"token": ["Dopamine", "replacement", "therapies", "levodopa", ",", "dopamine", "receptor", "agonists", "anticholinergics", ",", "C3653412#ent", "<e1>", "and", "catechol-O-methyltransferase", "inhibitors", "remain", "the", "cornerstones", "of", "therapeutic", "interventions", "Parkinson's", "disease", "C3160718#ent", "<e2>", ")", "."], "h": {"id": "C3653412", "name": "C3653412#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [23, 24]}}
{"token": ["Such", "levels", "are", "sufficiently", "high", "to", "suggest", "a", "role", "in", "the", "C1414672#ent", "<e1>", "of", "neurological", "symptoms", "anemia", "and", "C0035086#ent", "<e2>"], "h": {"id": "C1414672", "name": "C1414672#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [18, 19]}}
{"token": ["Experiments", "performed", "in", "the", "presence", "of", "1", "microM", "phorbol", "12-myristate", "13-acetate", "PMA", ")", "indicated", "that", "C1259877#ent", "<e1>", "PKC", ")", "mediated", "the", "insulin", "effect", "C0538269#ent", "<e2>", ",", "but", "not", "on", "PC-PLD", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0538269", "name": "C0538269#ent", "pos": [23, 24]}}
{"token": ["We", "previously", "reported", "that", "interleukin-1alpha", "(IL-1alpha)-induced", "activation", "of", "C1259877#ent", "<e1>", "PKC", ")", "via", "phosphatidylcholine-specific", "phospholipase", "C", "C0538269#ent", "<e2>", ")", "limits", "IL-6", "synthesis", "induced", "by", "IL-1alpha", "itself", "in", "osteoblast-like", "MC3T3-E1", "cells", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0538269", "name": "C0538269#ent", "pos": [16, 17]}}
{"token": ["Use", "of", "an", "effective", "C0003374#ent", "<e1>", "(", "MQ", ")", "was", "protective", "against", "C0456065#ent", "<e2>", "through", "its", "effect", "on", "reducing", "placental", "and", "umbilical", "cord", "blood", "malaria", "infection", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0456065", "name": "C0456065#ent", "pos": [12, 13]}}
{"token": ["At", "the", "age", "of", "7.5", "years", ",", "unexpected", "C0018989#ent", "<e1>", "speech", "disability", "that", "seen", "in", "C0162671#ent", "<e2>", ",", "from", "which", "he", "recovered", "within", "1.5", "days", "."], "h": {"id": "C0018989", "name": "C0018989#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0162671", "name": "C0162671#ent", "pos": [15, 16]}}
{"token": ["Multiple", "stroke-like", "episodes", "C0018989#ent", "<e1>", "followed", ",", "indicating", "progression", "from", "a", "MERRF", "to", "a", "C0162671#ent", "<e2>", "phenotype", "."], "h": {"id": "C0018989", "name": "C0018989#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0162671", "name": "C0162671#ent", "pos": [14, 15]}}
{"token": ["TNFalpha", "treatment", "induced", "eIF2alpha", "phosphorylation", "and", "activation", "of", "C0291573#ent", "<e1>", "through", "the", "dsRNA-activated", "eIF2alpha", "kinase", "C0058980#ent", "<e2>", "."], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [15, 16]}}
{"token": ["These", "estrogen-dependent", "carcinomas", "considered", "to", "have", "a", "common", "characteristic", "in", "estrogen", "metabolism", "i.e.", ",", "the", "expression", "of", "C1366496#ent", "<e1>", "in", "the", "stromal", "cells", "of", "C0000165#ent", "<e2>", "the", "epithelial", "cells", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0000165", "name": "C0000165#ent", "pos": [24, 25]}}
{"token": ["C0022616#ent", "<e1>", "antagonized", "the", "C4255305#ent", "<e2>", "actions", "of", "5-HT", "but", "inhibition", "was", "not", "dose-related", "."], "h": {"id": "C0022616", "name": "C0022616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [4, 5]}}
{"token": ["The", "inhibition", "by", "C0022616#ent", "<e1>", "of", "the", "various", "C4255305#ent", "<e2>", "and", "platelet-aggregating", "effects", "of", "serotonin", "presumably", "contributes", "to", "the", "therapeutic", "effects", "the", "compound", "."], "h": {"id": "C0022616", "name": "C0022616#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [8, 9]}}
{"token": ["Previous", "studies", "have", "demonstrated", "that", "cytochrome", "P450", "2E1", "C3887686#ent", "<e1>", "catalyzes", "the", "oxidation", "of", "C0001002#ent", "<e2>", "in", "vitro"], "h": {"id": "C3887686", "name": "C3887686#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [14, 15]}}
{"token": ["Previous", "studies", "have", "demonstrated", "that", "C3887686#ent", "<e1>", "P450", "2E1", "catalyzes", "the", "oxidation", "of", "C0001002#ent", "<e2>", "in", "vitro"], "h": {"id": "C3887686", "name": "C3887686#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [13, 14]}}
{"token": ["Induction", "of", "P450", "isoenzymes", "IA", "IIB", "and", "C3887686#ent", "<e1>", "by", "pretreatment", "of", "mice", "with", "phenobarbitone", ",", "3-methylcholanthrene", "or", "C0001002#ent", "<e2>", "had", "no", "significant", "effect", "on", "the", "toxicity", "of", "4-HA", "towards", "hepatocytes", "."], "h": {"id": "C3887686", "name": "C3887686#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [18, 19]}}
{"token": ["The", "disruption", "of", "the", "cell", "cycle", "by", "changing", "the", "activity", "of", "C1430988#ent", "<e1>", "delayed", "gastrulation", "after", "C1335267#ent", "<e2>", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335267", "name": "C1335267#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "C1430988#ent", "<e1>", "began", "to", "localize", "to", "the", "plasma", "membranes", "nuclei", "at", "C1335267#ent", "<e2>", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335267", "name": "C1335267#ent", "pos": [14, 15]}}
{"token": ["Since", "there", "has", "been", "an", "increase", "in", "the", "number", "of", "patients", "suffering", "from", "C0039128#ent", "<e1>", "during", "the", "last", "2", "decades", ",", "C0027927#ent", "<e2>", "has", "to", "be", "seriously", "considered", "in", "many", "unclear", "neurological", "cases"], "h": {"id": "C0039128", "name": "C0039128#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0027927", "name": "C0027927#ent", "pos": [21, 22]}}
{"token": ["Limb", "girdle", "myasthenic", "syndromes", "rare", "genetic", "disorders", "under", "the", "broad", "heterogeneous", "group", "as", "C1864233#ent", "<e1>", "present", "with", "mixed", "features", "of", "myasthenia", "and", "C0026848#ent", "<e2>", "."], "h": {"id": "C1864233", "name": "C1864233#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [22, 23]}}
{"token": ["BN-063", "converted", "the", "C0042510#ent", "<e1>", "induced", "by", "C0282211#ent", "<e2>", "to", "normal", "sinus", "rhythm", "and", "improved", "the", "survival", "rate"], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [7, 8]}}
{"token": ["When", "all", "three", "C0243192#ent", "<e1>", "were", "combined", ",", "the", "C1333570#ent", "<e2>", "dose-response", "curve", "left", "shifted", "by", "about", "two", "orders", "of", "magnitude", "(", "from", "ED50", "of", "9", "ng/ml", "to", "0.1", "ng/ml", ")", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "efficacy", "and", "tolerability", "of", "C0377265#ent", "<e1>", "(", "LEV", ")", "monotherapy", "in", "C0270853#ent", "<e2>", "JME", ")", "."], "h": {"id": "C0377265", "name": "C0377265#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0270853", "name": "C0270853#ent", "pos": [20, 21]}}
{"token": ["C0032453#ent", "<e1>", "can", "be", "associated", "with", "C0009326#ent", "<e2>", "as", "systemic", "lupus", "erythematosus", "rheumatoid", "arthritis", "systemic", "vasculitis"], "h": {"id": "C0032453", "name": "C0032453#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [6, 7]}}
{"token": ["C0032453#ent", "<e1>", "RP", ")", "is", "not", "a", "totally", "rare", "C0009326#ent", "<e2>"], "h": {"id": "C0032453", "name": "C0032453#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [9, 10]}}
{"token": ["Erectile", "dysfunction", "may", "signal", "serious", "underlying", "and", "potential", "life-threatening", "diseases", ",", "such", "as", "C0011849#ent", "<e1>", ",", "hypertension", ",", "cardiovascular", "disease", "peripheral", "vascular", "disease", "and", "other", "neurologic", "and", "C0014130#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [27, 28]}}
{"token": ["We", "have", "identified", "cis-acting", "elements", "and", "trans-acting", "factors", "regulate", "C0907533#ent", "<e1>", "expression", "of", "the", "human", "C0003438#ent", "<e2>"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [15, 16]}}
{"token": ["Extracellular", "calcium", "uptake", "blocked", "by", "the", "calcium", "channel", "blockers", "lanthanum", "C0282138#ent", "<e1>", ",", "nifedipine", ",", "and", "C0211011#ent", "<e2>", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0211011", "name": "C0211011#ent", "pos": [16, 17]}}
{"token": ["C0282138#ent", "<e1>", "decreased", "the", "Vmax", "of", "the", "high-affinity", "channels", ",", "whereas", "C0211011#ent", "<e2>", "mibefradil", "influenced", "exclusively", "the", "Vmax", "of", "the", "low-affinity", "channels", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0211011", "name": "C0211011#ent", "pos": [11, 12]}}
{"token": ["C(4", ")", "photosynthetic", "C0014442#ent", "<e1>", "can", "accumulate", "in", "both", "bundle", "sheath", "mesophyll", "cells", "the", "absence", "of", "C1824309#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1824309", "name": "C1824309#ent", "pos": [16, 17]}}
{"token": ["C0018802#ent", "<e1>", "successfully", "treated", "with", "digitalis", ",", "diuretics", "and", "C0006938#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [9, 10]}}
{"token": ["In", "patients", "with", "symptomatic", "C0018802#ent", "<e1>", "losartan", "compared", "to", "C0006938#ent", "<e2>", "increased", "survival", "with", "better", "tolerability", "at", "a", "cost", "well", "within", "the", "range", "accepted", "as", "cost-effective", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [9, 10]}}
{"token": ["C1979930#ent", "<e1>", "MAP", ")", "kinases", "are", "activated", "by", "dual-specificity", "kinases", "termed", "C0752313#ent", "<e2>", "."], "h": {"id": "C1979930", "name": "C1979930#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [11, 12]}}
{"token": ["C1872963#ent", "<e1>", "is", "a", "novel", "orally", "active", "C0003374#ent", "<e2>", "."], "h": {"id": "C1872963", "name": "C1872963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [7, 8]}}
{"token": ["Second", ",", "we", "analyzed", "the", "ability", "of", "C2987364#ent", "<e1>", "HPV-6", "E7", "destabilize", "the", "other", "pRB", "family", "members", "C2984536#ent", "<e2>", "and", "p130", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2984536", "name": "C2984536#ent", "pos": [17, 18]}}
{"token": ["In", "cells", "expressing", "C2987364#ent", "<e1>", "TAg", ",", "only", "un(der)phosphorylated", "p130", "and", "C2984536#ent", "<e2>", "were", "detected", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2984536", "name": "C2984536#ent", "pos": [11, 12]}}
{"token": ["Skin", "biopsy", "as", "psoriasiform", "dermatitis", "nonspecific", "C0011603#ent", "<e1>", ",", "rather", "than", "C0033860#ent", "<e2>", ",", "should", "be", "considered", "a", "possible", "result", "of", "malignancy", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [11, 12]}}
{"token": ["Neuronal", "damage", "Alzheimer's", "disease", "AD", ")", "is", "thought", "to", "involve", "direct", "toxicity", "of", "C0078939#ent", "<e1>", "Abeta", ")", "and", "excitotoxicity", "involving", "NMDA", "receptors", "C0022614#ent", "<e2>", ")", "and", "altered", "Ca(2+)", "."], "h": {"id": "C0078939", "name": "C0078939#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [22, 23]}}
{"token": ["We", "describe", "the", "case", "of", "a", "38-year-old", "man", "with", "typical", "C0242292#ent", "<e1>", "the", "unusual", "combination", "of", "both", "growth-hormone", "and", "C0020514#ent", "<e2>"], "h": {"id": "C0242292", "name": "C0242292#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [19, 20]}}
{"token": ["These", "results", "confirmed", "that", "IFN-gamma", "activated", "C0662760#ent", "<e1>", "via", "JAK1/2", "phosphorylation", "to", "induce", "C3539645#ent", "<e2>", ",", "c-Src", ",", "STAT1", "activation", ",", "and", "ICAM-1", "expression", "."], "h": {"id": "C0662760", "name": "C0662760#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [13, 14]}}
{"token": ["Two", "types", "of", "bisphosphonates", "(", "BPs", ")", ",", "C1881172#ent", "<e1>", "(", "INC", ")", "and", "C0037507#ent", "<e2>", "(", "ETI", ")", "accelerated", "phosphate", "(Pi)-primed", "mineralization", "of", "MC4", "cells", "in", "a", "subnanomolar", "dose", "range", "."], "h": {"id": "C1881172", "name": "C1881172#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037507", "name": "C0037507#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "both", "SHIP2", "and", "C1416447#ent", "<e1>", "were", "coprecipitated", "with", "Fc", "gammaRIIB1", "'", "upon", "coaggregation", "with", "C0105421#ent", "<e2>", "in", "IIA1.6", "transfectants", "."], "h": {"id": "C1416447", "name": "C1416447#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [16, 17]}}
{"token": ["Other", "drugs", "which", "may", "be", "useful", "in", "relieving", "back", "pain", "associated", "with", "circumstances", "include", "the", "tricyclic", "antidepressants", "anxiolytics", ",", "antiepileptic", "agents", "C3540725#ent", "<e1>", ",", "colchicine", "and", "C0008736#ent", "<e2>", "."], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0008736", "name": "C0008736#ent", "pos": [26, 27]}}
{"token": ["We", "have", "shown", "that", "WIP", "interacts", "with", "members", "of", "the", "C0043194#ent", "<e1>", "protein", "family", "is", "essential", "for", "filopodium", "formation", "regulated", "by", "C1366537#ent", "<e2>", "GTPase", "."], "h": {"id": "C0043194", "name": "C0043194#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366537", "name": "C1366537#ent", "pos": [21, 22]}}
{"token": ["Gaucher", "disease", "a", "typical", "C0085078#ent", "<e1>", "resulting", "from", "an", "C0392207#ent", "<e2>", "glucocerebrosidase", "."], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0392207", "name": "C0392207#ent", "pos": [9, 10]}}
{"token": ["Surprisingly", ",", "activation", "of", "C0033036#ent", "<e1>", "with", "an", "agonistic", "antibody", "specific", "for", "C1539081#ent", "<e2>", "could", "not", "substitute", "for", "CD4(+", ")", "help", "in", "this", "task", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539081", "name": "C1539081#ent", "pos": [12, 13]}}
{"token": ["Two", "point", "mutations", "were", "identified", "within", "the", "C0079429#ent", "<e1>", "encoding", "bovine", "C3889161#ent", "<e2>", "in", "a", "Holstein", "calf", "afflicted", "with", "leukocyte", "adhesion", "deficiency", "LAD", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889161", "name": "C3889161#ent", "pos": [11, 12]}}
{"token": ["Because", "TJ-9", "'s", "macrobiotic", "effect", "in", "C0023890#ent", "<e1>", "patients", "has", "been", "proven", "statistically", "in", "an", "etiological", "study", "C1138012#ent", "<e2>", "could", "be", "a", "new", "important", "therapy", "in", "chronic", "liver", "diseases"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1138012", "name": "C1138012#ent", "pos": [17, 18]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "the", "in", "vitro", "production", "of", "IL-12", "by", "circulating", "mononuclear", "cells", "C0023890#ent", "<e1>", "patients", "and", "the", "effects", "of", "C1138012#ent", "<e2>", "on", "IL-12", "production", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1138012", "name": "C1138012#ent", "pos": [24, 25]}}
{"token": ["To", "determine", "which", "elements", "regulate", "functional", "C1334905#ent", "<e1>", "expression", ",", "the", "promoter", "regions", "human", "and", "mouse", "C1334905#ent", "<e1>", "C1417679#ent", "<e1>", "were", "cloned", "and", "characterized", "."], "h": {"id": "C1334905", "name": "C1334905#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["In", "summary", ",", "two", "C1334905#ent", "<e1>", "and", "two", "nrp2", "C1417679#ent", "<e2>", ",", "with", "expression", "patterns", "similar", "to", "higher", "vertebrates", ",", "have", "been", "isolated", "from", "zebrafish", "."], "h": {"id": "C1334905", "name": "C1334905#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}}
{"token": ["C0013404#ent", "<e1>", "was", "the", "most", "common", "symptom", "in", "constrictive", "cardiomyopathy", "C1861861#ent", "<e2>", ")", "."], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1861861", "name": "C1861861#ent", "pos": [10, 11]}}
{"token": ["Electroporation", "of", "C0669365#ent", "<e1>", "active", "V14RhoA", "and", "V12Rac1", "recombinant", "proteins", "TK-1", "cells", "that", "both", "C0084340#ent", "<e2>", "and", "Rac1", "induce", "alpha4beta7", "adhesion", "to", "MAdCAM-1", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [14, 15]}}
{"token": ["Bacterial", "and", "C0747256#ent", "<e1>", "prevalent", "in", "Africa", ";", "C0033740#ent", "<e2>", "as", "toxoplasmosis", ",", "cryptosporidiosis", ",", "and", "isosporiasis", "are", "also", "common", "in", "Latin", "America"], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0033740", "name": "C0033740#ent", "pos": [8, 9]}}
{"token": ["The", "following", "antibacterial", "agents", "used", ":", "diamine", "silver", "fluoride", "C1427941#ent", "<e1>", ")", ";", "sodium", "fluoride", "NaF", ")", ";", "and", "C0885449#ent", "<e2>", "JJZ", ")", "."], "h": {"id": "C1427941", "name": "C1427941#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0885449", "name": "C0885449#ent", "pos": [19, 20]}}
{"token": ["Vanilloid", "Receptor", "1", "C1421467#ent", "<e1>", ")", ",", "a", "member", "of", "the", "C1705940#ent", "<e2>", "family", "of", "channels", ",", "is", "activated", "by", "noxious", "heat", "."], "h": {"id": "C1421467", "name": "C1421467#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [11, 12]}}
{"token": ["C0538674#ent", "<e1>", "of", "two", "structurally", "related", "isozymes", ",", "C1415619#ent", "<e2>", "and", "HO-2", "."], "h": {"id": "C0538674", "name": "C0538674#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [8, 9]}}
{"token": ["In", "the", "case", "of", "neurogenic", "inflammation", "where", "it", "is", "common", "for", "more", "than", "one", "biologically", "active", "to", "be", "released", "concomitantly", ",", "it", "may", "be", "more", "sensible", "to", "develop", "C0035064#ent", "<e1>", "that", "inhibit", "C1334960#ent", "<e2>"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1334960", "name": "C1334960#ent", "pos": [32, 33]}}
{"token": ["Messenger", "RNA", "C1704467#ent", "<e1>", "was", "detected", "after", "treatment", "with", "C0917964#ent", "<e2>", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [9, 10]}}
{"token": ["Sexually", "transmitted", "diseases", "C1421567#ent", "<e1>", ")", "are", "now", "the", "commonest", "group", "of", "notifiable", "C0005943#ent", "<e2>", "most", "countries", ",", "particularly", "in", "the", "age", "group", "15", "to", "50", "years", "and", "in", "infants", "."], "h": {"id": "C1421567", "name": "C1421567#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "C0033209#ent", "<e1>", "and", "C0010592#ent", "<e2>", "together", "were", "higher", "than", "the", "effect", "of", "either", "C0033209#ent", "<e1>", "or", "C0010592#ent", "<e2>", "alone", "on", "calcein-AM", "uptake", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [3, 4]}}
{"token": ["A", "slight", "increase", "in", "concentration", "of", "ATFX", "in", "plasma", "was", "observed", "after", "C0010592#ent", "<e1>", "A", ",", "erythromycin", ",", "C0033209#ent", "<e2>", "and", "cimetidine", "treatment", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [18, 19]}}
{"token": ["The", "entity", "of", "CMD", "was", "practically", "absent", "in", "the", "international", "classification", "C1832661#ent", "<e1>", "until", "1986", ",", "when", "MIM", "first", "enlisted", "C1414558#ent", "<e2>", "as", "a", "disease", "entity"], "h": {"id": "C1832661", "name": "C1832661#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414558", "name": "C1414558#ent", "pos": [20, 21]}}
{"token": ["C0079805#ent", "<e1>", "activation", "further", "boosts", "Cdc25", "and", "represses", "C1421500#ent", "<e2>", "."], "h": {"id": "C0079805", "name": "C0079805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421500", "name": "C1421500#ent", "pos": [8, 9]}}
{"token": ["We", "show", "that", "C0919432#ent", "<e1>", "can", "interact", "with", "a", "C-terminal", "fragment", "C1705458#ent", "<e2>", "in", "a", "temporal", "and", "phosphorylation-dependent", "manner", "."], "h": {"id": "C0919432", "name": "C0919432#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705458", "name": "C1705458#ent", "pos": [11, 12]}}
{"token": ["In", "G(M2", ")", "C0017083#ent", "<e1>", "variant", "0", ",", "a", "defect", "in", "the", "beta-subunit", "of", "C0005270#ent", "<e2>", "EC", "3.2.1.52", ")", "causes", "abnormal", "accumulation", "of", "G(M2", ")", "ganglioside", "and", "severe", "neurodegeneration", "."], "h": {"id": "C0017083", "name": "C0017083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005270", "name": "C0005270#ent", "pos": [14, 15]}}
{"token": ["Each", "species", "was", "able", "to", "grow", "anaerobically", "with", "C0077194#ent", "<e1>", ",", "nitrate", "or", "C0220833#ent", "<e2>", ",", "but", "not", "with", "DMSO", ",", "as", "an", "electron", "acceptor"], "h": {"id": "C0077194", "name": "C0077194#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0220833", "name": "C0220833#ent", "pos": [13, 14]}}
{"token": ["Osteoclasts", "express", "high", "levels", "of", "the", "C1307053#ent", "<e1>", "the", "defect", "responsible", "for", "the", "C0029454#ent", "<e2>", "phenotype", "of", "the", "c-src-deficient", "(", "src-", ")", "mouse", "is", "cell-autonomous", "and", "occurs", "in", "mature", "osteoclasts", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029454", "name": "C0029454#ent", "pos": [13, 14]}}
{"token": ["In", "the", "female", ",", "a", "gain-of-function", "experiment", "clearly", "demonstrated", "that", "C1421567#ent", "<e1>", "was", "the", "sole", "S", "determinant", ",", "and", "that", "C1539771#ent", "<e2>", "enhanced", "the", "SI", "recognition", "process", "."], "h": {"id": "C1421567", "name": "C1421567#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539771", "name": "C1539771#ent", "pos": [20, 21]}}
{"token": ["The", "antigen-presenting", "cells", "for", "TS1", "induction", "lack", "the", "Thy-1", "and", "C1704849#ent", "<e1>", "markers", ",", "and", "are", "resistant", "to", "500", "R", "irradiation", "to", "C0010583#ent", "<e2>", "treatment", "."], "h": {"id": "C1704849", "name": "C1704849#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [22, 23]}}
{"token": ["Moreover", ",", "many", "people", "suffer", "from", "C0015230#ent", "<e1>", "hyperpigmentation", ",", "which", "is", "considered", "to", "be", "a", "C0037274#ent", "<e2>", "causes", "psychological", "disturbance"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [16, 17]}}
{"token": ["We", "have", "examined", "two", "C0017363#ent", "<e1>", "Papillon-Lef\u00e8vre", "syndrome", "and", "evaluated", "the", "gene", "encoding", "C1413811#ent", "<e2>", "mutations", "."], "h": {"id": "C0017363", "name": "C0017363#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413811", "name": "C1413811#ent", "pos": [13, 14]}}
{"token": ["We", "further", "demonstrate", "that", "C1334894#ent", "<e1>", "and", "NuMA", "interact", "with", "C3639972#ent", "<e2>", "and", "NuMA-RARalpha", ",", "respectively", "."], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [4, 5]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3639972", "name": "C3639972#ent", "pos": [10, 11]}}
{"token": ["We", "also", "observed", "nuclear", "co-localization", "C1334894#ent", "<e1>", ",", "RXRalpha", ",", "and", "C3639972#ent", "<e2>", "in", "these", "cells", "."], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [5, 6]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3639972", "name": "C3639972#ent", "pos": [11, 12]}}
{"token": ["Ranked", "on", "perceived", "economic", "importance", ",", "producers", "cited", "trauma", ",", "C0043046#ent", "<e1>", "calf", "scours", ",", "dystocia", ",", "pneumonia", ",", "winter", "tick", "C0041296#ent", "<e2>", ",", "and", "grain", "overload"], "h": {"id": "C0043046", "name": "C0043046#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [21, 22]}}
{"token": ["It", "is", "concluded", "that", "a", "C1283601#ent", "<e1>", "a", "factor", "in", "the", "causation", "of", "ichthyosis", "of", "the", "C0678928#ent", "<e2>", "inherited", "type", "."], "h": {"id": "C1283601", "name": "C1283601#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [16, 17]}}
{"token": ["Expression", "analysis", "the", "protein", "tyrosine", "kinases", "C1366894#ent", "<e1>", "FAK", ")", "and", "C0380871#ent", "<e2>", "Pyk2", ")", "in", "high", "grade", "osteosarcomas", "."], "h": {"id": "C1366894", "name": "C1366894#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0380871", "name": "C0380871#ent", "pos": [11, 12]}}
{"token": ["2", "cases", "of", "C0149904#ent", "<e1>", "to", "preajmaline", "recovered", "when", "the", "C0013227#ent", "<e2>", "was", "stopped", "."], "h": {"id": "C0149904", "name": "C0149904#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["The", "clinical", ",", "biochemical", ",", "and", "histopathological", "characteristics", "are", "those", "of", "a", "C0149904#ent", "<e1>", "resolves", "on", "withdrawal", "of", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C0149904", "name": "C0149904#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [19, 20]}}
{"token": ["A", "peer-reviewed", "and", "published", "Markov", "model", "was", "used", "to", "simulate", "progression", "from", "microalbuminuria", "to", "overt", "C0017661#ent", "<e1>", ",", "doubling", "of", "serum", "creatinine", "C0035078#ent", "<e2>", "and", "all-cause", "mortality", "in", "hypertensive", "patients", "with", "type", "2", "diabetes"], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [22, 23]}}
{"token": ["C4284022#ent", "<e1>", "of", "patients", "with", "tuberculosis", "exhibited", "an", "increased", "C4049859#ent", "<e2>", "and", "a", "significantly", "increased", "expression", "of", "co-stimulatory", "molecules", "with", "controls", "."], "h": {"id": "C4284022", "name": "C4284022#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [9, 10]}}
{"token": ["C1522507#ent", "<e1>", "is", "a", "unique", "C3540579#ent", "<e2>", "CX3C", "chemokine", "to", "induce", "adhesion", "and", "migration", "of", "leukocytes", "mediated", "by", "both", ",", "a", "membrane-bound", "and", "soluble", "form", ",", "respectively", "."], "h": {"id": "C1522507", "name": "C1522507#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [5, 6]}}
{"token": ["Twelve", "men", "with", "severe", "and", "long-standing", "C0011615#ent", "<e1>", "admitted", "to", "a", "double-blind", "trial", "establish", "the", "effects", "of", "C0041031#ent", "<e2>", "trimipramine", "maleate", ",", "and", "placebo", "on", "nocturnal", "scratching"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0041031", "name": "C0041031#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "biochemical", "parameters", "(", "BUN", ",", "C0004002#ent", "<e1>", ",", "LDH", "and", "C1709111#ent", "<e2>", ")", "were", "examined", "using", "plasma", "and", "urine", "samples"], "h": {"id": "C0004002", "name": "C0004002#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1709111", "name": "C1709111#ent", "pos": [13, 14]}}
{"token": ["These", "studies", "provide", "the", "first", "experimental", "evidence", "that", "COX-2", "inhibition", "with", "C0132515#ent", "<e1>", "is", "able", "to", "limit", "BBB", "disruption", "and", "leukocyte", "infiltration", "transient", "C0917798#ent", "<e2>"], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [23, 24]}}
{"token": ["CONCLUSIONS", ":", "These", "data", "show", "that", "C0132515#ent", "<e1>", "protects", "against", "permanent", "C0917798#ent", "<e2>", "even", "with", "a", "2", "h", "post-treatment", "delay", "."], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [11, 12]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "evaluate", "the", "neuroprotective", "effects", "the", "selective", "COX-2", "inhibitor", "C0132515#ent", "<e1>", "on", "cerebral", "infarction", "neurological", "deficits", "a", "standardized", "model", "of", "transient", "C0917798#ent", "<e2>", "rats", "."], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [27, 28]}}
{"token": ["Chronic", "treatment", "muscimol", "did", "not", "affect", "levels", "of", "subunit", "mRNAS", "alpha", "1-", "or", "C1333687#ent", "<e1>", "GABAA", "receptors", "chronic", "flunitrazepam", "not", "affect", "subunit", "mRNAs", "or", "C2362546#ent", "<e2>"], "h": {"id": "C1333687", "name": "C1333687#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2362546", "name": "C2362546#ent", "pos": [24, 25]}}
{"token": ["The", "progress", "of", "the", "reaction", "was", "analyzed", "in", "quenched", "samples", "by", "immunoassay", "and", "immunoblotting", "for", "fibrinopeptide", "A", "FPA", ")", ",", "C0052128#ent", "<e1>", ",", "factor", "V", "activation", ",", "and", "C1420342#ent", "<e2>", "."], "h": {"id": "C0052128", "name": "C0052128#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [28, 29]}}
{"token": ["Anti-phospholipid", "antibodies", "found", "in", "children", "complicated", "by", "myocardial", "infarction", "pulmonary", "hypertension", "C0151445#ent", "<e1>", "phenomenon", ",", "cerebral", "and", "C0024138#ent", "<e2>"], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [17, 18]}}
{"token": ["The", "overflow", "of", "C2744579#ent", "<e1>", "was", "decreased", "by", "C0032912#ent", "<e2>", "but", "not", "diminished", "further", "after", "additional", "desensitization", "by", "alpha", ",", "beta-methylene", "ATP", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [8, 9]}}
{"token": ["There", "was", ",", "however", ",", "a", "relatively", "low", "frequency", "of", "C0238339#ent", "<e1>", "0", "which", "may", "be", "related", "to", "the", "low", "C0024530#ent", "<e2>", "parasite", "prevalence", "in", "this", "group", "."], "h": {"id": "C0238339", "name": "C0238339#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [20, 21]}}
{"token": ["Of", "those", "with", "C1704321#ent", "<e1>", "five", "had", "C0027721#ent", "<e2>", "nine", "focal", "glomerular", "sclerosis", "six", "membraneous", "nephropathy", "three", "amyloidosis", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [7, 8]}}
{"token": ["We", "report", "a", "72-year-old", "man", "with", "C1704321#ent", "<e1>", "to", "minimal", "C0027721#ent", "<e2>", "an", "accurate", "seek", "of", "underlying", "malignancy", "revealed", "a", "cecum", "adenocarcinoma"], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [10, 11]}}
{"token": ["Reporting", "a", "rare", "case", "with", "Kimura's", "disease", "angiolymphoid", "hyperplasia", "eosinophilia", "(", "ALHE", ")", ",", "who", "also", "has", "C1704321#ent", "<e1>", "from", "minimal", "C0027721#ent", "<e2>"], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [21, 22]}}
{"token": ["Monoacylglycerol", "lipase", "separated", "from", "C0023764#ent", "<e1>", "two", "kinds", "of", "C0014894#ent", "<e2>", "in", "the", "microsomes", "by", "heparin", "treatment", "and", "DEAE-cellulose", "column", "chromatography"], "h": {"id": "C0023764", "name": "C0023764#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0014894", "name": "C0014894#ent", "pos": [9, 10]}}
{"token": ["We", "report", "two", "cases", "of", "C0178879#ent", "<e1>", "fungal", "bezoars", "in", "full-term", "neonates", "who", "presented", "a", "C0042075#ent", "<e2>", "detected", "antenatally", "."], "h": {"id": "C0178879", "name": "C0178879#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", "both", "intravenous", "ouabain", "and", "maintenance", "treatment", "C0012265#ent", "<e1>", "a", "modest", "positive", "inotropic", "effect", "patients", "with", "C0018802#ent", "<e2>", "sinus", "rhythm"], "h": {"id": "C0012265", "name": "C0012265#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [18, 19]}}
{"token": ["The", "death", "of", "a", "23-year-old", "man", "resulting", "from", "C0012265#ent", "<e1>", "toxicity", "and", "C0018802#ent", "<e2>", "attributed", "to", "ingestion", "of", "a", "West", "Indian", "aphrodisiac", "known", "as", "\"", "Love", "Stone"], "h": {"id": "C0012265", "name": "C0012265#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}}
{"token": ["The", "PC-1", "protein", "has", "an", "overall", "structure", "membrane", "orientation", "resembles", "those", "of", "the", "transferrin", "receptor", "the", "C1412578#ent", "<e1>", "and", "the", "C1413237#ent", "<e2>"], "h": {"id": "C1412578", "name": "C1412578#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413237", "name": "C1413237#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "support", "the", "notion", "that", "although", "both", "C1417685#ent", "<e1>", "and", "vascular", "changes", "occur", "in", "C1832903#ent", "<e2>", "the", "former", "seems", "to", "be", "a", "more", "likely", "explanation", "for", "the", "neurological", "deficits"], "h": {"id": "C1417685", "name": "C1417685#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1832903", "name": "C1832903#ent", "pos": [15, 16]}}
{"token": ["Hypaconitine", "(", "C0062773#ent", "<e1>", ")", "was", "more", "potent", "than", "C0001159#ent", "<e2>", "(", "ATN", ")", ",", "mesaconitine", "(", "MAT", ")", "and", "deoxyaconitine", "."], "h": {"id": "C0062773", "name": "C0062773#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001159", "name": "C0001159#ent", "pos": [9, 10]}}
{"token": ["Consistently", ",", "silencing", "of", "SUMO1", "led", "to", "recruitment", "of", "C1704743#ent", "<e1>", "and", "release", "of", "C1333891#ent", "<e2>", "at", "the", "C1704743#ent", "<e1>", "target", "promoters", ",", "and", "subsequent", "transcriptional", "activation", "the", "C1704743#ent", "<e1>", "target", "genes", "."], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1704743", "name": "C1704743#ent", "pos": [9, 10]}}
{"token": ["C1417172#ent", "<e1>", "has", "been", "shown", "to", "reside", "downstream", "of", "the", "macrophage", "colony-stimulating", "factor", "C1332789#ent", "<e2>", ")", "and", "receptor", "activator", "of", "NF-kappaB", "ligand", "RANKL", ")", "signaling", "pathways", "are", "critical", "for", "osteoclast", "proliferation", "differentiation", "and", "function", "."], "h": {"id": "C1417172", "name": "C1417172#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332789", "name": "C1332789#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "we", "prepared", "hippocampal", "slice", "cultures", "from", "C1415042#ent", "<e1>", "and", "GFAP+/+", "mice", "and", "compared", "their", "astrocytic", "responses", "injected", "C1822725#ent", "<e2>", "."], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1822725", "name": "C1822725#ent", "pos": [19, 20]}}
{"token": ["Arylsulfatase", "A", "to", "the", "C1426909#ent", "<e1>", "members", "carry", "a", "C1999492#ent", "<e2>", "that", "is", "post-translationally", "generated", "by", "oxidation", "of", "a", "conserved", "cysteine", "or", "serine", "residue"], "h": {"id": "C1426909", "name": "C1426909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1999492", "name": "C1999492#ent", "pos": [9, 10]}}
{"token": ["Arylsulfatase", "A", "ASA", ")", "belongs", "to", "the", "C1426909#ent", "<e1>", "members", "carry", "a", "C1999492#ent", "<e2>", "that", "is", "post-translationally", "generated", "by", "oxidation", "of", "a", "conserved", "cysteine", "or", "serine", "residue"], "h": {"id": "C1426909", "name": "C1426909#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1999492", "name": "C1999492#ent", "pos": [12, 13]}}
{"token": ["C2697656#ent", "<e1>", "suppressed", "the", "colony-forming", "activity", "much", "as", "C0085752#ent", "<e2>", "did", ",", "but", "it", "showed", "only", "cytostatic", "effects", "cell", "proliferation", "assay"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [8, 9]}}
{"token": ["It", "was", "the", "objective", "of", "this", "study", "to", "determine", "whether", "[", "des-Gly10", ",", "D-Trp6]LHRH", "ethylamide", ",", "an", "C1706334#ent", "<e1>", "agonist", "known", "as", "C0083220#ent", "<e2>", ",", "is", "degraded", "by", "the", "rabbit", "conjunctiva", "."], "h": {"id": "C1706334", "name": "C1706334#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0083220", "name": "C0083220#ent", "pos": [22, 23]}}
{"token": ["These", "results", "indicate", "that", "in", "patients", "with", "C0001363#ent", "<e1>", "markedly", "increased", "in", "vivo", "thrombin", "generation", "associated", "with", "unbalance", "between", "coagulant", "and", "C3536711#ent", "<e2>", "vitamin", "K-dependent", "factors"], "h": {"id": "C0001363", "name": "C0001363#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [21, 22]}}
{"token": ["C0108855#ent", "<e1>", "cdk2", ")", "and", "cyclin", "C1332733#ent", "<e2>", "activities", "were", "increased", ",", "and", "p27-associated", "kinase", "activity", "was", "detected", "in", "184A1L5(R", ")", "cells", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332733", "name": "C1332733#ent", "pos": [6, 7]}}
{"token": ["Senescent", "HUVEC", "contain", "undetectable", "C0108855#ent", "<e1>", "activity", ",", "which", "results", "from", "a", "dramatic", "reduction", "of", "C1332733#ent", "<e2>", "and", "inhibition", "of", "remaining", "C0108855#ent", "<e1>", "by", "p21(Cip1/Waf1", ")", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332733", "name": "C1332733#ent", "pos": [15, 16]}}
{"token": ["InvF", "then", "activates", "genes", "that", "encode", "C0086376#ent", "<e1>", "secreted", "by", "the", "C0919490#ent", "<e2>", "TTS", "apparatus", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [11, 12]}}
{"token": ["cDNA", "constructions", "used", "to", "generate", "C0086376#ent", "<e1>", "lacking", "portions", "of", "either", "the", "amino-", "or", "carboxy-terminal", "ends", "the", "C0919490#ent", "<e2>", "the", "DNA", "binding", "domain", "the", "highly", "basic", "carboxy-terminal", "domain", "the", "protein", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [17, 18]}}
{"token": ["Aplastic", "anemia", "pure", "red", "cell", "aplasia", "leukemia", ",", "lymphoma", "and", "other", "C0018939#ent", "<e1>", "followed", "exposure", "to", "products", "containing", "the", "pesticide", "pentachlorophenol", "C1418873#ent", "<e2>", ")", "."], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418873", "name": "C1418873#ent", "pos": [21, 22]}}
{"token": ["Quantitation", "by", "radiolabel", "and", "mass", "revealed", "equivalent", "elevations", "in", "C0031716#ent", "<e1>", "and", "choline", ",", "suggesting", "stimulation", "of", "both", "C0031671#ent", "<e2>", "phospholipase", "D", "activities", "."], "h": {"id": "C0031716", "name": "C0031716#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [18, 19]}}
{"token": ["While", "the", "expression", "of", "C1706544#ent", "<e1>", "and", "complement", "C3d", "detected", "using", "immuno-histochemistry", ",", "and", "C3540507#ent", "<e2>", "was", "detected", "semi-quantitatively", "with", "Western", "blot", "analysis", "the", "perihematomal", "area", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540507", "name": "C3540507#ent", "pos": [14, 15]}}
{"token": ["The", "roles", "of", "C0082529#ent", "<e1>", "ERK", ")", "activation", "and", "mitogen-activated", "protein", "kinase", "phosphatase-1", "C1333257#ent", "<e2>", ")", "were", "examined", "in", "sphingosine-1-phosphate", "(S1P)-mediated", "inhibition", "of", "apoptosis", "in", "C3H10", "T", "1/2", "fibroblast", "cells", "."], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333257", "name": "C1333257#ent", "pos": [13, 14]}}
{"token": ["To", "study", "these", "upstream", "mechanisms", "the", "C1366475#ent", "<e1>", "promoter", "was", "cloned", "into", "a", "C1334435#ent", "<e2>"], "h": {"id": "C1366475", "name": "C1366475#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334435", "name": "C1334435#ent", "pos": [13, 14]}}
{"token": ["In", "parallel", ",", "C1415321#ent", "<e1>", "GSK-3beta", ")", "inactivation", "and", "C1414352#ent", "<e2>", "4E-BP1", ")", "phosphorylation", "were", "monitored", "as", "markers", "of", "the", "rapamycin-insensitive", "and", "-sensitive", "branches", "of", "the", "PI3K", "signaling", "pathway", "respectively", "."], "h": {"id": "C1415321", "name": "C1415321#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414352", "name": "C1414352#ent", "pos": [9, 10]}}
{"token": ["In", "parallel", ",", "C1415321#ent", "<e1>", "GSK-3beta", ")", "inactivation", "and", "eukaryotic", "translation", "initiation", "factor", "4E-binding", "protein", "1", "C1414352#ent", "<e2>", ")", "phosphorylation", "were", "monitored", "as", "markers", "of", "the", "rapamycin-insensitive", "and", "-sensitive", "branches", "of", "the", "PI3K", "signaling", "pathway", "respectively", "."], "h": {"id": "C1415321", "name": "C1415321#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414352", "name": "C1414352#ent", "pos": [16, 17]}}
{"token": ["The", "C1414264#ent", "<e1>", "mutant", "does", "not", "constitutively", "express", "the", "pathogenesis-related", "genes", "C1706322#ent", "<e2>", ",", "BGL2", ",", "or", "PR-5", "and", "thus", "differs", "from", "previously", "described", "disease-resistant", "mutants", "of", "Arabidopsis", "."], "h": {"id": "C1414264", "name": "C1414264#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706322", "name": "C1706322#ent", "pos": [11, 12]}}
{"token": ["Injection", "of", "C1504688#ent", "<e1>", "fluorocitrate", ",", "a", "glial", "inhibitor", "attenuated", "C0020429#ent", "<e2>", "and", "NMDA", "receptor", "phosphorylation", "after", "inflammation", "."], "h": {"id": "C1504688", "name": "C1504688#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [10, 11]}}
{"token": ["This", "case", "illustrates", "the", "possibility", "that", "M.", "pneumoniae", "produce", "a", "predominantly", "C0752235#ent", "<e1>", "the", "need", "to", "include", "this", "infection", "in", "the", "differential", "diagnosis", "C0242567#ent", "<e2>", ",", "or", "polyradiculoneuritis", "."], "h": {"id": "C0752235", "name": "C0752235#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242567", "name": "C0242567#ent", "pos": [23, 24]}}
{"token": ["Because", "many", "patients", "with", "C0276609#ent", "<e1>", "detectable", "hepatitis", "B", "surface", "antigen", "HBsAg", ")", ",", "a", "radioimmunoassay", "for", "C1706005#ent", "<e2>", "antibody", "to", "hepatitis", "B", "core", "antigen", "anti-HBc", ")", "was", "developed", "and", "evaluated", "as", "a", "diagnostic", "test"], "h": {"id": "C0276609", "name": "C0276609#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [17, 18]}}
{"token": ["Ataxia", "with", "isolated", "Vit", "E", "deficiency", "AVED", ")", "is", "an", "Autosomal", "C0017361#ent", "<e1>", "a", "mutation", "in", "the", "alpha", "tocopherol", "transfer", "protein", "gene", "C1421223#ent", "<e2>", ")", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1421223", "name": "C1421223#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "GSTpi", "is", "involved", "in", "the", "C1425942#ent", "<e1>", "inhibition", "of", "C1367731#ent", "<e2>", "JNK", ")", ",", "a", "process", "that", "can", "be", "modulated", "by", "GST", "inhibitors"], "h": {"id": "C1425942", "name": "C1425942#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [11, 12]}}
{"token": ["The", "plant", "is", "also", "used", "to", "manufacture", "a", "sweet", "herbal", "infusion", "used", "for", "restorative", "properties", "such", "as", "C0010200#ent", "<e1>", "alleviating", "bronchial", "complaints", "including", "C0041323#ent", "<e2>", ",", "pneumonia", ",", "and", "catarrh", "."], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [23, 24]}}
{"token": ["In", "an", "8-year-old", "Somali", "girl", "had", "been", "in", "the", "Netherlands", "for", "3", "years", "and", "who", "was", "suffering", "from", "C0010200#ent", "<e1>", "for", "2", "months", ",", "C0041323#ent", "<e2>", "of", "the", "lung", "was", "diagnosed", "."], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [24, 25]}}
{"token": ["This", "paper", "reviews", "recent", "studies", "on", "the", "role", "of", "Nnt", "(", "C0027307#ent", "<e1>", "in", "insulin", "secretion", "detoxification", "of", "C0812281#ent", "<e2>", "(", "reactive", "oxygen", "species", "."], "h": {"id": "C0027307", "name": "C0027307#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [18, 19]}}
{"token": ["The", "r\u00f4le", "of", "C0162820#ent", "<e1>", "aeroallergens", "in", "C0015456#ent", "<e2>", "FD", ")", "was", "studied", "."], "h": {"id": "C0162820", "name": "C0162820#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015456", "name": "C0015456#ent", "pos": [7, 8]}}
{"token": ["The", "glomerular", "filtration", "rate", "the", "C3203102#ent", "<e1>", "clearance", "fell", "after", "high", "doses", "C0052820#ent", "<e2>", ",", "whilst", "the", "renal", "blood", "flow", "electromagnetically", "with", "a", "flow", "probe", "around", "the", "renal", "artery", "increased", "even", "at", "high", "doses"], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0052820", "name": "C0052820#ent", "pos": [12, 13]}}
{"token": ["Efforts", "to", "design", "C2987634#ent", "<e1>", "antagonists", "useful", "for", "treat-ing", "infertility", "and", "C3831153#ent", "<e2>", "would", "benefit", "from", "a", "molecular", "understanding", "of", "hormone-receptor", "interaction"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [11, 12]}}
{"token": ["Although", "C0031117#ent", "<e1>", "commonly", "observed", "in", "patients", "with", "non-Hodgkin's", "malignant", "lymphomas", "NHML", ")", ",", "C0018378#ent", "<e2>", "GBS", ")", "belongs", "to", "the", "occasional", "complications", "of", "lymphoproliferative", "disorders"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [14, 15]}}
{"token": ["A", "search", "should", "be", "made", "for", "C0041296#ent", "<e1>", "patients", "with", "C0558489#ent", "<e2>", "no", "obvious", "aetiology", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0558489", "name": "C0558489#ent", "pos": [10, 11]}}
{"token": ["Four", "cases", "of", "C0041296#ent", "<e1>", "with", "severe", "C0558489#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0558489", "name": "C0558489#ent", "pos": [7, 8]}}
{"token": ["Endo-M", ",", "C0086215#ent", "<e1>", "from", "Mucor", "hiemalis", "is", "known", "as", "a", "useful", "C0014442#ent", "<e2>", "for", "the", "synthesis", "of", "neoglycopeptides", "due", "to", "its", "transglycosylation", "activity"], "h": {"id": "C0086215", "name": "C0086215#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["Procathepsin", "C", "totally", "extracted", "by", "C0020554#ent", "<e1>", "whereas", "procathepsin", "D", "a", "membrane-associated", "form", "requiring", "C0146951#ent", "<e2>", "its", "extraction", "."], "h": {"id": "C0020554", "name": "C0020554#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [14, 15]}}
{"token": ["First", ",", "we", "showed", "that", "C1366572#ent", "<e1>", "and", "CCL21", ",", "chemokines", "involved", "in", "C1367452#ent", "<e2>", "formation", ",", "are", "overexpressed", "in", "MG", "thymus", "."], "h": {"id": "C1366572", "name": "C1366572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [13, 14]}}
{"token": ["When", "N", "formyl", "methionine", "leucyl", "phenylalanine", "C1705725#ent", "<e1>", ")", "was", "used", ",", "C0024141#ent", "<e2>", "PMN", "showed", "an", "O2-production", "of", "2.1", "nmol/min", "10(7", ")", "which", "is", "5-fold", "the", "response", "of", "normal", "PMN", "stimulated", "by", "C1705725#ent", "<e1>", "."], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [12, 13]}}
{"token": ["Lipoteichoic", "acid", "LTA", ")", ",", "extracted", "from", "Streptococcus", "mutans", "by", "hot", "aqueous", "C0031428#ent", "<e1>", ",", "was", "partially", "purified", "by", "Sepharose", "6B", "column", "chromatography", "0.01", "M", "C0142785#ent", "<e2>", "pH", "6.0", ",", "containing", "0.25", "M", "sodium", "chloride", "0.001", "M", "EDTA", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0142785", "name": "C0142785#ent", "pos": [25, 26]}}
{"token": ["Ongoing", "studies", "will", "demonstrate", "if", "activity", "of", "C0594375#ent", "<e1>", "can", "be", "enhanced", "when", "combined", "with", "alkylating", "agents", "including", "C0935694#ent", "<e2>", "and", "temozolomide", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0935694", "name": "C0935694#ent", "pos": [18, 19]}}
{"token": ["Activity", "assay", "that", "the", "insertion", "of", "C1708024#ent", "<e1>", ",", "RL", "and", "C1416867#ent", "<e2>", "linkers", "increased", "the", "anti-viral", "activity", "of", "fusion", "protein", "39", "%", ",", "68", "%", "and", "115", "%", ",", "respectively", "."], "h": {"id": "C1708024", "name": "C1708024#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [11, 12]}}
{"token": ["Antihypertensive", "therapy", "C0006684#ent", "<e1>", "but", "not", "with", "C0025741#ent", "<e2>", ")", "caused", "reduction", "of", "LV", "wall", "thickness", "but", "increased", "LV", "end-diastolic", "volume", "EDV", ")", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025741", "name": "C0025741#ent", "pos": [7, 8]}}
{"token": ["The", "sexually", "transmitted", "diseases", "C1420519#ent", "<e1>", ")", "correspond", "to", "bacterial", ",", "viral", ",", "mycotic", "and", "C0023897#ent", "<e2>"], "h": {"id": "C1420519", "name": "C1420519#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023897", "name": "C0023897#ent", "pos": [15, 16]}}
{"token": ["Diabetic", "patients", "frequently", "suffer", "from", "retinopathy", ",", "C0022658#ent", "<e1>", ",", "neuropathy", "and", "accelerated", "C0003850#ent", "<e2>", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [13, 14]}}
{"token": ["Vascular", "endothelial", "growth", "factor", "VEGF", ")", "and", "basic", "fibroblast", "growth", "factor", "bFGF", ")", "are", "C0086376#ent", "<e1>", "implicated", "in", "tumor-associated", "C0206064#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0206064", "name": "C0206064#ent", "pos": [19, 20]}}
{"token": ["At", "least", "one", "of", "these", "C0086376#ent", "<e1>", "accumulated", "in", "the", "C0206064#ent", "<e2>", "the", "telencephalon", "slices", "were", "incubated", "in", "vinblastine", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0206064", "name": "C0206064#ent", "pos": [10, 11]}}
{"token": ["The", "inhibitory", "effect", "of", "5-HT", "on", "C0812246#ent", "<e1>", "production", "was", "antagonized", "by", "C0022616#ent", "<e2>", ",", "a", "selective", "5-HT(2A", ")", "antagonist", ",", "and", "mimicked", "by", "DOI", ",", "a", "selective", "5-HT(2A/2C", ")", "agonist", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "TEA", "was", "increased", "only", "by", "C0036579#ent", "<e1>", ",", "while", "MET", ",", "NH(4)(+", ")", ",", "C2700301#ent", "<e2>", "and", "GLI", "were", "not", "affected", "by", "either", "of", "the", "inhibitors", "."], "h": {"id": "C0036579", "name": "C0036579#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2700301", "name": "C2700301#ent", "pos": [17, 18]}}
{"token": ["Under", "reverse", "isolation", "sterile", "units", "no", "severe", "bacterial", "or", "C0026946#ent", "<e1>", "seen", "in", "the", "phase", "of", "C1368107#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1368107", "name": "C1368107#ent", "pos": [16, 17]}}
{"token": ["Eight", "weeks", "after", "implantation", "of", "the", "DOCA", "pellets", ",", "C1420175#ent", "<e1>", "expression", "decreased", "by", "75", "%", "in", "aortas", "of", "C0020538#ent", "<e2>", "mice", ",", "but", "not", "in", "C1420175#ent", "<e1>", "TG", "hypertensive", "aortas", "."], "h": {"id": "C1420175", "name": "C1420175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [19, 20]}}
{"token": ["However", ",", "it", "was", "found", "that", "the", "levels", "of", "Al", "that", "accumulated", "in", "shoots", "of", "C1412368#ent", "<e1>", "are", "not", "different", "from", "the", "C1883559#ent", "<e2>"], "h": {"id": "C1412368", "name": "C1412368#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [22, 23]}}
{"token": ["Various", "aspects", "of", "C0013595#ent", "<e1>", "discussed", ",", "and", "a", "case", "of", "C0013595#ent", "<e1>", "secondary", "to", "atopic", "dermatitis", "complicated", "by", "C0376379#ent", "<e1>", "a", "young", "adult", "presented", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0376379", "name": "C0376379#ent", "pos": [19, 20]}}
{"token": ["Similar", "results", "were", "obtained", "after", "washing", "the", "dialysis", "membrane", "when", "C0064833#ent", "<e1>", "suspended", "in", "C1334043#ent", "<e2>"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}}
{"token": ["We", "have", "previously", "studied", "a", "collection", "of", "group", "G", "streptococcal", "strains", "isolated", "from", "bacteremic", "human", "infections", "and", "demonstrated", "that", "such", "strains", "resist", "phagocytosis", "by", "human", "C0064833#ent", "<e1>", "are", "type", "specifically", "opsonized", "by", "C1334043#ent", "<e2>"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [32, 33]}}
{"token": ["These", "studies", "suggest", "that", "C1367551#ent", "<e1>", "acts", "as", "a", "partial", "C0243192#ent", "<e2>", "to", "ADH", "within", "the", "distal", "nephron"], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}}
{"token": ["The", "Ni", "input", "can", "limit", "the", "maximum", "effect", "of", "PGE2", "and", "is", "capable", "of", "limiting", "C1367551#ent", "<e1>", "effects", "when", "the", "two", "C0243192#ent", "<e2>", "are", "used", "simultaneously", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [21, 22]}}
{"token": ["These", "observations", "demonstrate", "that", "C1367551#ent", "<e1>", "exerts", "specific", "and", "potent", "C0243192#ent", "<e2>", "actions", "in", "cardiac", "myocytes", "that", "regulation", "of", "myocardial", "responses", "C1367551#ent", "<e1>", "may", "occur", "by", "mechanisms", "involving", "increases", "in", "cAMP", "and", "receptor", "desensitization"], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}}
{"token": ["The", "activity", "of", "Ca-ATPase", "(", "Ca2+,Mg2+-ATPase", "C0003652#ent", "<e1>", "EC", "3.6.1.3", "was", "measured", "in", "erythrocyte", "membrane", "from", "37", "C0010674#ent", "<e2>", "patients", ",", "27", "with", "pancreatic", "insufficiency", "10", "with", "pancreatic", "sufficiency", "and", "from", "24", "healthy", "controls"], "h": {"id": "C0003652", "name": "C0003652#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [17, 18]}}
{"token": ["These", "C0002062#ent", "<e1>", "produce", "in", "0.5", "N", "NaOH", "C3536863#ent", "<e2>", "a", "sharp", "peak", "within", "the", "cathode", "region", "of", "the", "oscillogram", ",", "each", "of", "them", "showing", "different", "potential", "."], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [8, 9]}}
{"token": ["We", "found", "that", "one", "of", "these", "sites", "is", "bound", "in", "vivo", "HOXA13", "and", "C1415687#ent", "<e1>", "and", "by", "endogenous", "Hoxd13", "in", "developing", "mouse", "C0030196#ent", "<e2>", "."], "h": {"id": "C1415687", "name": "C1415687#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [22, 23]}}
{"token": ["Early", "in", "development", ",", "the", "pattern", "of", "C1415687#ent", "<e1>", "expression", "resembles", "that", "of", "Evx2", "in", "C0030196#ent", "<e2>", "and", "genital", "buds", "."], "h": {"id": "C1415687", "name": "C1415687#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [15, 16]}}
{"token": ["We", "show", "that", "C1415687#ent", "<e1>", "misexpression", "in", "developing", "C0030196#ent", "<e2>", "alters", "the", "expression", "of", "the", "majority", "of", "these", "genes", ",", "supporting", "the", "conclusion", "that", "C1415687#ent", "<e1>", "directly", "regulates", "their", "transcription", "."], "h": {"id": "C1415687", "name": "C1415687#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [8, 9]}}
{"token": ["Longitudinal", "data", "C1527310#ent", "<e1>", "are", "presented", "for", "a", "group", "of", "C0394007#ent", "<e2>", "patients", "who", "received", "no", "strabismus", "therapy", "."], "h": {"id": "C1527310", "name": "C1527310#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0394007", "name": "C0394007#ent", "pos": [10, 11]}}
{"token": ["The", "results", "of", "large", "outcome", "studies", "evaluated", "rofecoxib", "and", "C0538927#ent", "<e1>", "in", "over", "39,000", "patients", "with", "C0029408#ent", "<e2>", "or", "rheumatoid", "arthritis"], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [16, 17]}}
{"token": ["Some", "of", "these", "features", "could", "be", "consequent", "to", "differential", "epigenetic", "transcriptional", "deregulation", "at", "C1335654#ent", "<e1>", "targets", "imposed", "by", "C1851466#ent", "<e2>", "and", "AML1-MTG16", ",", "the", "fusion", "proteins", "from", "the", "two", "translocations", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [13, 14]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1851466", "name": "C1851466#ent", "pos": [18, 19]}}
{"token": ["Some", "of", "these", "features", "could", "be", "consequent", "to", "differential", "epigenetic", "transcriptional", "deregulation", "at", "C1335654#ent", "<e1>", "targets", "imposed", "by", "AML1-MTG8", "and", "C1851466#ent", "<e2>", ",", "the", "fusion", "proteins", "from", "the", "two", "translocations", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [13, 14]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1851466", "name": "C1851466#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "VE-cadherin", "and", "C1335280#ent", "<e1>", "differentially", "regulates", "VEGF", "C1332447#ent", "<e2>"], "h": {"id": "C1335280", "name": "C1335280#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [9, 10]}}
{"token": ["We", "hypothesized", "that", "flow", "induces", "assembly", "of", "the", "multi-protein", "complexes", "C1335280#ent", "<e1>", "that", "are", "required", "for", "C1332447#ent", "<e2>"], "h": {"id": "C1335280", "name": "C1335280#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [16, 17]}}
{"token": ["In", "Japanese", "C0074204#ent", "<e1>", "cases", ",", "a", "majority", "of", "the", "C0277565#ent", "<e2>", "sheep", "were", "from", "Suffolk", ",", "while", "8", "cases", "were", "from", "Corriedale", "."], "h": {"id": "C0074204", "name": "C0074204#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [10, 11]}}
{"token": ["After", "non-cardiac", "surgery", "myocardial", "infarction", "observed", "in", "5.6", "%", "of", "patients", "with", "C1956346#ent", "<e1>", "the", "rate", "in", "patients", "with", "C0018799#ent", "<e2>", "0.1", "-", "0.7", "%", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [19, 20]}}
{"token": ["With", "rotation", "to", "the", "C0277565#ent", "<e1>", "side", ",", "most", "subjects", "exhibited", "a", "horizontal", "bias", "component", "(", "C0063382#ent", "<e2>", ")", "to", "the", "opposite", "side", "as", "compared", "with", "the", "C0277565#ent", "<e1>", "side", "in", "normal", "subjects"], "h": {"id": "C0063382", "name": "C0063382#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [4, 5]}}
{"token": ["In", "addition", "to", "its", "effects", "at", "the", "renal", "tubules", "influence", "water", "retention", "at", "C1412137#ent", "<e1>", "cause", "vasoconstriction", ",", "the", "C1366535#ent", "<e2>", "appears", "to", "modulate", "cardiovascular", "reflex", "control", "of", "the", "sympathetic", "nervous", "system"], "h": {"id": "C1412137", "name": "C1412137#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [19, 20]}}
{"token": ["C0031463#ent", "<e1>", "is", "a", "highly", "useful", "anti-inflammatory", "agent", "especially", "in", "management", "of", "C0003868#ent", "<e2>", "ankylosing", "(", "rheumatoid", ")", "spondylitis", ";", "its", "metabolite", ",", "oxyphenylbutazone", ",", "does", "not", "exhibit", "clear-cut", "advantages", "."], "h": {"id": "C0031463", "name": "C0031463#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0003868", "name": "C0003868#ent", "pos": [12, 13]}}
{"token": ["C0033551#ent", "<e1>", "(", "COX", ")", "as", "well", "as", "C1335227#ent", "<e2>", "PLK", ")", "are", "involved", "in", "proliferation", "and", "cell", "cycle", "regulation", "have", "been", "suggested", "for", "preventive", "and", "therapeutic", "approaches", "prostate", "carcinoma"], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [8, 9]}}
{"token": ["The", "syndrome", "of", "C0030794#ent", "<e1>", "an", "obvious", "pathology", "has", "been", "described", "as", "C0152078#ent", "<e2>", "Taylor", ")", "syndrome", "."], "h": {"id": "C0030794", "name": "C0030794#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0152078", "name": "C0152078#ent", "pos": [12, 13]}}
{"token": ["The", "fact", "that", "addition", "of", "cadmium", "did", "not", "change", "the", "C4283936#ent", "<e1>", "type", "2", "C", "neurones", "shows", "that", "the", "IA", "is", "not", "C0249866#ent", "<e2>"], "h": {"id": "C4283936", "name": "C4283936#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0249866", "name": "C0249866#ent", "pos": [22, 23]}}
{"token": ["Arginase", ",", "which", "catalyzes", "the", "conversion", "of", "arginine", "to", "urea", "and", "ornithine", ",", "and", "consists", "of", "a", "C3500855#ent", "<e1>", "(", "arginase", "I", "and", "a", "non-hepatic", "type", "(", "C1412515#ent", "<e2>", "."], "h": {"id": "C3500855", "name": "C3500855#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412515", "name": "C1412515#ent", "pos": [27, 28]}}
{"token": ["These", "changes", "were", "irrespective", "of", "C3500855#ent", "<e1>", "plasma", "levels", "and", "were", "explained", "by", "C1412515#ent", "<e2>", "activity", "present", "in", "intact", "erythrocytes", "."], "h": {"id": "C3500855", "name": "C3500855#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412515", "name": "C1412515#ent", "pos": [13, 14]}}
{"token": ["Most", "C1335439#ent", "<e1>", "increased", "frameshift", "frequencies", "but", "a", "few", "C0002085#ent", "<e2>", "(", "previously", "noted", "as", "antimutators", "for", "base", "substitution", "mutations", "decreased", "the", "frequencies", "of", "certain", "frameshifts", "while", "increasing", "the", "frequencies", "of", "others", "."], "h": {"id": "C1335439", "name": "C1335439#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}}
{"token": ["The", "intervaricose", "segments", "C0029436#ent", "<e1>", ",", "and", "the", "C0042345#ent", "<e2>", "become", "disconnected", ",", "spherical", "in", "shape", "and", "either", "swollen", "or", "more", "electron-dense", "."], "h": {"id": "C0029436", "name": "C0029436#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [8, 9]}}
{"token": ["The", "C1706600#ent", "<e1>", "phosphorylation", "of", "C3273591#ent", "<e2>", "and", "mPer3", "proteins", "results", "in", "their", "rapid", "degradation", ",", "which", "is", "dependent", "on", "the", "ubiquitin-proteasome", "pathway"], "h": {"id": "C1706600", "name": "C1706600#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273591", "name": "C3273591#ent", "pos": [5, 6]}}
{"token": ["These", "results", "suggest", "that", "C0085228#ent", "<e1>", "specifically", "reduced", "activation", "of", "the", "ACC", "and", "C1420622#ent", "<e2>", ",", "which", "are", "areas", "concerned", "with", "the", "affective", "and", "integrative", "components", "of", "pain", "."], "h": {"id": "C0085228", "name": "C0085228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420622", "name": "C1420622#ent", "pos": [13, 14]}}
{"token": ["Stronger", "binding", "of", "C1334498#ent", "<e1>", "and", "PTN", "to", "the", "CS", "chains", "syndecan-4", "than", "those", "of", "C1419891#ent", "<e2>", "was", "revealed", ",", "supporting", "the", "structural", "and", "functional", "differences", "."], "h": {"id": "C1334498", "name": "C1334498#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419891", "name": "C1419891#ent", "pos": [15, 16]}}
{"token": ["Methyl", "palmoxirate", "rapidly", "converted", "to", "its", "acid", ",", "C0046565#ent", "<e1>", ",", "by", "horse", "serum", "C3541394#ent", "<e2>", "present", "in", "the", "treatment", "medium"], "h": {"id": "C0046565", "name": "C0046565#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [14, 15]}}
{"token": ["PBS/IC", "should", "be", "correctly", "diagnosed", "as", "early", "in", "the", "disease", "course", "possible", "in", "order", "to", "avoid", "C3714552#ent", "<e1>", "detriments", "to", "the", "patients", "'", "QOL", "in", "C3274826#ent", "<e2>"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3274826", "name": "C3274826#ent", "pos": [25, 26]}}
{"token": ["C0060179#ent", "<e1>", "a", "hypolipidemic", "drug", "inhibits", "3-hydroxy-3-methyl-glutaryl", "coenzyme", "A", "reductase", "C2975999#ent", "<e2>", "activity", ",", "the", "limiting", "step", "of", "endogenous", "cholesterol", "synthesis"], "h": {"id": "C0060179", "name": "C0060179#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2975999", "name": "C2975999#ent", "pos": [10, 11]}}
{"token": ["We", "recently", "found", "that", "C0035339#ent", "<e1>", ",", "which", "are", "vitamin", "A", "derivatives", ",", "exert", "C3536711#ent", "<e2>", "effects", "by", "upregulating", "thrombomodulin", "(", "TM", ")", "and", "downregulating", "tissue", "factor", "TF", ")", "expression", "in", "acute", "promyelocytic", "leukemia", "cells", "monoblastic", "leukemia", "cells"], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [14, 15]}}
{"token": ["V2O5-induced", "C1704816#ent", "<e1>", "mRNA", "expression", "was", "inhibited", "by", "the", "C1443775#ent", "<e2>", "AG1478", ",", "the", "p38", "mitogen-activated", "protein", "MAP", ")", "kinase", "inhibitor", "SB203580", ",", "and", "the", "MAP", "kinase", "kinase", "inhibitor", "PD98059", "."], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1443775", "name": "C1443775#ent", "pos": [9, 10]}}
{"token": ["The", "increased", "perception", "of", "the", "C0234230#ent", "<e1>", "for", ">", "1", "h", "after", "C0019104#ent", "<e2>", "is", "interpreted", "as", "a", "LTP-like", "facilitation", "of", "the", "conditioned", "cutaneous", "C-fiber", "pathway", "."], "h": {"id": "C0234230", "name": "C0234230#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", "to", "thrombin", ",", "ionomycin", "effected", "a", "dramatic", "decrease", "in", "the", "phosphotyrosine-to-immunoreactive", "C1565427#ent", "<e1>", "ratios", ",", "suggesting", "distinct", "effects", "of", "the", "two", "C0991617#ent", "<e2>", "on", "C1565427#ent", "<e1>", "phosphorylation", "and", "function", "."], "h": {"id": "C1565427", "name": "C1565427#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [23, 24]}}
{"token": ["The", "C0012863#ent", "<e1>", "from", "tumor", "and", "liver", "cells", "of", "two", "C0599220#ent", "<e2>", "with", "molecular", "masses", "about", "160", "kDa", "."], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [10, 11]}}
{"token": ["Escherichia", "coli", "topoisomerase", "IV", "a", "C0012863#ent", "<e1>", "of", "ParC", "and", "C0599220#ent", "<e2>", "plays", "a", "major", "role", "in", "the", "decatenation", "of", "replicated", "molecules", "."], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [10, 11]}}
{"token": ["C0017337#ent", "<e1>", "of", "the", "C1414315#ent", "<e2>", "EGR", ")", "family", "encode", "transcription", "factors", "a", "highly", "conserved", "DNA", "binding", "zinc", "finger", "domain", "which", "regulate", "a", "variety", "of", "genes", ",", "e.g.", "late", "myelin", "genes"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414315", "name": "C1414315#ent", "pos": [4, 5]}}
{"token": ["C0073992#ent", "<e1>", "inhaled", "before", "allergen", "challenge", "prevented", "the", "early", "asthmatic", "response", "C0004096#ent", "<e2>", "fall", "in", "methacholine", "PC20", "at", "24", "h", ",", "and", "produced", "additional", "bronchodilatation", "."], "h": {"id": "C0073992", "name": "C0073992#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}}
{"token": ["C1566598#ent", "<e1>", "EC", "1.14.16.4", ";", "L-tryptophan", "tetrahydropteridine", ":", "C0023837#ent", "<e2>", "was", "purified", "to", "electrophoretic", "homogeneity", "from", "whole", "brain", "supernatant", "the", "following", "steps", ":", "pteridine-argarose", "affinity", "chromatography", "hydrophobic", "and", "finally", "hydroxyapatite", "chromatography"], "h": {"id": "C1566598", "name": "C1566598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [8, 9]}}
{"token": ["Bradykinin", "and", "related", "C0030956#ent", "<e1>", "have", "been", "considered", "important", "as", "C0127400#ent", "<e2>", "of", "acute", "inflammation", "but", "their", "role", "in", "the", "cell-mediated", "immune", "response", "not", "been", "extensively", "investigated", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [10, 11]}}
{"token": ["Alloreactive", "T", "lymphocytes", "respond", "directly", "to", "foreign", "major", "histocompatibility", "complex", "MHC", ")", "molecules", "and", "C0030956#ent", "<e1>", "known", "to", "be", "C0127400#ent", "<e2>", "graft-versus-host", "disease", "GVHD", ")", "and", "allograft", "rejection"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [19, 20]}}
{"token": ["Isolation", "of", "SMA4", "by", "positional", "cloning", "that", "it", "encodes", "C1414518#ent", "<e1>", ",", "a", "member", "of", "the", "C3710848#ent", "<e2>"], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3710848", "name": "C3710848#ent", "pos": [16, 17]}}
{"token": ["One", "we", "named", "C1414518#ent", "<e1>", ",", "as", "it", "has", "high", "similarity", "to", "the", "C3710848#ent", "<e2>", "Saccharomyces", "cerevisiae"], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3710848", "name": "C3710848#ent", "pos": [13, 14]}}
{"token": ["We", "measured", "ovarian", "lipid", "peroxide", "C2239920#ent", "<e1>", ")", "levels", "and", "plasma", "progestins", ",", "progesterone", "(", "C1539372#ent", "<e2>", ")", "and", "20alpha-dihydroprogesterone", ",", "throughout", "pseudopregnancy", "in", "gonadotropin-primed", "immature", "rats", "."], "h": {"id": "C2239920", "name": "C2239920#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539372", "name": "C1539372#ent", "pos": [15, 16]}}
{"token": ["The", "diagnosis", "of", "C0679381#ent", "<e1>", "be", "a", "sign", "of", "C0012634#ent", "<e2>", "diseases", "."], "h": {"id": "C0679381", "name": "C0679381#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "report", "that", "the", "INHAT", "complex", "and", "its", "C0599220#ent", "<e1>", "have", "overlapping", "but", "distinct", "C1540026#ent", "<e2>", "inhibitory", "and", "histone", "binding", "characteristics", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1540026", "name": "C1540026#ent", "pos": [15, 16]}}
{"token": ["We", "also", "provide", "experimental", "evidence", "OFD1", ",", "together", "with", "RuvBl1", ",", "is", "able", "to", "coimmunoprecipitate", "with", "C0599220#ent", "<e1>", "of", "the", "human", "TIP60", "histone", "acetyltransferase", "C1540026#ent", "<e2>", ")", "multisubunit", "complex"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1540026", "name": "C1540026#ent", "pos": [24, 25]}}
{"token": ["Cyclic", "C4285220#ent", "<e1>", "analogues", "and", "[", "C1332433#ent", "<e2>", "also", "stimulated", "the", "protein", "secretion", "dose-dependent", "manner", "."], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332433", "name": "C1332433#ent", "pos": [6, 7]}}
{"token": ["When", "centrosomes", "were", "isolated", "from", "cells", "treated", "with", "C0028247#ent", "<e1>", ",", "an", "MT-disrupting", "agent", ",", "centlein", "and", "the", "C1824717#ent", "<e2>", "gamma-tubulin", ",", "were", "enriched", "in", "the", "same", "fractions", "."], "h": {"id": "C0028247", "name": "C0028247#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1824717", "name": "C1824717#ent", "pos": [18, 19]}}
{"token": ["C0057911#ent", "<e1>", "or", "SITS", "attenuated", "oxygen-glucose", "deprivation-induced", "increases", "in", "extracellular", "C0017789#ent", "<e2>", "concentrations", "and", "intracellular", "Ca(2+)"], "h": {"id": "C0057911", "name": "C0057911#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "high", "concentrations", "of", "chloride", "but", "not", "of", "C0017789#ent", "<e1>", "or", "other", "anions", "prevented", "C0057911#ent", "<e2>", "inhibition", "of", "C0017789#ent", "<e1>", "uptake", "."], "h": {"id": "C0057911", "name": "C0057911#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [9, 10]}}
{"token": ["Combined", "deletion", "in", "mice", "of", "two", "C0031727#ent", "<e1>", "Rlk", "and", "C1567665#ent", "<e2>", ",", "caused", "marked", "defects", "in", "TCR", "responses", "including", "proliferation", ",", "cytokine", "production", "and", "apoptosis", "in", "vitro", "adaptive", "immune", "responses", "Toxoplasma", "gondii", "in", "vivo"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1567665", "name": "C1567665#ent", "pos": [10, 11]}}
{"token": ["Hypoxia", "was", "also", "found", "to", "increase", "mRNA", "levels", "of", "the", "C1333196#ent", "<e1>", "CXCL-12", "and", "its", "receptor", "C1332823#ent", "<e2>", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [16, 17]}}
{"token": ["GM-CSF", ",", "a", "C1333196#ent", "<e1>", "that", "induces", "macrophage", "differentiation", "caused", "a", "rapid", "decrease", "in", "C1332823#ent", "<e2>", "and", "CCR5", "mRNA", "and", "was", "correlated", "with", "decreased", "ability", "to", "support", "HIV", "entry", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [14, 15]}}
{"token": ["However", ",", "when", "infused", "after", "C0004609#ent", "<e1>", ",", "C0000254#ent", "<e2>", "blocked", "the", "C0004609#ent", "<e1>", "induced", "increase", "in", "EPSP", "duration", "."], "h": {"id": "C0000254", "name": "C0000254#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004609", "name": "C0004609#ent", "pos": [5, 6]}}
{"token": ["C0059438#ent", "<e1>", "inhibited", "the", "activation", "of", "IFN", "regulatory", "factor", "3", "C1334139#ent", "<e2>", ")", "induced", "by", "LPS", ",", "poly[I", ":", "C", "]", ",", "or", "the", "overexpression", "of", "TRIF", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334139", "name": "C1334139#ent", "pos": [10, 11]}}
{"token": ["Outbreaks", "among", "more", "than", "15", "Israeli", "dairy", "sheep", "and", "goat", "C1519228#ent", "<e1>", "presented", "clinical", "signs", "including", "C0017086#ent", "<e2>"], "h": {"id": "C1519228", "name": "C1519228#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017086", "name": "C0017086#ent", "pos": [16, 17]}}
{"token": ["C3543418#ent", "<e1>", "1,25-(OH)(2)D(3", ")", ")", "has", "potent", "C0003392#ent", "<e2>", "in", "vitro", "various", "cell", "types", "however", ",", "its", "role", "in", "ASMCs", "is", "not", "well", "understood", "."], "h": {"id": "C3543418", "name": "C3543418#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [7, 8]}}
{"token": ["Superficial", "C0026946#ent", "<e1>", "tinea", "infections", "also", "known", "as", "the", "C0011636#ent", "<e2>", ")", "are", "commonly", "encountered", "conditions", "in", "clinical", "practice", "affecting", "the", "skin", ",", "hair", ",", "and", "nails", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0011636", "name": "C0011636#ent", "pos": [9, 10]}}
{"token": ["We", "have", "attempted", "to", "introduce", "a", "C1366752#ent", "<e1>", "recombined", "in", "a", "murine", "(", "ecotropic", ")", "Moloney", "retrovirus", "into", "C1422733#ent", "<e2>", "human", "cells", "are", "resistant", "to", "infection", "by", "this", "retrovirus", "."], "h": {"id": "C1366752", "name": "C1366752#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422733", "name": "C1422733#ent", "pos": [18, 19]}}
{"token": ["Revertants", "of", "C1413398#ent", "<e1>", "have", "been", "isolated", "which", "display", "decreased", "resistance", "to", "C0009262#ent", "<e2>", "and", "a", "corresponding", "decrease", "in", "resistance", "to", "other", "drugs", "."], "h": {"id": "C1413398", "name": "C1413398#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [12, 13]}}
{"token": ["C0526064#ent", "<e1>", "no", "local", "C0002932#ent", "<e2>", "no", "effect", "salivation", ",", "pupil", "size", "neuromuscular", "transmission", "the", "skeletal", "muscle"], "h": {"id": "C0526064", "name": "C0526064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002932", "name": "C0002932#ent", "pos": [4, 5]}}
{"token": ["C0001275#ent", "<e1>", "removes", "the", "bound", "nucleotide", "from", "the", "pea", "C0027203#ent", "<e2>", "not", "from", "the", "pea", "shoot", "enzymes", "."], "h": {"id": "C0001275", "name": "C0001275#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["We", "studied", "the", "effectiveness", "of", "C0055895#ent", "<e1>", "ointment", "0.05", "%", "in", "experimentally", "induced", "C0011603#ent", "<e2>"], "h": {"id": "C0055895", "name": "C0055895#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0011603", "name": "C0011603#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "C1413902#ent", "<e1>", "activation", "of", "PKC", "stimulates", "other", "signal", "transduction", "pathways", "support", "cell", "proliferation", "eg", "C0752312#ent", "<e2>", "MAPK", ",", "pathways", ")", "."], "h": {"id": "C1413902", "name": "C1413902#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [16, 17]}}
{"token": ["Diacylglycerol", "(", "C1413902#ent", "<e1>", ")", "and", "calcium", "produce", "the", "activation", "of", "PKC", ",", "C0752312#ent", "<e2>", "and", "JNK", "kinases", "implying", "a", "normal", "IL-2", "response", "."], "h": {"id": "C1413902", "name": "C1413902#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [13, 14]}}
{"token": ["However", ",", "clone", "myl", "6", "appears", "to", "be", "the", "human", "C1334043#ent", "<e1>", "of", "the", "3", "'", "end", "region", "of", "C1420705#ent", "<e2>", "metalloproteinase", "3", "TIMP-3", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420705", "name": "C1420705#ent", "pos": [19, 20]}}
{"token": ["During", "clinical", "course", "typical", "signs", "include", "sudden", "onset", "severe", "and", "poorly", "controlled", "hypertension", "C1565489#ent", "<e1>", "proteinuria", "and", "C0152132#ent", "<e2>"], "h": {"id": "C1565489", "name": "C1565489#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0152132", "name": "C0152132#ent", "pos": [17, 18]}}
{"token": ["Up-regulation", "of", "C1412417#ent", "<e1>", "could", "contribute", "to", "the", "reported", "anti-inflammatory", "effects", "butyrate", "in", "colon", "C1290884#ent", "<e2>"], "h": {"id": "C1412417", "name": "C1412417#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [14, 15]}}
{"token": ["Endothelial-Monocyte-Activating", "Polypeptide", "II", "(", "C1419881#ent", "<e1>", "is", "a", "proinflammatory", "C1333196#ent", "<e2>", "and", "chemoattractant", "of", "macrophages", "."], "h": {"id": "C1419881", "name": "C1419881#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "C1419881#ent", "<e1>", "itself", "should", "be", "a", "real", "C1333196#ent", "<e2>", "secreted", "by", "an", "active", "mechanism"], "h": {"id": "C1419881", "name": "C1419881#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [11, 12]}}
{"token": ["FoxO1", "binds", "to", "an", "insulin", "response", "element", "the", "rat", "C2976704#ent", "<e1>", "which", "is", "not", "present", "in", "the", "human", "C1413893#ent", "<e2>"], "h": {"id": "C2976704", "name": "C2976704#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413893", "name": "C1413893#ent", "pos": [18, 19]}}
{"token": ["The", "mRNA", "expression", "levels", "of", "C2976704#ent", "<e1>", "and", "several", "nuclear", "receptors", "to", "regulate", "the", "C1413893#ent", "<e2>", "assayed", "in", "human", "primary", "hepatocytes", "by", "quantitative", "real-time", "PCR", "Q-PCR", ")", "."], "h": {"id": "C2976704", "name": "C2976704#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413893", "name": "C1413893#ent", "pos": [14, 15]}}
{"token": ["The", "nm23", "gene", "initially", "cloned", "as", "a", "C0949706#ent", "<e1>", "but", "the", "clinical", "relevance", "nm23", "as", "a", "C0949486#ent", "<e2>", "prognostic", "indicator", "human", "cancers", "remain", "controversial", "."], "h": {"id": "C0949706", "name": "C0949706#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0949486", "name": "C0949486#ent", "pos": [16, 17]}}
{"token": ["Amino-terminal", "variants", "bGH", "included", "methionine", "(", "C1415383#ent", "<e1>", ")", ",", "alanine", "(", "Ala1", ")", ",", "serine", "(", "C3273591#ent", "<e2>", ")", "or", "deletion", "of", "four", "amino", "acids", "delta", "1", "-", "4", ")", "."], "h": {"id": "C1415383", "name": "C1415383#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273591", "name": "C3273591#ent", "pos": [17, 18]}}
{"token": ["A", "multiple", "alignment", "of", "the", "deduced", "cathepsin", "C", "sequence", "233", "residues", "which", ",", "by", "analogy", "to", "other", "C0010656#ent", "<e1>", "corresponds", "to", "the", "mature", "protein", "confirms", "that", "human", "C1413811#ent", "<e2>", "to", "the", "papain", "superfamily"], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413811", "name": "C1413811#ent", "pos": [27, 28]}}
{"token": ["The", "lipid", "which", "tended", "to", "be", "associated", "with", "C1419385#ent", "<e1>", "in", "protein-lipid-detergent", "mixed", "micelles", "was", "also", "consistently", "richer", "in", "C3810569#ent", "<e2>", "than", "that", "present", "in", "lipid-detergent", "micelles", "."], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", ",", "we", "cloned", "and", "sequenced", "the", "C1334043#ent", "<e1>", "of", "ETV6", "from", "the", "compact", "genome", "of", "the", "pufferfish", "Fugu", "rubripes", "C1705696#ent", "<e2>", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705696", "name": "C1705696#ent", "pos": [22, 23]}}
{"token": ["Our", "results", "demonstrate", "for", "the", "first", "time", "that", "C1704743#ent", "<e1>", "is", "specifically", "up-regulated", "by", "a", "C3536710#ent", "<e2>", ",", "a", "steroid", "known", "to", "induce", "the", "differentiation", "of", "epithelial", "mammary", "cells"], "h": {"id": "C1704743", "name": "C1704743#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536710", "name": "C3536710#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", "32", "corneal", "tissues", "16", "donors", "positive", "HBsAg", "were", "examined", "for", ",", "the", "presence", "of", "C0019163#ent", "<e1>", "by", "in", "situ", "DNA", "hybridization", "technique", "detect", "C0019163#ent", "<e1>", "DNA", "in", "the", "C0729777#ent", "<e1>"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0729777", "name": "C0729777#ent", "pos": [31, 32]}}
{"token": ["Here", ",", "we", "show", "that", "the", "domain", "is", "stable", "and", "can", "be", "phosphorylated", "by", "C0034348#ent", "<e1>", "and", "the", "C0031727#ent", "<e2>"], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}}
{"token": ["To", "examine", "this", "possibility", ",", "various", "C0034348#ent", "<e1>", "pyk", ")", "and", "C0031727#ent", "<e2>", "pts", ")", "mutants", "were", "tested", "for", "acetate", "production", "batch", "cultures", "glucose", "as", "the", "only", "carbon", "source", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["Enzyme", "I", "the", "phosphoenolpyruvate", ":", "protein", "phosphotransferase", "EC", "2.7.3.9", ")", ",", "which", "is", "part", "of", "the", "C0034348#ent", "<e1>", "PEP", ")", "dependent", "C0031727#ent", "<e2>", "has", "been", "purified", "from", "Streptococcus", "faecalis", "using", "a", "large-scale", "preparation", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [16, 17]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["Our", "biochemical", "characterization", "demonstrated", "that", "ACAP4", "has", "a", "phosphatidylinositol", "4,5-bisphosphate-dependent", "C1419277#ent", "<e1>", "activity", "specific", "for", "C1412511#ent", "<e2>", "."], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412511", "name": "C1412511#ent", "pos": [15, 16]}}
{"token": ["The", "main", "determinants", "of", "health", "burden", "are", "acute", "gastroenteritis", "440", "C0206461#ent", "<e1>", ")", ",", "C0152517#ent", "<e2>", "related", "mortality", "(", "310", "C0206461#ent", "<e1>", ")", "and", "residual", "symptoms", "of", "Guillain-Barr\u00e9", "syndrome", "340", "C0206461#ent", "<e1>", ")", "."], "h": {"id": "C0152517", "name": "C0152517#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0206461", "name": "C0206461#ent", "pos": [10, 11]}}
{"token": ["Poly(ADP-ribose)", "polymerase", "1", "C1428200#ent", "<e1>", ")", "is", "a", "nuclear", "zinc", "finger", "C1413746#ent", "<e2>", "is", "implicated", "in", "the", "repair", "of", "DNA", "damage"], "h": {"id": "C1428200", "name": "C1428200#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413746", "name": "C1413746#ent", "pos": [11, 12]}}
{"token": ["We", "now", "show", "that", "these", "autoantibodies", "are", "directed", "against", "BARD1", ",", "originally", "identified", "as", "a", "C3539609#ent", "<e1>", "the", "product", "of", "the", "breast", "cancer", "gene", "1", "C0376571#ent", "<e2>", "."], "h": {"id": "C3539609", "name": "C3539609#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0376571", "name": "C0376571#ent", "pos": [25, 26]}}
{"token": ["C3897009#ent", "<e1>", "tested", "by", "direct", "fluorescent", "assay", "influenza", ",", "parainfluenza", ",", "C0001486#ent", "<e2>", ",", "and", "respiratory", "syncytial", "virus"], "h": {"id": "C3897009", "name": "C3897009#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [11, 12]}}
{"token": ["Using", "specific", "antibodies", "the", "electrophoretic", "coordinates", "of", "rab4", ",", "rap1a/b", ",", "and", "C1705621#ent", "<e1>", "were", "identified", "for", "native", "as", "well", "as", "for", "crosslinked", "C0018296#ent", "<e2>", "."], "h": {"id": "C1705621", "name": "C1705621#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [23, 24]}}
{"token": ["C1705621#ent", "<e1>", "is", "a", "member", "of", "the", "Ras", "family", "C0018296#ent", "<e2>", "and", "exhibits", "60", "%", "identity", "to", "Rap1", ",", "but", "the", "function", "and", "regulation", "of", "C1705621#ent", "<e1>", "remain", "obscure", "."], "h": {"id": "C1705621", "name": "C1705621#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [9, 10]}}
{"token": ["We", "expressed", "the", "two", "C1704843#ent", "<e1>", "variants", "in", "vivo", "using", "the", "3", "'", "regulatory", "element", "C0796355#ent", "<e2>", "that", "is", "selectively", "active", "in", "a", "subset", "of", "mesodermal", "cell", "lineages", "including", "endothelial", "and", "hematopoietic", "stem", "cells", "progenitors", "."], "h": {"id": "C1704843", "name": "C1704843#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0796355", "name": "C0796355#ent", "pos": [15, 16]}}
{"token": ["An", "in-gel", "kinase", "assay", "demonstrated", "that", "C3811163#ent", "<e1>", "is", "a", "major", "C0380241#ent", "<e2>", "can", "phosphorylate", "small", "heat", "shock", "protein", "suggesting", "a", "potential", "role", "for", "C3811163#ent", "<e1>", "in", "mediating", "stress-induced", "HSP27", "phosphorylation", "in", "vivo"], "h": {"id": "C0380241", "name": "C0380241#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3811163", "name": "C3811163#ent", "pos": [6, 7]}}
{"token": ["IgA", "nephropathy", "IgAN", ")", "characterized", "by", "C0221238#ent", "<e1>", "predominant", "mesangial", "IgA", "deposition", "is", "the", "commonest", "C0156221#ent", "<e2>", "worldwide", "."], "h": {"id": "C0221238", "name": "C0221238#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [15, 16]}}
{"token": ["Finally", ",", "the", "similar", "PRL", "and", "C0162309#ent", "<e1>", "response", "in", "normotensives", "and", "C0003364#ent", "<e2>", "does", "not", "support", "the", "hypothesis", "of", "a", "reduced", "dopaminergic", "system", "activity", "in", "essential", "hypertensives"], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [12, 13]}}
{"token": ["An", "infant", "who", "developed", "pancreatitis", "during", "C0025179#ent", "<e1>", "treatment", "for", "C0023290#ent", "<e2>", "who", "was", "successfully", "treated", "with", "combination", "of", "allopurinol", "and", "ketoconazole", "is", "reported", "."], "h": {"id": "C0025179", "name": "C0025179#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [10, 11]}}
{"token": ["Primary", "and", "secondary", "unresponsiveness", "C0025179#ent", "<e1>", "has", "long", "been", "described", "in", "human", "C0023290#ent", "<e2>"], "h": {"id": "C0025179", "name": "C0025179#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [12, 13]}}
{"token": ["C0025179#ent", "<e1>", "Glucantime", ")", "is", "used", "to", "treat", "C0023290#ent", "<e2>", "may", "give", "rise", "to", "serious", "and", "sometimes", "lethal", "complications", ":", "cardiac", ",", "hepatic", ",", "renal", "and", "haematological", "disease"], "h": {"id": "C0025179", "name": "C0025179#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [8, 9]}}
{"token": ["Psychiatric", "disorders", "behaviour", "problems", "found", "to", "be", "commoner", "in", "children", "and", "adolescents", "with", "inflammatory", "bowel", "disease", "C0021390#ent", "<e1>", ")", "than", "in", "matched", "comparison", "groups", "with", "C0723643#ent", "<e2>", "diabetes", "as", "well", "as", "in", "healthy", "children"], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0723643", "name": "C0723643#ent", "pos": [25, 26]}}
{"token": ["Psychiatric", "disorders", "behaviour", "problems", "found", "to", "be", "commoner", "in", "children", "and", "adolescents", "with", "C0021390#ent", "<e1>", "IBD", ")", "than", "in", "matched", "comparison", "groups", "with", "C0723643#ent", "<e2>", "diabetes", "as", "well", "as", "in", "healthy", "children"], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0723643", "name": "C0723643#ent", "pos": [23, 24]}}
{"token": ["In", "the", "liver", ",", "only", "C0526217#ent", "<e1>", "significantly", "decreased", "the", "activity", "of", "microsomal", "acyl-CoA", ":", "C0023194#ent", "<e2>"], "h": {"id": "C0526217", "name": "C0526217#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023194", "name": "C0023194#ent", "pos": [15, 16]}}
{"token": ["Most", "of", "the", "compounds", "demonstrated", "potent", "C1413259#ent", "<e1>", "inhibitory", "activity", ",", "and", "several", "exhibited", "higher", "selectivity", "for", "C1413259#ent", "<e1>", "than", "for", "C1709439#ent", "<e1>", "."], "h": {"id": "C1413259", "name": "C1413259#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1709439", "name": "C1709439#ent", "pos": [21, 22]}}
{"token": ["An", "initial", "diagnosis", "of", "possible", "C0014060#ent", "<e1>", "was", "made", "considering", "the", "presence", "of", "fever", ",", "C0151315#ent", "<e2>", "and", "abnormal", "CSF", "findings", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151315", "name": "C0151315#ent", "pos": [15, 16]}}
{"token": ["The", "antigen", "proteins", "the", "mAbs", "were", "identified", "by", "immunoblotting", "as", "core", "histones", "by", "immunoprecipitation", "followed", "by", "a", "peptide", "mass", "fingerprinting", "method", "C1334911#ent", "<e1>", "heterogeneous", "nuclear", "ribonucleoprotein", "A2/B1", "ribosomal", "protein", "S4", "linker", "histone", "and", "C1384510#ent", "<e2>", "."], "h": {"id": "C1334911", "name": "C1334911#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1384510", "name": "C1384510#ent", "pos": [33, 34]}}
{"token": ["We", "used", "a", "mouse", "model", "C0035243#ent", "<e1>", "investigate", "the", "role", "of", "Toll-like", "receptor", "2", "C1336634#ent", "<e2>", ")", "and", "TLR4", "in", "the", "host", "response", "Haemophilus", "influenzae"], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336634", "name": "C1336634#ent", "pos": [14, 15]}}
{"token": ["The", "cleavage", "of", "DNA", "binding", "protein", "both", "C0030940#ent", "<e1>", "was", "inhibited", ",", "in", "the", "presence", "of", "C2983550#ent", "<e2>", "lambda", "DNA"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2983550", "name": "C2983550#ent", "pos": [16, 17]}}
{"token": ["They", "found", "that", "the", "most", "frequent", "complication", "and", "most", "frequent", "cause", "of", "death", "was", "C0036690#ent", "<e1>", "from", "mediastinitis", "and", "C0014013#ent", "<e2>", "of", "the", "chest", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014013", "name": "C0014013#ent", "pos": [19, 20]}}
{"token": ["Rabbits", "were", "untreated", "or", "pretreated", "with", "0.5", "mg/kg", "of", "captopril", ",", "0.05", "mg/kg", "of", "C0072970#ent", "<e1>", "or", "20", "nmol/kg", "of", "Hoe", "140", "before", "30", "min", "C0151814#ent", "<e2>", "72", "h", "reperfusion", "."], "h": {"id": "C0072970", "name": "C0072970#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0151814", "name": "C0151814#ent", "pos": [25, 26]}}
{"token": ["Autosomal", "recessive", "inheritance", "due", "to", "pathogenic", "C1704812#ent", "<e1>", "mutations", "accounts", "for", "at", "least", "13", "%", "of", "C1567741#ent", "<e2>", "cases", "in", "this", "sample", "."], "h": {"id": "C1704812", "name": "C1704812#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C1567741", "name": "C1567741#ent", "pos": [16, 17]}}
{"token": ["C0961618#ent", "<e1>", "activated", "the", "C0248813#ent", "<e2>", "JNK", ")", "signal", "transduction", "pathway"], "h": {"id": "C0961618", "name": "C0961618#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [4, 5]}}
{"token": ["None", "of", "the", "parameters", "measured", "was", "significantly", "different", "between", "VP", "patients", "who", "had", "an", "insidious", "onset", "of", "parkinsonism", "(", "C0042454#ent", "<e1>", ")", "and", "those", "who", "had", "an", "acute", "onset", "C0042291#ent", "<e2>", ")", "."], "h": {"id": "C0042454", "name": "C0042454#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [29, 30]}}
{"token": ["The", "protective", "effect", "intracerebroventricular", "C3889379#ent", "<e1>", "was", "blocked", "by", "atropine", ",", "subdiaphragmatic", "vagotomy", "and", "C0054040#ent", "<e2>", "."], "h": {"id": "C3889379", "name": "C3889379#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054040", "name": "C0054040#ent", "pos": [14, 15]}}
{"token": ["These", "data", ",", "together", "with", "previous", "studies", ",", "indicate", "that", "C1413156#ent", "<e1>", "is", "a", "C1415740#ent", "<e2>", "its", "actin", "filament", "capping", "activity", "thin", "filament", "elongation", ",", "whereas", "its", "interaction", "with", "tropomyosin", "prevents", "thin", "filament", "depolymerization", "."], "h": {"id": "C1413156", "name": "C1413156#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [14, 15]}}
{"token": ["The", "physical", "C1823796#ent", "<e1>", "score", "correlated", "positively", "with", "final", "physical", "recovery", "C0342784#ent", "<e2>", "=", "0.79", ")", "."], "h": {"id": "C1823796", "name": "C1823796#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0342784", "name": "C0342784#ent", "pos": [11, 12]}}
{"token": ["We", "found", "that", "steroid", "induction", "of", "C0812235#ent", "<e1>", "was", "DHT-specific", "and", "that", "newly", "synthesized", "C0073186#ent", "<e2>", "post-translationally", "modified", "localized", "to", "endocytic", "vesicles"], "h": {"id": "C0812235", "name": "C0812235#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0073186", "name": "C0073186#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "examine", "the", "prevalence", "of", "exercise", "limitation", "due", "to", "C1135196#ent", "<e1>", "patients", "felt", "to", "have", "C0013404#ent", "<e2>", "their", "general", "medical", "practitioner", "not", "referred", "to", "hospital", "."], "h": {"id": "C1135196", "name": "C1135196#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [21, 22]}}
{"token": ["C1135196#ent", "<e1>", "DHF", ")", "is", "characterized", "by", "C0013404#ent", "<e2>", "due", "to", "increased", "left", "ventricular", "(", "LV", ")", "filling", "pressures", "stress", "."], "h": {"id": "C1135196", "name": "C1135196#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [7, 8]}}
{"token": ["Glutamate", "or", "deoxyuridine", "in", "the", "presence", "of", "Cu2+", "C0876231#ent", "<e1>", "ALA", ")", "reaction", "resulted", "in", "the", "formation", "of", "C0039925#ent", "<e2>", "reactive", "compounds", "TBAR", ")", ",", "which", "was", "linear", "up", "to", "2", "hr", "."], "h": {"id": "C0876231", "name": "C0876231#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [18, 19]}}
{"token": ["The", "cough", "threshold", "to", "citric", "acid", "capsaicin", "in", "patients", "with", "C1412502#ent", "<e1>", "and", "in", "normal", "volunteers", "measured", ",", "as", "well", "as", "C1334103#ent", "<e2>", "methacholine", "."], "h": {"id": "C1412502", "name": "C1412502#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334103", "name": "C1334103#ent", "pos": [21, 22]}}
{"token": ["We", "show", "that", "the", "Ras-activated", "PI3", "K", "pathway", "is", "required", "to", "induce", "rapid", "tumor", "growth", "enhanced", "proliferation", "of", "EpH4", "cells", "in", "C0009325#ent", "<e1>", "but", "fails", "to", "cause", "C1420138#ent", "<e2>", "in", "vitro", "in", "vivo"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420138", "name": "C1420138#ent", "pos": [27, 28]}}
{"token": ["We", "recruited", "8", "C1851945#ent", "<e1>", "carriers", "with", "dystonia", ",", "6", "C1851945#ent", "<e1>", "carriers", "without", "dystonia", ",", "6", "patients", "with", "C3888090#ent", "<e1>", "torticollis", ")", ",", "and", "10", "healthy", "control", "."], "h": {"id": "C1851945", "name": "C1851945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3888090", "name": "C3888090#ent", "pos": [19, 20]}}
{"token": ["Trauma", ",", "corneal", "scars", "various", "causes", ",", "phthisis", ",", "and", "C0339206#ent", "<e1>", "are", "important", "causes", "of", "C0750958#ent", "<e2>"], "h": {"id": "C0339206", "name": "C0339206#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0750958", "name": "C0750958#ent", "pos": [16, 17]}}
{"token": ["As", "with", "bladder", "response", ",", "C1537381#ent", "<e1>", "inhibited", "both", "the", "rate", "and", "amplitude", "of", "C0567085#ent", "<e2>", "contractions", "in", "all", "groups", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C1537381", "name": "C1537381#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [14, 15]}}
{"token": ["The", "standard", "protocol", "in", "vitro", "assessment", "of", "C0543495#ent", "<e1>", "MDIs", "involves", "C0085593#ent", "<e2>", "the", "MDI", "vigorously", "for", "30", "seconds", "and", "wasting", "the", "first", "two", "actuations", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085593", "name": "C0085593#ent", "pos": [11, 12]}}
{"token": ["The", "C3812755#ent", "<e1>", "mutant", "strain", "was", "also", "avirulent", "in", "an", "animal", "model", "C0085436#ent", "<e2>"], "h": {"id": "C3812755", "name": "C3812755#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085436", "name": "C0085436#ent", "pos": [12, 13]}}
{"token": ["In", "this", "report", ",", "rabbit", "antiidiotype", "(", "C1826755#ent", "<e1>", ")", "was", "produced", "to", "a", "human", "C1417831#ent", "<e2>", "antibody", "(", "Ab1", ")", "."], "h": {"id": "C1826755", "name": "C1826755#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417831", "name": "C1417831#ent", "pos": [15, 16]}}
{"token": ["ACTH", "values", "in", "the", "absence", "of", "C0014996#ent", "<e1>", "were", "not", "affected", "by", "saralasin", ",", "enalaprilat", ",", "and", "C0006938#ent", "<e2>", "and", "were", "increased", "by", "L", "363714"], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [17, 18]}}
{"token": ["Since", "NGF", "activates", "the", "tyrosine", "kinase", "activity", "gp140trk", ",", "the", "protein", "product", "the", "C0033713#ent", "<e1>", "we", "also", "examined", "the", "association", "of", "C2936824#ent", "<e2>", "gp140trk", "."], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [21, 22]}}
{"token": ["This", "reduction", "in", "activity", "was", "dose-dependently", "reversed", "by", "ibuprofen", ",", "rofecoxib", ",", "celecoxib", ",", "C0031990#ent", "<e1>", ",", "and", "dexamethasone", ",", "whereas", "C0060926#ent", "<e2>", "and", "amitriptyline", "were", "inactive", "."], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [21, 22]}}
{"token": ["All", "manifested", "diffuse", ",", "C1691228#ent", "<e1>", "and", "74", "%", "had", "demonstrable", "C0023895#ent", "<e2>"], "h": {"id": "C1691228", "name": "C1691228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [11, 12]}}
{"token": ["Therapeutic", "efforts", "have", "been", "aimed", "at", "increasing", "the", "level", "of", "C0297062#ent", "<e1>", "the", "membrane", "using", "C0035064#ent", "<e2>", "such", "as", "sodium", "butyrate"], "h": {"id": "C0297062", "name": "C0297062#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [15, 16]}}
{"token": ["This", "defined", "sequence", "of", "C0162628#ent", "<e1>", "severe", "CNS", "inflammation", "that", "was", "histomorphologically", "reminiscent", "of", "C0393484#ent", "<e2>", "a", "fatal", "human", "autoimmune", "disease"], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0393484", "name": "C0393484#ent", "pos": [14, 15]}}
{"token": ["Further", "RT-PCR", "analysis", "sequencing", "of", "the", "amplified", "products", "revealed", "a", "novel", "C3639981#ent", "<e1>", "fusion", "transcript", "in", "which", "nucleotide", "1216", "exon", "10", "of", "C1423601#ent", "<e2>", "was", "fused", "in-frame", "with", "nucleotide", "422", "exon", "6", "of", "SSX1", "."], "h": {"id": "C3639981", "name": "C3639981#ent", "pos": [11, 12]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1423601", "name": "C1423601#ent", "pos": [22, 23]}}
{"token": ["Since", "C1420262#ent", "<e1>", "is", "a", "small", "peptide", "we", "tested", "the", "ability", "of", "two", "penetrant", "enhancers", "--", "C0012403#ent", "<e2>", "and", "N-decylmethylsulfoxide", "(C10MS)--to", "promote", "transcutaneous", "passage", "of", "C1420262#ent", "<e1>", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420262", "name": "C1420262#ent", "pos": [1, 2]}}
{"token": ["When", "the", "localization", "of", "C0087052#ent", "<e1>", "was", "compared", "with", "that", "of", "C1416669#ent", "<e2>", ",", "both", "enzymes", "were", "found", "within", "the", "same", "granular", "tubular", "cells"], "h": {"id": "C0087052", "name": "C0087052#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416669", "name": "C1416669#ent", "pos": [11, 12]}}
{"token": ["The", "anti-kallikrein", "antibody", "also", "reacted", "with", "C0087052#ent", "<e1>", ",", "showing", "partial", "cross-reactivity", "between", "C1416669#ent", "<e2>", "and", "C0087052#ent", "<e1>", "when", "tested", "by", "double", "immunodiffusion", "by", "immunoelectrophoresis", "."], "h": {"id": "C0087052", "name": "C0087052#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416669", "name": "C1416669#ent", "pos": [13, 14]}}
{"token": ["We", "have", "isolated", "a", "2.1-kb", "cDNA", "clone", "from", "a", "human", "placental", "library", "encoding", "part", "of", "the", "C2347825#ent", "<e1>", "a", "major", "C0017366#ent", "<e2>", "basement", "membranes"], "h": {"id": "C2347825", "name": "C2347825#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0017366", "name": "C0017366#ent", "pos": [20, 21]}}
{"token": ["The", "lack", "of", "egress", "from", "C1420113#ent", "<e1>", "granular", "fractions", "was", "found", "for", "both", "endogenous", "and", "N-acetylmannosamine-derived", "C3833037#ent", "<e2>", "."], "h": {"id": "C1420113", "name": "C1420113#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3833037", "name": "C3833037#ent", "pos": [16, 17]}}
{"token": ["Fibroblasts", "from", "C1420113#ent", "<e1>", "parents", "did", "not", "accumulate", "excess", "free", "C3833037#ent", "<e2>", "and", "did", "not", "display", "a", "velocity", "of", "C3833037#ent", "<e2>", "egress", "significantly", "different", "from", "normal", "."], "h": {"id": "C1420113", "name": "C1420113#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3833037", "name": "C3833037#ent", "pos": [10, 11]}}
{"token": ["C0289932#ent", "<e1>", "(", "10(-8)M", ")", "also", "increased", "the", "C0242287#ent", "<e2>", "content", "and", "quantal", "size", "nerve-evoked", "fEPSPs", "and", "increased", "the", "response", "to", "exogenously", "applied", "acetylcholine", "(", "ACh", ")", "."], "h": {"id": "C0289932", "name": "C0289932#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242287", "name": "C0242287#ent", "pos": [8, 9]}}
{"token": ["Previously", ",", "C0919528#ent", "<e1>", "translocations", "involving", "the", "CREP-binding", "protein", "(", "C1705776#ent", "<e2>", ")", "gene", "at", "chromosome", "band", "16p13.3", "primarily", "been", "reported", "in", "treatment-related", "acute", "myeloid", "leukemia", "after", "chemotherapy", "for", "other", "primary", "malignancies", "topoisomerase", "II", "inhibitors"], "h": {"id": "C0919528", "name": "C0919528#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705776", "name": "C1705776#ent", "pos": [10, 11]}}
{"token": ["In", "this", "report", ",", "we", "show", "that", "purified", "human", "C1313497#ent", "<e1>", "induce", "human", "lung", "fibroblasts", "produce", "C1334122#ent", "<e2>", "and", "IL8", "."], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334122", "name": "C1334122#ent", "pos": [16, 17]}}
{"token": ["C0015967#ent", "<e1>", "present", "only", "on", "C3889128#ent", "<e2>", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [5, 6]}}
{"token": ["Thus", ",", "C1418766#ent", "<e1>", "may", "act", "to", "alter", "growth", "properties", "of", "breast", "cancer", "C1705347#ent", "<e2>", "enhancing", "CD1", "expression", "in", "these", "cells", "."], "h": {"id": "C1418766", "name": "C1418766#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705347", "name": "C1705347#ent", "pos": [13, 14]}}
{"token": ["However", ",", "C1366565#ent", "<e1>", "did", "not", "exert", "anti-HIV", "activity", "any", "experimental", "conditions", "and", "mechanistic", "studies", "C1366565#ent", "<e1>", "to", "have", "no", "inhibitory", "activity", "on", "HIV-1", "binding", "C1955880#ent", "<e1>", "protease", "."], "h": {"id": "C1366565", "name": "C1366565#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [25, 26]}}
{"token": ["Human", "C1418550#ent", "<e1>", "mutants", "with", "19", "different", "C2917660#ent", "<e2>", "substitutions", "at", "each", "P1", ",", "P2", ",", "or", "P3", "residue", "created", "and", "purified", "to", "compare", "their", "kallikrein", "binding", "activity"], "h": {"id": "C1418550", "name": "C1418550#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [7, 8]}}
{"token": ["However", ",", "the", "time-course", "of", "substitution", "differed", "between", "C0072892#ent", "<e1>", ",", "which", "substituted", "for", "cocaine", "10", "after", "administration", ",", "and", "C1880232#ent", "<e2>", "and", "R-(+)-7-OH-DPAT", ",", "which", "required", "60-min", "pretreatments", "."], "h": {"id": "C0072892", "name": "C0072892#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1880232", "name": "C1880232#ent", "pos": [20, 21]}}
{"token": ["This", "study", "is", "aimed", "both", "at", "characterizing", "an", "ATPase", "activity", "rat", "kidney", "equivalent", "to", "the", "C0018440#ent", "<e1>", "in", "bovine", "kidney", "medulla", "at", "localizing", "this", "C0014442#ent", "<e2>", "along", "the", "nephron", "."], "h": {"id": "C0018440", "name": "C0018440#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [24, 25]}}
{"token": ["C0018440#ent", "<e1>", "ubiquinone", "oxidoreductase", "complex", "I", "is", "the", "most", "complicated", "and", "least", "understood", "C0014442#ent", "<e2>", "of", "the", "respiratory", "chain"], "h": {"id": "C0018440", "name": "C0018440#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["N", ",", "N", "'", ",", "dicyclohexylcarbodiimide", "a", "well-established", "inhibitor", "of", "H+-translocating", "ATPases", "inhibits", "the", "C0018440#ent", "<e1>", "labels", "specifically", "subunit", "III", "of", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C0018440", "name": "C0018440#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [22, 23]}}
{"token": ["C1879974#ent", "<e1>", "also", "displayed", "toxicity", "to", "the", "C1842796#ent", "<e2>", "neurons", "but", "at", "a", "level", "compatible", "with", "inflammatory", "states", "50", "microgram/ml", ")", "."], "h": {"id": "C1879974", "name": "C1879974#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1842796", "name": "C1842796#ent", "pos": [7, 8]}}
{"token": ["One", "of", "18", "C0149521#ent", "<e1>", "patients", "and", "1", "of", "15", "healthy", "controls", "autoantibodies", "to", "calreticulin", "C0597298#ent", "<e2>", "none", "demonstrated", "autoantibodies", "to", "isoform", "2"], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [15, 16]}}
{"token": ["Changes", "in", "S'-specificity", "of", "C1413806#ent", "<e1>", "in", "frozen", "aqueous", "systems", "were", "suppressed", "by", "C0032483#ent", "<e2>", "at", "concentrations", "below", "1", "%", "(", "w/v", ")", "."], "h": {"id": "C1413806", "name": "C1413806#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [13, 14]}}
{"token": ["We", "report", "the", "case", "of", "a", "56", "year", "old", "male", "with", "C0392514#ent", "<e1>", "by", "hepatic", "cirrhosis", "insulin", "treated", "diabetes", "mellitus", "C0020619#ent", "<e2>", "and", "secondary", "hypothyroidism", "the", "latter", "which", "was", "corrected", "by", "iron", "depletion", "."], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020619", "name": "C0020619#ent", "pos": [20, 21]}}
{"token": ["C0035309#ent", "<e1>", ",", "particularly", ",", "age-related", "macular", "degeneration", "AMD", ")", "are", "difficult", "C0015397#ent", "<e2>", "treat", "."], "h": {"id": "C0035309", "name": "C0035309#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [12, 13]}}
{"token": ["Rapid", "infusion", "of", "vancomycin", "causes", "histamine-mediated", "side", "effects", ",", "hypotension", ",", "and", "C0521471#ent", "<e1>", ",", "known", "as", "\"", "C0039082#ent", "<e2>"], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}}
{"token": ["C0171406#ent", "<e1>", "energy", "production", "measured", "in", "60", "C0014964#ent", "<e2>", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014964", "name": "C0014964#ent", "pos": [7, 8]}}
{"token": ["In", "the", "most", "distal", "intestine", "oil", "feeding", "increased", "the", "activity", "of", "C0024361#ent", "<e1>", "choline", "phosphotransferase", "as", "compared", "to", "casein", "fed", "hamsters", ";", "C0163260#ent", "<e2>", "increased", "one-", "and", "one-half-fold", "."], "h": {"id": "C0024361", "name": "C0024361#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0163260", "name": "C0163260#ent", "pos": [22, 23]}}
{"token": ["On", "the", "other", "hand", ",", "C2987048#ent", "<e1>", "15", "-", "4513", "significantly", "increased", "beta-EN", "levels", "in", "the", "C0001614#ent", "<e2>", "and", "hypothalamus", "."], "h": {"id": "C2987048", "name": "C2987048#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [16, 17]}}
{"token": ["C0000544#ent", "<e1>", "also", "attenuated", "the", "hypotension", "and", "bradycardia", "to", "C0140591#ent", "<e2>", "and", "clonidine", "but", "was", "slower", "in", "onset", ",", "needing", "the", "full", "8", "weeks", "to", "reach", "its", "maximum", "effect", "."], "h": {"id": "C0000544", "name": "C0000544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0140591", "name": "C0140591#ent", "pos": [9, 10]}}
{"token": ["Liver", "dysfunction", "C0042075#ent", "<e1>", "observed", "during", "C0595993#ent", "<e2>"], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0595993", "name": "C0595993#ent", "pos": [6, 7]}}
{"token": ["In", "the", "genistein-pretreated", "platelets", ",", "pp60(c-)src", ",", "Gq", ",", "and", "C1565919#ent", "<e1>", "no", "longer", "able", "to", "associate", "with", "C1307053#ent", "<e2>", "."], "h": {"id": "C1565919", "name": "C1565919#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [18, 19]}}
{"token": ["The", "in", "vivo", "consequences", "of", "exposure", "to", "polychlorinated", "biphenyls", "C0033223#ent", "<e1>", ")", "have", "been", "reported", "to", "involve", "reduced", "C0031306#ent", "<e2>", "which", "could", "be", "related", "to", "increased", "susceptibility", "to", "infections", "."], "h": {"id": "C0033223", "name": "C0033223#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031306", "name": "C0031306#ent", "pos": [18, 19]}}
{"token": ["The", "degraded", "products", "of", "C0003015#ent", "<e1>", "bacterial", "activity", "the", "electrochemical", "behavior", "of", "C1418648#ent", "<e2>", "5LX", "steel", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418648", "name": "C1418648#ent", "pos": [12, 13]}}
{"token": ["No", "immunologic", "relationship", "confirmed", "between", "the", "inhibitor", "and", "other", "well-known", "C0003015#ent", "<e1>", "as", "alpha", "1-antitrypsin", "alpha", "2-macroglobulin", "alpha", "1-antichymotrypsin", "antithrombin", "III", "C1-in-activator", ",", "and", "C1418648#ent", "<e2>"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418648", "name": "C1418648#ent", "pos": [24, 25]}}
{"token": ["Using", "the", "polymerase", "chain", "reaction", "sequence-specific", "oligonucleotide", "probes", "we", "have", "determined", "the", "distribution", "of", "the", "C0002085#ent", "<e1>", "at", "the", "polymorphic", "class", "II", "loci", "C1837204#ent", "<e2>", ",", "DQA1", ",", "DQB1", ",", "and", "DPB1", "in", "25", "patients", "with", "Lyme", "arthritis"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1837204", "name": "C1837204#ent", "pos": [23, 24]}}
{"token": ["By", "combining", "the", "analysis", "of", "C0002085#ent", "<e1>", "variations", "at", "C1837204#ent", "<e2>", ",", "DRB3", ",", "and", "DQB1", "loci", ",", "we", "can", "detect", "33", "different", "DR-DQ", "combinations", "in", "our", "panel", "of", "Caucasoid", "individuals", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1837204", "name": "C1837204#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "the", "present", "study", "aimed", "to", "assess", "the", "role", "of", "C0289313#ent", "<e1>", "in", "ET-1-mediated", "activation", "of", "c-Jun", "amino-terminal", "kinase", "JNK", ")", "and", "C0082529#ent", "<e2>", "ERK", ")", "1/2", "."], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [23, 24]}}
{"token": ["Reactive", "oxygen", "species", "C0289313#ent", "<e1>", ")", "activate", "Ras", "and", "the", "C0082529#ent", "<e2>", "ERK", ")", "cascade", "."], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [10, 11]}}
{"token": ["Both", "selective", "COX-2", "inhibitor", "celecoxib", ")", "and", "C1257954#ent", "<e1>", "aspirin", ")", "decreased", "the", "rigidity", "of", "C0242422#ent", "<e2>", "rats", "p<0.05", "but", "rigidity", "recovery", "after", "administration", "the", "selective", "COX-2", "inhibitor", "was", "more", "than", "C1257954#ent", "<e1>"], "h": {"id": "C1257954", "name": "C1257954#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [15, 16]}}
{"token": ["The", "C1705709#ent", "<e1>", "not", "co-immunoprecipitated", "with", "C1333355#ent", "<e2>", "in", "any", "cell", "strain"], "h": {"id": "C1705709", "name": "C1705709#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333355", "name": "C1333355#ent", "pos": [6, 7]}}
{"token": ["The", "two", "clones", "inhibited", "the", "binding", "of", "C1705709#ent", "<e1>", "to", "RPA", ",", "C1333355#ent", "<e2>", ",", "and", "TFIIH", "."], "h": {"id": "C1705709", "name": "C1705709#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333355", "name": "C1333355#ent", "pos": [12, 13]}}
{"token": ["For", "example", ",", "C1136240#ent", "<e1>", "declines", "in", "the", "absence", "of", "C3539947#ent", "<e2>", "can", "not", "be", "stimulated", "by", "insulin", "under", "this", "condition", "."], "h": {"id": "C1136240", "name": "C1136240#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [10, 11]}}
{"token": ["Overexpression", "of", "Dnmt3A", "or", "C1333242#ent", "<e1>", ",", "which", "do", "not", "interact", "with", "C1366837#ent", "<e2>", ",", "yielded", "weaker", "effects", "on", "clonogenicity", "."], "h": {"id": "C1333242", "name": "C1333242#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [12, 13]}}
{"token": ["Indeed", "C1421512#ent", "<e1>", "expression", "relies", "on", "dorsal", "neural", "tube-derived", "Wnt1", ",", "while", "C1414395#ent", "<e2>", "expression", "depends", "on", "the", "presence", "of", "the", "ectoderm", "."], "h": {"id": "C1421512", "name": "C1421512#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414395", "name": "C1414395#ent", "pos": [12, 13]}}
{"token": ["The", "modified", "flavin", "was", "eliminated", "by", "expression", "of", "the", "recombinant", "C0027203#ent", "<e1>", "in", "the", "presence", "of", "C0268563#ent", "<e2>", ",", "the", "same", "reagent", "used", "to", "induce", "expression", "of", "the", "natural", "enzyme"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268563", "name": "C0268563#ent", "pos": [16, 17]}}
{"token": ["Heterotetrameric", "sarcosine", "oxidase", "TSOX", ")", "is", "a", "complex", "bifunctional", "C0027203#ent", "<e1>", "that", "catalyzes", "the", "oxidation", "of", "the", "methyl", "group", "C0268563#ent", "<e2>", "(", "N-methylglycine", ")", "and", "transfer", "of", "the", "oxidized", "methyl", "group", "into", "the", "one-carbon", "metabolic", "pool"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268563", "name": "C0268563#ent", "pos": [19, 20]}}
{"token": ["A", "single", "amino", "acid", "replacing", "Ala", "(", "C1423891#ent", "<e1>", ")", "at", "position", "401", "with", "Glu", "(", "C1414899#ent", "<e2>", ")", "showed", "that", "Ala-401", "in", "the", "third", "WW", "domain", "a", "protein", "interaction", "module", "is", "not", "conserved", "in", "the", "domain", "."], "h": {"id": "C1423891", "name": "C1423891#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414899", "name": "C1414899#ent", "pos": [16, 17]}}
{"token": ["C0850666#ent", "<e1>", "been", "assumed", "to", "be", "the", "underlying", "cause", "of", "some", "C0018939#ent", "<e2>", "as", ",", "chronic", "urticaria"], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [11, 12]}}
{"token": ["Our", "case", "indicates", "that", "gastric", "lesions", "induced", "by", "C0850666#ent", "<e1>", "play", "an", "important", "role", "in", "C0018939#ent", "<e2>"], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [15, 16]}}
{"token": ["The", "vehicles", "evaluated", "were", "polyethylene", "glycol", "400", "propylene", "glycol", "C0012403#ent", "<e1>", "DMSO", ")", ",", "C12-C15", "alcohol", "lactates", ",", "C0091724#ent", "<e2>", "butyrolactone", ",", "methylpyrrolidone", ",", "hexyl", "laurate", "isopropyl", "myristate", "and", "caprylic/capric", "triglyceride", "(", "Neobee", "M5", ")", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0091724", "name": "C0091724#ent", "pos": [18, 19]}}
{"token": ["Recombinants", "of", "this", "virus", "have", "been", "constructed", "which", "include", "the", "C0040078#ent", "<e1>", "herpes", "simplex", "virus", "type", "1", "a", "downstream", "linkage", "with", "the", "C0080058#ent", "<e2>", "Harvey", "murine", "sarcoma", "virus"], "h": {"id": "C0040078", "name": "C0040078#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [22, 23]}}
{"token": ["C1412216#ent", "<e1>", "is", "a", "C0014442#ent", "<e2>", "for", "GluR2", "pre-mRNA", "editing", "Q/R", "site-607", ",", "which", "gates", "Ca2", "+", "entry", "through", "AMPA", "receptor", "channels"], "h": {"id": "C1412216", "name": "C1412216#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}}
{"token": ["C1705240#ent", "<e1>", "is", "a", "C0751870#ent", "<e2>", "by", "expansion", "of", "a", "trinucleotide", "CAG", "repeat", "which", "encodes", "the", "polyglutamine", "tract", "in", "the", "first", "exon", "of", "the", "androgen", "receptor", "AR", ")", "gene", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [4, 5]}}
{"token": ["Spinal", "and", "bulbar", "muscular", "atrophy", "C1705240#ent", "<e1>", ")", "is", "a", "heritable", "C0751870#ent", "<e2>", "by", "the", "expansion", "of", "a", "polyglutamine", "[", "poly(Q", ")", "]", "repeat", "within", "the", "androgen", "receptor", "AR", ")", "protein", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [11, 12]}}
{"token": ["These", "data", "represent", "evidence", "that", "C0919445#ent", "<e1>", "inhibits", "PC-induced", "bone", "matrix", "remodeling", "and", "induces", "C3811118#ent", "<e2>", "glandular", "redifferentiation", "."], "h": {"id": "C0919445", "name": "C0919445#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [14, 15]}}
{"token": ["Previously", ",", "we", "showed", "that", "C0919445#ent", "<e1>", ",", "a", "serine", "protease", "inhibitor", "specifically", "inhibits", "PC-associated", "uPA", "and", "C3811118#ent", "<e2>", "cell", "invasion", "motility", "in", "vitro"], "h": {"id": "C0919445", "name": "C0919445#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [17, 18]}}
{"token": ["MYF5", "and", "C1417533#ent", "<e1>", "were", "assigned", "to", "5q13", ",", "C1425289#ent", "<e2>", "to", "5q23", "and", "MMP19", "to", "5q25", "."], "h": {"id": "C1417533", "name": "C1417533#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1425289", "name": "C1425289#ent", "pos": [9, 10]}}
{"token": ["Because", "unconventional", "C0969681#ent", "<e1>", "participate", "in", "cellular", "processes", "from", "membrane", "trafficking", "signaling", "and", "cell", "motility", "C1417556#ent", "<e2>", "an", "attractive", "CLP", "target", "."], "h": {"id": "C0969681", "name": "C0969681#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417556", "name": "C1417556#ent", "pos": [15, 16]}}
{"token": ["Studies", "in", "vivo", "that", "co-translational", "regulation", "the", "viral", "coat", "C0035685#ent", "<e1>", "been", "uncoupled", "in", "C0042720#ent", "<e2>", "deletion", "delta", "159", "."], "h": {"id": "C0035685", "name": "C0035685#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042720", "name": "C0042720#ent", "pos": [14, 15]}}
{"token": ["This", "process", "is", "thought", "to", "involve", "an", "unconventional", "mechanism", "involving", "the", "premature", "termination", "the", "virally", "encoded", "C0035685#ent", "<e1>", "it", "is", "copying", "the", "C0042720#ent", "<e2>"], "h": {"id": "C0035685", "name": "C0035685#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042720", "name": "C0042720#ent", "pos": [22, 23]}}
{"token": ["Studies", "of", "primary", "microglia", "and", "astrocytes", "from", "neonatal", "mice", "have", "revealed", "that", "S.", "aureus", "one", "of", "the", "main", "etiologic", "agents", "C0006105#ent", "<e1>", "humans", ",", "is", "a", "potent", "stimulus", "for", "C0243042#ent", "<e2>"], "h": {"id": "C0006105", "name": "C0006105#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0243042", "name": "C0243042#ent", "pos": [29, 30]}}
{"token": ["These", "C0079941#ent", "<e1>", "have", "no", "significant", "sequence", "similarity", "known", "C0086376#ent", "<e2>", ",", "which", "complicates", "the", "task", "of", "functional", "study", "these", "C0086376#ent", "<e2>", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["To", "prevent", "ventricular", "tachycardia", "when", "treatment", "is", "indicated", "for", "ventricular", "premature", "beats", "ajmaline", ",", "propafenon", ",", "C0034414#ent", "<e1>", ",", "disopyramid", "or", "C0543459#ent", "<e2>", ",", "occasionally", "in", "combination", "with", "a", "beta-adrenergic", "blocker", "be", "employed", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [21, 22]}}
{"token": ["In", "a", "randomized", ",", "crossover", "study", "the", "hemodynamic", "responses", "to", "single", "oral", "doses", "C0034414#ent", "<e1>", "(", "600", "mg", ")", "and", "C0543459#ent", "<e2>", "(", "400", "mg", ")", "were", "compared", "in", "20", "patients", "with", "marked", "left", "ventricular", "dysfunction"], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [20, 21]}}
{"token": ["Here", ",", "we", "use", "chromatin", "immunoprecipitation", "C1420492#ent", "<e1>", ")", "to", "determine", "if", "C1417250#ent", "<e2>", ",", "Tel1p", ",", "or", "Mec1p", "affects", "telomere", "maintenance", "by", "promoting", "recruitment", "of", "telomerase", "subunits", "S.", "cerevisiae", "telomeres", "."], "h": {"id": "C1420492", "name": "C1420492#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417250", "name": "C1417250#ent", "pos": [12, 13]}}
{"token": ["C1956346#ent", "<e1>", "defined", "by", "self-report", "of", "angina", "myocardial", "infarction", "\"", "C0155668#ent", "<e2>"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0155668", "name": "C0155668#ent", "pos": [10, 11]}}
{"token": ["The", "purpose", "of", "these", "studies", "was", "to", "determine", "the", "role", "of", "cytochrome", "P450", "isoforms", "the", "biotransformation", "of", "C0085173#ent", "<e1>", "and", "C0085173#ent", "<e1>", "C0001975#ent", "<e1>", "."], "h": {"id": "C0085173", "name": "C0085173#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [22, 23]}}
{"token": ["However", ",", "FRET", "imaging", "C1421482#ent", "<e1>", "activation", "levels", "of", "cells", "expressing", "Exo70", "and/or", "constitutively", "active", "C3715042#ent", "<e2>", "reveals", "that", "this", "complex", "locally", "antagonises", "the", "NGF-induced", "activation", "of", "C1421482#ent", "<e1>", "in", "membrane", "protrusions"], "h": {"id": "C1421482", "name": "C1421482#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3715042", "name": "C3715042#ent", "pos": [15, 16]}}
{"token": ["We", "presented", "a", "rare", "case", "of", "tetanic", "crisis", "in", "a", "23-year", "old", "mentally", "retarded", "woman", "with", "C0014544#ent", "<e1>", "after", "treatment", "by", "C0069751#ent", "<e2>", ",", "the", "new", "anticonvulsant", "agent"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0069751", "name": "C0069751#ent", "pos": [21, 22]}}
{"token": ["From", "January", "1991", "until", "October", "1994", ",", "the", "present", "authors", "treated", "40", "patients", "with", "intellectual", "disability", "C0014544#ent", "<e1>", "under", "the", "age", "of", "18", "years", "with", "C0069751#ent", "<e2>", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0069751", "name": "C0069751#ent", "pos": [25, 26]}}
{"token": ["Glutathione", "peroxidase", "catalase", ",", "superoxide", "dismutase", "malondialdehyde", "activities", "investigated", "in", "a", "control", "group", "15", "normal", "healthy", ")", "and", "a", "group", "of", "13", "C0014544#ent", "<e1>", "patients", ",", "before", "and", "after", "1", "year", "of", "C0069751#ent", "<e2>", "treatment", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [22, 23]}, "relation": "may_be_treated_by", "t": {"id": "C0069751", "name": "C0069751#ent", "pos": [32, 33]}}
{"token": ["The", "effect", "of", "intracarotid", "arterial", "infusions", "C0699222#ent", "<e1>", "GTN", ")", ",", "a", "substance", "known", "to", "precipitate", "C0042376#ent", "<e2>", "on", "the", "spontaneous", "activity", "trigeminal", "neurons", "with", "craniovascular", "input", "was", "studied", "in", "cats", "."], "h": {"id": "C0699222", "name": "C0699222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042376", "name": "C0042376#ent", "pos": [16, 17]}}
{"token": ["The", "use", "of", "deep", "brain", "stimulation", "DBS", ")", "has", "recently", "been", "expanding", "for", "the", "treatment", "of", "many", "C0027765#ent", "<e1>", "as", "Parkinson", "disease", "dystonia", ",", "essential", "tremor", "C0040517#ent", "<e2>", "cluster", "headache", "epilepsy", ",", "depression", ",", "and", "obsessive", "compulsive", "disorder"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [26, 27]}}
{"token": ["It", "is", "currently", "thought", "that", "genetic", "predisposition", "imbalances", "in", "dopaminergic", "transmission", "underlie", "several", "C0027765#ent", "<e1>", "including", "schizophrenia", ",", "manic", "depression", "C0040517#ent", "<e2>", "Parkinson", "disease", "Huntington", "disease", "and", "alcohol", "abuse"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [20, 21]}}
{"token": ["The", "properties", "and", "physiological", "effects", "three", "currently", "FDA-approved", "thrombolytic", "agents", "streptokinase", "(", "C1414057#ent", "<e1>", ")", ",", "tissue", "plasminogen", "activator", "tPA", ")", ",", "and", "C0078956#ent", "<e2>", "APSAC", ")", "are", "reviewed", "."], "h": {"id": "C1414057", "name": "C1414057#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [23, 24]}}
{"token": ["In", "C0700349#ent", "<e1>", "anaesthetised", "dogs", ",", "C0066477#ent", "<e2>", "(", "a", "neuroleptic", "butyrophenone", "reduced", "mean", "aortic", "blood", "pressure", "and", "at", "lower", "doses", "0.5", "and", "2.5", "mg", "."], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0066477", "name": "C0066477#ent", "pos": [6, 7]}}
{"token": ["The", "C0083402#ent", "<e1>", "and", ",", "to", "a", "lesser", "extent", ",", "C0643807#ent", "<e2>", "were", "substrates", "for", "pancreatic", "carboxypeptidase", "B.", "MTX-arg", "was", "also", "hydrolyzed", "by", "the", "endogenous", "carboxypeptidase", "N", "human", "serum", "."], "h": {"id": "C0083402", "name": "C0083402#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0643807", "name": "C0643807#ent", "pos": [10, 11]}}
{"token": ["The", "temporal", "profiles", "for", "the", "regulation", "of", "Cdk5", "and", "C2983131#ent", "<e1>", "transcripts", "were", "different", ",", "suggesting", "that", "these", "changes", "in", "C0812327#ent", "<e2>", "be", "regulated", "by", "different", "mechanism", "."], "h": {"id": "C2983131", "name": "C2983131#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [20, 21]}}
{"token": ["The", "differential", "diagnosis", "be", "made", "with", "other", "dermatoses", ",", "such", "as", "tinea", ",", "C0011615#ent", "<e1>", "psoriasis", ",", "dyshidrosis", ",", "and", "C0085656#ent", "<e2>"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085656", "name": "C0085656#ent", "pos": [20, 21]}}
{"token": ["There", "was", "release", "of", "mitochondrial", "cytochrome", "c", "the", "cytosol", "and", "activation", "of", "C0291573#ent", "<e1>", "which", "were", "prevented", "by", "C0010592#ent", "<e2>", ",", "diallylsulfide", ",", "and", "Trolox", "."], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [18, 19]}}
{"token": ["C1539291#ent", "<e1>", ",", "an", "imprinted", "putative", "tumor", "suppressor", "gene", "encodes", "a", "M(r", ")", "26,000", "C0086376#ent", "<e2>", "is", "60", "%", "homologous", "to", "ras", "and", "rap", "but", "has", "a", "dramatically", "different", "function", "."], "h": {"id": "C1539291", "name": "C1539291#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}}
{"token": ["C1321567#ent", "<e1>", "be", "expected", "following", "administration", "of", "diuretics", "(", "especially", "with", "C0541746#ent", "<e2>", ",", "diazoxide", ",", "beta-adrenergic", "stimulants", "(", "tocolytics", ")", ",", "glucocorticoids", ",", "and", "prolactin", "."], "h": {"id": "C1321567", "name": "C1321567#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0541746", "name": "C0541746#ent", "pos": [11, 12]}}
{"token": ["C1335212#ent", "<e1>", "alterations", "frequently", "coexisted", "with", "PTEN", "or", "C1537502#ent", "<e2>", "changes", "."], "h": {"id": "C1335212", "name": "C1335212#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [8, 9]}}
{"token": ["Immunoreactive", "C1706334#ent", "<e1>", "perikarya", "and", "fibers", "in", "the", "middle-aged", "C0003128#ent", "<e2>", "females", "did", "not", "differ", "in", "their", "distribution", "in", "the", "basal", "forebrain", "those", "of", "young", "cycling", "females", "."], "h": {"id": "C1706334", "name": "C1706334#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003128", "name": "C0003128#ent", "pos": [9, 10]}}
{"token": ["The", "C1420212#ent", "<e1>", "uptake", "of", "C0267964#ent", "<e2>", "was", "not", "affected", "by", "the", "inclusion", "of", "indol-3yl-acetic", "acid", "(", "IAA", ")", "in", "the", "uptake", "medium", "up", "to", "approx", "."], "h": {"id": "C1420212", "name": "C1420212#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0267964", "name": "C0267964#ent", "pos": [5, 6]}}
{"token": ["They", "also", "provide", "support", "for", "the", "hypothesis", "that", "heparin", "interferes", "with", "the", "expression", "of", "certain", "C1947941#ent", "<e1>", "required", "for", "C3888088#ent", "<e2>", "migration", "and", "proliferation", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [19, 20]}}
{"token": ["C1565860#ent", "<e1>", ",", "a", "key", "mediator", "of", "inflammation", ",", "is", "upregulated", "in", "activated", "C1413347#ent", "<e2>", ",", "suggesting", "that", "C1565860#ent", "<e1>", "inhibition", "might", "reduce", "atherogenesis", "through", "its", "anti-inflammatory", "effects"], "h": {"id": "C1413347", "name": "C1413347#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [0, 1]}}
{"token": ["At", "any", "stimulatory", "antigen", "density", "C1704877#ent", "<e1>", "increased", "the", "fraction", "of", "responding", "cells", "and/or", "C1333196#ent", "<e2>", "amounts", "produced", "by", "individual", "cells", "without", "affecting", "TCR", "down-regulation", "."], "h": {"id": "C1704877", "name": "C1704877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [14, 15]}}
{"token": ["A", "variety", "of", "drugs", "effective", "against", "clinical", "C0004238#ent", "<e1>", ",", "including", "flecainide", ",", "propafenone", ",", "procainamide", ",", "and", "C0037707#ent", "<e2>", ",", "have", "been", "found", "to", "terminate", "experimental", "C0004238#ent", "<e1>", "."], "h": {"id": "C0037707", "name": "C0037707#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [7, 8]}}
{"token": ["Many", "clinicians", "choose", "C0037707#ent", "<e1>", "for", "the", "prevention", "of", "recurrences", "of", "atrial", "fibrillation", "C0004238#ent", "<e2>", ")", "as", "an", "alternative", "to", "quinidine", ",", "which", "has", "been", "associated", "with", "increase", "in", "long-term", "mortality", "."], "h": {"id": "C0037707", "name": "C0037707#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [13, 14]}}
{"token": ["C0023524#ent", "<e1>", "is", "required", "for", "C1366479#ent", "<e2>", "caspase", "3", "activation", "upon", "exposure", "to", "stimuli", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366479", "name": "C1366479#ent", "pos": [5, 6]}}
{"token": ["Physical", "exercise-related", "stress", "activates", "hypothalamus-pituitary-adrenal", "(HPA)", "axis", "nitric", "oxide", "one", "of", "the", "C0127400#ent", "<e1>", "of", "the", "HPA", "axis", "response", "to", "stress", ",", "and", "C1318700#ent", "<e2>", "influences", "nitric", "oxide-linked", "biological", "activities"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1318700", "name": "C1318700#ent", "pos": [23, 24]}}
{"token": ["The", "C3540471#ent", "<e1>", "was", "to", "evaluate", "whether", "preventive", "treatment", "C0076829#ent", "<e2>", "in", "patients", "with", "episodic", "migraine", "reduces", "the", "risk", "of", "developing", "chronic", "forms", "headache", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [9, 10]}}
{"token": ["Fever", "in", "C0010340#ent", "<e1>", "patients", "is", "often", "treated", "with", "C0003419#ent", "<e2>", "or", "physical", "cooling", "methods", "."], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [9, 10]}}
{"token": ["A", "case", "of", "neonatal", "C1318711#ent", "<e1>", "discussed", "that", "presented", "as", "C1535939#ent", "<e2>", ",", "with", "subsequent", "development", "of", "skin", "lesions"], "h": {"id": "C1318711", "name": "C1318711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [10, 11]}}
{"token": ["Bovine", "endometrial", "adenylate", "cyclase", "to", "respond", "to", "C0282210#ent", "<e1>", "but", "was", "stimulated", "by", "C3540754#ent", "<e2>", "E(1", ")", "and", "E(2)"], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [13, 14]}}
{"token": ["Ubiquitin-specific", "proteases", "UBPs", ")", "are", "a", "family", "of", "unique", "C0043376#ent", "<e1>", "that", "specifically", "remove", "C1305923#ent", "<e2>", "covalently", "linked", "via", "peptide", "or", "isopeptide", "bonds", "to", "the", "C-terminal", "glycine", "ubiquitin", "."], "h": {"id": "C0043376", "name": "C0043376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}}
{"token": ["C0762592#ent", "<e1>", "specifically", "decreased", "C1333897#ent", "<e2>", ",", "but", "not", "HIF-1beta", "protein", "."], "h": {"id": "C0762592", "name": "C0762592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [4, 5]}}
{"token": ["C0246569#ent", "<e1>", "itself", "induced", "C1705633#ent", "<e2>", "activation", ",", "which", "was", "not", "further", "enhanced", "by", "ATII", "."], "h": {"id": "C0246569", "name": "C0246569#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [4, 5]}}
{"token": ["C0010964#ent", "<e1>", "formed", "3.5", "%", "of", "our", "cases", "of", "C0020255#ent", "<e2>"], "h": {"id": "C0010964", "name": "C0010964#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020255", "name": "C0020255#ent", "pos": [9, 10]}}
{"token": ["Succinylacetone", "(", "C1825840#ent", "<e1>", ")", "is", "a", "specific", "marker", "for", "the", "inherited", "metabolic", "disease", "C0268490#ent", "<e2>"], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268490", "name": "C0268490#ent", "pos": [14, 15]}}
{"token": ["We", "used", "Theiler's", "murine", "encephalomyelitis", "virus", "TMEV", ")", ",", "which", "induces", "C0338474#ent", "<e1>", "maps", "genetically", "to", "the", "D", "region", "C0017355#ent", "<e2>", "is", "associated", "with", "levels", "of", "Class", "I", "products"], "h": {"id": "C0338474", "name": "C0338474#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [19, 20]}}
{"token": ["Although", "cDNAs", "encoding", "the", "previously", "identified", "melanoma", "Ags", ",", "C0041484#ent", "<e1>", "and", "gp100", ",", "were", "isolated", ",", "these", "C1705743#ent", "<e2>", "were", "found", "to", "recognize", "previously", "unidentified", "peptides", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705743", "name": "C1705743#ent", "pos": [18, 19]}}
{"token": ["Significant", "similarity", "was", "found", "between", "a", "C3275243#ent", "<e1>", "encoded", "by", "an", "early", "region", "ORF", "and", "the", "C1333360#ent", "<e2>", "(", "essential", "recombination", "function", ")", "gene", "product", "Salmonella", "phage", "P22"], "h": {"id": "C3275243", "name": "C3275243#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333360", "name": "C1333360#ent", "pos": [16, 17]}}
{"token": ["Among", "the", "C0242708#ent", "<e1>", ",", "methotrexate", "(", "MTX", ")", "is", "considered", "the", "C1254351#ent", "<e2>", "should", "be", "used", "first", "in", "patients", "as", "risk", "of", "developing", "persistent", "disease", "."], "h": {"id": "C0242708", "name": "C0242708#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["RA", "patients", "should", "be", "started", "with", "C0242708#ent", "<e1>", "as", "early", "as", "possible", "and", "among", "multiple", "C0242708#ent", "<e1>", "methotrexate", "(", "MTX", ")", "is", "considered", "the", "C1254351#ent", "<e1>", "should", "be", "used", "first", "."], "h": {"id": "C0242708", "name": "C0242708#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [24, 25]}}
{"token": ["There", "are", "many", "who", "feel", "that", "the", "achievement", "of", "a", "C0242708#ent", "<e1>", "(", "DM", ")", "designation", "for", "a", "C1254351#ent", "<e2>", "is", "an", "important", "goal", "in", "Alzheimer", "disease", "AD", ")", "therapeutics", "."], "h": {"id": "C0242708", "name": "C0242708#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["C1839163#ent", "<e1>", "occurred", "in", "3/7", "patients", "treated", "with", "C0879590#ent", "<e2>", "alone", ",", "and", "in", "none", "of", "those", "treated", "with", "C0879590#ent", "<e2>", "plus", "melatonin", ";", "this", "difference", "was", "statistically", "significant"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [8, 9]}}
{"token": ["Most", "randomized", "trials", "only", "included", "prematurely", "born", "infants", "who", "have", "respiratory", "distress", "syndrome", "C1421210#ent", "<e1>", ")", "or", "infants", "who", "have", "severe", "C1145670#ent", "<e2>"], "h": {"id": "C1421210", "name": "C1421210#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [21, 22]}}
{"token": ["Twenty", "neonates", "with", "C1421210#ent", "<e1>", ",", "heralded", "by", "C1145670#ent", "<e2>", "necessitated", "the", "initiation", "of", "oxygen", "inhalation", "therapy", "ventilatory", "support", "24", "hours", "of", "birth", ",", "were", "enrolled", "in", "the", "study", "."], "h": {"id": "C1421210", "name": "C1421210#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [8, 9]}}
{"token": ["A", "girl", "was", "described", "with", "an", "unusual", "combination", "of", "C0242292#ent", "<e1>", "polyostotic", "fibrotic", "dysplasia", "hyperpigmentations", "on", "the", "skin", "and", "precocious", "puberty", "with", "C0020550#ent", "<e2>", ",", "hypophosphatemic-hyperphosphaturic", "rickets", "acromegaly", "."], "h": {"id": "C0242292", "name": "C0242292#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [22, 23]}}
{"token": ["For", "example", ",", "C2983397#ent", "<e1>", "expression", "enhances", "the", "binding", "of", "C1335580#ent", "<e2>", "to", "XRCC3", "and", "to", "HsRad51D", ",", "and", "C1335580#ent", "<e2>", "expression", "allows", "the", "indirect", "interaction", "of", "C2983397#ent", "<e1>", "with", "Rad51D", "."], "h": {"id": "C2983397", "name": "C2983397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335580", "name": "C1335580#ent", "pos": [10, 11]}}
{"token": ["Nucleoli", "in", "erythroblasts", "were", "visualized", "by", "a", "simple", "cytochemical", "procedure", "the", "demonstration", "of", "RNA", "which", "facilitated", "the", "visualization", "not", "only", "large", "C1417613#ent", "<e1>", "but", "also", "micronucleoli", "in", "advanced", "stages", "the", "C0002875#ent", "<e2>"], "h": {"id": "C1417613", "name": "C1417613#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0002875", "name": "C0002875#ent", "pos": [30, 31]}}
{"token": ["Thus", ",", "lithium", "and", "C0037567#ent", "<e1>", "are", "potential", "drugs", "for", "treating", "some", "forms", "of", "C0751870#ent", "<e2>"], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [14, 15]}}
{"token": ["The", "enzyme", "content", "was", "studied", "by", "estimation", "of", "the", "LDH", "C0022173#ent", "<e1>", "distribution", "and", "the", "enzymes", "of", "the", "purine", "metabolism", "ADA", "and", "C1418856#ent", "<e2>", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418856", "name": "C1418856#ent", "pos": [22, 23]}}
{"token": ["Advanced", "prostate", "cancer", "heterogeneous", ";", "therefore", ",", "the", "validity", "of", "PSA", "decline", "as", "a", "measurable", "end", "point", "was", "studied", "in", "advanced", "human", "prostate-cancer", "cell", "lines", ":", "C1857728#ent", "<e1>", "LNCaP", "and", "androgen-insensitive", "C1704969#ent", "<e2>"], "h": {"id": "C1857728", "name": "C1857728#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1704969", "name": "C1704969#ent", "pos": [31, 32]}}
{"token": ["C1442753#ent", "<e1>", "and", "mutants", "that", "interacted", "with", "beta1", "integrins", "increased", "both", "focal", "adhesion", "formation", "C1704657#ent", "<e2>", "and", "AKT", "phosphorylation", "."], "h": {"id": "C1442753", "name": "C1442753#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704657", "name": "C1704657#ent", "pos": [14, 15]}}
{"token": ["An", "intrapulmonary", "percussive", "ventilator", "(", "IPV", ")", "improves", "airway", "clearance", "and", "lung", "function", "and", "is", "useful", "for", "wide", "variety", "of", "C0035204#ent", "<e1>", "such", "as", "cystic", "fibrosis", "chronic", "obstructive", "pulmonary", "disease", "aspiration", "pneumonia", "and", "C0027868#ent", "<e2>"], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [33, 34]}}
{"token": ["At", "later", "times", ",", "C0011967#ent", "<e1>", "content", "showed", "a", "faster", "decrease", "in", "C1095795#ent", "<e2>", "761-treated", "rats", "."], "h": {"id": "C0011967", "name": "C0011967#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1095795", "name": "C1095795#ent", "pos": [12, 13]}}
{"token": ["Methylene", "blue", "C0733397#ent", "<e1>", "and", "the", "C3658209#ent", "<e2>", "parabromophenacyl", "bromide", ",", "inhibited", "melittin-induced", "relaxations", ",", "while", "the", "cyclo-oxygenase", "inhibitor", "indomethacin", ",", "was", "without", "effect", "."], "h": {"id": "C0733397", "name": "C0733397#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3658209", "name": "C3658209#ent", "pos": [6, 7]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "investigate", "the", "effects", "of", "bone", "morphogenetic", "protein-7", "BMP-7", ")", ",", "also", "named", "C1445625#ent", "<e1>", "OP-1", ")", ",", "on", "the", "progression", "of", "a", "C0085196#ent", "<e2>", "6-OHDA", ")", "lesion", "."], "h": {"id": "C1445625", "name": "C1445625#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0085196", "name": "C0085196#ent", "pos": [28, 29]}}
{"token": ["This", "is", "mainly", "performed", "by", "a", "member", "of", "the", "C1314771#ent", "<e1>", "(", "a", "disintegrin", "and", "metalloproteinase", ")", "family", "of", "C0014442#ent", "<e2>", ",", "TNF-alpha-converting", "enzyme", "TACE", ",", "ADAM", "17", "."], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [19, 20]}}
{"token": ["Growing", "evidence", "supports", "a", "key", "role", "of", "the", "C3494976#ent", "<e1>", "in", "many", "neuroinflammatory", "conditions", ",", "including", "C0025297#ent", "<e2>", ",", "encephalitis", ",", "brain", "tumors", "cerebral", "ischemia", "Guillain-Barr\u00e9", ",", "and", "multiple", "sclerosis", "MS", ")", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [16, 17]}}
{"token": ["Compare", "the", "efficacy", "of", "isradipine", "to", "that", "of", "C0028005#ent", "<e1>", "for", "the", "control", "of", "C0020538#ent", "<e2>", "coronary", "artery", "bypass", "graft", "CABG", ")", "."], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [14, 15]}}
{"token": ["The", "elevated", "expression", "of", "C1429589#ent", "<e1>", "reflected", "as", "an", "increased", "expression", "of", "the", "Le(x)", "CD65s", "C0796126#ent", "<e2>", "on", "PMN", "from", "these", "individuals", "."], "h": {"id": "C1429589", "name": "C1429589#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [15, 16]}}
{"token": ["Use", "of", "metoclopramide", "in", "premedication", "for", "or", "induction", "of", "anaesthesia", "to", "eliminate", "the", "C0007681#ent", "<e1>", "effect", "of", "C1161352#ent", "<e2>", "on", "the", "LOS", "pressure", "appears", "to", "be", "indicated", "."], "h": {"id": "C0007681", "name": "C0007681#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [17, 18]}}
{"token": ["T.Q.-induced", "cardiovascular", "C0007681#ent", "<e1>", "effects", "were", "significantly", "antagonized", "by", "C1161352#ent", "<e2>", "and", "cyproheptadine", "but", "not", "by", "reserpine", "."], "h": {"id": "C0007681", "name": "C0007681#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [9, 10]}}
{"token": ["The", "attachment", "of", "mPEG", "to", "C1413662#ent", "<e1>", "substantially", "improved", "the", "stability", "of", "the", "C0014442#ent", "<e2>", "with", "respect", "to", "the", "specific", "peptidase", "activity", "the", "model", "substrate", "."], "h": {"id": "C1413662", "name": "C1413662#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["Several", "cataractogenic", "factors", "are", "involved", "in", "BMT", ",", "such", "as", "ionizing", "irradiation", "C3536709#ent", "<e1>", "treatment", ",", "and", "C0729502#ent", "<e2>"], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [17, 18]}}
{"token": ["To", "date", ",", "germline", "mutations", "been", "found", "in", "three", "candidate", "C0017337#ent", "<e1>", "for", "hereditary", "prostate", "cancer", "ELAC2", "at", "17p11", ",", "C1419413#ent", "<e2>", "at", "1q25", "and", "MSR1", "at", "8p22", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419413", "name": "C1419413#ent", "pos": [20, 21]}}
{"token": ["The", "enzymes", "which", "comprise", "the", "2',5'-oligoadenylate", "synthetase", "OAS", ")", "family", "are", "interferon", "(", "IFN", ")", "stimulated", "C0017337#ent", "<e1>", "which", "regulate", "C1419413#ent", "<e2>", "antiviral", "responses", "may", "play", "additional", "roles", "in", "control", "of", "cellular", "growth", "differentiation", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419413", "name": "C1419413#ent", "pos": [20, 21]}}
{"token": ["NO", "precursor", "L-arginine", "and", "NO", "donors", "C0037533#ent", "<e1>", "S-nitroso-N-acetylpenicillamine", "potentiated", "the", "hyperalgesia", "and", "allodynia", "significantly", "suggesting", "C0728960#ent", "<e2>", "effect", "in", "neuropathic", "rats", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [16, 17]}}
{"token": ["Polyomavirus", "JCV", ",", "BKV", "and", "C1456377#ent", "<e1>", "have", "been", "associated", "with", "C0019151#ent", "<e2>", "in", "both", "HIV-positive", "and", "HIV-negative", "patients", "."], "h": {"id": "C1456377", "name": "C1456377#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [11, 12]}}
{"token": ["And", "when", "C0144300#ent", "<e1>", "was", "administered", "to", "the", "patients", "of", "C0015765#ent", "<e2>", "fecal", "drug", "and", "their", "correlation", "to", "the", "changes", "in", "the", "fecal", "microflora", "investigated", "."], "h": {"id": "C0144300", "name": "C0144300#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015765", "name": "C0015765#ent", "pos": [10, 11]}}
{"token": ["It", "is", "hoped", "that", "this", "study", "would", "have", "increased", "the", "awareness", "that", "C0018784#ent", "<e1>", "is", "a", "common", "complication", "of", "C0018790#ent", "<e2>", "in", "our", "patients", "."], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018790", "name": "C0018790#ent", "pos": [19, 20]}}
{"token": ["C0041188#ent", "<e1>", "is", "a", "group", "of", "C0009450#ent", "<e2>", "muscle", "tissue"], "h": {"id": "C0041188", "name": "C0041188#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [6, 7]}}
{"token": ["Acute", "conditions", "associated", "with", "noncirrhotic", "intrahepatic", "portal", "hypertension", "acute", "(", "and", "particularly", "C0302809#ent", "<e1>", ")", "viral", "or", "drug-induced", "hepatitis", "acute", "alcoholic", "hepatitis", "acute", "veno-occlusive", "disease", "and", "C4025020#ent", "<e2>"], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4025020", "name": "C4025020#ent", "pos": [26, 27]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "evaluate", "the", "arterial", "hemodynamics", "patients", "with", "C0011860#ent", "<e1>", "impaired", "glucose", "tolerance", "clinical", "or", "Doppler", "evidence", "of", "C1704436#ent", "<e2>", "in", "order", "to", "early", "detect", "vascular", "damage"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [23, 24]}}
{"token": ["Seventy-six", "C0011860#ent", "<e1>", "patients", "free", "of", "C1704436#ent", "<e2>", "82", "age-matched", "healthy", "volunteers", "studied", "by", "means", "of", "transcutaneous", "oxygen", "pressure", "measurements", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [6, 7]}}
{"token": ["We", "investigated", "the", "relationship", "of", "AGEs", ",", "MDA", ",", "total", "reactive", "antioxidant", "potentials", "(", "TRAPs", ")", ",", "and", "vitamin", "E", "C0011860#ent", "<e1>", "patients", "with", "and", "without", "C1704436#ent", "<e2>", "PAD", ")", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1704436", "name": "C1704436#ent", "pos": [26, 27]}}
{"token": ["Similarly", ",", "mRNA", "abundance", "for", "C0001022#ent", "<e1>", "the", "glucose", "transport", "proteins", "Glut", "1", "Glut", "4", "not", "affected", "by", "C1705328#ent", "<e2>", "in", "either", "adipose", "depot", "."], "h": {"id": "C0001022", "name": "C0001022#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [18, 19]}}
{"token": ["C0077681#ent", "<e1>", "(", "UCN-01", ")", ",", "a", "non-selective", "inhibitor", "of", "C0033634#ent", "<e2>", "PKC", ")", ",", "and", "phorbol", "ester", "PMA", ")", ",", "a", "PKC", "activator", "are", "undergoing", "clinical", "evaluations"], "h": {"id": "C0077681", "name": "C0077681#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [10, 11]}}
{"token": ["UCN-01", "(", "C0077681#ent", "<e1>", ",", "isolated", "from", "Streptomyces", "sp.", "is", "a", "selective", "inhibitor", "of", "C0033634#ent", "<e2>", "antitumor", "activity"], "h": {"id": "C0077681", "name": "C0077681#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [14, 15]}}
{"token": ["C0077681#ent", "<e1>", "(", "UCN-01", ")", "is", "a", "potent", "inhibitor", "of", "C0033634#ent", "<e2>", "PKC", ")", "isozymes", "alpha", "beta", ",", "and", "gamma", "[", "Seynaeve", "et", "al.", ",", "Mol", "."], "h": {"id": "C0077681", "name": "C0077681#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [10, 11]}}
{"token": ["Bicuculline", "and", "C0000477#ent", "<e1>", "decreased", "whilst", "C0114721#ent", "<e2>", "increased", "the", "mean", "size", "the", "clusters", "."], "h": {"id": "C0000477", "name": "C0000477#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0114721", "name": "C0114721#ent", "pos": [6, 7]}}
{"token": ["Of", "the", "presumably", "four", "genes", ",", "the", "C0079429#ent", "<e1>", "encoding", "the", "C3537330#ent", "<e2>", "a", "processed", "(pseudo)gene", "of", "the", "catalytic", "subunit", "alpha", "been", "characterized", "completely", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537330", "name": "C3537330#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "C0006230#ent", "<e1>", "on", "neuroleptic-induced", "endocrinological", "disturbances", "(", "amenorrhea", ",", "C3665358#ent", "<e2>", "and", "impotence", ")", "were", "investigated", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C3665358", "name": "C3665358#ent", "pos": [12, 13]}}
{"token": ["The", "PF-Unit", "has", "been", "tested", "in", "a", "few", "patients", "with", "hepatic", "failure", "Grades", "III", "C0206019#ent", "<e1>", "and", "respiratory", ",", "and", "C1565662#ent", "<e2>"], "h": {"id": "C0206019", "name": "C0206019#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [20, 21]}}
{"token": ["The", "results", "of", "this", "study", "indicate", "that", "the", "C1738886#ent", "<e1>", "null", "genotype", "protective", "against", "C0340293#ent", "<e2>", ",", "an", "effect", "that", "is", "more", "marked", "in", "smokers", "."], "h": {"id": "C1738886", "name": "C1738886#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [14, 15]}}
{"token": ["MAP", "kinase", "cascade", "activated", "by", "ras", ",", "70kDaS6", "C0031727#ent", "<e1>", "lying", "downstream", "of", "C2713509#ent", "<e2>", ",", "and", "the", "regulation", "of", "glycogen", "synthase", "been", "discussed", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "C0795858#ent", "<e1>", "a", "clinically", "recognizable", "C1848862#ent", "<e2>", "."], "h": {"id": "C0795858", "name": "C0795858#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [8, 9]}}
{"token": ["C0030424#ent", "<e1>", "Pw", ")", ",", "a", "common", "C0043528#ent", "<e2>", "Asia", ",", "is", "typically", "associated", "with", "eosinophilia", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [7, 8]}}
{"token": ["C0030424#ent", "<e1>", "is", "a", "common", "C0043528#ent", "<e2>", "China", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [5, 6]}}
{"token": ["In", "the", "present", "study", ",", "this", "approach", "was", "applied", "to", "predict", "the", "prophylactic", "efficacy", "of", "the", "C0242896#ent", "<e1>", "caramiphen", "in", "combination", "with", "C0034262#ent", "<e2>", "in", "man", "based", "on", "animal", "data"], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034262", "name": "C0034262#ent", "pos": [22, 23]}}
{"token": ["Gluten-free", "diet", "C1851112#ent", "<e1>", ")", "protects", "against", "the", "complications", "of", "celiac", "disease", "C1705969#ent", "<e2>", ")", "."], "h": {"id": "C1851112", "name": "C1851112#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [12, 13]}}
{"token": ["A", "strict", "gluten-free", "diet", "C1851112#ent", "<e1>", ")", "for", "life", "is", "the", "only", "treatment", "for", "celiac", "disease", "C1705969#ent", "<e2>", ")", "."], "h": {"id": "C1851112", "name": "C1851112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "the", "effect", "of", "iron", "supplementation", "in", "addition", "to", "gluten", "free", "diet", "C1851112#ent", "<e1>", ")", ",", "on", "hematological", "profile", "of", "children", "with", "Celiac", "Disease", "C1705969#ent", "<e2>", ")", "."], "h": {"id": "C1851112", "name": "C1851112#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [25, 26]}}
{"token": ["C0812269#ent", "<e1>", "promotes", "transcription", "elongation", "many", "C1417679#ent", "<e2>", "and", "functions", "as", "a", "histone", "H3", "chaperone", "alter", "chromatin", "structure", "transcription", "."], "h": {"id": "C0812269", "name": "C0812269#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}}
{"token": ["C0005301#ent", "<e1>", "is", "used", "for", "treatment", "of", "several", "C0042594#ent", "<e2>"], "h": {"id": "C0005301", "name": "C0005301#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042594", "name": "C0042594#ent", "pos": [8, 9]}}
{"token": ["These", "results", "demonstrate", "that", "the", "administration", "of", "a", "C0242912#ent", "<e1>", "eliprodil", ")", "or", "a", "thrombolytic", "agent", "C0032143#ent", "<e2>", ")", "similarly", "reduce", "the", "volume", "of", "brain", "damage", "the", "neurological", "deficit", "a", "rat", "embolic", "stroke", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [16, 17]}}
{"token": ["Additionally", ",", "newly", "developed", "C0242912#ent", "<e1>", "especially", "the", "combined", "effect", "of", "C0032143#ent", "<e2>", "and", "the", "immunosuppressant", ",", "FK506", ",", "on", "an", "embolic", "infarct", "are", "discussed", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [11, 12]}}
{"token": ["C3888277#ent", "<e1>", "transferase", "produces", "A", "antigens", "and", "transfers", "C4283926#ent", "<e2>", "to", "the", "acceptor", "substrate", ",", "H", "structures", "glycolipids", "and", "glycoproteins", "."], "h": {"id": "C3888277", "name": "C3888277#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4283926", "name": "C4283926#ent", "pos": [8, 9]}}
{"token": ["Histo-blood", "group", "C3888277#ent", "<e1>", "produces", "A", "antigens", "and", "transfers", "C4283926#ent", "<e2>", "to", "the", "acceptor", "substrate", ",", "H", "structures", "glycolipids", "and", "glycoproteins", "."], "h": {"id": "C3888277", "name": "C3888277#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283926", "name": "C4283926#ent", "pos": [9, 10]}}
{"token": ["C3888277#ent", "<e1>", "place", "of", "C4283926#ent", "<e2>", "to", "the", "same", "acceptor", "substrate", "to", "synthesize", "B", "antigens"], "h": {"id": "C3888277", "name": "C3888277#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4283926", "name": "C4283926#ent", "pos": [4, 5]}}
{"token": ["Each", "kininase", "activity", "determined", "by", "measuring", "the", "hydrolysis", "of", "bradykinin", "in", "the", "presence", "of", "specific", "inhibitors", "of", "kininase", "I", "C0046305#ent", "<e1>", ",", "kininase", "II", "captopril", ")", "and", "NEP", "(", "C0070915#ent", "<e2>", ")", "in", "8", "normal", "subjects"], "h": {"id": "C0046305", "name": "C0046305#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0070915", "name": "C0070915#ent", "pos": [29, 30]}}
{"token": ["The", "oxygenases", "involved", "in", "the", "degradation", "and", "excretion", "of", "cholesterol", ",", "including", "the", "C0769789#ent", "<e1>", "the", "27-hydroxylase", ",", "are", "enzymes", "of", "the", "C0051169#ent", "<e2>"], "h": {"id": "C0769789", "name": "C0769789#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [22, 23]}}
{"token": ["Sonography", "detected", "all", "cases", "of", "C4284009#ent", "<e1>", "missed", "the", "lesions", "in", "2", "of", "39", "patients", "with", "C0267830#ent", "<e2>"], "h": {"id": "C4284009", "name": "C4284009#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0267830", "name": "C0267830#ent", "pos": [16, 17]}}
{"token": ["Using", "this", "C1705156#ent", "<e1>", "sequence", "the", "gene", "encoding", "C0069718#ent", "<e2>", "oah", ")", "was", "cloned", "by", "inverse", "PCR", "."], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0069718", "name": "C0069718#ent", "pos": [8, 9]}}
{"token": ["Cationic", "isozymes", "accounted", "for", "approximately", "98", "%", "of", "the", "total", "C0027021#ent", "<e1>", "activity", "associated", "with", "C0017837#ent", "<e2>", "only", "A-1", "of", "the", "anionic", "isozymes", "some", "C0027021#ent", "<e1>", "activity", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [10, 11]}}
{"token": ["Vmax", "values", "of", "both", "GSH", "C0017837#ent", "<e1>", "and", "GSH", "C0027021#ent", "<e2>", "activities", "in", "microsomes", "were", "increased", "at", "3", "hr", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [9, 10]}}
{"token": ["Heparinases", "greatly", "reduced", "the", "actions", "of", "C0032999#ent", "<e1>", ",", "indicating", "a", "role", "for", "a", "C1332127#ent", "<e2>", "the", "C-terminus", "of", "C0032999#ent", "<e1>", "receptor", "activation"], "h": {"id": "C1332127", "name": "C1332127#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032999", "name": "C0032999#ent", "pos": [6, 7]}}
{"token": ["Early", "and", "late", "effects", "C0028066#ent", "<e1>", "on", "Aldo", ",", "C3274822#ent", "<e2>", ",", "and", "Aldo/PRA", "ratio", "levels", "studied", "in", "a", "single", "blind", ",", "placebo-controlled", ",", "10-day", "pilot", "study"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [9, 10]}}
{"token": ["These", "data", "indicate", "that", "brain", "trauma", "precipitates", "C0795692#ent", "<e1>", "accumulation", "and", "metabolic", "acidosis", "hemorrhage", ",", "and", "infusion", "of", "C0073385#ent", "<e2>", "relieve", "these", "disturbances", "."], "h": {"id": "C0795692", "name": "C0795692#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0073385", "name": "C0073385#ent", "pos": [18, 19]}}
{"token": ["Ranitidine", "bismuth", "citrate", "Pylorid", ",", "C0650259#ent", "<e1>", ")", "is", "a", "novel", "C1254351#ent", "<e2>", "which", "heals", "peptic", "ulcers", "when", "co-prescribed", "with", "either", "clarithromycin", "or", "amoxycillin", "eradicatesHelicobacter", "pylori"], "h": {"id": "C0650259", "name": "C0650259#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}}
{"token": ["Seventeen", "C0009952#ent", "<e1>", "episodes", "occurred", "in", "24", "patients", "receiving", "ST", "alone", ",", "and", "9", "C0009952#ent", "<e1>", "episodes", "occurred", "in", "29", "patients", "receiving", "ST", "+", "C0008809#ent", "<e1>", "."], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [24, 25]}}
{"token": ["Considering", "these", "results", ",", "it", "does", "not", "appear", "that", "C0009952#ent", "<e1>", "neutropenia", "is", "reduced", "by", "C0008809#ent", "<e2>", "during", "grade", "IV", "neutropenia"], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "acid", "(", "(S)CR", "2249", ")", ",", "a", "new", "chemical", "entity", "among", "a", "series", "of", "C0376182#ent", "<e1>", "were", "investigated", "on", "N-methyl-D-aspartate", "(NMDA)-evoked", "release", "of", "C3887648#ent", "<e2>", "from", "rat", "hippocampal", "slices", "."], "h": {"id": "C0376182", "name": "C0376182#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [26, 27]}}
{"token": ["The", "other", "36", "classifiable", "lesions", "had", "small-intestine", "ALP-like", "activity", "(", "marked", "heat", "and", "C2239920#ent", "<e1>", "sensitivity", ")", "or", "a", "liver", "ALP-like", "C0022173#ent", "<e2>", "(", "marked", "heat", "and", "slight", "C2239920#ent", "<e1>", "sensitivity", ")", "."], "h": {"id": "C2239920", "name": "C2239920#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [21, 22]}}
{"token": ["The", "yeast", "ferroxidase", "Fet3p", ",", "acquires", "copper", "from", "Ccc2p", "and", "can", "not", "function", "if", "Ccc2p", "is", "impaired", ";", "expression", "of", "C2987364#ent", "<e1>", "ATP7B", "in", "ccc2", "yeast", "complements", "the", "C0162316#ent", "<e2>", "phenotype", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [28, 29]}}
{"token": ["These", "genes", "are", "organized", "into", "an", "C0022895#ent", "<e1>", "containing", "aga", "(", "alpha-galactosidase", ")", ",", "galK", "(", "C0016937#ent", "<e2>", ")", ",", "and", "galT", "(", "galactose", "1-phosphate", "uridylyltransferase", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016937", "name": "C0016937#ent", "pos": [16, 17]}}
{"token": ["A", "sixfold", "higher", "steady-state", "level", "of", "C0017916#ent", "<e1>", "in", "euthyroids", "compared", "to", "C3665349#ent", "<e2>", "was", "observed", "at", "a", "pCaF", "of", "5.5", "."], "h": {"id": "C0017916", "name": "C0017916#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [12, 13]}}
{"token": ["The", "total", "activities", "of", "C0017916#ent", "<e1>", "and", "phosphorylase", "phosphatase", "euthyroids", "and", "C3665349#ent", "<e2>", "were", "the", "same", "in", "the", "fraction", "containing", "the", "protein-glycogen", "complex", "(", "P2", "suspension", "."], "h": {"id": "C0017916", "name": "C0017916#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [11, 12]}}
{"token": ["Independent", "of", "allergy", "risk", ",", "there", "was", "a", "significantly", "lower", "prevalence", "of", "C0012634#ent", "<e1>", "children", "with", "cord", "serum", "of", "IgG", "C2825096#ent", "<e2>", "above", "350", "AU/l", "than", "in", "children", "with", "lower", "levels"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2825096", "name": "C2825096#ent", "pos": [20, 21]}}
{"token": ["After", "bilateral", "sympathectomy", "the", "blood", "flow", "microsphere", "method", "was", "increased", "in", "the", "cerebral", "cortex", "thalamus", ",", "and", "mesencephalon", "in", "a", "pressure-dependent", "manner", "in", "the", "face", "of", "C0597048#ent", "<e1>", "as", "compared", "with", "the", "flow", "during", "C0020538#ent", "<e2>"], "h": {"id": "C0597048", "name": "C0597048#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [34, 35]}}
{"token": ["This", "confirms", "a", "previous", "report", "of", "a", "lethal", "synergism", "of", "C0031849#ent", "<e1>", "after", "subacute", "dosing", "with", "C3540800#ent", "<e2>", "."], "h": {"id": "C0031849", "name": "C0031849#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540800", "name": "C3540800#ent", "pos": [16, 17]}}
{"token": ["Cognitive", "functions", "investigated", "in", "seven", "manic", "depressive", "patients", "while", "on", "C3540800#ent", "<e1>", ",", "after", "two", "weeks", "off", "C3540800#ent", "<e1>", ",", "and", "after", "a", "subcutaneous", "injection", "of", "C0031849#ent", "<e1>", "while", "on", "C3540800#ent", "<e1>", "."], "h": {"id": "C0031849", "name": "C0031849#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3540800", "name": "C3540800#ent", "pos": [10, 11]}}
{"token": ["C1419009#ent", "<e1>", "conditioned", "media", "C1419009#ent", "<e1>", "plasma", "membranes", "no", "effect", "on", "the", "abundance", "of", "either", "C1705603#ent", "<e1>", "or", "actin", "mRNA", "."], "h": {"id": "C1419009", "name": "C1419009#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705603", "name": "C1705603#ent", "pos": [15, 16]}}
{"token": ["The", "most", "easily", "biodegradable", "compounds", "ethanol", "and", "C0059747#ent", "<e1>", "used", "primarily", "than", "C0169101#ent", "<e2>", "."], "h": {"id": "C0059747", "name": "C0059747#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [12, 13]}}
{"token": ["To", "our", "knowledge", ",", "this", "is", "the", "first", "time", "that", "C0059747#ent", "<e1>", "gas", "chromatographic", "analysis", "been", "definitely", "demonstrated", "to", "be", "an", "intermediate", "of", "C0169101#ent", "<e2>", "degradation", "."], "h": {"id": "C0059747", "name": "C0059747#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [23, 24]}}
{"token": ["In", "addition", ",", "he", "was", "homozygous", "for", "the", "2938C-->T", "and", "4268G-->C", "mutations", "causing", "296Arg-->Ser", "and", "486Ser-->Thr", "C2917660#ent", "<e1>", "substitution", "found", "in", "the", "C1707217#ent", "<e2>"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1707217", "name": "C1707217#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "C1416998#ent", "<e1>", "suppression", "results", "in", "upregulation", "of", "C0694872#ent", "<e2>", ",", "alpha-catenin", ",", "and", "beta-catenin", "expression", "in", "cells", "."], "h": {"id": "C1416998", "name": "C1416998#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [10, 11]}}
{"token": ["However", ",", "the", "relation", "between", "pulmonary", "hypertension", "Raynaud's", "phenomenon", ",", "pulmonary", "thrombosis", "C0031046#ent", "<e1>", "or", "type", "of", "lupus", "nephritis", "C0024141#ent", "<e2>", "could", "not", "be", "clarified", "with", "a", "significant", "difference", "."], "h": {"id": "C0031046", "name": "C0031046#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [19, 20]}}
{"token": ["C2346627#ent", "<e1>", "interacts", "with", "C2983131#ent", "<e2>", "in", "the", "yeast-two", "hybrid", "system", "binds", "to", "C2983131#ent", "<e2>", "in", "glutathione", "S-transferase", "fusion", "pull-down", "assays", ",", "and", "colocalizes", "with", "C2983131#ent", "<e2>", "in", "cultured", "neurons", "and", "transfected", "cells", "."], "h": {"id": "C2346627", "name": "C2346627#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2983131", "name": "C2983131#ent", "pos": [4, 5]}}
{"token": ["Analysis", "of", "additional", "mutational", "changes", "LIG4", "syndrome", "(", "R580X", ",", "R814X", "and", "G469E", ")", "have", "led", "to", "the", "identification", "of", "a", "nuclear", "localization", "in", "C1442799#ent", "<e1>", "sites", "impacting", "upon", "C1334340#ent", "<e2>"], "h": {"id": "C1442799", "name": "C1442799#ent", "pos": [24, 25]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334340", "name": "C1334340#ent", "pos": [29, 30]}}
{"token": ["C1420357#ent", "<e1>", "(", "40", "microM", ")", ",", "a", "C1514555#ent", "<e2>", "increased", "EGF", "receptor", "affinity", "twofold", "in", "control", "cells", "six-", "to", "nine-fold", "in", "cells", "of", "leprechaunism", "."], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1514555", "name": "C1514555#ent", "pos": [8, 9]}}
{"token": ["This", "effect", "was", "protein", "kinase", "C", ":", "C1420357#ent", "<e1>", ",", "a", "potent", "C1514555#ent", "<e2>", "failed", "to", "block", "H2O2-induced", "VSMC", "DNA", "synthesis"], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1514555", "name": "C1514555#ent", "pos": [12, 13]}}
{"token": ["C1366535#ent", "<e1>", "with", "the", "vasopressin", "type", "1a", "receptor", "C1705363#ent", "<e2>", ")", "to", "initiate", "physiological", "effects", "as", "vasoconstriction", "of", "blood", "vessels", "glycogenolysis", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705363", "name": "C1705363#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "pretreatment", "with", "C0967936#ent", "<e1>", "reduced", "the", "characteristic", "signs", "of", "conduction", "defects", "C0151744#ent", "<e2>", "and", "infarction", "observed", "by", "venom", "injection", "."], "h": {"id": "C0967936", "name": "C0967936#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [13, 14]}}
{"token": ["The", "increase", "in", "intracellular", "Ca2", "+", "may", "activate", "several", "enzymatic", "pathways", "as", "phospholipase", "A2", "metabolism", "of", "archidonic", "acid", "cyclooxygenase", "and", "C0023837#ent", "<e1>", ",", "conversion", "of", "C0043316#ent", "<e2>", "xanthine", "oxidase", "proteases", ",", "and", "activation", "of", "nitric", "oxide", "synthase"], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0043316", "name": "C0043316#ent", "pos": [25, 26]}}
{"token": ["Brefeldin-A", ",", "an", "antibiotic", "that", "inhibits", "exocytosis", "of", "C0086376#ent", "<e1>", ",", "not", "only", "prevented", "C1415287#ent", "<e2>", "trafficking", "to", "the", "membrane", "but", "also", "inhibited", "referred", "hyperalgesia", "in", "capsaicin-treated", "mice", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415287", "name": "C1415287#ent", "pos": [14, 15]}}
{"token": ["C1366557#ent", "<e1>", "treatment", "further", "increased", "the", "synthesis", "of", "NF200", "and", "C1414967#ent", "<e2>", "in", "the", "transfected", "clones", "as", "revealed", "by", "Western", "blot", "analysis"], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414967", "name": "C1414967#ent", "pos": [10, 11]}}
{"token": ["Anaesthesia", "was", "induced", "with", "C0936073#ent", "<e1>", "followed", "by", "suxamethonium", "and/or", "C0001981#ent", "<e2>", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001981", "name": "C0001981#ent", "pos": [10, 11]}}
{"token": ["General", "anesthesia", "maintained", "with", "C0936073#ent", "<e1>", ",", "fentanyl", ",", "N2O/O2", ",", "and", "enflurane", ";", "C0001981#ent", "<e2>", "was", "used", "for", "muscle", "relaxation"], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001981", "name": "C0001981#ent", "pos": [14, 15]}}
{"token": ["In", "the", "intravenous", "induction", "group", "anesthesia", "was", "induced", "with", "C0936073#ent", "<e1>", "and", "orotracheal", "or", "nasotracheal", "intubation", "facilitated", "with", "succinylcholine", "chloride", "C0001981#ent", "<e2>"], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001981", "name": "C0001981#ent", "pos": [20, 21]}}
{"token": ["Increased", "travel", "and", "outdoor", "leisure", "activities", "the", "elderly", "individual", "at", "risk", "for", "infection", "with", "the", "C0026946#ent", "<e1>", "histoplasmosis", ",", "blastomycosis", ",", "C0009186#ent", "<e2>", ",", "and", "sporotrichosis", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [21, 22]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "the", "feasibility", ",", "clinical", "effect", "safety", "of", "intravenous", "thrombolysis", "C0032143#ent", "<e1>", "patients", "with", "acute", "ischaemic", "stroke", "treated", "in", "an", "C0038454#ent", "<e2>"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [27, 28]}}
{"token": ["This", "sequence", "of", "alterations", "accompanying", "early", "PCD", "is", "found", "in", "very", "different", "models", "of", "apoptosis", "induction", ":", "C0661256#ent", "<e1>", "lymphocytes", ",", "activation-induced", "PCD", "of", "T", "cell", "hybridomas", "and", "C1705592#ent", "<e2>", "U937", "cells"], "h": {"id": "C0661256", "name": "C0661256#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [28, 29]}}
{"token": ["Previous", "trials", "vary", "in", "their", "inclusion", "criteria", "both", "in", "terms", "of", "the", "definition", "of", "C0040425#ent", "<e1>", "and", "in", "the", "frequency", "of", "C0242429#ent", "<e2>", "before", "entry", "into", "the", "study", "is", "permitted", "."], "h": {"id": "C0040425", "name": "C0040425#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0242429", "name": "C0242429#ent", "pos": [21, 22]}}
{"token": ["C0360714#ent", "<e1>", "inhibit", "the", "dimerization", "of", "beta-secretase", "[", "C3815269#ent", "<e2>", "(", "beta-site", "amyloid", "precursor", "protein-cleaving", "enzyme", "]", "by", "inhibiting", "the", "lipidation", "of", "C3815269#ent", "<e2>", "and", "associated", "proteins"], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3815269", "name": "C3815269#ent", "pos": [8, 9]}}
{"token": ["The", "development", "of", "C0524928#ent", "<e1>", "dioxide", "retention", "to", "be", "linked", "to", "the", "exaggeration", "of", "C0393777#ent", "<e2>", "changes", "on", "ventilation", "by", "coexistent", "respiratory", "system", "disorders"], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0393777", "name": "C0393777#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "of", "fish", "with", "either", "the", "C0026457#ent", "<e1>", "pargyline", "or", "the", "catecholamine", "(", "CA", ")", "uptake", "blocker", "C0024977#ent", "<e2>", "largely", "prevented", "such", "modifications", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024977", "name": "C0024977#ent", "pos": [17, 18]}}
{"token": ["Numerous", "evidences", "suggest", "that", "focal", "adhesion", "kinase", "C0059239#ent", "<e1>", ")", "is", "involved", "in", "mediating", "this", "C1412097#ent", "<e2>", "effect", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [15, 16]}}
{"token": ["Numerous", "evidences", "suggest", "that", "C0059239#ent", "<e1>", "FAK", ")", "is", "involved", "in", "mediating", "this", "C1412097#ent", "<e2>", "effect", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [13, 14]}}
{"token": ["The", "fractions", "have", "been", "analyzed", "for", "proteins", ",", "DNA", ",", "RNA", ",", "cytochrome", "oxidase", "C0014894#ent", "<e1>", ",", "and", "up", "to", "11", "C0020289#ent", "<e2>"], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [21, 22]}}
{"token": ["Erythropoietic", "proteins", "C0221271#ent", "<e1>", ")", "offer", "an", "effective", "treatment", "of", "C0002871#ent", "<e2>", "ameliorate", "QoL", ",", "although", "their", "use", "requires", "the", "correct", "targeting", "of", "hemoglobin", "increase", "to", "avoid", "thromboembolic", "complications", "."], "h": {"id": "C0221271", "name": "C0221271#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "describe", "the", "detailed", "characterization", "of", "one", "specific", "class", "of", "C0017337#ent", "<e1>", "that", "encode", "the", "C0003693#ent", "<e2>", "LOX", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [17, 18]}}
{"token": ["The", "most", "prominent", "feature", "was", "an", "enhanced", "transcription", "of", "two", "C0017337#ent", "<e1>", ",", "coding", "for", "5-lipoxygenase", "(", "C0003693#ent", "<e2>", ")", "and", "ALOX5-activating", "protein", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [17, 18]}}
{"token": ["However", ",", "site-directed", "mutations", "to", "impair", "C1705556#ent", "<e1>", "binding", "or", "hydrolysis", "did", "not", "detectably", "affect", "Arp7", "or", "C2349178#ent", "<e2>", "function", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2349178", "name": "C2349178#ent", "pos": [17, 18]}}
{"token": ["It", "has", "no", "activity", "as", "a", "C0001109#ent", "<e1>", "as", "a", "C1415082#ent", "<e2>"], "h": {"id": "C0001109", "name": "C0001109#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415082", "name": "C1415082#ent", "pos": [10, 11]}}
{"token": ["Addition", "of", "exogenous", "diacylglycerols", "to", "the", "C0001473#ent", "<e1>", "produced", "an", "inhibition", "of", "the", "C0014442#ent", "<e2>", "similar", "in", "magnitude", "to", "that", "observed", "in", "tissue", "samples", "ischemic", "brain"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["We", "also", "briefly", "review", "the", "current", "understanding", "of", "C1709246#ent", "<e1>", "regards", "to", "expression", "of", "activation", "markers", "to", "the", "C1363984#ent", "<e2>", "TNFR", ")", "gene", "family"], "h": {"id": "C1709246", "name": "C1709246#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1363984", "name": "C1363984#ent", "pos": [18, 19]}}
{"token": ["C1427125#ent", "<e1>", ",", "a", "specific", "C1947941#ent", "<e2>", "for", "LC3", "and", "GABARAP", ",", "catalyzes", "the", "processing", "reaction", "LC3", "and", "GABARAP", "precursors", "to", "mature", "forms", "and", "de-conjugating", "reaction", "of", "the", "modifiers", "from", "phospholipids", "."], "h": {"id": "C1427125", "name": "C1427125#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [5, 6]}}
{"token": ["Ectopic", "expression", "of", "C3540602#ent", "<e1>", "inhibited", "both", "C1332416#ent", "<e2>", "promoter", "activity", "endogenous", "C1332416#ent", "<e2>", "expression", "."], "h": {"id": "C3540602", "name": "C3540602#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [7, 8]}}
{"token": ["The", "reliability", "of", "the", "applied", "method", "for", "the", "demonstration", "of", "C1333217#ent", "<e1>", "demonstrated", "by", "the", "addition", "of", "C0280509#ent", "<e2>", "the", "incubation", "medium"], "h": {"id": "C1333217", "name": "C1333217#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0280509", "name": "C0280509#ent", "pos": [17, 18]}}
{"token": ["Cys-69", "resides", "within", "the", "OPR", ",", "C1418943#ent", "<e1>", ",", "and", "AID", "motif", "C1418921#ent", "<e2>", "at", "the", "binding", "interface", "between", "C1418921#ent", "<e2>", "and", "Par6", "where", "it", "interacts", "with", "Arg-28", "on", "Par6", "."], "h": {"id": "C1418943", "name": "C1418943#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418921", "name": "C1418921#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "the", "mode", "of", "inheritance", "of", "C0042974#ent", "<e1>", "C1264041#ent", "<e2>", ")", "and", "perform", "linkage", "analysis", "C1264041#ent", "<e2>", "and", "coat", "color", "narcolepsy", "in", "a", "colony", "of", "Doberman", "Pinschers", "."], "h": {"id": "C0042974", "name": "C0042974#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C1264041", "name": "C1264041#ent", "pos": [9, 10]}}
{"token": ["We", "found", "that", "calnexin", "associated", "only", "with", "the", "transmembrane", "domains", "while", "C1415764#ent", "<e1>", "associated", "only", "with", "the", "C3814821#ent", "<e2>"], "h": {"id": "C1415764", "name": "C1415764#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3814821", "name": "C3814821#ent", "pos": [17, 18]}}
{"token": ["C1416804#ent", "<e1>", "activity", "did", "not", "change", ",", "while", "C1413353#ent", "<e2>", "activity", "was", "reduced", "by", "25", "%", "(", "P", "=", "0.13", ")", "after", "treatment", "."], "h": {"id": "C1416804", "name": "C1416804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413353", "name": "C1413353#ent", "pos": [8, 9]}}
{"token": ["The", "metabolism", "of", "the", "polyphosphoinositides", ",", "C1368108#ent", "<e1>", "(", "DPI", ")", "and", "triphosphoinositide", "(", "C1420871#ent", "<e2>", ")", ",", "was", "studied", "during", "mediator", "release", "rat", "mast", "cells"], "h": {"id": "C1368108", "name": "C1368108#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420871", "name": "C1420871#ent", "pos": [14, 15]}}
{"token": ["The", "study", "of", "these", "organisms", "received", "a", "recent", "boost", "from", "the", "development", "of", "transient", "transformation", "allowing", "the", "short-term", "expression", "of", "C0017337#ent", "<e1>", "reintroduced", "into", "parasites", "like", "Trypanosoma", "brucei", "the", "causative", "agent", "C0041228#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0041228", "name": "C0041228#ent", "pos": [31, 32]}}
{"token": ["A", "C0017337#ent", "<e1>", "encoding", "thioredoxin", "has", "been", "cloned", "from", "Trypanosoma", "brucei", "the", "causative", "agent", "C0041228#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041228", "name": "C0041228#ent", "pos": [14, 15]}}
{"token": ["C0262494#ent", "<e1>", "in", "up", "to", "30", "%", "of", "patients", "admitted", "with", "C0008325#ent", "<e2>"], "h": {"id": "C0262494", "name": "C0262494#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008325", "name": "C0008325#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "because", "of", "the", "clinical", "similarities", "between", "C0262494#ent", "<e1>", "acute", "nongangrenous", "cholecystitis", "and", "because", "of", "the", "high", "incidence", "of", "C0262494#ent", "<e1>", "our", "group", ",", "early", "surgery", "indicated", "for", "C0008325#ent", "<e1>"], "h": {"id": "C0262494", "name": "C0262494#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008325", "name": "C0008325#ent", "pos": [31, 32]}}
{"token": ["Hyperimmunoglobulinaemia", "D", "syndrome", "C0398691#ent", "<e1>", ")", "is", "defined", "as", "recurrent", "fever", ",", "generalised", "lymphadenitis", "abdominal", "pain", "C0003864#ent", "<e2>", "and", "raised", "polyclonal", "serum", "IgD", ">", "100", "IU/ml", "."], "h": {"id": "C0398691", "name": "C0398691#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [16, 17]}}
{"token": ["The", "C0010927#ent", "<e1>", "score", "correlated", "inversely", "with", "the", "Glasgow", "coma", "score", "C4283742#ent", "<e2>", ")", "(", "p", "<", "0.0001", ")", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4283742", "name": "C4283742#ent", "pos": [11, 12]}}
{"token": ["There", "are", "complex", "patterns", "of", "human", "septin", "gene", "expression", "and", "recently", "it", "has", "been", "found", "that", "alterations", "in", "C1539747#ent", "<e1>", "expression", "are", "seen", "in", "C0012634#ent", "<e2>", "neoplasia", "."], "h": {"id": "C1539747", "name": "C1539747#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["These", "studies", "should", "provide", "a", "useful", "basis", "for", "future", "biophysical", "studies", "C1539747#ent", "<e1>", ",", "including", "the", "structural", "basis", "for", "their", "involvement", "in", "C0012634#ent", "<e2>", "such", "as", "cancer", "and", "neurodegenerative", "disorders"], "h": {"id": "C1539747", "name": "C1539747#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}}
{"token": ["Phenytoin", "is", "often", "used", "to", "control", "status", "C0014544#ent", "<e1>", ",", "but", "its", "water-soluble", "prodrug", "C0284906#ent", "<e2>", ",", "may", "be", "more", "useful", "as", "it", "is", "easier", "to", "administer", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0284906", "name": "C0284906#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "it", "is", "shown", "that", "binding", "of", "C1705718#ent", "<e1>", "to", "Gas6", "induces", "the", "phosphorylation", "and", "ubiquitination", "of", "C1705718#ent", "<e1>", "and", "the", "interaction", "of", "C1705718#ent", "<e1>", "with", "the", "ubiquitin", "ligase", "C0812242#ent", "<e1>", "."], "h": {"id": "C1705718", "name": "C1705718#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812242", "name": "C0812242#ent", "pos": [30, 31]}}
{"token": ["The", "C0030193#ent", "<e1>", "manifestations", "presented", "as", "arthralgia", ",", "C0231528#ent", "<e2>", "or", "episodes", "of", "peri-arthritis", ";", "they", "were", "associated", "with", "phases", "of", "the", "endocrine", "disease", "9", "cases", "(", "45", "%", ")", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [8, 9]}}
{"token": ["They", "also", "suffered", "from", "severe", "headache", ",", "a", "C0030193#ent", "<e1>", "tightness", "of", "the", "chest", ",", "abdominal", "pain", "C0231528#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [17, 18]}}
{"token": ["Mice", "treated", "with", "aminoguanidine", ",", "a", "selective", "inhibitor", "of", "iNOS", ",", "exhibited", "C0006625#ent", "<e1>", "and", "exacerbated", "liver", "pathology", "suggesting", "that", "NO", "limits", "C0669372#ent", "<e2>", "damage", "when", "the", "liver", "is", "first", "exposed", "to", "eggs", "."], "h": {"id": "C0006625", "name": "C0006625#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [22, 23]}}
{"token": ["A", "novel", "proteoglycan", ",", "proteolysis", "inducing", "factor", "(", "PIF", ")", ",", "is", "capable", "of", "inducing", "muscle", "proteolysis", "the", "process", "of", "C0006625#ent", "<e1>", "and", "of", "inducing", "an", "acute", "phase", "response", "human", "C0669372#ent", "<e2>", "."], "h": {"id": "C0006625", "name": "C0006625#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [30, 31]}}
{"token": ["C1414995#ent", "<e1>", "is", "a", "C1417585#ent", "<e2>", "a", "role", "in", "early", "cardiac", "development"], "h": {"id": "C1414995", "name": "C1414995#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417585", "name": "C1417585#ent", "pos": [4, 5]}}
{"token": ["In", "addition", ",", "SK&F", "S-106203", "10", "microM", ")", "did", "not", "inhibit", "C0056696#ent", "<e1>", "C1412691#ent", "<e2>", ")", "activity", "of", "several", "C1412691#ent", "<e2>", "isozymes", "."], "h": {"id": "C0056696", "name": "C0056696#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412691", "name": "C1412691#ent", "pos": [13, 14]}}
{"token": ["DMBT1", "is", "C1334347#ent", "<e1>", "and", "shows", "C1420295#ent", "<e2>", "expression", "and", "secretion", ",", "pointing", "to", "a", "function", "in", "the", "protection", "of", "monolayered", "epithelia", "and", "to", "an", "additional", "function", "in", "the", "differentiation", "of", "multilayered", "epithelia"], "h": {"id": "C1334347", "name": "C1334347#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [6, 7]}}
{"token": ["In", "Case", "1", "C0023860#ent", "<e1>", "was", "the", "initial", "manifestation", "of", "C0054871#ent", "<e2>", ",", "while", "it", "occurred", "in", "Case", "2", "prolonged", "treatment", "with", "an", "alkylating", "agent", "splenic", "irradiation"], "h": {"id": "C0023860", "name": "C0023860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [10, 11]}}
{"token": ["C0034960#ent", "<e1>", "due", "to", "accumulation", "of", "phytanic", "acid", "results", "in", "C0020757#ent", "<e2>", "and", "progressive", "neurologic", "dysfunction"], "h": {"id": "C0034960", "name": "C0034960#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020757", "name": "C0020757#ent", "pos": [10, 11]}}
{"token": ["After", "extensive", "testing", "it", "was", "concluded", "that", "the", "C0021051#ent", "<e1>", "attributed", "to", "the", "combination", "of", "methotrexate", ",", "ethanol", "and", "C0003872#ent", "<e2>", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [19, 20]}}
{"token": ["The", "efficacy", "of", "C0002641#ent", "<e1>", "(", "AQ", ")", "and", "C0700599#ent", "<e2>", "(", "SP", ")", "was", "assessed", "in", "310", "symptomatic", "children", "from", "western", "Kenya", "with", "uncomplicated", "Plasmodium", "falciparum", "malaria", "."], "h": {"id": "C0002641", "name": "C0002641#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0700599", "name": "C0700599#ent", "pos": [9, 10]}}
{"token": ["We", "assessed", "the", "safety", ",", "treatment", "efficacy", "effects", "on", "gametocyte", "carriage", "of", "the", "combination", "of", "artesunate", "plus", "C0002641#ent", "<e1>", "and", "chloroquine", "plus", "C0700599#ent", "<e2>", "in", "children", "."], "h": {"id": "C0002641", "name": "C0002641#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0700599", "name": "C0700599#ent", "pos": [22, 23]}}
{"token": ["C0247194#ent", "<e1>", "is", "a", "novel", "atypical", "C0040615#ent", "<e2>", "which", "acts", "as", "a", "broad", "spectrum", "dopamine/serotonin/norepinephrine", "receptor", "antagonist", "."], "h": {"id": "C0247194", "name": "C0247194#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [6, 7]}}
{"token": ["C0247194#ent", "<e1>", "is", "an", "atypical", "C0040615#ent", "<e2>", "in", "development", "for", "the", "treatment", "of", "schizophrenia", "."], "h": {"id": "C0247194", "name": "C0247194#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [5, 6]}}
{"token": ["The", "aim", "of", "this", "study", "is", "to", "assess", ",", "in", "a", "double", "blind", "fashion", "the", "effect", "of", "C0700583#ent", "<e1>", "on", "the", "pain", "and", "associated", "symptoms", "in", "patients", "with", "C0149931#ent", "<e2>"], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [28, 29]}}
{"token": ["In", "C1568247#ent", "<e1>", "patients", ",", "congenital", "deafness", "combined", "with", "a", "pre-pubertal", "onset", "of", "C0035334#ent", "<e2>", "RP", ")", "and", "severe", "vestibular", "dysfunctions"], "h": {"id": "C1568247", "name": "C1568247#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [13, 14]}}
{"token": ["These", "results", "demonstrate", "that", "OSTalpha", "and", "C2677530#ent", "<e1>", "are", "novel", "FXR", "target", "C1417679#ent", "<e2>", "that", "are", "expressed", "in", "the", "adrenal", "gland", "kidney", ",", "and", "intestine", "."], "h": {"id": "C2677530", "name": "C2677530#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "the", "C0537026#ent", "<e1>", "increases", "the", "risk", "of", "C0947622#ent", "<e2>", "formation", "in", "CF", "."], "h": {"id": "C0537026", "name": "C0537026#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [10, 11]}}
{"token": ["A", "case", "of", "C0348890#ent", "<e1>", "a", "dog", "was", "characterized", "by", "pancytopenia", "and", "C0002874#ent", "<e2>"], "h": {"id": "C0348890", "name": "C0348890#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [12, 13]}}
{"token": ["Occasionally", "it", "is", "difficult", "to", "differentiate", "paroxysmal", "nocturnal", "hemoglobinuria", "PNH", ")", "from", "C0348890#ent", "<e1>", "patients", "who", "present", "with", "pancytopenia", "and", "an", "C0002874#ent", "<e2>"], "h": {"id": "C0348890", "name": "C0348890#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [21, 22]}}
{"token": ["The", "mechanism", "of", "transport", "of", "C1742019#ent", "<e1>", "five", "other", "C0282284#ent", "<e2>", "the", "human", "erythrocyte", "membrane", "investigated", "."], "h": {"id": "C1742019", "name": "C1742019#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0282284", "name": "C0282284#ent", "pos": [9, 10]}}
{"token": ["C0020823#ent", "<e1>", "is", "an", "C2267007#ent", "<e2>", "has", "demonstrated", "activity", "against", "non-small", "cell", "lung", "cancer", "testicular", "cancer", "breast", "cancer", "and", "soft", "tissue", "sarcoma"], "h": {"id": "C0020823", "name": "C0020823#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2267007", "name": "C2267007#ent", "pos": [4, 5]}}
{"token": ["In", "the", "present", "study", ",", "the", "relative", "activities", "Fut4", "and", "C1414870#ent", "<e1>", "for", "Lex", "synthesis", "determined", "using", "recombinant", "C3541394#ent", "<e2>", "."], "h": {"id": "C1414870", "name": "C1414870#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}}
{"token": ["Defects", "in", "insulin", "secretion", "a", "common", "feature", "of", "C3273872#ent", "<e1>", "and", "as", "such", "the", "C0061355#ent", "<e2>", "a", "candidate", "for", "contributing", "to", "the", "development", "of", "this", "clinically", "and", "genetically", "heterogeneous", "disorder", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0061355", "name": "C0061355#ent", "pos": [14, 15]}}
{"token": ["One", "possible", "therapeutic", "agent", "C3273872#ent", "<e1>", "is", "the", "C0061355#ent", "<e2>", "GLP-1", ")", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0061355", "name": "C0061355#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "demonstrate", "that", "biologically", "relevant", "doses", "of", "ultraviolet", "A", "UVA", ")", "generate", "C0812281#ent", "<e1>", "in", "cultured", "cells", "6-TG-substituted", "DNA", "and", "that", "C0039902#ent", "<e2>", "and", "UVA", "are", "synergistically", "mutagenic", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [22, 23]}}
{"token": ["Geldanamycin", "and", "herbimycin", "A", "like", "C0085752#ent", "<e1>", ",", "were", "reductively", "activated", "by", "the", "C0027310#ent", "<e2>", "formed", "reactive", ".OH", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027310", "name": "C0027310#ent", "pos": [13, 14]}}
{"token": ["C1332735#ent", "<e1>", "predominantly", "phosphorylated", "Ser38", ",", "while", "MAPK", "and", "C1705633#ent", "<e2>", "MAPKdelta", "predominantly", "phosphorylated", "Ser25", "."], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [9, 10]}}
{"token": ["Far-Western", "analysis", "coimmunoprecipitation", "experiments", "were", "used", "to", "demonstrate", "that", "C1414358#ent", "<e1>", "directly", "interacts", "with", "C1414351#ent", "<e2>", ",", "eIF4A", ",", "and", "eIF3", "."], "h": {"id": "C1414358", "name": "C1414358#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414351", "name": "C1414351#ent", "pos": [14, 15]}}
{"token": ["They", "may", "be", "present", "in", "immunodeficiency", "disorders", "C0026946#ent", "<e1>", "and", "other", "C0009450#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [11, 12]}}
{"token": ["The", "present", "study", "examined", "protein", "kinase", "A", "PKA", ")", "and", "protein", "kinase", "C", "PKC", ")", "involvement", "in", "the", "maintenance", "of", "cellular", "tolerance", "C3537230#ent", "<e1>", "from", "chronic", "opiate", "exposure", "in", "neurosecretory", "cells", "the", "hypothalamic", "arcuate", "nucleus", "C1854562#ent", "<e2>", ")", "."], "h": {"id": "C3537230", "name": "C3537230#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1854562", "name": "C1854562#ent", "pos": [35, 36]}}
{"token": ["Interestingly", ",", "restoration", "was", "only", "possible", "by", "simultaneous", "supplementation", "with", "(S)-3,5-dihydroxyphenylglycine", "and", "C0134352#ent", "<e1>", ",", "indicating", "that", "the", "C0002594#ent", "<e2>", "is", "essential", "for", "the", "formation", "of", "both", "amino", "acids"], "h": {"id": "C0134352", "name": "C0134352#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [18, 19]}}
{"token": ["Common", "clinical", "manifestations", "fever", ",", "articular", "symptoms", ",", "purpura", ",", "glomerulonephritis", ",", "C0151445#ent", "<e1>", "phenomenon", ",", "erythematomacular", "cutaneous", "eruption", "polyneuritis", "and", "C0000737#ent", "<e2>"], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [21, 22]}}
{"token": ["Two", "C1417679#ent", "<e1>", "with", "sequence", "homology", "those", "encoding", "C1335554#ent", "<e2>", "cloned", "from", "genomic", "DNA", "Mycobacterium", "tuberculosis", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [8, 9]}}
{"token": ["RUN", "domains", "are", "present", "in", "several", "proteins", "that", "are", "linked", "particularly", "to", "the", "functions", "of", "C0018296#ent", "<e1>", "in", "the", "C1416920#ent", "<e2>", "and", "Rab", "families"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1416920", "name": "C1416920#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "have", "investigated", "whether", "a", "C0033681#ent", "<e1>", "PYK2", ",", "is", "functionally", "involved", "in", "C0248813#ent", "<e2>", "JNK", ")", "activation", "in", "vascular", "smooth", "muscle", "cells", "VSMCs", ")", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [15, 16]}}
{"token": ["They", "support", "authors", "'", "hypothesis", "that", "testosterone-induced", "rise", "of", "hypothalamic", "C3536742#ent", "<e1>", "content", "in", "newborn", "female", "rats", "is", "evoked", "by", "the", "C2936882#ent", "<e2>", "metabolites", "of", "testosterone", "."], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [21, 22]}}
{"token": ["Chs6p", "belongs", "to", "a", "family", "of", "four", "C0086376#ent", "<e1>", "that", "we", "have", "named", "C0047101#ent", "<e2>", "for", "Chs5p-Arf1p-binding", "Proteins", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0047101", "name": "C0047101#ent", "pos": [13, 14]}}
{"token": ["Epidemiological", "evidence", "suggests", "a", "relation", "between", "C0012177#ent", "<e1>", "intake", "and", "C0022650#ent", "<e2>", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", "to", "the", "experiments", "with", "menadione", ",", "the", "alloxan-enhanced", "reduction", "of", "C3540545#ent", "<e1>", "was", "significantly", "inhibited", "by", "C0144153#ent", "<e2>", "."], "h": {"id": "C3540545", "name": "C3540545#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0144153", "name": "C0144153#ent", "pos": [18, 19]}}
{"token": ["In", "Alzheimer", "disease", "AD", ")", ",", "downregulation", "of", "C0025250#ent", "<e1>", "has", "been", "suggested", "to", "contribute", "to", "the", "development", "of", "C0085220#ent", "<e2>", "CAA", ")", "."], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085220", "name": "C0085220#ent", "pos": [19, 20]}}
{"token": ["The", "study", "reports", "also", "four", "cases", "of", "hepatic", "vein", "thrombosis", "C0019154#ent", "<e1>", "--", "Venoocclusive", "disease", "and", "three", "cases", "of", "benign", "hepatic", "tumors", "liver", "cell", "adenoma", "C0700636#ent", "<e2>", "in", "young", "women", "2-", "to", "5-year", "treatment", "with", "oral", "contraceptive", "steroids"], "h": {"id": "C0019154", "name": "C0019154#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0700636", "name": "C0700636#ent", "pos": [25, 26]}}
{"token": ["DmMKLP1", "has", "no", "known", "close", "relatives", "in", "the", "Drosophila", "genome", "and", "can", "therefore", "be", "assumed", "to", "be", "the", "ortholog", "of", "human", "C1416697#ent", "<e1>", "and", "hamster", "CHOI", "C3541291#ent", "<e2>"], "h": {"id": "C1416697", "name": "C1416697#ent", "pos": [21, 22]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3541291", "name": "C3541291#ent", "pos": [26, 27]}}
{"token": ["C1426213#ent", "<e1>", "interacts", "with", "C1539748#ent", "<e2>", "and", "NCK", "through", "distinct", "domains", "."], "h": {"id": "C1426213", "name": "C1426213#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539748", "name": "C1539748#ent", "pos": [4, 5]}}
{"token": ["Variably", "pruritic", "focal", "areas", "of", "alopecia", ",", "exudation", ",", "and", "crusting", "suggest", "differential", "diagnoses", "C1302323#ent", "<e1>", "furunculosis", ",", "dermatophilosis", ",", "C0040247#ent", "<e2>", ",", "and", "coccidioimycosis", "."], "h": {"id": "C1302323", "name": "C1302323#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [20, 21]}}
{"token": ["An", "extended-release", "formulation", "C0125988#ent", "<e1>", "(", "CER", ")", "has", "been", "developed", "to", "provide", "effective", "C0037763#ent", "<e2>", "relief", "with", "once-daily", "dosing", "."], "h": {"id": "C0125988", "name": "C0125988#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0037763", "name": "C0037763#ent", "pos": [14, 15]}}
{"token": ["C1608295#ent", "<e1>", "is", "a", "good", "and", "reliable", "C0728960#ent", "<e2>", "in", "short", "operations", "in", "operations", "longer", "than", "one", "and", "a", "half", "hours", "catheter", "technique", "adrenaline", "addition", "or", "local", "anaesthetics", "longer", "duration", "ought", "to", "be", "used", "."], "h": {"id": "C1608295", "name": "C1608295#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [7, 8]}}
{"token": ["C1334864#ent", "<e1>", "has", "68", "%", "homology", "to", "the", "C1332163#ent", "<e2>", "Nck", "and", "has", "similar", "but", "distinct", "binding", "specificities", "in", "K562", "lysates", "."], "h": {"id": "C1334864", "name": "C1334864#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332163", "name": "C1332163#ent", "pos": [8, 9]}}
{"token": ["A", "total", "of", "20", "patients", "with", "C0022346#ent", "<e1>", "randomized", "to", "receive", "either", "mannitol", "or", "C0037553#ent", "<e2>", "surgery", "."], "h": {"id": "C0022346", "name": "C0022346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037553", "name": "C0037553#ent", "pos": [14, 15]}}
{"token": ["The", "positive", "C0033978#ent", "<e1>", "Valproinat", "and", "Carbamazepin", ",", "and", "probably", "also", "of", "C0031507#ent", "<e2>", ",", "consists", "in", "the", "acceleration", "of", "the", "psychic", "and", "motor", "rate", "in", "the", "reduction", "of", "viscosity", "and", "perseveration", "."], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [12, 13]}}
{"token": ["Correlation", "of", "half", "of", "the", "sites", "binding", "with", "negative", "cooperativity", "for", "C1291208#ent", "<e1>", "the", "utilization", "of", "low-Kd", "2-oxoglutarate", "sites", "NH3-dependent", "C0017787#ent", "<e2>"], "h": {"id": "C1291208", "name": "C1291208#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017787", "name": "C0017787#ent", "pos": [20, 21]}}
{"token": ["NADP+-isocitrate", "dehydrogenase", "NADP+-IDH", ";", "EC", "1.1.1.42", "is", "involved", "in", "the", "supply", "of", "C1291208#ent", "<e1>", "for", "ammonia", "assimilation", "glutamate", "synthesis", "higher", "plants", "through", "the", "C0017787#ent", "<e2>", "GS/GOGAT", ")", "cycle", "."], "h": {"id": "C1291208", "name": "C1291208#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017787", "name": "C0017787#ent", "pos": [23, 24]}}
{"token": ["The", "results", "indicate", "that", "the", "photoinduced", "degradation", "of", "D1", "(", "and", "C1415944#ent", "<e1>", ")", "does", "not", "involve", "exogenous", "C0030940#ent", "<e2>", "but", "is", "most", "likely", "an", "autoproteolytic", "process"], "h": {"id": "C1415944", "name": "C1415944#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [18, 19]}}
{"token": ["The", "mean", "BMD", "values", "in", "subjects", "with", "C0039292#ent", "<e1>", "dysfunction", "corresponded", "to", "C0029453#ent", "<e2>", ",", "while", "in", "the", "control", "group", "were", "within", "normal", "limits"], "h": {"id": "C0039292", "name": "C0039292#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029453", "name": "C0029453#ent", "pos": [12, 13]}}
{"token": ["Osteosarcoma", "(", "OS", ")", "is", "the", "most", "prevalent", "malignant", "tumor", "cases", "of", "Rothmund-Thomson", "syndrome", "C0032339#ent", "<e1>", ")", "with", "germline", "mutations", "the", "RECQL4", "gene", "a", "member", "of", "the", "C1335669#ent", "<e2>"], "h": {"id": "C0032339", "name": "C0032339#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335669", "name": "C1335669#ent", "pos": [27, 28]}}
{"token": ["Since", "the", "sweat", "test", "often", "unreliable", "in", "C0013604#ent", "<e1>", "the", "possibility", "of", "C0010674#ent", "<e2>", "be", "considered", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [12, 13]}}
{"token": ["C1136254#ent", "<e1>", "metronidazole", ",", "Secnidazole", ",", "C0040263#ent", "<e2>", "and", "Minocycline", "were", "100", "%", "sensitive", ",", "followed", "by", "Chloramphenicol", ",", "Clarithromycin", "and", "Roxithromycin", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [0, 1]}, "relation": "therapeutic_class_of", "t": {"id": "C0040263", "name": "C0040263#ent", "pos": [6, 7]}}
{"token": ["Many", "studies", "report", "uptake", "of", "raft", "molecules", "caveolar", "endocytosis", "defined", "by", "sensitivity", "to", "C0151718#ent", "<e1>", "to", "overexpression", "of", "a", "specific", "mutant", "of", "C1414120#ent", "<e2>", "."], "h": {"id": "C0151718", "name": "C0151718#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [22, 23]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "whether", "patients", "with", "C0520679#ent", "<e1>", "an", "increase", "in", "C0003850#ent", "<e2>", "indicators", "at", "the", "carotid", "artery", "level", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [16, 17]}}
{"token": ["However", ",", "the", "involvement", "of", "C1620185#ent", "<e1>", "in", "the", "metabolism", "of", "C0543459#ent", "<e2>", "has", "been", "proposed", "based", "on", "the", "interaction", "with", "theophylline", "which", "is", "mainly", "metabolized", "by", "C1620185#ent", "<e1>", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [11, 12]}}
{"token": ["On", "the", "other", "hand", ",", "C1620185#ent", "<e1>", "seems", "to", "be", "implicated", "in", "the", "N-oxidation", "of", "C0543459#ent", "<e2>", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "learning", "on", "the", "perceptual-motor", "tasks", "was", "not", "correlated", "with", "habit", "learning", "the", "classification", "C0310298#ent", "<e1>", "in", "either", "the", "C3891714#ent", "<e2>", "or", "healthy", "control", "."], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3891714", "name": "C3891714#ent", "pos": [21, 22]}}
{"token": ["Alterations", "of", "RyR2", "function", "due", "to", "C1419782#ent", "<e1>", "binding", "was", "assessed", "via", "analysis", "of", "C1413043#ent", "<e2>", "+", "-spark", "characteristics", "."], "h": {"id": "C1419782", "name": "C1419782#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [14, 15]}}
{"token": ["Importantly", ",", "we", "demonstrate", "that", "C1538153#ent", "<e1>", "is", "required", "for", "transcriptional", "repression", "the", "methylated", "C1417406#ent", "<e2>", "locus", "."], "h": {"id": "C1538153", "name": "C1538153#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417406", "name": "C1417406#ent", "pos": [14, 15]}}
{"token": ["Both", "insulin-like", "growth", "factor", "binding", "protein-3", "IGFBP-3", ")", "and", "C1515406#ent", "<e1>", "TGF-beta", ")", "have", "been", "separately", "shown", "to", "have", "C1332691#ent", "<e2>", "growth-inhibiting", "or", "growth-potentiating", "effects", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [19, 20]}}
{"token": ["C3889380#ent", "<e1>", ",", "like", "pre-menstrual", "headache", "and", "pill", "withdrawal", "C0270697#ent", "<e2>", "may", "represent", "a", "further", "example", "of", "the", "triggering", "effect", "that", "a", "fall", "in", "sex", "hormone", "level", "has", "on", "the", "migraine", "diathesis"], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [9, 10]}}
{"token": ["Although", "83", "%", "of", "those", "with", "C3889380#ent", "<e1>", "had", "a", "migraine", "diathesis", "they", "did", "not", "describe", "their", "C0270697#ent", "<e2>", "as", "one", "of", "their", "usual", "migraines", "as", "it", "was", "considerably", "milder", "."], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "substantial", "amounts", "of", "molecules", "with", "electrophoretic", "mobility", "to", "CD16", "(", "50", "-", "66", "C1839259#ent", "<e1>", ")", "were", "co-precipitated", "with", "C3889400#ent", "<e2>", "and", "gamma", "chain", "mAb", "from", "lysates", "depleted", "of", "CD16", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3889400", "name": "C3889400#ent", "pos": [21, 22]}}
{"token": ["Inhibition", "of", "cytokine-mediated", "I", "kappa", "B", "alpha", "proteolysis", "using", "the", "protease", "inhibitors", "-phenylalanine", "C0002512#ent", "<e1>", "N-acetyl-L", "-leucinyl-L", "-leucinyl-norleucinal", "also", "inhibited", "cytokine-mediated", "early", "expression", "of", "C1706544#ent", "<e2>", "."], "h": {"id": "C0002512", "name": "C0002512#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [24, 25]}}
{"token": ["In", "this", "paper", ",", "we", "discuss", "how", "C1412765#ent", "<e1>", "participate", "in", "fundamental", "C0033713#ent", "<e2>", "and", "growth-suppressive", "networks", "and", "may", "play", "a", "wider", "role", "in", "cancer", "pathogenesis"], "h": {"id": "C1412765", "name": "C1412765#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033713", "name": "C0033713#ent", "pos": [12, 13]}}
{"token": ["Metvan", "is", "much", "more", "effective", "than", "the", "standard", "C0729502#ent", "<e1>", "dexamethasone", "and", "C0042679#ent", "<e2>", "in", "inducing", "apoptosis", "in", "primary", "leukaemia", "cells", "patients", "with", "acute", "lymphoblastic", "leukaemia", "acute", "myeloid", "leukaemia", "chronic", "acute", "myeloid", "leukaemia"], "h": {"id": "C0729502", "name": "C0729502#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [12, 13]}}
{"token": ["Cats", "infected", "with", "fully", "virulent", "FIV-Petaluma", "strongly", "seroconverted", ",", "became", "persistently", "C0042749#ent", "<e1>", ",", "and", "exhibited", "lymphadenopathy", ",", "C0027947#ent", "<e2>", ",", "and", "inversion", "of", "the", "CD4+:CD8", "+", "T", "cell", "ratio", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [18, 19]}}
{"token": ["We", "here", "demonstrate", "that", "C1332399#ent", "<e1>", "is", "a", "target", "of", "the", "ARF", "C0079427#ent", "<e2>"], "h": {"id": "C1332399", "name": "C1332399#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [12, 13]}}
{"token": ["Group", "I", "patients", "with", "Friedreich's", "ataxia", "FA", ")", ",", "group", "II", "of", "patients", "with", "C0262404#ent", "<e1>", "and", "group", "III", "those", "with", "C0262404#ent", "<e1>"], "h": {"id": "C0262404", "name": "C0262404#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0262404", "name": "C0262404#ent", "pos": [14, 15]}}
{"token": ["Either", "single", "injections", "or", "10", "days", "of", "C0040610#ent", "<e1>", "treatment", "dose-dependently", "elevated", "PWL", "of", "C0003864#ent", "<e2>", "rats", "while", "ketanserin", "could", "partially", "antagonize", "the", "C0040610#ent", "<e1>", "analgesic", "effect"], "h": {"id": "C0040610", "name": "C0040610#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [14, 15]}}
{"token": ["Rational", "antithrombotic", "treatment", "C0035326#ent", "<e1>", "a", "marked", "advance", "in", "the", "therapeutic", "results", ",", "C1418854#ent", "<e2>", "."], "h": {"id": "C0035326", "name": "C0035326#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418854", "name": "C1418854#ent", "pos": [13, 14]}}
{"token": ["The", "Antihypertensive", "and", "Lipid-Lowering", "Treatment", "to", "Prevent", "Heart", "Attack", "Trial", "ALLHAT", ")", "compared", "four", "antihypertensive", "agents", "patients", "55", "years", "and", "older", ":", "chlorthalidone", ",", "C0114873#ent", "<e1>", ",", "amlodipine", ",", "and", "C0065374#ent", "<e2>", "."], "h": {"id": "C0114873", "name": "C0114873#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [30, 31]}}
{"token": ["Thus", ",", "the", "the", "extreme", "fluctuations", "of", "plasma", "cortisol", "levels", "are", "most", "probably", "due", "to", "unexplained", "C3540540#ent", "<e1>", "changes", "of", "C1704793#ent", "<e2>", "secretion", "."], "h": {"id": "C3540540", "name": "C3540540#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [20, 21]}}
{"token": ["Despite", "their", "C3540540#ent", "<e1>", "patterns", ",", "AVP", "and", "C1704793#ent", "<e2>", "secretions", "were", "closely", "coupled", "on", "cross-correlation", "analysis"], "h": {"id": "C3540540", "name": "C3540540#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [8, 9]}}
{"token": ["Thus", "RYSV", "provides", "the", "first", "example", "in", "the", "C0206751#ent", "<e1>", "a", "small", "C0013570#ent", "<e2>", "between", "the", "G", "and", "L", "genes", "encodes", "a", "virion", "protein"], "h": {"id": "C0206751", "name": "C0206751#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [12, 13]}}
{"token": ["In", "all", "cases", ",", "no", "significant", "in", "pancreatic", "spermidine", "C0031957#ent", "<e1>", "concentration", ",", "DNA", "and", "protein", "content", "or", "C0030304#ent", "<e2>", "and", "body", "weight", "observed", "."], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030304", "name": "C0030304#ent", "pos": [18, 19]}}
{"token": ["In", "the", "present", "study", ",", "the", "in", "vitro", "in", "vivo", "effects", "of", "the", "C1254351#ent", "<e1>", "on", "NK", "cell", "have", "been", "determined", "in", "six", "patients", "with", "C0524909#ent", "<e2>", "in", "ten", "healthy", "control", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [25, 26]}}
{"token": ["Caspase-2", "processing", "does", "not", "occur", "in", "thymocytes", "lacking", "Apaf-1", "or", "C1705066#ent", "<e1>", ",", "suggesting", "that", "in", "this", "cell", "type", "activation", "of", "C1453171#ent", "<e2>", "occurs", "downstream", "of", "apoptosome", "formation"], "h": {"id": "C1705066", "name": "C1705066#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1453171", "name": "C1453171#ent", "pos": [21, 22]}}
{"token": ["From", "these", "data", "we", "conclude", "that", "AT(1)-derived", "signaling", "molecules", ",", "specifically", "C0001477#ent", "<e1>", "PKCdelta", ",", "participate", "in", "AngII-induced", "C1527617#ent", "<e2>", "activation", "through", "PYK2", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1527617", "name": "C1527617#ent", "pos": [18, 19]}}
{"token": ["To", "define", "the", "domains", "of", "C4255227#ent", "<e1>", "determine", "cytoplasmic", "localization", "comparisons", "were", "made", "with", "C1565215#ent", "<e2>", ",", "which", "is", "predominantly", "nuclear", "."], "h": {"id": "C4255227", "name": "C4255227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1565215", "name": "C1565215#ent", "pos": [14, 15]}}
{"token": ["Between", "March", "and", "May", "1996", ",", "the", "patient", "was", "admitted", "several", "times", "to", "a", "neurology", "clinic", "where", "C0026896#ent", "<e1>", "diagnosed", "and", "treatment", "with", "pyridostigmine", "and", "C0010592#ent", "<e2>", "was", "initiated", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [25, 26]}}
{"token": ["Four", "patients", "with", "facial", "dystonia", "C0005747#ent", "<e1>", "and", "oromandibular", "dystonia", "seven", "with", "spasmodic", "torticollis", "and", "four", "with", "C0154676#ent", "<e2>", "observed", "."], "h": {"id": "C0005747", "name": "C0005747#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0154676", "name": "C0154676#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", "to", "C1335238#ent", "<e1>", ",", "wild-type", "PPARalpha", "failed", "to", "recruit", "the", "C1336779#ent", "<e2>", "SMRT", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336779", "name": "C1336779#ent", "pos": [12, 13]}}
{"token": ["Kinetic", "studies", "that", "C0949661#ent", "<e1>", "tightly", "bound", "to", "skeletal", "F-actin", "in", "the", "presence", "of", "C1705556#ent", "<e2>", "."], "h": {"id": "C0949661", "name": "C0949661#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [14, 15]}}
{"token": ["The", "mean", "number", "of", "remaining", "sound", "teeth", "C0011334#ent", "<e1>", "root", "remnants", "the", "elderly", "with", "maxillary", "and", "C0236000#ent", "<e2>", "natural", "teeth", "decreased", "with", "increasing", "age", "."], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0236000", "name": "C0236000#ent", "pos": [16, 17]}}
{"token": ["We", "apply", "the", "model", "to", "data", "from", "the", "Signal-Tandmobiel", "dental", "study", "and", ",", "in", "particular", ",", "to", "four", "binary", "responses", "refer", "to", "C0011334#ent", "<e1>", "experience", "in", "the", "C0236000#ent", "<e2>", "and", "maxillary", "left", "right", "molars"], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0236000", "name": "C0236000#ent", "pos": [27, 28]}}
{"token": ["It", "is", "well", "established", "that", "glucose", "induces", "degradation", "of", "C1709143#ent", "<e1>", ",", "but", "the", "fate", "of", "its", "paralogue", "C1704805#ent", "<e2>", "has", "been", "less", "clear", "."], "h": {"id": "C1709143", "name": "C1709143#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704805", "name": "C1704805#ent", "pos": [18, 19]}}
{"token": ["Time", "course", "viability", "studies", "microscopy", "showed", "dose-dependent", "anti-H.", "pylori", "effects", "with", "undiluted", "C0432255#ent", "<e1>", ",", "GP", ",", "allicin", ",", "and", "C0057695#ent", "<e2>", "a", "lag", "phase", "of", "ca", "."], "h": {"id": "C0432255", "name": "C0432255#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0057695", "name": "C0057695#ent", "pos": [20, 21]}}
{"token": ["The", "C1419619#ent", "<e1>", "values", "of", "oxybutynin", "hydrochloride", "C1452072#ent", "<e2>", ")", "and", "atropine", "sulfate", "monohydrate", "atropine", ")", "were", "nearly", "the", "same", "in", "all", "the", "tissues", "tested", "."], "h": {"id": "C1419619", "name": "C1419619#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1452072", "name": "C1452072#ent", "pos": [7, 8]}}
{"token": ["These", "genes", "encode", "for", "three", "transcription", "factors", "three", "enzymes", ",", "including", "dopamine", "beta", "hydroxylase", "C0669368#ent", "<e1>", "two", "receptors", ",", "including", "the", "C1418938#ent", "<e2>", "and", "the", "estrogen", "alpha", "receptor", "and", "one", "neuropeptide", ",", "oxytocin", "."], "h": {"id": "C0669368", "name": "C0669368#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [21, 22]}}
{"token": ["Pancreatic", "cancer", "cell", "lines", "overexpress", "epidermal", "growth", "factor", "EGF", ")", "receptors", "and", "also", "have", "the", "capacity", "to", "produce", "C1336620#ent", "<e1>", "TGF", "alpha", ",", "the", "alternate", "C0243192#ent", "<e2>", "of", "the", "EGF", "receptor"], "h": {"id": "C1336620", "name": "C1336620#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [25, 26]}}
{"token": ["In", "inducing", "c-jun", ",", "which", "works", "coordinately", "with", "c-fos", "in", "C1710463#ent", "<e1>", "the", "effect", "of", "C1333673#ent", "<e2>", "was", "additive", "with", "that", "of", "IGF-I", "and", "synergistic", "with", "that", "of", "serum", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [15, 16]}}
{"token": ["C0011606#ent", "<e1>", "can", "be", "caused", "by", "a", "variety", "of", "underlying", "C0037274#ent", "<e2>", ",", "infections", ",", "and", "systemic", "diseases"], "h": {"id": "C0011606", "name": "C0011606#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [10, 11]}}
{"token": ["We", "found", "an", "elevated", "percentage", "of", "C1413244#ent", "<e1>", "of", "large", "granular", "lymphocytes", "C0024054#ent", "<e2>", ")", "(", "30", "-", "35", "%", "HNK-I-positive", "cells", ")", "compared", "to", "PBL", "from", "healthy", "matched", "individuals", "."], "h": {"id": "C1413244", "name": "C1413244#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024054", "name": "C0024054#ent", "pos": [12, 13]}}
{"token": ["Importantly", ",", "chromatin", "immunoprecipitation", "the", "selective", "presence", "of", "the", "methyl-CpG-binding", "transcriptional", "repressor", "C1417098#ent", "<e1>", "at", "the", "C1968833#ent", "<e2>", "promoter", "in", "endothelial", "cells"], "h": {"id": "C1417098", "name": "C1417098#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [16, 17]}}
{"token": ["The", "relation", "between", "concentration", "of", "C0700563#ent", "<e1>", "base", "in", "matrix", "and", "epidermal", "flux", "concentration", "of", "C0013227#ent", "<e2>", "in", "matrix", ",", "and", "epidermal", "adsorption", "of", "C0700563#ent", "<e1>", "during", "diffusion", "follow", "hyperbolic", "fashion", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0700563", "name": "C0700563#ent", "pos": [5, 6]}}
{"token": ["Signal", "transduction", "binding", "of", "AMF", "to", "its", "receptor", ",", "a", "cell", "surface", "glycoprotein", "78", "kD", "(", "C1332083#ent", "<e1>", ")", ",", "is", "mediated", "by", "a", "C0043167#ent", "<e2>", "G", "protein", "inositol", "phosphate", "production", "and", "the", "phosphorylation", "of", "C1332083#ent", "<e1>", "."], "h": {"id": "C1332083", "name": "C1332083#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [24, 25]}}
{"token": ["Thirty-one", "C0014544#ent", "<e1>", "patients", "with", "seizures", "refractory", "to", "conventional", "anticonvulsants", "were", "treated", "by", "C0009033#ent", "<e2>", "their", "regimen", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009033", "name": "C0009033#ent", "pos": [13, 14]}}
{"token": ["Our", "case", "was", "unique", "because", ",", "like", "C1822619#ent", "<e1>", ",", "the", "tumor", "was", "connected", "to", "the", "epidermis", "and", "C0021933#ent", "<e2>", "downward", "into", "the", "deep", "dermis"], "h": {"id": "C1822619", "name": "C1822619#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021933", "name": "C0021933#ent", "pos": [18, 19]}}
{"token": ["C1416611#ent", "<e1>", "was", "partially", "blocked", "by", "C0724709#ent", "<e2>", "(", "100", "-", "300", "microM", ")", "and", "in", "its", "presence", ",", "hypoxic", "potentiation", "C1416611#ent", "<e1>", "was", "abolished", "."], "h": {"id": "C1416611", "name": "C1416611#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [6, 7]}}
{"token": ["The", "p53", "tumor", "suppressor", "protein", "be", "phosphorylated", "at", "several", "sites", "within", "the", "N-", "and", "C-terminal", "domains", "and", "several", "C0033640#ent", "<e1>", "been", "shown", "to", "phosphorylate", "C1705526#ent", "<e2>", "in", "vitro"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [24, 25]}}
{"token": ["The", "concept", "that", "the", "host", "response", "to", "a", "single", "agent", "evoke", "two", "distinct", "pathologies", "(", "C0023524#ent", "<e1>", "and", "MS", ")", "derives", "from", "a", "C0026918#ent", "<e2>", "peripheral", "nerves-leprosy", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [23, 24]}}
{"token": ["By", "studying", "congeners", "covering", "a", "large", "range", "of", "C0033223#ent", "<e1>", "physicochemical", "characteristics", ",", "their", "C1539479#ent", "<e2>", "within", "the", "environmental", "and", "the", "factors", "influencing", "biological", "responses", "be", "better", "understood", "."], "h": {"id": "C0033223", "name": "C0033223#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [14, 15]}}
{"token": ["However", ",", "considering", "the", "role", "of", "HES", "proteins", "C1539479#ent", "<e1>", "specification", "of", "cortical", "neurons", ",", "these", "findings", "suggest", "that", "thyroid", "hormone", "and", "C0033223#ent", "<e2>", "exposure", ",", "may", "influence", "C1539479#ent", "<e1>", "specification", "of", "cortical", "neurons", "."], "h": {"id": "C0033223", "name": "C0033223#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [8, 9]}}
{"token": ["The", "presence", "of", "discrete", "cavities", "is", "a", "major", "structural", "difference", "MMOH", ",", "which", "can", "hydroxylate", "C0067320#ent", "<e1>", ",", "and", "toluene/o-xylene", "monooxygenase", "hydroxylase", "(", "C1364142#ent", "<e2>", ")", ",", "which", "can", "not", "."], "h": {"id": "C0067320", "name": "C0067320#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1364142", "name": "C1364142#ent", "pos": [23, 24]}}
{"token": ["C0070570#ent", "<e1>", "itself", ",", "a", "specific", "substrate", "for", "C0038769#ent", "<e2>", "P", "at", "10", "microM", ",", "also", "became", "an", "M", "substrate", "1", "mM", "concentration", "."], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038769", "name": "C0038769#ent", "pos": [8, 9]}}
{"token": ["To", "compare", "the", "C0036557#ent", "<e1>", ",", "anaesthetic-sparing", "and", "arterial", "blood-gas", "of", "two", "medetomidine", "(", "C1413596#ent", "<e2>", ")", "doses", "used", "as", "pre-anaesthetic", "medication", "in", "sheep", "undergoing", "experimental", "orthopaedic", "surgery", "."], "h": {"id": "C0036557", "name": "C0036557#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413596", "name": "C1413596#ent", "pos": [14, 15]}}
{"token": ["Mutations", "in", "the", "von", "Willebrand", "factor", "gene", "for", "C0042974#ent", "<e1>", "in", "particular", "those", "responsible", "for", "C1264039#ent", "<e2>", "are", "being", "increasingly", "identified", "."], "h": {"id": "C0042974", "name": "C0042974#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C1264039", "name": "C1264039#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "like", "cholestyramine", ",", "C0354648#ent", "<e1>", "is", "of", "benefit", "in", "patients", "with", "primary", "hypercholesterolaemia", "associated", "C0020557#ent", "<e2>", "(", "type", "IIa", "hyperlipoproteinaemia", "."], "h": {"id": "C0354648", "name": "C0354648#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "substrate", "or", "substrate", "analog", "binding", "on", "the", "stability", "of", "wild-type", "C2826549#ent", "<e1>", "and", "isovaleryl-CoA", "dehydrogenase", "i3VD", ")", "and", "their", "C0678941#ent", "<e2>", "K304E-", "and", "T168A-MCAD", "and", "A282V-i3VD", ")", "is", "examined", "."], "h": {"id": "C2826549", "name": "C2826549#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0678941", "name": "C0678941#ent", "pos": [22, 23]}}
{"token": ["Prions(proteinaceous", "C0009450#ent", "<e1>", "are", "responsible", "to", "C0162534#ent", "<e2>", "in", "man", "and", "animals", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0162534", "name": "C0162534#ent", "pos": [6, 7]}}
{"token": ["Typical", "childhood", "C0009450#ent", "<e1>", "not", "sufficiently", "C0162534#ent", "<e2>", "for", "their", "asymptotic", "dynamics", "to", "be", "likely", "to", "exhibit", "such", "behaviour", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0162534", "name": "C0162534#ent", "pos": [6, 7]}}
{"token": ["The", "physostigmine", "(", "100", "micrograms/kg", ",", "s.c.)-induced", "antinociceptive", "effect", "was", "totally", "abolished", "by", "C0101767#ent", "<e1>", "treatment", ",", "but", "that", "of", "C0030038#ent", "<e2>", "(", "30", "micrograms/kg", ",", "s.c", ".", ")"], "h": {"id": "C0101767", "name": "C0101767#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030038", "name": "C0030038#ent", "pos": [20, 21]}}
{"token": ["Vinorelbine", "(", "Navelbine", ")", "is", "a", "new", "C0042672#ent", "<e1>", "chemically", "differs", "from", "C0042671#ent", "<e2>", "by", "substitutions", "on", "the", "catharantine", "moiety", "of", "the", "molecule", "."], "h": {"id": "C0042672", "name": "C0042672#ent", "pos": [7, 8]}, "relation": "chemical_structure_of", "t": {"id": "C0042671", "name": "C0042671#ent", "pos": [12, 13]}}
{"token": ["Vinorelbine", "is", "a", "new", "C0042672#ent", "<e1>", "differs", "chemically", "from", "C0042671#ent", "<e2>", "by", "a", "substitution", "of", "the", "catharanthine", "moiety", "."], "h": {"id": "C0042672", "name": "C0042672#ent", "pos": [4, 5]}, "relation": "chemical_structure_of", "t": {"id": "C0042671", "name": "C0042671#ent", "pos": [9, 10]}}
{"token": ["C0031269#ent", "<e1>", "a", "rare", "genetic", "disorder", "by", "mucocutaneous", "melanin", "deposition", ",", "C1257915#ent", "<e2>", "an", "increased", "risk", "of", "cancer", ",", "both", "intestinal", "and", "extra-intestinal", "."], "h": {"id": "C0031269", "name": "C0031269#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1257915", "name": "C1257915#ent", "pos": [11, 12]}}
{"token": ["Remarkable", "features", "of", "the", "present", "case", "are", "the", "histological", "diagnosis", "C0027707#ent", "<e1>", "the", "absence", "of", "C1867047#ent", "<e2>", "as", "well", "as", "a", "possible", "association", "with", "the", "administration", "of", "non-steroidal", "antiinflammatory", "drugs"], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1867047", "name": "C1867047#ent", "pos": [15, 16]}}
{"token": ["The", "biological", "functions", "two", "C1335554#ent", "<e1>", "SHP", "and", "C1870006#ent", "<e2>", ",", "serve", "to", "illustrate", "the", "dichotomy", "by", "which", "this", "class", "of", "enzymes", "regulate", "immune", "responses"], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "the", "receptor-effector", "mechanism", "for", "the", "hypnotic-anesthetic", "action", "of", "dexmedetomidine", "involves", "an", "inhibitory", "C0086376#ent", "<e1>", "and", "increased", "conductance", "through", "a", "C1416548#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416548", "name": "C1416548#ent", "pos": [23, 24]}}
{"token": ["Western", "blot", "analyses", "a", "reduction", "in", "the", "C0086376#ent", "<e1>", "underlying", "Kv4.2", ",", "Kv4.3", ",", "and", "C1416548#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416548", "name": "C1416548#ent", "pos": [15, 16]}}
{"token": ["As", "recently", "described", ",", "BST-1", "is", "a", "glycosyl-phosphatidylinositol", "(GPI)-anchored", "surface", "molecule", "exhibits", "homology", "with", "C2827388#ent", "<e1>", "and", "Aplysia", "C1413221#ent", "<e2>"], "h": {"id": "C2827388", "name": "C2827388#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413221", "name": "C1413221#ent", "pos": [18, 19]}}
{"token": ["A", "far", "migrating", "cationic", "isoperoxidase", "C1414090#ent", "<e1>", "was", "isolated", "from", "the", "medium", "after", "application", "of", "C1705551#ent", "<e2>", ",", "the", "effective", "stimulator", "for", "peroxidase", "secretion", "."], "h": {"id": "C1414090", "name": "C1414090#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705551", "name": "C1705551#ent", "pos": [15, 16]}}
{"token": ["In", "this", "review", ",", "COX-1", "and", "C1565860#ent", "<e1>", "been", "shown", "to", "be", "homologous", "in", "C0175168#ent", "<e2>", "ability", "to", "synthesize", "PG", ",", "but", "they", "have", "been", "also", "shown", "to", "be", "induced", "differently", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [14, 15]}}
{"token": ["By", "using", "cells", "that", "are", "proficient", "or", "deficient", "for", "FANCD2", ",", "ATR", ",", "or", "C0004135#ent", "<e1>", ",", "we", "showed", "that", "C0532362#ent", "<e2>", "induces", "FANCD2", "monoubiquitination", "and", "nuclear", "foci", "formation"], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0532362", "name": "C0532362#ent", "pos": [20, 21]}}
{"token": ["The", "C0017428#ent", "<e1>", "of", "all", "three", "strains", "contain", "9762", "nucleotides", "(", "C1417869#ent", "<e2>", ")", ",", "exclusive", "of", "the", "3", "'", "poly", "A", "tract"], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [11, 12]}}
{"token": ["Group", "1", "of", "20", "eyes", "at", "risk", "to", "the", "development", "of", "C0017605#ent", "<e1>", "had", "been", "treated", "with", "C0031923#ent", "<e2>", "at", "least", "8", "years", "."], "h": {"id": "C0017605", "name": "C0017605#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0031923", "name": "C0031923#ent", "pos": [17, 18]}}
{"token": ["The", "C2926735#ent", "<e1>", "of", "obstructive", "apnea", "the", "most", "significant", "variable", "to", "differentiate", "between", "C0038644#ent", "<e2>", "victims", "and", "control", "infants"], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038644", "name": "C0038644#ent", "pos": [13, 14]}}
{"token": ["The", "in", "vivo", "relevance", "of", "the", "ProteaseSpot", "method", "was", "confirmed", "by", "cleavage", "of", "full-length", "C1364818#ent", "<e1>", "with", "C1314771#ent", "<e2>", "in", "human", "embryonic", "kidney", "293", "cells", "tagged", "C1364818#ent", "<e1>", "."], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "we", "evaluated", "two", "alpha-secretase", "candidates", ",", "a", "disintegrin", "and", "metalloprotease", "(", "C1314771#ent", "<e1>", ")", "10", "and", "ADAM17", "in", "Hup", "A-induced", "non-amyloidogenic", "C1364818#ent", "<e2>", "metabolism", "."], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [23, 24]}}
{"token": ["C0000981#ent", "<e1>", "produced", "a", "modest", "C0041983#ent", "<e2>", "was", "not", "suppressible", "by", "pyrazinamide", "."], "h": {"id": "C0000981", "name": "C0000981#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041983", "name": "C0041983#ent", "pos": [5, 6]}}
{"token": ["In", "the", "two", "C0567085#ent", "<e1>", "carcinogenicity", "studies", "C0063491#ent", "<e2>", "and", "4HE", "increased", "incidences", "of", "uterine", "adenocarcinomas", "multiplicities", "of", "C0567085#ent", "<e1>", "proliferative", "lesions", ",", "E2-treatment", "being", "associated", "with", "tendency", "for", "promotion", "."], "h": {"id": "C0063491", "name": "C0063491#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [3, 4]}}
{"token": ["These", "persulfates", "can", "produce", "a", "variety", "of", "cutaneous", "and", "respiratory", "responses", "including", "allergic", "eczematous", "contact", "dermatitis", "C0162823#ent", "<e1>", "localized", "edema", ",", "generalized", "urticaria", "C0035455#ent", "<e2>", ",", "asthma", ",", "and", "syncope", "."], "h": {"id": "C0162823", "name": "C0162823#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [23, 24]}}
{"token": ["C0699371#ent", "<e1>", ",", "a", "progestogen", "only", "oral", "contraceptive", "C0015117#ent", "<e2>", "mg", ")", ",", "was", "evaluated", "for", "its", "contraceptive", "efficacy", "and", "safety", "in", "425", "women", "aged", "between", "16", "and", "47", "years", "."], "h": {"id": "C0699371", "name": "C0699371#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015117", "name": "C0015117#ent", "pos": [8, 9]}}
{"token": ["A", "28-year-old", ",", "ambitious", ",", "academically", "successful", "Asian", "man", "with", "a", "zeal", "for", "hard", "work", "C0021345#ent", "<e1>", "its", "resultant", "C0023380#ent", "<e2>", "and", "fatigue", "."], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [19, 20]}}
{"token": ["A", "C1263960#ent", "<e1>", ",", "hyperosmolar", "pre-coma", ",", "aggravated", "by", "associated", "C0020437#ent", "<e2>", "."], "h": {"id": "C1263960", "name": "C1263960#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [10, 11]}}
{"token": ["The", "macrolide", "antibiotic", "erythromycin", "EM", ")", "affects", "gastrointestinal", "motor", "activity", "acting", "as", "C0243192#ent", "<e1>", "of", "motilin", "receptors", "on", "the", "smooth", "muscle", "cells", "the", "C0030920#ent", "<e2>"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [23, 24]}}
{"token": ["Therefore", ",", "we", "carried", "out", "the", "present", "investigation", "and", "found", "that", "C3273473#ent", "<e1>", "of", "in", "vitro", "grown", "C1704969#ent", "<e2>", ",", "DU145", "and", "LNCaP", "cells", "generally", "expressed", "a", "granular", "secretion"], "h": {"id": "C3273473", "name": "C3273473#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704969", "name": "C1704969#ent", "pos": [17, 18]}}
{"token": ["In", "a", "previous", "study", ",", "we", "found", "that", "the", "C0034541#ent", "<e1>", "potential", "of", "C0950252#ent", "<e2>", "increased", "with", "prolonged", "air", "exposure"], "h": {"id": "C0034541", "name": "C0034541#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0950252", "name": "C0950252#ent", "pos": [13, 14]}}
{"token": ["Prolonged", "application", "of", "cyclopiazonic", "acid", "a", "C0001645#ent", "<e1>", "of", "the", "endoplasmic", "reticulum", "calcium", "pump", "totally", "abolishes", "the", "C0035983#ent", "<e2>", "action", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035983", "name": "C0035983#ent", "pos": [17, 18]}}
{"token": ["So", ",", "it", "is", "suggested", "that", "C0011685#ent", "<e1>", "inhibits", "the", "sialyltransferase", "activity", "C6", "glioma", "cells", "through", "a", "C0249866#ent", "<e2>"], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0249866", "name": "C0249866#ent", "pos": [17, 18]}}
{"token": ["In", "radioligand", "binding", "to", "C0001614#ent", "<e1>", "A-74283", "had", "high", "affinity", "(", "equipotent", "to", "C0050079#ent", "<e2>", ")", "and", "high", "selectivity", "for", "5HT1A", "receptors", "to", "5HT1B", "sites", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0050079", "name": "C0050079#ent", "pos": [13, 14]}}
{"token": ["In", "FBP-transfected", "NIH/3T3", "(", "FBP-tNIH/3T3", ")", "cells", ",", "which", "internalised", "about", "three", "times", "more", "C2939773#ent", "<e1>", "the", "mock-transfected", "cells", ",", "the", "cytotoxtic", "potential", "of", "C1511896#ent", "<e2>", "showed", "a", "clear", "increase", "."], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1511896", "name": "C1511896#ent", "pos": [24, 25]}}
{"token": ["Both", "proteins", "displayed", "greatest", "affinity", "for", "folic", "acid", "C2939773#ent", "<e1>", ",", "and", "the", "antifolates", "CB3717", "and", "5,10-dideazatetrahydrofolate", "(", "C1511896#ent", "<e2>", ")", "."], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1511896", "name": "C1511896#ent", "pos": [18, 19]}}
{"token": ["C0252902#ent", "<e1>", "1.0", "mol", "of", "phosphate/mol", "of", "40", "S", "ribosomal", "subunits", "C1419699#ent", "<e2>"], "h": {"id": "C0252902", "name": "C0252902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419699", "name": "C1419699#ent", "pos": [11, 12]}}
{"token": ["Possible", "alterations", "in", "spinal", "systems", "containing", "calcitonin", "gene-related", "peptide", "C1704715#ent", "<e1>", ")", "due", "to", "C0162323#ent", "<e2>", "were", "assessed", "in", "rats", "3", "-", "4", "weeks", "after", "an", "intradermal", "injection", "of", "Freund's", "adjuvant", "the", "low", "back"], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162323", "name": "C0162323#ent", "pos": [14, 15]}}
{"token": ["Five", "patients", "with", "C0013595#ent", "<e1>", "showed", "typical", "symptoms", ",", "5", "acute", "C0009952#ent", "<e2>", "patients", "and", "5", "normal", "subjects", "tested", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [11, 12]}}
{"token": ["Using", "mobility", "shift", "assays", "we", "demonstrate", "that", "in", "the", "C0172956#ent", "<e1>", "PMA", "induction", "requires", "the", "binding", "of", "nuclear", "proteins", "the", "C0812380#ent", "<e2>", "well", "as", "to", "the", "adjacent", "AP-1", "element"], "h": {"id": "C0172956", "name": "C0172956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812380", "name": "C0812380#ent", "pos": [20, 21]}}
{"token": ["The", "presentation", "may", "range", "from", "a", "minor", "conjunctivitis", "resulting", "from", "an", "C0041912#ent", "<e1>", "a", "serious", ",", "debilitating", "C0022573#ent", "<e2>"], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022573", "name": "C0022573#ent", "pos": [17, 18]}}
{"token": ["Dichloro-", "and", "C0718099#ent", "<e1>", "DCA", "and", "TCA", ")", "and", "C0008232#ent", "<e2>", "are", "formed", "during", "chlorination", "disinfection", "of", "drinking", "water"], "h": {"id": "C0718099", "name": "C0718099#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008232", "name": "C0008232#ent", "pos": [9, 10]}}
{"token": ["Significant", "reductions", "in", "the", "hypotensive", "effect", "of", "C0028066#ent", "<e1>", "were", "observed", "in", "rats", "subjected", "to", "C0002063#ent", "<e2>", ",", "acidosis", ",", "or", "hypercarbia", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002063", "name": "C0002063#ent", "pos": [15, 16]}}
{"token": ["In", "the", "latter", "assay", "C0062021#ent", "<e1>", "attenuated", "the", "body", "weight", "loss", "altering", "the", "C0013604#ent", "<e2>"], "h": {"id": "C0062021", "name": "C0062021#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [13, 14]}}
{"token": ["This", "work", "shows", "a", "mechanism", "whereby", "O(6)-methylguanine", "adducts", "by", "C0076080#ent", "<e1>", "lead", "to", "inhibition", "of", "C2986464#ent", "<e2>", "illustrates", "a", "link", "between", "mismatch", "repair", "of", "alkylator-induced", "DNA", "damage", "and", "cell", "death"], "h": {"id": "C0076080", "name": "C0076080#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [15, 16]}}
{"token": ["C0235946#ent", "<e1>", "noted", "more", "commonly", "in", "patients", "with", "C0023896#ent", "<e2>"], "h": {"id": "C0235946", "name": "C0235946#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023896", "name": "C0023896#ent", "pos": [8, 9]}}
{"token": ["To", "investigate", "the", "role", "of", "C0017349#ent", "<e1>", "the", "modulation", "of", "gastric", "epithelial", "cell", "apoptosis", "induced", "by", "C0850666#ent", "<e2>"], "h": {"id": "C0017349", "name": "C0017349#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0850666", "name": "C0850666#ent", "pos": [16, 17]}}
{"token": ["In", "clinical", "trials", "patients", "with", "mild", "to", "moderate", "essential", "hypertension", "C0216784#ent", "<e1>", "was", "as", "effective", "as", "losartan", ",", "lisinopril", ",", "C0014027#ent", "<e2>", ",", "amlodipine", "and", "hydrochlorothiazide", "."], "h": {"id": "C0216784", "name": "C0216784#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014027", "name": "C0014027#ent", "pos": [20, 21]}}
{"token": ["C0017337#ent", "<e1>", "that", "were", "differentially", "expressed", "in", "C3890887#ent", "<e2>", "compared", "to", "NDSF", "and", "reverted", "by", "treatment", "with", "antirheumatic", "drugs", "verified", "by", "semiquantitative", "polymerase", "chain", "reaction", "by", "chemiluminescent", "enzyme", "immunoassay"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890887", "name": "C3890887#ent", "pos": [7, 8]}}
{"token": ["The", "functional", "Dendranthema", "CHS", "C0017337#ent", "<e1>", "formed", "three", "well-supported", "subfamilies", ":", "SF1", ",", "C3890887#ent", "<e2>", ",", "and", "SF3", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890887", "name": "C3890887#ent", "pos": [13, 14]}}
{"token": ["This", "chapter", "reports", "the", "combination", "of", "RNA", "arbitrarily", "primed", "polymerase", "chain", "reaction", "RAP-PCR", ")", "and", "cDNA", "array", "defined", "C0017337#ent", "<e1>", "for", "a", "highly", "sensitive", "analysis", "of", "gene", "expression", "in", "C3890887#ent", "<e2>", "using", "small", "amounts", "total", "RNA"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3890887", "name": "C3890887#ent", "pos": [29, 30]}}
{"token": ["Antitachycardia", "pacing", "C1705556#ent", "<e1>", ")", "effectively", "treats", "C0344432#ent", "<e2>", "VT", ")", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0344432", "name": "C0344432#ent", "pos": [7, 8]}}
{"token": ["2", ")", "The", "standard", "treatment", "neuropathic", "pain", "associated", "with", "diabetes", "or", "C0032768#ent", "<e1>", "a", "tricyclic", "antidepressant", "with", "C0060926#ent", "<e2>", "as", "an", "alternative", "."], "h": {"id": "C0032768", "name": "C0032768#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [17, 18]}}
{"token": ["Gabapentin", "(", "C3538683#ent", "<e1>", ")", "is", "a", "gamma-aminobutyric", "acid", "analog", "synthesized", "for", "its", "C0003286#ent", "<e2>", "actions", "."], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "C0015020#ent", "<e1>", "may", "act", "synergistically", "with", "C1334117#ent", "<e2>", "ie", ",", "G-CSF", ")", "to", "protect", "and", "accelerate", "the", "recovery", "of", "hematopoietic", "stem", "cells", "exposed", "to", "high", "doses", "radiation", "."], "h": {"id": "C0015020", "name": "C0015020#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334117", "name": "C1334117#ent", "pos": [8, 9]}}
{"token": ["The", "conclusions", "of", "a", "recent", "study", "of", "C0700458#ent", "<e1>", "(", "Novantrone", ")", "in", "C0026769#ent", "<e2>", "the", "approval", "of", "several", "health", "authorities", "its", "use", "in", "patients", "with", "active", "relapsing-remitting", "secondary", "progressive", "sclerosis", "."], "h": {"id": "C0700458", "name": "C0700458#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [13, 14]}}
{"token": ["C0700458#ent", "<e1>", "is", "an", "antineoplastic", "drug", "recently", "approved", "for", "treatment", "of", "C0026769#ent", "<e2>"], "h": {"id": "C0700458", "name": "C0700458#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [11, 12]}}
{"token": ["Adoptive", "transfer", "HSV-1-specific", "immune", "effector", "cells", "IEC", ")", "within", "24", "h", "of", "C0020641#ent", "<e1>", "of", "virus", "prevents", "C0035333#ent", "<e2>", "."], "h": {"id": "C0020641", "name": "C0020641#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035333", "name": "C0035333#ent", "pos": [17, 18]}}
{"token": ["In", "comparison", "to", "the", "co-expression", "of", "cytochrome", "b", "5", ")", "with", "the", "C0065017#ent", "<e1>", ",", "the", "co-expression", "with", "C1414571#ent", "<e2>", "did", "not", "cause", "any", "differences", "in", "the", "GLA", "level", "."], "h": {"id": "C0065017", "name": "C0065017#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414571", "name": "C1414571#ent", "pos": [18, 19]}}
{"token": ["Similarly", ",", "we", "observed", "2", "patients", "with", "C0149521#ent", "<e1>", "developed", "pancreatic", "cancer", "and", "24", "months", "after", "the", "evidence", "of", "C1537502#ent", "<e2>", "mutations", "in", "pancreatic", "brushings", "."], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [19, 20]}}
{"token": ["The", "risk", "is", "the", "greatest", "in", "patients", "with", "C0035435#ent", "<e1>", "the", "fibrillation", "is", "recent", "and", "when", "underlying", "C0018824#ent", "<e2>", "uncompensated", "."], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [17, 18]}}
{"token": ["Clinical", "and", "genetic", "findings", "suggest", "that", "there", "is", "a", "genetic", "heterogeneity", "of", "C0035435#ent", "<e1>", "as", "a", "whole", "(", "verified", "+", "likely", ")", "and", "verified", "C0035435#ent", "<e1>", "(", "without", "and", "with", "C0018824#ent", "<e1>", "."], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [30, 31]}}
{"token": ["The", "expression", "of", "secreted", "patterning", "molecules", "C1332428#ent", "<e1>", "and", "Wnt7b", ",", "but", "not", "C1335824#ent", "<e2>", "or", "Wnt11", ",", "were", "demonstrated", "by", "RT-PCR", "and", "northern", "blot", "hybridization", "RNA", "from", "the", "RUB1", "cells", "."], "h": {"id": "C1332428", "name": "C1332428#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335824", "name": "C1335824#ent", "pos": [13, 14]}}
{"token": ["RalA", "C1333729#ent", "<e1>", "associates", "with", "a", "C0031671#ent", "<e2>", "PLD", ")", "that", "is", "activated", "in", "v-Src-", "and", "v-Ras-transformed", "cells", "."], "h": {"id": "C1333729", "name": "C1333729#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [6, 7]}}
{"token": ["ELISA", "on", "lung", "homogenates", "showed", "higher", "concentrations", "of", "TNF-alpha", ",", "IL-10", ",", "and", "C1705751#ent", "<e1>", "in", "rats", "treated", "with", "E.", "coli", "C2697656#ent", "<e2>", "compared", "with", "those", "treated", "with", "C2697656#ent", "<e2>", "or", "E.", "coli", "P<0.05", ")", "."], "h": {"id": "C1705751", "name": "C1705751#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [21, 22]}}
{"token": ["Three", "patients", "had", "five", "'", "serious", "adverse", "events", "between", "them", "--", "two", "C0751495#ent", "<e1>", ",", "one", "fall", ",", "one", "C0032290#ent", "<e2>", "one", "gastroenteritis", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0032290", "name": "C0032290#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", "the", "mechanism", "of", "action", "of", "C0034348#ent", "<e1>", "human", "meningioma", "in", "the", "simultaneous", "presence", "of", "C0016755#ent", "<e2>", "L-alanine", "was", "investigated", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016755", "name": "C0016755#ent", "pos": [18, 19]}}
{"token": ["C3", "and", "C1436356#ent", "<e1>", "the", "low-molecular-mass", "GTP-binding", "proteins", "Rho", "and", "C1705328#ent", "<e2>", "."], "h": {"id": "C1436356", "name": "C1436356#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [10, 11]}}
{"token": ["After", "a", "4-week", "single-blind", "placebo", "run-in", ",", "eligible", "patients", "were", "randomised", "to", "receive", "C0248719#ent", "<e1>", "40", "mg", ",", "C0248719#ent", "<e1>", "80", "mg", ",", "C0126174#ent", "<e1>", "50", "mg", ",", "or", "placebo", "."], "h": {"id": "C0248719", "name": "C0248719#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [23, 24]}}
{"token": ["The", "C0751950#ent", "<e1>", "of", "8", "with", "C0026769#ent", "<e2>", "9", "with", "amyotrophic", "lateral", "sclerosis", "8", "with", "Steinert's", "disease", "11", "myopathies", ",", "and", "10", "suffering", "from", "miscellaneous", "neurological", "diseases"], "h": {"id": "C0751950", "name": "C0751950#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [6, 7]}}
{"token": ["Male", "infants", "predominate", "and", "have", "either", "isolated", "genital", "abnormalities", "C0020295#ent", "<e1>", "conditions", ",", "or", "C0033770#ent", "<e2>"], "h": {"id": "C0020295", "name": "C0020295#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0033770", "name": "C0033770#ent", "pos": [14, 15]}}
{"token": ["We", "report", "the", "occurrence", "of", "C0034960#ent", "<e1>", "two", "sisters", ",", "both", "presenting", "with", "acute", "demyelinating", "polyneuropathy", "the", "C0018378#ent", "<e2>"], "h": {"id": "C0034960", "name": "C0034960#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [17, 18]}}
{"token": ["In", "humans", ",", "reduced", "expression", "of", "frataxin", "is", "associated", "with", "C0016719#ent", "<e1>", "a", "recessive", "inherited", "neurodegenerative", "and", "C0018824#ent", "<e2>", "to", "reduced", "life", "expectancy"], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [17, 18]}}
{"token": ["C0016719#ent", "<e1>", "an", "inherited", "neuromuscular", "disorder", "associated", "with", "significant", "C0018824#ent", "<e2>", "requiring", "special", "care", "anaesthesia", "because", "of", "increased", "sensitivity", "to", "muscle", "relaxants"], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [9, 10]}}
{"token": ["C1516119#ent", "<e1>", "inhibited", "the", "kinase", "activity", "both", "C0139905#ent", "<e2>", "and", "B-RAF", "(", "wild", "type", "V600E", "mutant", "."], "h": {"id": "C1516119", "name": "C1516119#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [7, 8]}}
{"token": ["Late-onset", "peripheral", "spondylarthropathies", "characterised", "by", "severe", "disease", "marked", "elevation", "of", "laboratory", "parameters", "of", "inflammation", ",", "C3892044#ent", "<e1>", "involving", "the", "lower", "limbs", "C0013604#ent", "<e2>", "of", "the", "extremities", "."], "h": {"id": "C3892044", "name": "C3892044#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [21, 22]}}
{"token": ["A", "reversed", "phase", "high-performance", "liquid", "chromatography", "procedure", "used", "to", "assay", "for", "this", "C0013227#ent", "<e1>", "and", "its", "metabolite", ",", "C0006388#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006388", "name": "C0006388#ent", "pos": [18, 19]}}
{"token": ["Alternatives", "in", "generalized", "primary", "grand", "mal", "seizures", "phenobarbital", ",", "possible", "also", "C0037567#ent", "<e1>", "and", "phenytoin", ";", "in", "C0014553#ent", "<e2>", "ethosuximide", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0014553", "name": "C0014553#ent", "pos": [17, 18]}}
{"token": ["In", "the", "present", "study", "we", "evaluated", "the", "presence", "of", "C1824670#ent", "<e1>", "in", "normal", "(", "N", "=", "15", ")", "and", "C0277565#ent", "<e2>", "human", "kidneys", "(", "N", "=", "76", ")", "."], "h": {"id": "C1824670", "name": "C1824670#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [19, 20]}}
{"token": ["Number", "of", "mitoses", "and", "nuclear", "pleomorphism", "the", "two", "most", "important", "factors", "in", "predicting", "the", "C1366837#ent", "<e1>", "score", ";", "the", "absence", "of", "C1705324#ent", "<e2>", "and", "nuclear", "pleomorphism", "important", "in", "lymph", "node", "negative", "and", "positive", "tumours", "respectively", "."], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705324", "name": "C1705324#ent", "pos": [21, 22]}}
{"token": ["Sindbis", "virus", "SV", ")", ",", "a", "single-stranded", "positive-sense", "RNA", "virus", "the", "alphavirus", "genus", "C0040361#ent", "<e1>", ",", "results", "in", "lytic", "infection", "most", "vertebrate", "cell", "lines", "but", "persistent", "C2314882#ent", "<e2>", "post-mitotic", "neurons", "."], "h": {"id": "C0040361", "name": "C0040361#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [26, 27]}}
{"token": ["This", "abnormality", "caused", "recurrent", "C0006285#ent", "<e1>", "in", "the", "lung", "with", "the", "main", "C1510475#ent", "<e2>"], "h": {"id": "C0006285", "name": "C0006285#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1510475", "name": "C1510475#ent", "pos": [12, 13]}}
{"token": ["C0073096#ent", "<e1>", "significantly", "and", "dose-dependently", "increased", "the", "doses", "of", "C0001159#ent", "<e2>", "and", "ouabain", "required", "to", "induce", "the", "arrhythmia", "indexes", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001159", "name": "C0001159#ent", "pos": [9, 10]}}
{"token": ["The", "animals", "were", "anesthetized", "with", "C0936073#ent", "<e1>", "immobilized", "with", "C2980068#ent", "<e2>", "and", "artificially", "ventilated", "room", "air"], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2980068", "name": "C2980068#ent", "pos": [9, 10]}}
{"token": ["These", "C3540790#ent", "<e1>", "are", "true", "AChEs", ",", "C0001066#ent", "<e2>", "than", "propionylthiocholine", "and", "butyrylthiocholine", "and", "exhibiting", "excess", "substrate", "inhibition", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001066", "name": "C0001066#ent", "pos": [7, 8]}}
{"token": ["Previous", "results", "in", "terms", "of", "hypertrophy", "and", "survival", ",", "compared", "to", "these", "results", ",", "suggest", "that", "verapamil", "and", "C0041037#ent", "<e1>", "treatments", "reveal", "a", "dissociation", "between", "C0340279#ent", "<e2>", "isomyosin", "distribution", "."], "h": {"id": "C0041037", "name": "C0041037#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0340279", "name": "C0340279#ent", "pos": [25, 26]}}
{"token": ["C0013617#ent", "<e1>", "and", "neostigmine", "are", "C0242896#ent", "<e2>", "commonly", "to", "antagonize", "competitive", "neuromuscular", "block"], "h": {"id": "C0013617", "name": "C0013617#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [5, 6]}}
{"token": ["Currently", ",", "praziquantel", "and", "C3540725#ent", "<e1>", "are", "the", "drug", "of", "choice", "for", "C0036330#ent", "<e2>"], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036330", "name": "C0036330#ent", "pos": [12, 13]}}
{"token": ["C1420222#ent", "<e1>", "(", "xCT", ")", ",", "together", "with", "SLC3A2", "(", "C4084711#ent", "<e2>", ")", ",", "encodes", "the", "heterodimeric", "amino", "acid", "transport", "system", ",", "which", "mediates", "cystine-glutamate", "exchange", "and", "thereby", "regulates", "intracellular", "glutathione", "levels", "."], "h": {"id": "C1420222", "name": "C1420222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4084711", "name": "C4084711#ent", "pos": [10, 11]}}
{"token": ["A", "stock", "solution", "of", "sodium", "salts", "glycochenodeoxycholic", "acid", "GCDC", ")", ",", "taurodeoxycholic", "acid", "TDC", ")", ",", "and", "glycocholic", "acid", "C3537453#ent", "<e1>", ")", ",", "was", "added", "to", "each", "prepared", "sample", "of", "C0541154#ent", "<e2>", "HCl", "."], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0541154", "name": "C0541154#ent", "pos": [30, 31]}}
{"token": ["In", "the", "group", "II", "elimination", "of", "C2347435#ent", "<e1>", "caused", "increase", "in", "RBF", "and", "decrease", "in", "C1417822#ent", "<e2>", "In", "the", "group", "III", "elimination", "of", "C2347435#ent", "<e1>", "influenced", "neither", "RBF", "nor", "renal", "vascular", "resistance", "C1417822#ent", "<e2>", ")", "."], "h": {"id": "C1417822", "name": "C1417822#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [6, 7]}}
{"token": ["Most", "cases", "of", "C1426810#ent", "<e1>", "have", "been", "contracted", "in", "geographic", "regions", "are", "endemic", "for", "C0006035#ent", "<e2>"], "h": {"id": "C1426810", "name": "C1426810#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006035", "name": "C0006035#ent", "pos": [14, 15]}}
{"token": ["The", "poly(ADP-ribose)", "polymer", "C4283882#ent", "<e1>", ")", "is", "mainly", "catabolised", "by", "C1418269#ent", "<e2>"], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418269", "name": "C1418269#ent", "pos": [10, 11]}}
{"token": ["Attention", "is", "given", "to", "opportunities", "for", "therapeutic", "intervention", "small", "molecules", "are", "involved", "in", "C4283882#ent", "<e1>", "signaling", ",", "with", "specific", "focus", "on", "C1418269#ent", "<e2>", "PARG", ")", "and", "AIF", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418269", "name": "C1418269#ent", "pos": [21, 22]}}
{"token": ["By", "the", "method", "of", "isoelectrical", "focussing", "C0031669#ent", "<e1>", "was", "divided", "into", "C1136365#ent", "<e2>", "with", "the", "isoelectrical", "points", "5.33", "+", "/-", "0.02", "and", "4.91", "+", "/-", "0.08", "with", "an", "equal", "specific", "activity", "and", "serological", "specificity"], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [11, 12]}}
{"token": ["The", "most", "frequenly", "involved", "C0029896#ent", "<e1>", "include", "thyrotoxicosis", ",", "hypothyroidism", ",", "the", "auto-immune", "disorders", "thyroid", ",", "C0342443#ent", "<e2>", "Addison", "disease", "acromegaly", ",", "androgen-dependent", "disorders", ",", "hypopituitarism", ",", "hypoparathyroidism", ",", "pseudohypoparathyroidism", "and", "diabetes", "mellitus"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0342443", "name": "C0342443#ent", "pos": [16, 17]}}
{"token": ["Symmetrical", "long", "bone", "pain", "with", "associated", "osteosclerotic", "lesions", ",", "C0221253#ent", "<e1>", "around", "the", "eyelids", ",", "C0339143#ent", "<e2>", ",", "and/or", "diabetes", "insipidus", "ECD", "."], "h": {"id": "C0221253", "name": "C0221253#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [15, 16]}}
{"token": ["C0014175#ent", "<e1>", "appear", "as", "a", "C0030193#ent", "<e2>", "an", "inguinal", "hernia"], "h": {"id": "C0014175", "name": "C0014175#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [5, 6]}}
{"token": ["Endometriosis", "(", "C0014175#ent", "<e1>", ")", "is", "a", "C0030193#ent", "<e2>", "by", "extrauteral", "endometrial", "growths"], "h": {"id": "C0014175", "name": "C0014175#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [7, 8]}}
{"token": ["Of", "special", "interest", "is", "the", "observation", "of", "a", "high", "incidence", "of", "persistent", "C0019163#ent", "<e1>", "antigenemia", "among", "patients", "with", "C0036323#ent", "<e2>", "suggesting", "increased", "susceptibility", "of", "such", "patients", "to", "the", "development", "of", "virus-induced", "chronic", "active", "hepatitis"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [18, 19]}}
{"token": ["A", "major", "C0082608#ent", "<e1>", "human", "plasma", "was", "C1412332#ent", "<e2>", ",", "whereas", "binding", "to", "alpha", "1-acid", "glycoprotein", "relatively", "weak", "and", "concentration", "dependent", "."], "h": {"id": "C0082608", "name": "C0082608#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [7, 8]}}
{"token": ["The", "cardiovascular", "effects", "of", "C0220983#ent", "<e1>", "NaHCO3", ")", "in", "normal", "male", "volunteers", "anesthetized", "with", "C0018549#ent", "<e2>", "were", "measured", "."], "h": {"id": "C0220983", "name": "C0220983#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [14, 15]}}
{"token": ["This", "report", "develops", "typical", "features", "of", "variety", "of", "C0003493#ent", "<e1>", "dissections", ",", "aneurysms", ",", "aortic", "rupture", "C0010054#ent", "<e2>", "arteritis", ",", "aortic", "coarctation", "postoperative", "aorta", "."], "h": {"id": "C0003493", "name": "C0003493#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [16, 17]}}
{"token": ["In", "hypothyroid", "and", "euthyroid", "states", ",", "two", "populations", "of", "C0669372#ent", "<e1>", "were", "seen", ",", "some", "with", "C0065558#ent", "<e2>", "and", "others", "with", "no", "detectable", "message", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0065558", "name": "C0065558#ent", "pos": [16, 17]}}
{"token": ["The", "most", "common", "C0015397#ent", "<e1>", "cataract", ",", "refractive", "error", "presbyopia", ",", "and", "C0029896#ent", "<e2>", "of", "the", "conjunctiva", "and", "sclera", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [12, 13]}}
{"token": ["A", "simple", "definition", "for", "pause", "strength", "C1446659#ent", "<e1>", "has", "been", "given", ",", "quantitatively", "describing", "transcriptional", "pausing", "C0035681#ent", "<e2>"], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [16, 17]}}
{"token": ["These", "data", "suggest", "that", "CF", "does", "not", "alter", "the", "activities", "of", "CYP1A2", ",", "C1705514#ent", "<e1>", ",", "XO", ",", "and", "C3887685#ent", "<e2>", "."], "h": {"id": "C1705514", "name": "C1705514#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [19, 20]}}
{"token": ["longissima", "possesses", "a", "better", "genetic", "system(s", ")", "for", "uptake", "and", "seed", "sequestration", "C1166521#ent", "<e1>", "and", "zinc", ",", "which", "could", "be", "transferred", "to", "C0733440#ent", "<e2>", "durum", "and", "bread", "wheat", "and", "exploited", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0733440", "name": "C0733440#ent", "pos": [22, 23]}}
{"token": ["One", "involves", "partial", "C-terminal", "truncation", "generate", "a", "51", "kDa", "C0034348#ent", "<e1>", "might", "have", "altered", "regulatory", "properties", "the", "other", "involves", "phosphorylation", "and", "C0084913#ent", "<e2>", "targets", "the", "protein", "to", "the", "26S", "proteasome", "complete", "degradation", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0084913", "name": "C0084913#ent", "pos": [21, 22]}}
{"token": ["The", "steroid", "21-hydroxylase", "activity", "of", "C0023899#ent", "<e1>", "microsomes", "decreased", "with", "treatment", "by", "C0282303#ent", "<e2>", "beta-naphthoflavone", "and", "was", "inhibited", "by", "anti-cytochrome", "b5", "immunoglobulin", ",", "although", "that", "of", "adrenocortical", "microsomes", "not", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0282303", "name": "C0282303#ent", "pos": [12, 13]}}
{"token": ["The", "incidence", "of", "C0005424#ent", "<e1>", "investigated", "by", "oral", "cholecystography", "intravenous", "cholangiography", "77", "unselected", "Nigerians", "with", "homozygous", "sickle-cell", "disease", "C0342788#ent", "<e2>", ")", "."], "h": {"id": "C0005424", "name": "C0005424#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0342788", "name": "C0342788#ent", "pos": [18, 19]}}
{"token": ["The", "chromatin", "remodeling", "complex", "SWI/SNF", "exclusively", "contains", "BRG1", "or", "BRM", "as", "an", "C3811804#ent", "<e1>", "but", "the", "physiological", "relevance", "of", "these", "C0001473#ent", "<e2>", "is", "not", "yet", "clear", "."], "h": {"id": "C3811804", "name": "C3811804#ent", "pos": [12, 13]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [20, 21]}}
{"token": ["The", "finding", "of", "different", "C0388638#ent", "<e1>", "activities", "suggested", "that", "different", "C0388638#ent", "<e1>", "C0022173#ent", "<e1>", "exist", "in", "platelets", "as", "reported", "for", "other", "cells", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [12, 13]}}
{"token": ["Differential", "regulation", "COX-2", "expression", "mediated", "through", "C0388638#ent", "<e1>", "C0022173#ent", "<e2>", "was", "comparable", "with", "that", "of", "CoCl(2)-induced", "C0388638#ent", "<e1>", "activity", "in", "these", "two", "C0388638#ent", "<e1>", "C0022173#ent", "<e2>", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [8, 9]}}
{"token": ["The", "cellular", "C0388638#ent", "<e1>", "activity", "and", "mRNA", "levels", "of", "these", "C0388638#ent", "<e1>", "C0022173#ent", "<e1>", "drastically", "changed", "during", "differentiation", "and", "apoptosis", "in", "several", "types", "of", "cells", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [12, 13]}}
{"token": ["ROI", "levels", "in", "zone", "1", "modulated", "using", "N-acetyl-L-cysteine", "(", "C1622105#ent", "<e1>", ")", "as", "a", "ROI", "scavenger", "Rose", "Bengal", "C1705628#ent", "<e2>", ")", "as", "a", "ROI", "generator"], "h": {"id": "C1622105", "name": "C1622105#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [18, 19]}}
{"token": ["C1424306#ent", "<e1>", "is", "a", "C1822659#ent", "<e2>", "in", "the", "dog", "thyroid", "1979", "."], "h": {"id": "C1424306", "name": "C1424306#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1822659", "name": "C1822659#ent", "pos": [4, 5]}}
{"token": ["The", "subjects", "were", "patients", "with", "the", "following", "infections", ":", "2", "of", "intrauterine", "infections", "5", "of", "C0242172#ent", "<e1>", "4", "of", "adnexitis", "and", "2", "of", "C1699561#ent", "<e2>"], "h": {"id": "C0242172", "name": "C0242172#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1699561", "name": "C1699561#ent", "pos": [23, 24]}}
{"token": ["Freshly", "obtained", "C1426677#ent", "<e1>", "contained", "lower", "levels", "of", "C1415652#ent", "<e2>", "than", "did", "fresh", "PM", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [8, 9]}}
{"token": ["Obstructive", "jaundice", "complicates", "pancreatic", "carcinoma", "is", "associated", "with", "complications", "such", "as", "malabsorption", ",", "C0005779#ent", "<e1>", ",", "progressive", "hepatocellular", "dysfunction", "and", "C0267917#ent", "<e2>", "in", "addition", "to", "disabling", "pruritus", ",", "which", "greatly", "interferes", "with", "terminal", "patients", "'", "quality", "of", "life"], "h": {"id": "C0005779", "name": "C0005779#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0267917", "name": "C0267917#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "the", "relationship", "between", "polymorphisms", "in", "the", "first", "exon", "of", "the", "C0812381#ent", "<e1>", "which", "encodes", "for", "C1417054#ent", "<e2>", "MBL", ")", "and", "celiac", "disease"], "h": {"id": "C0812381", "name": "C0812381#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417054", "name": "C1417054#ent", "pos": [17, 18]}}
{"token": ["C1413662#ent", "<e1>", "alone", "or", "given", "in", "conjunction", "with", "C0282210#ent", "<e2>", "stimulation", "decreases", "phosphorylation", "of", "phospholamban", "and", "troponin", "I", "ventricular", "myocytes"], "h": {"id": "C1413662", "name": "C1413662#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [8, 9]}}
{"token": ["Mutagenesis", "of", "cis-elements", "in", "the", "first", "region", "showed", "that", "a", "specific", "C1707135#ent", "<e1>", "-1262", ")", "was", "involved", "in", "C1412637#ent", "<e2>", "transactivation", "and", "a", "nearby", "E-box", "(", "-1248", ")", "was", "also", "implicated", "."], "h": {"id": "C1707135", "name": "C1707135#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412637", "name": "C1412637#ent", "pos": [18, 19]}}
{"token": ["Treatment", "with", "ketogenic", "diets", "using", "medium", "chain", "triglyceride", "C0724624#ent", "<e1>", ")", "oil", "when", "possible", ",", "has", "improved", "C0036572#ent", "<e2>", "the", "5", "patients", "who", "could", "tolerate", "the", "diet", "."], "h": {"id": "C0724624", "name": "C0724624#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [17, 18]}}
{"token": ["Most", "\"", "new", "\"", "C0042769#ent", "<e1>", "such", "as", "the", "C0019104#ent", "<e2>", "result", "from", "environmental", "disruptions", "increase", "human", "contact", "with", "animals", "or", "insect", "vectors", "old", "viruses"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [9, 10]}}
{"token": ["Although", "p38", "alpha", "p38", "beta", "and", "C1705633#ent", "<e1>", "expressed", "in", "keratinocytes", ",", "only", "a", "single", "C0597298#ent", "<e2>", ",", "C1705633#ent", "<e1>", "accounts", "for", "the", "increased", "p38", "activity"], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [15, 16]}}
{"token": ["Platelet-derived", "growth", "factor", "PDGF", ")", "stimulates", "C0031669#ent", "<e1>", "PLC", ")", "activity", "and", "the", "phosphorylation", "of", "the", "C0022173#ent", "<e2>", "PLC", "(", "PLC-gamma", ")", "in", "vitro", "in", "living", "cells"], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [16, 17]}}
{"token": ["To", "test", "the", "hypothesis", "that", "its", "colocalization", "with", "PGHS", "is", "crucial", "for", "C0072259#ent", "<e1>", "we", "determined", "subcellular", "locations", "C1419071#ent", "<e2>", ",", "PGHS-1", ",", "and", "PGHS-2", "in", "bovine", "aortic", "endothelial", "cells", "immunofluorescent", "confocal", "microscopy"], "h": {"id": "C0072259", "name": "C0072259#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419071", "name": "C1419071#ent", "pos": [18, 19]}}
{"token": ["In", "the", "absence", "of", "C1422036#ent", "<e1>", "virions", "or", "of", "viral", "receptors", "coreceptors", "at", "the", "cell", "surface", "C3539699#ent", "<e2>", "was", "incorporated", "in", "intracellular", "vesicles", "but", "not", "detected", "in", "the", "cytosolic", "subcellular", "fraction"], "h": {"id": "C1422036", "name": "C1422036#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [16, 17]}}
{"token": ["The", "data", "from", "recent", "trials", "have", "indicated", "that", "treatment", "of", "patients", "with", "antiplatelet", "drugs", "C0360714#ent", "<e1>", ",", "antihypertensive", "and", "C0935929#ent", "<e2>", "the", "progression", "of", "coronary", "atherosclerosis", "reduces", "cardiovascular", "events", "improves", "prognosis", "of", "coronary", "patients", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [19, 20]}}
{"token": ["In", "a", "prospective", "study", "efficacy", "of", "fiberoptic", "bronchoscopy", "evaluated", "in", "the", "diagnosis", "of", "infections", "with", "opportunistic", "pathogens", "Kaposi's", "sarcoma", "nonspecific", "C1279945#ent", "<e1>", "171", "episodes", "of", "C0032310#ent", "<e2>", "in", "151", "HIV-infected", "patients", "."], "h": {"id": "C1279945", "name": "C1279945#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0032310", "name": "C0032310#ent", "pos": [25, 26]}}
{"token": ["The", "C1413668#ent", "<e1>", "increase", "skin", "permeability", "reversibly", "C2712370#ent", "<e2>", "the", "physicochemical", "nature", "of", "the", "stratum", "corneum", "the", "outer", "most", "layer", "of", "skin", ",", "to", "reduce", "its", "diffusional", "resistance"], "h": {"id": "C1413668", "name": "C1413668#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [7, 8]}}
{"token": ["It", "is", "suggested", "that", "mucosal", "tears", "to", "those", "associated", "with", "C0024633#ent", "<e1>", "added", "to", "the", "differential", "diagnosis", "upper", "GI", "bleeding", "C0426970#ent", "<e2>", "patients", "."], "h": {"id": "C0024633", "name": "C0024633#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0426970", "name": "C0426970#ent", "pos": [20, 21]}}
{"token": ["The", "thymus", "glands", "were", "excised", "for", "therapy", "(", "C0026896#ent", "<e1>", "MG", ")", "or", "experimental", "therapy", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", "were", "compared", "to", "thymic", "biopsies", "patients", "undergoing", "cardiac", "surgery"], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [17, 18]}}
{"token": ["A", "multicenter", ",", "double-blind", ",", "randomized", "trial", "conducted", "to", "assess", "the", "efficacy", ",", "safety", ",", "and", "tolerability", "of", "C0935942#ent", "<e1>", "relative", "to", "amphotericin", "B", "adults", "with", "endoscopically", "documented", "symptomatic", "C0014868#ent", "<e2>"], "h": {"id": "C0935942", "name": "C0935942#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014868", "name": "C0014868#ent", "pos": [29, 30]}}
{"token": ["The", "association", "of", "C0004031#ent", "<e1>", ",", "AFS", ",", "and", "C1837657#ent", "<e2>", "with", "class", "II", "of", "the", "major", "histocompatibility", "complex", "the", "initiation", "of", "these", "inflammatory", "diseases", "the", "context", "of", "antigen", "presentation", "the", "acquired", "immune", "response"], "h": {"id": "C0004031", "name": "C0004031#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1837657", "name": "C1837657#ent", "pos": [9, 10]}}
{"token": ["Lbc", ",", "which", "specifically", "acts", "on", "Rho", "but", "not", "Rac", "or", "Cdc42", ",", "was", "isolated", "as", "a", "C1706553#ent", "<e1>", "is", "composed", "of", "a", "C1832586#ent", "<e2>", "and", "a", "Pleckstrin-homology", "(PH)", "."], "h": {"id": "C1706553", "name": "C1706553#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1832586", "name": "C1832586#ent", "pos": [23, 24]}}
{"token": ["C1447747#ent", "<e1>", "EDL", ")", "is", "a", "new", "member", "of", "the", "C1517488#ent", "<e2>", "high", "sequence", "homology", "with", "lipoprotein", "lipase", "LPL", ")", "."], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [10, 11]}}
{"token": ["In", "conflicting", "period", "experiments", ",", "monkeys", "were", "exposed", "to", "C1414435#ent", "<e1>", "cycles", "(", "C1414435#ent", "<e1>", "11.5:11.5", ")", "and", "24-h", "EF", "cycles", "C0059037#ent", "<e1>", "3:21", ")", "."], "h": {"id": "C1414435", "name": "C1414435#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [21, 22]}}
{"token": ["We", "used", "a", "sensitive", "reverse", "transcription-PCR", "assay", "to", "study", "C0017353#ent", "<e1>", "transcripts", "in", "C0033209#ent", "<e2>", "RAG-deficient", "mice", "."], "h": {"id": "C0017353", "name": "C0017353#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [13, 14]}}
{"token": ["C1704467#ent", "<e1>", "levels", "were", "lower", "in", "C0078956#ent", "<e2>", "than", "in", "B-lineage", "ALL", ",", "which", "could", "be", "ascribed", "to", "simultaneous", "inverse", "relation", "between", "C1704467#ent", "<e1>", "and", "WBC", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [6, 7]}}
{"token": ["Four", "mini-Tn10", "derivatives", "bearing", "the", "C3539710#ent", "<e1>", ",", "cat", ",", "aacC1", "and", "tet", "genes", "with", "C1417081#ent", "<e2>", "of", "the", "pBluescriptII", "plasmid", "were", "constructed", "."], "h": {"id": "C3539710", "name": "C3539710#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417081", "name": "C1417081#ent", "pos": [15, 16]}}
{"token": ["pulses", "of", "different", "doses", "of", "rat", "recLH", "on", "T", "secretion", "adult", "male", "rats", "rendered", "C0271623#ent", "<e1>", "by", "treatment", "with", "the", "GnRH", "antagonist", "C0209366#ent", "<e2>", "."], "h": {"id": "C0271623", "name": "C0271623#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0209366", "name": "C0209366#ent", "pos": [22, 23]}}
{"token": ["Glimepiride", "(", "C0122184#ent", "<e1>", "CAS", "93479", "-", "97", "-", "1", ")", "a", "new", "C0038766#ent", "<e2>", ",", "was", "tested", "in", "acute", ",", "subchronic", "and", "chronic", "toxicity", "studies", "rats", "."], "h": {"id": "C0122184", "name": "C0122184#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [13, 14]}}
{"token": ["We", "show", "in", "the", "present", "study", "that", "C1538842#ent", "<e1>", "interacts", "with", "AR", "and", "binds", "to", "DNA", "and", "C0021345#ent", "<e2>", "."], "h": {"id": "C1538842", "name": "C1538842#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [17, 18]}}
{"token": ["PDGF-BB", "had", "much", "weaker", "effects", "on", "32D/PDGF-beta", "R", "cell", "differentiation", ",", "suggesting", "that", "increased", "C1538842#ent", "<e1>", "expression", "enhanced", "C0021345#ent", "<e2>", "differentiation", "."], "h": {"id": "C1538842", "name": "C1538842#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [18, 19]}}
{"token": ["Unlike", "other", "members", "of", "the", "SNF2", "family", "C1538842#ent", "<e1>", "does", "not", "appear", "to", "form", "large", "protein", "complexes", "in", "vivo", "remodel", "C0021345#ent", "<e2>", "in", "vitro"], "h": {"id": "C1538842", "name": "C1538842#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [20, 21]}}
{"token": ["Myoglobin", "was", "the", "first", "marker", "to", "increase", "in", "blood", "after", "C0340293#ent", "<e1>", "and", "showed", "the", "earliest", "peaks", ",", "whereas", "C0024518#ent", "<e2>", "increased", "latest", "showing", "the", "latest", "peaks", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [19, 20]}}
{"token": ["Clinical", "isolates", "members", "of", "the", "C0085397#ent", "<e1>", "resistance", "to", "drugs", "used", "for", "therapy", "of", "common", "C0005943#ent", "<e2>", "animals", "."], "h": {"id": "C0085397", "name": "C0085397#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [15, 16]}}
{"token": ["Exposure", "to", "C3538757#ent", "<e1>", ",", "KCI", ",", "and", "C1426700#ent", "<e2>", "affected", "the", "entomopathogenic", "nematodes", "Heterorhabditis", "bacteriophora", "Steinernema", "glaseri", "."], "h": {"id": "C3538757", "name": "C3538757#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426700", "name": "C1426700#ent", "pos": [8, 9]}}
{"token": ["C0287990#ent", "<e1>", "processing", "is", "a", "likely", "mechanism", "for", "inactivating", "extracellular", "C1336632#ent", "<e2>"], "h": {"id": "C0287990", "name": "C0287990#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336632", "name": "C1336632#ent", "pos": [10, 11]}}
{"token": ["LY2", "but", "not", "C0070126#ent", "<e1>", "blocked", "the", "LPS-induced", "stabilization", "of", "C1333574#ent", "<e2>", "mRNA", "."], "h": {"id": "C0070126", "name": "C0070126#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [10, 11]}}
{"token": ["Dramatic", "improvements", "in", "tremor", ",", "C0013421#ent", "<e1>", ",", "bradykinesia", ",", "and", "C0085623#ent", "<e2>", "were", "noted", "within", "seconds", "of", "stimulator", "activation", "were", "also", "objectively", "measured", "using", "a", "computerized", "data", "glove", "."], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085623", "name": "C0085623#ent", "pos": [11, 12]}}
{"token": ["Neuroleptic", "drugs", "antipsychotics", ")", "produce", "numerous", "side", "effects", "include", "serious", "extrapyramidal", "symptoms", "of", "akathisia", ",", "C0013421#ent", "<e1>", ",", "neuroleptic", "malignant", "syndrome", "parkinsonian", "reactions", "such", "as", "postural", "abnormality", "tremor", ",", "C0085623#ent", "<e2>", "or", "bradykinesia", ",", "rigidity", ",", "and", "tardive", "dyskinesia"], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085623", "name": "C0085623#ent", "pos": [29, 30]}}
{"token": ["It", "inhibits", "lipid", "peroxidation", "C1565860#ent", "<e1>", "(", "COX-2", ")", "expression", "and", "induces", "C1415329#ent", "<e2>", "GST", ")", "enzymes", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415329", "name": "C1415329#ent", "pos": [12, 13]}}
{"token": ["However", ",", "SUL", "was", "about", "50", "times", "more", "potent", "than", "C1822773#ent", "<e1>", "and", "about", "equipotent", "to", "C0720810#ent", "<e2>", ",", "at", "2", "h", "after", "drug", "administration", "the", "lateral", "ventricle"], "h": {"id": "C1822773", "name": "C1822773#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0720810", "name": "C0720810#ent", "pos": [16, 17]}}
{"token": ["Compared", "with", "gram-positive", "bacteria", "C0085423#ent", "<e1>", "which", "are", "typically", "detected", "in", "the", "periodontal", "pockets", "in", "C0001342#ent", "<e2>", ",", "elicit", "a", "stronger", "antibacterial", "peptide", "response", "of", "hBD-2", "by", "epithelial", "cells"], "h": {"id": "C0085423", "name": "C0085423#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001342", "name": "C0001342#ent", "pos": [15, 16]}}
{"token": ["The", "human", "C0008381#ent", "<e1>", "encoding", "the", "C1413855#ent", "<e2>", "has", "been", "previously", "assigned", "by", "in", "situ", "hybridization", "15q23-q24", "region", "."], "h": {"id": "C0008381", "name": "C0008381#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413855", "name": "C1413855#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "the", "use", "of", "C0066105#ent", "<e1>", "studied", "with", "regard", "to", "postoperative", "asymptomatic", "bacteriuria", "and", "C0042029#ent", "<e2>"], "h": {"id": "C0066105", "name": "C0066105#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "whether", "C0066105#ent", "<e1>", "MH", ")", "or", "cranberry", "tablets", "urinary", "tract", "infections", "C0042029#ent", "<e2>", ")", "in", "people", "with", "neuropathic", "bladder", "spinal", "cord", "injury", "SCI", ")", "."], "h": {"id": "C0066105", "name": "C0066105#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "whether", "C0066105#ent", "<e1>", "MH", ")", "or", "cranberry", "tablets", "C0042029#ent", "<e2>", "UTI", ")", "in", "people", "with", "neuropathic", "bladder", "spinal", "cord", "injury", "SCI", ")", "."], "h": {"id": "C0066105", "name": "C0066105#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [10, 11]}}
{"token": ["In", "other", "cells", "Rb+", "is", "taken", "up", "by", "a", "C0018437#ent", "<e1>", "that", "is", "sensitive", "to", "C0165132#ent", "<e2>", ",", "SCH28080", ",", "omeprazole", ",", "and", "N-ethylmaleimide", "(", "NEM", ")", "."], "h": {"id": "C0018437", "name": "C0018437#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0165132", "name": "C0165132#ent", "pos": [15, 16]}}
{"token": ["Intravenous", "immunoglobulin", "G", "IVIG", ")", "preparations", "are", "used", "in", "several", "disorders", ":", "primary", "and", "secondary", "immunodeficiencies", "autoimmune", "and", "C0242172#ent", "<e1>", "and", "in", "C0009450#ent", "<e2>", "effective", "therapy", "."], "h": {"id": "C0242172", "name": "C0242172#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [22, 23]}}
{"token": ["Fifteen", "patients", "with", "the", "loin", "pain", "C0018965#ent", "<e1>", "LPH", ")", "were", "compared", "with", "10", "patients", "with", "complicated", "C0022658#ent", "<e2>", "to", "the", "same", "tertiary", "centre", "matched", "for", "age", ",", "sex", "and", "duration", "of", "illness"], "h": {"id": "C0018965", "name": "C0018965#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [17, 18]}}
{"token": ["In", "EH", "with", "higher", "arterial", "pressure", "the", "elevation", "of", "C2348358#ent", "<e1>", "accompanied", "by", "a", "normal", "C0043459#ent", "<e2>", "without", "compensatory", "vasodilation", ",", "and", "hence", "TPR", "rose", "to", "exacerbate", "the", "hypertension", "."], "h": {"id": "C2348358", "name": "C2348358#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [15, 16]}}
{"token": ["The", "src", "family", "kinase-selective", "inhibitor", "C1418858#ent", "<e1>", "reduced", "carbachol-stimulated", "tyrosine", "phosphorylation", "of", "FAK", ",", "C1366459#ent", "<e2>", ",", "and", "paxillin", "by", "50", "to", "75", "%", "."], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366459", "name": "C1366459#ent", "pos": [14, 15]}}
{"token": ["These", "results", "identify", "C1337091#ent", "<e1>", "critical", "factor", "the", "suppression", "of", "initiation", "of", "lytic", "C0149678#ent", "<e2>", "infection", "."], "h": {"id": "C1337091", "name": "C1337091#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [13, 14]}}
{"token": ["The", "C2987155#ent", "<e1>", "cascade", "and", "intracellular", "C0001477#ent", "<e2>", "were", "involved", "as", "U73122", "and", "thapsigargin", "inhibited", "RB-induced", "C0001477#ent", "<e2>", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [6, 7]}}
{"token": ["Likewise", ",", "contribution", "of", "the", "corresponding", "signaling", "pathways", "SRIF-induced", "GH", "release", "was", "evaluated", "by", "blocking", "AC", ",", "C2987155#ent", "<e1>", ",", "extracellular", "Ca(2", "+", ")", "influx", ",", "or", "intracellular", "C0001477#ent", "<e2>", "mobilization", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [28, 29]}}
{"token": ["To", "describe", "the", "use", "of", "intrapleural", "instillation", "of", "C0016018#ent", "<e1>", "adjunctive", "therapy", "children", "with", "complicated", "pleural", "effusions", "C0014013#ent", "<e2>", "."], "h": {"id": "C0016018", "name": "C0016018#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014013", "name": "C0014013#ent", "pos": [17, 18]}}
{"token": ["Guidelines", "for", "investigating", "C0002871#ent", "<e1>", "due", "to", "C0002888#ent", "<e2>", "or", "haemoglobinopathy", "are", "well", "established", ",", "whereas", "disturbances", "of", "iron", "metabolism", "often", "difficult", "to", "classify", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0002888", "name": "C0002888#ent", "pos": [7, 8]}}
{"token": ["C0030486#ent", "<e1>", "induced", "by", "C0796160#ent", "<e2>", "19", "-", "6", "MuLV", "could", "be", "attributed", "to", "meningeal", "B-lymphoma"], "h": {"id": "C0030486", "name": "C0030486#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0796160", "name": "C0796160#ent", "pos": [4, 5]}}
{"token": ["Notably", ",", "our", "genetic", "analyses", "that", "Rac1", "activates", "C0063555#ent", "<e1>", ",", "whereas", "NoxR", "and", "C1366537#ent", "<e2>", "may", "function", "together", "in", "a", "parallel", "pathway", "regulates", "Nox", "localization"], "h": {"id": "C0063555", "name": "C0063555#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366537", "name": "C1366537#ent", "pos": [14, 15]}}
{"token": ["Importantly", ",", "a", "strong", "correlation", "between", "Cdc25A", "C0221406#ent", "<e1>", "and", "C0244988#ent", "<e2>", "inactivation", "was", "observed", "in", "human", "tumor", "tissues", "indicating", "that", "C0244988#ent", "<e2>", "inactivation", "may", "account", "for", "Cdc25A", "C0221406#ent", "<e1>", "in", "a", "subset", "of", "human", "tumors"], "h": {"id": "C0244988", "name": "C0244988#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [7, 8]}}
{"token": ["Two", "of", "the", "new", "anticancer", "drugs", "synthesized", "in", "our", "laboratory", "from", "conjugation", "of", "ara-C2", "and", "several", "C3540726#ent", "<e1>", "linked", "through", "a", "C0031640#ent", "<e2>", "prednisolone-", "(", "I", ")", "and", "prednisone-p-ara-C", "(", "II", ")", "."], "h": {"id": "C3540726", "name": "C3540726#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [21, 22]}}
{"token": ["Compared", "to", "C0669372#ent", "<e1>", "from", "human", "and", "dog", ",", "fish", "C0669372#ent", "<e1>", "seemed", "to", "be", "more", "susceptible", "to", "the", "peroxisome", "proliferators", "C0524684#ent", "<e1>", ")", "CF", "and", "FF", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0524684", "name": "C0524684#ent", "pos": [21, 22]}}
{"token": ["In", "conclusion", ",", "we", "report", "a", "direct", "interaction", "between", "C1418985#ent", "<e1>", "and", "subunits", "of", "the", "20S", "catalytic", "particle", "the", "C0286330#ent", "<e2>", "further", "establishing", "the", "involvement", "of", "proteasomal", "degradation", "the", "regulation", "of", "C1418985#ent", "<e1>", "turnover", "."], "h": {"id": "C0286330", "name": "C0286330#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418985", "name": "C1418985#ent", "pos": [9, 10]}}
{"token": ["In", "higher", "doses", ",", "NPY", "caused", "a", "pressor", "effect", "per", "se", ",", "which", "was", "dose-dependently", "antagonized", "by", "C0028066#ent", "<e1>", "but", "not", "by", "C2936568#ent", "<e2>"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2936568", "name": "C2936568#ent", "pos": [22, 23]}}
{"token": ["C3536869#ent", "<e1>", "(GAG)-containing", "proteoglycans", "are", "associated", "with", "C0029134#ent", "<e2>", "plaques", "and", "cerebrovascular", "beta-amyloid", "deposits", "Alzheimer's", "disease", "well", "as", "with", "the", "amyloid", "deposits", "prion", "and", "other", "disorders", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029134", "name": "C0029134#ent", "pos": [7, 8]}}
{"token": ["C0120726#ent", "<e1>", "(", "HF", ")", "is", "a", "C0003374#ent", "<e2>", "to", "cause", "cardiac", "arrhythmias", "susceptible", "patients", "."], "h": {"id": "C0120726", "name": "C0120726#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [7, 8]}}
{"token": ["The", "intestinal", "lymphatic", "transport", "C0120726#ent", "<e1>", ",", "an", "important", ",", "highly", "C0003374#ent", "<e2>", "has", "been", "studied", "in", "a", "conscious", "rat", "model", "after", "oral", "administration"], "h": {"id": "C0120726", "name": "C0120726#ent", "pos": [4, 5]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "different", "representatives", "of", "the", "group", "of", "peptaibiotics", ",", "C0054314#ent", "<e1>", "secondary", "metabolites", "of", "filamentous", "fungi", "on", "C3486724#ent", "<e2>", "larvae", "was", "studied", "."], "h": {"id": "C0054314", "name": "C0054314#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3486724", "name": "C3486724#ent", "pos": [19, 20]}}
{"token": ["Adenoviruses", "(", "AdV", ")", ",", "causing", "fatal", "disseminated", "infections", "bone", "marrow", "transplant", "BMT", ")", "recipients", ",", "are", "associated", "not", "with", "hemorrhagic", "cystitis", "HC", ")", "but", "also", "with", "C0019158#ent", "<e1>", ",", "conjunctivitis", ",", "and", "C0206061#ent", "<e2>"], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [33, 34]}}
{"token": ["Multifocal", "granulomatous", "encephalitis", ",", "C0019158#ent", "<e1>", ",", "nephritis", ",", "myocarditis", ",", "myositis", ",", "and", "C0206061#ent", "<e2>", "found", "in", "all", "3", "kittens", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [14, 15]}}
{"token": ["The", "results", "of", "study", "show", "that", "the", "accent", "is", "on", "the", "prevention", ",", "early", "diagnosis", "early", "therapy", "C0029896#ent", "<e1>", "which", "lead", "to", "C1705280#ent", "<e2>", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [22, 23]}}
{"token": ["A", "22-year-old", "woman", "with", "mitochondriopathy", "and", "pre-existing", "epilepsy", "developed", "C0038220#ent", "<e1>", "SE", ")", "not", "responding", "to", "benzodiazepines", ",", "C0031507#ent", "<e2>", ",", "thiopental", ",", "and", "propofol", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [18, 19]}}
{"token": ["1", "The", "relationship", "between", "mechanical", "fragility", "C0763282#ent", "<e1>", "inhibition", "and", "Heinz", "body", "formation", "in", "erythrocytes", "exposed", "to", "C0013227#ent", "<e2>", "in", "vitro", "has", "been", "investigated", "."], "h": {"id": "C0763282", "name": "C0763282#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["The", "G(M1)-ELISA", "showed", "that", "the", "plant-derived", "C1418397#ent", "<e1>", "bound", "specifically", "to", "C0085131#ent", "<e2>", "suggesting", "that", "it", "retained", "its", "native", "pentameric", "form", "."], "h": {"id": "C1418397", "name": "C1418397#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085131", "name": "C0085131#ent", "pos": [11, 12]}}
{"token": ["After", "renaturation", ",", "both", "recombinant", "proteins", "C1418397#ent", "<e1>", "antigenicity", "and", "the", "ability", "to", "bind", "to", "C0085131#ent", "<e2>", "as", "shown", "by", "in", "vitro", "analysis"], "h": {"id": "C1418397", "name": "C1418397#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085131", "name": "C0085131#ent", "pos": [15, 16]}}
{"token": ["The", "synthetic", "C1418397#ent", "<e1>", "produced", "only", "in", "the", "rice", "endosperm", "strong", "affinity", "for", "C0085131#ent", "<e2>", ",", "thereby", "suggesting", "that", "the", "CTB", "subunits", "formed", "an", "active", "pentamer", "."], "h": {"id": "C1418397", "name": "C1418397#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085131", "name": "C0085131#ent", "pos": [13, 14]}}
{"token": ["In", "their", "early", "'", "teens", "both", "boys", "developed", "C0152025#ent", "<e1>", "with", "sensory", ",", "motor", "and", "autonomic", "components", "C0030567#ent", "<e2>", ",", "and", "signs", "of", "both", "dorsal", "column", "pyramidal", "tract", "damage", "."], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [17, 18]}}
{"token": ["A", "man", ",", "age", "50", ",", "fell", "ill", "with", "C0152025#ent", "<e1>", "followed", "by", "C0030567#ent", "<e2>", "and", "organic", "psychosis", "died", "in", "a", "shock", "6", "weeks", "later", "."], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "provide", "further", "evidence", "of", "a", "link", "between", "ACEI-induced", "cough", "and", "I/D", "polymorphism", "of", "the", "ACE", "gene", "suggest", "that", "ACEIs", "induce", "C0010200#ent", "<e1>", "by", "modulating", "the", "tissue", "level", "of", "C1537501#ent", "<e2>", "."], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [30, 31]}}
{"token": ["The", "data", "presented", "indicate", "that", "C0041296#ent", "<e1>", "in", "Klenovnik", "hospital", "was", "in", "most", "cases", "treated", "with", "C0546863#ent", "<e2>", ",", "the", "combination", "of", "isoniazid", "with", "pyridoxine", ",", "and", "rifampin", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0546863", "name": "C0546863#ent", "pos": [16, 17]}}
{"token": ["Ionic", "detergents", "as", "deoxycholate", "and", "C0037556#ent", "<e1>", "all", "the", "C0949966#ent", "<e2>", "including", "tubulin", "."], "h": {"id": "C0037556", "name": "C0037556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0949966", "name": "C0949966#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "the", "observed", "competition", "between", "FAC1", "and", "Nrf2", "for", "binding", "C1427969#ent", "<e1>", "indicates", "that", "the", "interplay", "between", "these", "three", "C0086376#ent", "<e2>", "has", "important", "implications", "for", "neuronal", "response", "oxidative", "stress"], "h": {"id": "C1427969", "name": "C1427969#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [20, 21]}}
{"token": ["We", "studied", "whether", "the", "PCSK9", "gene", "linked", "to", "the", "risk", "of", "C0948008#ent", "<e1>", "IS", ")", "and", "with", "the", "development", "of", "C0004153#ent", "<e2>"], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [20, 21]}}
{"token": ["The", "most", "common", "cause", "of", "C0948008#ent", "<e1>", "the", "elderly", "is", "C0004153#ent", "<e2>", "."], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [10, 11]}}
{"token": ["Mycobacterium", "ulcerans", "infection", "C0085568#ent", "<e1>", "by", "a", "papule", ",", "nodule", ",", "blotch", "or", "C0013604#ent", "<e2>", "and", "develops", "into", "ulceration", "with", "complications", "which", "can", "lead", "to", "disabilities", "."], "h": {"id": "C0085568", "name": "C0085568#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [13, 14]}}
{"token": ["C0085568#ent", "<e1>", "Buruli", "ulcer", "by", "a", "papule", ",", "nodule", ",", "blotch", "or", "C0013604#ent", "<e2>", "and", "develops", "into", "ulceration", "with", "complications", "which", "can", "lead", "to", "disabilities", "."], "h": {"id": "C0085568", "name": "C0085568#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [12, 13]}}
{"token": ["The", "authors", "evaluated", "the", "systemic", "and", "ocular", "hypotensive", "effects", "of", "C0770150#ent", "<e1>", "Perdipine", ":", "NH", ")", "in", "31", "cases", "with", "C0020538#ent", "<e2>", "over", "160/95", "mmHg", ")", "during", "cataract", "surgery"], "h": {"id": "C0770150", "name": "C0770150#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [20, 21]}}
{"token": ["Human", "eosinophils", "two", "C0035542#ent", "<e1>", "eosinophil", "cationic", "protein", "ECP", ")", "and", "C0059409#ent", "<e2>", "EDN", ")", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059409", "name": "C0059409#ent", "pos": [11, 12]}}
{"token": ["It", "is", "referred", "to", "as", "RNase", "4", "based", "on", "the", "nomenclature", "currently", "used", "for", "the", "genes", "of", "pancreatic", "RNase", "C0035542#ent", "<e1>", "and", "the", "C0059409#ent", "<e2>", "RNase", "2", "RNase", "3", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0059409", "name": "C0059409#ent", "pos": [23, 24]}}
{"token": ["As", "a", "result", ",", "C1334470#ent", "<e1>", "inhibits", "TGF-beta-mediated", "downregulation", "of", "C1705628#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C1334470", "name": "C1334470#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [10, 11]}}
{"token": ["We", "present", "the", "use", "of", "recombinant", "C0015505#ent", "<e1>", "rFVIIa", ")", "in", "a", "patient", "with", "C0079504#ent", "<e2>", "underwent", "total", "thyroidectomy", "of", "a", "large", "richly", "vascularized", "nodule", "(", "10", "cm", ")", "compressing", "the", "trachea", "."], "h": {"id": "C0015505", "name": "C0015505#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079504", "name": "C0079504#ent", "pos": [14, 15]}}
{"token": ["C0294794#ent", "<e1>", ",", "a", "recently", "developed", "C3536756#ent", "<e2>", "ChEI", ")", ",", "has", "been", "reported", "to", "reduce", "APP", "levels", "in", "vitro", "in", "vivo"], "h": {"id": "C0294794", "name": "C0294794#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536756", "name": "C3536756#ent", "pos": [6, 7]}}
{"token": ["These", "results", "show", "that", "Tbc1d1", "regulates", "C2982484#ent", "<e1>", "translocation", "through", "its", "C2984552#ent", "<e2>", "activity", ",", "and", "is", "a", "likely", "Akt", "substrate", "."], "h": {"id": "C2982484", "name": "C2982484#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2984552", "name": "C2984552#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "have", "used", "synthetic", "peptides", "from", "a", "putative", "glycogen", "synthase", "kinase-3", "site", "the", "Drosophila", "translation", "initiation", "factor", "eIF2B", "epsilon", "investigate", "the", "efficacy", "of", "residues", "other", "than", "Ser(P", ")", "as", "priming", "residues", "for", "C0017932#ent", "<e1>", "and", "its", "C1309483#ent", "<e2>", "."], "h": {"id": "C0017932", "name": "C0017932#ent", "pos": [33, 34]}, "relation": "NA", "t": {"id": "C1309483", "name": "C1309483#ent", "pos": [37, 38]}}
{"token": ["Retraction", "was", "rescued", "by", "co-treatment", "with", "the", "S1P3/S1P5", "pathway", "antagonist", ",", "C0038880#ent", "<e1>", ",", "and", "was", "associated", "with", "C1333200#ent", "<e2>"], "h": {"id": "C0038880", "name": "C0038880#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333200", "name": "C1333200#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "protective", "effect", "C4055175#ent", "<e1>", "in", "a", "lipopolysaccharide", "(LPS)-induced", "C0010927#ent", "<e2>", "model", "in", "rats", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [15, 16]}}
{"token": ["These", "results", "reveal", "the", "therapeutic", "potential", "of", "C4055175#ent", "<e1>", "in", "infection-related", "coagulopathy", "of", "C0010927#ent", "<e2>", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [13, 14]}}
{"token": ["C3536873#ent", "<e1>", "IgG", ")", "anti-dsDNA", "antibodies", "commonly", "present", "in", "C0024131#ent", "<e2>", "patients", "and", "several", "autoimmune", "disease-prone", "murine", "strains", "."], "h": {"id": "C3536873", "name": "C3536873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024131", "name": "C0024131#ent", "pos": [9, 10]}}
{"token": ["Instenon", "forte", ",", "a", "combination", "of", "C0019471#ent", "<e1>", ",", "etamivan", "and", "etofylline", "for", "treatment", "of", "C0917798#ent", "<e2>", "was", "tested", "in", "an", "experimental", "psychological", "study"], "h": {"id": "C0019471", "name": "C0019471#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "prolonged", "treatment", "with", "intranasally", "applied", "C0054201#ent", "<e1>", "was", "studied", "in", "twenty-four", "patients", "with", "C0035457#ent", "<e2>", "non-allergic", "rhinitis"], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [16, 17]}}
{"token": ["The", "present", "study", "showed", "that", "intranasally", "administered", "C0054201#ent", "<e1>", "is", "effective", "in", "the", "treatment", "of", "C0035457#ent", "<e2>"], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [15, 16]}}
{"token": ["Hereditary", "non-polyposis", "colorectal", "cancer", "C0879389#ent", "<e1>", ")", "is", "characterized", "C1516876#ent", "<e2>", "by", "germline", "mutations", "DNA", "mismatch", "repair", "MMR", ")", "genes", "."], "h": {"id": "C0879389", "name": "C0879389#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [9, 10]}}
{"token": ["The", "effect", "of", "C0015732#ent", "<e1>", "on", "quality", "of", "life", "with", "frequency", ",", "C0028734#ent", "<e2>", ",", "and", "pad", "use", "Kendall", "'s", "tau", "beta", "0.02", "-", "0.32", ",", "p", "<", "0.05", ")", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028734", "name": "C0028734#ent", "pos": [12, 13]}}
{"token": ["We", "demonstrated", "that", "the", "fusion", "proteins", "farnesylated", "by", "comparing", "the", "mobility", "of", "fusion", "proteins", "from", "a", "C2987364#ent", "<e1>", "strain", "and", "a", "C0138837#ent", "<e2>", "ste16/ram1", ")", "on", "SDS-gels", "and", "by", "an", "in", "vitro", "assay", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [21, 22]}}
{"token": ["Breast", "tumor", "models", "express", "C2987364#ent", "<e1>", "Ras", "have", "been", "shown", "to", "be", "sensitive", "to", "C0138837#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [14, 15]}}
{"token": ["When", "the", "low", "molecular", "weight", "tracer", "C0053653#ent", "<e1>", "was", "injected", "into", "the", "C0155365#ent", "<e2>", "rabbits", ",", "it", "subsequently", "accumulated", "in", "the", "somata", "and", "processes", "of", "a", "population", "of", "wide-field", "bipolar", "cells", "."], "h": {"id": "C0053653", "name": "C0053653#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0155365", "name": "C0155365#ent", "pos": [12, 13]}}
{"token": ["The", "order", "of", "hypolipidemic", "effectiveness", "ciprofibrate", "in", "hyperlipidemic", "rats", "provides", "a", "basis", "for", "anticipating", "that", "ciprofibrate", "will", "be", "hypolipidemic", "in", "C0020476#ent", "<e1>", "subjects", "who", "are", "considered", "at", "high", "risk", "acquiring", "C0010054#ent", "<e2>"], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [30, 31]}}
{"token": ["With", "the", "C1257902#ent", "<e1>", "but", "not", "the", "licking", "response", "C0237406#ent", "<e2>", "0.063", "and", "0.125", "mg/kg", "abolished", "the", "effect", "of", "morphine", "but", "did", "not", "modify", "that", "of", "CER", "and", "CCK-8", "."], "h": {"id": "C1257902", "name": "C1257902#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0237406", "name": "C0237406#ent", "pos": [9, 10]}}
{"token": ["Two", "types", "of", "summary", "measures", "of", "C0022408#ent", "<e1>", "evaluated", "in", "2", "controlled", "clinical", "trials", "C0003873#ent", "<e2>", "patients", "."], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["Induction", "of", "hyperplasia", "and", "dark", "basal", "keratinocytes", "C0268238#ent", "<e1>", ")", "and", "changes", "in", "the", "labeling", "index", "C1420713#ent", "<e2>", ")", "of", "basal", "keratinocytes", "DBA/2", "and", "C57BL/6", "mice", "treatment", "with", "sn-1,2-DDG", "were", "investigated", "."], "h": {"id": "C0268238", "name": "C0268238#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420713", "name": "C1420713#ent", "pos": [16, 17]}}
{"token": ["Conventional", "medical", "treatment", "C0010346#ent", "<e1>", "the", "use", "of", "non-specific", "anti-inflammatory", "drugs", "C0030125#ent", "<e2>", "prednisone", ",", "budesonide", ")", ",", "immunosuppressives", "(", "6-mercaptopurine", ",", "azathioprine", ",", "methotrexate", ")", "and", "antibiotics", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0030125", "name": "C0030125#ent", "pos": [11, 12]}}
{"token": ["Sulphasalazine", "(", "SASP", ")", ",", "used", "in", "the", "treatment", "of", "C0010346#ent", "<e1>", "is", "split", "into", "sulphapyridine", "(", "SP", ")", "and", "C0030125#ent", "<e2>", "5-ASA", ")", "in", "the", "colon", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0030125", "name": "C0030125#ent", "pos": [20, 21]}}
{"token": ["Secondary", ",", "the", "other", "rare", "causes", "of", "C0149911#ent", "<e1>", "are", "studied", ":", "sarcoidosis", "and", "C0018203#ent", "<e2>", "thyrotoxicosis", "and", "dome", "endocrinopathies", "immobilisation", "C0149911#ent", "<e1>", ",", "familial", "hypocalciuric", "C0149911#ent", "<e1>", "."], "h": {"id": "C0018203", "name": "C0018203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0149911", "name": "C0149911#ent", "pos": [7, 8]}}
{"token": ["Inhibition", "of", "nitric", "oxide", "synthase", "NG-nitro-L-arginine", "(", "30", "microM", ")", ",", "and", "of", "C0018358#ent", "<e1>", "methylene", "blue", "50", "microM", ")", "caused", "highly", "significant", "reductions", "of", "C1417685#ent", "<e2>", "relaxant", "responses", "whereas", "VIP-evoked", "relaxations", "were", "unaffected", "."], "h": {"id": "C0018358", "name": "C0018358#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417685", "name": "C1417685#ent", "pos": [25, 26]}}
{"token": ["On", "the", "other", "hand", ",", "C1416612#ent", "<e1>", "did", "not", "suppress", "the", "expression", "of", "C1416547#ent", "<e2>", ",", "Kv4.3", ",", "or", "hERG", "."], "h": {"id": "C1416612", "name": "C1416612#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416547", "name": "C1416547#ent", "pos": [13, 14]}}
{"token": ["An", "understanding", "of", "the", "mechanism", "by", "which", "minor", "C1511670#ent", "<e1>", "interact", "with", "DNA", "has", "led", "to", "the", "design", "of", "C0035064#ent", "<e2>", "that", "can", "reversibly", "bind", "with", "high", "selectivity", "to", "extended", "DNA", "target", "."], "h": {"id": "C1511670", "name": "C1511670#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [19, 20]}}
{"token": ["Hypergravity", "as", "low", "as", "50", "g", "transiently", "stimulated", "cultured", "mouse", "osteoblastic", "cells", "MC3T3-E1", ")", "to", "induce", "C1705964#ent", "<e1>", "such", "as", "c-fos", "and", "egr-1", ",", "whereas", "expression", "of", "C1623430#ent", "<e2>", "was", "marginally", "affected", "."], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [27, 28]}}
{"token": ["Familial", "pituitary", "tumor", "syndromes", "as", "C0406810#ent", "<e1>", "provide", "an", "important", "insight", "into", "the", "genetics", "and", "molecular", "pathology", "C0032002#ent", "<e2>", "and", "other", "endocrine", "tumors"], "h": {"id": "C0406810", "name": "C0406810#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [17, 18]}}
{"token": ["The", "beneficial", "antiarthritic", "effect", "of", "C0148634#ent", "<e1>", "has", "been", "also", "confirmed", "in", "patients", "with", "C0038013#ent", "<e2>"], "h": {"id": "C0148634", "name": "C0148634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [14, 15]}}
{"token": ["A", "56", "year", "old", "woman", "with", "C0003873#ent", "<e1>", "relapsing", "thrombocytopenia", "successive", "treatments", "with", "aurothioglucose", ",", "sulphasalazine", ",", "and", "C0020336#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [18, 19]}}
{"token": ["The", "drug", "is", "generally", "quite", "safe", "and", "could", "be", "used", "in", "low", "doses", "lupus", "and", "C0003873#ent", "<e1>", "patients", "as", "a", "steroid-sparing", "agent", "or", "synergistically", "with", "C0020336#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [25, 26]}}
{"token": ["However", ",", "C0012586#ent", "<e1>", "had", "no", "significant", "on", "brain", "C0907533#ent", "<e2>", "neuronal", "nitric", "oxide", "synthase", "activity", "."], "h": {"id": "C0012586", "name": "C0012586#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}}
{"token": ["Patients", "with", "pneumonia", ",", "C0206062#ent", "<e1>", "ILD", ")", ",", "or", "C0600260#ent", "<e2>", "COPD", ")", "were", "included", "."], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0600260", "name": "C0600260#ent", "pos": [10, 11]}}
{"token": ["The", "presence", "of", "inflammation", "and", "oxidative", "stress", "been", "established", "in", "C0206062#ent", "<e1>", "cystic", "fibrosis", "bronchiectasis", ",", "adult", "respiratory", "distress", "syndrome", "C0600260#ent", "<e2>", "asthma", "."], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0600260", "name": "C0600260#ent", "pos": [20, 21]}}
{"token": ["With", "nitrogen", "deprivation", "4", "or", "6", "h", ",", "the", "concentration", "of", "C1335208#ent", "<e1>", "decreased", "when", "compared", "to", "the", "standard", "C1366480#ent", "<e2>", "technique", "."], "h": {"id": "C1335208", "name": "C1335208#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366480", "name": "C1366480#ent", "pos": [19, 20]}}
{"token": ["Generation", "of", "radicals", "radiolytically", "in", "the", "presence", "of", "H", "donors", "formate", ",", "C0001002#ent", "<e1>", ",", "deoxyribose", ")", "indicate", "a", "chain", "reaction", "to", "H", "abstraction", "the", "C0013227#ent", "<e2>"], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [25, 26]}}
{"token": ["It", "was", "found", "that", "BMS-347070", ",", "when", "spray-dried", "with", "Pluronic", "F127", "C0001002#ent", "<e1>", "or", "methylene", "chloride", "was", "dispersed", "as", "nanosized", "crystalline", "C0013227#ent", "<e2>", "within", "the", "water-soluble", "Pluronic", "matrix", "."], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [21, 22]}}
{"token": ["The", "relationship", "between", "the", "C1413666#ent", "<e1>", "activation", "pathway", "bleeding", "complications", "associated", "with", "hemophilia", "A", "hemophilia", "B", "C1710605#ent", "<e2>", "requires", "further", "investigation", "."], "h": {"id": "C1413666", "name": "C1413666#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1710605", "name": "C1710605#ent", "pos": [16, 17]}}
{"token": ["C0700456#ent", "<e1>", "to", "be", "free", "of", "C0242896#ent", "<e2>", "assessed", "by", "the", "measurement", "of", "salivary", "volume", "pupil", "diameter", "the", "interactions", "with", "guanethidine", "and", "thymoxamine", "on", "the", "pupil", "."], "h": {"id": "C0700456", "name": "C0700456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [6, 7]}}
{"token": ["Syphilis", "was", "found", "to", "be", "the", "most", "common", "C1420519#ent", "<e1>", "in", "men", "(", "28.3", "%", ")", "and", "C0276828#ent", "<e2>", "in", "women", "(", "39.6", "%", ")", "."], "h": {"id": "C1420519", "name": "C1420519#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0276828", "name": "C0276828#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", "with", "full-length", "C1413668#ent", "<e1>", ",", "neither", "CPE-Delta4", "nor", "C3272367#ent", "<e2>", "sucrose", "density", "gradients", "."], "h": {"id": "C1413668", "name": "C1413668#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3272367", "name": "C3272367#ent", "pos": [10, 11]}}
{"token": ["As", "judged", "from", "tests", "for", "trypsin", ",", "temperature", "and", "ethanol", "sensitivity", ",", "the", "haemolytic", "activity", "was", "primarily", "dependent", "on", "C1538607#ent", "<e1>", "though", "the", "participation", "of", "C0031667#ent", "<e2>", "seemed", "probable", "."], "h": {"id": "C1538607", "name": "C1538607#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [25, 26]}}
{"token": ["It", "is", "concluded", "that", "this", "C1364818#ent", "<e1>", "formed", "from", "PrP", "and", "is", "therefore", "closely", "associated", "with", "C0036457#ent", "<e2>"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036457", "name": "C0036457#ent", "pos": [16, 17]}}
{"token": ["The", "interactions", "of", "C1412427#ent", "<e1>", ",", "calpactin", ",", "and", "p68", "(", "annexins", "VII", "C3273406#ent", "<e2>", ",", "and", "VI", ")", "with", "zymogen", "granules", "adrenal", "medullary", "granules", "were", "compared", "."], "h": {"id": "C1412427", "name": "C1412427#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "ET", "peptides", "play", "a", "significant", "role", "in", "this", "model", "of", "C0034063#ent", "<e1>", "may", "act", "as", "mediators", "of", "C0476273#ent", "<e2>"], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [21, 22]}}
{"token": ["Acute", "postnatal", "C0034063#ent", "<e1>", "to", "transient", "myocardial", "dysfunction", "an", "uncommon", "cause", "of", "C0476273#ent", "<e2>", "neonates", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [12, 13]}}
{"token": ["C0026975#ent", "<e1>", "observed", "in", "26", "cases", "including", "3", "C0270627#ent", "<e2>", "."], "h": {"id": "C0026975", "name": "C0026975#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0270627", "name": "C0270627#ent", "pos": [8, 9]}}
{"token": ["However", ",", "both", "the", "C3536850#ent", "<e1>", "inverse", "agonist", ",", "C0066212#ent", "<e2>", ",", "and", "pentylenetetrazole", "increased", "noradrenaline", "levels", "24", "h", "after", "injection", "."], "h": {"id": "C3536850", "name": "C3536850#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0066212", "name": "C0066212#ent", "pos": [9, 10]}}
{"token": ["In", "an", "elevated", "plus-maze", "model", "of", "anxiety", "mice", "treated", "with", "C3536850#ent", "<e1>", "inverse", "agonist", "C0066212#ent", "<e2>", "(", "0.5", "-", "1.5", "mg/kg", "i.p", ".", ")"], "h": {"id": "C3536850", "name": "C3536850#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0066212", "name": "C0066212#ent", "pos": [14, 15]}}
{"token": ["The", "intravenous", "administration", "the", "C3536850#ent", "<e1>", "inverse", "agonist", "C0066212#ent", "<e2>", "(", "6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylic", "acid", "methyl", "ester", ")", "dose-dependently", "reduced", "the", "efficacy", "of", "electrical", "stimulation", "the", "5-HT", "pathway", "depressing", "the", "firing", "activity", "rat", "hippocampus", "pyramidal", "neurons", "."], "h": {"id": "C3536850", "name": "C3536850#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0066212", "name": "C0066212#ent", "pos": [8, 9]}}
{"token": ["Administration", "of", "antibiotics", "previous", "to", "hospital", "admission", "increased", "duration", "of", "symptoms", ",", "and", "cardiac", "valve", "prosthesis", "C0038166#ent", "<e1>", "death", "were", "associated", "with", "C0001314#ent", "<e2>"], "h": {"id": "C0038166", "name": "C0038166#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001314", "name": "C0001314#ent", "pos": [22, 23]}}
{"token": ["C1416902#ent", "<e1>", "and", "HS+LPL", "protect", "bovine", "endothelial", "cells", "NK", "cytotoxicity", "by", "inducing", "C1539081#ent", "<e2>", ",", "CD154", "expression", ",", "and", "secretion", "of", "soluble", "factors", "."], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539081", "name": "C1539081#ent", "pos": [12, 13]}}
{"token": ["Though", "C0209368#ent", "<e1>", "are", "known", "as", "the", "substitute", "of", "asbestos", "and", "their", "toxicity", "are", "regarded", "as", "very", "low", ",", "C0209368#ent", "<e1>", "do", "not", "totally", "excluded", "from", "the", "respiratory", "and/or", "C0162628#ent", "<e1>", "."], "h": {"id": "C0209368", "name": "C0209368#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [29, 30]}}
{"token": ["Thus", ",", "progressive", "supranuclear", "palsy", "Parkinson's", "disease", "vertical", "gaze", "paralysis", "C0393593#ent", "<e1>", "dementia", ";", "multisystem", "atrophies", "to", "different", "degrees", "Parkinson's", "disease", "C0795996#ent", "<e2>", ",", "a", "cerebellar", "syndrome", "olivopontocerebellar", "atrophy", ",", "dysautonomia", "(", "Shy-Drager", "syndrome", ",", "pyramidal", "syndrome", "etc", "."], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0795996", "name": "C0795996#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "C1335238#ent", "<e1>", "enhanced", "in", "the", "presence", "of", "C2001522#ent", "<e2>"], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2001522", "name": "C2001522#ent", "pos": [9, 10]}}
{"token": ["RT-PCR", "analysis", "that", "zebrafish", "C1333668#ent", "<e1>", "expression", "was", "present", "only", "in", "the", "C0018050#ent", "<e2>", "and", "Northern", "blot", "analysis", "a", "single", "transcript", "of", "about", "2.0", "kb", "in", "the", "ovary", "."], "h": {"id": "C1333668", "name": "C1333668#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [12, 13]}}
{"token": ["The", "anticoagulant", "effect", "of", "antithrombin", "III", "C0724532#ent", "<e1>", ")", "in", "the", "management", "of", "C0012739#ent", "<e2>", "DIC", ")", "was", "investigated", "."], "h": {"id": "C0724532", "name": "C0724532#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [13, 14]}}
{"token": ["C0029904#ent", "<e1>", "and", "the", "low", "dose", "C0033051#ent", "<e2>", "exerted", "clear-cut", "positive", "inotropic", "effects", "reflected", "in", "increased", "stroke", "volume", "and", "max", "dF/dt", "without", "significant", "changes", "in", "heart", "rate", "arterial", "pressure"], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033051", "name": "C0033051#ent", "pos": [6, 7]}}
{"token": ["The", "PQ", "interval", "increased", "with", "C0029904#ent", "<e1>", "but", "decreased", "with", "C0033051#ent", "<e2>", "."], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033051", "name": "C0033051#ent", "pos": [10, 11]}}
{"token": ["Thus", "our", "3D", "receptor", "interaction", "model", "for", "C2985245#ent", "<e1>", "substrates", "and", "C0597607#ent", "<e2>", "lead", "to", "the", "rational", "design", "of", "selective", "C2985245#ent", "<e1>", "ligands", "as", "possible", "neuroprotective", "agents"], "h": {"id": "C0597607", "name": "C0597607#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2985245", "name": "C2985245#ent", "pos": [7, 8]}}
{"token": ["Lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "from", "E.", "coli", "inactivated", "C3273601#ent", "<e2>", "but", "neither", "the", "P1", "lysogens", "nor", "C2697656#ent", "<e1>", "derived", "from", "the", "lysogens", "inactivated", "C3273601#ent", "<e2>"], "h": {"id": "C3273601", "name": "C3273601#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}}
{"token": ["We", "observed", "6", "cases", "of", "secondary", "keratoconus", "C0152457#ent", "<e1>", "corneal", "epithelial", "C1166521#ent", "<e2>"], "h": {"id": "C0152457", "name": "C0152457#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [11, 12]}}
{"token": ["The", "carcinogenic", "compounds", "for", "specific", "discussion", "are", "N-nitroso", "alkylating", "agents", "the", "vinyl", "chloride", ",", "chloroacetaldehyde", "(", "C1842937#ent", "<e1>", ")", ",", "and", "the", "benzene", "metabolite", "C1096793#ent", "<e2>", "(", "p-BQ", ")", "."], "h": {"id": "C1842937", "name": "C1842937#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1096793", "name": "C1096793#ent", "pos": [24, 25]}}
{"token": ["The", "potential", "for", "inducing", "hypotension", "during", "fentanyl", "anaesthesia", "administering", "either", "C0012373#ent", "<e1>", "(", "n", "=", "7", ")", "or", "C0037533#ent", "<e2>", "n", "=", "7", ")", "was", "investigated", "during", "total", "hip", "arthroplasty"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [18, 19]}}
{"token": ["Poly(ADP-ribose)", "polymerase", "C1538577#ent", "<e1>", ")", "is", "a", "DNA", "binding", "C1421688#ent", "<e2>", "catalyzes", "the", "transfer", "of", "ADP-ribose", "residues", "NAD(+", ")", "to", "itself", "and", "different", "chromatin", "constituents", "forming", "branched", "ADP-ribose", "polymers", "."], "h": {"id": "C1538577", "name": "C1538577#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421688", "name": "C1421688#ent", "pos": [9, 10]}}
{"token": ["C1538577#ent", "<e1>", "PARP", ")", "is", "a", "DNA", "binding", "C1421688#ent", "<e2>", "catalyzes", "the", "transfer", "of", "ADP-ribose", "residues", "NAD(+", ")", "to", "itself", "and", "different", "chromatin", "constituents", "forming", "branched", "ADP-ribose", "polymers", "."], "h": {"id": "C1538577", "name": "C1538577#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421688", "name": "C1421688#ent", "pos": [8, 9]}}
{"token": ["To", "examine", "the", "role", "that", "cell", "cycle", "control", "genes", "play", "in", "this", "C1951340#ent", "<e1>", ",", "we", "investigated", "the", "steady", "state", "of", "C1707108#ent", "<e2>", "RNA", "during", "myogenesis", "of", "L6E9", "rat", "myoblasts", "."], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1707108", "name": "C1707108#ent", "pos": [21, 22]}}
{"token": ["Of", "these", ",", "anti-CD45RO", "inhibited", "phosphorylation", "of", "C0812317#ent", "<e1>", "and", "C0164786#ent", "<e2>", ",", "and", "PP2", "inhibited", "phosphorylation", "of", "C0812317#ent", "<e1>", "and", "C0164786#ent", "<e2>", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812317", "name": "C0812317#ent", "pos": [7, 8]}}
{"token": ["We", "also", "show", "that", "C1826563#ent", "<e1>", "associates", "with", "C0027877#ent", "<e2>", "when", "C0027877#ent", "<e2>", "accumulations", "become", "marked", "and", "correlate", "with", "susceptibility", "to", "neurodegenerative", "disease"], "h": {"id": "C1826563", "name": "C1826563#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027877", "name": "C0027877#ent", "pos": [8, 9]}}
{"token": ["Several", "studies", "have", "revealed", "that", "C0379528#ent", "<e1>", "important", "substrates", "besides", "C0085151#ent", "<e2>", "betaAPP", ")", "thus", "adding", "another", "level", "of", "complexity", "to", "designing", "fully", "AD-specific", "interfering", "drugs", "."], "h": {"id": "C0379528", "name": "C0379528#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [10, 11]}}
{"token": ["An", "unusual", "C0379528#ent", "<e1>", "functional", "presenilins", "and", "cleaves", "substrates", "(", "e.g.", "C0085151#ent", "<e2>", "Notch", ")", "with", "very", "loose", "amino", "acid", "sequence", "specificity", "within", "the", "transmembrane", "region"], "h": {"id": "C0379528", "name": "C0379528#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [11, 12]}}
{"token": ["EPO", "is", "also", "effective", "in", "human", "C0006111#ent", "<e1>", "as", "shown", "in", "double-blind", "placebo-controlled", "clinical", "studies", "C0948008#ent", "<e2>", "chronic", "schizophrenia"], "h": {"id": "C0006111", "name": "C0006111#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0948008", "name": "C0948008#ent", "pos": [15, 16]}}
{"token": ["A", "third", "A.", "thaliana", "PAL", "gene", "PAL3", ",", "differs", "significantly", "from", "C1428113#ent", "<e1>", "and", "PAL2", "and", "other", "sequenced", "plant", "PAL", "C0017337#ent", "<e2>", "."], "h": {"id": "C1428113", "name": "C1428113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "suggest", "C1428113#ent", "<e1>", "as", "a", "candidate", "C0017337#ent", "<e2>", "for", "MS", "susceptibility", "and", "pathogenesis", "."], "h": {"id": "C1428113", "name": "C1428113#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["To", "investigate", "the", "potential", "role", "of", "LT", "in", "the", "pathogenesis", "of", "human", "glomerulonephritis", "C1704321#ent", "<e1>", "we", "examined", "the", "gene", "expression", "C2348848#ent", "<e2>", "and", "LTA4", "hydrolase", "renal", "tissue", "21", "adult", "patients", "with", "C1704321#ent", "<e1>", "11", "controls", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2348848", "name": "C2348848#ent", "pos": [20, 21]}}
{"token": ["Accumulating", "data", "support", "a", "role", "for", "cardiomyocyte", "apoptosis", "in", "the", "development", "of", "several", "C0018799#ent", "<e1>", "including", "the", "transition", "from", "hypertensive", "compensatory", "hypertrophy", "C0018802#ent", "<e2>"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [22, 23]}}
{"token": ["More", "than", "90", "%", "of", "cases", "of", "congenital", "adrenal", "hyperplasia", "CAH", ")", "are", "caused", "by", "mutations", "of", "the", "CYP21", "gene", "result", "in", "C2713546#ent", "<e1>", "of", "the", "C1413861#ent", "<e2>"], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1413861", "name": "C1413861#ent", "pos": [26, 27]}}
{"token": ["One", "child", "had", "a", "human", "chorionic", "gonadotropin", "suggestive", "of", "17", "-", "20", "desmolase", "deficiency", "and", "on", "further", "evaluation", "he", "also", "had", "partial", "C2713546#ent", "<e1>", "of", "the", "C1413861#ent", "<e2>", "17", "alpha-hydroxylase", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1413861", "name": "C1413861#ent", "pos": [26, 27]}}
{"token": ["Two", "electrode", "voltage", "clamp", "conditions", "were", "used", "to", "study", "the", "early", "effects", "ionic", "membrane", "channels", "the", "intracellularly", "injected", "proto-oncogenic", "form", "C0079972#ent", "<e1>", "(", "c-ras", ")", "and", "its", "oncogenic", "counterpart", "v-Ha-ras", "(", "C1336923#ent", "<e2>", ")", "."], "h": {"id": "C0079972", "name": "C0079972#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1336923", "name": "C1336923#ent", "pos": [31, 32]}}
{"token": ["Using", "null", "cells", "ATF-3", "and", "for", "the", "C1335610#ent", "<e1>", "NF-kappaB", ",", "we", "showed", "that", "induction", "of", "apoptosis", "by", "C1418609#ent", "<e2>", "at", "late", "times", "infection", "was", "dependent", "on", "ATF-3", "expression", "and", "regulated", "by", "NF-kappaB", "activation"], "h": {"id": "C1335610", "name": "C1335610#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418609", "name": "C1418609#ent", "pos": [18, 19]}}
{"token": ["Some", "of", "the", "pathological", "mimics", "are", "iatrogenic", "while", "other", "common", "C0012634#ent", "<e1>", ",", "such", "as", "bacterial", "infection", "ischaemia", ",", "and", "C0810029#ent", "<e2>", "may", "produce", "confusing", "histological", "appearances", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0810029", "name": "C0810029#ent", "pos": [20, 21]}}
{"token": ["There", "was", "no", "direct", "C0747256#ent", "<e1>", "the", "nerve", "and", "there", "was", "no", "C0027813#ent", "<e2>", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027813", "name": "C0027813#ent", "pos": [12, 13]}}
{"token": ["For", "C0041296#ent", "<e1>", "and", "number", "of", "other", "C0004623#ent", "<e2>", "treatment", "with", "a", "single", "antimicrobial", "drug", "fails", "due", "to", "the", "ascent", "of", "mutants", "resistant", "to", "that", "drug", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}}
{"token": ["The", "study", "did", "not", "include", "children", "with", "inherited", "or", "acquired", "diseases", "the", "musculoskeletal", "system", "C1561643#ent", "<e1>", "the", "liver", "or", "kidneys", ",", "diabetes", ",", "C0040156#ent", "<e2>", "or", "malabsorption", "syndrome", "professional", "athletes"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040156", "name": "C0040156#ent", "pos": [23, 24]}}
{"token": ["The", "membrane-associated", "forms", "p115", "and", "C1335821#ent", "<e1>", "were", "fairly", "resistant", "to", "solubilization", "by", "nonionic", "detergents", "suggesting", "that", "C1706159#ent", "<e2>", "with", "the", "cytoskeletal", "matrix"], "h": {"id": "C1335821", "name": "C1335821#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706159", "name": "C1706159#ent", "pos": [17, 18]}}
{"token": ["Ang", "II", "stimulated", "DNA", "synthesis", "MOLT-3", "T", "cells", ",", "which", "was", "inhibited", "by", "C1418450#ent", "<e1>", ",", "olmesartan", ",", "an", "C1449680#ent", "<e2>", "an", "anti-oxidant", "N-acetylcysteine", "NAC", ")", ",", "or", "antibodies", "directed", "against", "IL-2", "."], "h": {"id": "C1418450", "name": "C1418450#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1449680", "name": "C1449680#ent", "pos": [19, 20]}}
{"token": ["C2931187#ent", "<e1>", "is", "the", "most", "common", "cause", "of", "the", "C0341703#ent", "<e2>", "children", ",", "leading", "to", "severe", "electrolyte", "disturbances", "and", "growth", "failure"], "h": {"id": "C2931187", "name": "C2931187#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0341703", "name": "C0341703#ent", "pos": [9, 10]}}
{"token": ["In", "this", "regard", ",", "organoselenium", "compounds", "C0121300#ent", "<e1>", "and", "peroxidases", "(", "e.g.", "C1415275#ent", "<e2>", "myeloperoxidase", ")", "exhibit", "high", "second-order", "rate", "constants", "with", "peroxynitrite", "."], "h": {"id": "C0121300", "name": "C0121300#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415275", "name": "C1415275#ent", "pos": [12, 13]}}
{"token": ["FKRP", "mutations", "account", "for", "a", "broad", "spectrum", "of", "patients", "with", "C0162674#ent", "<e1>", "from", "a", "severe", "congenital", "form", "or", "without", "mental", "retardation", "C1425226#ent", "<e2>", ")", "to", "a", "much", "milder", "limb-girdle", "muscular", "dystrophy", "LGMD2I", ")", "."], "h": {"id": "C0162674", "name": "C0162674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1425226", "name": "C1425226#ent", "pos": [21, 22]}}
{"token": ["Northern", "analyses", "showed", "that", "the", "induction", "pathway", "several", "of", "the", "C0341703#ent", "<e1>", "appeared", "to", "be", "altered", "in", "a", "number", "of", "clinical", "C1412553#ent", "<e2>", "isolates", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412553", "name": "C1412553#ent", "pos": [21, 22]}}
{"token": ["The", "C1425980#ent", "<e1>", "mRNAs", "both", "contain", "a", "291", "nucleotide", "open", "reading", "frame", ",", "preceded", "by", "a", "5'-untranslated", "region", "73", "nucleotides", "in", "C1419782#ent", "<e2>", "mRNA", "and", "of", "68", "nucleotides", "in", "murine", "C1425980#ent", "<e1>", "mRNA", "."], "h": {"id": "C1419782", "name": "C1419782#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1425980", "name": "C1425980#ent", "pos": [1, 2]}}
{"token": ["The", "role", "for", "C0757672#ent", "<e1>", "as", "modulators", "of", "C1705516#ent", "<e2>", "activity", "is", "discussed", ",", "as", "these", "molecules", "represent", "potential", "therapeutic", "targets", "given", "their", "cell", "type", "cyclic", "nucleotide", "specificities", "of", "action", "."], "h": {"id": "C0757672", "name": "C0757672#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705516", "name": "C1705516#ent", "pos": [8, 9]}}
{"token": ["Patients", "suffering", "from", "various", "renal", "diseases", "significantly", "higher", "activities", "of", "the", "C0005270#ent", "<e1>", "than", "individuals", "with", "essential", "hypertension", "or", "other", "C0029896#ent", "<e2>", "."], "h": {"id": "C0005270", "name": "C0005270#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [20, 21]}}
{"token": ["A", "murine", "model", "of", "endothelial", "cell", "injury-based", "vascular", "thrombosis", "used", "to", "test", "the", "role", "of", "platelet-endothelial", "cell", "adhesion", "molecule-1", "PECAM-1", ",", "C1706508#ent", "<e1>", ")", "in", "blood", "cell", "formation", "and", "C3275069#ent", "<e2>", "in", "vivo"], "h": {"id": "C1706508", "name": "C1706508#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3275069", "name": "C3275069#ent", "pos": [29, 30]}}
{"token": ["A", "murine", "model", "of", "endothelial", "cell", "injury-based", "vascular", "thrombosis", "used", "to", "test", "the", "role", "of", "platelet-endothelial", "cell", "adhesion", "molecule-1", "C1706508#ent", "<e1>", ",", "CD31", ")", "in", "blood", "cell", "formation", "and", "C3275069#ent", "<e2>", "in", "vivo"], "h": {"id": "C1706508", "name": "C1706508#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3275069", "name": "C3275069#ent", "pos": [29, 30]}}
{"token": ["A", "murine", "model", "of", "endothelial", "cell", "injury-based", "vascular", "thrombosis", "used", "to", "test", "the", "role", "of", "C1706508#ent", "<e1>", "PECAM-1", ",", "CD31", ")", "in", "blood", "cell", "formation", "and", "C3275069#ent", "<e2>", "in", "vivo"], "h": {"id": "C1706508", "name": "C1706508#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3275069", "name": "C3275069#ent", "pos": [26, 27]}}
{"token": ["The", "PKA-mediated", "release", "of", "MAP", "kinase", "HePTP", "is", "sufficient", "to", "activate", "the", "C0211705#ent", "<e1>", "and", "to", "induce", "transcription", "from", "the", "C1706383#ent", "<e2>", "promoter", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [20, 21]}}
{"token": ["The", "protein", "is", "identical", "to", "MIP-2A", ",", "which", "was", "shown", "to", "interact", "physically", "with", "C2364020#ent", "<e1>", "C1414402#ent", "<e2>", ")", "and", "relieve", "the", "regulatory", "role", "of", "C1414402#ent", "<e2>", "as", "a", "general", "transcription", "repressor"], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414402", "name": "C1414402#ent", "pos": [16, 17]}}
{"token": ["In", "normal", "mucosa", "basal", "cells", "strongly", "positive", "for", "C2364020#ent", "<e1>", "but", "negative", "for", "gamma-enolase", ",", "and", "columnar", "cells", "expressed", "both", "C1414402#ent", "<e2>", "."], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414402", "name": "C1414402#ent", "pos": [20, 21]}}
{"token": ["In", "the", "presence", "of", "nutrients", ",", "C0669365#ent", "<e1>", "elevated", "transcription", "of", "C1417092#ent", "<e2>", "is", "also", "sufficient", "for", "the", "translation", "of", "IME1", "RNA"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417092", "name": "C1417092#ent", "pos": [11, 12]}}
{"token": ["We", "utilized", "the", "well", "known", "phenomenon", "of", "C0064833#ent", "<e1>", "PMN", ")", "migration", "to", "the", "C0206064#ent", "<e2>", "a", "result", "of", "acute", "inflammatory", "reactions", "from", "the", "damaged", "cells", "."], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0206064", "name": "C0206064#ent", "pos": [14, 15]}}
{"token": ["Based", "on", "such", "biochemical", "abnormalities", "number", "of", "similar", "genetic", "disorders", "as", "neonatal", "C1412084#ent", "<e1>", ",", "different", "forms", "of", "chondrodysplasia", "punctata", "C0282527#ent", "<e2>", "."], "h": {"id": "C1412084", "name": "C1412084#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282527", "name": "C0282527#ent", "pos": [20, 21]}}
{"token": ["Thermal", "stress", "causes", "decreased", "protein", "synthesis", "well", "as", "rapid", "induction", "of", "heat", "shock", "proteins", "C0085292#ent", "<e1>", ")", ",", "or", "alternately", "termed", "stress", "proteins", "C1843919#ent", "<e2>", ")", "."], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1843919", "name": "C1843919#ent", "pos": [23, 24]}}
{"token": ["Tumour", "necrosis", "factor", "alpha", "interleukin", "6", "altered", "DNA", "synthesis", "whereas", "hepatocyte", "growth", "factor", "HGF", ")", ",", "C0064294#ent", "<e1>", "KGF", ")", "and", "the", "C1704816#ent", "<e2>", "HB-EGF", ")", "were", "potent", "inducers", "of", "DNA", "replication", "both", ",", "GSTp-neg", "and", "GSTp-pos", "cells", "."], "h": {"id": "C0064294", "name": "C0064294#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704816", "name": "C1704816#ent", "pos": [22, 23]}}
{"token": ["These", "C0004509#ent", "<e1>", "spermatogenic", "defects", "similar", "to", "some", "human", "C0151721#ent", "<e2>", "patients", "."], "h": {"id": "C0004509", "name": "C0004509#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0151721", "name": "C0151721#ent", "pos": [9, 10]}}
{"token": ["Within", "the", "C0004509#ent", "<e1>", "the", "values", "were", "not", "significantly", "different", "between", "those", "with", "C0151721#ent", "<e2>", "obstruction", "."], "h": {"id": "C0004509", "name": "C0004509#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0151721", "name": "C0151721#ent", "pos": [13, 14]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "evaluate", "efficacy", "and", "safety", "of", "the", "treatment", "with", "interferon", "alpha", "C1415900#ent", "<e1>", ")", "and", "ribavirin", "in", "C0684275#ent", "<e2>", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0684275", "name": "C0684275#ent", "pos": [23, 24]}}
{"token": ["The", "major", "C1414463#ent", "<e1>", "splice", "variants", "in", "the", "hippocampus", "were", "found", "to", "be", "C3890197#ent", "<e2>", "and", "del.4", "."], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3890197", "name": "C3890197#ent", "pos": [13, 14]}}
{"token": ["Twelve", "patients", "suffering", "from", "C0003873#ent", "<e1>", "having", "swollen", "knees", "treated", "with", "g/day", "of", "C0546873#ent", "<e2>", "administered", "in", "one", "dose", ",", "daily", "for", "5", "days", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0546873", "name": "C0546873#ent", "pos": [13, 14]}}
{"token": ["The", "effects", "of", "intravenously", "administered", "C0025379#ent", "<e1>", ",", "tolperisone", ",", "baclofen", ",", "diazepam", "and", "C0026056#ent", "<e2>", "on", "reflex", "activity", "studied", "in", "unanesthetized", "spinal", "cats"], "h": {"id": "C0025379", "name": "C0025379#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrate", "that", "the", "SEFIR", "domain", "mediates", "C1825593#ent", "<e1>", "signaling", "independently", "of", "classic", "TIR", "adaptors", "such", "as", "C1417530#ent", "<e2>", "and", "TRIF", "."], "h": {"id": "C1825593", "name": "C1825593#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417530", "name": "C1417530#ent", "pos": [17, 18]}}
{"token": ["Tumor", "necrosis", "factor-alpha", "C0812246#ent", "<e1>", ")", "release", "has", "been", "implicated", "in", "a", "C0242966#ent", "<e2>", "cardiopulmonary", "bypass", "CPB", ")", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242966", "name": "C0242966#ent", "pos": [12, 13]}}
{"token": ["Given", "their", "binding", "properties", ",", "association", "with", "the", "C0286330#ent", "<e1>", "and", "widespread", "distribution", ",", "C2347054#ent", "<e2>", ",", "S5a", ",", "and", "related", "proteins", "likely", "function", "as", "essential", "ubiquitin", "recognition", "components", "of", "the", "C0286330#ent", "<e1>"], "h": {"id": "C0286330", "name": "C0286330#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2347054", "name": "C2347054#ent", "pos": [14, 15]}}
{"token": ["Inhibitors", "of", "tyrosine", "kinase", "A", "kinase", ",", "G", "kinase", "and", "C0027120#ent", "<e1>", "not", "induce", "such", "a", "rapid", "and", "specific", "decrease", "of", "C0059239#ent", "<e2>", "."], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [21, 22]}}
{"token": ["C0117996#ent", "<e1>", "inhalation", "exerted", "no", "influence", "on", "the", "increased", "bronchial", "responsiveness", "C0600370#ent", "<e2>", "induced", "by", "exposure", "."], "h": {"id": "C0117996", "name": "C0117996#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [11, 12]}}
{"token": ["It", "is", "active", "against", "C0085426#ent", "<e1>", "several", "fungi", ",", "yeasts", "and", "C0026936#ent", "<e2>", "."], "h": {"id": "C0085426", "name": "C0085426#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026936", "name": "C0026936#ent", "pos": [11, 12]}}
{"token": ["Group", "II", "43", "patients", ",", "were", "treated", "with", "mg", "C0700599#ent", "<e1>", "and", "50", "mg", "C0034283#ent", "<e2>", "(", "2", "tablets", "of", "Fansidar", ")", "."], "h": {"id": "C0700599", "name": "C0700599#ent", "pos": [9, 10]}, "relation": "has_constitutional_part", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [14, 15]}}
{"token": ["Fansimef", "is", "a", "combination", "of", "250", "mg", "mefloquine", "(", "base", ")", ",", "500", "mg", "C0700599#ent", "<e1>", ",", "and", "25", "mg", "C0034283#ent", "<e2>", "per", "tablet", "."], "h": {"id": "C0700599", "name": "C0700599#ent", "pos": [14, 15]}, "relation": "has_constitutional_part", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [20, 21]}}
{"token": ["The", "syndrome", "'s", "main", "features", "are", "microbrachycephaly", "and", "peculiar", "face", ",", "mental", "deficiency", "euphoria", "and", "laughter", ",", "C0007758#ent", "<e1>", "and", "epilepsy", "consisting", "in", "C3887898#ent", "<e2>", "grand-mal", "attacks"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3887898", "name": "C3887898#ent", "pos": [23, 24]}}
{"token": ["The", "substrate", "specificity", "was", "analysed", "with", "crude", "extracts", "H.", "pylori", "cells", "in", "vitro", "the", "best", "substrates", "were", "C0072185#ent", "<e1>", ",", "acrylamide", "and", "C0050423#ent", "<e2>", "."], "h": {"id": "C0072185", "name": "C0072185#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0050423", "name": "C0050423#ent", "pos": [22, 23]}}
{"token": ["BFA", "decreased", "to", "zero", "the", "proportion", "of", "C0599220#ent", "<e1>", "which", "were", "totally", "C1427293#ent", "<e2>", "H-resistant", ",", "while", "it", "increased", "the", "proportion", "which", "were", "partially", "C1427293#ent", "<e2>", "H-resistant", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1427293", "name": "C1427293#ent", "pos": [12, 13]}}
{"token": ["In", "the", "retroperitoneal", "adipose", "tissue", "a", "patient", "with", "Cushing's", "syndrome", "8", "%", "of", "C0599220#ent", "<e1>", "were", "partially", "C1427293#ent", "<e2>", "H-sensitive", "and", "92", "%", "were", "totally", "C1427293#ent", "<e2>", "H-sensitive", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1427293", "name": "C1427293#ent", "pos": [17, 18]}}
{"token": ["Our", "preliminary", "studies", "indicate", "that", "cultured", "skin", "fibroblasts", "from", "C0011854#ent", "<e1>", "patients", "with", "nephropathy", "have", "an", "enhanced", "C1705761#ent", "<e2>", "phosphorylation", ",", "cyclin", "D1", "protein", "expression", ",", "and", "cyclin", "D1/CDK4(6", ")", "kinase", "activity", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705761", "name": "C1705761#ent", "pos": [17, 18]}}
{"token": ["C1427656#ent", "<e1>", ",", "but", "not", "Mps1", "or", "C0659150#ent", "<e2>", ",", "was", "rapidly", "phosphorylated", "in", "response", "to", "increased", "osmolarity", "."], "h": {"id": "C1427656", "name": "C1427656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0659150", "name": "C0659150#ent", "pos": [7, 8]}}
{"token": ["These", "data", "suggest", "that", "SSK1", "and", "C1427656#ent", "<e1>", "indirectly", "or", "directly", "negatively", "regulate", "C0659150#ent", "<e2>", "under", "most", "growth", "conditions", "tested", "."], "h": {"id": "C1427656", "name": "C1427656#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0659150", "name": "C0659150#ent", "pos": [13, 14]}}
{"token": ["Excessive", "accumulation", "of", "C1537574#ent", "<e1>", ",", "however", ",", "is", "associated", "with", "C0029896#ent", "<e2>", "such", "as", "obesity", ",", "diabetes", "mellitus", "and", "steatohepatitis", "."], "h": {"id": "C1537574", "name": "C1537574#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["Along", "with", "coactivators", "that", "possess", "histone", "acetyltransferase", "C1540026#ent", "<e1>", ")", "or", "methyltransferase", "activity", "other", "coactivators", "that", "lack", "recognizable", "C1538455#ent", "<e2>", "been", "discovered", "whose", "mechanism", "of", "action", "is", "largely", "unknown", "."], "h": {"id": "C1540026", "name": "C1540026#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538455", "name": "C1538455#ent", "pos": [18, 19]}}
{"token": ["This", "pilot", "study", "the", "feasibility", "of", "intravitreal", "injections", "of", "tissue", "plasminogen", "activator", "C0872913#ent", "<e1>", ")", "in", "eyes", "with", "C0035328#ent", "<e2>", "CRVO", ")", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035328", "name": "C0035328#ent", "pos": [18, 19]}}
{"token": ["Newer", "therapeutic", "agents", "including", "vasopressin", "antagonists", "C2936829#ent", "<e1>", "hold", "promise", "for", "the", "future", ",", "and", "clinical", "trials", "these", "C0991617#ent", "<e2>", "are", "underway", "."], "h": {"id": "C2936829", "name": "C2936829#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [18, 19]}}
{"token": ["Both", "immunophilins", "were", "also", "ubiquitously", "expressed", "in", "breast", "carcinomas", "and", "we", "demonstrate", "for", "the", "first", "time", "that", "both", "CyP40", "and", "C0209554#ent", "<e1>", "mRNA", "are", "C3889446#ent", "<e2>", "in", "breast", "tumors", "to", "matched", "normal", "breast", "controls"], "h": {"id": "C0209554", "name": "C0209554#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [24, 25]}}
{"token": ["Main", "signs", "and", "symptoms", "were", "dysesthesia", "of", "the", "upper", "extremities", "C0151315#ent", "<e1>", "dizziness", "and", "C0011168#ent", "<e2>", "(", "33", "%", ")", "."], "h": {"id": "C0151315", "name": "C0151315#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [14, 15]}}
{"token": ["In", "the", "absence", "of", "C1418887#ent", "<e1>", ",", "we", "found", "that", "C1308278#ent", "<e2>", "overexpression", "reduces", "lysis", "of", "tumor", "cells", "NK", "cells", "in", "vitro", "in", "vivo"], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1308278", "name": "C1308278#ent", "pos": [10, 11]}}
{"token": ["A", "series", "of", "8", "patients", "(", "12", "C0235267#ent", "<e1>", ")", "with", "ocular", "ischemic", "syndrome", "ocular", "signs", "symptoms", "due", "to", "severe", "C0003838#ent", "<e2>", "is", "presented", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003838", "name": "C0003838#ent", "pos": [20, 21]}}
{"token": ["BSI-B4", "reacted", "strongly", "with", "both", "the", "B", "active", "glycoprotein", "purified", "from", "human", "C0029927#ent", "<e1>", "fluid", "and", "a", "C0072522#ent", "<e2>", "isolated", "from", "sheep", "hydatid", "fluid", "and", "precipitated", "over", "86", "%", "of", "the", "lectin", "nitrogen", "."], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [17, 18]}}
{"token": ["Rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "is", "frequently", "complicated", "by", "C0836924#ent", "<e2>", "correlated", "with", "disease", "activity"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0836924", "name": "C0836924#ent", "pos": [9, 10]}}
{"token": ["The", "phosphatase-induced", "shift", "in", "the", "electrophoretic", "mobility", "C1415075#ent", "<e1>", "is", "not", "reversed", "by", "this", "C0033640#ent", "<e2>", "indicating", "that", "C1415075#ent", "<e1>", "is", "likely", "phosphorylated", "on", "different", "residues", "by", "two", "or", "more", "protein", "kinases"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1415075", "name": "C1415075#ent", "pos": [7, 8]}}
{"token": ["In", "extracts", "from", "CMV-infected", "cells", ",", "the", "CMV", "C0082328#ent", "<e1>", "found", "strongly", "associated", "with", "additional", "polypeptide", ",", "C4084872#ent", "<e2>", "."], "h": {"id": "C0082328", "name": "C0082328#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4084872", "name": "C4084872#ent", "pos": [17, 18]}}
{"token": ["While", "glomerular", "lesions", "a", "recognized", "sequel", "to", "infection", "with", "group", "A", "beta", "haemolytic", "streptococci", "literature", "on", "C1402294#ent", "<e1>", "as", "remote", "effects", "of", "C0038395#ent", "<e2>", "is", "scanty", "."], "h": {"id": "C1402294", "name": "C1402294#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038395", "name": "C0038395#ent", "pos": [22, 23]}}
{"token": ["A", "high", "correlation", "coefficient", "r", "approximately", "0.9", ")", "was", "obtained", "between", "C0036579#ent", "<e1>", "binding", "and", "monoamine", "oxidase-B", "activity", ",", "both", "in", "the", "senile", "dementia", "C0002395#ent", "<e2>", "in", "the", "control", "brains"], "h": {"id": "C0036579", "name": "C0036579#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [24, 25]}}
{"token": ["One", "patient", ",", "who", "was", "specifically", "treated", "for", "C0002726#ent", "<e1>", "by", "melphalan", "and", "C0011777#ent", "<e2>", ",", "died", "1", "wk", "after", "therapy", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [13, 14]}}
{"token": ["Despite", "frequent", "descriptions", "of", "C0149911#ent", "<e1>", ",", "cases", "accompanied", "by", "diabetes", "insipidus", "C0039082#ent", "<e2>", "of", "inappropriate", "secretion", "of", "anti-diuretic", "hormone", "SIADH", ")", "in", "ATL", "patients", "have", "rarely", "been", "reported", "."], "h": {"id": "C0149911", "name": "C0149911#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}}
{"token": ["Almost", "all", "the", "ATP", "sulfurylase", "activity", "was", "located", "in", "the", "bundle", "sheath", "chloroplasts", "while", "C0010663#ent", "<e1>", "cystathionine", "beta-lyase", "activity", "located", ",", "in", "different", "proportions", ",", "in", "both", "C3179066#ent", "<e2>"], "h": {"id": "C0010663", "name": "C0010663#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [27, 28]}}
{"token": ["Focal", "adhesion", "kinase", "the", "recently", "identified", "proline-rich", "tyrosine", "kinase", "2", "PYK2", ")", ",", "also", "known", "as", "C1333206#ent", "<e1>", "bgr", ";", ",", "related", "C0059239#ent", "<e2>", "calcium-dependent", "protein", "tyrosine", "kinase", "define", "a", "new", "family", "of", "non-receptor", "protein", "tyrosine", "kinases"], "h": {"id": "C1333206", "name": "C1333206#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [22, 23]}}
{"token": ["Instead", "of", "being", "two", "completely", "distinct", "disease", "entities", "DSS", "and", "C0270911#ent", "<e1>", "form", "a", "spectrum", "of", "inherited", "C2700453#ent", "<e2>", "related", "neuropathies", ",", "including", "hereditary", "neuropathy", "liability", "to", "pressure", "palsies", "carries", "a", "deletion", "of", "the", "PMP-22", "gene"], "h": {"id": "C0270911", "name": "C0270911#ent", "pos": [10, 11]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C2700453", "name": "C2700453#ent", "pos": [17, 18]}}
{"token": ["C3714757#ent", "<e1>", "JIA", ")", "is", "the", "most", "common", "C0022408#ent", "<e2>", "in", "witch", "an", "inflammatory", "process", "lead", "not", "only", "to", "fixed", "deformities", "also", "to", "developmental", "disturbances", "including", "growth", "inhibition"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [8, 9]}}
{"token": ["Two", "of", "the", "patients", "had", "untreated", "C3714757#ent", "<e1>", "three", "had", "a", "pyogenic", "joint", "infection", "four", "had", "Henoch-Schonlein", "purpura", "eight", "had", "C0022408#ent", "<e2>"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [20, 21]}}
{"token": ["GATA-1", "is", "a", "C0919490#ent", "<e1>", "expressed", "in", "erythroid", ",", "megakaryocytic", ",", "mast", "cell", "C0014457#ent", "<e2>", "lineages", "."], "h": {"id": "C0919490", "name": "C0919490#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [13, 14]}}
{"token": ["The", "viral", "enzyme", "like", "all", "other", "characterized", "C0077845#ent", "<e1>", "is", "active", "in", "the", "presence", "of", "high", "concentrations", "of", "C0013618#ent", "<e2>", ",", "is", "substrate", "inhibited", "by", "uracil", ",", "and", "does", "not", "display", "any", "endonuclease", "activity"], "h": {"id": "C0077845", "name": "C0077845#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [18, 19]}}
{"token": ["All", "three", "C3541394#ent", "<e1>", "bound", "similarly", "to", "C1451270#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1451270", "name": "C1451270#ent", "pos": [7, 8]}}
{"token": ["C0002982#ent", "<e1>", "not", "previously", "been", "reported", "in", "cases", "of", "C0005283#ent", "<e2>", ",", "and", "the", "question", "whether", "this", "is", "a", "chance", "association", "or", "otherwise", "is", "discussed", "."], "h": {"id": "C0002982", "name": "C0002982#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [9, 10]}}
{"token": ["Genotypes", "identified", "by", "two", "restriction", "fragment", "length", "polymorphisms", "RFLPs", ")", "of", "the", "insulin", "receptor", "gene", "IRG", ")", "with", "the", "C0012906#ent", "<e1>", "determined", "in", "a", "Japanese", "group", "comprising", "51", "patients", "with", "C0011860#ent", "<e2>", "NIDDM", ")", "and", "50", "control", "subjects"], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [30, 31]}}
{"token": ["The", "thrombolytic", "and", "systemic", "effects", "BM", "06.022", "were", "evaluated", "and", "compared", "with", "those", "of", "alteplase", ",", "C0078956#ent", "<e1>", ",", "streptokinase", "and", "urokinase", "in", "a", "canine", "model", "of", "C0010072#ent", "<e2>"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010072", "name": "C0010072#ent", "pos": [27, 28]}}
{"token": ["These", "clinical", "data", "suggest", "that", "C0961209#ent", "<e1>", "0.1", "%", "is", "a", "promising", "C0013227#ent", "<e2>", "for", "the", "treatment", "of", "posterior", "segment", "inflammation", ",", "including", "CME", ",", "and", "warrants", "further", "investigation", "."], "h": {"id": "C0961209", "name": "C0961209#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["We", "earlier", "identified", "the", "GTPBP1", "gene", "encodes", "a", "putative", "C0018296#ent", "<e1>", "structurally", "related", "to", "C0059036#ent", "<e2>"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [9, 10]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [14, 15]}}
{"token": ["One", "patient", "exhibited", "C0034372#ent", "<e1>", "and", "the", "other", "two", "only", "had", "C0030554#ent", "<e2>", "of", "the", "upper", "and/or", "lower", "extremities", "at", "the", "scene", "of", "the", "accident", "."], "h": {"id": "C0034372", "name": "C0034372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030554", "name": "C0030554#ent", "pos": [11, 12]}}
{"token": ["Enzyme", "activity", "maximally", "preserved", "by", "embedding", "the", "freeze-dried", "tissue", "specimens", "in", "C1880991#ent", "<e1>", "-20", "degrees", "C.", "The", "C0022917#ent", "<e2>", "were", "accurately", "localized", "without", "any", "diffusion", "when", "the", "tissue", "sections", "incubated", "in", "aqueous", "media", "."], "h": {"id": "C1880991", "name": "C1880991#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022917", "name": "C0022917#ent", "pos": [17, 18]}}
{"token": ["When", "compared", "with", "other", "well-studied", "fluoroquinolones", "in", "vitro", "C1332397#ent", "<e1>", "and", "Lomefloxacin", "(", "C2938202#ent", "<e2>", ")", "were", "equally", "effective", "in", "producing", "chromosome", "damage", "DNA", "strand", "breakage", "Chinese", "hamster", "ovary", "CHO", ")", "cells", "exposed", "to", "UVA", "."], "h": {"id": "C1332397", "name": "C1332397#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2938202", "name": "C2938202#ent", "pos": [13, 14]}}
{"token": ["C0917728#ent", "<e1>", "one", "of", "three", "C0669365#ent", "<e2>", "viral", "enzymes", "for", "replication", ",", "is", "an", "attractive", "target", "for", "chemotherapeutic", "intervention", "the", "treatment", "of", "AIDS", "."], "h": {"id": "C0917728", "name": "C0917728#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [5, 6]}}
{"token": ["These", "C0991617#ent", "<e1>", "also", "have", "been", "shown", "to", "improve", "quality", "of", "life", "women", "with", "C0878773#ent", "<e2>", "urinary", "incontinence"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0878773", "name": "C0878773#ent", "pos": [14, 15]}}
{"token": ["This", "report", "describes", "the", "determinations", "observed", "on", "the", "antiepileptic", "drug", "Carbamazepine", ",", "the", "two", "antiphlogistics", "and", "analgesics", "C0012091#ent", "<e1>", "and", "Ibuprofen", "and", "the", "lipid", "regulator", "C0005330#ent", "<e2>", "."], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0005330", "name": "C0005330#ent", "pos": [25, 26]}}
{"token": ["Lengthening", "the", "ethyl", "chain", "of", "C0010648#ent", "<e1>", "by", "one", "methylene", "group", "to", "partial", "C2987634#ent", "<e2>", "of", "decreased", "activity", "."], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}}
{"token": ["T", "cells", "isolated", "from", "PBMCs", "and", "SFMCs", "of", "PsA", "patients", "C3889446#ent", "<e1>", "RANKL", "and", "C1710304#ent", "<e2>", ",", "and", "fibroblasts", "from", "SFMCs", "C3889446#ent", "<e1>", "RANKL", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [14, 15]}}
{"token": ["We", "conducted", "a", "quantitative", "analysis", "TERT", ",", "C1336603#ent", "<e1>", "and", "hTR", "mRNA", "expression", "in", "various", "types", "of", "C0014173#ent", "<e2>", "perimenopausal", "women", ",", "taking", "advantage", "of", "the", "real-time", "PCR", "assay"], "h": {"id": "C1336603", "name": "C1336603#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014173", "name": "C0014173#ent", "pos": [17, 18]}}
{"token": ["Using", "C0031669#ent", "<e1>", "of", "Bacillus", "thuringiensis", "subcellular", "fractionation", "Percoll", "gradient", "centrifugation", "we", "found", "that", "chicken", "C2932861#ent", "<e2>", "be", "transferred", "from", "plasma", "membrane", "lysosomes", "in", "the", "GPI-anchored", "or", "soluble", "form", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2932861", "name": "C2932861#ent", "pos": [15, 16]}}
{"token": ["Glycosaminoglycan", "analysis", "significant", "amounts", "of", "chondroitin", "6-", "4-sulfate", "in", "unfractionated", "culture", "medium", "in", "those", "C1418888#ent", "<e1>", "fractions", "generated", "from", "culture", "medium", "dA1", ",", "dA2", "and", "C3540507#ent", "<e2>", ")", "."], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540507", "name": "C3540507#ent", "pos": [25, 26]}}
{"token": ["The", "majority", "of", "the", "atopic", "patients", "showed", "a", "strong", "IgG", "and", "IgA", "antibody", "response", "towards", "C0053413#ent", "<e1>", ",", "a", "carbohydrate", ",", "but", "only", "occasionally", "to", "C0086376#ent", "<e2>", "."], "h": {"id": "C0053413", "name": "C0053413#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [25, 26]}}
{"token": ["The", "blockers", "of", "mu-", "and", "delta-opioid", "receptors", "reduced", "the", "C0003195#ent", "<e1>", "the", "adaptation", ",", "whereas", "chi-receptor", "inhibitor", ",", "C0068961#ent", "<e2>", ",", "completely", "abolished", "it", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0068961", "name": "C0068961#ent", "pos": [18, 19]}}
{"token": ["The", "protease", "inhibited", "is", "C0007427#ent", "<e1>", "released", "from", "the", "lysosome", "during", "C0015133#ent", "<e2>", "treatment", "."], "h": {"id": "C0007427", "name": "C0007427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [11, 12]}}
{"token": ["C0060926#ent", "<e1>", "is", "an", "C0003299#ent", "<e2>", "in", "a", "variety", "of", "chronic", "pain", "conditions"], "h": {"id": "C0060926", "name": "C0060926#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [4, 5]}}
{"token": ["Treatment", "with", "cyclosporine", "is", "beneficial", "for", "many", "C0037274#ent", "<e1>", "as", "psoriasis", ",", "lichen", "planus", "Beh\u00e7et", "disease", "atopic", "dermatitis", "pyoderma", "gangrenosum", "and", "C0079293#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0079293", "name": "C0079293#ent", "pos": [21, 22]}}
{"token": ["Increased", "dietary", "protein", "shortened", "C0019469#ent", "<e1>", "and", "C0033218#ent", "<e2>", "paralysis", "time", ",", "and", "increased", "C0033218#ent", "<e2>", "lethality", ",", "whereas", "low", "protein", "intake", "against", "bromobenzene", "hepatotoxicity", "."], "h": {"id": "C0019469", "name": "C0019469#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033218", "name": "C0033218#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "while", "C0729078#ent", "<e1>", "decreased", "the", "C1839163#ent", "<e2>", "associated", "with", "mitomycin", "therapy", "mitomycin", "was", "ineffective", "in", "the", "treatment", "of", "refractory", "colorectal", "carcinoma"], "h": {"id": "C0729078", "name": "C0729078#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [7, 8]}}
{"token": ["However", ",", "both", "IGF-BP3", "and", "C1705677#ent", "<e1>", "were", "capable", "of", "inhibiting", "both", "forskolin-", "and", "C0008354#ent", "<e2>", "toxin-stimulated", "steroidogenesis", ",", "confirming", "that", "neither", "compound", "was", "competing", "with", "FSH", "for", "binding", "to", "its", "receptor", "."], "h": {"id": "C1705677", "name": "C1705677#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008354", "name": "C0008354#ent", "pos": [14, 15]}}
{"token": ["The", "C1667078#ent", "<e1>", "caspase-3", "may", "be", "involved", "in", "the", "mechanism", "of", "cell", "death", "C0036572#ent", "<e2>", "."], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["The", "inhibitory", "mechanisms", "of", "thiazole-4-carboxamide", "adenine", "dinucleotide", "TAD", ")", "and", "ribavirin", "5'-monophosphate", "RMP", ")", ",", "the", "active", "forms", "the", "antimetabolites", "C0076656#ent", "<e1>", "and", "ribavirin", ",", "were", "investigated", "on", "the", "purified", "C0027203#ent", "<e2>", "."], "h": {"id": "C0076656", "name": "C0076656#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [30, 31]}}
{"token": ["C0076656#ent", "<e1>", "inhibits", "the", "C0027203#ent", "<e2>", "after", "metabolic", "conversion", "into", "thiazole-4-carboxamide", "adenine", "dinucleotide", "TAD", ")", ",", "an", "analogue", "of", "the", "cofactor", "NAD", "."], "h": {"id": "C0076656", "name": "C0076656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}}
{"token": ["NIH", "3T3", "MC", "3T3", "and", "C0812281#ent", "<e1>", "17/2.8", "cells", "showed", "the", "expected", "nuclear", "localization", "Cbfa1", ",", "whereas", "C1336578#ent", "<e2>", "was", "distributed", "throughout", "the", "cytoplasm", "with", "some", "nuclear", "localization", "transfected", "with", "either", "Cbfa1", "or", "C1336578#ent", "<e2>", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336578", "name": "C1336578#ent", "pos": [17, 18]}}
{"token": ["The", "excess", "of", "C1413916#ent", "<e1>", "and", "bromine", "can", "be", "removed", "with", "C0075593#ent", "<e2>", "without", "boiling", "."], "h": {"id": "C1413916", "name": "C1413916#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0075593", "name": "C0075593#ent", "pos": [11, 12]}}
{"token": ["Indeed", ",", "dopamine", "inhibited", "C0027293#ent", "<e1>", "with", "IC50", "=", "8", "microM", ",", "and", "that", "of", "C3887648#ent", "<e2>", "was", "twice", "as", "much", "(", "IC50", "=", "15", "microM", ")", "."], "h": {"id": "C0027293", "name": "C0027293#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [15, 16]}}
{"token": ["Neither", "C0034348#ent", "<e1>", "although", "known", "for", "its", "binding", "to", "actin", ",", "nor", "C1418508#ent", "<e2>", "PGK", ")", ",", "not", "directly", "interacting", "with", "the", "I-band", "itself", ",", "did", "mediate", "I-band", "targeting", "of", "MM-CK", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418508", "name": "C1418508#ent", "pos": [12, 13]}}
{"token": ["Proton", "pump", "inhibitors", "PPIs", ")", ",", "such", "as", "omeprazole", ",", "lansoprazole", ",", "rabeprazole", ",", "esomeprazole", ",", "and", "C0081876#ent", "<e1>", ",", "are", "metabolized", "by", "C0960580#ent", "<e2>", "CYP2C19", ")", "in", "the", "liver", "."], "h": {"id": "C0081876", "name": "C0081876#ent", "pos": [17, 18]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "provide", "evidence", "that", "G", "protein-coupled", "receptor", "kinase", "1", "C1335620#ent", "<e1>", ")", ",", "which", "is", "most", "similar", "to", "the", "beta-adrenergic", "receptor", "kinases", "C1384522#ent", "<e2>", "GRK2", ")", "and", "GRK3", ",", "is", "the", "fly", "RK", "."], "h": {"id": "C1335620", "name": "C1335620#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1384522", "name": "C1384522#ent", "pos": [24, 25]}}
{"token": ["The", "patient", "was", "admitted", "because", "of", "severe", "C0018801#ent", "<e1>", "shock", ",", "and", "severe", "C0011615#ent", "<e2>", "seen", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "C1705637#ent", "<e1>", "association", "with", "gp130", "and", "LIFR", "is", "C0669365#ent", "<e2>", "and", "independent", "of", "Y118", "and", "Y115", ",", "respectively", "."], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["Co-expression", "of", "C1705637#ent", "<e1>", "and", "PI3K", "a", "C0669365#ent", "<e2>", "activated", "form", "of", "Lck", "in", "COS7", "cells", "demonstrated", "the", "carboxyl-terminal", "SH2", "domain", "PI3K", "inducibly", "associate", "with", "the", "full-length", "SHP-1", "protein", "."], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [7, 8]}}
{"token": ["C0014518#ent", "<e1>", "TEN", ")", "is", "a", "rare", ",", "life", "threatening", "C0013227#ent", "<e2>", "induced", "cutaneous", "reaction", "reported", "by", "Lyell", "in", "1956", "."], "h": {"id": "C0014518", "name": "C0014518#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["Several", "cases", "of", "Stevens-Johnson", "syndrome", "SJS", ")", "and", "C0014518#ent", "<e1>", "TEN", ")", "have", "been", "described", "in", "patients", "taking", "this", "C0013227#ent", "<e2>", "."], "h": {"id": "C0014518", "name": "C0014518#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [19, 20]}}
{"token": ["This", "work", "describes", "the", "achievement", "of", "a", "knock-in", "model", "which", "reproduces", "a", "mutation", "of", "the", "C1421375#ent", "<e1>", "for", "a", "severe", "C2718078#ent", "<e2>", "humans", "(", "P248Q", "missense", "mutant", ")", "."], "h": {"id": "C1421375", "name": "C1421375#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2718078", "name": "C2718078#ent", "pos": [20, 21]}}
{"token": ["PGH2", "caused", "significantly", "greater", "contractions", "in", "aortic", "rings", "endothelium", "or", "in", "those", "with", "intact", "endothelium", "treated", "with", "NG-nitro-L-arginine", ",", "a", "C1373060#ent", "<e1>", "these", "contractions", "were", "inhibited", "by", "SQ", "29548", "not", "by", "C0038838#ent", "<e2>"], "h": {"id": "C1373060", "name": "C1373060#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [31, 32]}}
{"token": ["This", "DNA", "fragmentation", "inhibited", "by", "L-N-(I-iminoethyl)-ornithine", "(", "L-NIO", ")", ",", "a", "C1373060#ent", "<e1>", "but", "not", "by", "C0038838#ent", "<e2>", "SOD", ")", "."], "h": {"id": "C1373060", "name": "C1373060#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [16, 17]}}
{"token": ["Also", ",", "both", "compounds", "rapidly", "decreased", "basal", "Ca(2", "+", ")", "levels", "in", "resting", "cells", "led", "to", "a", "rapid", "decline", "of", "the", "C0001477#ent", "<e1>", "elevations", "evoked", "by", "C1333574#ent", "<e2>", "or", "PAF", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [26, 27]}}
{"token": ["Methyl", "beta-cyclodextrin", "no", "effect", "C0001477#ent", "<e1>", "depletion", "by", "the", "G", "protein-coupled", "agonists", "platelet-activating", "factor", "or", "C1333574#ent", "<e2>", ",", "but", "abolished", "agonist-stimulated", "Ca(2", "+", ")", "entry", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [15, 16]}}
{"token": ["In", "these", "cells", ",", "the", "degradation", "of", "the", "internalized", "insulin", "is", "initiated", "by", "a", "110", "kDa", ",", "C3538753#ent", "<e1>", "as", "the", "C0021669#ent", "<e2>"], "h": {"id": "C3538753", "name": "C3538753#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0021669", "name": "C0021669#ent", "pos": [21, 22]}}
{"token": ["We", "investigated", "role", "of", "nitric", "oxide", "NO", ")", ",", "C0356622#ent", "<e1>", "(", "PG", ")", "and", "C1421249#ent", "<e2>", "vascular", "endothelial", "growth", "factor", "increase", "in", "vascular", "permeability", "mouse", "skin"], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [15, 16]}}
{"token": ["The", "virus-induced", "C1706544#ent", "<e1>", "up-regulation", "was", "dependent", "on", "protein", "kinase", "C", "A", ",", "PI3K", "and", "C1120843#ent", "<e2>"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [15, 16]}}
{"token": ["These", "results", "provide", "further", "evidence", "for", "our", "previous", "conclusion", "that", "C0041261#ent", "<e1>", "somehow", "involved", "in", "repression", "of", "this", "C0029073#ent", "<e2>", "."], "h": {"id": "C0041261", "name": "C0041261#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [18, 19]}}
{"token": ["Activities", "of", "the", "following", "enzymes", "in", "cultured", "fibroblasts", "from", "both", "boys", "were", "normal", ":", "pyruvate", "dehydrogenase", "pyruvate", "carboxylase", "C0031644#ent", "<e1>", "cytochrome", "oxidase", "reduced", "nicotinamide-adenine", "dinucleotide-cytochrome", "c", "reductase", "and", "C0027293#ent", "<e2>"], "h": {"id": "C0031644", "name": "C0031644#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0027293", "name": "C0027293#ent", "pos": [28, 29]}}
{"token": ["Most", "of", "the", "gene", "clusters", "aminosugar", "biosynthesis", "common", "features", ",", "as", "they", "contain", "genes", "encoding", "dehydratases", ",", "isomerases", ",", "C0002594#ent", "<e1>", ",", "methyltransferases", ",", "and", "C0085249#ent", "<e2>", "."], "h": {"id": "C0002594", "name": "C0002594#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [25, 26]}}
{"token": ["Expression", "of", "C0796355#ent", "<e1>", "mRNA", "in", "K562", "and", "CEM", "cells", "C3642298#ent", "<e2>", "mRNA", "in", "CEM", "cells", "decreased", "after", "incubation", "of", "AS-PS-ODN", "."], "h": {"id": "C0796355", "name": "C0796355#ent", "pos": [2, 3]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3642298", "name": "C3642298#ent", "pos": [10, 11]}}
{"token": ["Adult", "female", "Wistar", "rats", "given", "a", "single", "intraperitoneal", "injection", "of", "either", "C0072953#ent", "<e1>", "(", "D2", "antagonist", ",", "SCH", "23390", "D1", "antagonist", "or", "the", "C1416886#ent", "<e2>", "(", "S", ")", "enantiomer", "SCH", "23388", "."], "h": {"id": "C0072953", "name": "C0072953#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416886", "name": "C1416886#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "nuclear", "translocation", "NFkappaB", "p52", "but", "neither", "that", "of", "C1417708#ent", "<e1>", "nor", "the", "phosphorylation", "of", "C1334290#ent", "<e2>", "and", "STAT6", "was", "reduced", "by", "fucoidan", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334290", "name": "C1334290#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "nuclear", "translocation", "C1417708#ent", "<e1>", "but", "neither", "that", "of", "NFkappaB", "p65", "nor", "the", "phosphorylation", "of", "C1334290#ent", "<e2>", "and", "STAT6", "was", "reduced", "by", "fucoidan", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334290", "name": "C1334290#ent", "pos": [16, 17]}}
{"token": ["Such", "disorders", "include", "gout", ",", "C0158303#ent", "<e1>", "rapidly", "destructive", "articular", "disease", "amyloid", "arthropathy", "hemophilic", "arthropathy", "primary", "synovial", "osteochondromatosis", "pigmented", "villonodular", "synovitis", "C0003892#ent", "<e2>", "and", "foreign-body", "synovitis"], "h": {"id": "C0158303", "name": "C0158303#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003892", "name": "C0003892#ent", "pos": [21, 22]}}
{"token": ["It", "may", "be", "associated", "with", "C0014130#ent", "<e1>", "as", "hermaphroditism", ",", "C0221406#ent", "<e2>", "Addison's", "disease", "obesity", "of", "unknown", "cause", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [10, 11]}}
{"token": ["We", "identified", "a", "novel", "binding", "motif", "present", "in", "C1422519#ent", "<e1>", "that", "is", "also", "found", "in", "its", "homolog", "C1422243#ent", "<e2>", "and", "other", "capping", "protein-associated", "proteins", "as", "CARMIL", "and", "CKIP-1", "."], "h": {"id": "C1422519", "name": "C1422519#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422243", "name": "C1422243#ent", "pos": [17, 18]}}
{"token": ["C0068897#ent", "<e1>", "(", "Gabitril", ",", "Sanofi", "Synlhelabo", ")", "new", "C0003299#ent", "<e2>", "used", "in", "add-on", "therapy", "in", "25", "children", "with", "resistant", "partial", "complex", "and", "secondary", "generalized", "seizures"], "h": {"id": "C0068897", "name": "C0068897#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [9, 10]}}
{"token": ["The", "C0010200#ent", "<e1>", "paroxysms", "of", "patients", "with", "C0010674#ent", "<e2>", "occasion", "neurological", "symptoms"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [7, 8]}}
{"token": ["The", "effect", "of", "positive", "expiratory", "pressure", "breathing", "alone", "and", "in", "combination", "with", "C0010200#ent", "<e1>", ",", "was", "investigated", "in", "eight", "patients", "with", "C0010674#ent", "<e2>"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [21, 22]}}
{"token": ["The", "periodic", "administration", "of", "positive", "airway", "pressure", "combined", "with", "directed", "C0010200#ent", "<e1>", "could", "aid", "mucus", "clearance", "in", "patients", "with", "C0010674#ent", "<e2>", "CF", ")", "and", "severe", "airway", "obstruction"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [19, 20]}}
{"token": ["Four", "C1417679#ent", "<e1>", "have", "been", "described", "in", "this", "C1334324#ent", "<e2>", "which", "has", "been", "named", "WNK", ",", "due", "to", "the", "absence", "of", "a", "key", "lysine", "in", "kinase", "subdomain", "II", "(", "with", "no", "K", "kinases", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334324", "name": "C1334324#ent", "pos": [8, 9]}}
{"token": ["These", "C1417679#ent", "<e1>", "include", "a", "previously", "unpublished", "member", "of", "the", "C1334324#ent", "<e2>", ",", "as", "well", "as", "2DL1", ",", "2DL4", ",", "3DL1", ",", "2DS4", ",", "3DL2", ",", "from", "centromere", "to", "telomere", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334324", "name": "C1334324#ent", "pos": [10, 11]}}
{"token": ["This", "paper", "summarizes", "our", "studies", "on", "proteoglycans", "and", "C3536869#ent", "<e1>", "in", "the", "hepatic", "fibrosis", "in", "C0036329#ent", "<e2>", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036329", "name": "C0036329#ent", "pos": [15, 16]}}
{"token": ["Most", "importantly", ",", "clubbing", "or", "C0263746#ent", "<e1>", "may", "provide", "the", "first", "clinical", "indication", "of", "a", "C0149516#ent", "<e2>", "an", "intrathoracic", "neoplasm"], "h": {"id": "C0263746", "name": "C0263746#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149516", "name": "C0149516#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "whether", "low-normal", "body", "lead", "burden", "(", "C1332672#ent", "<e1>", ")", "accelerates", "progressive", "C1565489#ent", "<e2>", "nondiabetic", "patients", "with", "chronic", "kidney", "diseases", "CKD", ")", "."], "h": {"id": "C1332672", "name": "C1332672#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [13, 14]}}
{"token": ["Quetiapine", ",", "a", "dibenzothiazepine", "derivative", ",", "is", "an", "atypical", "antipsychotic", ",", "C1516869#ent", "<e1>", "has", "a", "preclinical", "profile", "to", "C0009079#ent", "<e2>", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [18, 19]}}
{"token": ["However", ",", "studies", "examining", "the", "effects", "of", "C1414863#ent", "<e1>", "status", "on", "other", "types", "of", "immunity", "such", "as", "antiparasitic", "responses", "C0155877#ent", "<e2>", "suggested", "more", "C1414863#ent", "<e1>", "may", "not", "always", "be", "beneficial", "."], "h": {"id": "C0155877", "name": "C0155877#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [7, 8]}}
{"token": ["DGEs", "with", "EPA", "and", "C2348308#ent", "<e1>", "were", "easily", "oxidized", "by", "C0023837#ent", "<e2>", ",", "and", "the", "oxida-tion", "rate", "of", "DGEs", "comprised", "of", "C2348308#ent", "<e1>", "was", "BDD", ">", "CDD", ">", "SDD", "."], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2348308", "name": "C2348308#ent", "pos": [4, 5]}}
{"token": ["C0013570#ent", "<e1>", "highly", "conserved", "between", "MHV", "and", "IBV", ",", "potentially", "contains", "C1335440#ent", "<e2>", ",", "helicase", "and", "zinc", "finger", "domains"], "h": {"id": "C0013570", "name": "C0013570#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "C0058734#ent", "<e1>", "may", "be", "an", "effective", "agent", "for", "the", "treatment", "of", "C0235618#ent", "<e2>"], "h": {"id": "C0058734", "name": "C0058734#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0235618", "name": "C0235618#ent", "pos": [15, 16]}}
{"token": ["Like", "normal", "C1704816#ent", "<e1>", ",", "SF", "C1704816#ent", "<e1>", "contains", "the", "signal", "peptide", "the", "C1709708#ent", "<e1>", ",", "the", "heparin-binding", "domain", "the", "first", "two", "conservative", "disulfide", "loops", "the", "EGF", "unit", "."], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1709708", "name": "C1709708#ent", "pos": [13, 14]}}
{"token": ["The", "resistant", "cells", "cross-resistance", "to", "a", "number", "of", "other", "agents", ",", "including", "adriamycin", ",", "C0002062#ent", "<e1>", "melphalan", ",", "and", "C0687700#ent", "<e2>", "."], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0687700", "name": "C0687700#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "examine", "whether", "circulating", "Ang-1", "and/or", "C0540511#ent", "<e1>", "independently", "predict", "mortality", "in", "a", "cohort", "of", "C0010340#ent", "<e2>", "patients", "."], "h": {"id": "C0540511", "name": "C0540511#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010340", "name": "C0010340#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "SS-56", "represents", "a", "new", "member", "of", "the", "C1420041#ent", "<e1>", "family", "of", "C1413096#ent", "<e2>", "and", "could", "become", "an", "additional", "and", "important", "diagnostic", "marker", "C1420041#ent", "<e1>", "and", "SLE", "."], "h": {"id": "C1420041", "name": "C1420041#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [13, 14]}}
{"token": ["The", "studies", "showed", "differences", "in", "the", "C0078839#ent", "<e1>", "pattern", "between", "C1705396#ent", "<e2>", "derived", "from", "normal", "subjects", "nTHP", ")", "and", "from", "stone", "patients", "(", "pTHP", ")", "."], "h": {"id": "C0078839", "name": "C0078839#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705396", "name": "C1705396#ent", "pos": [10, 11]}}
{"token": ["TF-3", "and", "other", "C0071649#ent", "<e1>", "inhibited", "strongly", "the", "activities", "of", "xanthine", "oxidase", "C0033551#ent", "<e2>", ",", "EGF-receptor", "tyrosine", "kinase", "protein", "kinase", "C.", "results", "suggest", "that", "TF-3", "and", "other", "C0071649#ent", "<e1>", "exert", "their", "cancer", "chemoprevention", "suppressing", "tumor", "promotion", "inflammation", "by", "blocking", "signal", "transduction"], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0071649", "name": "C0071649#ent", "pos": [3, 4]}}
{"token": ["Chronic", "administration", "captopril", ",", "an", "angiotensin", "I", "enzyme", "inhibitor", "in", "C3887654#ent", "<e1>", "rats", "substantially", "attenuated", "development", "of", "C0178664#ent", "<e2>", "affecting", "PGC", "in", "earlier", "stages", "."], "h": {"id": "C3887654", "name": "C3887654#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [17, 18]}}
{"token": ["Co-expression", "of", "Hsp90", "enhanced", "PDK1-Src", "complex", "formation", "and", "led", "to", "further", "increased", "C1418440#ent", "<e1>", "activity", "toward", "C0812228#ent", "<e2>", "and", "SGK", "."], "h": {"id": "C1418440", "name": "C1418440#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [16, 17]}}
{"token": ["Nonetheless", ",", "the", "MET", "receptor", "cleaved", "in", "stress", "conditions", "by", "C0534519#ent", "<e1>", "within", "its", "intracellular", "region", "generating", "a", "40kDa", "fragment", ",", "C1826761#ent", "<e2>", "MET", ",", "with", "pro-apoptotic", "properties", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1826761", "name": "C1826761#ent", "pos": [21, 22]}}
{"token": ["The", "model", "used", "highlights", "the", "activity", "of", "the", "C0037766#ent", "<e1>", "that", "act", "on", "C0152163#ent", "<e2>", "at", "doses", "which", "per", "se", "do", "not", "cause", "a", "marked", "delay", "in", "GE", "."], "h": {"id": "C0037766", "name": "C0037766#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0152163", "name": "C0152163#ent", "pos": [13, 14]}}
{"token": ["C3553538#ent", "<e1>", "diagnosed", "with", "this", "symptom", "complex", "of", "sensorineural", "hearing", "loss", "C4082299#ent", "<e2>"], "h": {"id": "C3553538", "name": "C3553538#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C4082299", "name": "C4082299#ent", "pos": [11, 12]}}
{"token": ["The", "C3553538#ent", "<e1>", "BVVL", ")", "is", "a", "rare", "neurological", "disorder", "by", "progressive", "C4082299#ent", "<e2>", "associated", "with", "sensorineural", "deafness"], "h": {"id": "C3553538", "name": "C3553538#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C4082299", "name": "C4082299#ent", "pos": [12, 13]}}
{"token": ["Significance", "of", "polymorphisms", "of", "the", "genes", "involved", "in", "estrogens", "biosynthesis", "CYP17", ",", "C3254086#ent", "<e1>", ")", "and", "metabolism", "(", "CYP1A1", ",", "C0298987#ent", "<e2>", ",", "COMT", ")", "in", "modulating", "the", "susceptibility", "to", "breast", "cancer", "reviewed", "."], "h": {"id": "C3254086", "name": "C3254086#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0298987", "name": "C0298987#ent", "pos": [20, 21]}}
{"token": ["The", "downregulated", "GR", "and", "Bcl-2", "together", "with", "the", "upregulated", "C3539767#ent", "<e1>", "level", "in", "DP", "cells", "the", "significance", "of", "intrathymic", "C1367452#ent", "<e2>", "effects", "at", "this", "differentiation", "stage"], "h": {"id": "C3539767", "name": "C3539767#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [19, 20]}}
{"token": ["This", "report", "describes", "a", "patient", "with", "a", "long", "history", "C0238339#ent", "<e1>", "course", "was", "complicated", "by", "obstructive", "jaundice", "C0267917#ent", "<e2>", "and", "pancreatic", "insufficiency"], "h": {"id": "C0238339", "name": "C0238339#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0267917", "name": "C0267917#ent", "pos": [17, 18]}}
{"token": ["Six", "C0341703#ent", "<e1>", "have", "been", "previously", "identified", ":", "C1424667#ent", "<e2>", ",", "SSA2", ",", "SPA2", ",", "KNS1", ",", "DPS1/APS", "and", "SDC25", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1424667", "name": "C1424667#ent", "pos": [8, 9]}}
{"token": ["2", ")", "The", "efficacy", "of", "C0031381#ent", "<e1>", "is", "considerably", "greater", "than", "that", "of", "less-chlorinated", "phenols", "and", "C0031428#ent", "<e2>", "."], "h": {"id": "C0031381", "name": "C0031381#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [16, 17]}}
{"token": ["C0005859#ent", "<e1>", "administration", "produced", "decreased", "body", "weight", "gain", "acute", "leukocytopenia", "delayed", "elevation", "in", "blood", "nitrogen", "levels", "C0746102#ent", "<e2>", "kidney", "disease", "and", "alopecia", "."], "h": {"id": "C0005859", "name": "C0005859#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0746102", "name": "C0746102#ent", "pos": [16, 17]}}
{"token": ["Three", "protease-activated", "receptors", "C0032405#ent", "<e1>", ")", "for", "thrombin", "--", "PAR1", ",", "PAR3", ",", "and", "C3540804#ent", "<e2>", "--", "are", "now", "known", "."], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540804", "name": "C3540804#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "the", "restricted", "expression", "of", "C1421828#ent", "<e1>", "in", "structures", "affected", "in", "C2699751#ent", "<e2>", "suggests", "a", "role", "for", "this", "putative", "regulator", "of", "gene", "expression", "aspects", "of", "the", "C2699751#ent", "<e2>", "phenotype", "."], "h": {"id": "C1421828", "name": "C1421828#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2699751", "name": "C2699751#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "was", "to", "compare", "the", "effects", "of", "two", "C0037506#ent", "<e1>", "toothpaste", "formulations", "with", "and", "without", "C0005304#ent", "<e2>", "on", "human", "oral", "mucosa", "in", "vivo"], "h": {"id": "C0037506", "name": "C0037506#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005304", "name": "C0005304#ent", "pos": [16, 17]}}
{"token": ["Various", "C0075233#ent", "<e1>", "promoter", "constructs", "were", "used", "to", "identify", "the", "area", "associated", "with", "C0256103#ent", "<e2>", "and", "PKC", "inhibition", "."], "h": {"id": "C0075233", "name": "C0075233#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [13, 14]}}
{"token": ["Absent", "enzyme", "activity", "hypoxanthine-guanine-phosphoribosyl", "transferase", "erythrocytes", "was", "demonstrated", "in", "the", "blood", "from", "a", "21-year-old", "man", "with", "C0034372#ent", "<e1>", "choreoathetosis", ",", "oligophrenia", ",", "and", "C0740394#ent", "<e2>", "which", "developed", "after", "birth", "."], "h": {"id": "C0034372", "name": "C0034372#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0740394", "name": "C0740394#ent", "pos": [23, 24]}}
{"token": ["This", "activity", "was", "mirrored", "in", "vivo", "levels", "of", "C0051124#ent", "<e1>", "significantly", "decreased", "in", "rabbits", "administered", "C0020223#ent", "<e2>", "(", "10", "mg/kg/day", "for", "seven", "days", ")", "whereas", "hepatic", "xanthine", "oxidase", "activity", "unaltered", "by", "C0020223#ent", "<e2>", "treatment", "."], "h": {"id": "C0051124", "name": "C0051124#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [15, 16]}}
{"token": ["Gram-negative", "bacilli", "isolated", "more", "frequently", "from", "the", "tracheal", "aspirates", "of", "patients", "with", "C1535939#ent", "<e1>", "who", "were", "receiving", "antacids", "or", "C0019593#ent", "<e2>"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [19, 20]}}
{"token": ["Maximal", "deficit", "obtained", "on", "tests", "conducted", "on", "C1366618#ent", "<e1>", "but", "not", "on", "C1419040#ent", "<e2>", "."], "h": {"id": "C1366618", "name": "C1366618#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419040", "name": "C1419040#ent", "pos": [12, 13]}}
{"token": ["Millimolar", "concentrations", "of", "tervalent", "manganese", "pyrophosphate", "can", "partially", "activate", "C0068800#ent", "<e1>", "has", "been", "inactivated", "with", "NADH", "and", "C2985256#ent", "<e2>", "."], "h": {"id": "C0068800", "name": "C0068800#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [17, 18]}}
{"token": ["It", "has", "also", "been", "shown", "that", "Chlorella", "vulgaris", "form", "an", "inactivated", "C0068800#ent", "<e1>", "is", "an", "C2985256#ent", "<e2>", "complex", "."], "h": {"id": "C0068800", "name": "C0068800#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [15, 16]}}
{"token": ["In", "this", "paper", "we", "discuss", "recently", "discovered", "role", "of", "C0025543#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0162628#ent", "<e2>", "including", "psoriasis", "."], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [15, 16]}}
{"token": ["Citrullinaemia", "(", "C1825092#ent", "<e1>", ")", "is", "an", "autosomal", "recessive", "disease", "by", "deficiency", "of", "C3888272#ent", "<e2>", "ASS", ")", "."], "h": {"id": "C1825092", "name": "C1825092#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3888272", "name": "C3888272#ent", "pos": [13, 14]}}
{"token": ["Most", "patients", "with", "C0340543#ent", "<e1>", "defects", "in", "the", "gene", "for", "C1332431#ent", "<e2>", "BMPR2", ")", ",", "a", "member", "of", "the", "transforming", "growth", "factor", "beta", "TGF-beta", ")", "superfamily", "of", "receptors", "."], "h": {"id": "C0340543", "name": "C0340543#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332431", "name": "C1332431#ent", "pos": [10, 11]}}
{"token": ["Aspergillosis", "and", "C0006849#ent", "<e1>", "are", "ranked", "among", "the", "most", "common", "C0009450#ent", "<e2>", "birds", "of", "."], "h": {"id": "C0006849", "name": "C0006849#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [10, 11]}}
{"token": ["Despite", "C1692886#ent", "<e1>", "increasingly", "being", "reported", "in", "elderly", "patients", "with", "C0011849#ent", "<e2>", "or", "alcoholism", ",", "reported", "cases", "of", "spontaneous", "bacterial", "arthritis", "cirrhotic", "patients", "are", "extremely", "rare", "."], "h": {"id": "C1692886", "name": "C1692886#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}}
{"token": ["We", "also", "show", "that", "p53", "up-regulates", "the", "C1431671#ent", "<e1>", "activates", "the", "C0248813#ent", "<e2>", "JNK", ")", "pathway", "to", "drive", "apoptosis", "."], "h": {"id": "C1431671", "name": "C1431671#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [11, 12]}}
{"token": ["These", "patients", "were", "affected", "by", "amyotrophic", "lateral", "sclerosis", "bulbar", "onset", "sensitive", "C0442874#ent", "<e1>", "of", "Thevenard", "type", ",", "C0026896#ent", "<e2>", "and", "limb-girdle", "muscular", "dystrophy", "respectively", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [17, 18]}}
{"token": ["Finally", ",", "in", "vitro", "incubation", "with", "purified", "C3539645#ent", "<e1>", "indicated", "that", "C0025598#ent", "<e2>", "had", "no", "direct", "effect", "on", "C3539645#ent", "<e1>", "activity", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [11, 12]}}
{"token": ["Colonic", "C1422630#ent", "<e1>", "activity", "and", "BrdUrd", "labeling", "index", "the", "groups", "of", "rats", "treated", "with", "C2698738#ent", "<e2>", "and", "KYN-54", "at", "both", "doses", "were", "slightly", "lower", "than", "those", "treated", "with", "C2698738#ent", "<e2>", "alone", "."], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2698738", "name": "C2698738#ent", "pos": [14, 15]}}
{"token": ["No", "evidence", "was", "found", "for", "induction", "of", "the", "C0046494#ent", "<e1>", "its", "kinase", "by", "C0009003#ent", "<e2>"], "h": {"id": "C0046494", "name": "C0046494#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009003", "name": "C0009003#ent", "pos": [13, 14]}}
{"token": ["Stress-", "and", "pain-related", "stimuli", "cause", "a", "release", "of", "vasopressin", "(", "C2698414#ent", "<e1>", ")", "and", "oxytocin", "(", "OT", ")", "into", "the", "cerebrospinal", "fluid", "C3889436#ent", "<e2>", ")", "and", "extracellular", "fluid", "the", "brain", "in", "various", "animal", "species"], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [22, 23]}}
{"token": ["The", "development", "of", "AA", "was", "associated", "with", "inhibition", "of", "the", "C0111840#ent", "<e1>", "the", "liver", "and", "C0017837#ent", "<e2>"], "h": {"id": "C0111840", "name": "C0111840#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [15, 16]}}
{"token": ["AIDS", "patients", "(", "n", "=", "215", ")", "with", "moderate", "to", "severe", "P.", "carinii", "C1535939#ent", "<e1>", "were", "enrolled", "in", "a", "double-blind", "study", "C0085176#ent", "<e2>", "leucovorin", "versus", "trimethoprim-sulfamethoxazole", "(", "TMP-SMZ", ")", "for", "21", "days", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0085176", "name": "C0085176#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "C0064368#ent", "<e1>", "knockdown", "prevented", "processing", "of", "the", "C0291573#ent", "<e2>", "of", "the", "apoptosis", "cascade", "by", "the", "erucylphosphocholine", "congener", ",", "erucylphospho-N", ",", "N", ",", "N-trimethylammonium", "."], "h": {"id": "C0064368", "name": "C0064368#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [10, 11]}}
{"token": ["The", "denser", "components", "localized", "with", "the", "mitochondria", "but", "were", "distinct", "from", "C3899480#ent", "<e1>", "whereas", "the", "activity", "of", "C0010760#ent", "<e2>", "during", "HL-60", "cell", "maturation", ",", "that", "of", "this", "cytochrome", "b", "markedly", "increased", "."], "h": {"id": "C3899480", "name": "C3899480#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010760", "name": "C0010760#ent", "pos": [17, 18]}}
{"token": ["C1522575#ent", "<e1>", "VEGF", ")", ",", "monocyte", "chemoattractant", "protein-1", "MCP-1", ")", ",", "and", "interleukin", "8", "C1705592#ent", "<e2>", ")", "in", "GCF", "were", "analyzed", "by", "enzyme-linked", "immunosorbent", "assay"], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [14, 15]}}
{"token": ["The", "relevance", "of", "this", "work", "is", "highlighted", "by", "the", "recent", "finding", "of", "a", "mutation", "in", "the", "C1414919#ent", "<e1>", "a", "family", "with", "childhood", "absence", "C0036572#ent", "<e2>", "."], "h": {"id": "C1414919", "name": "C1414919#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [23, 24]}}
{"token": ["Our", "data", "suggest", "a", "direct", "role", "for", "C1708001#ent", "<e1>", "in", "DNA", "processing", "consistent", "with", "current", "view", "that", "FA", "proteins", "coordinate", "C1333237#ent", "<e2>", "stalled", "replication", "forks", "."], "h": {"id": "C1708001", "name": "C1708001#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [20, 21]}}
{"token": ["C0029001#ent", "<e1>", "(", "river", "blindness", "is", "a", "major", "C0747256#ent", "<e2>", "humans", "in", "sub-Saharan", "Africa", "by", "the", "microfilarial", "stage", "the", "nematode", "Onchocerca", "volvulus"], "h": {"id": "C0029001", "name": "C0029001#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [8, 9]}}
{"token": ["Onchocerciasis", "(", "C0029001#ent", "<e1>", "is", "a", "major", "C0747256#ent", "<e2>", "humans", "in", "sub-Saharan", "Africa", "by", "the", "microfilarial", "stage", "the", "nematode", "Onchocerca", "volvulus"], "h": {"id": "C0029001", "name": "C0029001#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [7, 8]}}
{"token": ["The", "expression", "of", "a", "very", "early", "activation", "antigen", "C3540471#ent", "<e1>", ",", "was", "not", "detected", "on", "C1705831#ent", "<e2>", ")", "DETCs", ",", "whereas", "C3540471#ent", "<e1>", "was", "expressed", "on", "ZAP-70(+/-", ")", "DETCs", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705831", "name": "C1705831#ent", "pos": [15, 16]}}
{"token": ["Normal", "subjects", "a", "mean", "V(imax", ")", "and", "C0268696#ent", "<e1>", "much", "higher", "than", "those", "of", "patients", "with", "C1412502#ent", "<e2>", "."], "h": {"id": "C0268696", "name": "C0268696#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412502", "name": "C1412502#ent", "pos": [16, 17]}}
{"token": ["Nerve", "growth", "C1366571#ent", "<e1>", "changes", ",", "such", "as", "the", "induction", "of", "C0029282#ent", "<e2>", "the", "generation", "of", "neurites", ",", "were", "inhibited", ",", "but", "only", "minimally", ",", "in", "dexamethasone-treated", "cells", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [11, 12]}}
{"token": ["As", "protein", "synthesis", "required", "for", "C0010656#ent", "<e1>", "and", "apoptosis", "activation", ",", "DEX-induced", "C1705401#ent", "<e2>", "nuclear", "translocation", "necessary", "for", "apoptosis", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [12, 13]}}
{"token": ["The", "results", "indicate", "that", "onset", "of", "spermatogenic", "activity", "dependent", "on", "FSH", "(", "or", "C1450798#ent", "<e1>", ",", "but", "not", "on", "the", "C3536949#ent", "<e2>", "."], "h": {"id": "C1450798", "name": "C1450798#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [20, 21]}}
{"token": ["In", "preliminary", "experiments", ",", "norflurazon", ",", "an", "inhibitor", "of", "C0071009#ent", "<e1>", "was", "used", "to", "prevent", "phytoene", "being", "further", "C0025517#ent", "<e2>", "to", "carotenoids", "."], "h": {"id": "C0071009", "name": "C0071009#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [18, 19]}}
{"token": ["C0000402#ent", "<e1>", "HMGA", ")", "is", "a", "competitive", "inhibitor", "of", "C1415615#ent", "<e2>", "HMGCoAR", ")", "and", "strongly", "reduces", "cholesterol", "biosynthesis", "in", "vitro", "in", "vivo"], "h": {"id": "C0000402", "name": "C0000402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415615", "name": "C1415615#ent", "pos": [9, 10]}}
{"token": ["Diarrhoea", "is", "an", "important", "feature", "of", "the", "C0024586#ent", "<e1>", "and", "various", "C0035064#ent", "<e2>", "which", "may", "be", "released", "from", "carcinoid", "tumours", "been", "considered", "to", "contribute", "pathophysiologically", "."], "h": {"id": "C0024586", "name": "C0024586#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["The", "objective", "of", "our", "study", "was", "to", "estimate", "the", "impact", "of", "C3899278#ent", "<e1>", "C0003873#ent", "<e2>", ")", "on", "psychological", "distress", "comparing", "patients", "with", "C0003873#ent", "<e2>", "and", "matched", "controls"], "h": {"id": "C3899278", "name": "C3899278#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}}
{"token": ["The", "results", "support", "the", "hypothesis", "that", "C0053105#ent", "<e1>", "can", "be", "C0025517#ent", "<e2>", "extra-hepatically", "by", "N-demethylation", "reaction", "catalyzed", "by", "peroxidases", "."], "h": {"id": "C0053105", "name": "C0053105#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [10, 11]}}
{"token": ["Cysteine-rich", "61", "Cyr61", ")", ",", "from", "the", "C3890221#ent", "<e1>", "gene", "family", "is", "a", "secreted", "and", "C1824983#ent", "<e2>", "which", "is", "involved", "in", "many", "cellular", "activities", "as", "growth", "and", "differentiation", "."], "h": {"id": "C3890221", "name": "C3890221#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824983", "name": "C1824983#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "we", "conclude", "that", "the", "occurrence", "of", "C0341858#ent", "<e1>", "is", "correlated", "to", "C1704467#ent", "<e2>", "expression", "regulated", "by", "estrogen", "and", "ER", "rather", "than", "genetic", "mutation"], "h": {"id": "C0341858", "name": "C0341858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [13, 14]}}
{"token": ["A", "72-year-old", "man", "with", "long-standing", "C0857112#ent", "<e1>", "refractory", "to", "C0733365#ent", "<e2>", "ophthalmic", "solution", "therapy", "many", "years", "."], "h": {"id": "C0857112", "name": "C0857112#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0733365", "name": "C0733365#ent", "pos": [9, 10]}}
{"token": ["This", "interferes", "with", "STAT-1", "and", "C2986464#ent", "<e1>", "thereby", "inhibiting", "TNF-alpha/IFN-gamma-mediated", "induction", "of", "HBD-2", "and", "C2984540#ent", "<e2>", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2984540", "name": "C2984540#ent", "pos": [14, 15]}}
{"token": ["Structural", "models", "been", "produced", "for", "three", "types", "of", "non-NMDA", "inotropic", "glutamate", "receptors", ":", "an", "AMPA", "receptor", "C1415287#ent", "<e1>", ",", "a", "kainate", "receptor", "GluR6", ";", "and", "a", "C0019139#ent", "<e2>", "goldfish", ",", "GFKAR", "alpha", "."], "h": {"id": "C1415287", "name": "C1415287#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [26, 27]}}
{"token": ["A", "crossover", "comparative", "study", "C0037567#ent", "<e1>", "clonazepam", "in", "the", "treatment", "of", "32", "adult", "C0014544#ent", "<e2>", "patients", "receiving", "multiple", "drug", "therapy", "described", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}}
{"token": ["To", "evaluate", "the", "efficacy", "or", "eventual", "side-effects", "of", "the", "association", "of", "lamotrigine", "and", "C0037567#ent", "<e1>", "the", "control", "of", "C0014544#ent", "<e2>"], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [18, 19]}}
{"token": ["A", "simple", "and", "efficient", "novel", "method", "for", "isolating", "picomole", "amounts", "of", "choline", "and", "C3653445#ent", "<e1>", "milliliter", "volumes", "of", "C0064411#ent", "<e2>", "been", "developed", "."], "h": {"id": "C3653445", "name": "C3653445#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0064411", "name": "C0064411#ent", "pos": [18, 19]}}
{"token": ["Genetic", "and", "expression", "analyses", "all", "five", "zebrafish", "lgi", "C1417679#ent", "<e1>", "revealed", "duplications", "of", "lgi1", "and", "C1425729#ent", "<e2>", ",", "each", "resulting", "in", "two", "paralogous", "gene", "copies", "mostly", "nonoverlapping", "expression", "patterns", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425729", "name": "C1425729#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", "the", "increased", "C2732002#ent", "<e1>", "levels", "in", "OC", "users", "depend", "on", "the", "C2732002#ent", "<e1>", "genotype", "and", "that", "high", "C0812385#ent", "<e1>", "concentrations", "predict", "very", "high", "levels", "of", "FVIIa", "and", "FVIIc", "."], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [21, 22]}}
{"token": ["These", "data", "indicate", "that", "the", "p50", "subunit", "NF-kappa", "B", "involved", "in", "the", "regulation", "of", "C3538699#ent", "<e1>", "expression", "and", "that", "C0812287#ent", "<e2>", "down-regulates", "MHC", "Class", "I", "gene", "expression", "through", "suppression", "of", "p50", "expression", "."], "h": {"id": "C3538699", "name": "C3538699#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812287", "name": "C0812287#ent", "pos": [19, 20]}}
{"token": ["The", "identification", "of", "C1335528#ent", "<e1>", "help", "to", "design", "C0010656#ent", "<e2>", "inhibitors", "."], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [8, 9]}}
{"token": ["C1413029#ent", "<e1>", "and", "membrane", "attack", "complex", "detected", "in", "the", "C0268731#ent", "<e2>", "despite", "the", "absence", "of", "C3", "."], "h": {"id": "C1413029", "name": "C1413029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [9, 10]}}
{"token": ["There", "was", "no", "significant", "correlation", "between", "the", "intensity", "of", "C3c", "or", "C1413029#ent", "<e1>", "deposition", "in", "C0268731#ent", "<e2>", "and", "the", "degree", "of", "glomerular", "sclerosis"], "h": {"id": "C1413029", "name": "C1413029#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [15, 16]}}
{"token": ["Similar", "results", "were", "obtained", "in", "mice", "in", "which", "C1419111#ent", "<e1>", "was", "inhibited", "via", "overexpression", "of", "the", "RAP", "gene", "liver", "by", "C1519598#ent", "<e2>"], "h": {"id": "C1419111", "name": "C1419111#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1519598", "name": "C1519598#ent", "pos": [20, 21]}}
{"token": ["High", "doses", "RA", "release", "C1333891#ent", "<e1>", "activity", "from", "C1709412#ent", "<e2>", ",", "but", "not", "from", "PLZF-RARalpha", "."], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709412", "name": "C1709412#ent", "pos": [8, 9]}}
{"token": ["BLASTX", "searches", "and", "phylogenetic", "analysis", "that", "five", "cDNAs", "belonged", "to", "four", "classes", "(", "C1621352#ent", "<e1>", ",", "Dnmt2", ",", "CMT", "and", "Dnmt3", ")", "of", "C1414121#ent", "<e2>"], "h": {"id": "C1621352", "name": "C1621352#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414121", "name": "C1414121#ent", "pos": [23, 24]}}
{"token": ["Cellulose", "acetate", "a", "1.2-micron", "pore", "size", "the", "best", "results", "for", "Cryptosporidium", "oocysts", "and", "C0600190#ent", "<e1>", "a", "3.0-micron", "pore", "size", "so", "for", "C0017536#ent", "<e2>"], "h": {"id": "C0600190", "name": "C0600190#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017536", "name": "C0017536#ent", "pos": [21, 22]}}
{"token": ["It", "thus", "appears", "that", "both", "primary", "and", "substituted", "C0772162#ent", "<e1>", "undergo", "one-electron", "oxidation", "by", "C1705397#ent", "<e2>", "."], "h": {"id": "C0772162", "name": "C0772162#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [14, 15]}}
{"token": ["Five", "cases", "of", "persistent", "hyperglycaemia", "requiring", "insulin", "therapy", "following", "C0030863#ent", "<e1>", "treatment", "for", "C0023290#ent", "<e2>", "being", "reported", "."], "h": {"id": "C0030863", "name": "C0030863#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [13, 14]}}
{"token": ["The", "activity", "of", "pentamidine-loaded", "nanoparticles", "was", "compared", "with", "that", "of", "free", "C0030863#ent", "<e1>", "in", "a", "BALB/c", "mice", "model", "of", "C0023290#ent", "<e2>", "induced", "by", "Leishmania", "infantum"], "h": {"id": "C0030863", "name": "C0030863#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [19, 20]}}
{"token": ["C0529793#ent", "<e1>", "is", "metabolized", "in", "the", "C0023899#ent", "<e2>", "through", "cytochrome", "P-450"], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}}
{"token": ["Macrophage", "inflammatory", "products", "tumor", "necrosis", "factor", "TNF", ")", "and", "interleukin-12/p40", "are", "implicated", "in", "demyelinating", "diseases", "as", "C1417325#ent", "<e1>", "MS", ")", ",", "Guillain-Barr\u00e9", "syndrome", "and", "animal", "models", "experimental", "autoimmune", "encephalomyelitis", "C0027813#ent", "<e2>", "."], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0027813", "name": "C0027813#ent", "pos": [29, 30]}}
{"token": ["C0024054#ent", "<e1>", "were", "stimulated", "with", "phytohemagglutinin", "(", "PHA", ")", "or", "C1522405#ent", "<e2>", "rIL-2", ")", "and", "further", "expanded", "in", "vitro", "IL-2-containing", "media", "."], "h": {"id": "C0024054", "name": "C0024054#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [10, 11]}}
{"token": ["Among", "these", "epilepsies", "and", "epileptic", "syndromes", "I", "detailed", "the", "clinical", "symptomatology", "and", "the", "clinical", "significance", "benign", "familial", "neonatal", "convulsions", ",", "C0270853#ent", "<e1>", "epilepsy", "with", "C0027066#ent", "<e2>", "absence", ",", "mesial", "temporal", "lobe", "epilepsy", "chronic", "progressive", "epilepsia", "partialis", "continua", "childhood", "."], "h": {"id": "C0270853", "name": "C0270853#ent", "pos": [20, 21]}, "relation": "has_manifestation", "t": {"id": "C0027066", "name": "C0027066#ent", "pos": [24, 25]}}
{"token": ["Relative", "to", "placebo", ",", "C0010592#ent", "<e1>", "associated", "with", "frequencies", "of", "C0085624#ent", "<e2>", "tearing", ",", "redness", ",", "itching", ",", "and", "headache", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085624", "name": "C0085624#ent", "pos": [10, 11]}}
{"token": ["C0080054#ent", "<e1>", "Cdk", ")", "inhibitor", "p21(Waf1/Cip1/Sdi1", ")", ",", "a", "C1415740#ent", "<e2>", "has", "a", "major", "role", "as", "tumor", "suppressor", "mediating", "G1/S", "arrest", "inhibition", "of", "Cdks", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [9, 10]}}
{"token": ["Southern", "blot", "analysis", "that", "the", "C0006698#ent", "<e1>", "likely", "encoded", "by", "a", "single", ",", "relatively", "large", "C0079429#ent", "<e2>", "."], "h": {"id": "C0006698", "name": "C0006698#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["It", "also", "induces", "detoxifying", "enzymes", "belonging", "to", "the", "C0017837#ent", "<e1>", "GSTs", ")", ",", "namely", "C3814418#ent", "<e2>", ",", "hGSTP1", ",", "hGSTA4", ",", "but", "not", "of", "hGSTT1", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3814418", "name": "C3814418#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "hepatic", "XOR", "and", "AOX", "were", "found", "to", "generate", "ROS", "in", "two", "ways", "from", "alcohol", "metabolism", "by", "C0030438#ent", "<e1>", "consumption", "and", "by", "the", "intrinsic", "NADH", "oxidase", "of", "both", "C1704669#ent", "<e2>", "and", "AOX", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704669", "name": "C1704669#ent", "pos": [29, 30]}}
{"token": ["Fibroblasts", "were", "damaged", "by", "the", "generation", "of", "oxygen", "metabolites", "the", "enzymatic", "oxidation", "of", "C0030438#ent", "<e1>", "by", "50", "munits", "of", "xanthine-oxidase", "(", "C1704669#ent", "<e2>", ")", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704669", "name": "C1704669#ent", "pos": [21, 22]}}
{"token": ["Peptidoglycan", "(", "PG", ")", "from", "Legionella", "pneumophila", "composed", "of", "muramic", "acid", "C0017718#ent", "<e1>", ",", "glutamic", "acid", "alanine", ",", "and", "C0011961#ent", "<e2>", "a", "molar", "ratio", "0.8:0.8:1.1:1.7:1", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011961", "name": "C0011961#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "the", "increases", "in", "C1414368#ent", "<e1>", "levels", "in", "these", "C0035242#ent", "<e2>", "be", "mainly", "caused", "by", "an", "imbalance", "of", "elastase/antielastase", "system", "the", "lung", "tissue", "the", "bloodstream", "."], "h": {"id": "C1414368", "name": "C1414368#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [12, 13]}}
{"token": ["Phenytoin", "selectively", "increased", "C1417708#ent", "<e1>", "target", "tissues", "and", "caused", "C0013949#ent", "<e2>", ",", "both", "of", "which", "were", "blocked", "by", "NF-kappaB", "antisense", "oligonucleotides", "not", "by", "sense", "and", "nonsense", "oligonucleotide", "controls"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013949", "name": "C0013949#ent", "pos": [9, 10]}}
{"token": ["Early", "glucose", "tolerance", "during", "first", "clinic", "visit", "could", "prevent", "some", "C0342257#ent", "<e1>", "complications", "in", "C0085207#ent", "<e2>", "among", "women", "with", "risk", "factors"], "h": {"id": "C0342257", "name": "C0342257#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "C1427594#ent", "<e1>", "acts", "as", "an", "endogenous", "neuroprotective", "factor", "C0007785#ent", "<e2>", "may", "therefore", "represent", "a", "target", "for", "the", "development", "of", "new", "treatments", "for", "stroke", "."], "h": {"id": "C1427594", "name": "C1427594#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [11, 12]}}
{"token": ["Micafungin", "holds", "promise", "as", "a", "first-line", "treatment", "for", "C0006840#ent", "<e1>", ",", "as", "well", "as", "prophylaxis", "against", "invasive", "C0026946#ent", "<e2>", "periods", "of", "neutropenia", "in", "high-risk", "patients", "."], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [17, 18]}}
{"token": ["C1366439#ent", "<e1>", "SHBG", ")", "and", "pregnancy", "zone", "protein", "PZP", ")", "are", "two", "highly", "C0072523#ent", "<e2>"], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072523", "name": "C0072523#ent", "pos": [13, 14]}}
{"token": ["These", "data", "strongly", "suggest", "that", "genetic", "factors", "other", "than", "HLA", "and", "C3150275#ent", "<e1>", "and/or", "environmental", "factors", "necessary", "for", "the", "expression", "of", "C0024141#ent", "<e2>", "and", "other", "immune", "abnormalities", "lupus", "families", "."], "h": {"id": "C3150275", "name": "C3150275#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [21, 22]}}
{"token": ["The", "N-terminal", "amino", "acid", "the", "C0534137#ent", "<e1>", "clofibrate-treated", "rats", "is", "methionine", "and", "alignment", "of", "the", "N-terminal", "segment", "of", "the", "P450DEHP", "with", "C0534137#ent", "<e1>", "that", "the", "first", "four", "C3539947#ent", "<e1>", "absent", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [27, 28]}}
{"token": ["N-Terminal", "sequencing", "these", "peptides", "yielded", "the", "amino", "acid", "sequences", "(", "for", "P450", "2B1", "and", "PYTEAV", "(", "for", "C0534137#ent", "<e1>", "that", "corresponded", "to", "C3539947#ent", "<e2>", "and", "P347-M365", "in", "P450s", "2B1", "and", "2B6", ",", "respectively", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [22, 23]}}
{"token": ["The", "present", "study", "suggested", "that", "motoneuron", "loss", "the", "C0011303#ent", "<e1>", "GBS", "and", "C2827560#ent", "<e2>", "is", "the", "consequence", "of", "the", "axonal", "pathology", "of", "the", "motoneuron", "axons", "."], "h": {"id": "C0011303", "name": "C0011303#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2827560", "name": "C2827560#ent", "pos": [12, 13]}}
{"token": ["GM1", "treatment", "but", "not", "C1522444#ent", "<e1>", "treatments", "caused", "significant", "sparing", "of", "substantia", "nigra", "pars", "compacta", "C1420276#ent", "<e2>", ")", "tyrosine", "hydroxylase", "neurons", "."], "h": {"id": "C1522444", "name": "C1522444#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [15, 16]}}
{"token": ["Multiple", "familial", "trichoepithelioma", "C1822742#ent", "<e1>", ")", "is", "an", "autosomal", "dominant", "C0037274#ent", "<e2>", "characterized", "by", "the", "presence", "of", "many", "small", "tumors", "on", "the", "face", "."], "h": {"id": "C1822742", "name": "C1822742#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [10, 11]}}
{"token": ["GDC", "10", "softs", "and", "soft", "C0175693#ent", "<e1>", "were", "used", "for", "the", "first", "ten", "C0751003#ent", "<e2>", ",", "and", "Ultrasofts", "were", "used", "for", "the", "last", "eleven", "C0751003#ent", "<e2>", "."], "h": {"id": "C0175693", "name": "C0175693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [13, 14]}}
{"token": ["C0314719#ent", "<e1>", "symptoms", "are", "often", "associated", "with", "soft", "contact", "lens", "C1704894#ent", "<e2>", ")", "wear", "and", "may", "be", "affected", "by", "environmental", "conditions"], "h": {"id": "C0314719", "name": "C0314719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704894", "name": "C1704894#ent", "pos": [10, 11]}}
{"token": ["Significantly", "less", "conversion", "of", "testosterone", "to", "C2936882#ent", "<e1>", "occurred", "with", "C1419986#ent", "<e2>", "compared", "to", "control", "preincubation", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419986", "name": "C1419986#ent", "pos": [10, 11]}}
{"token": ["The", "initial", "differential", "diagnosis", "of", "red", "eye", "which", "includes", "iritis", ",", "C0281773#ent", "<e1>", "keratitis", "and", "C0010043#ent", "<e2>", "and", "rarer", "disorders", "must", "be", "reexamined", "."], "h": {"id": "C0281773", "name": "C0281773#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010043", "name": "C0010043#ent", "pos": [15, 16]}}
{"token": ["Twenty-four", "hours", "of", "cyclic", "strain", "increased", "H441", "C1704657#ent", "<e1>", ",", "Src", ",", "and", "C3849574#ent", "<e2>", "phosphorylation", "without", "affecting", "total", "C1704657#ent", "<e1>", ",", "Src", ",", "or", "ERK", "protein"], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [13, 14]}}
{"token": ["We", "therefore", "studied", "the", "effect", "of", "calcitonin", "on", "the", "tyrosine", "phosphorylation", "subcellular", "distribution", "of", "paxillin", ",", "HEF1", ",", "C1704657#ent", "<e1>", ",", "and", "Pyk2", ",", "a", "C3849574#ent", "<e2>", "in", "osteoclasts", "."], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [25, 26]}}
{"token": ["It", "has", "been", "shown", "that", "C1335634#ent", "<e1>", "is", "phosphorylated", "and", "activated", "by", "casein", "kinase", "C0752519#ent", "<e2>", "when", "both", "molecules", "are", "over-expressed", "in", "cultured", "cells"], "h": {"id": "C1335634", "name": "C1335634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0752519", "name": "C0752519#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", "when", "expressed", "in", "mammalian", "cells", "C1335634#ent", "<e1>", "associates", "with", "C0752519#ent", "<e2>", "CKIepsilon", ")", ",", "a", "crucial", "regulator", "of", "Wnt", "signaling"], "h": {"id": "C1335634", "name": "C1335634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752519", "name": "C0752519#ent", "pos": [12, 13]}}
{"token": ["Side", "effects", "as", "C3714552#ent", "<e1>", "urinary", "retention", "not", "observed", "in", "the", "C0700541#ent", "<e2>", "group", "."], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0700541", "name": "C0700541#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "there", "was", "a", "different", "effect", "of", "three", "hydroxamic", "acid-based", "inhibitors", "(", "C0215791#ent", "<e1>", ",", "compound", "1", "compound", "4", "towards", "TNF-alpha", "convertase", "compared", "to", "ACE", "C0171484#ent", "<e2>", "and", "alpha-secretase", "."], "h": {"id": "C0215791", "name": "C0215791#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0171484", "name": "C0171484#ent", "pos": [27, 28]}}
{"token": ["Clinical", "manifestations", "postnatal", "growth", "retardation", "C0014547#ent", "<e1>", ",", "microcephaly", ",", "behaviour", "disorder", "minor", "facial", "anomalies", "small", "sella", "turcica", "possible", "partial", "C3714796#ent", "<e2>", "and", "mental", "retardation"], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714796", "name": "C3714796#ent", "pos": [20, 21]}}
{"token": ["Blockade", "of", "C0694872#ent", "<e1>", "cell", "adhesion", "pancreatic", "islets", "the", "glucose-stimulated", "increases", "in", "intracellular", "C0001477#ent", "<e2>", "levels", "and", "insulin", "secretion", "suggesting", "that", "loss", "of", "E-cadherin", "in", "beta-cells", "is", "associated", "with", "impaired", "insulin", "secretion"], "h": {"id": "C0694872", "name": "C0694872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [13, 14]}}
{"token": ["A", "new", "study", "demonstrates", "that", "C1825781#ent", "<e1>", "protects", "intestinal", "epithelium", "TNF-alpha-induced", "apoptosis", ",", "abrogating", "C0021390#ent", "<e2>", "IBD", ")", "."], "h": {"id": "C1825781", "name": "C1825781#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [14, 15]}}
{"token": ["The", "results", "of", "these", "studies", "showed", "that", "TCR", "V", "gene", "in", "C0026769#ent", "<e1>", "brains", "may", "be", "restricted", "and", "in", "particular", "that", "C0242988#ent", "<e2>", "be", "preferentially", "rearranged", "in", "certain", "HLA", "haplotypes", "associated", "with", "susceptibility", "to", "C0026769#ent", "<e1>", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242988", "name": "C0242988#ent", "pos": [21, 22]}}
{"token": ["The", "main", "metabolites", "of", "proglumetacin", "maleate", ",", "C0033321#ent", "<e1>", "maleate", "and", "C0021246#ent", "<e2>", ",", "had", "effects", "similar", "to", "those", "of", "proglumetacin", "maleate", "on", "these", "four", "parameters", "on", "an", "equimolar", "dose", "basis", "."], "h": {"id": "C0033321", "name": "C0033321#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [11, 12]}}
{"token": ["This", "C1254351#ent", "<e1>", "also", "inhibited", "phosphorylation", "of", "exogenous", "protein", "catalyzed", "C1259877#ent", "<e2>", "isolated", "from", "rabbit", "kidney", "in", "vitro"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [10, 11]}}
{"token": ["PMR1", "is", "a", "C1416788#ent", "<e1>", "mRNA", "endonuclease", "initiates", "the", "destabilization", "of", "C1412332#ent", "<e2>", "mRNA", "."], "h": {"id": "C1416788", "name": "C1416788#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [11, 12]}}
{"token": ["C1412379#ent", "<e1>", "DNA", "synthesis", "also", "induced", "by", "isoproterenol", ",", "C0025681#ent", "<e2>", ",", "carbachol", "and", "pilocarpine", ",", "but", "not", "by", "serotonin", "or", "substance", "P."], "h": {"id": "C1412379", "name": "C1412379#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025681", "name": "C0025681#ent", "pos": [9, 10]}}
{"token": ["In", "cell", "lysates", "C1537626#ent", "<e1>", "shows", "moderate", "acyltransferase", "activity", "[(3)H]oleoyl-CoA", "but", "lacks", "acyl-CoA", ":", "C3539733#ent", "<e2>"], "h": {"id": "C1537626", "name": "C1537626#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539733", "name": "C3539733#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "we", "show", "that", "NAC", "treatment", "reduced", "caveolin-3", "protein", "and", "increased", "the", "sarcolemmal", "expression", "of", "C1413902#ent", "<e1>", "and", "the", "C1334043#ent", "<e2>", "utrophin", "."], "h": {"id": "C1413902", "name": "C1413902#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [20, 21]}}
{"token": ["Supravalvular", "aortic", "stenosis", "SVAS", ")", ",", "C1414542#ent", "<e1>", "MFS", ")", "and", "C0268338#ent", "<e2>", "EDS", "IV", "are", "three", "clinical", "entities", "by", "vascular", "abnormalities", "result", "from", "mutations", "of", "structural", "components", "of", "the", "extracellular", "matrix", "ECM", ")", "."], "h": {"id": "C1414542", "name": "C1414542#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268338", "name": "C0268338#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "studies", "of", "the", "effects", "of", "C0851183#ent", "<e1>", "on", "cell", "growth", "GH", "production", "in", "cultures", "maintained", "with", "T3-depleted", "conditions", "were", "carried", "out", "to", "detect", "putative", "C0243192#ent", "<e2>", "activity", "of", "C0851183#ent", "<e1>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0851183", "name": "C0851183#ent", "pos": [7, 8]}}
{"token": ["C1709801#ent", "<e1>", "is", "a", "member", "of", "a", "family", "of", "C1417679#ent", "<e2>", "involved", "in", "such", "functions", ",", "and", "C1709801#ent", "<e1>", "knockout", "mice", "increased", "sensitivity", "to", "ionizing", "radiation"], "h": {"id": "C1709801", "name": "C1709801#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}}
{"token": ["This", "study", "was", "carried", "out", "to", "assess", "the", "antisecretory", "effects", "and", "their", "possible", "changes", "over", "time", "of", "three", "different", "dose", "regimens", "of", "C0028978#ent", "<e1>", "that", "could", "be", "proposed", "for", "maintenance", "treatment", "C0013295#ent", "<e2>"], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [31, 32]}}
{"token": ["The", "aim", "of", "this", "study", "is", "to", "propose", "a", "regimen", "of", "C0028978#ent", "<e1>", "20", "mg", "twice", "weekly", "for", "the", "prevention", "of", "C0013295#ent", "<e2>", "DU", ")", "relapse", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [21, 22]}}
{"token": ["The", "FOXC2", "gene", "16q24", "is", "mutated", "in", "C0265345#ent", "<e1>", "LD", ")", ",", "in", "which", "C0042345#ent", "<e2>", "VV", ")", "are", "a", "common", "feature", "."], "h": {"id": "C0265345", "name": "C0265345#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [14, 15]}}
{"token": ["We", "find", "that", "the", "rate", "of", "wild-type", "centration", "depends", "equally", "on", "the", "C1417544#ent", "<e1>", "and", "the", "C2362546#ent", "<e2>", "."], "h": {"id": "C1417544", "name": "C1417544#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2362546", "name": "C2362546#ent", "pos": [16, 17]}}
{"token": ["Review", "of", "a", "5", "year", "clinical", "experience", "with", "the", "histamine", "H2-receptor", "antagonists", "metiamide", ",", "C0008783#ent", "<e1>", ",", "and", "ranitidine", "in", "20", "patients", "with", "C0043515#ent", "<e2>", "a", "treatment", "failure", "rate", "of", "50", "percent", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [23, 24]}}
{"token": ["infusion", "of", "C0008783#ent", "<e1>", "adequately", "inhibits", "gastric", "acid", "hypersecretion", "patients", "with", "C0043515#ent", "<e2>"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [11, 12]}}
{"token": ["A", "distinction", "is", "made", "between", "motor", "anomalies", "have", "a", "sensory", "basis", ",", "such", "as", "unsteady", "fixation", "in", "C0339696#ent", "<e1>", "and", "motor", "anomalies", "have", "a", "motor", "basis", "such", "as", "eccentric", "fixation", "C0750903#ent", "<e2>"], "h": {"id": "C0339696", "name": "C0339696#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0750903", "name": "C0750903#ent", "pos": [30, 31]}}
{"token": ["C0006684#ent", "<e1>", "nifedipine", ",", "D-600", ",", "and", "diltiazem", ")", "and", "C0304513#ent", "<e2>", "yohimbine", "and", "idazoxan", ")", "inhibit", "the", "B-HT", "920-induced", "pressor", "response", "in", "a", "dose-related", "manner", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304513", "name": "C0304513#ent", "pos": [10, 11]}}
{"token": ["iii", ")", "Co-expression", "studies", "of", "FIX", "and", "FX", "with", "C1428184#ent", "<e1>", "have", "shown", "that", "C1704977#ent", "<e2>", "activity", "is", "the", "rate-limiting", "step", "in", "the", "synthesis", "of", "biologically", "active", "vitamin", "K-dependent", "factors"], "h": {"id": "C1428184", "name": "C1428184#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1704977", "name": "C1704977#ent", "pos": [14, 15]}}
{"token": ["C1428184#ent", "<e1>", "C1704977#ent", "<e2>", ")", "is", "the", "molecular", "target", "coumarin", "anticoagulants", "mutations", "in", "C1704977#ent", "<e2>", "have", "been", "identified", "previously", "in", "individuals", "who", "required", "high", "warfarin", "doses", "."], "h": {"id": "C1428184", "name": "C1428184#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1704977", "name": "C1704977#ent", "pos": [2, 3]}}
{"token": ["The", "remaining", "downstream", "cleavages", "are", "effected", "by", "a", "C2717971#ent", "<e1>", "also", "within", "the", "N-terminal", "region", "of", "C1860991#ent", "<e2>", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1860991", "name": "C1860991#ent", "pos": [16, 17]}}
{"token": ["Hepatitis", "C", "virus", "HCV", ")", "encodes", "a", "polyprotein", "of", "which", "the", "majority", "of", "nonstructural", "proteins", "matured", "by", "the", "C2717971#ent", "<e1>", "in", "the", "N", "terminus", "of", "C1860991#ent", "<e2>", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1860991", "name": "C1860991#ent", "pos": [25, 26]}}
{"token": ["C0971122#ent", "<e1>", ",", "a", "newer", "C3537172#ent", "<e2>", "is", "being", "tested", "in", "large", "clinical", "trials"], "h": {"id": "C0971122", "name": "C0971122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537172", "name": "C3537172#ent", "pos": [5, 6]}}
{"token": ["The", "P2Y1", "receptor", "a", "G", "protein-coupled", "receptor", "C1428424#ent", "<e1>", ")", "and", "is", "stimulated", "by", "extracellular", "ADP", "and", "C1705556#ent", "<e2>", "."], "h": {"id": "C1428424", "name": "C1428424#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [17, 18]}}
{"token": ["C1423842#ent", "<e1>", "cell", "response", "involved", "in", "pathogenesis", "of", "autoimmune", "diseases", "such", "as", "C0011860#ent", "<e2>", "multiple", "sclerosis", "and", "Th2", "cell", "in", "pathogenesis", "of", "allergy", "and", "asthma", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}}
{"token": ["Several", "candidate", "gene", "polymorphisms", "been", "implicated", "in", "attention", "deficit", "hyperactivity", "disorder", "ADHD", ")", ",", "including", "C1416882#ent", "<e1>", "40bp", "VNTR", ",", "DRD4", "7+,", "DBH", "TaqI", "A2", "C0002085#ent", "<e2>", "."], "h": {"id": "C1416882", "name": "C1416882#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [25, 26]}}
{"token": ["Our", "results", "indicate", "that", "C1416882#ent", "<e1>", "is", "associated", "with", "ADHD", "in", "our", "sample", "but", "not", "with", "C0002085#ent", "<e2>", "of", "the", "VNTR", "polymorphism", "."], "h": {"id": "C1416882", "name": "C1416882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [16, 17]}}
{"token": ["C0526470#ent", "<e1>", "attenuated", "contractions", "to", "noradrenaline", ",", "and", "all", "of", "the", "C0006864#ent", "<e2>", "blocked", "contractions", "to", "KCl", "."], "h": {"id": "C0526470", "name": "C0526470#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006864", "name": "C0006864#ent", "pos": [11, 12]}}
{"token": ["The", "compounds", "investigated", "were", "anandamide", ",", "C0526470#ent", "<e1>", ",", "HU-308", ",", "WIN55,212", "-", "2", "and", "the", "endogenous", "C0006864#ent", "<e2>", ",", "N-arachidonyl-glycine", "."], "h": {"id": "C0526470", "name": "C0526470#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006864", "name": "C0006864#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "show", "that", "C0538727#ent", "<e1>", "produces", "significantly", "higher", "UF", "in", "long-day", "dwell", "in", "diabetic", "C0035078#ent", "<e2>", "patients", "on", "CCPD", "than", "in", "non-diabetic", "patients", "."], "h": {"id": "C0538727", "name": "C0538727#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "expression", "of", "C1707171#ent", "<e1>", "is", "not", "ubiquitous", "but", "cell", "type", "in", "C0812317#ent", "<e2>"], "h": {"id": "C1707171", "name": "C1707171#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812317", "name": "C0812317#ent", "pos": [13, 14]}}
{"token": ["Trypsin", "treatment", "of", "human", "erythrocytes", "releases", "a", "soluble", "C0061642#ent", "<e1>", "which", "binds", "to", "phytohemagglutinin", "and", "abolishes", "the", "erythroagglutinating", "and", "C1522428#ent", "<e2>", "this", "molecule", "."], "h": {"id": "C0061642", "name": "C0061642#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [19, 20]}}
{"token": ["No", "direct", "dependence", "has", "been", "revealed", "between", "the", "level", "of", "the", "C0061642#ent", "<e1>", "adjuvant", "action", "and", "their", "effect", "on", "the", "C1522428#ent", "<e2>", "production", "by", "macrophages", "."], "h": {"id": "C0061642", "name": "C0061642#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [20, 21]}}
{"token": ["The", "spectrum", "of", "kidney", "and", "C0042075#ent", "<e1>", "to", "purines", "comprises", "acute", "hyperuricosuric", "nephropathy", "chronic", "urate", "nephropathy", "C0451641#ent", "<e2>", "."], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [16, 17]}}
{"token": ["Fever", ",", "tachypnea", ",", "C3815497#ent", "<e1>", ",", "rhinorrhea", ",", "retractions", "of", "the", "C0008035#ent", "<e2>", "and", "wheezing", "were", "common", "findings", "."], "h": {"id": "C3815497", "name": "C3815497#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008035", "name": "C0008035#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "individuals", "with", "deficiencies", "of", "C0003280#ent", "<e1>", "homozygotes", "due", "to", "mutation", "of", "C0380964#ent", "<e2>", "prothrombin", "and", "individuals", "with", "multiple", "risk", "factors", "be", "defined", "as", "\"", "high", "risk", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0380964", "name": "C0380964#ent", "pos": [14, 15]}}
{"token": ["Results", "from", "these", "two", "studies", "show", "that", "C0009279#ent", "<e1>", "can", "cause", "a", "significant", "decrease", "in", "C0012373#ent", "<e2>", "absorption", "from", "both", "IR", "and", "SR", "dosage", "forms", "."], "h": {"id": "C0009279", "name": "C0009279#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012373", "name": "C0012373#ent", "pos": [15, 16]}}
{"token": ["C0031507#ent", "<e1>", "is", "metabolized", "to", "4'-HPPH", "by", "CYP2C9", "and", "C0960580#ent", "<e2>", "in", "which", "there", "are", "genetic", "polymorphisms"], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [9, 10]}}
{"token": ["Among", "the", "enzymes", "involved", "in", "AMP", "catabolism", ",", "C1412387#ent", "<e1>", "most", "active", "and", "C0001457#ent", "<e2>", "AMP", "5'-nucleotidase", "exhibit", "only", "20", "and", "10", "%", "of", "C1412387#ent", "<e1>", "activity", "respectively", "."], "h": {"id": "C1412387", "name": "C1412387#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [13, 14]}}
{"token": ["C0296958#ent", "<e1>", "diethyl", "7-(3,4,5-triphenyl-2-oxo-2,3-dihydro-imidazol-1-yl)heptane-", "phosphonate", ")", "and", "C0297049#ent", "<e2>", "2(-)[3-(4-chloro-3-trifluoromethylphenyl)ureido]-4-trifluoromethyl", "phenoxy]-4,5-dichlorobenzenesulfonic", "acid", ")", "inhibited", "CoA-IT", "activity", "(", "IC50", "values", "of", "9", "microM", "and", "6", "microM", ",", "respectively", ")", "."], "h": {"id": "C0296958", "name": "C0296958#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0297049", "name": "C0297049#ent", "pos": [7, 8]}}
{"token": ["To", "investigate", "how", "individual", "patients", "with", "C0029408#ent", "<e1>", "OA", ")", "respond", "to", "the", "non-steroidal", "anti-inflammatory", "drug", "NSAID", ")", "C0012091#ent", "<e2>", "and", "the", "centrally", "acting", "analgesic", "tramadol", "when", "individual", "on-demand", "dose", "titration", "is", "allowed", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [18, 19]}}
{"token": ["With", "the", "help", "of", "data", "from", "literature", "and", "own", "long-term", "observations", "the", "importance", "of", "the", "C0700623#ent", "<e1>", "(", "HLP", "type", "IIb-V", ")", "as", "precursors", "of", "the", "C0011860#ent", "<e2>", "is", "discussed", "."], "h": {"id": "C0700623", "name": "C0700623#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [26, 27]}}
{"token": ["Thirty", "patients", "were", "investigated", "with", "C0700623#ent", "<e1>", ",", "15", "patients", "with", "non-insulin", "dependent", "diabetes", "mellitus", "C0011860#ent", "<e2>", ")", "and", "15", "with", "primary", "hyperlipoproteinaemia"], "h": {"id": "C0700623", "name": "C0700623#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [15, 16]}}
{"token": ["Although", "the", "yeast", "genome", "does", "not", "encode", "bona", "fide", "protein", "tyrosine", "kinases", "C1333677#ent", "<e1>", "numerous", ",", "suggesting", "that", "besides", "C0287531#ent", "<e2>", "some", "Ser/Thr", "kinases", "are", "also", "committed", "to", "tyrosine", "phosphorylation", "Saccharomyces", "cerevisiae"], "h": {"id": "C1333677", "name": "C1333677#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0287531", "name": "C0287531#ent", "pos": [19, 20]}}
{"token": ["It", "consists", "of", "amiloride", ",", "adenosine", ",", "C0037533#ent", "<e1>", "dipyridamole", ",", "quinacrine", ",", "and", "C0040207#ent", "<e2>", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040207", "name": "C0040207#ent", "pos": [14, 15]}}
{"token": ["C1826658#ent", "<e1>", "has", "been", "shown", "recently", "to", "bind", "human", "Fc", "receptor", "C3536873#ent", "<e2>", "IgG", ";", "FcgammaR)I", "and", "mediate", "phagocytosis", "and", "signaling", "through", "the", "gamma-chain", "."], "h": {"id": "C1826658", "name": "C1826658#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536873", "name": "C3536873#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "effects", "of", "small", "sequence", "between", "the", "C1416652#ent", "<e1>", "promoter", "and", "other", "C3540490#ent", "<e2>", "promoters", "on", "transcription", "factor", "binding", "promoter", "activity"], "h": {"id": "C1416652", "name": "C1416652#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540490", "name": "C3540490#ent", "pos": [14, 15]}}
{"token": ["We", "find", "that", "static", "cortical", "actin", "resting", "T", "cells", "a", "restriction", "and", "that", "HIV", "utilizes", "the", "Galphai-dependent", "signaling", "from", "the", "chemokine", "coreceptor", "C1332823#ent", "<e1>", "to", "activate", "a", "cellular", "actin-depolymerizing", "factor", "C1413355#ent", "<e2>", ",", "to", "overcome", "this", "restriction", "."], "h": {"id": "C1332823", "name": "C1332823#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1413355", "name": "C1413355#ent", "pos": [30, 31]}}
{"token": ["To", "investigate", "the", "regulatory", "effect", "C1333714#ent", "<e1>", "on", "the", "growth", "of", "immortalized", "human", "gastric", "epithelial", "cell", "line", "C3539688#ent", "<e2>", ",", "as", "well", "as", "on", "the", "cell", "cycle-regulating", "elements", "cyclin", "D1", "CDK4", "."], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539688", "name": "C3539688#ent", "pos": [17, 18]}}
{"token": ["It", "is", "shown", "that", "C0009768#ent", "<e1>", "less", "than", "a", "1", "%", "effect", "on", "the", "clinical", "manifestation", "C0343723#ent", "<e2>", "on", "Taiwan", "and", "that", "it", "was", "equal", "between", "the", "C0343723#ent", "<e2>", "and", "control", "groups"], "h": {"id": "C0009768", "name": "C0009768#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0343723", "name": "C0343723#ent", "pos": [16, 17]}}
{"token": ["This", "SPA-based", "assay", "appears", "generic", "for", "the", "C0016790#ent", "<e1>", "readily", "adaptable", "for", "other", "C1333828#ent", "<e2>", "."], "h": {"id": "C0016790", "name": "C0016790#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [13, 14]}}
{"token": ["Two-week-old", "Japanese", "quails", "were", "infected", "intratracheally", "with", "six", "strains", "of", "Chlamydia", "psittaci", "isolated", "from", "C0032285#ent", "<e1>", "swine", "pneumonia", "goat", "abortion", ",", "sheep", "abortion", "kid", "enteritis", "and", "C0009774#ent", "<e2>", "respectively", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009774", "name": "C0009774#ent", "pos": [26, 27]}}
{"token": ["Streptococcus", "pneumoniae", "pneumococcus", "[", "Pnc", "]", ")", "is", "a", "causative", "agent", "many", "infectious", "diseases", "including", "C0032285#ent", "<e1>", ",", "septicemia", ",", "otitis", "media", "and", "C0009774#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0009774", "name": "C0009774#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "C1826332#ent", "<e1>", "mutations", "likely", "are", "not", "a", "cause", "of", "C1853723#ent", "<e2>", "."], "h": {"id": "C1826332", "name": "C1826332#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1853723", "name": "C1853723#ent", "pos": [12, 13]}}
{"token": ["Included", "are", "diseases", "of", "the", "lacrimal", "gland", "keratoconjunctivitis", "sicca", "immune-mediated", "diseases", "the", "conjunctiva", ",", "atopic", "blepharoconjunctivitis", "and", "C0005741#ent", "<e1>", "uveitis", "including", "lens-induced", "uveitis", "episcleritis", ",", "C0149507#ent", "<e2>", "and", "optic", "neuritis"], "h": {"id": "C0005741", "name": "C0005741#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0149507", "name": "C0149507#ent", "pos": [25, 26]}}
{"token": ["In", "conclusion", ",", "SAA", "appears", "to", "be", "an", "important", "mediator", "of", "the", "inflammatory", "process", "possibly", "contributing", "to", "the", "pool", "of", "IL-8", "produced", "in", "C1561643#ent", "<e1>", "which", "may", "play", "a", "role", "in", "C1456654#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1456654", "name": "C1456654#ent", "pos": [31, 32]}}
{"token": ["We", "performed", "whole", "genome", "case-control", "linkage", "disequilibrium", "C1414435#ent", "<e1>", ")", "mapping", "for", "rheumatoid", "arthritis", "C1417679#ent", "<e2>", "in", "Japanese", "subjects", "using", "single", "nucleotide", "polymorphisms", "SNPs", ")", "mainly", "discovered", "in", "gene-containing", "regions", "."], "h": {"id": "C1414435", "name": "C1414435#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}}
{"token": ["The", "entry", "of", "alpha-sarcin", ",", "horseradish", "peroxidase", "and", "C1334435#ent", "<e1>", "is", "greatly", "increased", "during", "the", "early", "stages", "C0042769#ent", "<e2>"], "h": {"id": "C1334435", "name": "C1334435#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [17, 18]}}
{"token": ["Video", "image", "analysis", "was", "found", "to", "be", "a", "sensitive", "method", "for", "rapid", "detection", "and", "semiquantitative", "measurement", "of", "C1334435#ent", "<e1>", "expression", "in", "baculovirus", "infected", "cells", "and", "for", "monitoring", "C0042769#ent", "<e2>", "larval", "tissues", "."], "h": {"id": "C1334435", "name": "C1334435#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [27, 28]}}
{"token": ["The", "dithiothreitol", "(", "DTT", ")", "assay", ",", "a", "quantitative", "measure", "of", "in", "vitro", "C0812281#ent", "<e1>", "formation", ",", "was", "correlated", "with", "C1418251#ent", "<e2>", "content", "and", "HO-1", "expression", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418251", "name": "C1418251#ent", "pos": [20, 21]}}
{"token": ["The", "C1415051#ent", "<e1>", "the", "main", "binding", "determinant", ":", "the", "C0034342#ent", "<e2>", "obligatory", ",", "whereas", "shifting", "of", "the", "amino", "group", "shortening", "of", "the", "peptide", "backbone", "decreased", "kcat./Km", "."], "h": {"id": "C1415051", "name": "C1415051#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [9, 10]}}
{"token": ["Interleukin-10", "(IL-10)-deficient", "mice", ",", "well", "characterized", "as", "an", "experimental", "model", "C0022104#ent", "<e1>", ",", "develop", "severe", "C0267375#ent", "<e2>", "of", "aberrant", "Th1", "responses", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0267375", "name": "C0267375#ent", "pos": [15, 16]}}
{"token": ["ULA1", "and", "C1421269#ent", "<e1>", "are", "related", "to", "the", "N-", "and", "C-terminal", "domains", "the", "C1452523#ent", "<e2>", "respectively", ",", "and", "together", "fulfil", "E1-like", "functions", "for", "RUB1", "activation", "."], "h": {"id": "C1421269", "name": "C1421269#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1452523", "name": "C1452523#ent", "pos": [13, 14]}}
{"token": ["The", "synthesis", "of", "C0033551#ent", "<e1>", "and", "lipoxygenase", "derivatives", "PMS-treated", "cells", "was", "inhibited", "by", "indomethacin", "and", "C0733397#ent", "<e2>", "respectively", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0733397", "name": "C0733397#ent", "pos": [15, 16]}}
{"token": ["However", "neither", "inhibitors", "of", "C0033551#ent", "<e1>", "(", "ibuprofen", ")", "nor", "lipoxygenases", "(", "C0733397#ent", "<e2>", ")", "reduced", "the", "ExoU", "toxicity", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0733397", "name": "C0733397#ent", "pos": [12, 13]}}
{"token": ["These", "effects", "were", "abolished", "by", "the", "phospholipase", "inhibitor", "p-bromophenacyl", "bromide", "or", "by", "concurrent", "inhibition", "of", "C0033551#ent", "<e1>", "and", "lipoxygenase", "by", "flurbiprofen", "plus", "nordihydroguaiaretic", "acid", "C0733397#ent", "<e2>", ")", ",", "respectively", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0733397", "name": "C0733397#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "the", "role", "of", "C1420202#ent", "<e1>", "in", "the", "brain", "after", "C0007785#ent", "<e2>", "we", "examined", "expression", "of", "C1420202#ent", "<e1>", "mRNA", "in", "the", "rat", "brain", "after", "middle", "cerebral", "artery", "occlusion", "which", "would", "reflect", "alteration", "of", "extracellular", "tonicity"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420202", "name": "C1420202#ent", "pos": [5, 6]}}
{"token": ["C0879392#ent", "<e1>", "to", "phosphorylate", "BAD", "include", "C0812228#ent", "<e2>", ",", "extracellular", "signal-regulated", "kinase/mitogen-activated", "protein", "kinase", "Erk/", "MAPK", ",", "Pim-1", "and", "Pim-2", "."], "h": {"id": "C0879392", "name": "C0879392#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [6, 7]}}
{"token": ["We", "report", "a", "patient", "who", "presented", "with", "C0270790#ent", "<e1>", "due", "to", "epidural", "abscess", "had", "C1541923#ent", "<e2>", "to", "Staphylococcus", "aureus", "septicemia"], "h": {"id": "C0270790", "name": "C0270790#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1541923", "name": "C1541923#ent", "pos": [14, 15]}}
{"token": ["To", "assess", "the", "possible", "correlation", "of", "basal", "cell", "proliferation", "C1415205#ent", "<e1>", "tumorigenicity", ",", "we", "evaluated", "the", "expression", "of", "proliferating", "cell", "nuclear", "antigen", "C1366837#ent", "<e2>", ")", "in", "both", "control", "and", "NMBA-treated", "rats", "."], "h": {"id": "C1415205", "name": "C1415205#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [22, 23]}}
{"token": ["The", "structural", "model", "C1413223#ent", "<e1>", "the", "conserved", "residues", "co-segregated", "with", "certain", "C0012634#ent", "<e2>"], "h": {"id": "C1413223", "name": "C1413223#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["C0001981#ent", "<e1>", "was", "slower", "than", "either", "suxamethonium", "or", "C0080352#ent", "<e2>", "in", "producing", "satisfactory", "conditions", "."], "h": {"id": "C0001981", "name": "C0001981#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080352", "name": "C0080352#ent", "pos": [8, 9]}}
{"token": ["In", "addition", "to", "[14C]methylcasein", ",", "the", "C1413108#ent", "<e1>", "hydrolyzed", "synthetic", "peptide", "substrates", "of", "C0960371#ent", "<e2>", "and", "chymotrypsin", "at", "pH", "7.75", "."], "h": {"id": "C1413108", "name": "C1413108#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [13, 14]}}
{"token": ["Interleukin", "21", "C3814041#ent", "<e1>", ")", "has", "recently", "been", "identified", "as", "a", "C1415740#ent", "<e2>", "cytokine", "that", "induces", "the", "proliferation", "of", "T", "cells", "B", "cells", "differentiation", "of", "natural", "killer", "cells"], "h": {"id": "C3814041", "name": "C3814041#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [11, 12]}}
{"token": ["No", "marked", "changes", "in", "activities", "of", "these", "three", "C0030016#ent", "<e1>", "were", "obtained", "for", "quail", "C0342895#ent", "<e2>", "the", "diet", "supplemented", "with", "DL-methionine", "alone", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [14, 15]}}
{"token": ["An", "extensive", "body", "of", "evidence", "has", "established", "that", "C3539565#ent", "<e1>", "protect", "women", "against", "dysmenorrhea", "and", "menorrhagia", ",", "menstrual", "cycle", "irregularities", "C0162316#ent", "<e2>", "ectopic", "pregnancy", "pelvic", "inflammatory", "disease", "ovarian", "cysts", "benign", "breast", "disease", "endometrial", "cancer", "and", "ovarian", "cancer"], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [20, 21]}}
{"token": ["Hypothesizing", "that", "synapse", "loss", "be", "greater", "in", "demented", "than", "non-demented", "C1332754#ent", "<e1>", "patients", ",", "we", "examined", "C1420554#ent", "<e2>", "concentrations", "in", "8", "cases", "of", "C1332754#ent", "<e1>", "(", "5", "demented", "and", "3", "nondemented", "cases", ")", "."], "h": {"id": "C1420554", "name": "C1420554#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [10, 11]}}
{"token": ["We", "determined", "C1420554#ent", "<e1>", "concentration", "from", "motor", "cortex", "only", "4", "of", "our", "C1332754#ent", "<e2>", "cases", ",", "2", "demented", "and", "2", "non-demented", "."], "h": {"id": "C1420554", "name": "C1420554#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [12, 13]}}
{"token": ["C0004623#ent", "<e1>", "by", "Gram-negative", "bacteria", "as", "Vibrio", "sp.", "Aeromonas", "sp.", "and", "C0043407#ent", "<e2>", "been", "effectively", "controlled", "by", "vaccination", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0043407", "name": "C0043407#ent", "pos": [11, 12]}}
{"token": ["This", "effect", "was", "not", "altered", "by", "co-treatment", "with", "L-NAME", ",", "C0298346#ent", "<e1>", "or", "ICI182780", ",", "but", "was", "potentiated", "by", "LY294002", "and", "C1704669#ent", "<e2>", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704669", "name": "C1704669#ent", "pos": [21, 22]}}
{"token": ["The", "activity", "of", "PEP-carboxykinase", "but", "not", "of", "C1418288#ent", "<e1>", "reduced", ",", "indicating", "a", "decreased", "formation", "of", "C0034348#ent", "<e2>"], "h": {"id": "C1418288", "name": "C1418288#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034348", "name": "C0034348#ent", "pos": [16, 17]}}
{"token": ["To", "compare", "the", "acceptability", "and", "effects", "on", "temperature", "of", "advice", "to", "unwrap", "children", "and", "give", "C0000970#ent", "<e1>", "or", "warm", "sponging", "treatments", "in", "the", "management", "of", "C0015967#ent", "<e2>", "home", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [15, 16]}, "relation": "may_prevent", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [25, 26]}}
{"token": ["The", "CIBIS-III", "study", "showed", "that", "C0018801#ent", "<e1>", "be", "safely", "initiated", "with", "C0053799#ent", "<e2>", "followed", "by", "the", "addition", "of", "enalapril", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0053799", "name": "C0053799#ent", "pos": [11, 12]}}
{"token": ["Beneficial", "effects", "on", "the", "prognosis", "of", "the", "patients", "with", "mild", "to", "moderate", "C0018801#ent", "<e1>", "been", "shown", "with", "metoprolol", ",", "C0053799#ent", "<e2>", ",", "and", "carvedilol", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0053799", "name": "C0053799#ent", "pos": [19, 20]}}
{"token": ["Hypothyroidism", "frequently", "causes", "cardiovascular", "manifestations", "can", "complicate", "treatment", "of", "both", "the", "C3665349#ent", "<e1>", "and", "of", "any", "underlying", "C0018799#ent", "<e2>"], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [17, 18]}}
{"token": ["Twenty-three", "patients", "had", "Down's", "Syndrome", "four", "had", "schizophrenia", "disorders", "42", "had", "seizure", "disorders", "11", "had", "C3665349#ent", "<e1>", ",", "seven", "had", "C0018799#ent", "<e2>", "and", "14", "had", "central", "nervous", "system", "neuromuscular", "disorders"], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [20, 21]}}
{"token": ["In-111", "chloride", "imaging", "used", "in", "the", "evaluation", "of", "a", "patient", "with", "C1961835#ent", "<e1>", "splenectomy", "for", "C0030312#ent", "<e2>", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [15, 16]}}
{"token": ["Aldosterone", "secretion", "is", "more", "sensitive", "to", "C1704793#ent", "<e1>", "in", "cases", "of", "C1384514#ent", "<e2>", "in", "normal", "subjects"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1384514", "name": "C1384514#ent", "pos": [11, 12]}}
{"token": ["We", "studied", "diurnal", "variation", "the", "responses", "of", "plasma", "corticoids", "dexamethasone", "and", "C1704793#ent", "<e1>", "before", "and", "after", "adrenal", "surgery", "11", "patients", "with", "C1384514#ent", "<e2>"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1384514", "name": "C1384514#ent", "pos": [21, 22]}}
{"token": ["To", "assess", "patient", "satisfaction", "and", "preference", "for", "C0771993#ent", "<e1>", "previous", "\"", "nontriptan", "\"", "therapy", "for", "C0149931#ent", "<e2>", "."], "h": {"id": "C0771993", "name": "C0771993#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [15, 16]}}
{"token": ["Forced", "expression", "of", "C0796355#ent", "<e1>", "together", "with", "C2984123#ent", "<e2>", "or", "RBTN2", ",", "but", "not", "C0796355#ent", "<e1>", "alone", ",", "strongly", "induced", "artificial", "reporter", "genes", "a", "TAL1/RBTN-negative", "T-ALL", "cell", "line", ",", "HPB-ALL", "."], "h": {"id": "C0796355", "name": "C0796355#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2984123", "name": "C2984123#ent", "pos": [7, 8]}}
{"token": ["Extensive", "studies", "in", "lupus-prone", "mice", "strongly", "suggest", "that", "mAbs", "to", "C1332714#ent", "<e1>", "may", "be", "effective", "in", "C0024141#ent", "<e2>", "."], "h": {"id": "C1332714", "name": "C1332714#ent", "pos": [10, 11]}, "relation": "gene_associated_with_disease", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [16, 17]}}
{"token": ["We", "present", "an", "interesting", "case", "of", "a", "patient", "with", "long-standing", "severe", "hypertension", "and", "resultant", "C0022661#ent", "<e1>", "postrenal", "transplant", "developed", "a", "prolonged", "C0751188#ent", "<e2>", "mild", "severity"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751188", "name": "C0751188#ent", "pos": [21, 22]}}
{"token": ["S-", "and", "R-sulpiride", ",", "10", "mumol/l", ",", "C0013015#ent", "<e1>", "mumol/l", ",", "SCH", "23390", "1", "mumol/l", "and", "C0242546#ent", "<e2>", "mumol/l", "did", "not", "change", ",", "or", "even", "depressed", "the", "first", "e.j.ps", "."], "h": {"id": "C0013015", "name": "C0013015#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242546", "name": "C0242546#ent", "pos": [16, 17]}}
{"token": ["C1566790#ent", "<e1>", ",", "Smad3", ",", "and", "Smad4", "proteins", "signaling", "molecules", "which", "TGF-beta", "modulates", "C0812327#ent", "<e2>"], "h": {"id": "C1566790", "name": "C1566790#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [13, 14]}}
{"token": ["Although", "the", "assay", "detected", "C1145610#ent", "<e1>", "with", "steatorrhea", ",", "it", "did", "not", "consistently", "separate", "the", "C3540820#ent", "<e2>", "patients", "from", "normals", "."], "h": {"id": "C1145610", "name": "C1145610#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540820", "name": "C3540820#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "this", "assay", "in", "subjects", "including", "patients", "with", "C1145610#ent", "<e1>", "with", "steatorrhea", ",", "patients", "with", "C3540820#ent", "<e2>", "with", "no", "steatorrhea", "healthy", "controls", "and", "diseased", "controls", "with", "nonpancreatic", "malabsorption"], "h": {"id": "C1145610", "name": "C1145610#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540820", "name": "C3540820#ent", "pos": [22, 23]}}
{"token": ["The", "C3541394#ent", "<e1>", "were", "selected", "from", "the", "large", "Arabidopsis", "UGT", "C1517488#ent", "<e2>", "their", "previously", "identified", "putative", "endogenous", "substrates", "comprised", "both", "carboxylic", "acid", "and", "phenolic", "and", "aliphatic", "hydroxyl", "moieties", "as", "biochemical", "targets"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "c-Myc", "plays", "a", "fundamental", "role", "in", "the", "regulation", "of", "the", "expression", "of", "C1706006#ent", "<e1>", ",", "but", "not", "Fas", "and", "C0879590#ent", "<e2>", "."], "h": {"id": "C1706006", "name": "C1706006#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "the", "combination", "of", "clinical", "and", "basic", "research", "has", "better", "defined", "the", "involvement", "of", "C1839729#ent", "<e1>", "in", "a", "growing", "number", "of", "nervous", "pathologies", "than", "C1285162#ent", "<e2>"], "h": {"id": "C1839729", "name": "C1839729#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [25, 26]}}
{"token": ["The", "effect", "of", "chronic", "administration", "2(2-dimethylaminoethylthio)-3-phenylquinoline", "(", "C0123112#ent", "<e1>", ")", "and", "2(2-dimethylamino-2-methylpropylthio)-3-phenylquinoline", "(", "ICI-170,809", ")", ",", "two", "selective", "C2936522#ent", "<e2>", "on", "sleep", "was", "studied", "in", "rats", "."], "h": {"id": "C0123112", "name": "C0123112#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2936522", "name": "C2936522#ent", "pos": [18, 19]}}
{"token": ["In", "yeast", "two-hybrid", "assays", "C1709804#ent", "<e1>", "interacts", "with", "C1704871#ent", "<e2>", ",", "suggesting", "that", "C1709804#ent", "<e1>", "may", "function", "downstream", "from", "the", "MPS1", "pathway", "."], "h": {"id": "C1709804", "name": "C1709804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704871", "name": "C1704871#ent", "pos": [8, 9]}}
{"token": ["Chronic", "exposure", "to", "low", "levels", "of", "environmentally", "derived", "arsenite", "are", "associated", "with", "C0162819#ent", "<e1>", "such", "as", "C0027719#ent", "<e2>", "."], "h": {"id": "C0162819", "name": "C0162819#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027719", "name": "C0027719#ent", "pos": [16, 17]}}
{"token": ["Thirty", "patients", "with", "active", "definite", "C0003873#ent", "<e1>", "RA", ")", ",", "participated", "in", "a", "double-blind", "crossover", "study", "C0015837#ent", "<e2>", "placebo", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0015837", "name": "C0015837#ent", "pos": [16, 17]}}
{"token": ["Twenty-four", "patients", "suffering", "from", "C0003873#ent", "<e1>", "requiring", "articular", "punctures", "treated", "with", "mg", "of", "C0015837#ent", "<e2>", "thrice", "daily", "for", "four", "days", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0015837", "name": "C0015837#ent", "pos": [13, 14]}}
{"token": ["Together", ",", "C4050515#ent", "<e1>", "increased", "the", "expression", "of", "C1539102#ent", "<e2>", "leading", "to", "increased", "superoxide", "production"], "h": {"id": "C4050515", "name": "C4050515#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539102", "name": "C1539102#ent", "pos": [8, 9]}}
{"token": ["In", "this", "sporadic", "case", "was", "no", "overt", "immune", "dysfunction", "C0004135#ent", "<e1>", "inconspicuous", "and", "the", "neurological", "presentation", "atypical", "with", "C0393593#ent", "<e2>", "predominating", "over", "cerebellar", "incoordination"], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [18, 19]}}
{"token": ["In", "the", "second", "patient", ",", "severe", "C0014863#ent", "<e1>", "therapy", "until", "C0017887#ent", "<e2>", "the", "functional", "obstruction"], "h": {"id": "C0014863", "name": "C0014863#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [10, 11]}}
{"token": ["These", "C0038317#ent", "<e1>", "levels", "were", "significantly", "low", "in", "patients", "with", "C0001403#ent", "<e2>"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [10, 11]}}
{"token": ["Although", "hepatic", "arterial", "blood", "flow", "C3540525#ent", "<e1>", ")", "decreased", "dose-dependently", "in", "response", "to", "the", "infusion", "of", "dopamine", ",", "no", "significant", "was", "observed", "in", "C3540525#ent", "<e1>", "in", "response", "to", "any", "dose", "of", "C0700450#ent", "<e1>", "."], "h": {"id": "C3540525", "name": "C3540525#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0700450", "name": "C0700450#ent", "pos": [31, 32]}}
{"token": ["The", "enzymatic", "mechanism", "C0058594#ent", "<e1>", "was", "investigated", "using", "Escherichia", "coli", "baculoviral", "C3889446#ent", "<e2>", "mouse", "primase", "subunits", ",", "p49", "and", "p58", "."], "h": {"id": "C0058594", "name": "C0058594#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [11, 12]}}
{"token": ["Ribonuclease", "(", "RNase", ")", "T1", "is", "a", "C0018364#ent", "<e1>", ",", "having", "two", "C0022173#ent", "<e2>", "in", "nature", ",", "Gln25-", "and", "Lys25-RNase", "T1", "."], "h": {"id": "C0018364", "name": "C0018364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [12, 13]}}
{"token": ["After", "fluid", "restriction", "plasma", "AVP", "was", "uniformly", "normal", "relative", "to", "plasma", "osmolality", "patients", "with", "C0162283#ent", "<e1>", "primary", "polydipsia", "was", "distinctly", "subnormal", "in", "all", "patients", "with", "C0011848#ent", "<e2>"], "h": {"id": "C0162283", "name": "C0162283#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [25, 26]}}
{"token": ["Ten", "of", "these", "patients", "had", "C0162283#ent", "<e1>", "one", "had", "results", "suggestive", "of", "C0011848#ent", "<e2>", "but", "none", "had", "evidence", "of", "primary", "polydipsia"], "h": {"id": "C0162283", "name": "C0162283#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "for", "optimum", "prediction", "of", "recovery", "of", "function", "after", "C0155626#ent", "<e1>", ",", "a", "combination", "of", "DE", "and", "MCE", "in", "C0700450#ent", "<e2>", "nonresponsive", "segments", "may", "be", "utilized", "."], "h": {"id": "C0155626", "name": "C0155626#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0700450", "name": "C0700450#ent", "pos": [20, 21]}}
{"token": ["Globally", ",", "the", "greatest", "burden", "on", "human", "health", "that", "is", "attributable", "to", "this", "C0043528#ent", "<e1>", "is", "caused", "by", "uncontrolled", "C0034494#ent", "<e2>", "in", "dogs", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0034494", "name": "C0034494#ent", "pos": [19, 20]}}
{"token": ["C3665704#ent", "<e1>", "experiments", "demonstrated", "C1415975#ent", "<e2>", "binding", "by", "14", "and", "seven", "DF", "body", "and", "DF", "feces", "Ags", ",", "respectively", ",", "when", "CIE", "gels", "were", "incubated", "with", "reference", "sera", "clinically", "mite-sensitive", "patients", "."], "h": {"id": "C3665704", "name": "C3665704#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [4, 5]}}
{"token": ["Researchers", "are", "currently", "investigating", "whether", "other", "C0243051#ent", "<e1>", "be", "partially", "involved", "and", "are", "investigating", "whether", "C0991617#ent", "<e2>", "that", "affect", "these", "other", "systems", "will", "prove", "complementary", "to", "currently", "used", "treatments", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [15, 16]}}
{"token": ["The", "activity", "of", "C0248685#ent", "<e1>", "the", "liver", "was", "not", "altered", "in", "C0235950#ent", "<e2>"], "h": {"id": "C0248685", "name": "C0248685#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235950", "name": "C0235950#ent", "pos": [11, 12]}}
{"token": ["Addition", "of", "C1516312#ent", "<e1>", "as", "Z-VAD-FMK", "inhibited", "apoptosis", "and", "C1413274#ent", "<e2>", "degradation", "."], "h": {"id": "C1516312", "name": "C1516312#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413274", "name": "C1413274#ent", "pos": [9, 10]}}
{"token": ["Collectively", ",", "these", "data", "indicate", "that", "the", "pathogenesis", "of", "C0022658#ent", "<e1>", "in", "the", "ZSF1", "model", "of", "C0011881#ent", "<e2>", "largely", "independent", "of", "differences", "in", "systemic", "BP", "its", "potential", "renal", "transmission"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [16, 17]}}
{"token": ["Checkpoint", "kinase", "2", "C1259236#ent", "<e1>", ")", "is", "a", "C0031727#ent", "<e2>", "in", "which", "the", "yeast", "counterpart", "regulates", "a", "cell", "cycle", "checkpoint", "causes", "cells", "to", "arrest", "proliferation", "DNA", "damage"], "h": {"id": "C1259236", "name": "C1259236#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}}
{"token": ["The", "role", "of", "C1334752#ent", "<e1>", ",", "microtubules", ",", "and", "C1979930#ent", "<e2>", "MAP", ")", "kinase", "in", "regulation", "of", "several", "important", "dynamic", "events", "of", "porcine", "oocyte", "maturation", "and", "fertilization", "is", "described", "."], "h": {"id": "C1334752", "name": "C1334752#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1979930", "name": "C1979930#ent", "pos": [9, 10]}}
{"token": ["The", "ratio", "was", "less", "than", "10", "in", "68", "%", "of", "C1414026#ent", "<e1>", "but", "in", "only", "27", "%", "of", "C0011854#ent", "<e2>", "patients", "(", "p", "less", "than", "0.01", ")", "."], "h": {"id": "C1414026", "name": "C1414026#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "C0602588#ent", "<e1>", "was", "tested", "for", "its", "inhibitory", "action", "on", "C3541394#ent", "<e2>", "."], "h": {"id": "C0602588", "name": "C0602588#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [12, 13]}}
{"token": ["Differentiation", "of", "C0027947#ent", "<e1>", "induced", "by", "C0014544#ent", "<e2>", "from", "C0027947#ent", "<e1>", "due", "to", "anticonvulsants", "enabled", "one", "to", "reveal", "that", "incidence", "of", "the", "latter", "amounts", "to", "6", "%", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [6, 7]}}
{"token": ["Based", "on", "RAPD", "analysis", "the", "average", "similarity", "coefficients", "between", "C1418981#ent", "<e1>", "and", "C1425488#ent", "<e2>", "were", "35", "%", "and", "34", "%", "between", "C1425488#ent", "<e2>", "and", "V.", "tricorpus", "."], "h": {"id": "C1418981", "name": "C1418981#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425488", "name": "C1425488#ent", "pos": [12, 13]}}
{"token": ["The", "main", "part", "of", "the", "deduced", "amino", "acid", "of", "the", "14.6", "kD", "C1418981#ent", "<e1>", "and", "the", "larger", "C1425488#ent", "<e2>", "consists", "of", "glycine-rich", "repetitive", "elements", "essentially", "as", "found", "for", "GRPs", "in", "other", "plants", "."], "h": {"id": "C1418981", "name": "C1418981#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1425488", "name": "C1425488#ent", "pos": [17, 18]}}
{"token": ["Activation", "ratio", "cAMP-dependent", "protein", "kinase", "cultured", "type", "II", "cells", "increased", "significantly", "in", "the", "presence", "of", "C0039542#ent", "<e1>", ",", "C0917964#ent", "<e2>", ",", "or", "C0039542#ent", "<e1>", "plus", "C0917964#ent", "<e2>", "."], "h": {"id": "C0039542", "name": "C0039542#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [18, 19]}}
{"token": ["C0597979#ent", "<e1>", "(", "MbetaLs", ")", "are", "bacterial", "Zn(II)-dependent", "C0020289#ent", "<e2>", "that", "confer", "broad-spectrum", "resistance", "to", "beta-lactam", "antibiotics"], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [8, 9]}}
{"token": ["The", "antibiotic", "susceptibilities", "and", "capabilities", "to", "induce", "C0597979#ent", "<e1>", "were", "studied", "in", "multiple", "Escherichia", "coli", "murein", "peptidoglycan", ")", "C0020289#ent", "<e2>", "mutants", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [18, 19]}}
{"token": ["Body", "and", "scalp", "lesions", "and", "C1422257#ent", "<e1>", "regressed", "considerably", "and", "significantly", "with", "C0022625#ent", "<e2>", "in", "all", "but", "five", "patients", ",", "three", "of", "whom", "subsequently", "responded", "to", "a", "higher", "dose", "."], "h": {"id": "C1422257", "name": "C1422257#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [12, 13]}}
{"token": ["Using", "polymerase", "chain", "reaction", "primers", "based", "on", "the", "CYP6D1v1", "allele", ",", "the", "sequences", "5", "'", "to", "the", "C0079941#ent", "<e1>", "were", "obtained", "from", "five", "C3536822#ent", "<e2>", "susceptible", "strains", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3536822", "name": "C3536822#ent", "pos": [23, 24]}}
{"token": ["Since", "the", "introduction", "of", "C0003207#ent", "<e1>", "endophthalmitis", "has", "rarely", "been", "observed", "as", "a", "complication", "of", "C0025303#ent", "<e2>"], "h": {"id": "C0003207", "name": "C0003207#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025303", "name": "C0025303#ent", "pos": [15, 16]}}
{"token": ["To", "date", ",", "2", "genetic", "forms", "been", "associated", "with", "mutations", "in", "PANK2", "and", "C1418624#ent", "<e1>", ",", "both", "of", "which", "encode", "C0086376#ent", "<e2>", "that", "are", "critical", "to", "membrane", "integrity"], "h": {"id": "C1418624", "name": "C1418624#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [20, 21]}}
{"token": ["Symptoms", "of", "C0017536#ent", "<e1>", "include", "upper", "abdominal", "pain", "distress", ",", "flatulence", ",", "C0849963#ent", "<e2>", ",", "and", "diarrhea", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0849963", "name": "C0849963#ent", "pos": [12, 13]}}
{"token": ["SOH", "was", "sensitive", "to", "the", "inhibition", "by", "a", "C3850060#ent", "<e1>", "sulfaphenazole", ",", "and", "C3850057#ent", "<e2>", "4-methylpyrazole", "and", "diethyldithiocarbamate", "."], "h": {"id": "C3850060", "name": "C3850060#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3850057", "name": "C3850057#ent", "pos": [13, 14]}}
{"token": ["At", "a", "calcium", "concentration", "0.9", "mmol/l", "the", "potency", "order", "for", "this", "effect", "was", ":", "C0035983#ent", "<e1>", "greater", "than", "nifedipine", "=", "C0042523#ent", "<e2>", "greater", "than", "diltiazem", "=", "bepridil", "=", "lidoflazine", "greater", "than", "TMB-8", "."], "h": {"id": "C0035983", "name": "C0035983#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [20, 21]}}
{"token": ["The", "authors", "report", "a", "case", "of", "symptomatic", "C0006105#ent", "<e1>", "a", "51-year-old", "man", "who", "presented", "with", "personality", "changes", "C0234533#ent", "<e2>"], "h": {"id": "C0006105", "name": "C0006105#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [17, 18]}}
{"token": ["An", "oligonucleotide", "probe", "for", "only", "the", "52", "C2917660#ent", "<e1>", "confirmed", "the", "overexpression", "of", "C1421257#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421257", "name": "C1421257#ent", "pos": [13, 14]}}
{"token": ["The", "minimum", "C0003308#ent", "<e1>", "concentrations", "(", "mg/L", ")", "of", "C0936148#ent", "<e2>", "for", "A.", "fumigatus", "n", "=", "58", ")", "and", "non-A.", "fumigatus", "aspergilli", "n", "=", "40", ")", "were", "4", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0936148", "name": "C0936148#ent", "pos": [9, 10]}}
{"token": ["Hydrolyzed", "enantiomerically", "pure", "C0022638#ent", "<e1>", "were", "cyclized", "to", "C0220821#ent", "<e2>", "."], "h": {"id": "C0022638", "name": "C0022638#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0220821", "name": "C0220821#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "deletions", "of", "the", "C1855681#ent", "<e1>", "usually", "responsible", "for", "isolated", "juvenile", "nephronophthisis", "are", "occasionally", "encountered", "among", "C0431399#ent", "<e2>", "syndrome-related", "disorder", "patients", "."], "h": {"id": "C1855681", "name": "C1855681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0431399", "name": "C0431399#ent", "pos": [18, 19]}}
{"token": ["These", "results", "suggest", "that", "MCTs", "in", "proliferative", "C0011884#ent", "<e1>", "shortened", "soon", "after", "C0032027#ent", "<e2>", "."], "h": {"id": "C0011884", "name": "C0011884#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032027", "name": "C0032027#ent", "pos": [12, 13]}}
{"token": ["Acute", "ocular", "complications", "of", "C0014742#ent", "<e1>", "as", "infection", "causing", "C0009763#ent", "<e2>", ",", "suppurative", "keratitis", "endophthalmitis", "are", "well", "recognized", "and", "usually", "easily", "managed", "."], "h": {"id": "C0014742", "name": "C0014742#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [9, 10]}}
{"token": ["Addition", "of", "C2825838#ent", "<e1>", "these", "effects", "of", "HGF", "on", "C0166027#ent", "<e2>", "and", "collagen", "synthesis", "."], "h": {"id": "C2825838", "name": "C2825838#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [9, 10]}}
{"token": ["Carbon", "catabolite", "repression", "in", "Bacillus", "subtilis", "mediated", "by", "phosphorylation", "of", "the", "phosphoenolpyruvate", ":", "carbohydrate", "phosphotransferase", "system", "C1337105#ent", "<e1>", "at", "a", "serine", "residue", "catalyzed", "by", "C0671841#ent", "<e2>"], "h": {"id": "C1337105", "name": "C1337105#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0671841", "name": "C0671841#ent", "pos": [24, 25]}}
{"token": ["The", "analgesic", "effect", "C0060313#ent", "<e1>", "was", "investigated", "in", "comparison", "with", "those", "of", "C0003211#ent", "<e2>", "NSAIDs", ")", "."], "h": {"id": "C0060313", "name": "C0060313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}}
{"token": ["Western-blot", "analysis", "monoclonal", "antibodies", "TnI", "and", "C2240312#ent", "<e1>", "showed", "that", "mu-calpain", "was", "at", "least", "ten", "times", "more", "active", "than", "C1120859#ent", "<e2>", "in", "degrading", "TnI", "and", "C2240312#ent", "<e1>", "both", "in", "vitro", "in", "situ"], "h": {"id": "C1120859", "name": "C1120859#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2240312", "name": "C2240312#ent", "pos": [6, 7]}}
{"token": ["C1417827#ent", "<e1>", "and", "CAR3", "are", "not", "required", "for", "transcription", "of", "the", "PDI", "gene", "but", "deleting", "C1417827#ent", "<e1>", "leads", "to", "C0001622#ent", "<e1>", "of", "the", "PDI", "transcript", "."], "h": {"id": "C1417827", "name": "C1417827#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [19, 20]}}
{"token": ["The", "activity", "of", "lysophosphatidylcholine", "acyltransferase", "C1425131#ent", "<e1>", "glycerol-3-phosphate", "acyltransferase(s)", "as", "well", "as", "the", "activity", "of", "C1416867#ent", "<e2>", "decreased", "in", "the", "microsomes", "of", "cerebral", "hemispheres", "animals", "intermittently", "exposed", "to", "hypoxic", "treatment", "for", "eighty", "hours", "."], "h": {"id": "C1425131", "name": "C1425131#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [15, 16]}}
{"token": ["The", "structure", "of", "C0074088#ent", "<e1>", "is", "very", "similar", "to", "those", "of", "homologous", "C0038601#ent", "<e2>"], "h": {"id": "C0074088", "name": "C0074088#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038601", "name": "C0038601#ent", "pos": [12, 13]}}
{"token": ["Ten", "out", "of", "22", "patients", "responded", "to", "C0054085#ent", "<e1>", "and", "5", "out", "of", "17", "patients", "to", "C0040778#ent", "<e2>", "."], "h": {"id": "C0054085", "name": "C0054085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040778", "name": "C0040778#ent", "pos": [16, 17]}}
{"token": ["The", "region", "encompassing", "C3539947#ent", "<e1>", "-", "1092", "of", "the", "human", "C0388246#ent", "<e2>", ",", "together", "with", "the", "NLS", "containing", "C3539947#ent", "<e1>", "-", "1432", ",", "provides", "the", "targeting", "to", "the", "nucleoli", "."], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [3, 4]}}
{"token": ["Whereas", "C0040034#ent", "<e1>", "has", "been", "reported", "previously", "in", "patients", "with", "C0343900#ent", "<e2>", "it", "appears", "that", "C0040034#ent", "<e1>", "in", "a", "patient", "with", "nondisseminated", "histoplasmosis", "has", "not", "been", "described", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0343900", "name": "C0343900#ent", "pos": [10, 11]}}
{"token": ["These", "findings", "expand", "the", "known", "signaling", "functions", "C1704657#ent", "<e1>", "and", "provide", "insight", "into", "signal", "transduction", "associated", "with", "C0720831#ent", "<e2>", "phagocytosis", "in", "response", "to", "E.", "coli"], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0720831", "name": "C0720831#ent", "pos": [17, 18]}}
{"token": ["When", "extracted", "from", "several", "C2930156#ent", "<e1>", "they", "exhibit", "C0003280#ent", "<e2>", "properties", "."], "h": {"id": "C2930156", "name": "C2930156#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [8, 9]}}
{"token": ["This", "decrease", "in", "urinary", "excretion", "C3273436#ent", "<e1>", "in", "patients", "with", "recent-onset", "diabetes", "mellitus", "a", "possible", "role", "of", "C3273436#ent", "<e1>", "in", "the", "pathogenesis", "of", "early", "C0011881#ent", "<e1>"], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [24, 25]}}
{"token": ["C0150055#ent", "<e1>", "delineated", "into", "C1417685#ent", "<e2>", "and", "musculoskeletal", "components", "noting", "changes", "in", "nature", ",", "quality", ",", "and", "severity", "of", "pain", "(", "visual", "analogue", "scale", "and", "use", "of", "analgesic", "medications"], "h": {"id": "C0150055", "name": "C0150055#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417685", "name": "C1417685#ent", "pos": [4, 5]}}
{"token": ["C1335554#ent", "<e1>", "PTP-SL", "retains", "mitogen-activated", "protein", "MAP", ")", "C0010536#ent", "<e2>", "in", "the", "cytoplasm", "in", "an", "inactive", "form", "by", "association", "through", "a", "kinase", "interaction", "motif", "KIM", ")", "and", "tyrosine", "dephosphorylation"], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [8, 9]}}
{"token": ["The", "genes", "were", ":", "SHP1", ",", "a", "C1335554#ent", "<e1>", "SYK", ",", "a", "C0010536#ent", "<e2>", "and", "SOCS1", ",", "a", "suppressor", "of", "cytokine", "signaling"], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [12, 13]}}
{"token": ["In", "an", "intensive", "prospective", "drug", "monitoring", "of", "1,920", "patients", ",", "172", "(", "8.9", "%", ")", "had", "C0023890#ent", "<e1>", "of", "the", "liver", "and", "received", "C0016860#ent", "<e2>", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [23, 24]}}
{"token": ["Patients", "with", "C0023890#ent", "<e1>", "and", "with", "or", "without", "ascites", "responded", "to", "C0016860#ent", "<e2>", "probably", "associated", "with", "elution", "of", "vasoconstrictive", "substances", "the", "same", "way", "as", "the", "control", "group"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [11, 12]}}
{"token": ["C0022625#ent", "<e1>", "%", "has", "been", "developed", "for", "the", "once-daily", "treatment", "of", "C0036508#ent", "<e2>"], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0036508", "name": "C0036508#ent", "pos": [11, 12]}}
{"token": ["Topical", "C0022625#ent", "<e1>", "(", "KC", ")", "is", "considered", "a", "standard", "treatment", "C0036508#ent", "<e2>"], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0036508", "name": "C0036508#ent", "pos": [11, 12]}}
{"token": ["A", "randomized", "double-blind", "placebo-controlled", "cross-over", "study", "was", "made", "of", "C0022625#ent", "<e1>", "200", "mg", "daily", "in", "nineteen", "patients", "with", "C0036508#ent", "<e2>"], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0036508", "name": "C0036508#ent", "pos": [18, 19]}}
{"token": ["end-1", ",", "a", "C0079429#ent", "<e1>", "from", "the", "C1422341#ent", "<e2>", ",", "restores", "endoderm", "production", "in", "EDR", "deficiency", "homozygotes", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422341", "name": "C1422341#ent", "pos": [7, 8]}}
{"token": ["C0031669#ent", "<e1>", "phosphorylation", "of", "C1423827#ent", "<e2>", "in", "32P-labelled", "platelets", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423827", "name": "C1423827#ent", "pos": [4, 5]}}
{"token": ["Increased", "levels", "of", "transcript", "may", "be", "causally", "related", "to", "the", "POF", "or", "C0559483#ent", "<e1>", "phenotypes", "or", "may", "be", "a", "surrogate", "of", "some", "other", "C0002085#ent", "<e2>", "property", "."], "h": {"id": "C0559483", "name": "C0559483#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [23, 24]}}
{"token": ["ATP", "also", "induced", "a", "slight", "increase", "in", "C1705265#ent", "<e1>", "mRNA", "but", "was", "ineffective", "in", "inducing", "C0079068#ent", "<e2>", "expression", "in", "these", "cells", "."], "h": {"id": "C1705265", "name": "C1705265#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [15, 16]}}
{"token": ["The", "role", "of", "basicity", "of", "the", "amine", "group", "amphotericin", "B", "the", "molecular", "mechanism", "C0003308#ent", "<e1>", "this", "antibiotic", "has", "been", "investigated", "by", "C1335808#ent", "<e2>", "and", "MNDO", "quantum", "chemistry", "methods"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335808", "name": "C1335808#ent", "pos": [21, 22]}}
{"token": ["Using", "C0054549#ent", "<e1>", "we", "determined", "that", "Jurkat", "adhesion", "to", "C1706331#ent", "<e2>", "was", "regulated", "via", "protein", "phosphatase", "1", "independent", "of", "the", "levels", "of", "integrins", "or", "integrin", "activation", "epitopes", "."], "h": {"id": "C0054549", "name": "C0054549#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [9, 10]}}
{"token": ["The", "properties", "of", "C0018437#ent", "<e1>", "from", "rat", "C0023899#ent", "<e2>", "lysosomes", "were", "analyzed", "by", "reconstituting", "proton", "pump", "activity", "from", "solubilized", "enzyme", "and", "Escherichia", "coli", "phospholipids", "in", "proteoliposomes", "devoid", "of", "anion-channels", "."], "h": {"id": "C0018437", "name": "C0018437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}}
{"token": ["The", "C0018437#ent", "<e1>", "ATPase", "from", "rat", "C0023899#ent", "<e2>", "mitochondria", "can", "be", "disaggregated", "selectively", "to", "yield", "two", "distinct", ",", "stable", "complexes", "of", "the", "rutamycin-insensitive", "ATPase", "."], "h": {"id": "C0018437", "name": "C0018437#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}}
{"token": ["Costs", "for", "preventing", "one", "stroke", "by", "means", "of", "C0001645#ent", "<e1>", "amount", "to", "C2347281#ent", "<e2>", "3500", "and", "by", "ACE-inhibitor", "agents", "C2347281#ent", "<e2>", "11,500", ",", "respectively", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2347281", "name": "C2347281#ent", "pos": [12, 13]}}
{"token": ["In", "a", "coupled", "system", "with", "the", "C0027021#ent", "<e1>", ",", "H2O2", ",", "SCN-", ",", "GSH", ",", "NADPH", "and", "C1415326#ent", "<e2>", "peroxidase-catalysed", "SCN-", "oxidation", "by", "H2O2", "could", "be", "coupled", "to", "NADPH", "consumption", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415326", "name": "C1415326#ent", "pos": [17, 18]}}
{"token": ["The", "homozygous", "beta-thalassemias", "are", "a", "group", "of", "C1516876#ent", "<e1>", "inherited", "hemoglobin", "(", "Hb", ")", "disorders", "characterized", "by", "C0002876#ent", "<e2>"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002876", "name": "C0002876#ent", "pos": [17, 18]}}
{"token": ["We", "investigated", "the", "effects", "of", "C0002260#ent", "<e1>", ",", "an", "inhibitor", "of", "ornithine", "decarboxylase", "C0029282#ent", "<e2>", ")", "and", "selenium", "supplementation", "on", "tumor", "formation", "induced", "by", "the", "carcinogen", "1,2-dimethylhydrazine", "DMH", ")", "in", "Sprague-Dawley", "rats"], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [13, 14]}}
{"token": ["Treatment", "with", "C0002260#ent", "<e1>", ",", "a", "selective", "inactivator", "of", "C0029282#ent", "<e2>", "the", "accumulation", "of", "active", "enzyme", ",", "but", "did", "not", "prevent", "morphological", "healing", "."], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [9, 10]}}
{"token": ["Both", "the", "crude", "and", "the", "purified", "enzyme", "preparations", "are", "inactivated", "irreversibly", "by", "C0002260#ent", "<e1>", ",", "a", "suicide", "inhibitor", "of", "mammalian", "C0029282#ent", "<e2>"], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [12, 13]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [20, 21]}}
{"token": ["C0002260#ent", "<e1>", "is", "a", "specific", "inhibitor", "of", "C0029282#ent", "<e2>", "Ifenprodil", "is", "an", "inhibitor", "of", "the", "polyamine", "binding", "site", "the", "n-methyl-d-aspartate", "receptor", "and", "MK-801", "is", "an", "antagonist", "to", "n-methyl-d-aspartate", "binding", "the", "n-methyl-d-aspartate", "receptor"], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [7, 8]}}
{"token": ["A", "useful", "system", "to", "evaluate", "the", "angiogenic", "activity", "the", "inflammatory", "potency", "various", "C0035064#ent", "<e1>", "is", "the", "chorioallantoic", "membrane", "C1861821#ent", "<e2>", ")", "of", "the", "chick", "embryo"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1861821", "name": "C1861821#ent", "pos": [18, 19]}}
{"token": ["C0033860#ent", "<e1>", "is", "a", "C3875321#ent", "<e2>", "pathogenesis", "and", "genetic", "background", "unclear", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3875321", "name": "C3875321#ent", "pos": [4, 5]}}
{"token": ["These", "findings", "establish", "Cyclin", "D2", "C0246957#ent", "<e1>", "as", "direct", "transcriptional", "targets", "of", "C1414995#ent", "<e2>", "and", "support", "a", "model", "in", "which", "C1414995#ent", "<e2>", "controls", "cardiomyocyte", "proliferation", "by", "coordinately", "regulating", "numerous", "cell", "cycle", "genes"], "h": {"id": "C0246957", "name": "C0246957#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414995", "name": "C1414995#ent", "pos": [12, 13]}}
{"token": ["The", "C3537103#ent", "<e1>", "NNRTI", ")", "UC781", "is", "under", "development", "as", "a", "C1136255#ent", "<e2>", "to", "prevent", "sexual", "transmission", "the", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "."], "h": {"id": "C3537103", "name": "C3537103#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1136255", "name": "C1136255#ent", "pos": [11, 12]}}
{"token": ["Mood", "disorder", "one", "characteristic", "symptom", "in", "several", "families", "of", "C0162674#ent", "<e1>", "caused", "by", "mutations", "of", "three", "genes", ",", "ANT1", ",", "C1418458#ent", "<e2>", ",", "and", "POLG", "."], "h": {"id": "C0162674", "name": "C0162674#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418458", "name": "C1418458#ent", "pos": [20, 21]}}
{"token": ["A", "short", "cut", "review", "was", "carried", "out", "to", "establish", "whether", "C0010547#ent", "<e1>", "adversely", "affected", "haemodynamic", "parameters", "in", "patients", "with", "C0018799#ent", "<e2>"], "h": {"id": "C0010547", "name": "C0010547#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", ",", "the", "acute", "effects", "C0077857#ent", "<e1>", "and", "diltiazem", "in", "patients", "with", "mild", "PH", "secondary", "to", "C0041912#ent", "<e2>", "were", "investigated", "."], "h": {"id": "C0077857", "name": "C0077857#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [18, 19]}}
{"token": ["This", "study", "depicts", "the", "clinical", "characteristics", "and", "short-term", "outcomes", "of", "patients", "with", "C1419818#ent", "<e1>", "treated", "at", "Taipei", "Veterans", "General", "Hospital", "potential", "predictive", "factors", "C0035220#ent", "<e2>", "ARDS", ")", "are", "also", "analyzed", "."], "h": {"id": "C1419818", "name": "C1419818#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [23, 24]}}
{"token": ["Risk", "factors", "ischaemic", "heart", "disease", "C0020480#ent", "<e1>", ",", "being", "an", "ex-smoker", "40", "years", "ago", ",", "no", "history", "C0011847#ent", "<e2>", "or", "hypertension", "."], "h": {"id": "C0020480", "name": "C0020480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [17, 18]}}
{"token": ["A", "stock", "solution", "of", "sodium", "salts", "glycochenodeoxycholic", "acid", "GCDC", ")", ",", "taurodeoxycholic", "acid", "TDC", ")", ",", "and", "glycocholic", "acid", "C1367452#ent", "<e1>", ")", ",", "was", "added", "to", "each", "prepared", "sample", "of", "C0541154#ent", "<e2>", "HCl", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0541154", "name": "C0541154#ent", "pos": [30, 31]}}
{"token": ["These", "observations", "suggest", "that", "Cdc42", "is", "the", "primary", "C0018296#ent", "<e1>", "functioning", "during", "mitosis", "but", "that", "the", "other", "four", "C0968598#ent", "<e2>", "also", "assume", "the", "mitotic", "role", "in", "its", "absence", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0968598", "name": "C0968598#ent", "pos": [18, 19]}}
{"token": ["The", "celiac", "sprue", "a", "C0341268#ent", "<e1>", "becoming", "apparent", "by", "a", "C0024523#ent", "<e2>", "is", "caused", "by", "gluten", "respectively", "gliadin", "intolerance", "which", "leads", "to", "intestinal", "mucosal", "damage", "resulting", "in", "complete", "villous", "atrophy"], "h": {"id": "C0341268", "name": "C0341268#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [10, 11]}}
{"token": ["We", "show", "that", "the", "basic", "C1420632#ent", "<e1>", "dHAND", "is", "expressed", "posteriorly", "in", "the", "developing", "C0030196#ent", "<e2>", "prior", "to", "Shh", "and", "subsequently", "occupies", "a", "broad", "domain", "that", "encompasses", "the", "Shh", "expression", "domain", "."], "h": {"id": "C1420632", "name": "C1420632#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "the", "efficacy", "of", "C0016157#ent", "<e1>", "Portuguese", "patients", "with", "C0020557#ent", "<e2>", "and", "mixed", "hyperlipidaemia", "and", "the", "influence", "of", "fish", "consumption", "on", "the", "triglyceride", "lowering", "capacity", "of", "C0016157#ent", "<e1>"], "h": {"id": "C0016157", "name": "C0016157#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [10, 11]}}
{"token": ["C0016157#ent", "<e1>", "in", "omega-3", "fatty", "acids", "remarkably", "C0020557#ent", "<e2>", "in", "both", "normal", "and", "hypertriglyceridemic", "subjects", "."], "h": {"id": "C0016157", "name": "C0016157#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020557", "name": "C0020557#ent", "pos": [7, 8]}}
{"token": ["This", "C0031686#ent", "<e1>", "was", "also", "present", "in", "purified", "C0042214#ent", "<e2>", "with", "radioactive", "phosphate"], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042214", "name": "C0042214#ent", "pos": [8, 9]}}
{"token": ["We", "report", "six", "HIV", "patients", "who", "developed", "C0239377#ent", "<e1>", "periungual", "inflammation", "several", "nails", "during", "treatment", "with", "the", "C0003451#ent", "<e2>", "indinavir", "and", "lamivudine", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [17, 18]}}
{"token": ["We", "demonstrate", "that", "the", "activation", "of", "a", "C1413179#ent", "<e1>", "cyclin", "D2", "is", "an", "early", "event", "infection", "with", "C0149678#ent", "<e2>", "and", "that", "cyclin", "D2", "activation", "is", "dependent", "on", "the", "expression", "of", "viral", "genes"], "h": {"id": "C1413179", "name": "C1413179#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [17, 18]}}
{"token": ["To", "investigate", "the", "relationship", "between", "C0960580#ent", "<e1>", "genotypes", "and", "the", "hydroxylation", "index", "HI", ")", "of", "C0028978#ent", "<e2>", "in", "the", "South", "Indian", "population", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [15, 16]}}
{"token": ["Previous", "work", "has", "shown", "that", "the", "C0079429#ent", "<e1>", "for", "the", "alpha", "subunit", "androgen-binding", "protein", "C0004031#ent", "<e2>", ",", "may", "be", "involved", "in", "premating", "isolation", "different", "subspecies", "of", "the", "house", "mouse", "Mus", "musculus"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004031", "name": "C0004031#ent", "pos": [14, 15]}}
{"token": ["We", "report", "here", "that", "PIASx", ",", "a", "member", "of", "the", "C1418370#ent", "<e1>", "activated", "STAT", "(", "C1413968#ent", "<e2>", ")", "family", ",", "is", "a", "negative", "regulator", "of", "Stat4", "."], "h": {"id": "C1418370", "name": "C1418370#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413968", "name": "C1413968#ent", "pos": [15, 16]}}
{"token": ["Members", "of", "the", "C1418370#ent", "<e1>", "activated", "signal", "transducer", "and", "activator", "of", "transcription", "STAT", ")", "family", "(", "C1413968#ent", "<e2>", "family", ")", "of", "proteins", "act", "as", "negative", "regulators", "of", "STATs", "in", "cytokine", "signaling"], "h": {"id": "C1418370", "name": "C1418370#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413968", "name": "C1413968#ent", "pos": [16, 17]}}
{"token": ["Coexpression", "of", "C1427425#ent", "<e1>", "with", "constitutively", "active", "MEK1", "or", "C1442512#ent", "<e2>", "fails", "to", "increase", "C1427425#ent", "<e1>", "phosphorylation", "or", "activity", ",", "suggesting", "that", "MEKs", "are", "not", "involved", "."], "h": {"id": "C1442512", "name": "C1442512#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1427425", "name": "C1427425#ent", "pos": [2, 3]}}
{"token": ["The", "effects", "on", "memory", "and", "psychomotor", "performance", "and", "the", "subjective", "effects", "three", "C0005064#ent", "<e1>", "lorazepam", "2", ",", "diazepam", "10", "mg", "and", "C0055891#ent", "<e2>", "20", "mg", "p.o", ".", ")"], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [12, 13]}, "relation": "structural_class_of", "t": {"id": "C0055891", "name": "C0055891#ent", "pos": [21, 22]}}
{"token": ["The", "technique", "detects", "all", "of", "the", "commonly", "encountered", "C0005064#ent", "<e1>", "and", "others", "except", "C0055891#ent", "<e2>", ",", "which", "contains", "no", "azomethine", "group", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [8, 9]}, "relation": "structural_class_of", "t": {"id": "C0055891", "name": "C0055891#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "indicate", "that", "CpG", "DNA", "the", "p38", "and", "c-Jun", "NH2-terminal", "kinase", "MAPK", "leads", "to", "the", "activation", "of", "C0812312#ent", "<e1>", "via", "a", "pathway", "which", "is", "sensitive", "to", "C0008269#ent", "<e2>", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [27, 28]}}
{"token": ["Exercise", "has", "long", "been", "accepted", "as", "an", "C1510809#ent", "<e1>", "the", "management", "of", "C0011847#ent", "<e2>", "in", "nonpregnant", "subjects", "."], "h": {"id": "C1510809", "name": "C1510809#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [12, 13]}}
{"token": ["This", "suggests", "that", "C0017874#ent", "<e1>", "transfers", "heptadecanoic", "octadecanoic", ",", "and", "nonadecanoic", "acids", "whereas", "C0243546#ent", "<e2>", "transfers", "pentadecanoic", "and", "hexadecanoic", "acids"], "h": {"id": "C0017874", "name": "C0017874#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243546", "name": "C0243546#ent", "pos": [13, 14]}}
{"token": ["In", "the", "past", "decade", ",", "the", "genetic", "causes", "underlying", "familial", "forms", "many", "neurodegenerative", "disorders", "such", "as", "Huntington's", "disease", "Parkinson's", "disease", "Alzheimer's", "disease", "C0002736#ent", "<e1>", "Friedreich", "ataxia", "hereditary", "spastic", "paraplegia", "dominant", "optic", "atrophy", "Charcot-Marie-Tooth", "type", "2A", "neuropathy", "ataxia", "retinitis", "pigmentosa", "and", "C0029125#ent", "<e2>", "been", "elucidated", "."], "h": {"id": "C0002736", "name": "C0002736#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0029125", "name": "C0029125#ent", "pos": [40, 41]}}
{"token": ["Two", "agonists", ",", "GABA", "and", "muscimol", ",", "two", "C0005064#ent", "<e1>", ",", "flunitrazepam", "and", "C0002333#ent", "<e2>", ",", "together", "with", "the", "general", "anaesthetic", "halothane", "have", "been", "docked", "to", "this", "model", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [8, 9]}, "relation": "chemical_structure_of", "t": {"id": "C0002333", "name": "C0002333#ent", "pos": [13, 14]}}
{"token": ["All", "paper", "properties", "showing", "a", "correlation", "with", "C0014442#ent", "<e1>", "kinetic", "parameters", "were", "related", "to", "C0225326#ent", "<e2>", "interactions", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [14, 15]}}
{"token": ["C0014442#ent", "<e1>", "(", "uricase", "or", "invertase", ")", "was", "entrap-immobilized", "in", "C0225326#ent", "<e2>", "cellulose", "acetate-TiO2", "by", "using", "a", "gel", "formation", "cellulose", "acetate", "titanium", "iso-propoxide", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [10, 11]}}
{"token": ["Rapid", "eye", "movement", "sleep", "behavior", "disorder", "RBD", ")", "occurs", "in", "approximately", "one", "third", "of", "patients", "with", "Parkinson's", "disease", "C3160718#ent", "<e1>", ")", "and", "is", "associated", "with", "loss", "of", "C0393593#ent", "<e2>", "REM", "sleep", "and", "aggressive", "dream", "content"], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [18, 19]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [27, 28]}}
{"token": ["Clinical", "differential", "diagnoses", "the", "C0235031#ent", "<e1>", "potential", "therapeutic", "approaches", "these", "C0029896#ent", "<e2>", ",", "which", "may", "vary", "depending", "on", "the", "underlying", "pathology", ",", "are", "given", "."], "h": {"id": "C0235031", "name": "C0235031#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [10, 11]}}
{"token": ["This", "enhanced", "incorporation", "was", "abolished", "by", "C0040979#ent", "<e1>", ",", "but", "not", "by", "C0243460#ent", "<e2>"], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0243460", "name": "C0243460#ent", "pos": [12, 13]}}
{"token": ["A", "21-year-old", "young", "man", "with", "Down's", "syndrome", "with", "C0086132#ent", "<e1>", "intermittent", "features", "of", "a", "C0242422#ent", "<e2>", "like", "syndrome", "."], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [14, 15]}}
{"token": ["Both", "spontaneous", "and", "stimulus-evoked", "EPSPs", "were", "abolished", "or", "suppressed", "by", "addition", "of", "C0062637#ent", "<e1>", ",", "tetrodotoxin", ",", "or", "elevation", "of", "C1333909#ent", "<e2>", "+", "and", "reduction", "of", "Ca2", "+", "in", "the", "bathing", "medium"], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [20, 21]}}
{"token": ["Further", "clinical", "evaluation", ",", "however", ",", "that", "the", "patient", "had", "developed", "exogenous", "Cushing", "syndrome", "which", "presumably", "was", "caused", "by", "the", "inhibition", "of", "C1142644#ent", "<e1>", "metabolism", "of", "inhaled", "fluticasone", "the", "protease", "inhibitor", "C0292818#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [22, 23]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0292818", "name": "C0292818#ent", "pos": [31, 32]}}
{"token": ["Since", "AMD070", "is", "a", "substrate", "of", "C1142644#ent", "<e1>", "P-glycoprotein", ",", "both", "of", "which", "may", "be", "affected", "by", "C0292818#ent", "<e2>", ",", "we", "tested", "for", "a", "C0292818#ent", "<e2>", "effect", "on", "AMD070", "pharmacokinetics", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0292818", "name": "C0292818#ent", "pos": [17, 18]}}
{"token": ["Administration", "of", "C0011777#ent", "<e1>", "inhibited", "ACTH", "responses", "and", "did", "not", "inhibit", "C1419788#ent", "<e2>", "responses", "in", "both", "groups", "of", "ewes", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419788", "name": "C1419788#ent", "pos": [11, 12]}}
{"token": ["C0253239#ent", "<e1>", "(", "NAL", ")", "is", "a", "C0026698#ent", "<e2>", "anti-inflammatory", "and", "antioxidant", "properties", "and", "has", "been", "used", "clinically", "in", "CF", "patients", "to", "reduce", "mucus", "viscosity", "the", "airways", "."], "h": {"id": "C0253239", "name": "C0253239#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026698", "name": "C0026698#ent", "pos": [7, 8]}}
{"token": ["Recent", "efforts", "toward", "developing", "vaccines", "against", "group", "B", "streptococci", "C0018378#ent", "<e1>", ")", "have", "focused", "on", "increasing", "the", "immunogenicity", "of", "C0018378#ent", "<e1>", "C0032594#ent", "<e1>", "by", "conjugation", "to", "carrier", "proteins"], "h": {"id": "C0018378", "name": "C0018378#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [21, 22]}}
{"token": ["This", "is", "the", "first", "reported", "case", "of", "C1705280#ent", "<e1>", "due", "to", "hypokalemic", "rhabdomyolysis", "associated", "with", "C0268450#ent", "<e2>"], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268450", "name": "C0268450#ent", "pos": [15, 16]}}
{"token": ["This", "case", "report", "that", "C0068897#ent", "<e1>", "may", "induce", "NCSE", "in", "patients", "without", "C0014544#ent", "<e2>", "."], "h": {"id": "C0068897", "name": "C0068897#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [12, 13]}}
{"token": ["Carbamazepine", ",", "vigabatrin", ",", "gabapentine", ",", "C0068897#ent", "<e1>", ",", "phenytoin", "and", "phenobarbital", "are", "effective", "in", "C0014544#ent", "<e2>"], "h": {"id": "C0068897", "name": "C0068897#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [15, 16]}}
{"token": ["For", "all", "the", "C0080151#ent", "<e1>", ",", "apart", "from", "C1742019#ent", "<e2>", "5-hydroxyflunixin", ",", "mean", "recoveries", "ranging", "between", "69.0", "%", "and", "96.7", "%", "were", "measured", "."], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "silencing", "of", "other", "MAP3Ks", ",", "including", "MEKK1", ",", "MEKK3", ",", "NIK", ",", "and", "C1705156#ent", "<e1>", ",", "did", "not", "affect", "Tax-induced", "C1417708#ent", "<e2>", "activation", "."], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "optimal", "C1705156#ent", "<e1>", "stability", "in", "vivo", "interaction", "with", "ABIN-2", "as", "well", "as", "C1417708#ent", "<e2>", "."], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [14, 15]}}
{"token": ["Depletion", "of", "ABIN-2", "by", "RNA", "interference", "dramatically", "reduced", "steady-state", "levels", "of", "C1705156#ent", "<e1>", "affecting", "levels", "of", "TPL-2", "mRNA", "or", "C1417708#ent", "<e2>"], "h": {"id": "C1705156", "name": "C1705156#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [19, 20]}}
{"token": ["Finally", ",", "C1705526#ent", "<e1>", "transfected", "with", "wt", "p53", "were", "not", "significantly", "different", "from", "C1705526#ent", "<e1>", "cells", "with", "respect", "to", "sensitivity", "to", "C1420620#ent", "<e1>", "inhibitors", "or", "C1420620#ent", "<e1>", "levels", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [21, 22]}}
{"token": ["The", "role", "of", "C1705526#ent", "<e1>", "in", "altering", "C1420620#ent", "<e2>", "expression", "and", "chemosensitivity", "was", "studied", "in", "colorectal", "cancer", "cells", "wildtype", ",", "mutated", ",", "or", "functionally", "inactive", "C1705526#ent", "<e1>", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "functional", "inactivity", "mutations", "of", "C1705526#ent", "<e1>", "differentially", "affect", "C1420620#ent", "<e2>", ",", "potentially", "influencing", "response", "to", "C1420620#ent", "<e2>", "inhibitor-based", "treatment", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [10, 11]}}
{"token": ["Matrix", "metalloproteinase-9", "MMP-9", ")", "has", "a", "potential", "role", "in", "C0155760#ent", "<e1>", "but", "its", "relation", "to", "risk", "of", "C0010054#ent", "<e2>", "CHD", ")", "is", "uncertain", "."], "h": {"id": "C0155760", "name": "C0155760#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [17, 18]}}
{"token": ["To", "assess", "whether", "treatment", "of", "C0031090#ent", "<e1>", "plasma", "levels", "serum", "amyloid", "A", "SAA", ")", "and", "C1455838#ent", "<e2>", "PLTP", ")", "activity", "."], "h": {"id": "C0031090", "name": "C0031090#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1455838", "name": "C1455838#ent", "pos": [15, 16]}}
{"token": ["Major", "drawbacks", "of", "conventional", "models", "employing", "C0009325#ent", "<e1>", "hydrogels", "as", "dermal", "equivalents", "C0394006#ent", "<e2>", ")", ",", "are", "a", "rather", "poor", "stability", "limited", "life", "span", "restricting", "studies", "to", "early", "phases", "skin", "regeneration"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "that", "the", "PKC", "betaII", "peptide", "inhibitor", "attenuates", "PMN-induced", "post-I/R", "C0242350#ent", "<e1>", "increasing", "endothelial", "NO", "release", "and", "by", "inhibiting", "C0038838#ent", "<e2>", "release", "from", "PMNs", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "C3853563#ent", "<e1>", "and", "NH4Cl", "reduced", "the", "secretion", "of", "beta", "A4", "inhibiting", "C1569775#ent", "<e2>", "."], "h": {"id": "C3853563", "name": "C3853563#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1569775", "name": "C1569775#ent", "pos": [13, 14]}}
{"token": ["However", ",", "recent", "data", "suggest", "a", "continuous", "horizontal", "acquisition", "by", "S.", "aureus", "C3274839#ent", "<e1>", ",", "being", "unidirectional", "from", "CNS", "to", "C1825840#ent", "<e2>", "."], "h": {"id": "C3274839", "name": "C3274839#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [20, 21]}}
{"token": ["C0022265#ent", "<e1>", "not", "alter", "the", "increase", "in", "heart", "C1334332#ent", "<e2>", "activity", "observed", "with", "fasting", "."], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [8, 9]}}
{"token": ["In", "pups", "on", "C0733854#ent", "<e1>", "(", "composed", "of", "soybean", "oil", "C0885520#ent", "<e2>", "and", "glycerol", ")", ",", "mRNA", "was", "elevated", "at", "6", "h", "after", "ingestion", "."], "h": {"id": "C0733854", "name": "C0733854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0885520", "name": "C0885520#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "interventional", "studies", "chemokine", "and", "chemokine", "receptor", "antagonists", "that", "show", "the", "therapeutic", "potential", "of", "C3850102#ent", "<e1>", "experimental", "models", "lupus", "nephritis", "potentially", "in", "human", "C0035086#ent", "<e2>", "discussed", "."], "h": {"id": "C3850102", "name": "C3850102#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [24, 25]}}
{"token": ["The", "C2917660#ent", "<e1>", "divergence", "of", "the", "envelope", "(", "E", ")", "C0812324#ent", "<e2>", "the", "viruses", "was", "4.2", "%", "or", "less", "among", "the", "13", "strains", "compared", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812324", "name": "C0812324#ent", "pos": [10, 11]}}
{"token": ["The", "immunoreaction", "was", "carried", "out", "with", "an", "antiserum", "raised", "against", "a", "15", "C2917660#ent", "<e1>", "long", "synthetic", "peptide", "to", "the", "carboxy-terminus", "of", "potential", "C0812324#ent", "<e2>", "P1", ")", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812324", "name": "C0812324#ent", "pos": [22, 23]}}
{"token": ["This", "result", "supports", "the", "hypothesis", "that", "the", "C0016412#ent", "<e1>", "epileptics", "is", "caused", "by", "blocking", "the", "conversion", "of", "folic", "acid", "C2939773#ent", "<e2>", "phenytoin", "."], "h": {"id": "C0016412", "name": "C0016412#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C2939773", "name": "C2939773#ent", "pos": [19, 20]}}
{"token": ["C0016412#ent", "<e1>", "characterized", "by", "low", "cerebrospinal", "fluid", "CSF", ")", "concentrations", "of", "C2939773#ent", "<e2>", "and", "a", "broad", "spectrum", "of", "clinical", "signs", "symptoms", "."], "h": {"id": "C0016412", "name": "C0016412#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C2939773", "name": "C2939773#ent", "pos": [11, 12]}}
{"token": ["Controls", "were", "prospectively", "recruited", "from", "96", "patients", "attending", "a", "neurology", "clinic", "were", "interviewed", "to", "screen", "for", "C0001975#ent", "<e1>", "and", "substance", "use", "disorders", "other", "conditions", "possibly", "leading", "to", "C0235946#ent", "<e2>"], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0235946", "name": "C0235946#ent", "pos": [27, 28]}}
{"token": ["C0084866#ent", "<e1>", "treatment", "reduced", "TNF-alpha", ",", "C1968833#ent", "<e2>", ",", "CD40", ",", "and", "GFAP", "immunoreactivity", "in", "the", "lumbar", "spinal", "cord", "sections", "celastrol-treated", "G93A", "mice", "compared", "to", "untreated", "G93A", "mice", "."], "h": {"id": "C0084866", "name": "C0084866#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [6, 7]}}
{"token": ["C0084866#ent", "<e1>", "prevented", "not", "only", "LPS-induced", "mRNA", "expression", "of", "C1968833#ent", "<e2>", "and", "TNF-alpha", ",", "but", "also", "TNF-alpha-induced", "Bfl-1/A1", "expression", ",", "a", "prosurvival", "Bcl-2", "homologue"], "h": {"id": "C0084866", "name": "C0084866#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [9, 10]}}
{"token": ["Among", "them", "a", "lots", "of", "diseases", "are", "treatable", "dementia", ",", "like", "chronic", "subdural", "hematoma", "normal", "pressure", "hydrocephalus", "C0006105#ent", "<e1>", "syphilis", ",", "herpetic", "encephalitis", "Wilson's", "disease", "hypothyroidism", ",", "parathyroid", "disease", "C0042847#ent", "<e2>", "pellagra", "etc", "."], "h": {"id": "C0006105", "name": "C0006105#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0042847", "name": "C0042847#ent", "pos": [29, 30]}}
{"token": ["Mammalian", "C1825535#ent", "<e1>", "and", "HSP90beta", "are", "encoded", "by", "two", "individual", "C1417679#ent", "<e2>", "."], "h": {"id": "C1825535", "name": "C1825535#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["Sequence", "tagged", "sites", "STS", ")", "linkage", "analyses", "5", "megabases", "of", "C0087071#ent", "<e1>", "and", "centromeric", "DNA", "the", "C1366555#ent", "<e2>", "no", "allelic", "polymorphism", "between", "the", "two", "brothers", "."], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366555", "name": "C1366555#ent", "pos": [16, 17]}}
{"token": ["MeCP2", ",", "MBD1", ",", "C1417050#ent", "<e1>", ",", "MBD3", ",", "and", "MBD4", "comprise", "a", "family", "of", "C0086376#ent", "<e2>", "that", "contain", "a", "methyl-CpG", "binding", "domain", "MBD", ")", "."], "h": {"id": "C1417050", "name": "C1417050#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["Angiotensin", "converting", "enzyme", "inhibitors", "enalaprilat", "(", "3", "microM", ")", ",", "C0072970#ent", "<e1>", "(", "1", "microM", ")", "or", "C0065374#ent", "<e2>", "(", "1", "microM", ")", ",", "increased", "the", "bradykinin-induced", "renal", "vasodilation", "by", "40", "%", "or", "more", "."], "h": {"id": "C0072970", "name": "C0072970#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [17, 18]}}
{"token": ["Epidemiological", "evidence", "has", "raised", "concern", "that", "a", "moderate", "elevation", "in", "C1166521#ent", "<e1>", "stores", "may", "increase", "oxidative", "stress", "risk", "of", "C0018799#ent", "<e2>"], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [19, 20]}}
{"token": ["C0085292#ent", "<e1>", "SPS", ")", "is", "an", "immunologically", "mediated", "C0007682#ent", "<e2>", "is", "infrequently", "associated", "with", "malignancy", "."], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [8, 9]}}
{"token": ["Located", "within", "this", "region", "are", "the", "genes", "C1420399#ent", "<e1>", "(", "sterol", "regulatory", "element", "protein", "2", ")", "and", "C1417592#ent", "<e2>", "(", "N-acetyl-alpha-D-galactosaminidase", ")", "."], "h": {"id": "C1420399", "name": "C1420399#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417592", "name": "C1417592#ent", "pos": [17, 18]}}
{"token": ["Although", "GFP-PLD2", "localized", "to", "phagosomes", "and", "enhanced", "phagocytosis", ",", "C0388638#ent", "<e1>", "inhibition", "did", "not", "alter", "target", "ingestion", "or", "C3811758#ent", "<e2>", "localization", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811758", "name": "C3811758#ent", "pos": [18, 19]}}
{"token": ["PLC-beta", "stimulated", "by", "ET-1", ",", "may", "cross-talk", "with", "C0388638#ent", "<e1>", "via", "translocation", "of", "C3811758#ent", "<e2>", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3811758", "name": "C3811758#ent", "pos": [13, 14]}}
{"token": ["Al", "may", "inhibit", "C1705340#ent", "<e1>", "secretion", "in", "vitro", "however", ",", "induction", "of", "hypocalcemia", "can", "enhance", "endogenous", "C1705340#ent", "<e1>", "secretion", "in", "Al-loaded", "dogs", "and", "C1420583#ent", "<e1>", "patients", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420583", "name": "C1420583#ent", "pos": [23, 24]}}
{"token": ["Mutations", "in", "human", "C2986918#ent", "<e1>", "and", "PS2", "homologs", "are", "a", "cause", "of", "C0002395#ent", "<e2>", "AD", ")", "."], "h": {"id": "C2986918", "name": "C2986918#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [12, 13]}}
{"token": ["Acute", "toxicities", "grade", "3", "4", "C1568868#ent", "<e1>", "grade", "1", "2", "diarrhea", ",", "and", "C0015967#ent", "<e2>", "."], "h": {"id": "C1568868", "name": "C1568868#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [13, 14]}}
{"token": ["Chronic", "exposure", "to", "or", "0.5", "microM", "As(III", ")", "decreased", "c-Jun", ",", "c-Fos", "and", "C0140145#ent", "<e1>", "levels", "and", "C0162508#ent", "<e2>", "and", "NF-kappa", "B", "binding", "activity", "but", "increased", "Trx", "expression", "."], "h": {"id": "C0140145", "name": "C0140145#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "C0140145#ent", "<e1>", "significantly", "increased", "DNA", "binding", "Stat3", ",", "but", "not", "C0162508#ent", "<e2>", "."], "h": {"id": "C0140145", "name": "C0140145#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [12, 13]}}
{"token": ["5", ")", "Morbidity", "and", "mortality", "of", "C0020538#ent", "<e1>", "alleviated", "by", "C0008273#ent", "<e2>", "treatment", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0008273", "name": "C0008273#ent", "pos": [10, 11]}}
{"token": ["The", "investigation", "of", "oncogene", "expression", "for", "the", "myc", "and", "C0525678#ent", "<e1>", "families", "revealed", "the", "presence", "of", "myc", "p62", "C0525678#ent", "<e1>", "C3470429#ent", "<e1>", "oncoproteins", "in", "the", "tumor", "cells", "using", "monoclonal", "antibodies", "immunohistochemical", "tests"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [20, 21]}}
{"token": ["C1840333#ent", "<e1>", "also", "known", "as", "hypoparathyroidism", ",", "C0018784#ent", "<e2>", "and", "renal", "dysplasia", "syndrome", "an", "extremely", "rare", "congenital", "disorder"], "h": {"id": "C1840333", "name": "C1840333#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [7, 8]}}
{"token": ["C0027328#ent", "<e1>", "and", "MER-25", "mimicked", "the", "actions", "of", "estradiol", "and", "decreased", "C1416902#ent", "<e2>", "LPL", ")", "activity", "by", "75", "-", "80", "%", "."], "h": {"id": "C0027328", "name": "C0027328#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [11, 12]}}
{"token": ["Like", "C1332374#ent", "<e1>", ",", "these", "two", "C1417679#ent", "<e2>", ",", "designated", "BAI2", "and", "BAI3", ",", "were", "specifically", "expressed", "in", "brain", ",", "and", "are", "likely", "to", "be", "expressed", "in", "the", "same", "type", "of", "cells"], "h": {"id": "C1332374", "name": "C1332374#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}}
{"token": ["Other", "newly", "announced", "factors", "are", "also", "involved", "in", "p53-regulated", "apoptosis", "as", "C1332374#ent", "<e1>", "BSAI1", ")", ",", "MSOD", "and", "GPX", "C1417679#ent", "<e2>", "."], "h": {"id": "C1332374", "name": "C1332374#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [19, 20]}}
{"token": ["We", "retrospectively", "evaluated", "the", "efficacy", "of", "C0209368#ent", "<e1>", "MMF", ")", "in", "the", "treatment", "of", "steroid-resistant", "acute", "and", "C0018133#ent", "<e2>", "GVHD", ")", "after", "hematopoietic", "stem", "cell", "transplantation"], "h": {"id": "C0209368", "name": "C0209368#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018133", "name": "C0018133#ent", "pos": [17, 18]}}
{"token": ["Except", "for", "one", "patient", "with", "active", "lupus", "erythematosus", "developed", "C0022658#ent", "<e1>", "there", "was", "no", "evidence", "of", "an", "increase", "in", "C0409974#ent", "<e2>", "activity", "after", "immunization", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0409974", "name": "C0409974#ent", "pos": [19, 20]}}
{"token": ["C0854530#ent", "<e1>", "a", "common", "C0042769#ent", "<e2>", "by", "epidermal", "and/or", "mucosal", "vesicle", "formation", "."], "h": {"id": "C0854530", "name": "C0854530#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [4, 5]}}
{"token": ["This", "communication", "reports", "a", "68-year-old", "white", "man", "developed", "C0007785#ent", "<e1>", "as", "confusion", ",", "incoherence", ",", "disorientation", ",", "C0004134#ent", "<e2>", ",", "and", "numerous", "episodes", "of", "syncope", "daily", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [17, 18]}}
{"token": ["Similarly", ",", "IGF-IR", "and", "GHR", "mRNA", "expression", "were", "significantly", "increased", "by", "the", "lack", "of", "C0012177#ent", "<e1>", "whereas", "the", "levels", "of", "C1334089#ent", "<e2>", "mRNA", "remained", "unchanged", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [20, 21]}}
{"token": ["In", "chickens", "fed", "the", "control", "diet", "200", "g/kg", "C0012177#ent", "<e1>", "ad", "libitum", "7", "days", ",", "plasma", "C1334089#ent", "<e2>", "concentrations", "increased", "significantly", "from", "those", "found", "in", "the", "initial", "control", "group"], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [16, 17]}}
{"token": ["These", "observations", "suggest", "that", "the", "amino-terminal", "region", "G", "protein", "alpha", "subunits", "to", "the", "mastoparan-binding", "site", ",", "which", "may", "also", "be", "the", "C1709139#ent", "<e1>", "and", "is", "involved", "in", "regulation", "of", "C1414292#ent", "<e2>"], "h": {"id": "C1709139", "name": "C1709139#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1414292", "name": "C1414292#ent", "pos": [29, 30]}}
{"token": ["Spinal", "cord", "sections", "stained", "to", "detect", "hemorrhage", "(", "with", "hematoxylin", "and", "eosin", "[", "H&E", "]", ")", ",", "axonal", "injury", "with", "C1364818#ent", "<e1>", "betaAPP", "]", ")", ",", "and", "neuronal", "nuclei", "with", "C3146324#ent", "<e2>", ")", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3146324", "name": "C3146324#ent", "pos": [30, 31]}}
{"token": ["The", "effects", "of", "C0013617#ent", "<e1>", "were", "quickly", "reversible", "after", "the", "removal", "of", "the", "C1254351#ent", "<e2>", "from", "the", "bathing", "solution"], "h": {"id": "C0013617", "name": "C0013617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "either", "the", "COL4A3", "or", "the", "COL4A4", "genes", "encoding", "the", "alpha3", "and", "C1332774#ent", "<e1>", "are", "responsible", "for", "the", "autosomal-recessive", "form", "Alport", "syndrome", "a", "progressive", "C1567741#ent", "<e2>", "characterized", "by", "glomerular", "basement", "membrane", "abnormalities"], "h": {"id": "C1332774", "name": "C1332774#ent", "pos": [13, 14]}, "relation": "gene_associated_with_disease", "t": {"id": "C1567741", "name": "C1567741#ent", "pos": [25, 26]}}
{"token": ["In", "vitro", "studies", "have", "shown", "that", "the", "formation", "of", "3-hydroxyquinidine", "from", "C0034414#ent", "<e1>", "is", "catalyzed", "almost", "exclusively", "by", "C1142644#ent", "<e2>", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [11, 12]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [18, 19]}}
{"token": ["In", "vitro", "studies", "suggest", "that", "the", "oxidation", "of", "C0034414#ent", "<e1>", "to", "3-hydroxyquinidine", "is", "a", "specific", "marker", "reaction", "C1142644#ent", "<e2>", "activity", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [8, 9]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [17, 18]}}
{"token": ["However", ",", "sublingual", "application", "of", "the", "calcium", "antagonists", "simple", "and", "safe", ";", "moreover", ",", "C0028127#ent", "<e1>", "is", "better", "tolerated", "than", "nifedipine", "and", "C0009014#ent", "<e2>", "."], "h": {"id": "C0028127", "name": "C0028127#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [22, 23]}}
{"token": ["To", "evaluate", "and", "compare", "the", "efficacy", "and", "safety", "of", "fenofibrate", "and", "C0024027#ent", "<e1>", "in", "patients", "with", "type", "IIa", "C0020474#ent", "<e2>"], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020474", "name": "C0020474#ent", "pos": [18, 19]}}
{"token": ["Further", ",", "unlike", "purified", "mitochondria", "from", "wild", "type", "cells", "those", "obtained", "from", "resistant", "cells", "did", "not", "release", "cytochrome", "c", "apoptosis-inducing", "factor", "response", "to", "recombinant", "C0812198#ent", "<e1>", "or", "truncated", "C1332410#ent", "<e2>", "."], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1332410", "name": "C1332410#ent", "pos": [28, 29]}}
{"token": ["Furthermore", ",", "dominant", "negative", "C0812228#ent", "<e1>", "or", "active", "FOXO1", "constructs", "promote", "C1417023#ent", "<e2>", "precursor", "cell", "death", "a", "dominant", "negative", "FOXO1", "construct", "prevents", "cell", "death"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417023", "name": "C1417023#ent", "pos": [11, 12]}}
{"token": ["Interestingly", ",", "while", "biochemical", "results", "confirmed", "a", "decrease", "in", "C1704883#ent", "<e1>", "expression", ",", "an", "increase", "in", "C0919550#ent", "<e2>", "was", "observed", "."], "h": {"id": "C1704883", "name": "C1704883#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "using", "a", "recombinant", "C1704883#ent", "<e1>", "expressed", "in", "Escherichia", "coli", "demonstrated", "that", "C0919550#ent", "<e2>", "specifically", "cleaves", "C1704883#ent", "<e1>", "between", "Arg111-Tyr", "in", "vitro", "which", "resulted", "in", "a", "stimulation", "of", "progelatinase", "A-activation", "function", "."], "h": {"id": "C1704883", "name": "C1704883#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [13, 14]}}
{"token": ["Intracolonic", "administration", "of", "trinitrobenzene", "sulfonic", "acid", "TNBS", ")", "to", "rats", "produces", "C2826588#ent", "<e1>", "associated", "with", "increased", "release", "of", "eicosanoids", ",", "platelet-activating", "factor", "C0235480#ent", "<e2>", ")", ",", "and", "interleukins", "."], "h": {"id": "C2826588", "name": "C2826588#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [22, 23]}}
{"token": ["This", "study", "presents", "the", "clinical", "experience", "of", "myocardial", "revascularization", "4", "symptomatic", "C1956346#ent", "<e1>", "patients", "with", "unrepaired", "or", "corrected", "tetralogy", "of", "C1418436#ent", "<e2>", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418436", "name": "C1418436#ent", "pos": [20, 21]}}
{"token": ["These", "conditions", "include", "tumor", "growth", "retinopathies", ",", "hemangiomas", ",", "fibroses", ",", "and", "C0038013#ent", "<e1>", "the", "case", "of", "rampant", "C1522575#ent", "<e2>", "nonhealing", "wounds", "fractures", "in", "the", "case", "of", "inadequate", "C1522575#ent", "<e2>"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [18, 19]}}
{"token": ["Attempts", "were", "made", "to", "detect", "phenotypes", "of", "the", "C0031653#ent", "<e1>", "PGM", ")", "and", "C0031654#ent", "<e2>", "PGD", ")", "in", "human", "skin", "and", "adipose", "tissues"], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031654", "name": "C0031654#ent", "pos": [13, 14]}}
{"token": ["C0031653#ent", "<e1>", "had", "a", "higher", "heterozygosity", "than", "anodal", "malate", "dehydrogenase", "C0031654#ent", "<e2>"], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031654", "name": "C0031654#ent", "pos": [10, 11]}}
{"token": ["Gonorrhoea", "is", "probably", "the", "most", "commonly", "recognised", "STD", "in", "tropical", "Africa", "frequently", "causing", "epididymitis", "and", "C0041974#ent", "<e1>", "men", "and", "salpingitis", "and", "C0242172#ent", "<e2>", "women", "."], "h": {"id": "C0041974", "name": "C0041974#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0242172", "name": "C0242172#ent", "pos": [21, 22]}}
{"token": ["From", "these", "observations", ",", "a", "model", "describing", "the", "transport", "of", "water", "and", "osmotic", "substances", "the", "C0722058#ent", "<e1>", "was", "constructed", "to", "calculate", "the", "effect", "of", "C0071132#ent", "<e2>", "."], "h": {"id": "C0722058", "name": "C0722058#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0071132", "name": "C0071132#ent", "pos": [24, 25]}}
{"token": ["The", "modeling", "approach", "used", "in", "C0769345#ent", "<e1>", "was", "similar", "to", "that", "used", "2", "years", "ago", "in", "C1437927#ent", "<e2>", "(", "Venclovas", ",", "Proteins", "2001", ";", "Suppl", "5:47", "-", "54", ")", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1437927", "name": "C1437927#ent", "pos": [16, 17]}}
{"token": ["Interferon-gamma", "strongly", "induced", "CASP1", "and", "C0769345#ent", "<e1>", "but", "not", "C1437927#ent", "<e2>", "or", "CASP13", "gene", "in", "HT-29", "colon", "carcinoma", "cells", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1437927", "name": "C1437927#ent", "pos": [9, 10]}}
{"token": ["Of", "over", "50", "maternal", "factors", "studied", "the", "following", "showed", "significant", "association", "with", "NTD", "in", "the", "offspring", ":", "diabetes", "mellitus", "organic", "heart", "disease", "C0024115#ent", "<e1>", "and", "diuretic", ",", "antihistamine", ",", "and", "C0038760#ent", "<e2>"], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [30, 31]}}
{"token": ["The", "most", "frequent", "reports", "were", "coughing", "caused", "by", "ACE", "inhibitors", "attack", "of", "bronchial", "asthma", "induced", "by", "nonsteroidal", "anti-inflammatory", "drugs", "beta-blocking", "agents", "C0024115#ent", "<e1>", "by", "amiodarone", "and", "C0038760#ent", "<e2>", ",", "and", "respiratory", "depression", "to", "benzodiazepines", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [26, 27]}}
{"token": ["The", "M3-selective", "antagonists", ",", "4-DAMP", "and", "C0529351#ent", "<e1>", "had", "high", "affinities", "(", "C1705341#ent", "<e2>", "values", "of", "9.4", "and", "8.6", ",", "respectively", ")", "."], "h": {"id": "C0529351", "name": "C0529351#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [12, 13]}}
{"token": ["We", "report", "an", "unusual", "case", "of", "multiple", "sulfatase", "deficiency", "which", "neurodegeneration", "was", "accompanied", "by", "early", ",", "severe", "visual", "impairment", "associated", "with", "C0035334#ent", "<e1>", "suggesting", "a", "diagnosis", "of", "C1332805#ent", "<e2>"], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1332805", "name": "C1332805#ent", "pos": [27, 28]}}
{"token": ["The", "neuroprotective", "action", "insulin-like", "growth", "factor", "I", "C1334089#ent", "<e1>", ")", "was", "tested", "in", "immortalized", "hypothalamic", "C3537450#ent", "<e2>", "-", "7", "cells", "exposed", "to", "reduced", "glutathione", "depleting", "agents", ",", "which", "cause", "oxidative", "stress", "cell", "death"], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537450", "name": "C3537450#ent", "pos": [15, 16]}}
{"token": ["The", "expression", "of", "the", "C1335440#ent", "<e1>", "E.", "coli", "achieved", "by", "inserting", "the", "C0017337#ent", "<e2>", "before", "the", "tac", "promoter", "of", "the", "pKK223", "-", "3", "plasmid", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["T5", "5'-3'-exonuclease", "many", "similarities", "with", "the", "amino", "terminal", "of", "eubacterial", "DNA", "polymerases", "although", ",", "unlike", "eubacteria", ",", "phages", "such", "as", "T5", ",", "T4", "and", "T7", "express", "C1335440#ent", "<e1>", "and", "5'-exonuclease", "proteins", "separate", "C0017337#ent", "<e2>", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [32, 33]}}
{"token": ["With", "the", "exception", "of", "one", "mutation", "in", "the", "X", "gene", "all", "were", "located", "in", "the", "C1335440#ent", "<e1>", "suggesting", "this", "C0017337#ent", "<e2>", "plays", "a", "critical", "role", "in", "clinical", "outcome"], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["It", "also", "inhibits", "gastric", "acid", "secretion", "evoked", "by", "C0283886#ent", "<e1>", "(", "a", "stable", "analog", "of", "C1421143#ent", "<e2>", "the", "putative", "mediator", "of", "cold-restraint", "stress", "ulcers", "."], "h": {"id": "C0283886", "name": "C0283886#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [15, 16]}}
{"token": ["Glutathione", ",", "glutathione", "S-transferases", "alpha", "pi", ",", "and", "C0684287#ent", "<e1>", "associated", "with", "resistance", "to", "carboplatin", "and/or", "C0010583#ent", "<e2>", "in", "cell", "lines"], "h": {"id": "C0684287", "name": "C0684287#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [16, 17]}}
{"token": ["Similarly", ",", "C0684287#ent", "<e1>", "an", "enzyme", "important", "in", "the", "metabolic", "pathway", "C0010583#ent", "<e2>", "has", "been", "implicated", "as", "being", "important", "in", "the", "protection", "of", "hematopoietic", "cells", "4-hydroperoxycyclophosphamide", "."], "h": {"id": "C0684287", "name": "C0684287#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [11, 12]}}
{"token": ["The", "line", "selected", "for", "resistance", "to", "C0039902#ent", "<e1>", "had", "low", "guanine", "phosphoribosyltransferase", "activity", "guanosine", "monophosphate", "C0002492#ent", "<e2>", "EC", "2.4.2.8", "and", "was", "deficient", "in", "activity", "for", "xanthine", "and", "C0039902#ent", "<e1>", "."], "h": {"id": "C0002492", "name": "C0002492#ent", "pos": [15, 16]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [6, 7]}}
{"token": ["Glomerular", "expression", "VEGF", ",", "TGF-beta1", ",", "and", "C1413791#ent", "<e1>", ",", "the", "amount", "of", "C1420369#ent", "<e2>", "and", "glomerular", "ECM", "were", "measured", "on", "the", "seventh", "disease", "day", "."], "h": {"id": "C1413791", "name": "C1413791#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [13, 14]}}
{"token": ["With", "the", "addition", "of", "C0005223#ent", "<e1>", "to", "the", "test", "medium", "cycasin", "elicited", "C1333237#ent", "<e2>", "clear", "dependence", "on", "both", "dose", "and", "amount", "of", "C0005223#ent", "<e1>", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [4, 5]}}
{"token": ["Although", "phosphorylated", "C1705506#ent", "<e1>", "remains", "bound", "to", "the", "active", "p50-RelA/p65", "heterodimer", "of", "NF-kappaB", ",", "derepression", "of", "C1705506#ent", "<e1>", "is", "evidenced", "by", "the", "loss", "of", "chromatin-associated", "C1366355#ent", "<e1>", "activity", "."], "h": {"id": "C1705506", "name": "C1705506#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366355", "name": "C1366355#ent", "pos": [25, 26]}}
{"token": ["C0010674#ent", "<e1>", "an", "hereditary", "disease", "which", "abnormally", "viscous", "secretion", "exocrine", "glands", "chronic", "pulmonary", "infections", "C0017178#ent", "<e2>"], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [14, 15]}}
{"token": ["Vasospasms", "are", "not", "only", "present", "in", "Raynaud's", "disease", "migraine", ",", "Prinzmetal's", "variant", "angina", "visual", "field", "defects", "partially", "in", "C0152136#ent", "<e1>", "but", "may", "also", "be", "involved", "in", "the", "pathogenesis", "of", "C0156147#ent", "<e2>"], "h": {"id": "C0152136", "name": "C0152136#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [29, 30]}}
{"token": ["This", "mutation", "in", "C1412335#ent", "<e1>", "genes", "may", "cause", "inactivation", "of", "ALDR", "activity", "in", "C1419876#ent", "<e2>", "and", "LEA", "rats", "."], "h": {"id": "C1412335", "name": "C1412335#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419876", "name": "C1419876#ent", "pos": [13, 14]}}
{"token": ["Thirty", "patients", "with", "C0009766#ent", "<e1>", "caused", "by", "Parietaria", "or", "grass", "pollens", "participated", "in", "a", "double-blind", "parallel", "study", "C0064870#ent", "<e2>", "to", "cromolyn", "sodium", "both", "given", "as", "eye", "drops"], "h": {"id": "C0009766", "name": "C0009766#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0064870", "name": "C0064870#ent", "pos": [17, 18]}}
{"token": ["The", "hammerhead", "ribozyme", "a", "more", "efficient", "C0035542#ent", "<e1>", "than", "an", "C0032589#ent", "<e2>"], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032589", "name": "C0032589#ent", "pos": [10, 11]}}
{"token": ["Cells", "treated", "with", "x", "10", "-", "8", "m", "C0011777#ent", "<e1>", "in", "vitro", "expressed", "maximal", "levels", "of", "C1705281#ent", "<e2>", "after", "6", "days", ",", "with", "an", "approximately", "3-fold", "increase", "over", "C1705281#ent", "<e2>", "levels", "on", "untreated", "cells", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [16, 17]}}
{"token": ["We", "studied", "the", "effects", "of", "C0011777#ent", "<e1>", "on", "biosynthesis", "of", "mucin", "and", "C1705281#ent", "<e2>", "gene", "expression", "the", "human", "stomach", "in", "vitro"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [12, 13]}}
{"token": ["The", "finding", "that", "the", "C0042397#ent", "<e1>", "respiratory", "acidosis", "enhanced", "during", "beta-adrenergic", "blockade", "that", "C4255305#ent", "<e2>", "alpha-receptors", "may", "be", "unmasked", "during", "beta-adrenergic", "blockade"], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [13, 14]}}
{"token": ["The", "effectiveness", "of", "the", "C0042397#ent", "<e1>", "not", "necessarily", "due", "to", "a", "primary", "C4255305#ent", "<e2>", "action", "on", "arteries", "and", "arterioles", ",", "as", "previously", "assumed", "."], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [12, 13]}}
{"token": ["Addition", "of", "C1538124#ent", "<e1>", "catalyzed", "a", "net", "transfer", "of", "C3810569#ent", "<e2>", "*", "from", "donor", "to", "acceptor", "vesicles"], "h": {"id": "C1538124", "name": "C1538124#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [9, 10]}}
{"token": ["This", "was", "also", "observed", "when", "micelles", "of", "lysophosphatidylcholine", "and", "vesicles", "of", "phosphatidic", "acid", "added", ",", "indicating", "that", "the", "C1538124#ent", "<e1>", "insert", "its", "endogenous", "C3810569#ent", "<e2>", "*", "into", "interfaces", "devoid", "of", "phosphatidylcholine", "."], "h": {"id": "C1538124", "name": "C1538124#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [23, 24]}}
{"token": ["The", "remaining", "five", "low-flow", "C0029899#ent", "<e1>", "patients", "had", "reduced", "blood", "volume", "increased", "C3273406#ent", "<e2>", "was", "not", "correlated", "with", "blood", "volume"], "h": {"id": "C0029899", "name": "C0029899#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [12, 13]}}
{"token": ["C0241910#ent", "<e1>", "AIH", ")", "is", "also", "more", "prevalent", "in", "patients", "with", "C0022104#ent", "<e2>", ",", "with", "up", "to", "16", "%", "of", "patients", "with", "AIH", "also", "having", "ulcerative", "colitis"], "h": {"id": "C0241910", "name": "C0241910#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [11, 12]}}
{"token": ["Amiodarone-induced", "thyrotoxicosis", "C1426025#ent", "<e1>", ")", "type", "1", "occurs", "in", "subjects", "with", "an", "underlying", "C0040128#ent", "<e2>", "whereas", "type", "2", "AIT", "a", "form", "of", "destructive", "thyroiditis"], "h": {"id": "C1426025", "name": "C1426025#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [13, 14]}}
{"token": ["A", "6-year-old", "girl", "with", "a", "progressive", "syndrome", "of", "C0029124#ent", "<e1>", "ataxia", ",", "myoclonic", "epilepsy", "urinary", "incontinence", "and", "pyramidal", "tract", "degeneration", "suggestive", "of", "C0221061#ent", "<e2>", "described", "."], "h": {"id": "C0029124", "name": "C0029124#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0221061", "name": "C0221061#ent", "pos": [22, 23]}}
{"token": ["To", "assess", "whether", "there", "might", "be", "an", "association", "between", "C0950124#ent", "<e1>", "GPVI", ")", "and", "C0004691#ent", "<e2>", "."], "h": {"id": "C0950124", "name": "C0950124#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004691", "name": "C0004691#ent", "pos": [14, 15]}}
{"token": ["These", "results", "demonstrate", "that", "the", "progression", "of", "C0242337#ent", "<e1>", "PL", "is", "associated", "with", "reduced", "expression", "of", "classical", "C3540579#ent", "<e2>", "and", "Th2", "cytokines", "by", "CD4+", "T", "cells", "thus", "suggesting", "aberrant", "Th", "regulation", "subclinically", "infected", "animals", "."], "h": {"id": "C0242337", "name": "C0242337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [17, 18]}}
{"token": ["C1414352#ent", "<e1>", "was", "also", "phosphorylated", "at", "a", "significant", "rate", "by", "casein", "kinase", "II", "C0033640#ent", "<e2>", "investigate", "sites", "of", "phosphorylation", ",", "C1414352#ent", "<e1>", "was", "digested", "with", "collagenase", "and", "phosphopeptides", "were", "resolved", "by", "reverse", "phase", "high", "performance", "liquid", "chromatography"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414352", "name": "C1414352#ent", "pos": [0, 1]}}
{"token": ["Adhesion", "of", "cultured", "endothelial", "cells", "partly", "abrogated", "by", "C1420342#ent", "<e1>", "and", "was", "correspondingly", "reversed", "by", "C1336937#ent", "<e2>", "in", "a", "concentration-dependent", "manner", "."], "h": {"id": "C1420342", "name": "C1420342#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1336937", "name": "C1336937#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "C1538607#ent", "<e1>", "is", "called", "C0251914#ent", "<e2>"], "h": {"id": "C1538607", "name": "C1538607#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0251914", "name": "C0251914#ent", "pos": [6, 7]}}
{"token": ["These", "results", "indicate", "that", "C1538607#ent", "<e1>", "comprise", "a", "group", "of", "C0251914#ent", "<e2>", "show", "thiol", "group-related", "proteolytic", "activity"], "h": {"id": "C1538607", "name": "C1538607#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0251914", "name": "C0251914#ent", "pos": [10, 11]}}
{"token": ["Intrathecally", "administered", "C0733398#ent", "<e1>", ",", "an", "alpha-adrenoceptor", "antagonist", "attenuated", "and", "desipramine", ",", "a", "C1579361#ent", "<e2>", "augmented", "the", "antinociceptive", "effect", "of", "R-84760", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1579361", "name": "C1579361#ent", "pos": [13, 14]}}
{"token": ["Beta-Galactosidase", "was", "partially", "restored", "by", "protease", "inhibitors", "leupeptin", ",", "chymostatin", "and", "C0058882#ent", "<e1>", "in", "cultured", "fibroblasts", "from", "three", "patients", "with", "C0085131#ent", "<e2>"], "h": {"id": "C0058882", "name": "C0058882#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085131", "name": "C0085131#ent", "pos": [20, 21]}}
{"token": ["Little", "is", "known", "about", "the", "effects", "of", "C0003277#ent", "<e1>", "hypercholesterolemic", "patients", "with", "C0008312#ent", "<e2>", "PBC", ")", "."], "h": {"id": "C0003277", "name": "C0003277#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [12, 13]}}
{"token": ["No", "detectable", "inorganic", "or", "C1709420#ent", "<e1>", "adenylate", "kinase", "almost", "negligible", "activities", "of", "mitochondrial", "ATPase", "of", "other", "C0031678#ent", "<e2>", "are", "present", "in", "this", "preparation", "."], "h": {"id": "C1709420", "name": "C1709420#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031678", "name": "C0031678#ent", "pos": [16, 17]}}
{"token": ["DNA", "sequence", "analysis", "a", "portion", "of", "this", "clone", "confirmed", "the", "presence", "of", "C0017337#ent", "<e1>", "for", "the", "C0599874#ent", "<e2>", "as", "well", "as", "C0017337#ent", "<e1>", "encoding", "a", "dehydrogenase", "and", "putative", "aldolase"], "h": {"id": "C0599874", "name": "C0599874#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["Severe", "C0020625#ent", "<e1>", "has", "been", "observed", "in", "three", "children", "with", "C0002895#ent", "<e2>", "and", "mild", "hyponatremia", "noted", "during", "36", "%", "of", "random", "hospitalizations", "sickle", "crisis", "secondary", "to", "or", "infection", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [10, 11]}}
{"token": ["Particularly", "difficult", "causes", "and", "concepts", "of", "C0020625#ent", "<e1>", "are", "the", "syndrome", "of", "inappropriate", "antidiuresis", "and", "the", "C0002895#ent", "<e2>", "which", "are", "discussed", "here", "in", "detail", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [16, 17]}}
{"token": ["We", "then", "analysed", "the", "available", "single-nucleotide", "polymorphisms", "SNPs", ")", "present", "at", "high", "frequencies", "in", "the", "general", "population", "spreading", "throughout", "the", "FECH", ",", "HMBS", ",", "C3811761#ent", "<e1>", "and", "the", "CPO", "C0017337#ent", "<e2>", "in", "four", "case-control", "association", "studies"], "h": {"id": "C3811761", "name": "C3811761#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [29, 30]}}
{"token": ["The", "C1334910#ent", "<e1>", "a", "partner", "of", "the", "Tel-TrkC", "(", "C3275265#ent", "<e2>", ")", "chimeric", "tyrosine", "kinase", "a", "potent", "oncoprotein", "expressed", "in", "tumors", "derived", "from", "multiple", "cell", "lineages"], "h": {"id": "C1334910", "name": "C1334910#ent", "pos": [1, 2]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3275265", "name": "C3275265#ent", "pos": [9, 10]}}
{"token": ["Third", ",", "after", "intracerebral", "injection", "in", "living", "transgenic", "mouse", "models", "of", "C0268381#ent", "<e1>", "BSB", "labels", "C1843919#ent", "<e2>", "composed", "of", "human", "Abeta", "with", "high", "sensitivity", "specificity", "."], "h": {"id": "C0268381", "name": "C0268381#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1843919", "name": "C1843919#ent", "pos": [15, 16]}}
{"token": ["a", "control", "diet", "(", "g/kg", ")", "150", "protein", "(", "C1704968#ent", "<e1>", ")", ",", "or", "a", "diet", "containing", "50", "protein", "(", "C1538611#ent", "<e2>", ")", "or", "450", "protein", "(", "P45", ")", "."], "h": {"id": "C1704968", "name": "C1704968#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1538611", "name": "C1538611#ent", "pos": [20, 21]}}
{"token": ["Of", "four", "T", "cell", "lines", "two", "recognized", "C1704968#ent", "<e1>", "and", "two", "recognized", "C1538611#ent", "<e2>", "."], "h": {"id": "C1704968", "name": "C1704968#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538611", "name": "C1538611#ent", "pos": [12, 13]}}
{"token": ["However", ",", "VEGF164", "increased", "its", "expression", "2-folds", "at", "C1704968#ent", "<e1>", "in", "comparison", "to", "C1538611#ent", "<e2>", ",", "remaining", "at", "this", "level", "in", "the", "adult", "brain", "(", "P30", ")", "."], "h": {"id": "C1704968", "name": "C1704968#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538611", "name": "C1538611#ent", "pos": [13, 14]}}
{"token": ["Total", "levels", "of", "C1428067#ent", "<e1>", "activity", "and", "asymmetric", "N(G", ",", "C0067385#ent", "<e2>", "were", "reduced", "by", "85", "and", "54", "%", ",", "respectively", ",", "while", "levels", "of", "hypomethylated", "substrates", "were", "increased", "15-fold", "."], "h": {"id": "C1428067", "name": "C1428067#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0067385", "name": "C0067385#ent", "pos": [10, 11]}}
{"token": ["PRMT5", "is", "the", "first", "example", "of", "a", "catalytic", "chain", "a", "C1428067#ent", "<e1>", "can", "result", "in", "the", "formation", "of", "C0067385#ent", "<e2>", "observed", "previously", "in", "myelin", "basic", "protein", "Sm", "small", "nuclear", "ribonucleoproteins", "and", "other", "polypeptides", "."], "h": {"id": "C1428067", "name": "C1428067#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0067385", "name": "C0067385#ent", "pos": [18, 19]}}
{"token": ["The", "hypocholesterolemic", "and", "adverse", "effects", "C0009279#ent", "<e1>", ",", "20", "g/day", ",", "and", "C0009279#ent", "<e1>", ",", "10", "g/day", "combined", "with", "C0033215#ent", "<e1>", ",", "1", "g/day", ",", "were", "compared", "."], "h": {"id": "C0009279", "name": "C0009279#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033215", "name": "C0033215#ent", "pos": [19, 20]}}
{"token": ["Agents", "modeled", "were", "cholestyramine", ",", "C0009279#ent", "<e1>", ",", "gemfibrozil", ",", "lovastatin", ",", "niacin", ",", "and", "C0033215#ent", "<e2>", "."], "h": {"id": "C0009279", "name": "C0009279#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033215", "name": "C0033215#ent", "pos": [15, 16]}}
{"token": ["Lovastatin", "plus", "C0009279#ent", "<e1>", "lowered", "LDL", "52", "%", ";", "C0033215#ent", "<e2>", "added", "as", "a", "third", "agent", "no", "further", "lowering", "."], "h": {"id": "C0009279", "name": "C0009279#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033215", "name": "C0033215#ent", "pos": [9, 10]}}
{"token": ["Cell", "shrinkage", "in", "monkey", "lateral", "geniculate", "nucleus", "C1428865#ent", "<e1>", ")", "layers", "supplied", "by", "the", "C0002418#ent", "<e2>", "eye", "have", "been", "described", "in", "experimental", "amblyopia", "caused", "by", "visual", "deprivation", "anisometropia", ",", "and", "strabismus", "."], "h": {"id": "C1428865", "name": "C1428865#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002418", "name": "C0002418#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "E2", "and", "overexpressed", "C1414462#ent", "<e1>", "downregulated", "the", "C1332803#ent", "<e2>", "cause", "the", "downregulation", "of", "its", "target", "genes", ",", "cyclin", "D1", "Rb", ",", "to", "inhibit", "the", "cell", "cycle", "cell", "proliferation"], "h": {"id": "C1414462", "name": "C1414462#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [10, 11]}}
{"token": ["To", "compare", "a", "topical", "quinolone", "antibiotic", "C0008809#ent", "<e1>", ")", "with", "a", "cheaper", "topical", "antiseptic", "boric", "acid", "for", "treating", "C0271454#ent", "<e2>", "in", "children", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0271454", "name": "C0271454#ent", "pos": [18, 19]}}
{"token": ["In", "order", "to", "evaluate", "the", "susceptibility", "of", "the", "microorganisms", "isolated", "from", "C0271454#ent", "<e1>", "to", "C0008809#ent", "<e2>", ",", "cultures", "of", "specimens", "from", "127", "patients", "with", "C0271454#ent", "<e1>", "and", "their", "antibiotic", "sensitivity", "results", "were", "examined", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0271454", "name": "C0271454#ent", "pos": [11, 12]}}
{"token": ["When", "this", "C1428707#ent", "<e1>", "was", "intermittently", "displaced", "into", "the", "left", "upper", "abdomen", ",", "C0042961#ent", "<e2>", "of", "both", "the", "stomach", "and", "transverse", "colon", "."], "h": {"id": "C1428707", "name": "C1428707#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042961", "name": "C0042961#ent", "pos": [13, 14]}}
{"token": ["In", "Escherichia", "coli", "reactivation", "of", "C0035547#ent", "<e1>", "achieved", "by", "reduced", "flavins", "produced", "by", "C0030016#ent", "<e2>"], "h": {"id": "C0035547", "name": "C0035547#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [13, 14]}}
{"token": ["Streptococcus", "mutans", "the", "major", "pathogen", "of", "C0011334#ent", "<e1>", "a", "biofilm-dependent", "infectious", "disease", ",", "and", "occasionally", "causes", "C0014121#ent", "<e2>"], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [16, 17]}}
{"token": ["The", "molecular", "defect", "C1421374#ent", "<e1>", "UROD", ")", "was", "examined", "in", "a", "patient", "with", "C0162569#ent", "<e2>"], "h": {"id": "C1421374", "name": "C1421374#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0162569", "name": "C0162569#ent", "pos": [13, 14]}}
{"token": ["This", "study", "examines", "the", "activity", "and", "safety", "of", "subcutaneously", "injected", "C1174289#ent", "<e1>", "in", "patients", "with", "type", "2", "diabetes", "treated", "with", "diet", "and/or", "C0935929#ent", "<e2>", "OAAs", ")", "."], "h": {"id": "C1174289", "name": "C1174289#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [22, 23]}}
{"token": ["Nonsteroidal", "anti-inflammatory", "drugs", "NSAIDs", ")", "are", "used", "to", "reduce", "inflammation", "and", "as", "C0728960#ent", "<e1>", "by", "inhibition", "of", "C0387583#ent", "<e2>", "."], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [17, 18]}}
{"token": ["Levels", "of", "C3274855#ent", "<e1>", "mRNA", "markedly", "increased", "during", "megakaryocytic", "differentiation", "both", "C1707170#ent", "<e2>", "megakaryoblasts", "as", "well", "as", "normal", "CD34(+", ")", "hematopoietic", "stem", "cells", "."], "h": {"id": "C3274855", "name": "C3274855#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1707170", "name": "C1707170#ent", "pos": [11, 12]}}
{"token": ["Human", "autosomal", "dominant", "C0022680#ent", "<e1>", "ADPKD", ")", "is", "a", "common", "inherited", "disease", "displays", "a", "gender", "dimorphism", "C0022658#ent", "<e2>", "progression", "."], "h": {"id": "C0022680", "name": "C0022680#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [16, 17]}}
{"token": ["Glomerulonephritis", ",", "pyelonephritis", ",", "diabetic", "nephropathy", "and", "C0022680#ent", "<e1>", "the", "four", "most", "frequent", "original", "C0022658#ent", "<e2>", "to", "altogether", "500", "kidney", "transplantations", "Rostock", "from", "1976", "to", "1989", "."], "h": {"id": "C0022680", "name": "C0022680#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [14, 15]}}
{"token": ["Lethal", "3", "malignant", "brain", "tumor", "1", "C1423822#ent", "<e1>", ")", ",", "a", "homolog", "of", "the", "Drosophila", "polycomb", "C0079427#ent", "<e2>", ",", "contains", "three", "tandem", "MBT", "repeats", "3xMBT", ")", "that", "are", "critical", "for", "transcriptional", "repression"], "h": {"id": "C1423822", "name": "C1423822#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [16, 17]}}
{"token": ["The", "inhibitory", "effect", "of", "PA", "may", "have", "been", "due", "to", "PA", "binding", "to", "the", "C0012177#ent", "<e1>", "to", "the", "rumen", "proteases", "interfering", "with", "the", "action", "of", "C0030940#ent", "<e2>", "on", "susceptible", "sites", "the", "substrate", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [25, 26]}}
{"token": ["A", "case", "of", "chronic", "intermediate", "uveitis", "associated", "classic", "snowbanking", "(", "C0030593#ent", "<e1>", "with", "severe", "cystoid", "macular", "oedema", "due", "to", "C0024198#ent", "<e2>", "reported", "."], "h": {"id": "C0030593", "name": "C0030593#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024198", "name": "C0024198#ent", "pos": [19, 20]}}
{"token": ["The", "relationships", "between", "the", "C1335265#ent", "<e1>", "and", "LEP", "genotypes", "and", "TBN", ",", "C1842690#ent", "<e2>", "and", "NW", "were", "analysed", "."], "h": {"id": "C1335265", "name": "C1335265#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1842690", "name": "C1842690#ent", "pos": [12, 13]}}
{"token": ["C0035541#ent", "<e1>", "indicate", "that", "four", "major", "classes", "of", "C1708016#ent", "<e2>", "at", "heterogeneous", "cap", "sites", "two", "distinct", "promoter", "regions", "P1", "and", "P2", ",", "spanning", "approximately", "50", "and", "150", "bp", "respectively", "."], "h": {"id": "C0035541", "name": "C0035541#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1708016", "name": "C1708016#ent", "pos": [8, 9]}}
{"token": ["We", "investigated", "changes", "of", "abundantly", "expressed", "mRNAs", "of", "two", "transmembrane", "protein", "tyrosine", "phosphatases", "C1419111#ent", "<e1>", "(", "leukocyte", "common", "antigen-related", "phosphatase", ")", "and", "C1419124#ent", "<e2>", "."], "h": {"id": "C1419111", "name": "C1419111#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1419124", "name": "C1419124#ent", "pos": [22, 23]}}
{"token": ["The", "authors", "conclude", "that", "defective", "ventilatory", "responses", "hypoxemia", "or", "hypercarbia", "are", "not", "associated", "with", "C3814825#ent", "<e1>", "diabetics", "with", "C0259749#ent", "<e2>"], "h": {"id": "C3814825", "name": "C3814825#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0259749", "name": "C0259749#ent", "pos": [18, 19]}}
{"token": ["C0031441#ent", "<e1>", ",", "an", "alpha-adrenergic", "receptor", "antagonists", "and", "C0021246#ent", "<e2>", "prevented", "phenylephrine-induced", "PG", "release", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [8, 9]}}
{"token": ["Some", "C0012634#ent", "<e1>", "which", "imitate", "an", "accelerated", "aging", "as", "Progeria", "and", "the", "C1337007#ent", "<e2>", "due", "to", "mutations", ",", "some", "of", "them", "mutagenic", "themselves", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1337007", "name": "C1337007#ent", "pos": [12, 13]}}
{"token": ["The", "human", "C0012634#ent", "<e1>", "and", "Bloom", "syndromes", "a", "result", "of", "mutation", "of", "the", "C1337007#ent", "<e2>", "and", "BLM", "genes", ",", "respectively", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1337007", "name": "C1337007#ent", "pos": [13, 14]}}
{"token": ["Fatigue", "is", "a", "frequent", "and", "C3714552#ent", "<e1>", "symptom", "in", "patients", "with", "C0008312#ent", "<e2>", "PBC", ")", "."], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "combined", "effects", "of", "the", "chemotactic", "peptide", "n-formyl-methionyl-leucyl-phenylalanine", "C1705725#ent", "<e1>", ")", "and", "phorbol", "myristate", "acetate", "PMA", ")", "on", "C1259877#ent", "<e2>", "PKC", ")", "activity", "in", "human", "neutrophils", "."], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [20, 21]}}
{"token": ["Incubation", "of", "human", "neutrophils", "with", "C1705725#ent", "<e1>", ",", "a", "chemotactic", "peptide", "or", "PMA", ",", "a", "stimulator", "of", "C1259877#ent", "<e2>", "resulted", "in", "the", "activation", "of", "p38", ",", "a", "proline-directed", "kinase"], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [17, 18]}}
{"token": ["However", ",", "these", "features", "may", "also", "be", "caused", "by", "C0027765#ent", "<e1>", "in", "the", "elderly", ",", "such", "as", "dementia", "or", "C0037928#ent", "<e2>", "which", "is", "very", "common", "after", "75", "years", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0037928", "name": "C0037928#ent", "pos": [19, 20]}}
{"token": ["Therefore", "the", "results", "of", "the", "present", "study", "are", "consistent", "with", "hypothesis", "that", "astroglial", "cells", "be", "involved", "in", "demyelination", "processes", "occurring", "in", "the", "HTLV-I", "associated", "C0027765#ent", "<e1>", "such", "as", "human", "associated", "C0037928#ent", "<e2>", "and", "tropical", "spastic", "paraparesis"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [24, 25]}, "relation": "related_to", "t": {"id": "C0037928", "name": "C0037928#ent", "pos": [30, 31]}}
{"token": ["In", "the", "unirradiated", "rat", "spinal", "cord", "there", "was", "no", "evidence", "of", "C1412332#ent", "<e1>", "immunoreactivity", "and", "little", "evidence", "of", "C1522575#ent", "<e2>", "expression", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [18, 19]}}
{"token": ["RNF11", "has", "been", "shown", "to", "interact", "with", "HECT-type", "E3", "ubiquitin", "ligases", "Nedd4", ",", "AIP4", ",", "Smurf1", "and", "C4049869#ent", "<e1>", ",", "as", "well", "as", "with", "C1413217#ent", "<e2>", ",", "the", "core", "protein", "the", "multi-subunit", "SCF", "E3", "ubiquitin", "ligase", "complex"], "h": {"id": "C4049869", "name": "C4049869#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413217", "name": "C1413217#ent", "pos": [24, 25]}}
{"token": ["Fourteen", "patients", "aged", "4.9", "to", "21.5", "years", "with", "C0010674#ent", "<e1>", "moderate", "to", "severe", "lung", "disease", "malnutrition", ",", "or", "C0015544#ent", "<e2>", "given", "nocturnal", "supplemental", "feeding", "by", "gastrostomy", "tube"], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0015544", "name": "C0015544#ent", "pos": [18, 19]}}
{"token": ["Increased", "energy", "expenditure", "poor", "dietary", "intake", "and", "fat", "malabsorption", "patients", "with", "C0010674#ent", "<e1>", "CF", ")", "frequently", "lead", "to", "C0015544#ent", "<e2>", "malnutrition", ",", "which", "are", "associated", "with", "pulmonary", "failure", "decreased", "survival", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0015544", "name": "C0015544#ent", "pos": [18, 19]}}
{"token": ["Steady-state", "kinetic", "studies", "recombinant", "human", "inducible", "C0132555#ent", "<e1>", "rH-iNOS", ")", "demonstrate", "that", "C0020923#ent", "<e2>", "and", "1-phenylimidazole", "are", "competitive", "and", "reversible", "inhibitors", "versus", "L-arginine", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020923", "name": "C0020923#ent", "pos": [12, 13]}}
{"token": ["C0132555#ent", "<e1>", "NOS", ")", "is", "inhibited", "by", "C0020923#ent", "<e2>", ",", "which", "binds", "to", "the", "heme", "in", "a", "low-spin", "complex", "absorbing", "at", "428", "nm", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020923", "name": "C0020923#ent", "pos": [7, 8]}}
{"token": ["We", "found", "that", "the", "expression", "of", "exogenous", "SHC", "C0086376#ent", "<e1>", "results", "in", "an", "increased", "basal", "MEK", "(", "C1334474#ent", "<e2>", "activity", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [17, 18]}}
{"token": ["This", "RBP4-specific", "aptamer", "was", "C2350558#ent", "<e1>", "on", "a", "gold", "chip", "used", "in", "a", "label-free", "C1419320#ent", "<e2>", "detection", "using", "SPR", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419320", "name": "C1419320#ent", "pos": [14, 15]}}
{"token": ["Patients", "presented", "with", "pneumonia", ",", "C0006267#ent", "<e1>", "with", "infection", ",", "previous", "C0041327#ent", "<e2>", "infection", "and", "diffuse", "panbronchiolitis"], "h": {"id": "C0006267", "name": "C0006267#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [11, 12]}}
{"token": ["In", "C0006267#ent", "<e1>", "patients", "having", "infections", "in", "association", "with", "C0041327#ent", "<e2>", "mixed", "infections", ",", "LVDM", "did", "not", "show", "any", "remarkable", "effects", ",", "excepting", "that", "fair", "cures", "were", "achieved", "in", "3", "patients", "."], "h": {"id": "C0006267", "name": "C0006267#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [9, 10]}}
{"token": ["The", "bactericidal", "action", "neutrophil", "polynuclear", "cells", "(", "NP", ")", "is", "significantly", "lower", "in", "the", "presence", "of", "diclofenac", "than", "in", "the", "presence", "of", "C0022635#ent", "<e1>", "in", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [27, 28]}}
{"token": ["In", "this", "study", "patient", "acceptability", "of", "five", "such", "agents", "(", "benoxaprofen", ",", "fenbufen", ",", "feprazone", ",", "flurbiprofen", ",", "C0022635#ent", "<e1>", ")", "is", "compared", "in", "groups", "of", "50", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [29, 30]}}
{"token": ["Similarly", ",", "C0600327#ent", "<e1>", "association", "with", "influenza", "B", "C0521839#ent", "<e2>", "been", "reported", "in", "12", "patients", ",", "but", "it", "has", "been", "reported", "to", "occur", "following", "influenza", "A", "only", "two", "patients", "to", "date", "."], "h": {"id": "C0600327", "name": "C0600327#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0521839", "name": "C0521839#ent", "pos": [8, 9]}}
{"token": ["The", "method", "uses", "biotinylated", "antiglobulin", "to", "streptavidin-coated", "microtiter", "plates", "to", "immobilize", "C0031671#ent", "<e1>", "C-gamma1", "antibody", "and", "subsequently", "capture", "C0250414#ent", "<e2>", "brain", "tissue", "lysates", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0250414", "name": "C0250414#ent", "pos": [18, 19]}}
{"token": ["These", "experiments", "showed", "that", "expression", "of", "tumor", "necrosis", "factor-alpha", "interferon-gamma", "was", "inhibited", "by", "C0003166#ent", "<e1>", ",", "whereas", "expression", "of", "interleukin-1alpha/beta", "and", "their", "C0019593#ent", "<e2>", "interleukin-1Ra", ",", "and", "interleukin-10", "was", "stimulated", "by", "C0003166#ent", "<e1>", "."], "h": {"id": "C0003166", "name": "C0003166#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "C1516119#ent", "<e1>", "induced", "phase", "II", "detoxification", "enzymes", ",", "UDP-glucuronosyltransferase", "1A1", "C1415328#ent", "<e2>", "mRNA", "expression", "."], "h": {"id": "C1516119", "name": "C1516119#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415328", "name": "C1415328#ent", "pos": [13, 14]}}
{"token": ["Fluconazole", "compliance", "was", "monitored", "electronically", "by", "using", "the", "Medication", "Event", "Systems", "with", "19", "women", "receiving", "C0016277#ent", "<e1>", "at", "50", "mg", "thrice", "weekly", "for", "prophylaxis", "of", "recurrent", "C0006845#ent", "<e2>"], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0006845", "name": "C0006845#ent", "pos": [26, 27]}}
{"token": ["These", "results", "suggest", "that", "C3541857#ent", "<e1>", "is", "a", "cluster", "gene", "coding", "a", "multifunctional", "protein", "both", "C1412104#ent", "<e2>", "enzyme", "activities", "on", "the", "same", "polypeptide", "chain"], "h": {"id": "C3541857", "name": "C3541857#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412104", "name": "C1412104#ent", "pos": [15, 16]}}
{"token": ["Data", "from", "genetic", "crosses", "soraphen", "A-resistant", "clones", "with", "an", "C3541857#ent", "<e1>", "mutant", "revealed", "that", "ACC1", ",", "coding", "for", "C1412104#ent", "<e2>", "E.C.", "6.4.1.2", ")", ",", "is", "tightly", "linked", "to", "soraphen", "A", "resistance", "."], "h": {"id": "C3541857", "name": "C3541857#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412104", "name": "C1412104#ent", "pos": [18, 19]}}
{"token": ["Our", "data", "suggest", "that", "C0069939#ent", "<e1>", "inhibits", "osteoclastogenesis", "from", "bone", "marrow", "stromal", "cells", "macrophage", "cells", "attenuated", "of", "RANKL-induced", "C3849574#ent", "<e2>", ",", "p38", "and", "NF-kappaB", "activation", "which", "in", "turn", "protect", "bone", "loss", "ovariectomy", "."], "h": {"id": "C0069939", "name": "C0069939#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [18, 19]}}
{"token": ["Further", "experiments", "demonstrated", "that", "C0020374#ent", "<e1>", "ACAT", "are", "regulated", "by", "different", "mechanisms", "than", "the", "C1416865#ent", "<e2>", "cholesterol", "side", "chain", "cleavage", "system"], "h": {"id": "C0020374", "name": "C0020374#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416865", "name": "C1416865#ent", "pos": [14, 15]}}
{"token": ["Administration", "of", "high", "doses", "angiotensin", "II", "C3273406#ent", "<e1>", "results", "in", "natriuretic", "and", "C0012798#ent", "<e2>", "responses", "that", "are", "mediated", "by", "increases", "in", "renal", "perfusion", "pressure", "RPP", ")", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [12, 13]}}
{"token": ["Intracerebroventricular", "injections", "of", "both", "hypertonic", "saline", "C3273406#ent", "<e1>", "dipsogenic", ",", "and", "C0012798#ent", "<e2>", "treatment", "followed", "by", "a", "short", "period", "of", "sodium", "deprivation", "induces", "salt", "intake"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [11, 12]}}
{"token": ["C3889256#ent", "<e1>", "was", "effectively", "solubilized", "from", "bovine", "P2", "membranes", "by", "C0136864#ent", "<e2>", "PI-PLC", ")", ",", "indicating", "that", "C3889256#ent", "<e1>", "is", "a", "glycosylphosphatidylinositol", "(GPI)-anchored", "protein"], "h": {"id": "C0136864", "name": "C0136864#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889256", "name": "C3889256#ent", "pos": [0, 1]}}
{"token": ["To", "examine", "single-nucleotide", "polymorphisms", "SNPs", ")", "of", "the", "C1335554#ent", "<e1>", "C1335057#ent", "<e2>", ")", "and", "to", "study", "the", "relationship", "between", "C1335057#ent", "<e2>", "and", "the", "HLA", "region", "in", "patients", "with", "idiopathic", "inflammatory", "myopathies", "IIMs", ")", "."], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1335057", "name": "C1335057#ent", "pos": [10, 11]}}
{"token": ["The", "C1335554#ent", "<e1>", "nonreceptor", "22", "gene", "(", "C1335057#ent", "<e2>", ")", "maps", "to", "human", "chromosome", "1p13.3-p13.1", "encodes", "an", "important", "negative", "regulator", "of", "T-cell", "activation", "lymphoid-specific", "phosphatase", "Lyp", ")", "."], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1335057", "name": "C1335057#ent", "pos": [7, 8]}}
{"token": ["We", "describe", "the", "various", "hepatic", "complications", ",", "including", "hepatitis", ",", "cirrhosis", ",", "and", "C0085605#ent", "<e1>", "in", "addition", "to", "the", "hematological", "complications", "DIC", "and", "C0034155#ent", "<e2>", "secondary", "to", "ecstasy", "abuse"], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0034155", "name": "C0034155#ent", "pos": [23, 24]}}
{"token": ["Full-length", "recombinant", "vWF", "produced", "from", "transfected", "Chinese", "hamster", "ovary", "cells", "cleared", "at", "a", "similar", "rate", "to", "C1416870#ent", "<e1>", "and", "recombinant", "C1336938#ent", "<e2>", "devoid", "of", "O-linked", "carbohydrates", "was", "cleared", "significantly", "faster", "."], "h": {"id": "C1416870", "name": "C1416870#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [20, 21]}}
{"token": ["Similar", "measurements", "in", "100", "mM", "K", "solution", "with", "the", "C1416587#ent", "<e1>", "off", "by", "a", "positive", "prepulse", ",", "gave", "C1423073#ent", "<e2>", "=", "20", "mumho/cm", "and", "Cm", "'", "=", "2.0", "muF/cm2", "."], "h": {"id": "C1416587", "name": "C1416587#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1423073", "name": "C1423073#ent", "pos": [18, 19]}}
{"token": ["C1332721#ent", "<e1>", "phosphorylation", "of", "C1423710#ent", "<e2>", "appears", "to", "be", "one", "of", "multiple", "mechanisms", "by", "which", "C1332721#ent", "<e1>", "prevents", "DNA", "rereplication", "a", "single", "cell", "cycle"], "h": {"id": "C1332721", "name": "C1332721#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423710", "name": "C1423710#ent", "pos": [4, 5]}}
{"token": ["Thus", ",", "C1332721#ent", "<e1>", "phosphorylation", "of", "C1423710#ent", "<e2>", "may", "be", "redundant", "with", "regulation", "of", "Cdc18", "for", "preventing", "reinitiation", "of", "DNA", "synthesis"], "h": {"id": "C1332721", "name": "C1332721#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423710", "name": "C1423710#ent", "pos": [6, 7]}}
{"token": ["HT29", "and", "SW620", "cells", "yielded", "similar", "fragment", "size", "distributions", "upon", "treatment", "with", "either", "FdUrd", "or", "C0054911#ent", "<e1>", "[", "a", "folate", "analog", "of", "C1366824#ent", "<e2>", "TS", ")", "]", "."], "h": {"id": "C0054911", "name": "C0054911#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1366824", "name": "C1366824#ent", "pos": [22, 23]}}
{"token": ["We", "have", "induced", "drug", "resistance", "methotrexate", ",", "an", "inhibitor", "of", "dihydrofolate", "reductase", "and", "C0054911#ent", "<e1>", ",", "an", "inhibitor", "of", "C1366824#ent", "<e2>", "a", "strain", "of", "Leishmania", "tarentolae"], "h": {"id": "C0054911", "name": "C0054911#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366824", "name": "C1366824#ent", "pos": [19, 20]}}
{"token": ["C0054911#ent", "<e1>", "is", "a", "quinazoline", "antifolate", "cytotoxic", "activity", "mediated", "by", "inhibition", "of", "thymidylate", "synthase", "C1366824#ent", "<e2>", ")", "."], "h": {"id": "C0054911", "name": "C0054911#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366824", "name": "C1366824#ent", "pos": [14, 15]}}
{"token": ["A", "case", "of", "a", "child", "with", "subacute", "neurologic", "features", "and", "imaging", "findings", "consistent", "with", "C0393483#ent", "<e1>", "was", "discovered", "to", "be", "related", "to", "a", "C0007684#ent", "<e2>", "by", "Epstein-Barr", "virus", "presented", "."], "h": {"id": "C0393483", "name": "C0393483#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007684", "name": "C0007684#ent", "pos": [23, 24]}}
{"token": ["Fc", "receptor-mediated", "mononuclear", "phagocyte", "system", "(", "MPS", ")", "clearance", "is", "impaired", "in", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e1>", ")", "and", "may", "contribute", "to", "the", "pathogenesis", "of", "the", "C0020951#ent", "<e2>"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [26, 27]}}
{"token": ["Western", "blot", "analysis", "a", "significant", "increase", "in", "the", "expression", "of", "calcium-dependent", "C0536678#ent", "<e1>", "and", "a", "50-kDa", "protein", "immunoreactive", "to", "calcium-independent", "C1418624#ent", "<e2>", "antibody", "in", "gd20", "compared", "to", "gd10", "rat", "uterine", "tissue"], "h": {"id": "C0536678", "name": "C0536678#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418624", "name": "C1418624#ent", "pos": [20, 21]}}
{"token": ["Because", "the", "vascular", "disease", "associated", "with", "hypertension", "evolves", "over", "the", "years", ",", "we", "investigated", "platelet", "activity", "parameters", "in", "a", "population", "of", "C0020538#ent", "<e1>", "patients", "with", "no", "other", "risk", "factors", "C0007222#ent", "<e2>"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [21, 22]}, "relation": "has_nichd_parent", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [29, 30]}}
{"token": ["Myeloperoxidase", "(", "MPO", ")", ",", "C0059407#ent", "<e1>", "EPX", ")", "and", "C1416903#ent", "<e2>", "(", "LPO", ")", "are", "mammalian", "peroxidase", "enzymes", "possessing", "similar", "structures", "and", "functions", "."], "h": {"id": "C0059407", "name": "C0059407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416903", "name": "C1416903#ent", "pos": [10, 11]}}
{"token": ["Arachidonic", "acid", "iodination", "in", "the", "presence", "of", "hydrogen", "peroxide", "iodide", ",", "and", "either", "C0059407#ent", "<e1>", "myeloperoxidase", "or", "C1416903#ent", "<e2>", "."], "h": {"id": "C0059407", "name": "C0059407#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416903", "name": "C1416903#ent", "pos": [17, 18]}}
{"token": ["We", "have", "explored", "the", "contribution", "of", "the", "interaction", "of", "HIV-1", "C0079423#ent", "<e1>", "with", "HHR23A", ",", "a", "cellular", "protein", "in", "C1333237#ent", "<e2>", "to", "the", "known", "phenotypes", "of", "C0079423#ent", "<e1>", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0079423", "name": "C0079423#ent", "pos": [10, 11]}}
{"token": ["C0812278#ent", "<e1>", "Celsr3", ")", "and", "the", "receptor", "Frizzled3", "C1333589#ent", "<e2>", ")", "are", "crucial", "for", "the", "development", "of", "axonal", "tracts", "in", "the", "mouse", "CNS", "."], "h": {"id": "C0812278", "name": "C0812278#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333589", "name": "C1333589#ent", "pos": [8, 9]}}
{"token": ["The", "yearly", "exposure", "of", "least", "50", "million", "pregnancies", "to", "C0024530#ent", "<e1>", "infection", "makes", "it", "the", "commonest", "and", "most", "recurrent", "C0030499#ent", "<e2>", "affecting", "the", "placenta", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [19, 20]}}
{"token": ["Tissues", "quantities", "of", "5", "to", "25", "micrograms", "dry", "weight", "incubated", "under", "C0727050#ent", "<e1>", "reaction", "volumes", "5", "microliters", "and", "analyzed", "for", "cyclic", "adenosine", "3':5'-monophosphate", "phosphodiesterase", "C1849508#ent", "<e2>", ")", "."], "h": {"id": "C0727050", "name": "C0727050#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1849508", "name": "C1849508#ent", "pos": [24, 25]}}
{"token": ["In", "eleven", "pregnant", "patients", "with", "ulcerative", "colitis", "C0156147#ent", "<e1>", "were", "treated", "with", "sulphasalazine", "(", "C2239905#ent", "<e2>", ")", "the", "serum", "concentrations", "of", "C2239905#ent", "<e2>", "and", "sulphapyridine", "(", "SP", ")", "were", "measured", "at", "delivery", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2239905", "name": "C2239905#ent", "pos": [14, 15]}}
{"token": ["In", "123", "out-patients", "with", "C0156147#ent", "<e1>", "reliability", "in", "taking", "the", "prescribed", "therapy", "with", "salazosulfapyridine", "(", "C2239905#ent", "<e2>", ")", "was", "studied", "over", "an", "one", "year", "period", "in", "a", "special", "out-patient", "clinic", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2239905", "name": "C2239905#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "C0114771#ent", "<e1>", "is", "more", "effective", "than", "C0086303#ent", "<e2>", "in", "the", "conversion", "of", "atrial", "flutter", "sinus", "rhythm", ",", "despite", "the", "fact", "that", "C0086303#ent", "<e2>", "produced", "a", "more", "prolonged", "flutter", "cycle", "length", "."], "h": {"id": "C0114771", "name": "C0114771#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086303", "name": "C0086303#ent", "pos": [9, 10]}}
{"token": ["A", "similar", "phenotype", "to", "that", "of", "C1336626#ent", "<e1>", "transfected", "cells", "was", "observed", "when", "endogenous", "C1706508#ent", "<e2>", "levels", "were", "down", "regulated", "by", "anti-sense", "transfection", "of", "bEND.3", "cells", "."], "h": {"id": "C1336626", "name": "C1336626#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706508", "name": "C1706508#ent", "pos": [14, 15]}}
{"token": ["It", "is", "shown", "that", "some", "new", "C0003299#ent", "<e1>", "such", "as", "C0772200#ent", "<e2>", ",", "have", "spike-wave", "discharge-increasing", "properties", ",", "while", "other", "drugs", "are", "worth", "studying", "in", "clinical", "trials", "antiabsence", "treatment", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [6, 7]}, "relation": "therapeutic_class_of", "t": {"id": "C0772200", "name": "C0772200#ent", "pos": [10, 11]}}
{"token": ["Two", "recently", "developed", "C0003299#ent", "<e1>", "AEDs", ")", ",", "vigabatrin", "(", "VGB", ")", "and", "C0772200#ent", "<e2>", "(", "TGB", ")", ",", "are", "examples", "of", "such", "agents", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0772200", "name": "C0772200#ent", "pos": [13, 14]}}
{"token": ["Differences", "were", "observed", "between", "BBM", "and", "C1861821#ent", "<e1>", "in", "their", "lipid", "composition", "sugar", "content", ",", "alkaline", "phosphatase", "C1427121#ent", "<e2>", ")", "activity", "and", "cholesterol/phospholipid", "ratio", "."], "h": {"id": "C1861821", "name": "C1861821#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1427121", "name": "C1427121#ent", "pos": [17, 18]}}
{"token": ["The", "present", "results", "indicate", "that", "age", "correlates", "with", "the", "pressor", "but", "not", "the", "chronotropic", "effects", "C0033798#ent", "<e1>", "in", "pediatric", "patients", "anesthetized", "with", "1", "C4049728#ent", "<e2>", "halothane", "and", "nitrous", "oxide"], "h": {"id": "C0033798", "name": "C0033798#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4049728", "name": "C4049728#ent", "pos": [23, 24]}}
{"token": ["However", ",", "in", "some", "C0013080#ent", "<e1>", "patients", "with", "apparent", "transient", "C0023501#ent", "<e2>", "leukemia", "relapse", "following", "periods", "of", "spontaneous", "remission", "been", "reported", "."], "h": {"id": "C0013080", "name": "C0013080#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0023501", "name": "C0023501#ent", "pos": [10, 11]}}
{"token": ["Twenty-six", "C0341703#ent", "<e1>", "were", "identified", ",", "one", "of", "which", "corresponds", "to", "the", "C3538708#ent", "<e2>", "encoding", "a", "cold-shock", "protein"], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3538708", "name": "C3538708#ent", "pos": [12, 13]}}
{"token": ["C0751185#ent", "<e1>", "defined", "as", "C0018681#ent", "<e2>", "on", "by", "coughing", "or", "other", "Valsalva", "maneuvers", "but", "not", "by", "prolonged", "physical", "exercise", "in", "the", "absence", "of", "any", "intracranial", "disorder"], "h": {"id": "C0751185", "name": "C0751185#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [4, 5]}}
{"token": ["C0751185#ent", "<e1>", "benign", "exertional", "headache", "and", "C0018681#ent", "<e2>", "associated", "with", "sexual", "activity", "occurred", "in", "1", "%", "."], "h": {"id": "C0751185", "name": "C0751185#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [6, 7]}}
{"token": ["Because", "synaptic", "transmission", "subthalamic", "output", "is", "glutamatergic", "and", "mediated", ",", "in", "part", ",", "by", "the", "alpha-amino-3-hydroxy-5-methyl-4-isoxazole", "propionate", "AMPA", ")", "subtype", "of", "C1415287#ent", "<e1>", "AMPA", "receptor", "antagonists", "may", "possess", "C0003405#ent", "<e2>"], "h": {"id": "C1415287", "name": "C1415287#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [28, 29]}}
{"token": ["Biochemically", "matriptase-2", "has", "substrate", "specificity", "similar", "to", "the", "structurally", "related", "C1366520#ent", "<e1>", "also", "known", "as", "C0769218#ent", "<e2>", ")", "."], "h": {"id": "C1366520", "name": "C1366520#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0769218", "name": "C0769218#ent", "pos": [15, 16]}}
{"token": ["The", "mediators", "histamine", ",", "slow", "reacting", "substance", "of", "anaphylaxis", "and", "C0014457#ent", "<e1>", "chemotactic", "factor", "smooth", "muscle", "contraction", "increased", "capillary", "permeability", "C0014457#ent", "<e1>", "C1412696#ent", "<e1>", "and", "increased", "glandular", "secretions"], "h": {"id": "C0014457", "name": "C0014457#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412696", "name": "C1412696#ent", "pos": [22, 23]}}
{"token": ["We", "conclude", "that", "C0060470#ent", "<e1>", "improves", "submaximal", "exercise", "performance", "in", "patients", "with", "C0264716#ent", "<e2>", "probably", "by", "enhancing", "skeletal", "muscle", "blood", "flow"], "h": {"id": "C0060470", "name": "C0060470#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0264716", "name": "C0264716#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "the", "incorporation", "of", "a", "matrix", "attachment", "region", "C1366332#ent", "<e1>", "increased", "transduction", "of", "C0669372#ent", "<e2>", "in", "vivo"], "h": {"id": "C1366332", "name": "C1366332#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [14, 15]}}
{"token": ["Pemetrexed", "and", "C0594375#ent", "<e1>", "have", "demonstrated", "antitumor", "activity", "single", "agents", "lung", ",", "C0030304#ent", "<e2>", ",", "breast", ",", "and", "colorectal", "cancer", "CRC", ")", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030304", "name": "C0030304#ent", "pos": [12, 13]}}
{"token": ["Two", "connective", "tissue", "diseases", "accompanied", "by", "C1540912#ent", "<e1>", "are", "Churg", "and", "C0042384#ent", "<e2>", "eosinophilic", "fascitis"], "h": {"id": "C1540912", "name": "C1540912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [11, 12]}}
{"token": ["Specifically", ",", "the", "molecular", "interactions", "C0919445#ent", "<e1>", "with", "the", "cell", "surface-associated", "pro-urokinase-type", "plasminogen", "activator", "pro-uPA", ")", "and", "intracellular", "C1334032#ent", "<e2>", "HDAC1", ")", "are", "highlighted", "."], "h": {"id": "C0919445", "name": "C0919445#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [18, 19]}}
{"token": ["Previously", ",", "we", "reported", "overlap", "in", "the", "repertoires", "of", "C0030956#ent", "<e1>", "endogenously", "bound", "by", "a", "group", "of", "C1415561#ent", "<e2>", "to", "HLA-B7", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415561", "name": "C1415561#ent", "pos": [17, 18]}}
{"token": ["Together", "with", "B*3909", ",", "B*3905", "is", "the", "second", "HLA-B39", "subtype", "polymorphism", "results", "in", "a", "shift", "of", "C0030956#ent", "<e1>", "specificity", "towards", "that", "of", "C1415561#ent", "<e2>", "absent", "from", "these", "populations", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415561", "name": "C1415561#ent", "pos": [22, 23]}}
{"token": ["After", "a", "single", "administration", "of", "hMG", ",", "C1334130#ent", "<e1>", "mRNA", "in", "the", "human", "testis", "significantly", "increased", ",", "whereas", "C1334132#ent", "<e2>", "mRNA", "remained", "unchanged", "."], "h": {"id": "C1334130", "name": "C1334130#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334132", "name": "C1334132#ent", "pos": [18, 19]}}
{"token": ["Our", "results", "confirm", "that", "C0061617#ent", "<e1>", "is", "synthesized", "as", "C1305923#ent", "<e2>", "undergo", "post-translational", "processing", "form", "the", "nonrandom", "polypeptide", "pairs", "via", "disulfide", "bonds"], "h": {"id": "C0061617", "name": "C0061617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [9, 10]}}
{"token": ["The", "four", "antiherpes", "compounds", "acyclovir", ",", "adenine", "arabinoside", "bromovinyldeoxyuridine", ",", "and", "C0070895#ent", "<e1>", "an", "additive", "to", "synergistic", "effect", "human", "C0751598#ent", "<e2>", "inhibiting", "focus", "formation", "by", "three", "different", "strains", "of", "varicella-zoster", "virus", "human", "embryonic", "fibroblasts", "."], "h": {"id": "C0070895", "name": "C0070895#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0751598", "name": "C0751598#ent", "pos": [19, 20]}}
{"token": ["In", "all", "C1442905#ent", "<e1>", "patients", "investigated", "a", "C0034072#ent", "<e2>", "involvement", "occurred", "based", "on", "non-invasive", "methods"], "h": {"id": "C1442905", "name": "C1442905#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [7, 8]}}
{"token": ["In", "contrast", ",", "the", "hepatocyte-like", "cells", "colonizing", "the", "mesentery", "showed", "the", "phenotype", "of", "mature", "hepatocytes", ",", "including", "an", "abundant", "C0017919#ent", "<e1>", "a", "lack", "of", "alpha-fetoprotein", "and", "C1413043#ent", "<e2>", "expressions", "."], "h": {"id": "C0017919", "name": "C0017919#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [26, 27]}}
{"token": ["Surprisingly", ",", "PD-1", "C1416746#ent", "<e1>", "mice", "retained", "normal", "levels", "of", "C1416467#ent", "<e2>", "expression", ",", "but", "Tregs", "from", "these", "mice", "lacked", "functional", "suppression", "."], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416467", "name": "C1416467#ent", "pos": [10, 11]}}
{"token": ["However", ",", "E2", "pre-treatment", "of", "PD-1", "C1416746#ent", "<e1>", "mice", "partially", "restored", "functional", "Treg", "suppression", "without", "enhancing", "C1416467#ent", "<e2>", "expression", "."], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416467", "name": "C1416467#ent", "pos": [16, 17]}}
{"token": ["Protease-activated", "receptor-2", "a", "G", "protein-coupled", "receptor", "activated", "by", "serine", "proteases", "as", "trypsin", ",", "tryptase", "and", "coagulation", "factors", "C0268345#ent", "<e1>", "and", "Xa", ",", "modulates", "C0030304#ent", "<e2>", "and", "salivary", "exocrine", "secretion"], "h": {"id": "C0268345", "name": "C0268345#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030304", "name": "C0030304#ent", "pos": [23, 24]}}
{"token": ["As", "C1705952#ent", "<e1>", "is", "supposed", "to", "be", "C0221777#ent", "<e2>", ",", "it", "will", "be", "a", "major", "challenge", "to", "design", "surrogate", "end", "points", "to", "find", "the", "optimal", "dose", "in", "the", "clinic", "."], "h": {"id": "C1705952", "name": "C1705952#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0221777", "name": "C0221777#ent", "pos": [7, 8]}}
{"token": ["Using", "a", "C0035542#ent", "<e1>", "increased", "mRNA", "levels", "of", "C0087140#ent", "<e2>", "and", "jun", "family", "members", "seen", "in", "response", "to", "DQ12", "quartz", "and", "CMD", "with", "high", "quartz", "content", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [8, 9]}}
{"token": ["The", "majority", "of", "the", "Fos", "protein", "complex", "released", "from", "isolated", "nuclei", "incubated", "in", "the", "presence", "of", "deoxyribonuclease", "I", "micrococcal", "nuclease", "not", "with", "C0035542#ent", "<e1>", "suggesting", "that", "C0087140#ent", "<e2>", "is", "associated", "with", "chromatin", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [26, 27]}}
{"token": ["Diabetes", "and", "C0268790#ent", "<e1>", "coexist", "and", "ED", "may", "be", "a", "marker", "for", "silent", "C1306889#ent", "<e2>", "for", "which", "the", "patient", "should", "be", "screened", "."], "h": {"id": "C0268790", "name": "C0268790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1306889", "name": "C1306889#ent", "pos": [13, 14]}}
{"token": ["The", "pharmacokinetics", "of", "C0015837#ent", "<e1>", "were", "investigated", "in", "several", "studies", "in", "healthy", "volunteers", "in", "C0003873#ent", "<e2>", "patients", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["The", "data", "indicate", "that", "C0015837#ent", "<e1>", "is", "an", "additional", "valuable", "agent", "for", "C0003873#ent", "<e2>"], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}}
{"token": ["The", "purified", "protein", "ATP", "binding", "and", "C0001473#ent", "<e1>", "and", "ATP-", "or", "C2975630#ent", "<e2>", "activity", "requiring", "either", "Mg2", "+", "or", "Mn2", "+", "as", "a", "cofactor", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2975630", "name": "C2975630#ent", "pos": [11, 12]}}
{"token": ["The", "purified", "recombinant", "NS1", "protein", "C0001473#ent", "<e1>", "and", "ATP-", "or", "C2975630#ent", "<e2>", "activity", "requiring", "either", "Mg(2", "+", ")", "or", "Mn(2", "+", ")", "as", "a", "cofactor", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2975630", "name": "C2975630#ent", "pos": [10, 11]}}
{"token": ["MUC1", "apomucin", "is", "a", "specific", "target", "C1710492#ent", "<e1>", "by", "cytotoxic", "T", "cells", "a", "major", "histocompatibility", "complex", "C0024518#ent", "<e2>", ")", "unrestricted", "fashion", "in", "patients", "with", "pancreatic", "and", "breast", "cancer"], "h": {"id": "C1710492", "name": "C1710492#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [16, 17]}}
{"token": ["In", "this", "work", ",", "using", "in", "vivo", "bioluminescence", "resonance", "energy", "transfer", "BRET", ")", "assays", "and", "in", "vitro", "co-immunoprecipitation", ",", "we", "show", "that", "C1704803#ent", "<e1>", "interacts", "with", "the", "active", "form", "C1419385#ent", "<e2>", "G14V", ")", "proteins", "."], "h": {"id": "C1704803", "name": "C1704803#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [29, 30]}}
{"token": ["In", "generating", "inducible", "cell", "lines", "C2987364#ent", "<e1>", "isoforms", "of", "C0694898#ent", "<e2>", "and", "WT1", "mutants", "we", "observed", "dramatic", "differences", "in", "the", "subnuclear", "localization", "of", "the", "induced", "proteins", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0694898", "name": "C0694898#ent", "pos": [9, 10]}}
{"token": ["Hyperthyroid", "neonates", "may", "be", "treated", "with", "antithyroid", "drugs", "beta-adrenergic", "receptor", "blocking", "agents", "C0885449#ent", "<e1>", ",", "or", "iodinated", "contrast", "agents", "and", "at", "times", ",", "with", "C3540778#ent", "<e2>", "and", "digoxin", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [24, 25]}}
{"token": ["E2F1", "dissociates", "from", "Rb", "in", "cells", "depleted", "of", "C1418822#ent", "<e1>", "and", "the", "resulting", "apoptosis", "is", "dependent", "on", "C1705065#ent", "<e2>", "."], "h": {"id": "C1418822", "name": "C1418822#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [17, 18]}}
{"token": ["C4083833#ent", "<e1>", "in", "the", "direction", "malate", "oxalacetate", "is", "much", "less", "sensitive", "to", "C1414518#ent", "<e2>", ",", "with", "Ki", "values", "of", "50", "muM", "at", "pH", "10", "and", "greater", "than", "50", "muM", "at", "pH", "7.4", "."], "h": {"id": "C4083833", "name": "C4083833#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414518", "name": "C1414518#ent", "pos": [12, 13]}}
{"token": ["Studies", "on", "the", "metabolism", "of", "C0005080#ent", "<e1>", "revealed", "that", "the", "C0919425#ent", "<e2>", "AHH", ")", "is", "present", "in", "cultured", "hair", "follicle", "cells"], "h": {"id": "C0005080", "name": "C0005080#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [10, 11]}}
{"token": ["Altered", "metabolism", "of", "C0005080#ent", "<e1>", "due", "to", "the", "polymorphism", "in", "the", "C0919425#ent", "<e2>", "be", "an", "etiologic", "factor", "the", "increased", "incidence", "of", "AA", "in", "these", "patients", "."], "h": {"id": "C0005080", "name": "C0005080#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [11, 12]}}
{"token": ["Expression", "of", "C1417679#ent", "<e1>", "encoding", "antioxidant", "proteins", "induced", "in", "the", "wild", "type", "not", "in", "C1421305#ent", "<e2>", "mutants", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421305", "name": "C1421305#ent", "pos": [14, 15]}}
{"token": ["A", "25-year-old", "man", "who", "had", "recurrent", "sore", "throats", "with", "sharp", "C0008031#ent", "<e1>", "hours", "after", "starting", "penicillin", "for", "C0040425#ent", "<e2>", "."], "h": {"id": "C0008031", "name": "C0008031#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040425", "name": "C0040425#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "the", "three", "DMARDs", "sulphasalazine", ",", "sodium", "aurothiomalate", "C0030817#ent", "<e1>", ",", "smoking", "and", "the", "intake", "of", "various", "C1176140#ent", "<e2>", "substrates", "had", "no", "consistent", "detectable", "effect", "on", "the", "6", "beta-OHC/Creat", "ratio", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [19, 20]}}
{"token": ["We", "performed", "a", "biochemical", "screen", "discover", "potential", "regulators", "of", "C1826449#ent", "<e1>", "and", "identified", "C1333352#ent", "<e2>", ",", "a", "protein", "involved", "in", "cell", "polarity", "receptor", "localization", "and", "regulation", "of", "the", "mitogen-activated", "protein", "kinase", "pathway", "as", "a", "novel", "Nod2-interacting", "protein", "."], "h": {"id": "C1826449", "name": "C1826449#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333352", "name": "C1333352#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "knock-down", "of", "beta-PIX", "or", "Rac1", "abrogated", "membrane", "recruitment", "C1826449#ent", "<e1>", ",", "and", "interaction", "of", "C1826449#ent", "<e1>", "with", "its", "negative", "regulator", "C1333352#ent", "<e1>", "."], "h": {"id": "C1826449", "name": "C1826449#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333352", "name": "C1333352#ent", "pos": [22, 23]}}
{"token": ["Sequence", "analysis", "C0242965#ent", "<e1>", "has", "revealed", "that", "C0534137#ent", "<e2>", "is", "a", "gene", "super-family", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [7, 8]}}
{"token": ["These", "effects", "of", "C0031923#ent", "<e1>", "on", "behavioral", "states", "breathing", "movements", "blocked", "by", "atropine", "sulfate", "not", "by", "C0066332#ent", "<e2>", "."], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0066332", "name": "C0066332#ent", "pos": [16, 17]}}
{"token": ["Three", "of", "them", "needed", "additional", "C0003299#ent", "<e1>", "clonazepam", "in", "two", "patients", "and", "C0015043#ent", "<e2>", "in", "one", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [5, 6]}, "relation": "therapeutic_class_of", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [12, 13]}}
{"token": ["Conventional", "C0003299#ent", "<e1>", "AEDs", ")", "include", "phenytoin", ",", "carbamazepine", ",", "valproic", "acid", "C0015043#ent", "<e2>", ",", "barbiturates", ",", "and", "benzodiazepines", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [12, 13]}}
{"token": ["The", "well-known", "C0003299#ent", "<e1>", ",", "trimethadione", "(", "TMO", ")", ",", "C0015043#ent", "<e2>", "(", "ESM", ")", ",", "and", "phenytoin", "(", "PHT", ")", ",", "were", "included", "as", "reference", "drugs"], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [10, 11]}}
{"token": ["In", "summary", ",", "C3539616#ent", "<e1>", "protects", "PC", "and", "C1425400#ent", "<e2>", "apoptosis", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425400", "name": "C1425400#ent", "pos": [8, 9]}}
{"token": ["Sodium", "butyrate", "a", "C0019643#ent", "<e1>", "inhibitor", "causing", "growth", "arrest", "differentiation", ",", "increases", "C0123707#ent", "<e2>", "expression", "."], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0123707", "name": "C0123707#ent", "pos": [12, 13]}}
{"token": ["A", "14-year-old", "boy", "with", "a", "history", "of", "2", "years", "of", "C0452143#ent", "<e1>", "rectal", "and", "urinary", "incontinence", "two", "spontaneous", "C0038525#ent", "<e2>", "encountered", "in", "August", "1993", "."], "h": {"id": "C0452143", "name": "C0452143#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [18, 19]}}
{"token": ["C0017922#ent", "<e1>", "GSD-1a", ")", "is", "a", "metabolic", "disorder", "by", "C0271708#ent", "<e2>", "hepatic", "steatosis", "and", "hyperlipidemia", "."], "h": {"id": "C0017922", "name": "C0017922#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271708", "name": "C0271708#ent", "pos": [9, 10]}}
{"token": ["To", "evaluate", "the", "effect", "of", "serum", "amyloid", "A", "SAA", ")", "1", "and", "SAA2", "gene", "polymorphisms", "on", "SAA", "levels", "and", "C0268382#ent", "<e1>", "Turkish", "patients", "with", "C0031069#ent", "<e2>", "FMF", ")", "."], "h": {"id": "C0268382", "name": "C0268382#ent", "pos": [19, 20]}, "relation": "manifestation_of", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [24, 25]}}
{"token": ["The", "repolarization", "has", "been", "blunted", "by", "the", "C3658209#ent", "<e1>", "mepacrine", ",", "but", "not", "by", "the", "C3536910#ent", "<e2>", "indomethacin", "."], "h": {"id": "C3658209", "name": "C3658209#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536910", "name": "C3536910#ent", "pos": [15, 16]}}
{"token": ["In", "particular", ",", "we", "investigate", "the", "mechanisms", "of", "loop", "diuretic", "ototoxicity", "C0029896#ent", "<e1>", "with", "hearing", "loss", "which", "C0071766#ent", "<e2>", "Cl(-", ")", "transport", "are", "compromised", ",", "such", "as", "Jervell", "and", "Lange-Nielsen", "syndrome", "Bartter", "syndrome", "type", "IV", "respectively", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0071766", "name": "C0071766#ent", "pos": [17, 18]}}
{"token": ["We", "considered", "SBT/CPZ", "combined", "with", "an", "C3536835#ent", "<e1>", "is", "a", "useful", "chemotherapy", "for", "C0035243#ent", "<e2>", "patients", "with", "underlying", "diseases", "and", "acute", "exacerbation", "chronic", "respiratory", "tract", "infections"], "h": {"id": "C3536835", "name": "C3536835#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [13, 14]}}
{"token": ["Patients", "had", "normal", "birthweight", "term", ",", "no", "hypothermia", ",", "and", "survived", "beyond", "the", "usual", "C0022716#ent", "<e1>", "age", "group", "with", "C0042075#ent", "<e2>", "hypotonia", "and", "choreoathetosis", "."], "h": {"id": "C0022716", "name": "C0022716#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [19, 20]}}
{"token": ["The", "observations", "indicate", "that", "PCR-based", "methods", "allow", "quantitation", "of", "changes", "in", "glomerular", "C1515406#ent", "<e1>", "expression", "in", "the", "course", "of", "C0017658#ent", "<e2>", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [19, 20]}}
{"token": ["Overexpression", "of", "C1515406#ent", "<e1>", "TGF-beta", ")", "underlies", "the", "accumulation", "of", "pathological", "matrix", "C0017658#ent", "<e2>"], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [12, 13]}}
{"token": ["Tumor", "cells", "positive", "for", "cytokeratins", ",", "mitochondrial-antigen", "(", "C1417154#ent", "<e1>", ")", ",", "epithelial", "membrane", "antigen", "EMA", ")", ",", "and", "C1419140#ent", "<e2>", ";", "five", "of", "seven", "tumors", "were", "focally", "positive", "CD117", "."], "h": {"id": "C1417154", "name": "C1417154#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419140", "name": "C1419140#ent", "pos": [19, 20]}}
{"token": ["C1420239#ent", "<e1>", "co-localized", "with", "RACK1", "as", "well", "as", "beta1", "integrin", "C1419150#ent", "<e2>", "and", "vinculin", ",", "suggesting", "that", "C1420239#ent", "<e1>", "associates", "with", "focal", "adhesions"], "h": {"id": "C1419150", "name": "C1419150#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420239", "name": "C1420239#ent", "pos": [0, 1]}}
{"token": ["Furthermore", ",", "all", "resistant", "cell", "lines", "C1333205#ent", "<e1>", "deficient", "and", "harbored", "different", "mutations", "in", "the", "C0011486#ent", "<e2>"], "h": {"id": "C1333205", "name": "C1333205#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0011486", "name": "C0011486#ent", "pos": [15, 16]}}
{"token": ["Caspase", "8", "inhibition", "protects", "both", "CPT-11", "pretreated", "C2987364#ent", "<e1>", "and", "Bax-/-", "HCT116", "cells", "TRAIL-induced", "apoptosis", ",", "whereas", "C0910167#ent", "<e2>", "inhibition", "only", "rescued", "the", "C2987364#ent", "<e1>", "HCT116", "cells", "death", "induced", "by", "TRAIL", "."], "h": {"id": "C0910167", "name": "C0910167#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "mast", "cells", "Apaf-1", "or", "C0910167#ent", "<e1>", "had", "no", "survival", "over", "C2987364#ent", "<e2>", "counterparts", "in", "vivo"], "h": {"id": "C0910167", "name": "C0910167#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}}
{"token": ["In", "fasted", "adrenalectomized", "rats", ",", "corticosterone", "replacement", "increased", "GHRH-R", "mRNA", "levels", "and", "intensified", "the", "C3272715#ent", "<e1>", "decrease", "in", "GHRH", ",", "but", "did", "not", "alter", "C1417815#ent", "<e2>", "or", "GHS-R", "response", "."], "h": {"id": "C3272715", "name": "C3272715#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [24, 25]}}
{"token": ["The", "saturation", "of", "the", "fat", "contained", "in", "the", "diet", "has", "been", "observed", "to", "affect", "the", "acylcoenzyme", "A:", "C0008380#ent", "<e1>", "ACAT", ")", "activity", "of", "rat", "C0023899#ent", "<e2>", "microsomes", "."], "h": {"id": "C0008380", "name": "C0008380#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [24, 25]}}
{"token": ["E2", "induced", "the", "phosphorylation", "of", "Akt", ",", "and", "pretreatment", "with", "a", "C0044602#ent", "<e1>", "PI3", "K", ")", "inhibitor", ",", "LY294002", ",", "attenuated", "the", "C2987147#ent", "<e2>", "increases", "of", "the", "telomerase", "activity", "hTERT", "promoter", "activity"], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987147", "name": "C2987147#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "pretreatment", "with", "wortmannin", "(", "C0044602#ent", "<e1>", "or", "U73122", "(", "phospholipase", "C", "attenuated", "the", "C2987147#ent", "<e2>", "reduction", "in", "nonclassical", "transcription"], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987147", "name": "C2987147#ent", "pos": [15, 16]}}
{"token": ["In", "addition", "to", "the", "previously", "reported", "homology", "with", "C1706105#ent", "<e1>", "the", "sucrase", "and", "C0028941#ent", "<e2>", "appear", "to", "be", "homologous", "to", "a", "yeast", "glucoamylase"], "h": {"id": "C1706105", "name": "C1706105#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028941", "name": "C0028941#ent", "pos": [13, 14]}}
{"token": ["It", "is", "felt", "that", "in", "patients", "with", "C0234133#ent", "<e1>", "diazepam", "should", "be", "considered", "as", "the", "possible", "C1254351#ent", "<e2>", "."], "h": {"id": "C0234133", "name": "C0234133#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}}
{"token": ["The", "duration", "of", "stay", "in", "the", "post-anaesthetic", "care", "unit", "was", "not", "prolonged", "and", "no", "C0234133#ent", "<e1>", "to", "the", "C1254351#ent", "<e2>", "were", "observed", "."], "h": {"id": "C0234133", "name": "C0234133#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["To", "better", "understand", "the", "regulation", "of", "C1335649#ent", "<e1>", ",", "we", "have", "sequenced", "the", "entire", "human", "C0297817#ent", "<e2>"], "h": {"id": "C1335649", "name": "C1335649#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0297817", "name": "C0297817#ent", "pos": [15, 16]}}
{"token": ["Endogenous", "C1537503#ent", "<e1>", "kinase-mediated", "phosphorylation", "of", "C0001477#ent", "<e2>", ",", "phospholamban", ",", "and", "ryanodine", "receptor-Ca(2", "+", ")", "release", "channel", "was", "also", "strongly", "inhibited", "by", "C1537503#ent", "<e1>", "BP", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [6, 7]}}
{"token": ["One", "C0037822#ent", "<e1>", "to", "treating", "C0085084#ent", "<e2>", "finding", "ways", "to", "introduce", "genes", "into", "specific", "neuroglial", "cell", "types"], "h": {"id": "C0037822", "name": "C0037822#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [5, 6]}}
{"token": ["Other", "infectious", "diseases", "with", "C0268381#ent", "<e1>", "are", "less", "common", "(", "C0719022#ent", "<e2>", "mucoyiscidosis", ",", "heroin", "injection-related", "skin", "suppuration", ")", "."], "h": {"id": "C0268381", "name": "C0268381#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [10, 11]}}
{"token": ["The", "dosage", "of", "salicylazosulfapyridine", "and", "C0038317#ent", "<e1>", "she", "was", "taking", ",", "and", "by", "which", "the", "C0009324#ent", "<e2>", "but", "not", "the", "pyoderma", "gangrenosum", "be", "controlled", ",", "was", "not", "increased", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [15, 16]}}
{"token": ["Duchenne", "muscular", "dystrophy", "DMD", ")", "and", "Becker", "muscular", "dystrophy", "C1826421#ent", "<e1>", ")", "are", "two", "allelic", "forms", "of", "an", "C2828000#ent", "<e2>", "phenotypic", "heterogeneity", "."], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2828000", "name": "C2828000#ent", "pos": [18, 19]}}
{"token": ["These", "scintigraphic", "findings", "can", "help", "distinguish", "the", "mildest", "manifestation", "(", "forme", "fruste", "of", "C0025239#ent", "<e1>", "from", "the", "well-ossified", "lesions", "of", "C0040798#ent", "<e2>", "parosteal", "or", "periosteal", "osteosarcoma"], "h": {"id": "C0025239", "name": "C0025239#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040798", "name": "C0040798#ent", "pos": [20, 21]}}
{"token": ["It", "is", "unclear", "whether", "dietary", "arachidonic", "acid", "AA", ")", "and", "docosahexaenoic", "acid", "C2348308#ent", "<e1>", ")", "alter", "the", "circadian", "rhythms", "of", "bone", "turnover", "markers", "C1412791#ent", "<e2>", "OC", ")", "and", "urinary", "N-telopeptide", "NTx", ")", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [23, 24]}}
{"token": ["C2348308#ent", "<e1>", "(", "normalized", "to", "C1412791#ent", "<e2>", ")", "was", "inhibited", "to", "a", "greater", "extent", "in", "soil", "samples", "from", "the", "highly", "contaminated", "site", "in", "low-", "and", "medium-contaminated", "soil", "samples", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [5, 6]}}
{"token": ["The", "amino-acid", "composition", "of", "C0054867#ent", "<e1>", "found", "to", "be", "different", "from", "that", "of", "C0007428#ent", "<e2>", "D."], "h": {"id": "C0054867", "name": "C0054867#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [13, 14]}}
{"token": ["Ten", "patients", "with", "C0221166#ent", "<e1>", "due", "to", "C0031117#ent", "<e2>", "an", "unusual", "symptom", "characterized", "by", "an", "inability", "to", "stand", "still", "despite", "the", "ability", "to", "walk", "."], "h": {"id": "C0221166", "name": "C0221166#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [7, 8]}}
{"token": ["Upper-arm", "weakness", "C0221166#ent", "<e1>", ")", "or", "paralysis", "indicates", "C0031117#ent", "<e2>", "the", "brachial", "plexus", "a", "network", "of", "lower", "cervical", "and", "upper", "thoracic", "spinal", "nerves", "the", "arm", ",", "forearm", ",", "and", "hand", "."], "h": {"id": "C0221166", "name": "C0221166#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "lithium", "(", "C1420713#ent", "<e1>", ")", "on", "brain", "and", "plasma", "levels", "concurrently", "administered", "haloperidol", "(", "C0720810#ent", "<e2>", ")", "were", "investigated", "."], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720810", "name": "C0720810#ent", "pos": [17, 18]}}
{"token": ["These", "differences", "were", "then", "tested", "by", "comparison", "with", "the", "real", "inhibitors", "DX-9065a", "and", "C0048470#ent", "<e1>", ",", "specific", "competitive", "inhibitors", "of", "C2700041#ent", "<e2>", "and", "thrombin", ",", "respectively", ",", "with", "similar", "K(i", ")", "values", "."], "h": {"id": "C0048470", "name": "C0048470#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2700041", "name": "C2700041#ent", "pos": [20, 21]}}
{"token": ["The", "NEP", "inhibitor", "C0070915#ent", "<e1>", "tended", "to", "increase", "the", "sensitivity", "to", "C1705889#ent", "<e2>", "(", "NS", ")", "and", "did", "not", "change", "the", "direction", "of", "the", "response", "."], "h": {"id": "C0070915", "name": "C0070915#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705889", "name": "C1705889#ent", "pos": [11, 12]}}
{"token": ["The", "transplantation", "resulted", "in", "C1840402#ent", "<e1>", "and", "persistent", "C0020437#ent", "<e2>", "."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [8, 9]}}
{"token": ["Twenty", "per", "cent", "of", "the", "patients", "had", "subnormal", "1,25(OH)2D", "concentrations", "while", "55", "%", "had", "biochemical", "evidence", "of", "C1840402#ent", "<e1>", "but", "only", "5", "%", "were", "C0020437#ent", "<e2>", "."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [24, 25]}}
{"token": ["Moreover", ",", "DS", "chains", "purified", "from", "C3541980#ent", "<e1>", "mimicked", "the", "endocan-mediated", "increase", "of", "cell", "proliferation", "the", "presence", "of", "C1524023#ent", "<e2>", "."], "h": {"id": "C3541980", "name": "C3541980#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [18, 19]}}
{"token": ["VEGF-A", "seemed", "to", "be", "a", "specific", "inducer", "of", "C3541980#ent", "<e1>", "transcription", "since", "FGF-2", ",", "PDGF-BB", ",", "C1524023#ent", "<e2>", "and", "EGF", "did", "not", "alter", "expression", "levels"], "h": {"id": "C3541980", "name": "C3541980#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [16, 17]}}
{"token": ["It", "appears", "therefore", "that", "the", "C0017337#ent", "<e1>", "encoding", "lysyl", "oxidase", "a", "C3272401#ent", "<e2>", "a", "common", "evolutionary", "origin", "and", "may", "also", "be", "functionally", "related", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3272401", "name": "C3272401#ent", "pos": [11, 12]}}
{"token": ["Current", "chemotherapy", "of", "choice", "is", "CHOP", "[", "C1161438#ent", "<e1>", ",", "Hydroxydaunomycin", "(", "doxorubicin", ")", ",", "Oncovin", "(", "C0042680#ent", "<e2>", "and", "Prednisone", "]", "."], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042680", "name": "C0042680#ent", "pos": [17, 18]}}
{"token": ["Significant", "therapeutic", "synergism", "against", "P388", "leukemia", "observed", "when", "mitoxantrone", "was", "administered", "on", "the", "same", "day", "as", "methotrexate", "and", "cytarabine", "or", "in", "sequence", "with", "C1161438#ent", "<e1>", ",", "cisplatin", ",", "or", "C0042680#ent", "<e2>"], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0042680", "name": "C0042680#ent", "pos": [29, 30]}}
{"token": ["Furthermore", ",", "the", "C3890011#ent", "<e1>", "a", "synthetic", "growth", "defect", "when", "combined", "with", "either", "C1413259#ent", "<e2>", "-", "22", "or", "wee1", "-", "50", "but", "not", "the", "cdc24", "-", "1", "temperature-sensitive", "mutant", "."], "h": {"id": "C3890011", "name": "C3890011#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413259", "name": "C1413259#ent", "pos": [13, 14]}}
{"token": ["Previously", "we", "isolated", "the", "hOGG1", "gene", "a", "human", "homolog", "of", "the", "C1313359#ent", "<e1>", "which", "encodes", "a", "DNA", "glycosylase", "C0024188#ent", "<e2>", "to", "excise", "oh8Gua", "in", "DNA", "."], "h": {"id": "C1313359", "name": "C1313359#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0024188", "name": "C0024188#ent", "pos": [18, 19]}}
{"token": ["RNA", "polymerase", "II", "kinases", "cyclin-dependent", "kinases-7", "C0255652#ent", "<e1>", ")", "and", "Cdk9", ",", "components", "of", "two", "C1332461#ent", "<e2>", "."], "h": {"id": "C0255652", "name": "C0255652#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332461", "name": "C1332461#ent", "pos": [15, 16]}}
{"token": ["Radixin", "localized", "at", "the", "uropod", "neck", "whereas", "ezrin", "and", "C1417371#ent", "<e1>", "colocalized", "with", "C1420364#ent", "<e2>", "in", "the", "uropod", "."], "h": {"id": "C1417371", "name": "C1417371#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420364", "name": "C1420364#ent", "pos": [13, 14]}}
{"token": ["The", "acquired", "immunodeficiency", "syndrome", "AIDS", ")", "has", "been", "associated", "with", "abnormalities", "of", "adrenocortical", "function", "and", "C0020595#ent", "<e1>", "due", "to", "C0342483#ent", "<e2>", "HHA", ")", "."], "h": {"id": "C0020595", "name": "C0020595#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0342483", "name": "C0342483#ent", "pos": [19, 20]}}
{"token": ["The", "amino", "acid", "composition", "of", "the", "expressed", "C0027203#ent", "<e1>", "agreed", "with", "that", "of", "the", "known", "sequence", "of", "pig", "C0061505#ent", "<e2>", "glutaredoxin", ")", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061505", "name": "C0061505#ent", "pos": [18, 19]}}
{"token": ["Preincubation", "of", "the", "C0027203#ent", "<e1>", "with", "disulfide", "compounds", "the", "C0027203#ent", "<e1>", "from", "inactivation", "by", "iodoacetamide", "but", "inhibited", "the", "C0061505#ent", "<e1>", "the", "absence", "of", "iodoacetamide", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0061505", "name": "C0061505#ent", "pos": [18, 19]}}
{"token": ["In", "an", "experimental", "model", "determining", "blood", "pressure", "compensation", "for", "postural", "tilt", "in", "anesthetized", "rats", ",", "C0074437#ent", "<e1>", "was", "free", "of", "postural", "effects", ",", "while", "C0032912#ent", "<e2>", "induced", "orthostatic", "hypotension"], "h": {"id": "C0074437", "name": "C0074437#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [24, 25]}}
{"token": ["We", "show", "that", "the", "functional", "responses", "of", "freshly", "isolated", "human", "and", "murine", "neutrophils", "to", "C1334126#ent", "<e1>", "chemokines", "are", "significantly", "attenuated", "by", "C1332817#ent", "<e2>", ",", "acting", "via", "CXCR4", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332817", "name": "C1332817#ent", "pos": [21, 22]}}
{"token": ["A", "monoclonal", "antibody", "Yae", ")", "was", "characterized", "and", "shown", "to", "specifically", "recognize", "C1336596#ent", "<e1>", "in", "vivo", "including", "the", "C0289575#ent", "<e2>", "fusion", "gene", "products", ",", "p77E2A-Pbx1", "and", "p85E2A-Pbx1", "."], "h": {"id": "C1336596", "name": "C1336596#ent", "pos": [12, 13]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0289575", "name": "C0289575#ent", "pos": [18, 19]}}
{"token": ["The", "vascular", "relaxation", "induced", "by", "acetylcholine", "or", "C0006945#ent", "<e1>", "was", "similar", "in", "normal", "and", "C0020676#ent", "<e2>", "aortic", "rings"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [14, 15]}}
{"token": ["C0428796#ent", "<e1>", "AVS", ")", "is", "considered", "to", "be", "a", "manifestation", "of", "C0004153#ent", "<e2>", "involves", "the", "aortic", "valve"], "h": {"id": "C0428796", "name": "C0428796#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [11, 12]}}
{"token": ["All", "the", "phenothiazines", "used", "produced", "mammary", "growth", "the", "intensity", "sequence", "thioridazine", "greater", "than", "chlorpromazine", "greater", "than", "C0033405#ent", "<e1>", "greater", "than", "C0033459#ent", "<e2>", "greater", "than", "perphenazine", "greater", "than", "levomethiomeprazine", "."], "h": {"id": "C0033405", "name": "C0033405#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0033459", "name": "C0033459#ent", "pos": [20, 21]}}
{"token": ["Transient", ",", "isolated", "and", "severe", "C0268487#ent", "<e1>", "of", "protein", "S", "been", "reported", "in", "patients", "with", "C0085650#ent", "<e2>", "a", "previous", "preparatory", "infection", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085650", "name": "C0085650#ent", "pos": [15, 16]}}
{"token": ["Protein", "C", "a", "vitamin", "K-dependent", "plasma", "protein", "zymogen", "whose", "genetic", "mild", "severe", "C0268487#ent", "<e1>", "are", "linked", "with", "risk", "for", "venous", "thrombosis", "neonatal", "C0085650#ent", "<e2>", "respectively", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085650", "name": "C0085650#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "steady-state", "pharmacokinetics", "and", "disposition", "of", "C0245514#ent", "<e1>", "and", "its", "metabolites", "in", "patients", "with", "C0011860#ent", "<e2>", "similar", "to", "those", "in", "healthy", "subjects"], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [15, 16]}}
{"token": ["C0245514#ent", "<e1>", ",", "a", "novel", "thiazolidinedione", "drug", "to", "treat", "C0011860#ent", "<e2>", "is", "a", "selective", "ligand", "for", "the", "peroxisome", "proliferator-activated", "receptor-gamma", "PPARgamma", ")", "."], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [9, 10]}}
{"token": ["The", "C0005779#ent", "<e1>", "identified", "as", "\"", "C0272340#ent", "<e2>"], "h": {"id": "C0005779", "name": "C0005779#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0272340", "name": "C0272340#ent", "pos": [6, 7]}}
{"token": ["4", ")", "This", "suggests", "the", "existence", "of", "an", "IRS-1-independent", "pathway", "leading", "to", "the", "activation", "of", "C3714973#ent", "<e1>", "Akt", ",", "and", "C1419748#ent", "<e2>", ")", ";", "GLUT4", "translocation", ";", "and", "glucose", "transport"], "h": {"id": "C3714973", "name": "C3714973#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419748", "name": "C1419748#ent", "pos": [20, 21]}}
{"token": ["Mutation", "of", "C2346452#ent", "<e1>", "or", "AP-1", "binding", "sites", "in", "the", "context", "of", "the", "C1567160#ent", "<e2>", "promoter", "demonstrated", "that", "both", "sites", "participate", "in", "dexamethasone-mediated", "inhibition", "of", "the", "C1567160#ent", "<e2>", "promoter", "activity"], "h": {"id": "C2346452", "name": "C2346452#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1567160", "name": "C1567160#ent", "pos": [13, 14]}}
{"token": ["The", "induction", "of", "RAR", "beta", "expression", "by", "the", "ciglitazone", "and", "C0254507#ent", "<e1>", "combination", "was", "diminished", "by", "a", "PPAR", "gamma-selective", "antagonist", ",", "C0058021#ent", "<e2>"], "h": {"id": "C0254507", "name": "C0254507#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0058021", "name": "C0058021#ent", "pos": [21, 22]}}
{"token": ["An", "85-year-old", ",", "C0362046#ent", "<e1>", "man", "is", "described", "with", "necrotizing", "(", "malignant", ")", "C0021355#ent", "<e2>"], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021355", "name": "C0021355#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", "TFIIH", "participates", "in", "Vpr", "'s", "C1705401#ent", "<e1>", "coactivating", "activity", "at", "a", "step", "beyond", "its", "interaction", "with", "C1366462#ent", "<e2>", "."], "h": {"id": "C1705401", "name": "C1705401#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366462", "name": "C1366462#ent", "pos": [20, 21]}}
{"token": ["Blockade", "by", "virus", "infection", "the", "inhibitory", "effect", "of", "C0075584#ent", "<e1>", "was", "reversed", "when", "the", "concentrations", "of", "C0001644#ent", "<e2>", "increased", "."], "h": {"id": "C0075584", "name": "C0075584#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [16, 17]}}
{"token": ["For", "distilled", "liquors", ",", "a", "partial", "least-squares", "C0030360#ent", "<e1>", ")", "calibration", "was", "developed", "for", "C0001975#ent", "<e2>", "on", "the", "SB-ATR/FTIR", "spectra", "of", "mixtures", "of", "ethanol", "and", "distilled", "water"], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "glutamine", "and", "PMA", "on", "the", "expression", "of", "the", "NADPH", "oxidase", "components", "p22", "phox", ")", ",", "C3811755#ent", "<e1>", "(", "phox", ")", "and", "C1423827#ent", "<e2>", "(", "phox", ")", "were", "also", "determined", "."], "h": {"id": "C3811755", "name": "C3811755#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1423827", "name": "C1423827#ent", "pos": [24, 25]}}
{"token": ["We", "show", "that", "K.", "lactis", "telomeres", "are", "able", "to", "repress", "the", "transcription", "of", "a", "C0079429#ent", "<e1>", "located", "at", "the", "junction", "between", "the", "C1336604#ent", "<e2>", "the", "subtelomeric", "domain", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1336604", "name": "C1336604#ent", "pos": [22, 23]}}
{"token": ["Likewise", ",", "expression", "of", "dominant", "negative", "forms", "of", "Ras", "or", "C0139905#ent", "<e1>", "completely", "blocked", "C4082284#ent", "<e2>", "CREB", "transcriptional", "activity"], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [14, 15]}}
{"token": ["ECs", "transfected", "with", "a", "dominant", "negative", "mutant", "of", "C0139905#ent", "<e1>", "(", "Raf301", ")", "or", "the", "catalytically", "inactive", "mutant", "of", "C4082284#ent", "<e2>", "mERK2", ")", "diminished", "strain-induced", "promoter", "activities"], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [19, 20]}}
{"token": ["Signaling", "via", "the", "Ras", "pathway", "sequential", "activation", "of", "Ras", ",", "C0139905#ent", "<e1>", ",", "mitogen-activated", "protein", "kinase", "kinase", "MKK", ")", ",", "and", "the", "C4082284#ent", "<e2>", "ERK", ")", "group", "of", "mitogen-activated", "protein", "MAP", ")", "kinases", "."], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [22, 23]}}
{"token": ["Specific", "changes", "in", "mandibular", "movement", "were", "related", "to", "the", "presence", "of", "pain", ",", "C0231218#ent", "<e1>", "and", "other", "symptoms", "of", "the", "C0543968#ent", "<e2>"], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0543968", "name": "C0543968#ent", "pos": [20, 21]}}
{"token": ["C1419330#ent", "<e1>", "intoxication", "in", "rats", "included", "C0542037#ent", "<e2>", ",", "behavioral", "changes", ",", "and", "mortality", "."], "h": {"id": "C1419330", "name": "C1419330#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0542037", "name": "C0542037#ent", "pos": [6, 7]}}
{"token": ["Tumor", "cells", "C1413108#ent", "<e1>", ",", "lacking", "CR1", "or", "C3272447#ent", "<e2>", ",", "and", "undergoing", "no", "C3", "deposition", ",", "may", "escape", "C", "attack", "to", "the", "compensatory", "effect", "of", "C1413108#ent", "<e1>", "in", "the", "absence", "of", "the", "other", "regulatory", "proteins"], "h": {"id": "C1413108", "name": "C1413108#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3272447", "name": "C3272447#ent", "pos": [8, 9]}}
{"token": ["Villous", "cytotrophoblast", "cells", "expressed", "C1413108#ent", "<e1>", "but", "were", "largely", "devoid", "of", "C3272447#ent", "<e2>", "."], "h": {"id": "C1413108", "name": "C1413108#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3272447", "name": "C3272447#ent", "pos": [11, 12]}}
{"token": ["We", "have", "identified", "based", "on", "gene", "cluster", "analysis", "the", "genes", "between", "Rv3799-Rv3807", "in", "M.", "tuberculosis", "orthologs", "in", "C0010153#ent", "<e1>", ",", "Mycobacteria", "and", "C0002962#ent", "<e2>", "(", "CMN", ")", "genomes", "."], "h": {"id": "C0010153", "name": "C0010153#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [22, 23]}}
{"token": ["C0010153#ent", "<e1>", "belong", "to", "a", "distinct", "Gram-positive", "group", "bacteria", "including", "mycobacteria", "and", "C0002962#ent", "<e2>", ",", "which", "are", "characterized", "by", "the", "presence", "of", "mycolic", "acids", "their", "cell", "wall"], "h": {"id": "C0010153", "name": "C0010153#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [12, 13]}}
{"token": ["As", "with", "other", "bacteria", "belonging", "to", "the", "C0010153#ent", "<e1>", ",", "mycobacteria", ",", "and", "nocardia", "group", "C0002962#ent", "<e2>", "possess", "in", "their", "cell", "walls", "neutral", "polysaccharide"], "h": {"id": "C0010153", "name": "C0010153#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [15, 16]}}
{"token": ["The", "human", "ABO(H)", "blood", "group", "and", "B", "antigens", "generated", "by", "the", "homologous", "glycosyltransferases", "A", "C2697657#ent", "<e1>", ")", "and", "B", "(", "C3537450#ent", "<e2>", ")", ",", "which", "add", "the", "monosaccharides", "GalNAc", "Gal", ",", "respectively", ",", "to", "the", "cell-surface", "H", "antigens"], "h": {"id": "C2697657", "name": "C2697657#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3537450", "name": "C3537450#ent", "pos": [20, 21]}}
{"token": ["C2697657#ent", "<e1>", "and", "C3537450#ent", "<e2>", "utilize", "a", "common", "acceptor", ",", "the", "H", "antigen", "disaccharide", "-", "->2)-beta-d-Galp-OR", ",", "but", "different", "donors", ",", "where", "C2697657#ent", "<e1>", "transfers", "GalNAc", "from", "UDP-GalNAc", "and", "C3537450#ent", "<e2>", "transfers", "Gal", "from", "UDP-Gal", "."], "h": {"id": "C2697657", "name": "C2697657#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537450", "name": "C3537450#ent", "pos": [3, 4]}}
{"token": ["The", "C0020429#ent", "<e1>", "caused", "by", "PGD2", "was", "blocked", "by", "para-chlorophenylalanine", ",", "C0354872#ent", "<e2>", "or", "phenoxybenzamine", "."], "h": {"id": "C0020429", "name": "C0020429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0354872", "name": "C0354872#ent", "pos": [11, 12]}}
{"token": ["C0282211#ent", "<e1>", "was", "intravenously", "infused", "and", "prevented", "C0042510#ent", "<e2>", "episodes", ",", "but", "C0042510#ent", "<e2>", "recurred", "after", "every", "attempt", "of", "drug", "discontinuation"], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [7, 8]}}
{"token": ["This", "research", "demonstrates", "that", "the", "C0022575#ent", "<e1>", "melanosomes", "of", "Rana", "esculenta", "possess", "a", "C1420718#ent", "<e2>", "(", "TH", ")", "activity", ",", "showing", "that", "a", "tyrosinase", "is", "the", "enzyme", "involved", "in", "the", "melanogenesis", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [13, 14]}}
{"token": ["C0006378#ent", "<e1>", "was", "the", "C0003195#ent", "<e2>", "frequently", "used", "(", "23", "cases", ",", "34", "%", ")", "with", "a", "high", "percentage", "of", "success", "(", "87", "%", ")", "."], "h": {"id": "C0006378", "name": "C0006378#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [4, 5]}}
{"token": ["C0006378#ent", "<e1>", "has", "therefore", "unquestionable", "C0003195#ent", "<e2>", "properties", "and", "it", "can", "have", "a", "double", "action", ";", "with", "higher", "dosages", "its", "action-quinidine-like-is", "predominant", "at", "the", "atrial", "level"], "h": {"id": "C0006378", "name": "C0006378#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "C0246957#ent", "<e1>", "was", "expressed", "at", "high", "levels", "in", "several", "tumor", "cell", "lines", "C1413287#ent", "<e2>", "was", "ectopically", "expressed", "in", "two", "sarcoma", "lines", "suggesting", "a", "possible", "involvement", "of", "these", "two", "Cdks", "in", "oncogenesis", "."], "h": {"id": "C0246957", "name": "C0246957#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413287", "name": "C1413287#ent", "pos": [15, 16]}}
{"token": ["Immunoprecipitation", "experiments", "that", "p27Kip1", "protein", "associates", "with", "Cdk2", "and", "C0246957#ent", "<e1>", ",", "but", "not", "with", "C1413287#ent", "<e2>", "."], "h": {"id": "C0246957", "name": "C0246957#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413287", "name": "C1413287#ent", "pos": [15, 16]}}
{"token": ["C0950828#ent", "<e1>", "generally", "showed", "activities", "twofold", "or", "greater", "than", "those", "of", "C0008809#ent", "<e2>", "and", "the", "other", "drugs", "against", "almost", "all", "members", "of", "the", "family", "Enterobacteriaceae"], "h": {"id": "C0950828", "name": "C0950828#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [11, 12]}}
{"token": ["The", "C1414435#ent", "<e1>", "activity", "is", "generally", "increased", "in", "cases", "of", "C0085166#ent", "<e2>", "and", "in", "women", "with", "BV", "and", "chlamydial", "cervicitis"], "h": {"id": "C1414435", "name": "C1414435#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085166", "name": "C0085166#ent", "pos": [10, 11]}}
{"token": ["Immunoblot", "analysis", "antibodies", "specific", "to", "15(S)-lipoxygenase-1", "(", "LOX-1", ")", "and", "15(S)-lipoxygenase-2", "(", "C1540289#ent", "<e1>", ")", "demonstrated", "the", "expression", "of", "C1412360#ent", "<e2>", ",", "but", "not", "15-LOX-1", ",", "in", "these", "tumor", "cells"], "h": {"id": "C1540289", "name": "C1540289#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412360", "name": "C1412360#ent", "pos": [19, 20]}}
{"token": ["Respectively", ",", "207", "and", "119", "HIV-infected", "patients", "were", "admitted", "for", "C0035242#ent", "<e1>", "era", "1", "and", "C1414461#ent", "<e2>"], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [15, 16]}}
{"token": ["Interestingly", ",", "the", "effect", "of", "retinoic", "acid", "C1415659#ent", "<e1>", "expression", "was", "not", "observed", "in", "a", "C1415658#ent", "<e2>", "mutant", "background", "."], "h": {"id": "C1415659", "name": "C1415659#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415658", "name": "C1415658#ent", "pos": [15, 16]}}
{"token": ["The", "primary", "structures", "urokinase", "and", "C0032143#ent", "<e1>", "are", "known", ";", "both", "C3540017#ent", "<e2>", "have", "been", "synthesized", "by", "DNA", "technology"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [11, 12]}}
{"token": ["The", "recommendations", "for", "MV", "surgery", "in", "ischemic", "MR", "acute", "post-infarction", "MR", "with", "cardiogenic", "shock", "C0002965#ent", "<e1>", "persistent", "moderate-severe", "and", "severe", "MR", "and", "chronic", ",", "C0007193#ent", "<e2>", "moderate-severe", "and", "severe", "MR", "."], "h": {"id": "C0002965", "name": "C0002965#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007193", "name": "C0007193#ent", "pos": [24, 25]}}
{"token": ["Additionally", ",", "C1412794#ent", "<e1>", "Hcy", ")", "methyltransferase", "(", "C1530585#ent", "<e2>", ")", "activity", "decreased", "linearly", "(", "P", "<", "0.05", ")", ",", "whereas", "plasma", "total", "Hcy", "remained", "unchanged", "."], "h": {"id": "C1412794", "name": "C1412794#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1530585", "name": "C1530585#ent", "pos": [8, 9]}}
{"token": ["To", "confirm", "the", "infiltration", "of", "hsp60-reactive", "T-cell", "clones", "into", "C0031099#ent", "<e1>", "lesions", ",", "nucleotide", "sequences", "complementarity-determining", "region", "of", "the", "T-cell", "receptor", "TCR", ")", "C0544483#ent", "<e2>", "were", "compared", "between", "hsp60-reactive", "peripheral", "blood", "T", "cells", "C0031099#ent", "<e1>", "lesion-infiltrating", "T", "cells", "."], "h": {"id": "C0544483", "name": "C0544483#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0031099", "name": "C0031099#ent", "pos": [9, 10]}}
{"token": ["This", "is", "particularly", "significant", "since", "C1420388#ent", "<e1>", ",", "a", "Smad4", "adaptor", "protein", "possesses", "potent", "C0079427#ent", "<e2>", "is", "frequently", "seen", "to", "be", "inactivated", "in", "carcinogenic", "gastric", "cells", "."], "h": {"id": "C1420388", "name": "C1420388#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [14, 15]}}
{"token": ["Transforming", "growth", "factor-beta", "TGF-beta", ")", "signaling", "members", "TGF-beta", "receptor", "type", "II", "TBRII", ")", ",", "Smad2", ",", "Smad4", "and", "Smad", "adaptor", "embryonic", "liver", "fodrin", "(", "C1420388#ent", "<e1>", ")", ",", "are", "prominent", "C0079427#ent", "<e2>", "gastrointestinal", "cancers"], "h": {"id": "C1420388", "name": "C1420388#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [30, 31]}}
{"token": ["In", "this", "cellular", "setting", "CoAA", "directly", "represses", "the", "proto-oncogene", "c-myc", "recruiting", "C1098658#ent", "<e1>", "decreasing", "both", "the", "acetylation", "of", "histone", "H3", "the", "presence", "of", "C0035680#ent", "<e2>", "the", "c-myc", "promoter", "."], "h": {"id": "C1098658", "name": "C1098658#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [23, 24]}}
{"token": ["Plasma", "concentration", "data", "are", "presented", "from", "4", "illustrative", "patients", "enrolled", "in", "a", "dose-ranging", "randomised", "clinical", "trial", "comparing", "C0012373#ent", "<e1>", "with", "placebo", "for", "the", "prevention", "of", "C0239377#ent", "<e2>", "vaso-occlusive", "crises", "sickle", "cell", "disease"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [25, 26]}}
{"token": ["Values", "were", "normal", "in", "eight", "patients", "with", "membranous", "glomerulonephritis", "four", "with", "chronic", "glomerulonephritis", "one", "with", "C0027706#ent", "<e1>", "as", "well", "as", "in", "patients", "with", "other", "renal", "diseases", "C0029896#ent", "<e2>", "of", "non-renal", "origin", "."], "h": {"id": "C0027706", "name": "C0027706#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [26, 27]}}
{"token": ["Sidekick-1", ",", "a", "cell", "adhesion", "molecule", "the", "C1425097#ent", "<e1>", "is", "up-regulated", "in", "glomerular", "podocytes", "the", "C2749515#ent", "<e2>", "HIV-associated", "nephropathy", "HIVAN", ")", "."], "h": {"id": "C1425097", "name": "C1425097#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2749515", "name": "C2749515#ent", "pos": [15, 16]}}
{"token": ["Subsequent", "discovery", "of", "the", "oncogenic", "nature", "of", "C0104940#ent", "<e1>", "to", "the", "escalation", "of", "drug", "discovery", "revolving", "around", "MEK", "and", "C1706586#ent", "<e2>", "."], "h": {"id": "C0104940", "name": "C0104940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [19, 20]}}
{"token": ["The", "intensity", "of", "staining", "obtained", "with", "serial", "dilutions", "of", "the", "antibodies", "indicated", "that", "the", "cytoplasmic", "concentration", "of", "C0104940#ent", "<e1>", "tended", "to", "be", "higher", "than", "that", "of", "C1706586#ent", "<e2>"], "h": {"id": "C0104940", "name": "C0104940#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [26, 27]}}
{"token": ["By", "contrast", ",", "the", "PGF2", "C0171965#ent", "<e1>", "contractions", "of", "rabbit", "arteries", "were", "not", "enhanced", "by", "the", "C3536910#ent", "<e2>"], "h": {"id": "C0171965", "name": "C0171965#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536910", "name": "C3536910#ent", "pos": [16, 17]}}
{"token": ["To", "clarify", "whether", "C1419771#ent", "<e1>", "is", "essential", "for", "chondrocytic", "differentiation", "secondary", "cartilages", "we", "performed", "an", "organ", "culture", "system", "C0236000#ent", "<e2>", "explants", "derived", "from", "Runx2-/-", "mice", "at", "embryonic", "day", "."], "h": {"id": "C1419771", "name": "C1419771#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0236000", "name": "C0236000#ent", "pos": [18, 19]}}
{"token": ["C0033216#ent", "<e1>", "and", "seven", "other", "C0002934#ent", "<e2>", "reversible", "or", "quasi-reversible", "voltammograms", "at", "the", "NB/W", "interface", "in", "the", "pH", "range", "between", "0.9", "and", "9.6", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002934", "name": "C0002934#ent", "pos": [5, 6]}}
{"token": ["C0033216#ent", "<e1>", "and", "lidocaine", "are", "typical", "C0002934#ent", "<e2>", "known", "to", "interact", "with", "cell", "membranes", "alterations", "in", "the", "structural", "and", "functional", "organization", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002934", "name": "C0002934#ent", "pos": [6, 7]}}
{"token": ["Using", "a", "biosensor", ",", "we", "establish", "that", "C0006931#ent", "<e1>", ",", "unlike", "mustard", "oil", "consistently", "activates", "C0031671#ent", "<e2>", "sensory", "neurons", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [15, 16]}}
{"token": ["C0022104#ent", "<e1>", "patients", "have", "a", "markedly", "elevated", "risk", "for", "developing", "C0030305#ent", "<e2>", "well", "as", "pancreatic", "insufficiency"], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [10, 11]}}
{"token": ["Stimulation", "of", "HT29", "cells", "C0812246#ent", "<e1>", "and", "IL-1beta", "resulted", "in", "reversible", "down-regulation", "of", "C1419891#ent", "<e2>", "at", "both", "protein", "and", "mRNA", "levels", "but", "little", "effect", "was", "observed", "with", "IL-6", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419891", "name": "C1419891#ent", "pos": [13, 14]}}
{"token": ["The", "C1333922#ent", "<e1>", "component", "of", "the", "C3274736#ent", "<e2>", "fusion", "protein", "protected", "from", "cullin-4A-mediated", "ubiquitination", "and", "subsequent", "proteasome-dependent", "degradation"], "h": {"id": "C1333922", "name": "C1333922#ent", "pos": [1, 2]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274736", "name": "C3274736#ent", "pos": [6, 7]}}
{"token": ["Using", "Hoxa9(-/-", ")", "marrow", ",", "we", "demonstrate", "that", "expression", "of", "C1333922#ent", "<e1>", "is", "not", "required", "for", "myeloid", "immortalization", "C3274736#ent", "<e2>", "."], "h": {"id": "C1333922", "name": "C1333922#ent", "pos": [10, 11]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274736", "name": "C3274736#ent", "pos": [18, 19]}}
{"token": ["On", "the", "basis", "of", "the", "discovery", "that", "the", "leukemogenic", "gene", "C1333922#ent", "<e1>", "can", "also", "expand", "hematopoietic", "stem", "cells", "we", "compared", "the", "ability", "of", "C3274736#ent", "<e2>", "that", "of", "HOXB4", "to", "trigger", "HSC", "expansion", "in", "vitro"], "h": {"id": "C1333922", "name": "C1333922#ent", "pos": [10, 11]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274736", "name": "C3274736#ent", "pos": [23, 24]}}
{"token": ["1", "In", "a", "placebo-controlled", "study", "the", "respective", "anti-hypertensive", "effects", "C0020261#ent", "<e1>", "and", "C0020261#ent", "<e1>", "plus", "the", "beta-adrenoceptor", "blocker", "C0000946#ent", "<e1>", "were", "assessed", "in", "18", "patients", "with", "moderately", "severe", "essential", "hypertension", "."], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0000946", "name": "C0000946#ent", "pos": [18, 19]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "nitric", "oxide", "in", "the", "increase", "in", "local", "cerebral", "blood", "flow", "C1428360#ent", "<e1>", ")", "caused", "by", "infusion", "of", "C0022614#ent", "<e2>", "in", "anesthetized", "newborn", "sheep", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [22, 23]}}
{"token": ["We", "report", "a", "case", "of", "a", "man", "aged", "36", ",", "in", "whom", "a", "diagnosis", "of", "C0010674#ent", "<e1>", "was", "diagnosed", "based", "on", "the", "association", "of", "C0006267#ent", "<e2>", "obstructive", "azoospermia"], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [24, 25]}}
{"token": ["Beneficial", "effects", "on", "the", "prognosis", "of", "the", "patients", "with", "mild", "to", "moderate", "C0018802#ent", "<e1>", "been", "obtained", "with", "C0025859#ent", "<e2>", ",", "bisoprolol", ",", "and", "carvedilol", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [17, 18]}}
{"token": ["Ten", "patients", "with", "typical", "angina", "pectoris", "without", "hypertension", ",", "C0018802#ent", "<e1>", "other", "disease", "were", "treated", "with", "four-week", "courses", "of", "C0025859#ent", "<e2>", "(", "alpha", "beta1", "cardioselective", "beta-blocking", "agent", ",", "propranolol", "and", "placebo", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [19, 20]}}
{"token": ["C2718001#ent", "<e1>", "of", "the", "neuronal", "protein", "alpha-synuclein", "C1258847#ent", "<e2>", ")", "is", "implicated", "in", "PD", "."], "h": {"id": "C2718001", "name": "C2718001#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [7, 8]}}
{"token": ["An", "immunoblot", "assay", "detecting", "C0065082#ent", "<e1>", "in", "agar-incorporated", ",", "lysed", "C1420193#ent", "<e2>", "developed", ",", "and", "28", "defined", ",", "clinical", "isolates", "Listeria", "monocytogenes", "examined", "for", "toxin", "production", "."], "h": {"id": "C0065082", "name": "C0065082#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [10, 11]}}
{"token": ["The", "increases", "in", "mRNAs", "for", "C1705592#ent", "<e1>", "and", "IL-6", "were", "abrogated", "by", "addition", "of", "NF-kappaB", "and", "C1449702#ent", "<e2>", "suggesting", "that", "the", "upregulation", "of", "C1705592#ent", "<e1>", "and", "IL-6", "is", "mediated", "through", "NF-kappaB", "and", "MAP", "kinase", "signaling", "pathways"], "h": {"id": "C1449702", "name": "C1449702#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [5, 6]}}
{"token": ["We", "found", "no", "increase", "in", "the", "frequencies", "of", "the", "C3890192#ent", "<e1>", "or", "DR5", "antigens", "in", "patients", "with", "C1832588#ent", "<e2>", "."], "h": {"id": "C3890192", "name": "C3890192#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1832588", "name": "C1832588#ent", "pos": [17, 18]}}
{"token": ["The", "in", "vitro", "activities", "of", "magainin", "analogs", "against", "C0085313#ent", "<e1>", "Entamoeba", "histolytica", "and", "Trypanosoma", "cruzi", "assessed", "by", "C0162572#ent", "<e2>", "morphological", "integrity", "and", "motility", "."], "h": {"id": "C0085313", "name": "C0085313#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162572", "name": "C0162572#ent", "pos": [17, 18]}}
{"token": ["Studies", "were", "performed", "on", "the", "production", "of", "rifamycin", "SV", "an", "ansamycin", "compound", ",", "extensively", "used", "for", "C0041296#ent", "<e1>", "leprosy", "and", "several", "other", "C0026918#ent", "<e2>", "using", "a", "strain", "of", "Amycolatopsis", "mediterranei", "in", "solid", "cultures"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [22, 23]}}
{"token": ["The", "genetic", "polymorphisms", "aldehyde", "dehydrogenase-2", "ALDH2", ")", ",", "alcohol", "dehydrogenase-2", "ADH2", ")", ",", "C3811648#ent", "<e1>", ",", "and", "glutathione", "S-transferase", "M1", "GSTM1", ")", "influence", "the", "metabolism", "of", "C0001975#ent", "<e2>", "and", "other", "carcinogens", "."], "h": {"id": "C3811648", "name": "C3811648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [26, 27]}}
{"token": ["Because", "alcohol", "dehydrogenase", "3", "C3811648#ent", "<e1>", ")", "is", "rate-limiting", "in", "C0001975#ent", "<e2>", "is", "polymorphic", ",", "we", "examined", "C3811648#ent", "<e1>", "genotype", "in", "relation", "to", "alcohol", "intake", "breast", "cancer", "risk", "."], "h": {"id": "C3811648", "name": "C3811648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [10, 11]}}
{"token": ["Recent", "studies", "indicate", "that", "neuroprotection", "afforded", "by", "brain-derived", "neurotrophic", "factor", "BDNF", ")", "is", "mediated", "by", "C4082284#ent", "<e1>", "ERK", ")", "and", "phosphatidylinositol-3", "kinase", "C1709402#ent", "<e2>", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [22, 23]}}
{"token": ["Although", "CpG", "DNA", "p38", "mitogen-activated", "protein", "kinase", ",", "C4082284#ent", "<e1>", "and", "phosphatidylinositide-3'-OH", "kinase", "C1709402#ent", "<e2>", ",", "only", "the", "blocking", "of", "C1709402#ent", "<e2>", "inhibited", "the", "CpG", "DNA-induced", "DC", "survival", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [13, 14]}}
{"token": ["The", "serotonin", "agonists", "5-hydroxytryptophan", "C0028362#ent", "<e1>", "and", "5-methoxy-N", ",", "N-dimethyltryptamine", "abolish", "the", "inducing", "effect", "of", "C0035179#ent", "<e2>", "."], "h": {"id": "C0028362", "name": "C0028362#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [15, 16]}}
{"token": ["Mild", "leukopenia", "C0023530#ent", "<e1>", "developed", "in", "one", "patient", "and", "slight", "C0014457#ent", "<e2>", "in", "four", "patients", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [10, 11]}}
{"token": ["Laboratory", "findings", "anaemia", ",", "leukopenia", ",", "C0023530#ent", "<e1>", ",", "lymphocytopenia", ",", "monocytosis", ",", "C0014457#ent", "<e2>", ",", "thrombocytopenia", "and", "pancytopenia", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [13, 14]}}
{"token": ["Along", "with", "C1417694#ent", "<e1>", ",", "myocyte", "enhancer", "factor-2D", "MEF-2D", ")", "and", "the", "myogenic", "transcription", "factor", "C1417574#ent", "<e2>", "transactivated", "the", "MyHCbeta", "promoter", "in", "calcium-ionophore-treated", "myotubes", "in", "a", "calcineurin-dependent", "manner", "."], "h": {"id": "C1417694", "name": "C1417694#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [15, 16]}}
{"token": ["Again", ",", "the", "EGTA-crude", "induced", "FA", "in", "C1335621#ent", "<e1>", "when", "retreated", "with", "2mM", "C3710848#ent", "<e2>", "after", "elimination", "of", "EGTA", "."], "h": {"id": "C1335621", "name": "C1335621#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3710848", "name": "C3710848#ent", "pos": [13, 14]}}
{"token": ["A", "method", "for", "the", "differential-pulse", "polarographic", "determination", "of", "nifedipine", "has", "been", "developed", ",", "based", "on", "the", "electrochemistry", "of", "the", "C0772162#ent", "<e1>", "group", "in", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C0772162", "name": "C0772162#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [24, 25]}}
{"token": ["Effects", "of", "C0017887#ent", "<e1>", "GTN", ")", "were", "studied", "in", "ten", "patients", "without", "C0018802#ent", "<e2>", "diagnostic", "cardiac", "catheterisation", "angiography", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}}
{"token": ["C0041351#ent", "<e1>", "is", "a", "C0311376#ent", "<e2>", "has", "rarely", "been", "reported", "in", "transplant", "recipients", "."], "h": {"id": "C0041351", "name": "C0041351#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0311376", "name": "C0311376#ent", "pos": [4, 5]}}
{"token": ["Tau", "is", "known", "to", "be", "phosphorylated", "by", "several", "C0031727#ent", "<e1>", "such", "as", "C0752312#ent", "<e2>", "microtubule", "affinity", "regulating", "kinase", "and", "protein", "kinase", "A.", "found", "a", "putative", "serum-", "and", "glucocorticoid-induced", "protein", "kinase", "1", "SGK1", ")", "phosphorylation", "site", "within", "the", "207GSRSRTPSLP216", "tau", "amino", "acid", "sequence"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [12, 13]}}
{"token": ["Gastrointestinal", "inflammation", "infection", "can", "be", "associated", "with", "forms", "of", "arthritis", ",", "such", "as", ",", "acute", "reactive", "arthritis", "by", "enteritis", "due", "to", "C0085423#ent", "<e1>", "ankylosing", "spondylitis", "peripheral", "arthritis", "relation", "to", "C0010346#ent", "<e2>", "ulcerative", "colitis"], "h": {"id": "C0085423", "name": "C0085423#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [29, 30]}}
{"token": ["These", "findings", "indicate", "that", "defective", "fatty", "acid", "oxidation", "C3241937#ent", "<e1>", "caused", "by", "methionine", "and", "C0162429#ent", "<e2>", "further", "establishes", "the", "role", "of", "long", "chain", "very", "long", "chain", "fatty", "acids", "the", "pathogenesis", "of", "C3241937#ent", "<e1>", "."], "h": {"id": "C3241937", "name": "C3241937#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [14, 15]}}
{"token": ["C3891713#ent", "<e1>", "infection", "also", "induced", "the", "expression", "of", "lymphatic", "markers", "Prox-1", "and", "C3537357#ent", "<e2>", "as", "early", "as", "8", "h", "p.i", "."], "h": {"id": "C3891713", "name": "C3891713#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537357", "name": "C3537357#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "HepG2", "C3A", "cells", "C2984141#ent", "<e1>", "underwent", "apoptosis", "in", "the", "presence", "of", "recombinant", "C1415195#ent", "<e2>", "in", "both", "concentration", "and", "time-dependant", "manner", "."], "h": {"id": "C2984141", "name": "C2984141#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415195", "name": "C1415195#ent", "pos": [14, 15]}}
{"token": ["The", "human", "epithelial", "proteinase", "SKALP/elafin", "and", "the", "porcine", "sodium-potassium", "ATPase", "inhibitor", "C3887675#ent", "<e1>", "are", "two", "highly", "C1334043#ent", "<e2>", "share", "an", "NH2-terminal", "transglutaminase", "substrate", "domain", "a", "COOH-terminal", "whey", "acidic", "protein", "(", "WAP", ")", "domain", "."], "h": {"id": "C3887675", "name": "C3887675#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}}
{"token": ["Studying", "the", "genome", "structure", "C0872909#ent", "<e1>", "has", "been", "hindered", "by", "their", "large", "C0017428#ent", "<e2>", "and", "uniform", "karyotypes", "."], "h": {"id": "C0872909", "name": "C0872909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [12, 13]}}
{"token": ["The", "resulting", "Ca2", "+", "influx", "contributes", "to", "the", "component", "of", "C0051844#ent", "<e1>", "II-induced", "contraction", "that", "is", "equally", "sensitive", "to", "chloride", "or", "C0006684#ent", "<e2>"], "h": {"id": "C0051844", "name": "C0051844#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [21, 22]}}
{"token": ["Wnts", "are", "C0536221#ent", "<e1>", "act", "through", "the", "C1414886#ent", "<e2>", "regulate", "proliferation", ",", "apoptosis", ",", "branching", "morphogenesis", "inductive", "processes", ",", "and", "cell", "polarity"], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414886", "name": "C1414886#ent", "pos": [7, 8]}}
{"token": ["Beta-catenin", "is", "a", "C0536221#ent", "<e1>", "is", "activated", "by", "signaling", "through", "C1414886#ent", "<e2>"], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414886", "name": "C1414886#ent", "pos": [10, 11]}}
{"token": ["To", "compare", "the", "efficacy", "of", "7", "%", "NaCl", "solution", "hypertonic", "saline", "in", "6", "%", "dextran", "70", "solution", "C3890918#ent", "<e1>", ")", "with", "that", "of", "C0073385#ent", "<e2>", "LRS", ")", "for", "treatment", "of", "dogs", "in", "traumatic", "shock"], "h": {"id": "C3890918", "name": "C3890918#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0073385", "name": "C0073385#ent", "pos": [23, 24]}}
{"token": ["In", "particular", ",", "the", "role", "of", "Tac1p", ",", "the", "main", "C.", "albicans", "C1418444#ent", "<e1>", "regulator", ",", "in", "the", "progesterone", "response", "apparently", "restricted", "to", "five", "C1417679#ent", "<e2>", "."], "h": {"id": "C1418444", "name": "C1418444#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["Thus", ",", "PARP", "inhibition", "is", "C0242912#ent", "<e1>", "and", "regulates", "the", "ischemic", "nuclear", "translocation", "of", "C1826618#ent", "<e2>", "in", "stroke", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826618", "name": "C1826618#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "C1423842#ent", "<e1>", "cytokines", "may", "have", "new", "important", "roles", "in", "resistance", "to", "C0001342#ent", "<e2>", ",", "acting", "directly", "on", "osteoclasts", "or", "indirectly", "through", "B", "cells"], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001342", "name": "C0001342#ent", "pos": [15, 16]}}
{"token": ["C0002878#ent", "<e1>", "postnatally", "acquired", "C0035920#ent", "<e2>", "first", "was", "reported", "by", "Sato", "et", "al.", "in", "1977", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035920", "name": "C0035920#ent", "pos": [4, 5]}}
{"token": ["Clinical", "symptoms", "C0002878#ent", "<e1>", "2", "to", "6", "days", "from", "the", "onset", "of", "C0035920#ent", "<e2>"], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035920", "name": "C0035920#ent", "pos": [12, 13]}}
{"token": ["The", "rank", "order", "of", "potency", "of", "the", "C0969589#ent", "<e1>", "on", "alpha", "1-adrenoceptors", "rat", "aorta", "and", "alpha", "2-adrenoceptors", "NA", "greater", "than", "C0068986#ent", "<e2>", "=", "m-synephrine", "greater", "than", "p-octopamine", "=", "p-synephrine", "."], "h": {"id": "C0969589", "name": "C0969589#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0068986", "name": "C0068986#ent", "pos": [20, 21]}}
{"token": ["C1833809#ent", "<e1>", "ADOA", ")", "is", "genetically", "heterogeneous", "with", "C1537677#ent", "<e2>", "on", "3q28", "being", "the", "most", "prevalently", "mutated", "gene"], "h": {"id": "C1833809", "name": "C1833809#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537677", "name": "C1537677#ent", "pos": [8, 9]}}
{"token": ["The", "great", "majority", "of", "men", "afflicted", "by", "C0030794#ent", "<e1>", "of", "additional", "C0030193#ent", "<e2>", "particularly", "back", "and", "joint", "pain", "and", "fatigue", "."], "h": {"id": "C0030794", "name": "C0030794#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [11, 12]}}
{"token": ["Evident", "C0026961#ent", "<e1>", "inequality", "developed", "in", "the", "cats", "with", "C1538440#ent", "<e2>", "lesions", "."], "h": {"id": "C0026961", "name": "C0026961#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [9, 10]}}
{"token": ["Lysophosphatidylcholine", "(", "lyso-PTC", ")", "is", "formed", "by", "C0031667#ent", "<e1>", "PLA2", ")", "from", "phosphatidylcholine", "(", "C1706229#ent", "<e2>", ")", ",", "that", "is", "produced", "through", "phosphatidylethanolamine", "(", "PTE", ")", "methylation", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706229", "name": "C1706229#ent", "pos": [14, 15]}}
{"token": ["The", "azafluoranthene", "alkaloid", "eupolauridine", "has", "previously", "been", "shown", "to", "have", "in", "vitro", "C0003308#ent", "<e1>", "selective", "inhibition", "of", "C1336767#ent", "<e2>", "The", "present", "study", "was", "undertaken", "to", "examine", "further", "its", "selectivity", "and", "mode", "of", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [17, 18]}}
{"token": ["Pathological", "processing", "of", "the", "amyloid", "precursor", "protein", "C1364818#ent", "<e1>", ")", "is", "assumed", "to", "be", "responsible", "for", "the", "amyloid", "deposits", "C0002395#ent", "<e2>", "but", "the", "physiological", "function", "this", "protein", "in", "the", "brain", "is", "still", "unclear", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}}
{"token": ["We", "propose", "that", "C1418659#ent", "<e1>", ",", "through", "its", "interaction", "with", "Shc", ",", "promotes", "C0282625#ent", "<e2>", "activation", "through", "the", "EGF", "receptor"], "h": {"id": "C1418659", "name": "C1418659#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [13, 14]}}
{"token": ["However", ",", "5HT", "is", "both", "anxiogenic", "and", "C0040616#ent", "<e1>", ",", "and", "while", "5HT", "C0242980#ent", "<e2>", "effective", "in", "treatment", ",", "the", "role", "of", "5HT", "in", "the", "development", "of", "PTSD", "remains", "uncertain", "."], "h": {"id": "C0040616", "name": "C0040616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242980", "name": "C0242980#ent", "pos": [13, 14]}}
{"token": ["A", "second", "metabolite", ",", "tentatively", "identified", "as", "pyridine-N-oxide", "C0771315#ent", "<e1>", "C0038761#ent", "<e2>", ",", "was", "also", "formed", "during", "incubation", "with", "C0771315#ent", "<e1>", "C0038761#ent", "<e2>", "."], "h": {"id": "C0038761", "name": "C0038761#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0771315", "name": "C0771315#ent", "pos": [8, 9]}}
{"token": ["This", "study", "describes", "the", "anti-nicotinic", "properties", "of", "the", "clinically", "used", "anticholinergic", "antiparkinson", "drugs", "benztropine", ",", "biperiden", ",", "caramiphen", ",", "C0015042#ent", "<e1>", ",", "procyclidine", "and", "C0003830#ent", "<e2>", "."], "h": {"id": "C0015042", "name": "C0015042#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0003830", "name": "C0003830#ent", "pos": [24, 25]}}
{"token": ["Methoctramine", ",", "C0015042#ent", "<e1>", ",", "benztropine", "and", "C0003830#ent", "<e2>", "enhanced", "significantly", "[(3)H]thymidine", "uptake", "at", "subtoxic", "concentrations", "."], "h": {"id": "C0015042", "name": "C0015042#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003830", "name": "C0003830#ent", "pos": [7, 8]}}
{"token": ["To", "study", "whether", "intravenous", "diltiazem", ",", "a", "calcium", "channel", "blocker", "prescribed", "for", "hypertension", "and", "stable", "angina", "is", "an", "inhibitor", "of", "the", "CYP3A", "C3540790#ent", "<e1>", "by", "using", "oral", "lovastatin", "an", "C0360714#ent", "<e2>", "as", "a", "substrate", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0360714", "name": "C0360714#ent", "pos": [29, 30]}}
{"token": ["All", "chiral", "neutral", "C1367701#ent", "<e1>", "were", "resolved", "on", "the", "C4283942#ent", "<e2>", "column", ",", "whereas", "on", "Chirobiotic", "V", "only", "basic", "C1367701#ent", "<e1>", "showed", "a", "split", "peak", "."], "h": {"id": "C1367701", "name": "C1367701#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4283942", "name": "C4283942#ent", "pos": [9, 10]}}
{"token": ["In", "three", "animals", ",", "microinjection", "of", "C0813872#ent", "<e1>", "induced", "a", "complete", "apneusis", "in", "the", "absence", "of", "C0032285#ent", "<e2>", "which", "there", "was", "no", "detectable", "recovery", "."], "h": {"id": "C0813872", "name": "C0813872#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [16, 17]}}
{"token": ["Binding", "of", "these", "ions", ",", "which", "is", "facilitated", "by", "hyperpolarization", ",", "causes", "channel", "blockade", "resulting", "in", "the", "observed", "voltage", "dependence", "C1416378#ent", "<e1>", "in", "physiological", "concentrations", "of", "Ca2", "+", "and", "C1333909#ent", "<e2>", "+", "."], "h": {"id": "C1416378", "name": "C1416378#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [29, 30]}}
{"token": ["As", "C1706508#ent", "<e1>", "is", "lost", "upon", "C0524889#ent", "<e2>", "TCR", ")", "engagement", "in", "vitro", "we", "hypothesize", "that", "TCR", "triggering", "is", "a", "prerequisite", "for", "homeostatically", "driven", "peripheral", "postthymic", "expansion", "of", "human", "naive", "RTEs", "."], "h": {"id": "C1706508", "name": "C1706508#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0524889", "name": "C0524889#ent", "pos": [6, 7]}}
{"token": ["C0009450#ent", "<e1>", "predominant", ",", "and", "diarrhoea", ",", "respiratory", "disease", "C0040247#ent", "<e2>", "were", "the", "most", "common", "diagnoses", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [9, 10]}}
{"token": ["The", "subjects", "studied", "did", "not", "appear", "to", "suffer", "excessive", "morbidity", "from", "C0009450#ent", "<e1>", "other", "than", "C0040247#ent", "<e2>", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", ",", "as", "early", "as", "6", "months", ",", "depletion", "of", "the", "C2981619#ent", "<e1>", "sufficient", "to", "cause", "mild", "sensorimotor", "dysfunctions", "spatial", "deficits", "but", "without", "overt", "signs", "C0030552#ent", "<e2>", "."], "h": {"id": "C2981619", "name": "C2981619#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [28, 29]}}
{"token": ["Bovine", "viral", "diarrhea", "BVD", ")", "C0042769#ent", "<e1>", "diagnosed", "in", "neonatal", "calves", "with", "C0014335#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [12, 13]}}
{"token": ["It", "is", "suggested", "that", "procedures", "for", "the", "diagnosis", "of", "C0042769#ent", "<e1>", "always", "be", "included", "in", "the", "diagnosis", "of", "neonatal", "C0014335#ent", "<e2>"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [19, 20]}}
{"token": ["Epstein-Barr", "virus", "EBV", ")", "infection", "in", "early", "childhood", "usually", "asymptomatic", "or", "associated", "with", "symptoms", "common", "to", "many", "other", "C0042769#ent", "<e1>", "such", "as", "pharyngitis", ",", "bronchitis", "or", "C0014335#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [26, 27]}}
{"token": ["Twenty-four", "patients", "received", "dapsone", "as", "a", "part", "of", "multi-drug", "therapy", "C0023343#ent", "<e1>", ";", "the", "other", "two", "patients", "received", "dapsone", "for", "lichen", "planus", "C0702166#ent", "<e2>"], "h": {"id": "C0023343", "name": "C0023343#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0702166", "name": "C0702166#ent", "pos": [22, 23]}}
{"token": ["36", ",", "1175", "-", "1180", ")", ",", "this", "strain", "releases", "comparable", "levels", "of", "C0064292#ent", "<e1>", "with", "lower", "levels", "of", "C0017976#ent", "<e2>", "in", "the", "culture", "medium", "0.3", "%", "of", "keratan", "sulfate"], "h": {"id": "C0064292", "name": "C0064292#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017976", "name": "C0017976#ent", "pos": [19, 20]}}
{"token": ["Enzymatic", "digestion", "of", "cell", "surface", "carbohydrates", "with", "sialidase", ",", "C0064292#ent", "<e1>", "or", "other", "C0017976#ent", "<e2>", "can", "also", "be", "performed", "."], "h": {"id": "C0064292", "name": "C0064292#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017976", "name": "C0017976#ent", "pos": [13, 14]}}
{"token": ["Preliminary", "RNAi", "experiments", "suggested", "that", "downregulation", "of", "C1417248#ent", "<e1>", "is", "correlated", "with", "apoptosis", "in", "C1706327#ent", "<e2>", "-", "10", "mosquito", "cells"], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706327", "name": "C1706327#ent", "pos": [14, 15]}}
{"token": ["Mutations", "of", "the", "aprataxin", "(", "APTX", ")", "gene", "cause", "early-onset", "ataxia", "with", "ocular", "motor", "apraxia", "hypoalbuminemia", "(", "C1859598#ent", "<e1>", ")", ",", "also", "called", "ataxia", "with", "C3489733#ent", "<e2>"], "h": {"id": "C1859598", "name": "C1859598#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C3489733", "name": "C3489733#ent", "pos": [25, 26]}}
{"token": ["Senataxin", "recently", "was", "identified", "as", "the", "mutated", "gene", "C1859598#ent", "<e1>", "which", "is", "characterized", "by", "ataxia", ",", "C3489733#ent", "<e2>", "and", "increased", "alpha-fetoprotein", "levels"], "h": {"id": "C1859598", "name": "C1859598#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C3489733", "name": "C3489733#ent", "pos": [16, 17]}}
{"token": ["We", "propose", "the", "name", "BEHAB", ",", "Brain", "Enriched", "C1415457#ent", "<e1>", "for", "this", "C0017337#ent", "<e2>", "."], "h": {"id": "C1415457", "name": "C1415457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["In", "the", "spring", "of", "2002", ",", "a", "national", "shortage", "of", "all", "C0038317#ent", "<e1>", "the", "authors", "to", "compare", "epidural", "methylprednisolone", "C0057476#ent", "<e2>", ")", "to", "a", "non", "depo", "of", "betamethasone", "in", "patients", "with", "low", "back", "pain"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0057476", "name": "C0057476#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "report", "that", "C1705326#ent", "<e1>", "is", "specifically", "acetylated", "by", "C1333336#ent", "<e2>", "in", "vitro"], "h": {"id": "C1705326", "name": "C1705326#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333336", "name": "C1333336#ent", "pos": [11, 12]}}
{"token": ["The", "peaks", "of", "LS", "were", "decreased", "during", "the", "excitation", "and", "under", "the", "action", "of", "C0029904#ent", "<e1>", "and", "increased", "under", "the", "action", "of", "C0014996#ent", "<e2>", "."], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014996", "name": "C0014996#ent", "pos": [22, 23]}}
{"token": ["Five", "antirheumatic", "agents", "auranofin", ",", "C0733383#ent", "<e1>", ",", "D-penicillamine", ",", "chloroquine", "and", "C0018033#ent", "<e2>", ",", "were", "tested", "and", "none", "inhibited", "the", "disease", "process"], "h": {"id": "C0733383", "name": "C0733383#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018033", "name": "C0018033#ent", "pos": [12, 13]}}
{"token": ["Low", "C0019114#ent", "<e1>", "content", "of", "the", "bone", "marrow", "consistent", "with", "C0162316#ent", "<e2>", "but", "normalization", "of", "Hb", "without", "iron", "suppletion", "would", "argue", "against", "a", "major", "role", "of", "C0162316#ent", "<e2>"], "h": {"id": "C0019114", "name": "C0019114#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [10, 11]}}
{"token": ["The", "complications", "of", "intravascular", "hemolysis", ":", "cholelithiasis", ",", "anemia", ",", "C0019114#ent", "<e1>", "of", "the", "kidneys", ",", "C0162316#ent", "<e2>", "."], "h": {"id": "C0019114", "name": "C0019114#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [16, 17]}}
{"token": ["In", "myotonic", "dystrophy", "both", "C1446659#ent", "<e1>", "tau", "h", "were", "larger", "than", "control", ";", "in", "recessive", "generalized", "myotonia", "C0238357#ent", "<e2>", "C1446659#ent", "<e1>", "tau", "h", "were", "smaller", "than", "control", "."], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0238357", "name": "C0238357#ent", "pos": [17, 18]}}
{"token": ["In", "myotonic", "dystrophy", "both", "tau", "m", "C1446659#ent", "<e1>", "h", "were", "larger", "than", "control", ";", "in", "recessive", "generalized", "myotonia", "C0238357#ent", "<e2>", "tau", "m", "C1446659#ent", "<e1>", "h", "were", "smaller", "than", "control", "."], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0238357", "name": "C0238357#ent", "pos": [18, 19]}}
{"token": ["These", "antibiotics", "are", "more", "effective", "than", "the", "aminoglycosides", "in", "C0023530#ent", "<e1>", "patients", ",", "who", "are", "especially", "susceptible", "to", "C0033817#ent", "<e2>"], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033817", "name": "C0033817#ent", "pos": [18, 19]}}
{"token": ["C0023530#ent", "<e1>", "occurred", "with", "the", "C0033817#ent", "<e2>", "Groups", "II", "III", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033817", "name": "C0033817#ent", "pos": [5, 6]}}
{"token": ["Precipitation", "of", "C2983393#ent", "<e1>", "or", "CFTR", "from", "transfected", "HEK293", "cells", "from", "the", "C0771711#ent", "<e2>", "and", "submandibular", "gland", "coimmunoprecipitated", "EBP50", "."], "h": {"id": "C2983393", "name": "C2983393#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [12, 13]}}
{"token": ["Whether", "an", "C3273872#ent", "<e1>", "susceptibility", "gene", "lies", "on", "C1327812#ent", "<e2>", "our", "population", "must", "be", "determined", "by", "further", "analyses", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1327812", "name": "C1327812#ent", "pos": [8, 9]}}
{"token": ["The", "present", "study", "evaluated", "the", "efficacy", "of", "25", "mg", "of", "C0072828#ent", "<e1>", ",", "a", "new", "C0005064#ent", "<e2>", "in", "a", "population", "of", "chronic", "insomniacs"], "h": {"id": "C0072828", "name": "C0072828#ent", "pos": [10, 11]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [15, 16]}}
{"token": ["The", "C1417500#ent", "<e1>", "+", "-ATPase", "activity", "of", "preparations", "of", "myosin", "treated", "with", "C1335499#ent", "<e2>", "was", "not", "activated", "by", "modified", "or", "unmodified", "actin", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335499", "name": "C1335499#ent", "pos": [12, 13]}}
{"token": ["Newly", "described", "antioxidant", "proteins", "a", "soluble", "C0027280#ent", "<e1>", "MdaB", ")", "and", "an", "iron", "sequestering", "protein", "C1417599#ent", "<e2>", ")", "that", "has", "dual", "roles", "-", "host", "inflammation", "stimulation", "and", "minimizing", "reactive", "oxygen", "species", "production", "within", "H.", "pylori"], "h": {"id": "C0027280", "name": "C0027280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417599", "name": "C1417599#ent", "pos": [15, 16]}}
{"token": ["One", "patient", ",", "who", "subsequently", "was", "found", "to", "have", "a", "basophil", "adenoma", "the", "C0032002#ent", "<e1>", ",", "developed", "C0011848#ent", "<e2>", "late", "pregnancy", "the", "C0011848#ent", "<e2>", "spontaneously", "after", "delivery", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0011848", "name": "C0011848#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "C0072074#ent", "<e1>", "induced", "rapid", "transient", "activation", "of", "protein", "kinase", "C", "and", "C0075193#ent", "<e2>", "and", "H-7", "reduced", "the", "profilin-induced", "activation", "of", "AP-1", ",", "suggesting", "protein", "kinase", "activation", "of", "AP-1", "."], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [13, 14]}}
{"token": ["In", "addition", "to", "these", "cytokine-induced", "proteins", "we", "have", "identified", "C1412709#ent", "<e1>", "an", "Mr-8000", "protein", "C0669365#ent", "<e2>", "secreted", "by", "synovial", "cells"], "h": {"id": "C1412709", "name": "C1412709#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}}
{"token": ["A", "child", "with", "C0017923#ent", "<e1>", "with", "myopathy", ",", "recurrent", "hypoglycemia", ",", "and", "C0015544#ent", "<e2>"], "h": {"id": "C0017923", "name": "C0017923#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0015544", "name": "C0015544#ent", "pos": [12, 13]}}
{"token": ["Those", "that", "were", "active", "without", "bioactivation", "were", "C0037549#ent", "<e1>", "niridazole", ",", "phosphoramide", "mustard", "acrolein", ",", "C0163054#ent", "<e2>", ",", "4-ketocyclophosphamide", ",", "ethanol", ",", "and", "acetaldehyde", "."], "h": {"id": "C0037549", "name": "C0037549#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0163054", "name": "C0163054#ent", "pos": [15, 16]}}
{"token": ["A", "6-year-old", "boy", "with", "C1275808#ent", "<e1>", "Ondine's", "curse", "presented", "with", "C0700200#ent", "<e2>", "."], "h": {"id": "C1275808", "name": "C1275808#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0700200", "name": "C0700200#ent", "pos": [10, 11]}}
{"token": ["C3889156#ent", "<e1>", "was", "transported", "to", "the", "C0702216#ent", "<e2>", "of", "medium-sized", "and", "large", "ventral", "pallidum", "neurons", ",", "which", "along", "with", "their", "long", ",", "large", "dendrites", "were", "contacted", "by", "many", "glutamate", "decarboxylase", "immunoreactive", "synaptic", "boutons"], "h": {"id": "C3889156", "name": "C3889156#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0702216", "name": "C0702216#ent", "pos": [6, 7]}}
{"token": ["Intra-axonal", "recording", "and", "labeling", "with", "C3889156#ent", "<e1>", "was", "performed", "to", "examine", "synaptic", "inputs", "around", "C0702216#ent", "<e2>", "of", "mesencephalic", "trigeminal", "neuron", "(", "Vme", ")", "innervating", "the", "masseter", "muscle-spindles", "on", "electron", "microscopy"], "h": {"id": "C3889156", "name": "C3889156#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0702216", "name": "C0702216#ent", "pos": [14, 15]}}
{"token": ["The", "inhibition", "of", "the", "phosphorylation", "of", "C0017916#ent", "<e1>", "glucose", "6-phosphate", "explain", "the", "reported", "decreased", "phosphorylation", "of", "C0017916#ent", "<e1>", "in", "muscle", "following", "insulin", "treatment", "which", "elevates", "intracellular", "levels", "of", "glucose", "6-phosphate"], "h": {"id": "C0017916", "name": "C0017916#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017916", "name": "C0017916#ent", "pos": [6, 7]}}
{"token": ["C0017916#ent", "<e1>", "compared", "with", "C0017916#ent", "<e1>", "from", "other", "sources", "on", "the", "basis", "of", "chemical", "and", "kinetic", "properties", "."], "h": {"id": "C0017916", "name": "C0017916#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017916", "name": "C0017916#ent", "pos": [0, 1]}}
{"token": ["2,4,5,2',4',5'-Hexachlorobiphenyl", "and", "2,4,5,2',4',5'-hexabromobiphenyl", "did", "not", "significantly", "inhibit", "C0017916#ent", "<e1>", "a.", "All", "of", "the", "compounds", "inhibited", "C0017916#ent", "<e1>", "a", "less", "than", "C0017916#ent", "<e1>", "except", "2',3',4',5,5'-pentachloro-2-biphenylol", ",", "which", "was", "equally", "effective", "on", "each", "enzyme", "."], "h": {"id": "C0017916", "name": "C0017916#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017916", "name": "C0017916#ent", "pos": [7, 8]}}
{"token": ["In", "the", "present", "study", ",", "three", "C1514550#ent", "<e1>", "phosphoproteins", "(", "referred", "to", "as", "pp45", ",", "C1424931#ent", "<e2>", ",", "and", "pp10", ")", "were", "detected", "in", "the", "lumen", "fluid", "male", "accessory", "glands"], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1424931", "name": "C1424931#ent", "pos": [15, 16]}}
{"token": ["To", "evaluate", "the", "effects", "of", "salbutamol", "and", "C0700580#ent", "<e1>", "the", "isolated", "hyperinflation", ",", "without", "C0001883#ent", "<e2>", "during", "asymptomatic", "periods", "in", "asthmatic", "children", ",", "31", "children", ",", "out", "of", "ca", "."], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [14, 15]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", ",", "on", "the", "basis", "of", "clinical", "scores", "to", "determine", "the", "effect", "of", "salbutamol", "and", "C0700580#ent", "<e1>", "the", "treatment", "of", "C0001883#ent", "<e2>", "infants", "."], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [26, 27]}}
{"token": ["A", "nuclear", "extract", "from", "adult", "C0669372#ent", "<e1>", "was", "used", "to", "direct", "in", "vitro", "transcription", "of", "the", "C1413869#ent", "<e2>", "and", "CYP2A2", "gene", "promoters", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413869", "name": "C1413869#ent", "pos": [16, 17]}}
{"token": ["Medullary", "cystic", "kidney", "disease", "type", "1", "C1868139#ent", "<e1>", ")", "is", "an", "autosomal", "dominant", "C0041349#ent", "<e2>", "causes", "renal", "salt", "wasting", "end-stage", "renal", "failure", "the", "fourth", "to", "seventh", "decade", "of", "life", "."], "h": {"id": "C1868139", "name": "C1868139#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0041349", "name": "C0041349#ent", "pos": [13, 14]}}
{"token": ["The", "C1704885#ent", "<e1>", "proto-oncogene", "encodes", "a", "receptor", "with", "tyrosine", "kinase", "activity", "C1704885#ent", "<e1>", ")", "that", "is", "involved", "in", "several", "neoplastic", "and", "C1335026#ent", "<e1>"], "h": {"id": "C1704885", "name": "C1704885#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335026", "name": "C1335026#ent", "pos": [21, 22]}}
{"token": ["Germline", "mutations", "C1704885#ent", "<e1>", "have", "also", "been", "associated", "with", "C1335026#ent", "<e2>", "the", "congenital", "colonic", "aganglionosis", "i.e.", "Hirschsprung's", "disease", "HSCR", ")", "."], "h": {"id": "C1704885", "name": "C1704885#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335026", "name": "C1335026#ent", "pos": [9, 10]}}
{"token": ["Acyclovir", "has", "been", "the", "mainstay", "for", "treating", "severe", "varicella-zoster", "virus", "infections", "however", ",", "newer", "antiviral", "agents", "including", "valacyclovir", "and", "C0209227#ent", "<e1>", ",", "have", "expanded", "therapeutic", "options", "for", "treating", "adults", "with", "C0019360#ent", "<e2>"], "h": {"id": "C0209227", "name": "C0209227#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0019360", "name": "C0019360#ent", "pos": [30, 31]}}
{"token": ["A", "previous", "study", "has", "shown", "that", "C3890397#ent", "<e1>", "phosphorylates", "and", "activates", "C0669365#ent", "<e2>", "NOS", ")", "."], "h": {"id": "C3890397", "name": "C3890397#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["Akt", "and", "C1415321#ent", "<e1>", "known", "to", "be", "downstream", "molecules", "of", "C0044602#ent", "<e2>", ",", "leading", "to", "the", "antiapoptotic", "effect"], "h": {"id": "C1415321", "name": "C1415321#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [10, 11]}}
{"token": ["Optic", "nerve", "diseases", "C0012634#ent", "<e1>", "of", "the", "higher", "C0155287#ent", "<e2>", "show", "normal", "multifocal", "ERGs", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0155287", "name": "C0155287#ent", "pos": [8, 9]}}
{"token": ["Other", "monoaminergic", "drugs", "tested", "in", "these", "two", "brain", "areas", "prazosin", ",", "yohimbine", ",", "amphetamine", ",", "C0037239#ent", "<e1>", "SCH", "23390", "had", "no", "effects", "C0007384#ent", "<e2>", "."], "h": {"id": "C0037239", "name": "C0037239#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007384", "name": "C0007384#ent", "pos": [22, 23]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "investigate", "whether", "the", "relatively", "selective", ",", "C0669368#ent", "<e1>", "NOS", ")", "inhibitor", ",", "C0214185#ent", "<e2>", "(", "7-NI", ")", ",", "protects", "against", "METH-induced", "neurotoxicity", "."], "h": {"id": "C0669368", "name": "C0669368#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0214185", "name": "C0214185#ent", "pos": [18, 19]}}
{"token": ["Using", "systemic", "bromodeoxyuridine", "BrdU", ")", "to", "label", "dividing", "cells", ",", "we", "found", "that", "injection", "of", "the", "C0669368#ent", "<e1>", "nNOS", ")", "inhibitor", "C0214185#ent", "<e2>", "(", "50", "mg/kg", "i.p", ".", ")"], "h": {"id": "C0669368", "name": "C0669368#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0214185", "name": "C0214185#ent", "pos": [21, 22]}}
{"token": ["C0221032#ent", "<e1>", "the", "Seip-Berardinelli", "type", "is", "a", "C0039082#ent", "<e2>", "associated", "with", "insulin", "resistance", "recessive", "inheritance", "."], "h": {"id": "C0221032", "name": "C0221032#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [7, 8]}}
{"token": ["In", "vivo", "glibenclamide", "and", "C0061323#ent", "<e1>", "decrease", ",", "while", "gliclazide", "and", "C0724709#ent", "<e2>", "increase", ",", "the", "amount", "of", "strophanthidin-", "and", "ischaemia-induced", "ventricular", "ectopic", "beats", "and", "the", "duration", "of", "ventricular", "fibrillation"], "h": {"id": "C0061323", "name": "C0061323#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "neutral", "sphingomyelinase/ceramide", "pathway", "is", "required", "but", "may", "not", "be", "sufficient", "for", "iNOS", "expression", "induced", "by", "C0812246#ent", "<e1>", "and", "the", "combination", "of", "C0812246#ent", "<e1>", "and", "C1705543#ent", "<e1>", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [28, 29]}}
{"token": ["The", "infections", "included", "sinusitis", ",", "otitis", "media", "C0031085#ent", "<e1>", "Ludwig's", "angina", "parotitis", ",", "and", "C0264263#ent", "<e2>"], "h": {"id": "C0031085", "name": "C0031085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0264263", "name": "C0264263#ent", "pos": [14, 15]}}
{"token": ["Retroconversion", "reactions", "the", "higher", "C4277608#ent", "<e1>", ",", "especially", "of", "22", "C0524928#ent", "<e2>", "back", "again", "to", "lower", "C4277608#ent", "<e1>", "avoiding", "beta", "oxidation"], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [10, 11]}}
{"token": ["In", "some", "occupations", "the", "regulations", "concern", "also", "the", "C0034951#ent", "<e1>", "the", "eyes", "and", "possible", "C0015397#ent", "<e2>"], "h": {"id": "C0034951", "name": "C0034951#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [14, 15]}}
{"token": ["The", "C1741214#ent", "<e1>", "(", "FK506-binding", "protein", "gene", ",", "SERT", "(", "serotonin", "transporter", "gene", "and", "COMT", "(", "C0007407#ent", "<e2>", "mRNA", "expressions", "in", "the", "leukocytes", "were", "determined", "with", "hormonal", "data"], "h": {"id": "C1741214", "name": "C1741214#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007407", "name": "C0007407#ent", "pos": [16, 17]}}
{"token": ["The", "example", "of", "age-related", "sensitivity", "to", "organophosphate-induced", "delayed", "polyneuropathy", "is", "illustrated", "together", "with", "that", "of", "the", "promotion", "of", "C0270921#ent", "<e1>", "by", "certain", "C0596537#ent", "<e2>", "which", "also", "seem", "modulated", "according", "to", "age", "."], "h": {"id": "C0270921", "name": "C0270921#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0596537", "name": "C0596537#ent", "pos": [22, 23]}}
{"token": ["No", "significant", "in", "C1337111#ent", "<e1>", "mRNA", "level", "in", "either", "C1428707#ent", "<e2>", "were", "found", "following", "single", "administration", "of", "amphetamine", "."], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428707", "name": "C1428707#ent", "pos": [9, 10]}}
{"token": ["The", "ethanol", "plus", "Jo2", "treatment", "increased", "activity", "and", "content", "of", "C3887686#ent", "<e1>", ",", "iNOS", "content", "and", "C1710304#ent", "<e2>", "levels", ";", "these", "increases", "were", "blunted", "by", "SAM", "."], "h": {"id": "C3887686", "name": "C3887686#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "we", "report", "that", "human", "C1421563#ent", "<e1>", "directly", "phosphorylated", "by", "C4084905#ent", "<e2>", "both", "in", "vitro", "in", "vivo"], "h": {"id": "C1421563", "name": "C1421563#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [12, 13]}}
{"token": ["Malignant", "Melanoma", "of", "Soft", "Parts", "MMSP", ")", "is", "associated", "with", "C1852404#ent", "<e1>", "fusion", "protein", "arises", "due", "to", "chromosomal", "fusion", "the", "Ewings", "Sarcoma", "oncogene", "C0808901#ent", "<e2>", ")", "and", "the", "cellular", "transcription", "factor", "ATF1", "."], "h": {"id": "C1852404", "name": "C1852404#ent", "pos": [10, 11]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [23, 24]}}
{"token": ["Administration", "of", "either", "OKY-046", "or", "C1419071#ent", "<e1>", "PGI2", ")", "markedly", "enhanced", "C3642267#ent", "<e2>", ",", "in", "association", "with", "an", "increase", "in", "ETVI", "."], "h": {"id": "C1419071", "name": "C1419071#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3642267", "name": "C3642267#ent", "pos": [11, 12]}}
{"token": ["These", "two", "lines", "of", "evidence", "indicate", "that", "the", "C0032089#ent", "<e1>", "here", "is", "a", "functional", "equivalent", "of", "yeast", "C1425328#ent", "<e2>", "and", "might", "serve", "as", "a", "Cu", "delivery", "protein", "for", "the", "plant", "mitochondria", "."], "h": {"id": "C0032089", "name": "C0032089#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425328", "name": "C1425328#ent", "pos": [17, 18]}}
{"token": ["The", "clinical", "and", "the", "laboratory", "studies", "that", "latent", "C0040560#ent", "<e1>", "no", "marked", "effect", "on", "the", "progression", "of", "the", "C0008679#ent", "<e2>"], "h": {"id": "C0040560", "name": "C0040560#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [18, 19]}}
{"token": ["We", "present", "3", "cases", "of", "C1417245#ent", "<e1>", ",", "anti-neutrophil", "cytoplasmic", "antibody", "rapidly", "progressive", "C0017658#ent", "<e2>", "developed", "during", "the", "treatment", "with", "D-penicillamine", "(", "D-PC", ")", "for", "rheumatoid", "arthritis"], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [13, 14]}}
{"token": ["Autoantibodies", "such", "as", "anti-DNA", "and", "C1417245#ent", "<e1>", "(", "MPO", ")", "antibodies", "have", "been", "shown", "to", "cause", "C0017658#ent", "<e2>", "in", "experimental", "animal", "models"], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [16, 17]}}
{"token": ["To", "examine", "the", "relationship", "between", "aPC", "resistance", "and", "the", "development", "of", "pulmonary", "fibrosis", "C0032285#ent", "<e1>", "induced", "by", "bleomycin", "in", "mice", "carrying", "the", "C2984172#ent", "<e2>", "mutation", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2984172", "name": "C2984172#ent", "pos": [22, 23]}}
{"token": ["C0282527#ent", "<e1>", "neonatal", "adrenoleukodystrophy", "show", "typical", "clinical", "disorders", "liver", "damage", "to", "C0023890#ent", "<e2>", "."], "h": {"id": "C0282527", "name": "C0282527#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [11, 12]}}
{"token": ["The", "purpose", "of", "this", "study", "is", "to", "explain", "the", "protective", "effects", "neostigmine", "against", "C0052451#ent", "<e1>", "toxicity", "by", "suppressing", "C1176140#ent", "<e2>", "and", "hence", "decreasing", "formation", "of", "toxic", "metabolite", "C0052451#ent", "<e1>", "by", "neostigmine", "."], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0052451", "name": "C0052451#ent", "pos": [13, 14]}}
{"token": ["There", "are", "two", "major", "soluble", "elastin", "molecules", "these", "cultures", ",", "one", "of", "77", "kDa", "(", "C0651277#ent", "<e1>", ")", "and", "the", "other", "of", "71", "kDa", "(", "C0013765#ent", "<e2>", ")", "."], "h": {"id": "C0651277", "name": "C0651277#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [25, 26]}}
{"token": ["The", "most", "common", "C0442893#ent", "<e1>", "recurs", "is", "C1442864#ent", "<e2>"], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [7, 8]}}
{"token": ["We", "conclude", "that", "C3810598#ent", "<e1>", "in", "patients", "with", "C0403414#ent", "<e2>", "multiple", "causes", "."], "h": {"id": "C3810598", "name": "C3810598#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0403414", "name": "C0403414#ent", "pos": [8, 9]}}
{"token": ["We", "then", "examined", "the", "neutrophil", "migration", "the", "intestine", "and", "the", "effect", "of", "C1848296#ent", "<e1>", "on", "this", "migration", "by", "C1417245#ent", "<e2>"], "h": {"id": "C1848296", "name": "C1848296#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417245", "name": "C1417245#ent", "pos": [18, 19]}}
{"token": ["C3540800#ent", "<e1>", "acts", "as", "a", "competitive", "inhibitor", "of", "C0031653#ent", "<e2>", "activity", "by", "competing", "with", "magnesium", ",", "a", "cofactor", "of", "the", "enzyme", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031653", "name": "C0031653#ent", "pos": [8, 9]}}
{"token": ["In", "the", "years", "following", "its", "discovery", ",", "H.", "pylori", "infection", "humans", "has", "been", "shown", "to", "be", "associated", "with", "C0017152#ent", "<e1>", ",", "peptic", "ulcer", "disease", "and", "gastric", "carcinoma", "as", "well", "as", "other", ",", "C0017178#ent", "<e2>"], "h": {"id": "C0017152", "name": "C0017152#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [32, 33]}}
{"token": ["Reduced", "bone", "mass", "be", "postmenopausal", "or", "related", "to", "C0025322#ent", "<e1>", "type", "I", "osteoporosis", ",", "it", "may", "be", "age-related", "(", "C0029458#ent", "<e2>", ",", "or", "it", "may", "result", "from", "several", "other", "etiologic", "factors", "secondary", "osteoporosis", "."], "h": {"id": "C0025322", "name": "C0025322#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [19, 20]}}
{"token": ["The", "two", "C1417679#ent", "<e1>", "represent", "the", "corresponding", "canine", "orthologs", "of", "human", "aminomethyltransferase", "C0063517#ent", "<e2>", ")", "and", "the", "human", "T-cell", "leukemia", "associated", "(", "TCTA", ")", "gene", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0063517", "name": "C0063517#ent", "pos": [12, 13]}}
{"token": ["C0079594#ent", "<e1>", "(", "a", "stable", "PGI2", "C2987634#ent", "<e2>", ")", "."], "h": {"id": "C0079594", "name": "C0079594#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}}
{"token": ["Presence", "and", "localization", "of", "the", "prostacyclin", "receptor", "the", "rat", "brain", "and", "spinal", "cord", "examined", "by", "in", "vitro", "autoradiography", "C0079594#ent", "<e1>", ",", "a", "highly", "specific", "and", "stable", "C2987634#ent", "<e2>", "for", "this", "receptor", "."], "h": {"id": "C0079594", "name": "C0079594#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [26, 27]}}
{"token": ["C0700606#ent", "<e1>", "has", "been", "studied", "and", "applied", "to", "C0020538#ent", "<e2>", "tachycardia", "during", "open", "heart", "surgery"], "h": {"id": "C0700606", "name": "C0700606#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [8, 9]}}
{"token": ["The", "sequencing", "of", "the", "human", "genome", "has", "opened", "the", "way", "for", "using", "bioinformatics", "to", "identify", "sets", "of", "C1417679#ent", "<e1>", "controlled", "by", "specific", "C1335826#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1335826", "name": "C1335826#ent", "pos": [22, 23]}}
{"token": ["C0020676#ent", "<e1>", "is", "a", "manifestation", "of", "multi-hormonal", "resistance", "in", "pseudohypoparathyroidism", "type", "Ia", "C3494506#ent", "<e2>", "Ia", ")", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C3494506", "name": "C3494506#ent", "pos": [12, 13]}}
{"token": ["By", "increasing", "antiapoptotic", "proteins", "the", "C1332391#ent", "<e1>", "NMDA", "receptor", "activation", "may", "also", "promote", "C1420257#ent", "<e2>", "preventing", "apoptosis", "."], "h": {"id": "C1332391", "name": "C1332391#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "severe", "C0014061#ent", "<e1>", "TBE", ")", "in", "a", "patient", "who", "had", "previously", "experienced", "C0043124#ent", "<e2>", "another", "flavivirus", "infection", "endemic", "in", "Hungary", "."], "h": {"id": "C0014061", "name": "C0014061#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0043124", "name": "C0043124#ent", "pos": [14, 15]}}
{"token": ["However", ",", "the", "inactivated", "C1706112#ent", "<e1>", "in", "the", "C0333980#ent", "<e2>", "that", "in", "the", "hepatocellular", "carcinoma", "not", "identical", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0333980", "name": "C0333980#ent", "pos": [8, 9]}}
{"token": ["C0014070#ent", "<e1>", "a", "misnomer", "that", "describes", "epidemics", "of", "probable", "C0221423#ent", "<e2>", "bears", "no", "definite", "relationship", "to", "chronic", "fatigue", "myalgia", "syndrome"], "h": {"id": "C0014070", "name": "C0014070#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [9, 10]}}
{"token": ["The", "interaction", "between", "C0031935#ent", "<e1>", "(", "a", "selective", "C3850099#ent", "<e2>", "and", "d-amphetamine", "on", "the", "operant", "performance", "of", "rats", "maintained", "under", "variable-interval", "schedules", "of", "positive", "reinforcement", "examined", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [8, 9]}}
{"token": ["Transient", "expression", "of", "pR33", "in", "COS-7", "cells", "results", "in", "constitutive", "activation", "of", "phospholipase", "C", "C2987155#ent", "<e1>", ")", "due", "to", "coupling", "to", "C0086376#ent", "<e2>", "the", "G(q)", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}}
{"token": ["Hepatic", "hydrothorax", "C4085201#ent", "<e1>", ")", "is", "an", "uncommon", "manifestation", "of", "C0023890#ent", "<e2>", "with", "ascites", "."], "h": {"id": "C4085201", "name": "C4085201#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [10, 11]}}
{"token": ["In", "human", "beings", "the", "defensins", ",", "cathelicidins", "and", "C0360714#ent", "<e1>", "are", "the", "principal", "C1136254#ent", "<e2>", "peptides", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "a", "distinct", "elevation", "in", "the", "measured", "cellular", "activities", "C1705066#ent", "<e1>", "and", "-3", "but", "not", "of", "caspase-8", "points", "to", "the", "C0910167#ent", "<e2>", "the", "predominant", "apoptotic", "pathway", "the", "degeneration", "of", "dopaminergic", "neurons", "MN9D", "cells", "."], "h": {"id": "C1705066", "name": "C1705066#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0910167", "name": "C0910167#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggested", "that", "C1176140#ent", "<e1>", "mainly", "catalyzed", "C1704665#ent", "<e2>", "to", "FBPA", "in", "rats", ",", "and", "the", "modification", "of", "this", "enzyme", "activity", "affect", "the", "pharmacokinetics", "of", "C1704665#ent", "<e2>", "."], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [8, 9]}}
{"token": ["We", "treated", "14", "patients", "(", "9", "with", "chronic", "LE", "5", "with", "subacute", "cutaneous", "LE", "who", "had", "poorly", "responded", "to", "chloroquine", "or", "C0596007#ent", "<e1>", "with", "an", "association", "of", "chloroquine", "and", "C0282331#ent", "<e2>", "."], "h": {"id": "C0596007", "name": "C0596007#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0282331", "name": "C0282331#ent", "pos": [29, 30]}}
{"token": ["Most", "widely", "used", "antimalarials", "are", "chloroquine", ",", "C0596007#ent", "<e1>", ",", "and", "less", "commonly", "C0282331#ent", "<e2>", "."], "h": {"id": "C0596007", "name": "C0596007#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0282331", "name": "C0282331#ent", "pos": [13, 14]}}
{"token": ["C0748397#ent", "<e1>", "a", "special", "case", "which", "associates", "systemic", "sclerosis", "C0008312#ent", "<e2>"], "h": {"id": "C0748397", "name": "C0748397#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "extrapolation", "of", "obtained", "results", "to", "clinical", "practice", "indicate", "that", "patients", "with", "complex", "partial", "seizures", "be", "safely", "co-medicated", "with", "C0023521#ent", "<e1>", "or", "SPIR", "without", "the", "risk", "of", "worsening", "of", "C0036572#ent", "<e2>"], "h": {"id": "C0023521", "name": "C0023521#ent", "pos": [20, 21]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [30, 31]}}
{"token": ["In", "contrast", "to", "reports", "in", "oriental", "populations", "our", "results", "do", "not", "support", "a", "major", "role", "of", "C1412481#ent", "<e1>", ",", "PARKIN", "and", "C1135159#ent", "<e2>", "polymorphisms", "in", "PD", "susceptibility", "in", "the", "Finnish", "population"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1135159", "name": "C1135159#ent", "pos": [21, 22]}}
{"token": ["It", "has", "been", "suggested", "that", "polymorphisms", "in", "apolipoprotein", "E", "C1412481#ent", "<e1>", ")", ",", "PARKIN", "and", "C1135159#ent", "<e2>", "(", "COMT", ")", "genes", "might", "increase", "the", "risk", "of", "PD", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1135159", "name": "C1135159#ent", "pos": [15, 16]}}
{"token": ["Deposits", "of", "C1861305#ent", "<e1>", "and", "C1336937#ent", "<e2>", "showed", "a", "focal", "distribution", "leaving", "many", "portal", "tracts", "of", "C1861305#ent", "<e1>", "."], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1861305", "name": "C1861305#ent", "pos": [2, 3]}}
{"token": ["Some", "evidence", "has", "been", "presented", "that", "C1336937#ent", "<e1>", "inhibits", "also", "membrane-associated", "pore", "formation", "inhibiting", "C9", "polymerization", "the", "terminal", "complement", "complex", "C1861305#ent", "<e2>", ")", "."], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1861305", "name": "C1861305#ent", "pos": [20, 21]}}
{"token": ["However", ",", "it", "remains", "unclear", "whether", "this", "PKCbeta-mediated", "phosphorylation", "accounts", "fully", "for", "the", "activation", "status", "CARMA1", ",", "because", "involvement", "of", "other", "C0031727#ent", "<e1>", ",", "such", "as", "C3711686#ent", "<e2>", "has", "also", "been", "suggested", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3711686", "name": "C3711686#ent", "pos": [26, 27]}}
{"token": ["SK&F", "81297", "induced", "marked", "hypermotility", "which", "was", "partially", "inhibited", "by", "C0215266#ent", "<e1>", "SK&F", "75670", "was", "completely", "blocked", "by", "the", "D1", "antagonist", "C0080138#ent", "<e2>"], "h": {"id": "C0215266", "name": "C0215266#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080138", "name": "C0080138#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "conformational", "changes", "of", "the", "beta", "heavy", "chain", "and", "the", "interaction", "between", "C1332790#ent", "<e1>", "IC1", "changes", "during", "C2744579#ent", "<e2>", "hydrolysis", "."], "h": {"id": "C1332790", "name": "C1332790#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [20, 21]}}
{"token": ["Species", "differences", "of", "C1366496#ent", "<e1>", "were", "recognized", "by", "MAb3", "-", "C1121761#ent", "<e2>", "on", "the", "basis", "of", "differential", "immunosuppression", "of", "aromatase", "activity"], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1121761", "name": "C1121761#ent", "pos": [10, 11]}}
{"token": ["The", "range", "of", "potential", "infections", "for", "which", "these", "C0035064#ent", "<e1>", "may", "have", "clinical", "utility", "includes", "C0085293#ent", "<e2>", "Kaposi's", "sarcoma"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085293", "name": "C0085293#ent", "pos": [15, 16]}}
{"token": ["It", "is", "a", "feature", "of", "the", "C0014130#ent", "<e1>", "are", "often", "associated", "with", "epilepsy", ":", "C0271623#ent", "<e2>", "hypergonadotropic", "hypogonadism", "and", "functional", "hyperprolactinemia", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [14, 15]}}
{"token": ["We", "also", "identified", "this", "C0032999#ent", "<e1>", "be", "the", "C0127082#ent", "<e2>", "MMP-1", ")", ",", "and", "showed", "that", "this", "enzyme", "had", "a", "significant", "role", "in", "modulating", "IGF", "action", "in", "ASM", "cells"], "h": {"id": "C0032999", "name": "C0032999#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggested", "that", "skeletal", "muscle", "have", "the", "potential", "to", "perform", "post-translational", "acylation", "C1825346#ent", "<e1>", ",", "and", "short", "ghrelin", "variant", "might", "have", "the", "biological", "effects", "C1883559#ent", "<e2>", "C1825346#ent", "<e1>", "."], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [25, 26]}}
{"token": ["Of", "the", "C0018296#ent", "<e1>", "involved", "in", "the", "regulation", "of", "the", "fusion", "machinery", ",", "C3816215#ent", "<e2>", "Mfn2", ")", "plays", "an", "important", "role", "in", "the", "nervous", "system", "point", "mutations", "of", "this", "isoform", "are", "associated", "with", "Charcot", "Marie", "Tooth", "neuropathy"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3816215", "name": "C3816215#ent", "pos": [13, 14]}}
{"token": ["Large", "C0018296#ent", "<e1>", "in", "the", "mitochondrial", "outer", "membrane", "termed", "Fzo", "or", "C3816215#ent", "<e2>", ",", "have", "been", "identified", "as", "key", "components", "of", "the", "mitochondrial", "fusion", "machinery", "in", "yeast", ",", "flies", "and", "mammalian", "cells"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3816215", "name": "C3816215#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "we", "tested", "the", "hypothesis", "that", "C1366463#ent", "<e1>", "mRNA", "and", "protein", "expressions", "modulated", "by", "C2936886#ent", "<e2>", "(", "Ca(2+)", "in", "primary", "human", "skeletal", "myocytes", "."], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "we", "test", "whether", "C1418825#ent", "<e1>", "is", "required", "for", "sensitization", "of", "C1707621#ent", "<e2>", "responses", "in", "a", "PD", "model", "."], "h": {"id": "C1418825", "name": "C1418825#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1707621", "name": "C1707621#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "these", "C0010536#ent", "<e1>", "was", "inhibited", "by", "the", "antioxidant", "N-acetyl-L-cysteine", "C1622105#ent", "<e2>", ")", "and", "by", "the", "PKCbeta", "inhibitor", "LY379196", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [11, 12]}}
{"token": ["In", "previous", "studies", "inhibition", "or", "activation", "of", "C0010536#ent", "<e1>", "PKA", ")", "blocked", "C1622105#ent", "<e2>", "amphetamine-produced", "CPP", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [12, 13]}}
{"token": ["Although", "in", "both", "syndromes", "this", "defect", "is", "based", "on", "mutations", "in", "the", "same", "C0079429#ent", "<e1>", ",", "XPD", ",", "only", "XP-D", ",", "not", "C2983123#ent", "<e2>", ",", "individuals", "have", "an", "increased", "risk", "of", "skin", "cancer"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2983123", "name": "C2983123#ent", "pos": [22, 23]}}
{"token": ["The", "activity", "of", "octreotide", "acetate", "a", "total", "nutrient", "admixture", "(", "C1539092#ent", "<e1>", ")", "and", "the", "effect", "of", "the", "C1254351#ent", "<e2>", "on", "the", "stability", "of", "lipid", "emulsion", "the", "C1539092#ent", "<e1>", "were", "studied", "."], "h": {"id": "C1539092", "name": "C1539092#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["C0077768#ent", "<e1>", "is", "a", "potent", "C0028841#ent", "<e2>"], "h": {"id": "C0077768", "name": "C0077768#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028841", "name": "C0028841#ent", "pos": [5, 6]}}
{"token": ["For", "soft", "tissue", "infections", "to", "molds", "characterized", "by", "thin", ",", "septate", "hyphae", "branching", "at", "acute", "angles", "C0393080#ent", "<e1>", "should", "be", "considered", "a", "first-line", "C0003308#ent", "<e2>"], "h": {"id": "C0393080", "name": "C0393080#ent", "pos": [16, 17]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [23, 24]}}
{"token": ["C0029882#ent", "<e1>", "effusion", "(", "OME", ")", "is", "a", "C1290884#ent", "<e2>", "the", "tubotympanum", "."], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [8, 9]}}
{"token": ["The", "association", "of", "macular", "rash", "C0033775#ent", "<e1>", ",", "low", "platelet", "count", "leukopenia", "was", "statistically", "predictive", "C0011311#ent", "<e2>", "but", "not", "clinically", ",", "since", "these", "four", "signs", "occur", "in", "many", "other", "viral", "infections"], "h": {"id": "C0033775", "name": "C0033775#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011311", "name": "C0011311#ent", "pos": [15, 16]}}
{"token": ["FT3", "values", "measured", "in", "30", "normal", "adults", "from", "1.77", "to", "4.77", "ng/L.", "Comparison", "with", "ratios", "of", "total", "T3", "to", "C1420598#ent", "<e1>", "good", "agreement", "in", "normal", "subjects", "pregnant", "women", "and", "hypothyroid", "and", "C0020550#ent", "<e2>", "patients", "."], "h": {"id": "C1420598", "name": "C1420598#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [31, 32]}}
{"token": ["The", "complications", "of", "C0235574#ent", "<e1>", ":", "cholelithiasis", ",", "anemia", ",", "C0019114#ent", "<e2>", "of", "the", "kidneys", ",", "sideropenia", "."], "h": {"id": "C0235574", "name": "C0235574#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019114", "name": "C0019114#ent", "pos": [10, 11]}}
{"token": ["The", "majority", "of", "PPI", "nonresponders", "had", "a", "clinical", "diagnosis", "C0017168#ent", "<e1>", "and", "were", "receiving", ">", "/=40", "mg", "of", "C0378482#ent", "<e2>", "daily", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0378482", "name": "C0378482#ent", "pos": [18, 19]}}
{"token": ["Among", "the", "low-hsCRP", "subjects", ",", "the", "C1705581#ent", "<e1>", "expression", "levels", "were", "higher", "in", "C1956346#ent", "<e2>", "patients", "than", "in", "non-CAD", "subjects", "(", "P", "<", "0.05", ",", "after", "being", "adjusted", "for", "other", "risk", "factors", "."], "h": {"id": "C1705581", "name": "C1705581#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [13, 14]}}
{"token": ["A", "polymorphism", "of", "the", "C1705581#ent", "<e1>", "Asp299Gly", ",", "is", "associated", "with", "increased", "risk", "for", "C1956346#ent", "<e2>", "Caucasian", "populations", "."], "h": {"id": "C1705581", "name": "C1705581#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["In", "this", "article", "we", "reviewed", "this", "new", "C0270697#ent", "<e1>", "entity", "(", "idiopathic", "form", "using", "the", "C0037088#ent", "<e2>", "25", "reported", "patients", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037088", "name": "C0037088#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "viral", "oncogene", "homolog", "B1", "C0812241#ent", "<e1>", ")", "mutation", "frequency", "in", "serrated", "colorectal", "adenocarcinoma", "C0018790#ent", "<e2>", ")", ",", "and", "to", "verify", "the", "existence", "of", "a", "new", "serrated", "pathway", "."], "h": {"id": "C0812241", "name": "C0812241#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018790", "name": "C0018790#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "show", "that", "KIAA0793", ",", "containing", "substantial", "sequence", "homology", "with", "the", "catalytic", "Dbl", "homology", "domain", "of", "the", "C0175701#ent", "<e1>", "FGD1", ")", ",", "is", "a", "specific", "GEF", "for", "C1366537#ent", "<e2>", "."], "h": {"id": "C0175701", "name": "C0175701#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1366537", "name": "C1366537#ent", "pos": [28, 29]}}
{"token": ["In", "this", "report", ",", "changes", "in", "the", "expression", "of", "three", "other", "genes", "in", "response", "to", "folic", "acid", "injury", "been", "investigated", ":", "C0029282#ent", "<e1>", "epidermal", "growth", "factor", "EGF", ")", ",", "and", "sulfated", "glycoprotein-2", "C1413514#ent", "<e2>", ")", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1413514", "name": "C1413514#ent", "pos": [32, 33]}}
{"token": ["Cryopreserved", "tissues", "eyes", "of", "normal", "subjects", "subjects", "with", "C1332628#ent", "<e1>", "or", "proliferative", "C0339491#ent", "<e2>", "used", "with", "streptavidin", "peroxidase", "immunohistochemistry", "."], "h": {"id": "C1332628", "name": "C1332628#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0339491", "name": "C0339491#ent", "pos": [12, 13]}}
{"token": ["Use", "of", "C0132326#ent", "<e1>", "was", "not", "associated", "with", "significantly", "increased", "risk", "of", "clinical", "hepatotoxic", "events", "including", "C0085605#ent", "<e2>", "liver", "related", "death", "compared", "to", "therapy", "with", "other", "antiretroviral", "drugs"], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [16, 17]}}
{"token": ["In", "vitro", "studies", "with", "purified", "C3810600#ent", "<e1>", "fusion", "proteins", "purified", "kinases", "that", "C3810600#ent", "<e1>", "was", "robustly", "phosphorylated", "by", "the", "C0243045#ent", "<e1>"], "h": {"id": "C3810600", "name": "C3810600#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [19, 20]}}
{"token": ["However", ",", "the", "C3658273#ent", "<e1>", "3-ketoacyl-CoA", "thiolase", "activities", "of", "the", "C1969443#ent", "<e2>", "variably", "decreased", "in", "skin", "fibroblasts"], "h": {"id": "C3658273", "name": "C3658273#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1969443", "name": "C1969443#ent", "pos": [10, 11]}}
{"token": ["C3250443#ent", "<e1>", "(", "P", "=", "0.59", ")", "and", "C1419183#ent", "<e2>", "(", "P", "=", "0.64", ")", "also", "tended", "to", "fall", "with", "falling", "PAO2", "."], "h": {"id": "C3250443", "name": "C3250443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419183", "name": "C1419183#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "in", "response", "to", "tumor", "necrosis", "factor-alpha", "C0534519#ent", "<e1>", ",", "NADPH", "oxidase", "ROS", "within", "early", "endosomes", "and", "that", "C1456389#ent", "<e2>", "can", "not", "produce", "sufficient", "ROS", "for", "cell", "signaling", "the", "absence", "of", "ClC-3", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1456389", "name": "C1456389#ent", "pos": [20, 21]}}
{"token": ["Our", "data", "do", "not", "confirm", "the", "commonly", "regarded", "direct", "relationship", "between", "local", "C0002932#ent", "<e1>", "antifibrillatory", "activity", "of", "C0033216#ent", "<e2>", "."], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [17, 18]}}
{"token": ["Accurate", "carrier", "testing", "prenatal", "diagnosis", "C0013264#ent", "<e1>", "DMD", ")", "families", "is", "facilitated", "when", "an", "C0795887#ent", "<e2>", "found", "to", "be", "segregating", "within", "a", "family", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0795887", "name": "C0795887#ent", "pos": [14, 15]}}
{"token": ["The", "gene", "responsible", "for", "the", "C0013264#ent", "<e1>", "phenotype", "is", "located", "at", "C0795887#ent", "<e2>", "and", "its", "427", "kD", "protein", "product", "called", "dystrophin", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0795887", "name": "C0795887#ent", "pos": [11, 12]}}
{"token": ["At", "least", "two", "C1366566#ent", "<e1>", "CTACK", ")", ",", "three", "SLC", ",", "and", "four", "C1705072#ent", "<e2>", "genes", "or", "pseudogenes", "are", "present", "in", "some", "haplotypes", "."], "h": {"id": "C1366566", "name": "C1366566#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705072", "name": "C1705072#ent", "pos": [13, 14]}}
{"token": ["At", "least", "two", "cutaneous", "T", "cell-attracting", "chemokine", "C1366566#ent", "<e1>", ")", ",", "three", "SLC", ",", "and", "four", "C1705072#ent", "<e2>", "genes", "or", "pseudogenes", "are", "present", "in", "some", "haplotypes", "."], "h": {"id": "C1366566", "name": "C1366566#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705072", "name": "C1705072#ent", "pos": [16, 17]}}
{"token": ["i", ")", "Chimeric", "C0266427#ent", "<e1>", "were", "fused", "to", "the", "C1366498#ent", "<e2>", "cat", ")", "and", "tested", "for", "transient", "gene", "expression", "transfection", "into", "liver-derived", "cells", "or", "NIH", "3T3", "."], "h": {"id": "C0266427", "name": "C0266427#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366498", "name": "C1366498#ent", "pos": [9, 10]}}
{"token": ["Plasmids", "were", "constructed", "in", "which", "the", "deleted", "or", "full-length", "MMTV", "C0266427#ent", "<e1>", "were", "placed", "upstream", "of", "the", "C1366498#ent", "<e2>"], "h": {"id": "C0266427", "name": "C0266427#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366498", "name": "C1366498#ent", "pos": [17, 18]}}
{"token": ["Previous", "studies", "have", "reported", "that", "C2936485#ent", "<e1>", "reduce", "plasma", "glucose", "in", "situations", "of", "hyperglycaemia", "and", "C0011847#ent", "<e2>", "in", "rodents", "."], "h": {"id": "C2936485", "name": "C2936485#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [15, 16]}}
{"token": ["Effects", "of", "high", "Ca2+o", "and", "Gd3", "+", "were", "abolished", "by", "blockade", "of", "C0031667#ent", "<e1>", "PLA2", ")", "but", "not", "by", "inhibition", "of", "C0031671#ent", "<e2>", "PLC", ")", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [12, 13]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [21, 22]}}
{"token": ["ATP", "stimulates", "arachidonic", "acid", "release", "and", "prostaglandin", "biosynthesis", "most", "likely", "via", "phospholipase", "A2", "C0031667#ent", "<e1>", ")", "activation", ")", "and", "C0031671#ent", "<e2>", "PLC", ")", "activation", "in", "cultured", "rabbit", "coronary", "microvessel", "endothelial", "cells", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [19, 20]}}
{"token": ["Accumulation", "of", "[3H]adenine", "in", "the", "C3812173#ent", "<e1>", "in", "nuclear", "and", "cytoplasmic", "poly(A", ")", "of", "HeLa", "cells", "that", "the", "C1523975#ent", "<e2>", "along", "a", "curve", "similar", "to", "that", "of", "the", "C3812173#ent", "<e1>"], "h": {"id": "C1523975", "name": "C1523975#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3812173", "name": "C3812173#ent", "pos": [5, 6]}}
{"token": ["Indirect-acting", "genotoxins", "included", "hydroxyurea", "(", "HU", ")", ",", "a", "ribonucleotide", "reductase", "inhibitor", "taxol", "(", "C0246415#ent", "<e1>", ")", ",", "a", "microtubule", "inhibitor", "and", "etoposide", "(", "C0059874#ent", "<e2>", ")", ",", "a", "DNA", "topoisomerase", "II", "inhibitor"], "h": {"id": "C0246415", "name": "C0246415#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0059874", "name": "C0059874#ent", "pos": [24, 25]}}
{"token": ["Most", "of", "the", "mothers", "were", "less", "than", "30", "years", "of", "age", ",", "had", "singleton", "pregnancies", "and", "about", "two-thirds", "were", "complicated", "by", "placenta", "praevia", "C2314882#ent", "<e1>", "preeclampsia", ",", "and", "anaemia", "associated", "with", "hookworm", "C0030499#ent", "<e2>", "."], "h": {"id": "C2314882", "name": "C2314882#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [32, 33]}}
{"token": ["The", "carboxyl-terminal", "portion", "the", "conserved", "domain", "was", "expressed", "as", "a", "glutathione", "S-transferase", "fusion", "protein", "exhibited", "cAMP", "C1849508#ent", "<e1>", "activity", "which", "was", "inhibited", "by", "C0055728#ent", "<e2>", ",", "a", "specific", "cGI", "C1849508#ent", "<e1>", "inhibitor", "."], "h": {"id": "C0055728", "name": "C0055728#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1849508", "name": "C1849508#ent", "pos": [16, 17]}}
{"token": ["However", ",", "the", "quantitatively", "important", "male-specific", "P450", "2C11", "was", "down-regulated", "by", "C0008286#ent", "<e1>", "and", "concomitant", "induction", "of", "C0070319#ent", "<e2>", "associated", "7-pentylresorufin", "O-depentylase", "activity", "noted", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0070319", "name": "C0070319#ent", "pos": [17, 18]}}
{"token": ["Three", "serious", "cases", "of", "C0038218#ent", "<e1>", "severe", "hypercapnic", "acidosis", "to", "adequate", "conventional", "therapy", "treated", "by", "C0018549#ent", "<e2>", "."], "h": {"id": "C0038218", "name": "C0038218#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "role", "of", "C0034665#ent", "<e1>", "during", "MEL", "differentiation", "we", "constructed", "MEL", "transfectants", "capable", "to", "express", "or", "block", "C0034665#ent", "<e1>", "mRNA", "production", "C0907533#ent", "<e1>", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [23, 24]}}
{"token": ["Only", "gross", "morphologic", "brain", "defects", ",", "as", "visualized", "by", "computerized", "tomography", "caused", "manifest", "clinical", "signs", "brain", "dysfunction", "such", "as", "C0014544#ent", "<e1>", ",", "mental", "retardation", "paresis", ",", "and", "C0796110#ent", "<e2>"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0796110", "name": "C0796110#ent", "pos": [27, 28]}}
{"token": ["Using", "paraffin", "embedded", "tissues", "we", "performed", "the", "C0020498#ent", "<e1>", "and", "PCR", "on", "the", "cerebrum", ",", "lungs", ",", "C0023899#ent", "<e2>", ",", "spleen", ",", "bone", "marrow", "adrenal", "gland", "and", "kidneys", "."], "h": {"id": "C0020498", "name": "C0020498#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [17, 18]}}
{"token": ["Our", "aim", "was", "to", "study", "the", "relation", "between", "C0018520#ent", "<e1>", "halitophobia", "and", "oral", "hygiene", "C0017563#ent", "<e2>"], "h": {"id": "C0018520", "name": "C0018520#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [14, 15]}}
{"token": ["The", "management", "of", "C0018520#ent", "<e1>", "involves", "maintenance", "of", "plaque", "control", ",", "elimination", "of", "C0017563#ent", "<e2>", "cleaning", "the", "tongue", "on", "a", "routine", "basis", "."], "h": {"id": "C0018520", "name": "C0018520#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [13, 14]}}
{"token": ["Post", "mortem", "studies", "of", "the", "basal", "ganglia", "C1516876#ent", "<e1>", "modified", "mice", "lacking", "functional", "copies", "the", "C1707622#ent", "<e2>", "us", "to", "test", "these", "predictions", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1707622", "name": "C1707622#ent", "pos": [15, 16]}}
{"token": ["The", "objectives", "of", "the", "study", "were", "to", "determine", "clinical", "patterns", "C0011603#ent", "<e1>", "and", "its", "response", "to", "C0038317#ent", "<e2>", "with", "and", "without", "antibiotics", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [16, 17]}}
{"token": ["Subsequently", ",", "a", "severe", "C0011603#ent", "<e1>", "occurred", "that", "required", "hospitalization", "of", "one", "patient", "and", "intravenous", "administration", "C0038317#ent", "<e2>", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [16, 17]}}
{"token": ["The", "rps3-rpl16-rpl5-rps14", "region", "of", "B.", "napus", "mtDNA", "may", "function", "as", "a", "ribosomal", "operon", "similar", "to", "the", "C1419037#ent", "<e1>", "and", "SPC", "operons", "of", "Escherichia", "coli", "to", "the", "ribosomal", "protein", "operon", "the", "C1955992#ent", "<e2>", "Euglena", "gracilis"], "h": {"id": "C1419037", "name": "C1419037#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1955992", "name": "C1955992#ent", "pos": [30, 31]}}
{"token": ["Inhibition", "of", "the", "Src-family", "PTKs", ",", "C0812307#ent", "<e1>", ",", "and", "Src-family", "PTKs", "upstream", "signaling", "molecules", "the", "p38MAPK", "pathway", "by", "C1417819#ent", "<e2>", ",", "a", "specific", "Src-family", "kinase", "inhibitor", "resulted", "in", "the", "inhibition", "of", "p38MAPK", "and", "IL-10", "expression", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417819", "name": "C1417819#ent", "pos": [19, 20]}}
{"token": ["We", "have", "now", "examined", "the", "role", "of", "C0812312#ent", "<e1>", "in", "the", "regulation", "of", "the", "C1708431#ent", "<e2>", "expression", "by", "PKC", "and", "cAMP", "in", "THP-1", "cells", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1708431", "name": "C1708431#ent", "pos": [14, 15]}}
{"token": ["C3273858#ent", "<e1>", "far", "exceeds", "LPS", "as", "a", "C0085423#ent", "<e2>", "these", "findings", "therefore", "implicate", "C3273858#ent", "<e1>", "as", "an", "additional", "putative", "mediator", "of", "SIRS", "arising", "from", "gram-negative", "infection"], "h": {"id": "C3273858", "name": "C3273858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [7, 8]}}
{"token": ["Extubation", "was", "done", "as", "quickly", "as", "in", "NLA", ",", "after", "C0002575#ent", "<e1>", "infusion", "which", "was", "said", "to", "C0026056#ent", "<e2>"], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "RV39", "infection", "induced", "phosphorylation", "of", "C0752312#ent", "<e1>", "and", "transactivation", "of", "the", "C1705592#ent", "<e2>", "promoter", "AP-1", "site", ",", "which", "functions", "as", "a", "basal", "level", "enhancer", ",", "leading", "to", "enhanced", "TNF-alpha", "responses", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [13, 14]}}
{"token": ["C0812313#ent", "<e1>", "is", "a", "component", "of", "the", "C1412615#ent", "<e2>", "has", "been", "identified", "to", "be", "important", "in", "hematopoiesis", "."], "h": {"id": "C0812313", "name": "C0812313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412615", "name": "C1412615#ent", "pos": [7, 8]}}
{"token": ["These", "infections", "included", "brucellosis", ",", "cholecystitis", ",", "conjunctivitis", ",", "enteric", "fever", "gastroenteritis", ",", "infective", "endocarditis", "meningitis", ",", "otitis", "media", "pneumonia", ",", "septicaemia", ",", "sorethroat", ",", "C0040843#ent", "<e1>", "urethritis", ",", "urinary", "tract", "infections", "and", "C0042267#ent", "<e2>", "."], "h": {"id": "C0040843", "name": "C0040843#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0042267", "name": "C0042267#ent", "pos": [33, 34]}}
{"token": ["The", "smallest", "bimolecular", "rates", "were", "observed", "for", "C0051169#ent", "<e1>", "bound", "camphor", ",", "cytochrome", "c", "oxidase", "and", "C0010796#ent", "<e2>"], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010796", "name": "C0010796#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "TCC-S", "cells", "with", "only", "C1835417#ent", "<e1>", "no", "normal", "ABL", "gene", "be", "a", "useful", "tool", "for", "functional", "study", "C1412097#ent", "<e2>", "in", "Ph+", "CML", "."], "h": {"id": "C1835417", "name": "C1835417#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [19, 20]}}
{"token": ["The", "C1420418#ent", "<e1>", "the", "human", "Y", "chromosome", "a", "gene", ",", "C1421579#ent", "<e2>", ",", "that", "encodes", "a", "zinc-finger", "protein"], "h": {"id": "C1420418", "name": "C1420418#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421579", "name": "C1421579#ent", "pos": [10, 11]}}
{"token": ["Molecular", "analysis", "the", "loci", "assigned", "to", "the", "Y", "chromosome", "absence", "of", "the", "C1420418#ent", "<e1>", "presence", "of", "the", "other", "studied", "loci", "(", "C1421579#ent", "<e2>", ",", "AMEL-Y", "and", "STS-Y", ")", "."], "h": {"id": "C1420418", "name": "C1420418#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421579", "name": "C1421579#ent", "pos": [21, 22]}}
{"token": ["The", "45", "K", "subunit", "C1418625#ent", "<e1>", "PAFAH-45", "K", ")", "is", "the", "product", "of", "a", "candidate", "C0079429#ent", "<e2>", "for", "Miller-Dieker", "lissencephaly"], "h": {"id": "C1418625", "name": "C1418625#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["However", ",", "C0771029#ent", "<e1>", "may", "be", "superior", "to", "itraconazole", "for", "the", "treatment", "of", "C0040261#ent", "<e2>", "another", "recalcitrant", "fungal", "disease", "because", "C0771029#ent", "<e1>", "more", "rapidly", "penetrates", "the", "nail", "plate"], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0771029", "name": "C0771029#ent", "pos": [2, 3]}}
{"token": ["We", "examined", "the", "effect", "of", "C0071097#ent", "<e1>", ",", "a", "peroxisome", "proliferator-activated", "receptor-gamma", "(", ")", "agonist", "of", "the", "C1257987#ent", "<e2>", "on", "dopaminergic", "nerve", "cell", "death", "glial", "activation", "the", "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine", "(", "MPTP", ")", "mouse", "model", "Parkinson's", "disease"], "h": {"id": "C0071097", "name": "C0071097#ent", "pos": [5, 6]}, "relation": "has_structural_class", "t": {"id": "C1257987", "name": "C1257987#ent", "pos": [17, 18]}}
{"token": ["C0071097#ent", "<e1>", "is", "a", "C1257987#ent", "<e2>", "that", "increases", "insulin", "sensitivity", "target", "tissues", "."], "h": {"id": "C0071097", "name": "C0071097#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C1257987", "name": "C1257987#ent", "pos": [4, 5]}}
{"token": ["Some", "drugs", "such", "as", "actinomycin", "D", "cycloheximide", ",", "cytochalasin", "B", "C0009262#ent", "<e1>", ",", "vinblastine", "and", "C0021974#ent", "<e2>", "have", "been", "tested", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021974", "name": "C0021974#ent", "pos": [15, 16]}}
{"token": ["In", "the", "Freunds", "adjuvant", "chronic", "uveitis", "model", "C0730749#ent", "<e1>", "was", "also", "very", "effective", "with", "LE", "and", "C0011777#ent", "<e2>", "showing", "similar", "activity", "."], "h": {"id": "C0730749", "name": "C0730749#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [16, 17]}}
{"token": ["The", "C0027203#ent", "<e1>", "levels", "in", "C0023343#ent", "<e2>", "of", "different", "types", "showed", "elevations", "in", "following", "order", ",", "Erythema", "Nodosum", "Leprosum", "ENL", ")", "greater", "than", "Lepromatous", "greater", "than", "Borderline", "greater", "than", "Tuberculoid", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [5, 6]}}
{"token": ["It", "is", "speculated", "that", "these", "C0086376#ent", "<e1>", "are", "all", "glycosulphohydrolases", ",", "involved", "with", "desulphatation", "of", "C0019142#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019142", "name": "C0019142#ent", "pos": [15, 16]}}
{"token": ["The", "modified", "C0014442#ent", "<e1>", "was", "soluble", "and", "active", "in", "C0014994#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014994", "name": "C0014994#ent", "pos": [9, 10]}}
{"token": ["After", "the", "completion", "of", "C0064906#ent", "<e1>", "treatment", "a", "decrease", "in", "C2699751#ent", "<e2>", "scores", "from", "19.6", "to", "10.2", "was", "seen", "."], "h": {"id": "C0064906", "name": "C0064906#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2699751", "name": "C2699751#ent", "pos": [10, 11]}}
{"token": ["Expression", "of", "the", "C1171766#ent", "<e1>", "Escherichia", "coli", "in", "active", "C0027203#ent", "<e2>", "that", "phosphorylated", "casein", "phosvitin", ",", "and", "the", "peptide", "substrate", "."], "h": {"id": "C1171766", "name": "C1171766#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["Our", "data", "show", "that", "ascorbate", "in", "aerobic", "plasma", "can", "reduce", "vitamin", "E", "radical", "the", "C0003967#ent", "<e1>", "be", "recycled", "by", "a", "C0003402#ent", "<e2>"], "h": {"id": "C0003967", "name": "C0003967#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [20, 21]}}
{"token": ["The", "antiperoxidative", "enzymatic", "activities", "of", "C0003967#ent", "<e1>", "dehydroascorbate", "reductase", "glutathione", "reductase", "catalase", "and", "the", "content", "of", "the", "C0003402#ent", "<e2>", "glutathione", "were", "followed", "in", "the", "legume", "Retama", "Retama", "reatem", ")", "in", "the", "desert", "."], "h": {"id": "C0003967", "name": "C0003967#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [17, 18]}}
{"token": ["The", "cause", ",", "although", "not", "yet", "clearly", "defined", ",", "is", "believed", "to", "be", "related", "to", "bile", "stasis", "ischemia", ",", "bacterial", "infection", "C0243026#ent", "<e1>", ",", "the", "activation", "of", "C0015528#ent", "<e2>", "and", "the", "Shwarzman", "reaction"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0015528", "name": "C0015528#ent", "pos": [27, 28]}}
{"token": ["Familial", "male-limited", "precocious", "puberty", "C0249071#ent", "<e1>", ")", "is", "a", "rare", "disease", "caused", "by", "C0669365#ent", "<e2>", "activating", "mutations", "in", "the", "luteinizing", "hormone", "receptor", "LH-R", ")", "gene", "."], "h": {"id": "C0249071", "name": "C0249071#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [13, 14]}}
{"token": ["Ex", "vivo", "interleukin", "(IL)-1beta", ",", "but", "not", "C1516869#ent", "<e1>", "release", "was", "also", "depressed", "during", "the", "acute", "stage", "C0041466#ent", "<e2>"], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041466", "name": "C0041466#ent", "pos": [17, 18]}}
{"token": ["C1961835#ent", "<e1>", "type", "3", "characterized", "by", "C0005940#ent", "<e2>", "hematological", "symptoms"], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [6, 7]}}
{"token": ["C1961835#ent", "<e1>", "be", "considered", "in", "cases", "with", "hepatosplenomegaly", "and", "C0005940#ent", "<e2>", "unknown", "causes", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [9, 10]}}
{"token": ["C1258847#ent", "<e1>", "activity", ",", "measured", "with", "the", "three", "C1254351#ent", "<e2>", "by", "hydrolysis", "of", "4-nitrophenyl", "acetate", "increased", "by", "all", "pretreatments", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}}
{"token": ["It", "was", "shown", "that", "RNase", "III", "cosediments", "with", "membrane", "preparation", "C1883559#ent", "<e1>", "well", "as", "C0073240#ent", "<e2>", "overexpressing", "cells"], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0073240", "name": "C0073240#ent", "pos": [14, 15]}}
{"token": ["3H-Acetylcholine", "secretion", "enhanced", "by", "C0242947#ent", "<e1>", "was", "depressed", "by", "carbachol", "and", "by", "C2936795#ent", "<e2>", "was", "not", "influenced", "by", "drugs", "acting", "at", "beta", "adrenoceptors", "purinoceptors", "."], "h": {"id": "C0242947", "name": "C0242947#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936795", "name": "C2936795#ent", "pos": [12, 13]}}
{"token": ["Both", "IGF-1", "and", "c-kit", "ligand", "C1366480#ent", "<e1>", ")", "cause", "an", "additive", "increase", "in", "C0079068#ent", "<e2>", "mRNA", "in", "human", "CFU-E", "in", "conjunction", "with", "EPO", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", "to", "Bcl-XL", ",", "C1366480#ent", "<e1>", "blocked", "ADR-induced", "increases", "in", "C0079068#ent", "<e2>", "and", "inhibited", "the", "expression", "of", "p21WAF1/CIP1", "and", "of", "the", "BRCA1", "protein", "MDA-MB-453", "cells", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [11, 12]}}
{"token": ["We", "found", "statistically", "significant", "associations", "of", "PD", "with", "C4084845#ent", "<e1>", "polymorphisms", "in", "older", "patients", "and", "with", "a", "C0007407#ent", "<e2>", "polymorphism", "in", "younger", "subjects", "and", "in", "women", "."], "h": {"id": "C4084845", "name": "C4084845#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007407", "name": "C0007407#ent", "pos": [17, 18]}}
{"token": ["Three", "days", "after", "fluorocitrate", "infusion", "the", "activity", "of", "C4084845#ent", "<e1>", "was", "reduced", ",", "whereas", "C0007407#ent", "<e2>", "and", "PDE", "activities", "were", "increased", "."], "h": {"id": "C4084845", "name": "C4084845#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007407", "name": "C0007407#ent", "pos": [14, 15]}}
{"token": ["The", "second", "child", "presented", "at", "age", "7", "years", "with", "C0011603#ent", "<e1>", "dermatopathologic", "findings", "of", "C0162852#ent", "<e2>", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162852", "name": "C0162852#ent", "pos": [14, 15]}}
{"token": ["A", "case", "is", "reported", "in", "which", "a", "paraplegic", "patient", "with", "full", "sensory", "ablation", "C1367475#ent", "<e1>", "experienced", "phantom", "C0030196#ent", "<e2>", "after", "actual", "amputation", "of", "one", "of", "his", "legs", "."], "h": {"id": "C1367475", "name": "C1367475#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [17, 18]}}
{"token": ["So", "far", "FK228", "is", "the", "most", "potent", "among", "the", "HDAC", "(", "C1333891#ent", "<e1>", "inhibitors", "that", "block", "the", "activation", "of", "both", "C4084905#ent", "<e2>", "and", "another", "kinase", "AKT", "downstream", "of", "PI-3", "kinase"], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [20, 21]}}
{"token": ["These", "data", "indicate", "the", "possible", "local", "synthesis", "of", "angiostatin", "following", "acute", "renal", "failure", "C1705280#ent", "<e1>", ")", "and", "suggest", "a", "possible", "role", "for", "C0623362#ent", "<e2>", "in", "this", "activity", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [22, 23]}}
{"token": ["The", "data", "show", "that", ",", "in", "vivo", "the", "C0032950#ent", "<e1>", "conjunction", "with", "the", "inflammatory", "compound", "C2697656#ent", "<e2>", "act", "to", "enhance", "BM", "NS", "activity", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [15, 16]}}
{"token": ["Together", "with", "the", "markedly", "different", "tissue", "expression", "patterns", "for", "C1419096#ent", "<e1>", "and", "Fas", "receptor", "our", "findings", "suggest", "that", "C0971654#ent", "<e2>", "C1419096#ent", "<e1>", "does", "not", "play", "a", "key", "role", "in", "the", "Fas-mediated", "death", "pathway", "."], "h": {"id": "C1419096", "name": "C1419096#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0971654", "name": "C0971654#ent", "pos": [18, 19]}}
{"token": ["C1419096#ent", "<e1>", "FAP-1", ")", "is", "a", "C0971654#ent", "<e2>", "binds", "the", "cytosolic", "tail", "Fas", "(", "Apo1", ",", "CD95", ")", ",", "presumably", "regulating", "Fas-induced", "apoptosis"], "h": {"id": "C1419096", "name": "C1419096#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0971654", "name": "C0971654#ent", "pos": [6, 7]}}
{"token": ["C1419096#ent", "<e1>", "is", "an", "intracellular", "C0971654#ent", "<e2>", "contains", "five", "PDZ", "domains"], "h": {"id": "C1419096", "name": "C1419096#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0971654", "name": "C0971654#ent", "pos": [5, 6]}}
{"token": ["Additionally", ",", "muscarinic", "receptors", "C3889643#ent", "<e1>", "slices", "activated", "PKC", "and", "the", "C0059239#ent", "<e2>", "a", "potential", "molecular", "link", "PKC", "and", "Src", ")", "in", "a", "PI3K-dependent", "manner", "."], "h": {"id": "C3889643", "name": "C3889643#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [11, 12]}}
{"token": ["C0057522#ent", "<e1>", "was", "more", "toxic", "than", "amiodarone", "in", "the", "cultured", "C0669372#ent", "<e2>", "."], "h": {"id": "C0057522", "name": "C0057522#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}}
{"token": ["A", "comparison", "of", "the", "predicted", "isoelectric", "points", "all", "known", "S", "subunits", "type", "I", "restriction", "modification", "C3541394#ent", "<e1>", "revealed", "values", "that", "correlated", "with", "the", "arrangement", "of", "C4042815#ent", "<e2>", "several", "families", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4042815", "name": "C4042815#ent", "pos": [25, 26]}}
{"token": ["Pig", "C0752224#ent", "<e1>", "and", "B", "are", "both", "composed", "of", "the", "same", "229", "C3539947#ent", "<e2>", "a", "figure", "resembling", "the", "number", "of", "amino", "acid", "residues", "found", "in", "other", "serine", "proteinases", "pancreas", "."], "h": {"id": "C0752224", "name": "C0752224#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}}
{"token": ["Hagfish", "deiodinating", "pathways", "resembled", "those", "of", "teleosts", "in", "requiring", "a", "thiol", "cofactor", "dithiothreitol", ",", "C0012789#ent", "<e1>", ")", "and", "in", "their", "inhibition", "by", "established", "C3537035#ent", "<e2>", "by", "TH", "analogues", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3537035", "name": "C3537035#ent", "pos": [23, 24]}}
{"token": ["These", "retrospective", "data", "that", "external", "pneumatic", "calf", "compression", "helps", "to", "prevent", "C0149871#ent", "<e1>", "patients", "with", "C0038525#ent", "<e2>", "delayed", "operation", ",", "bedrest", ",", "and", "antifibrinolytic", "agents", "used", "."], "h": {"id": "C0149871", "name": "C0149871#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [15, 16]}}
{"token": ["C0265493#ent", "<e1>", "more", "common", "in", "C0018681#ent", "<e2>", "sufferers", "than", "in", "non-headache", "subjects", "."], "h": {"id": "C0265493", "name": "C0265493#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [5, 6]}}
{"token": ["The", "specific", "C0001645#ent", "<e1>", "atenolol", "and", "betaxolol", "(", "C1420369#ent", "<e2>", ")", "and", "ICI", "118,551", "beta-2", ")", "were", "inactive", "by", "themselves", "and", "in", "interaction", "with", "TFMPP", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [8, 9]}}
{"token": ["The", "present", "study", "investigated", "the", "effects", "of", "C0772125#ent", "<e1>", "its", "flavonoid", "fractions", "on", "C3853624#ent", "<e2>", "and", "alpha-glucosidase", "activity", "in", "vitro"], "h": {"id": "C0772125", "name": "C0772125#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3853624", "name": "C3853624#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "the", "role", "of", "the", "liver-enriched", "protein", "C1415594#ent", "<e1>", "HLF", ")", ",", "in", "mediating", "transcriptional", "regulation", "the", "C1366370#ent", "<e2>", "IX", "genes", "."], "h": {"id": "C1415594", "name": "C1415594#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [18, 19]}}
{"token": ["These", "are", "the", "major", "phenotypes", "observed", "during", "the", "aging", "of", "C0018889#ent", "<e1>", ",", "suggesting", "that", "the", "reduction", "of", "C3538704#ent", "<e2>", "causes", "early", "aging", "or", "progeria-like", "phenotypes", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [18, 19]}}
{"token": ["6-Propylthiouracil", "(", "PTU", ")", ",", "a", "widely", "used", "antithyroid", "drug", "the", "treatment", "of", "C0339143#ent", "<e1>", "is", "also", "a", "potent", "inhibitor", "of", "Type", "I", "iodothyronine", "deiodinase", "C1333565#ent", "<e2>", ")", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333565", "name": "C1333565#ent", "pos": [25, 26]}}
{"token": ["Spondyloarthropathies", "are", "a", "cluster", "of", "interrelated", "and", "overlapping", "C1290884#ent", "<e1>", "primarily", "include", "ankylosing", "spondylitis", "C0085435#ent", "<e2>", "and", "the", "arthritis", "associated", "with", "psoriasis", "and", "inflammatory", "bowel", "diseases"], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085435", "name": "C0085435#ent", "pos": [14, 15]}}
{"token": ["In", "the", "case", "of", "C0525678#ent", "<e1>", ",", "merlin", "acts", "downstream", "of", "the", "C1334306#ent", "<e2>", "complex", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334306", "name": "C1334306#ent", "pos": [12, 13]}}
{"token": ["Our", "findings", "may", "suggest", "that", "the", "primary", "association", "of", "C0030807#ent", "<e1>", "is", "with", "C1416272#ent", "<e2>", "."], "h": {"id": "C0030807", "name": "C0030807#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416272", "name": "C1416272#ent", "pos": [13, 14]}}
{"token": ["A", "differential", "diagnosis", "haematogenous", "osteomyelitis", "congenital", "syphilis", "C1517744#ent", "<e1>", ",", "scurvy", ",", "hypervitaminosis", "A", "trauma", ",", "Caffey's", "disease", "and", "C0162316#ent", "<e2>", "discussed", "."], "h": {"id": "C1517744", "name": "C1517744#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [19, 20]}}
{"token": ["Cheilitis", "glandularis", "C1567075#ent", "<e1>", ")", "is", "a", "rare", "C1290884#ent", "<e2>", "usually", "affects", "the", "lips", "."], "h": {"id": "C1567075", "name": "C1567075#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [8, 9]}}
{"token": ["In", "particular", ",", "in", "C0878544#ent", "<e1>", "accompanied", "by", "C3203102#ent", "<e2>", "serious", "VSD", ",", "arterial", "transpositions", "VSD", ",", "etc", ".", ")"], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3203102", "name": "C3203102#ent", "pos": [8, 9]}}
{"token": ["The", "sinus", "slowing", "caused", "by", "adenosine", "and", "C2744579#ent", "<e1>", "was", "blocked", "by", "theophylline", "(", "a", "C1516869#ent", "<e2>", "and", "disappeared", "in", "the", "hearts", "pre-treated", "with", "islet-activating", "protein", "1AP", ")", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [15, 16]}}
{"token": ["To", "elucidate", "which", "dopamine", "receptor", "regulates", "aldosterone", "secretion", "the", "effects", "of", "specific", "C1414052#ent", "<e1>", "and", "D4", "antagonists", ",", "C0072953#ent", "<e2>", "and", "clozapine", ",", "respectively", ",", "were", "examined", "in", "cultured", "NCI-H295", "cells", "."], "h": {"id": "C1414052", "name": "C1414052#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0072953", "name": "C0072953#ent", "pos": [18, 19]}}
{"token": ["A", "strain", "of", "Shigella", "dysenteriae", "type", "1", "resistant", "to", "ampicillin", ",", "chloramphenicol", ",", "streptomycin", ",", "C0038760#ent", "<e1>", ",", "and", "tetracyclines", "has", "caused", "an", "epidemic", "of", "C0013369#ent", "<e2>", "northeast", "Zaire"], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013369", "name": "C0013369#ent", "pos": [25, 26]}}
{"token": ["Although", "C0014130#ent", "<e1>", "uncommon", "in", "black", "African", "children", ",", "C0030517#ent", "<e2>", "up", "37", "percent", "of", "all", "types", "of", "27", "C0014130#ent", "<e1>", "at", "University", "College", "Hospital", "Ibadan", ",", "Nigeria", "over", "a", "five-year", "period", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0030517", "name": "C0030517#ent", "pos": [9, 10]}}
{"token": ["The", "chromosomal", "rearrangement", "the", "C1366536#ent", "<e1>", "RAR", "alpha", "and", "PML", "genes", ",", "resulting", "in", "C3887967#ent", "<e2>", "fusion", "transcripts", "."], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [4, 5]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3887967", "name": "C3887967#ent", "pos": [14, 15]}}
{"token": ["The", "t(15;17)", "chromosomal", "translocation", "specific", "for", "acute", "promyelocytic", "leukemia", "APL", ")", ",", "fuses", "the", "PML", "gene", "to", "the", "C1366536#ent", "<e1>", "RAR", "alpha", "gene", ",", "resulting", "in", "expression", "of", "a", "C3887967#ent", "<e2>"], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [18, 19]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3887967", "name": "C3887967#ent", "pos": [29, 30]}}
{"token": ["A", "review", "is", "devoted", "to", "discussing", "the", "genetics", "of", "C0241910#ent", "<e1>", "chronic", "viral", "hepatitis", "B", "C", ",", "cholestatic", "and", "alcoholic", "liver", "diseases", "C0010324#ent", "<e2>", "alpha", ",", "antitripsin", "deficiency", "hereditary", "haemochromatosis", "Wilson's", "disease", "hepatocellular", "carcinoma"], "h": {"id": "C0241910", "name": "C0241910#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010324", "name": "C0010324#ent", "pos": [22, 23]}}
{"token": ["C1334505#ent", "<e1>", "suppression", "and", "hypermethylation", "at", "the", "CpG", "island", "the", "C1334505#ent", "<e1>", "promoter", "occurred", "6", "days", "after", "C1420204#ent", "<e1>", "treatment", ",", "indicating", "that", "epigenetic", "modifications", "C1334505#ent", "<e1>", "might", "be", "an", "early", "event", "tumorigenesis", "."], "h": {"id": "C1334505", "name": "C1334505#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420204", "name": "C1420204#ent", "pos": [17, 18]}}
{"token": ["Stimulation", "of", "the", "C2001899#ent", "<e1>", "promoter", "activity", "bFGF", "was", "reflected", "in", "substantial", "increase", "of", "the", "C0162745#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [15, 16]}}
{"token": ["Western", "blot", "analysis", "the", "identity", "of", "collagenase", ",", "as", "only", "matrix", "metalloproteinase-1", "rabbit", "antibodies", "against", "C2001899#ent", "<e1>", "N-terminal", "region", ")", "recognized", "both", "the", "isolated", "C0162745#ent", "<e2>", "and", "the", "63", "kDa", "fragment", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [15, 16]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [24, 25]}}
{"token": ["A", "common", "site", "of", "C1705572#ent", "<e1>", "p21", "was", "also", "phosphorylated", "by", "both", "PKC", "and", "C0010531#ent", "<e2>", ",", "although", "phosphopeptides", "of", "H-ras", "p21", "distinct", "from", "those", "of", "K-ras", "p21", "."], "h": {"id": "C1705572", "name": "C1705572#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [14, 15]}}
{"token": ["Herein", "we", "have", "sequenced", "the", "entire", "C1420705#ent", "<e1>", "including", "the", "promoter", "and", "C0022959#ent", "<e2>", "operator", "regions"], "h": {"id": "C1420705", "name": "C1420705#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022959", "name": "C0022959#ent", "pos": [12, 13]}}
{"token": ["These", "studies", "indicate", ",", "therefore", ",", "that", "C2744579#ent", "<e1>", "and", "other", "nucleoside", "triphosphates", "influence", "the", "ability", "of", "the", "C1334133#ent", "<e2>", "bind", "insulin", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [18, 19]}}
{"token": ["The", "reduced", "C2744579#ent", "<e1>", "level", "impaired", "C1334133#ent", "<e2>", "IR", ")", "autophosphorylation", "and", "tyrosine", "kinase", "activity", "substrates", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [6, 7]}}
{"token": ["Epilepsia", "partialis", "continua", "EPC", ")", "may", "occur", "during", "C0020457#ent", "<e1>", "has", "not", "been", "described", "with", "C0011880#ent", "<e2>"], "h": {"id": "C0020457", "name": "C0020457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011880", "name": "C0011880#ent", "pos": [15, 16]}}
{"token": ["Type", "2", "diabetes", "traditionally", "been", "associated", "with", "development", "of", "hyperglycemic", "C0020457#ent", "<e1>", "HHNKS", ")", ",", "yet", "evidence", "suggests", "that", "diabetic", "ketoacidosis", "C0011880#ent", "<e2>", ")", "is", "increasing", "among", "this", "population", "."], "h": {"id": "C0020457", "name": "C0020457#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011880", "name": "C0011880#ent", "pos": [21, 22]}}
{"token": ["Immunofluorescence", "showed", "that", "C1538607#ent", "<e1>", "abundance", "in", "kidney", "is", "highest", "in", "epithelial", "cells", "the", "C0022672#ent", "<e2>", "where", "it", "colocalizes", "with", "NCC", "near", "the", "apical", "membrane"], "h": {"id": "C1538607", "name": "C1538607#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022672", "name": "C0022672#ent", "pos": [14, 15]}}
{"token": ["A", "C1382176#ent", "<e1>", "inhibitory", "antibody", "produced", "more", "than", "95", "%", "inhibition", "of", "C0700563#ent", "<e2>", "hydroxylation", "in", "four", "human", "livers", "."], "h": {"id": "C1382176", "name": "C1382176#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0700563", "name": "C0700563#ent", "pos": [12, 13]}}
{"token": ["However", ",", "SUPERMIX", "lacks", "C1382176#ent", "<e1>", "did", "not", "hydroxylate", "the", "antidepressant", "C0700563#ent", "<e2>", ",", "a", "clinically", "relevant", "substrate", "of", "this", "enzyme", "."], "h": {"id": "C1382176", "name": "C1382176#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0700563", "name": "C0700563#ent", "pos": [11, 12]}}
{"token": ["The", "neoplastic", "cells", "immunoreactive", "for", "the", "B-cell", "marker", "C1417326#ent", "<e1>", "and", "were", "positive", "for", "C1704467#ent", "<e2>", "in", "2", "cases", "."], "h": {"id": "C1417326", "name": "C1417326#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [14, 15]}}
{"token": ["C1412739#ent", "<e1>", ",", "a", "recently", "identified", "C3812173#ent", "<e2>", "was", "shown", "to", "be", "a", "substrate", "of", "protein", "kinase", "C", "in", "vitro"], "h": {"id": "C1412739", "name": "C1412739#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3812173", "name": "C3812173#ent", "pos": [6, 7]}}
{"token": ["The", "cDNA", "probe", "detects", "two", "C0812377#ent", "<e1>", "polymorphisms", "in", "the", "C1706247#ent", "<e2>", "PLAUR", ")", "."], "h": {"id": "C0812377", "name": "C0812377#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706247", "name": "C1706247#ent", "pos": [10, 11]}}
{"token": ["The", "cDNA", "probe", "detects", "two", "C0812377#ent", "<e1>", "polymorphisms", "in", "the", "urokinase-type", "plasminogen", "activator", "receptor", "gene", "C1706247#ent", "<e2>", ")", "."], "h": {"id": "C0812377", "name": "C0812377#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706247", "name": "C1706247#ent", "pos": [15, 16]}}
{"token": ["The", "data", "indicate", "differential", "C0271889#ent", "<e1>", "mediation", "of", "the", "quail", "'s", "C1516876#ent", "<e2>", "distinct", "color", "preferences", "and", "suggest", "diverse", "subtelencephalic", "channels", "for", "mediation", "of", "approach", "responses", "stimulus", "preferences", "."], "h": {"id": "C0271889", "name": "C0271889#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [11, 12]}}
{"token": ["The", "purpose", "of", "the", "present", "study", "was", "to", "investigate", "the", "effects", "of", "intracystic", "injections", "of", "alcohol", "and", "C0001911#ent", "<e1>", "solutions", "on", "the", "C0013502#ent", "<e2>", "hepatobiliary", "system", "rabbits", "."], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [22, 23]}}
{"token": ["We", "have", "investigated", "the", "oral", "bioavailability", "of", "granules", "of", "C0001911#ent", "<e1>", ",", "a", "drug", "used", "for", "treating", "C0013502#ent", "<e2>", "in", "man", ",", "prepared", "by", "the", "solid", "dispersion", "technique"], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [17, 18]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "compare", "the", "effect", "of", "intracystic", "injection", "of", "C0001911#ent", "<e1>", "and", "hypertonic", "saline", "patients", "with", "C0013502#ent", "<e2>"], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [21, 22]}}
{"token": ["Ethinyl", "oestradiol", "and", "norethindrone", ",", "components", "of", "the", "combination", "oral", "C0009871#ent", "<e1>", "Ortho-Novum", "1/35", "also", "are", "substrates", "of", "C3714749#ent", "<e2>", "CYP3A4", "isozymes", "."], "h": {"id": "C0009871", "name": "C0009871#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3714749", "name": "C3714749#ent", "pos": [18, 19]}}
{"token": ["C0039902#ent", "<e1>", "and", "DTT", "C0872351#ent", "<e2>", "differ", "in", "their", "flexibility", ",", "which", "is", "a", "result", "of", "their", "attachment", "to", "the", "surface", "through", "one", "and", "two", "arms", ",", "respectively", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [4, 5]}}
{"token": ["The", "duplicated", "genes", "C1704997#ent", "<e1>", "and", "SSO2", "encode", "yeast", "homologues", "C1420498#ent", "<e2>", "perform", "an", "essential", "function", "fusion", "of", "secretory", "vesicles", "the", "plasma", "membrane"], "h": {"id": "C1704997", "name": "C1704997#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420498", "name": "C1420498#ent", "pos": [10, 11]}}
{"token": ["A", "case", "of", "severe", "hypokalaemia", "and", "C0475718#ent", "<e1>", "in", "connection", "with", "C0021186#ent", "<e2>", "treatment", "is", "reported", "."], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0021186", "name": "C0021186#ent", "pos": [11, 12]}}
{"token": ["The", "compound", "1", "significant", "inhibitory", "activity", "C0023835#ent", "<e1>", "and", "weak", "to", "moderate", "activity", "against", "C0008429#ent", "<e2>", "."], "h": {"id": "C0023835", "name": "C0023835#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008429", "name": "C0008429#ent", "pos": [14, 15]}}
{"token": ["One", "cDNA", "clone", "upregulated", "by", "HRG", "was", "identical", "to", "human", "ADP-ribosylation", "factor", "3", "ARF3", ")", ",", "a", "C1708136#ent", "<e1>", "vesicular", "trafficking", ",", "C0031671#ent", "<e2>", "activation", "and", "intracellular", "transport", "."], "h": {"id": "C1708136", "name": "C1708136#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [22, 23]}}
{"token": ["The", "diseases", "were", "Tay-Sachs", "disease", "ceroid-lipofuscinosis", "(", "Jansky-Bielschowsky", "type", ",", "Niemann-Pick", "disease", "type", "B", ",", "highly", "suspected", "C1412084#ent", "<e1>", ",", "I-cell", "disease", "mucolipidosis", "of", "the", "C0085131#ent", "<e2>", "Hurler", "disease", "Hunter", "disease", "Morquio", "disease"], "h": {"id": "C1412084", "name": "C1412084#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085131", "name": "C0085131#ent", "pos": [25, 26]}}
{"token": ["We", "describe", "a", "similar", "metabolic", "pattern", "of", "hyperketosis", ",", "ketonaciduria", ",", "and", "C6-C12", "dicarboxylic", "aciduria", "a", "patient", "with", "the", "C0175693#ent", "<e1>", "a", "patient", "with", "the", "C0270972#ent", "<e2>"], "h": {"id": "C0175693", "name": "C0175693#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0270972", "name": "C0270972#ent", "pos": [25, 26]}}
{"token": ["With", "C0003762#ent", "<e1>", "replacing", "arginine", "or", "with", "C0049190#ent", "<e2>", "or", "6-fluorotryptophan", "replacing", "tryptophan", "the", "induced", "enzyme", "had", "a", "lower", "catalytic", "activity-relative", "to", "antibody", "reactivity", "."], "h": {"id": "C0003762", "name": "C0003762#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0049190", "name": "C0049190#ent", "pos": [7, 8]}}
{"token": ["Searching", "for", "proteins", "that", "interact", "with", "C1414444#ent", "<e1>", "in", "Saccharomyces", "cerevisiae", "we", "isolated", "C1705228#ent", "<e2>", ",", "which", "encodes", "a", "serine/threonine", "phosphatase", "type", "2C", "."], "h": {"id": "C1414444", "name": "C1414444#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705228", "name": "C1705228#ent", "pos": [13, 14]}}
{"token": ["In", "terms", "of", "number", ",", "C3273514#ent", "<e1>", "had", "the", "heaviest", "projection", "to", "the", "zona", "incerta", "whereas", "C3540812#ent", "<e2>", "had", "the", "weakest", "."], "h": {"id": "C3273514", "name": "C3273514#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540812", "name": "C3540812#ent", "pos": [16, 17]}}
{"token": ["We", "also", "show", "that", "C1826645#ent", "<e1>", "is", "epistatic", "to", "REV3", "and", "RAD30", ",", "although", "the", "relationship", "of", "C1826645#ent", "<e1>", "with", "these", "C0017337#ent", "<e1>", "is", "different", "."], "h": {"id": "C1826645", "name": "C1826645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [21, 22]}}
{"token": ["The", "loss", "of", "BRCA-1", "promoter", "activity", "accompanied", "by", "accumulation", "of", "C0059735#ent", "<e1>", "and", "BAX-alpha", "mRNA", "and", "p53", "and", "C0080058#ent", "<e2>", "whereas", "levels", "of", "Bcl-2", "mRNA", "were", "reduced", "."], "h": {"id": "C0059735", "name": "C0059735#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [18, 19]}}
{"token": ["Although", "treatment", "with", "KP772", "induced", "expression", "of", "p53", "and", "p21Waf1", ",", "transfection", "of", "C2987364#ent", "<e1>", "p53", "into", "knock-out", "cells", "only", "marginally", "enhanced", "the", "C0010858#ent", "<e2>", "KP772", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [23, 24]}}
{"token": ["TNF", "increased", "the", "degradation", "of", "endogenous", "or", "transfected", "C1419771#ent", "<e1>", "which", "was", "blocked", "by", "treating", "cells", "with", "a", "C0033607#ent", "<e2>", "by", "infecting", "cells", "with", "small", "interfering", "against", "Smurf1", "or", "Smurf2", "."], "h": {"id": "C1419771", "name": "C1419771#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [18, 19]}}
{"token": ["These", "results", "suggested", "that", "the", "C0277565#ent", "<e1>", "states", "accompanied", "with", "C0020433#ent", "<e2>", "might", "have", "increased", "the", "intestinal", "absorption", ",", "or", "oral", "bioavailability", "of", "MRP2", "substrates", "by", "suppressing", "MRP2", "function", "at", "the", "proximal", "intestinal", "region"], "h": {"id": "C0277565", "name": "C0277565#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020433", "name": "C0020433#ent", "pos": [10, 11]}}
{"token": ["Excellent", "control", "post-stroke", "C0026650#ent", "<e1>", "achieved", "by", "conventional", "DBS", "and/or", "C1822783#ent", "<e2>", "in", "20", "of", "28", "patients", "with", "hemichoreoathetosis", ",", "hemiballism", "tremor", ",", "and", "motor", "weakness"], "h": {"id": "C0026650", "name": "C0026650#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1822783", "name": "C1822783#ent", "pos": [10, 11]}}
{"token": ["Stimulation", "of", "C0917964#ent", "<e1>", "cAMP", "synthesis", "by", "carbachol", "is", "attributed", "to", "activation", "of", "C1332758#ent", "<e2>", "mAChR", ")", ",", "as", "demonstrated", "by", "inhibition", "with", "atropine", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332758", "name": "C1332758#ent", "pos": [13, 14]}}
{"token": ["No", "interaction", "is", "found", "with", "C0812234#ent", "<e1>", ",", "RhoC", ",", "or", "C0139880#ent", "<e2>"], "h": {"id": "C0812234", "name": "C0812234#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0139880", "name": "C0139880#ent", "pos": [11, 12]}}
{"token": ["Selective", "chelation", "of", "Zn2+", "by", "o-phenanthroline", ",", "which", "reversibly", "inactivates", "the", "metalloproteinase", ",", "does", "not", "result", "in", "the", "degradation", "of", "the", "C1334706#ent", "<e1>", ",", "even", "with", "excess", "of", "C0072402#ent", "<e2>"], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [28, 29]}}
{"token": ["Besides", "phenylalanineaminopeptidase", ",", "a", "C1334706#ent", "<e1>", "and", "a", "C0072402#ent", "<e2>", "also", "detected", "in", "L.", "pneumophila", "filtrate", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [8, 9]}}
{"token": ["This", "article", "reviews", "rheumatoid", "arthritis", "a", "C0008679#ent", "<e1>", "primarily", "targets", "the", "joints", ",", "its", "treatment", "and", "C0003191#ent", "<e2>"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003191", "name": "C0003191#ent", "pos": [16, 17]}}
{"token": ["The", "agent", "also", "inhibited", "the", "enzyme", "activity", "was", "further", "augmented", "by", "12", "-", "0-tetradecanoylphorbol-13-acetate", "(", "C0032143#ent", "<e1>", ")", ",", "mezerein", "or", "C0041073#ent", "<e2>", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041073", "name": "C0041073#ent", "pos": [21, 22]}}
{"token": ["Chronic", "demyelination", "to", "secondary", "axonal", "degeneration", "is", "responsible", "for", "long-term", "disability", "in", "C0011302#ent", "<e1>", "as", "multiple", "sclerosis", "inherited", "demyelinating", "C0031117#ent", "<e2>"], "h": {"id": "C0011302", "name": "C0011302#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [19, 20]}}
{"token": ["Focal", "segmental", "glomerulosclerosis", "C0017668#ent", "<e1>", ")", ",", "a", "subtype", "of", "\"", "C3496337#ent", "<e2>", ",", "is", "not", "a", "single", "disease", "but", "a", "lesion", "that", "initially", "affects", "the", "glomerulus", "followed", "by", "the", "tubulointerstitium", "and", "renal", "vessels"], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C3496337", "name": "C3496337#ent", "pos": [11, 12]}}
{"token": ["C0042267#ent", "<e1>", "one", "of", "the", "most", "common", "C0012634#ent", "<e2>", "seen", "in", "the", "practice", "of", "office", "gynecology"], "h": {"id": "C0042267", "name": "C0042267#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [7, 8]}}
{"token": ["However", ",", "infections", "such", "as", "C0042267#ent", "<e1>", ",", "cervicitis", ",", "and", "endometritis", "are", "important", "C0012634#ent", "<e2>", "that", "may", "influence", "the", "reproduction", "of", "these", "animals", "."], "h": {"id": "C0042267", "name": "C0042267#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "an", "inorganic", "selenium", "salt", "C0031306#ent", "<e1>", "human", "neutrophilic", "granulocytes", "donors", "with", "a", "low", "activity", "of", "C1415275#ent", "<e2>", "been", "investigated", "."], "h": {"id": "C0031306", "name": "C0031306#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415275", "name": "C1415275#ent", "pos": [18, 19]}}
{"token": ["Complementation", "studies", "showed", "that", "PfPP1", "could", "rescue", "low", "C0002245#ent", "<e1>", "phenotype", "of", "Saccharomyces", "cerevisiae", "(", "C1418858#ent", "<e2>", ")", "mutant", ",", "strongly", "suggesting", "functional", "interaction", "of", "PfPP1", "and", "yeast", "proteins", "in", "glycogen", "metabolism"], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418858", "name": "C1418858#ent", "pos": [15, 16]}}
{"token": ["C1540033#ent", "<e1>", "is", "an", "activated", "C1449330#ent", "<e2>", "and", "like", "nephrocystin-1", ",", "is", "a", "known", "interactor", "of", "p130Cas", "."], "h": {"id": "C1540033", "name": "C1540033#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1449330", "name": "C1449330#ent", "pos": [5, 6]}}
{"token": ["Palmitate", "elongation", "was", "sensitive", "to", "arsenite", "addition", ",", "and", "C3496118#ent", "<e1>", "elongation", "to", "the", "presence", "of", "Triton", "X-100", "C3541971#ent", "<e2>", "."], "h": {"id": "C3496118", "name": "C3496118#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541971", "name": "C3541971#ent", "pos": [18, 19]}}
{"token": ["This", "finding", "demonstrated", "that", "the", "induction", "of", "apoptosis", "by", "C1415467#ent", "<e1>", "involved", "a", "phosphatase", "activity", "specifically", "that", "of", "C0287531#ent", "<e2>", "."], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0287531", "name": "C0287531#ent", "pos": [18, 19]}}
{"token": ["T2-TrpRS", "inhibited", "activation", "by", "flow", "of", "protein", "kinase", "B", "C0812228#ent", "<e1>", ")", ",", "extracellular", "signal-regulated", "kinase", "1/2", "and", "EC", "C1538973#ent", "<e2>", "prevented", "transcription", "of", "several", "shear", "stress-responsive", "genes"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1538973", "name": "C1538973#ent", "pos": [19, 20]}}
{"token": ["Animals", "were", "pretreated", "with", "allopurinol", "or", "C0669516#ent", "<e1>", "with", "catalase", ",", "before", "administration", "of", "C0235480#ent", "<e2>", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [14, 15]}}
{"token": ["Catalase", ",", "C0669516#ent", "<e1>", "SOD", ")", ",", "protease", "inhibitors", "the", "platelet-activating", "factor", "C0235480#ent", "<e2>", ")", "antagonist", "L-659,989", "had", "no", "effect"], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [12, 13]}}
{"token": ["A", "linear", "relationship", "observed", "between", "C0048244#ent", "<e1>", "binding", "and", "the", "loss", "of", "enzyme", "activity", "which", "extrapolates", "to", "a", "stoichiometry", "of", "8.0", "mol", "C0048244#ent", "<e1>", "derivatives", "per", "mol", "C0014442#ent", "<e1>"], "h": {"id": "C0048244", "name": "C0048244#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [27, 28]}}
{"token": ["C0676425#ent", "<e1>", "has", "chymotrypsin-like", "activities", "hydrolyzes", "the", "amide", "bonds", "of", "synthetic", "substrates", "C1421250#ent", "<e2>", "and", "Phe", "residues", "the", "P1", "position"], "h": {"id": "C0676425", "name": "C0676425#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421250", "name": "C1421250#ent", "pos": [12, 13]}}
{"token": ["Josamycin", "treatment", "was", "applied", "to", "various", "dermatological", "diseases", "C0702166#ent", "<e1>", ",", "pyoderma", ")", "and", "C0036916#ent", "<e2>", "bacteriological", "infections"], "h": {"id": "C0702166", "name": "C0702166#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [14, 15]}}
{"token": ["We", "studied", "the", "effects", "of", "TPA", "on", "the", "regulation", "of", "C1706384#ent", "<e1>", "expression", "in", "HL-60", "cells", "C0021345#ent", "<e2>", "differentiation", "."], "h": {"id": "C1706384", "name": "C1706384#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [16, 17]}}
{"token": ["Contrary", "to", "previous", "reports", ",", "many", "synovial", "fluid", "cryoproteins", "from", "C1419789#ent", "<e1>", ",", "Reiter's", "syndrome", "nonspecific", "acute", "polyarthritis", "gout", ",", "and", "C0153216#ent", "<e2>", "contained", "IgG", "and", "occasionally", "IgG-IgM", "complexes", "."], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0153216", "name": "C0153216#ent", "pos": [21, 22]}}
{"token": ["Hydroxychloroquine", "(", "C0020336#ent", "<e1>", ")", "is", "a", "4-aminoquinoline", "C0003374#ent", "<e2>", "for", "the", "treatment", "of", "autoimmune", "diseases"], "h": {"id": "C0020336", "name": "C0020336#ent", "pos": [2, 3]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [8, 9]}}
{"token": ["The", "inducible", "NOS", "(", "iNOS", ")", "isoform", "of", "the", "C0014442#ent", "<e1>", "is", "expressed", "in", "C1412137#ent", "<e2>", "response", "to", "lipopolysaccharide", "and", "inflammatory", "mediators"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [14, 15]}}
{"token": ["It", "is", "therefore", "unlikely", "that", "an", "unmodified", "C0014442#ent", "<e1>", "occurs", "in", "high", "concentrations", "in", "C1412137#ent", "<e2>", "be", "activated", "in", "vivo", "cAMP", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [14, 15]}}
{"token": ["The", "C2350558#ent", "<e1>", "recombinant", "luciferases", "can", "be", "used", "for", "C2744579#ent", "<e2>", "assay", "within", "the", "0.01", "-", "10000", "nM", "range", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [9, 10]}}
{"token": ["Phosphorylation", "of", "the", "C2350558#ent", "<e1>", "substrate", "takes", "place", "in", "the", "presence", "of", "C2744579#ent", "<e2>", "and", "a", "solubilized", "epidermal", "growth", "factor", "receptor", "preparation", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [12, 13]}}
{"token": ["To", "explore", "the", "role", "of", "reactive", "oxygen", "species", "C0812281#ent", "<e1>", ")", "in", "the", "in", "vitro", "activation", "of", "skin", "fibroblasts", "patients", "with", "C1290138#ent", "<e2>", "SSc", ")", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [21, 22]}}
{"token": ["Two", "case", "reports", "presented", "of", "C0014544#ent", "<e1>", "due", "to", "congenital", "cytomegalovirus", "treated", "with", "human", "C0751598#ent", "<e2>"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751598", "name": "C0751598#ent", "pos": [14, 15]}}
{"token": ["C0234133#ent", "<e1>", ",", "and", "at", "the", "age", "of", "57", ",", "C0152222#ent", "<e2>", "noted", "."], "h": {"id": "C0234133", "name": "C0234133#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0152222", "name": "C0152222#ent", "pos": [10, 11]}}
{"token": ["Deletion", "of", "the", "C", "terminus", "resulted", "in", "C1305923#ent", "<e1>", "that", "were", "significantly", "more", "soluble", "than", "C1419618#ent", "<e2>", "but", "were", "unable", "to", "form", "stable", "complexes", "with", "the", "other", "two", "subunits", "of", "RPA", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419618", "name": "C1419618#ent", "pos": [15, 16]}}
{"token": ["Two", "of", "these", "C1305923#ent", "<e1>", "were", "identified", "as", "C1419618#ent", "<e2>", "and", "RepA2", ",", "proteins", "encoded", "by", "the", "essential", "replication", "region", "pSM1/R100", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419618", "name": "C1419618#ent", "pos": [8, 9]}}
{"token": ["We", "show", "that", "C3811096#ent", "<e1>", "is", "a", "component", "of", "C1413935#ent", "<e2>", ",", "a", "complex", "required", "for", "dynein", "activity", "yeast", "and", "mammalian", "cells"], "h": {"id": "C3811096", "name": "C3811096#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413935", "name": "C1413935#ent", "pos": [9, 10]}}
{"token": ["Cells", "were", "labelled", "with", "fluorescent", "antibodies", "C1414463#ent", "<e1>", ",", "AR", ",", "FGF-2", "and", "C1514773#ent", "<e2>", "and", "the", "fluorescence", "intensity", "by", "flow", "cytometry"], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1514773", "name": "C1514773#ent", "pos": [13, 14]}}
{"token": ["Clinical", "investigations", "a", "recessive", "hereditary", "of", "highly", "progredient", "mostly", "motor", "polyneuropathy", "atrophy", "and", "C0427055#ent", "<e1>", "of", "distal", "muscle", "groups", "and", "electrophysiologic", "evidence", "of", "C1417685#ent", "<e2>", "lesion-delayed", "neural", "conduction", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417685", "name": "C1417685#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "that", "glomerular", "C1332656#ent", "<e1>", "influence", "the", "clinical", "conditions", "of", "patients", "with", "C3273507#ent", "<e2>", ",", "and", "complement", "activation", "generated", "in", "the", "early", "stage", "C3273507#ent", "<e2>", "."], "h": {"id": "C1332656", "name": "C1332656#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [14, 15]}}
{"token": ["The", "test", "may", "also", "be", "abnormal", "in", "C0553604#ent", "<e1>", "but", "is", "normal", "in", "C0027126#ent", "<e2>"], "h": {"id": "C0553604", "name": "C0553604#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0027126", "name": "C0027126#ent", "pos": [13, 14]}}
{"token": ["To", "highlight", "recent", "advances", "in", "understanding", "the", "clinical", "manifestations", "molecular", "genetics", "C0553604#ent", "<e1>", "with", "particular", "emphasis", "on", "the", "C0027126#ent", "<e2>"], "h": {"id": "C0553604", "name": "C0553604#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0027126", "name": "C0027126#ent", "pos": [18, 19]}}
{"token": ["It", "has", "been", "reported", "that", "the", "cholinesterase", "inhibitor", "C0527316#ent", "<e1>", ",", "improves", "cognitive", "decline", "patients", "with", "Parkinson's", "disease", "dementia", "C0011989#ent", "<e2>", ")", "."], "h": {"id": "C0527316", "name": "C0527316#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011989", "name": "C0011989#ent", "pos": [19, 20]}}
{"token": ["Advantages", "obtained", "control", "of", "sepsis", ",", "correction", "of", "C1263960#ent", "<e1>", "dialysis", "for", "chronic", "renal", "failure", "improvement", "in", "C0018802#ent", "<e2>", "and", "improvement", "in", "pulmonary", "function"], "h": {"id": "C1263960", "name": "C1263960#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["C0272173#ent", "<e1>", "is", "a", "rare", "from", "of", "C0027947#ent", "<e2>", "that", "is", "probably", "congenital", ",", "characterized", "by", "severe", "noncyclic", "neutropenia", "recurrent", "infections", "granulocytic", "hyperplasia", "the", "bone", "marrow", "and", "degenerative", "changes", "in", "mature", "neutrophils", "."], "h": {"id": "C0272173", "name": "C0272173#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [7, 8]}}
{"token": ["The", "term", "WHIM", "syndrome", "WHIMS", ")", "is", "an", "acronym", "describing", "a", "rare", "primary", "immunodeficiency", "disorder", "characterized", "by", "warts", ",", "hypogammaglobulinemia", ",", "immunodeficiency", ",", "and", "C0272173#ent", "<e1>", ",", "the", "unusual", "association", "of", "C0027947#ent", "<e2>", "with", "bone", "marrow", "myeloid", "hypercellularity"], "h": {"id": "C0272173", "name": "C0272173#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [31, 32]}}
{"token": ["Apparently", ",", "moderate", "levels", "of", "C0037231#ent", "<e1>", "repel", "water", "penetration", "the", "beads", ",", "and", "therefore", "minimize", "C0008281#ent", "<e2>", "release", "."], "h": {"id": "C0037231", "name": "C0037231#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008281", "name": "C0008281#ent", "pos": [16, 17]}}
{"token": ["Different", "levels", "of", "C0037231#ent", "<e1>", "were", "mixed", "with", "sodium", "alginate", "C0008281#ent", "<e2>", "maleate", "(", "as", "loaded", "model", "drug", ")", "."], "h": {"id": "C0037231", "name": "C0037231#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008281", "name": "C0008281#ent", "pos": [10, 11]}}
{"token": ["Our", "data", "indicate", "that", "despite", "being", "homologous", "in", "amino", "acid", "sequence", "C1422064#ent", "<e1>", "and", "BACE1", "have", "distinct", "functions", "and", "C1710463#ent", "<e2>"], "h": {"id": "C1422064", "name": "C1422064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [19, 20]}}
{"token": ["Histologically", ",", "a", "C0151436#ent", "<e1>", "seen", "in", "addition", "to", "the", "usual", "features", "of", "C0162852#ent", "<e2>", "."], "h": {"id": "C0151436", "name": "C0151436#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162852", "name": "C0162852#ent", "pos": [13, 14]}}
{"token": ["The", "biologically", "active", "form", "the", "essential", "trace", "element", "C1445745#ent", "<e1>", "is", "believed", "to", "be", "the", "oligopeptide", "C0077918#ent", "<e2>", "."], "h": {"id": "C1445745", "name": "C1445745#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0077918", "name": "C0077918#ent", "pos": [16, 17]}}
{"token": ["The", "activity", "of", "a", "new", "oxazolidinone", "antimicrobial", "C1122070#ent", "<e1>", ",", "was", "assessed", "against", ">", "500", "clinical", "C1875400#ent", "<e2>", "of", "enterococci", "representing", "six", "species", "."], "h": {"id": "C1122070", "name": "C1122070#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [16, 17]}}
{"token": ["The", "activity", "of", "C1122070#ent", "<e1>", "against", "250", "highly", "resistant", "pneumococci", "and", "267", "drug-susceptible", "C1875400#ent", "<e2>", "was", "determined", "."], "h": {"id": "C1122070", "name": "C1122070#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "the", "structural", "and", "functional", "similarities", "between", "human", "and", "tupaia", "C1413218#ent", "<e1>", "indicate", "that", "C1705340#ent", "<e2>", "represent", "a", "useful", "model", "system", "characterize", "the", "molecular", "interaction", "the", "HCV", "envelope", "C1413218#ent", "<e1>", "on", "primary", "hepatocytes", "."], "h": {"id": "C1413218", "name": "C1413218#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [15, 16]}}
{"token": ["We", "have", "constructed", "HCMV", "recombinants", "that", "express", "C2987364#ent", "<e1>", "full-length", "C1336602#ent", "<e2>", "86", "but", "do", "not", "express", "the", "C1336602#ent", "<e2>", "40-", "and", "60-kDa", "proteins", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336602", "name": "C1336602#ent", "pos": [10, 11]}}
{"token": ["Gas", "liquid", "chromatographic", "analysis", "to", "reveal", "the", "presence", "of", "either", "hexose", "or", "hexosamine", ",", "indicating", "that", "C3539540#ent", "<e1>", "is", "probably", "not", "a", "C0061642#ent", "<e2>", "."], "h": {"id": "C3539540", "name": "C3539540#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0061642", "name": "C0061642#ent", "pos": [22, 23]}}
{"token": ["The", "profile", "of", "urinary", "salicylate", "metabolites", "was", "determined", "after", "the", "oral", "administration", "C0050537#ent", "<e1>", "ASA", ")", "to", "CCl4-cirrhotic", "rats", ",", "CCl4-cirrhotic", "rats", "treated", "with", "C0009262#ent", "<e2>", "for", "1", "month", ",", "and", "control", "groups"], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [24, 25]}}
{"token": ["Conversely", ",", "and", "despite", "earlier", "reports", "showing", "GPR54", "expression", "in", "the", "C0032002#ent", "<e1>", ",", "the", "potential", "physiological", "roles", "of", "C1334307#ent", "<e2>", "at", "this", "gland", "have", "remained", "elusive", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334307", "name": "C1334307#ent", "pos": [19, 20]}}
{"token": ["In", "eukaryotes", ",", "apart", "from", "catalyzing", "the", "translation", "termination", "reaction", "C1414467#ent", "<e1>", "binds", "to", "and", "activates", "another", "factor", ",", "C1706342#ent", "<e2>", ",", "which", "is", "a", "ribosome-dependent", "and", "eRF1-dependent", "GTPase", "."], "h": {"id": "C1414467", "name": "C1414467#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706342", "name": "C1706342#ent", "pos": [19, 20]}}
{"token": ["Succinylcholine", "is", "a", "short-acting", "depolarizing", "neuromuscular", "blocker", "to", "facilitate", "intubation", ";", "C0030311#ent", "<e1>", "is", "a", "longer-acting", ",", "C0027867#ent", "<e2>", "employed", "to", "control", "ventilation", "pediatric", "patients", "."], "h": {"id": "C0030311", "name": "C0030311#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [17, 18]}}
{"token": ["We", "report", "the", "successful", "treatment", "of", "disseminated", "C0276758#ent", "<e1>", "skin", "manifestations", "a", "severely", "neutropenic", ",", "immunocompromised", "host", "with", "C0393080#ent", "<e2>", ",", "a", "new", "second-generation", "triazole", "."], "h": {"id": "C0276758", "name": "C0276758#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0393080", "name": "C0393080#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "whether", "the", "degree", "of", "residual", "activity", "from", "the", "mutant", "phenylalanine", "hydroxylase", "PAH", ")", "allele", "affected", "phenylalanine", "metabolism", "heterozygotes", "for", "C0751434#ent", "<e1>", "(", "PKU", ")", "or", "C0751435#ent", "<e2>", "HPA", ")", "."], "h": {"id": "C0751434", "name": "C0751434#ent", "pos": [21, 22]}, "relation": "has_manifestation", "t": {"id": "C0751435", "name": "C0751435#ent", "pos": [27, 28]}}
{"token": ["During", "fasting", "and", "in", "C0011854#ent", "<e1>", "elevated", "levels", "of", "C4054191#ent", "<e2>", "PGC-1alpha", ")", "induce", "expression", "of", "the", "Cyp7A1", "gene", "overexpression", "of", "PGC-1alpha", "in", "hepatoma", "cells", "stimulates", "bile", "acid", "synthesis", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4054191", "name": "C4054191#ent", "pos": [9, 10]}}
{"token": ["Indirect", "immunofluorescence", "confocal", "microscopy", "showed", "that", "C3539717#ent", "<e1>", "colocalized", "with", "glial", "fibrillary", "acidic", "protein", "indicating", "that", "C1422666#ent", "<e2>", "is", "expressed", "in", "astrocytes", "."], "h": {"id": "C3539717", "name": "C3539717#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1422666", "name": "C1422666#ent", "pos": [16, 17]}}
{"token": ["It", "is", "now", "evident", "from", "multiple", "crystal", "structures", "the", "catalytic", "domains", "C0012920#ent", "<e1>", "site", "specific", "recombinases", "derive", "from", "a", "common", "C0040676#ent", "<e2>", "of", "forming", "a", "DNA-(3'-phosphotyrosyl)-enzyme", "intermediate", "."], "h": {"id": "C0012920", "name": "C0012920#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040676", "name": "C0040676#ent", "pos": [20, 21]}}
{"token": ["Glucose-dependent", "insulinotropic", "polypeptide", "GIP", ")", "is", "a", "42-amino", "acid", "peptide", "produced", "by", "K", "cells", "the", "mammalian", "proximal", "small", "intestine", "is", "a", "potent", "C0304402#ent", "<e1>", "of", "insulin", "release", "in", "the", "presence", "of", "C0020456#ent", "<e2>", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [31, 32]}}
{"token": ["Some", "direct", "dopamine", "receptor", "C0304402#ent", "<e1>", "(", "lergotrile", ",", "bromocriptine", ",", "apomorphine", ")", "caused", "C0020456#ent", "<e2>", ",", "but", "other", "agonists", "(", "e.g.", "pergolide", ")", "did", "not", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [14, 15]}}
{"token": ["The", "dynamic", "was", "studied", "of", "the", "enzyme", "activity", "ChE", ",", "C1705550#ent", "<e1>", ",", "Ald", ",", "GOAT", ",", "C3887708#ent", "<e2>", ",", "LDG", ",", "and", "CPh", "in", "30", "newborn", "calves", "."], "h": {"id": "C1705550", "name": "C1705550#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3887708", "name": "C3887708#ent", "pos": [17, 18]}}
{"token": ["There", "were", "essential", "differences", "in", "the", "sensitivity", "to", "inhibition", "by", "GMP", ":", "the", "level", "of", "inhibition", "was", "more", "than", "80", "%", "for", "C0061779#ent", "<e1>", "only", "35", "%", "for", "the", "C1883559#ent", "<e2>"], "h": {"id": "C0061779", "name": "C0061779#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [29, 30]}}
{"token": ["The", "first", "meta-binding", "site", "located", "outside", "of", "the", "TM", "bundle", ",", "between", "C1420385#ent", "<e1>", "and", "C1866810#ent", "<e2>", ",", "and", "the", "second", "higher", "energy", "site", "positioned", "immediately", "underneath", "C1420385#ent", "<e1>", "."], "h": {"id": "C1866810", "name": "C1866810#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420385", "name": "C1420385#ent", "pos": [12, 13]}}
{"token": ["C0054827#ent", "<e1>", ",", "racemic", "2-[3-chloro-4(3-pyrrolinyl", ")", "phenyl", "]", "C0072186#ent", "<e2>", "was", "evaluated", "for", "its", "ability", "to", "inhibit", "the", "conversion", "of", "arachidonic", "acid", "prostaglandin", "E2", "sheep", "seminal", "vesicle", "prostaglandin", "synthase", "in", "vitro"], "h": {"id": "C0054827", "name": "C0054827#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072186", "name": "C0072186#ent", "pos": [8, 9]}}
{"token": ["Because", "all", "three", "genes", "hybridized", "to", "DNA", "fragments", "different", "lengths", "it", "seems", "unlikely", "that", "the", "gene", "for", "C0014914#ent", "<e1>", "is", "located", "very", "close", "to", "C0242987#ent", "<e2>", "and", "ERBB2", "."], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0242987", "name": "C0242987#ent", "pos": [24, 25]}}
{"token": ["These", "results", "indicate", "that", "the", "Gly16", "and", "Gln27", "alleles", "of", "the", "C1367657#ent", "<e1>", "an", "increased", "risk", "for", "C0020538#ent", "<e2>", "this", "northern", "Han", "Chinese", "population", "."], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [17, 18]}}
{"token": ["A", "lower", "concentration", "of", "carbamoylcholine", "(", "6.5.10(-7", ")", "M", ")", "had", "the", "same", "quantitative", "effect", "as", "2.10(-5", ")", "M", "C0022245#ent", "<e1>", "on", "the", "increase", "of", "C0017860#ent", "<e2>"], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [25, 26]}}
{"token": ["4", "These", "results", "suggest", "that", "C0770909#ent", "<e1>", "may", "be", "a", "useful", "drug", "in", "the", "chronic", "treatment", "C0002962#ent", "<e2>", "in", "this", "respect", "may", "possess", "advantages", "over", "beta-adrenoceptor", "antagonists"], "h": {"id": "C0770909", "name": "C0770909#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [16, 17]}}
{"token": ["The", "cause", "of", "death", "was", "rapidly", "progressive", "C0152966#ent", "<e1>", "to", "DIC", "and", "circulatory", "failure", "which", "appeared", "to", "cause", "C0242073#ent", "<e2>", "hemorrhage", "without", "pneumonia", "."], "h": {"id": "C0152966", "name": "C0152966#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242073", "name": "C0242073#ent", "pos": [18, 19]}}
{"token": ["elusive", "disorders", "(", "arterial", "dissection", "C0014038#ent", "<e1>", ",", "systemic", "and", "central", "vasculitides", "and", "C0151945#ent", "<e2>", "which", "have", "the", "potential", "for", "neurologic", "catastrophe", "are", "often", "not", "obvious", "on", "routine", "CT", "brain", "imaging"], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151945", "name": "C0151945#ent", "pos": [13, 14]}}
{"token": ["C1537745#ent", "<e1>", "expression", "was", "markedly", "reduced", "in", "p53-null", "C1704969#ent", "<e2>", "p53-mutated", "DU145", "cells", "compared", "with", "LNCaP", "cells", "expressing", "wild-type", "p53", "."], "h": {"id": "C1537745", "name": "C1537745#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704969", "name": "C1704969#ent", "pos": [8, 9]}}
{"token": ["These", "data", "disclose", "a", "functional", "correlation", "between", "CK2", "and", "C0755322#ent", "<e1>", ",", "and", "suggest", "that", "reversible", "phosphorylation", "of", "C1414692#ent", "<e2>", "plays", "a", "role", "in", "the", "regulation", "of", "growth", "rate", "budding", "in", "S.", "cerevisiae"], "h": {"id": "C0755322", "name": "C0755322#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414692", "name": "C1414692#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "C1417809#ent", "<e1>", "infusion", "increased", "ANP", "plasma", "levels", "in", "both", "C1427067#ent", "<e2>", "and", "SDR", "."], "h": {"id": "C1417809", "name": "C1417809#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1427067", "name": "C1427067#ent", "pos": [12, 13]}}
{"token": ["To", "test", "the", "feasibility", "of", "using", "liposomes", "to", "deliver", "therapeutic", "agents", "the", "lungs", ",", "the", "effect", "of", "C3274912#ent", "<e1>", "SOD", ")", "or", "C0007367#ent", "<e2>", "on", "pulmonary", "oxygen", "toxicity", "was", "studied", "in", "rats", "."], "h": {"id": "C3274912", "name": "C3274912#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [22, 23]}}
{"token": ["Anaesthesia", "was", "induced", "with", "a", "C0039855#ent", "<e1>", "5", "mg.kg-1", "iv", ")", "followed", "by", "C0012792#ent", "<e2>", "(", "1", "mg.kg-1", ")", "."], "h": {"id": "C0039855", "name": "C0039855#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [13, 14]}}
{"token": ["In", "Group", "I", "1.5", "-", "2", "mg/kg", "of", "C0039855#ent", "<e1>", "were", "given", "intravenously", "as", "pretreatment", "before", "the", "injection", "of", "C0012792#ent", "<e2>"], "h": {"id": "C0039855", "name": "C0039855#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [19, 20]}}
{"token": ["Anesthesia", "was", "induced", "with", "C0039855#ent", "<e1>", "(", "500", "mg", ")", "and", "C0012792#ent", "<e2>", "(", "140", "mg", ")", "iv", "and", "100", "%", "oxygen", "."], "h": {"id": "C0039855", "name": "C0039855#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [11, 12]}}
{"token": ["C1414533#ent", "<e1>", "cDNA", "contained", "an", "C1412821#ent", "<e2>", "encoding", "1,045", "amino", "acids", "a", "total", "length", "of", "3.4", "kb", "."], "h": {"id": "C1414533", "name": "C1414533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [5, 6]}}
{"token": ["The", "reaction", "rate", "greater", "with", "maltotriose", "than", "with", "maltose", ",", "and", "with", "increasing", "size", "of", "the", "cyclomalto-oligosaccharide", "(", "C1832231#ent", "<e1>", "less", "than", "C1864399#ent", "<e2>", "less", "than", "cG8", ")", "."], "h": {"id": "C1832231", "name": "C1832231#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1864399", "name": "C1864399#ent", "pos": [22, 23]}}
{"token": ["Our", "analysis", "of", "dLeu", "and", "the", "other", "mutants", "has", "enabled", "us", "to", "C1516876#ent", "<e1>", "define", "the", "regions", "in", "the", "N-terminal", "200", "residues", "of", "C1413864#ent", "<e2>", "which", "are", "required", "for", "efficient", "viral", "growth", "Vero", "cells"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413864", "name": "C1413864#ent", "pos": [23, 24]}}
{"token": ["From", "these", "observations", "we", "conclude", "that", "C0058980#ent", "<e1>", "the", "mouse", "C1825621#ent", "<e2>", ",", "double-stranded", "RNA-dependent", "kinase", "PKR", "."], "h": {"id": "C0058980", "name": "C0058980#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1825621", "name": "C1825621#ent", "pos": [10, 11]}}
{"token": ["The", "2'-5'", "oligoadenylate", "synthetases", "the", "protein", "kinase", "C0058980#ent", "<e1>", "are", "both", "C1825621#ent", "<e2>", ",", "double-stranded", "RNA-dependent", "proteins", "play", "important", "roles", "in", "the", "antiviral", "effects", "the", "interferons", "and", "in", "cellular", "growth", "control"], "h": {"id": "C0058980", "name": "C0058980#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1825621", "name": "C1825621#ent", "pos": [11, 12]}}
{"token": ["The", "first", "is", "affected", "by", "PC", "with", "cold-induced", "stiffness", "and", "C0427055#ent", "<e1>", "in", "addition", "to", "C0238357#ent", "<e2>", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0238357", "name": "C0238357#ent", "pos": [15, 16]}}
{"token": ["A", "new", "hydrogel", "binder", "C0718050#ent", "<e1>", ",", "has", "recently", "become", "available", "for", "use", "in", "C0085681#ent", "<e2>", "patients", "with", "renal", "failure"], "h": {"id": "C0718050", "name": "C0718050#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0085681", "name": "C0085681#ent", "pos": [14, 15]}}
{"token": ["Overall", ",", "C0718050#ent", "<e1>", "is", "a", "valuable", "option", "for", "the", "management", "of", "C0085681#ent", "<e2>", "in", "patients", "with", "ESRD", "on", "haemodialysis", "."], "h": {"id": "C0718050", "name": "C0718050#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0085681", "name": "C0085681#ent", "pos": [12, 13]}}
{"token": ["Clinical", "trial", "indicate", "that", "C0055147#ent", "<e1>", "is", "an", "effective", "and", "well", "tolerated", "treatment", "for", "C0035457#ent", "<e2>", "chronic", "idiopathic", "urticaria", "adults", ",", "and", "for", "C0035457#ent", "<e2>", "children", "."], "h": {"id": "C0055147", "name": "C0055147#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [14, 15]}}
{"token": ["Treatment", "of", "cell", "cultures", "C0917964#ent", "<e1>", "(", "25", "microM", ")", "induced", "C1522428#ent", "<e2>", "beta", "transcripts", "in", "granulosa", "but", "not", "theca", "cells"], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [11, 12]}}
{"token": ["C0432255#ent", "<e1>", "is", "active", "on", "various", "amines", "(", "sarcosine", ",", "C1871076#ent", "<e2>", ",", "glycine", ")", "and", "d-amino", "acids", "d-alanine", ",", "d-proline", ")", "."], "h": {"id": "C0432255", "name": "C0432255#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1871076", "name": "C1871076#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "find", "that", "a", "novel", "coiled-coil", "protein", "golgin-45", "with", "the", "medial-Golgi", "matrix", "protein", "GRASP55", "and", "the", "GTP", "form", "of", "C1826755#ent", "<e1>", "but", "not", "other", "C1423498#ent", "<e2>"], "h": {"id": "C1826755", "name": "C1826755#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1423498", "name": "C1423498#ent", "pos": [26, 27]}}
{"token": ["Glucose-6-phosphate", "dehydrogenase", "C2939465#ent", "<e1>", ")", "deficiency", "is", "the", "most", "common", "human", "C0025517#ent", "<e2>", "southern", "China"], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "we", "propose", "that", "a", "high", "level", "of", "C2939465#ent", "<e1>", "in", "adipocytes", "may", "mediate", "the", "onset", "of", "C0025517#ent", "<e2>", "obesity", "by", "increasing", "the", "oxidative", "stress", "inflammatory", "signals"], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [18, 19]}}
{"token": ["C0014868#ent", "<e1>", "candida", "infection", "diagnosed", "by", "esophago-gastro-duodenoscopy", "and", "treated", "with", "C0028978#ent", "<e2>", "and", "fluconazole", "."], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [10, 11]}}
{"token": ["Disruption", "of", "the", "ACBP", "C0079429#ent", "<e1>", "causes", "a", ">", "5-fold", "activation", "of", "C3811772#ent", "<e2>", "transcription", "and", "a", "similar", "increase", "in", "C3811772#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3811772", "name": "C3811772#ent", "pos": [12, 13]}}
{"token": ["Predisposing", "diseases", "are", "prostatitis", ",", "epididymitis", ",", "urinary", "stones", "C0041296#ent", "<e1>", ",", "cirrhosis", "of", "the", "liver", ",", "C0020538#ent", "<e2>", "hematologic", "diseases"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [17, 18]}}
{"token": ["No", "C0016964#ent", "<e1>", "is", "present", "on", "the", "sperm", "surface", ",", "whereas", "two", "C0017976#ent", "<e2>", ",", "beta-N-acetylglucosaminidase", "(", ")", "and", "alpha-mannosidase", "(", "Man'ase", ")", ",", "have", "been", "evidenced", "."], "h": {"id": "C0016964", "name": "C0016964#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017976", "name": "C0017976#ent", "pos": [12, 13]}}
{"token": ["C0813872#ent", "<e1>", "injections", "into", "anterior", "thalamus", "limbic", "cortex", "injury", "and", "C2936800#ent", "<e2>", "injections", "into", "anterior", "thalamus", "injury", "produced", "by", "systemic", "C0813872#ent", "<e1>", "."], "h": {"id": "C2936800", "name": "C2936800#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [0, 1]}}
{"token": ["Rapid-onset", "obesity", "with", "hypoventilation", ",", "hypothalamic", ",", "autonomic", "dysregulation", "and", "neural", "tumor", "C4053506#ent", "<e1>", ")", "is", "a", "newly", "described", "C0039082#ent", "<e2>", "that", "can", "cause", "cardiorespiratory", "arrests", "death", "."], "h": {"id": "C4053506", "name": "C4053506#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", ",", "we", "have", "investigated", "the", "presence", "of", "C0031404#ent", "<e1>", "mRNA", "in", "C0771711#ent", "<e2>", ",", "islets", "and", "cultured", "\u00df", "cells", "."], "h": {"id": "C0031404", "name": "C0031404#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [15, 16]}}
{"token": ["The", "authors", "conclude", "that", ",", "in", "some", "instances", ",", "low-dose", "amphotericin", "B", "will", "effectively", "treat", "C0153252#ent", "<e1>", "resulting", "in", "little", "C1565662#ent", "<e2>", "and", "that", "the", "criteria", "for", "such", "treatment", "require", "re-evaluation", "."], "h": {"id": "C0153252", "name": "C0153252#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "the", "2", "C1414895#ent", "<e1>", "patients", "on", "C1705750#ent", "<e2>", "treatment", "did", "not", "show", "significantly", "lower", "levels", "of", "apoptotic", "neutrophils", "the", "bloodstream", "."], "h": {"id": "C1414895", "name": "C1414895#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705750", "name": "C1705750#ent", "pos": [8, 9]}}
{"token": ["In", "two", "patients", "with", "C0393538#ent", "<e1>", "only", "exons", "7", "8", "of", "the", "C1420257#ent", "<e2>", "deleted", "whereas", "exons", "5", "13", "of", "the", "neuronal", "apoptosis", "inhibitory", "protein", "gene", "present", "."], "h": {"id": "C0393538", "name": "C0393538#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [12, 13]}}
{"token": ["Almost", "all", "patients", "initially", "complained", "about", "C0086525#ent", "<e1>", "well", "as", "frequently", "about", "atypical", "functional", "complaints", "and", "C0233397#ent", "<e2>"], "h": {"id": "C0086525", "name": "C0086525#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0233397", "name": "C0233397#ent", "pos": [16, 17]}}
{"token": ["C0003404#ent", "<e1>", "determined", "by", "enzymatic", "inhibition", "gGAPDH", "of", "Trypanosoma", "cruzi", "C1366623#ent", "<e2>", "APRT", ")", "of", "Leishmania", "tarentolae"], "h": {"id": "C0003404", "name": "C0003404#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366623", "name": "C1366623#ent", "pos": [10, 11]}}
{"token": ["An", "C0242417#ent", "<e1>", "sensitive", "to", "C2985256#ent", "<e2>", "is", "apparently", "also", "operative", "."], "h": {"id": "C0242417", "name": "C0242417#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [5, 6]}}
{"token": ["However", ",", "urinary", "concentrations", "the", "prostacyclin", "metabolite", "2,3-dinor-6-ketoprostglandin", "C0906566#ent", "<e1>", "were", "significantly", "lower", "after", "1", "week", "of", "C0538927#ent", "<e2>", "treatment", "."], "h": {"id": "C0906566", "name": "C0906566#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [17, 18]}}
{"token": ["Second", ",", "C2987245#ent", "<e1>", "activates", "mitotic", "checkpoint", "signaling", "cascades", "binding", "to", "the", "C1416698#ent", "<e2>", "a", "microtubule", "motor", "protein"], "h": {"id": "C2987245", "name": "C2987245#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416698", "name": "C1416698#ent", "pos": [12, 13]}}
{"token": ["In", "these", "mice", ",", "expression", "from", "the", "C1414430#ent", "<e1>", "promoter", "is", "reported", "by", "C0005220#ent", "<e2>", "."], "h": {"id": "C1414430", "name": "C1414430#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "C1419080#ent", "<e1>", "was", "identified", "as", "potential", "candidate", "gene", "in", "C0027719#ent", "<e2>"], "h": {"id": "C1419080", "name": "C1419080#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027719", "name": "C0027719#ent", "pos": [12, 13]}}
{"token": ["This", "result", "shows", "that", "there", "is", "a", "high", "potential", "for", "the", "PC", "purification", "from", "CFIV-1", "by", "appropriately", "adjusting", "the", "C0020923#ent", "<e1>", "concentration", "and", "pH", "in", "the", "C1705077#ent", "<e2>", "process", "."], "h": {"id": "C0020923", "name": "C0020923#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705077", "name": "C1705077#ent", "pos": [26, 27]}}
{"token": ["The", "effects", "of", "pH", "and", "C0020923#ent", "<e1>", "on", "adsorption", "and", "elution", "of", "PC", "and", "FII", "during", "C1705077#ent", "<e2>", "process", "were", "studied", "."], "h": {"id": "C0020923", "name": "C0020923#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705077", "name": "C1705077#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "C0543476#ent", "<e1>", "plus", "prednisolone", "plus", "C0066469#ent", "<e2>", "is", "a", "highly", "effective", "antiemetic", "treatment", "in", "patients", "receiving", "moderately", "emetogenic", "chemotherapy", "refractory", "to", "antiemetic", "therapy", "with", "C0543476#ent", "<e1>", "or", "prednisolone", "plus", "C0066469#ent", "<e2>", "."], "h": {"id": "C0543476", "name": "C0543476#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0066469", "name": "C0066469#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "the", "number", "of", "cycles", "completed", "with", "C0543476#ent", "<e1>", "was", "significantly", "higher", "the", "number", "completed", "with", "prednisolone", "plus", "C0066469#ent", "<e2>", ",", "but", "the", "anti-emetic", "efficacy", "both", "treatments", "declined", "during", "multiple", "cycles", "moderately", "emetogenic", "chemotherapy"], "h": {"id": "C0543476", "name": "C0543476#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0066469", "name": "C0066469#ent", "pos": [20, 21]}}
{"token": ["We", "examined", "the", "action", "of", "C1334912#ent", "<e1>", "on", "desensitization", "in", "recombinant", "NMDA", "receptors", "of", "NMDA", "receptor", "1", "C1706269#ent", "<e2>", ")", "and", "NR2A", "subunits", "."], "h": {"id": "C1334912", "name": "C1334912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706269", "name": "C1706269#ent", "pos": [17, 18]}}
{"token": ["The", "opposite", "C0235267#ent", "<e1>", "received", "a", "control", "solution", "without", "C0301366#ent", "<e2>", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0301366", "name": "C0301366#ent", "pos": [9, 10]}}
{"token": ["Cationic", "amphiphilic", "drugs", "like", "C0033229#ent", "<e1>", ",", "propranolol", ",", "and", "chloroquine", "inhibit", "C0024361#ent", "<e2>", "in", "vitro"], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024361", "name": "C0024361#ent", "pos": [12, 13]}}
{"token": ["However", ",", "C0015137#ent", "<e1>", "failed", "to", "inhibit", "rTNF", "C0171965#ent", "<e2>", "IL-8", "secretion", ",", "suggesting", "that", "C0015137#ent", "<e1>", "regulation", "of", "NHK", "cytokine", "secretion", "also", "depend", "on", "the", "stimulus", "."], "h": {"id": "C0015137", "name": "C0015137#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0171965", "name": "C0171965#ent", "pos": [8, 9]}}
{"token": ["When", "multivessel", "involvement", "with", "aneurysmal", "dilatation", "is", "observed", "in", "patients", "with", "C0016052#ent", "<e1>", "the", "possibility", "of", "C0741160#ent", "<e2>", "any", "of", "the", "arteries", "should", "be", "considered", "."], "h": {"id": "C0016052", "name": "C0016052#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0741160", "name": "C0741160#ent", "pos": [16, 17]}}
{"token": ["Administration", "of", "C1420066#ent", "<e1>", "results", "in", "rapid", "appearance", "and", "disappearance", "of", "C0013974#ent", "<e2>", "and", "cephaeline", "in", "plasma", "becoming", "almost", "undetectable", "at", "3", "hours", "."], "h": {"id": "C1420066", "name": "C1420066#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013974", "name": "C0013974#ent", "pos": [11, 12]}}
{"token": ["A", "paper", "towel", "test", "was", "performed", "to", "objectively", "demonstrate", "the", "physical", "sign", "C0042025#ent", "<e1>", "leakage", "on", "C0010200#ent", "<e2>", "."], "h": {"id": "C0042025", "name": "C0042025#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [16, 17]}}
{"token": ["Both", "types", "of", "incontinence", "are", "in", "many", "patients", "found", "together", "and", "factors", "causing", "C0042025#ent", "<e1>", "for", "instance", "C0010200#ent", "<e2>", ",", "may", "also", "cause", "spontaneous", ",", "uninhibited", "detrusor", "contractions", "."], "h": {"id": "C0042025", "name": "C0042025#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [17, 18]}}
{"token": ["A", "retrospective", "chart", "analysis", "was", "conducted", "on", "all", "new", "elderly", "hypertensive", "patients", "referred", "to", "a", "C0020538#ent", "<e1>", "clinic", "who", "were", "being", "treated", "with", "reserpine", "or", "C0025741#ent", "<e2>", "plus", "a", "diuretic", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0025741", "name": "C0025741#ent", "pos": [25, 26]}}
{"token": ["Hypertension", "(", "C0020538#ent", "<e1>", ")", "is", "an", "important", "risk", "factor", "C0025741#ent", "<e2>", ",", "and", "angiotensin", "II", "ANG", "II", "is", "the", "most", "important", "hormone", "associated", "with", "C0020538#ent", "<e1>", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0025741", "name": "C0025741#ent", "pos": [10, 11]}}
{"token": ["The", "fine", "structure", "glycoprotein", "asparagine-linked", "oligosaccharide", "structures", "synthesized", "in", "the", "presence", "or", "absence", "of", "C0813866#ent", "<e1>", "was", "analyzed", "by", "lectin", "affinity", "chromatography", "ion", "exchange", "chromatography", "and", "methylation", "analysis", "radiolabeled", "C0017953#ent", "<e2>", "prepared", "by", "Pronase", "digestion"], "h": {"id": "C0813866", "name": "C0813866#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017953", "name": "C0017953#ent", "pos": [29, 30]}}
{"token": ["The", "effects", "of", "C0011849#ent", "<e1>", "and", "exercise", "training", "on", "the", "activity", "of", "pyruvate", "dehydrogenase", "C0034345#ent", "<e2>", ")", "complex", "in", "skeletal", "muscle", "examined", "in", "rats", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034345", "name": "C0034345#ent", "pos": [14, 15]}}
{"token": ["Correlation", "of", "the", "above", "lesions", "with", "previously", "described", "lung", "syndromes", "SLE", "such", "as", "C3714636#ent", "<e1>", "hemorrhagic", "lung", "disease", "chronic", "interstitial", "fibrosis", "lupus", "cor", "pulmonale", "pleurisy", ",", "and", "\"", "shrinking", "C0158940#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0158940", "name": "C0158940#ent", "pos": [29, 30]}}
{"token": ["The", "so-called", "C2936739#ent", "<e1>", "to", "the", "group", "of", "diseases", "designated", "\"", "C0018203#ent", "<e2>", ",", "characterized", "by", "recurrent", "suppurative", "infections", "the", "skin", ",", "eczema", ",", "nail", "dystrophy", "conjunctivitis", ",", "lymphadenitis", "and", "pulmonary", "infections"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018203", "name": "C0018203#ent", "pos": [11, 12]}}
{"token": ["Infusion", "of", "the", "C0001641#ent", "<e1>", "phentolamine", "into", "the", "PVN", "completely", "reduced", "the", "C0004099#ent", "<e2>", "increases", "in", "blood", "glucose", "plasma", "corticosterone", "concentrations", "."], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "C0001641#ent", "<e1>", "not", "prevent", "C0004099#ent", "<e2>", "lipid", "mobilization", "SCAT", "while", "exerting", "fat", "cell", "beta-adrenergic", "receptor", "blockade", "."], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [6, 7]}}
{"token": ["Green", "tea", "consumption", "had", "no", "effect", "C1335081#ent", "<e1>", "Ser(326", ")", "homozygotes", "or", "C0919534#ent", "<e2>", "carriers", "."], "h": {"id": "C1335081", "name": "C1335081#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0919534", "name": "C0919534#ent", "pos": [12, 13]}}
{"token": ["The", "C0039082#ent", "<e1>", "of", "paroxysmal", "nocturnal", "haemoglobinuria", "a", "C0024899#ent", "<e2>", "by", "the", "production", "of", "abnormal", "cells", "all", "three", "lines", "of", "the", "peripheral", "blood"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024899", "name": "C0024899#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "risk", "of", "cerebral", "hemorrhage", "be", "higher", "in", "patients", "with", "C0038454#ent", "<e1>", "in", "subjects", "with", "transient", "ischemic", "attack", "(", "C0007787#ent", "<e2>", ")", "or", "partial", "occlusion"], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [21, 22]}}
{"token": ["We", "studied", "the", "activation", "of", "MARK", "and", "identified", "the", "upstream", "kinase", "C4084849#ent", "<e1>", ",", "a", "member", "of", "the", "C0031727#ent", "<e2>"], "h": {"id": "C4084849", "name": "C4084849#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}}
{"token": ["The", "faster", "efflux", "when", "cells", "contain", "n-3", "PUFAs", "may", "account", "for", "part", "of", "the", "reduction", "in", "risk", "of", "C0010068#ent", "<e1>", "increases", "in", "dietary", "n-3", "PUFAs", "(", "C0016157#ent", "<e2>", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [18, 19]}, "relation": "may_be_prevented_by", "t": {"id": "C0016157", "name": "C0016157#ent", "pos": [26, 27]}}
{"token": ["One", "should", "remember", "that", "Addison's", "disease", "mask", "the", "presence", "of", "C1384672#ent", "<e1>", "and", "that", "glucocorticoid", "replacement", "therapy", "can", "cause", "C0039613#ent", "<e2>", "crisis", "."], "h": {"id": "C1384672", "name": "C1384672#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039613", "name": "C0039613#ent", "pos": [19, 20]}}
{"token": ["To", "report", "a", "case", "of", "acute", "dystonic", "reaction", "to", "methotrimeprazine", "in", "a", "patient", "with", "untreated", "C1384672#ent", "<e1>", ",", "emphasizing", "the", "potential", "increased", "sensitivity", "of", "C0039613#ent", "<e2>", "patients", "to", "the", "extrapyramidal", "adverse", "effects", "antipsychotic", "drugs"], "h": {"id": "C1384672", "name": "C1384672#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0039613", "name": "C0039613#ent", "pos": [24, 25]}}
{"token": ["We", "show", "here", "that", ",", "as", "in", "human", "cells", "the", "S.", "cerevisiae", "binding", "factor", "composed", "of", "MSH2", "and", "a", "new", "functional", "MutS", "homologue", "C0879393#ent", "<e1>", ",", "identified", "by", "its", "homology", "to", "C1706576#ent", "<e2>", "."], "h": {"id": "C0879393", "name": "C0879393#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1706576", "name": "C1706576#ent", "pos": [31, 32]}}
{"token": ["A", "germ-line", "mutation", "C0879393#ent", "<e1>", "(", "also", "called", "C1706576#ent", "<e2>", ")", "was", "found", "in", "a", "hereditary", "nonpolyposis", "colorectal", "cancer", "patient", "in", "whom", "germ-line", "mutations", "hMSH2", ",", "hMSH3", ",", "or", "hMLH1", "had", "not", "been", "detected", "."], "h": {"id": "C0879393", "name": "C0879393#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706576", "name": "C1706576#ent", "pos": [8, 9]}}
{"token": ["A", "similar", "or", "stronger", "(", "VP", ",", "SV", ")", "increase", "of", "C1708620#ent", "<e1>", "was", "observed", "for", "TP", ";", "C1417772#ent", "<e2>", "and", "DNP", "were", "ineffective", "."], "h": {"id": "C1708620", "name": "C1708620#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417772", "name": "C1417772#ent", "pos": [18, 19]}}
{"token": ["The", "inbred", "genetic", "hypercalciuric", "(", "GHS", ")", "rats", "develop", "C1161320#ent", "<e1>", "apatite", ")", "stones", "when", "C0342895#ent", "<e2>", "a", "normal", "1.2", "%", "calcium", "diet"], "h": {"id": "C1161320", "name": "C1161320#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [15, 16]}}
{"token": ["Inhibitors", "of", "CYP3A4", "(", "C1142644#ent", "<e1>", "have", "a", "minor", "effect", "on", "C0023660#ent", "<e2>", "pharmacokinetics", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [4, 5]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [11, 12]}}
{"token": ["Inhibitors", "of", "C1142644#ent", "<e1>", "(", "cytochrome", "P450", "3A4", "have", "a", "minor", "effect", "on", "C0023660#ent", "<e2>", "pharmacokinetics", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [2, 3]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [13, 14]}}
{"token": ["C0248719#ent", "<e1>", "reduced", "atherosclerosis", "in", "C1704299#ent", "<e2>", "least", "partly", "via", "the", "suppression", "of", "oxidative", "stress"], "h": {"id": "C0248719", "name": "C0248719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704299", "name": "C1704299#ent", "pos": [5, 6]}}
{"token": ["Application", "of", "shear", "stress", "12dyn/cm(2", ")", "to", "these", "cells", "led", "to", "significant", "increases", "in", "their", "expression", "of", "von", "Willebrand", "Factor", "C1706508#ent", "<e1>", "both", "the", "C0017337#ent", "<e2>", "and", "protein", "levels"], "h": {"id": "C1706508", "name": "C1706508#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}}
{"token": ["The", "supplementation", "of", "C1414863#ent", "<e1>", "attenuated", "the", "formation", "of", "C0047645#ent", "<e2>", "in", "the", "striatum", "resulting", "from", "METH", "treatment", "."], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0047645", "name": "C0047645#ent", "pos": [9, 10]}}
{"token": ["C0015620#ent", "<e1>", "was", "found", "to", "reduce", "pruritus", "associated", "with", "acute", "urticaria", "intensity", "of", "C0042109#ent", "<e2>", ",", "and", "body", "surface", "area", "affected", "by", "C0042109#ent", "<e2>", "without", "causing", "sedation", "."], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [13, 14]}}
{"token": ["2-Mercaptopropionic", "acid", "been", "identified", "as", "a", "normal", "metabolite", "of", "2-mercaptopropionylglycine", "(", "C0076425#ent", "<e1>", ")", "when", "this", "C0013227#ent", "<e2>", "was", "given", "to", "humans", "and", "dogs", "."], "h": {"id": "C0076425", "name": "C0076425#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "report", "that", "ornithine", "decarboxylase", "regulated", "at", "the", "translational", "level", "by", "polyamines", "in", "difluoromethylornithine-resistant", "mouse", "myeloma", "cells", "that", "overproduce", "the", "C0014442#ent", "<e1>", "due", "to", "amplification", "of", "an", "C0029282#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [28, 29]}}
{"token": ["Hepatocyte", "growth", "factor", "activator", "C4284777#ent", "<e1>", ")", "is", "a", "serine", "protease", "converts", "hepatocyte", "growth", "factor", "C0399440#ent", "<e2>", ")", "into", "its", "active", "form"], "h": {"id": "C4284777", "name": "C4284777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0399440", "name": "C0399440#ent", "pos": [15, 16]}}
{"token": ["Hepatocyte", "growth", "factor", "activator", "C4284777#ent", "<e1>", ")", "can", "activate", "the", "single-chain", "hepatocyte", "growth", "factor", "C0399440#ent", "<e2>", ")", "required", "for", "embryonic", "development"], "h": {"id": "C4284777", "name": "C4284777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0399440", "name": "C0399440#ent", "pos": [14, 15]}}
{"token": ["The", "antimycotic", "imidazole", "derivative", "C0009074#ent", "<e1>", "is", "employed", "locally", "for", "the", "treatment", "of", "genitourinary", "tract", "C0026946#ent", "<e2>", "is", "formulated", "as", "creams", ",", "foams", ",", "tablets", ",", "gels", ",", "irrigations", ",", "or", "pessaries", "."], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [15, 16]}}
{"token": ["The", "obligatory", "hepatobiliary", "excretion", "the", "C1418654#ent", "<e1>", ",", "erythropoietic", "increased", "accumulating", "C0072497#ent", "<e2>", "in", "protoporphyria", "strains", "the", "excretory", "function", "the", "liver", "."], "h": {"id": "C1418654", "name": "C1418654#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0072497", "name": "C0072497#ent", "pos": [11, 12]}}
{"token": ["On", "the", "other", "hand", ",", "ConA", "4", "-", "1", "cells", "express", "almost", "exclusively", "C4049874#ent", "<e1>", "-", "3", ",", "a", "novel", "non-glycosylated", "procyclin", "C0597298#ent", "<e2>", "with", "23", "EP", "repeats", "no", "site", "glycosylation", "."], "h": {"id": "C4049874", "name": "C4049874#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [22, 23]}}
{"token": ["Nek2", "activity", "increases", "with", "autophosphorylation", "and", "addition", "of", "C1562036#ent", "<e1>", "decreases", "in", "the", "presence", "of", "C1418858#ent", "<e2>", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418858", "name": "C1418858#ent", "pos": [15, 16]}}
{"token": ["Using", "C1562036#ent", "<e1>", "the", "fractional", "phosphatase", "activities", "of", "calcineurin", ",", "protein", "phosphatases", "1", "C1418858#ent", "<e2>", ")", ",", "2A", "(", "PP2A", ")", ",", "and", "2C", "(", "PP2C", ")", "were", "determined", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418858", "name": "C1418858#ent", "pos": [13, 14]}}
{"token": ["We", "experienced", "some", "cases", "of", "C0474368#ent", "<e1>", "deterioration", "of", "low", "back", "pain", "C0023222#ent", "<e2>", "headache", ",", "nausea", ",", "hypertension", ",", "hypotension", ",", "and", "tachycardia", "as", "accidental", "complications", "caudal", "block", "."], "h": {"id": "C0474368", "name": "C0474368#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023222", "name": "C0023222#ent", "pos": [12, 13]}}
{"token": ["Importantly", ",", "our", "prepared", "anti-SR-PSOX", "mAb", ",", "which", "suppressed", "chemotactic", "activity", "C3538864#ent", "<e1>", ",", "significantly", "inhibited", "bacterial", "phagocytosis", "by", "human", "C0033036#ent", "<e2>", "including", "dendritic", "cells"], "h": {"id": "C3538864", "name": "C3538864#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [20, 21]}}
{"token": ["beta-Amyloid", "precursor", "protein", "APP", ")", "belongs", "to", "a", "family", "of", "homologous", "C1412466#ent", "<e1>", "APLPs", ")", "including", "C1412466#ent", "<e1>", "and", "APLP2", "."], "h": {"id": "C1412466", "name": "C1412466#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412466", "name": "C1412466#ent", "pos": [11, 12]}}
{"token": ["Based", "on", "the", "C0720099#ent", "<e1>", "of", "oliguria", "and/or", "anuria", ",", "the", "C0277554#ent", "<e2>", "classified", "as", "mild", "(", "n=6", ")", ",", "moderate", "(", "n=6", ")", ",", "or", "severe", "(", "n=16", ")", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0277554", "name": "C0277554#ent", "pos": [11, 12]}}
{"token": ["C0086376#ent", "<e1>", "expressed", "from", "human", "cDNA", "clones", "KIAA0390", "and", "C1704958#ent", "<e2>", ",", "which", "have", "partial", "similarities", "to", "ZNF219", ",", "also", "showed", "specific", "binding", "to", "the", "same", "core", "DNA", "sequence"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704958", "name": "C1704958#ent", "pos": [9, 10]}}
{"token": ["Recently", ",", "defects", "in", "several", "developmental", "pathways", "those", "operated", "by", "the", "C1335824#ent", "<e1>", "Nodal", "signaling", "factors", "been", "implicated", "as", "causes", "of", "C3273590#ent", "<e2>", "or", "laterality", "defects", "in", "humans", "."], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3273590", "name": "C3273590#ent", "pos": [21, 22]}}
{"token": ["Here", ",", "we", "report", "the", "identification", "of", "human", "C1335824#ent", "<e1>", "SHH", ")", "as", "HPE3-the", "first", "known", "gene", "to", "cause", "C3273590#ent", "<e2>", "."], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273590", "name": "C3273590#ent", "pos": [19, 20]}}
{"token": ["This", "investigation", "demonstrated", "a", "subclinical", "activation", "the", "components", "of", "the", "C0005779#ent", "<e1>", "leading", "to", "a", "C0398623#ent", "<e2>"], "h": {"id": "C0005779", "name": "C0005779#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [15, 16]}}
{"token": ["PBE-ALIGNm", "is", "a", "facility", "for", "mining", "C1538638#ent", "<e1>", "database", "for", "similar", "structures", "based", "on", "the", "alignment", "of", "C1720830#ent", "<e2>", "."], "h": {"id": "C1538638", "name": "C1538638#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1720830", "name": "C1720830#ent", "pos": [17, 18]}}
{"token": ["Both", "C0012695#ent", "<e1>", "(", "extracellular", "Ca2", "+", "chelator", ")", "and", "C0246569#ent", "<e2>", "(", "intracellular", "Ca2", "+", "chelator", ")", "effectively", "suppressed", "PrRP31", "(", "100", "nM)-induced", "dopamine", "secretion", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0246569", "name": "C0246569#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "a", "polymorphic", "CA-repeat", "5", "kb", "upstream", "of", "the", "C1538435#ent", "<e1>", "used", "as", "a", "marker", "in", "C0238288#ent", "<e2>", "and", "Centre", "d'Etude", "du", "Polymorphisme", "Humain", "families", "to", "perform", "linkage", "analysis"], "h": {"id": "C1538435", "name": "C1538435#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0238288", "name": "C0238288#ent", "pos": [18, 19]}}
{"token": ["The", "TNF-alpha-induced", "activation", "of", "c-Jun", "N-terminal", "kinase", "JNK", ")", ",", "C1705633#ent", "<e1>", ",", "and", "NF-kappaB", "was", "not", "affected", "by", "C1413800#ent", "<e2>", "stimulation", "."], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413800", "name": "C1413800#ent", "pos": [19, 20]}}
{"token": ["However", ",", "a", "C0085385#ent", "<e1>", "phenidone", ")", ",", "a", "serotonin", "receptor", "antagonist", "C0025842#ent", "<e2>", ")", "and", "H1", "and", "H2", "receptor", "antagonists", "clemastine", "and", "cimetidine", ",", "respectively", ")", "all", "failed", "to", "inhibit", "the", "reaction", "."], "h": {"id": "C0085385", "name": "C0085385#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025842", "name": "C0025842#ent", "pos": [12, 13]}}
{"token": ["Neonatal", "intrahepatic", "cholestasis", "by", "C1863844#ent", "<e1>", "NICCD", ",", "MIM#605814", ")", "is", "an", "inherited", "C0005944#ent", "<e2>", "from", "mutations", "of", "the", "gene", "SLC25A13", "which", "encodes", "citrin", ",", "a", "liver-type", "mitochondrial", "aspartate-glutamate", "carrier", "."], "h": {"id": "C1863844", "name": "C1863844#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [13, 14]}}
{"token": ["External", "genital", "and", "C0343729#ent", "<e1>", "acuminate", "condyloma", "were", "the", "first", "medical", "indication", "topical", "immune", "response", "C0165032#ent", "<e2>", "was", "approved", "for", "in", "1997", "."], "h": {"id": "C0343729", "name": "C0343729#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0165032", "name": "C0165032#ent", "pos": [15, 16]}}
{"token": ["Lethal", "graft-versus-host", "disease", "GVHD", ")", "can", "be", "induced", "after", "hematopoietic", "stem", "cell", "transplantation", "major", "C0024518#ent", "<e1>", "strains", "expressing", "multiple", "minor", "histocompatibility", "antigen", "C1337109#ent", "<e2>", ")", "differences", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337109", "name": "C1337109#ent", "pos": [22, 23]}}
{"token": ["Here", ",", "the", "C1305923#ent", "<e1>", "specifically", "induced", "migration", "of", "U937", "cells", "expressing", "the", "C1332699#ent", "<e2>", "(", "MIP-1alpha", "receptor", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332699", "name": "C1332699#ent", "pos": [13, 14]}}
{"token": ["C3887648#ent", "<e1>", "concentration", "in", "C0007384#ent", "<e2>", "rats", "returned", "to", "normal", "under", "these", "conditions", ":", "this", "parameter", "increased", "in", "the", "corpus", "striatum", "adrenal", "glands", "decreased", "in", "the", "hypothalamus", "to", "a", "control", "level", "in", "intact", "Wistar", "rats"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007384", "name": "C0007384#ent", "pos": [4, 5]}}
{"token": ["Based", "on", "electrophoretic", "mobility", "light", "chains", "L20", "and", "L17", ")", "seem", "to", "be", "the", "same", "for", "both", "C0022173#ent", "<e1>", "whilst", "the", "C1420192#ent", "<e2>", "different", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [21, 22]}}
{"token": ["Peptide", "mapping", "individual", "myosin", "C0022173#ent", "<e1>", "showed", "that", "the", "C1420192#ent", "<e2>", "IM", "were", "different", "from", "either", "fast", "or", "slow", "heavy", "chains"], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [9, 10]}}
{"token": ["Prader-Willi", "syndrome", "PWS", ")", ",", "most", "notably", "characterized", "by", "infantile", "hypotonia", "short", "stature", "C0028754#ent", "<e1>", "results", "from", "C0268487#ent", "<e2>", "in", "multiple", "genes", "are", "subject", "to", "genomic", "imprinting"], "h": {"id": "C0028754", "name": "C0028754#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "prostaglandin", "E2", "C0021246#ent", "<e1>", "on", "the", "generation", "of", "cytotoxic", "T-lymphocytes", "response", "to", "Mycobacterium", "tuberculosis", "C1826313#ent", "<e2>", ")", "antigens", "was", "compared", "between", "healthy", "controls", "rheumatoid", "arthritis", "patients", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826313", "name": "C1826313#ent", "pos": [17, 18]}}
{"token": ["Alcohol", "facilitates", "the", "development", "of", "C0348893#ent", "<e1>", "chronic", "atrophic", "gastritis", "though", "it", "has", "not", "been", "shown", "to", "cause", "C0030920#ent", "<e2>"], "h": {"id": "C0348893", "name": "C0348893#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [18, 19]}}
{"token": ["Helicobacter", "pylori", "C0348893#ent", "<e1>", "in", "some", "patients", "may", "lead", "to", "C0030920#ent", "<e2>", "while", "a", "subset", "of", "infected", "individuals", "develop", "gastric", "cancer", "gastric", "lymphoma"], "h": {"id": "C0348893", "name": "C0348893#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [10, 11]}}
{"token": ["Two", "genes", "from", "Caenorhabditis", "elegans", "Saccharomyces", "cerevisiae", "coding", "for", "C3540790#ent", "<e1>", "homologous", "to", "the", "Nudix", "hydrolase", "of", "C0069161#ent", "<e2>", "have", "been", "cloned", "and", "expressed", "in", "Escherichia", "coli"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0069161", "name": "C0069161#ent", "pos": [17, 18]}}
{"token": ["C0025842#ent", "<e1>", "is", "a", "serotonin", "antagonist", "is", "used", "as", "a", "long-term", "prophylactic", "treatment", "C0154723#ent", "<e2>", "."], "h": {"id": "C0025842", "name": "C0025842#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0154723", "name": "C0154723#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesized", "that", "C0378293#ent", "<e1>", "exerts", "antifibrotic", "effects", "binding", "to", "specific", "receptor", "sites", "cultured", "rat", "C0015674#ent", "<e2>", ",", "which", "mediate", "the", "inhibitory", "effects", "of", "C0378293#ent", "<e1>", "on", "ET-1-stimulated", "collagen", "synthesis"], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0378293", "name": "C0378293#ent", "pos": [3, 4]}}
{"token": ["Plasma", "C1439335#ent", "<e1>", "concentrations", "in", "the", "whole", "C0020473#ent", "<e2>", "population", "correlated", "negatively", "with", "triglycerides", "and", "positively", "with", "total", "cholesterol", "HDL-cholesterol", "and", "age", ",", "being", "unrelated", "to", "either", "body", "mass", "index", "lipid-lowering", "treatment", "."], "h": {"id": "C1439335", "name": "C1439335#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [7, 8]}}
{"token": ["Elevated", "serum", "levels", "of", "the", "atherogenic", "and", "thrombogenic", "lipoprotein", "(", "a", ")", "(", "C1439335#ent", "<e1>", "have", "been", "recognized", "as", "a", "feature", "of", "the", "nephrotic", "syndrome", "C0020473#ent", "<e2>", "."], "h": {"id": "C1439335", "name": "C1439335#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [25, 26]}}
{"token": ["A", "reduced", "H(+)", "secretory", "capacity", "of", "the", "proximal", "C0722058#ent", "<e1>", "also", "appears", "operative", "in", "two", "unrelated", "children", "with", "C0001126#ent", "<e2>", "Fanconi's", "syndrome", "and", "cystinosis", "."], "h": {"id": "C0722058", "name": "C0722058#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001126", "name": "C0001126#ent", "pos": [18, 19]}}
{"token": ["Overactivation", "of", "C4283740#ent", "<e1>", "inhibition", "of", "phosphoinositol-3", "kinase", "C0033634#ent", "<e2>", "to", "hyperphosphorylation", "of", "tau", "and", "impairment", "of", "spatial", "memory"], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [8, 9]}}
{"token": ["Overexpression", "of", "FrzA", "inhibited", "the", "increase", "in", "C4283740#ent", "<e1>", "phosphorylation", "as", "well", "as", "C0033634#ent", "<e2>", "PKC", ")", "epsilon", "activation", "in", "transgenic", "mice", "PC", "as", "compared", "with", "littermates", "."], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [13, 14]}}
{"token": ["Cells", "exposed", "to", "C1425440#ent", "<e1>", "or", "to", "C3538705#ent", "<e2>", "during", "growth", "inhibition", "DNA", "and", "protein", "synthesis", "24", "h", "upon", "removal", "of", "C1425440#ent", "<e1>", "or", "C3538705#ent", "<e2>", "from", "the", "culture", "medium"], "h": {"id": "C1425440", "name": "C1425440#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538705", "name": "C3538705#ent", "pos": [7, 8]}}
{"token": ["Atrial", "echo", "beats", "C0033036#ent", "<e1>", "in", "7", "of", "12", "patients", "treated", "with", "C0012702#ent", "<e2>", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0012702", "name": "C0012702#ent", "pos": [12, 13]}}
{"token": ["C0033036#ent", "<e1>", "atrial", "premature", "beats", "in", "7", "of", "12", "patients", "treated", "with", "C0012702#ent", "<e2>", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0012702", "name": "C0012702#ent", "pos": [12, 13]}}
{"token": ["Tumor", "necrosis", "factor-", "staurosporine-induced", "apoptosis", "of", "caspase-3-deficient", "MCF-7", "cells", "in", "cleavage", "of", "the", "death", "substrates", "PARP", ",", "Rb", ",", "PAK2", ",", "C1335262#ent", "<e1>", ",", "gelsolin", ",", "and", "C1413982#ent", "<e2>", ",", "but", "not", "alpha-fodrin", "."], "h": {"id": "C1335262", "name": "C1335262#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1413982", "name": "C1413982#ent", "pos": [27, 28]}}
{"token": ["These", "results", "suggest", "that", "C0950409#ent", "<e1>", "is", "more", "acceptable", "for", "the", "termination", "of", "early", "pregnancy", "is", "C0058310#ent", "<e2>", "."], "h": {"id": "C0950409", "name": "C0950409#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [16, 17]}}
{"token": ["In", "conscious", "rabbits", ",", "sequential", "inhibition", "of", "C0026815#ent", "<e1>", "and", "beta", "receptors", "produced", "and", "the", "relative", "contributions", "of", "C0042420#ent", "<e2>", "and", "sympathetic", "tone", "characterized", "."], "h": {"id": "C0026815", "name": "C0026815#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042420", "name": "C0042420#ent", "pos": [18, 19]}}
{"token": ["These", "results", "suggest", "that", "C1538756#ent", "<e1>", "encodes", "a", "precursor", "of", "proline", "dehydrogenase", "C0026454#ent", "<e2>", ")", ",", "which", "is", "regulated", "at", "the", "level", "of", "mRNA", "accumulation", "in", "both", "dehydrated", "and", "rehydrated", "plants", "."], "h": {"id": "C1538756", "name": "C1538756#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [12, 13]}}
{"token": ["C1421316#ent", "<e1>", "is", "the", "human", "homologue", "of", "the", "yeast", "ubiquitin", "fusion", "degradation", "1", "Ufd1", ")", "C0079429#ent", "<e2>", "and", "maps", "on", "chromosome", "22q11.2", "the", "typically", "deleted", "region", "(", "TDR", ")", "for", "DiGeorge/velocardiofacial", "syndromes", "DGS/VCFS", ")", "."], "h": {"id": "C1421316", "name": "C1421316#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["Two", "of", "the", "eight", "C0015625#ent", "<e1>", "genes", "have", "been", "cloned", "(", "C1414527#ent", "<e2>", "and", "FAC", ")", ",", "but", "their", "function", "has", "not", "yet", "been", "defined", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1414527", "name": "C1414527#ent", "pos": [11, 12]}}
{"token": ["Audiometric", "examinations", "were", "normal", "in", "the", "remaining", "597", "women", ",", "and", "repeated", "examinations", "revealed", "no", "new", "cases", "of", "C0029899#ent", "<e1>", "despite", "continuous", "C1412791#ent", "<e2>", "use", "."], "h": {"id": "C0029899", "name": "C0029899#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [22, 23]}}
{"token": ["Their", "effects", "are", "mediated", "through", "nuclear", "receptors", "Retinoic", "Acid", "Receptor", "C3538821#ent", "<e1>", ")", "and", "regulated", "by", "molecules", "such", "as", "C1419317#ent", "<e2>", "CRBP1", ")", "that", "function", "in", "retinol", "storage", "."], "h": {"id": "C3538821", "name": "C3538821#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419317", "name": "C1419317#ent", "pos": [19, 20]}}
{"token": ["Their", "effects", "are", "mediated", "through", "nuclear", "receptors", "Retinoic", "Acid", "Receptor", "C3538821#ent", "<e1>", ")", "and", "regulated", "by", "molecules", "such", "as", "Cellular", "Retinol-Binding", "Protein", "1", "C1419317#ent", "<e2>", ")", "that", "function", "in", "retinol", "storage", "."], "h": {"id": "C3538821", "name": "C3538821#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419317", "name": "C1419317#ent", "pos": [23, 24]}}
{"token": ["All", "patients", "could", "swallow", "without", "difficulty", "at", "the", "time", "of", "examination", "and", "had", "C0011168#ent", "<e1>", "regurgitation", ",", "heartburn", ",", "or", "sensation", "of", "C1291077#ent", "<e2>"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1291077", "name": "C1291077#ent", "pos": [22, 23]}}
{"token": ["Laparoscopic", "reoperations", "been", "performed", "between", "1996", "and", "2005", "for", "patients", "suffering", "recurrent", "reflux", "C0011168#ent", "<e1>", "or", "severe", "C1291077#ent", "<e2>", "symptomatic", "despite", "medical", "treatment"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1291077", "name": "C1291077#ent", "pos": [17, 18]}}
{"token": ["Transgenic", "mice", "overexpressing", "a", "mutated", "human", "gene", "(", "G93A", ")", "coding", "for", "the", "enzyme", "SOD1", "C0669516#ent", "<e1>", "develop", "a", "C0085084#ent", "<e2>", "ALS", "in", "humans", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [19, 20]}}
{"token": ["Metallothionein", "(", "MT", ")", "mRNA", "expression", "was", "investigated", "in", "a", "rodent", "model", "G93A", "C0669516#ent", "<e1>", "transgenic", "mouse", ")", "for", "a", "lethal", "C0085084#ent", "<e2>", "amyotrophic", "lateral", "sclerosis", "ALS", ")", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [21, 22]}}
{"token": ["Mice", "where", "a", "transgene", "has", "been", "incorporated", "that", "encodes", "for", "the", "human", "C0669516#ent", "<e1>", "mutation", "develop", "a", "form", "of", "C0085084#ent", "<e2>", "closely", "resembles", "human", "forms", "of", "this", "disease", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [19, 20]}}
{"token": ["C0010620#ent", "<e1>", "was", "compared", "with", "nifedipine", ",", "verapamil", "and", "C0282138#ent", "<e2>", "for", "calcium", "entry", "blocker", "activity", "in", "isolated", "cardiovascular", "preparations"], "h": {"id": "C0010620", "name": "C0010620#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [9, 10]}}
{"token": ["The", "structures", "of", "Sld5", "and", "C1825348#ent", "<e1>", "resemble", "those", "of", "C1704919#ent", "<e2>", "and", "Psf3", ",", "respectively", "."], "h": {"id": "C1825348", "name": "C1825348#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704919", "name": "C1704919#ent", "pos": [10, 11]}}
{"token": ["A", "combination", "of", "medical", "therapy-often", ",", "C0064113#ent", "<e1>", "or", "fluconazole-and", "surgical", "d\u00e9bridement", "is", "often", "needed", "to", "control", "C0009186#ent", "<e2>"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [17, 18]}}
{"token": ["We", "believe", "that", "C0064113#ent", "<e1>", "is", "an", "effective", "drug", "to", "treat", "C0009186#ent", "<e2>", "with", "a", "wide", "safety", "margin"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "-induced", "C1277259#ent", "<e1>", "may", "lead", "to", "the", "development", "of", "C0031046#ent", "<e2>", ",", "which", "is", "associated", "with", "occurrence", "of", "cardiac-type", "mucosa", "at", "the", "cardiac", "region"], "h": {"id": "C1277259", "name": "C1277259#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031046", "name": "C0031046#ent", "pos": [12, 13]}}
{"token": ["The", "decline", "of", "C1332036#ent", "<e1>", "mRNA", "expression", "observed", "in", "the", "normal", "C0669372#ent", "<e2>", "was", "enhanced", "by", "LPS", "treatment", ",", "but", "not", "in", "the", "Gd-hepatocytes", "."], "h": {"id": "C1332036", "name": "C1332036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [11, 12]}}
{"token": ["The", "pattern", "of", "axoplasmic", "disturbances", "in", "C0155300#ent", "<e1>", "secondary", "to", "intracranial", "pressure", "similar", "to", "that", "observed", "in", "C0155300#ent", "<e1>", "secondary", "to", "C0028841#ent", "<e1>", "increased", "intraocular", "pressure"], "h": {"id": "C0155300", "name": "C0155300#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028841", "name": "C0028841#ent", "pos": [21, 22]}}
{"token": ["C0025859#ent", "<e1>", "had", "no", "significant", "effect", "on", "the", "pharmacokinetics", "of", "bromazepam", "or", "C0024002#ent", "<e2>", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [12, 13]}}
{"token": ["We", "find", "that", "VPA", "and", "its", "analogs", "inhibit", "multiple", "C1422386#ent", "<e1>", "from", "class", "I", "class", "II", "but", "not", "HDAC6", "or", "C1425333#ent", "<e2>", ")", "with", "a", "characteristic", "order", "of", "potency", "in", "vitro"], "h": {"id": "C1422386", "name": "C1422386#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425333", "name": "C1425333#ent", "pos": [20, 21]}}
{"token": ["Another", "important", "addition", "is", "the", "inclusion", "of", "C0003205#ent", "<e1>", "and", "their", "target", "C0017337#ent", "<e2>", "that", "makes", "it", "possible", "to", "predict", "the", "compounds", ",", "that", "may", "interact", "with", "newly", "identified", "virulence", "factors"], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "C0084424#ent", "<e1>", "emodin", ",", "citrinin", ",", "and", "C0066415#ent", "<e2>", "obtained", "."], "h": {"id": "C0084424", "name": "C0084424#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0066415", "name": "C0066415#ent", "pos": [10, 11]}}
{"token": ["The", "marked", "difference", "in", "triglyceride", "levels", "between", "the", "treatment", "groups", "us", "to", "evaluate", "the", "lipoprotein", "lipase", "C1416867#ent", "<e1>", "activities", "in", "20", "C0020473#ent", "<e2>", ",", "nondiabetic", "patients", "."], "h": {"id": "C1416867", "name": "C1416867#ent", "pos": [16, 17]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [21, 22]}}
{"token": ["C1667052#ent", "<e1>", "is", "the", "first", "CCR5", "antagonist", "approved", "for", "treating", "C0019693#ent", "<e2>"], "h": {"id": "C1667052", "name": "C1667052#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [10, 11]}}
{"token": ["The", "most", "important", "proteins", "involved", "in", "the", "patient", "response", "a", "drug", "are", "cytochrome", "P450", "CYP", ")", "2D6", ",", "C3714749#ent", "<e1>", ",", "CYP3A4", "and", "the", "C1704939#ent", "<e2>"], "h": {"id": "C3714749", "name": "C3714749#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [24, 25]}}
{"token": ["Exposure", "of", "LPS-treated", "macrophages", "to", "IL10", "prior", "to", "co-culture", "prevented", "their", "ability", "to", "inhibit", "trophoblast", "invasion", "C1706247#ent", "<e1>", "expression", ",", "and", "to", "stimulate", "C1418252#ent", "<e2>", "secretion", "."], "h": {"id": "C1706247", "name": "C1706247#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418252", "name": "C1418252#ent", "pos": [23, 24]}}
{"token": ["A", "study", "on", "the", "C3658343#ent", "<e1>", "the", "stools", "of", "344", "infants", "and", "young", "children", "206", "C0152517#ent", "<e2>", "and", "138", "nondiarrhoeal", ")", "was", "carried", "out", "."], "h": {"id": "C3658343", "name": "C3658343#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0152517", "name": "C0152517#ent", "pos": [15, 16]}}
{"token": ["Signaling", "through", "either", "antigen", ",", "CD19", "or", "C1413240#ent", "<e1>", ",", "depended", "on", "C1421249#ent", "<e2>"], "h": {"id": "C1413240", "name": "C1413240#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [12, 13]}}
{"token": ["Sections", "were", "stained", "immunohistochemically", "for", "C0008407#ent", "<e1>", "ChAT", ")", "or", "p140trk", "(", "C1420874#ent", "<e2>", ")", "or", "histochemically", "for", "acetylcholinesterase", "(", "AChE", ")", "."], "h": {"id": "C0008407", "name": "C0008407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420874", "name": "C1420874#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "altered", "C3274824#ent", "<e1>", "and", "function", "correlate", "with", "many", "C0029896#ent", "<e2>", "."], "h": {"id": "C3274824", "name": "C3274824#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [10, 11]}}
{"token": ["An", "open-labeled", "study", "once-daily", "administration", "of", "40", "mg", "C0015620#ent", "<e1>", "was", "conducted", "in", "24", "patients", "with", "endoscopically", "confirmed", "C0014869#ent", "<e2>"], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0014869", "name": "C0014869#ent", "pos": [18, 19]}}
{"token": ["This", "hepatic", "failure", "perhaps", "the", "unusually", "severe", "C0042679#ent", "<e1>", "toxicity", "which", "gave", "rise", "to", "a", "C0032541#ent", "<e2>", "with", "important", "sequelae", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032541", "name": "C0032541#ent", "pos": [15, 16]}}
{"token": ["They", "have", "some", "things", "in", "common", ",", "and", "causes", "are", "considered", "arteriosclerosis", "or", "C1956391#ent", "<e1>", "old", "people", "and", "often", "takes", "place", "based", "on", "diabetes", "mellitus", "C0024141#ent", "<e2>", "another", "many", "diseases", "etiologically", "."], "h": {"id": "C1956391", "name": "C1956391#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [25, 26]}}
{"token": ["In", "addition", ",", "in", "LES", "circular", "muscle", "a", "low-molecular", "weight", "pancreatic-like", "phospholipase", "A2", "(", "group", "I", "C1418617#ent", "<e1>", ")", "causes", "production", "of", "AA", ",", "which", "is", "C0025517#ent", "<e2>", "to", "prostaglandins", "and", "thromboxanes", "."], "h": {"id": "C1418617", "name": "C1418617#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [26, 27]}}
{"token": ["The", "effect", "of", "three", "different", "C0242947#ent", "<e1>", "pirenzepine", ",", "biperiden", ",", "and", "C0041009#ent", "<e2>", "on", "memory", "consolidation", "investigated", "."], "h": {"id": "C0242947", "name": "C0242947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041009", "name": "C0041009#ent", "pos": [12, 13]}}
{"token": ["Pseudoephedrine", "is", "a", "C0042397#ent", "<e1>", "is", "contained", "in", "many", "C3815497#ent", "<e2>", "and", "cold", "medications"], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3815497", "name": "C3815497#ent", "pos": [9, 10]}}
{"token": ["We", "conclude", "that", "malY", "encodes", "an", "C0027203#ent", "<e1>", "that", "degrades", "the", "inducer", "of", "the", "C0024658#ent", "<e2>", "prevents", "its", "synthesis", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024658", "name": "C0024658#ent", "pos": [14, 15]}}
{"token": ["C0013504#ent", "<e1>", "AE", ")", "in", "humans", "is", "a", "C0008679#ent", "<e2>", "by", "slowly", "expanding", "liver", "lesions"], "h": {"id": "C0013504", "name": "C0013504#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [8, 9]}}
{"token": ["To", "investigate", "further", "the", "role", "of", "the", "A3AR", "gene", "in", "development", ",", "we", "overexpressed", "this", "gene", "in", "C1412251#ent", "<e1>", "knockout", "and", "wild-type", "mice", "by", "using", "the", "C3890000#ent", "<e2>", "promoter", "."], "h": {"id": "C1412251", "name": "C1412251#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3890000", "name": "C3890000#ent", "pos": [26, 27]}}
{"token": ["We", "observed", "that", "moderate", "copy", "number", "incorporation", "four", "copies", ")", "of", "the", "C1412251#ent", "<e1>", "gene", "driven", "by", "the", "C3890000#ent", "<e2>", "promoter", "is", "sufficient", "to", "induce", "lethality", "at", "an", "early", "stage", "embryo", "development"], "h": {"id": "C1412251", "name": "C1412251#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3890000", "name": "C3890000#ent", "pos": [18, 19]}}
{"token": ["Lung", "tissue", "C1968833#ent", "<e1>", "mRNA", "and", "C0027021#ent", "<e2>", "were", "obtained", "."], "h": {"id": "C1968833", "name": "C1968833#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [6, 7]}}
{"token": ["Urine", "cytology", "detected", "C0262655#ent", "<e1>", "crystaluria", ",", "dysplasia", "and", "atypia", ",", "squamous", "metaplasia", "transitional", "cell", "carcinoma", "C0076456#ent", "<e2>", ")", "."], "h": {"id": "C0262655", "name": "C0262655#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0076456", "name": "C0076456#ent", "pos": [16, 17]}}
{"token": ["At", "necropsy", "all", "five", "had", "normal", "sized", "hearts", "and", "in", "the", "four", "hearts", "examined", "by", "histology", "there", "was", "evidence", "of", "catecholamine", "induced", "C0018799#ent", "<e1>", "the", "form", "of", "C0027051#ent", "<e2>"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [27, 28]}}
{"token": ["C1418448#ent", "<e1>", "is", "a", "C3810600#ent", "<e2>", "binds", "to", "the", "C", "terminus", "of", "the", "high", "density", "lipoprotein", "receptor", "scavenger", "receptor", "class", "B", "type", "I", "SR-BI", ")", ",", "and", "controls", "the", "posttranscriptional", ",", "tissue-specific", "expression", "of", "this", "lipoprotein", "receptor"], "h": {"id": "C1418448", "name": "C1418448#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3810600", "name": "C3810600#ent", "pos": [4, 5]}}
{"token": ["C1333203#ent", "<e1>", "FADD", ")", "is", "an", "adaptor", "molecule", "links", "death", "receptors", "C0667830#ent", "<e2>", "in", "many", "cell", "types", "cardiomyocytes", "(", "CMs", ")", "."], "h": {"id": "C1333203", "name": "C1333203#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0667830", "name": "C0667830#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "propose", "that", "SADS", "is", "one", "of", "the", "C1333203#ent", "<e1>", "enhances", "Fas-DISC", "formation", ",", "especially", "FADD", "and", "C0667830#ent", "<e2>", "recruitment", "."], "h": {"id": "C1333203", "name": "C1333203#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0667830", "name": "C0667830#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "role", "of", "hematopietic", "progenitor", "kinase", "1", "(", "C4085189#ent", "<e1>", ")", "in", "delayed", "neuronal", "damage", "C0007785#ent", "<e2>", "the", "possible", "regulatory", "mechanisms", "this", "event", "."], "h": {"id": "C4085189", "name": "C4085189#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [21, 22]}}
{"token": ["Since", "then", "CEA", "activity", "in", "C0149741#ent", "<e1>", "estimated", "in", "60", "patients", "with", "C0006145#ent", "<e2>", "means", "of", "enzyme", "immunoassay", "monoclonal", "anti", "CEA", "antibody"], "h": {"id": "C0149741", "name": "C0149741#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006145", "name": "C0006145#ent", "pos": [12, 13]}}
{"token": ["Although", "cystic", "fibrosis", "a", "multisystem", "disorder", "C0024115#ent", "<e1>", "the", "main", "cause", "of", "morbidity", "and", "C1145670#ent", "<e2>", "the", "main", "cause", "of", "death", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [14, 15]}}
{"token": ["Mutations", "that", "identify", "an", "C0014230#ent", "<e1>", "to", "that", "found", "at", "the", "active", "site", "type", "II", "restriction", "C3541394#ent", "<e2>", "and", "other", "nucleases", "have", "been", "shown", "to", "abolish", "DNA", "nicking", "activity"], "h": {"id": "C0014230", "name": "C0014230#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["Percutaneous", "cholecystostomy", "a", "valuable", "alternative", "temporary", "measure", "for", "C0149520#ent", "<e1>", "elderly", "patients", "with", "severe", "underlying", "C0034072#ent", "<e2>", "but", "the", "subsequent", "management", "of", "gallbladder", "calculi", "still", "controversial", "."], "h": {"id": "C0149520", "name": "C0149520#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [15, 16]}}
{"token": ["However", ",", "many", "questions", "remain", "as", "to", "the", "mechanism", "by", "which", "this", "operation", "prevents", "C0017168#ent", "<e1>", "in", "those", "without", "C3489393#ent", "<e2>", "incompetent", "lower", "esophageal", "sphincters", "LES", ")", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C3489393", "name": "C3489393#ent", "pos": [19, 20]}}
{"token": ["The", "extract", "from", "rat", "liver", "chromatin", "two", "apurinic/apyrimidinic", "(AP)", "C0014143#ent", "<e1>", "named", "0.2", "M", "and", "0.3", "M", "C0026794#ent", "<e2>", "according", "to", "the", "phosphate", "concentration", "necessary", "to", "elute", "them", "from", "an", "hydroxyapatite", "column"], "h": {"id": "C0014143", "name": "C0014143#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026794", "name": "C0026794#ent", "pos": [17, 18]}}
{"token": ["Results", "indicate", "that", "C1510471#ent", "<e1>", "existed", "particularly", "for", "C2936883#ent", "<e2>", "vitamin", "B6", "vitamin", "A."], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936883", "name": "C2936883#ent", "pos": [8, 9]}}
{"token": ["No", "specific", "psychiatric", "syndrome", "connected", "with", "C1510471#ent", "<e1>", "but", "a", "preponderance", "of", "arteriosclerotic", "dementia", "that", "low", "serum", "C2936883#ent", "<e2>", "values", "are", "secondary", "to", "mental", "illness", "to", "apathy", "and", "loss", "of", "appetite"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936883", "name": "C2936883#ent", "pos": [17, 18]}}
{"token": ["To", "assess", "the", "relationship", "between", "seizure", "control", "C0242898#ent", "<e1>", "GABA", ")", ",", "homocarnosine", ",", "and", "C0072780#ent", "<e2>", "the", "visual", "cortex", "patients", "with", "epilepsy", "taking", "valproate", "or", "lamotrigine", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072780", "name": "C0072780#ent", "pos": [15, 16]}}
{"token": ["Eighty", "micrograms", "of", "C1412244#ent", "<e1>", "was", "released", "from", "the", "C0001275#ent", "<e2>", "reversibly", ",", "and", "the", "biological", "activity", "C1412244#ent", "<e1>", "released", "from", "the", "C0001275#ent", "<e2>", "was", "retained", "perfectly", "."], "h": {"id": "C0001275", "name": "C0001275#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412244", "name": "C1412244#ent", "pos": [3, 4]}}
{"token": ["Entopeduncolar", "or", "nigral", "injection", "of", "C0022471#ent", "<e1>", "an", "early", "decrease", "of", "the", "evoked", "amygdaloid", "C0235480#ent", "<e2>", "a", "later", "increase", "of", "the", "after", "discharge", "duration"], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [14, 15]}}
{"token": ["Our", "data", "suggest", "that", "C1826567#ent", "<e1>", "is", "a", "potential", "C0029016#ent", "<e2>", ",", "that", "its", "expression", "is", "deregulated", "during", "cancer", "progression", "and", "that", "C1826567#ent", "<e1>", "may", "play", "a", "role", "in", "oncogenesis", "."], "h": {"id": "C1826567", "name": "C1826567#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [9, 10]}}
{"token": ["Additionally", ",", "there", "is", "substantial", "knowledge", "of", "the", "pharmacodynamics", "and", "kinetics", "of", "C0003299#ent", "<e1>", "and", "some", "candidate", "C1417679#ent", "<e2>", "implicated", "in", "the", "disorder", "have", "been", "identified", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["All", "the", "effects", "of", "C0023992#ent", "<e1>", "were", "mimicked", "by", "C0040979#ent", "<e2>", ",", "a", "calmodulin", "antagonist"], "h": {"id": "C0023992", "name": "C0023992#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [9, 10]}}
{"token": ["Another", "important", "finding", "that", "confirmed", "the", "pathological", "significance", "of", "TNFalpha", "was", "that", "mice", "C1516876#ent", "<e1>", "engineered", "to", "overexpress", "TNFalpha", "spontaneously", "developed", "C0003864#ent", "<e2>", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [21, 22]}}
{"token": ["Classic", "rheumatoid", "nodules", "occur", "in", "C1516876#ent", "<e1>", "predisposed", "patients", "with", "severe", ",", "C0003864#ent", "<e2>"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [12, 13]}}
{"token": ["It", "is", "well-known", "that", "subjects", "with", "diabetes", "resulting", "from", "C0238339#ent", "<e1>", "prone", "to", "diabetic", "microvascular", "complications", "C0021847#ent", "<e2>", ",", "nephropathy", "and", "retinopathy", ")", "."], "h": {"id": "C0238339", "name": "C0238339#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [16, 17]}}
{"token": ["LY294002", "cell", "preincubation", "did", "not", "affect", "GAB2", ",", "SHC", "and", "C1706044#ent", "<e1>", "tyrosine", "phosphorylation", "inhibited", "the", "binding", "of", "C0136864#ent", "<e2>", "to", "GAB2", "and", "C1706044#ent", "<e1>", "."], "h": {"id": "C0136864", "name": "C0136864#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [10, 11]}}
{"token": ["Epistatic", "interactions", "the", "C1420449#ent", "<e1>", "EAG", "susceptibility", "gene", "the", "C0919509#ent", "<e2>", "were", "also", "identified", ",", "and", "the", "presence", "of", "an", "H2-linked", "susceptibility", "gene", "(", "Gasa4", ")", "confirmed", "by", "analysis", "of", "H2", "congenic", "mice"], "h": {"id": "C1420449", "name": "C1420449#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "elevated", "serum", "silicon", "concentrations", "may", "help", "to", "alleviate", "aluminium", "toxicity", "C2316810#ent", "<e1>", "assist", "in", "the", "rapid", "clearance", "of", "C0051510#ent", "<e2>", "seen", "after", "kidney", "transplantation"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0051510", "name": "C0051510#ent", "pos": [20, 21]}}
{"token": ["Desferrioxamine", "(", "DFO", ")", "has", "been", "suggested", "to", "improve", "erythropoiesis", "in", "C2316810#ent", "<e1>", "of", "its", "C0051510#ent", "<e2>", "(Al)-chelating", "effect", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0051510", "name": "C0051510#ent", "pos": [15, 16]}}
{"token": ["A", "77", "G", "allele", "the", "gene", "encoding", "CD45", ",", "also", "known", "as", "the", "C1870006#ent", "<e1>", "PTPRC", ")", ",", "has", "been", "associated", "with", "C0026769#ent", "<e2>", "MS", ")", "."], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [13, 14]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [22, 23]}}
{"token": ["A", "point", "mutation", "in", "protein", "tyrosine", "phosphatase", "receptor", "type", "c", "polypeptide", "C1870006#ent", "<e1>", ")", "has", "been", "associated", "with", "C0026769#ent", "<e2>"], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [11, 12]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "I3C", "abrogated", "C1367721#ent", "<e1>", "activation", "of", "C0164786#ent", "<e2>", "in", "PC-3", "cells"], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [9, 10]}}
{"token": ["After", "remission", "of", "the", "C0027726#ent", "<e1>", "the", "plasma", "C1439335#ent", "<e2>", "level", "decreased", "to", "204", "mg/dl", "and", "the", "total", "cholesterol", "decreased", "to", "179", "mg/dl", ",", "while", "very", "high", "levels", "of", "C1439335#ent", "<e2>", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1439335", "name": "C1439335#ent", "pos": [8, 9]}}
{"token": ["Patients", "with", "C0027726#ent", "<e1>", "the", "highest", "C1439335#ent", "<e2>", "Lp(a)", "concentrations", "known", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1439335", "name": "C1439335#ent", "pos": [6, 7]}}
{"token": ["C1367455#ent", "<e1>", "B", "from", "Cad", "erythrocyte", "membranes", "the", "carriers", "of", "the", "blood", "group", "C0010068#ent", "<e2>", "determinants", "."], "h": {"id": "C1367455", "name": "C1367455#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [13, 14]}}
{"token": ["Inhibition", "specificity", "the", "enzyme", "is", "characteristic", "of", "serine", "proteinases", "more", "like", "that", "of", "C0041236#ent", "<e1>", "that", "of", "the", "major", "CSP", "C0022173#ent", "<e2>", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [20, 21]}}
{"token": ["The", "influence", "of", "a", "partial", "proteolysis", "by", "C0041236#ent", "<e1>", "on", "the", "subunit", "structure", "the", "C0022173#ent", "<e2>", "pattern", "and", "the", "kinetic", "characteristics", "of", "red", "cell", "liver", "enzyme", "been", "investigated", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [14, 15]}}
{"token": ["Different", "diagnoses", "of", "MD", "are", "included", ":", "C0027126#ent", "<e1>", "myopathia", "distalis", "tarda", "hereditaria", "Becker", "MD", ",", "facioscapulohumeral", "MD", "C0686353#ent", "<e2>", "Emery-Dreifuss", "and", "undetermined", "proximal", "MD", "Duchenne", "MD", "is", "not", "included", ")", "."], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [18, 19]}}
{"token": ["Microinjections", "of", "the", "C0243046#ent", "<e1>", "L-homocysteic", "acid", "DLH", ")", "in", "both", "rostral", "and", "caudal", "dorsal", "periaqueductal", "gray", "matter", "C1705981#ent", "<e2>", ")", "caused", "explosive", "motor", "behaviour", "of", "defence", "."], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705981", "name": "C1705981#ent", "pos": [18, 19]}}
{"token": ["The", "presence", "of", "all", "subtypes", "of", "C0243046#ent", "<e1>", "binding", "sites", "in", "the", "C1705981#ent", "<e2>", "suggests", "that", "C0243046#ent", "<e1>", "action", "within", "the", "C1705981#ent", "<e2>", "is", "likely", "to", "be", "complex", "."], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705981", "name": "C1705981#ent", "pos": [12, 13]}}
{"token": ["However", ",", "BMIPP/Tl", "in", "SHR-H", "(", "0.53+/-0.09", ")", "was", "similar", "to", "that", "in", "SHR-N.", "These", "results", "suggest", "that", "C0006938#ent", "<e1>", "improves", "fatty", "acid", "metabolism", "in", "the", "C0149721#ent", "<e2>", "SHR", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [18, 19]}, "relation": "may_prevent", "t": {"id": "C0149721", "name": "C0149721#ent", "pos": [26, 27]}}
{"token": ["Changes", "in", "pH", "and", "temperature", "during", "C0085593#ent", "<e1>", "were", "observed", "and", ",", "after", "C0085593#ent", "<e1>", ",", "quality", "assessments", "C1705360#ent", "<e1>", "and", "Sm", "muscles", "drip", "loss", ",", "muscle", "opacity", "instrumental", "toughness", "at", "3", "days", "post-slaughter", "."], "h": {"id": "C0085593", "name": "C0085593#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [18, 19]}}
{"token": ["The", "presence", "of", "the", "RN(-", ")", "allele", "and", "a", "slow", "C0085593#ent", "<e1>", "regime", "increased", "the", "rate", "of", "pH", "decline", "in", "C1705360#ent", "<e2>", "."], "h": {"id": "C0085593", "name": "C0085593#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [20, 21]}}
{"token": ["At", "both", "C0085593#ent", "<e1>", "temperatures", "WBSF", "values", "were", "lower", "in", "ES", "hot-boned", "C1705360#ent", "<e2>", "and", "SM", "muscles", "at", "days", "2", ",", "7", "and", "14", "post-mortem", "than", "NES", "muscles", "."], "h": {"id": "C0085593", "name": "C0085593#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [12, 13]}}
{"token": ["No", "previous", "study", "has", "tested", "helium", "in", "combination", "with", "C0074414#ent", "<e1>", "a", "clinically", "useful", "combination", "especially", "in", "anaesthesia", "for", "C0001883#ent", "<e2>"], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [19, 20]}}
{"token": ["We", "report", "the", "experience", "with", "a", "procedure", "based", "on", "C0074414#ent", "<e1>", "inhalation", "via", "a", "nasopharyngeal", "airway", "early", "during", "induction", "before", "C0001883#ent", "<e2>", "."], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [20, 21]}}
{"token": ["We", "observed", "that", "C1639494#ent", "<e1>", "was", "a", "much", "better", "inhibitor", "of", "the", "C1414438#ent", "<e2>", "EPO", ")", "in", "an", "assay", "that", "measured", "peroxidase-catalyzed", "oxidation", "of", "tetramethylbenzidine", "at", "pH", "5.4", "."], "h": {"id": "C1639494", "name": "C1639494#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [12, 13]}}
{"token": ["C0035179#ent", "<e1>", "a", "derivative", "of", "the", "antihypertensive", "drug", "C0035179#ent", "<e1>", ",", "inhibits", "catecholamine", "transport", "adrenal", "medullary", "chromaffin", "vesicles", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [0, 1]}}
{"token": ["Because", "C0035179#ent", "<e1>", "much", "more", "polar", "than", "C0035179#ent", "<e1>", ",", "it", "does", "not", "permeate", "the", "chromaffin", "vesicle", "membrane", ",", "nor", "is", "it", "transported", "into", "chromaffin", "vesicle", "ghosts", "in", "the", "presence", "of", "Mg2+-ATP"], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [1, 2]}}
{"token": ["Thus", ",", "humans", "have", "retained", "an", "C1970411#ent", "<e1>", "encodes", "a", "functional", ",", "but", "poorly", "expressed", ",", "C0010723#ent", "<e2>", "no", "apparent", "antiviral", "activity"], "h": {"id": "C1970411", "name": "C1970411#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010723", "name": "C0010723#ent", "pos": [16, 17]}}
{"token": ["Limited", "proteolytic", "fragmentation", "the", "C1334335#ent", "<e1>", "component", "of", "several", "serologically", "distinct", "EIAV", "C1875400#ent", "<e2>", "produced", "common", "12", "K", "immunoreactive", "fragments", "that", "contained", "a", "conserved", "epitope", "."], "h": {"id": "C1334335", "name": "C1334335#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}}
{"token": ["We", "also", "compare", "the", "C1417239#ent", "<e1>", "null", "phenotype", "with", "the", "Fanconi", "anemia", "phenotype", ",", "a", "C0012634#ent", "<e2>", "by", "cellular", "hypersensitivity", "DNA", "cross-linking", "agents", "including", "MMC", "."], "h": {"id": "C1417239", "name": "C1417239#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["Among", "the", "C0009326#ent", "<e1>", "systemic", "lupus", "erythematosus", "SLE", ")", "reveals", "the", "highest", "frequency", "of", "C2828177#ent", "<e2>"], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2828177", "name": "C2828177#ent", "pos": [14, 15]}}
{"token": ["Amino", "acid", "analysis", "the", "isolated", "C0599220#ent", "<e1>", "revealed", "that", "subunit", "III", "a", "mitochondrial", "translation", "product", "contained", "41.9", "%", "C0815038#ent", "<e2>", "whereas", "subunits", "V", "VII", ",", "cytoplasmic", "translation", "products", "each", "contained", "47.7", "%", "C0815038#ent", "<e2>"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0815038", "name": "C0815038#ent", "pos": [18, 19]}}
{"token": ["Further", "characterization", "of", "this", "process", "with", "C3539583#ent", "<e1>", "described", ",", "and", "the", "range", "of", "C0007158#ent", "<e2>", "engaging", "in", "this", "behavior", "is", "examined", "."], "h": {"id": "C3539583", "name": "C3539583#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007158", "name": "C0007158#ent", "pos": [14, 15]}}
{"token": ["C3539583#ent", "<e1>", "activities", "present", "in", "the", "human", "colonic", "microbiota", "on", "C0007158#ent", "<e2>", "compounds", "and", "xenobiotics", "entering", "the", "colon", ",", "with", "potential", "health", "implications", "for", "the", "human", "host", "."], "h": {"id": "C3539583", "name": "C3539583#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007158", "name": "C0007158#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "anionic", "drugs", "as", "phenylbutazone", ",", "warfarin", "and", "salicylate", "do", "not", "displace", "glyburide", "from", "C1412332#ent", "<e1>", "as", "they", "displace", "C0040374#ent", "<e2>", "and", "chlorpropamide", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [20, 21]}}
{"token": ["Results", "of", "multiple", "linear", "regression", "analysis", "that", ",", "although", "age", "had", "a", "considerably", "greater", "influence", "than", "C1412332#ent", "<e1>", "concentration", ",", "total", "C0040374#ent", "<e2>", "concentration", "was", "the", "most", "important", "determinant", "of", "the", "unbound", "fraction", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [21, 22]}}
{"token": ["These", "include", "dermatological", "adverse", "effects", "as", "psoriasis", ",", "pemphigus", "and", "vitiligo", ",", "and", "also", "rare", "cases", "of", "sarcoidosis", ",", "C0019158#ent", "<e1>", ",", "colitis", "or", "C0010403#ent", "<e2>", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010403", "name": "C0010403#ent", "pos": [24, 25]}}
{"token": ["The", "patient", "also", "developed", "vasculitis", ",", "C0019158#ent", "<e1>", ",", "pleuritis", ",", "pericarditis", ",", "C0010403#ent", "<e2>", ",", "and", "disseminated", "intra-vascular", "coagulopathy", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010403", "name": "C0010403#ent", "pos": [13, 14]}}
{"token": ["Noninvasive", "ventilation", "been", "shown", "to", "be", "effective", "in", "patients", "with", "acute", "respiratory", "failure", "to", "C0034063#ent", "<e1>", "exacerbations", "of", "C3714496#ent", "<e2>", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3714496", "name": "C3714496#ent", "pos": [18, 19]}}
{"token": ["The", "activities", "of", "ADH", ",", "alphaGPDH", ",", "C2697821#ent", "<e1>", "and", "6PGDH", "were", "determined", "on", "C0054259#ent", "<e2>", "gel", "after", "electrophoresis", "in", "10", "F1", "females", "of", "each", "of", "the", "35", "isofemale", "lines", "."], "h": {"id": "C2697821", "name": "C2697821#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [14, 15]}}
{"token": ["The", "C3540471#ent", "<e1>", "was", "to", "investigate", "the", "C0020616#ent", "<e2>", "and", "anti-oxidant", "activities", "of", "the", "dried", "roots", "Morinda", "officinalis", "streptozotocin-induced", "diabetic", "rats", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [7, 8]}}
{"token": ["In", "the", "control", "subjects", "serum", "concentration", "of", "1,25[OH]2D", "increased", "after", "the", "C1430988#ent", "<e1>", "infusion", ",", "whereas", "there", "was", "no", "response", "the", "patient", "with", "C0221468#ent", "<e2>"], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0221468", "name": "C0221468#ent", "pos": [23, 24]}}
{"token": ["Therefore", ",", "it", "is", "recommended", "that", "a", "course", "of", "C3540778#ent", "<e1>", "be", "instituted", "concomitantly", "with", "radioiodine", "therapy", "or", "thyroidectomy", "in", "C0018213#ent", "<e2>", "'", "patients", "with", "some", "degree", "of", "ocular", "involvement", "."], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018213", "name": "C0018213#ent", "pos": [20, 21]}}
{"token": ["We", "characterized", "two", "Trypanosoma", "cruzi", "proteins", "C1512488#ent", "<e1>", "to", "mammalian", "C3853653#ent", "<e2>", "TcPolbeta", "and", "TcPolbetaPAK", ",", "and", "showed", "that", "both", "enzymes", "localize", "to", "the", "parasite", "kinetoplast", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3853653", "name": "C3853653#ent", "pos": [10, 11]}}
{"token": ["However", ",", "other", "C3850109#ent", "<e1>", "galantamine", "and", "tacrine", ")", "and", "NMDA", "receptor", "antagonists", "C0025242#ent", "<e2>", "and", "dizocilpine", "(", "MK801", ")", ")", "did", "not", "significantly", "decrease", "LDH", "release", "."], "h": {"id": "C3850109", "name": "C3850109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025242", "name": "C0025242#ent", "pos": [13, 14]}}
{"token": ["To", "investigate", "the", "occurrence", "of", "C0085543#ent", "<e1>", "seizure", "clusters", ",", "and", "the", "C0720099#ent", "<e2>", "until", "first", "seizure", "at", "epilepsy", "monitoring", "units", "in", "the", "United", "States"], "h": {"id": "C0085543", "name": "C0085543#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [12, 13]}}
{"token": ["We", "report", "the", "MR", "imaging", "findings", "in", "a", "20", "year", "old", "woman", "with", "C0085543#ent", "<e1>", "more", "than", "3", "months", "C0720099#ent", "<e2>", "following", "an", "episode", "of", "lymphocytic", "meningitis"], "h": {"id": "C0085543", "name": "C0085543#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [19, 20]}}
{"token": ["Pheochromocytoma", "is", "a", "tumor", "that", "may", "occur", "sporadically", "or", "may", "be", "a", "manifestation", "of", "a", "C0015398#ent", "<e1>", "such", "as", "von", "Hippel-Lindau", "disease", "C0019562#ent", "<e2>", ")", "and", "multiple", "endocrine", "neoplasia", "MEN", ")", "type", "2", "."], "h": {"id": "C0015398", "name": "C0015398#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [22, 23]}}
{"token": ["Ideally", ",", "such", "a", "model", "should", "rapidly", "determine", "the", "effectiveness", "of", "C0035064#ent", "<e1>", "that", "inhibit", "the", "damaging", "effects", "this", "C1848862#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [19, 20]}}
{"token": ["Studies", "in", "animals", ",", "involving", "the", "infusion", "of", "endotoxin", ",", "have", "produced", "convincing", "evidence", "that", "these", "C0035064#ent", "<e1>", "can", "cause", "pulmonary", "vascular", "injury", "a", "C1848862#ent", "<e2>", "resembling", "human", "ARDS", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [24, 25]}}
{"token": ["From", "this", "perspective", ",", "ECT", "may", "share", "similar", "mechanisms", "of", "action", "with", "other", "C0035064#ent", "<e1>", "that", "are", "also", "effective", "in", "treating", "the", "specific", "C1848862#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [23, 24]}}
{"token": ["DL-ethionine", "(", "C0001716#ent", "<e1>", ")", ",", "cerulein", "(", "Cd", ")", ",", "seleno-DL-methionine", "(", "C1517683#ent", "<e2>", ")", "and", "seleno-DL-ethionine", "(", "SeAet", ")", "were", "given", "to", "rats", "during", "various", "time", "periods"], "h": {"id": "C0001716", "name": "C0001716#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1517683", "name": "C1517683#ent", "pos": [13, 14]}}
{"token": ["Chimeric", "mutants", "Cdk2", "and", "C0694873#ent", "<e1>", ",", "which", "differ", "sharply", "in", "their", "affinities", "toward", "C1332722#ent", "<e2>", ",", "show", "that", "their", "C-terminal", "portions", "determine", "this", "difference", "."], "h": {"id": "C0694873", "name": "C0694873#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332722", "name": "C1332722#ent", "pos": [14, 15]}}
{"token": ["A", "physical", "interaction", "C1332722#ent", "<e1>", "and", "C0694873#ent", "<e2>", "suggests", "that", "C1332722#ent", "<e1>", "may", "regulate", "the", "mammalian", "cell", "cycle", "a", "direct", "effect", "on", "C0694873#ent", "<e2>", "."], "h": {"id": "C0694873", "name": "C0694873#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332722", "name": "C1332722#ent", "pos": [3, 4]}}
{"token": ["Although", "asterixis", ",", "dystonia", ",", "and", "tremor", "have", "been", "described", "with", "C0006949#ent", "<e1>", "(", "Tegretol", ")", ",", "there", "is", "no", "report", "of", "C0152115#ent", "<e2>"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0152115", "name": "C0152115#ent", "pos": [22, 23]}}
{"token": ["The", "generation", "of", "Ang-(1", "-", "7", ")", "is", "under", "the", "control", "of", "at", "least", "three", "C3541394#ent", "<e1>", ",", "which", "include", "neprilysin", ",", "C0145620#ent", "<e2>", "and", "prolyl", "oligopeptidase", "on", "the", "tissue", "compartment"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0145620", "name": "C0145620#ent", "pos": [22, 23]}}
{"token": ["The", "results", "suggest", "that", "the", "isolated", "bioactive", "peptides", "act", "on", "conversion", "and/or", "inactivation", "of", "endogenous", "peptides", "by", "C3541394#ent", "<e1>", "such", "as", "angiotensin-converting", "enzyme", "C0145620#ent", "<e2>", "modifying", "several", "systemic", "responses", "as", "blood-pressure", "regulation", "in", "pain", "response"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0145620", "name": "C0145620#ent", "pos": [23, 24]}}
{"token": ["The", "three", "C0599220#ent", "<e1>", "of", "this", "holotoxin", ",", "CdtA", ",", "C1413251#ent", "<e2>", ",", "and", "CdtC", ",", "and", "three", "C1413251#ent", "<e2>", "mutants", "were", "produced", "as", "recombinant", "histidine-tagged", "proteins", "by", "using", "an", "in", "vitro", "cell-free", "protein", "expression", "system"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413251", "name": "C1413251#ent", "pos": [10, 11]}}
{"token": ["In", "transient", "transfection", "reporter", "gene", "assays", ",", "C1427956#ent", "<e1>", "functions", "as", "a", "transcriptional", "coactivator", "NF-kappaB", "and", "cooperates", "with", "C1337090#ent", "<e2>", "and", "P/CAF", "to", "enhance", "TNFalpha-induced", "NF-kappaB", "activity"], "h": {"id": "C1427956", "name": "C1427956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337090", "name": "C1337090#ent", "pos": [18, 19]}}
{"token": ["Our", "results", "suggest", "that", "plants", "have", "evolved", "one", "network", "to", "adjust", "C1412379#ent", "<e1>", "activity", "through", "their", "5", "'", "leader", "sequences", "through", "which", "C1710463#ent", "<e2>", "combined", "with", "an", "extensive", "posttranscriptional", "control", "circuit", "."], "h": {"id": "C1412379", "name": "C1412379#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [22, 23]}}
{"token": ["Consequently", ",", "we", "examined", "the", "effects", "of", "C0114873#ent", "<e1>", "on", "human", "bladder", "smooth", "muscle", "cell", "C3888088#ent", "<e2>", ")", "proliferation", "and", "apoptosis", "."], "h": {"id": "C0114873", "name": "C0114873#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [15, 16]}}
{"token": ["By", "contrast", "with", "ketanserin", ",", "LY53857", "and", "1-NP", ",", "the", "peripherally-acting", "5-HT2", "antagonist", "C0033321#ent", "<e1>", "failed", "to", "alter", "the", "C0003123#ent", "<e2>", "DOI", "."], "h": {"id": "C0033321", "name": "C0033321#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003123", "name": "C0003123#ent", "pos": [19, 20]}}
{"token": ["Although", "they", "lack", "ACA", ",", "which", "has", "a", "transporter-like", "structure", ",", "the", "cells", "expressing", "C0050397#ent", "<e1>", "secrete", "cAMP", "C0669365#ent", "<e2>", "."], "h": {"id": "C0050397", "name": "C0050397#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [18, 19]}}
{"token": ["C0009325#ent", "<e1>", "abundance", ",", "as", "well", "as", "C1414313#ent", "<e2>", "EGFR", ")", "expression", "and", "ERK1/2", "phosphorylation", ",", "was", "investigated", "by", "ELISA", "and", "Western", "blot"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [7, 8]}}
{"token": ["C0026847#ent", "<e1>", "spans", "from", "severe", "C0043116#ent", "<e2>", "C0026847#ent", "<e1>", "1", ")", "to", "relatively", "benign", "Kugelberg-Welander", "disease", "C0026847#ent", "<e1>", "3", ")", "."], "h": {"id": "C0043116", "name": "C0043116#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [0, 1]}}
{"token": ["However", ",", "selectivity", "was", "generally", "poor", "when", "compared", "to", "other", "PTPases", "such", "as", "C1705637#ent", "<e1>", ",", "SHP-2", ",", "and", "especially", "C0252270#ent", "<e2>", ",", "for", "which", "almost", "no", "selectivity", "was", "found", "."], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0252270", "name": "C0252270#ent", "pos": [20, 21]}}
{"token": ["The", "levels", "of", "C1413043#ent", "<e1>", "C", "isozymes", "human", "red", "cells", "determined", "using", "a", "quantitative", "immunological", "technique", "patients", "with", "C0024117#ent", "<e2>"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [18, 19]}}
{"token": ["We", "report", "here", "the", "isolation", "and", "regional", "mapping", "a", "human", "gene", "TDPX1", ",", "that", "encodes", "an", "C0014442#ent", "<e1>", "homologous", "to", "a", "yeast", "thioredoxin-dependent", "peroxide", "reductase", "C1137156#ent", "<e2>", "TPX", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1137156", "name": "C1137156#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "it", "is", "concluded", "that", "C1565860#ent", "<e1>", "selective", "inhibitors", "be", "promising", "C0035064#ent", "<e2>", "for", "prevention", "and", "treatment", "of", "cancer", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [12, 13]}}
{"token": ["Two", "isozymes", "of", "the", "COX", "enzyme", "have", "been", "reported", ",", "COX-1", "and", "C1565860#ent", "<e1>", ",", "but", "the", "C0035064#ent", "<e2>", "thus", "far", "examined", "are", "not", "isozyme", "selective", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}}
{"token": ["Non-steroidal", "anti-inflammatory", "drugs", "NSAIDs", ")", "including", "cyclooxygenase", "2", "C1565860#ent", "<e1>", ")", "selective", "inhibitors", ",", "are", "potential", "C0035064#ent", "<e2>", "for", "the", "chemoprevention", "of", "gastric", "cancer"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [16, 17]}}
{"token": ["The", "clinical", "presentations", "C0016399#ent", "<e1>", "similar", "to", "the", "syndromes", "of", "C0391957#ent", "<e2>", "most", "cases", "."], "h": {"id": "C0016399", "name": "C0016399#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0391957", "name": "C0391957#ent", "pos": [10, 11]}}
{"token": ["C0354872#ent", "<e1>", "(", "CPH", ")", "and", "C1517662#ent", "<e2>", "(", "KTS", ")", "which", "are", "S2-serotonergic", "antagonists", "also", "effective", "on", "the", "reduction", "of", "mortality", "."], "h": {"id": "C0354872", "name": "C0354872#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [6, 7]}}
{"token": ["The", "5-HT2", "antagonists", "C0354872#ent", "<e1>", ",", "cinanserin", ",", "ritanserin", ",", "and", "C1517662#ent", "<e2>", "increased", "the", "rate", "of", "tactile", "startle", "habituation", "affecting", "initial", "levels", "of", "reactivity", "."], "h": {"id": "C0354872", "name": "C0354872#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [11, 12]}}
{"token": ["The", "C0010406#ent", "<e1>", "were", "sucrose", ",", "dsorbitol", ",", "C0065601#ent", "<e2>", "DE", "24", "-", "38", "and", "synthetic", "polydextrose", "."], "h": {"id": "C0010406", "name": "C0010406#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0065601", "name": "C0065601#ent", "pos": [8, 9]}}
{"token": ["C0220989#ent", "<e1>", "known", "to", "be", "associated", "with", "C0017662#ent", "<e2>"], "h": {"id": "C0220989", "name": "C0220989#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017662", "name": "C0017662#ent", "pos": [7, 8]}}
{"token": ["Mutations", "in", "the", "C1334896#ent", "<e1>", "NR0B2", ";", "alias", "SHP", ")", "are", "associated", "with", "high", "birth", "weight", "C0028754#ent", "<e2>", "Japanese", "children", "."], "h": {"id": "C1334896", "name": "C1334896#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [16, 17]}}
{"token": ["All", "C1826396#ent", "<e1>", ",", "both", "moving", "and", "stationary", ",", "contained", "NFL", ",", "C2981621#ent", "<e2>", ",", "peripherin", "and", "alpha-internexin", "along>85", "%", "of", "their", "length", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2981621", "name": "C2981621#ent", "pos": [12, 13]}}
{"token": ["The", "authors", "emphasize", "the", "development", "of", "intolerance", "manifestations", "to", "the", "lens", "(", "C0042166#ent", "<e1>", ",", "uveitis", ",", "sterile", "hypopion", ",", "C0024440#ent", "<e2>", "."], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024440", "name": "C0024440#ent", "pos": [20, 21]}}
{"token": ["A", "case", "of", "C0042166#ent", "<e1>", "associated", "classic", "snowbanking", "(", "pars", "planitis", "with", "severe", "C0024440#ent", "<e2>", "due", "to", "Lyme", "borreliosis", "reported", "."], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024440", "name": "C0024440#ent", "pos": [13, 14]}}
{"token": ["C1420017#ent", "<e1>", "increased", "in", "C2698698#ent", "<e2>", "with", "the", "8", "%", "salt", "diet"], "h": {"id": "C1420017", "name": "C1420017#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2698698", "name": "C2698698#ent", "pos": [4, 5]}}
{"token": ["Among", "eleven", "cDNA-expressed", "CYPs", "studied", ",", "C1332830#ent", "<e1>", "and", "CYP1A2", "exhibited", "significant", "activity", "for", "the", "C0008286#ent", "<e2>", "7-hydroxylation", "."], "h": {"id": "C1332830", "name": "C1332830#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [15, 16]}}
{"token": ["We", "showed", "the", "relationship", "for", "a", "family", "of", "ligands", "between", "LR", "and", "LRG", "affinity", "and", "characterized", "the", "affinity", "of", "both", "the", "C2987364#ent", "<e1>", "and", "GFP", "fusion", "receptors", "C0086376#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [27, 28]}}
{"token": ["These", "proteases", "include", "the", "S2P", "family", "of", "C0025543#ent", "<e1>", ",", "the", "Rhomboid", "family", "of", "C2717971#ent", "<e2>", "and", "two", "aspartyl", "proteases", "the", "signal", "peptide", "peptidase", "SPP", ")", "and", "gamma-secretase", "."], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [14, 15]}}
{"token": ["The", "highly", "induced", "genes", "included", "extracellular", "matrix", "components", ",", "C0025543#ent", "<e1>", ",", "and", "a", "C2717971#ent", "<e2>"], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [14, 15]}}
{"token": ["The", "Finnish", "variant", "late", "infantile", "C0027877#ent", "<e1>", "vLINCL", ")", "belongs", "to", "the", "neuronal", "ceroid", "C0268279#ent", "<e2>", "group", "of", "common", "recessively", "inherited", "neurodegenerative", "disorders"], "h": {"id": "C0027877", "name": "C0027877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268279", "name": "C0268279#ent", "pos": [14, 15]}}
{"token": ["C1307941#ent", "<e1>", "contains", "a", "C1334706#ent", "<e2>", "a", "disintegrin", "domain", "three", "thrombospondin-like", "repeats", "but", "unlike", "ADAMs", "lacks", "a", "transmembrane", "domain"], "h": {"id": "C1307941", "name": "C1307941#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [4, 5]}}
{"token": ["In", "contrast", ",", "two", "other", "proteases", ",", "C1307941#ent", "<e1>", "(", "A", "disintegrin", "and", "C1334706#ent", "<e2>", "with", "thrombospondin-like", "motifs", ")", "and", "cathepsin", "L", "a", "lysosomal", "cysteine", "protease", ",", "are", "transcriptional", "targets", "of", "PR", "action", "."], "h": {"id": "C1307941", "name": "C1307941#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [13, 14]}}
{"token": ["The", "present", "study", "was", "aimed", "to", "reveal", "mechanisms", "by", "which", "C0069919#ent", "<e1>", "perturbs", "the", "C1539078#ent", "<e2>"], "h": {"id": "C0069919", "name": "C0069919#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "the", "mGluR4", "specific", "C0243192#ent", "<e1>", "might", "exert", "neuroprotective", "effects", "C0031404#ent", "<e2>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031404", "name": "C0031404#ent", "pos": [11, 12]}}
{"token": ["The", "rank", "order", "of", "potency", "of", "C0243192#ent", "<e1>", "was", ":", "5-HT", "greater", "than", "C0031404#ent", "<e2>", "=", "2-methyl-5-HT", "much", "greater", "than", "5-methoxytryptamine", "=", "5-carboxamidotryptamine", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031404", "name": "C0031404#ent", "pos": [13, 14]}}
{"token": ["These", "include", "the", "bile", "acid-binding", "resin", "cholestyramine", ",", "nicotinic", "acid", "C0017245#ent", "<e1>", ",", "phenytoin", ",", "exogenous", "estrogens", ",", "and", "C0001975#ent", "<e2>", "."], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [19, 20]}}
{"token": ["The", "fifth", "patient", ",", "who", "was", "C0019693#ent", "<e1>", "positive", ",", "had", "a", "C1413309#ent", "<e2>", "facial", "eruption"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [12, 13]}}
{"token": ["We", "observed", "that", "when", "co-expressed", "with", "C0162565#ent", "<e1>", ",", "protein", "levels", "both", "Aurora-A", "and", "C3711547#ent", "<e2>", "are", "markedly", "elevated", "regardless", "of", "their", "kinase", "activities", "phosphorylation", "state", "of", "C0162565#ent", "<e1>", "."], "h": {"id": "C0162565", "name": "C0162565#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3711547", "name": "C3711547#ent", "pos": [14, 15]}}
{"token": ["Many", "patients", "who", "present", "with", "advanced", "C0343755#ent", "<e1>", "have", "comorbid", "conditions", "such", "as", "C0019163#ent", "<e2>", "C", "or", "tuberculosis", "(", "TB", ")", ",", "which", "complicates", "the", "choice", "of", "therapy", "."], "h": {"id": "C0343755", "name": "C0343755#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [13, 14]}}
{"token": ["Our", "data", "show", "the", "C0427055#ent", "<e1>", "of", "arguments", "which", "separate", "insulin-dependent", "from", "C0011860#ent", "<e2>", "patients", "in", "acute", "diabetes", "mellitus", "recent", "onset", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}}
{"token": ["Our", "data", "show", "the", "C0427055#ent", "<e1>", "of", "arguments", "which", "separate", "C0011860#ent", "<e2>", "from", "non", "insulin-dependent", "patients", "in", "acute", "diabetes", "mellitus", "recent", "onset", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [10, 11]}}
{"token": ["The", "technique", "of", "immunodecoration", "with", "antibodies", "against", "C0599220#ent", "<e1>", "proton-ATPases", "from", "yeast", "mitochondria", ",", "spinach", "C3179066#ent", "<e2>", ",", "and", "E.", "coli", "membranes", "was", "used", "for", "quantitative", "estimation", "of", "proton-ATPase", "complexes", "in", "chromaffin", "granules", "mitochondrial", "membranes"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [15, 16]}}
{"token": ["Thirty-four", "mongrel", "dogs", "were", "classified", "as", "thrombosis", "prone", "(", "C3541334#ent", "<e1>", ")", "or", "thrombosis", "resistant", "(", "C0040961#ent", "<e2>", ")", "on", "the", "basis", "of", "in", "vitro", "platelet", "aggregation", "to", "AA", "."], "h": {"id": "C3541334", "name": "C3541334#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [16, 17]}}
{"token": ["The", "C0003308#ent", "<e1>", "three", "antibiotics", "of", "the", "iturin", "group", "iturin", "A", "mycosubtilin", ",", "C0052871#ent", "<e2>", "of", "eleven", "methylated", "and", "acetylated", "derivatives", "of", "these", "antibiotics", "was", "tested", "upon", "Saccharomyces", "cerevisiae"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0052871", "name": "C0052871#ent", "pos": [13, 14]}}
{"token": ["Second-step", "resistance", "required", "two", "mutations", ",", "ampC3", "and", "C1421222#ent", "<e1>", ",", "in", "addition", "to", "C3538771#ent", "<e2>", "and", "ampA2", "."], "h": {"id": "C1421222", "name": "C1421222#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3538771", "name": "C3538771#ent", "pos": [14, 15]}}
{"token": ["We", "studied", "the", "prevention", "and", "treatment", "of", "C0442874#ent", "<e1>", "with", "the", "selective", "alpha2-adrenergic", "agonist", "dexmedetomidine", "in", "male", "Sprague-Dawley", "rats", "unilateral", "C0031117#ent", "<e2>", "from", "tight", "ligation", "the", "L5", "and", "L6", "spinal", "nerves"], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [20, 21]}}
{"token": ["Mutations", "in", "the", "C1420348#ent", "<e1>", "which", "encodes", "the", "large", "C0018296#ent", "<e2>", "atlastin", ",", "are", "the", "second", "most", "common", "cause", "of", "autosomal", "dominant", "hereditary", "spastic", "paraplegia"], "h": {"id": "C1420348", "name": "C1420348#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "the", "C1420348#ent", "<e1>", "family", "of", "C0018296#ent", "<e2>", "functions", "prominently", "in", "both", "ER", "and", "Golgi", "morphogenesis", "but", "they", "do", "not", "appear", "to", "be", "required", "generally", "for", "anterograde", "ER-to-Golgi", "trafficking", "."], "h": {"id": "C1420348", "name": "C1420348#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [7, 8]}}
{"token": ["C0442893#ent", "<e1>", "including", "involvement", "of", "the", "kidney", ",", "C0151295#ent", "<e2>", "and", "skin", "vasculitis", "is", "treated", "with", "systemic", "glucocorticoids", "and", "cyclophosphamide", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0151295", "name": "C0151295#ent", "pos": [8, 9]}}
{"token": ["Previous", "experiments", "have", "defined", "six", "different", "sites", "that", "may", "contribute", "to", "the", "transcriptional", "control", "the", "C0879590#ent", "<e1>", "IL-2", ")", "promoter", ",", "and", "for", "each", ",", "active", "C1825958#ent", "<e2>", "induced", "upon", "mitogenic", "stimulation", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1825958", "name": "C1825958#ent", "pos": [26, 27]}}
{"token": ["The", "patterns", "of", "suppression", "at", "37", "and", "43.5", "C", ",", "identity", "of", "mapping", "site", "effects", "of", "C0017372#ent", "<e1>", "growth", "rate", "sporulation", ",", "and", "production", "of", "altered", "C3540017#ent", "<e2>", "were", "examined", "."], "h": {"id": "C0017372", "name": "C0017372#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [26, 27]}}
{"token": ["Thirty-four", "V", "elements", "11", "D", "elements", "DQ52", ",", "six", "J", "elements", "and", "the", "C0079941#ent", "<e1>", "Cmicro", ",", "Cgamma", ",", "C", "and", "four", "C2985256#ent", "<e2>", "identified", "and", "characterized", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2985256", "name": "C2985256#ent", "pos": [22, 23]}}
{"token": ["In", "untreated", "U251/NG2", "cells", ",", "C1419426#ent", "<e1>", "is", "present", "along", "with", "C1421450#ent", "<e2>", "and", "alpha(3)beta(1)", "integrin", "apical", "cell", "protrusions", "."], "h": {"id": "C1419426", "name": "C1419426#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421450", "name": "C1421450#ent", "pos": [11, 12]}}
{"token": ["Glutamate-cysteine", "ligase", "gamma-ECL", ")", "and", "C1415327#ent", "<e1>", "GS", ")", "are", "the", "two", "unrelated", "C0023689#ent", "<e2>", "that", "constitute", "the", "glutathione", "biosynthesis", "pathway", "most", "eukaryotes", ",", "purple", "bacteria", "and", "cyanobacteria", "."], "h": {"id": "C1415327", "name": "C1415327#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023689", "name": "C0023689#ent", "pos": [13, 14]}}
{"token": ["PC-3", "cells", "expressed", "high", "levels", "of", "membrane", "43-kDa", "C0015923#ent", "<e1>", "that", "were", "enhanced", "by", "C0042584#ent", "<e2>", "treatments", "."], "h": {"id": "C0015923", "name": "C0015923#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042584", "name": "C0042584#ent", "pos": [14, 15]}}
{"token": ["These", "results", "show", "that", "protonated", "2-APB", "directly", "and", "reversibly", "inhibits", "connexin", "channels", "of", "C4283800#ent", "<e1>", "and/or", "Cx32", "and", "suggest", "involvement", "of", "the", "C1416809#ent", "<e2>"], "h": {"id": "C4283800", "name": "C4283800#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416809", "name": "C1416809#ent", "pos": [22, 23]}}
{"token": ["The", "relaxations", "evoked", "by", "a", "donor", "of", "nitric", "oxide", "C0525082#ent", "<e1>", ",", "were", "minimally", "affected", "by", "C0108178#ent", "<e2>", "and", "nitro", "L-arginine"], "h": {"id": "C0525082", "name": "C0525082#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0108178", "name": "C0108178#ent", "pos": [16, 17]}}
{"token": ["After", "a", "staged", "bilateral", "carotid", "endarterectomy", "only", "one", "(", "1", "%", ")", "patient", "experienced", "transient", "C0007787#ent", "<e1>", ",", "but", "five", "(", "6", "%", ")", "patients", "suffered", "C0038454#ent", "<e2>", "four", "fatal", ")", "."], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [26, 27]}}
{"token": ["PAH-inducible", "UGTs", "may", "cooperate", "in", "the", "metabolism", "of", "C0031428#ent", "<e1>", "metabolites", "of", "C0005080#ent", "<e2>", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005080", "name": "C0005080#ent", "pos": [12, 13]}}
{"token": ["Mono-", "and", "C0031428#ent", "<e1>", "of", "chrysene", "and", "C0005080#ent", "<e2>", "are", "suspected", "substrates", "of", "a", "3-methylcholanthrene", "(MC)-inducible", "phenol", "UDP-glucuronosyltransferase", "(", "UGT1A1", ")", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005080", "name": "C0005080#ent", "pos": [7, 8]}}
{"token": ["Over-expression", "of", "C0061355#ent", "<e1>", "in", "transfected", "INS-1", "cells", "reduces", "the", "threshold", "for", "C0167117#ent", "<e2>", "agonist", "action", ",", "whereas", "basal", "RIP1-Luc", "activity", "increases", "2.5-fold", "in", "the", "absence", "of", "added", "agonist", "."], "h": {"id": "C0061355", "name": "C0061355#ent", "pos": [2, 3]}, "relation": "structural_class_of", "t": {"id": "C0167117", "name": "C0167117#ent", "pos": [12, 13]}}
{"token": ["Therefore", "a", "defect", "in", "one", "of", "the", "well", "known", "C1416742#ent", "<e1>", "be", "excluded", "as", "a", "cause", "of", "the", "C1848862#ent", "<e2>", "."], "h": {"id": "C1416742", "name": "C1416742#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [18, 19]}}
{"token": ["C0268418#ent", "<e1>", "GKD", ")", "is", "an", "X-linked", "genetic", "disease", "clinically", "by", "C0405580#ent", "<e2>", "muscular", "dystrophy"], "h": {"id": "C0268418", "name": "C0268418#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [11, 12]}}
{"token": ["Genomic", "DNA", "five", "previously", "unreported", "patients", "with", "C0268418#ent", "<e1>", "GKD", ")", ",", "dystrophic", "myopathy", "and", "C0405580#ent", "<e2>", "studied", "with", "genomic", "probes", "cDNA", "probes", "the", "Duchenne", "muscular", "dystrophy", "DMD", ")", "locus", "."], "h": {"id": "C0268418", "name": "C0268418#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [15, 16]}}
{"token": ["C0162316#ent", "<e1>", "alterations", "in", "the", "activity", "of", "muscle", ",", "hepatic", "and", "C0038615#ent", "<e2>", "and", "hepatic", "mitochondrial", "succinate", "cytochrome", "c", "reductase", "whereas", "Pb", "exposure", "had", "no", "influence", "on", "these", "enzymes", "."], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038615", "name": "C0038615#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "YGCGT", "treatment", "of", "T", "cells", "inhibits", "selectively", "nuclear", "translocation", "C1704704#ent", "<e1>", "and", "NFATc1", ",", "resulting", "in", "diminished", "production", "of", "C1522405#ent", "<e2>", "."], "h": {"id": "C1704704", "name": "C1704704#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [22, 23]}}
{"token": ["However", ",", "with", "C0053140#ent", "<e1>", "and", "phenylmethylsulfonylfluoride", "as", "protease", "inhibitors", "C0053409#ent", "<e2>", "produced", "only", "one", "protein", "band", "isoelectric", "focusing", "and", "gel", "electrophoresis", "respectively", "."], "h": {"id": "C0053140", "name": "C0053140#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0053409", "name": "C0053409#ent", "pos": [10, 11]}}
{"token": ["Finally", ",", "the", "role", "of", "C2927148#ent", "<e1>", "Th1-promoting", "cytokine", "suppression", "examined", ",", "and", "results", "with", "C2936804#ent", "<e2>", "that", "both", "cannabinoid", "receptors", "1", "2", "were", "involved", "."], "h": {"id": "C2927148", "name": "C2927148#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936804", "name": "C2936804#ent", "pos": [15, 16]}}
{"token": ["Adding", "AT", "III", "with", "heparin", "and", "C1414504#ent", "<e1>", "restores", "the", "C1366463#ent", "<e2>", "activity", "."], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366463", "name": "C1366463#ent", "pos": [10, 11]}}
{"token": ["Mice", "pretreated", "with", "Salmonella", "S-", "R-form", "LPS", "or", "free", "lipid", "A", "Salmonella", ")", "demonstrated", "tolerance", "and", "C0004096#ent", "<e1>", "to", "both", "C1334043#ent", "<e2>", "and", "heterologous", "challenge", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [20, 21]}}
{"token": ["Quercetin", ",", "myricetin", ",", "and", "C1257968#ent", "<e1>", "inhibited", "the", "formation", "of", "uric", "acid", "xanthine", "by", "C0043317#ent", "<e2>", "while", "rutin", "was", "ineffective", "."], "h": {"id": "C1257968", "name": "C1257968#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0043317", "name": "C0043317#ent", "pos": [15, 16]}}
{"token": ["We", "examined", "the", "effects", "of", "3'-azido-2',3'-dideoxythymidine", "(", "AZT", ",", "a", "C0282519#ent", "<e1>", ",", "pentamidine", "(", "a", "therapeutic", "drug", "C1535939#ent", "<e2>", "and", "calmodulin", "antagonists", "as", "trifluoperazine", "and", "N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide", "(", "W-7", ")", "on", "NO", "synthase", "activation", "."], "h": {"id": "C0282519", "name": "C0282519#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [18, 19]}}
{"token": ["By", "contrast", ",", "C0046764#ent", "<e1>", "was", "characterised", "by", "C0231807#ent", "<e2>", "short", "run", "ventricular", "tachycardia", "most", "of", "which", "had", "a", "right", "bundle", "branch", "block", "."], "h": {"id": "C0046764", "name": "C0046764#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0231807", "name": "C0231807#ent", "pos": [8, 9]}}
{"token": ["Following", "15", "-", "30", "days", "of", "EOS-treatment", ",", "the", "depolarization", "response", "to", "C0026818#ent", "<e1>", "was", "decreased", "and", "that", "to", "C0068781#ent", "<e2>", "increased", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0068781", "name": "C0068781#ent", "pos": [19, 20]}}
{"token": ["Bilateral", "microinjection", "either", "C0026818#ent", "<e1>", "or", "baclofen", "into", "the", "vlNTS", "mimicked", "the", "effect", "of", "C0068781#ent", "<e2>"], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0068781", "name": "C0068781#ent", "pos": [14, 15]}}
{"token": ["Twenty-one", "patients", "of", "ischaemic", "stroke", "put", "on", "prolonged", "administration", "of", "C0085826#ent", "<e1>", "aspirin", "320", "mg", "once", "daily", "with", "C0072511#ent", "<e2>", "400", "mg", "thrice", "daily", ")", "."], "h": {"id": "C0085826", "name": "C0085826#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0072511", "name": "C0072511#ent", "pos": [18, 19]}}
{"token": ["This", "ratio", "was", "similar", "in", "subjects", "with", "either", "an", "C0014921#ent", "<e1>", "or", "a", "PM", "phenotype", "and", "was", "not", "altered", "by", "C0034414#ent", "<e2>", "administration", "."], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [20, 21]}}
{"token": ["Different", "NKG2", "members", "could", "be", "associated", "with", "C1334311#ent", "<e1>", ",", "either", "inhibitory", "(", "NKG2A/B", ")", "or", "activating", "(", "C1416683#ent", "<e2>", ")", "."], "h": {"id": "C1334311", "name": "C1334311#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416683", "name": "C1416683#ent", "pos": [18, 19]}}
{"token": ["An", "evolutionary", "analysis", "across", "primates", "reveals", "that", "whereas", "C1334311#ent", "<e1>", "is", "evolving", "under", "purifying", "selection", "both", "NKG2A", "and", "C1416683#ent", "<e2>", "are", "evolving", "under", "positive", "selection", "."], "h": {"id": "C1334311", "name": "C1334311#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416683", "name": "C1416683#ent", "pos": [18, 19]}}
{"token": ["Instead", ",", "pob3", "mutants", "displayed", "reduced", "binding", "of", "both", "pol", "II", "C1337106#ent", "<e1>", "to", "the", "C1416829#ent", "<e2>", "promoter", "."], "h": {"id": "C1337106", "name": "C1337106#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416829", "name": "C1416829#ent", "pos": [15, 16]}}
{"token": ["Isoproterenol", "effects", "were", "also", "increased", "when", "C0282210#ent", "<e1>", "was", "evaluated", "in", "whole", "blood", "specimens", "from", "subjects", "after", "a", "loading", "dose", "C0002575#ent", "<e2>", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [20, 21]}}
{"token": ["C0040961#ent", "<e1>", "was", "induced", "while", "C1415275#ent", "<e2>", "was", "repressed", "in", "malignancies", "relative", "to", "controls", "in", "transgenic", "mice", "prostate", "cell", "lines"], "h": {"id": "C0040961", "name": "C0040961#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415275", "name": "C1415275#ent", "pos": [5, 6]}}
{"token": ["The", "NS3", "protein", "has", "other", "C3540790#ent", "<e1>", "within", "its", "sequence", "(", "C1333949#ent", "<e2>", ",", "nucleoside", "triphosphatase", "RNA", "triphosphatase", ",", "all", "of", "which", "are", "tightly", "regulated", "through", "localisation", "within", "membranous", "compartments", "the", "infected", "cell", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [11, 12]}}
{"token": ["In", "the", "studies", "with", "flying", "squirrel", "C0030756#ent", "<e1>", ",", "however", ",", "transmission", "of", "C0041473#ent", "<e2>", "infected", "to", "uninfected", "flying", "squirrels", "was", "demonstrated", "."], "h": {"id": "C0030756", "name": "C0030756#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041473", "name": "C0041473#ent", "pos": [13, 14]}}
{"token": ["The", "ICDH-II", "classifies", "headache", "disorders", "3", "parts", ":", "the", "primary", "headache", "the", "secondary", "headache", "C0010269#ent", "<e1>", "central", "and", "C0015468#ent", "<e2>", "other", "headaches", "."], "h": {"id": "C0010269", "name": "C0010269#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0015468", "name": "C0015468#ent", "pos": [18, 19]}}
{"token": ["The", "phosphodiesterase", "inhibitor", "C0030899#ent", "<e1>", "has", "been", "used", "as", "a", "motility", "C0304402#ent", "<e2>", "in", "the", "treatment", "of", "oligospermia", "in", "vitro"], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [11, 12]}}
{"token": ["This", "study", "showed", "that", "C0030899#ent", "<e1>", "could", "be", "used", "as", "a", "C0304402#ent", "<e2>", "of", "in", "vitro", "sperm", "motility", "male", "infertility", "."], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "case", "of", "accidental", "4-AP", "overdose", "that", "resulted", "in", "continuous", ",", "dystonic", ",", "choreoathetoid-type", "movements", "that", "responded", "to", "treatment", "with", "standard", "C0003286#ent", "<e1>", "dosages", "of", "C0005064#ent", "<e2>", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [27, 28]}}
{"token": ["Among", "C0003286#ent", "<e1>", "barbiturates", "and", "C0005064#ent", "<e2>", "are", "very", "effective", "against", "this", "type", "of", "epilepsy", ",", "whereas", "many", "other", "drugs", "are", "weakly", "active", "or", "toxic", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [5, 6]}}
{"token": ["The", "genes", "are", "linked", "to", "C1334043#ent", "<e1>", "of", "eukaryotic", "recombination", "and", "repair", "proteins", "C1417250#ent", "<e2>", "and", "Rad50", "in", "some", "of", "the", "genomes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417250", "name": "C1417250#ent", "pos": [13, 14]}}
{"token": ["We", "define", "a", "DNA", "damage", "checkpoint", "pathway", "S.", "cerevisiae", "by", "the", "C1334043#ent", "<e1>", "Tel1", "and", "the", "C1417250#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417250", "name": "C1417250#ent", "pos": [16, 17]}}
{"token": ["Studies", "using", "a", "monoclonal", "(", "C1172764#ent", "<e1>", ")", "and", "a", "polyclonal", "antibody", "p-AMACR", ")", "to", "alpha-methylacyl-CoA", "racemase", "C1412374#ent", "<e2>", ")", "have", "shown", "variable", "expression", "in", "prostate", "cancer", "PCa", ")", "."], "h": {"id": "C1172764", "name": "C1172764#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412374", "name": "C1412374#ent", "pos": [17, 18]}}
{"token": ["Western", "blot", "analysis", "pulse-chase", "experiments", "support", "the", "interpretation", "that", "after", "C1419030#ent", "<e1>", "cleavage", "into", "p25", ",", "C1332738#ent", "<e2>", ",", "and", "p13", ",", "only", "C1332738#ent", "<e2>", "expresses", "this", "epitope", "."], "h": {"id": "C1419030", "name": "C1419030#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332738", "name": "C1332738#ent", "pos": [16, 17]}}
{"token": ["C1540205#ent", "<e1>", "did", "not", "affect", "the", "early", "activation", "events", "of", "C1705050#ent", "<e2>", ",", "but", "C1540205#ent", "<e1>", "enhanced", "the", "Stat5-dependent", "transcriptional", "activation", "HC11", "cells"], "h": {"id": "C1540205", "name": "C1540205#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705050", "name": "C1705050#ent", "pos": [10, 11]}}
{"token": ["C1540205#ent", "<e1>", "appears", "to", "be", "distinct", "from", "JAK2", ",", "Vav", ",", "C1705050#ent", "<e2>", ",", "and", "c-Cbl", "."], "h": {"id": "C1540205", "name": "C1540205#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705050", "name": "C1705050#ent", "pos": [11, 12]}}
{"token": ["To", "clarify", "further", "the", "role", "of", "the", "Fhit", "protein", "gastric", "carcinogenesis", "we", "investigated", "whether", "C0919457#ent", "<e1>", "expression", "in", "early", "gastric", "neoplasia", "associated", "with", "C0879392#ent", "<e2>", "expression", "and", "cellular", "phenotype"], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0879392", "name": "C0879392#ent", "pos": [23, 24]}}
{"token": ["Recent", "studies", "have", "suggested", "that", "C0919457#ent", "<e1>", "inactivation", "can", "be", "a", "consequence", "of", "defects", "in", "C0879392#ent", "<e2>", "particularly", "mut", "S", "homolog", "2", "MSH2", ")", "."], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0879392", "name": "C0879392#ent", "pos": [15, 16]}}
{"token": ["C0028127#ent", "<e1>", ",", "another", "dihydropyridine", "derivative", "bound", "specifically", "to", "C1366526#ent", "<e2>", "homogenate", "in", "a", "saturable", "manner", "."], "h": {"id": "C0028127", "name": "C0028127#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [9, 10]}}
{"token": ["The", "mitochondrial", "A3243", "G", "tRNALeu(UUR", ")", "mutation", "associated", "with", "variety", "of", "C0751651#ent", "<e1>", "results", "in", "a", "severe", "respiratory", "deficiency", "an", "increase", "in", "reactive", "oxygen", "species", "C0812281#ent", "<e2>", ")", "production", "and", "activities", "of", "anti-oxidative", "enzyme", "in", "vitro"], "h": {"id": "C0751651", "name": "C0751651#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [25, 26]}}
{"token": ["C1864745#ent", "<e1>", "maps", "to", "C1417660#ent", "<e2>", ",", "a", "gene", "encoding", "an", "essential", "ubiquitin-protein", "ligase"], "h": {"id": "C1864745", "name": "C1864745#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417660", "name": "C1417660#ent", "pos": [4, 5]}}
{"token": ["Another", "feature", "of", "C0041234#ent", "<e1>", "the", "paucity", "of", "parasites", "in", "the", "C0277565#ent", "<e2>", "heart", "."], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [11, 12]}}
{"token": ["On", "immunocytochemistry", ",", "many", "vasoactive", "intestinal", "polypeptide", "(VIP)-immunoreactive", "ir", ")", "neurons", ",", "and", "a", "few", "C1420718#ent", "<e1>", "and", "substance", "P", "cells", "were", "recognized", "in", "C1258666#ent", "<e2>", ",", "but", "no", "calcitonin", "gene-related", "peptide", "neurons", "were", "found", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1258666", "name": "C1258666#ent", "pos": [24, 25]}}
{"token": ["The", "acute", "effects", "of", "C0071144#ent", "<e1>", "on", "atrial", "fibrillation", "investigated", "in", "40", "patients", "with", "C0235480#ent", "<e2>", "of", "atrial", "fibrillation"], "h": {"id": "C0071144", "name": "C0071144#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [14, 15]}}
{"token": ["The", "results", "suggest", "that", "C2983131#ent", "<e1>", "is", "not", "integrated", "in", "the", "C1334752#ent", "<e2>", "network", "."], "h": {"id": "C2983131", "name": "C2983131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334752", "name": "C1334752#ent", "pos": [11, 12]}}
{"token": ["The", "CBP/p300-interacting", "transactivator", "ED-rich", "tail", "2", "(", "CITED2", ")", "binds", "EP300", "and", "C1705776#ent", "<e1>", "with", "high", "affinity", "and", "regulates", "C0812327#ent", "<e2>"], "h": {"id": "C1705776", "name": "C1705776#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [19, 20]}}
{"token": ["The", "increased", "45Ca2", "+", "uptake", "in", "the", "differentiating", "cells", "was", "inhibited", "by", "C0280858#ent", "<e1>", ",", "cromolyn", "and", "C0546849#ent", "<e2>", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [17, 18]}}
{"token": ["In", "lower", "concentrations", ",", "the", "inhibitory", "potency", "of", "these", "was", ":", "C0280858#ent", "<e1>", "greater", "than", "cimetidine", "approximately", "C0546849#ent", "<e2>", "approximately", "quinidine", "greater", "than", "procainamide", "approximately", "N1-methylnicotinamide", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [17, 18]}}
{"token": ["Mutation", "in", "the", "X-linked", "class", "A", "gene", "shown", "to", "be", "the", "cause", "of", "C1418558#ent", "<e1>", "an", "acquired", "disease", "hematopoietic", "stem", "cells", "which", "the", "abnormal", "cells", "deficient", "in", "C3272445#ent", "<e2>"], "h": {"id": "C1418558", "name": "C1418558#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3272445", "name": "C3272445#ent", "pos": [27, 28]}}
{"token": ["Treatment", "of", "MDA-MB-231", "and", "HT115", "cells", "with", "C1425280#ent", "<e1>", ",", "at", "non-toxic", "levels", ",", "resulted", "in", "reduction", "of", "C1420342#ent", "<e2>", "in", "supernatant", "as", "well", "as", "in", "the", "cell", "lysate"], "h": {"id": "C1425280", "name": "C1425280#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [18, 19]}}
{"token": ["Analysis", "of", "the", "catalytic", "activity", "partially", "purified", "rat", "adipocyte", "C1419111#ent", "<e1>", "and", "LAR", "and", "recombinant", "C1709439#ent", "<e2>", "showed", "that", "all", "three", "PTPases", "dephosphorylate", "IR", "."], "h": {"id": "C1419111", "name": "C1419111#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1709439", "name": "C1709439#ent", "pos": [15, 16]}}
{"token": ["Fetal", "rat", "brain", "expressed", "four", "known", "receptor-like", "PTPs", "(", "PTP", "delta", ",", "LAR", ",", "LAR-PTP2", ",", "C1419111#ent", "<e1>", "(", "PTP", "alpha", ")", ")", "and", "the", "non-receptor", "phosphatase", "C1709439#ent", "<e2>", "."], "h": {"id": "C1419111", "name": "C1419111#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1709439", "name": "C1709439#ent", "pos": [27, 28]}}
{"token": ["In", "the", "present", "study", ",", "we", "purified", "the", "C0032594#ent", "<e1>", ",", "termed", "SHP", ",", "from", "C1822717#ent", "<e2>", "preparation", "and", "examined", "their", "immunomodulatory", "activity", "and", "in", "combination", "with", "interferon", "(IFN)-gamma", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1822717", "name": "C1822717#ent", "pos": [15, 16]}}
{"token": ["The", "study", "compared", "the", "long-term", "efficacy", "and", "safety", "of", "miglitol", "to", "placebo", "in", "C0011860#ent", "<e1>", "outpatients", "inadequately", "controlled", "on", "combination", "therapy", "diet", ",", "C0017628#ent", "<e2>", "and", "metformin", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [23, 24]}}
{"token": ["Oral", "first-line", "treatment", "C0011860#ent", "<e1>", "usually", "initiated", "with", "C0017628#ent", "<e2>", "(", "glyburide", ")", ",", "which", "is", "known", "to", "increase", "bodyweight", "(", "reflecting", "group", "B", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [8, 9]}}
{"token": ["A", "49-year-old", "man", "with", "non-insulin-dependent", "diabetes", "mellitus", "C0011860#ent", "<e1>", ")", "from", "alcoholic", "pancreatitis", "100", "mg", "of", "C0017628#ent", "<e2>", "without", "symptoms", "of", "hypoglycaemia", "even", "when", "C0017628#ent", "<e2>", "concentrations", "were", "high", "(", "191", "micrograms/l", ")", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [16, 17]}}
{"token": ["Altogether", ",", "these", "results", "demonstrate", "that", "5-HT(2A/2C)", "receptor", "agonists", "promote", "locomotion", "while", "5-HT(1B", ")", "and", "5-HT(2B/2C)", "receptor", "agonists", "with", "locomotor", "C4255166#ent", "<e1>", "in", "the", "hindlimbs", "of", "complete", "C0030486#ent", "<e2>"], "h": {"id": "C4255166", "name": "C4255166#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0030486", "name": "C0030486#ent", "pos": [27, 28]}}
{"token": ["Metabolism", "by", "both", "C3541394#ent", "<e1>", "was", "completely", "inhibited", "by", "the", "specific", "C0053444#ent", "<e2>", "saccharic", "acid-1,4-lactone", "0.5", "mM", ")", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0053444", "name": "C0053444#ent", "pos": [11, 12]}}
{"token": ["Sex", ",", "age", ",", "cumulative", "and", "current", "C0033229#ent", "<e1>", "cumulative", "and", "current", "C0242896#ent", "<e2>", "anti-epileptic", "medication", "status", "did", "not", "predict", "the", "Parkinsonism", "scores", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [12, 13]}}
{"token": ["15", "times", "weaker", "than", "that", "of", "C0033229#ent", "<e1>", ",", "furthermore", "urapidil", "has", "no", "C0242896#ent", "<e2>"], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [13, 14]}}
{"token": ["The", "probable", "site", "of", "involvement", "responsible", "for", "the", "SN", "loss", "was", "the", "cochlea", ",", "and", "discontinuity", "of", "the", "ossicles", ",", "rather", "than", "C0427008#ent", "<e1>", ",", "was", "responsible", "for", "the", "C0018777#ent", "<e2>"], "h": {"id": "C0427008", "name": "C0427008#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0018777", "name": "C0018777#ent", "pos": [29, 30]}}
{"token": ["A", "C1120843#ent", "<e1>", "SB", "203580", ",", "inhibited", "LPS-stimulated", "COX-2", "expression", "and", "C3272750#ent", "<e2>", "activation", "suggesting", "that", "LPS", "may", "activate", "the", "NF-kappaB", "signaling", "pathway", "upstream", "p38", "MAPK", "activation", "."], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3272750", "name": "C3272750#ent", "pos": [11, 12]}}
{"token": ["C0771315#ent", "<e1>", ",", "a", "proton", "pump", "inhibitor", "provided", "an", "augmentation", "of", "C1136254#ent", "<e2>", "to", "that", "of", "the", "phenothiazines", ",", "suggesting", "that", "the", "phenothiazines", "might", "have", "interfered", "with", "the", "proton", "gradient", "the", "inner", "membrane"], "h": {"id": "C0771315", "name": "C0771315#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [11, 12]}}
{"token": ["Stimulation", "of", "transfected", "cells", "with", "fMLP", "resulted", "in", "the", "time-", "and", "dose-dependent", "increase", "in", "tyrosine", "phosphorylation", "activation", "of", "C0082529#ent", "<e1>", "and", "ERK2", "and", "the", "activation", "of", "MEK", ",", "the", "C1367675#ent", "<e2>"], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1367675", "name": "C1367675#ent", "pos": [29, 30]}}
{"token": ["Starting", "from", "1984", ",", "this", "method", "was", "employed", "in", "the", "treatment", "of", "133", "patients", ",", "of", "these", "102", "ones", "with", "atherosclerosis", "obliterans", "the", "lower", "limb", "vessels", "17", "with", "C0014100#ent", "<e1>", "and", "14", "with", "C1282916#ent", "<e2>"], "h": {"id": "C0014100", "name": "C0014100#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1282916", "name": "C1282916#ent", "pos": [33, 34]}}
{"token": ["At", "autopsy", ",", "C0023890#ent", "<e1>", "esophageal", "varices", "confirmed", "and", "unilateral", "chronic", "pyelonephritis", "C0392525#ent", "<e2>", "testicular", "atrophy", "found", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [12, 13]}}
{"token": ["C0013618#ent", "<e1>", "is", "a", "chelator", "which", "indirectly", "prevents", "oxidation", "of", "C0237406#ent", "<e2>", "."], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0237406", "name": "C0237406#ent", "pos": [10, 11]}}
{"token": ["Sequence", "analysis", "that", "C0266789#ent", "<e1>", "accompanied", "by", "removal", "of", "the", "first", "17", "C3539947#ent", "<e2>"], "h": {"id": "C0266789", "name": "C0266789#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}}
{"token": ["To", "isolate", "the", "gene", "for", "C0812309#ent", "<e1>", ",", "we", "have", "cloned", "several", "novel", "human", "C1707117#ent", "<e2>"], "h": {"id": "C0812309", "name": "C0812309#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1707117", "name": "C1707117#ent", "pos": [14, 15]}}
{"token": ["Hemoptysis", "can", "be", "caused", "by", "a", "variety", "of", "C0034072#ent", "<e1>", "including", "parasitic", "infections", "tuberculosis", ",", "C0008677#ent", "<e2>", "malignancies", "."], "h": {"id": "C0034072", "name": "C0034072#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [15, 16]}}
{"token": ["Third", ",", "a", "slight", "molar", "excess", "of", "C1415790#ent", "<e1>", "able", "to", "abolish", ",", "almost", "completely", ",", "the", "C1706373#ent", "<e2>", "in", "chaperonin", "60", "."], "h": {"id": "C1415790", "name": "C1415790#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [17, 18]}}
{"token": ["Mycobacterium", "xenopi", "a", "recognized", "cause", "of", "C0024115#ent", "<e1>", "patients", "with", "C0746102#ent", "<e2>"], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0746102", "name": "C0746102#ent", "pos": [10, 11]}}
{"token": ["Univariate", "and", "multivariate", "analysis", "logistic", "regression", "not", "show", "relationships", "between", "exercise-related", "cardiac", "arrhythmias", "the", "severity", "of", "C0024115#ent", "<e1>", "oxyhemoglobin", "desaturation", "ECG", "evidence", "of", "C0746102#ent", "<e2>"], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0746102", "name": "C0746102#ent", "pos": [23, 24]}}
{"token": ["The", "C1825621#ent", "<e1>", "on", "human", "chromosome", "21", "a", "large", "C1333729#ent", "<e2>", "with", "antiviral", "activity", "distinct", "negative-strand", "RNA", "viruses", "notably", "influenza", "viruses"], "h": {"id": "C1825621", "name": "C1825621#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333729", "name": "C1333729#ent", "pos": [9, 10]}}
{"token": ["The", "C1883695#ent", "<e1>", "properties", "of", "C0025605#ent", "<e2>", "are", "ascribed", "almost", "entirely", "to", "the", "(-)-methadone", "enantiomer", "."], "h": {"id": "C1883695", "name": "C1883695#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025605", "name": "C0025605#ent", "pos": [5, 6]}}
{"token": ["Chronic", "inflammation", "C0006035#ent", "<e1>", "be", "sustained", "by", "aberrant", "inflammatory", "response", "characterized", "by", "C3540579#ent", "<e2>", "lymphocyte", "predominance", ",", "which", "in", "turn", "may", "be", "determined", "by", "chemokines", "synthesized", "in", "inflammatory", "focus"], "h": {"id": "C0006035", "name": "C0006035#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [12, 13]}}
{"token": ["Severe", "C0030312#ent", "<e1>", "developed", "in", "two", "infants", "with", "C0268575#ent", "<e2>"], "h": {"id": "C0030312", "name": "C0030312#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0268575", "name": "C0268575#ent", "pos": [8, 9]}}
{"token": ["C0117059#ent", "<e1>", "production", "was", "demonstrated", "in", "64", "clinical", "C1875400#ent", "<e2>", "of", "S.", "marcescens"], "h": {"id": "C0117059", "name": "C0117059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [8, 9]}}
{"token": ["We", "analyzed", "the", "culture", "supernatant", "proteins", "(", "C0117059#ent", "<e1>", ")", "from", "a", "TSLS-related", "C1875400#ent", "<e2>", "belonging", "to", "M3", "serotype", "S.", "pyogenes", "two-dimensional", "gel", "electrophoresis", "characterized", "a", "single", "protein", "spot", "by", "using", "BLAST", "database", "."], "h": {"id": "C0117059", "name": "C0117059#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [13, 14]}}
{"token": ["Since", "C1414402#ent", "<e1>", "is", "basically", "a", "secretory", "protein", "cell", "supernatants", "co-culture", "cells", "treated", "with", "C2697656#ent", "<e2>", "were", "examined", "for", "AMBP-1", "protein", "."], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [14, 15]}}
{"token": ["It", "is", "a", "C0162757#ent", "<e1>", "selective", "antagonist", "of", "C1415811#ent", "<e2>", "and", "has", "been", "shown", "to", "be", "active", "in", "several", "animal", "models", "depression", "."], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415811", "name": "C1415811#ent", "pos": [8, 9]}}
{"token": ["Mechanistically", ",", "FH535", "inhibits", "recruitment", "of", "the", "coactivators", "C1332803#ent", "<e1>", "and", "GRIP1", "but", "not", "the", "corepressors", "NCoR", "C1705506#ent", "<e2>", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705506", "name": "C1705506#ent", "pos": [17, 18]}}
{"token": ["They", "had", "major", "C0027765#ent", "<e1>", "severe", "neonatal", "asphyxia", ",", "holoprocencephaly", ",", "microcephaly", ",", "C1456654#ent", "<e2>", "the", "central", "nervous", "system", "unknown", "origin", ",", "metachromatic", "leukodystrophy", "trisomy", "of", "chromosome", "18", "anoxic", "encephalopathy", "small", "for", "gestational", "age", "newborn", "with", "intracranial", "bleeding", "posthemorrhagic", "hydrocephalus"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C1456654", "name": "C1456654#ent", "pos": [13, 14]}}
{"token": ["Ras", "controls", "activation", "of", "extracellular", "signal-regulated", "kinases", "ERKs", ")", ",", "while", "C1705328#ent", "<e1>", "and", "Cdc42", "regulate", "the", "C0248813#ent", "<e2>", "JNKs", ")", "."], "h": {"id": "C1705328", "name": "C1705328#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [17, 18]}}
{"token": ["The", "small", "GTPases", "Cdc42", "and", "C1705328#ent", "<e1>", "regulate", "a", "variety", "of", "biological", "processes", "including", "actin", "polymerization", "cell", "proliferation", "and", "C0248813#ent", "<e2>", "conceivably", "via", "distinct", "effectors", "."], "h": {"id": "C1705328", "name": "C1705328#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "the", "membrane", "fractions", "transgenic", "worms", "expressing", "recombinant", "MBOA-7", "and", "its", "human", "C1334043#ent", "<e1>", "exhibited", "remarkably", "increased", "C1423536#ent", "<e2>", "activity", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1423536", "name": "C1423536#ent", "pos": [18, 19]}}
{"token": ["Renal", "biopsy", "C0017661#ent", "<e1>", "crescents", ",", "and", "HLA", "typing", "the", "presence", "of", "C1420806#ent", "<e2>", "and", "DR4", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420806", "name": "C1420806#ent", "pos": [12, 13]}}
{"token": ["C0033215#ent", "<e1>", "showed", "no", "effect", "the", "C0524928#ent", "<e2>", "centered", "radicals", "."], "h": {"id": "C0033215", "name": "C0033215#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [6, 7]}}
{"token": ["All", "of", "these", "characteristics", "suggest", "that", "C2986630#ent", "<e1>", "is", "a", "good", "candidate", "for", "a", "C0010691#ent", "<e2>"], "h": {"id": "C2986630", "name": "C2986630#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [14, 15]}}
{"token": ["Genetic", "linkage", "analysis", "markers", "of", "the", "genomic", "region", "C2986630#ent", "<e1>", "in", "chromosome", "2", "G", "band", "2p16.3", "and", "intragenic", "markers", "C2986630#ent", "<e1>", "have", "demonstrated", "genetic", "heterogeneity", "C0010691#ent", "<e1>", ";", "the", "rBAT", "gene", "linked", "to", "type", "I", "cystinuria", ",", "but", "not", "to", "type", "III"], "h": {"id": "C2986630", "name": "C2986630#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [25, 26]}}
{"token": ["Recently", ",", "several", "mutations", "in", "C2986630#ent", "<e1>", "from", "Japanese", "patients", "with", "C0010691#ent", "<e2>", "have", "been", "reported", "from", "our", "laboratory", "."], "h": {"id": "C2986630", "name": "C2986630#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [11, 12]}}
{"token": ["Four", "deaths", "were", "attributed", "to", "the", "C0003195#ent", "<e1>", "effects", "of", "C0079856#ent", "<e2>", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [6, 7]}, "relation": "therapeutic_class_of", "t": {"id": "C0079856", "name": "C0079856#ent", "pos": [10, 11]}}
{"token": ["The", "authors", "studied", "the", "effect", "of", "phenothiazine", "and", "butyrophenone", "neuroleptics", "that", "of", "the", "C0003195#ent", "<e1>", "etmozine", "and", "C0079856#ent", "<e2>", "on", "the", "dopamine", "--", "activated", "adenylate", "cyclase", "the", "rabbit", "brain", "striatum"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0079856", "name": "C0079856#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "suggest", "that", "the", "primary", "electrophysiological", "effect", "Ro", "22", "9194", "as", "an", "C0003195#ent", "<e1>", "is", ",", "like", "C0079856#ent", "<e2>", ",", "a", "use-", "and", "voltage-dependent", "inhibition", "sodium", "channels"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0079856", "name": "C0079856#ent", "pos": [18, 19]}}
{"token": ["This", "suggests", "that", "C3641847#ent", "<e1>", "may", "facilitate", "the", "anchorage", "of", "C0042720#ent", "<e2>", "cellular", "chromosomes", "thus", "ensuring", "proper", "partition", "and", "retention", "."], "h": {"id": "C3641847", "name": "C3641847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042720", "name": "C0042720#ent", "pos": [10, 11]}}
{"token": ["As", "cells", "are", "stimulated", "to", "divide", ",", "the", "presence", "of", "C3641847#ent", "<e1>", "ensures", "that", "the", "C0042720#ent", "<e2>", "replicate", "and", "be", "distributed", "to", "progeny", "cells"], "h": {"id": "C3641847", "name": "C3641847#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042720", "name": "C0042720#ent", "pos": [15, 16]}}
{"token": ["The", "antigranulation", "activity", "of", "CN-100", "was", "also", "nearly", "equal", "to", "that", "of", "C0015837#ent", "<e1>", "and", "weaker", "than", "that", "of", "C0030082#ent", "<e2>", "."], "h": {"id": "C0015837", "name": "C0015837#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030082", "name": "C0030082#ent", "pos": [19, 20]}}
{"token": ["Seven", "patients", "with", "essential", "hypertension", "seven", "patients", "with", "hypertension", "associated", "with", "renal", "artery", "stenosis", "captopril", "(", "C0733566#ent", "<e1>", ",", "an", "inhibitor", "of", "angiotensin", "I", "C0014442#ent", "<e2>", "."], "h": {"id": "C0733566", "name": "C0733566#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [24, 25]}}
{"token": ["The", "presence", "of", "a", "C1332788#ent", "<e1>", "detected", "in", "cells", "with", "the", "C1416799#ent", "<e2>", "mutation", "after", "curing", "of", "the", "R1", "plasmid"], "h": {"id": "C1332788", "name": "C1332788#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416799", "name": "C1416799#ent", "pos": [11, 12]}}
{"token": ["The", "appearance", "rate", "of", "C0031024#ent", "<e1>", "Dp3", "was", "higher", "than", "in", "C1415238#ent", "<e2>", "."], "h": {"id": "C0031024", "name": "C0031024#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415238", "name": "C1415238#ent", "pos": [11, 12]}}
{"token": ["Men", "and", "women", "(", "n", "=", "223", ")", "with", "C0022104#ent", "<e1>", "participating", "in", "a", "C0009373#ent", "<e2>", "registry", "completed", "measures", "for", "this", "cross-sectional", "study"], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0009373", "name": "C0009373#ent", "pos": [14, 15]}}
{"token": ["RIF", "induced", "CYP3A4", ",", "3A5", ",", "2B6", ",", "2A6", ",", "UGT1A1", ",", "UGT1A6", "and", "C1412070#ent", "<e1>", ",", "MRP2", "and", "MDR1", "and", "slightly", "downregulated", "C1420132#ent", "<e2>", "."], "h": {"id": "C1412070", "name": "C1412070#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420132", "name": "C1420132#ent", "pos": [23, 24]}}
{"token": ["They", "also", "review", "the", "nuclear", "receptor-mediated", "regulation", "drug", "transporters", "as", "MDR1", ",", "MRP2", ",", "MRP4", ",", "C1412070#ent", "<e1>", ",", "BCRP", ",", "NTCP", ",", "C1420132#ent", "<e2>", ",", "and", "OATP1A2", "."], "h": {"id": "C1412070", "name": "C1412070#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420132", "name": "C1420132#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "use", "yeast", "artificial", "chromosomes", "inserts", "that", "span", "the", "X", "chromosomal", "breakpoint", "a", "female", "C1417931#ent", "<e1>", "patient", "in", "order", "to", "isolate", "complementary", "C0011519#ent", "<e2>", "for", "a", "gene", "that", "is", "interrupted", "by", "the", "translocation", "."], "h": {"id": "C1417931", "name": "C1417931#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [23, 24]}}
{"token": ["Chromosomal", "assignment", "of", "the", "genes", "for", "two", "major", "human", "C0684287#ent", "<e1>", "that", "is", ",", "cytosolic", "aldehyde", "dehydrogenase-1", "ALDH1", ")", "and", "C4083146#ent", "<e2>", "ALDH2", ")", "were", "determined", "."], "h": {"id": "C0684287", "name": "C0684287#ent", "pos": [9, 10]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C4083146", "name": "C4083146#ent", "pos": [20, 21]}}
{"token": ["To", "evaluate", "the", "relationship", "between", "C0553730#ent", "<e1>", "and", "the", "progression", "of", "C0409959#ent", "<e2>", "OA", ")", "using", "longitudinal", "magnetic", "resonance", "imaging", "MRI", ")", "assessments", "."], "h": {"id": "C0553730", "name": "C0553730#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0409959", "name": "C0409959#ent", "pos": [11, 12]}}
{"token": ["The", "basal", "glucose", "uptake", "by", "the", "C3815598#ent", "<e1>", "and", "Sol", "muscles", "unchanged", "in", "C0020550#ent", "<e2>", "rats", "using", "the", "wet", "weight", "muscle", "as", "a", "reference", "."], "h": {"id": "C3815598", "name": "C3815598#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "expression", "of", "the", "dominant", "negative", "mutant", "of", "C1413714#ent", "<e1>", "or", "of", "DAPk", "antisense", "mRNA", "reduced", "autophagy", "induced", "by", "C0752229#ent", "<e2>", ",", "amino", "acid", "starvation", ",", "or", "administration", "of", "interferon-gamma", "."], "h": {"id": "C1413714", "name": "C1413714#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0752229", "name": "C0752229#ent", "pos": [21, 22]}}
{"token": ["The", "C0243051#ent", "<e1>", "norepinephrine", "is", "metabolized", "by", "monoamine", "oxidase", "an", "C0030438#ent", "<e2>", "intermediate", "that", "is", "further", "metabolized", "to", "the", "stable", "glycol", "derivative", ",", "3,4-dihydroxyphenylglycol", "(", "DHPG", ")", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030438", "name": "C0030438#ent", "pos": [10, 11]}}
{"token": ["Sustained", "Ca++", "free", "contractions", "to", "C0006945#ent", "<e1>", "were", "prevented/abolished", "by", "C0028066#ent", "<e2>", "or", "increased", "Ca++", "chelation", "and", "enhanced", "by", "BayK8644", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [10, 11]}}
{"token": ["These", "data", "suggest", "that", "C0297666#ent", "<e1>", "likely", "attenuates", "C1416867#ent", "<e2>", "via", "the", "inhibition", "of", "kinases", "other", "than", "p38", ",", "which", "may", "include", "JNK", "."], "h": {"id": "C0297666", "name": "C0297666#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [8, 9]}}
{"token": ["C2266971#ent", "<e1>", "the", "first", "C1136254#ent", "<e2>", "effectively", "to", "treat", "infectious", "diseases"], "h": {"id": "C2266971", "name": "C2266971#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [4, 5]}}
{"token": ["The", "C1418531#ent", "<e1>", "gene", "encodes", "the", "C4048261#ent", "<e2>", "catalyzes", "the", "transition", "of", "3-phosphoglycerate", "into", "3-phosphohydroxy", "pyruvate", "for", "the", "phosphorylated", "pathway", "serine", "biosynthesis"], "h": {"id": "C1418531", "name": "C1418531#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4048261", "name": "C4048261#ent", "pos": [6, 7]}}
{"token": ["Both", "trans-", "and", "C0016367#ent", "<e1>", "significantly", "decreased", "the", "C1706269#ent", "<e2>", "immunoreactivity", "in", "the", "right", "cerebellum", "24", "weeks", "of", "treatment", "."], "h": {"id": "C0016367", "name": "C0016367#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706269", "name": "C1706269#ent", "pos": [8, 9]}}
{"token": ["This", "deficit", "alone", "does", "not", "explain", "the", "reduced", "C0009952#ent", "<e1>", "response", ",", "as", "C0242889#ent", "<e2>", "not", "suppress", "the", "C0009952#ent", "<e1>", "response", "of", "young", "animals"], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [8, 9]}}
{"token": ["It", "is", "now", "feasible", "to", "examine", "directly", "the", "effects", "of", "C0009187#ent", "<e1>", "the", "host", "'s", "C1334911#ent", "<e2>"], "h": {"id": "C0009187", "name": "C0009187#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334911", "name": "C1334911#ent", "pos": [15, 16]}}
{"token": ["As", "C0013570#ent", "<e1>", "and", "microsatellite", "alleles", "the", "PRNP", "were", "observed", "in", "typical", "combinations", ",", "the", "microsatellite", "genotypes", "significantly", "associated", "with", "C0074204#ent", "<e2>", "incidences", "or", "risk", "classes", "on", "the", "C0013570#ent", "<e1>", "genotypes", "."], "h": {"id": "C0074204", "name": "C0074204#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [1, 2]}}
{"token": ["The", "one", "remaining", "h", "C2697645#ent", "<e1>", "had", "erosion", "of", "the", "posterior", "wall", "secondary", "to", "C0037771#ent", "<e2>", "and", "the", "posterior", "wall", "reconstructed", "."], "h": {"id": "C2697645", "name": "C2697645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037771", "name": "C0037771#ent", "pos": [14, 15]}}
{"token": ["C1423571#ent", "<e1>", "causes", "a", "C0039082#ent", "<e2>", "in", "chickens", "characterised", "by", "increased", "mortality", ",", "anaemia", "associated", "with", "atrophy", "of", "the", "haematopoietic", "tissues", "the", "bone", "marrow", "subcutaneous", "and", "intramuscular", "haemorrhages", ",", "and", "atrophy", "of", "the", "lymphoid", "system"], "h": {"id": "C1423571", "name": "C1423571#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [4, 5]}}
{"token": ["The", "C0079941#ent", "<e1>", "both", "species", "encodes", "a", "296", "amino", "acid", "protein", "which", "for", "murine", "C1417530#ent", "<e2>", "is", "53", "amino", "acids", "than", "originally", "published", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417530", "name": "C1417530#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "study", ",", "we", "demonstrated", "C0812327#ent", "<e1>", "c-fms", "in", "smooth", "muscle", "cells", "isolated", "from", "an", "experimental", "rabbit", "model", "of", "C0003850#ent", "<e2>", "(", "intimal", "smooth", "muscle", "cells", ",", "although", "there", "was", "no", "C0812327#ent", "<e1>", "c-fms", "detected", "in", "medial", "smooth", "muscle", "cells"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [7, 8]}}
{"token": ["The", "C3639962#ent", "<e1>", "the", "same", "breakpoint", "in", "C0812385#ent", "<e2>", "as", "is", "found", "in", "the", "BCR/ABL", "p210"], "h": {"id": "C3639962", "name": "C3639962#ent", "pos": [1, 2]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [7, 8]}}
{"token": ["Rat", "data", "demonstrate", "that", "the", "hypercholesterolemia", "induced", "by", "exogenous", "cholesterol", "administration", "is", "of", "a", "lesser", "magnitude", "in", "the", "presence", "of", "soy", "compared", "to", "C0007332#ent", "<e1>", "as", "a", "C0012177#ent", "<e2>", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [23, 24]}, "relation": "has_structural_class", "t": {"id": "C0012177", "name": "C0012177#ent", "pos": [27, 28]}}
{"token": ["Expression", "of", "the", "C0907533#ent", "<e1>", "active", "form", "either", "MEKK1", "or", "C0666248#ent", "<e2>", "mimicked", "the", "action", "of", "retinoic", "acid", "inducing", "these", "embryonal", "carcinoma", "cells", "primitive", "endoderm", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0666248", "name": "C0666248#ent", "pos": [10, 11]}}
{"token": ["Over", "the", "past", "30", "years", ",", "several", "C0035064#ent", "<e1>", "have", "been", "tested", "but", "cisplatin", "and", "C0020823#ent", "<e2>", "are", "the", "C0035064#ent", "<e1>", "that", "have", "attracted", "the", "greater", "attention", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [15, 16]}}
{"token": ["C4284459#ent", "<e1>", "alone", "promotes", "D-loop", "formation", "but", "C1826262#ent", "<e2>", "and", "the", "Hop2-Mnd1", "complex", "do", "not", "."], "h": {"id": "C4284459", "name": "C4284459#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826262", "name": "C1826262#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "the", "influence", "of", "sex", "hormones", "the", "physiology", "of", "the", "C1367469#ent", "<e1>", "axis", "through", "the", "modulation", "of", "the", "C0034307#ent", "<e2>", "type", "II", "activities", "is", "of", "great", "importance", "on", "stress", "and", "neuropathology", "associated", "with", "HPA", "dysfunction"], "h": {"id": "C1367469", "name": "C1367469#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0034307", "name": "C0034307#ent", "pos": [19, 20]}}
{"token": ["Mean", "C1420002#ent", "<e1>", "in", "infants", "with", "C3542407#ent", "<e2>", "and", "in", "control", "subjects", "16.2", "+", "/-", "9.3", "and", "61.2", "+", "/-", "30.6", "microg/ml", "of", "ELF", ",", "respectively", "(", "p", "=", "0.03", ")", "."], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "the", "different", "effect", "of", "C0020923#ent", "<e1>", ",", "pyridine", "and", "thiazole", "on", "the", "alkaline", "transformation", "of", "C0010583#ent", "<e2>", "discussed", "."], "h": {"id": "C0020923", "name": "C0020923#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [17, 18]}}
{"token": ["Fifty-three", "patients", "with", "C0038013#ent", "<e1>", "etodolac", "(", "400", "mg/day", ")", "and", "55", "patients", "received", "C0012091#ent", "<e2>", "(", "150", "mg/day", ")", "for", "12", "weeks", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [14, 15]}}
{"token": ["In", "these", "cells", ",", "C2984537#ent", "<e1>", "activation", "reduced", "cholesterol", "esterification", "and", "Acyl-CoA", ":", "C0023194#ent", "<e2>", "ACAT1", ")", "activity", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023194", "name": "C0023194#ent", "pos": [13, 14]}}
{"token": ["We", "obtained", "540", "predictions", "for", "105", "drugs", "(", "e.g.", ",", "captopril", ",", "C0024027#ent", "<e1>", ",", "flurbiprofen", ",", "metyrapone", ",", "and", "C0036079#ent", "<e2>", ",", "and", "calculated", "the", "binding", "affinities", "using", "AutoDock", "simulation", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036079", "name": "C0036079#ent", "pos": [20, 21]}}
{"token": ["A", "series", "of", "6", "experiments", "was", "conducted", "to", "test", "the", "efficacy", "of", "C0025023#ent", "<e1>", "in", "eliminating", "naturally", "occurring", "C0086227#ent", "<e2>", "mice", "."], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0086227", "name": "C0086227#ent", "pos": [18, 19]}}
{"token": ["Instead", ",", "by", "binding", "to", "C1414382#ent", "<e1>", ",", "lysozyme", "prevented", "the", "C0030946#ent", "<e2>", "from", "interacting", "with", "the", "elastin", "substrate", "ways", "that", "normally", "favor", "proteolysis", "."], "h": {"id": "C1414382", "name": "C1414382#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [11, 12]}}
{"token": ["Inhibition", "profiles", "production", "of", "nascent", "N-terminal", "leucine", "residues", "and", "sodium", "dodecyl", "sulphate/polyacrylamide-gel", "electrophoresis", "degraded", "C1414382#ent", "<e1>", "indicated", "that", "macrophage", "elastase", "an", "C0030946#ent", "<e2>", ",", "with", "properties", "of", "a", "metalloproteinase", ",", "rather", "than", "a", "serine", "proteinase"], "h": {"id": "C1414382", "name": "C1414382#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [21, 22]}}
{"token": ["Studies", "of", "enzyme", "partitioning", "between", "the", "phases", "showed", "that", "C0284930#ent", "<e1>", "adsorption", "on", "elastin", ";", "C0054871#ent", "<e2>", "the", "aqueous", "environment", ",", "and", "cathepsin", "S", "equally", "distributed", "among", "both", "phases", "."], "h": {"id": "C0284930", "name": "C0284930#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [15, 16]}}
{"token": ["A", "limited", "number", "of", "samples", "with", "middle", "ear", "pathology", ",", "including", "C0029899#ent", "<e1>", ",", "did", "not", "show", "altered", "C1425280#ent", "<e2>", "levels", "."], "h": {"id": "C0029899", "name": "C0029899#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1425280", "name": "C1425280#ent", "pos": [18, 19]}}
{"token": ["Mechanistic", "analysis", "showed", "that", "the", "C0752312#ent", "<e1>", "effect", "on", "C1705523#ent", "<e2>", "is", "mediated", "by", "Skp2", "and", "is", "secondary", "to", "its", "effect", "on", "cyclin", "D1"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705523", "name": "C1705523#ent", "pos": [9, 10]}}
{"token": ["C0037285#ent", "<e1>", "SCD", "may", "result", "in", "C0022661#ent", "<e2>", "ESRD", ")", ",", "which", "can", "be", "treated", "by", "chronic", "haemodialysis", "renal", "transplantation"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [6, 7]}}
{"token": ["The", "stimulation", "of", "glucose", "transport", "insulin", "or", "PMA", "was", "blocked", "by", "100", "nM", "wortmannin", "or", "10", "ng/ml", "C0251991#ent", "<e1>", ",", "indicating", "that", "PI", "3-kinase", "essential", "for", "stimulation", "by", "both", "C0035064#ent", "<e2>", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [29, 30]}}
{"token": ["This", "translocation", "fuses", "the", "AML1", "gene", "chromosome", "21q", "the", "MTG8", "(", "C1539715#ent", "<e1>", ")", "gene", "on", "chromosome", "8q", "produce", "the", "C1851466#ent", "<e2>"], "h": {"id": "C1539715", "name": "C1539715#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1851466", "name": "C1851466#ent", "pos": [20, 21]}}
{"token": ["The", "patients", "were", "given", "new", "hypotensive", "drugs", "minoxidyl", ",", "C0006938#ent", "<e1>", ",", "prazosine", ")", ",", "which", "lowered", "C1366439#ent", "<e2>", "and", "permitted", "a", "reduction", "of", "hypotensive", "injections", "during", "hemodialysis", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366439", "name": "C1366439#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "these", "results", "suggest", "that", "the", "C1419337#ent", "<e1>", "and", "GAD67", "promoters", "are", "subject", "to", "continuous", "repression", "by", "C1414121#ent", "<e2>", "that", "inhibitors", "of", "C1414121#ent", "<e2>", "a", "potential", "treatment", "for", "Schizophrenia", "."], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414121", "name": "C1414121#ent", "pos": [18, 19]}}
{"token": ["Using", "the", "chromatin", "immunoprecipitation", "assay", "C1420492#ent", "<e1>", ")", ",", "we", "demonstrated", "that", "C1824584#ent", "<e2>", "was", "not", "only", "a", "component", "of", "the", "SP-B", "promoter", ",", "but", "was", "also", "a", "component", "of", "the", "SP-C", "promoter", "complex", "lung", "cells"], "h": {"id": "C1420492", "name": "C1420492#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1824584", "name": "C1824584#ent", "pos": [12, 13]}}
{"token": ["Co-administration", "of", "pyrazole", "(", "an", "inhibitor", "of", "C3659502#ent", "<e1>", "with", "benzyl", "acetate", "an", "11-fold", "increase", "in", "the", "excretion", "of", "C0073858#ent", "<e2>", "halved", "the", "percentage", "of", "the", "dose", "excreted", "as", "benzoyl", "glucuronide"], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0073858", "name": "C0073858#ent", "pos": [19, 20]}}
{"token": ["The", "major", "apparent", "control", "points", "located", "at", "malate", "and", "C1415876#ent", "<e1>", "and", "less", "frequently", "at", "citrate", "synthase", "C1850941#ent", "<e2>", "."], "h": {"id": "C1415876", "name": "C1415876#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1850941", "name": "C1850941#ent", "pos": [17, 18]}}
{"token": ["Overexpressed", "genes", "Secreted", "Phosphoprotein", "1", "C1420369#ent", "<e1>", ",", "Osteopontin", ")", ",", "and", "Matrix", "Metalloproteinases-2", "-14", "(", "C1334522#ent", "<e2>", "and", "Mmp14", ")", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334522", "name": "C1334522#ent", "pos": [16, 17]}}
{"token": ["C0218158#ent", "<e1>", "Btk", ")", ",", "a", "downstream", "effector", "of", "C1705590#ent", "<e2>", "signals", "through", "B", "cell", "linker", "protein", "BLNK", ")", "and", "phospholipase", "C", "(PLC)gamma2", "to", "mediate", "B", "cell", "proliferation", "survival", "in", "response", "to", "BCR", "cross-linking", "."], "h": {"id": "C0218158", "name": "C0218158#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [9, 10]}}
{"token": ["It", "is", "concluded", "that", "C0037533#ent", "<e1>", "but", "not", "ANP", "or", "C0060180#ent", "<e2>", ",", "potentiates", "the", "depressor", "response", "zaprinast", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060180", "name": "C0060180#ent", "pos": [10, 11]}}
{"token": ["Using", "C2350558#ent", "<e1>", "flavopiridol", ",", "we", "identified", "glycogen", "phosphorylases", "C1705010#ent", "<e2>", ")", "from", "liver", "and", "brain", "as", "flavopiridol", "binding", "proteins", "HeLa", "cell", "extract"], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705010", "name": "C1705010#ent", "pos": [9, 10]}}
{"token": ["In", "a", "three-month", ",", "double-masked", "clinical", "trial", "92", "patients", "with", "C0017612#ent", "<e1>", "ocular", "hypertension", "levobunolol", "0.5", "%", "or", "1", "%", "or", "C0087093#ent", "<e2>", "0.5", "%", "once", "daily", ",", "in", "both", "eyes", "."], "h": {"id": "C0017612", "name": "C0017612#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0087093", "name": "C0087093#ent", "pos": [21, 22]}}
{"token": ["This", "review", "focuses", "on", "the", "role", "of", "oxidative", "stress", "C0021390#ent", "<e1>", "and", "the", "C3828567#ent", "<e2>", "inhibitor", "OPC-6535", "(", "tetomilast", ")", ",", "an", "investigational", "agent", "the", "treatment", "of", "UC", "."], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3828567", "name": "C3828567#ent", "pos": [13, 14]}}
{"token": ["Foxo1", "(", "C1705723#ent", "<e1>", ")", "contains", "15", "consensus", "phosphorylation", "sites", "for", "the", "C0752312#ent", "<e2>", "MAPK", ")", "family", "."], "h": {"id": "C1705723", "name": "C1705723#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [12, 13]}}
{"token": ["C1333217#ent", "<e1>", "encoded", "by", "a", "336-triplets", "C1412821#ent", "<e2>"], "h": {"id": "C1333217", "name": "C1333217#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [6, 7]}}
{"token": ["To", "achieve", "efficient", "and", "stable", "expression", "of", "heterologous", "exogenetic", "protein", "or", "antigen", "in", "E.", "coli", ",", "the", "C1334435#ent", "<e1>", "knocked", "in", "C1421976#ent", "<e2>", "site", "of", "chromosome", "lac", "operon", "using", "Red", "recombination", "system", "selection-counterselection", "kan/sacB", "technology", "."], "h": {"id": "C1334435", "name": "C1334435#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [21, 22]}}
{"token": ["alpha-Difluoromethylornithine", "(", "DFMO", ")", ",", "an", "irreversible", "inhibitor", "of", "the", "polyamine", "biosynthetic", "enzyme", "C0029282#ent", "<e1>", "ODC", ")", ",", "inhibits", "C0079973#ent", "<e2>", "colon", "tumorigenesis", "in", "carcinogen-treated", "animal", "models", "mechanisms", "yet", "to", "be", "elucidated", "."], "h": {"id": "C0029282", "name": "C0029282#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0079973", "name": "C0079973#ent", "pos": [19, 20]}}
{"token": ["With", "the", "development", "of", "monospecific", "antibodies", "C0040676#ent", "<e1>", "well", "as", "cDNA", "probes", "cloned", "C1336799#ent", "<e2>", "the", "study", "of", "glycosylation", "and", "its", "regulatory", "mechanisms", "great", "promise", "for", "the", "future", "."], "h": {"id": "C0040676", "name": "C0040676#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1336799", "name": "C1336799#ent", "pos": [13, 14]}}
{"token": ["Nucleotide", "interconversion", "enzymes", "adenylosuccinate", "lyase", "EC", "4.3.2.2", ";", "adenylosuccinate", "synthetase", "EC", "6.3.4.4", ";", "IMP", "dehydrogenase", "EC", "1.2.1.14", ";", "C0061779#ent", "<e1>", "EC", "6.3.5.2", "and", "C0061778#ent", "<e2>", "EC", "1.6.6.8", ")", "were", "not", "detected", "."], "h": {"id": "C0061779", "name": "C0061779#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0061778", "name": "C0061778#ent", "pos": [23, 24]}}
{"token": ["This", "study", "compares", "C0004238#ent", "<e1>", "burden", "with", "unifocal", "pacing", "UP", ")", "vs", "BP", "under", "C0026289#ent", "<e2>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0026289", "name": "C0026289#ent", "pos": [14, 15]}}
{"token": ["C1442750#ent", "<e1>", "binds", "eIF4A", "but", "not", "C1414351#ent", "<e2>", "and", "inhibits", "both", "cap-dependent", "and", "cap-independent", "translation"], "h": {"id": "C1442750", "name": "C1442750#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414351", "name": "C1414351#ent", "pos": [6, 7]}}
{"token": ["One", "of", "the", "downstream", "targets", "of", "p53", "transcription", "control", "is", "the", "WAF1/CIP1", "gene", ",", "whose", "gene", "product", "p21", "interacts", "with", "several", "cyclins", "and", "C0243045#ent", "<e1>", "resulting", "in", "inhibition", "of", "these", "C0031727#ent", "<e2>", "."], "h": {"id": "C0243045", "name": "C0243045#ent", "pos": [23, 24]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [30, 31]}}
{"token": ["C0525635#ent", "<e1>", "(", "BB", "form", ")", "and", "C0538135#ent", "<e2>", "were", "the", "major", "high-", "and", "low-Km", "aldehyde", "dehydrogenase", "the", "esophagus", ",", "respectively", "."], "h": {"id": "C0525635", "name": "C0525635#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0538135", "name": "C0538135#ent", "pos": [7, 8]}}
{"token": ["It", "has", "been", "proposed", "that", "the", "formation", "of", "the", "tetramer", "is", "prevented", "by", "the", "presence", "of", "a", "C-terminal", "tail", "C0525635#ent", "<e1>", "that", "is", "not", "present", "in", "C0538135#ent", "<e2>", "or", "2", "."], "h": {"id": "C0525635", "name": "C0525635#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0538135", "name": "C0538135#ent", "pos": [26, 27]}}
{"token": ["C1332806#ent", "<e1>", "an", "aminopeptidase", "as", "well", "as", "an", "C0207564#ent", "<e2>", "."], "h": {"id": "C1332806", "name": "C1332806#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0207564", "name": "C0207564#ent", "pos": [8, 9]}}
{"token": ["All", "the", "C1332416#ent", "<e1>", "patients", "have", "evidence", "of", "C1565489#ent", "<e2>", "to", "cyclosporin", "nephrotoxicity", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "suggest", "that", "hypothalamic", "galanin", "but", "not", "C1414945#ent", "<e1>", ",", "may", "play", "roles", "in", "GH", "secretion", "induced", "by", "C0242898#ent", "<e2>", "mechanisms", "in", "the", "rat", "."], "h": {"id": "C1414945", "name": "C1414945#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [19, 20]}}
{"token": ["C0282179#ent", "<e1>", "FH", ")", "and", "C0142278#ent", "<e2>", "SH", ")", "were", "taken", "as", "examples", "of", "synthetic", "drugs", "adulterant", ")", ",", "and", "the", "correlative", "peaks", "their", "synchronous", "2D", "correlation", "spectra", "were", "found", "."], "h": {"id": "C0282179", "name": "C0282179#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0142278", "name": "C0142278#ent", "pos": [5, 6]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "C0022104#ent", "<e1>", "and", "population", "C1517495#ent", "<e2>", "the", "aphid", "Macrosiphoniella", "tanacetaria", "a", "specialist", "herbivore", "of", "tansy", "(", "Tanacetum", "vulgare", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1517495", "name": "C1517495#ent", "pos": [10, 11]}}
{"token": ["C0027360#ent", "<e1>", "increased", "heart", "rate", "decreased", "self-reported", "measures", "vigor", "and", "C0020175#ent", "<e2>", "but", "did", "not", "alter", "any", "of", "the", "effects", "of", "THC", "."], "h": {"id": "C0027360", "name": "C0027360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020175", "name": "C0020175#ent", "pos": [10, 11]}}
{"token": ["C0027360#ent", "<e1>", "also", "blocked", "the", "increases", "in", "C0020175#ent", "<e2>", "occurred", "across", "time", "in", "the", "placebo", "condition", "."], "h": {"id": "C0027360", "name": "C0027360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020175", "name": "C0020175#ent", "pos": [7, 8]}}
{"token": ["Intravenous", "C0287041#ent", "<e1>", "increased", "Gmax", "in", "C0018802#ent", "<e2>", "(", "to", "-3.01", "+", "/-", "0.14%/mmHg", ",", "P", "<", "0.05", ")", "but", "not", "in", "C", "rats", "(", "to", "-3.56", "+", "/-", "0.19%/mmHg", ")", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [6, 7]}}
{"token": ["Cytochrome", "b5", "content", "and", "C1824841#ent", "<e1>", "varied", "little", "throughout", "the", "C0021831#ent", "<e2>"], "h": {"id": "C1824841", "name": "C1824841#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [10, 11]}}
{"token": ["Ethene-ATP", "exhibited", "competitive", "inhibition", "against", "C1705556#ent", "<e1>", "and", "noncompetitive", "inhibition", "respect", "to", "C3810616#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3810616", "name": "C3810616#ent", "pos": [12, 13]}}
{"token": ["We", "have", "demonstrated", "that", "Arabidopsis", "PII", "binds", "to", "the", "small", "molecules", "C1705556#ent", "<e1>", ",", "ADP", ",", "2KG", ",", "and", "with", "lesser", "affinity", "C3810616#ent", "<e2>", ",", "using", "isothermal", "titration", "calorimetry"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3810616", "name": "C3810616#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "this", "study", "establishes", "that", "C1417694#ent", "<e1>", "represents", "a", "potential", "therapeutic", "target", "for", "C0005940#ent", "<e2>", "reveals", "a", "mechanism", "that", "underlies", "the", "essential", "role", "of", "C1417694#ent", "<e1>", "in", "bone", "homeostasis"], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417694", "name": "C1417694#ent", "pos": [6, 7]}}
{"token": ["Chronic", "granulomatous", "disease", "C1863999#ent", "<e1>", ")", "is", "a", "C0024291#ent", "<e2>", "by", "mutations", "in", "nicotinamide", "dinucleotide", "phosphate", "NADPH", ")", "oxidase", "subunits", "."], "h": {"id": "C1863999", "name": "C1863999#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024291", "name": "C0024291#ent", "pos": [8, 9]}}
{"token": ["We", "have", "previously", "shown", "that", "the", "incorporation", "of", "AmB", "into", "phospholipid", "vesicles", "markedly", "reduce", "the", "toxicity", "of", "the", "C1254351#ent", "<e1>", "for", "mammalian", "cells", "erythrocytes", ")", "without", "changing", "its", "C0003308#ent", "<e2>", "Mol", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [28, 29]}}
{"token": ["There", "is", "no", "compelling", "reason", "why", "such", "conditions", "as", "von", "Hippel-Lindau", "syndrome", "peripheral", "neurofibromatosis", "C0242292#ent", "<e1>", "and", "others", "should", "be", "reclassified", "as", "C0039082#ent", "<e2>", "although", "awareness", "of", "their", "collective", "endocrine", "abnormalities", "clinically", "important", "."], "h": {"id": "C0242292", "name": "C0242292#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [22, 23]}}
{"token": ["Finally", ",", "despite", "earlier", "reports", "of", "atorvastatin-mediated", "inhibition", "of", "C0070166#ent", "<e1>", "activation", "we", "did", "not", "find", "any", "patient", "with", "C1826511#ent", "<e2>", "taking", "both", "drugs", "."], "h": {"id": "C0070166", "name": "C0070166#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826511", "name": "C1826511#ent", "pos": [19, 20]}}
{"token": ["C0042769#ent", "<e1>", "be", "associated", "with", "lymphadenopathy", ";", "C0021345#ent", "<e2>", "is", "the", "most", "striking", "example", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [7, 8]}}
{"token": ["Because", "of", "the", "discrepancies", "in", "the", "specificity", "of", "C1412276#ent", "<e1>", ",", "we", "examined", "the", "sera", "of", "patients", "with", "C1832586#ent", "<e2>", ",", "pemphigus", "and", "pemphigoid", "for", "C1412276#ent", "<e1>", "both", "by", "enzyme", "immunoassay", "by", "immunofluorescence", "."], "h": {"id": "C1832586", "name": "C1832586#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412276", "name": "C1412276#ent", "pos": [8, 9]}}
{"token": ["We", "set", "out", "to", "evaluate", "alterations", "of", "the", "therapeutic", "target", "genes", "KIT", "(", "C1705969#ent", "<e1>", "117", ")", ",", "EGFR", ",", "and", "C0242957#ent", "<e2>", "in", "human", "retinoblastoma"], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [21, 22]}}
{"token": ["The", "overall", "incidence", "of", "C1705969#ent", "<e1>", "observed", "in", "this", "population", "of", "C0242957#ent", "<e2>", "+", "MBC", "patients", "treated", "with", "trastuzumab", "after", "HDC", "is", "not", "superior", "to", "that", "reported", "with", "concomitant", "trastuzumab", "and", "anthracyclines", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [11, 12]}}
{"token": ["These", "data", "demonstrate", "cross-tolerance", "to", "the", "C0003286#ent", "<e1>", "effects", "of", "pentylenetetrazole", "between", "C0024002#ent", "<e2>", "and", "alprazolam", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [12, 13]}}
{"token": ["C3273706#ent", "<e1>", "were", "mainly", "C0009952#ent", "<e2>", "neutropenia", "and", "grade", "4", "neutropenia", "for", ">", "or", "=", "7", "days", "."], "h": {"id": "C3273706", "name": "C3273706#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [4, 5]}}
{"token": ["Regrowth", "of", "vimentin", "fibers", "C0009262#ent", "<e1>", "treatment", "was", "slower", "with", "fibroblasts", "from", "C0276496#ent", "<e2>", "that", "of", "the", "control", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0276496", "name": "C0276496#ent", "pos": [12, 13]}}
{"token": ["Frequency", "of", "ingestion", "of", "food", "by", "Amoeba", "proteus", "not", "closely", "correlated", "with", "attachment", "to", "the", "substratum", "in", "C1412125#ent", "<e1>", "and", "KCl", "solutions", "to", "which", "C0771302#ent", "<e2>", "added", "."], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0771302", "name": "C0771302#ent", "pos": [24, 25]}}
{"token": ["Inhibition", "of", "C1412356#ent", "<e1>", "required", "much", "higher", "concentrations", "of", "these", "compounds", ",", "and", "C0033551#ent", "<e2>", "was", "not", "inhibited", "."], "h": {"id": "C1412356", "name": "C1412356#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [13, 14]}}
{"token": ["Additional", "experiments", "have", "shown", "that", "4,7,10,13-ETYA", "selectively", "blocked", "the", "C1412356#ent", "<e1>", "in", "washed", "human", "platelets", "with", "lesser", "activity", "the", "C0033551#ent", "<e2>", "."], "h": {"id": "C1412356", "name": "C1412356#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [19, 20]}}
{"token": ["Directly", "downstream", "from", "the", "operon", "are", "qui", "and", "C0031441#ent", "<e1>", "sets", "of", "enzymes", "that", "convert", "quinate", "and", "C1542030#ent", "<e2>", ",", "respectively", ",", "to", "protocatechuate", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1542030", "name": "C1542030#ent", "pos": [17, 18]}}
{"token": ["C1413036#ent", "<e1>", "limits", "platelet-rich", "thrombosis", "by", "C0389918#ent", "<e2>", "the", "Tyr(1605)-Met(1606", ")", "bond", "."], "h": {"id": "C1413036", "name": "C1413036#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0389918", "name": "C0389918#ent", "pos": [6, 7]}}
{"token": ["Anticardiolipin", "antibodies", "found", "in", "five", "patients", "(", "16", "%", ")", "with", "C1527336#ent", "<e1>", "in", "seven", "patients", "(", "22", "%", ")", "with", "C0151450#ent", "<e2>"], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0151450", "name": "C0151450#ent", "pos": [21, 22]}}
{"token": ["Sj\u00f6gren's", "syndrome", "occur", "in", "the", "absence", "(", "C1527336#ent", "<e1>", "or", "in", "the", "presence", "of", "other", "connective", "tissue", "disease", "C0151450#ent", "<e2>", "."], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0151450", "name": "C0151450#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "C1705360#ent", "<e1>", "like", "Pax1", "expression", "is", "dependent", "on", "C1335824#ent", "<e2>", "from", "the", "notochord", ",", "and", "C1705360#ent", "<e1>", "and", "Pax1", "act", "synergistically", "to", "generate", "the", "vertebral", "column"], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [5, 6]}}
{"token": ["The", "previous", "BN", "52021", "administration", "on", "rats", "treated", "with", "C0010592#ent", "<e1>", "blunted", "its", "effects", "on", "superficial", "C0722058#ent", "<e2>", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0722058", "name": "C0722058#ent", "pos": [16, 17]}}
{"token": ["Cholestyramine", "and", "gemfibrozil", "also", "prevented", "myocardial", "infarction", "men", "with", "more", "severe", "C0020443#ent", "<e1>", ";", "while", "C0009002#ent", "<e2>", "had", "a", "negative", "risk-benefit", "ratio", "in", "patients", "with", "moderate", "C0020443#ent", "<e1>", "."], "h": {"id": "C0009002", "name": "C0009002#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [11, 12]}}
{"token": ["Between", "1963", "and", "1968", ",", "57", "patients", "underwent", "partial", "ileal", "bypass", "(", "C0009002#ent", "<e1>", ")", "at", "the", "University", "of", "Minnesota", "C0020443#ent", "<e2>"], "h": {"id": "C0009002", "name": "C0009002#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [20, 21]}}
{"token": ["On", "C0054259#ent", "<e1>", "gel", "these", "bands", "exhibited", "C2932861#ent", "<e2>", "activity", "."], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2932861", "name": "C2932861#ent", "pos": [7, 8]}}
{"token": ["To", "investigate", "the", "relationship", "between", "the", "polymorphism", "of", "angiotensin", "converting", "enzyme", "ACE", ")", "gene", "and", "ACE", "inhibitor", "C0010200#ent", "<e1>", "in", "Chinese", "elderly", "with", "C0085580#ent", "<e2>"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "maternal", "T", "cells", "SRBC-immunized", "pregnant", "mice", "induce", "suppression", "of", "anti-SRBC", "C1418482#ent", "<e1>", "in", "offspring", "with", "restriction", "to", "major", "histocompatibility", "complex", "C0024518#ent", "<e2>", ")", "haplotype", "utilized", "in", "maternal", "T-cell", "responses", "during", "pregnancy", "."], "h": {"id": "C1418482", "name": "C1418482#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "maternal", "T", "cells", "SRBC-immunized", "pregnant", "mice", "induce", "suppression", "of", "anti-SRBC", "C1418482#ent", "<e1>", "in", "offspring", "with", "restriction", "to", "major", "C0024518#ent", "<e2>", "MHC", ")", "haplotype", "utilized", "in", "maternal", "T-cell", "responses", "during", "pregnancy", "."], "h": {"id": "C1418482", "name": "C1418482#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [20, 21]}}
{"token": ["To", "determine", "if", "overexpression", "of", "the", "SRp40", "isoforms", "altered", "C1367472#ent", "<e1>", "and", "C1367472#ent", "<e1>", "EDA", "organization", ",", "cDNAs", "encoding", "these", "isoforms", "were", "C3889446#ent", "<e1>", "in", "ATDC5", "cells", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [22, 23]}}
{"token": ["These", "observations", "suggest", "that", "the", "antipanic", "mechanism", "action", "of", "C0002333#ent", "<e1>", "may", "be", "due", "in", "part", "to", "an", "interaction", "between", "C0005064#ent", "<e2>", "and", "noradrenergic", "neural", "systems"], "h": {"id": "C0002333", "name": "C0002333#ent", "pos": [9, 10]}, "relation": "has_structural_class", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [20, 21]}}
{"token": ["The", "increases", "ranged", "from", "416", "to", "721", "%", "for", "C1704890#ent", "<e1>", "and", "from", "778", "to", "890", "%", "for", "C1421447#ent", "<e2>", "."], "h": {"id": "C1704890", "name": "C1704890#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421447", "name": "C1421447#ent", "pos": [18, 19]}}
{"token": ["The", "mean", "value", "estimated", "difficulty", "of", "work", "was", "higher", "in", "subjects", "taking", "drugs", "in", "general", ",", "as", "well", "as", "C0020592#ent", "<e1>", ",", "sedatives", ",", "analgesics", ",", "anti-inflammatory", "agents", "C0017173#ent", "<e2>"], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017173", "name": "C0017173#ent", "pos": [28, 29]}}
{"token": ["We", "aimed", "to", "identify", "these", "subsets", "of", "dyspepsia", ":", "\"", "frequent", "C0000737#ent", "<e1>", "satiety", "(", "ES", ")", ",", "\"", "and", "\"", "C0027498#ent", "<e2>", "(", "NV", ")", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027498", "name": "C0027498#ent", "pos": [21, 22]}}
{"token": ["Since", "the", "C1864903#ent", "<e1>", "action", "of", "sucrose", "can", "not", "be", "attributed", "to", "elevated", "C1415067#ent", "<e2>", "or", "glucose", "concentrations", "the", "involvement", "of", "other", "insulin-releasing", "hormones", "released", "from", "the", "intestine", "by", "sucrose", "is", "suggested", "."], "h": {"id": "C1864903", "name": "C1864903#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415067", "name": "C1415067#ent", "pos": [13, 14]}}
{"token": ["During", "a", "3-hour", "incubation", "period", ",", "LH", "and", "a", "non-specific", "C0001644#ent", "<e1>", "L-isoproterenol", "steadily", "increased", "C3536949#ent", "<e2>", "production", "with", "a", "similar", "time-course", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [15, 16]}}
{"token": ["This", "report", "highlights", "a", "possible", "causal", "role", "for", "C1959635#ent", "<e1>", "the", "pathogenesis", "of", "select", "C0024115#ent", "<e2>"], "h": {"id": "C1959635", "name": "C1959635#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [14, 15]}}
{"token": ["Our", "study", "identifies", "C1414463#ent", "<e1>", "as", "a", "new", "RAP80-interacting", "protein", "and", "suggests", "that", "C1823597#ent", "<e2>", "may", "be", "an", "important", "modulator", "of", "ERalpha", "activity"], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823597", "name": "C1823597#ent", "pos": [13, 14]}}
{"token": ["The", "most", "frequent", "conditions", "in", "the", "first", "group", "are", "Guillain-Barr\u00e9", "syndrome", "C0026896#ent", "<e1>", "and", "in", "the", "second", "group", ",", "polyneuropathy", "and", "C0026848#ent", "<e2>", "of", "the", "critically", "ill", "patient", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [21, 22]}}
{"token": ["The", "involvement", "of", "reactive", "oxygen", "species", "ROS", ")", "and", "C4042483#ent", "<e1>", "the", "mechanism", "of", "apoptosis", "induced", "by", "ornithine", "decarboxylase", "C0029282#ent", "<e2>", ")", "inhibition", "was", "also", "assessed", "."], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [19, 20]}}
{"token": ["A", "5'-region", "of", "C1869509#ent", "<e1>", "was", "defined", "by", "rescue", "of", "C1422161#ent", "<e2>"], "h": {"id": "C1869509", "name": "C1869509#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422161", "name": "C1422161#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "apraxia", "presence", "and", "time", "course", "C1823958#ent", "<e1>", ",", "MMSE", ",", "and", "C0061145#ent", "<e2>", "scores", "were", "investigated", "."], "h": {"id": "C1823958", "name": "C1823958#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0061145", "name": "C0061145#ent", "pos": [14, 15]}}
{"token": ["After", "16", "h", ",", "Na(+", ")", ",", "C0071766#ent", "<e1>", "ATPase", "abundance", "was", "increased", "in", "homogenates", ",", "while", "in", "C0005859#ent", "<e2>", "it", "was", "decreased", "."], "h": {"id": "C0071766", "name": "C0071766#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005859", "name": "C0005859#ent", "pos": [18, 19]}}
{"token": ["Hydrocortisone", "or", "C0701251#ent", "<e1>", "also", "reduced", "PGE", "tissue", "content", "of", "inflamed", "C1417163#ent", "<e2>", "by", "about", "74", "per", "cent", "during", "the", "period", "of", "incubation", "."], "h": {"id": "C0701251", "name": "C0701251#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417163", "name": "C1417163#ent", "pos": [11, 12]}}
{"token": ["Murine", "ASHP", "was", "discovered", "as", "a", "GATA-1", "target", "C0017337#ent", "<e1>", "and", "human", "C1425284#ent", "<e2>", "is", "directly", "regulated", "by", "GATA-1", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425284", "name": "C1425284#ent", "pos": [12, 13]}}
{"token": ["In", "addition", "to", "other", "characteristic", "features", "of", "this", "C1848862#ent", "<e1>", ",", "there", "was", "C0853888#ent", "<e2>", "and", "transient", "renal", "dysfunction", "to", "that", "observed", "in", "the", "'", "one-shot", "'", "experimental", "model", "serum", "sickness"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0853888", "name": "C0853888#ent", "pos": [13, 14]}}
{"token": ["Such", "a", "C1848862#ent", "<e1>", "should", "be", "included", "in", "the", "differential", "diagnosis", "C0853888#ent", "<e2>", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0853888", "name": "C0853888#ent", "pos": [11, 12]}}
{"token": ["Hypocomplementemic", "urticarial", "vasculitis", "syndrome", "(", "HUVS", ")", "is", "a", "C1848862#ent", "<e1>", "of", "recurrent", "urticarial", "vasculitis", "arthralgia/arthritis", ",", "and", "C0853888#ent", "<e2>", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0853888", "name": "C0853888#ent", "pos": [18, 19]}}
{"token": ["Serum", "levels", "of", "sIL-2R", "can", "be", "used", "to", "monitor", "in", "vivo", "immune", "activation", "its", "elevation", "have", "been", "shown", "to", "be", "correlated", "with", "T", "cell", "immune", "disease", "as", "C0011615#ent", "<e1>", "psoriasis", ",", "lymphoma", "and", "C1290138#ent", "<e2>"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [33, 34]}}
{"token": ["These", "revertants", "possess", "a", "wild-type", "sensitivity", "to", "the", "cytotoxicity", "of", "the", "C1254351#ent", "<e1>", "and", "contain", "a", "C0030016#ent", "<e2>", "with", "similar", "properties", "as", "wild-type", "enzyme", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [16, 17]}}
{"token": ["The", "selectivity", "of", "the", "C1254351#ent", "<e1>", "can", "be", "ascribed", "to", "the", "absence", "of", "the", "C0030016#ent", "<e2>", "in", "the", "human", "host", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [14, 15]}}
{"token": ["Several", "distinct", "mutations", "in", "exon", "2", "C0694897#ent", "<e1>", "disrupt", "binding", "of", "C0299505#ent", "<e2>", "to", "TBP-1", "."], "h": {"id": "C0694897", "name": "C0694897#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0299505", "name": "C0299505#ent", "pos": [11, 12]}}
{"token": ["While", "C1514550#ent", "<e1>", "casein", "kinase-1", "not", "undergo", "significant", "changes", ",", "C0054846#ent", "<e2>", "rises", "in", "both", "A-MuLV", "and", "M-MuLV", "infected", "lymphocytes", ",", "becoming", "largely", "associated", "with", "particulate", "fraction", "of", "transformed", "cells"], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054846", "name": "C0054846#ent", "pos": [10, 11]}}
{"token": ["In", "man", ",", "C0011854#ent", "<e1>", "NIDD", ")", "and", "healthy", "subjects", "postoperative", "(", "C1420368#ent", "<e2>", ")", "stress", "were", "examined", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420368", "name": "C1420368#ent", "pos": [12, 13]}}
{"token": ["At", "least", "3", "major", "manifestations", "characterize", "its", "clinical", "presentation", "fatal", "C0021345#ent", "<e1>", "FIM", ")", ",", "lymphomas", ",", "and", "C0162538#ent", "<e2>"], "h": {"id": "C0021345", "name": "C0021345#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162538", "name": "C0162538#ent", "pos": [18, 19]}}
{"token": ["Here", "we", "show", "that", "the", "acetylation", "of", "two", "lysine", "residues", "in", "p53", "promotes", "recruitment", "of", "the", "C1336612#ent", "<e1>", "TAF1", "to", "the", "C1420626#ent", "<e2>", "promoter", "through", "its", "bromodomains", "."], "h": {"id": "C1336612", "name": "C1336612#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [21, 22]}}
{"token": ["In", "this", "issue", "of", "the", "Biochemical", "Journal", "Alvarez", "and", "colleagues", "have", "identified", "C1418231#ent", "<e1>", "[", "poly(A)-binding", "protein", "1", "as", "a", "target", "of", "C1413132#ent", "<e2>", "HIV", "infection"], "h": {"id": "C1418231", "name": "C1418231#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413132", "name": "C1413132#ent", "pos": [22, 23]}}
{"token": ["In", "summary", ",", "our", "results", "indicate", "that", "HRGbeta-induced", "SOC", "was", "regulated", "by", "C1512127#ent", "<e1>", "level", "and", "dependent", "on", "activation", "of", "C0031669#ent", "<e2>", "in", "human", "breast", "cancer", "cells"], "h": {"id": "C1512127", "name": "C1512127#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [20, 21]}}
{"token": ["The", "repression", "mechanism", "of", "SHP", "involves", "several", "actions", "including", "competition", "with", "C1422492#ent", "<e1>", "binding", "on", "the", "AF-2", "of", "nuclear", "receptors", "recruitment", "of", "C0282519#ent", "<e2>", "as", "EID-1", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0282519", "name": "C0282519#ent", "pos": [22, 23]}}
{"token": ["Further", ",", "interactions", "between", "the", "maternal", "effect", "locus", "female", "C0017347#ent", "<e1>", "fsh", ")", "and", "C1540172#ent", "<e2>", "have", "been", "observed", "."], "h": {"id": "C0017347", "name": "C0017347#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1540172", "name": "C1540172#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "amino", "acids", "C1419384#ent", "<e1>", ",", "but", "not", "IGF1", ",", "activated", "C2827382#ent", "<e2>", "the", "knockin", "cells", ",", "supporting", "the", "idea", "that", "PtdIns(3,4,5)P3", "stimulates", "C2827382#ent", "<e2>", "PKB-mediated", "activation", "of", "C1419384#ent", "<e1>", "."], "h": {"id": "C1419384", "name": "C1419384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2827382", "name": "C2827382#ent", "pos": [12, 13]}}
{"token": ["Although", "not", "necessary", "for", "signaling", "to", "C0752312#ent", "<e1>", "in", "primary", "fibroblasts", "FAK", "may", "enhance", "and", "prolong", "integrin-mediated", "activation", "C0752312#ent", "<e1>", "through", "p130(CAS", ")", ",", "Crk", ",", "and", "C3814146#ent", "<e1>", "in", "cells", "expressing", "B-Raf", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3814146", "name": "C3814146#ent", "pos": [27, 28]}}
{"token": ["Here", ",", "we", "establish", "a", "novel", "link", "between", "the", "E6", "oncoprotein", "activation", "of", "C0752312#ent", "<e1>", "MAPK", ")", "signaling", "and", "show", "that", "this", "signaling", "involves", "C3814146#ent", "<e2>", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3814146", "name": "C3814146#ent", "pos": [24, 25]}}
{"token": ["The", "conclusions", "of", "this", "study", "are", "that", "C1838244#ent", "<e1>", "patients", "with", "C0004604#ent", "<e2>", "are", "not", "a", "separate", "C1838244#ent", "<e1>", "group", "and", "they", "responded", "well", "to", "conservative", "treatment"], "h": {"id": "C1838244", "name": "C1838244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [11, 12]}}
{"token": ["Investigations", "of", "the", "influence", "of", "C1838244#ent", "<e1>", "treatment", "on", "C0004604#ent", "<e2>", "are", "scarce", "."], "h": {"id": "C1838244", "name": "C1838244#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [9, 10]}}
{"token": ["This", "follow-up", "study", "analyzed", "the", "clinical", "profile", "C1838244#ent", "<e1>", "patients", "with", "C0004604#ent", "<e2>", "and", "evaluated", "the", "treatment", "outcome"], "h": {"id": "C1838244", "name": "C1838244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [11, 12]}}
{"token": ["C1336849#ent", "<e1>", "the", "substrate", "specificity", "protein", "ubiquitination", "subsequent", "C0208355#ent", "<e2>", "degradation", "."], "h": {"id": "C1336849", "name": "C1336849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0208355", "name": "C0208355#ent", "pos": [8, 9]}}
{"token": ["Subsequently", ",", "we", "have", "identified", "the", "C0017337#ent", "<e1>", "responsible", "for", "C1414558#ent", "<e2>", "on", "9q31", ",", "which", "encodes", "a", "novel", "461-amino-acid", "protein", "termed", "fukutin", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414558", "name": "C1414558#ent", "pos": [10, 11]}}
{"token": ["The", "C0017337#ent", "<e1>", "responsible", "for", "C1414558#ent", "<e2>", "was", "mapped", "to", "chromosome", "9q31", "a", "region", "in", "which", "convincing", "evidence", "of", "strong", "linkage", "disequilibrium", "C1414558#ent", "<e2>", "and", "mfd220", "(", "D9S306", ")", "was", "recently", "found", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414558", "name": "C1414558#ent", "pos": [5, 6]}}
{"token": ["This", "article", "reviews", "the", "clinical", "manifestations", "C0342546#ent", "<e1>", ",", "the", "biochemistry", "of", "the", "C0014442#ent", "<e2>", "involved", "in", "DHEA-S", "production", ",", "and", "the", "cell", "biology", "the", "adrenal", "zona", "reticularis"], "h": {"id": "C0342546", "name": "C0342546#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["The", "present", "study", "investigates", "enzyme", "activities", "the", "urea", "cycle", "C1530825#ent", "<e1>", "and", "ornithine-proline", "inter-conversion", "in", "the", "C0156259#ent", "<e2>", "unilateral", "nephrectomy", "mice", "."], "h": {"id": "C1530825", "name": "C1530825#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0156259", "name": "C0156259#ent", "pos": [16, 17]}}
{"token": ["Protein", "synthesis", "by", "bacteriophage", "lambdacI857S7drifd18", "in", "ultraviolet-irradiated", "cells", "indicates", "that", "L7/L12", ",", "As", "well", "as", "L1", ",", "L10", ",", "C1825519#ent", "<e1>", ",", "and", "possibly", "C1826469#ent", "<e2>", "or", "L9", "are", "coded", "by", "the", "phage", "DNA"], "h": {"id": "C1825519", "name": "C1825519#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1826469", "name": "C1826469#ent", "pos": [24, 25]}}
{"token": ["We", "investigated", "the", "effect", "of", "C0085387#ent", "<e1>", "the", "presence", "of", "C0012522#ent", "<e2>", "to", "determine", "if", "cyclo-oxygenase", "products", "contributing", "to", "the", "contraction", "beyond", "any", "effect", "they", "might", "have", "on", "histamine", "release", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012522", "name": "C0012522#ent", "pos": [10, 11]}}
{"token": ["PAK", "kinase", "and", "subcellular", "distribution", "are", "tightly", "regulated", "by", "rapid", "and", "transient", "localized", "Rac", "and", "C1366537#ent", "<e1>", "activation", ",", "and", "by", "interactions", "mediated", "by", "C1332163#ent", "<e2>"], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332163", "name": "C1332163#ent", "pos": [24, 25]}}
{"token": ["Here", ",", "we", "identified", "C1417172#ent", "<e1>", "as", "a", "new", "substrate", "of", "C0010656#ent", "<e2>", "and", "we", "characterized", "the", "cleavage", "site", "Asp", "345", "in", "the", "C-terminal", "domain"], "h": {"id": "C1417172", "name": "C1417172#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [11, 12]}}
{"token": ["The", "proapoptotic", "function", "gained", "by", "C1417172#ent", "<e1>", "following", "its", "processing", "by", "C0010656#ent", "<e2>", "provides", "a", "tissue-restricted", "means", "to", "modulate", "death", "in", "melanocyte", "and", "melanoma", "cells"], "h": {"id": "C1417172", "name": "C1417172#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [11, 12]}}
{"token": ["The", "quaternary", "structure", "stabilizes", "the", "coenzyme", "binding", "the", "protein", ";", "C0039847#ent", "<e1>", "split", "off", "from", "the", "C0282109#ent", "<e2>", "only", "upon", "destruction", "of", "the", "quaternary", "structure"], "h": {"id": "C0039847", "name": "C0039847#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0282109", "name": "C0282109#ent", "pos": [16, 17]}}
{"token": ["Evidence", "is", "presented", "that", "the", "use", "of", "C0242889#ent", "<e1>", "general", ",", "and", "C0031448#ent", "<e2>", "in", "particular", ",", "may", "predispose", "to", "this", "complication", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "it", "was", "not", "affected", "by", "the", "C0242889#ent", "<e1>", "propanolol", ",", "sotalol", "and", "C0031448#ent", "<e2>", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [15, 16]}}
{"token": ["The", "present", "study", "examined", "DC", "shifts", "induced", "by", "hyperventilation", "in", "healthy", "human", "subjects", "under", "the", "influence", "of", "the", "C3536850#ent", "<e1>", ",", "clonazepam", ",", "which", "is", "used", "as", "C0003286#ent", "<e2>", "."], "h": {"id": "C3536850", "name": "C3536850#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [27, 28]}}
{"token": ["The", "present", "study", "was", "performed", "to", "examine", "the", "effects", "of", "C0289313#ent", "<e1>", "treatment", "on", "C1420295#ent", "<e2>", "insulin", "sensitivity"], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [14, 15]}}
{"token": ["To", "assess", "whether", "neurons", "containing", "another", "isoform", "of", "nitric", "oxide", "synthase", "be", "present", "in", "the", "forebrain", "of", "normal", "rodents", ",", "we", "studied", "co-localization", "of", "C0023783#ent", "<e1>", "immunocytochemistry", "for", "C1533698#ent", "<e2>"], "h": {"id": "C0023783", "name": "C0023783#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [28, 29]}}
{"token": ["5", ")", "C0025810#ent", "<e1>", "is", "used", "as", "a", "psychostimulant", "in", "patients", "with", "C0027404#ent", "<e2>", "and", "children", "with", "attention-deficit", "disorder"], "h": {"id": "C0025810", "name": "C0025810#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0027404", "name": "C0027404#ent", "pos": [12, 13]}}
{"token": ["It", "is", "concluded", "that", "the", "TRH", "receptor", "regulates", "C0259479#ent", "<e1>", "GH3", "cell", "plasma", "membranes", "a", "GTP-dependent", "C1951340#ent", "<e2>", "."], "h": {"id": "C0259479", "name": "C0259479#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1951340", "name": "C1951340#ent", "pos": [16, 17]}}
{"token": ["Other", "muscarinic", "antagonists", "scopolamine", ",", "C0011785#ent", "<e1>", ",", "the", "M1", "muscarinic", "receptor", "antagonist", "pirenzepine", ",", "the", "C0019593#ent", "<e2>", "methoctramine", "and", "the", "M3", "receptor", "antagonist", "4-DAMP", "methiodide", "also", "inhibited", "5-hydroxytryptamine-induced", "inward", "current", "."], "h": {"id": "C0011785", "name": "C0011785#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [16, 17]}}
{"token": ["Functionality", "of", "the", "fusion", "proteins", "shown", "by", "transfection", "of", "human", "PEX3-", "and", "PEX19-deficient", "fibroblasts", "from", "C0043459#ent", "<e1>", "patients", "with", "tagged", "versions", "of", "PEX3", "and", "C1419147#ent", "<e2>", "."], "h": {"id": "C0043459", "name": "C0043459#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419147", "name": "C1419147#ent", "pos": [24, 25]}}
{"token": ["To", "review", "preclinical", "and", "clinical", "information", "C2709282#ent", "<e1>", ",", "an", "inhibitor", "of", "C0243045#ent", "<e2>", "CDKs", ")", ",", "tested", "as", "an", "antitumor", "agent"], "h": {"id": "C2709282", "name": "C2709282#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [12, 13]}}
{"token": ["The", "paper", "is", "especially", "concerned", "with", "the", "application", "of", "ABR", "to", "severe", "C0042075#ent", "<e1>", "children", "including", "central", "auditory", "dysfunction", "cerebral", "palsy", "infantile", "spasm", "adrenoleucodystrophy", ",", "anoxic", "brain", "damage", "C0013080#ent", "<e2>"], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013080", "name": "C0013080#ent", "pos": [28, 29]}}
{"token": ["C2984583#ent", "<e1>", "PAPPA", ")", "is", "a", "metzincin", "superfamily", "C1334706#ent", "<e2>", "in", "the", "insulin-like", "growth", "factor", "IGF", ")", "system", "."], "h": {"id": "C2984583", "name": "C2984583#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [8, 9]}}
{"token": ["Placentas", "were", "evaluated", "for", "evidence", "of", "C1300128#ent", "<e1>", ",", "chorioamnionitis", ",", "and", "C3898153#ent", "<e2>", "."], "h": {"id": "C1300128", "name": "C1300128#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3898153", "name": "C3898153#ent", "pos": [12, 13]}}
{"token": ["After", "7", "days", "C0011195#ent", "<e1>", "in", "the", "drinking", "water", "C0289313#ent", "<e2>", "lost", "significantly", "more", "weight", "than", "control", "mice"], "h": {"id": "C0011195", "name": "C0011195#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [9, 10]}}
{"token": ["Here", ",", "we", "present", "a", "detailed", "analysis", "of", "two", "new", "crystallographic", "forms", "RibH2", "that", "explain", "the", "low", "catalytic", "activity", "this", "C0027203#ent", "<e1>", "in", "comparison", "with", "RibH1", "and", "other", "C1851100#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1851100", "name": "C1851100#ent", "pos": [28, 29]}}
{"token": ["However", ",", "after", "beta", "1-blockade", "C0025859#ent", "<e1>", ",", "the", "resting", "C4307903#ent", "<e2>", "increased", "significantly", "during", "WI", "and", "resetting", "persisted", ",", "but", "the", "decrease", "of", "average", "gain", "was", "abolished", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4307903", "name": "C4307903#ent", "pos": [10, 11]}}
{"token": ["The", "authors", "examined", "C0019693#ent", "<e1>", "risk", "behaviors", "African", "American", "Asian/Pacific", "Islander", "API", ")", ",", "and", "Latina", "male-to-female", "C1539539#ent", "<e2>", ")", "transgender", "persons", "in", "order", "to", "improve", "C0019693#ent", "<e1>", "prevention", "programs"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539539", "name": "C1539539#ent", "pos": [17, 18]}}
{"token": ["To", "estimate", "C0019693#ent", "<e1>", "incidence", "among", "male-to-female", "transgendered", "persons", "(", "C1539539#ent", "<e2>", "transgendered", "persons", ")", "who", "repeatedly", "tested", "for", "HIV", "antibodies", "public", "San", "Francisco", "counseling", "and", "testing", "sites", "July", "1997", "and", "June", "2000", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539539", "name": "C1539539#ent", "pos": [10, 11]}}
{"token": ["C0812228#ent", "<e1>", "shows", "a", "weak", "association", "with", "C0393754#ent", "<e2>", "with", "stoichiometry", "close", "to", "that", "of", "RA", ",", "while", "interactions", "of", "RAL", "with", "C0393754#ent", "<e2>", "proceed", "non-specifically", "at", "multiple", "sites"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [7, 8]}}
{"token": ["Mutations", "in", "the", "CLN2", "gene", "which", "encodes", "a", "lysosomal", "serine", "protease", ",", "C0661884#ent", "<e1>", "TPP", "I", ",", "result", "in", "an", "autosomal", "recessive", "C0751870#ent", "<e2>", "children", ",", "classical", "late-infantile", "neuronal", "ceroid", "lipofuscinosis", "cLINCL", ")", "."], "h": {"id": "C0661884", "name": "C0661884#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [22, 23]}}
{"token": ["These", "results", "suggest", "that", "muscle", "fiber", "composition", "is", "linked", "to", "IR", "and", "that", "C0378675#ent", "<e1>", "may", "improve", "IR", "in", "C1412871#ent", "<e2>", "either", "by", "modulating", "muscle", "fiber", "composition", "or", "by", "increasing", "muscle", "blood", "flow"], "h": {"id": "C0378675", "name": "C0378675#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412871", "name": "C1412871#ent", "pos": [19, 20]}}
{"token": ["The", "transcriptional", "activity", "C0162508#ent", "<e1>", "was", "transiently", "enhanced", "by", "the", "treatment", "with", "C0054205#ent", "<e2>", "and", "this", "activation", "was", "suppressed", "by", "the", "expression", "of", "antisense", "mRNA", "for", "MAPK", "kinase-1"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0054205", "name": "C0054205#ent", "pos": [12, 13]}}
{"token": ["Our", "results", "provide", "an", "additional", "explanation", "for", "the", "mechanism", "underlying", "the", "actions", "of", "cyproheptadine", "as", "an", "C0003195#ent", "<e1>", "and", "an", "C0003417#ent", "<e2>"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003417", "name": "C0003417#ent", "pos": [20, 21]}}
{"token": ["C1822787#ent", "<e1>", "encodes", "a", "sporulation-specific", "mitogen-activated", "protein", "(", "MAP", ")", "C1334043#ent", "<e2>", "is", "required", "to", "regulate", "the", "postmeiotic", "events", "of", "spore", "wall", "assembly"], "h": {"id": "C1822787", "name": "C1822787#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}}
{"token": ["Although", "severe", "C4023018#ent", "<e1>", "old", "myocardial", "infarction", "moderate", "to", "severe", "C0003850#ent", "<e2>", "and", "decubitus", "of", "the", "back", "were", "also", "found", ",", "they", "were", "not", "considered", "primary", "cause", "of", "death", "."], "h": {"id": "C4023018", "name": "C4023018#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [10, 11]}}
{"token": ["The", "C0003211#ent", "<e1>", "studied", "included", "C0087097#ent", "<e2>", ",", "indomethacin", ",", "naproxen", ",", "and", "aspirin", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [1, 2]}, "relation": "structural_class_of", "t": {"id": "C0087097", "name": "C0087097#ent", "pos": [5, 6]}}
{"token": ["C1419987#ent", "<e1>", "proteins", "and", "proliferation", "activity", "their", "relationship", "with", "Epstein-Barr", "virus", "C0149678#ent", "<e2>", ")", "is", "a", "contemporary", "issue", "."], "h": {"id": "C1419987", "name": "C1419987#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [11, 12]}}
{"token": ["C1419987#ent", "<e1>", "not", "correlated", "with", "C0149678#ent", "<e2>", "."], "h": {"id": "C1419987", "name": "C1419987#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [5, 6]}}
{"token": ["The", "authors", "explored", "the", "neural", "substrate", "C0233763#ent", "<e1>", "dementia", "with", "Lewy", "bodies", "C0752347#ent", "<e2>", ")", "by", "investigating", "changes", "in", "regional", "cerebral", "blood", "flow", "rCBF", ")", "and", "psychiatric", "symptoms", "before", "and", "after", "cholinesterase", "inhibitor", "treatment", "."], "h": {"id": "C0233763", "name": "C0233763#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0752347", "name": "C0752347#ent", "pos": [12, 13]}}
{"token": ["In", "the", "presence", "of", "the", "C1517755#ent", "<e1>", "cytochalasin", "B", "optical", "forces", "for", "acropetal", "and", "basipetal", "displacement", "of", "C0005683#ent", "<e2>", "were", "significantly", "reduced", "to", "a", "similar", "level", "."], "h": {"id": "C1517755", "name": "C1517755#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005683", "name": "C0005683#ent", "pos": [17, 18]}}
{"token": ["We", "also", "show", "that", "Ly-49A", "directly", "associates", "with", "the", "C1384543#ent", "<e1>", "and", "that", "Ly-49A", "function", "is", "impaired", "in", "NK", "cells", "C1335283#ent", "<e2>", "mutant", "viable", "motheaten", "mice", "and", "from", "SHP-1-deficient", "motheaten", "mice", "."], "h": {"id": "C1384543", "name": "C1384543#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335283", "name": "C1335283#ent", "pos": [20, 21]}}
{"token": ["C1170407#ent", "<e1>", "is", "the", "C1254351#ent", "<e2>", "in", "an", "new", "FSA-approved", "OTC", "extended-release", "formulation", "."], "h": {"id": "C1170407", "name": "C1170407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}}
{"token": ["We", "examined", "the", "effect", "of", "C0815040#ent", "<e1>", "pH", "and", "hypoxia", "on", "the", "cytotoxicity", "of", "SR4233", "and", "C0026254#ent", "<e2>", "in", "vitro"], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [16, 17]}}
{"token": ["Multiple", "Endocrine", "Neoplasia", "type", "1", "MEN1", ")", "is", "an", "C0265336#ent", "<e1>", "OMIM", "131100", ")", "due", "to", "C1414395#ent", "<e2>", ",", "predisposing", "to", "the", "development", "of", "hyperplasic", "and", "tumoral", "lesions", "of", "neuroendocrine", "tissues"], "h": {"id": "C0265336", "name": "C0265336#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414395", "name": "C1414395#ent", "pos": [16, 17]}}
{"token": ["We", "have", "recently", "discovered", "that", "by", "inducing", "the", "activity", "of", "the", "C1332753#ent", "<e1>", "ATR", "and", "C0659150#ent", "<e2>", ",", "ARF", "neutralises", "this", "opposing", "pathway", "."], "h": {"id": "C1332753", "name": "C1332753#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0659150", "name": "C0659150#ent", "pos": [15, 16]}}
{"token": ["Tumor", "C1335278#ent", "<e1>", "as", "well", "as", "apoptosis-inducing", "effects", "C1332090#ent", "<e2>", "have", "been", "described", "."], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332090", "name": "C1332090#ent", "pos": [8, 9]}}
{"token": ["It", "was", "also", "observed", "that", "L-leucine-induced", "increases", "of", "cyclin/CDK", "expression", "were", "inhibited", "by", "C1709402#ent", "<e1>", "siRNA", "and", "ERK", "siRNA", ";", "C0281255#ent", "<e2>", "increased", "extracellular", "signal-regulated", "kinases", "1/2", "ERK1/2", ")", "and", "Akt", "phosphorylation", "levels", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0281255", "name": "C0281255#ent", "pos": [20, 21]}}
{"token": ["Unexpectedly", ",", "the", "antibiotics", "well", "characterized", "as", "C0007246#ent", "<e1>", "human", "pathogens", "such", "as", "tetracycline", "and", "C0282563#ent", "<e2>", ",", "showed", "bactericidal", "activity", "P.", "haemolytica", "and", "A.", "pleuropneumoniae"], "h": {"id": "C0007246", "name": "C0007246#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0282563", "name": "C0282563#ent", "pos": [15, 16]}}
{"token": ["C1710292#ent", "<e1>", "is", "released", "from", "platelet", "alpha-granules", "response", "to", "C0040018#ent", "<e2>"], "h": {"id": "C1710292", "name": "C1710292#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040018", "name": "C0040018#ent", "pos": [9, 10]}}
{"token": ["C0003864#ent", "<e1>", "a", "diverse", "group", "of", "C0221423#ent", "<e2>", "sharing", "the", "pathologic", "characteristic", "inflammation", "surrounding", "nerve", "fibers"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "C3889135#ent", "<e1>", "activators", "induce", "mRNA", "for", "the", "C3889135#ent", "<e1>", "target", "genes", ",", "C1455838#ent", "<e1>", "and", "the", "small", "heterodimer", "partner"], "h": {"id": "C3889135", "name": "C3889135#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1455838", "name": "C1455838#ent", "pos": [14, 15]}}
{"token": ["We", "have", "compared", "cells", "expressing", "only", "a", "mutated", "p89", "(", "xeroderma", "pigmentosum", "complementation", "group", "B", "C0268136#ent", "<e1>", "]", ")", ",", "the", "largest", "C1336616#ent", "<e2>", "with", "the", "same", "cells", "functionally", "complemented", "with", "the", "wild-type", "protein", "XPB/wt-p89", ")", "."], "h": {"id": "C0268136", "name": "C0268136#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1336616", "name": "C1336616#ent", "pos": [22, 23]}}
{"token": ["We", "have", "compared", "cells", "expressing", "only", "a", "mutated", "p89", "(", "C0268136#ent", "<e1>", "XPB", "]", ")", ",", "the", "largest", "C1336616#ent", "<e2>", "with", "the", "same", "cells", "functionally", "complemented", "with", "the", "wild-type", "protein", "XPB/wt-p89", ")", "."], "h": {"id": "C0268136", "name": "C0268136#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1336616", "name": "C1336616#ent", "pos": [18, 19]}}
{"token": ["i", ")", "SUG1", "interacts", "with", "C0268136#ent", "<e1>", "but", "not", "with", "the", "other", "core", "C1336616#ent", "<e2>", "the", "two-hybrid", "assay"], "h": {"id": "C0268136", "name": "C0268136#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336616", "name": "C1336616#ent", "pos": [13, 14]}}
{"token": ["C1425353#ent", "<e1>", "bound", "to", "Tti1", "interacts", "with", "various", "phosphatidyl", "inositol", "kinase", "kinases", "including", "C1336677#ent", "<e2>", ",", "Tra2", "and", "Rad3", ",", "as", "well", "as", "Tor1", "and", "Tor2", "."], "h": {"id": "C1425353", "name": "C1425353#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336677", "name": "C1336677#ent", "pos": [13, 14]}}
{"token": ["Increased", "expression", "of", "Sp1", "in", "a", "normal", "human", "fibroblast", "line", "a", "C1822773#ent", "<e1>", "promoter-luciferase", "construct", "resulted", "in", "a", "dose-dependent", "increase", "in", "C1334435#ent", "<e2>", "."], "h": {"id": "C1822773", "name": "C1822773#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334435", "name": "C1334435#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "the", "emphasis", "in", "treating", "C0034063#ent", "<e1>", "shifted", "from", "diuretics", "(", "ie", ",", "C0016860#ent", "<e2>", ")", "to", "vasodilators", "(", "ie", ",", "high-dose", "nitrates", "combined", "with", "noninvasive", "positive", "airway", "pressure", "ventilation", "rarely", "inotropes", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [14, 15]}}
{"token": ["These", "oligomers", "of", "C2827388#ent", "<e1>", "also", "displayed", "higher", "C0635005#ent", "<e2>", "activity", "than", "that", "of", "the", "monomer", "."], "h": {"id": "C2827388", "name": "C2827388#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0635005", "name": "C0635005#ent", "pos": [8, 9]}}
{"token": ["However", ",", "since", "the", "clinical", "and", "histologic", "features", "of", "hepatic", "injury", "methyldopa", "are", "indistinguishable", "from", "C0019159#ent", "<e1>", "it", "is", "suggested", "that", "the", "incidence", "of", "this", "C0020732#ent", "<e2>", "higher", "than", "generally", "appreciated", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020732", "name": "C0020732#ent", "pos": [25, 26]}}
{"token": ["In", "the", "C0209366#ent", "<e1>", "versus", "buserelin", "experiment", ",", "C0032002#ent", "<e2>", "of", "the", "GnRH", "receptor", "LH-beta", "subunit", "were", "significantly", "lower", "in", "C0209366#ent", "<e1>", "treated", "rats", "compared", "with", "controls", "whereas", "buserelin", "had", "little", "effect", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0209366", "name": "C0209366#ent", "pos": [2, 3]}}
{"token": ["Relatively", "few", "of", "the", "known", "viruses", "cause", "a", "significant", "number", "of", "deaths", ";", "influenza", ",", "childhood", "viral", "pneumonia", "and", "C0019159#ent", "<e1>", "are", "the", "only", "C0042769#ent", "<e2>", "more", "than", "1,000", "deaths", "per", "year", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [24, 25]}}
{"token": ["In", "a", "1-year", "prospective", "study", "1788", "cases", "of", "acute", "viral", "hepatitis", "26", "(", "1.5", "%", ")", "presented", "with", "evidence", "of", "simultaneous", "C0019159#ent", "<e1>", "HAV", ")", "and", "hepatitis", "B", "HBV", ")", "C0042769#ent", "<e2>"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [21, 22]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [30, 31]}}
{"token": ["GL", "inhibited", "C0019159#ent", "<e1>", "penetration", "of", "the", "plasma", "membrane", "measured", "by", "the", "amount", "of", "C0042769#ent", "<e2>", "longer", "neutralizable", "by", "specific", "antibody", "over", "time", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [14, 15]}}
{"token": ["The", "observed", "induction", "is", "consistent", "with", "previously", "reported", "expression", "of", "the", "nuclear", "receptors", "pregnane", "X", "receptor", "C1417827#ent", "<e1>", "and", "aryl", "hydrocarbon", "receptor", "which", "are", "necessary", "for", "a", "C0010762#ent", "<e2>", "induction", "response", "."], "h": {"id": "C1417827", "name": "C1417827#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [27, 28]}}
{"token": ["Recently", ",", "increased", "plasma", "homocysteine", "C0019880#ent", "<e1>", ")", "has", "been", "suggested", "as", "an", "independent", "risk", "factor", "C0521170#ent", "<e2>"], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0521170", "name": "C0521170#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "increased", "plasma", "homocysteine", "C0019880#ent", "<e1>", ")", "has", "been", "suggested", "as", "a", "novel", "independent", "risk", "factor", "C0521170#ent", "<e2>"], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0521170", "name": "C0521170#ent", "pos": [17, 18]}}
{"token": ["C0599208#ent", "<e1>", "PHK", ")", "is", "a", "key", "C0014442#ent", "<e2>", "in", "the", "control", "of", "glycogen", "breakdown"], "h": {"id": "C0599208", "name": "C0599208#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["In", "histoenzymatic", "studies", "changes", "in", "enzymatic", "activity", "NsE", ",", "C0234238#ent", "<e1>", ",", "ChE", ",", "AcP", ",", "C1706373#ent", "<e2>", "and", "TPPase", "were", "noted", "."], "h": {"id": "C0234238", "name": "C0234238#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [16, 17]}}
{"token": ["Following", "rapid", "isolation", ",", "it", "has", "been", "found", "that", "Golgi", "apparatus", "ethanol-intoxicated", "animals", "contain", "high", "levels", "of", "C0702242#ent", "<e1>", "but", "also", "detectable", "C0017755#ent", "<e2>", "and", "microsomal", "esterase", ",", "as", "well", "as", "5'-nucleotidase", "activity"], "h": {"id": "C0702242", "name": "C0702242#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [22, 23]}}
{"token": ["Ehrlich", "ascites", "tumour", "cells", "a", "higher", "specific", "activity", "of", "C0702242#ent", "<e1>", "and", "ouabain-sensitive", "(Na", ",", "K)ATPase", ",", "while", "liver", "cells", "higher", "C0017755#ent", "<e2>", ",", "5'-nucleotidase", "and", "succinate", "dehydrogenase", "activity", "."], "h": {"id": "C0702242", "name": "C0702242#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [21, 22]}}
{"token": ["C1412728#ent", "<e1>", "can", "also", "cleave", "C1537501#ent", "<e2>", "neurotensin", "but", "not", "bradykinin", "or", "15", "other", "vasoactive", "and", "hormonal", "peptides", "tested", "."], "h": {"id": "C1412728", "name": "C1412728#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "no", "difference", "C1512600#ent", "<e1>", "activities", "were", "seen", "between", "normal", "PBL", "and", "the", "C1254351#ent", "<e2>", "treated", "PBL", "cells", "."], "h": {"id": "C1512600", "name": "C1512600#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["The", "binding", "of", "C0245720#ent", "<e1>", ",", "a", "novel", "C0006683#ent", "<e2>", "to", "cytoplasmic", "membranes", "lipid", "vesicles", "been", "studied", "by", "means", "of", "its", "fluorescence", "."], "h": {"id": "C0245720", "name": "C0245720#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006683", "name": "C0006683#ent", "pos": [8, 9]}}
{"token": ["C0017668#ent", "<e1>", "C4049702#ent", "<e2>", ")", "recurs", "in", "30", "%", "of", "patients", "with", "C4049702#ent", "<e2>", "receiving", "a", "first", "renal", "transplant", "in", "over", "80", "%", "of", "patients", "receiving", "a", "second", "transplant", "after", "a", "recurrence", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C4049702", "name": "C4049702#ent", "pos": [2, 3]}}
{"token": ["Inhibition", "of", "C1419407#ent", "<e1>", ",", "induced", "by", "transfecting", "adenovirus", "vectors", "dominant-negative", "C1419407#ent", "<e1>", "into", "the", "NTS", ",", "decreased", "blood", "pressure", "heart", "rate", "and", "urinary", "C3887648#ent", "<e1>", "excretion", "in", "SHRSPs", "but", "not", "in", "Wistar-Kyoto", "rats", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [24, 25]}}
{"token": ["Finally", ",", "a", "B-Raf", "C1413723#ent", "<e1>", "mutant", "whose", "interaction", "with", "C1335590#ent", "<e2>", "is", "selectively", "enhanced", "was", "isolated", "and", "found", "to", "possess", "the", "double", "mutation", "K252E/M278", "T", "."], "h": {"id": "C1413723", "name": "C1413723#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335590", "name": "C1335590#ent", "pos": [10, 11]}}
{"token": ["C0669472#ent", "<e1>", "USP", ")", "are", "C0294105#ent", "<e2>", "remove", "ubiquitin", "from", "specific", "protein", "substrates", "and", "allow", "protein", "salvage", "proteasome", "degradation", ",", "regulation", "of", "protein", "localization", "activation", "."], "h": {"id": "C0669472", "name": "C0669472#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0294105", "name": "C0294105#ent", "pos": [5, 6]}}
{"token": ["A", "dominantly", "transmitted", "C0581384#ent", "<e1>", "by", "an", "increase", "of", "erythrocyte", "membrane", "phosphatidylcholine", "C3810569#ent", "<e2>", ")", "and", "cholesterol", "with", "decrease", "of", "phosphatidylethanolamine", "(", "PE", ")", "."], "h": {"id": "C0581384", "name": "C0581384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [12, 13]}}
{"token": ["No", "patient", "with", "C1420267#ent", "<e1>", "involvement", "had", "a", "prolonged", "SART", "or", "sick", "sinus", "syndrom", "C0037052#ent", "<e2>", ")", "."], "h": {"id": "C1420267", "name": "C1420267#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037052", "name": "C0037052#ent", "pos": [14, 15]}}
{"token": ["Neither", "C2827534#ent", "<e1>", "nor", "CZ112", "inhibit", "C0012920#ent", "<e2>", "thus", "are", "prodrugs", "dependent", "on", "hydrolysis", "to", "CPT", "or", "9NC", ",", "respectively", "."], "h": {"id": "C2827534", "name": "C2827534#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012920", "name": "C0012920#ent", "pos": [6, 7]}}
{"token": ["The", "cDNA", "microarray", "that", "genes", "for", "the", "TGF-beta", "pathway", "C0694889#ent", "<e1>", "were", "up-regulated", "in", "IGFBP-3-expressing", "C2697531#ent", "<e2>", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2697531", "name": "C2697531#ent", "pos": [15, 16]}}
{"token": ["The", "metabolite", "of", "C0051747#ent", "<e1>", ",", "C0666668#ent", "<e2>", ",", "displayed", "5", "-", "10", "times", "lower", "pharmacologic", "activity", "C0051747#ent", "<e1>", "."], "h": {"id": "C0666668", "name": "C0666668#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051747", "name": "C0051747#ent", "pos": [3, 4]}}
{"token": ["In", "conclusion", ",", "C0386394#ent", "<e1>", "treatment", "reduced", "systolic", "BP", "affecting", "glucose/insulin", "metabolism", "C0020480#ent", "<e2>", "conditions", "produced", "by", "cholesterol", "feeding"], "h": {"id": "C0386394", "name": "C0386394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020480", "name": "C0020480#ent", "pos": [12, 13]}}
{"token": ["A", "role", "for", "CCK", "in", "controlling", "C1539312#ent", "<e1>", "C1417815#ent", "<e2>", "expression", "is", "demonstrated", "by", "the", "down-regulation", "of", "C1539312#ent", "<e1>", "C1417815#ent", "<e2>", "by", "parenchymal", "DMH", "CCK", "administration", "in", "intact", "rats", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [6, 7]}}
{"token": ["Three", "long", "open", "reading", "frames", "identified", ";", "these", "C1412821#ent", "<e1>", "aspartokinase", "I", "dehydrogenase", "I", "(", "C1540075#ent", "<e2>", ")", ",", "homoserine", "kinase", "and", "threonine", "synthase", "in", "that", "order", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1540075", "name": "C1540075#ent", "pos": [15, 16]}}
{"token": ["The", "results", "of", "fractionation", "of", "nuclear", "DNA", "that", "m-AMSA", "induces", "20-", "to", "45-fold", "more", "DPC", "in", "C1824983#ent", "<e1>", "in", "the", "majority", "distal", "loop", "DNA", "supporting", "the", "notion", "that", "C0012863#ent", "<e2>", "located", "at", "the", "nuclear", "matrix"], "h": {"id": "C1824983", "name": "C1824983#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [28, 29]}}
{"token": ["Phytohaemagglutinin", "(", "PHA", ")", "induced", "lymphocyte", "transformation", "whole", "blood", "in", "purified", "lymphocyte", "cultures", "investigated", "in", "Gambian", "children", "with", "acute", "Plasmodium", "falciparum", "C0024530#ent", "<e1>", "or", "with", "acute", "protein-energy", "malnutrition", "C1417490#ent", "<e2>", ")", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1417490", "name": "C1417490#ent", "pos": [28, 29]}}
{"token": ["This", "enhancement", "was", "dependent", "upon", "concurrent", "up-regulation", "of", "SMC", "C1565860#ent", "<e1>", "expression", "and", "activity", "and", "was", "blocked", "by", "the", "C0085387#ent", "<e2>", "NS-398", "and", "Resveratrol", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [19, 20]}}
{"token": ["In", "MMDD1", "cells", ",", "a", "C1565860#ent", "<e1>", "inhibitor", "increased", "15-PGDH", ",", "whereas", "a", "C0085387#ent", "<e2>", "no", "effect"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [13, 14]}}
{"token": ["Taken", "together", ",", "our", "data", "suggest", "that", "C1705006#ent", "<e1>", "serves", "a", "protective", "role", "against", "C1096184#ent", "<e2>", "in", "part", ",", "by", "restricting", "replication", "in", "neurons", "."], "h": {"id": "C1705006", "name": "C1705006#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1096184", "name": "C1096184#ent", "pos": [14, 15]}}
{"token": ["Tumor", "necrosis", "factor-alpha", "receptor", "1", "signaling", "is", "vital", "for", "blood-brain", "barrier", "compromise", "upon", "C1705006#ent", "<e1>", "stimulation", "by", "dsRNA", "or", "C1096184#ent", "<e2>", "."], "h": {"id": "C1705006", "name": "C1705006#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1096184", "name": "C1096184#ent", "pos": [19, 20]}}
{"token": ["Of", "218", "patients", "with", "C0020538#ent", "<e1>", "who", "responded", "to", "monotherapy", "with", "C0032912#ent", "<e2>", "(", "Minipress", ")", "during", "the", "first", "3", "months", ",", "178", "persons", "completed", "the", "12-month", "treatment", "according", "to", "the", "study", "protocol"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [11, 12]}}
{"token": ["The", "anti-metastatic", "gene", "C0812204#ent", "<e1>", "was", "recently", "identified", "in", "murine", "and", "human", "C0029016#ent", "<e2>", "and", "the", "expressions", "of", "C0812204#ent", "<e1>", "mRNA", "and", "protein", "have", "been", "shown", "to", "be", "useful", "tumor", "invasion", "markers", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812204", "name": "C0812204#ent", "pos": [3, 4]}}
{"token": ["The", "effects", "of", "special", "balanced", "physiological", "saline", "C0231918#ent", "<e1>", "93", "patients", "with", "C0008711#ent", "<e2>", "studied", "."], "h": {"id": "C0231918", "name": "C0231918#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008711", "name": "C0008711#ent", "pos": [12, 13]}}
{"token": ["We", "examined", "whether", "brief", "exposures", "to", "moderately", "high", "concentrations", "of", "sulfur", "dioxide", "SO2", ")", "causes", "acute", "increases", "in", "C0231918#ent", "<e1>", "nasal", "resistance", "subjects", "with", "C0008711#ent", "<e2>"], "h": {"id": "C0231918", "name": "C0231918#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008711", "name": "C0008711#ent", "pos": [24, 25]}}
{"token": ["C0909381#ent", "<e1>", "was", "added", "to", "treat", "C0206178#ent", "<e2>"], "h": {"id": "C0909381", "name": "C0909381#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0206178", "name": "C0206178#ent", "pos": [6, 7]}}
{"token": ["and", "clenbuterol", ",", "as", "well", "as", "agents", "with", "anti-estrogenic", "activity", "tamoxifen", ",", "C0009008#ent", "<e1>", ")", ",", "drugs", "stimulating", "virility", "(", "sildenafil", ",", "C1176316#ent", "<e2>", ")", ",", "and", "unlabeled", "plastic", "bags"], "h": {"id": "C0009008", "name": "C0009008#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1176316", "name": "C1176316#ent", "pos": [22, 23]}}
{"token": ["Subsequently", ",", "we", "showed", "that", "C1367689#ent", "<e1>", "uPAR", ")", ",", "and", "matrix", "metalloproteinases", "C0623362#ent", "<e2>", ")", "1", "and", "2", "were", "critical", "in", "HIF-1alpha-induced", "invasion", "."], "h": {"id": "C1367689", "name": "C1367689#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [13, 14]}}
{"token": ["The", "cell", "surface", "expression", "of", "C1367689#ent", "<e1>", "and", "the", "activities", "of", "matrix", "metalloproteinase", "C0623362#ent", "<e2>", ")", "were", "assayed", "by", "flow", "cytometry", "FCM", ")", "and", "gelatin", "zymography", "respectively", "."], "h": {"id": "C1367689", "name": "C1367689#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [13, 14]}}
{"token": ["The", "adenosine", "A2", "receptor", "antagonist", "C0039763#ent", "<e1>", ",", "inhibited", "only", "the", "effect", "of", "the", "adenosine", "A2", "receptor", "C0243192#ent", "<e2>", "."], "h": {"id": "C0039763", "name": "C0039763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [17, 18]}}
{"token": ["Previous", "studies", "in", "our", "laboratories", "suggested", "a", "strong", "association", "between", "C1366496#ent", "<e1>", "(", "CYP19", ")", "gene", "expression", "the", "expression", "of", "C0033551#ent", "<e2>", "(", "COX", ")", "genes", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [20, 21]}}
{"token": ["A", "33-year-old", "woman", "with", "documented", "hypersensitivity", "to", "C0050537#ent", "<e1>", "ASA", ")", "and", "preservatives", ",", "causing", "C0004096#ent", "<e2>", "rhinitis", "when", "ingested", ",", "was", "investigated", "because", "of", "'", "allergy", "to", "nose", "drops", "."], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}}
{"token": ["A", "model", "of", "human", "C1332805#ent", "<e1>", "also", "built", "using", "coordinates", "of", "human", "C0007427#ent", "<e2>", "pig", "pepsinogen", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [12, 13]}}
{"token": ["Since", "cardiac", "tissue", "C1332805#ent", "<e1>", "a", "lysosomal", "enzyme", "of", "renin-like", "activity", ",", "a", "rat", "C0007427#ent", "<e2>", "also", "developed", "to", "assess", "C1332805#ent", "<e1>", "to", "renin-like", "activity", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [14, 15]}}
{"token": ["C0148517#ent", "<e1>", "less", "sensitive", "to", "and", "only", "partially", "inhibited", "by", "C1707322#ent", "<e2>", "and", "the", "analogs", "."], "h": {"id": "C0148517", "name": "C0148517#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1707322", "name": "C1707322#ent", "pos": [10, 11]}}
{"token": ["Because", "of", "the", "discrepancies", "in", "the", "specificity", "of", "C1412276#ent", "<e1>", ",", "we", "examined", "the", "sera", "of", "patients", "with", "DH", ",", "C0030807#ent", "<e2>", "and", "pemphigoid", "for", "C1412276#ent", "<e1>", "both", "by", "enzyme", "immunoassay", "by", "immunofluorescence", "."], "h": {"id": "C0030807", "name": "C0030807#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1412276", "name": "C1412276#ent", "pos": [8, 9]}}
{"token": ["C0033229#ent", "<e1>", ";", "haloperidol", ";", "diazepam", ";", "estazolam", ";", "C0029992#ent", "<e2>", "GABA", "transaminase", "inhibitor", ";", "phenoxybenzamine", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029992", "name": "C0029992#ent", "pos": [9, 10]}}
{"token": ["Multiple", "linear", "regression", "performed", "to", "identify", "the", "impact", "of", "CSF", "CRF", "and", "C1334081#ent", "<e1>", "concentrations", "upon", "the", "C0032002#ent", "<e2>", "CRF", "stimulation", "."], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [17, 18]}}
{"token": ["In", "the", "subset", "of", "patients", "with", "clinical", "evidence", "congestive", "heart", "failure", "99", "patients", ")", ",", "the", "prevalence", "of", "C1135196#ent", "<e1>", "38", "%", "and", "most", "patients", "had", "underlying", "coronary", "or", "C0020538#ent", "<e2>"], "h": {"id": "C1135196", "name": "C1135196#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [29, 30]}}
{"token": ["The", "integration", "cassettes", "comprise", "a", "single", "selectable", "yeast", "gene", "to", "a", "mammalian", "C1337114#ent", "<e1>", "either", "LEU2", "with", "neo", "or", "C1824940#ent", "<e2>", "with", "hol", "."], "h": {"id": "C1337114", "name": "C1337114#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1824940", "name": "C1824940#ent", "pos": [19, 20]}}
{"token": ["Kidney", "coimmunostaining", "with", "C1332813#ent", "<e1>", "and", "CD31", "Ab", "identified", "VACM-1-receptor", "expression", "in", "C0268731#ent", "<e2>", "and", "medullary", "vascular", "bundles"], "h": {"id": "C1332813", "name": "C1332813#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [12, 13]}}
{"token": ["Among", "the", "best", "characterized", "are", "the", "C1412481#ent", "<e1>", ",", "APOA4", ",", "APOB", ",", "APOC3", ",", "and", "C1416902#ent", "<e2>", "loci", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [16, 17]}}
{"token": ["The", "studied", "genes", "were", "C1412481#ent", "<e1>", ",", "APOB", ",", "APOC3", ",", "CETP", ",", "C1416902#ent", "<e2>", ",", "PON", ",", "MTHFR", ",", "FGB", ",", "GpIIIa", ",", "SELE", ",", "ACE", ",", "and", "AGT", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesized", "that", "endogenous", "ovarian", "estrogen", "exogenous", "E2beta", "treatment", "elevate", "expression", "of", "C1416870#ent", "<e1>", "eNOS", ")", "in", "C0567085#ent", "<e2>", ",", "but", "not", "in", "systemic", ",", "arteries", "."], "h": {"id": "C1416870", "name": "C1416870#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [17, 18]}}
{"token": ["Purified", "C0276475#ent", "<e1>", "retained", "its", "biological", "activity", "was", "capable", "of", "inhibiting", "C1706669#ent", "<e2>", "human", "T", "cells"], "h": {"id": "C0276475", "name": "C0276475#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706669", "name": "C1706669#ent", "pos": [11, 12]}}
{"token": ["The", "first", "clinically", "active", "drugs", "targeting", "a", "specific", "eye", "disease", "anticholinesterases", "(", "e.g.", "C0013530#ent", "<e1>", ")", "applied", "as", "eye", "drops", "treat", "C0017601#ent", "<e2>", "in", "the", "1960", "'s", "."], "h": {"id": "C0013530", "name": "C0013530#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [21, 22]}}
{"token": ["The", "mean", "clinical", "score", "for", "resting", "and", "postural", "tremor", "significantly", "decreased", "by", "long-acting", "C0033497#ent", "<e1>", "but", "not", "by", "primidone", "or", "C0009011#ent", "<e2>", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009011", "name": "C0009011#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "C1333718#ent", "<e1>", "which", "interacts", "with", "a", "distinct", "surface", "of", "C1705304#ent", "<e2>", "does", "not", "display", "this", "activity", "."], "h": {"id": "C1333718", "name": "C1333718#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "C1705304#ent", "<e1>", "is", "present", "in", "fractions", "with", "human", "C1333718#ent", "<e2>", "activity", ",", "and", "a", "proportion", "of", "C1705304#ent", "<e1>", "cofractionates", "with", "C1333718#ent", "<e2>", "over", "four", "chromatographic", "purification", "steps", "."], "h": {"id": "C1333718", "name": "C1333718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [2, 3]}}
{"token": ["Our", "unpublished", "data", "showed", "that", "the", "IE", "protein", "interacts", "with", "the", "same", "domain", "(", "aa", "125", "to", "174", ")", "of", "C1333718#ent", "<e1>", "and", "with", "C1705304#ent", "<e2>", "."], "h": {"id": "C1333718", "name": "C1333718#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [24, 25]}}
{"token": ["C0042085#ent", "<e1>", "man", "is", "responsible", "for", "C0162566#ent", "<e2>", "hepatoerythropoietic", "porphyria"], "h": {"id": "C0042085", "name": "C0042085#ent", "pos": [0, 1]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [6, 7]}}
{"token": ["AG1478", ",", "a", "specific", "inhibitor", "of", "EGFR", "C1335273#ent", "<e1>", ",", "inhibited", "ET-1-induced", "arachidonic", "acid", "release", "and", "C0082529#ent", "<e2>", "2", "(", "ERK1/2", ")", "."], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [16, 17]}}
{"token": ["Tacrine", "(", "1,2,3,4-tetrahydro-9-aminoacridine", ";", "C1564278#ent", "<e1>", ")", ",", "a", "reversible", "centrally", "acting", "C0008425#ent", "<e2>", ",", "has", "been", "shown", "to", "be", "potentially", "useful", "for", "treatment", "of", "patients", "with", "Alzheimer's", "disease"], "h": {"id": "C1564278", "name": "C1564278#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [12, 13]}}
{"token": ["The", "arene", "ligands", "flexibility", "through", "rotation", "around", "the", "arene-Ru", "pi-bonds", ",", "propeller", "twisting", "for", "C1415761#ent", "<e1>", ",", "and", "hinge-bending", "for", "THA", "and", "C2348308#ent", "<e2>", "."], "h": {"id": "C1415761", "name": "C1415761#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2348308", "name": "C2348308#ent", "pos": [22, 23]}}
{"token": ["In", "conclusion", ",", "chronic", "administration", "C0005116#ent", "<e1>", "but", "not", "of", "diltiazem", "prolongs", "ventricular", "repolarization", "patients", "with", "C0002962#ent", "<e2>"], "h": {"id": "C0005116", "name": "C0005116#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [16, 17]}}
{"token": ["The", "two", "C0086376#ent", "<e1>", "are", "targeting", "to", "early", "endosomal", "membranes", "interactions", "between", "C3541288#ent", "<e2>", "and", "activated", "(", "GTP-bound", ")", "Rab5", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541288", "name": "C3541288#ent", "pos": [12, 13]}}
{"token": ["The", "pharmacotherapy", "of", "prevention", "and", "treatment", "of", "acute", "altitude-", "related", "problems", "-", "acute", "C3887755#ent", "<e1>", "high-altitude", "cerebral", "oedema", "and", "C0034063#ent", "<e2>", "is", "reviewed", "."], "h": {"id": "C3887755", "name": "C3887755#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [19, 20]}}
{"token": ["Human", "C1417883#ent", "<e1>", "(", "hNUDT5", ")", "is", "an", "C0636347#ent", "<e2>", "ADPRase", ")", "belonging", "to", "the", "Nudix", "hydrolase", "superfamily"], "h": {"id": "C1417883", "name": "C1417883#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0636347", "name": "C0636347#ent", "pos": [8, 9]}}
{"token": ["Interestingly", ",", "C1424217#ent", "<e1>", "interacts", "with", "CASK", "(", "C0249866#ent", "<e2>", ",", "a", "member", "of", "the", "membrane-associated", "guanylate", "kinase", "MAGUK", ")", "family", "that", "plays", "important", "roles", "in", "the", "molecular", "organization", "proteins", "at", "synapses", "."], "h": {"id": "C1424217", "name": "C1424217#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0249866", "name": "C0249866#ent", "pos": [8, 9]}}
{"token": ["Neurofilaments", "(", "NFs", ")", ",", "composed", "of", "three", "distinct", "subunits", "NF-L", ",", "C2981621#ent", "<e1>", ",", "and", "NF-H", ",", "are", "C1414404#ent", "<e2>", "intermediate", "filaments", "in", "most", "mature", "neurons", "."], "h": {"id": "C2981621", "name": "C2981621#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414404", "name": "C1414404#ent", "pos": [19, 20]}}
{"token": ["In", "addition", "to", "Ca2", "+", "-dependent", "mediation", "of", "excitation-contraction", "coupling", "cardiac", "work", "C1705556#ent", "<e1>", "hydrolysis", ",", "Ca2", "+", "also", "stimulates", "the", "Krebs'", "cycle", "C1417088#ent", "<e2>", "maintain", "the", "nicotinamide", "adenine", "dinucleotide", "redox", "potential", "and", "C1705556#ent", "<e1>", "synthesis", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417088", "name": "C1417088#ent", "pos": [23, 24]}}
{"token": ["What", "follows", "is", "a", "selection", "of", "some", "of", "the", "limited", "contributions", "to", "C0155626#ent", "<e1>", "literature", "dealing", "with", "C0020550#ent", "<e2>", ",", "as", "well", "as", "the", "possible", "mechanisms", "described", "up", "to", "now", "."], "h": {"id": "C0155626", "name": "C0155626#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [17, 18]}}
{"token": ["C3810569#ent", "<e1>", "comprised", "52", "%", "of", "total", "C1705270#ent", "<e2>", "(", "39.6", "+", "/-", "1.9", "%", "in", "normal", "platelets", ")", "."], "h": {"id": "C3810569", "name": "C3810569#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705270", "name": "C1705270#ent", "pos": [7, 8]}}
{"token": ["Similarly", ",", "common", "complications", "of", "ocular", "inflammation", "as", "glaucoma", ",", "C0010803#ent", "<e1>", "precipitates", ",", "retinal", "(", "macular", ")", "C0013604#ent", "<e2>", "and", "neovascularization", "may", "be", "mediated", "by", "cytokines", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [18, 19]}}
{"token": ["Using", "a", "mouse", "model", "C3711370#ent", "<e1>", "to", "a", "null", "mutation", "the", "myelin", "C2698697#ent", "<e2>", "we", "find", "a", "progressive", "impairment", "in", "fast", "retrograde", "anterograde", "transport"], "h": {"id": "C3711370", "name": "C3711370#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2698697", "name": "C2698697#ent", "pos": [12, 13]}}
{"token": ["Pokeweed", "C0026249#ent", "<e1>", "(", "PWM", ")", "induced", "C3889643#ent", "<e2>", "responses", "of", "uraemic", "PBMC", "were", "also", "normal", ",", "whereas", "the", "response", "to", "another", "T", "cell", "B", "cell", "activator", "Staphylococcus", "aureus", "Cowan", "I", "SAC", ")", ",", "was", "very", "low", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889643", "name": "C3889643#ent", "pos": [7, 8]}}
{"token": ["Due", "to", "cellular", "dysfunction", "specific", "tissues", ",", "increases", "in", "C0795692#ent", "<e1>", "concentration", "in", "patients", "with", "severe", "C0243026#ent", "<e2>", "are", "not", "proof", "of", "tissue", "hypoxia"], "h": {"id": "C0795692", "name": "C0795692#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [16, 17]}}
{"token": ["The", "use", "of", "testosterone-replacement", "therapy", "the", "prevention", "and", "treatment", "of", "male", "osteoporosis", "remains", "controversial", "but", "likely", "to", "benefit", "C0521170#ent", "<e1>", "men", "with", "evident", "C0151721#ent", "<e2>", "."], "h": {"id": "C0521170", "name": "C0521170#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0151721", "name": "C0151721#ent", "pos": [23, 24]}}
{"token": ["The", "protein", "kinase", "the", "phosphorylation", "of", "casein", ",", "C3814454#ent", "<e1>", ",", "and", "the", "wheat", "germ", "C1420583#ent", "<e2>", "but", "not", "of", "bovine", "serum", "albumin", "and", "histones", "nor", "of", "the", "wheat", "germ", "protein", "CBP", "."], "h": {"id": "C3814454", "name": "C3814454#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420583", "name": "C1420583#ent", "pos": [15, 16]}}
{"token": ["CBP", "kinase", "catalyzes", "the", "phosphorylation", "of", "casein", ",", "C3814454#ent", "<e1>", ",", "CBP", ",", "and", "the", "wheat", "germ", "C1420583#ent", "<e2>", "."], "h": {"id": "C3814454", "name": "C3814454#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420583", "name": "C1420583#ent", "pos": [17, 18]}}
{"token": ["Two-hour", "exposure", "of", "O6-methylguanine", "at", "higher", "concentrations", "(", "500", "microM", ",", "1,000", "microM", ")", "increased", "C0771987#ent", "<e1>", "cytotoxicity", "by", "only", "2", "times", "in", "ACNU-resistant", "C1419009#ent", "<e2>", "-", "1", "brain", "tumour", "cells"], "h": {"id": "C0771987", "name": "C0771987#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419009", "name": "C1419009#ent", "pos": [24, 25]}}
{"token": ["The", "schizophrenic", "patients", "showed", "an", "increased", "concentration", "of", "GPC", "but", "not", "C1415376#ent", "<e1>", ",", "PE", "or", "C3811118#ent", "<e2>", "."], "h": {"id": "C1415376", "name": "C1415376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [16, 17]}}
{"token": ["The", "product", "was", "precipitable", "by", "C0600203#ent", "<e1>", "sensitive", "to", "C0011522#ent", "<e2>", ",", "but", "resistant", "to", "digestion", "by", "RNase", "."], "h": {"id": "C0600203", "name": "C0600203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [9, 10]}}
{"token": ["The", "use", "of", "C0040615#ent", "<e1>", "two", "disturbed", "C0751434#ent", "<e2>", "patients", "was", "studied", "over", "a", "period", "between", "4", "to", "5", "years", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751434", "name": "C0751434#ent", "pos": [7, 8]}}
{"token": ["Neurologists", "therefore", "must", "be", "aware", "of", "the", "underlying", "causes", ",", "pathophysiologic", "mechanisms", ",", "and", "potential", "interventions", "when", "encountering", "a", "patient", "with", "underlying", "C0027765#ent", "<e1>", "is", "also", "complaining", "of", "poor", "sleep", "C1950154#ent", "<e2>", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [30, 31]}}
{"token": ["C0027765#ent", "<e1>", "often", "associated", "with", "kinds", "of", "sleep", "disruption", "mainly", "C1950154#ent", "<e2>", ",", "less", "frequently", "hypersomnia", "or", "parasomnias", ")", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1950154", "name": "C1950154#ent", "pos": [10, 11]}}
{"token": ["Cerebroside", "and", "C0007804#ent", "<e1>", "were", "characterized", "by", "the", "absence", "of", "hydroxy", "and", "C1415068#ent", "<e2>", "numbered", "fatty", "acids", "and", "24:1", "acid", "was", "a", "predominant", "component", "of", "both", "glucocerebroside", "and", "galactocerebroside", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415068", "name": "C1415068#ent", "pos": [12, 13]}}
{"token": ["However", ",", "recently", ",", "inguinal", "lymph", "node-saphenous", "vein", "anastomosis", "and", "lymphangiovenous", "anastomosis", "the", "spermatic", "cord", "the", "lower", "C0030196#ent", "<e1>", "are", "introduced", "as", "a", "microsurgical", "treatment", "C0159075#ent", "<e2>", "with", "good", "result", "from", "China", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0159075", "name": "C0159075#ent", "pos": [25, 26]}}
{"token": ["The", "major", "diagnostic", "difficulty", "in", "distinguishing", "bone", "infection", "C0029443#ent", "<e1>", ")", "from", "non-infectious", "neuropathic", "bony", "disorders", "as", "in", "C0263661#ent", "<e2>", "Charcot", "foot", "."], "h": {"id": "C0029443", "name": "C0029443#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [18, 19]}}
{"token": ["C0029443#ent", "<e1>", "and", "osteonecrosis", "are", "C0263661#ent", "<e2>", "in", "patients", "with", "inflammatory", "bowel", "disease", "IBD", ")", "."], "h": {"id": "C0029443", "name": "C0029443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [5, 6]}}
{"token": ["The", "effects", "of", "methanol", ",", "butanol", ",", "glycerol", ",", "glucose", ",", "C1161331#ent", "<e1>", "and", "inorganic", "anions", "the", "activity", "of", "soluble", "C1706373#ent", "<e2>", "from", "mouse", "liver", "mitochondria", "were", "studied", "."], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [20, 21]}}
{"token": ["We", "recently", "provided", "evidence", "that", "C1839163#ent", "<e1>", "is", "caused", "by", "antibody", "binding", "to", "drug-induced", "conformational", "in", "C3811116#ent", "<e2>", "IIb/IIIa", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811116", "name": "C3811116#ent", "pos": [16, 17]}}
{"token": ["When", "APAS", "was", "associated", "with", "C1839163#ent", "<e1>", ",", "7/10", "patients", "possessed", "antibodies", "against", "GP", "IIb-IIIa", "C3811116#ent", "<e2>", "Ib-IX", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811116", "name": "C3811116#ent", "pos": [15, 16]}}
{"token": ["Alopecia", "(", "7", "%", ")", ",", "atopic", "dermatitis", "35", "%", ")", ",", "and", "C0677607#ent", "<e1>", "the", "most", "frequently", "reported", "conditions", ",", "but", "C0011847#ent", "<e2>", "and", "ulcerative", "colitis", "also", "observed", "."], "h": {"id": "C0677607", "name": "C0677607#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [22, 23]}}
{"token": ["Patients", "with", "HMSN", "who", "develop", "rapid", "progression", "of", "C0427055#ent", "<e1>", "should", "be", "evaluated", "for", "superimposed", ",", "potentially", "treatable", "C0027868#ent", "<e2>"], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [18, 19]}}
{"token": ["This", "C0003392#ent", "<e1>", "not", "due", "to", "an", "effect", "on", "C1417921#ent", "<e2>", "since", "its", "intracellular", "concentration", "was", "not", "significantly", "changed", "by", "agmatine", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417921", "name": "C1417921#ent", "pos": [9, 10]}}
{"token": ["We", "further", "demonstrated", "that", "C1705385#ent", "<e1>", "bound", "to", "both", "C1423842#ent", "<e2>", "and", "Th2", "cells", "according", "to", "flow", "cytometry", "and", "that", "the", "association", "was", "inhibited", "by", "soluble", "LIGHT", "."], "h": {"id": "C1705385", "name": "C1705385#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [9, 10]}}
{"token": ["Several", "C0949665#ent", "<e1>", "were", "also", "evaluated", "on", "P-gp-mediated", "efflux", "of", "(3)H", "C0010592#ent", "<e2>", "and", "14C", "erythromycin"], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}}
{"token": ["It", "is", "thus", "important", "to", "investigate", "the", "potential", "interaction", "between", "levofloxacin", ",", "a", "new", "C0949665#ent", "<e1>", "antimicrobial", "agent", "and", "the", "pharmacokinetics", "of", "C0010592#ent", "<e2>", "."], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [22, 23]}}
{"token": ["C0071997#ent", "<e1>", "is", "a", "C1305923#ent", "<e2>", "whereas", "C3", "secreted", "by", "cells", "in", "culture", "consists", "of", "two", "polypeptide", "chains", "mol", "wt", "120,000", "and", "76,000", ")", "linked", "by", "disulfide", "bonds"], "h": {"id": "C0071997", "name": "C0071997#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [4, 5]}}
{"token": ["We", "retrospectively", "investigated", "the", "long-term", "effects", "of", "C0527038#ent", "<e1>", "monotherapy", "on", "intraocular", "pressure", "visual", "field", "normal-tension", "glaucoma", "C0017612#ent", "<e2>", "patients", "."], "h": {"id": "C0527038", "name": "C0527038#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [17, 18]}}
{"token": ["To", "compare", "the", "efficacy", "and", "safety", "of", "latanoprost", "versus", "C0527038#ent", "<e1>", "unoprostone", ")", "in", "Japanese", "patients", "with", "C0017612#ent", "<e2>", "POAG", ")", "or", "ocular", "hypertension", "OH", ")", "."], "h": {"id": "C0527038", "name": "C0527038#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [17, 18]}}
{"token": ["Site-directed", "mutagenesis", "putative", "tyrosine", "phosphorylation", "sites", "C3539712#ent", "<e1>", "identified", "tyrosine", "39", "a", "C1307053#ent", "<e2>", "target", ",", "and", "a", "C3539712#ent", "<e1>", "with", "a", "mutated", "tyrosine", "39", "displayed", "an", "attenuated", "ability", "to", "bind", "COX-2", "mRNA", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539712", "name": "C3539712#ent", "pos": [6, 7]}}
{"token": ["Patients", "with", "high", "numbers", "of", "C1366837#ent", "<e1>", "positive", "PBMC", "tended", "to", "complicate", "C0024115#ent", "<e2>", "P", "less", "than", "0.005", ")", ",", "especially", "pulmonary", "fibrosis", "P", "less", "than", "0.005", ")", "."], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "absence", "of", "significant", "overexpression", "of", "C1414872#ent", "<e1>", "and", "FXR2", "in", "pathological", "brains", "suggests", "that", "these", "C0017337#ent", "<e2>", "do", "not", "compensate", "for", "the", "lack", "of", "FMR1", "expression", "."], "h": {"id": "C1414872", "name": "C1414872#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["Cathepsin", "D-like", "activity", "was", "measured", "in", "the", "sera", "of", "62", "patients", "with", "active", "systemic", "lupus", "erythematosus", "SLE", ")", ",", "9", "patients", "with", "progressive", "C0036421#ent", "<e1>", "9", "patients", "with", "C0017662#ent", "<e2>", "18", "with", "glomerulonephritis", "with", "nephrosis", "syndrome"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0017662", "name": "C0017662#ent", "pos": [28, 29]}}
{"token": ["The", "null", "mutant", "strains", "a", "25", "%", "reduction", "in", "C0008142#ent", "<e1>", "activity", "and", "were", "hypersensitive", "to", "C0108162#ent", "<e2>"], "h": {"id": "C0008142", "name": "C0008142#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0108162", "name": "C0108162#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "frequency", "of", "clinical", "manifestations", "biochemical", "and", "morphological", "alterations", "characteristic", "of", "liver", "affection", "patients", "with", "glutenic", "enteropathy", "C3539613#ent", "<e1>", ")", "in", "correlation", "with", "GE", "C2926735#ent", "<e2>", "and", "severity", "of", "malabsorption", "syndrome", "MAS", ")", "."], "h": {"id": "C3539613", "name": "C3539613#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [25, 26]}}
{"token": ["The", "applications", "of", "FP", "salivary", "diagnostics", "for", "determination", "of", "C0041323#ent", "<e1>", "exposure", "and", "of", "C0003175#ent", "<e2>", "immunization", "status", "are", "discussed", "as", "examples", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003175", "name": "C0003175#ent", "pos": [14, 15]}}
{"token": ["SAPK", ",", "a", "subfamily", "of", "the", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e1>", ",", "is", "a", "major", "C0010536#ent", "<e2>", "phosphorylates", "c-Jun", "and", "other", "transcription", "factors"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [16, 17]}}
{"token": ["These", "results", "indicate", "that", "down", "regulation", "of", "phorbol", "diester", "receptors", "is", "probably", "caused", "by", "nonlysosomal", "proteolysis", "of", "protein", "kinase", "C.", "C0031727#ent", "<e1>", "formed", "by", "cleavage", "may", "be", "an", "active", "catalytic", "site", "C0010536#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [31, 32]}}
{"token": ["We", "call", "attention", "to", "this", "particular", "and", "unusual", "skin", "manifestation", "C0023348#ent", "<e1>", "which", "can", "mimic", "C0035435#ent", "<e2>", "other", "causes", "of", "vasculitis", "."], "h": {"id": "C0023348", "name": "C0023348#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [15, 16]}}
{"token": ["C0064858#ent", "<e1>", "completely", "inhibited", "the", "loss", "of", "activity", "the", "three", "C3541394#ent", "<e2>", "in", "crude", "extracts", "improved", "yields", "when", "included", "in", "the", "grinding", "medium", "."], "h": {"id": "C0064858", "name": "C0064858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}}
{"token": ["Soybean", "trypsin", "inhibitor", "C0064858#ent", "<e1>", "inhibit", "both", "C3541394#ent", "<e2>", "to", "similar", "extent", "."], "h": {"id": "C0064858", "name": "C0064858#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}}
{"token": ["These", "data", "show", "that", "signal", "transduction", "C0257535#ent", "<e1>", "necessary", "for", "neutrophil", "chemotaxis", "that", "C1879974#ent", "<e2>", "intercedes", "through", "this", "pathway", "in", "inhibiting", "neutrophil", "movement", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1879974", "name": "C1879974#ent", "pos": [13, 14]}}
{"token": ["Some", "patients", "with", "immune", "complex", "C0012634#ent", "<e1>", "were", "identified", "with", "elevated", "C1421635#ent", "<e2>", "(", "up", "to", "24", "%", "TBV", "min-1", ")", "but", "without", "significant", "splenomegaly", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421635", "name": "C1421635#ent", "pos": [11, 12]}}
{"token": ["The", "C3815637#ent", "<e1>", "a", "member", "of", "the", "C3711161#ent", "<e2>", "ABC", ")", "transporter", "superfamily", "is", "involved", "in", "the", "cellular", "uptake", "tryptophan", "."], "h": {"id": "C3815637", "name": "C3815637#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3711161", "name": "C3711161#ent", "pos": [7, 8]}}
{"token": ["C1307407#ent", "<e1>", "controls", "a", "myriad", "of", "downstream", "effectors", ",", "including", "C0035678#ent", "<e2>", "S6K1", ",", "4E-BP1", ",", "and", "eEF2", "kinase", "."], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [10, 11]}}
{"token": ["In", "the", "carrageenan", "model", "of", "inflammatory", "pain", "systemic", "C1413968#ent", "<e1>", "or", "(1R,3R)3-MeGBP", "failed", "to", "inhibit", "C0020429#ent", "<e2>", "whereas", "(1S,3R)3-MeGBP", "had", "a", "significant", ",", "albeit", "transient", ",", "effect", "."], "h": {"id": "C1413968", "name": "C1413968#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [15, 16]}}
{"token": ["In", "patch-clamp", "experiments", ",", "C0031935#ent", "<e1>", ",", "veratridine", ",", "and", "nitrendipine", "blocked", "C1413043#ent", "<e2>", "+", "current", "through", "the", "slowly", "inactivating", "C1413043#ent", "<e2>", "+", "channels", "of", "GH4C1", "cells", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["Use", "of", "the", "C1413043#ent", "<e1>", "+", "channel", "blockers", "fluspirilene", "C0031935#ent", "<e2>", "and", "the", "C1413043#ent", "<e1>", "+", "chelator", "EGTA", "showed", "that", "C1413043#ent", "<e1>", "+", "was", "required", "for", "ABA", "induction", "of", "DGPP", "formation", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [3, 4]}}
{"token": ["The", "same", "conserved", "C2917660#ent", "<e1>", "also", "mutated", "in", "KVLQT1", "(", "C1416612#ent", "<e2>", ")", "in", "an", "LQT", "patient", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416612", "name": "C1416612#ent", "pos": [10, 11]}}
{"token": ["Tissue", "concentrations", "such", "agents", "have", "been", "previously", "determined", "in", "patients", "with", "C0009326#ent", "<e1>", "long-term", "treatment", "with", "acemetacin", "and", "C0021246#ent", "<e2>", "(", "K\u00f6hler", "et", "al.", ",", "1981", ")", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [18, 19]}}
{"token": ["The", "fact", "that", "C0039445#ent", "<e1>", "is", "an", "excellent", "substrate", "for", "C0044894#ent", "<e2>", "that", "C0039445#ent", "<e1>", "may", "have", "profound", "unrecognized", "biological", "actions", "and", "its", "inactivation", "may", "be", "via", "oxidation", "of", "the", "hydroxyl", "group"], "h": {"id": "C0039445", "name": "C0039445#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0044894", "name": "C0044894#ent", "pos": [10, 11]}}
{"token": ["Nebivolol", "prevented", "C0108855#ent", "<e1>", "activation", "without", "influencing", "p42mapk", ",", "C2827383#ent", "<e2>", "pRB", ",", "and", "p27Kip1", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [9, 10]}}
{"token": ["The", "preoperative", "workup", "including", "50", "clinical", "laboratory", "tests", "for", "C0009782#ent", "<e1>", "vasculitis", ",", "and", "C0037274#ent", "<e2>", "without", "pathological", "findings", ";", "more", "central", "embolic", "were", "excluded", "angio-", "and", "cardiologically", "."], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [14, 15]}}
{"token": ["Blood", "5-hydroxytryptamine", "levels", "were", "reduced", "during", "C0149931#ent", "<e1>", "attacks", "in", "patients", "who", "had", "taken", "C0014710#ent", "<e2>", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0014710", "name": "C0014710#ent", "pos": [14, 15]}}
{"token": ["Control", "and", "nephrotic", "rats", "were", "compared", "as", "to", "the", "C0023899#ent", "<e1>", "contents", "of", "cholesterol", ",", "phospholipid", "and", "the", "activity", "of", "C1415615#ent", "<e2>"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415615", "name": "C1415615#ent", "pos": [20, 21]}}
{"token": ["The", "nature", "of", "the", "protein", "phosphatases", "in", "the", "regulation", "of", "glycolysis/gluconeogenesis", ",", "fatty", "acid", "synthesis", "and", "cholesterol", "synthesis", "rat", "C0023899#ent", "<e1>", "has", "been", "investigated", "using", "L-pyruvate", "kinase", "ATP-citrate", "lyase", "acetyl-CoA", "carboxylase", "C1415615#ent", "<e2>", "substrates", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415615", "name": "C1415615#ent", "pos": [31, 32]}}
{"token": ["Rat", "C0023899#ent", "<e1>", "microsomes", "prepared", "in", "Tris", "buffer", "3", "to", "10", "times", "higher", "C1415615#ent", "<e2>", "activity", "than", "microsomes", "prepared", "with", "potassium", "phosphate", "buffer"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415615", "name": "C1415615#ent", "pos": [13, 14]}}
{"token": ["We", "report", "a", "6-month-old", "female", "infant", "with", "frequent", "brief", "C0036572#ent", "<e1>", "who", "subsequently", "showed", "C1836830#ent", "<e2>"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1836830", "name": "C1836830#ent", "pos": [14, 15]}}
{"token": ["The", "first", "was", "a", "32-year-old", "man", "with", "severe", "C1428834#ent", "<e1>", "his", "left", "leg", "was", "later", "diagnosed", "as", "C0036396#ent", "<e2>", "secondary", "to", "fifth", "lumbar-first", "sacral", "intervertebral", "disk", "herniation", "."], "h": {"id": "C1428834", "name": "C1428834#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036396", "name": "C0036396#ent", "pos": [17, 18]}}
{"token": ["Genetically", "determined", "deficiency", "of", "alpha-1-antitrypsin", ",", "the", "primary", "serum", "protease", "inhibitor", ",", "can", "result", "in", "pulmonary", "emphysema", "liver", "cirrhosis", "and", "C0030326#ent", "<e1>", "may", "be", "an", "C2985289#ent", "<e2>"], "h": {"id": "C0030326", "name": "C0030326#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2985289", "name": "C2985289#ent", "pos": [25, 26]}}
{"token": ["Initial", "baseline", "therapy", "C0026919#ent", "<e1>", "clarithromycin", ",", "rifampicin", ",", "ciprofloxacin", ",", "and/or", "C0014964#ent", "<e2>", "."], "h": {"id": "C0026919", "name": "C0026919#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0014964", "name": "C0014964#ent", "pos": [12, 13]}}
{"token": ["We", "previously", "generated", "a", "transgenic", "mouse", "model", "of", "pregnancy-associated", "hypertension", "C3203102#ent", "<e1>", ")", "via", "overproduction", "of", "angiotensin", "II", "an", "endogenous", "ligand", "of", "C1439284#ent", "<e2>", ",", "in", "the", "maternal", "circulation", "during", "late", "pregnancy"], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1439284", "name": "C1439284#ent", "pos": [22, 23]}}
{"token": ["We", "have", "prospectively", "studied", "the", "development", "of", "microangiopathic", "hemolysis", "C0034155#ent", "<e1>", "in", "patients", "undergoing", "intravascular", "stent", "for", "peripheral", "vascular", "C3640053#ent", "<e2>"], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3640053", "name": "C3640053#ent", "pos": [19, 20]}}
{"token": ["The", "mechanism", "appears", "to", "occur", "secondarily", "to", "stimulation", "of", "C3273483#ent", "<e1>", "turnover", "via", "C0031669#ent", "<e2>", "."], "h": {"id": "C3273483", "name": "C3273483#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [13, 14]}}
{"token": ["The", "C0101555#ent", "<e1>", "proteolytic", "system", "in", "reticulocytes", "can", "release", "the", "active", "hydrophilic", "domain", "cytochrome", "b5", "C1824843#ent", "<e2>", "the", "endoplasmic", "reticulum", "that", "in", "mature", "erythrocytes", "act", "as", "methemoglobin", "reductase"], "h": {"id": "C0101555", "name": "C0101555#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1824843", "name": "C1824843#ent", "pos": [15, 16]}}
{"token": ["They", "may", "be", "associated", "with", "C0014130#ent", "<e1>", "as", "Cushing's", "disease", "Addison's", "disease", "or", "C0020428#ent", "<e2>", ";", "however", "they", "are", "most", "often", "discovered", "incidentally", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0020428", "name": "C0020428#ent", "pos": [13, 14]}}
{"token": ["The", "C0027410#ent", "<e1>", "was", "deprenorphine", "(", "used", "with", "C0020197#ent", "<e2>", ")", "administered", "via", "the", "intramuscular", "route", "so", "that", "all", "animals", "in", "any", "group", "would", "recover", "more", "or", "less", "simultaneously", "."], "h": {"id": "C0027410", "name": "C0027410#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020197", "name": "C0020197#ent", "pos": [8, 9]}}
{"token": ["wt", "form", "of", "teleost", "(", "trout", ")", "C1412332#ent", "<e1>", "is", "a", "dimer", "composed", "of", "two", "85,000", "C0599220#ent", "<e2>", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}}
{"token": ["C1426677#ent", "<e1>", "decreases", "the", "expression", "of", "some", "T3", "sensitive", "C0017337#ent", "<e2>", "in", "various", "tissues", "and", "antagonizes", "the", "effect", "of", "T3", "on", "its", "nuclear", "receptors"], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["BFIS", "loci", "were", "identified", "on", "chromosomes", "19q12", "-", "13.1", "and", "16p12-q12", ",", "C0002085#ent", "<e1>", "to", "infantile", "convulsions", "and", "C0004158#ent", "<e2>", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004158", "name": "C0004158#ent", "pos": [18, 19]}}
{"token": ["C0063890#ent", "<e1>", "decrease", "the", "incidence", "of", "the", "C0021847#ent", "<e2>", "induced", "by", "vincristine", "in", "the", "rabbit", "."], "h": {"id": "C0063890", "name": "C0063890#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [7, 8]}}
{"token": ["HDHB", "proteins", "with", "mutations", "in", "the", "Walker", "A", "B", "motif", "ATPase", "and", "helicase", "activity", "retained", "the", "ability", "to", "interact", "with", "C0012888#ent", "<e1>", "suggesting", "that", "the", "mutants", "might", "be", "dominant", "over", "endogenous", "C1424812#ent", "<e2>", "in", "human", "cells"], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1424812", "name": "C1424812#ent", "pos": [31, 32]}}
{"token": ["It", "has", "recently", "become", "more", "clearly", "understood", "that", "in", "human", "brain", "pathophysiology", ",", "C0038317#ent", "<e1>", "play", "a", "role", "in", "anxiety", "disorders", "C0376356#ent", "<e2>", "postpartum", "depression", "posttraumatic", "stress", "disorder", "and", "depression", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0376356", "name": "C0376356#ent", "pos": [21, 22]}}
{"token": ["On", "day", "5", ",", "OVA", "+", "C1868193#ent", "<e1>", "increased", "the", "expression", "of", "most", "surface", "markers", "measured", "(", "MHC", "class", "II", "CD86", ",", "C3273109#ent", "<e2>", ",", "CD69", ")", "compared", "to", "OVA", "and", "C1868193#ent", "<e1>", "."], "h": {"id": "C3273109", "name": "C3273109#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1868193", "name": "C1868193#ent", "pos": [6, 7]}}
{"token": ["C0038013#ent", "<e1>", "a", "severe", "C0162323#ent", "<e2>", "requires", "long-term", "treatment", "with", "disease-modifying", "antirheumatic", "drugs"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162323", "name": "C0162323#ent", "pos": [4, 5]}}
{"token": ["Another", "active", "compound", "C0297253#ent", "<e1>", "extracted", "from", "Centella", "asiatica", "known", "to", "induce", "C0009325#ent", "<e2>", "expression", "and/or", "to", "modulate", "inflammatory", "mediators", "might", "thus", "prevent", "and", "correct", "some", "signs", "of", "ageing", "."], "h": {"id": "C0297253", "name": "C0297253#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "only", "C0297253#ent", "<e1>", "was", "able", "to", "increase", "significantly", "C0009325#ent", "<e2>", "secretion", "."], "h": {"id": "C0297253", "name": "C0297253#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [10, 11]}}
{"token": ["C0334013#ent", "<e1>", "be", "triggered", "by", "a", "relative", "deficiency", "linoleic", "acid", "C3539984#ent", "<e2>", "from", "sebum", "components", ",", "and", "especially", "by", "inflammatory", "mediators", "as", "interleukin-1", "."], "h": {"id": "C0334013", "name": "C0334013#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539984", "name": "C3539984#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "present", "work", "was", "to", "study", "the", "systemic", "inflammatory", "reaction", "judged", "by", "complement", "activation", "C1333196#ent", "<e1>", "and", "chemokines", "release", "in", "patients", "with", "C0025064#ent", "<e2>", "after", "open", "heart", "operation"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0025064", "name": "C0025064#ent", "pos": [25, 26]}}
{"token": ["The", "expression", "of", "the", "constitutive", "synthesis", "enzyme", "C1415652#ent", "<e1>", "was", "diminished", ",", "and", "the", "expression", "of", "C1415699#ent", "<e2>", "the", "key", "enzyme", "catabolizing", "PGs", ",", "was", "increased", "in", "treated", "tumors", "."], "h": {"id": "C1415652", "name": "C1415652#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415699", "name": "C1415699#ent", "pos": [16, 17]}}
{"token": ["After", "removal", "of", "the", "C0026249#ent", "<e1>", "stimulus", "from", "the", "T-cell", "cultures", "C1705281#ent", "<e2>", "expression", "is", "downregulated", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [11, 12]}}
{"token": ["C1420214#ent", "<e1>", "mRNA", "hybridization", "signal", "in", "the", "dorsal", "raphe", "nucleus", "only", "slightly", "reduced", "after", "C0000543#ent", "<e2>", "."], "h": {"id": "C1420214", "name": "C1420214#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000543", "name": "C0000543#ent", "pos": [14, 15]}}
{"token": ["C1420214#ent", "<e1>", "was", "abolished", "by", "pretreatment", "with", "the", "serotonin", "neurotoxin", "C0000543#ent", "<e2>", "."], "h": {"id": "C1420214", "name": "C1420214#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000543", "name": "C0000543#ent", "pos": [10, 11]}}
{"token": ["Children", "with", "C0019061#ent", "<e1>", "present", "with", "gastroenteritis", "complaints", "e.g.", ",", "C0000737#ent", "<e2>", "tenderness", ",", "nausea", "or", "vomiting", ",", "fever", ",", "anemia", ")", ";", "affected", "adults", "may", "be", "asymptomatic", "."], "h": {"id": "C0019061", "name": "C0019061#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [10, 11]}}
{"token": ["In", "vitro", "binding", "affinities", "of", "six", "compounds", ",", "clorgyline", ",", "Ro", "41", "-", "1049", ",", "C0086130#ent", "<e1>", ",", "fluoxetine", ",", "norfluoxetine", "and", "C0724555#ent", "<e2>", ",", "were", "studied", "."], "h": {"id": "C0086130", "name": "C0086130#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0724555", "name": "C0724555#ent", "pos": [22, 23]}}
{"token": ["This", "modification", "has", "been", "used", "as", "a", "marker", "to", "identify", "with", "C0072074#ent", "<e1>", "and", "imaging", "MALDI-ToF", "MS", "areas", "in", "sections", "of", "an", "mdx", "mouse", "C0023218#ent", "<e2>"], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023218", "name": "C0023218#ent", "pos": [24, 25]}}
{"token": ["No", "significant", "increase", "in", "plasma", "C1417807#ent", "<e1>", "was", "observed", "in", "patients", "with", "nephrotic", "syndrome", "C1561643#ent", "<e2>", "to", "healthy", "volunteers"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [14, 15]}}
{"token": ["We", "measured", "plasma", "levels", "of", "immunoreactive", "human", "C1417807#ent", "<e1>", "ANF", ")", "in", "C1561643#ent", "<e2>", "patients", "treated", "by", "hemodialysis", "(", "HD", ")", "and", "continuous", "ambulatory", "peritoneal", "dialysis", "CAPD", ")", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [12, 13]}}
{"token": ["Incontinentia", "pigmenti", "C1419070#ent", "<e1>", ")", "is", "a", "C0037277#ent", "<e2>", ",", "which", "is", "of", "X-linked", "dominant", ",", "uncommonly", "diagnosed", "in", "newborn", "babies"], "h": {"id": "C1419070", "name": "C1419070#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [7, 8]}}
{"token": ["Incontinentia", "pigmenti", "C1419070#ent", "<e1>", ")", "is", "an", "unusual", "C0037277#ent", "<e2>", "occurring", "almost", "exclusively", "in", "female", "patients", "."], "h": {"id": "C1419070", "name": "C1419070#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [8, 9]}}
{"token": ["C0030557#ent", "<e1>", "and", "selegiline", "selectively", "inhibited", "brain", "C0026455#ent", "<e2>", "and", "MAO-B", "activity", "(", "by", "more", "than", "90", "%", ")", ",", "resp", "."], "h": {"id": "C0030557", "name": "C0030557#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026455", "name": "C0026455#ent", "pos": [7, 8]}}
{"token": ["Treatment", "of", "MBECs", "with", "recombinant", "human", "C1414438#ent", "<e1>", "(", "rhEPO", ")", "significantly", "increased", "secretion", "of", "matrix", "metalloproteinase", "2", "C0172537#ent", "<e2>", ")", "and", "MMP9", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [18, 19]}}
{"token": ["The", "effect", "of", "C0893761#ent", "<e1>", "was", "equal", "or", "even", "superior", "to", "C0033497#ent", "<e2>", "and", "primidone", "indicating", "that", "C0893761#ent", "<e1>", "may", "be", "a", "new", "antitremorgenic", "drug", "that", "merits", "further", "clinical", "investigation", "."], "h": {"id": "C0893761", "name": "C0893761#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [11, 12]}}
{"token": ["Follicle-stimulating", "hormone", "receptor", "C2986690#ent", "<e1>", ")", "is", "a", "glycoprotein", "hormone", "receptor", "possesses", "a", "large", "extracellular", "domain", "C1825023#ent", "<e2>", ")", "instrumental", "in", "hormone", "binding"], "h": {"id": "C2986690", "name": "C2986690#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1825023", "name": "C1825023#ent", "pos": [16, 17]}}
{"token": ["As", "shown", "in", "placebo-controlled", "trials", "C0015620#ent", "<e1>", "is", "effective", "in", "healing", "both", "duodenal", "and", "C0038358#ent", "<e2>"], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [14, 15]}}
{"token": ["To", "compare", "the", "efficacy", "of", "lansoprazole", "and", "C0015620#ent", "<e1>", "in", "the", "treatment", "of", "C0038358#ent", "<e2>", "24", "patients", "with", "C0038358#ent", "<e2>", "treated", "for", "8", "weeks", "."], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [13, 14]}}
{"token": ["Among", "blockers", "of", "the", "IK", "channel", "also", "several", "small", "organic", "molecules", "the", "C0009074#ent", "<e1>", "the", "close", "analogues", "C0916207#ent", "<e2>", "and", "ICA-17043", ",", "as", "well", "as", "the", "antihypertensive", ",", "nitrendipine", "."], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0916207", "name": "C0916207#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "the", "dominant", "GTPase-deficient", "gip2", "polypeptide", "will", "constitutively", "inhibit", "adenylylcyclase", "but", "differentially", "modulate", "C3540772#ent", "<e1>", "regulated", "by", "calcium", "and", "coupled", "to", "C1825938#ent", "<e2>", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1825938", "name": "C1825938#ent", "pos": [22, 23]}}
{"token": ["These", "studies", "suggest", "that", "hypothalamic", "cells", "culture", "release", "C1418549#ent", "<e1>", "active", "sodium", "transport", "increases", "vascular", "reactivity", "potentiates", "C4255305#ent", "<e2>", "effects", "of", "noradrenaline", "and", "causes", "calcium", "retention"], "h": {"id": "C1418549", "name": "C1418549#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [17, 18]}}
{"token": ["Habit", "reversal", "to", "be", "more", "effective", "in", "reducing", "the", "C0553642#ent", "<e1>", "symptoms", "of", "C0039494#ent", "<e2>", "than", "in", "improving", "temporomandibular", "joint", "functioning"], "h": {"id": "C0553642", "name": "C0553642#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039494", "name": "C0039494#ent", "pos": [13, 14]}}
{"token": ["The", "role", "of", "the", "major", "C3641873#ent", "<e1>", "CYP", ")", "enzymes", "as", "well", "as", "P-glycoprotein", "(", "C1422070#ent", "<e2>", ")", "was", "investigated", "in", "the", "disposition", "of", "ketobemidone", "in", "vitro"], "h": {"id": "C3641873", "name": "C3641873#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [15, 16]}}
{"token": ["Searches", "at", "databases", "comparing", "the", "sequence", "of", "amino", "acids", "the", "three", "C0030956#ent", "<e1>", "of", "the", "native", "protein", "revealed", "strong", "homology", "to", "triosephosphate", "isomerase", "C3541335#ent", "<e2>", ":", "E.C.", "5.3.1.1", "from", "several", "sources", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3541335", "name": "C3541335#ent", "pos": [23, 24]}}
{"token": ["Members", "of", "this", "group", "have", "been", "shown", "to", "be", "adhesins", ",", "and", "we", "hypothesize", "that", "C1414527#ent", "<e1>", "may", "function", "as", "an", "adhesin", "in", "C0014118#ent", "<e2>", "."], "h": {"id": "C1414527", "name": "C1414527#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [23, 24]}}
{"token": ["injection", "of", "C0040961#ent", "<e1>", "into", "sensitized", "mice", "did", "not", "inhibit", "C0007965#ent", "<e2>", ",", "although", "injection", "of", "C0040961#ent", "<e1>", "into", "the", "ears", "of", "sensitized", "mice", "suppressed", "the", "challenge", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [2, 3]}}
{"token": ["JMML", "arises", "from", "clonal", "expansion", "a", "hematopoietic", "stem", "cell", "and", "JMML", "cells", "and", "murine", "Nf1-/-", "hematopoietic", "cells", "are", "hypersensitive", "to", "granulocyte", "macrophage-colony", "stimulating", "factor", "C1704887#ent", "<e1>", ",", "the", "ligand", "for", "C1704888#ent", "<e2>", "."], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1704888", "name": "C1704888#ent", "pos": [30, 31]}}
{"token": ["32D", "cells", "a", "murine", "IL-3-dependent", "myeloid", "cell", "line", ",", "were", "rendered", "C1704887#ent", "<e1>", "responsive", "by", "transfection", "of", "the", "murine", "C1704888#ent", "<e2>", "."], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704888", "name": "C1704888#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "apoptosis", "induced", "by", "NGEN", "via", "the", "activation", "of", "C1417708#ent", "<e1>", "and", "necrosis", "involving", "the", "loss", "of", "C1705556#ent", "<e2>", "in", "human", "promyeloleukemia", "HL-60", "cells"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [23, 24]}}
{"token": ["Several", "C0017337#ent", "<e1>", "were", "newly", "identified", "as", "members", "of", "the", "C1367595#ent", "<e2>", "and", "NifA", "regulons", ",", "beyond", "C0017337#ent", "<e1>", ",", "which", "had", "been", "known", "from", "previous", "work", "."], "h": {"id": "C1367595", "name": "C1367595#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}}
{"token": ["C2348502#ent", "<e1>", ",", "in", "turn", ",", "inhibited", "C1335876#ent", "<e2>", "by", "a", "novel", "mechanism", "that", "leads", "to", "suppression", "of", "GH-inducible", "STAT5b", "tyrosine", "phosphorylation", ",", "DNA", "binding", "activity", "and", "transcriptional", "activity"], "h": {"id": "C2348502", "name": "C2348502#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335876", "name": "C1335876#ent", "pos": [7, 8]}}
{"token": ["Nine", "infertile", "patients", ",", "suffering", "from", "C0032460#ent", "<e1>", "were", "treated", "with", "human", "urinary", "C0016424#ent", "<e2>", "and", "hCG", "(", "eight", "cases", ")", "to", "induce", "ovulation", "."], "h": {"id": "C0032460", "name": "C0032460#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [13, 14]}}
{"token": ["From", "the", "clinical", "point", "of", "view", "clinicians", "nowadays", "tend", "to", "stimulate", "C0032460#ent", "<e1>", "patients", "with", "recombinant", "C0016424#ent", "<e2>", "plus", "the", "application", "of", "GnRH", "analogs", "in", "a", "long", "protocol"], "h": {"id": "C0032460", "name": "C0032460#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [16, 17]}}
{"token": ["Sixteen", "infertile", "women", "with", "the", "C0032460#ent", "<e1>", "treated", "using", "stimulation", "of", "ovulation", "with", "purified", "C0016424#ent", "<e2>", "after", "Clomid", "had", "failed", "."], "h": {"id": "C0032460", "name": "C0032460#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "replacement", "of", "the", "C-terminal", "sequence", "C1705526#ent", "<e1>", "with", "that", "of", "C1453853#ent", "<e2>", "increased", "the", "affinity", "of", "the", "chimera", "for", "MDM2", "by", "1.1", "kcal", "mol(-1", ")", ",", "contrary", "to", "expectations", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1453853", "name": "C1453853#ent", "pos": [13, 14]}}
{"token": ["C0162566#ent", "<e1>", "usually", "precipitated", "by", "C0001962#ent", "<e2>", ",", "oestrogens", ",", "hepatitis", "viruses", "HIV", "or", "haemodialysis", "."], "h": {"id": "C0162566", "name": "C0162566#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [5, 6]}}
{"token": ["This", "enzyme", "preparation", "could", "dephosphorylate", "both", "the", "C0081889#ent", "<e1>", "as", "well", "as", "the", "cAMP-dependent", "sites", "on", "C1418650#ent", "<e2>", "."], "h": {"id": "C0081889", "name": "C0081889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418650", "name": "C1418650#ent", "pos": [16, 17]}}
{"token": ["To", "understand", "the", "role", "of", "C0694888#ent", "<e1>", "in", "regulating", "cell", "proliferation", "apoptosis", ",", "we", "stably", "C3889446#ent", "<e2>", "C0694888#ent", "<e1>", "in", "PC3", "cells", "which", "are", "prostate", "cancer", "cells", "that", "lack", "C0694888#ent", "<e1>", "."], "h": {"id": "C0694888", "name": "C0694888#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [15, 16]}}
{"token": ["The", "C1414250#ent", "<e1>", "the", "corneal", "endothelium", "identified", "in", "cases", "of", "C0339284#ent", "<e2>", "assumed", "to", "be", "specific", "for", "this", "entity", "."], "h": {"id": "C1414250", "name": "C1414250#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0339284", "name": "C0339284#ent", "pos": [10, 11]}}
{"token": ["Our", "previous", "studies", "and", "those", "of", "others", "indicated", "that", "the", "C3813181#ent", "<e1>", "C1825463#ent", "<e2>", ")", "is", "a", "tumor", "suppressor", "cyclin-dependent", "kinase", "inhibitor", "and", "that", "these", "C1825463#ent", "<e2>", "functions", "are", "mainly", "dependent", "on", "its", "C-terminal", "region"], "h": {"id": "C3813181", "name": "C3813181#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1825463", "name": "C1825463#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "despite", "the", "identification", "of", "lymphatic", "endothelial", "cell", "C1418643#ent", "<e1>", ")", "markers", "such", "as", "Prox1", ",", "podoplanin", ",", "C3273328#ent", "<e2>", ",", "and", "VEGFR-3", ",", "no", "activation", "marker", "tumor-associated", "LECs", "has", "been", "identified", "."], "h": {"id": "C1418643", "name": "C1418643#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273328", "name": "C3273328#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "indicate", "C0033681#ent", "<e1>", "activation", "participates", "in", "IL-1", "beta-induced", "expression", "of", "C1417760#ent", "<e2>", "by", "the", "insulin-secreting", "beta-cell.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [12, 13]}}
{"token": ["The", "results", "demonstrated", "the", "involvement", "of", "[Ca(2+)]i", ",", "C0033681#ent", "<e1>", "inflammatory", "cytokines", "and", "NF-kappaB", "in", "CYP1A1-mediated", "C1417760#ent", "<e2>", "expression", "in", "benzo(a)pyrene-treated", "rat", "PMNs", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "a", "series", "of", "peptide", "inhibitors", "designed", "and", "synthesized", "based", "on", "the", "C-terminal", "fragment", "histone", "C1415386#ent", "<e1>", ",", "which", "has", "an", "inhibitory", "effect", "on", "C0919550#ent", "<e2>", "."], "h": {"id": "C1415386", "name": "C1415386#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [27, 28]}}
{"token": ["Our", "results", "suggest", "that", "C3538717#ent", "<e1>", ",", "in", "cooperation", "with", "C3899313#ent", "<e2>", ",", "antagonizes", "the", "DAF-2", "insulin-like", "signaling", "pathway", "modulate", "interneuron", "activity", "required", "for", "food-associated", "integrative", "behavior"], "h": {"id": "C3538717", "name": "C3538717#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3899313", "name": "C3899313#ent", "pos": [10, 11]}}
{"token": ["Celtix-1", "directly", "interacts", "with", "C1708450#ent", "<e1>", "based", "on", "binding", "studies", "with", "C1415329#ent", "<e2>", "fusion", "proteins", "and", "immunofluorescence", "studies", "that", "Celtix-1", "and", "C1708450#ent", "<e1>", "associate", "in", "situ"], "h": {"id": "C1708450", "name": "C1708450#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415329", "name": "C1415329#ent", "pos": [11, 12]}}
{"token": ["C0004057#ent", "<e1>", ",", "sulfinpyrazone", ",", "and", "most", "other", "C0003211#ent", "<e2>", "platelet", "function", "inhibiting", "the", "activity", "of", "cyclooxygenase", ",", "an", "enzyme", "necessary", "for", "the", "production", "of", "prostaglandins", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [8, 9]}}
{"token": ["C0004057#ent", "<e1>", "and", "other", "nonsteroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e2>", ")", "can", "produce", "a", "mild", ",", "systemic", "hemostatic", "defect", "inhibiting", "normal", "platelet", "function"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [7, 8]}}
{"token": ["Vinca", "alkaloids", "including", "vinblastine", ",", "vincristine", ",", "C0042682#ent", "<e1>", "and", "vinorelbine", ",", "are", "widely", "used", "C0282559#ent", "<e2>", "either", "as", "single", "agents", "in", "combination", "with", "other", "drugs", "."], "h": {"id": "C0042682", "name": "C0042682#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0282559", "name": "C0282559#ent", "pos": [15, 16]}}
{"token": ["The", "relative", "expression", "of", "C1706006#ent", "<e1>", "mRNA", "compared", "with", "that", "of", "C1384510#ent", "<e2>", "was", "established", "by", "semi-quantitative", "RT-PCR", "."], "h": {"id": "C1706006", "name": "C1706006#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1384510", "name": "C1384510#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "immunologic", "profiles", "preterm", "infants", "sepsis", ",", "using", "chemokine", "and", "C1333196#ent", "<e1>", "measurements", "to", "predict", "the", "development", "of", "sepsis-induced", "C0010927#ent", "<e2>", "at", "the", "onset", "of", "infection", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [21, 22]}}
{"token": ["In", "an", "open", ",", "randomized", ",", "parallel", "group", "study", "8", "weeks", ",", "nine", "males", "and", "nine", "females", "with", "C0018801#ent", "<e1>", "initially", "treated", "daily", "20", "mg", "frusemide/2.5", "mg", "C0546849#ent", "<e2>", "or", "0.5", "mg", "bumetanide/573", "mg", "potassium", "chloride"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [27, 28]}}
{"token": ["Captopril", "alone", "as", "therapy", "for", "C0018801#ent", "<e1>", "compared", "with", "a", "combination", "of", "frusemide", "and", "C0546849#ent", "<e2>", "in", "a", "double-blind", "randomised", "crossover", "trial", "in", "14", "patients", "who", "had", "previously", "been", "treated", "with", "diuretics", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [14, 15]}}
{"token": ["This", "suggests", "that", "the", "C3541401#ent", "<e1>", "act", "as", "C0016411#ent", "<e2>"], "h": {"id": "C3541401", "name": "C3541401#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016411", "name": "C0016411#ent", "pos": [8, 9]}}
{"token": ["Treatment", "of", "human", "myeloid", "cells", "with", "tumor", "necrosis", "factor", "TNF", ")", "rapidly", "activated", "NF-kappa", "B", "which", "consists", "of", "p50", "and", "C1335610#ent", "<e1>", "and", "this", "activation", "was", "inhibited", "by", "C4055175#ent", "<e2>", "."], "h": {"id": "C1335610", "name": "C1335610#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C4055175", "name": "C4055175#ent", "pos": [28, 29]}}
{"token": ["Measurements", "of", "IL-8", ",", "C0022575#ent", "<e1>", ",", "Bcl10", ",", "phospho-IkappaBalpha", ",", "nuclear", "NF-kappaB", "and", "phosphorylated", "C1333928#ent", "<e2>", "were", "performed", "by", "ELISA", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333928", "name": "C1333928#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "C1425164#ent", "<e1>", "co-localized", "to", "lamellipodia", "with", "C0812215#ent", "<e2>", "and", "to", "stress", "fibers", "MEK", "."], "h": {"id": "C1425164", "name": "C1425164#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [9, 10]}}
{"token": ["These", "results", "suggest", "that", "C3273594#ent", "<e1>", "enhances", "the", "reactivity", "of", "C0004135#ent", "<e2>", "with", "fXa", "primarily", "by", "lowering", "the", "K(E", ",", "ATH", ")", "for", "the", "formation", "of", "a", "Michaelis-type", "serpin-protease", "encounter", "complex", "."], "h": {"id": "C3273594", "name": "C3273594#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [10, 11]}}
{"token": ["12", "of", "16", "patients", "suffering", "from", "C0020550#ent", "<e1>", "were", "euthyrotic", "5", "weeks", "after", "the", "first", "C0001975#ent", "<e2>", "the", "thyrostatic", "dose", "had", "to", "be", "reduced", "in", "4", "patients", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [15, 16]}}
{"token": ["Regression", "of", "the", "C0037284#ent", "<e1>", "obtained", "with", "a", "protocol", "including", "daunoblastine", ",", "aracytin", "and", "C0039902#ent", "<e2>", ",", "but", "the", "patient", "relapsed", "and", "died", "a", "few", "months", "later", "without", "achieving", "another", "remission", "."], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [14, 15]}}
{"token": ["They", "are", "the", "members", "of", "the", "type-B", "family", "of", "response", "regulators", "specifically", ",", "ARR1", ",", "C1421543#ent", "<e1>", "and", "ARR10", ")", ",", "and", "a", "novel", "protein", "named", "C1420656#ent", "<e2>", "."], "h": {"id": "C1421543", "name": "C1421543#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420656", "name": "C1420656#ent", "pos": [26, 27]}}
{"token": ["Using", "a", "yeast", "two-hybrid", "library", "screen", "we", "have", "identified", "that", "the", "heart", "specific", "C1333547#ent", "<e1>", "four-and-a-half", "LIM", "protein", "2", ",", "interacted", "with", "human", "C0812382#ent", "<e2>", "hNP220", "."], "h": {"id": "C1333547", "name": "C1333547#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [23, 24]}}
{"token": ["Transfection", "with", "C1413500#ent", "<e1>", "but", "not", "other", "NCL", "C0017337#ent", "<e2>", "corrected", "growth", "apoptosis", "in", "CLN9-deficient", "cells", ",", "although", "the", "entire", "C1413500#ent", "<e1>", "sequence", "was", "normal", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413500", "name": "C1413500#ent", "pos": [2, 3]}}
{"token": ["Recently", ",", "the", "oral", "cavity", "identified", "as", "a", "possible", "H.", "pylori", "reservoir", ",", "particularly", "in", "the", "presence", "of", "C0017563#ent", "<e1>", "which", "is", "a", "cause", "of", "C0018520#ent", "<e2>", "."], "h": {"id": "C0017563", "name": "C0017563#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0018520", "name": "C0018520#ent", "pos": [25, 26]}}
{"token": ["Of", "note", ",", "a", "higher", "level", "of", "the", "HIV-1", "accessory", "protein", "C0079423#ent", "<e1>", "has", "been", "detected", "in", "the", "cerebrospinal", "fluid", "AIDS", "patients", "with", "C0042075#ent", "<e2>"], "h": {"id": "C0079423", "name": "C0079423#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [23, 24]}}
{"token": ["C0599295#ent", "<e1>", "fusion", "leading", "to", "the", "androgenic", "induction", "the", "ERG", "C0694890#ent", "<e2>", "a", "highly", "prevalent", "oncogenic", "alteration", "in", "prostate", "tumor", "cells"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [10, 11]}}
{"token": ["We", "identified", "this", "protein", "as", "C1704657#ent", "<e1>", "(", "FAK", ",", "focal", "adhesion", "kinase", "after", "analyzing", "C1417611#ent", "<e2>", "immunoprecipitates", "by", "anti-FAK", "immunoblotting"], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417611", "name": "C1417611#ent", "pos": [15, 16]}}
{"token": ["The", "C0023520#ent", "<e1>", "form", "a", "complex", "group", "C0019247#ent", "<e2>", "primarily", "affect", "myelin", ",", "the", "main", "constituent", "of", "the", "brain", "white", "matter"], "h": {"id": "C0023520", "name": "C0023520#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["Insulin", "treatment", "normalizes", "glycemia", "levels", ",", "partially", "counteracts", "C1419691#ent", "<e1>", "mRNA", "increase", "at", "both", "stages", "of", "C0011849#ent", "<e2>", "and", "delays", "MBP", "mRNA", "increase", "present", "only", "in", "chronic", "animals"], "h": {"id": "C1419691", "name": "C1419691#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [16, 17]}}
{"token": ["For", "children", "and", "adolescents", "with", "C0011849#ent", "<e1>", ",", "the", "risk", "of", "C0020615#ent", "<e2>", "may", "not", "only", "prevent", "optimal", "glycemic", "control", "but", "can", "also", "add", "significantly", "to", "the", "psychosocial", "burden", "the", "disease", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [11, 12]}}
{"token": ["The", "deacylating", "activity", "liver", "microsomes", "was", "inhibited", "by", "bis(4-nitrophenyl)phosphate", "and", "C0031493#ent", "<e1>", "inhibitors", "of", "C1413347#ent", "<e2>", "."], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413347", "name": "C1413347#ent", "pos": [14, 15]}}
{"token": ["The", "primary", "C2354171#ent", "<e1>", "activated", "by", "exposure", "of", "fibroblast", "cells", "proteasome", "inhibition", "is", "C1426334#ent", "<e2>", "(", "EIF2AK4", ")", ",", "which", "has", "a", "central", "role", "in", "the", "recognition", "of", "cytoplasmic", "stress", "signals", "."], "h": {"id": "C2354171", "name": "C2354171#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1426334", "name": "C1426334#ent", "pos": [13, 14]}}
{"token": ["The", "primary", "C2354171#ent", "<e1>", "activated", "by", "exposure", "of", "fibroblast", "cells", "proteasome", "inhibition", "is", "GCN2", "(", "C1426334#ent", "<e2>", ")", ",", "which", "has", "a", "central", "role", "in", "the", "recognition", "of", "cytoplasmic", "stress", "signals", "."], "h": {"id": "C2354171", "name": "C2354171#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1426334", "name": "C1426334#ent", "pos": [15, 16]}}
{"token": ["This", "increment", "is", "not", "observed", "in", "the", "cells", "expressing", "mammalian", "non-GCN2", "C2354171#ent", "<e1>", "place", "of", "C1426334#ent", "<e2>", "."], "h": {"id": "C2354171", "name": "C2354171#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1426334", "name": "C1426334#ent", "pos": [15, 16]}}
{"token": ["Our", "investigation", "of", "GLI", "protein", "and", "binding", "of", "C1706548#ent", "<e1>", "activators", "and", "repressor", "to", "C1335824#ent", "<e2>", "target", "genes", "provide", "insight", "into", "the", "molecular", "mechanisms", "which", "C1335824#ent", "<e2>", "and", "its", "C1706548#ent", "<e1>", "family", "of", "effectors", "control", "renal", "embryogenesis"], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706548", "name": "C1706548#ent", "pos": [8, 9]}}
{"token": ["A", "molecular", "defect", "the", "AChE", "in", "the", "ventricular", "CSF", "C0002395#ent", "<e1>", "patients", "is", "indicated", "by", "the", "finding", "that", "the", "C0027203#ent", "<e2>", "failed", "to", "show", "inhibition", "by", "high", "concentrations", "of", "substrate", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [19, 20]}}
{"token": ["C0132555#ent", "<e1>", "activity", "in", "the", "hypothalamus", "and", "C0032002#ent", "<e2>", "is", "increased", "by", "maneuvers", "known", "to", "stimulate", "vasopressin", "secretion", "including", "salt", "loading", "dehydration", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [7, 8]}}
{"token": ["The", "present", "study", "aimed", "at", "understanding", "the", "effect", "of", "dexamethasone", "(", "C0011816#ent", "<e1>", ")", "on", "change", "of", "C1705581#ent", "<e2>", "and", "mechanism", "of", "regulatory", "effect", "C1705581#ent", "<e2>", "on", "eosinophil", "(", "EOS", ")", "apoptosis", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705581", "name": "C1705581#ent", "pos": [17, 18]}}
{"token": ["We", "recently", "found", "that", "heterozygosity", "for", "the", "frequent", "(", "0.8", "%", "prevalence", "in", "Dutch", "population", "R1141X", "mutation", "in", "the", "C0033847#ent", "<e1>", "gene", "coding", "the", "ABCC6", "transporter", "is", "associated", "with", "fourfold", "risk", "of", "C1956346#ent", "<e2>"], "h": {"id": "C0033847", "name": "C0033847#ent", "pos": [19, 20]}, "relation": "has_manifestation", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [32, 33]}}
{"token": ["Although", "patients", "with", "C0033847#ent", "<e1>", "often", "have", "C1956346#ent", "<e2>", "little", "is", "known", "about", "the", "process", "and", "the", "mechanism", "of", "C1956346#ent", "<e2>", "C0033847#ent", "<e1>", "."], "h": {"id": "C0033847", "name": "C0033847#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [7, 8]}}
{"token": ["Hepatitis", "B", "virus", "HBV", ")", "transgenic", "mice", "rat", "hepatocyte", "nuclear", "factor", "3beta", "C2348502#ent", "<e1>", ")", "were", "generated", "by", "breeding", "HBV", "transgenic", "mice", "transgenic", "mice", "C0669365#ent", "<e2>", "overexpress", "the", "rat", "HNF3beta", "polypeptide", "in", "the", "liver", "."], "h": {"id": "C2348502", "name": "C2348502#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}}
{"token": ["At", "first", "we", "treated", "with", "antibiotics", "including", "C0013227#ent", "<e1>", "suspect", "of", "the", "C0025309#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025309", "name": "C0025309#ent", "pos": [12, 13]}}
{"token": ["We", "report", "here", "that", "C1333258#ent", "<e1>", ",", "a", "Vaccinia", "virus", "VH1-related", "dual-specific", "protein", "phosphatase", "inactivates", "the", "C0169101#ent", "<e2>", "Erk2", "and", "Jnk", ",", "is", "phosphorylated", "at", "Y138", "by", "ZAP-70", "."], "h": {"id": "C1333258", "name": "C1333258#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [16, 17]}}
{"token": ["We", "report", "here", "that", "VHR", ",", "a", "C1333258#ent", "<e1>", "inactivates", "the", "C0169101#ent", "<e2>", "Erk2", "and", "Jnk", ",", "is", "phosphorylated", "at", "Y138", "by", "ZAP-70", "."], "h": {"id": "C1333258", "name": "C1333258#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [11, 12]}}
{"token": ["The", "renal", "and", "hormonal", "responses", "C1417807#ent", "<e1>", "are", "not", "impaired", "in", "the", "C1704321#ent", "<e2>"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [12, 13]}}
{"token": ["We", "followed", "the", "renal", "and", "hormonal", "effects", "physiological", "intravenous", "infusions", "of", "C1417807#ent", "<e1>", "ANF", ")", "in", "6", "water-loaded", "patients", "with", "C1704321#ent", "<e2>", "7", "healthy", "subjects"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [20, 21]}}
{"token": ["Nonsteroidal", "antiandrogens", "antagonize", "this", "activation", ",", "but", "they", "switch", "to", "an", "C2987634#ent", "<e1>", "effect", "in", "the", "presence", "of", "C1335093#ent", "<e2>", "an", "IL-6-related", "cytokine", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335093", "name": "C1335093#ent", "pos": [18, 19]}}
{"token": ["We", "assessed", "the", "role", "of", "C2349086#ent", "<e1>", "genetic", "polymorphisms", "hydrocele", "development", "in", "a", "cohort", "of", "C0016085#ent", "<e2>", "patients", "from", "Ghana", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016085", "name": "C0016085#ent", "pos": [15, 16]}}
{"token": ["These", "C0004099#ent", "<e1>", "cellular", "responses", "be", "simulated", "in", "vitro", "treating", "blood", "with", "C3537171#ent", "<e2>", "15", "mM", ")", ",", "but", "not", "by", "low", "pH", "(", "7.1", ")", "or", "L-lactate", "alone", "."], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3537171", "name": "C3537171#ent", "pos": [12, 13]}}
{"token": ["Previously", "we", "found", "that", "interleukin", "2", "C0879590#ent", "<e1>", ")", "induces", "tyrosine", "phosphorylation", "activation", "of", "the", "C1414204#ent", "<e2>", "encoded", "by", "the", "raf-1", "protooncogene", "a", "T-cell", "line", "CTLL-2", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414204", "name": "C1414204#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "review", "the", "mechanism", "of", "C1421354#ent", "<e1>", "degradation", "with", "particular", "emphasis", "on", "C1417921#ent", "<e2>", "(", "antizyme", "inhibitor", ",", "an", "C1421354#ent", "<e1>", "homologous", "protein", "appears", "as", "a", "central", "regulator", "C1421354#ent", "<e1>", "stability", ",", "cellular", "polyamine", "homoeostasis", "and", "cellular", "proliferation"], "h": {"id": "C1421354", "name": "C1421354#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417921", "name": "C1417921#ent", "pos": [13, 14]}}
{"token": ["The", "recent", "introduction", "of", "C0017887#ent", "<e1>", "GTN", ")", "has", "greatly", "changed", "the", "management", "of", "C0016167#ent", "<e2>"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0016167", "name": "C0016167#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "neuroprotective", "properties", "C0751039#ent", "<e1>", "and", "MP", "in", "a", "C0917798#ent", "<e2>", "model", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [16, 17]}}
{"token": ["We", "present", "a", "case", "of", "a", "37-year-old", "man", "with", "C0039591#ent", "<e1>", "was", "found", "to", "have", "a", "testicular", "mass", "diagnosed", "as", "granulocytic", "sarcoma", "C0017097#ent", "<e2>", ")", "."], "h": {"id": "C0039591", "name": "C0039591#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017097", "name": "C0017097#ent", "pos": [22, 23]}}
{"token": ["Evidence", "is", "presented", "that", "NGF", "regulates", "C1418953#ent", "<e1>", "phosphorylation", "by", "a", "mechanism", "independent", "of", "C0010531#ent", "<e2>", "C", "and", "of", "depolarization", "."], "h": {"id": "C1418953", "name": "C1418953#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [14, 15]}}
{"token": ["However", ",", "C0008294#ent", "<e1>", "and", "lisinopril", "were", "more", "effective", "at", "preventing", "C0018801#ent", "<e2>", "whereas", "amlodipine", "and", "C0008294#ent", "<e1>", "were", "more", "effective", "than", "lisinopril", "at", "preventing", "stroke", "."], "h": {"id": "C0008294", "name": "C0008294#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}}
{"token": ["Downstream", "of", "the", "pyruvate", "carboxylase", "gene-containing", "fragment", ",", "a", "gene", "cluster", "for", "C0079941#ent", "<e1>", "extensive", "homology", "to", "C1413745#ent", "<e2>", "aconitase", ",", "and", "a", "truncated", "isocitrate", "dehydrogenase", "identified", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413745", "name": "C1413745#ent", "pos": [17, 18]}}
{"token": ["We", "showed", "that", "the", "fourth", "C0079941#ent", "<e1>", "encoded", "a", "third", "isozyme", "of", "C1413745#ent", "<e2>", "B.", "subtilis", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413745", "name": "C1413745#ent", "pos": [12, 13]}}
{"token": ["APA", "showed", "increased", "expression", "of", "the", "mRNA", "for", "C1413856#ent", "<e1>", "and", "decreased", "expression", "of", "the", "mRNA", "for", "C1706114#ent", "<e2>", "."], "h": {"id": "C1413856", "name": "C1413856#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706114", "name": "C1706114#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "studies", "of", "cells", "deficient", "in", "XPC", "or", "in", "the", "genes", "implicated", "in", "C0009207#ent", "<e1>", "CSA", "and", "C1707866#ent", "<e2>", ")", "indicated", "that", "the", "drug", "sensitivity", "specifically", "dependent", "on", "the", "transcription-coupled", "pathway", "NER", "."], "h": {"id": "C0009207", "name": "C0009207#ent", "pos": [14, 15]}, "relation": "disease_has_associated_gene", "t": {"id": "C1707866", "name": "C1707866#ent", "pos": [18, 19]}}
{"token": ["The", "C0027803#ent", "<e1>", "content", "of", "C0155862#ent", "<e2>", "found", "to", "be", "dependent", "on", "the", "media", "employed", "for", "growth", ";", "the", "highest", "enzyme", "activity", "milligram", "of", "bacterial", "protein", "obtained", "with", "Todd-Hewitt", "broth", "."], "h": {"id": "C0027803", "name": "C0027803#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0155862", "name": "C0155862#ent", "pos": [5, 6]}}
{"token": ["Human", "glandular", "kallikrein", "2", "hK2", ")", "and", "prostate-specific", "antigen", "C1418948#ent", "<e1>", ")", "are", "members", "of", "a", "C0017363#ent", "<e2>", "serine", "proteases", "share", "approximately", "80", "%", "sequence", "homology", "."], "h": {"id": "C1418948", "name": "C1418948#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [16, 17]}}
{"token": ["We", "describe", "a", "44-year-old", "woman", "with", "progressive", "headache", ",", "ataxia", ",", "and", "C0036572#ent", "<e1>", "in", "association", "with", "multifocal", "cerebral", "C1858991#ent", "<e2>", "intracranial", "calcifications", "and", "cysts", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C1858991", "name": "C1858991#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "C3539637#ent", "<e1>", "might", "be", "utilized", "as", "effective", "C0596112#ent", "<e2>", "and", "are", "currently", "under", "clinical", "trials"], "h": {"id": "C3539637", "name": "C3539637#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0596112", "name": "C0596112#ent", "pos": [9, 10]}}
{"token": ["The", "PAX2", "gene", "mutated", "in", "patients", "with", "ocular", "colobomas", "C0042580#ent", "<e1>", "VUR", ")", ",", "and", "kidney", "anomalies", "C1852759#ent", "<e2>", "OMIM", "120330", ")", "."], "h": {"id": "C0042580", "name": "C0042580#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C1852759", "name": "C1852759#ent", "pos": [17, 18]}}
{"token": ["C1415975#ent", "<e1>", "specific", "to", "C0072074#ent", "<e2>", "binds", "human", "profilin", "I.", "This", "cross-reactivity", "between", "airborne", "and", "endogenous", "proteins", "may", "help", "to", "sustain", "allergy", "symptoms", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072074", "name": "C0072074#ent", "pos": [4, 5]}}
{"token": ["Both", "tooth", "development", "enamel", "knots", "regulated", "by", "a", "cascade", "of", "gene", "activity", "C1524098#ent", "<e1>", ",", "Shh", ",", "BMP4", ",", "Lef1", "and", "C1420626#ent", "<e2>", "are", "the", "prime", "movers", "the", "processes", "."], "h": {"id": "C1524098", "name": "C1524098#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [21, 22]}}
{"token": ["To", "improve", "diagnostic", "and", "therapeutic", "efficiency", "for", "all", "C0012634#ent", "<e1>", "the", "Department", "of", "Health", "Social", "Security", "prepare", "a", "procedure", "manual", "for", "the", "C0796085#ent", "<e2>", "that", "gives", "guidance", "for", "doctors", "and", "other", "medical", "staff"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0796085", "name": "C0796085#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "electrophoretic", "mobility", "shift", "assays", "that", "C1705457#ent", "<e1>", "inhibited", "the", "activations", "of", "C2986464#ent", "<e2>", "and", "AP-1", "induced", "by", "PMA", "in", "BET-1A", "cells", "."], "h": {"id": "C1705457", "name": "C1705457#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "each", "member", "of", "the", "C2985150#ent", "<e1>", "series", "has", "structural", "features", "typical", "of", "members", "of", "the", "C0072402#ent", "<e2>", "protein", "kinases"], "h": {"id": "C2985150", "name": "C2985150#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "C0074722#ent", "<e1>", "concentration", "in", "C1141624#ent", "<e2>", "on", "end", "product", "distribution", ",", "growth", "rate", "and", "metabolic", "rates", "also", "examined", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1141624", "name": "C1141624#ent", "pos": [7, 8]}}
{"token": ["The", "activation", "of", "telomerase", "by", "C0035018#ent", "<e1>", "in", "lymphocytes", "was", "also", "accompanied", "by", "inactivation", "of", "C0003015#ent", "<e2>"], "h": {"id": "C0035018", "name": "C0035018#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [15, 16]}}
{"token": ["The", "alfalfa", "HSPs", "share", "a", "homologous", "stretch", "of", "C3539947#ent", "<e1>", "the", "carboxy", "terminal", "region", "with", "C1428937#ent", "<e2>", ",", "23", ",", "26", "from", "Drosophila", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1428937", "name": "C1428937#ent", "pos": [15, 16]}}
{"token": ["The", "most", "common", "mononuclear", "C3887558#ent", "<e1>", "the", "familial", "erythrophagocytic", "lymphohistiocytosis", "infection-associated", "or", "C0019068#ent", "<e2>"], "h": {"id": "C3887558", "name": "C3887558#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019068", "name": "C0019068#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "C1705010#ent", "<e1>", "are", "not", "associated", "with", "vascular", "perfusion", "changes", "in", "C0030193#ent", "<e2>", "opposed", "to", "migraine", "headaches"], "h": {"id": "C1705010", "name": "C1705010#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [13, 14]}}
{"token": ["Our", "study", "showed", "beneficial", "effects", "of", "ETK", "when", "used", "in", "combination", "with", "other", "C0010406#ent", "<e1>", "on", "the", "viability", "of", "thawed", "C0669372#ent", "<e2>", "."], "h": {"id": "C0010406", "name": "C0010406#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [20, 21]}}
{"token": ["Cyclooxygenase", "inhibitors", "C0004057#ent", "<e1>", "indomethacin", ",", "tolazoline", ")", "do", "not", "block", "maturation", "prostaglandins", "E2", "C1414052#ent", "<e2>", ",", "F2", "alpha", "I2", ",", "and", "thromboxane", "B2", "not", "induce", "meiosis", "reinitiation", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", "C1442753#ent", "<e1>", "cross-linking", "persistently", "activates", "Rap1", "C1333729#ent", "<e2>", "in", "a", "LFA-1-dependent", "manner", "and", "induces", "LFA-1/ICAM-1-mediated", "cell", "adhesion", "in", "lymphocytes", "."], "h": {"id": "C1442753", "name": "C1442753#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333729", "name": "C1333729#ent", "pos": [9, 10]}}
{"token": ["This", "ointment", "is", "recommended", "for", "active", "therapy", "patients", "with", "local", "C3890176#ent", "<e1>", "plaques", "with", "a", "stable", "course", "of", "the", "condition", ",", "C0023380#ent", "<e2>", "to", "routine", "antipsoriatic", "therapy", "."], "h": {"id": "C3890176", "name": "C3890176#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [21, 22]}}
{"token": ["Late", "reactions", "C0016034#ent", "<e1>", "telangiectases", "and", "C0425791#ent", "<e2>", "reduced", "if", "more", "treatment", "fractions", "are", "given", "."], "h": {"id": "C0016034", "name": "C0016034#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0425791", "name": "C0425791#ent", "pos": [6, 7]}}
{"token": ["Non-cirrhotic", "portal", "hypertension", "(", "C4310735#ent", "<e1>", ")", "is", "a", "common", "cause", "of", "C0020541#ent", "<e2>", "developing", "countries", "especially", "Asia", "."], "h": {"id": "C4310735", "name": "C4310735#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0020541", "name": "C0020541#ent", "pos": [12, 13]}}
{"token": ["The", "majority", "of", "the", "diseases", "included", "in", "the", "category", "of", "C4310735#ent", "<e1>", "are", "well", "characterized", "disease", "entities", "C0020541#ent", "<e2>", "PHT", ")", "is", "a", "late", "manifestation", "hence", ",", "these", "are", "not", "discussed", "."], "h": {"id": "C4310735", "name": "C4310735#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0020541", "name": "C0020541#ent", "pos": [17, 18]}}
{"token": ["C1701467#ent", "<e1>", "for", "6-hydroxypurine", "monophosphate", "derivatives", "(", "C1417862#ent", "<e2>", ")", ",", "belongs", "to", "a", "class", "of", "phosphohydrolases", "that", "act", "through", "the", "formation", "of", "an", "enzyme-phosphate", "intermediate", "."], "h": {"id": "C1701467", "name": "C1701467#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417862", "name": "C1417862#ent", "pos": [7, 8]}}
{"token": ["These", "include", "alkylating", "agents", "antimetabolites", ",", "nucleoside", "analogs", "topoisomerase", "I", "inhibitors", "topisomerase", "II", "inhibitors", "C0002062#ent", "<e1>", "taxanes", ",", "and", "biologics", "such", "as", "signaling", "and", "growth", "factor", "C0035064#ent", "<e2>", "."], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [26, 27]}}
{"token": ["Pulmonary", "DCs", "from", "C5aR-targeted", "mice", "produced", "large", "amounts", "of", "CC", "chemokine", "17", "(", "CCL17", ")", "and", "C1332685#ent", "<e1>", "ex", "vivo", "suggesting", "a", "negative", "impact", "of", "C1824180#ent", "<e2>", "signaling", "on", "pulmonary", "homing", "Th2", "cells"], "h": {"id": "C1332685", "name": "C1332685#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1824180", "name": "C1824180#ent", "pos": [25, 26]}}
{"token": ["In", "this", "context", ",", "we", "have", "found", "that", "neutral", "endopeptidase-24.11", ",", "a", "C1334706#ent", "<e1>", "controlling", "the", "action", "of", "neuroendocrine", "peptides", "also", "of", "immunocyte", "chemotaxis", "is", "C3889446#ent", "<e2>", "during", "aging", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [25, 26]}}
{"token": ["Ets", "factors", "regulate", "matrix", "turnover", "by", "activating", "transcription", "of", "several", "C1334706#ent", "<e1>", "(", "MMPs", ")", "and", "are", "frequently", "C3889446#ent", "<e2>", "in", "aggressive", "tumors", "arthritis", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [18, 19]}}
{"token": ["The", "decrease", "in", "synthesis", "observed", "after", "exposure", "to", "actinomycin", "D", "not", "reflected", "by", "any", "significant", "decrease", "in", "the", "activities", "of", "several", "C0085249#ent", "<e1>", "involved", "in", "chondroitin", "sulphate", "synthesis", "galactosyltransferase-I", ",", "C0130707#ent", "<e2>", "glucuronosyltransferase-II", ")", "."], "h": {"id": "C0085249", "name": "C0085249#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0130707", "name": "C0130707#ent", "pos": [30, 31]}}
{"token": ["Suppression", "of", "C1413347#ent", "<e1>", "cytotoxicity", "in", "later", "stages", "of", "HIV-1", "infection", "C0001857#ent", "<e2>", "AIDS", ")", "could", "partly", "be", "reverted", "by", "treatment", "with", "the", "cyclooxygenase", "blocker", "indomethacin", "."], "h": {"id": "C1413347", "name": "C1413347#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001857", "name": "C0001857#ent", "pos": [11, 12]}}
{"token": ["It", "is", "characterized", "by", "a", "nonprogressive", "bilateral", "facial", "paralysis", "the", "inability", "of", "the", "C0235267#ent", "<e1>", "to", "abduct", "beyond", "the", "midline", ",", "orofacial", "anomalies", "limb", "C0268487#ent", "<e2>", ",", "and", "an", "absence", "or", "hypoplasia", "of", "the", "pectoral", "muscles"], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [24, 25]}}
{"token": ["Binding", "is", "increased", "in", "the", "presence", "of", "C1333909#ent", "<e1>", "+", "and", "is", "unaffected", "by", "AMPA", "or", "C0205812#ent", "<e2>", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [16, 17]}}
{"token": ["In", "C1333909#ent", "<e1>", "+", "-containing", "medium", ",", "neuronal", "depolarization", "induced", "either", "by", "C0205812#ent", "<e2>", "or", "by", "high", "K+", "potentiated", "NMDA", "toxicity", ",", "apparently", "by", "reducing", "the", "channel", "block", "C1333909#ent", "<e1>", "+", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [12, 13]}}
{"token": ["We", "examined", "the", "effect", "of", "brain", "tissue", "hypoxia", "on", "the", "NMDA", "receptor-ion", "channel", "complex", "including", "the", "glutamate", ",", "C1333909#ent", "<e1>", "+", ",", "spermine", ",", "CPP", ",", "and", "the", "non-NMDA", "receptor", "C0205812#ent", "<e2>", "sites", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [30, 31]}}
{"token": ["C0025853#ent", "<e1>", "been", "approved", "for", "use", "in", "the", "acute", "and", "chronic", "management", "C0152020#ent", "<e2>"], "h": {"id": "C0025853", "name": "C0025853#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0152020", "name": "C0152020#ent", "pos": [12, 13]}}
{"token": ["A", "59-year-old", "woman", "has", "been", "treated", "for", "5", "months", "with", "C0030817#ent", "<e1>", "for", "a", "rheumatoid", "arthritis", "developed", "a", "C0022972#ent", "<e2>", "ptosis", ",", "diplopia", ",", "dysphagia", "and", "asthenia", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022972", "name": "C0022972#ent", "pos": [18, 19]}}
{"token": ["In", "HCV(+", ")", "patients", ",", "CD4(+", ")", "T", "cells", "were", "inversely", "correlated", "with", "C0001899#ent", "<e1>", "ALT", ")", "levels", "and", "with", "C0041948#ent", "<e2>", "."], "h": {"id": "C0001899", "name": "C0001899#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041948", "name": "C0041948#ent", "pos": [20, 21]}}
{"token": ["This", "implies", "that", "intracellular", "targets", "of", "albumin", ",", "C0001477#ent", "<e1>", "HCO(3)(-", ")", "may", "be", "constitutively", "active", "in", "C0268151#ent", "<e2>", "I-null", "sperm", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268151", "name": "C0268151#ent", "pos": [17, 18]}}
{"token": ["Using", "specific", "small", "molecule", "inhibitors", "find", "that", "a", "combination", "of", "the", "Src", "family", "kinase", "phosphatidylinositol", "3-kinase/Akt", ",", "phospholipase", "C", "and", "C3849574#ent", "<e1>", "pathways", "mediates", "macrophage", "proliferation", "response", "to", "C1524095#ent", "<e2>", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1524095", "name": "C1524095#ent", "pos": [28, 29]}}
{"token": ["Here", "we", "report", "that", "stimulation", "with", "IFN-gamma", "prolongs", "the", "pattern", "of", "C3849574#ent", "<e1>", "activity", "induced", "by", "C1524095#ent", "<e2>", "in", "macrophages", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1524095", "name": "C1524095#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "this", "work", "is", "the", "molecular", "description", "a", "4", "new", "cases", "of", "the", "hemoglobin", "Fannin-Lubbock", "II", "which", "presents", "the", "substitution", "of", "2", "C3539947#ent", "<e1>", "the", "same", "C0544483#ent", "<e2>"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0544483", "name": "C0544483#ent", "pos": [28, 29]}}
{"token": ["We", "detected", "a", "T/C", "nucleotide", "variation", "at", "nucleotide", "32770", "in", "the", "poly-A", "region", "of", "the", "C1705338#ent", "<e1>", "the", "mother", "of", "a", "C0008533#ent", "<e2>", "child", "."], "h": {"id": "C1705338", "name": "C1705338#ent", "pos": [15, 16]}, "relation": "gene_associated_with_disease", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [21, 22]}}
{"token": ["The", "human", "mAbs", "could", "modulate", "the", "epitope", "repertoire", "when", "TPO", "was", "added", "exogenously", "and", "when", "expressed", "C0669365#ent", "<e1>", "on", "the", "surface", "of", "C1456795#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [22, 23]}}
{"token": ["In", "all", "cases", ",", "MRA", "VR", "delineated", "C0751003#ent", "<e1>", "more", "clearly", "compared", "to", "C1416706#ent", "<e2>", "."], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416706", "name": "C1416706#ent", "pos": [13, 14]}}
{"token": ["Anti", "lipid", "A-antibodies", "to", "be", "highly", "C1413309#ent", "<e1>", "with", "purified", "C0175697#ent", "<e2>", "and", "lipid", "A", "several", "gram-negative", "organisms"], "h": {"id": "C1413309", "name": "C1413309#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [10, 11]}}
{"token": ["Based", "on", "the", "measured", "Ca2", "+", "-dependence", ",", "we", "propose", "that", "Ca2", "+", "-binding", "to", "the", "C-terminal", "pair", "high", "affinity", "sites", "in", "C1861821#ent", "<e1>", "inhibits", "the", "C4284731#ent", "<e2>", "actin-activated", "ATPase", "activity", "."], "h": {"id": "C1861821", "name": "C1861821#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C4284731", "name": "C4284731#ent", "pos": [26, 27]}}
{"token": ["Examples", "include", "evaluation", "for", "shoulder", "and", "ankle", "tendon", "abnormalities", "C0149778#ent", "<e1>", "joint", "effusion", "soft", "tissue", "foreign", "bodies", "soft", "tissue", "masses", "such", "as", "Baker's", "cyst", "wrist", "ganglion", "cyst", "C0007286#ent", "<e2>", "developmental", "dysplasia", "the", "hip", ";", "and", "other", "indications", "where", "MR", "imaging", "contraindicated", "."], "h": {"id": "C0149778", "name": "C0149778#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [27, 28]}}
{"token": ["The", "distal", "portion", "five", "class", "III", "genes", "two", "C1705747#ent", "<e1>", "the", "proximal", "portion", "contained", "five", "C0017337#ent", "<e2>", "or", "pseudogenes", "belonging", "to", "the", "class", "I", "region"], "h": {"id": "C1705747", "name": "C1705747#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["The", "quantitative", "MRI", "data", "revealed", "significant", "cerebellar", "and", "pontine", "atrophy", "the", "patients", "with", "C2931903#ent", "<e1>", "OPCA", ")", ",", "and", "C0007761#ent", "<e2>", "the", "patients", "with", "late", "cerebellar", "cortical", "atrophy", "LCCA", ")", "."], "h": {"id": "C2931903", "name": "C2931903#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007761", "name": "C0007761#ent", "pos": [19, 20]}}
{"token": ["Laboratory", "exams", "positive", "antinuclear-antibody", ",", "LE-cell", "phenomenon", ",", "C0853888#ent", "<e1>", "and", "lupus", "C0003280#ent", "<e2>", "."], "h": {"id": "C0853888", "name": "C0853888#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "the", "effect", "of", "C0011777#ent", "<e1>", "on", "gentamicin", "prophylaxis", "of", "pseudophakic", "C1531510#ent", "<e2>", "a", "rabbit", "model", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1531510", "name": "C1531510#ent", "pos": [12, 13]}}
{"token": ["Diclofenac", "sodium", "better", "results", "by", "improving", "the", "signs", "and", "symptoms", "of", "C0029408#ent", "<e1>", "in", "both", "high", "and", "low", "doses", "compared", "to", "C0016377#ent", "<e2>", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0016377", "name": "C0016377#ent", "pos": [21, 22]}}
{"token": ["The", "diets", "of", "Western", "countries", "contained", "increasingly", "larger", "amounts", "of", "linoleic", "acid", "C1420423#ent", "<e1>", ")", ",", "which", "has", "been", "promoted", "for", "its", "C0003277#ent", "<e2>"], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003277", "name": "C0003277#ent", "pos": [22, 23]}}
{"token": ["Oncostatin", "M", "OSM", ")", "in", "combination", "with", "tumour", "necrosis", "factor", "alpha", "TNF", "alpha", "promotes", "marked", "C0009325#ent", "<e1>", "breakdown", "from", "C0106940#ent", "<e2>", "explant", "culture", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0106940", "name": "C0106940#ent", "pos": [19, 20]}}
{"token": ["Propranolol", "completely", "blocked", ",", "but", "C0733398#ent", "<e1>", "partly", "reversed", ",", "the", "suppressive", "effect", "of", "C0030557#ent", "<e2>", "on", "the", "Con", "A-induced", "lymphocyte", "proliferation"], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030557", "name": "C0030557#ent", "pos": [14, 15]}}
{"token": ["The", "higher", "rate", "of", "HII", "on", "DWI-MRI", "in", "IT", "than", "in", "C0004135#ent", "<e1>", "is", "likely", "multifactorial", ",", "involving", "respiratory", "insufficiency", "C0036572#ent", "<e2>", ",", "and", "intracranial", "mass-occupying", "lesions", "requiring", "neurosurgical", "intervention"], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [20, 21]}}
{"token": ["The", "trial", "evaluated", "the", "effectiveness", "of", "the", "investigational", "antihistaminic", "and", "antiallergic", "compound", "C0771004#ent", "<e1>", "Eye", "Drops", "AZE", ")", "in", "the", "treatment", "of", "C0009766#ent", "<e2>", "an", "allergen", "challenge", "model"], "h": {"id": "C0771004", "name": "C0771004#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "show", "that", "SPP", "signals", "through", "the", "EDG-1", "receptor", "the", "heterotrimeric", "G", "protein", "G(i", ",", "leading", "to", "activation", "of", "the", "C1420479#ent", "<e1>", "phosphorylation", "of", "the", "Akt", "substrate", ",", "endothelial", "nitric-oxide", "synthase", "C1328053#ent", "<e2>", ")", "."], "h": {"id": "C1420479", "name": "C1420479#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [32, 33]}}
{"token": ["p12(CDK2-AP1", ")", "(", "C1422411#ent", "<e1>", ")", "is", "a", "C1332732#ent", "<e2>", "negatively", "regulates", "its", "kinase", "activity"], "h": {"id": "C1422411", "name": "C1422411#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332732", "name": "C1332732#ent", "pos": [8, 9]}}
{"token": ["Porcine", "neutral", "glycosidase", "moderately", "inhibited", "by", "D-galactonic", "acid", "and", "strongly", "inhibited", "by", "D-gluconic", "acid", "delta-lactone", "however", ",", "C0005220#ent", "<e1>", "not", "inhibited", "by", "the", "C0061387#ent", "<e2>", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0061387", "name": "C0061387#ent", "pos": [23, 24]}}
{"token": ["Instead", ",", "C1332020#ent", "<e1>", "is", "processed", "by", "C0919550#ent", "<e2>", "at", "the", "cell", "surface"], "h": {"id": "C1332020", "name": "C1332020#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [7, 8]}}
{"token": ["Seborrheic", "dermatitis", "be", "seen", "in", "conjunction", "with", "other", "C0037274#ent", "<e1>", "such", "as", "C0035854#ent", "<e2>", ",", "blepharitis", "or", "ocular", "rosacea", "and", "acne", "vulgaris"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0035854", "name": "C0035854#ent", "pos": [12, 13]}}
{"token": ["Specific", "noncovalent", "C3274824#ent", "<e1>", "dimeric", "complexes", "confirmed", "by", "chemically", "cross-linking", "recombinant", "Ala43", "C2984536#ent", "<e2>", "or", "C2984536#ent", "<e2>", "with", "bis", "(", "sulfosuccinimidyl", ")", "suberate", ",", "followed", "by", "SDS/PAGE", "."], "h": {"id": "C3274824", "name": "C3274824#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2984536", "name": "C2984536#ent", "pos": [12, 13]}}
{"token": ["The", "variant", "C1706112#ent", "<e1>", "of", "the", "Gly482Ser", "polymorphism", "in", "peroxisome", "proliferator-activated", "receptor-gamma", "co-activator-1alpha", "PPARGC1A", "or", "C1418779#ent", "<e2>", ")", ",", "a", "critical", "determinant", "of", "skeletal", "muscle", "metabolism", ",", "has", "been", "associated", "with", "obesity", "and", "type", "2", "diabetes"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [15, 16]}}
{"token": ["The", "variant", "C1706112#ent", "<e1>", "of", "the", "Gly482Ser", "polymorphism", "in", "peroxisome", "proliferator-activated", "receptor-gamma", "co-activator-1alpha", "C1418779#ent", "<e2>", "or", "PGC1alpha", ")", ",", "a", "critical", "determinant", "of", "skeletal", "muscle", "metabolism", ",", "has", "been", "associated", "with", "obesity", "and", "type", "2", "diabetes"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [13, 14]}}
{"token": ["C1510848#ent", "<e1>", "the", "C1420423#ent", "<e2>", "solution", "did", "not", "significantly", "improve", "the", "pain", "scores", "C1420423#ent", "<e2>", "infiltration", "in", "the", "presence", "of", "EMLA", "."], "h": {"id": "C1510848", "name": "C1510848#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [3, 4]}}
{"token": ["We", "discuss", "the", "indication", "of", "plasmapheresis", "in", "Guillain-Barr\u00e9", "syndrome", "multiple", "sclerosis", "C0393819#ent", "<e1>", "HTLV-1", "myelopathy", "HIV", "peripheral", "neuropathy", "myelopathy", ",", "paraproteinemias", ",", "C0085655#ent", "<e2>", ",", "and", "dermatomyositis", "."], "h": {"id": "C0393819", "name": "C0393819#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085655", "name": "C0085655#ent", "pos": [22, 23]}}
{"token": ["C0394016#ent", "<e1>", "cases", "of", "C0014547#ent", "<e2>", "may", "even", "occur", "more", "than", "five", "years", "after", "injury", "."], "h": {"id": "C0394016", "name": "C0394016#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [4, 5]}}
{"token": ["Although", "several", "AEDs", "have", "been", "shown", "to", "be", "anti-epileptogenic", "in", "animal", "models", "no", "data", "prove", "the", "efficacy", "of", "any", "AED", "in", "preventing", "the", "development", "of", "C0394016#ent", "<e1>", "or", "postoperative", "C0014547#ent", "<e2>", "."], "h": {"id": "C0394016", "name": "C0394016#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [29, 30]}}
{"token": ["Low", "C0813171#ent", "<e1>", "and", "Hyl", "values", "were", "found", "in", "C0003872#ent", "<e2>", "lesions", "."], "h": {"id": "C0813171", "name": "C0813171#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [9, 10]}}
{"token": ["There", "were", "no", "age-related", "differences", "the", "content", "of", "C0813171#ent", "<e1>", "and", "Hyl", "between", "samples", "of", "uninvolved", "skin", "of", "C0003872#ent", "<e2>", "."], "h": {"id": "C0813171", "name": "C0813171#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [18, 19]}}
{"token": ["This", "hypothesis", "was", "tested", "experimentally", "by", "measuring", "the", "effect", "of", "activation", "or", "blockade", "of", "K+", "channels", "[Ca2+]i", "using", "quin-2", "and", "C0063477#ent", "<e1>", "and", "by", "determining", "the", "effect", "of", "C2985407#ent", "<e2>", "lectin-induced", "proliferation", "."], "h": {"id": "C0063477", "name": "C0063477#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2985407", "name": "C2985407#ent", "pos": [28, 29]}}
{"token": ["Measurements", "of", "oxygen", "uptake", "isolated", "soybean", "root", "nodule", "cells", "in", "the", "presence", "of", "cyanide", "and", "C0073980#ent", "<e1>", "that", "alternative", "oxidase", "activity", "confined", "to", "the", "uninfected", "C0001614#ent", "<e2>", "the", "nodule", "."], "h": {"id": "C0073980", "name": "C0073980#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [25, 26]}}
{"token": ["Erysipelas", "is", "a", "C0004623#ent", "<e1>", "the", "dermis", "and", "hypodermis", ",", "mostly", "of", "C0036689#ent", "<e2>"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0036689", "name": "C0036689#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "rational", "antimicrobial", "treatment", "of", "common", "paediatric", "C0004623#ent", "<e1>", "such", "as", "C0036689#ent", "<e2>", "acute", "otitis", "media", "acute", "sinusitis", "bacterial", "pneumonia", "pertussis", ",", "Lyme", "borreliosis", "early", "stage", "and", "lower", "urinary", "tract", "infection", "reviewed", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0036689", "name": "C0036689#ent", "pos": [12, 13]}}
{"token": ["The", "data", "suggest", "that", "the", "increased", "levels", "of", "colligin", "in", "C1418192#ent", "<e1>", "may", "contribute", "to", "the", "deposition", "of", "C0009325#ent", "<e2>", "and", "consequent", "increased", "fibrosis", "in", "the", "oral", "submucosa", "C1418192#ent", "<e1>", "lesions", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1418192", "name": "C1418192#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "the", "mechanism", "of", "C0009325#ent", "<e1>", "accumulation", "in", "oral", "submucous", "fibrosis", "C1418192#ent", "<e2>", ")", "tissues", ",", "we", "examined", "the", "biosynthesis", "of", "C0009325#ent", "<e1>", "in", "fibroblast", "cultures", "from", "C1418192#ent", "<e2>", "lesions", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418192", "name": "C1418192#ent", "pos": [12, 13]}}
{"token": ["All", "of", "them", "had", "C0011860#ent", "<e1>", "were", "on", "sulfonylurea", "drugs", "tolbutamide", "or", "C0017642#ent", "<e2>", ")", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0017642", "name": "C0017642#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "combined", "insulin-glibenclamide", "therapy", "on", "glucose", "control", "evaluated", "in", "a", "double-blind", "placebo", "controlled", "study", "20", "patients", "with", "non-insulin-dependent", "diabetes", "mellitus", "C0011860#ent", "<e1>", ")", "and", "second", "failure", "to", "oral", "antidiabetic", "therapy", "glibenclamide", "or", "C0017642#ent", "<e2>", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [22, 23]}, "relation": "may_be_treated_by", "t": {"id": "C0017642", "name": "C0017642#ent", "pos": [34, 35]}}
{"token": ["In", "contrast", "to", "C1883559#ent", "<e1>", "rs1", "is", "expressed", "in", "early", "leaf", "primordia", "of", "C1419765#ent", "<e2>", "mutant", "plants", ",", "suggesting", "that", "ectopic", "expression", "causes", "the", "mutant", "phenotype", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419765", "name": "C1419765#ent", "pos": [13, 14]}}
{"token": ["Unlike", "previous", "studies", "using", "C0009014#ent", "<e1>", ",", "we", "find", "no", "differences", "in", "Bmax", "or", "C1705240#ent", "<e2>", "of", "the", "high", "affinity", "alpha", "2-adrenoceptor", "binding", "sites", "between", "the", "2", "groups", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [14, 15]}}
{"token": ["Confocal", "microscopy", "that", "monocytes", "from", "VL", "patients", "who", "had", "been", "treated", ",", "with", "C0030895#ent", "<e1>", "SAG", ")", ",", "did", "display", "C1334083#ent", "<e2>", "up-regulation", "."], "h": {"id": "C0030895", "name": "C0030895#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334083", "name": "C1334083#ent", "pos": [20, 21]}}
{"token": ["The", "current", "hypertension", "(", "C0020538#ent", "<e1>", ")", "guidelines", "recommend", "the", "assessment", "of", "other", "C0007222#ent", "<e2>", "CVD", ")", "risk", "factors", "individuals", "with", "C0020538#ent", "<e1>", "for", "further", "management", "."], "h": {"id": "C0007222", "name": "C0007222#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [4, 5]}}
{"token": ["C0070203#ent", "<e1>", "are", "negatively", "charged", "polysaccharides", "employed", "as", "stabilizers", "in", "C3537171#ent", "<e2>", "dispersions", ",", "where", "caseins", "aggregate", "because", "of", "the", "low", "pH", "and", "serum", "separation", "to", "be", "prevented", "."], "h": {"id": "C0070203", "name": "C0070203#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537171", "name": "C3537171#ent", "pos": [10, 11]}}
{"token": ["These", "were", "cases", "where", "the", "C0238111#ent", "<e1>", "had", "followed", "another", "type", "of", "C0014544#ent", "<e2>", ",", "mostly", "of", "the", "idiopathic", "generalized", "type", "."], "h": {"id": "C0238111", "name": "C0238111#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [12, 13]}}
{"token": ["Patient", "1", "C0238111#ent", "<e1>", "auditory-induced", "generalized", "atonic", "or", "tonic", "seizures", "C0014544#ent", "<e2>", ",", "which", "decreased", "by", "60", "%", "after", "callosotomy", "."], "h": {"id": "C0238111", "name": "C0238111#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [10, 11]}}
{"token": ["We", "previously", "showed", "that", "prostaglandin", "(", "PG", ")", "C1414052#ent", "<e1>", "stimulates", "Ca2", "+", "influx", "from", "extracellular", "space", "activates", "C0136864#ent", "<e2>", "phosphatidylcholine", "(PC)-hydrolyzing", "phospholipase", "D", "from", "PGE2", "or", "PGF2alpha", "in", "osteoblast-like", "MC3T3-E1", "cells", "."], "h": {"id": "C1414052", "name": "C1414052#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0136864", "name": "C0136864#ent", "pos": [18, 19]}}
{"token": ["The", "C1420489#ent", "<e1>", "a", "higher", "sedimentation", "coefficient", "9", "S", ")", "than", "free", "C0067533#ent", "<e2>", "(", "5", "S", ")", "indicating", "that", "it", "might", "be", "a", "complex", "of", "P75", "and", "C0067533#ent", "<e2>", "dimers", "."], "h": {"id": "C1420489", "name": "C1420489#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0067533", "name": "C0067533#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "if", "polymorphisms", "within", "the", "Toll-like", "receptor", "4", "TLR4", ")", "C0017337#ent", "<e1>", "are", "associated", "and", "with", "C3714757#ent", "<e2>", "JIA", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [17, 18]}}
{"token": ["Twenty-three", "cases", "of", "C0019159#ent", "<e1>", "ultimately", "identified", ";", "14", "developed", "C0019158#ent", "<e2>"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [10, 11]}}
{"token": ["Hepatitis", "E", "enterically", "transmitted", "a", "self-limiting", "illness", "similar", "to", "C0019159#ent", "<e1>", ",", "unlike", "hepatitis", "A", "immunity", "to", "C0019158#ent", "<e2>", "not", "life", "long", ",", "C0019158#ent", "<e2>", "a", "disease", "of", "developing", "nations", "with", "improper", "sewage", "disposal", "and", "unclean", "water", "supplies"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [17, 18]}}
{"token": ["Because", "of", "its", "association", "with", "cancer", ",", "this", "C0079429#ent", "<e1>", "was", "named", "cancer-associated", "gene-1", "C3539760#ent", "<e2>", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539760", "name": "C3539760#ent", "pos": [14, 15]}}
{"token": ["The", "modulation", "of", "DNA", "topology", "C0012863#ent", "<e1>", "a", "crucial", "role", "during", "C1826786#ent", "<e2>", "segregation", "in", "mitosis", "and", "has", "thus", "become", "a", "highly", "attractive", "target", "for", "chemotherapeutic", "drugs"], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826786", "name": "C1826786#ent", "pos": [11, 12]}}
{"token": ["To", "examine", "whether", "the", "effects", "caused", "by", "statin", "treatment", "are", "a", "consequence", "of", "HMG-CoA", "reductase", "inhibition", ",", "we", "tested", "the", "effect", "of", "C2698196#ent", "<e1>", "on", "these", "C3541394#ent", "<e2>", "in", "mevalonate-fed", "rats", "."], "h": {"id": "C2698196", "name": "C2698196#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [26, 27]}}
{"token": ["The", "C0023660#ent", "<e1>", "concentrations", "measured", "in", "venous", "blood", "from", "the", "application", "site", "C0360032#ent", "<e2>", "low", ",", "and", "there", "were", "no", "measurable", "levels", "of", "C0023660#ent", "<e1>", "in", "simultaneous", "blood", "samples", "the", "opposite", "extremity", "."], "h": {"id": "C0360032", "name": "C0360032#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [1, 2]}}
{"token": ["In", "a", "double-blind", ",", "double-dummy", "study", ",", "the", "efficacy", "of", "topical", "5", "C0360032#ent", "<e1>", "compared", "with", "that", "of", "C0023660#ent", "<e2>", "infiltration", "in", "alleviating", "the", "pain", "of", "arterial", "cannulation"], "h": {"id": "C0360032", "name": "C0360032#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [18, 19]}}
{"token": ["This", ",", "in", "turn", ",", "triggers", "cascade", "reactions", "calcium/calmodulin", "and", "C3539645#ent", "<e1>", ",", "leading", "to", "activation", "of", "NOS", "and", "soluble", "C0018358#ent", "<e2>"], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018358", "name": "C0018358#ent", "pos": [20, 21]}}
{"token": ["Using", "these", "clones", "we", "have", "detailed", "a", "C1709995#ent", "<e1>", "physical", "map", "the", "tobacco", "C3179066#ent", "<e2>"], "h": {"id": "C1709995", "name": "C1709995#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [13, 14]}}
{"token": ["Heavily", "pigmented", "eyes", "have", "been", "shown", "to", "be", "relatively", "resistant", "to", "C0770456#ent", "<e1>", ",", "and", "present", "special", "problems", "management", "of", "C0339573#ent", "<e2>"], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [20, 21]}}
{"token": ["This", "study", "showed", "equal", "efficacy", "of", "ALT", "and", "C0770456#ent", "<e1>", "2", "%", "as", "initial", "therapy", "of", "C0339573#ent", "<e2>", "."], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "aceclidine(+", ")", "and", "C0770456#ent", "<e1>", "on", "the", "intraocular", "pressure", "the", "sphincter", "pupillae", "patients", "suffering", "from", "C0339573#ent", "<e2>", "and", "on", "the", "accommodation", "in", "normal", "young", "subjects", ",", "was", "studied", "."], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [18, 19]}}
{"token": ["Heparin", "was", "found", "to", "increase", "markedly", "the", "rate", "at", "which", "C4084825#ent", "<e1>", "activates", "C0162745#ent", "<e2>", "both", "by", "accelerating", "the", "cleavage", "of", "C0162745#ent", "<e2>", "and", "also", "by", "preventing", "its", "further", "degradation", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [13, 14]}}
{"token": ["The", "ability", "of", "C4084825#ent", "<e1>", "to", "activate", "C0162745#ent", "<e2>", "suggests", "that", "C4084825#ent", "<e1>", "plays", "an", "active", "role", "in", "matrix", "degradation", "tissue", "sites", "mast", "cells", "with", "extracellular", "procollagenase", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [7, 8]}}
{"token": ["A", "prospective", "multicenter", "clinical", "study", "conducted", "of", "87", "patients", "with", "C0457949#ent", "<e1>", "to", "degenerative", "disc", "disease", "treated", "by", "lumbar", "interbody", "fusion", "(", "C1414833#ent", "<e2>", ")", "using", "a", "newly", "designed", "ESS", "."], "h": {"id": "C0457949", "name": "C0457949#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414833", "name": "C1414833#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "report", "the", "first", "almost", "complete", "backbone", "assignment", "of", "C1704928#ent", "<e1>", "complex", "with", "C0939537#ent", "<e2>", "."], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0939537", "name": "C0939537#ent", "pos": [14, 15]}}
{"token": ["C0291772#ent", "<e1>", ",", "a", "5-HT3-receptor", "antagonist", "relieves", "C0000737#ent", "<e2>", "improves", "bowel", "function", "non-constipated", ",", "female", "patients", "with", "irritable", "bowel", "syndrome"], "h": {"id": "C0291772", "name": "C0291772#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [7, 8]}}
{"token": ["In", "plants", ",", "a", "specific", "C1416851#ent", "<e1>", "the", "catalytic", "core", "of", "Pso2p", ",", "constituting", "a", "new", "C0114615#ent", "<e2>", "which", "was", "named", "LIG6", "."], "h": {"id": "C1416851", "name": "C1416851#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0114615", "name": "C0114615#ent", "pos": [16, 17]}}
{"token": ["L82", "inhibited", "C1416851#ent", "<e1>", "L67", "inhibited", "C0114615#ent", "<e2>", "III", ",", "and", "L189", "inhibited", "C0114615#ent", "<e2>", "III", ",", "and", "IV", "in", "DNA", "joining", "assays", "with", "purified", "proteins", "in", "cell", "extract", "assays", "DNA", "replication", "base", "excision", "repair", "and", "nonhomologous", "end-joining"], "h": {"id": "C1416851", "name": "C1416851#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0114615", "name": "C0114615#ent", "pos": [6, 7]}}
{"token": ["Treatment", "for", "4", "d", "with", "0.1", "%", "RA", "cream", "2", "%", "C0272170#ent", "<e1>", "in", "RA", "vehicle", "resulted", "in", "nearly", "identical", "levels", "of", "C0041834#ent", "<e2>", "spongiosis", ",", "and", "epidermal", "thickening"], "h": {"id": "C0272170", "name": "C0272170#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [22, 23]}}
{"token": ["Beside", "C0041230#ent", "<e1>", ",", "other", "parasitic", "infections", "as", "theileriosis", ",", "C0018889#ent", "<e2>", "and", "ectoparasite", "infestation", "were", "also", "recorded", "."], "h": {"id": "C0041230", "name": "C0041230#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [10, 11]}}
{"token": ["C1741784#ent", "<e1>", ",", "the", "helicase", "mutated", "in", "C1337098#ent", "<e2>", "associates", "with", "topoisomerase", "3alpha", "RMI1", "(", "RecQ-mediated", "genome", "instability", ",", "and", "RPA", ",", "to", "form", "a", "complex", "essential", "for", "the", "maintenance", "of", "genome", "stability"], "h": {"id": "C1741784", "name": "C1741784#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1337098", "name": "C1337098#ent", "pos": [7, 8]}}
{"token": ["Initially", "the", "C0085078#ent", "<e1>", "is", "localized", "largely", "in", "the", "C4284022#ent", "<e2>", "with", "the", "disorder", "developing", "in", "other", "compartments", "of", "the", "lungs", "with", "increasing", "treatment", "time"], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4284022", "name": "C4284022#ent", "pos": [9, 10]}}
{"token": ["The", "rapidly", "growing", "number", "of", "human", "pathogens", "has", "led", "several", "investigators", "to", "regard", "C0004771#ent", "<e1>", "and", "other", "associated", "syndromes", "as", "important", "emerging", "C0005943#ent", "<e2>"], "h": {"id": "C0004771", "name": "C0004771#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [22, 23]}}
{"token": ["In", "isolated", "liver", "perfusion", "[14C]verruculogen", "was", "rapidly", "taken", "up", "by", "the", "C0023899#ent", "<e1>", "and", "metabolized", "completely", ",", "principally", "to", "the", "related", "C0040822#ent", "<e2>", "TR-2", "but", "also", "to", "a", "desoxy", "derivative", "verruculogen", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040822", "name": "C0040822#ent", "pos": [21, 22]}}
{"token": ["Eyes", "whose", "fellow", "eye", "had", "suffered", "from", "exudative", "C0025741#ent", "<e1>", "had", "more", "macular", "drusen", "hypopigmentation", "than", "C0235267#ent", "<e2>", "whose", "fellow", "eye", "had", "not", "suffered", "from", "exudative", "C0025741#ent", "<e1>", "."], "h": {"id": "C0025741", "name": "C0025741#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [16, 17]}}
{"token": ["The", "mobility", "of", "spirochetal", "lipids", "is", "altered", "after", "incubation", "with", "C1413555#ent", "<e1>", ",", "and", "the", "bactericidal", "activity", "reduced", "in", "the", "presence", "of", "C3658209#ent", "<e2>"], "h": {"id": "C1413555", "name": "C1413555#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3658209", "name": "C3658209#ent", "pos": [22, 23]}}
{"token": ["The", "human", "C1412466#ent", "<e1>", "APLP2", "is", "a", "highly", "conserved", "C1334043#ent", "<e2>", "of", "a", "sequence-specific", "DNA-binding", "mouse", "protein", "with", "a", "predicted", "function", "in", "the", "cell", "cycle"], "h": {"id": "C1412466", "name": "C1412466#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["We", "consider", "24", "cases", "of", "iatrogenic", "parkinsonism", "to", "C0016295#ent", "<e1>", ",", "evaluating", "the", "clinical", "features", "of", "the", "C0039082#ent", "<e2>", "and", "the", "improvement", "following", "withdrawal", "."], "h": {"id": "C0016295", "name": "C0016295#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [17, 18]}}
{"token": ["C0458101#ent", "<e1>", "still", "a", "controversial", "C0029896#ent", "<e2>", "and", "good", "and", "reliable", "treatment", "is", "lacking", "."], "h": {"id": "C0458101", "name": "C0458101#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [5, 6]}}
{"token": ["We", "describe", "the", "unique", "case", ",", "in", "which", "C0085652#ent", "<e1>", "exacerbation", "of", "C1419789#ent", "<e2>", "were", "developed", "8", "weeks", "after", "pegylated", "interferon", "alpha", "2a", "ribavirin", "therapy", "in", "a", "45-year-old", "woman", "."], "h": {"id": "C0085652", "name": "C0085652#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [12, 13]}}
{"token": ["Escherichia", "coli", "Staphylococcus", "epidermidis", "been", "found", "to", "be", "the", "most", "common", "C0035064#ent", "<e1>", "isolated", "from", "the", "urine", "of", "C0077906#ent", "<e2>", "patients", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0077906", "name": "C0077906#ent", "pos": [18, 19]}}
{"token": ["Therefore", "new", "C0035064#ent", "<e1>", "need", "to", "be", "assessed", "in", "the", "treatment", "of", "C0077906#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0077906", "name": "C0077906#ent", "pos": [12, 13]}}
{"token": ["10-FTHFDH", "catalyzed", "C4283758#ent", "<e1>", "oxidation", "of", "propanal", "and", "the", "hydrolysis", "of", "p-nitrophenyl", "acetate", "C1427960#ent", "<e2>", ")", "in", "a", "similar", "fashion", "to", "ALDH", "."], "h": {"id": "C4283758", "name": "C4283758#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1427960", "name": "C1427960#ent", "pos": [13, 14]}}
{"token": ["Other", "changes", "are", "histological", ",", "such", "as", "rarefaction", "of", "the", "neuropil", "and", "C0669365#ent", "<e1>", "prominence", "in", "C0023264#ent", "<e2>", "and", "spongiosis", "with", "neuronal", "loss", "gliosis", "in", "Alpers", "disease"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023264", "name": "C0023264#ent", "pos": [16, 17]}}
{"token": ["Following", "a", "pulmonary", "transplantation", "cystic", "fibrosis", "2", "patients", "exhibited", "a", "syndrome", "associating", "C0020538#ent", "<e1>", "headache", ",", "visual", "trouble", "and", "C0234533#ent", "<e2>"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [19, 20]}}
{"token": ["C1414438#ent", "<e1>", "and", "EMP1", "induced", "autophosphorylation", "of", "Janus", "kinase", "2", "JAK", "2", ",", "a", "C1421249#ent", "<e2>", "associates", "with", "EPO-R", ",", "and", "dephosphorylation", "of", "GAP-43", "in", "a", "tyrosine", "kinase-dependent", "fashion", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [14, 15]}}
{"token": ["Spinocerebellar", "ataxia", "type", "10", "C1963674#ent", "<e1>", ")", "is", "an", "autosomal", "dominant", "disorder", "by", "cerebellar", "ataxia", "C0036572#ent", "<e2>", "."], "h": {"id": "C1963674", "name": "C1963674#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [15, 16]}}
{"token": ["A", "growing", "interest", "in", "the", "beneficial", "properties", "of", "manipulating", "the", "endocannabinoid", "system", "led", "to", "the", "possible", "involvement", "of", "C3889664#ent", "<e1>", "in", "the", "control", "of", "C0014070#ent", "<e2>"], "h": {"id": "C3889664", "name": "C3889664#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014070", "name": "C0014070#ent", "pos": [24, 25]}}
{"token": ["Pretreatment", "of", "mice", "with", "either", "the", "CB1", "receptor", "agonist", "CP55940", ",", "the", "C0597607#ent", "<e1>", "AM404", ",", "or", "the", "C1414512#ent", "<e2>", "URB597", "significantly", "decreased", "or", "eliminated", "restraint-induced", "CORT", "release", "."], "h": {"id": "C0597607", "name": "C0597607#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414512", "name": "C1414512#ent", "pos": [18, 19]}}
{"token": ["The", "currently", "most", "effective", "treatment", "for", "AP", "is", "addition", "of", "sodium", "bicarbonate", "the", "water", ",", "control", "of", "C0259817#ent", "<e1>", "with", "emollients", "for", "APE", "and", "C0004057#ent", "<e2>", "for", "water-induced", "itching", "PRV", "."], "h": {"id": "C0259817", "name": "C0259817#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [24, 25]}}
{"token": ["Sialylation", "of", "C1706240#ent", "<e1>", "by", "the", "C1539865#ent", "<e2>", "prevented", "galectin-1-induced", "clustering", "of", "C1706240#ent", "<e1>", "on", "the", "T", "cell", "surface", ",", "an", "initial", "step", "in", "galectin-1", "cell", "death", "."], "h": {"id": "C1539865", "name": "C1539865#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706240", "name": "C1706240#ent", "pos": [2, 3]}}
{"token": ["T-DNA", "insertion", "mutants", "of", "C3811213#ent", "<e1>", "and", "a", "different", "C0597298#ent", "<e2>", ",", "annAt4", ",", "displayed", "hypersensitivity", "to", "osmotic", "stress", "abscisic", "acid", "ABA", ")", "during", "germination", "and", "early", "seedling", "growth", "."], "h": {"id": "C3811213", "name": "C3811213#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [9, 10]}}
{"token": ["The", "tyrosine", "phosphorylation", "C1566685#ent", "<e1>", "was", "specific", "since", "another", "C1384543#ent", "<e2>", "which", "is", "structurally", "homologous", "to", "C1566685#ent", "<e1>", ",", "was", "not", "tyrosine", "phosphorylated", "."], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1384543", "name": "C1384543#ent", "pos": [9, 10]}}
{"token": ["6-Hexadecanoylamino-4-methylumbelliferyl-beta-D-galactopyranoside", "(", "HMGal", ")", "has", "been", "shown", "to", "be", "a", "specific", "fluorogenic", "substrate", "of", "C4048351#ent", "<e1>", "and", "to", "facilitate", "the", "simple", "enzymatic", "diagnosis", "of", "C1414946#ent", "<e2>", "human", "patients", "and", "in", "twitcher", "mice"], "h": {"id": "C4048351", "name": "C4048351#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414946", "name": "C1414946#ent", "pos": [24, 25]}}
{"token": ["A", "C0017759#ent", "<e1>", "mutant", "did", "not", "synthesize", "the", "polysaccharide", "from", "C0024730#ent", "<e2>", ",", "nor", "did", "a", "glucose", "6-phosphate", "dehydrogenase", "mutant", "synthesize", "the", "polysaccharide", "from", "C0024730#ent", "<e2>", "or", "glucose", "."], "h": {"id": "C0017759", "name": "C0017759#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024730", "name": "C0024730#ent", "pos": [10, 11]}}
{"token": ["Among", "the", "differentially", "expressed", "C1417679#ent", "<e1>", "was", "a", "C0072354#ent", "<e2>", "PDI", ")", ",", "which", "is", "well", "known", "as", "a", "molecular", "chaperone", "component", "of", "signal-transduction", "pathways", "animal", "systems", "had", "not", "been", "implicated", "previously", "in", "plant", "defense", "response"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072354", "name": "C0072354#ent", "pos": [8, 9]}}
{"token": ["Fecal", "samples", "were", "examined", "for", "C0162667#ent", "<e1>", "eggs", "to", "determine", "C0018891#ent", "<e2>", "in", "each", "village", "sample"], "h": {"id": "C0162667", "name": "C0162667#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018891", "name": "C0018891#ent", "pos": [10, 11]}}
{"token": ["Using", "cotransfection", "assays", "in", "C1423526#ent", "<e1>", "we", "report", "here", "that", "C1428360#ent", "<e2>", "and", "c-Myb", "cooperatively", "stimulate", "transcription", "from", "the", "SL3", "LTR", "."], "h": {"id": "C1423526", "name": "C1423526#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [10, 11]}}
{"token": ["The", "concentration", "for", "half", "block", "K0.5", ")", "of", "the", "whole", "cell", "K", "for", "externally", "applied", "compounds", "was", "found", "to", "be", "56", "microns", "for", "C0000477#ent", "<e1>", "and", "0.3", "mM", "for", "C0046948#ent", "<e2>", "."], "h": {"id": "C0000477", "name": "C0000477#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0046948", "name": "C0046948#ent", "pos": [29, 30]}}
{"token": ["Finally", ",", "there", "are", "indications", "that", "the", "genes", "CSA", "and", "C1413753#ent", "<e1>", ",", "which", "are", "implicated", "in", "the", "human", "hereditary", "disease", "C0009207#ent", "<e2>", "may", "have", "a", "role", "in", "transcription", "."], "h": {"id": "C1413753", "name": "C1413753#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [21, 22]}}
{"token": ["These", "inhibitors", "decreased", "crocidolite-induced", "c-fos", "but", "not", "C1623430#ent", "<e1>", "levels", ",", "suggesting", "that", "C1421249#ent", "<e2>", "different", "regulatory", "roles", "asbestos-induced", "c-fos", "versus", "c-jun", "signaling", "pathways", "."], "h": {"id": "C1623430", "name": "C1623430#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "the", "recombinant", "C3889694#ent", "<e1>", "and", "C1413309#ent", "<e2>", "exhibited", "cell", "binding", "activity", "against", "CHO", "cells", "expressing", "C1413309#ent", "<e2>", "and", "C3889694#ent", "<e1>", ",", "respectively", "."], "h": {"id": "C3889694", "name": "C3889694#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [8, 9]}}
{"token": ["The", "recombinant", "C3889694#ent", "<e1>", "and", "C1413309#ent", "<e2>", "immobilized", "on", "plastic", "bound", "CHO", "transfectants", "expressing", "C1413309#ent", "<e2>", "and", "C3889694#ent", "<e1>", ",", "respectively", "."], "h": {"id": "C3889694", "name": "C3889694#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [5, 6]}}
{"token": ["C0919451#ent", "<e1>", "associated", "with", "higher", "risk", "of", "C0027849#ent", "<e2>", "[", "odds", "ratio", "OR", ")", "1.7", "(", "1.1", "-", "2.5", ")", ";", "P", "=", "0.017", "]", "."], "h": {"id": "C0919451", "name": "C0919451#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027849", "name": "C0027849#ent", "pos": [7, 8]}}
{"token": ["The", "putative", "RNA", "helicase", "sequence", "similarity", "Escherichia", "coli", "RNA", "helicase", "DEAD", ",", "C3539640#ent", "<e1>", "and", "human", "C1413963#ent", "<e2>", "and", "p54", "."], "h": {"id": "C3539640", "name": "C3539640#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413963", "name": "C1413963#ent", "pos": [16, 17]}}
{"token": ["In", "these", "cells", "HGF", "induces", "expression", "of", "C1704823#ent", "<e1>", "via", "PKC", ",", "C0034678#ent", "<e2>", "and", "mitogen", "activated", "protein", "kinase", "(", "MAPK", ")", "pathway", "."], "h": {"id": "C1704823", "name": "C1704823#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [12, 13]}}
{"token": ["BglG", "is", "inactivated", "by", "phosphorylation", "in", "the", "absence", "of", "C3539583#ent", "<e1>", "by", "BglF", ",", "the", "bgl-specific", "component", "of", "the", "C0031727#ent", "<e2>", "PTS", ")", "."], "h": {"id": "C3539583", "name": "C3539583#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}}
{"token": ["C0018099#ent", "<e1>", "six", "subjects", "were", "the", "only", "other", "significant", "adverse", "reactions", "and", "C2350656#ent", "<e2>", "was", "otherwise", "well", "tolerated", "."], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C2350656", "name": "C2350656#ent", "pos": [12, 13]}}
{"token": ["Disease-specific", "oligosaccharides", "identified", "for", "several", "oligosaccharidurias", ",", "including", "GM1", "gangliosidosis", "GM2", "gangliosidosis", "sialic", "acid", "storage", "disease", "sialidase/neuraminidase", "deficiency", "galactosialidosis", ",", "I-cell", "disease", "fucosidosis", ",", "C0017921#ent", "<e1>", "and", "Gaucher", "diseases", "and", "C0024748#ent", "<e2>", "."], "h": {"id": "C0017921", "name": "C0017921#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0024748", "name": "C0024748#ent", "pos": [30, 31]}}
{"token": ["In", "conclusion", ",", "whereas", "direct", "C2987634#ent", "<e1>", "activity", "at", "postsynaptic", "5-HT(1A)", "receptors", "attenuated", "helpless", "behaviour", "the", "antidepressant-like", "effect", "of", "C1579361#ent", "<e2>", "was", "found", "to", "be", "independent", "of", "their", "actions", "on", "either", "5-HT(1A)", "receptor", "function", "extracellular", "5-HT", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1579361", "name": "C1579361#ent", "pos": [19, 20]}}
{"token": ["Compounds", "with", "5-HT(1A", ")", "C2987634#ent", "<e1>", "properties", "have", "been", "proposed", "as", "adjuvant", "agents", "patients", "continuing", "with", "C1579361#ent", "<e2>", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1579361", "name": "C1579361#ent", "pos": [16, 17]}}
{"token": ["The", "percentage", "decrease", "in", "CVR", "was", "greater", "than", "that", "in", "C1420877#ent", "<e1>", "with", "KRN4884", "and", "C0244960#ent", "<e2>", ",", "but", "nilvadipine", "and", "nifedipine", "showed", "no", "significant", "between", "CVR", "and", "C1420877#ent", "<e1>", "in", "percentage", "decreases", "."], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0244960", "name": "C0244960#ent", "pos": [15, 16]}}
{"token": ["Increased", "incidences", "of", "Kaposi's", "sarcoma", "lymphoid", "malignancies", "been", "observed", "in", "patients", "with", "C0030807#ent", "<e1>", ",", "and", "the", "human", "herpesvirus", "8", "C3891713#ent", "<e2>", ")", "is", "very", "strongly", "associated", "with", "tumors", "."], "h": {"id": "C0030807", "name": "C0030807#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3891713", "name": "C3891713#ent", "pos": [20, 21]}}
{"token": ["We", "found", "an", "ultraviolet", "A", "UVA", ")", "irradiation-dependent", "increase", "in", "the", "weights", "and", "cell", "counts", "the", "auricular", "lymph", "nodes", "application", "of", "8-methoxypsoralen", ",", "C0077019#ent", "<e1>", ",", "trichlorosalicylanilide", ",", "chlorpromazine", "and", "C0033405#ent", "<e2>", "."], "h": {"id": "C0077019", "name": "C0077019#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0033405", "name": "C0033405#ent", "pos": [30, 31]}}
{"token": ["The", "capacity", "of", "C1332821#ent", "<e1>", "to", "activate", "these", "MAP", "kinases", "synergistically", "amplified", "by", "coligating", "C1413206#ent", "<e2>", ",", "and", "this", "effect", "requires", "that", "C1413206#ent", "<e2>", "be", "juxtaposed", "to", "C1332821#ent", "<e1>", "."], "h": {"id": "C1332821", "name": "C1332821#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413206", "name": "C1413206#ent", "pos": [14, 15]}}
{"token": ["The", "contractile", "response", "C2698414#ent", "<e1>", "was", "inhibited", "by", "C0700620#ent", "<e2>", "pA2", "7.53", ")", "but", "unaffected", "by", "PD", "123.177", "(", "pA2", "less", "than", "5", ")", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0700620", "name": "C0700620#ent", "pos": [8, 9]}}
{"token": ["Neither", "C0011777#ent", "<e1>", "nor", "the", "drug", "influenced", "the", "cellular", "quantity", "C1538577#ent", "<e2>", "molecules", ",", "tested", "immunochemically", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538577", "name": "C1538577#ent", "pos": [10, 11]}}
{"token": ["a", "selective", "C3537230#ent", "<e1>", "had", "no", "effect", "on", "the", "C0003449#ent", "<e2>", "morphine", "."], "h": {"id": "C3537230", "name": "C3537230#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003449", "name": "C0003449#ent", "pos": [9, 10]}}
{"token": ["C3537230#ent", "<e1>", "such", "as", "codeine", "are", "commonly", "used", "as", "C0003449#ent", "<e2>", "are", "among", "the", "most", "widely", "administered", "drugs", "in", "the", "world", "."], "h": {"id": "C3537230", "name": "C3537230#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003449", "name": "C0003449#ent", "pos": [9, 10]}}
{"token": ["This", "work", "aimed", "to", "examine", "the", "association", "of", "episode", "C0720099#ent", "<e1>", "with", "symptoms", "and", "clinical", "course", "primary", "care", "consulters", "with", "low", "back", "pain", "C1416801#ent", "<e2>", ")", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416801", "name": "C1416801#ent", "pos": [23, 24]}}
{"token": ["Information", "on", "prognostic", "factors", "C0720099#ent", "<e1>", "of", "sick", "leave", "due", "to", "low-back", "pain", "(", "C1416801#ent", "<e2>", ")", "is", "growing", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416801", "name": "C1416801#ent", "pos": [14, 15]}}
{"token": ["Toxicity", "included", "mild", "myelosupression", "C0003123#ent", "<e1>", "vomiting", ",", "and", "severe", "C0038358#ent", "<e2>", "pulmonary", "fibrosis"], "h": {"id": "C0003123", "name": "C0003123#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [10, 11]}}
{"token": ["Since", "the", "cloning", "of", "the", "type", "II", "C1418616#ent", "<e1>", "in", "1989", "from", "C0038013#ent", "<e2>", "synovial", "fluid", "a", "direct", "or", "indirect", "participation", "of", "type", "II", "C1418616#ent", "<e1>", "in", "the", "production", "of", "lipid", "mediators", "been", "purposed", "."], "h": {"id": "C1418616", "name": "C1418616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [12, 13]}}
{"token": ["Two", "groups", "of", "10", "patients", "with", "C0020538#ent", "<e1>", "studied", "by", "respiratory", "function", "tests", "and", "after", "acute", "administration", "diazoxide", "or", "C0016860#ent", "<e2>", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "scoparone", "(", "Sco", ")", ",", "tetramethylpyrazine", "(", "C1706000#ent", "<e1>", ")", ",", "and", "papaverine", "(", "C1423108#ent", "<e2>", ")", "on", "hemodynamics", "were", "compared", "in", "anesthetized", "rabbits", "."], "h": {"id": "C1706000", "name": "C1706000#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [17, 18]}}
{"token": ["After", "2", "day", "treatment", ",", "C0006931#ent", "<e1>", "but", "not", "C0073081#ent", "<e2>", "inhibited", "the", "proliferation", "and", "altered", "the", "differentiation", "of", "the", "cells", "and", "produced", "apoptosis", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0073081", "name": "C0073081#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "C0006931#ent", "<e1>", "were", "abolished", "when", "preparations", "were", "exposed", "to", "concentrations", "of", "C0073081#ent", "<e2>", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073081", "name": "C0073081#ent", "pos": [14, 15]}}
{"token": ["Cytokine", "mediated", "cell", "immunity", "the", "main", "mode", "of", "C1519680#ent", "<e1>", "organism", ",", "and", "the", "disequilibrium", "of", "C1333196#ent", "<e2>", "network", "is", "the", "main", "cause", "of", "tumor", "cells", "immunologic", "surveillance"], "h": {"id": "C1519680", "name": "C1519680#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [16, 17]}}
{"token": ["Following", "intraocular", "injection", "of", "C0360097#ent", "<e1>", ",", "epinephrine", ",", "or", "C0020197#ent", "<e2>", "permanent", "damage", "the", "retina", "or", "irreversible", "reduction", "in", "visual", "acuity", "observed", "neither", "in", "the", "first", "2", "patients", "nor", "in", "the", "animals", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020197", "name": "C0020197#ent", "pos": [10, 11]}}
{"token": ["Drugs", "such", "as", "hydrocortisone", ",", "dexamethasone", ",", "C0360097#ent", "<e1>", ",", "bupivacaine", ",", "phentolamine", ",", "and", "C0020197#ent", "<e2>", "were", "ineffective", "in", "modifying", "Adriamycin", "skin", "necrosis"], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020197", "name": "C0020197#ent", "pos": [15, 16]}}
{"token": ["C0022245#ent", "<e1>", "and", "atenolol", "had", "no", "effect", "the", "concentration", "of", "C0011685#ent", "<e2>", "in", "brain", "regions"], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [10, 11]}}
{"token": ["The", "beta1-antagonist", "atenolol", "(", "1.0", "micromol/l", ")", "potentiated", "the", "facilitatory", "effects", "C0022245#ent", "<e1>", "in", "the", "presence", "of", "C0011685#ent", "<e2>", "and", "corticosterone", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [17, 18]}}
{"token": ["Cerebrospinal", "fluid", "CSF", ")", "samples", "were", "evaluated", "in", "an", "immunoglobulin", "M", "enzyme-linked", "immunosorbent", "assay", "IgM", "ELISA", ")", "for", "C0153188#ent", "<e1>", "with", "sonic", "extracts", "of", "Treponema", "pallidum", "coated", "on", "C0142915#ent", "<e2>"], "h": {"id": "C0153188", "name": "C0153188#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0142915", "name": "C0142915#ent", "pos": [28, 29]}}
{"token": ["administration", "of", "adrenergic", "agonists", "phenylephrine", ",", "an", "alpha1-adrenergic", "receptor", "agonist", "clenbuterol", ",", "a", "C2917450#ent", "<e1>", "noradrenaline", "acting", "predominantly", "on", "alpha1-adrenoreceptors", ",", "and", "cholinergic", "agonists", "C0006945#ent", "<e2>", ",", "a", "predominant", "muscarinic", "receptor", "agonist", "nicotine", ",", "a", "nicotinic", "receptor", "agonist"], "h": {"id": "C2917450", "name": "C2917450#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [24, 25]}}
{"token": ["TRPC4", "downregulation", "was", "also", "achieved", "by", "increasing", "extracellular", "calcium", "and", "was", "attenuated", "by", "gadolinium", "and", "C0246694#ent", "<e1>", ",", "suggesting", "that", "C1421171#ent", "<e2>", "regulated", "by", "intracellular", "calcium", "concentration", "and/or", "the", "ubiquitin-proteasome", "pathway"], "h": {"id": "C0246694", "name": "C0246694#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1421171", "name": "C1421171#ent", "pos": [20, 21]}}
{"token": ["These", "C1417679#ent", "<e1>", ",", "designated", "Agm1", "and", "C3889253#ent", "<e2>", ",", "encode", "maltase-like", "polypeptides", "of", "498", "and", "599", "residues", ",", "respectively", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889253", "name": "C3889253#ent", "pos": [7, 8]}}
{"token": ["The", "effects", "of", "agents", "reported", "to", "inhibit", "phospholipase", "A2", "activity", "C0282331#ent", "<e1>", ",", "spermine", "and", "C0021246#ent", "<e2>", ")", ",", "tubocurarine", "and", "dantrolene", "were", "examined", "on", "these", "contractures", "."], "h": {"id": "C0282331", "name": "C0282331#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [15, 16]}}
{"token": ["beta-Glucuronidase", "was", "also", "determined", "at", "regular", "intervals", "28", "patients", "with", "C0524909#ent", "<e1>", "investigate", "the", "clinical", "usefulness", "of", "serial", "measurement", "of", "the", "C0014442#ent", "<e2>", "to", "predict", "the", "histological", "progression", "hepatitis", "."], "h": {"id": "C0524909", "name": "C0524909#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["C1314771#ent", "<e1>", ",", "also", "known", "as", "C1412206#ent", "<e2>", ",", "is", "expressed", "mainly", "in", "cells", "of", "the", "immune", "system", "such", "as", "monocytes", ",", "neutrophils", ",", "eosinophils", ",", "dendritic", "cells", "and", "B", "cells"], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412206", "name": "C1412206#ent", "pos": [6, 7]}}
{"token": ["We", "present", "structural", "and", "C1119970#ent", "<e1>", "evidence", "for", "allosteric", "effects", "a", "PDZ", "domain", "PDZ2", "from", "the", "tyrosine", "phosphatase", "C1419096#ent", "<e2>", ",", "upon", "binding", "to", "a", "target", "peptide", "."], "h": {"id": "C1119970", "name": "C1119970#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419096", "name": "C1419096#ent", "pos": [18, 19]}}
{"token": ["This", "report", "describes", "C0022322#ent", "<e1>", "toxicosis", "and", "its", "treatment", "with", "C0027680#ent", "<e2>", "2", "kittens", "and", "an", "adult", "cat", "that", "had", "been", "massively", "overdosed", "by", "their", "owners", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027680", "name": "C0027680#ent", "pos": [10, 11]}}
{"token": ["When", "compared", "with", "placebo", ",", "C0022860#ent", "<e1>", "significantly", "reduced", "the", "effect", "of", "C0001927#ent", "<e2>", "FEV1", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [12, 13]}}
{"token": ["Concurrent", "resting", "and", "C0040822#ent", "<e1>", "patients", "with", "C0030567#ent", "<e2>", "monitored", "using", "transducers", "responding", "to", "angular", "velocity", "of", "rotation", "."], "h": {"id": "C0040822", "name": "C0040822#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [7, 8]}}
{"token": ["Principal", "features", "of", "FXTAS", "include", "progressive", "C0040822#ent", "<e1>", "gait", "ataxia", "with", "associated", "features", "of", "C0030567#ent", "<e2>", ",", "peripheral", "neuropathy", "dysautonomia", ",", "and", "cognitive", "decline"], "h": {"id": "C0040822", "name": "C0040822#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [14, 15]}}
{"token": ["The", "Kr\u00fcppel-like", "zinc", "finger", "protein", "Gli-similar", "3", "(", "Glis3", ")", "plays", "a", "critical", "role", "in", "pancreatic", "development", "has", "been", "implicated", "in", "a", "C0039082#ent", "<e1>", "with", "neonatal", "diabetes", "hypothyroidism", "(", "C1857775#ent", "<e2>", ")", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1857775", "name": "C1857775#ent", "pos": [29, 30]}}
{"token": ["In", "a", "conventional", "4-h", "C1445745#ent", "<e1>", "release", "assay", ",", "SEB-activated", "CD8", "T", "cells", "are", "efficient", "C1336644#ent", "<e2>", ",", "whereas", "CD4", "T", "cells", "not", "."], "h": {"id": "C1445745", "name": "C1445745#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336644", "name": "C1336644#ent", "pos": [15, 16]}}
{"token": ["Relief", "of", "C0002962#ent", "<e1>", "been", "achieved", "in", "78", "%", "and", "of", "C0023212#ent", "<e2>", "75", "%", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023212", "name": "C0023212#ent", "pos": [11, 12]}}
{"token": ["The", "C1333903#ent", "<e1>", "Y", "(", "HMGI/Y", ")", "are", "abundant", "components", "of", "C0008546#ent", "<e2>", "."], "h": {"id": "C1333903", "name": "C1333903#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [11, 12]}}
{"token": ["Hyper-phosphorylation", "(", "at", "least", "five", "phosphate", "groups/HMGA1a", "molecule", ")", "occurs", "at", "the", "early", "apoptotic", "stages", "is", "probably", "related", "to", "C1333903#ent", "<e1>", "displacement", "from", "DNA", "and", "C0008546#ent", "<e2>", "release", "from", "the", "nuclear", "scaffold"], "h": {"id": "C1333903", "name": "C1333903#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [25, 26]}}
{"token": ["We", "report", "a", "10-year-old", "immunocompetent", "girl", "with", "C0270697#ent", "<e1>", "and", "chronic", "sinusitis", "who", "developed", "a", "C0221069#ent", "<e2>", "streptococcal", "milleri", "sphenoidal", "osteomyelitis"], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221069", "name": "C0221069#ent", "pos": [15, 16]}}
{"token": ["Response", "patterns", "of", "hallucinogens", "could", "be", "differentiated", "from", "3", "C0002763#ent", "<e1>", "and", "from", "a", "C0301360#ent", "<e2>", "lacks", "hallucinogenic", "activity"], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0301360", "name": "C0301360#ent", "pos": [14, 15]}}
{"token": ["C4284136#ent", "<e1>", "mRNA", "contained", "a", "2112", "bp", "C0079941#ent", "<e2>", "encoding", "703", "amino", "acids", "with", "a", "predicted", "protein", "size", "78.8", "kDa", "."], "h": {"id": "C4284136", "name": "C4284136#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}}
{"token": ["Thus", "C4284136#ent", "<e1>", "mutations", "in", "the", "first", "C0079941#ent", "<e2>", "irrelevant", "for", "sARL", "development", "in", "cynomolgus", "monkeys", "for", "tumorigenicity", "of", "sARL", "cell", "lines", "."], "h": {"id": "C4284136", "name": "C4284136#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}}
{"token": ["We", "suggest", "a", "model", "for", "the", "ordered", "binding", "of", "phosphorylase", "b", "phosphorylase", "kinase", "the", "glycogen", "particle", "explains", "the", "increase", "in", "the", "tightness", "of", "C0033640#ent", "<e1>", "glycogen", "in", "the", "presence", "of", "C0917783#ent", "<e2>"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0917783", "name": "C0917783#ent", "pos": [30, 31]}}
{"token": ["Whereas", "the", "levels", "of", "cAMP", "and", "the", "activity", "ratio", "C0033640#ent", "<e1>", "of", "phosphorylase", "kinase", "and", "of", "C0917783#ent", "<e2>", "returned", "to", "aerobic", "values", "the", "nonischemic", "area", ",", "these", "parameters", "remained", "elevated", "in", "the", "ischemic", "area"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0917783", "name": "C0917783#ent", "pos": [16, 17]}}
{"token": ["In", "vitro", "phosphorylation", "was", "carried", "out", "by", "C0033640#ent", "<e1>", "associated", "with", "organelles", "and", "[", "gamma-(32", ")", "P]ATP", "as", "the", "C0917783#ent", "<e2>"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0917783", "name": "C0917783#ent", "pos": [19, 20]}}
{"token": ["Inhibition", "of", "the", "C0669372#ent", "<e1>", "neutralizing", "antibodies", "TNF-alpha", "also", "reduced", "C1333908#ent", "<e2>", "release", "stimulated", "by", "HSP65", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333908", "name": "C1333908#ent", "pos": [10, 11]}}
{"token": ["Infection", "with", "HTLV-1", "may", "be", "directly", "involved", "in", "the", "etiology", "and/or", "pathogenesis", "of", "an", "C0035012#ent", "<e1>", "condition", "similar", "to", "C0003873#ent", "<e2>"], "h": {"id": "C0035012", "name": "C0035012#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["A", "6-year-old", "boy", "with", "nail", "changes", "compatible", "with", "those", "seen", "in", "C0035012#ent", "<e1>", "and", "his", "father", "with", "C0003873#ent", "<e2>", "recurrent", "anterior", "uveitis", "amyloidosis", ",", "and", "a", "transplanted", "kidney", "described", "."], "h": {"id": "C0035012", "name": "C0035012#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}}
{"token": ["Polymorphic", "microsatellite", "open-reading", "frame", "C3715179#ent", "<e1>", ")", "sites", "in", "the", "C4082486#ent", "<e2>", "PRNP", ")", "were", "analysed", "in", "eight", "sheep", "breeds", "."], "h": {"id": "C3715179", "name": "C3715179#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [10, 11]}}
{"token": ["The", "number", "of", "responders", "was", "greatest", "at", "C1706471#ent", "<e1>", "(", "P", "less", "than", ".03", ")", "with", "C1416970#ent", "<e2>", "and", "AGE2", "being", "similar", "."], "h": {"id": "C1706471", "name": "C1706471#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416970", "name": "C1416970#ent", "pos": [16, 17]}}
{"token": ["Further", "investigation", "is", "necessary", "to", "elicit", "a", "definite", "answer", "to", "whether", "C0886658#ent", "<e1>", "administered", "after", "bronchial", "challenge", "has", "an", "effect", "on", "C0004096#ent", "<e2>"], "h": {"id": "C0886658", "name": "C0886658#ent", "pos": [11, 12]}, "relation": "may_prevent", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}}
{"token": ["Additionally", ",", "assimilation", "of", "3", "of", "these", "12", "C0524928#ent", "<e1>", "substrates", "(", "maltose", ",", "C0001056#ent", "<e2>", ",", "and", "phenylacetate", ")", "was", "tested", "with", "the", "API", "20", "NE", "identification", "system", "bioM\u00e9rieux", ")", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001056", "name": "C0001056#ent", "pos": [14, 15]}}
{"token": ["A", "model", "for", "the", "3-D", "structure", "Enterococcus", "faecalis", "D-Ala", "D-Ala", "ligase", "was", "produced", "using", "the", "X-ray", "structure", "the", "Escherichia", "coli", "C0014442#ent", "<e1>", "complexed", "with", "ADP", "and", "the", "C0597217#ent", "<e2>", "a", "template", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0597217", "name": "C0597217#ent", "pos": [27, 28]}}
{"token": ["The", "increase", "in", "MCD", "activity", "was", "markedly", "diminished", "when", "immunopurified", "C0014442#ent", "<e1>", "was", "treated", "with", "protein", "phosphatase", "2A", "when", "C0597217#ent", "<e2>", "omitted", "from", "the", "homogenizing", "solution", "and", "assay", "mixture"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0597217", "name": "C0597217#ent", "pos": [19, 20]}}
{"token": ["BaP", "induces", "C1705323#ent", "<e1>", "expression", ",", "and", "an", "interaction", "between", "BaP", "and", "C2936882#ent", "<e2>", "in", "relation", "to", "C1705323#ent", "<e1>", "expression", "is", "suspected", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [12, 13]}}
{"token": ["Dubin-Johnson", "syndrome", "C0022350#ent", "<e1>", ")", "is", "an", "autosomal", "recessive", "disease", "by", "C0268307#ent", "<e2>"], "h": {"id": "C0022350", "name": "C0022350#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0268307", "name": "C0268307#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "an", "adolescent", "with", "typical", "C0085652#ent", "<e1>", "presented", "with", "cavitary", "pneumonia", "responded", "completely", "to", "C0304604#ent", "<e2>"], "h": {"id": "C0085652", "name": "C0085652#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0304604", "name": "C0304604#ent", "pos": [15, 16]}}
{"token": ["C0085652#ent", "<e1>", "treatment", ",", "including", "C0304604#ent", "<e2>", "topical", "0.01", "%", "tacrolimus", "twice", "daily", "covered", "with", "nonadhesive", "gauze", "and", "compression", "wrapping", ",", "was", "started", "."], "h": {"id": "C0085652", "name": "C0085652#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304604", "name": "C0304604#ent", "pos": [5, 6]}}
{"token": ["C0033487#ent", "<e1>", "was", "less", "potent", "as", "an", "C1422492#ent", "<e2>", "of", "alpha1(K278M)beta2gamma2", "receptors", "."], "h": {"id": "C0033487", "name": "C0033487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [7, 8]}}
{"token": ["In", "fact", ",", "a", "trial", "treating", "patients", "with", "C0017612#ent", "<e1>", "memantine", ",", "a", "C1254351#ent", "<e2>", "approved", "for", "the", "treatment", "of", "Alzheimer's", "disease", "has", "recently", "been", "completed", "."], "h": {"id": "C0017612", "name": "C0017612#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}}
{"token": ["Six", "months", "of", "twice", "weekly", "directly", "observed", "C0022209#ent", "<e1>", "and", "rifam-picin", "treatment", "of", "latent", "tuberculosis", "C0077025#ent", "<e2>", ")", "infection", "was", "implemented", "to", "improve", "the", "outcome", "of", "treatment", "."], "h": {"id": "C0022209", "name": "C0022209#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0077025", "name": "C0077025#ent", "pos": [15, 16]}}
{"token": ["In", "severe", "C0030567#ent", "<e1>", ",", "the", "neuronal", "activity", "the", "output", "of", "the", "basal", "ganglia", "C0017759#ent", "<e2>", ")", "is", "excessive", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017759", "name": "C0017759#ent", "pos": [14, 15]}}
{"token": ["Activities", "of", "fatty", "acid", "synthetase", "C1417092#ent", "<e1>", "these", "tissues", "were", "also", "unaffected", "by", "C0055730#ent", "<e2>", "."], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0055730", "name": "C0055730#ent", "pos": [13, 14]}}
{"token": ["To", "acquire", "a", "better", "understanding", "of", "the", "interaction", "of", "WRN", "and", "BLM", "with", "C0252912#ent", "<e1>", ",", "we", "have", "mapped", "the", "C0252912#ent", "<e1>", "binding", "site", "the", "two", "C0084304#ent", "<e1>"], "h": {"id": "C0252912", "name": "C0252912#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0084304", "name": "C0084304#ent", "pos": [26, 27]}}
{"token": ["We", "report", "on", "an", "adult", "patient", "who", "suffered", "from", "C0011854#ent", "<e1>", "and", "subsequently", "developed", "PHH", "caused", "by", "C0027773#ent", "<e2>"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027773", "name": "C0027773#ent", "pos": [17, 18]}}
{"token": ["GM-CSF", "also", "increases", "expression", "of", "the", "costimulatory", "molecules", "C1413243#ent", "<e1>", "and", "CD40", ",", "but", "not", "the", "differentiation", "marker", "CD1a", "or", "C1414555#ent", "<e2>", "."], "h": {"id": "C1413243", "name": "C1413243#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414555", "name": "C1414555#ent", "pos": [20, 21]}}
{"token": ["Differential", "diagnosis", "include", "C0025289#ent", "<e1>", ",", "epilepsy", ",", "hypoglycemia", ",", "and", "encephalopathies", "and", "other", "C0007682#ent", "<e2>"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [14, 15]}}
{"token": ["Double", "immunostaining", "of", "C3890775#ent", "<e1>", "and", "proliferating", "cell", "nuclear", "antigen", "C1366837#ent", "<e2>", ")", "showed", "that", "C3890775#ent", "<e1>", "was", "co-localized", "with", "C1366837#ent", "<e2>", "."], "h": {"id": "C3890775", "name": "C3890775#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [10, 11]}}
{"token": ["Proanthocyanidins", "(", "PAs", ")", "are", "a", "group", "of", "C3540801#ent", "<e1>", "consisting", "of", "oligomers", "based", "on", "C0059438#ent", "<e2>", "monomeric", "units", "."], "h": {"id": "C3540801", "name": "C3540801#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059438", "name": "C0059438#ent", "pos": [15, 16]}}
{"token": ["Binding", "activity", "lost", "after", "incubation", "with", "proteolytic", "enzymes", "trypsin", ",", "C0033417#ent", "<e1>", ")", "but", "not", "with", "DNAase", ",", "lipase", ",", "C0962754#ent", "<e2>", "and", "neuraminidase", "."], "h": {"id": "C0033417", "name": "C0033417#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "the", "induction", "of", "C0132555#ent", "<e1>", "macrophages", "stimulated", "with", "lipopolysaccharide", "and", "gamma", "interferon", "not", "dependent", "on", "C1706351#ent", "<e2>", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706351", "name": "C1706351#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "in", "the", "majority", "of", "patients", "with", "acute", "or", "chronic", "supraventricular", "arrhythmias", "C0026265#ent", "<e1>", "cardioversion", "promptly", "restores", "effective", "atrial", "contraction", "decreases", "C1420423#ent", "<e2>", "size", ",", "and", "results", "in", "substantial", "hemodynamic", "benefit", "."], "h": {"id": "C0026265", "name": "C0026265#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [22, 23]}}
{"token": ["We", "compared", "C1420276#ent", "<e1>", "112", "and", "C1420276#ent", "<e1>", "140", "expression", "levels", "the", "prefrontal", "cortices", "six", "DLB", "patients", ",", "eight", "C0002395#ent", "<e1>", "AD", ")", "patients", ",", "and", "six", "control", "subjects"], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}}
{"token": ["Finally", ",", "the", "amyloidogenic", "fragment", "61", "-", "95", "amino", "acids", "C1420276#ent", "<e1>", "is", "the", "non-Abeta", "component", "of", "senile", "plaque", "amyloid", "in", "C0002395#ent", "<e2>"], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [10, 11]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [21, 22]}}
{"token": ["AA-increase", "in", "vascular", "6-keto-PGF1", "alpha", "reduced", "by", "C0011777#ent", "<e1>", ",", "indomethacin", "and", "phenidone", "but", "not", "by", "C0751039#ent", "<e2>", ";", "only", "phenidone", "reduced", "LTB4", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [16, 17]}}
{"token": ["We", "studied", "human", "orbital", "fibroblast", "OF", ")", "interleukin-6", "(", "IL-6", ")", "gene", "expression", "response", "to", "proinflammatory", "stimuli", "the", "effects", "of", "C0011777#ent", "<e1>", "(", "DEX", ")", "and", "cyclosporin", "A", "C0751039#ent", "<e2>", ")", "on", "cytokine-stimulated", "OF", "IL-6", "gene", "expression"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [28, 29]}}
{"token": ["The", "effect", "of", "C0011777#ent", "<e1>", "(", "DEX", ")", "and", "cyclosporin", "A", "C0751039#ent", "<e2>", ")", "on", "OF", "IL-8", "and", "MCP-1", "were", "examined", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [11, 12]}}
{"token": ["This", "C1848862#ent", "<e1>", "may", "be", "a", "variant", "of", "C0026603#ent", "<e2>", "although", "this", "possibility", "has", "been", "questioned", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [8, 9]}}
{"token": ["S-thiolation", "of", "C0917783#ent", "<e1>", "had", "no", "observable", "effect", "on", "any", "activity", "parameter", ",", "but", "it", "effectively", "prevented", "binding", "of", "C0917783#ent", "<e1>", "to", "high-molecular-weight", "glycogen", ",", "probably", "at", "the", "C0017920#ent", "<e1>", "C0917783#ent", "<e1>", "."], "h": {"id": "C0917783", "name": "C0917783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [28, 29]}}
{"token": ["C2746076#ent", "<e1>", "subtypes", "are", "coded", "for", "by", "three", "C1417679#ent", "<e2>", "."], "h": {"id": "C2746076", "name": "C2746076#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}}
{"token": ["Linear", "and", "cyclic", "peptides", "from", "the", "sequences", "of", "LFA-1", ",", "C1706544#ent", "<e1>", ",", "ICAM-2", ",", "VCAM-1", ",", "and", "FN", "C1412521#ent", "<e2>", "have", "been", "shown", "to", "have", "inhibitory", "effects", "in", "vitro", "in", "vivo"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412521", "name": "C1412521#ent", "pos": [19, 20]}}
{"token": ["formate", ">", "C0000979#ent", "<e1>", ")", "indicated", "strong", "binding", "of", "weakly", "C0008161#ent", "<e2>", "chaotropic", "ions", "."], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008161", "name": "C0008161#ent", "pos": [10, 11]}}
{"token": ["Natriuretic", "peptides", "C1836075#ent", "<e1>", ")", "may", "work", "as", "neuromodulators", "through", "their", "C1823597#ent", "<e2>", "NP", "receptors", "NPRs", ")", "]", "."], "h": {"id": "C1836075", "name": "C1836075#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1823597", "name": "C1823597#ent", "pos": [11, 12]}}
{"token": ["In", "view", "of", "the", "present", "findings", "we", "hypothesize", "that", "C0002570#ent", "<e1>", "other", "than", "C2986617#ent", "<e2>", "predominantly", "contribute", "to", "the", "observed", "pro-angiogenic", "effect", "of", "bestatin", "in", "a", "fibrin", "matrix"], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986617", "name": "C2986617#ent", "pos": [13, 14]}}
{"token": ["These", "phenotypic", "similarities", "have", "led", "to", "C1425433#ent", "<e1>", "being", "proposed", "as", "an", "acceptable", "genetic", "model", "C0025741#ent", "<e2>", "."], "h": {"id": "C1425433", "name": "C1425433#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025741", "name": "C0025741#ent", "pos": [15, 16]}}
{"token": ["Protection", "by", "RHLF", "of", "the", "intestinal", "tract", "NSAIDs", "appears", "to", "be", "linked", "to", "attenuation", "of", "C1417739#ent", "<e1>", "the", "intestine", ",", "and", "is", "independent", "of", "C0356622#ent", "<e2>", "and", "nitric", "oxide"], "h": {"id": "C1417739", "name": "C1417739#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [24, 25]}}
{"token": ["Their", "corner", "frequency", "increased", "with", "characteristic", "frequency", "C3811819#ent", "<e1>", ")", ",", "but", "changed", "little", "for", "C0015674#ent", "<e2>", "above", "10", "kHz", "."], "h": {"id": "C3811819", "name": "C3811819#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [15, 16]}}
{"token": ["C1412446#ent", "<e1>", "even", "at", "a", "low", "dose", "beta-adrenergic", "effects", "on", "flow", "rate", "C0036091#ent", "<e2>", "pretreatment", "of", "rats", "with", "PROP", "(", "1", "mg/kg", ")", "20", "min", "before", "C1412446#ent", "<e1>", "(", "5", "mg/kg", ",", "i.p", ".", ")"], "h": {"id": "C1412446", "name": "C1412446#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [12, 13]}}
{"token": ["C0010656#ent", "<e1>", "encoded", "by", "at", "least", "seven", "C1417679#ent", "<e2>", ",", "several", "of", "which", "are", "found", "in", "E.", "histolytica", "not", "E.", "dispar", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}}
{"token": ["Previous", "studies", "showed", "that", "murine", "C0064833#ent", "<e1>", "PMNs", ")", "lyze", "tumour", "cells", "the", "presence", "of", "wheat", "germ", "agglutinin", "C3536807#ent", "<e2>", "D."], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536807", "name": "C3536807#ent", "pos": [18, 19]}}
{"token": ["A", "transposon", "mutant", "PCL1445", ",", "strain", "PCL1436", ",", "which", "lacks", "the", "two", "surface-active", "peaks", "appeared", "to", "be", "mutated", "in", "an", "open", "reading", "frame", "ORF", ")", "with", "C2917660#ent", "<e1>", "homology", "to", "various", "C2266975#ent", "<e2>"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C2266975", "name": "C2266975#ent", "pos": [31, 32]}}
{"token": ["Significant", "increases", "in", "urinary", "excretion", "chloride", ",", "C2936886#ent", "<e1>", ",", "and", "phosphorus", "were", "also", "seen", "during", "C0051989#ent", "<e2>", "infusion", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0051989", "name": "C0051989#ent", "pos": [16, 17]}}
{"token": ["Neither", "GDEE", "nor", "D-AP5", "blocked", "the", "depressor", "responses", "C1456795#ent", "<e1>", "and", "two", "nerve", "activities", "elicited", "from", "C1421450#ent", "<e2>", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421450", "name": "C1421450#ent", "pos": [16, 17]}}
{"token": ["We", "compared", "the", "effects", "of", "C0019139#ent", "<e1>", "LMWH", ")", ",", "bemiparin", ",", "and", "C0282471#ent", "<e2>", "with", "unfractionated", "heparin", "UFH", ")", "on", "the", "platelet", "subendothelium", "interaction", "under", "flow", "conditions", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0282471", "name": "C0282471#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "C0002502#ent", "<e1>", "and", "gabexate", "mesylate", "represent", "useful", "model", "compounds", "the", "development", "of", "C1517755#ent", "<e2>", "mammalian", "copper", "amine", "oxidase", "which", "may", "be", "important", "in", "view", "of", "the", "potential", "use", "of", "plant", "copper", "amine", "oxidase", "drugs", "."], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1517755", "name": "C1517755#ent", "pos": [14, 15]}}
{"token": ["To", "test", "our", "hypothesis", ",", "we", "investigated", "the", "effect", "of", "disulfiram", ",", "an", "C3850110#ent", "<e1>", "and", "its", "metabolite", ",", "C0012422#ent", "<e2>", ",", "on", "VP-16-induced", "DNA", "damage", "in", "L1210", "cells", "."], "h": {"id": "C3850110", "name": "C3850110#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012422", "name": "C0012422#ent", "pos": [19, 20]}}
{"token": ["The", "similarity", "of", "the", "results", "in", "the", "elderly", "and", "the", "C2347281#ent", "<e1>", "subjects", "suggest", "that", "C0004153#ent", "<e2>", "is", "an", "early", "aging", "process", "."], "h": {"id": "C2347281", "name": "C2347281#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [15, 16]}}
{"token": ["DNA", "sequences", "around", "the", "deletion", "end", "points", "in", "the", "variable", "regions", "that", "the", "deletion", "C1951340#ent", "<e1>", "may", "take", "place", "by", "both", "C1334043#ent", "<e2>", "and", "nonhomologous", "recombination"], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [21, 22]}}
{"token": ["TRK-fused", "gene", "TFG", ")", "was", "first", "identified", "as", "a", "partner", "of", "C0919487#ent", "<e1>", "in", "generating", "the", "C3274808#ent", "<e2>", "and", "is", "also", "involved", "in", "oncogenic", "rearrangements", "ALK", "in", "anaplastic", "lymphoma", "NOR1", "in", "mixoid", "chondrosarcoma"], "h": {"id": "C0919487", "name": "C0919487#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274808", "name": "C3274808#ent", "pos": [16, 17]}}
{"token": ["Tyrosine", "1356", "is", "essential", "for", "the", "recruitment", "of", "multiple", "substrates", "including", "C1333707#ent", "<e1>", ",", "the", "p85", "subunit", "PI3-kinase", ",", "and", "C2987154#ent", "<e2>"], "h": {"id": "C1333707", "name": "C1333707#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [20, 21]}}
{"token": ["C1565750#ent", "<e1>", "was", "eliminated", "primarily", "by", "renal", "excretion", "C1254351#ent", "<e2>", "biliary", "excretion", "an", "important", "pathway", "in", "rats", ",", "whereas", "metabolism", "was", "minimal", "in", "both", "species", "in", "vitro", "in", "vivo"], "h": {"id": "C1565750", "name": "C1565750#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}}
{"token": ["Truncation", "analysis", "that", "the", "C0950398#ent", "<e1>", "contained", "within", "the", "first", "200", "C3539946#ent", "<e2>", "Rep68/78", "."], "h": {"id": "C0950398", "name": "C0950398#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [11, 12]}}
{"token": ["This", "is", "the", "first", "report", "on", "an", "identification", "of", "the", "putative", "gene", "product", "adipocytes", "as", "C2604870#ent", "<e1>", "the", "expression", "of", "which", "is", "C1420295#ent", "<e2>", "regulated", "."], "h": {"id": "C2604870", "name": "C2604870#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [22, 23]}}
{"token": ["Amino", "acid", "analysis", "C0007075#ent", "<e1>", "FPA", "demonstrated", "the", "substitution", "of", "His", "for", "C1419345#ent", "<e2>", "at", "A", "alpha", "16", "."], "h": {"id": "C0007075", "name": "C0007075#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419345", "name": "C1419345#ent", "pos": [12, 13]}}
{"token": ["The", "A-kinase", "anchor", "protein", "13", "AKAP13", ",", "alias", "C1705580#ent", "<e1>", "and", "lbc", ")", "tethers", "C0010531#ent", "<e2>", "its", "subcellular", "environment", "catalyses", "Rho", "GTPases", "activity", "as", "a", "guanine", "nucleotide", "exchange", "factor"], "h": {"id": "C1705580", "name": "C1705580#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [14, 15]}}
{"token": ["Preimplantation", "parthenogenetic", "mouse", "embryos", "expressed", "mRNA", "for", "the", "IGF-II", "receptor", "not", "for", "either", "C1708416#ent", "<e1>", "ligand", "or", "the", "IGF-I", "receptor", "indicating", "that", "the", "latter", "C1417679#ent", "<e2>", "are", "not", "expressed", "when", "inherited", "maternally", "."], "h": {"id": "C1708416", "name": "C1708416#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["Serum", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "is", "highly", "elevated", "in", "patients", "with", "C0085404#ent", "<e1>", "C0015674#ent", "<e2>", ")", "and", "is", "well", "correlated", "with", "the", "clinical", "manifestations", "C0015674#ent", "<e2>", "."], "h": {"id": "C0085404", "name": "C0085404#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [15, 16]}}
{"token": ["This", "prolonged", "and", "slow", "phosphorylation", "of", "C1705633#ent", "<e1>", "MAPK", "was", "distinct", "from", "other", "C2364020#ent", "<e2>"], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2364020", "name": "C2364020#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "when", "haplotypes", "were", "constructed", "from", "multiple", "polymorphisms", "of", "the", "C1334332#ent", "<e1>", "and", "HL", "genes", ",", "no", "segregation", "the", "C1706445#ent", "<e2>", "phenotype", "could", "be", "observed", "in", "the", "14", "Finnish", "families", "."], "h": {"id": "C1334332", "name": "C1334332#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706445", "name": "C1706445#ent", "pos": [20, 21]}}
{"token": ["Sensitization", "of", "post-irradiation", "(", "delayed", ")", "photohemolysis", "(", "DPH", ")", "and", "\"", "during", "irradiation", "\"", "(", "continuous", ")", "photohemolysis", "(", "C0054757#ent", "<e1>", ")", "were", "investigated", "for", "C0063220#ent", "<e2>", "Photofrin", "."], "h": {"id": "C0054757", "name": "C0054757#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0063220", "name": "C0063220#ent", "pos": [26, 27]}}
{"token": ["Besides", "MAPK", ",", "C0243045#ent", "<e1>", "Cdk7", ")", "in", "the", "C1333356#ent", "<e2>", "complex", "has", "also", "been", "found", "to", "potentiate", "hERalpha", "transactivation", "in", "vitro", "Ser(118", ")", "phosphorylation", "."], "h": {"id": "C0243045", "name": "C0243045#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333356", "name": "C1333356#ent", "pos": [9, 10]}}
{"token": ["C0017347#ent", "<e1>", "genes", "regulate", "endometrial", "development", "response", "to", "C0038317#ent", "<e2>"], "h": {"id": "C0017347", "name": "C0017347#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [8, 9]}}
{"token": ["The", "polyclonal", "antibody", "recombinant", "human", "C0210108#ent", "<e1>", "displayed", "approximately", "20", "-", "30", "%", "cross-reactivity", "with", "C1709394#ent", "<e2>", ",", "but", "did", "not", "bind", "PDGF-BB", "or", "other", "growth", "factors", "cytokines", "known", "to", "be", "secreted", "by", "bone", "cells"], "h": {"id": "C0210108", "name": "C0210108#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1709394", "name": "C1709394#ent", "pos": [15, 16]}}
{"token": ["Butyrate", "transport", "significantly", "reduced", "in", "the", "presence", "of", "short", "chain", "fatty", "acids", "SCFA", ")", ",", "C0000975#ent", "<e1>", ",", "propionate", "and", "other", "C1420102#ent", "<e2>", "(", "pyruvate", "and", "L-lactate", ")", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420102", "name": "C1420102#ent", "pos": [21, 22]}}
{"token": ["The", "larvae", "used", "mainly", "C0030940#ent", "<e1>", "such", "as", "trypsin/chymotrypsin", ",", "and", "the", "adult", "insects", "only", "C0109710#ent", "<e2>", "their", "digestive", "process"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0109710", "name": "C0109710#ent", "pos": [15, 16]}}
{"token": ["In", "rabbits", "SAMG", "and", "C1865361#ent", "<e1>", "are", "formed", "together", "in", "nearly", "equal", "amounts", "in", "the", "C0023899#ent", "<e2>", "and", "at", "the", "ratio", "4", "1", "in", "the", "intestine", "."], "h": {"id": "C1865361", "name": "C1865361#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [15, 16]}}
{"token": ["In", "rats", ",", "on", "the", "other", "hand", ",", "SAMG", "is", "exclusively", "formed", "in", "the", "intestine", "and", "C1865361#ent", "<e1>", "in", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C1865361", "name": "C1865361#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [20, 21]}}
{"token": ["These", "enzymes", "represent", "a", "conserved", "class", "of", "the", "GHMP", "family", "of", "C0031727#ent", "<e1>", ",", "which", "includes", "galactokinase", ",", "homoserine", "kinase", "mevalonate", "kinase", "and", "C1418695#ent", "<e2>", "with", "homologues", "in", "plants", "and", "several", "eubacteria", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418695", "name": "C1418695#ent", "pos": [23, 24]}}
{"token": ["We", "studied", "the", "effect", "of", "C1415335#ent", "<e1>", "on", "spontaneous", "and", "LPS-stimulated", "C0812246#ent", "<e2>", "production", "by", "human", "peripheral", "blood", "mononuclear", "cells", "PBMCs", ")", "of", "normal", "volunteers"], "h": {"id": "C1415335", "name": "C1415335#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}}
{"token": ["C1415335#ent", "<e1>", "inhibited", "LPS", "stimulated", "C0812246#ent", "<e2>", "productions", "in", "PBMCs", "of", "all", "5", "ceramide", "responders", "both", "at", "protein", "and", "mRNA", "expression", "level", "."], "h": {"id": "C1415335", "name": "C1415335#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [5, 6]}}
{"token": ["These", "results", "suggest", "that", "expression", "of", "the", "AMPD1", "and", "AMPD3", "C1417679#ent", "<e1>", "may", "be", "coordinated", "in", "myocytes", "to", "effect", "production", "an", "C1416427#ent", "<e2>", "holoenzyme", "of", "varying", "subunit", "composition", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416427", "name": "C1416427#ent", "pos": [21, 22]}}
{"token": ["Highly", "significant", "statistical", "correlations", "P", "less", "than", "0.0001", ")", "were", "found", "between", "cholestasis", "and", "malnutrition", ",", "prothrombin", "time", "C1415181#ent", "<e1>", ",", "alkaline", "phosphatase", "bilirubin", ",", "Maddrey", "'s", "discriminant", "function", ",", "C0017905#ent", "<e2>", "albumin", ",", "and", "histologic", "severity", "score"], "h": {"id": "C1415181", "name": "C1415181#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017905", "name": "C0017905#ent", "pos": [30, 31]}}
{"token": ["Montreux", "'", "has", "C1823832#ent", "<e1>", "pigmentation", "in", "the", "tepals", "with", "many", "C0015230#ent", "<e2>", ",", "and", "'", "Connecticut", "King", "'", "has", "flowers", "with", "carotenoid", "pigmentation", "without", "C0015230#ent", "<e2>", "."], "h": {"id": "C1823832", "name": "C1823832#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [11, 12]}}
{"token": ["C0036690#ent", "<e1>", "should", "be", "differentiated", "from", "C0158945#ent", "<e2>", "adrenogenital", "syndrome", "mucoviscidosis", ",", "intestinal", "infections", "long", "duration", "and", "sepsis", "with", "the", "hemolytic", "syndrom", "hemolytic", "disease", "neonates", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0158945", "name": "C0158945#ent", "pos": [6, 7]}}
{"token": ["Hemojuvelin", "(", "C1415529#ent", "<e1>", ";", "also", "called", "C3810562#ent", "<e2>", "RGMC", ")", "is", "the", "third", "member", "of", "this", "family", ",", "and", "mutations", "in", "this", "gene", "result", "a", "form", "of", "juvenile", "hemochromatosis", "type", "2A", "."], "h": {"id": "C1415529", "name": "C1415529#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3810562", "name": "C3810562#ent", "pos": [7, 8]}}
{"token": ["Two", "patients", "with", "allergic", "alveolitis", "to", "mouldy", "hay", "antigens", "(", "C0015634#ent", "<e1>", "were", "shown", "to", "have", "malabsorption", "due", "to", "C0007570#ent", "<e2>"], "h": {"id": "C0015634", "name": "C0015634#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [19, 20]}}
{"token": ["Granulomatous", "lung", "diseases", "such", "as", "sarcoidosis", ",", "hypersensitivity", "pneumonitis", "Wegener's", "granulomatosis", "and", "chronic", "beryllium", "disease", "along", "with", "C0018203#ent", "<e1>", "known", "infectious", "etiologies", "such", "as", "C0041296#ent", "<e2>", ",", "are", "major", "causes", "of", "morbidity", "and", "mortality", "throughout", "the", "world", "."], "h": {"id": "C0018203", "name": "C0018203#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [24, 25]}}
{"token": ["Values", "of", "170", "nmol/g", "were", "found", "for", "HPC", "and", "C1425021#ent", "<e1>", "in", "the", "brain", ",", "whereas", "the", "C0169014#ent", "<e2>", "concentration", "was", "120", "nmol/g", "."], "h": {"id": "C1425021", "name": "C1425021#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0169014", "name": "C0169014#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "suggest", "that", "syndecan-1", "and", "beta1", "integrin", "signaling", "downstream", "of", "AG73", "regulate", "adhesion", "and", "C0919336#ent", "<e1>", "production", "by", "C1422342#ent", "<e2>", "and", "M1", "cells"], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1422342", "name": "C1422342#ent", "pos": [19, 20]}}
{"token": ["C1705969#ent", "<e1>", "is", "safe", "and", "useful", "for", "improving", "C0025218#ent", "<e2>", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025218", "name": "C0025218#ent", "pos": [8, 9]}}
{"token": ["Although", "single", "lung", "transplantation", "C0723177#ent", "<e1>", ")", "is", "used", "to", "treat", "end-stage", "C1412502#ent", "<e2>", ",", "its", "effects", "on", "flow", "limitation", "and", "dyspnea", "are", "not", "well", "established", "."], "h": {"id": "C0723177", "name": "C0723177#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412502", "name": "C1412502#ent", "pos": [12, 13]}}
{"token": ["During", "development", "trap100", "is", "expressed", "in", "a", "dynamic", "C1420295#ent", "<e1>", "expression", "pattern", "consistent", "with", "function", "in", "C1417023#ent", "<e2>", "and", "jaw", "cartilage", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417023", "name": "C1417023#ent", "pos": [16, 17]}}
{"token": ["14", "days", "after", "the", "globulin", "treatment", "C1332656#ent", "<e1>", "and", "B", "were", "declining", "rapidly", "while", "C3", "and", "C4283853#ent", "<e2>", "approached", "normal", "values", "36", "days", "after", "treatment", "."], "h": {"id": "C1332656", "name": "C1332656#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [16, 17]}}
{"token": ["Immune", "adherence", "receptors", "were", "specific", "for", "C4283853#ent", "<e1>", "or", "C3b", ",", "while", "C3d", "receptors", "specific", "for", "C1332656#ent", "<e2>", "but", "unreactive", "with", "C4283853#ent", "<e1>", "."], "h": {"id": "C1332656", "name": "C1332656#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [6, 7]}}
{"token": ["Disseminated", "intravascular", "coagulation", "C1420151#ent", "<e1>", ")", "is", "a", "rarely", "described", "finding", "in", "C0276653#ent", "<e2>", "IPA", ")", "with", "unclear", "impact", "on", "mortality", "."], "h": {"id": "C1420151", "name": "C1420151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0276653", "name": "C0276653#ent", "pos": [12, 13]}}
{"token": ["While", "the", "role", "of", "glycemic", "control", "in", "the", "development", "of", "C0042373#ent", "<e1>", "complication", "is", "well", "established", "its", "role", "in", "C0007820#ent", "<e2>", "in", "patients", "with", "DM1", "remains", "unclear", "with", "epidemiologic", "studies", "conflicting", "data", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [19, 20]}}
{"token": ["Reducing", "risk", "factors", "patients", "with", "C0042373#ent", "<e1>", "reduce", "the", "subsequent", "incidence", "of", "C0007820#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [12, 13]}}
{"token": ["C0019435#ent", "<e1>", "was", "effective", "against", "surface", "aerobes", "only", "slightly", "active", "against", "P", "C0001144#ent", "<e2>", "."], "h": {"id": "C0019435", "name": "C0019435#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0001144", "name": "C0001144#ent", "pos": [12, 13]}}
{"token": ["In", "an", "effort", "to", "further", "characterize", "IRF-4", "function", ",", "we", "identified", "a", "novel", "interaction", "between", "IRF-4", "and", "C1414626#ent", "<e1>", ",", "a", "59-kDa", "member", "of", "the", "immunophilin", "family", "C1418795#ent", "<e2>", "PPIase", ")", "."], "h": {"id": "C1414626", "name": "C1414626#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418795", "name": "C1418795#ent", "pos": [27, 28]}}
{"token": ["Contents", "of", "starch", "and", "soluble", "sugars", "in", "upper", "source", "leaves", "were", "similar", "in", "C1843919#ent", "<e1>", "underexpressors", "and", "FtTPT", "overexpressors", "compared", "to", "the", "C1883559#ent", "<e2>", "the", "end", "of", "the", "photoperiod", "."], "h": {"id": "C1843919", "name": "C1843919#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [22, 23]}}
{"token": ["We", "aimed", "to", "confirm", "whether", "C0772415#ent", "<e1>", "was", "effective", "in", "patients", "with", "or", "without", "concurrent", "vascular", "risk", "factors", "C1421446#ent", "<e2>", ")", ",", "as", "previously", "suggested", "."], "h": {"id": "C0772415", "name": "C0772415#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421446", "name": "C1421446#ent", "pos": [18, 19]}}
{"token": ["A", "point", "mutation", "in", "the", "cDNA", "of", "human", "intestinal", "C0028941#ent", "<e1>", "has", "been", "recently", "identified", "in", "phenotype", "II", "C0028941#ent", "<e1>"], "h": {"id": "C0028941", "name": "C0028941#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028941", "name": "C0028941#ent", "pos": [9, 10]}}
{"token": ["However", ",", "nucleolar", "accumulation", "C0541106#ent", "<e1>", "may", "not", "be", "necessary", "for", "its", "oncogenic", "action", "because", "an", "C1332080#ent", "<e2>", "expressed", "in", "a", "lymphoma", "carrying", "a", "variant", "(", "1;2", ")", "chromosomal", "translocation", "not", "accumulate", "in", "nucleoli", "."], "h": {"id": "C0541106", "name": "C0541106#ent", "pos": [4, 5]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1332080", "name": "C1332080#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "show", "that", "salicylate", "and", "C1533168#ent", "<e1>", ",", "another", "organic", "acid", "stimulate", "DNA", "binding", "C1415749#ent", "<e2>", "HSF", ")", "in", "vivo"], "h": {"id": "C1533168", "name": "C1533168#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415749", "name": "C1415749#ent", "pos": [15, 16]}}
{"token": ["The", "results", "of", "immunoblot", "assay", "that", "both", "bands", "corresponding", "to", "C0030956#ent", "<e1>", "and", "mature", "forms", "of", "C1705752#ent", "<e2>", "decreased", "with", "the", "galactose", "diet", "90", "and", "70", "%", ",", "respectively", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705752", "name": "C1705752#ent", "pos": [16, 17]}}
{"token": ["Rats", "treated", "with", "high", "3mg/kg", "dose", "of", "C0004609#ent", "<e1>", "did", "not", "express", "nicotine-induced", "C0047123#ent", "<e2>", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0047123", "name": "C0047123#ent", "pos": [13, 14]}}
{"token": ["Cibacron", "blue", "3GA", "reactive", "blue", "2", "well", "as", "C0038880#ent", "<e1>", "also", "reduced", "pressor", "responses", "to", "C1850106#ent", "<e2>", "(", "maximally", "by", "50", "to", "70", "%", ")", "."], "h": {"id": "C0038880", "name": "C0038880#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1850106", "name": "C1850106#ent", "pos": [15, 16]}}
{"token": ["C1414306#ent", "<e1>", "C3815928#ent", "<e2>", ")", "are", "the", "largest", "known", "subfamily", "of", "C3815928#ent", "<e2>", ",", "comprising", "at", "least", "a", "dozen", "members", "."], "h": {"id": "C1414306", "name": "C1414306#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3815928", "name": "C3815928#ent", "pos": [2, 3]}}
{"token": ["These", "results", "are", "correlated", "with", "C0242634#ent", "<e1>", "etiology", ",", "fistula", "output", ",", "fistula", "location", ",", "type", "of", "treatment", "C0162429#ent", "<e2>", ",", "electrolyte", "disturbances", "sepsis", "."], "h": {"id": "C0242634", "name": "C0242634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [18, 19]}}
{"token": ["The", "C1367595#ent", "<e1>", "(", "also", "called", "C3811249#ent", "<e2>", ")", "gene", "was", "selected", "as", "a", "candidate", "because", "of", "its", "homology", "to", "EXT1", "and", "EXT2", ",", "putative", "tumor", "suppressor", "genes"], "h": {"id": "C1367595", "name": "C1367595#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3811249", "name": "C3811249#ent", "pos": [6, 7]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "classic", "late-infantile", "neuronal", "ceroid-lipofuscinosis", "C1540042#ent", "<e2>", ",", "and", "for", "adult", "neuronal", "ceroid-lipofuscinosis", "CLN4", ",", "have", "not", "been", "located", ",", "the", "former", "having", "been", "excluded", "from", "chromosomes", "1", "16", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1540042", "name": "C1540042#ent", "pos": [8, 9]}}
{"token": ["The", "C1417679#ent", "<e1>", "CLN1", "and", "CLN2", "encode", "lysosomal", "palmitoyl", "protein", "thioesterase", "C1540042#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1540042", "name": "C1540042#ent", "pos": [11, 12]}}
{"token": ["The", "present", "study", "did", "not", "indicate", "any", "linkage", "between", "CNCL", "and", "the", "canine", "CLN3", "homologue", "or", "to", "homologues", "of", "markers", "for", "C1417679#ent", "<e1>", "that", "map", "close", "to", "human", "C1540042#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1540042", "name": "C1540042#ent", "pos": [28, 29]}}
{"token": ["An", "antagonist", "of", "C0018358#ent", "<e1>", "1H[1,2,4]oxadiazole[4,3]quinoxalin-1-one", "(", "ODQ", ")", ",", "inhibited", "the", "C1414864#ent", "<e2>", "relaxation", "produced", "by", "ONOO-", "."], "h": {"id": "C0018358", "name": "C0018358#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414864", "name": "C1414864#ent", "pos": [12, 13]}}
{"token": ["C1706546#ent", "<e1>", "markedly", "increased", "C0017346#ent", "<e2>", ",", "protein", ",", "RNA", ",", "and", "DNA", "synthesis", "cell", "division", "the", "cultured", "cartilage", "cells"], "h": {"id": "C1706546", "name": "C1706546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [4, 5]}}
{"token": ["Bovine", "granulosa", "cells", "thrombin", "receptor", "C1705939#ent", "<e1>", ")", "mRNA", ",", "and", "as", "seen", "with", "prothrombin", "mRNA", "and", "C0061495#ent", "<e2>", "mRNA", ",", "cells", "isolated", "from", "small", "follicles", "more", "C1705939#ent", "<e1>", "mRNA", "than", "cells", "from", "large", "follicles", "."], "h": {"id": "C0061495", "name": "C0061495#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705939", "name": "C1705939#ent", "pos": [5, 6]}}
{"token": ["To", "compare", "the", "abilities", "of", "the", "plb1", "null", "mutant", "the", "revertant", "and", "the", "isogenic", "parent", "to", "cross", "the", "gastrointestinal", "(GI)", "tract", "cause", "C0243026#ent", "<e1>", "an", "oral-intragastric", "infant", "mouse", "model", "C0006849#ent", "<e2>", "was", "used", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [29, 30]}}
{"token": ["Patient", "A", "stomatitis", ",", "skin", "infections", "and", "C0243026#ent", "<e1>", ";", "patient", "B", "respiratory", "infections", "periodontitis", ",", "and", "C0006849#ent", "<e2>"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [17, 18]}}
{"token": ["The", "phenotyping", "procedure", "done", "according", "to", "Price", "Evans", "'", "method", "using", "the", "C0796518#ent", "<e1>", "specific", "probe", "C1254351#ent", "<e2>", "--", "sulphadimidine", "."], "h": {"id": "C0796518", "name": "C0796518#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}}
{"token": ["One", "C0051169#ent", "<e1>", "catalyzed", "the", "14", "alpha-demethylation", "of", "lanosterol", "and", "bound", "C0072177#ent", "<e2>", "with", "an", "equimolar", "ratio", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072177", "name": "C0072177#ent", "pos": [11, 12]}}
{"token": ["Since", "30", "degrees", "C1412430#ent", "<e1>", "camera", "position", "the", "best", "visualization", "of", "the", "anterior", "and", "posterior", "wall", "C1419906#ent", "<e2>", "is", "superior", "to", "qERNV", "in", "the", "evaluation", "of", "posterior", "wall", "asynergies", "."], "h": {"id": "C1412430", "name": "C1412430#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419906", "name": "C1419906#ent", "pos": [16, 17]}}
{"token": ["C3669212#ent", "<e1>", "correlated", "significantly", "with", "plasma", "C3538795#ent", "<e2>", "concentration", ",", "WBC", "count", "ALP", "activity", ",", "plasma", "concentrations", "of", "urea", "nitrogen", "creatinine", ",", "sodium", ",", "potassium", ",", "and", "chloride", ",", "right", "ventricular", "endodiastolic", "pressure", "right", "atrial", "pressure"], "h": {"id": "C3669212", "name": "C3669212#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538795", "name": "C3538795#ent", "pos": [6, 7]}}
{"token": ["The", "effects", "of", "C0020538#ent", "<e1>", "its", "treatment", "by", "a", "converting", "enzyme", "inhibitor", "C0136123#ent", "<e2>", ")", "on", "the", "structure", "and", "function", "of", "large", "arteries", "were", "studied", "in", "the", "Goldblatt", "1", "clip--2", "kidney", "rat", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0136123", "name": "C0136123#ent", "pos": [12, 13]}}
{"token": ["C0016424#ent", "<e1>", "and", "LH", "in", "C0001002#ent", "<e2>", "precipitates", "of", "timed", "overnight", "urine", "collections", "measured", "by", "radioimmunoassay", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [5, 6]}}
{"token": ["We", "extended", "the", "search", "for", "mutations", "to", "the", "C1333336#ent", "<e1>", "C0079429#ent", "<e2>", "and", "showed", "that", "mutations", "in", "C1333336#ent", "<e1>", "also", "cause", "this", "disorder", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333336", "name": "C1333336#ent", "pos": [8, 9]}}
{"token": ["All", "three", "HERKO", "lines", "expressed", "high", "amounts", "C4084746#ent", "<e1>", "osteopontin", ",", "osteonectin", ",", "fibronectin", ",", "C0057252#ent", "<e2>", ",", "biglycan", ",", "and", "alkaline", "phosphatase"], "h": {"id": "C4084746", "name": "C4084746#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0057252", "name": "C0057252#ent", "pos": [15, 16]}}
{"token": ["The", "stimulatory", "effect", "of", "C0917964#ent", "<e1>", "(", "1", "mumol/l", ")", "could", "be", "inhibited", "by", "C1367551#ent", "<e2>", "(", "0.1", "unit/ml", ")", ",", "but", "was", "insensitive", "to", "indomethacin", "(", "1", "mumol/l", ")", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367551", "name": "C1367551#ent", "pos": [14, 15]}}
{"token": ["These", "results", "provide", "further", "evidence", "that", "calcitonin-induced", "inhibition", "of", "osteoclast", "function", "mediated", "by", "elevation", "of", "cAMP", "levels", "and", "suggest", "that", "C0917964#ent", "<e1>", "could", "be", "used", "to", "augment", "the", "therapeutic", "effects", "C1367551#ent", "<e2>", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1367551", "name": "C1367551#ent", "pos": [30, 31]}}
{"token": ["Adenosine", "triphosphate-dependent", "quenching", "of", "the", "fluorescence", "of", "the", "weak", "base", "C0034403#ent", "<e1>", "by", "everted", "membrane", "vesicles", "that", "the", "C1417500#ent", "<e2>", "+", "-ATPase", "is", "a", "proton", "pump", "of", "generating", "an", "electrochemical", "proton", "gradient", "."], "h": {"id": "C0034403", "name": "C0034403#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [18, 19]}}
{"token": ["ISC", "response", "by", "PB-MNC", "following", "stimulation", "with", "C1854580#ent", "<e1>", "exhibited", "a", "reciprocal", "relationship", "to", "TRAb", "in", "patients", "with", "C0339143#ent", "<e2>"], "h": {"id": "C1854580", "name": "C1854580#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [18, 19]}}
{"token": ["ISC", "response", "by", "PB-MNC", "following", "stimulation", "with", "C1854580#ent", "<e1>", "was", "significantly", "decreased", "in", "patients", "in", "the", "hyperthyroid", "state", "C0339143#ent", "<e2>", "Hashimoto's", "thyroiditis", "compared", "with", "that", "of", "normal", "controls"], "h": {"id": "C1854580", "name": "C1854580#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [18, 19]}}
{"token": ["Using", "purified", "B", "cells", "some", "spontaneous", "ISC", "response", "without", "C1854580#ent", "<e1>", "stimulation", "was", "observed", "in", "patients", "in", "the", "hyperthyroid", "state", "C0339143#ent", "<e2>", "Hashimoto's", "thyroiditis"], "h": {"id": "C1854580", "name": "C1854580#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "thapsigargin", ",", "an", "inhibitor", "of", "sarco(endo)plasmic", "reticulum", "Ca(2", "+", ")", "C1706373#ent", "<e1>", ",", "remarkably", "decreased", "stretch-induced", "IGF-I", "secretion", "from", "C1824728#ent", "<e2>", "."], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1824728", "name": "C1824728#ent", "pos": [22, 23]}}
{"token": ["The", "reaction", "proceeds", "faster", "in", "a", "polar", "solvent", "as", "C0012403#ent", "<e1>", "probably", "because", "of", "stabilization", "of", "the", "electronically", "polarized", "C1420620#ent", "<e2>", "structure", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420620", "name": "C1420620#ent", "pos": [19, 20]}}
{"token": ["Thereafter", ",", "if", "there", "was", "no", "contraindication", ",", "patients", "with", "infarction", "and/or", "C0002962#ent", "<e1>", "continued", "on", "C0025859#ent", "<e2>", "for", "2", "years", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [16, 17]}}
{"token": ["The", "Km", "for", "C0134796#ent", "<e1>", "0.14", "and", "4.44", "mm", "for", "APase", "I", "and", "C3273406#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0134796", "name": "C0134796#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [13, 14]}}
{"token": ["The", "rigorously", "investigated", "drugs", "reported", "to", "reduce", "vertebral", "fractures", "the", "C0012544#ent", "<e1>", "risedronate", ",", "the", "selective", "oestrogen-receptor", "modulator", "raloxifene", ",", "the", "C1258800#ent", "<e2>", "parathyroid", "hormone", ",", "most", "recently", ",", "strontium", "ranelate", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1258800", "name": "C1258800#ent", "pos": [21, 22]}}
{"token": ["Previous", "studies", "have", "indicated", "that", "C0012544#ent", "<e1>", "pretreatment", "can", "inhibit", "the", "C1258800#ent", "<e2>", "actions", "of", "PTH", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1258800", "name": "C1258800#ent", "pos": [11, 12]}}
{"token": ["C0245514#ent", "<e1>", "did", "not", "affect", "the", "angiotensin", "II-induced", "activation", "of", "C0010536#ent", "<e2>", "or", "its", "downstream", "signaling", "kinases", "extracellular", "signal-regulated", "kinase", "1/2", "the", "cytosol", "."], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [10, 11]}}
{"token": ["This", "enzyme", "has", "a", "high", "degree", "of", "sequence", "identity", "with", "other", "cholinesterases", ",", "C0054741#ent", "<e1>", "esterase-6", ",", "lysophospholipase", ",", "and", "C1420709#ent", "<e2>", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [20, 21]}}
{"token": ["C1412379#ent", "<e1>", "C3539529#ent", "<e2>", ")", "catalyzes", "the", "formation", "of", "decarboxylated", "C3539529#ent", "<e2>", ",", "a", "precursor", "of", "the", "polyamines", "spermidine", "and", "spermine", "."], "h": {"id": "C1412379", "name": "C1412379#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539529", "name": "C3539529#ent", "pos": [2, 3]}}
{"token": ["The", "gene", "for", "C1412379#ent", "<e1>", "C3539529#ent", "<e2>", ")", "was", "isolated", "from", "a", "rat", "genomic", "library", "C3539529#ent", "<e2>", "cDNA", "as", "a", "probe", "."], "h": {"id": "C1412379", "name": "C1412379#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539529", "name": "C3539529#ent", "pos": [5, 6]}}
{"token": ["To", "identify", "the", "promoter", "element(s", ")", "required", "for", "increased", "gene", "transcription", "acute", "condition", "529", "bp", "5'-flanking", "region", "C4283942#ent", "<e1>", "fused", "to", "the", "C0008169#ent", "<e2>", "CAT", ")", "reporter", "gene", "introduced", "into", "BNL", "liver", "cells"], "h": {"id": "C4283942", "name": "C4283942#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0008169", "name": "C0008169#ent", "pos": [22, 23]}}
{"token": ["To", "study", "the", "dynamic", "changes", "of", "serum", "pro-inflammatory", "cytokines", "and", "anti-inflammatory", "cytokines", "patients", "with", "C0149512#ent", "<e1>", "to", "explore", "the", "effect", "of", "912", "compound", ",", "a", "C1134558#ent", "<e2>", "preparation", "for", "intervention", "."], "h": {"id": "C0149512", "name": "C0149512#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1134558", "name": "C1134558#ent", "pos": [25, 26]}}
{"token": ["Bivalirudin", "appears", "to", "have", "a", "wider", "therapeutic", "window", "C1451270#ent", "<e1>", ",", "possibly", "because", "C0168273#ent", "<e2>", "only", "transiently", "inhibits", "the", "active", "site", "thrombin", "."], "h": {"id": "C1451270", "name": "C1451270#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0168273", "name": "C0168273#ent", "pos": [13, 14]}}
{"token": ["It", "is", "now", "known", "that", "the", "GM-CSF", "belongs", "to", "a", "new", "family", "of", "C1334117#ent", "<e1>", "are", "characterized", "by", "a", "relatively", "short", "intracytoplasmic", "domain", "lacks", "a", "C1421249#ent", "<e2>"], "h": {"id": "C1334117", "name": "C1334117#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [25, 26]}}
{"token": ["Twenty-nine", "women", "with", "C0029458#ent", "<e1>", "treated", "with", "estrogen", "(", "HRT", ")", "or", "C0244404#ent", "<e2>", "for", "12", "months", "."], "h": {"id": "C0029458", "name": "C0029458#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0244404", "name": "C0244404#ent", "pos": [12, 13]}}
{"token": ["We", "have", "previously", "reported", "that", "Fas-resistant", "A20", "cells", "(", "C1707081#ent", "<e1>", ")", "have", "phospholipase", "D", "PLD", ")", "activity", "upregulated", "by", "endogenous", "C1418642#ent", "<e2>", "overexpression", "."], "h": {"id": "C1707081", "name": "C1707081#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418642", "name": "C1418642#ent", "pos": [21, 22]}}
{"token": ["Hematopoietic", "cytokines", "growth", "factors", "and", "stimulated", "lymphocyte", "antigen", "receptors", "activate", "specific", "MAPKs", "by", "C2712370#ent", "<e1>", "the", "balance", "of", "C1452441#ent", "<e2>", "the", "protein", "phosphatases", "target", "their", "activation", "sites"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1452441", "name": "C1452441#ent", "pos": [18, 19]}}
{"token": ["Previous", "results", "have", "shown", "that", "the", "Spt3", "and", "Spt8", "components", "of", "C1335804#ent", "<e1>", "regulate", "initiation", "of", "transcription", "of", "particular", "C0017337#ent", "<e2>", "by", "controlling", "the", "level", "of", "TATA-binding", "protein", "TBP/Spt15", ")", "associated", "with", "TATA", "box"], "h": {"id": "C1335804", "name": "C1335804#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "depletion", "of", "TAF17", ",", "which", "is", "also", "present", "in", "the", "C1335804#ent", "<e1>", "histone", "acetylase", "complex", "causes", "a", "decrease", "in", "transcription", "of", "most", "C0017337#ent", "<e2>", "."], "h": {"id": "C1335804", "name": "C1335804#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [25, 26]}}
{"token": ["We", "report", "here", "that", "heat", "shock", "protein", "32", "C1415619#ent", "<e1>", ")", ",", "also", "known", "as", "heme", "oxygenase-1", "C1415619#ent", "<e1>", ")", ",", "is", "a", "novel", "KIT-inducible", "survival", "factor", "in", "neoplastic", "MCs", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [8, 9]}}
{"token": ["Apolipoprotein", "E", "apoE", ")", "and", "apoE-derived", "proteolytic", "fragments", "present", "in", "amyloid", "deposits", "C2931257#ent", "<e1>", "AD", ")", "and", "cerebral", "amyloid", "angiopathy", "C1704466#ent", "<e2>", ")", "."], "h": {"id": "C2931257", "name": "C2931257#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704466", "name": "C1704466#ent", "pos": [20, 21]}}
{"token": ["In", "group", "II", "molecular", "activity", "the", "C0007804#ent", "<e1>", "twofold", "to", "threefold", "lower", "and", "that", "of", "C1412554#ent", "<e2>", "of", "normal", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412554", "name": "C1412554#ent", "pos": [15, 16]}}
{"token": ["MSD", "cell", "lines", "displayed", "deficiencies", "of", "C0007804#ent", "<e1>", "iduronate", "sulfatase", "but", "activities", "of", "C1412554#ent", "<e2>", "N-acetylgalactosamine", "6-sulfate", "sulfatase", "N-acetylglucosamine", "6-sulfate", "sulfatase", "within", "normal", "ranges", "but", "not", "consistently", "."], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412554", "name": "C1412554#ent", "pos": [13, 14]}}
{"token": ["These", "proteins", "were", "identified", "as", "L5", ",", "L6", ",", "L10", ",", "C1825519#ent", "<e1>", ",", "and", ",", "in", "lower", "yield", ",", "L9", ",", "C1419631#ent", "<e2>", ",", "and", "L17", "."], "h": {"id": "C1825519", "name": "C1825519#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419631", "name": "C1419631#ent", "pos": [22, 23]}}
{"token": ["Post-infusion", "C1419788#ent", "<e1>", "increased", "in", "C0036193#ent", "<e2>", "responsive", "patients", ",", "the", "change", "in", "C1419788#ent", "<e1>", "being", "correlated", "(", "r", "=", "0.82", ")", "with", "the", "pre-infusion", "C1419788#ent", "<e1>", "."], "h": {"id": "C1419788", "name": "C1419788#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036193", "name": "C0036193#ent", "pos": [5, 6]}}
{"token": ["We", "previously", "reported", "that", "there", "were", "three", "copies", "of", "C3272383#ent", "<e1>", "coding", "for", "F1-alpha", "and", "two", "copies", "of", "C3811062#ent", "<e2>", "coding", "for", "F1-gamma", "on", "the", "left", "and", "right", "arm", "of", "chromosome", "II", "respectively", "."], "h": {"id": "C3272383", "name": "C3272383#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811062", "name": "C3811062#ent", "pos": [18, 19]}}
{"token": ["The", "involvement", "of", "the", "intestinal", "mucosa", "of", "the", "gut-associated", "lymphoid", "tissue", "C0012754#ent", "<e1>", "studied", "in", "six", "severely", "C0277565#ent", "<e2>", "harbour", "seals", "11", "to", "16", "days", "after", "experimental", "infection"], "h": {"id": "C0012754", "name": "C0012754#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [17, 18]}}
{"token": ["The", "novel", "C2936517#ent", "<e1>", "WAY", "100,135", ",", "MDL", "73005", "C0059037#ent", "<e2>", "and", "(", "very", "potently", ")", "SDZ", "216", "-", "525", "all", "blocked", "DIH", "."], "h": {"id": "C2936517", "name": "C2936517#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [9, 10]}}
{"token": ["Because", "C3537368#ent", "<e1>", "is", "required", "to", "C1332924#ent", "<e2>", "the", "assembly", "of", "a", "functional", "myosin", "II", "motor", "we", "examined", "the", "expression", "of", "the", "general", "cell", "GC", ")", "C3537368#ent", "<e1>", "isoform", "in", "ovarian", "tumors"], "h": {"id": "C3537368", "name": "C3537368#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332924", "name": "C1332924#ent", "pos": [6, 7]}}
{"token": ["Caenorhabditis", "elegans", "C3537368#ent", "<e1>", "facilitates", "this", "by", "functioning", "both", "as", "a", "C1332924#ent", "<e2>", "and", "as", "a", "Hsp90", "cochaperone", "myosin", "during", "thick", "filament", "assembly", "."], "h": {"id": "C3537368", "name": "C3537368#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332924", "name": "C1332924#ent", "pos": [11, 12]}}
{"token": ["C0595398#ent", "<e1>", "is", "therefore", "both", "highly", "effective", "in", "maintaining", "remission", "in", "C0009324#ent", "<e2>", "well", "tolerated", "in", "both", "conventional", "and", "high", "dosage", "the", "latter", "equivalent", "to", "5.5", "g/day", "of", "sulphasalazine", ")", "."], "h": {"id": "C0595398", "name": "C0595398#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [11, 12]}}
{"token": ["RAAS", "activity", "decreased", "during", "C0018802#ent", "<e1>", "treatment", "with", "angiotension-converting", "enzyme", "inhibitors", "captopril", ",", "C0072973#ent", "<e2>", ",", "prestarium", ")", "and", "an", "angiotensin", "II-receptor", "blocker", "cosaar", ")", ",", "which", "is", "indicative", "of", "the", "efficiency", "of", "C0018802#ent", "<e1>", "treatment", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0072973", "name": "C0072973#ent", "pos": [13, 14]}}
{"token": ["We", "specifically", "examine", "their", "roles", "in", "the", "treatment", "of", "C0009663#ent", "<e1>", "and", "verruca", ",", "hemangiomas", ",", "keloids", ",", "skin", "cancers", "C0013595#ent", "<e2>", "psoriasis", ",", "Behcet", "disease", "chronic", "granulomatous", "disease", "wound", "healing", "and", "cutaneous", "T", "cell", "lymphoma"], "h": {"id": "C0009663", "name": "C0009663#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [20, 21]}}
{"token": ["However", ",", "since", "neither", "Sheehan's", "syndrome", "painless", "thyroiditis", "a", "rare", "C0014130#ent", "<e1>", "the", "thyroid", "function", "patients", "with", "postpartum", "hypopituitarism", "previously", "diagnosed", "C0677607#ent", "<e2>", "be", "carefully", "evaluated", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [21, 22]}}
{"token": ["C0053355#ent", "<e1>", "enhanced", "the", "antitumor", "action", "the", "antitumor", "antibiotics", "bleomycin", "and", "C0014582#ent", "<e2>", "."], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [11, 12]}}
{"token": ["C0053355#ent", "<e1>", "also", "increases", "the", "effects", "of", "antitumor", "agents", "as", "C0014582#ent", "<e2>", ",", "and", "bleomycin", "."], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [10, 11]}}
{"token": ["From", "these", "observations", ",", "we", "concluded", ":", "Intracellular", "C1333909#ent", "<e1>", "+", "is", "essential", "for", "GTP", "to", "activate", "the", "C1427594#ent", "<e2>"], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1427594", "name": "C1427594#ent", "pos": [18, 19]}}
{"token": ["However", ",", "retained", "C1705791#ent", "<e1>", "activation", "under", "conditions", "in", "which", "C1425569#ent", "<e2>", "and", "Mek", "activation", "is", "lost", "is", "observed", ",", "suggesting", "that", "G(1)/S", "arrest", "acts", "at", "the", "level", "of", "C1705791#ent", "<e1>", "dephosphorylation", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [10, 11]}}
{"token": ["Although", "bilateral", "refractive", "amblyopia", "account", "for", "1", "to", "2", "%", "of", "all", "C0152190#ent", "<e1>", "there", "is", "little", "consistent", "information", "in", "the", "literature", "regarding", "C0002418#ent", "<e2>", "from", "bilateral", "hyperopia"], "h": {"id": "C0152190", "name": "C0152190#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002418", "name": "C0002418#ent", "pos": [23, 24]}}
{"token": ["Our", "results", "indicate", "that", "PAF", "and", "TNF-alpha", "could", "be", "implicated", "in", "the", "pathogenesis", "of", "C0027726#ent", "<e1>", "through", "the", "inhibition", "of", "C1418888#ent", "<e2>", "synthesis", "by", "glomerular", "epithelial", "cells"], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [20, 21]}}
{"token": ["We", "examined", "C0054120#ent", "<e1>", "pharmacokinetics", "in", "nine", "patients", "with", "C0023890#ent", "<e2>", "in", "six", "healthy", "subjects"], "h": {"id": "C0054120", "name": "C0054120#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [9, 10]}}
{"token": ["We", "report", "details", "of", "two", "patients", "who", "had", "C0030491#ent", "<e1>", "a", "transient", "phenomenon", "following", "C1290884#ent", "<e2>"], "h": {"id": "C0030491", "name": "C0030491#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "immune", "function", "changes", "in", "T", "cell", "populations", "over", "a", "1-year", "period", "in", "a", "series", "of", "progressive", "C0026769#ent", "<e1>", "MS", ")", "patients", "treated", "with", "regimens", "of", "C0010583#ent", "<e2>", "as", "part", "of", "the", "Northeast", "Multiple", "Sclerosis", "Treatment", "Group"], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [27, 28]}}
{"token": ["The", "promoter", "P97", "of", "human", "papillomavirus-16", "(", "HPV-16", ")", "gives", "rise", "to", "transcripts", "that", "encode", "the", "C0029016#ent", "<e1>", "the", "virus", ",", "C0133938#ent", "<e2>", "and", "E7", "."], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0133938", "name": "C0133938#ent", "pos": [21, 22]}}
{"token": ["The", "localization", "and", "activity", "of", "ATPase", ",", "IDPase", ",", "C0031607#ent", "<e1>", "alkaline", "phosphatase", "well", "as", "of", "the", "oxidoreductases", "(", "cytochrome", "oxidase", "C0038615#ent", "<e2>", "NADH-dehydrogenase", ")", "were", "studied", "."], "h": {"id": "C0031607", "name": "C0031607#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038615", "name": "C0038615#ent", "pos": [21, 22]}}
{"token": ["The", "effects", "of", "2,6-dimethyl-4-(2-nitrophenyl)-5-(2-oxo-1,3,2-dioxaphosphorinan-2-", "yl)-1,4-", "dihydropyridine", "3-carboxylate", "(", "C0057636#ent", "<e1>", ")", ",", "a", "new", "dihydropyridine", "calcium", "antagonist", "on", "C1412137#ent", "<e2>", "cardiac", "muscles", "[3H]-nitrendipine", "binding", "to", "the", "cardiac", "muscle", "brain", "membranes", "investigated", "in", "vitro"], "h": {"id": "C0057636", "name": "C0057636#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [18, 19]}}
{"token": ["Cytotoxicity", "of", "C1098860#ent", "<e1>", "was", "inhibited", "by", "phosphoramidon", ",", "a", "known", "inhibitor", "of", "C0025250#ent", "<e2>", "enzymatic", "activity"], "h": {"id": "C1098860", "name": "C1098860#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [13, 14]}}
{"token": ["Promastigotes", "of", "multiple", "Leishmania", "species", "rapidly", "degrade", "C1367472#ent", "<e1>", "by", "using", "surface-localized", "and", "secreted", "metalloprotease", "C0061676#ent", "<e2>", ")", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061676", "name": "C0061676#ent", "pos": [15, 16]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "report", "the", "prevalence", "of", "C0524620#ent", "<e1>", "HIV-infected", "patients", "and", "compare", "insulin", "resistance", "total", "body", "C0030196#ent", "<e2>", ",", "and", "visceral", "fat", "adipokines", "in", "those", "with", "and", "without", "C0524620#ent", "<e1>"], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [21, 22]}}
{"token": ["Acute", "arterial", "occlusions", "the", "extremities", "may", "result", ",", "in", "approximately", "7.5", "%", "of", "cases", ",", "in", "a", "severe", "and", "complex", "C0524620#ent", "<e1>", "often", "leads", "to", "loss", "of", "C0030196#ent", "<e2>", "and", "life", "."], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [27, 28]}}
{"token": ["In", "vitro", "with", "human", "liver", "microsomes", "have", "suggested", "that", "major", "oxidation", "pathways", "C0025887#ent", "<e1>", "are", "predominantly", "catalyzed", "by", "the", "genetically", "determined", "C3887685#ent", "<e2>", "cytochrome", "P450IID6)", "."], "h": {"id": "C0025887", "name": "C0025887#ent", "pos": [12, 13]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [21, 22]}}
{"token": ["C0025887#ent", "<e1>", "has", "been", "reported", "to", "be", "hydroxylated", "by", "C3887685#ent", "<e2>", "CYP2D6", ")", "in", "humans", "."], "h": {"id": "C0025887", "name": "C0025887#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [9, 10]}}
{"token": ["EMs", ",", "but", "not", "PMs", ",", "are", "susceptible", "to", "drug", "interactions", "C0025887#ent", "<e1>", "and", "drugs", "that", "inhibit", "C3887685#ent", "<e2>", "(", "e.g.", "quinidine", ")", "."], "h": {"id": "C0025887", "name": "C0025887#ent", "pos": [11, 12]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [17, 18]}}
{"token": ["In", "general", ",", "most", "sites", "of", "SDZ", "214", "-", "103", "C0023689#ent", "<e1>", "appear", "to", "be", "more", "specific", "than", "those", "of", "C0010592#ent", "<e2>"], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [20, 21]}}
{"token": ["C0023689#ent", "<e1>", "a", "high", "molecular", "weight", "in", "the", "same", "range", "as", "C0010592#ent", "<e2>", "and", "also", "does", "not", "appear", "to", "be", "glycosylated", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}}
{"token": ["Carbohydrate", "analyses", "the", "purified", "C1174250#ent", "<e1>", "that", "it", "was", "not", "a", "C0072522#ent", "<e2>", ",", "a", "characteristic", "that", "distinguishes", "it", "from", "porcine", "and", "rat", "renal", "dipeptidase"], "h": {"id": "C1174250", "name": "C1174250#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [11, 12]}}
{"token": ["However", ",", "C0034931#ent", "<e1>", "slightly", "but", "significantly", "increased", "the", "C0242287#ent", "<e2>", "content", "(", "m", ")", "of", "e.p.ps", "."], "h": {"id": "C0034931", "name": "C0034931#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242287", "name": "C0242287#ent", "pos": [9, 10]}}
{"token": ["However", ",", "C0030196#ent", "<e1>", "in", "cases", "with", "C0037928#ent", "<e2>", "not", "predetermine", "an", "unsuccessful", "prophylaxis", ",", "2/14", "(", "14", "percent", ")", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037928", "name": "C0037928#ent", "pos": [7, 8]}}
{"token": ["A", "monoclonal", "antibody", "CYP2B6", "and", "the", "CYP3A", "inhibitor", "ketoconazole", "substantially", "inhibited", "R-138727", "formation", ",", "whereas", "inhibitors", "of", "C1828473#ent", "<e1>", "(", "sulfaphenazole", ")", "and", "CYP2C19", "(", "C0028978#ent", "<e2>", ")", "did", "not", "."], "h": {"id": "C1828473", "name": "C1828473#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [25, 26]}}
{"token": ["To", "determine", "the", "effectiveness", "of", "enterocin", "AS-48", "on", "C1318973#ent", "<e1>", "in", "combination", "with", "chemical", "preservatives", "C0815040#ent", "<e2>", "and", "neutral", "pH."], "h": {"id": "C1318973", "name": "C1318973#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [15, 16]}}
{"token": ["Herein", "we", "examined", "the", "signaling", "downstream", "of", "insulin", "receptor", "activation", ",", "focusing", "upon", "the", "role", "of", "1-phosphatidylinositol", "3-kinase", "the", "C0072402#ent", "<e1>", "also", "known", "as", "C0164786#ent", "<e2>", "in", "the", "internalization", "of", "beta(2)-adrenergic", "receptors"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [19, 20]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [24, 25]}}
{"token": ["The", "efficacy", "and", "tolerance", "of", "C0006938#ent", "<e1>", "was", "prospectively", "studied", "as", "monotherapy", "for", "C0235222#ent", "<e2>", "BH", ")", ",", "as", "well", "as", "combined", "modality", "with", "thiazides", "diuretic", "nifedipine", "as", "a", "third", "drug"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235222", "name": "C0235222#ent", "pos": [13, 14]}}
{"token": ["Synergy", "was", "observed", "when", "rifampin", "was", "combined", "with", "miconazole", "and", "C0086620#ent", "<e1>", "was", "not", "observed", "when", "rifampin", "was", "combined", "with", "C0022625#ent", "<e2>", "."], "h": {"id": "C0086620", "name": "C0086620#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [20, 21]}}
{"token": ["A", "per-protocol", "analysis", "of", "332", "patients", "demonstrated", "that", "C0086620#ent", "<e1>", "not", "statistically", "significantly", "inferior", "to", "C0022625#ent", "<e2>", "treatment", "."], "h": {"id": "C0086620", "name": "C0086620#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [15, 16]}}
{"token": ["When", "deregulated", ",", "C1334077#ent", "<e1>", "inactivates", "the", "tumor", "suppressor", "proteins", "retinoblastoma", "C2984536#ent", "<e2>", ",", "and", "p130", "."], "h": {"id": "C1334077", "name": "C1334077#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2984536", "name": "C2984536#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "these", "mutations", "render", "S37A", "C1332803#ent", "<e1>", "susceptible", "to", "proteasomal", "degradation", "response", "to", "activation", "of", "C1335238#ent", "<e2>", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [16, 17]}}
{"token": ["Several", "investigators", "reported", "that", "individuals", "with", "C0011849#ent", "<e1>", "and", "women", "on", "hemodialysis", "treated", "with", "recombinant", "erythropoietin", "C1414438#ent", "<e2>", ")", "attained", "lower", "hematocrits", "than", "individuals", "without", "C0011849#ent", "<e1>", "and", "men", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [6, 7]}}
{"token": ["Hereditary", "neuropathy", "liability", "to", "pressure", "palsies", "HNPP", ")", "is", "an", "C3899989#ent", "<e1>", "by", "recurrent", "C0031117#ent", "<e2>"], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [14, 15]}}
{"token": ["C1970848#ent", "<e1>", "an", "X-linked", "recessive", "usually", "associated", "with", "hemolytic", "anemia", "mental", "retardation", "and", "C0036572#ent", "<e2>", ";", "myopathy", "had", "not", "been", "recognized", "previously", "."], "h": {"id": "C1970848", "name": "C1970848#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "immunization", "by", "C0030956#ent", "<e1>", ",", "corresponding", "to", "the", "target", "sequences", "for", "anti-receptor", "autoantibodies", "C2931157#ent", "<e2>", "induces", "morphological", "changes", "in", "the", "heart", "similar", "to", "those", "found", "in", "the", "human", "disease"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2931157", "name": "C2931157#ent", "pos": [17, 18]}}
{"token": ["Pulmonary", "alveolar", "proteinosis", "C1423108#ent", "<e1>", ")", "is", "a", "rare", "C0034049#ent", "<e2>", "by", "the", "accumulation", "of", "lipoproteinaceous", "material", "within", "the", "alveoli", "."], "h": {"id": "C1423108", "name": "C1423108#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034049", "name": "C0034049#ent", "pos": [9, 10]}}
{"token": ["Using", "C0017837#ent", "<e1>", "we", "demonstrate", "that", "Pbx1", "and", "C1418611#ent", "<e2>", "interact", "with", "Smads", "2", "and", "3", "as", "well", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418611", "name": "C1418611#ent", "pos": [8, 9]}}
{"token": ["We", "have", "examined", "the", "hypothesis", "that", "the", "severe", "congenital", "form", "C0027126#ent", "<e1>", "caused", "by", "C1708477#ent", "<e2>", "the", "level", "of", "differential", "DNA", "methylation", "maternal", "and", "paternal", "alleles"], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1708477", "name": "C1708477#ent", "pos": [14, 15]}}
{"token": ["On", "the", "other", "hand", ",", "interleukin-1beta-converting", "enzyme", "ICE", ")", "is", "a", "mammalian", "homologue", "of", "C3279807#ent", "<e1>", ",", "a", "protein", "required", "for", "apoptosis", "in", "the", "nematode", "C0949990#ent", "<e2>"], "h": {"id": "C3279807", "name": "C3279807#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0949990", "name": "C0949990#ent", "pos": [25, 26]}}
{"token": ["Inhibition", "of", "C1412322#ent", "<e1>", "membrane", "translocation", "PKC-beta2", "and", "-delta", "delayed", "the", "activation", "of", "C3710929#ent", "<e2>", "and", "-epsilon", ",", "whereas", "membrane", "translocation", "PKC-alpha", "and", "-gamma", "was", "not", "affected", "."], "h": {"id": "C1412322", "name": "C1412322#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3710929", "name": "C3710929#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "our", "results", "suggest", "that", "there", "is", "currently", "no", "justification", "for", "the", "use", "of", "C0055461#ent", "<e1>", "to", "treat", "C0008055#ent", "<e2>"], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008055", "name": "C0008055#ent", "pos": [20, 21]}}
{"token": ["C0037317#ent", "<e1>", "a", "frequent", "complaint", "in", "C0023890#ent", "<e2>", "--", "may", "be", "part", "of", "the", "spectrum", "of", "SHE", "."], "h": {"id": "C0037317", "name": "C0037317#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [6, 7]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "the", "effect", "of", "C0919289#ent", "<e1>", "on", "human", "topoisomerases", "I", "C3273406#ent", "<e2>", "and", "its", "relevance", "for", "DNA", "integrity", "human", "cells"], "h": {"id": "C0919289", "name": "C0919289#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [16, 17]}}
{"token": ["Fraction", "III", "hulls", "had", "the", "highest", "content", "of", "total", "phenolics", "and", "C0919289#ent", "<e1>", "but", "no", "condensed", "tannins", "were", "detected", "in", "fractions", "I", "C3273406#ent", "<e2>", "from", "hulls", "."], "h": {"id": "C0919289", "name": "C0919289#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [22, 23]}}
{"token": ["Incubation", "with", "the", "JNK", "inhibitor", "C0968383#ent", "<e1>", "inhibited", "the", "C1425775#ent", "<e2>", "expression", "induced", "by", "IL-2/IL-18", "in", "the", "TGF-beta", "treated", "human", "NK", "cell", "line"], "h": {"id": "C0968383", "name": "C0968383#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425775", "name": "C1425775#ent", "pos": [9, 10]}}
{"token": ["C0029994#ent", "<e1>", "produced", "an", "increase", "in", "the", "tonus", "and", "spontaneous", "activity", "the", "C0018889#ent", "<e2>", "."], "h": {"id": "C0029994", "name": "C0029994#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [12, 13]}}
{"token": ["The", "hypophosphatemic", "male", "mouse", "resembles", "human", "males", "with", "X-linked", "hypophosphatemia", "the", "C0733682#ent", "<e1>", "presemably", "homologous", "with", "the", "C0678928#ent", "<e2>"], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [17, 18]}}
{"token": ["The", "hypophosphatemic", "male", "mouse", "resembles", "human", "males", "with", "C0733682#ent", "<e1>", "the", "Hyp", "gene", "presemably", "homologous", "with", "the", "C0678928#ent", "<e2>"], "h": {"id": "C0733682", "name": "C0733682#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [17, 18]}}
{"token": ["The", "results", "provide", "further", "evidence", "that", "autophosphorylation", "of", "the", "C0014442#ent", "<e1>", "affects", "the", "interaction", "between", "the", "C1447683#ent", "<e2>", "the", "catalytic", "center", "the", "C0014442#ent", "<e1>", "by", "facilitating", "the", "activation", "of", "the", "phosphotransferase", "reaction"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1447683", "name": "C1447683#ent", "pos": [16, 17]}}
{"token": ["These", "three", "C0014442#ent", "<e1>", "forms", "have", "identical", "kinetic", "constants", ",", "e.g.", "number", "of", "C1447683#ent", "<e2>", "Km", "values", "for", "MgATP", "and", "the", "heptapeptide", "kemptide", ",", "and", "Vmax", "values", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1447683", "name": "C1447683#ent", "pos": [13, 14]}}
{"token": ["The", "humoral", "response", "S.", "typhi-LPS", "was", "also", "greatly", "decreased", "after", "C0019693#ent", "<e1>", "in", "contrast", "to", "the", "known", "C0154254#ent", "<e2>", "seen", "in", "these", "subjects", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0154254", "name": "C0154254#ent", "pos": [17, 18]}}
{"token": ["3", "C1136365#ent", "<e1>", "a", "high", "capacity", "for", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}}
{"token": ["The", "depression", "of", "the", "specific", "activity", "of", "the", "C1136365#ent", "<e1>", "on", "the", "dose", "of", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["Although", "real-time", "ultrasound", "improved", "sensitivity", "over", "static", "gray-scale", "imaging", "for", "identification", "of", "C2609268#ent", "<e1>", "hepatobiliary", "scintigraphy", "the", "procedure", "of", "choice", "for", "C0008325#ent", "<e2>", "detection", "."], "h": {"id": "C2609268", "name": "C2609268#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0008325", "name": "C0008325#ent", "pos": [21, 22]}}
{"token": ["The", "fluorescence", "depression", "greater", "with", "sulfabenzamide", "than", "with", "C0038670#ent", "<e1>", ",", "indicating", "that", "the", "former", "is", "more", "strongly", "bound", "to", "C0032857#ent", "<e2>", "."], "h": {"id": "C0038670", "name": "C0038670#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032857", "name": "C0032857#ent", "pos": [20, 21]}}
{"token": ["The", "benzylidenesuccinic", "acid", "derivative", "24", "was", "equal", "both", "to", "C0903898#ent", "<e1>", "in", "potency", "of", "insulin-releasing", "activity", "to", "C0071097#ent", "<e2>", "in", "insulin-sensitizing", "activity", "."], "h": {"id": "C0903898", "name": "C0903898#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0071097", "name": "C0071097#ent", "pos": [17, 18]}}
{"token": ["In", "the", "stationary", "phase", "reached", "8", "d", "after", "transfer", "to", "a", "new", "medium", ",", "the", "formation", "of", "stilbenes", "and", "C0075258#ent", "<e1>", "be", "induced", "without", "altering", "the", "levels", "of", "other", "C3541394#ent", "<e2>", "."], "h": {"id": "C0075258", "name": "C0075258#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [29, 30]}}
{"token": ["Chalcone", "synthase", "CHS", ")", "and", "C0075258#ent", "<e1>", "STS", ")", "are", "closely", "related", "polyketide", "synthases", "are", "key", "C3541394#ent", "<e2>", "in", "the", "biosynthesis", "of", "flavonoids", "and", "stilbenes", "."], "h": {"id": "C0075258", "name": "C0075258#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["Concentrations", "of", "C1428905#ent", "<e1>", "in", "AD", "patients", "overlapped", "those", "in", "both", "normal", "subjects", "patients", "with", "C0011263#ent", "<e2>", "so", "that", "changes", "in", "CSF", "C1428905#ent", "<e1>", "have", "no", "diagnostic", "specificity"], "h": {"id": "C0011263", "name": "C0011263#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1428905", "name": "C1428905#ent", "pos": [2, 3]}}
{"token": ["A", "general", "method", "the", "syntheses", "of", "no-carrier-added", "(", "NCA", ")", "18F-labeled", "C0006525#ent", "<e1>", "benperidol", ",", "haloperidol", ",", "C0037956#ent", "<e2>", ",", "and", "pipamperone", "is", "described", "."], "h": {"id": "C0006525", "name": "C0006525#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037956", "name": "C0037956#ent", "pos": [17, 18]}}
{"token": ["C0911469#ent", "<e1>", "is", "a", "dominant-negative", "regulator", "C1366479#ent", "<e2>", "(", "IL-1beta-converting", "enzyme", "and", "an", "attenuator", "of", "cytokine", "responsiveness", "septic", "infections"], "h": {"id": "C0911469", "name": "C0911469#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366479", "name": "C1366479#ent", "pos": [6, 7]}}
{"token": ["In", "fact", ",", "the", "LPS-induced", "alterations", "in", "the", "expression", "of", "C1423607#ent", "<e1>", "as", "well", "as", "C1833296#ent", "<e2>", "and", "FPN1", "were", "preserved", "in", "the", "alveolar", "macrophages", "isolated", "from", "IL-1", "receptor", "IL-6-deficient", "mice", "."], "h": {"id": "C1423607", "name": "C1423607#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1833296", "name": "C1833296#ent", "pos": [15, 16]}}
{"token": ["Orlistat", ",", "an", "inhibitor", "of", "C0443469#ent", "<e1>", "is", "currently", "approved", "as", "an", "C0376607#ent", "<e2>"], "h": {"id": "C0443469", "name": "C0443469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0376607", "name": "C0376607#ent", "pos": [12, 13]}}
{"token": ["Most", "tellingly", ",", "the", "BBSome", "associates", "with", "C1424340#ent", "<e1>", ",", "the", "guanine", "nucleotide", "exchange", "factor", "the", "small", "GTPase", "C1706553#ent", "<e2>", ",", "and", "Rab8-GTP", "enters", "the", "primary", "cilium", "to", "promote", "extension", "of", "the", "ciliary", "membrane"], "h": {"id": "C1424340", "name": "C1424340#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706553", "name": "C1706553#ent", "pos": [18, 19]}}
{"token": ["C0268487#ent", "<e1>", "of", "corticotrophin", "(", "C1704793#ent", "<e2>", ")", ",", "growth", "hormone", "and", "prolactin", "were", "documented", "in", "a", "woman", "with", "diabetes", "mellitus", "Sheehan's", "syndrome"], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [5, 6]}}
{"token": ["The", "results", "presented", "here", "suggest", "that", "C0030956#ent", "<e1>", "surrogate", "ligands", "may", "be", "useful", "in", "formatting", "C1854310#ent", "<e2>", "for", "proteins", "with", "difficult", "biochemical", "assays", "targets", "of", "unknown", "function", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1854310", "name": "C1854310#ent", "pos": [15, 16]}}
{"token": ["Protein", "S", "functions", "as", "a", "cofactor", "to", "C1170000#ent", "<e1>", "APC", ")", "in", "the", "degradation", "of", "FVa", "and", "C1704822#ent", "<e2>", "."], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704822", "name": "C1704822#ent", "pos": [17, 18]}}
{"token": ["The", "factor", "V", "FV", ")", "B-domain", "is", "extremely", "important", "to", "the", "cofactor", "function", "native", "FV", "for", "C1170000#ent", "<e1>", "APC", ")", "in", "the", "inactivation", "of", "factor", "VIII", "C1704822#ent", "<e2>", ")", "."], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704822", "name": "C1704822#ent", "pos": [26, 27]}}
{"token": ["The", "glycoprotein", "VI", "agonist", "collagen-related", "peptide", "(", "C1826658#ent", "<e1>", ")", "and", "thrombin", "stimulated", "tyrosine", "phosphorylation", "C1336926#ent", "<e2>", "but", "not", "Vav2", "in", "human", "platelets", "."], "h": {"id": "C1826658", "name": "C1826658#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336926", "name": "C1336926#ent", "pos": [15, 16]}}
{"token": ["Terrein", "was", "found", "to", "downregulate", "C1332695#ent", "<e1>", "Cdc2", "without", "Cdc2", "phosphorylation", ",", "but", "upregulated", "C1332737#ent", "<e2>", "p27", ")", ",", "a", "known", "inhibitor", "of", "cyclin-dependent", "kinase"], "h": {"id": "C1332695", "name": "C1332695#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [14, 15]}}
{"token": ["C0001990#ent", "<e1>", "(", "EC", "4.1.2.13", "are", "ancient", "C3541394#ent", "<e2>", "of", "glycolysis", "that", "catalyze", "the", "reversible", "cleavage", "of", "phosphofructose", "esters", "cognate", "triose", "(", "phosphates", ")", "."], "h": {"id": "C0001990", "name": "C0001990#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}}
{"token": ["To", "study", "the", "effect", "of", "Chinese", "herbal", "medicine", "C0008525#ent", "<e1>", ")", "based", "on", "C1848862#ent", "<e2>", "Differentiation", "on", "postcardiotomic", "complications", "in", "patients", "with", "angiocardiopathy", "."], "h": {"id": "C0008525", "name": "C0008525#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [13, 14]}}
{"token": ["C3540725#ent", "<e1>", "are", "potent", "C0003209#ent", "<e2>", "modulate", "human", "T-lymphocyte", "responses"], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003209", "name": "C0003209#ent", "pos": [4, 5]}}
{"token": ["C3540725#ent", "<e1>", "are", "potent", "C0003209#ent", "<e2>", "have", "become", "a", "mainstay", "of", "pharmacotherapy", "for", "allergic", "rhinitis"], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003209", "name": "C0003209#ent", "pos": [4, 5]}}
{"token": ["Previously", ",", "we", "screened", "the", "human", "C0003692#ent", "<e1>", "variations", "because", "genetic", "variability", "C1332082#ent", "<e2>", "might", "influence", "these", "diseases", "."], "h": {"id": "C0003692", "name": "C0003692#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332082", "name": "C1332082#ent", "pos": [12, 13]}}
{"token": ["C2936882#ent", "<e1>", "profoundly", "blocked", "the", "nuclear", "translocation", "p65", ",", "C0035018#ent", "<e2>", ",", "and", "Rel-B", ",", "partially", "blocked", "p52", ",", "but", "permitted", "translocation", "of", "p50", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035018", "name": "C0035018#ent", "pos": [9, 10]}}
{"token": ["Venous", "blood", "assayed", "for", "molecular", "markers", "skeletal", "[", "C1417048#ent", "<e1>", "and", "total", "creatine", "phosphokinase", "CPK", ")", "]", "and", "myocardial", "[", "cardiac", "troponin", "I", "C3538828#ent", "<e2>", ")", "]", "muscle", "damage"], "h": {"id": "C1417048", "name": "C1417048#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3538828", "name": "C3538828#ent", "pos": [23, 24]}}
{"token": ["The", "annual", "mean", "C1414404#ent", "<e1>", "concentration", "varies", "from", "approximately", "1", "microg", "C1328200#ent", "<e2>", "in", "Northern", "Ireland", "approximately", "7", "microg", "C1328200#ent", "<e2>", "in", "East", "Anglia", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1328200", "name": "C1328200#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "indicate", "that", "C0018802#ent", "<e1>", "is", "a", "condition", "accompanied", "by", "C1416870#ent", "<e2>", "skeletal", "muscle", "dysfunction"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416870", "name": "C1416870#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "7-year-old", "girl", "with", "C3280182#ent", "<e1>", "presented", "with", "extremely", "rare", "central", "nervous", "system", "anomalies", "microcephaly", ",", "C0014544#ent", "<e2>", ",", "mental", "retardation", "intracranial", "calcifications", "addition", "to", "the", "classical", "scalp", "limb", "defects"], "h": {"id": "C3280182", "name": "C3280182#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "C2347281#ent", "<e1>", "the", "alpha", "5", "chain", "of", "type", "IV", "collagen", "been", "found", "in", "linkage", "with", "C1567741#ent", "<e2>", "AS", ")", "."], "h": {"id": "C2347281", "name": "C2347281#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C1567741", "name": "C1567741#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "C2347281#ent", "<e1>", "located", "at", "Xq22", ",", "cause", "C1567741#ent", "<e2>", "AS", ")", ",", "a", "nephritis", "characterized", "by", "progressive", "deterioration", "of", "the", "glomerular", "basement", "membrane", "usually", "associated", "with", "progressive", "hearing", "loss"], "h": {"id": "C2347281", "name": "C2347281#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C1567741", "name": "C1567741#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "there", "have", "been", "several", "recent", "discoveries", "into", "the", "genetics", "of", "generalized", "epilepsy", "C0009952#ent", "<e1>", ",", "a", "group", "of", "C0014556#ent", "<e2>", "by", "multiple", "seizure", "phenotypes", "."], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [21, 22]}}
{"token": ["This", "study", "aimed", "to", "examine", "the", "close", "correlation", "between", "complicated", "C0009952#ent", "<e1>", "CFC", ")", "and", "medial", "temporal", "lobe", "epilepsy", "to", "delineate", "characteristics", "of", "C0014556#ent", "<e2>", "CFC", "."], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [23, 24]}}
{"token": ["Likewise", ",", "the", "[", "Asp1", ",", "Val5", ",", "His9]ANG", "I-induced", "C0237795#ent", "<e1>", "effect", "was", "completely", "eliminated", "by", "an", "ANG", "C0039534#ent", "<e2>", "SQ", "14,225"], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039534", "name": "C0039534#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "have", "examined", "the", "molecular", "basis", "the", "interaction", "between", "C1413258#ent", "<e1>", "phosphatases", "and", "14", "-", "3", "-", "3", "C0086376#ent", "<e2>", "."], "h": {"id": "C1413258", "name": "C1413258#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "report", "that", "alternate", "splicing", "produces", "at", "least", "five", "variants", "of", "C1413258#ent", "<e1>", ",", "although", "only", "cdc25B2", "and", "cdc25B3", "are", "detectable", "as", "C0086376#ent", "<e2>", "."], "h": {"id": "C1413258", "name": "C1413258#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "report", "that", "alternate", "splicing", "produces", "at", "least", "five", "variants", "of", "cdc25B", ",", "although", "only", "cdc25B2", "and", "C1413258#ent", "<e1>", "are", "detectable", "as", "C0086376#ent", "<e2>", "."], "h": {"id": "C1413258", "name": "C1413258#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [23, 24]}}
{"token": ["The", "distinction", "between", "C0029888#ent", "<e1>", "AOM", ")", "and", "C0029882#ent", "<e2>", "effusion", "(", "OME", ")", "is", "important", "for", "antibiotic", "treatment", "."], "h": {"id": "C0029888", "name": "C0029888#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [8, 9]}}
{"token": ["C0029888#ent", "<e1>", "CSOM", ")", ",", "a", "severe", "form", "of", "C0029882#ent", "<e2>", "affects", "most", "Australian", "Aboriginal", "children", "up", "to", "50", "%", "in", "some", "communities", "suffering", "hearing", "loss", "a", "consequence", "."], "h": {"id": "C0029888", "name": "C0029888#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [9, 10]}}
{"token": ["Some", "of", "the", "new", "C0030956#ent", "<e1>", "approximated", "the", "antineoplastic", "potency", "of", "C0082338#ent", "<e2>", "especially", "those", "based", "on", "replacement", "of", "the", "Doe", "unit", "with", "Met", ",", "Phe", "or", "an", "appropriately", "substituted", "phenylethylamide", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0082338", "name": "C0082338#ent", "pos": [11, 12]}}
{"token": ["Dolastatin", "10", "15", "are", "small", "C0030956#ent", "<e1>", ";", "most", "preclinical", "studies", "used", "C0082338#ent", "<e2>"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0082338", "name": "C0082338#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "a", "plausible", "structural", "model", "the", "adaptability", "of", "C0917721#ent", "<e1>", "recognize", "substrates", "in", "the", "presence", "of", "C0206526#ent", "<e2>", "mutations", "has", "been", "proposed", "."], "h": {"id": "C0917721", "name": "C0917721#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0206526", "name": "C0206526#ent", "pos": [17, 18]}}
{"token": ["C0004943#ent", "<e1>", "a", "chronic", "inflammatory", "disease", "by", "recurrent", "C2937365#ent", "<e2>", "systemic", "manifestations"], "h": {"id": "C0004943", "name": "C0004943#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2937365", "name": "C2937365#ent", "pos": [8, 9]}}
{"token": ["Therefore", "initial", "intensive", "combined", "treatment", "with", "two", "or", "more", "C0003308#ent", "<e1>", "including", "rifampicin", ")", "warrants", "further", "investigation", "in", "both", "untreated", "C0023343#ent", "<e2>", "and", "lepromatous", "leprosy", "resistant", "to", "dapsone", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [20, 21]}}
{"token": ["In", "the", "present", "study", ",", "we", "assessed", "the", "hypothesis", "that", "mRNA", "expression", "levels", "of", "candidate", "genes", "of", "C0004153#ent", "<e1>", "in", "circulating", "CD14(+", ")", "blood", "monocytes", "are", "associated", "with", "C1956346#ent", "<e2>", "CHD", ")", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [28, 29]}}
{"token": ["To", "investigate", "the", "prevalence", "of", "cervical", "and", "C0004153#ent", "<e1>", "silent", "brain", "infarction", "patients", "with", "C1956346#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["C0079301#ent", "<e1>", "JEB", ")", "is", "a", "clinically", "and", "biologically", "C0037277#ent", "<e2>", "characterized", "by", "trauma-induced", "blistering", "and", "healing", "without", "scarring", "but", "sometimes", "with", "skin", "atrophy"], "h": {"id": "C0079301", "name": "C0079301#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [9, 10]}}
{"token": ["The", "results", "reveal", "that", "the", "downstream", "targets", "of", "AIbZIP", "include", "C0017337#ent", "<e1>", "that", "are", "implicated", "in", "protein", "processing", "e.g.", ",", "C1412731#ent", "<e2>", ",", "DNAJC12", ",", "KDELR3", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412731", "name": "C1412731#ent", "pos": [20, 21]}}
{"token": ["The", "proteins", "corresponded", "to", "C3541915#ent", "<e1>", ",", "a", "stearoyl-acyl", "carrier", "protein", "desaturase", "PepA", ",", "a", "C0036734#ent", "<e2>", "the", "Apa", "antigen", "which", "is", "the", "ATP-binding", "subunit", "an", "ABC", "transport", "system"], "h": {"id": "C3541915", "name": "C3541915#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [15, 16]}}
{"token": ["In", "3.5", "%", "C0040147#ent", "<e1>", "was", "diagnosed", ",", "75", "%", "struma", "lymphomatosa", "Hashimoto", "25", "%", "C0040149#ent", "<e2>", "Quervain", "."], "h": {"id": "C0040147", "name": "C0040147#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0040149", "name": "C0040149#ent", "pos": [15, 16]}}
{"token": ["In", "two", "patients", "with", "C0040147#ent", "<e1>", "caused", "by", "Coccidioides", "immitis", "presented", "thyroid", "symptoms", "findings", "were", "characteristic", "of", "C0040149#ent", "<e2>"], "h": {"id": "C0040147", "name": "C0040147#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0040149", "name": "C0040149#ent", "pos": [17, 18]}}
{"token": ["Studies", "with", "activators", "and", "inhibitors", "suggested", "that", "lipoamidase", "in", "serum", "using", "lipoylPABA", "as", "substrate", "may", "be", "a", "different", "C0014442#ent", "<e1>", "from", "that", "using", "C0125975#ent", "<e2>", "as", "substrate", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0125975", "name": "C0125975#ent", "pos": [23, 24]}}
{"token": ["The", "presence", "of", "factor", "V", "C0584960#ent", "<e1>", "determined", "by", "amplifying", "the", "fragments", "encompassing", "C0678941#ent", "<e2>", "PCR", "."], "h": {"id": "C0584960", "name": "C0584960#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0678941", "name": "C0678941#ent", "pos": [13, 14]}}
{"token": ["The", "course", "of", "cystoid", "macular", "oedema", "C1413857#ent", "<e1>", ")", "following", "extracapsular", "cataract", "extraction", "posterior", "chamber", "intraocular", "lens", "implantation", "prospectively", "studied", "in", "44", "C0235267#ent", "<e2>", "of", "44", "consecutive", "diabetic", "patients", "without", "preoperative", "C1413857#ent", "<e1>", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1413857", "name": "C1413857#ent", "pos": [6, 7]}}
{"token": ["It", "was", "found", "that", "ICl", "reacts", "quantitatively", "only", "with", "C0054741#ent", "<e1>", "and", "tranylcypromine", "sulphate", "with", "C0022059#ent", "<e2>", "results", "were", "very", "poor", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022059", "name": "C0022059#ent", "pos": [15, 16]}}
{"token": ["Nitrofurazone", "and", "C0028156#ent", "<e1>", "are", "the", "only", "C0028155#ent", "<e2>", "that", "have", "become", "established", "in", "clinical", "use", "the", "20th", "century", "."], "h": {"id": "C0028156", "name": "C0028156#ent", "pos": [2, 3]}, "relation": "has_chemical_structure", "t": {"id": "C0028155", "name": "C0028155#ent", "pos": [7, 8]}}
{"token": ["We", "describe", "a", "case", "of", "C1843273#ent", "<e1>", "a", "13-year-old", "girl", "with", "multiple", "tubular", "dysfunctions", "renal", "glucosuria", "tubular", "proteinuria", "phosphaturia", ",", "C0151582#ent", "<e2>", ",", "and", "concentrating", "and", "acidifying", "defect", "."], "h": {"id": "C1843273", "name": "C1843273#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151582", "name": "C0151582#ent", "pos": [20, 21]}}
{"token": ["Human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "infection", "and", "the", "consequent", "acquired", "C0494261#ent", "<e1>", "AIDS", ")", "has", "C0029166#ent", "<e2>", "including", "muscle", "wasting", "cardiomyopathy", ",", "which", "contribute", "to", "its", "high", "morbidity"], "h": {"id": "C0494261", "name": "C0494261#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [17, 18]}}
{"token": ["Mature", "C1415468#ent", "<e1>", "is", "composed", "of", "three", "C0599220#ent", "<e2>", ",", "designated", "as", "alpha", ",", "beta", ",", "and", "gamma", ",", "with", "molecular", "masses", "39", ",", "19", ",", "and", "16", "kDa", ",", "respectively", "."], "h": {"id": "C1415468", "name": "C1415468#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [7, 8]}}
{"token": ["C0546864#ent", "<e1>", "children", "presenting", "to", "the", "emergency", "department", "ED", ")", "with", "C0030193#ent", "<e2>", "determine", "if", "nebulized", "fentanyl", "is", "a", "feasible", "alternative", "to", "i.v", "."], "h": {"id": "C0546864", "name": "C0546864#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [11, 12]}}
{"token": ["The", "latter", "also", "inhibits", "C1417708#ent", "<e1>", "induced", "by", "overexpression", "of", "C1335623#ent", "<e2>", "TNF", "receptor-associated", "factor", "2"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335623", "name": "C1335623#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", "the", "mRNA", "and", "protein", "levels", "the", "key", "C3540790#ent", "<e1>", "involved", "in", "eicosanoid", "biosynthesis", "the", "cysteinyl", "leukotriene", "receptors", "CysLT1R", "and", "C1425412#ent", "<e2>", ")", "have", "been", "analysed", "in", "non-transformed", "intestinal", "epithelial", "and", "colon", "cancer", "cell", "lines"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1425412", "name": "C1425412#ent", "pos": [22, 23]}}
{"token": ["C0268595#ent", "<e1>", "GA-I", ")", "is", "associated", "with", "onset", "of", "irreversible", ",", "disabling", "C0393593#ent", "<e2>", "between", "3", "and", "18", "months", "of", "age", "."], "h": {"id": "C0268595", "name": "C0268595#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [12, 13]}}
{"token": ["The", "autosomal", "recessive", "inherited", "disorder", "C0268595#ent", "<e1>", "glutaric", "aciduria", "runs", "a", "progressive", "course", "with", "severe", "choreoathetosis", "and", "C0393593#ent", "<e2>", ",", "eventually", "leading", "to", "total", "helplessness", "and", "early", "death"], "h": {"id": "C0268595", "name": "C0268595#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [17, 18]}}
{"token": ["Their", "accumulation", "requires", "C0287666#ent", "<e1>", "is", "counteracted", "by", "Srs2", "C0920283#ent", "<e2>", "and", "does", "not", "prevent", "fork", "movement"], "h": {"id": "C0287666", "name": "C0287666#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0920283", "name": "C0920283#ent", "pos": [9, 10]}}
{"token": ["Normally", ",", "there", "are", "two", "21-OH", "genes", ";", "a", "pseudogene", "(", "C1413861#ent", "<e1>", ")", "and", "a", "functional", "gene", "C1522419#ent", "<e2>", ")", "."], "h": {"id": "C1413861", "name": "C1413861#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1522419", "name": "C1522419#ent", "pos": [18, 19]}}
{"token": ["The", "C1413861#ent", "<e1>", "encoding", "the", "C1522419#ent", "<e2>", "enzyme", "of", "adrenal", "steroid", "biosynthesis", "has", "been", "mapped", "to", "the", "human", "major", "histocompatibility", "complex", "(", "MHC", ")", "."], "h": {"id": "C1413861", "name": "C1413861#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1522419", "name": "C1522419#ent", "pos": [5, 6]}}
{"token": ["In", "all", "of", "our", "late-onset", "adrenal", "hyperplasia", "patients", ",", "hybridization", "of", "an", "oligonucleotide", "probe", "for", "this", "mutation", "was", "demonstrated", "to", "C1413861#ent", "<e1>", "but", "not", "to", "C1522419#ent", "<e2>", "."], "h": {"id": "C1413861", "name": "C1413861#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1522419", "name": "C1522419#ent", "pos": [25, 26]}}
{"token": ["The", "clinical", "syndromes", "primary", "bacteremia", "in", "5", "patients", "(", "42", "%", ")", ",", "C0920156#ent", "<e1>", "3", "(", "25", "%", ")", ",", "and", "peritonitis", ",", "C0038539#ent", "<e2>", "infusion-related", "bacteremia", "and", "pneumonia", "in", "1", "each", "."], "h": {"id": "C0920156", "name": "C0920156#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038539", "name": "C0038539#ent", "pos": [24, 25]}}
{"token": ["We", "examined", "samples", "of", "serum", "from", "Japanese", "patients", "with", "unclassified", "uveitis", "iridocyclitis", "caused", "by", "herpes", "zoster", "virus", "Beh\u00e7et's", "disease", "C0042170#ent", "<e1>", "sarcoidosis", ",", "or", "other", "conditions", "(", "sympathetic", "ophthalmia", "Posner-Schlossman", "syndrome", "C0701807#ent", "<e2>", "ankylosing", "spondylitis", "."], "h": {"id": "C0042170", "name": "C0042170#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0701807", "name": "C0701807#ent", "pos": [31, 32]}}
{"token": ["A", "positive", "antibody", "response", "recognized", "in", "several", "patients", "with", "Beh\u00e7et's", "disease", "C0042170#ent", "<e1>", "sarcoidosis", ",", "and", "other", "conditions", "(", "C0701807#ent", "<e2>", "ankylosing", "spondylitis", ",", "but", "not", "in", "control", "subjects"], "h": {"id": "C0042170", "name": "C0042170#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0701807", "name": "C0701807#ent", "pos": [19, 20]}}
{"token": ["The", "candidate", "region", "was", "14.7", "cM", "flanked", "by", "D3S1620", "and", "D3S3691", ",", "which", "was", "partly", "overlapping", "with", "the", "locus", "of", "C1847725#ent", "<e1>", "characterized", "by", "pure", "C0007758#ent", "<e2>"], "h": {"id": "C1847725", "name": "C1847725#ent", "pos": [20, 21]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [25, 26]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "prostanoid", "production", "in", "pregnancies", "at", "high", "risk", "C0020538#ent", "<e1>", "and", "the", "effect", "of", "C0101202#ent", "<e2>", "ASA", ")", "on", "prostanoids", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0101202", "name": "C0101202#ent", "pos": [22, 23]}}
{"token": ["Since", "C1418552#ent", "<e1>", "PNI", ")", ",", "a", "C0035179#ent", "<e2>", "homologous", "with", "CrmA", ",", "prevents", "apoptosis", "of", "lumbar", "motor", "neurons", "is", "increased", "after", "nerve", "injury", "we", "examined", "mRNA", "by", "RT-PCR", "for", "PNI", "expression", "."], "h": {"id": "C1418552", "name": "C1418552#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [7, 8]}}
{"token": ["C1418552#ent", "<e1>", "PNI", ")", ",", "a", "serine", "protease", "inhibitor", "C0035179#ent", "<e2>", ")", ",", "is", "the", "most", "potent", "tissue", "inhibitor", "thrombin", "."], "h": {"id": "C1418552", "name": "C1418552#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "when", "Brattleboro", "rats", "were", "treated", "with", "C2698414#ent", "<e1>", "for", "2", "wk", ",", "the", "regulation", "of", "C2698414#ent", "<e1>", "C0079429#ent", "<e1>", "occurred", "in", "response", "to", "24", "h", "of", "fluid", "deprivation", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [20, 21]}}
{"token": ["Tumor", "necrosis", "factor", "receptor-associated", "periodic", "syndrome", "TRAPS", ")", "is", "a", "dominantly", "inherited", "C2698414#ent", "<e1>", "results", "from", "mutations", "in", "TNFRSF1A", ",", "the", "C0079429#ent", "<e2>", "that", "encodes", "the", "55-kd", "tumor", "necrosis", "factor", "receptor"], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [21, 22]}}
{"token": ["Tumor", "necrosis", "factor", "receptor-associated", "periodic", "syndrome", "TRAPS", ")", "is", "an", "C2698414#ent", "<e1>", "associated", "with", "mutations", "in", "the", "C0079429#ent", "<e2>", "that", "encodes", "tumor", "necrosis", "factor", "receptor", "superfamily", "1A", "TNFRSF1A", ")", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}}
{"token": ["A", "specific", "enzyme", "immunoassay", "C1421374#ent", "<e1>", "developed", "and", "applied", "to", "the", "detection", "of", "the", "human", "C0027203#ent", "<e2>", "in", "man-rodent", "somatic", "cell", "hybrids"], "h": {"id": "C1421374", "name": "C1421374#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["C1421374#ent", "<e1>", "Uro-d", ";", "EC", "4.1.1.37", ")", ",", "the", "fifth", "C0027203#ent", "<e2>", "in", "the", "heme", "biosynthetic", "pathway", "which", "catalyzes", "the", "sequential", "decarboxylation", "of", "uroporphyrinogen", "to", "coproporphyrinogen", "is", "encoded", "by", "the", "HEM12", "gene", "in", "Saccharomyces", "cerevisiae"], "h": {"id": "C1421374", "name": "C1421374#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["We", "performed", "a", "comparative", "study", "crab", "C1421374#ent", "<e1>", "with", "the", "C0027203#ent", "<e2>", "C1421374#ent", "<e1>", "present", "in", "Wistar", "rat", "liver", ",", "which", "is", "known", "as", "a", "useful", "indicator", "of", "intoxication", "by", "polyhalogenated", "aromatic", "hydrocarbons", "PAHs", ")", "."], "h": {"id": "C1421374", "name": "C1421374#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["A", "deficiency", "in", "the", "activity", "of", "C1421374#ent", "<e1>", "UROD", ")", ",", "the", "fifth", "C0027203#ent", "<e2>", "of", "the", "haem", "biosynthetic", "pathway", "is", "found", "in", "familial", "porphyria", "cutanea", "tarda", "F-PCT", ")", "and", "hepatoerythropoietic", "porphyria", "HEP", ")", "."], "h": {"id": "C1421374", "name": "C1421374#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}}
{"token": ["Amino-guanidine", "at", "0.1", "to", "0.2", "millimolar", "prevented", "Put", "degradation", "and", "greatly", "decreased", "oxidative", "degradation", "C2346451#ent", "<e1>", ";", "ornithine", "at", "15", "to", "20", "millimolar", "significantly", "inhibited", "C0003762#ent", "<e2>", "activity", "."], "h": {"id": "C2346451", "name": "C2346451#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003762", "name": "C0003762#ent", "pos": [25, 26]}}
{"token": ["In", "all", ",", "17", "(", "52", "percent", ")", "of", "33", "subsequent", "granulocytopenic", "episodes", "by", "patients", "with", "a", "prior", "C0032285#ent", "<e1>", "complicated", "by", "another", "fungal", "C1535939#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [24, 25]}}
{"token": ["The", "influence", "of", "C0022614#ent", "<e1>", "in", "promoting", "cell", "survival", "blocked", "by", "the", "C1516869#ent", "<e2>", "2-amino-5-phosphonovalerate", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [12, 13]}}
{"token": ["No", "patient", "demonstrated", "low", "values", "of", "C3538796#ent", "<e1>", "or", "carotene", "regardless", "of", "postoperative", "C0720099#ent", "<e2>", ",", "bowel", "segment", "location", "or", "length", "of", "segment"], "h": {"id": "C3538796", "name": "C3538796#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [13, 14]}}
{"token": ["Results", "showed", "that", "the", "capillary", "endothelial", "and", "type", "I", "epthelial", "cells", "were", "mainly", "damaged", ",", "and", "associated", "with", "C0013604#ent", "<e1>", "haemorrhage", "and", "hyaline", "membrane", "formation", "the", "alveoli", ",", "and", "accentuated", "C0002390#ent", "<e2>", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002390", "name": "C0002390#ent", "pos": [30, 31]}}
{"token": ["Transgenic", "mice", "generated", "with", "cardiac-specific", "overexpression", "of", "the", "G", "protein-coupled", "receptor", "kinase", "3", "C1332030#ent", "<e1>", ")", "to", "explore", "the", "in", "vivo", "of", "this", "C0872383#ent", "<e2>", "in", "cardiac", "function"], "h": {"id": "C1332030", "name": "C1332030#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0872383", "name": "C0872383#ent", "pos": [23, 24]}}
{"token": ["C1425192#ent", "<e1>", "binds", "to", "both", "C1418449#ent", "<e2>", "and", "mAT2", ";", "a", "mutation", "abolishing", "its", "binding", "to", "C1418449#ent", "<e2>", "greatly", "diminishes", "the", "activity", "of", "the", "promoter", "."], "h": {"id": "C1425192", "name": "C1425192#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418449", "name": "C1418449#ent", "pos": [5, 6]}}
{"token": ["We", "show", "that", "GM1", ",", "similarly", "to", "sphingosine", "1-phosphate", "protects", "rat", "heart", "fibroblasts", "apoptosis", "induced", "by", "the", "protein", "kinase", "C", "inhibitor", "C0075193#ent", "<e1>", "and", "by", "C0083632#ent", "<e2>", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0083632", "name": "C0083632#ent", "pos": [25, 26]}}
{"token": ["The", "following", "C3540772#ent", "<e1>", "were", "measured", "in", "leucocytes", ":", "Adenosine", "deaminase", "purine", "nucleoside", "phosphorylase", "C0001414#ent", "<e2>", "hypoxanthine", "phosphoribosyltransferase", "adenosine", "kinase"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001414", "name": "C0001414#ent", "pos": [14, 15]}}
{"token": ["Although", "C3539567#ent", "<e1>", "is", "known", "to", "inhibit", "C1565830#ent", "<e2>", "and", "thus", "the", "production", "of", "eicosanoids", ",", "indomethacin", "did", "not", "inhibit", "Ia", "expression"], "h": {"id": "C3539567", "name": "C3539567#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [7, 8]}}
{"token": ["The", "rank", "order", "of", "Ca2", "+", "antagonists", "competing", "for", "airway", "(3H)nitrendipine", "binding", "was", "nitrendipine", "not", "equal", "to", "C0028116#ent", "<e1>", "not", "equal", "to", "nifedipine", "much", "greater", "than", "C0280858#ent", "<e2>", "."], "h": {"id": "C0028116", "name": "C0028116#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [26, 27]}}
{"token": ["Nimodipine", "and", "C0028116#ent", "<e1>", "markedly", "reduce", "the", "enthalpy", "of", "transition", "while", "diltiazem", "and", "C0280858#ent", "<e2>", "have", "no", "significant", "effect", "on", "the", "enthalpy", "within", "the", "drug", "concentration", "studied", "."], "h": {"id": "C0028116", "name": "C0028116#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [13, 14]}}
{"token": ["The", "incidence", "of", "cells", "with", "chromosomal", "numerical", "aberrations", "aneuploidy", ")", "was", "increased", "in", "cells", "treated", "with", "tamoxifen", ",", "4-hydroxytamoxifen", ",", "toremifene", ",", "C0086213#ent", "<e1>", "and", "diethylstilbestrol", "but", "not", "C0244404#ent", "<e2>", "."], "h": {"id": "C0086213", "name": "C0086213#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0244404", "name": "C0244404#ent", "pos": [28, 29]}}
{"token": ["The", "higher", "dose", "of", "C0531201#ent", "<e1>", "and", "Nal-Arg", "remained", "effective", "in", "attenuating", "C4284134#ent", "<e2>", "production", "by", "luteal", "cells", "48", "h", "of", "incubation", "."], "h": {"id": "C0531201", "name": "C0531201#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4284134", "name": "C4284134#ent", "pos": [12, 13]}}
{"token": ["The", "C1254351#ent", "<e1>", "caused", "side", "effects", "of", "reddened", "skin", "lower", "lid", ",", "ocular", "irritation", "C0155169#ent", "<e2>", "headache", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0155169", "name": "C0155169#ent", "pos": [14, 15]}}
{"token": ["A", "broad", "spectrum", "C0037274#ent", "<e1>", "be", "encountered", "in", "patients", "with", "both", "type", "1", "C0011854#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}}
{"token": ["Transforming", "growth", "factor", "beta", "(", "TGFbeta", ")", ",", "a", "cytokine", "involved", "in", "the", "C1710463#ent", "<e1>", "several", "acute-phase", "plasma", "proteins", "antagonized", "the", "glucocorticoid-dependent", "induction", "of", "alpha1-acid", "C0072522#ent", "<e2>", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [25, 26]}}
{"token": ["These", "C0035064#ent", "<e1>", "also", "appear", "to", "decrease", "the", "severity", "of", "C0152169#ent", "<e2>"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0152169", "name": "C0152169#ent", "pos": [10, 11]}}
{"token": ["C1412841#ent", "<e1>", "Btk", ")", "is", "a", "recently", "described", "C3853652#ent", "<e2>"], "h": {"id": "C1412841", "name": "C1412841#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3853652", "name": "C3853652#ent", "pos": [8, 9]}}
{"token": ["Dibutyryl", "cAMP", ",", "an", "analogue", "of", "cAMP", ",", "and", "C0917964#ent", "<e1>", ",", "an", "adenylate", "cyclase", "activator", "mimicked", "the", "effect", "of", "C0538030#ent", "<e2>", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0538030", "name": "C0538030#ent", "pos": [20, 21]}}
{"token": ["AFB(1", ")", "exposure", "induces", "C1708115#ent", "<e1>", "such", "as", "RAD51", "and", "those", "encoding", "C0035547#ent", "<e2>", "RNR", ")", ",", "through", "a", "MEC1", "(", "ATR", "homolog)-dependent", "pathway", "."], "h": {"id": "C1708115", "name": "C1708115#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035547", "name": "C0035547#ent", "pos": [12, 13]}}
{"token": ["The", "function", "of", "the", "corneal", "epithelium", "evaluated", "in", "30", "patients", "with", "C0015397#ent", "<e1>", "whom", "no", "signs", "of", "C0010034#ent", "<e2>", "observed", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0010034", "name": "C0010034#ent", "pos": [17, 18]}}
{"token": ["The", "murine", "cytomegalovirus", "M45", "protein", "with", "C0297981#ent", "<e1>", "RIP", ")", "1", "and", "C3890354#ent", "<e2>", "via", "a", "RIP", "homotypic", "interaction", "motif"], "h": {"id": "C0297981", "name": "C0297981#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3890354", "name": "C3890354#ent", "pos": [12, 13]}}
{"token": ["Spironolactone", "is", "an", "C3536833#ent", "<e1>", "has", "been", "used", "as", "a", "C0304490#ent", "<e2>", "in", "treatment", "of", "ascites", "in", "liver", "failure"], "h": {"id": "C3536833", "name": "C3536833#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0304490", "name": "C0304490#ent", "pos": [10, 11]}}
{"token": ["Elevated", "C0073186#ent", "<e1>", "mRNA", "was", "accompanied", "by", "an", "increase", "in", "C0812235#ent", "<e2>", "as", "detected", "by", "C3-mediated", "[32P]ADP-ribosylation", "."], "h": {"id": "C0073186", "name": "C0073186#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812235", "name": "C0812235#ent", "pos": [10, 11]}}
{"token": ["In", "the", "epithelial", "cell", "line", "A549", ",", "IL-6", "and", "C1366571#ent", "<e1>", "mRNA", "levels", "were", "enhanced", "by", "C1947941#ent", "<e2>", "as", "a", "result", "of", "transcriptional", "induction", "the", "respective", "genes", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [16, 17]}}
{"token": ["We", "conclude", "that", "acute", "NPPV", "may", "be", "attempted", "in", "selected", "patients", "with", "C1145670#ent", "<e1>", "predominantly", "patients", "with", "C0035204#ent", "<e2>", "but", "that", "this", "procedure", "is", "very", "time-consuming", "for", "nurses", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [17, 18]}}
{"token": ["In", "our", "patient's", ",", "we", "added", "gradual", "blood", "contamination", "explain", "the", "progressive", "development", "of", "C1145670#ent", "<e1>", "the", "severity", "of", "the", "C0035204#ent", "<e2>", "to", "the", "massive", "dose", "injected", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [20, 21]}}
{"token": ["C1417614#ent", "<e1>", "is", "a", "C1415740#ent", "<e2>", "is", "up-regulated", "during", "neural", "and", "myogenic", "differentiation", "."], "h": {"id": "C1417614", "name": "C1417614#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [4, 5]}}
{"token": ["Eight", "patients", "with", "C0004099#ent", "<e1>", "in", "a", "single", "blind", "dose-duration", "study", "comparing", "the", "protective", "effect", "C0012694#ent", "<e2>", "SCG", ")", "in", "increasing", "concentrations", "from", "2", "to", "40", "g/l", "."], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [15, 16]}}
{"token": ["These", "enzyme", "cascades", "include", "C1744635#ent", "<e1>", "C", ",", "protein", "kinase", "C", "calcium/calmodulin", "and", "cAMP-dependent", "protein", "kinases", "C0001492#ent", "<e2>"], "h": {"id": "C1744635", "name": "C1744635#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [16, 17]}}
{"token": ["More", "recently", ",", "the", "mutation", "has", "been", "implicated", "in", "C0018784#ent", "<e1>", "patients", "without", "previous", "C0002556#ent", "<e2>"], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002556", "name": "C0002556#ent", "pos": [14, 15]}}
{"token": ["Seven", "(", "16", "%", ")", "had", "bilateral", "sensorineural", "hearing", "loss", "C0018784#ent", "<e1>", ")", "for", "high", "frequency", "sounds", ",", "consistent", "with", "C0002556#ent", "<e2>", "induced", "ototoxicity", "."], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002556", "name": "C0002556#ent", "pos": [20, 21]}}
{"token": ["In", "the", "PZX-5", "carcinoma", "line", "that", "was", "originally", "negative", ",", "the", "one", "month", "C0534628#ent", "<e1>", "treatment", "induced", "the", "strong", "expression", "of", "C0376515#ent", "<e2>", "a", "development", "of", "an", "acquired", "resistance", "programmed", "cell", "death", "this", "tumor", "."], "h": {"id": "C0534628", "name": "C0534628#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "addition", "of", "C0534628#ent", "<e1>", "led", "to", "a", "marked", "reduction", "of", "the", "C0376515#ent", "<e2>", "and", "Bcl-XL", "anti-apoptotic", "protein", "whereas", "Bax", "protein", "levels", "unaffected", "."], "h": {"id": "C0534628", "name": "C0534628#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "the", "epithelial", "cell", "homogenate", "with", "C0000294#ent", "<e1>", "to", "disrupt", "protein", "and", "C0072522#ent", "<e2>", "secondary", "structure", "inhibited", "the", "binding", "of", "V.", "cholerae", "strains", ",", "suggesting", "that", "binding", "was", "to", "specific", "receptors", "."], "h": {"id": "C0000294", "name": "C0000294#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "significant", "progress", "has", "been", "made", "in", "identifying", "C0694884#ent", "<e1>", "as", "a", "regulator", "of", "C0812327#ent", "<e2>", "cell", "proliferation", "apoptosis", ",", "and", "genome", "stability", "leading", "to", "a", "new", "model", "of", "understanding", "menin", "'s", "tumor-suppressing", "function"], "h": {"id": "C0694884", "name": "C0694884#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "we", "confirm", "that", "a", "CaM-binding", "peptide", "derived", "from", "MLCK", "(", "C0027120#ent", "<e1>", "inhibits", "IP3-evoked", "Ca2", "+", "release", "via", "all", "three", "C1705860#ent", "<e2>", "subtypes", "."], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705860", "name": "C1705860#ent", "pos": [25, 26]}}
{"token": ["By", "fusing", "the", "extracellular", "domain", "the", "receptor", "to", "an", "C0079686#ent", "<e1>", "ILZ", ")", "sequence", ",", "it", "is", "possible", "to", "generate", "C0034857#ent", "<e2>", "form", "trimers", "in", "solution", "."], "h": {"id": "C0079686", "name": "C0079686#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034857", "name": "C0034857#ent", "pos": [20, 21]}}
{"token": ["The", "enzyme", "deficiency", "associated", "with", "forms", "of", "hemoglobinopathies", ":", "alpha-", "and", "C4274391#ent", "<e1>", ",", "structurally", "abnormal", "hemoglobin", "S", "C0025637#ent", "<e2>", "."], "h": {"id": "C4274391", "name": "C4274391#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025637", "name": "C0025637#ent", "pos": [18, 19]}}
{"token": ["The", "C1848862#ent", "<e1>", "of", "familial/sporadic", "glucocorticoid", "resistance", "is", "characterized", "by", "hypercortisolism", "without", "C0342443#ent", "<e2>", "stigmata", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0342443", "name": "C0342443#ent", "pos": [12, 13]}}
{"token": ["Formalin-fixed", "paraffin-embedded", "biopsies", "from", "85", "patients", "with", "head", "and", "neck", "squamous", "cell", "carcinomas", "HNSCC", ")", "were", "stained", "and", "evaluated", "for", "the", "expression", "of", "integrin", "beta1", "C1423974#ent", "<e1>", "and", "beta6", "and", "C0694872#ent", "<e2>", "."], "h": {"id": "C1423974", "name": "C1423974#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [30, 31]}}
{"token": ["C0700480#ent", "<e1>", "was", "effective", "in", "reducing", "symptoms", "of", "C0155877#ent", "<e2>", "adults", "and", "reduced", "the", "relative", "risk", "developing", "asthma", "in", "infants", "with", "atopic", "dermatitis", "to", "grass", "pollen", "or", "house", "dust", "mite", "allergens", "."], "h": {"id": "C0700480", "name": "C0700480#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0155877", "name": "C0155877#ent", "pos": [8, 9]}}
{"token": ["C1420568#ent", "<e1>", "-", "6", "axonemes", "lack", "the", "C1305923#ent", "<e2>", "associated", "with", "I1", "inner", "arm", "complex", "."], "h": {"id": "C1420568", "name": "C1420568#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [7, 8]}}
{"token": ["For", "the", "same", "level", "of", "C2699120#ent", "<e1>", ",", "both", "cirrhotic", "groups", "excreted", "significantly", "less", "water", "and", "C3714642#ent", "<e2>", "than", "controls", "."], "h": {"id": "C2699120", "name": "C2699120#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [16, 17]}}
{"token": ["Neither", "the", "anti-androgens", "nor", "C0014930#ent", "<e1>", "can", "enhance", "AR", "transcriptional", "activity", "10(-11)-10(-7)M", "in", "C1704969#ent", "<e2>"], "h": {"id": "C0014930", "name": "C0014930#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704969", "name": "C1704969#ent", "pos": [13, 14]}}
{"token": ["Phenotolamine", ",", "an", "C3536752#ent", "<e1>", "competitively", "inhibited", "NE", "without", "altering", "the", "response", "to", "C3273406#ent", "<e2>"], "h": {"id": "C3536752", "name": "C3536752#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [13, 14]}}
{"token": ["We", "propose", "that", "Ayk1", ",", "C0971285#ent", "<e1>", "and", "Ipl1", "belong", "to", "a", "distinct", "new", "subfamily", "of", "C0031727#ent", "<e2>", "."], "h": {"id": "C0971285", "name": "C0971285#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [16, 17]}}
{"token": ["The", "Aurora", "kinase", "family", "of", "three", "members", ",", "C0971285#ent", "<e1>", "B", ",", "and", "C.", "The", "C0971285#ent", "<e1>", "C0031727#ent", "<e1>", "emerged", "as", "essential", "regulators", "of", "cell", "division"], "h": {"id": "C0971285", "name": "C0971285#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "show", "that", "the", "C1419699#ent", "<e1>", "absent", "from", "the", "C1563761#ent", "<e2>", "rice", "and", "has", "been", "transferred", "to", "the", "nucleus", "."], "h": {"id": "C1419699", "name": "C1419699#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1563761", "name": "C1563761#ent", "pos": [10, 11]}}
{"token": ["The", "association", "between", "DNA", "insertion", "sequences", "near", "the", "C1337112#ent", "<e1>", "the", "dominantly", "inherited", "C0342276#ent", "<e2>", "young", "people", "studied", "in", "a", "large", "family", "."], "h": {"id": "C1337112", "name": "C1337112#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0342276", "name": "C0342276#ent", "pos": [13, 14]}}
{"token": ["Especially", "in", "patients", "suffering", "C0022661#ent", "<e1>", "nonspecific", "constitutional", "symptoms", "sarcoidosis", "like", "fever", ",", "weight", "loss", "C0019559#ent", "<e2>", "and", "fatigue", "may", "be", "easily", "misleading", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019559", "name": "C0019559#ent", "pos": [15, 16]}}
{"token": ["The", "second", "is", "that", "villous", "hemorrhage", "endovasculitis", "or", "C1300128#ent", "<e1>", "is", "one", "important", "factor", "related", "to", "a", "low", "Apgar", "score", "C0015930#ent", "<e2>"], "h": {"id": "C1300128", "name": "C1300128#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015930", "name": "C0015930#ent", "pos": [20, 21]}}
{"token": ["C0020456#ent", "<e1>", "was", "induced", "in", "rats", "by", "the", "infusion", "of", "C0017740#ent", "<e2>"], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017740", "name": "C0017740#ent", "pos": [10, 11]}}
{"token": ["In", "this", "paper", ",", "we", "have", "induced", "C0020456#ent", "<e1>", "in", "zebrafish", "by", "alternately", "immersing", "the", "fish", "in", "C0017740#ent", "<e2>", "water", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017740", "name": "C0017740#ent", "pos": [17, 18]}}
{"token": ["Controlled", "trials", "demonstrated", "the", "safety", "and", "efficacy", "of", "C0025242#ent", "<e1>", "monotherapy", "for", "patients", "with", "moderate", "to", "severe", "C0002395#ent", "<e2>", "AD", ")", "but", "no", "controlled", "trials", "C0025242#ent", "<e1>", "in", "patients", "receiving", "a", "cholinesterase", "inhibitor", "been", "performed", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0025242", "name": "C0025242#ent", "pos": [8, 9]}}
{"token": ["We", "present", "the", "case", "history", "a", "22-yr-old", "woman", "diagnosed", "with", "C0162529#ent", "<e1>", "associated", "with", "use", "of", "oral", "contraceptives", "C1412791#ent", "<e2>", ")", "."], "h": {"id": "C0162529", "name": "C0162529#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [18, 19]}}
{"token": ["It", "acted", "neither", "on", "proline", "specific", "exopeptidases", "such", "as", "dipeptidyl", "aminopeptidase", "IV", "C0243766#ent", "<e1>", "prolidase", ",", "nor", "usual", "endopeptidases", "such", "as", "trypsin", "and", "C1413806#ent", "<e2>", "."], "h": {"id": "C0243766", "name": "C0243766#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413806", "name": "C1413806#ent", "pos": [23, 24]}}
{"token": ["In", "the", "C0002707#ent", "<e1>", ",", "OX1R", "mRNA", "was", "expressed", "throughout", "the", "amygdaloid", "complex", "robust", "labeling", "in", "the", "medial", "nucleus", "while", "C1540290#ent", "<e2>", "mRNA", "was", "only", "present", "in", "the", "posterior", "cortical", "nucleus", "C0002707#ent", "<e1>", "."], "h": {"id": "C1540290", "name": "C1540290#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0002707", "name": "C0002707#ent", "pos": [2, 3]}}
{"token": ["The", "C1709995#ent", "<e1>", "polymorphic", "site", "used", "as", "a", "genetic", "marker", "study", "its", "association", "with", "C0871189#ent", "<e2>", "schizophrenia", "."], "h": {"id": "C1709995", "name": "C1709995#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0871189", "name": "C0871189#ent", "pos": [14, 15]}}
{"token": ["Twenty-four-h", "ambulatory", "ECG", "showed", "a", "reduction", "of", "both", "supraventricular", "and", "ventricular", "arrhythmias", "SR", "C0028005#ent", "<e1>", "not", "only", "compared", "to", "placebo", "but", "also", "vs", "C0008294#ent", "<e2>", "."], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0008294", "name": "C0008294#ent", "pos": [23, 24]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "compare", "the", "effect", "of", "slow-release", "(", "SR", ")", "C0028005#ent", "<e1>", ",", "placebo", "and", "C0008294#ent", "<e2>", "on", "hypertension-related", "arrhythmias", "evaluating", "24-h", "ambulatory", "ECG", "."], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0008294", "name": "C0008294#ent", "pos": [20, 21]}}
{"token": ["C2718533#ent", "<e1>", "is", "a", "gonadotropin-releasing", "hormone", "receptor", "antagonist", "C0001641#ent", "<e2>", ")", "with", "rapid", "onset", "of", "action", "suppressing", "gonadotropins", ",", "testosterone", "and", "prostate", "specific", "antigen", "prostate", "cancer"], "h": {"id": "C2718533", "name": "C2718533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [8, 9]}}
{"token": ["In", "these", "experiments", "C0008809#ent", "<e1>", "was", "as", "efficacious", "as", "standard", "regimens", "used", "to", "treat", "C0038160#ent", "<e2>", "humans", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0038160", "name": "C0038160#ent", "pos": [14, 15]}}
{"token": ["Ciprofloxacin", "resistance", "can", "develop", "rapidly", "in", "S.", "aureus", "thus", ",", "C0008809#ent", "<e1>", "appears", "to", "have", "limited", "usefulness", "in", "treating", "C0038160#ent", "<e2>", "colonization", ",", "especially", "those", "due", "to", "MRSA", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0038160", "name": "C0038160#ent", "pos": [19, 20]}}
{"token": ["Despite", "bactericidal", "antagonism", "in", "time-kill", "experiments", ",", "our", "in", "vitro", "studies", "suggest", "several", "possible", "explanations", "for", "the", "observed", "benefits", "in", "patients", "treated", "with", "combination", "of", "C0008809#ent", "<e1>", "and", "rifampin", "for", "C0038160#ent", "<e2>"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [25, 26]}, "relation": "may_treat", "t": {"id": "C0038160", "name": "C0038160#ent", "pos": [30, 31]}}
{"token": ["Sorsby", "fundus", "dystrophy", "C1850938#ent", "<e1>", ")", "is", "a", "rare", ",", "C0730292#ent", "<e2>", "by", "mutations", "in", "the", "tissue", "inhibitor", "metalloproteinases-3", "(", "TIMP3", ")", "gene", "."], "h": {"id": "C1850938", "name": "C1850938#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0730292", "name": "C0730292#ent", "pos": [10, 11]}}
{"token": ["The", "apparent", "C3889265#ent", "<e1>", "value", "for", "C0038880#ent", "<e2>", ",", "taken", "from", "this", "Schild", "plot", ",", "was", "4.6", "."], "h": {"id": "C3889265", "name": "C3889265#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [6, 7]}}
{"token": ["We", "analyzed", "C0036572#ent", "<e1>", "spread", "pattern", "non-GS", "and", "their", "relationship", "with", "the", "epileptic", "syndrome", "C0392514#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0392514", "name": "C0392514#ent", "pos": [14, 15]}}
{"token": ["A", "water-soluble", "analog", "arvanil", ",", "O-2142", ",", "was", "as", "active", "on", "VR1", ",", "much", "less", "active", "on", "C0063517#ent", "<e1>", "and", "CB1", ",", "and", "more", "potent", "on", "C1414512#ent", "<e2>", "."], "h": {"id": "C0063517", "name": "C0063517#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414512", "name": "C1414512#ent", "pos": [26, 27]}}
{"token": ["Binding", "of", "the", "C3539766#ent", "<e1>", "alanine", ",", "to", "Mn(2+)-dependent", "C0017801#ent", "<e2>", "enhancement", "of", "the", "epsilon-AMP", "fluorescence", ",", "from", "which", "a", "dissociation", "constant", "of", "1.5", "mM", "was", "calculated", "for", "the", "inhibitor", "."], "h": {"id": "C3539766", "name": "C3539766#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017801", "name": "C0017801#ent", "pos": [9, 10]}}
{"token": ["Plasma", "nonphospholipid", "levels", "were", "unchanged", "during", "the", "first", "2", "days", ";", "this", "does", "not", "support", "impaired", "secretion", "or", "transportation", "of", "C0017860#ent", "<e1>", "as", "the", "cause", "of", "C2711227#ent", "<e2>", "the", "early", "stages", "choline", "deficiency"], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [26, 27]}}
{"token": ["The", "C1848862#ent", "<e1>", "is", "thought", "to", "result", "from", "acute", "C0242702#ent", "<e2>", "dopamine", "depletion", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242702", "name": "C0242702#ent", "pos": [9, 10]}}
{"token": ["The", "C0041234#ent", "<e1>", "Trypanosoma", "cruzi", "is", "an", "intracellular", "parasite", "which", "expresses", "different", "C0072522#ent", "<e2>", "on", "its", "plasma", "membrane", "various", "stages", "of", "its", "life-cycle", ",", "but", "does", "not", "exhibit", "antigenic", "variation"], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}}
{"token": ["Selective", "C2936550#ent", "<e1>", "be", "tested", "clinically", "as", "C0728960#ent", "<e2>", ",", "particularly", "under", "conditions", "of", "neuropathic", "pain"], "h": {"id": "C2936550", "name": "C2936550#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [7, 8]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "the", "effect", "of", "C0206461#ent", "<e1>", "on", "ulcer", "outcome", "patients", "with", "C0011849#ent", "<e2>", ",", "peripheral", "arterial", "occlusive", "disease", "and", "chronic", "foot", "ulcers"], "h": {"id": "C0206461", "name": "C0206461#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [19, 20]}}
{"token": ["C1639494#ent", "<e1>", ",", "recently", "brought", "into", "the", "C0032453#ent", "<e2>", "treatment", "have", "not", "superseded", "cortico-steroid", "therapy"], "h": {"id": "C1639494", "name": "C1639494#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0032453", "name": "C0032453#ent", "pos": [7, 8]}}
{"token": ["C0745103#ent", "<e1>", "FH", ")", "is", "an", "autosomal", "dominant", "C0025517#ent", "<e2>", "by", "several", "different", "mutations", "in", "the", "low", "density", "lipoprotein", "LDL", ")", "receptor", "gene", "."], "h": {"id": "C0745103", "name": "C0745103#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [8, 9]}}
{"token": ["C0034678#ent", "<e1>", "activation", "in", "C1704799#ent", "<e2>", "may", "be", "detected", "in", "all", "molecular", "subtypes", "of", "C1704799#ent", "<e2>", "and", "denotes", "poor", "prognosis"], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704799", "name": "C1704799#ent", "pos": [4, 5]}}
{"token": ["In", "11", "patients", "C0553548#ent", "<e1>", "an", "incidental", "finding", "in", "surgically", "removed", "C0567085#ent", "<e2>", "and", "C0567085#ent", "<e2>", "adnexal", "tissues", "."], "h": {"id": "C0553548", "name": "C0553548#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [11, 12]}}
{"token": ["C0012963#ent", "<e1>", "also", "produced", "mild", "C0237795#ent", "<e2>", "effects", "which", "were", "potentiated", "by", "beta-adrenoceptor", "blockade", "propranolol", "."], "h": {"id": "C0012963", "name": "C0012963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [5, 6]}}
{"token": ["C0012963#ent", "<e1>", ",", "like", "other", "amines", ",", "induced", "C0237795#ent", "<e2>", "and", "positive", "chronotropic", "effects"], "h": {"id": "C0012963", "name": "C0012963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [8, 9]}}
{"token": ["The", "utility", "of", "the", "mAb-based", "analytic", "system", "was", "examined", "with", "the", "model", "substrates", "C0678133#ent", "<e1>", "(", "paclitaxel", ")", ",", "diazepam", ",", "tolbutamide", ",", "C0012091#ent", "<e2>", ",", "mephenytoin", ",", "and", "imipramine", "."], "h": {"id": "C0678133", "name": "C0678133#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [23, 24]}}
{"token": ["C4225222#ent", "<e1>", "are", "excellent", "drug", "targets", "exemplified", "by", "the", "activity", "of", "C0939537#ent", "<e2>", "in", "BCR-ABL1-positive", "disease", ",", "particularly", "chronic", "myeloid", "leukemia"], "h": {"id": "C4225222", "name": "C4225222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0939537", "name": "C0939537#ent", "pos": [11, 12]}}
{"token": ["After", "improvement", "of", "his", "performance", "status", "he", "received", "combination", "chemotherapy", "of", "cyclophosphamide", ",", "C0014582#ent", "<e1>", ",", "vincristine", "and", "predonisone", "(", "C1413947#ent", "<e2>", "regimen", ")", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413947", "name": "C1413947#ent", "pos": [20, 21]}}
{"token": ["Results", "obtained", "using", "HCHO", "stabilization", "strongly", "indicate", "that", "the", "factors", "detected", "on", "the", "43S/48S", "C0730321#ent", "<e1>", "after", "C3273112#ent", "<e2>", "approximate", "a", "real-time", "in", "vivo", "snapshot", "\"", "of", "the", "43S/48S", "C0730321#ent", "<e1>", "composition", "."], "h": {"id": "C3273112", "name": "C3273112#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0730321", "name": "C0730321#ent", "pos": [14, 15]}}
{"token": ["The", "most", "widely", "used", "retinoids", "include", "topical", "tretinoin", "Retin-A", ")", ",", "adapalene", "(", "Differin", ")", ",", "topical", "tazarotene", "C0723607#ent", "<e1>", ")", ",", "isotretinoin", "(", "Accutane", ")", ",", "and", "C0050559#ent", "<e2>", "(", "Soriatane", ")", "."], "h": {"id": "C0723607", "name": "C0723607#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0050559", "name": "C0050559#ent", "pos": [28, 29]}}
{"token": ["The", "age-related", "increase", "in", "sensitivity", "to", "cardiotoxic", "effects", "has", "already", "been", "described", "for", "C0282210#ent", "<e1>", ",", "can", "therefore", "be", "extended", "to", "C0020223#ent", "<e2>", "and", "minoxidil", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [21, 22]}}
{"token": ["In", "addition", "to", "the", "care", "of", "patients", "with", "C1561643#ent", "<e1>", "the", "public", "treatment", "syphilis", "and", "C0036262#ent", "<e2>", "now", "had", "to", "be", "attended", "to", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036262", "name": "C0036262#ent", "pos": [15, 16]}}
{"token": ["A", "direct", "interaction", "of", "the", "two", "proteins", "occurs", "through", "the", "N", "terminus", "of", "C1335812#ent", "<e1>", "and", "the", "plant", "homeodomain", "C1414123#ent", "<e2>", "."], "h": {"id": "C1335812", "name": "C1335812#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414123", "name": "C1414123#ent", "pos": [19, 20]}}
{"token": ["C0025229#ent", "<e1>", "be", "considered", "in", "the", "differential", "diagnosis", "a", "C0221423#ent", "<e2>", "children", "who", "are", "susceptible", "to", "infections", "."], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [9, 10]}}
{"token": ["Our", "data", "indicate", "that", "PGE2", "and", "C1537501#ent", "<e1>", "are", "the", "major", "inflammatory", "mediators", "triggering", "the", "release", "of", "C1335796#ent", "<e2>", "from", "the", "perivascular", "CGRP-containing", "nerve", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335796", "name": "C1335796#ent", "pos": [17, 18]}}
{"token": ["Markers", "mentioned", "for", "C1136084#ent", "<e1>", "kappa", ",", "lambda", ",", "CD38", ",", "CD45", ",", "C1334863#ent", "<e2>", ",", "CD19", ",", "CD20", ",", "CD138", ",", "and", "heavy", "chains"], "h": {"id": "C1136084", "name": "C1136084#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [13, 14]}}
{"token": ["The", "32P-labeling", "of", "the", "C0751465#ent", "<e1>", "increased", "by", "2", "-", "3-fold", "when", "C0282625#ent", "<e2>", "included", "in", "the", "phosphorylation", "reaction"], "h": {"id": "C0751465", "name": "C0751465#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [12, 13]}}
{"token": ["In", "advanced", "C0001342#ent", "<e1>", ",", "a", "strong", "reaction", "for", "C3810569#ent", "<e2>", "was", "localised", "to", "the", "pocket", "epithelium"], "h": {"id": "C0001342", "name": "C0001342#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [9, 10]}}
{"token": ["Semi-quantitative", "RT-PCR", "analysis", "indicated", "that", "C1426906#ent", "<e1>", "mRNA", "is", "developmentally", "regulated", "in", "the", "C0032002#ent", "<e2>", "."], "h": {"id": "C1426906", "name": "C1426906#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [13, 14]}}
{"token": ["The", "incidence", "and", "magnitude", "of", "false-positive", "serum", "digoxin", "concentrations", "(", "SDCs", ")", "determined", "by", "three", "C0012265#ent", "<e1>", "patients", "with", "C0023895#ent", "<e2>", "studied", "."], "h": {"id": "C0012265", "name": "C0012265#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [19, 20]}}
{"token": ["Overall", ",", "data", "from", "several", "clinical", "studies", "that", "their", "hypoglycaemic", "efficacy", "is", "slightly", "less", "than", "sulphonylureas", "and", "C0770893#ent", "<e1>", "but", "greater", "than", "acarbose", "and", "the", "C3537178#ent", "<e2>", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3537178", "name": "C3537178#ent", "pos": [25, 26]}}
{"token": ["These", "findings", "indicate", "that", "C0673456#ent", "<e1>", "has", "a", "weaker", "cardiovascular", "depressant", "potency", "than", "C0016986#ent", "<e2>", "."], "h": {"id": "C0673456", "name": "C0673456#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016986", "name": "C0016986#ent", "pos": [13, 14]}}
{"token": ["The", "vasorelaxant", "potency", "of", "C0673456#ent", "<e1>", "was", "244", "times", "weaker", "than", "that", "of", "C0016986#ent", "<e2>", "."], "h": {"id": "C0673456", "name": "C0673456#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016986", "name": "C0016986#ent", "pos": [13, 14]}}
{"token": ["Strikingly", ",", "this", "sequence", "bears", "no", "obvious", "similarity", "to", "the", "sequence", "bound", "by", "C1415470#ent", "<e1>", "at", "UAS1", "of", "the", "C1413845#ent", "<e2>"], "h": {"id": "C1415470", "name": "C1415470#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413845", "name": "C1413845#ent", "pos": [19, 20]}}
{"token": ["Stimuli", "that", "increase", "C0030306#ent", "<e1>", "i.e.", "surgery", ",", "trauma", ",", "or", "C0243026#ent", "<e2>", "may", "promote", "intravascular", "thrombosis", "the", "inhibition", "of", "antithrombin", "III", "the", "blood-endothelial", "cell", "interface", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [11, 12]}}
{"token": ["C0298973#ent", "<e1>", "ATM", ")", "is", "a", "C2713509#ent", "<e2>", "PIKK", ")", "associated", "with", "DNA", "double-strand", "break", "DSB", ")", "repair", "and", "cell", "cycle", "control"], "h": {"id": "C0298973", "name": "C0298973#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [6, 7]}}
{"token": ["The", "protein", "kinase", "C", "C3539645#ent", "<e1>", ")", "inhibitor", "chelerythrine", "mimics", "C0245514#ent", "<e2>", "effects", ",", "whereas", "phorbol", "ester", "reverses", "the", "effects", "on", "ammoniagenesis", "consistent", "with", "C0245514#ent", "<e2>", "negatively", "regulating", "the", "DAG/PKC/ERK", "pathway", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0245514", "name": "C0245514#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "indicate", "that", "MOR", "C0243192#ent", "<e1>", "could", "modulate", "the", "activity", "of", "GABA", "neurons", "in", "the", "C1725733#ent", "<e2>", "via", "receptors", "located", "mainly", "at", "extrasynaptic", "sites", "on", "dendritic", "plasma", "membranes"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1725733", "name": "C1725733#ent", "pos": [16, 17]}}
{"token": ["The", "intracranial", "self-administration", "ICSA", ")", "of", "D1", "and", "C0243192#ent", "<e1>", "used", "to", "determine", "whether", "activating", "D1", "and/or", "D2", "receptors", "the", "C1725733#ent", "<e2>", "of", "Wistar", "rats", "reinforcing", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1725733", "name": "C1725733#ent", "pos": [20, 21]}}
{"token": ["Pigeons", "from", "the", "C1420085#ent", "<e1>", "line", "had", "significantly", "higher", "systolic", "blood", "pressures", "the", "C1414322#ent", "<e2>", "line", "at", "ages", "1", "through", "6", "months", "."], "h": {"id": "C1420085", "name": "C1420085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414322", "name": "C1414322#ent", "pos": [13, 14]}}
{"token": ["The", "risk", "of", "C0521542#ent", "<e1>", "these", "subjects", "with", "C0020445#ent", "<e2>", "at", "least", "20", "times", "higher", "than", "in", "the", "general", "population"], "h": {"id": "C0521542", "name": "C0521542#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [8, 9]}}
{"token": ["Rats", "fed", "a", "vitamin", "A-deficient", "diet", "for", "10", "weeks", "exhibited", "a", "decreased", "expression", "of", "C1366536#ent", "<e1>", ",", "RXR", "and", "C0040961#ent", "<e2>", "mRNA", "and", "of", "RC3", "mRNA", "and", "proteins", "."], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [19, 20]}}
{"token": ["C1414039#ent", "<e1>", "was", "originally", "identified", "as", "a", "C0079429#ent", "<e2>", "whose", "expression", "was", "down-regulated", "in", "regions", "of", "the", "brain", "associated", "with", "Alzheimer's", "disease"], "h": {"id": "C1414039", "name": "C1414039#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [7, 8]}}
{"token": ["C1414039#ent", "<e1>", "(", "KIAA0018", ")", "gene", "is", "the", "seventh", "most", "highlyexpressed", "C0079429#ent", "<e2>", "in", "the", "adult", "adrenal", "gland", "along", "with", "genes", "coding", "for", "steroidogenic", "enzymes", "."], "h": {"id": "C1414039", "name": "C1414039#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["C3538744#ent", "<e1>", "is", "a", "member", "of", "the", "C0919458#ent", "<e2>", "is", "expressed", "on", "the", "basolateral", "membrane", "hepatocytes", "and", "undergoes", "adaptive", "upregulation", "response", "to", "cholestatic", "injury", "or", "bile", "acid", "feeding", "."], "h": {"id": "C3538744", "name": "C3538744#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919458", "name": "C0919458#ent", "pos": [7, 8]}}
{"token": ["To", "assess", "the", "relationship", "between", "C0014544#ent", "<e1>", "and", "infection", "with", "C3488382#ent", "<e2>", "Toxocara", "canis", "a", "case-control", "study", "in", "the", "rural", "area", "the", "Cordillera", "Province", ",", "Bolivia", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3488382", "name": "C3488382#ent", "pos": [10, 11]}}
{"token": ["Strong", "C0752312#ent", "<e1>", "immunoreactivity", "was", "also", "present", "at", "the", "postsynaptic", "domain", "all", "human", "C0751950#ent", "<e2>"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [13, 14]}}
{"token": ["CF", "cells", "not", "exhibit", "an", "apical", "membrane", "C1704697#ent", "<e1>", ",", "nor", "can", "a", "C1704697#ent", "<e1>", "be", "activated", "by", "C0022245#ent", "<e1>", "."], "h": {"id": "C1704697", "name": "C1704697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [18, 19]}}
{"token": ["At", "V", "=", "-100", "mV", "where", "the", "voltage-dependent", "chloride", "conductance", "mitochondria-rich", "(", "MR", ")", "cells", "was", "already", "fully", "activated", ",", "C1704697#ent", "<e1>", "was", "unaffected", "by", "cyclic", "AMP", "C0022245#ent", "<e2>", "."], "h": {"id": "C1704697", "name": "C1704697#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [27, 28]}}
{"token": ["Since", "cardiac", "output", "heart", "rate", "not", "altered", "during", "the", "marked", "systemic", "vasodepressor", "response", "to", "ADM", ",", "activation", "of", "the", "ADM", "C3537240#ent", "<e1>", "mechanism", "may", "represent", "a", "therapeutic", "alternative", "in", "the", "clinical", "management", "C0848548#ent", "<e2>"], "h": {"id": "C3537240", "name": "C3537240#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0848548", "name": "C0848548#ent", "pos": [32, 33]}}
{"token": ["Mutations", "in", "human", "WRN", "(", "also", "known", "as", "C0388246#ent", "<e1>", "give", "rise", "to", "a", "rare", "autosomal", "recessive", "genetic", "disorder", "C1337007#ent", "<e2>", "WS", ")", "."], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1337007", "name": "C1337007#ent", "pos": [19, 20]}}
{"token": ["Far", "Western", "blotting", "two-hybrid", "analyses", "a", "direct", "interaction", "of", "p110", "with", "C1705610#ent", "<e1>", ",", "p135", "with", "p33", ",", "and", "p33", "with", "C0058985#ent", "<e2>", "."], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0058985", "name": "C0058985#ent", "pos": [21, 22]}}
{"token": ["We", "compare", "the", "safety", "and", "effectiveness", "of", "twice-daily", "topical", "application", "during", "1", "week", "of", "0.6", "%", "and", "1", "%", "ajoene", "and", "1", "%", "C0076110#ent", "<e1>", "in", "the", "treatment", "of", "C0040259#ent", "<e2>"], "h": {"id": "C0076110", "name": "C0076110#ent", "pos": [23, 24]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [29, 30]}}
{"token": ["C0076110#ent", "<e1>", "(", "presently", "used", "as", "a", "1-week", "topical", "treatment", "C0040259#ent", "<e2>", "is", "now", "available", "in", "a", "novel", "topical", "solution", "film-forming", "solution", "--", "FFS", ")", ",", "developed", "to", "allow", "single", "application", "."], "h": {"id": "C0076110", "name": "C0076110#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [10, 11]}}
{"token": ["In", "order", "to", "perform", "a", "preclinical", "evaluation", "of", "effectiveness", "of", "C0076110#ent", "<e1>", "TBF", ")", "in", "C0040259#ent", "<e2>", "an", "animal", "model", "produced", "using", "guinea", "pigs", "experimentally", "infecting", "the", "plantar", "skin", "Trichophyton", "mentagrophytes"], "h": {"id": "C0076110", "name": "C0076110#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [15, 16]}}
{"token": ["C0054047#ent", "<e1>", ",", "but", "not", "C1415740#ent", "<e2>", ",", "accelerates", "disassembly", "of", "filaments", "diluted", "into", "a", "depolymerizing", "medium"], "h": {"id": "C0054047", "name": "C0054047#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [5, 6]}}
{"token": ["We", "also", "found", "that", "both", "proteins", "reduce", "the", "viscosity", "of", "F-actin", "measured", "with", "high-shear", "and", "low-shear", "viscometers", ",", "with", "C0054047#ent", "<e1>", "effective", "at", "much", "lower", "concentrations", "than", "C1415740#ent", "<e2>", "."], "h": {"id": "C0054047", "name": "C0054047#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415740", "name": "C1415740#ent", "pos": [27, 28]}}
{"token": ["NADH", "and", "NADPH", "accelerate", "the", "'", "in", "vitro", "rate", "of", "proteolysis", "of", "C1414968#ent", "<e1>", "GAPDH", ")", "by", "C0699918#ent", "<e2>", "and", "other", "proteases", ",", "including", "lysosomal", "proteases"], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [17, 18]}}
{"token": ["Two", "biological", "candidate", "genes", "(", "C0038302#ent", "<e1>", "and", "IFIT1", ")", "located", "on", "C0795840#ent", "<e2>", "have", "previously", "been", "implicated", "in", "endometriosis", "and/or", "uterine", "function"], "h": {"id": "C0038302", "name": "C0038302#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0795840", "name": "C0795840#ent", "pos": [12, 13]}}
{"token": ["We", "report", "a", "patient", "who", "developed", "SLE", "during", "the", "course", "of", "C0878555#ent", "<e1>", "DPB", ")", "and", "had", "C0006840#ent", "<e2>", "later", "."], "h": {"id": "C0878555", "name": "C0878555#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [17, 18]}}
{"token": ["The", "above", "findings", "suggest", "that", "stress", "induced", "inhibition", "of", "NK", ",", "C1538265#ent", "<e1>", "and", "CTL", "activities", "partially", "via", "affecting", "NK", "receptors", "C1333877#ent", "<e2>", "and", "perforin", "."], "h": {"id": "C1538265", "name": "C1538265#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333877", "name": "C1333877#ent", "pos": [21, 22]}}
{"token": ["Similarly", ",", "NK", "cell-mediated", "cytotoxic", "activity", "and", "C1333196#ent", "<e1>", "production", "were", "not", "modified", "by", "C0286738#ent", "<e2>", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0286738", "name": "C0286738#ent", "pos": [14, 15]}}
{"token": ["Extra", "potassium", "supplements", ",", "spironolactone", "or", "C0002502#ent", "<e1>", "were", "given", "for", "5", "months", "to", "forty-nine", "patients", "with", "C0018802#ent", "<e2>", "were", "taking", "furosemide", "and", "were", "in", "a", "steady", "state"], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["For", "the", "successful", "clinical", "application", "MR-monitored", "C1337109#ent", "<e1>", ",", "it", "is", "necessary", "to", "relate", "C1417249#ent", "<e2>", "images", "of", "C1337109#ent", "<e1>", "lesions", "to", "the", "actual", "induced", "lesions", "."], "h": {"id": "C1417249", "name": "C1417249#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337109", "name": "C1337109#ent", "pos": [6, 7]}}
{"token": ["Gly300Val", ",", "c.799", "-", "1683_949", "-", "1293del3128", ",", "and", "two", "other", "large", "genomic", "deletions", "exons", "1", "the", "complete", "C0079429#ent", "<e1>", ")", "and", "two", "known", "mutations", "in", "the", "C1417196#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417196", "name": "C1417196#ent", "pos": [27, 28]}}
{"token": ["Here", ",", "we", "report", "that", "the", "C0536847#ent", "<e1>", "promoter", "with", "the", "A", "C1706112#ent", "<e2>", "showed", "higher", "promoter", "activity", "the", "INS-1", "beta-cell", "line", "."], "h": {"id": "C0536847", "name": "C0536847#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [12, 13]}}
{"token": ["We", "therefore", "conclude", "that", "C0060657#ent", "<e1>", "protects", "significantly", "better", "against", "the", "C0719022#ent", "<e2>", "challenge", "with", "histamine", "than", "does", "salbutamol", "."], "h": {"id": "C0060657", "name": "C0060657#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "C0006812#ent", "<e1>", "appear", "to", "be", "C0010858#ent", "<e2>", "for", "non-tumorigenic", ",", "but", "cytotoxic", "for", "tumorigenic", "cells", ",", "an", "important", "finding", "from", "viewpoints", "of", "cell", "biology", "pharmacology", "and", "cancer", "chemotherapy"], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [8, 9]}}
{"token": ["A", "trend", "for", "pain", "relief", "noted", "in", "the", "subgroup", "that", "received", "C0011777#ent", "<e1>", "with", "a", "diagnosis", "of", "C0949690#ent", "<e2>", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [17, 18]}}
{"token": ["At", "an", "appropriate", "dose", "C0913246#ent", "<e1>", "was", "as", "effective", "as", "NSAIDs", "in", "osteoarthritis", "and", "C0003873#ent", "<e2>"], "h": {"id": "C0913246", "name": "C0913246#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "C0206800#ent", "<e1>", "improves", "walking", "capacity", "patients", "with", "C0085096#ent", "<e2>", "probably", "acting", "through", "a", "metabolic", "mechanism", "."], "h": {"id": "C0206800", "name": "C0206800#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [10, 11]}}
{"token": ["A", "decreased", "number", "is", "measured", "in", "C0151744#ent", "<e1>", "in", "dilated", "cardiomyopathy", "in", "C0020676#ent", "<e2>", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [12, 13]}}
{"token": ["C0044707#ent", "<e1>", "protein", "was", "increased", "1.6-fold", "by", "C0002502#ent", "<e2>", "."], "h": {"id": "C0044707", "name": "C0044707#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [7, 8]}}
{"token": ["This", "C0027868#ent", "<e1>", "resistant", "to", "steroid", "therapy", "dramatically", "improved", "with", "C0010583#ent", "<e2>", "treatment", "."], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [10, 11]}}
{"token": ["C1825552#ent", "<e1>", "has", "been", "classified", "as", "a", "secreted", "C0030946#ent", "<e2>", "involved", "in", "TGFbeta", "signaling", "but", "recent", "work", "has", "shown", "C1825552#ent", "<e1>", "to", "be", "a", "tumor", "suppressor"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1825552", "name": "C1825552#ent", "pos": [0, 1]}}
{"token": ["Two", "of", "the", "interacting", "C1333677#ent", "<e1>", "identified", "as", "the", "C1418577#ent", "<e2>", "phosphatidylinositol", "3-kinase", "the", "GTPase-activating", "protein", "p21ras", "."], "h": {"id": "C1333677", "name": "C1333677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418577", "name": "C1418577#ent", "pos": [9, 10]}}
{"token": ["We", "identified", "and", "tested", "C0012544#ent", "<e1>", "as", "inhibitors", "of", "a", "C0162572#ent", "<e2>", "molecular", "target"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162572", "name": "C0162572#ent", "pos": [10, 11]}}
{"token": ["Perturbations", "in", "intracellular", "C2936886#ent", "<e1>", "can", "activate", "proteolytic", "C3540790#ent", "<e2>", "including", "calpain", ",", "leading", "to", "deleterious", "effects", "axons", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [8, 9]}}
{"token": ["The", "duration", "of", "follow-up", "at", "family", "health", "centers", "C1414833#ent", "<e1>", ")", "was", "determined", "from", "a", "national", "prevalence", "study", "of", "C3266262#ent", "<e2>", "illnesses", "causing", "disability", "in", "preschool", "children", "."], "h": {"id": "C1414833", "name": "C1414833#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3266262", "name": "C3266262#ent", "pos": [19, 20]}}
{"token": ["The", "noncoding", "portions", "of", "the", "two", "C1414402#ent", "<e1>", "adjacent", "to", "the", "initiation", "and", "termination", "codons", "approximately", "70", "%", "C1334043#ent", "<e2>", "and", "contain", "sequences", "thought", "to", "be", "involved", "in", "the", "synthesis", "and", "processing", "messenger", "RNA"], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["Chromatin", "immunoprecipitations", "a", "direct", "association", "of", "Lsh", "with", "the", "5", "'", "C1426317#ent", "<e1>", "at", "the", "C1366618#ent", "<e2>", "promoter", ",", "but", "not", "with", "Kv", "DMR1", "or", "other", "imprinted", "loci"], "h": {"id": "C1426317", "name": "C1426317#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366618", "name": "C1366618#ent", "pos": [15, 16]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "investigate", "the", "pattern", "of", "serum", "non-esterified", "fatty", "acid", "C1417875#ent", "<e1>", ")", "fraction", "in", "association", "with", "C0004153#ent", "<e2>", "development", "."], "h": {"id": "C1417875", "name": "C1417875#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [22, 23]}}
{"token": ["Because", "ET-1", "and", "its", "receptor", "are", "involved", "in", "atherogenesis", ",", "our", "findings", "suggested", "that", "increase", "in", "circulating", "C1417875#ent", "<e1>", "may", "contribute", "to", "the", "acceleration", "of", "C0004153#ent", "<e2>", "in", "diabetic", "patients", "."], "h": {"id": "C1417875", "name": "C1417875#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [25, 26]}}
{"token": ["C0038633#ent", "<e1>", "reduces", "the", "C0032285#ent", "<e2>", "rate", "compared", "to", "H2-blockers", "or", "antacids", "by", "not", "interfering", "with", "the", "gastric", "barrier"], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [4, 5]}}
{"token": ["Patients", "with", "heart", "failure", "C1538440#ent", "<e1>", ")", "often", "suffer", "from", "C0037315#ent", "<e2>", "SRBD", ")", "like", "Cheyne-Stokes", "respiration", "CSR", ")", "."], "h": {"id": "C1538440", "name": "C1538440#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037315", "name": "C0037315#ent", "pos": [10, 11]}}
{"token": ["W", "and", "Y", "motifs", "present", "in", "at", "least", "half", "of", "the", "identified", "oomycete", "RXLR-dEER", "effector", "candidates", ",", "and", "we", "show", "that", "three", "of", "these", "C1332838#ent", "<e1>", "also", "suppress", "C1418296#ent", "<e2>", "in", "soybean", "."], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1418296", "name": "C1418296#ent", "pos": [28, 29]}}
{"token": ["These", "C0036572#ent", "<e1>", "and", "electroencephalographic", "patterns", "that", "C0162635#ent", "<e2>", "in", "most", "of", "the", "patients", "as", "a", "nonprogressive", ",", "age-dependent", "myoclonic", "encephalopathy", "a", "prominent", "occipital", "involvement", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0162635", "name": "C0162635#ent", "pos": [7, 8]}}
{"token": ["This", "novel", "p122-RhoGAP", "binds", "to", "C1870412#ent", "<e1>", "activates", "the", "phosphatidylinositol", "4,5-bisphosphate", "PIP2", ")", "C0033993#ent", "<e2>", "activity", "of", "C1870412#ent", "<e1>"], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1870412", "name": "C1870412#ent", "pos": [5, 6]}}
{"token": ["In", "the", "HS", "group", ",", "increased", "C0812281#ent", "<e1>", "and", "decreased", "NO", "were", "observed", "in", "C0268731#ent", "<e2>", "in", "vivo"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [14, 15]}}
{"token": ["NGF", "increased", "the", "DNA", "binding", "activity", "C0919496#ent", "<e1>", ",", "which", "was", "suppressed", "by", "inhibitors", "of", "C0919487#ent", "<e2>", "and", "PI3K"], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0919487", "name": "C0919487#ent", "pos": [15, 16]}}
{"token": ["Previously", "we", "determined", "the", "cleavage", "site", "C2826592#ent", "<e1>", "targeted", "by", "the", "C0030940#ent", "<e2>", "human", "coxsackievirus", "serotype", "B4", "human", "rhinovirus", "serotype", "2", "highly", "purified", "eIF4F", "and", "recombinant", "proteases"], "h": {"id": "C2826592", "name": "C2826592#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [11, 12]}}
{"token": ["These", "results", "demonstrate", "that", "PBZ", "modulates", "the", "chemokinetic", "effect", "of", "C1333574#ent", "<e1>", "on", "PMNs", "and", "thus", "C2712370#ent", "<e2>", "oriented", "PMN", "migration", "."], "h": {"id": "C1333574", "name": "C1333574#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [16, 17]}}
{"token": ["Different", "from", "TOP2", "poisons", "and", "other", "DNA-damaging", "agents", ",", "C0123145#ent", "<e1>", "did", "not", "induce", "proteasomal", "degradation", "the", "large", "subunit", "of", "C0035680#ent", "<e2>"], "h": {"id": "C0123145", "name": "C0123145#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [20, 21]}}
{"token": ["In", "general", ",", "triphenyl", "phosphate", "TPP", ")", "and", "diethyl", "maleate", "C1833296#ent", "<e1>", ")", "showed", "low", "toxicities", "to", "six", "herbivorous", "C0032064#ent", "<e2>", "insects", ",", "four", "ladybirds", "and", "eight", "parasitoids", "."], "h": {"id": "C1833296", "name": "C1833296#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032064", "name": "C0032064#ent", "pos": [19, 20]}}
{"token": ["We", "have", "examined", "the", "effects", "of", "thiopental", ",", "C0025668#ent", "<e1>", ",", "propofol", ",", "etomidate", "and", "ketamine", "on", "C0751785#ent", "<e2>", "chemotaxis", "in", "vitro"], "h": {"id": "C0025668", "name": "C0025668#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751785", "name": "C0751785#ent", "pos": [17, 18]}}
{"token": ["We", "analyzed", "the", "relapse", "rates", "of", "hyperthyroidism", "and", "prevalence", "rates", "of", "C3665349#ent", "<e1>", "after", "partial", "thyroidectomy", "radio-iodine", "therapy", "in", "patients", "with", "Graves'", "disease", "C0154143#ent", "<e2>"], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0154143", "name": "C0154143#ent", "pos": [23, 24]}}
{"token": ["In", "contrast", ",", "in", "patients", "with", "Graves'", "disease", "C3665349#ent", "<e1>", "occurred", "more", "often", "after", "radio-iodine", "therapy", "than", "in", "the", "C0154143#ent", "<e2>", "group", "(", "P", "less", "than", "0.02", ")", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0154143", "name": "C0154143#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "the", "effects", "of", "retrograde", "coronary", "sinus", "infusion", "of", "cardioplegic", "solution", "C0242231#ent", "<e1>", "created", "in", "the", "canine", "preparation", "by", "occluding", "the", "left", "circumflex", "artery", "C2987137#ent", "<e2>", ")", "during", "cardioplegic", "arrest"], "h": {"id": "C0242231", "name": "C0242231#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987137", "name": "C2987137#ent", "pos": [25, 26]}}
{"token": ["MSC", "administration", "immediately", "after", "exposure", "to", "C1337098#ent", "<e1>", "also", "significantly", "reduced", "the", "degree", "of", "BLM-induced", "inflammation", "and", "C0009325#ent", "<e2>", "deposition", "within", "lung", "tissue"], "h": {"id": "C1337098", "name": "C1337098#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [17, 18]}}
{"token": ["Lung", "pathology", "days", "after", "C1337098#ent", "<e1>", "challenge", "revealed", "significant", "fibrotic", "changes", "with", "increased", "C0009325#ent", "<e2>", "content", ",", "which", "was", "attenuated", "in", "IL-6(-/-", ")", "mice", "."], "h": {"id": "C1337098", "name": "C1337098#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [13, 14]}}
{"token": ["The", "duration", "of", "the", "somatic", "action", "recorded", "from", "cultured", "sensory", "neurons", "is", "known", "to", "be", "decreased", "by", "C1418457#ent", "<e1>", "and", "is", "prolonged", "by", "C0006931#ent", "<e2>", "."], "h": {"id": "C1418457", "name": "C1418457#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [23, 24]}}
{"token": ["The", "neuromuscular", "diseases", "of", "8", "with", "multiple", "sclerosis", "9", "with", "amyotrophic", "lateral", "sclerosis", "8", "with", "C0017551#ent", "<e1>", "11", "myopathies", ",", "and", "10", "suffering", "from", "miscellaneous", "C0027765#ent", "<e2>"], "h": {"id": "C0017551", "name": "C0017551#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [25, 26]}}
{"token": ["The", "results", "indicate", "that", "CYP1", "family", "members", "inducible", "in", "these", "cells", "by", "polycyclic", "aromatic", "hydrocarbon", "PAH", ")", "inducers", ",", "and", "that", "C1413882#ent", "<e1>", ",", "but", "not", "CYP3A4", ",", "is", "present", "C0907533#ent", "<e2>", "."], "h": {"id": "C1413882", "name": "C1413882#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [30, 31]}}
{"token": ["Within", "the", "complex", ",", "donor", "DNA", "is", "relatively", "insensitive", "to", "C0950398#ent", "<e1>", "can", "regain", "its", "sensitivity", "by", "treatment", "with", "C0070570#ent", "<e2>", "."], "h": {"id": "C0950398", "name": "C0950398#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0070570", "name": "C0070570#ent", "pos": [19, 20]}}
{"token": ["The", "catalytic", "mechanism", "structure", "of", "human", "C1453952#ent", "<e1>", "isolated", "from", "human", "post-heparin", "plasma", "and", "the", "effect", "of", "C0041236#ent", "<e2>", "treatment", "on", "the", "lipase", "and", "esterase", "activities", "the", "enzyme", "were", "examined", "."], "h": {"id": "C1453952", "name": "C1453952#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "C0026896#ent", "<e1>", "to", "the", "department", "of", "otolaryngology", "with", "C0011168#ent", "<e2>", "two", "separate", "occasions", "over", "a", "one-year", "period", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [13, 14]}}
{"token": ["On", "an", "individual", "patient", "basis", ",", "however", ",", "the", "ability", "of", "even", "C1335057#ent", "<e1>", "to", "predict", "C0059037#ent", "<e2>", "was", "poor", "."], "h": {"id": "C1335057", "name": "C1335057#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [16, 17]}}
{"token": ["C1335057#ent", "<e1>", "also", "tended", "to", "correlate", "better", "with", "C0059037#ent", "<e2>", "than", "the", "other", "noninvasive", "measurements"], "h": {"id": "C1335057", "name": "C1335057#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "C3539645#ent", "<e1>", "may", "regulate", "both", "C1538681#ent", "<e2>", "release", "and", "glycosylation", "and", "may", "be", "important", "in", "estrogen", "modulation", "C1538681#ent", "<e2>", "release", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1538681", "name": "C1538681#ent", "pos": [9, 10]}}
{"token": ["We", "studied", "the", "effects", "of", "protein", "kinase", "C", "C3539645#ent", "<e1>", ")", "activators", "on", "C1538681#ent", "<e2>", "glycosylation", "and", "release", "and", "the", "effect", "of", "17", "beta-estradiol", "on", "C3539645#ent", "<e1>", "activator-induced", "C1538681#ent", "<e2>", "release", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538681", "name": "C1538681#ent", "pos": [13, 14]}}
{"token": ["Inhibitors", "of", "C3539645#ent", "<e1>", "had", "either", "no", "effect", "C1538681#ent", "<e2>", "release", "(", "1-(5-isoquinolinesulphonyl)-2-methylpiperazine", "hydrochloride", ")", "or", "they", "augmented", "LHRH-induced", "gonadotrophin", "release", "(", "polymyxin", "B", "8-(N", ",", "N-diethylamino", ")", "octyl-3,4,5-trimethoxybenzoate", ")", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1538681", "name": "C1538681#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "describe", "the", "crystal", "structure", "Cbl-N", ",", "both", "alone", "and", "in", "complex", "with", "a", "C1519061#ent", "<e1>", "that", "represents", "its", "binding", "site", "C1527940#ent", "<e2>", "."], "h": {"id": "C1519061", "name": "C1519061#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1527940", "name": "C1527940#ent", "pos": [22, 23]}}
{"token": ["Leukotriene", "receptor", "antagonists", "as", "C0380447#ent", "<e1>", "have", "demonstrated", "efficacy", "in", "chronic", "asthma", "but", "their", "efficacy", "in", "C0004096#ent", "<e2>", "unknown", "."], "h": {"id": "C0380447", "name": "C0380447#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["None", "of", "the", "four", "C0524947#ent", "<e1>", "to", "date", "contain", "C1412821#ent", "<e2>", "identities", "to", "either", "O-acetyl-L-serine", "sulfhydrylase", "OASS", ")", "or", "homocysteine", "synthase", "the", "only", "sulfur-fixing", "enzymes", "known", "in", "nature", "."], "h": {"id": "C0524947", "name": "C0524947#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [9, 10]}}
{"token": ["An", "unusual", "cause", "of", "C0520679#ent", "<e1>", "a", "boy", "with", "C1366464#ent", "<e2>", "was", "urgently", "intubated", "during", "the", "night", "because", "of", "suspected", "bleeding", "into", "the", "airway", "is", "analysed", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366464", "name": "C1366464#ent", "pos": [9, 10]}}
{"token": ["Several", "distinct", "mutations", "in", "exon", "2", "C0019562#ent", "<e1>", "disrupt", "binding", "of", "C0299505#ent", "<e2>", "to", "TBP-1", "."], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [6, 7]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0299505", "name": "C0299505#ent", "pos": [11, 12]}}
{"token": ["A", "second", "patient", "developed", "nongranulomatous", "anterior", "uveitis", "by", "C0750046#ent", "<e1>", "concurrent", "choroiditis", ",", "C0339546#ent", "<e2>", "and", "cystoid", "macular", "edema", "case", "2", "."], "h": {"id": "C0750046", "name": "C0750046#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0339546", "name": "C0339546#ent", "pos": [13, 14]}}
{"token": ["To", "test", "if", "PB-DOPA", "was", "also", "able", "to", "inhibit", "LDL", "oxidation", "DOPA", "residues", "were", "generated", "enzymatically", "in", "the", "model", "C0030956#ent", "<e1>", "insulin", "and", "C0077599#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0077599", "name": "C0077599#ent", "pos": [23, 24]}}
{"token": ["C1335809#ent", "<e1>", "mRNA", "was", "not", "detectable", "in", "total", "RNA", "isolated", "from", "purified", "rat", "platelets", ",", "suggesting", "that", "the", "increased", "levels", "of", "C1335809#ent", "<e1>", "mRNA", "were", "the", "result", "of", "upregulation", "of", "C1414260#ent", "<e1>", "."], "h": {"id": "C1335809", "name": "C1335809#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414260", "name": "C1414260#ent", "pos": [30, 31]}}
{"token": ["Transcription", "of", "POX1", ",", "the", "gene", "encoding", "C0541394#ent", "<e1>", "the", "yeast", "Saccharomyces", "cerevisiae", "is", "controlled", "by", "the", "C0524928#ent", "<e2>", "source", "given", "for", "cell", "growth"], "h": {"id": "C0541394", "name": "C0541394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [17, 18]}}
{"token": ["Two", "rheumatic", "conditions", "where", "C0034734#ent", "<e1>", "phenomenon", "occurs", "very", "commonly", "are", "scleroderma", "and", "C1527336#ent", "<e2>"], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [13, 14]}}
{"token": ["The", "core", "1", "C1538973#ent", "<e1>", "minimal", "homology", "with", "conserved", "sequences", "in", "previously", "described", "C1621701#ent", "<e2>", ",", "suggesting", "this", "enzyme", "is", "only", "distantly", "related", "to", "the", "known", "beta3-galactosyltransferase", "family", "."], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1621701", "name": "C1621701#ent", "pos": [13, 14]}}
{"token": ["It", "is", "concluded", "that", ",", "together", "with", "5-HT", ",", "C0014710#ent", "<e1>", "and", "DHE", "are", "the", "most", "potent", "5-HT1C", "C0243192#ent", "<e2>", "reported", "so", "far", "."], "h": {"id": "C0014710", "name": "C0014710#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [18, 19]}}
{"token": ["7", ")", "Based", "on", "the", "above-mentioned", "results", ",", "it", "can", "be", "claimed", "that", "C0009011#ent", "<e1>", "is", "effective", "on", "psychomotor", "seizures", "photogenic", "epilepsy", "the", "secondary", "type", "generalized", "convulsion", "C0022333#ent", "<e2>", ")", "."], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022333", "name": "C0022333#ent", "pos": [27, 28]}}
{"token": ["The", "patient", "had", "a", "past", "history", "of", "C0347950#ent", "<e1>", "induced", "by", "another", "C0003211#ent", "<e2>", "(", "Sedes-G", ")", "given", "per", "os", "."], "h": {"id": "C0347950", "name": "C0347950#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [12, 13]}}
{"token": ["We", "have", "encountered", "five", "hemodialysis", "patients", "who", "had", "received", "enteral", "nutrition", "recovered", "from", "C1260334#ent", "<e1>", "neutropenia", "after", "the", "correction", "of", "C0162429#ent", "<e2>"], "h": {"id": "C1260334", "name": "C1260334#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [20, 21]}}
{"token": ["C0282193#ent", "<e1>", "of", "protamine", "sulfate", "be", "avoided", "since", "unbound", "protamine", "sulfate", "C3536711#ent", "<e2>", "as", "well", "as", "cardiovascular", "effects"], "h": {"id": "C0282193", "name": "C0282193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [11, 12]}}
{"token": ["This", "study", "addressed", "the", "question", "of", "whether", "plasma", "C1418944#ent", "<e1>", "levels", "reflect", "changes", "in", "thrombin", "generation", "patients", "undergoing", "C0003280#ent", "<e2>", "treatment", "."], "h": {"id": "C1418944", "name": "C1418944#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [18, 19]}}
{"token": ["Since", "C1418944#ent", "<e1>", "EPCR", ")", "plays", "a", "role", "in", "the", "C0003280#ent", "<e2>", "in", "placental", "development", ",", "we", "hypothesized", "that", "anti-EPCR", "autoantibodies", "be", "involved", "in", "clinical", "manifestations", "APS", "and", "in", "fetal", "loss"], "h": {"id": "C1418944", "name": "C1418944#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "examine", "the", "influence", "of", "the", "CA", "microsatellite", "polymorphisms", "of", "C1334083#ent", "<e1>", "patients", "with", "C0041323#ent", "<e2>", "(", "TB", ")", "in", "the", "south-eastern", "Chinese", "population", "."], "h": {"id": "C1334083", "name": "C1334083#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "suggest", "that", "C1705543#ent", "<e1>", "a", "central", "role", "in", "the", "C1414672#ent", "<e2>", "of", "the", "disease", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [11, 12]}}
{"token": ["A", "higher", "level", "of", "C0027203#ent", "<e1>", "was", "found", "in", "plants", "which", "had", "been", "C0042798#ent", "<e2>", "prior", "to", "extraction", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042798", "name": "C0042798#ent", "pos": [13, 14]}}
{"token": ["Fluoromethylglyoxal", "in", "the", "presence", "of", "glutathione", "has", "been", "shown", "to", "undergo", "a", "novel", "C0022956#ent", "<e1>", "I-catalyzed", "product", "partitioning", "to", "S-fluorolactoylglutathione", "and", "C0628871#ent", "<e2>", "with", "fluoride", "elimination", "."], "h": {"id": "C0022956", "name": "C0022956#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0628871", "name": "C0628871#ent", "pos": [21, 22]}}
{"token": ["Peptidases", "like", "C1447020#ent", "<e1>", "DP", "IV", "CD26", ")", "and", "aminopeptidase", "N", "APN", ",", "C2986617#ent", "<e2>", ")", "play", "a", "regulatory", "role", "T", "cell", "activation", "and", "represent", "potential", "targets", "for", "the", "treatment", "of", "inflammatory", "disorders"], "h": {"id": "C1447020", "name": "C1447020#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2986617", "name": "C2986617#ent", "pos": [13, 14]}}
{"token": ["The", "case", "of", "a", "patient", "with", "C0282207#ent", "<e1>", "who", "developed", "a", "C0033680#ent", "<e2>", "is", "reported", "."], "h": {"id": "C0282207", "name": "C0282207#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0033680", "name": "C0033680#ent", "pos": [11, 12]}}
{"token": ["C0282207#ent", "<e1>", "a", "rare", "form", "of", "nonhereditary", "gastrointestinal", "polyposis", "associated", "with", "ectodermal", "change", "C0033680#ent", "<e2>"], "h": {"id": "C0282207", "name": "C0282207#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0033680", "name": "C0033680#ent", "pos": [13, 14]}}
{"token": ["Treatment", "with", "C0036075#ent", "<e1>", "also", "attenuated", "IDPN-induced", "depletion", "of", "C1260386#ent", "<e2>", "in", "the", "cerebrum", ",", "suggesting", "its", "free", "radical", "scavenging", "."], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [9, 10]}}
{"token": ["C1412228#ent", "<e1>", "and", "GHRH", "but", "not", "the", "C1332788#ent", "<e2>", "neuralize", "animal", "caps"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332788", "name": "C1332788#ent", "pos": [7, 8]}}
{"token": ["The", "C1412228#ent", "<e1>", "precursor", "protein", "rise", "to", "three", "different", "peptides", ",", "the", "C1332788#ent", "<e2>", "GHRH", ",", "and", "C1412228#ent", "<e1>", ",", "respectively", ",", "and", "here", "we", "dissect", "their", "functional", "properties", "using", "Xenopus", "as", "model", "system"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332788", "name": "C1332788#ent", "pos": [12, 13]}}
{"token": ["Resistance", "is", "attributable", "to", "reduced", "expression", "of", "C0812317#ent", "<e1>", "and", "augmented", "expression", "of", "an", "inhibitory", "small", "isoform", "of", "C3540509#ent", "<e2>", "."], "h": {"id": "C0812317", "name": "C0812317#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540509", "name": "C3540509#ent", "pos": [18, 19]}}
{"token": ["KfoC", "is", "the", "bifunctional", "enzyme", "which", "is", "able", "to", "add", "both", "C4283926#ent", "<e1>", "and", "GlcUA", "on", "C0032594#ent", "<e2>", "termed", "chondroitin", "polymerase"], "h": {"id": "C4283926", "name": "C4283926#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [16, 17]}}
{"token": ["The", "C1454817#ent", "<e1>", "PTP", "epsilon", ")", "is", "a", "C0021699#ent", "<e2>", ",", "receptor-type", "protein", "possesses", "two", "phosphatase", "catalytic", "domains", "of", "transmembranal", "phosphatases"], "h": {"id": "C1454817", "name": "C1454817#ent", "pos": [1, 2]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}}
{"token": ["Activation", "of", "both", "pools", "was", "dependent", "on", "ERK/MAPK", "kinase", "(", "C0169101#ent", "<e1>", ")", "activity", "and", "C0031686#ent", "<e2>", "2A", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [15, 16]}}
{"token": ["Inhibition", "of", "ERK", "with", "the", "C0169101#ent", "<e1>", "inhibitor", "UO126", ",", "the", "C0031686#ent", "<e2>", "MKP-3", ",", "inhibited", "ERK", "activation", ",", "but", "only", "inhibited", "alpha-adrenergic-induced", "NCX1", "upregulation", "by", "30", "%", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [11, 12]}}
{"token": ["Expression", "of", "C1414057#ent", "<e1>", "from", "the", "doubleridge", "allele", "ranges", "from", "35", "%", "of", "C2987364#ent", "<e2>", "level", "in", "E7.0", "head", "to", "<", "1", "%", "of", "wild", "type", "E13.5", "tail", "."], "h": {"id": "C1414057", "name": "C1414057#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}}
{"token": ["The", "results", "obtained", "for", "C0912726#ent", "<e1>", "by", "C1366515#ent", "<e2>", "indicate", "that", "C0912726#ent", "<e1>", "is", "an", "efficient", "scavenger", "of", "H-MG", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0912726", "name": "C0912726#ent", "pos": [4, 5]}}
{"token": ["We", "have", "determined", "that", "CGL-1", "is", "identical", "to", "a", "previously", "identified", "C0017337#ent", "<e1>", "(", "known", "as", "CCPI", ",", "CTLA", "I", "or", "C0061878#ent", "<e2>", "that", "is", "expressed", "only", "in", "activated", "cytotoxic", "T", "lymphocytes"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0061878", "name": "C0061878#ent", "pos": [21, 22]}}
{"token": ["This", "phosphorylation", "increases", "the", "transcriptional", "activity", "MITF", "and", "STAT3", "as", "indicated", "by", "mRNA", "accumulation", "of", "their", "target", "C0017337#ent", "<e1>", "such", "as", "Bcl-2", ",", "C0061878#ent", "<e2>", "and", "c-Myc", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0061878", "name": "C0061878#ent", "pos": [23, 24]}}
{"token": ["We", "have", "reported", "a", "case", "of", "maternal", "death", "associated", "with", "C0864600#ent", "<e1>", "a", "woman", "who", "was", "being", "treated", "with", "immunosuppressive", "drugs", "C4053959#ent", "<e2>"], "h": {"id": "C0864600", "name": "C0864600#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [21, 22]}}
{"token": ["Neutrophil-activating", "peptide-2", "NAP-2", ",", "70", "residues", ";", "also", "called", "C1705594#ent", "<e1>", ")", "binds", "with", "high", "affinity", "to", "the", "C1334126#ent", "<e2>", "neutrophils", "."], "h": {"id": "C1705594", "name": "C1705594#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334126", "name": "C1334126#ent", "pos": [18, 19]}}
{"token": ["The", "development", "of", "C0003392#ent", "<e1>", "or", "other", "antitumor", "agents", "the", "treatment", "of", "metastitic", "C0724624#ent", "<e2>", "should", "prove", "a", "fertile", "field", "for", "investigation", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [13, 14]}}
{"token": ["The", "data", "suggest", "that", "the", "C0028195#ent", "<e1>", "is", "catalyzed", "largely", "by", "a", "C1421531#ent", "<e2>", "partially", "by", "a", "diaphorase", "and", "9-oxoreduction", "by", "a", "carbonyl", "reductase"], "h": {"id": "C0028195", "name": "C0028195#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [12, 13]}}
{"token": ["3-Hydroxy-1-nitropyrene", "bound", "extensively", "to", "DNA", "upon", "C0028195#ent", "<e1>", "by", "rat", "liver", "cytosol", "C1421531#ent", "<e2>", "while", "6-", "and", "8-hydroxy-1-nitropyrene", "bound", "only", "slightly", "."], "h": {"id": "C0028195", "name": "C0028195#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [12, 13]}}
{"token": ["This", "study", "shows", "that", "the", "levels", "of", "various", "CC", "chemokines", "and", "IL-5", "are", "increased", "in", "airways", "of", "C1825840#ent", "<e1>", "patients", ",", "and", "are", "potentially", "involved", "in", "C0014457#ent", "<e2>", "recruitment", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [26, 27]}}
{"token": ["Among", "PGE", "receptor", "EP", ")", "subtype-selective", "agonists", ",", "the", "EP4", "agonist", "C3538902#ent", "<e1>", "-", "329", ",", "markedly", "stimulated", "the", "release", "of", "C1418716#ent", "<e2>", "from", "spinal", "slices", "and", "induced", "allodynia", "."], "h": {"id": "C3538902", "name": "C3538902#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418716", "name": "C1418716#ent", "pos": [21, 22]}}
{"token": ["Mutation", "of", "either", "the", "C1705526#ent", "<e1>", "or", "the", "C0079656#ent", "<e2>", "not", "correlate", "with", "Dukes", "'s", "stage", ",", "tumour", "differentiation", "5", "year", "survival", "rate", "the", "patients", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079656", "name": "C0079656#ent", "pos": [8, 9]}}
{"token": ["There", "has", "been", "much", "interest", "in", "C0023660#ent", "<e1>", ",", "a", "sodium", "channel-blocking", "agent", "used", "clinically", "as", "an", "C3537142#ent", "<e2>", "and", "local", "anesthetic", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3537142", "name": "C3537142#ent", "pos": [17, 18]}}
{"token": ["Trimecaine", "(", "Mesocain", ",", "L\u00e9civa", ")", "an", "analogous", "preparation", "to", "C0023660#ent", "<e1>", "is", "used", "as", "a", "local", "anaesthetic", ",", "C3537142#ent", "<e2>", "and", "spasmolytic", "preparation"], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3537142", "name": "C3537142#ent", "pos": [19, 20]}}
{"token": ["It", "harbors", "multiple", "motifs", "including", "C1528775#ent", "<e1>", ",", "middle", ",", "and", "C0018296#ent", "<e2>", "GED", ")", "domains", "that", "are", "important", "for", "both", "intramolecular", "and", "intermolecular", "interactions", "."], "h": {"id": "C1528775", "name": "C1528775#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [11, 12]}}
{"token": ["C1413430#ent", "<e1>", "does", "not", "bind", "at", "all", "to", "the", "C1539219#ent", "<e2>", "site", "occupied", "by", "the", "HIF-1alpha", "carboxyl-terminal", "helix"], "h": {"id": "C1413430", "name": "C1413430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539219", "name": "C1539219#ent", "pos": [9, 10]}}
{"token": ["We", "describe", "5", "cases", "of", "fulminant", "hepatitis", "by", "the", "HBV", "infection", "in", "patients", "with", "C0018939#ent", "<e1>", "mostly", "malignancies", "(", "C0812385#ent", "<e2>", ",", "lymphoma", ",", "aplastic", "anemia", "AML", ")", "following", "intensive", "chemotherapy"], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [19, 20]}}
{"token": ["Mitogen-activated", "protein", "kinase", "C1370600#ent", "<e1>", ")", "is", "a", "C0072402#ent", "<e2>", "is", "activated", "by", "various", "extracellular", "stimuli", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [8, 9]}}
{"token": ["C2986676#ent", "<e1>", "and", "globulin", "levels", "increase", "as", "HIV", "dis", "progresses", ",", "suggesting", "a", "role", "for", "C2986676#ent", "<e1>", "in", "the", "C0020455#ent", "<e1>", "of", "HIV", "infection"], "h": {"id": "C2986676", "name": "C2986676#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020455", "name": "C0020455#ent", "pos": [19, 20]}}
{"token": ["C0272285#ent", "<e1>", "a", "clinically", "interesting", "model", "of", "C0272286#ent", "<e2>", "thrombus", "formation", "occurs", "much", "more", "frequently", "than", "hemorrhage", ",", "in", "some", "patients", ",", "major", "thrombocytopenia", "is", "observed", "with", "signs", "of", "consumption", "coagulopathy"], "h": {"id": "C0272285", "name": "C0272285#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0272286", "name": "C0272286#ent", "pos": [7, 8]}}
{"token": ["Famotidine", "is", "a", "guanidinothiazole", "derivative", ",", "ranitidine", "contains", "an", "aminomethylfuran", "ring", ",", "and", "C0008783#ent", "<e1>", "has", "an", "C0040263#ent", "<e2>"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040263", "name": "C0040263#ent", "pos": [17, 18]}}
{"token": ["Abdominal-B", "(", "C1705269#ent", "<e1>", ")", "is", "a", "complex", "homeotic", "gene", "a", "difficult", "C1416596#ent", "<e2>", ":", "one", "transcript", "determines", "the", "identity", "of", "four", "different", "abdominal", "segments", "development", "in", "Drosophila", "."], "h": {"id": "C1705269", "name": "C1705269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [12, 13]}}
{"token": ["The", "completeness", "of", "sucrose", "degradation", "by", "endocytosed", "C0053409#ent", "<e1>", "furthermore", "indicates", "that", "all", "lysosomes", "involved", "in", "C3537312#ent", "<e2>", "can", "also", "engage", "in", "endocytosis", "."], "h": {"id": "C0053409", "name": "C0053409#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537312", "name": "C3537312#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "these", "C0017337#ent", "<e1>", "present", "novel", "targets", "for", "gene-based", "therapies", "at", "treating", "C2717961#ent", "<e2>", ",", "especially", "diabetic", "retinopathy", "a", "disease", "currently", "only", "treatable", "with", "LPC", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [14, 15]}}
{"token": ["C1533698#ent", "<e1>", "iNOS", ")", "in", "the", "C0023899#ent", "<e2>", "has", "been", "shown", "to", "increase", "after", "stimulation", "by", "different", "compounds", "."], "h": {"id": "C1533698", "name": "C1533698#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}}
{"token": ["Interestingly", ",", "122", "base", "pairs", "of", "nucleotide", "sequence", "interior", "to", "C1705556#ent", "<e1>", "extensive", "homology", "with", "the", "5", "'", "end", "of", "the", "C1332776#ent", "<e2>", "maize", "mitochondria", ",", "suggesting", "recombination", "between", "the", "two", "genes", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332776", "name": "C1332776#ent", "pos": [21, 22]}}
{"token": ["In", "a", "10", "year", "old", "boy", "with", "infectious", "mononucleosis", "with", "C0022104#ent", "<e1>", "followed", "by", "C0027697#ent", "<e2>", ",", "myocarditis", "and", "Guillain-Barr\u00e9-Syndrome", ",", "all", "the", "complications", "could", "be", "managed", "by", "symptomatic", "treatment", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027697", "name": "C0027697#ent", "pos": [14, 15]}}
{"token": ["Direct", "addition", "of", "BP", "or", "C1414174#ent", "<e1>", "to", "the", "EC", "or", "C1539322#ent", "<e2>", "cultures", "induced", "toxic", "effects", "the", "cells", "."], "h": {"id": "C1414174", "name": "C1414174#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [11, 12]}}
{"token": ["Novel", "findings", "include", "cyclin", "E", "expression", "in", "2", "t(11;14)-negative", "C0026691#ent", "<e1>", "characterized", "by", "a", "cryptic", "t(2;14)(p24;q32", ")", "and", "identification", "of", "C1705027#ent", "<e2>", "as", "a", "new", "lymphoma", "oncogene", "associated", "with", "blastoid", "MCL", "."], "h": {"id": "C0026691", "name": "C0026691#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705027", "name": "C1705027#ent", "pos": [20, 21]}}
{"token": ["To", "evaluate", "the", "efficacy", "and", "safety", "of", "C0053091#ent", "<e1>", "versus", "captopril", "in", "patients", "with", "mild", "or", "moderate", "C0020538#ent", "<e2>", "SAH", ")", "."], "h": {"id": "C0053091", "name": "C0053091#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [17, 18]}}
{"token": ["The", "c2", "allele", "frequencies", "the", "C0919426#ent", "<e1>", "in", "alcoholic", "cirrhosis", "alcoholics", "without", "evidence", "of", "C0023895#ent", "<e2>", "and", "nondrinkers", "were", "0.21", ",", "0.20", ",", "and", "0.20", ",", "respectively", "."], "h": {"id": "C0919426", "name": "C0919426#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [14, 15]}}
{"token": ["C0919426#ent", "<e1>", "mRNA", "and", "protein", "were", "reduced", "in", "patients", "with", "C0023895#ent", "<e2>", "but", "in", "hepatocellular", "disease", "expression", "of", "only", "C0919426#ent", "<e1>", "mRNA", "was", "decreased", "."], "h": {"id": "C0919426", "name": "C0919426#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [10, 11]}}
{"token": ["Association", "of", "a", "C1413212#ent", "<e1>", "Ala/Val", "coding", "polymorphism", "with", "susceptibility", "to", "and", "progression", "of", "C1417325#ent", "<e2>", "recently", "reported", "."], "h": {"id": "C1413212", "name": "C1413212#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [14, 15]}}
{"token": ["Subdiaphragmatic", "vagotomy", "abdominal", "perivagal", "C0023660#ent", "<e1>", "administration", ",", "or", "C0023660#ent", "<e1>", "injection", "into", "the", "nucleus", "tractus", "solitarius", "C1417869#ent", "<e1>", ")", "prevented", "LPS", "hypotension", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [17, 18]}}
{"token": ["C0242350#ent", "<e1>", "continued", "and", "C0021167#ent", "<e2>", "after", "the", "endoscopic", "treatment"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021167", "name": "C0021167#ent", "pos": [4, 5]}}
{"token": ["However", ",", "a", "study", "of", "two", "children", "receiving", "C0010592#ent", "<e1>", "with", "and", "without", "C0069805#ent", "<e2>", "revealed", "no", "significant", "changes", "in", "trough", "blood", "C0010592#ent", "<e1>", "concentrations", "."], "h": {"id": "C0069805", "name": "C0069805#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "we", "review", "the", "results", "of", "clinical", "studies", "the", "last", "10", "years", "using", "C0030899#ent", "<e1>", "to", "treat", "HTLV-1", "associated", "myelopathy", "and", "cutaneous", "and", "C0023281#ent", "<e2>"], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0023281", "name": "C0023281#ent", "pos": [24, 25]}}
{"token": ["By", "means", "of", "causation", "and", "therapy", ",", "C0026936#ent", "<e1>", "permit", "a", "further", "subclassification", "of", "CFS", "and", "C0879468#ent", "<e2>", "."], "h": {"id": "C0026936", "name": "C0026936#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0879468", "name": "C0879468#ent", "pos": [16, 17]}}
{"token": ["Women", "with", "C0041408#ent", "<e1>", "TS", ")", ",", "who", "lack", "a", "complete", "C0678928#ent", "<e2>", ",", "show", "an", "impairment", "in", "remembering", "faces", "in", "classifying", "\"", "fear", "\"", "in", "face", "images", "."], "h": {"id": "C0041408", "name": "C0041408#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [11, 12]}}
{"token": ["In", "3-month", "trials", "we", "paid", "lottery", "C0035579#ent", "<e1>", "during", "daily", "home", "visits", "still-smoking", "C3714496#ent", "<e2>", "patients", "for", "reductions", "in", "breath", "carbon", "monoxide", "CO", ")", ",", "a", "measure", "of", "smoke", "intake"], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3714496", "name": "C3714496#ent", "pos": [13, 14]}}
{"token": ["The", "major", "reason", "for", "the", "lack", "of", "progress", "is", "the", "relative", "lack", "of", "animal", "models", "reproduce", "the", "deleterious", "effects", "ethanol", "on", "the", "C0771711#ent", "<e1>", "that", "are", "observed", "in", "C0012634#ent", "<e2>"], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [28, 29]}}
{"token": ["The", "ascomycete", "Hypocrea", "jecorina", "(", "Trichoderma", "reesei", ",", "an", "industrial", "producer", "C1260229#ent", "<e1>", "and", "hemicellulases", ",", "can", "efficiently", "degrade", "plant", "C0032594#ent", "<e2>", "."], "h": {"id": "C1260229", "name": "C1260229#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [20, 21]}}
{"token": ["Over", "the", "years", ",", "several", "theories", "have", "been", "presented", "regarding", "the", "pathogenesis", "of", "vesicoureteral", "reflux", "C0042580#ent", "<e1>", ")", "in", "children", "without", "C0752235#ent", "<e2>", "posterior", "urethral", "valves"], "h": {"id": "C0042580", "name": "C0042580#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [21, 22]}}
{"token": ["This", "C0021699#ent", "<e1>", "a", "tight", "intermolecular", "complex", "its", "cognate", "transducer", "protein", "C3540561#ent", "<e2>", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540561", "name": "C3540561#ent", "pos": [11, 12]}}
{"token": ["In", "this", "work", ",", "the", "structural", "changes", "in", "a", "fusion", "complex", "consisting", "of", "SRII", "and", "the", "two", "C0021699#ent", "<e1>", "TM1", "and", "TM2", ")", "of", "C3540561#ent", "<e2>", "were", "investigated", "by", "time-resolved", "Fourier", "transform", "infrared", "difference", "spectroscopy"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3540561", "name": "C3540561#ent", "pos": [24, 25]}}
{"token": ["Leucine-zipper", "protein", "kinase/dual", "leucine", "zipper", "bearing", "C0170168#ent", "<e1>", "kinase", "is", "a", "recently", "described", "protein", "serine/threonine", "kinase", "belongs", "to", "the", "C1431040#ent", "<e2>"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1431040", "name": "C1431040#ent", "pos": [19, 20]}}
{"token": ["Exogenous", "expression", "of", "C1822710#ent", "<e1>", "in", "cultured", "cells", "increased", "C1364818#ent", "<e2>", "alpha-secretase", "cleavage", "4-fold", "but", "surprisingly", "had", "little", "effect", "on", "beta-secretase", "cleavage"], "h": {"id": "C1822710", "name": "C1822710#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [9, 10]}}
{"token": ["After", "the", "report", "of", "promising", "results", "with", "troglitazone", ",", "large", "prospective", "studies", "ongoing", "to", "test", "the", "efficacy", "of", "rosiglitazone", "and", "C0872972#ent", "<e1>", "in", "such", "an", "indication", ",", "two", "insulinsensitizers", "of", "the", "C1257987#ent", "<e2>"], "h": {"id": "C0872972", "name": "C0872972#ent", "pos": [20, 21]}, "relation": "has_structural_class", "t": {"id": "C1257987", "name": "C1257987#ent", "pos": [31, 32]}}
{"token": ["Eight-week-old", "rats", "were", "treated", "for", "4", "wk", "with", "either", "troglitazone", "or", "C0872972#ent", "<e1>", ",", "both", "of", "which", "are", "C1257987#ent", "<e2>", ",", "or", "with", "metformin", "."], "h": {"id": "C0872972", "name": "C0872972#ent", "pos": [11, 12]}, "relation": "has_structural_class", "t": {"id": "C1257987", "name": "C1257987#ent", "pos": [18, 19]}}
{"token": ["In", "other", "trials", ",", "patients", "with", "C0011881#ent", "<e1>", "hypertension", "improved", "or", "did", "not", "deteriorate", "during", "C0065374#ent", "<e2>", "treatment", "."], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [15, 16]}}
{"token": ["sTNF-rII", "and", "IL-8", "were", "positively", "associated", "with", "C0036323#ent", "<e1>", "intensity", "as", "measured", "by", "circulating", "anodic", "antigen", "(", "C1842937#ent", "<e2>", ")", ",", "regardless", "of", "HIV", "status"], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1842937", "name": "C1842937#ent", "pos": [17, 18]}}
{"token": ["H.", "cinaedi", "bacteremia", "should", "be", "suspected", "in", "HIV-infected", "individuals", "who", "present", "with", "an", "indolent", "C0015967#ent", "<e1>", "illness", ",", "particularly", "in", "the", "presence", "of", "multifocal", "cellulitis", "C0029408#ent", "<e2>", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [25, 26]}}
{"token": ["In", "a", "separate", "experiment", "belowground", "respiration", "was", "measured", "on", "N", "and", "C3887659#ent", "<e1>", "fertilized", "plant-soil", "systems", "with", "C0885100#ent", "<e2>", "treatments", "comparable", "to", "the", "first", "experiment", "."], "h": {"id": "C3887659", "name": "C3887659#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0885100", "name": "C0885100#ent", "pos": [17, 18]}}
{"token": ["Several", "indole", "analogues", "of", "melatonin", "(", "C1881490#ent", "<e1>", ")", "were", "obtained", "by", "moving", "the", "C1881490#ent", "<e1>", "side", "chain", "C(3", ")", "to", "C(2)", "the", "C0021236#ent", "<e1>"], "h": {"id": "C1881490", "name": "C1881490#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0021236", "name": "C0021236#ent", "pos": [23, 24]}}
{"token": ["We", "also", "compared", "the", "photosensitized", "photobleaching", "rate", "C1881490#ent", "<e1>", "with", "that", "of", "other", "C0021236#ent", "<e2>", ",", "which", "revealed", "that", "C1881490#ent", "<e1>", "is", "the", "most", "sensitive", "to", "1O2", "bleaching", "."], "h": {"id": "C1881490", "name": "C1881490#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021236", "name": "C0021236#ent", "pos": [13, 14]}}
{"token": ["Hereditary", "gingival", "fibromatosis", "C1420314#ent", "<e1>", ")", "is", "a", "C0037277#ent", "<e2>", "as", "a", "progressive", "enlargement", "of", "the", "gingiva", "."], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [8, 9]}}
{"token": ["This", "article", "focuses", "on", "those", "cardiac", "diseases", "are", "most", "common", "in", "the", "older", "horse", "including", "C4025230#ent", "<e1>", "aortocardiac", "fistula", ",", "and", "C0018802#ent", "<e2>"], "h": {"id": "C4025230", "name": "C4025230#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["We", "have", "replaced", "the", "C-terminal", "portion", "the", "third", "intracellular", "loop", "of", "the", "C1367657#ent", "<e1>", "residues", "266", "-", "272", ")", "with", "the", "C1334043#ent", "<e2>", "the", "alpha", "1B-adrenergic", "receptor"], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [21, 22]}}
{"token": ["We", "previously", "reported", "that", "Asn312", "of", "the", "C1367657#ent", "<e1>", "Asn385", "in", "the", "C1334043#ent", "<e2>", "the", "5-hydroxytryptamine1A", "receptor", "important", "for", "binding", "to", "a", "class", "of", "beta-adrenergic", "receptor", "antagonists", "propranolol", "and", "alprenolol", "."], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["The", "desensitization", "was", "therefore", "C1367657#ent", "<e1>", "specific", "and", "of", "the", "C1334043#ent", "<e2>"], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}}
{"token": ["C1414627#ent", "<e1>", "is", "the", "same", "as", "a", "previously", "described", "C1741214#ent", "<e2>", ",", "similar", "to", "FKBP52", "and", "cyclophilin", "40", "is", "an", "Hsp90-binding", "protein", "appears", "in", "functionally", "mature", "steroid", "receptor", "complexes", "along", "with", "Hsp90", "and", "p23", "."], "h": {"id": "C1414627", "name": "C1414627#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1741214", "name": "C1741214#ent", "pos": [9, 10]}}
{"token": ["Dickkopf", "1", "a", "selective", "antagonist", "of", "Wnt", "proteins", "binding", "to", "low-density", "lipoprotein-receptor-related", "did", "not", "influence", "activation", "of", "p38", "and", "C3849574#ent", "<e1>", "induced", "by", "C1423884#ent", "<e2>", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1423884", "name": "C1423884#ent", "pos": [23, 24]}}
{"token": ["C1423884#ent", "<e1>", "activated", "RAS", "and", "WNT3a-induced", "C3849574#ent", "<e2>", "activation", "was", "blocked", "by", "dominant-negative", "RAS", ",", "indicating", "that", "C1423884#ent", "<e1>", "might", "act", "upstream", "of", "RAS", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423884", "name": "C1423884#ent", "pos": [0, 1]}}
{"token": ["We", "show", "that", "INCENP", "has", "an", "important", "role", "in", "stabilizing", "the", "complex", ",", "and", "that", "C4282430#ent", "<e1>", "acts", "to", "promote", "binding", "of", "C1332416#ent", "<e2>", "to", "INCENP", "."], "h": {"id": "C4282430", "name": "C4282430#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [22, 23]}}
{"token": ["C1417912#ent", "<e1>", "belongs", "to", "a", "protein", "family", "C1825621#ent", "<e2>", "by", "their", "ability", "to", "catalyze", "the", "synthesis", "of", "2'-5'-linked", "oligomers", "of", "adenosine", "from", "ATP", "(", "2", "-", "5A", ")", "."], "h": {"id": "C1417912", "name": "C1417912#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1825621", "name": "C1825621#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "the", "concentrations", "of", "total", "CoA", "total", "C3812173#ent", "<e1>", "carnitine", "were", "measured", "in", "C0023899#ent", "<e2>", ",", "adrenal", "glands", "skeletal", "muscle", "the", "same", "rats", "."], "h": {"id": "C3812173", "name": "C3812173#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [15, 16]}}
{"token": ["These", "C0029896#ent", "<e1>", "are", "the", "long", "QT", "syndrome", "the", "C2678478#ent", "<e2>", "the", "catecholaminergic", "polymorphic", "ventricular", "tachycardia", "and", "the", "short", "QT", "syndrome"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2678478", "name": "C2678478#ent", "pos": [9, 10]}}
{"token": ["Studies", "in", "other", ",", "more", "recently", "described", ",", "C0029896#ent", "<e1>", "such", "as", "C2678478#ent", "<e2>", "catecholaminergic", "polymorphic", "ventricular", "arrhythmias", "and", "the", "short", "QT", "syndrome", "are", "ongoing", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2678478", "name": "C2678478#ent", "pos": [12, 13]}}
{"token": ["To", "study", "the", "interaction", "between", "C0036075#ent", "<e1>", "and", "class", "1", "C0003195#ent", "<e2>"], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [10, 11]}}
{"token": ["The", "amount", "of", "label", "incorporated", "by", "pertussis", "toxin", "these", "two", "peptides", "(", "putative", "subunits", "of", "Ni", ")", "per", "mg", "of", "C1334693#ent", "<e1>", "increased", "2", "-", "3-fold", "in", "the", "C0271801#ent", "<e2>", "state", "."], "h": {"id": "C1334693", "name": "C1334693#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0271801", "name": "C0271801#ent", "pos": [28, 29]}}
{"token": ["The", "results", "of", "this", "study", "show", "that", "C1881373#ent", "<e1>", "iron", "supplementation", "increases", "GSH", ",", "GSH-Px", "and", "C1704945#ent", "<e2>", "levels", "of", "erythrocytes", "."], "h": {"id": "C1881373", "name": "C1881373#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [16, 17]}}
{"token": ["Mutations", "in", "the", "C1417248#ent", "<e1>", "encoding", "myelin", "protein", "zero", "MPZ", ")", ",", "cause", "inherited", "C0029132#ent", "<e2>", "collectively", "called", "Charcot-Marie-Tooth", "type", "1B", "CMT1B", ")", "."], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029132", "name": "C0029132#ent", "pos": [14, 15]}}
{"token": ["Kinetic", "analysis", "C0178695#ent", "<e1>", "synthesis", "and", "release", "from", "isolated", "protoplast", "membranes", "that", "phosphorylation", "by", "C2744579#ent", "<e2>", "stimulated", "C0178695#ent", "<e1>", "release", "and", "synthesis", "."], "h": {"id": "C0178695", "name": "C0178695#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [14, 15]}}
{"token": ["In", "a", "model", "of", "C0008354#ent", "<e1>", "toxin-induced", "gut", "inflammation", ",", "C0309720#ent", "<e2>", "are", "recruited", "to", "the", "intestine", "in", "WT", "but", "not", "CCR9-deficient", "animals", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0309720", "name": "C0309720#ent", "pos": [10, 11]}}
{"token": ["Whereas", "the", "interference", "of", "C1442762#ent", "<e1>", "with", "K1", "-", "5-mediated", "effect", "was", "prevented", "by", "C0050451#ent", "<e2>", ",", "this", "lysine", "analog", "not", "abolish", "the", "proliferation", "inhibition", "of", "K1", "-", "5", "."], "h": {"id": "C1442762", "name": "C1442762#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0050451", "name": "C0050451#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "C0061300#ent", "<e1>", "on", "the", "different", "molecular", "forms", "cyclic", "nucleotide", "phosphodiesterases", "C1412691#ent", "<e2>", ")", "isolated", "from", "bovine", "aorta", "also", "determined", "."], "h": {"id": "C0061300", "name": "C0061300#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412691", "name": "C1412691#ent", "pos": [13, 14]}}
{"token": ["We", "observed", "that", "most", "patients", "with", "Helicobacter", "pylori", "infection", "iron", "deficiency", "C0002871#ent", "<e1>", "present", "a", "C0348893#ent", "<e2>"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0348893", "name": "C0348893#ent", "pos": [15, 16]}}
{"token": ["Ortho-vanadate", ",", "a", "C0597217#ent", "<e1>", "also", "stimulated", "C0388638#ent", "<e2>", "activity", "."], "h": {"id": "C0597217", "name": "C0597217#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [7, 8]}}
{"token": ["Propranolol", "(", "a", "C0597217#ent", "<e1>", "and", "Zn2+", "a", "C0388638#ent", "<e2>", "inhibitor", ")", ",", "abolish", "the", "sustained", "phase", "of", "DAG", "generation", "."], "h": {"id": "C0597217", "name": "C0597217#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [8, 9]}}
{"token": ["C2713546#ent", "<e1>", "of", "GST", "C0022173#ent", "<e2>", "may", "be", "compensated", "by", "the", "presence", "of", "other", "isoforms", "and", "by", "the", "use", "of", "alternative", "metabolic", "pathways"], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [4, 5]}}
{"token": ["C1846672#ent", "<e1>", "LGMD2I", ")", "is", "caused", "by", "mutations", "in", "the", "C1414558#ent", "<e2>", "related", "protein", "gene", "FKRP", "gene", "."], "h": {"id": "C1846672", "name": "C1846672#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414558", "name": "C1414558#ent", "pos": [10, 11]}}
{"token": ["In", "patients", "with", "C0010346#ent", "<e1>", "an", "injection", "of", "C0025677#ent", "<e2>", "in", "the", "clinically", "effective", "dose", "range", "does", "not", "raise", "rectal", "or", "plasma", "adenosine", "concentrations", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [8, 9]}}
{"token": ["Recently", ",", "CED-6", ",", "an", "C1332163#ent", "<e1>", "in", "engulfment", "has", "been", "cloned", "in", "C0949990#ent", "<e2>", "in", "humans", "."], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0949990", "name": "C0949990#ent", "pos": [13, 14]}}
{"token": ["Its", "broad", "substrate", "specificity", ",", "molecular", "weight", "and", "response", "to", "C0031686#ent", "<e1>", "suggest", "that", "the", "Acanthamoeba", "protein", "phosphatase", "is", "a", "C1335404#ent", "<e2>", "Cohen", ",", "P.", "(", "1982", ")", "Nature", "(", "Lond", ".", ")"], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335404", "name": "C1335404#ent", "pos": [20, 21]}}
{"token": ["The", "C3890207#ent", "<e1>", "4", "are", "then", "closed", "in", "the", "next", "immature", "and", "mature", "B", "cell", "until", "the", "IL-2", "opens", "the", "C3890207#ent", "<e1>", "4", "again", "as", "well", "as", "C2240327#ent", "<e1>", "to", "express", "J", "chain", "gene", "the", "primary", "immune", "responses"], "h": {"id": "C3890207", "name": "C3890207#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2240327", "name": "C2240327#ent", "pos": [27, 28]}}
{"token": ["In", "a", "double", "blind", "study", "prazosin", ",", "a", "specific", "C0304513#ent", "<e1>", "or", "placebo", "were", "given", "to", "15", "females", "with", "primary", "C0034734#ent", "<e2>", "phenomenon", "."], "h": {"id": "C0304513", "name": "C0304513#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034734", "name": "C0034734#ent", "pos": [20, 21]}}
{"token": ["The", "concentration", "of", "C1337111#ent", "<e1>", "in", "the", "median", "eminence", "reduced", "in", "animals", "exposed", "to", "C1419195#ent", "<e2>", "at", "this", "time", "."], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419195", "name": "C1419195#ent", "pos": [14, 15]}}
{"token": ["Direct", "assessment", "of", "cortical", "blood", "flow", "radionuclide", "renography", "provide", "a", "sensitive", "and", "reliable", "index", "to", "the", "diagnosis", "of", "C1412501#ent", "<e1>", ",", "with", "particular", "regard", "to", "the", "differential", "diagnosis", "C1412501#ent", "<e1>", "and", "C0268494#ent", "<e1>", "."], "h": {"id": "C1412501", "name": "C1412501#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0268494", "name": "C0268494#ent", "pos": [31, 32]}}
{"token": ["BDNF", ",", "C1706578#ent", "<e1>", ",", "and", "NT-4", "caused", "rapid", "tyrosine", "phosphorylation", "C1366882#ent", "<e2>", "and", "SNT", "."], "h": {"id": "C1706578", "name": "C1706578#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [11, 12]}}
{"token": ["inhibited", "day", "16", "uninjected", "paw", "edema", "restored", "significantly", "the", "depressed", "proliferative", "responses", "to", "C0026249#ent", "<e1>", "by", "spleen", "cells", "taken", "from", "the", "same", "C0003864#ent", "<e2>", "rats", "at", "day", "16", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [22, 23]}}
{"token": ["The", "inhibition", "of", "the", "activation", "of", "splenic", "lymphocytes", "response", "to", "C0026249#ent", "<e1>", "the", "erythema", "and", "edema", "associated", "with", "C0003864#ent", "<e2>", "were", "assayed", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [18, 19]}}
{"token": ["Methyl", "substitution", "at", "the", "2-position", "of", "the", "C0020924#ent", "<e1>", "improved", "drug", "metabolism", ",", "in", "human", "liver", "microsomes", ",", "of", "C0138837#ent", "<e2>", "FTI", ")", "candidates", "for", "drug", "development"], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [19, 20]}}
{"token": ["Abundant", "proteins", "expressed", "in", "different", "forms", "were", ":", "C0002245#ent", "<e1>", ",", "immunoglobulin", "A", "prolactin-inducible", "protein", "zinc-alpha(2)-glycoprotein", "and", "cystatins", "(", "S", ",", "C1825840#ent", "<e2>", ",", "D", "and", "SN", ")", "."], "h": {"id": "C0002245", "name": "C0002245#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [21, 22]}}
{"token": ["This", "study", "shows", "that", "the", "use", "of", "MgCl2", "and/or", "C0071785#ent", "<e1>", "in", "vesicle", "preparation", "C2712370#ent", "<e2>", "phospholipid", "and", "protein", "composition", "the", "membrane", "compared", "to", "CaCl2", "precipitation", "."], "h": {"id": "C0071785", "name": "C0071785#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [14, 15]}}
{"token": ["Although", "the", "detailed", "antioxidant", "mechanism", "remains", "to", "be", "elucidated", ",", "these", "results", "suggest", "that", "C2351517#ent", "<e1>", "vitamin", "A", "play", "a", "role", "in", "maintaining", "the", "C0003402#ent", "<e2>", "LDL", "during", "oxidative", "stress", "in", "vivo"], "h": {"id": "C2351517", "name": "C2351517#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [24, 25]}}
{"token": ["The", "effects", "have", "been", "compared", "of", "ranitidine", "and", "C0015620#ent", "<e1>", "on", "PGE2", "content", "in", "C0013295#ent", "<e2>", "patients", "."], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [14, 15]}}
{"token": ["Anti-TF", "antibodies", "also", "prove", "useful", "in", "C0007222#ent", "<e1>", "cancer", ",", "given", "the", "role", "of", "TF", "in", "these", "C0012634#ent", "<e2>", "."], "h": {"id": "C0007222", "name": "C0007222#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [17, 18]}}
{"token": ["However", ",", "serum", "removal", "or", "blockade", "of", "PI3K", "signaling", "C0251991#ent", "<e1>", "transiently", "stimulated", "basal", "C1414314#ent", "<e2>", "expression", "and", "increased", "CB1-mediated", "induction", "of", "C1414314#ent", "<e2>", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414314", "name": "C1414314#ent", "pos": [14, 15]}}
{"token": ["In", "this", "report", "we", "show", "that", "activation", "of", "C0033036#ent", "<e1>", "with", "an", "C0243192#ent", "<e2>", "anti-CD40", "mAb", "alters", "the", "behavior", "of", "CD4", "T", "cells", "in", "vivo"], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}}
{"token": ["There", "are", "several", "distinct", "C0026848#ent", "<e1>", "subtypes", "in", "the", "masticatory", "system", "including", "C0016053#ent", "<e2>", "myositis", ",", "muscle", "spasm", "and", "muscle", "contracture"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0016053", "name": "C0016053#ent", "pos": [12, 13]}}
{"token": ["C0009447#ent", "<e1>", "should", "be", "considered", "in", "any", "patient", "with", "gastrointestinal", "manifestations", "C0011991#ent", "<e2>", "association", "with", "recurrent", "bacterial", "infections", "other", "organs", "."], "h": {"id": "C0009447", "name": "C0009447#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [11, 12]}}
{"token": ["This", "study", "briefly", "reviews", "previously", "published", "cases", "reports", "a", "patient", "suffering", "from", "C0009447#ent", "<e1>", "with", "a", "history", "of", "C0011991#ent", "<e2>", "recurrent", "sinopulmonary", "infections"], "h": {"id": "C0009447", "name": "C0009447#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [18, 19]}}
{"token": ["The", "C0536221#ent", "<e1>", "the", "Apc", "protein", "the", "regulation", "of", "beta-catenin-mediated", "gene", "transcription", "and", "C1414120#ent", "<e2>", "been", "well", "described", "."], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [13, 14]}}
{"token": ["S100B", ",", "a", "small", "acidic", "calcium-binding", "protein", "is", "a", "member", "of", "the", "S100", "protein", "family", "is", "a", "C0536221#ent", "<e1>", "of", "binding", "several", "target", "molecules", ",", "such", "as", "C1414120#ent", "<e2>", "protein", "kinases", "in", "a", "calcium-dependent", "manner", "."], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [27, 28]}}
{"token": ["C0079419#ent", "<e1>", "does", "not", "bind", "to", "yeast", "C1705304#ent", "<e2>", ",", "and", "it", "can", "not", "inhibit", "transcription", "in", "a", "HeLa", "extract", "yeast", "C1705304#ent", "<e2>", "substitutes", "for", "human", "C1705304#ent", "<e2>", "."], "h": {"id": "C0079419", "name": "C0079419#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [7, 8]}}
{"token": ["Concomitantly", ",", "CDK2", ",", "but", "not", "C0246957#ent", "<e1>", ",", "activity", "immunoprecipitated", "from", "cells", "treated", "with", "C0289993#ent", "<e2>", "or", "roscovitine", "was", "markedly", "inhibited", "."], "h": {"id": "C0246957", "name": "C0246957#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0289993", "name": "C0289993#ent", "pos": [15, 16]}}
{"token": ["Particular", "emphasis", "is", "given", "to", "such", "infections", "as", "viral", "hepatitis", "rotavirus", "gastroenteritis", "C0042769#ent", "<e1>", "the", "skin", ",", "genital", ",", "and", "respiratory", "tracts", "and", "C0034494#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0034494", "name": "C0034494#ent", "pos": [23, 24]}}
{"token": ["Increased", "contractility", ",", "not", "antagonized", "by", "C0242889#ent", "<e1>", "sotalol", "or", "C0035179#ent", "<e2>", "pretreatment", ",", "was", "observed", "in", "this", "assay", "with", "a", "variety", "of", "N-substituted", "trichloroacetamidine", "derivatives", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [10, 11]}}
{"token": ["C0242889#ent", "<e1>", "propranolol", "or", "depletion", "of", "nerve", "terminal", "of", "catecholamines", "with", "C0035179#ent", "<e2>", "did", "not", "affect", "food-stimulated", "release", "of", "PYY", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [11, 12]}}
{"token": ["When", "NSCLC", "cells", "are", "exposed", "sequentially", "to", "C0759338#ent", "<e1>", "and", "a", "C1268567#ent", "<e2>", "epidermal", "growth", "factor", "receptor", "human", "epidermal", "growth", "factor", "receptor", "2", "synergistic", "activity", "is", "observed", "with", "an", "increase", "in", "the", "fraction", "of", "cells", "undergoing", "apoptosis", "."], "h": {"id": "C0759338", "name": "C0759338#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [11, 12]}}
{"token": ["We", "examined", "the", "effects", "of", "C0032594#ent", "<e1>", "on", "t-PA", "mediated", "C1367553#ent", "<e2>", "activation", "using", "single-chain", "tissue", "plasminogen", "activator", "sct-PA", ")", "and", "two-chain", "tissue", "plasminogen", "activator", "tct-PA", ")", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "C0935989#ent", "<e1>", "inhibited", "only", "Bcr-Abl-dependent", "C3853644#ent", "<e2>"], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [8, 9]}}
{"token": ["Chronic", "oral", "administration", "rotenone", "at", "high", "doses", "induced", "specific", "nigrostriatal", "DA", "neurodegeneration", ",", "motor", "deficits", "the", "up-regulation", "of", "C1420276#ent", "<e1>", "in", "the", "C1332416#ent", "<e2>", "DA", "neurons", "."], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [22, 23]}}
{"token": ["In", "each", "patient", "the", "symptoms", "corresponded", "to", "an", "atrophic", "or", "\"", "punched-out", "\"", "C0019655#ent", "<e1>", "scar", "in", "the", "C0332573#ent", "<e2>", "."], "h": {"id": "C0019655", "name": "C0019655#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0332573", "name": "C0332573#ent", "pos": [18, 19]}}
{"token": ["Our", "results", "show", "that", "for", "tRNA", "in", "complex", "with", "C0030933#ent", "<e1>", ":", "GTP", ",", "the", "C0031640#ent", "<e2>", "D17", "is", "cleaved", ",", "yet", "the", "phosphodiester", "bonds", "D16", "and", "G15", "are", "not", "."], "h": {"id": "C0030933", "name": "C0030933#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [15, 16]}}
{"token": ["Among", "the", "non-insulin", "dependent", "diabetics", "no", "difference", "in", "the", "frequency", "of", "the", "C0008287#ent", "<e1>", "alcohol", "flush", "found", "between", "those", "with", "and", "without", "a", "family", "history", "C0011849#ent", "<e2>", "."], "h": {"id": "C0008287", "name": "C0008287#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [25, 26]}}
{"token": ["Non-insulin-dependent", "diabetes", "associated", "with", "facial", "flushing", "alcohol", "in", "patients", "on", "C0008287#ent", "<e1>", "(", "C0008287#ent", "<e1>", "alcohol", "flushing", "C.P.A.F.", ")", "especially", "when", "there", "is", "a", "family", "history", "C0011849#ent", "<e1>", "."], "h": {"id": "C0008287", "name": "C0008287#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [26, 27]}}
{"token": ["Skin", "biopsy", "specimens", "of", "two", "siblings", "with", "C1415882#ent", "<e1>", "two", "siblings", "with", "C0086648#ent", "<e2>", "examined", "by", "electron", "microscopy", "at", "six-month", "intervals", ",", "before", "and", "after", "plasma", "infusion", "therapy"], "h": {"id": "C1415882", "name": "C1415882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086648", "name": "C0086648#ent", "pos": [12, 13]}}
{"token": ["The", "importance", "of", "prompt", "diagnosis", "of", "C0023885#ent", "<e1>", "means", "of", "C3813556#ent", "<e2>", "and", "ultrasonography", "is", "stressed", "."], "h": {"id": "C0023885", "name": "C0023885#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [10, 11]}}
{"token": ["Literature", "data", "on", "the", "properties", "of", "chloroquine", "phosphate", "chloroquine", "sulfate", "and", "C0008269#ent", "<e1>", "to", "the", "Biopharmaceutics", "Classification", "System", "C1412777#ent", "<e2>", ")", "are", "reviewed", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412777", "name": "C1412777#ent", "pos": [18, 19]}}
{"token": ["Intraseptal", "microinjection", "C0242894#ent", "<e1>", "carbachol", ")", "produced", "almost", "a", "continuous", "C0238339#ent", "<e2>", "theta", "with", "increased", "amplitude", "and", "power", "."], "h": {"id": "C0242894", "name": "C0242894#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0238339", "name": "C0238339#ent", "pos": [10, 11]}}
{"token": ["C0289499#ent", "<e1>", "is", "a", "cell", "penetrating", "peptide", "C1413682#ent", "<e2>", ")", "derived", "from", "the", "nuclear", "localization", "sequence", "Simian", "Virus", "large", "antigen", "T", "from", "reverse", "transcriptase", "Human", "Immunodeficiency", "Virus"], "h": {"id": "C0289499", "name": "C0289499#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [7, 8]}}
{"token": ["C0289499#ent", "<e1>", "is", "a", "tryptophane-rich", "cell-penetrating", "peptide", "(", "C1413682#ent", "<e2>", ")", "that", "has", "been", "previously", "proposed", "to", "bind", "protein", "cargoes", "by", "hydrophobic", "assembly", "and", "translocate", "them", "across", "cellular", "membranes"], "h": {"id": "C0289499", "name": "C0289499#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "a", "dominant-negative", "form", "of", "C1332740#ent", "<e1>", "inhibits", "the", "pro-myogenic", "effects", "of", "soluble", "C1826625#ent", "<e2>", ",", "suggesting", "that", "C1826625#ent", "<e2>", "is", "dependent", "on", "C1332740#ent", "<e1>", "for", "its", "activity", "."], "h": {"id": "C1826625", "name": "C1826625#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332740", "name": "C1332740#ent", "pos": [6, 7]}}
{"token": ["In", "C0043119#ent", "<e1>", "though", "arteriosclerosis", "arises", "frequently", ",", "case", "reports", "C0022661#ent", "<e2>", "extremely", "rare", "."], "h": {"id": "C0043119", "name": "C0043119#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [10, 11]}}
{"token": ["High", "C1413057#ent", "<e1>", "and", "TK", "activities", "and", "the", "existence", "of", "TK", "C0022173#ent", "<e2>", "have", "been", "observed", "in", "rapidly", "proliferating", "tissues", "."], "h": {"id": "C1413057", "name": "C1413057#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "to", "assess", "the", "efficacy", "of", "this", "type", "of", "combination", "therapy", "C0011860#ent", "<e1>", "we", "conducted", "a", "double-blind", "clinical", "trial", "with", "C0040372#ent", "<e2>", "and", "insulin", "in", "15", "subjects", "with", "C0011860#ent", "<e1>"], "h": {"id": "C0040372", "name": "C0040372#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}}
{"token": ["Micropuncture", "and", "clearance", "studies", "were", "performed", "to", "assess", "reabsorptive", "function", "the", "proximal", "and", "C0022672#ent", "<e1>", "rats", "with", "experimental", "Fanconi's", "syndrome", "induced", "by", "C0028928#ent", "<e2>"], "h": {"id": "C0022672", "name": "C0022672#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [22, 23]}}
{"token": ["In", "the", "current", "study", ",", "the", "authors", "used", "a", "mouse", "model", "C0035369#ent", "<e1>", "study", "the", "contribution", "of", "C1332699#ent", "<e2>", "to", "neuropathogenesis", "in", "the", "absence", "of", "lymphocyte", "recruitment", "to", "the", "CNS", "."], "h": {"id": "C0035369", "name": "C0035369#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332699", "name": "C1332699#ent", "pos": [17, 18]}}
{"token": ["The", "serological", "determinants", "Rodgers", "(", "Rg1", ",", "Rg2", ")", "and", "Chido", "(", "Ch1", ",", "Ch2", ",", "C0769345#ent", "<e1>", ")", "are", "generally", "associated", "with", "C4A", "and", "C1412999#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [25, 26]}}
{"token": ["MRI", "C0013604#ent", "<e1>", "been", "observed", "in", "early", "and", "advanced", "C0003873#ent", "<e2>", "and", "may", "represent", "a", "cellular", "infiltrate", "osteitis", ")", "in", "subchondral", "bone"], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}}
{"token": ["Control", "experiments", "that", "the", "increase", "in", "C0017789#ent", "<e1>", "and", "glutamine", "levels", "is", "due", "to", "C1418984#ent", "<e2>", "rather", "than", "to", "the", "stress", "associated", "with", "experimental", "procedure"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418984", "name": "C1418984#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "highlight", "the", "implications", "for", "using", "murine", "models", "to", "study", "the", "bovine", "immune", "response", "C0041230#ent", "<e1>", ",", "where", "in", "some", "cases", "C1333196#ent", "<e2>", "expression", "patterns", "differ", "."], "h": {"id": "C0041230", "name": "C0041230#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [22, 23]}}
{"token": ["Eslicarbazepine", "acetate", "a", "promising", "C0003299#ent", "<e1>", "related", "to", "carbamazepine", "and", "C0069751#ent", "<e2>", ",", "which", "is", "in", "the", "final", "phase", "of", "clinical", "development"], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [4, 5]}, "relation": "therapeutic_class_of", "t": {"id": "C0069751", "name": "C0069751#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "there", "have", "been", "strategies", "to", "improve", "the", "pharmacokinetics", "of", "currently", "used", "C0003299#ent", "<e1>", "we", "have", "concentrated", "on", "controlled-release", "carbamazepine", "and", "C0069751#ent", "<e2>", ",", "both", "available", "in", "certain", "countries", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [14, 15]}, "relation": "therapeutic_class_of", "t": {"id": "C0069751", "name": "C0069751#ent", "pos": [23, 24]}}
{"token": ["Incubation", "of", "a", "ternary", "complex", "C0080054#ent", "<e1>", ",", "cyclin", "B", "and", "the", "COOH-terminal", "domain", "C0127014#ent", "<e2>", ",", "PA4", ",", "with", "ATP", "resulted", "in", "intracomplex", "phosphorylation", "PA4", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0127014", "name": "C0127014#ent", "pos": [14, 15]}}
{"token": ["Ser-696", "and", "Ser-787", ",", "both", "of", "which", "lie", "within", "SPXK", "consensus", "sequences", "C0080054#ent", "<e1>", "were", "identified", "as", "phosphorylation", "sites", "in", "the", "proline-rich", "region", "C0127014#ent", "<e2>", "in", "vivo", "in", "vitro"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0127014", "name": "C0127014#ent", "pos": [23, 24]}}
{"token": ["C0080054#ent", "<e1>", "kinase-phosphorylation", "sites", "in", "the", "microtubule", "(MT)-binding", "region", "of", "C0127014#ent", "<e2>", "were", "determined", "by", "peptide", "sequence", "phosphorylated", "MTB3", ",", "a", "fragment", "containing", "the", "carboxy-terminal", "half", "human", "C0127014#ent", "<e2>", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0127014", "name": "C0127014#ent", "pos": [10, 11]}}
{"token": ["The", "precursor", "to", "C0025677#ent", "<e1>", "alpha-methyl", "ester", "prepared", "from", "gamma-benzyl", "ester", "6", "by", "treatment", "with", "C0751122#ent", "<e2>", "in", "DMF", "containing", "(i-Pr)2NEt", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751122", "name": "C0751122#ent", "pos": [15, 16]}}
{"token": ["Cells", "were", "tested", "for", "adherence", "to", "larvae", "which", "had", "been", "sensitised", "with", "immune", "mouse", "serum", "IMS", ")", "or", "normal", "mouse", "serum", "(", "C1744687#ent", "<e1>", ")", "in", "the", "presence", "of", "CA2+", "C0001477#ent", "<e2>", "ions", "."], "h": {"id": "C1744687", "name": "C1744687#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [30, 31]}}
{"token": ["This", "network", "also", "accommodates", "effects", "of", "C0950080#ent", "<e1>", "mutual", "repression", "circuits", "of", "Gfi1", "against", "Egr-2", "and", "of", "C3273688#ent", "<e2>", "against", "PU.1", "as", "proposed", "elsewhere", ",", "but", "requires", "additional", "functions", "that", "remain", "unidentified", "."], "h": {"id": "C0950080", "name": "C0950080#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273688", "name": "C3273688#ent", "pos": [17, 18]}}
{"token": ["Intra-articular", "perfusion", "C1161352#ent", "<e1>", "potentiated", "the", "inhibition", "of", "C1537501#ent", "<e2>", "plasma", "extravasation", "systemic", "carbachol", "indicating", "that", "muscarinic", "receptors", "the", "synovium", "also", "contribute", "to", "plasma", "extravasation"], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [8, 9]}}
{"token": ["The", "muscarinic", "receptor", "antagonist", "C1161352#ent", "<e1>", "(", "0.1", "microM", ")", ",", "the", "C1537501#ent", "<e2>", "10", "microM", ")", "and", "the", "angiotensin", "converting", "enzyme", "inhibitor", "captopril", "(", "20", "microM", ")", "did", "not", "affect", "either", "phase", "of", "the", "venom", "response", "guinea-pig", "ileum"], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [12, 13]}}
{"token": ["Increased", "apoptosis", "with", "C0019693#ent", "<e1>", "and", "TGF-beta1", "was", "associated", "with", "reduced", "levels", "of", "C0376515#ent", "<e2>", "and", "increased", "expression", "of", "apoptosis-inducing", "factor", "caspase-3", ",", "and", "cleavage", "of", "BID", ",", "c-IAP-1", ",", "and", "X-linked", "inhibitor", "apoptosis", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [13, 14]}}
{"token": ["The", "antibody", "was", "shown", "to", "inhibit", "the", "activity", "of", "the", "C0031667#ent", "<e1>", "well", "as", "that", "of", "the", "C3539768#ent", "<e2>"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [10, 11]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [17, 18]}}
{"token": ["C0031667#ent", "<e1>", "PLA2L", ")", "belongs", "to", "the", "secreted", "forms", "of", "C3539768#ent", "<e2>", "but", "constitutes", "a", "new", "subgroup", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [0, 1]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "explore", "the", "role", "of", "C1423014#ent", "<e1>", "in", "hyper-responsiveness", "of", "bronchial", "smooth", "muscle", "antigen-induced", "C1706481#ent", "<e2>", "rats", "."], "h": {"id": "C1423014", "name": "C1423014#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706481", "name": "C1706481#ent", "pos": [21, 22]}}
{"token": ["The", "levels", "of", "ET-1-induced", "phosphorylation", "of", "C1423014#ent", "<e1>", "and", "MLC", "were", "increased", "much", "more", "markedly", "in", "the", "C1706481#ent", "<e2>", "group", "than", "in", "the", "sensitized", "control", "animals", "."], "h": {"id": "C1423014", "name": "C1423014#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706481", "name": "C1706481#ent", "pos": [17, 18]}}
{"token": ["Glycogen", "synthase", "purified", "from", "diabetic", "rabbits", "was", "phosphorylated", "in", "vitro", "this", "C0536221#ent", "<e1>", "only", "10", "%", "of", "the", "rate", "compared", "to", "C1538973#ent", "<e2>", "purified", "from", "control", "rabbits"], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1538973", "name": "C1538973#ent", "pos": [21, 22]}}
{"token": ["We", "conclude", "that", "C0771311#ent", "<e1>", "is", "a", "highly", "potent", "C0012544#ent", "<e2>", "and", "that", "a", "single", "intravenous", "infusion", "is", "capable", "of", "inhibiting", "tumour-mediated", "bone", "resorption", "for", "several", "days", "."], "h": {"id": "C0771311", "name": "C0771311#ent", "pos": [3, 4]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [9, 10]}}
{"token": ["At", "present", ",", "bisphosphonates", "are", "the", "most", "commonly", "prescribed", "pharmacological", "treatments", "osteoporosis", ",", "and", "C0771311#ent", "<e1>", "the", "most", "frequently", "prescribed", "C0012544#ent", "<e2>", "."], "h": {"id": "C0771311", "name": "C0771311#ent", "pos": [14, 15]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [20, 21]}}
{"token": ["In", "addition", "to", "interaction", "with", "the", "retinoblastoma", "family", "protein", "p107", "the", "NTD", "has", "been", "shown", "to", "interact", "with", "alpha-tubulin", "and", "the", "novel", "adaptor", "proteins", ",", "MM-1", ",", "C3263719#ent", "<e1>", ",", "TRRAP", ",", "and", "C1417525#ent", "<e2>", "."], "h": {"id": "C3263719", "name": "C3263719#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1417525", "name": "C1417525#ent", "pos": [33, 34]}}
{"token": ["IDO", "activity", "is", "characterized", "best", "by", "the", "kynurenine", "to", "C1564483#ent", "<e1>", "correlates", "with", "concentrations", "of", "C1337091#ent", "<e2>", "such", "as", "neopterin", "."], "h": {"id": "C1564483", "name": "C1564483#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [15, 16]}}
{"token": ["C2757070#ent", "<e1>", "alone", "increased", "C1522455#ent", "<e2>", "and", "bFGF", "mRNA", "levels", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522455", "name": "C1522455#ent", "pos": [4, 5]}}
{"token": ["Estrogen", "and", "C2757070#ent", "<e1>", "together", "increased", "C1522455#ent", "<e2>", "mRNA", "level", "in", "mammary", "gland", "but", "the", "increase", "was", "no", "greater", "than", "that", "caused", "by", "either", "hormone", "alone", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522455", "name": "C1522455#ent", "pos": [6, 7]}}
{"token": ["In", "the", "present", "studies", ",", "we", "investigated", "the", "activity", "of", "tyrosylprotein", "sulfotransferase", "TPST", ")", "in", "the", "Golgi", "apparatus", "PC12", "cells", "the", "regulation", "of", "this", "C0027203#ent", "<e1>", "by", "2-chloroadenosine", ",", "an", "C2917322#ent", "<e2>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C2917322", "name": "C2917322#ent", "pos": [30, 31]}}
{"token": ["Strikingly", ",", "our", "analysis", "by", "in", "situ", "hybridization", "that", "the", "transcription", "factor", "C1418202#ent", "<e1>", ",", "is", "up", "regulated", "in", "the", "olfactory", "sensory", "epithelia", "response", "to", "C1572795#ent", "<e2>", "."], "h": {"id": "C1418202", "name": "C1418202#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1572795", "name": "C1572795#ent", "pos": [25, 26]}}
{"token": ["In", "a", "previous", "study", "we", "overexpressed", "the", "thapsigargin", "(tg)-insensitive", "Pmr1", "C0001477#ent", "<e1>", "pump", "of", "the", "Golgi", "apparatus", "C0949990#ent", "<e2>", "COS-1", "cells", "studied", "the", "properties", "of", "the", "C0001477#ent", "<e1>", "into", "which", "it", "was", "integrated", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [10, 11]}}
{"token": ["Until", "recently", ",", "the", "C0206744#ent", "<e1>", "of", "these", "inflammatory", "influxes", "thought", "to", "consist", "of", "C1423842#ent", "<e2>", "or", "Th2", "type", "cells", "however", "a", "third", "group", "of", "cells", "termed", "Th17", "have", "been", "identified", "."], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "expression", "of", "CD26", "on", "C0206744#ent", "<e1>", "been", "shown", "to", "correlate", "with", "the", "production", "of", "C1423842#ent", "<e2>", "cytokines", "."], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [16, 17]}}
{"token": ["Neuronal", "nicotinic", "receptors", "nAChR", ")", "are", "pentameric", "assemblies", "subunits", "of", "a", "C1335597#ent", "<e1>", "specified", "combinations", "of", "alpha", "and", "C0599220#ent", "<e2>", "functional", "receptors"], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [18, 19]}}
{"token": ["Several", "genetic", "errors", "alpha-synuclein", "(", "C2983377#ent", "<e1>", ")", "and", "ubiquitin", "carboxyl-terminal-hydrolase", "L1(Park5", ")", "genes", "cause", "autosomal", "dominant", "C0030567#ent", "<e2>"], "h": {"id": "C2983377", "name": "C2983377#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [17, 18]}}
{"token": ["The", "successful", "determination", "of", "C0013227#ent", "<e1>", "soft", "formulations", "such", "as", "an", "antiseptic", "cream", "chlorhexidine", ")", "and", "a", "C0358855#ent", "<e2>", "is", "also", "presented", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0358855", "name": "C0358855#ent", "pos": [17, 18]}}
{"token": ["We", "performed", "genetic", "analysis", "C0038296#ent", "<e1>", ",", "the", "gene", "encoding", "C1413856#ent", "<e2>", "in", "three", "patients", "with", "classic", "11", "beta-hydroxylase", "deficiency", "."], "h": {"id": "C0038296", "name": "C0038296#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413856", "name": "C1413856#ent", "pos": [10, 11]}}
{"token": ["C0038296#ent", "<e1>", "encoded", "by", "two", "homologous", "genes", "C1413856#ent", "<e2>", "and", "CYP11B2", ",", "located", "on", "chromosome", "8q21", "22", "."], "h": {"id": "C0038296", "name": "C0038296#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413856", "name": "C1413856#ent", "pos": [7, 8]}}
{"token": ["We", "describe", "a", "newborn", "with", "congenital", "toxoplasmosis", "presented", "with", "fever", "due", "to", "hypothalamo-pituitary", "dysregulation", "and", "combined", "hypothalamo-pituitary", "deficiencies", "of", "C0011848#ent", "<e1>", "hypothyroidism", "and", "C0342388#ent", "<e2>"], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0342388", "name": "C0342388#ent", "pos": [23, 24]}}
{"token": ["The", "iron", "chelator", "deferoxamine", "30", "mg/kg", "per", "day", "ip", ")", "significantly", "reduced", "iron", "accumulation", "and", "tubular", "damage", "C1706165#ent", "<e1>", "at", "4", "wk", ",", "compared", "with", "C1511755#ent", "<e2>", "chelated", "to", "iron", "and", "untreated", "C1706165#ent", "<e1>", "."], "h": {"id": "C1511755", "name": "C1511755#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1706165", "name": "C1706165#ent", "pos": [17, 18]}}
{"token": ["A", "four-month-old", "female", "infant", "initially", "became", "C0231218#ent", "<e1>", "with", "intermittent", "fever", ",", "followed", "by", "C0376175#ent", "<e2>", "left", "otorrhea", "days", "later", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0376175", "name": "C0376175#ent", "pos": [14, 15]}}
{"token": ["This", "article", "discusses", "causes", ",", "symptoms", ",", "diagnosis", ",", "and", "treatment", "of", "the", "most", "common", "fungal", "infections", "the", "perionychium", ",", "including", "C0040247#ent", "<e1>", "onychomycosis", ",", "and", "C0581341#ent", "<e2>"], "h": {"id": "C0040247", "name": "C0040247#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0581341", "name": "C0581341#ent", "pos": [26, 27]}}
{"token": ["DNA", "analysis", "the", "C1367578#ent", "<e1>", "a", "patient", "with", "complete", "C0039585#ent", "<e2>", "a", "substitutional", "mutation", "tyrosine", "converted", "to", "cysteine", "at", "position", "571", ")", "in", "the", "DNA", "binding", "domain"], "h": {"id": "C1367578", "name": "C1367578#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0039585", "name": "C0039585#ent", "pos": [9, 10]}}
{"token": ["Using", "C2748572#ent", "<e1>", ",", "both", "Oct4", "and", "C1420322#ent", "<e2>", "were", "genetically", "fused", "with", "a", "TAT", "protein", "transduction", "domain", "that", "promotes", "cellular", "penetration"], "h": {"id": "C2748572", "name": "C2748572#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420322", "name": "C1420322#ent", "pos": [7, 8]}}
{"token": ["Although", "C0090306#ent", "<e1>", "has", "not", "been", "proven", "to", "cause", "uveitis", "or", "C0271051#ent", "<e2>", "case", "reports", "an", "association", "exist", "."], "h": {"id": "C0090306", "name": "C0090306#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0271051", "name": "C0271051#ent", "pos": [11, 12]}}
{"token": ["Incubation", "of", "SKBR-3", "cells", "with", "the", "C1268567#ent", "<e1>", "herbimycin", "A", "induces", "a", "concentration-dependent", "reduction", "of", "C0020374#ent", "<e2>", "with", "an", "IC50", "of", "80nM.", "The", "inhibition", "of", "C0020374#ent", "<e2>", "by", "herbimycin", "A", "is", "also", "time-dependent", "."], "h": {"id": "C1268567", "name": "C1268567#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [15, 16]}}
{"token": ["Serum", "C0051696#ent", "<e1>", "levels", "were", "determined", "in", "18", "patients", "with", "C0002963#ent", "<e2>"], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [10, 11]}}
{"token": ["Other", "clinical", "studies", "shown", "C0051696#ent", "<e1>", "to", "be", "effective", "when", "used", "once-daily", "in", "chronic", "stable", "angina", "C0002963#ent", "<e2>"], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [16, 17]}}
{"token": ["There", "is", "preliminary", "evidence", "that", "C0051696#ent", "<e1>", "is", "efficacious", "and", "well", "tolerated", "in", "C0002963#ent", "<e2>"], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [13, 14]}}
{"token": ["C0025872#ent", "<e1>", "has", "notable", "effectiveness", "in", "treating", "anaerobic", "C0000833#ent", "<e2>"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [8, 9]}}
{"token": ["Third-generation", "cephalosporins", "C0025872#ent", "<e1>", "are", "the", "most", "commonly", "used", "antimicrobial", "agents", "the", "treatment", "of", "C0000833#ent", "<e2>"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [14, 15]}}
{"token": ["The", "net", "result", "in", "the", "lung", "is", "often", "the", "clinical", "picture", "acute", "lung", "injury", "C0476273#ent", "<e1>", "refractory", "hypoxemia", ",", "diffuse", "alveolar", "infiltrates", ",", "and", "C0264490#ent", "<e2>"], "h": {"id": "C0476273", "name": "C0476273#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [24, 25]}}
{"token": ["The", "occurrence", "of", "C0206607#ent", "<e1>", "that", "of", "other", "C0042769#ent", "<e2>", "detected", "in", "1998", "and", "1999", "due", "to", "outbreaks", "of", "enterovirus", "71", "and", "coxsackievirus", "A10"], "h": {"id": "C0206607", "name": "C0206607#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [8, 9]}}
{"token": ["C0005301#ent", "<e1>", "was", "evaluated", "for", "the", "prevention", "of", "C0221423#ent", "<e2>", "in", "a", "laboratory", "and", "sea", "study"], "h": {"id": "C0005301", "name": "C0005301#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [8, 9]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "effectiveness", "of", "a", "biological", "supplement", "FloRelax", ",", "C0653807#ent", "<e1>", "in", "this", "C1848862#ent", "<e2>", "."], "h": {"id": "C0653807", "name": "C0653807#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [20, 21]}}
{"token": ["Collectively", ",", "these", "data", "demonstrate", "that", "the", "recE+", "gene", "has", "been", "cloned", "and", "that", "this", "C0017337#ent", "<e1>", "elaborates", "the", "45-kilodalton", "protein", "that", "is", "involved", "in", "C0013404#ent", "<e2>", "induction", "and", "homologous", "recombination"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [25, 26]}}
{"token": ["Recently", ",", "increased", "renal", "excretion", "C0007258#ent", "<e1>", "was", "observed", "in", "dogs", "diagnosed", "with", "C0019880#ent", "<e2>", "and", "carnitine", "deficiency"], "h": {"id": "C0007258", "name": "C0007258#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "the", "mutant", "C3541394#ent", "<e1>", "exhibited", "near", "wild-type", "activity", "with", "two", "protein", "substrates", ",", "C3853636#ent", "<e2>", "ribonuclease", "T1", "whose", "folding", "is", "accelerated", "by", "prolyl", "isomerases"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3853636", "name": "C3853636#ent", "pos": [16, 17]}}
{"token": ["Pemetrexed", "is", "a", "novel", "antifolate", "that", "inhibits", "three", "C3541394#ent", "<e1>", "in", "the", "de", "novo", "purine", "and", "pyrimidine", "pathways", "thymidylate", "synthase", "C3853636#ent", "<e2>", "and", "glycinamide", "ribonucleotide", "formyltransferase"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3853636", "name": "C3853636#ent", "pos": [20, 21]}}
{"token": ["C0005330#ent", "<e1>", "offers", "the", "possibility", "of", "correcting", "disturbances", "of", "lipid", "metabolism", "C1704461#ent", "<e2>", "patients", ",", "possibly", "involved", "in", "the", "pathogenesis", "of", "atherosclerosis", "of", "these", "patients", "."], "h": {"id": "C0005330", "name": "C0005330#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704461", "name": "C1704461#ent", "pos": [11, 12]}}
{"token": ["C0002892#ent", "<e1>", "a", "common", "cause", "of", "C0002888#ent", "<e2>", "the", "world", "and", "especially", "in", "persons", "of", "European", "or", "African", "descent"], "h": {"id": "C0002892", "name": "C0002892#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0002888", "name": "C0002888#ent", "pos": [6, 7]}}
{"token": ["C0002892#ent", "<e1>", "an", "organ-specific", "autoimmune", "disease", "by", "cobalamin", "deficiency", "C0002888#ent", "<e2>", "neuropathy", ",", "and", "autoimmune", "gastritis", "anti-intrinsic", "factor", "autoantibodies"], "h": {"id": "C0002892", "name": "C0002892#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0002888", "name": "C0002888#ent", "pos": [9, 10]}}
{"token": ["These", "data", "indicate", "that", "C0071001#ent", "<e1>", "is", "very", "effective", "in", "augmenting", "basal", "and", "stimulated", "C3539616#ent", "<e2>", "secretion", "in", "old", "dog"], "h": {"id": "C0071001", "name": "C0071001#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "the", "autolytic", "activity", "the", "D-alanine", "mutant", "was", "reduced", "compared", "to", "the", "C2987364#ent", "<e1>", ",", "and", "the", "mutant", "was", "more", "susceptible", "to", "the", "C0024370#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024370", "name": "C0024370#ent", "pos": [24, 25]}}
{"token": ["TUNEL", "staining", "C0291573#ent", "<e1>", "increased", "in", "the", "ganglion", "cell", "layer", "C1825379#ent", "<e2>", ")", "in", "the", "treated", "eyes", "and", "seldom", "found", "in", "the", "control", "eyes"], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1825379", "name": "C1825379#ent", "pos": [10, 11]}}
{"token": ["The", "C0006684#ent", "<e1>", "Co2", "+", "prevented", "the", "dendritic", "regression", "cell", "death", "by", "both", "C0017789#ent", "<e2>", "and", "K+", "indicating", "that", "calcium", "influx", "required", "for", "the", "neuroarchitectural", "responses", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [13, 14]}}
{"token": ["He", "also", "described", "a", "new", "form", "of", "C0008312#ent", "<e1>", "characterized", "by", "the", "presence", "of", "C0221253#ent", "<e2>", "and", "hyperlipidemia", "with", "normal", "translucent", "plasma", "."], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221253", "name": "C0221253#ent", "pos": [14, 15]}}
{"token": ["These", "microsomes", "catalyzed", "the", "C0038302#ent", "<e1>", "of", "NPIP", "more", "efficiently", "than", "that", "of", "C1332823#ent", "<e2>", "."], "h": {"id": "C0038302", "name": "C0038302#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "modifiers", "of", "liver", "mixed", "function", "activity", "on", "the", "in", "vitro", "C0038302#ent", "<e1>", "and", "mutagenicity", "of", "N-nitrosopyrrolidine", "(", "C1332823#ent", "<e2>", ")", "has", "been", "examined", "in", "rats", "and", "hamsters", "."], "h": {"id": "C0038302", "name": "C0038302#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [20, 21]}}
{"token": ["Patients", "present", "within", "a", "broad", "spectrum", "of", "phenotypes", "from", "severe", "(", "C0086795#ent", "<e1>", "to", "clinically", "less", "severe", "(", "C0086431#ent", "<e2>", "."], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C0086431", "name": "C0086431#ent", "pos": [18, 19]}}
{"token": ["To", "date", ",", "a", "number", "of", "mutations", "of", "the", "IDUA", "gene", "known", "in", "C0086795#ent", "<e1>", "but", "only", "a", "few", "in", "Hurler", "Scheie", "C0086431#ent", "<e2>"], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0086431", "name": "C0086431#ent", "pos": [22, 23]}}
{"token": ["The", "PMA", "induction", "of", "c-fos", "mRNA", "correlated", "well", "with", "TNF", "gene", "induction", "expression", "of", "C0017337#ent", "<e1>", "encoding", "other", "proteins", "in", "the", "AP-1", "complex", "C0812313#ent", "<e2>", "and", "junD", ")", "were", "also", "induced", "by", "PMA", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812313", "name": "C0812313#ent", "pos": [23, 24]}}
{"token": ["We", "report", "here", "that", "an", "early", "effect", "TGF", "beta", "is", "an", "enhancement", "of", "the", "expression", "of", "two", "C0017337#ent", "<e1>", "encoding", "serum-", "and", "phorbol", "ester", "tumor", "promoter-regulated", "transcription", "factors", "the", "C0812313#ent", "<e2>", "the", "c-jun", "proto-oncogene", "respectively", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0812313", "name": "C0812313#ent", "pos": [29, 30]}}
{"token": ["The", "lethal", "effect", "of", "the", "C0014442#ent", "<e1>", "is", "explicable", "by", "the", "finding", "that", "injection", "of", "C0008391#ent", "<e2>", "treated", "low-density", "lipoprotein", "normal", "rabbits", ",", "in", "contrast", "to", "untreated", "low-density", "lipoprotein", "does", "not", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008391", "name": "C0008391#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "effects", "of", "trimetazidine", "and", "C0136123#ent", "<e1>", "on", "myocardial", "function", "metabolism", "in", "patients", "with", "C0018801#ent", "<e2>", "myocardial", "infarction"], "h": {"id": "C0136123", "name": "C0136123#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [15, 16]}}
{"token": ["Her", "C0032617#ent", "<e1>", "was", "caused", "by", "C0687720#ent", "<e2>"], "h": {"id": "C0032617", "name": "C0032617#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0687720", "name": "C0687720#ent", "pos": [6, 7]}}
{"token": ["The", "current", "study", "was", "undertaken", "to", "investigate", "the", "effects", "of", "pretreatment", "with", "isoflurane", "and", "C0074414#ent", "<e1>", "on", "the", "development", "of", "C0340098#ent", "<e2>", "an", "animal", "model"], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0340098", "name": "C0340098#ent", "pos": [20, 21]}}
{"token": ["Expression", "of", "C1334087#ent", "<e1>", "C1334087#ent", "<e1>", "not", "enhanced", "by", "eosinophil", "activation", "with", "platelet-activating", "factor", "C0235480#ent", "<e1>", ")", "."], "h": {"id": "C1334087", "name": "C1334087#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [14, 15]}}
{"token": ["C0005372#ent", "<e1>", "blocked", "the", "fast", "IPSPs", "which", "reversed", "near", "the", "C3147238#ent", "<e2>", "equilibrium", "potential", "(", "-71", "+", "/-", "5", "mV", ")", ",", "indicating", "their", "mediation", "by", "gamma-aminobutyric", "acid", "(GABA)A", "receptors"], "h": {"id": "C0005372", "name": "C0005372#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3147238", "name": "C3147238#ent", "pos": [10, 11]}}
{"token": ["To", "clarify", "loliginid", "phylogeny", ",", "regions", "of", "two", "C1563761#ent", "<e1>", "the", "16S", "rRNA", "the", "C4284184#ent", "<e2>", "were", "sequenced", "for", "members", "of", "19", "loliginid", "species", "and", "several", "outgroups", "."], "h": {"id": "C1563761", "name": "C1563761#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284184", "name": "C4284184#ent", "pos": [14, 15]}}
{"token": ["We", "have", "analyzed", "the", "genetic", "composition", "the", "S.", "intermedius", "forms", "using", "the", "nucleotide", "sequences", "the", "C1563761#ent", "<e1>", "encoding", "the", "C4284184#ent", "<e2>", "the", "nuclear", "gene", "encoding", "bindin", "to", "evaluate", "the", "possibility", "of", "cryptic", "species", "S.", "intermedius", "."], "h": {"id": "C1563761", "name": "C1563761#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4284184", "name": "C4284184#ent", "pos": [19, 20]}}
{"token": ["Cardiac", "troponin", "Tn", ")", "I", "(", "C3538828#ent", "<e1>", ")", ",", "compared", "with", "skeletal", "TnI", "contains", "C0815040#ent", "<e2>", "32", "to", "33", ")", "at", "its", "amino", "terminus", ",", "including", "two", "adjacent", "serine", "residues", "."], "h": {"id": "C3538828", "name": "C3538828#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [15, 16]}}
{"token": ["The", "typical", "clinical", "picture", "the", "exclusion", "of", "other", "causes", "of", "C0022658#ent", "<e1>", "the", "diagnosis", "of", "C0268769#ent", "<e2>", "be", "made", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0268769", "name": "C0268769#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicated", "that", "C1413218#ent", "<e1>", "is", "involved", "in", "the", "biosynthesis", "of", "C4082270#ent", "<e2>", "."], "h": {"id": "C1413218", "name": "C1413218#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4082270", "name": "C4082270#ent", "pos": [12, 13]}}
{"token": ["His", "serum", "levels", "of", "C3714642#ent", "<e1>", "and", "osmotic", "value", "low", "and", "serum", "creatine", "phosphokinase", "C1418571#ent", "<e2>", ")", "was", "elevated", "to", "2,624", "mg/dl", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418571", "name": "C1418571#ent", "pos": [14, 15]}}
{"token": ["Increasing", "the", "C1334896#ent", "<e1>", "inhibited", "FTF-dependent", "trans-activation", "of", "rabbit", "C1420087#ent", "<e2>", "."], "h": {"id": "C1334896", "name": "C1334896#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420087", "name": "C1420087#ent", "pos": [9, 10]}}
{"token": ["Feeding", "SC-435", "to", "the", "rabbits", "blocked", "bile", "acid", "absorption", "decreased", "C1334896#ent", "<e1>", "mRNA", ",", "and", "increased", "C1420087#ent", "<e2>", "expression", "."], "h": {"id": "C1334896", "name": "C1334896#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420087", "name": "C1420087#ent", "pos": [16, 17]}}
{"token": ["However", ",", "ingestion", "of", "increasing", "concentrations", "of", "menhaden", "oil", "increased", "hepatic", "microsomal", "cytochrome", "P-450", "content", "and", "the", "apparent", "Vmax", "for", "ethylmorphine", "N-demethylase", "C0010763#ent", "<e1>", "(", "DMN", ")", "N-demethylase", ",", "and", "C0005080#ent", "<e2>", "[", "B(a)P", "]", "hydroxylase", "."], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0005080", "name": "C0005080#ent", "pos": [30, 31]}}
{"token": ["Patients", "with", "CML", "in", "blast", "crisis", "or", "with", "Philadelphia", "positive", "acute", "lymphoblastic", "leukaemia", "C0812385#ent", "<e1>", ")", ",", "can", "have", "a", "smaller", "C1835417#ent", "<e2>", "fusion", "transcript", "possessing", "only", "the", "first", "exon", "of", "BCR", "fused", "to", "ABL", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [13, 14]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1835417", "name": "C1835417#ent", "pos": [21, 22]}}
{"token": ["Thiazide", "diuretics", "may", "cause", "electrolyte", "disturbances", ",", "dehydration", "and", "hyperuricemia", ",", "C0001645#ent", "<e1>", "may", "cause", "bronchospasm", ",", "bradycardia", ",", "cold", "extremities", "C0037317#ent", "<e2>", "calcium", "antagonists", "cause", "flushing", ",", "ankle", "oedema", "gingival", "hyperplasia"], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037317", "name": "C0037317#ent", "pos": [21, 22]}}
{"token": ["While", "SIN-1", "did", "not", "affect", "the", "insulin", "receptor", "protein", "and", "tyrosine", "phosphorylation", "it", "reduced", "the", "C1334140#ent", "<e1>", "IRS-1", ")", "protein", "level", ",", "and", "IRS-1", "associated", "phosphatidylinositol-3", "kinase", "C0919338#ent", "<e2>", "activity", "."], "h": {"id": "C1334140", "name": "C1334140#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0919338", "name": "C0919338#ent", "pos": [27, 28]}}
{"token": ["Lamivudine", "has", "recently", "received", "approval", "for", "clinical", "use", "chronic", "human", "infection", ",", "and", "both", "PCV", "and", "PMEA", "have", "undergone", "clinical", "trials", "C0019163#ent", "<e1>", "in", "their", "respective", "prodrug", "forms", "famciclovir", "and", "C0540694#ent", "<e2>", "bis-(POM)-PMEA", "]", ")", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [21, 22]}, "relation": "may_be_prevented_by", "t": {"id": "C0540694", "name": "C0540694#ent", "pos": [30, 31]}}
{"token": ["The", "role", "of", "C0009014#ent", "<e1>", "in", "blocking", "withdrawal-induced", "symptoms", "in", "patients", "with", "C0040517#ent", "<e2>", "treated", "with", "long-term", "neuroleptics", "is", "discussed", "from", "a", "clinical", "and", "neurobiological", "perspective", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [12, 13]}}
{"token": ["We", "examined", "the", "effects", "of", "C0700483#ent", "<e1>", "on", "cholesterol", "and", "C2917673#ent", "<e2>", "homeostatic", "mechanisms", "in", "a", "primary", "rat", "hepatocyte", "(", "PRH", ")", "culture", "model"], "h": {"id": "C0700483", "name": "C0700483#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2917673", "name": "C2917673#ent", "pos": [10, 11]}}
{"token": ["injection", "of", "C3536766#ent", "<e1>", "the", "release", "of", "C1416902#ent", "<e2>", "activity", "was", "only", "half", "as", "great", "as", "with", "heparin", "and", "the", "increase", "in", "plasma", "FFA", "was", "significantly", "lower", "."], "h": {"id": "C3536766", "name": "C3536766#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [7, 8]}}
{"token": ["We", "identified", "three", "C1842747#ent", "<e1>", "transcripts", "as", "C0165519#ent", "<e2>", "MMP-9", ")", ",", "creatine", "kinase", "and", "the", "alpha1", "(", "I", ")", "polypeptide", "chain", "(", "COL1A1", ")", "of", "type", "I", "collagen"], "h": {"id": "C1842747", "name": "C1842747#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0165519", "name": "C0165519#ent", "pos": [7, 8]}}
{"token": ["This", "pilot", "study", "performed", "to", "determine", "whether", "any", "clinically", "meaningful", "interaction", "between", "C0074554#ent", "<e1>", "and", "folic", "acid/vitamin", "C1417635#ent", "<e2>", "exists", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417635", "name": "C1417635#ent", "pos": [17, 18]}}
{"token": ["The", "clinical", "phenotype", "similar", "to", "that", "described", "with", "mutations", "in", "C1413404#ent", "<e1>", ",", "suggesting", "that", "mutations", "in", "these", "two", "C0599220#ent", "<e2>", "lead", "to", "similar", "functional", "alterations", "of", "the", "nAChR."], "h": {"id": "C1413404", "name": "C1413404#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [19, 20]}}
{"token": ["Studies", "provided", "evidence", "that", "the", "protein", "coded", "by", "C1413404#ent", "<e1>", "is", "one", "of", "the", "most", "abundant", "C0599220#ent", "<e2>", "of", "the", "neuronal", "nicotinic", "acetylcholine", "receptors", "mammalian", "brains", ",", "and", "mutations", "of", "C1413404#ent", "<e1>", "seem", "to", "cause", "neuronal", "excitation"], "h": {"id": "C1413404", "name": "C1413404#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [16, 17]}}
{"token": ["Nitric", "oxide", "NO", ")", "produced", "by", "C0907532#ent", "<e1>", "eNOS", ")", "mediates", "endothelium-dependent", "vasodilation", "C0016018#ent", "<e2>"], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [13, 14]}}
{"token": ["Nitric", "oxide", "NO", ")", "produced", "by", "C0907532#ent", "<e1>", "eNOS", ")", "represents", "an", "C0016018#ent", "<e2>", "and", "anti-atherosclerotic", "principle", "in", "the", "vasculature", "."], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [12, 13]}}
{"token": ["A", "library", "of", "monoclonal", "antibodies", "K-12", "Escherichia", "coli", "pyruvate", "dehydrogenase", "complex", "(", "C0034345#ent", "<e1>", ")", "and", "its", "C0034342#ent", "<e2>", "EC", "1.2.4.1", ";", "E1", ")", "subunit", "is", "reported", "."], "h": {"id": "C0034345", "name": "C0034345#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [17, 18]}}
{"token": ["C0076110#ent", "<e1>", "is", "also", "effective", "against", "C0040262#ent", "<e2>", "vaginal", "candidosis", "but", "only", "topically", "."], "h": {"id": "C0076110", "name": "C0076110#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040262", "name": "C0040262#ent", "pos": [6, 7]}}
{"token": ["Temperatures", "of", "22", "patients", "treated", "with", "C0040233#ent", "<e1>", ",", "20", "mg", "daily", ",", "in", "the", "acute", "phase", "C0027051#ent", "<e2>", "were", "compared", "to", "temperatures", "of", "22", "patients", "not", "receiving", "C0040233#ent", "<e1>", "treatment", "."], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0040233", "name": "C0040233#ent", "pos": [6, 7]}}
{"token": ["These", "data", "suggest", "that", "RAFTK", "itself", "is", "sufficient", "for", "C2348445#ent", "<e1>", "phosphorylation", ",", "whereas", "a", "cooperation", "between", "RAFTK", "and", "C0282625#ent", "<e2>", "required", "for", "the", "complete", "phosphorylation", "of", "p130(Cas", ")", "."], "h": {"id": "C2348445", "name": "C2348445#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [19, 20]}}
{"token": ["The", "involvement", "of", "two", "active", "site", "of", "C0054755#ent", "<e1>", "binding", "a", "C1418370#ent", "<e2>", "Ascaris", "was", "studied", "."], "h": {"id": "C0054755", "name": "C0054755#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418370", "name": "C1418370#ent", "pos": [11, 12]}}
{"token": ["C1706544#ent", "<e1>", "was", "strongly", "expressed", "by", "hepatocytes", "from", "control", "patients", "with", "C0019158#ent", "<e2>"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [11, 12]}}
{"token": ["C0050465#ent", "<e1>", "has", "been", "used", "as", "an", "efficient", "inhibitor", "of", "the", "C0068355#ent", "<e2>", "its", "mechanism", "of", "inhibition", "is", "linked", "to", "prior", "activation", "through", "the", "action", "of", "peroxidases", "."], "h": {"id": "C0050465", "name": "C0050465#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0068355", "name": "C0068355#ent", "pos": [11, 12]}}
{"token": ["Papain", ",", "trypsin", ",", "pepsin", "A", "Staphylococcus", "aureus", "V8", "protease", "C1413511#ent", "<e1>", "but", "not", "C3887938#ent", "<e2>", "."], "h": {"id": "C1413511", "name": "C1413511#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3887938", "name": "C3887938#ent", "pos": [14, 15]}}
{"token": ["Chloroquine", "appears", "to", "be", "a", "good", "alternative", "to", "C0040263#ent", "<e1>", "for", "the", "treatment", "of", "paediatric", "patients", "with", "C0017536#ent", "<e2>", "."], "h": {"id": "C0040263", "name": "C0040263#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0017536", "name": "C0017536#ent", "pos": [17, 18]}}
{"token": ["C1334435#ent", "<e1>", "production", "was", "cap", "dependent", "C0035685#ent", "<e2>", "dependent", "and", "increased", "following", "transfection", "of", "Huh-7", "cells", "."], "h": {"id": "C1334435", "name": "C1334435#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035685", "name": "C0035685#ent", "pos": [6, 7]}}
{"token": ["Interestingly", ",", "PDE4B", "was", "significantly", "more", "sensitive", "to", "inhibition", "by", "both", "C0073561#ent", "<e1>", "and", "diazepam", "than", "the", "C1418420#ent", "<e2>", "subtype", "."], "h": {"id": "C0073561", "name": "C0073561#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418420", "name": "C1418420#ent", "pos": [17, 18]}}
{"token": ["The", "C1511576#ent", "<e1>", "include", "the", "Ink4", "family", "(", "C0249219#ent", "<e2>", ",", "p16Ink4a", ",", "p18Ink4c", ",", "p19Ink4d", ")", "and", "the", "KIP", "family", "(", "p21Cip1", "and", "p27Kip1", ")", "."], "h": {"id": "C1511576", "name": "C1511576#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0249219", "name": "C0249219#ent", "pos": [8, 9]}}
{"token": ["Since", "C0052527#ent", "<e1>", "mice", "develop", "hypertension", "C1414406#ent", "<e2>", "appears", "to", "be", "an", "essential", "enzyme", "in", "the", "control", "of", "blood", "pressure", "degradation", "of", "AngII", "."], "h": {"id": "C0052527", "name": "C0052527#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414406", "name": "C1414406#ent", "pos": [6, 7]}}
{"token": ["Endocrinologists", "were", "not", "included", "in", "the", "multidisciplinary", "working", "groups", "prepared", "two", "recent", "reports", "on", "chronic", "fatigue", "syndrome", "despite", "its", "unequalled", "clinical", "overlap", "C0001403#ent", "<e1>", "which", "is", "a", "classic", "C0014130#ent", "<e2>"], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [28, 29]}}
{"token": ["The", "effects", "of", "three", "opiate", "analgesics", "isolated", "from", "C0886287#ent", "<e1>", ",", "on", "the", "C0311727#ent", "<e2>", "been", "studied", "."], "h": {"id": "C0886287", "name": "C0886287#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0311727", "name": "C0311727#ent", "pos": [13, 14]}}
{"token": ["Recently", ",", "a", "novel", "C1332828#ent", "<e1>", "C0960580#ent", "<e2>", "*", "17", ")", ",", "associated", "with", "metabolism", "of", "C0960580#ent", "<e2>", "substrates", ",", "was", "described", "."], "h": {"id": "C1332828", "name": "C1332828#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [6, 7]}}
{"token": ["Our", "objective", "was", "to", "evaluate", "the", "relationship", "between", "the", "disposition", "of", "sertraline", "and", "the", "presence", "of", "the", "C1332828#ent", "<e1>", "to", "define", "the", "contribution", "of", "cytochrome", "P450", "2C19", "C0960580#ent", "<e2>", ")", "to", "sertraline", "N-demethylation", "."], "h": {"id": "C1332828", "name": "C1332828#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [27, 28]}}
{"token": ["Myosin", "light", "chain", "kinase", "MYLK", ")", "is", "a", "C1415740#ent", "<e1>", "in", "regulation", "of", "airway", "C0004096#ent", "<e2>", "and", "other", "activities", "relevant", "to", "asthma", "."], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [14, 15]}}
{"token": ["Using", "C1517755#ent", "<e1>", "we", "have", "identified", "that", "C0089795#ent", "<e2>", "PI-PLC", ")", ",", "but", "not", "phosphatidylcholine", "(PC)-phospholipase", "C", "PC-PLC", ")", "nor", "PC-phospholipase", "D", "PC-PLD", ")", ",", "was", "required", "for", "LPS-induced", "NO", "production", "."], "h": {"id": "C1517755", "name": "C1517755#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0089795", "name": "C0089795#ent", "pos": [7, 8]}}
{"token": ["The", "inhibitory", "activity", "of", "destruxin", "B", "weaker", "than", "that", "of", "C0052919#ent", "<e1>", "folimycin", ",", "well", "known", "C0003015#ent", "<e2>", "V-ATPase", ",", "when", "compared", "at", "the", "same", "molar", "concentration", "."], "h": {"id": "C0052919", "name": "C0052919#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [16, 17]}}
{"token": ["C0036117#ent", "<e1>", "expresses", "two", "flagellin", "proteins", "C1332667#ent", "<e2>", "and", "FljB.", "We", "purified", "C1332667#ent", "<e2>", "and", "FljB", "and", "examined", "the", "ability", "of", "the", "Salmonella", "flagellins", "activate", "the", "NF-kappaB", "transcription", "factor", "human", "embryonic", "kidney", "cells"], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332667", "name": "C1332667#ent", "pos": [6, 7]}}
{"token": ["C0036117#ent", "<e1>", "possess", "two", "genes", ",", "C1332667#ent", "<e2>", "and", "fljB", ",", "that", "encode", "flagellin", "proteins"], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332667", "name": "C1332667#ent", "pos": [6, 7]}}
{"token": ["Strategies", "for", "treatment", "with", "oral", "C1263960#ent", "<e1>", ":", "Targeting", "fasting", "C0475718#ent", "<e2>", ",", "targeting", "postprandial", "C0475718#ent", "<e2>", ",", "minimising", "cost", "therapy", "minimising", "weight", "gain", "minimising", "patient", "effort", "strategies", "."], "h": {"id": "C1263960", "name": "C1263960#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0475718", "name": "C0475718#ent", "pos": [10, 11]}}
{"token": ["The", "main", "toxicity", "of", "C0671137#ent", "<e1>", "was", "haematological", "(", "C0040034#ent", "<e2>", ")", "and", "the", "most", "common", "non-haematological", "adverse", "event", "was", "nausea", "."], "h": {"id": "C0671137", "name": "C0671137#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [9, 10]}}
{"token": ["The", "C1955862#ent", "<e1>", "activated", "by", "C0010531#ent", "<e2>", "but", "not", "by", "10(-4", ")", "M", "GTP", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [5, 6]}}
{"token": ["Under", "C0341703#ent", "<e1>", ",", "animals", "develop", "food", "anticipatory", "activity", "(", "C2828026#ent", "<e2>", ")", ",", "characterized", "by", "arousal", "and", "increased", "locomotion", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2828026", "name": "C2828026#ent", "pos": [10, 11]}}
{"token": ["Fractionation", "of", "patient", "mononuclear", "cells", "discontinuous", "density", "gradient", "centrifugation", "that", "large", "granular", "lymphocytes", "C0024054#ent", "<e1>", ")", "were", "the", "main", "C0127400#ent", "<e2>", "of", "the", "NK", "activity", "in", "asthmatics", "."], "h": {"id": "C0024054", "name": "C0024054#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [19, 20]}}
{"token": ["Since", "November", "1993", ",", "C0020402#ent", "<e1>", "has", "been", "used", "in", "our", "clinic", "for", "preventing", "C0033117#ent", "<e2>", "in", "patients", "with", "stuttering", "or", "major", "attacks", "are", "still", "capable", "of", "achieving", "intercourse", "on", "demand", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033117", "name": "C0033117#ent", "pos": [14, 15]}}
{"token": ["In", "a", "three-way", "cross-over", "study", "12", "healthy", "volunteers", "single", "doses", "of", "C0538013#ent", "<e1>", "a", "highly", "specific", "C1319313#ent", "<e2>", ",", "25", "and", "100", "mg", ",", "were", "compared", "with", "placebo", "."], "h": {"id": "C0538013", "name": "C0538013#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1319313", "name": "C1319313#ent", "pos": [16, 17]}}
{"token": ["Heavy", "HIOL", "was", "noted", "in", "C282Y", "homozygotes", "and", "1", "patient", "with", "C0023890#ent", "<e1>", "without", "either", "C3469186#ent", "<e2>", "mutation", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C3469186", "name": "C3469186#ent", "pos": [15, 16]}}
{"token": ["Recent", "investigations", "show", "that", "in", "mouse", "brain", "slices", ",", "C0031507#ent", "<e1>", "inhibited", "elevations", "of", "cyclic", "GMP", "cyclic", "AMP", "by", "C0029904#ent", "<e2>", "or", "veratridine", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [19, 20]}}
{"token": ["Amine", "local", "anesthetics", "reversed", "the", "inhibition", "by", "both", "compounds", "whereas", "the", "anticonvulsant", "drugs", "as", "carbamazepine", "and", "C0031507#ent", "<e1>", "reversed", "the", "effects", "of", "aconitine", "but", "not", "C0029904#ent", "<e2>", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [25, 26]}}
{"token": ["The", "other", "cases", "of", "C0006060#ent", "<e1>", "all", "the", "cases", "of", "murine", ",", "C0152061#ent", "<e2>", "and", "scrub", "typhus", "in", "tourists", "who", "had", "recently", "come", "back", "from", "countries", "where", "rickettsial", "morbidity", "persists", "."], "h": {"id": "C0006060", "name": "C0006060#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0152061", "name": "C0152061#ent", "pos": [12, 13]}}
{"token": ["However", ",", "C0011847#ent", "<e1>", "caused", "an", "increase", "in", "the", "half-life", "of", "C3853562#ent", "<e2>", "mRNA", "from", "5", "h", "in", "normal", "hepatocytes", "to", "8", "h", "in", "diabetic", "ones", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3853562", "name": "C3853562#ent", "pos": [11, 12]}}
{"token": ["Neither", "C0011847#ent", "<e1>", "nor", "insulin", "supplementation", "diabetic", "rats", "altered", "the", "transcription", "rate", "of", "C3853562#ent", "<e2>"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3853562", "name": "C3853562#ent", "pos": [13, 14]}}
{"token": ["A", "regulatory", "element", "contains", "two", "binding", "sites", "the", "liganded", "Ah", "receptor", "a", "truncated", "C3252639#ent", "<e1>", "promoter", "suffices", "to", "direct", "C0919425#ent", "<e2>", ",", "Ah", "receptor-dependent", "transcription", "in", "vitro"], "h": {"id": "C3252639", "name": "C3252639#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [19, 20]}}
{"token": ["Spectral", ",", "electrophoretic", ",", "immunochemical", "and", "biocatalytic", "properties", "of", "the", "purified", "C3252639#ent", "<e1>", "suggested", "that", "it", "is", "the", "C0919425#ent", "<e2>", "in", "the", "L.", "saliens", "liver", "."], "h": {"id": "C3252639", "name": "C3252639#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [18, 19]}}
{"token": ["To", "report", "the", "safety", "and", "efficacy", "of", "leflunomide", "(", "LEF", ")", "in", "combination", "with", "infliximab", "(", "C1415066#ent", "<e1>", ")", "for", "the", "treatment", "of", "C0038013#ent", "<e2>"], "h": {"id": "C1415066", "name": "C1415066#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [23, 24]}}
{"token": ["The", "neoplastic", "cells", "B-cell", "markers", "usually", "C0376515#ent", "<e1>", "and", "are", "negative", "for", "CD5", ",", "C1706431#ent", "<e2>", ",", "and", "bcl-6", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706431", "name": "C1706431#ent", "pos": [14, 15]}}
{"token": ["Unexpectedly", ",", "the", "effects", "of", "ET-3", "and", "of", "sarafotoxins", "b", "and", "c", "(", "SRTX-b", "and", "C0259475#ent", "<e1>", ")", "on", "this", "pathway", "differ", "from", "that", "of", "C3273436#ent", "<e2>", "."], "h": {"id": "C0259475", "name": "C0259475#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [25, 26]}}
{"token": ["C0259475#ent", "<e1>", "was", "as", "potent", "as", "C3273436#ent", "<e2>", ",", "while", "BQ", "123", "did", "not", "affect", "ET-1-induced", "growth", "inhibition", "."], "h": {"id": "C0259475", "name": "C0259475#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [6, 7]}}
{"token": ["New", "dielectric", "spectroscopy", "results", "are", "reported", "for", "propylene", "carbonate", "C3811118#ent", "<e1>", ")", ",", "glycerol", ",", "and", "C0012789#ent", "<e2>", ",", "measured", "at", "very", "high", "(", "1.8", "GPa", ")", "pressure", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012789", "name": "C0012789#ent", "pos": [16, 17]}}
{"token": ["Genetic", "evidence", "that", "while", "C0529196#ent", "<e1>", "is", "responsible", "for", "the", "shedding", "of", "C1332075#ent", "<e2>", ",", "both", "C0529196#ent", "<e1>", "and", "ADAM10", "can", "act", "on", "Dsg-2", "."], "h": {"id": "C0529196", "name": "C0529196#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332075", "name": "C1332075#ent", "pos": [12, 13]}}
{"token": ["These", "data", "suggest", "that", "COX-2", "C4284124#ent", "<e1>", "mice", "with", "intact", "renal", "function", "primary", "hyperparathyroidism", "and", "that", "effects", "of", "increased", "C1705340#ent", "<e2>", "and", "1,25-dihydroxyvitamin", "D(3", ")", "to", "increase", "bone", "turnover", "compensate", "for", "the", "absence", "of", "COX-2", "."], "h": {"id": "C4284124", "name": "C4284124#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [19, 20]}}
{"token": ["However", ",", "co-transfected", "C3539876#ent", "<e1>", "activity", "of", "the", "385", "bp", "minimal", "P2X1", "promoter", "a", "C1420295#ent", "<e2>", "manner", "."], "h": {"id": "C3539876", "name": "C3539876#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "when", "the", "EAC1", "cells", ",", "which", "were", "carrying", "C1418485#ent", "<e1>", "on", "the", "EAs", ",", "treated", "with", "C1419141#ent", "<e2>", "were", "exposed", "to", "serum", ",", "hemolysis", "decreased", "in", "a", "C1419141#ent", "<e2>", "dose-dependent", "manner", "."], "h": {"id": "C1418485", "name": "C1418485#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419141", "name": "C1419141#ent", "pos": [18, 19]}}
{"token": ["C0042842#ent", "<e1>", "a", "significant", "decrease", "in", "superoxide", "dismutase", "glutathione", "peroxidase", "C1260386#ent", "<e2>", "levels", "."], "h": {"id": "C0042842", "name": "C0042842#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [10, 11]}}
{"token": ["C0042842#ent", "<e1>", "not", "alter", "enzyme", "activities", "enhanced", "the", "skin", "reserve", "of", "C1260386#ent", "<e2>", ",", "which", "appeared", "to", "be", "the", "reason", "for", "a", "decrease", "in", "endogenous", "lipid", "peroxidation"], "h": {"id": "C0042842", "name": "C0042842#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [11, 12]}}
{"token": ["We", "focus", "on", "the", "fate", "and", "the", "role", "of", "E-cadherin", ",", "the", "main", "classical", "C1413274#ent", "<e1>", "expressed", "in", "epithelial", "cells", "in", "the", "C1418401#ent", "<e2>", "in", "enterocytes", "by", "loss", "of", "anchorage", "the", "extracellular", "matrix", "anoikis", ")", "."], "h": {"id": "C1413274", "name": "C1413274#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [22, 23]}}
{"token": ["Even", "though", "C3887650#ent", "<e1>", "is", "generally", "considered", "the", "most", "typical", "metabolic", "bone", "disease", "C0024523#ent", "<e2>", "bone", "biopsy", "that", "osteoporosis", "was", "the", "prominent", "histologic", "feature", "in", "this", "patient", "."], "h": {"id": "C3887650", "name": "C3887650#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", ",", "we", "describe", "the", "determination", "of", "levels", "of", "IL-12", ",", "IL-10", "and", "C1332691#ent", "<e1>", "in", "the", "sera", "of", "Cuban", "patients", "hospitalised", "with", "C0011311#ent", "<e2>", "Dengue", "haemorrhagic", "fever"], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011311", "name": "C0011311#ent", "pos": [26, 27]}}
{"token": ["The", "analysis", "of", "pharmacological", "action", "C0065099#ent", "<e1>", "and", "C0031977#ent", "<e2>", "in", "cardiogenic", "stress", "proves", "more", "positive", "effect", "of", "C0065099#ent", "<e1>", "upon", "dynamics", "of", "myocardial", "infarction", "peroxide", "lipid", "oxidation", "process", "humoral", "and", "cellular", "immunity", "indexes", "."], "h": {"id": "C0031977", "name": "C0031977#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0065099", "name": "C0065099#ent", "pos": [5, 6]}}
{"token": ["Distinctive", "C0029166#ent", "<e1>", "in", "a", "number", "of", "rare", "PIDs", "(", "e.g.", ",", "C0272236#ent", "<e2>", "Di", "George", "syndrome", "and", "in", "syndromes", "characterized", "by", "spondyloepiphyseal", "dysplasia"], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0272236", "name": "C0272236#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", "we", "used", "serotype", "1", "C1412056#ent", "<e1>", "to", "express", "mouse", "C0023521#ent", "<e2>", "under", "the", "control", "of", "the", "human", "cytomegalovirus", "promoter", "."], "h": {"id": "C1412056", "name": "C1412056#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023521", "name": "C0023521#ent", "pos": [12, 13]}}
{"token": ["Myeloid-related", "protein", "C1825410#ent", "<e1>", ")", "8", "and", "MRP14", ",", "two", "members", "of", "the", "C1335802#ent", "<e2>", "expressed", "in", "myelomonocytic", "cells", "have", "been", "ascribed", "some", "extracellular", "functions", "e.g.", "antimicrobial", ",", "cytostatic", ",", "and", "chemotactic", "activities"], "h": {"id": "C1825410", "name": "C1825410#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335802", "name": "C1335802#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "exponentially", "growing", "cells", "of", "Escherichia", "coli", "membrane-binding", "drugs", "such", "as", "chlorpromazine", "(", "C1413693#ent", "<e1>", ")", "and", "procaine", "resulted", "in", "an", "induction", "of", "C1743497#ent", "<e2>", "Mn-SOD", ")", "."], "h": {"id": "C1413693", "name": "C1413693#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [24, 25]}}
{"token": ["The", "ATP", "increase", "was", "largely", "inhibited", "by", "either", "30", "muM", "5-nitro-2-(3-phenylpropylamino", ")", "C1161334#ent", "<e1>", "NPPB", ")", "or", "10", "muM", "carbenoxolone", "(", "C1413156#ent", "<e2>", ")", "."], "h": {"id": "C1161334", "name": "C1161334#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413156", "name": "C1413156#ent", "pos": [21, 22]}}
{"token": ["The", "other", "3", "chemical", "agents", "that", "is", ",", "C0040096#ent", "<e1>", ",", "glutaraldehyde", ",", "and", "C0063779#ent", "<e2>", ",", "did", "not", "increase", "the", "levels", "of", "chromosome", "aberrations"], "h": {"id": "C0040096", "name": "C0040096#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0063779", "name": "C0063779#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", ",", "we", "show", "that", "C3543431#ent", "<e1>", "interacts", "with", "C1448657#ent", "<e2>", ",", "hRad1", "and", "hHus1", "as", "individual", "proteins", "and", "as", "a", "complex", "."], "h": {"id": "C3543431", "name": "C3543431#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1448657", "name": "C1448657#ent", "pos": [11, 12]}}
{"token": ["Sequence", "analysis", "84", "%", "amino", "acid", "to", "a", "putative", "cyclodextrin", "glycosyltransferase", "Nostoc", "sp.", "PCC", "7120", "the", "C0017337#ent", "<e1>", "was", "therefore", "termed", "C0006698#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0006698", "name": "C0006698#ent", "pos": [21, 22]}}
{"token": ["Administration", "of", "C0244821#ent", "<e1>", "for", "7", "days", "increased", "C1260386#ent", "<e2>", ",", "catalase", "and", "SOD", "activities", "in", "the", "striatum", "and", "protected", "striatal", "dopaminergic", "neurons", "6-hydroxydopamine", "(", "6-OHDA", ")", "in", "mice", "."], "h": {"id": "C0244821", "name": "C0244821#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [8, 9]}}
{"token": ["C0006309#ent", "<e1>", "is", "a", "C0004623#ent", "<e2>", "can", "last", "years", "if", "not", "treated", "properly", "."], "h": {"id": "C0006309", "name": "C0006309#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [4, 5]}}
{"token": ["In", "the", "presence", "of", "3-chloro-1-hydroxypropanone", ",", "an", "inhibitor", "of", "stage", "2", "the", "glycolytic", "pathway", "the", "triosephosphates", "were", "metabolized", "faster", ",", "produced", "less", "C0016755#ent", "<e1>", ",", "fructose", "6-phosphate", "glucose", "6-phosphate", "but", "not", "C0017868#ent", "<e2>", "or", "glycerol", "3-phosphate"], "h": {"id": "C0016755", "name": "C0016755#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [31, 32]}}
{"token": ["Tissue", "organization", "Drosophila", "is", "regulated", "by", "the", "core", "planar", "cell", "polarity", "C0031381#ent", "<e1>", ")", "proteins", "Frizzled", ",", "Dishevelled", ",", "C1424690#ent", "<e2>", ",", "Van", "Gogh", "and", "Flamingo", "."], "h": {"id": "C0031381", "name": "C0031381#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1424690", "name": "C1424690#ent", "pos": [19, 20]}}
{"token": ["Corresponding", "with", "the", "in", "vitro", "data", ",", "xenograft", "tumors", "generated", "from", "the", "resistant", "cells", "not", "respond", "to", "gemcitabine", "but", "were", "growth", "inhibited", "when", "C0765273#ent", "<e1>", "was", "added", "to", "the", "C0304497#ent", "<e2>"], "h": {"id": "C0765273", "name": "C0765273#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0304497", "name": "C0304497#ent", "pos": [29, 30]}}
{"token": ["Therefore", ",", "we", "propose", "that", "Ras", "stabilizes", "C1420626#ent", "<e1>", "by", "promoting", "the", "formation", "of", "p21-cyclin", "D1", "complexes", "that", "prevent", "C1420626#ent", "<e1>", "association", "with", ",", "and", "subsequent", "degradation", "by", ",", "the", "C0208355#ent", "<e1>"], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0208355", "name": "C0208355#ent", "pos": [30, 31]}}
{"token": ["Most", "successful", "as", "treatment", "of", "dermatophytoses", "at", "extra-intertriginous", "sites", "and", "treatment", "of", "C0032024#ent", "<e1>", "manifestation", "of", "C0006840#ent", "<e2>", "were", "not", "affected", "."], "h": {"id": "C0032024", "name": "C0032024#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "suggest", "that", "cigarette", "smoking", "C0020445#ent", "<e1>", "to", "different", "patterns", "of", "C0264683#ent", "<e2>"], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0264683", "name": "C0264683#ent", "pos": [12, 13]}}
{"token": ["In", "vitro", "formation", "of", "CE", "species", "in", "plasma", "by", "lecithin-cholesterol", "acyltransferase", "C1416804#ent", "<e1>", ")", "showed", "an", "increased", "formation", "of", "20:5", "CE", "not", "22:6", "CE", ",", "indicating", "that", "C2348308#ent", "<e2>", "is", "a", "poor", "substrate", "C1416804#ent", "<e1>", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [11, 12]}}
{"token": ["The", "study", "is", "based", "on", "371", "cerebrospinal", "fluid", "CSF", ")", "samples", "and", "324", "serum", "samples", "from", "40", "patients", "with", "C0010678#ent", "<e1>", "(", "NC", ")", "submitted", "to", "treatment", "with", "C0032911#ent", "<e2>", "."], "h": {"id": "C0010678", "name": "C0010678#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [28, 29]}}
{"token": ["C0038160#ent", "<e1>", "present", "on", "admission", "or", "C0205721#ent", "<e2>", ",", "occurred", "in", "2.6", "%", "of", "patients", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0205721", "name": "C0205721#ent", "pos": [6, 7]}}
{"token": ["C3539598#ent", "<e1>", "(", "10(-8", ")", "M", ")", "markedly", "suppressed", "the", "vasoconstrictor", "response", "C0045733#ent", "<e2>", ",", "but", "did", "not", "affect", "vasodilator", "responses"], "h": {"id": "C3539598", "name": "C3539598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0045733", "name": "C0045733#ent", "pos": [12, 13]}}
{"token": ["C0007427#ent", "<e1>", "an", "estrogen", "(", "17", "C0014914#ent", "<e2>", ",", "E2)-inducible", "lysosomal", "protease", "."], "h": {"id": "C0007427", "name": "C0007427#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014914", "name": "C0014914#ent", "pos": [6, 7]}}
{"token": ["Sixteen", "had", "C3494506#ent", "<e1>", ",", "7", "SHP", "and", "8", "C1705396#ent", "<e2>", "."], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705396", "name": "C1705396#ent", "pos": [9, 10]}}
{"token": ["Two", "C0907533#ent", "<e1>", "expressed", "proteins", ",", "B4", "and", "C1864824#ent", "<e2>", ",", "were", "identified", "as", "pseudouridine", "synthase", "elongation", "factor", "P", "respectively", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1864824", "name": "C1864824#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "suggest", "that", "overexpression", "of", "C0162745#ent", "<e1>", "and", "-3", "and", "C1335642#ent", "<e2>", "and", "-3", "is", "induced", "during", "melanoma", "progression", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335642", "name": "C1335642#ent", "pos": [11, 12]}}
{"token": ["Using", "this", "technique", ",", "we", "measured", "Abeta", "secreted", "from", "COS7", "cells", "transiently", "transfected", "with", "APP", "C0025250#ent", "<e1>", "in", "the", "presence", "of", "LiCl", ",", "a", "potent", "C0033640#ent", "<e2>", "inhibitor", "."], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [25, 26]}}
{"token": ["The", "measured", "activity", "of", "guaiacol", "peroxidase", "laccase", ",", "and", "C0007367#ent", "<e1>", "was", "increased", "when", "the", "mycelium", "was", "treated", "with", "C0017696#ent", "<e2>", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017696", "name": "C0017696#ent", "pos": [19, 20]}}
{"token": ["Xeroderma", "pigmentosum", "Cockayne's", "syndrome", "ataxia", "telangiectasia", "Fanconi", "anemia", "and", "C0268425#ent", "<e1>", "autosomal", "recessive", "diseases", "cellular", "defects", "the", "ability", "to", "C1951340#ent", "<e2>", "DNA", "damage"], "h": {"id": "C0268425", "name": "C0268425#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1951340", "name": "C1951340#ent", "pos": [19, 20]}}
{"token": ["Fourteen", "days", "after", "C1705969#ent", "<e1>", "exposure", ",", "CYP1A1", "protein", "activity", "were", "measured", "by", "Western", "blot", "C0059735#ent", "<e2>", "respectively", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [15, 16]}}
{"token": ["C1705969#ent", "<e1>", "exposure", "significantly", "inhibited", "C0059735#ent", "<e2>", "activity", "in", "a", "dose-responsive", "manner", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [5, 6]}}
{"token": ["These", "seven", "infants", "are", "affected", "by", "a", "C0026848#ent", "<e1>", "clinically", "resembling", "C1415994#ent", "<e2>", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415994", "name": "C1415994#ent", "pos": [11, 12]}}
{"token": ["5-HT", ",", "8-OH-DPAT", "and", "DOI", "significantly", "increased", "basal", "C1704793#ent", "<e1>", "release", ",", "an", "effect", "which", "was", "antagonized", "by", "C2936517#ent", "<e2>"], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2936517", "name": "C2936517#ent", "pos": [18, 19]}}
{"token": ["Three", "to", "four", "C3536835#ent", "<e1>", "inactivating", "enzymes", "were", "detected", "in", "cell-free", "extracts", "clinical", "strains", "C0085423#ent", "<e2>", "Pseudomonas", ",", "Escherichia", ",", "Serratia", ",", "Enterobacter", "and", "Klebsiella", "and", "in", "cell-free", "extracts", "their", "transconjugants", "."], "h": {"id": "C3536835", "name": "C3536835#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [14, 15]}}
{"token": ["C0055461#ent", "<e1>", "may", "reduce", "the", "immunogenicity", "of", "the", "C0007222#ent", "<e2>", "103-HgR", "component", "and", "proguanil", "may", "reduce", "the", "immunogenicity", "of", "the", "Ty21a", "component", "."], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [8, 9]}}
{"token": ["C0072916#ent", "<e1>", "is", "a", "newer", "C1268865#ent", "<e2>", "side", "effects", "the", "central", "nervous", "system", "might", "be", "a", "superior", "treatment", "."], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1268865", "name": "C1268865#ent", "pos": [5, 6]}}
{"token": ["C0376532#ent", "<e1>", "BRE", ")", "has", "an", "excellent", "prognosis", "for", "C0036572#ent", "<e2>", ",", "but", "recent", "research", "has", "raised", "concerns", "using", "cognition", "as", "an", "outcome", "measure"], "h": {"id": "C0376532", "name": "C0376532#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}}
{"token": ["The", "authors", "describe", "a", "paradoxical", "reaction", "lamotrigine", "(", "LTG", ")", "treatment", "in", "a", "patient", "with", "C0376532#ent", "<e1>", "by", "seizure", "deterioration", "the", "appearance", "of", "new", "C0036572#ent", "<e2>", "and", "transient", "cognitive", "impairment"], "h": {"id": "C0376532", "name": "C0376532#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [24, 25]}}
{"token": ["Electrophoretic", "and", "Western", "blot", "studies", "conducted", "on", "C0009325#ent", "<e1>", "fractions", "extracted", "from", "C3840276#ent", "<e2>", "cuttlefish", ")", "cartilage", "using", "a", "modified", "salt", "precipitation", "method", "developed", "for", "the", "isolation", "of", "vertebrate", "collagens"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3840276", "name": "C3840276#ent", "pos": [12, 13]}}
{"token": ["The", "risk", "factors", "outcomes", "of", "C0010340#ent", "<e1>", "patients", "with", "C0032326#ent", "<e2>", "IP", ")", "have", "not", "been", "studied", "in", "a", "large", "unselected", "intensive", "care", "unit", "ICU", ")", "population", "."], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032326", "name": "C0032326#ent", "pos": [9, 10]}}
{"token": ["Inhaled", "NO", "thus", "has", "a", "potential", "therapeutic", "role", "as", "a", "selective", "C0042402#ent", "<e1>", "patients", "with", "interstitial", "pulmonary", "fibrosis", "C0238074#ent", "<e2>"], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0238074", "name": "C0238074#ent", "pos": [18, 19]}}
{"token": ["The", "removal", "of", "an", "intrauterine", "device", "a", "woman", "with", "severe", "intractable", "C0042164#ent", "<e1>", "associated", "with", "remission", "of", "the", "C0015397#ent", "<e2>"], "h": {"id": "C0042164", "name": "C0042164#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [18, 19]}}
{"token": ["This", "response", "was", "inhibited", "by", "C1451270#ent", "<e1>", "and", "nisoldipine", ",", "but", "not", "by", "propranolol", ",", "C0032912#ent", "<e2>", ",", "or", "pretreatment", "with", "pertussis", "toxin"], "h": {"id": "C1451270", "name": "C1451270#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [15, 16]}}
{"token": ["The", "effect", "of", "thrombin", "to", "stimulate", "phosphoinositide", "hydrolysis", "inhibited", "by", "C1451270#ent", "<e1>", ",", "but", "not", "by", "propranolol", ",", "C0032912#ent", "<e2>", ",", "or", "pretreatment", "with", "pertussis", "toxin"], "h": {"id": "C1451270", "name": "C1451270#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [18, 19]}}
{"token": ["In", "total", ",", "165", "Caucasian", "outpatients", "on", "stable", "maintenance", "warfarin", "treatment", "previously", "genotyped", "for", "CYP2C9", "were", "analysed", "for", "common", "polymorphisms", "in", "C1366370#ent", "<e1>", ",", "GGCX", "and", "C1428184#ent", "<e2>"], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1428184", "name": "C1428184#ent", "pos": [26, 27]}}
{"token": ["These", "bipolar", "cells", "serotonin", ",", "C0041491#ent", "<e1>", "histamine", ",", "gamma-amino-butyric", "acid", "GABA", ")", ",", "C0541392#ent", "<e2>", "proctolin", "or", "rhodopsin", "in", "various", "combinations", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0541392", "name": "C0541392#ent", "pos": [14, 15]}}
{"token": ["This", "suggests", "that", "the", "major", "very", "late", "activation", "Ag", "integrins", "during", "childhood", "may", "be", "alpha", "5", "beta", "1", "C1334087#ent", "<e1>", "with", "an", "alternate", "C1332790#ent", "<e2>"], "h": {"id": "C1334087", "name": "C1334087#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332790", "name": "C1332790#ent", "pos": [23, 24]}}
{"token": ["Sequence", "analysis", "that", "pss1", "+", "encodes", "an", "C1412821#ent", "<e1>", "ORF", ")", "of", "730amino", "C0815040#ent", "<e2>", "that", "is", "homologous", "to", "the", "HSP70", "family", "proteins"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [13, 14]}}
{"token": ["Sequence", "analysis", "the", "C1412821#ent", "<e1>", "two", "possible", "nuclear", "localization", "sequences", "several", "clusters", "of", "C0815040#ent", "<e2>", "including", "a", "continuous", "run", "of", "11", "glutamic", "acid", "residues"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [13, 14]}}
{"token": ["The", "C2828027#ent", "<e1>", "diagnosis", "was", "AML-M2", "in", "one", ",", "chronic", "myelomonocytic", "leukemia", "two", "and", "C2981142#ent", "<e2>", "excess", "of", "blasts", "in", "transformation", "in", "four", "cases", "."], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2981142", "name": "C2981142#ent", "pos": [14, 15]}}
{"token": ["According", "to", "the", "C2828027#ent", "<e1>", "classification", ",", "a", "diagnosis", "of", "C2981142#ent", "<e2>", "ring", "sideroblasts", "made", "."], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2981142", "name": "C2981142#ent", "pos": [10, 11]}}
{"token": ["According", "to", "C2828027#ent", "<e1>", "classification", ",", "5", "patients", "had", "C2981142#ent", "<e2>", "RA", ")", "."], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2981142", "name": "C2981142#ent", "pos": [9, 10]}}
{"token": ["The", "C1373060#ent", "<e1>", "Nomega-nitro-", "L-arginine", "L-NNA", ")", "also", "blocked", "the", "response", "to", "C0061355#ent", "<e2>", ",", "whereas", "L-arginine", "restored", "the", "response", "."], "h": {"id": "C1373060", "name": "C1373060#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0061355", "name": "C0061355#ent", "pos": [12, 13]}}
{"token": ["The", "possible", "explanations", "for", "the", "association", "of", "PHP", "type", "II", "C0020595#ent", "<e1>", "this", "patient", "with", "C0035334#ent", "<e2>", "discussed", "."], "h": {"id": "C0020595", "name": "C0020595#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [15, 16]}}
{"token": ["C0053827#ent", "<e1>", "similarly", "to", "propranolol", "and", "C0041030#ent", "<e2>", ",", "prolonged", "the", "refractory", "period", "in", "the", "atrial", "preparations", "starting", "with", "the", "concentration", "of", "10(-6", ")", "mol/l", "."], "h": {"id": "C0053827", "name": "C0053827#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041030", "name": "C0041030#ent", "pos": [6, 7]}}
{"token": ["This", "result", "indicates", "that", "the", "binding", "site", "C3810551#ent", "<e1>", "for", "each", "of", "these", "eight", "C0032594#ent", "<e2>", "different", "from", "the", "heparin-", "or", "dermatan", "sulfate-binding", "site"], "h": {"id": "C3810551", "name": "C3810551#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "in", "transfected", "HEK293", "cells", "functional", "and", "physical", "interactions", "CAIX", "and", "the", "parietal", "cell", "Cl(-)/HCO(3)(-", ")", "exchanger", "C1826361#ent", "<e1>", "or", "the", "putative", "Cl(-)/HCO(3)(-", ")", "exchanger", "C1422673#ent", "<e2>", "."], "h": {"id": "C1826361", "name": "C1826361#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1422673", "name": "C1422673#ent", "pos": [26, 27]}}
{"token": ["CAIX", "was", "coimmunoprecipitated", "with", "the", "coexpressed", "SLC4", "polypeptides", "AE1", ",", "C1826361#ent", "<e1>", ",", "and", "AE3", ",", "but", "not", "with", "C1422673#ent", "<e2>", "."], "h": {"id": "C1826361", "name": "C1826361#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1422673", "name": "C1422673#ent", "pos": [19, 20]}}
{"token": ["AF64A", "also", "irreversibly", "inhibited", "partially", "purified", "C0008415#ent", "<e1>", "acetylcholinesterase", "but", "not", "lactate", "dehydrogenase", "alcohol", "dehydrogenase", "carboxypeptidase", "A", "or", "chymotrypsinogen", ",", "C3540017#ent", "<e2>", "that", "do", "not", "use", "choline", "as", "a", "substrate", "or", "product", "."], "h": {"id": "C0008415", "name": "C0008415#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [20, 21]}}
{"token": ["Using", "degenerate", "primers", "on", "conserved", "protein", "sequences", "C0079941#ent", "<e1>", "we", "have", "found", "evidence", "for", "C2984191#ent", "<e2>", "expression", "at", "the", "blastocyst", "stage", "mouse", "preimplantation", "development", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2984191", "name": "C2984191#ent", "pos": [14, 15]}}
{"token": ["This", "suggests", "that", "the", "physiological", "roles", "of", "C1705543#ent", "<e1>", "are", "different", "from", "those", "of", "C1418552#ent", "<e2>", "and", "that", "C1705543#ent", "<e1>", "could", "not", "cause", "aberrant", "growth", "of", "neurite", "into", "the", "plaque", "."], "h": {"id": "C1418552", "name": "C1418552#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [7, 8]}}
{"token": ["The", "data", "are", "consistent", "with", "role", "of", "MBD3L2", "as", "a", "transcriptional", "modulator", "can", "interchange", "with", "C1417050#ent", "<e1>", "as", "an", "MBD3-interacting", "component", "of", "the", "C0960948#ent", "<e2>", "complex", "."], "h": {"id": "C1417050", "name": "C1417050#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0960948", "name": "C0960948#ent", "pos": [23, 24]}}
{"token": ["Our", "analyses", "reveal", "that", "both", "cyclin", "B1", "cyclin", "B2", "as", "targets", "of", "C1538658#ent", "<e1>", "for", "proper", "Golgi", "and", "C1414461#ent", "<e2>", "assembly", "to", "occur", "."], "h": {"id": "C1538658", "name": "C1538658#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [18, 19]}}
{"token": ["In", "patients", "with", "hypothalamic", "tumors", "empty", "sella", "syndrome", "plasma", "C3273356#ent", "<e1>", "and", "TSH", "levels", "showed", "modest", "or", "no", "increases", "after", "C4283801#ent", "<e2>", "administration", "."], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [20, 21]}}
{"token": ["1", ")", "The", "plasma", "C3273356#ent", "<e1>", "levels", "increased", "significantly", "after", "the", "injection", "of", "C4283801#ent", "<e2>", ",", "TRH", "and", "cimetidine", "."], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "some", "nPRL-Anov", "patients", "have", "elevated", "nocturnal", "serum", "C3273356#ent", "<e1>", "levels", "or", "enhanced", "C3273356#ent", "<e1>", "responsiveness", "to", "C4283801#ent", "<e1>", ",", "indicative", "of", "nocturnal", "or", "latent", "hyperprolactinemia", "."], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [19, 20]}}
{"token": ["C0166429#ent", "<e1>", ",", "acting", "through", "its", "C0025543#ent", "<e2>", "and/or", "disintegrin", "domains", "could", "be", "involved", "in", "sperm", "development", "well", "as", "sperm-egg", "binding", "fusion", "."], "h": {"id": "C0166429", "name": "C0166429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [6, 7]}}
{"token": ["C0148345#ent", "<e1>", ",", "a", "new", "positive", "C0304509#ent", "<e2>", "was", "synthesized", "by", "Tominaga", "et", "al", "of", "the", "Otsuka", "Pharmaceutical", "Co.", "Ltd.", "Institute", "in", "1982", "."], "h": {"id": "C0148345", "name": "C0148345#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304509", "name": "C0304509#ent", "pos": [6, 7]}}
{"token": ["C0148345#ent", "<e1>", "is", "a", "novel", "synthetic", "oral", "C0304509#ent", "<e2>", "has", "been", "successfully", "used", "for", "treatment", "of", "patients", "with", "congestive", "heart", "failure"], "h": {"id": "C0148345", "name": "C0148345#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304509", "name": "C0304509#ent", "pos": [7, 8]}}
{"token": ["Thirteen", "patients", "from", "five", "families", "had", "C3839212#ent", "<e1>", "FH-II", ")", ",", "a", "new", "variety", "of", "C3713420#ent", "<e2>", "suppressible", "with", "dexamethasone", "that", "often", "involves", "adrenocortical", "adenoma", "formation", "."], "h": {"id": "C3839212", "name": "C3839212#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C3713420", "name": "C3713420#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "hypotonic", "infant", "with", "a", "typical", "clinical", "course", "infantile", "acid", "maltase", "deficiency", "whom", "biochemical", "investigation", "revealed", "complete", "C0268487#ent", "<e1>", "of", "both", "C1706105#ent", "<e2>", "debrancher", "enzyme"], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1706105", "name": "C1706105#ent", "pos": [23, 24]}}
{"token": ["Pompe", "disease", "an", "autosomal", "recessive", "disorder", "glycogen", "metabolism", "from", "C0268487#ent", "<e1>", "in", "activity", "of", "the", "C1706105#ent", "<e2>"], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706105", "name": "C1706105#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", "C0048005#ent", "<e1>", "may", "elicit", "the", "secretion", "of", "GH", ",", "prolactin", "and", "C1704793#ent", "<e2>", "via", "the", "central", "nervous", "system"], "h": {"id": "C0048005", "name": "C0048005#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [15, 16]}}
{"token": ["The", "concentration", "and", "time", "course", "C1333909#ent", "<e1>", "+", "released", "into", "the", "medium", "was", "also", "measured", "during", "C0059946#ent", "<e2>", "Ca2", "+", "uptake", "by", "SR", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [16, 17]}}
{"token": ["The", "synergistic", "cytotoxicity", "to", "CHO", "cells", "C0077640#ent", "<e1>", "combinations", "with", "tetraplatin", ",", "5-aza-CR", ",", "or", "C0030899#ent", "<e2>", "was", "not", "due", "to", "increased", "C0077640#ent", "<e1>", "uptake", "or", "increased", "alkylation", "of", "DNA", "by", "C0077640#ent", "<e1>", "."], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0077640", "name": "C0077640#ent", "pos": [6, 7]}}
{"token": ["In", "experiments", "using", "methylxanthines", ",", "C0077640#ent", "<e1>", "combined", "synergistically", "with", "noncytotoxic", "doses", "of", "caffeine", "or", "C0030899#ent", "<e2>", "and", "resulted", "in", "several", "logs", "of", "increase", "in", "C0077640#ent", "<e1>", "cytotoxicity", "."], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0077640", "name": "C0077640#ent", "pos": [5, 6]}}
{"token": ["This", "DB", "fragment", "to", "the", "C1305923#ent", "<e1>", "from", "the", "23rd", "amino", "acid", "residue", "the", "293rd", "amino", "acid", "residue", "C1333207#ent", "<e2>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333207", "name": "C1333207#ent", "pos": [18, 19]}}
{"token": ["The", "DNA", "sequence", "been", "determined", "for", "a", "3.8-kb", "region", "which", "encodes", "the", "mercury-resistance", "(", "mer", ")", "C0022895#ent", "<e1>", "of", "the", "IncFII", "plasmid", "C1538051#ent", "<e2>", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1538051", "name": "C1538051#ent", "pos": [22, 23]}}
{"token": ["Our", "results", "suggest", "a", "genetic", "contribution", "C1969807#ent", "<e1>", "with", "phenotypic", "variability", ",", "including", "C2749929#ent", "<e2>"], "h": {"id": "C1969807", "name": "C1969807#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C2749929", "name": "C2749929#ent", "pos": [13, 14]}}
{"token": ["The", "D(3)-preferring", "agonists", "R-(+)-trans-3,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol", ")", "[", "(+)-PD", "128,907", "]", ",", "(+)-7-hydroxy-dipropylaminotetralin", ",", "and", "the", "mixed", "D(3/)D(2", ")", "C2987634#ent", "<e1>", "quinpirole", "and", "C0139691#ent", "<e2>", "were", "all", "effective", "against", "cocaine", "toxicity", "in", "mice", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0139691", "name": "C0139691#ent", "pos": [21, 22]}}
{"token": ["The", "C0005244#ent", "<e1>", "can", "be", "adsorbed", "in", "C0053858#ent", "<e2>", "specifically", "eluted", "by", "benzylpenicillin", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0053858", "name": "C0053858#ent", "pos": [7, 8]}}
{"token": ["The", "condition", "known", "as", "C0026848#ent", "<e1>", "Progressive", "External", "C0155338#ent", "<e2>", "is", "reviewed", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155338", "name": "C0155338#ent", "pos": [8, 9]}}
{"token": ["C0030946#ent", "<e1>", ",", "lipase", ",", "nonspecific", "C1334064#ent", "<e2>", "and", "direct", "hemolytic", "activities", "were", "found", "primarily", "in", "abdomen", "extracts", "while", "sphingomyelinase", "activity", "predominantly", "in", "the", "toxin", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334064", "name": "C1334064#ent", "pos": [6, 7]}}
{"token": ["This", "was", "concluded", "from", "hyperreactive", "pituitary", "adrenocorticotropic", "hormone", "ACTH", ")", "release", "in", "response", "to", "C1366488#ent", "<e1>", "CRH", ")", "and", "to", "insulin", "induced", "C0020615#ent", "<e2>", "in", "patients", "with", "FM", "."], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [22, 23]}}
{"token": ["The", "81", "C0059256#ent", "<e1>", "[3H]glucosamine", ",", "was", "removed", "from", "virions", "by", "treatment", "with", "C0146951#ent", "<e2>", "bound", "monoclonal", "antibodies", "were", "both", "neutralizing", "and", "protective", "."], "h": {"id": "C0059256", "name": "C0059256#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [13, 14]}}
{"token": ["Little", "attention", "has", "been", "paid", "to", "C0022658#ent", "<e1>", "and", "proteinuria", "in", "C0020545#ent", "<e2>", "RVH", ")", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020545", "name": "C0020545#ent", "pos": [11, 12]}}
{"token": ["Mutations", "in", "ABCA4", ",", "which", "encodes", "a", "photoreceptor", "specific", "ATP-binding", "cassette", "transporter", "C1412063#ent", "<e1>", ")", ",", "cause", "autosomal", "recessive", "forms", "human", "blindness", "due", "to", "retinal", "degeneration", "C1418479#ent", "<e2>", ")", "including", "Stargardt", "disease"], "h": {"id": "C1412063", "name": "C1412063#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418479", "name": "C1418479#ent", "pos": [26, 27]}}
{"token": ["In", "addition", "to", "the", "alpha", "G", "gene", "subjects", "who", "synthesized", "33", "%", "Hb", "G", "two", "C2985256#ent", "<e1>", "the", "homologous", "chromosome", "exhibited", "the", "mild", "form", "of", "C0472762#ent", "<e2>", "\"", "silent", "carrier", ")", "."], "h": {"id": "C2985256", "name": "C2985256#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0472762", "name": "C0472762#ent", "pos": [25, 26]}}
{"token": ["DNA", "sequencing", "a", "previously", "isolated", "C2985256#ent", "<e1>", "a", "3", "'", "untranslated", "region", "identical", "to", "that", "of", "the", "C0472762#ent", "<e2>"], "h": {"id": "C2985256", "name": "C2985256#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0472762", "name": "C0472762#ent", "pos": [17, 18]}}
{"token": ["Mutations", "in", "the", "C1424254#ent", "<e1>", "been", "reported", "in", "six", "C0270853#ent", "<e2>", "JME", ")", "families", "from", "Mexico", "and", "Belize", "."], "h": {"id": "C1424254", "name": "C1424254#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0270853", "name": "C0270853#ent", "pos": [9, 10]}}
{"token": ["Biochemical", "changes", "occurring", "in", "substantia", "nigra", "Parkinson's", "disease", "increased", "iron", "levels", "inhibition", "of", "C0171406#ent", "<e1>", "and", "decreased", "reduced", "glutathione", "levels", ";", "C1260386#ent", "<e2>", ")", "suggest", "that", "oxidative", "stress", "free", "radical", "species", "be", "involved", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [21, 22]}}
{"token": ["Hypodermoclysis", ",", "C0003297#ent", "<e1>", "haloperidol", "and", "scopolamine", ",", "octeotride", ",", "C3540725#ent", "<e2>", ",", "and", "narcotics", "for", "severe", "abdominal", "pain", "alleviate", "symptoms", "."], "h": {"id": "C0003297", "name": "C0003297#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [10, 11]}}
{"token": ["Additional", "topical", "therapies", "C0005088#ent", "<e1>", "clindamycin", ",", "retinoids", ",", "C0038317#ent", "<e2>", "calcineurin", "inhibitors", "and", "permethrin", "are", "not", "approved", "for", "the", "treatment", "of", "rosacea", "and", "play", "variable", "roles", "in", "the", "management", "of", "this", "condition", "."], "h": {"id": "C0005088", "name": "C0005088#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [9, 10]}}
{"token": ["To", "identify", "and", "characterize", "pre-attack", "symptoms", "(", "C3494358#ent", "<e1>", ")", "in", "patients", "with", "familial", "Mediterranean", "fever", "C0031069#ent", "<e2>", ")", "."], "h": {"id": "C3494358", "name": "C3494358#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [16, 17]}}
{"token": ["The", "oxidative", "cleavage", "mechanism", "of", "these", "C3540790#ent", "<e1>", "is", "not", "clear", ",", "and", "both", "monooxygenase", "and", "C0599874#ent", "<e2>", "mechanisms", "have", "been", "proposed", "for", "different", "carotenoid", "cleavage", "C3540790#ent", "<e1>", "."], "h": {"id": "C0599874", "name": "C0599874#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [6, 7]}}
{"token": ["The", "reactivity", "patterns", "and", "geometries", "are", "compared", "with", "oxoiron", "species", "of", "C0599874#ent", "<e1>", "and", "monoxygenase", "C3540790#ent", "<e2>", "."], "h": {"id": "C0599874", "name": "C0599874#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [15, 16]}}
{"token": ["The", "tissue", "inhibitor", "metalloproteases-1", ";", "an", "inhibitor", "of", "C2001899#ent", "<e1>", "does", "not", "inhibit", "cleavage", "by", "the", "C1335528#ent", "<e2>", "shedding", "machinery", ",", "also", "inhibited", "HER2", "ECD", "shedding", ",", "whereas", "tissue", "inhibitor", "metalloproteases-2", "did", "not", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335528", "name": "C1335528#ent", "pos": [16, 17]}}
{"token": ["We", "have", "used", "transgenesis", "to", "replace", "the", "C0597298#ent", "<e1>", "the", "essential", "C1417546#ent", "<e2>", "the", "atrial", "isoform"], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417546", "name": "C1417546#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "our", "evaluation", "and", "surgical", "management", "a", "patient", "presenting", "with", "C0751495#ent", "<e1>", ",", "headaches", ",", "and", "C2827469#ent", "<e2>", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2827469", "name": "C2827469#ent", "pos": [17, 18]}}
{"token": ["A", "single", "nucleotide", "polymorphism", "the", "dog", "C1332826#ent", "<e1>", "these", "animals", "to", "be", "CYP1A2", "deficient", "i.e.", ",", "lack", "functional", "C1620185#ent", "<e2>", "activity", ")", "."], "h": {"id": "C1332826", "name": "C1332826#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [18, 19]}}
{"token": ["During", "the", "differentiation", "of", "the", "intestine", "epithelium", ",", "three", "C1414120#ent", "<e1>", "villin", ",", "fimbrin", ",", "and", "C0086669#ent", "<e2>", "are", "sequentially", "expressed", "and", "localized", "to", "the", "apical", "membrane"], "h": {"id": "C1414120", "name": "C1414120#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086669", "name": "C0086669#ent", "pos": [16, 17]}}
{"token": ["Ocular", "uptake", "of", "glycylsarcosine", "was", "inhibited", "by", "peptide", "transporter", "substrates", "such", "as", "dipeptides", "(", "glycylproline", "and", "C3495555#ent", "<e1>", ")", "and", "captopril", "but", "not", "by", "non-substrates", "such", "as", "C3539947#ent", "<e2>"], "h": {"id": "C3495555", "name": "C3495555#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [27, 28]}}
{"token": ["Thus", ",", "C3495555#ent", "<e1>", "and", "its", "constituent", "C3539947#ent", "<e2>", "have", "therapeutic", "potential", "in", "preventing", "diabetes-induced", "atherosclerosis", "."], "h": {"id": "C3495555", "name": "C3495555#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [7, 8]}}
{"token": ["In", "patients", "with", "prolonged", "or", "complicated", "febrile", "C0751495#ent", "<e1>", "such", "as", "hemiconvulsion-hemiplegia-epilepsy", "syndrome", "C2746066#ent", "<e2>", "be", "included", "in", "the", "differential", "diagnosis", "especially", "in", "children", "with", "concomitant", "macrocephaly", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2746066", "name": "C2746066#ent", "pos": [13, 14]}}
{"token": ["C0275522#ent", "<e1>", "form", "of", "C1420610#ent", "<e2>", "was", "diagnosed", "in", "3.7", "%", "of", "cases", ",", "febrile", "in", "48.3", "%", ",", "meningeal", "in", "36.3", "%", ",", "focal", "in", "11.7", "%", "."], "h": {"id": "C0275522", "name": "C0275522#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [4, 5]}}
{"token": ["Differences", "in", "mean", "power", "frequency", "C0079805#ent", "<e1>", ")", "calculated", "during", "C2699119#ent", "<e2>", "would", "be", "representative", "of", "a", "recruitment", "of", "motor", "units", "MUs", ")", "that", "is", ",", "at", "least", "partly", ",", "task-dependent", "."], "h": {"id": "C0079805", "name": "C0079805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2699119", "name": "C2699119#ent", "pos": [10, 11]}}
{"token": ["In", "rats", "C0342895#ent", "<e1>", "Na5P3O10", "or", "K5P3O10", ",", "urinary", "albumin", "excretion", "and", "N-acetyl-beta-D-glucosaminidase", "(", "C1709111#ent", "<e2>", ")", "activity", "in", "the", "urine", "were", "increased", "in", "rats", "fed", "the", "high", "phosphorus", "diet"], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1709111", "name": "C1709111#ent", "pos": [14, 15]}}
{"token": ["SAPK", ",", "a", "subfamily", "of", "the", "C1979930#ent", "<e1>", "MAP", ")", "kinases", ",", "is", "a", "major", "C0033640#ent", "<e2>", "phosphorylates", "c-Jun", "and", "other", "transcription", "factors"], "h": {"id": "C1979930", "name": "C1979930#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [15, 16]}}
{"token": ["The", "biological", "functional", "genetic", "association", "studies", "that", "the", "Glu298Asp", "polymorphism", "of", "the", "C1328053#ent", "<e1>", "NOS3", ")", "may", "be", "a", "genetic", "risk", "factor", "C0002395#ent", "<e2>", "LOAD", ")", "."], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [22, 23]}}
{"token": ["The", "biological", "functional", "genetic", "association", "studies", "that", "the", "Glu298Asp", "polymorphism", "of", "the", "ecNOS", "gene", "C1328053#ent", "<e1>", ")", "may", "be", "a", "genetic", "risk", "factor", "C0002395#ent", "<e2>", "LOAD", ")", "."], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [23, 24]}}
{"token": ["The", "\"", "C0027341#ent", "<e1>", "(", "NPS", ")", "is", "an", "autosomal", "dominant", "C0019247#ent", "<e2>"], "h": {"id": "C0027341", "name": "C0027341#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [11, 12]}}
{"token": ["The", "nail", "--", "C0027341#ent", "<e1>", "a", "rare", ",", "C0019247#ent", "<e2>", "the", "connective", "tissue", "which", "multiple", "osseous", "abnormalities", "associated", "with", "dysplasia", "of", "the", "nails", "."], "h": {"id": "C0027341", "name": "C0027341#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [8, 9]}}
{"token": ["Coinfection", "with", "C1706586#ent", "<e1>", "activates", "Mek1", ">", "150-fold", ",", "and", "C0275524#ent", "<e2>", "with", "C1706586#ent", "<e1>", "and", "Mek1", "activates", "Erk1", "approximately", "90-fold", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [10, 11]}}
{"token": ["C0721797#ent", "<e1>", "to", "the", "C2364135#ent", "<e2>", "of", "many", "patients", "being", "transported", "by", "ambulance", "."], "h": {"id": "C0721797", "name": "C0721797#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [4, 5]}}
{"token": ["This", "inference", "was", "based", "on", "the", "inhibitory", "action", "of", "antibodies", "specific", "for", "Galphas", ",", "Galphai", ",", "and", "phosphatidylinositol", "4,5-bisphosphate", "C0043167#ent", "<e1>", "RGS4", ",", "a", "fragment", "of", "beta-adrenergic", "receptor", "kinase", "inhibitors", "of", "C0010531#ent", "<e2>"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [31, 32]}}
{"token": ["In", "adult", "patients", "with", "a", "known", "specific", "disease", "such", "as", "celiac", "disease", "chronic", "pseudointestinal", "obstruction", "other", "C0008679#ent", "<e1>", "even", "with", "accompanying", "pneumoperitoneum", ",", "C0032266#ent", "<e2>", "not", "uniformly", "mandate", "surgical", "exploration"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0032266", "name": "C0032266#ent", "pos": [23, 24]}}
{"token": ["CYP11B2", "mRNA", "expression", "and", "CVF", "were", "lower", "in", "a", "C0018802#ent", "<e1>", "subgroup", "treated", "with", "combination", "of", "C0037982#ent", "<e2>", "and", "angiotensin-converting", "enzyme", "inhibitors", "ACEIs", ")", "than", "in", "a", "subgroup", "not", "treated", "with", "drugs", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [16, 17]}}
{"token": ["The", "RALES", "study", "has", "demonstrated", "convincingly", "that", "in", "patients", "with", "C0018802#ent", "<e1>", "addition", "of", "the", "mineralocorticoid", "receptor", "antagonist", "C0037982#ent", "<e2>", "(", "25", "mg/d", ")", "to", "ACE", "inhibition", "markedly", "reduces", "mortality", "and", "prevents", "worsening", "C0018802#ent", "<e1>"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [18, 19]}}
{"token": ["The", "expression", "of", "phosphorylation-dependent", ",", "active", "transcription", "substrates", "of", "these", "C0010536#ent", "<e1>", ",", "including", "cyclic", "AMP-responsive", "element-binding", "protein", "CREB", ")", "C1504731#ent", "<e2>", ",", "ATF-2", ",", "c-Myc", "and", "c-Jun", "was", "examined", "at", "early", "stages", "reperfusion", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1504731", "name": "C1504731#ent", "pos": [20, 21]}}
{"token": ["Comparison", "of", "the", "masses", "of", "C0030956#ent", "<e1>", "of", "partial", "amino", "acid", "sequences", "from", "brain", "and", "retinal", "C1707995#ent", "<e2>", "indicated", "that", "the", "two", "proteins", "are", "probably", "identical", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1707995", "name": "C1707995#ent", "pos": [16, 17]}}
{"token": ["Apart", "from", "generalised", "symptoms", "fever", ",", "C3890602#ent", "<e1>", "and", "headache", ")", ",", "C0037090#ent", "<e2>", "particularly", "cough", ",", "were", "prominent", "."], "h": {"id": "C3890602", "name": "C3890602#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037090", "name": "C0037090#ent", "pos": [12, 13]}}
{"token": ["C0354594#ent", "<e1>", "not", "significantly", "increase", "the", "quantitative", "values", "for", "C0537086#ent", "<e2>", "GST-P", ")", "positive", "liver", "cell", "foci", "after", "DEN", "initiation", ",", "in", "clear", "contrast", "to", "the", "positive", "control"], "h": {"id": "C0354594", "name": "C0354594#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [9, 10]}}
{"token": ["C0354594#ent", "<e1>", "not", "significantly", "increase", "the", "quantitative", "values", "for", "glutathione", "S-transferase", "placental", "form", "C0537086#ent", "<e2>", ")", "positive", "liver", "cell", "foci", "after", "DEN", "initiation", ",", "in", "clear", "contrast", "to", "the", "positive", "control"], "h": {"id": "C0354594", "name": "C0354594#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [13, 14]}}
{"token": ["Following", "additional", "C0041236#ent", "<e1>", "treatment", ",", "infectivity", "was", "enhanced", "for", "both", "C1417870#ent", "<e2>", "and", "TR", "particles", ",", "but", "the", "infectivity", "of", "C1417870#ent", "<e2>", "remained", "2", "logs", "lower", "than", "that", "of", "TR", "particles", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417870", "name": "C1417870#ent", "pos": [11, 12]}}
{"token": ["C1175888#ent", "<e1>", "UCH-L1", ")", "is", "a", "restrictedly", "expressed", "C0014442#ent", "<e2>", "in", "neural", "and", "reproductive", "tissues", "and", "it", "is", "considered", "to", "have", "a", "significant", "role", "in", "reproduction", "."], "h": {"id": "C1175888", "name": "C1175888#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "3TC", "5'-triphosphate", "on", "both", "the", "RNA-dependent", "and", "C0212694#ent", "<e1>", "activities", "of", "human", "immunodeficiency", "virus", "type", "1", "reverse", "transcriptase", "C0012888#ent", "<e2>", "beta", ",", "and", "gamma", "from", "HeLa", "cells", "investigated", "."], "h": {"id": "C0212694", "name": "C0212694#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012888", "name": "C0012888#ent", "pos": [21, 22]}}
{"token": ["New", "quinolones", "obtained", "a", "definite", "position", "in", "the", "treatment", "of", "certain", "sexually", "transmitted", "diseases", "urinary", "tract", "infections", "C0033581#ent", "<e1>", ",", "gastrointestinal", "infections", "nosocomially", "acquired", "C0024116#ent", "<e2>", "resistant", "organisms", ",", "pseudomonas", "infections", "cystic", "fibrosis", "and", "osteomyelitis", "."], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0024116", "name": "C0024116#ent", "pos": [24, 25]}}
{"token": ["The", "micronutient", "C2713546#ent", "<e1>", "which", "are", "of", "greatest", "public", "health", "include", "iron", "deficiency", "vitamin", "A", "deficiency", "C0342199#ent", "<e2>"], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0342199", "name": "C0342199#ent", "pos": [16, 17]}}
{"token": ["Dietary", "micronutrient", "C2713546#ent", "<e1>", ",", "which", "lead", "to", "diseases", "such", "as", "C0342199#ent", "<e2>", "iron-deficiency", "anemia", "and", "vitamin", "A", "deficiency", "are", "serious", "public", "health", "problems", "the", "developing", "world"], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0342199", "name": "C0342199#ent", "pos": [11, 12]}}
{"token": ["C0009325#ent", "<e1>", "cross-linked", "with", "1-ethyl-3-(3-dimethyl", "aminopropyl)", "carbodiimide", "hydrochloride", "EDC", ")", "and", "N-hydroxysuccinimide", "(", "C0796085#ent", "<e2>", ")", "chemistry", ",", "and", "varying", "amounts", "of", "polypropyleneimine", "octaamine", "generation", "2", "(", "G2", ")", "dendimer", "and", "heparin", "were", "synthesized", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0796085", "name": "C0796085#ent", "pos": [13, 14]}}
{"token": ["We", "successfully", "developed", "a", "novel", "method", "for", "immobilizing", "poly(2-methacryloyloxyethyl", "phosphorylcholine", "[", "Poly(MPC", ")", "]", "polymer", "onto", "C0009325#ent", "<e1>", "using", "N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide", "(", "EDC", ")", "and", "N-hydroxysuccinimide", "(", "C0796085#ent", "<e2>", ")", "as", "cross-linkers", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0796085", "name": "C0796085#ent", "pos": [26, 27]}}
{"token": ["The", "dopaminergic", "agonists", "d-amphetamine", ",", "quipazine", ",", "C0006230#ent", "<e1>", ",", "cocaine", "and", "C0054876#ent", "<e2>", "did", "not", "substitute", "for", "lisuride", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0054876", "name": "C0054876#ent", "pos": [12, 13]}}
{"token": ["C1418938#ent", "<e1>", "interferes", "with", "the", "function", "of", "the", "C0010093#ent", "<e2>", "as", "was", "demonstrated", "by", "repeatedly", "finding", "a", "short", "luteal", "phase", "the", "ovulatory", "cycles", "two", "hyperprolactinaemic", "women", "after", "prolactin", "supression", "by", "bromocriptine", "had", "been", "discontinued", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010093", "name": "C0010093#ent", "pos": [8, 9]}}
{"token": ["C1418938#ent", "<e1>", "and", "estradiol", "stimulated", "only", "the", "cells", "of", "C0010093#ent", "<e2>", "early", "luteal", "phase"], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010093", "name": "C0010093#ent", "pos": [9, 10]}}
{"token": ["C0022660#ent", "<e1>", "disseminated", "intravascular", "coagulation", "ARDS", ",", "hypoglycaemia", ",", "coma", "or", "C0014544#ent", "<e2>", "manifestations", "of", "severe", "Plasmodium", "falciparum", "malaria", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [11, 12]}}
{"token": ["Human", "SLC4A1/AE1", "mutations", "cause", "either", "the", "erythroid", "disorders", "C0037889#ent", "<e1>", "ovalocytosis", ",", "or", "C1704380#ent", "<e2>"], "h": {"id": "C0037889", "name": "C0037889#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704380", "name": "C1704380#ent", "pos": [13, 14]}}
{"token": ["C1414919#ent", "<e1>", "binding", "was", "significantly", "decreased", "in", "the", "globus", "pallidus", "C3811116#ent", "<e2>", ")", "in", "symptomatic", "cats", "and", "returned", "to", "normal", "levels", "in", "spontaneously", "recovered", "cats", "."], "h": {"id": "C1414919", "name": "C1414919#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3811116", "name": "C3811116#ent", "pos": [10, 11]}}
{"token": ["alpha(2A)/alpha(2C)ARKO", "mice", "displayed", "exercise", "intolerance", ",", "systolic", "dysfunction", "increased", "cardiac", "myocyte", "width", ",", "and", "ventricular", "fibrosis", "by", "decreased", "C0916183#ent", "<e1>", "and", "increased", "C1415651#ent", "<e2>", "expression", "levels", "."], "h": {"id": "C0916183", "name": "C0916183#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1415651", "name": "C1415651#ent", "pos": [22, 23]}}
{"token": ["The", "success", "of", "antiviral", "therapy", "C0019340#ent", "<e1>", "partly", "turns", "on", "the", "ability", "to", "bring", "the", "C1254351#ent", "<e2>", "into", "close", "contact", "with", "the", "infected", "tissues", "."], "h": {"id": "C0019340", "name": "C0019340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["Endogenously", "generated", "protoporphyrin", "IX", "C1121290#ent", "<e1>", ")", "from", "exogenous", "C0876231#ent", "<e2>", "ALA", ")", "has", "the", "photodynamic", "capacity", "to", "inactive", "cancer", "cells", "different", "origins", "."], "h": {"id": "C1121290", "name": "C1121290#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0876231", "name": "C0876231#ent", "pos": [9, 10]}}
{"token": ["The", "expression", "of", "these", "C0017337#ent", "<e1>", "was", "further", "enhanced", "in", "flies", "lacking", "both", "dICAD", "and", "C0057459#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0057459", "name": "C0057459#ent", "pos": [15, 16]}}
{"token": ["Co-immunoprecipitation", "assays", "the", "interactions", "of", "C3811127#ent", "<e1>", "with", "the", "latter", "three", "C0086376#ent", "<e2>", "."], "h": {"id": "C3811127", "name": "C3811127#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["This", "\"", "light-enhanced", "dark", "respiration", "\"", "(", "C0013615#ent", "<e1>", ")", "was", "a", "function", "of", "both", "the", "C0720099#ent", "<e2>", "of", "illumination", "and", "the", "photon", "fluence", "rate", "."], "h": {"id": "C0013615", "name": "C0013615#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [16, 17]}}
{"token": ["The", "genes", "A1", "A2", "and", "C1706319#ent", "<e1>", "are", "linked", "C1516876#ent", "<e2>", "whereas", "the", "fourth", "gene", "the", "gene", "B2", "segregates", "independently", "."], "h": {"id": "C1706319", "name": "C1706319#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [9, 10]}}
{"token": ["A", "database", "search", "could", "identify", "the", "four", "C0848332#ent", "<e1>", "as", "isoforms", "of", "the", "C0243769#ent", "<e2>", "PGD-S", ")", "."], "h": {"id": "C0848332", "name": "C0848332#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243769", "name": "C0243769#ent", "pos": [13, 14]}}
{"token": ["Sixteen", "patients", "with", "different", "types", "of", "C0020476#ent", "<e1>", "were", "treated", "with", "clofibrate", "analogues", "bezafibrate", "or", "C0033228#ent", "<e2>", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [15, 16]}}
{"token": ["DFO", "suppressed", "the", "expression", "of", "epithelial", "differentiation", "markers", "such", "as", "involucrin", ",", "CK6", ",", "and", "C1705721#ent", "<e1>", ",", "and", "this", "suppression", "was", "blocked", "by", "p38", "and", "C1705791#ent", "<e2>", "MAP", "kinase", "inhibitors"], "h": {"id": "C1705721", "name": "C1705721#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [26, 27]}}
{"token": ["To", "provide", "further", "insights", "into", "the", "role", "of", "C1417836#ent", "<e1>", "in", "the", "final", "differentiation", "pathway", "we", "have", "examined", "the", "C1539479#ent", "<e2>", "of", "dopamine", "cell", "precursors", "in", "C1417836#ent", "<e1>", "null", "mutant", "mice", "."], "h": {"id": "C1417836", "name": "C1417836#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", "an", "attempt", "is", "made", "to", "elucidate", "the", "effects", "of", "various", "cosolvents", ",", "such", "as", "C0037688#ent", "<e1>", ",", "sucrose", ",", "xylose", "and", "glycerol", ",", "on", "C0030346#ent", "<e2>", "."], "h": {"id": "C0037688", "name": "C0037688#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030346", "name": "C0030346#ent", "pos": [28, 29]}}
{"token": ["The", "influence", "of", "different", "polyhydroxylic", "cosolvents", "(", "ethylene", "glycol", "glycerol", ",", "erythritol", ",", "xylitol", "and", "C0037688#ent", "<e1>", ")", "on", "the", "thermostability", "of", "C0030346#ent", "<e2>", "at", "60", "degrees", "C", "was", "also", "studied", "."], "h": {"id": "C0037688", "name": "C0037688#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030346", "name": "C0030346#ent", "pos": [22, 23]}}
{"token": ["Two", "C1305923#ent", "<e1>", "coprecipitated", "with", "C1412100#ent", "<e2>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412100", "name": "C1412100#ent", "pos": [5, 6]}}
{"token": ["Both", "peaks", "1", "and", "2", "dephosphorylated", "C1446659#ent", "<e1>", "phosphorylated", "by", "Ca2+/calmodulin-dependent", "protein", "kinase", "II", "the", "catalytic", "subunit", "C1956039#ent", "<e2>"], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956039", "name": "C1956039#ent", "pos": [17, 18]}}
{"token": ["Evidence", "from", "clinical", "observation", "population", "studies", "that", "C0154723#ent", "<e1>", "sometimes", "transforms", "into", "C0149931#ent", "<e2>"], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [12, 13]}}
{"token": ["The", "role", "of", "iron", "deficiency", "the", "development", "of", "C0006849#ent", "<e1>", "investigated", "using", "the", "mouse", "mutant", "sex-linked", "anaemia", "(", "C1420083#ent", "<e2>", ")", "."], "h": {"id": "C0006849", "name": "C0006849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420083", "name": "C1420083#ent", "pos": [18, 19]}}
{"token": ["Proteins", "that", "are", "involved", "in", "chylomicron", "assembly", "secretion", ",", "including", "MTP", ",", "C1417133#ent", "<e1>", ",", "DGAT", ",", "apoAI-V", ",", "and", "C0018296#ent", "<e2>", "show", "evidence", "of", "increased", "expression", "and", "activity", "levels"], "h": {"id": "C1417133", "name": "C1417133#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [20, 21]}}
{"token": ["C0039832#ent", "<e1>", "treatment", "was", "used", "to", "chemosterilize", "adult", "C0018889#ent", "<e2>", "in", "vivo"], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [8, 9]}}
{"token": ["C0039832#ent", "<e1>", "and", "mebendazole", "treatment", "resulted", "in", "complete", "eradication", "of", "Trichinella", "spiralis", "C0018889#ent", "<e2>", "of", "small", "intestine", "marked", "reduction", "of", "larval", "infection", "(", "mild", "infection", "of", "skeletal", "muscle"], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [12, 13]}}
{"token": ["A", "quantitative", "study", "horizontal", "and", "vertical", "optokinetic", "nystagmus", "C2974636#ent", "<e1>", ")", "and", "optocollic", "reflex", "(", "C1418944#ent", "<e2>", ")", "has", "been", "performed", "in", "the", "pigeon", "using", "the", "search-coil", "technique"], "h": {"id": "C2974636", "name": "C2974636#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418944", "name": "C1418944#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "this", "study", "suggests", "that", "C1705518#ent", "<e1>", ",", "working", "through", "a", "C1417816#ent", "<e2>", "has", "dual", "and", "opposing", "effects", "on", "CRF", "and", "noradrenaline", "overflow", "in", "vitro"], "h": {"id": "C1705518", "name": "C1705518#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417816", "name": "C1417816#ent", "pos": [12, 13]}}
{"token": ["Conversely", ",", "C1705518#ent", "<e1>", "increases", "nitric", "oxide", "production", "and", "this", "potentiation", "is", "mediated", "via", "C1417816#ent", "<e2>"], "h": {"id": "C1705518", "name": "C1705518#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417816", "name": "C1417816#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "of", "acute", "renal", "failure", "C0525037#ent", "<e1>", ")", "on", "the", "disposition", "of", "phenolsulfonphthalein", "(", "C1332754#ent", "<e2>", ")", "after", "intravenous", "administration", "investigated", "in", "rats", "."], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [15, 16]}}
{"token": ["Surprisingly", ",", "C1538714#ent", "<e1>", "activity", "was", "increased", "in", "OA", "C1413269#ent", "<e2>", "under", "the", "same", "conditions", "."], "h": {"id": "C1538714", "name": "C1538714#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413269", "name": "C1413269#ent", "pos": [9, 10]}}
{"token": ["Validation", "of", "clearance", "of", "TSEs", "from", "pooled", "plasma", "products", "demonstrates", "effective", "removal", "of", "the", "C0991617#ent", "<e1>", "in", "downscaled", "systems", "and", "studies", "comparing", "C0376329#ent", "<e2>", ",", "BSE", "and", "scrapie", "C0991617#ent", "<e1>", "yield", "similar", "results", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0376329", "name": "C0376329#ent", "pos": [22, 23]}}
{"token": ["Using", "a", "baculovirus", "system", "we", "demonstrate", "that", "the", "serine/threonine", "kinase", "Fu", "phosphorylates", "C0255632#ent", "<e1>", "C0669372#ent", "<e2>", "when", "coexpressed", "with", "C0669372#ent", "<e2>", "."], "h": {"id": "C0255632", "name": "C0255632#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [14, 15]}}
{"token": ["4", ")", "intra-arterial", "administration", "high-dose", "methotrexate", ",", "C0771987#ent", "<e1>", "and", "intravenous", "administration", "high-dose", "cytosine", "arabinoside", "be", "expected", "to", "be", "a", "useful", "C0003392#ent", "<e2>"], "h": {"id": "C0771987", "name": "C0771987#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [21, 22]}}
{"token": ["Ras", "associates", "with", "TLR2", "and", "activates", "the", "mitogen-activated", "protein", "kinase", "MAPK", ")", "C0082529#ent", "<e1>", "ERK", ")", ",", "whereas", "tumor", "necrosis", "factor", "receptor-associated", "factor", "6", "C0812325#ent", "<e2>", "kinase", "1", "(TAK1)-dependent", "signaling", "activates", "p38", "MAPK"], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [24, 25]}}
{"token": ["C3272781#ent", "<e1>", "microsomal", "CYP4A", "content", "and", "C0051169#ent", "<e2>", "increased", "in", "rat", "hepatocytes", "by", "the", "addition", "of", "100", "microM", "clofibrate", "or", "Wy14,643", "for", "two", "days", "."], "h": {"id": "C3272781", "name": "C3272781#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [6, 7]}}
{"token": ["omega-Hydroxydodecanoic", "acid", "(", "100", "microM", ")", "also", "increased", "C3272781#ent", "<e1>", "but", "had", "no", "clear", "effect", "on", "microsomal", "C0051169#ent", "<e2>", "level", "and", "laurate", "omega-hydroxylation"], "h": {"id": "C3272781", "name": "C3272781#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [17, 18]}}
{"token": ["To", "express", "the", "C1706821#ent", "<e1>", "of", "Trichinella", "spiralis", "purify", "the", "C0034861#ent", "<e2>", "test", "its", "antigenicity", "."], "h": {"id": "C1706821", "name": "C1706821#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [10, 11]}}
{"token": ["C0040615#ent", "<e1>", "possess", "differential", "neurotoxic", "activity", "higher", "sensitivity", "of", "neoplasm", "tissue", "C0919442#ent", "<e2>", "compared", "to", "primary", "cultures", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919442", "name": "C0919442#ent", "pos": [11, 12]}}
{"token": ["Gallium", "nitrate", "an", "antitumor", "agent", "noncytotoxic", "to", "osteoclasts", "and", "bone", "cells", "appears", "to", "be", "more", "effective", "than", "pamidronate", ",", "C0086268#ent", "<e1>", ",", "and", "calcitonin", "in", "the", "treatment", "of", "C0020437#ent", "<e2>"], "h": {"id": "C0086268", "name": "C0086268#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [28, 29]}}
{"token": ["Clinical", "discussion", "confined", "to", "C1419789#ent", "<e1>", "in", "childhood", ",", "the", "hair", ",", "nails", "and", "mucosal", "psoriasis", "C0152081#ent", "<e2>", "C1419789#ent", "<e1>", "arthropathica", "."], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0152081", "name": "C0152081#ent", "pos": [16, 17]}}
{"token": ["It", "is", "suggested", "that", "C0025942#ent", "<e1>", "changes", "the", "lipid", "organization", "binding", "to", "the", "lipids", ",", "whereas", "C0022625#ent", "<e2>", "is", "localized", "in", "the", "multilayer", "without", "having", "an", "important", "direct", "effect", "on", "the", "lipid", "organization"], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [16, 17]}}
{"token": ["Treatment", "with", "topical", "and", "subconjunctival", "C0025942#ent", "<e1>", "along", "with", "C0022625#ent", "<e2>", "resulted", "in", "healing", "in", "13", "cases", "."], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [9, 10]}}
{"token": ["C0106940#ent", "<e1>", "contained", "alpha", "1-proteinase", "inhibitor", "however", ",", "the", "urokinase", "inhibitor", "distinguishable", "from", "such", "C0162758#ent", "<e2>", "immunologically", "."], "h": {"id": "C0106940", "name": "C0106940#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [14, 15]}}
{"token": ["We", "have", "established", "the", "minimal", "sequence", "and", "factor", "requirements", "both", "C0907533#ent", "<e1>", "and", "viral-induced", "transcription", "an", "atypical", ",", "C0003486#ent", "<e2>", "box-containing", "human", "housekeeping", "promoter", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [18, 19]}}
{"token": ["Comparison", "of", "the", "intraocular", "pressureincreasing", "effect", "in", "known", "corticosteroid", "responders", "of", "dexamethasone", "acetate", "that", "of", "C2930043#ent", "<e1>", "the", "least", "effective", "of", "the", "C0011777#ent", "<e2>", ",", "demonstrated", "no", "difference", "between", "the", "two", "drugs", "."], "h": {"id": "C2930043", "name": "C2930043#ent", "pos": [15, 16]}, "relation": "has_constitutional_part", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [22, 23]}}
{"token": ["HPLC", "assays", "for", "the", "determination", "of", "DA", ",", "C2930043#ent", "<e1>", "DSP", ")", "and", "C0011777#ent", "<e2>", "(", "Dex", ")", "were", "developed", ",", "separately", "."], "h": {"id": "C2930043", "name": "C2930043#ent", "pos": [8, 9]}, "relation": "has_constitutional_part", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [13, 14]}}
{"token": ["Immunohistochemistry", "staining", "the", "HL", "cells", "positive", "for", "CD45", ",", "CD20", ",", "Bc16", ",", "EMA", "and", "C1428883#ent", "<e1>", "and", "negative", "for", "CD15", "and", "C1705984#ent", "<e2>", "."], "h": {"id": "C1428883", "name": "C1428883#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705984", "name": "C1705984#ent", "pos": [22, 23]}}
{"token": ["C2698196#ent", "<e1>", "is", "also", "metabolised", "by", "C1142644#ent", "<e2>", ",", "in", "vitro", "atorvastatin", "inhibits", "the", "cytochrome", "P450", "metabolism", "of", "mexazolam", "."], "h": {"id": "C2698196", "name": "C2698196#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}}
{"token": ["Since", "certain", "lipophilic", "statins", "i.e.", "simvastatin", ",", "C2698196#ent", "<e1>", ",", "lovastatin", ")", "are", "a", "substrate", "of", "C1142644#ent", "<e2>", ",", "we", "were", "interested", "in", "potential", "drug", "interactions", "clopidogrel", "and", "statins", "."], "h": {"id": "C2698196", "name": "C2698196#ent", "pos": [7, 8]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [16, 17]}}
{"token": ["In", "the", "present", "study", "we", "asked", "whether", "nuclear", "sequestration", "of", "C1333908#ent", "<e1>", "preventing", "C1333908#ent", "<e1>", "release", "would", "be", "beneficial", "for", "C1739148#ent", "<e1>", "treatment", "."], "h": {"id": "C1333908", "name": "C1333908#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1739148", "name": "C1739148#ent", "pos": [20, 21]}}
{"token": ["Genes", "encoding", "C3540790#ent", "<e1>", "such", "as", "glutamate/aspartate", "transporter", "GLAST", ")", ",", "nitric", "oxide", "synthetase", "C0669372#ent", "<e2>", ")", "and", "prostaglandin", "G/H", "synthetase", "PGHS-2", ")", "are", "identified", "as", "mechanical", "stress-responsive"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [14, 15]}}
{"token": ["Pseudomonas", "aeruginosa", "two", "extracellular", "staphylolytic", "C3541394#ent", "<e1>", "able", "to", "lyse", "C1318973#ent", "<e2>", "they", "are", "added", "to", "liquid", "cultures", "S.", "aureus"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1318973", "name": "C1318973#ent", "pos": [10, 11]}}
{"token": ["We", "show", "that", "SEC1", ",", "SEC2", ",", "and", "C1428970#ent", "<e1>", "also", "bind", "to", "C1423078#ent", "<e2>", "based", "on", "inhibition", "of", "the", "binding", "of", "radiolabeled", "SEB", "."], "h": {"id": "C1428970", "name": "C1428970#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1423078", "name": "C1423078#ent", "pos": [13, 14]}}
{"token": ["The", "current", "study", "determined", "the", "gene", "structure", "C1422636#ent", "<e1>", "and", "TSGP1", ",", "TSGP2", "and", "TSGP4", ",", "C0078147#ent", "<e2>", "identified", "from", "the", "soft", "tick", "Ornithodoros", "savignyi", "Argasidae", ")", "."], "h": {"id": "C1422636", "name": "C1422636#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0078147", "name": "C0078147#ent", "pos": [16, 17]}}
{"token": ["Mutants", "at", "the", "C1415701#ent", "<e1>", "isolated", "after", "treatment", "of", "cells", "of", "the", "human", "lymphoblastoid", "cell", "line", "C1706168#ent", "<e2>", "with", "X", "rays", "examined", "by", "Northern", "blot", "cDNA", "sequence", "analysis"], "h": {"id": "C1415701", "name": "C1415701#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706168", "name": "C1706168#ent", "pos": [16, 17]}}
{"token": ["Two", "patients", "who", "had", "typical", "vertebrobasilar", "transient", "ischemic", "attacks", "(", "TIAs", ")", "that", "were", "refractory", "to", "anticoagulation", "with", "C0005640#ent", "<e1>", "and", "to", "antiplatelet", "therapy", "C0004057#ent", "<e2>", "and/or", "dipyridamole", "are", "described", "."], "h": {"id": "C0005640", "name": "C0005640#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [24, 25]}}
{"token": ["Furosemide", "acted", "abruptly", "as", "loop", "diuretics", ";", "C0076749#ent", "<e1>", "had", "more", "physiological", "time-courses", ",", "as", "shown", "by", "most", "C0596110#ent", "<e2>", "whose", "main", "site", "of", "renal", "action", "at", "the", "cortical", "diluting", "segment", "."], "h": {"id": "C0076749", "name": "C0076749#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [18, 19]}}
{"token": ["In", "a", "prospective", "trial", "patients", "undergoing", "C1414459#ent", "<e1>", "due", "to", "gastric", "adenoma", "adenocarcinoma", "were", "randomly", "assigned", "to", "C0795650#ent", "<e2>", "or", "famotidine", "."], "h": {"id": "C1414459", "name": "C1414459#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0795650", "name": "C0795650#ent", "pos": [17, 18]}}
{"token": ["Among", "CYP3A", "subfamily", ",", "C1413882#ent", "<e1>", "is", "polymorphically", "expressed", "and", "the", "CYP3A5*3", "CYP3A5*6", "C0002085#ent", "<e2>", "are", "known", "not", "to", "express", "functional", "C1413882#ent", "<e1>", "."], "h": {"id": "C1413882", "name": "C1413882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "cytologic", "changes", "in", "horses", "with", "recurrent", "airway", "obstruction", "(", "C3714496#ent", "<e1>", ")", "after", "administration", "of", "aerosolized", "C0004906#ent", "<e2>", "dexamethasone", "parenterally", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004906", "name": "C0004906#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "changes", "in", "clinical", "signs", "disease", "and", "response", "to", "pulmonary", "function", "testing", "horses", "with", "recurrent", "airway", "obstruction", "(", "C3714496#ent", "<e1>", ")", "after", "aerosol", "and", "parenteral", "administration", "C0004906#ent", "<e2>", "dexamethasone", ",", "respectively", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0004906", "name": "C0004906#ent", "pos": [27, 28]}}
{"token": ["To", "determine", "alteration", "in", "adrenocortical", "function", "horses", "with", "recurrent", "airway", "obstruction", "(", "C3714496#ent", "<e1>", ")", "after", "aerosol", "and", "parenteral", "administration", "C0004906#ent", "<e2>", "dexamethasone", ",", "respectively", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004906", "name": "C0004906#ent", "pos": [20, 21]}}
{"token": ["Hemin", "administration", "into", "the", "air", "pouch", "caused", "an", "elevation", "of", "C1415619#ent", "<e1>", "bilirubin", "levels", "induced", "by", "zymosan", "with", "inhibition", "of", "C1705323#ent", "<e2>", "expression", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [20, 21]}}
{"token": ["This", "study", "evaluated", "the", "effects", "of", "C0055729#ent", "<e1>", "on", "walking", "distances", "patients", "with", "C0021775#ent", "<e2>", "IC", ")", "caused", "by", "peripheral", "arterial", "occlusive", "disease"], "h": {"id": "C0055729", "name": "C0055729#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0021775", "name": "C0021775#ent", "pos": [13, 14]}}
{"token": ["The", "endothelins", "consist", "of", "a", "family", "of", "C4255305#ent", "<e1>", "peptides", "originally", "isolated", "from", "C0669365#ent", "<e2>", "are", "now", "known", "to", "be", "involved", "in", "neuroendocrine", "regulation"], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [13, 14]}}
{"token": ["In", "search", "of", "evidence", "which", "suggests", "the", "possible", "activation", "of", "the", "human", "C1442788#ent", "<e1>", "we", "have", "screened", "C0011522#ent", "<e2>", "and", "RNAs", "from", "a", "number", "of", "human", "tumor", "cell", "lines"], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [17, 18]}}
{"token": ["C1417672#ent", "<e1>", "is", "required", "for", "MAD2", "but", "not", "MAD1", ",", "C3710678#ent", "<e2>", ",", "and", "HEC1", "to", "associate", "with", "kinetochores", "."], "h": {"id": "C1417672", "name": "C1417672#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3710678", "name": "C3710678#ent", "pos": [10, 11]}}
{"token": ["Nevertheless", ",", "because", "of", "the", "evidence", "on", "the", "importance", "of", "NMDA", "receptor-mediated", "pLasticity", "in", "chronic", "pain", "low", "doses", "C0700541#ent", "<e1>", "have", "been", "explored", "in", "a", "wide", "range", "of", "C0006111#ent", "<e2>"], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0006111", "name": "C0006111#ent", "pos": [28, 29]}}
{"token": ["Sodium", "dodecyl", "sulfate-gel", "electrophoresis", "cation", "exchange", "chromatography", "used", "to", "examine", "degradation", "of", "treated", "and", "untreated", "C0677666#ent", "<e1>", "by", "Bacteroides", "amylophilus", "H18(1", ")", ",", "Bacteroides", "ruminicola", "B(1)4", "pepsin", ",", "C0041236#ent", "<e2>", ",", "and", "intraruminally", "."], "h": {"id": "C0677666", "name": "C0677666#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [28, 29]}}
{"token": ["Pigs", "fed", "a", "C0677666#ent", "<e1>", "to", "have", "greater", "C0041236#ent", "<e2>", "and", "chymotrypsin", "activities", "in", "the", "intestinal", "contents", "and", "lower", "activities", "the", "pancreas", "than", "did", "pigs", "fed", "milk-based", "diets", "."], "h": {"id": "C0677666", "name": "C0677666#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [8, 9]}}
{"token": ["An", "Australian", "patient", "with", "autism", "was", "found", "to", "be", "heterozygous", "for", "two", "mutations", "in", "the", "gene", "encoding", "C1412262#ent", "<e1>", "ASL", ")", ",", "resulting", "in", "the", "C0298973#ent", "<e2>", "and", "D87E", "."], "h": {"id": "C1412262", "name": "C1412262#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0298973", "name": "C0298973#ent", "pos": [25, 26]}}
{"token": ["Thirteen", "weeks", "later", ",", "C0526502#ent", "<e1>", ",", "C0081408#ent", "<e2>", "(", "only", "the", "high", "concentration", ",", "and", "combinations", "of", "C0081408#ent", "<e2>", "with", "either", "C0526502#ent", "<e1>", "or", "MK-886", "reduced", "lung", "tumor", "multiplicity", "."], "h": {"id": "C0081408", "name": "C0081408#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0526502", "name": "C0526502#ent", "pos": [4, 5]}}
{"token": ["The", "following", "illustrates", "this", "problem", "arising", "in", "the", "U.K.", "in", "a", "patient", "in", "whom", "tests", "for", "amoebiasis", ",", "C1527287#ent", "<e1>", ",", "schistosomiasis", "and", "C0015655#ent", "<e2>", "were", "all", "positive", "."], "h": {"id": "C1527287", "name": "C1527287#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0015655", "name": "C0015655#ent", "pos": [23, 24]}}
{"token": ["At", "concentrations", "from", "2.5", "to", "7.5", "micromol/L", ",", "the", "PPARgamma", "agonists", "induce", "caveolin-1", "and", "phosphorylation", "of", "C0164786#ent", "<e1>", "and", "cotreatment", "with", "the", "PPARgamma", "antagonist", "C1137010#ent", "<e2>", "inhibited", "the", "induction", "response"], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1137010", "name": "C1137010#ent", "pos": [24, 25]}}
{"token": ["The", "discovery", "of", "the", "effectiveness", "of", "oral", "C0003295#ent", "<e1>", "such", "as", "N-acetylcysteine", "(", "C0001047#ent", "<e2>", ")", "for", "acetaminophen", "poisonings", "raised", "questions", "about", "the", "appropriateness", "of", "concomitant", "administration", "with", "activated", "charcoal", "."], "h": {"id": "C0003295", "name": "C0003295#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [13, 14]}}
{"token": ["Two", "analogous", "series", "of", "AMAA", "and", "C1704949#ent", "<e1>", "derivatives", "have", "now", "been", "synthesized", "and", "characterized", "in", "receptor", "binding", "studies", "C0597058#ent", "<e2>"], "h": {"id": "C1704949", "name": "C1704949#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0597058", "name": "C0597058#ent", "pos": [19, 20]}}
{"token": ["Patients", "receiving", "co-trimoxazole", "also", "had", "fewer", "acute", "clinical", "episodes", "of", "C0042029#ent", "<e1>", "patients", "receiving", "C0066105#ent", "<e2>"], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [10, 11]}, "relation": "may_be_prevented_by", "t": {"id": "C0066105", "name": "C0066105#ent", "pos": [14, 15]}}
{"token": ["As", "defects", "in", "each", "of", "three", "steroidogenic", "enzymes", ",", "21-hydroxylase", ",", "11", "C0038296#ent", "<e1>", ",", "and", "3", "beta-hydroxysteroid", "dehydrogenase", "promote", "C0001622#ent", "<e2>", "of", "adrenal", "androgens", "affected", "female", "fetuses", "may", "be", "virilised", "."], "h": {"id": "C0038296", "name": "C0038296#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [20, 21]}}
{"token": ["Restriction", "fragment", "length", "polymorphisms", "RFLPs", ")", "of", "genomic", "C0011522#ent", "<e1>", "from", "49", "clinical", "isolates", "of", "C0302361#ent", "<e2>", "analyzed", "by", "using", "a", "modified", "restriction", "endonuclease", "analysis", "procedure", "to", "investigate", "the", "genetic", "variability", "this", "species", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0302361", "name": "C0302361#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "physiological", "functions", "C1417861#ent", "<e1>", ",", "we", "inactivated", "its", "C0079429#ent", "<e2>", "by", "targeted", "mutagenesis", "in", "embryonic", "stem", "cells"], "h": {"id": "C1417861", "name": "C1417861#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["Surprisingly", "little", "effect", "was", "seen", "in", "response", "to", "general", "anesthetic", "agents", "thiopental", "and", "C0002348#ent", "<e1>", ")", "and", "other", "C0007681#ent", "<e2>", "chlorpromazine", ",", "ethanol", ",", "lidocaine", ",", "paraldehyde", ",", "valproic", "acid", "and", "baclofen", ")", "."], "h": {"id": "C0002348", "name": "C0002348#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0007681", "name": "C0007681#ent", "pos": [18, 19]}}
{"token": ["The", "most", "likely", "explanation", ",", "however", ",", "is", "the", "fact", "that", "fluoxetine", "inhibits", "C0057223#ent", "<e1>", "whereas", "theophylline", "is", "predominately", "C0025517#ent", "<e2>", "by", "cytochrome", "P450", "1A2"], "h": {"id": "C0057223", "name": "C0057223#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [19, 20]}}
{"token": ["Endothelial", "cells", "release", "C1336938#ent", "<e1>", "vWf", ")", "either", "C0907533#ent", "<e2>", "or", "by", "a", "regulated", "pathway", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}}
{"token": ["C1336938#ent", "<e1>", "vWF", ")", "is", "a", "C0907533#ent", "<e2>", "and", "specific", "component", "of", "endothelial", "cell", "EC", ")", "matrix", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}}
{"token": ["On", "the", "contrary", ",", "predominantly", "antidopaminergic", "drugs", "pimozide", "and", "in", "lesser", "extent", "C0242518#ent", "<e1>", ")", "elevated", "the", "circulating", "LH", "levels", ",", "and", "reduced", "C0032002#ent", "<e2>", "content", "."], "h": {"id": "C0242518", "name": "C0242518#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [23, 24]}}
{"token": ["Levels", "of", "glutathione", "(", "C1260386#ent", "<e1>", ")", ",", "and", "the", "transcript", "levels", "of", "other", "C3540790#ent", "<e2>", "involved", "in", "C1260386#ent", "<e1>", "homeostasis", "were", "determined", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [14, 15]}}
{"token": ["The", "initial", "fall", "in", "blood", "pressure", "not", "abolished", "by", "pretreatment", "with", "C0042523#ent", "<e1>", ",", "captopril", ",", "indomethacin", ",", "C0022616#ent", "<e2>", ",", "atropine", ",", "methylene", "blue", "ethanol", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [18, 19]}}
{"token": ["C0014060#ent", "<e1>", "is", "the", "main", "aetiology", "for", "C2826078#ent", "<e2>", "(", "over", "50", "p.", "100", ")", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2826078", "name": "C2826078#ent", "pos": [7, 8]}}
{"token": ["The", "(2;5)(p23;q35", ")", "lymphoma-associated", "chromosomal", "translocation", "creates", "a", "novel", "fusion", "gene", "incorporates", "parts", "of", "the", "C1332080#ent", "<e1>", "ALK", ")", "receptor", "tyrosine", "kinase", "and", "C0069141#ent", "<e2>"], "h": {"id": "C1332080", "name": "C1332080#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0069141", "name": "C0069141#ent", "pos": [23, 24]}}
{"token": ["The", "breakpoints", "of", "the", "t(2;5)(p23;q35", ")", "have", "recently", "been", "cloned", "and", "are", "reported", "to", "involve", "a", "novel", "tyrosine", "kinase", "gene", "C1332080#ent", "<e1>", "alk", ")", ",", "on", "chromosome", "2", "the", "C0069141#ent", "<e2>", "npm", ")", "on", "chromosome", "5"], "h": {"id": "C1332080", "name": "C1332080#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0069141", "name": "C0069141#ent", "pos": [29, 30]}}
{"token": ["In", "the", "test", "tube", "several", "proline-directed", "kinases", "particularly", "C1979930#ent", "<e1>", "MAP", ")", "and", "C0081947#ent", "<e2>", "phosphorylate", "tau", "on", "sites", "that", "appear", "to", "mimic", "the", "abnormally", "phosphorylated", "sites", "in", "AD", "."], "h": {"id": "C1979930", "name": "C1979930#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0081947", "name": "C0081947#ent", "pos": [13, 14]}}
{"token": ["In", "the", "OA-treated", "slices", ",", "we", "observed", "a", "dramatic", "increase", "in", "the", "phosphorylation/activation", "of", "ERK1/2", ",", "MEK1/2", ",", "and", "C1138418#ent", "<e1>", "immunohistochemically", "and", "by", "Western", "blots", "phosphorylation-dependent", "antibodies", "against", "these", "C0031727#ent", "<e2>", "."], "h": {"id": "C1138418", "name": "C1138418#ent", "pos": [19, 20]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [30, 31]}}
{"token": ["This", "study", "represents", "the", "first", "report", "of", "the", "involvement", "of", "an", "RNA", "helicase", "the", "p53", "response", "and", "highlights", "a", "novel", "mechanism", "by", "which", "C3541312#ent", "<e1>", "may", "act", "as", "a", "tumour", "cosuppressor", "governing", "C1705526#ent", "<e2>", "transcriptional", "activity"], "h": {"id": "C3541312", "name": "C3541312#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [32, 33]}}
{"token": ["Treatment", "of", "co-transfected", "cells", "with", "phosphatidylinositol-specific", "phospholipase", "C", "the", "complex", "of", "MT4-MMP", "and", "C3541312#ent", "<e1>", "ADAMTS4", "from", "the", "cell", "membrane", "but", "the", "C1705526#ent", "<e2>", "ADAMTS4", "remained", "associated", "."], "h": {"id": "C3541312", "name": "C3541312#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [22, 23]}}
{"token": ["By", "using", "this", "method", ",", "plasmin", "and", "trypsin", "(", "C0036734#ent", "<e1>", "were", "detected", ",", "but", "papain", "(", "C0010661#ent", "<e2>", "or", "pepsin", "(", "acidic", "protease", "was", "not", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010661", "name": "C0010661#ent", "pos": [17, 18]}}
{"token": ["It", "is", "suggested", "that", "C0013264#ent", "<e1>", "occur", "in", "adult", "C0175709#ent", "<e2>", "cases", "with", "a", "long", "clinical", "course", "that", "CT", "and", "ultrasound", "scans", "very", "useful", "for", "the", "evaluation", "of", "diseased", "muscles", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0175709", "name": "C0175709#ent", "pos": [9, 10]}}
{"token": ["Sequences", "C1334043#ent", "<e1>", "to", "the", "canonical", "MHC", "class", "II", "C1415492#ent", "<e2>", ")", "gene", "X", "box", "regulatory", "elements", "identified", "within", "the", "HLA-DR", "subregion", "of", "the", "human", "MHC", "and", "termed", "X", "box-like", "(", "XL", ")", "sequences", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415492", "name": "C1415492#ent", "pos": [9, 10]}}
{"token": ["HNF-1alpha", "is", "a", "transcription", "factor", "helps", "in", "the", "tissue-specific", "regulation", "the", "expression", "of", "several", "C0023899#ent", "<e1>", "also", "functions", "as", "a", "weak", "transactivator", "of", "the", "rat", "C1337112#ent", "<e2>"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337112", "name": "C1337112#ent", "pos": [25, 26]}}
{"token": ["Amiodarone", "has", "the", "greatest", "efficacy", "and", "safety", "for", "converting", "C0004238#ent", "<e1>", "and", "maintaining", "NSR", "while", "digoxin", "and", "C0042523#ent", "<e2>", "are", "ineffective", "in", "restoring", "NSR", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [17, 18]}}
{"token": ["Subsequent", "cDNA", "cloning", "C1708432#ent", "<e1>", "to", "be", "a", "fusion", "protein", "two", "C1417679#ent", "<e2>", ",", "the", "novel", "tyrosine", "kinase", "gene", "the", "nucleophosmin", "gene", "in", "accordance", "with", "the", "sequence", "of", "the", "NPM/ALK", "gene", "Morris", "et", "al.", ")", "."], "h": {"id": "C1708432", "name": "C1708432#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["Important", "features", "of", "the", "procedure", "are", "the", "use", "of", "acidic", "buffers", "help", "protect", "the", "C0002523#ent", "<e1>", "acid-tRNA", "linkage", "and", "the", "inclusion", "of", "C0037556#ent", "<e2>", "to", "inhibit", "ribonuclease", "activity"], "h": {"id": "C0002523", "name": "C0002523#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0037556", "name": "C0037556#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "we", "have", "more", "fully", "characterized", "an", "ill-defined", "sequence", "previously", "misidentified", "by", "others", "as", "SAA4", ",", "which", "also", "maps", "to", "C1327812#ent", "<e1>", "may", "represent", "a", "fifth", "C1419798#ent", "<e2>", "locus", "."], "h": {"id": "C1327812", "name": "C1327812#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1419798", "name": "C1419798#ent", "pos": [28, 29]}}
{"token": ["Case", "2", "a", "44-year-old", "woman", ",", "having", "recurring", "breast", "cancer", "was", "treated", "with", "doxorubicin", ",", "and", "C0246415#ent", "<e1>", "developed", "a", "maculo-papular", "rash", "C4284033#ent", "<e2>", ")", "the", "day", "after", "the", "first", "chemotherapy", "treatment", "."], "h": {"id": "C0246415", "name": "C0246415#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4284033", "name": "C4284033#ent", "pos": [22, 23]}}
{"token": ["They", "are", "structurally", "related", "to", "C0033429#ent", "<e1>", "which", "is", "a", "widely", "used", "class", "1", "C0003195#ent", "<e2>", "relatively", "low", "bioavailability", "."], "h": {"id": "C0033429", "name": "C0033429#ent", "pos": [5, 6]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [14, 15]}}
{"token": ["Overall", "C0033429#ent", "<e1>", "has", "been", "shown", "to", "be", "an", "effective", "C0003195#ent", "<e2>", "an", "acceptable", "side", "effect", "for", "the", "acute", "and", "long-term", "treatment", "of", "supraventricular", "arrhythmias"], "h": {"id": "C0033429", "name": "C0033429#ent", "pos": [1, 2]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [10, 11]}}
{"token": ["C0041964#ent", "<e1>", "administered", "in", "drinking", "water", "induced", "C0032285#ent", "<e2>", "alveolar", "and", "bronchiolar", "hyperplasia", "alveolar/bronchiolar", "adenomas", ",", "nephropathy", ",", "cardiomyopathy", ",", "lymphoid", "and", "bone", "marrow", "cell", ",", "seminiferous", "tubule", "degeneration", ",", "and", "ovarian", "atrophy", "follicular", "degeneration", "mice", "."], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [7, 8]}}
{"token": ["It", "was", "also", "related", "to", "the", "concentration", "of", "surface", "receptors", "macrophages", "which", "recognize", "the", "C1335588#ent", "<e1>", "sequence", "within", "fibronectin", "(", "i.e.", "C1416488#ent", "<e2>", ")", "during", "aging", "."], "h": {"id": "C1335588", "name": "C1335588#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1416488", "name": "C1416488#ent", "pos": [21, 22]}}
{"token": ["Differential", "reactivity", "of", "acinar", "and", "ductal", "cells", "the", "developing", "C0030895#ent", "<e1>", "with", "either", "MAb", "50B8", "or", "C1333333#ent", "<e2>", "suggests", "the", "existence", "of", "intermediate", "progenitor", "cells", "in", "their", "differentiation", "potential", "."], "h": {"id": "C0030895", "name": "C0030895#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333333", "name": "C1333333#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "the", "high", "intrafamilial", "variability", "in", "age", "at", "onset", "raises", "the", "question", "of", "whether", "nonallelic", "modifying", "C1417679#ent", "<e1>", "could", "be", "involved", "in", "C1848736#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1848736", "name": "C1848736#ent", "pos": [24, 25]}}
{"token": ["They", "also", "occur", "near", "other", "C0019348#ent", "<e1>", "mutations", "which", "affect", "the", "interactions", "between", "the", "C1335439#ent", "<e2>", "and", "deoxyribonucleoside", "triphosphate", "substrates", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [14, 15]}}
{"token": ["Virus", "selectivity", "based", "on", "virus", "induced", "thymidine", "kinase", "activity", "on", "C0019348#ent", "<e1>", "induction", "of", "C1335439#ent", "<e2>", "the", "incorporation", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [14, 15]}}
{"token": ["The", "variable", "number", "of", "tandem", "repeats", "VNTR", ")", "of", "C0769218#ent", "<e1>", "(", "DXS52", ")", "on", "the", "human", "C0678928#ent", "<e2>", "was", "analysed", "using", "the", "polymerase", "chain", "reaction", "PCR", ")", "method", "."], "h": {"id": "C0769218", "name": "C0769218#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "the", "safety", "and", "efficacy", "of", "a", "single", "intraoperative", "intravitreal", "injection", "of", "C0040866#ent", "<e1>", "phacoemulsification", "in", "patients", "with", "chronic", "idiopathic", "anterior", "uveitis", "C0042164#ent", "<e2>"], "h": {"id": "C0040866", "name": "C0040866#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [23, 24]}}
{"token": ["Furthermore", ",", "overexpression", "of", "C3890397#ent", "<e1>", ",", "which", "encodes", "a", "C0010536#ent", "<e2>", "related", "to", "vertebrate", "MAP", "kinases", "suppressed", "the", "defect", "of", "the", "mkk1", "mkk2", "double", "mutant", "."], "h": {"id": "C3890397", "name": "C3890397#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [10, 11]}}
{"token": ["C1419617#ent", "<e1>", "nuclear", "accumulation", "is", "sufficient", "for", "C0907533#ent", "<e2>", "activation", "of", "its", "specific", "antioxidant", "response"], "h": {"id": "C1419617", "name": "C1419617#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}}
{"token": ["Meperidine", "was", "hydrolyzed", "to", "C0025376#ent", "<e1>", "ethanol", "by", "C1258847#ent", "<e2>", "but", "not", "hCE-2", "."], "h": {"id": "C0025376", "name": "C0025376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [8, 9]}}
{"token": ["C0025376#ent", "<e1>", "was", "hydrolyzed", "to", "meperidinic", "acid", "ethanol", "by", "hCE-1", "but", "not", "C1258847#ent", "<e2>", "."], "h": {"id": "C0025376", "name": "C0025376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [12, 13]}}
{"token": ["C0025376#ent", "<e1>", "was", "hydrolyzed", "to", "meperidinic", "acid", "ethanol", "by", "C1258847#ent", "<e2>", "but", "not", "hCE-2", "."], "h": {"id": "C0025376", "name": "C0025376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [9, 10]}}
{"token": ["The", "C0061532#ent", "<e1>", "fraction", "comprises", "aggregated", "C0086376#ent", "<e2>", "linked", "by", "interchain", "disulphide", "bonds", ";", "they", "have", "a", "varying", "size", "ranging", "from", "about", "500,000", "to", "more", "than", "10", "million", "."], "h": {"id": "C0061532", "name": "C0061532#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}}
{"token": ["One", "BBS", "gene", "MKKS", ")", "has", "been", "identified", "and", "the", "form", "of", "the", "disorder", "caused", "by", "this", "C0079429#ent", "<e1>", "is", "allelic", "to", "C0948368#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0948368", "name": "C0948368#ent", "pos": [22, 23]}}
{"token": ["The", "current", "study", "investigated", "the", "ability", "of", "a", "nitric", "oxide", "derivative", "of", "the", "nonsteroidal", "anti-inflammatory", "drug", "NSAID", ")", "C0016377#ent", "<e1>", ",", "HCT1026", ",", "to", "reduce", "C0014038#ent", "<e2>", "young", "rats", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [25, 26]}}
{"token": ["The", "subsequent", "removal", "of", "C0376261#ent", "<e1>", ",", "but", "not", "glucose", "or", "C0040374#ent", "<e2>", ",", "from", "the", "perifusate", "produced", "a", "dramatic", "potentiation", "of", "insulin", "release", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [11, 12]}}
{"token": ["The", "authors", "review", "the", "results", "of", "the", "clinical", "use", "of", "C0024027#ent", "<e1>", "in", "150", "patients", "with", "associated", "C1956346#ent", "<e2>", "coronary", "atherosclerosis", "according", "to", "coronarography", ")", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [17, 18]}}
{"token": ["C0376515#ent", "<e1>", "overexpression", "in", "Jurkat", "cells", "suppressed", "the", "apoptosis", ",", "but", "C0758917#ent", "<e2>", "processing", "was", "partially", "induced", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0758917", "name": "C0758917#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "CeFACE-1", "and", "C0769557#ent", "<e1>", "are", "bona", "fide", "C1422161#ent", "<e2>", "support", "the", "evolutionary", "conservation", "of", "this", "proteolytic", "system", "eukaryotes", "."], "h": {"id": "C0769557", "name": "C0769557#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1422161", "name": "C1422161#ent", "pos": [11, 12]}}
{"token": ["To", "detect", "pathognomic", "antigen", "expression", ",", "antibodies", "against", "C1880904#ent", "<e1>", "NSE", ")", "as", "a", "marker", "for", "endocrine", "activity", "C1416713#ent", "<e2>", "to", "prove", "the", "epithelial", "character", "of", "cells", "were", "used", "(", "Abb", "."], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416713", "name": "C1416713#ent", "pos": [18, 19]}}
{"token": ["A", "carbohydrate-dependent", "interaction", "between", "newly", "synthesized", "C0072522#ent", "<e1>", ",", "the", "thiol-dependent", "reductase", "ERp57", ",", "and", "either", "C1413107#ent", "<e2>", "or", "calreticulin", "was", "identified", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413107", "name": "C1413107#ent", "pos": [16, 17]}}
{"token": ["The", "induction", "of", "the", "C3540790#ent", "<e1>", "was", "completely", "inhibited", "in", "the", "presence", "of", "C0017718#ent", "<e2>", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017718", "name": "C0017718#ent", "pos": [13, 14]}}
{"token": ["The", "probes", "were", "not", "able", "to", "distinguish", "buffalo-derived", "T.", "parva", ",", "the", "causal", "agent", "C0010105#ent", "<e1>", "from", "cattle-derived", "T.", "parva", ",", "the", "causal", "agent", "C0013467#ent", "<e2>"], "h": {"id": "C0010105", "name": "C0010105#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013467", "name": "C0013467#ent", "pos": [24, 25]}}
{"token": ["A", "patient", "is", "described", "with", "definite", "rheumatoid", "arthritis", "RA", ")", "who", "developed", "life", "threatening", "C0740766#ent", "<e1>", "receiving", "a", "total", "dose", "only", "12.5", "mg", "methotrexate", "(", "C0025677#ent", "<e2>", ")", "."], "h": {"id": "C0740766", "name": "C0740766#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [25, 26]}}
{"token": ["C0740766#ent", "<e1>", "diagnosed", ",", "and", "C0025677#ent", "<e2>", "was", "stopped", "."], "h": {"id": "C0740766", "name": "C0740766#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [5, 6]}}
{"token": ["Although", "Gram-negative", "enteropathogenic", "bacteria", "the", "target", "strains", "of", "C0068746#ent", "<e1>", "and", "nifuroxazide", "treatments", ",", "neither", "C1254351#ent", "<e2>", "affected", "faecal", "counts", "of", "in", "vitro-susceptible", "Enterobacteriaceae", "in", "healthy", "volunteers"], "h": {"id": "C0068746", "name": "C0068746#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["The", "C1539479#ent", "<e1>", "of", "parental", "C0035112#ent", "<e2>", "in", "the", "viral", "replicative", "cycle", "been", "analyzed", "using", "CsCl", "density", "centrifugation"], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035112", "name": "C0035112#ent", "pos": [5, 6]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "the", "ability", "of", "the", "C0028189#ent", "<e1>", "2,3-diphosphoglycerate", "(", "DPG", ")", "to", "inhibit", "phospholipase", "D", "C0388638#ent", "<e2>", ")", "activation", "in", "the", "rabbit", "peritoneal", "neutrophil"], "h": {"id": "C0028189", "name": "C0028189#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0388638", "name": "C0388638#ent", "pos": [21, 22]}}
{"token": ["Diagnostic", "features", "the", "affected", "patients", "included", "C0043144#ent", "<e1>", "refractory", "to", "bronchodilator", "therapy", "persistent", "pulmonary", "infiltrates", "C0014457#ent", "<e2>", "positive", "skin", "reactivity", "an", "A", "fumigatus", "antigen", "elevated", "total", "serum", "IgE", "levels", "."], "h": {"id": "C0043144", "name": "C0043144#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [15, 16]}}
{"token": ["A", "history", "of", "C0043144#ent", "<e1>", "and", "slight", "C0014457#ent", "<e2>", "was", "also", "present", ",", "and", "we", "therefore", "suspected", "allergic", "granulomatous", "angitis"], "h": {"id": "C0043144", "name": "C0043144#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [7, 8]}}
{"token": ["C0001622#ent", "<e1>", "of", "the", "carboxy-terminus", "of", "C1427798#ent", "<e2>", "induces", "oscillatory", "nuclear", "movement", "led", "by", "the", "spindle", "pole", "body", "SPB", ")", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427798", "name": "C1427798#ent", "pos": [6, 7]}}
{"token": ["Seventy-six", "percent", "of", "patients", "identified", "by", "physicians", "as", "C0019099#ent", "<e1>", "patients", "who", "were", "taking", "digoxin", "and", "C0016860#ent", "<e2>", "were", "treated", "with", "ACE", "inhibitor", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [16, 17]}}
{"token": ["We", "demonstrate", "that", "the", "presence", "of", "the", "activated", "C0034677#ent", "<e1>", "decreases", "the", "activity", "of", "this", "specific", "C1539863#ent", "<e2>", "fourfold", "."], "h": {"id": "C0034677", "name": "C0034677#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539863", "name": "C1539863#ent", "pos": [16, 17]}}
{"token": ["Neither", "C1366535#ent", "<e1>", "nor", "OT", "relaxed", "C0917834#ent", "<e2>", "pre-contracted", "aorta", "or", "SMA", "in", "the", "presence", "of", "SR", "49059", ",", "suggesting", "no", "interference", "of", "a", "vasodilatory", "component", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0917834", "name": "C0917834#ent", "pos": [6, 7]}}
{"token": ["C0040034#ent", "<e1>", "persisted", "despite", "aggressive", "immunosuppressive", "therapy", "C0032950#ent", "<e2>", ",", "azathioprine", "and", "vincristine", ")", "but", "resolved", "after", "oral", "C0032950#ent", "<e2>", "was", "replaced", "with", "dexamethasone", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [7, 8]}}
{"token": ["We", "report", "a", "case", "of", "pulmonary", "B-cell", "lymphoma", "a", "patient", "infected", "with", "C3854222#ent", "<e1>", "presented", "with", "a", "left", "empyema", "thoracis", "an", "associated", "left", "lower", "lobe", "abscess", "secondary", "to", "C0221725#ent", "<e2>"], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0221725", "name": "C0221725#ent", "pos": [28, 29]}}
{"token": ["Denopamine", ",", "C0001644#ent", "<e1>", "decreased", "her", "high", "pulmonary", "arterial", "pressure", "improved", "C0013404#ent", "<e2>", "on", "exercise", "after", "long", "term", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [11, 12]}}
{"token": ["The", "protease", "hydrolyzed", "hide", "power", "azure", "and", "casein", ",", "but", "it", "had", "no", "effect", "C0009325#ent", "<e1>", ",", "hyaluronic", "acid", "complement", "or", "synthetic", "substrates", "thrombin", ",", "plasmin", "or", "C0752224#ent", "<e2>", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0752224", "name": "C0752224#ent", "pos": [27, 28]}}
{"token": ["Four", "patients", "with", "metastatic", "renal", "cell", "carcinoma", "high", "serum", "levels", "of", "C1413766#ent", "<e1>", "and", "IL-6", "who", "had", "experienced", "disease", "progression", "C1522405#ent", "<e2>", "were", "retreated", "with", "the", "same", "C1522405#ent", "<e2>", "regimen", "combined", "with", "thalidomide", "300", "mg", "p.o", "."], "h": {"id": "C1413766", "name": "C1413766#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [20, 21]}}
{"token": ["Pirbuterol", "is", "a", "C0001640#ent", "<e1>", "differs", "structurally", "from", "C0543495#ent", "<e2>", "in", "the", "substitution", "of", "a", "pyridine", "ring", "the", "benzene", "ring"], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [8, 9]}}
{"token": ["In", "our", "experiments", "hyperthyroidism", "has", "a", "sensitizing", "influence", "on", "vascular", "responses", "induced", "by", "the", "C0001640#ent", "<e1>", "isoproterenol", "and", "the", "selective", "beta", "2-adrenoceptor", "C0543495#ent", "<e2>", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [22, 23]}}
{"token": ["The", "results", "demonstrate", "that", "short-term", "exposure", "to", "environmentally", "relevant", "concentrations", "of", "EDC", "mixtures", "can", "interfere", "with", "the", "lysosomal", "function", "redox-related", "C0014442#ent", "<e1>", "activities", "and", "C0812327#ent", "<e2>", "mussel", "digestive", "gland", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [24, 25]}}
{"token": ["Previous", "studies", "of", "C0567085#ent", "<e1>", "vascular", "rings", "in", "vitro", "that", "direct", "uterine", "vasoconstriction", "C0014479#ent", "<e2>", "is", "reduced", "during", "pregnancy", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014479", "name": "C0014479#ent", "pos": [13, 14]}}
{"token": ["Beef", "spleen", "kidney", ",", "and", "C0771711#ent", "<e1>", "give", "good", "responses", "but", "not", "up", "to", "C0007332#ent", "<e2>", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [14, 15]}}
{"token": ["A", "double-strand", "DNA", "break", "introduced", "at", "a", "specific", "site", "within", "the", "C0022959#ent", "<e1>", "plasmid", "pUC18", "using", "one", "of", "several", "restriction", "C3540772#ent", "<e2>", ",", "and", "the", "plasmid", "exposed", "to", "nuclear", "extracts", "human", "cell", "lines"], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [20, 21]}}
{"token": ["There", "appears", "to", "be", "no", "evident", "similarity", "between", "this", "and", "the", "Escherichia", "coli", "C0022959#ent", "<e1>", "sequence", ",", "thus", "suggesting", "that", "the", "two", "C3540772#ent", "<e2>", "have", "analogous", "function", ",", "but", "are", "not", "homologous", "."], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [22, 23]}}
{"token": ["Delivery", "verification", "show", "that", "C3714496#ent", "<e1>", "is", "less", "sensitive", "to", "tongue", "and", "groove", "effects", "C1413903#ent", "<e2>", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413903", "name": "C1413903#ent", "pos": [14, 15]}}
{"token": ["A", "study", "was", "performed", "in", "order", "to", "assess", "the", "capabilities", "of", "C3714496#ent", "<e1>", "as", "compared", "to", "fixed", "collimator", "angle", "C1413903#ent", "<e2>", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413903", "name": "C1413903#ent", "pos": [19, 20]}}
{"token": ["In", "the", "presence", "of", "Hck", ",", "C3273837#ent", "<e1>", "induced", "the", "accumulation", "of", "an", "immature", "under-N-glycosylated", "C0016053#ent", "<e2>", "at", "the", "Golgi", ",", "thereby", "down-regulating", "C0016053#ent", "<e2>", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016053", "name": "C0016053#ent", "pos": [15, 16]}}
{"token": ["Use", "of", "these", "cell", "lines", "that", "Rac", "is", "involved", "in", "both", "platelet-derived", "growth", "factor-stimulated", "membrane", "ruffling", "and", "the", "activation", "of", "C1335645#ent", "<e1>", "but", "not", "in", "the", "activation", "of", "C1705341#ent", "<e2>", "."], "h": {"id": "C1335645", "name": "C1335645#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [28, 29]}}
{"token": ["The", "subjects", "were", "orally", "received", "antiviral", "(", "C0297882#ent", "<e1>", ")", ",", "tricyclic", "antidepressant", "amitriptyline", ")", ",", "and", "C0728960#ent", "<e2>", "(", "ibuprofen", ")", "as", "the", "standard", "treatment", "the", "group", "1"], "h": {"id": "C0297882", "name": "C0297882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [17, 18]}}
{"token": ["Mutations", "of", "the", "KCNJ2", "gene", "encoding", "the", "C1416548#ent", "<e1>", "Kir2.1", "were", "previously", "shown", "to", "cause", "C0039496#ent", "<e2>", "AS", ")", ",", "a", "multisystem", "disease", "manifesting", "with", "developmental", "abnormalities", "cardiac", "arrhythmias", "periodic", "paralyses"], "h": {"id": "C1416548", "name": "C1416548#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039496", "name": "C0039496#ent", "pos": [15, 16]}}
{"token": ["Further", "characterization", "of", "these", "binding", "sites", "that", "the", "alpha", "2-adrenergic", "receptor", "of", "the", "alpha", "2A", "subtype", "since", "prazosin", "and", "C0052258#ent", "<e1>", "bound", "with", "low", "affinities", "and", "C0030071#ent", "<e2>", "bound", "with", "high", "affinity", "."], "h": {"id": "C0052258", "name": "C0052258#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0030071", "name": "C0030071#ent", "pos": [26, 27]}}
{"token": ["There", "was", "less", "C0025376#ent", "<e1>", "used", "in", "the", "C1422793#ent", "<e2>", "group", "."], "h": {"id": "C0025376", "name": "C0025376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422793", "name": "C1422793#ent", "pos": [8, 9]}}
{"token": ["Radicals", "situated", "only", "on", "alkyl", "groups", "to", "the", "C0524928#ent", "<e1>", "observed", "for", "dimethyl", "acetamide", "trimethyl", "acetamide", "C0054310#ent", "<e2>", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0054310", "name": "C0054310#ent", "pos": [16, 17]}}
{"token": ["Osteosarcoma", "cells", "expressing", "C2348848#ent", "<e1>", "but", "not", "expressing", "C1412362#ent", "<e2>", "were", "unable", "to", "synthesize", "leukotrienes", "."], "h": {"id": "C2348848", "name": "C2348848#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412362", "name": "C1412362#ent", "pos": [8, 9]}}
{"token": ["We", "were", "able", "to", "interrupt", "C0751495#ent", "<e1>", "(", "including", "status", "epilepticus", "by", "application", "of", "C0239377#ent", "<e2>", "dorsiflexion", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "co-transfection", "of", "C2699128#ent", "<e1>", "with", "dominant-negative", "Cdc42", "and", "C0285558#ent", "<e2>", ",", "or", "constitutively", "active", "Rho", "suppressed", "morphological", "effects", "C2699128#ent", "<e1>", "."], "h": {"id": "C2699128", "name": "C2699128#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [10, 11]}}
{"token": ["The", "P2Y-purinoceptor", "agonist", "2-methylthio-ATP", "(", "1", "-", "100", "microM", ")", "reduced", "C3887648#ent", "<e1>", "overflow", ",", "an", "effect", "prevented", "by", "the", "C2936574#ent", "<e2>", "cibacron", "blue", "3GA", "100", "microM", ")", "and", "suramin", "(", "100", "microM", ")", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2936574", "name": "C2936574#ent", "pos": [20, 21]}}
{"token": ["C0455988#ent", "<e1>", "becoming", "a", "predominant", "form", "of", "C0020305#ent", "<e2>", "to", "the", "declining", "incidence", "of", "immune", "hydrops", "fetalis", "by", "Rh", "isoimmunization"], "h": {"id": "C0455988", "name": "C0455988#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [7, 8]}}
{"token": ["Engraftment", "was", "achieved", "shortly", "after", "C0027947#ent", "<e1>", "nadir", ",", "and", "C0856825#ent", "<e2>", "GVHD", ")", "has", "been", "well", "controlled", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0856825", "name": "C0856825#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "testosterone", "propionate", "C1416805#ent", "<e1>", ")", "pellets", "(", "15", "mg", ")", "and/or", "C1418938#ent", "<e2>", "(", "50", "IU/kg", "body", "weight", "daily", "X", "5", ".", ")"], "h": {"id": "C1416805", "name": "C1416805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [14, 15]}}
{"token": ["The", "monoclonal", "antibodies", "GP", "Ib", "6D1", ")", "and", "C0040015#ent", "<e1>", "10E5", ")", "did", "not", "inhibit", "the", "binding", "of", "125I-PAP", "C1853155#ent", "<e2>", "to", "platelets", "."], "h": {"id": "C0040015", "name": "C0040015#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1853155", "name": "C1853155#ent", "pos": [19, 20]}}
{"token": ["It", "is", "noteworthy", "that", "C0011777#ent", "<e1>", "alone", "exerts", "a", "positive", "effect", "on", "C1366496#ent", "<e2>", "expression", "in", "PS", "and", "a", "negative", "one", "in", "RS", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366496", "name": "C1366496#ent", "pos": [12, 13]}}
{"token": ["When", "PS", "were", "treated", "with", "C0011777#ent", "<e1>", "(", "Dex", ")", ",", "a", "similar", "enhancement", "of", "the", "C1366496#ent", "<e2>", "transcript", "level", "was", "observed", ",", "whereas", "an", "inhibitory", "effect", "was", "recorded", "for", "RS", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366496", "name": "C1366496#ent", "pos": [16, 17]}}
{"token": ["Additionally", ",", "we", "analyzed", "C1335528#ent", "<e1>", "expression", "in", "five", "HCC", "cell", "lines", "identified", "distinct", "C1417020#ent", "<e2>", "expression", "patterns", "in", "different", "cell", "lines"], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417020", "name": "C1417020#ent", "pos": [14, 15]}}
{"token": ["After", "acid", "hydrolysis", "urine", "was", "conducted", ",", "C0070570#ent", "<e1>", "and", "p-cresol", "were", "extracted", "with", "C0058159#ent", "<e2>", "derivatized", "with", "4-(N-phthalimidinyl)benzenesulfonyl", "chloride", "give", "fluorescent", "sulfonyl", "esters", "."], "h": {"id": "C0070570", "name": "C0070570#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0058159", "name": "C0058159#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "iSDR", "was", "enhanced", "by", "C1335823#ent", "<e1>", "and", "recJ", "mutations", "inactivate", "the", "C0059946#ent", "<e2>", "activity", "of", "the", "RecBCD", "enzyme", "the", "RecJ", "exonuclease", "activity", "respectively", "."], "h": {"id": "C1335823", "name": "C1335823#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [14, 15]}}
{"token": ["Genetic", "defects", "these", "steps", "are", "defined", "as", "cbl", "complementation", "groups", "of", "which", "cblC", ",", "cblD", "(", "described", "in", "only", "two", "siblings", ")", ",", "and", "C1848578#ent", "<e1>", "are", "associated", "with", "homocystinuria", "and", "C0268583#ent", "<e2>"], "h": {"id": "C1848578", "name": "C1848578#ent", "pos": [24, 25]}, "relation": "has_manifestation", "t": {"id": "C0268583", "name": "C0268583#ent", "pos": [31, 32]}}
{"token": ["In", "addition", ",", "although", "hepatic", "maturation", "induced", "by", "C3887694#ent", "<e1>", "depends", "on", "STAT3", ",", "C1420314#ent", "<e2>", "failed", "to", "activate", "STAT3", "and", "HGF-induced", "differentiation", "was", "independent", "of", "STAT3", "."], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [14, 15]}}
{"token": ["C3887694#ent", "<e1>", "in", "combination", "with", "prostaglandin", "E(2)", "a", "powerful", "C1420314#ent", "<e2>", "inductor", ",", "led", "to", "an", "additive", "effect"], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [9, 10]}}
{"token": ["A", "significantly", "greater", "proportion", "of", "C1418735#ent", "<e1>", "subjects", "(", "89.1", "%", ")", "completed", "treatment", "than", "did", "C1832586#ent", "<e2>", "subjects", "(", "53.6", "%", ")", "."], "h": {"id": "C1418735", "name": "C1418735#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1832586", "name": "C1832586#ent", "pos": [16, 17]}}
{"token": ["To", "investigate", "their", "physiological", "functions", "we", "generated", "mice", "lacking", "the", "Mnk1", "or", "C2984599#ent", "<e1>", "gene", "or", "both", ";", "the", "resulting", "C4284124#ent", "<e2>", "mice", "were", "viable", ",", "fertile", ",", "and", "developed", "normally", "."], "h": {"id": "C2984599", "name": "C2984599#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [20, 21]}}
{"token": ["Two", "dimensional", "electrophoresis", "that", "recombinant", "C1454853#ent", "<e1>", "from", "S2betaSEC/GalT-ST", "cells", "had", "a", "lower", "isoelectric", "point", "to", "C1454853#ent", "<e1>", "from", "control", "S2betaSEC", "cells", "(", "C1419718#ent", "<e1>", "only", "with", "beta-secretase", "cDNA", "."], "h": {"id": "C1454853", "name": "C1454853#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419718", "name": "C1419718#ent", "pos": [23, 24]}}
{"token": ["C3502322#ent", "<e1>", "and", "AMCase", "are", "true", "C3540790#ent", "<e2>", "which", "hydrolyse", "chitin", "and", "have", "a", "C-terminal", "chitin-binding", "domain", "."], "h": {"id": "C3502322", "name": "C3502322#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [6, 7]}}
{"token": ["Fractions", "were", "analyzed", "for", "protein", ",", "alpha-amylase", "(", "C3502322#ent", "<e1>", "and", "5'-nucleotidase", "(", "EC", "3.1.3.5", ")", "as", "marker", "C3540790#ent", "<e2>", "for", "zymogen", "granule", "content", "and", "membranes", ",", "respectively", "."], "h": {"id": "C3502322", "name": "C3502322#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [18, 19]}}
{"token": ["The", "high", "expression", "of", "both", "C1846919#ent", "<e1>", "and", "receptors", "for", "LPA", "in", "numerous", "tumor", "cell", "has", "produced", "substantial", "interest", "in", "exploring", "C1846919#ent", "<e1>", "as", "an", "C1516468#ent", "<e1>", "."], "h": {"id": "C1846919", "name": "C1846919#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1516468", "name": "C1516468#ent", "pos": [25, 26]}}
{"token": ["Resuscitation", "was", "performed", "using", "open-chest", "heart", "massage", "C0054040#ent", "<e1>", "for", "ventricular", "tachycardia", "and", "epinephrine", "with", "C1161352#ent", "<e2>", "for", "electromechanical", "dissociation", "bradycardia", "."], "h": {"id": "C0054040", "name": "C0054040#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [15, 16]}}
{"token": ["This", "response", "was", "blocked", "by", "tetrodotoxin", ",", "guanethidine", "and", "C0054040#ent", "<e1>", "but", "not", "by", "C1161352#ent", "<e2>", "."], "h": {"id": "C0054040", "name": "C0054040#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [14, 15]}}
{"token": ["MA", "predicts", "cardiovascular", "disease", "C0011860#ent", "<e1>", "patients", "with", "increased", "von", "Willebrand", "factor", "C1336938#ent", "<e2>", ")", "plasma", "levels", "are", "hypothesized", "to", "reflect", "endothelial", "dysfunction"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [12, 13]}}
{"token": ["The", "disruption", "of", "brightness", "discrimination", "PCP", "was", "not", "reversed", "by", "C0033229#ent", "<e1>", ",", "haloperidol", ",", "diazepam", ",", "C0033497#ent", "<e2>", "or", "apomorphine", "at", "doses", "which", "reduced", "the", "locomotor", "stimulation", "by", "PCP", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "glycogen", "synthase", "kinase", "3beta", "C1423043#ent", "<e1>", ")", "contributes", "to", "pai-1", "repression", "by", "phosphorylating", "and", "stabilizing", "C1417821#ent", "<e2>", "which", "can", "be", "blocked", "by", "lithium", "."], "h": {"id": "C1423043", "name": "C1423043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417821", "name": "C1417821#ent", "pos": [17, 18]}}
{"token": ["The", "C0206157#ent", "<e1>", "and", "malabsorption", "improved", "with", "C3536709#ent", "<e2>", "treatment", "."], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [7, 8]}}
{"token": ["The", "C0206157#ent", "<e1>", "is", "not", "mediated", "by", "the", "patients", "'", "C3536709#ent", "<e2>", "and", "nutritional", "status", "liver", "dysfunction", "neurological", "changes", "and", "there", "is", "little", "correlation", "between", "alcoholic", "myopathy", "alcohol", "intake"], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [10, 11]}}
{"token": ["The", "last", "115", "amino", "acids", "Uba2", ",", "which", "contains", "an", "82-amino", "acid", "region", "not", "present", "in", "previously", "characterized", "E1", "C3540790#ent", "<e1>", ",", "is", "sufficient", "for", "the", "interaction", "with", "C1538823#ent", "<e2>", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1538823", "name": "C1538823#ent", "pos": [28, 29]}}
{"token": ["RPK118", "contains", "several", "functional", "domains", "sequences", "are", "homologous", "to", "other", "known", "C0086376#ent", "<e1>", "including", "the", "phox", "homology", "domain", "C1540054#ent", "<e2>", "2", "domains", "and", "is", "shown", "to", "be", "a", "member", "of", "an", "evolutionarily", "highly", "conserved", "gene", "family"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1540054", "name": "C1540054#ent", "pos": [18, 19]}}
{"token": ["Repression", "by", "both", "C1538149#ent", "<e1>", "and", "C1867727#ent", "<e2>", "is", "sensitive", "to", "the", "histone", "deacetylase", "inhibitor", "TSA", ",", "and", "C1538149#ent", "<e1>", "was", "previously", "shown", "to", "interact", "physically", "with", "HDAC1", ",", "a", "class", "I", "histone", "deacetylase"], "h": {"id": "C1867727", "name": "C1867727#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [3, 4]}}
{"token": ["C1867727#ent", "<e1>", "contains", "a", "second", ",", "RA-resistant", "binding", "site", "the", "C1538149#ent", "<e2>", "amino-terminal", "region"], "h": {"id": "C1867727", "name": "C1867727#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggested", "that", "concentrative", "accumulation", "of", "C0130360#ent", "<e1>", "was", "dependent", "upon", "the", "mitochondrial", "transmembrane", "gradient", "rather", "than", "C1705556#ent", "<e2>", ",", "although", "direct", "implication", "of", "C1705556#ent", "<e2>", "could", "not", "be", "excluded", "."], "h": {"id": "C0130360", "name": "C0130360#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [18, 19]}}
{"token": ["This", "protein", "shares", "approximately", "50", "%", "amino", "acid", "sequence", "homology", "with", "the", "amino", "acid", "transporters", "mouse", "mNAT", "and", "its", "orthologs", ",", "rat", "C1442750#ent", "<e1>", "and", "human", "g17", ",", "and", "mouse", "GlnT/ATA1", "and", "C1414993#ent", "<e2>", "."], "h": {"id": "C1442750", "name": "C1442750#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1414993", "name": "C1414993#ent", "pos": [32, 33]}}
{"token": ["Urine", "podocytes", "absent", "in", "normal", "control", "nonglomerular", "diseases", "as", "urinary", "tract", "infection", "nonglomerular", "hematuria", ",", "and", "glomerular", ",", "C1290884#ent", "<e1>", "as", "minimal", "change", "C0027726#ent", "<e2>", "membranous", "nephropathy"], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [23, 24]}}
{"token": ["Our", "results", "in", "corneal", "epithelium", "consistent", "with", "reports", "from", "other", "investigators", "showing", "that", "C1705527#ent", "<e1>", "facilitates", "both", "C0812305#ent", "<e2>", "migration", "."], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812305", "name": "C0812305#ent", "pos": [17, 18]}}
{"token": ["In", "renal", "cultured", "cells", "either", "incubated", "for", "several", "days", "with", "nanomolar", "concentrations", "of", "C0029904#ent", "<e1>", "or", "transfected", "with", "the", "hypertensive", "C1412230#ent", "<e2>", "genetic", "variant", "the", "Na-K", "pump", "results", "enhanced", "."], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412230", "name": "C1412230#ent", "pos": [20, 21]}}
{"token": ["Experimental", "and", "clinical", "evidence", "that", "Endogenous", "C0029904#ent", "<e1>", "(", "EO", ")", "and", "C1412230#ent", "<e2>", "polymorphism", "play", "a", "pathogenetic", "role", "in", "hypertension", "and", "related", "organ", "complications", "."], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412230", "name": "C1412230#ent", "pos": [12, 13]}}
{"token": ["The", "inhibitory", "effect", "of", "C0066561#ent", "<e1>", "on", "the", "binding", "of", "C0022616#ent", "<e2>", "was", "more", "marked", "than", "on", "the", "binding", "of", "[3H]5-HT", "and", "[3H]8-OH-DPAT", ",", "and", "was", "non-competitive", "."], "h": {"id": "C0066561", "name": "C0066561#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [10, 11]}}
{"token": ["C0066561#ent", "<e1>", "inhibited", "the", "bindings", "of", "[3H]5-HT", ",", "[3H]8-OH-DPAT", "and", "C0022616#ent", "<e2>", "in", "the", "hippocampus", "."], "h": {"id": "C0066561", "name": "C0066561#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [10, 11]}}
{"token": ["In", "conclusion", ",", "the", "frequency", "of", "mutations", "in", "the", "C1418270#ent", "<e1>", "certain", "populations", "might", "be", "high", "enough", "to", "cause", "C0002085#ent", "<e2>", "heterogeneity", "in", "the", "same", "sibship", "."], "h": {"id": "C1418270", "name": "C1418270#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "membrane", "permeabilization", "not", "inhibited", "by", "SB203580", "and", "SB202190", ",", "two", "inhibitors", "of", "C1120843#ent", "<e1>", "nor", "by", "intracellular", "C0043775#ent", "<e2>", ",", "which", "blocks", "ATP-induced", "Ca2", "+", "signals", "."], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0043775", "name": "C0043775#ent", "pos": [20, 21]}}
{"token": ["We", "have", "generated", "transgenic", "mice", "a", "functional", "C1261253#ent", "<e1>", "compared", "the", "urinary", "levels", "acetylated", "folate", "metabolite", "para-aminobenzoylglutamate", "in", "C0796518#ent", "<e2>", "knockout", "and", "C0796518#ent", "<e2>", "wild-type", "mice", "."], "h": {"id": "C1261253", "name": "C1261253#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0796518", "name": "C0796518#ent", "pos": [18, 19]}}
{"token": ["A", "genetic", "polymorphism", "the", "C1261253#ent", "<e1>", "encoding", "for", "C0796518#ent", "<e2>", "NAT2", ")", ",", "segregates", "individuals", "into", "rapid", ",", "intermediate", "or", "slow", "acetylator", "phenotypes", "."], "h": {"id": "C1261253", "name": "C1261253#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0796518", "name": "C0796518#ent", "pos": [8, 9]}}
{"token": ["In", "vitro", "assays", "demonstrated", "that", "C3272787#ent", "<e1>", "effectively", "inhibits", "CERK", "without", "inhibiting", "sphingosine", "kinase", "C0113519#ent", "<e2>"], "h": {"id": "C3272787", "name": "C3272787#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0113519", "name": "C0113519#ent", "pos": [14, 15]}}
{"token": ["Insulin-mediated", "C1333257#ent", "<e1>", "expression", "was", "preceded", "by", "inducible", "C1705516#ent", "<e2>", "(", "iNOS", ")", "induction", "and", "cGMP", "production", "."], "h": {"id": "C1333257", "name": "C1333257#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705516", "name": "C1705516#ent", "pos": [8, 9]}}
{"token": ["The", "IP3", "level", "induced", "by", "C0072186#ent", "<e1>", "slightly", "lower", "than", "that", "induced", "by", "C1333574#ent", "<e2>", "."], "h": {"id": "C0072186", "name": "C0072186#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [13, 14]}}
{"token": ["In", "the", "absence", "of", "extracellular", "Ca2", "+", ",", "thapsigargin", ",", "a", "potent", "inhibitor", "of", "endoplasmic", "reticulum", "Ca2+-ATPase", "induced", "an", "increase", "in", "[Ca2+]i", "even", "after", "C0072186#ent", "<e1>", "stimulation", ",", "but", "not", "after", "C1333574#ent", "<e2>", "."], "h": {"id": "C0072186", "name": "C0072186#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [31, 32]}}
{"token": ["Oral", "contraceptive", "pills", "C3539565#ent", "<e1>", ")", "are", "usually", "the", "first", "choice", "of", "treatment", "for", "C0032460#ent", "<e2>", "PCOS", ")", ",", "when", "fertility", "is", "not", "desired", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [14, 15]}}
{"token": ["C1334533#ent", "<e1>", ",", "a", "protein", "kinase", "complex", "of", "cyclin", "and", "p34cdc2", "subunits", "promotes", "the", "C1422270#ent", "<e2>", "to", "M", "phase", "transition", "eukaryotic", "cells"], "h": {"id": "C1334533", "name": "C1334533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422270", "name": "C1422270#ent", "pos": [14, 15]}}
{"token": ["The", "behavioral", "effect", "of", "morphine", "was", "blocked", "by", "C2343921#ent", "<e1>", "injection", ",", "whereas", "the", "physiological", "effect", "C0147448#ent", "<e2>", "was", "blocked", "by", "naloxone", "."], "h": {"id": "C2343921", "name": "C2343921#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0147448", "name": "C0147448#ent", "pos": [16, 17]}}
{"token": ["Whereas", "C2343921#ent", "<e1>", "significantly", "reduced", "both", "C0147448#ent", "<e2>", "and", "NalBzoH", "hyperphagia", ",", "Nor-BNI", "blocked", "U50,448H", ",", "but", "not", "NalBzoH", "hyperphagia", "."], "h": {"id": "C2343921", "name": "C2343921#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0147448", "name": "C0147448#ent", "pos": [6, 7]}}
{"token": ["C3810616#ent", "<e1>", "was", "covalently", "immobilized", "onto", "the", "SPR", "sensor", "chip", "and", "C1420371#ent", "<e2>", "measurement", "using", "the", "PSP2-immobilized", "chip", "for", "various", "concentrations", "of", "porphyrin", "was", "carried", "out", "."], "h": {"id": "C3810616", "name": "C3810616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420371", "name": "C1420371#ent", "pos": [11, 12]}}
{"token": ["The", "literature", "establishes", "a", "potential", "link", "between", "the", "function", "of", "C0259969#ent", "<e1>", "in", "the", "biological", "actions", "C0001962#ent", "<e2>", "and", "the", "reduced", "pterin", "cofactor", "for", "synthesis", "of", "certain", "neurotransmitters", "."], "h": {"id": "C0259969", "name": "C0259969#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [16, 17]}}
{"token": ["C0085096#ent", "<e1>", "PAD", ")", "is", "associated", "with", "C0007220#ent", "<e2>", "can", "significantly", "impair", "patients", "'", "health", "status"], "h": {"id": "C0085096", "name": "C0085096#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007220", "name": "C0007220#ent", "pos": [7, 8]}}
{"token": ["The", "results", "showed", "that", "vinyl", "carbamate", "C0041964#ent", "<e1>", "more", "immunosuppressive", "compared", "to", "C0041964#ent", "<e1>"], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041964", "name": "C0041964#ent", "pos": [6, 7]}}
{"token": ["A", "C1416671#ent", "<e1>", "levels", "of", "which", "correlate", "with", "C0242723#ent", "<e2>", "levels", ",", "is", "present", "in", "the", "plasma", "of", "rats", "acutely", "infected", "with", "Trypanosoma", "brucei", "brucei"], "h": {"id": "C1416671", "name": "C1416671#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242723", "name": "C0242723#ent", "pos": [8, 9]}}
{"token": ["C1260873#ent", "<e1>", "present", "as", "an", "C0742343#ent", "<e2>"], "h": {"id": "C1260873", "name": "C1260873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0742343", "name": "C0742343#ent", "pos": [5, 6]}}
{"token": ["We", "also", "review", "the", "glucocerebrosidase", "natural", "activator", "designated", "C1418975#ent", "<e1>", "mutations", "in", "its", "C0079429#ent", "<e2>", ",", "associated", "with", "Gaucher", "disease"], "h": {"id": "C1418975", "name": "C1418975#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["When", "C0360097#ent", "<e1>", "was", "used", ",", "the", "C0000737#ent", "<e2>", "reduced", "by", "38.9", "and", "51.4", "%", "compared", "with", "placebo", "and", "no", "local", "injection", "respectively", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [7, 8]}}
{"token": ["Although", "two", "ferredoxins", "and", "four", "C0015857#ent", "<e1>", "been", "identified", "so", "far", ",", "only", "one", "C1414575#ent", "<e2>", "found", "in", "the", "cluster", "of", "CYP147F1", "in", "S.", "peucetius", "."], "h": {"id": "C0015857", "name": "C0015857#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414575", "name": "C1414575#ent", "pos": [14, 15]}}
{"token": ["The", "electrophysiologic", "changes", "after", "ventricular", "dilatation", "a", "degree", "that", "increases", "left", "ventricular", "pressure", "a", "clinically", "relevant", "range", "can", "be", "influenced", "by", "the", "C3537389#ent", "<e1>", "streptomycin", "but", "not", "by", "specific", "C0006684#ent", "<e2>"], "h": {"id": "C3537389", "name": "C3537389#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [29, 30]}}
{"token": ["Further", "signalling", "molecules", "to", "regulate", "paracellular", "permeability", "C0752065#ent", "<e1>", ",", "both", "conventional", "and", "C0086376#ent", "<e2>", "MAP", "kinases", "other", "protein", "kinases"], "h": {"id": "C0752065", "name": "C0752065#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["Only", "complete", "fractures", "of", "the", "C0035086#ent", "<e1>", "caused", "a", "significant", "reduction", "of", "C0162298#ent", "<e2>"], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162298", "name": "C0162298#ent", "pos": [12, 13]}}
{"token": ["We", "speculate", "that", "C0027235#ent", "<e1>", "prove", "beneficial", "for", "the", "treatment", "of", "rhinorrhea", "in", "C0035457#ent", "<e2>"], "h": {"id": "C0027235", "name": "C0027235#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [13, 14]}}
{"token": ["These", "data", "indicate", "that", "C0027235#ent", "<e1>", "decreases", "the", "rhinorrhea", "of", "C0035457#ent", "<e2>"], "h": {"id": "C0027235", "name": "C0027235#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggest", "that", "C1424250#ent", "<e1>", "exerts", "a", "C1370824#ent", "<e2>", "through", "activation", "of", "AT1", "receptors", "subsequent", "acceleration", "of", "phosphoinositide", "hydrolysis"], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1370824", "name": "C1370824#ent", "pos": [8, 9]}}
{"token": ["The", "second", "promoter", ",", "C3811665#ent", "<e1>", ",", "is", "located", "within", "the", "C0029073#ent", "<e2>", "just", "upstream", "of", "the", "galE", "gene"], "h": {"id": "C3811665", "name": "C3811665#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [11, 12]}}
{"token": ["The", "\u03b1-and", "\u03b2-subunits", "of", "phycocyanin", "and", "C0051214#ent", "<e1>", "and", "also", "both", "C0599220#ent", "<e2>", "of", "ribulose-1,5-bisphosphate", "carboxylase-oxygenase", "RuBPCase", ")", "were", "identified", "with", "the", "help", "of", "specific", "antibodies", "as", "translation", "products", "of", "non-polyadenylated", "mRNA", "."], "h": {"id": "C0051214", "name": "C0051214#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [11, 12]}}
{"token": ["Competition", "assays", "in", "which", "the", "binding", "of", "radiolabeled", "tropoelastin", "was", "inhibited", "by", "excess", "unlabeled", "C0013765#ent", "<e1>", "peptides", ",", "but", "not", "by", "other", "C0086376#ent", "<e2>", ",", "established", "the", "specificity", "of", "the", "interaction", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "the", "effect", "of", "inhibiting", "nuclear", "factor-kappa", "B", "NF-kappaB", ")", "on", "C0011881#ent", "<e1>", "DN", ")", "and", "mRNA", "expression", "of", "fibronectin", "(", "C1706331#ent", "<e2>", ")", "in", "diabetic", "kidneys", "."], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [22, 23]}}
{"token": ["We", "investigated", "the", "effect", "of", "meropenem", "(", "C3889714#ent", "<e1>", ")", "on", "the", "disposition", "kinetics", "of", "C0080356#ent", "<e2>", "(", "VPA", ")", "and", "its", "metabolites", "in", "rabbits", "."], "h": {"id": "C3889714", "name": "C3889714#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0080356", "name": "C0080356#ent", "pos": [15, 16]}}
{"token": ["Recombinant", "timothy", "pollen", "profilin", "expressed", "in", "Escherichia", "coli", "a", "C0005220#ent", "<e1>", "shown", "to", "bind", "IgE", "from", "C0072074#ent", "<e2>", "patients", "similar", "to", "recombinant", "birch", "profilin", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0072074", "name": "C0072074#ent", "pos": [16, 17]}}
{"token": ["Monoclonal", "antibodies", "C1416713#ent", "<e1>", "(", "AE1/AE3", ")", "were", "applied", "as", "a", "C0033209#ent", "<e2>", ",", "using", "APAAP", "immunohistochemistry", "technique", "detect", "635", "lymph", "nodes", "45", "breast", "cancer", "patients", "with", "negative", "lymph", "nodes"], "h": {"id": "C1416713", "name": "C1416713#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033209", "name": "C0033209#ent", "pos": [11, 12]}}
{"token": ["In", "13", "patients", "admitted", "to", "a", "coronary", "care", "unit", "C0003195#ent", "<e1>", "safety", "of", "C0072869#ent", "<e2>", "a", "nonmatrix", "formulation", "were", "compared", "to", "placebo", "and", "quinidine", "sulfate"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [9, 10]}, "relation": "therapeutic_class_of", "t": {"id": "C0072869", "name": "C0072869#ent", "pos": [13, 14]}}
{"token": ["She", "experienced", "intermittent", "dizziness", "and", "C0746674#ent", "<e1>", "and", "was", "diagnosed", "as", "having", "severe", "C0002880#ent", "<e2>", "AIHA", ")", "."], "h": {"id": "C0746674", "name": "C0746674#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002880", "name": "C0002880#ent", "pos": [13, 14]}}
{"token": ["C0011859#ent", "<e1>", "a", "rare", "C0039082#ent", "<e2>", "characterized", "by", "lipoatrophy", "and", "insulin-resistant", "diabetes", "mellitus"], "h": {"id": "C0011859", "name": "C0011859#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [4, 5]}}
{"token": ["A", "21", "years", "old", "female", "patient", "with", "C0011859#ent", "<e1>", "a", "distinct", "C0039082#ent", "<e2>", "of", "insulin", "resistant", "diabetes", "mellitus", "loss", "of", "subcutaneous", "fat", "hepatosplenomegaly", ",", "hyperlipidemia", ",", "increased", "basal", "metabolic", ",", "subvalvular", "aortic", "stenosis", "cystic", "bone", "lesions", "described", "."], "h": {"id": "C0011859", "name": "C0011859#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [11, 12]}}
{"token": ["Facial", "and", "bulbar", "weakness", "C1836448#ent", "<e1>", "chewing", "and", "C0011168#ent", "<e2>", "recurrent", "aspiration", "and", "poor", "control", "oral", "secretions"], "h": {"id": "C1836448", "name": "C1836448#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [8, 9]}}
{"token": ["Both", "Pmt1p", "and", "Pmt2p", ",", "which", "do", "not", "transfer", "O-mannose", "to", "correctly", "folded", "C1537502#ent", "<e1>", ",", "participated", "in", "the", "O-mannosylation", "of", "C1414990#ent", "<e2>", "."], "h": {"id": "C1537502", "name": "C1537502#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414990", "name": "C1414990#ent", "pos": [21, 22]}}
{"token": ["Our", "results", "suggest", "that", "the", "clinical", "heterogeneity", "in", "C0268135#ent", "<e1>", "is", "due", "to", "different", "mutations", "in", "the", "C1705709#ent", "<e2>"], "h": {"id": "C0268135", "name": "C0268135#ent", "pos": [8, 9]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705709", "name": "C1705709#ent", "pos": [17, 18]}}
{"token": ["Twenty-four", "male", "and", "female", "hypertensives", ",", "aged", "33", "-", "77", "years", ",", "received", "either", "120", "mg", "C0145155#ent", "<e1>", "matched", "placebo", "daily", "for", "22", "days", "concomitantly", "with", "C0014025#ent", "<e2>", "."], "h": {"id": "C0145155", "name": "C0145155#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [26, 27]}}
{"token": ["Two", "cases", "are", "presented", "and", "a", "third", "is", "cited", "from", "the", "literature", "in", "which", "the", "onset", "of", "hyperthyroidism", "exacerbated", "C3714552#ent", "<e1>", "previously", "undiagnosed", "C3250443#ent", "<e2>"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [19, 20]}, "relation": "manifestation_of", "t": {"id": "C3250443", "name": "C3250443#ent", "pos": [23, 24]}}
{"token": ["Field", "trials", "the", "test", "bio-control", "agents", "were", "carried", "out", "in", "autumn", "and", "spring", "by", "adding", "dung", "from", "sheep", "infected", "with", "C0029471#ent", "<e1>", "(", "Teladorsagia", ")", "circumcincta", "to", "C0015230#ent", "<e2>", "of", "ryegrass/white", "clover", "."], "h": {"id": "C0029471", "name": "C0029471#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [27, 28]}}
{"token": ["Those", "cases", "consisted", "of", "7(47", "%", ")", "with", "C0339696#ent", "<e1>", "strabismus", ",", "and", "2(13", "%", ")", "with", "C0152189#ent", "<e2>"], "h": {"id": "C0339696", "name": "C0339696#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0152189", "name": "C0152189#ent", "pos": [17, 18]}}
{"token": ["Early", "detection", "C0151744#ent", "<e1>", "assessment", "of", "C3274794#ent", "<e2>", "and", "the", "ability", "to", "monitor", "for", "intracardiac", "air", "are", "among", "the", "most", "important", "roles", "of", "intraoperative", "transesophageal", "echocardiography"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3274794", "name": "C3274794#ent", "pos": [6, 7]}}
{"token": ["Huperzine", "A", "not", "affect", "spontaneous", "or", "evoked", "release", "of", "GABA", "and", "C0017789#ent", "<e1>", ",", "suggesting", "that", "this", "compound", "may", "be", "a", "pure", "C0008425#ent", "<e2>", "had", "no", "effect", "postsynaptic", "GABAA", "or", "AMPA", "receptors"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008425", "name": "C0008425#ent", "pos": [22, 23]}}
{"token": ["Blockade", "of", "C3538735#ent", "<e1>", "bioactivity", "inhibited", "and", "prevented", "inflammation", "in", "experimental", "gastritis", "colitis", ",", "C0019158#ent", "<e2>", ",", "and", "pancreatitis", "."], "h": {"id": "C3538735", "name": "C3538735#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [14, 15]}}
{"token": ["These", "data", "demonstrate", "that", "C1706384#ent", "<e1>", "expression", "is", "regulated", "by", "C2936882#ent", "<e2>", "and", "suggest", "that", "JUN-C", "could", "play", "a", "role", "in", "the", "activation", "of", "cell", "proliferation", "C2936882#ent", "<e2>", "."], "h": {"id": "C1706384", "name": "C1706384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [10, 11]}}
{"token": ["Two", "months", "later", ",", "the", "patient", "developed", "severe", "C0013404#ent", "<e1>", ",", "chylothorax", ",", "and", "C3854173#ent", "<e2>"], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "complexes", "of", "C0256103#ent", "<e1>", "bound", "to", "C1413107#ent", "<e2>", "and", "calreticulin", "were", "shown", "to", "be", "enzymically", "active", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413107", "name": "C1413107#ent", "pos": [8, 9]}}
{"token": ["To", "evaluate", "the", "safety", "profile", "and", "therapeutic", "value", "the", "combination", "of", "C0014921#ent", "<e1>", ",", "mitoxantrone", ",", "and", "C0078257#ent", "<e2>", "in", "the", "treatment", "of", "hormone-refractory", "prostate", "cancer"], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0078257", "name": "C0078257#ent", "pos": [17, 18]}}
{"token": ["Out", "of", "79", "patients", "treated", ",", "42", "had", "urosepsis", ",", "25", "developed", "C0520575#ent", "<e1>", "in", "pregnancy", ",", "12", "had", "complicating", "C1561643#ent", "<e2>"], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [20, 21]}}
{"token": ["The", "importance", "of", "uropathogenic", "Escherichia", "coli", "causing", "acute", "and", "recurrent", "C0520575#ent", "<e1>", "with", "the", "consequent", "morbidity", "of", "C1561643#ent", "<e2>", "well", "established", "."], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [17, 18]}}
{"token": ["Plasma", "endothelin-1", "(", "ET-1", ")", "and", "C1336938#ent", "<e1>", "vWF", ")", "concentrations", "following", "cold", "exposure", "52", "patients", "with", "C0034734#ent", "<e2>", "phenomenon", "were", "measured", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034734", "name": "C0034734#ent", "pos": [17, 18]}}
{"token": ["The", "material", "included", "37", "vibration-induced", "white", "finger", "(", "C1336938#ent", "<e1>", ")", "cases", ",", "five", "primary", "C0034734#ent", "<e2>", "cases", ",", "and", "37", "controls", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034734", "name": "C0034734#ent", "pos": [15, 16]}}
{"token": ["The", "protein", "is", "composed", "of", "a", "light", "inhibitory", "chain", "C1412376#ent", "<e1>", "and", "two", "C1420192#ent", "<e2>", "unknown", "function", "."], "h": {"id": "C1412376", "name": "C1412376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [13, 14]}}
{"token": ["Inter-alpha-trypsin", "inhibitor", "ITI", ")", "is", "a", "complex", "protein", "up", "of", "a", "light", "chain", "C1412376#ent", "<e1>", "and", "two", "C1420192#ent", "<e2>", "apparent", "Mr", "values", "96000", "and", "86000", "in", "SDS/PAGE", "in", "non-reducing", "conditions", ")", "."], "h": {"id": "C1412376", "name": "C1412376#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [17, 18]}}
{"token": ["Inter-alpha-trypsin", "inhibitor", "ITI", ")", "is", "a", "tight", "complex", "of", "three", "different", "proteins", ":", "C1412376#ent", "<e1>", "and", "two", "C1420192#ent", "<e2>", "H2", "."], "h": {"id": "C1412376", "name": "C1412376#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [17, 18]}}
{"token": ["This", "distribution", "pattern", "of", "C1418556#ent", "<e1>", "is", "identical", "to", "that", "of", "C0127014#ent", "<e2>", "reported", "previously", "."], "h": {"id": "C1418556", "name": "C1418556#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0127014", "name": "C0127014#ent", "pos": [11, 12]}}
{"token": ["Amino", "acid", "sequences", "internal", "peptides", "from", "rat", "C1418556#ent", "<e1>", "matched", "with", "corresponding", "sequence", "stretches", "of", "mouse", "C0127014#ent", "<e2>", "."], "h": {"id": "C1418556", "name": "C1418556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0127014", "name": "C0127014#ent", "pos": [16, 17]}}
{"token": ["Six", "of", "the", "seven", "C0096069#ent", "<e1>", "been", "shown", "to", "dephosphorylate", "C0082529#ent", "<e2>", "ERK", ")", "."], "h": {"id": "C0096069", "name": "C0096069#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [10, 11]}}
{"token": ["Methotrexate", "(", "C1417487#ent", "<e1>", ")", "has", "the", "potential", "of", "eradicating", "small", "infiltrations", "leukemic", "cells", "the", "C0018050#ent", "<e2>", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [15, 16]}}
{"token": ["In", "one", "type", ",", "the", "C1563751#ent", "<e1>", "a", "single-copy", "intact", "C0079429#ent", "<e2>", "and", "in", "the", "other", ",", "the", "genes", "exist", "as", "multiple", "pseudogenes", "a", "Y/autosome", "fusion", "chromosome", "."], "h": {"id": "C1563751", "name": "C1563751#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}}
{"token": ["C1333673#ent", "<e1>", "immunoreactive", "material", "with", "an", "approximate", "mass", "80", "C0026691#ent", "<e2>", "was", "subjected", "to", "isoelectric", "focusing", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026691", "name": "C0026691#ent", "pos": [9, 10]}}
{"token": ["C1527231#ent", "<e1>", "is", "an", "C1138434#ent", "<e2>", "by", "defects", "in", "the", "ABCD1", "gene", "which", "encodes", "the", "ALD", "protein", "a", "peroxisome", "membrane", "transport", "protein", "."], "h": {"id": "C1527231", "name": "C1527231#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1138434", "name": "C1138434#ent", "pos": [4, 5]}}
{"token": ["Enhanced", "tumor", "growth", "by", "constitutive", "activation", "of", "C0812228#ent", "<e1>", "in", "PTEN(+/+", ")", "cells", "also", "was", "reversed", "by", "C0796512#ent", "<e2>", "treatment", ",", "indicating", "that", "FRAP/mTOR", "functions", "downstream", "of", "C0812228#ent", "<e1>", "in", "tumorigenesis", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0796512", "name": "C0796512#ent", "pos": [17, 18]}}
{"token": ["EGF-R", "provides", "a", "scaffold", "needed", "for", "the", "activation", "of", "C0139880#ent", "<e1>", ",", "which", "leads", "to", "the", "activation", "of", "C0752312#ent", "<e2>", "."], "h": {"id": "C0139880", "name": "C0139880#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [18, 19]}}
{"token": ["A", "Pasteurella", "multocida", "human", "C1875400#ent", "<e1>", "was", "resistant", "to", "beta-lactams", "because", "of", "production", "of", "C0165919#ent", "<e2>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0165919", "name": "C0165919#ent", "pos": [14, 15]}}
{"token": ["In", "the", "C0004096#ent", "<e1>", "lung", "the", "altered", "expression", "of", "C2985420#ent", "<e2>", "CD80", ",", "CD86", ")", "by", "alveolar", "macrophages", "to", "T", "lymphocyte", "activation", "and", "expansion", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2985420", "name": "C2985420#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "it", "is", "suggested", "that", "the", "augmentation", "of", "the", "ACh-induced", "contractile", "response", "evoked", "by", "C0812246#ent", "<e1>", "might", "be", "mediated", "by", "an", "upregulation", "of", "C0812234#ent", "<e2>", "in", "rat", "bronchial", "smooth", "muscle"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [25, 26]}}
{"token": ["It", "has", "been", "suggested", "that", "the", "C0059438#ent", "<e1>", "EGCG", ")", "displays", "some", "C0935929#ent", "<e2>", "but", "the", "mechanism", "for", "EGCG", "insulin-enhancing", "effects", "is", "incompletely", "understood", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [12, 13]}}
{"token": ["We", "show", "that", "[3H]CD-270", "carboxylic", "acid", "binds", "specifically", "to", "C3273275#ent", "<e1>", ",", "whereas", "the", "C0001962#ent", "<e2>", "binds", "strongly", "to", "CRBP", "."], "h": {"id": "C3273275", "name": "C3273275#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [14, 15]}}
{"token": ["While", "a", "small", "percentage", "of", "patients", "with", "C0034155#ent", "<e1>", "have", "a", "constitutional", "defect", "this", "C0014442#ent", "<e2>", ",", "many", "with", "the", "acute", "idiopathic", "form", "an", "antibody", "to", "ADAMTS-13", ",", "affecting", "its", "ability", "to", "cleave", "vWf", "."], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["A", "C0012736#ent", "<e1>", "a", "60-year-old", "woman", "resulted", "in", "C1565489#ent", "<e2>", "medically", "uncontrollable", "hypertension", "."], "h": {"id": "C0012736", "name": "C0012736#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "provide", "a", "possibility", "that", "lymphocytes", "may", "gain", "access", "to", "C1413096#ent", "<e1>", "of", "spermatozoa", "inside", "the", "C1705312#ent", "<e2>", "and", "RT", "under", "physiological", "conditions", "mice", "."], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705312", "name": "C1705312#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "C0019880#ent", "<e1>", "with", "alpha-mercaptopropionylglycine", "has", "been", "associated", "with", "side", "effects", "traditional", "therapy", "with", "C0030817#ent", "<e2>", "."], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [15, 16]}}
{"token": ["46", "pregnancies", "in", "patients", "with", "C0019880#ent", "<e1>", "treated", "with", "high", "fluid", "intake", "alone", "or", "in", "combination", "with", "C0030817#ent", "<e2>", "resulted", "in", "41", "normal", "births"], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030817", "name": "C0030817#ent", "pos": [17, 18]}}
{"token": ["Tyrosine-containing", "peptides", "such", "as", "cholecystokinin-8-nonsulfate", ",", "C0886584#ent", "<e1>", "(Leu)enkephalin", "as", "acceptor", "substrates", "were", "effectively", "sulfated", "by", "the", "C2350558#ent", "<e2>", "enzyme", "."], "h": {"id": "C0886584", "name": "C0886584#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [17, 18]}}
{"token": ["Five", "questions", "were", "addressed", ":", "(", "1", ")", "Can", "amoxicillin", "remain", "the", "best", "initial", "antimicrobial", "agent", "treating", "C2698738#ent", "<e1>", "in", "the", "current", "period", "of", "increasing", "prevalence", "of", "C0043822#ent", "<e2>", "?"], "h": {"id": "C2698738", "name": "C2698738#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0043822", "name": "C0043822#ent", "pos": [27, 28]}}
{"token": ["These", "results", "may", "be", "attributed", "to", "inhibition", "of", "the", "systemic", "effects", "angiotensin", "II", "C2698414#ent", "<e1>", ")", "as", "well", "as", "to", "a", "local", "protective", "action", "the", "C0013227#ent", "<e2>", "against", "possible", "intramyocardial", "C2698414#ent", "<e1>", "production", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [13, 14]}}
{"token": ["C2917660#ent", "<e1>", "substitutions", "in", "some", "H3", ",", "C1415407#ent", "<e2>", "and", "H2b", "proteins", "are", "detected", "as", "internal", "cleavages", "the", "S1", "nuclease", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415407", "name": "C1415407#ent", "pos": [7, 8]}}
{"token": ["Their", "C2917660#ent", "<e1>", "composition", "shows", "similarities", "to", "that", "of", "the", "C1415407#ent", "<e2>", "and", "H2B", "histone", "and", "has", "a", "molecular", "weight", "15,500", "+", "/-", "300", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415407", "name": "C1415407#ent", "pos": [10, 11]}}
{"token": ["A", "procedure", "for", "studying", "5-hydroxytryptamine", "synthesis", "determining", "the", "rate", "of", "accumulation", "of", "5-hydroxytryptophan", "after", "administering", "m-hydroxybenzylhydrazine", ",", "an", "inhibitor", "of", "C1412028#ent", "<e1>", "and", "large", "doses", "of", "C0041260#ent", "<e2>", "was", "characterized", "."], "h": {"id": "C1412028", "name": "C1412028#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0041260", "name": "C0041260#ent", "pos": [26, 27]}}
{"token": ["An", "infectious", "disease", "C0039614#ent", "<e1>", "toxoid", "immunization", "preceded", "the", "onset", "of", "C0006246#ent", "<e2>", "in", "4", "cases", "."], "h": {"id": "C0039614", "name": "C0039614#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006246", "name": "C0006246#ent", "pos": [11, 12]}}
{"token": ["Studies", "have", "also", "connected", "MCP-1", ",", "C1413188#ent", "<e1>", ",", "and", "CD40L", "to", "C1565860#ent", "<e2>", "expression", "."], "h": {"id": "C1413188", "name": "C1413188#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [12, 13]}}
{"token": ["Although", "this", "patient", "had", "failed", "to", "respond", "thoroughly", "to", "C0032950#ent", "<e1>", ",", "the", "additional", "use", "of", "protease", "inhibitors", "induced", "a", "disease", "remission", "C0002878#ent", "<e2>"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [22, 23]}}
{"token": ["A", "7-year-old", "castrated", "male", "Whippet", "developed", "deep", "ulcerative", "skin", "lesions", "receiving", "immunosuppressive", "doses", "C0032950#ent", "<e1>", "and", "cyclosporine", "for", "the", "treatment", "of", "C0002878#ent", "<e2>"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [21, 22]}}
{"token": ["C0032950#ent", "<e1>", "reduced", "the", "C0002878#ent", "<e2>", "eosinophilia", ",", "lymph", "node", "swelling", "and", "splenomegaly", ",", "but", "NK", "activity", "remained", "low", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [4, 5]}}
{"token": ["Our", "results", "show", "a", "high", "degree", "of", "correlation", "of", "the", "C1848651#ent", "<e1>", "staining", "with", "C1366520#ent", "<e2>", ",", "lamp-1", ",", "and", "N-cadherin", "expressions", ",", "but", "not", "with", "epidermal", "growth", "factor", "receptor", "beta1-integrin", "expressions", "."], "h": {"id": "C1848651", "name": "C1848651#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366520", "name": "C1366520#ent", "pos": [14, 15]}}
{"token": ["Jejunal", "loops", "anaesthetized", "rats", "were", "filled", "with", "buffered", "isotonic", "solutions", "of", "tritiated", "water", "(", "C1705581#ent", "<e1>", ")", ",", "urea", ",", "antipyrine", "and", "C1742019#ent", "<e2>", "pH", "6", "-", "8", "."], "h": {"id": "C1705581", "name": "C1705581#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [22, 23]}}
{"token": ["In", "many", "countries", "of", "the", "Third", "World", "C0010678#ent", "<e1>", ",", "and", "especially", "C0338437#ent", "<e2>", ",", "is", "a", "widespread", "problem", "."], "h": {"id": "C0010678", "name": "C0010678#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0338437", "name": "C0338437#ent", "pos": [12, 13]}}
{"token": ["The", "C0034068#ent", "<e1>", "induced", "by", "isoproterenol", "was", "reduced", "at", "the", "stage", "of", "C0149721#ent", "<e2>", "which", "was", "followed", "by", "further", "reduction", "of", "C0034068#ent", "<e1>", "at", "CHF", "stage", "."], "h": {"id": "C0149721", "name": "C0149721#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0034068", "name": "C0034068#ent", "pos": [1, 2]}}
{"token": ["Co-ASS", "was", "an", "efficient", "COX-1", "inhibitor", "C1334349#ent", "<e1>", "inhibitory", "activity", "and", "auranofin", "inhibited", "both", "C1415652#ent", "<e2>", "and", "12-LOX", "eicosanoid", "production", "."], "h": {"id": "C1334349", "name": "C1334349#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [14, 15]}}
{"token": ["Foreign", "bodies", "air", "way", "common", "days", "occurrence", "in", "C3898066#ent", "<e1>", "widespread", "subcutaneous", "emphysema", "form", "scalp", "to", "C0236078#ent", "<e2>", "is", "a", "rare", "entity", "in", "foreign", "body", "bronchus"], "h": {"id": "C3898066", "name": "C3898066#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0236078", "name": "C0236078#ent", "pos": [16, 17]}}
{"token": ["The", "dexamethasone-mediated", "increase", "in", "C0017801#ent", "<e1>", "mRNA", "abundance", "is", "glucocorticoid", "receptor-mediated", ";", "C0701303#ent", "<e2>", "(", "a", "glucocorticoid", "receptor", "blocker", "completely", "blocked", "the", "effect", "of", "dexamethasone", "."], "h": {"id": "C0017801", "name": "C0017801#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0701303", "name": "C0701303#ent", "pos": [12, 13]}}
{"token": ["Electrophoretic", "mobility", "shift", "assays", "recombinant", "C1417840#ent", "<e1>", "and", "both", "C2987364#ent", "<e2>", "and", "mutant", "c-mos", "oligonucleotides", "the", "binding", "of", "C1417840#ent", "<e1>", "to", "an", "extended", "half", "site", "CCAAGTTCA", ",", "which", "overlaps", "the", "first", "hexamer", "of", "the", "COUP-TF", "binding", "site", "."], "h": {"id": "C1417840", "name": "C1417840#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}}
{"token": ["In", "each", "cell", "line", "C1414689#ent", "<e1>", "mRNA", "expression", "was", "unchanged", "but", "both", "alleles", "of", "the", "C3539658#ent", "<e2>", "a", "point", "mutation", "in", "highly", "conserved", "domains", "of", "the", "coding", "region"], "h": {"id": "C1414689", "name": "C1414689#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539658", "name": "C3539658#ent", "pos": [15, 16]}}
{"token": ["C0338465#ent", "<e1>", "a", "combination", "of", "C0017168#ent", "<e2>", "spastic", "torticollis", "dystonic", "body", "movements", "or", "without", "hiatal", "hernia"], "h": {"id": "C0338465", "name": "C0338465#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [5, 6]}}
{"token": ["C0338465#ent", "<e1>", "a", "dystonic", "movement", "disorder", "in", "children", "with", "severe", "C0017168#ent", "<e2>"], "h": {"id": "C0338465", "name": "C0338465#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [10, 11]}}
{"token": ["The", "mutations", "could", "affect", "the", "ability", "of", "C0694887#ent", "<e1>", "to", "bind", "C0672708#ent", "<e2>", "or", "perturb", "the", "intracellular", "interactions", "of", "C0694887#ent", "<e1>", "with", "other", "proteins", "involved", "in", "C0672708#ent", "<e2>", "signaling", "."], "h": {"id": "C0672708", "name": "C0672708#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0694887", "name": "C0694887#ent", "pos": [7, 8]}}
{"token": ["We", "show", "that", "in", "Kif3a-deficient", "mesenchymal", "tissues", "the", "repressor", "function", "Gli3", "transcription", "factor", "the", "activation", "of", "the", "C0672708#ent", "<e1>", "transcriptional", "targets", "C0694887#ent", "<e2>", "and", "Gli1", "are", "compromised", "."], "h": {"id": "C0672708", "name": "C0672708#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0694887", "name": "C0694887#ent", "pos": [21, 22]}}
{"token": ["In", "conclusion", ",", "oxidative", "stress", "increases", "the", "Glut1", "transcription", "rate", "by", "mechanisms", "that", "may", "involve", "activation", "of", "C0812312#ent", "<e1>", "binding", "to", "enhancer", "1", "the", "C1335837#ent", "<e2>"], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1335837", "name": "C1335837#ent", "pos": [24, 25]}}
{"token": ["Both", "activation", "of", "C0812312#ent", "<e1>", "binding", "and", "elevation", "of", "C1335837#ent", "<e2>", "mRNA", "were", "prevented", "by", "cycloheximide", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335837", "name": "C1335837#ent", "pos": [9, 10]}}
{"token": ["P.", "aeruginosa", "secretes", "various", "proteases", ",", "among", "them", ",", "C0699918#ent", "<e1>", "and", "protease", "IV", "been", "found", "to", "degrade", "C1420002#ent", "<e2>", "and", "SP-D", "and", "abrogate", "their", "immune", "function"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [18, 19]}}
{"token": ["C0027066#ent", "<e1>", "seemed", "to", "have", "a", "spinal", "origin", "showed", "no", "giant", "C1826261#ent", "<e2>", ",", "enhanced", "LLR", "or", "cortical", "spikes", "in", "the", "electrophysiological", "studies"], "h": {"id": "C0027066", "name": "C0027066#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826261", "name": "C1826261#ent", "pos": [11, 12]}}
{"token": ["As", "with", "lisuride", ",", "the", "severity", "of", "C0027066#ent", "<e1>", "reduced", "although", "the", "size", "of", "the", "C1826261#ent", "<e2>", "was", "increased", "."], "h": {"id": "C0027066", "name": "C0027066#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826261", "name": "C1826261#ent", "pos": [15, 16]}}
{"token": ["Only", "PC1", "but", "none", "of", "the", "other", "convertases", "tested", "including", "C1418600#ent", "<e1>", "were", "capable", "of", "generating", "C1335805#ent", "<e2>", "."], "h": {"id": "C1418600", "name": "C1418600#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335805", "name": "C1335805#ent", "pos": [16, 17]}}
{"token": ["Both", "PC1", "and", "C1418600#ent", "<e1>", "can", "cleave", "the", "C1335805#ent", "<e2>", "sites", "of", "pairs", "of", "basic", "amino", "acids", "yield", "intermediate-sized", "fragments", "."], "h": {"id": "C1418600", "name": "C1418600#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335805", "name": "C1335805#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "demonstrate", "that", "the", "prohormone", "convertases", "PC1", "and", "C1418600#ent", "<e1>", "are", "involved", "in", "proteolytic", "processing", "C1335805#ent", "<e2>"], "h": {"id": "C1418600", "name": "C1418600#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335805", "name": "C1335805#ent", "pos": [16, 17]}}
{"token": ["Unlike", "phenylbutazone", ",", "C0021246#ent", "<e1>", "and", "cortisone", ",", "C0070123#ent", "<e2>", "showed", "no", "ulcerogenous", "effect", "nor", "haemorrhage", "type", "alterations", "at", "gastroduodenal", "level", ",", "at", "least", "in", "the", "cases", "treated", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0070123", "name": "C0070123#ent", "pos": [8, 9]}}
{"token": ["Exposure", "levels", "associated", "with", "stem/base", "section", "of", "tank", "support", "OSHA", "'s", "policy", "requiring", "air", "monitoring", "work", "at", "levels", "below", "the", "criterion", "established", "by", "C1705819#ent", "<e1>", "in", "identifying", "C1416801#ent", "<e2>", "."], "h": {"id": "C1705819", "name": "C1705819#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1416801", "name": "C1416801#ent", "pos": [27, 28]}}
{"token": ["In", "the", "present", "study", ",", "we", "describe", "the", "effects", "of", "medium", "composition", "in", "primary", "cultures", "rat", "hepatocytes", "on", "the", "expression", "of", "two", "major", "constituent", "female-dependent", "C0010762#ent", "<e1>", "isoforms", ",", "CYP2C12", "and", "C1413867#ent", "<e2>", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1413867", "name": "C1413867#ent", "pos": [31, 32]}}
{"token": ["Postoperative", "serum", "hyperamylasemia", ",", "whether", "primarily", "renal", "or", "C0030304#ent", "<e1>", ",", "can", "not", "be", "decreased", "by", "pretreatment", "with", "C0002144#ent", "<e2>", ",", "vitamin", "C", "and", "vitamin", "E."], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002144", "name": "C0002144#ent", "pos": [18, 19]}}
{"token": ["To", "compare", "the", "inhibitory", "potential", "of", "the", "HIV", "protease", "saquinavir", ",", "ritonavir", "and", "C0700483#ent", "<e1>", "against", "CYP1A2", ",", "CYP2C9", ",", "CYP2E1", "and", "C1142644#ent", "<e2>", "catalysed", "metabolic", "reactions", "human", "liver", "microsomes", "in", "vitro"], "h": {"id": "C0700483", "name": "C0700483#ent", "pos": [13, 14]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [22, 23]}}
{"token": ["At", "this", "concentration", ",", "C0700483#ent", "<e1>", "completely", "inhibited", "the", "formation", "of", "3-methoxymorphinan", "by", "C1142644#ent", "<e2>", "and", "rCYP3A5", "."], "h": {"id": "C0700483", "name": "C0700483#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [13, 14]}}
{"token": ["Conversion", "from", "C0209368#ent", "<e1>", "MMF", ",", "CellCept", ")", "to", "enteric-coated", "mycophenolate", "sodium", "EC-MPS", ",", "C1620923#ent", "<e2>", ")", "is", "safe", "and", "effective", "in", "renal", "transplant", "patients", "treated", "with", "standard", "dose", "2", "g", "MMF", "."], "h": {"id": "C0209368", "name": "C0209368#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1620923", "name": "C1620923#ent", "pos": [14, 15]}}
{"token": ["Of", "12", "patients", "with", "inflammatory", "bowel", "disease", "C0022104#ent", "<e1>", ")", "and", "ankylosing", "spondylitis", "AS", ")", "or", "sacroiliitis", "(", "C1420066#ent", "<e2>", ")", ",", "only", "4", "(", "32", "%", ")", "had", "HLA-B27", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [18, 19]}}
{"token": ["A", "marked", "increase", "of", "C1366488#ent", "<e1>", "also", "produced", "by", "a", "10-min", "pulse", "of", "the", "C0872245#ent", "<e2>", "10", "mM", ")", "included", "in", "the", "perfusate", "."], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0872245", "name": "C0872245#ent", "pos": [14, 15]}}
{"token": ["Deficiency", "of", "this", "enzyme", "is", "associated", "with", "C2931835#ent", "<e1>", "HPII", ")", ",", "an", "autosomal", "recessive", "disorder", "by", "accumulation", "of", "C0044620#ent", "<e2>", "P5C", ")", "and", "proline", "."], "h": {"id": "C2931835", "name": "C2931835#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0044620", "name": "C0044620#ent", "pos": [19, 20]}}
{"token": ["Two", "patients", "presented", "with", "long-standing", "chronic", "bronchitis", "C0231807#ent", "<e1>", "5", "and", "3", "months", "'", "C0720099#ent", "<e2>", ",", "respectively", ",", "and", "had", "interlobular", "septal", "fibrosis", "on", "chest", "high", "resolution", "CT", "."], "h": {"id": "C0231807", "name": "C0231807#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [14, 15]}}
{"token": ["A", "66-year-old", "woman", "was", "admitted", "to", "our", "hospital", "because", "of", "C0231807#ent", "<e1>", "chronic", "cough", "three", "months", "'", "C0720099#ent", "<e2>", "."], "h": {"id": "C0231807", "name": "C0231807#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [17, 18]}}
{"token": ["Mutations", "in", "the", "WFS1", "gene", "beta-cell", "death", ",", "resulting", "in", "a", "monogenic", "form", "of", "C0011849#ent", "<e1>", "known", "as", "C1858028#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C1858028", "name": "C1858028#ent", "pos": [18, 19]}}
{"token": ["Therefore", ",", "we", "investigated", "the", "diagnostic", "value", "two", "novel", "monoclonal", "antibodies", "C3539751#ent", "<e1>", "1", "against", "Ki-67", "and", "C3810569#ent", "<e2>", "10", "against", "PCNA", ")", "in", "the", "detection", "of", "dysplasia", "."], "h": {"id": "C3539751", "name": "C3539751#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [17, 18]}}
{"token": ["Retroviral", "reverse", "transcriptases", "C1433276#ent", "<e1>", ")", "have", "both", "DNA", "polymerase", "C0085431#ent", "<e2>", "RNase", "H", "activities", "."], "h": {"id": "C1433276", "name": "C1433276#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085431", "name": "C0085431#ent", "pos": [10, 11]}}
{"token": ["White", "potato", "tuber", "tissue", "reacts", "upon", "wounding", "with", "a", "rapid", "increase", "in", "activity", "of", "both", "C0035379#ent", "<e1>", "II", "as", "well", "as", "C0031727#ent", "<e2>"], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [15, 16]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["C1859194#ent", "<e1>", "an", "autosomal", "recessive", "disorder", "by", "C0162835#ent", "<e2>", "occurrence", "of", "acute", "phases", "hemophagocytosis", "."], "h": {"id": "C1859194", "name": "C1859194#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0162835", "name": "C0162835#ent", "pos": [7, 8]}}
{"token": ["In", "the", "radiographic", "findings", ",", "the", "patients", "of", "the", "M.", "tuberculosis", "group", "presented", "multiple", "hilar", "and", "C0520743#ent", "<e1>", "miliary", "shadow", ",", "and", "C0747690#ent", "<e2>"], "h": {"id": "C0520743", "name": "C0520743#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0747690", "name": "C0747690#ent", "pos": [22, 23]}}
{"token": ["The", "increase", "in", "neuronal", "activity", "by", "iontophoretically", "applied", "C3273437#ent", "<e1>", "was", "nearly", "abolished", "by", "C0099122#ent", "<e2>", "but", "not", "by", "AP-5", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0099122", "name": "C0099122#ent", "pos": [14, 15]}}
{"token": ["As", "a", "functional", "test", "androgen", "dependence", "hpg", "mice", "were", "treated", "for", "70", "days", "with", "estradiol", "plus", "C0591237#ent", "<e1>", "(", "bicalutamide", ")", ",", "an", "C2936804#ent", "<e2>"], "h": {"id": "C0591237", "name": "C0591237#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2936804", "name": "C2936804#ent", "pos": [23, 24]}}
{"token": ["Of", "the", "three", "patients", "without", "C1535939#ent", "<e1>", "one", "patient", "with", "C0264511#ent", "<e2>", "Branhamella", "catarrhalis", "infection", "have", "failed", "to", "respond", "to", "empirical", "treatment"], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0264511", "name": "C0264511#ent", "pos": [10, 11]}}
{"token": ["It", "was", "evident", "from", "the", "isobolographic", "plot", "that", "the", "interactions", "between", "ethanol", "and", "C0700349#ent", "<e1>", "and", "ethanol", "and", "C0008188#ent", "<e2>", "were", "more", "than", "additive", "."], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [18, 19]}}
{"token": ["Interaction", "between", "ethanol", "and", "C0700349#ent", "<e1>", "was", "greater", "than", "that", "between", "ethanol", "and", "C0008188#ent", "<e2>", "."], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [13, 14]}}
{"token": ["C0700349#ent", "<e1>", ",", "meprobamate", ",", "diazepam", "and", "C0008188#ent", "<e2>", "could", "depress", "the", "M-wave", "without", "depressing", "behavior"], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [7, 8]}}
{"token": ["Tropical", "diseases", "present", "as", "a", "skin", "disease", "such", ",", "or", "a", "generalised", "disease", "C0037274#ent", "<e1>", "the", "commonest", "signs", "being", "ulcers", ",", "papules", ",", "C0015230#ent", "<e2>", ",", "changes", "in", "pigmentation", ",", "and", "itching", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [23, 24]}}
{"token": ["In", "clinical", "trials", "morning", "administration", "C2718951#ent", "<e1>", "either", "as", "monotherapy", "or", "adjunctive", "therapy", "C3536898#ent", "<e2>", "or", "insulin", "reduces", "HbA1c", "levels", "relative", "to", "placebo", "by", "0.55", "-", "1.2", "."], "h": {"id": "C2718951", "name": "C2718951#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536898", "name": "C3536898#ent", "pos": [13, 14]}}
{"token": ["The", "time", "course", "appearance", "of", "labelled", "products", "suggested", "that", "monoacylglycerol", "could", "be", "released", "as", "a", "result", "of", "the", "action", "of", "phospholipase", "A1", "by", "C1744635#ent", "<e1>", "by", "the", "initial", "action", "of", "phospholipase", "C", "by", "C1442515#ent", "<e2>"], "h": {"id": "C1744635", "name": "C1744635#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1442515", "name": "C1442515#ent", "pos": [33, 34]}}
{"token": ["The", "ACTH", "and", "cortisol", "responses", "C1366488#ent", "<e1>", "administration", "were", "studied", "in", "21", "patients", "with", "C0001623#ent", "<e2>", "compared", "with", "those", "obtained", "in", "15", "control", "subjects"], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001623", "name": "C0001623#ent", "pos": [14, 15]}}
{"token": ["First", ",", "the", "amount", "of", "diSia", "epitope", "C0072522#ent", "<e1>", "increased", "during", "retinoic", "C1539598#ent", "<e2>", "neurite", "formation", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539598", "name": "C1539598#ent", "pos": [12, 13]}}
{"token": ["However", ",", "compared", "with", "corpus", "cavernosum", "PDE5", ",", "the", "C0014442#ent", "<e1>", "higher", "sensitivity", "to", "C0012582#ent", "<e2>", "and", "IBMX", "(", "IC50", "0.46", "and", "1.8", "uM", ",", "respectively", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012582", "name": "C0012582#ent", "pos": [14, 15]}}
{"token": ["There", "are", "limited", "studies", "of", "stent", "thrombosis", "the", "modern", "era", "C0242905#ent", "<e1>", "high-pressure", "deployment", ",", "and", "current", "C0016018#ent", "<e2>"], "h": {"id": "C0242905", "name": "C0242905#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [17, 18]}}
{"token": ["On", "the", "basis", "of", "hemagglutinin", "mobility", "on", "sodium", "dodecyl", "sulfate", "gels", "its", "sensitivity", "to", "C0014175#ent", "<e1>", "it", "was", "evident", "that", "C0028247#ent", "<e2>", "and", "taxol", "arrested", "hemagglutinin", "at", "different", "intracellular", "sites", "."], "h": {"id": "C0014175", "name": "C0014175#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0028247", "name": "C0028247#ent", "pos": [20, 21]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "investigate", "whether", "selective", "respiratory", "muscle", "training", "could", "alleviate", "C0013404#ent", "<e1>", "and", "improve", "exercise", "performance", "in", "patients", "with", "C0264722#ent", "<e2>"], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0264722", "name": "C0264722#ent", "pos": [24, 25]}}
{"token": ["The", "tissue", "samples", "brain", ",", "gills", ",", "heart", ",", "liver", ",", "skeletal", "muscle", "kidney", ")", "were", "collected", "and", "the", "expression", "of", "C1420873#ent", "<e1>", ",", "ADAL", "and", "ADA2", "C1417679#ent", "<e2>", "was", "characterized", "."], "h": {"id": "C1420873", "name": "C1420873#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [27, 28]}}
{"token": ["The", "action", "of", "the", "C0072402#ent", "<e1>", "EC", "3.4.21", "-", "-)of", "human", "neutrophil", "leucocytes", "elastase", "and", "C0054868#ent", "<e2>", "on", "cartilage", "and", "tendon", "was", "investigated", "."], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054868", "name": "C0054868#ent", "pos": [15, 16]}}
{"token": ["The", "oxidative", "metabolism", "the", "C0000970#ent", "<e1>", "amodiaquine", ",", "and", "C0009079#ent", "<e2>", "is", "simulated", "in", "an", "electrochemical", "(", "EC", ")", "flow-through", "cell", ",", "which", "is", "coupled", "online", "to", "an", "LC/MS", "system", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [9, 10]}}
{"token": ["An", "amino-terminal", "coiled", "coil", "domain", "C3273653#ent", "<e1>", "is", "responsible", "for", "mediating", "oligomerization", "of", "the", "C1420703#ent", "<e2>", "resulting", "in", "constitutive", "activation", "of", "the", "TRK", "protein", "tyrosine", "kinase", "oncogenesis", "."], "h": {"id": "C3273653", "name": "C3273653#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420703", "name": "C1420703#ent", "pos": [14, 15]}}
{"token": ["Phospholipase", "A2", "PLA2", ";", "phosphatide", "2-acylhydrolase", "C0757021#ent", "<e1>", "activity", "from", "human", "platelets", "increases", "significantly", "when", "the", "C0014442#ent", "<e2>", "is", "separated", "from", "an", "endogenous", "inhibitor(s", ")", "."], "h": {"id": "C0757021", "name": "C0757021#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["Complementary", "DNA", "the", "alpha", "and", "the", "C0599220#ent", "<e1>", "recently", "been", "isolated", ",", "but", "expression", "of", "C1414549#ent", "<e2>", "by", "transfected", "cells", "has", "not", "yet", "been", "achieved", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414549", "name": "C1414549#ent", "pos": [15, 16]}}
{"token": ["As", "a", "result", "of", "the", "high", "resolution", "of", "two-dimensional", "gel", "electrophoresis", "nine", "C0599220#ent", "<e1>", "of", "LMW", "glutenins", "were", "identified", "as", "the", "most", "predominant", "C1414549#ent", "<e2>"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414549", "name": "C1414549#ent", "pos": [23, 24]}}
{"token": ["Culturing", ",", "particularly", "in", "the", "presence", "of", "C2697656#ent", "<e1>", ",", "markedly", "increased", "the", "proportion", "of", "C0661256#ent", "<e2>", "neurons", ";", "NOS-immunoreactive", "neurons", "were", "unchanged", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0661256", "name": "C0661256#ent", "pos": [15, 16]}}
{"token": ["Similar", "to", "C0000503#ent", "<e1>", ",", "the", "GABA(B", ")", "agonist", "C0004609#ent", "<e2>", "(", "10", "and", "20", "mg/kg", ",", "i.p", ".", ")"], "h": {"id": "C0000503", "name": "C0000503#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004609", "name": "C0004609#ent", "pos": [9, 10]}}
{"token": ["Some", "of", "the", "effect", "of", "C0000503#ent", "<e1>", "could", "be", "reproduced", "by", "C0004609#ent", "<e2>", "and", "reduced", "by", "the", "GABAB", "antagonist", "CGP", "35348", "."], "h": {"id": "C0000503", "name": "C0000503#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004609", "name": "C0004609#ent", "pos": [11, 12]}}
{"token": ["It", "has", "been", "suggested", "by", "several", "authors", "that", "the", "prevalence", "of", "mitral", "valve", "prolapse", "C1866956#ent", "<e1>", "increased", "in", "individuals", "with", "the", "C0016667#ent", "<e2>"], "h": {"id": "C1866956", "name": "C1866956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0016667", "name": "C0016667#ent", "pos": [21, 22]}}
{"token": ["To", "determine", "whether", "azithromycin", ",", "250", "mg/d", ",", "is", "effective", "prophylaxis", "for", "C0009450#ent", "<e1>", "for", "both", "C0023899#ent", "<e2>", "and", "subsequent", "blood", "infection", "Plasmodium", "falciparum"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["Viral", "hepatitis", "the", "most", "common", "serious", "C0009450#ent", "<e1>", "by", "viruses", "that", "attack", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [13, 14]}}
{"token": ["In", "the", "early", "state", "C1719788#ent", "<e1>", ",", "none", "of", "22", "C0524891#ent", "<e2>", "transcripts", "seemed", "to", "be", "dominant", "by", "reverse", "transcription-polymerase", "chain", "reaction", "analysis", "total", "RNA", "and", "flow", "cytometric", "analysis"], "h": {"id": "C1719788", "name": "C1719788#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0524891", "name": "C0524891#ent", "pos": [10, 11]}}
{"token": ["Our", "present", "data", "support", "that", "C1417832#ent", "<e1>", "directly", "stimulates", "C3813124#ent", "<e2>", "and", "pulmonary", "epithelial", "cells", "produce", "IL-8", "."], "h": {"id": "C1417832", "name": "C1417832#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [9, 10]}}
{"token": ["This", "peak", "moved", "to", "the", "G2/M-phase", "position", "at", "11", "h", "after", "the", "removal", "of", "C2827378#ent", "<e1>", "or", "at", "14", "h", "after", "the", "removal", "of", "C1271552#ent", "<e2>", "or", "doxorubicin", "."], "h": {"id": "C2827378", "name": "C2827378#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1271552", "name": "C1271552#ent", "pos": [24, 25]}}
{"token": ["C0000608#ent", "<e1>", "and", "also", "by", "desalting", "serum", "and", "adding", "MgCl2", "and", "C1414518#ent", "<e2>", "."], "h": {"id": "C0000608", "name": "C0000608#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414518", "name": "C1414518#ent", "pos": [11, 12]}}
{"token": ["The", "production", "of", "ACT", "and", "PI", "was", "increased", "by", "C1366463#ent", "<e1>", ",", "decreased", "by", "C1415066#ent", "<e2>", "gamma", "and", "unaffected", "by", "dex", "."], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415066", "name": "C1415066#ent", "pos": [14, 15]}}
{"token": ["We", "further", "show", "that", "C3889382#ent", "<e1>", "is", "required", "for", "Salmonella", "virulence", "mice", ",", "in", "contrast", "to", "C0254269#ent", "<e2>", "flavorubredoxin", ",", "or", "cytochrome", "c", "nitrite", "reductase"], "h": {"id": "C3889382", "name": "C3889382#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0254269", "name": "C0254269#ent", "pos": [16, 17]}}
{"token": ["Other", "new", "drugs", "being", "tested", "include", "C1765315#ent", "<e1>", ",", "an", "oral", "serine", "threonine", "kinase", "inhibitor", "vinflunine", ",", "a", "vinca", "alkaloid", "dihydrofolate", "reductase", "inhibitors", "and", "C1373008#ent", "<e2>"], "h": {"id": "C1765315", "name": "C1765315#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1373008", "name": "C1373008#ent", "pos": [24, 25]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "efficacy", "of", "C0038633#ent", "<e1>", "in", "the", "treatment", "of", "C0014868#ent", "<e2>", "children", "."], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0014868", "name": "C0014868#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "C0038633#ent", "<e1>", "is", "useful", "in", "the", "management", "of", "C0014868#ent", "<e2>"], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0014868", "name": "C0014868#ent", "pos": [11, 12]}}
{"token": ["C0038633#ent", "<e1>", "is", "a", "useful", "drug", "for", "the", "treatment", "of", "C0014868#ent", "<e2>", "children", "."], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014868", "name": "C0014868#ent", "pos": [10, 11]}}
{"token": ["The", "similarities", "include", "the", "effects", "of", "antagonists", "(", "soluble", "beta-glucan", "and", "C0064631#ent", "<e1>", ")", "and", "of", "inhibitors", "of", "Src", "family", "kinases", "the", "Tec", "kinase", "Btk", "C2936824#ent", "<e2>", "the", "Map", "kinases", "ERK", "and", "p38", "."], "h": {"id": "C0064631", "name": "C0064631#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [25, 26]}}
{"token": ["This", "article", "reviews", "four", "types", "of", "C0017658#ent", "<e1>", "that", "occur", "in", "childhood", ":", "C0156221#ent", "<e2>", "IgA", "nephropathy", "Alport's", "syndrome", "and", "membranoproliferative", "glomerulonephritis"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [13, 14]}}
{"token": ["Nucleotides", "are", "rapidly", "converted", "to", "adenosine", "by", "a", "family", "of", "C2932861#ent", "<e1>", "including", "CD39", "and", "C1417861#ent", "<e2>", "."], "h": {"id": "C2932861", "name": "C2932861#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417861", "name": "C1417861#ent", "pos": [15, 16]}}
{"token": ["C0019360#ent", "<e1>", "be", "considered", "in", "patients", "presenting", "with", "an", "C0005697#ent", "<e2>", "obscure", "cause", "."], "h": {"id": "C0019360", "name": "C0019360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [9, 10]}}
{"token": ["It", "is", "a", "rare", "idiosyncratic", "reaction", "major", "tranquilizers", ",", "including", "the", "phenothiazines", ",", "C0006525#ent", "<e1>", ",", "and", "thioxanthenes", ";", "haloperidol", "and", "C0016368#ent", "<e2>", "fluphenazine", "decanoate", "the", "drugs", "most", "commonly", "incriminated", "."], "h": {"id": "C0006525", "name": "C0006525#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [21, 22]}}
{"token": ["The", "most", "effective", "agents", "in", "this", "respect", "were", "those", "shown", "by", "other", "workers", "to", "have", "a", "selective", "action", "at", "dopamine", "receptors", "notably", "the", "C0006525#ent", "<e1>", ",", "thioxanthines", "and", "C0016368#ent", "<e2>", "."], "h": {"id": "C0006525", "name": "C0006525#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [28, 29]}}
{"token": ["Furthermore", ",", "nuclear", "accumulation", "C1453853#ent", "<e1>", "following", "tumor", "necrosis", "factor", "treatment", "is", "unaffected", "by", "the", "loss", "of", "C4283740#ent", "<e2>", "."], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [17, 18]}}
{"token": ["Primary", "neoplasms", "the", "pancreas", "and", "tumors", "metastatic", "to", "the", "pancreas", "are", "capable", "of", "initiating", "an", "epidode", "of", "C0030305#ent", "<e1>", "severe", "enough", "to", "cause", "the", "development", "of", "a", "C0030299#ent", "<e2>", "ascites", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030299", "name": "C0030299#ent", "pos": [27, 28]}}
{"token": ["In", "view", "of", "the", "pathological", "laboratory", "tests", "which", "suggested", "C0030305#ent", "<e1>", "the", "visualized", "cystic", "abdominal", "mass", "regarded", "as", "a", "C0030299#ent", "<e2>"], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030299", "name": "C0030299#ent", "pos": [19, 20]}}
{"token": ["We", "report", "a", "case", "of", "severe", "C0030305#ent", "<e1>", "of", "biliary", "etiology", "complicated", "with", "a", "C0030299#ent", "<e2>", "colonic", "stenosis", "localized", "in", "the", "sigmoid", ",", "that", "we", "interpret", "as", "secondary", "to", "lesion", "produced", "by", "pancreatic", "enzymes", "spread"], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030299", "name": "C0030299#ent", "pos": [14, 15]}}
{"token": ["Multiple", "soluble", "factors", "may", "contribute", "to", "this", "antiviral", "activity", "including", "neutralizing", "antibodies", "secretory", "leukocyte", "protease", "inhibitor", "SLPI", ")", ",", "C0030956#ent", "<e1>", "as", "defensins", "and", "C0010646#ent", "<e2>", ",", "glycoproteins", "including", "thrombospondin", "and", "lactoferrin", ",", "and", "complement", "components"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010646", "name": "C0010646#ent", "pos": [24, 25]}}
{"token": ["C1413972#ent", "<e1>", "reduced", "the", "association", "of", "C1421567#ent", "<e2>", "with", "TCR-zeta", "and", "interfered", "with", "C1421567#ent", "<e2>", "but", "not", "Lck", "signaling", "."], "h": {"id": "C1413972", "name": "C1413972#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421567", "name": "C1421567#ent", "pos": [6, 7]}}
{"token": ["We", "have", "screened", "35", "late-stage", "bladder", "tumors", "mutations", "in", "PTEN", "and", "MXI1", ",", "both", "C1417679#ent", "<e1>", "mapping", "to", "C0795839#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0795839", "name": "C0795839#ent", "pos": [18, 19]}}
{"token": ["Aneurysm", "of", "the", "abdominal", "aorta", "C1364818#ent", "<e1>", ")", "is", "multifactorial", "disease", "related", "to", "acquired", "factors", "C0027719#ent", "<e2>", ")", "and", "genetic", "factors", "collagen", "anomalies", "with", ",", "in", "some", "cases", ",", "a", "familial", "component"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027719", "name": "C0027719#ent", "pos": [15, 16]}}
{"token": ["Several", "recent", "studies", "have", "asked", "whether", "apolipoprotein", "E", "apoE", "for", "the", "protein", ",", "APOE", "for", "the", "gene", ")", "influences", "these", "aspects", "of", "specific", "C0027868#ent", "<e1>", "as", "it", "does", "in", "central", "nervous", "system", "disorders", "as", "C2931257#ent", "<e2>"], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2931257", "name": "C2931257#ent", "pos": [34, 35]}}
{"token": ["Patients", "with", "Henoch-Sch\u00f6nlein", "purpura", "present", "with", "a", "C0221201#ent", "<e1>", "the", "scrotum", ",", "lack", "a", "C0015230#ent", "<e2>", "elsewhere", ",", "and", "have", "no", "arthritis", "or", "hematuria", "are", "likely", "to", "be", "explored", "."], "h": {"id": "C0221201", "name": "C0221201#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [14, 15]}}
{"token": ["C1422386#ent", "<e1>", "and", "INI1/hSNF5/BAF47", "functioned", "together", "to", "suppress", "C0087140#ent", "<e2>"], "h": {"id": "C1422386", "name": "C1422386#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [8, 9]}}
{"token": ["Compact", "expression", "domains", "of", "orthologues", "of", "known", "nematogenesis-associated", "genes", "Piwi", ",", "dickkopf-3", ",", "C0009325#ent", "<e1>", "and", "NOWA", ")", "were", "correspondingly", "staggered", "along", "the", "C3540638#ent", "<e2>", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540638", "name": "C3540638#ent", "pos": [23, 24]}}
{"token": ["While", "most", "C0270898#ent", "<e1>", "patients", "recover", "C1824218#ent", "<e2>", "and", "hand", "function", "the", "residual", "nerve", "weakness", "to", "muscle", "imbalances", "about", "the", "shoulder", "which", "may", "cause", "bony", "deformities"], "h": {"id": "C0270898", "name": "C0270898#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1824218", "name": "C1824218#ent", "pos": [6, 7]}}
{"token": ["In", "kidneys", ",", "stimulation", "of", "C0001492#ent", "<e1>", "egress", "of", "cAMP", ",", "conversion", "of", "cAMP", "to", "C4084937#ent", "<e2>", "by", "ecto-phosphodiesterase", ",", "and", "metabolism", "of", "C4084937#ent", "<e2>", "to", "adenosine", "by", "ecto-5'-nucleotidase", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4084937", "name": "C4084937#ent", "pos": [15, 16]}}
{"token": ["This", "C0038354#ent", "<e1>", ",", "in", "contrast", "to", "C0030920#ent", "<e2>", "is", "responsive", "to", "prostaglandins", "and", "other", "cytoprotective", "agents"], "h": {"id": "C0038354", "name": "C0038354#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", ",", "recombinant", "C0304925#ent", "<e1>", "evaluated", "for", "its", "growth-promoting", "activity", "two", "cell", "lines", "C1538486#ent", "<e2>", "and", "SCC-9", "."], "h": {"id": "C0304925", "name": "C0304925#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1538486", "name": "C1538486#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "we", "administered", "C1098320#ent", "<e1>", ",", "an", "AT1", "blocker", ",", "to", "suppress", "redundant", "AT1", "signaling", "C3203102#ent", "<e2>", "mice", "and", "evaluated", "the", "efficacy", "of", "this", "treatment", "in", "cardiac", "remodeling"], "h": {"id": "C1098320", "name": "C1098320#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3203102", "name": "C3203102#ent", "pos": [19, 20]}}
{"token": ["Presently", ",", "kidney", "transplantation", "the", "only", "treatment", "that", "may", "restore", "plasma", "C1414863#ent", "<e1>", "level", "and", "GSH-Px", "activity", "in", "patients", "suffering", "from", "end-stage", "C1561643#ent", "<e2>", "."], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [22, 23]}}
{"token": ["C1414863#ent", "<e1>", "content", "from", "64", "samples", "from", "subjects", "with", "C1561643#ent", "<e2>", "54", "from", "subjects", "suffering", "from", "several", "malignancies", "are", "determined", "and", "the", "results", "are", "compared", "to", "the", "reference", "values"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [9, 10]}}
{"token": ["Recently", ",", "we", "have", "shown", "that", "LPS", "inhibits", "both", "spontaneous", "and", "C0011609#ent", "<e1>", "mature", "B", "lymphocytes", "through", "cytosolic", "retention", "C0812198#ent", "<e2>", ",", "a", "proapoptotic", "protein", "the", "Bcl-2", "family", "by", "preventing", "its", "translocation", "to", "mitochondria", "."], "h": {"id": "C0011609", "name": "C0011609#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [19, 20]}}
{"token": ["The", "results", "demonstrated", "the", "pivotal", "role", "of", "apoptotic", "mechanism", "in", "the", "cytotoxic", "effect", "by", "daunorubicin", ",", "and", "confirmed", "the", "relationship", "between", "the", "C0011609#ent", "<e1>", "overexpression", "of", "C0812198#ent", "<e2>"], "h": {"id": "C0011609", "name": "C0011609#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [26, 27]}}
{"token": ["The", "C0031727#ent", "<e1>", "and", "transcriptional", "co-activation", "modes", "of", "C3889383#ent", "<e2>", "are", "both", "regulated", "by", "the", "cellular", "ATP/AMP", "ratio", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3889383", "name": "C3889383#ent", "pos": [8, 9]}}
{"token": ["All", "Burkitt", "lymphomas", "C0005859#ent", "<e1>", ")", "carry", "reciprocal", "chromosomal", "translocations", "activate", "the", "c-myc", "C0029016#ent", "<e2>", "through", "juxtaposition", "to", "one", "of", "the", "immunoglobulin", "(Ig)", "loci"], "h": {"id": "C0005859", "name": "C0005859#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [13, 14]}}
{"token": ["Similarly", ",", "the", "high", "incidence", "of", "cancer", "in", "C0005859#ent", "<e1>", "be", "caused", "by", "mitotic", "crossing-over", "to", "homozygosity", "or", "amplification", "of", "C0029016#ent", "<e2>", "."], "h": {"id": "C0005859", "name": "C0005859#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [20, 21]}}
{"token": ["The", "development", "of", "chromosomal", "abnormalities", "C1413800#ent", "<e1>", ")", "in", "the", "Philadelphia", "chromosome", "metaphases", "during", "C0935989#ent", "<e2>", "(", "IM", ")", "therapy", "in", "patients", "with", "newly", "diagnosed", "chronic", "myecloid", "leukemia", "CML", ")", "has", "been", "reported", "only", "anecdotally", "."], "h": {"id": "C1413800", "name": "C1413800#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0935989", "name": "C0935989#ent", "pos": [14, 15]}}
{"token": ["In", "the", "case", "of", "C0267662#ent", "<e1>", "the", "subject", "had", "secondary", "lactose", "intolerance", "dehydration", ",", "C0020625#ent", "<e2>", ",", "hypokalemia", ",", "hypochloremia", ",", "hyperreninemia", "and", "metabolic", "alkalosis"], "h": {"id": "C0267662", "name": "C0267662#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [14, 15]}}
{"token": ["We", "report", "here", "a", "protein-protein", "interaction", "C1705516#ent", "<e1>", "and", "NOSIP", "(", "C1425195#ent", "<e2>", "in", "rat", "brain", "in", "vivo"], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1425195", "name": "C1425195#ent", "pos": [11, 12]}}
{"token": ["Inhibition", "of", "PI-3", "kinase", "activity", "blocked", "the", "activation", "of", "C0299856#ent", "<e1>", "also", "blocked", "cell", "migration", "response", "to", "C1455836#ent", "<e2>", "."], "h": {"id": "C0299856", "name": "C0299856#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1455836", "name": "C1455836#ent", "pos": [17, 18]}}
{"token": ["As", "the", "menu", "of", "available", "antiretroviral", "agents", "to", "expand", ",", "C0939237#ent", "<e1>", "remains", "a", "proven", "and", "effective", "C1254351#ent", "<e2>", "for", "the", "treatment", "of", "HIV", "infection"], "h": {"id": "C0939237", "name": "C0939237#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [17, 18]}}
{"token": ["The", "present", "study", "was", "therefore", "designed", "to", "examine", "the", "effect", "of", "C0010592#ent", "<e1>", "A", "on", "cellular", "calcium", "content", "and", "on", "membrane", "C1422342#ent", "<e2>", "mechanisms", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422342", "name": "C1422342#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "we", "infer", "that", "increasing", "age", "is", "accompanied", "by", "greater", "disorderliness", "of", "somatostatin-withdrawn", "C1333674#ent", "<e1>", ",", "and", "hence", "rebound", "C3539616#ent", "<e2>", ",", "release", "."], "h": {"id": "C1333674", "name": "C1333674#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [20, 21]}}
{"token": ["The", "translocation", "produces", "an", "invariant", "chimaeric", "C3274736#ent", "<e1>", "transcript", "containing", "the", "amino", "terminal", "half", "NUP98", "fused", "in", "frame", "to", "C1333922#ent", "<e2>", "."], "h": {"id": "C3274736", "name": "C3274736#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333922", "name": "C1333922#ent", "pos": [19, 20]}}
{"token": ["Despite", "the", "low", "numbers", "of", "C1705610#ent", "<e1>", "expressed", "by", "post-confluent", "cells", ",", "filter-grown", "BMEC", "C0872351#ent", "<e2>", "were", "used", "to", "measure", "transcytosis", "of", "Tf", "."], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [14, 15]}}
{"token": ["In", "addition", "to", "the", "public", "datasets", ",", "Compagen", "also", "provides", "processed", "data", "like", "C3539540#ent", "<e1>", "assembled", "ESTs", "or", "predicted", "C0030956#ent", "<e2>", "."], "h": {"id": "C3539540", "name": "C3539540#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}}
{"token": ["We", "studied", "at", "autopsy", "a", "distinctive", "C0006272#ent", "<e1>", "three", "persons", "with", "C0264444#ent", "<e2>", "and", "hilar", "node", "fibrosis", "."], "h": {"id": "C0006272", "name": "C0006272#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0264444", "name": "C0264444#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "both", "enzymes", "responded", "identically", "to", "C0010980#ent", "<e1>", "and", "aminobenzoic", "acid", "hydrazide", "known", "inhibitors", "of", "C0027021#ent", "<e2>", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [16, 17]}}
{"token": ["5-Aminosalicylic", "acid", "4-ASA", ",", "and", "C0010980#ent", "<e1>", "demonstrated", "a", "powerful", "inhibitory", "effect", "on", "the", "catalytic", "activity", "C0027021#ent", "<e2>", ",", "whereas", "all", "drugs", "were", "equally", "effective", "in", "scavenging", "HOCl", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [16, 17]}}
{"token": ["The", "onset", "of", "C0037090#ent", "<e1>", "gradual", "and", "systemic", "complaints", "as", "headache", ",", "C0231218#ent", "<e2>", ",", "arthalgias", ",", "and", "low-grade", "fever", "are", "frequently", "prominent", "."], "h": {"id": "C0037090", "name": "C0037090#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [12, 13]}}
{"token": ["After", "70", "min", "preperfusion", ",", "electrical", "field", "stimulation", "a", "rapid", "increase", "in", "the", "amount", "of", "C2744579#ent", "<e1>", "in", "the", "effluent", "and", "the", "release", "of", "C1366535#ent", "<e2>", "and", "oxytocin", "also", "increased", "stimulation-dependently", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [24, 25]}}
{"token": ["These", "results", "suggest", "that", "C2744579#ent", "<e1>", "injected", "into", "the", "SON", "has", "antidiuretic", "effects", "to", "release", "of", "C1366535#ent", "<e2>", "through", "an", "activation", "of", "theophylline-sensitive", "purinoceptors", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [16, 17]}}
{"token": ["Using", "an", "immunoaffinity", "column", "comprised", "of", "immobilized", "monoclonal", "antibodies", "C1824669#ent", "<e1>", ",", "serum", "levels", "soluble", "C1824669#ent", "<e1>", "were", "found", "to", "be", "significantly", "elevated", "in", "C0026769#ent", "<e1>", "patients", "compared", "with", "healthy", "and", "other", "neurological", "disease", "controls", "."], "h": {"id": "C1824669", "name": "C1824669#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [24, 25]}}
{"token": ["This", "review", "will", "summarize", "the", "data", "on", "C1824669#ent", "<e1>", "and", "T", "cells", "and", "how", "C1824669#ent", "<e1>", "is", "likely", "involved", "in", "C0026769#ent", "<e1>"], "h": {"id": "C1824669", "name": "C1824669#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [20, 21]}}
{"token": ["The", "31-amino", "acid", "proteolipid", ",", "C1420247#ent", "<e1>", "(", "SLN", ")", ",", "is", "associated", "with", "fast-twitch", "skeletal", "muscle", "sarcoplasmic", "reticulum", "Ca2+-ATPase", "C1706178#ent", "<e2>", ")", "."], "h": {"id": "C1420247", "name": "C1420247#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706178", "name": "C1706178#ent", "pos": [20, 21]}}
{"token": ["Coexpression", "of", "native", "rabbit", "C1420247#ent", "<e1>", "or", "NF-SLN", "with", "C1706178#ent", "<e2>", "decreased", "the", "apparent", "affinity", "of", "C1706178#ent", "<e2>", "for", "Ca2", "+", "but", "stimulated", "maximal", "Ca2", "+", "uptake", "rates", "(", "Vmax", ")", "."], "h": {"id": "C1420247", "name": "C1420247#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706178", "name": "C1706178#ent", "pos": [9, 10]}}
{"token": ["The", "pharmacokinetics", "of", "C0087097#ent", "<e1>", "studied", "in", "five", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "and", "five", "normal", "volunteers", "determine", "whether", "data", "derived", "from", "normals", "could", "be", "applied", "to", "RA", "patients", "."], "h": {"id": "C0087097", "name": "C0087097#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}}
{"token": ["The", "first", "compared", "C0087097#ent", "<e1>", "phenylbutazone", "and", "placebo", "in", "C0003873#ent", "<e2>"], "h": {"id": "C0087097", "name": "C0087097#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [9, 10]}}
{"token": ["Average", "daily", "dose", "of", "C0087097#ent", "<e1>", "1141", "mg", "for", "patients", "with", "C0003873#ent", "<e2>", "and", "953", "mg", "for", "patients", "with", "osteoarthritis", "."], "h": {"id": "C0087097", "name": "C0087097#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}}
{"token": ["Several", "of", "these", "genes", "are", "associated", "with", "disorders", ",", "like", "KAL1", "(", "C0162809#ent", "<e1>", ",", "steroid", "sulfatase", "STS", ")", "(", "X-linked", "ichtyosis", ",", "and", "arylsulfatase", "E", "C1412558#ent", "<e2>", ")", "(", "chondrodysplasia", "punctata", "."], "h": {"id": "C0162809", "name": "C0162809#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412558", "name": "C1412558#ent", "pos": [26, 27]}}
{"token": ["C0403399#ent", "<e1>", "usually", "presented", "with", "heavy", "proteinuria", "hypoproteinaemia", ",", "oedema", "and", "C0020473#ent", "<e2>", "in", "a", "child", "from", "its", "birth", "until", "the", "age", "of", "3", "months", "."], "h": {"id": "C0403399", "name": "C0403399#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [11, 12]}}
{"token": ["C0872351#ent", "<e1>", "of", "control", "3T3", "fibroblasts", "and", "3T3", "cells", "expressing", "transfected", "C1334863#ent", "<e2>", "or", "N-cadherin", "have", "been", "used", "as", "a", "culture", "substratum", "rat", "hippocampal", "neurons", "."], "h": {"id": "C0872351", "name": "C0872351#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [11, 12]}}
{"token": ["We", "have", "used", "C0872351#ent", "<e1>", "of", "control", "3T3", "cells", "3T3", "cells", "expressing", "transfected", "human", "neural", "cell", "adhesion", "molecule", "C1334863#ent", "<e2>", ")", "or", "chick", "N-cadherin", "as", "a", "culture", "substrate", "PC12", "cells"], "h": {"id": "C0872351", "name": "C0872351#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [18, 19]}}
{"token": ["Cortical", "and", "C0392557#ent", "<e1>", "less", "common", "and", "severe", "in", "the", "C0206368#ent", "<e2>", "while", "the", "reverse", "is", "true", "for", "nuclear", "cataract"], "h": {"id": "C0392557", "name": "C0392557#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0206368", "name": "C0206368#ent", "pos": [10, 11]}}
{"token": ["To", "study", "the", "anti-tumor", "effect", "of", "C0076316#ent", "<e1>", "(", "Tet", ")", "combined", "with", "C0093999#ent", "<e2>", "(", "Nap", ")", "on", "the", "human", "liver", "cancer", "cell", "line", ",", "and", "explore", "its", "mechanism", "."], "h": {"id": "C0076316", "name": "C0076316#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0093999", "name": "C0093999#ent", "pos": [13, 14]}}
{"token": ["C0276252#ent", "<e1>", "not", "a", "cause", "of", "C0302809#ent", "<e2>", "or", "irreversible", "liver", "dysfunction", "any", "of", "the", "13", "cases", "."], "h": {"id": "C0276252", "name": "C0276252#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0302809", "name": "C0302809#ent", "pos": [6, 7]}}
{"token": ["Progesterone", "generally", "maintained", "procoagulant", "(", "thrombin", ",", "fibrinogen", ",", "and", "coagulation", "factor", "XIII", ",", "whereas", "C0002144#ent", "<e1>", "increased", "anticoagulant", "protein", "expression", "(", "tissue-type", "plasminogen", "activator", "C0872913#ent", "<e2>", ")", "."], "h": {"id": "C0002144", "name": "C0002144#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0872913", "name": "C0872913#ent", "pos": [25, 26]}}
{"token": ["The", "dihydropyridine", "(", "C0220821#ent", "<e1>", ")", "3", "was", "dehydrogenated", "with", "ammonium", "cerium", "nitrate", "(", "C1334912#ent", "<e2>", ")", "to", "give", "the", "pyridine", "(", "Py", ")", "4", "."], "h": {"id": "C0220821", "name": "C0220821#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334912", "name": "C1334912#ent", "pos": [14, 15]}}
{"token": ["Use", "of", "C1334435#ent", "<e1>", "with", "or", "without", "C0812312#ent", "<e2>", "transfected", "into", "B16", "cells", "indicated", "that", "RA", "induced", "a", "four-", "to", "fivefold", "increase", "in", "AP-1", "transcriptional", "activity"], "h": {"id": "C1334435", "name": "C1334435#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [7, 8]}}
{"token": ["The", "C2347281#ent", "<e1>", "contain", "several", "C1412821#ent", "<e2>", "ORFs", ")", "."], "h": {"id": "C2347281", "name": "C2347281#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [5, 6]}}
{"token": ["Processing", "of", "the", "2.0-kb", "LAT", "to", "form", "the", "spliced", "C2347281#ent", "<e1>", "preserves", "two", "C1412821#ent", "<e2>", "ORFs", ")", "at", "the", "3", "'", "end", "of", "the", "C2347281#ent", "<e1>", ";", "no", "new", "ORFs", "are", "created", "."], "h": {"id": "C2347281", "name": "C2347281#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [13, 14]}}
{"token": ["In", "these", "cases", ",", "many", "people", "developed", "C0235031#ent", "<e1>", "as", "emesis", "and", "C2364135#ent", "<e2>", "."], "h": {"id": "C0235031", "name": "C0235031#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "positive", "autoregulation", "of", "the", "beta", "2-adrenergic", "receptor", "gene", "to", "occur", "through", "receptor-mediated", "stimulation", "of", "C1382029#ent", "<e1>", "with", "consequent", "activation", "of", "cAMP", "response", "element-binding", "protein", "stimulation", "of", "C1704463#ent", "<e2>"], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704463", "name": "C1704463#ent", "pos": [28, 29]}}
{"token": ["A", "patient", "with", "a", "C0013370#ent", "<e1>", "with", "intestinal", "tuberculosis", "a", "sudden", "onset", "C0000737#ent", "<e2>", "mucoid", "diarrhea", "anorexia", ",", "fever", "and", "vomiting", "with", "signs", "of", "positive", "peritoneal", "irritation"], "h": {"id": "C0013370", "name": "C0013370#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [12, 13]}}
{"token": ["Recently", ",", "we", "demonstrated", "that", "the", "transcriptional", "regulating", "protein", "132", "kDa", "(", "C1705389#ent", "<e1>", ")", "acts", "as", "a", "coactivator", "of", "C2698421#ent", "<e2>", "to", "regulate", "human", "P450scc", "gene", "transcription", "human", "adrenal", "NCI-H295", "cells", "."], "h": {"id": "C1705389", "name": "C1705389#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2698421", "name": "C2698421#ent", "pos": [20, 21]}}
{"token": ["The", "dependence", "on", "C1332770#ent", "<e1>", "phosphorylation", "for", "complex", "formation", "with", "C2698947#ent", "<e2>", "SH2", "domains", "in", "vitro", "consistent", "with", "analysis", "of", "the", "native", "p120.p190", "complexes", "formed", "in", "vivo"], "h": {"id": "C1332770", "name": "C1332770#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2698947", "name": "C2698947#ent", "pos": [10, 11]}}
{"token": ["IL-15", "is", "known", "to", "be", "involved", "in", "many", "C1290884#ent", "<e1>", "such", "as", "rheumatoid", "arthritis", "sarcoidosis", ",", "inflammatory", "bowel", "diseases", "C1739108#ent", "<e2>", "etc", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1739108", "name": "C1739108#ent", "pos": [19, 20]}}
{"token": ["The", "influence", "of", "anti-inflammatory", "steroids", "hydrocortisone", ",", "prednisone", ",", "dexamathasone", ")", "upon", "C0013765#ent", "<e1>", "content", "in", "C0023899#ent", "<e2>", "was", "investigated", "in", "healthy", "and", "CCl4", "intoxicated", "rats", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["C0524928#ent", "<e1>", "spin-lattice", "relaxation", "rates", "of", "an", "anti-inflammatory", "drug", "C0031990#ent", "<e2>", ",", "have", "been", "measured", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [9, 10]}}
{"token": ["In", "vaginal", "material", "following", "could", "not", "be", "determined", ":", "Adenylatkinase", "(", "AK", ")", "using", "starch", "gel", "electrophoresis", "C0073873#ent", "<e1>", "EsD", ")", "using", "cellulose", "acetate", "membrane", "electrophoresis", "and", "C1415104#ent", "<e2>", "GLO", ")", "using", "agarose", "gel", "thin-layer", "electrophoresis"], "h": {"id": "C0073873", "name": "C0073873#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415104", "name": "C1415104#ent", "pos": [27, 28]}}
{"token": ["For", "systemic", "treatment", "systemically", "applicable", "C0360363#ent", "<e1>", "fluconazole", ",", "itraconazole", ")", ",", "C0076110#ent", "<e2>", "and", "griseofulvine", "are", "in", "use", "."], "h": {"id": "C0360363", "name": "C0360363#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [12, 13]}}
{"token": ["We", "evaluated", "the", "effect", "of", "long-term", "C0003280#ent", "<e1>", "treatment", "(", "enoxaparin", "vs", "C0010206#ent", "<e2>", ")", "in", "patients", "with", "deep", "venous", "thrombosis", "DVT", ")", "as", "to", "incidence", "of", "post-thrombotic", "syndrome", "PTS", ")", "and", "recurrent", "venous", "thromboembolism"], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010206", "name": "C0010206#ent", "pos": [12, 13]}}
{"token": ["In", "this", "feasibility", "study", "HRA", "was", "used", "without", "incident", "in", "six", "patients", "every", "24", "h", "to", "calculate", "the", "trend", "of", "the", "evolving", "C0003280#ent", "<e1>", "effect", "of", "C0010206#ent", "<e2>", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0010206", "name": "C0010206#ent", "pos": [26, 27]}}
{"token": ["In", "vitro", "C0066685#ent", "<e1>", "exhibited", "a", "higher", "inhibitory", "potency", "than", "C0014025#ent", "<e2>", "against", "both", "plasma", "ACE", "and", "purified", "ACE", "from", "rabbit", "lung", "."], "h": {"id": "C0066685", "name": "C0066685#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [10, 11]}}
{"token": ["C0030071#ent", "<e1>", "is", "often", "used", "as", "a", "decongestant", "in", "C0009443#ent", "<e2>", "patients", "who", "are", "suffering", "from", "nasal", "obstruction"], "h": {"id": "C0030071", "name": "C0030071#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [9, 10]}}
{"token": ["The", "nasal", "decongestants", "C0030071#ent", "<e1>", "and", "xylometazoline", "are", "frequently", "used", "in", "the", "topical", "treatment", "C0009443#ent", "<e2>", "and", "sinusitis", "."], "h": {"id": "C0030071", "name": "C0030071#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [14, 15]}}
{"token": ["This", "double-blind", ",", "placebo-controlled", "study", "the", "effects", "of", "ACE", "inhibitor", "C0072857#ent", "<e1>", ",", "on", "the", "functional", "status", "elderly", "frail", "C0018801#ent", "<e2>", "patients", "with", "preserved", "systolic", "function"], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["Other", "phenothiazine", "calmodulin", "inhibitors", ",", "trifluoperazine", "and", "C0008286#ent", "<e1>", ",", "also", "intensified", "the", "cytotoxic", "effect", "EGF-PE", ",", "whereas", "C0130379#ent", "<e2>", "W7", ")", "had", "no", "such", "effect", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0130379", "name": "C0130379#ent", "pos": [18, 19]}}
{"token": ["In", "both", "insulin-sensitive", "and", "insulin-resistant", "persons", ",", "RNA", "quantities", "of", "GLUT4", ",", "c-jun", ",", "C0087140#ent", "<e1>", ",", "and", "the", "C1334133#ent", "<e2>", "not", "change", "over", "the", "period", "of", "insulin", "infusion", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "adipogenic", "marker", "genes", "(", "for", "example", ",", "those", "encoding", "PPAR-gamma2", ",", "C1706040#ent", "<e1>", ",", "lipoprotein", "lipase", "adipsin", ")", "are", "also", "inhibited", "by", "C1540075#ent", "<e2>", "."], "h": {"id": "C1706040", "name": "C1706040#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1540075", "name": "C1540075#ent", "pos": [24, 25]}}
{"token": ["This", "array", "of", "phenotypes", "is", "identical", "to", "that", "of", "mei-W68", "mutants", ";", "mei-W68", "encodes", "the", "Drosophila", "C1705996#ent", "<e1>", "is", "proposed", "to", "be", "an", "C0014442#ent", "<e2>", "required", "for", "DSB", "formation", "."], "h": {"id": "C1705996", "name": "C1705996#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [23, 24]}}
{"token": ["In", "the", "sera", "of", "patients", "with", "C0004364#ent", "<e1>", "slightly", "enhanced", "sHLA-DR", "values", "were", "found", "(", "C3495559#ent", "<e2>", "median", "2.0", "ng/ml", ",", "lupus", "erythematosus", "1.5", "ng/ml", ",", "diabetes", "mellitus", "2.1", "ng/ml", ")", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [15, 16]}}
{"token": ["Both", "DON", "and", "C1705550#ent", "<e1>", "stimulate", "placental", "alkaline", "phosphatase", "expression", ",", "but", "only", "C0025677#ent", "<e2>", "and", "DON", "stimulate", "cholesterol", "side", "chain", "cleavage", "enzyme", "gene", "expression", "."], "h": {"id": "C1705550", "name": "C1705550#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [13, 14]}}
{"token": ["Electron", "microscopy", "mapping", "with", "restriction", "C3540790#ent", "<e1>", "show", "the", "deletion", "of", "a", "complete", "C0035900#ent", "<e2>", "of", "the", "three", "present", "in", "the", "original", "strain", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035900", "name": "C0035900#ent", "pos": [13, 14]}}
{"token": ["Scrutiny", "of", "the", "nuclear", "receptors", "augmented", "C1418776#ent", "<e1>", "gamma", "and", "reduced", "liver", "X", "receptor-alpha", "HIEC-6", "overexpressing", "C1705674#ent", "<e2>", "."], "h": {"id": "C1418776", "name": "C1418776#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705674", "name": "C1705674#ent", "pos": [16, 17]}}
{"token": ["Resistance", "to", "these", "compounds", "of", "C0017536#ent", "<e1>", "were", "described", "and", "in", "these", "cases", ",", "treatment", "by", "C0034403#ent", "<e2>", "or", "nitazoxanide", "are", "possible", "alternatives", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0034403", "name": "C0034403#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "a", "patient", "(", "W.B.", ")", "with", "chronic", "symptomatic", "C0017536#ent", "<e1>", "despite", "seven", "separate", "courses", "of", "either", "C0034403#ent", "<e2>", "or", "metronidazole", "who", "was", "cured", "by", "combined", "C0034403#ent", "<e2>", "and", "metronidazole", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0034403", "name": "C0034403#ent", "pos": [18, 19]}}
{"token": ["Unlike", "many", "other", "proteins", "that", "respond", "to", "DNA", "damage", "the", "response", "of", "C1427045#ent", "<e1>", "appears", "to", "be", "independent", "of", "C3711796#ent", "<e2>", "Mutated", "and", "p53", ",", "but", "dependent", "on", "DNA-dependent", "protein", "kinase", "activity"], "h": {"id": "C1427045", "name": "C1427045#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3711796", "name": "C3711796#ent", "pos": [19, 20]}}
{"token": ["For", "example", ",", "benzoate", ",", "degraded", "via", "the", "C0054858#ent", "<e1>", "was", "consumed", "in", "preference", "to", "C0000500#ent", "<e2>", ",", "degraded", "via", "the", "protocatechuate", "branch", "when", "both", "compounds", "were", "present", "."], "h": {"id": "C0054858", "name": "C0054858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000500", "name": "C0000500#ent", "pos": [15, 16]}}
{"token": ["We", "find", "that", "one", "of", "these", "factors", ",", "termed", "E4F", ",", "is", "increased", "at", "least", "10-fold", "in", "extracts", "prepared", "from", "C1865868#ent", "<e1>", "infected", "cells", "and", "that", "the", "increase", "requires", "the", "C1709313#ent", "<e2>"], "h": {"id": "C1865868", "name": "C1865868#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [30, 31]}}
{"token": ["Analysis", "of", "MAP", "kinase", "revealed", "a", "transient", "activation", "of", "C0248813#ent", "<e1>", "JNK", ")", "and", "C1366876#ent", "<e2>", "after", "LPS", "stimulation", "."], "h": {"id": "C0248813", "name": "C0248813#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [14, 15]}}
{"token": ["DNA", "unmethylation", "histone", "methylation", "the", "transcription", "start", "site", "of", "the", "C1705316#ent", "<e1>", "promoter", "triggers", "the", "recruitment", "of", "histone", "acetyltransferase", "C1540026#ent", "<e2>", ")", "activity", ",", "allowing", "C1705316#ent", "<e1>", "transcription", "."], "h": {"id": "C1705316", "name": "C1705316#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1540026", "name": "C1540026#ent", "pos": [19, 20]}}
{"token": ["This", "purification", "step", "has", "allowed", "us", "to", "convincingly", "demonstrate", "that", "the", "C0075018#ent", "<e1>", "can", "be", "labeled", "with", "C3539946#ent", "<e2>", "and", "is", "a", "necessary", "step", "for", "detecting", "amino", "acid-labeled", "CSPG", "."], "h": {"id": "C0075018", "name": "C0075018#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [17, 18]}}
{"token": ["Associated", "with", "target", "organ", "toxicity", "is", "selective", "arylation", "of", "C0086376#ent", "<e1>", ",", "with", "a", "58-kDa", "C0000970#ent", "<e2>", "58-ABP", ")", "being", "the", "most", "prominent", "cytosolic", "target", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [15, 16]}}
{"token": ["Identification", "of", "C0086376#ent", "<e1>", "that", "covalently", "bind", "acetaminophen", "(", "C0000970#ent", "<e2>", ")", "is", "essential", "for", "a", "clearer", "understanding", "of", "the", "hepatotoxicity", "that", "results", "after", "an", "C0000970#ent", "<e2>", "overdose", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [9, 10]}}
{"token": ["Going", "back", "to", "the", "late", "sixties", "one", "way", "of", "helping", "has", "been", "to", "integrate", "C1417725#ent", "<e1>", "officers", "into", "the", "C0671819#ent", "<e2>", "and", "vice", "versa", "."], "h": {"id": "C1417725", "name": "C1417725#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0671819", "name": "C0671819#ent", "pos": [19, 20]}}
{"token": ["Inactivated", "C0019159#ent", "<e1>", "and", "FCV", "were", "captured", "by", "C1334043#ent", "<e2>"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "suggest", "that", "phosphorylation", "of", "C0812222#ent", "<e1>", "by", "C1412097#ent", "<e2>", "impairs", "the", "inhibition", "of", "p53", "by", "C0812222#ent", "<e1>", ",", "hence", "defining", "a", "novel", "mechanism", "by", "which", "C1412097#ent", "<e2>", "activates", "p53", "."], "h": {"id": "C0812222", "name": "C0812222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [9, 10]}}
{"token": ["Levels", "of", "C1452577#ent", "<e1>", "or", "DNMT1", "mRNAs", "and", "C0086376#ent", "<e2>", "were", "markedly", "decreased", "(", "up", "to", "80", "%", ")", "on", "transfecting", "these", "siRNAs", "into", "the", "ovarian", "cancer", "cell", "line", "."], "h": {"id": "C1452577", "name": "C1452577#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["The", "C3713294#ent", "<e1>", "values", "are", "being", "used", "until", "the", "C1705796#ent", "<e2>", "values", "become", "effective", "."], "h": {"id": "C3713294", "name": "C3713294#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705796", "name": "C1705796#ent", "pos": [9, 10]}}
{"token": ["A", "similar", "action", "on", "human", "C0083183#ent", "<e1>", "could", "be", "a", "cause", "of", "C0022951#ent", "<e2>"], "h": {"id": "C0083183", "name": "C0083183#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0022951", "name": "C0022951#ent", "pos": [12, 13]}}
{"token": ["Single", "doses", "a", "chewable", "C0083183#ent", "<e1>", "reduced", "the", "concentration", "of", "expired", "hydrogen", "and", "symptoms", "of", "C0022951#ent", "<e2>", "a", "lactose", "challenge", "."], "h": {"id": "C0083183", "name": "C0083183#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0022951", "name": "C0022951#ent", "pos": [15, 16]}}
{"token": ["Twenty-one", "C1875400#ent", "<e1>", "of", "Aphanomyces", "invadans", "the", "fungal", "pathogen", "associated", "with", "C0016154#ent", "<e2>", "ulcerative", "syndrome", "(", "EUS", ")", ",", "were", "compared", "with", "other", "Oomycete", "fungi", "terms", "of", "their", "pyrolysis", "mass", "spectrometry", "PvMS", ")", "profiles", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0016154", "name": "C0016154#ent", "pos": [11, 12]}}
{"token": ["Novel", "antagonists", "of", "the", "glycineB", "site", "of", "the", "NMDA", "receptor", "C4049869#ent", "<e1>", "2/570", ",", "C4049869#ent", "<e1>", "2/576", ")", ",", "and", "an", "C1516869#ent", "<e1>", "NBQX", "were", "tested", "in", "3-min", "global", "ischaemia", "gerbils", "."], "h": {"id": "C4049869", "name": "C4049869#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [21, 22]}}
{"token": ["In", "Japan", ",", "43", "cases", "of", "C0038034#ent", "<e1>", "have", "been", "treated", "with", "C0064113#ent", "<e2>", ",", "and", "38", "cases", "(", "88", "%", ")", "have", "been", "assessed", "as", "effective", "or", "better", "."], "h": {"id": "C0038034", "name": "C0038034#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [12, 13]}}
{"token": ["Class", "III", "plant", "peroxidases", "(", "C0633225#ent", "<e1>", ",", "which", "are", "encoded", "by", "C0017363#ent", "<e2>", "land", "plants", "are", "involved", "in", "several", "important", "physiological", "and", "developmental", "processes"], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [12, 13]}}
{"token": ["Among", "the", "C0017337#ent", "<e1>", "overexpressed", "by", "gastrin", ",", "we", "paid", "particular", "attention", "to", "tenascin-C", ",", "C3274822#ent", "<e2>", "and", "MLCK", "C0017337#ent", "<e1>", "because", "their", "direct", "involvement", "in", "cell", "migration", "features", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}}
{"token": ["In", "other", "cases", ",", "diagnoses", "of", "C0030283#ent", "<e1>", "5", "patients", "or", "C0013502#ent", "<e2>", "1", "patient", "were", "made", "."], "h": {"id": "C0030283", "name": "C0030283#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [11, 12]}}
{"token": ["Although", "the", "tumor", "displayed", "C1997362#ent", "<e1>", "morphology", ",", "it", "showed", "strong", "reactivity", "for", "alpha-smooth", "C0968461#ent", "<e2>", "h-caldesmon", ",", "and", "was", "negative", "for", "neurogenic", "markers", ",", "except", "CD56", ",", "by", "immunohistochemistry", "."], "h": {"id": "C1997362", "name": "C1997362#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0968461", "name": "C0968461#ent", "pos": [14, 15]}}
{"token": ["After", "completion", "of", "the", "combined", "therapy", "C1704799#ent", "<e1>", ",", "there", "was", "C1861185#ent", "<e2>", "was", "successfully", "treated", "by", "splenectomy", "."], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1861185", "name": "C1861185#ent", "pos": [11, 12]}}
{"token": ["The", "data", "indicate", "that", "C0034678#ent", "<e1>", "have", "an", "inhibitory", "effect", "on", "the", "growth", "of", "C3539667#ent", "<e2>", "95", "-", "2", "cells", "and", "a", "cross-talk", "with", "the", "estrogen", "pathway", "estrogen-responsive", "endometrial", "cancer", "cells", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539667", "name": "C3539667#ent", "pos": [14, 15]}}
{"token": ["Young", "dogs", "significantly", "slower", "RLs", "and", "higher", "C0034678#ent", "<e1>", "and", "showed", "C3539667#ent", "<e2>", "slowing", "with", "greater", "complexity", ",", "compared", "with", "aged", "dogs", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539667", "name": "C3539667#ent", "pos": [11, 12]}}
{"token": ["Aerobically", ",", "the", "onset", "of", "hemolysis", "was", "partially", "inhibited", "by", "NaN3", "and", "by", "C0006507#ent", "<e1>", "(", "BHT", ")", "but", "not", "by", "C0669516#ent", "<e2>", "SOD", ")", "."], "h": {"id": "C0006507", "name": "C0006507#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [21, 22]}}
{"token": ["Here", "we", "describe", "a", "second", "genetic", "variant", "C1417613#ent", "<e1>", "in", "the", "mouse", ",", "C1864923#ent", "<e2>", "nclf", "."], "h": {"id": "C1417613", "name": "C1417613#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1864923", "name": "C1864923#ent", "pos": [13, 14]}}
{"token": ["Only", "minor", "differences", "were", "observed", "in", "the", "characteristics", "of", "these", "C3541394#ent", "<e1>", "when", "the", "C0757672#ent", "<e2>", "were", "prepared", "from", "placentae", "of", "7", "-", "8", "weeks", "of", "pregnancy", "or", "from", "normal", "term", "placenta", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0757672", "name": "C0757672#ent", "pos": [14, 15]}}
{"token": ["The", "results", "of", "the", "present", "study", "support", "the", "usefulness", "of", "C0031507#ent", "<e1>", "as", "a", "disease-modifying", "drug", "C0038013#ent", "<e2>"], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "efficacy", "of", "C0031507#ent", "<e1>", "in", "modifying", "the", "course", "of", "C0038013#ent", "<e2>", "RA", ")", "by", "comparing", "it", "to", "gold", "(", "auranofin", ")", "and", "chloroquine", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [11, 12]}}
{"token": ["A", "C0920283#ent", "<e1>", "called", "chloroplast", "DNA", "ctDNA", ")", "C1333949#ent", "<e2>", "was", "purified", "to", "apparent", "homogeneity", "from", "pea", "(", "Pisum", "sativum", "."], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [8, 9]}}
{"token": ["C1866956#ent", "<e1>", "a", "significant", "risk", "in", "women", "with", "C0041408#ent", "<e2>", "is", "closely", "dependent", "on", "blood", "pressure"], "h": {"id": "C1866956", "name": "C1866956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041408", "name": "C0041408#ent", "pos": [8, 9]}}
{"token": ["The", "C0599295#ent", "<e1>", "C-reactive", "protein", "initiation", "of", "a", "C0020374#ent", "<e2>", "statin", ")", "is", "not", "known", "."], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [8, 9]}}
{"token": ["C0162508#ent", "<e1>", "synergizes", "with", "C1335877#ent", "<e2>", "to", "activate", "both", "the", "intact", "GL", "epsilon", "and", "a", "minimal", "heterologous", "promoter", "driven", "by", "the", "C0162508#ent", "<e1>", "and", "C1335877#ent", "<e2>", "sites", "of", "the", "mouse", "GL", "epsilon", "promoter", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335877", "name": "C1335877#ent", "pos": [4, 5]}}
{"token": ["There", "was", "no", "significant", "interaction", "between", "MTR", "and", "C1453956#ent", "<e1>", "genotype", "or", "between", "these", "genotypes", "and", "any", "of", "the", "C3714649#ent", "<e2>", "with", "respect", "to", "homocysteine", "concentrations", "."], "h": {"id": "C1453956", "name": "C1453956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "if", "this", "disorder", "is", "underdiagnosed", "in", "patients", "with", "end-stage", "renal", "disease", "C0035078#ent", "<e1>", ")", ",", "the", "frequency", "of", "unrecognized", "males", "with", "C0002986#ent", "<e2>", "chronic", "hemodialysis", "determined", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0002986", "name": "C0002986#ent", "pos": [23, 24]}}
{"token": ["The", "diseases", "causing", "C0035078#ent", "<e1>", "recipients", "were", "Alport", "syndrome", "amyloidosis", ",", "cystinosis", ",", "diabetes", "mellitus", "C0002986#ent", "<e2>", "familial", "nephritis", "gout", ",", "medullary", "cystic", "disease", "oxalosis", ",", "and", "systemic", "lupus", "erythematosus"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0002986", "name": "C0002986#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "whether", "synovial", "fluid", "C0876942#ent", "<e1>", ")", "levels", "and", "cell-surface", "expression", "of", "B", "lymphocyte", "stimulator", "BLyS", ")", "protein", "and", "C0876942#ent", "<e1>", "levels", "of", "APRIL", "are", "elevated", "in", "patients", "with", "C3899281#ent", "<e1>", "IA", ")", "."], "h": {"id": "C0876942", "name": "C0876942#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3899281", "name": "C3899281#ent", "pos": [30, 31]}}
{"token": ["In", "addition", ",", "a", "defect", "in", "the", "C0094209#ent", "<e1>", "DNA", "polymerase", "I", "homologous", "to", "the", "mammalian", "C0252912#ent", "<e2>", "and", "the", "yeast", "RAD27", "nucleases", ",", "leads", "to", "a", "marked", "increase", "in", "repeat", "expansions", "of", "several", "genetic", "disorders"], "h": {"id": "C0094209", "name": "C0094209#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0252912", "name": "C0252912#ent", "pos": [16, 17]}}
{"token": ["268", ",", "26400", "-", "26408", ")", "function", "to", "coordinate", "the", "C1420295#ent", "<e1>", "down-regulation", "of", "the", "C1366536#ent", "<e2>", "aging", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [15, 16]}}
{"token": ["ADF", "and", "cofilin", "shared", "a", "hexapeptide", "identical", "with", "the", "amino-terminal", "sequence", "of", "tropomyosin", "as", "well", "as", "the", "regions", "C1334043#ent", "<e1>", "to", "other", "actin-regulatory", "proteins", "including", "depactin", ",", "gelsolin", ",", "and", "C0072074#ent", "<e2>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0072074", "name": "C0072074#ent", "pos": [30, 31]}}
{"token": ["By", "contrast", ",", "we", "found", "cell-type-specific", "replication", "patterns", "for", "the", "C1334043#ent", "<e1>", ",", "unlinked", "profilin", "A", "(", "proA", ")", "and", "C0072074#ent", "<e2>", "proP", ")", "genes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0072074", "name": "C0072074#ent", "pos": [20, 21]}}
{"token": ["We", "conclude", "that", "LRP1", "and", "C1416920#ent", "<e1>", "polymorphisms", "are", "not", "responsible", "for", "high", "C1366370#ent", "<e2>", ":", "C", "levels", "in", "patients", "with", "VTE", "."], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [13, 14]}}
{"token": ["We", "now", "evaluated", "the", "binding", "to", "C1416920#ent", "<e1>", ",", "alpha2", "M", "*", ",", "FIXa", "and", "C1366370#ent", "<e2>", "light", "chain", "triplicate", "repeat-fragments", "of", "not", "only", "clusters", "II", "but", "also", "of", "cluster", "IV"], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [15, 16]}}
{"token": ["It", "functions", "as", "a", "polynucleotide", "kinase", "as", "a", "C0031640#ent", "<e1>", "and", "as", "an", "C0032589#ent", "<e2>"], "h": {"id": "C0031640", "name": "C0031640#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032589", "name": "C0032589#ent", "pos": [13, 14]}}
{"token": ["One", "possible", "C3275238#ent", "<e1>", "could", "act", "as", "a", "transcriptional", "regulator", "both", "hypoxia", "and", "reoxygenation", "C0812327#ent", "<e2>", "the", "heat", "shock", "transcription", "factor"], "h": {"id": "C3275238", "name": "C3275238#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [14, 15]}}
{"token": ["This", "cooperation", "between", "SPI-1", "and", "C1826467#ent", "<e1>", "to", "induce", "primary", "C0242991#ent", "<e2>", "that", "progression", "of", "Friend", "erythroleukemia", "depends", "upon", "inter-dependent", "interactions", "between", "the", "molecular", "events", "of", "the", "early", "and", "late", "phase", "the", "disease", "."], "h": {"id": "C1826467", "name": "C1826467#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242991", "name": "C0242991#ent", "pos": [10, 11]}}
{"token": ["Recent", "evidence", "also", "indicates", "the", "involvement", "of", "pro-inflammatory", "cytokines", "in", "the", "pathogenesis", "of", "C0004153#ent", "<e1>", "and", "major", "depression", ",", "and", "conditions", "such", "as", "C2936179#ent", "<e2>", "metabolic", "syndrome", "sleep", "disturbances"], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2936179", "name": "C2936179#ent", "pos": [23, 24]}}
{"token": ["SMA", "injury", "nephrectomy", "most", "commonly", "occurs", "with", "large", "tumors", "or", "C0497156#ent", "<e1>", "with", "inadvertent", "injury", "or", "mistaken", "ligation", "of", "the", "C0026847#ent", "<e2>", "instead", "of", "the", "renal", "artery"], "h": {"id": "C0497156", "name": "C0497156#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026847", "name": "C0026847#ent", "pos": [20, 21]}}
{"token": ["Age-related", "macular", "degeneration", "C0017921#ent", "<e1>", ")", "is", "a", "late-onset", ",", "multifactorial", ",", "C0524851#ent", "<e2>", "the", "retina", "and", "the", "leading", "cause", "of", "irreversible", "vision", "loss", "in", "the", "elderly", "in", "the", "Western", "world"], "h": {"id": "C0017921", "name": "C0017921#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524851", "name": "C0524851#ent", "pos": [12, 13]}}
{"token": ["Mitochondrial", "dysfunctions", "been", "implicated", "in", "the", "pathophysiology", "of", "several", "age-related", "diseases", "including", "age-related", "macular", "degeneration", "C0017921#ent", "<e1>", ")", ",", "a", "progressive", "C0524851#ent", "<e2>", "primarily", "the", "retinal", "pigment", "epithelium", "RPE", ")", "."], "h": {"id": "C0017921", "name": "C0017921#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0524851", "name": "C0524851#ent", "pos": [21, 22]}}
{"token": ["4,4'-Diethylaminoethoxyhexestrol", "(", "DEAEH", ")", ",", "C0002598#ent", "<e1>", ",", "and", "perhexiline", "cause", "C2711227#ent", "<e2>", "in", "humans", "."], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [11, 12]}}
{"token": ["We", "have", "also", "recently", "demonstrated", "that", "loss", "of", "C0919496#ent", "<e1>", "expression", "in", "metastatic", "melanoma", "cells", "in", "C0221406#ent", "<e2>", "of", "the", "thrombin", "receptor", "PAR-1", "."], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [16, 17]}}
{"token": ["Live-cell", "imaging", ",", "fluorescent", "kinase", "activity", "reporters", ",", "and", "RNA", "interference", "techniques", "that", "AKAP-Lbc", "couples", "activation", "of", "protein", "kinase", "D", "C1538716#ent", "<e1>", ")", "with", "the", "phosphorylation-dependent", "nuclear", "export", "of", "the", "C2718090#ent", "<e2>", "HDAC5", "."], "h": {"id": "C1538716", "name": "C1538716#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2718090", "name": "C2718090#ent", "pos": [30, 31]}}
{"token": ["C0878681#ent", "<e1>", "an", "X-linked", "tubulopathy", "caused", "by", "mutations", "affecting", "the", "C1413451#ent", "<e2>", "chloride/proton", "antiporter", "ClC-5", "."], "h": {"id": "C0878681", "name": "C0878681#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413451", "name": "C1413451#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "CLC-5-deficient", "mice", "provide", "a", "model", "for", "C0878681#ent", "<e1>", "this", "will", "help", "in", "elucidating", "the", "function", "of", "this", "C1413451#ent", "<e2>", "endocytosis", "and", "renal", "calcium", "homeostasis"], "h": {"id": "C0878681", "name": "C0878681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413451", "name": "C1413451#ent", "pos": [19, 20]}}
{"token": ["Lipolysis", "was", "stimulated", "by", "isoproterenol", ",", "C0055730#ent", "<e1>", "or", "ractopamine", "but", "not", "by", "C0008932#ent", "<e2>", "."], "h": {"id": "C0055730", "name": "C0055730#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008932", "name": "C0008932#ent", "pos": [13, 14]}}
{"token": ["The", "hormones", "glucose-dependent", "insulinotropic", "polypeptide", "GIP", ")", "and", "C0061355#ent", "<e1>", "act", "on", "the", "C0771711#ent", "<e2>", "to", "potentiate", "glucose-induced", "insulin", "secretion", "enteroinsular", "axis", ")", "."], "h": {"id": "C0061355", "name": "C0061355#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [13, 14]}}
{"token": ["The", "C1416487#ent", "<e1>", "associate", "with", "either", "the", "beta", "1-", "or", "C1416496#ent", "<e2>", "form", "two", "unique", "adhesion", "receptors", "alpha", "4", "beta", "1", "and", "alpha", "4", "beta", "7"], "h": {"id": "C1416487", "name": "C1416487#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416496", "name": "C1416496#ent", "pos": [10, 11]}}
{"token": ["The", "influence", "of", "alcohol", ",", "ascorbic", "acid", "C0031428#ent", "<e1>", "and", "thiocyanic", "acid", "the", "formation", "of", "C0008188#ent", "<e2>", "from", "chlordiazepoxide", "and", "nitrous", "acid", "investigated", "by", "means", "of", "high-performance", "liquid", "chromatography"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [15, 16]}}
{"token": ["C0078257#ent", "<e1>", "(", "NVB", ")", "is", "a", "novel", "C0042672#ent", "<e2>", "FDA", "approved", "for", "use", "in", "some", "advanced", "carcinomas", "."], "h": {"id": "C0078257", "name": "C0078257#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [8, 9]}}
{"token": ["C0078257#ent", "<e1>", "is", "a", "potent", "as", "the", "other", "C0042672#ent", "<e2>", "inhibit", "mitotic", "microtubule", "polymerization"], "h": {"id": "C0078257", "name": "C0078257#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [8, 9]}}
{"token": ["C0078257#ent", "<e1>", "(", "Navelbine", ")", "is", "a", "new", "C0042672#ent", "<e2>", "chemically", "differs", "from", "vinblastine", "by", "substitutions", "on", "the", "catharantine", "moiety", "of", "the", "molecule", "."], "h": {"id": "C0078257", "name": "C0078257#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [8, 9]}}
{"token": ["Vav", ",", "a", "guanine", "nucleotide", "exchange", "factor", "members", "of", "the", "Rho", "family", "small", "C0018296#ent", "<e1>", ",", "is", "activated", "through", "engagement", "of", "B", "and", "C3273109#ent", "<e2>"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3273109", "name": "C3273109#ent", "pos": [23, 24]}}
{"token": ["According", "to", "the", "dosage", "interval", "C0022251#ent", "<e1>", "dinitrate", ",", "66", "patients", "with", "C0010068#ent", "<e2>", "divided", "into", "group", "A", "group", "B", "a", "random", ",", "control", "and", "double-blind", "method"], "h": {"id": "C0022251", "name": "C0022251#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [12, 13]}}
{"token": ["The", "aluminum", "in", "the", "cells", "was", "even", "more", "eliminated", "by", "washing", "with", "C1511755#ent", "<e1>", "when", "the", "duration", "of", "C3539738#ent", "<e2>", "+", "treatment", "was", "<", "20", "min", "."], "h": {"id": "C1511755", "name": "C1511755#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539738", "name": "C3539738#ent", "pos": [18, 19]}}
{"token": ["Chemical", "shift", "artifact", "(", "C0010592#ent", "<e1>", ")", "usually", "was", "present", "on", "either", "C2984132#ent", "<e2>", "PDWI", "or", "C2984132#ent", "<e2>", "T2WI", "but", "was", "not", "seen", "on", "FSE", "images", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2984132", "name": "C2984132#ent", "pos": [12, 13]}}
{"token": ["Similar", "precursors", "that", "produce", "C1334890#ent", "<e1>", "differentiation", "can", "be", "isolated", "from", "adult", "human", "C0240940#ent", "<e2>", "."], "h": {"id": "C1334890", "name": "C1334890#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0240940", "name": "C0240940#ent", "pos": [13, 14]}}
{"token": ["To", "study", "the", "expressions", "of", "Fas", "and", "C1515370#ent", "<e1>", "(", "FasL", ")", "genes", "in", "rats", "with", "C0001339#ent", "<e2>", "AP", ")", "and", "their", "relation", "to", "apoptosis", "of", "pancreatic", "acinar", "cells"], "h": {"id": "C1515370", "name": "C1515370#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [16, 17]}}
{"token": ["In", "this", "work", ",", "we", "sought", "to", "characterize", "the", "role", "of", "C1515370#ent", "<e1>", "FasL", ")", "in", "liver", "injury", "C0001339#ent", "<e2>"], "h": {"id": "C1515370", "name": "C1515370#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [18, 19]}}
{"token": ["Eight", "patients", "had", "FSH/LH", "insufficiency", ",", "5", "had", "C1565489#ent", "<e1>", "and", "6", "had", "C0035078#ent", "<e2>", "appropriately", "replaced", "."], "h": {"id": "C1565489", "name": "C1565489#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [13, 14]}}
{"token": ["In", "this", "case", ",", "C1268936#ent", "<e1>", "HUS", ")", "was", "associated", "with", "C0024141#ent", "<e2>", "."], "h": {"id": "C1268936", "name": "C1268936#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [11, 12]}}
{"token": ["Overexpression", "of", "Bcl-XL", "in", "HeLa", "cells", "blocked", "C0534519#ent", "<e1>", "activation", "by", "the", "C2001522#ent", "<e2>"], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2001522", "name": "C2001522#ent", "pos": [12, 13]}}
{"token": ["The", "results", "suggest", "that", "the", "105", "C0002085#ent", "<e1>", "has", "been", "replaced", "by", "100", "at", "C0024395#ent", "<e2>", "under", "the", "action", "of", "natural", "selection"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024395", "name": "C0024395#ent", "pos": [14, 15]}}
{"token": ["The", "C1366536#ent", "<e1>", "ligand", "binding", "domain", "displayed", "the", "highest", "affinity", "for", "C1538149#ent", "<e2>", ",", "but", "corepressor", "and", "coactivator", "binding", "interfaces", "did", "not", "contribute", "to", "C1538149#ent", "<e2>", "recruitment", "."], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [11, 12]}}
{"token": ["Translocations", "of", "the", "C1366536#ent", "<e1>", "RARalpha", ")", "locus", "with", "the", "C1538149#ent", "<e2>", "PLZF", ")", "or", "PML", "genes", "lead", "to", "expression", "of", "oncogenic", "PLZF-RARalpha", "or", "PML-RARalpha", "fusion", "proteins", "respectively", "."], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [10, 11]}}
{"token": ["Acute", "promyelocytic", "leukemia", "APL", ")", "originate", "from", "chromosomal", "translocations", "two", "types", "of", "fusion", "proteins", "involving", "the", "C1366536#ent", "<e1>", "RAR", "alpha", "and", "either", "the", "gene", "PML", "t(15;17", ")", ")", "or", "C1538149#ent", "<e2>", "(", "t(11;17", ")", ")", "."], "h": {"id": "C1366536", "name": "C1366536#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [29, 30]}}
{"token": ["In", "contrast", ",", "TNF-alpha", "production", "in", "response", "to", "okadaic", "acid", "inhibited", "by", "the", "TNF-converting", "enzyme", "inhibitor", "C0257713#ent", "<e1>", "staurosporin", "but", "was", "unaffected", "by", "either", "IL-1ra", ",", "C0011777#ent", "<e2>", "or", "NS-398", "."], "h": {"id": "C0257713", "name": "C0257713#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [26, 27]}}
{"token": ["When", "C3889446#ent", "<e1>", "in", "the", "ssc1", "-", "3", "mutant", "strain", "C1823091#ent", "<e2>", "suppresses", "the", "defect", "in", "mitochondrial", "protein", "import", "permissive", "conditions", "in", "vitro", "interacts", "directly", "with", "newly", "imported", "polypeptide", "chains"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823091", "name": "C1823091#ent", "pos": [10, 11]}}
{"token": ["A", "C1512488#ent", "<e1>", "neurophysin", "radioimmunoassay", "utilized", "to", "measure", "C1418208#ent", "<e2>", "in", "samples", "of", "unextracted", "rat", "plasma", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418208", "name": "C1418208#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "involvement", "of", "C1620185#ent", "<e1>", "in", "the", "metabolism", "of", "C0025887#ent", "<e2>", "has", "been", "proposed", "based", "on", "the", "interaction", "with", "theophylline", "which", "is", "mainly", "metabolized", "by", "C1620185#ent", "<e1>", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [5, 6]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0025887", "name": "C0025887#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "report", "on", "the", "cellular", "distribution", "by", "immunohistochemistry", ",", "of", "C1334507#ent", "<e1>", "MIF", ")", "and", "C1533698#ent", "<e2>", "iNOS", ")", "in", "this", "disease", ",", "and", "in", "sepsis", "."], "h": {"id": "C1334507", "name": "C1334507#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [16, 17]}}
{"token": ["The", "results", "suggests", "that", "circulating", "C1420314#ent", "<e1>", "is", "a", "reliable", "early", "marker", "of", "C0007785#ent", "<e2>", "and", "that", "this", "new", "sensitive", "C1420314#ent", "<e1>", "assay", "may", "be", "useful", "for", "diagnosing", "cerebral", "thrombosis"], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [13, 14]}}
{"token": ["Complementary", "C0011522#ent", "<e1>", "were", "cloned", "and", "found", "to", "be", "virtually", "identical", "to", "C1421249#ent", "<e2>", ",", "a", "human", "mRNA", "encoding", "a", "non-receptor", "protein", "tyrosine", "kinase", "previously", "unknown", "function", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [12, 13]}}
{"token": ["C0030956#ent", "<e1>", "removed", "by", "extraction", "in", "0.25", "mol/l", "C3256468#ent", "<e2>", "pH", "3.1", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3256468", "name": "C3256468#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "tumor", "multiplicity", "tumor-bearing", "animals", "was", "not", "significantly", "different", "among", "any", "of", "the", "three", "groups", "(", "C0015625#ent", "<e1>", ",", "C0047964#ent", "<e2>", ",", "CS", "+", "C0047964#ent", "<e2>", ")", "in", "which", "tumors", "were", "observed", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0047964", "name": "C0047964#ent", "pos": [20, 21]}}
{"token": ["Crude", "tumor", "incidences", ",", "as", "determined", "from", "gross", "observation", "of", "lung", "nodules", "were", "similar", "between", "the", "CS-exposed", "and", "C0015625#ent", "<e1>", "groups", ",", "and", "the", "C0047964#ent", "<e2>", "and", "CS", "+", "C0047964#ent", "<e2>", "groups", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0047964", "name": "C0047964#ent", "pos": [24, 25]}}
{"token": ["The", "DSIP", "delayed", "development", "of", "corazol", "kindling", "rats", ",", "prevented", "seizure", "induced", "with", "C0005372#ent", "<e1>", "and", "other", "C0035064#ent", "<e2>", "in", "mice", "."], "h": {"id": "C0005372", "name": "C0005372#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}}
{"token": ["However", ",", "its", "insensitivity", "to", "C0005372#ent", "<e1>", ",", "pentobarbitone", "and", "benzodiazepines", ",", "all", "potent", "C0035064#ent", "<e2>", "at", "typical", "GABAA", "receptors", "suggested", "that", "it", "may", "react", "atypically", "to", "other", "GABA", "agonists", "and", "antagonists", "."], "h": {"id": "C0005372", "name": "C0005372#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}}
{"token": ["In", "3T3-L1", "cells", "C0017757#ent", "<e1>", "overexpression", "stimulated", "the", "expression", "of", "most", "adipocyte", "marker", "C1417679#ent", "<e2>", "and", "elevated", "the", "levels", "of", "cellular", "free", "fatty", "acids", "triglyceride", ",", "and", "FFA", "release", "."], "h": {"id": "C0017757", "name": "C0017757#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", ",", "the", "incidence", "and", "clinical", "significance", "ST-segment", "fluctuation", "were", "studied", "before", "and", "after", "C0033497#ent", "<e1>", "in", "52", "patients", "with", "C0002962#ent", "<e2>"], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [23, 24]}}
{"token": ["In", "a", "variety", "of", "tumor", "types", "including", "those", "derived", "from", "the", "colon", "and", "breast", ",", "the", "C0812329#ent", "<e1>", "either", "overexpressed", "or", "C0669365#ent", "<e2>", "active", "in", "a", "large", "percentage", "of", "the", "tumors", "."], "h": {"id": "C0812329", "name": "C0812329#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [21, 22]}}
{"token": ["In", "C0522051#ent", "<e1>", "diagnostic", "considerations", "to", "include", "lung", "embolism", "C0155679#ent", "<e2>", "spontaneous", "pneumothorax", "acute", "dissecting", "aneurysm", "the", "aorta", "and", "diseases", "of", "the", "gastrointestinal", "tract", "well", "."], "h": {"id": "C0522051", "name": "C0522051#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0155679", "name": "C0155679#ent", "pos": [9, 10]}}
{"token": ["C0587248#ent", "<e1>", "a", "rare", "but", "increasingly", "recognized", "C0039082#ent", "<e2>", "of", "unknown", "etiology", "."], "h": {"id": "C0587248", "name": "C0587248#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [7, 8]}}
{"token": ["These", "results", "indicate", "that", "the", "stimulatory", "effect", "of", "KL", "+", "C0011816#ent", "<e1>", "is", "related", "to", "the", "modulation", "of", "C0162539#ent", "<e2>", "than", "to", "recruitment", "of", "BFU-Es", "with", "elevated", "HbF", "synthetic", "potential"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162539", "name": "C0162539#ent", "pos": [18, 19]}}
{"token": ["In", "normal", "sebaceous", "glands", "C0342384#ent", "<e1>", "is", "expressed", "in", "differentiated", "sebocytes", "and", "the", "transcription", "factor", "C0812304#ent", "<e2>", "is", "activated", "in", "sebocyte", "progenitors", ",", "suggesting", "a", "paracrine", "signaling", "."], "h": {"id": "C0342384", "name": "C0342384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812304", "name": "C0812304#ent", "pos": [15, 16]}}
{"token": ["The", "AR", "signaling", "axis", "C2936824#ent", "<e1>", "were", "elevated", "in", "the", "prostate", "glands", "C1336927#ent", "<e2>", "transgenic", "mice"], "h": {"id": "C2936824", "name": "C2936824#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336927", "name": "C1336927#ent", "pos": [12, 13]}}
{"token": ["C1417679#ent", "<e1>", "that", "encode", "the", "synthesis", "of", "these", "alpha", "and", "C1415155#ent", "<e2>", "potentially", "significant", "markers", "for", "those", "individuals", "that", "are", "prone", "to", "engage", "in", "heightened", "aggressive", "behavior", "the", "consumption", "of", "alcohol", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415155", "name": "C1415155#ent", "pos": [10, 11]}}
{"token": ["As", "an", "initial", "step", "to", "define", "the", "roles", "that", "particular", "gamma", "subunit", "play", "in", "signaling", ",", "we", "have", "begun", "to", "clone", "and", "characterize", "those", "C1417679#ent", "<e1>", "that", "encode", "C1415155#ent", "<e2>", "within", "neural", "tissue"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1415155", "name": "C1415155#ent", "pos": [28, 29]}}
{"token": ["Less", "effective", "were", "C0301713#ent", "<e1>", "ring", "substituents", ";", "ineffective", "were", "basic", "C3539946#ent", "<e2>", "omega-amino", "isomers", "of", "norleucine", "and", "aminooctanoate", "."], "h": {"id": "C0301713", "name": "C0301713#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [11, 12]}}
{"token": ["Among", "both", "Tyr(352", ")", "and", "Phe(504", ")", "mutants", ",", "the", "other", "C0301713#ent", "<e1>", "galactose", "transport", "no", "other", "C3539946#ent", "<e2>", "high", "affinity", "transport", "activity", "."], "h": {"id": "C0301713", "name": "C0301713#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [17, 18]}}
{"token": ["Comparison", "of", "the", "amino", "terminal", "sequences", "the", "heavy", "and", "the", "C0806492#ent", "<e1>", "bovine", "cathepsin", "L", "that", "of", "bovine", "cathepsin", "S", "indicates", "that", "the", "C3540772#ent", "<e2>", "are", "structurally", "different", "."], "h": {"id": "C0806492", "name": "C0806492#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [23, 24]}}
{"token": ["Causes", "include", "C0393576#ent", "<e1>", ",", "pantothenate", "kinase-associated", "neurodegeneration", "Lesch-Nyhan", "syndrome", "and", "postanoxic", "and", "C0393593#ent", "<e2>"], "h": {"id": "C0393576", "name": "C0393576#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [13, 14]}}
{"token": ["Comparison", "of", "the", "dose-dependent", "effects", "of", "C0076678#ent", "<e1>", "on", "ICa", "and", "C1416611#ent", "<e2>", "suggested", "that", "C0076678#ent", "<e1>", "may", "selectively", "inhibit", "catecholamine-induced", "increase", "of", "C1416611#ent", "<e2>", "at", "the", "therapeutic", "concentrations"], "h": {"id": "C1416611", "name": "C1416611#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0076678", "name": "C0076678#ent", "pos": [6, 7]}}
{"token": ["C2239507#ent", "<e1>", "is", "located", "within", "capillaries", "of", "muscle", "and", "adipose", "tissue", "and", "expression", "of", "C2239507#ent", "<e1>", "in", "Chinese", "hamster", "ovary", "cells", "upon", "those", "cells", "the", "ability", "to", "bind", "C1416902#ent", "<e1>", "LPL", ")", "."], "h": {"id": "C2239507", "name": "C2239507#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [28, 29]}}
{"token": ["Some", "proteolytic", "enzymes", ",", "trypsin", ",", "cathepsin", "B", "C1332805#ent", "<e1>", "collagenase", ",", "elastase", "and", "their", "inhibitors", ",", "API", "and", "C1412382#ent", "<e2>", ",", "in", "serum", "of", "patients", "with", "colorectal", "carcinoma", "been", "evaluated", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412382", "name": "C1412382#ent", "pos": [19, 20]}}
{"token": ["This", "strategy", "is", "based", "upon", "tagging", "a", "short", "peptide", "of", "C0815040#ent", "<e1>", "AAA", ")", "to", "N", "terminus", "of", "human", "beta-glucuronidase", "(", "C0795965#ent", "<e2>", ")", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0795965", "name": "C0795965#ent", "pos": [21, 22]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "determine", "if", "nicotinamide", "and", "C0047215#ent", "<e1>", ",", "two", "inhibitors", "of", "the", "C0085748#ent", "<e2>", "could", "modify", "the", "in", "vitro", "toxicity", "of", "chrysotile", "fibers"], "h": {"id": "C0047215", "name": "C0047215#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085748", "name": "C0085748#ent", "pos": [18, 19]}}
{"token": ["A", "high", "correlation", "was", "found", "for", "the", "C1336937#ent", "<e1>", "expression", "level", "with", "the", "histological", "grading", "staging", "scores", "the", "C0669372#ent", "<e2>", "as", "well", "as", "in", "the", "portal", "region"], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "expression", "of", "CD55", "and", "CD59", "by", "C1438155#ent", "<e1>", "and", "PC9", "cells", "was", "decreased", "after", "treatment", "with", "C1538607#ent", "<e2>", ",", "resulting", "in", "increased", "susceptibility", "to", "cH18A-mediated", "CDC", "."], "h": {"id": "C1438155", "name": "C1438155#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538607", "name": "C1538607#ent", "pos": [18, 19]}}
{"token": ["When", "C0042397#ent", "<e1>", "doses", "of", "C1708407#ent", "<e2>", "or", "high", "concentrations", "DDAVP", "were", "infused", ",", "\"", "basal", "\"", "RR", "remained", "unchanged", "."], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1708407", "name": "C1708407#ent", "pos": [5, 6]}}
{"token": ["Older", "age", "male", "sex", ",", "comorbidities", ",", "previous", "hospitalisations", "for", "C1145670#ent", "<e1>", "and", "admission", "to", "a", "ward", "not", "appropriate", "to", "treat", "C0035242#ent", "<e2>", "the", "most", "important", "predictors", "of", "30-day", "mortality", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [21, 22]}}
{"token": ["In", "our", "patient's", ",", "we", "added", "gradual", "blood", "contamination", "explain", "the", "progressive", "development", "of", "C1145670#ent", "<e1>", "the", "severity", "of", "the", "C0035242#ent", "<e2>", "to", "the", "massive", "dose", "injected", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [20, 21]}}
{"token": ["This", "EGF-induced", "RalA", "activation", "was", "not", "observed", "when", "lamellipodial", "protrusion", "suppressed", "by", "a", "dominant", "negative", "mutant", "of", "C1419227#ent", "<e1>", ",", "a", "GTPase-activating", "protein", "Cdc42", ",", "inhibitors", "of", "C0044602#ent", "<e2>", "or", "inhibitors", "of", "actin", "polymerization"], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [27, 28]}}
{"token": ["Further", "refinement", "of", "the", "computational", "model", "C1419227#ent", "<e1>", "regulation", "of", "C0044602#ent", "<e2>", "and", "SHIP2", ",", "which", "was", "also", "validated", "experimentally", "."], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [10, 11]}}
{"token": ["7,12-dimethylbenz(a)anthracene", "(", "DMBA", ")", "and", "benzo(a)", "pyrene", "C1822725#ent", "<e1>", ")", "was", "significantly", "inhibited", "by", "diallylsulfide", "(", "C0057671#ent", "<e2>", ")", "and", "indole-3-carbinol", "(", "I3C", ")", "in", "mouse", "skin"], "h": {"id": "C1822725", "name": "C1822725#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0057671", "name": "C0057671#ent", "pos": [16, 17]}}
{"token": ["In", "presence", "of", "low", "Ca2", "+", "concentration", "(", "0.22", "nM", ")", ",", "the", "potency", "of", "C1963718#ent", "<e1>", "in", "antagonizing", "C1414518#ent", "<e2>", "contractions", "was", "reduced", "in", "about", "2-fold", "."], "h": {"id": "C1963718", "name": "C1963718#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414518", "name": "C1414518#ent", "pos": [19, 20]}}
{"token": ["C1321756#ent", "<e1>", "in", "the", "elderly", "and", "C0270952#ent", "<e2>", "the", "most", "favorable", "outcome", "."], "h": {"id": "C1321756", "name": "C1321756#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270952", "name": "C0270952#ent", "pos": [6, 7]}}
{"token": ["C2931008#ent", "<e1>", "CDGS", ")", "is", "an", "inherited", "C0005944#ent", "<e2>", "multisystemic", "abnormalities", "from", "a", "failure", "to", "add", "entire", "N-linked", "oligosaccharide", "chains", "many", "glycoproteins", "."], "h": {"id": "C2931008", "name": "C2931008#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [7, 8]}}
{"token": ["Hynobius", "P450", "aromatase", "(", "C3254086#ent", "<e1>", ")", "and", "Dmrt-1", "complementary", "C0011522#ent", "<e2>", "were", "isolated", "and", "their", "expression", "patterns", "were", "analyzed", "by", "competitive", "and", "conventional", "reverse", "transcriptase-polymerase", "chain", "reaction"], "h": {"id": "C3254086", "name": "C3254086#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [10, 11]}}
{"token": ["Whereas", "Grx5", "contains", "a", "single", "glutaredoxin", "domain", "in", "C1423888#ent", "<e1>", "and", "Grx4", "a", "C0752501#ent", "<e2>", "fused", "to", "the", "glutaredoxin", "domain"], "h": {"id": "C1423888", "name": "C1423888#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0752501", "name": "C0752501#ent", "pos": [13, 14]}}
{"token": ["The", "new", "reversible", "MAO-A", "inhibitors", "brofaromine", "and", "moclobemide", "were", "compared", "with", "the", "irreversible", "MAOIs", "clorgyline", ",", "C0700467#ent", "<e1>", ",", "phenelzine", "and", "C0040778#ent", "<e2>", "."], "h": {"id": "C0700467", "name": "C0700467#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0040778", "name": "C0040778#ent", "pos": [21, 22]}}
{"token": ["Differentiation", "of", "human", "promyelocytic", "leukemia", "cells", "HL-60", ")", "in", "response", "to", "several", "classes", "of", "inducing", "C0991617#ent", "<e1>", "is", "characterized", "by", "the", "sequential", "appearance", "of", "granulocytic", "or", "C0021345#ent", "<e2>", "markers", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [26, 27]}}
{"token": ["C0393584#ent", "<e1>", "a", "rare", "autosomal", "dominant", "disorder", "with", "a", "childhood-onset", "and", "slowly", "progressive", "C0008489#ent", "<e2>", "."], "h": {"id": "C0393584", "name": "C0393584#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0008489", "name": "C0008489#ent", "pos": [13, 14]}}
{"token": ["These", "C0030956#ent", "<e1>", "and", "related", "C0059961#ent", "<e2>", "were", "isolated", "from", "an", "enzymatic", "digest", "of", "caseins", "by", "chromatographic", "techniques", "gel", "filtration", "hydrophobic", "column", "multiple-step", "high", "pressure", "liquid", "chromatography"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059961", "name": "C0059961#ent", "pos": [5, 6]}}
{"token": ["Clonidine", "'s", "threshold", "(", "greater", "than", "10", "mmHg", ",", "less", "than", "20", "mmHg", ")", "antihypertensive", "effect", "potentiated", "by", "C0031448#ent", "<e1>", "but", "opposed", "by", "C0007680#ent", "<e2>", "antagonists", "as", "was", "the", "maximal", "antihypertensive", "effect"], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0007680", "name": "C0007680#ent", "pos": [23, 24]}}
{"token": ["This", "study", "was", "purposed", "to", "compare", "the", "effects", "of", "isoflurane", "conveyed", "in", "minimal", "flow", "CCA", ")", "and", "in", "high", "flow", "C0018790#ent", "<e1>", ")", "on", "the", "neuromuscular", "blockade", "C0209337#ent", "<e2>", "."], "h": {"id": "C0018790", "name": "C0018790#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0209337", "name": "C0209337#ent", "pos": [27, 28]}}
{"token": ["Here", "we", "introduce", "a", "C1412100#ent", "<e1>", "technique", "with", "rotated", "apertures", "that", "we", "call", "rotating", "aperture", "optimization", "C1412430#ent", "<e2>", ")", "."], "h": {"id": "C1412100", "name": "C1412100#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412430", "name": "C1412430#ent", "pos": [16, 17]}}
{"token": ["The", "recently", "determined", "structure", "of", "octameric", "C0914594#ent", "<e1>", "provided", "new", "insights", "into", "the", "functioning", "of", "this", "C0014442#ent", "<e2>", "and", "its", "role", "in", "channelling", "energy", "from", "the", "mitochondria", "to", "the", "cytoplasm", "."], "h": {"id": "C0914594", "name": "C0914594#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["Octamer", "stability", "and", "membrane", "binding", "C0914594#ent", "<e1>", "MtCK", ")", "are", "important", "for", "proper", "functioning", "of", "the", "C0014442#ent", "<e2>", "and", "were", "suggested", "as", "targets", "for", "regulatory", "mechanisms"], "h": {"id": "C0914594", "name": "C0914594#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["The", "lowest", "ki", "values", "were", "shown", "for", "lactate", "dehydrogenase", "isozyme", "1", "C1705085#ent", "<e1>", "and", "for", "the", "two", "C0026794#ent", "<e2>", "of", "malate", "dehydrogenase"], "h": {"id": "C1705085", "name": "C1705085#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026794", "name": "C0026794#ent", "pos": [17, 18]}}
{"token": ["When", "patients", "treated", "with", "metformin", ",", "sulfonylurea", "(", "SU", ")", ",", "C1257987#ent", "<e1>", "or", "a", "combination", "of", "these", "drugs", "fail", ",", "the", "C1999257#ent", "<e2>", "mimectics", "may", "be", "preferred", "to", "insulin", "treatment"], "h": {"id": "C1257987", "name": "C1257987#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1999257", "name": "C1999257#ent", "pos": [22, 23]}}
{"token": ["C0152025#ent", "<e1>", "has", "been", "implicated", "in", "C0221423#ent", "<e2>", "a", "cause", "of", "difficult", "weaning", "from", "artificial", "ventilation", "of", "rehabilitation", "problems"], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [6, 7]}}
{"token": ["The", "expression", "of", "C1417510#ent", "<e1>", "in", "neutrophils", "and", "monocyte-derived", "macrophages", "mediated", "by", "TLR4", "but", "not", "C1336634#ent", "<e2>", "."], "h": {"id": "C1417510", "name": "C1417510#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336634", "name": "C1336634#ent", "pos": [15, 16]}}
{"token": ["Five", "other", "halogenated", "aromatic", "hydrocarbon", "inducers", "of", "C0010762#ent", "<e1>", "bearing", "steric", "similarity", "C1825776#ent", "<e2>", "(", "including", "2,3,7,8-tetrachlorodibenzo-p-dioxin", ")", ",", "were", "associated", "with", "C0010762#ent", "<e1>", "used", "to", "induce", "C0010762#ent", "<e1>", "rats", "."], "h": {"id": "C1825776", "name": "C1825776#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [7, 8]}}
{"token": ["Although", "C1825776#ent", "<e1>", "induced", "both", "C0010762#ent", "<e2>", "P-450d", ",", "specific", "immunoprecipitation", "of", "these", "isozymes", "from", "HBB-treated", "rats", "showed", "that", "C1825776#ent", "<e1>", "was", "associated", "only", "with", "cytochrome", "P-450d"], "h": {"id": "C1825776", "name": "C1825776#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [5, 6]}}
{"token": ["We", "used", "immunohistological", "analysis", "of", "C0751931#ent", "<e1>", "containing", "sensory", "and", "motor", "fascicles", "stained", "with", ",", "M6749", "and", "anti-neural", "cell", "adhesion", "molecule", "C1334863#ent", "<e2>", ")", "monoclonal", "antibodies"], "h": {"id": "C0751931", "name": "C0751931#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334863", "name": "C1334863#ent", "pos": [21, 22]}}
{"token": ["C0151744#ent", "<e1>", "myocardial", "infarction", "significantly", "related", "to", "presence", "of", "C0085278#ent", "<e2>", "SAPS", ")", ",", "OR", ":", "4.21", ",", "p", "=", "0.008", "and", "OR", ":", "12.8", ";", "p", "=", "0.02", "respectively", ")", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085278", "name": "C0085278#ent", "pos": [9, 10]}}
{"token": ["In", "this", "study", "we", "describe", "a", "series", "of", "nine", "patients", "affected", "by", "acquired", "immunodeficiency", "syndrome", "AIDS", ")", "or", "AIDS-related", "complex", "had", "hypereosinophilia", "and", "C0020455#ent", "<e1>", "hyper-IgE", ")", "with", "chronic", "dermatitis", "recurrent", "C0038160#ent", "<e2>"], "h": {"id": "C0020455", "name": "C0020455#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0038160", "name": "C0038160#ent", "pos": [31, 32]}}
{"token": ["To", "assess", "the", "prevalence", "of", "dyslipidemia", "and", "other", "risk", "factors", "C1956346#ent", "<e1>", "a", "sample", "of", "polio", "survivors", "with", "and", "without", "C0080040#ent", "<e2>"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080040", "name": "C0080040#ent", "pos": [20, 21]}}
{"token": ["The", "C0079429#ent", "<e1>", "responsible", "for", "C1416614#ent", "<e2>", "has", "been", "mapped", "to", "chromosome", "20q", "the", "close", "vicinity", "of", "D20S19", "and", "D20S20", "markers", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416614", "name": "C1416614#ent", "pos": [5, 6]}}
{"token": ["Moreover", ",", "C1566685#ent", "<e1>", "C459S-expressing", "cells", "displayed", "higher", "C3813239#ent", "<e2>", "phosphotyrosine", "content", ",", "suggesting", "that", "C1566685#ent", "<e1>", "regulates", "C3813239#ent", "<e2>", "phosphorylation", "through", "its", "phosphatase", "domain", "which", "confers", "a", "negative", "regulatory", "effect", "NF-kappaB", "activity"], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3813239", "name": "C3813239#ent", "pos": [8, 9]}}
{"token": ["Because", "C1566685#ent", "<e1>", "is", "the", "major", "binding", "partner", "of", "C3813239#ent", "<e2>", ",", "we", "mutated", "its", "binding", "site", "the", "C3813239#ent", "<e2>", "cDNA", "(", "Gab1/DeltaSHP-2", ")", "."], "h": {"id": "C1566685", "name": "C1566685#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3813239", "name": "C3813239#ent", "pos": [9, 10]}}
{"token": ["Lysosomotropic", "agents", ",", "such", "as", "C0008269#ent", "<e1>", "and", "ammonium", "chloride", "that", "inhibit", "antigen", "processing", "impaired", "C0014457#ent", "<e2>", "presentation", "."], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [15, 16]}}
{"token": ["We", "then", "analyzed", "the", "interactions", "of", "tissue", "transglutaminase", "tTGase", ")", ",", "a", "Ca2", "+", "-dependent", "C0014442#ent", "<e1>", ",", "with", "RhoA", "and", "C1419407#ent", "<e2>", "on", "the", "GST-fusion", "protein", "arrays", "with", "the", "SPR", "biosensor", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419407", "name": "C1419407#ent", "pos": [21, 22]}}
{"token": ["The", "examined", "corneas", "included", "two", "cases", "of", "keratoconus", "complicated", "with", "C0013604#ent", "<e1>", "one", "without", "C0013604#ent", "<e1>", "two", "cases", "of", "C0019357#ent", "<e1>", "one", "case", "of", "post-intracapsular", "cataract", "extraction", "post-ICCE", ")", "and", "one", "case", "of", "luetic", "keratitis"], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019357", "name": "C0019357#ent", "pos": [19, 20]}}
{"token": ["Thermophilic", "Campylobacter", "C1875400#ent", "<e1>", "from", "infected", "humans", "from", "the", "southwest", "of", "the", "C1424298#ent", "<e2>", "were", "bio-", "and", "serotyped", "according", "to", "Lior", "'s", "scheme", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424298", "name": "C1424298#ent", "pos": [12, 13]}}
{"token": ["All", "C0014442#ent", "<e1>", "subjected", "to", "C0520739#ent", "<e2>", "as", "described", "above", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0520739", "name": "C0520739#ent", "pos": [5, 6]}}
{"token": ["(4-Hydroxyphenyl)pyruvate", "dioxygenase", "HPPD", ")", "is", "a", "non-heme", "Fe(II", ")", "C0014442#ent", "<e1>", "that", "catalyzes", "the", "conversion", "of", "(4-hydroxyphenyl)pyruvate", "(", "C0520739#ent", "<e2>", ")", "to", "homogentisate", "as", "part", "of", "the", "tyrosine", "catabolism", "pathway"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0520739", "name": "C0520739#ent", "pos": [18, 19]}}
{"token": ["Additionally", ",", "the", "activity", "of", "rhamnose-releasing", "C0014442#ent", "<e1>", "present", "in", "minor", "quantities", "might", "be", "enhanced", "after", "C0520739#ent", "<e2>", ",", "resulting", "in", "a", "decrease", "of", "rhamnose", "in", "the", "polymeric", "cell", "wall", "material", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0520739", "name": "C0520739#ent", "pos": [16, 17]}}
{"token": ["To", "explore", "if", "the", "inhibitory", "effect", "of", "3-n-butylphthalide(NBP", ")", "on", "apoptosis", "induced", "by", "transient", "C0007785#ent", "<e1>", "rats", "is", "relevant", "to", "cortical", "calcineurin", "C0006784#ent", "<e2>", "activities", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [22, 23]}}
{"token": ["Data", "from", "patients", "65", "years", "and", "older", "with", "C0029408#ent", "<e1>", "or", "rheumatoid", "arthritis", "that", "C0059865#ent", "<e2>", "is", "as", "well", "tolerated", "in", "elderly", "as", "in", "younger", "patients", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0059865", "name": "C0059865#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "the", "excess", "mortality", "in", "rheumatoid", "arthritis", "RA", ")", ",", "a", "disease", "characterized", "by", "C0409667#ent", "<e1>", "is", "chiefly", "due", "to", "death", "from", "C0007222#ent", "<e2>", "."], "h": {"id": "C0409667", "name": "C0409667#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [23, 24]}}
{"token": ["Previous", "findings", "have", "shown", "that", "hypotensive", "doses", "C0126174#ent", "<e1>", "prevent", "the", "excess", "of", "apoptosis", "present", "in", "the", "C0149721#ent", "<e2>", "adult", "spontaneously", "hypertensive", "rats", "(", "SHR", ")", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0149721", "name": "C0149721#ent", "pos": [17, 18]}}
{"token": ["The", "mouse", "NTKL", "protein", "is", "highly", "C1512488#ent", "<e1>", "with", "human", "C1422597#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422597", "name": "C1422597#ent", "pos": [10, 11]}}
{"token": ["Ribonuclease", "L", "C0071795#ent", "<e1>", "is", "a", "C1333398#ent", "<e2>", "an", "evolutionarily", "ancient", "interferon-regulated", "dsRNA-activated", "antiviral", "pathway", "."], "h": {"id": "C0071795", "name": "C0071795#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333398", "name": "C1333398#ent", "pos": [6, 7]}}
{"token": ["C0071795#ent", "<e1>", "RNase", "L", "is", "a", "C1333398#ent", "<e2>", "an", "evolutionarily", "ancient", "interferon-regulated", "dsRNA-activated", "antiviral", "pathway", "."], "h": {"id": "C0071795", "name": "C0071795#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333398", "name": "C1333398#ent", "pos": [6, 7]}}
{"token": ["We", "hypothesise", "that", "these", "beneficial", "effects", "of", "the", "C0013227#ent", "<e1>", "may", "be", "because", "of", "the", "negative", "efficacy", "at", "the", "C1704463#ent", "<e2>", ",", "combined", "with", "beta1AR", "antagonism", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704463", "name": "C1704463#ent", "pos": [19, 20]}}
{"token": ["We", "investigated", "C1332680#ent", "<e1>", "production", "and", "the", "inhibitory", "effects", "of", "C3539185#ent", "<e2>", "on", "C1332680#ent", "<e1>", "expression", "in", "a", "murine", "model", "of", "allergic", "asthma"], "h": {"id": "C1332680", "name": "C1332680#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539185", "name": "C3539185#ent", "pos": [10, 11]}}
{"token": ["The", "majority", "of", "oncogenes", "studied", "may", "be", "included", "into", "the", "second", "group", "C-myc", ",", "ras", ",", "sis", ",", "C3853644#ent", "<e1>", ")", "and", "only", "one", "C1706383#ent", "<e2>", "into", "the", "first", "group", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [24, 25]}}
{"token": ["In", "this", "study", "most", "patients", "had", "an", "C3892044#ent", "<e1>", "consistent", "with", "reactive", "arthritis", "a", "septic", "arthritis", "to", "C0018081#ent", "<e2>"], "h": {"id": "C3892044", "name": "C3892044#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018081", "name": "C0018081#ent", "pos": [17, 18]}}
{"token": ["C0031269#ent", "<e1>", "diagnosed", "in", "a", "51-year-old", "woman", "presenting", "with", "C0162316#ent", "<e2>"], "h": {"id": "C0031269", "name": "C0031269#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [9, 10]}}
{"token": ["However", ",", "more", "recently", "PKA-independent", "pathways", "have", "been", "established", "through", "the", "C1538124#ent", "<e1>", "activated", "by", "cAMP", "(", "Epac", ")", ",", "a", "C0120465#ent", "<e2>", "the", "small", "GTPases", "Rap1", "and", "Rap2", "."], "h": {"id": "C1538124", "name": "C1538124#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [21, 22]}}
{"token": ["C1420400#ent", "<e1>", "ternary", "complex", "formation", "by", "C1335590#ent", "<e2>", "is", "stimulated", "by", "ERK", "phosphorylation", "but", "not", "by", "SAPK/JNKs", "."], "h": {"id": "C1420400", "name": "C1420400#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335590", "name": "C1335590#ent", "pos": [6, 7]}}
{"token": ["C0591224#ent", "<e1>", "and", "renitek", "exhibited", "in", "57", "patients", "with", "C2364010#ent", "<e2>", "only", "a", "hypotensive", "effect", ",", "but", "also", "reduced", "intraglomerular", "hypertension", "and", "proteinuria", "."], "h": {"id": "C0591224", "name": "C0591224#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2364010", "name": "C2364010#ent", "pos": [9, 10]}}
{"token": ["The", "patients", "were", "heterogeneous", "for", "the", "genetic", "defect", "C1334332#ent", "<e1>", "activity", "was", "absent", "in", "five", "patients", "(", "C1855498#ent", "<e2>", "but", "normal", "in", "two", "."], "h": {"id": "C1334332", "name": "C1334332#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1855498", "name": "C1855498#ent", "pos": [17, 18]}}
{"token": ["In", "a", "patient", "with", "both", "lichen", "planus", "C1419789#ent", "<e1>", ",", "and", "suffering", "from", "C0085293#ent", "<e2>", "we", "examined", "the", "T", "cell", "receptor", "TCR", ")", "Vb", "repertoire", "by", "reverse", "transcriptase", "polymerase", "chain", "reaction", "skin", "lesions", "C1419789#ent", "<e1>", "and", "lichen", "planus"], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085293", "name": "C0085293#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "unlike", "in", "yeast", ",", "in", "Drosophila", "individual", "C3541903#ent", "<e1>", "interact", "with", "multiple", "kinases", "that", "individual", "NDR", "C0031727#ent", "<e2>", "interact", "with", "multiple", "C3541903#ent", "<e1>"], "h": {"id": "C3541903", "name": "C3541903#ent", "pos": [10, 11]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}}
{"token": ["We", "constructed", "a", "recombinant", "adenovirus", "expressing", "p53", "and", "then", "delivered", "this", "into", "cervical", "carcinoma", "cell", "lines", "CaSki", ",", "SiHa", ",", "and", "HeLa", ",", "C3812156#ent", "<e1>", ")", "along", "with", "adenovirus", "expressing", "C0005220#ent", "<e2>", "as", "a", "negative", "control"], "h": {"id": "C3812156", "name": "C3812156#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [30, 31]}}
{"token": ["However", ",", "C0001962#ent", "<e1>", "on", "the", "threshold", "of", "making", "a", "C0017547#ent", "<e2>", "leap", "forward", "in", "our", "understanding", "the", "etiology", "of", "alcoholism", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [10, 11]}}
{"token": ["Also", ",", "such", "great", "quantities", "of", "C0001962#ent", "<e1>", "were", "consistently", "consumed", "by", "this", "C0017547#ent", "<e2>", "of", "a", "man", "at", "6", "ft", "8", "in", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "there", "is", "a", "biological", "difference", "physiological", "and", "pathological", "angiogenesis", ",", "C1336602#ent", "<e1>", "having", "a", "physiological", "role", "and", "C3541334#ent", "<e2>", "being", "involved", "in", "pathological", "angiogenesis", "."], "h": {"id": "C1336602", "name": "C1336602#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3541334", "name": "C3541334#ent", "pos": [21, 22]}}
{"token": ["C2347126#ent", "<e1>", ",", "structurally", "a", "C3536710#ent", "<e2>", ",", "has", "complex", "steroid", "hormone", "effects", "predicted", "by", "its", "interaction", "with", "progesterone", ",", "androgen", "and", "glucocorticoid", "receptors"], "h": {"id": "C2347126", "name": "C2347126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536710", "name": "C3536710#ent", "pos": [5, 6]}}
{"token": ["The", "contrasting", "effects", "of", "progesterone", "and", "C2347126#ent", "<e1>", "seem", "clinically", "important", ",", "inasmuch", "as", "C2347126#ent", "<e1>", "is", "a", "widely", "used", "C3536710#ent", "<e1>", "in", "the", "regimen", "of", "hormone", "replacement", "therapy"], "h": {"id": "C2347126", "name": "C2347126#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536710", "name": "C3536710#ent", "pos": [20, 21]}}
{"token": ["The", "SRP", "tablet", "showed", "sustained", "release", "and", "slow", "absorption", ";", "and", "it", "had", "an", "improved", "C0003158#ent", "<e1>", "efficacy", "against", "Clonorchis", "sinensis", "experimental", "dogs", "compared", "with", "conventional", "C0032911#ent", "<e2>", "."], "h": {"id": "C0003158", "name": "C0003158#ent", "pos": [15, 16]}, "relation": "therapeutic_class_of", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [26, 27]}}
{"token": ["A", "new", "combination", "of", "two", "C0003158#ent", "<e1>", "emodepside", "and", "C0032911#ent", "<e2>", "(", "Profender", ",", "Bayer", "AG", ",", "Levekusen", ",", "Germany", ")", "was", "tested", "in", "pet", "rodents", "reptiles", "."], "h": {"id": "C0003158", "name": "C0003158#ent", "pos": [5, 6]}, "relation": "therapeutic_class_of", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [9, 10]}}
{"token": ["In", "comparison", "with", "C0700478#ent", "<e1>", ",", "both", "tropisetron", "and", "C0543476#ent", "<e2>", "proved", "to", "be", "more", "effective", "after", "ASCT", ",", "when", "emetogenic", "factors", "than", "chemotherapy", "alone", "participated", "."], "h": {"id": "C0700478", "name": "C0700478#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0543476", "name": "C0543476#ent", "pos": [9, 10]}}
{"token": ["MAPK", "kinase", "inhibitor", "C0755562#ent", "<e1>", ")", "and", "staurosporine", "reduced", "calcitriol-mediated", "betaTC(3", ")", "death", ",", "and", "down-regulation", "of", "C0812327#ent", "<e2>", "prevented", "by", "staurosporine", "but", "not", "C0755562#ent", "<e1>", "."], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [3, 4]}}
{"token": ["Likewise", ",", "C0724725#ent", "<e1>", "clearance", "was", "higher", "and", "half-life", "shorter", "in", "women", "using", "C1282359#ent", "<e2>", "but", "differences", "were", "not", "significant", "."], "h": {"id": "C0724725", "name": "C0724725#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1282359", "name": "C1282359#ent", "pos": [13, 14]}}
{"token": ["Unlike", "IL-1beta", ",", "NS-398", "and", "C1367472#ent", "<e1>", "did", "not", "cause", "C1417708#ent", "<e2>", "nuclear", "translocation", "nor", "did", "they", "further", "enhance", "IL-1beta-induced", "NF-kappaB", "translocation", ",", "but", "they", "stimulated", "PPARgamma", "translocation", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "central", "C1572795#ent", "<e1>", "administration", "significantly", "reduced", "the", "expression", "of", "the", "proinflammatory", "enzymes", "C1565860#ent", "<e2>", "and", "inducible", "nitric-oxide", "synthase", "and", "it", "significantly", "restored", "carrageenan-induced", "PPAR-alpha", "reduction", "in", "the", "spinal", "cord"], "h": {"id": "C1572795", "name": "C1572795#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [14, 15]}}
{"token": ["C0105523#ent", "<e1>", "or", "amlodipine", "significantly", "increased", "C3540613#ent", "<e2>", "levels", "(", "P", "<", "0.05", "vs.", "untreated", "ischemia", ")", ",", "but", "only", "benazepril", "significantly", "increased", "cGMP", "(", "P", "<", "0.05", ")", "."], "h": {"id": "C0105523", "name": "C0105523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540613", "name": "C3540613#ent", "pos": [6, 7]}}
{"token": ["In", "this", "study", ",", "we", "examined", "the", "effects", "of", "C1367472#ent", "<e1>", "on", "D-galactosamine", "(GalN)/lipopolysaccharide", "(LPS)-induced", "fulminant", "C0085605#ent", "<e2>", "mice", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [16, 17]}}
{"token": ["CGBG", "is", "a", "homodimer", "of", "two", "26-kDa", "subunits", "forming", "disulfide", "bonds", "since", "HDMA", "labeling", "of", "a", "protein", "of", "53", "kDa", "was", "observed", "in", "SDS-polyacrylamide", "gel", "electrophoresis", "C0010648#ent", "<e1>", "was", "absent", "during", "C0272170#ent", "<e2>", "denaturation", "."], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [31, 32]}}
{"token": ["C0010648#ent", "<e1>", "stimulated", "the", "activity", "only", "in", "the", "presence", "of", "C0272170#ent", "<e2>", "."], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [10, 11]}}
{"token": ["The", "relative", "activity", "of", "these", "enzymes", "on", "C0038317#ent", "<e1>", "unknown", "due", "to", "variable", "levels", "of", "C3538711#ent", "<e2>", "expression", "in", "different", "in", "vitro", "cell", "line", "models", "various", "conditions", "of", "the", "enzymatic", "assays"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3538711", "name": "C3538711#ent", "pos": [15, 16]}}
{"token": ["The", "C0178472#ent", "<e1>", "albizziin", "was", "used", "to", "isolate", "Chinese", "hamster", "ovary", "cell", "lines", "overproduce", "C1412588#ent", "<e2>"], "h": {"id": "C0178472", "name": "C0178472#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412588", "name": "C1412588#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", ",", "we", "describe", "two", "new", "C1707196#ent", "<e1>", "coding", "changes", "CYP2C8*2", "an", "Ile269Phe", "substitution", "in", "exon", "5", "C1707190#ent", "<e2>", "both", "Arg139Lys", "and", "Lys399Arg", "amino", "acid", "substitutions", "in", "exons", "3", "8", "."], "h": {"id": "C1707196", "name": "C1707196#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1707190", "name": "C1707190#ent", "pos": [19, 20]}}
{"token": ["The", "signaling", "pathway", "is", "initiated", "by", "binding", "of", "C1414313#ent", "<e1>", "EGFR", ")", "and", "results", "in", "sustained", "signaling", "through", "C1709402#ent", "<e2>", "an", "important", "role", "in", "a", "tumor", "'s", "response", "to", "ionizing", "radiation"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [18, 19]}}
{"token": ["Cell", "signaling", "at", "the", "C1414313#ent", "<e1>", "EGFR", ")", ",", "RAS", "oncoproteins", ",", "or", "C1709402#ent", "<e2>", "to", "a", "common", "pathway", "that", "promotes", "tumor", "survival", "radiation-induced", "DNA", "damage"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [13, 14]}}
{"token": ["ORF2", "is", "C1439333#ent", "<e1>", ",", "encoding", "uridine", "5'-diphosphogalactose", "4-epimerase", "and", "ORF4", "is", "adk", ",", "encoding", "C1412305#ent", "<e2>"], "h": {"id": "C1439333", "name": "C1439333#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412305", "name": "C1412305#ent", "pos": [15, 16]}}
{"token": ["C1414557#ent", "<e1>", ",", "a", "nonclassical", "MHC-I", "protein", "bound", "to", "C1412709#ent", "<e2>", "beta", "2", "m", ")", ",", "diverts", "IgG", "and", "albumin", "from", "an", "intracellular", "degradative", "fate", "prolonging", "the", "half-lives", "of", "both", "."], "h": {"id": "C1414557", "name": "C1414557#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412709", "name": "C1412709#ent", "pos": [9, 10]}}
{"token": ["C1415014#ent", "<e1>", "activates", "both", "PAR1", "and", "C1539608#ent", "<e2>", ",", "whereas", "hK2", "activates", "C1539608#ent", "<e2>", "."], "h": {"id": "C1415014", "name": "C1415014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539608", "name": "C1539608#ent", "pos": [6, 7]}}
{"token": ["These", "data", "indicate", "that", "prostatic", "kallikreins", "hK2", "and", "C1415014#ent", "<e1>", ")", "directly", "stimulate", "prostate", "cancer", "cell", "proliferation", "PAR1", "and/or", "C1539608#ent", "<e2>", "and", "may", "be", "potentially", "important", "targets", "for", "future", "drug", "therapy", "prostate", "cancer"], "h": {"id": "C1415014", "name": "C1415014#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539608", "name": "C1539608#ent", "pos": [19, 20]}}
{"token": ["C0038761#ent", "<e1>", "synthesized", ";", "these", "are", "analogues", "of", "C0010980#ent", "<e2>", "(", "DDS", ")", "but", "contain", ",", "instead", "of", "one", "benzene", "nucleus", "a", "heterocycle", "that", "is", "a", "pyrimidine", ",", "pyrazine", "or", "pyridazine", "nucleus", "."], "h": {"id": "C0038761", "name": "C0038761#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "suggest", "that", "RB1CC1", "insufficiency", "may", "result", "in", "C1307407#ent", "<e1>", "signaling", "repression", "through", "unbalanced", "C0694894#ent", "<e2>", "abundance", "and", "may", "induce", "neuronal", "atrophy"], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0694894", "name": "C0694894#ent", "pos": [15, 16]}}
{"token": ["Tubers", "likely", "form", "by", "constitutive", "activation", "of", "the", "C1307407#ent", "<e1>", "cascade", "during", "brain", "development", "a", "consequence", "of", "impaired", "C0694894#ent", "<e2>", "or", "tuberin", "function"], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0694894", "name": "C0694894#ent", "pos": [18, 19]}}
{"token": ["Phorbol", "12,13-dibutyrate", "a", "C0033634#ent", "<e1>", "PKC", ")", "activator", ",", "and", "permeable", "c-AMP", "derivatives", "which", "activate", "C0010531#ent", "<e2>", "PKA", ")", ",", "stimulated", "phosphorylation", "of", "K-ras(4B", ")", "p21", "in", "416B", "cells", "3", "to", "5", "fold", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [15, 16]}}
{"token": ["The", "C-terminal", "peptide", "a", "more", "specific", "substrate", "for", "C0033634#ent", "<e1>", "whereas", "histoneH", "1", "is", "a", "substrate", "for", "C0010531#ent", "<e2>", "well", "protein", "kinase", "With", "both", "substrates", "the", "enzyme", "activity", "increases", "after", "induction", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [17, 18]}}
{"token": ["We", "further", "established", "that", "the", "transition", "proteins", "in", "vitro", "substrates", "for", "the", "C0033634#ent", "<e1>", "PKC", ")", "as", "well", "as", "the", "C0010531#ent", "<e2>", "PKA", ")", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [20, 21]}}
{"token": ["In", "some", "cases", "an", "increasing", "C0020473#ent", "<e1>", "was", "the", "first", "indication", "of", "impending", "'", "propofol", "C0039082#ent", "<e2>", "onset", "and", "it", "should", "not", "be", "viewed", "as", "a", "benign", "sign", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [15, 16]}}
{"token": ["C0268494#ent", "<e1>", "was", "observed", "for", "dogs", "given", "only", "C0065571#ent", "<e2>", "single", "oral", "dosages", ">", "or", "=", "9", "mg/kg", "."], "h": {"id": "C0268494", "name": "C0268494#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0065571", "name": "C0065571#ent", "pos": [8, 9]}}
{"token": ["From", "these", "QTLs", ",", "we", "identified", "a", "number", "of", "candidate", "genes", "within", "the", "C0597336#ent", "<e1>", "intervals", "that", "include", "C1420316#ent", "<e2>", "containing", "gene", ",", "nebulin-related", "anchoring", "protein", "and", "actin-binding", "LIM", "protein", "1"], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420316", "name": "C1420316#ent", "pos": [18, 19]}}
{"token": ["TAK1", "(", "TGF-beta", "activated", "C0031727#ent", "<e1>", "is", "one", "of", "the", "C1367798#ent", "<e2>", "MAPKKK", ")", "that", "is", "involved", "in", "TGF-beta", "signal", "transduction"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1367798", "name": "C1367798#ent", "pos": [10, 11]}}
{"token": ["Two", "tumours", "expressed", "C3274609#ent", "<e1>", "fusion", "transcripts", "involving", "EWS", "exon", "7", "C0599295#ent", "<e2>", "exon", "6"], "h": {"id": "C3274609", "name": "C3274609#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [11, 12]}}
{"token": ["In", "developing", "countries", ",", "severe", "and", "moderately", "severe", "C0019069#ent", "<e1>", "may", "be", "at", "a", "higher", "risk", "of", "C0451641#ent", "<e2>", "because", "of", "prolonged", "recumbency", "necessitated", "by", "recurrent", "joint", "bleeds", "inadequate", "replacement", "therapy"], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [17, 18]}}
{"token": ["Respiratory", "failure", "for", "the", "majority", "of", "deaths", "in", "C0002736#ent", "<e1>", "C1704945#ent", "<e2>", ")", "but", "only", "rarely", "is", "C1704945#ent", "<e2>", "diagnosed", "on", "the", "basis", "of", "respiratory", "insufficiency"], "h": {"id": "C0002736", "name": "C0002736#ent", "pos": [8, 9]}, "relation": "disease_has_associated_gene", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [10, 11]}}
{"token": ["Titres", "of", "antiphosphatidyl", "serine", "PS", ")", "(", "p", "less", "than", "0.005", ")", "and", "PEA", "antibodies", "p", "less", "than", "0.05", ")", "were", "significantly", "higher", "in", "the", "C0039128#ent", "<e1>", "to", "the", "C0024141#ent", "<e2>", "sera", "."], "h": {"id": "C0039128", "name": "C0039128#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [29, 30]}}
{"token": ["Patients", "with", "AMA-M5", "displayed", "a", "higher", "prevalence", "of", "thrombocytopenia", ",", "thrombosis", ",", "biological", "false", "positive", "for", "C0039128#ent", "<e1>", ",", "lupus-like", "anticoagulant", "activity", "anti-cardiolipin", "antibodies", "comparison", "with", "a", "group", "of", "43", "C0024141#ent", "<e2>", "AMA-M5", "negative", "patients", "."], "h": {"id": "C0039128", "name": "C0039128#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [30, 31]}}
{"token": ["The", "naturally", "occurring", "somatostatins", "SRIF-28", ",", "C1710000#ent", "<e1>", ",", "and", "SRIF-14", "all", "reveal", "C1721278#ent", "<e2>", "sst1.5", "."], "h": {"id": "C1710000", "name": "C1710000#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1721278", "name": "C1721278#ent", "pos": [13, 14]}}
{"token": ["Using", "these", "DNase", "footprints", "we", "built", "a", "computational", "model", "the", "C1538957#ent", "<e1>", "DNA-binding", "module", "which", "was", "used", "to", "identify", "in", "silico", "potential", "C0035680#ent", "<e2>", "target", "genes", "in", "the", "human", "and", "mouse", "promoter", "databases"], "h": {"id": "C1538957", "name": "C1538957#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035680", "name": "C0035680#ent", "pos": [22, 23]}}
{"token": ["Notable", "differences", "between", "CCLs", "and", "C0007286#ent", "<e1>", "were", "observed", "in", "matrix", "metalloproteinases", "plasminogen", "activator", "collagens", ",", "C1419150#ent", "<e2>", ",", "and", "thrombospondin", "2", "etc", ".", ","], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419150", "name": "C1419150#ent", "pos": [16, 17]}}
{"token": ["Based", "on", "these", "observations", ",", "we", "propose", "that", "C1333928#ent", "<e1>", ",", "under", "stress", "conditions", ",", "favors", "the", "degradation", "of", "C1956096#ent", "<e2>", "such", "as", "phosphorylated", "I-kappaBalpha"], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1956096", "name": "C1956096#ent", "pos": [19, 20]}}
{"token": ["Standard", "solubilization", "buffer", "yielded", "poorly", "resolved", "protein", "spots", "but", "pre-treatment", "of", "cells", "with", "C0040900#ent", "<e1>", "inclusion", "of", "the", "protease", "inhibitor", "C0040495#ent", "<e2>", "during", "solubilization", "improved", "definition", "and", "separation", "."], "h": {"id": "C0040900", "name": "C0040900#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040495", "name": "C0040495#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "using", "EPO-deficient", "mice", "and", "an", "EPO", "inhibitor", "resorcinol", "we", "demonstrate", "that", "C0059409#ent", "<e1>", "critical", "in", "the", "development", "of", "GI", "dysfunction", "experimental", "C0009324#ent", "<e2>", "."], "h": {"id": "C0059409", "name": "C0059409#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [23, 24]}}
{"token": ["C1842577#ent", "<e1>", "a", "congenital", "brain", "malformation", "the", "cerebellar", "vermis", "brainstem", "with", "abnormalities", "of", "axonal", "decussation", "C0014877#ent", "<e2>", "in", "the", "brain", ")", "affecting", "the", "corticospinal", "tract", "superior", "cerebellar", "peduncles"], "h": {"id": "C1842577", "name": "C1842577#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0014877", "name": "C0014877#ent", "pos": [15, 16]}}
{"token": ["To", "compare", "the", "pattern", "of", "localised", "nerve", "fibre", "layer", "C1417668#ent", "<e1>", ")", "defects", "in", "C0152136#ent", "<e2>", "NTG", ")", "and", "primary", "open", "angle", "glaucoma", "POAG", ")", "."], "h": {"id": "C1417668", "name": "C1417668#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0152136", "name": "C0152136#ent", "pos": [14, 15]}}
{"token": ["We", "present", "one", "case", "of", "C0343190#ent", "<e1>", "Pneumocystis", "carinii", "pneumonia", "after", "longterm", "C0699320#ent", "<e2>", "and", "corticosteroid", "treatment", "."], "h": {"id": "C0343190", "name": "C0343190#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0699320", "name": "C0699320#ent", "pos": [12, 13]}}
{"token": ["This", "shows", "that", "the", "copy", "number", "C1336656#ent", "<e1>", ",", "like", "that", "of", "other", "C1458146#ent", "<e2>", ",", "may", "vary", "between", "eukaryotes", "."], "h": {"id": "C1336656", "name": "C1336656#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [13, 14]}}
{"token": ["When", "a", "second", "functional", "copy", "of", "the", "C1336656#ent", "<e1>", "introduced", "into", "the", "genome", ",", "the", "C1458146#ent", "<e2>", "be", "readily", "disrupted", "by", "homologous", "recombination", "at", "7", "%", "efficiency", ")", "."], "h": {"id": "C1336656", "name": "C1336656#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [15, 16]}}
{"token": ["The", "angiotensin", "converting", "enzyme", "(ACE)", "inhibitors", "enalapril", ",", "C0072970#ent", "<e1>", ",", "cilazapril", "and", "C0072857#ent", "<e2>", "are", "prodrugs", "that", "are", "rapidly", "converted", "to", "active", "metabolites", "which", "are", "excreted", "unchanged", "through", "the", "kidneys", "."], "h": {"id": "C0072970", "name": "C0072970#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0072857", "name": "C0072857#ent", "pos": [13, 14]}}
{"token": ["A", "need", "for", "prompt", "investigation", "is", "emphasised", "by", "the", "potentially", "rapid", "progression", "and", "poor", "prognosis", "some", "bacterial", "and", "C0026946#ent", "<e1>", "and", "the", "public", "health", "of", "C0747256#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [25, 26]}}
{"token": ["To", "estimate", "the", "risk", "of", "C0030567#ent", "<e1>", "PD", ")", "in", "individuals", "with", "mutations", "in", "the", "C1418270#ent", "<e2>"], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [15, 16]}}
{"token": ["X-linked", "recessive", "nephrolithiasis", "C0403720#ent", "<e1>", ")", "was", "described", "in", "a", "large", "kindred", "in", "which", "C0392525#ent", "<e2>", ";", "proximal", "tubular", "dysfunction", "proteinuria", ",", "nephrocalcinosis", ",", "and", "renal", "failure", "only", "in", "males", "."], "h": {"id": "C0403720", "name": "C0403720#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [14, 15]}}
{"token": ["The", "deletion", "of", "C1970187#ent", "<e1>", "be", "responsible", "for", "C1858160#ent", "<e2>", "."], "h": {"id": "C1970187", "name": "C1970187#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1858160", "name": "C1858160#ent", "pos": [8, 9]}}
{"token": ["Several", "studies", "indicate", "that", "C0030940#ent", "<e1>", "can", "also", "regulate", "C1335877#ent", "<e2>", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335877", "name": "C1335877#ent", "pos": [9, 10]}}
{"token": ["In", "these", "vessels", ",", "C1420727#ent", "<e1>", "traverses", "the", "endothelium", "at", "isolated", ",", "C0015230#ent", "<e2>", "rather", "than", "uniformly", ",", "for", "short", "circulation", "."], "h": {"id": "C1420727", "name": "C1420727#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [12, 13]}}
{"token": ["Platelets", "exhibited", "predominantly", "heparanase", "activity", "whereas", "the", "EC", "degradation", "products", "suggested", "a", "range", "of", "enzymic", "activities", ",", "namely", "C0030940#ent", "<e1>", ",", "heparanases", "and", "C1426909#ent", "<e2>", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1426909", "name": "C1426909#ent", "pos": [23, 24]}}
{"token": ["Allopurinol", "and", "C0030086#ent", "<e1>", ",", "but", "not", "superoxide", "dismutase", "C0007367#ent", "<e2>", ",", "protected", "the", "gastric", "mucosa", "h", "after", "endothelin-1", "injection", "."], "h": {"id": "C0030086", "name": "C0030086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "the", "role", "of", "endogenous", "GABA", "on", "C3273356#ent", "<e1>", "biosynthesis", "in", "vivo", "GABA", "levels", "were", "raised", "by", "using", "the", "C0002543#ent", "<e2>", "GABA", "and", "ethanolamine-O-sulfate", "."], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002543", "name": "C0002543#ent", "pos": [20, 21]}}
{"token": ["The", "application", "of", "HSC", "transplantation", "been", "expanded", "over", "the", "past", "decade", "to", "include", "immune-mediated", "diseases", "as", "C1417325#ent", "<e1>", "treatment-refractory", "rheumatoid", "arthritis", ",", "systemic", "lupus", "erythematosus", "C1290138#ent", "<e2>"], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [25, 26]}}
{"token": ["C3266102#ent", "<e1>", "NS", ")", "with", "focal", "glomerulosclerosis", "C0220769#ent", "<e2>", ")", "and", "its", "recurrence", "after", "transplantation", "are", "mainly", "seen", "in", "children", "."], "h": {"id": "C3266102", "name": "C3266102#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0220769", "name": "C0220769#ent", "pos": [7, 8]}}
{"token": ["Analysis", "of", "two", "XP-V", "cell", "lines", ",", "defective", "in", "C0675096#ent", "<e1>", "showed", "bypass", "of", "89", "%", ",", "indicating", "that", "C1335439#ent", "<e2>", "not", "essential", "for", "bypass", "of", "abasic", "sites"], "h": {"id": "C0675096", "name": "C0675096#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [19, 20]}}
{"token": ["Type", "2", "3alpha-HSD", "cloned", "from", "human", "prostate", ",", "is", "a", "member", "of", "the", "C1412327#ent", "<e1>", "AKR", ")", "superfamily", "and", "was", "named", "C1412326#ent", "<e2>", "."], "h": {"id": "C1412327", "name": "C1412327#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412326", "name": "C1412326#ent", "pos": [21, 22]}}
{"token": ["Thus", "activation", "of", "the", "C1420232#ent", "<e1>", "exchanger", "by", "either", "C0304512#ent", "<e2>", "vasoactive", "peptides", "on", "the", "mobilization", "of", "intracellular", "Ca2", "+", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0304512", "name": "C0304512#ent", "pos": [9, 10]}}
{"token": ["2", "patients", "showed", "C1258215#ent", "<e1>", "due", "to", "C4082764#ent", "<e2>", "necessity", "of", "operation", "."], "h": {"id": "C1258215", "name": "C1258215#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4082764", "name": "C4082764#ent", "pos": [7, 8]}}
{"token": ["C0011854#ent", "<e1>", "frequently", "is", "the", "consequence", "of", "C1257763#ent", "<e2>", "causing", "overweight", ",", "which", "then", "produces", "insulin", "resistance"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1257763", "name": "C1257763#ent", "pos": [7, 8]}}
{"token": ["The", "'", "thrifty", "phenotype", "'", "hypothesis", "states", "that", "impaired", "glucose", "tolerance", "IGT", ")", "and", "C0011854#ent", "<e1>", "NIDDM", ")", "are", "the", "result", "of", "adaptation", "to", "C1257763#ent", "<e2>", "in", "the", "fetal", "and", "infant", "environment", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1257763", "name": "C1257763#ent", "pos": [24, 25]}}
{"token": ["The", "heat", "shock", "treatment", "significantly", "repressed", "the", "induction", "of", "C1456357#ent", "<e1>", "activity", "and", "C0359916#ent", "<e2>", "accumulation", "in", "cut", "lettuce", "storage", ",", "and", "prevented", "the", "browning", "of", "cut", "lettuce"], "h": {"id": "C1456357", "name": "C1456357#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0359916", "name": "C0359916#ent", "pos": [13, 14]}}
{"token": ["Interestingly", ",", "three", "autosomal", "recessive", "disorders", "been", "associated", "with", "mutations", "in", "the", "RECQL4", "gene", "Rothmund-Thomson", ",", "RAPADILINO", ",", "and", "C0265308#ent", "<e1>", "thus", "making", "C1335607#ent", "<e2>", "unique", "within", "the", "RecQ", "family", "DNA", "helicases"], "h": {"id": "C0265308", "name": "C0265308#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1335607", "name": "C1335607#ent", "pos": [23, 24]}}
{"token": ["Our", "results", "confirm", "that", "C0265308#ent", "<e1>", "in", "a", "subgroup", "of", "patients", "is", "due", "to", "C1335607#ent", "<e2>", "mutations", "and", "could", "be", "integrated", "into", "a", "clinical", "spectrum", "encompasses", "RTS", "and", "RAPADILINO", "syndrome", "."], "h": {"id": "C0265308", "name": "C0265308#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335607", "name": "C1335607#ent", "pos": [14, 15]}}
{"token": ["This", "retrospective", "study", "the", "long", "term", "efficacy", "of", "pars", "plana", "vitrectomy", "the", "preservation", "of", "vision", "in", "complicated", "C0042164#ent", "<e1>", "including", "endogenous", "C0042166#ent", "<e2>", "other", "entities", "."], "h": {"id": "C0042164", "name": "C0042164#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0042166", "name": "C0042166#ent", "pos": [21, 22]}}
{"token": ["Most", "cases", "of", "C0042164#ent", "<e1>", "idiopathic", "and", "show", "the", "signs", "of", "a", "C0042166#ent", "<e2>"], "h": {"id": "C0042164", "name": "C0042164#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0042166", "name": "C0042166#ent", "pos": [12, 13]}}
{"token": ["Some", "models", ",", "such", "as", "those", "of", "arthritis", ",", "C0024138#ent", "<e1>", ",", "diabetes", ",", "thyroiditis", "and", "C0014038#ent", "<e2>", ",", "are", "discussed", "."], "h": {"id": "C0024138", "name": "C0024138#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [16, 17]}}
{"token": ["To", "study", "the", "roles", "of", "fibronectin", "(", "C1706331#ent", "<e1>", ")", "played", "in", "rat", "C0034069#ent", "<e2>"], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [13, 14]}}
{"token": ["One", "of", "the", "main", "targets", "of", "child", "epileptology", "is", "ADEE", ",", "i.e.", "the", "West", "and", "C0238111#ent", "<e1>", "addition", "to", "C3463992#ent", "<e2>", "suppression-burst", "(", "EIEE", ")", "."], "h": {"id": "C0238111", "name": "C0238111#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3463992", "name": "C3463992#ent", "pos": [19, 20]}}
{"token": ["Modulation", "in", "the", "expression", "of", "the", "C3539658#ent", "<e1>", "has", "a", "profound", "effect", "on", "C1417487#ent", "<e2>", "susceptibility", "and", "this", "effect", "was", "found", "to", "be", "dependent", "on", "the", "folate", "concentration", "of", "the", "medium", "."], "h": {"id": "C3539658", "name": "C3539658#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [13, 14]}}
{"token": ["Current", "treatment", "of", "acute", "organophosphate", "(", ")", "poisoning", "includes", "a", "combined", "administration", "of", "a", "cholinesterase", "reactivator", "oxime", ")", ",", "a", "muscarinic", "receptor", "antagonist", "C1161352#ent", "<e1>", ")", "and", "an", "C0003286#ent", "<e2>", "(", "diazepam", ")", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [28, 29]}}
{"token": ["administration", "of", "a", "cholinesterase", "reactivator", "an", "oxime", ")", ",", "a", "muscarinic", "cholinergic", "receptor", "antagonist", "C1161352#ent", "<e1>", ")", "and", "a", "C0003286#ent", "<e2>", "diazepam", ")", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [19, 20]}}
{"token": ["Their", "relative", "clearance", "rates", ",", "being", "rapid", "for", "the", "bone", "C1424288#ent", "<e1>", ",", "significantly", "slower", "for", "the", "liver", "C0597298#ent", "<e2>", "and", "very", "slow", "for", "the", "placental", "C1424288#ent", "<e1>", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1424288", "name": "C1424288#ent", "pos": [10, 11]}}
{"token": ["Recent", "studies", "have", "shown", "C0717550#ent", "<e1>", "to", "be", "an", "effective", "therapy", "for", "C0018801#ent", "<e2>", "patients", ",", "producing", "a", "significant", "reduction", "in", "mortality", "and", "morbidity", "."], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}}
{"token": ["Although", "C0002697#ent", "<e1>", "produces", "acute", "hemodynamic", "improvement", "in", "patients", "with", "severe", "chronic", "congestive", "heart", "failure", "C0018802#ent", "<e2>", ")", ",", "it", "has", "not", "produced", "clinical", "benefits", "long-term", "controlled", "trials"], "h": {"id": "C0002697", "name": "C0002697#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["C0002697#ent", "<e1>", "was", "given", "to", "14", "patients", "with", "C0018802#ent", "<e2>", "an", "intravenous", "bolus", "1", "mg/sec", ")", "at", "doses", "ranging", "from", "0.5", "to", "3.5", "mg/kg", "."], "h": {"id": "C0002697", "name": "C0002697#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}}
{"token": ["The", "fact", "that", "the", "drug", "is", "orally", "active", "makes", "C0002697#ent", "<e1>", "a", "v", ":", "ry", "promising", "inotropic", "agent", "the", "treatment", "of", "C0018802#ent", "<e2>", "man", "."], "h": {"id": "C0002697", "name": "C0002697#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [21, 22]}}
{"token": ["Since", "C0006230#ent", "<e1>", ",", "another", "ergot", "alkaloid", "also", "enhances", "guanylate", "cyclase", "activity", "it", "appears", "that", "C3541393#ent", "<e2>", "a", "common", "mechanism", "of", "action", "which", "involves", "the", "guanylate", "cyclase-cyclic", "GMP", "system", "at", "the", "cellular", "level"], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3541393", "name": "C3541393#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", "the", "ability", "of", "C0006230#ent", "<e1>", "and", "several", "other", "C3541393#ent", "<e2>", "release", "[3H]dopamine", "from", "isolated", "nerve", "endings", "was", "demonstrated", "using", "in", "vitro", "superfusion", "of", "rat", "striatal", "synaptosomes", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541393", "name": "C3541393#ent", "pos": [11, 12]}}
{"token": ["Taken", "together", ",", "we", "investigate", "the", "novel", "cytoprotective", "effect", "C0006230#ent", "<e1>", "involving", "PI3K-", "and", "Nrf2-mediated", "upregulation", "of", "the", "C1424792#ent", "<e2>", "NQO1", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1424792", "name": "C1424792#ent", "pos": [18, 19]}}
{"token": ["These", "observations", "can", "be", "interpreted", "in", "terms", "of", "a", "model", "for", "two", "interconvertible", "forms", "of", "the", "C1413400#ent", "<e1>", "favored", "by", "C0243192#ent", "<e2>", "and", "antagonists", "."], "h": {"id": "C1413400", "name": "C1413400#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [20, 21]}}
{"token": ["C0085114#ent", "<e1>", "is", "highly", "C1512488#ent", "<e2>", "to", "the", "ERM", "(", "ezrin-radixin-moesin", ")", "family", "of", "membrane/cytoskeleton", "linker", "proteins"], "h": {"id": "C0085114", "name": "C0085114#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [4, 5]}}
{"token": ["Changes", "in", "lens", "C2744579#ent", "<e1>", "levels", "at", "longer", "periods", "of", "C0475718#ent", "<e2>", "(", "6", "-", "8", "weeks", ")", "have", "been", "reported", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0475718", "name": "C0475718#ent", "pos": [10, 11]}}
{"token": ["Injections", "of", "C0004259#ent", "<e1>", "in", "monkeys", "had", "no", "effect", "C1433276#ent", "<e2>", "for", "valid", "or", "invalid", "trials", "significantly", "slowed", "C1433276#ent", "<e2>", "in", "double-cue", "trials", "that", "did", "not", "require", "the", "orienting", "of", "attention", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1433276", "name": "C1433276#ent", "pos": [9, 10]}}
{"token": ["Further", "analyses", "suggested", "that", "the", "modification", "of", "C0008546#ent", "<e1>", "within", "the", "C1332416#ent", "<e2>", "promoter", "could", "be", "a", "molecular", "explanation", "silencing", "of", "survivin", "gene", "transcription", "p53", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [11, 12]}}
{"token": ["In", "the", "latter", "phenotype", "the", "spindle", "structures", "a", "decrease", "pole-to-pole", "length", "a", "reduction", "of", "MTs", "around", "the", "C0008546#ent", "<e1>", "indicating", "that", "C1332416#ent", "<e2>", "may", "promote", "the", "stabilization", "of", "MT-chromatin", "interactions", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [21, 22]}}
{"token": ["C1539977#ent", "<e1>", "is", "a", "C0021699#ent", "<e2>", "for", "osteoclast", "precursor", "fusion"], "h": {"id": "C1539977", "name": "C1539977#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [4, 5]}}
{"token": ["We", "identified", "the", "C1539977#ent", "<e1>", "DC-STAMP", ",", "a", "putative", "seven", "C0021699#ent", "<e2>", "and", "generated", "DC-STAMP-deficient", "mice", "."], "h": {"id": "C1539977", "name": "C1539977#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [10, 11]}}
{"token": ["The", "C1704661#ent", "<e1>", "polymorphism", "was", "determined", "by", "polymerase", "chain", "reaction", "the", "ATG", "and", "C1427398#ent", "<e2>", "polymorphisms", "were", "determined", "by", "single-step", "LightCycler", "technology", "."], "h": {"id": "C1704661", "name": "C1704661#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1427398", "name": "C1427398#ent", "pos": [13, 14]}}
{"token": ["Sex", "steroids", "the", "following", "markers", "of", "bone", "remodeling", "measured", ":", "serum", "osteocalcin", "OC", ")", ",", "procollagen", "I", "carboxyterminal", "extension", "peptide", "C0312399#ent", "<e1>", "BAP", ")", "and", "urinary", "crosslinks", "CTX", "and", "C0285526#ent", "<e2>", ")", "."], "h": {"id": "C0312399", "name": "C0312399#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0285526", "name": "C0285526#ent", "pos": [29, 30]}}
{"token": ["On", "the", "other", "hand", ",", "the", "cellular", "retention", "observed", "for", "C0393754#ent", "<e1>", "was", "much", "longer", "than", "for", "C1539312#ent", "<e2>", ",", "indicating", "a", "strong", "trapping", "of", "C0393754#ent", "<e1>", "in", "cells", "."], "h": {"id": "C0393754", "name": "C0393754#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [17, 18]}}
{"token": ["In", "the", "epithelium", ",", "levels", "of", "10B", "were", "appreciably", "lower", "after", "the", "administration", "of", "C0393754#ent", "<e1>", "than", "was", "the", "case", "after", "C1539312#ent", "<e2>", "."], "h": {"id": "C0393754", "name": "C0393754#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [21, 22]}}
{"token": ["Evaluation", "of", "tongue", "mucosal", "response", "(", "ulceration", ")", "to", "BNC", "irradiation", "indicated", "a", "considerably", "reduced", "radiation", "sensitivity", "C0393754#ent", "<e1>", "as", "the", "boron", "delivery", "agent", "relative", "to", "C1539312#ent", "<e2>", "."], "h": {"id": "C0393754", "name": "C0393754#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [26, 27]}}
{"token": ["Eighty-three", "percent", "fulfilled", "the", "1982", "revised", "criteria", "when", "C0003864#ent", "<e1>", "was", "strictly", "defined", "(", "C3898123#ent", "<e2>", "and", "91", "%", "when", "C0003864#ent", "<e1>", "was", "more", "liberally", "defined", "(", "nondeforming", "C0003864#ent", "<e1>", ")", "."], "h": {"id": "C3898123", "name": "C3898123#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [8, 9]}}
{"token": ["Incontinentia", "pigmenti", "C0021171#ent", "<e1>", ")", "is", "a", "C0019247#ent", "<e2>", "is", "usually", "lethal", "in", "males", "."], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}}
{"token": ["These", "include", "reduction", "in", "Ca2", "+", "influx", "and", "extracellular", "signal-regulated", "kinase", "1/2", "phosphorylation", ",", "leading", "to", "a", "decrease", "in", "C1413235#ent", "<e1>", "expression", ",", "proliferation", ",", "and", "C1522405#ent", "<e2>", "production", "."], "h": {"id": "C1413235", "name": "C1413235#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [26, 27]}}
{"token": ["The", "first", "symptom", "of", "scleroderma", "is", "often", "C0034734#ent", "<e1>", "phenomenon", ",", "which", "is", "associated", "with", "diffuse", "C0042373#ent", "<e2>", "ischemia", "and", "reperfusion", "injury", "skin", "and", "other", "organs", "targeted", "in", "this", "disease", "."], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [16, 17]}}
{"token": ["Most", "reports", "suggesting", "a", "link", "between", "C4021534#ent", "<e1>", "SNHL", ")", "and", "this", "C0013227#ent", "<e2>", "have", "been", "in", "association", "with", "prolonged", "doses", "for", "treatment", "of", "Mycobacterium", "lung", "disease"], "h": {"id": "C4021534", "name": "C4021534#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["In", "pNR-MG1", ",", "transcription", "of", "the", "C0027260#ent", "<e1>", "driven", "from", "its", "endogenous", "promoter", ",", "and", "the", "C1366752#ent", "<e2>", "transcribed", "from", "an", "SV40", "viral", "promoter", "as", "in", "pSV2neo", "."], "h": {"id": "C0027260", "name": "C0027260#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366752", "name": "C1366752#ent", "pos": [16, 17]}}
{"token": ["As", "shown", "in", "the", "corneal", "tissue", "sections", "and", "in", "the", "epithelial", "and", "endothelial", "cell", ",", "a", "bright", "fluorescence", "the", "endothelial", "cell", "membranes", "observed", "in", "C0003742#ent", "<e1>", "incubated", "in", "10(-5)-10(-3", ")", "mol/l", "C0029904#ent", "<e2>", "."], "h": {"id": "C0003742", "name": "C0003742#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [31, 32]}}
{"token": ["Detection", "of", "loricrin", ",", "involucrin", ",", "and", "C1416714#ent", "<e1>", "reduced", "in", "HPV", "59-infected", "epithelium", ",", "while", "small", "proline-rich", "protein", "3", "C1335267#ent", "<e2>", ")", "was", "increased", "."], "h": {"id": "C1416714", "name": "C1416714#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335267", "name": "C1335267#ent", "pos": [20, 21]}}
{"token": ["The", "effect", "of", "C1705556#ent", "<e1>", "was", "coupled", "to", "phospholipase", "C", "C2987155#ent", "<e2>", ")", "activity", "because", "the", "C2987155#ent", "<e2>", "inhibitor", "U-73122", "eliminated", "the", "effects", "of", "C1705556#ent", "<e1>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [10, 11]}}
{"token": ["This", "study", "describes", "the", "anti-nicotinic", "properties", "of", "the", "clinically", "used", "anticholinergic", "antiparkinson", "drugs", "benztropine", ",", "biperiden", ",", "C0054635#ent", "<e1>", ",", "ethopropazine", ",", "procyclidine", "and", "C0041009#ent", "<e2>", "."], "h": {"id": "C0054635", "name": "C0054635#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0041009", "name": "C0041009#ent", "pos": [24, 25]}}
{"token": ["Of", "the", "mothers", ",", "eight", "had", "C3541883#ent", "<e1>", "reactivity", ",", "10", "showed", "a", "response", "to", "the", "C1416925#ent", "<e2>", "antigen", "and", "seven", "to", "the", "pp150", "antigen", "."], "h": {"id": "C3541883", "name": "C3541883#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416925", "name": "C1416925#ent", "pos": [16, 17]}}
{"token": ["All", "neonates", "showed", "a", "response", "to", "C3541883#ent", "<e1>", ",", "an", "assembly", "protein", "nine", "responded", "to", "the", "C1416925#ent", "<e2>", "immediate", "early", "antigen", "but", "only", "four", "had", "reactivity", "to", "the", "pp150", "tegument", "associated", "protein", "."], "h": {"id": "C3541883", "name": "C3541883#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416925", "name": "C1416925#ent", "pos": [16, 17]}}
{"token": ["Pharmacologic", "trials", "demonstrated", "that", "some", "C0006287#ent", "<e1>", "patients", "have", "good", "therapeutic", "response", "antipsychotics", "and", "C0040778#ent", "<e2>", "and", "poor", "response", "alprazolam", "."], "h": {"id": "C0006287", "name": "C0006287#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040778", "name": "C0040778#ent", "pos": [14, 15]}}
{"token": ["To", "report", "a", "patient", "with", "C0039263#ent", "<e1>", "severe", "proliferative", "retinopathy", "to", "C0271217#ent", "<e2>"], "h": {"id": "C0039263", "name": "C0039263#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0271217", "name": "C0271217#ent", "pos": [11, 12]}}
{"token": ["The", "group", "of", "C0040615#ent", "<e1>", "users", "(", "including", "bipolar", "disorder", "patients", ")", "showed", "significantly", "higher", "C1450094#ent", "<e2>", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1450094", "name": "C1450094#ent", "pos": [15, 16]}}
{"token": ["However", ",", "there", "was", "no", "correlation", "between", "the", "cumulative", "life-time", "C0040615#ent", "<e1>", "usage", "and", "C1450094#ent", "<e2>", "levels", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1450094", "name": "C1450094#ent", "pos": [14, 15]}}
{"token": ["C1850168#ent", "<e1>", "characterized", "by", "the", "association", "of", "C0003886#ent", "<e2>", "and", "osteogenesis", "imperfecta", "."], "h": {"id": "C1850168", "name": "C1850168#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003886", "name": "C0003886#ent", "pos": [7, 8]}}
{"token": ["Juvenile", "systemic", "sclerosis", "C2931591#ent", "<e1>", ")", "is", "a", "rare", "form", "of", "C1290138#ent", "<e2>", "also", "known", "as", "scleroderma", ")", "."], "h": {"id": "C2931591", "name": "C2931591#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [11, 12]}}
{"token": ["The", "enzymes", "were", "C1450094#ent", "<e1>", "L-lactate", "oxidase", ",", "and", "C0112125#ent", "<e2>", "all", "three", "of", "which", "interact", "with", "pyruvate", ",", "as", "well", "as", "cyclohexanone", "monooxygenase", "2-methyl-3-hydroxypyridine-5-carboxylic", "acid", "oxygenase", "which", "were", "both", "probed", "with", "nicotinamide", "nucleotides"], "h": {"id": "C1450094", "name": "C1450094#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0112125", "name": "C0112125#ent", "pos": [9, 10]}}
{"token": ["Neuregulin", "is", "reported", "to", "stimulate", "synapse-specific", "transcription", "of", "acetylcholine", "receptor", "AChR", ")", "C1417679#ent", "<e1>", "in", "the", "skeletal", "muscle", "fiber", "by", "multiple", "signaling", "pathways", "as", "ERK", ",", "C1709402#ent", "<e2>", "and", "JNK", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [26, 27]}}
{"token": ["In", "an", "effort", "to", "identify", "C1417679#ent", "<e1>", "whose", "expression", "is", "regulated", "by", "activated", "phosphatidylinositol", "3-kinase", "C1709402#ent", "<e2>", "signaling", ",", "we", "performed", "microarray", "analysis", "subsequent", "quantitative", "reverse", "transcription-PCR", "an", "isogenic", "set", "PTEN", "gene-targeted", "human", "cancer", "cells", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [15, 16]}}
{"token": ["Radiation", "treatment", "followed", "by", "C2681322#ent", "<e1>", ",", "COAP", "or", "CAMP", "polychemotherapy", "to", "curb", "C0007774#ent", "<e2>", "progression", "."], "h": {"id": "C2681322", "name": "C2681322#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007774", "name": "C0007774#ent", "pos": [13, 14]}}
{"token": ["C0520680#ent", "<e1>", "SDB", ")", "is", "common", "in", "C0264716#ent", "<e2>", "CHF", ")", ",", "affects", "disease", "progression", "presents", "a", "potential", "therapeutic", "target", "."], "h": {"id": "C0520680", "name": "C0520680#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0264716", "name": "C0264716#ent", "pos": [7, 8]}}
{"token": ["The", "cholangiocarcinomas", "associated", "with", "C1623038#ent", "<e1>", "and", "the", "cholangiocarcinoma", "elements", "of", "combined", "hepatocellular-cholangiocellular", "carcinoma", "expressed", "MUC3", "and", "C2983560#ent", "<e2>", ",", "but", "the", "cholangiocarcinomas", "not", "associated", "with", "C1623038#ent", "<e1>", "frequently", "expressed", "these", "apomucins", "."], "h": {"id": "C2983560", "name": "C2983560#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [4, 5]}}
{"token": ["In", "terms", "of", "metabolism", ",", "C0009079#ent", "<e1>", "is", "primarily", "metabolized", "by", "C1620185#ent", "<e2>", ",", "which", "biotransforms", "C0009079#ent", "<e1>", "to", "norclozapine", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [11, 12]}}
{"token": ["Different", "covariates", "(", "age", ",", "body", "weight", "height", ",", "C1620185#ent", "<e1>", "daily", "dose", "C0009079#ent", "<e2>", ")", "were", "tested", "but", "C1620185#ent", "<e1>", "the", "single", "parameter", "that", "improved", "significantly", "the", "predictive", "model", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [13, 14]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [9, 10]}}
{"token": ["Other", "streptococcal", "and", "C0038160#ent", "<e1>", "exhibit", "overlapping", "clinical", "features", ",", "including", "scarlet", "fever", "C0021099#ent", "<e2>", ",", "toxic", "shock", "syndrome", "and", "cellulitis", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0021099", "name": "C0021099#ent", "pos": [13, 14]}}
{"token": ["Likewise", ",", "cell", "proliferation", "which", "is", "controlled", "by", "C1413043#ent", "<e1>", "+", ",", "was", "reduced", "in", "C2987026#ent", "<e2>", "and", "PKD1-LCLs", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987026", "name": "C2987026#ent", "pos": [15, 16]}}
{"token": ["C1422666#ent", "<e1>", "is", "highly", "related", "to", "C0812287#ent", "<e2>", "downstream-regulated", "protein", "1", "which", "has", "been", "linked", "to", "stress", "responses", "cell", "proliferation", "and", "differentiation", ",", "although", "C1422666#ent", "<e1>", "itself", "is", "not", "repressed", "by", "C0812287#ent", "<e2>", "."], "h": {"id": "C1422666", "name": "C1422666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812287", "name": "C0812287#ent", "pos": [6, 7]}}
{"token": ["C1422666#ent", "<e1>", ",", "a", "new", "member", "of", "the", "C0812287#ent", "<e2>", "downstream-regulated", "gene", "NDRG", ")", "family", ",", "is", "a", "focus", "for", "study", "at", "present", "."], "h": {"id": "C1422666", "name": "C1422666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812287", "name": "C0812287#ent", "pos": [8, 9]}}
{"token": ["The", "organic", "molecule", "C0124355#ent", "<e1>", "promoted", "cell", "survival", "neurite", "outgrowth", "and", "increased", "C0008407#ent", "<e2>", "ChAT", ")", "activity", "in", "rat", "embryonic", "striatal", "and", "basal", "forebrain", "cultures", "in", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0124355", "name": "C0124355#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008407", "name": "C0008407#ent", "pos": [12, 13]}}
{"token": ["We", "also", "tested", "the", "influence", "C0129791#ent", "<e1>", "on", "the", "vasodilator", "responses", "acetylcholine", "(", "ACh", ")", "and", "C0885378#ent", "<e2>", "(", "GTN", ")", "during", "elevated", "pulmonary", "arterial", "tone", "."], "h": {"id": "C0129791", "name": "C0129791#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0885378", "name": "C0885378#ent", "pos": [16, 17]}}
{"token": ["The", "results", "of", "this", "study", "indicate", "that", "C0076840#ent", "<e1>", "is", "suitable", "for", "the", "treatment", "of", "sodium", "retention", "patients", "with", "C0023890#ent", "<e2>", "and", "ascites", "."], "h": {"id": "C0076840", "name": "C0076840#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [19, 20]}}
{"token": ["A", "greater", "than", "normal", "fraction", "of", "C0076840#ent", "<e1>", "was", "recovered", "in", "the", "urine", "of", "patients", "with", "C0023890#ent", "<e2>", "."], "h": {"id": "C0076840", "name": "C0076840#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [16, 17]}}
{"token": ["Microinjection", "of", "a", "C0907533#ent", "<e1>", "active", "mutant", "of", "C0919338#ent", "<e2>", "induced", "process", "formation", "suggesting", "that", "C0919338#ent", "<e2>", "indeed", "involved", "in", "the", "neurite", "outgrowth"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0919338", "name": "C0919338#ent", "pos": [8, 9]}}
{"token": ["In", "group", "III", "C1537501#ent", "<e1>", "was", "infused", "in", "the", "presence", "of", "propranolol", ",", "a", "C0001644#ent", "<e2>", "to", "prevent", "any", "permeability-decreasing", "effects", "of", "beta-adrenergic", "activation"], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [14, 15]}}
{"token": ["The", "C1417679#ent", "<e1>", "encoding", "for", "the", "light", "and", "C4285649#ent", "<e2>", "cloned", "by", "RT-PCR", "from", "a", "murine", "monoclonal", "hybridoma", "cell", "line", "which", "could", "produce", "monoclonal", "antibody", "recognize", "CD19", "antigen", "human", "B", "lymphocyte"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4285649", "name": "C4285649#ent", "pos": [8, 9]}}
{"token": ["Three", "different", "gene", "loci", "for", "pure", "autosomal", "dominant", "C1705593#ent", "<e1>", "and", "1", "for", "pure", "autosomal", "C0017361#ent", "<e2>", "C1705593#ent", "<e1>", "recently", "have", "been", "found", "."], "h": {"id": "C1705593", "name": "C1705593#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [15, 16]}}
{"token": ["Severe", "caries", "causing", "early", "loss", "of", "permanent", "teeth", "the", "only", "C1457887#ent", "<e1>", "could", "be", "attributed", "to", "C0020630#ent", "<e2>", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020630", "name": "C0020630#ent", "pos": [16, 17]}}
{"token": ["Treating", "cells", "with", "C0221018#ent", "<e1>", "triggered", "reduction", "of", "kinetochore-bound", "C1333212#ent", "<e2>", "as", "well", "as", "global", "Nek2", "protein", "level", ",", "consequently", "leading", "to", "metaphase", "chromosome", ",", "spindle", "aberrancy", ",", "and", "eventual", "cell", "death"], "h": {"id": "C0221018", "name": "C0221018#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333212", "name": "C1333212#ent", "pos": [9, 10]}}
{"token": ["CTX-M-27", "differed", "from", "CTX-M-14", "only", "by", "the", "substitution", "D240", "G", "and", "was", "the", "third", "CTX-M", "C0014442#ent", "<e1>", "harbouring", "this", "mutation", "after", "CTX-M-15", "and", "C1097461#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1097461", "name": "C1097461#ent", "pos": [23, 24]}}
{"token": ["Among", "platelet", "receptors", "glycoprotein", "(", "GP", ")", "Ib/IX/V", "complex", "is", "peculiar", ",", "as", "it", "binds", "adhesive", "proteins", "mainly", "von", "Willebrand", "factor", "C1336938#ent", "<e1>", ")", ",", "and", "thrombin", ",", "the", "main", "C2987634#ent", "<e2>"], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [30, 31]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "prognostic", "value", "circulating", "secretory", "phospholipase", "A2", "C1418616#ent", "<e1>", ")", "activity", "in", "patients", "with", "C0948089#ent", "<e2>", "ACS", ")", "."], "h": {"id": "C1418616", "name": "C1418616#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0948089", "name": "C0948089#ent", "pos": [22, 23]}}
{"token": ["C2936882#ent", "<e1>", "may", "also", "upregulate", "protein", "levels", "anti-apoptotic", "C0376515#ent", "<e2>", "and", "may", "attenuate", "the", "post-traumatic", "influx", "Ca(2+)"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [8, 9]}}
{"token": ["While", "C0042523#ent", "<e1>", "activated", "the", "C1706373#ent", "<e2>", ",", "the", "cyclosporin", "derivatives", "inhibited", "both", "the", "substrate-stimulated", "and", "the", "basal", "P-glycoprotein", "ATPase"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [5, 6]}}
{"token": ["The", "effects", "of", "these", "steroids", "on", "verapamil-stimulated", "P-gp", "ATPase", "activity", "support", "a", "non-competitive", "mechanism", ",", "i.e.", "the", "binding", "sites", "C0042523#ent", "<e1>", "and", "steroids", "are", "mutually", "non-exclusive", "for", "P-gp", "C1706373#ent", "<e2>", "modulation", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [28, 29]}}
{"token": ["A", "second", "MoAb", "(", "528", ")", "binds", "to", "the", "C2350558#ent", "<e1>", "EGFR", "and", "is", "revealed", "with", "C0031468#ent", "<e2>", "by", "a", "peroxidase-linked", "goat", "antimouse", "IgG2a", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031468", "name": "C0031468#ent", "pos": [16, 17]}}
{"token": ["C1456393#ent", "<e1>", ",", "a", "more", "widely", "distributed", "C0597298#ent", "<e2>", ",", "did", "not", "mediate", "these", "effects", "."], "h": {"id": "C1456393", "name": "C1456393#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [7, 8]}}
{"token": ["Recently", ",", "the", "loss", "of", "C0390769#ent", "<e1>", "C1335842#ent", "<e2>", ")", "gene", "expression", "by", "C1335842#ent", "<e2>", "promoter", "methylation", "was", "identified", "in", "colon", "cancers"], "h": {"id": "C0390769", "name": "C0390769#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335842", "name": "C1335842#ent", "pos": [7, 8]}}
{"token": ["The", "type", "II", "fatty", "acid", "synthases", "FASs", ")", "of", "higher", "plants", "(", "and", "Escherichia", "coli", "contain", "three", "C0008855#ent", "<e1>", "beta-ketoacyl-ACP", "synthases", "KAS", ")", ",", "where", "C0010575#ent", "<e2>", "is", "acyl-carrier-protein", "."], "h": {"id": "C0008855", "name": "C0008855#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010575", "name": "C0010575#ent", "pos": [25, 26]}}
{"token": ["To", "examine", "the", "risk", "of", "C0018790#ent", "<e1>", "vigorous", "exercise", ",", "we", "interviewed", "the", "wives", "of", "133", "men", "without", "known", "prior", "C0018799#ent", "<e2>", "had", "had", "C0018790#ent", "<e1>"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [20, 21]}, "relation": "related_to", "t": {"id": "C0018790", "name": "C0018790#ent", "pos": [5, 6]}}
{"token": ["Colocalization", "studies", "using", "triple-labeling", "immunofluorescence", "microscopy", "showed", "that", "C1959603#ent", "<e1>", "and", "cPLA2-alpha", "are", "coexpressed", "with", "C1565860#ent", "<e2>", "in", "discrete", "populations", "of", "CD14-positive", "synovial", "macrophages", "synovial", "tissue", "fibroblasts", "from", "RA", "patients", "."], "h": {"id": "C1959603", "name": "C1959603#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [15, 16]}}
{"token": ["C1959603#ent", "<e1>", "also", "enhanced", "interleukin", "1-stimulated", "expression", "of", "C1565860#ent", "<e2>", "and", "microsomal", "prostaglandin", "E", "synthase"], "h": {"id": "C1959603", "name": "C1959603#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [8, 9]}}
{"token": ["Nevertheless", ",", "basic", "antiinflammatory", "factors", "as", "C0004057#ent", "<e1>", ",", "and", "other", "COX", "inhibitors", "all", "act", "somehow", "as", "good", "C0033613#ent", "<e2>", "but", "not", "as", "therapeutic", "agents"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033613", "name": "C0033613#ent", "pos": [18, 19]}}
{"token": ["There", "are", "two", "polymorphic", "genes", "NAT1", "and", "C1421999#ent", "<e1>", ")", "encoded", "with", "a", "third", "pseudogene", "C0473780#ent", "<e2>", ")", "at", "human", "8p21.3", "."], "h": {"id": "C1421999", "name": "C1421999#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0473780", "name": "C0473780#ent", "pos": [15, 16]}}
{"token": ["As", "expected", ",", "monooxygenases", "were", "depressed", "by", "IFN", "gamma", "P", "<", "0.05", ")", "and", "C1416602#ent", "<e1>", ",", "the", "ethylresorufin", "O-deethylase", "the", "most", "susceptible", "C0014442#ent", "<e2>", "."], "h": {"id": "C1416602", "name": "C1416602#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [23, 24]}}
{"token": ["While", "treated", "animals", "had", "significantly", "reduced", "microsomal", "protein", "content", ",", "C1416602#ent", "<e1>", "pretreatment", "failed", "to", "alter", "the", "C0014442#ent", "<e2>", "activities", "measured", "."], "h": {"id": "C1416602", "name": "C1416602#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Eighteen", "healthy", "subjects", "doses", "of", "30", "U/kg", ",", "60", "U/kg", ",", "and", "100", "U/kg", "C0015520#ent", "<e1>", "aXa", ")", "of", "C0297269#ent", "<e2>", "by", "subcutaneous", "injection", "."], "h": {"id": "C0015520", "name": "C0015520#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0297269", "name": "C0297269#ent", "pos": [19, 20]}}
{"token": ["More", "distant", "members", "C1418885#ent", "<e1>", "POP", ";", "post", "proline", "cleaving", "enzyme", "and", "acylaminoacylpeptidase", "(", "C1418648#ent", "<e2>", ";", "acylpeptide", "hydrolase", "."], "h": {"id": "C1418885", "name": "C1418885#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418648", "name": "C1418648#ent", "pos": [14, 15]}}
{"token": ["The", "skin", "lesions", "are", "represented", "by", "the", "interface", "dermatitis", "discoid", "lupus", "erythematosus", "DLE", ")", ",", "C0024137#ent", "<e1>", "SCLE", ")", ",", "and", "C0024140#ent", "<e2>"], "h": {"id": "C0024137", "name": "C0024137#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0024140", "name": "C0024140#ent", "pos": [21, 22]}}
{"token": ["This", "C0751039#ent", "<e1>", "variability", "is", "significantly", "larger", "than", "derived", "previously", "for", "C0035542#ent", "<e2>", "Kroenke", ",", "et", "al.", "J.", "Am", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [11, 12]}}
{"token": ["EICs", "of", "trimethoprim", ",", "erythromycin", ",", "C0027396#ent", "<e1>", ",", "ibuprofen", ",", "and", "C0012091#ent", "<e2>", "in", "sewage", "equaled", "or", "exceeded", "the", "US", "FDA", "action", "limit", "of", "1mug/L", "for", "detailed", "environmental", "risk", "assessment", "ERA", ")", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [12, 13]}}
{"token": ["Acidic", "pharmaceuticals", "ibuprofen", ",", "C0027396#ent", "<e1>", ",", "mefenamic", "acid", "ketoprofen", ",", "and", "C0012091#ent", "<e2>", ")", ",", "caffeine", ",", "and", "the", "antibacterial", "triclosan", "quantified", "at", "four", "different", "steps", "of", "wastewater", "treatment", "from", "three", "urban", "wastewater", "treatment", "plants"], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [12, 13]}}
{"token": ["Our", "study", "demonstrates", "that", "C2697954#ent", "<e1>", "hyperphosphorylation", "is", "strongly", "induced", "after", "C0007785#ent", "<e2>", "and", "that", "E2", "inhibits", "C2697954#ent", "<e1>", "hyperphosphorylation", "by", "suppressing", "activation", "of", "the", "JNK/c-Jun/Dkk1", "signaling", "pathway", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2697954", "name": "C2697954#ent", "pos": [4, 5]}}
{"token": ["Congestive", "heart", "failure", "C0019099#ent", "<e1>", ")", "induces", "a", "state", "of", "immune", "activation", "and", "peritoneal", "macrophages", "C2975867#ent", "<e2>", ")", "may", "play", "an", "important", "role", "in", "the", "development", "and", "progression", "of", "one", "such", "condition", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2975867", "name": "C2975867#ent", "pos": [15, 16]}}
{"token": ["Genetic", "defects", "these", "steps", "are", "defined", "as", "cbl", "complementation", "groups", "of", "which", "cblC", ",", "cblD", "(", "described", "in", "only", "two", "siblings", ")", ",", "and", "C1848578#ent", "<e1>", "are", "associated", "with", "homocystinuria", "and", "C1855119#ent", "<e2>"], "h": {"id": "C1848578", "name": "C1848578#ent", "pos": [24, 25]}, "relation": "has_manifestation", "t": {"id": "C1855119", "name": "C1855119#ent", "pos": [31, 32]}}
{"token": ["The", "full-length", "C1336624#ent", "<e1>", "cDNA", "1813", "bp", "contains", "an", "C1412821#ent", "<e2>", "ORF", ")", "of", "1512", "bp", "encoding", "a", "TGFBR1", "protein", "503", "amino", "acids", "a", "calculated", "molecular", "weight", "Mw", ")", "of", "56.4", "kDa", "."], "h": {"id": "C1336624", "name": "C1336624#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [9, 10]}}
{"token": ["Hepatitis", "C", "virus", "HCV", ")", "is", "both", "the", "leading", "cause", "of", "cirrhosis", "and", "C0162557#ent", "<e1>", "to", "liver", "transplantation", "a", "cause", "of", "C0524909#ent", "<e2>", "approximately", "10", "%", "of", "all", "transplant", "recipients", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "we", "report", "that", "the", "tyrosine", "kinase", "Janus", "kinase", "2", "C0169661#ent", "<e1>", ")", ",", "associates", "with", "the", "C1335550#ent", "<e2>", "PP2A", ")", "in", "32Dcl3", "myeloid", "progenitor", "cells", "."], "h": {"id": "C0169661", "name": "C0169661#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335550", "name": "C1335550#ent", "pos": [20, 21]}}
{"token": ["C1333935#ent", "<e1>", "also", "induced", "expression", "of", "C1539081#ent", "<e2>", "a", "B16F10", "cell", "line", ",", "whereas", "LPS", "failed", "to", "do", "so", "."], "h": {"id": "C1333935", "name": "C1333935#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539081", "name": "C1539081#ent", "pos": [6, 7]}}
{"token": ["N-Acetylglucosaminyltransferase", "V", "C3543839#ent", "<e1>", "is", "a", "C1333828#ent", "<e2>", "which", "transfers", "N-acetylglucosamine", "in", "beta(1,6", ")", "linkage", "to", "the", "alpha(1,6)-linked", "mannose", "residue", "of", "Asn-linked", "oligosaccharides"], "h": {"id": "C3543839", "name": "C3543839#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [6, 7]}}
{"token": ["We", "have", "characterized", "a", "C0030956#ent", "<e1>", "from", "the", "GSK-3", "interaction", "domain", "C1332125#ent", "<e2>", "that", "potently", "inhibits", "GSK-3", "activity", "in", "vitro", "in", "mammalian", "cells", "robustly", "activates", "Wnt-dependent", "transcription", ",", "mimicking", "lithium", "action"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332125", "name": "C1332125#ent", "pos": [11, 12]}}
{"token": ["Despite", "relatively", "mild", "lung", "injury", "intratracheal", "TNF-alpha-treated", "TRAF1-/-", "mice", "exhibited", "marked", "liver", "injury", "an", "approximate", "fivefold", "increase", "in", "serum", "C0443764#ent", "<e1>", "levels", "as", "compared", "to", "C2987364#ent", "<e2>", "mice", "."], "h": {"id": "C0443764", "name": "C0443764#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [25, 26]}}
{"token": ["C0053091#ent", "<e1>", ",", "enalapril", ",", "imidapril", "and", "C0072973#ent", "<e2>", "are", "approved", "for", "dogs", "with", "chronic", "heart", "failure", "CHF", ")", "."], "h": {"id": "C0053091", "name": "C0053091#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072973", "name": "C0072973#ent", "pos": [7, 8]}}
{"token": ["PBMC", "from", "C2986600#ent", "<e1>", "patients", "expressed", "similar", "or", "higher", "levels", "of", "C1704873#ent", "<e2>", ",", "LRP", "and", "cMOAT", "mRNAs", ",", "as", "compared", "with", "normal", "PBMC", "."], "h": {"id": "C2986600", "name": "C2986600#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704873", "name": "C1704873#ent", "pos": [11, 12]}}
{"token": ["C0041044#ent", "<e1>", "showed", "greater", "in", "vitro", "inhibition", "and", "earlier", "eradication", "from", "the", "C0021831#ent", "<e2>", "is", "recommended", "as", "a", "suitable", "vibriocidal", "agent", "against", "cholera", "."], "h": {"id": "C0041044", "name": "C0041044#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [12, 13]}}
{"token": ["We", "demonstrate", "that", "C1420712#ent", "<e1>", "interacts", "with", "the", "corepressor", "carboxyl", "terminus-binding", "protein", "(", "C1332799#ent", "<e2>", ")", "via", "this", "motif", "."], "h": {"id": "C1420712", "name": "C1420712#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332799", "name": "C1332799#ent", "pos": [13, 14]}}
{"token": ["Human", "immunodeficiency", "virus/acquired", "immunodeficiency", "syndrome", "C2963174#ent", "<e1>", ")", "has", "resulted", "in", "a", "resurgence", "of", "C0041330#ent", "<e2>", "South", "Africa", "and", "these", "patients", "often", "present", "to", "general", "surgeons"], "h": {"id": "C2963174", "name": "C2963174#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041330", "name": "C0041330#ent", "pos": [14, 15]}}
{"token": ["Analysis", "of", "available", "gene", "sequences", "that", "C0036725#ent", "<e1>", "one", "of", "the", "most", "highly", "conserved", "C0086376#ent", "<e2>", "."], "h": {"id": "C0036725", "name": "C0036725#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}}
{"token": ["The", "day", "after", "discontinuation", "of", "the", "C2911818#ent", "<e1>", "had", "a", "severe", "C0426970#ent", "<e2>", "with", "areflexia", ",", "but", "normal", "head", "movements"], "h": {"id": "C2911818", "name": "C2911818#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0426970", "name": "C0426970#ent", "pos": [11, 12]}}
{"token": ["The", "amino", "acid", "sequence", "by", "the", "cDNA", "for", "C0062539#ent", "<e1>", "shows", "a", "high", "degree", "of", "identity", "to", "pancreatic", "trypsin", "other", "C2717971#ent", "<e2>", "in", "plasma", "."], "h": {"id": "C0062539", "name": "C0062539#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [20, 21]}}
{"token": ["In", "an", "open", ",", "randomized", ",", "parallel", "group", "study", "8", "weeks", ",", "nine", "males", "and", "nine", "females", "with", "C0018801#ent", "<e1>", "initially", "treated", "daily", "20", "mg", "frusemide/2.5", "mg", "C0002502#ent", "<e2>", "or", "0.5", "mg", "bumetanide/573", "mg", "potassium", "chloride"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [27, 28]}}
{"token": ["The", "interaction", "between", "almotriptan", ",", "a", "5-HT1B/1D", "C2987634#ent", "<e1>", ",", "and", "the", "potent", "CYP3A4", "inhibitor", "C0022625#ent", "<e2>", "was", "examined", "in", "16", "healthy", "volunteers"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [15, 16]}}
{"token": ["These", "results", "also", "suggest", "that", "human", "melanoma", "cells", "generate", "LTB4", "and", "LTC4", "from", "C3889163#ent", "<e1>", ",", "and", "that", "this", "process", "is", "catalyzed", "by", "two", "C3540790#ent", "<e2>", ":", "LTA4", "hydrolase", "LTC4", "synthase"], "h": {"id": "C3889163", "name": "C3889163#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [24, 25]}}
{"token": ["This", "report", "describes", "a", "patient", "who", "developed", "marked", "generalized", "adenopathy", "C0027726#ent", "<e1>", "receiving", "mephenytoin", "(", "mesantoin", ")", "for", "a", "C0014544#ent", "<e2>"], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [19, 20]}}
{"token": ["The", "actions", "of", "the", "two", "peptides", ",", "vasoactive", "intestinal", "peptide", "VIP", ")", "and", "peptide", "histidine", "isoleucine", "C1333690#ent", "<e1>", ")", "have", "been", "compared", "to", "that", "of", "C0282211#ent", "<e2>", "on", "the", "smooth", "muscle", "systems", "the", "isolated", "blood-perfused", "dog", "spleen", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [25, 26]}}
{"token": ["The", "current", "experiment", "compared", "the", "effects", "of", "raclopride", "(", "a", "selective", "D2", "receptor", "antagonist", "and", "C0074160#ent", "<e1>", "a", "selective", "C0019593#ent", "<e2>", "in", "the", "response-reinstating", "effects", "of", "food", "reinforcement"], "h": {"id": "C0074160", "name": "C0074160#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [19, 20]}}
{"token": ["Dying", "neurons", "in", "the", "pyramidal", "cell", "layer", "CA1", "and", "CA3", "areas", ",", "entorhinal", "and", "piriform", "cortices", "and", "C0002707#ent", "<e1>", "also", "expressed", "Bcl-2", ",", "Bax", "and", "C1332397#ent", "<e2>", "following", "excitotoxicity", ",", "although", "many", "dying", "cells", "not", "."], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [25, 26]}}
{"token": ["This", "effect", "was", ",", "however", ",", "limited", "to", "patients", "who", "were", "receiving", "C0010980#ent", "<e1>", "for", "reasons", "(", "mostly", "C0023530#ent", "<e2>", ")", "other", "than", "TMP-SMX", "allergy", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [18, 19]}}
{"token": ["Onset", "of", "synthesis", "of", "the", "C1417054#ent", "<e1>", "development", "was", "analogous", "to", "C1412578#ent", "<e2>", ",", "in", "contrast", ",", "did", "not", "reach", "adult", "synthesis", "rates", "immediately", "after", "birth", "."], "h": {"id": "C1417054", "name": "C1417054#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412578", "name": "C1412578#ent", "pos": [11, 12]}}
{"token": ["Ad-MMP-9", "infection", "stimulated", "C3849574#ent", "<e1>", ",", "and", "electrophoretic", "mobility", "shift", "assay", "an", "increase", "in", "C2986464#ent", "<e2>"], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "there", "was", "a", "lower", "expression", "of", "C1706383#ent", "<e1>", "and", "zif-268", "in", "the", "core", "of", "the", "C1725733#ent", "<e2>", "in", "the", "SHR", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1725733", "name": "C1725733#ent", "pos": [18, 19]}}
{"token": ["Promoter", "properties", "analyzed", "for", "the", "convergently-overlapped", "E.", "coli", "genes", "coding", "for", "the", "C3811771#ent", "<e1>", "dnaQ", ")", "and", "the", "C0085431#ent", "<e2>", "rnh", ")", "."], "h": {"id": "C3811771", "name": "C3811771#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085431", "name": "C0085431#ent", "pos": [18, 19]}}
{"token": ["Side", "effects", "C1414863#ent", "<e1>", ")", "of", "antipsychotics", "are", "considered", "a", "major", "source", "of", "C2364135#ent", "<e2>"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [13, 14]}}
{"token": ["Agarose", "cross-linked", "with", "divinyl", "sulphone", "C1864871#ent", "<e1>", ")", "is", "a", "new", "matrix", "for", "chromatography", "and", "immobilized", "C3541394#ent", "<e2>", "that", "has", "distinct", "advantages", "over", "common", "agarose", "gels"], "h": {"id": "C1864871", "name": "C1864871#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["Similar", "degrees", "of", "C0796254#ent", "<e1>", "occurred", "in", "IR4", "dogs", "experienced", "both", "irradiation", "and", "loss", "of", "C0722058#ent", "<e2>", "and", "UN4", "and", "HY4", "dogs", "which", "experienced", "only", "loss", "of", "C0722058#ent", "<e2>", "."], "h": {"id": "C0796254", "name": "C0796254#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0722058", "name": "C0722058#ent", "pos": [15, 16]}}
{"token": ["Since", "both", "C1332027#ent", "<e1>", "muscarinic", "receptors", "coupled", "to", "phosphatidylinositol", "hydrolysis", "we", "tested", "the", "hypothesis", "that", "C2936882#ent", "<e2>", "increases", "adrenergic-", "but", "not", "cholinergic-mediated", "inositol", "triphosphate", "production", "."], "h": {"id": "C1332027", "name": "C1332027#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "the", "C1332027#ent", "<e1>", "blocking", "action", "was", "not", "evident", "in", "the", "C2936882#ent", "<e2>", ",", "progesterone-primed", "ovariectomized", "rats", "similarly", "pretreated", "with", "LY", "78335", "."], "h": {"id": "C1332027", "name": "C1332027#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [13, 14]}}
{"token": ["Previous", "studies", "have", "demonstrated", "that", "C0071097#ent", "<e1>", ",", "a", "peroxisome", "proliferator-activated", "receptor", "gamma", "PPARgamma", ")", "C0243192#ent", "<e2>", ",", "inhibits", "ischemia-induced", "injury", "in", "various", "tissues", "including", "neural", "tissue"], "h": {"id": "C0071097", "name": "C0071097#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [15, 16]}}
{"token": ["The", "two", "available", "TZDs", ",", "C0071097#ent", "<e1>", "and", "rosiglitazone", ",", "are", "peroxisome", "proliferator-activated", "receptor-gamma", "PPAR-gamma", ")", "C0243192#ent", "<e2>", "that", "influence", "gene", "expression", "key", "proteins", "involved", "in", "regulating", "glucose", "lipid", "metabolism"], "h": {"id": "C0071097", "name": "C0071097#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [16, 17]}}
{"token": ["C1415009#ent", "<e1>", "also", "differentiated", "from", "other", "C0085744#ent", "<e2>", "that", "the", "catalytic", "base", "access", "both", "C-2", "and", "C-4", "in", "the", "normal", "catalytic", "pathway"], "h": {"id": "C1415009", "name": "C1415009#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085744", "name": "C0085744#ent", "pos": [6, 7]}}
{"token": ["C1415009#ent", "<e1>", "the", "only", "member", "of", "the", "C0085744#ent", "<e2>", "a", "cationic", "residue", "Arg-94", ",", "situated", "in", "the", "binding", "site", "the", "acyl", "moiety", "the", "substrate", "."], "h": {"id": "C1415009", "name": "C1415009#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085744", "name": "C0085744#ent", "pos": [7, 8]}}
{"token": ["A", "possible", "C0242911#ent", "<e1>", "property", "of", "the", "GABA-ergic", "anticonvulsant", "C0037567#ent", "<e2>", "was", "examined", "by", "use", "of", "a", "double-blind", "placebo-controlled", "ABA", "in", "5", "acutely", "ill", "manic", "patients", "."], "h": {"id": "C0242911", "name": "C0242911#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [9, 10]}}
{"token": ["The", "present", "studies", "were", "undertaken", "to", "determine", "whether", "two", "clinically", "effective", ",", "but", "structurally", "highly", "dissimilar", ",", "C0242911#ent", "<e1>", "lithium", "and", "C0037567#ent", "<e2>", "regulate", "synaptic", "expression", "AMPA", "receptor", "subunit", "glutamate", "receptor", "1", "GluR1", ")", "."], "h": {"id": "C0242911", "name": "C0242911#ent", "pos": [17, 18]}, "relation": "therapeutic_class_of", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [21, 22]}}
{"token": ["Two", "clinically", "effective", ",", "structurally", "dissimilar", ",", "C0242911#ent", "<e1>", "lithium", "and", "C0037567#ent", "<e2>", "(", "VPA", ")", ",", "down-regulate", "synaptic", "expression", "AMPA", "receptor", "subunit", "GluR1", "in", "hippocampus", "in", "chronically", "treated", "rats", "."], "h": {"id": "C0242911", "name": "C0242911#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [11, 12]}}
{"token": ["The", "handwriting", "of", "18", "schizophrenic", "patients", "before", "and", "during", "treatment", "with", "typical", "(", "haloperidol", ",", "C0062103#ent", "<e1>", "and", "atypical", "(", "clozapine", ",", "risperidone", ")", "C0040615#ent", "<e2>", "examined", "."], "h": {"id": "C0062103", "name": "C0062103#ent", "pos": [15, 16]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [24, 25]}}
{"token": ["These", "data", "show", "that", "C0244988#ent", "<e1>", "is", "activated", "by", "UV", "irradiation", "through", "the", "C1332120#ent", "<e2>", "signaling", "pathway", "phosphorylates", "p21", "at", "ser-114", "for", "its", "degradation", "by", "the", "proteasome", "."], "h": {"id": "C0244988", "name": "C0244988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332120", "name": "C1332120#ent", "pos": [13, 14]}}
{"token": ["To", "our", "knowledge", ",", "this", "is", "the", "first", "demonstration", "of", "C0244988#ent", "<e1>", "as", "the", "missing", "link", "between", "UV-induced", "C1332120#ent", "<e2>", "activation", "and", "p21", "degradation", "."], "h": {"id": "C0244988", "name": "C0244988#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332120", "name": "C1332120#ent", "pos": [18, 19]}}
{"token": ["These", "findings", ",", "with", "C0235222#ent", "<e1>", "in", "the", "absence", "of", "clinical", "features", "of", "C0010481#ent", "<e2>", "suggested", "an", "ectopic", "ACTH", "syndrome"], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [13, 14]}}
{"token": ["In", "a", "few", "patients", ",", "C1539521#ent", "<e1>", "was", "due", "to", "C0018203#ent", "<e2>", "the", "liver", ",", "such", "as", "tuberculosis", "and", "schistosomiasis", "."], "h": {"id": "C1539521", "name": "C1539521#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018203", "name": "C0018203#ent", "pos": [10, 11]}}
{"token": ["Atrial", "fibrillation", "AF", ")", "is", "common", "in", "pacemaker", "patients", "with", "sinus", "node", "dysfunction", "SND", ")", "and", "may", "result", "in", "rapid", "ventricular", "pacing", "C1706109#ent", "<e1>", ")", "in", "the", "C1704844#ent", "<e2>", "mode", "."], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1704844", "name": "C1704844#ent", "pos": [27, 28]}}
{"token": ["This", "work", "examines", "the", "C0017237#ent", "<e1>", "behavior", "of", "C0032253#ent", "<e2>", "the", "presence", "of", "a", "series", "of", "hydrophobic", "pharmaceuticals", "to", "determine", "whether", "there", "is", "any", "correlation", "between", "C0017237#ent", "<e1>", "and", "physicochemical", "parameters", "of", "drug", "solutes"], "h": {"id": "C0017237", "name": "C0017237#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032253", "name": "C0032253#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "epinephrine", ",", "C0021246#ent", "<e1>", ",", "acetylsalicylic", "acid", "dexamethasone", ",", "and", "cyclic", "AMP", "C1415826#ent", "<e2>", "activity", "in", "in", "the", "rabbit", "iris", "were", "studied", "in", "vitro"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415826", "name": "C1415826#ent", "pos": [15, 16]}}
{"token": ["C0021246#ent", "<e1>", "and", "acetylsalicylic", "acid", "inhibited", "the", "C1415826#ent", "<e2>", "activity", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415826", "name": "C1415826#ent", "pos": [7, 8]}}
{"token": ["In", "C57BL/6J", "compared", "with", "C57BL/6N", "mice", "K/M", "produced", "higher", "HR", ",", "and", "%", "FS", "and", "C1420610#ent", "<e1>", "produced", "smaller", "C3813715#ent", "<e2>", "."], "h": {"id": "C1420610", "name": "C1420610#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3813715", "name": "C3813715#ent", "pos": [19, 20]}}
{"token": ["Production", "of", "C2985149#ent", "<e1>", "was", "increased", "by", "oestradiol-17", "beta", "C0039286#ent", "<e2>", "and", "4-OH", "tamoxifen"], "h": {"id": "C2985149", "name": "C2985149#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [9, 10]}}
{"token": ["Production", "of", "C2985149#ent", "<e1>", "was", "increased", "by", "oestradiol-17", "beta", "tamoxifen", "and", "C0039286#ent", "<e2>"], "h": {"id": "C2985149", "name": "C2985149#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [11, 12]}}
{"token": ["This", "macromolecular", "assemblage", "the", "bifunctional", "glutamyl-prolyl-tRNA", "synthetase", "the", "seven", "monospecific", "isoleucyl", ",", "leucyl", ",", "methionyl", ",", "glutaminyl", ",", "C0024375#ent", "<e1>", ",", "arginyl", "and", "C0004022#ent", "<e2>", "and", "the", "three", "auxiliary", "p43", ",", "p38", "and", "p18", "proteins"], "h": {"id": "C0024375", "name": "C0024375#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0004022", "name": "C0004022#ent", "pos": [23, 24]}}
{"token": ["C0016860#ent", "<e1>", "has", "been", "reported", "to", "increase", "the", "activity", "of", "C0000359#ent", "<e2>", "in", "tissue", "extracts", "oestradiol-treated", "rat", "myometrium", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000359", "name": "C0000359#ent", "pos": [10, 11]}}
{"token": ["C0146337#ent", "<e1>", "(", "TL", ")", "oily", "gels", "of", "hydrogenated", "soybean", "phospholipid", "and", "C0015683#ent", "<e2>", "prepared", ",", "and", "the", "inhibitory", "effect", "the", "gels", "on", "the", "growth", "of", "granulation", "tissue", "evaluated", "in", "a", "carrageenin-induced", "rat", "granulation", "model", "."], "h": {"id": "C0146337", "name": "C0146337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015683", "name": "C0015683#ent", "pos": [12, 13]}}
{"token": ["Previous", "studies", "in", "our", "lab", "have", "shown", "that", "one", "C0017337#ent", "<e1>", "that", "may", "be", "regulated", "by", "C0037567#ent", "<e2>", "is", "the", "78-kilodalton", "glucose-regulated", "protein", "GRP78", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [16, 17]}}
{"token": ["This", "is", "the", "first", "demonstration", "of", "increased", "expression", "of", "C0017337#ent", "<e1>", "in", "the", "inositol", "biosynthetic", "pathway", "both", "lithium", "and", "C0037567#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "C0012582#ent", "<e1>", "on", "platelet", "aggregation", "ex", "vivo", "in", "vitro", "on", "platelet", "cyclic", "AMP", "phosphodiesterase", "C1849508#ent", "<e2>", ")", "were", "studied", ",", "and", "the", "mechanism", "of", "the", "ex", "vivo", "effects", "was", "assessed", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1849508", "name": "C1849508#ent", "pos": [17, 18]}}
{"token": ["C1333522#ent", "<e1>", ",", "vWF", ",", "tPA", "and", "C1705527#ent", "<e2>", "determined", "by", "ELISA", ",", "whereas", "tPA", "and", "PAI-1", "activities", "using", "chromogenic", "methods", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705527", "name": "C1705527#ent", "pos": [7, 8]}}
{"token": ["The", "levels", "of", "plasm", "prethrombotic", "state", "molecular", "markers", "C1333522#ent", "<e1>", ",", "TFPI", ",", "TpP", ",", "C1705527#ent", "<e2>", ",", "P-S", ",", "TAT", "and", "D-D", "were", "measured", "by", "using", "ELISA", "method", "transmission", "immunity", "nephelometry", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705527", "name": "C1705527#ent", "pos": [15, 16]}}
{"token": ["S-laminin", "is", "a", "C1334043#ent", "<e1>", "of", "laminin", "that", "is", "concentrated", "in", "the", "synaptic", "cleft", "the", "C0751950#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [15, 16]}}
{"token": ["Using", "immunohistochemistry", "and", "Western", "Blot", "analysis", "we", "found", "that", "the", "extended", "cellular", "life", "induced", "by", "C1166521#ent", "<e1>", "was", "paralleled", "by", "an", "increase", "of", "C0376515#ent", "<e2>", "expression", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [23, 24]}}
{"token": ["Recently", "pharmacoepigenomic", "modulators", "of", "key", "C1417679#ent", "<e1>", "and", "pathways", ",", "such", "as", "promoter", "methylation", "MLH1", "and", "C0376571#ent", "<e2>", "C1417679#ent", "<e1>", ")", "and", "microRNA", "regulation", "PTEN/AKT", "and", "NF-kappaB", "pathways", "have", "been", "implicated", "in", "ovarian", "cancer", "chemoresponse", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0376571", "name": "C0376571#ent", "pos": [16, 17]}}
{"token": ["These", "CGFs", "define", "a", "minimum", "of", "15", "C1417679#ent", "<e1>", ",", "six", "of", "which", "are", "newly", "localized", "to", "the", "C0376571#ent", "<e2>", "region", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376571", "name": "C0376571#ent", "pos": [18, 19]}}
{"token": ["To", "investigate", "whether", "cells", "from", "hereditary", "nonpolyposis", "colorectal", "cancer", "C0879290#ent", "<e1>", ")", "patients", ",", "a", "genetic", "condition", "by", "constitutional", "mutations", "C1709414#ent", "<e2>", "associated", "with", "predisposition", "to", "colorectal", "carcinoma", "CRC", ")", ",", "could", "present", "a", "higher", "G2", "chromosomal", "radiosensitivity", "."], "h": {"id": "C0879290", "name": "C0879290#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1709414", "name": "C1709414#ent", "pos": [20, 21]}}
{"token": ["Hereditary", "nonpolyposis", "colorectal", "cancer", "C0879290#ent", "<e1>", ")", "is", "commonly", "associated", "with", "least", "three", "currently", "known", "C1709414#ent", "<e2>", "(", "a", ")", "hMSH2", ";", "(", "b", ")", "hMLH1", ";", "and", "(", "c", ")", "hMSH6", "."], "h": {"id": "C0879290", "name": "C0879290#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709414", "name": "C1709414#ent", "pos": [15, 16]}}
{"token": ["Electron", "microscopy", "FITC-labeled", "phalloidin", "staining", "revealed", "thick", "submembranous", "C1334752#ent", "<e1>", "the", "pseudopods", "of", "the", "shape-changed", "cells", "by", "C1414504#ent", "<e2>", "."], "h": {"id": "C1334752", "name": "C1334752#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [17, 18]}}
{"token": ["These", "currents", "were", "carried", "by", "Na(+", ")", "ions", ",", "were", "inhibited", "by", "C0002502#ent", "<e1>", "and", "by", "cells", "exposure", "to", "C0815040#ent", "<e2>", "(", "pH", "6.3", ")", "extracellular", "solutions"], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [19, 20]}}
{"token": ["Finding", "C1259497#ent", "<e1>", "(", "UGT", ")", "require", "C0010536#ent", "<e2>", "C-mediated", "phosphorylation", "important", "information", "that", "allows", "manipulation", "of", "this", "critical", "system"], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [7, 8]}}
{"token": ["Incubation", "of", "cells", "with", "phosphodiesterase", "inhibitors", "aminophylline", ",", "theophylline", "or", "C0030899#ent", "<e1>", "all", "resulted", "in", "an", "increase", "in", "C0087140#ent", "<e2>", "mRNA", "."], "h": {"id": "C0030899", "name": "C0030899#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [18, 19]}}
{"token": ["Finally", ",", "in", "vitro", "incubation", "with", "purified", "C1826724#ent", "<e1>", "indicated", "that", "C0770893#ent", "<e2>", "had", "no", "direct", "effect", "on", "C1826724#ent", "<e1>", "activity", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [7, 8]}}
{"token": ["On", "the", "other", "hand", ",", "C0770893#ent", "<e1>", "reduced", "both", "C1826724#ent", "<e2>", "membrane", "translocation", "and", "kinase", "activity", "ANG-stimulated", "cells", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [9, 10]}}
{"token": ["In", "PMA-activated", "cells", ",", "C0770893#ent", "<e1>", "reduced", "membrane", "C1826724#ent", "<e2>", "activity", "but", "we", "did", "not", "observe", "any", "alteration", "of", "C1826724#ent", "<e2>", "membrane", "translocation", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [8, 9]}}
{"token": ["The", "levels", "of", "plasma", "membrane", "GP", "IV", "platelet", "surface-associated", "C1336626#ent", "<e1>", "tended", "to", "be", "normalized", "during", "C0751598#ent", "<e2>", "treatment", ",", "whereas", "the", "presence", "of", "an", "altered", "form", "of", "C1336626#ent", "<e1>", "persisted", "."], "h": {"id": "C1336626", "name": "C1336626#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0751598", "name": "C0751598#ent", "pos": [16, 17]}}
{"token": ["Stress-induced", "expression", "MSN2", ",", "MOT3", ",", "and", "C0342727#ent", "<e1>", "is", "diminished", "in", "sko1", "mutant", "cells", "while", "transcriptional", "regulation", "C2697613#ent", "<e2>", "seems", "to", "be", "unaffected", "."], "h": {"id": "C0342727", "name": "C0342727#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2697613", "name": "C2697613#ent", "pos": [18, 19]}}
{"token": ["Including", "C1415014#ent", "<e1>", ",", "these", "three", "C1447694#ent", "<e2>", "almost", "exclusively", "produced", "by", "the", "prostate", "."], "h": {"id": "C1415014", "name": "C1415014#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [6, 7]}}
{"token": ["In", "the", "animals", "treated", "with", "highest", "doses", "of", "C3812677#ent", "<e1>", "(", "4.0", "mg/kg/day", "per", "os", ")", "and", "C2757070#ent", "<e2>", "(", "42.5", "mg/kg/day", "s.c", ".", ")"], "h": {"id": "C3812677", "name": "C3812677#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [17, 18]}}
{"token": ["These", "include", "C0010762#ent", "<e1>", "hydroxylates", "LCA", "to", "more", "soluble", "forms", "and", "sulfotransferase", "(", "C1420519#ent", "<e2>", ")", "which", "by", "sulphation", "of", "LCA", "makes", "it", "more", "readily", "solublein", "bile", "enhances", "its", "faecal", "excretion"], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420519", "name": "C1420519#ent", "pos": [13, 14]}}
{"token": ["We", "report", "three", "cardiac", "transplant", "recipients", ",", "treated", "with", "C0009262#ent", "<e1>", "for", "cyclosporin", "A", "gout", ",", "who", "developed", "C3714552#ent", "<e2>", "to", "colchicine", "myoneuropathy", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [18, 19]}}
{"token": ["The", "influence", "of", "C1417500#ent", "<e1>", "+", "on", "the", "kinetic", "behaviour", "C2827577#ent", "<e2>", "rat", "testis", "has", "been", "investigated", "using", "capronaldehyde", "as", "substrate", "."], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2827577", "name": "C2827577#ent", "pos": [10, 11]}}
{"token": ["The", "Y1", "receptor", "antagonist", "BIBP", "3226", "did", "not", "inhibit", "the", "effects", "of", "C1417815#ent", "<e1>", "on", "SS", ",", "C1333674#ent", "<e2>", "or", "AVP", "release", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333674", "name": "C1333674#ent", "pos": [17, 18]}}
{"token": ["Mn2", "+", "transforms", "C1707154#ent", "<e1>", "into", "a", "protein", "kinase", "dual", "specificity", "shifting", "its", "specificity", "from", "C1420479#ent", "<e2>", "a", "serine/threonine", "and", "tyrosine", "kinase"], "h": {"id": "C1707154", "name": "C1707154#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420479", "name": "C1420479#ent", "pos": [15, 16]}}
{"token": ["The", "self-complementary", "dinucleoside", "monophosphates", "CpG", "and", "C1415375#ent", "<e1>", "and", "the", "complementary", "mixture", "GpU", "+", "C3540812#ent", "<e2>", "form", "intermolecular", "hydrogen-bonded", "complexes", "at", "low", "temperatures"], "h": {"id": "C1415375", "name": "C1415375#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540812", "name": "C3540812#ent", "pos": [14, 15]}}
{"token": ["The", "late", "action", "potentials", "the", "C4283742#ent", "<e1>", "were", "also", "suppressed", "by", "local", "application", "C0026818#ent", "<e2>", "around", "the", "cell", "body"], "h": {"id": "C4283742", "name": "C4283742#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "C1537647#ent", "<e1>", "specifically", "reacts", "with", "C0041484#ent", "<e2>"], "h": {"id": "C1537647", "name": "C1537647#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041484", "name": "C0041484#ent", "pos": [9, 10]}}
{"token": ["Angiotensin", "(", "C1367482#ent", "<e1>", ")", "converting", "enzyme", "inhibitors", "Ang", "II", "type", "1", "receptor", "antagonists", "improve", "insulin", "resistance", "patients", "with", "C0085580#ent", "<e2>", "which", "suggest", "that", "tissue", "Ang", "II", "involved", "in", "insulin", "resistance", "patients", "with", "hypertension", "."], "h": {"id": "C1367482", "name": "C1367482#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [19, 20]}}
{"token": ["Western", "immunoblot", "analysis", "bands", "at", "43", "-", "46", "C1839259#ent", "<e1>", "that", "were", "similar", "in", "volume", "for", "diabetic", "and", "C0362046#ent", "<e2>", "fibroblasts", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [18, 19]}}
{"token": ["The", "patients", "administered", "0.5", "mg", "C0058031#ent", "<e1>", "and", "100", "mg", "C0077163#ent", "<e2>", "at", "the", "onset", "of", "their", "headache", "and", "an", "additional", "0.5", "mg", "C0058031#ent", "<e1>", "if", "satisfactory", "headache", "relief", "was", "not", "obtained", "."], "h": {"id": "C0058031", "name": "C0058031#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0077163", "name": "C0077163#ent", "pos": [10, 11]}}
{"token": ["Coxiella", "burnetii", "the", "causative", "agent", "C0034362#ent", "<e1>", ",", "a", "widespread", "C0043528#ent", "<e2>", "."], "h": {"id": "C0034362", "name": "C0034362#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "if", "the", "abdominal", "leak", "point", "pressure", "(", "C0740201#ent", "<e1>", ")", "correlates", "with", "objective", "C0021167#ent", "<e2>", "severity", "in", "patients", "suffering", "from", "post-prostatectomy", "stress", "incontinence", "."], "h": {"id": "C0740201", "name": "C0740201#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021167", "name": "C0021167#ent", "pos": [15, 16]}}
{"token": ["C0387337#ent", "<e1>", "found", "to", "moderately", "inhibit", "C0008145#ent", "<e2>", "Serratia", "marcescens", "the", "mode", "of", "inhibition", "being", "non-competitive", "."], "h": {"id": "C0387337", "name": "C0387337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008145", "name": "C0008145#ent", "pos": [6, 7]}}
{"token": ["C0035334#ent", "<e1>", "a", "feature", "of", "C0271097#ent", "<e2>", "usually", "develops", "as", "a", "slowly", "progressive", "process", "."], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271097", "name": "C0271097#ent", "pos": [5, 6]}}
{"token": ["C0062505#ent", "<e1>", "begins", "as", "a", "febrile", "C3494358#ent", "<e2>", "and", "quickly", "progresses", "to", "a", "life-threatening", "cardiorespiratory", "failure"], "h": {"id": "C0062505", "name": "C0062505#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3494358", "name": "C3494358#ent", "pos": [6, 7]}}
{"token": ["Benign", "C0522253#ent", "<e1>", "also", "be", "considered", "in", "the", "differential", "diagnosis", "this", "type", "of", "C0018681#ent", "<e2>", "in", "the", "elderly", "."], "h": {"id": "C0522253", "name": "C0522253#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [13, 14]}}
{"token": ["Diagnostic", "distribution", "as", "follows", ":", "68", "patients", "(", "70.1", "%", ")", "consulted", "due", "to", "cough", "headache", "11", "(", "11.3", "%", ")", "due", "to", "C0522253#ent", "<e1>", "18", "(", "18.6", "%", ")", "due", "to", "C0018681#ent", "<e2>"], "h": {"id": "C0522253", "name": "C0522253#ent", "pos": [23, 24]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [32, 33]}}
{"token": ["Only", "eight", "C1415793#ent", "<e1>", "mutations", "have", "been", "reported", "in", "six", "C0036391#ent", "<e2>", "families", "."], "h": {"id": "C1415793", "name": "C1415793#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0036391", "name": "C0036391#ent", "pos": [10, 11]}}
{"token": ["C0277554#ent", "<e1>", "mitochondrial", "ATP", "synthase", "to", "the", "most", "severe", "C0751651#ent", "<e2>"], "h": {"id": "C0277554", "name": "C0277554#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751651", "name": "C0751651#ent", "pos": [9, 10]}}
{"token": ["Five", "cases", "of", "accelerated", "or", "C0020540#ent", "<e1>", "occurred", "in", "young", "adults", "a", "few", "weeks", "of", "C0035085#ent", "<e2>", "reported", "here", "."], "h": {"id": "C0020540", "name": "C0020540#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035085", "name": "C0035085#ent", "pos": [15, 16]}}
{"token": ["This", "case", "report", "a", "patient", "who", "presented", "with", "severe", "C0011168#ent", "<e1>", ",", "found", "to", "be", "due", "to", "a", "large", "C0030299#ent", "<e2>", "into", "the", "mediastinum", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030299", "name": "C0030299#ent", "pos": [19, 20]}}
{"token": ["Despite", "the", "incorporation", "of", "up", "to", "2", "mol", "32P/mol", "carboxylase", "subunit", "(", "C0003766#ent", "<e1>", "and", "0.6", "mol/subunit", "(", "kinase", "II", ",", "phosphorylation", "by", "either", "C0031727#ent", "<e2>", "causes", "no", "change", "in", "carboxylase", "activity"], "h": {"id": "C0003766", "name": "C0003766#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [24, 25]}}
{"token": ["20a", "exhibits", "higher", "affinity", "for", "the", "C1417683#ent", "<e1>", "containing", "subtype", "than", "for", "the", "C1423974#ent", "<e2>", "containing", "counterpart", ",", "while", "20b", "possesses", "reversed", "selectivity", "."], "h": {"id": "C1417683", "name": "C1417683#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423974", "name": "C1423974#ent", "pos": [13, 14]}}
{"token": ["The", "beta", "subunit-specific", "antibodies", "identified", "the", "presence", "of", "beta1a", "in", "skeletal", "muscle", "C1417683#ent", "<e1>", "in", "heart", ";", "and", "C1417683#ent", "<e1>", ",", "beta3", ",", "and", "C1423974#ent", "<e1>", "in", "brain", "."], "h": {"id": "C1417683", "name": "C1417683#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423974", "name": "C1423974#ent", "pos": [24, 25]}}
{"token": ["C1517662#ent", "<e1>", "partially", "blocked", "the", "inhibitory", "effect", "of", "C0051424#ent", "<e2>", "and", "ACh-induced", "contractions", "while", "the", "5-HT", "uptake", "blocker", ",", "fluoxetine", ",", "potentiated", "the", "effect", "of", "5-HT", "on", "ACh-induced", "contractions", "."], "h": {"id": "C1517662", "name": "C1517662#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0051424", "name": "C0051424#ent", "pos": [8, 9]}}
{"token": ["The", "clinical", "syndrome", "by", "C0030528#ent", "<e1>", "overlaps", "with", "other", "C0015967#ent", "<e2>", "illnesses", "and", "can", "not", "be", "distinguished", "from", "typhoid", "fever"], "h": {"id": "C0030528", "name": "C0030528#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [9, 10]}}
{"token": ["As", "molecular", "oxygen", "to", "nitrite", "formed", "was", "consumed", "in", "the", "enzymatic", "oxidation", "of", "pyruvic", "oxime", "nitrite", ",", "the", "C0014442#ent", "<e1>", "was", "thought", "to", "be", "a", "C1564138#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1564138", "name": "C1564138#ent", "pos": [25, 26]}}
{"token": ["Higher", "C0014442#ent", "<e1>", "expression", "of", "catechol", "2", "3", ",", "C1564138#ent", "<e2>", "was", "also", "obtained", "in", "leaked", "cells", "due", "to", "better", "maintenance", "of", "plasmid", "stability", "and", "higher", "plasmid", "copy", "number", "with", "regard", "to", "free", "cells"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1564138", "name": "C1564138#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "physician", "diagnosed", "C0149514#ent", "<e1>", ",", "pneumonia", "and", "frequent", "C0009443#ent", "<e2>", "decreased", "significantly", "."], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [11, 12]}}
{"token": ["In", "L.", "minor", "grown", "in", "sterile", "culture", "the", "primary", "enzymes", "of", "nitrate", "assimilation", "C0028123#ent", "<e1>", "NR", ")", ",", "nitrite", "reductase", "NiR", ")", "and", "glutamate", "dehydrogenase", "C1425393#ent", "<e2>", ")", "change", "in", "response", "to", "nitrogen", "source"], "h": {"id": "C0028123", "name": "C0028123#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1425393", "name": "C1425393#ent", "pos": [25, 26]}}
{"token": ["Constitutively", "active", "PI3-K", "also", "enhanced", "ENaC", "activity", "but", "in", "a", "wortmannin", "and", "C0251991#ent", "<e1>", "sensitive", "manner", "with", "the", "effects", "of", "PI3-K", "and", "C0079973#ent", "<e2>", "not", "being", "additive", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079973", "name": "C0079973#ent", "pos": [22, 23]}}
{"token": ["Surprisingly", ",", "C1838100#ent", "<e1>", "patients", "exhibit", "hypersensitivity", "to", "the", "C0020615#ent", "<e2>", "actions", "of", "sulfonylurea", "therapy", "."], "h": {"id": "C1838100", "name": "C1838100#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [9, 10]}}
{"token": ["Myt1", "or", "C1417585#ent", "<e1>", "interactions", "with", "the", "HDAC-binding", "form", "of", "C1426186#ent", "<e2>", "conferred", "repression", "on", "a", "heterologous", "promoter", "."], "h": {"id": "C1417585", "name": "C1417585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426186", "name": "C1426186#ent", "pos": [10, 11]}}
{"token": ["Oxygen", "toxicity", "Saccharomyces", "cerevisiae", "the", "copper/zinc", "superoxide", "dismutase", "(", "C0669516#ent", "<e1>", ")", "can", "be", "suppressed", "by", "overexpression", "of", "the", "S.", "cerevisiae", "C1538299#ent", "<e2>"], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1538299", "name": "C1538299#ent", "pos": [21, 22]}}
{"token": ["C0041345#ent", "<e1>", ",", "which", "has", "a", "structure", "similar", "to", "that", "of", "C0042435#ent", "<e2>", ",", "was", "used", "as", "the", "internal", "standard"], "h": {"id": "C0041345", "name": "C0041345#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [11, 12]}}
{"token": ["Ablation", "of", "capsaicin-sensitive", "sensory", "nerves", "as", "well", "as", "application", "of", "C0360097#ent", "<e1>", "to", "the", "gastric", "mucosa", "to", "modify", "the", "excitatory", "effects", "of", "C0289932#ent", "<e2>", "or", "gastrin-I", "on", "pepsinogen", "and", "acid", "secretion"], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0289932", "name": "C0289932#ent", "pos": [22, 23]}}
{"token": ["In", "eNOS-transfected", "COS-7", "cells", "staurosporine-induced", "activation", "of", "caspase-3", "and", "C0032405#ent", "<e1>", "PARP", ")", "cleavage", "coincided", "with", "increased", "C1328053#ent", "<e2>", "degradation", "and", "decreased", "activity", "."], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [17, 18]}}
{"token": ["The", "method", "was", "applicable", "to", "the", "screening", "and/or", "chemical", "diagnosis", "inherited", "C0025517#ent", "<e1>", "as", "phenylketonuria", "(", "C0031485#ent", "<e2>", ")", ",", "tyrosinemia", ",", "and", "Lowe", "syndrome"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [16, 17]}}
{"token": ["In", "order", "to", "demonstrate", "the", "C0025517#ent", "<e1>", "of", "myelinization", "in", "C0031485#ent", "<e2>", "we", "studied", "the", "visual", "evoked", "potentials", "VEP", ")", "in", "14", "C0031485#ent", "<e2>", "patients", "and", "in", "20", "normal", "subjects"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [10, 11]}}
{"token": ["Suppression", "of", "an", "C1419697#ent", "<e1>", "mutation", "by", "overexpression", "of", "C0812376#ent", "<e2>", "indicates", "that", "this", "small", "membrane", "protein", "interacts", "with", "other", "OTase", "components", ",", "most", "likely", "with", "Ost1p", "."], "h": {"id": "C1419697", "name": "C1419697#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812376", "name": "C0812376#ent", "pos": [9, 10]}}
{"token": ["Myoblasts", "lacking", "RhoE", "present", "with", "defective", "C3273319#ent", "<e1>", "activation", "and", "C0084340#ent", "<e2>", "inhibition", "at", "the", "onset", "of", "myoblast", "fusion"], "h": {"id": "C3273319", "name": "C3273319#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [10, 11]}}
{"token": ["Release", "of", "enzymes", "--", "especially", "C0030940#ent", "<e1>", "--", "causes", "irreversibility", "of", "initial", "C0271051#ent", "<e2>", "autolysis", "of", "cellular", "structures"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0271051", "name": "C0271051#ent", "pos": [12, 13]}}
{"token": ["The", "FixL", "heme-based", "sensor", ",", "despite", "its", "low", "affinity", "for", "oxygen", ",", "is", "much", "more", "reactive", "than", "C1417048#ent", "<e1>", "toward", "the", "large", "C0020924#ent", "<e2>"], "h": {"id": "C1417048", "name": "C1417048#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020924", "name": "C0020924#ent", "pos": [22, 23]}}
{"token": ["Freeze-thaw", "and", "cell", "lysis", "experiments", ",", "along", "with", "actinomycin", "D", "studies", ",", "suggested", "that", "CCL20", "and", "C0812246#ent", "<e1>", "are", "synthesized", "in", "response", "to", "C1421554#ent", "<e2>", "stimulation", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1421554", "name": "C1421554#ent", "pos": [23, 24]}}
{"token": ["This", "C1254351#ent", "<e1>", "has", "been", "suggested", "in", "combination", "with", "selective", "C2911696#ent", "<e2>", "the", "treatment", "of", "depression", "and", "was", "given", "to", "healthy", "males", "in", "the", "second", "study", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2911696", "name": "C2911696#ent", "pos": [10, 11]}}
{"token": ["As", "a", "tool", "for", "selecting", "the", "optimal", "perforators", "which", "will", "ultimately", "supply", "the", "C1412362#ent", "<e1>", ",", "preoperative", "imaging", "with", "computed", "tomography", "angiography", "C3813556#ent", "<e2>", ")", "has", "become", "increasingly", "popular", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [22, 23]}}
{"token": ["Their", "effectiveness", "against", "C0036572#ent", "<e1>", "produced", "by", "pentetrazole", "is", "less", "than", "that", "of", "C0070592#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0070592", "name": "C0070592#ent", "pos": [13, 14]}}
{"token": ["The", "authors", "have", "previously", "described", "the", "successful", "use", "of", "a", "five-day", "peri-operative", "prophylaxis", "regimen", "using", "nasal", "mupirocin", "C0040958#ent", "<e1>", "PPNMTT", ")", "to", "prevent", "C0343401#ent", "<e2>", "MRSA", ")", "infection", "."], "h": {"id": "C0040958", "name": "C0040958#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0343401", "name": "C0343401#ent", "pos": [23, 24]}}
{"token": ["We", "identified", "C1416881#ent", "<e1>", "protein", "2", "a", "FoxO3a", "target", "C0017337#ent", "<e2>", "in", "erythroid", "progenitors", "."], "h": {"id": "C1416881", "name": "C1416881#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["The", "C0017361#ent", "<e1>", "associated", "in", "one", "third", "of", "cases", "with", "progressive", "C0018784#ent", "<e2>", "SNHL", ")", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [11, 12]}}
{"token": ["This", "article", "addresses", "the", "growing", "challenge", "of", "the", "C0022661#ent", "<e1>", "uninsured", "in", "the", "United", "States", "describes", "how", "the", "current", "system", "C0740229#ent", "<e2>", "with", "the", "C0022661#ent", "<e1>", "uninsured", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0740229", "name": "C0740229#ent", "pos": [20, 21]}}
{"token": ["We", "identified", "recurrent", "gene", "fusions", "the", "5", "'", "untranslated", "region", "C1336641#ent", "<e1>", "to", "ERG", "or", "C1333361#ent", "<e2>", "in", "prostate", "cancer", "tissues", "with", "outlier", "expression", "."], "h": {"id": "C1336641", "name": "C1336641#ent", "pos": [10, 11]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333361", "name": "C1333361#ent", "pos": [15, 16]}}
{"token": ["We", "recently", "reported", "the", "identification", "of", "recurrent", "gene", "fusions", "the", "majority", "of", "prostate", "cancers", "the", "5", "'", "untranslated", "region", "the", "androgen-regulated", "gene", "C1336641#ent", "<e1>", "and", "the", "ETS", "family", "members", "ERG", ",", "C1333361#ent", "<e2>", ",", "and", "ETV4", "."], "h": {"id": "C1336641", "name": "C1336641#ent", "pos": [22, 23]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333361", "name": "C1333361#ent", "pos": [31, 32]}}
{"token": ["The", "resultant", "chimeric", "protein", "the", "C1335192#ent", "<e1>", "DNA-binding", "domains", "the", "transactivation", "domain", "FKHR", ",", "suggesting", "that", "C1847791#ent", "<e2>", "exerts", "its", "role", "in", "alveolar", "rhabdomyosarcomas", "dysregulation", "of", "PAX3-specific", "target", "genes", "."], "h": {"id": "C1335192", "name": "C1335192#ent", "pos": [5, 6]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1847791", "name": "C1847791#ent", "pos": [16, 17]}}
{"token": ["CASTing", "libraries", "constructed", "with", "mouse", "DNA", "fragments", "bound", "by", "mouse", "C1335192#ent", "<e1>", ",", "and", "human", "genomic", "DNA", "fragments", "bound", "by", "human", "C1335192#ent", "<e1>", "and", "the", "fusion", "protein", "C1847791#ent", "<e1>", "."], "h": {"id": "C1335192", "name": "C1335192#ent", "pos": [10, 11]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1847791", "name": "C1847791#ent", "pos": [27, 28]}}
{"token": ["The", "human", "kallikrein-related", "peptidase", "KLK", ")", "family", "consists", "of", "15", "highly", "conserved", "C2717971#ent", "<e1>", "which", "are", "encoded", "by", "the", "largest", "uninterrupted", "cluster", "of", "C1335528#ent", "<e2>", "the", "human", "genome", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335528", "name": "C1335528#ent", "pos": [23, 24]}}
{"token": ["The", "values", "of", "pIC(50", ")", "for", "the", "selective", "A(2A)-adenosine", "receptor", "antagonist", "C0387956#ent", "<e1>", "to", "antagonize", "equivalent", "responses", "to", "C1705556#ent", "<e2>", "and", "adenosine", "were", "8.28+/-0.08", "and", "8.28+/-0.06", "(", "P=0.99", ",", "n=6", ")", ",", "respectively", "."], "h": {"id": "C0387956", "name": "C0387956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [18, 19]}}
{"token": ["Therefore", ",", "some", "function", "of", "C1417020#ent", "<e1>", "may", "be", "regulated", "by", "a", "gene(s", ")", "near", "the", "C2742126#ent", "<e2>"], "h": {"id": "C1417020", "name": "C1417020#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2742126", "name": "C2742126#ent", "pos": [16, 17]}}
{"token": ["Sialidosis", "is", "a", "C0085078#ent", "<e1>", "by", "the", "deficiency", "of", "alpha-N-acetylneuraminidase", "(", "C1417680#ent", "<e2>", ";", "sialidase", ")", ",", "the", "key", "enzyme", "for", "the", "intralysosomal", "catabolism", "of", "sialylated", "glycoconjugates", "."], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417680", "name": "C1417680#ent", "pos": [11, 12]}}
{"token": ["Galactosialidosis", "is", "a", "C0085078#ent", "<e1>", "associated", "with", "combined", "deficiency", "of", "beta-galactosidase", "and", "C1417680#ent", "<e2>", ",", "caused", "by", "a", "defect", "of", "another", "lysosomal", "protein", "the", "protective", "protein"], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417680", "name": "C1417680#ent", "pos": [12, 13]}}
{"token": ["The", "PCR", "assay", "then", "used", "to", "attempt", "detection", "of", "Peptostreptococcus", "magnus", "DNA", "subgingival", "plaque", "samples", "from", "adult", "C0001342#ent", "<e1>", "patients", "and", "pus", "aspirates", "subjects", "with", "C0031024#ent", "<e2>"], "h": {"id": "C0001342", "name": "C0001342#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031024", "name": "C0031024#ent", "pos": [25, 26]}}
{"token": ["The", "PCR", "assay", "then", "applied", "to", "the", "detection", "of", "P.", "anaerobius", "DNA", "in", "subgingival", "plaque", "samples", "from", "adult", "C0001342#ent", "<e1>", "patients", "and", "pus", "aspirates", "subjects", "with", "C0031024#ent", "<e2>"], "h": {"id": "C0001342", "name": "C0001342#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031024", "name": "C0031024#ent", "pos": [26, 27]}}
{"token": ["Subsequently", ",", "she", "developed", "a", "C0022568#ent", "<e1>", ",", "on", "a", "separate", "occasion", ",", "an", "C0014583#ent", "<e2>", "that", "was", "associated", "with", "recrudescence", "of", "Lyme", "disease", "poor", "compliance", "the", "antibiotic", "regimen"], "h": {"id": "C0022568", "name": "C0022568#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014583", "name": "C0014583#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "the", "DNA", "polymerase", "in", "an", "oncogenic", "RNA", "virus", "like", "animal", "C0012892#ent", "<e1>", "can", "be", "rigorously", "classified", "as", "a", "C0596918#ent", "<e2>"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0596918", "name": "C0596918#ent", "pos": [20, 21]}}
{"token": ["C0008806#ent", "<e1>", "was", "as", "effective", "as", "tobramycin", "against", "P.", "cepacia", "and", "C0014836#ent", "<e2>"], "h": {"id": "C0008806", "name": "C0008806#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014836", "name": "C0014836#ent", "pos": [11, 12]}}
{"token": ["This", "indicator", "is", "an", "important", "predictor", "of", "the", "onset", "of", "C0035078#ent", "<e1>", "the", "risk", "of", "complications", "due", "to", "C1561643#ent", "<e2>"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [18, 19]}}
{"token": ["Finally", ",", "H2O2", "enhanced", "the", "expression", "of", "both", "C1366562#ent", "<e1>", "and", "CD18", "on", "C0272192#ent", "<e2>", "."], "h": {"id": "C1366562", "name": "C1366562#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0272192", "name": "C0272192#ent", "pos": [13, 14]}}
{"token": ["Recent", "studies", "have", "shown", "that", "lesions", "of", "the", "C0002707#ent", "<e1>", ",", "as", "well", "as", "systemic", "administration", "benzodiazepine", "receptor", "agonists", "block", "the", "C0085625#ent", "<e2>", "and", "defensive", "behavior", "observed", "when", "rats", "are", "exposed", "to", "stimuli", "associated", "with", "shock", "."], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085625", "name": "C0085625#ent", "pos": [21, 22]}}
{"token": ["MCPG", "treatment", "was", "also", "potent", "at", "inhibiting", "the", "augmentation", "of", "plasma", "C1334081#ent", "<e1>", "elicited", "by", "AV3V", "infusion", "of", "PGE2", ",", "although", "its", "C0237795#ent", "<e2>", "and", "tachycardiac", "actions", "were", "not", "influenced", "."], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [22, 23]}}
{"token": ["All", "non-tube-fed", "partners", "had", "normal", "food", "intakes", "body", "protein", "hepatic", "fatty", "acid", "synthesis", "C1704658#ent", "<e1>", ")", "and", "esterification", "(", "C2828055#ent", "<e2>", ")", ",", "palmitate", ",", "glucose", "and", "beta-hydroxybutyrate", "oxidation"], "h": {"id": "C1704658", "name": "C1704658#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2828055", "name": "C2828055#ent", "pos": [19, 20]}}
{"token": ["Whereas", "the", "symptomology", "for", "C1704658#ent", "<e1>", "has", "been", "established", ",", "that", "of", "C2828055#ent", "<e2>", "remains", "to", "be", "fully", "characterized", "."], "h": {"id": "C1704658", "name": "C1704658#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2828055", "name": "C2828055#ent", "pos": [12, 13]}}
{"token": ["Elevated", "ERK", "activity", "that", "contributed", "to", "apoptosis", "by", "C0059438#ent", "<e1>", "plus", "vanadate", "was", "supported", "by", "C0298346#ent", "<e2>", "and", "U0126", ",", "chemical", "inhibitor", "MEK/ERK", "signaling", "pathway", ",", "prevented", "apoptosis", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0298346", "name": "C0298346#ent", "pos": [15, 16]}}
{"token": ["Cyclic", "C1514550#ent", "<e1>", "phosphorylation", "of", "the", "enzyme", "by", "protein", "kinase", "ATP", ":", "C0031727#ent", "<e2>", "EC", "2.7.1.70", ")", "had", "no", "effect", "(", "Na+", "+", "K+)-ATPase", "activity"], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}}
{"token": ["C0031099#ent", "<e1>", "is", "a", "C0596823#ent", "<e2>", "modified", "by", "multiple", "risk", "factors"], "h": {"id": "C0031099", "name": "C0031099#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0596823", "name": "C0596823#ent", "pos": [4, 5]}}
{"token": ["The", "results", "show", "an", "increase", "in", "deaths", "due", "to", "both", "C2347435#ent", "<e1>", "and", "other", "C0221423#ent", "<e2>", "but", "a", "slight", "decrease", "in", "the", "proportion", "of", "post-mortems", "."], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [14, 15]}}
{"token": ["Correlation", "of", "results", "with", "gas", "chromatography", "0.912", "for", "phenobarbital", ",", "0.982", "for", "C0237417#ent", "<e1>", ",", "0.886", "for", "primidone", ",", "and", "0.966", "for", "C0015043#ent", "<e2>", "."], "h": {"id": "C0237417", "name": "C0237417#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [22, 23]}}
{"token": ["C0237417#ent", "<e1>", ",", "trimethadione", ",", "phenobarbitone", "and", "C0015043#ent", "<e2>", ",", "were", "studied", "on", "different", "in", "vitro", "in", "vivo", "skeletal", "muscle", "preparations", "which", "consisted", "of", "frog", "rectus", "rat", "phrenic", "nerve", "diaphragm", "cat", "gastrocnemius", "sciatic", "nerve", "preparations", "."], "h": {"id": "C0237417", "name": "C0237417#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [7, 8]}}
{"token": ["HA1077", "had", "little", "effect", "on", "C0056696#ent", "<e1>", "yet", "it", "potently", "inhibited", "protein", "kinases", "as", "cyclic", "nucleotide", "dependent", "protein", "kinases", "Ca2+/calmodulin", "dependent", "C1334539#ent", "<e2>"], "h": {"id": "C0056696", "name": "C0056696#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [21, 22]}}
{"token": ["Screening", "for", "Congenital", "Disorders", "Glycosylation", "(", "C2930997#ent", "<e1>", ")", "in", "144", "patients", "and", "for", "Smith-Lemli-Opitz", "syndrome", "C1416602#ent", "<e2>", ")", "in", "a", "selected", "group", "of", "6", "patients", "was", "normal", "."], "h": {"id": "C2930997", "name": "C2930997#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416602", "name": "C1416602#ent", "pos": [16, 17]}}
{"token": ["TGF-beta", "up-regulates", "nox4", "and", "increases", "the", "levels", "of", "C0139880#ent", "<e1>", "a", "known", "regulator", "of", "both", "Nox1", "and", "C3811755#ent", "<e2>", ",", "in", "a", "TbetaR-I-dependent", "manner", "."], "h": {"id": "C0139880", "name": "C0139880#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3811755", "name": "C3811755#ent", "pos": [17, 18]}}
{"token": ["The", "proliferation", "of", "EoL-1", "cells", "and", "expression", "of", "C0086661#ent", "<e1>", "were", "also", "inhibited", "by", "the", "C0169101#ent", "<e2>", "inhibitor", "U0126", "and", "JNK", "inhibitor", "SP600125", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [15, 16]}}
{"token": ["Enzymatic", "assays", "TA0175", "revealed", "that", "this", "enzyme", "catalyzed", "the", "dephosphorylation", "of", "C1418520#ent", "<e1>", "in", "vitro", "similar", "kinetic", "properties", "seen", "for", "C3814453#ent", "<e2>"], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3814453", "name": "C3814453#ent", "pos": [20, 21]}}
{"token": ["Mutants", "altered", "in", "the", "pgpB", "locus", "inactivated", "most", "of", "the", "residual", "C1418520#ent", "<e1>", "phosphatase", "activity", "present", "in", "single-step", "C3814453#ent", "<e2>", "mutants", ",", "and", "the", "level", "of", "phosphatidic", "acid", "phosphatase", "also", "reduced", "20-fold", "."], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3814453", "name": "C3814453#ent", "pos": [18, 19]}}
{"token": ["The", "anaerobically", "expressed", "fumarate", "reductase", "aerobically", "expressed", "C0038615#ent", "<e1>", "Escherichia", "coli", "two", "different", "classes", "of", "succinate", ":", "C1136197#ent", "<e2>", "SQR", ")", ",", "often", "termed", "respiratory", "complex", "II"], "h": {"id": "C0038615", "name": "C0038615#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [17, 18]}}
{"token": ["C0242708#ent", "<e1>", "confer", "greater", "benefits", "when", "combined", "with", "the", "C0003376#ent", "<e2>", "methotrexate", "."], "h": {"id": "C0242708", "name": "C0242708#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003376", "name": "C0003376#ent", "pos": [9, 10]}}
{"token": ["C1413105#ent", "<e1>", "CaMKK", ")", "and", "C0812228#ent", "<e2>", "are", "two", "multifunctional", "kinases", "in", "many", "cellular", "responses"], "h": {"id": "C1413105", "name": "C1413105#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [5, 6]}}
{"token": ["In", "a", "culture", "of", "human", "seminiferous", "tubules", "C1423502#ent", "<e1>", "inhibited", "germ", "cell", "apoptosis", ",", "suppressed", "both", "nuclear", "factor", "kappaB", "C1417708#ent", "<e2>", ")", "DNA-binding", "activity", "expression", "of", "phosphorylated", "Akt", ",", "but", "did", "not", "affect", "activator", "protein-1", "AP-1", ")", "DNA-binding", "activity"], "h": {"id": "C1423502", "name": "C1423502#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [19, 20]}}
{"token": ["Both", "symmetrical", "and", "asymmetrical", "C1332409#ent", "<e1>", "also", "appeared", "to", "affect", "the", "ED50-value", "of", "different", "C2987634#ent", "<e2>", ",", "and", "the", "ED50-value", "of", "naloxone", "in", "antagonizing", "0.04", "mg/kg", "of", "fentanyl", "."], "h": {"id": "C1332409", "name": "C1332409#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}}
{"token": ["C0016365#ent", "<e1>", "is", "used", "in", "the", "treatment", "of", "a", "variety", "of", "C0012634#ent", "<e2>", "depression", "and", "obesity", ",", "and", "of", "cocaine", "detoxification", "or", "alcoholism", "."], "h": {"id": "C0016365", "name": "C0016365#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["These", "data", "are", "consistent", "with", "interaction", "that", "facilitates", "repair", "by", "C1417239#ent", "<e1>", "or", "APE1", "by", "association", "with", "C1366837#ent", "<e2>", "."], "h": {"id": "C1417239", "name": "C1417239#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [17, 18]}}
{"token": ["Mutations", "leading", "to", "red", "cell", "enzyme", "C0268487#ent", "<e1>", "can", "be", "associated", "with", "diverse", "phenotypes", "that", "range", "from", "C0002878#ent", "<e2>", "methemoglobinemia", ",", "polycythemia", ",", "and", "neurological", "and", "developmental", "abnormalities"], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", "to", "the", "nine", "previously", "described", "phosphoglycerate", "kinase", "C0268487#ent", "<e1>", ",", "all", "of", "which", "are", "associated", "with", "C0002878#ent", "<e2>", "the", "carriers", "of", "phosphoglycerate", "kinase", "show", "no", "overt", "clinical", "symptoms"], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [18, 19]}}
{"token": ["C3669135#ent", "<e1>", "one", "of", "the", "most", "important", "constituents", "of", "C0403719#ent", "<e2>", ",", "but", "the", "determination", "of", "oxalate", "in", "urine", "has", "not", "been", "performed", "as", "a", "routine", "laboratory", "examination"], "h": {"id": "C3669135", "name": "C3669135#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0403719", "name": "C0403719#ent", "pos": [9, 10]}}
{"token": ["The", "DNA", "strand-breaking", "activities", "of", "9", "quinolones", ",", "widely", "used", "as", "C1136254#ent", "<e1>", "suspected", "to", "induce", "C0037274#ent", "<e2>", "humans", ",", "were", "examined", "under", "irradiation", "using", "standard", "domestic", "fluorescent", "lamps", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [16, 17]}}
{"token": ["We", "report", "here", "the", "clinical", "association", "humoral", "immunologic", "modifications", "during", "C0012634#ent", "<e1>", "long-standing", "CIC", "increase", ")", "and", "C4048273#ent", "<e2>", "changes", "resembling", "atypical", "APMPPE", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4048273", "name": "C4048273#ent", "pos": [17, 18]}}
{"token": ["The", "case", "of", "evolving", "multiple", "C0000833#ent", "<e1>", "became", "symptomatic", "with", "a", "C0018979#ent", "<e2>", "the", "clinical", "and", "radiological", "signs", "of", "a", "subarachnoid", "haemorrhage", "is", "reported", "."], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018979", "name": "C0018979#ent", "pos": [11, 12]}}
{"token": ["Hepatitis", "C", "virus", "HCV", ")", "infection", "frequently", "leads", "to", "C0019189#ent", "<e1>", "cirrhosis", "of", "the", "C0023899#ent", "<e2>", "and", "has", "been", "linked", "to", "development", "of", "hepatocellular", "carcinoma"], "h": {"id": "C0019189", "name": "C0019189#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [14, 15]}}
{"token": ["The", "formulation", "of", "photocrosslinked", "C0267964#ent", "<e1>", "modified", "with", "C0067666#ent", "<e2>", "hydrogel", "as", "an", "adhesive", "for", "a", "dermatological", "patch", "optimized", "based", "on", "the", "simultaneous", "optimization", "technique"], "h": {"id": "C0267964", "name": "C0267964#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0067666", "name": "C0067666#ent", "pos": [8, 9]}}
{"token": ["This", "photoreactive", "C0267964#ent", "<e1>", "was", "applied", "to", "the", "surface", "of", "the", "C0067666#ent", "<e2>", "gels", "to", "provide", "both", "a", "cell", "adhesive", "layer", "a", "photoreactive", "handle", "for", "further", "NGF", "immobilization", "."], "h": {"id": "C0267964", "name": "C0267964#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0067666", "name": "C0067666#ent", "pos": [11, 12]}}
{"token": ["A", "photopolymerization", "technique", "was", "applied", "in", "the", "preparation", "of", "a", "hydrogel", "composed", "of", "polyacrylic", "acid", "C0267964#ent", "<e1>", ")", "in", "which", "2-hydroxyethyl", "methacrylate", "C0067666#ent", "<e2>", ")", "was", "modified", "."], "h": {"id": "C0267964", "name": "C0267964#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0067666", "name": "C0067666#ent", "pos": [22, 23]}}
{"token": ["Increased", "risks", "were", ",", "in", "addition", ",", "found", "for", "tetracyclines", ",", "C0028156#ent", "<e1>", "and", "a", "history", "of", "C0155877#ent", "<e2>", "a", "decreased", "risk", "found", "for", "rheumatic", "symptoms"], "h": {"id": "C0028156", "name": "C0028156#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0155877", "name": "C0155877#ent", "pos": [17, 18]}}
{"token": ["We", "studied", "11", "children", "with", "C0011615#ent", "<e1>", "20", "children", "with", "C0155877#ent", "<e2>", "18", "adults", "with", "C0011615#ent", "<e1>", "38", "healthy", "age", "controls", "aged", "4", "-", "51", "years", "."], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0155877", "name": "C0155877#ent", "pos": [10, 11]}}
{"token": ["In", "order", "to", "provide", "C1291208#ent", "<e1>", "as", "a", "substrate", "for", "C0001899#ent", "<e2>", "glycolytic", "activity", "is", "increased", "in", "the", "presence", "of", "exogenous", "alanine", "."], "h": {"id": "C1291208", "name": "C1291208#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001899", "name": "C0001899#ent", "pos": [10, 11]}}
{"token": ["In", "some", "patients", ",", "C0860207#ent", "<e1>", "represent", "an", "IgA", "class", "response", "to", "the", "C3539739#ent", "<e2>", "1", "."], "h": {"id": "C0860207", "name": "C0860207#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539739", "name": "C3539739#ent", "pos": [13, 14]}}
{"token": ["We", "have", "identified", "two", "proteins", "that", "undergo", "marked", "changes", "in", "tyrosine", "phosphorylation", "these", "processes", ":", "a", "42-kDa", "protein", "to", "mitogen-activated", "protein", "kinase", "C0769224#ent", "<e1>", "MAP", "kinase", "and", "a", "34-kDa", "protein", "identical", "or", "related", "to", "C0080054#ent", "<e2>", "."], "h": {"id": "C0769224", "name": "C0769224#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [34, 35]}}
{"token": ["C1422011#ent", "<e1>", "is", "most", "similar", "to", "a", "C0077678#ent", "<e2>", "Caenorhabditis", "elegans", "suggesting", "that", "this", "gene", "has", "been", "conserved", "throughout", "evolution", "."], "h": {"id": "C1422011", "name": "C1422011#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [7, 8]}}
{"token": ["C0009450#ent", "<e1>", "only", "be", "isolated", "from", "C57BL/6", "mice", "C0752235#ent", "<e2>", "although", "viral", "antigen", "be", "detected", "in", "most", "mice", "whether", "symptomatic", "or", "not", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [8, 9]}}
{"token": ["A", "total", "of", "26", "children", "with", "C0009450#ent", "<e1>", "the", "absence", "of", "C0752235#ent", "<e2>", "11", "children", "without", "signs", "of", "a", "peripheral", "infection", "without", "C0752235#ent", "<e2>", "as", "controls", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [11, 12]}}
{"token": ["Mammalian", "cells", "C0085748#ent", "<e1>", "similar", "to", "CT", "and", "an", "ADP-ribosyl(arginine)protein", "hydrolase", "C1412252#ent", "<e2>", ")", ",", "which", "cleaves", "the", "ADP-ribose-(arginine)protein", "bond", ",", "regenerating", "native", "protein", "and", "completing", "an", "ADP-ribosylation", "cycle"], "h": {"id": "C0085748", "name": "C0085748#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412252", "name": "C1412252#ent", "pos": [11, 12]}}
{"token": ["In", "the", "presence", "of", "(", "D-Lys(3))-GHRP-6", ",", "a", "specific", "C1516869#ent", "<e1>", "GHS-R", ",", "the", "increase", "in", "[Ca(2+)](i", ")", "evoked", "by", "C1825346#ent", "<e2>", "was", "decreased", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1825346", "name": "C1825346#ent", "pos": [20, 21]}}
{"token": ["The", "clinical", "and", "genetic", "features", "discussed", "for", "the", "C0029896#ent", "<e1>", "with", "prominent", "C0003405#ent", "<e2>", "signs", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003405", "name": "C0003405#ent", "pos": [12, 13]}}
{"token": ["Clinical", "and", "biochemical", "findings", "in", "a", "patient", "affected", "by", "C0268273#ent", "<e1>", "presenting", "as", "progressive", "C0393593#ent", "<e2>", "and", "mental", "deterioration", "are", "reported", "."], "h": {"id": "C0268273", "name": "C0268273#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "Rabphilin-3A", "shows", "a", "weak", "activity", "to", "stimulate", "the", "GTPase", "activity", "C0245959#ent", "<e1>", "and", "a", "strong", "activity", "to", "inhibit", "the", "C0245959#ent", "<e1>", "GTPase-activating", "protein", "C0018296#ent", "<e1>", "activity", "of", "C0245959#ent", "<e1>", "."], "h": {"id": "C0245959", "name": "C0245959#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [25, 26]}}
{"token": ["C0245959#ent", "<e1>", "is", "a", "small", "C0018296#ent", "<e2>", "that", "binds", "selectively", "to", "secretory", "vesicles", "switches", "between", "active", ",", "GTP-bound", "and", "inactive", ",", "GDP-bound", "conformations", "."], "h": {"id": "C0245959", "name": "C0245959#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [5, 6]}}
{"token": ["The", "increase", "in", "phosphorylation", "was", "critically", "dependent", "on", "external", "Ca(2+)", "on", "the", "presence", "of", "C0245959#ent", "<e1>", ",", "a", "small", "C0018296#ent", "<e2>", "that", "recruits", "rabphilin", "to", "synaptic", "vesicles"], "h": {"id": "C0245959", "name": "C0245959#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [19, 20]}}
{"token": ["The", "rat", "phenylethanolamine", "N-methyltransferase", "C3541302#ent", "<e1>", ")", "C0017337#ent", "<e2>", "was", "isolated", "from", "a", "genomic", "library", "cross-hybridization", "with", "a", "bovine", "C3541302#ent", "<e1>", "cDNA", "probe"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541302", "name": "C3541302#ent", "pos": [4, 5]}}
{"token": ["In", "PC", "Cl3", "cells", ",", "a", "rat", "thyroid", "cell", "line", "angiotensin", "(", "Ang", "II", "activates", "the", "atypical", "protein", "kinase", "C-zeta", "(", "C1418928#ent", "<e1>", ")", "and", "the", "C0082529#ent", "<e2>", "ERK", ")", "pathways", "."], "h": {"id": "C1418928", "name": "C1418928#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [26, 27]}}
{"token": ["We", "isolated", "and", "characterized", "recessive", "mutations", "in", "six", "nuclear", "genes", "C1420467#ent", "<e1>", "to", "TSF6", ",", "that", "impair", "silencing", "of", "C1416829#ent", "<e2>", "and", "GAL10", "gene", "expression", "."], "h": {"id": "C1420467", "name": "C1420467#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416829", "name": "C1416829#ent", "pos": [19, 20]}}
{"token": ["Most", "significantly", ",", "mutations", "in", "all", "six", "C1420467#ent", "<e1>", "to", "TSF6", "genes", "activated", "expression", "from", "C1416829#ent", "<e2>", "and", "CYC1", "promoters", "(", "fused", "to", "lacZ", ")", "lacking", "upstream", "activating", "sequences", "."], "h": {"id": "C1420467", "name": "C1420467#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416829", "name": "C1416829#ent", "pos": [15, 16]}}
{"token": ["Isolates", "of", "N.", "gonorrhoeae", "men", "with", "C0041976#ent", "<e1>", "were", "tested", "for", "susceptibility", "to", "eight", "C1136254#ent", "<e2>", "disc", "diffusion", "Etest", "and", "agar", "dilution", "methods"], "h": {"id": "C0041976", "name": "C0041976#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [14, 15]}}
{"token": ["We", "report", "here", "that", "specific", "organic", "acids", "stationary-phase", "Escherichia", "coli", "and", "C0036117#ent", "<e1>", "killing", "by", "a", "potent", "antimicrobial", "peptide", "from", "the", "human", "C1443145#ent", "<e2>", "BPI", ")", "."], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1443145", "name": "C1443145#ent", "pos": [22, 23]}}
{"token": ["Sensitivity", "to", "C0165724#ent", "<e1>", "was", "approximately", "2-fold", "higher", "than", "that", "to", "C0010592#ent", "<e2>", "in", "most", "of", "the", "lines", "although", "not", "in", "the", "most", "sensitive", "line", ",", "COR-L88", "."], "h": {"id": "C0165724", "name": "C0165724#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "examine", "the", "levels", "of", "C0914069#ent", "<e1>", "PAF", ")", "and", "lyso-PAF", "in", "tears", "from", "experimental", "animals", "C0009766#ent", "<e2>", "AC", ")", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [22, 23]}}
{"token": ["Experimental", "observations", "C0026650#ent", "<e1>", "tremor", "and", "voluntary", "microdisplacements", "recorded", "in", "patients", "with", "Parkinson's", "disease", "C3160718#ent", "<e2>", ")", "during", "a", "simple", "visuomotor", "tracking", "task", "are", "analyzed", "."], "h": {"id": "C0026650", "name": "C0026650#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [14, 15]}}
{"token": ["C0015131#ent", "<e1>", "was", "used", "in", "eight", "patients", "to", "control", "status", "C0038220#ent", "<e2>", "which", "had", "been", "refractory", "to", "previous", "anticonvulsant", "therapy"], "h": {"id": "C0015131", "name": "C0015131#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [10, 11]}}
{"token": ["The", "role", "of", "histone", "deacetylation", "the", "glucocorticoid", "effect", "was", "studied", "by", "using", "three", "structurally", "different", "inhibitors", "of", "histone", "deacetylases", "C1422386#ent", "<e1>", ")", ":", "trichostatin", "A", "apicidin", "and", "C3658510#ent", "<e2>", "."], "h": {"id": "C1422386", "name": "C1422386#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3658510", "name": "C3658510#ent", "pos": [27, 28]}}
{"token": ["In", "patients", "with", "C2348633#ent", "<e1>", ",", "due", "to", "mutations", "in", "C0669372#ent", "<e2>", "nuclear", "factor-1beta", "diabetes", "is", "associated", "with", "pancreatic", "atrophy", "renal", "morphologic", "functional", "abnormalities", "and", "genital", "tract", "liver", "test", "abnormalities", "."], "h": {"id": "C2348633", "name": "C2348633#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}}
{"token": ["Like", "C3889696#ent", "<e1>", ",", "it", "has", "2", "C0041260#ent", "<e2>", "and", "6", "cysteines", ",", "but", "its", "COOH-terminal", "sequence", "identical", "with", "that", "of", "bGH", ":", "-Cys-Ala-Phe-OH", "."], "h": {"id": "C3889696", "name": "C3889696#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041260", "name": "C0041260#ent", "pos": [7, 8]}}
{"token": ["The", "contribution", "of", "C0024138#ent", "<e1>", "anticoagulant", "to", "the", "pathogenesis", "of", "C0242380#ent", "<e2>", "systemic", "lupus", "erythematosus", "and", "its", "possible", "relationship", "to", "pulmonary", "thromboembolic", "hypertension", "discussed", "."], "h": {"id": "C0024138", "name": "C0024138#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242380", "name": "C0242380#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "the", "largest", "subunits", ",", "the", "C1705468#ent", "<e1>", "and", "XPD", "helicases", "are", "associated", "with", "inherited", "disorders", "xeroderma", "pigmentosum", "Cockayne's", "syndrome", "and", "C1955934#ent", "<e2>", "."], "h": {"id": "C1705468", "name": "C1705468#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C1955934", "name": "C1955934#ent", "pos": [22, 23]}}
{"token": ["The", "first", "one", "is", "nucleotide", "excision", "repair", "exposure", "to", "UV", "light", "regarded", "on", "using", "examples", "of", "various", "eukaryotic", "cells", "detailed", "description", "of", "C0029896#ent", "<e1>", "to", "genetic", "defects", "this", "process", "(", "xeroderma", "pigmentosum", "C0009207#ent", "<e2>", "and", "trychotiodystrophy", ")", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [32, 33]}}
{"token": ["Lamin", "A", "mutations", "cause", "many", "C0029896#ent", "<e1>", ",", "including", "cardiomyopathies", "and", "C0009207#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [11, 12]}}
{"token": ["Sixty-nine", "patients", "with", "C0039133#ent", "<e1>", "18", "with", "treated", "C0039128#ent", "<e2>", "were", "included", "."], "h": {"id": "C0039133", "name": "C0039133#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [8, 9]}}
{"token": ["This", "review", "summarizes", "our", "current", "view", "on", "involvement", "of", "Nur77", ",", "C2983693#ent", "<e1>", ",", "and", "NOR-1", "in", "C0004153#ent", "<e2>", "discusses", "NR4A", "function", "in", "vascular", "response", "injury", "."], "h": {"id": "C2983693", "name": "C2983693#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [17, 18]}}
{"token": ["C0008809#ent", "<e1>", "was", "used", "in", "six", "patients", "whose", "C0011991#ent", "<e2>", "symptoms", "ceased", "dramatically", "within", "48", "h", "of", "commencing", "the", "antibiotic", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [8, 9]}}
{"token": ["A", "5-day", "C0008809#ent", "<e1>", "regimen", ",", "targeted", "to", "the", "most", "severe", "cases", "of", "C0011991#ent", "<e2>", "was", "highly", "effective", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "C1701412#ent", "<e1>", ",", "though", "not", "an", "C0020289#ent", "<e2>", "may", "enter", "the", "lysosomal", "trafficking", "pathway", "and", "may", "have", "evolved", "from", "a", "lysosomal", "enzyme"], "h": {"id": "C1701412", "name": "C1701412#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [10, 11]}}
{"token": ["Thus", "the", "patients", "with", "chronic", "active", "hepatitis", "cirrhosis", "of", "the", "C0023899#ent", "<e1>", "showed", "significantly", "elevated", "serum", "C1332773#ent", "<e2>", "III-peptide", "levels", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332773", "name": "C1332773#ent", "pos": [16, 17]}}
{"token": ["Collectively", ",", "these", "findings", "indicate", "that", "C1422393#ent", "<e1>", "is", "a", "tumor", "suppressor", "regulates", "and", "requires", "C0085114#ent", "<e2>", "to", "suppress", "cell", "proliferation"], "h": {"id": "C1422393", "name": "C1422393#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085114", "name": "C0085114#ent", "pos": [15, 16]}}
{"token": ["These", "results", "show", "that", "lipophilic", "D-xylose", "derivatives", "may", "serve", "as", "prototype", "molecules", "the", "development", "of", "novel", "C0020616#ent", "<e1>", "the", "treatment", "of", "C0011849#ent", "<e2>", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [21, 22]}}
{"token": ["C3G", "a", "human", "C1425376#ent", "<e1>", "Ras", "protein", "was", "mapped", "to", "human", "C0795833#ent", "<e2>", "fluorescence", "in", "situ", "hybridization", "R-banded", "chromosomes", "."], "h": {"id": "C1425376", "name": "C1425376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0795833", "name": "C0795833#ent", "pos": [11, 12]}}
{"token": ["The", "human", "C1425758#ent", "<e1>", "gene", "has", "been", "automatically", "predicted", "(", "C3539675#ent", "<e2>", ";", "GenBank", "accession", "number", ";", "however", ",", "this", "sequence", "appears", "to", "be", "incomplete", "."], "h": {"id": "C1425758", "name": "C1425758#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539675", "name": "C3539675#ent", "pos": [10, 11]}}
{"token": ["Although", "antihistamines", "are", "widely", "used", "for", "symptomatic", "treatment", "of", "seasonal", "(", "allergic", ")", "C0009443#ent", "<e1>", ",", "the", "role", "of", "histamines", "in", "the", "pathogenesis", "of", "C0009450#ent", "<e2>", "not", "clear", "."], "h": {"id": "C0009443", "name": "C0009443#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [24, 25]}}
{"token": ["Cerebral", "angiography", "the", "C0740386#ent", "<e1>", "the", "anomalous", "C0148346#ent", "<e2>", "originating", "at", "rt", "."], "h": {"id": "C0740386", "name": "C0740386#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0148346", "name": "C0148346#ent", "pos": [7, 8]}}
{"token": ["Transient-transfection", "assays", "have", "implicated", "pRb", "in", "the", "transcription", "of", "several", "C1417679#ent", "<e1>", ",", "including", "c-fos", ",", "the", "C1704829#ent", "<e2>", "c-myc", ",", "cdc-2", ",", "c-neu", ",", "and", "the", "transforming", "growth", "factor", "beta2", "gene"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704829", "name": "C1704829#ent", "pos": [17, 18]}}
{"token": ["The", "present", "study", "investigated", "the", "role", "played", "by", "C1334126#ent", "<e1>", "activity", "in", "tissue", "PMN", "infiltration", "and", "subsequent", "triggering", "of", "C0007965#ent", "<e2>", "."], "h": {"id": "C1334126", "name": "C1334126#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007965", "name": "C0007965#ent", "pos": [19, 20]}}
{"token": ["We", "subsequently", "identified", "feline", "C1314754#ent", "<e1>", "feAPOBEC3", ")", "proteins", "as", "C0003015#ent", "<e2>", "HIV-1", "particle", "infectivity", "."], "h": {"id": "C1314754", "name": "C1314754#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [10, 11]}}
{"token": ["A", "new", "series", "[", "C(n)O(m", ")", "mim][X", "]", "of", "C0020924#ent", "<e1>", "cation-based", "room", "temperature", "ionic", "liquids", "RTILs", ")", ",", "with", "C0014994#ent", "<e2>", "and", "alcohol", "functional", "groups", "on", "the", "alkyl", "side-chain", "has", "been", "prepared", "."], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014994", "name": "C0014994#ent", "pos": [20, 21]}}
{"token": ["Peripheral", "chemical", "sympathectomy", "by", "means", "of", "C0085196#ent", "<e1>", "does", "not", "influence", "the", "calorigenic", "effects", "C0012963#ent", "<e2>", ",", "when", "given", "3", "days", "after", "C0085196#ent", "<e1>", "administration", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012963", "name": "C0012963#ent", "pos": [14, 15]}}
{"token": ["Because", "either", "C0014724#ent", "<e1>", "or", "heartburn", "may", "result", "from", "transient", "lower", "esophageal", "sphincter", "relaxations", ",", "it", "has", "been", "proposed", "that", "C0014724#ent", "<e1>", "may", "be", "a", "manifestation", "of", "gastroesophageal", "reflux", "disease", "C0017168#ent", "<e1>", ")", "."], "h": {"id": "C0014724", "name": "C0014724#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [30, 31]}}
{"token": ["There", "were", "3", "cases", "of", "Fitz-Hugh-Curtis", "syndrome", "C0242172#ent", "<e1>", "PID", ")", "complications", "and", "perihepatitis", ",--", "caused", "by", "C0518948#ent", "<e2>"], "h": {"id": "C0242172", "name": "C0242172#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0518948", "name": "C0518948#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", "to", "p38", "and", "p38", "beta", "C1458133#ent", "<e1>", "fails", "to", "phosphorylate", "ATF-2", "or", "C1442514#ent", "<e2>", "does", "like", "other", "MAP", "kinases", "phosphorylate", "MBP", "."], "h": {"id": "C1458133", "name": "C1458133#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1442514", "name": "C1442514#ent", "pos": [14, 15]}}
{"token": ["In", "general", ",", "varieties", "good", "for", "a", "thick", "porridge", "preparation", "(", "\"", "t\u00f4", "\"", ")", "had", "low", "C0031428#ent", "<e1>", "content", "and", "a", "medium", "C0013591#ent", "<e2>", "activity", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0013591", "name": "C0013591#ent", "pos": [23, 24]}}
{"token": ["Acute", "otitis", "media", "C2698738#ent", "<e1>", ")", "is", "the", "most", "common", "bacterial", "C4289590#ent", "<e2>", "of", "viral", "bronchiolitis"], "h": {"id": "C2698738", "name": "C2698738#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4289590", "name": "C4289590#ent", "pos": [11, 12]}}
{"token": ["The", "reported", "dielectric", "alpha", "relaxation", "time", "tau", "shows", "certain", "deviations", "from", "the", "free-volume", "model", "which", "are", "larger", "for", "C1332713#ent", "<e1>", "than", "for", "C3273591#ent", "<e2>", "."], "h": {"id": "C1332713", "name": "C1332713#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3273591", "name": "C3273591#ent", "pos": [22, 23]}}
{"token": ["Whereas", "the", "neuritic", "APP", "is", "phosphorylated", "by", "c-Jun", "NH(2)-terminal", "kinase", "a", "pathway", "that", "is", "modulated", "by", "glycogen", "synthase", "kinase", "3beta", "the", "endosomal", "C0032999#ent", "<e1>", "in", "degenerated", "CAD", "cells", "results", "from", "activation", "of", "C1565306#ent", "<e2>"], "h": {"id": "C0032999", "name": "C0032999#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1565306", "name": "C1565306#ent", "pos": [32, 33]}}
{"token": ["The", "index", "patient", "is", "a", "23-year-old", "female", "with", "end-stage", "renal", "disease", "C2316810#ent", "<e1>", ")", "secondary", "to", "C0729502#ent", "<e2>"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [16, 17]}}
{"token": ["The", "index", "patient", "is", "a", "23-year-old", "female", "with", "C2316810#ent", "<e1>", "ESRD", ")", "secondary", "to", "C0729502#ent", "<e2>"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [14, 15]}}
{"token": ["Congenital", "thrombocytopenia", "occur", "in", "isolation", "or", "accompanied", "by", "C0013595#ent", "<e1>", "and", "immunodeficiency", ",", "as", "part", "of", "the", "C0043194#ent", "<e2>", "WAS", ")", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0043194", "name": "C0043194#ent", "pos": [17, 18]}}
{"token": ["Initially", "the", "patient", "was", "diagnosed", "with", "infective", "endocarditis", "to", "persistent", "C0015967#ent", "<e1>", ",", "history", "of", "C0026265#ent", "<e2>", "single", "positive", "culture", "and", "echocardiographic", "scan", "infective", "endocarditis"], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026265", "name": "C0026265#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", "C1419031#ent", "<e1>", "is", "needed", "for", "incorporating", "C1419034#ent", "<e2>", "into", "the", "26S", "proteasome", "that", "C1419031#ent", "<e1>", "participates", "in", "the", "assembly", "and/or", "stability", "of", "the", "26S", "proteasome"], "h": {"id": "C1419031", "name": "C1419031#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419034", "name": "C1419034#ent", "pos": [10, 11]}}
{"token": ["C0034686#ent", "<e1>", "a", "rare", "C0043528#ent", "<e2>", "by", "Streptobacillus", "moniliformis", "Spirillum", "minus", "which", "is", "characterised", "by", "fever", ",", "rash", "and", "arthritis", "."], "h": {"id": "C0034686", "name": "C0034686#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [4, 5]}}
{"token": ["C0034686#ent", "<e1>", "a", "worldwide", "C0043528#ent", "<e2>", ",", "non-reportable", "disease", "."], "h": {"id": "C0034686", "name": "C0034686#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [4, 5]}}
{"token": ["This", "group", "includes", "the", "major", "alternative", "pathway", "regulator", ",", "complement", "factor", "H", "C1538440#ent", "<e1>", ")", "and", "five", "complement", "factor", "H", "related", "proteins", "C1538441#ent", "<e2>", ")", "."], "h": {"id": "C1538440", "name": "C1538440#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1538441", "name": "C1538441#ent", "pos": [22, 23]}}
{"token": ["Our", "study", "supports", "the", "view", "that", "LPP", "is", "a", "heterogeneous", "condition", "in", "which", "C0023646#ent", "<e1>", "induce", "different", "subepidermal", "acquired", "C0085932#ent", "<e2>"], "h": {"id": "C0023646", "name": "C0023646#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085932", "name": "C0085932#ent", "pos": [19, 20]}}
{"token": ["The", "histidine", "modifying", "agent", ",", "C0048134#ent", "<e1>", "not", "inhibit", "guinea", "pig", "C1744635#ent", "<e2>", "conditions", "in", "which", "Crotalus", "adamanteus", "phospholipase", "A2", "inhibited", "80", "%", "."], "h": {"id": "C0048134", "name": "C0048134#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1744635", "name": "C1744635#ent", "pos": [11, 12]}}
{"token": ["C0085278#ent", "<e1>", "APS", ")", "is", "a", "common", "C0004364#ent", "<e2>", "manifested", "by", "vascular", "thrombosis", "fetal", "loss", "the", "presence", "of", "antiphospholipid", "antibodies"], "h": {"id": "C0085278", "name": "C0085278#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [7, 8]}}
{"token": ["The", "C1706991#ent", "<e1>", "inhibited", "the", "elastin", "hydrolysis", "by", "leukocyte", "elastase", "when", "the", "C0014442#ent", "<e2>", "and", "the", "inhibitor", "were", "simultaneously", "added", "to", "the", "substrate", "and", "after", "preliminary", "elastase", "adsorption", "on", "elastin", "."], "h": {"id": "C1706991", "name": "C1706991#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["However", ",", "unlike", "the", "fragments", "from", "C1706991#ent", "<e1>", "our", "chymotrypsin-inhibitory", "fragment", "a", "potent", "inhibitor", "of", "the", "C0014442#ent", "<e2>", "and", "was", "as", "resistant", "as", "the", "intact", "inhibitor", "to", "the", "attack", "of", "excess", "chymotrypsin", "."], "h": {"id": "C1706991", "name": "C1706991#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["The", "C4082284#ent", "<e1>", "ERK", ")", "pathway", "has", "been", "shown", "to", "regulate", "many", "C0162628#ent", "<e2>", "but", "its", "role", "during", "astrovirus", "infection", "unknown", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "C2936796#ent", "<e1>", "salmeterol", "and", "C0543495#ent", "<e2>", "on", "thromboxane", "B2", "release", "from", "human", "airway", "macrophages", "and", "peripheral", "blood", "monocytes", "been", "examined", "."], "h": {"id": "C2936796", "name": "C2936796#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [7, 8]}}
{"token": ["Of", "the", "other", "commonly", "used", "C2936796#ent", "<e1>", "fenoterol", ",", "and", "formoterol", ",", "but", "not", "C0543495#ent", "<e2>", ",", "caused", "moderate", "inhibition", "of", "neutrophil", "oxidant", "generation", "by", "a", "superoxide-scavenging", "mechanism", "."], "h": {"id": "C2936796", "name": "C2936796#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [14, 15]}}
{"token": ["Taking", "these", "effects", "into", "account", ",", "C0023863#ent", "<e1>", "is", "considerably", "more", "active", "as", "an", "C0003286#ent", "<e2>", "than", "quinpirole", "."], "h": {"id": "C0023863", "name": "C0023863#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "indicate", "that", "mRNA", "expression", "of", "C1414512#ent", "<e1>", "in", "human", "whole", "blood", "with", "C0243026#ent", "<e2>", ",", "and", "may", "be", "an", "interesting", "biomarker", "for", "predicting", "the", "onset", "of", "septic", "shock"], "h": {"id": "C1414512", "name": "C1414512#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [14, 15]}}
{"token": ["The", "focal", "adhesion", "kinase", "FAK", ")", "and", "C1430595#ent", "<e1>", "CAKbeta", ",", "PYK2", ",", "CADTK", ",", "C1335273#ent", "<e2>", ")", "are", "highly", "homologous", "FAK", "family", "members", "yet", "clearly", "have", "unique", "roles", "in", "the", "cell", "."], "h": {"id": "C1430595", "name": "C1430595#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335273", "name": "C1335273#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "whether", "EIIAB(Man", ")", "controlled", "expression", "the", "known", "virulence", "genes", "C0017772#ent", "<e1>", "(", "gtfBC", ")", "and", "fructosyltransferase", "(", "C3813144#ent", "<e2>", ")", "promoter", "fusions", "these", "genes", "were", "established", "in", "the", "wild-type", "and", "EIIAB(Man)-deficient", "strains", "."], "h": {"id": "C0017772", "name": "C0017772#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3813144", "name": "C3813144#ent", "pos": [19, 20]}}
{"token": ["2", "-", "There", "is", "no", "previsibility", "about", "the", "consequence", "of", "the", "use", "of", "C0009871#ent", "<e1>", "(", "hormonal", "and", "IUD", ")", "in", "patients", "with", "C0393718#ent", "<e2>"], "h": {"id": "C0009871", "name": "C0009871#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0393718", "name": "C0393718#ent", "pos": [23, 24]}}
{"token": ["Expression", "of", "the", "C1511576#ent", "<e1>", "p21", "correlated", "with", "C2986638#ent", "<e2>", "expression", "and", "myoblast", "differentiation", "but", "not", "with", "growth", "arrest"], "h": {"id": "C1511576", "name": "C1511576#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2986638", "name": "C2986638#ent", "pos": [8, 9]}}
{"token": ["From", "a", "functional", "point", "of", "view", ",", "sarcoid", "C3540579#ent", "<e1>", "able", "to", "respond", "to", "CXCL10", ",", "CXCL16", ",", "and", "C1366524#ent", "<e2>", "in", "migratory", "assays"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366524", "name": "C1366524#ent", "pos": [19, 20]}}
{"token": ["All", "patients", "had", "several", "metastatic", "localizations", "in", "the", "bones", ",", "initial", "high", "prostate", "specific", "antigen", "C1426033#ent", "<e1>", ")", ",", "and", "high", "acid", "AP", ")", "and", "alkaline", "phosphatase", "C3812647#ent", "<e2>", ")", "."], "h": {"id": "C1426033", "name": "C1426033#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3812647", "name": "C3812647#ent", "pos": [27, 28]}}
{"token": ["Pre-treatment", "serum", "C1426033#ent", "<e1>", "levels", "were", "also", "significantly", "higher", "in", "the", "C3812647#ent", "<e2>", "flare", "group", "(", "p", "=", "0.0010", ")", "."], "h": {"id": "C1426033", "name": "C1426033#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3812647", "name": "C3812647#ent", "pos": [11, 12]}}
{"token": ["The", "GST-rAPEN", "activity", "failed", "to", "exhibit", "any", "C0950448#ent", "<e1>", "exonuclease", "activity", "a", "characteristic", "shared", "by", "the", "major", "C0140145#ent", "<e2>", "bovine", "and", "human", "."], "h": {"id": "C0950448", "name": "C0950448#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [17, 18]}}
{"token": ["C0085826#ent", "<e1>", "a", "limited", "role", "except", "in", "the", "palliation", "of", "the", "C1848862#ent", "<e2>", "of", "erythromelalgia", "."], "h": {"id": "C0085826", "name": "C0085826#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "COX-2", "enzymatic", "inhibition", "dramatically", "reduced", "C0242957#ent", "<e1>", ",", "efficiently", "increased", "the", "cancer", "cells", "to", "C1516468#ent", "<e2>", "acted", "in", "synergy", "with", "HER-2", "inhibitor", ",", "trastuzumab", "."], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516468", "name": "C1516468#ent", "pos": [16, 17]}}
{"token": ["It", "was", "observed", "that", "C1421531#ent", "<e1>", "XO", "activities", "in", "nonischemic", "pig", "latissimus", "dorsi", "C1705360#ent", "<e2>", ")", "and", "gracilis", "muscles", "human", "C1705360#ent", "<e2>", "and", "rectus", "abdominis", "RA", ")", "muscles", "were", "<", "0.5", "mU/g", "wet", "wt", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", ":", "Cortisol", "replacement", "physiological", "daily", "doses", "increases", "C3539616#ent", "<e1>", "output", "in", "patients", "with", "C2103602#ent", "<e2>", "augmenting", "C3539616#ent", "<e1>", "pulse", "amplitude", "and", "interpulse", "levels", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2103602", "name": "C2103602#ent", "pos": [15, 16]}}
{"token": ["The", "human", "CGL-1/cytotoxic", "serine", "protease", "B", "gene", "(", "C1415380#ent", "<e1>", ";", "also", "known", "as", "C1567160#ent", "<e2>", "is", "transcriptionally", "activated", "during", "cytotoxic", "T-lymphocyte", "maturation", "."], "h": {"id": "C1415380", "name": "C1415380#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1567160", "name": "C1567160#ent", "pos": [14, 15]}}
{"token": ["The", "location", "of", "introns", "with", "respect", "to", "protein", "coding", "sequences", "the", "C1415380#ent", "<e1>", "identical", "to", "that", "of", "the", "human", "cathepsin", "G", "murine", "C1567160#ent", "<e2>"], "h": {"id": "C1415380", "name": "C1415380#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1567160", "name": "C1567160#ent", "pos": [22, 23]}}
{"token": ["Although", "it", "shows", "high", "amino", "acids", "sequence", "to", "both", "the", "vertebrate", "and", "invertebrate", "C1413697#ent", "<e1>", ",", "some", "conserved", "C3539947#ent", "<e2>", "identified", "in", "other", "CRABPs", "were", "not", "found", "in", "MeCRABP", "."], "h": {"id": "C1413697", "name": "C1413697#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [18, 19]}}
{"token": ["Previous", "studies", "revealed", "that", "human", "CHLR1", "exhibits", "DNA", "helicase-like", "activities", "that", "C1412729#ent", "<e1>", "is", "a", "C1333948#ent", "<e2>", "associates", "with", "the", "tumor", "suppressor", "BRCA1", "maintain", "genome", "integrity"], "h": {"id": "C1412729", "name": "C1412729#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333948", "name": "C1333948#ent", "pos": [15, 16]}}
{"token": ["Three", "C0086376#ent", "<e1>", "found", "in", "myelin", "--", "C1709830#ent", "<e2>", ",", "MAG", ",", "and", "OMgp", "--", "inhibit", "axon", "regeneration", "in", "vitro", "bind", "to", "the", "glycosylphosphatidylinositol-anchored", "Nogo", "receptor", "NgR", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1709830", "name": "C1709830#ent", "pos": [7, 8]}}
{"token": ["In", "patients", "for", "whom", "estrogens", "are", "contraindicated", ",", "C0221392#ent", "<e1>", "be", "treated", "with", "local", "estrogens", "and", "C1457887#ent", "<e2>", "sedatives", "such", "as", "phenobarbital", "and", "belladonna", "."], "h": {"id": "C0221392", "name": "C0221392#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [16, 17]}}
{"token": ["The", "hemodynamic", "effects", "of", "a", "single", "oral", "dose", "80", "mg", "of", "pentaerythritol", "tetranitrate", "C0030858#ent", "<e1>", ")", "were", "determined", "in", "16", "patients", "with", "C0018802#ent", "<e2>", "a", "5-hour", "period", "."], "h": {"id": "C0030858", "name": "C0030858#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [22, 23]}}
{"token": ["The", "data", "indicates", "that", "C0030858#ent", "<e1>", "produce", "beneficial", "effects", "on", "preload", "and", "afterload", "in", "C0018802#ent", "<e2>", "the", "duration", "of", "which", "may", "be", "five", "hours", "or", "longer", "."], "h": {"id": "C0030858", "name": "C0030858#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}}
{"token": ["Although", "PAH", "carcinogenicity", "is", "primarily", "mediated", "by", "the", "aryl", "hydrocarbon", "receptor", "C1706481#ent", "<e1>", ")", "through", "induction", "of", "C0534137#ent", "<e2>", ",", "it", "is", "not", "precisely", "determined", "whether", "C1706481#ent", "<e1>", "regulates", "the", "DMBA", "carcinogenesis", "in", "vivo"], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [17, 18]}}
{"token": ["The", "content", "of", "GSH", "increased", "up", "to", "about", "2-fold", "in", "PC3", "compared", "with", "LNCaP.", "Activities", "of", "glutathione", "reductase", "thioredoxin", "reductase", "and", "glutathione", "S-transferase", "C1413138#ent", "<e1>", "are", "significantly", "higher", "in", "C1366526#ent", "<e2>", "in", "LNCaP", "cells", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [29, 30]}}
{"token": ["We", "evaluated", "the", "results", "of", "united", "treatment", "thermocoagulation", "and", "C0700477#ent", "<e1>", "of", "the", "C0014175#ent", "<e2>", "among", "women", "with", "pain", "syndrome", "pelvis", "minoris"], "h": {"id": "C0700477", "name": "C0700477#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0014175", "name": "C0014175#ent", "pos": [13, 14]}}
{"token": ["The", "C1421571#ent", "<e1>", "also", "known", "as", "C1421571#ent", "<e1>", "and", "TS11", ")", "binds", "to", "AU-rich", "sequence", "elements", "in", "certain", "mRNA", "molecules", "favors", "the", "degradation", "of", "these", "mRNAs", "."], "h": {"id": "C1421571", "name": "C1421571#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421571", "name": "C1421571#ent", "pos": [1, 2]}}
{"token": ["Hantaviruses", "cause", "2", "C0043528#ent", "<e1>", "hemorrhagic", "fever", "renal", "syndrome", "HFRS", ")", "and", "C0034072#ent", "<e2>"], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [12, 13]}}
{"token": ["In", "controlling", "C0035457#ent", "<e1>", "symptoms", "mequitazine", "was", "markedly", "inferior", "to", "C0137440#ent", "<e2>", "and", "only", "slightly", "better", "than", "placebo", "."], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0137440", "name": "C0137440#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "the", "molecular", "genetic", "of", "C0009088#ent", "<e1>", "CH", ")", ",", "using", "a", "genome-wide", "scan", "and", "C1332838#ent", "<e2>"], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332838", "name": "C1332838#ent", "pos": [16, 17]}}
{"token": ["Fifty-one", "patients", "with", "an", "ICD-10", "diagnosis", "of", "schizophrenia", "and", "partial", "responders", "to", "prior", "C0040615#ent", "<e1>", "offered", "treatment", "with", "C0299792#ent", "<e2>", "as", "monotherapy", "or", "in", "combination", "their", "prior", "medication", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [13, 14]}, "relation": "therapeutic_class_of", "t": {"id": "C0299792", "name": "C0299792#ent", "pos": [18, 19]}}
{"token": ["Despite", "the", "presence", "of", "two", "potential", "caspase", "cleavage", "sites", ",", "C1414108#ent", "<e1>", "processed", "neither", "in", "vitro", "in", "vivo", "different", "C0010656#ent", "<e2>", "."], "h": {"id": "C1414108", "name": "C1414108#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [19, 20]}}
{"token": ["Analysis", "of", "the", "developmental", "regulation", "C1414069#ent", "<e1>", "in", "the", "murine", "ventral", "midbrain", "that", "the", "upregulation", "of", "C1414069#ent", "<e1>", "mRNA", "correlated", "with", "the", "generation", "of", "C0041491#ent", "<e1>", "neurons", "."], "h": {"id": "C1414069", "name": "C1414069#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041491", "name": "C0041491#ent", "pos": [24, 25]}}
{"token": ["The", "different", "sites", "of", "action", "explain", "the", "clinically", "proven", "efficacious", "combination", "of", "C0008273#ent", "<e1>", "and", "loop-diuretics", "in", "severe", "C0018802#ent", "<e2>"], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [18, 19]}}
{"token": ["C0008273#ent", "<e1>", ",", "loop", "diuretics", "aldosterone", "antagonists", "needed", "for", "acute", "and", "chronic", "treatment", "C0018802#ent", "<e2>", "alone", "or", "in", "combination", "(", "diuretic", "resistant", "heart", "failure", ")", "."], "h": {"id": "C0008273", "name": "C0008273#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["These", "data", "suggest", "that", "with", "current", "well", "planned", "antituberculosis", "chemotherapy", "program", ",", "C0041316#ent", "<e1>", "controlled", "fairly", "while", "C0275920#ent", "<e2>", "controlled", "inadequately"], "h": {"id": "C0041316", "name": "C0041316#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0275920", "name": "C0275920#ent", "pos": [17, 18]}}
{"token": ["A", "T-->C", "transition", "at", "nucleotide", "869", "of", "the", "C1705439#ent", "<e1>", "in", "a", "Leu-->Pro", "substitution", "at", "C2917660#ent", "<e2>", "of", "the", "signal", "peptide"], "h": {"id": "C1705439", "name": "C1705439#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [15, 16]}}
{"token": ["9", "of", "the", "children", "had", "C0008679#ent", "<e1>", "are", "known", "as", "predisposing", "factors", "cerebrovascular", "disease", "congenital", "heart", "disease", "7", "and", "C0022661#ent", "<e2>", "hypertension", "in", "2", ")", "."], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [19, 20]}}
{"token": ["Simultaneous", "bilateral", "rupture", "the", "quadriceps", "tendon", "rarely", "been", "reported", ";", "it", "generally", "occurs", "in", "association", "with", "C0008679#ent", "<e1>", "such", "as", "C0022661#ent", "<e2>", "obesity", ",", "diabetes", "mellitus", "secondary", "hyperparathyroidism"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [20, 21]}}
{"token": ["Seven", "infants", "developed", "C0009763#ent", "<e1>", ",", "1", "developed", "both", "C0036690#ent", "<e2>", "and", "C0009763#ent", "<e1>", ",", "1", "infant", "developed", "otitis", ",", "and", "1", "infant", "had", "a", "urinary", "tract", "infection"], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [9, 10]}}
{"token": ["Pseudomonas", "aeruginosa", "been", "associated", "with", "C0009763#ent", "<e1>", ",", "enteritis", ",", "pneumonia", ",", "C0036690#ent", "<e2>", ",", "sudden", "death", "and", "abortion", "in", "chinchillas", "."], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [12, 13]}}
{"token": ["Benzoyl", "peroxide", "preparations", "have", "proven", "to", "be", "effective", "C0035064#ent", "<e1>", "in", "the", "treatment", "of", "C0702166#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0702166", "name": "C0702166#ent", "pos": [14, 15]}}
{"token": ["Despite", "the", "conservation", "between", "the", "rho", "and", "C1705572#ent", "<e1>", ",", "the", "finding", "that", "C0538674#ent", "<e2>", "functions", "independently", "of", "the", "adenylate", "cyclase", "cAMP-dependent", "protein", "kinase", "cascade", "that", "rho", "and", "ras", "are", "involved", "in", "distinct", "biochemical", "pathways"], "h": {"id": "C1705572", "name": "C1705572#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0538674", "name": "C0538674#ent", "pos": [13, 14]}}
{"token": ["C0070122#ent", "<e1>", "may", "decrease", "mental", "stress-induced", "cardiovascular", "responses", "so", "benefit", "individuals", "with", "C0018799#ent", "<e2>", "even", "those", "with", "no", "psychiatric", "illness"], "h": {"id": "C0070122", "name": "C0070122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [12, 13]}}
{"token": ["The", "NANB", "diagnosis", "was", "based", "on", "exclusion", "of", "C0042721#ent", "<e1>", "known", "etiology", "by", "serological", "tests", "hepatitis", "A", "B", ",", "cytomegalovirus", "and", "C0149678#ent", "<e2>"], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [21, 22]}}
{"token": ["In", "a", "mouse", "model", "induction", "of", "experimental", "AA-amyloidosis", ",", "treatment", "with", "C0076092#ent", "<e1>", "was", "shown", "to", "inhibit", "the", "development", "of", "C0002726#ent", "<e2>", "."], "h": {"id": "C0076092", "name": "C0076092#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [20, 21]}}
{"token": ["Pizotifen", ",", "propranolol", ",", "flunarizine", ",", "amitriptyline", ",", "C0886883#ent", "<e1>", "topiramate", "have", "all", "been", "evaluated", "for", "efficacy", "in", "C0149931#ent", "<e2>", "prevention", "in", "double-blind", ",", "placebo-controlled", "trials"], "h": {"id": "C0886883", "name": "C0886883#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [18, 19]}}
{"token": ["The", "results", "of", "this", "study", "support", "the", "prophylactic", "efficacy", "of", "C0886883#ent", "<e1>", "ER", "in", "C0149931#ent", "<e2>", "patients", "with", "probable", "chronic", "migraine", "probable", "medication-overuse", "headache", "."], "h": {"id": "C0886883", "name": "C0886883#ent", "pos": [10, 11]}, "relation": "may_prevent", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [14, 15]}}
{"token": ["The", "results", "suggest", "that", "many", "children", "with", "a", "chronic", "or", "recurring", "C3815497#ent", "<e1>", "have", "a", "mild", "form", "of", "asthma", ",", "known", "as", "C0694548#ent", "<e2>", "which", "is", "responsive", "to", "asthma", "therapy"], "h": {"id": "C3815497", "name": "C3815497#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0694548", "name": "C0694548#ent", "pos": [22, 23]}}
{"token": ["However", ",", "other", "cases", "of", "C0010308#ent", "<e1>", "resistance", "to", "thyrotropin-releasing", "hormone", "not", "caused", "by", "mutations", "in", "the", "C1442761#ent", "<e2>"], "h": {"id": "C0010308", "name": "C0010308#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1442761", "name": "C1442761#ent", "pos": [17, 18]}}
{"token": ["From", "the", "results", "mentioned", "above", ",", "14", "of", "the", "41", "patients", "with", "C1705998#ent", "<e1>", "had", "pan-pituitary", "hormones", "LH", ",", "C0016424#ent", "<e2>", ",", "TSH", ",", "ACTH", ")", "deficiency", ",", "only", "one", "had", "isolated", "growth", "hormone", "deficiency"], "h": {"id": "C1705998", "name": "C1705998#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [19, 20]}}
{"token": ["C0040156#ent", "<e1>", "is", "one", "of", "the", "most", "common", "C0014130#ent", "<e2>", "affecting", "approximately", "2", "%", "of", "the", "adult", "population", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [8, 9]}}
{"token": ["It", "is", "concluded", "that", "the", "cerebral", "vasodilating", "and", "peripheral", "vasoconstricting", "effects", "of", "C1421143#ent", "<e1>", "are", "not", "mediated", "by", "C0356622#ent", "<e2>", "."], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [18, 19]}}
{"token": ["Patients", "(", "n=305", ")", "suffering", "from", "different", "bacterial", "infections", "serious", "respiratory", "tract", "disease", "C0149514#ent", "<e1>", ",", "gastrointestinal", "tract", "infections", "urinary", "tract", "infection", "cellulites", "and", "C0025297#ent", "<e2>", ")", "were", "enrolled", "."], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [24, 25]}}
{"token": ["Our", "results", "suggest", "that", "C0284941#ent", "<e1>", "may", "play", "a", "role", "in", "reduction", "of", "craving", "for", "C0001975#ent", "<e2>", "after", "6", "weeks", "of", "treatment", "."], "h": {"id": "C0284941", "name": "C0284941#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [15, 16]}}
{"token": ["Ascorbic", "acid", "not", "protect", "the", "RBC", "from", "a", "patient", "with", "C1387532#ent", "<e1>", "to", "G6PDTorrance", "from", "Heinz", "body", "formation", "suggesting", "that", "an", "intact", "C2697656#ent", "<e2>", "is", "necessary", "for", "ascorbic", "acid", "express", "its", "antioxidant", "properties", "."], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "the", "inhibitory", "effect", "of", "PKC", "on", "C3888088#ent", "<e1>", "chemotaxis", "was", "completely", "reversed", "by", "cAMP", "or", "C0243459#ent", "<e2>"], "h": {"id": "C3888088", "name": "C3888088#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243459", "name": "C0243459#ent", "pos": [17, 18]}}
{"token": ["These", "cells", "produce", "IL-17", "(", "also", "called", "C1825592#ent", "<e1>", ")", "and", "IL-17F", ",", "two", "most", "C1512488#ent", "<e2>", "cytokines", "sharing", "similar", "regulations", "."], "h": {"id": "C1825592", "name": "C1825592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [15, 16]}}
{"token": ["C1706351#ent", "<e1>", "from", "FMLP-activated", ",", "adherent", "PMNs", "phosphorylated", "paxillin-glutathione", "S-transferase", "suggesting", "that", "C1419150#ent", "<e2>", "is", "a", "substrate", "for", "C1706351#ent", "<e1>", "in", "vivo"], "h": {"id": "C1706351", "name": "C1706351#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419150", "name": "C1419150#ent", "pos": [12, 13]}}
{"token": ["Diagnosis", "of", "C0270999#ent", "<e1>", "or", "lens", "induced", "uveitis", ")", ",", "a", "rare", "C0004364#ent", "<e2>", "is", "difficult", "due", "to", "variable", "clinical", "presentation"], "h": {"id": "C0270999", "name": "C0270999#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "C0291771#ent", "<e1>", "appears", "promising", "in", "the", "treatment", "of", "C0000737#ent", "<e2>", "discomfort", "and", "normalising", "of", "bowel", "function", "patients", "with", "non-constipated", "IBS", "."], "h": {"id": "C0291771", "name": "C0291771#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [10, 11]}}
{"token": ["During", "12", "weeks", "of", "treatment", ",", "C0291771#ent", "<e1>", "was", "shown", "to", "elicit", "significant", "relief", "of", "C0000737#ent", "<e2>", "discomfort", "compared", "with", "placebo", "or", "mebeverine", "in", "female", "IBS", "patients", "with", "diarrhea", "."], "h": {"id": "C0291771", "name": "C0291771#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [15, 16]}}
{"token": ["Clinicians", "prescribing", "C0291771#ent", "<e1>", "should", "be", "aware", "of", "this", "potential", "side", "effect", "unexplained", "C0000737#ent", "<e2>", "jaundice", ",", "or", "abnormal", "liver", "biochemistries", "encountered", "in", "a", "treated", "patient", "."], "h": {"id": "C0291771", "name": "C0291771#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [13, 14]}}
{"token": ["Specifically", ",", "a", "C1416809#ent", "<e1>", "Raf-1", "kinase", "RafC", ";", "residues", "295", "648", "of", "human", "C0139905#ent", "<e2>", ")", "interacted", "strongly", "with", "phosphatidic", "acid"], "h": {"id": "C1416809", "name": "C1416809#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "the", "expression", "of", "GKLF", "(", "gut-enriched", "Kr\u00fcppel-like", "factor", ",", "a", "recently", "identified", "C2826562#ent", "<e1>", "in", "mice", "during", "development", "using", "the", "C0035542#ent", "<e2>"], "h": {"id": "C2826562", "name": "C2826562#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [22, 23]}}
{"token": ["Activation", "of", "ERK1/2", "resulted", "in", "induction", "of", "c-jun", ",", "junB", ",", "and", "C1706383#ent", "<e1>", "expression", ",", "whereas", "activation", "of", "C1705633#ent", "<e2>", "alone", "had", "no", "effect"], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [19, 20]}}
{"token": ["The", "relative", "intensities", "of", "the", "different", "TLC", "C0015230#ent", "<e1>", "provide", "some", "information", "on", "the", "formation", "of", "the", "C1136365#ent", "<e2>"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [17, 18]}}
{"token": ["The", "C0002085#ent", "<e1>", "often", "been", "found", "associated", "with", "increased", "risk", "of", "C1956346#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}}
{"token": ["Low", "PON1", "enzyme", "activity", "or", "specific", "C0002085#ent", "<e1>", "polymorphisms", "seem", "to", "be", "associated", "with", "risk", "of", "developing", "C1956346#ent", "<e2>", "acute", "ischemic", "stroke", "AIS", ")", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [17, 18]}}
{"token": ["The", "antirheumatic", "drugs", "indomethacin", ",", "C0012091#ent", "<e1>", ",", "D-penicillamine", ",", "auranofin", ",", "and", "C0055461#ent", "<e2>", "support", "the", "formation", "of", "DNA", "single", "strand-breaks"], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [13, 14]}}
{"token": ["A", "similar", "experimental", "approach", "be", "used", "for", "other", "C0029896#ent", "<e1>", "caused", "by", "conformational", "change", "disease", "proteins", "including", "C0033164#ent", "<e2>", ",", "Alzheimer's", "and", "Parkinson's", "diseases"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033164", "name": "C0033164#ent", "pos": [17, 18]}}
{"token": ["The", "interaction", "between", "plasma", "C1424250#ent", "<e1>", "and", "its", "platelet", "receptor", "examined", "in", "45", "patients", "with", "C3273872#ent", "<e2>", "and", "36", "age-", "and", "sex-matched", "control", "subjects"], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [15, 16]}}
{"token": ["Treatment", "of", "C0020503#ent", "<e1>", "the", "osteodystrophy", "of", "predialysis", "chronic", "renal", "failure", "C1366488#ent", "<e2>", ")", "with", "1,25(OH)2D3", "has", "been", "advocated", "by", "several", "authors", ",", "but", "also", "opposed", "by", "others", "for", "alleged", "renal", "toxicity"], "h": {"id": "C0020503", "name": "C0020503#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366488", "name": "C1366488#ent", "pos": [11, 12]}}
{"token": ["These", "derangements", "were", "attributed", "to", "the", "C0020503#ent", "<e1>", "C1366488#ent", "<e2>", ",", "since", "prior", "parathyroidectomy", "in", "C1366488#ent", "<e2>", "rats", "reversed", "these", "abnormalities", "and", "PTH", "administration", "to", "normal", "rats", "reproduced", "them", "."], "h": {"id": "C0020503", "name": "C0020503#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366488", "name": "C1366488#ent", "pos": [8, 9]}}
{"token": ["Malignant", "lymphomas", "be", "sequelae", "of", "long-term", "C0020209#ent", "<e1>", "are", "not", "always", "preceded", "by", "the", "well-known", "reversible", "C0497156#ent", "<e2>"], "h": {"id": "C0020209", "name": "C0020209#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0497156", "name": "C0497156#ent", "pos": [16, 17]}}
{"token": ["Pregnant", "women", "with", "acute", "viral", "hepatitis", "VH", ")", "and", "those", "with", "pregnancy", "associated", "acute", "liver", "disease", "PAALD", ")", "including", "C4025020#ent", "<e1>", "pregnancy", ",", "hemolysis", "elevated", "liver", "enzyme", "C0272302#ent", "<e2>", "with", "similar", "clinical", "features", "and", "liver", "tests", "abnormalities", "."], "h": {"id": "C4025020", "name": "C4025020#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0272302", "name": "C0272302#ent", "pos": [27, 28]}}
{"token": ["The", "enzyme", "has", "broad", "substrate", "specificity", "towards", "various", "C1417772#ent", "<e1>", "esters", "and", "short", "acyl", "chain", "triacylglycerols", "as", "C0077025#ent", "<e2>", "(", "C4:0", ")", "."], "h": {"id": "C1417772", "name": "C1417772#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0077025", "name": "C0077025#ent", "pos": [17, 18]}}
{"token": ["The", "only", "side", "effects", "C0072916#ent", "<e1>", "were", "increased", "bowel", "sounds", "slight", ",", "transient", "sounds", "of", "C2364135#ent", "<e2>", "."], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [15, 16]}}
{"token": ["C0019104#ent", "<e1>", "such", "as", "C0023092#ent", "<e2>", "yellow", "fever", "cause", "tens", "of", "thousands", "of", "deaths", "annually", "outside", "the", "Netherlands", "."], "h": {"id": "C0019104", "name": "C0019104#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0023092", "name": "C0023092#ent", "pos": [4, 5]}}
{"token": ["Available", "evidence", "suggests", "that", "angiotensin-converting", "enzyme", "inhibitor", "changes", "in", "the", "Hippuran", "or", "C1704877#ent", "<e1>", "renogram", "are", "predictive", "of", "reversible", "renovascular", "hypertension", "the", "presence", "of", "C0035078#ent", "<e2>"], "h": {"id": "C1704877", "name": "C1704877#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [24, 25]}}
{"token": ["Study", "has", "been", "undertaken", "to", "determine", "the", "stability", "of", "four", "C0005064#ent", "<e1>", ":", "clonazepam", ",", "midazolam", ",", "flunitrazepam", "and", "C0029997#ent", "<e2>", "in", "whole", "blood", "samples"], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [10, 11]}, "relation": "chemical_structure_of", "t": {"id": "C0029997", "name": "C0029997#ent", "pos": [19, 20]}}
{"token": ["It", "appears", "that", "C0005064#ent", "<e1>", "such", "as", "C0029997#ent", "<e2>", "and", "lorazepam", ",", "are", "the", "treatment", "of", "choice", "for", "short-term", "symptoms", "of", "geriatric", "anxiety"], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [3, 4]}, "relation": "chemical_structure_of", "t": {"id": "C0029997", "name": "C0029997#ent", "pos": [7, 8]}}
{"token": ["The", "C0005064#ent", "<e1>", "detected", "included", "diazepam", ",", "nordiazepam", ",", "temazepam", ",", "C0029997#ent", "<e2>", ",", "nitrazepam", ",", "and", "lorazepam", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0029997", "name": "C0029997#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "all", "members", "of", "the", "C0310298#ent", "<e1>", "family", "are", "inhibited", "by", "C0006864#ent", "<e2>", "and", "local", "anesthetics", "and", "TASK-3", "is", "selectively", "inhibited", "by", "ruthenium", "red"], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006864", "name": "C0006864#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "age-3", "EF", "mediated", "relations", "between", "C1704858#ent", "<e1>", "verbal", "ability", "and", "C3537324#ent", "<e2>", "problem", "behaviors"], "h": {"id": "C1704858", "name": "C1704858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3537324", "name": "C3537324#ent", "pos": [13, 14]}}
{"token": ["To", "develop", "an", "allele-specific", "polymerase", "chain", "reaction", "diagnostic", "test", "the", "mutation", "in", "the", "cyclic", "guanosine", "monophosphate", "phosphodiesterase", "alpha", "subunit", "gene", "PDE6A", ")", "that", "causes", "the", "C3890224#ent", "<e1>", "form", "of", "progressive", "retinal", "atrophy", "C3669212#ent", "<e2>", ")", "in", "Cardigan", "Welsh", "Corgis"], "h": {"id": "C3890224", "name": "C3890224#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C3669212", "name": "C3669212#ent", "pos": [32, 33]}}
{"token": ["The", "most", "common", "causes", "of", "vision", "impairment", "age-related", "macular", "degeneration", "C0025741#ent", "<e1>", ")", ",", "glaucoma", ",", "cataract", ",", "and", "C0011884#ent", "<e2>"], "h": {"id": "C0025741", "name": "C0025741#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [19, 20]}}
{"token": ["We", "evaluated", "gonadal", "function", "18", "female", "and", "eight", "male", "patients", "with", "C0268151#ent", "<e1>", "due", "to", "C0268151#ent", "<e1>", "it", "was", "normal", "in", "the", "males", ",", "but", "12", "females", "had", "signs", "of", "hypergonadotropic", "hypogonadism"], "h": {"id": "C0268151", "name": "C0268151#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0268151", "name": "C0268151#ent", "pos": [11, 12]}}
{"token": ["C0524889#ent", "<e1>", "stimulation", "triggered", "a", "physical", "association", "the", "nonreceptor", "protein", "tyrosine", "kinase", "Fyn", "and", "the", "C1334148#ent", "<e2>", ",", "which", "induced", "tyrosine", "phosphorylation", "the", "C1334148#ent", "<e2>", "."], "h": {"id": "C0524889", "name": "C0524889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334148", "name": "C1334148#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "clinicopathologic", "study", "intractable", "C1449563#ent", "<e1>", "a", "teenaged", "patient", "who", "had", "features", "of", "C0028326#ent", "<e2>"], "h": {"id": "C1449563", "name": "C1449563#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028326", "name": "C0028326#ent", "pos": [15, 16]}}
{"token": ["This", "increase", "was", "inhibited", "by", "3-methoxybenzamide", "(", "a", "competitive", "inhibitor", "of", "C1538577#ent", "<e1>", "but", "was", "not", "affected", "significantly", "by", "C1516035#ent", "<e2>", "."], "h": {"id": "C1538577", "name": "C1538577#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1516035", "name": "C1516035#ent", "pos": [19, 20]}}
{"token": ["C1421222#ent", "<e1>", "is", "the", "largest", "C1305923#ent", "<e2>", "yet", "described", "(", "relative", "molecular", "mass", "3", "x", "10(6", ")", ";", "refs", "1", ",", "2", ")", "and", "an", "abundant", "protein", "of", "striated", "muscle"], "h": {"id": "C1421222", "name": "C1421222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [5, 6]}}
{"token": ["Then", "the", "binding", "of", "biotinylated", "C1421222#ent", "<e1>", "to", "these", "C1305923#ent", "<e2>", "was", "detected", "by", "using", "the", "avidinbiotin-peroxidase", "method", "."], "h": {"id": "C1421222", "name": "C1421222#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [9, 10]}}
{"token": ["In", "colon", "cancer", "the", "formation", "and", "progression", "of", "precancerous", "lesions", "like", "aberrant", "crypt", "foci", "polyps", "is", "associated", "with", "up-regulation", "of", "C1565860#ent", "<e1>", "(", "COX-2", ")", ",", "inducible", "nitric", "oxide", "synthase", "iNOS", ")", "and", "hydroxy", "methyl", "glutaryl", "CoA", "reductase", "C0020374#ent", "<e2>", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [38, 39]}}
{"token": ["Neonatal", "C0409974#ent", "<e1>", "an", "uncommon", "C0004364#ent", "<e2>", "distinctive", "cutaneous", "findings", "."], "h": {"id": "C0409974", "name": "C0409974#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [5, 6]}}
{"token": ["Left", "ventricular", "endomyocardial", "biopsy", "indicated", "for", "C0012634#ent", "<e1>", "that", "predominantly", "involve", "the", "left", "side", "of", "the", "heart", ",", "including", "left", "heart", "irradiation", "C0014117#ent", "<e2>", "infants", ",", "endomyocardial", "fibrosis", "and", "scleroderma", "heart", "disease", "and", "when", "right", "ventricular", "biopsy", "unsuccessful", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014117", "name": "C0014117#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "when", "we", "measured", "activities", "of", "certain", "liver", "drug", "enzymes", ",", "it", "was", "found", "that", "C0008783#ent", "<e1>", "significantly", "inhibited", "C0003039#ent", "<e2>", "aminopyrine-N-demethylase", "by", "43", "%", "and", "65", "%", ",", "respectively", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003039", "name": "C0003039#ent", "pos": [21, 22]}}
{"token": ["Seven", "days", "after", "wounding", ",", "the", "histidine-sufficient", "animals", "had", "greater", "regenerative", "skin-breaking", "strength", ",", "C0009325#ent", "<e1>", "deposition", ",", "and", "tissue", "concentrations", "free", "histidine", "C3495555#ent", "<e2>", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3495555", "name": "C3495555#ent", "pos": [23, 24]}}
{"token": ["Diagnosis", "of", "C0030783#ent", "<e1>", "is", "difficult", "in", "the", "absence", "of", "the", "C0037284#ent", "<e2>", "and", "is", "often", "facilitated", "by", "the", "presence", "of", "characteristic", "ones"], "h": {"id": "C0030783", "name": "C0030783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [11, 12]}}
{"token": ["The", "amount", "of", "C0040085#ent", "<e1>", "expression", "in", "tumor", "tissues", "directly", "proportional", "to", "the", "content", "of", "C1366824#ent", "<e2>"], "h": {"id": "C0040085", "name": "C0040085#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366824", "name": "C1366824#ent", "pos": [15, 16]}}
{"token": ["Three", "polymorphisms", "in", "the", "5", "'", "and", "3", "'", "untranslated", "regions", "5'UTR", "and", "3'UTR", ")", "of", "the", "C0040085#ent", "<e1>", "been", "shown", "to", "influence", "C1366824#ent", "<e2>", "expression", "."], "h": {"id": "C0040085", "name": "C0040085#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366824", "name": "C1366824#ent", "pos": [23, 24]}}
{"token": ["Recent", "reports", "have", "shown", "that", "Tat", "can", "also", "interact", "with", "the", "multisubunit", "transcription", "factor", "TFIIH", "complex", "increase", "the", "phosphorylation", "of", "C1335071#ent", "<e1>", "by", "the", "C0255652#ent", "<e2>", "CAK", ")", "complex", "associated", "with", "core", "TFIIH", "."], "h": {"id": "C1335071", "name": "C1335071#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0255652", "name": "C0255652#ent", "pos": [24, 25]}}
{"token": ["Severe", ",", "recalcitrant", "hypocalcemia", "and", "C0342635#ent", "<e1>", "complicate", "parathyroidectomy", "in", "C2316810#ent", "<e2>", "patients", "."], "h": {"id": "C0342635", "name": "C0342635#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [10, 11]}}
{"token": ["The", "analysis", "of", "correlations", "between", "the", "parameters", "of", "five", "C3541394#ent", "<e1>", "under", "study", "(", "lymphocyte", "succinic", "dehydrogenase", "C1335057#ent", "<e2>", "lymphocyte", "non-specific", "esterase", ",", "myeloperoxidase", ",", "neutrophil", "alkaline", "phosphatase", "and", "enzymatic", "rosette", "parameters", "has", "been", "made", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335057", "name": "C1335057#ent", "pos": [17, 18]}}
{"token": ["No", "IgG", "molecules", "were", "detected", "against", "phosphorylated", "proteins", "the", "sera", "of", "C0026769#ent", "<e1>", "patients", ",", "while", "multiple", "C0031686#ent", "<e2>", "were", "recognized", "by", "IgG", "molecules", "of", "SLE", "patients", "in", "immunoprecipitation", "experiments"], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [17, 18]}}
{"token": ["After", "fibrate", "administration", "histologically", "a", "hypertrophy", ",", "an", "C1306759#ent", "<e1>", ",", "a", "reduced", "C0002245#ent", "<e2>", "content", "and", "also", "hepatocyteapoptosis", "were", "observed", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [13, 14]}}
{"token": ["Together", "with", "signs", "of", "extracerebral", "vascular", "involvement", "known", "from", "earlier", "reports", "this", "finding", "points", "to", "C2733158#ent", "<e1>", "as", "an", "important", "pathogenic", "mechanism", "in", "C0796126#ent", "<e2>"], "h": {"id": "C2733158", "name": "C2733158#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [23, 24]}}
{"token": ["The", "Nf2-encoded", "protein", ",", "merlin", ",", "is", "related", "to", "the", "ERM", "(", "ezrin", ",", "radixin", ",", "and", "C1417371#ent", "<e1>", ")", "family", "of", "membrane", ":", "C1823247#ent", "<e2>"], "h": {"id": "C1417371", "name": "C1417371#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1823247", "name": "C1823247#ent", "pos": [24, 25]}}
{"token": ["In", "11", "children", "one", "or", "more", "extrahepatic", "diseases", "present", ",", "including", "type", "1", "diabetes", "vitiligo", ",", "glomerulonephritis", ",", "C0002880#ent", "<e1>", "hypoglycemia", "with", "hyperinsulinism", ",", "autoimmune", "thyroiditis", "chronic", "mucocutaneous", "candidiasis", "C0020626#ent", "<e2>", ",", "and", "multiple", "cutaneous", "visceral", "telangiectasias"], "h": {"id": "C0002880", "name": "C0002880#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020626", "name": "C0020626#ent", "pos": [29, 30]}}
{"token": ["Because", "MICS", "leads", "to", "a", "low", "body", "mass", "index", "C0151718#ent", "<e1>", ",", "hypocreatininemia", ",", "and", "C0598608#ent", "<e2>", ",", "a", "\"", "reverse", "epidemiology", "of", "cardiovascular", "risks", "can", "occur", "in", "dialysis", "patients", "."], "h": {"id": "C0151718", "name": "C0151718#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0598608", "name": "C0598608#ent", "pos": [15, 16]}}
{"token": ["The", "parallelism", "between", "the", "growth", "assay", "the", "C1704862#ent", "<e1>", "activity", "assay", "the", "involvement", "of", "C1704862#ent", "<e1>", "activity", "in", "the", "pathway", "of", "the", "mitogenic", "effect", "C1522505#ent", "<e1>", "."], "h": {"id": "C1704862", "name": "C1704862#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1522505", "name": "C1522505#ent", "pos": [24, 25]}}
{"token": ["We", "evaluated", "the", "contribution", "of", "a", "nucleoside", "transporter", "NT", ")", "consisting", "of", "an", "equilibrative", "NT", "ENT", ")", "and", "a", "C3272518#ent", "<e1>", "CNT", ")", "to", "the", "uptake", "of", "C1705396#ent", "<e2>", "and", "DOX", "by", "mouse", "Ehrlich", "ascites", "carcinoma", "cells"], "h": {"id": "C3272518", "name": "C3272518#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705396", "name": "C1705396#ent", "pos": [27, 28]}}
{"token": ["While", "HCF", "was", "present", "in", "the", "nucleus", "of", "most", "cells", ",", "in", "cells", "expressing", "C1413703#ent", "<e1>", "it", "was", "retained", "in", "the", "cytoplasm", "where", "the", "two", "C0086376#ent", "<e2>", "colocalized", "."], "h": {"id": "C1413703", "name": "C1413703#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [25, 26]}}
{"token": ["A", "novel", "missense", "mutation", "G663A", ",", "in", "exon", "5", "the", "C0002565#ent", "<e1>", "ALAS2", ")", "was", "identified", "in", "a", "Japanese", "male", "with", "C0221018#ent", "<e2>"], "h": {"id": "C0002565", "name": "C0002565#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221018", "name": "C0221018#ent", "pos": [21, 22]}}
{"token": ["This", "reaction", "entails", "the", "condensation", "of", "glycine", "with", "succinyl-coenzyme", "A", "yield", "5-aminolevulinate", ",", "carbon", "dioxide", "CoA.", "Mutations", "in", "the", "C0002565#ent", "<e1>", "to", "a", "defective", "enzyme", "and", "are", "associated", "with", "erythropoietic", "disorder", "C0221018#ent", "<e2>"], "h": {"id": "C0002565", "name": "C0002565#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0221018", "name": "C0221018#ent", "pos": [31, 32]}}
{"token": ["The", "findings", "provide", "direct", "evidence", "for", "a", "role", "of", "SCP2", "or", "a", "similar", "C0030956#ent", "<e1>", "in", "modulating", "transfer", "of", "cholesterol", "to", "the", "inner", "membrane", "site", "C1413855#ent", "<e2>"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413855", "name": "C1413855#ent", "pos": [25, 26]}}
{"token": ["Nurses", "'", "involvement", "in", "the", "treatment", "and", "management", "of", "C0015732#ent", "<e1>", "is", "set", "to", "increase", "(", "C1832586#ent", "<e2>", ",", "2001", ")", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1832586", "name": "C1832586#ent", "pos": [16, 17]}}
{"token": ["C1413702#ent", "<e1>", "phosphorylation", "was", "partly", "inhibitable", ",", "both", "by", "the", "C0001644#ent", "<e2>", "propranolol", "and", "by", "the", "alpha(1)-adrenergic", "antagonist", "prazosin", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [10, 11]}}
{"token": ["Antagonism", "of", "C1334507#ent", "<e1>", "is", "associated", "with", "inhibition", "of", "animal", "models", "C0003873#ent", "<e2>", "."], "h": {"id": "C1334507", "name": "C1334507#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}}
{"token": ["These", "C0017337#ent", "<e1>", "include", "receptor", "for", "activated", "protein", "kinase", "C", "amida", ",", "C0007427#ent", "<e2>", "calpain", "2", "calcium-independent", "receptor", "alpha-latrotoxin", ",", "monoamine", "oxidase", "B", "polyubiquitin", ",", "and", "kinesin", "light", "chain"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [12, 13]}}
{"token": ["The", "expression", "of", "several", "C0017337#ent", "<e1>", "involved", "in", "mitotic", "signal", "transduction", "as", "well", "as", "C0007427#ent", "<e2>", "L", ",", "was", "similar", "in", "both", "parental", "and", "doxorubicin", "treated", "cells", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [14, 15]}}
{"token": ["Medical", "therapy", "CRS", "may", "include", "treatment", "with", "C3539185#ent", "<e1>", ",", "antibiotics", ",", "antifungal", "agents", "antihistamines", ",", "leukotriene", "modifiers", "nasal", "decongestants", "C0040349#ent", "<e2>", ",", "and", "nasal", "irrigations"], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040349", "name": "C0040349#ent", "pos": [20, 21]}}
{"token": ["The", "C3887685#ent", "<e1>", "CYP2D6", ")", "enzyme", "metabolizes", "C0073393#ent", "<e2>", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [1, 2]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [7, 8]}}
{"token": ["A", "mixture", "model", "was", "incorporated", "due", "to", "C3887685#ent", "<e1>", "polymorphism", "of", "C0073393#ent", "<e2>", "conversion", "to", "9-hydroxyrisperidone", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [7, 8]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [11, 12]}}
{"token": ["The", "four", "most", "common", "neuro-ophthalmic", "abnormalities", "seen", "in", "mitochondrial", "disorders", "C3887709#ent", "<e1>", "ophthalmoplegia", "with", "ptosis", ",", "C0035334#ent", "<e2>", "and", "retrochiasmal", "visual", "loss"], "h": {"id": "C3887709", "name": "C3887709#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [16, 17]}}
{"token": ["During", "the", "C3543842#ent", "<e1>", "period", "of", "REM", "sleep", ",", "deviant", "stimuli", "a", "C1540206#ent", "<e2>", "and", "a", "P400", "."], "h": {"id": "C3543842", "name": "C3543842#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1540206", "name": "C1540206#ent", "pos": [12, 13]}}
{"token": ["We", "suggest", "that", "HDACIs", "might", "inhibit", "the", "expression", "of", "C0908880#ent", "<e1>", "via", "the", "suppression", "of", "the", "C1704722#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0908880", "name": "C0908880#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704722", "name": "C1704722#ent", "pos": [16, 17]}}
{"token": ["Systemic", "effects", "two", "topical", "B", "adrenergic", "blocking", "agents", "C0007299#ent", "<e1>", "and", "metipranolol", ",", "recently", "introduced", "in", "the", "treatment", "of", "C0017612#ent", "<e2>", "were", "investigated", "in", "two", "groups", "of", "10", "asthmatic", "patients", ",", "according", "to", "a", "controlled", "trial", "device"], "h": {"id": "C0007299", "name": "C0007299#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [19, 20]}}
{"token": ["Seven", "patients", "in", "the", "latter", "group", "had", "C0398623#ent", "<e1>", "five", "had", "heparin-induced", "thrombosis", "one", "had", "C0398625#ent", "<e2>", "one", "had", "polycythemia", "with", "thrombocytosis", ")", "."], "h": {"id": "C0398623", "name": "C0398623#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0398625", "name": "C0398625#ent", "pos": [15, 16]}}
{"token": ["Perioperative", "administration", "of", "fresh", "frozen", "plasma", "protein", "C", "concentrates", "might", "be", "necessary", "to", "manage", "C0398623#ent", "<e1>", "in", "a", "patient", "with", "C0398625#ent", "<e2>"], "h": {"id": "C0398623", "name": "C0398623#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0398625", "name": "C0398625#ent", "pos": [20, 21]}}
{"token": ["The", "C0243459#ent", "<e1>", "K252a", "and", "the", "C2746050#ent", "<e2>", "MTA", "abolish", "NGF-induced", ",", "but", "not", "EGF-induced", ",", "p21ras", "activation", "--", "effects", "correlated", "with", "inhibition", "only", "of", "NGF-induced", "tyrosine", "phosphorylation"], "h": {"id": "C0243459", "name": "C0243459#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2746050", "name": "C2746050#ent", "pos": [6, 7]}}
{"token": ["In", "10", "patients", "aged", "from", "26", "to", "58", "years", "suffering", "from", "C0242350#ent", "<e1>", "caused", "by", "abnormal", "C0856761#ent", "<e2>", "resection", "of", "the", "deep", "dorsal", "vein", "the", "penis", "was", "performed", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0856761", "name": "C0856761#ent", "pos": [16, 17]}}
{"token": ["While", "C0275521#ent", "<e1>", "commonly", "occurs", "in", "immunocompromised", "hosts", "C0002962#ent", "<e2>", "can", "infect", "and", "exist", "as", "a", "saprophyte", "in", "normal", "hosts", "."], "h": {"id": "C0275521", "name": "C0275521#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [8, 9]}}
{"token": ["These", "results", "indicate", "that", "C0244404#ent", "<e1>", ",", "along", "with", "at", "least", "one", "other", "non-Rab", "C1333729#ent", "<e2>", ",", "participates", "in", "presynaptic", "regulation", "in", "hippocampal", "neurons", "."], "h": {"id": "C0244404", "name": "C0244404#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333729", "name": "C1333729#ent", "pos": [14, 15]}}
{"token": ["C0052451#ent", "<e1>", "hydrolysis", "products", "could", "also", "increase", "intracellular", "C0001477#ent", "<e2>", "levels", ",", "although", "the", "pattern", "of", "rise", "was", "different", "than", "it", "appeared", "immediately", "after", "paraoxon", "administration", "."], "h": {"id": "C0052451", "name": "C0052451#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [8, 9]}}
{"token": ["C0042842#ent", "<e1>", "found", "to", "be", "responsible", "for", "one-third", "of", "acquired", "C0565822#ent", "<e2>", "preschool", "children", "."], "h": {"id": "C0042842", "name": "C0042842#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0565822", "name": "C0565822#ent", "pos": [10, 11]}}
{"token": ["These", "findings", "illustrate", "the", "importance", "of", "lifestyle", "in", "the", "development", "of", "C0011849#ent", "<e1>", "and", "in", "the", "subsequent", "occurrence", "of", "C0011881#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [19, 20]}}
{"token": ["Polymorphisms", "in", "the", "vitamin", "K-epoxide", "reductase", "complex", "subunit", "1", "gene", "C1704977#ent", "<e1>", ",", "could", "affect", "blood", "coagulation", "other", "vitamin", "K-dependent", "proteins", "such", "as", "C1412791#ent", "<e2>", "(", "bone", "Gla", "protein", "BGP", ")", "."], "h": {"id": "C1704977", "name": "C1704977#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [23, 24]}}
{"token": ["The", "subjective", "quality", "of", "life", "C0518214#ent", "<e1>", ")", "of", "diabetic", "patients", "on", "oral", "C0020615#ent", "<e2>", "was", "compared", "to", "schizophrenic", "patients", "who", "were", "well", "controlled", "with", "their", "antipsychotic", "medications"], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [13, 14]}}
{"token": ["C1881122#ent", "<e1>", "also", "induced", "expression", "of", "the", "related", "cytokine", "C3890210#ent", "<e2>", "."], "h": {"id": "C1881122", "name": "C1881122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890210", "name": "C3890210#ent", "pos": [9, 10]}}
{"token": ["The", "phosphorylation", "of", "specific", "serine", "and", "threonine", "residues", "on", "C3538828#ent", "<e1>", "by", "several", "different", "C0010536#ent", "<e2>", "represents", "a", "major", "physiological", "mechanism", "for", "alteration", "of", "myofilament", "properties", "."], "h": {"id": "C3538828", "name": "C3538828#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [14, 15]}}
{"token": ["C1706586#ent", "<e1>", "kinase-dependent", "regulation", "of", "C1382029#ent", "<e2>", "dependent", "on", "the", "integrity", "of", "Ser750", "in", "the", "fourth", "intracellular", "loop", "of", "the", "enzyme", "and", "Ser603/Ser608", "in", "the", "C1b", "region", "of", "the", "molecule", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [5, 6]}}
{"token": ["Taken", "together", ",", "these", "studies", "link", "two", "signaling", "pathways", "previously", "characterized", "in", "human", "airway", "smooth", "muscle", "cells", "TNF-alpha", "transactivation", "of", "the", "EGF", "receptor", "with", "subsequent", "C1706586#ent", "<e1>", "kinase-mediated", "activation", "of", "C1382029#ent", "<e2>"], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [30, 31]}}
{"token": ["The", "compounds", "were", "potent", "inhibitors", "of", "dihydrofolate", "reductase", ",", "unlike", "C0025677#ent", "<e1>", ",", "they", "were", "also", "inhibitors", "of", "mammalian", "C1414689#ent", "<e2>"], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414689", "name": "C1414689#ent", "pos": [19, 20]}}
{"token": ["Instead", ",", "GM-CSF", "produced", "a", "rapid", "activation", "of", "C0812307#ent", "<e1>", "and", "Hck", ",", "but", "not", "C0919478#ent", "<e2>", ",", "tyrosine", "phosphorylation", "1", "min", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0919478", "name": "C0919478#ent", "pos": [15, 16]}}
{"token": ["Nef", "strongly", "activated", "Hck", ",", "C0812307#ent", "<e1>", ",", "and", "c-Src", "but", "did", "not", "detectably", "affect", "C0919478#ent", "<e2>", ",", "Fyn", ",", "Lck", ",", "or", "Yes", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919478", "name": "C0919478#ent", "pos": [15, 16]}}
{"token": ["A", "\"", "C1456687#ent", "<e1>", "\"", "syndrome", "characterized", "by", "new", "neuromuscular", "symptoms", "including", "C0151786#ent", "<e2>", "may", "develop", "years", "after", "recovery", "from", "acute", "paralytic", "poliomyelitis"], "h": {"id": "C1456687", "name": "C1456687#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0151786", "name": "C0151786#ent", "pos": [12, 13]}}
{"token": ["L-canavanine", "(", "LC", ")", "is", "an", "C2917660#ent", "<e1>", "in", "alfalfa", "seeds", "that", "provokes", "a", "disease", "state", "to", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e2>", ")", "in", "primates", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [20, 21]}}
{"token": ["C0015846#ent", "<e1>", "administration", "reversed", "diazepam-induced", "changes", "in", "C1427193#ent", "<e2>", "responses", "to", "the", "control", "level"], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427193", "name": "C1427193#ent", "pos": [7, 8]}}
{"token": ["Endothelial", "NOS", "eNOS", ")", "activity", "was", "not", "affected", "by", "C1414083#ent", "<e1>", "but", "inducible", "NOS", "(", "C1417760#ent", "<e2>", ")", "activity", "was", "seven-fold", "higher", "than", "control", "in", "the", "mdx", "mouse", "heart", "12", "months", "of", "age", "."], "h": {"id": "C1414083", "name": "C1414083#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [15, 16]}}
{"token": ["One", "patient", "was", "taking", "C0027396#ent", "<e1>", ",", "a", "weak", "C3826984#ent", "<e2>", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3826984", "name": "C3826984#ent", "pos": [9, 10]}}
{"token": ["The", "C1864669#ent", "<e1>", "NCL", ")", "are", "neurodegenerative", "disorders", "psychomotor", "deterioration", "C0036572#ent", "<e2>", ",", "visual", "failure", "premature", "death", "all", "associated", "with", "abnormal", "storage", "of", "lipoproteins", "within", "lysosomes", "."], "h": {"id": "C1864669", "name": "C1864669#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}}
{"token": ["In", "type", "II", "observed", "in", "10", "-", "15", "%", "of", "all", "patients", ",", "C0149676#ent", "<e1>", "in", "the", "entire", "body", "and", "C0010520#ent", "<e2>", "is", "associated", "with", "severe", ",", "progressive", "neurologic", "impairment"], "h": {"id": "C0149676", "name": "C0149676#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010520", "name": "C0010520#ent", "pos": [20, 21]}}
{"token": ["Cows", "'", "milk", "sensitive", "C0021831#ent", "<e1>", "is", "an", "important", "cause", "of", "failure", "to", "C2938208#ent", "<e2>", "in", "children", "with", "cystic", "fibrosis"], "h": {"id": "C0021831", "name": "C0021831#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2938208", "name": "C2938208#ent", "pos": [13, 14]}}
{"token": ["Experiments", "using", "C0282331#ent", "<e1>", "and", "indomethacin", "suggested", "that", "prostaglandin", "synthesis", "involved", "to", "mediate", "C1424250#ent", "<e2>", "effect", "at", "a", "step", "subsequent", "to", "cyclic", "AMP", "production", "."], "h": {"id": "C0282331", "name": "C0282331#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [13, 14]}}
{"token": ["We", "report", "here", "the", "determination", "of", "the", "nucleotide", "sequence", "the", "C1335232#ent", "<e1>", "encoding", "the", "D.", "africanus", "C4078840#ent", "<e2>", "."], "h": {"id": "C1335232", "name": "C1335232#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4078840", "name": "C4078840#ent", "pos": [16, 17]}}
{"token": ["Western", "blot", "analysis", "these", "nuclear", "extracts", "the", "presence", "of", "C1367307#ent", "<e1>", "and", "STAT5", ",", "suggesting", "that", "these", "STATs", "can", "induce", "C1414549#ent", "<e2>", "in", "this", "situation", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414549", "name": "C1414549#ent", "pos": [20, 21]}}
{"token": ["C1412332#ent", "<e1>", "was", "the", "main", "carrier", "of", "CPT-11", "and", "C0142710#ent", "<e2>", "in", "plasma", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0142710", "name": "C0142710#ent", "pos": [9, 10]}}
{"token": ["The", "permeability", "to", "the", "lipophilic", "solutes", "methanol", ",", "ethanol", "and", "C0003420#ent", "<e1>", "was", "not", "affected", "by", "any", "of", "these", "C0991617#ent", "<e2>", "."], "h": {"id": "C0003420", "name": "C0003420#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [19, 20]}}
{"token": ["Dogs", "were", "C0342895#ent", "<e1>", "a", "continuous", "diet", "phenylalanine", "(", "Phe", ")", "daily", "and", "C0030135#ent", "<e2>", "(", "p-CPhe", ")", ",", "an", "inhibitor", "of", "phenylalanine", "hydroxylase", "PH-ase", ")", "every", "second", "day", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [13, 14]}}
{"token": ["The", "treatment", "of", "cotyledons", "by", "heat-denatured", "cellulase", "also", "led", "to", "some", "induction", "of", "peroxidase", "and", "C0008145#ent", "<e1>", "activities", ",", "but", "the", "oxidative", "burst", "C1825840#ent", "<e2>", "production", "were", "not", "observed", "."], "h": {"id": "C0008145", "name": "C0008145#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [23, 24]}}
{"token": ["The", "in", "vivo", "binding", "kinetics", "of", "C1413107#ent", "<e1>", "and", "calreticulin", "to", "C1414406#ent", "<e2>", "were", "very", "similar", "."], "h": {"id": "C1413107", "name": "C1413107#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414406", "name": "C1414406#ent", "pos": [11, 12]}}
{"token": ["Pruritus", "was", "more", "common", "in", "the", "fentanyl", "group", "and", "leg", "heaviness", "in", "the", "C0360097#ent", "<e1>", "group", ",", "but", "neither", "was", "C3642475#ent", "<e2>", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3642475", "name": "C3642475#ent", "pos": [20, 21]}}
{"token": ["Twenty", "MD", "patients", "(", "4", "with", "dystrophinopathy", ",", "5", "with", "C0410226#ent", "<e1>", "5", "with", "fascioscapulohumeral", "MD", "and", "6", "with", "C0686353#ent", "<e2>", "and", "10", "healthy", "subjects", "in", "the", "study", "."], "h": {"id": "C0410226", "name": "C0410226#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [19, 20]}}
{"token": ["Notably", ",", "a", "glutamic", "acid", "residue", "position", "2", "of", "C1364818#ent", "<e1>", "is", "in", "C1417772#ent", "<e2>", "replaced", "by", "proline", ",", "which", "shortens", "one", "of", "the", "two", "amphipathic", "alpha-helices", "considered", "crucial", "for", "the", "pore-forming", "function", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417772", "name": "C1417772#ent", "pos": [13, 14]}}
{"token": ["The", "secretion", "rate", "of", "C1706574#ent", "<e1>", "from", "SCLC", "cells", "is", "increased", "by", "C1366646#ent", "<e2>", "VIP", ")", ",", "which", "elevates", "the", "intracellular", "cAMP", "."], "h": {"id": "C1706574", "name": "C1706574#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366646", "name": "C1366646#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "appeared", "to", "be", "mediated", "by", "PKC", "since", "C0012262#ent", "<e1>", "caused", "the", "same", "amplification", "as", "did", "C0032143#ent", "<e2>", "while", "inactive", "phorbol", "esters", "without", "effect", "."], "h": {"id": "C0012262", "name": "C0012262#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "the", "dose-response", "curves", "for", "fentanyl", "and", "sufentanil", "were", "shifted", "to", "the", "left", "and", "the", "ED50", "of", "the", "C0728960#ent", "<e1>", "lowered", "in", "C0013136#ent", "<e2>", "pre-treated", "animals", "."], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0013136", "name": "C0013136#ent", "pos": [23, 24]}}
{"token": ["Indeed", ",", "inhibition", "of", "ROCKs", "by", "statins", "or", "other", "selective", "inhibitors", "leads", "to", "the", "upregulation", "and", "activation", "of", "C0907532#ent", "<e1>", "eNOS", ")", "and", "reduction", "of", "vascular", "inflammation", "C0003850#ent", "<e2>", "."], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [27, 28]}}
{"token": ["Emergence", "of", "resistance", "to", "multiple", "antibiotics", ",", "including", "C0008809#ent", "<e1>", ",", "during", "the", "treatment", "of", "C0029443#ent", "<e2>", "SCD", "patients", "is", "reported", "here", "for", "the", "first", "time", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [15, 16]}}
{"token": ["Tumor", "necrosis", "factor", "alpha", "and", "in", "the", "presence", "of", "LH", "and/or", "prostaglandin", "F2alpha", "elevated", "steady-state", "amounts", "of", "C1419011#ent", "<e1>", "mRNA", "but", "did", "not", "affect", "C1419018#ent", "<e2>", "mRNA", "in", "cultured", "luteal", "cells"], "h": {"id": "C1419011", "name": "C1419011#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419018", "name": "C1419018#ent", "pos": [24, 25]}}
{"token": ["On", "each", "treatment", "day", ",", "significantly", "fewer", "patients", "receiving", "C0004147#ent", "<e1>", "required", "concomitant", "C0005064#ent", "<e2>", ",", "and", "patients", "receiving", "placebo", "required", "a", "significantly", "higher", "mean", "daily", "dose", "of", "C0005064#ent", "<e2>", "."], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [13, 14]}}
{"token": ["The", "natural", "abundance", "spectra", "of", "five", "alpha-adrenergic", "blocking", "agents", "tolazoline", ",", "dibenamine", ",", "C0004477#ent", "<e1>", ",", "phenoxybenzamine", ",", "and", "C0031448#ent", "<e2>", ",", "are", "reported", "."], "h": {"id": "C0004477", "name": "C0004477#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [19, 20]}}
{"token": ["These", "results", ",", "together", "with", "previous", "findings", "showing", "that", "tyrosine", "phosphorylation", "C0136864#ent", "<e1>", "its", "catalytic", "activity", "indicate", "that", "phosphorylation", "of", "C0136864#ent", "<e1>", "a", "C1540033#ent", "<e1>", "the", "mechanism", "by", "which", "IgE", "receptor", "aggregation", "triggers", "PLC", "activation", "."], "h": {"id": "C0136864", "name": "C0136864#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1540033", "name": "C1540033#ent", "pos": [23, 24]}}
{"token": ["To", "compare", "the", "radiographic", "outcomes", "after", "36", "months", "in", "patients", "with", "early", "erosive", "rheumatoid", "arthritis", "C0003873#ent", "<e1>", ")", "who", "were", "treated", "with", "methotrexate", "(", "MTX", ")", "or", "C0018034#ent", "<e2>", "GSTM", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0018034", "name": "C0018034#ent", "pos": [27, 28]}}
{"token": ["The", "most", "expressed", "degree", "of", "cellular", "and", "C0221026#ent", "<e1>", "caused", "by", "C0038166#ent", "<e2>"], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038166", "name": "C0038166#ent", "pos": [11, 12]}}
{"token": ["All", "patients", "had", "biopsy-proven", "primary", "FSGS", "had", "no", "family", "history", "C0012634#ent", "<e1>", "consanguinity", ",", "were", "C0403397#ent", "<e2>", ",", "and", "received", "living-related", "renal", "transplantation", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0403397", "name": "C0403397#ent", "pos": [15, 16]}}
{"token": ["GLA", "is", "further", "metabolized", "to", "dihomogamma", "linlenic", "acid", "DGLA", ")", "which", "undergoes", "oxidative", "metabolism", "cyclooxygenases", "and", "C0023837#ent", "<e1>", "to", "produce", "anti-inflammatory", "eicosanoids", "C3540754#ent", "<e2>", "of", "series", "1", "and", "leukotrienes", "of", "series", "3", ")", "."], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [22, 23]}}
{"token": ["Hydroxyeicosatetraenoic", "acid", "methyl", "esters", "HETEs", ")", "are", "C0023837#ent", "<e1>", "arachidonic", "acid", "are", "generated", "along", "with", "C3540754#ent", "<e2>", "(", "PGs", ")", "during", "acute", "inflammatory", "reactions"], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "C0053941#ent", "<e1>", ",", "a", "new", "nonselective", "C0304516#ent", "<e2>", "on", "platelet", "function", "been", "studied", "in", "10", "male", "hypertensive", "patients", "given", "the", "drug", "(", "1", "mg/day", ")", "in", "turn", "for", "eight", "weeks", "."], "h": {"id": "C0053941", "name": "C0053941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [9, 10]}}
{"token": ["Circulatory", "effects", "C0053941#ent", "<e1>", ",", "a", "new", "C0304516#ent", "<e2>", "intrinsic", "sympathomimetic", "activity", "atenolol", "were", "compared", "."], "h": {"id": "C0053941", "name": "C0053941#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [7, 8]}}
{"token": ["Currently", ",", "the", "two", "most", "frequently", "used", "C0003374#ent", "<e1>", "chloroquine", "and", "C0596007#ent", "<e2>", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0596007", "name": "C0596007#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "PFDA", "and", "CPIB", "compete", "with", "long-chain", "fatty", "acids", "binding", "to", "C1707996#ent", "<e1>", "but", "do", "not", "compete", "with", "long-chain", "acyl-CoA", "esters", "binding", "to", "C1413917#ent", "<e2>", "."], "h": {"id": "C1707996", "name": "C1707996#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413917", "name": "C1413917#ent", "pos": [25, 26]}}
{"token": ["These", "studies", "show", "that", "C0040233#ent", "<e1>", "is", "a", "potent", ",", "long", "acting", "C1367657#ent", "<e2>", "blocking", "drug", "without", "evidence", "of", "alpha-adrenoceptor", "blockade", "in", "man", "."], "h": {"id": "C0040233", "name": "C0040233#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [12, 13]}}
{"token": ["The", "cardiovascular", "effects", "of", "C0040233#ent", "<e1>", ",", "a", "new", ",", "potent", ",", "long", "acting", "C1367657#ent", "<e2>", "blocking", "drug", "were", "investigated", "in", "three", "studies", "."], "h": {"id": "C0040233", "name": "C0040233#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [14, 15]}}
{"token": ["Nonfunctioning", "adrenal", "adenomas", "expressed", "all", "mRNAs", "of", "P450scc", ",", "C1706114#ent", "<e1>", ",", "P450c21", ",", "adrenodoxin", ",", "and", "C0015857#ent", "<e2>", "relative", "levels", "comparable", "to", "those", "found", "in", "normal", "adrenals", "."], "h": {"id": "C1706114", "name": "C1706114#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015857", "name": "C0015857#ent", "pos": [17, 18]}}
{"token": ["Anti-TNF", "agents", "are", "of", "particular", "relevance", "to", "AS", "patients", "with", "concomitant", "C0022104#ent", "<e1>", "who", "are", "at", "risk", "of", "exacerbation", "of", "the", "underlying", "C0341268#ent", "<e2>", "treated", "with", "NSAIDs", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0341268", "name": "C0341268#ent", "pos": [22, 23]}}
{"token": ["To", "examine", "the", "involvement", "of", "p38", "mitogen-activated", "protein", "kinase", "MAPK", ")", "in", "C0004364#ent", "<e1>", "the", "peripheral", "nerve", "system", "we", "analyzed", "the", "phosphorylation", "of", "C1120843#ent", "<e2>", "the", "sciatic", "nerves", "Lewis", "rats", "experimental", "autoimmune", "neuritis", "EAN", ")", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [23, 24]}}
{"token": ["To", "understand", "the", "molecular", "mechanisms", "cellular", "signaling", "atrial", "natriuretic", "peptide", "ANP", ")", ",", "we", "have", "studied", "its", "effect", "on", "the", "enzymatic", "activity", "endogenous", "and", "overexpressed", "C0033634#ent", "<e1>", "PKC", ")", "in", "rat", "C1412137#ent", "<e2>", "RTASM", ")", "cells", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [31, 32]}}
{"token": ["Chronic", "kidney", "disease", "C2974542#ent", "<e1>", ")", "is", "associated", "with", "increase", "in", "inflammatory", "cytokines", "can", "result", "in", "C1516009#ent", "<e2>", "with", "loss", "of", "muscle", "fat", "stores", "."], "h": {"id": "C2974542", "name": "C2974542#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516009", "name": "C1516009#ent", "pos": [16, 17]}}
{"token": ["L-Tryptophan", "degradation", "by", "C0041256#ent", "<e1>", "IDO", ")", "induction", "and", "reactive", "nitrogen", "intermediates", "produced", "by", "C1533698#ent", "<e2>", "iNOS", ")", "induction", "are", "important", "factors", "for", "IFN-gamma-induced", "anti-toxoplasma", "activities", "."], "h": {"id": "C0041256", "name": "C0041256#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [14, 15]}}
{"token": ["Hereditary", "coproporphyria", "HC", ")", "is", "an", "C0268328#ent", "<e1>", "autosomal", "dominant", "inheritance", "caused", "by", "a", "deficient", "activity", "of", "C0072500#ent", "<e2>", "CPX", ")", "."], "h": {"id": "C0268328", "name": "C0268328#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072500", "name": "C0072500#ent", "pos": [17, 18]}}
{"token": ["The", "presence", "of", "parental", "consanguinity", "and", "absence", "of", "affected", "individuals", "in", "succeeding", "or", "preceding", "generations", "suggested", "that", "the", "C1112256#ent", "<e1>", "this", "family", "is", "inherited", "in", "an", "C3899988#ent", "<e2>", "."], "h": {"id": "C1112256", "name": "C1112256#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [26, 27]}}
{"token": ["C0025872#ent", "<e1>", "has", "notable", "effectiveness", "in", "treating", "anaerobic", "C0006105#ent", "<e2>"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006105", "name": "C0006105#ent", "pos": [8, 9]}}
{"token": ["An", "ex", "vivo", "binding", "analysis", "isotope-labeled", "antibodies", "and", "lung", "sections", "taken", "at", "various", "times", "up", "to", "48", "hours", "after", "C0017696#ent", "<e1>", "infusion", "revealed", "a", "progressive", "increase", "in", "whole-lung", "C1706544#ent", "<e2>", "expression", "."], "h": {"id": "C0017696", "name": "C0017696#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [28, 29]}}
{"token": ["C1313497#ent", "<e1>", "can", "be", "detected", "in", "crude", "extracts", "both", "functional", "activity", "the", "C0034361#ent", "<e2>", "by", "immunodiffusion", "with", "antibody", "made", "against", "E.", "coli", "HF"], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034361", "name": "C0034361#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "we", "synthesized", "amide", "derivatives", "four", "well-known", "NSAIDs", ",", "i.e.", "C0012091#ent", "<e1>", "tolfenamic", "acid", "ibuprofen", "and", "indomethacin", ",", "with", "C0010648#ent", "<e2>", ",", "a", "well-known", "antioxidant", "."], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010648", "name": "C0010648#ent", "pos": [20, 21]}}
{"token": ["The", "composition", "of", "the", "two", "C0815040#ent", "<e1>", "in", "Zuguangsan", ",", "a", "traditional", "C0013231#ent", "<e2>", "was", "determined", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013231", "name": "C0013231#ent", "pos": [12, 13]}}
{"token": ["The", "presence", "of", "C3273424#ent", "<e1>", "in", "a", "variety", "of", "cell", "types", "that", "the", "function", "of", "C3273424#ent", "<e1>", "is", "not", "restricted", "to", "adrenal", "cells", "to", "specific", "actions", "of", "C1704793#ent", "<e1>", "."], "h": {"id": "C3273424", "name": "C3273424#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [27, 28]}}
{"token": ["We", "tested", "whether", "increased", "endogenous", "adenosine", "produced", "by", "the", "C2746041#ent", "<e1>", "GP-515", "(", "Metabasis", "Therapeutics", ")", "can", "induce", "vascular", "endothelial", "growth", "factor", "C1522575#ent", "<e2>", ")", "expression", "in", "cultured", "rat", "myocardial", "myoblasts", "RMMs", ")", "."], "h": {"id": "C2746041", "name": "C2746041#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [22, 23]}}
{"token": ["Two", "case-reports", "of", "C0040034#ent", "<e1>", "induced", "by", "C0524684#ent", "<e2>", "PSP", ")", "are", "reported", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524684", "name": "C0524684#ent", "pos": [7, 8]}}
{"token": ["This", "is", "compounded", "by", "C0268487#ent", "<e1>", "in", "the", "medical", "management", "C0917805#ent", "<e2>", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0917805", "name": "C0917805#ent", "pos": [10, 11]}}
{"token": ["All", "patients", "with", "C0006035#ent", "<e1>", "IgG", "antibodies", "against", "the", "C1540205#ent", "<e2>", "."], "h": {"id": "C0006035", "name": "C0006035#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1540205", "name": "C1540205#ent", "pos": [9, 10]}}
{"token": ["We", "report", "a", "46-year-old", "man", "with", "C0221043#ent", "<e1>", "hypokalemia", ",", "periodic", "paralysis", "hypokalemic", "myopathy", "clinical", "course", "with", "the", "dosage", "of", "C0088341#ent", "<e2>", "a", "dihydropyridine", "calcium", "channel", "blocker", "DHP-CCB", ")", ",", "administered", "for", "the", "treatment", "of", "hypertension", "."], "h": {"id": "C0221043", "name": "C0221043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0088341", "name": "C0088341#ent", "pos": [20, 21]}}
{"token": ["In", "this", "group", "26", "had", "isolated", "serum", "C1364508#ent", "<e1>", "Ab", "elevation", ",", "18", "had", "Hashimoto's", "disease", "1", "C0018213#ent", "<e2>"], "h": {"id": "C1364508", "name": "C1364508#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0018213", "name": "C0018213#ent", "pos": [17, 18]}}
{"token": ["Among", "diseases", "with", "abdominal", "calcifications", "calcification", "of", "lymph", "nodes", "found", "most", "frequently", "and", "in", "0.24", "%", ",", "followed", "by", "C0856727#ent", "<e1>", "in", "0.085", "%", "and", "C0451641#ent", "<e2>", "in", "0.004", "%", "."], "h": {"id": "C0856727", "name": "C0856727#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [25, 26]}}
{"token": ["Subjects", "were", "25", "C0011854#ent", "<e1>", "patients", "with", "AITD", "(", "13", "Graves'", "disease", "12", "C0342124#ent", "<e2>", "and", "32", "C0011854#ent", "<e1>", "patients", "without", "AITD", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0342124", "name": "C0342124#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "report", "the", "case", "of", "a", "27-year-old", "man", "who", "presented", "with", "C0011854#ent", "<e1>", "subsequently", "developed", "C0342124#ent", "<e2>", "hypogonadism", ",", "and", "primary", "biliary", "cirrhosis"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0342124", "name": "C0342124#ent", "pos": [16, 17]}}
{"token": ["Further", ",", "unlike", "in", "budding", "yeast", "rad18", "is", "not", "epistatic", "to", "C1826797#ent", "<e1>", "for", "DNA", "damage", "suggesting", "that", "REV1", "and", "C1425416#ent", "<e2>", "play", "largely", "independent", "roles", "in", "the", "control", "of", "vertebrate", "translesion", "synthesis", "."], "h": {"id": "C1826797", "name": "C1826797#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1425416", "name": "C1425416#ent", "pos": [20, 21]}}
{"token": ["In", "eight", "unrelated", "cases", "of", "McArdle's", "disease", "which", "no", "inactive", "C0086376#ent", "<e1>", "had", "been", "detected", ",", "we", "assayed", "muscle", "biopsies", "C0917783#ent", "<e2>", "mRNA", "by", "Northern", "blotting"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0917783", "name": "C0917783#ent", "pos": [20, 21]}}
{"token": ["Conversion", "of", "nine", "separate", "lysines", "to", "glutamic", "acid", "in", "C0086376#ent", "<e1>", "that", "were", "still", "capable", "of", "C0917783#ent", "<e2>", "acceptance", "from", "HPr", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0917783", "name": "C0917783#ent", "pos": [16, 17]}}
{"token": ["Opsonization", "of", "apoptotic", "cardiocytes", "by", "maternal", "C1540056#ent", "<e1>", "and", "anti-La/SSB", "antibodies", "contributes", "to", "tissue", "injury", "the", "neonatal", "C0024141#ent", "<e2>"], "h": {"id": "C1540056", "name": "C1540056#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [17, 18]}}
{"token": ["C0019189#ent", "<e1>", "the", "risk", "to", "develop", "C0543697#ent", "<e2>", "MC", ")", "and", "B-cell", "non-Hodgkin's", "lymphoma", "B-NHL", ")", ",", "possibly", "because", "viral", "antigens", "stimulate", "the", "host", "'s", "inflammatory", "response", "extracellular", "pattern", "recognition", "receptors", "PRR", ")", "."], "h": {"id": "C0019189", "name": "C0019189#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0543697", "name": "C0543697#ent", "pos": [6, 7]}}
{"token": ["The", "relative", "risk", "C0011849#ent", "<e1>", "among", "patients", "undergoing", "C0073393#ent", "<e2>", "treatment", "was", "compared", "with", "that", "of", "patients", "receiving", "olanzapine", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073393", "name": "C0073393#ent", "pos": [8, 9]}}
{"token": ["Effectiveness", "of", "C1418754#ent", "<e1>", "was", "evaluated", "by", "a", "decrease", "in", "spleen", "size", "C0020532#ent", "<e2>", ",", "disappearance", "of", "esophageal", "varices", "improvement", "in", "blood", "count"], "h": {"id": "C1418754", "name": "C1418754#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020532", "name": "C0020532#ent", "pos": [12, 13]}}
{"token": ["This", "review", "summarizes", "recent", "literature", "on", "the", "role", "of", "primary", "cilia", "intracellular", "calcium", "homeostasis", "and", "signaling", "involving", "Wnt", ",", "cyclic", "AMP", "C3537369#ent", "<e1>", ",", "in", "the", "pathogenesis", "of", "C3149841#ent", "<e2>"], "h": {"id": "C3537369", "name": "C3537369#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [28, 29]}}
{"token": ["The", "finding", "of", "transition", "mutations", "exclusively", "at", "GG", "sites", "may", "be", "of", "predictive", "value", "attempts", "to", "link", "dietary", "aflatoxin", "exposure", "to", "cancers", "associated", "with", "mutations", "in", "the", "C0139905#ent", "<e1>", "oncogene", "and", "the", "C0079419#ent", "<e2>"], "h": {"id": "C0139905", "name": "C0139905#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0079419", "name": "C0079419#ent", "pos": [32, 33]}}
{"token": ["The", "\"", "vacuolar", "variant", "of", "C0410180#ent", "<e1>", "causes", "mild", ",", "generalized", ",", "and", "slowly", "progressive", "C0427055#ent", "<e2>", "."], "h": {"id": "C0410180", "name": "C0410180#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [15, 16]}}
{"token": ["These", "findings", "of", "decreased", "C0339510#ent", "<e1>", "rate", "in", "the", "bones", "of", "gad", "mice", "suggest", "that", "C1421309#ent", "<e2>", "function", "regulates", "bone", "mineralization", "osteogenesis", "."], "h": {"id": "C0339510", "name": "C0339510#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421309", "name": "C1421309#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "the", "role", "of", "C0524891#ent", "<e1>", "a", "model", "of", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", ",", "we", "studied", "Theiler", "'s", "virus", "infection", "in", "congenic", "mice", "deletion", "of", "TCR", "V", "beta", "chromosome", "."], "h": {"id": "C0524891", "name": "C0524891#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [12, 13]}}
{"token": ["We", "have", "investigated", "the", "effects", "of", "plasma", "HIV", "RNA", "C0206744#ent", "<e1>", "chemokine", "receptors", "CCR5", "and", "CCR2b", "on", "C0343755#ent", "<e2>", "progression", "in", "hemophiliacs", "."], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0343755", "name": "C0343755#ent", "pos": [17, 18]}}
{"token": ["The", "C0007841#ent", "<e1>", "MCOs", ")", "couple", "the", "four-electron", "reduction", "of", "C0599874#ent", "<e2>", "to", "water", "with", "four", "one-electron", "oxidations", "of", "various", "substrates", "."], "h": {"id": "C0007841", "name": "C0007841#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599874", "name": "C0599874#ent", "pos": [10, 11]}}
{"token": ["The", "N-terminal", "amino", "acid", "sequence", "some", "of", "the", "antigens", "was", "C1512488#ent", "<e1>", "with", "casein", ",", "gliadin", ",", "fibrinogen", ",", "and", "C0009325#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [20, 21]}}
{"token": ["Further", ",", "since", "the", "sites", "of", "C0064305#ent", "<e1>", "the", "RNA", "sequences", "intact", "C0599220#ent", "<e2>", "are", "known", ",", "the", "task", "of", "identifying", "the", "components", "of", "individual", "ribonucleoprotein", "complexes", "be", "considerably", "simplified", "."], "h": {"id": "C0064305", "name": "C0064305#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}}
{"token": ["The", "deletion", "spectrum", "het-6", "thus", "resembles", "other", "cases", "where", "mitotic", "deletions", "occur", "such", "as", "of", "tumor", "suppressor", "genes", "of", "the", "C1415701#ent", "<e1>", "coding", "for", "C0020687#ent", "<e2>", "in", "humans", "."], "h": {"id": "C1415701", "name": "C1415701#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0020687", "name": "C0020687#ent", "pos": [24, 25]}}
{"token": ["Incubation", "of", "C1709384#ent", "<e1>", "with", "purified", "C1418898#ent", "<e2>", "resulted", "in", "the", "phosphorylation", "of", "C1709384#ent", "<e1>", ";", "and", "the", "inclusion", "of", "AMP", "as", "an", "AMPK", "activator", "potentiated", "C1709384#ent", "<e1>", "phosphorylation", "."], "h": {"id": "C1709384", "name": "C1709384#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418898", "name": "C1418898#ent", "pos": [6, 7]}}
{"token": ["The", "molecules", "discussed", "include", "Src", "family", "kinases", "Syk", ",", "Grb2", "adaptor", "protein", "and", "C0031727#ent", "<e1>", "Bmx", "and", "C1528376#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528376", "name": "C1528376#ent", "pos": [17, 18]}}
{"token": ["Taken", "together", ",", "it", "seems", "that", "EMT", "is", "a", "member", "of", "a", "new", "family", "of", "intracellular", "C0031727#ent", "<e1>", "that", "includes", "C1528376#ent", "<e2>", ",", "TECI", ",", "and", "TECII", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [16, 17]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528376", "name": "C1528376#ent", "pos": [20, 21]}}
{"token": ["C0029310#ent", "<e1>", "may", "also", "possess", "analgesic", "properties", "in", "conditions", "not", "involving", "C0037763#ent", "<e2>"], "h": {"id": "C0029310", "name": "C0029310#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0037763", "name": "C0037763#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "examined", "T(reg", ")", "cell", "development", "function", "in", "mice", "with", "a", "C1416467#ent", "<e1>", "allele", "that", "directs", "expression", "of", "a", "nonfunctional", "fusion", "protein", "of", "C1416467#ent", "<e1>", "and", "enhanced", "green", "fluorescent", "protein", "C3539868#ent", "<e1>", ")", "."], "h": {"id": "C1416467", "name": "C1416467#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539868", "name": "C3539868#ent", "pos": [31, 32]}}
{"token": ["The", "sequence", "of", "cDNAs", "encoding", "C3538775#ent", "<e1>", "indicate", "that", "it", "is", "a", "C3539619#ent", "<e2>", "a", "predicted", "molecular", "weight", "81,880", "and", "an", "unusually", "acidic", "lumenal", "domain", "."], "h": {"id": "C3538775", "name": "C3538775#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539619", "name": "C3539619#ent", "pos": [12, 13]}}
{"token": ["We", "report", "an", "analysis", "of", "the", "sequences", "used", "in", "the", "excision", "of", "the", "C1819716#ent", "<e1>", "22", "spontaneous", "and", "ten", "C0015008#ent", "<e2>", "Saccharomyces", "cerevisiae", "petite", "mutants", "."], "h": {"id": "C1819716", "name": "C1819716#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015008", "name": "C0015008#ent", "pos": [19, 20]}}
{"token": ["As", "increasingly", "indicated", "in", "the", "literature", ",", "C0151864#ent", "<e1>", "such", "as", "preeclampsia", "and", "C0085207#ent", "<e2>", "represent", "potential", "targets", "for", "treatment", "with", "PPAR", "ligands"], "h": {"id": "C0151864", "name": "C0151864#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [13, 14]}}
{"token": ["An", "open-label", ",", "randomized", "controlled", "study", "conducted", "at", "a", "tertiary", "care", "teaching", "hospital", "compare", "efficacy", "and", "safety", "of", "intravenous", "sodium", "valproate", "C0012010#ent", "<e1>", "infusion", "for", "control", "of", "C0038220#ent", "<e2>"], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [27, 28]}}
{"token": ["The", "enzyme", "inhibition", "was", "analyzed", "in", "vitro", "measuring", "the", "5", "C0055533#ent", "<e1>", "in", "the", "presence", "of", "either", "C2757070#ent", "<e2>", ",", "estrone", ",", "or", "estradiol", ",", "using", "testosterone", "as", "substrate", "."], "h": {"id": "C0055533", "name": "C0055533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [17, 18]}}
{"token": ["The", "pituitary", "5", "alpha-reductase", "activity", "not", "blocked", "at", "1500", "h.", "However", ",", "both", "pituitary", "and", "C0055533#ent", "<e1>", "blocked", "at", "the", "time", "of", "C2757070#ent", "<e2>", "administration", "."], "h": {"id": "C0055533", "name": "C0055533#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [22, 23]}}
{"token": ["Propylisopropylacetamide", "(", "PID", ")", "is", "a", "chiral", "CNS-active", "constitutional", "isomer", "C0058426#ent", "<e1>", ",", "the", "amide", "derivative", "the", "major", "C0003299#ent", "<e2>", "valproic", "acid", "VPA", ")", "."], "h": {"id": "C0058426", "name": "C0058426#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [18, 19]}}
{"token": ["These", "data", "indicate", "that", "none", "of", "the", "C0599220#ent", "<e1>", "soluble", "extracts", "of", "preovulatory", "follicle-enriched", "ovaries", "exhibit", "intrinsic", "C0012920#ent", "<e2>", "activity", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012920", "name": "C0012920#ent", "pos": [17, 18]}}
{"token": ["The", "C0035086#ent", "<e1>", "a", "mild", "glomerulonephritis", "mesangial", "and", "subendothelial", "immune", "deposits", "IgG", ",", "C1706005#ent", "<e2>", "and", "C3", ",", "increased", "mesangial", "matrix", "significant", "cell", "proliferation"], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "suggest", "a", "possible", "therapeutic", "role", "for", "C0338271#ent", "<e1>", "2123/parnaparin", "in", "both", "diabetic", "neuropathy", "microangiopathy", ",", "frequent", "complications", "of", "C0011849#ent", "<e2>", "."], "h": {"id": "C0338271", "name": "C0338271#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [20, 21]}}
{"token": ["HPMC", "PAI-1", "is", "increased", "by", "transforming", "growth", "factor-beta", "TGF-beta", ")", "and", "tumor", "necrosis", "factor-alpha", "C1710304#ent", "<e1>", ")", ",", "as", "is", "C0032143#ent", "<e2>", "release", ",", "while", "PAI-1", "mRNA", "is", "unchanged", "and", "C0032143#ent", "<e2>", "mRNA", "is", "increased", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [20, 21]}}
{"token": ["This", "fasting", "C0020616#ent", "<e1>", "was", "completely", "reversed", "by", "giving", "oral", "medium-chain", "fatty", "acids", "C0724624#ent", "<e2>", ")", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [13, 14]}}
{"token": ["In", "practice", ",", "three", "main", "categories", "of", "C0018681#ent", "<e1>", "can", "be", "indicative", "of", "C0442893#ent", "<e2>", "craniofacial", "pain", "migraine", "and", "pseudo-migraine", ";", "and", "C0018681#ent", "<e1>", "caused", "by", "intracranial", "hypertension"], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [7, 8]}}
{"token": ["Despite", "the", "decline", "of", "C0041327#ent", "<e1>", "the", "Western", "world", "the", "incidence", "of", "C0026918#ent", "<e2>", "remained", "relatively", "unaffected", "."], "h": {"id": "C0041327", "name": "C0041327#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [12, 13]}}
{"token": ["HTLV-1", "C0275524#ent", "<e1>", "may", "adversely", "effect", "the", "clinical", "course", "C0036262#ent", "<e2>", "and", "HIV", "disease"], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036262", "name": "C0036262#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "the", "Grey", "Verhulst", "model", "is", "used", "to", "fit", "the", "C0024530#ent", "<e1>", "incidence", "for", "the", "study", "of", "the", "declining", "tendency", "of", "C0024537#ent", "<e2>", "C0024530#ent", "<e1>", "incidence", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024537", "name": "C0024537#ent", "pos": [22, 23]}}
{"token": ["There", "were", "40", "cases", "of", "P", "falciparum", "C0024530#ent", "<e1>", ",", "14", "cases", "of", "C0024537#ent", "<e2>", "C0024530#ent", "<e1>", "and", "21", "cases", "of", "non-malarial", "fevers", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024537", "name": "C0024537#ent", "pos": [13, 14]}}
{"token": ["C0031448#ent", "<e1>", "blocked", "while", "propranolol", ",", "haloperidol", ",", "and", "C0031935#ent", "<e2>", "did", "not", "influence", "the", "DA", "effect", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [9, 10]}}
{"token": ["In", "the", "low", "passage", "line", "8", "of", "the", "compounds", "(", "colchicine", ",", "C0042671#ent", "<e1>", ",", "chloral", "hydrate", "thiabendazole", ",", "thimerosal", ",", "C0086620#ent", "<e2>", "pyrimethamine", "and", "diazepam", ")", "induced", "aneuploidy", "and/or", "tetraploidy", "."], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086620", "name": "C0086620#ent", "pos": [21, 22]}}
{"token": ["The", "altered", "C1334096#ent", "<e1>", "gene", "expression", "granule", "cell", "may", "modulate", "the", "interaction", "of", "C1334089#ent", "<e2>", "with", "IGFR-I", "in", "ways", "that", "contribute", "to", "their", "massive", "death", "occurring", "in", "the", "development", "of", "wv/wv", "cerebellum", "."], "h": {"id": "C1334096", "name": "C1334096#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [13, 14]}}
{"token": ["The", "molecularly", "imprinted", "polymer", "(", "C1417170#ent", "<e1>", ")", "was", "prepared", "by", "non-covalent", "molecular", "imprinting", "either", "(-)-", "or", "C0031495#ent", "<e2>", "as", "the", "template", "."], "h": {"id": "C1417170", "name": "C1417170#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031495", "name": "C0031495#ent", "pos": [17, 18]}}
{"token": ["In", "the", "case", "of", "propranolol", ",", "doxapram", ",", "C1161352#ent", "<e1>", ",", "dipyridamole", "and", "C0080356#ent", "<e2>", ",", "no", "or", "little", "protection", "were", "observed", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0080356", "name": "C0080356#ent", "pos": [13, 14]}}
{"token": ["There", "was", "no", "discernible", "difference", "in", "the", "pattern", "of", "C0000737#ent", "<e1>", "DU", ",", "GU", ",", "and", "C1416920#ent", "<e2>", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416920", "name": "C1416920#ent", "pos": [16, 17]}}
{"token": ["For", "example", ",", "C3273437#ent", "<e1>", "increases", "the", "expression", "of", "the", "C1420639#ent", "<e2>", "and", "increases", "abundance", "and", "phosphorylation", "of", "c-Jun", "protein"], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420639", "name": "C1420639#ent", "pos": [10, 11]}}
{"token": ["Comparison", "of", "the", "dose-dependent", "effects", "of", "C0076678#ent", "<e1>", "on", "ICa", "and", "C1416611#ent", "<e2>", "suggested", "that", "C0076678#ent", "<e1>", "may", "selectively", "inhibit", "catecholamine-induced", "increase", "of", "C1416611#ent", "<e2>", "at", "the", "therapeutic", "concentrations"], "h": {"id": "C0076678", "name": "C0076678#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416611", "name": "C1416611#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "C2757070#ent", "<e1>", ",", "but", "not", "C0280858#ent", "<e2>", ",", "can", "be", "used", "to", "differentiate", "the", "two", "mdr", "gene", "products", "in", "the", "mouse", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [9, 10]}}
{"token": ["Phosphatidylinositol", "appeared", "to", "be", "broken", "down", "by", "a", "C0031672#ent", "<e1>", "D.", "All", "the", "C3540017#ent", "<e2>", "examined", "were", "particulate", ";", "similar", "activities", "were", "found", "in", "Saccharomyces", "cerevisiae"], "h": {"id": "C0031672", "name": "C0031672#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [13, 14]}}
{"token": ["Another", "10", "patients", "with", "C0025297#ent", "<e1>", "associated", "with", "Coxsackie", "A9", "virus", "infection", "investigated", "and", "three", "patients", "had", "significant", "C0010246#ent", "<e2>", "their", "cerebrospinal", "fluids", "14", "-", "20", "days", "after", "onset", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010246", "name": "C0010246#ent", "pos": [18, 19]}}
{"token": ["Cell", "contact", "FN", "in", "contrast", "to", "C0142915#ent", "<e1>", "elevated", "basal", "C0385469#ent", "<e2>", ",", "PKBalpha/Akt", "and", "GSK-3beta", "kinase", "activities", "in", "A549", "and", "CCD32", "cells", ",", "as", "well", "as", "the", "basal", "amount", "of", "A549", "G2", "phase", "cells"], "h": {"id": "C0142915", "name": "C0142915#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0385469", "name": "C0385469#ent", "pos": [10, 11]}}
{"token": ["In", "addition", "to", "the", "cytokines", ",", "bacterial", "lipopolysaccharide", "C0175697#ent", "<e1>", ")", "and", "the", "C0022022#ent", "<e2>", "A23187", ",", "induce", "IL-6", "expression", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [13, 14]}}
{"token": ["The", "C0012634#ent", "<e1>", "very", "similar", ",", "together", "with", "the", "C0152027#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0152027", "name": "C0152027#ent", "pos": [9, 10]}}
{"token": ["Using", "the", "best", "cutoff", "C1366837#ent", "<e1>", "value", "to", "divide", "C1623038#ent", "<e2>", "into", "slowly", "and", "rapidly", "proliferating", "tissue", "subsets", ",", "the", "PCNA", "index", "was", "independently", "associated", "with", "serum", "albumin"], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [9, 10]}}
{"token": ["In", "Xenopus", "laevis", "the", "C0079429#ent", "<e1>", "encoding", "the", "elongation", "factor", "1-alpha", "C0059036#ent", "<e2>", "where", "O", "stands", "for", "oocyte", ",", "is", "expressed", "in", "oocytes", "and", "early", "embryos", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [11, 12]}}
{"token": ["The", "C0079429#ent", "<e1>", "which", "encodes", "the", "elongation", "factor", "1", "alpha", "C0059036#ent", "<e2>", "of", "the", "archaebacterium", "Thermoplasma", "acidophilum", "(", "tuf-gene", ")", "has", "been", "cloned", "and", "sequenced", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [10, 11]}}
{"token": ["The", "selective", "natriuretic", "activity", "A-66828", ",", "relative", "to", "C1417807#ent", "<e1>", ",", "suggests", "clinical", "utility", "for", "the", "treatment", "of", "C3854173#ent", "<e2>"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [18, 19]}}
{"token": ["The", "effect", "of", "the", "atrial", "natriuretic", "factor", "C1417807#ent", "<e1>", ")", "on", "early", "norepinephrine-induced", "C3854173#ent", "<e2>", "ARF", ")", "was", "investigated", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [13, 14]}}
{"token": ["C0023586#ent", "<e1>", "was", "more", "effective", "than", "dextrophan", "and", "C0015134#ent", "<e2>", "was", "substantially", "more", "effective", "than", "morphine", "in", "decreasing", "the", "spontaneous", "motility", "of", "4-day", "embryos", "."], "h": {"id": "C0023586", "name": "C0023586#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015134", "name": "C0015134#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "C1415932#ent", "<e1>", "contained", "chemokines", "(", "RANTES", "and", "C3887559#ent", "<e2>", ")", "and", "a", "cytokine", ",", "leukemia", "inhibitory", "factor", "exhibiting", "a", "strong", "anti-HIV-1", "activity", "in", "our", "model", "of", "cell-to-cell", "infection"], "h": {"id": "C1415932", "name": "C1415932#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3887559", "name": "C3887559#ent", "pos": [9, 10]}}
{"token": ["Naloxone", "and", "the", "internal", "standard", "C2343921#ent", "<e1>", ",", "are", "extracted", "from", "alkalinized", "blood", "into", "C3495432#ent", "<e2>", "subsequently", "back", "extracted", "into", "0.05", "%", "(", "v/v", ")", "phosphoric", "acid", "chromatographing", "on", "a", "reversed-phase", "system", "."], "h": {"id": "C2343921", "name": "C2343921#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3495432", "name": "C3495432#ent", "pos": [14, 15]}}
{"token": ["C1522405#ent", "<e1>", "beta-catenin", "signaling", "the", "inhibition", "of", "GSK3", ",", "resulting", "in", "reduced", "C1332803#ent", "<e2>", "phosphorylation", ",", "its", "stabilization", ",", "and", "subsequent", "accumulation", "in", "the", "nucleus", ",", "where", "it", "stimulates", "TCF/LEF-dependent", "gene", "transcription"], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [12, 13]}}
{"token": ["These", "diseases", "include", "severe", "forms", "of", "congenital", "muscular", "dystrophy", "C2827469#ent", "<e1>", ")", "such", "as", "Fukuyama", "type", "congenital", "muscular", "dystrophy", "C1414558#ent", "<e2>", ")", ",", "Muscle-Eye-Brain", "disease", "MEB", ")", "and", "Walker-Warburg", "syndrome", "WWS", ")", ",", "which", "are", "associated", "with", "brain", "and", "eye", "abnormalities"], "h": {"id": "C2827469", "name": "C2827469#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414558", "name": "C1414558#ent", "pos": [19, 20]}}
{"token": ["The", "association", "of", "congenital", "muscular", "dystrophy", "C2827469#ent", "<e1>", ")", "with", "type", "II", "lissencephaly", "ocular", "anomalies", "found", "in", "Fukuyama", "CMD", "C1414558#ent", "<e2>", ")", ",", "the", "Walker-Warburg", "syndrome", "WWS", ")", ",", "and", "muscle-eye-brain", "disease", "MEBD", ")", "."], "h": {"id": "C2827469", "name": "C2827469#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414558", "name": "C1414558#ent", "pos": [19, 20]}}
{"token": ["The", "protease", "antagonists", "TPCK", "and", "TLCK", ",", "the", "phospholipase", "inhibitors", "C0282331#ent", "<e1>", "and", "BPB", ",", "and", "the", "C3536851#ent", "<e2>", "verapamil", "were", "all", "inhibitory", "at", "micromolar", "concentrations", "."], "h": {"id": "C0282331", "name": "C0282331#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536851", "name": "C3536851#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "describe", "the", "detection", ",", "using", "the", "Jer58", "probe", ",", "which", "contains", "a", "24-bp", "tandem", "repeat", ",", "of", "polymorphism", "in", "the", "C2983560#ent", "<e1>", "seven", "different", "restriction", "C3541394#ent", "<e2>", "."], "h": {"id": "C2983560", "name": "C2983560#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [27, 28]}}
{"token": ["The", "phosphorylation", "of", "C0086376#ent", "<e1>", "such", "as", "replication", "protein", "A", "DNA", "polymerase-alpha", "-delta", ",", "replication", "factor", "C", "flap", "endonuclease", "1", "C0114615#ent", "<e2>", "to", "their", "inactivation", ",", "suggesting", "that", "phosphorylation", "is", "important", "in", "the", "prevention", "of", "re-replication", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0114615", "name": "C0114615#ent", "pos": [20, 21]}}
{"token": ["There", "is", "a", "broad", "range", "of", "compounds", "that", "bacteria", "can", "use", "for", "signaling", "purposes", ",", "including", "fatty", "acids", "C0030956#ent", "<e1>", ",", "N-acylated", "homoserine", "lactones", "and", "the", "signals", "collectively", "called", "autoinducer", "2", "C3887675#ent", "<e2>", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3887675", "name": "C3887675#ent", "pos": [31, 32]}}
{"token": ["The", "alpha", "2-adrenoceptor", "C0243192#ent", "<e1>", "such", "as", "clonidine", ",", "C0733381#ent", "<e2>", "and", "guanfacine", ",", "acts", "on", "RVLM", "to", "decrease", "sympathetic", "neuron", "activity", "and", "lower", "blood", "pressure"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0733381", "name": "C0733381#ent", "pos": [9, 10]}}
{"token": ["Allogenic", "aortic", "valves", "implantation", "was", "usually", "considered", "in", "our", "clinic", "for", "older", "patients", "patients", "with", "C1541923#ent", "<e1>", "the", "native", "or", "prosthetic", "valve", "young", "women", "reproductive", "age", "patients", "with", "C1414542#ent", "<e2>"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414542", "name": "C1414542#ent", "pos": [28, 29]}}
{"token": ["The", "clinical", "histories", "the", "cause", "for", "AR", "in", "34", "cases", ":", "11", "rheumatic", ",", "13", "C1541923#ent", "<e1>", "4", "congenital", ",", "4", "associated", "with", "aortic", "aneurysms", "2", "the", "C1414542#ent", "<e2>"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414542", "name": "C1414542#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", ",", "the", "reverse", "effect", "in", "the", "presence", "of", "excitotoxic", "levels", "of", "C0017789#ent", "<e1>", "exposure", ",", "where", "C1427699#ent", "<e2>", "attenuated", "the", "rise", "in", "[Ca(2+)](i", ")", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1427699", "name": "C1427699#ent", "pos": [18, 19]}}
{"token": ["Impaired", "glucose", "tolerance", "present", "in", "up", "to", "39", "%", "of", "C3469521#ent", "<e1>", "patients", ",", "and", "clinically", "apparent", "C0011849#ent", "<e2>", "is", "seen", "in", "approximately", "18", "%", "of", "the", "affected", "individuals", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "long-term", "ivermectin", "therapy", "C0029001#ent", "<e1>", "may", "not", "suffice", "to", "re-establish", "fully", "a", "balanced", "C3540579#ent", "<e2>", "and", "Th2", "immune", "responsiveness", "O.", "volvulus", "individuals", "."], "h": {"id": "C0029001", "name": "C0029001#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [15, 16]}}
{"token": ["Despite", "continuous", "anticoagulation", "C0982192#ent", "<e1>", "heparin", ")", "and", "warfarin", "sodium", "C0265374#ent", "<e2>", ")", ",", "a", "large", "pedunculated", "left", "ventricular", "thrombus", "was", "formed", "."], "h": {"id": "C0982192", "name": "C0982192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0265374", "name": "C0265374#ent", "pos": [10, 11]}}
{"token": ["Induction", "chemotherapy", "this", "study", "consisted", "of", "six", "courses", "of", "C1161438#ent", "<e1>", ",", "doxorubicin", ",", "and", "vincristine", "(", "C1332670#ent", "<e2>", ")", ",", "followed", "by", "intrathoracic", "and", "cranial", "irradiation"], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332670", "name": "C1332670#ent", "pos": [17, 18]}}
{"token": ["No", "C1334043#ent", "<e1>", "to", "novC", "was", "identified", "in", "the", "gene", "clusters", "clorobiocin", "and", "C0056424#ent", "<e2>", ",", "questioning", "the", "postulated", "involvement", "of", "novC", "in", "aminocoumarin", "biosynthesis"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0056424", "name": "C0056424#ent", "pos": [13, 14]}}
{"token": ["Our", "recent", "work", "has", "led", "to", "the", "identification", "of", "four", "novel", "C0086376#ent", "<e1>", "that", "recognize", "AR", "zinc-finger", "region", "(", "C1424868#ent", "<e2>", ")", "both", "in", "vivo", "in", "vitro"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1424868", "name": "C1424868#ent", "pos": [19, 20]}}
{"token": ["To", "localize", "the", "C0027203#ent", "<e1>", "within", "the", "C1823521#ent", "<e2>", ",", "the", "interaction", "of", "C1823521#ent", "<e2>", "and", "their", "substructures", "with", "rFNR-3D", "was", "further", "investigated", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [7, 8]}}
{"token": ["The", "results", "showed", "that", "as", "compared", "with", "the", "normal", "side", "both", "C0027203#ent", "<e1>", "activities", "significantly", "changed", "in", "motor", "neurons", "C1823521#ent", "<e2>", "group", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "the", "endothelium-independent", "relaxation", "response", "to", "isosorbide", "dinitrate", "C0375381#ent", "<e1>", ")", "was", "not", "affected", "by", "C0011849#ent", "<e2>", "or", "garlic", "treatment", "."], "h": {"id": "C0375381", "name": "C0375381#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [17, 18]}}
{"token": ["Marked", "induction", "and", "inhibition", "of", "the", "C0633225#ent", "<e1>", "especially", "in", "the", "C0001614#ent", "<e2>", "and", "to", "varying", "degrees", "in", "other", "brain", "regions", "was", "seen", "in", "HCH", "treated", "rats", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [11, 12]}}
{"token": ["The", "transmembrane", "protease", "receptor", "tissue", "factor", "TF", ")", "triggers", "coagulation", "by", "forming", "an", "enzymatic", "complex", "the", "serine", "protease", "factor", "VIIa", "C0268345#ent", "<e1>", ")", "that", "activates", "C2826078#ent", "<e2>", "the", "protease", "factor", "Xa", "Xa", ")", "."], "h": {"id": "C0268345", "name": "C0268345#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2826078", "name": "C2826078#ent", "pos": [25, 26]}}
{"token": ["The", "results", "indicate", "that", "allelic", "variation", "in", "C3810537#ent", "<e1>", "promoter", "activity", "be", "androgen", "dependent", "and", "interaction", "of", "C0017337#ent", "<e2>", "in", "androgen", "pathway", "influence", "the", "risk", "of", "BPH", "and", "PC", "in", "Singapore", "males", "."], "h": {"id": "C3810537", "name": "C3810537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}}
{"token": ["In", "initial", "evaluations", "of", "the", "prostate", "cancer", "antigen", "3", "PCA3", ")", "C0017337#ent", "<e1>", "vis-\u00e0-vis", "serum", "prostate-specific", "antigen", "(", "C3810537#ent", "<e2>", ")", "levels", ",", "the", "C0017337#ent", "<e1>", "offers", "great", "promise", "."], "h": {"id": "C3810537", "name": "C3810537#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["L-Arginine", "(", "L-arg", ")", "is", "C0025517#ent", "<e1>", "to", "nitric", "oxide", "NO", ")", "by", "inducible", "NO", "synthase", "C1417760#ent", "<e2>", ")", "or", "to", "urea", "and", "L-ornithine", "(", "L-orn", ")", "by", "arginase", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [16, 17]}}
{"token": ["The", "diverse", "intrarenal", "effects", "of", "the", "C0356622#ent", "<e1>", "(", "PG", ")", "are", "mediated", "by", "distinct", "C0086376#ent", "<e2>", "receptors", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["C1366564#ent", "<e1>", "levels", "did", "not", "change", "with", "episodes", "of", "C0004623#ent", "<e2>", "acute", "graft-versus-host", "disease"], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [9, 10]}}
{"token": ["In", "this", "report", "we", "have", "analyzed", "C1516876#ent", "<e1>", "and", "biochemically", "the", "interaction", "of", "C1414091#ent", "<e2>", "with", "RPA", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414091", "name": "C1414091#ent", "pos": [13, 14]}}
{"token": ["These", "data", "reconfirm", "that", "in", "Blacks", "with", "C0002312#ent", "<e1>", "proportion", "of", "C2697529#ent", "<e2>", "is", "lower", "and", "the", "severity", "of", "anaemia", "is", "less", "than", "in", "certain", "other", "racial", "groups", "e.g.", "Southeast", "Asians"], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C2697529", "name": "C2697529#ent", "pos": [11, 12]}}
{"token": ["Despite", "the", "similarity", "of", "these", "two", "mutations", ",", "the", "alpha", "2", "mutant", "results", "in", "a", "more", "severe", "loss", "of", "alpha-globin", "synthesis", "a", "more", "severe", "clinical", "C0002312#ent", "<e1>", "phenotype", "than", "the", "corresponding", "C2697529#ent", "<e2>"], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [25, 26]}, "relation": "disease_has_associated_gene", "t": {"id": "C2697529", "name": "C2697529#ent", "pos": [31, 32]}}
{"token": ["The", "C1705523#ent", "<e1>", "expression", "was", "up-regulated", "by", "indomethacin", ",", "C0538927#ent", "<e2>", "and", "dexamethasone", "in", "both", "D1-cells", "and", "hBMSCs", "."], "h": {"id": "C1705523", "name": "C1705523#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [9, 10]}}
{"token": ["Fatigue", "and", "C0023380#ent", "<e1>", ",", "common", "symptoms", "in", "C0042749#ent", "<e2>", ",", "have", "been", "attributed", "to", "many", "factors", "."], "h": {"id": "C0023380", "name": "C0023380#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042749", "name": "C0042749#ent", "pos": [8, 9]}}
{"token": ["Also", ",", "this", "alteration", "could", "be", "accounted", "for", "by", "an", "increased", "phosphorylation", "of", "a", "56-kilodalton", "soluble", "C1334332#ent", "<e1>", "was", "resolved", "as", "a", "minor", "protein-staining", "band", "after", "C0037506#ent", "<e2>", "slab", "PAGE", "."], "h": {"id": "C1334332", "name": "C1334332#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [26, 27]}}
{"token": ["We", "determined", "that", "C1332416#ent", "<e1>", "was", "significantly", "increased", "by", "overexpression", "of", "an", "active", "C1367307#ent", "<e2>", "(", "Stat3-C", ")", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "C1367307#ent", "<e1>", "inhibition", "markedly", "decreased", "C1332416#ent", "<e2>", "expression", ",", "and", "forced", "expression", "of", "C1332416#ent", "<e2>", "rescued", "AGS", "cells", "from", "apoptosis", "induced", "by", "C1367307#ent", "<e1>", "inhibition", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [2, 3]}}
{"token": ["The", "antiapoptotic", "proteins", "Mcl-1", "and", "C1332416#ent", "<e1>", ",", "which", "are", "encoded", "in", "target", "genes", "of", "C1367307#ent", "<e2>", ",", "were", "down-regulated", "by", "indirubin", "derivatives", ",", "followed", "by", "induction", "of", "apoptosis", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [15, 16]}}
{"token": ["The", "highly", "specific", "inhibitors", "C0082782#ent", "<e1>", "(", "for", "protein", "kinase", "A", "and", "calphostin", "C", "for", "C1259877#ent", "<e2>", "only", "inhibited", "partially", "the", "morphological", "alterations", "."], "h": {"id": "C0082782", "name": "C0082782#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [15, 16]}}
{"token": ["Single", "nucleotide", "polymorphisms", "C1366555#ent", "<e1>", "DPYD", ")", "induces", "C0058126#ent", "<e2>", "DPD", ")", "deficiency", "resulting", "in", "increased", "activity", "of", "5-fluorouracil", "derivatives"], "h": {"id": "C1366555", "name": "C1366555#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0058126", "name": "C0058126#ent", "pos": [8, 9]}}
{"token": ["Variations", "in", "C1366555#ent", "<e1>", "activity", "may", "result", "from", "alterations", "at", "the", "transcriptional", "level", "the", "C0058126#ent", "<e2>"], "h": {"id": "C1366555", "name": "C1366555#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0058126", "name": "C0058126#ent", "pos": [14, 15]}}
{"token": ["It", "has", "been", "demonstrated", "that", "the", "regulation", "of", "the", "C1366555#ent", "<e1>", "an", "important", "role", "in", "the", "determination", "of", "the", "enzyme", "activity", "C0058126#ent", "<e2>"], "h": {"id": "C1366555", "name": "C1366555#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0058126", "name": "C0058126#ent", "pos": [21, 22]}}
{"token": ["E-cadherin", ",", "beta-catenin", ",", "C0007427#ent", "<e1>", "matrix", "metalloproteinase", "(MMP)-2", ",", "MMP-9", ",", "C0003015#ent", "<e2>", "metalloproteinase", "(TIMP)-1", "and", "TIMP-2", "are", "all", "invasion-related", "proteins", "."], "h": {"id": "C0007427", "name": "C0007427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "clones", "were", "found", "corresponding", "to", "the", "C0033607#ent", "<e1>", "to", "the", "C3536868#ent", "<e2>", "GAPDH", ")", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536868", "name": "C3536868#ent", "pos": [13, 14]}}
{"token": ["Direct", "costs", "of", "treatment", "per", "C1850938#ent", "<e1>", "were", "lower", "in", "the", "C3814419#ent", "<e2>", "than", "PC", "group", "(", "median", ",", "3.78", "vs", "4.41", "Euro", ";", "p<0.05", ")", "."], "h": {"id": "C1850938", "name": "C1850938#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3814419", "name": "C3814419#ent", "pos": [11, 12]}}
{"token": ["Both", "BRCA1", "and", "C0598034#ent", "<e1>", "have", "also", "been", "implicated", "in", "transcription", "by", "C0035679#ent", "<e2>", "for", "both", "proteins", "have", "domains", "which", ",", "when", "tethered", "adjacent", "to", "a", "promoter", ",", "can", "activate", "transcription", "."], "h": {"id": "C0598034", "name": "C0598034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [12, 13]}}
{"token": ["We", "concluded", "that", "biosynthetic", "growth", "hormone", "from", "mammalian", "cells", "a", "safety", "C1254351#ent", "<e1>", ",", "and", "that", "patients", "with", "C0271561#ent", "<e2>", "be", "treated", "with", "in", "order", "to", "improve", "their", "final", "height", "expectancy"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0271561", "name": "C0271561#ent", "pos": [18, 19]}}
{"token": ["The", "inhibitory", "effects", "of", "C1417815#ent", "<e1>", "on", "both", "basal", "levels", "cyclic", "AMP", "C0917964#ent", "<e2>", "increase", "of", "cyclic", "AMP", "not", "reversed", "by", "the", "application", "of", "alpha-trinositol", "(", "10(-8)-10(-6", ")", "M", ")", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "C1417815#ent", "<e1>", "significantly", "inhibited", "the", "C0917964#ent", "<e2>", "cAMP", "production", "in", "smooth", "muscle", "not", "in", "endothelial", "cell", "cultures"], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [7, 8]}}
{"token": ["In", "perfused", "glands", "C1417815#ent", "<e1>", "inhibited", "secretion", "stimulated", "by", "vasoactive", "intestinal", "peptide", "VIP", ")", ",", "C0917964#ent", "<e2>", ",", "or", "adenosine", "3',5'-cyclic", "monophosphate", "cAMP", ")", "and", "theophylline", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [15, 16]}}
{"token": ["Neither", "the", "5-hydroxytryptamine", "(", "5-HT", ")", "receptor", "blocker", ",", "C0010620#ent", "<e1>", ",", "nor", "the", "inhibitor", "of", "5-HT", "synthesis", ",", "C0030135#ent", "<e2>", "(", "PCPA", ")", ",", "modified", "dopamine-induced", "hypothermia", "."], "h": {"id": "C0010620", "name": "C0010620#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030135", "name": "C0030135#ent", "pos": [19, 20]}}
{"token": ["Further", "study", "of", "impaired", "cell-mediated", "immunity", "C0005398#ent", "<e1>", "improve", "our", "understanding", "of", "the", "immunological", "status", "patients", "with", "C0022354#ent", "<e2>", "cholestatic", "liver", "diseases"], "h": {"id": "C0005398", "name": "C0005398#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [17, 18]}}
{"token": ["ERCP", "excluded", "C0005398#ent", "<e1>", "thus", "avoided", "unnecessary", "surgical", "exploration", "forty-nine", "patients", "with", "C0022354#ent", "<e2>"], "h": {"id": "C0005398", "name": "C0005398#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [12, 13]}}
{"token": ["The", "C0022658#ent", "<e1>", "consists", "of", "C0022672#ent", "<e2>", "acute", "tubulointerstitial", "nephritis", "pre-renal", "type", "renal", "failure", "obstructive", "renal", "failure", "chronic", "tubulointerstitial", "nephritis", "glomerular", "damage"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0022672", "name": "C0022672#ent", "pos": [5, 6]}}
{"token": ["Reproducibility", "of", "the", "volume", "measurement", "tested", "by", "repeating", "measurements", "5", "times", "on", "5", "patient", "samples", "of", "amygdalohippocampal", "complex", "in", "C3538946#ent", "<e1>", ",", "and", "3", "times", "on", "4", "samples", "in", "C1537503#ent", "<e2>", "."], "h": {"id": "C3538946", "name": "C3538946#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1537503", "name": "C1537503#ent", "pos": [29, 30]}}
{"token": ["The", "mean", "coefficient", "of", "variation", "amygdalohippocampal", "volume", "was", "6.9", "+", "/-", "3.2", "%", "in", "C3538946#ent", "<e1>", "and", "3.9", "+", "/-", "2.0", "in", "C1537503#ent", "<e2>", "."], "h": {"id": "C3538946", "name": "C3538946#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1537503", "name": "C1537503#ent", "pos": [22, 23]}}
{"token": ["Certain", "members", "of", "the", "C2698694#ent", "<e1>", "family", "contain", "C3274827#ent", "<e2>", "motifs", "that", "mediate", "interactions", "with", "other", "signaling", "molecules", "thus", "linking", "GPCR-dependent", "and", "GPCR-independent", "signaling", "pathways", "."], "h": {"id": "C2698694", "name": "C2698694#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3274827", "name": "C3274827#ent", "pos": [8, 9]}}
{"token": ["We", "synthesized", "two", "isomeric", "compounds", "on", "the", "structure", "of", "C1846989#ent", "<e1>", ",", "in", "which", "the", "histidine", "residue", "replaced", "by", "3,5-di-tert-butyltyrosine", "(", "C1413925#ent", "<e2>", ")", ",", "a", "phenolic", "amino", "acid", "traps", "reactive", "oxygen", "species"], "h": {"id": "C1846989", "name": "C1846989#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413925", "name": "C1413925#ent", "pos": [21, 22]}}
{"token": ["We", "suggest", "a", "novel", "role", "for", "CNBP", "as", "a", "C3273678#ent", "<e1>", "that", "interacts", "with", "Pnt2", "in", "the", "negative", "C1710463#ent", "<e2>", "JCV(E", ")", "."], "h": {"id": "C3273678", "name": "C3273678#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [18, 19]}}
{"token": ["C1422288#ent", "<e1>", "and", "LSM4", ",", "but", "not", "other", "LSM", "C1417679#ent", "<e2>", ",", "act", "as", "allele-specific", ",", "low-copy", "suppressors", "of", "mutations", "in", "Lsm8p", "."], "h": {"id": "C1422288", "name": "C1422288#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}}
{"token": ["As", "evidenced", "by", "the", "nature", "of", "the", "late", "peptidoglycan", "and", "by", "quantification", "of", "d", ",", "C0660025#ent", "<e1>", "activities", ",", "the", "vancomycin", "resistance", "C1417679#ent", "<e2>", "were", "efficiently", "expressed", "in", "both", "strains", "."], "h": {"id": "C0660025", "name": "C0660025#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [22, 23]}}
{"token": ["A", "case", "history", "C0877055#ent", "<e1>", "AGEP", ")", "following", "C0076110#ent", "<e2>", "reported", "."], "h": {"id": "C0877055", "name": "C0877055#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [8, 9]}}
{"token": ["The", "dopamine", "antagonist", "C0031935#ent", "<e1>", ",", "stimulated", "release", "of", "C0016424#ent", "<e2>", "."], "h": {"id": "C0031935", "name": "C0031935#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [9, 10]}}
{"token": ["A", "double-blind", ",", "multicenter", "study", "conducted", "to", "evaluate", "and", "compare", "the", "safety", "and", "efficacy", "of", "desoximetasone", "gel", "%", "and", "C0016299#ent", "<e1>", "%", "in", "patients", "with", "C0033860#ent", "<e2>"], "h": {"id": "C0016299", "name": "C0016299#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [25, 26]}}
{"token": ["In", "this", "regard", ",", "GGTase-I", "is", "similar", "to", "the", "related", "C0138837#ent", "<e1>", "FTase", ")", ";", "the", "latter", "C0027203#ent", "<e2>", "also", "requires", "Mg2", "+", "for", "activity", "."], "h": {"id": "C0138837", "name": "C0138837#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}}
{"token": ["C1418773#ent", "<e1>", "of", "OPFPt", "by", "C0072642#ent", "<e2>", "."], "h": {"id": "C1418773", "name": "C1418773#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072642", "name": "C0072642#ent", "pos": [5, 6]}}
{"token": ["This", "review", "is", "a", "brief", "analysis", "of", "gene", "knockout", "models", "C0023374#ent", "<e1>", "Lowe", "syndrome", "X-linked", "adrenoleukodystrophy", "Fabry", "disease", "galactosemia", ",", "glycogen", "storage", "disease", "type", "II", "metachromatic", "leukodystrophy", "and", "C0039373#ent", "<e2>", "which", "produce", "a", "biochemical", "model", "disease", "but", "often", "do", "not", "reproduce", "clinical", "symptoms"], "h": {"id": "C0023374", "name": "C0023374#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039373", "name": "C0039373#ent", "pos": [28, 29]}}
{"token": ["Here", ",", "we", "developed", "replication-competent", "vaccines", "EBOV", "and", "MARV", "based", "on", "attenuated", "C0266999#ent", "<e1>", "expressing", "either", "the", "EBOV", "glycoprotein", "or", "C0072522#ent", "<e2>"], "h": {"id": "C0266999", "name": "C0266999#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [20, 21]}}
{"token": ["We", "generated", "a", "C0266999#ent", "<e1>", "VSV-E2", ")", "encoding", "the", "bovine", "viral", "diarrhea", "virus", "BVDV", ")", "C0072522#ent", "<e2>", "the", "VSV-G", "protein", "signal", "peptide", "."], "h": {"id": "C0266999", "name": "C0266999#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [15, 16]}}
{"token": ["This", "family", "of", "C0086376#ent", "<e1>", "was", "thought", "to", "consist", "of", "four", "members", ",", "xanthine", "oxidoreductase", "C1412433#ent", "<e2>", "AOX1", ")", ",", "and", "the", "aldehyde", "oxidase", "homologues", "1", "2", "(", "AOH1", "and", "AOH2", ",", "respectively", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412433", "name": "C1412433#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "this", "study", "suggests", "that", "the", "beneficial", "effect", "of", "this", "C1254351#ent", "<e1>", "on", "the", "walking", "capacity", "of", "patients", "with", "C0085096#ent", "<e2>", "not", "due", "to", "a", "direct", "vasoactive", "action"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [20, 21]}}
{"token": ["In", "vitro", "in", "vivo", "data", "were", "consistent", "with", "observations", ":", "C0392213#ent", "<e1>", "of", "LY309887", "was", "less", "extensive", "compared", "to", "C0048852#ent", "<e2>", "and", "livers", "of", "mice", "accumulated", "fewer", "polyglutamates", "of", "LY309887", "than", "polyglutamates", "of", "C0048852#ent", "<e2>", "."], "h": {"id": "C0392213", "name": "C0392213#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0048852", "name": "C0048852#ent", "pos": [19, 20]}}
{"token": ["In", "vitro", "in", "vivo", "data", "were", "consistent", "with", "observations", ":", "polyglutamation", "of", "LY309887", "was", "less", "extensive", "compared", "to", "C0048852#ent", "<e1>", "and", "livers", "of", "mice", "accumulated", "fewer", "C0392213#ent", "<e2>", "of", "LY309887", "than", "C0392213#ent", "<e2>", "of", "C0048852#ent", "<e1>", "."], "h": {"id": "C0392213", "name": "C0392213#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0048852", "name": "C0048852#ent", "pos": [18, 19]}}
{"token": ["Conversely", ",", "C1538265#ent", "<e1>", "activity", "was", "confined", "to", "the", "C1173652#ent", "<e2>", "+", "subset", "."], "h": {"id": "C1538265", "name": "C1538265#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1173652", "name": "C1173652#ent", "pos": [9, 10]}}
{"token": ["p62(dok", ")", "associates", "with", "the", "Ras", "GTPase-activating", "protein", "C2984552#ent", "<e1>", ")", ",", "but", "only", "when", "C1707620#ent", "<e2>", "tyrosine", "phosphorylated", "."], "h": {"id": "C2984552", "name": "C2984552#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1707620", "name": "C1707620#ent", "pos": [15, 16]}}
{"token": ["Xenopus", "C1524023#ent", "<e1>", "consists", "of", "710", "C3539946#ent", "<e2>", "contains", "four", "kringle", "domains", "serine", "protease-like", "structure", "just", "like", "mammalian", "C1524023#ent", "<e1>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [1, 2]}}
{"token": ["These", "results", "demonstrate", "that", "relatively", "enhanced", "levels", "of", "C2984141#ent", "<e1>", "contribute", "to", "an", "increased", "C0035690#ent", "<e2>"], "h": {"id": "C2984141", "name": "C2984141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035690", "name": "C0035690#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", "our", "study", "showed", "that", "adrenal", "steroid", "to", "C1704793#ent", "<e1>", "increases", "in", "C0028326#ent", "<e2>", "long-term", "treatment", "with", "high", "GH", "doses", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028326", "name": "C0028326#ent", "pos": [13, 14]}}
{"token": ["Endogenous", "mRNA", "expression", "of", "two", "known", "estrogen-responsive", "genes", "cathepsin", "D", "C1334095#ent", "<e1>", ",", "was", "weakly", "induced", "by", "C2936882#ent", "<e2>", "in", "ERbeta1", "and", "ERbetacx/beta2", "transformants", "compared", "with", "parental", "cells"], "h": {"id": "C1334095", "name": "C1334095#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [17, 18]}}
{"token": ["We", "report", "here", "a", "patient", "of", "myasthenia", "gravis", "associated", "with", "C0023787#ent", "<e1>", "a", "variant", "form", "of", "C0271694#ent", "<e2>", "and", "hypocomplementemia", "."], "h": {"id": "C0023787", "name": "C0023787#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0271694", "name": "C0271694#ent", "pos": [16, 17]}}
{"token": ["The", "C0025237#ent", "<e1>", "a", "rare", "connective", "tissue", "disorder", "by", "specific", "facial", "features", "(", "small", "facial", "bones", "C0015300#ent", "<e2>", ",", "hypertelorism", ",", "full", "checks", "and", "small", "mandible", ",", "skeletal", "defects", "short", "stature"], "h": {"id": "C0025237", "name": "C0025237#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0015300", "name": "C0015300#ent", "pos": [16, 17]}}
{"token": ["Caffeine", "(", "5", "mM", ")", "abolishes", "Vos", "and", "Ios", "and", "increases", "C1256378#ent", "<e1>", "and", "Iex", "(", "as", "C0393003#ent", "<e2>", "does", ")", ",", "and", "adding", "C0393003#ent", "<e2>", "slightly", "increased", "C1256378#ent", "<e1>", "and", "Iex", "."], "h": {"id": "C0393003", "name": "C0393003#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1256378", "name": "C1256378#ent", "pos": [11, 12]}}
{"token": ["A", "double-blind", "trial", "a", "new", "antihistaminic", "agent", "oxatomide", ")", "with", "C0008929#ent", "<e1>", "was", "carried", "out", "in", "30", "patients", "with", "C0042109#ent", "<e2>"], "h": {"id": "C0008929", "name": "C0008929#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [19, 20]}}
{"token": ["Two", "C0001019#ent", "<e1>", "thlA", "and", "C0018482#ent", "<e2>", ")", "have", "been", "cloned", "and", "sequenced", "from", "Clostridium", "acetobutylicum", "DSM", "792", "showing", "high", "homology", "to", "each", "other", "and", "to", "thiolases", "of", "PHA-synthesizing", "bacteria", "."], "h": {"id": "C0001019", "name": "C0001019#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018482", "name": "C0018482#ent", "pos": [5, 6]}}
{"token": ["Isolated", "C0342388#ent", "<e1>", "an", "uncommon", "cause", "of", "C0948387#ent", "<e2>", "accompaniment", "with", "primary", "empty", "has", "been", "reported", "in", "several", "cases", "."], "h": {"id": "C0342388", "name": "C0342388#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0948387", "name": "C0948387#ent", "pos": [7, 8]}}
{"token": ["C0034342#ent", "<e1>", "yeast", "(", "YPDC", ",", "C0029282#ent", "<e2>", "exhibits", "a", "marked", "lag", "phase", "in", "the", "progress", "curves", "of", "product", "(", "acetaldehyde", ")", "formation", "."], "h": {"id": "C0034342", "name": "C0034342#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [6, 7]}}
{"token": ["Lycasin", "80/55", ",", "hydrogenated", "starch", "hydrolysate", ",", "was", "converted", "by", "purified", "C0002272#ent", "<e1>", "glucose", "and", "C0037688#ent", "<e2>", "."], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [15, 16]}}
{"token": ["Coexisting", "C0036916#ent", "<e1>", "infections", "and", "C0042251#ent", "<e2>", "were", "also", "assessed", ",", "and", "detailed", "behavioral", "information", "was", "collected", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0042251", "name": "C0042251#ent", "pos": [5, 6]}}
{"token": ["These", "results", "suggest", "that", "a", "population", "of", "C1334148#ent", "<e1>", "in", "brain", "may", "be", "attached", "to", "an", "C0597298#ent", "<e2>", "of", "ankyrin", "."], "h": {"id": "C1334148", "name": "C1334148#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [16, 17]}}
{"token": ["We", "have", "analyzed", "the", "myocardial", "lipids", "an", "infant", "with", "C0268596#ent", "<e1>", "GAII", ")", "who", "died", "from", "C0018802#ent", "<e2>", "of", "five", "infants", "who", "died", "suddenly", "from", "indeterminate", "causes", "(", "sudden", "infant", "death", "syndrome", "SIDS", ")", "."], "h": {"id": "C0268596", "name": "C0268596#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}}
{"token": ["We", "report", "on", "two", "cases", "of", "C0158995#ent", "<e1>", "one", "with", "Blackfan-Diamond", "anemia", "one", "with", "C0002876#ent", "<e2>", "presenting", "with", "increased", "nuchal", "translucency", "12", "weeks", "of", "gestation", "."], "h": {"id": "C0158995", "name": "C0158995#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0002876", "name": "C0002876#ent", "pos": [14, 15]}}
{"token": ["C0004773#ent", "<e1>", "be", "considered", "in", "the", "differential", "diagnosis", "unusual", "myositis", "or", "C0029408#ent", "<e2>", "in", "children", "."], "h": {"id": "C0004773", "name": "C0004773#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [11, 12]}}
{"token": ["We", "did", ",", "however", ",", "demonstrate", "a", "dose-dependent", "decrease", "in", "C1366571#ent", "<e1>", "release", "and", "C1366571#ent", "<e1>", "mRNA", "induction", "in", "RSV-infected", "epithelial", "treated", "with", "C0003402#ent", "<e1>", "DMSO", ")", "or", "5,5-dimethyl-1-pyrroline-N-oxide", "(", "DMPO", ")", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [23, 24]}}
{"token": ["These", "are", "the", "first", "reported", "cases", "of", "the", "acute", "use", "of", "intraventricular", "C0078956#ent", "<e1>", "after", "Guglielmi", "detachable", "coiling", "treatment", "for", "C0162869#ent", "<e2>"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0162869", "name": "C0162869#ent", "pos": [20, 21]}}
{"token": ["The", "pathology", "of", "the", "parathyroid", "glands", "two", "cases", "in", "which", "hyperparathyroidism", "was", "associated", "with", "C0022661#ent", "<e1>", "10", "in", "which", "the", "association", "was", "with", "the", "C0024523#ent", "<e2>", "described", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [24, 25]}}
{"token": ["The", "DMD", "chemoselectivity", "favors", "the", "oxidation", "of", "sulfur", "compounds", "C0038761#ent", "<e1>", "in", "a", "few", "minutes", ",", "whereas", "C1418199#ent", "<e2>", "remain", "unreacted", "."], "h": {"id": "C0038761", "name": "C0038761#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418199", "name": "C1418199#ent", "pos": [17, 18]}}
{"token": ["C0016957#ent", "<e1>", "C2-Cer", "and", "C2-Cer", "suppressed", "the", "allogeneic", "mixed", "leukocyte", "reaction", "C1705928#ent", "<e2>", ")", "responses", ",", "but", "alpha-galactosylated", "C2-Cer", "stimulated", "the", "C1705928#ent", "<e2>", "response", "."], "h": {"id": "C0016957", "name": "C0016957#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705928", "name": "C1705928#ent", "pos": [11, 12]}}
{"token": ["In", "BMP2-treated", "MSCs", ",", "C3253705#ent", "<e1>", "levels", "of", "15", "microMu", "were", "found", "to", "increase", "alkaline", "phosphatase", "C1412624#ent", "<e2>", ")", "activity", "and", "calcium", "deposition", "which", "were", "the", "markers", "of", "osteoblastic", "differentiation"], "h": {"id": "C3253705", "name": "C3253705#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412624", "name": "C1412624#ent", "pos": [16, 17]}}
{"token": ["The", "data", "indicate", "an", "influence", "of", "common", "C1412058#ent", "<e1>", "functional", "polymorphisms", "on", "age", "of", "symptom", "onset", "in", "C0010068#ent", "<e2>", "patients", "."], "h": {"id": "C1412058", "name": "C1412058#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [17, 18]}}
{"token": ["Preincubation", "with", "C1421531#ent", "<e1>", "however", ",", "altered", "the", "half-life", "of", "efflux", "of", "C1413043#ent", "<e2>", "+", "from", "these", "vesicles", "only", "marginally", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["Treatment", "of", "bovine", "pulmonary", "artery", "smooth", "muscle", "the", "O2", "*", "-", "generating", "system", "hypoxanthine", "C1421531#ent", "<e1>", "stimulated", "MMP-2", "activity", "PKC", "activity", ";", "and", "inhibited", "Na+", "dependent", "C1413043#ent", "<e2>", "+", "uptake", "in", "the", "microsomes", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [26, 27]}}
{"token": ["C1421531#ent", "<e1>", "inhibition", "with", "allopurinol", "modulates", "reactive", "oxygen", "species", "production", "and", "intracellular", "C1413043#ent", "<e2>", "+", "overload", "in", "hypoxia-reoxygenation-injured", "neonatal", "rat", "cardiomyocytes", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["The", "false", "positives", "of", "two", "cases", "of", "C0030305#ent", "<e1>", "normal", "gallbladders", "one", "case", "of", "coincidental", "C2609268#ent", "<e2>", "duodenal", "ulcer"], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C2609268", "name": "C2609268#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "a", "drug-drug", "interaction", "itraconazole", "and", "C0674428#ent", "<e1>", "in", "a", "patient", "with", "disseminated", "histoplasmosis", "C0001175#ent", "<e2>", "AIDS", ")", "."], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [15, 16]}}
{"token": ["We", "found", "that", "octanoate", "significantly", "suppressed", "the", "esterification", "of", "C0028928#ent", "<e1>", "into", "triglycerides", "(", "C0039902#ent", "<e2>", ")", "in", "both", "3T3-L1", "and", "human", "adipocytes", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [14, 15]}}
{"token": ["Hepatocytes", "were", "incubated", "with", "0.75", "mm", "C0028928#ent", "<e1>", ",", "the", "media", "were", "harvested", ",", "and", "triacylglycerol", "(", "C0039902#ent", "<e2>", ")", ",", "PC", ",", "apolipoprotein", "(apo)", "B100", "and", "apoB48", "were", "isolated", "and", "quantified", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [17, 18]}}
{"token": ["When", "J774", "murine", "macrophages", "were", "incubated", "with", "either", "VLDL", "or", "C0028928#ent", "<e1>", "their", "content", "of", "both", "ADRP", "and", "triacylglycerol", "(", "C0039902#ent", "<e2>", ")", "increased", "3-", "to", "4-fold", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [20, 21]}}
{"token": ["Mutations", "in", "C1859807#ent", "<e1>", "cause", "some", "recessive", "familial", "forms", "C1862939#ent", "<e2>", "ALS", ")", "but", "the", "function", "of", "C1859807#ent", "<e1>", "is", "poorly", "understood", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1859807", "name": "C1859807#ent", "pos": [2, 3]}}
{"token": ["We", "have", "initially", "identified", "a", "mutation", "in", "C1859807#ent", "<e1>", "as", "a", "causative", "for", "a", "juvenile", "autosomal", "recessive", "form", "C1862939#ent", "<e2>", "ALS", ")", ",", "termed", "C1859807#ent", "<e1>", "(", "OMIM", "205100", ")", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1859807", "name": "C1859807#ent", "pos": [7, 8]}}
{"token": ["Atorvastatin", "reduced", "activated", "RhoA-induced", "serum", "response", "factor-mediated", "reporter", "activity", "in", "HEK293", "cells", "indicating", "that", "C0286651#ent", "<e1>", "inhibits", "Rho", "signaling", "and", "this", "was", "reversed", "by", "C0210158#ent", "<e2>", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0210158", "name": "C0210158#ent", "pos": [24, 25]}}
{"token": ["Together", ",", "these", "findings", "suggest", "that", "C0165264#ent", "<e1>", ",", "a", "new", "member", "of", "the", "C0031977#ent", "<e2>", "group", "of", "cognition", "enhancers", "could", "be", "a", "good", "therapeutic", "tool", "neuropathic", "pain"], "h": {"id": "C0165264", "name": "C0165264#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031977", "name": "C0031977#ent", "pos": [14, 15]}}
{"token": ["This", "resulted", "from", "acute", "ingestion", "paroxetine", ",", "a", "selective", "C0162758#ent", "<e1>", "and", "moclobemide", ",", "a", "C0026457#ent", "<e2>"], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026457", "name": "C0026457#ent", "pos": [15, 16]}}
{"token": ["A", "substantial", "number", "of", "patients", "with", "panic", "disorder", "agoraphobia", "may", "remain", "symptomatic", "after", "standard", "treatment", "including", "selective", "C0162758#ent", "<e1>", "tricyclic", "antidepressants", "benzodiazepines", ",", "or", "irreversible", "C0026457#ent", "<e2>", "."], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0026457", "name": "C0026457#ent", "pos": [25, 26]}}
{"token": ["Selective", "C0162758#ent", "<e1>", ",", "venlafaxin", "and", "C0026457#ent", "<e2>", "constitute", "a", "beneficial", "choice", "."], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026457", "name": "C0026457#ent", "pos": [6, 7]}}
{"token": ["These", "findings", "indicate", "that", "left", "ventricular", "chamber", "size", "is", "an", "important", "factor", "in", "the", "response", "to", "C0020223#ent", "<e1>", "in", "patients", "with", "severe", "C0018802#ent", "<e2>"], "h": {"id": "C0020223", "name": "C0020223#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [22, 23]}}
{"token": ["Evaluation", "of", ":", "Combination", "of", "isosorbide", "dinitrate", "and", "C0020223#ent", "<e1>", "in", "blacks", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0020223", "name": "C0020223#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["We", "excluded", "40", "patients", "affected", "by", "C0221376#ent", "<e1>", ",", "uterine", "fibroids", "uterine", "malformations", "endocrinological", "and", "immunological", "diseases", "C0035078#ent", "<e2>", "cytogenetical", "alterations"], "h": {"id": "C0221376", "name": "C0221376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [17, 18]}}
{"token": ["C0632192#ent", "<e1>", "rather", "than", "C0074405#ent", "<e2>", "can", "account", "for", "the", "potent", "physiological", "effect", "sesame", "seeds", "in", "increasing", "hepatic", "fatty", "acid", "oxidation", "previously", "."], "h": {"id": "C0632192", "name": "C0632192#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0074405", "name": "C0074405#ent", "pos": [4, 5]}}
{"token": ["CD156", "(", "C1314771#ent", "<e1>", ")", "is", "part", "of", "the", "C1332023#ent", "<e2>", "proteins", "with", "the", "catalytic", "site", "consensus", "sequence", "metalloprotease", "and", "disintegrins", "."], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [2, 3]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C1332023", "name": "C1332023#ent", "pos": [9, 10]}}
{"token": ["C0840564#ent", "<e1>", "a", "complication", "of", "umbilical", "catheterization", "a", "newborn", "with", "urinary", "ascites", "C0476273#ent", "<e2>", "hematuria", "is", "presented", "and", "discussed", "."], "h": {"id": "C0840564", "name": "C0840564#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [12, 13]}}
{"token": ["C0074405#ent", "<e1>", "was", "found", "to", "inhibit", "this", "C0027203#ent", "<e2>", "as", "measured", "in", "both", "spectrophotometric", "and", "radioactive", "assays"], "h": {"id": "C0074405", "name": "C0074405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}}
{"token": ["C3853627#ent", "<e1>", "reduced", "the", "incidence", "of", "cleft", "palates", "by", "C0012386#ent", "<e2>", "given", "on", "Days", "11", "and", "12", "from", "34.9", "to", "20.3", "%", "(", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C3853627", "name": "C3853627#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012386", "name": "C0012386#ent", "pos": [9, 10]}}
{"token": ["We", "investigated", "the", "relationship", "between", "polymorphisms", "in", "the", "first", "exon", "of", "the", "C0812381#ent", "<e1>", "which", "encodes", "for", "mannose", "binding", "lectin", "MBL", ")", "and", "C1426204#ent", "<e2>"], "h": {"id": "C0812381", "name": "C0812381#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1426204", "name": "C1426204#ent", "pos": [23, 24]}}
{"token": ["The", "remaining", "six", "enzymes", ",", "fumarase", ",", "glucose", "phosphate", "isomerase", "glutamate", "dehydrogenase", "NADP", ")", ",", "C0022157#ent", "<e1>", "NADP", ")", ",", "malate", "dehydrogenase", "and", "C0041078#ent", "<e2>", "could", "potentially", "be", "used", "to", "distinguish", "the", "different", "biological", "species"], "h": {"id": "C0022157", "name": "C0022157#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041078", "name": "C0041078#ent", "pos": [23, 24]}}
{"token": ["DNA", "sequence", "analysis", "database", "search", "showed", "that", "they", "encode", "8", "proteins", "which", "are", "highly", "C1512488#ent", "<e1>", "to", "40S", "ribosomal", "proteins", "and", "60S", "riobosomal", "proteins", "L7", "L18a", ",", "C1335638#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335638", "name": "C1335638#ent", "pos": [27, 28]}}
{"token": ["Other", "studies", "suggest", "that", "various", "anti-inflammatory", "drugs", "including", "acetylsalicyclic", "acid", "auranofin", "and", "C0011777#ent", "<e1>", ",", "can", "also", "facilitate", "C3890018#ent", "<e2>", "expression", "in", "macrophages", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [18, 19]}}
{"token": ["114:93", "-", "98", ",", "1983", ")", ",", "that", "C0011777#ent", "<e1>", "inhibits", "the", "alterations", "in", "heat", "shock", "protein", "C3890018#ent", "<e2>", ")", "and", "glucose-regulated", "protein", "GRP", ")", "synthesis", "caused", "by", "glucose", "deprivation", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [17, 18]}}
{"token": ["We", "showed", "earlier", "that", "most", "patients", "with", "C0011616#ent", "<e1>", "to", "corticosteroids", "show", "cross-reactions", "when", "patch", "tested", "with", "C0352536#ent", "<e2>", ")", "."], "h": {"id": "C0011616", "name": "C0011616#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0352536", "name": "C0352536#ent", "pos": [17, 18]}}
{"token": ["The", "KAP2", ",", "C1424717#ent", "<e1>", ",", "and", "KAP4", "genes", "encode", "proteins", "p18", "p17", ",", "and", "C0525037#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1424717", "name": "C1424717#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [15, 16]}}
{"token": ["Four", "patients", "died", "of", "cardiac", "problems", "C1541923#ent", "<e1>", "pericarditis", "with", "pericardial", "effusion", "C1384588#ent", "<e2>", "infection", "by", "Toxoplasma", "gondii"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1384588", "name": "C1384588#ent", "pos": [12, 13]}}
{"token": ["Latent", "infection", "be", "reactivated", "in", "the", "synovium", "of", "normal", "mice", "treated", "with", "C0699319#ent", "<e1>", "and", "this", "was", "associated", "with", "increased", "C0003864#ent", "<e2>"], "h": {"id": "C0699319", "name": "C0699319#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [20, 21]}}
{"token": ["1", "The", "pharmacokinetics", "and", "pharmacodynamics", "of", "C0029904#ent", "<e1>", ",", "digoxinn", "and", "beta-methyl", "digoxin", "C0025132#ent", "<e2>", ")", "have", "been", "investigated", "in", "a", "crossover", "study", "four", "normal", "healthy", "volunteers"], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025132", "name": "C0025132#ent", "pos": [13, 14]}}
{"token": ["In", "all", ",", "11", "patients", "(", "46", "%", ")", "had", "a", "significant", "C1366489#ent", "<e1>", "decline", "for", "a", "median", "C2926735#ent", "<e2>", "of", "11.4", "months", "."], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [18, 19]}}
{"token": ["Collectively", ",", "these", "results", "show", "that", "C0205812#ent", "<e1>", "activated", "the", "C1705527#ent", "<e2>", "cardiovascular", "cells", "through", "the", "sympathetic", "nervous", "system", "SNS", ")", ",", "via", "the", "alpha1-adrenergic", "receptor"], "h": {"id": "C0205812", "name": "C0205812#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705527", "name": "C1705527#ent", "pos": [10, 11]}}
{"token": ["OEA", "does", "not", "affect", "food", "intake", "injected", "into", "the", "brain", "ventricles", "and", "its", "C0003123#ent", "<e1>", "actions", "are", "prevented", "when", "C0151313#ent", "<e2>", "removed", "by", "treatment", "with", "capsaicin", "."], "h": {"id": "C0003123", "name": "C0003123#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [19, 20]}}
{"token": ["The", "hypothermic", "effect", "of", "d-amphetamine", "was", "investigated", "in", "rats", "in", "which", "vasoconstriction", "or", "vasodilation", "was", "induced", "by", "pharmacological", "agents", "aramine", "as", "C4255305#ent", "<e1>", "and", "neprasol", "as", "C0042402#ent", "<e2>", "."], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [26, 27]}}
{"token": ["Among", "prostanoids", ",", "Tromboxane", "(TX)A(2", ")", ",", "a", "potent", "platelet", "activator", "C4255305#ent", "<e1>", "and", "prostacyclin", "(", "PGI2", ")", ",", "a", "platelet", "inhibitor", "C0042402#ent", "<e2>", ",", "are", "the", "most", "important", "in", "controlling", "vascular", "homeostasis"], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [22, 23]}}
{"token": ["Primarily", ",", "L-dopa/benserazide", "and", "C0178601#ent", "<e1>", "used", ",", "but", "opioids", "and", "C0003286#ent", "<e2>", "are", "also", "successful", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [11, 12]}}
{"token": ["In", "previous", "case", "reports", "this", "C1848862#ent", "<e1>", "has", "been", "described", "in", "association", "with", "C0078981#ent", "<e2>", "abnormal", "collections", "of", "CSF", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0078981", "name": "C0078981#ent", "pos": [13, 14]}}
{"token": ["Metabolic", "bone", "disease", "including", "C0029453#ent", "<e1>", ",", "might", "contribute", "to", "the", "development", "of", "C0451840#ent", "<e2>", "chronic", "renal", "failure"], "h": {"id": "C0029453", "name": "C0029453#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0451840", "name": "C0451840#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "growth", "hormone", "prolactin-secreting", "pituitary", "tumors", "to", "show", "normal", "plasma", "catecholamine", "(", "especially", "C3887648#ent", "<e1>", ")", "responses", "to", "oral", "C0006230#ent", "<e2>", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [20, 21]}}
{"token": ["In", "isolated", "field", "stimulated", "rat", "vas", "deferens", "frequency-response", "curves", "were", "shifted", "to", "the", "right", "by", "C3887648#ent", "<e1>", ",", "dopamine", ",", "apomorphine", ",", "C0006230#ent", "<e2>", "and", "nomifensine", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [22, 23]}}
{"token": ["In", "conclusion", ",", "our", "results", "suggest", "that", "the", "balance", "between", "central", "noradrenaline", "5-hydroxytryptamine", "transmission", "important", "for", "the", "regulation", "by", "C1701455#ent", "<e1>", "of", "the", "C0242898#ent", "<e2>", "release", "in", "the", "cerebral", "cortex"], "h": {"id": "C1701455", "name": "C1701455#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [23, 24]}}
{"token": ["Whereas", "C0079471#ent", "<e1>", "and", "R-Ras", "were", "previously", "shown", "to", "affect", "T-cell", "adhesion", "C2712370#ent", "<e2>", "the", "affinity", "state", "of", "the", "integrin", "receptors", "no", "signaling", "molecule", "been", "identified", "for", "the", "second", "mechanism", "."], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "individual", "contributions", "of", "ERK", "and", "C1419744#ent", "<e1>", ",", "which", "can", "each", "phosphorylate", "the", "C3889380#ent", "<e2>", "regulatory", "domain", "to", "such", "stimulation", "are", "unknown", "."], "h": {"id": "C1419744", "name": "C1419744#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3889380", "name": "C3889380#ent", "pos": [16, 17]}}
{"token": ["The", "C1335866#ent", "<e1>", "and", "SSTR3", "specific", "C2987634#ent", "<e2>", "did", "not", "affect", "GH", "secretion", "under", "any", "condition", "tested", "."], "h": {"id": "C1335866", "name": "C1335866#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}}
{"token": ["Three", "components", "of", "the", "complement", "pathway", "C2", "Factor", "B", "and", "C4", "are", "coded", "for", "by", "four", "C1412938#ent", "<e1>", "Bf", ",", "C4A", ",", "and", "C1413000#ent", "<e2>", "in", "the", "class", "III", "region", "the", "major", "histocompatibility", "system", "man", "."], "h": {"id": "C1412938", "name": "C1412938#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413000", "name": "C1413000#ent", "pos": [23, 24]}}
{"token": ["All", "C3160718#ent", "<e1>", "programs", "are", "required", "to", "pass", "evaluations", "from", "the", "C3815274#ent", "<e2>", "before", "inception", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3815274", "name": "C3815274#ent", "pos": [11, 12]}}
{"token": ["This", "paralysis", "may", "be", "associated", "with", "C0025235#ent", "<e1>", "a", "triad", "of", "recurrent", "facial", "paralysis", "relapsing", "facial", "edema", "and", "associated", "C0040412#ent", "<e2>"], "h": {"id": "C0025235", "name": "C0025235#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0040412", "name": "C0040412#ent", "pos": [19, 20]}}
{"token": ["The", "C0025235#ent", "<e1>", "of", "a", "triad", "of", "recurrent", "lip", "and/or", "face", "swelling", "C0040412#ent", "<e2>", "and", "intermittent", "facial", "palsy"], "h": {"id": "C0025235", "name": "C0025235#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0040412", "name": "C0040412#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "C0162557#ent", "<e1>", "associated", "with", "undiagnosed", "maternal", "C1412107#ent", "<e2>", "MCAD", ")", "deficiency", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412107", "name": "C1412107#ent", "pos": [8, 9]}}
{"token": ["We", "report", "potential", "interference", "by", "C0700450#ent", "<e1>", "with", "our", "high", "performance", "liquid", "chromatography", "HPLC", ")", "procedure", "for", "assaying", "C0109354#ent", "<e2>", "chloramphenicol", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0109354", "name": "C0109354#ent", "pos": [18, 19]}}
{"token": ["However", ",", "the", "osmolarity", "of", "the", "brain", "tissue", "little", "and", "the", "mortality", "was", "decreased", "by", "C0024730#ent", "<e1>", "infusion", "to", "C0162557#ent", "<e2>", "rats", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [19, 20]}}
{"token": ["Sequence", "analysis", "an", "open", "reading", "frame", "593", "C3539946#ent", "<e1>", "an", "overall", "identity", "of", "63.6", "%", "with", "the", "C1425085#ent", "<e2>", "FRS1", ")", "of", "Saccharomyces", "cerevisiae"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1425085", "name": "C1425085#ent", "pos": [17, 18]}}
{"token": ["Two", "of", "these", "C0086376#ent", "<e1>", ",", "the", "receptor", "for", "activated", "C", "kinase", "1", "C1415151#ent", "<e2>", ")", "and", "the", "dynein", "intermediate", "chain", "co-immunoprecipitate", "with", "Gbetagamma", "using", "an", "anti-Gbeta", "antibody", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415151", "name": "C1415151#ent", "pos": [13, 14]}}
{"token": ["Further", ",", "we", "demonstrate", "that", "asc1Delta", "null", "strains", "have", "increased", "levels", "of", "specific", "C0086376#ent", "<e1>", "in", "vivo", "that", "this", "molecular", "phenotype", "complemented", "by", "either", "Asc1p", "or", "C1415151#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415151", "name": "C1415151#ent", "pos": [26, 27]}}
{"token": ["The", "influence", "on", "the", "actual", "CDDP", "dose", "was", "observed", "with", "or", "without", "use", "of", "C1705750#ent", "<e1>", "or", "by", "recommended", "dose", "CDDP", ",", "while", "no", "influence", "by", "C2936526#ent", "<e2>", "observed", "."], "h": {"id": "C1705750", "name": "C1705750#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2936526", "name": "C2936526#ent", "pos": [26, 27]}}
{"token": ["C0606005#ent", "<e1>", "active", "against", "Gram-positive", "and", "C0085423#ent", "<e2>"], "h": {"id": "C0606005", "name": "C0606005#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [6, 7]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "possible", "effect", "of", "C0271801#ent", "<e1>", "CH", ")", "on", "C1417244#ent", "<e2>", "."], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417244", "name": "C1417244#ent", "pos": [17, 18]}}
{"token": ["We", "describe", "and", "present", "a", "video", "of", "an", "C0221026#ent", "<e1>", "patient", "who", "developed", "a", "fatal", "dementing", ",", "C1839130#ent", "<e2>", "years", "into", "his", "immune", "disorder"], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1839130", "name": "C1839130#ent", "pos": [17, 18]}}
{"token": ["Coadministration", "of", "a", "steroid", "synthesis", "inhibitor", "trilostane", ")", "with", "C3537040#ent", "<e1>", "LH", "reduced", "(", "P", "<", "0.05", ")", "C1453171#ent", "<e2>", ",", "-8", ",", "and", "-9", "activity", "."], "h": {"id": "C3537040", "name": "C3537040#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1453171", "name": "C1453171#ent", "pos": [18, 19]}}
{"token": ["The", "present", "studies", "were", "designed", "to", "test", "the", "hypothesis", "that", "the", "inhibition", "of", "weight", "gain", "acute", "treatment", "C1097132#ent", "<e1>", "is", "due", "to", "a", "persistent", "C0003123#ent", "<e2>", "action", "of", "the", "compound", "."], "h": {"id": "C1097132", "name": "C1097132#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003123", "name": "C0003123#ent", "pos": [24, 25]}}
{"token": ["In", "isolated", "thyroid", "cells", "(", "0.1", "and", "10.0", "micrograms", "per", "milliliter", ")", ",", "norepinephrine", "and", "C0022245#ent", "<e1>", "consistently", "stimulated", "the", "accumulation", "and", "organic", "binding", "C0885449#ent", "<e2>", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0885449", "name": "C0885449#ent", "pos": [24, 25]}}
{"token": ["However", ",", "even", "higher", "levels", "of", "IL-6", "in", "the", "pleural", "fluid", "of", "C3277671#ent", "<e1>", "were", "found", "in", "patients", "with", "C0041326#ent", "<e2>"], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041326", "name": "C0041326#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "murine", "C1416655#ent", "<e1>", "that", "reduce", "the", "receptor", "tyrosine", "kinase", "activity", "C0268487#ent", "<e2>", "in", "the", "migration", "and", "proliferation", "of", "melanoblasts", ",", "hematopoietic", "stem", "cells", "and", "primordial", "germ", "cells"], "h": {"id": "C1416655", "name": "C1416655#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [12, 13]}}
{"token": ["Inhibitors", "of", "prostaglandin", "metabolism", "C1422342#ent", "<e1>", "to", "influence", "the", "stimulatory", "effect", "of", "C1539322#ent", "<e2>", "conditioned", "medium", "EC", "ACE", "."], "h": {"id": "C1422342", "name": "C1422342#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [12, 13]}}
{"token": ["It", "may", "also", "prove", "useful", "in", "the", "control", "of", "autonomic", "dysfunction", "as", "in", "C0270276#ent", "<e1>", "sialorrhea", ",", "and", "C0032781#ent", "<e2>", "."], "h": {"id": "C0270276", "name": "C0270276#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032781", "name": "C0032781#ent", "pos": [18, 19]}}
{"token": ["Some", "iNPH", "patients", "with", "C0152222#ent", "<e1>", "clinically", "might", "be", "misdiagnosed", "as", "C1420508#ent", "<e2>", "."], "h": {"id": "C0152222", "name": "C0152222#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420508", "name": "C1420508#ent", "pos": [11, 12]}}
{"token": ["The", "patient", "was", "a", "62-year-old", "man", "who", "complained", "of", "recurrent", "C0700200#ent", "<e1>", "episodes", ",", "dyspnoea", "often", "sudden", "in", "onset", ",", "C0004093#ent", "<e2>", "and", "major", "weight", "loss", "10", "kg", "in", "one", "month", ")", "."], "h": {"id": "C0700200", "name": "C0700200#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004093", "name": "C0004093#ent", "pos": [20, 21]}}
{"token": ["To", "clarify", "the", "situation", "in", "Bactrians", ",", "samples", "from", "suspected", "clinical", "cases", "be", "tested", "because", "other", "C0042769#ent", "<e1>", "not", "be", "distinguished", "from", "C3810599#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3810599", "name": "C3810599#ent", "pos": [22, 23]}}
{"token": ["This", "is", "the", "first", "report", "of", "an", "interaction", "between", "a", "C0178827#ent", "<e1>", "C1704840#ent", "<e2>", "and", "may", "implicate", "a", "role", "for", "host", "C1704840#ent", "<e2>", "in", "the", "potyviral", "infection", "process", "."], "h": {"id": "C0178827", "name": "C0178827#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704840", "name": "C1704840#ent", "pos": [12, 13]}}
{"token": ["Using", "a", "panel", "of", "oligonucleotide", "probes", "for", "various", "members", "of", "the", "rat", "kallikrein", "gene", "family", "we", "have", "shown", "that", "the", "C0966207#ent", "<e1>", "expressed", "appears", "to", "be", "C0618743#ent", "<e2>"], "h": {"id": "C0966207", "name": "C0966207#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [26, 27]}}
{"token": ["Downstream", "of", "C0966207#ent", "<e1>", ",", "where", "the", "genes", "encoding", "PSA", "and", "C0618743#ent", "<e2>", "are", "located", "in", "human", ",", "mouse", "carries", "the", "pseudogene", "PsimGK25", "."], "h": {"id": "C0966207", "name": "C0966207#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "using", "a", "panel", "of", "oligonucleotide", "probes", "for", "various", "members", "of", "the", "rat", "kallikrein-gene", "family", "we", "have", "shown", "that", "the", "C0966207#ent", "<e1>", "expressed", "appears", "to", "be", "expressed", "as", "C0618743#ent", "<e2>"], "h": {"id": "C0966207", "name": "C0966207#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [30, 31]}}
{"token": ["The", "proteins", "included", "myosin", "light", "chain", "1", "desmin", ",", "troponin", "T", "cofilin", "2", "F-actin", "capping", "protein", "\u03b2", "subunit", "ATP", "synthase", "C1311420#ent", "<e1>", "triosephosphate", "isomerase", "actin", "and", "its", "relevant", "peptides", ",", "C1418880#ent", "<e2>", "\u03b1-b", "crystalline", "heat", "shock", "protein", "27", "kDa"], "h": {"id": "C1311420", "name": "C1311420#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1418880", "name": "C1418880#ent", "pos": [30, 31]}}
{"token": ["C0032269#ent", "<e1>", "the", "most", "common", "invasive", "C0004623#ent", "<e2>", "children", "in", "the", "United", "States"], "h": {"id": "C0032269", "name": "C0032269#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [6, 7]}}
{"token": ["C0032269#ent", "<e1>", "for", "a", "significant", "proportion", "of", "C0004623#ent", "<e2>", "infants", "and", "children", "."], "h": {"id": "C0032269", "name": "C0032269#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}}
{"token": ["DYT1", "dystonia", "caused", "by", "a", "single", "GAG", "deletion", "in", "exon", "5", "C1540039#ent", "<e1>", ",", "the", "gene", "encoding", "C0665823#ent", "<e2>", ",", "a", "putative", "chaperone", "protein"], "h": {"id": "C1540039", "name": "C1540039#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0665823", "name": "C0665823#ent", "pos": [17, 18]}}
{"token": ["Staphylococcus", "aureus", "Cowan", "I", "C0220304#ent", "<e1>", "rapidly", "fixed", "in", "hot", "5", "%", "(", "w/v", ")", "C0040900#ent", "<e2>", "TCA", ")", "for", "6", "min", "in", "order", "to", "remove", "the", "negatively", "charged", "cell", "wall", "polymer", "teichoic", "acid", "."], "h": {"id": "C0220304", "name": "C0220304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040900", "name": "C0040900#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "case", "of", "a", "patient", "with", "C1842350#ent", "<e1>", "and", "previously", "resected", "colonic", "carcinoma", "was", "treated", "with", "chemoprophylaxis", "with", "long-term", "C0387583#ent", "<e2>", "(", "COX-2", ")", "inhibitors", "after", "declining", "colectomy", "."], "h": {"id": "C1842350", "name": "C1842350#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [21, 22]}}
{"token": ["We", "found", "a", "C0342883#ent", "<e1>", "by", "the", "C3149462#ent", "<e2>"], "h": {"id": "C0342883", "name": "C0342883#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C3149462", "name": "C3149462#ent", "pos": [7, 8]}}
{"token": ["Only", "two", "of", "the", "seven", "C0027803#ent", "<e1>", "preparations", "produced", "marked", "or", "moderate", "increases", "in", "inorganic", "pyrophosphatase", "C0028189#ent", "<e2>", "and", "cholinesterase", "."], "h": {"id": "C0027803", "name": "C0027803#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028189", "name": "C0028189#ent", "pos": [16, 17]}}
{"token": ["All", "are", "inhibitors", "of", "C1142644#ent", "<e1>", ",", "ranging", "from", "weak", "inhibition", "for", "C0286738#ent", "<e2>", "to", "very", "potent", "inhibition", "for", "ritonavir", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [4, 5]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0286738", "name": "C0286738#ent", "pos": [12, 13]}}
{"token": ["Ritonavir", "(", "RIT", ")", "is", "a", "potent", "inhibitor", "of", "C1142644#ent", "<e1>", "and", "inhibits", "C0286738#ent", "<e2>", "(", "SQV", ")", "metabolism", "in", "healthy", "volunteers"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [9, 10]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0286738", "name": "C0286738#ent", "pos": [13, 14]}}
{"token": ["In", "the", "clinical", "situation", "this", "may", "be", "of", "particular", "importance", "during", "both", "C0028961#ent", "<e1>", "and", "the", "recovery", "from", "C0022672#ent", "<e2>"], "h": {"id": "C0028961", "name": "C0028961#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022672", "name": "C0022672#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "through", "the", "repetitive", "release", "of", "intracellular", "Ca2", "+", ",", "C0082011#ent", "<e1>", "enhanced", "phosphotransferase", "activities", "Ca2+/calmodulin-dependent", "protein", "kinase", "type", "IV", "CaMK", "IV", ",", "which", "were", "inhibited", "by", "C0216938#ent", "<e2>", "."], "h": {"id": "C0082011", "name": "C0082011#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0216938", "name": "C0216938#ent", "pos": [29, 30]}}
{"token": ["Because", "inactivation", "of", "C0525037#ent", "<e1>", "which", "is", "a", "C1428945#ent", "<e2>", "is", "thought", "to", "have", "similar", "oncogenic", "effects", "CD1", "gene", "amplification", "DPCR", "was", "used", "to", "examine", "whether", "p16", "homozygous", "deletion", "occurs", "in", "esophageal", "carcinosarcoma"], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428945", "name": "C1428945#ent", "pos": [8, 9]}}
{"token": ["The", "function", "of", "C0525037#ent", "<e1>", "as", "a", "C1428945#ent", "<e2>", "examined", "by", "investigating", "its", "ability", "to", "inhibit", "the", "growth", "of", "cancer", "cell", "lines", "in", "vitro", "tumor", "formation", "in", "vivo"], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428945", "name": "C1428945#ent", "pos": [7, 8]}}
{"token": ["Fifty-seven", "patients", "with", "advanced", "malignant", "tumours", "treated", "with", "ifosfamide", "(", "C0733930#ent", "<e1>", ")", "and", "mesna", "(", "C0678115#ent", "<e2>", ")", "in", "our", "department", "from", "November", "1979", "to", "December", "1984", "."], "h": {"id": "C0733930", "name": "C0733930#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0678115", "name": "C0678115#ent", "pos": [16, 17]}}
{"token": ["In", "these", "studies", "we", "find", "that", "coexpression", "of", "C1417089#ent", "<e1>", "with", "E2F-1", "results", "in", "degradation", "of", "the", "C2981746#ent", "<e2>"], "h": {"id": "C1417089", "name": "C1417089#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2981746", "name": "C2981746#ent", "pos": [17, 18]}}
{"token": ["Contacts", "made", "by", "serine", "are", "identical", "and", "crucial", "for", "all", "C0030956#ent", "<e1>", ",", "and", "Trp165", "in", "the", "peptide-binding", "pocket", "of", "C1421408#ent", "<e2>", "is", "also", "crucial", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421408", "name": "C1421408#ent", "pos": [20, 21]}}
{"token": ["No", "statistically", "significant", "in", "C3887624#ent", "<e1>", "demonstrated", "between", "the", "groups", "of", "patients", "with", "C0003873#ent", "<e2>", "seronegative", "spondylarthropathy", "microcrystalline", "arthritis", "or", "osteoarthritis", "."], "h": {"id": "C3887624", "name": "C3887624#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}}
{"token": ["The", "binding", "in", "vitro", "the", "sodium", "salts", "cholic", "acid", "chenodeoxycholic", "acid", "deoxycholic", "acid", "taurocholic", "acid", "taurochenodeoxycholic", "acid", "taurodeoxycholic", "acid", "glycocholic", "acid", "glycochenodeoxycholic", "acid", "and", "C0017903#ent", "<e1>", "alfalfa", ",", "bran", ",", "cellulose", ",", "lignin", ",", "and", "C0008402#ent", "<e2>", "was", "measured", "."], "h": {"id": "C0017903", "name": "C0017903#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [35, 36]}}
{"token": ["Down", "syndrome", "C0012772#ent", "<e1>", ")", "is", "the", "most", "common", "C1516876#ent", "<e2>", "defined", "cause", "of", "intellectual", "disabilities"], "h": {"id": "C0012772", "name": "C0012772#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [9, 10]}}
{"token": ["The", "liver/body", "weight", "(", "LW/BW", ")", "ratio", "also", "decreased", "in", "the", "C3810569#ent", "<e1>", "shunt", "both", "with", "and", "even", "without", "70", "%", "C1134446#ent", "<e2>", "."], "h": {"id": "C3810569", "name": "C3810569#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [21, 22]}}
{"token": ["Limited", "data", "that", "the", "new", "C3540047#ent", "<e1>", "as", "a", "class", "may", "lead", "to", "better", "outcomes", "in", "C0694549#ent", "<e2>", "acute", "exacerbations", "chronic", "bronchitis", "comparators", "."], "h": {"id": "C3540047", "name": "C3540047#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0694549", "name": "C0694549#ent", "pos": [16, 17]}}
{"token": ["Macrolides", "and", "C3540047#ent", "<e1>", "are", "frequently", "used", "for", "the", "empiric", "treatment", "C0694549#ent", "<e2>", "CAP", ")", "."], "h": {"id": "C3540047", "name": "C3540047#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0694549", "name": "C0694549#ent", "pos": [11, 12]}}
{"token": ["We", "therefore", "investigated", "whether", "A2", "agonists", "inhibit", "C1424852#ent", "<e1>", "inputs", "into", "second-order", "neurons", "and", "whether", "selective", "antagonists", "to", "C1419351#ent", "<e2>", ",", "A2A", ",", "or", "A3", "receptors", "prevent", "Ca2", "+", "influx", "through", "rod", "ICa", "."], "h": {"id": "C1424852", "name": "C1424852#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419351", "name": "C1419351#ent", "pos": [18, 19]}}
{"token": ["In", "hepatocytes", "from", "C0342895#ent", "<e1>", "rats", ",", "however", ",", "the", "rate", "of", "C1418609#ent", "<e2>", "nearly", "one-half", "that", "of", "gluconeogenesis", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418609", "name": "C1418609#ent", "pos": [12, 13]}}
{"token": ["Individuals", "with", "C3831153#ent", "<e1>", "exhibit", "concentrations", "of", "carbonic", "anhydrase", "I", "C0064494#ent", "<e2>", ")", "in", "red", "blood", "cells", "reflect", "the", "integrated", "serum", "thyroid", "hormone", "concentration", "over", "the", "preceding", "few", "months", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0064494", "name": "C0064494#ent", "pos": [10, 11]}}
{"token": ["Phylogenetic", "analysis", "the", "CYP4", "gene", "families", "that", "C0051169#ent", "<e1>", "and", "CYP4B", "are", "more", "closely", "related", "than", "C1413889#ent", "<e2>", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413889", "name": "C1413889#ent", "pos": [16, 17]}}
{"token": ["Interactions", "of", "food", "proteins", "beta-lactoglobulin", "(", "C1417453#ent", "<e1>", ")", ",", "bovine", "serum", "albumin", "BSA", ")", "und", "ovalbumin", "(OA)--with", "C3541860#ent", "<e2>", "and", "effect", "of", "thermal", "denaturation", "of", "the", "proteins", "on", "vanillin", "binding", "studies", "by", "US-VIS", "spectrophotometry"], "h": {"id": "C1417453", "name": "C1417453#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541860", "name": "C3541860#ent", "pos": [18, 19]}}
{"token": ["Point", "mutations", "the", "gene", "encoding", "Cu", ",", "C0038838#ent", "<e1>", "SOD1", ")", "are", "associated", "with", "autosomal", "dominant", "C0002736#ent", "<e2>", "FALS", ")", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [16, 17]}}
{"token": ["The", "primary", "mechanism", "which", "mutations", "in", "Cu", ",", "C0038838#ent", "<e1>", "SOD1", ")", "contribute", "to", "progressive", "motor", "neuron", "loss", "C0002736#ent", "<e2>", "FALS", ")", "remains", "unknown", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [18, 19]}}
{"token": ["The", "results", "of", "this", "study", "suggest", "that", "Sudan", "III-induced", "prevention", "of", "in", "vivo", "mutagenesis", "is", "due", "to", "the", "induction", "of", "both", "C0796517#ent", "<e1>", "1A1", "and", "detoxifying", "phase", "II", "C3541394#ent", "<e2>", "."], "h": {"id": "C0796517", "name": "C0796517#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [28, 29]}}
{"token": ["The", "xenobiotic-metabolising", "machinery", "contains", "two", "main", "types", "of", "C3541394#ent", "<e1>", ":", "the", "phase-I", "cytochromes", "P-450", "C0796517#ent", "<e2>", ")", "mediating", "oxidative", "metabolism", "and", "phase-II", "conjugating", "C3541394#ent", "<e1>", "."], "h": {"id": "C0796517", "name": "C0796517#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [8, 9]}}
{"token": ["These", "C0030193#ent", "<e1>", "were", "treated", "with", "NSAIDs", "or", "C0030873#ent", "<e2>", "before", "the", "consultation", "with", "inadequate", "relief", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0030873", "name": "C0030873#ent", "pos": [8, 9]}}
{"token": ["We", "found", "that", "HARP", "is", "an", "ATP-dependent", "annealing", "helicase", "rewinds", "single-stranded", "DNA", "bubbles", "are", "stably", "bound", "by", "replication", "protein", "A.", "related", "C0001473#ent", "<e1>", ",", "including", "the", "DNA", "translocase", "Rad54", ",", "did", "not", "exhibit", "C2975114#ent", "<e2>", "helicase", "activity", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [21, 22]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2975114", "name": "C2975114#ent", "pos": [33, 34]}}
{"token": ["According", "to", "the", "binding-zipper", "model", ",", "the", "RecA", "class", "of", "C0001473#ent", "<e1>", "chemical", "energy", "mechanical", "force", "the", "progressive", "C2975114#ent", "<e2>", "of", "hydrogen", "bonds", "the", "nucleotide", "and", "the", "catalytic", "pocket"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2975114", "name": "C2975114#ent", "pos": [18, 19]}}
{"token": ["C1420563#ent", "<e1>", "acts", "as", "an", "antagonist", "to", "C1420314#ent", "<e2>", "in", "vitro", "but", "its", "in", "vivo", "function", "has", "reached", "no", "consensus", "conclusions", "."], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [7, 8]}}
{"token": ["Cell", "adhesion", "extracellular", "matrix", "stimulation", "of", "an", "eicosanoid", "signaling", "pathway", "the", "metabolism", "of", "arachidonate", "by", "C1412361#ent", "<e1>", "to", "leukotrienes", "and", "cyclooxygenase-1/2", "to", "C0356622#ent", "<e2>", ",", "as", "well", "as", "activation", "of", "the", "small", "GTPase", "signaling", "pathway", "Cdc42", "and", "Rho", "."], "h": {"id": "C1412361", "name": "C1412361#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [22, 23]}}
{"token": ["C1415382#ent", "<e1>", "hydrolyzes", "the", "C1335079#ent", "<e2>", "SET", "in", "its", "recombinant", "and", "native", "forms", "or", "in", "intact", "cells", "."], "h": {"id": "C1415382", "name": "C1415382#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335079", "name": "C1335079#ent", "pos": [4, 5]}}
{"token": ["Caffeine", "(", "1,3,7-trimethylxanthine", ")", ",", "theobromine", "(", "C0039763#ent", "<e1>", ")", "and", "theophylline", "(", "C0039771#ent", "<e2>", ")", "are", "the", "most", "important", "naturally", "occurring", "methylxanthines", "."], "h": {"id": "C0039763", "name": "C0039763#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039771", "name": "C0039771#ent", "pos": [13, 14]}}
{"token": ["The", "opposite", "effect", "(", "contralateral", "rotations", "was", "observed", "with", "adenosine", "receptor", "antagonists", "A2", "antagonist", "C0039763#ent", "<e1>", ",", "DMPX", ",", "10", "micrograms", ";", "A1", "antagonist", "C0039771#ent", "<e2>", ",", "CPT", ",", "2.5", "micrograms", ")", "."], "h": {"id": "C0039763", "name": "C0039763#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039771", "name": "C0039771#ent", "pos": [24, 25]}}
{"token": ["The", "effects", "of", "caffeine", "(", "C0039763#ent", "<e1>", ")", "and", "theophylline", "(", "C0039771#ent", "<e2>", ")", "on", "caudate", "dopamine", "release", "were", "examined", "in", "urethane", "anesthetized", "freely", "moving", "rats", "using", "in", "vivo", "electrochemistry", "."], "h": {"id": "C0039763", "name": "C0039763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039771", "name": "C0039771#ent", "pos": [11, 12]}}
{"token": ["In", "the", "experiment", ",", "C0772394#ent", "<e1>", "rHV2", ")", "was", "chosen", "as", "a", "large", "hydrophilic", "molecular", "model", "C1254351#ent", "<e2>", "."], "h": {"id": "C0772394", "name": "C0772394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}}
{"token": ["We", "report", "that", "C1425513#ent", "<e1>", ",", "Ctf8", ",", "and", "Dcc1", ",", "the", "C0599220#ent", "<e2>", "of", "a", "Replication", "Factor", "C", "(RFC)-like", "complex", ",", "are", "essential", "for", "the", "perinuclear", "positioning", "telomeres", "."], "h": {"id": "C1425513", "name": "C1425513#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}}
{"token": ["During", "the", "last", "10", "years", "new", "approaches", "for", "rapid", "opioid", "detoxification", "have", "included", "drug", "combinations", "as", "C0009014#ent", "<e1>", "and", "naltrexone", "to", "speed", "and", "ease", "the", "transition", "from", "C1883695#ent", "<e2>", "antagonist", "maintenance", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1883695", "name": "C1883695#ent", "pos": [27, 28]}}
{"token": ["Noncoding", "sequences", "300", "base", "pairs", "5", "'", "and", "1000", "base", "pairs", "3", "'", "to", "the", "sapB", "and", "C1418975#ent", "<e1>", "C0079941#ent", "<e2>", ",", "including", "the", "C1418975#ent", "<e1>", "promoter", "and", "transcriptional", "terminator", "sequences", "were", "essentially", "identical", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418975", "name": "C1418975#ent", "pos": [17, 18]}}
{"token": ["The", "use", "of", "highly", "effective", "reversible", "C0009905#ent", "<e1>", "is", "important", "for", "women", "with", "health", "issues", "yet", "sometimes", "those", "same", "C0679247#ent", "<e2>", "make", "the", "C0009905#ent", "<e1>", "themselves", "less", "effective", "or", "less", "safe", "."], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0009905", "name": "C0009905#ent", "pos": [6, 7]}}
{"token": ["C0012888#ent", "<e1>", "ATPase", "activities", "present", "in", "the", "final", "preparation", "of", "C1427831#ent", "<e2>"], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427831", "name": "C1427831#ent", "pos": [10, 11]}}
{"token": ["The", "cholinergic", "antagonists", "mecamylamine", "and", "atropine", ",", "the", "C0242702#ent", "<e1>", "haloperidol", "and", "sulpiride", ",", "and", "the", "C0242909#ent", "<e2>", "inhibited", "the", "nicotine-induced", "increase", "of", "extracellular", "dopamine", "in", "the", "striatum", "."], "h": {"id": "C0242702", "name": "C0242702#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242909", "name": "C0242909#ent", "pos": [16, 17]}}
{"token": ["The", "inhibitory", "effects", "of", "C0056170#ent", "<e1>", "were", "overcome", "by", "the", "addition", "of", "mevalonate", ",", "farnesyl", "pyrophosphate", "C0061230#ent", "<e2>"], "h": {"id": "C0056170", "name": "C0056170#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0061230", "name": "C0061230#ent", "pos": [16, 17]}}
{"token": ["Intrarenal", "resistance", "and", "release", "of", "C0796254#ent", "<e1>", "by", "both", "the", "C0020295#ent", "<e2>", "(", "HNK", ")", "and", "contralateral", "kidney", "CLK", ")", "were", "quantified", "."], "h": {"id": "C0796254", "name": "C0796254#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020295", "name": "C0020295#ent", "pos": [10, 11]}}
{"token": ["In", "a", "dose-dependent", "manner", ",", "C0023660#ent", "<e1>", "significantly", "attenuated", "the", "LPS-induced", "upregulation", "of", "C0669372#ent", "<e2>", "and", "CAT-2", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [13, 14]}}
{"token": ["The", "GST-tagged", "C1537596#ent", "<e1>", "was", "also", "able", "to", "pull", "down", "P-cadherin", "together", "with", "C1332803#ent", "<e2>", "from", "human", "kidney", "glomerular", "lysates"], "h": {"id": "C1537596", "name": "C1537596#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "the", "presynaptic", "inhibitory", "action", "of", "group-II", "metabotropic", "glutamate", "receptors", "C1280469#ent", "<e1>", "fibre-CA3", "synapses", "could", "be", "negatively", "regulated", "by", "protein", "kinase", "C-", "cyclic", "C1514550#ent", "<e2>", "mechanisms", "."], "h": {"id": "C1280469", "name": "C1280469#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [26, 27]}}
{"token": ["Against", "the", "anaerobic", "Gram-negative", "organisms", "C0663241#ent", "<e1>", "was", "more", "potent", "than", "C0663242#ent", "<e2>", ",", "especially", "for", "Bacteroides", "species"], "h": {"id": "C0663241", "name": "C0663241#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0663242", "name": "C0663242#ent", "pos": [11, 12]}}
{"token": ["C0663241#ent", "<e1>", "was", "more", "active", "than", "C0663242#ent", "<e2>", "against", "the", "strains", "tested", ";", "premafloxacin", "was", "the", "most", "active", "comparator", "antibiotic", "."], "h": {"id": "C0663241", "name": "C0663241#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0663242", "name": "C0663242#ent", "pos": [6, 7]}}
{"token": ["Important", "representatives", "of", "this", "class", "include", "the", "morpholine", "derivative", "C0663241#ent", "<e1>", "which", "is", "currently", "in", "phase", "III", "clinical", "trials", "and", "the", "piperazine", "derivative", "C0663242#ent", "<e2>"], "h": {"id": "C0663241", "name": "C0663241#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0663242", "name": "C0663242#ent", "pos": [23, 24]}}
{"token": ["Of", "this", "subset", "of", "C1414316#ent", "<e1>", "only", "the", "expression", "of", "C1705288#ent", "<e2>", "and", "DNA", "polymerase", "alpha", "significantly", "repressed", "."], "h": {"id": "C1414316", "name": "C1414316#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705288", "name": "C1705288#ent", "pos": [10, 11]}}
{"token": ["This", "dual", "C1417585#ent", "<e1>", "binds", "DNA", "with", "its", "C-terminal", "zinc", "finger", "(", "C1421688#ent", "<e2>", ")", "and", "stabilizes", "this", "binding", "with", "its", "N-terminal", "zinc", "finger", "ZnF1", ")", "."], "h": {"id": "C1417585", "name": "C1417585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421688", "name": "C1421688#ent", "pos": [12, 13]}}
{"token": ["As", "a", "result", "of", "inhibition", "of", "plasma", "cholinesterase", "increased", "sensitivity", "to", "drugs", "hydrolyzed", "by", "this", "C0027203#ent", "<e1>", "can", "occur", ",", "e.g.", "C0038627#ent", "<e2>", "and", "mivacurium", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0038627", "name": "C0038627#ent", "pos": [21, 22]}}
{"token": ["We", "describe", "a", "71-year-old", "diabetic", "man", "with", "C2316810#ent", "<e1>", "presented", "with", "C0007462#ent", "<e2>", "the", "left", "hand", "month", "after", "construction", "of", "a", "PTFE", "(", "polytetrafluroethylene", ")", "arteriovenous", "graft"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007462", "name": "C0007462#ent", "pos": [11, 12]}}
{"token": ["The", "C1457887#ent", "<e1>", "examined", "in", "91", "hospitalized", "patients", "with", "osteoarthrosis", "of", "the", "C1337104#ent", "<e2>", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1337104", "name": "C1337104#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "examined", "the", "role", "of", "C0623362#ent", "<e1>", "in", "cytoskeletal", "dynamics", "a", "phosphorylation-dependent", "inhibitor", "protein", "for", "C0623362#ent", "<e1>", ",", "called", "C1423014#ent", "<e1>", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423014", "name": "C1423014#ent", "pos": [20, 21]}}
{"token": ["mRNA", "expression", "of", "forkhead", "box", "a2", "C1415627#ent", "<e1>", ")", ",", "the", "binding", "site", "which", "was", "located", "between", "C2740858#ent", "<e2>", "-1382", "and", "-780", ",", "was", "found", "to", "decrease", "on", "treatment", "with", "insulin", "."], "h": {"id": "C1415627", "name": "C1415627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2740858", "name": "C2740858#ent", "pos": [17, 18]}}
{"token": ["However", ",", "C3891562#ent", "<e1>", "was", "the", "only", "C1335285#ent", "<e2>", "isoform", "that", "provided", "a", "costimulatory", "signal", "a", "solid-phase", "antibody-induced", "cellular", "proliferation", "assay", "."], "h": {"id": "C3891562", "name": "C3891562#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335285", "name": "C1335285#ent", "pos": [7, 8]}}
{"token": ["We", "studied", "the", "effects", "of", "oral", "beta2", "selective", "bronchodilator", ",", "C0071129#ent", "<e1>", ",", "in", "12", "male", "C0004096#ent", "<e2>", "patients", "over", "periods", "ranging", "from", "6", "to", "23", "months", "(", "mean", ",", "13.8", ")", "."], "h": {"id": "C0071129", "name": "C0071129#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["NGFI-B", "did", "not", "colocalize", "with", "striatal", "aspiny", "interneurons", "expressing", "C0008407#ent", "<e1>", "mRNA", "or", "those", "containing", "the", "C1413053#ent", "<e2>", "parvalbumin", "."], "h": {"id": "C0008407", "name": "C0008407#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413053", "name": "C1413053#ent", "pos": [16, 17]}}
{"token": ["to", "cause", "disseminated", "disease", "to", "develop", "resistance", "to", "multiple", "C1136254#ent", "<e1>", "in", "the", "initial", "treatment", "of", "serious", "C0028242#ent", "<e2>"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028242", "name": "C0028242#ent", "pos": [17, 18]}}
{"token": ["These", "include", "the", "t(11;17)(q23;q21", ")", "that", "produces", "the", "PLZF-RAR", "fusion", "t(5;17)(q35;q21", ")", "that", "forms", "NPM-RAR", ",", "t(11;17)(q13;q21", ")", "that", "generates", "C1834115#ent", "<e1>", ",", "and", "der(17", ")", "that", "creates", "C3274858#ent", "<e2>", "."], "h": {"id": "C1834115", "name": "C1834115#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3274858", "name": "C3274858#ent", "pos": [28, 29]}}
{"token": ["Following", "surgery", "for", "a", "chronic", "subdural", "haematoma", "a", "74-year-old", "patient", "received", "C0244656#ent", "<e1>", "as", "prophylaxis", "for", "C0014547#ent", "<e2>", "."], "h": {"id": "C0244656", "name": "C0244656#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [16, 17]}}
{"token": ["To", "further", "analyze", "the", "structural", "and", "functional", "similarity", "between", "C1335817#ent", "<e1>", "and", "mammalian", "C1335078#ent", "<e2>", ",", "we", "cloned", "and", "sequenced", "nucleoporin", "p62", "a", "HeLa", "cDNA", "library"], "h": {"id": "C1335817", "name": "C1335817#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335078", "name": "C1335078#ent", "pos": [13, 14]}}
{"token": ["C1335817#ent", "<e1>", "is", "a", "nuclear", "pore", "protein", "C1335078#ent", "<e2>", ")", "essential", "for", "cell", "growth"], "h": {"id": "C1335817", "name": "C1335817#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335078", "name": "C1335078#ent", "pos": [7, 8]}}
{"token": ["Glutamic", "acid", "laboratory", "and", "clinical", "investigations", "the", "early", "1960s", "was", "found", "to", "antagonize", "C0042671#ent", "<e1>", ",", "another", "clinically", "useful", "C0042672#ent", "<e2>"], "h": {"id": "C0042671", "name": "C0042671#ent", "pos": [13, 14]}, "relation": "has_chemical_structure", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [19, 20]}}
{"token": ["The", "C1420652#ent", "<e1>", "and", "Tct", "sites", "of", "C2984593#ent", "<e2>", "were", "mapped", "by", "S1", "nuclease", "analyses", "to", "nts", "13,637", "and", "11,408", ",", "respectively", "."], "h": {"id": "C1420652", "name": "C1420652#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2984593", "name": "C2984593#ent", "pos": [7, 8]}}
{"token": ["Microsomal", "epoxide", "hydrolase", "inhibited", "by", "C0040903#ent", "<e1>", "10(-4", ")", "M", ")", "and", "C0056764#ent", "<e2>", "10(-3", ")", "M", ")", ",", "and", "cytosolic", "epoxide", "hydrolase", "4-fluorochalcone", "oxide", "5", "x", "10(-4", ")", "M", ")", "."], "h": {"id": "C0040903", "name": "C0040903#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0056764", "name": "C0056764#ent", "pos": [12, 13]}}
{"token": ["CTLA-4", "is", "a", "predicted", "membrane", "receptor", "cytotoxic", "T", "cells", "is", "homologous", "to", "C1332709#ent", "<e1>", "and", "whose", "gene", "maps", "the", "same", "chromosomal", "band", "the", "C0079429#ent", "<e2>", "for", "C1332709#ent", "<e1>", "."], "h": {"id": "C1332709", "name": "C1332709#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [23, 24]}}
{"token": ["It", "is", "suggested", "that", "X537A", "causes", "an", "exchange", "of", "intravesicular", "C3536742#ent", "<e1>", "with", "a", "cytoplasmic", "cation", "perhaps", "C0071766#ent", "<e2>", "H(+)", "across", "the", "storage", "vesicle", "membrane", "."], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0071766", "name": "C0071766#ent", "pos": [17, 18]}}
{"token": ["DAMGO", "reversibly", "inhibited", "the", "[Ca(2+)](i", ")", "increase", "and", "C3536742#ent", "<e1>", "release", "induced", "by", "high", "C0071766#ent", "<e2>"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0071766", "name": "C0071766#ent", "pos": [14, 15]}}
{"token": ["C3812730#ent", "<e1>", "immunoprecipitations", "were", "positive", "for", "C0073186#ent", "<e2>", "mRNA", "indicating", "an", "in", "vivo", "association", ",", "and", "Western", "blot", "analysis", "immunofluorescence", "demonstrated", "that", "C3812730#ent", "<e1>", "rapidly", "partitions", "from", "the", "nucleus", "to", "the", "cytoplasm", "after", "UVL", "."], "h": {"id": "C3812730", "name": "C3812730#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0073186", "name": "C0073186#ent", "pos": [6, 7]}}
{"token": ["Two", "angiotensin", "converting", "enzyme", "(ACE)", "inhibitors", "trandolapril", "and", "C0014025#ent", "<e1>", ",", "were", "compared", "for", "their", "effects", "on", "rat", "food-pad", "C0013604#ent", "<e2>", "induced", "by", "carrageenin", ",", "bradykinin", ",", "dextran", "and", "platelet", "activating", "factor", "PAF", ")", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [19, 20]}}
{"token": ["Treatment", "of", "amoebae", "with", "C3541394#ent", "<e1>", "or", "metabolic", "inhibitors", "to", "incubation", "in", "C0796085#ent", "<e2>", "was", "performed", "to", "investigate", "the", "mechanism", "of", "complement", "resistance"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0796085", "name": "C0796085#ent", "pos": [12, 13]}}
{"token": ["Our", "data", "demonstrated", "that", "ketotifen", "was", "as", "effective", "as", "C0354872#ent", "<e1>", "in", "the", "treatment", "of", "C0042109#ent", "<e2>", "Thai", "children", "."], "h": {"id": "C0354872", "name": "C0354872#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [15, 16]}}
{"token": ["We", "determined", "whether", "C1826724#ent", "<e1>", "was", "involved", "in", "lytic", "cycle", "induction", "C1333891#ent", "<e2>", "HDAC", ")", "inhibitors", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [11, 12]}}
{"token": ["Sera", "from", "patients", "with", "C0015652#ent", "<e1>", ",", "taeniasis", ",", "schistosomiasis", ",", "C0030100#ent", "<e2>", ",", "trichinellosis", "and", "ancyclostomiasis", "gave", "counts", "similar", "to", "cord", "serum", "controls", "."], "h": {"id": "C0015652", "name": "C0015652#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030100", "name": "C0030100#ent", "pos": [11, 12]}}
{"token": ["Activation", "is", "considerably", "accelerated", "by", "catalytic", "amounts", "C0960371#ent", "<e1>", "or", "highly", "purified", "C0001214#ent", "<e2>", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001214", "name": "C0001214#ent", "pos": [12, 13]}}
{"token": ["Although", "patient", "numbers", "were", "small", ",", "these", "results", "indicate", "that", "the", "addition", "of", "intrarenal", "gallopamil", "intravenous", "C0016860#ent", "<e1>", "treatment", "enhances", "the", "recovery", "of", "renal", "function", "C0022660#ent", "<e2>"], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [25, 26]}}
{"token": ["The", "effect", "of", "C0016860#ent", "<e1>", "on", "the", "development", "of", "the", "C0022660#ent", "<e2>", "the", "dog", "was", "studied", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [10, 11]}}
{"token": ["One", "sample", "with", "a", "gain", "of", "chromosome", "12", "a", "very", "strong", "expression", "of", "MDM2", ",", "strong", "expression", "of", "C0246957#ent", "<e1>", ",", "and", "amplification", "of", "C1426104#ent", "<e2>", "."], "h": {"id": "C0246957", "name": "C0246957#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1426104", "name": "C1426104#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "clones", "were", "found", "corresponding", "to", "the", "C0243459#ent", "<e1>", "to", "the", "C3536868#ent", "<e2>", "GAPDH", ")", "."], "h": {"id": "C0243459", "name": "C0243459#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536868", "name": "C3536868#ent", "pos": [13, 14]}}
{"token": ["Delayed", "C0017168#ent", "<e1>", "has", "been", "attributed", "to", "autonomic", "neuropathy", "established", "C0011849#ent", "<e2>", "but", "rapid", "C0017168#ent", "<e1>", "was", "demonstrated", "in", "early", "Type", "2", "diabetes"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [1, 2]}}
{"token": ["This", "report", "describes", "a", "60-year-old", "female", "who", "was", "diagnosed", "with", "C0282207#ent", "<e1>", "hypothyroidism", "after", "presenting", "with", "chronic", "diarrhea", "alopecia", ",", "C0000737#ent", "<e2>", "generalized", "gastrointestinal", "polyposis", ",", "hyperpigmentation", ",", "and", "nail", "dystrophy"], "h": {"id": "C0282207", "name": "C0282207#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [20, 21]}}
{"token": ["This", "article", "summarizes", "the", "existing", "data", "on", "the", "role", "of", "T-cells", "in", "the", "pathogenesis", "of", "three", "types", "of", "C0014060#ent", "<e1>", "RE", ",", "paraneoplastic", "encephalomyelitis", "and", "C0243010#ent", "<e2>"], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0243010", "name": "C0243010#ent", "pos": [25, 26]}}
{"token": ["The", "subjects", "of", "this", "paper", "are", "mainly", "the", "C0014060#ent", "<e1>", "of", "viral", "origin", "in", "addition", "3", "types", "of", "C0243010#ent", "<e2>", "practical", "importance", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243010", "name": "C0243010#ent", "pos": [18, 19]}}
{"token": ["The", "mechanism", "by", "which", "p50", "is", "generated", "in", "vivo", "and", "the", "C1539479#ent", "<e1>", "of", "the", "C-terminal", "region", "C2348445#ent", "<e2>", "have", "not", "been", "established", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2348445", "name": "C2348445#ent", "pos": [17, 18]}}
{"token": ["The", "three", "cardiovascular", "agents", ":", "two", "C0006684#ent", "<e1>", "bepridil", "and", "C0763450#ent", "<e2>", ",", "and", "one", "thioindolaminidine", "antianginal", "agent", ",", "RWJ-34130", "."], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0763450", "name": "C0763450#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "a", "correlation", "was", "found", "to", "exist", "between", "C3539529#ent", "<e1>", "expression", "and", "regulation", "in", "response", "to", "C0812325#ent", "<e2>", "and", "malignant", "potential", "."], "h": {"id": "C3539529", "name": "C3539529#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [18, 19]}}
{"token": ["The", "ability", "of", "efavirenz", "to", "inactivate", "both", "enzymes", "was", "investigated", "using", "cyclophosphamide", "and", "C0085208#ent", "<e1>", ",", "two", "structurally", "unrelated", "substrates", "of", "C0534137#ent", "<e2>", "as", "probes", "."], "h": {"id": "C0085208", "name": "C0085208#ent", "pos": [13, 14]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [21, 22]}}
{"token": ["In", "the", "absence", "of", "C1420144#ent", "<e1>", ",", "hippocampal", "neurons", "exhibited", "stunted", "neurite", "outgrowth", "less", "C1415287#ent", "<e2>", "clustering", ",", "and", "reduced", "spontaneous", "neuronal", "activity"], "h": {"id": "C1420144", "name": "C1420144#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415287", "name": "C1415287#ent", "pos": [14, 15]}}
{"token": ["The", "C0006266#ent", "<e1>", "responded", "slowly", "to", "salbutamol", "and", "C0002575#ent", "<e2>", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [8, 9]}}
{"token": ["There", "is", "also", "an", "increased", "risk", "for", "bronchospasm", "in", "patients", "with", "a", "history", "of", "asthma", ";", "C0006266#ent", "<e1>", "be", "relieved", "immediately", "by", "administration", "of", "C0002575#ent", "<e2>", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "suggest", "that", "C0210108#ent", "<e1>", "regulates", "SMC", "migration", "in", "intimal", "thickening", "atheroma", "formation", "and", "that", "C1259877#ent", "<e2>", "play", "an", "important", "role", "in", "the", "inhibitory", "mechanism", "of", "C0210108#ent", "<e1>", "."], "h": {"id": "C0210108", "name": "C0210108#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [16, 17]}}
{"token": ["C0796467#ent", "<e1>", "CA4P", ")", "and", "its", "structural", "analog", "C2827544#ent", "<e2>", "CA1P", ")", ",", "are", "soluble", "prodrugs", "capable", "of", "interacting", "with", "tubulin", "and", "causing", "rapid", "vascular", "shutdown", "tumors", "."], "h": {"id": "C0796467", "name": "C0796467#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2827544", "name": "C2827544#ent", "pos": [8, 9]}}
{"token": ["We", "sought", "to", "determine", "the", "basis", "of", "the", "variable", "effect", "obtained", "with", "C1815010#ent", "<e1>", "in", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [17, 18]}}
{"token": ["Here", ",", "we", "show", "that", "L-selectin-dependent", "rolling", "after", "P-selectin", "blockade", "completely", "absent", "in", "C1419941#ent", "<e1>", "mice", "or", "wild-type", "mice", "treated", "with", "C1419941#ent", "<e1>", "blocking", "monoclonal", "antibody"], "h": {"id": "C1419941", "name": "C1419941#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1419941", "name": "C1419941#ent", "pos": [13, 14]}}
{"token": ["Although", "previous", "studies", "using", "mice", "lacking", "C1419941#ent", "<e1>", "C1419941#ent", "<e1>", ")", "have", "indicated", "that", "C1419941#ent", "<e1>", "on", "Th1", "cells", "functions", "as", "an", "E-selectin", "ligand", ",", "the", "molecular", "nature", "E-selectin", "ligands", "than", "C1419941#ent", "<e1>", "remains", "unknown", "."], "h": {"id": "C1419941", "name": "C1419941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419941", "name": "C1419941#ent", "pos": [6, 7]}}
{"token": ["He", "was", "diagnosed", "as", "disseminated", "C0275706#ent", "<e1>", "heart", "failure", "and", "was", "treated", "by", "anti-tuberculosis", "drugs", "C0012798#ent", "<e2>", "."], "h": {"id": "C0275706", "name": "C0275706#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [15, 16]}}
{"token": ["In", "vitro", "assays", "demonstrated", "the", "production", "by", "E.", "lata", "of", "C0031179#ent", "<e1>", ",", "glycosidases", "and", "C0054259#ent", "<e2>", "degrading", "enzymes", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [15, 16]}}
{"token": ["It", "is", "concluded", "that", "amelioration", "of", "C1142276#ent", "<e1>", "erythropoietin", "in", "dialysis", "patients", "with", "significant", "C0010054#ent", "<e2>", "exercise-induced", "myocardial", "ischemia", "."], "h": {"id": "C1142276", "name": "C1142276#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [14, 15]}}
{"token": ["C1136240#ent", "<e1>", "to", "an", "increasing", "list", "of", "targets", "of", "C1418898#ent", "<e2>", "in", "agreement", "with", "the", "inhibition", "of", "energy-consuming", "biosynthetic", "pathways"], "h": {"id": "C1136240", "name": "C1136240#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418898", "name": "C1418898#ent", "pos": [9, 10]}}
{"token": ["Mycobacterium", "tuberculosis", "the", "causative", "agent", "C0041323#ent", "<e1>", ",", "possesses", "four", "genes", "encoding", "C0031671#ent", "<e2>", "plcA", ",", "plcB", ",", "plcC", "and", "plcD.", "However", ",", "the", "contribution", "of", "these", "genes", "to", "virulence", "is", "unknown", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [12, 13]}}
{"token": ["Using", "yeast", "two-hybrid", "screening", ",", "we", "identified", "a", "novel", "C1332639#ent", "<e1>", "BRD7", ",", "as", "an", "C1424684#ent", "<e2>", "interaction", "partner", "."], "h": {"id": "C1332639", "name": "C1332639#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1424684", "name": "C1424684#ent", "pos": [15, 16]}}
{"token": ["Activation", "of", "C1955862#ent", "<e1>", "results", "from", "a", "cyclic", "AMP-mediated", "process", "due", "to", "C3489929#ent", "<e2>", "VIP", "release", "from", "neurons", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3489929", "name": "C3489929#ent", "pos": [12, 13]}}
{"token": ["When", "8-PT", "(", "10", "mumol/l", ")", "was", "added", "to", "the", "perfusion", "buffer", "to", "C3887648#ent", "<e1>", ",", "the", "incidence", "of", "VT", "and", "C0042510#ent", "<e2>", "increased", "to", "79", "and", "68", "%", ",", "respectively", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [21, 22]}}
{"token": ["C1334112#ent", "<e1>", "phorbol", "ester", "increased", "the", "levels", "of", "C0072055#ent", "<e2>", "(", "assayed", "after", "trypsin", "activation", "and", "the", "labeling", "of", "several", "medium", "proteins", "cells", "incubated", "with", "[35S]methionine", ",", "independent", "of", "prostaglandin", "synthesis"], "h": {"id": "C1334112", "name": "C1334112#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072055", "name": "C0072055#ent", "pos": [8, 9]}}
{"token": ["Fifteen", "patients", "with", "C0035258#ent", "<e1>", "whole-night", "polysomnographic", "recordings", "before", "and", "during", "C0009011#ent", "<e2>", "treatment", "."], "h": {"id": "C0035258", "name": "C0035258#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0009011", "name": "C0009011#ent", "pos": [11, 12]}}
{"token": ["Questions", "that", "assessed", "C0342257#ent", "<e1>", "victimization", "from", "teachers", "were", "administered", "to", "young", "people", "C0011860#ent", "<e2>"], "h": {"id": "C0342257", "name": "C0342257#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [13, 14]}}
{"token": ["Ten", "term", "pregnancy", "placentas", "from", "preeclampsic", "cases", ",", "uncomplicated", "by", "C0155583#ent", "<e1>", "IUGR", "or", "C0035086#ent", "<e2>", "studied", "by", "means", "of", "histomorphometric", "analysis", "the", "results", "were", "compared", "with", "10", "term", "pregnancy", "normal", "placentas", "."], "h": {"id": "C0155583", "name": "C0155583#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [14, 15]}}
{"token": ["The", "Galphai", "inhibitor", "C0043167#ent", "<e1>", "the", "JAK2", "inhibitor", "C0381241#ent", "<e2>", "abrogate", "the", "inhibitory", "effect", "of", "RC-160", "on", "HMW", "FGF-2-induced", "cell", "growth", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0381241", "name": "C0381241#ent", "pos": [8, 9]}}
{"token": ["These", "differences", "were", "associated", "with", "C1565830#ent", "<e1>", "inhibition", "by", "C0038792#ent", "<e2>", "(", "reflected", "by", "urinary", "thromboxane", "B2", "6-keto", "PGF1", "alpha", "than", "by", "other", "NSAIDs", "."], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [9, 10]}}
{"token": ["They", "were", "treated", "with", "mg", "tetrathiomolybdate/kg", "body", "weight", "and", "lactated", "Ringer's", "solution", ",", "oral", "molybdate", "sulfate", ",", "C0264435#ent", "<e1>", "and", "pectin", ",", "and", "drenched", "with", "C0003138#ent", "<e2>", "."], "h": {"id": "C0264435", "name": "C0264435#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003138", "name": "C0003138#ent", "pos": [25, 26]}}
{"token": ["Analysis", "of", "a", "battery", "of", "cell", "cycle", "proteins", "cyclin", "D1", "C1565306#ent", "<e1>", ",", "PCNA", ",", "cdc25A", "and", "C1413259#ent", "<e2>", ")", "indicated", "exposure-specific", "differential", "expression", "profiles"], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413259", "name": "C1413259#ent", "pos": [17, 18]}}
{"token": ["The", "microscopic", "appearance", "of", "C0221252#ent", "<e1>", "EX", ")", "presents", "the", "potential", "for", "misinterpretation", "as", "C0085074#ent", "<e2>", "GA", ")", "."], "h": {"id": "C0221252", "name": "C0221252#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085074", "name": "C0085074#ent", "pos": [14, 15]}}
{"token": ["We", "propose", "that", "C1415712#ent", "<e1>", "formation", "is", "required", "for", "the", "full", "cell", "migratory", "function", "C0165519#ent", "<e2>", "."], "h": {"id": "C1415712", "name": "C1415712#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0165519", "name": "C0165519#ent", "pos": [14, 15]}}
{"token": ["During", "the", "oocyte", "growth", "phase", "fibrillarin", ",", "C1334894#ent", "<e1>", ",", "nucleolin", ",", "RNA", "pol", "I", "and", "C1421307#ent", "<e2>", "were", "localized", "to", "the", "oocyte", "nucleolus"], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421307", "name": "C1421307#ent", "pos": [16, 17]}}
{"token": ["Hyperprolactinaemic", "hypogonadism", "adults", "is", "a", "well", "defined", "disease", "with", "clinical", "symptoms", "C0542031#ent", "<e1>", "amenorrhea", "and", "C3665358#ent", "<e2>", "in", "females", "and", "loss", "of", "sexual", "activity", "males", "."], "h": {"id": "C0542031", "name": "C0542031#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3665358", "name": "C3665358#ent", "pos": [15, 16]}}
{"token": ["Melatonin", "also", "inhibits", "the", "C1366535#ent", "<e1>", "release", "induced", "by", "C1366646#ent", "<e2>", "VIP", ")", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366646", "name": "C1366646#ent", "pos": [9, 10]}}
{"token": ["The", "most", "common", "causes", "of", "C0008031#ent", "<e1>", "in", "dental", "situations", "include", "hyperventilation", ",", "pulmonary", "embolism", "C0002962#ent", "<e2>", "myocardial", "infarction"], "h": {"id": "C0008031", "name": "C0008031#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [15, 16]}}
{"token": ["This", "study", "assessed", "chest", "pain", "locations/symptoms", "among", "patients", "who", "presented", "with", "C0008031#ent", "<e1>", "how", "these", "compare", "with", "a", "clinical", "diagnosis", "cardiac", "or", "C0002962#ent", "<e2>"], "h": {"id": "C0008031", "name": "C0008031#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [22, 23]}}
{"token": ["Currently", ",", "the", "C1332023#ent", "<e1>", "29", "members", ",", "although", "the", "function", "of", "most", "C1314771#ent", "<e2>", "gene", "products", "unknown", "."], "h": {"id": "C1332023", "name": "C1332023#ent", "pos": [3, 4]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C1314771", "name": "C1314771#ent", "pos": [13, 14]}}
{"token": ["We", "further", "show", "that", "C0025023#ent", "<e1>", "melanocytes", "can", "be", "sensitized", "through", "reduction", "of", "C0376515#ent", "<e2>", "levels", ",", "showing", "the", "essential", "role", "of", "Bcl-2", "in", "the", "cellular", "response", "mebendazole-mediated", "tubulin", "disruption", "."], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [13, 14]}}
{"token": ["No", "phosphorylated", "C1566790#ent", "<e1>", "was", "found", "in", "MEE", "in", "C1710291#ent", "<e2>", ")", "mice", ",", "although", "nonphosphorylated", "C1566790#ent", "<e1>", "was", "present", "."], "h": {"id": "C1566790", "name": "C1566790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1710291", "name": "C1710291#ent", "pos": [9, 10]}}
{"token": ["Specific", "and", "sensitive", "reverse", "transcription-PCR", "RT-PCR", ")", "assays", "were", "developed", "for", "the", "detection", "of", "eastern", ",", "western", ",", "and", "C0014078#ent", "<e1>", "EEE", ",", "WEE", ",", "and", "C0014078#ent", "<e1>", ",", "respectively", ")", "."], "h": {"id": "C0014078", "name": "C0014078#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0014078", "name": "C0014078#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "the", "complex", "formed", "by", "Rad50", ",", "C3273855#ent", "<e1>", ",", "and", "Xrs2", "proteins", "promotes", "intermolecular", "DNA", "joining", "by", "C0285266#ent", "<e2>", "Dnl4", ")", "and", "its", "associated", "protein", "Lif1", "."], "h": {"id": "C3273855", "name": "C3273855#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0285266", "name": "C0285266#ent", "pos": [22, 23]}}
{"token": ["Among", "11", "with", "C0006287#ent", "<e1>", "six", "with", "C0270171#ent", "<e2>", "only", "three", "died", "from", "C0270171#ent", "<e2>", "three", "had", "minor", "pulmonary", "symptoms", "but", "were", "healthy", "at", "one", "year", "of", "age", "."], "h": {"id": "C0006287", "name": "C0006287#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0270171", "name": "C0270171#ent", "pos": [7, 8]}}
{"token": ["Partially", "enriched", "fractions", "of", "either", "C1426677#ent", "<e1>", "or", "leukocytes", "from", "silica-treated", "rats", "both", "exhibited", "significantly", "elevated", "C1417760#ent", "<e2>", "mRNA", "in", "Northern", "analysis"], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [16, 17]}}
{"token": ["In", "vitro", "exposure", "of", "C1426677#ent", "<e1>", "to", "silica", "does", "not", "stimulate", ".NO", "production", "or", "enhance", "C1417760#ent", "<e2>", "message", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", "to", "receptor", "tyrosine", "kinases", "the", "signalling", "pathways", "to", "MAP", "kinase", "activation", "by", "C3539616#ent", "<e1>", "are", "poorly", "understood", "but", "appear", "to", "involve", "Grb2", "and", "C1705297#ent", "<e2>", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [25, 26]}}
{"token": ["Multiple", "immunofluorescence", "a", "high", "degree", "of", "colocalization", "of", "C1421467#ent", "<e1>", "with", "SP", "and", "CGRP", "in", "C1420709#ent", "<e2>", "neurons", "as", "well", "as", "in", "fibers", "and", "terminals", "confined", "to", "laminae", "I", "IIo", "of", "Vc", "."], "h": {"id": "C1421467", "name": "C1421467#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [15, 16]}}
{"token": ["Increased", "expression", "of", "CGRP", ",", "SP", ",", "P2X(3", ")", ",", "and", "C1421467#ent", "<e1>", "in", "the", "C1420709#ent", "<e2>", "may", "be", "involved", "in", "the", "behavioral", "changes", "in", "this", "model", "."], "h": {"id": "C1421467", "name": "C1421467#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [15, 16]}}
{"token": ["In", "another", "set", "of", "experiments", ",", "pharmacologically", "C0026961#ent", "<e1>", "normal", "subjects", "more", "to", "dilute", "C0770456#ent", "<e2>", "than", "their", "normal-sized", "fellow", "pupils", "."], "h": {"id": "C0026961", "name": "C0026961#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0770456", "name": "C0770456#ent", "pos": [14, 15]}}
{"token": ["To", "study", "the", "value", "of", "condensation", "and", "rarefaction", "clicks", "evoked", "action", "potential", "(", "AP", ")", "latency", "difference", "C1539521#ent", "<e1>", ")", "in", "diagnosis", "of", "C0025281#ent", "<e2>"], "h": {"id": "C1539521", "name": "C1539521#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0025281", "name": "C0025281#ent", "pos": [23, 24]}}
{"token": ["These", "results", "resolve", "many", "of", "the", "controversies", "concerning", "the", "Fe-S", "cluster", "content", "of", "C0038615#ent", "<e1>", "reconcile", "published", "C1366515#ent", "<e2>", "data", "with", "analytical", "and", "core", "extrusion", "studies", "."], "h": {"id": "C0038615", "name": "C0038615#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366515", "name": "C1366515#ent", "pos": [17, 18]}}
{"token": ["LTP", "was", "also", "not", "disrupted", "by", "postinduction", "application", "of", "a", "selective", "C0001641#ent", "<e1>", "of", "GluR2-lacking", "AMPA", "receptors", "the", "broad-spectrum", "glutamate", "receptor", "antagonist", "C0242369#ent", "<e2>", "."], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242369", "name": "C0242369#ent", "pos": [22, 23]}}
{"token": ["Elastic", "fibres", "the", "alveolar", "walls", "not", "show", "the", "fragmentation", "observed", "in", "the", "C1823517#ent", "<e1>", "mouse", ",", "and", "microfibrils", "surrounding", "C1414382#ent", "<e2>", "were", "clearly", "observed", "."], "h": {"id": "C1823517", "name": "C1823517#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [19, 20]}}
{"token": ["Consistently", ",", "overexpression", "of", "dominant-negative", "C4284779#ent", "<e1>", "increased", "the", "production", "of", "IL-2", ",", "C0812246#ent", "<e2>", ",", "and", "IFN-gamma", "in", "Th1", "cells"], "h": {"id": "C4284779", "name": "C4284779#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [13, 14]}}
{"token": ["When", "C4284779#ent", "<e1>", "expression", "was", "knocked", "down", "by", "C4284779#ent", "<e1>", "short", "interfering", "RNA", "the", "production", "of", "IL-2", ",", "C0812246#ent", "<e1>", ",", "and", "IFN-gamma", "by", "Th1", "cells", "response", "to", "TCR", "stimulation", "was", "enhanced", "."], "h": {"id": "C4284779", "name": "C4284779#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "experiments", "using", "C4284779#ent", "<e1>", "specific", "siRNA", "demonstrated", "that", "C4284779#ent", "<e1>", "is", "required", "for", "the", "C0812246#ent", "<e1>", "stimulation", "of", "MMP1", "."], "h": {"id": "C4284779", "name": "C4284779#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [16, 17]}}
{"token": ["A", "broad", "screen", "of", "liver", "gene", "expression", "showed", "no", "evidence", "of", "defects", "in", "C1421536#ent", "<e1>", "did", "identify", "genes", "that", "have", "increased", "expression", "levels", "in", "C3814450#ent", "<e2>", "knockouts", "."], "h": {"id": "C1421536", "name": "C1421536#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3814450", "name": "C3814450#ent", "pos": [24, 25]}}
{"token": ["Here", "we", "describe", "that", "a", "gene", "encoding", "the", "key", "C0027203#ent", "<e1>", "in", "cholic", "acid", "biosynthesis", "the", "C0038315#ent", "<e2>", "CYP8B1", ")", ",", "is", "in", "fact", "present", "in", "the", "pig", "genome", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038315", "name": "C0038315#ent", "pos": [16, 17]}}
{"token": ["Accumulation", "of", "the", "C1254351#ent", "<e1>", "because", "of", "C0443764#ent", "<e2>", "immaturity", "has", "been", "suggested", "to", "be", "the", "reason", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0443764", "name": "C0443764#ent", "pos": [7, 8]}}
{"token": ["We", "report", "a", "13-year-old", "girl", "with", "dentatorubal-pallidoluysian", "atrophy", "C1540211#ent", "<e1>", ")", ",", "presenting", "clinically", "as", "progressive", "C0393702#ent", "<e2>"], "h": {"id": "C1540211", "name": "C1540211#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0393702", "name": "C0393702#ent", "pos": [16, 17]}}
{"token": ["To", "investigate", "the", "relationship", "between", "TNFalpha", "and", "C1825546#ent", "<e1>", "induced", "by", "a", "single", "dose", "C0025241#ent", "<e2>", "in", "C57BL/6", "mice"], "h": {"id": "C1825546", "name": "C1825546#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [14, 15]}}
{"token": ["Given", "the", "need", "for", "lifelong", "therapy", "for", "C0010823#ent", "<e1>", "some", "human", "immunodeficiency", "virus-positive", "patients", ",", "C0909381#ent", "<e2>", "is", "a", "welcome", "alternative", "to", "long-term", "administration", "of", "intravenous", "antivirals"], "h": {"id": "C0010823", "name": "C0010823#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0909381", "name": "C0909381#ent", "pos": [15, 16]}}
{"token": ["In", "a", "randomized", ",", "international", "trial", "recipients", "with", "C0010823#ent", "<e1>", "treated", "with", "900", "mg", "oral", "C0909381#ent", "<e2>", "or", "5", "mg/kg", "i.v", "."], "h": {"id": "C0010823", "name": "C0010823#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0909381", "name": "C0909381#ent", "pos": [15, 16]}}
{"token": ["This", "C3813215#ent", "<e1>", "found", "to", "be", "an", "C0001473#ent", "<e2>", "that", "has", "been", "characterized", "in", "inside-out", "membrane", "vesicles", "and", "in", "proteoliposomes", "in", "which", "solubilized", "C0001473#ent", "<e2>", "was", "reconstituted", "."], "h": {"id": "C3813215", "name": "C3813215#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [7, 8]}}
{"token": ["C0012524#ent", "<e1>", "isolated", "from", "skin", "and", "serum", "samples", "of", "patients", "with", "C0023348#ent", "<e2>", "the", "specificity", "of", "a", "bacterially", "derived", "enzyme", "and", "not", "that", "of", "a", "mammalian-derived", "enzyme", "."], "h": {"id": "C0012524", "name": "C0012524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023348", "name": "C0023348#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "the", "results", "of", "experiments", "using", "certain", "esterase", "inhibitors", "suggested", "the", "major", "contribution", "of", "C0054741#ent", "<e1>", ")", "in", "the", "metabolism", "of", "C0292750#ent", "<e2>", "to", "SM", "particularly", "in", "serum", "and", "intestinal", "fluid"], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0292750", "name": "C0292750#ent", "pos": [23, 24]}}
{"token": ["Among", "hematological", "items", "the", "average", "platelet", "count", "the", "C1418587#ent", "<e1>", "group", "was", "significantly", "lower", "than", "that", "of", "the", "C0012695#ent", "<e2>", "group", ",", "due", "to", "platelet", "aggregation", "the", "C1418587#ent", "<e1>", "group", "."], "h": {"id": "C1418587", "name": "C1418587#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [18, 19]}}
{"token": ["Hes6", "inhibits", "the", "interaction", "of", "C1412958#ent", "<e1>", "with", "its", "C1336779#ent", "<e2>", "."], "h": {"id": "C1412958", "name": "C1412958#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336779", "name": "C1336779#ent", "pos": [9, 10]}}
{"token": ["Knockdown", "of", "C3815276#ent", "<e1>", "causes", "stabilization", "of", "Wee1", "and", "increased", "phosphorylation", "of", "C1332721#ent", "<e2>", "at", "the", "inhibitory", "Tyr15", "."], "h": {"id": "C3815276", "name": "C3815276#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332721", "name": "C1332721#ent", "pos": [12, 13]}}
{"token": ["C0009186#ent", "<e1>", "frequently", "accompanied", "by", "C1306759#ent", "<e2>", "in", "the", "range", "of", "5%-10", "%", "of", "the", "peripheral", "white", "blood", "cell", "count"], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [5, 6]}}
{"token": ["The", "gene", "that", "encodes", "this", "C1333877#ent", "<e1>", "is", "located", "between", "the", "C1567160#ent", "<e2>", "cathepsin", "G", "genes", "human", "chromosome", "14q11.2"], "h": {"id": "C1333877", "name": "C1333877#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1567160", "name": "C1567160#ent", "pos": [11, 12]}}
{"token": ["At", "low", "initial", "C1161331#ent", "<e1>", "concentrations", ",", "in", "the", "absence", "of", "C0119421#ent", "<e2>", "stoichiometric", "yields", "of", "1", "mol", "of", "H2/mol", "of", "C1161331#ent", "<e1>", "were", "achieved", "."], "h": {"id": "C0119421", "name": "C0119421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [3, 4]}}
{"token": ["Ecotopic", "expression", "of", "NF-E2", "related", "factors", "showed", "that", "C1414905#ent", "<e1>", ",", "but", "not", "C1417846#ent", "<e2>", ",", "Nrf3", ",", "or", "Bach1", ",", "activated", "TXAS", "promoter", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C1414905", "name": "C1414905#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417846", "name": "C1417846#ent", "pos": [13, 14]}}
{"token": ["C1414905#ent", "<e1>", "is", "more", "potent", "than", "C1417846#ent", "<e2>", "in", "activation", "of", "ARE-regulated", "gene", "expression", "."], "h": {"id": "C1414905", "name": "C1414905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417846", "name": "C1417846#ent", "pos": [6, 7]}}
{"token": ["Our", "experiment", "indicates", "that", "the", "C1704723#ent", "<e1>", "may", "be", "a", "C1332838#ent", "<e2>", "knocking", "foreign", "gene", "make", "transgenic", "animals"], "h": {"id": "C1704723", "name": "C1704723#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332838", "name": "C1332838#ent", "pos": [10, 11]}}
{"token": ["Using", "metabolically", "32P-labelled", "human", "platelets", ",", "tyrphostins", "also", "inhibited", "phosphorylation", "of", "C1419881#ent", "<e1>", ",", "the", "main", "substrate", "for", "C0033634#ent", "<e2>", "and", "myosin", "light", "chain", "at", "short", "periods", "of", "activation", "."], "h": {"id": "C1419881", "name": "C1419881#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [18, 19]}}
{"token": ["To", "characterize", "further", "P256-induced", "activation", ",", "the", "phosphorylation", "of", "C1419881#ent", "<e1>", ",", "the", "main", "substrate", "of", "C0033634#ent", "<e2>", "PKC", ")", "and", "the", "phosphorylation", "of", "tyrosine", "protein", "P-Tyr", ")", "was", "also", "studied", "."], "h": {"id": "C1419881", "name": "C1419881#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [16, 17]}}
{"token": ["PDGF", "also", "completely", "prevented", "phosphorylation", "of", "C1419881#ent", "<e1>", "and", "P20", ",", "as", "a", "result", "of", "C0033634#ent", "<e2>", "consecutive", "to", "phosphoinositide", "metabolism"], "h": {"id": "C1419881", "name": "C1419881#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "the", "immunocytochemical", "localization", "of", "C0007367#ent", "<e1>", "and", "three", "peroxisomal", "lipid", "beta-oxidation", "enzymes", ":", "acyl-CoA", "oxidase", "C1413078#ent", "<e2>", "enoyl-CoA", "hydratase", "3-hydroxyacyl-CoA", "dehydrogenase", "and", "3-ketoacyl-CoA", "thiolase", "in", "human", "renal", "biopsies", "with", "glutaraldehyde", "and", "embedded", "in", "Epon", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413078", "name": "C1413078#ent", "pos": [17, 18]}}
{"token": ["The", "efficacy", "of", "C0011816#ent", "<e1>", "(", "DM", ")", "for", "treating", "C0010200#ent", "<e2>", "uncertain", ",", "and", "its", "use", "is", "not", "supported", "by", "the", "American", "Academy", "of", "Pediatrics", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [10, 11]}}
{"token": ["Clopidogrel", "abolishes", "the", "inhibitory", "P2Y(AC", ")", "receptor-mediated", "ADP", "effects", "on", "prostaglandin", "E(1)-stimulated", ",", "C1514550#ent", "<e1>", "phosphorylation", "of", "C1421428#ent", "<e2>", "without", "affecting", "epinephrine", ",", "thrombin", ",", "and", "thromboxane", "signaling"], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1421428", "name": "C1421428#ent", "pos": [17, 18]}}
{"token": ["Indeed", ",", "preventing", "Akt", "and", "C0244988#ent", "<e1>", "phosphorylations", "by", "C2936824#ent", "<e2>", "PI3K", "inhibition", "abolished", "protection", "by", "EPO", "against", "cardiomyocyte", "loss", "apoptosis", ",", "and", "oxidative", "stress"], "h": {"id": "C0244988", "name": "C0244988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [9, 10]}}
{"token": ["C2721771#ent", "<e1>", "mouth", "washes", "started", "5", "days", "after", "methotrexate", "administration", "to", "prevent", "C0009763#ent", "<e2>", "and", "mucositis", "as", "a", "result", "of", "high", "methotrexate", "levels", "(", ">", "2.4", "micromol/l", ")", "."], "h": {"id": "C2721771", "name": "C2721771#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [12, 13]}}
{"token": ["C3831543#ent", "<e1>", "AMPK", ")", "regulatory", "gamma2", "subunit", "(", "C1418905#ent", "<e2>", ")", "mutations", "cause", "a", "human", "cardiomyopathy", "with", "cardiac", "hypertrophy", "preexcitation", ",", "and", "glycogen", "deposition"], "h": {"id": "C3831543", "name": "C3831543#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418905", "name": "C1418905#ent", "pos": [8, 9]}}
{"token": ["Multiple", "sclerosis", "C3539704#ent", "<e1>", ")", "is", "a", "complicated", "C0752235#ent", "<e2>", "an", "unknown", "cause", "and", "cure", "."], "h": {"id": "C3539704", "name": "C3539704#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [8, 9]}}
{"token": ["Six", "of", "the", "13", "clinically", "definite", "C3539704#ent", "<e1>", "patients", "had", "elevated", "levels", "of", "antibodies", "compared", "with", "other", "C0752235#ent", "<e2>", "orthopaedic", "controls"], "h": {"id": "C3539704", "name": "C3539704#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [17, 18]}}
{"token": ["Item", "and", "scale", "analysis", "that", "for", "C3539704#ent", "<e1>", "patients", ",", "endorsement", "of", "items", "that", "reflected", "the", "C0752235#ent", "<e2>", "led", "to", "artificial", "elevation", "four", "clinical", "scales"], "h": {"id": "C3539704", "name": "C3539704#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "overexpression", "of", "C1332800#ent", "<e1>", "in", "ARF-expressing", "cells", "enhanced", "cell", "migration", "and", "an", "C0525037#ent", "<e2>", "mutant", "defective", "in", "CtBP-family", "binding", "was", "impaired", "in", "its", "ability", "to", "inhibit", "cell", "migration", "induced", "by", "C1332800#ent", "<e1>", "."], "h": {"id": "C1332800", "name": "C1332800#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [14, 15]}}
{"token": ["This", "C0010481#ent", "<e1>", "is", "corrected", "by", "C0002555#ent", "<e2>", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0002555", "name": "C0002555#ent", "pos": [6, 7]}}
{"token": ["The", "present", "results", "also", "show", "that", "Ghrelin", "interacts", "with", "GHRH", "and", "C0085077#ent", "<e1>", "to", "in", "the", "release", "of", "C3539616#ent", "<e2>", "from", "porcine", "adenohypophysial", "cells"], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [18, 19]}}
{"token": ["Two", "hormones", "principally", "regulate", "the", "secretion", "of", "C3539616#ent", "<e1>", ":", "growth", "hormone-releasing", "hormone", "GHRH", ")", "stimulates", ",", "while", "somatostatin", "(", "C0085077#ent", "<e2>", ")", "inhibits", "the", "secretion", "of", "C3539616#ent", "<e1>", "."], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [7, 8]}}
{"token": ["The", "aims", "of", "this", "work", "were", "to", "study", "C0085077#ent", "<e1>", "tone", "in", "cirrhotic", "animals", "and", "to", "evaluate", "whether", "IGF-I", "treatment", "influences", "C0085077#ent", "<e1>", "tone", ",", "controlling", "C3539616#ent", "<e1>", "secretion", "in", "cirrhosis", "."], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [26, 27]}}
{"token": ["Apoptosis", "was", "characterised", "by", ":", "change", "in", "mitochondrial", "potential", ",", "caspase-3", "cleavage", "down-regulation", "of", "mRNA", "and", "protein", "for", "C1332416#ent", "<e1>", ",", "XIAP", ",", "IAP1", ",", "IAP2", "and", "C1332397#ent", "<e2>", ",", "inhibition", "by", "caspase-3", "inhibitor"], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [27, 28]}}
{"token": ["C1332416#ent", "<e1>", "also", "decreased", "in", "response", "to", "PVP-I", "whereas", "C1332397#ent", "<e2>", "remained", "unaffected", "by", "both", "treatments", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [9, 10]}}
{"token": ["Before", "the", "therapy", ",", "the", "C1706005#ent", "<e1>", "and", "IgG", "auto-antibodies", "against", "C1415287#ent", "<e2>", "GluR", ")", "epsilon", "2", "and", "delta", "2", "positive", ",", "however", "they", "became", "negative", "after", "the", "therapy", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415287", "name": "C1415287#ent", "pos": [11, 12]}}
{"token": ["Multiple-cause", "tapes", "also", "permitted", "a", "review", "of", "the", "association", "of", "deaths", "attributed", "to", "C0025007#ent", "<e1>", "and", "varicella", "and", "known", "complications", "of", "these", "C0029896#ent", "<e2>", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [22, 23]}}
{"token": ["The", "present", "data", "indicate", "that", "C0025007#ent", "<e1>", "and", "rubella", ",", "increasingly", "consequential", "C0029896#ent", "<e2>", "among", "young", "adults", "can", "be", "safely", "and", "effectively", "controlled", "with", "attenuated", "viral", "vaccines"], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [12, 13]}}
{"token": ["However", ",", "Dna2p", "has", "a", "role", "in", "a", "pathway", "for", "processing", "structured", "flaps", ",", "in", "which", "it", "aids", "C0252912#ent", "<e1>", "using", "both", "its", "C0597094#ent", "<e2>", "and", "helicase", "activities", "."], "h": {"id": "C0252912", "name": "C0252912#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0597094", "name": "C0597094#ent", "pos": [23, 24]}}
{"token": ["These", "cells", "were", "CD20+", "CD3-", ",", "CD45RO-", ",", "KP-1-", ",", "PGM1-", ",", "with", "occasional", "positive", "reaction", "C1413238#ent", "<e1>", "and", "CD74", ",", "indicating", "their", "B-cell", "nature", "i.e.", ",", "C2346907#ent", "<e2>", "."], "h": {"id": "C1413238", "name": "C1413238#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2346907", "name": "C2346907#ent", "pos": [27, 28]}}
{"token": ["Comparative", "data", "from", "patients", "with", "C0700345#ent", "<e1>", "that", "itraconazole", "is", "at", "least", "as", "effective", "as", "C0009074#ent", "<e2>", "oral", "fluconazole", "and", "superior", "to", "intravaginal", "econazole", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0009074", "name": "C0009074#ent", "pos": [15, 16]}}
{"token": ["The", "modern", "treatment", "C0700345#ent", "<e1>", "imidazole", "antimycotics", "such", "as", "C0009074#ent", "<e2>", "has", "been", "shown", "to", "be", "highly", "effective", "."], "h": {"id": "C0700345", "name": "C0700345#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0009074", "name": "C0009074#ent", "pos": [9, 10]}}
{"token": ["The", "etiology", "of", "stroke", "in", "diabetics", "is", "frequently", "C0042373#ent", "<e1>", "fibrinoid", "necrosis", "which", "causes", "small", "subcortical", "infarcts", "designated", "as", "C0038454#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [19, 20]}}
{"token": ["Percent", "decrease", "of", "GFR", "by", "C0056572#ent", "<e1>", "was", "significantly", "less", "than", "that", "by", "nicardipine", "although", "both", "C0991617#ent", "<e2>", "produced", "almost", "the", "same", "degree", "of", "peak", "hypotension"], "h": {"id": "C0056572", "name": "C0056572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}}
{"token": ["Recurrent", "C0020615#ent", "<e1>", "did", "not", "enhance", "C0017920#ent", "<e2>", "depletion", "or", "the", "markedly", "impaired", "glucocorticoid", "and", "epinephrine", "responses", "to", "C0020615#ent", "<e1>", "in", "CRH", "KO", "mice", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [6, 7]}}
{"token": ["It", "was", "the", "aim", "of", "this", "study", "to", "elucidate", "the", "mechanisms", "for", "milder", "C0020615#ent", "<e1>", "symptoms", "in", "young", "adult", "C0017920#ent", "<e2>", "patients", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0017920", "name": "C0017920#ent", "pos": [19, 20]}}
{"token": ["In", "endemic", "areas", ",", "the", "clinical", "spectrum", "C0158369#ent", "<e1>", "lymphangitis", ",", "or", "C0013884#ent", "<e2>", "is", "usually", "recognized", "as", "filariasis", "."], "h": {"id": "C0158369", "name": "C0158369#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013884", "name": "C0013884#ent", "pos": [12, 13]}}
{"token": ["Thyroid", "function", "disorders", "associated", "with", "neonatal", "adaptation", "and", "illness", "also", "are", "reviewed", ";", "these", "include", "transient", "hypothyroxinemia", ",", "transient", "C0700502#ent", "<e1>", "and", "the", "C0039082#ent", "<e2>", "of", "nonthyroidal", "illness"], "h": {"id": "C0700502", "name": "C0700502#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [23, 24]}}
{"token": ["We", "report", "a", "girl", "with", "C0700502#ent", "<e1>", "by", "growth", "retardation", "a", "C0039082#ent", "<e2>", "of", "primary", "amenorrhea-galactorrhea", "with", "hyperprolactinemia", "and", "suprasellar", "pituitary", "enlargement", "."], "h": {"id": "C0700502", "name": "C0700502#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [11, 12]}}
{"token": ["The", "expression", "of", "YRS1", "was", "induced", "strikingly", "by", "reveromycin", "A.", "These", "results", "suggest", "that", "C1337037#ent", "<e1>", "is", "a", "multispecific", "C1420141#ent", "<e2>", "for", "tolerance", "against", "toxic", "environmental", "organic", "anions"], "h": {"id": "C1337037", "name": "C1337037#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420141", "name": "C1420141#ent", "pos": [19, 20]}}
{"token": ["C0026056#ent", "<e1>", "on", "the", "other", "hand", "prevented", "the", "increase", "of", "C1704793#ent", "<e2>", "and", "beta-endorphin", "levels", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [10, 11]}}
{"token": ["Proangiotensin-12", "constricted", "aortic", "strips", ",", "when", "infused", "intravenously", ",", "raised", "blood", "pressure", "rats", ",", "while", "both", "the", "vasoconstrictor", "and", "pressor", "response", "to", "proangiotensin-12", "were", "abolished", "by", "C0006938#ent", "<e1>", "and", "by", "C0217087#ent", "<e2>", ",", "an", "Ang", "II", "type", "I", "receptor", "blocker"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0217087", "name": "C0217087#ent", "pos": [30, 31]}}
{"token": ["The", "residues", "contributing", "to", "the", "binding", "site", "the", "antagonist", ",", "C0141756#ent", "<e1>", ",", "and", "the", "C0243192#ent", "<e2>", ",", "acetylcholine", "have", "been", "mapped", "."], "h": {"id": "C0141756", "name": "C0141756#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [15, 16]}}
{"token": ["Taken", "together", ",", "our", "findings", "indicate", "that", "IL-1-induced", "intracellular", "signaling", "pathways", "in", "the", "activation", "of", "MAP", "kinase", "C1442514#ent", "<e1>", "the", "subsequent", "phosphorylation", "of", "C1708296#ent", "<e2>", "."], "h": {"id": "C1442514", "name": "C1442514#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1708296", "name": "C1708296#ent", "pos": [23, 24]}}
{"token": ["Genes", "encoding", "C0070781#ent", "<e1>", "selected", "from", "a", "10(7)-fold", "excess", "of", "C1417679#ent", "<e2>", "encoding", "another", "enzyme", "."], "h": {"id": "C0070781", "name": "C0070781#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["Captopril", "is", "a", "promising", "new", "C0042397#ent", "<e1>", "is", "efficacious", "in", "combination", "with", "C0001645#ent", "<e2>"], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [12, 13]}}
{"token": ["C0010592#ent", "<e1>", "CyA", ")", "was", "given", "to", "five", "patients", "with", "active", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e2>", ")", "at", "a", "dose", "of", "10", "mg/kg/day", "orally", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "effect", "of", "cyclosporin", "A", "C0010592#ent", "<e1>", ")", "on", "the", "development", "of", "C0024141#ent", "<e2>", "in", "an", "experimental", "model"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [14, 15]}}
{"token": ["This", "paper", "describes", "2", "patients", ",", "one", "with", "C0038013#ent", "<e1>", "the", "other", "with", "C0042951#ent", "<e2>", "the", "left", "forearm", "who", "are", "able", "to", "carry", "out", "CAPD", "successfully", "with", "the", "aid", "of", "bioengineering", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042951", "name": "C0042951#ent", "pos": [13, 14]}}
{"token": ["Conformational", "and", "electrostatic", "analysis", "C0065180#ent", "<e1>", "indicated", "that", "its", "structure", "is", "consistent", "with", "substrate", "models", "the", "C3887685#ent", "<e2>", "enzyme", "."], "h": {"id": "C0065180", "name": "C0065180#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [16, 17]}}
{"token": ["The", "results", "indicated", "that", "C0065180#ent", "<e1>", "was", "metabolized", "to", "DCL", "primarily", "by", "the", "CYP3A4", "and", "C3887685#ent", "<e2>", "enzymes", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0065180", "name": "C0065180#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [15, 16]}}
{"token": ["A", "patient", "with", "a", "history", "of", "diabetes", "mellitus", "C0018802#ent", "<e1>", "taking", "furosemide", "and", "C0025854#ent", "<e2>", "as", "diuretics", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0025854", "name": "C0025854#ent", "pos": [13, 14]}}
{"token": ["A", "case", "of", "C0016037#ent", "<e1>", "presented", ",", "in", "which", "C0018777#ent", "<e2>", "one", "of", "the", "typical", "clinical", "features", "."], "h": {"id": "C0016037", "name": "C0016037#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0018777", "name": "C0018777#ent", "pos": [9, 10]}}
{"token": ["The", "plasma", "levels", "of", "GH", "(", "C0033551#ent", "<e1>", ")", "and", "of", "C1947982#ent", "<e2>", "pGHBP", ")", "were", "also", "studied", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1947982", "name": "C1947982#ent", "pos": [11, 12]}}
{"token": ["C1705889#ent", "<e1>", "1", "nM", "was", "even", "more", "C0007209#ent", "<e2>", "(", "71", "%", "recovery", ")", "."], "h": {"id": "C1705889", "name": "C1705889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [7, 8]}}
{"token": ["To", "delineate", "the", "participation", "of", "C1705889#ent", "<e1>", "in", "the", "C0007209#ent", "<e2>", "ACE", "inhibitors", "experiments", "were", "performed", "in", "rats", "and", "dogs", "with", "cardiac", "ischemia-reperfusion", "injuries"], "h": {"id": "C1705889", "name": "C1705889#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [9, 10]}}
{"token": ["The", "authors", "report", "their", "own", "experiences", "of", "treatment", "with", "C0040615#ent", "<e1>", "child", "psychiatry", "haloperidol", ",", "pimozide", ",", "C0030815#ent", "<e2>", ",", "sulpiride", ")", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030815", "name": "C0030815#ent", "pos": [17, 18]}}
{"token": ["With", "respect", "to", "the", "effects", "of", "C4283784#ent", "<e1>", "on", "C0003850#ent", "<e2>", "our", "findings", "suggest", "that", "the", "anti-inflammatory", "effect", "C4283784#ent", "<e1>", "is", "at", "least", "partially", "responsible", "for", "the", "anti-atherogenic", "effects", "of", "C4283784#ent", "<e1>", "observed", "in", "vivo"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [6, 7]}}
{"token": ["Reduction", "in", "C0003850#ent", "<e1>", "has", "been", "reported", "in", "experimental", "animals", "fed", "mixtures", "of", "conjugated", "linoleic", "acid", "C4283784#ent", "<e2>", ")", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [16, 17]}}
{"token": ["Insofar", "as", "individual", "effects", "C0003850#ent", "<e1>", "were", "concerned", ",", "there", "was", "no", "difference", "between", "the", "C4283784#ent", "<e2>", "mix", "and", "the", "cis9,trans11", "and", "trans10,cis12", "isomers", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4283784", "name": "C4283784#ent", "pos": [15, 16]}}
{"token": ["C0001883#ent", "<e1>", "airways", "hyperresponsiveness", "two", "dominant", "features", "in", "patients", "with", "C0746102#ent", "<e2>", "asthma", "and", "chronic", "obstructive", "pulmonary", "disease", "COPD", ")", ")", "."], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0746102", "name": "C0746102#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "C0010976#ent", "<e1>", "were", "investigated", "on", "C0007028#ent", "<e2>", "CA", ")", "enzyme", "activities", "in", "in", "vitro", "human", "and", "in", "in", "vivo", "Sprague-Dawley", "rat", "erythrocytes", "."], "h": {"id": "C0010976", "name": "C0010976#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007028", "name": "C0007028#ent", "pos": [8, 9]}}
{"token": ["A", "series", "of", "244", "renal", "biopsy", "specimens", "obtained", "from", "patients", "with", "C0017658#ent", "<e1>", "included", "21", "from", "patients", "with", "C0017665#ent", "<e2>", "MN", ")", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0017665", "name": "C0017665#ent", "pos": [18, 19]}}
{"token": ["Glomerular", "diseases", "in", "this", "population", "include", "classic", "focal", "segmental", "glomerulosclerosis", "IgA", "nephropathy", "C0017658#ent", "<e1>", "hepatitis", "B-", "and", "C-related", "glomerulonephritides", "and", "C0017665#ent", "<e2>"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0017665", "name": "C0017665#ent", "pos": [20, 21]}}
{"token": ["C1442521#ent", "<e1>", "T", "cells", "bound", "better", "to", "C1706331#ent", "<e2>", "than", "PB", "T", "cells"], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [7, 8]}}
{"token": ["C1539127#ent", "<e1>", "is", "the", "first", "C4042946#ent", "<e2>", "to", "localize", "to", "the", "Golgi", "membrane"], "h": {"id": "C1539127", "name": "C1539127#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4042946", "name": "C4042946#ent", "pos": [5, 6]}}
{"token": ["Evidence", "of", "C0015624#ent", "<e1>", "lupus", "non-nephritis", "patients", "may", "help", "to", "identify", "C4053959#ent", "<e2>", "to", "the", "onset", "of", "albuminuria", "."], "h": {"id": "C0015624", "name": "C0015624#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [11, 12]}}
{"token": ["Proximal", "C0015624#ent", "<e1>", "frequent", "in", "patients", "with", "C4053959#ent", "<e2>"], "h": {"id": "C0015624", "name": "C0015624#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [7, 8]}}
{"token": ["Binding", "to", "C1412332#ent", "<e1>", "may", "be", "more", "significant", "than", "binding", "to", "C1413150#ent", "<e2>", "in", "controlling", "the", "transfer", "rate", "cortisol", "to", "the", "fetus", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413150", "name": "C1413150#ent", "pos": [11, 12]}}
{"token": ["Pediatric", "studies", "using", "gabapentin", "and", "C0772200#ent", "<e1>", "disclosed", "encouraging", "results", "in", "partial", "C0014547#ent", "<e2>", "."], "h": {"id": "C0772200", "name": "C0772200#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "immunoprecipitated", "C1419992#ent", "<e1>", "is", "phosphorylated", "by", "recombinant", "C4283740#ent", "<e2>", "."], "h": {"id": "C1419992", "name": "C1419992#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [9, 10]}}
{"token": ["Activation", "of", "PLD", "by", "C1705725#ent", "<e1>", "was", "dose-dependently", "inhibited", "by", "erbstatin", ",", "an", "inhibitor", "of", "C0033681#ent", "<e2>"], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [15, 16]}}
{"token": ["The", "results", "were", "compared", "with", "those", "obtained", "in", "a", "group", "of", "13", "C0004096#ent", "<e1>", "patients", "with", "C0024117#ent", "<e2>", "26", "healthy", "control", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [16, 17]}}
{"token": ["Spontaneous", "production", "and", "PMA-", "and", "opsonized", "zymosan-", "stimulated", "generation", "of", "superoxide", "anion", "blood", "cells", "C0004096#ent", "<e1>", "patients", "were", "compared", "with", "those", "in", "normal", "volunteers", "chronic", "obstructive", "pulmonary", "disease", "C0024117#ent", "<e2>", ")", "patients", "using", "a", "lucigenin-dependent", "chemiluminescence", "method", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [28, 29]}}
{"token": ["Cultured", "rat", "sympathetic", "neurons", "from", "postnatal", "rat", "superior", "cervical", "ganglia", "C0012694#ent", "<e1>", ")", "were", "used", "to", "compare", "the", "neurotoxicity", "of", "several", "C0008391#ent", "<e2>"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008391", "name": "C0008391#ent", "pos": [21, 22]}}
{"token": ["Research", "in", "the", "last", "25", "yr", "has", "made", "great", "advances", "in", "the", "understanding", "of", "the", "progression", "of", "C1561643#ent", "<e1>", "diabetic", "and", "C0011881#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [21, 22]}}
{"token": ["In", "conclusion", ",", "this", "study", "demonstrates", "that", "clozapine", "and", "one", "of", "its", "major", "metabolites", "in", "man", ",", "C0068971#ent", "<e1>", ",", "are", "potent", "C2936517#ent", "<e2>"], "h": {"id": "C0068971", "name": "C0068971#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2936517", "name": "C2936517#ent", "pos": [22, 23]}}
{"token": ["The", "same", "applies", "to", "liposomally", "encapsulated", "C0013547#ent", "<e1>", "with", "respect", "to", "C0040259#ent", "<e2>"], "h": {"id": "C0013547", "name": "C0013547#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [11, 12]}}
{"token": ["To", "be", "eligible", "for", "study", ",", "patients", "with", "C0376175#ent", "<e1>", "to", "be", "seen", "within", "10", "days", "of", "onset", "of", "C3714552#ent", "<e2>", "."], "h": {"id": "C0376175", "name": "C0376175#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [19, 20]}}
{"token": ["However", "C0376175#ent", "<e1>", "difficulty", "in", "swallowing", "food", "C3714552#ent", "<e2>", ",", "dysautonomia", "and", "respiratory", "failure", "progressed", "within", "5", "days", "after", "the", "onset", "."], "h": {"id": "C0376175", "name": "C0376175#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [7, 8]}}
{"token": ["APPC", "was", "considered", "to", "be", "an", "excellent", "C1254351#ent", "<e1>", "for", "the", "treatment", "of", "C0008311#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008311", "name": "C0008311#ent", "pos": [13, 14]}}
{"token": ["Also", "required", "are", "C0068800#ent", "<e1>", "encoded", "by", "the", "narGHJI", "operon", ",", "and", "C1422492#ent", "<e2>", ",", "involved", "in", "biosynthesis", "of", "a", "molybdopterin", "cofactor", "nitrate", "reductase"], "h": {"id": "C0068800", "name": "C0068800#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [12, 13]}}
{"token": ["Rhodioloside", ",", "and", "tyrosol", "were", "identified", "as", "active", "principles", "the", "extract", ",", "whereas", "C2354056#ent", "<e1>", ",", "rosarin", ",", "rosin", ",", "cinnamic", "alcohol", "cinnamaldehyde", ",", "C0055753#ent", "<e2>", "inactive", "."], "h": {"id": "C2354056", "name": "C2354056#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0055753", "name": "C0055753#ent", "pos": [24, 25]}}
{"token": ["Manipulating", "the", "aberrant", "apoptosis-associated", "DNA", "synthesis", "that", "occurs", "with", "C0752308#ent", "<e1>", "and", "perhaps", "neurodegenerative", "diseases", "promote", "C1420257#ent", "<e2>", "neurogenesis", "."], "h": {"id": "C0752308", "name": "C0752308#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [16, 17]}}
{"token": ["The", "concentration", "dependence", "of", "G", "alpha", "11", "activation", "of", "turkey", "erythrocyte", "phospholipase", "C", "C1377871#ent", "<e1>", "as", "well", "as", "the", "concentration", "dependence", "of", "the", "two", "C3540772#ent", "<e2>", "for", "activation", "by", "G", "alpha", "11", "were", "very", "similar", "."], "h": {"id": "C1377871", "name": "C1377871#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [24, 25]}}
{"token": ["Cyclosporine", ",", "microemulsion", "cyclosporine", "tacrolimus", ",", "and", "C0209368#ent", "<e1>", "be", "considered", "for", "the", "treatment", "of", "patients", "with", "refractory", "C1290884#ent", "<e2>", "fistulizing", "Crohn's", "disease", "and", "severe", "ulcerative", "colitis"], "h": {"id": "C0209368", "name": "C0209368#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [18, 19]}}
{"token": ["The", "therapeutic", "potential", "of", "several", "other", "agents", ",", "such", "as", "alpha(3)-adrenoceptor", "agonists", ",", "C2936568#ent", "<e1>", "phosphodiesterase", "inhibitors", "neurokinin-1", "receptor", "antagonists", "opioids", ",", "and", "C3537035#ent", "<e2>", "is", "also", "under", "investigation", "for", "the", "treatment", "of", "OAB", "."], "h": {"id": "C2936568", "name": "C2936568#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3537035", "name": "C3537035#ent", "pos": [23, 24]}}
{"token": ["C1822749#ent", "<e1>", "was", "measured", "in", "duplicate", "before", "and", "after", "acute", "ganglionic", "blockade", "C0062637#ent", "<e2>", "(", "30", "mg/kg", "i.v", ".", ")"], "h": {"id": "C1822749", "name": "C1822749#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0062637", "name": "C0062637#ent", "pos": [12, 13]}}
{"token": ["Owing", "to", "advances", "in", "both", "immunosuppressive", "protocols", "pancreatic", "islet", "isolation", "techniques", ",", "insulin", "independence", "has", "recently", "been", "achieved", "in", "C0011854#ent", "<e1>", "IDDM", ")", "via", "pancreatic", "islet", "transplantation", "C2697656#ent", "<e2>", ")", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [27, 28]}}
{"token": ["In", "32", "C0011854#ent", "<e1>", "individuals", "the", "lipopolysaccharide", "(", "C2697656#ent", "<e2>", ")", "stimulated", "monocytic", "TNF", "alpha", "secretion", "dose-response", "characteristics", "were", "analyzed", "and", "related", "to", "two", "different", "periodontal", "status", "categories", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}}
{"token": ["The", "four", "isomers", "of", "C0020404#ent", "<e1>", "have", "been", "tested", "as", "substrates", "and", "inhibitors", "for", "citrate", "synthase", "C0055813#ent", "<e2>", "and", "ATP", "C0055813#ent", "<e2>"], "h": {"id": "C0020404", "name": "C0020404#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0055813", "name": "C0055813#ent", "pos": [16, 17]}}
{"token": ["Inhibition", "was", "prevented", "by", "C0020404#ent", "<e1>", ",", "a", "competitive", "inhibitor", "for", "ATP", "C0055813#ent", "<e2>"], "h": {"id": "C0020404", "name": "C0020404#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0055813", "name": "C0055813#ent", "pos": [12, 13]}}
{"token": ["The", "putative", "tumor", "suppressor", "NORE1A", "(", "C3538820#ent", "<e1>", ")", "is", "a", "member", "of", "the", "C1419285#ent", "<e2>", "is", "commonly", "inactivated", "in", "human", "cancer"], "h": {"id": "C3538820", "name": "C3538820#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419285", "name": "C1419285#ent", "pos": [14, 15]}}
{"token": ["SV40-transformed", "CWSV-1", "rat", "C0669372#ent", "<e1>", "that", "are", "p53-defective", "undergo", "apoptosis", "in", "response", "to", "C0008412#ent", "<e2>", "CD", ")", "or", "TGFbeta1", ",", "which", "mediates", "CD-apoptosis", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008412", "name": "C0008412#ent", "pos": [13, 14]}}
{"token": ["C0011849#ent", "<e1>", "was", "found", "to", "have", "a", "negative", "association", "with", "C1413749#ent", "<e2>", "for", "undefined", "reasons", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413749", "name": "C1413749#ent", "pos": [10, 11]}}
{"token": ["The", "C0082529#ent", "<e1>", "C3849574#ent", "<e2>", ")", "mitogen-activated", "protein", "kinase", "inhibitor", "blocked", "IL-8", "release", ",", "implicating", "C3849574#ent", "<e2>", "as", "a", "key", "mediator", "of", "EGFR", "signaling", "."], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [3, 4]}}
{"token": ["Mitogen-activated", "and", "C0082529#ent", "<e1>", "MEK", ")", "and", "extracellular", "signal-regulated", "protein", "kinase", "C3849574#ent", "<e2>", ")", "pathways", "may", "underlie", "ethanol-induced", "neuroplasticity", "."], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "the", "TNF-alpha", "induction", "of", "antiviral", "activity", "C3540823#ent", "<e1>", "in", "cells", "is", "dependent", "upon", "the", "presence", "of", "C0907533#ent", "<e2>", "low", "levels", "of", "IFN-beta", "in", "the", "responding", "cells", "."], "h": {"id": "C3540823", "name": "C3540823#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [19, 20]}}
{"token": ["Phenylarsine", "oxide", "100", "microM", ")", "reduced", "the", "decline", "in", "tension", "in", "response", "to", "C2698414#ent", "<e1>", "but", "inhibited", "the", "contraction", "elicited", "by", "C3273437#ent", "<e2>", "and", "PDB", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [21, 22]}}
{"token": ["C0205740#ent", "<e1>", "CD", ")", "virus", "primarily", "infects", "astrocytes", "and", "causes", "a", "C0011302#ent", "<e2>", "dogs", "that", "closely", "resembles", "MS", "."], "h": {"id": "C0205740", "name": "C0205740#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011302", "name": "C0011302#ent", "pos": [11, 12]}}
{"token": ["A", "C0007684#ent", "<e1>", "considered", "persistent", "when", "C1875400#ent", "<e2>", "originating", "from", "the", "same", "quarter", "had", "identical", "AFLP", "patterns", "on", "at", "least", "3", "consecutive", "samplings", "."], "h": {"id": "C0007684", "name": "C0007684#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}}
{"token": ["C0271972#ent", "<e1>", "TRMA", ";", "MIM", "249270", ")", "is", "an", "C3899988#ent", "<e2>", "features", "that", "include", "megaloblastic", "anaemia", "mild", "thrombocytopenia", "leucopenia", ",", "sensorineural", "deafness", "diabetes", "mellitus"], "h": {"id": "C0271972", "name": "C0271972#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}}
{"token": ["C0271972#ent", "<e1>", "TRMA", ")", "is", "a", "rare", "C3899988#ent", "<e2>", ",", "characterized", "by", "megaloblastic", "anaemia", "non-autoimmune", "diabetes", "mellitus", ",", "and", "sensorineural", "hearing", "loss"], "h": {"id": "C0271972", "name": "C0271972#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}}
{"token": ["C0016034#ent", "<e1>", "a", "source", "of", "considerable", "C2364135#ent", "<e2>", "in", "a", "sizeable", "percentage", "of", "women", "between", "35", "and", "50", "years", "of", "age", "."], "h": {"id": "C0016034", "name": "C0016034#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [6, 7]}}
{"token": ["Peliosis", "C0019159#ent", "<e1>", "is", "a", "C0023895#ent", "<e2>", "characterized", "by", "the", "presence", "of", "cystic", "spaces", "fill", "of", "blood", "visible", "the", "capsule", "and", "on", "the", "cutting", "surface"], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [5, 6]}}
{"token": ["Both", "C3541394#ent", "<e1>", "were", "detected", "in", "mucosa", "but", ",", "in", "general", ",", "C1412238#ent", "<e2>", "was", "found", "in", "outer", "cell", "layers", "lining", "the", "lumen", ",", "while", "ADH1", "was", "detected", "in", "the", "inner", "cell", "layers"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412238", "name": "C1412238#ent", "pos": [12, 13]}}
{"token": ["In", "surviving", "cells", ",", "C1705952#ent", "<e1>", "activates", "NF-kappaB", ",", "induces", "expression", "of", "E-selectin", ",", "C1706544#ent", "<e2>", ",", "and", "IL-8", ",", "and", "promotes", "adhesion", "of", "leukocytes", "."], "h": {"id": "C1705952", "name": "C1705952#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [14, 15]}}
{"token": ["Three", "genes", "potentially", "encoding", "novel", "matrix", "metalloproteinases", "C3494976#ent", "<e1>", ")", "were", "identified", "by", "sequence", "similarity", "of", "C0949990#ent", "<e2>", "genome", "database", "and", "cDNAs", "for", "these", "C3494976#ent", "<e1>", "were", "cloned", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [7, 8]}}
{"token": ["C1880288#ent", "<e1>", "(", "O-desmethylvenlafaxine", ")", "is", "the", "major", "active", "metabolite", "of", "C0078569#ent", "<e2>", "."], "h": {"id": "C1880288", "name": "C1880288#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0078569", "name": "C0078569#ent", "pos": [11, 12]}}
{"token": ["C1880288#ent", "<e1>", "DVS", ")", "is", "the", "active", "metabolite", "the", "serotonin", "and", "noradrenaline", "re-uptake", "inhibitor", "C0078569#ent", "<e2>", "and", "was", "recently", "FDA", "approved", "for", "the", "treatment", "of", "MDD", "."], "h": {"id": "C1880288", "name": "C1880288#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0078569", "name": "C0078569#ent", "pos": [14, 15]}}
{"token": ["These", "include", "anti-SCF", "antibodies", ",", "antisense", "oligonucleotides", "C0003015#ent", "<e1>", "and", "inhibitors", "of", "C1332447#ent", "<e2>"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332447", "name": "C1332447#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "homologies", "were", "found", "with", "the", "alternate", "complement", "pathway", "protein", "properdin", "coat", "proteins", "C0024530#ent", "<e1>", "circumsporozoites", "and", "C1318711#ent", "<e2>"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1318711", "name": "C1318711#ent", "pos": [19, 20]}}
{"token": ["The", "force-augmenting", "effects", "of", "C0128513#ent", "<e1>", "were", "not", "abolished", "by", "pretreatment", "with", "C0021246#ent", "<e2>", "(", "10(-5)M", ")", "."], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [12, 13]}}
{"token": ["There", "is", "some", "evidence", "that", "C0242172#ent", "<e1>", "such", "as", "rheumatoid", "arthritis", "RA", ")", ",", "C0024138#ent", "<e2>", ",", "scleroderma", "or", "dermatomyositis", "may", "increase", "the", "risk", "for", "the", "development", "of", "malignancies", ",", "predominantly", "lymphoproliferative", "disorders"], "h": {"id": "C0242172", "name": "C0242172#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [14, 15]}}
{"token": ["These", "cells", "were", "arrested", "in", "C1422270#ent", "<e1>", "shortly", "after", "treatment", "with", "C0063382#ent", "<e2>", "as", "shown", "by", "flow", "microfluorimetry", "autoradiography", "."], "h": {"id": "C1422270", "name": "C1422270#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0063382", "name": "C0063382#ent", "pos": [11, 12]}}
{"token": ["The", "neuromuscular", "effects", "three", "new", "C0010464#ent", "<e1>", "atracurium", ",", "vecuronium", "and", "C0115109#ent", "<e2>", ",", "were", "investigated", "in", "surgical", "patients", "under", "balanced", "anaesthesia"], "h": {"id": "C0010464", "name": "C0010464#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0115109", "name": "C0115109#ent", "pos": [11, 12]}}
{"token": ["Future", "prospective", "studies", "needed", "to", "establish", "whether", "prophylactic", "therapy", "C0033568#ent", "<e1>", "affect", "the", "prevalence", "of", "upper", "gastrointestinal", "bleeding", "patients", "using", "C0080151#ent", "<e2>", "."], "h": {"id": "C0033568", "name": "C0033568#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [20, 21]}}
{"token": ["Here", "we", "demonstrate", "that", "C0031671#ent", "<e1>", "PLD", ")", "and", "C1333201#ent", "<e2>", "cPLA2", ")", "are", "differentially", "activated", "during", "TNF-induced", "necrosis", "or", "apoptosis", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1333201", "name": "C1333201#ent", "pos": [9, 10]}}
{"token": ["During", "spliceosome", "assembly", "splicing", "factor", "1", "C1421652#ent", "<e1>", ")", "specifically", "recognizes", "the", "intron", "branch", "point", "sequence", "(", "C1849718#ent", "<e2>", ")", "UACUAAC", "in", "the", "pre-mRNA", "transcripts", "."], "h": {"id": "C1421652", "name": "C1421652#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1849718", "name": "C1849718#ent", "pos": [17, 18]}}
{"token": ["Our", "data", "suggest", "that", "C1415508#ent", "<e1>", "serves", "as", "a", "recruiting", "factor", "for", "C0012873#ent", "<e2>", "and", "HDACs", "to", "establish", "transcriptionally", "repressive", "chromatin", "which", "is", "perhaps", "further", "stabilized", "by", "DNA", "methylation", "targeted", "loci"], "h": {"id": "C1415508", "name": "C1415508#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012873", "name": "C0012873#ent", "pos": [12, 13]}}
{"token": ["We", "have", "studied", "a", "yeast", "homolog", "the", "smallest", "subunit", "of", "chromatin", "assembly", "factor", "1", "C1422407#ent", "<e1>", ")", ",", "encoded", "by", "YMR131c", "and", "termed", "\"", "C1427468#ent", "<e2>", "\"", "."], "h": {"id": "C1422407", "name": "C1422407#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1427468", "name": "C1427468#ent", "pos": [24, 25]}}
{"token": ["C1335222#ent", "<e1>", "is", "an", "anti-apoptotic", "protein", "interacts", "with", "Bcl-2", ",", "C1332397#ent", "<e2>", ",", "Hsp70/Hsc70", ",", "Raf-1", "and", "numerous", "hormone", "or", "growth", "factor", "receptors"], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [10, 11]}}
{"token": ["Other", "members", "of", "the", "Bcl-2", "family", "C1335222#ent", "<e1>", ",", "Bak", ",", "Bax", ",", "and", "C1332397#ent", "<e2>", ")", "were", "not", "altered", "in", "expression", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [14, 15]}}
{"token": ["6-Vinylpurines", "underwent", "Cu-mediated", "cyclopropanations", "with", "C0004480#ent", "<e1>", "give", "6-[(ethoxycarbonyl)cyclopropyl]purines", "that", "were", "further", "transformed", "to", "carboxylic", "acids", "C3539945#ent", "<e2>", "and", "alcohols", "."], "h": {"id": "C0004480", "name": "C0004480#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539945", "name": "C3539945#ent", "pos": [16, 17]}}
{"token": ["Far", "Western", "analysis", "that", "the", "SH3", "domains", "C1417611#ent", "<e1>", "bound", "directly", "to", "a", "C1334332#ent", "<e2>", "70", "-", "75", "kDa", "."], "h": {"id": "C1417611", "name": "C1417611#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [13, 14]}}
{"token": ["Experimental", "C0744421#ent", "<e1>", "the", "rat", "is", "thus", "characterized", "morphologically", "by", "a", "C0238143#ent", "<e2>", "proceeds", "to", "focal", "glumerulosclerosis"], "h": {"id": "C0744421", "name": "C0744421#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0238143", "name": "C0238143#ent", "pos": [11, 12]}}
{"token": ["Unmasking", "of", "a", "recessive", "mutation", "at", "the", "C0012634#ent", "<e1>", "deletion", "of", "the", "wild", "type", "allele", "be", "the", "cause", "of", "the", "C0037277#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [20, 21]}}
{"token": ["22", "patients", "who", "had", "C0020557#ent", "<e1>", "were", "given", "900", "mg", "gemfibrozil", "or", "200", "mg", "C0033228#ent", "<e2>", "daily", "for", "6", "weeks", "."], "h": {"id": "C0020557", "name": "C0020557#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [14, 15]}}
{"token": ["Clevidipine", "is", "a", "new", "vascular", "selective", "calcium", "channel", "antagonist", "the", "C0012315#ent", "<e1>", "structurally", "related", "to", "C0015772#ent", "<e2>", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [10, 11]}, "relation": "structural_class_of", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [15, 16]}}
{"token": ["A", "high-performance", "liquid", "chromatographic", "method", "electrochemical", "detection", "been", "developed", "for", "the", "determination", "of", "six", "C0012315#ent", "<e1>", ":", "nifedipine", ",", "nimodipine", ",", "nisoldipine", ",", "nicardipine", ",", "C0015772#ent", "<e2>", "and", "lacidipine", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [14, 15]}, "relation": "structural_class_of", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [25, 26]}}
{"token": ["Combined", "administration", "of", "aspirin", "and", "C4284130#ent", "<e1>", "produced", "little", "influence", "on", "the", "antipyretic", ",", "C0728960#ent", "<e2>", "and", "anti-inflammatory", "effects", "aspirin", "in", "non-ligated", "normal", "rats", "."], "h": {"id": "C4284130", "name": "C4284130#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "demonstrate", "that", "CRP", "and", "C2699241#ent", "<e1>", "share", "histone", "as", "well", "as", "chromatin", "binding", "and", "that", "both", "C1413716#ent", "<e2>", "can", "activate", "the", "classical", "C", "pathway", "ligand", "binding"], "h": {"id": "C2699241", "name": "C2699241#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413716", "name": "C1413716#ent", "pos": [18, 19]}}
{"token": ["Several", "missense", "mutations", "the", "Kv1.1", "gene", "have", "been", "associated", "with", "C1847839#ent", "<e1>", "EA-1", ")", ",", "which", "is", "characterized", "by", "C0684219#ent", "<e2>", "episodic", "attacks", "ataxic", "gait", "spastic", "contractions", "of", "skeletal", "muscles"], "h": {"id": "C1847839", "name": "C1847839#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0684219", "name": "C0684219#ent", "pos": [19, 20]}}
{"token": ["The", "transient", "C0020551#ent", "<e1>", "of", "prematurity", "(", "C1704840#ent", "<e2>", ")", "has", "been", "seen", "as", "a", "\"", "benign", "\"", "condition", "not", "requiring", "medical", "treatment"], "h": {"id": "C0020551", "name": "C0020551#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704840", "name": "C1704840#ent", "pos": [7, 8]}}
{"token": ["Agents", "targeting", "inhibitory", "cytokines", "include", "thalidomide", ",", "lenalidomide", ",", "C0717758#ent", "<e1>", ",", "infliximab", ",", "VEGF", "receptor", "inhibitor", "PTK-787", ",", "antithymocyte", "globulin", "and", "C1541463#ent", "<e2>", ",", "a", "p38", "mitogen-activated", "protein", "kinase", "inhibitor"], "h": {"id": "C0717758", "name": "C0717758#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1541463", "name": "C1541463#ent", "pos": [22, 23]}}
{"token": ["Additional", "argatroban-exposed", "samples", "diluted", "with", "C0206141#ent", "<e1>", "had", "addition", "of", "C0002313#ent", "<e2>", "(", "0.25", "U/ml", ")", "and", "fibrinogen", "(", "150", "mg/ml", ")", "."], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002313", "name": "C0002313#ent", "pos": [10, 11]}}
{"token": ["Several", "C0072522#ent", "<e1>", "GP", ")", "IIb/IIIa", "antagonists", "Sibrafiban", ",", "Orbofiban", "and", "C0960422#ent", "<e2>", ",", "have", "been", "studied", "in", "large", "phase", "III", "trials", "each", "has", "failed", "to", "provide", "efficacy", "and", "has", "been", "associated", "with", "increased", "mortality", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0960422", "name": "C0960422#ent", "pos": [11, 12]}}
{"token": ["Presently", ",", "we", "investigate", "the", "antitumor", "activity", "the", "small-molecule", "angiogenesis", "inhibitor", "C1700874#ent", "<e1>", "(", "AG-013736", ")", "and", "its", "potential", "for", "combination", "with", "C1161438#ent", "<e2>"], "h": {"id": "C1700874", "name": "C1700874#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [22, 23]}}
{"token": ["Depletion", "of", "C1424977#ent", "<e1>", "induced", "accumulation", "of", "C1332737#ent", "<e2>", ")", "in", "both", "the", "nucleus", "and", "cytoplasm", "."], "h": {"id": "C1424977", "name": "C1424977#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [7, 8]}}
{"token": ["In", "the", "Prevention", "Trial", "SOLVD", ",", "and", "the", "Survival", "and", "C0149721#ent", "<e1>", "SAVE", ")", ",", "therapy", "with", "C0014025#ent", "<e2>", "or", "captopril", "improved", "prognosis", "among", "patients", "with", ",", "generally", ",", "asymptomatic", "left", "ventricular", "dysfunction"], "h": {"id": "C0149721", "name": "C0149721#ent", "pos": [10, 11]}, "relation": "may_be_prevented_by", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [17, 18]}}
{"token": ["C0033148#ent", "<e1>", "given", "to", "a", "patient", "for", "C0014544#ent", "<e2>", "produced", "an", "unexpected", "reduction", "in", "benign", "familial", "tremor"], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [7, 8]}}
{"token": ["The", "effect", "of", "nicotinamide", "on", "the", "conversion", "of", "C0033148#ent", "<e1>", "to", "phenobarbital", "was", "studied", "in", "mice", "and", "in", "three", "C0014544#ent", "<e2>", "patients", "."], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [19, 20]}}
{"token": ["C0939537#ent", "<e1>", "(", "Glivec", ",", "formerly", "C0906802#ent", "<e2>", ")", "is", "a", "highly", "selective", "inhibitor", "of", "the", "bcr-abl", "tyrosine", "kinase", "has", "shown", "a", "promising", "therapeutic", "activity", "chronic", "myeloid", "leukemia", "the", "first", "molecularly", "targeted", "antinoplastic", "treatment", "."], "h": {"id": "C0939537", "name": "C0939537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0906802", "name": "C0906802#ent", "pos": [6, 7]}}
{"token": ["Both", "patients", "presented", "with", "C0034362#ent", "<e1>", "of", "unknown", "origin", "and", "progressive", "C1565489#ent", "<e2>", "however", ",", "lacked", "any", "other", "pathognomic", "signs", "of", "Fabry's", "disease", "as", "acroparesthesias", ",", "dyshidrosis", ",", "and", "cutaneous", "angiokeratomas"], "h": {"id": "C0034362", "name": "C0034362#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [11, 12]}}
{"token": ["Neither", "SKF", "38393", "(", "a", "D1/D5", "agonist", ")", "nor", "quinpirole", "(", "a", "D2/D3", "C0243192#ent", "<e1>", ")", "had", "any", "effect", "on", "whole-terminal", "C1416378#ent", "<e2>", "in", "this", "preparation", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416378", "name": "C1416378#ent", "pos": [21, 22]}}
{"token": ["The", "rank", "order", "of", "C0243192#ent", "<e1>", "potency", "in", "enhancing", "C1416378#ent", "<e2>", "was", "2-methylthio-ATP>/=", "ATP>>alpha", ",", "beta-methylene-ATP", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416378", "name": "C1416378#ent", "pos": [9, 10]}}
{"token": ["These", "genes", "encode", "proteins", "that", "regulate", "DNA", "methylation", "C2697959#ent", "<e1>", ")", ",", "modify", "histones", "(", "RSK2", "and", "C1539790#ent", "<e2>", ")", ",", "and", "remodel", "nucleosomes", "through", "ATP", "hydrolysis", "(", "ATRX", ")", "."], "h": {"id": "C2697959", "name": "C2697959#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539790", "name": "C1539790#ent", "pos": [17, 18]}}
{"token": ["The", "localization", "of", "5", "alpha-reductase", "within", "the", "nuclear", "envelope", "rat", "ventral", "prostate", "an", "C1823138#ent", "<e1>", "to", "be", "of", "physiological", "significance", "regard", "to", "the", "action", "of", "C0002842#ent", "<e2>", "."], "h": {"id": "C1823138", "name": "C1823138#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [25, 26]}}
{"token": ["Total", "carnitine", "palmitoyltransferase", "enzyme", "system", "CPT", ")", "activity", "was", "normal", "but", "abnormally", "inhibited", "by", "malonyl-CoA", ",", "C3710848#ent", "<e1>", ",", "and", "the", "detergents", "Triton", "X", "C0041420#ent", "<e2>", "20", "."], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0041420", "name": "C0041420#ent", "pos": [24, 25]}}
{"token": ["This", "is", "considerably", "lower", "than", "that", "of", "other", "initiation", "factors", "suggests", "that", "C3887980#ent", "<e1>", "may", "be", "the", "limiting", "C1305923#ent", "<e2>", "in", "the", "initiation", "of", "protein", "synthesis"], "h": {"id": "C3887980", "name": "C3887980#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [18, 19]}}
{"token": ["After", "LPS", "challenge", ",", "C1333257#ent", "<e1>", "knockout", "mice", "dramatically", "more", "C0812246#ent", "<e2>", ",", "IL-6", ",", "and", "IL-10", "than", "do", "wild-type", "mice"], "h": {"id": "C1333257", "name": "C1333257#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [10, 11]}}
{"token": ["We", "demonstrate", "that", "upon", "LPS", "challenge", ",", "C1333257#ent", "<e1>", "prolonged", "p38", "and", "c-Jun", "NH2-terminal", "kinase", "activation", "well", "as", "enhanced", "C0812246#ent", "<e2>", "and", "interleukin", "(IL)-6", "production", "compared", "with", "wild-type", "cells", "."], "h": {"id": "C1333257", "name": "C1333257#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [19, 20]}}
{"token": ["Ketoconazole", "(", "C1422009#ent", "<e1>", ")", "is", "frequently", "used", "as", "a", "C0010592#ent", "<e2>", "(CyA)-sparing", "agent", "."], "h": {"id": "C1422009", "name": "C1422009#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [10, 11]}}
{"token": ["A", "number", "of", "polypeptide", "hormones", "including", "human", "C1413752#ent", "<e1>", "hPRL", "and", "rat", "GH", ",", "did", "not", "inhibit", "C1337049#ent", "<e2>", "binding", "."], "h": {"id": "C1413752", "name": "C1413752#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337049", "name": "C1337049#ent", "pos": [17, 18]}}
{"token": ["The", "question", "arose", "as", "to", "whether", "the", "normal", "negative", "feedback", "regulation", "of", "the", "concentration", "of", "C0812443#ent", "<e1>", "(", "TPO", ")", "in", "blood", "was", "altered", "in", "C0022104#ent", "<e2>", "patients", "."], "h": {"id": "C0812443", "name": "C0812443#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [25, 26]}}
{"token": ["Copy", "C0011522#ent", "<e1>", "corresponding", "to", "a", "highly", "repetitive", ",", "C3275254#ent", "<e2>", "maize", "have", "been", "cloned", "by", "differential", "screening", "a", "coleoptile", "cDNA", "library"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3275254", "name": "C3275254#ent", "pos": [9, 10]}}
{"token": ["C2987364#ent", "<e1>", "and", "several", "mutant", "human", "manganese", "C0038838#ent", "<e2>", "Mn-SODs", ")", "were", "produced", "in", "a", "baculovirus/insect", "cell", "system", "and", "characterized", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [7, 8]}}
{"token": ["Although", "large", "amounts", "of", "C2987364#ent", "<e1>", "human", "Cu", ",", "C0038838#ent", "<e2>", "SOD", ")", "are", "easily", "expressed", "in", "Escherichia", "coli", "the", "amyotrophic", "lateral", "mutants", "have", "a", "strong", "propensity", "to", "aggregate", "into", "inclusion", "bodies"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [9, 10]}}
{"token": ["They", "consisted", "of", "behavioural", "disorders", "C0575059#ent", "<e1>", ",", "incontinence", "and", "C0029089#ent", "<e2>"], "h": {"id": "C0575059", "name": "C0575059#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029089", "name": "C0029089#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "one", "can", "isolate", "drug-resistant", "virus", "carrying", "mutations", "in", "the", "C0032467#ent", "<e1>", "yet", "the", "C0023689#ent", "<e2>", "is", "not", "known", "to", "exhibit", "sensitivity", "to", "these", "drugs", "."], "h": {"id": "C0032467", "name": "C0032467#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0023689", "name": "C0023689#ent", "pos": [15, 16]}}
{"token": ["Pauciarticular", "onset", "C3714757#ent", "<e1>", "was", "present", "in", "46", "%", ",", "polyarticular", "onset", "C3714757#ent", "<e1>", "in", "35", "%", ",", "and", "C0087031#ent", "<e1>", "C3714757#ent", "<e1>", "in", "19", "%", "of", "the", "children", "."], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0087031", "name": "C0087031#ent", "pos": [19, 20]}}
{"token": ["CLN2", "is", "grouped", "in", "Eubacteria", ",", "C0268281#ent", "<e1>", "and", "CLN10", "in", "Viridiplantae", ",", "C0751383#ent", "<e2>", "in", "Fungi/", "Metazoa", "CLN7", "in", "Bilateria", "and", "CLN5", ",", "CLN6", "and", "CLN8", "in", "Euteleostomi", "."], "h": {"id": "C0268281", "name": "C0268281#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751383", "name": "C0751383#ent", "pos": [13, 14]}}
{"token": ["This", "tyrosine", "residue", "its", "C0815040#ent", "<e1>", "conserved", "throughout", "the", "family", "members", "including", "radixin", ",", "C0128818#ent", "<e2>", ",", "and", "the", "two", "phosphotyrosine", "phosphatases", "PTP", "H1", "PTP", "MEG", ",", "but", "not", "in", "band", "4.1", "or", "talin", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0128818", "name": "C0128818#ent", "pos": [14, 15]}}
{"token": ["Carpal", "tunnel", "syndrome", "CTS", ")", "is", "known", "as", "a", "C0035127#ent", "<e1>", "but", "the", "role", "of", "other", "C0012634#ent", "<e2>", "in", "the", "development", "or", "prognosis", "of", "CTS", "is", "uncertain", "."], "h": {"id": "C0035127", "name": "C0035127#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "the", "increment", "of", "C1412228#ent", "<e1>", "gene", "expression", "to", "nicotine", "treatment", "might", "be", "involved", "in", "the", "C0242912#ent", "<e2>", "by", "nicotine", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [19, 20]}}
{"token": ["Hence", ",", "using", "this", "model", ",", "we", "systematically", "investigated", "the", "potential", "roles", "of", "C3273437#ent", "<e1>", "and", "NO", "in", "the", "pathogenesis", "of", "the", "various", "C0042075#ent", "<e2>", "associated", "with", "BOO", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [23, 24]}}
{"token": ["Sulfasalazine", "and", "topical", "corticosteroids", "i.e.", ",", "hydrocortisone", ",", "hydrocortisone", "acetate", "C0600901#ent", "<e1>", "are", "effective", "in", "many", "patients", "with", "C0009324#ent", "<e2>"], "h": {"id": "C0600901", "name": "C0600901#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [18, 19]}}
{"token": ["The", "C0085536#ent", "<e1>", "vanadate", ",", "in", "turn", ",", "prevented", "the", "C1705845#ent", "<e2>", "mediated", "effects", "on", "superoxide", "formation"], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705845", "name": "C1705845#ent", "pos": [10, 11]}}
{"token": ["The", "C4083008#ent", "<e1>", "detection", "was", "performed", "with", "the", "sequence", "coding", "surface", "immunogenic", "protein", "from", "C4083008#ent", "<e1>", "human", "isolates", "designated", "as", "Sip", "specific", "sequence", "C0723181#ent", "<e1>", ")", ";", "this", "sequence", "was", "selected", "for", "specific", "primer", "design"], "h": {"id": "C4083008", "name": "C4083008#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0723181", "name": "C0723181#ent", "pos": [23, 24]}}
{"token": ["All", "the", "C1875400#ent", "<e1>", "were", "susceptible", "to", "C0071972#ent", "<e2>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0071972", "name": "C0071972#ent", "pos": [7, 8]}}
{"token": ["The", "most", "frequent", "indications", "for", "laparoscopy", "were", "lower", "C0000737#ent", "<e1>", "unknown", "etiology", ",", "C0001577#ent", "<e2>", ",", "and", "adnexal", "tumors"], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001577", "name": "C0001577#ent", "pos": [13, 14]}}
{"token": ["To", "investigate", "the", "relationship", "of", "apolipoprotein", "E", "C1412481#ent", "<e1>", ")", "genotype", ",", "plasma", "levels", "C1412481#ent", "<e1>", "and", "lipids", "in", "temporal", "lobe", "epilepsy", "C0014556#ent", "<e1>", ")", "patients", "in", "Asian", "Indians"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [22, 23]}}
{"token": ["This", "study", "examined", "the", "relationship", "between", "the", "C1412481#ent", "<e1>", "epsilon4", "allele", "postictal", "confusion", "patients", "with", "medically", "intractable", "C0014556#ent", "<e2>", "TLE", ")", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [17, 18]}}
{"token": ["Water-in-oil", "emulsions", "are", "commonly", "amended", "with", "immune", "stimulants", "as", "Mycobacteria", "(", "e.g.", ",", "Freund", "complete", "adjuvant", "C0343068#ent", "<e1>", ")", "to", "increase", "antibody", "production", "to", "soluble", "protein", "antigens", "C1420002#ent", "<e2>", ")", "."], "h": {"id": "C0343068", "name": "C0343068#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [27, 28]}}
{"token": ["was", "administered", "in", "addition", "to", "C0008783#ent", "<e1>", "and", "mepyramine", ",", "C0151744#ent", "<e2>", "LV", "contractile", "failure", "were", "markedly", "inhibited", "further", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [10, 11]}}
{"token": ["C0678133#ent", "<e1>", "binds", "to", "the", "cellular", "microtubules", "suppresses", "their", "C0948268#ent", "<e2>"], "h": {"id": "C0678133", "name": "C0678133#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0948268", "name": "C0948268#ent", "pos": [9, 10]}}
{"token": ["To", "evaluate", "the", "usage", "of", "glucocorticoid", "(", "C3537453#ent", "<e1>", ")", "in", "treatment", "for", "patients", "with", "C0035220#ent", "<e2>", "ARDS", ")", "resulting", "from", "serious", "community-acquired", "pneumonia", "SCAP", ")", "."], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [15, 16]}}
{"token": ["The", "ADH3", "gene", "encodes", "alcohol", "dehydrogenase", "3", "C0254269#ent", "<e1>", "the", "ancestral", "and", "most", "conserved", "form", "of", "C3659502#ent", "<e2>"], "h": {"id": "C0254269", "name": "C0254269#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [16, 17]}}
{"token": ["The", "human", "C0254269#ent", "<e1>", "ADH5", ")", "differs", "from", "all", "other", "human", "C3659502#ent", "<e2>", "its", "ubiquitous", "expression", ",", "although", "there", "are", "tissue-specific", "differences", "the", "level", "of", "expression", "."], "h": {"id": "C0254269", "name": "C0254269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [11, 12]}}
{"token": ["Amiodarone", "is", "a", "potent", "and", "efficacious", "C2979921#ent", "<e1>", "yet", "associated", "with", "use", "are", "life-threatening", "C0034069#ent", "<e2>", "hepatotoxicity", "."], "h": {"id": "C2979921", "name": "C2979921#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [14, 15]}}
{"token": ["The", "boy", "is", "quite", "healthy", "and", "C0014544#ent", "<e1>", "is", "under", "control", "of", "C0109002#ent", "<e2>", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0109002", "name": "C0109002#ent", "pos": [12, 13]}}
{"token": ["We", "present", "a", "case", "whose", "clinical", "diagnosis", "initially", "confounded", "by", "the", "mildness", "of", "the", "C0751837#ent", "<e1>", "phenotype", "and", "a", "family", "history", "C1417325#ent", "<e2>"], "h": {"id": "C0751837", "name": "C0751837#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [21, 22]}}
{"token": ["These", "results", "indicate", "that", "C0242901#ent", "<e1>", "neurons", "contribute", "to", "the", "C3543842#ent", "<e2>", "regulation", "of", "nociceptive", "input", "at", "the", "spinal", "cord"], "h": {"id": "C0242901", "name": "C0242901#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [10, 11]}}
{"token": ["The", "coiled-coil", "domain", "dystrophia", "myotonica", "protein", "kinase", "C0216045#ent", "<e1>", ")", "has", "been", "cloned", ",", "C3889446#ent", "<e2>", ",", "purified", "and", "crystallized", "."], "h": {"id": "C0216045", "name": "C0216045#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [14, 15]}}
{"token": ["To", "address", "this", ",", "we", "investigated", "the", "cost-effectiveness", "of", "aCGH", "versus", "standard", "cytogenetic", "analysis", "diagnosing", "idiopathic", "learning", "disability", "C0206062#ent", "<e1>", ")", "in", "the", "C1417725#ent", "<e2>", "."], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417725", "name": "C1417725#ent", "pos": [23, 24]}}
{"token": ["A", "40", "per", "cent", "decrease", "in", "erythrocyte", "C0038838#ent", "<e1>", "activity", "occurred", "in", "sheep", "C0342895#ent", "<e2>", "diets", "supplemented", "with", "molybdenum", "and", "sulphate", "for", "90", "days", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [13, 14]}}
{"token": ["Decreased", "palmitoleate", "concentrations", "suggest", "inhibition", "of", "the", "C0038233#ent", "<e1>", "but", "normal", "C0220884#ent", "<e2>", "concentrations", "complicate", "this", "interpretation", "."], "h": {"id": "C0038233", "name": "C0038233#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0220884", "name": "C0220884#ent", "pos": [11, 12]}}
{"token": ["Thirty-three", "polymerase", "chain", "reaction", "products", "identified", "as", "PTP", "related", "complementary", "C0011522#ent", "<e1>", ",", "were", "classified", "to", "RPTP-alpha", ",", "C1709439#ent", "<e2>", ",", "and", "4", "novel", "PTPs", ",", "which", "were", "designated", "as", "BPTP-1", "-", "4", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1709439", "name": "C1709439#ent", "pos": [18, 19]}}
{"token": ["The", "beneficial", "effects", "of", "macrophage-targeted", "glucocerebrosidase", "(", "C0102139#ent", "<e1>", ",", "Ceredase", ")", "in", "patients", "with", "C0017205#ent", "<e2>", "well", "established", "."], "h": {"id": "C0102139", "name": "C0102139#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0017205", "name": "C0017205#ent", "pos": [15, 16]}}
{"token": ["RNase", "L", "C1414444#ent", "<e1>", "are", "members", "of", "a", "superfamily", "of", "regulated", "C1333398#ent", "<e2>", "that", "play", "essential", "roles", "in", "mediating", "diverse", "types", "of", "cellular", "stress", "responses"], "h": {"id": "C1414444", "name": "C1414444#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333398", "name": "C1333398#ent", "pos": [11, 12]}}
{"token": ["C0128513#ent", "<e1>", "shortened", "the", "onset", ",", "prolonged", "the", "C2926735#ent", "<e2>", "and", "degree", "of", "pulmonary", "vasodilation", "by", "PGI(2)"], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [8, 9]}}
{"token": ["Both", "C0128513#ent", "<e1>", "and", "saterinone", "increased", "the", "amplitude", ",", "depolarization", "velocity", "and", "C2926735#ent", "<e2>", "of", "slow", "response", "action", "potentials", "in", "K+-depolarized", "muscles", "."], "h": {"id": "C0128513", "name": "C0128513#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [12, 13]}}
{"token": ["In", "terms", "of", "dynamical", "system", "theory", "rapid", "alteration", "of", "electromagnetic", "brain", "signal", "properties", "observed", "with", "transition", "from", "interictal", "into", "ictal", "C0014544#ent", "<e1>", "an", "alteration", "between", "at", "least", "two", "dynamical", "states", "C1412696#ent", "<e2>", ")", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1412696", "name": "C1412696#ent", "pos": [30, 31]}}
{"token": ["Lipolytic", "activity", "was", "enhanced", "3-", "to", "4-fold", "in", "the", "presence", "of", "C0009304#ent", "<e1>", ",", "an", "effect", "which", "is", "attributed", "to", "increased", "C0014442#ent", "<e2>", "turnover", "number", "."], "h": {"id": "C0009304", "name": "C0009304#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["A", "C0041983#ent", "<e1>", "be", "useful", "for", "patients", "with", "hypertension", "who", "also", "have", "C0041983#ent", "<e1>", "due", "to", "a", "low", "excretion", "of", "uric", "acid"], "h": {"id": "C0041983", "name": "C0041983#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041983", "name": "C0041983#ent", "pos": [1, 2]}}
{"token": ["Treatment", "of", "human", "mesenchymal", "stem", "cells", "C0215737#ent", "<e1>", "suppressed", "expression", "of", "C0377148#ent", "<e2>", "BMP-2", ")", "."], "h": {"id": "C0215737", "name": "C0215737#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [11, 12]}}
{"token": ["Upon", "the", "activation", "of", "C0659150#ent", "<e1>", ",", "the", "Ser1131", "within", "the", "C-terminal", "region", "C0172870#ent", "<e2>", "is", "phosphorylated", ",", "and", "this", "phosphorylation", "is", "critical", "for", "the", "checkpoint", "response"], "h": {"id": "C0659150", "name": "C0659150#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0172870", "name": "C0172870#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "show", "that", "genotoxin-induced", "C0659150#ent", "<e1>", "activation", "requires", "C0172870#ent", "<e2>", "(", "Mus101/TopBP1", ")", "in", "a", "process", "that", "is", "independent", "of", "the", "role", "of", "C0172870#ent", "<e2>", "in", "DNA", "replication"], "h": {"id": "C0659150", "name": "C0659150#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0172870", "name": "C0172870#ent", "pos": [9, 10]}}
{"token": ["The", "Oculo-cerebro-renal", "syndrome", "C0028860#ent", "<e1>", "is", "an", "X-linked", "recessive", "disorder", "by", "mental", "and", "growth", "retardation", "C1527410#ent", "<e2>", "renal", "tubular", "acidosis", "generalised", "aminoaciduria", "hypotonia", ",", "cataracts", ",", "glaucoma", "and", "frontal", "bossing"], "h": {"id": "C0028860", "name": "C0028860#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C1527410", "name": "C1527410#ent", "pos": [15, 16]}}
{"token": ["Murine", "endothelial", "nitric", "oxide", "synthase", "C1328053#ent", "<e1>", ")", "is", "encoded", "by", "C3539709#ent", "<e2>", ",", "located", "on", "mouse", "chromosome", "5"], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539709", "name": "C3539709#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "the", "p38", "MAP", "kinase", "pathway", "modulates", "the", "C4255305#ent", "<e1>", "action", "of", "ANG", "II", "C1412137#ent", "<e2>"], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [17, 18]}}
{"token": ["Taking", "these", "effects", "into", "account", ",", "C0023863#ent", "<e1>", "is", "considerably", "more", "active", "as", "an", "anticonvulsant", "than", "C0072892#ent", "<e2>", "."], "h": {"id": "C0023863", "name": "C0023863#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072892", "name": "C0072892#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "the", "relationship", "between", "cardiovascular", "autonomic", "nervous", "system", "function", "carotid", "arterial", "distensibility", "during", "treatment", "with", "an", "angiotensin", "converting", "enzyme", "inhibitor", "C0057301#ent", "<e1>", ")", "or", "a", "C0006684#ent", "<e2>", "manidipine", ")", "for", "hypertension", "."], "h": {"id": "C0057301", "name": "C0057301#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [26, 27]}}
{"token": ["C3887547#ent", "<e1>", "common", "in", "patients", "with", "C2316810#ent", "<e2>"], "h": {"id": "C3887547", "name": "C3887547#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [6, 7]}}
{"token": ["A", "patient", "is", "presented", "with", "a", "prominent", "C0162359#ent", "<e1>", "a", "chronic", "mucocutaneous", "candidiasis", "were", "due", "to", "the", "underlying", "C0342342#ent", "<e2>"], "h": {"id": "C0162359", "name": "C0162359#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342342", "name": "C0342342#ent", "pos": [18, 19]}}
{"token": ["C1334905#ent", "<e1>", "is", "a", "glycoprotein", "homologous", "to", "the", "C1413716#ent", "<e2>", "of", "the", "acute", "phase", "response", ",", "and", "it", "is", "involved", "in", "both", "synaptogenesis", "and", "synaptic", "remodeling"], "h": {"id": "C1334905", "name": "C1334905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413716", "name": "C1413716#ent", "pos": [8, 9]}}
{"token": ["Ubiquitination", "of", "C1416958#ent", "<e1>", "by", "c-IAP1", "accelerates", "its", "degradation", "by", "the", "26S", "proteasome", "pathway", "and", "this", "reduction", "of", "the", "C1416958#ent", "<e1>", "levels", "cooperates", "with", "C0086661#ent", "<e1>", "to", "promote", "cell", "proliferation"], "h": {"id": "C1416958", "name": "C1416958#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [24, 25]}}
{"token": ["The", "growth", "inhibition", "by", "C1416958#ent", "<e1>", "is", "overcome", "by", "expression", "of", "active", "C0086661#ent", "<e2>", "."], "h": {"id": "C1416958", "name": "C1416958#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [12, 13]}}
{"token": ["Terminal", "differentiation", "of", "human", "monocytic", "leukemia", "cells", "THP-1", "cells", ")", "was", "associated", "with", "induction", "of", "C1706383#ent", "<e1>", ",", "the", "down", "regulation", "of", "C0026900#ent", "<e2>", ",", "and", "no", "significant", "in", "the", "level", "of", "c-myc", "expression", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026900", "name": "C0026900#ent", "pos": [22, 23]}}
{"token": ["C0162429#ent", "<e1>", "not", "alter", "the", "magnitude", "and", "time", "course", "the", "C1704793#ent", "<e2>", "response", "to", "a", "1-min", "exposure", "to", "novel", "chamber", "alone", "or", "with", "ether", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [10, 11]}}
{"token": ["Nephrogenic", "fibrosing", "dermopathy", "a", "rare", ",", "C0036412#ent", "<e1>", "patients", "with", "renal", "failure", "which", "may", "be", "mistaken", "for", "C0263390#ent", "<e2>", "."], "h": {"id": "C0036412", "name": "C0036412#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0263390", "name": "C0263390#ent", "pos": [17, 18]}}
{"token": ["We", "propose", "that", "the", "direct", "interaction", "of", "C1425322#ent", "<e1>", "and", "hnRNP", "K", "affect", "the", "activities", "of", "both", "C0086376#ent", "<e2>", "in", "signal", "transduction", "pathways", "both", "transcriptional", "and", "post-transcriptional", "events"], "h": {"id": "C1425322", "name": "C1425322#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}}
{"token": ["C1425322#ent", "<e1>", "contains", "consensus", "sequences", "interact", "with", "other", "C0086376#ent", "<e2>", "via", "specific", "domains", "."], "h": {"id": "C1425322", "name": "C1425322#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["Additionally", ",", "plasma", "corticosterone", ",", "but", "not", "epinephrine", "and", "C3887648#ent", "<e1>", ",", "concentrations", "were", "elevated", "in", "response", "to", "AVP", "and", "C1418208#ent", "<e2>", "infusions", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418208", "name": "C1418208#ent", "pos": [20, 21]}}
{"token": ["Transmembrane", "(", "e.g.", "EGFR", ",", "C1705320#ent", "<e1>", ")", "or", "cytoplasmic", "(", "Src", ",", "C1826328#ent", "<e2>", ")", "tyrosine", "kinases", "found", "mutated", "in", "a", "variety", "of", "human", "tumors", "."], "h": {"id": "C1705320", "name": "C1705320#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826328", "name": "C1826328#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "provide", "evidence", "for", "novel", "activity", "of", "C1332408#ent", "<e1>", "in", "cell", "cycle", "control", "point", "toward", "an", "C0812287#ent", "<e2>", "sensitization", "to", "cell", "death", "the", "nervous", "system", "is", "under", "the", "control", "of", "NT-3", "."], "h": {"id": "C1332408", "name": "C1332408#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812287", "name": "C0812287#ent", "pos": [17, 18]}}
{"token": ["Isolated", "cases", "of", "hereditary", "motor", "sensory", "neuropathy", "type", "I", "HMSN", "I", "C1843247#ent", "<e1>", "have", "been", "thought", "to", "be", "most", "frequently", "C3899988#ent", "<e2>"], "h": {"id": "C1843247", "name": "C1843247#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [20, 21]}}
{"token": ["By", "linkage", "analysis", "two", "C1418845#ent", "<e1>", "families", "the", "C1704801#ent", "<e2>", "locus", "could", "be", "conclusively", "excluded", "."], "h": {"id": "C1418845", "name": "C1418845#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704801", "name": "C1704801#ent", "pos": [8, 9]}}
{"token": ["Serotonin", "syndrome", "with", "selective", "C0162758#ent", "<e1>", "opioids", ",", "and", "other", "C0036753#ent", "<e2>"], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036753", "name": "C0036753#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "we", "used", "sertraline", "as", "a", "C0162758#ent", "<e1>", "cyproheptadine", "as", "a", "C0036753#ent", "<e2>"], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036753", "name": "C0036753#ent", "pos": [13, 14]}}
{"token": ["The", "antiproliferative", "effect", "of", "C0162758#ent", "<e1>", "SSRI", ")", "and", "C0036753#ent", "<e2>", "been", "demonstrated", "in", "prostate", "tumors"], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036753", "name": "C0036753#ent", "pos": [9, 10]}}
{"token": ["Presenting", "symptoms", "being", "indistinguishable", "from", "other", "causes", "of", "C0348165#ent", "<e1>", "all", "patients", "with", "a", "clinical", "diagnosis", "C0025289#ent", "<e2>", ",", "irrespective", "of", "their", "immune", "status", "be", "investigated", "for", "cryptococcal", "infection"], "h": {"id": "C0348165", "name": "C0348165#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [16, 17]}}
{"token": ["Whereas", "C0348165#ent", "<e1>", "humans", "is", "typically", "C0025289#ent", "<e2>", ",", "brain", "disease", "dogs", "and", "cats", "takes", "the", "form", "of", "granulomatous", "parenchymal", "masses", "."], "h": {"id": "C0348165", "name": "C0348165#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [6, 7]}}
{"token": ["Sweet's", "syndrome", "or", "acute", "febrile", "neutrophilic", "dermatosis", "is", "a", "rare", "C0029400#ent", "<e1>", "is", "characterized", "by", "fever", ",", "neutrophilia", ",", "and", "C0239377#ent", "<e2>", "erythematous", "plaques", "that", "histologically", "show", "a", "dense", "dermal", "infiltrate", "neutrophils", "without", "associated", "vasculitis", "."], "h": {"id": "C0029400", "name": "C0029400#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [20, 21]}}
{"token": ["The", "patient", "was", "found", "to", "be", "suffering", "from", "C0002876#ent", "<e1>", "CDA", ")", "type", "III", ",", "a", "rare", "form", "of", "C0158995#ent", "<e2>", "inherited", "as", "an", "autosomal", "dominant", "in", "some", "families", "."], "h": {"id": "C0002876", "name": "C0002876#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0158995", "name": "C0158995#ent", "pos": [19, 20]}}
{"token": ["The", "genuine", "interactions", "between", "H2AX", "and", "H2B", ",", "C0069141#ent", "<e1>", ",", "calreticulin", ",", "poly(ADP-ribose)", "polymerase-1", "and", "C1861821#ent", "<e2>", "under", "each", "condition", "were", "validated", "by", "immunoprecipitation/Western", "blotting", "and", "mammalian", "two-hybrid", "assays"], "h": {"id": "C0069141", "name": "C0069141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1861821", "name": "C1861821#ent", "pos": [16, 17]}}
{"token": ["Anthraquinone", "and", "C0003174#ent", "<e1>", "methyl", "groups", "the", "A", "ring", "showed", "higher", "C0003308#ent", "<e2>", "the", "unsubstituted", "ones", ",", "4,4,6,7-tetramethyl-(4H)-anthracene-1,9,10-trione", "being", "the", "most", "active", "compound", "this", "set", "."], "h": {"id": "C0003174", "name": "C0003174#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", ",", "the", "impact", "of", "aerosolised", "prostacyclin", "PGI2", ")", "and", "iloprost", "in", "the", "absence", "or", "presence", "of", "subthreshold", "intravascular", "doses", "the", "dual-selective", "phosphodiesterase-3/4", "inhibitor", "C0085049#ent", "<e1>", "was", "investigated", "in", "an", "experimental", "model", "C0264490#ent", "<e2>"], "h": {"id": "C0085049", "name": "C0085049#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [34, 35]}}
{"token": ["B", "lymphocytes", "patients", "with", "C0020725#ent", "<e1>", "ICD", ")", "maintain", "normal", "cellular", "levels", "C0391845#ent", "<e2>", "a", "deficiency", "of", "the", "enzyme", "UDP-N-acetylglucosamine", "lysosomal", "enzyme", "N-acetylglucosamine-1-phosphotransferase"], "h": {"id": "C0020725", "name": "C0020725#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [12, 13]}}
{"token": ["C0020725#ent", "<e1>", "characterised", "by", "loss", "of", "C0391845#ent", "<e2>", "fibroblasts", "with", "accumulation", "of", "the", "same", "enzymes", "in", "the", "surrounding", "fluid", "."], "h": {"id": "C0020725", "name": "C0020725#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0391845", "name": "C0391845#ent", "pos": [6, 7]}}
{"token": ["Both", "IgM", "and", "IgD", "signaling", "lead", "to", "modulation", "of", "phosphatidylinositol", "3-kinase", "C0044602#ent", "<e1>", "signals", ",", "including", "the", "activation", "of", "C1335645#ent", "<e2>", ",", "but", "this", "pathway", "recovers", "under", "anti-IgD", "treatment", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335645", "name": "C1335645#ent", "pos": [19, 20]}}
{"token": ["C0991617#ent", "<e1>", "known", "to", "inhibit", "transglutaminase-mediated", "protein", "cross-linking-putrescine", ",", "C0021974#ent", "<e2>", ",", "and", "ethylene", "glycol-bis(beta-aminoethyl", "ether)N", ",", "N", ",", "N',N'-tetraacetate", "(EGTA)-", "also", "prevent", "envelope", "formation"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021974", "name": "C0021974#ent", "pos": [9, 10]}}
{"token": ["This", "and", "other", "features", "of", "C3890176#ent", "<e1>", "lesions", "indicate", "that", "down-regulation", "of", "C3538961#ent", "<e2>", "expression", "might", "cause", "aberrant", "retinoid-regulated", "gene", "expression", "in", "skin", "."], "h": {"id": "C3890176", "name": "C3890176#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538961", "name": "C3538961#ent", "pos": [12, 13]}}
{"token": ["Excessive", "monoclonal", "light", "chain", "and", "excretion", "may", "result", "in", "a", "variety", "of", "C0022658#ent", "<e1>", "may", "collectively", "or", "individually", "be", "referred", "to", "as", "C0022658#ent", "<e1>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [12, 13]}}
{"token": ["The", "general", "C0002932#ent", "<e1>", "ketamine", "were", "unaffected", "by", "C0005372#ent", "<e2>", ";", "antagonism", "was", "seen", "with", "4-aminopyridine", "and", "significant", "potentiation", "with", "300", "mg", "kg(-1", ")", "NMDLA", "(", "N-methyl-DL-aspartate", ")", "."], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005372", "name": "C0005372#ent", "pos": [8, 9]}}
{"token": ["With", "the", "exception", "of", "ketamine", ",", "the", "IC(50", ")", "values", "for", "these", "C0002932#ent", "<e1>", "increased", "threefold", "by", "C0005372#ent", "<e2>", "(", "100", "microM", ")", "."], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0005372", "name": "C0005372#ent", "pos": [17, 18]}}
{"token": ["The", "relative", "activity", "of", "a", "series", "of", "compounds", "to", "enhance", "GABA", "binding", "correlates", "significantly", "with", "their", "C0002932#ent", "<e1>", "with", "their", "ability", "to", "C0005372#ent", "<e2>", "antagonism", "of", "GABA", "responses", "."], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0005372", "name": "C0005372#ent", "pos": [22, 23]}}
{"token": ["The", "mutations", "were", "made", "in", "wild-type", "crp", "as", "well", "as", "a", "cAMP-independent", "crp", ",", "crp*.", "The", "activities", "of", "the", "C1564140#ent", "<e1>", "characterized", "in", "vivo", "their", "ability", "to", "activate", "the", "C0029073#ent", "<e2>"], "h": {"id": "C1564140", "name": "C1564140#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [29, 30]}}
{"token": ["The", "C1413247#ent", "<e1>", "may", "be", "reduced", "by", "C0026769#ent", "<e2>", "lesions", "and", "by", "excessive", "attention-draining", "demands", "imposed", "by", "the", "disease", "."], "h": {"id": "C1413247", "name": "C1413247#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [7, 8]}}
{"token": ["When", "the", "heart", "was", "reperfused", ",", "the", "normal", "elevation", "of", "2,3-DHBA", "in", "the", "C0011947#ent", "<e1>", "not", "observed", "in", "animals", "pretreated", "with", "C0017628#ent", "<e2>", "(", "10microM", ")", "or", "5-HD", "(", "100microM", ")", "."], "h": {"id": "C0011947", "name": "C0011947#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [21, 22]}}
{"token": ["When", "the", "heart", "was", "reperfused", ",", "the", "normal", "elevation", "of", "2,3-DHBA", "in", "the", "C0011947#ent", "<e1>", "not", "observed", "in", "animals", "pretreated", "with", "C0017628#ent", "<e2>", "(", "10", "microM", ")", "."], "h": {"id": "C0011947", "name": "C0011947#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [21, 22]}}
{"token": ["Binding", "of", "125I-kallikrein", "to", "kallikrein-binding", "protein", "temperature-dependent", "and", "can", "be", "inhibited", "by", "heparin", "or", "excess", "unlabelled", "C1416669#ent", "<e1>", "not", "by", "plasma", "kallikrein", "C0962754#ent", "<e2>", ",", "thrombin", ",", "urokinase", ",", "alpha", "1-antitrypsin", "kininogens", "."], "h": {"id": "C1416669", "name": "C1416669#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [22, 23]}}
{"token": ["3", ")", "The", "bipolar", "C0166027#ent", "<e1>", "expression", "occurred", "during", "the", "gradual", ",", "linear", "inhibition", "C0257535#ent", "<e2>", "both", "inhibitors", ",", "SB203580", "and", "p38DN", "."], "h": {"id": "C0166027", "name": "C0166027#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [14, 15]}}
{"token": ["PKB/Akt", ",", "C2827382#ent", "<e1>", "and", "SGK", "are", "related", "C0030940#ent", "<e2>", "activated", "in", "a", "PI", "3-kinase-dependent", "manner", "in", "response", "to", "insulin/growth", "factors", "signalling", "."], "h": {"id": "C2827382", "name": "C2827382#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "mRNAs", "of", "ACT", "(", "activator", "of", "C1413706#ent", "<e1>", "in", "testis", ")", "and", "C1413706#ent", "<e1>", "target", "C1417679#ent", "<e1>", "are", "downregulated", "in", "miwi(null", ")", "testes", "."], "h": {"id": "C1413706", "name": "C1413706#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}}
{"token": ["C1413706#ent", "<e1>", "regulates", "many", "crucial", "C1417679#ent", "<e2>", "required", "for", "spermatid", "maturation", "and", "targeted", "mutation", "of", "the", "Crem", "gene", "the", "mouse", "germ-line", "blocks", "spermatogenesis", "."], "h": {"id": "C1413706", "name": "C1413706#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}}
{"token": ["Similar", "results", "were", "obtained", "using", "norepinephrine", "(", "in", "the", "presence", "of", "C0033497#ent", "<e1>", ")", "as", "the", "C0243192#ent", "<e2>", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [16, 17]}}
{"token": ["Animal", "studies", "shown", "that", "C0033497#ent", "<e1>", "is", "a", "potent", "beta-adrenoceptor", "partial", "C0243192#ent", "<e2>", "with", "a", "greater", "affinity", "for", "beta", "1-", "than", "beta", "2-adrenoceptors"], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}}
{"token": ["The", "results", "show", "that", "prenalterol", ",", "xamoterol", "and", "C0033497#ent", "<e1>", "are", "all", "partial", "C0243192#ent", "<e2>", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [13, 14]}}
{"token": ["Based", "on", "studies", "of", "C1823635#ent", "<e1>", "of", "other", "receptors", ",", "the", "C2697642#ent", "<e2>", "is", "predicted", "to", "target", "to", "the", "nucleus", "and", "regulate", "gene", "expression"], "h": {"id": "C1823635", "name": "C1823635#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2697642", "name": "C2697642#ent", "pos": [11, 12]}}
{"token": ["Pretreatment", "of", "mice", "with", "C0022059#ent", "<e1>", "and", "with", "C0030557#ent", "<e2>", "decreased", "11CO2", "excretion", ",", "and", "C0022059#ent", "<e1>", "significantly", "increased", "the", "radioactivity", "retained", "by", "the", "brain", ",", "lungs", "and", "liver", "at", "15", "minutes", "."], "h": {"id": "C0030557", "name": "C0030557#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022059", "name": "C0022059#ent", "pos": [4, 5]}}
{"token": ["Despite", "a", "lack", "of", "functional", "or", "sequence", "similarity", "C2698689#ent", "<e1>", "and", "Tube", ",", "these", "C0086376#ent", "<e2>", "utilize", "a", "common", "surface", "of", "the", "structurally", "similar", "DD", "and", "DED", "to", "recognize", "functionally", "diverse", "targets", "."], "h": {"id": "C2698689", "name": "C2698689#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}}
{"token": ["C0149524#ent", "<e1>", "describes", "a", "combination", "of", "C0005943#ent", "<e2>", "acute", "and", "chronic", "bacterial", "prostatitis", ",", "chronic", "pelvic", "pain", "syndrome", ",", "and", "asymptomatic", "inflammation", "."], "h": {"id": "C0149524", "name": "C0149524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [6, 7]}}
{"token": ["Various", "experimentally", "induced", "and", "C1516876#ent", "<e1>", "hypertensive", "rat", "models", "have", "been", "used", "to", "test", "C3887624#ent", "<e2>", "inhibitors", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [14, 15]}}
{"token": ["Several", "groups", "analyzing", "the", "genetics", "of", "human", "susceptibility", "to", "parasites", "have", "began", "to", "identify", "the", "critical", "steps", "of", "the", "pathogenic", "mechanisms", "in", "a", "few", "C0747256#ent", "<e1>", "as", "malaria", "and", "C0036323#ent", "<e2>", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [24, 25]}, "relation": "nichd_parent_of", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [29, 30]}}
{"token": ["Four", "cases", "of", "C1527336#ent", "<e1>", "reported", ":", "2", "cases", "with", "C0600452#ent", "<e2>", "fibrosing", "alveolitis", "and", "2", "cases", "with", "respiratory", "sarcoidosis"], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0600452", "name": "C0600452#ent", "pos": [10, 11]}}
{"token": ["The", "reductase", "is", "associated", "with", "cytoplasmic", "membrane", "electrons", "can", "reach", "the", "C0014442#ent", "<e1>", "via", "the", "C0041535#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041535", "name": "C0041535#ent", "pos": [15, 16]}}
{"token": ["In", "mammals", "and", "fungi", ",", "MPP", "is", "soluble", "in", "the", "matrix", ",", "whereas", "in", "plants", "the", "C0014442#ent", "<e1>", "is", "part", "of", "the", "C0041535#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0041535", "name": "C0041535#ent", "pos": [22, 23]}}
{"token": ["The", "neutron", "parameters", "were", "compared", "with", "the", "structures", "of", "the", "C0014442#ent", "<e1>", "and", "the", "C0041535#ent", "<e2>", "determined", "by", "electron", "microscopy"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041535", "name": "C0041535#ent", "pos": [14, 15]}}
{"token": ["The", "HSV-1", "polymerase", "more", "sensitive", "than", "the", "EBV", "C0012892#ent", "<e1>", "inhibition", "by", "phosphonoacetate", ",", "C0376236#ent", "<e2>", ",", "aphidicolin", "and", "N-ethylmaleimide", "."], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0376236", "name": "C0376236#ent", "pos": [14, 15]}}
{"token": ["Four", "of", "the", "29", "patients", "(", "13.8", "%", ")", "developed", "C0019158#ent", "<e1>", "during", "chemotherapy", ",", "none", "of", "which", "was", "attributed", "to", "C0019163#ent", "<e2>", "reactivation", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [21, 22]}}
{"token": ["Lamivudine", "was", "introduced", "since", "his", "C0019158#ent", "<e1>", "was", "progressive", "under", "supportive", "treatment", "showed", "an", "elevated", "level", "of", "C0019163#ent", "<e2>", "DNA", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "C2740858#ent", "<e1>", "induced", "a", "dose-dependent", "relaxation", "after", "precontraction", "with", "C0917834#ent", "<e2>", ",", "a", "thromboxane", "A2", "TXA2", ")", "analog", ",", "or", "prostaglandin", "F2", "alpha", "PGF2", "alpha", "in", "the", "veins", "."], "h": {"id": "C2740858", "name": "C2740858#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0917834", "name": "C0917834#ent", "pos": [12, 13]}}
{"token": ["The", "stimulatory", "effect", "of", "AT(1", ")", "was", "completely", "inhibited", "by", "Ro-32", "-", "0432", "(", "a", "C1415545#ent", "<e1>", "and", "PD", "98059", "(", "a", "C0169101#ent", "<e2>", "MEK-1", "]", "inhibitor", ")", "."], "h": {"id": "C1415545", "name": "C1415545#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [22, 23]}}
{"token": ["The", "higher", "oral", "bioavailability", "newer", "C0003451#ent", "<e1>", "part", "of", "the", "extended", "treatment", "period", "of", "patients", "with", "C0276226#ent", "<e2>", "be", "carried", "out", "as", "an", "ambulatory", "oral", "regimen"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0276226", "name": "C0276226#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "since", "the", "introduction", "of", "C0003451#ent", "<e1>", "the", "treatment", "of", "C0276226#ent", "<e2>", "its", "initial", "stages", ",", "the", "prognosis", "of", "the", "disease", "has", "improved", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0276226", "name": "C0276226#ent", "pos": [12, 13]}}
{"token": ["Continuing", "evaluations", "of", "C0003451#ent", "<e1>", "treatment", "of", "C0276226#ent", "<e2>", "HSE", ")", "provided", "an", "opportunity", "to", "collect", "clinical", "data", "113", "patients", "in", "whom", "the", "diagnosis", "was", "proved", "by", "viral", "isolation"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0276226", "name": "C0276226#ent", "pos": [7, 8]}}
{"token": ["Lithium", "led", "to", "a", "statistically", "significant", "enhancement", "of", "the", "C2703161#ent", "<e1>", "blocking", "effects", "of", "suxamethonium", ",", "pancuronium", "and", "C0242531#ent", "<e2>", ",", "but", "not", "of", "the", "other", "myoneural", "blocking", "drugs", "."], "h": {"id": "C2703161", "name": "C2703161#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242531", "name": "C0242531#ent", "pos": [18, 19]}}
{"token": ["Retinoic", "acid", "suppressed", "the", "C0011777#ent", "<e1>", "induced", "increase", "in", "C0538672#ent", "<e2>", "immunoreactivity", "in", "differentiating", "SqCC/Y1", "cells", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0538672", "name": "C0538672#ent", "pos": [9, 10]}}
{"token": ["The", "patient", ",", "a", "22-year-old", "woman", "who", "had", "been", "treated", "for", "systemic", "lupus", "erythematosus", "C0014060#ent", "<e1>", ")", "for", "10", "years", ",", "was", "hospitalized", "for", "C0003862#ent", "<e2>", ",", "melena", ",", "and", "difficulty", "in", "walking", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [24, 25]}}
{"token": ["A", "modified", "angiographic", "Gensini", "Score", "(", "C0017097#ent", "<e1>", ")", "was", "used", "to", "reflect", "the", "extent", "of", "C0010054#ent", "<e2>"], "h": {"id": "C0017097", "name": "C0017097#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [16, 17]}}
{"token": ["Death", "in", "the", "remote", "period", "was", "caused", "by", "disorders", "of", "the", "cardiac", "rhythm", "C0151517#ent", "<e1>", "Morgagni-Adams-Stokes", "syndrome", ",", "\"", "prosthetic", "\"", "endocarditis", ",", "and", "C0155870#ent", "<e2>"], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0155870", "name": "C0155870#ent", "pos": [24, 25]}}
{"token": ["Suppression", "of", "C1705637#ent", "<e1>", "with", "the", "C1705637#ent", "<e1>", "siRNA", "vector", "markedly", "reduced", "the", "infarct", "size", "C0340293#ent", "<e1>", "."], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "C1705637#ent", "<e1>", "in", "the", "heart", "increased", "from", "the", "early", "stage", "C0340293#ent", "<e2>", ",", "and", "this", "increase", "was", "thought", "to", "contribute", "to", "the", "increased", "area", "of", "myocardial", "infarction"], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [13, 14]}}
{"token": ["This", "rare", "malformation", "is", "usually", "associated", "with", "of", "the", "C0010278#ent", "<e1>", "such", "as", "C2931196#ent", "<e2>", "Pfeiffer's", "syndrome", "or", "Goldenhar's", "syndrome"], "h": {"id": "C0010278", "name": "C0010278#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C2931196", "name": "C2931196#ent", "pos": [13, 14]}}
{"token": ["RET", "tyrosine", "kinase", "rearrangements", "which", "represent", "the", "most", "frequent", "genetic", "alteration", "PTC", ",", "lead", "to", "the", "recombination", "of", "C0694890#ent", "<e1>", "with", "heterologous", "genes", "to", "generate", "chimeric", "C1861077#ent", "<e2>"], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [18, 19]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1861077", "name": "C1861077#ent", "pos": [26, 27]}}
{"token": ["To", "examine", "this", "further", ",", "the", "ability", "of", "C1418272#ent", "<e1>", ",", "Cer1", ",", "and", "human", "C1832370#ent", "<e2>", "to", "attenuate", "Bmp4", "signaling", "has", "been", "assessed", "in", "P19", "cells", "pTlx-Lux", ",", "a", "BMP-responsive", "reporter", "."], "h": {"id": "C1418272", "name": "C1418272#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1832370", "name": "C1832370#ent", "pos": [15, 16]}}
{"token": ["Down", "syndrome", "region", "gene", "1-like", "2", "(", "DSCR1L2", ")", "belongs", "to", "the", "human", "DSCR1-like", "C1335597#ent", "<e1>", "which", "also", "includes", "C1414160#ent", "<e2>", "and", "DSCR1L1", "."], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414160", "name": "C1414160#ent", "pos": [19, 20]}}
{"token": ["All", "patients", "with", "this", "inborn", "error", "metabolism", "had", "clinically", "apparent", "C0020757#ent", "<e1>", "and", "a", "family", "history", "this", "C0037274#ent", "<e2>", "with", "X-linked", "inheritance", "."], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [17, 18]}}
{"token": ["6", ")", "In", "rats", "chronically", "fed", "C0059872#ent", "<e1>", ",", "the", "proportion", "of", "C0034343#ent", "<e2>", "quadriceps", "muscle", "the", "active", "form", "31", "%", "compared", "with", "15", "%", "in", "the", "controls", "."], "h": {"id": "C0059872", "name": "C0059872#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034343", "name": "C0034343#ent", "pos": [12, 13]}}
{"token": ["Two", "patients", "with", "C0271097#ent", "<e1>", "ophthalmoplegia", ",", "ataxia", ",", "and", "areflexia", "experienced", "severe", "C3714552#ent", "<e2>", "and", "respiratory", "distress"], "h": {"id": "C0271097", "name": "C0271097#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [13, 14]}}
{"token": ["Phenytoin", "is", "a", "central", "anticholinergic", "agent", "a", "C0304402#ent", "<e1>", "serotonin", ",", "and", "may", "induce", "C0026650#ent", "<e2>", "a", "result", "of", "altering", "these", "neurotransmitters", "in", "the", "brain", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [14, 15]}}
{"token": ["Inflammatory", "bowel", "diseases", "ulcerative", "colitis", "C0156147#ent", "<e1>", "are", "chronic", "long-lasting", "C0033581#ent", "<e2>", "yet", "unknown", "etiology", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [10, 11]}}
{"token": ["All", "nucleotides", "in", "the", "C0079419#ent", "<e1>", "exon", "2", "9", "are", "included", "on", "the", "C0057856#ent", "<e2>", "by", "synthesis", "and", "application", "of", "sequence-specific", "oligonucleotides"], "h": {"id": "C0079419", "name": "C0079419#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0057856", "name": "C0057856#ent", "pos": [13, 14]}}
{"token": ["The", "effects", "of", "dihydropyridine", "Ca2", "C2985407#ent", "<e1>", "DHP", ")", "and", "C0003015#ent", "<e2>", "superoxide", "formation", "nitric", "oxide", "NO", ")", "bioavailability", "were", "compared", "in", "human", "EA.Hy926", "endothelial", "cells", "EC", ")", "."], "h": {"id": "C2985407", "name": "C2985407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [10, 11]}}
{"token": ["In", "conditions", "such", "as", "infection", ",", "cancer", ",", "tissue", "injury", "surgery", ",", "kidney", "disease", "vascular", "disease", "coagulation", ",", "and", "C0011847#ent", "<e1>", ",", "the", "concentrations", "of", "C1332411#ent", "<e2>", "in", "plasma", "and", "urine", "are", "increased", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1332411", "name": "C1332411#ent", "pos": [25, 26]}}
{"token": ["Nucleotide", "sequence", "analysis", "that", "the", "majority", "of", "20", "subtraction-enriched", "cDNA", "fragments", "were", "well-characterized", "C0037207#ent", "<e1>", "and", "tumor-associated", "genes", "like", "c-myc", ",", "alpha-prothymosin", ",", "C3470429#ent", "<e2>", ",", "glutathione-S", "transferase", "G-ST", ")", "and", "alpha", "1-acid", "glycoprotein", "AGP", ")", "."], "h": {"id": "C0037207", "name": "C0037207#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [23, 24]}}
{"token": ["Using", "purified", "recombinant", "proteins", "we", "have", "shown", "that", "C3274761#ent", "<e1>", "binds", "to", "C1413898#ent", "<e2>", "directly", "in", "a", "RanGTP-dependent", "manner", "."], "h": {"id": "C3274761", "name": "C3274761#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413898", "name": "C1413898#ent", "pos": [12, 13]}}
{"token": ["Detergent", ",", "alkaline", "and", "salt", "extractions", "postsynaptic", "densities", "synaptic", "membranes", "that", "C1332712#ent", "<e1>", "and", "pgp117", "are", "C0021699#ent", "<e2>", "are", "tightly", "bound", "components", "of", "postsynaptic", "density", "preparations"], "h": {"id": "C1332712", "name": "C1332712#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [16, 17]}}
{"token": ["The", "sensor", "kinase", "recognizes", "misfolded", "periplasmic", "proteins", "such", "as", "those", "generated", "during", "pilus", "assembly", "and", "transduces", "this", "signal", "to", "the", "response", "regulator", "C1844853#ent", "<e1>", "through", "conserved", "C1335408#ent", "<e2>", "reactions", "."], "h": {"id": "C1844853", "name": "C1844853#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1335408", "name": "C1335408#ent", "pos": [26, 27]}}
{"token": ["This", "C0031727#ent", "<e1>", ",", "which", "we", "provisionally", "denote", "MEK", "for", "C1434639#ent", "<e2>", "phosphorylated", "kinase-inactive", "Erk-1", "protein", "primarily", "on", "a", "tyrosine", "residue", ",", "to", "a", "lesser", "extent", ",", "on", "a", "threonine", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1434639", "name": "C1434639#ent", "pos": [10, 11]}}
{"token": ["In", "the", "alpha-complementation", "of", "beta-galactosidase", "an", "N-terminal", "peptide", "fragment", "alpha-peptide", ")", "of", "the", "C2987364#ent", "<e1>", "enzyme", "interacts", "with", "a", "defective", "beta-galactosidase", "enzyme", "restore", "capacity", "for", "C3814378#ent", "<e2>", "activity", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3814378", "name": "C3814378#ent", "pos": [25, 26]}}
{"token": ["Big", "MAP", "kinase", "1", "C1334481#ent", "<e1>", ")", ",", "also", "known", "as", "C1174318#ent", "<e2>", "ERK5", ")", ",", "is", "a", "recently", "identified", "MAP", "kinase", "family", "member", "was", "reported", "to", "be", "sensitive", "to", "osmotic", "and", "oxidative", "stress"], "h": {"id": "C1334481", "name": "C1334481#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1174318", "name": "C1174318#ent", "pos": [11, 12]}}
{"token": ["Big", "mitogen-activated", "protein", "kinase", "1", "C1334481#ent", "<e1>", ")", ",", "also", "known", "as", "C1174318#ent", "<e2>", "ERK5", ")", ",", "is", "a", "newly", "identified", "member", "of", "the", "mitogen-activated", "protein", "MAP", ")", "kinase", "family"], "h": {"id": "C1334481", "name": "C1334481#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1174318", "name": "C1174318#ent", "pos": [12, 13]}}
{"token": ["The", "biological", "effects", "A-II", "in", "BAC", ",", "C4277588#ent", "<e1>", "cortisol", "production", "were", "inhibited", "in", "a", "dose-dependent", "manner", "by", "C1705666#ent", "<e2>", "753", ",", "but", "not", "by", "AT2", "antagonists", "."], "h": {"id": "C4277588", "name": "C4277588#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705666", "name": "C1705666#ent", "pos": [18, 19]}}
{"token": ["The", "amino-terminal", "half", "C1823489#ent", "<e1>", "with", "a", "RING", "finger", "motif", "fused", "to", "the", "C0072479#ent", "<e2>", "leading", "to", "a", "transforming", "sequence", "Rfp/Ret", "."], "h": {"id": "C1823489", "name": "C1823489#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072479", "name": "C0072479#ent", "pos": [13, 14]}}
{"token": ["The", "output", "comprises", "a", "risk", "of", "C0024894#ent", "<e1>", "a", "relative", "degree", "of", "C0221763#ent", "<e2>"], "h": {"id": "C0024894", "name": "C0024894#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221763", "name": "C0221763#ent", "pos": [12, 13]}}
{"token": ["The", "clavicular-Fpz", "response", "was", "bilobed", "in", "77", "%", "of", "the", "recordings", ",", "the", "initial", "negativity", "being", "designated", "C1427215#ent", "<e1>", "and", "the", "following", "negativity", ",", "C3147238#ent", "<e2>", "."], "h": {"id": "C1427215", "name": "C1427215#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3147238", "name": "C3147238#ent", "pos": [24, 25]}}
{"token": ["The", "mitochondrial", "C1704945#ent", "<e1>", "activity", ",", "which", "is", "primarily", "C1826449#ent", "<e2>", "activity", ",", "was", "not", "significantly", "altered", "in", "the", "FALS-1", ",", "FALS-O", ",", "or", "SALS", "patients", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826449", "name": "C1826449#ent", "pos": [9, 10]}}
{"token": ["LBHIs", "of", "both", "familial", "and", "sporadic", "C1704945#ent", "<e1>", "were", "negatively", "stained", "for", "C1826449#ent", "<e2>", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1826449", "name": "C1826449#ent", "pos": [12, 13]}}
{"token": ["Unfortunately", ",", "nothing", "is", "known", "about", "the", "enzymatic", "activity", "catalyzed", "by", "this", "C2698695#ent", "<e1>", ",", "but", "a", "C0085249#ent", "<e2>", "be", "postulated", "to", "allow", "complete", "peptidoglycan", "synthesis", "."], "h": {"id": "C2698695", "name": "C2698695#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [17, 18]}}
{"token": ["Especially", ",", "it", "was", "completely", "C1512488#ent", "<e1>", "with", "that", "of", "human", "liver", "C1824884#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1824884", "name": "C1824884#ent", "pos": [12, 13]}}
{"token": ["TNF-alpha", "is", "a", "proinflammatory", "cytokine", "involved", "in", "many", "inflammatory", "conditions", "as", "C0156147#ent", "<e1>", "rheumatoid", "arthritis", "cachexia", ",", "AIDS", ",", "and", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [22, 23]}}
{"token": ["Mice", "heterozygous", "for", "the", "disrupted", "C1450093#ent", "<e1>", "allele", "were", "used", "to", "examine", "the", "effect", "of", "C1413859#ent", "<e2>", "on", "DBP", "transplacental", "carcinogenesis"], "h": {"id": "C1450093", "name": "C1450093#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413859", "name": "C1413859#ent", "pos": [15, 16]}}
{"token": ["Plasma", "cholesterol", "concentrations", "and", "rates", "of", "secretion", "of", "VLDL", "cholesterol", "triglycerides", "were", "27", ",", "47", "and", "34", "%", "higher", ",", "respectively", ",", "in", "animals", "fed", "casein", "plus", "C1161331#ent", "<e1>", "compared", "with", "C0950114#ent", "<e2>"], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0950114", "name": "C0950114#ent", "pos": [31, 32]}}
{"token": ["These", "results", "suggest", "that", "the", "prognosis", "of", "urinary", "\u03b2", "2-MG-positive", "subjects", "with", "Cd-induced", "renal", "C0015624#ent", "<e1>", "unfavorable", ",", "with", "higher", "mortality", "rates", "to", "renal", "diseases", "C0007785#ent", "<e2>", "heart", "failure", "to", "this", "."], "h": {"id": "C0015624", "name": "C0015624#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [25, 26]}}
{"token": ["The", "cyclic", "AMP", "C0031640#ent", "<e1>", "activity", "in", "the", "cytosolic", "fraction", "enhanced", "in", "the", "presence", "of", "C0769224#ent", "<e2>", "."], "h": {"id": "C0031640", "name": "C0031640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0769224", "name": "C0769224#ent", "pos": [15, 16]}}
{"token": ["The", "hyperprolactinemia", ",", "C0022735#ent", "<e1>", "hyperaldosteronism", "and", "hypokalemia", "subsided", "with", "the", "administration", "of", "C0006230#ent", "<e2>", "5", "mg/day", "."], "h": {"id": "C0022735", "name": "C0022735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [13, 14]}}
{"token": ["The", "levels", "of", "C0022478#ent", "<e1>", "and", "collagenase", "in", "synovial", "fluid", "C0038013#ent", "<e2>", "RA", ")", "patients", "were", "examined", "and", "the", "role", "of", "C0022478#ent", "<e1>", "in", "procollagenase", "activation", "discussed", "."], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [10, 11]}}
{"token": ["To", "provide", "evidence", "for", "three-level", "prevention", "of", "C0008350#ent", "<e1>", "by", "means", "of", "observing", "the", "effects", "of", "some", "C1880071#ent", "<e2>", "on", "bile", "compositions", "from", "patients", "with", "pigment", "gallstone"], "h": {"id": "C0008350", "name": "C0008350#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1880071", "name": "C1880071#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "to", "assess", "the", "efficacy", "of", "this", "type", "of", "combination", "therapy", "C0011860#ent", "<e1>", "we", "conducted", "a", "double-blind", "clinical", "trial", "with", "C0040372#ent", "<e2>", "and", "insulin", "in", "15", "subjects", "with", "C0011860#ent", "<e1>"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0040372", "name": "C0040372#ent", "pos": [21, 22]}}
{"token": ["The", "chronic", "and", "acute", "neurological", "and", "psychiatric", "symptoms", "homocystinuria", "patients", "offer", "a", "clue", "to", "studies", "of", "the", "neurotoxic", "but", "also", "C0040615#ent", "<e1>", "potency", "of", "C0242910#ent", "<e2>", "the", "SCAAs", "in", "humans", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0242910", "name": "C0242910#ent", "pos": [24, 25]}}
{"token": ["Immune", "serum", "rabbit", "has", "been", "obtained", "against", "Campylobacter", "jejuni", "ATCC", "no", "29428", "from", "the", "same", "strain", "an", "antigen", "of", "the", "outer", "C0017343#ent", "<e1>", "was", "prepared", "by", "C0012695#ent", "<e2>", "extraction", "."], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [26, 27]}}
{"token": ["Severe", "C0031090#ent", "<e1>", "arbitrarily", "defined", "as", "mean", "CAL", "or", "C0080279#ent", "<e2>", ">", "or", "=", "3", "mm", "."], "h": {"id": "C0031090", "name": "C0031090#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [9, 10]}}
{"token": ["C0057459#ent", "<e1>", "ubiquitously", "expressed", "in", "human", "tissues", ",", "and", "the", "DNase", "II", "gene", "C1414111#ent", "<e2>", ")", "was", "assigned", "to", "chromosome", "19"], "h": {"id": "C0057459", "name": "C0057459#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414111", "name": "C1414111#ent", "pos": [13, 14]}}
{"token": ["Even", "excessive", "contamination", "of", "lymphocyte", "suspensions", "with", "platelets", "did", "not", "appreciably", "alter", "the", "C0020289#ent", "<e1>", "activity", "of", "lymphocyte", "homogenates", "or", "the", "distribution", "of", "C3540790#ent", "<e2>", "in", "subcellular", "fractions"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [23, 24]}}
{"token": ["To", "elucidate", "the", "mechanism", "of", "acquired", "resistance", "C0014582#ent", "<e1>", ",", "we", "searched", "for", "genes", "that", ",", "when", "C3889446#ent", "<e2>", ",", "render", "Saccharomyces", "cerevisiae", "resistant", "to", "C0014582#ent", "<e1>", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [17, 18]}}
{"token": ["KY-VCR", "showed", "a", "decreased", "uptake", "and", ",", "an", "increased", "efflux", "of", "vincristine", ",", "and", "cross-resistance", "to", "C0014582#ent", "<e1>", "and", "Actinomycin", "D.", "The", "M(r", ")", "200,000", "membrane", "glycoprotein", "C3889446#ent", "<e2>", "in", "KY-VCR", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [27, 28]}}
{"token": ["Of", "the", "type", "I", "receptors", "C1423097#ent", "<e1>", "was", "found", "to", "interact", "only", "with", "inactivated", "C3540638#ent", "<e2>", "."], "h": {"id": "C1423097", "name": "C1423097#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540638", "name": "C3540638#ent", "pos": [14, 15]}}
{"token": ["A", "series", "of", "C0002556#ent", "<e1>", "has", "been", "C2350558#ent", "<e2>", "onto", "glass", "microscope", "slides", ",", "and", "binding", "to", "proteins", "and", "RNAs", "has", "been", "detected", "by", "fluorescence", "."], "h": {"id": "C0002556", "name": "C0002556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [7, 8]}}
{"token": ["Monocarboxylate", "transport", "C1420108#ent", "<e1>", "could", "be", "inhibited", "by", "alpha-cyano-4-hydroxycinnamate", ",", "C0872271#ent", "<e2>", "flavonoids", "."], "h": {"id": "C1420108", "name": "C1420108#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0872271", "name": "C0872271#ent", "pos": [10, 11]}}
{"token": ["C0003864#ent", "<e1>", "patients", ",", "other", "than", "those", "with", "C0018099#ent", "<e2>", ",", "should", "increase", "their", "intake", "of", "oily", "fish", "additionally", "supplement", "with", "fish", "oil", "up", "to", "3", "months", "to", "see", "whether", "they", "experience", "benefit", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [8, 9]}}
{"token": ["We", "investigated", "the", "gamma-carboxyglutamic", "acid", "Gla", ")", "independent", "effect", "of", "C2936886#ent", "<e1>", "on", "the", "activity", "of", "C0015520#ent", "<e2>"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0015520", "name": "C0015520#ent", "pos": [16, 17]}}
{"token": ["As", "with", "the", "C2987634#ent", "<e1>", ",", "the", "rise", "in", "serum", "corticosterone", "with", "C1097302#ent", "<e2>", "(", "an", "mGlu1/5", "antagonist", ",", "EC50", "=", "20", "nmol", ",", "i.c.v", ".", ")"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1097302", "name": "C1097302#ent", "pos": [12, 13]}}
{"token": ["Lack", "of", "Btk", "in", "XLA", "patients", "downstream", "of", "TLR8", "and", "C1423633#ent", "<e1>", "might", "explain", "the", "susceptibility", "of", "XLA", "patients", "to", "C0162628#ent", "<e2>"], "h": {"id": "C1423633", "name": "C1423633#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [20, 21]}}
{"token": ["These", "results", "indicate", "that", "TLR3", ",", "TLR7", "and", "C1423633#ent", "<e1>", "may", "play", "an", "important", "role", "in", "detecting", "and", "combating", "C0162628#ent", "<e2>"], "h": {"id": "C1423633", "name": "C1423633#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [19, 20]}}
{"token": ["Aberrant", "smooth", "muscle", "dystonia", "hemolytic", "episodes", "C1418558#ent", "<e1>", "PNH", ")", "is", "implicated", "in", "the", "symptoms", "of", "abdominal", "pain", "C0011168#ent", "<e2>", "and", "erectile", "dysfunction"], "h": {"id": "C1418558", "name": "C1418558#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [18, 19]}}
{"token": ["A", "decrease", "in", "distribution", "volumes", "was", "seen", "in", "control", "goats", "with", "C0010980#ent", "<e1>", ",", "sulphisomidine", "and", "C0700599#ent", "<e2>", ",", "but", "was", "only", "significant", "for", "C0700599#ent", "<e2>", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0700599", "name": "C0700599#ent", "pos": [16, 17]}}
{"token": ["The", "C0136073#ent", "<e1>", "extracted", "using", "C0047101#ent", "<e2>", "as", "detergent", ",", "and", "was", "purified", "to", "a", "22-kDa", "protein", "(", "SDS/PAGE", ")", "."], "h": {"id": "C0136073", "name": "C0136073#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0047101", "name": "C0047101#ent", "pos": [5, 6]}}
{"token": ["C0027396#ent", "<e1>", "significantly", "reduced", "the", "symptoms", "of", "C0030193#ent", "<e2>", "temporomandibular", "joint", "disc-displacement", "TMJ", "DD", ")", "with", "reduction", "as", "determined", "by", "most", "efficacy", "measures", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [7, 8]}}
{"token": ["C0432317#ent", "<e1>", "EBS", ")", "is", "a", "group", "of", "predominantly", "C2936739#ent", "<e2>", "hereditary", "disorders", "the", "skin", ",", "which", "manifest", "as", "superficial", "skin", "blisters", "minimal", "mechanical", "trauma", "."], "h": {"id": "C0432317", "name": "C0432317#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [9, 10]}}
{"token": ["In", "undiagnosed", "C0037928#ent", "<e1>", ",", "metrizamide", "myelography", "the", "potential", "to", "detect", "unsuspected", "C0039144#ent", "<e2>", "even", "when", "the", "cord", "is", "normal-sized", "or", "small", "."], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0039144", "name": "C0039144#ent", "pos": [12, 13]}}
{"token": ["Despite", "modest", "or", "minimal", "signs", "of", "C0037928#ent", "<e1>", ",", "each", "patient", "had", "C0039144#ent", "<e2>", "detected", "with", "MRI", "."], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0039144", "name": "C0039144#ent", "pos": [12, 13]}}
{"token": ["Micronomicin", "(", "MCR", ",", "C0066520#ent", "<e1>", ")", ",", "a", "new", "derivative", "of", "C3536835#ent", "<e2>", ",", "was", "used", "in", "9", "patients", "with", "postoperative", "infection", "caused", "by", "Gram-negative", "bacilli"], "h": {"id": "C0066520", "name": "C0066520#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536835", "name": "C3536835#ent", "pos": [12, 13]}}
{"token": ["C1442484#ent", "<e1>", "an", "essential", "C2717971#ent", "<e2>", "the", "complement", "cascade"], "h": {"id": "C1442484", "name": "C1442484#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [4, 5]}}
{"token": ["C2698198#ent", "<e1>", "alone", "did", "not", "affect", "C4255305#ent", "<e2>", "responses", "to", "noradrenaline", ",", "potassium", ",", "or", "to", "sympathetic", "nerve", "stimulation", "."], "h": {"id": "C2698198", "name": "C2698198#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4255305", "name": "C4255305#ent", "pos": [6, 7]}}
{"token": ["A", "case", "of", "a", "12-month-old", "child", "with", "C0401151#ent", "<e1>", "weight", "loss", "abdominal", "distension", "hypokalaemia", "and", "hypochlorhydria", ",", "which", "were", "associated", "with", "C1366646#ent", "<e2>", "ganglioneuroma", ",", "is", "reported", "."], "h": {"id": "C0401151", "name": "C0401151#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366646", "name": "C1366646#ent", "pos": [21, 22]}}
{"token": ["C0072522#ent", "<e1>", "CD28-IgG", "and", "CD80-Fab", "were", "cross-linked", "in", "vitro", "C0046905#ent", "<e2>", ",", "characterized", "by", "nonreducing", "SDS-PAGE", ",", "digested", "in", "situ", "trypsin", "and", "analyzed", "by", "MALDI-MS", "peptide", "mapping", "(", "+", "/-", "thiol", "reagent", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0046905", "name": "C0046905#ent", "pos": [9, 10]}}
{"token": ["This", "study", "aims", "to", "compare", "economic", "and", "patient", "impacts", "of", "the", "treatment", "of", "C0001206#ent", "<e1>", "with", "two", "different", "somatostatin", "analogues", "octreotide", "LAR", "C0209211#ent", "<e2>", "SR", ")", "in", "Brazil", "."], "h": {"id": "C0001206", "name": "C0001206#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0209211", "name": "C0209211#ent", "pos": [22, 23]}}
{"token": ["Pretreatment", "with", "C0021974#ent", "<e1>", "resulted", "in", "a", "33", "%", "decrease", "in", "maximal", "C3273356#ent", "<e2>", "values", ",", "indicating", "the", "presence", "and", "functional", "importance", "of", "granule", "thiols"], "h": {"id": "C0021974", "name": "C0021974#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273356", "name": "C3273356#ent", "pos": [12, 13]}}
{"token": ["To", "further", "examine", "autophagy", ",", "hepatocytes", "were", "infected", "with", "an", "adenovirus", "expressing", "C1311384#ent", "<e1>", "GFP-LC3", ")", "and", "subjected", "to", "A/R.", "C1413109#ent", "<e2>", "activity", "was", "fluorometrically", "determined", "with", "succinyl-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarin", "."], "h": {"id": "C1311384", "name": "C1311384#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413109", "name": "C1413109#ent", "pos": [20, 21]}}
{"token": ["To", "measure", "synovial", "fluid", "C1442521#ent", "<e1>", ")", "levels", "of", "C3536785#ent", "<e2>", "IL-1ra", ")", "and", "to", "determine", "the", "capacity", "of", "C1442521#ent", "<e1>", "neutrophils", "(", "PMN", ")", "to", "synthesize", "and", "release", "IL-1ra", "."], "h": {"id": "C3536785", "name": "C3536785#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [4, 5]}}
{"token": ["We", "explored", "the", "C0039051#ent", "<e1>", "property", "of", "C0113293#ent", "<e2>", ",", "especially", "its", "role", "in", "intraocular", "pressure", "IOP", ")", "reduction", ",", "haemodynamic", "stability", "and", "attenuation", "of", "extubation", "response", "."], "h": {"id": "C0039051", "name": "C0039051#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0113293", "name": "C0113293#ent", "pos": [7, 8]}}
{"token": ["Antimetabolites", ",", "especially", "antifolates", ",", "play", "an", "important", "role", "in", "the", "treatment", "of", "a", "variety", "of", "both", "malignant", ",", "and", "non-malignant", "diseases", "such", "as", "C0038013#ent", "<e1>", "and", "bacterial", "and", "C0030499#ent", "<e2>"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [29, 30]}}
{"token": ["The", "amino", "acid", "changes", "do", "not", "affect", "the", "level", "or", "cellular", "localization", "the", "C1564140#ent", "<e1>", "since", "equal", "amounts", "of", "wild", "type", "mutant", "C1424934#ent", "<e2>", "were", "detected", "in", "the", "mitochondrial", "compartment"], "h": {"id": "C1564140", "name": "C1564140#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1424934", "name": "C1424934#ent", "pos": [22, 23]}}
{"token": ["Inhibition", "of", "thrombin", "receptor", "protease-activated", "receptor", "1", "C1838543#ent", "<e1>", ")", "has", "been", "shown", "to", "reduce", "C0239946#ent", "<e2>", "animals", "."], "h": {"id": "C1838543", "name": "C1838543#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0239946", "name": "C0239946#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "long-acting", "angiotensin-converting", "enzyme", "inhibitor", "C0770917#ent", "<e1>", "exercise", "tolerance", "signs", "and", "symptoms", "of", "C0018802#ent", "<e2>", "CHF", ")", "were", "evaluated", "in", "a", "double-blind", ",", "multicenter", ",", "placebo-controlled", "clinical", "trial"], "h": {"id": "C0770917", "name": "C0770917#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["We", "previously", "demonstrated", "that", "oxidized", "frying", "oil", "(", "OFO", ")", "activates", "peroxisome", "proliferator-activated", "receptor", "alpha", "C2984537#ent", "<e1>", ")", "and", "up-regulates", "hepatic", "acyl-CoA", "oxidase", "ACO", ")", "and", "C0010762#ent", "<e2>", "CYP4A1", ")", "genes", "in", "male", "rats", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [26, 27]}}
{"token": ["These", "C0012315#ent", "<e1>", "structurally", "similar", "to", "C0028066#ent", "<e2>", ",", "the", "most", "widely", "studied", "dihydropyridine", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [6, 7]}}
{"token": ["The", "inv(16)(p13q22", ")", "or", ",", "less", "commonly", ",", "the", "t(16;16)(p13;q22", ")", "causes", "fusion", "of", "the", "CBFbeta", "gene", "16q22", "and", "the", "C1334538#ent", "<e1>", "16p13", ",", "creating", "the", "novel", "C0381246#ent", "<e2>"], "h": {"id": "C1334538", "name": "C1334538#ent", "pos": [20, 21]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0381246", "name": "C0381246#ent", "pos": [27, 28]}}
{"token": ["Epidemiological", "investigations", "have", "indicated", "that", "the", "moderate", "consumption", "of", "C1823832#ent", "<e1>", "products", "such", "as", "red", "wine", "C0453269#ent", "<e2>", "associated", "with", "lower", "risk", "of", "cardiovascular", "disease", "improvement", "of", "visual", "functions"], "h": {"id": "C1823832", "name": "C1823832#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0453269", "name": "C0453269#ent", "pos": [16, 17]}}
{"token": ["An", "open-label", "study", "a", "double", "blind", "study", "and", "a", "study", "comparing", "bromocriptine", "to", "C0596007#ent", "<e1>", "provided", "evidence", "that", "C0006230#ent", "<e2>", "reduced", "flares", "and", "suppressed", "disease", "activity", "SLE", "."], "h": {"id": "C0596007", "name": "C0596007#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [18, 19]}}
{"token": ["C0699739#ent", "<e1>", "a", "prominent", "component", "of", "C0011882#ent", "<e2>"], "h": {"id": "C0699739", "name": "C0699739#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011882", "name": "C0011882#ent", "pos": [6, 7]}}
{"token": ["Decrease", "of", "the", "therapy", "C0003195#ent", "<e1>", "p", "<", "0.05", ")", "in", "patients", ",", "who", "took", "C0020261#ent", "<e2>", ",", "was", "noticed", "too", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [15, 16]}}
{"token": ["Derivatives", "of", "benzamidine", "inhibit", "competitively", "the", "activity", "of", "the", "C2717971#ent", "<e1>", "plasmin", ",", "thrombin", ",", "and", "of", "the", "C0015520#ent", "<e2>"], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015520", "name": "C0015520#ent", "pos": [18, 19]}}
{"token": ["Phages", "rescued", "from", "this", "cDNA", "expression", "library", "were", "subjected", "to", "biopanning", "against", "two", "C2717971#ent", "<e1>", "trypsin", "and", "the", "C0015520#ent", "<e2>"], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0015520", "name": "C0015520#ent", "pos": [18, 19]}}
{"token": ["The", "endogenous", "C0031727#ent", "<e1>", "is", "identified", "as", "casein", "kinase", "II", "C3490418#ent", "<e2>", "based", "on", "its", "ability", "to", "use", "GTP", "as", "effectively", "as", "ATP", ",", "and", "its", "inhibition", "by", "La3", "+", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3490418", "name": "C3490418#ent", "pos": [10, 11]}}
{"token": ["These", "are", "revealed", "to", "be", "related", "spliceosome", "proteins", "HYPA/FBP-11", "and", "HYPC", ")", "and", "a", "transcription", "factor", "C1822686#ent", "<e1>", ")", "that", "implicate", "C1415504#ent", "<e2>", "in", "mRNA", "biogenesis", "."], "h": {"id": "C1822686", "name": "C1822686#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415504", "name": "C1415504#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "the", "anticholinergic", "activity", "C0878504#ent", "<e1>", "stronger", "than", "that", "of", "C1161352#ent", "<e2>", "when", "parenterally", "administered", ",", "and", "it", "can", "not", "distinguish", "between", "the", "subtypes", "of", "muscarinic", "receptors"], "h": {"id": "C0878504", "name": "C0878504#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [13, 14]}}
{"token": ["Anticholinergic", "properties", "oxitropium", "bromide", "C0878504#ent", "<e1>", "were", "compared", "with", "those", "of", "C1161352#ent", "<e2>", "and", "ipratropium", "bromide", "Sch", "1000", ")", "."], "h": {"id": "C0878504", "name": "C0878504#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [11, 12]}}
{"token": ["One", "proband", "with", "C0948480#ent", "<e1>", "a", "mother", "and", "brother", "affected", ",", "but", "C0039082#ent", "<e2>", "recognised", "in", "them", "."], "h": {"id": "C0948480", "name": "C0948480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "3", "cases", "of", "transient", "left", "ventricular", "apical", "ballooning", "C0948480#ent", "<e1>", "and", "discuss", "the", "etiology", "of", "this", "C0039082#ent", "<e2>", ",", "in", "particular", "the", "possible", "role", "of", "a", "transient", "intraventricular", "gradient", "."], "h": {"id": "C0948480", "name": "C0948480#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}}
{"token": ["The", "other", "10", "subjects", ",", "classified", "as", "C0004096#ent", "<e1>", "demonstrated", "highly", "elevated", "RL", "and", "an", "C1823249#ent", "<e2>", "that", "became", "highly", "elevated", "at", "frequencies", "above", "2", "Hz", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1823249", "name": "C1823249#ent", "pos": [15, 16]}}
{"token": ["The", "roles", "of", "phospholipase", "C", "tyrosine", "kinases", "and", "src", "tyrosine", "kinases", "examined", "using", "specific", "inhibitors", ",", "i.e.", ",", "C1620102#ent", "<e1>", ",", "genistein", ",", "and", "C1417819#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1620102", "name": "C1620102#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417819", "name": "C1417819#ent", "pos": [24, 25]}}
{"token": ["Autopsy-negative", "sudden", "unexplained", "death", ",", "including", "C0038644#ent", "<e1>", "can", "be", "caused", "by", "C1720983#ent", "<e2>", "as", "Brugada", "syndrome", "BrS", ")", "."], "h": {"id": "C0038644", "name": "C0038644#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1720983", "name": "C1720983#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "during", "the", "course", "of", "this", "study", ",", "we", "found", "that", "the", "biological", "effect", "C1825781#ent", "<e1>", "varied", "dramatically", "with", "the", "level", "of", "C1334325#ent", "<e2>", "expressed", "."], "h": {"id": "C1825781", "name": "C1825781#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1334325", "name": "C1334325#ent", "pos": [23, 24]}}
{"token": ["These", "results", "thus", "define", "three", "new", "groups", ",", "FA-F", ",", "FA-G", ",", "and", "C2828026#ent", "<e1>", ",", "providing", "evidence", "for", "a", "minimum", "of", "eight", "distinct", "C0015625#ent", "<e2>", "genes", "."], "h": {"id": "C2828026", "name": "C2828026#ent", "pos": [13, 14]}, "relation": "gene_associated_with_disease", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [24, 25]}}
{"token": ["The", "results", "indicate", "that", "scopolamine", "and", "C0012381#ent", "<e1>", "exert", "their", "effect", "in", "C0026603#ent", "<e2>", "reducing", "the", "vestibular", "and", "visual", "influx", "and", "by", "partly", "inhibiting", "the", "integrative", "functioning", "the", "vestibular", "nuclei"], "h": {"id": "C0012381", "name": "C0012381#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0026603", "name": "C0026603#ent", "pos": [12, 13]}}
{"token": ["Administration", "of", "OE2", "to", "ovx", "rats", "decreased", "uterine", "C0123707#ent", "<e1>", "mRNA", "and", "increased", "C1334095#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334095", "name": "C1334095#ent", "pos": [13, 14]}}
{"token": ["C0123707#ent", "<e1>", "expression", "was", "higher", "in", "ER", "negative", "tumors", "while", "that", "of", "C1334095#ent", "<e2>", "and", "-5", "was", "higher", "in", "ER", "positive", "specimens", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334095", "name": "C1334095#ent", "pos": [12, 13]}}
{"token": ["Fusions", "of", "the", "lacZ", "gene", "both", "C1707164#ent", "<e1>", "and", "impX", "reveal", "that", "the", "transcription", "of", "both", "C1417679#ent", "<e2>", "is", "induced", "in", "the", "presence", "of", "adenosine", "."], "h": {"id": "C1707164", "name": "C1707164#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["The", "inhibition", "of", "MAO-B", "by", "C1419059#ent", "<e1>", "may", "have", "been", "the", "means", "by", "which", "progression", "of", "C0242422#ent", "<e2>", "was", "attenuated", ",", "although", "other", "mechanisms", "are", "also", "tenable", "."], "h": {"id": "C1419059", "name": "C1419059#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [16, 17]}}
{"token": ["In", "a", "different", "C0026848#ent", "<e1>", ",", "myotonic", "dystrophy", "DM", ")", ",", "a", "juvenile", "C0597298#ent", "<e2>", "of", "the", "skeletal", "RyR", "is", "preferentially", "expressed", "in", "adults", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [13, 14]}}
{"token": ["Studies", "using", "phentolamine", ",", "a", "specific", "C3536752#ent", "<e1>", "apyrase", ",", "or", "creatine", "phosphate/creatine", "kinase", "that", "the", "exposure", "of", "C1416498#ent", "<e2>", "epinephrine", "was", "specific", "for", "platelet", "alpha-adrenergic", "receptor", "stimulation", "and", "was", "not", "the", "result", "of", "released", "ADP", "."], "h": {"id": "C3536752", "name": "C3536752#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416498", "name": "C1416498#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "the", "effects", "of", "IL-1", "on", "the", "production", "of", "tissue-type", "plasminogen", "activator", "t-PA", ")", ",", "C1522670#ent", "<e1>", "(", "u-PA", ")", "and", "PAI-1", "by", "C0268731#ent", "<e2>"], "h": {"id": "C1522670", "name": "C1522670#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [24, 25]}}
{"token": ["C0077027#ent", "<e1>", "can", "quench", "fluorescence", "is", "emitted", "by", "fluorescein", "retained", "in", "C0037299#ent", "<e2>", "causing", "a", "false-negative", "reaction"], "h": {"id": "C0077027", "name": "C0077027#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037299", "name": "C0037299#ent", "pos": [11, 12]}}
{"token": ["Interestingly", ",", "all", "GAGE-like", "genes", "contain", "a", "large", "C0079941#ent", "<e1>", "coding", "for", "putative", "proteins", "homologues", "to", "the", "C3539822#ent", "<e2>", "primary", "protein"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539822", "name": "C3539822#ent", "pos": [17, 18]}}
{"token": ["Exponentially", "proliferating", "cultured", "cell", "populations", "exposed", "to", "selected", "homoharringtonine", "(", "C0039445#ent", "<e1>", ")", "concentrations", "for", "24", "h", "and", "the", "C1332416#ent", "<e2>", "cell", "fractions", "determined", "by", "colony", "formation", "in", "semisolid", "medium"], "h": {"id": "C0039445", "name": "C0039445#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [19, 20]}}
{"token": ["This", "could", "explain", ",", "at", "least", "in", "part", ",", "the", "C0003292#ent", "<e1>", "fermented", "products", "those", "on", "C0277528#ent", "<e2>", "against", "colonization", "by", "Helicobacter", "pylori"], "h": {"id": "C0003292", "name": "C0003292#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0277528", "name": "C0277528#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "the", "usefulness", "of", "C0026056#ent", "<e1>", "as", "a", "therapeutic", "agent", "C0038220#ent", "<e2>", "conventional", "treatment"], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [11, 12]}}
{"token": ["The", "adenosine", "agonist", "NECA", "(", "100", "micromol/L", ")", "increased", "interleukin-8", "(", "C1705592#ent", "<e1>", ")", ",", "vascular", "endothelial", "growth", "factor", "VEGF", ")", ",", "and", "C0540511#ent", "<e2>", "mRNA", "expression", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0540511", "name": "C0540511#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "in", "cells", "microinjected", "with", "antisense", "oligonucleotides", "against", "the", "C1537503#ent", "<e1>", "mRNA", "the", "sterol-stimulated", "C1823584#ent", "<e2>", "influx", "was", "reduced", "up", "to", "60", "%", "respect", "to", "uninjected", "cells", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1823584", "name": "C1823584#ent", "pos": [15, 16]}}
{"token": ["Absence", "of", "the", "transcription", "factor", "Scurfin", "(", "also", "known", "as", "C3539868#ent", "<e1>", "encoded", "by", "C1416467#ent", "<e2>", ")", "causes", "a", "rapidly", "fatal", "lymphoproliferative", "disease", "similar", "to", "that", "seen", "in", "mice", "lacking", "cytolytic", "T", "lymphocyte-associated", "antigen", "4", "CTLA-4", ")", "."], "h": {"id": "C3539868", "name": "C3539868#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416467", "name": "C1416467#ent", "pos": [14, 15]}}
{"token": ["We", "found", "that", "a", "SNP", "(", "rs10521496", ")", "covered", "by", "DIAPH2", ",", "known", "to", "cause", "C0025322#ent", "<e1>", "POF", ")", "in", "females", ",", "is", "associated", "with", "C0242383#ent", "<e2>"], "h": {"id": "C0025322", "name": "C0025322#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [25, 26]}}
{"token": ["While", "oral", "administration", "C0032912#ent", "<e1>", "effectively", "inhibited", "the", "formation", "of", "all", "eicosanoids", "in", "the", "C0001614#ent", "<e2>", ",", "the", "addition", "of", "C0032912#ent", "<e1>", "in", "vitro", "physiological", "concentrations", "showed", "no", "such", "effect", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [3, 4]}}
{"token": ["In", "response", "to", "DNA", "damage", "replication", "fork", "stress", "the", "C0015625#ent", "<e1>", "activated", ",", "leading", "to", "monoubiquitination", "of", "FANCD2", "and", "C1825278#ent", "<e2>", "and", "their", "colocalization", "in", "foci", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [9, 10]}, "relation": "disease_has_associated_gene", "t": {"id": "C1825278", "name": "C1825278#ent", "pos": [19, 20]}}
{"token": ["Concentrations", "of", "polyamines", ",", "C3539946#ent", "<e1>", "glycogen", ",", "nucleic", "acids", "protein", ",", "and", "activities", "of", "ornithine", "decarboxylase", "C1412379#ent", "<e2>", "were", "measured", "in", "livers", "from", "control", ",", "streptozotocin-diabetic", "and", "insulin-treated", "diabetic", "rats", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412379", "name": "C1412379#ent", "pos": [17, 18]}}
{"token": ["The", "C.", "elegans", "C1412379#ent", "<e1>", "mRNA", "possesses", "an", "open", "reading", "frame", "ORF", ")", "which", "encodes", "a", "polypeptide", "of", "368", "C3539946#ent", "<e2>", "corresponding", "to", "a", "C1412379#ent", "<e1>", "proenzyme", "with", "a", "calculated", "molecular", "mass", "42141", "Da", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412379", "name": "C1412379#ent", "pos": [3, 4]}}
{"token": ["The", "use", "of", "C1412325#ent", "<e1>", "is", "illustrated", "in", "a", "series", "of", "C1851585#ent", "<e2>", "vs.", "IgC", "curves", ",", "calculated", "for", "selected", "examples", "of", "negatively", "charged", "lipid", "membranes"], "h": {"id": "C1412325", "name": "C1412325#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1851585", "name": "C1851585#ent", "pos": [11, 12]}}
{"token": ["Induction", "by", "C0000979#ent", "<e1>", "is", "abolished", "in", "mutants", "unable", "to", "metabolize", "C0000979#ent", "<e1>", "via", "the", "TCA", "cycle", "and", "induction", "by", "amino", "acids", "metabolized", "via", "C1291208#ent", "<e1>", "is", "lost", "in", "mutants", "unable", "to", "form", "C1291208#ent", "<e1>", "."], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1291208", "name": "C1291208#ent", "pos": [24, 25]}}
{"token": ["Because", "allelic", "variants", "of", "C3714750#ent", "<e1>", "are", "associated", "with", "polymorphic", "expression", "of", "microsomal", "C3714750#ent", "<e1>", "in", "human", "liver", "and", "kidneys", ",", "we", "hypothesized", "that", "C0020823#ent", "<e1>", "N-dechloroethylation", "depends", "on", "C3714750#ent", "<e1>", "genotype", "."], "h": {"id": "C0020823", "name": "C0020823#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C3714750", "name": "C3714750#ent", "pos": [4, 5]}}
{"token": ["Although", "single", "disruptants", "of", "ykl046c", "and", "dfg5", "were", "viable", ",", "ykl046cDelta", "was", "hypersensitive", "to", "a", "cell", "wall-digesting", "enzyme", "(", "C0014106#ent", "<e1>", ")", ",", "suggesting", "that", "this", "C0017337#ent", "<e2>", "is", "involved", "in", "cell", "wall", "biosynthesis"], "h": {"id": "C0014106", "name": "C0014106#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [26, 27]}}
{"token": ["The", "activity", "of", "the", "C0242947#ent", "<e1>", "acetylcholine", ",", "ACh", ";", "acetylcholinesterase", ",", "AChE", ";", "C4082365#ent", "<e2>", "ChAT", ";", "muscarinic", "acetylcholine", "receptors", "was", "studied", "in", "the", "carp", "brain"], "h": {"id": "C0242947", "name": "C0242947#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4082365", "name": "C4082365#ent", "pos": [14, 15]}}
{"token": ["The", "alterations", "of", "C1705590#ent", "<e1>", "as", "activation", "of", "C0029016#ent", "<e2>", ",", "gene", "amplification", "and", "inactivation", "of", "tumor", "suppressors", "commonly", "occur", "in", "many", "human", "cancers"], "h": {"id": "C1705590", "name": "C1705590#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [8, 9]}}
{"token": ["C0077656#ent", "<e1>", ":", "cytochrome", "c", "oxidoreductase", "complex", "III", "and", "ATP", "synthase", "complex", "V", "are", "important", "C3541394#ent", "<e2>", "in", "the", "mitochondrial", "electron", "transport", "chain"], "h": {"id": "C0077656", "name": "C0077656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}}
{"token": ["Mating", "type", "C0017373#ent", "<e1>", "in", "Saccharomyces", "cerevisiae", "initiates", "when", "C0014230#ent", "<e2>", "a", "double-stranded", "DNA", "break", "the", "yeast", "MAT", "locus", "."], "h": {"id": "C0017373", "name": "C0017373#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014230", "name": "C0014230#ent", "pos": [9, 10]}}
{"token": ["Mating", "type", "C0017373#ent", "<e1>", "in", "Saccharomyces", "cerevisiae", "initiates", "when", "C0014230#ent", "<e2>", "a", "site-specific", "double-stranded", "break", "at", "MAT", ",", "the", "yeast", "mating", "type", "locus", "."], "h": {"id": "C0017373", "name": "C0017373#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014230", "name": "C0014230#ent", "pos": [9, 10]}}
{"token": ["Association", "mapping", "the", "candidate", "genes", "implicated", "by", "these", "markers", "in", "937", "UK", "trio", "families", "modestly", "associated", "haplotypes", "in", "C1416525#ent", "<e1>", "(", "p=0.019", ")", "on", "chromosome", "20p12.2", "and", "C1418760#ent", "<e2>", "(", "p=0.003", ")", "on", "chromosome", "11q23.1"], "h": {"id": "C1416525", "name": "C1416525#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1418760", "name": "C1418760#ent", "pos": [27, 28]}}
{"token": ["We", "show", "that", "IFN-gamma", "stimulates", "C1540292#ent", "<e1>", "expression", "on", "APC", "subsets", "and", "abates", "their", "C1423842#ent", "<e2>", "polarization", "capacity", "in", "a", "B7-H1-dependent", "manner", "."], "h": {"id": "C1540292", "name": "C1540292#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [14, 15]}}
{"token": ["However", ",", "C0812246#ent", "<e1>", "was", "completely", "insensitive", "to", "C0001486#ent", "<e2>", "(", "no", "positives", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [8, 9]}}
{"token": ["In", "this", "study", "we", "show", "that", "14.7", "K", "suppresses", "C0812246#ent", "<e1>", "cytolysis", "independently", "of", "C0001486#ent", "<e2>"], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [14, 15]}}
{"token": ["Considering", "the", "known", "involvement", "of", "MAP", "kinase", "pathway", "NF-kappaB", "activation", "that", "of", "12(S)-HETE", "in", "MAP", "kinase", "pathway", "C3539672#ent", "<e1>", "present", "in", "prostate", "cancer", "tissues", "may", "contribute", "to", "the", "C0907533#ent", "<e2>", "activation", "of", "NF-kappaB", "in", "prostate", "cancer", "cells", "."], "h": {"id": "C3539672", "name": "C3539672#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [28, 29]}}
{"token": ["C0542052#ent", "<e1>", "a", "pathophysiologic", "state", "can", "initiate", "lethal", "cardiac", "arrhythmias", "the", "absence", "of", "C1442837#ent", "<e2>"], "h": {"id": "C0542052", "name": "C0542052#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1442837", "name": "C1442837#ent", "pos": [13, 14]}}
{"token": ["Recent", "studies", "suggested", "the", "T-helper", "cells", "type-2", "lymphocytes-specific", "thymus", "and", "activation-regulated", "chemokine", "C1707083#ent", "<e1>", ")", "and", "monocyte-derived", "chemokine", "MDC", ")", "are", "useful", "inflammatory", "markers", "C0877430#ent", "<e2>"], "h": {"id": "C1707083", "name": "C1707083#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0877430", "name": "C0877430#ent", "pos": [24, 25]}}
{"token": ["By", "contrast", ",", "the", "lysosomal", "inhibitor", "C0008269#ent", "<e1>", "and", "the", "C0170168#ent", "<e2>", "U0126", "showed", "no", "effect"], "h": {"id": "C0008269", "name": "C0008269#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [10, 11]}}
{"token": ["To", "map", "the", "antibody", "response", "human", "citrullinated", "C2364020#ent", "<e1>", ",", "a", "candidate", "C1413096#ent", "<e2>", "in", "rheumatoid", "arthritis", "RA", ")", ",", "and", "to", "examine", "cross-reactivity", "with", "bacterial", "enolase", "."], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [12, 13]}}
{"token": ["The", "major", "products", "formed", "are", "the", "epoxide-derived", "C1260386#ent", "<e1>", "conjugates", "2-(S-glutathionyl", ")", "acetyl", "glutathione", "B", "]", "and", "C0763432#ent", "<e2>", "C", "]", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0763432", "name": "C0763432#ent", "pos": [17, 18]}}
{"token": ["Sequence", "analysis", "that", "p14", "is", "the", "basic", "nucleic", "acid-binding", "protein", "entirely", "from", "gag", ",", "and", "C3470427#ent", "<e1>", "is", "a", "product", "of", "the", "pro", "gene", "has", "characteristic", "sequences", "C0030946#ent", "<e2>", "."], "h": {"id": "C3470427", "name": "C3470427#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [27, 28]}}
{"token": ["alpha-Catenin", "enhanced", "GTPgammaS", "binding", "C1412511#ent", "<e1>", "in", "vitro", "the", "presence", "of", "C1540205#ent", "<e2>", "."], "h": {"id": "C1412511", "name": "C1412511#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1540205", "name": "C1540205#ent", "pos": [11, 12]}}
{"token": ["Ryanodine", "is", "a", "selective", "ryanodine", "receptor", "C1419778#ent", "<e1>", ")", "C0001641#ent", "<e2>", ",", "with", "binding", "dependent", "on", "C1419778#ent", "<e1>", "opening", "."], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1419778", "name": "C1419778#ent", "pos": [6, 7]}}
{"token": ["When", "T", "cells", "mixed", "with", "C0162832#ent", "<e1>", "pulsed", "with", "C2347243#ent", "<e2>", "for", "90", "min", "at", "37", "C", ",", "a", "significant", "increase", "in", "T", "cell", "was", "observed", "within", "one", "second", "."], "h": {"id": "C0162832", "name": "C0162832#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2347243", "name": "C2347243#ent", "pos": [9, 10]}}
{"token": ["A", "51-year-old", "man", "with", "C0019693#ent", "<e1>", "highly", "active", "antiretroviral", "therapy", "with", "abdominal", "pain", "C0231807#ent", "<e2>"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0231807", "name": "C0231807#ent", "pos": [13, 14]}}
{"token": ["The", "paper", "presents", "semiotics", "of", "the", "following", "tropical", "subcutaneous", "mycoses", ":", "sporotrichosis", ",", "chromoblastomycosis", ",", "C0024449#ent", "<e1>", ",", "pheohyphomycosis", ",", "zygomycosis", "and", "C0152066#ent", "<e2>", "."], "h": {"id": "C0024449", "name": "C0024449#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0152066", "name": "C0152066#ent", "pos": [22, 23]}}
{"token": ["C1100924#ent", "<e1>", "reduced", "intracellular", "levels", "of", "GSH", ";", "this", "reduction", "was", "abrogated", "only", "by", "C0003402#ent", "<e2>", "Vit", "C.", "However", ",", "C1100924#ent", "<e1>", "did", "not", "promote", "ROS", "generation", "."], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1100924", "name": "C1100924#ent", "pos": [0, 1]}}
{"token": ["The", "blocking", "activity", "of", "GMX", "was", "inhibited", "by", "treatment", "with", "neuraminidase", "and", "C0055091#ent", "<e1>", "not", "by", "treatment", "with", "C1947941#ent", "<e2>", "or", "heat", "(", "100", "degrees", "C", ")", "."], "h": {"id": "C0055091", "name": "C0055091#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [18, 19]}}
{"token": ["C0003290#ent", "<e1>", "particularly", "amitriptyline", ",", "C0013065#ent", "<e2>", ",", "doxepin", ",", "trimipramine", "and", "maprotiline", ",", "should", "be", "avoided", "in", "patients", "at", "risk", "of", "suicide", ",", "whatever", "the", "age", "of", "the", "patient", "."], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013065", "name": "C0013065#ent", "pos": [5, 6]}}
{"token": ["In", "a", "double-blind", "study", "advantages", "of", "a", "once-a-day", "dosage", "of", "a", "C0003290#ent", "<e1>", "against", "a", "thrice", "daily", "dosage", "regimen", "evaluated", "using", "C0013065#ent", "<e2>", "(", "Prothiaden", ")", "and", "matching", "placebo", "tablets", "."], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013065", "name": "C0013065#ent", "pos": [21, 22]}}
{"token": ["Documentation", "of", "the", "immunologic", "responses", "C0936073#ent", "<e1>", "been", "limited", "to", "the", "demonstration", "of", "an", "allergic", "reaction", "C0936073#ent", "<e1>", "by", "skin", "testing", "some", "cases", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [5, 6]}}
{"token": ["This", "isomer", "occurs", "(", "6", "-", "7", "%", ")", "in", "supposedly", "pure", "C0936073#ent", "<e1>", "and", "in", "the", "commercially", "available", "C0936073#ent", "<e1>", "administered", "to", "patients", "for", "induction", "of", "anesthesia", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [12, 13]}}
{"token": ["Right", "cardiac", "catheterization", "studies", "have", "demonstrated", "an", "improvement", "in", "cardiac", "hemodynamics", "patients", "with", "C0018802#ent", "<e1>", "the", "administration", "of", "C0136123#ent", "<e2>", "(", "per", ")", ":", "reduction", "in", "ventricular", "filling", "pressures", "pulmonary", "capillary", "wedge", "pressure", "right", "atrial", "pressure", "and", "systemic", "resistance", "an", "increase", "in", "cardiac", "output"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0136123", "name": "C0136123#ent", "pos": [18, 19]}}
{"token": ["To", "explore", "the", "levels", "of", "soluble", "TRAIL", "and", "DR5", "in", "plasma", "of", "patients", "with", "congestive", "heart", "failure", "C0018802#ent", "<e1>", ")", "and", "the", "effects", "of", "C0136123#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0136123", "name": "C0136123#ent", "pos": [24, 25]}}
{"token": ["In", "C0018802#ent", "<e1>", "patients", "with", "C0136123#ent", "<e2>", "lowered", "mean", "24-h", ",", "day", "and", "night", "BP", "its", "loads", ",", "reestablished", "two-phase", "circadian", "rhythm", "of", "AP", "and", "corrected", "BP", "variability", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0136123", "name": "C0136123#ent", "pos": [5, 6]}}
{"token": ["C0162576#ent", "<e1>", "is", "a", "fish-borne", "C0043528#ent", "<e2>"], "h": {"id": "C0162576", "name": "C0162576#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [5, 6]}}
{"token": ["Anisakiasis", ",", "or", "C0162576#ent", "<e1>", ",", "is", "a", "C0043528#ent", "<e2>", "to", "the", "infestation", "by", "nematodes", "of", "the", "Anisakidae", "family", ",", "mainly", "by", "Anisakis", "simplex"], "h": {"id": "C0162576", "name": "C0162576#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [8, 9]}}
{"token": ["Active", "TGF-beta1", "evoked", "C0812281#ent", "<e1>", "generation", "and", "stimulated", "C0051844#ent", "<e2>", "mRNA", "and", "p53", "protein", "expression", ",", "whereas", "a", "superoxide", "scavenger", "inhibitors", "of", "nicotinamide", "adenine", "dinucleotide", "oxidase", "p38", "mitogen-activated", "protein", "kinase", "p38", "MAPK", "abolished", "the", "TGF-beta1", "effect", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [8, 9]}}
{"token": ["SUR-5", "also", "has", "some", "sequence", "similarity", "C0009227#ent", "<e1>", "is", "predicted", "to", "contain", "ATP/GTP", "and", "C4285220#ent", "<e2>", "binding", "sites"], "h": {"id": "C0009227", "name": "C0009227#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4285220", "name": "C4285220#ent", "pos": [14, 15]}}
{"token": ["Crystal", "structures", "two", "ATP-dependent", "DNA", "ligases", "an", "NAD+-dependent", "DNA", "ligase", ",", "and", "an", "ATP-dependent", "RNA", "ligase", "how", "C0009227#ent", "<e1>", "utilize", "the", "C4285220#ent", "<e2>", "group", "and", "their", "multi-domain", "architectures", "to", "manipulate", "nucleic", "acid", "structure", "catalyze", "the", "end-joining", "reaction", "."], "h": {"id": "C0009227", "name": "C0009227#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4285220", "name": "C4285220#ent", "pos": [21, 22]}}
{"token": ["The", "disorder", "seems", "to", "be", "a", "variant", "of", "the", "C0393576#ent", "<e1>", "and", "the", "pathology", "may", "account", "for", "evidence", "of", "C0242422#ent", "<e2>", "and", "amyotrophy", "in", "that", "syndrome", "."], "h": {"id": "C0393576", "name": "C0393576#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [19, 20]}}
{"token": ["C1416508#ent", "<e1>", "shares", "highly", "conserved", "exon", "size", "intron-exon", "borders", "with", "other", "ITI", "C1420192#ent", "<e2>"], "h": {"id": "C1416508", "name": "C1416508#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "our", "results", "demonstrate", "the", "involvement", "of", "C1421249#ent", "<e1>", "protein", "kinase", "C", "this", "specific", "C1861303#ent", "<e2>", "activation", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1861303", "name": "C1861303#ent", "pos": [15, 16]}}
{"token": ["At", "1.4", "X", "10(-3", ")", "M", "C0018549#ent", "<e1>", "the", "catecholamine", "release", "induced", "by", "C0242898#ent", "<e2>", "GABA", ")", "was", "inhibited", "by", "40", "%", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [13, 14]}}
{"token": ["We", "demonstrate", "that", "C1705778#ent", "<e1>", "interacts", "directly", "with", "c-Jun", "N-terminal", "kinase", "1", "C1367731#ent", "<e2>", ")", "."], "h": {"id": "C1705778", "name": "C1705778#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [12, 13]}}
{"token": ["C0009450#ent", "<e1>", "as", "frequently", "as", "pneumonia", "or", "C0042029#ent", "<e2>"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [7, 8]}}
{"token": ["C0009450#ent", "<e1>", "are", "associated", "with", "pneumonia", "or", "urinary", "tract", "infection", "C0042029#ent", "<e2>", ")", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "this", "paper", "is", "to", "study", "the", "influence", "of", "salmon", "calcitonin", "SCT", ")", "on", "C0002772#ent", "<e1>", "opioid", "transduction", "pathways", "functionally", "uncoupled", "from", "Gi/o", "proteins", "by", "treatment", "with", "C0043167#ent", "<e2>", "PTX", ")", "."], "h": {"id": "C0002772", "name": "C0002772#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [29, 30]}}
{"token": ["In", "addition", ",", "many", "patients", "with", "C0752347#ent", "<e1>", "are", "hypersensitive", "to", "neuroleptics", ",", "which", "can", "induce", "severe", "C0015371#ent", "<e2>", "and", "other", "symptoms", "--", "sometimes", "ending", "in", "death", "."], "h": {"id": "C0752347", "name": "C0752347#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [17, 18]}}
{"token": ["The", "activated", "IL-1", "receptor", "complex", "which", "consists", "of", "the", "IL-1", "receptor", "type", "I", "the", "C1327771#ent", "<e1>", "IL-1RAcP", ")", ",", "generates", "multiple", "cellular", "responses", "including", "C1417708#ent", "<e2>", "IL-2", "secretion", ",", "and", "IL-2", "promoter", "activation"], "h": {"id": "C1327771", "name": "C1327771#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [24, 25]}}
{"token": ["Expression", "of", "a", "dominant-negative", "mutant", "of", "c-Jun", "NH(2)-terminal", "kinase", "C1367731#ent", "<e1>", ")", "suppressed", "glucose", "deprivation-induced", "C1367731#ent", "<e1>", "activation", ",", "C1705342#ent", "<e1>", ",", "and", "alteration", "of", "paxillin", "."], "h": {"id": "C1367731", "name": "C1367731#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705342", "name": "C1705342#ent", "pos": [19, 20]}}
{"token": ["When", "C3274839#ent", "<e1>", "was", "progressing", "while", "C0175697#ent", "<e2>", "was", "decreasing", "year", "after", "year", ",", "LTS", "has", "been", "improved", "since", "the", "late", "1970s", "."], "h": {"id": "C3274839", "name": "C3274839#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [6, 7]}}
{"token": ["Rhodococcus", "equi", "C0000833#ent", "<e1>", "occur", "in", "immunocompromised", "patients", "with", "prolonged", "and", "refractory", "C0024116#ent", "<e2>"], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024116", "name": "C0024116#ent", "pos": [12, 13]}}
{"token": ["USA", "91", ",", "12120", "-", "12124", ")", ",", "was", "twofold", "higher", "with", "mutant", "C1415761#ent", "<e1>", "at", "4", "degrees", "C", "than", "with", "wild-type", "C1415761#ent", "<e1>", ",", "and", "was", "C2744579#ent", "<e1>", "dependent", "."], "h": {"id": "C1415761", "name": "C1415761#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "the", "proteolytic", "activity", "inhibited", "by", "diisopropylfluorophosphate", "but", "was", "not", "affected", "by", "C0013618#ent", "<e1>", ",", "indicating", "that", "this", "enzyme", "is", "a", "C2717971#ent", "<e2>"], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [22, 23]}}
{"token": ["The", "C0033681#ent", "<e1>", "is", "a", "key", "C1422492#ent", "<e2>", "of", "Src", "in", "many", "cells", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [6, 7]}}
{"token": ["They", "are", "the", "interaction", "between", "C0031656#ent", "<e1>", "Leishmania", "and", "drug", "suramin", "C1417092#ent", "<e2>", "Trichinella", "and", "drug", "closantel", "."], "h": {"id": "C0031656", "name": "C0031656#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417092", "name": "C1417092#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "present", "a", "patient", "with", "a", "subtelomeric", "deletion", "4p16.3", "showing", "growth", "and", "psychomotor", "delay", "a", "typical", "C1956097#ent", "<e1>", "facial", "appearance", "and", "two", "episodes", "of", "C0036572#ent", "<e2>", "in", "conjunction", "with", "fever", "."], "h": {"id": "C1956097", "name": "C1956097#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [25, 26]}}
{"token": ["C1956097#ent", "<e1>", "characterized", "by", "severe", "growth", "and", "mental", "retardation", "microcephaly", ",", "C0036572#ent", "<e2>", "and", "'", "Greek", "helmet", "'", "facies", ",", "caused", "by", "partial", "deletion", "of", "the", "short", "arm", "of", "chromosome", "4"], "h": {"id": "C1956097", "name": "C1956097#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [11, 12]}}
{"token": ["Ionizing", "radiation", "phosphorylation", "of", "C1419619#ent", "<e1>", "on", "Thr21", "was", "defective", "in", "ATM-deficient", "cells", ",", "while", "C0594375#ent", "<e2>", "(CPT)-induced", "phosphorylation", "of", "C1419619#ent", "<e1>", "on", "Thr21", "was", "defective", "in", "cells", "lacking", "functional", "DNA-PK", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419619", "name": "C1419619#ent", "pos": [4, 5]}}
{"token": ["Here", ",", "we", "show", "that", "amyloid", "proteins", "beta", "2-m", "and", "C0238239#ent", "<e1>", "immunoglobulins", ",", "were", "degraded", "by", "C0041236#ent", "<e2>", "."], "h": {"id": "C0238239", "name": "C0238239#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [17, 18]}}
{"token": ["The", "orthostatic", "index", "reduced", "after", "prazosin", "and", "C0022860#ent", "<e1>", "by", "about", "24", "%", ",", "after", "C0018318#ent", "<e2>", "by", "about", "30", "%", ",", "and", "after", "carvedilol", "by", "about", "13", "%", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018318", "name": "C0018318#ent", "pos": [15, 16]}}
{"token": ["This", "procedure", "was", "repeated", "on", "separate", "occasions", "after", "pretreatment", "of", "the", "patients", "with", "blocking", "dosages", "of", "propranolol", ",", "C0022860#ent", "<e1>", ",", "phenoxybenzamine", "and", "C0018318#ent", "<e2>", "respectively", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0018318", "name": "C0018318#ent", "pos": [23, 24]}}
{"token": ["Inhibition", "of", "alpha", "stimulation", "been", "found", "with", "C0022860#ent", "<e1>", ",", "to", "a", "small", "degree", "with", "C0065863#ent", "<e2>", "and", "carvedilol", ",", "and", "has", "been", "suggested", "with", "celiprolol", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0065863", "name": "C0065863#ent", "pos": [15, 16]}}
{"token": ["The", "levels", "of", "endogenous", "C3887648#ent", "<e1>", "(", "NA", ")", "in", "rat", "C0036091#ent", "<e2>", "reduced", "to", "about", "40", "per", "cent", "after", "1", "hour", "of", "preganglionic", "stimulation", "4", "Hz", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [11, 12]}}
{"token": ["The", "mechanism", "by", "which", "either", "LMP1", "expression", "or", "CD40", "ligation", "C1334122#ent", "<e1>", "production", "was", "found", "to", "be", "C2986464#ent", "<e2>", "."], "h": {"id": "C1334122", "name": "C1334122#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [17, 18]}}
{"token": ["Xeroderma", "pigmentosum", "XP", ")", "and", "trichothiodystrophy", "(", "C2983123#ent", "<e1>", ")", "are", "rare", "C0037274#ent", "<e2>", "transmitted", "as", "recessive", "and", "autosomal", "traits", "that", "result", "in", "reduced", "capacity", "to", "repair", "UV-induced", "DNA", "lesions", "."], "h": {"id": "C2983123", "name": "C2983123#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [12, 13]}}
{"token": ["The", "resulting", "tryptic", "fragments", "326", "and", "307", "C3539946#ent", "<e1>", "length", "and", "retain", "their", "ability", "to", "react", "with", "C0011854#ent", "<e2>", "sera", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "the", "effect", "of", "epinephrine", "on", "the", "circulating", "C3539946#ent", "<e1>", "we", "infused", "epinephrine", "into", "normal", "human", "subjects", "and", "C0011854#ent", "<e2>", "diabetic", "patients", "given", "a", "constant", "basal", "infusion", "of", "insulin", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [19, 20]}}
{"token": ["The", "percentage", "of", "small", "C0340427#ent", "<e1>", "was", "also", "higher", "in", "the", "animals", "C0342895#ent", "<e2>", "the", "starch", "diet", "to", "animals", "fed", "the", "sucrose", "diet", "P", "less", "than", "0.01", ")", "."], "h": {"id": "C0340427", "name": "C0340427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "among", "women", "with", "similar", "exposure", "to", "chlamydiae", ",", "the", "serologic", "response", "C1415790#ent", "<e1>", "exhibited", "a", "stronger", "correlation", "with", "C3538698#ent", "<e2>", "than", "did", "the", "response", "to", "Hsp60", "or", "MOMP", "."], "h": {"id": "C1415790", "name": "C1415790#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3538698", "name": "C3538698#ent", "pos": [20, 21]}}
{"token": ["C3541407#ent", "<e1>", "such", "as", "formic", ",", "C0981805#ent", "<e2>", ",", "phenylpropionic", ",", "anisic", ",", "and", "para-methoxylphenylactic", "acids", ",", "were", "investigated", "."], "h": {"id": "C3541407", "name": "C3541407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0981805", "name": "C0981805#ent", "pos": [6, 7]}}
{"token": ["The", "effects", "of", "nomifensine", "were", "antagonized", "by", "C0038803#ent", "<e1>", "(", "1", "microM", ")", ",", "a", "C3850099#ent", "<e2>"], "h": {"id": "C0038803", "name": "C0038803#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [15, 16]}}
{"token": ["Neither", "C0038803#ent", "<e1>", "(", "D2", "receptor", "antagonist", "nor", "quinpirole", "(", "C3850099#ent", "<e2>", "had", "a", "significant", "effect", "."], "h": {"id": "C0038803", "name": "C0038803#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [10, 11]}}
{"token": ["As", "a", "result", "of", "our", "experience", "we", "have", "revised", "our", "indications", "for", "bilateral", "nephrectomy", "now", "are", "C0520575#ent", "<e1>", "only", "when", "associated", "with", "persistent", "bacteriuria", "or", "C0017168#ent", "<e2>", "polycystic", "kidneys", "uncontrollable", "hypertension", "."], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [25, 26]}}
{"token": ["The", "carnitine", "transporter", "defect", "McKusick", "212140", ")", "is", "an", "C3899988#ent", "<e1>", "by", "mutations", "in", "the", "C1420134#ent", "<e2>", "which", "encodes", "the", "high-affinity", "carnitine", "transporter", "OCTN2", "(", "Wang", "et", "al", "2001", ")", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420134", "name": "C1420134#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "C0070915#ent", "<e1>", "potently", "inhibited", "the", "hypertensive", "effect", "of", "big", "C3273437#ent", "<e2>", "without", "affecting", "the", "ET-1-induced", "hypertension", "in", "anesthetized", "rats", "."], "h": {"id": "C0070915", "name": "C0070915#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [11, 12]}}
{"token": ["This", "C1412362#ent", "<e1>", "was", "used", "clinically", "to", "C0017343#ent", "<e2>", "the", "fibrotic", "brachial", "plexus", "neurolysis", ",", "in", "the", "treatment", "of", "a", "pain", "syndrome", "which", "several", "simple", "neurolyses", "had", "previously", "failed", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017343", "name": "C0017343#ent", "pos": [7, 8]}}
{"token": ["The", "C3887967#ent", "<e1>", "two", "abnormal", "proteins", ":", "the", "C1709412#ent", "<e2>", "an", "abnormal", "PML", "protein", "the", "RAR", "alpha/PML", "gene", "encodes", "the", "RAR", "alpha/PML", "fusion", "protein", "."], "h": {"id": "C3887967", "name": "C3887967#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1709412", "name": "C1709412#ent", "pos": [8, 9]}}
{"token": ["P.", "niruri", "significantly", "reduced", "the", "elevated", "C1415274#ent", "<e1>", "GPT", ")", "and", "alkaline", "phosphatase", "C1706468#ent", "<e2>", ")", "levels", "in", "the", "sera", "of", "toxicity", "induced", "mice", ",", "compared", "with", "the", "control", "group"], "h": {"id": "C1415274", "name": "C1415274#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706468", "name": "C1706468#ent", "pos": [13, 14]}}
{"token": ["Mild", "abnormal", "laboratory", "findings", "were", "observed", "in", "2", "patients", ":", "elevation", "of", "C1415274#ent", "<e1>", ",", "gamma-GTP", ",", "BUN", "and", "elevation", "of", "C1706468#ent", "<e2>", "."], "h": {"id": "C1415274", "name": "C1415274#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706468", "name": "C1706468#ent", "pos": [21, 22]}}
{"token": ["C0013595#ent", "<e1>", "AE", ")", "is", "a", "major", "risk", "factor", "C0239816#ent", "<e2>"], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0239816", "name": "C0239816#ent", "pos": [9, 10]}}
{"token": ["To", "survey", "the", "prevalence", "of", "asthma", ",", "C0013595#ent", "<e1>", "conjunctivitis", ",", "hay", "fever/rhinitis", ",", "and", "C0239816#ent", "<e2>", "dental", "personnel", "a", "questionnaire", "was", "distributed", "to", "all", "dental", "teams", "Northern", "Sweden"], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0239816", "name": "C0239816#ent", "pos": [15, 16]}}
{"token": ["Seventy-six", "patients", "with", "C0017612#ent", "<e1>", "ocular", "hypertension", "randomly", "assigned", "to", "receive", "either", "C0005320#ent", "<e2>", "0.5", "%", "or", "dipivefrin", "0.1", "%", "."], "h": {"id": "C0017612", "name": "C0017612#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0005320", "name": "C0005320#ent", "pos": [12, 13]}}
{"token": ["Earlier", "episodes", "of", "C0266924#ent", "<e1>", "consisted", "of", "1/4", "of", "the", "indications", "and", "C0333519#ent", "<e2>", "or", "pulpitis", "of", "the", "third", "molar", "up", "13", "%", "."], "h": {"id": "C0266924", "name": "C0266924#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0333519", "name": "C0333519#ent", "pos": [12, 13]}}
{"token": ["The", "Drosophila", "gene", "is", "highly", "homologous", "to", "the", "major", "yeast", "exoribonuclease", "C1173619#ent", "<e1>", "and", "is", "the", "only", "known", "C1538124#ent", "<e2>", "eukaryotes", "."], "h": {"id": "C1173619", "name": "C1173619#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1538124", "name": "C1538124#ent", "pos": [18, 19]}}
{"token": ["C0123091#ent", "<e1>", "was", "successfully", "combined", "with", "mood", "stabilizers", "particularly", "C0060926#ent", "<e2>", ",", "in", "patients", "with", "prominent", "affective", "instability", "."], "h": {"id": "C0123091", "name": "C0123091#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0060926", "name": "C0060926#ent", "pos": [9, 10]}}
{"token": ["MAP", "kinase", "cascade", "activated", "by", "ras", ",", "70kDaS6", "kinase", "lying", "downstream", "of", "C2713509#ent", "<e1>", ",", "and", "the", "regulation", "of", "C0017932#ent", "<e2>", "been", "discussed", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [19, 20]}}
{"token": ["The", "most", "common", "abnormalities", "found", "in", "adult", "animals", "(", "12", "males", "and", "20", "females", ")", "of", "the", "transgenic", "line", "inflammatory", "processes", "including", "pancreatitis", ",", "C0019159#ent", "<e1>", ",", "sialoadenitis", "and", "C0520575#ent", "<e2>", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0520575", "name": "C0520575#ent", "pos": [29, 30]}}
{"token": ["C0023264#ent", "<e1>", "a", "heterogenous", "neurologic", "disease", "by", "C0036572#ent", "<e2>", ",", "developmental", "delay", "muscle", "weakness", "respiratory", "abnormalities", "optic", "abnormalities", "including", "atrophy", "and", "ophthalmoplegia", ",", "and", "progressive", "cranial", "nerve", "degeneration", "with", "early", "onset", "infants", "and", "children", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [7, 8]}}
{"token": ["Recent", "studies", "have", "demonstrated", "that", "this", "C0014442#ent", "<e1>", "is", "inhibited", "by", "C0673968#ent", "<e2>", "(", "Morikis", ",", "D.", ",", "Assa-Munt", ",", "N.", ",", "Sahu", ",", "A.", ",", "Lambris", ",", "J.D.", ",", "1998", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0673968", "name": "C0673968#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "C0079068#ent", "<e1>", "knockout", "fibroblasts", "refractory", "to", "transformation", "by", "C3853557#ent", "<e2>", ",", "consistent", "with", "requirement", "for", "c-Myc", "protein", "v-Src", "transformation", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3853557", "name": "C3853557#ent", "pos": [10, 11]}}
{"token": ["Initial", "experiments", "demonstrated", "that", "uptake", "of", "C1418251#ent", "<e1>", "by", "voltage-clamped", "Xenopus", "laevis", "oocytes", "expressing", "C1420141#ent", "<e2>", "led", "to", "net", "entry", "of", "positive", "charge", "suggesting", "that", "coupling", "was", "one-to-one", "."], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420141", "name": "C1420141#ent", "pos": [14, 15]}}
{"token": ["In", "all", "patients", "a", "distinct", "improvement", "in", "both", "anxiety", "and", "C0086132#ent", "<e1>", "observed", "under", "the", "C1254351#ent", "<e2>"], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["HP", "participants", "showed", "reduced", "alcohol", ",", "family", ",", "and", "psychiatric", "severity", "and", "reduced", "C0086132#ent", "<e1>", "while", "LP", "subjects", "showed", "reduced", "C1254351#ent", "<e2>", ",", "self-debasing", ",", "and", "acting-out", "problems", "."], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [20, 21]}}
{"token": ["Here", "we", "report", "on", "DFNB59", ",", "a", "newly", "identified", "C0079429#ent", "<e1>", "on", "chromosome", "2q31.1-q31.3", "in", "four", "families", "segregating", "C2732267#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2732267", "name": "C2732267#ent", "pos": [18, 19]}}
{"token": ["Both", "strains", "are", "primarily", "leptin", "resistant", "due", "to", "a", "C1366515#ent", "<e1>", "ZDF", "rats", ",", "however", ",", "develop", "type-2", "like", "C0011849#ent", "<e2>", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [19, 20]}}
{"token": ["The", "clinical", "features", "of", "EPTS", "and", "the", "chromosomal", "localization", "the", "respective", "gene", "in", "the", "same", "region", "as", "MYH9", "suggest", "that", "this", "disorder", "is", "C0002085#ent", "<e1>", "with", "the", "other", "C0017547#ent", "<e2>", "platelet", "disorders"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [28, 29]}}
{"token": ["In", "1956", "Rolf", "C1853118#ent", "<e1>", "reported", "on", "six", "children", "with", "severe", "C0027947#ent", "<e2>", "associated", "with", "block", "in", "myelopoiesis", "at", "the", "promyelocyte/myelocyte", "stage", "and", "an", "autosomal", "recessive", "inheritance", "."], "h": {"id": "C1853118", "name": "C1853118#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [11, 12]}}
{"token": ["Immunoblot", "assay", "that", ",", "accompanying", "the", "increase", "in", "hepatic", "GST", "activity", ",", "GO", ",", "DADS", ",", "DAS", "(", "80", "mg/kg", "body", "weight", "and", "C0002395#ent", "<e1>", "increased", "the", "expression", "of", "GST", "Ya", "C2985446#ent", "<e2>", "and", "Yc", "proteins"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2985446", "name": "C2985446#ent", "pos": [31, 32]}}
{"token": ["Our", "results", "show", "that", "bemetizide", "as", "a", "C0012802#ent", "<e1>", "acts", "in", "the", "diluting", "segments", "of", "the", "C0722058#ent", "<e2>", "."], "h": {"id": "C0012802", "name": "C0012802#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0722058", "name": "C0722058#ent", "pos": [16, 17]}}
{"token": ["To", "confirm", "that", "palmitoylation", "was", "occurring", "on", "C2717970#ent", "<e1>", "in", "the", "N-terminal", "region", "of", "C1442788#ent", "<e2>", ",", "site-directed", "mutagenesis", "used", "to", "replace", "the", "C2717970#ent", "<e1>", "at", "positions", "3", "and", "6", "with", "alanine", "."], "h": {"id": "C1442788", "name": "C1442788#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [7, 8]}}
{"token": ["The", "results", "were", "expected", "to", "lay", "foundation", "for", "further", "studies", "on", "the", "C0599220#ent", "<e1>", "DNA", "vaccine", "MPB83", "gene", "in", "their", "prevention", "against", "C0041296#ent", "<e2>"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [22, 23]}}
{"token": ["C1442757#ent", "<e1>", "technique", "has", "been", "successfully", "tested", "experimentally", "on", "C1971775#ent", "<e2>", "."], "h": {"id": "C1442757", "name": "C1442757#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1971775", "name": "C1971775#ent", "pos": [9, 10]}}
{"token": ["Nine", "patients", "(", "40.9", "%", ")", "presented", "C0018799#ent", "<e1>", "myocardial", "infarction", "three", "and", "C0577698#ent", "<e2>", "six", ")", ",", "one", "(", "4.5", "%", ")", "presented", "hypertensive", "cardiopathy"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0577698", "name": "C0577698#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "there", "was", "no", "difference", "in", "the", "therapeutic", "response", "maprotiline", "or", "to", "C0063448#ent", "<e1>", "between", "the", "patients", "with", "high", "and", "low", "plasma", "C0032483#ent", "<e2>", "levels", "before", "treatment", "."], "h": {"id": "C0063448", "name": "C0063448#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [23, 24]}}
{"token": ["Cyclic", "infectious", "diseases", "particularly", "reliable", "immunity", "are", "certain", "C0042769#ent", "<e1>", "such", "as", "measles", ",", "poliomyelitis", "and", "C0043395#ent", "<e2>"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0043395", "name": "C0043395#ent", "pos": [16, 17]}}
{"token": ["Sulfate", "is", "required", "for", "detoxification", "of", "xenobiotics", "such", "as", "C2917659#ent", "<e1>", "(", "APAP", ")", ",", "a", "leading", "cause", "of", "C0162557#ent", "<e2>", "humans", "."], "h": {"id": "C2917659", "name": "C2917659#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [19, 20]}}
{"token": ["To", "investigate", "this", "question", ",", "we", "overexpressed", "plasminogen", "activator", "inhibitor-1", "PAI-1", ")", ",", "an", "inhibitor", "of", "t-PA", "and", "C1706177#ent", "<e1>", ",", "in", "a", "rat", "model", "of", "C0003486#ent", "<e2>"], "h": {"id": "C1706177", "name": "C1706177#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [26, 27]}}
{"token": ["Takayasu's", "disease", "an", "C4025222#ent", "<e1>", "often", "progresses", "to", "stenosis", "or", "C0751003#ent", "<e2>", "of", "the", "large", "arteries", "of", "the", "aortic", "arch"], "h": {"id": "C4025222", "name": "C4025222#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [10, 11]}}
{"token": ["The", "inhibitory", "effects", "of", "5b", ",", "5d", ",", "C2681642#ent", "<e1>", ",", "and", "7d", "on", "C1333327#ent", "<e2>", "rabbit", "thymus", "thymidine", "kinase", "evaluated", "."], "h": {"id": "C2681642", "name": "C2681642#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333327", "name": "C1333327#ent", "pos": [14, 15]}}
{"token": ["In", "the", "presence", "of", "C1335268#ent", "<e1>", "the", "activation", "of", "C1826724#ent", "<e2>", "enhanced", "the", "phosphorylation", "of", "Connexin", "43", "by", "four-fold", "compared", "to", "the", "absence", "of", "C1335268#ent", "<e1>", "."], "h": {"id": "C1335268", "name": "C1335268#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [9, 10]}}
{"token": ["We", "report", "a", "case", "of", "C0151693#ent", "<e1>", "subsequent", "adrenal", "insufficiency", "a", "laparoscopic", "hysterectomy", "a", "patient", "with", "C0085278#ent", "<e2>"], "h": {"id": "C0151693", "name": "C0151693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085278", "name": "C0085278#ent", "pos": [16, 17]}}
{"token": ["Analysis", "of", "NaDodSO4/PAGE", "fluorograms", "of", "solubilized", "retinas", "and", "rod", "outer", "segment", "ROS", ")", "membranes", "indicated", "a", "relatively", "selective", "effect", "of", "C1413749#ent", "<e1>", "on", "opsin", "(", "the", "rod", "visual", "pigment", "C0072522#ent", "<e2>", ")", "."], "h": {"id": "C1413749", "name": "C1413749#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [29, 30]}}
{"token": ["A", "case", "is", "reported", "of", "C3854173#ent", "<e1>", "by", "bilateral", "ureteral", "obstruction", "from", "extensive", "C0014175#ent", "<e2>"], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014175", "name": "C0014175#ent", "pos": [13, 14]}}
{"token": ["Chimaeric", "proteins", "also", "made", "consisting", "of", "the", "pro-region", "of", "C1418389#ent", "<e1>", "fused", "to", "the", "mature", "portion", "of", "C1704969#ent", "<e2>", "and", "the", "pro-region", "of", "C1704969#ent", "<e2>", "fused", "to", "the", "mature", "region", "of", "C1418389#ent", "<e1>", "."], "h": {"id": "C1704969", "name": "C1704969#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418389", "name": "C1418389#ent", "pos": [9, 10]}}
{"token": ["A", "series", "of", "CD", "measurements", "were", "carried", "out", "on", "members", "of", "C0030956#ent", "<e1>", "in", "the", "C1414260#ent", "<e2>", "and", "sarafotoxin", "families", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414260", "name": "C1414260#ent", "pos": [15, 16]}}
{"token": ["This", "is", "the", "first", "time", "that", "a", "C0030956#ent", "<e1>", "structurally", "unrelated", "to", "C1414260#ent", "<e2>", "or", "VIC", "is", "shown", "to", "block", "the", "binding", "and", "mitogenic", "effects", "of", "peptides", "of", "the", "endothelin", "family"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414260", "name": "C1414260#ent", "pos": [12, 13]}}
{"token": ["Estrogen", "administration", "attenuated", "endotoxin-induced", "C0812246#ent", "<e1>", "expression", "and", "neuronal", "injury", "indicating", "that", "the", "down-regulation", "of", "C0812246#ent", "<e1>", "expression", "plays", "a", "role", "in", "ischemic", "neuroprotection", "by", "C2936882#ent", "<e1>", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [25, 26]}}
{"token": ["Globin", "chain", "synthesis", "DNA", "restriction", "enzyme", "analysis", "that", "the", "unusual", "severity", "of", "heterozygous", "C4274391#ent", "<e1>", "observed", "in", "this", "family", "is", "related", "to", "an", "C0221406#ent", "<e2>", "of", "alpha-globin", "chains", "from", "an", "alpha-globin", "gene", "triplication"], "h": {"id": "C4274391", "name": "C4274391#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [23, 24]}}
{"token": ["In", "this", "study", ",", "we", "have", "used", "fluorescence", "microscopy", "probe", "the", "intracellular", "targeting", "of", "C1424450#ent", "<e1>", "during", "different", "stages", "of", "the", "C0080054#ent", "<e2>", "the", "structural", "features", "are", "important", "for", "C1424450#ent", "<e1>", "localization", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1424450", "name": "C1424450#ent", "pos": [14, 15]}}
{"token": ["Hence", ",", "the", "use", "of", "C1420234#ent", "<e1>", "inhibitors", "may", "reduce", "reflexly", "mediated", "respiratory", "depression", "C2926735#ent", "<e2>", "of", "apnea", "in", "the", "neonatal", "period", "."], "h": {"id": "C1420234", "name": "C1420234#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [14, 15]}}
{"token": ["C0087093#ent", "<e1>", "was", "extracted", "using", "C0054275#ent", "<e2>", "derivatized", "using", "trifluoroacetic", "anhydride", "butyl", "acetate"], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054275", "name": "C0054275#ent", "pos": [5, 6]}}
{"token": ["Rats", "were", "injected", "with", "various", "doses", "of", "lipopolysaccharide", "(", "LPS", ")", "to", "induce", "C0132555#ent", "<e1>", "activity", "and", "were", "later", "anesthetized", "with", "C0022180#ent", "<e2>", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [21, 22]}}
{"token": ["Nonstructural", "protein", "3", "C1860991#ent", "<e1>", ")", "of", "hepatitis", "C", "virus", "HCV", ")", "is", "a", "C1416671#ent", "<e2>", "is", "essential", "for", "processing", "of", "viral", "polyprotein"], "h": {"id": "C1860991", "name": "C1860991#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [14, 15]}}
{"token": ["However", ",", "the", "5-HT1A", "antagonist", "NAN-190", "(", "1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl", "]", "C0031957#ent", "<e1>", ")", "inhibited", "the", "suppressive", "effect", "C0085228#ent", "<e2>", "on", "the", "marble-burying", "."], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085228", "name": "C0085228#ent", "pos": [16, 17]}}
{"token": ["On", "the", "other", "hand", ",", "the", "5-HT1A", "antagonist", "NAN-190", "(", "1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl", "]", "C0031957#ent", "<e1>", ")", "potentiated", "the", "effect", "of", "C0085228#ent", "<e2>", "on", "forced-swimming", "."], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085228", "name": "C0085228#ent", "pos": [19, 20]}}
{"token": ["The", "present", "study", "demonstrates", "that", "all", "nerve", "agents", "produce", "C0038220#ent", "<e1>", "that", "the", "therapeutic", "effectiveness", "C0004259#ent", "<e2>", "and", "biperiden", "roughly", "paralleled", "the", "seizurogenic", "potential", "of", "these", "agents", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [15, 16]}}
{"token": ["The", "'", "in", "vitro", "activity", "of", "ergotamine", ",", "dihydroergocristine", ",", "dihydroergocornine", "and", "C0012290#ent", "<e1>", "on", "the", "C0031640#ent", "<e2>", "low", "and", "high", "Km", "in", "several", "rat", "brain", "areas", "examined", "."], "h": {"id": "C0012290", "name": "C0012290#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [16, 17]}}
{"token": ["Immunoblotting", "and", "gelatinase", "zymography", "that", "DDR2", "in", "RA", "C1705295#ent", "<e1>", ",", "which", "still", "secreted", "C2001899#ent", "<e2>", "MMP-1", ")", "in", "vitro", "were", "in", "active", "form"], "h": {"id": "C1705295", "name": "C1705295#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "the", "prevalence", "of", "angiographically", "significant", "coronary", "artery", "disease", "CAD", ")", "and", "its", "relation", "to", "C0002962#ent", "<e1>", "coronary", "risk", "factors", "severe", "isolated", "C1883524#ent", "<e2>", "patients", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1883524", "name": "C1883524#ent", "pos": [23, 24]}}
{"token": ["This", "antibiotic", "was", "degraded", "to", "a", "lower", "extent", "than", "was", "cephalothin", ",", "cephaloridine", ",", "and", "C1707322#ent", "<e1>", ",", "whereas", "cefoxitin", "remained", "unaffected", "by", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C1707322", "name": "C1707322#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [24, 25]}}
{"token": ["Hormonal", "evaluation", "C0700502#ent", "<e1>", "the", "patient", "began", "substitution", "therapy", "C1881373#ent", "<e2>", "."], "h": {"id": "C0700502", "name": "C0700502#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1881373", "name": "C1881373#ent", "pos": [9, 10]}}
{"token": ["To", "evaluate", "prospectively", "cardiac", "function", "children", "with", "C0700502#ent", "<e1>", "and", "after", "replacement", "therapy", "C1881373#ent", "<e2>", "."], "h": {"id": "C0700502", "name": "C0700502#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1881373", "name": "C1881373#ent", "pos": [13, 14]}}
{"token": ["The", "toxicity", "of", "C4078840#ent", "<e1>", "to", "hypoxic", "EMT6", "cells", "in", "vitro", "similar", "to", "that", "of", "C0026254#ent", "<e2>", "MC", ")", ":", "the", "aerobic", "toxicity", "of", "C4078840#ent", "<e1>", "was", "considerably", "less", "than", "that", "of", "MC", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4078840", "name": "C4078840#ent", "pos": [3, 4]}}
{"token": ["The", "antineoplastic", "bioreductive", "alkylating", "agent", "C0026254#ent", "<e1>", "when", "activated", "by", "C4078840#ent", "<e2>", "was", "shown", "to", "generate", "both", "hydroxyl", "and", "superoxide", "radicals"], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4078840", "name": "C4078840#ent", "pos": [10, 11]}}
{"token": ["However", ",", "expression", "of", "a", "dominant", "negative", "form", "of", "C1418577#ent", "<e1>", "abolished", "the", "inhibitory", "action", "of", "C1334089#ent", "<e2>", "on", "the", "NOS-2", "promoter", "activity"], "h": {"id": "C1418577", "name": "C1418577#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [16, 17]}}
{"token": ["We", "have", "previously", "identified", "a", "135-kDa", "molecule", "(", "C3539828#ent", "<e1>", ")", "as", "a", "major", "molecular", "partner", "of", "C1413246#ent", "<e2>", "in", "cancer", "cell", "lines"], "h": {"id": "C3539828", "name": "C3539828#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413246", "name": "C1413246#ent", "pos": [17, 18]}}
{"token": ["In", "vitro", "release", "of", "C1332428#ent", "<e1>", "was", "also", "faster", "in", "C1823521#ent", "<e2>", "than", "in", "serum", "."], "h": {"id": "C1332428", "name": "C1332428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [10, 11]}}
{"token": ["B-esterases", "are", "serine", "hydrolases", "of", "cholinesterases", ",", "including", "acetylcholinesterase", "(", "C0234238#ent", "<e1>", ")", "and", "butyrylcholinesterase", "(", "BChE", ")", ",", "and", "C1413347#ent", "<e2>", "(", "CbE", ")", "."], "h": {"id": "C0234238", "name": "C0234238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413347", "name": "C1413347#ent", "pos": [20, 21]}}
{"token": ["In", "the", "group", "of", "C0022658#ent", "<e1>", "the", "sIL-2R", "level", "in", "patients", "with", "rapidly", "progressive", "C0268732#ent", "<e2>", "especially", "higher", "than", "in", "patients", "with", "other", "C0022658#ent", "<e1>"], "h": {"id": "C0268732", "name": "C0268732#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [4, 5]}}
{"token": ["The", "phenotypic", "characteristics", "of", "the", "C1848862#ent", "<e1>", "resemble", "those", "found", "in", "other", "mitochondrial", "(mt)DNA", "disorders", "such", "as", "C0917796#ent", "<e2>", "LHON", ")", "or", "maternally", "inherited", "diabetes", "and", "deafness", "(", "MIDD", ")", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0917796", "name": "C0917796#ent", "pos": [17, 18]}}
{"token": ["The", "C3541407#ent", "<e1>", "renal", "tissue", "biopsy", "0.5", "-", "1", "mg", ")", "obtained", "from", "C0152451#ent", "<e2>", "patients", "were", "analyzed", "capillary", "column", "gas", "chromatography", "mass", "spectrometry"], "h": {"id": "C3541407", "name": "C3541407#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0152451", "name": "C0152451#ent", "pos": [13, 14]}}
{"token": ["When", "compared", "to", "rats", "administered", "C0175697#ent", "<e1>", "alone", ",", "administration", "of", "C0006784#ent", "<e2>", "inhibitor", "prior", "to", "C0175697#ent", "<e1>", "significantly", "reduced", "hepatic", "iNOS", "expression", ",", "hepatic", "neutrophil", "infiltration", "attenuated", "midzonal", "hepatic", "necrosis"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [11, 12]}}
{"token": ["Plasminogen-activator", "inhibitor", "type-2", "C3887675#ent", "<e1>", ")", ",", "a", "serine-proteinase", "inhibitor", "suppresses", "fibrinolysis", "by", "blocking", "both", "C1522670#ent", "<e2>", "and", "tissue-type", "plasminogen", "activators"], "h": {"id": "C3887675", "name": "C3887675#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1522670", "name": "C1522670#ent", "pos": [15, 16]}}
{"token": ["The", "C2699247#ent", "<e1>", "(", "silent", "information", "2", ")", "family", "of", "nicotinamide", "adenine", "C2987244#ent", "<e2>", "been", "implicated", "in", "the", "regulation", "of", "aging", "and", "longevity", "across", "a", "wide", "variety", "of", "organisms", "."], "h": {"id": "C2699247", "name": "C2699247#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987244", "name": "C2987244#ent", "pos": [12, 13]}}
{"token": ["C3540579#ent", "<e1>", "related", "chemokines", "CCL3", "and", "CCL5", "and", "Th2", "related", "C1337091#ent", "<e2>", "as", "ligands", "of", "the", "receptor", "CCR5", "contribute", "to", "disease", "development", "animal", "models", "type", "1", "diabetes"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [10, 11]}}
{"token": ["Subsets", "of", "T", "helper", "cells", "C3540579#ent", "<e1>", "and", "Th2", ",", "induce", "C1337091#ent", "<e2>", "distinct", "patterns", "of", "involvement", "of", "immunoglobulin", "isotypes", "cellular", "immune", "effectors"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [11, 12]}}
{"token": ["The", "initial", "antibiotic", "therapy", "of", "cefotaxime", ",", "gentamicin", ",", "and", "C0025872#ent", "<e1>", ",", "but", "only", "treatment", "with", "ciprofloxacin", "and", "C0541153#ent", "<e2>", "led", "to", "defervescence", "and", "clinical", "stabilization"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0541153", "name": "C0541153#ent", "pos": [19, 20]}}
{"token": ["Of", "14", "commonly", "used", "anticonvulsant", ",", "C0020592#ent", "<e1>", ",", "and", "psychotherapeutic", "drugs", "only", "carbamazepine", "and", "C0024002#ent", "<e2>", "may", "interfere", "with", "analysis", "for", "oxazepam", "or", "N-desmethyldiazepam", ",", "or", "both", "."], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [15, 16]}}
{"token": ["As", "a", "C0020592#ent", "<e1>", ",", "diazepam", "10", "mg", "is", "equivalent", "to", "C0024002#ent", "<e2>", "2.5", "mg", "."], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [11, 12]}}
{"token": ["The", "induced", "leaf", "proteins", "designated", "Rs-AFP3", "and", "Rs-AFP4", ")", "were", "purified", "and", "shown", "to", "be", "C1512488#ent", "<e1>", "to", "seed", "Rs-AFPs", "and", "to", "exert", "similar", "C0003308#ent", "<e2>", "in", "vitro"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [24, 25]}}
{"token": ["However", ",", "separation", "of", "C1538187#ent", "<e1>", "from", "the", "other", "three", "C1417679#ent", "<e2>", "by", "1.5", "Mb", "argues", "that", "C1538187#ent", "<e1>", "may", "be", "under", "autonomous", "control", "."], "h": {"id": "C1538187", "name": "C1538187#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["C0275524#ent", "<e1>", "of", "histamine", "or", "heparin", "significantly", "reduced", "the", "C0055673#ent", "<e2>", "induced", "neutrophil", "accumulation", ",", "whereas", "neither", "histamine", "nor", "heparin", "by", "themselves", "had", "any", "effect", "on", "the", "accumulation", "of", "nucleated", "cells"], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [9, 10]}}
{"token": ["We", "evaluated", "whether", "tranilast", "(", "C0040961#ent", "<e1>", ")", "could", "inhibit", "C0919336#ent", "<e2>", "production", "from", "nasal", "fibroblasts", "response", "to", "tumor", "necrosis", "factor-alpha", "TNF-alpha", ")", "stimulation", "in", "vitro"], "h": {"id": "C0040961", "name": "C0040961#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [10, 11]}}
{"token": ["Subsequent", "analysis", "by", "two-dimensional", "polyacrylamide", "gel", "electrophoresis", "two", "radiolabeled", "C1419015#ent", "<e1>", "were", "identified", "using", "monoclonal", "antibodies", "C8", "and", "C1413029#ent", "<e2>", "."], "h": {"id": "C1419015", "name": "C1419015#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413029", "name": "C1413029#ent", "pos": [18, 19]}}
{"token": ["Increased", "levels", "of", "Proteus", "antibodies", "found", "in", "patients", "with", "rheumatoid", "arthritis", "C0007570#ent", "<e1>", "when", "compared", "to", "normal", "controls", "patients", "with", "C0024141#ent", "<e2>", "and", "sarcoidosis", "."], "h": {"id": "C0007570", "name": "C0007570#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [20, 21]}}
{"token": ["Three", "such", "viruses", "of", "the", "C2985256#ent", "<e1>", "Venezuelan", "equine", "encephalitis", "VEE", ")", ",", "Western", "equine", "encephalitis", "WEE", ")", "and", "C0153065#ent", "<e2>", "EEE", ")", ")", "may", "be", "used", "as", "biological", "warfare", "agents"], "h": {"id": "C2985256", "name": "C2985256#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0153065", "name": "C0153065#ent", "pos": [19, 20]}}
{"token": ["To", "elucidate", "a", "possible", "neural", "function", "vertebrate", "C1334874#ent", "<e1>", ",", "we", "cloned", "and", "characterized", "a", "zebrafish", "homologue", "neogenin", ",", "C1334933#ent", "<e2>", ",", "and", "identified", "four", "alternative", "splice", "sites", "it", "."], "h": {"id": "C1334874", "name": "C1334874#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1334933", "name": "C1334933#ent", "pos": [19, 20]}}
{"token": ["Co-activation", "of", "C0919496#ent", "<e1>", "requires", "amino-terminal", "and", "carboxyl-terminal", "residues", "of", "C1332098#ent", "<e2>", "."], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332098", "name": "C1332098#ent", "pos": [10, 11]}}
{"token": ["The", "data", "suggest", "that", "the", "majority", "of", "patients", "with", "acute", "sporadic", "non-A", ",", "C0019196#ent", "<e1>", ",", "non-C", "hepatitis", "India", "have", "hepatitis", "E.", ",", "C0162557#ent", "<e2>", "sporadic", "nature", "rarely", "from", "hepatitis", "E."], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [23, 24]}}
{"token": ["Most", "patients", "with", "C0019196#ent", "<e1>", "with", "established", "cirrhosis", "and", "complications", "of", "portal", "hypertension", "C0162557#ent", "<e2>"], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [13, 14]}}
{"token": ["The", "other", "compounds", "were", "partial", "agonists", ",", "with", "intrinsic", "activities", "in", "the", "order", "C0015840#ent", "<e1>", "greater", "than", "salbutamol", "greater", "than", "clenbuterol", "greater", "than", "C1412820#ent", "<e2>", "37344", "."], "h": {"id": "C0015840", "name": "C0015840#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412820", "name": "C1412820#ent", "pos": [23, 24]}}
{"token": ["Reduced", "bone", "mass", "be", "postmenopausal", "or", "related", "to", "ovarian", "failure", "type", "I", "osteoporosis", ",", "it", "may", "be", "age-related", "(", "C0029459#ent", "<e1>", ",", "or", "it", "may", "result", "from", "several", "other", "etiologic", "factors", "C0029456#ent", "<e2>", "."], "h": {"id": "C0029459", "name": "C0029459#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0029456", "name": "C0029456#ent", "pos": [31, 32]}}
{"token": ["To", "detect", "mutations", "of", "the", "C0220701#ent", "<e1>", "regulator", "(", "RPGR", ")", "gene", "in", "two", "C0035334#ent", "<e2>", "families", "."], "h": {"id": "C0220701", "name": "C0220701#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [14, 15]}}
{"token": ["The", "neurological", "sequele", "C0342199#ent", "<e1>", "mediated", "by", "thyroid", "hormone", "deficiency", "varying", "from", "minimal", "brain", "function", "a", "C1848862#ent", "<e2>", "of", "severe", "intellectual", "disability"], "h": {"id": "C0342199", "name": "C0342199#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [16, 17]}}
{"token": ["C0026946#ent", "<e1>", "sporotrichosis", ",", "lobomycosis", ",", "rhinosporidiosis", ",", "entomophtoromycoses", ",", "and", "C0008582#ent", "<e2>", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008582", "name": "C0008582#ent", "pos": [11, 12]}}
{"token": ["The", "fact", "that", "no", "cases", "of", "myocardial", "infarction", "observed", "among", "patients", "treated", "with", "beta-adrenergic", "blocking", "drugs", "suggests", "that", "these", "drugs", "may", "have", "a", "\"", "C0007209#ent", "<e1>", "\"", "effect", "on", "ischaemic", "heart", "disease", "patients", "with", "C0085580#ent", "<e2>"], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [34, 35]}}
{"token": ["This", "Review", "focuses", "on", "the", "role", "of", "endogenous", "C0007209#ent", "<e1>", "the", "pathophysiology", "of", "C0085580#ent", "<e2>", "congestive", "heart", "failure", "end-stage", "renal", "disease", "pre-eclampsia", "."], "h": {"id": "C0007209", "name": "C0007209#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [13, 14]}}
{"token": ["Over", "the", "years", ",", "the", "C1538659#ent", "<e1>", "has", "been", "regarded", "as", "C0252902#ent", "<e2>", "regulatory", "function", "cytoskeleton", "reorganization", "motility", "."], "h": {"id": "C1538659", "name": "C1538659#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0252902", "name": "C0252902#ent", "pos": [11, 12]}}
{"token": ["Antimicrobial", "and", "C1516468#ent", "<e1>", "2", "per", "cent", "solution", "of", "C0699305#ent", "<e2>", "in", "40", "per", "cent", "solution", "of", "hexamethylentetramine", "was", "studied", "."], "h": {"id": "C1516468", "name": "C1516468#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0699305", "name": "C0699305#ent", "pos": [9, 10]}}
{"token": ["Adaptive", "immune", "signaling", "be", "coupled", "to", "C0380241#ent", "<e1>", "N-terminal", "kinase", "JNK", ")", "and", "NF-kappaB", "activation", "the", "C0531166#ent", "<e2>", "HPK1", ")", ",", "a", "mammalian", "hematopoiesis-specific", "Ste20", "kinase", "."], "h": {"id": "C0380241", "name": "C0380241#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0531166", "name": "C0531166#ent", "pos": [16, 17]}}
{"token": ["C0102130#ent", "<e1>", "alone", "or", "in", "association", "with", "C0069805#ent", "<e2>", "can", "lower", "the", "urinary", "resistance", "flow", "without", "modifying", "the", "maximum", "urethral", "pressure", "MUP", ")", "."], "h": {"id": "C0102130", "name": "C0102130#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0069805", "name": "C0069805#ent", "pos": [7, 8]}}
{"token": ["Drug", "therapy", "terms", "of", "prophylaxis", "of", "recurrent", "C0403719#ent", "<e1>", "is", "known", "to", "be", "successful", "in", "inborn", "metabolic", "disturbances", "C0019880#ent", "<e2>", ",", "primary", "hyperoxaluria", "inborn", "errors", "purine", "metabolism", "calculi", "due", "to", "urinary", "infection"], "h": {"id": "C0403719", "name": "C0403719#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [18, 19]}}
{"token": ["In", "11", "-", "12", "week-old", "OZR", "and", "LZR", ",", "C0597421#ent", "<e1>", "and", "diuretic", "responses", "to", "intravenously", "administered", "D1", "receptor", "agonist", "C0037239#ent", "<e2>", "3", "microg/kg/min", "for", "30", "min", ")", "were", "measured", "under", "Inactin", "anesthesia"], "h": {"id": "C0597421", "name": "C0597421#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0037239", "name": "C0037239#ent", "pos": [20, 21]}}
{"token": ["In", "terms", "of", "sequencing", ",", "our", "goal", "for", "the", "first", "stage", "is", "to", "characterize", "several", "thousand", "C0339510#ent", "<e1>", "from", "adult", "C0018889#ent", "<e2>", "and", "cysticerci", "cDNA", "libraries", ")", "and", "genomic", "clones"], "h": {"id": "C0339510", "name": "C0339510#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [20, 21]}}
{"token": ["Discriminant", "function", "analysis", "data", "from", "a", "double-blind", "comparative", "trial", "C0023961#ent", "<e1>", "(", "a", "noradrenaline-specific", "reuptake", "inhibitor", "and", "C0016365#ent", "<e2>", "(", "a", "serotonin-specific", "reuptake", "inhibitor", ",", "involving", "183", "patients", "was", "used", "to", "identify", "predictors", "of", "response", "."], "h": {"id": "C0023961", "name": "C0023961#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [17, 18]}}
{"token": ["Two", "classes", "of", "immunophilin", "have", "been", "identified", "with", "C0136073#ent", "<e1>", "(", "CyP", "'s", ")", "being", "proteins", "specifically", "binding", "C0751039#ent", "<e2>", "and", "FKBPs", "specifically", "binding", "FK506"], "h": {"id": "C0136073", "name": "C0136073#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [18, 19]}}
{"token": ["Additions", "of", "purified", "enzymes", "(", "C0032467#ent", "<e1>", "calf", "thymus", "or", "Escherichia", "coli", "with", "E.", "coli", "C0012888#ent", "<e2>", "increased", "the", "joining", "function", "the", "nuclei", "."], "h": {"id": "C0032467", "name": "C0032467#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012888", "name": "C0012888#ent", "pos": [15, 16]}}
{"token": ["C0038868#ent", "<e1>", "PSP", ")", "is", "a", "neurodegenerative", "disease", "clinically", "by", "motor", "and", "C0525041#ent", "<e2>"], "h": {"id": "C0038868", "name": "C0038868#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0525041", "name": "C0525041#ent", "pos": [12, 13]}}
{"token": ["Although", "C1540041#ent", "<e1>", "interacted", "with", "both", "C1823469#ent", "<e2>", "and", "p53", ",", "several", "attempts", "to", "demonstrate", "an", "association", "between", "C1823469#ent", "<e2>", "and", "p53", "were", "unsuccessful", "."], "h": {"id": "C1540041", "name": "C1540041#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823469", "name": "C1823469#ent", "pos": [6, 7]}}
{"token": ["Histograms", "based", "on", "electroneurography", "indicate", "existence", "of", "two", "groups", "of", "results", ",", "that", "might", "reflect", "C1997362#ent", "<e1>", "and/or", "myogenic", "origin", "of", "C0003886#ent", "<e2>", "."], "h": {"id": "C1997362", "name": "C1997362#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003886", "name": "C0003886#ent", "pos": [21, 22]}}
{"token": ["Children", "with", "newly", "or", "previously", "diagnosed", "C0009324#ent", "<e1>", "mild-moderate", "disease", "activity", "were", "treated", "with", "C0043443#ent", "<e2>", "at", "a", "dosage", "of", "4", "mg", "daily", "for", "eight", "weeks", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0043443", "name": "C0043443#ent", "pos": [14, 15]}}
{"token": ["In", "the", "focus", "of", "our", "recent", "work", "was", "the", "C1539479#ent", "<e1>", "of", "the", "C0050405#ent", "<e2>", "its", "eventual", "biotransformed", "products", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0050405", "name": "C0050405#ent", "pos": [13, 14]}}
{"token": ["R-3", "is", "the", "only", "compound", "known", "thus", "far", "that", "interferes", "specifically", "with", "the", "kinase", "activity", "C1458146#ent", "<e1>", "not", "with", "other", "kinases", ",", "such", "as", "protein", "kinase", "C", "the", "C0080054#ent", "<e2>"], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [28, 29]}}
{"token": ["Occasional", "concomitant", "symptoms", "included", "muscular", "pains", "C0018681#ent", "<e1>", ",", "thoracic", "pain", "dyspnea", ",", "hemoptysis", ",", "and", "gastrointestinal", "and", "C2828177#ent", "<e2>"], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C2828177", "name": "C2828177#ent", "pos": [18, 19]}}
{"token": ["The", "transcription", "of", "a", "subset", "of", "these", "C1417679#ent", "<e1>", ",", "which", "includes", "Cdc6", ",", "cyclin", "E", "and", "C0108855#ent", "<e2>", ",", "is", "also", "regulated", "during", "the", "cell", "cycle"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0108855", "name": "C0108855#ent", "pos": [17, 18]}}
{"token": ["The", "elfin", "facies", "syndrome", "is", "characterized", "by", "idiopathic", "infantile", "hypercalcemia", "mental", "retardation", "cardiovascular", "anomalies", "usually", "C1414382#ent", "<e1>", "peripheral", "pulmonary", "artery", "stenosis", "a", "peculiar", "C0332606#ent", "<e2>", "oral", "anomalies", "primarily", "enamel", "hypoplasia", "oligodontia", "."], "h": {"id": "C1414382", "name": "C1414382#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0332606", "name": "C0332606#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "ticlopidine", "induces", "a", "C0040015#ent", "<e1>", "normal", "platelets", "without", "affecting", "the", "C0040015#ent", "<e1>", "quantitatively", "."], "h": {"id": "C0040015", "name": "C0040015#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0040015", "name": "C0040015#ent", "pos": [6, 7]}}
{"token": ["The", "enzyme", "is", "of", "the", "C1956039#ent", "<e1>", "since", "neither", "cyclic", "AMP", "the", "heat-", "and", "acid-stable", "inhibitor", "protein", "specific", "for", "C1956039#ent", "<e1>", "influenced", "its", "activity", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1956039", "name": "C1956039#ent", "pos": [5, 6]}}
{"token": ["Further", "studies", "show", "that", "C0093999#ent", "<e1>", "act", "as", "a", "C0033640#ent", "<e2>", "phosphorylate", "histidine", "protein", "kinases", "as", "EnvZ", "and", "CheA", "which", "are", "members", "of", "the", "His-Asp", "phosphorelay", "signal", "transduction", "systems", "E.", "coli"], "h": {"id": "C0093999", "name": "C0093999#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [9, 10]}}
{"token": ["The", "field", "has", "benefited", "greatly", "from", "C0424790#ent", "<e1>", "cell", "biological", "biophysical", "studies", "the", "mechanism", "used", "by", "cell", "penetrating", "C0030956#ent", "<e2>", "to", "enter", "cells", "and", "deliver", "their", "cargo", "."], "h": {"id": "C0424790", "name": "C0424790#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}}
{"token": ["Finally", ",", "immunohistochemical", "confocal", "laser", "scanning", "microscopy", "suggest", "that", "C0175697#ent", "<e1>", "stimulation", "of", "RAW", "macrophages", "induces", "a", "structural", "change", "the", "N-terminal", "transcriptional", "activation", "domain", "C0919490#ent", "<e2>", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [24, 25]}}
{"token": ["EMSA", "using", "a", "PU.1-specific", "oligonucleotide", "demonstrated", "that", "C0175697#ent", "<e1>", "treatment", "increased", "C0919490#ent", "<e2>", "binding", "activity", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [11, 12]}}
{"token": ["In", "several", "models", ",", "C1442762#ent", "<e1>", "expression", "mediates", "upregulation", "of", "the", "C1522575#ent", "<e2>", "VEGF", ")", "that", "can", "directly", "act", "on", "endothelial", "cells", "promote", "vessel", "formation", "."], "h": {"id": "C1442762", "name": "C1442762#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [11, 12]}}
{"token": ["Studies", "in", "C0012383#ent", "<e1>", "suggested", "that", "secreted", "C0914069#ent", "<e2>", "was", "bound", "to", "alveolar", "surfactant"], "h": {"id": "C0012383", "name": "C0012383#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0914069", "name": "C0914069#ent", "pos": [7, 8]}}
{"token": ["C1366571#ent", "<e1>", "was", "elevated", "for", "96", "hr", "in", "peripheral", "blood", "mononuclear", "cells", "incubated", "with", "C0020457#ent", "<e2>"], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020457", "name": "C0020457#ent", "pos": [14, 15]}}
{"token": ["Giant", "cell", "arteritis", "associated", "with", "markedly", "increased", "risk", "of", "C0003486#ent", "<e1>", "formation", "or", "C0003496#ent", "<e2>", "particularly", "in", "the", "thoracic", "aorta"], "h": {"id": "C0003486", "name": "C0003486#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003496", "name": "C0003496#ent", "pos": [13, 14]}}
{"token": ["A", "man", ",", "aged", "22", ",", "had", "opacity", "of", "both", "C0003742#ent", "<e1>", ",", "following", "severe", "C0155088#ent", "<e2>", "the", "age", "of", "18", "."], "h": {"id": "C0003742", "name": "C0003742#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0155088", "name": "C0155088#ent", "pos": [15, 16]}}
{"token": ["The", "spectrophotometric", "studies", "indicate", "that", "reduction", "of", "the", "C1256751#ent", "<e1>", "according", "to", "the", "analogue", "of", "C1096793#ent", "<e2>", "used", ",", "and", "in", "no", "cases", "is", "it", "complete", "."], "h": {"id": "C1256751", "name": "C1256751#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1096793", "name": "C1096793#ent", "pos": [15, 16]}}
{"token": ["Freely", "fed", "rats", "and", "hypergastrinemic", "rats", "(", "treated", "with", "gastrin", "or", "the", "C0358591#ent", "<e1>", "omeprazole", ")", "had", "higher", "oxyntic", "mucosal", "C1415505#ent", "<e2>", "activity", "and", "C1415505#ent", "<e2>", "mRNA", "level", "than", "fasted", "or", "untreated", "rats", "."], "h": {"id": "C0358591", "name": "C0358591#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415505", "name": "C1415505#ent", "pos": [20, 21]}}
{"token": ["The", "expression", "of", "C3494976#ent", "<e1>", ",", "phosphorylation", "of", "the", "inhibitor", "of", "kappaBalpha", "(", "C1334877#ent", "<e2>", ")", "and", "mitogen-activated", "protein", "kinases", "MAPKs", ")", "was", "determined", "by", "Western", "immunoblotting"], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334877", "name": "C1334877#ent", "pos": [13, 14]}}
{"token": ["Transcriptional", "activation", "of", "the", "human", "C0919425#ent", "<e1>", "coding", "for", "C0008381#ent", "<e2>", "is", "mediated", "by", "the", "aryl", "hydrocarbon", "receptor", "AhR", ")", "."], "h": {"id": "C0919425", "name": "C0919425#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008381", "name": "C0008381#ent", "pos": [9, 10]}}
{"token": ["We", "further", "demonstrate", "that", "C1418894#ent", "<e1>", "binds", "to", "neurofilament", "light", "subunit", "C2981619#ent", "<e2>", ")", "and", "regulates", "C2981619#ent", "<e2>", "ubiquitination", "."], "h": {"id": "C1418894", "name": "C1418894#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2981619", "name": "C2981619#ent", "pos": [11, 12]}}
{"token": ["Additionally", ",", "we", "show", "that", "mice", "deficient", "in", "C1418894#ent", "<e1>", "have", "increased", "C2981619#ent", "<e2>", "level", "in", "axons", "and", "NF-L-filled", "axonal", "swellings", "in", "cerebellum", ",", "retina", ",", "spinal", "cord", "and", "cerebral", "cortex"], "h": {"id": "C1418894", "name": "C1418894#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2981619", "name": "C2981619#ent", "pos": [12, 13]}}
{"token": ["Ewing's", "sarcoma", "associated", "with", "fusion", "between", "the", "C0808901#ent", "<e1>", "and", "FLI1", "genes", ",", "forming", "an", "C3274607#ent", "<e2>"], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [7, 8]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274607", "name": "C3274607#ent", "pos": [15, 16]}}
{"token": ["Approximately", "90", "%", "of", "Ewing's", "sarcoma/primitive", "neuroectodermal", "tumors", "ES/PNET", ")", "have", "a", "specific", "translocation", ",", "t(11;22)(q24;q12", ")", ",", "which", "results", "in", "fusion", "of", "C0808901#ent", "<e1>", "to", "Fli-1", ",", "and", "production", "of", "an", "C3274607#ent", "<e2>"], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [23, 24]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274607", "name": "C3274607#ent", "pos": [32, 33]}}
{"token": ["Loss", "of", "consciousness", "C0034372#ent", "<e1>", "accompanied", "the", "last", "episode", "of", "C1145670#ent", "<e2>"], "h": {"id": "C0034372", "name": "C0034372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [10, 11]}}
{"token": ["Infected", "cells", "with", "T.", "vaginalis", "were", "shown", "to", "associate", "with", "phosphorylation", "of", "the", "extracellular", "signal-regulated", "(ERK)1/2", "kinase", "p38", ",", "C0380051#ent", "<e1>", "JNK", ")", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e2>", "on", "Western", "blot", "analysis"], "h": {"id": "C0380051", "name": "C0380051#ent", "pos": [19, 20]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [27, 28]}}
{"token": ["However", ",", "it", "was", "possible", "that", "both", "C0068334#ent", "<e1>", "and", "6MNA", "inhibited", "a", "prostanoid-mediated", "stimulatory", "effect", "on", "C0003693#ent", "<e2>", "rather", "than", "effecting", "enzyme", "inhibition", "per", "se", "."], "h": {"id": "C0068334", "name": "C0068334#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [17, 18]}}
{"token": ["C0221406#ent", "<e1>", "of", "superoxide", "anions", "the", "vascular", "wall", "to", "endothelial", "dysfunction", "C0268790#ent", "<e2>"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [11, 12]}}
{"token": ["Natural", "antibodies", "independently", "of", "known", "antigenic", "stimulation", "are", "mostly", "C1706005#ent", "<e1>", ",", "polyreactive", ",", "and", "are", "generally", "encoded", "by", "C0035018#ent", "<e2>", "germline", "configuration"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035018", "name": "C0035018#ent", "pos": [19, 20]}}
{"token": ["Three", "protease-activated", "receptors", "C1414437#ent", "<e1>", ")", "for", "thrombin", "--", "PAR1", ",", "PAR3", ",", "and", "C3540804#ent", "<e2>", "--", "are", "now", "known", "."], "h": {"id": "C1414437", "name": "C1414437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540804", "name": "C3540804#ent", "pos": [14, 15]}}
{"token": ["Until", "more", "information", "is", "available", ",", "patients", "with", "vitiligo", "and", "C0040034#ent", "<e1>", "should", "not", "be", "treated", "with", "C0033858#ent", "<e2>", "and", "exposure", "to", "ultraviolet", "light"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033858", "name": "C0033858#ent", "pos": [17, 18]}}
{"token": ["RNA", "silencing", "C1431526#ent", "<e1>", ",", "but", "not", "IP6K2", ",", "inhibited", "exocytosis", ",", "which", "suggests", "that", "C1431526#ent", "<e1>", "is", "the", "critical", "endogenous", "C0031727#ent", "<e1>", "."], "h": {"id": "C1431526", "name": "C1431526#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["A", "Saccharomyces", "cerevisae", "microarray", "expression", "study", "indicated", "that", "an", "C3715179#ent", "<e1>", ",", "YER044C", ",", "now", "designated", "C1412884#ent", "<e2>", ",", "was", "strongly", "coregulated", "with", "ergosterol", "biosynthesis"], "h": {"id": "C3715179", "name": "C3715179#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412884", "name": "C1412884#ent", "pos": [16, 17]}}
{"token": ["Phosphorylation", "assays", "MAP", "kinases", "expression", "studies", "genes", "encoding", "reactive", "oxygen", "species", "and", "-generating", "enzymes", "indicate", "a", "function", "of", "Rac", "and", "C1705860#ent", "<e1>", "in", "fungal", "C0812281#ent", "<e2>", "homoeostasis", "which", "could", "contribute", "to", "their", "drastic", "impact", "on", "differentiation", "."], "h": {"id": "C1705860", "name": "C1705860#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [24, 25]}}
{"token": ["C1422784#ent", "<e1>", "binds", "to", "a", "single", "canonical", "recognition", "site", "the", "C1705280#ent", "<e2>", "promoter", "to", "activate", "gene", "expression", "and", "in", "turn", ",", "p19(ARF", ")", "synthesis", "causes", "p53-dependent", "cell", "cycle", "arrest", "."], "h": {"id": "C1422784", "name": "C1422784#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [10, 11]}}
{"token": ["TAL1", "encodes", "a", "basic", "C3273649#ent", "<e1>", "is", "phosphorylated", "on", "serine", "residue", "by", "the", "C0752312#ent", "<e2>", "MAP", ")", "kinase", "ERK1"], "h": {"id": "C3273649", "name": "C3273649#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [13, 14]}}
{"token": ["C0108836#ent", "<e1>", "is", "an", "evolutionarily", "conserved", "C0031727#ent", "<e2>", "that", "regulates", "S", "phase", "promoting", "replication", "origin", "."], "h": {"id": "C0108836", "name": "C0108836#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}}
{"token": ["However", ",", "when", "it", "arises", "in", "the", "common", "bile", "duct", "C0006863#ent", "<e1>", ")", "and", "is", "associated", "with", "C0022354#ent", "<e2>", "it", "is", "difficult", "to", "distinguish", "it", "from", "bile", "duct", "cancer"], "h": {"id": "C0006863", "name": "C0006863#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [17, 18]}}
{"token": ["There", "was", "also", "a", "trend", "toward", "higher", "median", "soluble", "P-selectin", ",", "PAI", ",", "and", "mean", "C0078956#ent", "<e1>", "levels", "and", "lower", "C1336938#ent", "<e2>", "levels", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [20, 21]}}
{"token": ["Angina", "pectoris", "by", "increased", "myocardial", "oxygen", "demand", "is", "induced", "by", "infusion", "of", "isoproterenol", ",", "a", "beta", "adrenergic", "C0002763#ent", "<e1>", ",", "and", "is", "suppressed", "by", "C0033497#ent", "<e2>", "but", "not", "by", "phentolamine", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [24, 25]}}
{"token": ["In", "the", "isolated", "and", "perfused", "kidney", "of", "the", "rat", ",", "the", "C0002763#ent", "<e1>", "effect", "of", "dopamine", "on", "renin", "release", "is", "blocked", "by", "C0033497#ent", "<e2>", "and", "not", "by", "haloperidol", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [22, 23]}}
{"token": ["Recurrent", "C0038363#ent", "<e1>", "RAS", ")", "is", "a", "common", "C0026636#ent", "<e2>", "however", ",", "despite", "detailed", "clinical", ",", "immunologic", ",", "hematologic", "and", "microbiologic", "investigation", ",", "the", "etiology", "of", "RAS", "remains", "unknown", "."], "h": {"id": "C0038363", "name": "C0038363#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0026636", "name": "C0026636#ent", "pos": [8, 9]}}
{"token": ["The", "relationship", "of", "these", "variables", "with", "C0221423#ent", "<e1>", "more", "specific", "symptoms", "of", "C0721797#ent", "<e2>", "examined", "."], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0721797", "name": "C0721797#ent", "pos": [12, 13]}}
{"token": ["Buspirone", ",", "a", "new", "C0005064#ent", "<e1>", "anxiolytic", "agent", "was", "compared", "with", "C0008174#ent", "<e2>", "in", "a", "double-blind", ",", "multicenter", "trial", "with", "336", "outpatients", "who", "had", "moderate", "to", "severe", "anxiety", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0008174", "name": "C0008174#ent", "pos": [11, 12]}}
{"token": ["With", "sustained", "levels", "of", "anxiety", ",", "C0005064#ent", "<e1>", "as", "diazepam", "and", "C0008174#ent", "<e2>", "are", "usually", "preferred", ",", "while", "episodic", "anxiety", "normally", "responds", "best", "to", "shorter-acting", "drugs", "such", "as", "oxazepam", "or", "lorazepam", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [6, 7]}, "relation": "structural_class_of", "t": {"id": "C0008174", "name": "C0008174#ent", "pos": [11, 12]}}
{"token": ["However", ",", "the", "activity", "of", "C0038838#ent", "<e1>", "normal", "in", "the", "patients", "with", "C0033893#ent", "<e2>", "while", "the", "activity", "of", "C0038838#ent", "<e1>", "the", "patients", "with", "migraine", "was", "lower", "than", "the", "controls", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033893", "name": "C0033893#ent", "pos": [12, 13]}}
{"token": ["The", "C0003195#ent", "<e1>", "and", "cardioprotective", "effects", "of", "both", "C0068700#ent", "<e2>", "and", "aprikalim", "were", "abolished", "by", "pretreating", "the", "rabbits", "with", "5-hydroxydecanoate", "(", "5", "mg/kg", ",", "i.v", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0068700", "name": "C0068700#ent", "pos": [8, 9]}}
{"token": ["In", "C1416870#ent", "<e1>", ",", "T3", "treatment", "had", "no", "significant", "influence", "on", "the", "C1417537#ent", "<e2>", "isoform", "composition", "in", "the", "males", "irrespective", "of", "the", "age", "of", "the", "animal", "."], "h": {"id": "C1416870", "name": "C1416870#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417537", "name": "C1417537#ent", "pos": [12, 13]}}
{"token": ["GST-alpha2", "and", "GST-Jun", "alpha2", "bound", "His-tagged", "calreticulin", "while", "C1415328#ent", "<e1>", "and", "GST-Fos", "beta1", "proteins", "bound", "C1420760#ent", "<e2>", "."], "h": {"id": "C1415328", "name": "C1415328#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420760", "name": "C1420760#ent", "pos": [15, 16]}}
{"token": ["A", "74-year-old", "woman", "with", "chronic", "auricular", "fibrillation", "C0020538#ent", "<e1>", "hypercholesterolemia", ",", "ischemic", "cardiopathy", "and", "peripheral", "arteriopathy", "with", "C0034150#ent", "<e2>", "the", "lower", "limbs", "Fig.", "1", ")", "and", ",", "to", "a", "lesser", "extent", "on", "the", "anterior", "area", "the", "chest", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034150", "name": "C0034150#ent", "pos": [17, 18]}}
{"token": ["This", "enzyme", "is", "an", "C0021699#ent", "<e1>", "cofractionates", "with", "other", "C3541394#ent", "<e2>", "typically", "found", "in", "the", "plasma", "membrane"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}}
{"token": ["In", "short", ",", "I", "suggest", "that", "in", "smooth", "muscle", "telokin", "plays", "a", "C1332924#ent", "<e1>", "role", "for", "C0949646#ent", "<e2>", "and", "its", "filaments", "."], "h": {"id": "C1332924", "name": "C1332924#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0949646", "name": "C0949646#ent", "pos": [16, 17]}}
{"token": ["We", "speculate", "on", "whether", "periodontitisis", "a", "marker", "for", "an", "immune", "hyperresponse", "abnormal", "flora", "which", "in", "the", "oral", "cavity", "results", "in", "C0031099#ent", "<e1>", "and", "in", "the", "case", "of", "C0085166#ent", "<e2>", "result", "in", "preterm", "birth"], "h": {"id": "C0031099", "name": "C0031099#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0085166", "name": "C0085166#ent", "pos": [27, 28]}}
{"token": ["The", "C0031727#ent", "<e1>", "appears", "to", "be", "distinct", "from", "protein", "kinase", "C", "cAMP-dependent", "protein", "kinase", "and", "two", "C1452441#ent", "<e2>", "PAK", "II", "H4P", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1452441", "name": "C1452441#ent", "pos": [16, 17]}}
{"token": ["Normal", "endometrial", "C0623362#ent", "<e1>", "regulation", "in", "response", "to", "either", "C2936882#ent", "<e2>", "or", "progesterone", "requires", "additional", ",", "cell-specific", "interactions", "mediated", "by", "various", "growth", "factors", "cytokines", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [9, 10]}}
{"token": ["This", "was", "inhibited", "by", "C0623362#ent", "<e1>", "MMP", ")", "inhibitor", ",", "while", "cysteine", "proteinase", "inhibitor", "C2936882#ent", "<e2>", "had", "no", "inhibitory", "effect"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [14, 15]}}
{"token": ["Chromatin", "immunoprecipitation", "assays", "a", "requirement", "for", "the", "DRS", "in", "recruiting", "C2984536#ent", "<e1>", "and", "p130", "complexes", "to", "the", "C0812291#ent", "<e2>", "promoter", ",", "indicating", "that", "in", "vivo", "DRS", "governs", "the", "occupancy", "of", "the", "adjacent", "E2F", "site", "transcriptional", "repressors"], "h": {"id": "C2984536", "name": "C2984536#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812291", "name": "C0812291#ent", "pos": [17, 18]}}
{"token": ["Because", "heat", "shock", "the", "expression", "of", "the", "carboxyl", "terminus", "of", "heat", "shock", "cognate", "protein", "70-interacting", "protein", "C1420492#ent", "<e1>", ")", "dramatically", "increased", "eIF4E", "ubiquitination", ",", "C1420492#ent", "<e1>", "may", "be", "at", "least", "one", "C1418270#ent", "<e1>", "for", "eIF4E", "ubiquitination", "."], "h": {"id": "C1420492", "name": "C1420492#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [31, 32]}}
{"token": ["To", "develop", "a", "population", "pharmacokinetic", "model", "C0034283#ent", "<e1>", "(", "PYR", ")", "and", "C0700599#ent", "<e2>", "(", "SDX", ")", "in", "children", "with", "congenital", "toxoplasmosis"], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [6, 7]}, "relation": "part_of", "t": {"id": "C0700599", "name": "C0700599#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "C0034283#ent", "<e1>", "and", "the", "combination", "of", "C0700599#ent", "<e2>", "Fansidar", ")", "upon", "the", "termination", "of", "the", "acute", "attack", "vivax", "malaria", "was", "studied", "in", "Thailand", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [3, 4]}, "relation": "part_of", "t": {"id": "C0700599", "name": "C0700599#ent", "pos": [9, 10]}}
{"token": ["Many", "of", "the", "C0024138#ent", "<e1>", "patients", "studied", "were", "receiving", "C3539185#ent", "<e2>", "."], "h": {"id": "C0024138", "name": "C0024138#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539185", "name": "C3539185#ent", "pos": [9, 10]}}
{"token": ["The", "present", "study", "examined", "the", "sleep-wake", "cycle", "of", "microinjections", "of", "C0724441#ent", "<e1>", ",", "an", "adrenergic", "antagonist", "and", "atropine", ",", "a", "C0242897#ent", "<e2>", "into", "the", "cerebral", "ventricle", "clomipramine-induced", "depressed", "rats", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242897", "name": "C0242897#ent", "pos": [20, 21]}}
{"token": ["Like", "other", "small", "monomeric", "proteins", "C0001497#ent", "<e1>", "rapidly", "to", "the", "native", "active", "state", "dilution", "of", "C0120447#ent", "<e2>"], "h": {"id": "C0001497", "name": "C0001497#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0120447", "name": "C0120447#ent", "pos": [15, 16]}}
{"token": ["After", "denaturation", "in", "6", "M", "guanidinium", "hydrochloride", "mutant", "and", "parent", "C0001497#ent", "<e1>", "rapidly", "to", "the", "native", ",", "active", "state", "dilution", "of", "C0120447#ent", "<e2>"], "h": {"id": "C0001497", "name": "C0001497#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0120447", "name": "C0120447#ent", "pos": [21, 22]}}
{"token": ["C0948201#ent", "<e1>", "antenatal", "glomerulopathies", "(", "FMAIG", ")", "is", "a", "recently", "described", "C0021053#ent", "<e2>", "which", "results", "from", "maternal", "antibodies", "cross", "the", "placenta", ",", "bind", "to", "fetal", "glomerular", "podocytes", ",", "and", "mediate", "renal", "disease"], "h": {"id": "C0948201", "name": "C0948201#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "endocytosis", "is", "subject", "to", "modulation", "by", "different", "signaling", "systems", "such", "as", "C0033640#ent", "<e1>", "PKA", ")", ",", "protein", "kinase", "C", "PKC", ")", ",", "C0044602#ent", "<e2>", "PI3-K", ")", "and", "transforming", "growth", "factor", "beta", "TGF-beta", ")", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [24, 25]}}
{"token": ["Thus", ",", "the", "block", "of", "apoptosis", "imposed", "by", "C1840636#ent", "<e1>", "in", "pro-B", "lymphocytes", "critically", "on", "the", "transactivating", "regions", "C1336596#ent", "<e2>", "."], "h": {"id": "C1840636", "name": "C1840636#ent", "pos": [8, 9]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [18, 19]}}
{"token": ["This", "DHA-induced", "amelioration", "of", "serum", "lipid", "changes", "in", "SPSHR", "might", "be", "associated", "with", "mechanisms", "involving", "the", "C0003364#ent", "<e1>", "induced", "by", "C2348308#ent", "<e2>", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2348308", "name": "C2348308#ent", "pos": [20, 21]}}
{"token": ["LLC-PK1", "cells", "cultured", "for", "6", "days", "with", "5.5", "-", "27.8", "mM", "C0017718#ent", "<e1>", "were", "challenged", "by", "fluorescein", "isothiocyanate", "C0304925#ent", "<e2>", "HA", ")", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0304925", "name": "C0304925#ent", "pos": [18, 19]}}
{"token": ["Collectively", ",", "these", "data", "are", "consistent", "with", "supposition", "that", "the", "H.", "diminuta", "mitochondrial", "NADH-->NAD", "transhydrogenation", "reaction", "is", "catalyzed", "by", "C0023783#ent", "<e1>", "possibly", "by", "C0171406#ent", "<e2>", "than", "by", "an", "independent", "transhydrogenase", "system"], "h": {"id": "C0023783", "name": "C0023783#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [23, 24]}}
{"token": ["C0023783#ent", "<e1>", "a", "component", "of", "the", "alpha-ketoglutarate", "dehydrogenase", "complex", "two", "other", "C0171406#ent", "<e2>", "catalyzes", "the", "transfer", "of", "reducing", "equivalents", "from", "the", "bound", "dihydrolipoate", "of", "the", "neighboring", "dihydrolipoamide", "acyltransferase", "subunit", "NAD(+", ")", "."], "h": {"id": "C0023783", "name": "C0023783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [11, 12]}}
{"token": ["C0005940#ent", "<e1>", "classified", "as", "early", "hyperparathyroidism", ",", "C0016063#ent", "<e2>", "mixed", "disease", "osteomalacia", ",", "adynamic", "bone", "disease", "other", "bone", "condition", "osteoid", "volume", ",", "relative", "osteoblastic", "activity", "ROBA%", ")", ",", "and", "the", "presence", "of", "fibrosis", ",", "as", "criteria", "."], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016063", "name": "C0016063#ent", "pos": [7, 8]}}
{"token": ["C0005940#ent", "<e1>", "found", "in", "27", "%", ",", "C0016063#ent", "<e2>", "mixed", "bone", "disease", "27", "%", ",", "and", "mild", "bone", "disorder", "12", "%", "of", "patients", "."], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016063", "name": "C0016063#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "C1420740#ent", "<e1>", "is", "a", "novel", "type", "of", "C0751651#ent", "<e2>"], "h": {"id": "C1420740", "name": "C1420740#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751651", "name": "C0751651#ent", "pos": [9, 10]}}
{"token": ["The", "authors", "deal", "with", "antibacterial", "effectivity", "of", "blood", "serum", "urine", "in", "simultaneous", "administration", "of", "C0282563#ent", "<e1>", "and", "tetracyclines", "under", "in", "vivo", "conditions", ",", "using", "C1318973#ent", "<e2>"], "h": {"id": "C0282563", "name": "C0282563#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1318973", "name": "C1318973#ent", "pos": [24, 25]}}
{"token": ["Within", "the", "family", "group", "acquaintance", "with", "C0043528#ent", "<e1>", "their", "prevention", "was", "an", "inconsistent", "finding", ",", "with", "C0040553#ent", "<e2>", "and", "toxoplasmosis", "being", "the", "diseases", "associated", "with", "greatest", "degree", "of", "ignorance", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0040553", "name": "C0040553#ent", "pos": [16, 17]}}
{"token": ["C0857122#ent", "<e1>", "hypochloremic", "dehydration", "with", "C0220983#ent", "<e2>", "a", "rare", "but", "typical", "presentation", "of", "CF", "in", "infants", "."], "h": {"id": "C0857122", "name": "C0857122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0220983", "name": "C0220983#ent", "pos": [5, 6]}}
{"token": ["This", "assay", "was", "able", "to", "measure", "steady-state", "C0024027#ent", "<e1>", "concentration", "(", "C0265338#ent", "<e2>", ")", "at", "the", "initial", "dose", "level", "in", "a", "phase", "I", "trial", "C0024027#ent", "<e1>", "as", "a", "modulator", "of", "apoptosis", "."], "h": {"id": "C0265338", "name": "C0265338#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024027", "name": "C0024027#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "C0729078#ent", "<e1>", "may", "be", "effective", "in", "controlling", "C0020437#ent", "<e2>", "to", "excess", "bone", "resorption"], "h": {"id": "C0729078", "name": "C0729078#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [11, 12]}}
{"token": ["PKD", "is", "the", "founding", "member", "of", "a", "novel", "C0031727#ent", "<e1>", "also", "includes", "C1538717#ent", "<e2>", "and", "PKD3", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538717", "name": "C1538717#ent", "pos": [12, 13]}}
{"token": ["EWS", "and", "related", "C3272488#ent", "<e1>", "and", "TLS/FUS", "genes", "are", "fused", "with", "different", "C1417679#ent", "<e2>", "encoding", "transcription", "factors", "various", "human", "cancers", "."], "h": {"id": "C3272488", "name": "C3272488#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["The", "property", "of", "K+", "selectivity", "is", "related", "to", "the", "presence", "of", "two", "C3539947#ent", "<e1>", "are", "absent", "from", "the", "C1418887#ent", "<e2>", "the", "cyclic", "nucleotide-gated", "channels"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [18, 19]}}
{"token": ["It", "is", "shown", "here", "that", "the", "first", "34", "C3539947#ent", "<e1>", "the", "N-terminal", "region", "of", "either", "human", "or", "murine", "C1418887#ent", "<e2>", "are", "soluble", "in", "aqueous", "medium", "and", "spontaneously", "insert", "into", "membranes", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [18, 19]}}
{"token": ["Group", "1", "n", "=", "24", ")", "had", "severe", "C3640068#ent", "<e1>", "group", "2", "n", "=", "10", ")", "had", "mild", ",", "C3640068#ent", "<e1>", "and", "group", "3", "n", "=", "6", ")", "had", "unilateral", "C0338502#ent", "<e1>"], "h": {"id": "C3640068", "name": "C3640068#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0338502", "name": "C0338502#ent", "pos": [30, 31]}}
{"token": ["PDGF", "stimulates", "Cdk5", "activity", "in", "a", "time-dependent", "manner", ",", "whereas", "suppression", "of", "Cdk5", "by", "the", "specific", "inhibitor", "C0536217#ent", "<e1>", "or", "by", "the", "retrovirus", "encoding", "short-hairpin", "RNA", "Cdk5", "impairs", "PDGF-dependent", "C3273483#ent", "<e2>", "migration", "."], "h": {"id": "C0536217", "name": "C0536217#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3273483", "name": "C3273483#ent", "pos": [29, 30]}}
{"token": ["The", "addition", "of", "very", "small", "doses", "of", "C0062637#ent", "<e1>", "optimal", "doses", "of", "C0699178#ent", "<e2>", "improved", "the", "effect", "of", "the", "C0699178#ent", "<e2>", "in", "three", "patients", "."], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0699178", "name": "C0699178#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "the", "effect", "induced", "by", "carbachol", "is", "due", "to", "activation", "of", "muscarinic", "receptors", "it", "is", "totally", "blocked", "by", "local", "C0596005#ent", "<e1>", "is", "reproduced", "by", "dioxolane", ",", "an", "exclusive", "C0242947#ent", "<e2>"], "h": {"id": "C0596005", "name": "C0596005#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0242947", "name": "C0242947#ent", "pos": [30, 31]}}
{"token": ["We", "suggest", "that", "colchicine", "may", "be", "a", "helpful", "and", "safe", "C1254351#ent", "<e1>", "for", "patients", "with", "C0079293#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079293", "name": "C0079293#ent", "pos": [15, 16]}}
{"token": ["Ten", "of", "the", "28", "have", "hemophilia", "A", "six", "have", "C0008533#ent", "<e1>", "and", "12", "have", "severe", "C0042974#ent", "<e2>"], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042974", "name": "C0042974#ent", "pos": [15, 16]}}
{"token": ["Phenotypic", "prevention", "describes", "medical", "efforts", "forestall", "the", "clinical", "manifestation", "a", "C0037277#ent", "<e1>", "an", "at-risk", "patient", ",", "like", "newborn", "screening", "and", "dietary", "prophylaxis", "C0751434#ent", "<e2>", "."], "h": {"id": "C0037277", "name": "C0037277#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751434", "name": "C0751434#ent", "pos": [22, 23]}}
{"token": ["C0546849#ent", "<e1>", "or", "furosemide", "reduced", "BP", "in", "CD", "C3273437#ent", "<e2>", "KO", "mice", "on", "a", "normal", "or", "high-Na", "diet", "and", "prevented", "excessive", "Na", "retention", "in", "salt-loaded", "CD", "C3273437#ent", "<e2>", "KO", "mice", "."], "h": {"id": "C0546849", "name": "C0546849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [8, 9]}}
{"token": ["Other", "treatments", "that", "caused", "a", "significant", "elevation", "of", "hypothalamic", "cyclic", "AMP", ":", "(", "a", ")", "C0041260#ent", "<e1>", "plus", "the", "C3536878#ent", "<e2>", "tranylcypromine", ",", "and", "(", "b", ")", "the", "serotonin", "agonist", "1-(m-trifluromethylphenyl)-1-piperazine", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3536878", "name": "C3536878#ent", "pos": [19, 20]}}
{"token": ["The", "combination", "of", "C0041260#ent", "<e1>", "and", "a", "C3536878#ent", "<e2>", "MAOI", ")", "has", "been", "reported", "to", "be", "an", "effective", "antidepressant", "regimen", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536878", "name": "C3536878#ent", "pos": [7, 8]}}
{"token": ["In", "the", "rats", ",", "pretreated", "with", "a", "5-hydroxytryptamine", "precursor", "C0041260#ent", "<e1>", ",", "and", "with", "a", "C3536878#ent", "<e2>", "nialamide", ",", "a", "large", "number", "of", "5-hydroxytryptamine-immunoreactive", "nerve", "fiber", "terminals", "were", "detected", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536878", "name": "C3536878#ent", "pos": [15, 16]}}
{"token": ["Tight", "linkage", "these", "candidate", "C0017337#ent", "<e1>", "was", "excluded", "with", "LOD", "scores", "for", "C1413580#ent", "<e2>", "of", "-2.45", "at", "theta", "=", "0.05", "and", "for", "CRTL1", "of", "-7.28", "at", "theta", "=", "0.001", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413580", "name": "C1413580#ent", "pos": [12, 13]}}
{"token": ["Not", "all", "of", "the", "6", "classical", "lesions", "(", "hemangioblastoma", "of", "the", "CNS", ",", "retinal", "angiomatosis", "C0030283#ent", "<e1>", "renal", "cysts", "carcinoma", ",", "pheochromocytoma", "and", "epididymal", "cystadenoma", "are", "present", "in", "C0694897#ent", "<e2>", "families", "."], "h": {"id": "C0030283", "name": "C0030283#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0694897", "name": "C0694897#ent", "pos": [28, 29]}}
{"token": ["Fifty", "patients", "with", "endoscopically", "verified", "C0013295#ent", "<e1>", "treated", "with", "100", "mg", "of", "C0700466#ent", "<e2>", "corresponding", "to", "89.4", "mg", "of", "ranitidine", "base", ")", "or", "identical", "placebo", "tablets", "twice", "daily", "under", "double-blind", "conditions"], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0700466", "name": "C0700466#ent", "pos": [12, 13]}}
{"token": ["We", "studied", "also", "the", "cerebellar", "cortex", "4", "cases", "of", "C2931903#ent", "<e1>", "OPCA", ")", ",", "a", "C0039082#ent", "<e2>", "in", "which", "Purkinje", "and", "granule", "cells", "degenerate", "."], "h": {"id": "C2931903", "name": "C2931903#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [15, 16]}}
{"token": ["Altogether", ",", "these", "results", "indicate", "that", "PDGF", "activates", "C1705632#ent", "<e1>", "through", "a", "pathway", "that", "involves", "both", "C0044602#ent", "<e2>", "PLC-gamma", "and", "subsequent", "activation", "of", "protein", "kinase"], "h": {"id": "C1705632", "name": "C1705632#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [16, 17]}}
{"token": ["The", "inhibitory", "action", "of", "insulin", "on", "SEK1", "or", "C1705632#ent", "<e1>", "activation", "was", "prevented", "by", "the", "C0044602#ent", "<e2>", "LY294002", "."], "h": {"id": "C1705632", "name": "C1705632#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [15, 16]}}
{"token": ["In", "glomerular", "mesangial", "cells", "C3273436#ent", "<e1>", "stimulated", "a", "biphasic", "increase", "in", "C1705341#ent", "<e2>", "activity", "in", "anti-phosphotyrosine", "immunoprecipitates", "that", "temporally", "correlated", "with", "increased", "tyrosine", "phosphorylation", "cellular", "proteins"], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [11, 12]}}
{"token": ["Alterations", "at", "microsatellite", "repeat", "motifs", "in", "the", "coding", "regions", "four", "C0596240#ent", "<e1>", "TGF", "beta", "RII", ",", "IGFIIR", ",", "BAX", ",", "and", "C1414227#ent", "<e2>", ")", "were", "not", "observed", "."], "h": {"id": "C0596240", "name": "C0596240#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414227", "name": "C1414227#ent", "pos": [21, 22]}}
{"token": ["The", "VP1", "protein", "23", "kDa", ")", "of", "the", "foot-and-mouth", "disease", "virus", "been", "produced", "in", "MC1061", "and", "BL21", "E.", "coli", "strains", "as", "C0005220#ent", "<e1>", "joined", "to", "either", "the", "C0002523#ent", "<e2>", "and/or", "the", "carboxy", "termini", "the", "bacterial", "enzyme"], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0002523", "name": "C0002523#ent", "pos": [27, 28]}}
{"token": ["Inhalation", "of", "C1415831#ent", "<e1>", "nitrite", "produced", "marked", "C0003364#ent", "<e2>", "with", "the", "dose-response", "curves", "being", "shifted", "to", "the", "right", "by", "i.c.v", "."], "h": {"id": "C1415831", "name": "C1415831#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [7, 8]}}
{"token": ["Inhalation", "of", "C1415831#ent", "<e1>", "nitrite", "evoked", "larger", "C0003364#ent", "<e2>", "did", "not", "affect", "unit", "activity", "nor", "did", "inhalation", "of", "CO(2", ")", "(", "hypercapnia", ")", "or", "N(2)O", "(hypoxia).7", "."], "h": {"id": "C1415831", "name": "C1415831#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [7, 8]}}
{"token": ["Early", "hepatorenal", "grafting", "uremia", "secondary", "to", "hyperoxaluria", "type", "1", "would", "avoid", "the", "deleterious", "clinical", "consequences", "of", "C0268165#ent", "<e1>", "shorten", "the", "duration", "of", "C0020500#ent", "<e2>", "which", "may", "compromise", "the", "course", "of", "kidney", "graft"], "h": {"id": "C0268165", "name": "C0268165#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [22, 23]}}
{"token": ["Similar", "protective", "effects", "observed", "by", "perfusing", "the", "heart", "with", "reduced", "calcium", "but", "not", "by", "nifedipine", ";", "a", "C0006684#ent", "<e1>", "indomethacin", ";", "a", "prostaglandin", "synthesis", "inhibitor", "or", "nordihydroguarietic", "acid", "a", "C0085385#ent", "<e2>"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085385", "name": "C0085385#ent", "pos": [29, 30]}}
{"token": ["At", "1", "microM", ",", "C0075193#ent", "<e1>", "was", "a", "potent", "inhibitor", "of", "superoxide", "generation", "stimulated", "by", "both", "C1333574#ent", "<e2>", "and", "PAF", "but", "was", "without", "effect", "on", "that", "stimulated", "by", "OPZ", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "expression", "of", "C1423062#ent", "<e1>", "deacetylase", "and", "the", "addition", "of", "a", "C1423062#ent", "<e1>", "C0243192#ent", "<e1>", ",", "resveratrol", ",", "reduced", "Q79C", "toxicity", "."], "h": {"id": "C1423062", "name": "C1423062#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [14, 15]}}
{"token": ["In", "Saccharomyces", "cerevisiae", "Cu", ",", "C0669516#ent", "<e1>", "coregulated", "with", "copper-thionein", "by", "copper", "via", "the", "C1420631#ent", "<e2>"], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420631", "name": "C1420631#ent", "pos": [14, 15]}}
{"token": ["The", "human", "gene", "this", "protein", "has", "been", "termed", "DFF40", "(", "DNA", "fragmentation", "factor", "40-kd", "subunit", ")", "or", "caspase-activated", "nuclease", "CPAN", ")", ",", "whereas", "the", "C1334043#ent", "<e1>", "been", "named", "C0669174#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0669174", "name": "C0669174#ent", "pos": [28, 29]}}
{"token": ["Lipopolysaccharide", "also", "stimulated", "the", "secretion", "of", "C1366524#ent", "<e1>", "by", "ESC", ",", "but", "not", "by", "C1414371#ent", "<e2>", "."], "h": {"id": "C1366524", "name": "C1366524#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414371", "name": "C1414371#ent", "pos": [14, 15]}}
{"token": ["Previous", "studies", "from", "our", "laboratory", "and", "others", "demonstrated", "a", "relative", "insensitivity", "of", "the", "renal", "vasculature", "the", "C4255305#ent", "<e1>", "influences", "of", "C1366535#ent", "<e2>", "AVP", ")", "."], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [20, 21]}}
{"token": ["The", "most", "potent", "C4255305#ent", "<e1>", "(", "the", "lowest", "EC50", "concentration", ")", "was", "C1366535#ent", "<e2>", "AVP", ")", "followed", "in", "order", "by", "endothelin", ",", "oxytocin", ",", "prostaglandin", "(PG)F2", "alpha", "noradrenalin", "and", "dopamine", "."], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [12, 13]}}
{"token": ["Partial", "defects", "of", "COX", "have", "been", "shown", "in", "muscle", "of", "patients", "with", "progressive", "external", "C0029089#ent", "<e1>", ",", "either", "alone", "(", "C0270951#ent", "<e2>", "or", "as", "part", "of", "Kearns-Sayre", "syndrome"], "h": {"id": "C0029089", "name": "C0029089#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0270951", "name": "C0270951#ent", "pos": [20, 21]}}
{"token": ["Until", "recently", ",", "the", "only", "known", "genetic", "defect", "to", "C4284230#ent", "<e1>", "was", "the", "C2986687#ent", "<e2>", "ICOS", ")", "deficiency", ",", "which", "accounts", "for", "less", "than", "1", "%", "of", "the", "patients", "."], "h": {"id": "C4284230", "name": "C4284230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986687", "name": "C2986687#ent", "pos": [13, 14]}}
{"token": ["The", "specific", "C1413309#ent", "<e1>", "of", "antibodies", "directed", "against", "mammalian", "liver", "type", "I", "11", "beta-hydroxysteroid", "dehydrogenase", "11", "C3489584#ent", "<e2>", "with", "the", "isolated", "3", "alpha-HSDs", "suggests", "the", "existence", "of", "a", "functionally", "and", "structurally", "related", "subgroup", "within", "the", "SDR", "superfamily"], "h": {"id": "C1413309", "name": "C1413309#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3489584", "name": "C3489584#ent", "pos": [16, 17]}}
{"token": ["Origin", "recognition", "complex", "ORC", ")", "is", "a", "six", "C1335531#ent", "<e1>", "functions", "as", "the", "C1425179#ent", "<e2>", "is", "required", "for", "silencing", "the", "HML", "and", "HMR", "loci", "in", "the", "yeast", "Saccharomyces", "cerevisiae"], "h": {"id": "C1335531", "name": "C1335531#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425179", "name": "C1425179#ent", "pos": [13, 14]}}
{"token": ["Histamine", "H2-receptor", "antagonists", "metiamide", "and", "C0008783#ent", "<e1>", "were", "used", "in", "the", "treatment", "of", "severe", "C0030925#ent", "<e2>", "Zollinger-Ellison", "syndrome"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030925", "name": "C0030925#ent", "pos": [14, 15]}}
{"token": ["C0008783#ent", "<e1>", ",", "a", "histamine", "H2-receptor", "antagonist", "widely", "used", "to", "treat", "C0030925#ent", "<e2>", "is", "known", "to", "cause", "gynecomastia", "and", "sexual", "dysfunction", "some", "men", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030925", "name": "C0030925#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "both", "the", "C0033640#ent", "<e1>", "pp60", "are", "encoded", "in", "C3853644#ent", "<e2>", ",", "and", "that", "the", "enzymatic", "activity", "be", "an", "intrinsic", "property", "of", "pp60", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [11, 12]}}
{"token": ["The", "plasma", "renin", "activity", "was", "markedly", "decreased", "after", "injection", "of", "C0036193#ent", "<e1>", "and", "captopril", "into", "the", "cerebral", "ventricles", "two-kidney", ",", "C0018036#ent", "<e2>", "rats", "."], "h": {"id": "C0036193", "name": "C0036193#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018036", "name": "C0018036#ent", "pos": [20, 21]}}
{"token": ["Abnormalities", "of", "small", "bowel", "transit", "be", "demonstrated", "in", "patients", "with", "the", "C0022104#ent", "<e1>", "and", "patients", "with", "chronic", "idiopathic", "intestinal", "pseudo-obstruction", "to", "either", "a", "visceral", "myopathy", "C0021847#ent", "<e2>", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [25, 26]}}
{"token": ["We", "report", "on", "a", "favourable", "case", "of", "C0220710#ent", "<e1>", "homozygous", "985A", ">", "G", ")", "that", "presented", "as", "C0023380#ent", "<e2>", ",", "poor", "feeding", "pulmonary", "haemorrhage", "cardiac", "arrest", "hypoglycaemia", "."], "h": {"id": "C0220710", "name": "C0220710#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [17, 18]}}
{"token": ["The", "rate", "of", "hypoglycemia", "in", "C1704662#ent", "<e1>", "infants", "was", "significantly", "higher", "than", "the", "rate", "in", "the", "C0162311#ent", "<e2>", "infants", "(", "p", "=", "0.0000", ")", "."], "h": {"id": "C1704662", "name": "C1704662#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162311", "name": "C0162311#ent", "pos": [16, 17]}}
{"token": ["Residues", "of", "Asp", ",", "Glu", ",", "C2000261#ent", "<e1>", ",", "His", ",", "and", "C1822773#ent", "<e2>", "act", "as", "catalysts", "of", "denitrosation", "(", "internal", "denitrosilase", ")", "."], "h": {"id": "C2000261", "name": "C2000261#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1822773", "name": "C1822773#ent", "pos": [12, 13]}}
{"token": ["The", "mitral", "valve", "replacement", "a", "common", "and", "live-saving", "procedure", ",", "many", "complications", "may", "occur", "as", "therefore", ":", "C0014118#ent", "<e1>", ",", "thromboembolism", ",", "and", "bleedings", "because", "the", "lifelong", "C0010207#ent", "<e2>", "medication", "."], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010207", "name": "C0010207#ent", "pos": [27, 28]}}
{"token": ["However", ",", "first-line", "drugs", "for", "nondiabetic", "patients", "(", "nicotinic", "acid", "C2917337#ent", "<e1>", "may", "be", "less", "desirable", "in", "C3273872#ent", "<e2>", "patients", "than", "hydroxymethylglutaryl", "coenzyme", "A", "HMG", "CoA)", "reductase", "inhibitors", "even", "fibric", "acids"], "h": {"id": "C2917337", "name": "C2917337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [17, 18]}}
{"token": ["Sarcoma", "virus-positive", ",", "leukemia", "virus-negative", "(", "S", "+", "L", "-", ")", "mouse", "cells", "by", "defective", "but", "rescuable", "murine", "sarcoma", "virus", "C1704880#ent", "<e1>", ")", "release", "noninfectious", "type", "C", "virions", "with", "a", "quantitative", "deficiency", "C0035681#ent", "<e2>", "RDDP", ")", "."], "h": {"id": "C1704880", "name": "C1704880#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [32, 33]}}
{"token": ["Incubation", "of", "C1333690#ent", "<e1>", "septic", "animals", "ibuprofen", "enhanced", "(", "p", "less", "than", "0.05", ")", "C1522428#ent", "<e2>", "and", "TNF", "synthesis", ",", "while", "IL-6", "production", "was", "reduced", "(", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [14, 15]}}
{"token": ["Lightly", "restrained", "albino", "rats", "were", "administered", "dipropylacetic", "acid", "C0041038#ent", "<e1>", ",", "diphenylhydantoin", ",", "saline", ",", "and", "a", "C0030903#ent", "<e2>", "challenge", "."], "h": {"id": "C0041038", "name": "C0041038#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030903", "name": "C0030903#ent", "pos": [17, 18]}}
{"token": ["Six", "spontaneously", "occurring", "coaggregation-defective", "(", "Cog-", ")", "mutants", "of", "wild-type", "strain", "S.", "gordonii", "C3815532#ent", "<e1>", "unable", "to", "coaggregate", "with", "C2987364#ent", "<e2>", "streptococcal", "partners", "were", "characterized", "."], "h": {"id": "C3815532", "name": "C3815532#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [19, 20]}}
{"token": ["The", "activity", "of", "C1505790#ent", "<e1>", "the", "enzyme", "responsible", "for", "C0001109#ent", "<e2>", "exposure", ",", "is", "normal", "or", "elevated", "in", "cultured", "fibroblasts", "from", "both", "I-cell", "disease", "pseudo-Hurler", "polydystrophy", "patients", "."], "h": {"id": "C1505790", "name": "C1505790#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001109", "name": "C0001109#ent", "pos": [9, 10]}}
{"token": ["C1417458#ent", "<e1>", "MSR", ")", "catalyzes", "the", "C3538941#ent", "<e2>", "of", "methionine", "synthase"], "h": {"id": "C1417458", "name": "C1417458#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538941", "name": "C3538941#ent", "pos": [6, 7]}}
{"token": ["To", "evaluate", "the", "effect", "of", "C0041948#ent", "<e1>", "alone", "and", "C0041948#ent", "<e1>", "plus", "C0025297#ent", "<e1>", "on", "the", "neurotoxity", "of", "BPC", "in", "rabbits", ",", "cephaloridine", "was", "used", "to", "induce", "C0041948#ent", "<e1>", "."], "h": {"id": "C0041948", "name": "C0041948#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [12, 13]}}
{"token": ["Here", ",", "we", "investigated", "the", "role", "of", "the", "NF-kappaB", "target", "C3814411#ent", "<e1>", "in", "the", "regulation", "of", "hepatocyte", "C1539479#ent", "<e2>", "during", "liver", "regeneration", "partial", "hepatectomy", "."], "h": {"id": "C3814411", "name": "C3814411#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [17, 18]}}
{"token": ["The", "mammalian", "SIN3", "complex", "consists", "of", "histone", "deacetylases", "C1334032#ent", "<e1>", ",", "HDAC2", ")", ",", "several", "known", "C0086376#ent", "<e2>", "(", "SAP30", ",", "N-CoR", ")", "and", "as", "yet", "unidentified", "C0086376#ent", "<e2>", "."], "h": {"id": "C1334032", "name": "C1334032#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}}
{"token": ["Co-localization", "and", "association", "of", "Mi-2", ",", "RFP", ",", "and", "C1334032#ent", "<e1>", "that", "these", "C0086376#ent", "<e2>", "cooperate", "in", "transcriptional", "repression"], "h": {"id": "C1334032", "name": "C1334032#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["While", "Decapentaplegic", "(", "C1414174#ent", "<e1>", ")", "acts", "downstream", "of", "C0034678#ent", "<e2>", "to", "maintain", "vein", "cell", "in", "the", "pupal", "wing", ",", "our", "results", "indicate", "that", "Ras", "controls", "Shg", "localization", "a", "Dpp-independent", "mechanism", "."], "h": {"id": "C1414174", "name": "C1414174#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [9, 10]}}
{"token": ["C0162569#ent", "<e1>", "inherited", "as", "an", "autosomal", "recessive", "trait", "whereas", "C0268323#ent", "<e2>", "dominant", "."], "h": {"id": "C0162569", "name": "C0162569#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268323", "name": "C0268323#ent", "pos": [9, 10]}}
{"token": ["This", "is", "the", "third", "case", "of", "an", "C0162569#ent", "<e1>", "mutation", "in", "an", "individual", "diagnosed", "with", "C0268323#ent", "<e2>"], "h": {"id": "C0162569", "name": "C0162569#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268323", "name": "C0268323#ent", "pos": [15, 16]}}
{"token": ["In", "immunofluorescence", "the", "amount", "of", "immunoglobulin", "and", "C3", "deposits", "the", "glomerular", "capillary", "wall", "to", "be", "less", "in", "C0019142#ent", "<e1>", "treated", "mice", "compared", "to", "C0033770#ent", "<e2>", "treated", "controls", "(", "P", "=", "0.07", ")", "."], "h": {"id": "C0019142", "name": "C0019142#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0033770", "name": "C0033770#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "present", "another", "C1332660#ent", "<e1>", "case", "with", "resolution", "of", "C0020305#ent", "<e2>", "prenatal", "betamethasone", "therapy", "but", "which", "was", "followed", "by", "later", "intrauterine", "death"], "h": {"id": "C1332660", "name": "C1332660#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [10, 11]}}
{"token": ["Conversely", ",", "four", "C1332660#ent", "<e1>", "cases", "with", "in-utero", "resolution", "of", "C0020305#ent", "<e2>", "prenatal", "betamethasone", "therapy", "with", "good", "clinical", "outcome", "been", "reported", "in", "the", "literature", "."], "h": {"id": "C1332660", "name": "C1332660#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [10, 11]}}
{"token": ["Oxidative", "stress", "seen", "in", "both", "familial", "and", "sporadic", "forms", "C1704945#ent", "<e1>", ",", "may", "be", "only", "one", "post-translational", "mechanism", "to", "affect", "specific", "C0086376#ent", "<e2>", "essential", "for", "the", "health", "and", "stability", "of", "motor", "neurons"], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}}
{"token": ["The", "results", "show", "unequivocally", "that", "C1704945#ent", "<e1>", "and", "bursicon", "are", "distinctly", "different", "C0086376#ent", "<e2>", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["Our", "results", "point", "to", "the", "possibility", "of", "an", "immune", "reaction", "C1704945#ent", "<e1>", "patients", "against", "ephemeral", "C0086376#ent", "<e2>", "of", "muscle", "that", "are", "present", "in", "large", "quantities", "at", "early", "stages", "muscle", "differentiation", "innervation", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["Two", "other", "C0030940#ent", "<e1>", "(", "mouse", "submaxillaris", "protease", "and", "C0126502#ent", "<e2>", "with", "specificities", "similar", "to", "trypsin", "generated", "a", "distribution", "of", "GTF-S", "peptides", "that", "was", "also", "greatly", "enriched", "in", "the", "glucan-binding", "peptide", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0126502", "name": "C0126502#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "the", "DNA", "sequences", "the", "frame-shift", "revertants", "above", "predict", "relative", "isolectric", "point", "differences", "between", "the", "C2987364#ent", "<e1>", "and", "various", "C0035379#ent", "<e2>", "forms", "of", "the", "polypeptide", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [20, 21]}}
{"token": ["The", "attachment", "and", "exchange", "activities", "the", "lysS2", "enzyme", "are", "more", "heat", "labile", "in", "vitro", "the", "C2987364#ent", "<e1>", "enzyme", ",", "as", "is", "the", "attachment", "activity", "a", "partial", "C0035379#ent", "<e2>", "of", "the", "lysS1", "mutant", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [26, 27]}}
{"token": ["Two", "had", "no", "bowel", "activity", "24", "hours", ":", "one", "had", "C0010674#ent", "<e1>", "one", "had", "neonatal", "C0019158#ent", "<e2>", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [15, 16]}}
{"token": ["Although", "quinapril", "did", "not", "restore", "the", "effects", "of", "receptor", "stimulation", "or", "prevent", "the", "increase", "in", "C3811132#ent", "<e1>", "mRNA", ",", "it", "did", "restore", "cardiac", "C1328053#ent", "<e2>", "expression", "."], "h": {"id": "C3811132", "name": "C3811132#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [23, 24]}}
{"token": ["Protein", "expression", "cyclin", "E", "C0108855#ent", "<e1>", ",", "the", "kinase", "activity", "complexed", "cyclin", "E/CDK2", ",", "and", "protein", "expression", "C0525037#ent", "<e2>", ",", "p21", ",", "and", "p27", "were", "all", "unaffected", "by", "oligomycin", "administration", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [17, 18]}}
{"token": ["We", "propose", "that", "an", "elastase-like", "enzyme", ",", "probably", "different", "from", "elastase", "1", "C0598349#ent", "<e1>", "is", "liberated", "from", "the", "C0771711#ent", "<e2>", "into", "blood", "during", "acute", "pancreatitis", "becomes", "combined", "with", "alpha", "2-macroglobulin"], "h": {"id": "C0598349", "name": "C0598349#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [18, 19]}}
{"token": ["However", ",", "we", "have", "not", "observed", "an", "enhancement", "in", "the", "activation", "of", "C0108342#ent", "<e1>", "by", "the", "proximal", "mutant", "with", "tyrosine", ",", "the", "exogenous", "C0597206#ent", "<e2>", ",", "and", "benzoate", "."], "h": {"id": "C0108342", "name": "C0108342#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0597206", "name": "C0597206#ent", "pos": [23, 24]}}
{"token": ["C0023524#ent", "<e1>", "is", "essential", "for", "p53-dependent", "induction", "of", "C1418401#ent", "<e2>", "gamma-irradiation", "through", "PML-nuclear", "body", "control", "of", "p53", "acetylation", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [8, 9]}}
{"token": ["In", "syndromes", "with", "increased", "extracellular", "fluid", "volume", ",", "such", "as", "C0022661#ent", "<e1>", "distal", "tubular", "rejection", "of", "C3714642#ent", "<e2>", "leads", "to", "a", "progressive", "increase", "in", "its", "fractional", "excretion", "the", "glomerular", "filtration", "rate", "reduced", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [16, 17]}}
{"token": ["Long-term", "treatment", "with", "valproate", "(", "C0042291#ent", "<e1>", ")", "or", "carbamazepine", "(", "CBZ", ")", "may", "induce", "C0236099#ent", "<e2>", "patients", "with", "epilepsy", "."], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0236099", "name": "C0236099#ent", "pos": [15, 16]}}
{"token": ["C0042523#ent", "<e1>", "inhibition", "of", "C1176140#ent", "<e2>", "in", "many", "drug-drug", "interactions", "CYP3A", "substrates", ",", "but", "the", "mechanism", "of", "inhibition", "is", "unclear", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [4, 5]}}
{"token": ["These", "data", "suggest", "that", "C1565306#ent", "<e1>", "phosphorylation", "of", "human", "C1539748#ent", "<e2>", "SEPT5", "at", "S327", "plays", "a", "role", "in", "modulating", "exocytotic", "secretion", "."], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539748", "name": "C1539748#ent", "pos": [9, 10]}}
{"token": ["C1414542#ent", "<e1>", "a", "common", "connective", "tissue", "disease", "different", "musculoskeletal", ",", "ophthalmic", "and", "C0029166#ent", "<e2>"], "h": {"id": "C1414542", "name": "C1414542#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [12, 13]}}
{"token": ["C1414542#ent", "<e1>", "a", "dominantly", "inherited", "connective", "tissue", "disease", "by", "cardiovascular", ",", "skeletal", "and", "C0029166#ent", "<e2>", "which", "was", "firstly", "described", "by", "Antoine", "Marfan", "in", "1896", "."], "h": {"id": "C1414542", "name": "C1414542#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [13, 14]}}
{"token": ["In", "de", "novo", "APL", ",", "the", "b/p", "in", "the", "C0023524#ent", "<e1>", "clustered", "in", "introns", "3", "C0105421#ent", "<e2>", "30", "%", ")", "and", "around", "intron", "6", "bcr", "1", "2", ":", "70", "%", ")", "."], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "case", "of", "C3495801#ent", "<e1>", "WG", ")", ",", "localised", "to", "the", "C1698481#ent", "<e2>", "which", "presented", "as", "an", "unusual", "form", "of", "hyperplastic", "gingivitis", "a", "36-year-old", "female", "."], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1698481", "name": "C1698481#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "C0087031#ent", "<e1>", ",", "insulin-dependent", "diabetes", "mellitus", "IDDM", ")", "are", "at", "high", "risk", "C0010054#ent", "<e2>"], "h": {"id": "C0087031", "name": "C0087031#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [14, 15]}}
{"token": ["Cases", "of", "C0153188#ent", "<e1>", "are", "likely", "to", "be", "ascertained", "through", "C1420519#ent", "<e2>", ",", "antenatal", "and", "refugee", "screening", ",", "rather", "than", "because", "of", "symptoms", "or", "contact", "tracing"], "h": {"id": "C0153188", "name": "C0153188#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420519", "name": "C1420519#ent", "pos": [10, 11]}}
{"token": ["Partial", "cross-reactivity", "between", "porcine", "and", "C0009306#ent", "<e1>", "us", "to", "fractionate", "antibodies", "by", "immunoaffinity", "chromatography", "C2350558#ent", "<e2>", "chicken", "colipase", "."], "h": {"id": "C0009306", "name": "C0009306#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [14, 15]}}
{"token": ["C0154841#ent", "<e1>", "a", "relatively", "common", "C0035309#ent", "<e2>", "the", "elderly", ",", "and", "those", "with", "cardiovascular", "or", "thrombophilic", "risk", "factors", "are", "at", "increased", "risk", "."], "h": {"id": "C0154841", "name": "C0154841#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0035309", "name": "C0035309#ent", "pos": [5, 6]}}
{"token": ["C1834674#ent", "<e1>", "a", "rare", "autosomal", "dominant", "C0206157#ent", "<e2>", "characterized", "by", "slowly", "progressive", "limb-girdle", "muscular", "atrophy", "weakness", ",", "and", "contractures", "of", "multiple", "joints"], "h": {"id": "C1834674", "name": "C1834674#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0206157", "name": "C0206157#ent", "pos": [6, 7]}}
{"token": ["Indirect", "end-labelling", "was", "used", "to", "map", "DNase", "I", "micrococcal", "nuclease", "C2984879#ent", "<e1>", ")", "cleavage", "sites", "the", "transduced", "C0086661#ent", "<e2>", "sequences", "and", "the", "endogenous", "C0086661#ent", "<e2>", "loci", "in", "infected", "HeLa", "cells"], "h": {"id": "C2984879", "name": "C2984879#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [17, 18]}}
{"token": ["A", "14", "kDa", "polypeptide", "in", "rat", "ileal", "cytosol", "been", "identified", "as", "the", "major", "intestinal", "C1414515#ent", "<e1>", "I-BABP", ")", "by", "photoaffinity", "labeling", "the", "radiolabeled", "7,7-azo", "derivative", "of", "C2827312#ent", "<e2>", "(", "7,7-azo-TC", ")", "."], "h": {"id": "C1414515", "name": "C1414515#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2827312", "name": "C2827312#ent", "pos": [26, 27]}}
{"token": ["SS-HCV", "patients", "presented", "a", "more", "restrictive", "monoclonal", "expression", "limited", "to", "either", "monoclonal", "IgMkappa", "or", "monoclonal", "IgGlambda", ")", "than", "primary", "C0085077#ent", "<e1>", "patients", ",", "who", "showed", "all", "types", "of", "heavy", "and", "C0238239#ent", "<e2>"], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0238239", "name": "C0238239#ent", "pos": [30, 31]}}
{"token": ["An", "important", ",", "recent", "advance", "in", "the", "management", "of", "C0004030#ent", "<e1>", "is", "the", "availability", "of", "newer", "broad-spectrum", "azoles", ",", "voriconazole", "and", "C0936148#ent", "<e2>", ",", "which", "have", "good", "activity", "against"], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [9, 10]}, "relation": "may_be_prevented_by", "t": {"id": "C0936148", "name": "C0936148#ent", "pos": [21, 22]}}
{"token": ["We", "identified", "recently", "N-Tes", ",", "which", "is", "a", "product", "of", "testican", "3", "variant", "C0079429#ent", "<e1>", ",", "as", "an", "inhibitor", "of", "membrane-type", "matrix", "metalloproteinases", "C0671550#ent", "<e2>", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0671550", "name": "C0671550#ent", "pos": [23, 24]}}
{"token": ["We", "identified", "recently", "N-Tes", ",", "which", "is", "a", "product", "of", "testican", "3", "variant", "C0079429#ent", "<e1>", ",", "as", "an", "inhibitor", "of", "C0671550#ent", "<e2>", "MT-MMPs", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0671550", "name": "C0671550#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "P-TEFb", "can", "phosphorylate", "the", "C1442905#ent", "<e1>", "of", "RNA", "polymerase", "II", "the", "C1335439#ent", "<e2>", "is", "in", "an", "early", "elongation", "complex", "."], "h": {"id": "C1442905", "name": "C1442905#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [13, 14]}}
{"token": ["6", "Atenolol", "appeared", "almost", "equally", "effective", "to", "C0033497#ent", "<e1>", "in", "the", "management", "of", "the", "C0029166#ent", "<e2>", "hyperthyroidism", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [14, 15]}}
{"token": ["The", "efficacy", "of", "diazepam", ",", "haloperidol", ",", "C0033497#ent", "<e1>", ",", "and", "yohimbine", "in", "antagonizing", "the", "C0029166#ent", "<e2>", "d-amphetamine", "were", "studied", "in", "rats", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [15, 16]}}
{"token": ["These", "results", "provide", "additional", "evidence", "that", "C1413814#ent", "<e1>", "a", "strong", "C2987634#ent", "<e2>", "support", "the", "conclusion", "that", "C1413814#ent", "<e1>", "phospholipase", "C", "and", "clearly", "suggest", "that", "C1413814#ent", "<e1>", "function", "as", "an", "agonist", "in", "vivo"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413814", "name": "C1413814#ent", "pos": [6, 7]}}
{"token": ["Histamine", "H2", "receptor", "blockade", "C0076711#ent", "<e1>", "(", "0.1", "microM", ")", "slightly", "decreased", ",", "while", "C0076502#ent", "<e2>", "(", "1", "microM", ")", ",", "a", "selective", "histamine", "H3", "receptor", "antagonist", "did", "not", "block", "histamine-induced", "dilation", "."], "h": {"id": "C0076711", "name": "C0076711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0076502", "name": "C0076502#ent", "pos": [14, 15]}}
{"token": ["Porcine", "circovirus", "type", "2", "PCV2", ")", "is", "known", "to", "be", "associated", "with", "C1721016#ent", "<e1>", "PMWS", ")", ",", "an", "emerging", "C0039006#ent", "<e2>", "results", "in", "tremendous", "economic", "losses"], "h": {"id": "C1721016", "name": "C1721016#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039006", "name": "C0039006#ent", "pos": [19, 20]}}
{"token": ["Human", "DDX3", "(", "hDDX3", ")", "is", "a", "C1438415#ent", "<e1>", "to", "possess", "RNA-unwinding", "and", "adenosine", "triphosphatase", "C0001473#ent", "<e2>", ")", "activities", "."], "h": {"id": "C1438415", "name": "C1438415#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "the", "possible", "side", "effects", "efficacy", "of", "arterial", "infusion", "C0071449#ent", "<e1>", "as", "compared", "to", "Lipiodol", "+", "C0014582#ent", "<e2>", "TAE", "for", "multiple", "recurrent", "tumors", "hepatic", "resection"], "h": {"id": "C0071449", "name": "C0071449#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [17, 18]}}
{"token": ["We", "have", "affirmed", "that", "simvastatin", "decreased", "of", "tADA", "activity", "by", "50", "%", ",", "C0050537#ent", "<e1>", "34", "%", ",", "metoprolol", "by", "29.1", "%", "and", "C0022251#ent", "<e2>", "mononitrate", "by", "19.3", "%", "."], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022251", "name": "C0022251#ent", "pos": [23, 24]}}
{"token": ["One", "exhibited", "a", "C0037928#ent", "<e1>", "and", "the", "other", "C0014130#ent", "<e2>", "Schmidt's", "syndrome", "followed", "by", "a", "neuropsychiatric", "and", "dementing", "disorder", "to", "cerebral", "perivascular", "demyelination", "."], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [8, 9]}}
{"token": ["Thirty-nine", "patients", "with", "C0033860#ent", "<e1>", "were", "treated", "either", "with", "C0051556#ent", "<e2>", "percent", "twice", "a", "day", "or", "with", "fluocinonide", "ointment", "percent", "three", "times", "a", "day", "in", "a", "two-week", ",", "randomized", ",", "parallel-group", ",", "double-blind", "study"], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0051556", "name": "C0051556#ent", "pos": [9, 10]}}
{"token": ["The", "incidence", "of", "C0004610#ent", "<e1>", "control", "cats", "that", "B.", "henselae", "C0004610#ent", "<e1>", "is", "prevalent", "among", "the", "domestic", "cat", "population", "in", "the", "United", "States"], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [3, 4]}}
{"token": ["This", "report", "reviews", "the", "clinical", "spectrum", "C0004610#ent", "<e1>", "which", "can", "range", "from", "mild", ",", "possibly", "self-limiting", "C0004610#ent", "<e1>", "to", "serious", ",", "life-threatening", "septicaemia", ",", "especially", "in", "compromised", "hospitalized", "patients", "."], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [6, 7]}}
{"token": ["Oxygen", "consumption", "phase", "I", "inhibited", "by", "C3253705#ent", "<e1>", "and", "5,5-dimethyl-1-pyrroline", "N-oxide", ",", "but", "not", "by", "C0024730#ent", "<e2>", ";", "superoxide", "dismutase", "inhibited", "oxygen", "consumption", "phase", "I", "while", "catalase", "added", "during", "phase", "II", "decreased", "the", "rate", "of", "oxygen", "consumption"], "h": {"id": "C3253705", "name": "C3253705#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024730", "name": "C0024730#ent", "pos": [15, 16]}}
{"token": ["These", "levels", "were", "in", "turn", "each", "significantly", "reduced", "by", "the", "addition", "of", "60", "mM", "C3253705#ent", "<e1>", ",", "3", "mM", "uric", "acid", "and", "100", "mM", "C0024730#ent", "<e2>", "to", "the", "flush", "solution"], "h": {"id": "C3253705", "name": "C3253705#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024730", "name": "C0024730#ent", "pos": [24, 25]}}
{"token": ["Glomerular", "function", "48", "h", "after", "reperfusion", "was", "significantly", "better", "after", "pretreatment", "with", "C3253705#ent", "<e1>", "and", "C0024730#ent", "<e2>", "compared", "with", "C0024730#ent", "<e2>", "alone", "."], "h": {"id": "C3253705", "name": "C3253705#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024730", "name": "C0024730#ent", "pos": [15, 16]}}
{"token": ["Charcot-Marie-Tooth", "disease", "classified", "into", "hereditary", "motor", "sensory", "neuropathy", "C0037773#ent", "<e1>", ")", "types", "I", "and", "C3273406#ent", "<e2>", ",", "and", "affected", "patients", "present", "with", "progressive", "peripheral", "neuropathy"], "h": {"id": "C0037773", "name": "C0037773#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [14, 15]}}
{"token": ["A", "guinea", "pig", "model", "of", "nerve", "damage", "C0023343#ent", "<e1>", "has", "been", "used", "to", "investigate", "the", "expression", "of", "C0024518#ent", "<e2>", "MHC", ")", "class", "II", "antigens", "in", "granulomatous", "lesions", "nerves", "."], "h": {"id": "C0023343", "name": "C0023343#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [17, 18]}}
{"token": ["A", "considerable", "number", "of", "studies", "have", "postulated", "significant", "associations", "between", "susceptibility", "to", "the", "different", "clinical", "manifestations", "C0023343#ent", "<e1>", "and", "the", "C0024518#ent", "<e2>", "."], "h": {"id": "C0023343", "name": "C0023343#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [20, 21]}}
{"token": ["Irradiation", "in", "a", "dose", "of", "5", "Gy", "did", "not", "alter", "the", "activity", "of", "C0538674#ent", "<e1>", "caused", "a", "negligible", "reduction", "in", "the", "activity", "of", "C0002565#ent", "<e2>"], "h": {"id": "C0538674", "name": "C0538674#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002565", "name": "C0002565#ent", "pos": [23, 24]}}
{"token": ["OA-NO2", "also", "induced", "PPAR", "gamma-dependent", "adipogenesis", "and", "C0011501#ent", "<e1>", "uptake", "in", "3T3-L1", "C1414069#ent", "<e2>", "at", "a", "potency", "exceeding", "nitrolinoleic", "acid", "rivaling", "synthetic", "thiazo-lidinediones", "."], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414069", "name": "C1414069#ent", "pos": [12, 13]}}
{"token": ["The", "objective", "of", "the", "present", "study", "was", "to", "evaluate", "the", "hemodynamic", "and", "neurohormonal", "response", "to", "C0126174#ent", "<e1>", "in", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["The", "C0126174#ent", "<e1>", "Survival", "Study", "ELITE", "II", ")", "and", "the", "C0018802#ent", "<e2>", "Val-HeFT", ")", "both", "evaluated", "the", "efficacy", "and", "tolerability", "of", "a", "selective", "angiotensin", "II", "receptor", "antagonist", "morbidity", "and", "mortality", "in", "patients", "with", "symptomatic", "heart", "failure"], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [10, 11]}}
{"token": ["C0669372#ent", "<e1>", "iNOS", ")", "is", "activated", "in", "C0018799#ent", "<e2>"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [7, 8]}}
{"token": ["These", "studies", "show", "that", "EB-1053", "is", "a", "very", "potent", "C2267018#ent", "<e1>", "that", "has", "potential", "use", "in", "the", "treatment", "of", "C0263661#ent", "<e2>"], "h": {"id": "C2267018", "name": "C2267018#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [19, 20]}}
{"token": ["Of", "the", "96", "cryopreserved", "embryos", ",", "82", "were", "thawed", "for", "ET", ",", "and", "45", "C1332416#ent", "<e1>", "embryos", "were", "transferred", "in", "32", "C1705691#ent", "<e2>", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705691", "name": "C1705691#ent", "pos": [21, 22]}}
{"token": ["Urinary", "and", "plasma", "thiols", "(", "C0019880#ent", "<e1>", ",", "Cys", "and", "C1622105#ent", "<e2>", ")", "were", "assayed", "by", "HPLC", "."], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [10, 11]}}
{"token": ["We", "have", "shown", "that", "activation", "of", "the", "EGFR", "induces", "up-regulation", "of", "C0387583#ent", "<e1>", "basolateral", "release", "of", "prostaglandins", "(", "C0796254#ent", "<e2>", ")", ",", "and", "mitogenesis", "in", "a", "polarizing", "human", "colon", "cancer", "cell", "line", "HCA-7", "."], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [18, 19]}}
{"token": ["FR50", "decreased", "at", "term", "both", "the", "maternal", "plasma", "C1413150#ent", "<e1>", "level", "and", "C0608861#ent", "<e2>", "expression", "."], "h": {"id": "C1413150", "name": "C1413150#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0608861", "name": "C0608861#ent", "pos": [12, 13]}}
{"token": ["Such", "effects", "correlated", "with", "activation", "of", "the", "C0086376#ent", "<e1>", "and", "downstream", "engagement", "of", "the", "C1434639#ent", "<e2>", "whose", "function", "was", "found", "to", "be", "essential", "for", "the", "generation", "of", "proapoptotic", "responses", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1434639", "name": "C1434639#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "the", "effect", "of", "TNFalpha", "on", "C1705592#ent", "<e1>", "is", "responsible", "for", "the", "regulation", "of", "the", "expression", "of", "C1332712#ent", "<e2>", "isoforms", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332712", "name": "C1332712#ent", "pos": [20, 21]}}
{"token": ["Twelve", "healthy", "male", "volunteers", "received", "three", "200-mg", "capsules", "of", "C0003420#ent", "<e1>", "on", "days", "1", "and", "22", ",", "and", "two", "40-mg", "C2698196#ent", "<e2>", "tablets", "in", "the", "morning", "on", "days", "8", "through", "23", "."], "h": {"id": "C0003420", "name": "C0003420#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2698196", "name": "C2698196#ent", "pos": [20, 21]}}
{"token": ["C0009014#ent", "<e1>", "was", "given", "to", "patients", "with", "essential", "hypertension", "C0020538#ent", "<e2>", "and", "hypertension", "with", "parenchymal", "renal", "disease"], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}}
{"token": ["enalaprilat", "and", "transdermal", "C0009014#ent", "<e1>", "on", "a", "chronic", "basis", "to", "C0020538#ent", "<e2>"], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "retrospectively", "the", "efficacy", "of", "expandable", "metallic", "stents", "C1869115#ent", "<e1>", ")", "for", "severe", "respiratory", "distress", "patients", "with", "C0001883#ent", "<e2>"], "h": {"id": "C1869115", "name": "C1869115#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [24, 25]}}
{"token": ["The", "localization", "of", "sodium", "channels", "C0234238#ent", "<e1>", ")", "change", "following", "C0847483#ent", "<e2>", "this", "change", "may", "contribute", "to", "the", "development", "of", "increased", "pain", "states"], "h": {"id": "C0234238", "name": "C0234238#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0847483", "name": "C0847483#ent", "pos": [10, 11]}}
{"token": ["C0059040#ent", "<e1>", "EF-Ts", ")", "is", "the", "guanine-nucleotide", "exchange", "factor", "elongation", "factor", "Tu", "C1705442#ent", "<e2>", ")", ",", "which", "promotes", "the", "binding", "of", "aminoacyl-tRNA", "to", "the", "mRNA-programmed", "ribosome", "in", "prokaryotes", "."], "h": {"id": "C0059040", "name": "C0059040#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705442", "name": "C1705442#ent", "pos": [12, 13]}}
{"token": ["Several", "new", "medications", "show", "promise", "as", "alternatives", "to", "C0006949#ent", "<e1>", ",", "which", "has", "been", "the", "standard", "first-line", "treatment", "C0040997#ent", "<e2>", ",", "while", "electromagnetic", "pulsed", "radiofrequency", "gamma", "knife", "surgery", "new", "options", "when", "the", "surgical", "route", "warranted", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0040997", "name": "C0040997#ent", "pos": [18, 19]}}
{"token": ["Adverse", "reactions", "clinical", "significance", "two", "cases", "of", "leukopenia", "and", "one", "case", "each", "of", "C0242528#ent", "<e1>", ",", "diarrhoea", "(", "Clostridium", "difficile", "toxin", "positive", ")", ",", "and", "C0521471#ent", "<e2>", "."], "h": {"id": "C0242528", "name": "C0242528#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0521471", "name": "C0521471#ent", "pos": [25, 26]}}
{"token": ["As", "regard", "human", "pathology", "the", "efficacy", "of", "ademethionine", "was", "demonstrated", "firstly", "in", "C0268312#ent", "<e1>", "pregnancy", "or", "C1825684#ent", "<e2>", "and", "later", "on", "in", "hepatic", "diseases", "different", "etiology", "."], "h": {"id": "C0268312", "name": "C0268312#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1825684", "name": "C1825684#ent", "pos": [16, 17]}}
{"token": ["The", "secretion", "of", "17", "C1738873#ent", "<e1>", "and", "C19-steroids", "is", "enhanced", "further", "by", "an", "action", "of", "C1704793#ent", "<e2>", "to", "increase", "17", "alpha-hydroxylase", "activity", "possibly", "also", "17,20-lyase", "activity"], "h": {"id": "C1738873", "name": "C1738873#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [15, 16]}}
{"token": ["We", "have", "studied", "the", "GH-dependent", "expression", "of", "C0059563#ent", "<e1>", "P-450(15)beta", ")", "mRNA", "and", "insulin-like", "growth", "factor-I", "C1334089#ent", "<e2>", ")", "mRNA", "in", "primary", "adult", "rat", "hepatocytes", "."], "h": {"id": "C0059563", "name": "C0059563#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [16, 17]}}
{"token": ["This", "study", "compared", "a", "10", "%", "C0008196#ent", "<e1>", "treatment", "with", "placebo", "and", "sham", "treatments", "for", "preventing", "C0011334#ent", "<e2>", "adult", "patients", "with", "xerostomia", "(", "dry", "mouth", "."], "h": {"id": "C0008196", "name": "C0008196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011334", "name": "C0011334#ent", "pos": [16, 17]}}
{"token": ["The", "mRNA", "and", "protein", "expression", "NGF", ",", "C1704884#ent", "<e1>", "and", "Fas", "increased", ",", "but", "expression", "of", "C1704467#ent", "<e2>", "decreased", "."], "h": {"id": "C1704884", "name": "C1704884#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [16, 17]}}
{"token": ["C1704884#ent", "<e1>", "stimulation", "up-regulates", "the", "expression", "of", "the", "anti-apoptotic", "Bcl-2", "family", "members", "C1704467#ent", "<e2>", ",", "Bcl-XL", ",", "and", "Bfl-1", "."], "h": {"id": "C1704884", "name": "C1704884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [12, 13]}}
{"token": ["Blocking", "of", "NGF-mediated", "signaling", "through", "C1704884#ent", "<e1>", "prevents", "Bcl-2-associated", "expression", "in", "differentiation-associated", "genes", "raising", "the", "possibility", "that", "C1704467#ent", "<e2>", "mediates", "induction", "of", "neural", "differentiation", "TrkA/NGF", "signaling", "."], "h": {"id": "C1704884", "name": "C1704884#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [17, 18]}}
{"token": ["The", "possible", "contribution", "of", "C1565489#ent", "<e1>", "the", "pathogenesis", "of", "C0029166#ent", "<e2>", "GVHD", "is", "discussed", "."], "h": {"id": "C1565489", "name": "C1565489#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [9, 10]}}
{"token": ["The", "polyamine", "spermine", "the", "disulfide", "N", "N\"-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine", "(", "C0078538#ent", "<e1>", ")", "are", "structurally", "similar", "C0991617#ent", "<e2>", "capable", "of", "binding", "to", "DNA", "."], "h": {"id": "C0078538", "name": "C0078538#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [14, 15]}}
{"token": ["This", "case", "highlights", "a", "rare", "ocular", "complication", "associated", "with", "C0041323#ent", "<e1>", "fortunately", "did", "not", "result", "in", "C0042798#ent", "<e2>", "to", "prompt", "treatment", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042798", "name": "C0042798#ent", "pos": [16, 17]}}
{"token": ["On", "the", "basis", "of", "their", "own", "experience", "they", "deal", "in", "details", "with", "C0003886#ent", "<e1>", "amyoplasia", "which", "differs", "from", "C1285162#ent", "<e2>", "3", "symptoms", ":", "1", "."], "h": {"id": "C0003886", "name": "C0003886#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [18, 19]}}
{"token": ["Also", "there", "was", "an", "increase", "in", "the", "expression", "of", "transcripts", "encoding", "enzymes", "such", "as", "C1701621#ent", "<e1>", "mGST", "1", ")", "and", "C0049866#ent", "<e2>", "7-DHCR", ")", "during", "this", "process", "."], "h": {"id": "C1701621", "name": "C1701621#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0049866", "name": "C0049866#ent", "pos": [20, 21]}}
{"token": ["Effective", "treatment", "options", "include", "cognitive", "behavioral", "therapy", "C1412770#ent", "<e1>", ")", "and", "pharmacotherapy", "with", "C0162758#ent", "<e2>", "SRIs", ")", "."], "h": {"id": "C1412770", "name": "C1412770#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [13, 14]}}
{"token": ["Before", "surgery", ",", "all", "patients", "received", "an", "interscalene", "block", "ISB", ")", "with", "either", "40", "mL", "of", "0.6", "%", "C0073571#ent", "<e1>", "or", "40", "mL", "of", "0.5", "%", "C0887621#ent", "<e2>", "."], "h": {"id": "C0073571", "name": "C0073571#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0887621", "name": "C0887621#ent", "pos": [26, 27]}}
{"token": ["In", "general", ",", "C0073571#ent", "<e1>", "is", "less", "potent", "than", "C0887621#ent", "<e2>", "but", "more", "potent", "than", "lidocaine", "in", "terms", "of", "its", "depressant", "effect", "on", "cardiac", "excitation", "conduction", "."], "h": {"id": "C0073571", "name": "C0073571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0887621", "name": "C0887621#ent", "pos": [9, 10]}}
{"token": ["In", "most", "recent", "studies", ",", "C0073571#ent", "<e1>", "exhibited", "a", "very", "close", "pharmacodynamic", "profile", "equipotent", "doses", "of", "C0887621#ent", "<e2>", "."], "h": {"id": "C0073571", "name": "C0073571#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0887621", "name": "C0887621#ent", "pos": [16, 17]}}
{"token": ["C1413057#ent", "<e1>", "of", "less", "than", "15", ",", "C1433276#ent", "<e2>", "of", "less", "than", "12", ",", "and", "PTS", "of", "less", "than", "9", "are", "equally", "sensitive", "and", "specific", "indicators", "for", "pediatric", "prehospital", "triage", "."], "h": {"id": "C1413057", "name": "C1413057#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1433276", "name": "C1433276#ent", "pos": [7, 8]}}
{"token": ["We", "found", "that", "TCF4E", "but", "not", "C1384617#ent", "<e1>", "supported", "beta-catenin-dependent", "activation", "of", "the", "C1413301#ent", "<e2>", "promoter", ",", "whereas", "C1384617#ent", "<e1>", "specifically", "activated", "the", "Siamois", "promoter", "."], "h": {"id": "C1384617", "name": "C1384617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413301", "name": "C1413301#ent", "pos": [13, 14]}}
{"token": ["To", "analyse", "the", "regulation", "of", "C1333577#ent", "<e1>", "in", "vitro", "we", "have", "purified", "Fyn", "and", "Csk", ",", "a", "C0211705#ent", "<e2>", "capable", "of", "regulating", "Fyn", "activity", "by", "phosphorylation", ",", "from", "baculovirus-infected", "insect", "cells", "."], "h": {"id": "C1333577", "name": "C1333577#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [17, 18]}}
{"token": ["The", "site", "of", "this", "blockade", "was", "investigated", "by", "examining", "the", "effect", "of", "PMA", "on", "guanine", "nucleotide-stimulated", "formation", "and", "on", "phosphoinositide-specific", "phospholipase", "C", "C3810542#ent", "<e1>", ")", "activity", "in", "C1420259#ent", "<e2>", "membranes", "."], "h": {"id": "C3810542", "name": "C3810542#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1420259", "name": "C1420259#ent", "pos": [27, 28]}}
{"token": ["Eukaryotic", "elongation", "factor", "1", "C1414290#ent", "<e1>", ")", "contains", "the", "C0120465#ent", "<e2>", "eEF-1B", "that", "loads", "the", "G", "protein", "eEF-1A", "with", "GTP", "after", "each", "cycle", "of", "elongation", "during", "protein", "synthesis"], "h": {"id": "C1414290", "name": "C1414290#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [9, 10]}}
{"token": ["C1412812#ent", "<e1>", "(", "nineteen", "kD", "interacting", "C2350436#ent", "<e2>", ")", "is", "an", "E1B", "19", "K", "and", "Bcl-2", "binding", "protein", "unknown", "function", "."], "h": {"id": "C1412812", "name": "C1412812#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2350436", "name": "C2350436#ent", "pos": [6, 7]}}
{"token": ["Urinary", "calcium", "Ca", ")", "excretion", "and", "erythrocyte", "membrane", "Ca", "binding", "transport", "were", "investigated", "in", "rats", "of", "the", "C0003364#ent", "<e1>", "MHS", ")", "and", "normotensive", "strains", "(", "C1415376#ent", "<e2>", ")", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415376", "name": "C1415376#ent", "pos": [25, 26]}}
{"token": ["Administration", "of", "estradiol", "increased", "TGFbeta3-immunoreactive", "cell", "numbers", ",", "TGFbeta3", "protein", "and", "C1710291#ent", "<e1>", "messenger", "RNA", "in", "the", "C0032002#ent", "<e2>", "."], "h": {"id": "C1710291", "name": "C1710291#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [17, 18]}}
{"token": ["The", "pharmacological", "profile", "the", "5-HT", "receptor", "the", "inhibition", "of", "C1382029#ent", "<e1>", "substantia", "nigra", "that", "this", "receptor", "probably", "corresponds", "to", "C1415804#ent", "<e2>", "binding", "sites"], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415804", "name": "C1415804#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", "to", "diacylphosphatidylcholines", ",", "the", "Tp", "for", "C0068006#ent", "<e1>", "was", "lowered", "by", "C1420357#ent", "<e2>", ",", "demonstrating", "that", "the", "latter", "destabilizes", "the", "interdigitated", "gel", "phase", "."], "h": {"id": "C0068006", "name": "C0068006#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420357", "name": "C1420357#ent", "pos": [13, 14]}}
{"token": ["The", "levels", "of", "C1823832#ent", "<e1>", "differed", "significantly", "between", "C0812385#ent", "<e2>", "and", "AML", "(", "P", "<", "0.001", ")", ",", "the", "C0812385#ent", "<e2>", "cases", "being", "all", "CAF7intermediate", "or", "CAF7high", "."], "h": {"id": "C1823832", "name": "C1823832#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [8, 9]}}
{"token": ["The", "increased", "C0086376#ent", "<e1>", "in", "A549", "were", "aldehyde", "dehydrogenase", "peroxiredoxin", "I", "fatty", "acid", "binding", "protein", "aldoketoreductase", ",", "and", "C1423702#ent", "<e2>", ",", "whereas", "the", "decreased", "C0086376#ent", "<e1>", "were", "galectin-1", ",", "transgelin", ",", "and", "stathmin", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423702", "name": "C1423702#ent", "pos": [18, 19]}}
{"token": ["Campylobacter", "upsaliensis", "a", "recently", "recognized", "human", "enteric", "pathogen", "associated", "with", "C0014335#ent", "<e1>", ",", "colitis", ",", "bacteremia", ",", "and", "C0036690#ent", "<e2>", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [18, 19]}}
{"token": ["A", "case", "of", "C0014335#ent", "<e1>", "necroticans", "presenting", "with", "midgut", "necrosis", "with", "C0036690#ent", "<e2>", "and", "hemolysis", "is", "reported", "herein", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [11, 12]}}
{"token": ["A", "56-year-old", "woman", "with", "C0026269#ent", "<e1>", "admitted", "for", "cerebral", "infarction", "C0000737#ent", "<e2>"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [10, 11]}}
{"token": ["A", "46-year-old", "woman", ",", "who", "had", "been", "treated", "with", "anti-arrhythmic", "drugs", "digitalis", "for", "C0026269#ent", "<e1>", "paroxysmal", "atrial", "fibrillation", "suddenly", "developed", "severe", "C0000737#ent", "<e2>", "nausea", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [21, 22]}}
{"token": ["This", "C0298690#ent", "<e1>", "dsPTPase", ")", "and", "other", "members", "of", "the", "C1335554#ent", "<e2>", "PTPases", ")", "have", "only", "recently", "joined", "the", "protease", "and", "kinase", "enzyme", "families", "in", "drug", "discovery", "."], "h": {"id": "C0298690", "name": "C0298690#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [10, 11]}}
{"token": ["C0085622#ent", "<e1>", "exclusively", "the", "lower", "C0030196#ent", "<e2>", ",", "with", "no", "nervous", "system", "elsewhere", "and", "a", "relatively", "benign", "prognosis", "."], "h": {"id": "C0085622", "name": "C0085622#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [5, 6]}}
{"token": ["Like", "C0034678#ent", "<e1>", "PML", "increased", "the", "levels", "of", "C1705280#ent", "<e2>", ",", "hypophosphorylated", "Rb", ",", "phosphoserine-15", "p53", ",", "and", "expression", "of", "p53", "transcriptional", "targets", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [8, 9]}}
{"token": ["However", ",", "the", "effect", "of", "C0036690#ent", "<e1>", "or", "burn", "injury", "the", "expression", "of", "C3887565#ent", "<e2>", "PGDH", ")", ",", "the", "key", "enzyme", "responsible", "for", "PGE2", "degradation", ",", "has", "not", "been", "explored", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3887565", "name": "C3887565#ent", "pos": [13, 14]}}
{"token": ["Autosomal-dominant", "medullary", "cystic", "kidney", "disease", "type", "2", "MCKD2", ")", "is", "a", "C0041349#ent", "<e1>", "causes", "renal", "salt", "wasting", "hyperuricemia", ",", "C0018099#ent", "<e2>", ",", "and", "end-stage", "renal", "failure", "the", "fifth", "decade", "of", "life", "."], "h": {"id": "C0041349", "name": "C0041349#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [19, 20]}}
{"token": ["Renal", "function", "biopsy", "studies", "showed", "that", "lead", "nephropathy", "is", "a", "C0041349#ent", "<e1>", "modest", "proteinuria", "which", "frequently", "presents", "with", "hyperuricemia", ",", "C0018099#ent", "<e2>", "and", "hypertension", "."], "h": {"id": "C0041349", "name": "C0041349#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [20, 21]}}
{"token": ["C1424858#ent", "<e1>", "comprises", "four", "single-stranded", "DNA-binding", "domains", "while", "C1419619#ent", "<e2>", "and", "RPA3", "are", "each", "composed", "of", "two", "such", "domains", "and", "a", "zinc", "finger", "domain"], "h": {"id": "C1424858", "name": "C1424858#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419619", "name": "C1419619#ent", "pos": [8, 9]}}
{"token": ["There", "is", "a", "marked", "increase", "in", "the", "acidic", "alpha-D-mannosidase", "the", "plasma", "of", "a", "patient", "with", "C0020725#ent", "<e1>", "of", "a", "patient", "with", "C0033788#ent", "<e2>"], "h": {"id": "C0020725", "name": "C0020725#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0033788", "name": "C0033788#ent", "pos": [21, 22]}}
{"token": ["This", "candidate", "region", "overlapped", "with", "a", "previously", "reported", "locus", "for", "C0009952#ent", "<e1>", "FEB4", ")", "in", "the", "Japanese", "population", ",", "in", "which", "C1825092#ent", "<e2>", "was", "proposed", "as", "disease", "gene"], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1825092", "name": "C1825092#ent", "pos": [21, 22]}}
{"token": ["C1254351#ent", "<e1>", "concentrations", "of", "CMI", "and", "C0123091#ent", "<e2>", "were", "significantly", "increased", "and", "pharmacogenetic", "testing", "a", "poor", "metabolizer", "status", "for", "CYP2D6", ",", "low", "CYP3A4/5", "activity", "and", "normal", "CYP2C19", "genotype", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0123091", "name": "C0123091#ent", "pos": [6, 7]}}
{"token": ["However", ",", "the", "lack", "of", "rise", "of", "plasma", "noradrenaline", "C0026454#ent", "<e1>", ",", "except", "in", "the", "patients", "with", "pure", "C0037019#ent", "<e2>", "clearly", "separates", "these", "responses", "from", "those", "of", "normal", "subjects"], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [18, 19]}}
{"token": ["Testing", "of", "current", "H5N1", "avian", "influenza", "virus", "isolates", ",", "the", "potential", "C0991617#ent", "<e1>", "of", "pandemic", "influenza", "suggests", "susceptibility", "to", "C0874161#ent", "<e2>", "and", "zanamivir", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0874161", "name": "C0874161#ent", "pos": [19, 20]}}
{"token": ["The", "expression", "of", "C3540471#ent", "<e1>", "and", "that", "of", "C1416487#ent", "<e2>", "were", "diminished", "in", "response", "to", "Con", "A", "stimulation", "in", "uPA-/-", "mice", "as", "compared", "with", "uPA+/+", "mice", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416487", "name": "C1416487#ent", "pos": [8, 9]}}
{"token": ["The", "quantities", "of", "150-residue", "and", "106-residue", "C1367466#ent", "<e1>", "and", "of", "C0075188#ent", "<e2>", ",", "which", "became", "incorporated", "into", "experimental", "pellicles", "from", "saliva", ",", "were", "estimated", "with", "use", "of", "radiolabeled", "protein", "tracers"], "h": {"id": "C1367466", "name": "C1367466#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0075188", "name": "C0075188#ent", "pos": [10, 11]}}
{"token": ["The", "present", "study", "examined", "the", "effect", "of", "C2936882#ent", "<e1>", "upon", "the", "circadian", "rhythm", "rat", "myocardial", "C1334332#ent", "<e2>", "and", "upon", "the", "endothelial-bound", "and", "tissue", "components", "of", "rat", "myocardial", "C1334332#ent", "<e2>", "immediately", "after", "exhaustive", "exercise", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [15, 16]}}
{"token": ["C2936882#ent", "<e1>", "markedly", "decreased", "the", "amounts", "of", "fat", "accumulation", "and", "lipoprotein", "lipase", "C1334332#ent", "<e2>", ")", "mRNA", "as", "well", "as", "triglyceride", "accumulation", "in", "genetically", "manipulated", "3T3-L1", "adipocytes", "stably", "expressing", "the", "estrogen", "receptor", "ER", ")", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [12, 13]}}
{"token": ["Other", "findings", "were", "normal", "blood", "pressure", "high", "levels", "of", "plasma", "renin", "activity", "and", "serum", "aldosterone", "a", "fall", "in", "blood", "pressure", "C0815017#ent", "<e1>", "infusion", ",", "blunted", "C0237795#ent", "<e2>", "response", "to", "angiotensin", "II", "infusion", "and", "hyperplasia", "of", "the", "juxtaglomerular", "cells"], "h": {"id": "C0815017", "name": "C0815017#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [25, 26]}}
{"token": ["Unlike", "C0815017#ent", "<e1>", "losartan", "did", "not", "exert", "C0237795#ent", "<e2>", "action", "."], "h": {"id": "C0815017", "name": "C0815017#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "part", "of", "the", "C0524928#ent", "<e1>", "from", "C1336642#ent", "<e2>", "is", "incorporated", "into", "amino", "acids", "proteins", ",", "decreasing", "the", "C0524928#ent", "<e1>", "stored", "as", "C1336642#ent", "<e2>", "and", "increasing", "the", "C0524928#ent", "<e1>", "stored", "as", "amino", "acids", "proteins", "."], "h": {"id": "C1336642", "name": "C1336642#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [5, 6]}}
{"token": ["C1420865#ent", "<e1>", "bound", "a", "98amino", "acid", "segment", "from", "C1420865#ent", "<e1>", "."], "h": {"id": "C1420865", "name": "C1420865#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420865", "name": "C1420865#ent", "pos": [0, 1]}}
{"token": ["To", "investigate", "the", "molecular", "mechanism(s", ")", "by", "which", "expression", "of", "C1420865#ent", "<e1>", "colony", "formation", ",", "we", "established", "stable", "cell", "lines", "inducibly", "express", "C1420865#ent", "<e1>", "."], "h": {"id": "C1420865", "name": "C1420865#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420865", "name": "C1420865#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "the", "successful", "treatment", "of", "C0000833#ent", "<e1>", "an", "immunocompetent", "older", "people", "pneumoconiosis", "by", "combining", "C0041044#ent", "<e2>", "and", "ciprofloxacin", "."], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [15, 16]}}
{"token": ["It", "is", "concluded", "that", "long-term", "nifedipine", "treatment", "improves", "left", "ventricular", "function", "leads", "to", "regression", "of", "established", "C0149721#ent", "<e1>", "hypertrophic", "non-obstructive", "cardiomyopathy", "in", "C0020538#ent", "<e2>"], "h": {"id": "C0149721", "name": "C0149721#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [22, 23]}}
{"token": ["A", "total", "of", "381", "C3714496#ent", "<e1>", "patients", ",", "aged", "73+/-6", "C1337037#ent", "<e2>", ",", "were", "classified", "in", "the", "five", "GOLD", "stages", "."], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1337037", "name": "C1337037#ent", "pos": [10, 11]}}
{"token": ["These", "comprise", "for", "example", ",", "seprase", ",", "fibroblast", "activation", "protein", "alpha", "DPP6", ",", "DPP8", ",", "DPP9", ",", "attractin", ",", "C1310550#ent", "<e1>", "II", "and", "L", ",", "C1423031#ent", "<e2>", "thymus-specific", "serine", "protease", "DPP", "IV-beta", "."], "h": {"id": "C1310550", "name": "C1310550#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1423031", "name": "C1423031#ent", "pos": [25, 26]}}
{"token": ["The", "effects", "of", "acute", "C0002598#ent", "<e1>", "infusion", "on", "dynamics", "of", "ventricular", "fibrillation", "C0042510#ent", "<e2>", ")", "are", "unclear", "."], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [12, 13]}}
{"token": ["These", "extracts", ",", "therefore", ",", "produce", "higher", "C0035379#ent", "<e1>", "values", "than", "do", "equivalent", "volumes", "of", "C3541397#ent", "<e2>", "delivered", "neat", "or", "dissolved", "in", "organic", "solvent"], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3541397", "name": "C3541397#ent", "pos": [15, 16]}}
{"token": ["In", "the", "third", "regimen", ",", "etoposide", "and", "C0064039#ent", "<e1>", "were", "given", "for", "six", "courses", "(", "C3811108#ent", "<e2>", ")", "."], "h": {"id": "C0064039", "name": "C0064039#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811108", "name": "C3811108#ent", "pos": [15, 16]}}
{"token": ["C1457887#ent", "<e1>", "this", "childhood", "C0012624#ent", "<e2>", "form", "the", "triad", ":", "unexplained", "fever", ",", "increased", "erythrocyte", "sedimentation", "rate", "and", "symptomatic", "narrowing", "of", "an", "intervertebral", "space"], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012624", "name": "C0012624#ent", "pos": [4, 5]}}
{"token": ["The", "patient", "recovered", "within", "a", "few", "days", ";", "however", "prognosis", "can", "be", "severe", "when", "C0024534#ent", "<e1>", "complicating", "the", "course", "of", "C0858321#ent", "<e2>"], "h": {"id": "C0024534", "name": "C0024534#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0858321", "name": "C0858321#ent", "pos": [20, 21]}}
{"token": ["C0012271#ent", "<e1>", "as", "most", "used", "C0013227#ent", "<e2>", "shall", "be", "applied", "by", "a", "second", "pump", "."], "h": {"id": "C0012271", "name": "C0012271#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [5, 6]}}
{"token": ["Indications", "include", "C0021167#ent", "<e1>", "despite", "pharmacologic", "manipulation", "persistent", "hydroureteronephrosis", ",", "C1970483#ent", "<e2>", "and", "propantheline", "bromide", "intolerance", "."], "h": {"id": "C0021167", "name": "C0021167#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1970483", "name": "C1970483#ent", "pos": [10, 11]}}
{"token": ["Therefore", ",", "CpcSU", "is", "the", "bilin", "lyase-responsible", "for", "attachment", "of", "C1418288#ent", "<e1>", "to", "Cys-82", "of", "CpcB", "and", "Cys-81", "of", "C1720416#ent", "<e2>", "and", "ApcB."], "h": {"id": "C1418288", "name": "C1418288#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1720416", "name": "C1720416#ent", "pos": [19, 20]}}
{"token": ["Other", "commonly", "used", "therapeutic", "agents", "including", "the", "penicillins", ",", "other", "antibiotics", ",", "and", "C3536840#ent", "<e1>", "produce", "renal", "dysfunction", "inducing", "C0041349#ent", "<e2>"], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041349", "name": "C0041349#ent", "pos": [19, 20]}}
{"token": ["Whey", "acidic", "protein", "WAP", ")", "is", "a", "major", "whey", "protein", "milk", "that", "has", "structural", "similarity", "to", "the", "family", "of", "C0033607#ent", "<e1>", "WAP", "motif", "domains", "by", "a", "C1336986#ent", "<e2>"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1336986", "name": "C1336986#ent", "pos": [26, 27]}}
{"token": ["Eppin", "(", "C0033607#ent", "<e1>", "is", "a", "member", "of", "the", "whey", "acidic", "protein", "four-disulfide", "core", "C1336986#ent", "<e2>", ")", "gene", "family"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336986", "name": "C1336986#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "study", ",", "we", "found", "that", "electroacupuncture", "(", "EA", ")", "treatment", "could", "up-regulate", "C1704884#ent", "<e1>", "expression", "after", "C0007785#ent", "<e2>", "rats", "."], "h": {"id": "C1704884", "name": "C1704884#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [19, 20]}}
{"token": ["This", "property", "could", "be", "mimicked", "by", "the", "addition", "of", "C1705556#ent", "<e1>", ",", "implying", "that", "compaction", "via", "C1413019#ent", "<e2>", "and", "C1705556#ent", "<e1>", "is", "part", "of", "the", "activation", "process"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413019", "name": "C1413019#ent", "pos": [16, 17]}}
{"token": ["Unique", "banding", "patterns", "only", "observed", "for", "ANT1", "(", "atp6", ")", ",", "C1839259#ent", "<e1>", "(", "atp6", ",", "orfH522", "and", "orfH708", ")", "and", "C3889721#ent", "<e2>", "(", "coxII", ")", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3889721", "name": "C3889721#ent", "pos": [21, 22]}}
{"token": ["Signal", "transduction", "PI3Kgamma", "to", "JNK", "can", "be", "suppressed", "by", "dominant", "negative", "mutants", "of", "Ras", ",", "C0812228#ent", "<e1>", ",", "and", "the", "C1955933#ent", "<e2>"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1955933", "name": "C1955933#ent", "pos": [20, 21]}}
{"token": ["Since", "FG", "and", "C2936904#ent", "<e1>", "many", "manifestations", "we", "considered", "C1417168#ent", "<e2>", "a", "candidate", "gene", "for", "FG", "syndrome"], "h": {"id": "C2936904", "name": "C2936904#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417168", "name": "C1417168#ent", "pos": [9, 10]}}
{"token": ["mRNA", "levels", "of", "mineralocorticoid", "receptors", "MRs", ")", "and", "glucocorticoid", "receptors", "C1412761#ent", "<e1>", ")", ",", "corticotropin-releasing", "hormone", "CRH", ")", "mRNA", "and", "C0041491#ent", "<e2>", "TH", ")", "mRNA", "were", "measured", "in", "brain", "sections", "with", "in", "situ", "hybridization"], "h": {"id": "C1412761", "name": "C1412761#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041491", "name": "C0041491#ent", "pos": [20, 21]}}
{"token": ["The", "pharmacokinetic", "properties", "of", "C0246631#ent", "<e1>", "may", "allow", "a", "rapid", "analgesic", "action", "C0030193#ent", "<e2>", "short", "lasting", "postoperative", "respiratory", "depression"], "h": {"id": "C0246631", "name": "C0246631#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}}
{"token": ["The", "structural", "dynamics", "loop", "8", "Sco1", "suggests", "it", "may", "be", "an", "interface", "for", "interactions", "with", "C1425328#ent", "<e1>", ",", "the", "Cu(I)", "donor", "and/or", "C1367485#ent", "<e2>", "."], "h": {"id": "C1425328", "name": "C1425328#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1367485", "name": "C1367485#ent", "pos": [22, 23]}}
{"token": ["Thirty", "six", "SLC", "patients", "have", "been", "treated", "with", "combination", "therapy", "ifosfamide", "2", ",", "C3889128#ent", "<e1>", "and", "D2", ",", "carboplatin", "300", "mg/m2", "C3889128#ent", "<e1>", "and", "C0039512#ent", "<e1>", "100", "mg/m2", "C3889128#ent", "<e1>", "to", "D3", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [24, 25]}}
{"token": ["This", "and", "the", "fact", "that", "the", "total", "amounts", "of", "C3889128#ent", "<e1>", "and", "D2", "proteins", "not", "affected", "by", "C0039512#ent", "<e2>", "suggest", "that", "the", "number", "of", "PSII", "centres", "within", "the", "membranes", "remained", "unchanged", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [17, 18]}}
{"token": ["Protection", "of", "the", "bone", "meal", "treated", "with", "%", "of", "C0072186#ent", "<e1>", "new", "contamination", "of", "C0036117#ent", "<e2>", "has", "proved", "to", "be", "independent", "of", "the", "rate", "of", "recontamination", "."], "h": {"id": "C0072186", "name": "C0072186#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [14, 15]}}
{"token": ["Elements", "of", "the", "model", "may", "be", "applicable", "to", "the", "C0072522#ent", "<e1>", "other", "herpesviruses", "and", "relevant", "to", "the", "immunobiology", "of", "C0019372#ent", "<e2>"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "whether", "these", "different", "genetic", "entities", "display", "different", "morphological", "phenotypes", "we", "compared", "sural", "nerve", "biopsies", "C1413535#ent", "<e1>", "patients", "due", "to", "C1419148#ent", "<e2>", "duplication", "with", "biopsies", "of", "CMTX1", "patients", "with", "proven", "Connexin32", "mutations", "."], "h": {"id": "C1413535", "name": "C1413535#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1419148", "name": "C1419148#ent", "pos": [21, 22]}}
{"token": ["In", "most", "cases", ",", "the", "disorder", "has", "been", "associated", "with", "partial", "duplication", "of", "human", "chromosome", "17", "(", "C1413535#ent", "<e1>", ")", ",", "causing", "1.5-fold", "overexpression", "of", "the", "peripheral", "myelin", "protein", "22", "kDa", "C1419148#ent", "<e2>", ")", "."], "h": {"id": "C1413535", "name": "C1413535#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419148", "name": "C1419148#ent", "pos": [31, 32]}}
{"token": ["The", "endogenous", "ngn3", "and", "C0256079#ent", "<e1>", "CBP", ")", "co-activator", "occupy", "the", "C1416457#ent", "<e2>", "promoter", ",", "resulting", "in", "hyper-acetylation", "of", "histone", "H3/H4", "chromatin", "a", "human", "neuroblastoma", "cell", "line", "IMR-32", "."], "h": {"id": "C0256079", "name": "C0256079#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416457", "name": "C1416457#ent", "pos": [11, 12]}}
{"token": ["C1420119#ent", "<e1>", "may", "participate", "in", "normal", "GABA", "neurosynthesis", "and", "limbic", "hyperexcitability", ",", "whereas", "C0014544#ent", "<e2>", "can", "result", "from", "a", "disruption", "of", "the", "interaction", "between", "C1420119#ent", "<e1>", "and", "GABA", "metabolism", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420119", "name": "C1420119#ent", "pos": [0, 1]}}
{"token": ["Amylase", "release", "by", "the", "cholinergic", "C2987634#ent", "<e1>", "carbachol", ",", "by", "the", "C3536829#ent", "<e2>", "isoproterenol", ",", "and", "by", "monensin", "was", "similar", "to", "responses", "obtained", "in", "mouse", "parotid", "fragments", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536829", "name": "C3536829#ent", "pos": [11, 12]}}
{"token": ["Conversely", ",", "a", "selective", "alpha", "2-adrenergic", "receptor", "C2987634#ent", "<e1>", "facilitated", "the", "cAMP", "response", "to", "a", "C3536829#ent", "<e2>", "affecting", "IP", "formation", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536829", "name": "C3536829#ent", "pos": [15, 16]}}
{"token": ["Modification", "of", "these", "substrates", "by", "limited", "proteolysis", "with", "C1413109#ent", "<e1>", "abolishes", "their", "ability", "to", "promote", "the", "conversion", "of", "C0072028#ent", "<e2>", "."], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0072028", "name": "C0072028#ent", "pos": [18, 19]}}
{"token": ["Injection", "of", "a", "C1510932#ent", "<e1>", "RU486", "or", "an", "inhibitor", "of", "3beta-hydroxysteroid", "C0030016#ent", "<e2>", "1h", "before", "hCG", "treatment", "inhibited", "hCG-induced", "Pcsk5", "mRNA", "levels", "."], "h": {"id": "C1510932", "name": "C1510932#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [11, 12]}}
{"token": ["Studies", "in", "vitro", "C0070342#ent", "<e1>", "by", "C0014442#ent", "<e2>", "homogenates", "of", "mouse", "brain", "HPLC", "techniques", "revealed", "that", "C0070342#ent", "<e1>", "bound", "to", "the", "membrane", "homogenate", "for", "an", "extended", "period", "of", "time", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0070342", "name": "C0070342#ent", "pos": [3, 4]}}
{"token": ["The", "effects", "of", "four", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitors", ",", "captopril", ",", "enalapril", ",", "C0072857#ent", "<e1>", "and", "alacepril", ",", "on", "the", "cough", "responses", "by", "citric", "acid", "C0006931#ent", "<e2>", "inhalation", "were", "studied", "in", "normal", "and", "bronchitic", "guinea-pigs"], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [26, 27]}}
{"token": ["C3160718#ent", "<e1>", "098059", ",", "but", "not", "SB", "203580", ",", "inhibited", "C0062773#ent", "<e2>", "HAT", ")", "activity", ",", "indicating", "chromatin", "modification"], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [10, 11]}}
{"token": ["C3160718#ent", "<e1>", "098059", ",", "but", "not", "SB", "203580", ",", "inhibited", "LPS-induced", "histone", "acetyltransferase", "C0062773#ent", "<e2>", ")", "activity", ",", "indicating", "chromatin", "modification"], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [13, 14]}}
{"token": ["Antisense", "inhibition", "of", "GADD45beta", "expression", "suppresses", "the", "TGF-beta-induced", "delayed", "C1705633#ent", "<e1>", "activation", ",", "whereas", "overexpression", "of", "GADD45beta", "activates", "the", "p38", "MAPK", "C1456388#ent", "<e2>", "."], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1456388", "name": "C1456388#ent", "pos": [21, 22]}}
{"token": ["In", "myocardial", "infarction", "patients", "with", "C0018801#ent", "<e1>", "nitroglycerin", "and", "C0037533#ent", "<e2>", "a", "favorable", "effect", "on", "systemic", "oxygen", "regimen", "and", "central", "hemodynamics"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [9, 10]}}
{"token": ["Risedronate", "(", "C0140610#ent", "<e1>", ",", "an", "orally", "administered", "C0012544#ent", "<e2>", "inhibits", "osteoclast-mediated", "resorption", "of", "bone", "and", "modulates", "bone", "metabolism", "women", "with", "postmenopausal", "osteoporosis"], "h": {"id": "C0140610", "name": "C0140610#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [8, 9]}}
{"token": ["C0023816#ent", "<e1>", "LPL", ")", "activity", "was", "enhanced", "by", "intravenous", "injection", "of", "C0235480#ent", "<e2>", "before", "intravenous", "injection", "of", "heparin", "when", "the", "C0235480#ent", "<e2>", "dose", "was", "low", "(", "0.2", "micrograms/kg", ")", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [11, 12]}}
{"token": ["C0016282#ent", "<e1>", "total", "fenamates", "(", "except", "C0359916#ent", "<e2>", "metabolites", ")", "were", "determined", "."], "h": {"id": "C0016282", "name": "C0016282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0359916", "name": "C0359916#ent", "pos": [6, 7]}}
{"token": ["The", "sudden", "interruption", "an", "intracortical", "instillation", "of", "exogenous", "C0242898#ent", "<e1>", "GABA", ")", "generates", "an", "C0085543#ent", "<e2>", "mammals", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [14, 15]}}
{"token": ["Aberrant", "activation", "of", "the", "C1335824#ent", "<e1>", "Shh", ")", "signaling", "pathway", "which", "normally", "stimulates", "proliferation", "of", "C1415311#ent", "<e2>", "GNP", ")", "during", "cerebellar", "development", "induces", "tumors", "in", "mice", "that", "closely", "mimic", "human", "medulloblastomas", "."], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415311", "name": "C1415311#ent", "pos": [15, 16]}}
{"token": ["Autonomic", "neuropathy", "a", "frequent", "feature", "of", "diabetic", "neuropathy", "the", "source", "of", "many", "significant", "problems", "including", "postural", "hypotension", "C0152020#ent", "<e1>", ",", "diarrhea", ",", "constipation", ",", "C0005697#ent", "<e2>", "and", "male", "impotence", "."], "h": {"id": "C0152020", "name": "C0152020#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [24, 25]}}
{"token": ["In", "eight", "dogs", ",", "C0001645#ent", "<e1>", "timolol", "(", "0.1", "mg/kg", ")", "had", "no", "effect", "the", "C2681537#ent", "<e2>", "determined", "with", "either", "method", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2681537", "name": "C2681537#ent", "pos": [15, 16]}}
{"token": ["Further", "RT-PCR", "analysis", "sequencing", "of", "the", "amplified", "products", "revealed", "a", "novel", "C3639980#ent", "<e1>", "fusion", "transcript", "in", "which", "nucleotide", "1216", "exon", "10", "of", "C1423601#ent", "<e2>", "was", "fused", "in-frame", "with", "nucleotide", "422", "exon", "6", "of", "SSX1", "."], "h": {"id": "C3639980", "name": "C3639980#ent", "pos": [11, 12]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1423601", "name": "C1423601#ent", "pos": [22, 23]}}
{"token": ["Accordingly", ",", "we", "propose", "that", "hypoketonemia", "is", "a", "critical", "factor", "in", "the", "C2984892#ent", "<e1>", "of", "fasting", "hypoglycemia", "in", "C3714796#ent", "<e2>"], "h": {"id": "C2984892", "name": "C2984892#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714796", "name": "C3714796#ent", "pos": [18, 19]}}
{"token": ["Despite", "the", "similarity", "of", "these", "two", "mutations", ",", "the", "alpha", "2", "mutant", "results", "in", "a", "more", "severe", "loss", "of", "C0544482#ent", "<e1>", "a", "more", "severe", "clinical", "C0472762#ent", "<e2>", "phenotype", "than", "the", "corresponding", "alpha", "1-globin", "gene", "mutation"], "h": {"id": "C0544482", "name": "C0544482#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0472762", "name": "C0472762#ent", "pos": [25, 26]}}
{"token": ["The", "dikaryon", "heterokaryotic", "for", "uvs-2", "(", "H-71", ")", "has", "the", "same", "sensitivity", "to", "formaldehyde-induced", "C1334877#ent", "<e1>", "mutation", "as", "H-12", ",", "indicating", "that", "uvs-2", "is", "C0017361#ent", "<e2>", "to", "uvs-2", "+", "."], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [24, 25]}}
{"token": ["This", "structural", "model", "be", "useful", "in", "the", "search", "for", "the", "physiological", "substrates", "of", "these", "C3541394#ent", "<e1>", "and", "in", "the", "design", "of", "more", "specific", "inhibitors", "of", "C1540042#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1540042", "name": "C1540042#ent", "pos": [25, 26]}}
{"token": ["This", "implies", "that", "alcohol", "extraction", "destroys", "an", "active", "component", "soy", ",", "C2712370#ent", "<e1>", "the", "structural", "integrity", "the", "C0677666#ent", "<e2>", "or", "disassociates", "a", "required", "isoflavone-soy", "protein", "complex"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0677666", "name": "C0677666#ent", "pos": [17, 18]}}
{"token": ["A", "number", "of", "quinolone", "antibacterial", "agents", "particularly", "enoxacin", ",", "pefloxacin", ",", "C0031953#ent", "<e1>", "ciprofloxacin", ",", "are", "known", "to", "decrease", "the", "clearance", "of", "C3536939#ent", "<e2>", "."], "h": {"id": "C0031953", "name": "C0031953#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3536939", "name": "C3536939#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "the", "link", "between", "C0019196#ent", "<e1>", "glucose", "intolerance", "we", "measured", "insulin", "sensitivity", "glucose", "effectiveness", "beta-cell", "secretion", "C1318485#ent", "<e2>", "HCV-infected", "patients", "with", "normal", "glucose", "tolerance", "to", "WHO", "criteria", "as", "assessed", "by", "oral", "glucose", "tolerance", "tests"], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1318485", "name": "C1318485#ent", "pos": [17, 18]}}
{"token": ["C1096903#ent", "<e1>", "be", "suspected", "in", "patients", "with", "unexplained", "psychomotor", "retardation", "associated", "with", "C0004134#ent", "<e2>", "and/or", "pyramidal", "symptoms", ",", "and", "MRI", "findings", "consistent", "with", "cerebral", "hypomyelination", "irrespective", "of", "the", "patient's", "ethnic", "origin"], "h": {"id": "C1096903", "name": "C1096903#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [12, 13]}}
{"token": ["Treatment", "of", "cultured", "cells", "C0142812#ent", "<e1>", "that", "is", "the", "C1512474#ent", "<e2>", "induces", "the", "histone", "hyperacetylation", "the", "expressions", "of", "various", "mammalian", "genes", "without", "affecting", "the", "level", "of", "protein", "synthesis"], "h": {"id": "C0142812", "name": "C0142812#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1512474", "name": "C1512474#ent", "pos": [9, 10]}}
{"token": ["C0142812#ent", "<e1>", "NaB", ")", ",", "a", "C1512474#ent", "<e2>", "has", "been", "shown", "to", "cause", "a", "G(1)", "cell", "cycle", "arrest", "inducing", "p21(WAF1/CIP1", ")", "in", "a", "p53-independent", "manner", "."], "h": {"id": "C0142812", "name": "C0142812#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512474", "name": "C1512474#ent", "pos": [6, 7]}}
{"token": ["Cytochrome", "b5", "(", "41", "%", ")", "to", "the", "PEG-Ficoll", "interphase", ",", "and", "C0027310#ent", "<e1>", "\"", "cytochromes", "P-420", "\"", "to", "the", "Ficoll", "and", "C0086140#ent", "<e2>"], "h": {"id": "C0027310", "name": "C0027310#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [22, 23]}}
{"token": ["Vascular", "reactivity", "heat", "and", "cold", "was", "studied", "in", "11", "normal", "subjects", "C0042373#ent", "<e1>", "in", "23", "patients", "with", "C0034735#ent", "<e2>", "etiologies", ":", "Raynaud's", "disease", "scleroderma", ",", "thoracic", "outlet", "syndrome", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0034735", "name": "C0034735#ent", "pos": [17, 18]}}
{"token": ["C0042171#ent", "<e1>", "an", "unusual", "manifestation", "of", "C0036202#ent", "<e2>", "is", "characterized", "by", "parotitis", ",", "uveitis", ",", "and", "facial", "nerve", "paralysis"], "h": {"id": "C0042171", "name": "C0042171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036202", "name": "C0036202#ent", "pos": [6, 7]}}
{"token": ["The", "oral", "administration", "N-acetylcysteine", "attenuated", "the", "ECS-related", "loss", "of", "C0919457#ent", "<e1>", ",", "whereas", "oltipraz", ",", "5,6-benzoflavone", ",", "phenethyl", "isothiocyanate", "and", "C0063491#ent", "<e2>", "and", "their", "combinations", "had", "no", "significant", "."], "h": {"id": "C0919457", "name": "C0919457#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0063491", "name": "C0063491#ent", "pos": [20, 21]}}
{"token": ["We", "studied", "differentiation", "induction", "of", "primary", "cultured", "bone", "marrow", "cells", "myelodysplastic", "syndrome", "C3273937#ent", "<e1>", ")", "patients", "by", "ara-C", "and", "C0733688#ent", "<e2>", "with", "or", "without", "addition", "of", "G-CSF", "."], "h": {"id": "C3273937", "name": "C3273937#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0733688", "name": "C0733688#ent", "pos": [19, 20]}}
{"token": ["The", "results", "suggest", "that", "the", "addition", "of", "a", "C3536709#ent", "<e1>", "to", "standard", "treatment", "lower", "mortality", "in", "C0039614#ent", "<e2>", ",", "although", "meticulous", "nursing", "care", "still", "the", "most", "important", "factor", "in", "treatment", "."], "h": {"id": "C3536709", "name": "C3536709#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039614", "name": "C0039614#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "indicate", "that", "a", "single", "dose", "cetirizine", "provides", "a", "more", "effective", "and", "long", "acting", "suppression", "on", "wheal", "and", "flare", "reactions", "in", "C0042109#ent", "<e1>", "when", "compared", "to", "acrivastine", "and", "C0065180#ent", "<e2>", "."], "h": {"id": "C0042109", "name": "C0042109#ent", "pos": [22, 23]}, "relation": "may_be_treated_by", "t": {"id": "C0065180", "name": "C0065180#ent", "pos": [29, 30]}}
{"token": ["We", "have", "investigated", "the", "role", "of", "C0850666#ent", "<e1>", "of", "other", "risk", "factors", "gastritis", "and", "C0869523#ent", "<e2>", "in", "residents", "of", "a", "high-risk", "area", "gastric", "cardia", "cancer"], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0869523", "name": "C0869523#ent", "pos": [14, 15]}}
{"token": ["A", "32-year-old", "man", "with", "C0024796#ent", "<e1>", "admitted", "to", "our", "hospital", "for", "detail", "examination", "of", "C0018802#ent", "<e2>"], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}}
{"token": ["The", "pelvic", "peritonitis", "with", "C0000833#ent", "<e1>", "periappendiceal", "abscesses", "complications", "of", "C1290884#ent", "<e2>"], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [10, 11]}}
{"token": ["In", "the", "present", "study", ",", "we", "demonstrated", "mRNA", "and", "cell", "surface", "expression", "of", "HIV-1", "receptors", "C1332714#ent", "<e1>", "and", "the", "chemokine", "receptors", "C1704797#ent", "<e2>", "and", "CXCR-4", "in", "fractionated", "cells", "multiple", "stages", "hematopoietic", "development", "."], "h": {"id": "C1332714", "name": "C1332714#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704797", "name": "C1704797#ent", "pos": [21, 22]}}
{"token": ["When", "rat", "C0013604#ent", "<e1>", "induced", "by", "the", "injection", "of", "C3539768#ent", "<e2>", "the", "peptide", "produced", "a", "significant", "inhibition", "(", "31", "%", ")", "at", "the", "top", "dose", "of", "20", "micrograms", "per", "paw", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [9, 10]}}
{"token": ["Cdc42", "homologous", "protein", "C1846989#ent", "<e1>", ")", "is", "a", "member", "of", "the", "Rho", "family", "small", "C0242853#ent", "<e2>", "and", "shares", "significant", "sequence", "and", "functional", "similarity", "with", "Cdc42", "."], "h": {"id": "C1846989", "name": "C1846989#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [14, 15]}}
{"token": ["The", "C0277565#ent", "<e1>", "been", "previously", "mapped", "by", "linkage", "analysis", "C0795803#ent", "<e2>", "the", "microsatellite", "marker", "."], "h": {"id": "C0277565", "name": "C0277565#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0795803", "name": "C0795803#ent", "pos": [9, 10]}}
{"token": ["FOXO", "and", "TOR", "also", "converge", "to", "regulate", "protein", "synthesis", "acting", "via", "C2984182#ent", "<e1>", "and", "Lk6", ",", "regulators", "of", "the", "translation", "factor", "C1414351#ent", "<e2>", "."], "h": {"id": "C2984182", "name": "C2984182#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414351", "name": "C1414351#ent", "pos": [21, 22]}}
{"token": ["To", "study", "the", "role", "of", "the", "autosomal", "candidate", "gene", "C3891075#ent", "<e1>", "(", "Deleted", "in", "AZoospermia", "Like", "Autosome", ")", "in", "male", "C0729353#ent", "<e2>", "."], "h": {"id": "C3891075", "name": "C3891075#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0729353", "name": "C0729353#ent", "pos": [20, 21]}}
{"token": ["Herein", "we", "report", "a", "child", "with", "C0025469#ent", "<e1>", "presented", "with", "an", "acute", "abdomen", "misdiagnosed", "as", "C0003615#ent", "<e2>"], "h": {"id": "C0025469", "name": "C0025469#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003615", "name": "C0003615#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "central", "neurons", "directly", "to", "massive", "infiltration", "of", "lymphocytes", "and", "macrophages", "after", "the", "breakdown", "of", "the", "blood-brain", "barrier", "C1801950#ent", "<e1>", ")", ",", "by", "producing", "TNF", "alpha", "C1333196#ent", "<e2>", "."], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [29, 30]}}
{"token": ["Analysis", "of", "molecular", "networks", "canonical", "pathways", "associated", "with", "differentially", "expressed", "genes", "suggest", "that", "HIV-1", "causes", "C1801950#ent", "<e1>", "impairment", "by", "mechanisms", "involving", "inflammation", ",", "C1333196#ent", "<e2>", ",", "and", "IFN", "signaling", "HBMEC", "."], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [23, 24]}}
{"token": ["The", "findings", "that", "chronic", "morphine", "treatment", "alters", "both", "blood-brain", "barrier", "C1801950#ent", "<e1>", ")", "function", "and", "C1333196#ent", "<e2>", "production", "raises", "the", "possibility", "that", "morphine", "can", "also", "modulate", "cytokine", "transport", "the", "C1801950#ent", "<e1>", "."], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [15, 16]}}
{"token": ["The", "oncogene", "Ras", "involved", "in", "the", "regulation", "of", "C1332805#ent", "<e1>", ",", "as", "high", "expression", "level", "of", "the", "constitutively", "active", "form", "C0034678#ent", "<e2>", "in", "normal", "or", "AD", "fibroblasts", "induces", "C1332805#ent", "<e1>", "down-regulation", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1332805", "name": "C1332805#ent", "pos": [8, 9]}}
{"token": ["In", "malaria", ",", "C0376261#ent", "<e1>", "and", "ketones", ",", "but", "not", "C0036075#ent", "<e2>", ",", "are", "associated", "with", "acidosis", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036075", "name": "C0036075#ent", "pos": [10, 11]}}
{"token": ["Therefore", ",", "C0034069#ent", "<e1>", "should", "be", "considered", "a", "spectrum", "of", "C0400966#ent", "<e2>", "that", "may", "prelude", "NASH", "in", "morbid", "obesity"], "h": {"id": "C0034069", "name": "C0034069#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0400966", "name": "C0400966#ent", "pos": [10, 11]}}
{"token": ["From", "our", "data", ",", "the", "clinical", "criteria", "consideration", "of", "an", "underlying", "C1414083#ent", "<e1>", "in", "isolated", "female", "cases", "of", "myopathy", "are", "C0010287#ent", "<e2>", "levels", "greater", "than", "1,000", "IU/l", "and", "myopathic", "histopathology"], "h": {"id": "C1414083", "name": "C1414083#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010287", "name": "C0010287#ent", "pos": [20, 21]}}
{"token": ["C0018213#ent", "<e1>", "'", "patient", "immunoglobulins", "IgG", ")", "are", "known", "to", "activate", "C1382029#ent", "<e2>"], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [11, 12]}}
{"token": ["We", "report", "the", "case", "of", "a", "16-year-old", "boy", "who", "presented", "with", "C0011848#ent", "<e1>", "six", "months", "'", "standing", ",", "associated", "with", "visual", "loss", "C1282916#ent", "<e2>"], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1282916", "name": "C1282916#ent", "pos": [22, 23]}}
{"token": ["Concurrently", ",", "we", "review", "a", "rich", "rodent", "literature", "concerned", "with", "A", ",", "C3814032#ent", "<e1>", ",", "NE", ",", "and", "DA", "receptors", "the", "C2986870#ent", "<e2>", "and", "related", "structures", "along", "with", "other", "monoamine", "parameters", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2986870", "name": "C2986870#ent", "pos": [21, 22]}}
{"token": ["A", "search", "for", "a", "C0398623#ent", "<e1>", "a", "nonfamilial", "C0242666#ent", "<e2>"], "h": {"id": "C0398623", "name": "C0398623#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0242666", "name": "C0242666#ent", "pos": [8, 9]}}
{"token": ["C0398623#ent", "<e1>", "mainly", "defects", "of", "the", "protein", "C", "pathway", "resistance", "to", "activated", "protein", "C", "protein", "C", "C0242666#ent", "<e2>"], "h": {"id": "C0398623", "name": "C0398623#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0242666", "name": "C0242666#ent", "pos": [16, 17]}}
{"token": ["C0016860#ent", "<e1>", "(", "30", "mg/kg", ")", "was", "given", "orally", "to", "the", "C1569495#ent", "<e2>", "(", "an", "alpha", "1-blocker)-", "or", "vehicle-treated", "rats", "at", "12", "AM", "or", "12", "PM", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1569495", "name": "C1569495#ent", "pos": [11, 12]}}
{"token": ["Enzyme", "(", "C0937932#ent", "<e1>", "or", "invertase", ")", "was", "entrap-immobilized", "in", "C0225326#ent", "<e2>", "cellulose", "acetate-TiO2", "by", "using", "a", "gel", "formation", "cellulose", "acetate", "titanium", "iso-propoxide", "."], "h": {"id": "C0937932", "name": "C0937932#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [10, 11]}}
{"token": ["Recent", "literature", "discussing", "C0015411#ent", "<e1>", "the", "following", "systemic", "infectious", "diseases", "reviewed", ":", "C0041296#ent", "<e2>", ",", "Lyme", "borreliosis", "cat", "scratch", "disease", "toxocariasis", ",", "congenital", "toxoplasmosis", "and", "invasive", "aspergillosis"], "h": {"id": "C0015411", "name": "C0015411#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [12, 13]}}
{"token": ["Anterior", "granulomatous", "non-granulomatous", "uveitis", "chorioretinitis", "and", "retinal", "vasculitis", "common", "C0015411#ent", "<e1>", "while", "tuberculoma", ",", "scleritis", ",", "keratitis", "and", "C0041296#ent", "<e2>", "rare", "."], "h": {"id": "C0015411", "name": "C0015411#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [18, 19]}}
{"token": ["Autosomal", "recessive", "hypercholesterolemia", "C1863512#ent", "<e1>", ")", "is", "a", "rare", "C0242339#ent", "<e2>", "characterized", "by", "markedly", "elevated", "plasma", "LDL", "levels", ",", "xanthomatosis", ",", "and", "premature", "coronary", "artery", "disease"], "h": {"id": "C1863512", "name": "C1863512#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242339", "name": "C0242339#ent", "pos": [9, 10]}}
{"token": ["Acetazolamide", "improved", "C1414426#ent", "<e1>", ",", "O2", "and", "reduced", "pH", "and", "C1414426#ent", "<e1>", ",", "C1537986#ent", "<e1>", "."], "h": {"id": "C1414426", "name": "C1414426#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1537986", "name": "C1537986#ent", "pos": [13, 14]}}
{"token": ["The", "hemodynamic", ",", "hormonal", ",", "and", "metabolic", "effects", "chronic", "neutral", "endopeptidase", "NEP", ")", "24.11", "inhibition", "and", "C0016860#ent", "<e1>", "were", "compared", "in", "the", "pacing", "model", "C0018801#ent", "<e2>", "HF", ")", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [24, 25]}}
{"token": ["Commonly", "used", "C0003205#ent", "<e1>", "such", "as", "C0008196#ent", "<e2>", "are", "not", "selective", "enough", "and", "causes", "overgrowth", "of", "some", "viridans-streptococci", "."], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008196", "name": "C0008196#ent", "pos": [6, 7]}}
{"token": ["Excretion", "rates", "for", "C3541396#ent", "<e1>", ",", "iron", "and", "C1445745#ent", "<e2>", "were", "lower", "in", "TN", "groups", "than", "in", "the", "corresponding", "HS", "groups", "."], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1445745", "name": "C1445745#ent", "pos": [8, 9]}}
{"token": ["Two", "experimental", "models", "liver", "diseases", "rats", "were", "used", ":", "C0005398#ent", "<e1>", "by", "bile", "duct", "ligation", "and", "hepatic", "necrosis", "induced", "by", "C0524928#ent", "<e2>", "tetrachloride", "administration", "."], "h": {"id": "C0005398", "name": "C0005398#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [20, 21]}}
{"token": ["The", "human", "liver", "microsomal", "CYP1A2", "inactivation", "kinetics", "of", "C0073096#ent", "<e1>", ",", "oltipraz", ",", "furafylline", ",", "and", "C0020223#ent", "<e2>", "(", "Fig.", "2", ")", "were", "evaluated", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [16, 17]}}
{"token": ["Elevated", "levels", "of", "the", "C0032144#ent", "<e1>", "observed", "in", "C3890176#ent", "<e2>", "lesions", "."], "h": {"id": "C0032144", "name": "C0032144#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890176", "name": "C3890176#ent", "pos": [8, 9]}}
{"token": ["Protein", "anabolism", "be", "induced", "in", "C0022661#ent", "<e1>", "patients", "by", "repletion", "of", "C3539947#ent", "<e2>", "and", "perhaps", "treatment", "with", "recombinant", "human", "insulin-like", "growth", "factor"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [11, 12]}}
{"token": ["C0022661#ent", "<e1>", "associated", "with", "mild", "abnormalities", "serum", "concentrations", "of", "C3539947#ent", "<e2>"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [9, 10]}}
{"token": ["Sixteen", "patients", "with", "C0022661#ent", "<e1>", "maintenance", "hemodialysis", "were", "studied", "before", "and", "during", "oral", "treatment", "essential", "C3539947#ent", "<e2>"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [15, 16]}}
{"token": ["We", "tested", "whether", "C0027697#ent", "<e1>", "trigger", "excretion", "of", "C4082486#ent", "<e2>", "infectivity", "into", "urine", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4082486", "name": "C4082486#ent", "pos": [8, 9]}}
{"token": ["MI", "resulted", "in", "C0018802#ent", "<e1>", "that", "was", "partially", "reversed", "by", "C0072857#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0072857", "name": "C0072857#ent", "pos": [10, 11]}}
{"token": ["We", "examined", "in", "mice", "the", "effect", "of", "chronic", "C0012010#ent", "<e1>", "treatment", "on", "the", "sensitivity", "to", "C0022180#ent", "<e2>", ",", "and", "that", "of", "repeated", "C0022180#ent", "<e2>", "exposure", "on", "the", "sensitivity", "to", "C0012010#ent", "<e1>", "."], "h": {"id": "C0022180", "name": "C0022180#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [8, 9]}}
{"token": ["HLA-DR4", "and", "keratoconjunctivitis", "sicca", "C1527336#ent", "<e1>", "are", "associated", "with", "abnormal", "pulmonary", "function", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["This", "FGF2", "dose", "also", "stimulated", "Gdnf", "mRNA", "at", "48", "h.", "FGF2", "effects", "on", "Etv5", "and", "Gdnf", "mRNA", "were", "partially", "mediated", "through", "C0752312#ent", "<e1>", "MAPK", ")", "and", "C2936824#ent", "<e2>", "cascades", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [26, 27]}}
{"token": ["This", "induction", "depends", "on", "the", "activation", "of", "C0752312#ent", "<e1>", "MAP", ")", "kinase", ",", "and", "it", "is", "C2936824#ent", "<e2>", "as", "demonstrated", "with", "specific", "inhibitors", "for", "both", "pathways", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [16, 17]}}
{"token": ["The", "involvement", "of", "microsomal", "enzymes", "in", "C0003949#ent", "<e1>", "was", "indicated", "by", "alterations", "in", "glucose-6-phosphatase", "and", "C0268487#ent", "<e2>", "aniline", "hydroxylase"], "h": {"id": "C0003949", "name": "C0003949#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [15, 16]}}
{"token": ["One", "group", "of", "neurodegenerative", "dementias", "as", "FTDP-17", "(", "C0236642#ent", "<e1>", "Parkinsonism", "linked", "to", "chromosome", "17", "is", "directly", "linked", "C1516876#ent", "<e2>", "to", "mutations", "in", "the", "tau", "gene", "demonstrating", "that", "Tau", "misfunction", "can", "cause", "neuronal", "cell", "death", "dementia", "."], "h": {"id": "C0236642", "name": "C0236642#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [18, 19]}}
{"token": ["C1417081#ent", "<e1>", "which", "contained", "both", "tryptase", "and", "chymase", "(", "the", "C3811697#ent", "<e2>", "phenotype", ")", "represented", "approximately", "80", "-", "95", "per", "cent", "of", "all", "C1417081#ent", "<e1>", "."], "h": {"id": "C1417081", "name": "C1417081#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3811697", "name": "C3811697#ent", "pos": [10, 11]}}
{"token": ["In", "bowel", "mucosa", "%", "of", "C1417081#ent", "<e1>", "were", "MCT", ",", "35", "%", "were", "C3811697#ent", "<e2>", "and", "7", "%", "MCC", ",", "whereas", "in", "bowel", "submucosa", "%", "of", "C1417081#ent", "<e1>", "were", "C3811697#ent", "<e2>", "and", "17", "%", "MCC", "."], "h": {"id": "C1417081", "name": "C1417081#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811697", "name": "C3811697#ent", "pos": [13, 14]}}
{"token": ["C0033681#ent", "<e1>", "by", "fusion", "of", "the", "C1426030#ent", "<e2>", "and", "PDGFRA", "genes", ",", "which", "is", "characteristic", "of", "hypereosinophilic", "syndrome", "HES", ")", ",", "was", "detected", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1426030", "name": "C1426030#ent", "pos": [6, 7]}}
{"token": ["Compared", "to", "controls", ",", "patients", "with", "chronic", "hepatitis", "C", "significantly", "lower", "OROSO", "and", "C1826658#ent", "<e1>", ",", "and", "higher", "C1412296#ent", "<e2>", "levels", "."], "h": {"id": "C1826658", "name": "C1826658#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412296", "name": "C1412296#ent", "pos": [18, 19]}}
{"token": ["In", "conclusion", ",", "serum", "Hsp70", "and", "C1826658#ent", "<e1>", "concentrations", "are", "increased", ",", "whereas", "serum", "C1412296#ent", "<e2>", "concentration", "is", "decreased", ",", "in", "HELLP", "syndrome", "."], "h": {"id": "C1826658", "name": "C1826658#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412296", "name": "C1412296#ent", "pos": [14, 15]}}
{"token": ["The", "major", "products", "of", "ozonation", "were", "glycolaldehyde", ",", "C0022956#ent", "<e1>", ",", "formaldehyde", ",", "acetaldehyde", ",", "and", "C0981805#ent", "<e2>", ",", "formic", ",", "pyruvic", ",", "oxalic", "and", "glyoxalic", "acids"], "h": {"id": "C0022956", "name": "C0022956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0981805", "name": "C0981805#ent", "pos": [16, 17]}}
{"token": ["Monochemotherapy", "with", "C0010927#ent", "<e1>", ",", "temozolomide", ",", "fotemustine", "and", "C0042682#ent", "<e2>", "or", "its", "combinations", "with", "interferon-alpha", "are", "currently", "preferred", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042682", "name": "C0042682#ent", "pos": [9, 10]}}
{"token": ["The", "disorder", "with", "C1510471#ent", "<e1>", "confused", "with", "C3469521#ent", "<e2>", ",", "is", "currently", "known", "as", "linked", "to", "chromosome", "8q"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3469521", "name": "C3469521#ent", "pos": [7, 8]}}
{"token": ["However", ",", "the", "association", "of", "C0285558#ent", "<e1>", "with", "integrin-linked", "kinase", "ILK", ")", ",", "a", "C0031727#ent", "<e2>", "that", "potentially", "phosphorylates", "C0285558#ent", "<e1>", "at", "Ser473", ",", "and", "ILK", "abundance", "were", "similar", "in", "both", "age", "groups"], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}}
{"token": ["In", "order", "to", "assess", "the", "role", "of", "BER", "in", "protecting", "parasites", "against", "DNA", "damage", "we", "have", "C3889446#ent", "<e1>", "one", "enzyme", "of", "the", "pathway", ",", "C0950398#ent", "<e2>", "in", "Leishmania", "major"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0950398", "name": "C0950398#ent", "pos": [24, 25]}}
{"token": ["In", "conclusion", ",", "the", "present", "study", "suggests", "that", "C0054222#ent", "<e1>", "is", "safer", "than", "C1569495#ent", "<e2>", "for", "long-term", "treatment", "in", "view", "of", "electrophysiological", "effect"], "h": {"id": "C0054222", "name": "C0054222#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1569495", "name": "C1569495#ent", "pos": [13, 14]}}
{"token": ["External", "application", "of", "C1423502#ent", "<e1>", "augments", "the", "number", "of", "APs", "evoked", "by", "a", "C0027867#ent", "<e2>", "current", "ramp", "."], "h": {"id": "C1423502", "name": "C1423502#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "C0022252#ent", "<e1>", "increases", "the", "tendency", "towards", "C0017168#ent", "<e2>", "in", "CD-2", "patients", ",", "but", "not", "in", "healthy", "volunteers", "CD-1", "patients", "."], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [10, 11]}}
{"token": ["Other", "isoforms", "of", "C1431671#ent", "<e1>", "in", "humans", "and", "mice", "are", "known", "as", "hematopoietic", "progenitor", "kinase", "(HPK)/germinal", "center", "kinase", "(GCK)-like", "kinase", "C1367671#ent", "<e2>", "respectively", "."], "h": {"id": "C1431671", "name": "C1431671#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1367671", "name": "C1367671#ent", "pos": [20, 21]}}
{"token": ["Using", "C0034283#ent", "<e1>", "and", "trisulfapyrimidine", "in", "treating", "C0031669#ent", "<e2>", "patients", ",", "showed", "subsidence", "of", "skin", "lesions", "five", "patients", "with", "toxoplasmosis", "within", "two", "months", "from", "the", "beginning", "of", "therapy", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [7, 8]}}
{"token": ["C0268164#ent", "<e1>", "initially", "manifest", "as", "urolithiasis", ",", "C0035078#ent", "<e2>", "or", "symptoms", "of", "systemic", "oxalosis"], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [7, 8]}}
{"token": ["C0268164#ent", "<e1>", "characterized", "by", "severe", "urolithiasis", ",", "nephrocalcinosis", ",", "and", "C0035078#ent", "<e2>"], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [10, 11]}}
{"token": ["C0015840#ent", "<e1>", "attenuated", "this", "increase", "in", "regenerating", "C1416870#ent", "<e2>", "muscles", "but", "not", "soleus", "muscles"], "h": {"id": "C0015840", "name": "C0015840#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416870", "name": "C1416870#ent", "pos": [7, 8]}}
{"token": ["He", "was", "in", "C0476273#ent", "<e1>", "required", "intubation", "and", "ventilatory", "support", "to", "progressive", "C0427055#ent", "<e2>", "of", "the", "respiratory", "muscles"], "h": {"id": "C0476273", "name": "C0476273#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "the", "precise", "localisation", "of", "TRYX", ",", "C0960371#ent", "<e1>", "and", "C1415382#ent", "<e2>", "in", "the", "parasite", ",", "polyclonal", "antibodies", "purified", "recombinant", "TRYX", "and", "C0960371#ent", "<e1>", "and", "monoclonal", "antibody", "C1415382#ent", "<e2>", "were", "generated", "in", "mice", "."], "h": {"id": "C1415382", "name": "C1415382#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "the", "hemodynamic", "consequences", "of", "the", "coadministration", "of", "a", "continuous", "rate", "infusion", "CRI", ")", "of", "C0125656#ent", "<e1>", "with", "a", "C0015846#ent", "<e2>", "bolus", "in", "dogs", "."], "h": {"id": "C0125656", "name": "C0125656#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0015846", "name": "C0015846#ent", "pos": [20, 21]}}
{"token": ["Isobolographic", "analysis", "revealed", "that", "the", "effect", "of", "C0125656#ent", "<e1>", "combined", "with", "C0015846#ent", "<e2>", ",", "morphine", ",", "or", "meperidine", "was", "additive", "after", "iv", "administration", "."], "h": {"id": "C0125656", "name": "C0125656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015846", "name": "C0015846#ent", "pos": [11, 12]}}
{"token": ["C0020500#ent", "<e1>", "an", "important", "biochemical", "diagnostic", "hallmark", "for", "C0268164#ent", "<e2>", "PH1", ")", "."], "h": {"id": "C0020500", "name": "C0020500#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [8, 9]}}
{"token": ["Marked", "C0020500#ent", "<e1>", "results", "in", "urolithiasis", ",", "renal", "failure", "and", "C0268164#ent", "<e2>"], "h": {"id": "C0020500", "name": "C0020500#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "show", "that", "odor", "responses", "of", "the", "output", "cells", "the", "C1416825#ent", "<e1>", ",", "mitral", "cells", "change", "transiently", "during", "a", "go-no-go", "odor", "discrimination", "C0310298#ent", "<e2>", "."], "h": {"id": "C1416825", "name": "C1416825#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [23, 24]}}
{"token": ["C1416825#ent", "<e1>", "latencies", "and", "C0310298#ent", "<e2>", "performance", "did", "not", "differ", "between", "patients", "and", "control", "subjects"], "h": {"id": "C1416825", "name": "C1416825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [4, 5]}}
{"token": ["A", "common", "feature", "of", "both", "C0002895#ent", "<e1>", "thalassemia", "is", "intravascular", "hemolysis", "C0581384#ent", "<e2>"], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0581384", "name": "C0581384#ent", "pos": [11, 12]}}
{"token": ["When", "these", "conditions", "were", "excluded", ",", "C3711381#ent", "<e1>", "indicated", "the", "diagnosis", "of", "subacute", "sclerosing", "panencephalitis", "other", "C0014038#ent", "<e2>", "."], "h": {"id": "C3711381", "name": "C3711381#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [16, 17]}}
{"token": ["We", "show", "that", "C1421565#ent", "<e1>", "disrupts", "the", "interaction", "between", "C1705526#ent", "<e2>", "and", "the", "coactivator", "p300", "and", "that", "expression", "of", "C1421565#ent", "<e1>", "blocks", "p300-dependent", "acetylation", "and", "stabilization", "of", "C1705526#ent", "<e2>", "."], "h": {"id": "C1421565", "name": "C1421565#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [9, 10]}}
{"token": ["Overexpression", "of", "C1421565#ent", "<e1>", "reverses", "the", "repressive", "effect", "of", "C1705526#ent", "<e2>", ",", "suggesting", "a", "functional", "antagonism", "between", "C1705526#ent", "<e2>", "and", "C1421565#ent", "<e1>", "."], "h": {"id": "C1421565", "name": "C1421565#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [9, 10]}}
{"token": ["Fury", "et", "al.", "discuss", "how", "the", "presence", "or", "absence", "of", "alternatively", "spliced", "regions", "in", "the", "C3537389#ent", "<e1>", "act", "as", "a", "molecular", "switch", "which", "different", "C0031727#ent", "<e2>", "activate", "the", "BK", "channel"], "h": {"id": "C3537389", "name": "C3537389#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [24, 25]}}
{"token": ["C1334505#ent", "<e1>", "MGMT", ")", "is", "a", "DNA", "repair", "C0027203#ent", "<e2>", "which", "reduces", "the", "cytocidal", "effect", "of", "nitrosourea", "."], "h": {"id": "C1334505", "name": "C1334505#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["Epigenetic", "silencing", "the", "C1334505#ent", "<e1>", "encoding", "a", "DNA", "repair", "C0027203#ent", "<e2>", "was", "recently", "found", "to", "be", "of", "predictive", "value", "a", "randomized", "clinical", "trial", "newly", "diagnosed", "glioblastoma", "testing", "addition", "of", "the", "alkylating", "agent", "temozolomide", "to", "standard", "radiotherapy"], "h": {"id": "C1334505", "name": "C1334505#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["The", "ADH1", "and", "C1334468#ent", "<e1>", "the", "major", "C0001942#ent", "<e2>", "S.", "cerevisiae"], "h": {"id": "C1334468", "name": "C1334468#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [7, 8]}}
{"token": ["C1161352#ent", "<e1>", "blocked", "the", "interactions", "of", "the", "C1825450#ent", "<e2>", "with", "the", "muscarinic", "cholinergic", "receptors", "the", "pacemaker", "cells"], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1825450", "name": "C1825450#ent", "pos": [7, 8]}}
{"token": ["These", "regional", "differences", "expression", "were", "not", "seen", "with", "the", "control", "gene", "C1384510#ent", "<e1>", "or", "with", "the", "protooncogenes", "c-myc", "C0079419#ent", "<e2>", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079419", "name": "C0079419#ent", "pos": [18, 19]}}
{"token": ["Peptides", "SPwt", "and", "C1422837#ent", "<e1>", "but", "not", "SP-3", "or", "C1437927#ent", "<e2>", "were", "able", "to", "promote", "lipid", "mixing", "as", "assessed", "by", "fluorescence", "energy", "transfer", "assay", "dye", "leakage", "a", "vesicle", "leakage", "assay", "."], "h": {"id": "C1422837", "name": "C1422837#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1437927", "name": "C1437927#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "C0040979#ent", "<e1>", "could", "antagonise", "the", "effect", "of", "raised", "C2936886#ent", "<e2>", "concentration", "of", "superfusate", ",", "which", "decreases", "h", "max", "and", "shortens", "t2", "of", "the", "RP", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [10, 11]}}
{"token": ["We", "analyzed", "98", "Japanese", "families", "with", "C2936739#ent", "<e1>", ",", "for", "whom", "CAG", "repeat", "of", "the", "SCA1", ",", "C0752121#ent", "<e2>", ",", "Machado-Joseph", "disease/SCA3", "and", "dentatorubral-pallidoluysian", "atrophy", "genes", "excluded", ",", "and", "5", "apparently", "sporadic", "cases", "of", "cortical", "cerebellar", "atrophy"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [17, 18]}}
{"token": ["Six", "different", "genes", "causing", "C2936739#ent", "<e1>", "SCA", "are", "mapped", ":", "SCA1", ",", "C0752121#ent", "<e2>", ",", "Machado-Joseph", "disease", ",", "SCA4", ",", "SCA5", ",", "and", "dentatorubropallidoluysian", "atrophy", "DRPLA", ")", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [12, 13]}}
{"token": ["Mean", "age", "onset", "in", "the", "SCA6", "patients", "is", "52", "years", ",", "which", "is", "much", "later", "than", "those", "reported", "for", "other", "C2936739#ent", "<e1>", "ataxias", "including", "SCA1", ",", "C0752121#ent", "<e2>", ",", "Machado-Joseph", "disease", "and", "dentatorubral-pallidoluysian", "atrophy"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [26, 27]}}
{"token": ["C1824309#ent", "<e1>", "inhibited", "the", "activity", "of", "carboxymethyl", "cellulase", "Avicelase", ",", "whereas", "C1417500#ent", "<e2>", "+", "stimulated", "it", "."], "h": {"id": "C1824309", "name": "C1824309#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [11, 12]}}
{"token": ["It", "is", "shown", "that", "TFIIIC-dependent", "assembly", "of", "TFIIIB", "on", "the", "C1540007#ent", "<e1>", "promoter", "is", "specifically", "sensitive", "to", "this", "C1705151#ent", "<e2>", "deletion", ",", "leading", "to", "gene-specifically", "defective", "single-round", "and", "multiple-round", "transcription", "."], "h": {"id": "C1540007", "name": "C1540007#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705151", "name": "C1705151#ent", "pos": [18, 19]}}
{"token": ["Since", "C0012582#ent", "<e1>", "also", "inhibits", "cyclic", "guanosine", "monophosphate", "GMP", ")", "phosphodiesterase", "(", "C0031640#ent", "<e2>", ")", ",", "we", "used", "platelet", "rich", "plasma", "PRP", ")", "to", "study", "its", "interaction", "with", "authentic", "and", "endothelium-derived", "nitric", "oxide", "NO", ")", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [12, 13]}}
{"token": ["This", "shows", "that", "C0012582#ent", "<e1>", "is", "not", "selective", "for", "cGMP", "over", "cAMP", "C0031640#ent", "<e2>", "as", "previously", "believed", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [12, 13]}}
{"token": ["Caffeine", ",", "1-methyl-3-isobutylxanthine", ",", "papaverine", "and", "C0012582#ent", "<e1>", "were", "effective", "inhibitors", "of", "C0031640#ent", "<e2>", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [12, 13]}}
{"token": ["The", "modulation", "of", "C1708420#ent", "<e1>", "and", "beta2", "expression", "by", "C1412220#ent", "<e2>", "-", "11", "stimulation", "and", "TGF-beta", "is", "mainly", "involved", "in", "CD4", "+", "population", "."], "h": {"id": "C1708420", "name": "C1708420#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412220", "name": "C1412220#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "C1421478#ent", "<e1>", "protein", "family", "verprolin-homologous", "protein", "reorganization", "of", "actin", ",", "downstream", "of", "C0812228#ent", "<e2>", "plays", "an", "important", "role", "in", "normal", "development", "cadherin-dependent", "cell-cell", "adhesions", "in", "MDCK", "cells"], "h": {"id": "C1421478", "name": "C1421478#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [16, 17]}}
{"token": ["This", "compound", "represented", "the", "sole", "constituent", "of", "the", "bacterial", "extract", "was", "accepted", "as", "a", "C0242209#ent", "<e1>", "donor", "by", "C0030897#ent", "<e2>", "II", "in", "vitro"], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030897", "name": "C0030897#ent", "pos": [18, 19]}}
{"token": ["These", "data", "support", "the", "theory", "that", "clinical", "isolates", "causing", "C0033581#ent", "<e1>", "are", "more", "virulent", "than", "those", "producing", "C0600041#ent", "<e2>", "or", "pyelonephritis", "in", "women", "."], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0600041", "name": "C0600041#ent", "pos": [17, 18]}}
{"token": ["In", "cardiac", "myocytes", "Pak1", "activation", "leads", "to", "dephosphorylation", "of", "cTnI", "and", "C0164786#ent", "<e1>", "through", "upregulation", "of", "C1704708#ent", "<e2>", "(", "PP2A", ")", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [16, 17]}}
{"token": ["C1367721#ent", "<e1>", "but", "not", "basic", "fibroblast", "growth", "factor", "platelet-derived", "growth", "factor", ",", "which", "activates", "a", "C1334202#ent", "<e2>", "caused", "a", "small", "increase", "in", "rPGSi", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334202", "name": "C1334202#ent", "pos": [15, 16]}}
{"token": ["Regular", "exercise", "to", "decrease", "the", "incidence", "of", "a", "wide", "range", "of", "ROS-associated", "diseases", ",", "including", "heart", "disease", "C0011860#ent", "<e1>", "rheumatic", "arthritis", "Alzheimer", "and", "C0030567#ent", "<e2>", "and", "certain", "cancers", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [23, 24]}}
{"token": ["The", "C0031306#ent", "<e1>", "macrophages", "as", "well", "as", "the", "C0872913#ent", "<e2>", "and", "B-cell", "functions", "also", "increased", "."], "h": {"id": "C0031306", "name": "C0031306#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0872913", "name": "C0872913#ent", "pos": [8, 9]}}
{"token": ["The", "report", "deals", "with", "a", "female", "patient", "presenting", "myasthenia", "gravis", "8-year", "duration", ",", "maintained", "on", "continuous", "C0754188#ent", "<e1>", ",", "repeatedly", "cannulated", "central", "veins", ",", "and", "immunosuppressive", "therapy", "C3540725#ent", "<e2>", "--", "Imuran", "and", "Sandimmun", "."], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [27, 28]}}
{"token": ["Thus", ",", "the", "results", "of", "this", "study", "strongly", "indicate", "that", "etodolac", "is", "more", "effective", "and", "produces", "fewer", "side-effects", "than", "C0021246#ent", "<e1>", "in", "the", "treatment", "of", "patients", "with", "C0029408#ent", "<e2>", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [27, 28]}}
{"token": ["Ellagic", "acid", "C0034150#ent", "<e1>", ",", "quercetin", "and", "C0014963#ent", "<e2>", "inhibited", "GR", "activity", ";", "S-hexylglutathione", "and", "S-octylglutathione", "had", "no", "effect", "on", "GR", "and", "GSH-Px", "activities", "."], "h": {"id": "C0034150", "name": "C0034150#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014963", "name": "C0014963#ent", "pos": [7, 8]}}
{"token": ["Applicators", "'", "peak", "C0044091#ent", "<e1>", "levels", "occurred", "the", "day", "after", "the", "application", "(", "geometric", "mean", "C1418829#ent", "<e2>", ")", "=", "19.0", "microg/l", ")", "."], "h": {"id": "C0044091", "name": "C0044091#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418829", "name": "C1418829#ent", "pos": [15, 16]}}
{"token": ["Incubation", "of", "horse", "liver", "aldehyde", "dehydrogenase", "aldehyde", ":", "C1537381#ent", "<e1>", "EC", "1.2.1.3", "with", "2-hydroxyethyl", "disulfide", "mixed-disulfides", "between", "protein", "sulfhydryl", "and", "C0010648#ent", "<e2>", "."], "h": {"id": "C1537381", "name": "C1537381#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010648", "name": "C0010648#ent", "pos": [20, 21]}}
{"token": ["A", "recent", "report", "described", "serum", "anti-GQ1b", "ganglioside", "antibodies", "C0393799#ent", "<e1>", "MFS", ")", ",", "a", "clinical", "variant", "Guillain-Barr\u00e9", "syndrome", "C4083008#ent", "<e2>", ")", "."], "h": {"id": "C0393799", "name": "C0393799#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4083008", "name": "C4083008#ent", "pos": [18, 19]}}
{"token": ["Serum", "anti-GQ1b", "antibodies", "are", "strongly", "associated", "with", "ophthalmoplegia", "in", "patients", "with", "C0393799#ent", "<e1>", "MFS", ")", "and", "Guillain-Barr\u00e9", "syndrome", "C4083008#ent", "<e2>", ")", "."], "h": {"id": "C0393799", "name": "C0393799#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4083008", "name": "C4083008#ent", "pos": [18, 19]}}
{"token": ["Recently", ",", "we", "described", "a", "low", "frequency", "platelet", "alloantigen", "human", "platelet", "membrane", "glycoprotein", "GP", ")", "IIIa", ",", "termed", "C1420394#ent", "<e1>", ",", "that", "was", "involved", "in", "neonatal", "C3853779#ent", "<e2>"], "h": {"id": "C1420394", "name": "C1420394#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3853779", "name": "C3853779#ent", "pos": [26, 27]}}
{"token": ["Preliminary", "studies", "of", "family", "history", "bipolar", "disorder", "of", "X-linkage", "of", "personality", "traits", "C0155015#ent", "<e1>", "suggested", "a", "\"", "quantitative", "trait", "locus", "(", "C3826857#ent", "<e2>", ")", "approach", "to", "the", "genetics", "of", "normal", "personality", "."], "h": {"id": "C0155015", "name": "C0155015#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3826857", "name": "C3826857#ent", "pos": [21, 22]}}
{"token": ["To", "identify", "the", "major", "human", "cytochrome", "P450", "P450", ")", "participating", "in", "C0073716#ent", "<e1>", "oxidative", "metabolism", "human", "liver", "microsomes", "and", "C1704724#ent", "<e2>", "human", "P450", "were", "studied", "."], "h": {"id": "C0073716", "name": "C0073716#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704724", "name": "C1704724#ent", "pos": [19, 20]}}
{"token": ["Further", ",", "C0079083#ent", "<e1>", "also", "suppressed", "the", "C0907533#ent", "<e2>", "IkappaBalpha", "phosphorylation", "leading", "to", "stabilization", "of", "IkappaBalpha", "protein", "the", "cells", "."], "h": {"id": "C0079083", "name": "C0079083#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}}
{"token": ["The", "radiological", "findings", "in", "25", "patients", "with", "C0043407#ent", "<e1>", "their", "distinction", "from", "C0010346#ent", "<e2>", "described", "."], "h": {"id": "C0043407", "name": "C0043407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [12, 13]}}
{"token": ["Not", "all", "of", "the", "6", "classical", "lesions", "(", "hemangioblastoma", "of", "the", "CNS", ",", "retinal", "angiomatosis", "pancreatic", "cysts", "renal", "cysts", "carcinoma", ",", "pheochromocytoma", "and", "C0037859#ent", "<e1>", "are", "present", "in", "C0019562#ent", "<e2>", "families", "."], "h": {"id": "C0037859", "name": "C0037859#ent", "pos": [23, 24]}, "relation": "manifestation_of", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [28, 29]}}
{"token": ["C0037859#ent", "<e1>", "ECs", ")", "are", "frequently", "found", "in", "association", "with", "von", "Hippel-Lindau", "disease", "C0019562#ent", "<e2>", ")", ",", "but", "little", "has", "been", "reported", "about", "their", "sonographic", "appearance", "."], "h": {"id": "C0037859", "name": "C0037859#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0019562", "name": "C0019562#ent", "pos": [13, 14]}}
{"token": ["Murine", "C0006035#ent", "<e1>", "characterized", "by", "arthritis", "and", "C0869523#ent", "<e2>", "that", "are", "most", "severe", "at", "2", "to", "3", "wk", ",", "then", "regress", "during", "the", "course", "of", "persistent", "infection", "."], "h": {"id": "C0006035", "name": "C0006035#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0869523", "name": "C0869523#ent", "pos": [7, 8]}}
{"token": ["Following", "treatment", "with", "100", "U/ml", "of", "rabbit", "C1415900#ent", "<e1>", ",", "both", "cell", "strains", "VSV", "yield", "about", "a", "1000-fold", ";", "C0042214#ent", "<e2>", "is", "not", "inhibited", "by", "C1415900#ent", "<e1>", "in", "either", "cell", "strain"], "h": {"id": "C0042214", "name": "C0042214#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [7, 8]}}
{"token": ["C0089795#ent", "<e1>", "diminished", "or", "abolished", "cell", "surface", "expression", "of", "DAF", "and", "C3272448#ent", "<e2>", "on", "BAEC", "."], "h": {"id": "C0089795", "name": "C0089795#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272448", "name": "C3272448#ent", "pos": [11, 12]}}
{"token": ["Fourteen", "patients", "had", "intractable", "sepsis", "resulting", "from", "C1541923#ent", "<e1>", "myocardial", "abscess", "10", "patients", "had", "C0009450#ent", "<e2>"], "h": {"id": "C1541923", "name": "C1541923#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [14, 15]}}
{"token": ["C1704436#ent", "<e1>", "PAD", ")", "is", "most", "frequently", "caused", "by", "C0004153#ent", "<e2>", "."], "h": {"id": "C1704436", "name": "C1704436#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [9, 10]}}
{"token": ["C1704436#ent", "<e1>", "PAD", ")", ",", "like", "coronary", "heart", "disease", "is", "a", "clinical", "manifestation", "C0004153#ent", "<e2>", "and", "is", "associated", "with", "increased", "mortality", "."], "h": {"id": "C1704436", "name": "C1704436#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [13, 14]}}
{"token": ["This", "study", "aims", "to", "determine", "the", "effect", "of", "glucose", "and", "glucose", "polymers", "C3811116#ent", "<e1>", ")", "from", "corn", "in", "oral", "rehydration", "solutions", "ORS", ")", "on", "C0012610#ent", "<e2>", "and", "morphometric", "measurements", "small", "intestinal", "mucosa", "rats", "."], "h": {"id": "C3811116", "name": "C3811116#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012610", "name": "C0012610#ent", "pos": [24, 25]}}
{"token": ["In", "addition", "to", "biliary", "atresia", "intrahepatic", "cholestasis", "to", "C0010674#ent", "<e1>", "severe", "neonatal", "C0019159#ent", "<e2>", "may", "also", "cause", "bowel", "nonvisualization", "up", "to", "24", "hours", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [12, 13]}}
{"token": ["Two", "had", "no", "bowel", "activity", "24", "hours", ":", "one", "had", "C0010674#ent", "<e1>", "one", "had", "neonatal", "C0019159#ent", "<e2>", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [15, 16]}}
{"token": ["Virulent", "organisms", "induced", "early", "C1705341#ent", "<e1>", "activation", "and", "the", "tyrosine", "phosphorylation", "several", "endogenous", "substrates", ",", "including", "C0084219#ent", "<e2>", "and", "Lyn", ",", "two", "Src-related", "kinases", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0084219", "name": "C0084219#ent", "pos": [16, 17]}}
{"token": ["C0062907#ent", "<e1>", "been", "shown", "to", "inhibit", "endogenous", "C0012920#ent", "<e2>", "activity", "."], "h": {"id": "C0062907", "name": "C0062907#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012920", "name": "C0012920#ent", "pos": [7, 8]}}
{"token": ["C1416661#ent", "<e1>", "interacts", "with", "C1334032#ent", "<e2>", "in", "the", "cell", "and", "in", "vitro"], "h": {"id": "C1416661", "name": "C1416661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [4, 5]}}
{"token": ["Therefore", ",", "anti-epileptic", "drugs", "like", "C0700087#ent", "<e1>", "can", "be", "effective", "in", "controlling", "C0040997#ent", "<e2>", "the", "majority", "of", "patients", ",", "at", "least", "in", "the", "initial", "stages", "."], "h": {"id": "C0700087", "name": "C0700087#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040997", "name": "C0040997#ent", "pos": [12, 13]}}
{"token": ["Three", "cDNA", "clones", "encoding", "C0010662#ent", "<e1>", "O-acetylserine", "(", "thiol", ")", "lyase", ",", "C3853653#ent", "<e2>", "were", "isolated", "from", "Arabidopsis", "thaliana", "designated", "AtcysC1", ",", "AtcysD1", "and", "AtcysD2", ",", "respectively", "."], "h": {"id": "C0010662", "name": "C0010662#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3853653", "name": "C3853653#ent", "pos": [12, 13]}}
{"token": ["This", "CFA-induced", "increase", "in", "C1705791#ent", "<e1>", "phosphorylation", "was", "mediated", "through", "trk", "receptors", "because", "intrathecal", "treatment", "with", "the", "tyrosine", "kinase", "inhibitor", "C0124355#ent", "<e2>", ",", "reduced", "the", "activation", "of", "C1705791#ent", "<e1>", "."], "h": {"id": "C0124355", "name": "C0124355#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [4, 5]}}
{"token": ["IBMX", "(", "3-isobutyl-1-methylxanthine", ")", "(", "cyclic", "nucleotide", "phosphodiesterase", "inhibitor", "enhanced", "the", "achatin-I-induced", "Iin", "of", "v-RCDN", ",", "but", "this", "C0013227#ent", "<e1>", "was", "ineffective", "on", "the", "Iin", "of", "C1418754#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1418754", "name": "C1418754#ent", "pos": [26, 27]}}
{"token": ["Cytochrome", "c", "2,5-DHBA", "production", ",", "and", "C0007367#ent", "<e1>", "almost", "completely", "inhibited", "2,5-DHBA", "production", ",", "while", "C0067309#ent", "<e2>", "had", "no", "effect", "2,5-DHBA", "production", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0067309", "name": "C0067309#ent", "pos": [15, 16]}}
{"token": ["Vascular", "endothelial", "growth", "factor", "VEGF", ")", "and", "C1366557#ent", "<e1>", "induced", "the", "expression", "of", "C1415855#ent", "<e2>", "and", "Id3", "in", "HUVECs", "."], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415855", "name": "C1415855#ent", "pos": [13, 14]}}
{"token": ["The", "lipid", "derivatives", "anandamide", "and", "C0299477#ent", "<e1>", "act", "as", "endogenous", "ligands", "for", "CB(1", ")", "receptors", "(", "C2347556#ent", "<e2>", ")", "."], "h": {"id": "C0299477", "name": "C0299477#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2347556", "name": "C2347556#ent", "pos": [16, 17]}}
{"token": ["The", "activities", "of", "C0029279#ent", "<e1>", "as", "a", "marker", "of", "mitochondria", ")", "and", "C0041487#ent", "<e2>", "as", "a", "marker", "of", "cytosol", ")", "were", "clearly", "suppressed", "by", "sodium", "benzoate", "concentration", "in", "excess", "of", "500", "micrograms/ml", "."], "h": {"id": "C0029279", "name": "C0029279#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041487", "name": "C0041487#ent", "pos": [12, 13]}}
{"token": ["Eosinophilic", "ulcer", "of", "the", "oral", "mucosa", "EUOM", ")", "is", "an", "uncommon", "self-limited", "oral", "condition", "that", "clinically", "manifests", "as", "a", "C0016167#ent", "<e1>", "elevated", "indurate", "borders", "affecting", "the", "tongue", ",", "buccal", "mucosa", "C3889123#ent", "<e2>", "."], "h": {"id": "C0016167", "name": "C0016167#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3889123", "name": "C3889123#ent", "pos": [30, 31]}}
{"token": ["Heparin", "or", "enzymatic", "degradation", "C0062507#ent", "<e1>", ",", "but", "not", "with", "C0024188#ent", "<e2>", "release", "thrombospondin", "from", "the", "cell", "surface"], "h": {"id": "C0062507", "name": "C0062507#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0024188", "name": "C0024188#ent", "pos": [10, 11]}}
{"token": ["Peripheral", "administration", "C2697656#ent", "<e1>", "promoted", "mast", "cell", "degranulation", "and", "increased", "C0047123#ent", "<e2>", ",", "BT", ",", "mucosal", "myeloperoxidase", "activity", "well", "as", "rat", "mast", "cell", "protease", "2", "levels", ",", "and", "PA", "in", "colonic", "content", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0047123", "name": "C0047123#ent", "pos": [10, 11]}}
{"token": ["Influenza", "A", "viruses", "a", "N1", "subtype", "influenza", "B", "strains", "demonstrated", "a", "greater", "sensitivity", "to", "C0216660#ent", "<e1>", "than", "to", "oseltamivir", "carboxylate", "whereas", "C0021400#ent", "<e2>", "a", "N2", "subtype", "more", "susceptible", "to", "oseltamivir", "carboxylate"], "h": {"id": "C0216660", "name": "C0216660#ent", "pos": [14, 15]}, "relation": "may_prevent", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [21, 22]}}
{"token": ["Results", "demonstrated", "50", "-", "70", "%", "low", "relative", "capacities", "of", "the", "recombinant", "mouse", "and", "triple", "mutant", "C2983548#ent", "<e1>", "to", "phosphorylate", "this", "nucleoside", "analogs", "with", "human", "C1333205#ent", "<e2>", "."], "h": {"id": "C2983548", "name": "C2983548#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333205", "name": "C1333205#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "bulimic", "patients", "with", "normal", "glucose", "tolerance", "a", "family", "history", "C0011847#ent", "<e1>", "were", "characterized", "by", "normal", "insulin", "secretion", "normal", "C1420066#ent", "<e2>", ",", "and", "reduced", "SG", "and", "GEZI", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "expression", "of", "the", "C1333245#ent", "<e1>", "DHR1", "domain", "sufficient", "to", "restore", "the", "perturbed", "C1334090#ent", "<e2>", "distribution", "in", "C1333245#ent", "<e1>", "knockdown", "cells"], "h": {"id": "C1333245", "name": "C1333245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334090", "name": "C1334090#ent", "pos": [14, 15]}}
{"token": ["During", "this", "process", ",", "expression", "of", "caspase", "3", "C0538091#ent", "<e1>", "BAX", ",", "bcl-x", ",", "TRPM-2", ",", "and", "MMP7", "C0017337#ent", "<e2>", "was", "apparently", "increased", "."], "h": {"id": "C0538091", "name": "C0538091#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["Both", "abilities", "of", "C1413355#ent", "<e1>", "can", "be", "inhibited", "by", "C4277588#ent", "<e2>", "such", "as", "phosphatidylinositol", ",", "phosphatidylinositol", "4-monophosphate", "and", "phosphatidylinositol", "4,5-bisphosphate", "PIP2", ")", "."], "h": {"id": "C1413355", "name": "C1413355#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4277588", "name": "C4277588#ent", "pos": [9, 10]}}
{"token": ["The", "nucleotide", "sequence", "determined", "of", "a", "light-inducible", "gene", "(", "lipA", ")", "that", "encodes", "the", "precursor", "of", "a", "light-inducible", "pilin", "(", "designated", "C1846919#ent", "<e1>", ")", ",", "a", "polypeptide", "of", "212", "C3539946#ent", "<e2>"], "h": {"id": "C1846919", "name": "C1846919#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [29, 30]}}
{"token": ["In", "a", "prospective", "study", "patients", "with", "C0042029#ent", "<e1>", "by", "sulphonamide-sensitive", "organisms", "were", "treated", "with", "single", "oral", "dose", "the", "C0038745#ent", "<e2>"], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0038745", "name": "C0038745#ent", "pos": [18, 19]}}
{"token": ["An", "understanding", "of", "muscle", "structure", "function", "is", "central", "to", "improving", "our", "knowledge", "of", "the", "group", "of", "C0026848#ent", "<e1>", "to", "as", "C0026850#ent", "<e2>"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0026850", "name": "C0026850#ent", "pos": [20, 21]}}
{"token": ["Also", "included", "is", "an", "abbreviated", "reference", "table", "of", "important", "C3850052#ent", "<e1>", "isoenzyme", "inhibition", "by", "C0360105#ent", "<e2>", ",", "and", "selected", "psychotropic", "and", "somatic", "medication", "substrates", "."], "h": {"id": "C3850052", "name": "C3850052#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0360105", "name": "C0360105#ent", "pos": [14, 15]}}
{"token": ["This", "device", "was", "implanted", "because", "of", "a", "C0004245#ent", "<e1>", "occurred", "during", "an", "operation", "for", "tetralogy", "of", "C1418436#ent", "<e2>", "."], "h": {"id": "C0004245", "name": "C0004245#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418436", "name": "C1418436#ent", "pos": [16, 17]}}
{"token": ["Confocal", "studies", "of", "C3539652#ent", "<e1>", "isolated", "from", "human", "tonsil", "revealed", "that", "C3539604#ent", "<e2>", "was", "present", "in", "the", "cytoplasm", "."], "h": {"id": "C3539652", "name": "C3539652#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539604", "name": "C3539604#ent", "pos": [11, 12]}}
{"token": ["To", "identify", "the", "C1417679#ent", "<e1>", "for", "FCAS", "and", "C0796033#ent", "<e2>", ",", "we", "screened", "exons", "in", "the", "1q44", "region", "for", "mutations", "by", "direct", "sequencing", "genomic", "DNA", "affected", "individuals", "and", "controls", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0796033", "name": "C0796033#ent", "pos": [8, 9]}}
{"token": ["In", "addition", ",", "renal", "function", "serum", "lipid", "levels", "histopathology", "(", "C0852949#ent", "<e1>", "and", "tubulointerstitial", "fibrosis", ",", "and", "the", "expression", "of", "the", "vasoactive", "factors", "C0907532#ent", "<e2>", "eNOS", ")", "and", "renin", "protein", "also", "compared", "for", "different", "treatment", "groups"], "h": {"id": "C0852949", "name": "C0852949#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0907532", "name": "C0907532#ent", "pos": [23, 24]}}
{"token": ["Analysis", "by", "reverse", "transcription-polymerase", "chain", "reaction", "that", "C0024727#ent", "<e1>", ",", "OM", "and", "RM", "also", "stimulated", "up-regulation", "of", "inflammatory", "cytokines", "C0534519#ent", "<e2>", "and", "tumour", "necrosis", "factor-alpha", "and", "differential", "T", "helper", "1", "cytokines", "."], "h": {"id": "C0024727", "name": "C0024727#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [19, 20]}}
{"token": ["Intermediate", "affinity", "5-", "to", "40-fold", "lower", ")", "was", "observed", "with", "C0031684#ent", "<e1>", "corresponding", "to", "the", "regulatory", "domains", "C0080298#ent", "<e2>", "and", "Lck", ",", "containing", "Tyr527", "and", "Tyr505", ",", "respectively", "."], "h": {"id": "C0031684", "name": "C0031684#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [17, 18]}}
{"token": ["Loop", "diuretics", "with", "or", "without", "C0025854#ent", "<e1>", "or", "a", "thiazide", "diuretic", "are", "quite", "useful", "in", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0025854", "name": "C0025854#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["These", "data", "suggest", "that", "C1417905#ent", "<e1>", "would", "be", "effective", "against", "various", "C0012634#ent", "<e2>", "whose", "pathogenesis", "is", "active", "oxygen-related", "."], "h": {"id": "C1417905", "name": "C1417905#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}}
{"token": ["Our", "findings", "suggest", "that", "DNMT1", "plays", "a", "key", "role", "in", "maintenance", "of", "methylation", ",", "and", "C1452577#ent", "<e1>", "may", "act", "as", "an", "C0012873#ent", "<e2>", "epigenetically", "silence", "CXCL12", "expression", "in", "MCF-7", "and", "AsPC1", "cells"], "h": {"id": "C1452577", "name": "C1452577#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0012873", "name": "C0012873#ent", "pos": [21, 22]}}
{"token": ["We", "report", "two", "men", "with", "C0014038#ent", "<e1>", "LE", ")", "refractory", "to", "C3540727#ent", "<e2>", ",", "IVIg", "and", "plasma", "exchange"], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540727", "name": "C3540727#ent", "pos": [11, 12]}}
{"token": ["C1422417#ent", "<e1>", "RMCP-1", ")", "is", "a", "chymotrypsin-like", "serine", "protease", "C4084825#ent", "<e2>", ")", "that", "is", "specifically", "expressed", "by", "connective-tissue-type", "mast", "cells", "."], "h": {"id": "C1422417", "name": "C1422417#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4084825", "name": "C4084825#ent", "pos": [9, 10]}}
{"token": ["C1415900#ent", "<e1>", "could", "be", "observed", "in", "the", "C1705928#ent", "<e2>", ",", "regardless", "of", "the", "H-2", "haplotype", "the", "mouse", "strains", "with", "the", "exception", "of", "NZB", "mice", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705928", "name": "C1705928#ent", "pos": [7, 8]}}
{"token": ["Oxidative", "stress", "humans", "with", "C1956346#ent", "<e1>", "also", "exacerbated", "by", "a", "reduction", "of", "C1420308#ent", "<e2>", "normally", "an", "important", "protective", "enzyme", "against", "the", "superoxide", "anion"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420308", "name": "C1420308#ent", "pos": [12, 13]}}
{"token": ["The", "configurations", "of", "immunoglobulin", "genes", "T-cell", "receptor", "TCR", ")", "C1706333#ent", "<e1>", "bcl-2", "genes", "analyzed", "by", "Southern", "blotting", "C0011519#ent", "<e2>", "derived", "from", "35", "fine", "needle", "aspiration", "biopsies", "from", "various", "lymphoproliferative", "disorders"], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [17, 18]}}
{"token": ["A", "third", "type", "of", "C0909712#ent", "<e1>", "NDP", "kinase", "III", ",", "distinct", "from", "the", "previously", "described", "C0093999#ent", "<e2>", "II", "(", "Nomura", "et", "al.", "(", "1991", ")", "Biochim", "."], "h": {"id": "C0909712", "name": "C0909712#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0093999", "name": "C0093999#ent", "pos": [15, 16]}}
{"token": ["A", "history", "of", "asthma", ",", "C0018621#ent", "<e1>", "and", "flexural", "eczema", "significantly", "more", "common", "in", "patients", "with", "adult", "C0007570#ent", "<e2>", "A.C.D.", ")", "than", "in", "normal", "controls"], "h": {"id": "C0018621", "name": "C0018621#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [17, 18]}}
{"token": ["A", "monoclonal", "antibody", "generated", "against", "the", "C0012544#ent", "<e1>", "highly", "stereoselective", "for", "(R)-isomer", "in", "C0054741#ent", "<e2>", "racemic", "ester", "2"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [13, 14]}}
{"token": ["Prevalence", "of", "C0029896#ent", "<e1>", "of", "the", "lens", "and", "C1256254#ent", "<e2>", "increased", "significantly", "with", "increasing", "age", "(", "p", "<", "0.001", ")", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1256254", "name": "C1256254#ent", "pos": [8, 9]}}
{"token": ["In", "C0029896#ent", "<e1>", "that", "produce", "neovascularization", "of", "the", "C1256254#ent", "<e2>", "(", "NVI", ")", ",", "such", "as", "diabetes", "mellitus", "central", "retinal", "vein", "obstruction", "a", "judiciously", "timed", "PRP", "can", "reduce", "the", "incidence", "of", "neovascular", "glaucoma"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1256254", "name": "C1256254#ent", "pos": [8, 9]}}
{"token": ["Immunoprecipitation", "experiments", "that", ",", "in", "human", "and", "mouse", "cells", "complex", "formation", "occurs", "between", "Dicer", "and", "C2827476#ent", "<e1>", "or", "2", "and", "that", "the", "PIWI", "domain", "C1414332#ent", "<e2>", "is", "essential", "for", "the", "formation", "of", "this", "complex", "."], "h": {"id": "C2827476", "name": "C2827476#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414332", "name": "C1414332#ent", "pos": [24, 25]}}
{"token": ["C1426338#ent", "<e1>", "and/or", "RepR", "were", "supplied", "in", "trans", ",", "and", "C0022959#ent", "<e2>", "synthesis", "measured", "."], "h": {"id": "C1426338", "name": "C1426338#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022959", "name": "C0022959#ent", "pos": [10, 11]}}
{"token": ["However", ",", "only", "the", "JNK1", "isoform", "was", "phosphorylated", "and", ",", "as", "determined", "in", "single", "knock-out", "mice", "was", "necessary", "for", "C1333257#ent", "<e1>", "induction", "by", "C1524095#ent", "<e2>", "or", "LPS", "."], "h": {"id": "C1333257", "name": "C1333257#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1524095", "name": "C1524095#ent", "pos": [23, 24]}}
{"token": ["These", "disease/gene", "matches", "include", "the", "oculorenal", "syndrome", "PAX2", ";", "aniridia", "and", "PAX6", ";", "C3495488#ent", "<e1>", "RIEG1/PITX2", ";", "cyclopia", "and", "Sonic", "hedgehog", "cone-rod", "dystrophy", "Leber's", "congenital", "amaurosis", "C1413723#ent", "<e2>", ";", "and", "recessive", "septooptic", "dysplasia", "HESX1", "."], "h": {"id": "C3495488", "name": "C3495488#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413723", "name": "C1413723#ent", "pos": [26, 27]}}
{"token": ["In", "summary", ",", "VCAM-1", "activates", "endothelial", "cell", "NADPH", "oxidase", "generate", "C0812281#ent", "<e1>", ",", "resulting", "in", "oxidative", "activation", "PKCalpha", "and", "then", "serine", "phosphorylation", "C1709439#ent", "<e2>", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1709439", "name": "C1709439#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "intracortical", "infusion", "of", "C0245109#ent", "<e1>", "failed", "to", "inhibit", "NMDA", "or", "C1704949#ent", "<e2>", "receptor-induced", "damage", "in", "the", "cortex", "."], "h": {"id": "C0245109", "name": "C0245109#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [13, 14]}}
{"token": ["A", "study", "of", "31", "continuing", "pregnancies", "complicated", "by", "C0011881#ent", "<e1>", "conducted", "to", "determine", "the", "effects", "of", "C1415831#ent", "<e2>", "maternal", "health", "fetal", "outcome"], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415831", "name": "C1415831#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "it", "has", "been", "showed", "that", "C0017925#ent", "<e1>", "mutations", "in", "the", "C1412638#ent", "<e2>", "at", "12q24.1", "."], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412638", "name": "C1412638#ent", "pos": [12, 13]}}
{"token": ["C0017925#ent", "<e1>", "caused", "by", "mutations", "in", "the", "C1412638#ent", "<e2>", "which", "maps", "to", "chromosome", "12q23-q24.1", "encodes", "the", "sarcoplasmic/endoplasmic", "reticulum", "calcium", "ATPase", "SERCA2", ")", "."], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412638", "name": "C1412638#ent", "pos": [7, 8]}}
{"token": ["C0917783#ent", "<e1>", "activity", "remained", "elevated", "for", "60", "minutes", "after", "exposure", "to", "C0000970#ent", "<e2>", "(", "124", "microliters/g", "protein", ")", "."], "h": {"id": "C0917783", "name": "C0917783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [11, 12]}}
{"token": ["Accordingly", ",", "there", "is", "a", "high", "degree", "of", "polymorphism", "in", "many", "C0017337#ent", "<e1>", "within", "the", "MHC", ",", "the", "most", "notable", "being", "the", "C0599797#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0599797", "name": "C0599797#ent", "pos": [22, 23]}}
{"token": ["Sequencing", "of", "the", "RT-PCR", "products", "revealed", "that", "the", "C1418445#ent", "<e1>", "transcripts", "from", "the", "C1706112#ent", "<e2>", "with", "IVS7", "-", "2A-->G", "mutation", "lose", "the", "entire", "exon", "8", "resulting", "in", "a", "joining", "of", "exons", "7", "9", "."], "h": {"id": "C1418445", "name": "C1418445#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [13, 14]}}
{"token": ["The", "main", "categories", "of", "relevant", "diseases", "include", "different", "types", "of", "C0027868#ent", "<e1>", "chest-wall", "deformities", "and", "even", "C0024115#ent", "<e2>"], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [16, 17]}}
{"token": ["They", "were", "different", "from", "those", "of", "rat", "C1418617#ent", "<e1>", "but", "very", "similar", "to", "those", "of", "C3539768#ent", "<e2>", "secreted", "from", "rat", "platelets", "."], "h": {"id": "C1418617", "name": "C1418617#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [15, 16]}}
{"token": ["Data", "from", "cohort", "studies", "untreated", "groups", "in", "randomized", "controlled", "trials", "be", "identified", "through", "systematic", "literature", "review", "synthesized", "with", "meta-analysis", "to", "estimate", "natural", "history", "C2827407#ent", "<e1>", "AOM", ")", "and", "C0029882#ent", "<e2>", "effusion", "(", "OME", ")", "."], "h": {"id": "C2827407", "name": "C2827407#ent", "pos": [23, 24]}, "relation": "has_nichd_parent", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [28, 29]}}
{"token": ["C0012695#ent", "<e1>", "treatment", "induced", "losses", "of", "C2697656#ent", "<e2>", "(", "up", "to", "40", "%", ")", ",", "outer", "membrane", "proteins", "OmpA", ",", "OmpF/C", ",", "and", "lipoprotein", ",", "periplasmic", "proteins", "and", "phosphatidylethanolamine", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [6, 7]}}
{"token": ["Initial", "studies", "in", "barbital-acetate", "buffer", "showed", "that", "C0012695#ent", "<e1>", "and", "lactoferrin", "cause", "significant", "release", "of", "C2697656#ent", "<e2>", "from", "all", "three", "strains", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [15, 16]}}
{"token": ["Glypican-1", ",", "syndecan-3", "and", "syndecan-4", "were", "the", "major", "cell-membrane", "C2987155#ent", "<e1>", "species", "and", "perlecan", "was", "the", "major", "C3889469#ent", "<e2>", "proteoglycan", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3889469", "name": "C3889469#ent", "pos": [17, 18]}}
{"token": ["The", "majority", "of", "the", "C0024535#ent", "<e1>", "cases", "were", "treated", "with", "C0120726#ent", "<e2>", "or", "sulfadoxine-pyrimethamine", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0120726", "name": "C0120726#ent", "pos": [10, 11]}}
{"token": ["C1706586#ent", "<e1>", "required", "for", "the", "proliferation", "of", "growth", "factor", "cell", "lines", "stimulated", "by", "C0879590#ent", "<e2>", ",", "IL-3", ",", "G-CSF", ",", "GM-CSF", "and", "EPO", "that", "bind", "to", "the", "hematopoietin", "class", "of", "receptors"], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [13, 14]}}
{"token": ["Safingol", "[", "C0888599#ent", "<e1>", "]", ",", "a", "sphingosine", "analog", "inhibits", "C0033634#ent", "<e2>", "was", "developed", "to", "treat", "dermatoses", "and", "cancer", "."], "h": {"id": "C0888599", "name": "C0888599#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [10, 11]}}
{"token": ["C0029298#ent", "<e1>", "EC", "2.4.2.14", ",", "is", "separable", "from", "both", "AS", "I", "C3273406#ent", "<e2>", ",", "and", "is", "not", "required", "for", "anthranilate", "synthesis"], "h": {"id": "C0029298", "name": "C0029298#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "two", "human", "C0079427#ent", "<e1>", "p53", "and", "the", "ATM", "(", "C1705846#ent", "<e2>", "may", "provide", "some", "answers", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705846", "name": "C1705846#ent", "pos": [11, 12]}}
{"token": ["To", "further", "define", "the", "repertoire", "of", "proteins", "involved", "in", "FSH-induced", "signal", "transduction", "several", "signaling", "and", "C1332163#ent", "<e1>", "examined", "for", "the", "ability", "to", "associate", "with", "C2986690#ent", "<e2>", "."], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2986690", "name": "C2986690#ent", "pos": [24, 25]}}
{"token": ["C0065374#ent", "<e1>", "group", "and", "C0064568#ent", "<e2>", "group", "achieved", "similar", "and", "highly", "significant", "reduction", "in", "blood", "pressure", "P", "<", "0.001", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0064568", "name": "C0064568#ent", "pos": [4, 5]}}
{"token": ["Two", "additional", "groups", "of", "PHN", "rats", "received", "C0065374#ent", "<e1>", "(", "40", "mg/L", ")", "or", "a", "calcium", "channel", "blocker", "C0064568#ent", "<e2>", ",", "3", "mg/kg", ")", "from", "day", "7", "after", "surgery", "to", "8", "months", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0064568", "name": "C0064568#ent", "pos": [18, 19]}}
{"token": ["The", "C0040083#ent", "<e1>", "TP", ")", "then", "hydrolyzes", "5'-DFUR", "to", "the", "C0013227#ent", "<e2>", "5-FU", "."], "h": {"id": "C0040083", "name": "C0040083#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["In", "this", "respect", ",", "it", "was", "comparable", "or", "superior", "to", "flunitrazepam", "and", "C0016375#ent", "<e1>", "and", "comparable", "to", "other", "C0005064#ent", "<e2>", "in", "patients", "with", "insomnia", "."], "h": {"id": "C0016375", "name": "C0016375#ent", "pos": [12, 13]}, "relation": "has_structural_class", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [18, 19]}}
{"token": ["An", "extensive", "C0037198#ent", "<e1>", "secondary", "to", "silent", "otitis", "media", "in", "a", "patient", "with", "a", "C1704321#ent", "<e2>", "is", "presented", "."], "h": {"id": "C0037198", "name": "C0037198#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [14, 15]}}
{"token": ["Although", "this", "serine", "fell", "within", "a", "consensus", "sequence", "phosphorylation", "by", "the", "C1956039#ent", "<e1>", "experiments", "with", "mutant", "CHO", "cells", "defective", "in", "these", "C3540017#ent", "<e2>", "indicated", "that", "it", "was", "not", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [21, 22]}}
{"token": ["Function", "blocking", "anti-fibroblast", "growth", "factor-2", "FGF-2", ")", "antibody", "enhanced", "C0024375#ent", "<e1>", "expression", "in", "the", "absence", "of", "C0038880#ent", "<e2>", "."], "h": {"id": "C0024375", "name": "C0024375#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [16, 17]}}
{"token": ["Noninflammatory", "fibrotic", "degeneration", "of", "cardiac", "valves", "been", "reported", "to", "occur", "in", "patients", "with", "C0024586#ent", "<e1>", "to", "occasionally", "complicate", "therapies", "with", "the", "C0014710#ent", "<e2>", "methysergide", "and", "with", "the", "appetite", "suppressants", "fenfluramine", "and", "dexfenfluramine", "."], "h": {"id": "C0024586", "name": "C0024586#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014710", "name": "C0014710#ent", "pos": [21, 22]}}
{"token": ["The", "coexistence", "of", "Fabry's", "disease", "an", "C0949683#ent", "<e1>", "and", "other", "C0012634#ent", "<e2>", "has", "rarely", "been", "described", "in", "the", "same", "patient", "."], "h": {"id": "C0949683", "name": "C0949683#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["Because", "of", "its", "bifunctional", "role", "as", "both", "a", "C1419277#ent", "<e1>", "and", "a", "SNX", ",", "RGS-PX1", "may", "link", "C0752348#ent", "<e2>", "vesicular", "trafficking", "."], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [17, 18]}}
{"token": ["Sst2", "functions", "as", "a", "GTPase", "activating", "protein", "C1419277#ent", "<e1>", ")", "for", "the", "Galpha", "subunit", "the", "C0752348#ent", "<e2>"], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [15, 16]}}
{"token": ["This", "course", "of", "events", "helps", "to", "explain", "why", "patients", "with", "C0002962#ent", "<e1>", "more", "prone", "to", "C0008031#ent", "<e2>", "a", "meal", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0008031", "name": "C0008031#ent", "pos": [15, 16]}}
{"token": ["All", "had", "recent", "onset", ",", "or", "increasing", "frequency", "of", "C0002962#ent", "<e1>", "excluding", "those", "with", "suspected", "myocardial", "infarction", "C0008031#ent", "<e2>", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0008031", "name": "C0008031#ent", "pos": [17, 18]}}
{"token": ["Different", "ratios", "of", "the", "gp42", "and", "gH", "glycoproteins", "the", "envelope", "of", "virions", "that", "were", "derived", "from", "major", "C0024518#ent", "<e1>", "or", "-negative", "cells", "accounted", "primarily", "for", "the", "differences", "in", "C0149678#ent", "<e2>", "tropism", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [28, 29]}}
{"token": ["The", "mechanisms", "of", "C0024518#ent", "<e1>", "MHC", ")", "class", "I", "downregulation", "during", "Epstein-Barr", "virus", "C0149678#ent", "<e2>", ")", "replication", "are", "not", "well", "characterized", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [13, 14]}}
{"token": ["T", "cells", "these", "mice", "generate", "human", "major", "C0024518#ent", "<e1>", "class", "II-restricted", "adaptive", "immune", "responses", "to", "Epstein-Barr", "virus", "C0149678#ent", "<e2>", ")", "infection", "and", "are", "activated", "by", "human", "DCs", "to", "mount", "a", "potent", "T-cell", "immune", "response", "superantigens", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [17, 18]}}
{"token": ["Although", "the", "two", "species", "shared", "30", "polymorphic", "loci", "no", "correlation", "between", "C1334912#ent", "<e1>", "and", "PSE", "C0730321#ent", "<e2>", "values", "was", "obtained", "."], "h": {"id": "C1334912", "name": "C1334912#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0730321", "name": "C0730321#ent", "pos": [15, 16]}}
{"token": ["However", ",", "the", "conformation", "of", "C0751039#ent", "<e1>", "when", "bound", "to", "C1418796#ent", "<e2>", "is", "significantly", "different", "from", "that", "when", "bound", "to", "CyPA", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418796", "name": "C1418796#ent", "pos": [10, 11]}}
{"token": ["A", "novel", "C0019537#ent", "<e1>", "recently", "been", "described", "to", "be", "associated", "with", "expanded", "C0032500#ent", "<e2>"], "h": {"id": "C0019537", "name": "C0019537#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032500", "name": "C0032500#ent", "pos": [12, 13]}}
{"token": ["Using", "a", "transiently", "transfected", "green", "fluorescent", "protein-GR", "construct", ",", "we", "examined", "the", "effect", "of", "C0729218#ent", "<e1>", "and", "rapamycin", "on", "C1705401#ent", "<e2>", "translocation", "."], "h": {"id": "C0729218", "name": "C0729218#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [19, 20]}}
{"token": ["The", "biological", "properties", "the", "C1334873#ent", "<e1>", "are", "sensitive", "to", "modifications", "in", "both", "the", "C0266313#ent", "<e2>", "conserved", "and", "variable", "regions", "."], "h": {"id": "C1334873", "name": "C1334873#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0266313", "name": "C0266313#ent", "pos": [13, 14]}}
{"token": ["Protein", "spots", "excised", "from", "the", "2D", "gel", "their", "contents", "were", "analyzed", "by", "matrix-assisted", "laser", "desorption-ionization", "MALDI", ")", "or", "nanoelectrospray", "ionization", "time-of-flight", "(", "TOF", ")", "tandem", "mass", "spectrometry", "C0026269#ent", "<e1>", ")", "after", "in-gel", "digestion", "with", "C0041236#ent", "<e2>", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [34, 35]}}
{"token": ["We", "conclude", "that", "the", "rank", "order", "of", "potency", "of", "C2936516#ent", "<e1>", "block", "HERG", "is", "cisapride", ">", "renzapride", ">", "C0913506#ent", "<e2>", ">", "mosapride", "."], "h": {"id": "C2936516", "name": "C2936516#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0913506", "name": "C0913506#ent", "pos": [18, 19]}}
{"token": ["Segmental", "spasm", "C1256254#ent", "<e1>", "in", "Horner", "and", "C0853695#ent", "<e2>", "especially", ",", "nasal", "side", "of", "iridoplegia", "was", "seen", "in", "early", "stage", "C0853695#ent", "<e2>", "pupillary", "dynamics", "to", "light", "stimulus"], "h": {"id": "C1256254", "name": "C1256254#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0853695", "name": "C0853695#ent", "pos": [7, 8]}}
{"token": ["Several", "symptoms", "are", "present", "in", "a", "form", "of", "C0341268#ent", "<e1>", "defined", "as", "\"", "C0022104#ent", "<e2>", ",", "in", "which", "a", "lot", "of", "polymorphic", "aspects", "appear", "to", "coincide", "."], "h": {"id": "C0341268", "name": "C0341268#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [13, 14]}}
{"token": ["In", "the", "mechanism", "on", "C0042345#ent", "<e1>", "formation", ",", "appearance", "of", "the", "C0008161#ent", "<e2>", "peripheral", "fraction", "of", "neuroplasm", "is", "essentially", "important", "."], "h": {"id": "C0042345", "name": "C0042345#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008161", "name": "C0008161#ent", "pos": [11, 12]}}
{"token": ["Further", ",", "the", "fact", "that", "a", "putative", "C4053697#ent", "<e1>", "opposite", "effects", "on", "the", "production", "of", "secreted", "and", "intracellular", "C1705543#ent", "<e2>", "may", "have", "important", "implications", "for", "AD", "drug", "design"], "h": {"id": "C4053697", "name": "C4053697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [18, 19]}}
{"token": ["Progressive", "C4021534#ent", "<e1>", "also", "occur", "because", "of", "some", "C0275544#ent", "<e2>", "as", "those", "caused", "by", "Cytomegalovirus", "and", "Rubella", "virus"], "h": {"id": "C4021534", "name": "C4021534#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0275544", "name": "C0275544#ent", "pos": [8, 9]}}
{"token": ["Two", "other", "newly", "qualified", "doctors", "then", "underwent", "a", "formal", "training", "session", "before", ",", "as", "well", "as", "continuous", "instruction", ",", "C1705674#ent", "<e1>", "measurements", "in", "23", "C0030196#ent", "<e2>", "(", "experiment", "2", ")", "."], "h": {"id": "C1705674", "name": "C1705674#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [24, 25]}}
{"token": ["We", "have", "examined", "expression", "of", "the", "cystic", "fibrosis", "transmembrane", "conductance", "regulator", "C1413365#ent", "<e1>", ")", "and", "of", "the", "major", "pancreatic", "mucin", "C1705281#ent", "<e2>", ",", "in", "primary", "pancreatic", "duct", "vas", "deferens", "epithelial", "cells", "and", "in", "pancreatic", "duct", "cell", "lines"], "h": {"id": "C1413365", "name": "C1413365#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [20, 21]}}
{"token": ["Effect", "of", "UV-A", "irradiation", "on", "bacteriophage", "lambda", "the", "presence", "of", "afloqualone", "(", "AQ", ")", "was", "examined", "to", "obtain", "in", "vitro", "evidence", "for", "C0162830#ent", "<e1>", "potential", "of", "AQ", ",", "a", "C0007680#ent", "<e2>", "muscle", "relaxant", "."], "h": {"id": "C0162830", "name": "C0162830#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0007680", "name": "C0007680#ent", "pos": [29, 30]}}
{"token": ["When", "C0917964#ent", "<e1>", "cAMP", "levels", "were", "measured", ",", "C1425980#ent", "<e2>", "was", "inactive", "in", "this", "negatively", "coupled", "system", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1425980", "name": "C1425980#ent", "pos": [8, 9]}}
{"token": ["C3809468#ent", "<e1>", "has", "a", "central", "hypervariable", "region", "HVR", ")", "flanked", "by", "highly", "conserved", "C0002523#ent", "<e2>", "and", "carboxyl", "termini"], "h": {"id": "C3809468", "name": "C3809468#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002523", "name": "C0002523#ent", "pos": [13, 14]}}
{"token": ["SAR/egg-yolk", ">", "C4283882#ent", "<e1>", "diluents", ",", "and", "with", "C0010406#ent", "<e2>", ":", "Me(2)SO", ">", "glycerol", ">", "methanol", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010406", "name": "C0010406#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "the", "mechanism", "of", "human", "immunodeficiency", "virus", "C1839163#ent", "<e1>", "by", "using", "thrombopoietin", "(", "C0812443#ent", "<e2>", ")", "levels", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [14, 15]}}
{"token": ["The", "induction", "of", "C1839163#ent", "<e1>", "results", "in", "elevated", "levels", "of", "C0812443#ent", "<e2>", "(", "TPO", ")", ",", "which", "can", "be", "detected", "in", "the", "plasma", "of", "experimental", "animals"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [10, 11]}}
{"token": ["It", "is", "suggested", "that", "baclofen", "depresses", "the", "C0878773#ent", "<e1>", "a", "central", "action", "is", "unrelated", "to", "bicuculline", "sensitive", "C0242898#ent", "<e2>", "mechanisms", ",", "substance", "P", "glutamate", "neurotransmission", "that", "is", "possibly", "related", "to", "interference", "with", "opioid", "mechanisms"], "h": {"id": "C0878773", "name": "C0878773#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [17, 18]}}
{"token": ["This", "study", "aims", "to", "assess", "the", "behavior", "of", "the", "oscillometric", "parameters", "in", "60", "patients", "with", "C0004096#ent", "<e1>", "in", "39", "with", "C0010674#ent", "<e2>"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [20, 21]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "assess", "the", "ability", "of", "the", "forced", "oscillation", "technique", "FOT", ")", "to", "detect", "airway", "obstruction", "C0004096#ent", "<e1>", "children", "and", "in", "patients", "with", "C0010674#ent", "<e2>", "CF", ")", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}, "relation": "manifestation_of", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [28, 29]}}
{"token": ["C0033626#ent", "<e1>", "combined", "with", "C0398625#ent", "<e2>", "3", "cases", ",", "plasminogen", "deficiency", "2", "cases", "and", "reduced", "fibrinolytic", "capacity", "two", "."], "h": {"id": "C0033626", "name": "C0033626#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0398625", "name": "C0398625#ent", "pos": [4, 5]}}
{"token": ["Our", "results", "indicate", "that", "C1427541#ent", "<e1>", "is", "expressed", "and", "packaged", "into", "C1332402#ent", "<e2>", "during", "keratinization", "and", "likely", "plays", "crucial", "role(s", ")", "in", "keratinocyte", "differentiation", "and", "LG", "lipid", "metabolism", "contributing", "to", "skin", "lipid", "barrier", "formation", "."], "h": {"id": "C1427541", "name": "C1427541#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332402", "name": "C1332402#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "the", "complex", "formation", "of", "C0033036#ent", "<e1>", "and", "Axin", "enhances", "the", "phosphorylation", "of", "beta-catenin", "by", "C4283740#ent", "<e2>", "leading", "to", "the", "down-regulation", "of", "beta-catenin", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "C0272285#ent", "<e1>", "the", "pulmonary", "arteries", "amenable", "to", "thrombolytic", "therapy", "including", "C0032143#ent", "<e2>", ",", "whereas", "this", "regimen", "appears", "to", "have", "little", "effect", "on", "saphenous", "vein", "grafts"], "h": {"id": "C0272285", "name": "C0272285#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [13, 14]}}
{"token": ["Pre-treatment", "with", "C0030135#ent", "<e1>", "significantly", "blocked", "the", "effects", "of", "fluoxetine", "in", "the", "C1414830#ent", "<e2>", ",", "confirming", "the", "role", "of", "endogenous", "5-HT", "."], "h": {"id": "C0030135", "name": "C0030135#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414830", "name": "C1414830#ent", "pos": [12, 13]}}
{"token": ["Calvarial", "osteoblasts", "and", "stromal", "cells", "CTGF", "transgenics", "displayed", "decreased", "alkaline", "phosphatase", "C1412791#ent", "<e1>", "mRNA", "levels", "and", "reduced", "C0377148#ent", "<e2>", "BMP", ")", "signaling", "mothers", "decapentaplegic", ",", "Wnt/beta-catenin", ",", "and", "IGF-I/Akt", "signaling", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "whether", "anterior", "chamber", "paracentesis", "Carbogen", "inhalation", "therapy", "95", "%", "oxygen", ",", "5", "%", "carbon", "dioxide", "produce", "a", "significant", "difference", "in", "final", "visual", "acuity", "C0235267#ent", "<e1>", "with", "C0007688#ent", "<e2>", "CRAO", ")", ",", "compared", "with", "untreated", "C0235267#ent", "<e1>", "."], "h": {"id": "C0007688", "name": "C0007688#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [25, 26]}}
{"token": ["C0012386#ent", "<e1>", ",", "acetazolamide", ",", "and", "dipropylacetate", "facilitated", "the", "C0752324#ent", "<e2>"], "h": {"id": "C0012386", "name": "C0012386#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752324", "name": "C0752324#ent", "pos": [9, 10]}}
{"token": ["This", "phase", "of", "protection", "may", "involve", "survival", "kinase", "pathways", "as", "Akt", "and", "C0244989#ent", "<e1>", "GSK3", ")", "either", "increasing", "C0812281#ent", "<e2>", "removal", "or", "reducing", "mitochondrial", "C0812281#ent", "<e2>", "production", "."], "h": {"id": "C0244989", "name": "C0244989#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [18, 19]}}
{"token": ["Subsequent", "investigations", "showed", "that", "grapefruit", "juice", "by", "reducing", "presystemic", "C0015772#ent", "<e1>", "metabolism", "through", "selective", "post-translational", "down", "of", "C1142644#ent", "<e2>", "CYP3A4", ")", "expression", "in", "the", "intestinal", "wall"], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [9, 10]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [17, 18]}}
{"token": ["C0015772#ent", "<e1>", ",", "a", "dihydropyridine", "calcium", "antagonist", "is", "extensively", "metabolized", "by", "C1142644#ent", "<e2>", "."], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}}
{"token": ["High-dose", "C0025677#ent", "<e1>", "did", "not", "prevent", "the", "appearance", "of", "C0007682#ent", "<e2>", "there", "being", "2/15", "and", "3/15", "CNS", "relapses", "in", "the", "HD", "C0025677#ent", "<e1>", "and", "LD", "C0025677#ent", "<e1>", "treated", "groups", ",", "respectively", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [9, 10]}}
{"token": ["Both", "C0719425#ent", "<e1>", "and", "ethanol", "increased", "C1706383#ent", "<e2>", "mRNA", ",", "and", "the", "effects", "were", "additive", "."], "h": {"id": "C0719425", "name": "C0719425#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [6, 7]}}
{"token": ["Closure", "of", "the", "C3537143#ent", "<e1>", "was", "accomplished", "by", "esterification", "of", "the", "C24", "C0001975#ent", "<e2>", "followed", "by", "intramolecular", "Horner-Wadsworth-Emmons", "condensation", "to", "set", "the", "(E)-C2-C3", "alkene", "."], "h": {"id": "C3537143", "name": "C3537143#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [12, 13]}}
{"token": ["Other", "roles", "for", "echocardiography", "include", "differentiating", "left-", "and", "right-sided", "heart", "failure", "assessing", "the", "extent", "of", "C0265122#ent", "<e1>", "diagnosing", "disorders", "of", "the", "thoracic", "aorta", "and", "evaluating", "C0018799#ent", "<e2>"], "h": {"id": "C0265122", "name": "C0265122#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [25, 26]}}
{"token": ["FOG-1", "has", "also", "been", "observed", "to", "interact", "with", "the", "corepressor", "molecule", "C-terminal", "binding", "protein", "C1332799#ent", "<e1>", ")", "through", "a", "C0030956#ent", "<e2>", "by", "all", "FOG", "family", "members"], "h": {"id": "C1332799", "name": "C1332799#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}}
{"token": ["Full-length", "cellular", "APP", "is", "cleaved", "by", "C0171484#ent", "<e1>", "intracellularly", "in", "the", "Trans-Golgi", "Network", "C1420709#ent", "<e2>", ")", "or", "in", "post-Golgi", "vesicles"], "h": {"id": "C0171484", "name": "C0171484#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [13, 14]}}
{"token": ["In", "the", "presence", "of", "human", "C1515406#ent", "<e1>", "TGF-beta", "1", ")", "the", "capacity", "of", "C1366480#ent", "<e2>", "to", "augment", "the", "proliferative", "state", "of", "AML", "blasts", "was", ",", "however", ",", "almost", "completely", "abolished", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366480", "name": "C1366480#ent", "pos": [13, 14]}}
{"token": ["Intestinal", "trefoil", "factor", "C1420702#ent", "<e1>", ")", "from", "human", "(", "C0660409#ent", "<e2>", ")", "and", "rat", "(", "rITF", ")", "have", "been", "produced", "in", "Saccharomyces", "cerevisiae"], "h": {"id": "C1420702", "name": "C1420702#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0660409", "name": "C0660409#ent", "pos": [9, 10]}}
{"token": ["UFD1L", "is", "the", "human", "C1334043#ent", "<e1>", "of", "the", "yeast", "ubiquitin", "fusion", "degradation", "1", "C1421316#ent", "<e2>", ")", "gene", "and", "maps", "on", "chromosome", "22q11.2", "the", "typically", "deleted", "region", "(", "TDR", ")", "for", "DiGeorge/velocardiofacial", "syndromes", "DGS/VCFS", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421316", "name": "C1421316#ent", "pos": [13, 14]}}
{"token": ["The", "BDNF", "action", "appeared", "to", "be", "specific", ",", "since", "nerve", "growth", "factor", "another", "member", "of", "the", "C1334907#ent", "<e1>", "had", "no", "effect", "on", "C1415300#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C1334907", "name": "C1334907#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415300", "name": "C1415300#ent", "pos": [22, 23]}}
{"token": ["These", "disease/gene", "matches", "include", "the", "oculorenal", "syndrome", "PAX2", ";", "aniridia", "and", "PAX6", ";", "Rieger", "syndrome", "RIEG1/PITX2", ";", "cyclopia", "and", "Sonic", "hedgehog", "C4085590#ent", "<e1>", "Leber's", "congenital", "amaurosis", "CRX", ";", "and", "recessive", "septooptic", "dysplasia", "C1415521#ent", "<e2>", "."], "h": {"id": "C4085590", "name": "C4085590#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1415521", "name": "C1415521#ent", "pos": [32, 33]}}
{"token": ["DNA", "digestion", "best", "using", "pH", "5.0", "C0142785#ent", "<e1>", "a", "30", "min", "incubation", "with", "C1336670#ent", "<e2>", "phosphodiesterase", "II", "and", "a", "2", "h", "acid", "phosphatase", "digest"], "h": {"id": "C0142785", "name": "C0142785#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336670", "name": "C1336670#ent", "pos": [13, 14]}}
{"token": ["We", "have", "examined", "the", "effect", "of", "C0023992#ent", "<e1>", "on", "the", "hepatic", "metabolism", "biliary", "excretion", "C0594375#ent", "<e2>", "in", "the", "isolated", "perfused", "rat", "liver", "(", "IPRL", ")", "."], "h": {"id": "C0023992", "name": "C0023992#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [14, 15]}}
{"token": ["Every", "3-rd", "month", "of", "therapy", "we", "measured", "serum", "concentration", "of", "C1332773#ent", "<e1>", "carboxy-terminal", "propeptide", "PICP", "as", "a", "marker", "of", "bone", "formation", "well", "as", "C1173297#ent", "<e2>", "iPTH", "as", "markers", "of", "bone", "resorption"], "h": {"id": "C1332773", "name": "C1332773#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1173297", "name": "C1173297#ent", "pos": [23, 24]}}
{"token": ["Dipyridamole", "(", "C1419059#ent", "<e1>", ")", ",", "a", "clinically", "used", "C0042402#ent", "<e2>", "and", "an", "antiplatelet", "compound", ",", "augmented", "the", "activity", "of", "the", "anticancer", "drug", "mitoxantrone", "MXN", ")", "toward", "chinese", "hamster", "ovary", "CHO-K1", ")", "cells", "in", "culture", "."], "h": {"id": "C1419059", "name": "C1419059#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [9, 10]}}
{"token": ["Of", "several", "protein", "kinase", "inhibitors", "tested", ",", "only", "inhibitors", "of", "C0080054#ent", "<e1>", "cdk", ")", "activity", "(", "C0536217#ent", "<e2>", ",", "olomoucine", ")", "prevented", "passage", "through", "the", "ODP", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0536217", "name": "C0536217#ent", "pos": [16, 17]}}
{"token": ["ADPKD", "is", "caused", "by", "mutations", "in", "the", "C1418599#ent", "<e1>", "and", "PKD2", "genes", ",", "encoding", "the", "transmembrane", "proteins", "polycystin-1", "C3849253#ent", "<e2>", ")", "and", "polycystin-2", "(", "PC2", ")", ",", "respectively", "."], "h": {"id": "C1418599", "name": "C1418599#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3849253", "name": "C3849253#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "C1418599#ent", "<e1>", "and", "PKD2", ",", "which", "encode", "the", "transmembrane", "proteins", "polycystin-1", "C3849253#ent", "<e2>", ")", "and", "polycystin-2", "(", "PC2", ")", "respectively", ",", "account", "for", "almost", "all", "cases", "of", "ADPKD", "."], "h": {"id": "C1418599", "name": "C1418599#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3849253", "name": "C3849253#ent", "pos": [13, 14]}}
{"token": ["Primary", "cilia", "implicated", "in", "the", "pathogenesis", "of", "autosomal-dominant", "polycystic", "kidney", "disease", "ADPKD", ")", ",", "which", "results", "from", "defects", "in", "C1418599#ent", "<e1>", "(", "C3849253#ent", "<e2>", ")", ",", "but", "the", "function", "of", "C3849253#ent", "<e2>", "remains", "poorly", "understood", "."], "h": {"id": "C1418599", "name": "C1418599#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3849253", "name": "C3849253#ent", "pos": [22, 23]}}
{"token": ["C1414926#ent", "<e1>", "contains", "a", "motif", "that", "has", "a", "C0000608#ent", "<e2>", "with", "CBV-P2C", "(", "PEVKEK", ")", ",", "whereas", "the", "weakly", "autoantigenic", "isoform", ",", "GAD67", ",", "contains", "PEVKTK", "."], "h": {"id": "C1414926", "name": "C1414926#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000608", "name": "C0000608#ent", "pos": [8, 9]}}
{"token": ["All", "of", "them", "presented", "the", "typical", "C0037284#ent", "<e1>", "of", "papules", "and", "C0239377#ent", "<e2>", "erythematous", "--", "edematous", "plaques", "in", "face", ",", "neck", "and", "upper", "chest"], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [11, 12]}}
{"token": ["C0034422#ent", "<e1>", "well", "absorbed", "in", "uncomplicated", "falciparum", "C0024530#ent", "<e2>", "."], "h": {"id": "C0034422", "name": "C0034422#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [7, 8]}}
{"token": ["Concentrations", "of", "insulin-like", "growth", "factor-1", "IGF-I", ")", "and", "insulin-like", "growth", "factor", "binding", "proteins", "IGFBP", ")", "in", "FF", "and", "plasma", ",", "and", "C0003805#ent", "<e1>", "mRNA", "in", "granulosa", "cells", "similar", "for", "C0429468#ent", "<e2>", "and", "proestrous", "cows", "."], "h": {"id": "C0003805", "name": "C0003805#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0429468", "name": "C0429468#ent", "pos": [29, 30]}}
{"token": ["In", "normal", "cells", "C1704851#ent", "<e1>", "could", "contribute", "to", "suppressing", "C1705526#ent", "<e2>", "activation", "until", "its", "functions", "are", "absolutely", "required", "while", "in", "cancer", "cells", "overexpression", "of", "C1704851#ent", "<e1>", "could", "contribute", "to", "C1705526#ent", "<e2>", "inactivation", "and", "tumor", "progression"], "h": {"id": "C1704851", "name": "C1704851#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "C1704851#ent", "<e1>", "is", "a", "UV", "damage", "response", "protein", "undergoes", "nucleoplasmic", "redistribution", "and", "regulates", "C1705526#ent", "<e2>", "and", "HDM2", "levels", "and", "their", "interaction", "."], "h": {"id": "C1704851", "name": "C1704851#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [17, 18]}}
{"token": ["RSG", "has", "a", "higher", "affinity", "for", "C1418779#ent", "<e1>", "than", "troglitazone", "or", "C0872972#ent", "<e2>", "and", "the", "in", "vivo", "antidiabetic", "potency", "of", "RSG", "is", "correlated", "with", "its", "high", "biding", "affinity", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0872972", "name": "C0872972#ent", "pos": [11, 12]}}
{"token": ["Glial", "HA-binding", "protein", "(", "C3810548#ent", "<e1>", ")", "is", "probably", "a", "proteolytic", "product", "of", "C1413763#ent", "<e2>", "corresponding", "to", "its", "HA-binding", "amino-terminal", "domain"], "h": {"id": "C3810548", "name": "C3810548#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413763", "name": "C1413763#ent", "pos": [13, 14]}}
{"token": ["C4277608#ent", "<e1>", "of", "chick", "C1537580#ent", "<e2>", "exist", "in", "human", ",", "mouse", "and", "Drosophila", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537580", "name": "C1537580#ent", "pos": [4, 5]}}
{"token": ["The", "Com\u00e8l-Netherton", "syndrome", "an", "autosomal", "recessive", "multisystemic", "disorder", "by", "localized", "or", "C0079583#ent", "<e1>", "hair", "shaft", "abnormalities", "immune", "deficiency", "and", "markedly", "elevated", "C1415975#ent", "<e2>", "levels", "."], "h": {"id": "C0079583", "name": "C0079583#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [21, 22]}}
{"token": ["The", "inotropic", "effectiveness", "the", "beta-adrenergic", "agonist", "C0282210#ent", "<e1>", "and", "the", "phosphodiesterase", "inhibitors", "C0128513#ent", "<e2>", ",", "caffeine", ",", "and", "isobutylmethylxanthine", "was", "markedly", "reduced", "in", "muscles", "from", "the", "patients", "with", "heart", "failure"], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0128513", "name": "C0128513#ent", "pos": [12, 13]}}
{"token": ["Directly", "elicited", "twitch", "tension", "increased", "by", "aminophylline", ",", "forskolin", ",", "and", "C0282210#ent", "<e1>", "but", "was", "not", "altered", "by", "C0128513#ent", "<e2>", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0128513", "name": "C0128513#ent", "pos": [18, 19]}}
{"token": ["C0039263#ent", "<e1>", "TA", ")", "is", "a", "C0042384#ent", "<e2>", "causes", "stenosis", "or", "occlusion", ",", "rarely", "aneurysm", "and", "distal", "ischemia"], "h": {"id": "C0039263", "name": "C0039263#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [6, 7]}}
{"token": ["The", "gene", "responsible", "for", "C1418270#ent", "<e1>", "was", "recently", "identified", "and", "designated", "C1418270#ent", "<e1>", "."], "h": {"id": "C1418270", "name": "C1418270#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [4, 5]}}
{"token": ["Prostacyclin", "(", "PGI(2", ")", ")", "is", "a", "labile", ",", "lipid-derived", "metabolite", "of", "arachidonic", "acid", "synthesized", "through", "the", "sequential", "action", "of", "C0033551#ent", "<e1>", "(", "COX", ")", "and", "prostacyclin", "synthase", "C3272780#ent", "<e2>", ")", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3272780", "name": "C3272780#ent", "pos": [28, 29]}}
{"token": ["The", "priming", "activity", "the", "C0035681#ent", "<e1>", "be", "taken", "over", "by", "C0058594#ent", "<e2>", "later", ",", "which", "seems", "to", "be", "a", "specialized", "RNA", "polymerase", "abortive", "cycling", "."], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0058594", "name": "C0058594#ent", "pos": [10, 11]}}
{"token": ["In", "cardiac", "IPC", ",", "pertussis", "toxin-sensitive", "G-proteins", "(", "i.e.", ",", "G(i/o", ")", ")", ",", "C0033634#ent", "<e1>", "PKC", ")", ",", "and", "C1955862#ent", "<e2>", "K+(ATP", ")", ")", "channels", "are", "implicated", "in", "this", "protective", "signaling", "pathway"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1955862", "name": "C1955862#ent", "pos": [20, 21]}}
{"token": ["Activators", "of", "C0033634#ent", "<e1>", "a", "diacylglycerol", "analogue", "and", "phorbol", "12-myristate", "13-acetate", "PMA", ")", ",", "inhibited", "C1955862#ent", "<e2>", "currents", "by", "87.3", "and", "84.2", "%", ",", "respectively", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1955862", "name": "C1955862#ent", "pos": [15, 16]}}
{"token": ["Arterial", "smooth", "muscle", "expressed", "messengers", "for", "Kv1.2", ",", "Kv1.3", ",", "C1416547#ent", "<e1>", ",", "Kv1.5", "and", "C1416549#ent", "<e2>", ",", "and", "proteins", "of", "Kv1.1", ",", "Kv1.2", "and", "C1416547#ent", "<e1>", "."], "h": {"id": "C1416549", "name": "C1416549#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1416547", "name": "C1416547#ent", "pos": [10, 11]}}
{"token": ["We", "further", "showed", "that", "LOXL1", "and", "C1424794#ent", "<e1>", "are", "commonly", "silenced", "C0017337#ent", "<e2>", "in", "human", "bladder", "cancer", "cells", "and", "this", "silence", "is", "predominantly", "related", "to", "promoter", "methylation"], "h": {"id": "C1424794", "name": "C1424794#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["The", "C0597094#ent", "<e1>", "did", "not", "have", "an", "absolute", "requirement", "for", "C1417500#ent", "<e2>", "+", "."], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [10, 11]}}
{"token": ["The", "changes", "for", "the", "C1826536#ent", "<e1>", "values", "comparing", "the", "controls", "and", "the", "tissues", "incubated", "with", "C0022616#ent", "<e2>", "were", "statistically", "significant", "P", "<", "0.05", ")", "."], "h": {"id": "C1826536", "name": "C1826536#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [15, 16]}}
{"token": ["We", "propose", "that", ",", "in", "vivo", "C1449330#ent", "<e1>", "may", "colocalize", "the", "C0031727#ent", "<e2>", "with", "its", "PH", "domain-containing", "substrates"], "h": {"id": "C1449330", "name": "C1449330#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["We", "identified", "C1449330#ent", "<e1>", ",", "a", "receptor", "for", "activated", "C0031727#ent", "<e2>", "a", "homolog", "of", "the", "beta", "subunit", "G", "proteins", "as", "a", "Src-binding", "protein", "."], "h": {"id": "C1449330", "name": "C1449330#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}}
{"token": ["Addition", "of", "an", "appropriate", "C0879590#ent", "<e1>", "second", "messenger", "C2987634#ent", "<e2>", "at", "the", "time", "of", "serum", "withdrawal", "or", "within", "2", "h", "after", "serum", "withdrawal", "protects", "a", "similar", "fraction", "of", "viable", "cells"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}}
{"token": ["In", "assays", "of", "C0879590#ent", "<e1>", "production", ",", "RMBP", "was", "a", "partial", "C2987634#ent", "<e2>", "that", "stimulated", "an", "intermediate", "level", "C0879590#ent", "<e1>", "production", "but", "antagonized", "high", "levels", "of", "GPMBP-stimulated", "C0879590#ent", "<e1>", "production", "to", "that", "intermediate", "level"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "TH", "was", "effective", "in", "modulating", "both", "C0669365#ent", "<e1>", "and", "inducible", "C1428159#ent", "<e2>", "gene", "expression", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1428159", "name": "C1428159#ent", "pos": [12, 13]}}
{"token": ["1-Azabicyclo[2,2,2]octane,3-(6-chloropyrazinyl)maleate", "(", "C0171489#ent", "<e1>", ")", "reportedly", "is", "an", "C2987634#ent", "<e2>", "with", "selectivity", "for", "M1", "and", "M3", "muscarinic", "receptors"], "h": {"id": "C0171489", "name": "C0171489#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}}
{"token": ["Thus", ",", "with", "functional", "assays", "either", "with", "brain", "tissue", "with", "transfected", "cell", "lines", ",", "C0171489#ent", "<e1>", "was", "shown", "to", "be", "an", "C2987634#ent", "<e2>", "for", "the", "M1", "and", "M3", "receptors", "not", "for", "M5", "or", "M4", "receptors"], "h": {"id": "C0171489", "name": "C0171489#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [21, 22]}}
{"token": ["They", "may", "be", "present", "in", "C1334156#ent", "<e1>", "deep", "mycoses", "and", "other", "C0005943#ent", "<e2>"], "h": {"id": "C1334156", "name": "C1334156#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [11, 12]}}
{"token": ["Stress", "and", "depression", "also", "have", "been", "associated", "with", "outcomes", "in", "C1334156#ent", "<e1>", "cancer", "and", "C0005943#ent", "<e2>", "that", "stress/depression", "effects", "on", "the", "immune", "system", "clinically", "relevant", "to", "disease", "expression"], "h": {"id": "C1334156", "name": "C1334156#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [14, 15]}}
{"token": ["Perturbations", "of", "these", "systems", "are", "found", "in", "C0007682#ent", "<e1>", "associated", "with", ",", "such", "as", "stroke", ",", "Parkinson's", "disease", "spinal", "cord", "injury", "C0026769#ent", "<e2>"], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [21, 22]}}
{"token": ["Of", "34", "patients", "with", "C0007682#ent", "<e1>", "three", "with", "C0026769#ent", "<e2>", "two", "with", "stroke", "gave", "similar", "results", "."], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "indicate", "that", "Msh2-mediated", "apoptosis", "is", "an", "important", "component", "of", "tumor", "suppression", "that", "certain", "C0879290#ent", "<e1>", "missense", "mutations", "cause", "mismatch", "repair", "deficiency", "retaining", "the", "signaling", "functions", "confer", "sensitivity", "to", "C0729502#ent", "<e2>"], "h": {"id": "C0879290", "name": "C0879290#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [30, 31]}}
{"token": ["However", ",", "protein", "surfaces", "contain", "\"", "C0263214#ent", "<e1>", "\"", "small", "patches", "are", "the", "main", "C0127400#ent", "<e2>", "of", "binding", "affinity", "."], "h": {"id": "C0263214", "name": "C0263214#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "function", "of", "C3540579#ent", "<e1>", ",", "deletions", "of", "the", "C1412821#ent", "<e2>", "made", "in", "a", "wild-type", "strain", "and", "a", "strain", "deficient", "the", "known", "yeast", "AP", "endonuclease", "encoded", "by", "APN1", "."], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "C0027719#ent", "<e1>", "is", "usually", "associated", "with", "diseases", "such", "as", "C0011847#ent", "<e2>", ",", "high", "blood", "cholesterol", "and", "hypertension", "."], "h": {"id": "C0027719", "name": "C0027719#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [12, 13]}}
{"token": ["The", "cause", "of", "C0033775#ent", "<e1>", "can", "be", "as", "benign", "as", "C0720057#ent", "<e2>", "as", "serious", "as", "liver", "disease"], "h": {"id": "C0033775", "name": "C0033775#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0720057", "name": "C0720057#ent", "pos": [10, 11]}}
{"token": ["The", "variant", "form", "of", "late", "infantile", "neuronal", "ceroid", "lipofuscinosis", "vLINCL", ",", "locus", "definition", "C1413497#ent", "<e1>", ")", "represents", "a", "progressive", "brain", "disease", "C3899988#ent", "<e2>", "inheritance", "."], "h": {"id": "C1413497", "name": "C1413497#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [21, 22]}}
{"token": ["S.", "enteritidis", "associated", "with", "epithelial", "surface", "of", "the", "C1421450#ent", "<e1>", "in", "the", "low-dose", "group", "C0044222#ent", "<e2>", "d", "pi", ",", "the", "penetration", "in", "the", "cecal", "lamina", "propria", "was", "observed", "on", "day", "1", "and", "10", "pi", "."], "h": {"id": "C1421450", "name": "C1421450#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0044222", "name": "C0044222#ent", "pos": [14, 15]}}
{"token": ["C1367714#ent", "<e1>", "partially", "displaced", "[(125)I]Trp-Lys-Tyr-Met-Val-d-Met-NH(2", ")", "(", "C0755643#ent", "<e2>", ")", "binding", "to", "FPRL1", "but", "not", "[(3)H]N-formyl-Met-Leu-Phe", "to", "formyl", "peptide", "receptor"], "h": {"id": "C1367714", "name": "C1367714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0755643", "name": "C0755643#ent", "pos": [7, 8]}}
{"token": ["Other", "C0740451#ent", "<e1>", "the", "GI", "tract", "like", "tuberculosis", ",", "fungal", "infections", "parasitic", "diseases", "inflammatory", "bowel", "disease", "and", "C0023788#ent", "<e2>", "should", "be", "excluded", "before", "making", "the", "diagnosis", "of", "GI", "sarcoidosis"], "h": {"id": "C0740451", "name": "C0740451#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023788", "name": "C0023788#ent", "pos": [17, 18]}}
{"token": ["The", "results", "showed", "that", "the", "toxic", "effect", "HDTMAB", "on", "Alexandrium", "sp.", "C3540600#ent", "<e1>", "was", "significantly", "reduced", "in", "the", "presence", "of", "C1413043#ent", "<e2>", ",", "especially", "under", "4", "mmol/L", "of", "C1413043#ent", "<e2>", "+", "."], "h": {"id": "C3540600", "name": "C3540600#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [20, 21]}}
{"token": ["Conversely", ",", "when", "treated", "with", "vanadate", "(", "a", "C1335554#ent", "<e1>", "inhibitor", ")", ",", "the", "C0085536#ent", "<e2>", "content", "of", "PDPK", "F(A)/GSK-3alpha", "in", "LNCaP", "cells", "can", "be", "promoted", "to", "the", "level", "of", "PC-3", "cells"], "h": {"id": "C1335554", "name": "C1335554#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [14, 15]}}
{"token": ["When", "the", "cultured", "chromaffin", "cells", "treated", "for", "72", "h", "with", "N-acetylserotonin", ",", "an", "inhibitor", "of", "C0074350#ent", "<e1>", "tetrahydrobiopterin", "content", "and", "the", "rate", "of", "C0041491#ent", "<e2>", "decreased", "."], "h": {"id": "C0074350", "name": "C0074350#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041491", "name": "C0041491#ent", "pos": [23, 24]}}
{"token": ["Menkes'", "C0022716#ent", "<e1>", "MKHS", ")", "comprises", "an", "array", "of", "clinical", "manifestations", "hair", "shaft", "abnormalities", "C0162835#ent", "<e2>", "and", "progressive", "cerebral", "degeneration", "are", "transmitted", "as", "an", "X-linked", "recessive", "disorder", "copper", "transport", "pathways", "primarily", "young", "males", "."], "h": {"id": "C0022716", "name": "C0022716#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0162835", "name": "C0162835#ent", "pos": [14, 15]}}
{"token": ["TSH", "receptor", "(", "C1336679#ent", "<e1>", ")", "is", "a", "member", "of", "the", "C1537570#ent", "<e2>"], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1537570", "name": "C1537570#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "to", "investigate", "whether", "smoking", "acts", "as", "a", "C0442893#ent", "<e1>", "to", "see", "if", "there", "is", "a", "relation", "between", "C1826658#ent", "<e2>", "values", "and", "smoking", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1826658", "name": "C1826658#ent", "pos": [20, 21]}}
{"token": ["Homosexual", "and", "bisexual", "white", "men", "with", "C0041976#ent", "<e1>", "were", "more", "likely", "to", "have", "gonorrhea", ",", "whereas", "heterosexual", "white", "men", "with", "C0041976#ent", "<e1>", "were", "more", "likely", "to", "have", "C0018078#ent", "<e1>"], "h": {"id": "C0041976", "name": "C0041976#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0018078", "name": "C0018078#ent", "pos": [27, 28]}}
{"token": ["In", "pancreatic", "juice", "C0108101#ent", "<e1>", "precipitation", "is", "prevented", "by", "lithostathine", ",", "a", "C0072522#ent", "<e2>", "that", "inhibits", "C0108101#ent", "<e1>", "crystal", "growth"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0108101", "name": "C0108101#ent", "pos": [3, 4]}}
{"token": ["We", "genetically", "screened", "patients", "with", "ataxia", "with", "C3489733#ent", "<e1>", "ataxia", "with", "ocular", "motor", "apraxia", "hypoalbuminemia", "(", "C1859598#ent", "<e2>", ")", ",", "with", "a", "Japanese", "variant", "form", "of", "Friedreich's", "ataxia"], "h": {"id": "C3489733", "name": "C3489733#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C1859598", "name": "C1859598#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "nylestriol", "is", "a", "convenient", "and", "acceptable", "C0013227#ent", "<e1>", "which", "was", "beneficial", "for", "relieving", "C0025319#ent", "<e2>", "preventing", "osteoporosis", "and", "improving", "lipoprotein", "lipid", "pattern"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025319", "name": "C0025319#ent", "pos": [16, 17]}}
{"token": ["This", "agent", "'s", "capacity", "to", "relieve", "vasomotor", "instability", "improve", "vaginal", "maturation", "notable", "side", "effects", "sufficient", "reason", "to", "include", "this", "C0013227#ent", "<e1>", "in", "the", "management", "of", "the", "C0025319#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0025319", "name": "C0025319#ent", "pos": [26, 27]}}
{"token": ["Two", "of", "these", "C1305923#ent", "<e1>", "were", "identified", "as", "RepA1", "and", "C3889265#ent", "<e2>", ",", "proteins", "encoded", "by", "the", "essential", "replication", "region", "pSM1/R100", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889265", "name": "C3889265#ent", "pos": [10, 11]}}
{"token": ["Post-training", "intra-hippocampal", "infusions", "of", "C0006400#ent", "<e1>", "attenuated", "acquisition", "of", "the", "place", "C1416596#ent", "<e2>", "and", "enhanced", "acquisition", "of", "the", "response", "task", "."], "h": {"id": "C0006400", "name": "C0006400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [11, 12]}}
{"token": ["The", "CH(2)Cl(2)/CH(3)OH", "extract", "of", "Kalanchoe", "crenata", "increased", "the", "latency", "period", "in", "seizures", "induced", "by", "PTZ", "and", "significantly", "reduced", "the", "C2926735#ent", "<e1>", "of", "seizures", "induced", "by", "the", "three", "C0003286#ent", "<e2>"], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [27, 28]}}
{"token": ["The", "stress-inducible", "gene", "product", "C0018969#ent", "<e1>", "and", "carbon", "monoxide", "CO", ")", ",", "a", "major", "by-product", "of", "C0018969#ent", "<e1>", "heme", ",", "have", "been", "shown", "to", "confer", "potent", "antiinflammatory", "effects", "models", "of", "tissue", "and", "cellular", "injury"], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018969", "name": "C0018969#ent", "pos": [4, 5]}}
{"token": ["Other", "unusual", "features", "of", "this", "case", "were", "the", "young", "age", "(", "20", "C1710700#ent", "<e1>", ")", "of", "the", "patient", "and", "absence", "of", "any", "C1457887#ent", "<e2>"], "h": {"id": "C1710700", "name": "C1710700#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [22, 23]}}
{"token": ["Our", "results", "show", "that", "the", "structural", "ribosomal", "protein", "S20", "(", "C1336986#ent", "<e1>", ")", "and", "the", "translation", "elongation", "factor", "1alpha", "C1705443#ent", "<e2>", ")", "are", "valid", "as", "reference", "genes", "less", "than", "two", "fold", "variation", "in", "transcript", "levels", "."], "h": {"id": "C1336986", "name": "C1336986#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705443", "name": "C1705443#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "show", "that", "C0907533#ent", "<e1>", "processing", "of", "C1540205#ent", "<e2>", "also", "requires", "IKKalpha", ",", "but", "not", "IKKbeta", "(", "IkappaB", "kinase", "beta", "or", "IKKgamma", "(", "IkappaB", "kinase", "gamma", ")", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1540205", "name": "C1540205#ent", "pos": [9, 10]}}
{"token": ["When", "acyl-CoA", "synthetase", "which", "catalyzes", "the", "conversion", "of", "fatty", "acids", "fatty", "acyl-CoA", "was", "inhibited", "with", "C0076992#ent", "<e1>", "the", "increases", "in", "both", "AMPK", "activity", "and", "C4084937#ent", "<e2>", ":", "ATP", "ratio", "were", "blunted", "."], "h": {"id": "C0076992", "name": "C0076992#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4084937", "name": "C4084937#ent", "pos": [24, 25]}}
{"token": ["The", "presence", "of", "taxol", "in", "the", "culture", "medium", "the", "effects", "of", "C0050565#ent", "<e1>", "on", "NO", "production", "and", "C0669365#ent", "<e2>", "activity", "in", "PAEC", "."], "h": {"id": "C0050565", "name": "C0050565#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "KB", "cells", "microtubule-disrupting", "agents", ",", "like", "colchicine", ",", "C0050565#ent", "<e1>", "and", "vinblastine", ",", "potentiated", "the", "C0669365#ent", "<e2>", "and", "cytokine-induced", "ICAM-1", "expression", "on", "the", "cell", "surface"], "h": {"id": "C0050565", "name": "C0050565#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}}
{"token": ["Collectively", ",", "the", "results", "provide", "evidence", "for", "a", "potential", "role", "of", "multiple", "predicted", "C3542399#ent", "<e1>", "isoforms", "in", "the", "C1710463#ent", "<e2>", "the", "ASNS", "gene", "response", "to", "nutrient", "deprivation", "."], "h": {"id": "C3542399", "name": "C3542399#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "C0483249#ent", "<e1>", "be", "useful", "as", "a", "new", "stand-alone", "therapy", "for", "C0038454#ent", "<e2>", "to", "extend", "the", "time", "window", "thrombolytic", "therapy"], "h": {"id": "C0483249", "name": "C0483249#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [12, 13]}}
{"token": ["The", "activities", "and", "hormonal", "regulations", "C1413745#ent", "<e1>", "CS", ")", "and", "phosphoenolpyruvate", "carboxykinase", "C0031644#ent", "<e2>", ")", "in", "the", "liver", "of", "male", "rats", "of", "various", "ages", "were", "studied", "."], "h": {"id": "C1413745", "name": "C1413745#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [12, 13]}}
{"token": ["Chondroadherin", "(", "the", "C1826560#ent", "<e1>", "is", "a", "leucine-rich", ",", "C1417041#ent", "<e2>", "to", "mediate", "adhesion", "of", "isolated", "chondrocytes", "."], "h": {"id": "C1826560", "name": "C1826560#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417041", "name": "C1417041#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "IFN-gamma", ",", "IL-2", "and", "TNF-alpha", "inhibited", "the", "ability", "of", "thyroid", "lymphocytes", "patients", "with", "Graves'", "disease", "C0342124#ent", "<e1>", "synthesize", "autoantibodies", "to", "C0021965#ent", "<e2>", "TPO", ")", "and", "thyroglobulin", "(", "Tg", ")", "."], "h": {"id": "C0342124", "name": "C0342124#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0021965", "name": "C0021965#ent", "pos": [23, 24]}}
{"token": ["Our", "data", "suggest", "that", "cytotoxicity", "in", "sera", "from", "patients", "with", "C0342124#ent", "<e1>", "not", "mediated", "by", "antibodies", "against", "C0021965#ent", "<e2>", "but", "by", "antibodies", "not", "yet", "identified", "."], "h": {"id": "C0342124", "name": "C0342124#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021965", "name": "C0021965#ent", "pos": [17, 18]}}
{"token": ["Important", "downstream", "targets", "include", "C0949684#ent", "<e1>", "actin", "capping", "severing", "proteins", ",", "formins", ",", "C0072074#ent", "<e2>", ",", "cofilin", ",", "and", "the", "actin-related", "protein-2/3", "complex"], "h": {"id": "C0949684", "name": "C0949684#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072074", "name": "C0072074#ent", "pos": [13, 14]}}
{"token": ["It", "has", "been", "demonstrated", "that", "enzymes", "from", "Clostridium", "thermoaceticum", "the", "following", "reaction", "in", "which", "Fd", "is", "C1414571#ent", "<e1>", "and", "CH3THF", "is", "C2939773#ent", "<e2>", "."], "h": {"id": "C1414571", "name": "C1414571#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2939773", "name": "C2939773#ent", "pos": [21, 22]}}
{"token": ["Consequently", ",", "C3274756#ent", "<e1>", "suppressed", "phosphorylation", "of", "IkappaB", "kinase", "alpha/beta", "IKKalpha/beta", ")", "and", "TGF-beta-activated", "kinase", "C3812805#ent", "<e2>", ")", "."], "h": {"id": "C3274756", "name": "C3274756#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3812805", "name": "C3812805#ent", "pos": [15, 16]}}
{"token": ["C0520739#ent", "<e1>", "had", "a", "deleterious", "effects", "tissue", "structure", "C0022672#ent", "<e2>", "and", "induced", "an", "increase", "in", "catalase", "(", "Cat", ")", "and", "a", "decrease", "in", "manganese", "superoxide", "dismutase", "Mn", "SOD", ")", "and", "gluthatione", "peroxidase", "GPx", ")", "activity", "."], "h": {"id": "C0520739", "name": "C0520739#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022672", "name": "C0022672#ent", "pos": [8, 9]}}
{"token": ["The", "soluble", "and", "reconstituted", "protein", "a", "homogeneous", "[3H]flunitrazepam", "binding", "population", "and", "the", "allosteric", "modulation", "this", "binding", "site", "GABA", ",", "by", "the", "pyrazolopyridine", ",", "C0054831#ent", "<e1>", ",", "and", "by", "the", "depressant", "barbiturate", "C0030883#ent", "<e2>", "."], "h": {"id": "C0054831", "name": "C0054831#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [31, 32]}}
{"token": ["A", "positive", "feedback", "model", "that", "calcium", "released", "during", "a", "conditioning", "pulse", "C1418824#ent", "<e1>", ")", "facilitates", "the", "subsequent", "pulse", "(", "I2", ")", "via", "C0006776#ent", "<e2>", "CaMKII", ")", "mechanisms", "."], "h": {"id": "C1418824", "name": "C1418824#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006776", "name": "C0006776#ent", "pos": [22, 23]}}
{"token": ["The", "C0003374#ent", "<e1>", "chloroquine", "and", "C0020336#ent", "<e2>", ",", "are", "some", "of", "the", "most", "commonly", "used", "DMARDs", "in", "the", "management", "of", "RA", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0020336", "name": "C0020336#ent", "pos": [5, 6]}}
{"token": ["The", "second", "condition", "is", "explained", "by", "an", "impairment", "of", "the", "molecular", "control", "axon", "growth", "such", "is", "the", "case", "for", "the", "couple", "netrin", "1", "C1704789#ent", "<e1>", "or", "for", "the", "C1416769#ent", "<e2>"], "h": {"id": "C1704789", "name": "C1704789#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1416769", "name": "C1416769#ent", "pos": [28, 29]}}
{"token": ["Targeted", "disruption", "of", "Hoxa11", "and", "C1415685#ent", "<e1>", "or", "Hoxa10", ",", "Hoxc10", "and", "C3273504#ent", "<e2>", "result", "in", "gross", "mispatterning", "of", "the", "radius", "and", "ulna", "or", "the", "femur", ",", "respectively", "."], "h": {"id": "C1415685", "name": "C1415685#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273504", "name": "C3273504#ent", "pos": [12, 13]}}
{"token": ["C0003289#ent", "<e1>", "desipramine", ",", "imipramine", ",", "clomipramine", ",", "amitriptyline", "and", "C0013085#ent", "<e2>", ")", "had", "marked", "affinity", "for", "alpha-adrenergic", ",", "muscarinic", "cholinergic", "and", "histaminergic", "H1", "receptors", "and", "lesser", "affinity", "serotonin", "and", "dopamine", "receptors"], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [0, 1]}, "relation": "therapeutic_class_of", "t": {"id": "C0013085", "name": "C0013085#ent", "pos": [10, 11]}}
{"token": ["Finally", ",", "coimmunoprecipitation", "experiments", "(", "C3889135#ent", "<e1>", "immunoprecipitation", "followed", "by", "Western", "blot", "analysis", "C1414461#ent", "<e2>", "in", "the", "immunoprecipitate", ")", "produced", "definite", "evidence", "that", "C3889135#ent", "<e1>", "interacts", "with", "C1414461#ent", "<e2>", "."], "h": {"id": "C1414461", "name": "C1414461#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3889135", "name": "C3889135#ent", "pos": [5, 6]}}
{"token": ["It", "is", "capable", "of", "preventing", "the", "interaction", "of", "the", "transitional", "cells", "many", "substances", "in", "urine", ",", "including", "bacteria", ",", "C2936886#ent", "<e1>", ",", "protein", ",", "and", "potential", "C0085169#ent", "<e2>", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0085169", "name": "C0085169#ent", "pos": [26, 27]}}
{"token": ["We", "conclude", "that", "the", "phosphorylation", "site", "in", "C1439341#ent", "<e1>", "is", "a", "substrate", "for", "a", "Golgi", "membrane", "kinase", "that", "a", "similar", "C0027203#ent", "<e2>", "might", "act", "on", "endogenous", "C1439341#ent", "<e1>", "in", "vivo"], "h": {"id": "C1439341", "name": "C1439341#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [20, 21]}}
{"token": ["Three", "members", "of", "the", "ADAMTS", "family", "of", "proteinases", ",", "C1307941#ent", "<e1>", ",", "ADAMTS-4", "and", "ADAMTS-5", ",", "have", "been", "identified", "as", "C4255122#ent", "<e2>", "."], "h": {"id": "C1307941", "name": "C1307941#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4255122", "name": "C4255122#ent", "pos": [20, 21]}}
{"token": ["Serine", "proteases", "as", "thrombin", ",", "mast", "cell", "tryptase", "trypsin", ",", "or", "C1413814#ent", "<e1>", "for", "example", ",", "are", "highly", "C0127400#ent", "<e2>", "diverse", "biological", "activities"], "h": {"id": "C1413814", "name": "C1413814#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [18, 19]}}
{"token": ["One", "of", "these", "probably", "encodes", "C0070810#ent", "<e1>", "and", "two", "others", "are", "C1512488#ent", "<e2>", "to", "two", "of", "the", "three", "genes", "of", "the", "gerA", "and", "gerB", "loci", "(", "spore", "germination", "from", "Bacillus", "subtilis"], "h": {"id": "C0070810", "name": "C0070810#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}}
{"token": ["While", "upper", "reproductive", "tract", "anomalies", "have", "not", "been", "reported", "with", "MKS", ",", "they", "have", "been", "reported", "with", "C0752166#ent", "<e1>", "BBS", ")", ",", "a", "C0039082#ent", "<e2>", "that", "significantly", "overlaps", "with", "MKS", "."], "h": {"id": "C0752166", "name": "C0752166#ent", "pos": [17, 18]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [23, 24]}}
{"token": ["In", "a", "few", "cases", "of", "PPGSS", ",", "other", "C0042769#ent", "<e1>", "been", "found", ",", "for", "example", "hepatitis", "B", "C0025007#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0025007", "name": "C0025007#ent", "pos": [17, 18]}}
{"token": ["Serological", "evidence", "of", "C0042769#ent", "<e1>", "been", "detected", "among", "people", "exposed", "to", "C0025007#ent", "<e2>", "who", "do", "not", "exhibit", "classical", "clinical", "symptoms"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0025007", "name": "C0025007#ent", "pos": [11, 12]}}
{"token": ["Chemical", "modification", "studies", "site-directed", "mutagenesis", "experiments", "have", "provided", "evidence", "that", "human", "lysosomal", "acid", "lipase/cholesteryl", "ester", "hydrolase", "HLAL", ")", ",", "human", "gastric", "lipase", "C1367656#ent", "<e1>", ")", ",", "and", "rat", "lingual", "lipase", "RLL", ")", "are", "C1413347#ent", "<e2>"], "h": {"id": "C1367656", "name": "C1367656#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1413347", "name": "C1413347#ent", "pos": [33, 34]}}
{"token": ["To", "identify", "this", "C1367656#ent", "<e1>", "RNA", "was", "isolated", "from", "HL-60", "cells", "on", "bone", "marrow", "matrix", "assayed", "by", "Northern", "analysis", "expression", "of", "mRNA", "for", "human", "C1367656#ent", "<e1>", "tumor", "necrosis", "factor", "and", "macrophage", "colony-stimulating", "factor", "all", "inducers", "of", "C1413347#ent", "<e1>", "differentiation", "."], "h": {"id": "C1367656", "name": "C1367656#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413347", "name": "C1413347#ent", "pos": [36, 37]}}
{"token": ["Both", "cases", "involved", "anesthesiologists", "who", "took", "the", "C0012792#ent", "<e1>", "Sukolin", ")", "or", "C0071102#ent", "<e2>", "Arduan", ")", "and", "a", "rapid-acting", "barbiturate", ",", "5-sec-butyl-5-ethyl-2-thiobarbituric", "acid", "Inactin", ")", "."], "h": {"id": "C0012792", "name": "C0012792#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0071102", "name": "C0071102#ent", "pos": [12, 13]}}
{"token": ["Extracts", "of", "their", "total", "C0720831#ent", "<e1>", "population", "contained", "multiple", "small", "2", "-", "4", "kDa", ")", "C1136254#ent", "<e2>", "peptides", "."], "h": {"id": "C0720831", "name": "C0720831#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [15, 16]}}
{"token": ["Japan", "is", "one", "of", "a", "small", "number", "of", "countries", "to", "have", "successfully", "controlled", "or", "eliminated", "major", "C0747256#ent", "<e1>", "including", "malaria", ",", "C0016085#ent", "<e2>", ",", "schistosomiasis", "and", "enteric", "parasitoses", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0016085", "name": "C0016085#ent", "pos": [21, 22]}}
{"token": ["To", "evaluate", "long-term", "effects", ",", "we", "investigated", "the", "persistence", ",", "aggravation", "or", "disappearance", "of", "C0014868#ent", "<e1>", "patients", "with", "morbid", "obesity", "C0677659#ent", "<e2>", "diagnosed", "by", "endoscopic", "biopsy", "after", "Roux-en-Y", "gastric", "bypass"], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0677659", "name": "C0677659#ent", "pos": [20, 21]}}
{"token": ["Central", "ANG", "II", "stimulates", "swallowing", ",", "and", "nonspecific", "C2936804#ent", "<e1>", "inhibit", "both", "spontaneous", "and", "C1367482#ent", "<e2>", "II-stimulated", "swallowing", "."], "h": {"id": "C2936804", "name": "C2936804#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1367482", "name": "C1367482#ent", "pos": [14, 15]}}
{"token": ["The", "internal", "loop", "adopts", "a", "unique", "fold", "with", "the", "purine", "ring", "C4285220#ent", "<e1>", "intercalated", "between", "A10", "and", "C3538702#ent", "<e2>", "in", "the", "complex", "."], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538702", "name": "C3538702#ent", "pos": [17, 18]}}
{"token": ["The", "C1522419#ent", "<e1>", "P450c21", ")", "is", "a", "member", "of", "the", "C1333195#ent", "<e2>", "is", "essential", "in", "the", "synthesis", "of", "cortisol", "and", "aldosterone", "."], "h": {"id": "C1522419", "name": "C1522419#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333195", "name": "C1333195#ent", "pos": [10, 11]}}
{"token": ["Cyanopindolol", "antagonized", "isoprenaline-induced", "relaxation", "(", "in", "the", "presence", "of", "C0033497#ent", "<e1>", ",", "10(-7", ")", "M", ")", "with", "a", "C1839576#ent", "<e2>", "value", "of", "8.06", "+", "/-", "0.24", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [18, 19]}}
{"token": ["The", "objective", "of", "our", "study", "was", "to", "assess", "the", "gene", "expression", "the", "antiproliferative", "systems", "C0669368#ent", "<e1>", "nNOS", ")", "and", "C1412244#ent", "<e2>", "(", "AM", ")", "in", "human", "neuroblastoma", "."], "h": {"id": "C0669368", "name": "C0669368#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412244", "name": "C1412244#ent", "pos": [19, 20]}}
{"token": ["The", "C3275243#ent", "<e1>", "encoded", "by", "these", "cDNAs", "include", "a", "cell", "surface", "transporter", "secreted", "proteins", "a", "C0030946#ent", "<e2>", ",", "a", "protease", "inhibitor", "an", "RNA-binding", "protein", "a", "phosphatase", "inhibitor", "several", "enzymes", "."], "h": {"id": "C3275243", "name": "C3275243#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [15, 16]}}
{"token": ["Both", "C3275243#ent", "<e1>", "a", "hydrophobic", "leader", "peptide", "and", "putative", "recognition", "sites", "furin-like", "and", "PC-like", "C0030946#ent", "<e2>", "."], "h": {"id": "C3275243", "name": "C3275243#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [14, 15]}}
{"token": ["Sibrafiban", "(", "C2987048#ent", "<e1>", "48", "-", "3657", ")", "is", "an", "oral", ",", "C2936235#ent", "<e2>", ",", "selective", "antagonist", "of", "the", "glycoprotein", "IIb/IIIa", "receptor"], "h": {"id": "C2987048", "name": "C2987048#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936235", "name": "C2936235#ent", "pos": [12, 13]}}
{"token": ["Western", "blot", "analysis", "cell", "extracts", "that", "murine", "megakaryocyte", "and", "platelet", "antigens", "C0072522#ent", "<e1>", "(", "GP", ")", "IIb/IIIa", ",", "fibronectin", ",", "and", "factor", "VIII", "C1842325#ent", "<e2>", "were", "expressed", "in", "L8057", "cells", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1842325", "name": "C1842325#ent", "pos": [23, 24]}}
{"token": ["C3273629#ent", "<e1>", "BCL9", "and", "BCL9L", "are", "human", "homologs", "for", "Drosophila", "C1332402#ent", "<e2>", "."], "h": {"id": "C3273629", "name": "C3273629#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332402", "name": "C1332402#ent", "pos": [10, 11]}}
{"token": ["Mutation", "of", "the", "phosphorylation", "site", "Thr196", ")", "in", "CaM-KIV", ",", "which", "mediates", "its", "activation", "by", "C0248868#ent", "<e1>", "prevented", "activation", "of", "Elk-1", ",", "C0162508#ent", "<e2>", ",", "and", "ATF2", "by", "the", "CaM", "kinase", "cascade"], "h": {"id": "C0248868", "name": "C0248868#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [22, 23]}}
{"token": ["In", "one", "of", "the", "two", "patients", ",", "chronic", "calcium", "repletion", "with", "C0011947#ent", "<e1>", "calcium", "was", "associated", "with", "improvement", "in", "C1457887#ent", "<e2>", "a", "decrease", "in", "left", "ventricular", "dilatation"], "h": {"id": "C0011947", "name": "C0011947#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [19, 20]}}
{"token": ["However", ",", "using", "humanized", "antibodies", "the", "C1416488#ent", "<e1>", "efficacy", "has", "been", "demonstrated", "in", "autoimmune", "diseases", "psoriasis", ",", "C0026769#ent", "<e2>", "inflammatory", "bowel", "disease"], "h": {"id": "C1416488", "name": "C1416488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [17, 18]}}
{"token": ["In", "searching", "for", "potential", "C0694888#ent", "<e1>", "modulators", "through", "protein-protein", "interaction", "we", "identified", "the", "C1417509#ent", "<e2>", "MVP", ")", "as", "a", "dominant", "PTEN-binding", "protein", "a", "yeast", "two-hybrid", "screen"], "h": {"id": "C0694888", "name": "C0694888#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417509", "name": "C1417509#ent", "pos": [13, 14]}}
{"token": ["Blocking", "IL-1", "receptors", "C1537381#ent", "<e1>", "by", "addition", "of", "100", "ng/mL", "IL-1", "receptor", "antagonist", "C0245109#ent", "<e2>", ")", "before", "stimulation", "with", "LPS", "or", "IL-1beta", "abrogated", "the", "increase", "in", "mannose", "receptor-mediated", "uptake", "."], "h": {"id": "C1537381", "name": "C1537381#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0245109", "name": "C0245109#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "we", "provide", "evidence", "that", "C1420614#ent", "<e1>", "and", "Tbx5", "are", "involved", "in", "controlling", "C0030196#ent", "<e2>", "identity", "."], "h": {"id": "C1420614", "name": "C1420614#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [15, 16]}}
{"token": ["Using", "a", "conditional", "allele", "C1420614#ent", "<e1>", ",", "we", "have", "ablated", "C1420614#ent", "<e1>", "function", "before", "and", "after", "C0030196#ent", "<e1>", "initiation", "."], "h": {"id": "C1420614", "name": "C1420614#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [16, 17]}}
{"token": ["T3", "treatment", "resulted", "in", "serum", "glucose", "insulin", "increases", "similar", "to", "C0040864#ent", "<e1>", ",", "but", "more", "moderate", "in", "C0027726#ent", "<e2>", "vs.", "control", "rats", "and", "in", "marked", "reduction", "in", "liver", "glycogen", "content", "."], "h": {"id": "C0040864", "name": "C0040864#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [17, 18]}}
{"token": ["Because", "C2939773#ent", "<e1>", "donates", "a", "methyl", "group", "homocysteine", "to", "produce", "methionine", ",", "C0016412#ent", "<e2>", "decrease", "polyamine", "synthesis", "."], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0016412", "name": "C0016412#ent", "pos": [12, 13]}}
{"token": ["The", "pH", "optimum", "of", "the", "C0014442#ent", "<e1>", "for", "whole", "calf", "histones", "and", "N-benzoyltyrosine", ",", "C0058978#ent", "<e2>", "BTEE", ")", "was", "at", "7.0", "and", "7.0", "-", "7.5", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0058978", "name": "C0058978#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "C3811061#ent", "<e1>", "concentration", "and", "pH", "on", "binding", "to", "purified", "rat", "C0023899#ent", "<e2>", "plasma", "membranes", "compared", "for", "labelled", "insulin", "and", "two", "covalently-linked", "insulin", "dimers", "."], "h": {"id": "C3811061", "name": "C3811061#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [13, 14]}}
{"token": ["The", "infusion", "of", "EMS", ",", "as", "compared", "to", "C3811061#ent", "<e1>", ",", "failed", "to", "affect", "paraovarian", "adipose", "tissue", "liver", "weight", "C0023899#ent", "<e2>", "or", "muscle", "glycogen", "and", "insulinemia", "."], "h": {"id": "C3811061", "name": "C3811061#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [19, 20]}}
{"token": ["The", "C3811061#ent", "<e1>", "expressed", "in", "the", "C0023899#ent", "<e2>", "as", "a", "transcript", "473", "bp", "in", "size", "and", "encodes", "a", "putative", "protein", "of", "124", "amino", "acid", "residues", "."], "h": {"id": "C3811061", "name": "C3811061#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}}
{"token": ["To", "investigate", "the", "expression", "and", "regulation", "of", "CD80", ",", "CD86", ",", "and", "C2985420#ent", "<e1>", "sialoadenitis", "and", "interstitial", "nephritis", "patients", "with", "C0151449#ent", "<e2>", "SS", ")", "."], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [20, 21]}}
{"token": ["DDE", "(", "a", "metabolite", "of", "dichloro-diphenyl-trichloroethane", ")", "was", "present", "in", "22", "of", "the", "C0010709#ent", "<e1>", "samples", "and", "C1418288#ent", "<e2>", "was", "detected", "in", "19", "of", "the", "C0010709#ent", "<e1>", "samples", "."], "h": {"id": "C1418288", "name": "C1418288#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [13, 14]}}
{"token": ["When", "C0058415#ent", "<e1>", "was", "administered", "with", "C0301366#ent", "<e2>", "plus", "phentolamine", ",", "there", "was", "an", "immediate", "hypotensive", "effect", "."], "h": {"id": "C0058415", "name": "C0058415#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0301366", "name": "C0301366#ent", "pos": [6, 7]}}
{"token": ["We", "evaluated", "the", "effect", "of", "moderate", "alcohol", "consumption", "the", "C1413353#ent", "<e1>", "polymorphism", "and", "clinical", "variables", "HDL", "cholesterol", "other", "lipoprotein", "parameters", "in", "insulin-dependent", "diabetic", "C3273872#ent", "<e2>", ")", "men", "."], "h": {"id": "C1413353", "name": "C1413353#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "that", "11-KT", "is", "produced", "in", "the", "somatic", "cells", "the", "testis", "under", "the", "influence", "of", "C3536870#ent", "<e1>", ",", "and", "that", "sperm", "can", "convert", "17alpha-OHP", "to", "C1704716#ent", "<e2>", "."], "h": {"id": "C3536870", "name": "C3536870#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1704716", "name": "C1704716#ent", "pos": [27, 28]}}
{"token": ["These", "results", "indicate", "that", "C3536870#ent", "<e1>", "(", "GtH", ")", "and", "C1704716#ent", "<e2>", "are", "related", "to", "the", "final", "stage", "of", "testicular", "maturation", "and", "that", "GtH", "acts", "through", "production", "of", "C1704716#ent", "<e2>", "in", "the", "testis", "."], "h": {"id": "C3536870", "name": "C3536870#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704716", "name": "C1704716#ent", "pos": [10, 11]}}
{"token": ["MGK", "identified", "C0017339#ent", "<e1>", "are", "critical", "for", "fitness", "in", "the", "absence", "of", "C0301713#ent", "<e2>", "and", "was", "further", "applied", "to", "identify", "genes", "whose", "inactivation", "causes", "bacterial", "cell", "death", "exposure", "to", "bacteriostatic", "antibiotic", "chloramphenicol"], "h": {"id": "C0017339", "name": "C0017339#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0301713", "name": "C0301713#ent", "pos": [12, 13]}}
{"token": ["These", "apparent", "discrepancies", "between", "C0086376#ent", "<e1>", "that", "display", "C1333356#ent", "<e2>", "address", "the", "question", "of", "the", "control", "of", "the", "cks", "oligomerization", "process", "and", "its", "link", "to", "the", "biological", "function"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333356", "name": "C1333356#ent", "pos": [8, 9]}}
{"token": ["p67", ",", "a", "cellular", "glycoprotein", "protects", "eIF2alpha", "from", "phosphorylation", "by", "inhibitory", "C0031727#ent", "<e1>", "such", "as", "double-stranded", "RNA", "eIF2", "kinase", "PKR", ",", "and", "C3275244#ent", "<e2>", "thus", "promotes", "protein", "synthesis", "mammalian", "cells"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3275244", "name": "C3275244#ent", "pos": [22, 23]}}
{"token": ["After", "recovering", "from", "C1535939#ent", "<e1>", "in", "two", "months", ",", "he", "complained", "of", "C0740651#ent", "<e2>", "such", "as", "constipation", ",", "nausea", "and", "vomiting", ",", "spontaneous", "tingling", "sensations", "in", "the", "lower", "extremities", "and", "orthostatic", "dizziness", "fainting", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0740651", "name": "C0740651#ent", "pos": [12, 13]}}
{"token": ["Posthatching", ",", "the", "microvilli", "and", "all", "C1453952#ent", "<e1>", "layers", "increase", "in", "thickness", "and", "density", ",", "particularly", "the", "C0919509#ent", "<e2>", ",", "boundary", ",", "and", "coarse", "outer", "meshwork", "layers", "."], "h": {"id": "C1453952", "name": "C1453952#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [17, 18]}}
{"token": ["It", "is", "a", "feature", "of", "the", "C0236099#ent", "<e1>", "are", "often", "associated", "with", "epilepsy", ":", "hypogonadotropic", "hypogonadism", "hypergonadotropic", "hypogonadism", "and", "functional", "C0268528#ent", "<e2>", "."], "h": {"id": "C0236099", "name": "C0236099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [20, 21]}}
{"token": ["The", "clinical", "signs", "diagnosis", ",", "and", "treatment", "of", "canine", "and", "feline", "demodicosis", ",", "canine", "scabies", "notoedric", "mange", "C0277438#ent", "<e1>", ",", "otodectic", "mange", "and", "other", "mite", "C0851341#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C0277438", "name": "C0277438#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0851341", "name": "C0851341#ent", "pos": [25, 26]}}
{"token": ["The", "marked", "difference", "in", "triglyceride", "levels", "between", "the", "treatment", "groups", "us", "to", "evaluate", "the", "lipoprotein", "lipase", "C1453952#ent", "<e1>", "activities", "in", "20", "C0020473#ent", "<e2>", ",", "nondiabetic", "patients", "."], "h": {"id": "C1453952", "name": "C1453952#ent", "pos": [16, 17]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [21, 22]}}
{"token": ["These", "polymers", "chemically", "incorporate", "either", "salicylic", "acid", "SA", ")", "or", "5-(2',4'-difluorophenyl)salicylic", "acid", "(", "C0012228#ent", "<e1>", ")", "into", "the", "polymeric", "backbone", "and", "release", "the", "C0003211#ent", "<e2>", "upon", "hydrolysis", "."], "h": {"id": "C0012228", "name": "C0012228#ent", "pos": [13, 14]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [23, 24]}}
{"token": ["These", "experiments", "provide", "strong", "support", "for", "the", "concept", "that", "transformation", "by", "activated", "C0034678#ent", "<e1>", "is", "accompanied", "by", "an", "induction", "of", "C0029282#ent", "<e2>", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [20, 21]}}
{"token": ["Total", "cellular", "activities", "carnitine", ":", "C4284028#ent", "<e1>", "crotonase", ",", "3-hydroxyacyl-CoA", "dehydrogenase", "3-keto-acyl-CoA", "thiolase", ",", "C0008855#ent", "<e2>", "NADH", ":", "cytochrome", "c", "oxidoreductase", "succinate", ":", "cytochrome", "c", "oxidoreductase", "and", "cytochrome", "c", "oxidase", "measured", "in", "contralateral", "and", "stimulated", "muscles", "at", "various", "times", "."], "h": {"id": "C4284028", "name": "C4284028#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008855", "name": "C0008855#ent", "pos": [14, 15]}}
{"token": ["Additionally", ",", "the", "expression", "of", "C1705819#ent", "<e1>", "mRNA", "is", "C0038317#ent", "<e2>", "related", "and", "may", "be", "hormonally", "regulated", "."], "h": {"id": "C1705819", "name": "C1705819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [9, 10]}}
{"token": ["The", "use", "of", "capillary", "electrophoresis", "the", "determination", "of", "catechol-O-methyltransferase", "(", "C0007407#ent", "<e1>", ")", "activity", "with", "C0036079#ent", "<e2>", "a", "substrate", "was", "investigated", "."], "h": {"id": "C0007407", "name": "C0007407#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036079", "name": "C0036079#ent", "pos": [15, 16]}}
{"token": ["It", "is", "also", "suggested", "that", "C0013617#ent", "<e1>", "antagonizes", "tubocurarine", "by", "acting", "as", "a", "partial", "C2987634#ent", "<e2>", "at", "the", "motor", "nerve", "terminal"], "h": {"id": "C0013617", "name": "C0013617#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "C1420398#ent", "<e1>", "nSREBP1", ")", ",", "recently", "associated", "with", "cell", "growth", "regulation", "was", "downregulated", "after", "C1415467#ent", "<e2>", "treatment", "in", "both", "cell", "lines"], "h": {"id": "C1420398", "name": "C1420398#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415467", "name": "C1415467#ent", "pos": [16, 17]}}
{"token": ["We", "compared", "the", "thermodynamic", "characteristics", ",", "and", "studied", "effects", "of", "pH", "on", "the", "stability", ",", "of", "individual", "domains", "rod", ",", "C0027111#ent", "<e1>", "LMM", ")", ",", "and", "C0027117#ent", "<e2>", "S-2", ")", "."], "h": {"id": "C0027111", "name": "C0027111#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0027117", "name": "C0027117#ent", "pos": [26, 27]}}
{"token": ["Inhibition", "of", "the", "undesired", "activity", "of", "C1721278#ent", "<e1>", "will", "help", "reduce", "risks", "of", "premature", "birth", "C0027765#ent", "<e2>", "the", "development", "of", "cancer", "."], "h": {"id": "C1721278", "name": "C1721278#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [15, 16]}}
{"token": ["Fifteen", "patients", "aged", "11", "-", "17", "with", "a", "history", "of", "C0149931#ent", "<e1>", "with", "or", "without", "aura", "were", "treated", "with", "C0937898#ent", "<e2>", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0937898", "name": "C0937898#ent", "pos": [19, 20]}}
{"token": ["C1705431#ent", "<e1>", "co-stimulation", "is", "essential", "for", "activating", "resting", "T", "cells", "antigen", "recognition", "the", "C0524889#ent", "<e2>"], "h": {"id": "C1705431", "name": "C1705431#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524889", "name": "C0524889#ent", "pos": [13, 14]}}
{"token": ["C1705431#ent", "<e1>", "co-stimulation", "is", "necessary", "to", "activate", "resting", "T", "cells", "antigen", "recognition", "the", "C0524889#ent", "<e2>"], "h": {"id": "C1705431", "name": "C1705431#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524889", "name": "C0524889#ent", "pos": [13, 14]}}
{"token": ["With", "PCR", ",", "the", "ability", "to", "diagnose", "CNS", "C0042769#ent", "<e1>", "improved", ",", "particularly", "for", "C0019348#ent", "<e2>", "enteroviral", "infections"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [14, 15]}}
{"token": ["Treatment", "of", "the", "rat", "central", "nervous", "system", "cell", "line", "with", "aggregates", "of", "C1705543#ent", "<e1>", "was", "found", "to", "induce", "the", "tyrosine", "phosphorylation", "C1419150#ent", "<e2>", "within", "30", "min", ",", "nearly", "24", "hr", "prior", "to", "significant", "cell", "death"], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419150", "name": "C1419150#ent", "pos": [21, 22]}}
{"token": ["The", "cell", "line", "showed", "greatest", "reduction", "(", "85", "-", "90", "%", ")", "of", "p53", "expression", "showed", "decreased", "C0079471#ent", "<e1>", "promoter", "activation", "after", "DNA", "damage", "C0006812#ent", "<e2>", ",", "etoposide", "and", "MMS", "."], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006812", "name": "C0006812#ent", "pos": [24, 25]}}
{"token": ["Previously", ",", "it", "was", "suggested", "that", "an", "C0672045#ent", "<e1>", "AK", ")", "2", "related", "C0017337#ent", "<e2>", "on", "chromosome", "2", "confirmed", "by", "Southern", "analysis", "somatic", "cell", "hybrid", "cell", "lines", "may", "be", "a", "processed", "pseudogene", "."], "h": {"id": "C0672045", "name": "C0672045#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["Single", "base", "substitutions", "have", "been", "identified", "in", "aldolase", ",", "triosephosphate", "isomerase", "G6PD", "and", "C0672045#ent", "<e1>", "variants", "by", "the", "cloning", "and", "nucleotide", "sequence", "the", "patients", "'", "C0017337#ent", "<e2>", "."], "h": {"id": "C0672045", "name": "C0672045#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [25, 26]}}
{"token": ["Human-derived", "MCF-7", "breast", "cancer", "cells", "lack", "C0907533#ent", "<e1>", "expression", "of", "PKC-alpha", "or", "C0752501#ent", "<e2>", "at", "detectable", "levels", "were", "transfected", "with", "full-length", "PKC-alpha", "or", "PKC-theta", "genes", "driven", "by", "the", "ecdysone", "promoter", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752501", "name": "C0752501#ent", "pos": [12, 13]}}
{"token": ["We", "find", "that", "expression", "of", "a", "C0907533#ent", "<e1>", "active", "mutant", "of", "C0752501#ent", "<e2>", "potently", "induces", "NF-kappaB", "activation", "stimulates", "the", "RE/AP", "composite", "enhancer", "from", "the", "interleukin-2", "gene"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752501", "name": "C0752501#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "27-year-old", "woman", "who", "presented", "with", "partial", "seizure", "stroke-like", "episodes", "C0018989#ent", "<e1>", ",", "hemianopia", "and", "hemihypethesia", ",", "C4021534#ent", "<e2>", "migraine-like", "headache", "and", "lactic", "acidosis"], "h": {"id": "C0018989", "name": "C0018989#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4021534", "name": "C4021534#ent", "pos": [19, 20]}}
{"token": ["The", "mode", "of", "inheritance", "in", "C1832648#ent", "<e1>", "of", "two", "families", "was", "thought", "to", "be", "C2936739#ent", "<e2>", "and", "the", "C1832648#ent", "<e1>", "of", "the", "other", "was", "probably", "inherited", "in", "an", "autosomal", "recessive", "."], "h": {"id": "C1832648", "name": "C1832648#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [14, 15]}}
{"token": ["Sequence", "analysis", "L/B/K", "C1424288#ent", "<e1>", "cDNA", "isolated", "from", "one", "of", "the", "patient-derived", "fibroblast", "lines", "a", "point", "mutation", "that", "converted", "C2917660#ent", "<e2>", "of", "mature", "L/B/K", "C1424288#ent", "<e1>", "from", "alanine", "to", "threonine", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1424288", "name": "C1424288#ent", "pos": [3, 4]}}
{"token": ["Homology", "at", "the", "C2917660#ent", "<e1>", "level", "of", "the", "mouse", "placental", "C1424288#ent", "<e2>", "is", "90", "%", "to", "the", "human", "liver", "isozyme", "only", "55", "%", "to", "the", "human", "placental", "counterpart", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1424288", "name": "C1424288#ent", "pos": [10, 11]}}
{"token": ["The", "requirement", "of", "the", "C1424250#ent", "<e1>", "inflammasome", "was", "specific", "for", "IL-1beta", "in", "that", "secretion", "of", "C1710304#ent", "<e2>", "was", "independent", "of", "C1424250#ent", "<e1>", "or", "Asc", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [4, 5]}}
{"token": ["Tubule", "hypoxia", "in", "mice", "with", "progressive", "C0022658#ent", "<e1>", "Os/+", ")", "was", "assessed", "by", "injecting", "C1521807#ent", "<e2>", ",", "a", "nitroimidazole", "compound", "that", "preferentially", "binds", "to", "cells", "undergoing", "anaerobic", "metabolism", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1521807", "name": "C1521807#ent", "pos": [14, 15]}}
{"token": ["Compound", "17c", "was", "found", "to", "be", "highly", "selective", "for", "Src", "kinase", "tested", "against", "a", "panel", "of", "other", "C0031727#ent", "<e1>", ",", "with", "modest", "selectivity", "versus", "the", "Src", "family", "kinases", "Lyn", "and", "C1442788#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [17, 18]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [30, 31]}}
{"token": ["At", "the", "molecular", "level", "RPTPepsilon", "dephosphorylates", "and", "activates", "Src", "and", "the", "related", "C0031727#ent", "<e1>", "Yes", "and", "C1442788#ent", "<e2>", ",", "and", "the", "activities", "of", "these", "C0031727#ent", "<e1>", "are", "significantly", "reduced", "in", "tumor", "cells", "RPTPepsilon", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [16, 17]}}
{"token": ["Cotransfection", "of", "tau", "and", "C0031727#ent", "<e1>", "showed", "that", "Tyr-18", "was", "the", "major", "site", "for", "C1442788#ent", "<e2>", "phosphorylation", ",", "but", "Tyr-394", "was", "the", "main", "residue", "for", "Abl", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [14, 15]}}
{"token": ["Also", ",", "by", "transiently", "expressing", "mutant", "forms", "of", "this", "C0031727#ent", "<e1>", ",", "we", "demonstrated", "that", "C1442788#ent", "<e2>", "is", "required", "for", "the", "integrin", "associated", "PI", "3", "K", "activity", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [15, 16]}}
{"token": ["The", "glial", "glutamate", "transporter", "C2985245#ent", "<e1>", "is", "primarily", "responsible", "for", "clearance", "of", "glutamate", "from", "the", "synaptic", "cleft", "loss", "of", "C2985245#ent", "<e1>", "has", "been", "previously", "reported", "in", "C0002736#ent", "<e1>", "ALS", ")", "and", "Alzheimer's", "disease"], "h": {"id": "C2985245", "name": "C2985245#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [26, 27]}}
{"token": ["This", "results", "in", "classification", "of", "childhood", "C0027947#ent", "<e1>", "to", "the", "clinical", "picture", "a", "serious", "form", "(", "C1853118#ent", "<e2>", ")", "and", "cyclic", "neutropenia", "be", "differentiated", "from", "the", "benign", "form", "described", "here", "."], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C1853118", "name": "C1853118#ent", "pos": [16, 17]}}
{"token": ["In", "summary", ",", "C0064113#ent", "<e1>", "showed", "activity", "in", "human", "studies", "of", "C0004030#ent", "<e2>", ",", "cryptococcosis", "and", "histoplasmosis", "with", "minimal", "toxicity", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [11, 12]}}
{"token": ["Forskolin", "and", "sodium", "nitroprusside", "inhibited", "both", "platelet", "aggregation", "C2744579#ent", "<e1>", "release", ",", "but", "not", "the", "shape", "change", "induced", "by", "C0050969#ent", "<e2>", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0050969", "name": "C0050969#ent", "pos": [19, 20]}}
{"token": ["Exposure", "of", "HTC", "cells", "to", "6", "mM", "C0142812#ent", "<e1>", "20", "h", "results", "in", "significantly", "reduced", "amounts", "of", "C0671924#ent", "<e2>"], "h": {"id": "C0142812", "name": "C0142812#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0671924", "name": "C0671924#ent", "pos": [17, 18]}}
{"token": ["The", "left", "ventricular", "afterload", "was", "decreased", "by", "C0040779#ent", "<e1>", ",", "and", "a", "low", "dose", "positive", "C0242913#ent", "<e2>", "dobutamine", ",", "was", "added", "."], "h": {"id": "C0040779", "name": "C0040779#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242913", "name": "C0242913#ent", "pos": [15, 16]}}
{"token": ["Additionally", ",", "C1420882#ent", "<e1>", "caused", "secretion", "of", "C1366571#ent", "<e2>", "from", "the", "human", "eosinophilic", "cell", "line", "AML14", "-", "3D10", ",", "which", "does", "not", "possess", "the", "alpha", "chain", "of", "FcepsilonRI", "."], "h": {"id": "C1420882", "name": "C1420882#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [7, 8]}}
{"token": ["C0410174#ent", "<e1>", "FCMD", ")", "is", "an", "autosomal", "recessive", "severe", "C0026850#ent", "<e2>", "associated", "with", "brain", "anomalies"], "h": {"id": "C0410174", "name": "C0410174#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0026850", "name": "C0026850#ent", "pos": [9, 10]}}
{"token": ["The", "prohormone", "convertase", "C1418600#ent", "<e1>", "is", "one", "of", "the", "major", "C1174937#ent", "<e2>", "enzymes", "responsible", "for", "the", "formation", "of", "small", "bioactive", "peptides", "in", "neural", "and", "endocrine", "cells"], "h": {"id": "C1418600", "name": "C1418600#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1174937", "name": "C1174937#ent", "pos": [10, 11]}}
{"token": ["The", "other", "calcium-binding", "proteins", "C3889446#ent", "<e1>", "in", "25", "-", "45", "%", "of", "the", "C3537453#ent", "<e2>", "samples", "that", "we", "studied", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537453", "name": "C3537453#ent", "pos": [13, 14]}}
{"token": ["Olanzapine", "was", "administered", ",", "after", "which", "the", "child", "had", "hyperthermia", ",", "C0393593#ent", "<e1>", "and", "more", "pronounced", "restlessness", ",", "once", "again", "consistent", "with", "C1744687#ent", "<e2>", "."], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1744687", "name": "C1744687#ent", "pos": [22, 23]}}
{"token": ["We", "experienced", "a", "C0013264#ent", "<e1>", "DMD", ")", "patient", "with", "severe", "congestive", "heart", "failure", "C0018802#ent", "<e2>", ")", "successfully", "treated", "with", "milrinone", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "C0013264#ent", "<e1>", "DMD", ")", "and", "severe", "C0018802#ent", "<e2>", "CHF", ")", "frequently", "feel", "mental", "anguish", "to", "severe", "mental", "and", "physical", "restriction"], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}}
{"token": ["The", "C3536868#ent", "<e1>", "TDH3", ")", "is", "a", "glycolytic", "C1333402#ent", "<e2>", "is", "abundantly", "transcribed", "in", "Saccharomyces", "cerevisiae"], "h": {"id": "C3536868", "name": "C3536868#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [8, 9]}}
{"token": ["Facial", "nerve", "paralysis", "symptoms", "of", "audiovestibular", "nerve", "dysfunction", "be", "the", "first", "indication", "of", "one", "of", "the", "group", "of", "C0005940#ent", "<e1>", "as", "the", "C0029456#ent", "<e2>", "."], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0029456", "name": "C0029456#ent", "pos": [22, 23]}}
{"token": ["C0012262#ent", "<e1>", ",", "monoglycerides", ",", "and", "C0041420#ent", "<e2>", "40", "and", "85", "in", "Triton", "X-100", "hydrolyzed", "at", "rates", "comparable", "to", "those", "of", "phospholipids", "and", "lysophospholipids", "."], "h": {"id": "C0012262", "name": "C0012262#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041420", "name": "C0041420#ent", "pos": [6, 7]}}
{"token": ["Impaired", "pressor", "function", "C1623038#ent", "<e1>", "may", "be", "specific", "to", "certain", "C2987634#ent", "<e2>", "and", "vascular", "territories", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}}
{"token": ["However", ",", "immunogold", "studies", "showed", "a", "peripheral", "labeling", "of", "the", "X-prolyl-dipeptidyl", "aminopeptidase", "the", "C0963228#ent", "<e1>", ",", "and", "the", "C0207564#ent", "<e2>", "."], "h": {"id": "C0963228", "name": "C0963228#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0207564", "name": "C0207564#ent", "pos": [18, 19]}}
{"token": ["Both", "strains", "had", "C0031727#ent", "<e1>", "PTSs", ")", "for", "glucose", "and", "C1260222#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1260222", "name": "C1260222#ent", "pos": [10, 11]}}
{"token": ["There", "are", "only", "two", "drugs", "available", "for", "the", "treatment", "and", "control", "of", "C0036323#ent", "<e1>", "and", "food-borne", "trematodiasis", ",", "C0032911#ent", "<e2>", "and", "triclabendazole", "."], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [18, 19]}}
{"token": ["The", "remaining", "60", "%", "of", "the", "C1332428#ent", "<e1>", "epitopes", "were", "fully", "occluded", "in", "the", "native", "C0027203#ent", "<e2>", "and", "never", "showed", "surface", "exposure", "."], "h": {"id": "C1332428", "name": "C1332428#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "we", "cloned", "a", "rat", "C0769218#ent", "<e1>", "investigated", "the", "intestinal", "distribution", "and", "proteolytic", "properties", "of", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C0769218", "name": "C0769218#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [20, 21]}}
{"token": ["The", "frozen", "muscle", "biopsied", "specimens", "from", "91", "neuromuscular", "disorders", "muscular", "dystrophies", "C0751356#ent", "<e1>", "neurogenic", "muscular", "disorders", "were", "stained", "by", "using", "monoclonal", "antibody", "the", "C4084825#ent", "<e2>", ",", "and", "the", "positive", "cells", "a", "whole", "sectional", "field", "were", "counted", "."], "h": {"id": "C0751356", "name": "C0751356#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4084825", "name": "C4084825#ent", "pos": [23, 24]}}
{"token": ["The", "CGRP1-receptor", "antagonist", ",", "h", "alpha", "CGRP8", "-", "37", "reversibly", "antagonized", "the", "C0042402#ent", "<e1>", "induced", "by", "h", "alpha", "C1704715#ent", "<e2>", "with", "an", "apparent", "pK1", "of", "8.03", "+", "/-", "0.21", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704715", "name": "C1704715#ent", "pos": [18, 19]}}
{"token": ["It", "appears", "that", "the", "nicotine-induced", "relaxation", "is", "associated", "with", "stimulation", "of", "C0042402#ent", "<e1>", "NO", "and", "C1704715#ent", "<e2>", ",", "and", "adrenergic", "neurogenic", "vasoconstriction", "predominates", "over", "the", "neurogenic", "vasodilatation", "dog", "saphenous", "arteries", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704715", "name": "C1704715#ent", "pos": [15, 16]}}
{"token": ["The", "potent", "antiarrhythmic", "drug", "C0002598#ent", "<e1>", "(", "AMIO", ")", "exhibits", "C1527358#ent", "<e2>", ",", "which", "is", "thought", "to", "be", "related", "to", "its", "interaction", "with", "biological", "membranes"], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1527358", "name": "C1527358#ent", "pos": [10, 11]}}
{"token": ["Bone", "marrow", "aspiration", "massive", "proliferation", "of", "blasts", "that", "were", "positive", "for", "CD13", ",", "CD33", ",", "CD34", ",", "CD56", "and", "C0027021#ent", "<e1>", ",", "and", "negative", "for", "other", "T-cell", ",", "B-cell", "and", "C0021345#ent", "<e2>", "markers", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [30, 31]}}
{"token": ["We", "report", "a", "simplified", "Boyden", "chamber", "method", "which", "utilizes", "C0027021#ent", "<e1>", "(", "MPO", ")", "specific", "to", "neutrophilic", "and", "C0021345#ent", "<e2>", "leukocytes", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [18, 19]}}
{"token": ["Patients", "included", "in", "the", "study", "were", "over", "40", "years", "of", "age", "and", "had", "symptoms", "suggestive", "of", "pancreatic", "disease", "as", "upper", "abdominal", "pain", "C2364135#ent", "<e1>", "or", "mass", ",", "jaundice", ",", "weight", "loss", "or", "C0011849#ent", "<e2>", "."], "h": {"id": "C2364135", "name": "C2364135#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [32, 33]}}
{"token": ["The", "results", "showed", "that", "unilateral", "injections", "of", "C0079286#ent", "<e1>", "into", "the", "C2828027#ent", "<e2>", "produced", "a", "depression", "of", "locomotor", "activity", "followed", "by", "a", "stimulation", "."], "h": {"id": "C0079286", "name": "C0079286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2828027", "name": "C2828027#ent", "pos": [11, 12]}}
{"token": ["The", "capacity", "of", "CPC", "plus", "BK", "to", "increase", "NO", "signal", "was", "blunted", "by", "the", "NO", "synthase", "inhibitor", "C0068821#ent", "<e1>", "and", "was", "enhanced", "in", "the", "presence", "either", "of", "superoxide", "dismutase", "C0007367#ent", "<e2>", "."], "h": {"id": "C0068821", "name": "C0068821#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [29, 30]}}
{"token": ["Despite", "the", "superficial", "resemblance", "to", "C0178703#ent", "<e1>", "it", "is", "believed", "that", "this", "case", "represents", "Crohn's", "disease", "C0521173#ent", "<e2>", "skin", "and", "periosteum", "."], "h": {"id": "C0178703", "name": "C0178703#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0521173", "name": "C0521173#ent", "pos": [16, 17]}}
{"token": ["Staurosporine", ",", "an", "C0002062#ent", "<e1>", "isolated", "from", "Streptomyces", "species", "is", "commonly", "used", "as", "a", "C0033634#ent", "<e2>", "PKC", ")", "inhibitor", "in", "animal", "investigations"], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [14, 15]}}
{"token": ["In", "competition", "experiments", "staurosporine", "inhibited", "[3H]DMS", "binding", "with", "a", "Ki", "of", "4.7", "+", "/-", "0.6", "nM", ",", "indicating", "that", "the", "two", "C0002062#ent", "<e1>", "had", "a", "similar", "potency", "for", "C0033634#ent", "<e2>", "."], "h": {"id": "C0002062", "name": "C0002062#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [28, 29]}}
{"token": ["ABT-492", "was", "a", "potent", "inhibitor", "of", "C1336767#ent", "<e1>", "and", "unlike", "the", "comparators", ",", "DNA", "gyrase", "C0082329#ent", "<e2>", "either", "Staphylococcus", "aureus", "Escherichia", "coli", "almost", "equally", "sensitive", "to", "ABT-492", "."], "h": {"id": "C1336767", "name": "C1336767#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0082329", "name": "C0082329#ent", "pos": [15, 16]}}
{"token": ["C1424930#ent", "<e1>", "APOBEC3G", "referred", "to", "here", "as", "C1143167#ent", "<e2>", "is", "a", "potent", "antiretroviral", "host", "factor", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "."], "h": {"id": "C1424930", "name": "C1424930#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1143167", "name": "C1143167#ent", "pos": [7, 8]}}
{"token": ["Combined", "C1414571#ent", "<e1>", "+", "GDX", "inhibited", "only", "C1334081#ent", "<e2>", ",", "and", "testosterone", "and", "dihydrotestosterone", "(", "DHT", ")", "restored", "C1334081#ent", "<e2>", "mRNA", "."], "h": {"id": "C1414571", "name": "C1414571#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334081", "name": "C1334081#ent", "pos": [7, 8]}}
{"token": ["Recurrent", "C0040921#ent", "<e1>", "uncommon", ",", "and", "significant", "C0025872#ent", "<e2>", "resistance", "remains", "rare", "."], "h": {"id": "C0040921", "name": "C0040921#ent", "pos": [1, 2]}, "relation": "may_be_prevented_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [7, 8]}}
{"token": ["C0016424#ent", "<e1>", "also", "inhibited", "cyclic", "C4285220#ent", "<e2>", "accumulation", "induced", "by", "non", "hormonal", "agents", "such", "as", "forskolin", "and", "cholera", "toxin", "bypass", "the", "receptor", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4285220", "name": "C4285220#ent", "pos": [5, 6]}}
{"token": ["It", "is", "known", "that", "involuntary", "movements", "patients", "with", "C0270742#ent", "<e1>", "cause", "cervical", "spondylosis", "especially", "at", "C3/4", "and", "C1710517#ent", "<e2>", "level", ")", "."], "h": {"id": "C0270742", "name": "C0270742#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1710517", "name": "C1710517#ent", "pos": [17, 18]}}
{"token": ["Palpebral", "ptosis", "lasting", "1", "-", "3", "weeks", ")", "was", "the", "most", "frequent", "side", "effect", "16/107", "C0235267#ent", "<e1>", "treated", ")", "but", "was", "not", "related", "to", "dose", "of", "C0700702#ent", "<e2>", "or", "number", "of", "inoculation", "sites", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0700702", "name": "C0700702#ent", "pos": [26, 27]}}
{"token": ["C1423891#ent", "<e1>", "is", "a", "rate-limiting", "C0027203#ent", "<e2>", "in", "the", "synthesis", "of", "glutathione", ",", "a", "major", "contributor", "to", "anti-oxidant", "protection", "in", "the", "lung", "."], "h": {"id": "C1423891", "name": "C1423891#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}}
{"token": ["20", "patients", "with", "an", "attack", "of", "C0018099#ent", "<e1>", "in", "this", "double-blind", "study", "ten", "patients", "received", "N-(2,6-dichloro-m-tolyl)anthranilic", "acid", "sodium", "salt", "C0025041#ent", "<e2>", "Meclomen", ")", "and", "ten", "indometacin", "."], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0025041", "name": "C0025041#ent", "pos": [19, 20]}}
{"token": ["TGF-beta1-induced", "apoptosis", "and", "C1420138#ent", "<e1>", "were", "associated", "with", "activation", "of", "C0010531#ent", "<e2>", "PKA", ")", "and", "signal", "transducers", "activators", "of", "transcription", "3", "STAT3", ")", "."], "h": {"id": "C1420138", "name": "C1420138#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [10, 11]}}
{"token": ["This", "pattern", "of", "changes", "was", "inconsistent", "with", "a", "C0020676#ent", "<e1>", ",", "but", "has", "recently", "been", "found", "in", "many", "C0040128#ent", "<e2>"], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [18, 19]}}
{"token": ["C0037982#ent", "<e1>", "had", "efficacy", "similar", "to", "that", "of", "C0208216#ent", "<e2>", "50", "to", "300", "mg/day", "in", "a", "comparative", "phase", "III", "trial", "159", "patients", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0208216", "name": "C0208216#ent", "pos": [8, 9]}}
{"token": ["Extrapyramidal", "symptoms", "EPS", ")", "tended", "to", "occur", "less", "often", "and", "were", "generally", "milder", "with", "C0037982#ent", "<e1>", "than", "with", "haloperidol", "or", "C0208216#ent", "<e2>", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0208216", "name": "C0208216#ent", "pos": [20, 21]}}
{"token": ["Erythropoiesis", "requires", "erythropoietin", "(", "Epo", ")", "and", "stem", "cell", "factor", "C1366480#ent", "<e1>", ")", "signaling", "via", "their", "receptors", "C1333342#ent", "<e2>", "and", "c-Kit", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333342", "name": "C1333342#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "C1706574#ent", "<e1>", "induced", "expression", "of", "the", "C0599295#ent", "<e2>", "c-jun", ",", "in", "an", "HBE", "cell", "culture", "an", "NSCLC", "cell", "line"], "h": {"id": "C1706574", "name": "C1706574#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [8, 9]}}
{"token": ["Isolates", "from", "C0010674#ent", "<e1>", "patients", "were", "more", "resistant", "to", "all", "C0035064#ent", "<e2>", "tested", "than", "isolates", "from", "non-cystic", "fibrosis", "patients", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [10, 11]}}
{"token": ["Standard", "pharmacologic", "management", "C0010674#ent", "<e1>", "discussed", "and", "the", "role", "of", "new", "C0035064#ent", "<e2>", "in", "the", "treatment", "of", "this", "disease", "is", "explored", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["Thus", "far", ",", "three", "C0017337#ent", "<e1>", "have", "been", "identified", "that", "encode", "NEP", "-RpoTp", ",", "C0217981#ent", "<e2>", "and", "RpoTm", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0217981", "name": "C0217981#ent", "pos": [14, 15]}}
{"token": ["A", "yeast", "two-hybrid", "screen", "a", "neuronal", "library", "the", "carboxyl", "tail", "of", "C1420120#ent", "<e1>", "yielded", "clones", "expressing", "C1704929#ent", "<e2>", "."], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704929", "name": "C1704929#ent", "pos": [16, 17]}}
{"token": ["The", "presence", "of", "these", "macromolecules", "in", "the", "C0020641#ent", "<e1>", "high", "permeability", "of", "vessels", "in", "the", "C0206368#ent", "<e2>"], "h": {"id": "C0020641", "name": "C0020641#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0206368", "name": "C0206368#ent", "pos": [15, 16]}}
{"token": ["Inhibition", "of", "the", "C1420232#ent", "<e1>", "exchanger", "suppressed", "C1333574#ent", "<e2>", "stimulated", "cell", "migration", "accelerated", "the", "intracellular", "acidification", "and", "inhibited", "the", "fMLP-induced", "cell", "swelling", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [7, 8]}}
{"token": ["C3540778#ent", "<e1>", ",", "cyclosporine", "and", "pre-existing", "C0035086#ent", "<e2>", "been", "implicated", "in", "the", "pathogenesis", "of", "the", "skeletal", "lesions"], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [6, 7]}}
{"token": ["The", "C0299856#ent", "<e1>", "PAK", ")", "is", "a", "downstream", "target", "of", "C1705328#ent", "<e2>", "and", "CDC42", ",", "members", "of", "the", "Ras-related", "Rho", "subfamily", ",", "that", "mediates", "signaling", "pathway", "to", "cytoskeletal", "reorganization"], "h": {"id": "C0299856", "name": "C0299856#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [10, 11]}}
{"token": ["Ext61L-triggered", "neurite", "outgrowth", "was", "prevented", "easily", "by", "co-expressing", "inhibitory", "Rho", ",", "Cdc42", ",", "or", "C0299856#ent", "<e1>", "required", "increased", "amounts", "of", "inhibitory", "C1705328#ent", "<e2>", "."], "h": {"id": "C0299856", "name": "C0299856#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [21, 22]}}
{"token": ["Our", "results", "indicate", "that", "the", "C1421175#ent", "<e1>", "more", "than", "1,000", "kb", "proximal", "to", "the", "C0694878#ent", "<e2>", "that", "both", "genes", "are", "affected", "in", "TRPS", "II"], "h": {"id": "C1421175", "name": "C1421175#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0694878", "name": "C0694878#ent", "pos": [14, 15]}}
{"token": ["A", "trend", "was", "observed", "towards", "decreased", "frequencies", "of", "C1416650#ent", "<e1>", "deleted", "variant", "occurrence", "in", "populations", "having", "C1416650#ent", "<e1>", "as", "the", "only", "activating", "C3171597#ent", "<e1>"], "h": {"id": "C1416650", "name": "C1416650#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3171597", "name": "C3171597#ent", "pos": [22, 23]}}
{"token": ["PFGE", "analysis", "determined", "that", "C0036117#ent", "<e1>", "isolates", "from", "passerines", "in", "Georgia", "and", "Wyoming", "were", "C1516876#ent", "<e2>", "related", "."], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [14, 15]}}
{"token": ["Several", "studies", "have", "shown", "that", "5", "-", "15", "per", "cent", "of", "C0032763#ent", "<e1>", "patients", "develop", "C3887650#ent", "<e2>", ",", "while", "10", "-", "50", "%", "show", "reduced", "bone", "mineral", "density", "with", "increased", "risk", "of", "fractures", "."], "h": {"id": "C0032763", "name": "C0032763#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887650", "name": "C3887650#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "the", "binding", "characteristics", "of", "the", "C1416919#ent", "<e1>", "with", "respect", "to", "apoE", "and", "lipoprotein", "lipase", "C1334332#ent", "<e2>", ")", "were", "investigated", "."], "h": {"id": "C1416919", "name": "C1416919#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "review", "what", "is", "known", "about", "the", "intersection", "of", "glycoprotein", "folding", "oxidative", "reactions", "and", "C0017355#ent", "<e1>", "loading", ",", "emphasizing", "events", "that", "occur", "in", "the", "C1414461#ent", "<e2>", "and", "within", "the", "C0017355#ent", "<e1>", "loading", "complex"], "h": {"id": "C0017355", "name": "C0017355#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [25, 26]}}
{"token": ["EMMPRIN", ",", "which", "is", "expressed", "by", "human", "cancer", "cells", "macrophages", ",", "present", "in", "human", ",", "mouse", "and", "rabbit", "C0004153#ent", "<e1>", "and", "noted", "to", "induce", "C3494976#ent", "<e2>", "may", "be", "involved", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [24, 25]}}
{"token": ["C0004153#ent", "<e1>", "is", "a", "major", "cause", "of", "coronary", "heart", "disease", "and", "matrix", "metalloproteinases", "C3494976#ent", "<e2>", ")", "play", "an", "important", "role", "in", "atherosclerosis", "by", "degrading", "the", "extracellular", "matrix", "which", "results", "in", "cardiovascular", "remodeling"], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [13, 14]}}
{"token": ["C1337109#ent", "<e1>", "is", "implicated", "in", "common", "musculoskeletal", "disorders", "including", "C0949690#ent", "<e2>", "and", "lumbar", "disc", "disease"], "h": {"id": "C1337109", "name": "C1337109#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [9, 10]}}
{"token": ["C3541333#ent", "<e1>", "is", "the", "first", "mammalian", "C3814066#ent", "<e2>", "is", "activated", "by", "cellular", "stress", "and", "the", "activation", "is", "relatively", "specific", "for", "oxidant", "stress"], "h": {"id": "C3541333", "name": "C3541333#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3814066", "name": "C3814066#ent", "pos": [6, 7]}}
{"token": ["This", "study", "aimed", "to", "assess", "the", "contribution", "of", "C3537453#ent", "<e1>", "attenuation", "to", "C1335238#ent", "<e2>", "agonism", "action", "on", "gene", "expression", "visceral", "adipose", "tissue", "global", "metabolic", "profile"], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [12, 13]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "evaluate", "whether", "C0270697#ent", "<e1>", "in", "a", "population", "with", "pituitary", "micro-adenomas", "related", "to", "C0268528#ent", "<e2>", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [19, 20]}}
{"token": ["Sixteen", "female", "patients", "(", "mean", "age", "years", ")", "had", "pars", "intermedia", "cysts", "88", "%", "had", "menstrual", "irregularities", "63", "%", "had", "galactorrhea", ",", "31", "%", "had", "C0270697#ent", "<e1>", ",", "and", "56", "%", "had", "C0268528#ent", "<e2>", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0268528", "name": "C0268528#ent", "pos": [32, 33]}}
{"token": ["Phylogenetic", "tree", "Tokunoshima", "T.", "flavoviridis", "venom", "PLA2", "isozymes", "indicated", "that", "C1415561#ent", "<e1>", "and", "PL-X", "'", "diverged", "from", "C1706169#ent", "<e2>", "after", "branching", "of", "[Asp49]PLA2", "forms", "and", "[Lys49]PLA2", "forms", "."], "h": {"id": "C1415561", "name": "C1415561#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706169", "name": "C1706169#ent", "pos": [17, 18]}}
{"token": ["Donepezil", "(", "C0527315#ent", "<e1>", ")", "is", "a", "reversible", "C3536756#ent", "<e2>", "is", "indicated", "for", "the", "treatment", "of", "mild", "to", "moderate", "dementia", "of", "the", "Alzheimer's", "type"], "h": {"id": "C0527315", "name": "C0527315#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3536756", "name": "C3536756#ent", "pos": [8, 9]}}
{"token": ["The", "synaptically", "evoked", "excitation", "elicited", "by", "C0026269#ent", "<e1>", "was", "blocked", "by", "C1161352#ent", "<e2>", "but", "unaltered", "by", "GDEE", "whereas", "the", "PP", "excitatory", "response", "was", "blocked", "by", "GDEE", "and", "unaltered", "by", "C1161352#ent", "<e2>", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [11, 12]}}
{"token": ["In", "the", "other", "groups", "of", "patients", "with", "C1858160#ent", "<e1>", ",", "a", "mean", "of", "2.3", "helmets", "for", "a", "C0720099#ent", "<e2>", "of", "13.5", "weeks", "was", "used", "."], "h": {"id": "C1858160", "name": "C1858160#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [17, 18]}}
{"token": ["Acute", "psychological", "disorders", "C0043603#ent", "<e1>", ")", "are", "more", "common", "in", "C0014544#ent", "<e2>", "than", "in", "the", "general", "population", "with", "estimates", "varying", "from", "2", "to", "16", "%", "depending", "on", "the", "population", "of", "patients", "sampled", "."], "h": {"id": "C0043603", "name": "C0043603#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [10, 11]}}
{"token": ["The", "precursor", "of", "C1367597#ent", "<e1>", "is", "processed", "to", "form", "the", "mature", "C1367597#ent", "<e1>", "of", "51", "C3539947#ent", "<e1>", "a", "putative", "two-step", "processing", "."], "h": {"id": "C1367597", "name": "C1367597#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [15, 16]}}
{"token": ["The", "shifts", "in", "onset", "points", "ice", "crystallization", "C1367597#ent", "<e1>", "PVP", ",", "and", "C3539947#ent", "<e2>", "measured", "using", "differential", "scanning", "calorimetry"], "h": {"id": "C1367597", "name": "C1367597#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}}
{"token": ["Nedd4", "is", "a", "member", "of", "a", "growing", "family", "of", "ubiquitin-protein", "ligases", "consist", "of", "a", "C1414515#ent", "<e1>", "two", "to", "four", "WW", "domains", "a", "C0077678#ent", "<e2>"], "h": {"id": "C1414515", "name": "C1414515#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [22, 23]}}
{"token": ["We", "show", "forced", "expression", "of", "C0908880#ent", "<e1>", "causes", "absence", "of", "retinoic", "C1539598#ent", "<e2>", "neural", "morphology", ",", "and", "decreases", "expression", "of", "neural-specific", "proteins", "MAPT", "and", "NCAM", "."], "h": {"id": "C0908880", "name": "C0908880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539598", "name": "C1539598#ent", "pos": [11, 12]}}
{"token": ["The", "expression", "of", "the", "C1136365#ent", "<e1>", "these", "channels", "is", "C1420295#ent", "<e2>", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [9, 10]}}
{"token": ["This", "suggests", "that", "the", "ER", "alone", "can", "not", "overcome", "tissue-specific", "barriers", "and", "that", "one", "or", "several", "additional", "C1136365#ent", "<e1>", "in", "mediating", "C1420295#ent", "<e2>", "expression", "of", "the", "vitellogenin", "genes"], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [21, 22]}}
{"token": ["Reduction", "in", "C1832661#ent", "<e1>", "uptake", "of", "C1413950#ent", "<e2>", "by", "treatment", "with", "3.2", "%", "reactivated", "carbon", "increased", "to", "99", "%", "after", "26", "months", "of", "treatment", "."], "h": {"id": "C1832661", "name": "C1832661#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413950", "name": "C1413950#ent", "pos": [6, 7]}}
{"token": ["The", "inhibition", "of", "HDAC", "C3540790#ent", "<e1>", "by", "C1512474#ent", "<e2>", "shifts", "the", "balance", "between", "the", "deacetylation", "activity", "of", "HDAC", "C3540790#ent", "<e1>", "and", "the", "acetylation", "activity", "histone", "acetyltransferases", "resulting", "in", "hyperacetylation", "of", "core", "histones"], "h": {"id": "C1512474", "name": "C1512474#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [4, 5]}}
{"token": ["Both", "surgical", "intervention", "the", "use", "of", "C0038317#ent", "<e1>", "recommended", "in", "the", "treatment", "of", "allergic", "C0037199#ent", "<e2>"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [14, 15]}}
{"token": ["Vero", "cells", "transfected", "with", "the", "C0017337#ent", "<e1>", "encoding", "the", "surface", "antigen", "HBsAg", ")", "of", "the", "hepatitis", "B", "virus", "C0019163#ent", "<e2>", ")", "synthesize", "HBsAg", "at", "low", "levels"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "recent", "data", "from", "our", "group", "have", "suggested", "that", "in", "these", "structures", ",", "COX-2", "is", "anti-inflammatory", "at", "the", "level", "of", "cellular", "proliferation", "C1332871#ent", "<e1>", "expression", ",", "and", "C1333196#ent", "<e2>", "release", "."], "h": {"id": "C1332871", "name": "C1332871#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [28, 29]}}
{"token": ["Teicoplanin", "is", "effective", "and", "safe", "in", "C0038166#ent", "<e1>", "endocarditis", ",", "osteomyelitis", "and", "C1692886#ent", "<e2>"], "h": {"id": "C0038166", "name": "C0038166#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1692886", "name": "C1692886#ent", "pos": [12, 13]}}
{"token": ["Epinephrine", "neuronal", "systems", "play", "a", "part", "in", "some", "pharmacologic", "actions", "of", "C0026457#ent", "<e1>", "uptake", "inhibitors", "as", "well", "as", "alpha", "and", "C2987634#ent", "<e2>", "antagonists", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [20, 21]}}
{"token": ["Comparison", "of", "the", "two", "C0013227#ent", "<e1>", "that", "the", "reduction", "in", "stroke", "rate", "on", "C0004975#ent", "<e2>", "was", "greater", "than", "that", "on", "propranolol", "(", "p", "=", "0.002", ")", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004975", "name": "C0004975#ent", "pos": [13, 14]}}
{"token": ["Four", "C0013227#ent", "<e1>", "banned", "in", "sport", "(", "amiloride", ",", "triamterene", ",", "C0004975#ent", "<e2>", "and", "bumetanide", ")", "have", "been", "separated", "by", "capillary", "zone", "electrophoresis", "CZE", ")", "and", "detected", "using", "conventional", "fluorescence", "spectrometry"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004975", "name": "C0004975#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "effects", "of", "exogenous", "ET-1", "on", "the", "pulmonary", "and", "systemic", "vasculature", "patients", "with", "left", "ventricular", "systolic", "dysfunction", "C3810599#ent", "<e1>", ")", ",", "with", "or", "without", "overt", "C0018801#ent", "<e2>"], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [27, 28]}}
{"token": ["In", "this", "study", ",", "stimulation", "of", "cultured", "smooth", "muscle", "cells", "5-hydroxytryptamine", "(", "5-HT", ")", "induced", "C1418259#ent", "<e1>", "phosphorylation", "at", "Thr-423", "(", "an", "indication", "of", "C1505379#ent", "<e2>", "PAK", ")", "activation", ")", "."], "h": {"id": "C1418259", "name": "C1418259#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1505379", "name": "C1505379#ent", "pos": [24, 25]}}
{"token": ["Increased", "expression", "of", "their", "downstream", "targets", "(", "c-Myc", ",", "Bcl-xL", ",", "IL-6", ",", "LIF", ",", "C1426208#ent", "<e1>", ",", "SOCS-3", ",", "VEGF", ",", "and", "C1565860#ent", "<e2>", ")", "was", "also", "observed", "."], "h": {"id": "C1426208", "name": "C1426208#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [23, 24]}}
{"token": ["Patients", "with", "Chediak-Higashi", "syndrome", "with", "C0162429#ent", "<e1>", "displayed", "partial", "processing", "of", "C0291573#ent", "<e2>", ",", "excluding", "the", "involvement", "of", "granule", "exocytosis", "for", "the", "delivery", "of", "the", "serine", "protease", "cause", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "sulfatase", "activities", "placental", "sulfatase", "deficiency", "PSD", ")", "and", "C0020757#ent", "<e1>", "patients", "including", "ichthyosis", "vulgaris", "IV", ")", "and", "C0079588#ent", "<e2>", "RXLI", ")", "were", "analysed", "and", "were", "compared", "with", "normal", "subjects"], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C0079588", "name": "C0079588#ent", "pos": [20, 21]}}
{"token": ["The", "results", "appear", "to", "indicate", "that", "the", "imbalance", "of", "T-cell", "subsets", "the", "increase", "of", "C0879590#ent", "<e1>", "production", "may", "be", "related", "to", "the", "augmenting", "effect", "of", "C0085752#ent", "<e2>", "administration", "on", "cytotoxic", "response", "cancer", "patients", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [25, 26]}}
{"token": ["Mutation", "of", "residues", "Thr(453", ")", "and", "Thr(739", ")", "in", "Sp1", "(", "C3539947#ent", "<e1>", "phosphorylated", "by", "C1705791#ent", "<e2>", ")", "blocked", "FGF-2", "repression", "of", "PDGFR-alpha", "transcription"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [15, 16]}}
{"token": ["Three", "days", "later", "he", "developed", "C0011991#ent", "<e1>", "sigmoidoscopy", "showed", "C0033247#ent", "<e2>"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033247", "name": "C0033247#ent", "pos": [9, 10]}}
{"token": ["C0066350#ent", "<e1>", "from", "a", "C0007428#ent", "<e2>", "K-deficient", "individual", ",", "however", ",", "retained", "the", "ability", "to", "express", ",", "process", ",", "and", "secrete", "cathepsins", "L", "S", ",", "and", "displayed", "normal", "elastin-degrading", "activity", "."], "h": {"id": "C0066350", "name": "C0066350#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007428", "name": "C0007428#ent", "pos": [4, 5]}}
{"token": ["Importantly", ",", "significant", "reduction", "in", "C1417739#ent", "<e1>", "observed", "in", "C3811116#ent", "<e2>", "mice", "compared", "with", "nontransgenic", "mice"], "h": {"id": "C1417739", "name": "C1417739#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811116", "name": "C3811116#ent", "pos": [9, 10]}}
{"token": ["The", "increase", "in", "inflammatory", "cell", "content", "of", "the", "bronchial", "lavage", "fluid", "mainly", "macrophages", ",", "observed", "in", "SM-intoxicated", "guinea", "pigs", "was", "accompanied", "by", "an", "increase", "in", "C1412332#ent", "<e1>", "and", "in", "C1334523#ent", "<e2>", "activity", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1334523", "name": "C1334523#ent", "pos": [29, 30]}}
{"token": ["Nifurtimox", "(", "C0027328#ent", "<e1>", ")", "(", "4(5-nitrofurfurylidene)amino)-3-methylthiomorpholine-1", ",", "1-dioxide", ")", "is", "a", "C0013227#ent", "<e2>", "used", "against", "Chagas'", "disease", "a", "parasitic", "sickness", "several", "million", "Latin", "Americans"], "h": {"id": "C0027328", "name": "C0027328#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["C0017887#ent", "<e1>", "delivered", "by", "transdermal", "patch", "technology", "been", "used", "in", "C0002962#ent", "<e2>", "patients", "as", "well", "as", "in", "heart", "failure"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [10, 11]}}
{"token": ["Anti-GAD", "autoantibodies", "result", "in", "excess", "excitatory", "neurotransmitters", "leading", "to", "the", "C0036572#ent", "<e1>", "and", "other", "symptoms", "observed", "in", "patients", "with", "C0751383#ent", "<e2>"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0751383", "name": "C0751383#ent", "pos": [19, 20]}}
{"token": ["A", "7-year-old", "child", "with", "a", "history", "of", "C0036572#ent", "<e1>", ",", "psychomotor", "regression", "and", "progressive", "visual", "loss", "found", "to", "have", "C0751383#ent", "<e2>", "lipofuscinosis", "on", "the", "basis", "of", "characteristic", "ophthalmoscopic", "and", "electroretinographic", "findings", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0751383", "name": "C0751383#ent", "pos": [19, 20]}}
{"token": ["The", "interaction", "of", "sphingosine", "(", "SP", ")", "and", "C0075209#ent", "<e1>", "(", "SA", ")", "with", "C0216971#ent", "<e2>", "(", "DPPS", ")", "has", "been", "studied", "by", "using", "differential", "scanning", "calorimetry", "DSC", ")", "and", "phosphorus", "nuclear", "magnetic", "resonance", "31P-NMR", ")", "."], "h": {"id": "C0075209", "name": "C0075209#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0216971", "name": "C0216971#ent", "pos": [14, 15]}}
{"token": ["The", "expression", "of", "C1416599#ent", "<e1>", "was", "higher", "in", "the", "right", "atrium", "in", "other", "cardiac", "chambers", "C3811165#ent", "<e2>", "was", "expressed", "more", "in", "atria", "than", "in", "ventricles", "and", "TREK-1", "was", "highly", "expressed", "in", "the", "right", "ventricle"], "h": {"id": "C1416599", "name": "C1416599#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811165", "name": "C3811165#ent", "pos": [15, 16]}}
{"token": ["To", "study", "the", "inflammatory", "cytokine", "profile", "children", "with", "severe", "C1175175#ent", "<e1>", "SARS", ")", "and", "to", "investigate", "whether", "monoclonal", "antibody", "tumor", "necrosis", "factor-alpha", "C0812246#ent", "<e2>", ")", "could", "be", "considered", "for", "treatment", "of", "these", "patients", "."], "h": {"id": "C1175175", "name": "C1175175#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [22, 23]}}
{"token": ["RSV", "infection", "of", "alveolar", "epithelial", "cells", "induced", "increased", "phosphorylation", "and", "catalytic", "activity", "ERK", "and", "the", "upstream", "kinases", "C0812215#ent", "<e1>", "and", "MAP", "C0257151#ent", "<e2>"], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [17, 18]}, "relation": "exhibited_by", "t": {"id": "C0257151", "name": "C0257151#ent", "pos": [21, 22]}}
{"token": ["A", "mechanism", "for", "the", "generation", "of", "these", "signals", "is", "proposed", "which", "invokes", "reduction", "of", "the", "pterin", "ring", "the", "C0066697#ent", "<e1>", "to", "GMP", "from", "the", "C0030049#ent", "<e2>", "to", "the", "tetrahydro", "state", "."], "h": {"id": "C0066697", "name": "C0066697#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030049", "name": "C0030049#ent", "pos": [24, 25]}}
{"token": ["In", "this", "review", "of", "the", "therapy", "of", "infectious", "diseases", "C0751871#ent", "<e1>", "we", "summarized", "the", "latest", "reports", "of", "C0013227#ent", "<e2>", "immunosuppressants", ",", "immuno-modulatory", "and", "anti-inflammatory", "agents"], "h": {"id": "C0751871", "name": "C0751871#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["It", "was", "found", "that", "C0086130#ent", "<e1>", "and", "R-2-HMP", "could", "prevent", "ara", "C1332322#ent", "<e2>", "an", "EC50", "around", "10(-9", ")", "M", "but", "could", "not", "prevent", "low", "K+-induced", "apoptosis", "."], "h": {"id": "C0086130", "name": "C0086130#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332322", "name": "C1332322#ent", "pos": [11, 12]}}
{"token": ["Among", "neurolipidosis", "C0023522#ent", "<e1>", "the", "commonest", ",", "followed", "by", "Krabbe's", "disease", "C0039373#ent", "<e2>", "Gaucher", "disease"], "h": {"id": "C0023522", "name": "C0023522#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039373", "name": "C0039373#ent", "pos": [11, 12]}}
{"token": ["Neither", "C0543495#ent", "<e1>", "nor", "yohimbine", ",", "however", ",", "significantly", "increased", "joint", "injury", "the", "C0003864#ent", "<e2>", "rats", ",", "presumably", "because", "arthritis", "severity", "is", "already", "high", "in", "these", "animals", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [13, 14]}}
{"token": ["C0030863#ent", "<e1>", "is", "an", "antimicrobial", "drug", "intravenously", "used", "in", "the", "treatment", "of", "C0041227#ent", "<e2>", ",", "leishmaniasis", "or", "pneumocystis", "pneumonia"], "h": {"id": "C0030863", "name": "C0030863#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0041227", "name": "C0041227#ent", "pos": [12, 13]}}
{"token": ["To", "assess", "the", "possible", "relationship", "between", "treatment", "with", "selective", "serotonin-reuptake", "inhibitors", "C0360105#ent", "<e1>", ")", "and", "the", "occurrence", "of", "C0028734#ent", "<e2>", "."], "h": {"id": "C0360105", "name": "C0360105#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0028734", "name": "C0028734#ent", "pos": [18, 19]}}
{"token": ["The", "erect", "stage", "was", "induced", "with", "the", "local", "administration", "C0700461#ent", "<e1>", "and", "the", "C0026837#ent", "<e2>", "electrostimulation", "of", "the", "ischiocavernous", "muscle", "the", "erect", "stage", "."], "h": {"id": "C0700461", "name": "C0700461#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [13, 14]}}
{"token": ["The", "cause", "of", "the", "fever", ",", "C0000737#ent", "<e1>", "gradual", "cachectization", "was", "an", "abdominal", "form", "C0001261#ent", "<e2>", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001261", "name": "C0001261#ent", "pos": [14, 15]}}
{"token": ["C2744579#ent", "<e1>", "gamma", "S", "inhibits", "this", "reaction", ",", "indicating", "that", "C4284635#ent", "<e2>", "transport", "is", "C2744579#ent", "<e1>", "driven", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4284635", "name": "C4284635#ent", "pos": [10, 11]}}
{"token": ["Congenital", "isolated", "thyroid-stimulating", "hormone", "TSH", ")", "deficiency", "is", "an", "C3899988#ent", "<e1>", "manifests", "as", "C3665349#ent", "<e2>", "(", "cretinism", ")", ",", "causing", "severe", "mental", "and", "growth", "retardations"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [13, 14]}}
{"token": ["Yet", ",", "in", "addition", "to", "its", "value", "in", "producing", "C0034861#ent", "<e1>", "insect", "cells", "larvae", ",", "this", "C1520007#ent", "<e2>", "to", "evolve", "in", "new", "and", "unexpected", "ways", "."], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1520007", "name": "C1520007#ent", "pos": [16, 17]}}
{"token": ["In", "N2A", "neuroblasts", "serum", "and", "H2O2", "exhibited", "different", "kinetics", "of", "regulation", "for", "the", "Ser/Thr", "kinases", "Akt", "and", "C1415321#ent", "<e1>", "GSK-3beta", ")", "and", "for", "the", "transcription", "factor", "C1709127#ent", "<e2>", ",", "which", "governs", "redox", "homeostasis"], "h": {"id": "C1415321", "name": "C1415321#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1709127", "name": "C1709127#ent", "pos": [26, 27]}}
{"token": ["Comparative", "studies", "up", "to", "3", "months", "'", "duration", "suggest", "that", "nicorandil", "is", "equivalent", "in", "efficacy", "to", "isosorbide", "dinitrate", "propranolol", ",", "C0004147#ent", "<e1>", ",", "nifedipine", "or", "diltiazem", "in", "the", "treatment", "of", "C0002965#ent", "<e2>"], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [30, 31]}}
{"token": ["These", "are", ":", "C1561643#ent", "<e1>", "hypoparathyroidism", ",", "hypocalcemic", "D-resistant", "rickets", "senile", "or", "C0029458#ent", "<e2>"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [12, 13]}}
{"token": ["We", "have", "now", "cloned", "a", "second", "C2987130#ent", "<e1>", "encoding", "macroH2A2", "which", "shares", "80", "%", "amino", "acid", "identity", "with", "C3814450#ent", "<e2>", "."], "h": {"id": "C2987130", "name": "C2987130#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3814450", "name": "C3814450#ent", "pos": [18, 19]}}
{"token": ["Bactericidal/permeability-increasing", "protein", "BPI", ")", "is", "an", "antineutrophil", "cytoplasmic", "autoantibody", "C1414527#ent", "<e1>", ")", "target", "antigen", "in", "C0010346#ent", "<e2>", "IBD", ")", "."], "h": {"id": "C1414527", "name": "C1414527#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [15, 16]}}
{"token": ["This", "study", "was", "done", "to", "determine", "the", "effects", "of", "hyperglycemia", "or", "C0020616#ent", "<e1>", "on", "brain", "cell", "membrane", "function", "energy", "metabolism", "the", "immediate", "reoxygenation-reperfusion", "period", "after", "C0178540#ent", "<e2>", "(", "HI", ")", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0178540", "name": "C0178540#ent", "pos": [25, 26]}}
{"token": ["Our", "results", "suggest", "that", "T54", "phosphorylation", "RIIalpha", "by", "C0080054#ent", "<e1>", "might", "serve", "to", "regulate", "the", "centrosomal", "association", "of", "C0010531#ent", "<e2>", "during", "the", "cell", "cycle"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [18, 19]}}
{"token": ["Dominant", "C0338508#ent", "<e1>", "type", "Kjer", "is", "an", "C2936739#ent", "<e2>", "eye", "disease", "is", "characterized", "by", "progressive", "C0338508#ent", "<e1>", "onset", "in", "early", "childhood", "decrease", "of", "visual", "acuity", "colour", "vision", "defects", "centrocecal", "scotoma"], "h": {"id": "C0338508", "name": "C0338508#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [7, 8]}}
{"token": ["Dominant", "optic", "atrophy", "C0338508#ent", "<e1>", "is", "an", "C2936739#ent", "<e2>", "eye", "disease", "is", "characterized", "by", "progressive", "optic", "atrophy", "onset", "in", "early", "childhood", "decrease", "of", "visual", "acuity", "colour", "vision", "defects", "centrocecal", "scotoma"], "h": {"id": "C0338508", "name": "C0338508#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [7, 8]}}
{"token": ["These", "include", "primary", "and", "diffuse", "hypoxic", "brain", "injury", ",", "intracranial", "hematomas", "C0007785#ent", "<e1>", "infarction", ",", "and", "C0549423#ent", "<e2>"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0549423", "name": "C0549423#ent", "pos": [16, 17]}}
{"token": ["The", "acute", "phase", "a", "C0007785#ent", "<e1>", "become", "complicated", "with", "C0549423#ent", "<e2>", "subsequent", "intracranial", "hypertension", "and", "the", "need", "for", "surgical", "management"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0549423", "name": "C0549423#ent", "pos": [9, 10]}}
{"token": ["Expression", "analysis", "antioxidant", "enzymes", "that", "autocrine", "hGH", "increased", "both", "the", "mRNA", "and", "protein", "levels", "catalase", ",", "superoxide", "dismutase", "1", "SOD1", ")", ",", "glutathione", "peroxidase", "C0017037#ent", "<e1>", "not", "that", "of", "C1826449#ent", "<e2>", "."], "h": {"id": "C0017037", "name": "C0017037#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1826449", "name": "C1826449#ent", "pos": [29, 30]}}
{"token": ["After", "addition", "of", "these", "probes", "to", "platelet", "suspensions", "37", "degrees", "C", ",", "the", "fluorescence", "intensity", "C0044182#ent", "<e1>", "reached", "equilibrium", "within", "2", "min", ",", "whereas", "those", "of", "C0031507#ent", "<e2>", "and", "TMA-DPH", "increased", "gradually", "."], "h": {"id": "C0044182", "name": "C0044182#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [26, 27]}}
{"token": ["This", "article", "serves", "as", "a", "review", "of", "the", "most", "widely", "published", "associations", "between", "C0037274#ent", "<e1>", "specific", "subtypes", "of", "C0042721#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [18, 19]}}
{"token": ["In", "C0003289#ent", "<e1>", ",", "most", "drugs", "are", "metabolized", "via", "the", "polymorphic", "cytochrome", "P450", "enzyme", "C1332830#ent", "<e2>", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1332830", "name": "C1332830#ent", "pos": [14, 15]}}
{"token": ["Our", "findings", "show", "that", "a", "minute", "amount", "of", "C0022471#ent", "<e1>", "directly", "to", "the", "entorhinal", "cortex", "unanesthetized", "animals", "reliably", "produces", "C0234533#ent", "<e2>", "well", "as", "a", "consistent", "pattern", "of", "cell", "damage", "the", "hippocampus", "."], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [19, 20]}}
{"token": ["C0017923#ent", "<e1>", "HD", ")", "is", "one", "of", "the", "major", "C0009450#ent", "<e2>", "the", "world", "with", "an", "estimated", "total", "of", "12", "million", "cases", "."], "h": {"id": "C0017923", "name": "C0017923#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [9, 10]}}
{"token": ["A", "case", "is", "reported", "of", "common", "variable", "immunodeficiency", "C0009447#ent", "<e1>", ")", "presenting", "as", "an", "C0518958#ent", "<e2>", "to", "Mycoplasma", "hominis"], "h": {"id": "C0009447", "name": "C0009447#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0518958", "name": "C0518958#ent", "pos": [14, 15]}}
{"token": ["Five", "min", "after", "dry", "air", "challenge", "C2699119#ent", "<e1>", "initially", "increased", "114", "+", "/-", "C1414863#ent", "<e2>", "22", "%", ";", "contralateral", "control", "segments", "unchanged", "(", "n", "=", "9", ")", "."], "h": {"id": "C2699119", "name": "C2699119#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [13, 14]}}
{"token": ["C3272717#ent", "<e1>", ",", "also", "called", "Tudor-SN", "and", "C1822796#ent", "<e2>", "and", "recently", "reported", "to", "be", "a", "component", "of", "RISC", ",", "is", "among", "the", "list", "of", "highly", "expressed", "genes", "in", "human", "colon", "cancers"], "h": {"id": "C3272717", "name": "C3272717#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1822796", "name": "C1822796#ent", "pos": [7, 8]}}
{"token": ["The", "efficacy", "of", "intravenous", "C0031507#ent", "<e1>", "for", "the", "treatment", "of", "C0038220#ent", "<e2>", "related", "to", "the", "rapid", "entry", "of", "C0031507#ent", "<e1>", "into", "brain", "parenchyma"], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [10, 11]}}
{"token": ["The", "principal", "polyunsaturated", "fatty", "acids", "the", "ethanolamine", "and", "C2932888#ent", "<e1>", "brain", ",", "liver", ",", "and", "yolk", "were", "C2348308#ent", "<e2>", ",", "20:4", ",", "and", "18:2", ",", "respectively", "."], "h": {"id": "C2932888", "name": "C2932888#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2348308", "name": "C2348308#ent", "pos": [17, 18]}}
{"token": ["The", "ribonucleoprotein", "complex", "is", "involved", "in", "the", "packaging", "and", "annealing", "of", "tRNALys", "into", "HIV-1", "consists", "of", "C0017346#ent", "<e1>", ",", "GagPol", ",", "tRNALys", ",", "C1416540#ent", "<e2>", "LysRS", ")", ",", "and", "viral", "genomic", "RNA"], "h": {"id": "C0017346", "name": "C0017346#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416540", "name": "C1416540#ent", "pos": [23, 24]}}
{"token": ["Prevalence", "of", "C0520679#ent", "<e1>", "is", "also", "reported", "in", "allergic", "diseases", "C1334103#ent", "<e2>", "asthma", "and", "atopic", "dermatitis"], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334103", "name": "C1334103#ent", "pos": [10, 11]}}
{"token": ["C0949646#ent", "<e1>", "is", "classified", "as", "type", "I", "C0086669#ent", "<e2>", "or", "type", "II", "myosin", "II", "."], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086669", "name": "C0086669#ent", "pos": [7, 8]}}
{"token": ["Actin", ",", "villin", ",", "C0949646#ent", "<e1>", ",", "tropomyosin", "and", "spectrin", ",", "but", "not", "C0086669#ent", "<e2>", "previously", "called", "110", "kD", ";", "see", "Mooseker", "and", "Coleman", ",", "J.", "Cell", "Biol", "."], "h": {"id": "C0949646", "name": "C0949646#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086669", "name": "C0086669#ent", "pos": [13, 14]}}
{"token": ["By", "the", "second", "day", "of", "treatment", ",", "C0169307#ent", "<e1>", "evoked", "a", "15-fold", "increase", "in", "PCNA", "expression", ",", "and", "C0038633#ent", "<e2>", "produced", "an", "11.8-fold", "enhancement", "."], "h": {"id": "C0169307", "name": "C0169307#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038633", "name": "C0038633#ent", "pos": [18, 19]}}
{"token": ["Accelerated", "ulcer", "healing", "C0169307#ent", "<e1>", "(", "7", "days", ")", "and", "C0038633#ent", "<e2>", "(", "8", "days", ")", "treatments", "was", "reflected", "in", "a", "significant", "enhancement", "of", "PCNA", "and", "Cdk2", "expression", "."], "h": {"id": "C0169307", "name": "C0169307#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038633", "name": "C0038633#ent", "pos": [10, 11]}}
{"token": ["The", "CO-mediated", "cytoprotective", "effects", "nitric", "oxide", "C0132555#ent", "<e1>", "and", "cyclic", "guanine", "monophosphate-independent", "but", "C1456378#ent", "<e2>", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [13, 14]}}
{"token": ["No", "interference", "C0012695#ent", "<e1>", ",", "SAD", ",", "DMSO", ",", "or", "C0030883#ent", "<e2>", "was", "noticed", "on", "the", "RIA", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "the", "structural", "links", "between", "the", "peripheral", "lamina", "the", "internal", "nuclear", "matrix", "are", "thought", "to", "be", "mediated", "by", "LAP2", "family", "members", "filament", "protein", "C1420877#ent", "<e1>", "and", "nucleoporin", "C1417892#ent", "<e2>", "."], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1417892", "name": "C1417892#ent", "pos": [28, 29]}}
{"token": ["When", "C1418641#ent", "<e1>", "and", "PLD2", "were", "C3889446#ent", "<e2>", ",", "PLD2", "potently", "caused", "a", "decrease", "in", "melanin", "content", ",", "whereas", "the", "effect", "of", "C1418641#ent", "<e1>", "expression", "on", "melanin", "content", "minimal", "."], "h": {"id": "C1418641", "name": "C1418641#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [6, 7]}}
{"token": ["The", "Escherichia", "coli", "enzyme", "purine", "nucleoside", "phosphorylase", "C1418856#ent", "<e1>", ")", "gene", "is", "delivered", "directly", "into", "C1366526#ent", "<e2>", "one", "injection", "of", "replication-deficient", "human", "type-5", "adenovirus", "(", "Ad5", ")", "."], "h": {"id": "C1418856", "name": "C1418856#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [15, 16]}}
{"token": ["C0909868#ent", "<e1>", "protein", "was", "increased", "1.6-fold", "by", "C0002502#ent", "<e2>", "."], "h": {"id": "C0909868", "name": "C0909868#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [7, 8]}}
{"token": ["Our", "data", "suggest", "that", "these", "enzymes", "act", "on", "their", "own", ",", "and", "additional", "C1305923#ent", "<e1>", "are", "not", "involved", "in", "recognizing", "C1418237#ent", "<e2>", "as", "a", "substrate", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418237", "name": "C1418237#ent", "pos": [20, 21]}}
{"token": ["By", "immunolabeling", "of", "cryosections", ",", "we", "have", "characterized", "in", "rat", "cardiac", "myocytes", "cation-independent", "mannose-6-phosphate", "receptor", "MPR", ")", ",", "a", "lysosomal", "membrane", "glycoprotein", "C3540818#ent", "<e1>", ",", "and", "a", "lysosomal", "enzyme", "C1707163#ent", "<e2>", "(", "homologous", "to", "cathepsin", "L", "."], "h": {"id": "C3540818", "name": "C3540818#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1707163", "name": "C1707163#ent", "pos": [29, 30]}}
{"token": ["Two", "health", "problems", "reported", "by", "all", "women", ":", "mental", "tension", "to", "C0270697#ent", "<e1>", "and", "white", "vaginal", "discharge", "to", "C0741585#ent", "<e2>", "fatigue", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0741585", "name": "C0741585#ent", "pos": [18, 19]}}
{"token": ["Elicited", "macrophages", "and", "splenic", "macrophages", "C57Bl/6", "mice", "unlike", "those", "from", "BALB/c", "mice", "did", "not", "respond", "to", "10(-15)-10(-8", ")", "M", "C0044549#ent", "<e1>", "or", "PAF", "without", "or", "with", "C0175697#ent", "<e2>", "."], "h": {"id": "C0044549", "name": "C0044549#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [26, 27]}}
{"token": ["The", "results", "of", "the", "study", "show", "significant", "associations", "between", "the", "state", "of", "being", "uncircumcised", "and", "four", "major", "sexually", "transmissible", "diseases", "herpes", "genitalis", "C0006840#ent", "<e1>", ",", "gonorrhoea", "and", "C0153188#ent", "<e2>", "."], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0153188", "name": "C0153188#ent", "pos": [27, 28]}}
{"token": ["We", "describe", "a", "patient", "who", "developed", "C1527353#ent", "<e1>", "after", "a", "mild", "inflammatory", "arthritis", "in", "association", "with", "a", "number", "of", "C0037274#ent", "<e2>", "including", "hypertrichosis", "."], "h": {"id": "C1527353", "name": "C1527353#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [19, 20]}}
{"token": ["distemper", ",", "C0014335#ent", "<e1>", "botulism", ",", "pseudomonas", "infection", "fox", ":", "C0023364#ent", "<e2>", ",", "distemper", ",", "fox", "encephalitis", "ocelot", ":", "panleukopenia", ";", "chinchilla", ":", "pseudomonas", "infection", "coli", "infection", "yersinia", "infection"], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023364", "name": "C0023364#ent", "pos": [10, 11]}}
{"token": ["significantly", "increased", "the", "ED,5", "(", "dose", "to", "evoke", "a", "15", "%", "fall", "in", "C3813197#ent", "<e1>", ")", "values", "for", "C0936268#ent", "<e2>", "and", "Ro", "31", "-", "6930", "."], "h": {"id": "C3813197", "name": "C3813197#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0936268", "name": "C0936268#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "C0026936#ent", "<e1>", "reduced", "the", "expression", "level", "and", "inducibility", "of", "an", "endogenous", "C1854597#ent", "<e2>", "p21(waf1", ")", ",", "and", "inhibited", "apoptosis", "induced", "by", "genotoxic", "stress"], "h": {"id": "C0026936", "name": "C0026936#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1854597", "name": "C1854597#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "C1333246#ent", "<e1>", "promotes", "adipocyte", "hypertrophy", "counteracting", "the", "inhibitory", "effect", "of", "C0752312#ent", "<e2>", "on", "PPAR-gamma", "and", "may", "thus", "confer", "predisposition", "to", "diet-induced", "obesity", "."], "h": {"id": "C1333246", "name": "C1333246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [14, 15]}}
{"token": ["MAPKK", "kinase/MEKK", "phosphorylates", "and", "activates", "its", "C1333246#ent", "<e1>", "MAPK", "kinase/MEK", ",", "which", "in", "turn", "activates", "C0752312#ent", "<e2>", "."], "h": {"id": "C1333246", "name": "C1333246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [15, 16]}}
{"token": ["The", "enzyme-extracting", "medium", "contained", "insoluble", "polyvinylpyrrolidone", ",", "and", "including", "dithiothreitol", "or", "C0207481#ent", "<e1>", "did", "not", "improve", "C0014442#ent", "<e2>", "recovery", "."], "h": {"id": "C0207481", "name": "C0207481#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "C0020625#ent", "<e1>", "salt", "intake", "separate", "subpopulations", "of", "neurons", "in", "the", "C1417869#ent", "<e2>", ",", "which", "then", "transmit", "this", "information", "to", "the", "forebrain", "via", "largely", "separate", "relay", "nuclei", "in", "the", "PB", "complex", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [12, 13]}}
{"token": ["A", "Phase", "III", "trial", "C0935902#ent", "<e1>", ",", "a", "broad-spectrum", "MMPI", "in", "combination", "with", "paclitaxel", "and", "C0079083#ent", "<e2>", "is", "open", "for", "patients", "with", "advanced", "NSCLC", "."], "h": {"id": "C0935902", "name": "C0935902#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [15, 16]}}
{"token": ["In", "addition", "to", "activity", "against", "azocasein", ",", "the", "purified", "protease", "exhibits", "activity", "against", "azocoll", "and", "insoluble", "C0007332#ent", "<e1>", "but", "not", "C1414382#ent", "<e2>", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [20, 21]}}
{"token": ["The", "activator", "did", "not", "show", "any", "activity", "towards", "collagen", ",", "gelatin", ",", "C0007332#ent", "<e1>", ",", "haemoglobin", ",", "histones", ",", "C1414382#ent", "<e2>", "or", "p-phenylazobenzyloxycarbonyl-peptide", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [19, 20]}}
{"token": ["C0007332#ent", "<e1>", ",", "bovine", "serum", "albumin", "ovalbumin", ",", "beta-lactoglobulin", ",", "and", "C1414382#ent", "<e2>", "were", "digested", "by", "the", "protease", "while", "collagen", "and", "keratin", "were", "resistant", "to", "digestion", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [11, 12]}}
{"token": ["C0039007#ent", "<e1>", "and", "lymphangitis", "are", "frequent", "complications", "of", "C3852998#ent", "<e2>", "(", "20", "to", "30", "%", ")", "."], "h": {"id": "C0039007", "name": "C0039007#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3852998", "name": "C3852998#ent", "pos": [8, 9]}}
{"token": ["The", "present", "study", "was", "performed", "to", "determine", "whether", "corticosteroid", "therapy", "effective", "in", "preventing", "delayed", "C0031065#ent", "<e1>", "in", "children", "with", "C3890018#ent", "<e2>", "."], "h": {"id": "C0031065", "name": "C0031065#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [19, 20]}}
{"token": ["However", ",", "the", "effects", "of", "C0168388#ent", "<e1>", "on", "specific", "symptoms", "of", "anxiety", ",", "agitation", ",", "and", "C0917801#ent", "<e2>", "have", "not", "been", "reported", "."], "h": {"id": "C0168388", "name": "C0168388#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0917801", "name": "C0917801#ent", "pos": [16, 17]}}
{"token": ["Peptide-N4-(N-acetyl-beta-D-glucosaminyl", ")", "asparagine", "amidases", "PNGase", ")", "and", "endo-N-acetyl-beta-D-glucosaminidases", "(", "C2681929#ent", "<e1>", ")", "were", "both", "considered", "as", "de-N-glycosylation", "C3541394#ent", "<e2>", "."], "h": {"id": "C2681929", "name": "C2681929#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "pharmacokinetics", "of", "single", "and", "multiple", "doses", "C0936072#ent", "<e1>", "horses", "and", "to", "evaluate", "prophylactic", "efficacy", "of", "rimantadine", "in", "C0021400#ent", "<e2>", "virus-infected", "horses", "."], "h": {"id": "C0936072", "name": "C0936072#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [19, 20]}}
{"token": ["In", "the", "lateral", "hypothalamic", "area", "hypocretin/orexin", "neurons", "express", "C1424493#ent", "<e1>", "or", "VGLUT2", ",", "but", "not", "GAD", ",", "whereas", "some", "C1418669#ent", "<e2>", "MCH", ")", "cells", "contain", "GAD", "."], "h": {"id": "C1424493", "name": "C1424493#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418669", "name": "C1418669#ent", "pos": [19, 20]}}
{"token": ["We", "report", "on", "two", "patients", ",", "treated", "with", "C0015772#ent", "<e1>", "and", "nifedipine", "for", "C0020538#ent", "<e2>", "who", "presented", "with", "an", "exacerbation", "of", "their", "myasthenia", "gravis", "a", "myasthenic", "syndrome", "exacerbation", "of", "myasthenia", "gravis", "respectively", "."], "h": {"id": "C0015772", "name": "C0015772#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [13, 14]}}
{"token": ["Prospective", "blinded", "efficacy", "studies", "of", "the", "C0012544#ent", "<e1>", "in", "the", "treatment", "of", "C0029899#ent", "<e2>", "should", "be", "undertaken", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029899", "name": "C0029899#ent", "pos": [12, 13]}}
{"token": ["The", "rationale", "for", "use", "of", "C0012544#ent", "<e1>", "to", "treat", "the", "sensorineural", "hearing", "loss", "C0029899#ent", "<e2>", "is", "explained", ",", "with", "cases", "that", "illustrate", "the", "bisphosphonates", "treatment", "algorithms", "and", "the", "response", "to", "treatment", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029899", "name": "C0029899#ent", "pos": [13, 14]}}
{"token": ["As", "a", "first", "step", "to", "exploit", "the", "potential", "of", "Trichoderma", "reesei", "produce", "hemicellulases", ",", "we", "have", "purified", "two", "endo-beta-1,4-xylanases", "(", "1,4-beta-D-xylan", "xylanohydrolase", ",", "C1567679#ent", "<e1>", "and", "cloned", "their", "C0017337#ent", "<e2>", "."], "h": {"id": "C1567679", "name": "C1567679#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [28, 29]}}
{"token": ["2", ")", "The", "appearance", "of", "the", "C1305923#ent", "<e1>", "with", "the", "activation", "of", "C0291573#ent", "<e2>", "the", "cleavage", "of", "poly(ADP-ribose)", "polymerase", "a", "known", "caspase", "substrate", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [12, 13]}}
{"token": ["This", "study", "evaluated", "the", "effect", "of", "sodium", "naproxen", "a", "reversible", "competitive", "inhibitor", "of", "C0033551#ent", "<e1>", ")", "and", "phenylephrine", "(", "a", "C0001641#ent", "<e2>", "eye", "drops", "maintaining", "atropine", "mydriasis", "the", "rabbit", "after", "paracentesis", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [20, 21]}}
{"token": ["Two", "homologous", "proteins", "C1332740#ent", "<e1>", "and", "AtdS", ",", "encoded", "by", "C0017337#ent", "<e2>", "identified", "in", "strains", "degrading", "nitrobenzene", "and", "aniline", ",", "respectively", ",", "were", "also", "purified", "and", "characterized", "."], "h": {"id": "C1332740", "name": "C1332740#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["The", "angiotensin", "II", "type", "2", "AT2", ")", "receptor", "inhibits", "basic", "fibroblast", "growth", "proliferation", "of", "R3T3", "fibroblast", "cells", "transiently", "stimulates", "a", "vanadate-sensitive", "phosphotyrosine", "phosphatase", "strongly", "suggesting", "that", "C1705845#ent", "<e1>", "is", "a", "C0026249#ent", "<e2>", "inhibitor", "."], "h": {"id": "C1705845", "name": "C1705845#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [30, 31]}}
{"token": ["Moreover", ",", "adenovirus-mediated", "overexpression", "of", "SMILE", "and", "C1334896#ent", "<e1>", "down-regulates", "estrogen-induced", "mRNA", "expression", "of", "the", "critical", "cell-cycle", "regulator", "C1705438#ent", "<e2>", "."], "h": {"id": "C1334896", "name": "C1334896#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705438", "name": "C1705438#ent", "pos": [18, 19]}}
{"token": ["Treatment", "with", "C0033640#ent", "<e1>", "PKA", ")", "activators", "[", "C0000096#ent", "<e2>", "CT/IBMX", ")", "]", "induced", "WISP-2", "expression", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000096", "name": "C0000096#ent", "pos": [8, 9]}}
{"token": ["As", "judged", "by", "immunofluorescence", "endoplasmic", "reticulum", "Golgi", "transport", "accelerated", "in", "cells", "incubated", "with", "activators", "of", "C0033640#ent", "<e1>", "as", "isobutylmethylxanthine", "(", "C0000096#ent", "<e2>", ")", "or", "forskolin", "(", "FK", ")", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0000096", "name": "C0000096#ent", "pos": [20, 21]}}
{"token": ["C0077209#ent", "<e1>", "combination", "therapy", "cisplatin", "or", "C0015133#ent", "<e2>", "was", "evaluated", "in", "non-small", "cell", "lung", "cancer", "patients", "in", "a", "pilot", ",", "dose", "escalation", "study", "."], "h": {"id": "C0077209", "name": "C0077209#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [6, 7]}}
{"token": ["Compared", "to", "subjects", "who", "met", "DSM-III-R", "criteria", "for", "C1335499#ent", "<e1>", ",", "infrequent", "panickers", "presented", "with", "fewer", "C2945698#ent", "<e2>", "fewer", "panic", "episodes", "less", "panic-related", "worry", ",", "lower", "anxiety", "sensitivity", "and", "less", "panic-related", "avoidance", "."], "h": {"id": "C1335499", "name": "C1335499#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2945698", "name": "C2945698#ent", "pos": [16, 17]}}
{"token": ["Depending", "on", "the", "patient's", "gender", ",", "the", "affected", "C0014442#ent", "<e1>", ",", "and", "the", "extent", "of", "enzymatic", "dysfunction", "symptoms", "include", "C0342492#ent", "<e2>", "androgen", "excess", "virilization", ",", "growth", "disturbance", "and", "electrolyte", "imbalance", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0342492", "name": "C0342492#ent", "pos": [19, 20]}}
{"token": ["Many", "of", "the", "C0005064#ent", "<e1>", "(", "e.g.", "alprazolam", ",", "triazolam", "and", "C0026056#ent", "<e2>", ")", "are", "metabolised", "by", "the", "cytochrome", "P450", "(CYP)3A", "subfamily"], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [11, 12]}}
{"token": ["C0005064#ent", "<e1>", ",", "such", "as", "C0026056#ent", "<e2>", "and", "lorazepam", ",", "represent", "important", "choices", "among", "drugs", "used", "for", "sedation", "in", "the", "pediatric", "ICU", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [5, 6]}}
{"token": ["Comparisons", "were", "made", "with", "pentobarbital", "and", "the", "C0005064#ent", "<e1>", ",", "lorazepam", "and", "C0026056#ent", "<e2>", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [7, 8]}, "relation": "structural_class_of", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "antioxidant", "C3272771#ent", "<e1>", "attenuated", "the", "salt-evoked", "MR", "upregulation", "and", "C1528301#ent", "<e2>", "induction", "and", "alleviated", "proteinuria", "and", "renal", "histological", "abnormalities", ",", "suggesting", "the", "involvement", "of", "oxidative", "stress", "salt-induced", "MR", "activation", "."], "h": {"id": "C3272771", "name": "C3272771#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1528301", "name": "C1528301#ent", "pos": [11, 12]}}
{"token": ["Recent", "studies", "show", "that", "luteal", "regression", "the", "rat", "can", "be", "blocked", "by", "the", "administration", "of", "C0017711#ent", "<e1>", "yet", "endogenous", "C3540778#ent", "<e2>", "are", "maximal", "at", "the", "time", "of", "normal", "luteal", "regression", "pregnancy", "."], "h": {"id": "C0017711", "name": "C0017711#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "mRNA", "for", "inhibitor-1", "(", "C1425233#ent", "<e1>", ")", ",", "an", "endogenous", "inhibitor", "of", "C1335240#ent", "<e2>", ",", "was", "detected", "only", "in", "undifferentiated", "stem", "cells", "the", "outer", "cortical", "area", "."], "h": {"id": "C1425233", "name": "C1425233#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335240", "name": "C1335240#ent", "pos": [15, 16]}}
{"token": ["Cerebrotendinous", "xanthomatosis", "CTX", ")", "is", "a", "rare", "familiar", "disease", "by", "tendon", "xanthomas", "cataracts", ",", "C0007758#ent", "<e1>", "dementia", "and", "an", "elevated", "serum", "C0238052#ent", "<e2>", "level", "."], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0238052", "name": "C0238052#ent", "pos": [21, 22]}}
{"token": ["Pharmacotherapy", "goals", "include", "the", "reduction", "of", "risk", "factors", "sleep", "apnoea", "correction", "of", "underlying", "predisposing", "C0025517#ent", "<e1>", "such", "as", "hypothyroidism", "or", "acromegaly", ";", "treatment", "of", "C0521989#ent", "<e2>", "including", "excessive", "daytime", "sleepiness", "and", "prevention", "of", "apnoeas/hypopnoeas", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0521989", "name": "C0521989#ent", "pos": [24, 25]}}
{"token": ["The", "actions", "of", "disodium", "cromproxate", "differed", "from", "those", "of", "C0033497#ent", "<e1>", ",", "as", "C0033497#ent", "<e1>", "had", "no", "antagonistic", "action", "membrane", "potential", "changes", "induced", "by", "C1705725#ent", "<e1>", "and", "PMA", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [24, 25]}}
{"token": ["However", ",", "clorgyline", "depressed", "the", "formation", "of", "C0032483#ent", "<e1>", "more", "than", "that", "of", "DOMA", ",", "while", "C0036579#ent", "<e2>", "depressed", "the", "formation", "of", "DOMA", "more", "than", "that", "of", "C0032483#ent", "<e1>", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036579", "name": "C0036579#ent", "pos": [16, 17]}}
{"token": ["One", "C0002085#ent", "<e1>", "comprises", "two", "complete", "tandem", "repeats", "a", "sequence", "encoding", "an", "C4284309#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4284309", "name": "C4284309#ent", "pos": [12, 13]}}
{"token": ["Exploiting", "C0002085#ent", "<e1>", "variation", "in", "C4284309#ent", "<e2>", ",", "we", "examined", "transcription", "of", "the", "gene", "from", "active", "and", "inactive", "mouse", "X", "in", "vivo", "in", "female", "mice", "carrying", "an", "X-autosome", "translocation"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4284309", "name": "C4284309#ent", "pos": [5, 6]}}
{"token": ["A", "cDNA", "for", "C0015625#ent", "<e1>", "group", "C", "(", "C2828029#ent", "<e2>", ")", "has", "recently", "been", "cloned", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C2828029", "name": "C2828029#ent", "pos": [8, 9]}}
{"token": ["We", "previously", "cloned", "the", "gene", "defective", "Fanconi", "anemia", "group", "C", "complementation", "of", "the", "intrinsic", "sensitivity", "of", "C0015625#ent", "<e1>", "DNA", "cross-linking", "agents", "and", "we", "recently", "cloned", "its", "mouse", "homolog", "C2828029#ent", "<e2>", ")", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [16, 17]}, "relation": "disease_has_associated_gene", "t": {"id": "C2828029", "name": "C2828029#ent", "pos": [28, 29]}}
{"token": ["In", "summary", ",", "TcdA-induced", "apoptosis", "in", "HT29", "cells", "on", "glucosylation", "of", "C0174045#ent", "<e1>", "to", "activation", "of", "C0699919#ent", "<e2>", "and", "caspase-3", "."], "h": {"id": "C0174045", "name": "C0174045#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [16, 17]}}
{"token": ["In", "the", "present", "study", "BP", "was", "measured", "before", "operation", ",", "during", "surgery", "and", "after", "operation", "in", "42", "C1442521#ent", "<e1>", "patients", "and", "in", "15", "control", "subjects", "for", "C0221777#ent", "<e2>"], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0221777", "name": "C0221777#ent", "pos": [26, 27]}}
{"token": ["It", "is", "suggested", "that", "hot", "weather", "dehydration", "and", "aggravation", "of", "C0242422#ent", "<e1>", "premenstrually", "constitute", "risk", "factors", "the", "development", "of", "C1744687#ent", "<e2>", ",", "in", "addition", "to", "withdrawal", "of", "antiparkinsonian", "drugs"], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1744687", "name": "C1744687#ent", "pos": [19, 20]}}
{"token": ["In", "C0242422#ent", "<e1>", "patients", "who", "continually", "received", "dopaminergic", "medications", "the", "development", "of", "C1744687#ent", "<e2>", "occurred", "exclusively", "in", "warm", "seasons", "May", "to", "August", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1744687", "name": "C1744687#ent", "pos": [12, 13]}}
{"token": ["These", "data", "suggest", "that", "the", "primary", "cilia", "important", "for", "normal", "renal", "function", "development", "and", "that", "the", "C0008780#ent", "<e1>", "be", "a", "contributing", "factor", "to", "the", "C2931187#ent", "<e2>", "Tg737(o)(rpk", ")", "mice", "."], "h": {"id": "C0008780", "name": "C0008780#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2931187", "name": "C2931187#ent", "pos": [24, 25]}}
{"token": ["Late", "age", "menarche", "(", "AAM", ")", ",", "an", "important", "type", "of", "C0339143#ent", "<e1>", "in", "females", ",", "is", "associated", "with", "lower", "bone", "mineral", "density", "C1826421#ent", "<e2>", ")", ",", "a", "major", "risk", "factor", "osteoporosis", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1826421", "name": "C1826421#ent", "pos": [23, 24]}}
{"token": ["C0002395#ent", "<e1>", "characterized", "by", "the", "accumulation", "of", "aggregated", "amyloid", "beta-peptide", "C1705543#ent", "<e2>", ")", "in", "the", "brain", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [10, 11]}}
{"token": ["Immunization", "of", "mouse", "models", "C0002395#ent", "<e1>", "AD", ")", "with", "amyloid-peptide", "(", "C1705543#ent", "<e2>", ")", "reduces", "Abeta", "deposits", "attenuates", "their", "memory", "and", "learning", "deficits"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [11, 12]}}
{"token": ["To", "investigate", "whether", "VAC", "compounds", "bind", "to", "the", "currently", "known", "isoforms", "C1414463#ent", "<e1>", "or", "ERss", ",", "ligand", "binding", "assays", "C1413266#ent", "<e2>", ")", "were", "performed", "."], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413266", "name": "C1413266#ent", "pos": [19, 20]}}
{"token": ["Direct", "C0281398#ent", "<e1>", "testing", "was", "performed", "in", "42", "C1861185#ent", "<e2>", "platelet", "counts", "-", "179", "x", "10(9)/l", ",", "median", "56", "x", "10(9)/l", ")", "."], "h": {"id": "C0281398", "name": "C0281398#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1861185", "name": "C1861185#ent", "pos": [8, 9]}}
{"token": ["There", "is", "not", "question", "that", "these", "compounds", "can", "induce", "constriction", "(", "C1335207#ent", "<e1>", ")", "or", "relaxation", "(", "PGE", ")", "of", "the", "smooth", "muscle", "C0006267#ent", "<e2>", "and", "pulmonary", "vessels"], "h": {"id": "C1335207", "name": "C1335207#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [23, 24]}}
{"token": ["While", "C2936739#ent", "<e1>", "C0034152#ent", "<e2>", "has", "been", "extensively", "studied", ",", "autosomal", "recessive", "C0034152#ent", "<e2>", "is", "less", "well", "known", "and", "is", "considered", "a", "rare", "condition", "."], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [3, 4]}}
{"token": ["We", "evaluated", "the", "role", "of", "nitric", "oxide", "lipid", "peroxidation", "the", "pathophysiological", "mechanisms", "of", "seizures", "in", "genetically", "epilepsy", "(", "C3539613#ent", "<e1>", ")", "rats", "and", "DBA/2", "mice", "genetically", "determined", "C0014544#ent", "<e2>"], "h": {"id": "C3539613", "name": "C3539613#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [27, 28]}}
{"token": ["Deamino-8-D-argenine", "vasopressin", "DDAVP", ")", "was", "given", "by", "intravenous", "infusion", "normal", "subjects", "haemophiliacs", "and", "patients", "with", "C0042974#ent", "<e1>", "vWd", ")", "and", "the", "factor", "VIII", "C0032144#ent", "<e2>", "studied", "."], "h": {"id": "C0042974", "name": "C0042974#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032144", "name": "C0032144#ent", "pos": [23, 24]}}
{"token": ["After", "bath", "application", "of", "C0754188#ent", "<e1>", "and", "Kyn", "or", "C0813872#ent", "<e2>", "and", "Kyn", ",", "two", "different", "responses", "were", "observed", "."], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [9, 10]}}
{"token": ["The", "NMDA", "receptor", "antagonist", "D-2-amino-5-phosphonopentanoic", "acid", "C0754188#ent", "<e1>", ";", "100", "microM", ")", "had", "effects", "similar", "to", "C0813872#ent", "<e2>", "."], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [16, 17]}}
{"token": ["Third", ",", "IE", "facilitation", "was", "diminished", "by", "applications", "of", "the", "NMDA", "glutamate", "receptor", "antagonists", "D-2-amino-5-phosphonovaleric", "acid", "(", "C0754188#ent", "<e1>", ")", "and", "dizocilpine", "(", "C0813872#ent", "<e2>", ")", "."], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [23, 24]}}
{"token": ["LTPgly", "did", "not", "involve", "NMDA", "receptor", "activation", "as", "proven", "by", "the", "lack", "of", "inhibition", "by", "100", "microM", "D", ",", "L-2-amino-5-phosphonovaleric", "acid", "C0754188#ent", "<e1>", ")", "and", "10", "microM", "C0813872#ent", "<e2>", "."], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [27, 28]}}
{"token": ["To", "describe", "a", "30-year-old", "man", "with", "bilateral", "but", "asymmetric", "anterior", "keratoconus", "and", "unilateral", "C0271288#ent", "<e1>", "the", "eye", "with", "more", "advanced", "C0022578#ent", "<e2>", "."], "h": {"id": "C0271288", "name": "C0271288#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022578", "name": "C0022578#ent", "pos": [20, 21]}}
{"token": ["We", "studied", "immunoreactivity", "for", "calbindin-D", "28k", "CaBP", ")", ",", "an", "intracellular", "calcium-binding", "protein", "in", "the", "cerebellum", "of", "control", "subjects", "of", "patients", "with", "C0087012#ent", "<e1>", "SCD", ")", "including", "sporadic", "olivopontocerebellar", "atrophy", "C0740279#ent", "<e2>"], "h": {"id": "C0087012", "name": "C0087012#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0740279", "name": "C0740279#ent", "pos": [30, 31]}}
{"token": ["Moreover", ",", "in", "these", "conditions", ",", "C3272788#ent", "<e1>", "increased", "phosphatidylethanolamine", "levels", ",", "without", "variation", "of", "phosphatidylcholine", ",", "phosphatidylserine", ",", "and", "phosphatidylinositol", ",", "suggesting", "that", "C3272788#ent", "<e1>", "specifically", "increased", "the", "phosphatidylethanolamine", "biosynthesis", "C0011967#ent", "<e1>", "."], "h": {"id": "C3272788", "name": "C3272788#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [31, 32]}}
{"token": ["Other", "phosphate", "esters", "concentration", "changes", "at", "higher", "concentrations", "of", "C0036075#ent", "<e1>", "that", "reflected", "inadequate", "concentrations", "of", "C2744579#ent", "<e2>", "for", "glycolysis", "."], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "neither", "S1P", "nor", "PDGF", "modify", "intracellular", "calcium", "concentration", "[", "C0001477#ent", "<e1>", "(", "i", ")", ")", "and", "C1566790#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [18, 19]}}
{"token": ["This", "divergent", "trafficking", "of", "C1415586#ent", "<e1>", "implicates", "an", "alternative", "function", "C1415586#ent", "<e1>", ",", "independent", "of", "loading", "with", "C0030956#ent", "<e1>", "in", "the", "ER", "."], "h": {"id": "C1415586", "name": "C1415586#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}}
{"token": ["To", "examine", "temperament", ",", "stress", "response", "child", "psychological", "adjustment", "family", "environment", "pain", "sensitivity", "and", "stress", "response", "between", "children", "and", "adolescents", "with", "C0016053#ent", "<e1>", "JPFMS", ")", ",", "children", "with", "C0003864#ent", "<e2>", ",", "and", "healthy", "controls"], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [21, 22]}, "relation": "related_to", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [28, 29]}}
{"token": ["Differences", "between", "healthy", "women", "and", "women", "reporting", "pelvic", "joint", "syndrome", "C0016053#ent", "<e1>", ",", "whiplash", ",", "or", "C0003864#ent", "<e2>", "were", "significant", "in", "bleeding", "disorders", "chronic", "pelvic", "pain", "inflammatory", "pelvic", "disease"], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "we", "show", "that", "the", "C0003402#ent", "<e1>", "vitamin", "E", "2,2,5,7,8-pentamethyl-6-chromanol", "(", "PMCol", ")", ",", "has", "C0002842#ent", "<e2>", "prostate", "carcinoma", "cells", "."], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [18, 19]}}
{"token": ["In", "cells", "co-expressing", "dopamine", "transporter", "D3", "receptors", "the", "D2/D3", "agonist", "C0072892#ent", "<e1>", "produced", "a", "rapid", ",", "concentration-dependent", ",", "and", "C0043167#ent", "<e2>", "toxin-sensitive", "increase", "of", "ASP(+", ")", "uptake", "."], "h": {"id": "C0072892", "name": "C0072892#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "C0072892#ent", "<e1>", "were", "reversed", "by", "the", "D2", "antagonist", "spiperone", "and", "by", "C0043167#ent", "<e2>", "pretreatment", "."], "h": {"id": "C0072892", "name": "C0072892#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [14, 15]}}
{"token": ["Incubation", "of", "lung", "tissue", "in", "vitro", "DHEA", "demonstrated", "ablation", "of", "tissue", "C2939465#ent", "<e1>", "activity", "without", "decreasing", "C0007367#ent", "<e2>", ",", "glutathione", "peroxidase", "or", "superoxide", "dismutase", "activity"], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [16, 17]}}
{"token": ["TATA-binding", "protein", "factors", "(", "C2699751#ent", "<e1>", ")", "in", "TFIID", "are", "required", "for", "C0812312#ent", "<e2>", "stimulate", "transcription", ",", "but", "the", "mechanism", "by", "which", "C2699751#ent", "<e1>", "function", "is", "poorly", "understood", "."], "h": {"id": "C0812312", "name": "C0812312#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2699751", "name": "C2699751#ent", "pos": [4, 5]}}
{"token": ["This", "review", "is", "focused", "on", "the", "role", "of", "the", "mitochondrial", "respiratory", "chain", "both", "source", "and", "target", "of", "reactive", "oxygen", "nitrogen", "species", "as", "nitric", "oxide", "C0038838#ent", "<e1>", "and", "peroxynitrite", "produced", "in", "C0917798#ent", "<e2>"], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [30, 31]}}
{"token": ["Iron", "loaded", "persons", "are", "at", "increased", "risk", "for", "infection", ",", "neoplasia", ",", "C0003892#ent", "<e1>", ",", "cardiomyopathy", "and", "an", "array", "of", "endocrine", "and", "C0524851#ent", "<e2>"], "h": {"id": "C0003892", "name": "C0003892#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0524851", "name": "C0524851#ent", "pos": [22, 23]}}
{"token": ["C4082991#ent", "<e1>", "expression", "was", "strong", "in", "the", "C0719022#ent", "<e2>", "and", "bronchiolar", "epithelial", "cells", "mild", "to", "moderate", "in", "various", "renal", "microanatomic", "locations", ",", "and", "absent", "in", "cardiac", "tissues"], "h": {"id": "C4082991", "name": "C4082991#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [7, 8]}}
{"token": ["The", "C0034861#ent", "<e1>", "not", "catalyze", "bioactivation", "of", "C0047964#ent", "<e2>", ",", "a", "potent", "pulmonary", "carcinogen"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0047964", "name": "C0047964#ent", "pos": [7, 8]}}
{"token": ["A", "case", "report", "presented", "of", "a", "patient", "with", "pathologically", "confirmed", "C0795996#ent", "<e1>", "experienced", "episodic", "syncope", "as", "a", "result", "of", "C0025183#ent", "<e2>", "inhalation", "through", "her", "mouth", "and", "nose", "."], "h": {"id": "C0795996", "name": "C0795996#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025183", "name": "C0025183#ent", "pos": [19, 20]}}
{"token": ["Twelve", "patients", "with", "C0009324#ent", "<e1>", "treated", "for", "six", "months", "with", "each", "of", "C0012694#ent", "<e2>", "2", "g/day", ")", "and", "placebo", "in", "a", "double-blind", "cross-over", "trial", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [12, 13]}}
{"token": ["The", "ERK1/2", "activation", "is", "dependent", "on", "C1709402#ent", "<e1>", "because", "protein", "kinase", "B", "phosphorylated", "by", "C0235480#ent", "<e2>", "and", "inhibited", "by", "wortmannin", "and", "LY294002", ",", "but", "not", "by", "U0126", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [14, 15]}}
{"token": ["C0039902#ent", "<e1>", "(6-TG)-induced", "differentiation", "of", "hypoxanthine", "phosphoribosyltransferase", "IMP", ":", "C0002492#ent", "<e2>", "EC", "2.4.2.8)-deficient", "HL-60", "cells", "characterized", "by", "2", "days", "of", "growth", ",", "after", "which", "morphological", "differentiation", "proceeds", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0002492", "name": "C0002492#ent", "pos": [9, 10]}}
{"token": ["C1425186#ent", "<e1>", "has", "been", "demonstrated", "to", "be", "an", "C1417123#ent", "<e2>", "."], "h": {"id": "C1425186", "name": "C1425186#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [8, 9]}}
{"token": ["Human", "IgG", "and", "C1415975#ent", "<e1>", "antibody", "responses", "to", "clostridial", "collagenase", "C1417613#ent", "<e2>", ")", "were", "monitored", "in", "150", "untreated", "healthy", "blood", "donors", "and", "44", "patients", "receiving", "intrapenile", "injections", "collagenase", "for", "treatment", "of", "Peyronie's", "disease"], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417613", "name": "C1417613#ent", "pos": [10, 11]}}
{"token": ["Iron", "metabolism", "be", "altered", "in", "patients", "with", "C0520463#ent", "<e1>", "In", "an", "attempt", "to", "evaluate", "whether", "excess", "C1166521#ent", "<e2>", "contributes", "to", "liver", "injury", "we", "used", "phlebotomy", "for", "removal", "of", "C1166521#ent", "<e2>", "from", "patients", "with", "chronic", "hepatitis", "C."], "h": {"id": "C0520463", "name": "C0520463#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [16, 17]}}
{"token": ["We", "now", "demonstrate", "that", "treatment", "of", "MDCK", "cells", "antimycin", "A", "deoxyglucose", "activates", "C0010656#ent", "<e1>", "mediated", "pathways", "that", "cleave", "C0694872#ent", "<e2>", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [18, 19]}}
{"token": ["Peptide", "conformations", "analyzed", "by", "circular", "dichroism", "spectroscopy", "aqueous", "buffer", ",", "C0272170#ent", "<e1>", ",", "lysophosphatidylglycerol", "micelles", "and", "organic", "solvents", "methanol", ",", "trifluoroethanol", ",", "and", "C0022237#ent", "<e2>", ")", "."], "h": {"id": "C0272170", "name": "C0272170#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022237", "name": "C0022237#ent", "pos": [23, 24]}}
{"token": ["These", "results", "give", "evidence", "that", "the", "synthesis", "of", "the", "component", "C1305923#ent", "<e1>", "of", "the", "C0060094#ent", "<e2>", "induced", "during", "the", "development", "of", "bioluminescence", "and", "may", "be", "under", "the", "same", "control", "as", "luciferase", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0060094", "name": "C0060094#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "the", "bone", "marrow", "dysfunction", "C0268226#ent", "<e1>", "features", "of", "C0268255#ent", "<e2>", "have", "not", "been", "previously", "recognized", ",", "and", "should", "be", "added", "to", "the", "clinical", "phenotypic", "description", "."], "h": {"id": "C0268226", "name": "C0268226#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268255", "name": "C0268255#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C1096902#ent", "<e1>", "enters", "in", "the", "differential", "diagnosis", "C0020305#ent", "<e2>", "a", "storage", "disease", "phenotype", "."], "h": {"id": "C1096902", "name": "C1096902#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [9, 10]}}
{"token": ["Combined", "exposure", "of", "to", "C0011777#ent", "<e1>", "and", "RU", "38486", "completely", "restored", "baseline", "levels", "of", "C3273854#ent", "<e2>"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273854", "name": "C3273854#ent", "pos": [14, 15]}}
{"token": ["This", "report", "describes", "a", "patient", "with", "metastatic", "malignant", "melanoma", "treated", "with", "recombinant", "human", "interleukin", "4", "who", "developed", "C0042900#ent", "<e1>", "and", "severe", "C0339143#ent", "<e2>", "therapy", "."], "h": {"id": "C0042900", "name": "C0042900#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [21, 22]}}
{"token": ["Pulsed", "field", "gel", "electrophoresis", "analysis", "that", "both", "C1413927#ent", "<e1>", "and", "CL2", "are", "in", "the", "C0024518#ent", "<e2>", "are", "about", "16", "kilobases", "apart", "."], "h": {"id": "C1413927", "name": "C1413927#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [14, 15]}}
{"token": ["There", "were", "marked", "potentiating", "effects", "on", "delayed", "hypersensitivity", "reaction", "induced", "by", "2", ",", "4-dinitrochlorobenzene", "in", "normal", "NIH", "mice", "treated", "with", "C2350236#ent", "<e1>", "as", "well", "as", "in", "immunodepressed", "mice", "induced", "by", "C1161438#ent", "<e2>", "."], "h": {"id": "C2350236", "name": "C2350236#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [30, 31]}}
{"token": ["These", "results", "indicate", "at", "C0751039#ent", "<e1>", "significantly", "decreased", "body", "weight", "increased", "BT", "without", "decreasing", "mucosal", "structure", "C0271650#ent", "<e2>", "intestinal", "isografts.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0271650", "name": "C0271650#ent", "pos": [16, 17]}}
{"token": ["The", "glucose", "2-deoxyglucose", "C0017720#ent", "<e1>", "specificity", "of", "the", "C0014442#ent", "<e2>", "is", "similar", "to", "the", "substrate", "specificity", "for", "B.", "subtilis", "spore", "germination", ",", "suggesting", "that", "the", "spore", "glucose", "dehydrogenase", "play", "some", "role", "in", "spore", "germination"], "h": {"id": "C0017720", "name": "C0017720#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}}
{"token": ["C0017720#ent", "<e1>", "isoform", "2", "(", "NDST-2", ")", ",", "a", "key", "C0014442#ent", "<e2>", "in", "the", "biosynthesis", "of", "heparin", ",", "contains", "two", "distinct", "activities", "."], "h": {"id": "C0017720", "name": "C0017720#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["One", "of", "the", "enzymes", "responsible", "for", "the", "production", "of", "selectin", "ligands", "C1429589#ent", "<e1>", "FUT4", ")", ",", "a", "member", "of", "C0016790#ent", "<e2>"], "h": {"id": "C1429589", "name": "C1429589#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0016790", "name": "C0016790#ent", "pos": [19, 20]}}
{"token": ["It", "is", "also", "suggested", "that", "C0081876#ent", "<e1>", "does", "not", "influence", "the", "down-regulation", "of", "gastric", "prostaglandin", "production", "associated", "with", "C3536840#ent", "<e2>", "treatment", "."], "h": {"id": "C0081876", "name": "C0081876#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536840", "name": "C3536840#ent", "pos": [18, 19]}}
{"token": ["All", "of", "the", "disulfide", "bridges", "this", "polypeptide", ",", "like", "those", "of", "human", "and", "C1416161#ent", "<e1>", "can", "be", "cleaved", "by", "reducing", "C0991617#ent", "<e2>", "even", "in", "the", "absence", "of", "denaturing", "solvents", "."], "h": {"id": "C1416161", "name": "C1416161#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [20, 21]}}
{"token": ["In", "the", "present", "study", ",", "combined", "use", "of", "a", "farnesyl", "transferase", "inhibitor", "C0759338#ent", "<e1>", "(", "lonafarnib", ")", ",", "with", "the", "C0596112#ent", "<e2>", "imatinib", ",", "daunorubicin", ",", "cytosine", "arabinoside", "or", "etoposide", "was", "investigated", "by", "cell", "proliferation", "assays"], "h": {"id": "C0759338", "name": "C0759338#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0596112", "name": "C0596112#ent", "pos": [20, 21]}}
{"token": ["In", "the", "present", "study", ",", "combined", "use", "of", "a", "farnesyl", "transferase", "inhibitor", "SCH66336", "(", "C0759338#ent", "<e1>", ")", ",", "with", "the", "C0596112#ent", "<e2>", "imatinib", ",", "daunorubicin", ",", "cytosine", "arabinoside", "or", "etoposide", "was", "investigated", "by", "cell", "proliferation", "assays"], "h": {"id": "C0759338", "name": "C0759338#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0596112", "name": "C0596112#ent", "pos": [20, 21]}}
{"token": ["Agarose", "bead-coated", "phosphorylated", "ITIM", "peptides", "(", "pITIMs", ")", "bind", "in", "vitro", "C0088353#ent", "<e1>", "SHIP1", "and", "SHIP2", ")", "and", "the", "two-SH2", "protein", "tyrosine", "phosphatases", "SHP-1", "and", "C1566685#ent", "<e2>", ")", "."], "h": {"id": "C0088353", "name": "C0088353#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1566685", "name": "C1566685#ent", "pos": [25, 26]}}
{"token": ["Two", "tag", "single-nucleotide", "polymorphisms", "SNPs", ")", "of", "C1710516#ent", "<e1>", "and", "four", "tag", "SNPs", "of", "C1846414#ent", "<e2>", "were", "selected", "and", "genotyped", "in", "318", "MTLE", "patients", "and", "315", "non-epileptic", "individuals", "."], "h": {"id": "C1710516", "name": "C1710516#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1846414", "name": "C1846414#ent", "pos": [14, 15]}}
{"token": ["C0282138#ent", "<e1>", "inhibited", "the", "response", "to", "xanthine", "oxidase", "in", "contrast", ",", "C0733398#ent", "<e2>", "plus", "propranolol", "did", "not", "affect", "it", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0733398", "name": "C0733398#ent", "pos": [11, 12]}}
{"token": ["We", "report", "the", "case", "of", "a", "60-year-old", "woman", "with", "autosomal", "dominant", "C3149841#ent", "<e1>", "ADPKD", ")", "that", "presented", "with", "headache", "and", "C0029089#ent", "<e2>"], "h": {"id": "C3149841", "name": "C3149841#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029089", "name": "C0029089#ent", "pos": [20, 21]}}
{"token": ["A", "possible", "explanation", "may", "be", "differences", "in", "the", "levels", "of", "C3850168#ent", "<e1>", "such", "as", "C2757070#ent", "<e2>", "."], "h": {"id": "C3850168", "name": "C3850168#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [14, 15]}}
{"token": ["Fusion", "proteins", "a", "truncated", "mutant", "of", "C0027112#ent", "<e1>", "S1dC", ")", "and", "green", "fluorescent", "protein", "GFP", ")", "were", "expressed", "in", "vitro", "C0035681#ent", "<e2>", "rabbit", "reticulocyte", "lysate"], "h": {"id": "C0027112", "name": "C0027112#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [20, 21]}}
{"token": ["The", "dynamics", "of", "the", "immunological", "parameters", "was", "studied", "in", "17", "patients", "with", "C0026769#ent", "<e1>", "MS", ")", "who", "received", "C0032950#ent", "<e2>", "therapy", "in", "combination", "with", "plasmacytapheresis", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [18, 19]}}
{"token": ["These", "results", "demonstrate", "heterogeneity", "in", "the", "C0014442#ent", "<e1>", "in", "a", "deficiency", "of", "C1536500#ent", "<e2>", "fibroblasts", "from", "patients", "with", "3-ketothiolase", "deficiency"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1536500", "name": "C1536500#ent", "pos": [12, 13]}}
{"token": ["We", "suggest", "that", "the", "C0014442#ent", "<e1>", "defective", "in", "the", "patients", "was", "the", "C1536500#ent", "<e2>", "in", "ketone", "body", "in", "extrahepatic", "tissues"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1536500", "name": "C1536500#ent", "pos": [12, 13]}}
{"token": ["This", "negative", "effect", "although", "not", "preventing", "dual", "binding", "C0030346#ent", "<e1>", "and", "CPA", ",", "was", "correlated", "with", "an", "increased", "binding", "affinity", "for", "C0030346#ent", "<e1>", "presumably", "due", "to", "non-specific", "interactions", "with", "the", "C1705930#ent", "<e1>"], "h": {"id": "C0030346", "name": "C0030346#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705930", "name": "C1705930#ent", "pos": [30, 31]}}
{"token": ["Based", "on", "the", "above", "studies", ",", "T-0509", "appears", "to", "be", "a", "highly", "selective", "betaI-adrenoceptor", "agonist", "full", "agonist", "properties", ",", "while", "denopamine", "and", "C0078595#ent", "<e1>", "appear", "to", "be", "selective", ",", "but", "partial", "C0001644#ent", "<e2>"], "h": {"id": "C0078595", "name": "C0078595#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [31, 32]}}
{"token": ["In", "humans", ",", "mutations", "of", "the", "C0010803#ent", "<e1>", "gene", "are", "associated", "with", "cornea", "plana", "C1704801#ent", "<e2>", ")", "that", "manifests", "decreases", "in", "vision", "acuity", "to", "the", "flattened", "forward", "convex", "curvature", "of", "cornea", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704801", "name": "C1704801#ent", "pos": [14, 15]}}
{"token": ["It", "was", "proven", "by", "mass", "spectrometric", "using", "an", "ion-trap", "and", "time-of-flight", "instrument", "a", "covalent", "bond", "form", "between", "C0060276#ent", "<e1>", "and", "the", "sulfhydryl", "group", "cysteine", "or", "cysteinyl", "residues", "in", "C0030956#ent", "<e2>", "."], "h": {"id": "C0060276", "name": "C0060276#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [28, 29]}}
{"token": ["In", "animals", ",", "2", "x", "0.5", "mg", "of", "tyrphostin", "A47", "injected", "intraperitoneally", ")", "caused", "a", "significant", "reduction", "of", "parasite", "growth", "compared", "with", "the", "vehicle", "C0012403#ent", "<e1>", "the", "inactive", "C1142927#ent", "<e2>"], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1142927", "name": "C1142927#ent", "pos": [28, 29]}}
{"token": ["In", "this", "latter", "hypothesis", ",", "the", "progression", "of", "C0004153#ent", "<e1>", "can", "be", "explained", "in", "terms", "of", "the", "immune", "response", "bacterial", "heat", "shock", "proteins", "C3813609#ent", "<e2>", ")", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3813609", "name": "C3813609#ent", "pos": [23, 24]}}
{"token": ["Rubber", "elongation", "factor", "hevein", "preprotein", ",", "C0082876#ent", "<e1>", ",", "patatin", ",", "and", "C0007641#ent", "<e2>", "have", "been", "identified", "as", "allergic", "proteins"], "h": {"id": "C0082876", "name": "C0082876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007641", "name": "C0007641#ent", "pos": [12, 13]}}
{"token": ["The", "C0082876#ent", "<e1>", "components", "and", "C0007641#ent", "<e2>", "were", "isolated", "and", "several", "enzymic", "and", "structural", "properties", "investigated", "."], "h": {"id": "C0082876", "name": "C0082876#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007641", "name": "C0007641#ent", "pos": [5, 6]}}
{"token": ["Trace", "metals", "not", "significantly", "influence", "the", "amount", "of", "C0597979#ent", "<e1>", "produced", "relative", "to", "C0117059#ent", "<e2>", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0117059", "name": "C0117059#ent", "pos": [13, 14]}}
{"token": ["C1522575#ent", "<e1>", "expression", "in", "endometriosis", ",", "an", "angiogenesis-dependent", ",", "C1857728#ent", "<e2>", "similar", "to", "that", "seen", "in", "eutopic", "endometrium"], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1857728", "name": "C1857728#ent", "pos": [9, 10]}}
{"token": ["During", "the", "first", "3", "yr", "of", "life", "54", "(", "34", "%", ")", "of", "the", "158", "patients", "presenting", "with", "C0003615#ent", "<e1>", "had", "an", "C0341353#ent", "<e2>", "the", "time", "the", "diagnosis", "was", "made", "."], "h": {"id": "C0003615", "name": "C0003615#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0341353", "name": "C0341353#ent", "pos": [22, 23]}}
{"token": ["As", "such", ",", "they", "also", "play", "a", "pivotal", "role", "in", "the", "genesis", "of", "diseases", "including", "cancer", ",", "C0011849#ent", "<e1>", ",", "aging", ",", "and", "C1285162#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [23, 24]}}
{"token": ["Within", "the", "last", "century", "the", "prevalence", "and", "mortality", "rates", "C0011849#ent", "<e1>", "and", "other", "C1285162#ent", "<e2>", "increased", "considerably", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [13, 14]}}
{"token": ["Ten", "male", "patients", "suffering", "from", "stable", "angina", "pectoris", "studied", "at", "rest", "and", "immediately", "after", "exercise", "during", "treatment", "either", "with", "timolol", "(", "a", "C0304516#ent", "<e1>", "or", "with", "C0025859#ent", "<e2>", "(", "a", "beta", "1-selective", "blocker", "."], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [26, 27]}}
{"token": ["When", "red", "cells", "pretreated", "by", "C0304516#ent", "<e1>", "or", "noncardioselective", "beta-blocking", "drugs", "e.g.", ",", "C0025859#ent", "<e2>", "and", "propranolol", ")", ",", "significantly", "fewer", "erythrocytes", "remained", "adherent", "to", "the", "endothelial", "monolayers", "after", "repeated", "washing", "."], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [13, 14]}}
{"token": ["Transcriptional", "repression", "SMC1beta", "and", "STAG3", "by", "C3540497#ent", "<e1>", "involves", "multiple", "mechanisms", ",", "including", "methylation", "of", "C3829685#ent", "<e2>", "lysine", "9", "lysine", "27"], "h": {"id": "C3540497", "name": "C3540497#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3829685", "name": "C3829685#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "describe", "a", "mouse", "Fc", "receptor", "designated", "Fc", "alpha/microR", ",", "and", "its", "human", "C1334043#ent", "<e1>", ",", "that", "bind", "both", "C1706005#ent", "<e2>", "and", "IgA", "with", "intermediate", "or", "high", "affinity", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "case", "of", "a", "30-year-old", "man", "presenting", "with", "abdominal", "pain", "fever", ",", "C0948268#ent", "<e1>", "hepatosplenomegaly", ",", "acute", "renal", "failure", "cervical", "lymph", "nodes", "anaemia", "and", "C0040034#ent", "<e2>", "."], "h": {"id": "C0948268", "name": "C0948268#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [26, 27]}}
{"token": ["Basal", "cell", "cytoskeletons", ",", "prepared", "by", "sequential", "treatment", "with", "Triton", "X-100", "C0057457#ent", "<e1>", ",", "and", "2", "M", "C1412125#ent", "<e2>", "continue", "to", "react", "with", "BP", "antibodies"], "h": {"id": "C0057457", "name": "C0057457#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [17, 18]}}
{"token": ["However", ",", "additional", "labeled", "tryptic", "peptides", "are", "seen", "when", "C2987364#ent", "<e1>", "EF-2", "is", "ADP-ribosylated", "by", "C0058400#ent", "<e2>"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0058400", "name": "C0058400#ent", "pos": [15, 16]}}
{"token": ["Although", "significantly", "different", "in", "sequence", "from", "its", "Xenopus", "counterpart", ",", "C2674616#ent", "<e1>", "shared", "with", "xFAST-1", "the", "ability", "to", "bind", "to", "human", "C1566790#ent", "<e2>", "and", "activate", "an", "activin", "response", "element", "ARE", ")", "."], "h": {"id": "C2674616", "name": "C2674616#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [21, 22]}}
{"token": ["C0042769#ent", "<e1>", "by", "herpes", "simplex", "virus", "2", "papillomavirus", "(", "wart", ")", "are", "C0277550#ent", "<e2>", "the", "United", "States"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0277550", "name": "C0277550#ent", "pos": [12, 13]}}
{"token": ["Metabolic", "alkalosis", "a", "high", "urine", "K/C", "ratio", "and", "hypertension", "suggests", "C1384514#ent", "<e1>", "Cushing", "syndrome", "congenital", "adrenal", "hyperplasia", "renal", "artery", "stenosis", "apparent", "mineralocorticoid", "excess", ",", "or", "C3854315#ent", "<e2>"], "h": {"id": "C1384514", "name": "C1384514#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3854315", "name": "C3854315#ent", "pos": [25, 26]}}
{"token": ["All", "3", "C0991617#ent", "<e1>", "have", "a", "low", "risk", "phototoxicity", ",", "but", "C1321744#ent", "<e2>", "is", "associated", "with", "increased", "risk", "of", "skin", "rash", "is", "not", "a", "photoreaction", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1321744", "name": "C1321744#ent", "pos": [11, 12]}}
{"token": ["C0991617#ent", "<e1>", "such", "as", "moxifloxacin", "and", "C1321744#ent", "<e2>", "with", "high", "ratios", "this", "organism", "are", "preferred", ",", "and", "agents", "such", "as", "ciprofloxacin", "with", "low", "ratios", "be", "avoided", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1321744", "name": "C1321744#ent", "pos": [6, 7]}}
{"token": ["This", "was", "due", "to", "reciprocal", "modulation", "by", "C3542429#ent", "<e1>", "and", "NRB", "of", "the", "potency", "of", "RGS2", "to", "inhibit", "C0001477#ent", "<e2>", "by", "alphaAR", "."], "h": {"id": "C3542429", "name": "C3542429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [18, 19]}}
{"token": ["Coexpression", "of", "C3542429#ent", "<e1>", "or", "NRB", "with", "the", "alpha(1B)AR", "in", "Xenopus", "oocytes", "that", "C3542429#ent", "<e1>", "reduces", ",", "whereas", "NRB", "increases", ",", "the", "intensity", "of", "C0001477#ent", "<e1>", "signaling", "by", "alpha(1B)AR", "."], "h": {"id": "C3542429", "name": "C3542429#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [24, 25]}}
{"token": ["Sp1", "is", "a", "ubiquitous", "C1417703#ent", "<e1>", "plays", "a", "key", "role", "in", "maintaining", "C1332461#ent", "<e2>", "'", "house-keeping'", "genes"], "h": {"id": "C1417703", "name": "C1417703#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332461", "name": "C1332461#ent", "pos": [12, 13]}}
{"token": ["The", "fact", "that", "both", "the", "activation", "of", "C1434268#ent", "<e1>", "the", "phosphorylation", "of", "C0086376#ent", "<e2>", "are", "desensitized", "in", "PAF-pretreated", "platelets", "suggests", "that", "a", "close", "\"", "regulatory", "\"", "intercommunication", "between", "these", "processes", "exists", "."], "h": {"id": "C1434268", "name": "C1434268#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["C0796274#ent", "<e1>", "diagnosed", "with", "this", "symptom", "complex", "of", "C0018784#ent", "<e2>", "pontobulbar", "palsy"], "h": {"id": "C0796274", "name": "C0796274#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [8, 9]}}
{"token": ["Thus", "despite", "a", "dilator", "activity", "C1335796#ent", "<e1>", "nor", "ADM", "appears", "to", "mediate", "C0020429#ent", "<e2>", "activity", "in", "the", "periphery", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [12, 13]}}
{"token": ["We", "have", "compared", "the", "ability", "of", "C1335796#ent", "<e1>", "and", "ADM", "to", "modulate", "microvascular", "and", "thermal", "C0020429#ent", "<e2>", "responses", "in", "rat", "skin", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [15, 16]}}
{"token": ["role", "for", "C1705447#ent", "<e1>", "the", "daily", "regulation", "of", "activity", ",", "the", "actions", "of", "these", "peptides", "might", "also", "contribute", "to", "the", "behavioral", "etiology", "of", "C0029896#ent", "<e2>", "in", "which", "C1705447#ent", "<e1>", "expressed", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1705447", "name": "C1705447#ent", "pos": [2, 3]}}
{"token": ["C0024530#ent", "<e1>", "breakthrough", "despite", "C0008241#ent", "<e2>", "prophylaxis", "was", "always", "associated", "with", "mutations", "in", "the", "dhfr", "gene", "always", "the", "Asn-108", "mutation", "and", "often", "the", "Ile-51", "and", "Arg-59", "mutations", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0008241", "name": "C0008241#ent", "pos": [4, 5]}}
{"token": ["Phase", "II", "1993", ")", "included", "126", "participants", ",", "who", "were", "offered", "C0024530#ent", "<e1>", "prophylaxis", "with", "C0008241#ent", "<e2>", "(", "200", "mg/day", ")", "and", "chloroquine", "(", "300", "mg/week", ")", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [11, 12]}, "relation": "may_be_prevented_by", "t": {"id": "C0008241", "name": "C0008241#ent", "pos": [15, 16]}}
{"token": ["Activation", "of", "AMPK", "or", "overexpression", "of", "C0669365#ent", "<e1>", "active", "AMPK", "was", "sufficient", "to", "activate", "C1418928#ent", "<e2>", "and", "promote", "Na", ",", "K-ATPase", "endocytosis", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418928", "name": "C1418928#ent", "pos": [14, 15]}}
{"token": ["Most", "overexpressed", "C1418928#ent", "<e1>", "(", "92", "%", ")", "resided", "in", "membrane", "and", "cytoskeletal", "fractions", "indicating", "C0669365#ent", "<e2>", "activation", "of", "C1418928#ent", "<e1>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418928", "name": "C1418928#ent", "pos": [2, 3]}}
{"token": ["Three", "children", "presented", "with", "C0024031#ent", "<e1>", "to", "the", "leg", "and", "with", "C0026821#ent", "<e2>", "of", "the", "hamstring", "and", "paravertebral", "muscles"], "h": {"id": "C0024031", "name": "C0024031#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026821", "name": "C0026821#ent", "pos": [11, 12]}}
{"token": ["NGF", "did", "not", "modulate", "the", "total", "amount", "of", "ERK", "proteins", "coimmunoprecipitated", "with", "C1363982#ent", "<e1>", "but", "did", "markedly", "stimulate", "the", "level", "of", "p75-associated", "C0752312#ent", "<e2>", "catalytic", "activity"], "h": {"id": "C1363982", "name": "C1363982#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [22, 23]}}
{"token": ["Expression", "profile", "analysis", "that", "the", "expression", "of", "membrane-associated", "transporter", "protein", "C4084746#ent", "<e1>", ")", "varied", "similarly", "to", "the", "C1413933#ent", "<e2>", "DCT", ")", "and", "tyrosinase", "related", "protein", "1", "(", "TYRP1", ")", "(", "Proc", "."], "h": {"id": "C4084746", "name": "C4084746#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413933", "name": "C1413933#ent", "pos": [17, 18]}}
{"token": ["Expression", "profile", "analysis", "that", "the", "expression", "of", "membrane-associated", "transporter", "protein", "C4084746#ent", "<e1>", ")", "varied", "similarly", "to", "the", "melanogenic", "enzymes", "dopachrome", "tautomerase", "C1413933#ent", "<e2>", ")", "and", "tyrosinase", "related", "protein", "1", "(", "TYRP1", ")", "(", "Proc", "."], "h": {"id": "C4084746", "name": "C4084746#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413933", "name": "C1413933#ent", "pos": [21, 22]}}
{"token": ["There", "were", "80", "patients", "with", "measurable", "metastatic", "or", "unresectable", "pancreatic", "cancer", "assigned", "to", "treatment", "with", "either", "DHAD", ",", "C0733688#ent", "<e1>", ",", "aclacinomycin", ",", "or", "C0075018#ent", "<e2>", "."], "h": {"id": "C0733688", "name": "C0733688#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0075018", "name": "C0075018#ent", "pos": [24, 25]}}
{"token": ["In", "human", ",", "CYP2E1", ",", "C0207509#ent", "<e1>", "and", "CYP3A4", "show", "substantial", "activity", ",", "and", "C1413868#ent", "<e2>", "also", "measurably", "metabolizes", "BDCM", "."], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413868", "name": "C1413868#ent", "pos": [14, 15]}}
{"token": ["Ethoxyresorufin", "O-deethylation", "C0207509#ent", "<e1>", ",", "coumarin", "7-hydroxylation", "by", "C1413868#ent", "<e2>", ",", "and", "chlorzoxazone", "6-hydroxylation", "CYP2E1", "were", "not", "inhibited", "by", "almost", "any", "of", "the", "methylenedioxyphenyl", "compounds", "."], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413868", "name": "C1413868#ent", "pos": [8, 9]}}
{"token": ["In", "severe", "cases", ",", "cTnI", "was", "positively", "correlated", "with", "C1705592#ent", "<e1>", "while", "negatively", "correlated", "with", "%", "C1705295#ent", "<e2>", "and", "LVEF", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705295", "name": "C1705295#ent", "pos": [16, 17]}}
{"token": ["The", "possible", "C1121259#ent", "<e1>", "of", "using", "live-attenuated", "strains", "for", "C0276240#ent", "<e2>", "production", "are", "discussed", "in", "the", "context", "of", "the", "global", "polio", "eradication", "initiative", "."], "h": {"id": "C1121259", "name": "C1121259#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0276240", "name": "C0276240#ent", "pos": [9, 10]}}
{"token": ["Results", "suggest", "that", "transient", "as", "well", "as", "persistent", "C0018784#ent", "<e1>", "may", "be", "associated", "with", "C3899125#ent", "<e2>", "KD", ",", "and", "may", "be", "associated", "with", "laboratory", "markers", "more", "severe", "systemic", "inflammation"], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3899125", "name": "C3899125#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "varying", "stimulus", "durations", ",", "intensities", "and", "frequencies", "are", "sometimes", "needed", "to", "decide", "whether", "or", "not", "C0599295#ent", "<e1>", "c-waves", "can", "be", "elicited", "in", "different", "C0012634#ent", "<e2>", "or", "suspected", "disorders"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [25, 26]}}
{"token": ["A", "medium", "frequency", "flicker", "stimulus", "of", "10", "Hz", "is", "evaluated", "in", "routine", "clinical", "C0599295#ent", "<e1>", "recording", "in", "detecting", "C0012634#ent", "<e2>"], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["Poly(dimethylsiloxane", ")", "microchip", "capillary", "electrophoresis", "with", "amperometric", "detection", "has", "been", "used", "for", "rapid", "separation", "and", "determination", "of", "C2917659#ent", "<e1>", "and", "its", "hydrolysate", ",", "i.e.", "C0000970#ent", "<e2>", "."], "h": {"id": "C2917659", "name": "C2917659#ent", "pos": [17, 18]}, "relation": "has_chemical_structure", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [24, 25]}}
{"token": ["Co-oxidation", "of", "phenacetin", ",", "C2917659#ent", "<e1>", "(", "APAP", ")", "and", "C0000970#ent", "<e2>", "(", "p-AP", ")", "by", "prostaglandin", "H", "synthase", "PHS", ")", "was", "investigated", "in", "human", "and", "rat", "renal", "microsomes"], "h": {"id": "C2917659", "name": "C2917659#ent", "pos": [4, 5]}, "relation": "has_chemical_structure", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [10, 11]}}
{"token": ["Three", "of", "the", "patients", ",", "one", "with", "C0265344#ent", "<e1>", "and", "two", "with", "C1568247#ent", "<e2>", "have", "decreases", "in", "insulin-receptor", "mRNA", "but", "on", "genomic", "blot", "analysis", "no", "obvious", "abnormalities", "in", "the", "insulin-receptor", "gene"], "h": {"id": "C0265344", "name": "C0265344#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1568247", "name": "C1568247#ent", "pos": [12, 13]}}
{"token": ["Parents", "of", "neither", "patient", "had", "clinical", "manifestations", "C0265344#ent", "<e1>", "or", "the", "C1568247#ent", "<e2>"], "h": {"id": "C0265344", "name": "C0265344#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1568247", "name": "C1568247#ent", "pos": [11, 12]}}
{"token": ["Four", "patients", "developed", "transient", "ST", "segment", "changes", "in", "the", "C0030196#ent", "<e1>", "leads", "of", "the", "ECG", "and", "five", "patients", "had", "C0340288#ent", "<e2>"], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0340288", "name": "C0340288#ent", "pos": [19, 20]}}
{"token": ["C1419950#ent", "<e1>", "stimulation", "induced", "tyrosine", "dephosphorylation", "CD72", "and", "dissociation", "of", "C1335283#ent", "<e2>", "from", "CD72", "."], "h": {"id": "C1419950", "name": "C1419950#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335283", "name": "C1335283#ent", "pos": [10, 11]}}
{"token": ["Several", "investigators", "have", "demonstrated", "that", "C1518041#ent", "<e1>", "LHRHa", ")", "inhibit", "ovarian", "follicular", "depletion", "induced", "by", "C0729502#ent", "<e2>", "rodents", "."], "h": {"id": "C1518041", "name": "C1518041#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [15, 16]}}
{"token": ["However", ",", "it", "is", "not", "clear", "whether", "the", "circulating", "levels", "of", "C1705592#ent", "<e1>", "and", "VEGF", "correlate", "with", "the", "extents", "of", "C0007282#ent", "<e2>"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007282", "name": "C0007282#ent", "pos": [20, 21]}}
{"token": ["More", "recent", "studies", "indicate", "that", "Tokyo-Yokohama", "asthma", "is", "not", "a", "disease", "but", "a", "C0039082#ent", "<e1>", "seen", "in", "people", "with", "C0006277#ent", "<e2>", "asthma", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006277", "name": "C0006277#ent", "pos": [19, 20]}}
{"token": ["By", "microsequencing", ",", "C1538717#ent", "<e1>", "identified", "with", "a", "known", "protein", ",", "CArG", "box", "motif-binding", "factor", "A", "C3540480#ent", "<e2>", ")", ",", "which", "has", "been", "characterized", "as", "a", "transcriptional", "repressor", "and", "C2", "as", "its", "isoform", "protein"], "h": {"id": "C1538717", "name": "C1538717#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540480", "name": "C3540480#ent", "pos": [16, 17]}}
{"token": ["The", "adverse", "events", "with", "once", "daily", "administration", "of", "C0378482#ent", "<e1>", "20", "mg", "include", "C0231218#ent", "<e2>", ",", "nausea", ",", "diarrhoea", ",", "headache", ",", "dizziness", "and", "skin", "eruptions", "0.7", "to", "2.2", "%", "of", "patients", "."], "h": {"id": "C0378482", "name": "C0378482#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [13, 14]}}
{"token": ["C0020538#ent", "<e1>", "more", "frequent", "in", "C0028840#ent", "<e2>", "Odds", "Ratio", "2.36", ")", ";", "high", "diastolic", "pressure", "associated", "with", "and", "ocular", "hypertension", "OR", "=", "2.13", "and", "2.21", ",", "respectively", ")", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028840", "name": "C0028840#ent", "pos": [5, 6]}}
{"token": ["This", "study", "sought", "to", "compare", "the", "antihypertensive", "efficacy", "tolerability", "of", "a", "fixed-dose", "combination", "with", "C0717411#ent", "<e1>", "with", "that", "of", "C0051696#ent", "<e2>", "monotherapy", "in", "Chinese", "hypertensive", "subjects", "."], "h": {"id": "C0717411", "name": "C0717411#ent", "pos": [14, 15]}, "relation": "has_constitutional_part", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [19, 20]}}
{"token": ["C0059438#ent", "<e1>", "markedly", "suppressed", "IL-1beta-induced", "MUC5AC", "gene", "expression", "and", "C2983560#ent", "<e2>", "secretion", "via", "suppression", "of", "the", "phosphorylation", "of", "ERK", "MAP", "kinase", "MSK1", ",", "and", "transcription", "factor", "cAMP", "response", "element-binding", "protein"], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2983560", "name": "C2983560#ent", "pos": [9, 10]}}
{"token": ["Ten", "mg", "dexrabeprazole", "daily", "has", "been", "shown", "to", "be", "more", "effective", "than", "20", "mg", "C0378482#ent", "<e1>", "daily", "against", "gastroesophageal", "reflux", "disease", "C0017168#ent", "<e2>", ")", "."], "h": {"id": "C0378482", "name": "C0378482#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [21, 22]}}
{"token": ["Stimulation", "of", "the", "SR", "C1567357#ent", "<e1>", "by", "the", "catalytic", "subunit", "adenosine", "3',5'-cyclic", "C0010536#ent", "<e2>", "in", "a", "2.6-fold", "increase", "for", "Sham", "but", "only", "a", "1.6-fold", "increase", "for", "Hyp", "."], "h": {"id": "C1567357", "name": "C1567357#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [12, 13]}}
{"token": ["Although", "phorbol", "esters", "activate", "MAP", "kinase", "mimic", "the", "effects", "of", "insulin", "on", "PEPCK", "C0812327#ent", "<e1>", "inhibition", "of", "C0752313#ent", "<e2>", "has", "no", "effect", "phorbol", "ester", "inhibition", "of", "PEPCK", "C0812327#ent", "<e1>"], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [13, 14]}}
{"token": ["alpha3GT", "is", "a", "member", "of", "a", "family", "of", "metal-dependent", "retaining", "C1333828#ent", "<e1>", "including", "the", "histo-blood", "group", "A", "C0132555#ent", "<e2>"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "dissect", "the", "relationship", "of", "two", "C1422073#ent", "<e1>", "polyubiquitin-binding", "proteins", "C4049859#ent", "<e2>", "and", "Dsk2", ",", "and", "demonstrate", "how", "C4049859#ent", "<e2>", "filters", "Dsk2", "interactions", ",", "maintaining", "proper", "function", "of", "the", "ubiquitin-proteasome", "system", "."], "h": {"id": "C1422073", "name": "C1422073#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [11, 12]}}
{"token": ["The", "JNK", "inhibitor", "C0968383#ent", "<e1>", "inhibited", "the", "increase", "in", "C1336644#ent", "<e2>", "attenuated", "apoptosis", "induced", "by", "treatment", "with", "As(2)O(3", ")", "plus", "BSO", "."], "h": {"id": "C0968383", "name": "C0968383#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336644", "name": "C1336644#ent", "pos": [9, 10]}}
{"token": ["C0026896#ent", "<e1>", "a", "neuromuscular", "junction", "autoimmune", "disease", "may", "be", "associated", "to", "glandular", "autoimmune", "diseases", "as", "C0271737#ent", "<e2>", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271737", "name": "C0271737#ent", "pos": [15, 16]}}
{"token": ["Evidence", "suggests", "that", "C1335221#ent", "<e1>", "functions", "as", "a", "C0079427#ent", "<e2>", "because", "mice", "lacking", "C1335221#ent", "<e1>", "expression", "demonstrate", "increased", "colonic", "polyposis"], "h": {"id": "C1335221", "name": "C1335221#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [8, 9]}}
{"token": ["The", "authors", "indicate", "that", "besides", "the", "C1417487#ent", "<e1>", "and", "PINGYANGMYCIN", ",", "CDDP", "is", "another", "effective", "and", "useful", "C1254351#ent", "<e2>", "for", "squamous", "cell", "carcinoma"], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [17, 18]}}
{"token": ["C3815884#ent", "<e1>", "myhca", ")", "is", "the", "major", "C1413096#ent", "<e2>", "associated", "with", "myocarditis", "both", "in", "humans", "and", "in", "experimental", "autoimmune", "myocarditis", "EAM", ")", "in", "mice", "."], "h": {"id": "C3815884", "name": "C3815884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [7, 8]}}
{"token": ["C0262988#ent", "<e1>", "managed", "primarily", "with", "C0009262#ent", "<e2>", ",", "dapsone", "and", "prednisone", ",", "with", "recent", "studies", "indicating", "that", "there", "may", "be", "a", "synergistic", "effect", "pentoxifylline", "with", "dapsone", "."], "h": {"id": "C0262988", "name": "C0262988#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [5, 6]}}
{"token": ["The", "C1539479#ent", "<e1>", "of", "microtubules", "and", "of", "vimentin", "or", "keratin", "containing", "C1334214#ent", "<e2>", "infection", "with", "fusion", "or", "rounding", "producing", "strains", "of", "herpes", "simplex", "virus", "HSV", ")", "was", "investigated", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334214", "name": "C1334214#ent", "pos": [11, 12]}}
{"token": ["G", "protein-coupled", "receptors", "GPCRs", ")", "at", "the", "cell", "surface", "activate", "C0752348#ent", "<e1>", "inducing", "the", "C2362546#ent", "<e2>", "Galpha", ")", "subunit", "to", "exchange", "guanosine", "diphosphate", "guanosine", "triphosphate"], "h": {"id": "C0752348", "name": "C0752348#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2362546", "name": "C2362546#ent", "pos": [14, 15]}}
{"token": ["The", "authors", "report", "two", "cases", "of", "C0343208#ent", "<e1>", "EMC", ")", "manifested", "by", "purpura", ",", "fatigue", "and", "C0019559#ent", "<e2>", "."], "h": {"id": "C0343208", "name": "C0343208#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019559", "name": "C0019559#ent", "pos": [16, 17]}}
{"token": ["A", "total", "of", "1,328", "patients", "with", "C0949690#ent", "<e1>", "or", "rheumatoid", "arthritis", "entered", "into", "this", "double-blind", ",", "parallel", "group", "study", "C0076096#ent", "<e2>", "and", "piroxicam", "."], "h": {"id": "C0949690", "name": "C0949690#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0076096", "name": "C0076096#ent", "pos": [19, 20]}}
{"token": ["We", "suggest", ",", "therefore", ",", "that", "screening", "programs", "heterozygous", "beta-thalassemia", "in", "populations", "where", "C0002312#ent", "<e1>", "is", "also", "prevalent", ",", "should", "incorporate", "the", "determination", "of", "C1415478#ent", "<e2>", "in", "the", "first", "set", "of", "tests", "."], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [13, 14]}, "relation": "disease_has_associated_gene", "t": {"id": "C1415478", "name": "C1415478#ent", "pos": [24, 25]}}
{"token": ["Eastern", "patients", "had", "more", "C0002312#ent", "<e1>", "higher", "total", "haemoglobin", "fetal", "haemoglobin", "levels", ",", "and", "lower", "C1415478#ent", "<e2>", ",", "mean", "cell", "volume", "reticulocytes", ",", "and", "platelet", "counts"], "h": {"id": "C0002312", "name": "C0002312#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1415478", "name": "C1415478#ent", "pos": [15, 16]}}
{"token": ["By", "regular", "analysis", "factor", "H", "patients", "with", "C3273279#ent", "<e1>", ",", "the", "authors", "found", "a", "C0001733#ent", "<e2>", "an", "infant", "in", "whom", "C3273279#ent", "<e1>", "developed", "at", "8", "months", "of", "age", "."], "h": {"id": "C3273279", "name": "C3273279#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001733", "name": "C0001733#ent", "pos": [14, 15]}}
{"token": ["Ion", "filtration", "chromatography", "diethylaminoethyl-Sephadex", "A-25", "has", "been", "used", "to", "separate", "two", "C0026794#ent", "<e1>", "each", "of", "triose", "phosphate", "isomerase", "glyceraldehyde", "3-phosphate", "dehydrogenase", "glycerate", "3-phosphate", "kinase", "C1414402#ent", "<e2>", ",", "and", "phosphoglycerate", "mutase", "homogenates", "of", "developing", "castor", "oil", "(", "Ricinus", "communis", "L.", "cv", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414402", "name": "C1414402#ent", "pos": [24, 25]}}
{"token": ["The", "three", "sites", "on", "phage", "lambda", "DNA", "different", "from", "those", "cleaved", "by", "C0043116#ent", "<e1>", "Xma", "I", "and", "C1704669#ent", "<e2>"], "h": {"id": "C0043116", "name": "C0043116#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704669", "name": "C1704669#ent", "pos": [17, 18]}}
{"token": ["Based", "on", "the", "current", "knowledge", ",", "head", "louse", "Pediculus", "capitis", "and", "C0030758#ent", "<e1>", "Pediculus", "humanus", "are", "two", "different", "species", "that", "C0030499#ent", "<e2>", "specific", "parts", "of", "the", "human", "body", "and", "do", "not", "interbreed", "in", "vivo"], "h": {"id": "C0030758", "name": "C0030758#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [20, 21]}}
{"token": ["Under", "regulation", "by", "intracellular", "signaling", "system", "C1744635#ent", "<e1>", "arachidonic", "acid", "can", "be", "metabolized", "by", "downstream", "enzymes", "to", "generate", "C0356622#ent", "<e2>", "(", "PGs", ")", "and", "leukotrienes", "(", "LTs", ")", "."], "h": {"id": "C1744635", "name": "C1744635#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [18, 19]}}
{"token": ["These", "results", "indicate", "that", "C1335223#ent", "<e1>", "served", "as", "a", "C1425716#ent", "<e2>", "p53", "."], "h": {"id": "C1335223", "name": "C1335223#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425716", "name": "C1425716#ent", "pos": [9, 10]}}
{"token": ["Specific", "questioning", "about", "transient", "anisocoria", "and", "C0033377#ent", "<e1>", "should", "be", "considered", "when", "a", "C0751815#ent", "<e2>", "suspected", "."], "h": {"id": "C0033377", "name": "C0033377#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751815", "name": "C0751815#ent", "pos": [13, 14]}}
{"token": ["The", "C0037506#ent", "<e1>", "subscale", "of", "the", "EOQ", "can", "differentiate", "clinical", "from", "non-clinical", "groups", "C0003620#ent", "<e2>", "patients", "from", "healthy", "individuals", "with", "body", "mass", "index", "the", "C0003620#ent", "<e2>", "range", "."], "h": {"id": "C0037506", "name": "C0037506#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [13, 14]}}
{"token": ["Two", "patients", "on", "C0127615#ent", "<e1>", "and", "three", "on", "C1422585#ent", "<e2>", "had", "a", "marked", "deterioration", "during", "treatment", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422585", "name": "C1422585#ent", "pos": [8, 9]}}
{"token": ["Although", "both", "Btk", "and", "C1709409#ent", "<e1>", "were", "required", "for", "proliferation", "of", "splenic", "B", "cells", "response", "to", "C0812385#ent", "<e2>", "cross-linking", ",", "they", "contributed", "differently", "to", "anti-IgM-induced", "phosphorylation", "of", "ERK", "."], "h": {"id": "C1709409", "name": "C1709409#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [16, 17]}}
{"token": ["The", "substances", "tested", "(", "amphetamine", ",", "scopolamine", ",", "C0141756#ent", "<e1>", ",", "physostigmine", ",", "diazepam", "and", "beta-carboline", "benzodiazepine", "receptor", "antagonist", "C0078827#ent", "<e2>", ",", "all", "produced", "differing", "profiles", "of", "action", "on", "the", "performance", "parameters", "recorded", "."], "h": {"id": "C0141756", "name": "C0141756#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078827", "name": "C0078827#ent", "pos": [19, 20]}}
{"token": ["The", "results", "show", "that", "phospholipase", "C", "C3539768#ent", "<e1>", "activated", "by", "C2936795#ent", "<e2>"], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936795", "name": "C2936795#ent", "pos": [10, 11]}}
{"token": ["C0677829#ent", "<e1>", "Ras-dependent", "induction", "of", "p53", "was", "blocked", "by", "single", "allelic", "loss", "C1414293#ent", "<e2>", "as", "well", "as", "by", "suppression", "of", "C1414293#ent", "<e2>", "."], "h": {"id": "C0677829", "name": "C0677829#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414293", "name": "C1414293#ent", "pos": [12, 13]}}
{"token": ["Reduction", "of", "the", "intracellular", "C1260386#ent", "<e1>", "and", "NPSH", "levels", "in", "HeLa", "cells", "BSO", "and", "C1833296#ent", "<e2>", "treatments", "was", "determined", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1833296", "name": "C1833296#ent", "pos": [14, 15]}}
{"token": ["C1260386#ent", "<e1>", "depletion", "by", "two", "different", "modalities", ",", "diethylmaleate", "(", "C1833296#ent", "<e2>", ")", "and", "buthionine", "sulfoximine", "BSO", ")", ",", "results", "in", "thermal", "sensitization"], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1833296", "name": "C1833296#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", "to", "the", "benzazepine", "3b", "the", "C0021236#ent", "<e1>", "based", "test", "compounds", "out", "less", "selective", "over", "the", "C1415944#ent", "<e2>", "and", "D3", "receptor", "subtype", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415944", "name": "C1415944#ent", "pos": [17, 18]}}
{"token": ["Results", "from", "the", "in", "vitro", "assays", "that", "C0054224#ent", "<e1>", "in", "serum", "can", "completely", "prevent", "the", "establishment", "of", "C0039753#ent", "<e2>", "the", "first", "48", "h", "after", "administration", "at", "5", "mg", "kg(-1", ")", "."], "h": {"id": "C0054224", "name": "C0054224#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039753", "name": "C0039753#ent", "pos": [17, 18]}}
{"token": ["C1539794#ent", "<e1>", "is", "shown", "to", "exert", "a", "negative", "effect", "on", "C1332794#ent", "<e2>", "synthesis", ",", "rather", "than", "regulation", "of", "Csk", "mRNA", "levels", "or", "protein", "turnover"], "h": {"id": "C1539794", "name": "C1539794#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332794", "name": "C1332794#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "we", "have", "uncovered", "a", "previously", "uncharacterized", "role", "for", "C1539794#ent", "<e1>", "in", "the", "gene-specific", "translational", "control", "of", "C1332794#ent", "<e2>", "expression", "."], "h": {"id": "C1539794", "name": "C1539794#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332794", "name": "C1332794#ent", "pos": [18, 19]}}
{"token": ["While", "increased", "availability", "of", "C0235480#ent", "<e1>", "may", "reflect", "parasite", "burden", "and", "may", "modulate", "liver-mediated", "metabolic", "disturbances", "such", "as", "C0020616#ent", "<e2>", "and", "lactic", "acidosis", "the", "role", "of", "C0235480#ent", "<e1>", "in", "cerebral", "malaria", "uncertain", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [4, 5]}}
{"token": ["The", "mouse", "Unp", "gene", "is", "related", "to", "TRE17", ",", "a", "human", "C0029016#ent", "<e1>", ",", "but", "is", "not", "its", "C1412544#ent", "<e2>"], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412544", "name": "C1412544#ent", "pos": [18, 19]}}
{"token": ["The", "results", "of", "this", "study", "support", "that", "the", "tetracaine", "gels", "efficient", "anesthetic", "effects", "be", "developed", "using", "C0063242#ent", "<e1>", "and", "poloxamer", "with", "combination", "of", "enhancer", "and", "C0042397#ent", "<e2>", "."], "h": {"id": "C0063242", "name": "C0063242#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [25, 26]}}
{"token": ["A", "second", "experiment", "used", "male", "rats", "from", "the", "fourth", "generation", "to", "investigate", "the", "participation", "of", "the", "C0002707#ent", "<e1>", "during", "contextual", "fear", "conditioning", "the", "C0019099#ent", "<e2>", "and", "CLF", "lines", "."], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [23, 24]}}
{"token": ["TrnK(UUU", ")", ",", "C1419712#ent", "<e1>", "and", "trnQ(UUG", ")", "were", "located", "upstream", "of", "psbA.", "These", "C1417679#ent", "<e2>", "were", "transcribed", "from", "the", "same", "DNA", "strand", "psbA", "and", "multiple", "RNAs", "hybridized", "to", "them", "."], "h": {"id": "C1419712", "name": "C1419712#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}}
{"token": ["The", "cytoadhesion", "to", "C1706544#ent", "<e1>", "and", "CD36", "of", "IRBCs", "from", "uncomplicated", "and", "severe", "C0024530#ent", "<e2>", "attacks", "was", "evaluated", "using", "this", "methodology", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [13, 14]}}
{"token": ["We", "have", "established", "that", "C0172537#ent", "<e1>", "considerably", "potentiate", "the", "activation", "rate", "of", "C0255672#ent", "<e2>", "by", "crude", "plasma", "membrane", "from", "concanavalin", "A-stimulated", "fibroblasts", ",", "thus", "confirming", "our", "results", "using", "purified", "C0172537#ent", "<e1>", "MT1-MMP", "."], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0255672", "name": "C0255672#ent", "pos": [12, 13]}}
{"token": ["The", "role", "of", "various", "matrix", "metalloproteinases", "as", "C0172537#ent", "<e1>", ",", "stromelysins", ",", "matrilysin", ",", "C0255672#ent", "<e2>", ",", "and", "membrane-bound", "MMP", "(MB-MMP)--in", "tumor", "invasion", "metastasis", "is", "discussed", "."], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0255672", "name": "C0255672#ent", "pos": [14, 15]}}
{"token": ["We", "measured", "OPN", "level", "in", "tears", "using", "ELISA", ",", "to", "determine", "whether", "the", "level", "of", "this", "C1333196#ent", "<e1>", "is", "elevated", "in", "C0002873#ent", "<e2>", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002873", "name": "C0002873#ent", "pos": [21, 22]}}
{"token": ["In", "control", "rats", ",", "mean", "arterial", "pressure", "MAP", ")", "increased", ",", "RBF", "decreased", ",", "and", "renal", "vascular", "resistance", "C3540498#ent", "<e1>", ")", "increased", "in", "response", "to", "C0068821#ent", "<e2>", "infusion", "."], "h": {"id": "C3540498", "name": "C3540498#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0068821", "name": "C0068821#ent", "pos": [25, 26]}}
{"token": ["Spinal", "cord", "cauda", "equina", "diseases", "neuropathies", ",", "C0700594#ent", "<e1>", ",", "drugs", "and", "other", "C0085084#ent", "<e2>", "the", "main", "cause", "of", "this", "syndrome", "although", "many", "cases", "are", "still", "idiopathic", "."], "h": {"id": "C0700594", "name": "C0700594#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "neither", "losartan", "nor", "C0014027#ent", "<e1>", "is", "acutely", "C3537142#ent", "<e2>", "in", "hypertrophied", "rat", "hearts", "during", "low-flow", "ischaemia", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3537142", "name": "C3537142#ent", "pos": [10, 11]}}
{"token": ["These", "results", "demonstrate", "that", "missense", "mutations", "the", "C1415063#ent", "<e1>", "a", "cause", "of", "IGHD", "IB", "and", "that", "defects", "in", "the", "C1415063#ent", "<e1>", "be", "a", "more", "common", "cause", "of", "C0013338#ent", "<e1>", "previously", "suspected", "."], "h": {"id": "C1415063", "name": "C1415063#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0013338", "name": "C0013338#ent", "pos": [27, 28]}}
{"token": ["Inactivating", "mutations", "the", "GH-releasing", "hormone", "receptor", "(", "GHRHR", ")", "gene", "(", "C1415063#ent", "<e1>", ")", "cause", "familial", "isolated", "C0013338#ent", "<e2>", "IGHD", ")", "type", "IB", "."], "h": {"id": "C1415063", "name": "C1415063#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0013338", "name": "C0013338#ent", "pos": [17, 18]}}
{"token": ["The", "physicochemical", "and", "catalytic", "properties", "of", "this", "enzyme", "are", "common", "to", "the", "group", "of", "proteins", "called", "C1870389#ent", "<e1>", "among", "the", "family", "of", "C0599532#ent", "<e2>", ":", "disulfide", "oxidoreductases", "also", "includes", "thioredoxin", "and", "protein", "disulfide", "isomerase"], "h": {"id": "C1870389", "name": "C1870389#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0599532", "name": "C0599532#ent", "pos": [22, 23]}}
{"token": ["To", "identify", "the", "prevalence", ",", "seasonality", "and", "demographic", "characteristics", "patients", "with", "C0152517#ent", "<e1>", "we", "reviewed", "6", "years", "of", "retrospective", "data", "viral", "agents", "C0017160#ent", "<e2>", "screened", "by", "electron", "microscopy", "10", "centers", "in", "the", "United", "States", "Canada", "."], "h": {"id": "C0152517", "name": "C0152517#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0017160", "name": "C0017160#ent", "pos": [22, 23]}}
{"token": ["A", "new", "series", "of", "catechol", "hydrazines", "synthesized", "and", "their", "structure-activity", "relationship", "C4283882#ent", "<e1>", ")", "was", "analyzed", "for", "developing", "an", "effective", "C0031640#ent", "<e2>", "PDE4", ")", "inhibitor", "as", "an", "anti-asthmatic", "drug", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [20, 21]}}
{"token": ["Moreover", "the", "NA-induced", "inhibition", "of", "swallowing", ",", "was", "significantly", "antagonized", "by", "pretreatment", "with", "the", "alpha-adrenergic", "blocker", "C0031448#ent", "<e1>", "applied", "locally", "in", "the", "C1332110#ent", "<e2>", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332110", "name": "C1332110#ent", "pos": [22, 23]}}
{"token": ["The", "direct", "inotropic", "actions", "of", "ethmozine", "and", "of", "its", "diethylamine", "analog", "C0057941#ent", "<e1>", ",", "were", "studied", "in", "the", "presence", "of", "muscarinic", "and", "C0001641#ent", "<e2>", "12", "ferret", "right", "ventricular", "papillary", "muscles"], "h": {"id": "C0057941", "name": "C0057941#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [22, 23]}}
{"token": ["Genes", "encoding", "enzymes", "such", "as", "glutamate/aspartate", "transporter", "C1420121#ent", "<e1>", ")", ",", "nitric", "oxide", "synthetase", "NOS", ")", "and", "prostaglandin", "G/H", "synthetase", "C1705323#ent", "<e2>", ")", "are", "identified", "as", "mechanical", "stress-responsive"], "h": {"id": "C1420121", "name": "C1420121#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [20, 21]}}
{"token": ["A", "study", "was", "designed", "to", "assess", "the", "scintigraphic", "criteria", "for", "diagnosis", "of", "C0151451#ent", "<e1>", "to", "evaluate", "the", "relationship", "of", "C0151451#ent", "<e1>", "gluteus", "medius", "tendinitis", "C0263874#ent", "<e1>", "predicting", "relapse", "after", "injection", "."], "h": {"id": "C0151451", "name": "C0151451#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0263874", "name": "C0263874#ent", "pos": [24, 25]}}
{"token": ["Both", "matrix", "metalloproteinase-2", "MMP-2", ")", "and", "-9", "(", "MMP-9", ")", "have", "been", "postulated", "to", "play", "roles", "in", "the", "pathophysiology", "of", "C0039483#ent", "<e1>", "GCA", ")", "because", "of", "their", "ability", "to", "degrade", "C0013765#ent", "<e2>", "."], "h": {"id": "C0039483", "name": "C0039483#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [30, 31]}}
{"token": ["To", "understand", "the", "metabolic", "and", "temporal", "links", "in", "the", "relationship", "between", "C0011849#ent", "<e1>", "and", "depression", ",", "we", "determined", "the", "association", "between", "C0086132#ent", "<e2>", "unrecognized", "glucose", "intolerance"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086132", "name": "C0086132#ent", "pos": [21, 22]}}
{"token": ["C0215906#ent", "<e1>", "(", "10(-7)-10(-5", ")", "M", ")", "and", "C0059752#ent", "<e2>", "(", "10(-7)-10(-5", ")", "M", ")", "inhibited", "the", "64", "mM", "KCl-induced", "and", "10(-6)M", "norepinephrine", "(NE)-induced", "contraction", "of", "rat", "aortic", "strips", "."], "h": {"id": "C0215906", "name": "C0215906#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059752", "name": "C0059752#ent", "pos": [8, 9]}}
{"token": ["C0215906#ent", "<e1>", ",", "but", "not", "C0059752#ent", "<e2>", ",", "attenuated", "the", "age-related", "decreased", "step", "through", "latency", "(", "STL", ")", "on", "a", "passive", "avoidance", "task", "."], "h": {"id": "C0215906", "name": "C0215906#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059752", "name": "C0059752#ent", "pos": [5, 6]}}
{"token": ["Itraconazole", "was", "reported", "to", "be", "metabolized", "via", "C3714798#ent", "<e1>", "to", "several", "metabolites", ",", "including", "C0249851#ent", "<e2>", ",", "in", "human", "subjects", "."], "h": {"id": "C3714798", "name": "C3714798#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0249851", "name": "C0249851#ent", "pos": [14, 15]}}
{"token": ["Selected", "representative", "C2697656#ent", "<e1>", "included", "flavonoids", "(", "quercetin", ",", "rutin", ",", "and", "C0007404#ent", "<e2>", ")", ",", "resveratrol", ",", "tannic", "acid", "and", "phenolic", "acids", "gallic", ",", "caffeic", ",", "and", "ferulic", ")", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007404", "name": "C0007404#ent", "pos": [12, 13]}}
{"token": ["Using", "patch", "clamp", "the", "cell-attached", "configuration", ",", "we", "characterized", "the", "store-operated", "channels", "C1332762#ent", "<e1>", ")", "and", "the", "stretch-activated", "channels", "C1849140#ent", "<e2>", ")", "present", "in", "isolated", "mouse", "skeletal", "muscle"], "h": {"id": "C1332762", "name": "C1332762#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1849140", "name": "C1849140#ent", "pos": [19, 20]}}
{"token": ["Of", "the", "38", "patients", "who", "were", "diagnosed", "with", "C0025289#ent", "<e1>", "eight", "also", "experienced", "C0007785#ent", "<e2>"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [13, 14]}}
{"token": ["PDGF-AB", "distinctively", "upregulated", "C0009325#ent", "<e1>", "expression", ",", "while", "PDGF-BB", "primarily", "seemed", "to", "be", "C0026249#ent", "<e2>", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "T", "cells", "for", "24", "hours", "to", "C0009325#ent", "<e1>", "capable", "of", "suppressing", "B-cell", "responsiveness", "to", "C0026249#ent", "<e2>", "in", "autologous", "mixed", "lymphocyte", "cultures", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [16, 17]}}
{"token": ["The", "statistical", "analysis", "correlation", "showed", "positive", "resistance", "between", "C0003205#ent", "<e1>", "(", "cetrimide", ",", "chlorhexidine", ",", "C0019435#ent", "<e2>", ")", "or", "between", "these", "C0003205#ent", "<e1>", "and", "antibiotics", "for", "S", "marcescens", "Alcaligenes", "."], "h": {"id": "C0019435", "name": "C0019435#ent", "pos": [15, 16]}, "relation": "has_therapeutic_class", "t": {"id": "C0003205", "name": "C0003205#ent", "pos": [8, 9]}}
{"token": ["Young", "rats", "6", "to", "22", "days", "of", "age", "are", "extremely", "susceptible", "to", "the", "neurotoxic", "effects", "C0019435#ent", "<e1>", "given", "as", "a", "daily", "bath", "undiluted", "C0003205#ent", "<e2>", "3", "%", "C0019435#ent", "<e1>", "(", "pHiso-Hex", ")", "."], "h": {"id": "C0019435", "name": "C0019435#ent", "pos": [15, 16]}, "relation": "has_therapeutic_class", "t": {"id": "C0003205", "name": "C0003205#ent", "pos": [23, 24]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "the", "activity", "of", "a", "key", "C0537969#ent", "<e1>", "caspase-3", ",", "and", "the", "expression", "of", "C0907533#ent", "<e2>", "NOS-2", ")", "associated", "with", "buccal", "epithelial", "cells", "apoptosis", "induced", "by", "chronic", "ethanol", "diet", "."], "h": {"id": "C0537969", "name": "C0537969#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [19, 20]}}
{"token": ["Real-time", "polymerase", "chain", "reaction", "analysis", "that", "known", "hypoxia-responsive", "genes", "as", "C1335837#ent", "<e1>", "vascular", "endothelial", "growth", "factor", "induced", "in", "a", "C1333897#ent", "<e2>", "manner", "under", "hypoxia", "."], "h": {"id": "C1335837", "name": "C1335837#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [19, 20]}}
{"token": ["C1335837#ent", "<e1>", "GLUT-1", ")", ",", "a", "downstream", "product", "of", "C1333897#ent", "<e2>", "activation", ",", "is", "over-expressed", "in", "a", "variety", "of", "human", "tumours", "."], "h": {"id": "C1335837", "name": "C1335837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "in", "a", "heterologous", "expression", "system", "C1540033#ent", "<e1>", "altered", "the", "distribution", "of", "BNC1", "channels", "this", "effect", "was", "dependent", "on", "the", "PDZ", "domain", "C1540033#ent", "<e1>", "and", "the", "C-terminus", "of", "C1412114#ent", "<e1>", "."], "h": {"id": "C1540033", "name": "C1540033#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412114", "name": "C1412114#ent", "pos": [30, 31]}}
{"token": ["These", "data", "suggest", "that", "C1540033#ent", "<e1>", "binds", "ASIC", "and", "C1412114#ent", "<e2>", "via", "its", "PDZ", "domain"], "h": {"id": "C1540033", "name": "C1540033#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412114", "name": "C1412114#ent", "pos": [9, 10]}}
{"token": ["We", "report", "that", "ced-10", ",", "mig-2", "and", "C3539738#ent", "<e1>", "act", "redundantly", "in", "axon", "pathfinding", "inactivating", "one", "C0017337#ent", "<e2>", "had", "little", "effect", ",", "but", "inactivating", "two", "or", "more", "genes", "perturbed", "both", "axon", "outgrowth", "guidance", "."], "h": {"id": "C3539738", "name": "C3539738#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["Examples", "of", "the", "first", "category", "include", "C0004134#ent", "<e1>", "with", "isolated", "vitamin", "E", "deficiency", "abetalipoproteinemia", ",", "Refsum's", "disease", "C1849096#ent", "<e2>", "and", "C0004134#ent", "<e1>", "with", "blindness", "and", "deafness", "."], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C1849096", "name": "C1849096#ent", "pos": [17, 18]}}
{"token": ["Stat3-dependent", "cell", "death", "during", "involution", "can", "be", "blocked", "by", "activation", "of", "Akt/protein", "kinase", "B", "(", "C1705341#ent", "<e1>", ")", ",", "a", "downstream", "effector", "of", "the", "C1418575#ent", "<e2>", "PI(3)K", ")", "pathway", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418575", "name": "C1418575#ent", "pos": [24, 25]}}
{"token": ["Furthermore", ",", "in", "a", "case", "of", "IgM", "type", "M", "protein", ",", "C1706005#ent", "<e1>", "level", "was", "twice", "higher", "by", "LAIA", "than", "that", "by", "C0007787#ent", "<e2>", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [22, 23]}}
{"token": ["Although", "only", "a", "limited", "number", "of", "data", "points", "be", "obtained", "from", "serial", "muscle", "biopsies", "no", "delay", "the", "rate", "of", "activation", "of", "C1364081#ent", "<e1>", "was", "apparent", "in", "the", "obese", "and", "C3273872#ent", "<e2>", "groups", "."], "h": {"id": "C1364081", "name": "C1364081#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [29, 30]}}
{"token": ["Our", "limited", "study", "suggests", "that", "elderly", "East", "Africans", "C0221505#ent", "<e1>", "in", "AD", "subjects", "but", "the", "C0052199#ent", "<e2>", "not", "be", "a", "highly", "specific", "factor", "for", "the", "disease", "among", "East", "Africans"], "h": {"id": "C0221505", "name": "C0221505#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0052199", "name": "C0052199#ent", "pos": [15, 16]}}
{"token": ["We", "conclude", "that", "cultures", "of", "human", "proximal", "C0151747#ent", "<e1>", "intact", "human", "PIIINP", "by", "the", "formation", "of", "high-", "and", "C0019139#ent", "<e2>"], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [18, 19]}}
{"token": ["Both", "C0073561#ent", "<e1>", "or", "diazepam", "were", "equipotent", "and", "more", "effective", "than", "C0128513#ent", "<e2>", "in", "potentiating", "the", "inotropic", "effect", "noradrenaline", "whereas", "EHNA", "and", "MIMX", "had", "no", "effect"], "h": {"id": "C0073561", "name": "C0073561#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0128513", "name": "C0128513#ent", "pos": [11, 12]}}
{"token": ["In", "a", "third", "phase", ",", "if", "animals", "are", "re-challenged", "with", "mercuric", "chloride", "weeks", "later", ",", "they", "show", "only", "attenuated", "autoimmunity", "with", "lower", "C1332309#ent", "<e1>", "concentrations", "and", "C0003864#ent", "<e2>"], "h": {"id": "C1332309", "name": "C1332309#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [26, 27]}}
{"token": ["The", "purpose", "of", "the", "study", "was", "to", "evaluate", "the", "effects", "of", "C0247025#ent", "<e1>", "on", "clinical", "stabilization", "parameters", "in", "patients", "with", "C0002965#ent", "<e2>", "UA", ")", "and", "non-Q-wave", "myocardial", "infarction", "(", "MI", ")", "."], "h": {"id": "C0247025", "name": "C0247025#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [20, 21]}}
{"token": ["In", "the", "C1825292#ent", "<e1>", "-", "1", "mutant", "the", "electron", "transport", "C1176474#ent", "<e2>", "strongly", "reduced", ",", "whereas", "Complex", "IV", "functional", ",", "indicating", "that", "PPR40", "is", "important", "for", "the", "ubiqinol-cytochrome", "c", "oxidoreductase", "activity", "C1176474#ent", "<e2>"], "h": {"id": "C1825292", "name": "C1825292#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1176474", "name": "C1176474#ent", "pos": [10, 11]}}
{"token": ["A", "case", "of", "gingival", "hyperplasia", "a", "subject", "suffering", "from", "tuberous", "sclerosis", "had", "never", "received", "C0020208#ent", "<e1>", "for", "the", "control", "of", "C0014544#ent", "<e2>", "is", "presented", "."], "h": {"id": "C0020208", "name": "C0020208#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [20, 21]}}
{"token": ["C0020208#ent", "<e1>", "should", "therefore", "be", "strictly", "avoided", "in", "C0014544#ent", "<e2>", "women", "of", "child-bearing", "age", "unless", "safe", "contraceptive", "measures", "taken", "."], "h": {"id": "C0020208", "name": "C0020208#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [8, 9]}}
{"token": ["The", "enhancement", "of", "the", "antinociceptive", "activity", "C0000254#ent", "<e1>", "and", "MK-801", "by", "glycine", "and", "C0031957#ent", "<e2>", ",", "respectively", ",", "was", "not", "accompanied", "by", "increases", "in", "motor", "dysfunction"], "h": {"id": "C0000254", "name": "C0000254#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [13, 14]}}
{"token": ["Four", "of", "the", "6", "human", "C1417326#ent", "<e1>", "in", "this", "study", "mapped", "to", "chromosome", "11q12-q13.1", "with", "C3272788#ent", "<e2>", ",", "FcepsilonRIbeta", ",", "and", "HTm4", "."], "h": {"id": "C1417326", "name": "C1417326#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3272788", "name": "C3272788#ent", "pos": [15, 16]}}
{"token": ["C1366897#ent", "<e1>", "is", "a", "new", "member", "of", "the", "C0031727#ent", "<e2>", "and", "is", "expressed", "at", "its", "highest", "levels", "in", "skeletal", "muscle"], "h": {"id": "C1366897", "name": "C1366897#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}}
{"token": ["After", "examination", "of", "the", "different", "patterns", "of", "C3470196#ent", "<e1>", "markers", "as", "diagnostic", "tools", "B19", "infection", "C1706005#ent", "<e2>", "determination", "detected", "only", "60", "%", "of", "B19-documented", "infections", "."], "h": {"id": "C3470196", "name": "C3470196#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [15, 16]}}
{"token": ["These", "observations", "suggest", "the", "involvement", "of", "C3889249#ent", "<e1>", "in", "human", "C1415831#ent", "<e2>", "gene", "regulation", "which", "seems", "to", "be", "mediated", "through", "at", "least", "two", "A", "element-like", "cis-motifs", "in", "the", "gene", "promoter"], "h": {"id": "C3889249", "name": "C3889249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415831", "name": "C1415831#ent", "pos": [10, 11]}}
{"token": ["C1366529#ent", "<e1>", "from", "the", "cell", "surface", "the", "sialyltransferase", "compartment", "of", "the", "C1423498#ent", "<e2>", "with", "a", "half-time", "of", "2.5", "h", "in", "K562", "human", "leukemia", "cells", "expressing", "receptor", "from", "a", "transfected", "cDNA", "."], "h": {"id": "C1366529", "name": "C1366529#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423498", "name": "C1423498#ent", "pos": [11, 12]}}
{"token": ["As", "measured", "by", "the", "INR", ",", "there", "is", "no", "apparent", "effect", "of", "C0287041#ent", "<e1>", "on", "the", "C3536711#ent", "<e2>", "effect", "of", "warfarin", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [16, 17]}}
{"token": ["injections", "of", "C0033321#ent", "<e1>", ",", "a", "CCK", "receptor", "antagonist", "on", "the", "central", "effects", "C1424808#ent", "<e2>", "."], "h": {"id": "C0033321", "name": "C0033321#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424808", "name": "C1424808#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesized", "that", "C1539327#ent", "<e1>", "is", "associated", "with", "plaque", "phenotypes", "and", "that", "plasma", "C1539327#ent", "<e1>", "could", "serve", "as", "biomarker", "for", "C0003850#ent", "<e1>", "."], "h": {"id": "C1539327", "name": "C1539327#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [20, 21]}}
{"token": ["Swine", "inoculated", "intranasally", "with", "a", "mixture", "of", "human", "influenza", "virus", "H.", "influenzae", "suis", "develop", "a", "C0015967#ent", "<e1>", ",", "depressing", "illness", "similar", "to", "C2076600#ent", "<e2>"], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2076600", "name": "C2076600#ent", "pos": [22, 23]}}
{"token": ["We", "isolated", "the", "murine", "LIM", "protein", "HIC-5", "(", "C3811704#ent", "<e1>", ";", "also", "termed", "ARA-55", "(", "C1420710#ent", "<e2>", "55", "kDa", ")", ")", "and", "cloned", "the", "highly", "conserved", "Xenopus", "homolog"], "h": {"id": "C3811704", "name": "C3811704#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420710", "name": "C1420710#ent", "pos": [15, 16]}}
{"token": ["C3811704#ent", "<e1>", "ARA70", ")", "is", "a", "reported", "C1420710#ent", "<e2>", "enhances", "the", "transactivational", "potential", "of", "the", "androgen", "receptor", "to", "10-fold", "."], "h": {"id": "C3811704", "name": "C3811704#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420710", "name": "C1420710#ent", "pos": [7, 8]}}
{"token": ["Emergency", "physicians", "to", "be", "aware", "of", "the", "uncommon", "occurrence", "of", "C0016365#ent", "<e1>", "cardiotoxicity", "and", "the", "potential", "benefit", "of", "C0074722#ent", "<e2>"], "h": {"id": "C0016365", "name": "C0016365#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0074722", "name": "C0074722#ent", "pos": [18, 19]}}
{"token": ["C0032950#ent", "<e1>", "showed", "no", "defleecing", "activity", "whereas", "the", "other", "C0038317#ent", "<e2>", "produced", "positive", "but", "variable", "responses", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [9, 10]}}
{"token": ["We", "asked", "whether", "the", "structural", "homology", "confers", "the", "capacity", "to", "compete", "for", "the", "membrane-binding", "sites", "of", "C1366370#ent", "<e1>", "factor", "V", "to", "function", "as", "an", "C3536711#ent", "<e2>", "."], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [24, 25]}}
{"token": ["Interestingly", ",", "P17", "and", "C1412677#ent", "<e1>", "elicited", "both", "Th1", "and", "Th2", "cell", "with", "significant", "numbers", "of", "C1334103#ent", "<e2>", "secreting", "clones", "in", "response", "to", "stimulation", "."], "h": {"id": "C1412677", "name": "C1412677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334103", "name": "C1334103#ent", "pos": [16, 17]}}
{"token": ["Papillon-Lef\u00e8vre", "syndrome", "C0030360#ent", "<e1>", ")", "is", "an", "autosomal", "recessive", "palmoplantar", "keratoderma", "by", "cathepsin", "C", "C1413811#ent", "<e2>", ")", "gene", "mutations"], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413811", "name": "C1413811#ent", "pos": [14, 15]}}
{"token": ["The", "Saccharomyces", "cerevisiae", "C3812695#ent", "<e1>", "Gpr1", "and", "associated", "C0887847#ent", "<e2>", "Gpa2", "sense", "extracellular", "carbon", "sources", "(", "including", "glucose", ")", "to", "govern", "filamentous", "growth"], "h": {"id": "C3812695", "name": "C3812695#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0887847", "name": "C0887847#ent", "pos": [8, 9]}}
{"token": ["The", "C1332012#ent", "<e1>", "most", "of", "the", "biological", "effects", "IGF-I", "and", "C1334091#ent", "<e2>", ";", "the", "type", "2", "receptor", "involved", "with", "C1334091#ent", "<e2>", "degradation", "."], "h": {"id": "C1332012", "name": "C1332012#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334091", "name": "C1334091#ent", "pos": [10, 11]}}
{"token": ["The", "currently", "available", "vaccines", "for", "C0042769#ent", "<e1>", "Dryvax", "for", "C0037354#ent", "<e2>", ";", "the", "combination", "measles", "mumps", ",", "and", "rubella", "vaccine", "inactivated", "vaccine", "for", "hepatitis", "A", "plasma-derived", "vaccine", "for", "hepatitis", "B", "and", "the", "live", "attenuated", "Oka", "strain", "vaccine", "varicella", "zoster"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0037354", "name": "C0037354#ent", "pos": [9, 10]}}
{"token": ["Lignans", "are", "widely", "existed", "in", "natural", "world", "a", "variety", "of", "structures", "and", "bioactivities", ",", "including", "C0003392#ent", "<e1>", ",", "antiinflammatory", ",", "anti-viral", "and", "C1512412#ent", "<e2>", "properties", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1512412", "name": "C1512412#ent", "pos": [22, 23]}}
{"token": ["This", "is", "the", "first", "evidence", "that", ",", "when", "oncogenically", "activated", ",", "p21ras", "and", "C3853644#ent", "<e1>", "not", "only", "exert", "a", "negative", "control", "C1334133#ent", "<e2>", "also", "repress", "insulin", "receptor", "gene", "expression", "in", "human", "colonic", "cells"], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [21, 22]}}
{"token": ["One", "of", "the", "exudates", "specifically", "inhibited", "tyrosyl", "phosphorylation", "p68gag-ros", "but", "not", "the", "activity", "of", "other", "known", "tyrosyl", "kinases", "such", "as", "p150gag-fps", "of", "UR1", "avian", "sarcoma", "virus", "C3853644#ent", "<e1>", ",", "and", "the", "C1334133#ent", "<e2>"], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [31, 32]}}
{"token": ["Chronic", "(", "10-day", ")", "C0011847#ent", "<e1>", "was", "associated", "with", "increased", "metabolic", "flux", "through", "C1418251#ent", "<e2>", "isolated", "liver", "cells"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418251", "name": "C1418251#ent", "pos": [13, 14]}}
{"token": ["CD4+CD45RA-", "T", "cells", "expressed", "proportionally", "more", "C1420369#ent", "<e1>", "and", "beta7", "integrins", "L-selectin", "in", "regional", "C1538915#ent", "<e2>", "and", "RLN", ",", "but", "also", "in", "PSLN", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538915", "name": "C1538915#ent", "pos": [14, 15]}}
{"token": ["We", "used", "C0031008#ent", "<e1>", "to", "treat", "10", "patients", "with", "C0030567#ent", "<e2>", "had", "first", "responded", "to", ",", "and", "then", "failed", ",", "bromocriptine", "therapy"], "h": {"id": "C0031008", "name": "C0031008#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [9, 10]}}
{"token": ["Cleavage", "of", "collagens", "in", "the", "organic", "matrix", "subchondral", "bone", "cartilage", "by", "C2717970#ent", "<e1>", "such", "as", "C0284930#ent", "<e2>", "may", "be", "one", "possible", "mechanism", "."], "h": {"id": "C2717970", "name": "C2717970#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0284930", "name": "C0284930#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "notwithstanding", "the", "importance", "of", "the", "autoimmune", "reactivity", "MBP", "and", "PLP", "in", "C0026269#ent", "<e1>", ",", "the", "potentially", "pathogenic", "autoimmune", "reactivity", "C1417228#ent", "<e2>", "must", "now", "also", "be", "taken", "into", "consideration", "in", "therapeutic", "approaches", "C0026269#ent", "<e1>", "."], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417228", "name": "C1417228#ent", "pos": [21, 22]}}
{"token": ["The", "PAF", "antagonist", "C0056628#ent", "<e1>", "partially", "reversed", "the", "PAF", "induced", "effects", "on", "HTGL", ",", "C3272447#ent", "<e2>", "and", "PL", "."], "h": {"id": "C0056628", "name": "C0056628#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3272447", "name": "C3272447#ent", "pos": [14, 15]}}
{"token": ["The", "C1537486#ent", "<e1>", ",", "v-Raf-responsive", "elements", "of", "rep-3b", "and", "C1823242#ent", "<e2>", "bind", "the", "general", "transcription", "factor", "Sp1", "in", "electromobility", "shift", "assays"], "h": {"id": "C1537486", "name": "C1537486#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823242", "name": "C1823242#ent", "pos": [9, 10]}}
{"token": ["Mechanical", "stretch", "labor", "and", "C0038317#ent", "<e1>", "differentially", "regulated", "C1414160#ent", "<e2>", "and", "TCTE1L", "mRNA", "in", "the", "pregnant", "and", "non-pregnant", "sheep", "myometrium", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414160", "name": "C1414160#ent", "pos": [8, 9]}}
{"token": ["The", "marked", "inhibitory", "effects", "of", "leupeptin", ",", "antipain", "and", "C0055676#ent", "<e1>", "suggest", "that", "cathepsin", "B", "possibly", "C1332807#ent", "<e2>", "in", "the", "degradation", "of", "125I-labelled", "albumin", "in", "yolk", "sacs"], "h": {"id": "C0055676", "name": "C0055676#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [16, 17]}}
{"token": ["The", "enhanced", "green", "fluorescent", "protein", "red", "fluorescent", "protein", "and", "severe", "acute", "respiratory", "syndrome", "coronavirus", "envelope", "protein", "used", "as", "model", "proteins", "and", "were", "selectively", "and", "functionally", "C2350558#ent", "<e1>", "to", "the", "C0030779#ent", "<e2>", "microbeads", "by", "fusing", "them", "to", "the", "SBD", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [29, 30]}}
{"token": ["Porphyria", "cutanea", "tarda", "PCT", ")", "is", "an", "unfrequent", "disorder", "in", "patients", "with", "C0001175#ent", "<e1>", "AIDS", ")", "due", "to", "deficiency", "in", "C0042085#ent", "<e2>"], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042085", "name": "C0042085#ent", "pos": [20, 21]}}
{"token": ["We", "show", "that", "the", "Paf1", "complex", "is", "required", "for", "recruitment", "of", "the", "COMPASS", "methyltransferase", "C0035679#ent", "<e1>", "that", "the", "subunits", "of", "these", "complexes", "interact", "physically", "and", "C1516876#ent", "<e2>", "."], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [25, 26]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "define", "pelvic", "floor", "function", "patients", "with", "multiple", "sclerosis", "bowel", "dysfunction", "either", "C0015732#ent", "<e1>", "(", "MSI", ")", "or", "defecation", "difficulties", "without", "C0015732#ent", "<e1>", "(", "C0074299#ent", "<e1>", ")", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0074299", "name": "C0074299#ent", "pos": [30, 31]}}
{"token": ["We", "used", "the", "bacterial", "C2346475#ent", "<e1>", "Nocardia", "rubra", "cell", "wall", "skeleton", "N-CWS", ")", ",", "and", "a", "streptococcal", "preparation", "C0918027#ent", "<e2>", ",", "for", "MCA", "102", "and", "BL6", ",", "respectively", "."], "h": {"id": "C2346475", "name": "C2346475#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0918027", "name": "C0918027#ent", "pos": [18, 19]}}
{"token": ["Forty-six", "(", "96", "%", ")", "of", "the", "C1332416#ent", "<e1>", "patients", "were", "seizure", "free", "or", "had", "reduced", "C0751495#ent", "<e2>", "as", "of", "their", "last", "follow-up", "examination", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [16, 17]}}
{"token": ["ClpB", "is", "a", "member", "of", "a", "multichaperone", "system", "in", "Escherichia", "coli", "with", "DnaK", ",", "DnaJ", ",", "and", "C1426341#ent", "<e1>", ")", "that", "reactivates", "aggregated", "C0086376#ent", "<e2>", "."], "h": {"id": "C1426341", "name": "C1426341#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [23, 24]}}
{"token": ["In", "Escherichia", "coli", "the", "molecular", "chaperones", "DnaK", ",", "DnaJ", ",", "and", "C1426341#ent", "<e1>", ")", "are", "essential", "for", "the", "rapid", "degradation", "of", "certain", "C0086376#ent", "<e2>", "."], "h": {"id": "C1426341", "name": "C1426341#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [22, 23]}}
{"token": ["The", "C2945601#ent", "<e1>", "amlodipine", "and", "the", "C0815017#ent", "<e2>", "irbesartan", "effectively", "reduce", "blood", "pressure", "hypertensive", "children", "."], "h": {"id": "C2945601", "name": "C2945601#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0815017", "name": "C0815017#ent", "pos": [6, 7]}}
{"token": ["We", "found", "that", "the", "anti-PLC-delta", "antibody", "stained", "neuronal", "inclusions", "of", "C0338451#ent", "<e1>", "progressive", "supranuclear", "palsy", "diffuse", "Lewy", "body", "disease", "the", "inclusions", "of", "idiopathic", "Parkinson's", "disease", "C1870412#ent", "<e2>", "accumulation", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1870412", "name": "C1870412#ent", "pos": [25, 26]}}
{"token": ["Furthermore", ",", "we", "show", "that", "beta1-integrins", "and", "C1418667#ent", "<e1>", "ligands", "for", "C1419959#ent", "<e2>", "and", "that", "signaling", "by", "these", "receptors", "has", "opposing", "effects", "on", "Semaphorin", "7a-induced", "dendrite", "formation", "."], "h": {"id": "C1418667", "name": "C1418667#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419959", "name": "C1419959#ent", "pos": [11, 12]}}
{"token": ["A", "unique", "clone", "was", "obtained", "(", "C3889128#ent", "<e1>", ")", "which", "encoded", "a", "peptide", "homologous", "to", "porcine", "C2982014#ent", "<e2>", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2982014", "name": "C2982014#ent", "pos": [16, 17]}}
{"token": ["A", "4.0", "kB", "Hind", "III", "fragment", "of", "C3889128#ent", "<e1>", "containing", "the", "entire", "C2982014#ent", "<e2>", "precursor", "coding", "region", "hybridized", "against", "blots", "of", "EcoRI", "digested", "human", "genomic", "DNA"], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2982014", "name": "C2982014#ent", "pos": [12, 13]}}
{"token": ["Amongst", "the", "C0086376#ent", "<e1>", "that", "are", "subjected", "to", "variation", "during", "the", "C0080054#ent", "<e2>", "are", "under", "hormonal", "regulation"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [11, 12]}}
{"token": ["The", "identification", "of", "a", "family", "of", "C0086376#ent", "<e1>", "that", "stoichiometrically", "regulate", "the", "activation", "of", "the", "C0080054#ent", "<e2>", "added", "to", "our", "understanding", "of", "the", "process", "of", "commitment", "to", "the", "mitotic", "cycle"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [15, 16]}}
{"token": ["Results", "showed", "that", "the", "addition", "of", "C0535308#ent", "<e1>", "alone", "did", "not", "promote", "angiogenesis", "while", "C0919506#ent", "<e2>", "alone", "did", "."], "h": {"id": "C0535308", "name": "C0535308#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0919506", "name": "C0919506#ent", "pos": [14, 15]}}
{"token": ["Clonazepam", ",", "oxazepam", ",", "chlordiazepoxide", ",", "C1564434#ent", "<e1>", "and", "bromazepam", "had", "comparatively", "minor", "effects", "on", "both", "C3541394#ent", "<e2>"], "h": {"id": "C1564434", "name": "C1564434#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["Compared", "to", "other", "molecular", "probes", "tested", ",", "the", "C0079068#ent", "<e1>", "signals", "were", "more", "C0039070#ent", "<e2>", "and", "the", "quality", "of", "the", "preparation", "was", "less", "optimal", "than", "other", "tumor", "specimens", "we", "previously", "studied", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039070", "name": "C0039070#ent", "pos": [13, 14]}}
{"token": ["The", "C0022202#ent", "<e1>", "efficacy", "of", "the", "oxidoreductase", ",", "C0072354#ent", "<e2>", "PDI", ")", ",", "has", "been", "examined", "by", "a", "simple", "method", "."], "h": {"id": "C0022202", "name": "C0022202#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0072354", "name": "C0072354#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "C0022202#ent", "<e1>", "belonging", "to", "the", "C0072354#ent", "<e2>", "the", "production", "of", "free", "thiols", "F", "protein", "and", "free", "thiols", "F", "protein", "membrane", "fusion", "by", "F", "protein"], "h": {"id": "C0022202", "name": "C0022202#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0072354", "name": "C0072354#ent", "pos": [9, 10]}}
{"token": ["Although", "the", "mechanisms", "underlying", "diminished", "vitamin", "A", "the", "CRBP-null", "mice", "have", "not", "been", "elucidated", ",", "the", "observations", "support", "the", "model", "of", "C1332008#ent", "<e1>", "as", "a", "C1332924#ent", "<e2>", "of", "retinoid", "metabolism"], "h": {"id": "C1332008", "name": "C1332008#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1332924", "name": "C1332924#ent", "pos": [25, 26]}}
{"token": ["C1524023#ent", "<e1>", "(", "Scatter", "factor", "1", "and", "MSP", "(", "C1567780#ent", "<e2>", "bind", "to", "tyrosine", "kinase", "receptors", "encoded", "by", "the", "proto-oncogenes", "MET", "and", "RON", "."], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1567780", "name": "C1567780#ent", "pos": [9, 10]}}
{"token": ["Exogenous", "C3536742#ent", "<e1>", "exposure", "has", "been", "associated", "with", "C1456378#ent", "<e2>", "MAPK", ")", "and", "cardiac", "hypertrophy"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [8, 9]}}
{"token": ["Pancreatic", "NE", "GLIR", "spillover", "were", "also", "increased", "during", "severe", "C0020616#ent", "<e1>", "when", "ganglionic", "neurotransmission", "was", "partially", "impaired", "with", "C0062637#ent", "<e2>", "but", "not", "when", "the", "neural", "pathway", "interrupted", "by", "spinal", "cord", "transection"], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0062637", "name": "C0062637#ent", "pos": [18, 19]}}
{"token": ["The", "concentrations", "of", "SAA", "and", "C1879974#ent", "<e1>", "were", "markedly", "elevated", "in", "C1334513#ent", "<e2>", "patients", "but", "were", "not", "statistically", "different", "in", "LL/BL", "patients", "compared", "to", "control", "subjects"], "h": {"id": "C1879974", "name": "C1879974#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334513", "name": "C1334513#ent", "pos": [11, 12]}}
{"token": ["C1414685#ent", "<e1>", "is", "a", "transcription", "factor", ",", "when", "C3890227#ent", "<e2>", "into", "hepatocytes", ",", "accelerates", "the", "cell", "cycle", "maintains", "the", "hepatocyte", "in", "vivo", "proliferative", "capacity", "of", "aged", "livers", "."], "h": {"id": "C1414685", "name": "C1414685#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890227", "name": "C3890227#ent", "pos": [8, 9]}}
{"token": ["Gallium", "nitrate", "an", "antitumor", "agent", "noncytotoxic", "to", "osteoclasts", "and", "bone", "cells", "appears", "to", "be", "more", "effective", "than", "pamidronate", ",", "C0037507#ent", "<e1>", ",", "and", "calcitonin", "in", "the", "treatment", "of", "C0020437#ent", "<e2>"], "h": {"id": "C0037507", "name": "C0037507#ent", "pos": [19, 20]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [28, 29]}}
{"token": ["Mithramycin", "can", "lower", "the", "serum", "calcium", "concentration", "the", "new", "diphosphonates", "(", "C0037507#ent", "<e1>", "are", "very", "effective", "in", "the", "treatment", "of", "this", "C0020437#ent", "<e2>", "."], "h": {"id": "C0037507", "name": "C0037507#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [21, 22]}}
{"token": ["We", "have", "investigated", "the", "reaction", "pathways", "in", "the", "unseeded", "electroless", "deposition", "of", "copper", "on", "self-assembled", "monolayers", "(", "C1865361#ent", "<e1>", ")", "adsorbed", "on", "C0263505#ent", "<e2>", ",", "using", "time-of-flight", "secondary", "ion", "mass", "spectrometry", "optical", "microscopy", "and", "scanning", "electron", "microscopy"], "h": {"id": "C1865361", "name": "C1865361#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0263505", "name": "C0263505#ent", "pos": [22, 23]}}
{"token": ["Aromatic", "alkanedithiol", "C1865361#ent", "<e1>", "were", "firstly", "formed", "on", "C0263505#ent", "<e2>", "sensor", "surface", "and", "TNT", "analogues", "were", "immobilized", "on", "it", "through", "OEG", "chain", "."], "h": {"id": "C1865361", "name": "C1865361#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0263505", "name": "C0263505#ent", "pos": [8, 9]}}
{"token": ["2", "The", "C1414034#ent", "<e1>", "R59022", "(", "10(-5)M", ")", "has", "effects", "very", "to", "those", "of", "C0021246#ent", "<e2>", "on", "both", "the", "1,oleoyl-2,acetylglycerol-induced", "and", "the", "A23187-induced", "concentration-response", "curves", "O-2", "generation", "."], "h": {"id": "C1414034", "name": "C1414034#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [14, 15]}}
{"token": ["To", "describe", "the", "effects", "of", "vagus", "nerve", "stimulation", "VNS", ")", "on", "C0393777#ent", "<e1>", "a", "sample", "of", "16", "C0014544#ent", "<e2>", "patients", "."], "h": {"id": "C0393777", "name": "C0393777#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [17, 18]}}
{"token": ["The", "cytoprotective", "effect", "IL-1", "was", "blocked", "by", "indomethacin", "(", "inhibitor", "of", "prostaglandin", "synthesis", "and", "by", "C1416402#ent", "<e1>", "(", "a", "specific", "C1504688#ent", "<e2>", "."], "h": {"id": "C1416402", "name": "C1416402#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1504688", "name": "C1504688#ent", "pos": [20, 21]}}
{"token": ["The", "novel", "interleukin-1", "like", "molecule", "1", "(", "IL-1L1", ")", "which", "has", "greatest", "gene", "sequence", "homology", "with", "C1416402#ent", "<e1>", ",", "the", "gene", "encoding", "C1504688#ent", "<e2>", ",", "is", "another", "potential", "IL-1", "antagonist", "."], "h": {"id": "C1416402", "name": "C1416402#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1504688", "name": "C1504688#ent", "pos": [22, 23]}}
{"token": ["The", "babies", "with", "C0243026#ent", "<e1>", "were", "found", "to", "have", "decreased", "levels", "of", "C1412931#ent", "<e2>", "and", "factor", "B", "compared", "with", "suitably", "matched", "healthy", "controls"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412931", "name": "C1412931#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "the", "occlusion", "of", "the", "pancreatic", "duct", "system", "C0116757#ent", "<e1>", "was", "studied", "in", "cases", "of", "C0030305#ent", "<e2>", "animal", "experiments"], "h": {"id": "C0116757", "name": "C0116757#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [17, 18]}}
{"token": ["Several", "dipeptidases", "such", "as", "glycyl-leucine", ",", "leucyl-glycine", ",", "C0061713#ent", "<e1>", "and", "valyl-proline", "hydrolase", "activities", "were", "lower", "in", "patients", "with", "C0021390#ent", "<e2>", "in", "controls", "."], "h": {"id": "C0061713", "name": "C0061713#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [19, 20]}}
{"token": ["The", "amino-terminal", "fragment", "specifically", "cleaved", "at", "its", "two", "tryptophanyl", "residues", "with", "N-chlorosuccinimide", "and", "the", "central", "cyanogen", "bromide", "fragment", "cleaved", "at", "its", "glutamyl", "residues", "with", "C0143587#ent", "<e1>", "at", "its", "single", "tyrosyl", "residue", "with", "C0038623#ent", "<e2>", "."], "h": {"id": "C0143587", "name": "C0143587#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0038623", "name": "C0038623#ent", "pos": [32, 33]}}
{"token": ["We", "found", "that", "C0011849#ent", "<e1>", "leads", "to", "an", "all-but-total", "stop", "in", "the", "synthesis", "of", "C0119860#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0119860", "name": "C0119860#ent", "pos": [14, 15]}}
{"token": ["Erythrocyte", "acid", "phosphatase", "C0755322#ent", "<e1>", ")", ",", "also", "named", "C1412131#ent", "<e2>", "LMW-PTP", ")", "is", "an", "enzyme", "involved", "in", "signal", "transduction", "pathways", "tyrosine", "kinase", "receptor"], "h": {"id": "C0755322", "name": "C0755322#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412131", "name": "C1412131#ent", "pos": [9, 10]}}
{"token": ["We", "identified", "2", "patients", "who", "presented", "with", "clinical", "features", "consistent", "with", "C2700553#ent", "<e1>", "had", "no", "mutations", "in", "RAG", "or", "C2983312#ent", "<e2>", "."], "h": {"id": "C2700553", "name": "C2700553#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C2983312", "name": "C2983312#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "the", "gene", "encoding", "11-cis-retinol", "dehydrogenase", "C1709800#ent", "<e1>", ";", "EC", ")", "are", "associated", "with", "fundus", "albipunctatus", "an", "C3899988#ent", "<e2>", "by", "stationary", "night", "blindness", "accumulation", "of", "white", "spots", "the", "retina", "."], "h": {"id": "C1709800", "name": "C1709800#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "C1425696#ent", "<e1>", "MCPH3", "locus", "have", "been", "least", "involved", "in", "causing", "C1417075#ent", "<e2>", "phenotype", "."], "h": {"id": "C1425696", "name": "C1425696#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417075", "name": "C1417075#ent", "pos": [12, 13]}}
{"token": ["The", "double-stranded", "trans-DDP-modified", "and", "unmodified", "C0011519#ent", "<e1>", "were", "obtained", "by", "C2975114#ent", "<e2>", "the", "complementary", "strand", "the", "corresponding", "single", "strands", "then", "studied", "by", "31P", "and", "1H", "NMR", "UV", "spectroscopy"], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2975114", "name": "C2975114#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "show", "that", "galectin-3", "binding", "to", "Mgat5-modified", "C0061642#ent", "<e1>", "functions", "together", "with", "pY14Cav1", "to", "stabilize", "C0059239#ent", "<e2>", "FAK", ")", "within", "FAs", ",", "and", "thereby", "promotes", "FA", "disassembly", "and", "turnover", "."], "h": {"id": "C0061642", "name": "C0061642#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [17, 18]}}
{"token": ["A", "treatment", "approach", "proposed", "including", "repeated", "gastric", "lavage", "detection", "of", "an", "insoluble", "tablet", "coagulum", ",", "electrolyte", "monitoring", ",", "avoidance", "of", "C0007422#ent", "<e1>", ",", "and", "treatment", "of", "C0036572#ent", "<e2>", "with", "diazepam", "and", "phenytoin", "."], "h": {"id": "C0007422", "name": "C0007422#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [26, 27]}}
{"token": ["Antigen", "specificity", "investigated", "by", "a", "C1417245#ent", "<e1>", "indirect", "immunofluorescence", "with", "Hep2", "cells", "specific", "for", "antinuclear", "antibodies", "C1412840#ent", "<e2>", ")", "."], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412840", "name": "C1412840#ent", "pos": [16, 17]}}
{"token": ["We", "studied", "the", "expression", "of", "the", "STS", "gene", "primary", "cultures", "cytotrophoblasts", "from", "human", "term", "placentae", "and", "compared", "it", "with", "the", "expression", "of", "autosomally", "encoded", "C1412365#ent", "<e1>", "PALP", ")", "and", "X-linked", "glucose-6-phosphate", "dehydrogenase", "C0017757#ent", "<e2>", ")", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0017757", "name": "C0017757#ent", "pos": [32, 33]}}
{"token": ["Associations", "of", "human", "leukocyte", "antigen", "DR2", "HLA-DR2", ")", "and", "C1881020#ent", "<e1>", "with", "presumed", "C1562543#ent", "<e2>", "POHS", ")", "in", "the", "United", "States", "been", "previously", "described", "."], "h": {"id": "C1881020", "name": "C1881020#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1562543", "name": "C1562543#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "the", "cells", "had", "already", "up-regulated", "CD49d", ",", "asialo", "GM1", ",", "CD11a", ",", "and", "C1539478#ent", "<e1>", ",", "and", "down-regulated", "their", "expression", "of", "C1706237#ent", "<e2>", "."], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706237", "name": "C1706237#ent", "pos": [24, 25]}}
{"token": ["In", "normal", "rats", "and", "monoamine-depleted", "rats", ",", "C0282221#ent", "<e1>", "not", "cause", "locomotor", "hyperactivity", "unlike", "C0813872#ent", "<e2>", "."], "h": {"id": "C0282221", "name": "C0282221#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", "stimulation", "of", "interphase", "cells", "the", "mitogens", "epidermal", "growth", "factor", "lysophosphatidic", "acid", "activates", "the", "C0082529#ent", "<e1>", "ERK", ")", ",", "which", "phosphorylates", "the", "Golgi", "structural", "protein", "C1424530#ent", "<e2>", "at", "serine", "277", "."], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1424530", "name": "C1424530#ent", "pos": [27, 28]}}
{"token": ["Graf", ",", "the", "GTPase", "regulator", "associated", "with", "C1366894#ent", "<e1>", "previously", "shown", "to", "have", "C1419277#ent", "<e2>", "activity", "for", "&", "Rgr", ";", "A", "and", "Cdc42", "in", "vitro", "Hildebrand", "et", "al", "1996", "Mol", "."], "h": {"id": "C1366894", "name": "C1366894#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419277", "name": "C1419277#ent", "pos": [13, 14]}}
{"token": ["Examination", "of", "C0812198#ent", "<e1>", "and", "poly-(ADP", "ribose", ")", "polymerase", "levels", "showed", "no", "change", "in", "C0812198#ent", "<e1>", ",", "but", "decreased", "expression", "of", "poly-(ADP", "ribose)", "polymerase", "C1366618#ent", "<e1>", "induction", "in", "all", "astrocytoma", "cell", "lines"], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366618", "name": "C1366618#ent", "pos": [24, 25]}}
{"token": ["Nordidemnin", "(", "C3472710#ent", "<e1>", ")", ",", "a", "cyclodepsipeptide", "isolated", "from", "marine", "invertebrates", "exhibits", "C1413240#ent", "<e2>", "and", "antitumoral", "properties", "identical", "to", "didemnin", "B", "many", "cell", "lines"], "h": {"id": "C3472710", "name": "C3472710#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [13, 14]}}
{"token": ["We", "report", "that", "significantly", "higher", "production", "of", "type", "2", "cytokines", "and", "augmented", "C1415975#ent", "<e1>", "concentration", "are", "observed", "in", "children", "in", "whom", "HIV", "C1420066#ent", "<e2>", "is", "isolated", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [22, 23]}}
{"token": ["Translational", "inhibitors", "alpha-sarcin", ",", "ricin", "and", "auto-immune", "antibodies", "C2984553#ent", "<e1>", "inhibit", "binding", "of", "C0059037#ent", "<e2>", "but", "not", "of", "EF-3", "to", "yeast", "ribosomes"], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [13, 14]}}
{"token": ["To", "examine", "the", "treatment", "efficacy", "of", "C1119918#ent", "<e1>", "KRG", ")", "in", "C0242350#ent", "<e2>", "men", "with", "erectile", "dysfunction", "ED", ")", "."], "h": {"id": "C1119918", "name": "C1119918#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0242350", "name": "C0242350#ent", "pos": [11, 12]}}
{"token": ["This", "is", "the", "first", "report", "of", "a", "STK11", "germline", "mutation", "a", "C0694883#ent", "<e1>", "patient", "with", "C1367452#ent", "<e2>", "and", "should", "contribute", "to", "establishing", "correlations", "between", "the", "STK11", "germline", "mutations", "C1367452#ent", "<e2>", "in", "C0694883#ent", "<e1>", "patients", "."], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [15, 16]}}
{"token": ["This", "is", "the", "first", "report", "of", "a", "C0694883#ent", "<e1>", "germline", "mutation", "a", "PJS", "patient", "with", "C1367452#ent", "<e2>", "and", "should", "contribute", "to", "establishing", "correlations", "between", "the", "C0694883#ent", "<e1>", "germline", "mutations", "C1367452#ent", "<e2>", "in", "PJS", "patients", "."], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [15, 16]}}
{"token": ["No", "inactivation", "of", "the", "wild-type", "allele", "by", "somatic", "mutation", "or", "chromosomal", "deletion", "hypermethylation", "at", "the", "5'-CpG", "site", "of", "C0694883#ent", "<e1>", "was", "detected", "in", "the", "C1367452#ent", "<e2>", "."], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [24, 25]}}
{"token": ["C0056650#ent", "<e1>", "also", "ameliorated", "C0812246#ent", "<e2>", "decrease", "of", "Trx", "S-nitrosylation", "and", "intracellular", "glutathione", "and", "elevation", "of", "4-hydroxynonenal", "(", "4-HNE", ")", ",", "a", "major", "aldehydic", "product", "lipid", "peroxidation"], "h": {"id": "C0056650", "name": "C0056650#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [4, 5]}}
{"token": ["There", "was", "activation", "of", "the", "fibrinolytic", "pathway", "shown", "by", "reduction", "of", "C1367553#ent", "<e1>", "with", "high", "C0618743#ent", "<e2>", "and", "low", "kallikrein", "values", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [15, 16]}}
{"token": ["Interestingly", ",", "it", "was", "shown", "that", "human", "kallikrein", "13", "similarly", "to", "PSA", ",", "could", "specifically", "cleave", "human", "C1367553#ent", "<e1>", "to", "generate", "angiostatin-like", "fragments", ",", "suggesting", "that", "specific", "C0618743#ent", "<e2>", "may", "have", "antiangiogenic", "actions"], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [27, 28]}}
{"token": ["A", "dopamine", "(", "DA", ")", "antagonist", ",", "metoclopramide", ",", "stimulates", "C1704793#ent", "<e1>", "secretion", "in", "some", "women", "with", "C0341862#ent", "<e2>", "HA", ")", "but", "not", "in", "normal", "women", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0341862", "name": "C0341862#ent", "pos": [17, 18]}}
{"token": ["How", "this", "C0536221#ent", "<e1>", "its", "close", "relative", "C2681848#ent", "<e2>", "regulate", "cellular", "behaviour", "still", "very", "much", "an", "open", "question", "."], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2681848", "name": "C2681848#ent", "pos": [7, 8]}}
{"token": ["The", "etiologic", "bacteria", "were", "eradicated", "except", "Salmonella", "sp.", "Side", "effects", "observed", "in", "3.5", "%", "cases", ";", "one", "was", "diarrhea", "and", "C0343874#ent", "<e1>", "one", "was", "C2129214#ent", "<e2>", "and", "one", "was", "C0343874#ent", "<e1>"], "h": {"id": "C0343874", "name": "C0343874#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2129214", "name": "C2129214#ent", "pos": [24, 25]}}
{"token": ["To", "explore", "the", "effects", "of", "Capsules", "(", "ZXKC", ")", "and", "C0033215#ent", "<e1>", "on", "blood", "lipids", "vascular", "endothelial", "functions", "redox", "status", "patients", "with", "C1956346#ent", "<e2>"], "h": {"id": "C0033215", "name": "C0033215#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [22, 23]}}
{"token": ["C0001492#ent", "<e1>", "inhibited", "by", "C1825938#ent", "<e2>", "and", "Gi-3", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1825938", "name": "C1825938#ent", "pos": [4, 5]}}
{"token": ["Pertussis", "toxin", "pretreatment", "of", "the", "Jurkat", "cells", "caused", "an", "ADP", "ribosylation", "of", "two", "G-proteins", "that", "inhibit", "C0001492#ent", "<e1>", "tentatively", "identified", "as", "C1825938#ent", "<e2>", "and", "Gi3", ",", "using", "Western", "blots"], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1825938", "name": "C1825938#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "the", "murine", "LH", "receptor", "C0001492#ent", "<e1>", "Gs", "and", "PLC", "via", "selective", "coupling", "to", "C1825938#ent", "<e2>", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1825938", "name": "C1825938#ent", "pos": [15, 16]}}
{"token": ["C0025872#ent", "<e1>", "is", "currently", "approved", "for", "use", "against", "Trichomonas", "infection", "C0002438#ent", "<e2>", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002438", "name": "C0002438#ent", "pos": [10, 11]}}
{"token": ["C0025872#ent", "<e1>", "is", "a", "drug", "used", "for", "the", "treatment", "of", "trichomonal", "vaginitis", "C0002438#ent", "<e2>", ",", "giardiasis", ",", "and", "certain", "anaerobic", "bacterial", "infections", "humans", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0002438", "name": "C0002438#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "C1704947#ent", "<e1>", "on", "the", "growth", ",", "and", "APase", "and", "C3273601#ent", "<e2>", "activities", "of", "Pi-starved", "B.", "napus", "seedlings", "were", "similar", "to", "those", "observed", "in", "the", "suspension", "cells"], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273601", "name": "C3273601#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "luteolin", "induced", "S-phase", "cell", "cycle", "arrest", "increased", "the", "mRNA", "of", "C1333237#ent", "<e1>", "enzymes", "such", "as", "human", "MutT", "homologue", "C1313359#ent", "<e2>", "and", "apurinic", "endonuclease"], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1313359", "name": "C1313359#ent", "pos": [22, 23]}}
{"token": ["We", "assessed", "the", "association", "between", "polymorphisms", "in", "two", "genes", "involved", "in", "C1333237#ent", "<e1>", "oxidative", "stress", "GPX", "and", "C1313359#ent", "<e2>", ",", "and", "risk", "of", "colorectal", "carcinoma", "adenomas", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1313359", "name": "C1313359#ent", "pos": [17, 18]}}
{"token": ["An", "increase", "in", "intracellular", "cAMP", "upon", "stimulation", "with", "caffeine", "increases", "C1842325#ent", "<e1>", "expression", "while", "activation", "of", "C1259877#ent", "<e2>", "PKC", ")", "with", "phorbol", "myristate", "acetate", "PMA", ")", "results", "in", "decreased", "C1842325#ent", "<e1>", "expression", "."], "h": {"id": "C1842325", "name": "C1842325#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [16, 17]}}
{"token": ["However", ",", "ET-1-", "and", "KCl-induced", "increase", "of", "[Ca2+]i", "was", "not", "diminished", "by", "other", "drugs", "including", "brimonidine", ",", "dipivefrin", ",", "brinzolamide", ",", "dorzolamide", ",", "C0090306#ent", "<e1>", ",", "pilocarpine", ",", "and", "C0005026#ent", "<e2>"], "h": {"id": "C0090306", "name": "C0090306#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0005026", "name": "C0005026#ent", "pos": [29, 30]}}
{"token": ["Studies", "suggested", "that", "the", "viral", ",", "especially", "C0149678#ent", "<e1>", "and", "bacterial", "infections", "especially", "C0024198#ent", "<e2>", "play", "a", "role", "in", "etiology", "of", "MS", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024198", "name": "C0024198#ent", "pos": [13, 14]}}
{"token": ["LPS-induced", "C1705527#ent", "<e1>", "levels", "were", "diminished", "in", "animals", "pretreated", "with", "C0287041#ent", "<e2>", "and", "in", "those", "deficient", "for", "the", "ATII", "receptor", "1a", "."], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [10, 11]}}
{"token": ["By", "three", "criteria", "--", "tunicamycin", "inhibition", ",", "lectin", "binding", "metabolic", "labeling", "with", "radioactive", "sugar", "precursors", "--", "the", "product", "of", "the", "C0069528#ent", "<e1>", "to", "be", "a", "C0072522#ent", "<e2>", "."], "h": {"id": "C0069528", "name": "C0069528#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [25, 26]}}
{"token": ["The", "Ad5", "DNA", "sequence", "the", "same", "C1412821#ent", "<e1>", "that", "of", "C1863051#ent", "<e2>", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1863051", "name": "C1863051#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "in", "contrast", "to", "the", "wild", "type", "mutant", "strain", "C3273610#ent", "<e1>", "Prp", "constitutively", "produces", "a", "small", "amount", "of", "monooxygenase", "and", "C0054859#ent", "<e2>", "."], "h": {"id": "C3273610", "name": "C3273610#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0054859", "name": "C0054859#ent", "pos": [21, 22]}}
{"token": ["Finally", ",", "a", "possible", "sarcoma-associated", "alteration", "in", "the", "structure", "of", "C0069919#ent", "<e1>", "has", "been", "noted", "in", "the", "ml", "clone", "of", "C0026574#ent", "<e2>"], "h": {"id": "C0069919", "name": "C0069919#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026574", "name": "C0026574#ent", "pos": [20, 21]}}
{"token": ["Following", "challenge", ",", "pigs", "that", "were", "immunized", "with", "C0069076#ent", "<e1>", "showed", "more", "severe", "C0037090#ent", "<e2>", "had", "a", "higher", "mortality", "rate", "died", "faster", "."], "h": {"id": "C0069076", "name": "C0069076#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037090", "name": "C0037090#ent", "pos": [13, 14]}}
{"token": ["Generally", ",", "it", "was", "observed", "that", "severe", "purulent", "ureteritis", "C0034186#ent", "<e1>", "sows", "were", "to", "be", "expected", "only", "in", "C0275524#ent", "<e2>", "A.", "suis", "with", "other", "bacteria", "."], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [18, 19]}}
{"token": ["Oxidative", "stress", "thought", "to", "be", "the", "pathogenesis", "of", "C0034069#ent", "<e1>", "induced", "by", "C0003949#ent", "<e2>", ",", "and", "heme", "oxygenase-1", "HO-1", ")", "protects", "lung", "tissue", "oxidative", "stress"], "h": {"id": "C0034069", "name": "C0034069#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003949", "name": "C0003949#ent", "pos": [12, 13]}}
{"token": ["The", "results", "from", "the", "present", "study", "do", "not", "provide", "evidence", "for", "increased", "placental", "tNOS", "or", "C1417760#ent", "<e1>", "activities", "in", "pregnancies", "complicated", "by", "C0085207#ent", "<e2>", "diabetes", "present", "before", "pregnancy", "."], "h": {"id": "C1417760", "name": "C1417760#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [22, 23]}}
{"token": ["These", "effects", "were", "completely", "abolished", "by", "SB203580", "and", "SB202190", "(", "p38", "MAPK", "inhibitors", "but", "not", "by", "PD98059", "(", "MEK1", "inhibitor", ")", ",", "C0054537#ent", "<e1>", "protein", "kinase", "C", "inhibitor", ",", "or", "genistein", "(", "C1268567#ent", "<e2>", "."], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [32, 33]}}
{"token": ["The", "protein", "kinase", "C", "inhibitors", "staurosporine", "and", "C0054537#ent", "<e1>", "and", "the", "C1268567#ent", "<e2>", "genistein", ",", "but", "not", "its", "inactive", "analogue", "daidzein", ",", "prevented", "the", "induction", "of", "CYP2E1", "by", "PDBu", "."], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [11, 12]}}
{"token": ["Consistently", ",", "1l", "dowregulated", "endothelial", "nitric", "oxide", "synthase", "MAPK-extracellular", "receptor", "kinase", "1", "-", "2", "(", "C1366765#ent", "<e1>", "-", "2", ")", "activity", "and", "C0623362#ent", "<e2>", "MMP-2/MMP-9", ")", ",", "while", "the", "tissue", "inhibitors", "metalloproteinases", "(", "TIMP2/TIMP-1", ")", "were", "upregulated", "."], "h": {"id": "C1366765", "name": "C1366765#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [22, 23]}}
{"token": ["The", "cells", "were", "incubated", "with", "group", "IA", "IB", ",", "IIA", "and", "III", "C1418616#ent", "<e1>", "and", "the", "release", "of", "C0812246#ent", "<e2>", ",", "IL-6", "and", "IL-12", "was", "determined", "by", "ELISA", "."], "h": {"id": "C1418616", "name": "C1418616#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [18, 19]}}
{"token": ["Contrary", "to", "caspase", "inhibitors", "a", "panel", "of", "pharmacological", "cathepsin", "B", "inhibitors", ",", "the", "endogenous", "C0916743#ent", "<e1>", "cystatin", "A", "well", "as", "antisense-mediated", "depletion", "of", "C0699919#ent", "<e2>", "WEHI-S", "cells", "from", "apoptosis", "triggered", "by", "TNF", "or", "TNF-related", "apoptosis-inducing", "ligand"], "h": {"id": "C0916743", "name": "C0916743#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [23, 24]}}
{"token": ["Using", "immunohistology", ",", "the", "C0916743#ent", "<e1>", "detected", "co-expressed", "with", "C0699919#ent", "<e2>", "lung", "and", "bone", "metastases", "both", "the", "murine", "model", "and", "human", "tissues", "."], "h": {"id": "C0916743", "name": "C0916743#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [9, 10]}}
{"token": ["A", "Staphylococcus", "aureus", "with", "low-level", "heteroresistance", "to", "vancomycin", "(", "designated", "MER", ")", "but", "susceptible", "to", "methicillin", "was", "isolated", "from", "an", "outpatient", "with", "C0009774#ent", "<e1>", "who", "did", "not", "receive", "any", "C0017953#ent", "<e2>"], "h": {"id": "C0009774", "name": "C0009774#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0017953", "name": "C0017953#ent", "pos": [29, 30]}}
{"token": ["For", "the", "patient", "with", "migraine", "and", "C0014544#ent", "<e1>", ",", "or", "migraine", "and", "manic", "depressive", "illness", "C0886883#ent", "<e2>", "the", "drug", "of", "choice", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0886883", "name": "C0886883#ent", "pos": [15, 16]}}
{"token": ["Calpain", ",", "a", "C0006784#ent", "<e1>", "was", "activated", "in", "stimulated", "type", "II", "cells", "cleaved", "purified", "C1412417#ent", "<e2>", "the", "N-terminus", "minus", "26", "amino", "acids"], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412417", "name": "C1412417#ent", "pos": [14, 15]}}
{"token": ["Western", "blot", "analysis", "that", "treatment", "with", "10(-5", ")", "mol/liter", "C0209366#ent", "<e1>", "significantly", "(", "P", "<", "0.01", ")", "decreased", "C1366837#ent", "<e2>", "expression", "."], "h": {"id": "C0209366", "name": "C0209366#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [18, 19]}}
{"token": ["The", "central", "C0067685#ent", "<e1>", "deficit", "model", "of", "schizophrenia", "could", "explain", "the", "C0027721#ent", "<e2>", "from", "the", "perspectives", "of", "both", "neurodevelopment", "and", "neurodegeneration", ",", "and", "may", "point", "to", "potential", "treatments", "for", "schizophrenia", "."], "h": {"id": "C0067685", "name": "C0067685#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [11, 12]}}
{"token": ["In", "a", "Slovene", "patient", "with", "C0002453#ent", "<e1>", "an", "association", "with", "blepharophimosis/ptosis/epicanthus", "inversus", "syndrome", "C0220663#ent", "<e2>", ")", ",", "a", "novel", "30", "bp", "deletion", "was", "identified", "in", "the", "FOXL2", "gene"], "h": {"id": "C0002453", "name": "C0002453#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0220663", "name": "C0220663#ent", "pos": [13, 14]}}
{"token": ["The", "radio-TLC", "separation", "of", "the", "reaction", "metabolites", "a", "dose", "dependent", "inhibition", "of", "the", "C0389003#ent", "<e1>", "and", "the", "5-lipoxygenase", "activity", "the", "fat", "soluble", "C0770737#ent", "<e2>", "fraction", "."], "h": {"id": "C0389003", "name": "C0389003#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0770737", "name": "C0770737#ent", "pos": [22, 23]}}
{"token": ["Inhibitory", "NANC", "nerves", "the", "only", "bronchodilator", "pathway", "in", "human", "airways", ",", "and", "there", "is", "some", "evidence", "that", "the", "C0243051#ent", "<e1>", "is", "predominantly", "nitric", "oxide", "although", "C1366646#ent", "<e2>", "be", "contributory", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1366646", "name": "C1366646#ent", "pos": [25, 26]}}
{"token": ["Such", "DNA", "preparations", "found", "to", "be", "quite", "suitable", "for", "digestion", "by", "a", "variety", "of", "C0012906#ent", "<e1>", "as", "well", "as", "for", "the", "analysis", "of", "C0019247#ent", "<e2>", "different", "biological", "methods"], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [23, 24]}}
{"token": ["Infections", "included", "invasive", "pulmonary", "aspergillosis", "C0019348#ent", "<e1>", "esophagitis", ",", "cytomegalovirus", "pneumonia", "bacterial", "sepsis", "fungemia", "and", "C0025289#ent", "<e2>", "due", "to", "Cryptococcus", "neoformans"], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [15, 16]}}
{"token": ["The", "kinetic", "properties", "of", "a", "microsomal", "gill", "(", "Na(+),K(+))-ATPase", "from", "the", "C3496090#ent", "<e1>", "Callinectes", "danae", "analyzed", "using", "the", "C0028189#ent", "<e2>"], "h": {"id": "C3496090", "name": "C3496090#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0028189", "name": "C0028189#ent", "pos": [18, 19]}}
{"token": ["In", "this", "system", ",", "the", "C0005220#ent", "<e1>", "been", "transformed", "into", "an", "C1336632#ent", "<e2>", "substrate", "by", "insertion", "of", "the", "p6/PR", "cleavage", "site", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336632", "name": "C1336632#ent", "pos": [11, 12]}}
{"token": ["However", ",", "antibodies", "in", "the", "serum", "of", "three", "Lyme", "arthritis", "patients", ",", "which", "were", "reactive", "with", "C0037974#ent", "<e1>", "HSP70", ",", "did", "not", "cross-react", "with", "human", "C1527149#ent", "<e2>"], "h": {"id": "C0037974", "name": "C0037974#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [25, 26]}}
{"token": ["C0027679#ent", "<e1>", "is", "at", "present", "the", "mainstay", "in", "treatment", "of", "C0026896#ent", "<e2>"], "h": {"id": "C0027679", "name": "C0027679#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [10, 11]}}
{"token": ["This", "case", "confirms", "that", "C0022350#ent", "<e1>", "a", "cause", "of", "neonatal", "C0008370#ent", "<e2>", "."], "h": {"id": "C0022350", "name": "C0022350#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0008370", "name": "C0008370#ent", "pos": [10, 11]}}
{"token": ["Diurnal", "changes", "in", "irradiance", "did", "not", "alter", "C0085292#ent", "<e1>", "transcript", "levels", ",", "indicating", "that", "short-term", "regulation", "of", "C4255078#ent", "<e2>", "primarily", "involves", "a", "modulation", "of", "enzyme", "activity"], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4255078", "name": "C4255078#ent", "pos": [17, 18]}}
{"token": ["Monocrotaline", "and", "C0074322#ent", "<e1>", "shown", "in", "behavioral", "assays", "be", "C0304402#ent", "<e2>", "."], "h": {"id": "C0074322", "name": "C0074322#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [9, 10]}}
{"token": ["In", "the", "present", "study", ",", "the", "ribosomal", "assembly", "beta-globin", "chains", "examined", "in", "the", "peripheral", ",", "nucleated", "red", "blood", "cells", "reticulocytes", "of", "patients", "with", "Cooley's", "anemia", "thalassemia", "intermedia", "sickle", "thalassemia", "sickle", "cell", "anemia", "C0019021#ent", "<e1>", "and", "in", "hemolytic", "anemias", "associated", "with", "C0019045#ent", "<e2>", "."], "h": {"id": "C0019021", "name": "C0019021#ent", "pos": [32, 33]}, "relation": "has_nichd_parent", "t": {"id": "C0019045", "name": "C0019045#ent", "pos": [40, 41]}}
{"token": ["We", "reviewed", "the", "clinical", "course", "physical", "findings", "and", "hematologic", "values", "16", "pediatric", "patients", "with", "C0019021#ent", "<e1>", "all", "but", "one", "identified", "by", "a", "C0019045#ent", "<e2>", "screening", "program"], "h": {"id": "C0019021", "name": "C0019021#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0019045", "name": "C0019045#ent", "pos": [22, 23]}}
{"token": ["Positively", "selecting", "cortical", "thymic", "epithelial", "cells", "C3272493#ent", "<e1>", ")", "expressed", "only", "housekeeping", "but", "no", "C1419015#ent", "<e2>", "mRNA", "and", "proteins", "."], "h": {"id": "C3272493", "name": "C3272493#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419015", "name": "C1419015#ent", "pos": [14, 15]}}
{"token": ["Immunotactoid", "glomerulopathy", "characterized", "by", "the", "ultrastructural", "finding", "fibrillary", "or", "microtubular", "deposits", "in", "patients", "without", "systemic", "diseases", "as", "C0014060#ent", "<e1>", ",", "diabetes", ",", "paraproteinemias", ",", "cryoglobulinemia", ",", "or", "C0002726#ent", "<e2>", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [27, 28]}}
{"token": ["Molecular", "cloning", "the", "responsible", "C0079429#ent", "<e1>", "on", "chromosome", "6q25.2", "-", "27", "for", "autosomal", "recessive", "juvenile", "parkinsonism", "C2983548#ent", "<e2>", ")", "identified", "a", "novel", "protein", "of", "unknown", "function", ",", "named", "parkin", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2983548", "name": "C2983548#ent", "pos": [16, 17]}}
{"token": ["Eukaryotic", "genomes", "encode", "ligases", "requiring", "C1705556#ent", "<e1>", "as", "the", "cofactor", ";", "C0085238#ent", "<e2>", "encode", "NAD(+)-dependent", "ligase", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085238", "name": "C0085238#ent", "pos": [11, 12]}}
{"token": ["We", "discuss", "how", "our", "results", "for", "C1416647#ent", "<e1>", "and", "parallel", "studies", "KIR2DS2", "relate", "to", "the", "association", "between", "activating", "C1415041#ent", "<e2>", "genes", "and", "susceptibility", "to", "autoimmune", "disorders"], "h": {"id": "C1416647", "name": "C1416647#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415041", "name": "C1415041#ent", "pos": [18, 19]}}
{"token": ["Our", "results", "suggest", "that", "the", "intermediate", "band", "due", "to", "a", "modified", "precursor", "of", "C0052898#ent", "<e1>", "with", "a", "truncated", "presequence", "of", "about", "eight", "C3539946#ent", "<e2>"], "h": {"id": "C0052898", "name": "C0052898#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [22, 23]}}
{"token": ["The", "C1333903#ent", "<e1>", "as", "architectural", "transcription", "factors", "are", "involved", "in", "the", "regulation", "of", "C0017337#ent", "<e2>", "important", "in", "the", "process", "of", "carcinogenesis", "."], "h": {"id": "C1333903", "name": "C1333903#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["Depletion", "of", "Leu-11b-positive", "cells", "from", "the", "NT", ",", "C1826435#ent", "<e1>", "exposed", "to", "IFN-alpha", "C1418754#ent", "<e2>", "restored", "the", "autologous", "T", "cell", "response", "."], "h": {"id": "C1826435", "name": "C1826435#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418754", "name": "C1418754#ent", "pos": [13, 14]}}
{"token": ["Among", "the", "several", "C0014442#ent", "<e1>", "activities", "in", "rabbit", "liver", "cytosol", "to", "C1721278#ent", "<e2>", "only", "the", "main", "activity", "was", "not", "separable", "from", "3-hydroxyhexobarbital", "dehydrogenase", "purification", "including", "polyacrylamide", "gel", "disc", "electrophoresis"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1721278", "name": "C1721278#ent", "pos": [11, 12]}}
{"token": ["Men", "with", "painful", "C0018418#ent", "<e1>", "were", "given", "10", "mg", "of", "C0039286#ent", "<e2>", "for", "3", "months", "."], "h": {"id": "C0018418", "name": "C0018418#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "anti-inflammatory", "drugs", "diclofenac", ",", "piroxicam", ",", "indomethacin", ",", "C0027396#ent", "<e1>", ",", "nabumetone", ",", "nimesulide", ",", "and", "meloxicam", "on", "mitochondrial", "respiration", "C2744579#ent", "<e2>", "synthesis", ",", "and", "membrane", "potential", "determined", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [23, 24]}}
{"token": ["Most", "C0017495#ent", "<e1>", "patients", "also", "show", "C0023530#ent", "<e2>", "and", "neutrophil", "dysfunction", "therefore", "are", "at", "risk", "of", "developing", "severe", "infections", "and", "inflammatory", "bowel", "disease", "IBD", ")", "."], "h": {"id": "C0017495", "name": "C0017495#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [6, 7]}}
{"token": ["Two", "out", "of", "five", "patients", "with", "C0264863#ent", "<e1>", "two", "patients", "with", "C0403414#ent", "<e2>", "large", "amounts", "of", "soluble", "circulating", "immune", "complexes", "their", "sera", "."], "h": {"id": "C0264863", "name": "C0264863#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0403414", "name": "C0403414#ent", "pos": [11, 12]}}
{"token": ["A", "neuroprotective", "role", "C2348308#ent", "<e1>", ",", "possibly", "in", "association", "with", "the", "C0078264#ent", "<e2>", "VE", ")", "linkage", "of", "plasmalogens", "(", "pPLs", ")", "in", "combating", "free", "radicals", "proposed", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0078264", "name": "C0078264#ent", "pos": [11, 12]}}
{"token": ["The", "reliability", "of", "the", "method", "was", "established", "by", "measuring", "variations", "of", "c-Ki-Ras", ",", "ornithine", "decarboxylase", "alpha-amylase", ",", "and", "C1384510#ent", "<e1>", "mRNA", "levels", "during", "the", "growth", "of", "pancreatic", "tumoral", "C3540804#ent", "<e2>", "-", "2J", "cells", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3540804", "name": "C3540804#ent", "pos": [28, 29]}}
{"token": ["Wild-type", "alleles", "upregulation", "of", "CDR1", "and", "C3538867#ent", "<e1>", "upon", "exposure", "to", "inducers", "such", "as", "C0016368#ent", "<e2>", ",", "while", "hyperactive", "alleles", "result", "in", "constitutive", "high", "expression", "of", "CDR1", "and", "C3538867#ent", "<e1>", "."], "h": {"id": "C3538867", "name": "C3538867#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [14, 15]}}
{"token": ["Particularly", "important", "are", "the", "associations", "of", "pemphigoid", "and", "C0038013#ent", "<e1>", "RA", ")", "and", "C1832586#ent", "<e2>", "and", "thyroid", "disorders"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1832586", "name": "C1832586#ent", "pos": [13, 14]}}
{"token": ["LARGE", "is", "a", "putative", "glycosyltransferase", "to", "be", "mutated", "in", "mice", "with", "C0013264#ent", "<e1>", "or", "patients", "with", "C0699743#ent", "<e2>"], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0699743", "name": "C0699743#ent", "pos": [16, 17]}}
{"token": ["The", "study", "showed", "that", "compared", "with", "placebo", "both", "loratadine", "and", "C0546858#ent", "<e1>", "were", "effective", "in", "relieving", "nasal", "and", "eye", "symptoms", "patients", "with", "C0035457#ent", "<e2>"], "h": {"id": "C0546858", "name": "C0546858#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [22, 23]}}
{"token": ["The", "microdeletion", "of", "C0012236#ent", "<e1>", "the", "most", "common", "human", "C0795796#ent", "<e2>"], "h": {"id": "C0012236", "name": "C0012236#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0795796", "name": "C0795796#ent", "pos": [9, 10]}}
{"token": ["[alpha-(32)P]azidoADP.Vi", "trapping", "was", "also", "decreased", "by", "estone", "sulfate", "whereas", "C0042679#ent", "<e1>", ",", "verapamil", ",", "and", "C0912024#ent", "<e2>", "had", "no", "apparent", "effects", "on", "nucleotide", "interactions", "MRP1", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0912024", "name": "C0912024#ent", "pos": [15, 16]}}
{"token": ["Genetic", "analysis", "that", "he", "had", "C0162283#ent", "<e1>", "by", "a", "novel", "mutation", "(", "deletion", "of", "6", "C3539947#ent", "<e2>", "G107", "and", "C112", ")", "in", "the", "vasopressin", "V2", "receptor", "gene"], "h": {"id": "C0162283", "name": "C0162283#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [15, 16]}}
{"token": ["Companion", "C0040975#ent", "<e1>", "examinations", "revealed", "large", "depots", "of", "glycogen", "within", "C0669372#ent", "<e2>", "."], "h": {"id": "C0040975", "name": "C0040975#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}}
{"token": ["Pigs", "C0342895#ent", "<e1>", "the", "coarse", "diets", "increased", "concentration", "of", "C1161319#ent", "<e2>", "the", "cecum", "(", "P", "<", "0.05", ")", "and", "colon", "(", "P", "<", "0.10", ")", "compared", "with", "pigs", "C0342895#ent", "<e1>", "the", "fine", "diets"], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1161319", "name": "C1161319#ent", "pos": [9, 10]}}
{"token": ["Then", ",", "determining", "their", "plasma", "endothelin", "and", "calcitonin", "gene-related", "peptide", "C1335796#ent", "<e1>", ")", "with", "radioimmunoassay", "(", "RIA", ")", "and", "observing", "the", "effects", "of", "on", "plasma", "endothelin", "C1335796#ent", "<e1>", "in", "quail", "C0004153#ent", "<e1>", "models", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [30, 31]}}
{"token": ["Here", "we", "identify", "C3539652#ent", "<e1>", ",", "a", "glutamine-rich", "protein", "forms", "a", "ternary", "complex", "with", "the", "C0812382#ent", "<e2>", "the", "receptor", "'s", "intracellular", "domain", "."], "h": {"id": "C3539652", "name": "C3539652#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [15, 16]}}
{"token": ["She", "was", "treated", "unsuccessfully", "using", "human", "FVIII", "and", "cryoprecipitate", ",", "porcine", "FVIII", "and", "C1705338#ent", "<e1>", "complex", "concentrate", ",", "before", "being", "treated", "with", "recombinant", "FVIIa", "(", "C0593103#ent", "<e2>", ",", "Novo", "Nordisk", "."], "h": {"id": "C1705338", "name": "C1705338#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0593103", "name": "C0593103#ent", "pos": [25, 26]}}
{"token": ["Only", "in", "the", "liver", "did", "C0008370#ent", "<e1>", "decrease", "the", "C0051169#ent", "<e2>", "content", "and", "the", "peroxisomal", "fatty", "acid", "beta-oxidation", "the", "catalase", "activity", "and", "the", "microsomal", "metabolism", "lauric", "acid", "aminopyrine", "."], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [9, 10]}}
{"token": ["C0004259#ent", "<e1>", "used", "in", "modified", "ECT", "is", "known", "to", "increase", "C2699120#ent", "<e2>", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2699120", "name": "C2699120#ent", "pos": [10, 11]}}
{"token": ["C1520007#ent", "<e1>", "expressed", "p12(I", ")", "in", "Jurkat", "T", "cells", "interleukin-2", "(", "C1522405#ent", "<e2>", ")", "production", "in", "a", "calcium", "pathway-dependent", "manner", "during", "T-cell", "receptor", "TCR", ")", "stimulation", "."], "h": {"id": "C1520007", "name": "C1520007#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [11, 12]}}
{"token": ["The", "tubulins", "and", "other", "atypical", "C0018296#ent", "<e1>", "thus", "appear", "to", "represent", "convergent", "solutions", "to", "the", "C1528775#ent", "<e2>", "and", "hydrolysis", "problem", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528775", "name": "C1528775#ent", "pos": [15, 16]}}
{"token": ["Grn1p", "from", "fission", "yeast", "GNL3L", "from", "human", "cells", "two", "putative", "C0018296#ent", "<e1>", "from", "the", "novel", "HSR1_MMR1", "C1528775#ent", "<e2>", "circularly", "permuted", "G-motifs", "play", "a", "critical", "role", "in", "maintaining", "normal", "cell", "growth"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528775", "name": "C1528775#ent", "pos": [16, 17]}}
{"token": ["The", "cytokine", "hormones", "C1418938#ent", "<e1>", "and", "erythropoietin", "mediate", "tissue-specific", "developmental", "outcomes", "activating", "their", "cognate", "receptors", "C1335265#ent", "<e2>", "PrlR", ")", "and", "erythropoietin", "receptor", "EpoR", ")", ",", "respectively", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335265", "name": "C1335265#ent", "pos": [15, 16]}}
{"token": ["The", "dissociated", "hormone", "was", "characterized", "as", "intact", "C1418938#ent", "<e1>", "Bio-Gel", "P-150", "gel", "chromatography", "by", "its", "ability", "to", "bind", "to", "fresh", "rabbit", "C1335265#ent", "<e2>", "the", "same", "binding", "affinity", "as", "native", "hormone", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335265", "name": "C1335265#ent", "pos": [21, 22]}}
{"token": ["To", "evaluate", "the", "long", "term", "efficacy", "of", "treatment", "with", "intravenous", "iloprost", "severe", "C0151445#ent", "<e1>", "RP", ")", "and", "ischemic", "leg", "ulcers", "patients", "with", "C0004364#ent", "<e2>"], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [22, 23]}}
{"token": ["YM461", "inhibited", "C0235480#ent", "<e1>", "induced", "rabbit", "and", "human", "platelet", "aggregation", "C1839576#ent", "<e2>", "values", "of", "7.52", "and", "7.29", ",", "respectively", ";", "the", "slopes", "of", "the", "Schild", "plots", "were", "1.07", "and", "1.01", ",", "respectively", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [10, 11]}}
{"token": ["Pharmacoeconomic", "data", "a", "small", "study", "of", "patients", "with", "C0036572#ent", "<e1>", "a", "US", "emergency", "department", "an", "overall", "cost", "advantage", "of", "C0284906#ent", "<e2>", "over", "phenytoin", ",", "despite", "a", "considerably", "greater", "acquisition", "cost", "of", "C0284906#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}, "relation": "may_be_prevented_by", "t": {"id": "C0284906", "name": "C0284906#ent", "pos": [19, 20]}}
{"token": ["Two", "major", "C0022173#ent", "<e1>", "are", "known-", "micro", "-calpain", "(", "C1413109#ent", "<e2>", ")", "and", "m-calpain", "(CAPN2)-requiring", "micromolar", "and", "millimolar", "calcium", "concentrations", "activation", ",", "respectively", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413109", "name": "C1413109#ent", "pos": [9, 10]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "if", "a", "C2927148#ent", "<e1>", "selectively", "decrease", "consumption", "of", "highly", "palatable", "food", "in", "C1334982#ent", "<e2>", "primates", "."], "h": {"id": "C2927148", "name": "C2927148#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334982", "name": "C1334982#ent", "pos": [20, 21]}}
{"token": ["C0206368#ent", "<e1>", "20", "-", "1", "is", "one", "of", "several", "hundred", "C1418630#ent", "<e2>", "zinc", "finger", "proteins", "of", "unknown", "biological", "function", "Xenopus", "."], "h": {"id": "C0206368", "name": "C0206368#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418630", "name": "C1418630#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "it", "has", "been", "clarified", "that", "C1334119#ent", "<e1>", "plays", "an", "important", "role", "in", "the", "regulation", "of", "estrogen", "synthesis", "C3541394#ent", "<e2>", "including", "17beta-HSD", "and", "3beta-HSD", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [20, 21]}}
{"token": ["Five", "chemokine", "receptor", "genes", "CCR1", ",", "CCR3", ",", "CCR2", ",", "CCR5", ",", "and", "C1332701#ent", "<e1>", ")", "were", "localized", "in", "C1413346#ent", "<e2>", "in", "a", "225-kb", "cluster", "."], "h": {"id": "C1332701", "name": "C1332701#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413346", "name": "C1413346#ent", "pos": [19, 20]}}
{"token": ["C0007332#ent", "<e1>", "and", "regular", "whey", "increased", "hardness", ",", "but", "WPH-I", "and", "C3273406#ent", "<e2>", "substantially", "reduced", "hardness", ",", "fracturability", "and", "springiness", "."], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [11, 12]}}
{"token": ["C0045376#ent", "<e1>", ">", "C0017789#ent", "<e2>", "was", "established", "(", "where", "C0045376#ent", "<e1>", "is", "2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo", "(", "f", ")", "quinoxaline", ")", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0045376", "name": "C0045376#ent", "pos": [0, 1]}}
{"token": ["Anaesthesia", "was", "induced", "with", "C0936073#ent", "<e1>", "and", "suxamethonium", "and", "maintained", "with", "atracurium", ",", "nitrous", "oxide", "C0022180#ent", "<e2>", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [15, 16]}}
{"token": ["C0064450#ent", "<e1>", "kynurenine", "3-hydroxylase", "and", "3-hydroxyanthranilic", "acid", "dioxygenase", "to", "be", "C0669365#ent", "<e2>", "expressed", "in", "both", "cell", "lines"], "h": {"id": "C0064450", "name": "C0064450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "a", "medium", ",", "novobiocin", ",", "brilliant", "green", "glycerol", ",", "lactose", "(", "NBGL", ")", "C0026818#ent", "<e1>", ",", "for", "the", "routine", "isolation", "of", "C0036117#ent", "<e2>", "stool", "samples"], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [23, 24]}}
{"token": ["Here", "we", "demonstrate", "that", "treatment", "of", "cultured", "human", "keratinocytes", "with", "ciglitazone", ",", "a", "C1418779#ent", "<e1>", "increases", "involucrin", "and", "C0538672#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0538672", "name": "C0538672#ent", "pos": [18, 19]}}
{"token": ["These", "results", "showed", "that", "C0015133#ent", "<e1>", "does", "not", "reduce", "the", "rate", "of", "binding", "two", "C2744579#ent", "<e2>", ",", "hydrolyzing", "the", "first", "C2744579#ent", "<e2>", ",", "or", "releasing", "the", "second", "ADP", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [14, 15]}}
{"token": ["Accumulating", "evidence", "indicates", "that", "aminophylline", "[", "theophylline(2", ")", "x", "C0015091#ent", "<e1>", "]", "markedly", "attenuates", "the", "anticonvulsant", "action", "conventional", "antiepileptic", "drugs", "experimental", "animal", "models", "C0014547#ent", "<e2>", "and", "evokes", "severe", "seizure", "activity", "patients", "treated", "with", "methylxanthine", "."], "h": {"id": "C0015091", "name": "C0015091#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [23, 24]}}
{"token": ["Twenty-four", "patients", "clinically", "and", "histopathologically", "diagnosed", "as", "C2239920#ent", "<e1>", "with", "intense", "pruritus", "were", "treated", "with", "mg", "of", "enoxaparin", "(", "C0678145#ent", "<e2>", ")", ",", "subcutaneously", "once", "a", "week", "for", "4", "-", "14", "weeks", "."], "h": {"id": "C2239920", "name": "C2239920#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0678145", "name": "C0678145#ent", "pos": [19, 20]}}
{"token": ["Immunoblotting", "of", "C0009325#ent", "<e1>", "bead-associated", "complexes", "revealed", "that", "the", "tyrosine", "phosphatase", "C1335280#ent", "<e2>", ",", "was", "also", "enriched", "in", "focal", "complexes/adhesions", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335280", "name": "C1335280#ent", "pos": [11, 12]}}
{"token": ["C0010346#ent", "<e1>", "associated", "with", "inflammation", "of", "the", "bowel", ",", "severe", "abdominal", "pain", "C0011991#ent", "<e2>"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [12, 13]}}
{"token": ["Measurement", "of", "C0699918#ent", "<e1>", "real", "progress", "in", "screening", "for", "exocrine", "pancreatic", "insufficiency", "patients", "with", "C0024523#ent", "<e2>"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024523", "name": "C0024523#ent", "pos": [14, 15]}}
{"token": ["The", "C0101198#ent", "<e1>", "is", "a", "stronger", "inhibitor", "of", "both", "C0014442#ent", "<e2>", "(", "Ki", "<", "1", "microM", ")", "than", "acetylmethylphosphinate", "."], "h": {"id": "C0101198", "name": "C0101198#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["Two", "C0027203#ent", "<e1>", "forms", "of", "alkaline", "phosphatase", "been", "partially", "purified", "from", "the", "medium", "C1539835#ent", "<e2>", "for", "the", "culture", "of", "HUH-6", "clone", "5", "cells", ",", "which", "were", "originally", "derived", "from", "hepatoblastoma", "tissue"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1539835", "name": "C1539835#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "Ptp2", "and", "C4085332#ent", "<e1>", "regulate", "C3889446#ent", "<e2>", "localization", "by", "binding", "C3889446#ent", "<e2>", "."], "h": {"id": "C4085332", "name": "C4085332#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [7, 8]}}
{"token": ["In", "Saccharomyces", "cerevisiae", "two", "PTPs", ",", "Ptp2", "and", "C4085332#ent", "<e1>", ",", "inactivate", "the", "MAPKs", ",", "C3889446#ent", "<e2>", "and", "Fus3", ",", "with", "different", "specificities", "."], "h": {"id": "C4085332", "name": "C4085332#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [15, 16]}}
{"token": ["It", "was", "concluded", "that", "the", "history", "and", "features", "at", "admission", "differed", "between", "patients", "with", "and", "without", "C3887938#ent", "<e1>", "stones", "at", "ERC", "done", "during", "an", "attack", "of", "C1706339#ent", "<e2>", "."], "h": {"id": "C3887938", "name": "C3887938#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706339", "name": "C1706339#ent", "pos": [26, 27]}}
{"token": ["It", "proceeds", "through", "a", "phenolic", "coupling", "pathway", "in", "which", "the", "common", "C0949665#ent", "<e1>", "produced", "stereospecifically", "by", "C0041484#ent", "<e2>", ",", "eliminates", "an", "inorganic", "fluorine", "ion"], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041484", "name": "C0041484#ent", "pos": [16, 17]}}
{"token": ["We", "sought", "indirect", "evidence", "of", "this", "through", "an", "analysis", "of", "the", "correlation", "between", "symptom", "C0720099#ent", "<e1>", "and", "large", "fiber", "involvement", "in", "patients", "with", "C0151313#ent", "<e2>", "PSN", ")", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [23, 24]}}
{"token": ["The", "important", "time-related", "variables", "were", "found", "to", "be", "C0720099#ent", "<e1>", "of", "diabetes", "for", "retinopathy", ",", "age", "for", "macrovascular", "disease", "C0720099#ent", "<e1>", "and", "age", "at", "diagnosis", "of", "diabetes", "for", "C0151313#ent", "<e1>", "and", "age", "for", "renal", "impairment"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [28, 29]}}
{"token": ["Hepatitis", "C", "virus", "HCV", ")", "infection", "is", "associated", "with", "extrahepatic", "manifestations", "C0010403#ent", "<e1>", "membranoproliferative", "glomerulonephritis", ",", "in", "southern", "Europe", "to", "some", "extent", "with", "C0162532#ent", "<e2>"], "h": {"id": "C0010403", "name": "C0010403#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162532", "name": "C0162532#ent", "pos": [23, 24]}}
{"token": ["C1522428#ent", "<e1>", "promotes", "neuronal", "synthesis", "processing", "of", "the", "C0085151#ent", "<e2>", "thus", "favoring", "continuing", "deposition", "of", "beta-amyloid", ",", "and", "activates", "astrocytes", "and", "promotes", "astrocytic", "synthesis", "and", "release", "of", "a", "number", "of", "inflammatory", "and", "neuroactive", "molecules"], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [8, 9]}}
{"token": ["C1447694#ent", "<e1>", "is", "a", "kallikrein-like", "serine", "protease", "which", "has", "two", "alternatively", "spliced", "isoforms", "C1332763#ent", "<e2>", "and", "prostate-type", "."], "h": {"id": "C1447694", "name": "C1447694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332763", "name": "C1332763#ent", "pos": [13, 14]}}
{"token": ["Formation", "of", "complexes", "between", "C1415304#ent", "<e1>", ",", "Fgr", ",", "and", "the", "FAK-related", "protein", "C1705341#ent", "<e2>", "were", "also", "detected", "in", "murine", "macrophages", "."], "h": {"id": "C1415304", "name": "C1415304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [13, 14]}}
{"token": ["Several", "other", "diseases", "have", "been", "reported", "in", "the", "literature", ",", "including", "C0035455#ent", "<e1>", ",", "epilepsy", ",", "progressive", "C0521694#ent", "<e2>", "von", "Willebrand's", "Disease", "and", "juvenile", "fibrocartilaginous", "embolism", "."], "h": {"id": "C0035455", "name": "C0035455#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0521694", "name": "C0521694#ent", "pos": [17, 18]}}
{"token": ["It", "has", "been", "proposed", "that", "the", "YXY", "motif", "is", "an", "equivalent", "of", "the", "TXY", "motif", "the", "activation", "loop", "of", "C0752312#ent", "<e1>", "that", "phosphorylation", "at", "the", "motif", "is", "required", "for", "C1414204#ent", "<e2>", "activity", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1414204", "name": "C1414204#ent", "pos": [29, 30]}}
{"token": ["Right", "atrial", "multisite", "electrogram", "recordings", "revealed", "significant", "prolongation", "in", "C4049859#ent", "<e1>", "cycle", "length", "at", "all", "sites", "following", "C0123053#ent", "<e2>", "."], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0123053", "name": "C0123053#ent", "pos": [17, 18]}}
{"token": ["C0014310#ent", "<e1>", "was", "administered", "orally", "to", "49", "out-patients", "with", "C0042029#ent", "<e2>", "UTI", ")", "at", "the", "doses", "of", "600", "mg/day", "and", "clinical", "effects", "evaluated", "."], "h": {"id": "C0014310", "name": "C0014310#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [9, 10]}}
{"token": ["We", "describe", "the", "case", "of", "a", "patient", "with", "improving", "C0276653#ent", "<e1>", "paradoxically", "rising", "serum", "galactomannan", "levels", "in", "the", "presence", "of", "C0022661#ent", "<e2>", "ongoing", "hemodialysis", "."], "h": {"id": "C0276653", "name": "C0276653#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [20, 21]}}
{"token": ["Endogenous", "C1420706#ent", "<e1>", "can", "be", "released", "from", "the", "cell", "surface", "C0031671#ent", "<e2>", "indicating", "that", "C1420706#ent", "<e1>", "either", "is", "a", "glycosyl", "phosphatidylinositol", "protein", "or", "binds", "to", "a", "GPI-linked", "receptor"], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420706", "name": "C1420706#ent", "pos": [1, 2]}}
{"token": ["A", "provisional", "diagnosis", "C1861783#ent", "<e1>", "established", "and", "the", "patient", "was", "successfully", "treated", "with", "C0040869#ent", "<e2>", "."], "h": {"id": "C1861783", "name": "C1861783#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040869", "name": "C0040869#ent", "pos": [13, 14]}}
{"token": ["Our", "findings", "showed", "that", "the", "endogenous", "opioid", "system", "be", "related", "to", "compulsive", "drinking", "behavior", "the", "C0175697#ent", "<e1>", "that", "opioid", "antagonists", "as", "naloxone", "or", "C2343921#ent", "<e2>", "could", "be", "useful", "in", "the", "therapy", "of", "C0175697#ent", "<e1>"], "h": {"id": "C2343921", "name": "C2343921#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "C1425525#ent", "<e1>", "decreased", "the", "activation", "of", "p38", "mitogen-activated", "protein", "kinase", "MAPK", ")", "but", "not", "C4082284#ent", "<e2>", "c-jun", "N-terminal", "kinase", "and", "downstream", "tumor", "necrosis", "factor", "production", "in", "phorbol", "12-myristate", "13-acetate", "and", "calcium", "ionophore", "human", "mast", "cells"], "h": {"id": "C1425525", "name": "C1425525#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [16, 17]}}
{"token": ["The", "264th", "codon", ",", "C0069197#ent", "<e1>", "(", "serine", ")", "was", "changed", "to", "C1424942#ent", "<e2>", "(", "threonine", ")", "in", "this", "mutant", "."], "h": {"id": "C0069197", "name": "C0069197#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424942", "name": "C1424942#ent", "pos": [12, 13]}}
{"token": ["Ligand-binding", "studies", "C0034282#ent", "<e1>", "yielded", "a", "C1839259#ent", "<e2>", "value", "of", "5.5", "nM", "in", "pial", "vessel", "membranes", "and", "1.7", "nM", "in", "the", "choroid", "plexus", "confirming", "the", "presence", "of", "H1-receptors", "."], "h": {"id": "C0034282", "name": "C0034282#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [6, 7]}}
{"token": ["In", "conclusion", ",", "C0536758#ent", "<e1>", "or", "derivatives", "could", "be", "useful", "in", "the", "treatment", "of", "C0033581#ent", "<e2>", "LTB4", "seems", "to", "be", "involved", "."], "h": {"id": "C0536758", "name": "C0536758#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [14, 15]}}
{"token": ["We", "present", "the", "results", "achieved", "with", "vitamin", "(", "pyridoxine", "and", "folic", "acid", "and", "C0005304#ent", "<e1>", "(", "trimethyl-glycine", ")", "treatment", "of", "three", "patients", "with", "C0019880#ent", "<e2>", "."], "h": {"id": "C0005304", "name": "C0005304#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [23, 24]}}
{"token": ["C0022917#ent", "<e1>", "significantly", "increased", "in", "malignant", "tumors", "MCF-7", "cells", "only", "lactate", "dehydrogenase", "L-lactate", ":", "C0030016#ent", "<e2>", "EC", "1.1.1.27", "."], "h": {"id": "C0022917", "name": "C0022917#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [14, 15]}}
{"token": ["Several", "inhibitors", "of", "known", "C0022917#ent", "<e1>", "had", "no", "effect", "the", "C0030016#ent", "<e2>"], "h": {"id": "C0022917", "name": "C0022917#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [10, 11]}}
{"token": ["C0022917#ent", "<e1>", "flavocytochrome", "b2", "is", "a", "typical", "C0030016#ent", "<e2>", ",", "in", "that", "it", "accepts", "two", "electrons", "from", "the", "substrate", "but", "has", "a", "monoelectronic", "acceptor"], "h": {"id": "C0022917", "name": "C0022917#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [7, 8]}}
{"token": ["The", "C0014442#ent", "<e1>", "could", "also", "degrade", "C1420342#ent", "<e2>", ",", "vitronectin", ",", "and", "fibronectin", ",", "but", "not", "laminin", "and", "albumin", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [6, 7]}}
{"token": ["Clonidine", ",", "C0733381#ent", "<e1>", "and", "rilmenidine", "had", "similar", "effects", "on", "MAP", "and", "caused", "a", "similar", "attenuation", "of", "the", "depressor", "response", "intracisternal", "C0009014#ent", "<e2>", ",", "but", "only", "C0733381#ent", "<e1>", "attenuated", "pressor", "responses", "to", "intravenous", "alpha-methyl", "noradrenaline"], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0733381", "name": "C0733381#ent", "pos": [2, 3]}}
{"token": ["TRK-fused", "gene", "C1420703#ent", "<e1>", ")", "was", "first", "identified", "as", "a", "partner", "of", "C0919487#ent", "<e2>", "in", "generating", "the", "thyroid", "TRK-T3", "oncogene", "and", "is", "also", "involved", "in", "oncogenic", "rearrangements", "ALK", "in", "anaplastic", "lymphoma", "NOR1", "in", "mixoid", "chondrosarcoma"], "h": {"id": "C1420703", "name": "C1420703#ent", "pos": [2, 3]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0919487", "name": "C0919487#ent", "pos": [12, 13]}}
{"token": ["C1420703#ent", "<e1>", "TFG", ")", "was", "first", "identified", "as", "a", "partner", "of", "C0919487#ent", "<e2>", "in", "generating", "the", "thyroid", "TRK-T3", "oncogene", "and", "is", "also", "involved", "in", "oncogenic", "rearrangements", "ALK", "in", "anaplastic", "lymphoma", "NOR1", "in", "mixoid", "chondrosarcoma"], "h": {"id": "C1420703", "name": "C1420703#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0919487", "name": "C0919487#ent", "pos": [11, 12]}}
{"token": ["A", "novel", "GnRH", "C1258666#ent", "<e1>", "was", "seen", "at", "the", "cribriform", "bone", "C1334895#ent", "<e2>", ")", "."], "h": {"id": "C1258666", "name": "C1258666#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334895", "name": "C1334895#ent", "pos": [11, 12]}}
{"token": ["beta", "2-microglobulin", "beta", "2", "m", ")", "serum", "and", "salivary", "levels", "total", "protein", "salivary", "levels", "were", "determined", "in", "15", "patients", "with", "primary", "Sj\u00f6gren's", "syndrome", "C1832588#ent", "<e1>", ")", ",", "14", "patients", "with", "C0086981#ent", "<e2>", "11", "healthy", "subjects"], "h": {"id": "C1832588", "name": "C1832588#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0086981", "name": "C0086981#ent", "pos": [30, 31]}}
{"token": ["According", "to", "Fox", "criteria", "group", "pf", "29", "patients", "was", "divided", "into", "two", "groups", ":", "14", "patients", "with", "primary", "Sj\u00f6gren's", "syndrome", "C1832588#ent", "<e1>", ")", "and", "15", "patients", "with", "C0086981#ent", "<e2>", "SS", ")", "."], "h": {"id": "C1832588", "name": "C1832588#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0086981", "name": "C0086981#ent", "pos": [27, 28]}}
{"token": ["C0031393#ent", "<e1>", "not", "affect", "arterial", "pressure", "C0020223#ent", "<e2>", "reduces", "arterial", "pressure", "both", "drugs", "decrease", "aortic", "tensile", "strength", "and", "increase", "the", "ultrastructural", "disruption", "of", "aortic", "elastin", "collagen", "in", "the", "BAPN", "turkey", "."], "h": {"id": "C0031393", "name": "C0031393#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [6, 7]}}
{"token": ["The", "tumor", "number", "the", "descending", "colon", "C0031393#ent", "<e1>", "was", "also", "increased", "but", "the", "overall", "score", "as", "with", "the", "C0020223#ent", "<e2>", "group", ",", "was", "in", "the", "range", "of", "the", "DMH", "injected", "controls", "."], "h": {"id": "C0031393", "name": "C0031393#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [18, 19]}}
{"token": ["Neither", "binding", "of", "UK1", "to", "C2350558#ent", "<e1>", "uPA", "receptor", "competitive", "inhibition", "of", "C1538714#ent", "<e2>", "binding", "were", "confirmed", "by", "real-time", "interaction", "analysis", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1538714", "name": "C1538714#ent", "pos": [12, 13]}}
{"token": ["C0751598#ent", "<e1>", "exerts", "a", "dose-dependent", "inhibitory", "influence", "on", "C0812443#ent", "<e2>", "through", "a", "direct", "antiproliferative", "effect", "on", "megakaryocytic", "precursors"], "h": {"id": "C0751598", "name": "C0751598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [8, 9]}}
{"token": ["Of", "these", "subunits", ",", "C0010583#ent", "<e1>", "two", "nontransmembrane", "helices", "cd1", "and", "C1367475#ent", "<e2>", ",", "which", "are", "critical", "for", "its", "structure", "and", "function", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367475", "name": "C1367475#ent", "pos": [11, 12]}}
{"token": ["PKCdelta", "is", "cleaved", "by", "C0291573#ent", "<e1>", "generate", "a", "C0669365#ent", "<e2>", "active", "catalytic", "domain", "mediates", "both", "its", "apoptotic", "and", "anti-apoptotic", "effects", "."], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}}
{"token": ["Pretreatment", "with", "hexamethonium", "(", "an", "C2267059#ent", "<e1>", "1.0", "mg/kg", ")", "abolished", "the", "vasodilator", "response", "while", "C0004259#ent", "<e2>", ",", "phentolamine", ",", "propranolol", "and", "tripelennamine", "had", "no", "effect", "these", "vasoresponses", "."], "h": {"id": "C2267059", "name": "C2267059#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [15, 16]}}
{"token": ["The", "neurochemical", "differences", "between", "NCL", "and", "C1416903#ent", "<e1>", "parallel", "those", "between", "associative", "regions", "such", "as", "C1418482#ent", "<e2>", "and", "dorsal", "striatum", "mammals", "."], "h": {"id": "C1416903", "name": "C1416903#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [15, 16]}}
{"token": ["The", "shorter", "cAE3", "polypeptide", "1034", "C3539946#ent", "<e1>", "length", "corresponds", "to", "the", "rat", "C3539534#ent", "<e2>", "\"", "cardiac", "isoform"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539534", "name": "C3539534#ent", "pos": [12, 13]}}
{"token": ["Five", "disease-causing", "genes", "including", "the", "IL12RB1", "gene", "encodes", "the", "C1366325#ent", "<e1>", "IL-12R", "beta", "1", ",", "are", "known", "to", "be", "associated", "with", "C0039082#ent", "<e2>", "of", "Mendelian", "susceptibility", "mycobacterial", "diseases"], "h": {"id": "C1366325", "name": "C1366325#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [21, 22]}}
{"token": ["A", "72", "kDa", "form", "of", "cod", "gelatin", "enzyme", "had", "properties", "similar", "to", "human", "C0526871#ent", "<e1>", ",", "as", "it", "could", "be", "activated", "by", "p-aminophenylmercuric", "acetate", "C0960371#ent", "<e2>", "."], "h": {"id": "C0526871", "name": "C0526871#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [24, 25]}}
{"token": ["Genes", "C3889446#ent", "<e1>", "only", "in", "hyperplasia", "were", ":", "MDM2", ",", "MCL1", ",", "C1412761#ent", "<e2>", ",", "BLK", ",", "RIPK2", ",", "CD40LG", ",", "TRAF5", ",", "HUS1", ",", "BNIP3", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412761", "name": "C1412761#ent", "pos": [12, 13]}}
{"token": ["Antibodies", "against", "cytokeratin", ",", "desmin", ",", "vimentin", ",", "neurofilaments", ",", "C1414404#ent", "<e1>", "Leu7", ",", "synaptophysin", ",", "chromogranin", ",", "the", "C0968461#ent", "<e2>", "the", "Von", "Willebrand", "factor", "the", "common", "leucocyte", "antigen", "used", "in", "a", "biotin-streptavidin", "procedure", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0968461", "name": "C0968461#ent", "pos": [19, 20]}}
{"token": ["Eight", "tumors", "stained", "for", "vimentin", ",", "eight", "for", "desmin", ",", "eight", "for", "C1414404#ent", "<e1>", "two", "for", "C0968461#ent", "<e2>", "and", "one", "for", "fast", "myosin"], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0968461", "name": "C0968461#ent", "pos": [16, 17]}}
{"token": ["Novel", "C0017337#ent", "<e1>", "associated", "with", "iron", "uptake", "Dcytb", ",", "a", "putative", "iron-regulated", "reductase", "and", "C1833296#ent", "<e2>", ",", "a", "Fe(II", ")", "carrier", "in", "the", "brush", "border", "membrane"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1833296", "name": "C1833296#ent", "pos": [14, 15]}}
{"token": ["We", "assessed", "the", "safety", "and", "efficacy", "of", "a", "once", "daily", "dose", "of", "C0540694#ent", "<e1>", "an", "open-label", "trial", "for", "the", "treatment", "of", "lamivudine-resistant", "C0019163#ent", "<e2>", "infection", "in", "HIV-1-infected", "patients", "."], "h": {"id": "C0540694", "name": "C0540694#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [22, 23]}}
{"token": ["Of", "the", "inhibitors", "utilized", ",", "hemagglutination", "activity", "of", "C1413599#ent", "<e1>", "is", "inhibited", "only", "by", "C0024727#ent", "<e2>", ",", "whereas", "FBL", "activity", "is", "inhibited", "by", "several", "glycosubstances", "."], "h": {"id": "C1413599", "name": "C1413599#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024727", "name": "C0024727#ent", "pos": [14, 15]}}
{"token": ["Two", "other", "C1335824#ent", "<e1>", "genes", ",", "PtdTPS2", "and", "PtTPS3", ",", "and", "C3888279#ent", "<e2>", "only", "very", "transiently", "induced", "."], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3888279", "name": "C3888279#ent", "pos": [11, 12]}}
{"token": ["The", "safety", "profile", "of", "C1700695#ent", "<e1>", "was", "somewhat", "more", "favorable", "under", "C0033487#ent", "<e2>", "than", "under", "sevoflurane", "anesthesia"], "h": {"id": "C1700695", "name": "C1700695#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [11, 12]}}
{"token": ["Transfection", "experiments", "show", "that", "phosphorylation", "of", "Vav", "on", "tyrosine", "residues", "leads", "to", "nucleotide", "exchange", "C3274857#ent", "<e1>", "in", "vivo", "stimulates", "c-Jun", "kinase", "a", "downstream", "element", "the", "signalling", "pathway", "this", "C0018296#ent", "<e2>", "."], "h": {"id": "C3274857", "name": "C3274857#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [28, 29]}}
{"token": ["Etoposide", "phosphate", "Etopophos", ",", "C0286313#ent", "<e1>", ")", "is", "a", "water-soluble", "derivative", "the", "widely", "used", "podophyllotoxin", "etoposide", "C0733688#ent", "<e2>", ")", "."], "h": {"id": "C0286313", "name": "C0286313#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0733688", "name": "C0733688#ent", "pos": [16, 17]}}
{"token": ["The", "inhibitory", "effects", "of", "cimetidine", ",", "C0085154#ent", "<e1>", "and", "omeprazole", "on", "the", "metabolic", "activity", "CYP2C9", ",", "2C19", ",", "C0057223#ent", "<e2>", "and", "3A", "were", "investigated", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0085154", "name": "C0085154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0057223", "name": "C0057223#ent", "pos": [18, 19]}}
{"token": ["C1567966#ent", "<e1>", "are", "selective", "C0162757#ent", "<e2>", "are", "specific", "and", "effective", "treatments", "in", "the", "management", "of", "migraine", ",", "and", "they", "meet", "the", "acute", "treatment", "of", "rapid", "relief", "with", "minimal", "side", "effects"], "h": {"id": "C1567966", "name": "C1567966#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162757", "name": "C0162757#ent", "pos": [4, 5]}}
{"token": ["It", "was", "demonstrated", "that", "C1138321#ent", "<e1>", "combination", "with", "second", "line", "drugs", "C0041296#ent", "<e2>", "treatment", "(", "cycloserine", "+", "rifabutine", ",", "cycloserine", "+", "protionamide", ")", "provided", "statistically", "significant", "decrease", "of", "intracellular", "mycobacteria", "growth", "in", "the", "murine", "lung", "tissue", "culture"], "h": {"id": "C1138321", "name": "C1138321#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [11, 12]}}
{"token": ["Indications", "for", "the", "use", "of", "C1138321#ent", "<e1>", "in", "the", "treatment", "of", "C0041296#ent", "<e2>", "are", "specified", "on", "the", "basis", "of", "the", "baseline", "immunological", "parameters", "of", "each", "patient", "."], "h": {"id": "C1138321", "name": "C1138321#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [11, 12]}}
{"token": ["A", "more", "reasonable", "explanation", "may", "be", "that", "permeability", "of", "the", "C1420193#ent", "<e1>", "anions", "may", "be", "reduced", "by", "these", "C0035064#ent", "<e2>", "."], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [18, 19]}}
{"token": ["This", "lack", "of", "activity", "of", "C0025872#ent", "<e1>", "against", "N.", "gonorrhoeae", "suggest", "that", "the", "ability", "to", "recover", "N.", "gonorrhoeae", "patients", "being", "treated", "with", "C0025872#ent", "<e1>", "for", "concurrent", "C0040923#ent", "<e1>", "not", "be", "hampered", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0040923", "name": "C0040923#ent", "pos": [26, 27]}}
{"token": ["To", "determine", "the", "minimum", "effective", "dose", "of", "C0025872#ent", "<e1>", "in", "the", "treatment", "of", "C0040923#ent", "<e2>", "a", "randomised", "clinical", "trial", "single", "1-g", "and", "2-g", "doses", "was", "carried", "out", "on", "163", "patients", "attending", "sexually", "transmitted", "diseases", "family", "planning", "clinics"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0040923", "name": "C0040923#ent", "pos": [13, 14]}}
{"token": ["Treatment", "with", "both", "proteasome", "inhibitors", "in", "apoptosis", "induction", ",", "whereas", "the", "combinations", "with", "C0122812#ent", "<e1>", "generally", "did", "not", ",", "with", "the", "exception", "of", "C0289053#ent", "<e2>", "combined", "with", "10(-7", ")", "M", "C0122812#ent", "<e1>", "."], "h": {"id": "C0289053", "name": "C0289053#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0122812", "name": "C0122812#ent", "pos": [13, 14]}}
{"token": ["Downregulation", "of", "GSH", "by", "L-buthionine-(S", ",", "R)-sulfoxime", "(", "BSO", ")", ",", "a", "specific", "inhibitor", "of", "glutathione", "synthesis", ",", "reversed", "C2713546#ent", "<e1>", "in", "activation", "of", "apoptosis", "pathways", "by", "anticancer", "drugs", "C1539477#ent", "<e2>", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [29, 30]}}
{"token": ["The", "gamma-glutamyl", "analogs", "6-diazo-5-oxo-L-norleucine", "(", "DON", ")", "and", "C0004480#ent", "<e1>", "inactivate", "the", "human", "kidney", "enzyme", "with", "respect", "to", "its", "C0007074#ent", "<e2>", "and", "hydrolase", "activities", "."], "h": {"id": "C0004480", "name": "C0004480#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007074", "name": "C0007074#ent", "pos": [19, 20]}}
{"token": ["C0033806#ent", "<e1>", "characterized", "by", "the", "presence", "of", "polyostotic", "fibrous", "dysplasia", "endocrinopathies", "and", "C0015230#ent", "<e2>", "the", "skin", "."], "h": {"id": "C0033806", "name": "C0033806#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [12, 13]}}
{"token": ["The", "role", "of", "glucocorticoid", "receptor", "mediation", "in", "C1335596#ent", "<e1>", "eNOS", "changes", "was", "investigated", "with", "the", "glucocorticoid", "receptor", "antagonist", "C0026088#ent", "<e2>", "."], "h": {"id": "C1335596", "name": "C1335596#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026088", "name": "C0026088#ent", "pos": [18, 19]}}
{"token": ["The", "patient", "clinically", "showed", "C0234533#ent", "<e1>", "choreatic", "involuntary", "movements", "hypotonia", ",", "areflexia", ",", "neurogenic", "muscular", "atrophy", "tongue-biting", "and", "C0000744#ent", "<e2>", "of", "the", "peripheral", "blood", "died", "from", "asphyxia", "at", "the", "age", "of", "34", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [18, 19]}}
{"token": ["Oral", "C0009011#ent", "<e1>", "has", "proved", "useful", "as", "adjunctive", "therapy", "generalised", "absence", "seizures", "C0014550#ent", "<e2>", "and", "partial", "seizures"], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0014550", "name": "C0014550#ent", "pos": [12, 13]}}
{"token": ["To", "clarify", "the", "role", "of", "the", "intrarenal", "renin-angiotensin", "system", "modulating", "C1427067#ent", "<e1>", "pressure-natriuresis", ",", "C1427067#ent", "<e1>", "were", "given", "lifelong", "C0065374#ent", "<e1>", "by", "treating", "C1427067#ent", "<e1>", "and", "their", "mothers", "before", "conception", "."], "h": {"id": "C1427067", "name": "C1427067#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [19, 20]}}
{"token": ["Purified", "centrosomes", "also", "contain", "Skp1", ",", "and", "C1332809#ent", "<e1>", "modified", "by", "the", "ubiquitin-like", "molecule", "C1417663#ent", "<e2>", ",", "suggesting", "a", "role", "for", "C1417663#ent", "<e2>", "in", "targeting", "."], "h": {"id": "C1332809", "name": "C1332809#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417663", "name": "C1417663#ent", "pos": [14, 15]}}
{"token": ["The", "present", "report", "describes", "a", "second", "passage", "in", "cattle", ",", "carried", "out", "because", "C0012634#ent", "<e1>", "caused", "by", "the", "spongiform", "encephalopathy", "C0991617#ent", "<e2>", "often", "change", "in", "character", "with", "additional", "passages", "in", "abnormal", "hosts", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [20, 21]}}
{"token": ["In", "the", "intestinal", "tract", "C1420200#ent", "<e1>", "is", "expressed", "in", "the", "proximal", "parts", ",", "whereas", "C1426025#ent", "<e2>", "is", "expressed", "in", "the", "distal", "parts"], "h": {"id": "C1420200", "name": "C1420200#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1426025", "name": "C1426025#ent", "pos": [14, 15]}}
{"token": ["C1414260#ent", "<e1>", "involved", "in", "physiological", "processes", "vascular", "tone", "mitogenesis", ",", "whereas", "under", "pathological", "conditions", "fibrosis", "C0020538#ent", "<e2>", "inflammation", "are", "induced", "."], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [0, 1]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [15, 16]}}
{"token": ["Effects", "of", "xanthine", "derivatives", "pentoxifylline", ",", "caffeine", ",", "theophylline", ",", "C0000096#ent", "<e1>", ")", "on", "P-glycoprotein", "mediated", "C0042679#ent", "<e2>", "L1210/VCR", "mouse", "leukemic", "cell", "subline", "studied", "."], "h": {"id": "C0000096", "name": "C0000096#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [16, 17]}}
{"token": ["The", "C1307941#ent", "<e1>", "encodes", "a", "new", "type", "of", "C1566416#ent", "<e2>", "respect", "to", "possessing", "the", "thrombospondin", "(", "TSP", ")", "type", "I", "motifs"], "h": {"id": "C1307941", "name": "C1307941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1566416", "name": "C1566416#ent", "pos": [8, 9]}}
{"token": ["HoloCRBP", "delivers", "retinol", "to", "a", "microsomal", "nicotin-amide-adenine", "dinucleotide", "C0687684#ent", "<e1>", "protects", "it", "from", "artifactual", "oxidation", "and", "denies", "C3540790#ent", "<e2>", "that", "can", "not", "recognize", "the", "binding", "protein", "to", "retinol", "."], "h": {"id": "C0687684", "name": "C0687684#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [17, 18]}}
{"token": ["C0596110#ent", "<e1>", "were", "positively", "associated", "with", "cardiac", "failure", "ischaemic", "heart", "disease", "airflow", "obstruction", "and", "C0021831#ent", "<e2>", "negatively", "with", "Parkinson's", "disease"], "h": {"id": "C0596110", "name": "C0596110#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [14, 15]}}
{"token": ["The", "regulatory", "activity", "C1706870#ent", "<e1>", ",", "a", "member", "of", "the", "LysR", "family", "of", "C0812312#ent", "<e2>", "is", "mediated", "in", "part", "through", "its", "binding", "to", "conserved", "DNA", "sequences", "nod", "boxes", "which", "lie", "upstream", "of", "the", "inducible", "nod", "genes"], "h": {"id": "C1706870", "name": "C1706870#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [13, 14]}}
{"token": ["However", ",", "long-term", "elevation", "of", "bGH", "was", "generally", "detrimental", "to", "health", ":", "the", "pigs", "had", "a", "high", "incidence", "of", "C0038358#ent", "<e1>", "arthritis", ",", "cardiomegaly", ",", "dermatitis", ",", "and", "C0035086#ent", "<e2>"], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [28, 29]}}
{"token": ["Such", "specific", "factors", "include", "the", "following", ":", "antioxLDL", "and", "anti", "CRP", "antibodies", ",", "immune", "complexes", "C0065661#ent", "<e1>", "disturbances", "of", "metabolism", "of", "annexin", "A5", "antiphospholipid", "syndrome", "immunologically", "determined", "C0242339#ent", "<e2>", ",", "influence", "of", "medication", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0242339", "name": "C0242339#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "stretch-dependent", "C1413791#ent", "<e1>", "promoter", "activity", "significantly", "reduced", "upon", "inhibition", "of", "either", "phosphatidylinositol", "3-kinase", "C0380241#ent", "<e2>", "or", "RhoA", "GTPase", "was", "completely", "abolished", "upon", "inhibition", "of", "actin", "polymerization"], "h": {"id": "C1413791", "name": "C1413791#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0380241", "name": "C0380241#ent", "pos": [15, 16]}}
{"token": ["Evidence", "has", "shown", "that", "protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "epsilon", "is", "a", "C0029016#ent", "<e2>", "may", "play", "a", "role", "in", "HNSCC", "progression", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [13, 14]}}
{"token": ["Additionally", ",", "the", "C3149631#ent", "<e1>", "and", "SP", "groups", "demonstrated", "decreased", "immunoreactive", "C1706334#ent", "<e2>", "levels", "during", "spontaneous", "recrudescence", "."], "h": {"id": "C3149631", "name": "C3149631#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706334", "name": "C1706334#ent", "pos": [11, 12]}}
{"token": ["For", "example", "if", "this", "hazard", "ratio", "a", "gamma", "distribution", "the", "optimal", "test", "is", "a", "member", "of", "the", "\"", "C0174045#ent", "<e1>", "class", "introduced", "by", "C0018606#ent", "<e2>", "1982", ")", "."], "h": {"id": "C0174045", "name": "C0174045#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0018606", "name": "C0018606#ent", "pos": [23, 24]}}
{"token": ["These", "studies", "concern", "screening", "for", "thyroid", "disease", "C0040128#ent", "<e1>", "treatment", "with", "iodine-131", ",", "antithyroid", "drug", ",", "treatment", "of", "C0020676#ent", "<e2>", ",", "and", "management", "of", "thyroid", "nodules"], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [18, 19]}}
{"token": ["12", "LD", "patients", "had", "end-stage", "cystic", "fibrosis", "4", "had", "C0152171#ent", "<e1>", "and", "1", "child", "had", "C0006272#ent", "<e2>"], "h": {"id": "C0152171", "name": "C0152171#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0006272", "name": "C0006272#ent", "pos": [15, 16]}}
{"token": ["Brucellosis", ",", "C0034494#ent", "<e1>", ",", "salmonellosis", ",", "anthrax", "and", "C0013502#ent", "<e2>", "are", "among", "the", "main", "zoonotic", "diseases", "constitute", "a", "threat", "to", "human", "health", "and", "welfare", "."], "h": {"id": "C0034494", "name": "C0034494#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [9, 10]}}
{"token": ["Based", "on", "partial", "peptide", "sequences", "of", "the", "C0014442#ent", "<e1>", ",", "we", "molecularly", "cloned", "the", "C1333402#ent", "<e2>", "which", "encodes", "a", "protein", "with", "a", "predicted", "molecular", "mass", "about", "93", "kDa", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [14, 15]}}
{"token": ["Transfection", "experiments", "for", "C1425259#ent", "<e1>", "and", "2", "30", "%", "to", "40", "%", "and", "C3889450#ent", "<e2>", "75", "%", "of", "the", "wildtype", "(", "wt", ")", "S-promoter", "activity", "."], "h": {"id": "C1425259", "name": "C1425259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889450", "name": "C3889450#ent", "pos": [13, 14]}}
{"token": ["On", "the", "other", "hand", ",", "central", "core", "disease", "C0008928#ent", "<e1>", ")", "is", "a", "C0019247#ent", "<e2>", "primarily", "involves", "the", "skeletal", "muscles", "but", "can", "present", "articular", "deformities", "secondary", "to", "muscular", "weakness"], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [13, 14]}}
{"token": ["LO", "potently", "downregulated", "the", "PI3K", "C0812228#ent", "<e1>", "while", "partially", "inhibiting", "C1367675#ent", "<e2>", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367675", "name": "C1367675#ent", "pos": [10, 11]}}
{"token": ["Screening", "of", "a", "panel", "of", "cystatin", "superfamily", "members", "showed", "that", "type", "1", "inhibitors", "cystatins", "A", "B", ")", "and", "C0086509#ent", "<e1>", "type", "3", ")", "did", "not", "inhibit", "pig", "C0104398#ent", "<e2>", "."], "h": {"id": "C0086509", "name": "C0086509#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0104398", "name": "C0104398#ent", "pos": [27, 28]}}
{"token": ["The", "phenotypic", "differences", "between", "C1279481#ent", "<e1>", "and", "IL-2-deficient", "SCID", "suggests", "that", "the", "C1706035#ent", "<e2>", "be", "a", "component", "of", "other", "receptors", "needed", "for", "thymic", "development", "B", "cell", "class-switching", ",", "and", "NK", "development", "."], "h": {"id": "C1279481", "name": "C1279481#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706035", "name": "C1706035#ent", "pos": [12, 13]}}
{"token": ["In", "F2(S", "x", "C3810599#ent", "<e1>", ")", "functionally", "variant", "C0002085#ent", "<e2>", "at", "both", "QTL", "influence", "blood", "pressure", "but", "in", "F2(S", "x", "WKY", ")", "only", "the", "QTL", "marked", "by", "Nos2", "is", "segregating", "alleles", "influencing", "blood", "pressure"], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [8, 9]}}
{"token": ["COCH", "is", "not", "the", "C3810599#ent", "<e1>", "gene", "detected", "in", "our", "linkage", "study", "furthermore", ",", "COCH", "and", "C3810599#ent", "<e1>", "are", "not", "C0002085#ent", "<e1>", "."], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [20, 21]}}
{"token": ["The", "role", "of", "a", "bile", "salt", "sodium", "taurocholate", "and", "lipolysis", "products", "C0017860#ent", "<e1>", "and", "fatty", "acid", "in", "the", "intestinal", "absorption", "a", "poorly", "water-soluble", "drug", "C0012010#ent", "<e2>", ",", "was", "investigated", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [24, 25]}}
{"token": ["The", "role", "of", "DNA", "methylation", "mood", "regulation", "indicated", "by", "the", "antimanic", "effect", "C0037567#ent", "<e1>", ",", "a", "histone", "deacetylase", "inhibitor", "and", "the", "C0003289#ent", "<e2>", "S-adenosyl", "methionine", "a", "methyl", "donor", "DNA", "methylation"], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [12, 13]}, "relation": "has_therapeutic_class", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [21, 22]}}
{"token": ["Here", "we", "demonstrate", "that", "C0037567#ent", "<e1>", "strongly", "and", "reversibly", "potentiates", "the", "C0003289#ent", "<e2>", "effects", "of", "the", "GABA-A", "receptor", "agonist", "muscimol", "on", "locus", "coeruleus", "neurones", "recorded", "extracellularly", "from", "a", "midpontine", "slice", "preparation", "of", "the", "rat", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [4, 5]}, "relation": "has_therapeutic_class", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [11, 12]}}
{"token": ["As", "the", "catecholamine", "formed", "appears", "to", "be", "a", "good", "substrate", "for", "C1135159#ent", "<e1>", ",", "in-vivo", "catecholamine", "formation", "in", "rats", "from", "C0068168#ent", "<e2>", "was", "only", "detectable", "after", "inhibition", "of", "COMT", "by", "tropolone", "."], "h": {"id": "C1135159", "name": "C1135159#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0068168", "name": "C0068168#ent", "pos": [20, 21]}}
{"token": ["These", "data", "provide", "a", "rationale", "for", "the", "novel", "therapeutic", "targeting", "of", "C1705975#ent", "<e1>", "using", "the", "humanized", "2B6", "MoAb", "in", "patients", "with", "systemic", "C0268381#ent", "<e2>", "."], "h": {"id": "C1705975", "name": "C1705975#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268381", "name": "C0268381#ent", "pos": [22, 23]}}
{"token": ["Only", "sstr2", "seems", "to", "be", "involved", "in", "the", "control", "of", "chicken", "C3539616#ent", "<e1>", "release", ",", "whereas", "both", "sstr2", "and", "C1335870#ent", "<e2>", "inhibit", "induced", "C3539616#ent", "<e1>", "secretion", "in", "mammals", "."], "h": {"id": "C1335870", "name": "C1335870#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [11, 12]}}
{"token": ["Three", "children", "developed", "C0149871#ent", "<e1>", "DVT", ")", "along", "with", "C0029443#ent", "<e2>", "of", "the", "femur", "."], "h": {"id": "C0149871", "name": "C0149871#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [9, 10]}}
{"token": ["Monooxygenase", "enzyme", "activity", "C0015110#ent", "<e1>", "amidopyrin", "N-demethylase", "analgin", "N-demethylase", ",", "aniline", "hydroxylase", "cytochrome", "P-450", "content", "and", "C4078840#ent", "<e2>", "CCR", "]", ")", "was", "determined", "in", "liver", "9000", "x", "g", "supernatant", "."], "h": {"id": "C0015110", "name": "C0015110#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4078840", "name": "C4078840#ent", "pos": [16, 17]}}
{"token": ["We", "have", "isolated", "mutants", "defective", "in", "one", "of", "the", "three", "proteolytic", "activities", "the", "C0026741#ent", "<e1>", "i.e.", "in", "cleavage", "of", "peptide", "bonds", "C0815040#ent", "<e2>"], "h": {"id": "C0026741", "name": "C0026741#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [21, 22]}}
{"token": ["The", "recurrent", "C0000737#ent", "<e1>", "interpreted", "as", "manifestations", "of", "C0751115#ent", "<e2>", "and", "effective", "and", "long-lasting", "treatment", "was", "obtained", "with", "carbamazepine", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751115", "name": "C0751115#ent", "pos": [8, 9]}}
{"token": ["RT-PCR", "analyses", "tissue-restricted", "expression", "of", "the", "three", "C0017337#ent", "<e1>", "with", "both", "VMD2L1", "and", "C1826424#ent", "<e2>", "abundantly", "transcribed", "in", "colon", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826424", "name": "C1826424#ent", "pos": [13, 14]}}
{"token": ["P21", "is", "a", "C0086903#ent", "<e1>", "can", "contribute", "to", "cell", "cycle", "arrest", "inhibiting", "the", "C0080054#ent", "<e2>", "(", "cdks", ")", "."], "h": {"id": "C0086903", "name": "C0086903#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [13, 14]}}
{"token": ["The", "metabolic", "crisis", "of", "the", "C0268583#ent", "<e1>", "aggravated", "the", "C0011849#ent", "<e2>", "and", "may", "explain", "the", "failure", "of", "insulin", "therapy", "."], "h": {"id": "C0268583", "name": "C0268583#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["However", ",", "a", "novel", "exon", "coding", "only", "three", "C3539946#ent", "<e1>", "detected", "that", "is", "not", "present", "in", "the", "C1868501#ent", "<e2>", "whose", "C3539946#ent", "<e1>", "also", "not", "found", "in", "mouse", "renin", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1868501", "name": "C1868501#ent", "pos": [17, 18]}}
{"token": ["Hence", ",", "senescent", "rats", "were", "more", "sensitive", "to", "the", "pharmacologic", "actions", "a", "cholinergic", "C0243192#ent", "<e1>", ",", "but", "less", "responsive", "than", "young", "rats", "to", "a", "C3536931#ent", "<e2>"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3536931", "name": "C3536931#ent", "pos": [24, 25]}}
{"token": ["Northern", "blot", "analysis", "RT-PCR", "showed", "that", "no", "C2985152#ent", "<e1>", "mRNA", "is", "present", "in", "C0771711#ent", "<e2>", "from", "fasted", "rats", "and", "in", "the", "rat", "pancreas", "carcinoma", "cell", "line", "AR4", "-", "2J", "in", "its", "protodifferentiated", "state"], "h": {"id": "C2985152", "name": "C2985152#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [13, 14]}}
{"token": ["The", "geNorm(ATZ", ")", "approach", "was", ",", "in", "addition", ",", "applicable", "to", "adenocarcinomas", ";", "C2985152#ent", "<e1>", "was", "overexpressed", "(", "P", "<", "0.04", ")", "in", "malignant", "colon", "C0771711#ent", "<e2>", ",", "and", "breast", "tumors", "with", "normal", "tissues"], "h": {"id": "C2985152", "name": "C2985152#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [25, 26]}}
{"token": ["A", "decrease", "of", "blood", "pressure", "C0003364#ent", "<e1>", "in", "the", "normalization", "of", "C1846142#ent", "<e2>", "abnormalities", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1846142", "name": "C1846142#ent", "pos": [11, 12]}}
{"token": ["Proteolysis", "led", "to", "dissociation", "of", "the", "B", "subunit", "the", "C0026741#ent", "<e1>", "correlated", "with", "an", "increase", "in", "cardiac", "myosin", "light", "chain", "C0027120#ent", "<e2>", "and", "Leu-Arg-Arg-Ala-Ser-Leu-Gly", "(", ")", "phosphatase", "activity", "."], "h": {"id": "C0026741", "name": "C0026741#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027120", "name": "C0027120#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "the", "amounts", "of", "neurotrophin", "receptor", "p75", ",", "C0919487#ent", "<e1>", ",", "TrkC", ")", "mRNAs", "in", "the", "vagus", "nerve", "vagal", "afferent", "C0085648#ent", "<e2>", "not", "reduced", "in", "diabetic", "rats", "."], "h": {"id": "C0919487", "name": "C0919487#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [21, 22]}}
{"token": ["C1426677#ent", "<e1>", "stimulation", "at", "the", "C0796516#ent", "<e2>", "did", "not", "evoke", "afterdischarge", "5", "min", "after", "the", "injection", ",", "although", "the", "kindled", "seizure", "was", "reactivated", "by", "a", "more", "intense", "stimulus", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0796516", "name": "C0796516#ent", "pos": [5, 6]}}
{"token": ["Addition", "of", "human", "tissue", "plasminogen", "activator", "C0872913#ent", "<e1>", ")", "leader", "sequence", "the", "N", "terminus", "of", "C0017356#ent", "<e2>", ",", "which", "concomitantly", "inactivates", "the", "myristoylation", "site", ",", "significantly", "enhanced", "the", "Nef-specific", "T", "cell", "responses", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017356", "name": "C0017356#ent", "pos": [15, 16]}}
{"token": ["C1333714#ent", "<e1>", ",", "neuropeptide", "Y", "neurotensin", "and", "C1418447#ent", "<e2>", "were", "less", "common", ";", "and", "enkephalin", "was", "present", "in", "only", "a", "small", "percentage", "of", "projection", "neurons.(ABSTRACT", "TRUNCATED", "AT", "400", "WORDS", ")"], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418447", "name": "C1418447#ent", "pos": [7, 8]}}
{"token": ["The", "ulcers", "did", "not", "respond", "to", "the", "treatment", "regimen", "C0017575#ent", "<e1>", "but", "responded", "to", "treatment", "of", "their", "C0023530#ent", "<e2>", "."], "h": {"id": "C0017575", "name": "C0017575#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [17, 18]}}
{"token": ["Studies", "with", "special", "chemical", "inhibitors", "that", "this", "process", "involved", "C0033681#ent", "<e1>", "transducer", "and", "activator", "of", "transcription", "STAT", ")", ",", "C0752312#ent", "<e2>", "MAPK", ")", ",", "and", "phosphatidylinositol", "3-linase", "kinase", "B", "AKT", ")", "signal", "pathways"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [19, 20]}}
{"token": ["Previous", "studies", "demonstrated", "that", "lysoPC", "can", "induce", "various", "protein", "kinases", "C0033681#ent", "<e1>", "protein", "kinase", "C", "PKC", ")", ",", "and", "C0752312#ent", "<e2>", "MAPK", ")", "in", "vascular", "endothelial", "cells"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [19, 20]}}
{"token": ["These", "data", "are", "consistent", "with", "concept", "that", "endogenous", "generation", "of", "C2698414#ent", "<e1>", "from", "[des-Asp1]AI", "can", "occur", "via", "the", "action", "of", "converting", "C0014442#ent", "<e2>", "on", "this", "substance", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["We", "reported", "previously", "that", "Ca", "and", "Pi", "levels", "are", "elevated", "and", "alkaline", "phosphatase", "C1706468#ent", "<e1>", ")", "activity", "and", "1alpha,25(OH)2D3", "levels", "are", "reduced", "in", "C0008286#ent", "<e2>", "(CPZ)-challenged", "rats", "."], "h": {"id": "C1706468", "name": "C1706468#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0008286", "name": "C0008286#ent", "pos": [23, 24]}}
{"token": ["A", "case", "of", "C0268412#ent", "<e1>", "presenting", "with", "C0020437#ent", "<e2>", "is", "described", "and", "the", "histological", "and", "radiological", "resolution", "of", "the", "mineralisation", "defect", "present", "initially", "are", "reported", "."], "h": {"id": "C0268412", "name": "C0268412#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [7, 8]}}
{"token": ["Severe", "C1956346#ent", "<e1>", "the", "rule", ",", "with", "three", "C0042373#ent", "<e2>", "nearly", "70", "%", "of", "cases", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [8, 9]}}
{"token": ["However", ",", "aortic", "root", "of", "contrast", "material", "provide", "adequate", "definition", "of", "these", "structures", "and", "has", "been", "recommended", "as", "a", "screening", "technique", "C1956346#ent", "<e1>", "patients", "undergoing", "arteriography", "for", "other", "C0042373#ent", "<e2>"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [21, 22]}, "relation": "related_to", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [28, 29]}}
{"token": ["C0236000#ent", "<e1>", "morphological", "homologues", "in", "the", "molar", "series", "also", "exhibit", "complete", "C1335278#ent", "<e2>", "."], "h": {"id": "C0236000", "name": "C0236000#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335278", "name": "C1335278#ent", "pos": [11, 12]}}
{"token": ["There", "was", "a", "small", ",", "but", "statistically", "significant", "increase", "in", "C0596123#ent", "<e1>", "after", "exposure", "to", "ppm", "C1414404#ent", "<e2>", "in", "ambient", "air", "."], "h": {"id": "C0596123", "name": "C0596123#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414404", "name": "C1414404#ent", "pos": [16, 17]}}
{"token": ["However", ",", "the", "relative", "contribution", "of", "C3539768#ent", "<e1>", "the", "release", "of", "C0796254#ent", "<e2>", "in", "cells", "expressing", "cyclooxygenase-2", "is", "not", "clear", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [11, 12]}}
{"token": ["Prostaglandin", "(", "C0796254#ent", "<e1>", ")", "is", "regulated", "by", "arachidonic", "acid", "AA", ")", "release", "by", "C3539768#ent", "<e2>", "PLA2", ")", "and", "its", "conversion", "to", "C0796254#ent", "<e1>", "by", "cyclooxygenase", "(", "COX", ")", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [2, 3]}}
{"token": ["An", "abasic", "lesion", "located", "within", "a", "substrate", "DNA", "strand", "C0757188#ent", "<e1>", "nucleolytic", "degradation", ",", "and", "a", "5'-terminal", "abasic", "residue", "reduces", "C0597094#ent", "<e2>", "efficiency", "2-fold", "."], "h": {"id": "C0757188", "name": "C0757188#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0597094", "name": "C0597094#ent", "pos": [20, 21]}}
{"token": ["Headache", ",", "nuchal", "rigidity", "positive", "Kernig's", "sign", "and", "even", "convulsions", "may", "be", "observed", "during", "severe", "C0004623#ent", "<e1>", "as", "pneumonia", ",", "C0034186#ent", "<e2>", ",", "typhoid", "fever", "and", "bacillary", "dysentery"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [20, 21]}}
{"token": ["Animals", "in", "Group", "2", "C1412362#ent", "<e1>", "washout", "consisting", "of", "100,000U", "C1522670#ent", "<e2>", "given", "via", "a", "pressurized", "delivery", "system", "followed", "by", "7,500", "IU", "SOD", "."], "h": {"id": "C1412362", "name": "C1412362#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522670", "name": "C1522670#ent", "pos": [10, 11]}}
{"token": ["The", "use", "of", "MKC-442", "in", "a", "two-", "or", "three-drug", "combination", "regimen", "with", "other", "C0003015#ent", "<e1>", "a", "proteinase", "inhibitor", "an", "C1417132#ent", "<e2>", "inhibitor", "should", "be", "considered", "for", "HIV-1-related", "chemotherapy", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417132", "name": "C1417132#ent", "pos": [19, 20]}}
{"token": ["Co-immunoprecipitations", "and", "subnuclear", "co-localization", "studies", "show", "that", "C1826634#ent", "<e1>", "interacts", "with", "the", "mouse", "polycomb-group", "oncoprotein", "C1826623#ent", "<e2>", "and", "is", "a", "new", "member", "of", "the", "mouse", "polycomb", "multiprotein", "complex"], "h": {"id": "C1826634", "name": "C1826634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1826623", "name": "C1826623#ent", "pos": [15, 16]}}
{"token": ["Immunological", "studies", "the", "carboxypeptidase", "Y", "mutant", "prcl-l", "Saccharomyces", "cerevisiae", "revealed", "the", "origin", "of", "mutation", "in", "the", "structural", "gene", "C0033993#ent", "<e1>", "absence", "of", "C0108471#ent", "<e2>", "no", "effect", "growth", ",", "even", "after", "drastic", "changes", "of", "growth", "conditions"], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [22, 23]}}
{"token": ["The", "changes", "in", "LDL-Rm", "ratio", "and", "preheparin", "C1705159#ent", "<e1>", "mass", "were", "independent", "of", "the", "hypoglycemic", "effect", "of", "C0025598#ent", "<e2>", "."], "h": {"id": "C1705159", "name": "C1705159#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [17, 18]}}
{"token": ["Here", ",", "using", "biochemical", "assays", "we", "show", "that", "huntingtin", "(", "C3814032#ent", "<e1>", ")", "interacting", "protein", ",", "C1538168#ent", "<e2>", ",", "is", "a", "neuronal", "palmitoyl", "transferase", "PAT", ")", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1538168", "name": "C1538168#ent", "pos": [16, 17]}}
{"token": ["Downregulation", "of", "C1538168#ent", "<e1>", "in", "mouse", "neurons", "expressing", "wild-type", "and", "mutant", "C3814032#ent", "<e2>", "increases", "inclusion", "formation", "whereas", "overexpression", "of", "C1538168#ent", "<e1>", "substantially", "reduces", "inclusions", "."], "h": {"id": "C3814032", "name": "C3814032#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1538168", "name": "C1538168#ent", "pos": [2, 3]}}
{"token": ["The", "effects", "of", "noscapine", "and", "chlorpheniramine", "on", "physical", "dependence", "and", "C0003449#ent", "<e1>", "dihydrocodeine", ",", "a", "C0003449#ent", "<e1>", "were", "studied", "."], "h": {"id": "C0003449", "name": "C0003449#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003449", "name": "C0003449#ent", "pos": [10, 11]}}
{"token": ["Several", "inhibitors", "of", "the", "C0286330#ent", "<e1>", "increased", "the", "level", "of", "C1705628#ent", "<e2>", "in", "the", "Caski", "cells", "."], "h": {"id": "C0286330", "name": "C0286330#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705628", "name": "C1705628#ent", "pos": [10, 11]}}
{"token": ["To", "observe", "effects", "of", "phytoestrogens", "quercetin", "QC", ")", ",", "Genistein", "(", "GEN", ")", ",", "C0010209#ent", "<e1>", "(", "COM", ")", ",", "and", "enterolactone", "(", "C1334513#ent", "<e2>", ")", "on", "gap", "junctional", "intercellular", "communication", "GJIC", ")", "in", "HaCaT", "cells", "."], "h": {"id": "C0010209", "name": "C0010209#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334513", "name": "C1334513#ent", "pos": [23, 24]}}
{"token": ["Mutations", "of", "the", "ATM", "and", "C1334862#ent", "<e1>", "responsible", "for", "the", "inherited", "Ataxia-Telangiectasia", "and", "C0398791#ent", "<e2>", "both", "of", "which", "are", "associated", "with", "predisposition", "to", "cancer", "."], "h": {"id": "C1334862", "name": "C1334862#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0398791", "name": "C0398791#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "knockdown", "of", "BIG1", "and", "C1413562#ent", "<e1>", "caused", "loss", "of", "clathrin", "C1332163#ent", "<e2>", "redistribution", "of", "several", "TGN", "markers", ",", "but", "had", "no", "impact", "on", "COPI", "and", "several", "Golgi", "markers", "."], "h": {"id": "C1413562", "name": "C1413562#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332163", "name": "C1332163#ent", "pos": [13, 14]}}
{"token": ["Deletion", "of", "the", "C0796520#ent", "<e1>", "HLH", "domain", "abolished", "dimer", "formation", "either", "C0796520#ent", "<e1>", "or", "C3274722#ent", "<e1>", ",", "and", "cells", "expressing", "this", "mutant", "protein", "morphologically", "non-transformed", "and", "failed", "to", "grow", "in", "soft", "agar"], "h": {"id": "C0796520", "name": "C0796520#ent", "pos": [3, 4]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274722", "name": "C3274722#ent", "pos": [14, 15]}}
{"token": ["Ambulant", "patients", "with", "recently", "diagnosed", "generalised", "or", "C0014556#ent", "<e1>", "both", "were", "randomly", "assigned", "to", "two", "dosage", "regimens", "of", "C0031507#ent", "<e2>", "."], "h": {"id": "C0014556", "name": "C0014556#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [18, 19]}}
{"token": ["Trimethoprim-sulphamethoxazole", "(", "TMP-SMZ", ")", "is", "considered", "a", "safe", "C0013227#ent", "<e1>", "for", "treatment", "of", "infectious", "C0162627#ent", "<e2>", "children", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162627", "name": "C0162627#ent", "pos": [14, 15]}}
{"token": ["This", "paper", "is", "a", "report", "of", "a", "study", "to", "examine", "the", "effect", "of", "Nei-Guan", "point", "acupressure", "on", "nausea", ",", "vomiting", "and", "C0162275#ent", "<e1>", "levels", "in", "women", "diagnosed", "with", "C0020450#ent", "<e2>"], "h": {"id": "C0162275", "name": "C0162275#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0020450", "name": "C0020450#ent", "pos": [28, 29]}}
{"token": ["However", ",", "a", "better", "preservation", "was", "obtained", "in", "the", "presence", "of", "selective", "C0003015#ent", "<e1>", "heparin", "(", "100", "microg/ml", ")", "or", "C0597217#ent", "<e2>", "I2", ";", "100", "nM", ")", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0597217", "name": "C0597217#ent", "pos": [20, 21]}}
{"token": ["Subsequently", ",", "the", "use", "of", "the", "C0012695#ent", "<e1>", "lead", "mobilization", "test", "confirmed", "that", "C0018099#ent", "<e2>", "in", "the", "presence", "of", "chronic", "renal", "failure", "a", "useful", "marker", "of", "chronic", "lead", "intoxication"], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [13, 14]}}
{"token": ["SIADH", "may", "result", "from", "a", "variety", "of", "diseases", ",", "as", "well", "as", "from", "the", "use", "of", "drugs", "such", "as", "chlorpropamide", ",", "C0006949#ent", "<e1>", ",", "diuretics", ",", "and", "some", "C0003392#ent", "<e2>"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [28, 29]}}
{"token": ["The", "reading", "frames", "two", "pairs", "of", "C1417679#ent", "<e1>", "overlapped", ":", "ATPase", "8", "6", "and", "C1537993#ent", "<e2>", "and", "ND4", "by", "ten", "and", "seven", "nucleotides", ",", "respectively", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1537993", "name": "C1537993#ent", "pos": [14, 15]}}
{"token": ["Six", "C4083008#ent", "<e1>", "patients", "who", "had", "antecedent", "symptoms", "of", "C0581381#ent", "<e2>", "IgA", "anti-GM1", "antibodies", "."], "h": {"id": "C4083008", "name": "C4083008#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [9, 10]}}
{"token": ["In", "conclusion", ",", "the", "addition", "of", "spironolactone", "or", "C0025859#ent", "<e1>", "to", "a", "conventional", "treatment", "C0018801#ent", "<e2>", "patients", "resulted", "in", "improved", "clinical", "conditions", "and", "the", "significant", "decrease", "in", "sudden", "death", "predictors", "corrected", "QT", "dispersion", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [14, 15]}}
{"token": ["Two", "patients", ",", "both", "seropositive", "for", "the", "C3854222#ent", "<e1>", "developed", "rapidly", "progressive", "C0035319#ent", "<e2>", "associated", "with", "systemic", "herpes", "zoster", "infection"], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035319", "name": "C0035319#ent", "pos": [12, 13]}}
{"token": ["The", "other", "three", "groups", "received", "C1423571#ent", "<e1>", "supplementation", "to", "increase", "C1423571#ent", "<e1>", "to", "50", "%", "of", "C0815040#ent", "<e1>", "compared", "to", "21.5", "%", "C1423571#ent", "<e1>", "content", "in", "whey", "protein"], "h": {"id": "C1423571", "name": "C1423571#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [16, 17]}}
{"token": ["Myristic", "acid", "stimulated", "C1412128#ent", "<e1>", "a", "synergistic", "action", "observed", "with", "C0011777#ent", "<e2>", "."], "h": {"id": "C1412128", "name": "C1412128#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}}
{"token": ["Compared", "with", "the", "C1420006#ent", "<e1>", "formulation", ",", "the", "tablet", "formulation", "in", "more", "consistent", "C0674432#ent", "<e2>", "and", "ritonavir", "exposures", "within", "and", "across", "studies", "and", "across", "meal", "conditions"], "h": {"id": "C1420006", "name": "C1420006#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0674432", "name": "C0674432#ent", "pos": [13, 14]}}
{"token": ["The", "host", "response", "to", "Gram-negative", "C0004623#ent", "<e1>", "influenced", "by", "two", "homologous", "lipopolysaccharide", "(LPS)-interactive", "proteins", ",", "LPS-binding", "protein", "C1414322#ent", "<e2>", ")", "and", "the", "bacteridical/permeability-increasing", "protein", "BPI", ")", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414322", "name": "C1414322#ent", "pos": [17, 18]}}
{"token": ["C0035369#ent", "<e1>", "insertion", "mutagenesis", "considered", "a", "powerful", "tool", "to", "identify", "C0919437#ent", "<e2>", "mice", ",", "but", "its", "significance", "for", "human", "cancer", "remained", "elusive", "."], "h": {"id": "C0035369", "name": "C0035369#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919437", "name": "C0919437#ent", "pos": [10, 11]}}
{"token": ["The", "placenta", "was", "impermeable", "to", "C1705225#ent", "<e1>", ",", "TSH", "and", "C1418938#ent", "<e2>", "in", "both", "directions", "."], "h": {"id": "C1705225", "name": "C1705225#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [10, 11]}}
{"token": ["CRSPs", "34", ",", "77", "and", "130", "are", "new", "proteins", ",", "but", "the", "amino", "terminus", "of", "C1332785#ent", "<e1>", "is", "homologous", "to", "elongation", "factor", "C3273646#ent", "<e2>", "."], "h": {"id": "C1332785", "name": "C1332785#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3273646", "name": "C3273646#ent", "pos": [22, 23]}}
{"token": ["A", "CCAAT/enhancer-binding", "protein", "C/EBP", ")", "binding", "site", "located", "at", "+", "22", "to", "+", "30", "was", "bound", "by", "C1413947#ent", "<e1>", "a", "TPA-dependent", "manner", "and", "was", "solely", "responsible", "for", "the", "C0078956#ent", "<e2>", "responsiveness", "."], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [28, 29]}}
{"token": ["We", "used", "transgenic", "(", "TG", ")", "mice", "overexpressing", "human", "C0072296#ent", "<e1>", "examine", "the", "effect", "of", "C0001622#ent", "<e2>", "of", "PGD(2", ")", "in", "an", "OVA-induced", "murine", "asthma", "model"], "h": {"id": "C0072296", "name": "C0072296#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [15, 16]}}
{"token": ["Fetal", "rat", "skeletal", "muscles", "express", "a", "troponin", "T", "C2240312#ent", "<e1>", ")", "C0597298#ent", "<e2>", "similar", "to", "the", "C2240312#ent", "<e1>", "C0597298#ent", "<e2>", "expressed", "in", "the", "embryonic", "heart", "respect", "to", "electrophoretic", "mobility", "immunoreactivity", "with", "cardiac", "TnT-specific", "monoclonal", "antibodies", "."], "h": {"id": "C2240312", "name": "C2240312#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}}
{"token": ["The", "early", "recognition", "C0037822#ent", "<e1>", "liver", "transplant", "recipients", "that", "receive", "C0010592#ent", "<e2>", "should", "prompt", "withdrawal", "of", "the", "drug", "to", "avoid", "possible", "neurological", "sequelae"], "h": {"id": "C0037822", "name": "C0037822#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [10, 11]}}
{"token": ["Estimates", "of", "the", "apical", "membrane", "partial", "Na", "and", "K", "conductances", "(", "C0216660#ent", "<e1>", "and", "GaK", ")", "and", "of", "ion", "currents", "IaNa", "and", "C0673827#ent", "<e2>", ")", "also", "demonstrated", "stimulation", "by", "the", "high", "K", "diet"], "h": {"id": "C0216660", "name": "C0216660#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0673827", "name": "C0673827#ent", "pos": [22, 23]}}
{"token": ["Among", "the", "protease", "inhibitors", "only", "two", ",", "diprotin-A", "and", "C0031493#ent", "<e1>", "PMSA", ")", ",", "could", "inhibit", "C1366487#ent", "<e2>", "activity", "."], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366487", "name": "C1366487#ent", "pos": [16, 17]}}
{"token": ["Follistatin-related", "gene", "C1708026#ent", "<e1>", ")", "is", "a", "member", "of", "the", "follistatin", "family", "of", "C0086376#ent", "<e2>", "and", "interacts", "with", "transforming", "growth", "factor", "TGF", ")", "superfamily", "proteins", "follistatin", "."], "h": {"id": "C1708026", "name": "C1708026#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["It", "is", "conceivable", "that", "in", "part", "the", "pathogenesis", "of", "C0030360#ent", "<e1>", "entails", "defects", "in", "the", "C3494348#ent", "<e2>", "aCL", "antibodies"], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [15, 16]}}
{"token": ["A", "case", "of", "carbon", "monoxide", "CO", ")", "poisoning", "with", "severe", "myonecrosis", "and", "C0022660#ent", "<e1>", "ARF", ")", "is", "presented", "with", "extremely", "high", "values", "of", "C1418571#ent", "<e2>", "but", "with", "preservation", "of", "myocardial", "tissue"], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418571", "name": "C1418571#ent", "pos": [23, 24]}}
{"token": ["These", "observations", "and", "the", "known", "activity", "of", "C1421933#ent", "<e1>", "-", "1", "suggest", "biological", "functions", "are", "not", "shared", "with", "other", "C1865138#ent", "<e2>", "."], "h": {"id": "C1421933", "name": "C1421933#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [19, 20]}}
{"token": ["A", "new", "spectrophotometric", "assay", "developed", "that", "allows", "the", "rapid", "determination", "of", "SPG-R", "activity", "and", "specific", "measurement", "of", "C1421933#ent", "<e1>", "-", "1", "in", "the", "presence", "of", "other", "C1865138#ent", "<e2>", "."], "h": {"id": "C1421933", "name": "C1421933#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [26, 27]}}
{"token": ["The", "available", "data", "show", "that", "the", "SPG-R", "reaction", "is", "catalyzed", "by", "C1421933#ent", "<e1>", "-", "1", "and", "not", "by", "other", "C1865138#ent", "<e2>", ",", "including", "the", "closely", "related", "GSTO2", "-", "2", "isoenzyme", "."], "h": {"id": "C1421933", "name": "C1421933#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [19, 20]}}
{"token": ["The", "high", "incidence", "of", "concurrent", "C0221423#ent", "<e1>", "known", "to", "induce", "C0030305#ent", "<e2>", "makes", "a", "trigger", "role", "or", "co-factor", "role", "for", "the", "drug", "seem", "most", "likely", "."], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [10, 11]}}
{"token": ["These", "findings", "demonstrate", "basal", "state", "binding", "of", "C1705556#ent", "<e1>", "to", "the", "C1561643#ent", "<e2>", "leading", "to", "cis-autophosphorylation", "and", "novel", "basal", "state", "interactions", "among", "the", "subdomains", "of", "the", "insulin", "receptor", "kinase"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [11, 12]}}
{"token": ["Matrix", "metalloproteinase-1", "C0166027#ent", "<e1>", ")", "breaks", "down", "C0127082#ent", "<e2>", "a", "major", "component", "of", "stromal", "tissue", "a", "barrier", "for", "invading", "tumor", "cells", "."], "h": {"id": "C0166027", "name": "C0166027#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [7, 8]}}
{"token": ["Fibroblast", "collagenase", "C0166027#ent", "<e1>", ")", ",", "a", "member", "of", "the", "C0127082#ent", "<e2>", "is", "believed", "to", "be", "a", "pathogenesis", "of", "arthritis", ",", "by", "cleaving", "triple-helical", "type", "II", "collagen", "in", "cartilage", "."], "h": {"id": "C0166027", "name": "C0166027#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [10, 11]}}
{"token": ["Unexpectedly", ",", "the", "high", "prevalence", "of", "these", "common", "parasites", "was", "not", "accompanied", "by", "elevated", "C3812635#ent", "<e1>", "values", ",", "which", "suggests", "the", "existence", "of", "moderate", "C0851341#ent", "<e2>", "."], "h": {"id": "C3812635", "name": "C3812635#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0851341", "name": "C0851341#ent", "pos": [24, 25]}}
{"token": ["The", "C3812293#ent", "<e1>", "activity", "was", "decreased", "in", "lipid-depleted", "microsomes", ",", "and", "the", "C0014442#ent", "<e2>", "was", "not", "reactivated", "when", "phosphatidylcholine-lysophosphatidylcholine", "liposomes", "were", "added", "at", "a", "low", "temperature", "."], "h": {"id": "C3812293", "name": "C3812293#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["The", "second", "was", "to", "investigate", "line", "and", "diet", "effects", "hepatic", "glutathione-S-epoxytransferase", "(", "GST", ")", "and", "uridine", "diphosphate", "glucuronosyl-transferase", "C3812293#ent", "<e1>", ")", "activities", "and", "to", "relate", "C0014442#ent", "<e2>", "activities", "to", "reproduction", "within", "line", "by", "diet", "groups"], "h": {"id": "C3812293", "name": "C3812293#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [25, 26]}}
{"token": ["Base", "excision", "repair", "not", "important", "since", "RE", "is", "approximately", "0.3", "in", "strains", "deficient", "in", "3-methyladenine", "DNA", "glycosylases", "I", "II", ",", "C0118120#ent", "<e1>", "both", "known", "C1506647#ent", "<e2>", "or", "DNA", "deoxyribophosphodiesterase"], "h": {"id": "C0118120", "name": "C0118120#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1506647", "name": "C1506647#ent", "pos": [24, 25]}}
{"token": ["Methyl", "alpha-D-mannoside", "C0089267#ent", "<e1>", "were", "also", "competitive", "inhibitors", "of", "C1421114#ent", "<e2>", "and", "competed", "with", "each", "other", "for", "the", "same", "site", "."], "h": {"id": "C0089267", "name": "C0089267#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [9, 10]}}
{"token": ["Single", "fibre", "electromyography", "carried", "out", "in", "patients", "with", "C0152025#ent", "<e1>", "due", "to", "C0042749#ent", "<e2>", ",", "diabetes", ",", "and", "alcohol", "."], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042749", "name": "C0042749#ent", "pos": [12, 13]}}
{"token": ["We", "studied", "30", "families", "with", "C0017668#ent", "<e1>", "and", "apparent", "C3899988#ent", "<e2>", "inheritance", "and", "91", "individuals", "with", "primary", "FSGS"], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [9, 10]}}
{"token": ["We", "earlier", "isolated", "cDNAs", "encoding", "novel", "human", "protein", "kinases", "C1420466#ent", "<e1>", "and", "AIK2", "sharing", "high", "amino", "acid", "identities", "with", "Drosophila", "C0971285#ent", "<e2>", "and", "Saccharomyces", "cerevisiae", "Ipl1", "kinases", "whose", "mutations", "cause", "abnormal", "chromosome", "segregation"], "h": {"id": "C1420466", "name": "C1420466#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0971285", "name": "C0971285#ent", "pos": [20, 21]}}
{"token": ["The", "effects", "of", "three", "calcium", "antagonists", "nifedipine", "(", "NF", ")", ",", "verapamil", "(", "V", ")", "and", "C0012373#ent", "<e1>", "(", "DL", ")", ",", "on", "rat", "C3850038#ent", "<e2>", "studied", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3850038", "name": "C3850038#ent", "pos": [24, 25]}}
{"token": ["The", "results", "of", "the", "present", "study", "showed", "that", "the", "substitution", "for", "C1367702#ent", "<e1>", "not", "affect", "the", "C1512412#ent", "<e2>", "Pien", "Tze", "Huang"], "h": {"id": "C1367702", "name": "C1367702#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1512412", "name": "C1512412#ent", "pos": [16, 17]}}
{"token": ["Three-dimensional", "structures", "several", "transport", "intermediates", "of", "C1421250#ent", "<e1>", ",", "stabilized", "by", "structural", "analogues", "of", "C1705556#ent", "<e2>", "and", "phosphoryl", "groups", ",", "are", "now", "available", "at", "atomic", "resolution", "."], "h": {"id": "C1421250", "name": "C1421250#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [14, 15]}}
{"token": ["The", "activities", "of", "these", "5'LS", "C1849718#ent", "<e1>", "were", "modulated", "by", "C2936882#ent", "<e2>", "in", "an", "inverse", "manner", "to", "AT1", "receptor", "regulation"], "h": {"id": "C1849718", "name": "C1849718#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [10, 11]}}
{"token": ["The", "methodology", "is", "illustrated", "with", "data", "from", "a", "study", "that", "assessed", "the", "probability", "of", "C0003742#ent", "<e1>", "patients", "with", "C0745103#ent", "<e2>"], "h": {"id": "C0003742", "name": "C0003742#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0745103", "name": "C0745103#ent", "pos": [18, 19]}}
{"token": ["C3274826#ent", "<e1>", "and", "fishery", "products", "considered", "as", "the", "main", "source", "of", "organotin", "compounds", "C1418193#ent", "<e2>", ")", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418193", "name": "C1418193#ent", "pos": [13, 14]}}
{"token": ["In", "the", "present", "study", "we", "have", "introduced", "mutations", "in", "the", "SA", "domain", "neprilysin", "(", "neutral", "endopeptidase-24.11", ";", "C1366499#ent", "<e1>", ")", "to", "identify", "structural", "elements", "would", "favour", "the", "processing", "of", "C1825840#ent", "<e2>", "domains", "by", "signal", "peptidase"], "h": {"id": "C1366499", "name": "C1366499#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [29, 30]}}
{"token": ["CLE0", "is", "also", "the", "main", "target", "for", "IL-5", "inhibition", "by", "C0011777#ent", "<e1>", ",", "and", "we", "present", "evidence", "consistent", "with", "role", "of", "C3539618#ent", "<e2>", "in", "this", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539618", "name": "C3539618#ent", "pos": [21, 22]}}
{"token": ["However", ",", "in", "both", "strains", "C0751039#ent", "<e1>", "administration", "was", "associated", "with", "similar", "C1705296#ent", "<e2>", "increase", "which", "was", "not", "prevented", "by", "omega-3", "fatty", "acids", "EPAX", ")", "or", "vitamin", "E", "administration", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705296", "name": "C1705296#ent", "pos": [12, 13]}}
{"token": ["In", "addition", "to", "providing", "superior", "symptom", "control", ",", "C0085173#ent", "<e1>", "caused", "less", "drowsiness", "and", "fatigue", "than", "C0008281#ent", "<e2>", "."], "h": {"id": "C0085173", "name": "C0085173#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008281", "name": "C0008281#ent", "pos": [16, 17]}}
{"token": ["Astemizole", "was", "superior", "to", "placebo", "and", "the", "classical", "antihistamines", "Clemastine", ",", "C0085173#ent", "<e1>", ",", "Ketotifen", ",", "Mequitazine", ",", "pheniramine", "and", "C0008281#ent", "<e2>", "."], "h": {"id": "C0085173", "name": "C0085173#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008281", "name": "C0008281#ent", "pos": [20, 21]}}
{"token": ["Mutations", "in", "C1420348#ent", "<e1>", "causing", "autosomal", "dominant", "pure", "C0037772#ent", "<e2>", "to", "identification", "of", "atlastin", ",", "a", "new", "dynamin-like", "large", "GTPase"], "h": {"id": "C1420348", "name": "C1420348#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037772", "name": "C0037772#ent", "pos": [8, 9]}}
{"token": ["Dominant", "C0029124#ent", "<e1>", "C0338508#ent", "<e2>", "is", "an", "autosomal", "dominant", "eye", "disease", "is", "characterized", "by", "progressive", "C0029124#ent", "<e1>", "onset", "in", "early", "childhood", "decrease", "of", "visual", "acuity", "colour", "vision", "defects", "centrocecal", "scotoma"], "h": {"id": "C0338508", "name": "C0338508#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [1, 2]}}
{"token": ["C0338508#ent", "<e1>", "ADOA", ")", "is", "the", "most", "common", "form", "of", "inherited", "C0029124#ent", "<e2>"], "h": {"id": "C0338508", "name": "C0338508#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [11, 12]}}
{"token": ["The", "contributing", "causes", "of", "poor", "housing", "overcrowding", "and", "poor", "nutrition", "coupled", "with", "the", "debilitating", "effect", "of", "recent", "epidemics", "of", "C0042769#ent", "<e1>", "measles", ",", "mumps", "and", "C0035920#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [19, 20]}, "relation": "related_to", "t": {"id": "C0035920", "name": "C0035920#ent", "pos": [25, 26]}}
{"token": ["Immune", "thrombocytopenic", "purpura", "an", "infrequent", "yet", "well-recognized", "complication", "of", "C0042769#ent", "<e1>", "such", "as", "mumps", ",", "C0035920#ent", "<e2>", ",", "varicella", ",", "cytomegalovirus", ",", "parvovirus", "and", "infectious", "monunucleosis", "Epstein-Barr", "virus"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0035920", "name": "C0035920#ent", "pos": [15, 16]}}
{"token": ["C0406217#ent", "<e1>", "differentiated", "from", "C0031736#ent", "<e2>", "childhood", "onset", "more", "persistent", "and", "excoriated", "lesions", "present", "both", "on", "sun-exposed", "and", ",", "to", "a", "lesser", "extent", ",", "non-exposed", "sites", "."], "h": {"id": "C0406217", "name": "C0406217#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031736", "name": "C0031736#ent", "pos": [4, 5]}}
{"token": ["These", "HLA", "associations", "may", "be", "helpful", "in", "determining", "whether", "C0406217#ent", "<e1>", "a", "distinct", "disease", "or", "a", "variant", "of", "C0031736#ent", "<e2>"], "h": {"id": "C0406217", "name": "C0406217#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031736", "name": "C0031736#ent", "pos": [18, 19]}}
{"token": ["SANDOZ", "9785", ",", "also", "known", "as", "C0001752#ent", "<e1>", "13.338", ",", "is", "a", "pyridazinone", "derivative", "that", "inhibits", "Photosystem", "II", "C3273406#ent", "<e2>", "activity", "leading", "to", "an", "imbalance", "in", "the", "rate", "of", "electron", "transport", "the", "photosystems", "."], "h": {"id": "C0001752", "name": "C0001752#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [18, 19]}}
{"token": ["A", "study", "was", "carried", "out", "on", "serum", "from", "240", "patients", ",", "including", "23", "patients", "with", "Wegener's", "granulomatosis", "12", "with", "C2347126#ent", "<e1>", "and", "30", "with", "various", "C0009782#ent", "<e2>"], "h": {"id": "C2347126", "name": "C2347126#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [25, 26]}}
{"token": ["The", "authors", "report", "on", "a", "boy", "with", "Ullrich", "disease", "has", "complete", "deficiency", "of", "C0009325#ent", "<e1>", "harbors", "compound", "heterozygous", "mutations", "in", "the", "C1333079#ent", "<e2>"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333079", "name": "C1333079#ent", "pos": [21, 22]}}
{"token": ["We", "report", "the", "case", "of", "a", "42-day-old", "boy", "who", "presented", "with", "C0521800#ent", "<e1>", "after", "receiving", "local", "anesthesia", "C0033124#ent", "<e2>", "."], "h": {"id": "C0521800", "name": "C0521800#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033124", "name": "C0033124#ent", "pos": [17, 18]}}
{"token": ["4", "C3539947#ent", "<e1>", "KKKL", ",", "but", "not", "KKL", ")", "on", "the", "C1366631#ent", "<e2>", "were", "clarified", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1366631", "name": "C1366631#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C1096902#ent", "<e1>", "enters", "in", "the", "differential", "diagnosis", "hydrops", "fetalis", "a", "C0267971#ent", "<e2>", "phenotype", "."], "h": {"id": "C1096902", "name": "C1096902#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0267971", "name": "C0267971#ent", "pos": [12, 13]}}
{"token": ["Cells", "of", "the", "mononuclear", "and", "endothelial", "lineages", "targets", "for", "viruses", "which", "cause", "C0019104#ent", "<e1>", "HF", ")", "such", "as", "the", "filoviruses", "Marburg", "C0282687#ent", "<e2>", ",", "and", "the", "arenaviruses", "Lassa", "Junin", "."], "h": {"id": "C0019104", "name": "C0019104#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0282687", "name": "C0282687#ent", "pos": [21, 22]}}
{"token": ["It", "has", "been", "suggested", "that", "C0271889#ent", "<e1>", "regionalization", "partially", "depends", "on", "local", "signaling", "by", "sonic", "hedgehog", "C0672708#ent", "<e2>", ")", "."], "h": {"id": "C0271889", "name": "C0271889#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0672708", "name": "C0672708#ent", "pos": [16, 17]}}
{"token": ["A5", "cells", "were", "found", "to", "have", "higher", "levels", "of", "C0162508#ent", "<e1>", "mRNA", "than", "C0025250#ent", "<e2>", "during", "active", "cell", "growth", "after", "serum", "starvation"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [13, 14]}}
{"token": ["Injection", "of", "fgf17b", "mRNA", "into", "one-cell", "embryos", "induces", "expression", "of", "the", "mesodermal", "marker", "no", "tail", "(", "C1425400#ent", "<e1>", ")", "and", "rescues", "C1425400#ent", "<e1>", "expression", "suppressed", "by", "overexpression", "of", "C1537560#ent", "<e1>", "(", "lft1", ")", "."], "h": {"id": "C1425400", "name": "C1425400#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1537560", "name": "C1537560#ent", "pos": [28, 29]}}
{"token": ["In", "spite", "of", "the", "fact", "that", "C0026896#ent", "<e1>", "usually", "mentioned", "in", "the", "differential", "diagnosis", "C0042454#ent", "<e2>", "it", "is", "rarely", "ruled", "out", "by", "specific", "studies", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042454", "name": "C0042454#ent", "pos": [14, 15]}}
{"token": ["C1416546#ent", "<e1>", "associated", "with", "TAP1", "in", "the", "absence", "of", "tapasin", "or", "C1336576#ent", "<e2>", ",", "suggesting", "that", "TAP1", "was", "a", "primary", "binding", "in", "the", "peptide", "loading", "complex"], "h": {"id": "C1416546", "name": "C1416546#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336576", "name": "C1336576#ent", "pos": [11, 12]}}
{"token": ["Reciprocally", ",", "UDP", ",", "the", "selective", "C1418221#ent", "<e1>", "agonist", ",", "induced", "C1705592#ent", "<e2>", "release", "by", "monocytes", "."], "h": {"id": "C1418221", "name": "C1418221#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [11, 12]}}
{"token": ["Cyclin", "D1", "a", "C1415740#ent", "<e1>", "activates", "CDK4", "and", "C1565313#ent", "<e2>", ",", "titrates", "Cip/Kip", "CDK", "inhibitors", "to", "increase", "CDK2", "activity", ",", "and", "modulates", "the", "function", "of", "certain", "transcription", "factors"], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565313", "name": "C1565313#ent", "pos": [8, 9]}}
{"token": ["Blockade", "of", "Kir", "with", "100", "microM", "BaCl(2", ")", "significantly", "depolarized", "the", "C3272713#ent", "<e1>", "to", "-30", "mV", ";", "the", "C3272713#ent", "<e1>", "was", "unaffected", "by", "TEA", "or", "C0035064#ent", "<e1>", "that", "modulated", "ATP-sensitive", "potassium", "channels"], "h": {"id": "C3272713", "name": "C3272713#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [25, 26]}}
{"token": ["The", "C3272713#ent", "<e1>", "was", "unaffected", "by", "C0035064#ent", "<e2>", "that", "modulated", "ATP-sensitive", "potassium", "channels"], "h": {"id": "C3272713", "name": "C3272713#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [6, 7]}}
{"token": ["Components", "of", "the", "L-arginine", "metabolic", "pathway", ",", "especially", "inducible", "nitric", "oxide", "NO", ")", "synthase", "(", "iNOS", ")", ",", "ornithine", "aminotransferase", "OAT", ")", ",", "and", "ornithine", "decarboxylase", "C1422630#ent", "<e1>", ")", ",", "have", "been", "associated", "with", "C0268731#ent", "<e2>"], "h": {"id": "C1422630", "name": "C1422630#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [34, 35]}}
{"token": ["The", "reaction", "was", "completely", "inhibited", "by", "C0038838#ent", "<e1>", "by", "4,4'-diisothiocyano-2,2'-disulfonic", "acid", "a", "specific", "C0001645#ent", "<e2>", "of", "anion", "channels", "membranes", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [13, 14]}}
{"token": ["Although", "it", "is", "seen", "infrequently", ",", "it", "must", "be", "considered", "in", "patients", "with", "sore", "throat", "dental", "pain", "C0007859#ent", "<e1>", "sepsis", ",", "and", "C1457887#ent", "<e2>"], "h": {"id": "C0007859", "name": "C0007859#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [22, 23]}}
{"token": ["We", "found", "that", "variant", "genotypes", "of", "C0919427#ent", "<e1>", "and", "DHFR", "C1417679#ent", "<e2>", "were", "associated", "with", "increased", "BC", "risk", "among", "premenopausal", "women", "polymorphism", "in", "IL-18", ",", "p53", "genes", "associated", "with", "BC", "among", "postmenopausal", "women", "."], "h": {"id": "C0919427", "name": "C0919427#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["Furthermore", "C3814041#ent", "<e1>", "and", "IL-21iso", "similarly", "activated", "C1335872#ent", "<e2>", "and", "STAT3", "."], "h": {"id": "C3814041", "name": "C3814041#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335872", "name": "C1335872#ent", "pos": [7, 8]}}
{"token": ["HISTORY", "AND", "SYMPTOMS", ":", "For", "11", "weeks", "a", "38-year-old", "woman", "had", "suffered", "from", "a", "C0035243#ent", "<e1>", "peribronchitis", ",", "nocturnal", "coughing", "and", "C0013456#ent", "<e2>", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013456", "name": "C0013456#ent", "pos": [21, 22]}}
{"token": ["After", "the", "menopause", "there", "is", "a", "profound", "increase", "in", "cardiovascular", "diseases", "is", "mainly", "based", "on", "an", "enhanced", "development", "of", "C0003850#ent", "<e1>", "caused", "by", "an", "C0342527#ent", "<e2>"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0342527", "name": "C0342527#ent", "pos": [24, 25]}}
{"token": ["The", "activity", "of", "deoxyhypusine", "synthase", "the", "first", "enzyme", "in", "the", "formation", "of", "active", "C1414360#ent", "<e1>", ",", "was", "inhibited", "by", "C0284559#ent", "<e2>", "in", "a", "cell-free", "system"], "h": {"id": "C1414360", "name": "C1414360#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0284559", "name": "C0284559#ent", "pos": [19, 20]}}
{"token": ["These", "results", ",", "taken", "together", ",", "indicate", "that", "inhibition", "of", "active", "C1414360#ent", "<e1>", "formation", "is", "strongly", "involved", "in", "the", "inhibition", "of", "cell", "growth", "C0284559#ent", "<e2>", "."], "h": {"id": "C1414360", "name": "C1414360#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0284559", "name": "C0284559#ent", "pos": [23, 24]}}
{"token": ["These", "findings", "indicate", "that", "the", "C0026847#ent", "<e1>", "is", "one", "of", "the", "bioproducts", "of", "acute", "rheumatic", "fever", "C0035439#ent", "<e2>", "but", "the", "immunopathogenetic", "role", "of", "C0026847#ent", "<e1>", "in", "these", "particular", "disease", "still", "needs", "further", "investigation", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035439", "name": "C0035439#ent", "pos": [16, 17]}}
{"token": ["Our", "data", "indicate", "a", "complex", "pattern", "of", "C1839729#ent", "<e1>", "in", "this", "species", "and", "suggest", "that", "the", "two", "C1875400#ent", "<e2>", "differ", "in", "their", "relative", "sensitivities", "to", "agonists", "targeting", "different", "C1839729#ent", "<e1>", "."], "h": {"id": "C1839729", "name": "C1839729#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [17, 18]}}
{"token": ["This", "investigation", "tested", "the", "hypotheses", "that", "C0012772#ent", "<e1>", "prevents", "halothane-dependent", "protein", "trifluoroacetylation", "in", "vivo", "and", "that", "C1705607#ent", "<e2>", "represents", "a", "biomarker", "for", "hepatic", "protein", "trifluoroacetylation", "."], "h": {"id": "C0012772", "name": "C0012772#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705607", "name": "C1705607#ent", "pos": [16, 17]}}
{"token": ["Both", "subclasses", "of", "C0067533#ent", "<e1>", "exhibited", "variation", "in", "apparent", "Mr", "on", "C0272170#ent", "<e2>", "gels", "."], "h": {"id": "C0067533", "name": "C0067533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [11, 12]}}
{"token": ["The", "muscle", "form", "has", "been", "named", "phosphoglycerate", "kinase-1", "A.", "The", "only", "previously", "known", "isozyme", "is", "the", "testis", "enzyme", "phosphoglycerate", "kinase-2", "B.", "We", "therefore", "propose", "that", "the", "C0014442#ent", "<e1>", "known", "as", "C0031656#ent", "<e2>", "C."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0031656", "name": "C0031656#ent", "pos": [30, 31]}}
{"token": ["This", "finding", "supports", "the", "hypothesis", "that", "C0162770#ent", "<e1>", "be", "due", "to", "C0342527#ent", "<e2>", "the", "critical", "period", "of", "organogenesis", "."], "h": {"id": "C0162770", "name": "C0162770#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0342527", "name": "C0342527#ent", "pos": [11, 12]}}
{"token": ["Report", "of", "a", "patient", "with", "the", "hydrocephalic", "and", "meningoencephalitic", "form", "neurocysticercosis", "who", "simultaneously", "developed", "polyradiculoneuropathy", "and", "C0151740#ent", "<e1>", "the", "first", "week", "of", "treatment", "with", "C0001911#ent", "<e2>", "."], "h": {"id": "C0151740", "name": "C0151740#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001911", "name": "C0001911#ent", "pos": [24, 25]}}
{"token": ["Mortalin", ",", "a", "member", "of", "the", "heat", "shock", "protein", "family", "HSP70", ",", "was", "identified", "by", "C1425522#ent", "<e1>", "as", "a", "putative", "C1332807#ent", "<e2>", "substrate", "."], "h": {"id": "C1425522", "name": "C1425522#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [20, 21]}}
{"token": ["Axillary", "compounds", "collected", "from", "donor", "women", "the", "follicular", "phase", "FP", ")", "and", "the", "ovulatory", "phase", "C0338271#ent", "<e1>", ")", "and", "were", "treated", "with", "C0022237#ent", "<e2>", "IPA", ")", "."], "h": {"id": "C0338271", "name": "C0338271#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022237", "name": "C0022237#ent", "pos": [22, 23]}}
{"token": ["Clenbuterol", "[", "CLE", ":", "4-amino-alpha(t-butyl-amino)methyl-3,5-dichlorobenzyl", "C0001975#ent", "<e1>", "]", "is", "well", "known", "as", "a", "potent", "C2917450#ent", "<e2>", "non-steroidal", "anabolic", "drug", "and", "thus", "it", "is", "generally", "used", "for", "sports", "doping", "and", "asthma", "therapy"], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2917450", "name": "C2917450#ent", "pos": [14, 15]}}
{"token": ["Factor", "IX", "FIX", ")", "deficiency", "results", "in", "C0008533#ent", "<e1>", "high", "dose", "recombinant", "activated", "factor", "VII", "(", "C0534191#ent", "<e2>", ")", "can", "decrease", "bleeding", "."], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0534191", "name": "C0534191#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "C0069178#ent", "<e1>", "has", "anti-allergic", "action", "inhibition", "of", "C0014457#ent", "<e2>", "accumulation", "in", "an", "antigen-challenged", "airway", "lesion", "in", "rats", "and", "guinea-pigs", "."], "h": {"id": "C0069178", "name": "C0069178#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [11, 12]}}
{"token": ["A", "simultaneous", "bilateral", "laparoscopic", "adrenalectomy", "performed", "in", "a", "patient", "in", "poor", "condition", "advanced", "C0010481#ent", "<e1>", "to", "adrenocorticotrophic", "hormone-independent", "macronodular", "adrenocortical", "hyperplasia", "(", "C1857451#ent", "<e2>", ")", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C1857451", "name": "C1857451#ent", "pos": [22, 23]}}
{"token": ["This", "case", "report", "a", "53-year", "old", "man", "C0010481#ent", "<e1>", "to", "Adrenocorticotropic", "Hormone", "ACTH", ")", "independent", "bilateral", "adrenocortical", "macronodular", "hyperplasia", "C1857451#ent", "<e2>", ")", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C1857451", "name": "C1857451#ent", "pos": [19, 20]}}
{"token": ["Five", "patients", "had", "manifestations", "of", "autoimmune", "disease", "including", "laboratory", "abnormalities", "positive", "antinuclear", "antibody", "positive", "latex", "agglutination", "rheumatoid", "factor", "C0020455#ent", "<e1>", "or", "antimitochondrial", "antibody", "in", "four", ",", "necrotizing", "vasculitis", "one", ",", "C0151445#ent", "<e2>", "phenomenon", "in", "two", "and", "clinical", "evidence", "multisystem", "collagen", "vascular", "disease", "two", "."], "h": {"id": "C0020455", "name": "C0020455#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0151445", "name": "C0151445#ent", "pos": [30, 31]}}
{"token": ["RanBP2", "associates", "in", "vitro", "in", "vivo", "colocalizes", "with", "the", "mitochondrial", "metallochaperone", "C0920270#ent", "<e1>", ",", "and", "the", "pacemaker", "of", "glycolysis", ",", "C0017713#ent", "<e2>", "HKI", ")", "via", "its", "leucine-rich", "domain"], "h": {"id": "C0920270", "name": "C0920270#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017713", "name": "C0017713#ent", "pos": [20, 21]}}
{"token": ["To", "assess", "the", "safety", "and", "efficacy", "of", "C0127615#ent", "<e1>", "preparations", "for", "therapy", "of", "C0860168#ent", "<e2>", "pregnancy", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0860168", "name": "C0860168#ent", "pos": [13, 14]}}
{"token": ["C0053071#ent", "<e1>", "0.5", "%", "lowered", "corneal", "sensitivity", "less", "than", "C0040233#ent", "<e2>", "0.5", "%", "."], "h": {"id": "C0053071", "name": "C0053071#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040233", "name": "C0040233#ent", "pos": [9, 10]}}
{"token": ["Assuming", "that", "Va", "and", "rac", "for", "C0053071#ent", "<e1>", "were", "also", "applicable", "for", "C0040233#ent", "<e2>", ",", "ka.ac", "for", "C0040233#ent", "<e2>", "was", "calculated", "to", "be", "0.25", "to", "0.29", "hr-1", "."], "h": {"id": "C0053071", "name": "C0053071#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040233", "name": "C0040233#ent", "pos": [12, 13]}}
{"token": ["The", "C0398791#ent", "<e1>", "NBS", ")", "results", "from", "mutations", "in", "the", "NBS1", "gene", "encodes", "C1334862#ent", "<e2>", ",", "and", "NBS", "cells", "radiosensitive", "and", "defective", "in", "S-phase", "checkpoint", "activation", "irradiation", "."], "h": {"id": "C0398791", "name": "C0398791#ent", "pos": [1, 2]}, "relation": "disease_has_associated_gene", "t": {"id": "C1334862", "name": "C1334862#ent", "pos": [13, 14]}}
{"token": ["We", "report", "a", "patient", "with", "C0019154#ent", "<e1>", "to", "obstruction", "of", "the", "inferior", "vena", "cava", "associated", "with", "C0009782#ent", "<e2>", "a", "circulating", "anticoagulant", "."], "h": {"id": "C0019154", "name": "C0019154#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [16, 17]}}
{"token": ["Drug", "can", "cause", "various", "types", "of", "lung", "damages", ",", "with", "drug-induced", "pneumonitis", "including", "C1279945#ent", "<e1>", "usual", "interstitial", "pneumonia", "desquamative", "interstitial", "pneumonia", "nonspecific", "interstitial", "pneumonia", "bronchiolitis", "obliterans", "C0242770#ent", "<e2>", "eosinophilic", "pneumonia", "hypersensitivity", "pneumonitis", "being", "the", "most", "important", "among", "them", "."], "h": {"id": "C1279945", "name": "C1279945#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242770", "name": "C0242770#ent", "pos": [26, 27]}}
{"token": ["Epistasis", "studies", "showed", "that", "deletion", "of", "MSS11", "abolishes", "the", "activation", "of", "STA2", "caused", "by", "the", "over-expression", "of", "C1419021#ent", "<e1>", ",", "a", "previously", "identified", "C0079429#ent", "<e2>", "."], "h": {"id": "C1419021", "name": "C1419021#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [23, 24]}}
{"token": ["In", "Drosophila", "the", "C0017337#ent", "<e1>", "responsible", "for", "specifying", "segment", "identity", "(", "the", "C1335843#ent", "<e2>", "are", "transcribed", "in", "complex", "patterns", "during", "development", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335843", "name": "C1335843#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "C0017337#ent", "<e1>", "have", "been", "identified", "that", "modify", "the", "functional", "specificity", "of", "C1335843#ent", "<e2>", "affecting", "their", "expression", "patterns", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335843", "name": "C1335843#ent", "pos": [14, 15]}}
{"token": ["Four", "hypertensive", "patients", "with", "chronic", "renal", "insufficiency", "C2316810#ent", "<e1>", "were", "treated", "with", "sustained-release", "verapamil", "C0546849#ent", "<e2>", "subsequently", "developed", "acute", "toxic", "effects"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [14, 15]}}
{"token": ["The", "incidence", "of", "PONV", "depends", "numerous", "factors", "including", "age", ",", "gender", ",", "obesity", ",", "anxiety", ",", "gastroparesis", ",", "history", "of", "C0721797#ent", "<e1>", "previous", "PONV", ",", "and", "the", "C2926735#ent", "<e2>", "and", "type", "of", "surgery"], "h": {"id": "C0721797", "name": "C0721797#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [27, 28]}}
{"token": ["Mitochondrial", "DNA", "mtDNA", ")", "variants", "associated", "with", "C2931257#ent", "<e1>", "AD", ")", "and", "Parkinson", "disease", "PD", ")", "were", "sought", "by", "C0012906#ent", "<e2>", "a", "cohort", "of", "71", "late-onset", "Caucasian", "patients", "."], "h": {"id": "C2931257", "name": "C2931257#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [19, 20]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "characterize", "the", "effect", "of", "a", "C0030193#ent", "<e1>", "stimulus", "on", "morphine", "and", "C0006491#ent", "<e2>", "effects", "in", "healthy", "non-drug", "abusing", "volunteers", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0006491", "name": "C0006491#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "C3273436#ent", "<e1>", "induced", "cyclin", "D1", "expression", "and", "stimulated", "C0246957#ent", "<e2>", "activity", "and", "cell", "cycle", "progression", "via", "the", "A-type", "receptor", "in", "rat", "mesangial", "cells"], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0246957", "name": "C0246957#ent", "pos": [10, 11]}}
{"token": ["Angiotensin", "II", "C3273406#ent", "<e1>", "has", "been", "implicated", "in", "the", "development", "of", "cardiovascular", "disorders", "C2316401#ent", "<e2>", "CKD", ")", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2316401", "name": "C2316401#ent", "pos": [13, 14]}}
{"token": ["Analysis", "of", "cerebrospinal", "fluid", "mononuclear", "cells", "from", "patients", "with", "C0026769#ent", "<e1>", "significantly", "higher", "mRNA", "expression", "of", "C3890185#ent", "<e2>", "compared", "with", "controls", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3890185", "name": "C3890185#ent", "pos": [16, 17]}}
{"token": ["C0040558#ent", "<e1>", "may", "respond", "to", "other", "antimicrobials", ",", "including", "macrolide", "antibiotics", "C1639494#ent", "<e2>", ",", "clinidamycin", ",", "and", "atovaquone", "."], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [11, 12]}}
{"token": ["Although", "C0030311#ent", "<e1>", "reduced", "the", "incidence", "of", "C0231528#ent", "<e2>", "by", "about", "50", "%", "overall", ",", "these", "values", "were", "not", "significantly", "different", "from", "each", "other", "."], "h": {"id": "C0030311", "name": "C0030311#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [7, 8]}}
{"token": ["C0663237#ent", "<e1>", "cDNA", "from", "rat", "brain", "library", "encodes", "a", "protein", "of", "1,248", "C3539946#ent", "<e2>", "a", "predicted", "Mr", "of", "138,268", "."], "h": {"id": "C0663237", "name": "C0663237#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "a", "central", "role", "for", "CtBP", "in", "C3274668#ent", "<e1>", "transcriptional", "repression", "implicate", "coordinated", "disruption", "of", "the", "C1335654#ent", "<e2>", "and", "GATAdevelopmental", "programs", "the", "pathogenesis", "of", "myelodysplasia", "."], "h": {"id": "C3274668", "name": "C3274668#ent", "pos": [9, 10]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [18, 19]}}
{"token": ["We", "found", "that", "both", "normal", "and", "mutant", "C1420276#ent", "<e1>", "specifically", "interact", "with", "the", "C0171406#ent", "<e2>", "cytochrome", "C", "oxidase", "COX", ")", "."], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [13, 14]}}
{"token": ["These", "results", "demonstrate", "the", "effects", "of", "C1420276#ent", "<e1>", "on", "proteasome", "and", "C0171406#ent", "<e2>", "gene", "expression", "provide", "further", "support", "for", "the", "role", "of", "these", "complexes", "in", "mediating", "neurotoxicity", "."], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [11, 12]}}
{"token": ["This", "sequence", "of", "events", "may", "be", "crucial", "in", "the", "pathophysiology", "of", "C0238074#ent", "<e1>", "and", "an", "exacerbating", "factor", "in", "other", "C0013604#ent", "<e2>"], "h": {"id": "C0238074", "name": "C0238074#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [19, 20]}}
{"token": ["On", "the", "basis", "of", "a", "small", "number", "of", "studies", ",", "C0238074#ent", "<e1>", "not", "caused", "by", "cardiac", "muscle", "failure", "at", "least", "in", "early", "C0013604#ent", "<e2>"], "h": {"id": "C0238074", "name": "C0238074#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [22, 23]}}
{"token": ["Both", "cathepsins", "D", "inactivated", "by", "C1418549#ent", "<e1>", "as", "pepstatin", ",", "1,2-epoxy-3-(p-nitrophenoxy)propane", ",", "C0048134#ent", "<e2>", "and", "diazoacetyl-DL-norleucine", "methyl", "ester", "although", "cathepsin", "D-II", "was", "much", "less", "susceptible", "to", "these", "reagents", "except", "C0048134#ent", "<e2>"], "h": {"id": "C1418549", "name": "C1418549#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0048134", "name": "C0048134#ent", "pos": [12, 13]}}
{"token": ["Occupational", "health", "hazards", "be", "associated", "with", "allergic", "contact", "dermatitis", "C0002873#ent", "<e1>", ")", "secondary", "to", "C1539312#ent", "<e2>", "exposure", "."], "h": {"id": "C0002873", "name": "C0002873#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [14, 15]}}
{"token": ["Most", "C0002873#ent", "<e1>", "occurs", "in", "workers", "handling", "C1539312#ent", "<e2>", "products", ",", "such", "as", "plastic-product", "workers", ",", "and", "those", "exposed", "to", "epoxy", "adhesive", "tapes", "foams", ",", "and", "dental", "products"], "h": {"id": "C0002873", "name": "C0002873#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [7, 8]}}
{"token": ["The", "C1419366#ent", "<e1>", "is", "highly", "C1334043#ent", "<e2>", "to", "that", "of", "the", "cyanobacterial", "PSI", "and", "maintains", "the", "position", "of", "most", "transmembrane", "helices", "chlorophylls", "during", "1.5", "years", "of", "separate", "evolution", "."], "h": {"id": "C1419366", "name": "C1419366#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}}
{"token": ["Until", "now", ",", "many", "of", "the", "C1332838#ent", "<e1>", "associated", "with", "AMD", "have", "been", "discovered", "using", "studies", "on", "C1516876#ent", "<e2>", "engineered", "and", "naturally", "mutated", "animals", ",", "linkage", "studies", "studies", "of", "monogenic", "degenerative", "retinal", "diseases", "association", "studies"], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [17, 18]}}
{"token": ["Analysis", "of", "the", "panels", "of", "cell", "lines", "indicates", "that", "C1425260#ent", "<e1>", ",", "similar", "to", "C1420251#ent", "<e2>", ",", "has", "a", "broad", "tissue", "distribution", "."], "h": {"id": "C1425260", "name": "C1425260#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420251", "name": "C1420251#ent", "pos": [14, 15]}}
{"token": ["C0770325#ent", "<e1>", "used", "to", "treat", "C0019202#ent", "<e2>", "chelating", "copper", "increasing", "its", "urinary", "excretion"], "h": {"id": "C0770325", "name": "C0770325#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [5, 6]}}
{"token": ["To", "compare", "tetrathiomolybdate", "and", "C0770325#ent", "<e1>", "in", "treating", "patients", "with", "the", "neurologic", "presentation", "C0019202#ent", "<e2>", "the", "frequency", "of", "neurologic", "worsening", "adverse", "effects", "and", "degree", "of", "neurologic", "recovery", "."], "h": {"id": "C0770325", "name": "C0770325#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [13, 14]}}
{"token": ["Data", "on", "efficacy", "and", "safety", "of", "angiotensin", "converting", "enzyme", "inhibitor", "C0066685#ent", "<e1>", "in", "the", "treatment", "of", "C0020538#ent", "<e2>", "reviewed", "."], "h": {"id": "C0066685", "name": "C0066685#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "a", "hypotensive", "effect", "and", "metabolic", "neutrality", "and", "safety", "of", "ACE", "inhibitor", "C0066685#ent", "<e1>", "in", "postmenopausal", "women", "with", "C0020538#ent", "<e2>", "AH", ")", ",", "influence", "on", "quality", "of", "life"], "h": {"id": "C0066685", "name": "C0066685#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [19, 20]}}
{"token": ["Three", "members", "of", "a", "family", "with", "dominantly", "inherited", "juvenile", "C0029124#ent", "<e1>", "tritan", "type", "colour", "vision", "deficiency", "showed", "dysfunction", "of", "the", "C1424852#ent", "<e2>", "mechanism", "tested", "with", "green", "light", "30", "min", "of", "dark", "adaptation"], "h": {"id": "C0029124", "name": "C0029124#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1424852", "name": "C1424852#ent", "pos": [20, 21]}}
{"token": ["To", "investigate", "the", "relation", "of", "C1415563#ent", "<e1>", "and", "DMB", "C0002085#ent", "<e2>", "to", "the", "development", "of", "rheumatoid", "arthritis", "RA", ")", "."], "h": {"id": "C1415563", "name": "C1415563#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [9, 10]}}
{"token": ["Moderate", "titers", "C1415900#ent", "<e1>", "were", "produced", "by", "cells", "contained", "in", "B", "cell", "fractions", "surface", "immunoglobulin-positive", "C1706319#ent", "<e2>", "+", ",", "and", "Leu-12", "+", ")", ",", "and", "cells", "contained", "in", "natural", "killer", "cell", "fractions", "Leu-11", "+", "and", "OKM1", "+", ")", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706319", "name": "C1706319#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "C1098658#ent", "<e1>", "is", "critical", "for", "repression", "by", "multiple", "nuclear", "receptors", "the", "C1366355#ent", "<e2>", "a", "unique", "and", "necessary", "role", "in", "TR-mediated", "gene", "repression", "human", "293T", "cells"], "h": {"id": "C1098658", "name": "C1098658#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366355", "name": "C1366355#ent", "pos": [13, 14]}}
{"token": ["Synergism", "between", "calcium", "and", "TPA", "was", "blocked", "by", "C0040979#ent", "<e1>", ",", "chlorpromazine", ",", "and", "C0078437#ent", "<e2>", "[", "N-(6-aminohexyl)5-chloro-1-napthalenesulfonamide", "]", "at", "concentrations", "that", "had", "no", "effect", "LH", "release", "mediated", "by", "TPA", "alone", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078437", "name": "C0078437#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "graft-versus-host", "disease", "survival", "(", "C2347435#ent", "<e1>", ")", "and", "the", "C2926735#ent", "<e2>", "of", "systemic", "immunosuppressive", "treatment", "(", "IST", ")", "in", "82", "patients", "who", "developed", "chronic", "GVHD", "allogeneic", "haematopoietic", "cell", "transplantation", "HCT", ")", "."], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [11, 12]}}
{"token": ["A", "C0041834#ent", "<e1>", "lasting", "pigmentation", "is", "attributed", "to", "C0771570#ent", "<e2>"], "h": {"id": "C0041834", "name": "C0041834#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0771570", "name": "C0771570#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "pharmacodynamic", "and/or", "pharmacokinetic", "effect", "AZA", "independent", "of", "its", "C0003286#ent", "<e1>", "contribute", "to", "the", "potentiation", "of", "the", "C1335208#ent", "<e2>", "action", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335208", "name": "C1335208#ent", "pos": [20, 21]}}
{"token": ["The", "aqueous", "phase", "polypeptides", "a", "high", "molecular", "mass", "polypeptide", "identified", "as", "a", "membrane", "dynein", ",", "detergent-soluble", "alpha", "and", "C3539817#ent", "<e1>", "and", "numerous", "C1305923#ent", "<e2>", "distinct", "from", "those", "found", "in", "axonemes", "."], "h": {"id": "C3539817", "name": "C3539817#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [22, 23]}}
{"token": ["The", "data", "support", "the", "concept", "that", "in", "UBSM", "C1367657#ent", "<e1>", "activates", "BK", "channels", "elevating", "C0001477#ent", "<e2>", "through", "VDCC", "and", "by", "increasing", "C0001477#ent", "<e2>", "sparks", ",", "but", "not", "through", "a", "Ca(2+)-independent", "mechanism", "."], "h": {"id": "C1367657", "name": "C1367657#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [14, 15]}}
{"token": ["Both", "types", "of", "C1705556#ent", "<e1>", "were", "hydrolysed", "by", "C0040900#ent", "<e2>"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040900", "name": "C0040900#ent", "pos": [8, 9]}}
{"token": ["The", "levels", "of", "these", "kinases", "are", "known", "to", "change", "in", "pathological", "situations", "as", "C0018802#ent", "<e1>", "hypertrophy", "and", "hypertension", ",", "and", "in", "animal", "models", "these", "C0012634#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["The", "modulation", "of", "GRK", "activity", "in", "animal", "models", "cardiac", "diseases", "be", "effective", "to", "restore", "cardiac", "function", "C0018802#ent", "<e1>", "opens", "a", "novel", "therapeutic", "strategy", "C0012634#ent", "<e2>", "with", "GPCR", "dysregulation", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [23, 24]}}
{"token": ["We", "also", "find", "that", "genes", "encoding", "C1137282#ent", "<e1>", "are", "induced", "by", "C0022471#ent", "<e2>", "by", "electroshock-induced", "convulsions", "."], "h": {"id": "C1137282", "name": "C1137282#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [11, 12]}}
{"token": ["Clinical", "safety", "efficacy", "studies", "necessary", "to", "determine", "if", "topical", "C0025872#ent", "<e1>", "will", "prove", "useful", "for", "the", "treatment", "of", "C0035854#ent", "<e2>"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0035854", "name": "C0035854#ent", "pos": [18, 19]}}
{"token": ["Using", "recombinant", "plasmids", "sequences", "of", "the", "HSV", "1", "VP5", ",", "p40", ",", "C0012892#ent", "<e1>", "major", "DNA", "binding", "protein", "and", "TK", "C1333402#ent", "<e2>", "homologous", "sequences", "detected", "in", "all", "four", "simian", "viruses"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [20, 21]}}
{"token": ["To", "evaluate", "the", "diagnostic", "value", "streptococcal", "serology", "adult", "early", "C0003864#ent", "<e1>", "patients", "in", "discriminating", "between", "post-streptococcal", "reactive", "arthritis", "C1290140#ent", "<e2>", ")", "and", "C0003864#ent", "<e1>", "with", "other", "causes", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C1290140", "name": "C1290140#ent", "pos": [18, 19]}}
{"token": ["Expressions", "of", "integrin", "alpha2", "alpha3", ",", "alpha5", ",", "and", "beta1", ",", "C1334901#ent", "<e1>", "NCAM", ")", ",", "and", "matrix", "metalloproteinases", "C3494976#ent", "<e2>", ")", "were", "examined", "by", "flow", "cytometry"], "h": {"id": "C1334901", "name": "C1334901#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [19, 20]}}
{"token": ["VL-irradiated", "CQ", ",", "BZ", ",", "BP", ",", "and", "9-F", "+", "/-DMT", "continued", "to", "generate", "significant", "amounts", "of", "C0812281#ent", "<e1>", "90", "min", "after", "C1424729#ent", "<e2>", "irradiation", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1424729", "name": "C1424729#ent", "pos": [22, 23]}}
{"token": ["Of", "various", "carbohydrates", "and", "amino", "acids", "tested", ",", "glucose", ",", "mannose", ",", "fructose", ",", "and", "C0017789#ent", "<e1>", "were", "the", "most", "efficient", "substrates", "C0025517#ent", "<e2>", "by", "the", "endospores", "and", "spherules", "of", "Coccidioides", "immitis"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [22, 23]}}
{"token": ["We", "studied", "the", "effects", "of", "epidermal", "growth", "factor", "EGF", ")", ",", "C1336679#ent", "<e1>", "TSH", ")", "and", "amiloride", "on", "cytoplasmic", "pH", "C1333690#ent", "<e2>", ")", "in", "cultured", "porcine", "thyroid", "cells"], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "both", "bopindolol", "and", "pindolol", "reduce", "C1415740#ent", "<e1>", "and", "heart", "rate", "pithed", "rats", "through", "some", "mechanism", "independent", "of", "C0001644#ent", "<e2>", "."], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [21, 22]}}
{"token": ["Focal", "adhesion", "kinase", "C1565427#ent", "<e1>", ")", "is", "a", "substrate", "of", "both", "caspase-3", "and", "C1705064#ent", "<e2>", ",", "and", "inactivation", "of", "C1565427#ent", "<e1>", "by", "these", "caspases", "promotes", "apoptosis", "."], "h": {"id": "C1705064", "name": "C1705064#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [3, 4]}}
{"token": ["WASP", "contains", "C3274827#ent", "<e1>", "interact", "with", "various", "signalling", "proteins", "including", "the", "guanine", "triphosphatase", "GTPase", ")", "C1705433#ent", "<e2>", "and", "SH3", "domain-containing", "proteins"], "h": {"id": "C3274827", "name": "C3274827#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705433", "name": "C1705433#ent", "pos": [15, 16]}}
{"token": ["Hypotension", "is", "the", "most", "frequent", "side", "effect", "C0116569#ent", "<e1>", ",", "while", "bradycardia", ",", "C0018802#ent", "<e2>", "hypotension", "and", "cardiogenic", "shock", "the", "most", "important", "contraindications", "for", "its", "use", "."], "h": {"id": "C0116569", "name": "C0116569#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["Several", "recent", "reports", "indicate", "that", "another", "class", "of", "C1528775#ent", "<e1>", "(", "G", ")", "protein", ",", "the", "C0752348#ent", "<e2>", "also", "participates", "in", "the", "regulation", "of", "vesicular", "traffic", "."], "h": {"id": "C1528775", "name": "C1528775#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [16, 17]}}
{"token": ["Significant", "clinical", "findings", "included", "the", "presence", "of", "abundant", "granulation", "tissue", "mastoids", "with", "good", "pneumatization", ",", "cervical", "lymphadenopathy", "profound", "hearing", "loss", "C0015469#ent", "<e1>", "and", "foci", "of", "C0041296#ent", "<e2>", "other", "sites", "."], "h": {"id": "C0015469", "name": "C0015469#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [25, 26]}}
{"token": ["The", "formation", "of", "C0010763#ent", "<e1>", "from", "the", "reaction", "of", "dimethylamine", "and", "nitrous", "acid", "C0008232#ent", "<e2>", "was", "effectively", "inhibited", "by", "methyl", "linoleate", "hydroperoxide"], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008232", "name": "C0008232#ent", "pos": [13, 14]}}
{"token": ["Immunoreactivity", "of", "both", "C9", "neoantigen", "and", "vitronectin", "was", "detected", "in", "the", "C1711257#ent", "<e1>", "in", "specimens", "of", "C0024138#ent", "<e2>", "in", "the", "tips", "of", "dermal", "papillae", "specimens", "of", "dermatitis", "herpetiformis"], "h": {"id": "C1711257", "name": "C1711257#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024138", "name": "C0024138#ent", "pos": [16, 17]}}
{"token": ["Lymphangiectasia", "of", "the", "small", "intestine", "demonstrated", "in", "9", "to", "18", "cases", "with", "C0302858#ent", "<e1>", "in", "10", "of", "26", "cases", "with", "C0004943#ent", "<e2>"], "h": {"id": "C0302858", "name": "C0302858#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [20, 21]}}
{"token": ["C0078847#ent", "<e1>", "significantly", "shortened", "the", "sleep", "latency", "following", "morning", ",", "whereas", "C0724725#ent", "<e2>", "did", "not", ",", "perhaps", "due", "to", "the", "difference", "in", "the", "elimination", "half-lives", "between", "the", "compounds", "."], "h": {"id": "C0078847", "name": "C0078847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0724725", "name": "C0724725#ent", "pos": [11, 12]}}
{"token": ["Several", "thiazolidinediones", "2", "C1709439#ent", "<e1>", "inhibitory", "activity", "in", "the", "low", "micromolar", "range", "with", "moderate", "selectivity", "for", "human", "C1709439#ent", "<e1>", "and", "IF1", "isoform", "of", "human", "C1412131#ent", "<e1>", "compared", "with", "other", "related", "PTPs", "."], "h": {"id": "C1709439", "name": "C1709439#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412131", "name": "C1412131#ent", "pos": [24, 25]}}
{"token": ["Autonomic", "measures", "skin", "conductance", "C3543842#ent", "<e1>", "skin", "conductance", "level", ",", "SCL", ",", "and", "phasic", "skin", "conductance", ",", "C0010278#ent", "<e2>", ")", "were", "acquired", "simultaneously", "with", "central", "EEG/ERP", "measures", "."], "h": {"id": "C3543842", "name": "C3543842#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [17, 18]}}
{"token": ["A", "single", "injection", "of", "estradiol", "valerate", "a", "form", "of", "C0029927#ent", "<e1>", "some", "aspects", "of", "the", "human", "C0032460#ent", "<e2>"], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [16, 17]}}
{"token": ["In", "one", ",", "who", "presented", "with", "hirsutism", ",", "oligomenorrhea", ",", "obesity", ",", "infertility", ",", "and", "enlarged", "C0029927#ent", "<e1>", "the", "initial", "diagnosis", "was", "C0032460#ent", "<e2>"], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [22, 23]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "C0029927#ent", "<e1>", "during", "GnRH-a/hMG", "treatment", "in", "patients", "with", "C0032460#ent", "<e2>", "PCOS", ")", "."], "h": {"id": "C0029927", "name": "C0029927#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [17, 18]}}
{"token": ["These", "C0812310#ent", "<e1>", "specific", "and", "could", "not", "be", "displaced", "by", "unlabeled", "C1366571#ent", "<e2>", "."], "h": {"id": "C0812310", "name": "C0812310#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [11, 12]}}
{"token": ["GRO", "alpha", "C0812310#ent", "<e1>", "and", "GRO", "gamma", "like", "C1366571#ent", "<e2>", ",", "induced", "chemotaxis", ",", "shape", "change", "a", "rise", "in", "intracellular", "free", "calcium", "levels", ",", "exocytosis", ",", "and", "the", "respiratory", "burst", "neutrophils", "."], "h": {"id": "C0812310", "name": "C0812310#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [8, 9]}}
{"token": ["Human", "GRO", "alpha", "C0812310#ent", "<e1>", "and", "GRO", "gamma", "neutrophil", "chemoattractants", "structurally", "related", "to", "C1366571#ent", "<e2>", "and", "compete", "with", "C1366571#ent", "<e2>", "for", "binding", "to", "IL-8", "receptors", "neutrophils", "."], "h": {"id": "C0812310", "name": "C0812310#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [13, 14]}}
{"token": ["Several", "case-control", "studies", "that", "elevated", "homocysteinemia", "(", "HC", ")", "is", "a", "risk", "factor", "C0007222#ent", "<e1>", "particularly", "for", "acute", "myocardial", "infarction", "C0155626#ent", "<e2>", ")", "."], "h": {"id": "C0007222", "name": "C0007222#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [20, 21]}}
{"token": ["Approximately", "three-quarters", "of", "C0007222#ent", "<e1>", "deaths", "in", "the", "world", "come", "from", "developing", "countries", "and", "acute", "myocardial", "infarction", "C0155626#ent", "<e2>", ")", "is", "an", "important", "cause", "of", "death", "."], "h": {"id": "C0007222", "name": "C0007222#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [17, 18]}}
{"token": ["N-terminal", "phosphorylated", "PSD-95", "is", "found", "in", "C1418591#ent", "<e1>", "fractions", "together", "with", "cdk5", "and", "its", "C1422492#ent", "<e2>", ",", "p35", ",", "suggesting", "a", "role", "for", "phosphorylated", "PSD-95", "at", "synapses", "."], "h": {"id": "C1418591", "name": "C1418591#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [14, 15]}}
{"token": ["All", "but", "1", "of", "our", "30", "cases", "expressed", "C1412409#ent", "<e1>", "and/or", "CD33", ";", "2", "expressed", "CD19", ";", "1", "expressed", "C0025250#ent", "<e2>", ";", "none", "expressed", "both", "C0025250#ent", "<e2>", "and", "CD19", "."], "h": {"id": "C1412409", "name": "C1412409#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [19, 20]}}
{"token": ["These", "results", "demonstrate", "that", "enkephalinase", "B", "the", "C1412409#ent", "<e1>", "but", "not", "the", "soluble", "aminopeptidase", "or", "C0025250#ent", "<e2>", "hydrolyse", "enkephalins", "in", "the", "isolated", "guinea-pig", "ileum"], "h": {"id": "C1412409", "name": "C1412409#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [15, 16]}}
{"token": ["The", "values", "of", "IC50", "were", "0.39", "microM", "for", "C1412409#ent", "<e1>", "\"", "enkephalin-aminopeptidase", "\"", ")", "and", "5.6", "microM", "C0025250#ent", "<e2>", "\"", "enkephalinase", "A", ")", "."], "h": {"id": "C1412409", "name": "C1412409#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [17, 18]}}
{"token": ["This", "study", "compared", "the", "efficacy", "and", "safety", "of", "pravastatin", "and", "C0017245#ent", "<e1>", "in", "the", "treatment", "of", "C0020443#ent", "<e2>"], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [16, 17]}}
{"token": ["Standard", "\"", "options", "with", "long-term", "results", "on", "outcome", "include", "orchiectomy", ",", "monotherapy", "with", "a", "luteinizing", "hormone-releasing", "hormone", "C1706334#ent", "<e1>", ")", "C0243192#ent", "<e2>", ",", "and", "combined", "androgen", "blockade", "an", "C1706334#ent", "<e1>", "C0243192#ent", "<e2>", "and", "antiandrogen", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1706334", "name": "C1706334#ent", "pos": [17, 18]}}
{"token": ["Should", "this", "fail", ",", "prior", "treatment", "with", "an", "C1706334#ent", "<e1>", "C0243192#ent", "<e2>", "and", "if", "not", "the", "pulsed", "administration", "of", "C1706334#ent", "<e1>", "in", "non-obese", "women", "can", "be", "suggested", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706334", "name": "C1706334#ent", "pos": [8, 9]}}
{"token": ["Previous", "studies", "have", "shown", "that", "the", "exposure", "of", "embryonic", "murine", "in", "vitro", "C0163054#ent", "<e1>", "(", "4-OOHCPA", ")", ",", "an", "activated", "analog", "of", "the", "C0282532#ent", "<e2>", "cyclophosphamide", ",", "induced", "limb", "malformations", "apoptosis", "."], "h": {"id": "C0163054", "name": "C0163054#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282532", "name": "C0282532#ent", "pos": [23, 24]}}
{"token": ["This", "study", "is", "to", "investigate", "the", "reactivity", "of", "norepinephrine", "and", "C0733398#ent", "<e1>", "on", "intracranial", "pressure", "ICP", ")", "in", "patients", "with", "severe", "C0151740#ent", "<e2>"], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [21, 22]}}
{"token": ["The", "study", "emphasizes", "the", "importance", "of", "making", "a", "distinction", "between", "simple", "C0848309#ent", "<e1>", "C0848309#ent", "<e1>", "associated", "with", "symptoms", "and", "C0029896#ent", "<e1>", "."], "h": {"id": "C0848309", "name": "C0848309#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "that", "C1419317#ent", "<e1>", "gene", "expression", "be", "modulated", "by", "both", "retinoic", "acid", "C0011777#ent", "<e2>", "in", "the", "vitamin", "A-sufficient", "animal", "."], "h": {"id": "C1419317", "name": "C1419317#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [13, 14]}}
{"token": ["Unlike", "C0010620#ent", "<e1>", ",", "MS", "is", "not", "active", "in", "the", "C0030038#ent", "<e2>"], "h": {"id": "C0010620", "name": "C0010620#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030038", "name": "C0030038#ent", "pos": [10, 11]}}
{"token": ["Overdosage", "with", "the", "C0026457#ent", "<e1>", ",", "lithium", "and", "C0006949#ent", "<e2>", "is", "dangerous", "but", "not", "common", ";", "overdose", "with", "a", "TCA", "is", "a", "major", "source", "of", "morbidity", "and", "mortality", "."], "h": {"id": "C0026457", "name": "C0026457#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006949", "name": "C0006949#ent", "pos": [8, 9]}}
{"token": ["Sequencing", "of", "the", "amplified", "C1852404#ent", "<e1>", "fragments", "showed", "in", "5", "patients", "that", "C1412615#ent", "<e2>", "exon", "3", "fused", "with", "EWS", "exon", "10", "resulting", "in", "an", "out-of-frame", "chimeric", "transcript", "."], "h": {"id": "C1852404", "name": "C1852404#ent", "pos": [4, 5]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1412615", "name": "C1412615#ent", "pos": [12, 13]}}
{"token": ["C1433276#ent", "<e1>", "were", "increased", "by", "pilocarpine", ",", "scopolamine", ",", "mecamylamine", "and", "C0009014#ent", "<e2>", ",", "but", "not", "by", "nicotine", "or", "idazoxan", "."], "h": {"id": "C1433276", "name": "C1433276#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "C2348308#ent", "<e1>", "as", "well", "as", "8-Br-cADPR", "abrogated", "C0051844#ent", "<e2>", "II-mediated", "Akt", "phosphorylation", ",", "nuclear", "translocation", "nuclear", "factor", "activated", "T", "cell", "and", "uptake", "of", "[(3)H]thymidine", "and", "[(3)H]leucine", "in", "MMCs", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [9, 10]}}
{"token": ["The", "yawning", "induced", "by", "physostigmine", ",", "an", "C0008425#ent", "<e1>", "and", "pilocarpine", ",", "a", "direct", "muscarinic", "receptor", "agonist", "was", "increased", "by", "C0031937#ent", "<e2>", ",", "but", "was", "unaffected", "by", "prazosin", "and", "bunazosin", "."], "h": {"id": "C0008425", "name": "C0008425#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031937", "name": "C0031937#ent", "pos": [20, 21]}}
{"token": ["The", "enzyme", "displays", "40", "-", "45", "%", "identity", "to", "other", "members", "of", "the", "human", "C1313497#ent", "<e1>", "and", "its", "closest", "C1334043#ent", "<e2>", "(", "75", "%", "identity", ")", "is", "the", "rat", "tryptase", "RNK-tryp2", "."], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [19, 20]}}
{"token": ["Yeast", "two-hybrid", "of", "a", "bovine", "retinal", "cDNA", "library", "the", "cytoplasmic", "domain", "C1334133#ent", "<e1>", "a", "novel", "member", "of", "the", "Grb7", "C1517488#ent", "<e2>", "Grb14", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [19, 20]}}
{"token": ["This", "study", "investigated", "both", "variables", "as", "a", "marker", "for", "C0156149#ent", "<e1>", "patients", "with", "a", "ruptured", "C0162871#ent", "<e2>", "."], "h": {"id": "C0156149", "name": "C0156149#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162871", "name": "C0162871#ent", "pos": [15, 16]}}
{"token": ["C1332737#ent", "<e1>", "(", "p27", ")", "is", "a", "C0536221#ent", "<e2>", "in", "regulation", "of", "cell", "cycling", "signal", "transduction", "and", "adhesion", "."], "h": {"id": "C1332737", "name": "C1332737#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [7, 8]}}
{"token": ["Werner", "syndrome", "C0175702#ent", "<e1>", ")", "is", "a", "human", "C0406586#ent", "<e2>", "characterized", "by", "the", "early", "onset", "a", "large", "number", "of", "clinical", "features", "associated", "with", "normal", "aging", "process", "."], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0406586", "name": "C0406586#ent", "pos": [8, 9]}}
{"token": ["Permanently", "transfected", "cell", "lines", "overexpress", "wild", "type", "C1366449#ent", "<e1>", "demonstrated", "constitutive", "increases", "in", "AP-1", "C0812382#ent", "<e2>", "well", "as", "AP-1-dependent", "reporter", "gene", ",", "relative", "to", "vector", "control", "cells"], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "the", "transcriptional", "properties", "of", "C1366449#ent", "<e1>", "depend", "on", "the", "type", "of", "the", "C1366449#ent", "<e1>", "C0812382#ent", "<e1>"], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [16, 17]}}
{"token": ["The", "possible", "correlation", "between", "the", "induced", "proteins", "described", "here", "and", "the", "elevated", "levels", "of", "certain", "C3541394#ent", "<e1>", "in", "interferon-treated", "cells", "(", "a", "protein", "kinase", "C1417913#ent", "<e2>", "is", "at", "present", "unclear", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1417913", "name": "C1417913#ent", "pos": [24, 25]}}
{"token": ["Retinitis", "reminiscent", "of", "the", "C0035319#ent", "<e1>", "recognized", "in", "a", "patient", "with", "C0001849#ent", "<e2>", "he", "had", "experienced", "several", "episodes", "of", "a", "sacral", ",", "dermatomic", "zosteriform", "eruption", "."], "h": {"id": "C0035319", "name": "C0035319#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001849", "name": "C0001849#ent", "pos": [11, 12]}}
{"token": ["Since", "CYP3A2", "is", "absent", "or", "very", "low", "in", "hepatic", "microsomes", "from", "DEX-treated", "adult", "female", "rats", ",", "this", "identifies", "C1176140#ent", "<e1>", "as", "an", "isoform", "capable", "of", "biotransforming", "C0731141#ent", "<e2>", "to", "an", "activator", "of", "guanylyl", "cyclase"], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0731141", "name": "C0731141#ent", "pos": [26, 27]}}
{"token": ["In", "conclusion", ",", "our", "results", "demonstrate", "that", "C1176140#ent", "<e1>", "aorta", "is", "correlated", "with", "C0731141#ent", "<e2>", "bioactivation", "in", "vivo", "but", "the", "contribution", "of", "this", "enzyme", "to", "overall", "C0731141#ent", "<e2>", "bioactivation", "is", "limited", "."], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0731141", "name": "C0731141#ent", "pos": [13, 14]}}
{"token": ["The", "Case", "1", "the", "gastrointestinal", "symptoms", "as", "epigastric", "pain", "indigestion", ",", "and", "the", "Case", "2", "heart", "problems", "as", "arrhythmia", "and", "ventricular", "premature", "beat", "EKG", "and", "C0037089#ent", "<e1>", "as", "diarrhea", "and", "C0000737#ent", "<e2>"], "h": {"id": "C0037089", "name": "C0037089#ent", "pos": [25, 26]}, "relation": "nichd_parent_of", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [30, 31]}}
{"token": ["Passive", "Heymann", "nephritis", "PHN", ")", ",", "a", "model", "of", "human", "C0017665#ent", "<e1>", "is", "an", "C0744421#ent", "<e2>", "by", "the", "presence", "of", "complement-dependent", "tissue", "injury", "."], "h": {"id": "C0017665", "name": "C0017665#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0744421", "name": "C0744421#ent", "pos": [14, 15]}}
{"token": ["The", "C0268412#ent", "<e1>", "complex", ",", "in", "addition", ",", "contains", "Vps41/Vam2", "and", "C1427020#ent", "<e2>", ",", "whereas", "the", "CORVET", "complex", "has", "the", "Vps41", "homolog", "Vps8", "and", "the", "(h)Vam6", "homolog", "Vps3", "."], "h": {"id": "C0268412", "name": "C0268412#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1427020", "name": "C1427020#ent", "pos": [11, 12]}}
{"token": ["The", "rps3-rpl16-rpl5-rps14", "region", "of", "B.", "napus", "mtDNA", "may", "function", "as", "a", "ribosomal", "operon", "similar", "to", "the", "S10", "and", "C1442758#ent", "<e1>", "operons", "of", "Escherichia", "coli", "to", "the", "ribosomal", "protein", "operon", "the", "C1955992#ent", "<e2>", "Euglena", "gracilis"], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1955992", "name": "C1955992#ent", "pos": [30, 31]}}
{"token": ["C3274910#ent", "<e1>", "dissolved", "in", "C0074722#ent", "<e2>", "was", "intravesically", "instilled", "for", "60", "min", "in", "tumour-bearing", "and", "normal", "bladders", "of", "Wistar", "rats"], "h": {"id": "C3274910", "name": "C3274910#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0074722", "name": "C0074722#ent", "pos": [4, 5]}}
{"token": ["Identification", "of", "a", "gene", "involved", "in", "checkpoint", "control", "a", "rescue", "of", "a", "C3811768#ent", "<e1>", "mutant", "links", "the", "rad1-dependent", "DNA-damage-sensing", "pathway", "and", "C1707108#ent", "<e2>"], "h": {"id": "C3811768", "name": "C3811768#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1707108", "name": "C1707108#ent", "pos": [21, 22]}}
{"token": ["Mammalian", "enamel", "forms", "enamel-specific", "proteins", "such", "as", "amelogenin", ",", "whereas", "dentin", "and", "bone", "form", "on", "C0009325#ent", "<e1>", "and", "many", "acidic", "proteins", "such", "as", "C1425046#ent", "<e2>", ",", "coordinately", "regulate", "their", "mineralization", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1425046", "name": "C1425046#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "C0085170#ent", "<e1>", "is", "effective", "in", "the", "treatment", "of", "patients", "with", "C0035457#ent", "<e2>", "seasonal", "enhancement", "symptoms", "."], "h": {"id": "C0085170", "name": "C0085170#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [13, 14]}}
{"token": ["No", "significant", "was", "found", "between", "the", "IgA", ",", "IgG", "and", "C1706005#ent", "<e1>", "levels", "of", "pulpal", "and", "peripheral", "blood", "C0020488#ent", "<e2>", "and", "acute", "serous", "pulpitis", "cases", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020488", "name": "C0020488#ent", "pos": [18, 19]}}
{"token": ["In", "2", "patients", "an", "isolated", "C1856716#ent", "<e1>", "suspected", "on", "the", "basis", "of", "undetectable", "C0016424#ent", "<e2>", "levels", "unresponsive", "to", "the", "infusion", "of", "GnRH", "."], "h": {"id": "C1856716", "name": "C1856716#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016424", "name": "C0016424#ent", "pos": [13, 14]}}
{"token": ["In", "all", "tissues", "examined", ",", "the", "activity", "of", "C0031727#ent", "<e1>", "4.6", "to", "18", "%", "of", "that", "of", "C0089793#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [17, 18]}}
{"token": ["The", "C0031727#ent", "<e1>", "conditions", "are", "similar", "to", "those", "used", "for", "C0089793#ent", "<e2>", "except", "that", "ATP", "and", "Mg2", "+", "are", "omitted", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [10, 11]}}
{"token": ["In", "this", "paper", "we", "demonstrate", "that", "cytoskeletons", "isolated", "from", "A431", "cells", "have", "associated", "with", "high", "activities", "of", "several", "C0031727#ent", "<e1>", "involved", "in", "inositol", "lipid", "metabolism", "such", "as", "C0089793#ent", "<e2>", "phosphatidylinositol", "phosphate", "kinase", "and", "diacylglycerol", "kinase"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [27, 28]}}
{"token": ["In", "both", "C3889249#ent", "<e1>", "and", "MCF", ",", "C1335837#ent", "<e2>", "2", "was", "generally", "decreased", "or", "partially", "absent", "at", "all", "time", "points"], "h": {"id": "C3889249", "name": "C3889249#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335837", "name": "C1335837#ent", "pos": [7, 8]}}
{"token": ["Also", "deaths", "from", "worsening", "C0018801#ent", "<e1>", "fewer", "in", "the", "C0025859#ent", "<e2>", "group", "(", "30", "versus", "58", "deaths", ")", ",", "RR", "0.51", "(", "p", "=", "0.0023", ")", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [9, 10]}}
{"token": ["In", "the", "present", "comparative", "study", "applied", "the", "nerve", "excitability", "test", "(", "C1705456#ent", "<e1>", ")", "and", "the", "maximum", "stimulation", "test", "C1417246#ent", "<e2>", ")", "to", "131", "patients", "with", "idiopathic", "facial", "nerve", "palsy"], "h": {"id": "C1705456", "name": "C1705456#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417246", "name": "C1417246#ent", "pos": [19, 20]}}
{"token": ["We", "isolated", "C1421971#ent", "<e1>", "cDNA", "from", "C4049865#ent", "<e2>", "library", "by", "a", "yeast", "two-hybrid", "screening", "using", "Trip15/CSN2", "as", "a", "bait", "."], "h": {"id": "C1421971", "name": "C1421971#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4049865", "name": "C4049865#ent", "pos": [6, 7]}}
{"token": ["Because", "C0039286#ent", "<e1>", "(", "TAM", ")", "is", "known", "to", "be", "metabolized", "by", "C1142644#ent", "<e2>", "and", "P-glycoprotein", ",", "we", "investigated", "the", "effect", "of", "TAM", "on", "these", "SXR-targeted", "genes", "in", "breast", "cancer", "cells"], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [1, 2]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}}
{"token": ["Similar", "inhibition", "and", "correlation", "experiments", "that", "C0039286#ent", "<e1>", "N-demethylation", "is", "catalysed", "predominantly", "by", "C1142644#ent", "<e2>", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [6, 7]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [13, 14]}}
{"token": ["Protease", "nexin-1", "PN-1", ")", "is", "a", "serine", "protease", "inhibitor", "C0035179#ent", "<e1>", ")", "that", "inactivates", "several", "proteases", ",", "including", "thrombin", ",", "C1522670#ent", "<e2>", ",", "plasminogen", "activators", "PA", ")", ",", "and", "plasmin", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1522670", "name": "C1522670#ent", "pos": [20, 21]}}
{"token": ["The", "diseases", "were", "Tay-Sachs", "disease", "C0027877#ent", "<e1>", "(", "Jansky-Bielschowsky", "type", ",", "Niemann-Pick", "disease", "type", "B", ",", "highly", "suspected", "C1412084#ent", "<e2>", ",", "I-cell", "disease", "mucolipidosis", "of", "the", "beta-galactosidase", "deficient", "type", "Hurler", "disease", "Hunter", "disease", "Morquio", "disease"], "h": {"id": "C0027877", "name": "C0027877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412084", "name": "C1412084#ent", "pos": [18, 19]}}
{"token": ["Pathognomonic", "inclusions", "of", "specific", "shape", "allow", "accurate", "diagnosis", "in", "ceroid", "C0027877#ent", "<e1>", "generalized", "glycogenosis", "Tangier", "disease", "metachromatic", "and", "globoid", "leukodystrophy", "and", "sometimes", "in", "C1412084#ent", "<e2>", "."], "h": {"id": "C0027877", "name": "C0027877#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412084", "name": "C1412084#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "cotreatment", "of", "1", "microM", "arsenic", "trioxide", "As2O3", ")", "with", "various", "concentrations", "of", "C1708276#ent", "<e1>", "enhanced", "an", "LAA-induced", "repression", "of", "NF-kappaB", "activity", "C1565860#ent", "<e2>", "expression", "."], "h": {"id": "C1708276", "name": "C1708276#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [23, 24]}}
{"token": ["C1414571#ent", "<e1>", "stimulated", "the", "oxidation", "of", "NADPH", "by", "C1096793#ent", "<e2>", ",", "catalyzed", "by", "NADPH", ":", "adrenodoxin", "reductase"], "h": {"id": "C1414571", "name": "C1414571#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1096793", "name": "C1096793#ent", "pos": [8, 9]}}
{"token": ["A", "potential", "candidate", "C0017337#ent", "<e1>", "for", "bone", "formation", "the", "linked", "region", "on", "chromosome", "20", "C1333666#ent", "<e2>", ",", "which", "encodes", "cartilage-derived", "morphogenetic", "protein", "1"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333666", "name": "C1333666#ent", "pos": [14, 15]}}
{"token": ["In", "addition", "to", "C0017337#ent", "<e1>", "encoding", "subunits", "of", "the", "20S", "proteasome", "C0017337#ent", "<e1>", "related", "to", "vacuolar", "proteolysis", "PEP4", "and", "C1333666#ent", "<e1>", ")", ",", "protein", "sorting", "the", "vacuole", ",", "and", "vacuolar", "fusion", "found", "to", "be", "induced", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333666", "name": "C1333666#ent", "pos": [19, 20]}}
{"token": ["In", "a", "shock-escape", "T-maze", "task", ",", "rats", "rapidly", "discriminated", "diazepam", ",", "C0242293#ent", "<e1>", "and", "chloridazepoxide", "from", "C0013227#ent", "<e2>"], "h": {"id": "C0242293", "name": "C0242293#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [16, 17]}}
{"token": ["The", "addition", "of", "C2347126#ent", "<e1>", "significantly", "reduced", "the", "PBMC", "proliferative", "response", "to", "C0030779#ent", "<e2>", "and", "anti-CD3", "MAb", "not", "to", "rIL-2", "."], "h": {"id": "C2347126", "name": "C2347126#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [12, 13]}}
{"token": ["Adenocarcinoma", "showed", "the", "highest", "density", "of", "reacting", "sites", "for", "BPA", "and", "C2347126#ent", "<e1>", ",", "and", "squamous", "cell", "carcinoma", "the", "highest", "binding", "sites", "C0030779#ent", "<e2>", ",", "while", "small-cell", "carcinoma", "the", "lowest", "reacting", "variant", "for", "all", "lectins", "."], "h": {"id": "C2347126", "name": "C2347126#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [22, 23]}}
{"token": ["Endopeptidase-24.18", "(", "EC", "3.4.24.18", ";", "C0733413#ent", "<e1>", ")", "is", "a", "C0025543#ent", "<e2>", "the", "astacin", "family"], "h": {"id": "C0733413", "name": "C0733413#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [10, 11]}}
{"token": ["C0167117#ent", "<e1>", "mRNA", "transcripts", "were", "expressed", "in", "the", "salivary", "gland", "but", "not", "C0771711#ent", "<e2>", "or", "intestine", "."], "h": {"id": "C0167117", "name": "C0167117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [12, 13]}}
{"token": ["The", "overexpression", "of", "C0919458#ent", "<e1>", "mrp", ")", "and", "anionic", "glutathione", "S-transferase", "C0796516#ent", "<e2>", "pi", ")", "was", "also", "investigated", "in", "38", "and", "61", "AML", "patients", "respectively", "."], "h": {"id": "C0919458", "name": "C0919458#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0796516", "name": "C0796516#ent", "pos": [11, 12]}}
{"token": ["In", "summary", ",", "we", "were", "able", "to", "demonstrate", "reduced", "expression", "levels", "of", "the", "cell-cycle", "inhibitor", "C1419040#ent", "<e1>", "in", "tumors", "derived", "from", "all", "C0032002#ent", "<e2>"], "h": {"id": "C1419040", "name": "C1419040#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [22, 23]}}
{"token": ["It", "might", "represent", "a", "possible", "way", "of", "action", "of", "the", "C1254351#ent", "<e1>", "in", "some", "neonatal", "disorders", "hyperbilirubinaemia", "and", "C0035344#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035344", "name": "C0035344#ent", "pos": [18, 19]}}
{"token": ["In", "the", "present", "study", ",", "we", "identified", "a", "novel", "C1419278#ent", "<e1>", "Ras-GAP", ")", "as", "an", "C1424881#ent", "<e2>", "AIP1", ")", "."], "h": {"id": "C1419278", "name": "C1419278#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1424881", "name": "C1424881#ent", "pos": [15, 16]}}
{"token": ["C0059438#ent", "<e1>", "inhibited", "cell", "proliferation", "induced", "by", "oncogenic", "C0034678#ent", "<e2>", "and", "blocked", "cell", "cycle", "transition", "G1", "phase", "inhibition", "of", "cyclin", "D1", "expression", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [8, 9]}}
{"token": ["The", "second", "serine", ",", "which", "augmented", "the", "inhibition", ",", "was", "at", "amino", "acid", "within", "the", "C2698408#ent", "<e1>", "(", "NEMO/IKKgamma", ")", "interaction", "site", "with", "C1442489#ent", "<e2>", "."], "h": {"id": "C2698408", "name": "C2698408#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1442489", "name": "C1442489#ent", "pos": [23, 24]}}
{"token": ["B", "lineage-specific", "disruption", "of", "either", "IKK", "signaling", "by", "deletion", "of", "C2698408#ent", "<e1>", ",", "or", "of", "IKK2-specific", "signals", "by", "ablation", "of", "C1442489#ent", "<e2>", "activity", "leads", "to", "the", "disappearance", "of", "mature", "B", "lymphocytes"], "h": {"id": "C2698408", "name": "C2698408#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1442489", "name": "C1442489#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "optimized", "inhibitor", "levels", "for", "modulating", "C4283740#ent", "<e1>", "prevent", "apoptosis", "induced", "by", "oxidative", "stress", "associated", "with", "C0751870#ent", "<e2>"], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [19, 20]}}
{"token": ["Levodopa", "with", "or", "without", "C1413943#ent", "<e1>", "not", "a", "cure", "for", "C0242422#ent", "<e2>", "."], "h": {"id": "C1413943", "name": "C1413943#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [10, 11]}}
{"token": ["Ondansetron", "(", "C0206046#ent", "<e1>", ",", "Glaxo", "Wellcome", ")", ",", "C0061863#ent", "<e2>", "(", "Kytril", ",", "SmithKline", "Beecham", "and", "dolasetron", "(", "Anzemet", ",", "Hoechst", "Marion", "Roussel", ")", "are", "commercially", "available", "in", "the", "US", "."], "h": {"id": "C0206046", "name": "C0206046#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0061863", "name": "C0061863#ent", "pos": [9, 10]}}
{"token": ["Early", "reports", "acquired", "disease", "frequent", "dermatologic", "manifestations", "whereas", "recent", "reviews", "of", "C0085315#ent", "<e1>", "stress", "the", "C0497156#ent", "<e2>", "presentation", "of", "the", "disease", "."], "h": {"id": "C0085315", "name": "C0085315#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0497156", "name": "C0497156#ent", "pos": [15, 16]}}
{"token": ["Prospective", "measurements", "cerebral", "blood", "flow", "C1428360#ent", "<e1>", ")", "and", "Cognitive", "Capacity", "Screening", "Examination", "(", "C2829370#ent", "<e2>", ")", "were", "obtained", "following", "head", "injury", "42", "patients", "for", "a", "mean", "total", "follow-up", "interval", "of", "10", "years", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2829370", "name": "C2829370#ent", "pos": [14, 15]}}
{"token": ["Amebiasis", "caused", "by", "C0002438#ent", "<e1>", "been", "a", "prevalent", "C0033740#ent", "<e2>", "Korea", "since", "old", "times", "."], "h": {"id": "C0002438", "name": "C0002438#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0033740", "name": "C0033740#ent", "pos": [8, 9]}}
{"token": ["In", "this", "study", ",", "we", "aimed", "to", "investigate", "the", "role", "of", "C1424666#ent", "<e1>", "CDKi", "in", "C0008373#ent", "<e2>", ",", "a", "disease", "characterized", "by", "the", "presence", "of", "hyperproliferative", "squamous", "epithelium"], "h": {"id": "C1424666", "name": "C1424666#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008373", "name": "C0008373#ent", "pos": [15, 16]}}
{"token": ["These", "apparently", "contradictory", "findings", "led", "us", "to", "hypothesize", "that", "the", "inhibitor", "may", "have", "a", "direct", "effect", "on", "the", "transport", "catalytic", "activity", "C2982484#ent", "<e1>", "that", "was", "independent", "of", "inhibition", "of", "the", "C0031727#ent", "<e2>", "."], "h": {"id": "C2982484", "name": "C2982484#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [30, 31]}}
{"token": ["Many", "receptors", "of", "this", "type", "are", "coupled", "to", "C0380091#ent", "<e1>", ",", "in", "some", "cases", ",", "other", "C0031672#ent", "<e2>", "."], "h": {"id": "C0380091", "name": "C0380091#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031672", "name": "C0031672#ent", "pos": [16, 17]}}
{"token": ["The", "expression", "of", "Gclc", ",", "the", "catalytic", "subunit", "C1825379#ent", "<e1>", ",", "was", "upregulated", "by", "Cu", "deficiency", "C1522380#ent", "<e2>", ",", "the", "modifier", "subunit", "was", "not", "affected", "."], "h": {"id": "C1825379", "name": "C1825379#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1522380", "name": "C1522380#ent", "pos": [16, 17]}}
{"token": ["High", "values", "of", "serum", "C1332656#ent", "<e1>", "were", "found", "in", "all", "cases", "of", "C0866112#ent", "<e2>"], "h": {"id": "C1332656", "name": "C1332656#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0866112", "name": "C0866112#ent", "pos": [12, 13]}}
{"token": ["Our", "objectives", "were", "to", "predict", "the", "long-term", "cost", "and", "efficacy", "of", "the", "angiotensin-converting", "enzyme", "C0072973#ent", "<e1>", ",", "in", "patients", "with", "C0011881#ent", "<e2>"], "h": {"id": "C0072973", "name": "C0072973#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [20, 21]}}
{"token": ["Lafora's", "disease", "an", "autosomal", "recessive", "progressive", "myoclonus", "epilepsy", "is", "caused", "by", "mutations", "in", "the", "EPM2A", "gene", "encoding", "a", "C1956000#ent", "<e1>", "DSP", ")", "named", "C1414435#ent", "<e2>", "."], "h": {"id": "C1956000", "name": "C1956000#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414435", "name": "C1414435#ent", "pos": [23, 24]}}
{"token": ["The", "ESR", "spectra", "the", "spin", "labeled", "C0038317#ent", "<e1>", "in", "the", "presence", "of", "C2986643#ent", "<e2>", "could", "be", "used", "to", "characterize", "the", "ligand-protein", "interaction", "at", "equilibrium", "without", "the", "need", "of", "a", "separation", "between", "bound", "and", "free", "species"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2986643", "name": "C2986643#ent", "pos": [12, 13]}}
{"token": ["Differential", "diagnoses", "light", "microscopy", "diabetic", "glomerulosclerosis", "C0017667#ent", "<e1>", ",", "amyloidosis", "and", "C0268743#ent", "<e2>"], "h": {"id": "C0017667", "name": "C0017667#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268743", "name": "C0268743#ent", "pos": [11, 12]}}
{"token": ["Validation", "of", "the", "bioanalytical", "method", "determination", "of", "C0908935#ent", "<e1>", "and", "3-hydroxydesloratadine", "was", "conducted", "using", "ultra", "high", "pressure", "liquid", "chromatography", "C2987155#ent", "<e2>", ")", "in", "conjunction", "with", "mix", "mode", "solid", "phase", "extraction"], "h": {"id": "C0908935", "name": "C0908935#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [19, 20]}}
{"token": ["Although", "structural", "abnormalities", "C0235946#ent", "<e1>", "white", "matter", "lesions", "are", "similar", "in", "DM2", "and", "C3250443#ent", "<e2>", ",", "changes", "in", "cerebral", "metabolites", "differentiate", "these", "disease", "groups", ",", "suggesting", "that", "the", "diseases", "differ", "in", "their", "neurocellular", "pathology"], "h": {"id": "C0235946", "name": "C0235946#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C3250443", "name": "C3250443#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "the", "extent", "of", "C0235946#ent", "<e1>", "investigated", "in", "vivo", "ten", "C3250443#ent", "<e2>", "and", "nine", "PROMM", "patients", "in", "comparison", "to", "age-matched", "healthy", "controls", "each", "group", "."], "h": {"id": "C0235946", "name": "C0235946#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C3250443", "name": "C3250443#ent", "pos": [13, 14]}}
{"token": ["There", "was", "a", "covariation", "between", "the", "three", "ranges", "of", "motion", ",", "suggesting", "that", "C0427008#ent", "<e1>", "in", "the", "C1335638#ent", "<e2>", "was", "a", "general", "condition", "all", "directions", "of", "movements", "."], "h": {"id": "C0427008", "name": "C0427008#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335638", "name": "C1335638#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "examined", "the", "neural", "and", "cognitive", "bases", "sex", "differences", "verbal", "memory", "57", "patients", "who", "underwent", "left", "anterior", "temporal", "lobectomy", "C2986600#ent", "<e1>", ")", "for", "the", "treatment", "of", "intractable", "C0751495#ent", "<e2>", "."], "h": {"id": "C2986600", "name": "C2986600#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [28, 29]}}
{"token": ["Finally", ",", "c-Fos", "expression", "in", "dorsal", "spinal", "cord", "noxious", "stimulation", "is", "significantly", "lower", "in", "C1394891#ent", "<e1>", "than", "in", "AL", "animals", ",", "indicating", "that", "C1418447#ent", "<e2>", "could", "block", "nociceptive", "information", "the", "spinal", "cord"], "h": {"id": "C1394891", "name": "C1394891#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418447", "name": "C1418447#ent", "pos": [23, 24]}}
{"token": ["Patients", "with", "bipolar", "disorder", "expressed", "significantly", "lower", "C1310550#ent", "<e1>", "levels", "in", "C1418482#ent", "<e2>", "than", "controls", "."], "h": {"id": "C1310550", "name": "C1310550#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [11, 12]}}
{"token": ["The", "important", "role", "of", "angiogenesis", ",", "and", "especially", "C1522575#ent", "<e1>", ",", "in", "the", "pathogenesis", "of", "C0263661#ent", "<e2>", "as", "RA", "suggests", "that", "antiangiogenic", "therapy", "be", "a", "useful", "adjunct", "to", "existing", "approaches", "in", "RA", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0263661", "name": "C0263661#ent", "pos": [15, 16]}}
{"token": ["Enhanced", "adrenergic", "stimulation", "and", "C3536742#ent", "<e1>", "release", "are", "important", "components", "of", "the", "pathophysiology", "of", "C0036690#ent", "<e2>", "."], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [14, 15]}}
{"token": ["We", "report", "the", "cloning", ",", "sequence", "analysis", "tissue", "distribution", "genomic", "organization", "and", "functional", "analysis", "a", "new", "member", "of", "the", "C1420196#ent", "<e1>", "NBC", ")", "family", ",", "C2983393#ent", "<e2>", ",", "from", "human", "skeletal", "muscle"], "h": {"id": "C1420196", "name": "C1420196#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2983393", "name": "C2983393#ent", "pos": [25, 26]}}
{"token": ["C3536880#ent", "<e1>", "particularly", "useful", "for", "decreasing", "triglyceride", "levels", "(", "as", "are", "C1449704#ent", "<e2>", ")", "and", "raising", "HDL-cholesterol", "levels", "."], "h": {"id": "C3536880", "name": "C3536880#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1449704", "name": "C1449704#ent", "pos": [11, 12]}}
{"token": ["We", "have", "cloned", "and", "sequenced", "a", "C1825546#ent", "<e1>", "a", "highly", "immunogenic", "rat", "histiocytoma", "C1337052#ent", "<e2>", "."], "h": {"id": "C1825546", "name": "C1825546#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1337052", "name": "C1337052#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "C1417563#ent", "<e1>", "expression", "in", "skeletal", "muscle", "fibres", "regulated", "by", "both", "C1417575#ent", "<e2>", "and", "neurogenic", "mechanisms", "."], "h": {"id": "C1417563", "name": "C1417563#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417575", "name": "C1417575#ent", "pos": [12, 13]}}
{"token": ["The", "occurrence", "of", "abdominal", "pain", "patients", "with", "polychondritis", "may", "result", "from", "several", "disorders", ",", "such", "as", "iatrogenic", "complications", ",", "digestive", "tract", "vasculitis", "C0009324#ent", "<e1>", "but", "also", "associated", "C0030326#ent", "<e2>"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0030326", "name": "C0030326#ent", "pos": [27, 28]}}
{"token": ["Amprolium", "and", "C0069341#ent", "<e1>", "showed", "very", "weak", "mutagenicities", "only", "for", "TA100", "with", "C1419029#ent", "<e2>", "for", "WP2", "hcr", "with", "and", "without", "C1419029#ent", "<e2>", "resp", "."], "h": {"id": "C0069341", "name": "C0069341#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419029", "name": "C1419029#ent", "pos": [12, 13]}}
{"token": ["We", "demonstrate", "here", "that", "C1422384#ent", "<e1>", "associates", "with", "a", "second", "C1565427#ent", "<e2>", "family", "member", ",", "PYK2", "."], "h": {"id": "C1422384", "name": "C1422384#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [10, 11]}}
{"token": ["In", "a", "prospective", "open", "study", "seven", "patients", "with", "persistent", "C0030246#ent", "<e1>", "plantaris", "were", "treated", "with", "oral", "Cyclosporin", "A", "(", "C0520680#ent", "<e2>", ")", "."], "h": {"id": "C0030246", "name": "C0030246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0520680", "name": "C0520680#ent", "pos": [19, 20]}}
{"token": ["Identical", "C0808901#ent", "<e1>", "nucleotide", "sequences", "in", "the", "majority", "of", "EWS-FLI1", "and", "C1851465#ent", "<e2>", "chimeric", "transcripts", "are", "fused", "to", "a", "portion", "of", "ETV1", "encoding", "an", "ETS", "domain", "sequence", "specific", "DNA-binding", "activity"], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [1, 2]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1851465", "name": "C1851465#ent", "pos": [11, 12]}}
{"token": ["POU-domain-containing", "cDNA", "have", "been", "isolated", "from", "the", "A2058", "human", "melanoma", "cell", "line", "are", "C1512488#ent", "<e1>", "to", "the", "brn-2", "gene", "encodes", "C1418762#ent", "<e2>", "and", "N-Oct-5", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418762", "name": "C1418762#ent", "pos": [20, 21]}}
{"token": ["In", "this", "study", "we", "show", "that", "C1705357#ent", "<e1>", "rapid", "phosphorylation", "of", "the", "adaptor", "protein", "C1336692#ent", "<e2>", "and", "intracellular", "kinases", "Syk", "and", "phospholipase", "C-gamma1"], "h": {"id": "C1705357", "name": "C1705357#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336692", "name": "C1336692#ent", "pos": [14, 15]}}
{"token": ["C0004364#ent", "<e1>", "such", "as", "bullous", "pemphigoid", "pemphigus", "vulgaris", "occasionally", "develop", "in", "C3890176#ent", "<e2>", "patients", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890176", "name": "C3890176#ent", "pos": [11, 12]}}
{"token": ["NAD(P)H", ":", "C0027280#ent", "<e1>", "NQO1", ")", "catalyses", "the", "two-electron", "reduction", "of", "C0003174#ent", "<e2>"], "h": {"id": "C0027280", "name": "C0027280#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003174", "name": "C0003174#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "show", "that", "endogenous", "C2348048#ent", "<e1>", "associates", "primarily", "with", "C1122259#ent", "<e2>", "as", "well", "as", ",", "to", "a", "lesser", "extent", ",", "with", "H3-K4", "enzymatic", "activity", "."], "h": {"id": "C2348048", "name": "C2348048#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1122259", "name": "C1122259#ent", "pos": [11, 12]}}
{"token": ["Both", "C0012368#ent", "<e1>", "and", "(+)-pindolol", "caused", "marked", "antagonism", "of", "the", "C0001644#ent", "<e2>"], "h": {"id": "C0012368", "name": "C0012368#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [10, 11]}}
{"token": ["In", "order", "to", "develop", "selective", "radioactive", "ligands", "the", "study", "of", "presynaptic", "C0026454#ent", "<e1>", "uptake", "sites", ",", "iodinated", "derivatives", "of", "C0076823#ent", "<e2>", "were", "synthesized", "and", "evaluated", "in", "radioligand", "binding", "assays"], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0076823", "name": "C0076823#ent", "pos": [19, 20]}}
{"token": ["The", "lowering", "of", "serum", "C1704719#ent", "<e1>", "concentration", "was", "significantly", "negatively", "correlated", "with", "the", "severity", "of", "C0018802#ent", "<e2>", "r", "=", "0.6475", ",", "P", "less", "than", "0.001", "."], "h": {"id": "C1704719", "name": "C1704719#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["The", "US", "findings", "are", "of", "no", "help", "in", "distinguishing", "C0041296#ent", "<e1>", "from", "other", "causes", "of", "C0001416#ent", "<e2>", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001416", "name": "C0001416#ent", "pos": [15, 16]}}
{"token": ["C0108178#ent", "<e1>", "in", "macromolecular", "concentrations", "inhibited", "the", "electric", "and", "contractile", "activity", "smooth", "muscle", "cells", "C1539322#ent", "<e2>", ")", "."], "h": {"id": "C0108178", "name": "C0108178#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [14, 15]}}
{"token": ["Aggressive", "antiviral", "therapy", "e.g.", ",", "with", "IF", ")", "followed", "by", "immunostimulation", "(", "e.g.", ",", "with", "C0733383#ent", "<e1>", ")", "may", "prove", "effective", "in", "controlling", "certain", "viral", "infections", "C1334156#ent", "<e2>"], "h": {"id": "C0733383", "name": "C0733383#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334156", "name": "C1334156#ent", "pos": [26, 27]}}
{"token": ["In", "C0156147#ent", "<e1>", "some", "concomitant", "C0221423#ent", "<e2>", "as", "cerebral", "ischemia", "arterial", "or", "venous", "thrombosis", "subacute", "combined", "degeneration", "of", "the", "spinal", "cord", "malabsorption", "of", "vitamin", "B12", "folic", "acid", "opticus", "neuropathy", "and", "polyneuropathy", "have", "been", "described", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [5, 6]}}
{"token": ["In", "this", "regard", ",", "the", "repair", "of", "ischemic", "and", "toxic", "C0525037#ent", "<e1>", "is", "critically", "dependent", "on", "a", "redundant", ",", "interactive", "C1333196#ent", "<e2>", "and", "growth", "factors", "network", "to", "return", "kidney", "function", "near-normal", "baseline", "function", "."], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [20, 21]}}
{"token": ["Nonketotic", "hyperglycinemia", "C0751748#ent", "<e1>", ")", "is", "an", "C3899988#ent", "<e2>", "glycine", "metabolism"], "h": {"id": "C0751748", "name": "C0751748#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}}
{"token": ["C0751748#ent", "<e1>", "NKH", ")", "is", "an", "C3899988#ent", "<e2>", "glycine", "metabolism"], "h": {"id": "C0751748", "name": "C0751748#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [6, 7]}}
{"token": ["Four", "patients", "had", "mainly", "C0001883#ent", "<e1>", "one", "had", "a", "C0035242#ent", "<e2>"], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [9, 10]}}
{"token": ["In", "mucopolysaccharidoses", ",", "C0001883#ent", "<e1>", "multiple", "causative", "factors", "and", "progressive", "C0035242#ent", "<e2>", "severely", "affect", "morbidity", "and", "mortality", "."], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "five", "cisplatin", "response", "genes", "sgkB", ",", "csbA", ",", "C0619938#ent", "<e1>", ",", "smlA", ",", "and", "C3814518#ent", "<e2>", ")", "resulted", "in", "altered", "drug", "sensitivity", "implicating", "novel", "pathways", "in", "cisplatin", "response", "."], "h": {"id": "C0619938", "name": "C0619938#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3814518", "name": "C3814518#ent", "pos": [16, 17]}}
{"token": ["The", "product", "of", "the", "reaction", "between", "sodium", "selenite", "glutathione", ",", "designated", "as", "C0074293#ent", "<e1>", "(", "GSSeSG", ")", ",", "nearly", "completely", "inhibits", "C2917660#ent", "<e2>", "incorporation", "from", "[14C]leucyl-tRNA", "by", "free", "polyribosomes", "isolated", "from", "rat", "liver", "."], "h": {"id": "C0074293", "name": "C0074293#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [21, 22]}}
{"token": ["In", "S.", "cerevisiae", "C3539732#ent", "<e1>", "controls", "the", "expression", "of", "C0017337#ent", "<e2>", "involved", "in", "several", "nutrient-responsive", "biosynthetic", "pathways", "."], "h": {"id": "C3539732", "name": "C3539732#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["Loss-of-function", "mutations", "in", "the", "C3711161#ent", "<e1>", "gene", "locus", "are", "the", "underlying", "cause", "for", "C1704429#ent", "<e2>", "providing", "a", "human", "isolated", "low-HDL", "model", "."], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704429", "name": "C1704429#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "RAD1", "and", "RAD52", "decrease", "the", "ability", "of", "C1704910#ent", "<e1>", "to", "stimulate", "intrachromosomal", "recombination", "mutations", "in", "C3273669#ent", "<e2>", "and", "RAD50", "do", "not", "affect", "C1704910#ent", "<e1>", "activity", "."], "h": {"id": "C3273669", "name": "C3273669#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1704910", "name": "C1704910#ent", "pos": [9, 10]}}
{"token": ["PGF2alpha", "induced", "the", "activities", "of", "extracellular", "signal-regulated", "kinase", "2", "ERK2", ")", "and", "C1367731#ent", "<e1>", "JNK1", ")", "groups", "of", "mitogen-activated", "protein", "kinases", "C2713509#ent", "<e2>", ",", "and", "p70(S6k", ")", "in", "a", "time-dependent", "manner", "in", "growth-arrested", "VSMC", "."], "h": {"id": "C1367731", "name": "C1367731#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [21, 22]}}
{"token": ["One", "family", "member", "C3538745#ent", "<e1>", "(", "also", "known", "as", "C1412079#ent", "<e2>", ")", "functions", "as", "a", "cellular", "efflux", "pump", "anti-HIV", "drugs", "such", "as", "9-(2-phoshoenylmethoxyethyl)", "adenine", "and", "azido-thymidine-monophosphate", ",", "an", "antiviral", "nucleotide", "ganciclovir-monophosphate", ",", "and", "anti-cancer", "agents", "as", "thiopurines", "."], "h": {"id": "C3538745", "name": "C3538745#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412079", "name": "C1412079#ent", "pos": [9, 10]}}
{"token": ["Atypical", "neuroleptics", "are", "associated", "with", "clinical", "significant", "weight", "gain", "whereas", "C0304402#ent", "<e1>", "are", "used", "as", "C0003620#ent", "<e2>", "drugs", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [15, 16]}}
{"token": ["These", "altered", "molecules", "include", "CNS", "C0304402#ent", "<e1>", ",", "potent", "psychomimetics", "(", "hallucinogens", ")", ",", "C0003620#ent", "<e2>", "and", "vasoconstrictors", "that", "all", "have", "the", "basic", "beta-phenylisopropylamine", "skeleton"], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [14, 15]}}
{"token": ["Further", ",", "C1567710#ent", "<e1>", "and", "caspase", "3", "cleavage", "analyses", "confirmed", "C0016365#ent", "<e2>", "mediated", "apoptosis", "at", "molecular", "level"], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0016365", "name": "C0016365#ent", "pos": [10, 11]}}
{"token": ["The", "C1744687#ent", "<e1>", "should", "be", "included", "in", "the", "differential", "diagnosis", "any", "C0009952#ent", "<e2>", "patient", "with", "a", "history", "of", "neuroleptic", "treatment", "."], "h": {"id": "C1744687", "name": "C1744687#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [11, 12]}}
{"token": ["We", "suggest", "that", "the", "molecular", "study", "the", "17p11.2", "region", "be", "an", "effective", "non", "invasive", "tool", "in", "cases", "of", "C0152025#ent", "<e1>", "associated", "with", "episodes", "of", "C0262576#ent", "<e2>"], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0262576", "name": "C0262576#ent", "pos": [24, 25]}}
{"token": ["The", "lipid-soluble", "diaminopyrimidine", ",", "2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine", "(", "C0066142#ent", "<e1>", ")", "binds", "tightly", "to", "C0039667#ent", "<e2>", "has", "antineoplastic", "activity", "man", "and", "several", "animal", "systems"], "h": {"id": "C0066142", "name": "C0066142#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039667", "name": "C0039667#ent", "pos": [12, 13]}}
{"token": ["C0085170#ent", "<e1>", "appears", "to", "be", "a", "particularly", "interesting", "symptomatic", "treatment", "of", "C0009766#ent", "<e2>"], "h": {"id": "C0085170", "name": "C0085170#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [11, 12]}}
{"token": ["Strategies", "for", "the", "control", "of", "human", "C0747256#ent", "<e1>", "as", "onchocerciasis", "and", "C0013884#ent", "<e2>", "an", "understanding", "of", "how", "the", "parasite", "successfully", "infects", "and", "persists", "in", "humans", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0013884", "name": "C0013884#ent", "pos": [11, 12]}}
{"token": ["Side", "effects", "the", "C0013227#ent", "<e1>", "were", "striking", ",", "and", "included", "fever", ",", "hypotension", ",", "C0231528#ent", "<e2>", ",", "bone", "pain", "arthralgia", ",", "arthritis", ",", "abdominal", "pain", "liver", "toxicity", "thrombocytopenia", ",", "and", "neurotoxicity", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [14, 15]}}
{"token": ["The", "C1425013#ent", "<e1>", "95", "also", "decreased", "as", "the", "C0074414#ent", "<e2>", "concentration", "increased", "up", "to", "2.3", "%", "."], "h": {"id": "C1425013", "name": "C1425013#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0074414", "name": "C0074414#ent", "pos": [8, 9]}}
{"token": ["C0175702#ent", "<e1>", "is", "an", "autosomal", "recessive", "neurodegenerative", "disease", "by", "various", "clinical", "manifestations", "as", "diabetes", "mellitus", "C0029124#ent", "<e2>", "diabetes", "insipidus", "deafness", ",", "neurological", "symptoms", "renal", "tract", "abnormalities", "psychiatric", "disorders", "gonadal", "disorders"], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [15, 16]}}
{"token": ["This", "is", "the", "first", "report", "describing", "the", "C1880904#ent", "<e1>", "a", "death", "receptor", "chronic", "disease", "may", "indicate", "that", "a", "C1367453#ent", "<e2>", "receptor-mediated", "signalling", "pathway", "involved", "in", "AD-associated", "neuronal", "loss"], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367453", "name": "C1367453#ent", "pos": [18, 19]}}
{"token": ["Extensive", "cutaneous", "sclerosis", "10", "cases", ",", "C0032339#ent", "<e1>", "in", "seven", "cases", ",", "dysphagia", "in", "three", "cases", ",", "C0034069#ent", "<e2>", "four", "cases", ",", "and", "polyarthralgia", "in", "two", "cases", "."], "h": {"id": "C0032339", "name": "C0032339#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [17, 18]}}
{"token": ["No", "treatment", "differences", "(", "P", ">", ".10", ")", "were", "observed", "for", "C0011685#ent", "<e1>", ",", "ruminal", "particulate", "passage", "rate", ",", "and", "C1367656#ent", "<e2>", "total", "tract", "."], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1367656", "name": "C1367656#ent", "pos": [20, 21]}}
{"token": ["The", "C0011685#ent", "<e1>", "increased", ",", "and", "intake", "of", "C1367656#ent", "<e2>", "and", "crude", "protein", "declined", ",", "as", "the", "allocation", "of", "concentrate", "increased", "."], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367656", "name": "C1367656#ent", "pos": [8, 9]}}
{"token": ["The", "presence", "of", "air", "is", "usually", "asymptomatic", "but", "C0011334#ent", "<e1>", "a", "potential", "risk", "of", "increased", "intracranial", "pressure", "C0025289#ent", "<e2>", "which", "require", "an", "immediate", "therapy", "."], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [17, 18]}}
{"token": ["The", "inverted", "zincin", "motif", ",", "HXXEH", ",", "defines", "the", "inverzincin", "family", "of", "C0021669#ent", "<e1>", "the", "HXXE", "motif", "defines", "the", "C0007075#ent", "<e2>", "and", "the", "HXH", "motif", "DD-carboxypeptidase", "."], "h": {"id": "C0021669", "name": "C0021669#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007075", "name": "C0007075#ent", "pos": [19, 20]}}
{"token": ["A", "postmortem", "examination", "was", "performed", ",", "and", "the", "C1402294#ent", "<e1>", "bilaterally", "severe", ",", "focally", "extensive", "C0006285#ent", "<e2>", "."], "h": {"id": "C1402294", "name": "C1402294#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006285", "name": "C0006285#ent", "pos": [15, 16]}}
{"token": ["The", "C1539715#ent", "<e1>", "C(2)O", ")", "deformation", "band", "appeared", "in", "C1425233#ent", "<e2>", "at", "865", "cm(-1", ")", "for", "EtO", "in", "multilayer", "films", "and", "when", "adsorbed", "in", "the", "monolayer", "at", "terrace", "sites", "."], "h": {"id": "C1539715", "name": "C1539715#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1425233", "name": "C1425233#ent", "pos": [9, 10]}}
{"token": ["C0017668#ent", "<e1>", "FSGH", ")", "presenting", "a", "picture", "of", "glomerulonephritis", "of", "the", "C0950121#ent", "<e2>", "characterized", "morphologically", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0950121", "name": "C0950121#ent", "pos": [11, 12]}}
{"token": ["This", "C0043153#ent", "<e1>", "much", "more", "severe", "than", "the", "myopathy", "that", "occurs", "with", "C0042875#ent", "<e2>", "."], "h": {"id": "C0043153", "name": "C0043153#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042875", "name": "C0042875#ent", "pos": [12, 13]}}
{"token": ["The", "results", ",", "compared", "with", "those", "in", "our", "previous", "report", ",", "show", "that", "the", "D-2", "dopamine", "antagonist", "C0038803#ent", "<e1>", "was", "1000", "times", "more", "potent", "in", "inhibiting", "the", "C0031007#ent", "<e2>", "than", "the", "apomorphine", "rotation", "."], "h": {"id": "C0038803", "name": "C0038803#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031007", "name": "C0031007#ent", "pos": [27, 28]}}
{"token": ["C3273509#ent", "<e1>", "is", "expressed", "C0907533#ent", "<e2>", "to", "a", "high", "level", "in", "most", "tissues", "and", "is", "generally", "more", "abundant", "than", "Hsp90alpha", ",", "whereas", "Hsp90alpha", "is", "stress-inducible", "and", "overexpressed", "in", "many", "cancerous", "cells"], "h": {"id": "C3273509", "name": "C3273509#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [4, 5]}}
{"token": ["A", "study", "of", "20", "patients", "with", "C2987213#ent", "<e1>", "and", "8", "patients", "with", "C0019045#ent", "<e2>", "pregnancy", "is", "presented", "."], "h": {"id": "C2987213", "name": "C2987213#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0019045", "name": "C0019045#ent", "pos": [12, 13]}}
{"token": ["A", "history", "of", "C0398650#ent", "<e1>", "be", "considered", "a", "contraindication", "for", "alpha-interferon", "therapy", "patients", "with", "C0276623#ent", "<e2>"], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0276623", "name": "C0276623#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "elegantin", ",", "which", "shares", "extensive", "sequence", "similarity", "C0124647#ent", "<e1>", "but", "has", "different", "amino", "acids", "the", "tripeptide", "RGD", "preferentially", "inhibited", "platelet", "adhesion", "C2350558#ent", "<e2>", "fibronectin", "as", "opposed", "to", "fibrinogen", "."], "h": {"id": "C0124647", "name": "C0124647#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [24, 25]}}
{"token": ["They", "comprise", "three", "types", "of", "carbonyl", "reductase", "dehydrogenase/reductase", "(", "SDR", "family", ")", "member", "4", ",", "C0909868#ent", "<e1>", "L-xylulose", "reductase", "two", "types", "of", "C1332073#ent", "<e2>", "20alpha-hydroxysteroid", "dehydrogenase", ",", "and", "three", "types", "of", "3alpha-hydroxysteroid", "dehydrogenase", "."], "h": {"id": "C0909868", "name": "C0909868#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332073", "name": "C1332073#ent", "pos": [22, 23]}}
{"token": ["This", "paper", "suggests", "that", "a", "systematic", "medullar", "cytogenetic", "study", "must", "be", "conducted", "in", "the", "case", "of", "any", "refractory", "C0002871#ent", "<e1>", "in", "order", "to", "identify", "the", "C1848862#ent", "<e2>", "5q(-", ")", "in", "individual", "cases"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [25, 26]}}
{"token": ["Phosphatidylinositol", "(", "PI", ")", "3-kinase", "inhibitors", "suppressed", "the", "C1412481#ent", "<e1>", "effect", ",", "while", "apoE", "receptor", "2", "C2987020#ent", "<e2>", ")", "was", "tyrosine", "phosphorylated", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987020", "name": "C2987020#ent", "pos": [16, 17]}}
{"token": ["The", "experiments", "were", "designed", "by", "means", "of", "inhibition", "of", "renal", "DA", "synthesis", "by", "C0006982#ent", "<e1>", "and", "neuronal", "DA", "uptake", "blocked", "by", "C0028277#ent", "<e2>", "."], "h": {"id": "C0006982", "name": "C0006982#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0028277", "name": "C0028277#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "hydroxylated", "flavonoids", "increased", "the", "7-methoxyresorufin", "O-demethylation", "C0000970#ent", "<e1>", "activities", "of", "cDNA-expressed", "human", "C1620185#ent", "<e2>", "and", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [9, 10]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [15, 16]}}
{"token": ["The", "coadministered", "drugs", "used", "in", "the", "study", "were", "ciprofloxacin", ",", "cefixime", ",", "amoxicillin", ",", "metronidazole", ",", "C0051696#ent", "<e1>", ",", "atenolol", ",", "theophylline", ",", "metformin", ",", "C0071097#ent", "<e2>", "and", "glibenclamide", "."], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0071097", "name": "C0071097#ent", "pos": [25, 26]}}
{"token": ["ATM", "(", "ataxia-telangiectasia", "mutated", "is", "necessary", "for", "activation", "of", "Chk1", "by", "C1332120#ent", "<e1>", "(", "ATM", "and", "C3711837#ent", "<e2>", ")", "in", "response", "to", "double-stranded", "DNA", "breaks", "DSBs", ")", "but", "not", "to", "DNA", "replication", "stress"], "h": {"id": "C1332120", "name": "C1332120#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3711837", "name": "C3711837#ent", "pos": [16, 17]}}
{"token": ["The", "nonmethylated", "imprinted", "region", "of", "Igf2", "and", "H19", "was", "resistant", "to", "methylation", "at", "low", "C2348049#ent", "<e1>", "levels", "but", "became", "fully", "methylated", "when", "C2348049#ent", "<e1>", "was", "C3889446#ent", "<e1>", "from", "a", "bacterial", "artificial", "chromosome", "transgene", "."], "h": {"id": "C2348049", "name": "C2348049#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [25, 26]}}
{"token": ["Leigh", "disease", "or", "C0023264#ent", "<e1>", "SNE", ")", ",", "is", "a", "familial", ",", "C0154671#ent", "<e2>", "by", "lesions", "of", "the", "gray", "and", "white", "matter", "the", "brain", "and", "spinal", "cord"], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0154671", "name": "C0154671#ent", "pos": [12, 13]}}
{"token": ["Chickenpox", "occurring", "concurrently", "with", "vaccination", "presents", "no", "problem", "unless", "C0042214#ent", "<e1>", "has", "widely", "superinfected", "the", "C0008049#ent", "<e2>", "lesions", "."], "h": {"id": "C0042214", "name": "C0042214#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008049", "name": "C0008049#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "case", "of", "a", "large", "C0333014#ent", "<e1>", "the", "right", "kidney", "was", "treated", "with", "sulfamethoxazole", "and", "trimethoprim", ",", "and", "C0717400#ent", "<e2>", "."], "h": {"id": "C0333014", "name": "C0333014#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0717400", "name": "C0717400#ent", "pos": [20, 21]}}
{"token": ["Since", "nuclear", "factor-kappaB", "C1417708#ent", "<e1>", ")", "plays", "a", "key", "role", "in", "chronic", "inflammatory", "diseases", "C0035086#ent", "<e2>", "the", "present", "study", "was", "conducted", "to", "elucidate", "the", "role", "of", "C1417708#ent", "<e1>", "in", "the", "pathogenesis", "of", "chronic", "FK506-induced", "nephropathy", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [14, 15]}}
{"token": ["Central", "sleep", "apnea", "syndrome", "C0010592#ent", "<e1>", ")", "occurs", "frequently", "in", "patients", "with", "C0264716#ent", "<e2>", "CHF", ")", "and", "is", "reported", "to", "be", "associated", "with", "poor", "prognosis"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0264716", "name": "C0264716#ent", "pos": [12, 13]}}
{"token": ["Heart", "tissue", "NADPH", "oxidase", "C1417771#ent", "<e1>", ")", "activity", "and", "immunohistochemical", "analysis", "C0599220#ent", "<e2>", "NOX2", ",", "Rac1", ",", "and", "p22(phox", ")", ",", "heart", "tissue", "malondialdehyde", ",", "and", "insulin-stimulated", "protein", "kinase", "B", "Akt", ")", "activation", "were", "measured", "."], "h": {"id": "C1417771", "name": "C1417771#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [11, 12]}}
{"token": ["The", "results", "indicate", "that", "C0035637#ent", "<e1>", "not", "have", "a", "protective", "role", "in", "C0019372#ent", "<e2>"], "h": {"id": "C0035637", "name": "C0035637#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [12, 13]}}
{"token": ["At", "focal", "CNS", "injury", "sites", ",", "several", "cytokines", "accumulate", ",", "including", "C1413557#ent", "<e1>", "CNTF", ")", "and", "C0534519#ent", "<e2>", "(", "IL-1beta", ")", "."], "h": {"id": "C1413557", "name": "C1413557#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [16, 17]}}
{"token": ["Chronic", "granulomatous", "disease", "C3811755#ent", "<e1>", ")", "is", "a", "C0037277#ent", "<e2>", "by", "structural", "mutations", "the", "enzyme", "NADPH", "oxidase", "results", "in", "severe", "immunodeficiency", "."], "h": {"id": "C3811755", "name": "C3811755#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [8, 9]}}
{"token": ["C0012586#ent", "<e1>", ",", "in", "contrast", "to", "the", "C0080151#ent", "<e2>", ",", "is", "effective", "even", "in", "manifest", "prostaglandin", "or", "sympathetic", "hyperalgesia"], "h": {"id": "C0012586", "name": "C0012586#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [7, 8]}}
{"token": ["C0012586#ent", "<e1>", "(", "dipyrone", ")", "and", "other", "nonsteroidal", "anti-inflammatory", "drugs", "C0080151#ent", "<e2>", ")", "induce", "antinociception", "by", "acting", "upon", "peripheral", "tissues", "upon", "central", "nervous", "system", ",", "notably", "the", "periaqueductal", "grey", "matter", "PAG", ")", "and", "the", "spinal", "cord"], "h": {"id": "C0012586", "name": "C0012586#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [10, 11]}}
{"token": ["C0175683#ent", "<e1>", "is", "a", "C0017361#ent", "<e2>", "by", "a", "deficiency", "in", "argininosuccinate", "synthetase", "AS", ")", "."], "h": {"id": "C0175683", "name": "C0175683#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [4, 5]}}
{"token": ["Leaf", "discs", "of", "C.", "intybus", "were", "inoculated", "with", "an", "Agrobacterium", "tumefaciens", "strain", "a", "C0064230#ent", "<e1>", "neo", ")", "gene", "for", "kanamycin", "resistance", "and", "a", "mutant", "acetolactate", "synthase", "gene", "C1425942#ent", "<e2>", "-", "1", ")", "from", "Arabidopsis", "thaliana", "resistance", "to", "sulfonylurea", "herbicides"], "h": {"id": "C0064230", "name": "C0064230#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1425942", "name": "C1425942#ent", "pos": [27, 28]}}
{"token": ["Once", "daily", "oral", "administration", "torasemide", "(", "starting", "with", "5", "mg", ")", "or", "C0016860#ent", "<e1>", "40", "mg", "reduce", "bodyweight", ",", "C0013604#ent", "<e2>", "and", "symptoms", "of", "heart", "failure", "a", "similar", "extent", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [19, 20]}}
{"token": ["We", "have", "isolated", "and", "analyzed", "C1412481#ent", "<e1>", "a", "patient", "with", "C0020476#ent", "<e2>", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [10, 11]}}
{"token": ["We", "have", "isolated", "and", "analyzed", "C1412481#ent", "<e1>", "a", "patient", "with", "C0020476#ent", "<e2>", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [10, 11]}}
{"token": ["C1295392#ent", "<e1>", "GnT-V", ")", "is", "an", "C0027203#ent", "<e2>", "that", "catalyzes", "beta", "1", "6", "branching", "of", "N-acetylglucosamine", "on", "asparagine-linked", "oligosaccharides", "of", "cell", "proteins"], "h": {"id": "C1295392", "name": "C1295392#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [6, 7]}}
{"token": ["C1295392#ent", "<e1>", "GnT-V", ")", ",", "a", "key", "C0027203#ent", "<e2>", "in", "the", "formation", "of", "branching", "of", "asparagine-linked", "oligosaccharides", ",", "is", "strongly", "linked", "to", "tumor", "invasion", "metastasis", "of", "colon", "and", "breast", "cancers"], "h": {"id": "C1295392", "name": "C1295392#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}}
{"token": ["The", "micellar", "properties", "of", "C0029105#ent", "<e1>", ",", "thiopropazate", ",", "flupenthixol", ",", "C0009026#ent", "<e2>", ",", "and", "trifluoperazine", ",", "which", "contain", "a", "piperazine", "moiety", "considerable", "pH", "dependence", "."], "h": {"id": "C0029105", "name": "C0029105#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009026", "name": "C0009026#ent", "pos": [11, 12]}}
{"token": ["Recent", "studies", "in", "vitro", "that", "retinoic", "acid", "C0003873#ent", "<e1>", ")", "downregulates", "the", "release", "of", "C1337092#ent", "<e2>", "and", "TGF-beta1", "by", "tumor", "cells"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C1337092", "name": "C1337092#ent", "pos": [14, 15]}}
{"token": ["To", "evaluate", "the", "clinical", "efficacy", "Ganxian", "recipe", "(", "GXR", ")", "and", "lamivudine", "(", "C3810599#ent", "<e1>", ")", "in", "a", "two-year", "treatment", "of", "C0524909#ent", "<e2>", "CHB", ")", "."], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [21, 22]}}
{"token": ["Neoplastic", "cells", "immunoreactive", "for", "C1421451#ent", "<e1>", "and", "actin", "but", "not", "for", "keratin", ",", "C1413980#ent", "<e2>", ",", "or", "S-100", "protein"], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413980", "name": "C1413980#ent", "pos": [13, 14]}}
{"token": ["Immunohistochemical", "staining", "positivity", "of", "tumour", "cells", "C1421451#ent", "<e1>", ",", "but", "no", "reactivity", "to", "C1413980#ent", "<e2>", ",", "alpha-smooth", "muscle", "actin", "S-100", "protein", "CD34", ",", "or", "AE1/AE3", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413980", "name": "C1413980#ent", "pos": [13, 14]}}
{"token": ["The", "mel-32", "gene", "in", "the", "free", "living", "soil", "nematode", "C0949990#ent", "<e1>", "encodes", "a", "serine", "hydroxymethyltransferase", "C3538858#ent", "<e2>", ")", "isoform", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538858", "name": "C3538858#ent", "pos": [15, 16]}}
{"token": ["The", "gene", "contained", "a", "C1416809#ent", "<e1>", "typical", "conserved", "regions", "of", "C0008145#ent", "<e2>", "reported", "previously", "."], "h": {"id": "C1416809", "name": "C1416809#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008145", "name": "C0008145#ent", "pos": [10, 11]}}
{"token": ["This", "is", "the", "first", "example", "of", "a", "chitin-binding", "protein", "both", "a", "duplication", "of", "the", "43-amino", "acid", "chitin-binding", "domain", "and", "a", "fusion", "of", "the", "C1416809#ent", "<e1>", "a", "structurally", "unrelated", "domain", ",", "the", "C0008145#ent", "<e2>"], "h": {"id": "C1416809", "name": "C1416809#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0008145", "name": "C0008145#ent", "pos": [31, 32]}}
{"token": ["These", "findings", "suggest", "potential", "roles", "for", "basement", "membrane", "the", "C1710463#ent", "<e1>", "tracheal", "epithelial", "C1412828#ent", "<e2>", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412828", "name": "C1412828#ent", "pos": [13, 14]}}
{"token": ["The", "effects", "of", "C0356622#ent", "<e1>", "E(2)", "F(2alpha", ")", "on", "the", "electrofusion", "of", "C1572795#ent", "<e2>", "(", "Pisum", "sativum", "cv", "Ran", "1", ")", "mesophyll", "protoplasts", "were", "examined", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1572795", "name": "C1572795#ent", "pos": [12, 13]}}
{"token": ["The", "force-depressing", "actions", "of", "0.1", "mM", "ALA", "were", "associated", "with", "increased", "cGMP-associated", "vasodilator-stimulated", "phosphoprotein", "C1421428#ent", "<e1>", ")", "phosphorylation", "and", "increased", "sGC", "activity", "in", "homogenates", "of", "C1539312#ent", "<e2>", "cultured", "with", "ALA", "."], "h": {"id": "C1421428", "name": "C1421428#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [25, 26]}}
{"token": ["We", "sought", "to", "compare", "the", "arrhythmic", "risk", "sensitivity", "to", "sympathetic", "stimulation", "of", "mutations", "located", "in", "transmembrane", "regions", "C-terminal", "regions", "the", "KCNQ1", "channel", "the", "C1416612#ent", "<e1>", "form", "of", "C1141890#ent", "<e2>", "LQTS", ")", "."], "h": {"id": "C1416612", "name": "C1416612#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1141890", "name": "C1141890#ent", "pos": [27, 28]}}
{"token": ["Following", "treatment", "of", "mouse", "erythroleukemia", "C1417108#ent", "<e1>", ")", "cells", "with", "C0012403#ent", "<e2>", "other", "typical", "erythroid", "inducing", "agents", ",", "the", "profile", "of", "cellular", "phosphotyrosine-containing", "proteins", "was", "drastically", "altered", "."], "h": {"id": "C1417108", "name": "C1417108#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012403", "name": "C0012403#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "whether", "functional", "genetic", "polymorphisms", "the", "PTGS1", ",", "C1367485#ent", "<e1>", "and", "IL-10", "genes", "influence", "C1836205#ent", "<e2>", "recurrence", "in", "individuals", "participating", "in", "a", "randomized", "aspirin", "intervention", "trial", "."], "h": {"id": "C1367485", "name": "C1367485#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1836205", "name": "C1836205#ent", "pos": [15, 16]}}
{"token": ["C0356622#ent", "<e1>", "such", "as", "PGE2", "and", "C0072261#ent", "<e2>", "and", "free", "radicals", "some", "of", "the", "agents", "released", "during", "inflammatory", "reactions", "and", "they", "are", "neurotoxic", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072261", "name": "C0072261#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", "the", "indiscriminated", "consumption", "of", "M.", "uniflora", "pharmaceutical", "products", "to", "the", "nutritional", "deficiency", "C0885449#ent", "<e1>", "might", "contribute", "to", "the", "development", "of", "C3665349#ent", "<e2>", "and", "goiter", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [24, 25]}}
{"token": ["We", "have", "tested", "C1417756#ent", "<e1>", "in", "a", "pilot", "study", "12", "patients", "with", "C0019693#ent", "<e2>", "of", "whom", "6", "underwent", "C1417756#ent", "<e1>", "."], "h": {"id": "C1417756", "name": "C1417756#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [12, 13]}}
{"token": ["Finally", "C0054065#ent", "<e1>", "was", "shown", "not", "to", "elevate", "C1418938#ent", "<e2>", "a", "dose", "of", "5", "mg", ",", "a", "finding", "consistent", "with", "of", "dopamine", "receptor", "antagonism", "."], "h": {"id": "C0054065", "name": "C0054065#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "show", "that", "the", "proprotein", "convertases", "C0919550#ent", "<e1>", "and", "Spc4", "(", "also", "known", "as", "C0919550#ent", "<e1>", "and", "Pace4", ",", "respectively", ")", "are", "expressed", "in", "adjacent", "extraembryonic", "ectoderm", "."], "h": {"id": "C0919550", "name": "C0919550#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [7, 8]}}
{"token": ["In", "64", "patients", "with", "Parkinson's", "disease", "C1335499#ent", "<e1>", ")", ",", "the", "basal", "level", "of", "C1418938#ent", "<e2>", "(", "PRL", ")", "was", "normal", "."], "h": {"id": "C1335499", "name": "C1335499#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [14, 15]}}
{"token": ["None", ",", "however", ",", "had", "HSV", "isolated", "from", "the", "throat", "at", "the", "time", "of", "the", "C0014921#ent", "<e1>", "or", "from", "an", "C0014921#ent", "<e1>", "C0037284#ent", "<e1>"], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [22, 23]}}
{"token": ["The", "C1323099#ent", "<e1>", "potency", "of", "C0022614#ent", "<e2>", "is", "one", "of", "the", "most", "significant", "pharmacological", "features", "of", "the", "substance", "with", "direct", "clinical", "implications", "."], "h": {"id": "C1323099", "name": "C1323099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [5, 6]}}
{"token": ["This", "report", "examines", "the", "role", "of", "C0087140#ent", "<e1>", "in", "growth", "factor", "stimulation", "of", "C1366358#ent", "<e2>", ",", "a", "matrix-degrading", "secreted", "metalloproteinase", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366358", "name": "C1366358#ent", "pos": [13, 14]}}
{"token": ["Losartan", ",", "an", "Ang", "II", "receptor", "1", "blocker", "and", "C0054836#ent", "<e1>", ",", "an", "alpha1-nonselective-beta1,2,3-adrenergic", "blocker", ",", "but", "not", "C1569495#ent", "<e2>", ",", "an", "alpha1-selective-adrenergic", "blocker", ",", "lowered", "glycerol", "and", "norepinephrine", "levels", ",", "preventing", "lipolysis", "and", "weight", "loss"], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1569495", "name": "C1569495#ent", "pos": [18, 19]}}
{"token": ["Urine", "sediment", ",", "however", ",", "C0038760#ent", "<e1>", "only", "one", "urine", "fraction", "the", "C0081437#ent", "<e2>"], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0081437", "name": "C0081437#ent", "pos": [12, 13]}}
{"token": ["The", "CHO", "cell", "line", "yielded", "many", "recessive", "mutations", "including", ",", "for", "example", ",", "C1823514#ent", "<e1>", ",", "a", "temperature", "sensitive", "C0023414#ent", "<e2>", "mutant", ",", "which", "under", "non-permissive", "conditions", "rapidly", "shuts", "down", "protein", "synthesis", "generates", "uncharged", "tRNA"], "h": {"id": "C1823514", "name": "C1823514#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023414", "name": "C0023414#ent", "pos": [19, 20]}}
{"token": ["Phytophotodermatitis", "(", "PPD", ")", "is", "a", "C0162830#ent", "<e1>", "occurs", "when", "the", "skin", "comes", "in", "contact", "with", "a", "C0162713#ent", "<e2>", "and", "is", "subsequently", "exposed", "to", "radiation", "."], "h": {"id": "C0162830", "name": "C0162830#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162713", "name": "C0162713#ent", "pos": [17, 18]}}
{"token": ["This", "coincided", "with", "correspondingly", "altered", "phosphorylation", "of", "the", "extracellular-regulated", "protein", "kinase", "1/2", "ERK", "1/2", ")", ",", "p70S6", "kinase", "(", "C1136240#ent", "<e1>", ",", "eukaryotic", "elongation", "factor", "2", "C0059037#ent", "<e2>", ")", "kinase", "and", "C0059037#ent", "<e2>", "."], "h": {"id": "C1136240", "name": "C1136240#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [26, 27]}}
{"token": ["Mutations", "in", "the", "C1705972#ent", "<e1>", "in", "xeroderma", "pigmentosum", "XP", ")", "and", "C1955934#ent", "<e2>", "(", "TTD", ")", ",", "the", "phenotypes", "of", "which", "are", "often", "intricate", "."], "h": {"id": "C1705972", "name": "C1705972#ent", "pos": [3, 4]}, "relation": "gene_associated_with_disease", "t": {"id": "C1955934", "name": "C1955934#ent", "pos": [11, 12]}}
{"token": ["Conversion", "of", "Lys-Lys", "and", "Lys-Arg", "sequences", "to", "Lys-Gln", "and", "of", "Arg-Arg", "to", "C3657851#ent", "<e1>", "altered", "initial", "C3470489#ent", "<e2>", "processing", "at", "only", "three", "of", "the", "putative", "processing", "sites"], "h": {"id": "C3657851", "name": "C3657851#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3470489", "name": "C3470489#ent", "pos": [16, 17]}}
{"token": ["A", "59-year-old", "man", "showed", "asynchronous", "development", "of", "noninfectious", "granulomatous", "aortitis", "with", "C0751003#ent", "<e1>", ",", "followed", "9", "months", "later", "by", "pulmonary", "capillaritis", "C0017658#ent", "<e2>", "in", "association", "with", "elevated", "serum", "antineutrophil", "cytoplasmic", "antibody", "."], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [21, 22]}}
{"token": ["In", "C0154694#ent", "<e1>", "the", "characteristic", "C3813556#ent", "<e2>", "revealed", "asymmetrical", "ventricular", "dilatation", "cortical", "atrophy", "localized", "low", "density", "areas", "in", "the", "cerebral", "hemisphere", "contralateral", "to", "the", "palsy", "."], "h": {"id": "C0154694", "name": "C0154694#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [5, 6]}}
{"token": ["C1419407#ent", "<e1>", "and", "TCL", "C0030956#ent", "<e2>", "appeared", "to", "affect", "the", "headgroup", "orientation", "similarly", "to", "K(6", ")", ",", "although", "the", "perturbations", "were", "weaker", "and", "unlike", "those", "induced", "by", "the", "Cdc42", "peptide", "R(6", ")", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}}
{"token": ["To", "determine", "whether", "C1419407#ent", "<e1>", "directly", "modulates", "RhoA-associated", "myofibroblast", "differentiation", "mesangial", "cells", "transduced", "with", "inhibitory", "C0030956#ent", "<e2>", "to", "human", "immunodeficiency", "virus-Tat", ",", "resulting", "in", "enhanced", "alpha-smooth", "muscle", "organization", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [15, 16]}}
{"token": ["Inflammatory", "conditions", "the", "gastrointestinal", "and", "C4054251#ent", "<e1>", "liver", "such", "as", "Barrett", "esophagus", "Helicobacter", "pylori", "gastritis", "inflammatory", "bowel", "disease", "C0042721#ent", "<e2>", "are", "associated", "with", "increased", "frequency", "of", "malignancies", "and", "CpG", "methylation"], "h": {"id": "C4054251", "name": "C4054251#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [18, 19]}}
{"token": ["We", "report", "three", "patients", "with", "C1832615#ent", "<e1>", "associated", "with", "hypercalcaemia", "and", "severe", "C0020502#ent", "<e2>", "with", "related", "skeletal", "demineralisation", "."], "h": {"id": "C1832615", "name": "C1832615#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0020502", "name": "C0020502#ent", "pos": [12, 13]}}
{"token": ["Intravenous", "injection", "of", "New", "Zealand", "White", "rabbits", "type", "III", "pneumococcal", "polysaccharide", "vaccine", "conjugated", "with", "the", "C3536854#ent", "<e1>", "digoxin", "resulted", "in", "the", "production", "of", "both", "C0025132#ent", "<e2>", "and", "anti-type", "III", "pneumococcal", "polysacharide", "antibodies", "."], "h": {"id": "C3536854", "name": "C3536854#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025132", "name": "C0025132#ent", "pos": [24, 25]}}
{"token": ["Mutants", "of", "Escherichia", "coli", "C1413932#ent", "<e1>", "were", "generated", "by", "site-directed", "mutagenesis", "explore", "the", "molecular", "mechanism", "this", "C0014442#ent", "<e2>", "."], "h": {"id": "C1413932", "name": "C1413932#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["Proliferation", "of", "adipose", "and", "fibrous", "connective", "tissue", "present", "in", "various", "C0027868#ent", "<e1>", "is", "remarkably", "abundant", "in", "those", "C0026848#ent", "<e2>", "associated", "with", "degenerative", "changes", ",", "such", "as", "the", "muscular", "dystrophies", "inflammatory", "myopathies", "chronic", "forms", "motor", "neuron", "diseases"], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [17, 18]}}
{"token": ["C0027868#ent", "<e1>", "in", "the", "ICU", "can", "be", "categorized", "as", "C0026848#ent", "<e2>", "lead", "to", "ICU", "admission", "those", "that", "are", "acquired", "in", "the", "ICU", "."], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [9, 10]}}
{"token": ["ANP", "significantly", "increased", "phagocytotic", "activity", "of", "C1855648#ent", "<e1>", "via", "NPR-A.", "No", "effect", "ANP", "on", "LPS-activated", "inducible", "nitric", "oxide", "synthase", "C1968833#ent", "<e2>", ")", "and", "cyclooxygenase-2", "protein", "levels", "C1968833#ent", "<e2>", "mRNA", "expression", ",", "nitric", "oxide", "and", "PGE2-production", "was", "observed", "."], "h": {"id": "C1855648", "name": "C1855648#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "by", "analyzing", "multiple", "promoter", "elements", "reporter", "assays", ",", "we", "have", "shown", "that", "C1431671#ent", "<e1>", "is", "implicated", "in", "the", "activation", "of", "the", "C0812246#ent", "<e2>", "promoter", "."], "h": {"id": "C1431671", "name": "C1431671#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [24, 25]}}
{"token": ["GRGDSP", "and", "cytochalasin", "B", "levels", "of", "membrane-associated", "pro-", "and", "active", "form", "C2001899#ent", "<e1>", "and", "MMP-2", "but", "not", "C1569872#ent", "<e2>", ",", "stimulated", "cell", "surface", "MMP-1", "staining", "induced", "that", "of", "C1569872#ent", "<e2>", ",", "MMP-2", "and", "TIMP-2", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1569872", "name": "C1569872#ent", "pos": [17, 18]}}
{"token": ["Parietal", "perfusion", "deficits", "in", "C0242422#ent", "<e1>", "patients", "resemble", "those", "described", "in", "C0002395#ent", "<e2>"], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [11, 12]}}
{"token": ["Similar", "measurements", "were", "made", "in", "postmortem", "tissues", "of", "12", "control", "and", "13", "demented", "C0242422#ent", "<e1>", "patients", "who", "had", "had", "C0002395#ent", "<e2>", "cortical", "pathology", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}}
{"token": ["Consistent", "with", "constitutive", "endocytosis", "reported", "for", "C1332708#ent", "<e1>", ",", "the", "probes", "are", "internalized", "once", "bound", ",", "demonstrating", "that", "C1332708#ent", "<e1>", "is", "an", "C3537377#ent", "<e1>", "can", "carry", "ligand-decorated", "\"", "cargo", "\"", "to", "intracellular", "compartments", "."], "h": {"id": "C1332708", "name": "C1332708#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3537377", "name": "C3537377#ent", "pos": [22, 23]}}
{"token": ["Since", "C0085208#ent", "<e1>", "has", "no", "functional", "group", "can", "be", "easily", "derivatized", ",", "a", "C0063242#ent", "<e2>", "group", "was", "incorporated", "into", "the", "molecule", "."], "h": {"id": "C0085208", "name": "C0085208#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0063242", "name": "C0063242#ent", "pos": [13, 14]}}
{"token": ["We", "defined", "two", "regions", "of", "IL-5R", "alpha", "the", "IL-5-induced", "proliferative", "response", ",", "the", "expression", "of", "C1366517#ent", "<e1>", "and", "the", "tyrosine", "phosphorylation", "cellular", "proteins", "beta", "c", "SH2/SH3-containing", "proteins", "and", "C1527617#ent", "<e2>"], "h": {"id": "C1366517", "name": "C1366517#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1527617", "name": "C1527617#ent", "pos": [28, 29]}}
{"token": ["The", "time", "at", "which", "the", "N-ethylmaleimide-sensitive", "factor", "C1417857#ent", "<e1>", ")", "acts", "during", "synaptic", "vesicle", "SV", ")", "trafficking", "was", "identified", "by", "C3275244#ent", "<e2>", "perturbation", "of", "C1417857#ent", "<e1>", "function", "with", "a", "photoactivatable", "inhibitory", "peptide", "."], "h": {"id": "C3275244", "name": "C3275244#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1417857", "name": "C1417857#ent", "pos": [7, 8]}}
{"token": ["Mutations", "in", "the", "CFTR", "gene", "result", "in", "cystic", "fibrosis", "characterized", "by", "severe", "pathology", "(", "e.g.", "recurrent", "C0024116#ent", "<e1>", "male", "infertility", "and", "C0030293#ent", "<e2>", "involving", "organs", "expressing", "the", "CFTR", "."], "h": {"id": "C0024116", "name": "C0024116#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030293", "name": "C0030293#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "the", "glycosylated", "enzyme", "is", "less", "susceptible", "to", "C1412322#ent", "<e1>", "such", "as", "sorbinil", "and", "C0051486#ent", "<e2>", "."], "h": {"id": "C1412322", "name": "C1412322#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0051486", "name": "C0051486#ent", "pos": [16, 17]}}
{"token": ["The", "inhibition", "of", "C1412322#ent", "<e1>", "a", "human", "source", "by", "C0051486#ent", "<e2>", "was", "studied", "."], "h": {"id": "C1412322", "name": "C1412322#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0051486", "name": "C0051486#ent", "pos": [9, 10]}}
{"token": ["The", "Christ-Siemens-Touraine", "syndrome", "CST", "syndrome", "is", "the", "rare", "an-", "or", "C0020620#ent", "<e1>", "form", "of", "the", "C0162359#ent", "<e2>"], "h": {"id": "C0020620", "name": "C0020620#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0162359", "name": "C0162359#ent", "pos": [15, 16]}}
{"token": ["We", "have", "located", "an", "intergenic", "region", "is", "between", "the", "C1332725#ent", "<e1>", "MM1314", ")", "and", "the", "C0017337#ent", "<e2>", "for", "an", "adjacent", "protein", "(", "MM1315", ")", ",", "which", "shows", "strong", "characteristics", "of", "the", "known", "replication", "origins"], "h": {"id": "C1332725", "name": "C1332725#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["Experiments", "were", "undertaken", "to", "test", "the", "hypothesis", "that", "the", "p24/CD9", "cell", "surface", "molecule", "(", "originally", "detected", "on", "acute", "lymphoblastic", "leukemia", "cells", "and", "the", "C0080058#ent", "<e1>", "encoded", "by", "the", "C1335597#ent", "<e2>", "related", "."], "h": {"id": "C0080058", "name": "C0080058#ent", "pos": [23, 24]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335597", "name": "C1335597#ent", "pos": [28, 29]}}
{"token": ["Abnormal", "responses", "of", "serum", "prolactin", "PRL", ")", "to", "luteinizing", "hormone-releasing", "hormone", "LHRH", ")", "stimulation", "have", "been", "observed", "in", "C0429468#ent", "<e1>", "women", "and", "in", "C0271623#ent", "<e2>", "patients", "."], "h": {"id": "C0429468", "name": "C0429468#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [23, 24]}}
{"token": ["Pretreatment", "of", "tissues", "with", "either", "the", "C0001641#ent", "<e1>", "phentolamine", "or", "the", "beta-adrenergic", "receptor", "antagonist", "propranolol", "prevented", "the", "action", "of", "C0026454#ent", "<e2>", "."], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "the", "prevalence", "and", "clinical", "correlation", "of", "autoantibody", "to", "peroxiredoxin", "(", "Prx", ")", "I", ",", "an", "C0633225#ent", "<e1>", "in", "patients", "with", "C1290138#ent", "<e2>", "SSc", ")", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [22, 23]}}
{"token": ["Longer-acting", "analogues", "of", "C1881011#ent", "<e1>", "will", "be", "needed", "before", "long-term", "therapy", "of", "C0001206#ent", "<e2>", "or", "diabetes", "mellitus", "possible", ",", "but", "such", "preparations", "should", "be", "available", "soon", "for", "clinical", "trial"], "h": {"id": "C1881011", "name": "C1881011#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [12, 13]}}
{"token": ["We", "hypothesized", "that", "arterial", "stiffness", "the", "central", "artery", "be", "more", "closely", "associated", "with", "C0151744#ent", "<e1>", "IHD", ")", "than", "stiffness", "of", "peripheral", "arteries", "C0011854#ent", "<e2>"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [22, 23]}}
{"token": ["In", "RALA255", "-", "10", "G", "cells", "optimal", "C0031644#ent", "<e1>", "gene", "expression", "required", "the", "simultaneous", "presence", "of", "C0011816#ent", "<e2>", ",", "retinoic", "acid", "and", "Bt2cAMP", ";", "C0011816#ent", "<e2>", "had", "to", "be", "present", "at", "all", "times", "."], "h": {"id": "C0031644", "name": "C0031644#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [16, 17]}}
{"token": ["These", "results", "demonstrate", "that", "C2", "increases", "C/EBP", "beta-mediated", "COX-2", "induction", "by", "LPS", "and", "that", "the", "pathway", "of", "C1705632#ent", "<e1>", "but", "not", "ERK1/2", "is", "responsible", "for", "C1413947#ent", "<e2>", "activator", "protein-1-mediated", "C/EBP", "beta", "expression", "."], "h": {"id": "C1705632", "name": "C1705632#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413947", "name": "C1413947#ent", "pos": [25, 26]}}
{"token": ["Lung", "transplantation", "become", "a", "viable", ",", "although", "highly", "C1367457#ent", "<e1>", ",", "option", "for", "select", "patients", "with", "C0022661#ent", "<e2>"], "h": {"id": "C1367457", "name": "C1367457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [16, 17]}}
{"token": ["C0017661#ent", "<e1>", "the", "most", "common", "form", "of", "C0268784#ent", "<e2>", "and", "also", "one", "of", "the", "major", "determinants", "of", "a", "patient's", "prognosis", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268784", "name": "C0268784#ent", "pos": [7, 8]}}
{"token": ["We", "identified", "two", "homoplasmic", "mtDNA", "mutations", "at", "the", "positions", "of", "3394", "(", "T-C", ")", "and", "3423", "(", "G-T", ")", "in", "a", "C0011860#ent", "<e1>", "patient", "with", "clinical", "features", "of", "C0162666#ent", "<e2>"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0162666", "name": "C0162666#ent", "pos": [28, 29]}}
{"token": ["Symptomatic", "treatment", "with", "C0728960#ent", "<e1>", "is", "often", "unavoidable", "in", "patients", "with", "C0149521#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [11, 12]}}
{"token": ["Incubation", "of", "normal", "mouse", "cells", "consisting", "of", "over", "90", "%", "phagocytizing", "macrophages", "with", "delta", "9-tetrahydrocannabinol", "C1839163#ent", "<e1>", ")", "resulted", "in", "a", "inhibition", "of", "C0031306#ent", "<e2>"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031306", "name": "C0031306#ent", "pos": [23, 24]}}
{"token": ["Possible", "seasonal", "variations", "the", "C0020615#ent", "<e1>", "property", "of", "Opuntia", "streptacantha", ",", "were", "studied", "using", "the", "fresh", "C2699241#ent", "<e2>", "of", "its", "stems", "collected", "throughout", "the", "year", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2699241", "name": "C2699241#ent", "pos": [16, 17]}}
{"token": ["This", "paper", "describes", "the", "treatment", "of", "58", "patients", "with", "C0001144#ent", "<e1>", ",", "including", "30", "patients", "treated", "with", "%", "C0005088#ent", "<e2>", "28", "patients", "treated", "with", "%", "retinoic", "acid", "ointment", "as", "control", "."], "h": {"id": "C0001144", "name": "C0001144#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0005088", "name": "C0005088#ent", "pos": [18, 19]}}
{"token": ["In", "these", "changes", "we", "observed", "no", "characteristics", "which", "distinguish", "DAO-aminobenzoate", "complexes", "from", "DAO-benzoate", "complex", ",", "even", "though", "o-", ",", "m-", ",", "and", "C3266846#ent", "<e1>", "are", "known", "to", "form", "charge-transfer", "complexes", "C1412100#ent", "<e2>", "."], "h": {"id": "C3266846", "name": "C3266846#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1412100", "name": "C1412100#ent", "pos": [30, 31]}}
{"token": ["A", "case", "of", "C1839163#ent", "<e1>", "caused", "by", "C0034239#ent", "<e2>", "is", "reported", "in", "a", "patient", "receiving", "chemotherapy", "for", "pulmonary", "tuberculosis"], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034239", "name": "C0034239#ent", "pos": [7, 8]}}
{"token": ["Desmin", "is", "a", "C1540067#ent", "<e1>", "a", "constitutive", "subunit", "of", "the", "C1334214#ent", "<e2>", "IF", ")", "in", "skeletal", ",", "cardiac", "and", "smooth", "muscles"], "h": {"id": "C1540067", "name": "C1540067#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334214", "name": "C1334214#ent", "pos": [10, 11]}}
{"token": ["The", "C0037763#ent", "<e1>", "that", "were", "tested", "also", "cleaved", "113", "kDa", "C1709384#ent", "<e2>", "to", "an", "89-kDa", "fragment", "through", "Western", "blot", "assay", "suggesting", "the", "activation", "of", "caspase-3", "and/or", "caspase-7", "in", "the", "Jurkat", "T", "cell"], "h": {"id": "C0037763", "name": "C0037763#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1709384", "name": "C1709384#ent", "pos": [10, 11]}}
{"token": ["Twenty", "four", "patients", "with", "drug", "resistant", "C0014547#ent", "<e1>", "were", "given", "C0024002#ent", "<e2>", "and", "placebo", "added", "to", "their", "pre-existing", "drug", "regime", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [10, 11]}}
{"token": ["C0009014#ent", "<e1>", "significantly", "increased", "the", "amount", "of", "peripheral", "heating", "to", "provoke", "a", "C0600142#ent", "<e2>", "40.6", "versus", "33.6", "minutes", ")", "and", "reduced", "the", "number", "of", "hot", "flushes", "did", "occur", "(", "two", "versus", "eight", ")", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0600142", "name": "C0600142#ent", "pos": [12, 13]}}
{"token": ["C1567710#ent", "<e1>", "activation", "contributes", "to", "endothelial", "cell", "dysfunction", "appears", "to", "be", "the", "C0127400#ent", "<e2>", "all", "the", "mechanisms", "by", "which", "hyperglycaemia-induces", "diabetic", "vascular", "dysfunction", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [12, 13]}}
{"token": ["Surprisingly", ",", "we", "also", "found", "that", "phosphatidic", "acid", "PA", ")", ",", "the", "hydrolysis", "product", "of", "C0031670#ent", "<e1>", "was", "also", "produced", "in", "intact", "PMN", "following", "C0538269#ent", "<e2>", "exposure", "."], "h": {"id": "C0031670", "name": "C0031670#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0538269", "name": "C0538269#ent", "pos": [24, 25]}}
{"token": ["C0597094#ent", "<e1>", "and", "primer", "extension", "experiments", "indicate", "that", "the", "transcription", "initiation", "site", "the", "C1423060#ent", "<e2>", "mRNA", "coincides", "with", "the", "GUG", "translation", "initiation", "codon", "of", "the", "hisD", "cistron", "."], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423060", "name": "C1423060#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "have", "cloned", "a", "cDNA", "and", "analyzed", "the", "C0079429#ent", "<e1>", "for", "human", "C1426589#ent", "<e2>", "by", "polymerase", "chain", "reaction-based", "strategies", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1426589", "name": "C1426589#ent", "pos": [13, 14]}}
{"token": ["To", "compare", "the", "ability", "of", "two", "different", "dedicated", "extremity", "MRI", "E-MRI", ")", "units", "and", "conventional", "radiography", "CR", ")", "for", "identifying", "bone", "erosions", "C0038013#ent", "<e1>", "RA", ")", "metacarpophalangeal", "(", "C4283801#ent", "<e2>", ")", "and", "wrist", "joints"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [28, 29]}}
{"token": ["Some", "epidemiological", ",", "clinical", "and", "experimental", "studies", "shown", "that", "intake", "of", "n-3", "fatty", "acids", "C3469521#ent", "<e1>", ")", "lowers", "the", "incidence", "of", "C0010054#ent", "<e2>", "CHD", ")", "."], "h": {"id": "C3469521", "name": "C3469521#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [21, 22]}}
{"token": ["Exogenous", "C0037537#ent", "<e1>", "(", "GHB", ")", "increases", "slow-wave", "sleep", "reduces", "daytime", "sleepiness", "C0007384#ent", "<e2>", "in", "patients", "with", "primary", "narcolepsy"], "h": {"id": "C0037537", "name": "C0037537#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0007384", "name": "C0007384#ent", "pos": [12, 13]}}
{"token": ["Horseradish", "peroxidase", "C3889156#ent", "<e1>", ")", "catalyzes", "the", "reduction", "of", "iodine", "to", "iodide", "by", "C0013618#ent", "<e2>", "with", "pseudocatalatic", "degradation", "of", "H2O2", "to", "O2", "(", "Banerjee", "et", "al.", ",", "(", "1986", ")", "J.", "Biol", "."], "h": {"id": "C3889156", "name": "C3889156#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [13, 14]}}
{"token": ["The", "oxene", "donor", "iodosobenzene", "and", "hydrogen", "peroxide", "a", "spectral", "intermediate", "to", "the", "complex", "observed", "with", "prostaglandin", "G2", "arachidonic", "acid", "C3890009#ent", "<e1>", "seminal", "vesicle", "microsomes", "as", "well", "as", "with", "the", "purified", "C0033551#ent", "<e2>"], "h": {"id": "C3890009", "name": "C3890009#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [30, 31]}}
{"token": ["Compound", "44", "highly", "selective", "for", "5-LO", "when", "compared", "to", "the", "inhibition", "of", "human", "FLAP", ",", "porcine", "12-LO", ",", "and", "also", "C3890009#ent", "<e1>", "seminal", "vesicle", "C0033551#ent", "<e2>", "."], "h": {"id": "C3890009", "name": "C3890009#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [24, 25]}}
{"token": ["Kikuchi's", "lymphadenitis", "C1366480#ent", "<e1>", ";", "histiocytic", "necrotizing", "lymphadenitis", "granulocytic", "infiltration", "is", "a", "generally", "benign", ",", "C0743841#ent", "<e2>", "unknown", "aetiology", "with", "distinct", "histological", "features", "."], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0743841", "name": "C0743841#ent", "pos": [15, 16]}}
{"token": ["Concomitant", "C1413599#ent", "<e1>", "deficiency", "in", "patients", "with", "C0021053#ent", "<e2>", "been", "associated", "with", "increased", "susceptibility", "to", "complicating", "infections", "that", "may", "hasten", "disease", "progression"], "h": {"id": "C1413599", "name": "C1413599#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [7, 8]}}
{"token": ["The", "deduced", "protein", "showed", "no", "transmembrane", "domain", "67", "%", "alpha-helix", "content", ",", "a", "mutated", "calcium-binding", "site", "EF-hand", "motif", ",", "four", "putative", "\"", "C0079686#ent", "<e1>", "motifs", ",", "and", "a", "C1709139#ent", "<e2>"], "h": {"id": "C0079686", "name": "C0079686#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1709139", "name": "C1709139#ent", "pos": [28, 29]}}
{"token": ["We", "propose", "that", "C1705633#ent", "<e1>", "contributes", "to", "enhancing", "C2982484#ent", "<e2>", "activity", ",", "thereby", "increasing", "glucose", "uptake"], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [8, 9]}}
{"token": ["C1705633#ent", "<e1>", "inhibition", "increased", "GLUT1", "protein", "and", "prevented", "the", "loss", "of", "C2982484#ent", "<e2>", "."], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [11, 12]}}
{"token": ["Subsequent", "matrix-assisted", "laser", "desorption", "ionization/time", "flight", "analysis", "identified", "10", "proteins", ",", "including", "beta-lactate", "dehydrogenase", "Rho", "GDP", "dissociation", "inhibitor", "beta", "C0004199#ent", "<e1>", "elongation", "factor", "2", "protein", "disulfide", "isomerase", "nucleophosmin-1", ",", "chaperonin", ",", "actin", ",", "C0908145#ent", "<e2>", "PTP1B", ")", ",", "and", "glucosidase", "II"], "h": {"id": "C0004199", "name": "C0004199#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0908145", "name": "C0908145#ent", "pos": [33, 34]}}
{"token": ["Because", "similar", "mutations", "in", "C1334489#ent", "<e1>", "and", "mcm4", "can", "not", "bypass", "DDK", ",", "C1334492#ent", "<e2>", "be", "a", "unique", "Mcm", "protein", "is", "the", "final", "target", "of", "DDK", "regulation", "."], "h": {"id": "C1334489", "name": "C1334489#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334492", "name": "C1334492#ent", "pos": [13, 14]}}
{"token": ["C1858028#ent", "<e1>", "an", "autosomal", "recessive", "neurodegenerative", "disorder", "by", "diabetes", "insipidus", "C0011849#ent", "<e2>", "(", "nonautoimmune", ")", ",", "optic", "atrophy", "and", "deafness", "(", "a", "set", "of", "conditions", "referred", "to", "as", "DIDMOAD", ")", "."], "h": {"id": "C1858028", "name": "C1858028#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}}
{"token": ["Results", "from", "C0537086#ent", "<e1>", "the", "association", "of", "C0079423#ent", "<e2>", "with", "p53", "in", "extracts", "containing", "Sp1", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079423", "name": "C0079423#ent", "pos": [7, 8]}}
{"token": ["It", "had", "been", "described", "that", "the", "histopathology", "and", "the", "reaction", "to", "C0012191#ent", "<e1>", "treatment", "of", "this", "model", "closely", "resemble", "human", "C0029001#ent", "<e2>", "."], "h": {"id": "C0012191", "name": "C0012191#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029001", "name": "C0029001#ent", "pos": [20, 21]}}
{"token": ["The", "latter", "fragment", "encoded", "a", "C0005244#ent", "<e1>", "which", "can", "bind", "C0086140#ent", "<e2>"], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [10, 11]}}
{"token": ["The", "enzyme", "behaved", "primarily", "as", "penicillinase", "and", "apparent", "Km", "value", "benzylpenicillin", "was", "500", "microM.", "The", "C0005244#ent", "<e1>", "of", "S.", "cellulosae", "interacted", "strongly", "with", "C0086140#ent", "<e2>", "NADP+-agarose", "but", "not", "with", "Sepharose", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [23, 24]}}
{"token": ["Only", "the", "group", "with", "axial", "disease", "sacroiliitis+spondylitis", ")", "without", "C0027813#ent", "<e1>", "not", "fulfilling", "the", "NY", "criteria", "a", "truly", "increased", "C1537935#ent", "<e2>", "prevalence", "."], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1537935", "name": "C1537935#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "a", "preliminary", "tertiary-structure", "model", "is", "reported", ",", "showing", "that", "the", "overall", "folding", "of", "mBS-RNase", "is", "closer", "to", "that", "of", "C0035542#ent", "<e1>", "than", "that", "of", "(", "dimeric", ")", "C0107298#ent", "<e2>", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0107298", "name": "C0107298#ent", "pos": [29, 30]}}
{"token": ["In", "the", "C0035542#ent", "<e1>", "dimericity", "is", "a", "unique", "feature", "of", "bovine", "seminal", "RNase", "C0107298#ent", "<e2>", ")", "."], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0107298", "name": "C0107298#ent", "pos": [13, 14]}}
{"token": ["CAK", "beta", "localized", "to", "sites", "of", "cell-to-cell", "contact", "in", "COS-7", "transfected", "with", "C1430595#ent", "<e1>", "in", "which", "C1565427#ent", "<e2>", "was", "found", "at", "the", "bottom", "of", "the", "cells", "."], "h": {"id": "C1430595", "name": "C1430595#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [16, 17]}}
{"token": ["fakB", "is", "thus", "a", "C1430595#ent", "<e1>", "that", "is", "differentially", "regulated", "from", "that", "of", "C1565427#ent", "<e2>", "and", "likely", "plays", "a", "role", "in", "antigen-induced", "lymphocyte", "signaling", "."], "h": {"id": "C1430595", "name": "C1430595#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [13, 14]}}
{"token": ["The", "same", "applies", "to", "liposomally", "encapsulated", "C0546862#ent", "<e1>", "with", "respect", "to", "C0040259#ent", "<e2>"], "h": {"id": "C0546862", "name": "C0546862#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [11, 12]}}
{"token": ["Minimal", "change", "C0027726#ent", "<e1>", "a", "rare", "type", "of", "C0022658#ent", "<e2>", "and", "successful", "remission", "may", "require", "therapeutic", "resection", "the", "underlying", "tumor", ",", "or", "administration", "of", "a", "vascular", "endothelial", "growth", "factor", "antagonist", "the", "tumor", "is", "unresectable", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [8, 9]}}
{"token": ["Monoubiquitination", "and", "nuclear", "foci", "formation", "C1414530#ent", "<e1>", "are", "critical", "steps", "of", "the", "C0015625#ent", "<e2>"], "h": {"id": "C1414530", "name": "C1414530#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [12, 13]}}
{"token": ["Overexpression", "of", "LIMK1", "leads", "to", "down-regulation", "of", "C0086661#ent", "<e1>", ",", "whereas", "inhibition", "of", "C0389995#ent", "<e2>", "an", "upstream", "activator", "LIMK1", ",", "stimulates", "C0086661#ent", "<e1>", "expression", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0389995", "name": "C0389995#ent", "pos": [13, 14]}}
{"token": ["CO", "and", "C1420877#ent", "<e1>", "responses", "were", "both", "attenuated", "after", "C1161352#ent", "<e2>", "administration", "(", "68", "%", "and", "718", "%", ",", "respectively", ")", "."], "h": {"id": "C1420877", "name": "C1420877#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [9, 10]}}
{"token": ["The", "identification", "of", "C0597298#ent", "<e1>", "families", "for", "the", "C3831543#ent", "<e2>", "the", "potential", "diversity", "of", "the", "roles", "of", "this", "highly", "conserved", "signaling", "system", "in", "nutrient", "regulation", "and", "utilization", "in", "mammalian", "cells"], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3831543", "name": "C3831543#ent", "pos": [8, 9]}}
{"token": ["Biochemical", "estimations", "tumour", "necrosis", "factor", "alpha", "C1710304#ent", "<e1>", ")", "levels", "and", "C0027203#ent", "<e2>", "parameters", "such", "as", "lipid", "peroxidation", "superoxide", "dismutase", "catalase", "and", "glutathione", "peroxidase", "and", "protein", "estimation"], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["Complementary", "C0011519#ent", "<e1>", "coding", "for", "two", "different", "C1414260#ent", "<e2>", "(", "ET", ")", "receptors", "were", "isolated", "from", "a", "human", "lung", "cDNA", "library"], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414260", "name": "C1414260#ent", "pos": [7, 8]}}
{"token": ["Adenosine", "5'-triphosphate", "C2744579#ent", "<e1>", ")", "synthase", "activity", "checked", "as", "C2744579#ent", "<e1>", "hydrolysis", "(", "C0001473#ent", "<e1>", ")", "at", "37", "degrees", "C", "for", "10", "min", "from", "purified", "mitochondria", "on", "Percoll", "gradient"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [13, 14]}}
{"token": ["A", "tentative", "explanation", "for", "these", "findings", "is", "that", "C2744579#ent", "<e1>", "induces", "lysosomal", "enzyme", "in", "polymorphonuclear", "leukocytes", "reacting", "directly", "with", "an", "C0001473#ent", "<e2>", "which", "needs", "low", "ionic", "strength", "not", "divalent", "cations", "its", "activity", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [20, 21]}}
{"token": ["The", "215", "C0059256#ent", "<e1>", "regions", "with", "similarity", "to", "the", "RNA-binding", "domains", "aspartic", "proteases", "C0178827#ent", "<e2>", "of", "retro-elements", "."], "h": {"id": "C0059256", "name": "C0059256#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0178827", "name": "C0178827#ent", "pos": [13, 14]}}
{"token": ["C2700553#ent", "<e1>", "OS", ")", "is", "a", "rare", "combined", "immunodeficiency", "characterized", "by", "C0011606#ent", "<e2>", ",", "lymphadenopathy", ",", "and", "autoimmune", "manifestations"], "h": {"id": "C2700553", "name": "C2700553#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0011606", "name": "C0011606#ent", "pos": [11, 12]}}
{"token": ["Interestingly", ",", "a", "Hispanic", "patient", "the", "USA", "has", "two", "C0019247#ent", "<e1>", "CIPA", "and", "C0340968#ent", "<e2>", "whose", "genetic", "loci", "both", "mapped", "to", "a", "closely", "linked", "chromosomal", "region"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0340968", "name": "C0340968#ent", "pos": [13, 14]}}
{"token": ["C0004943#ent", "<e1>", "BD", ")", "is", "a", "chronic", ",", "multisystem", "and", "C0042384#ent", "<e2>", "unknown", "etiology", "."], "h": {"id": "C0004943", "name": "C0004943#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [10, 11]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "the", "C3815497#ent", "<e1>", "and", "increased", "cough", "reflex", "sensitivity", "seen", "in", "patients", "with", "C0085786#ent", "<e2>", "be", "due", "to", "airway", "inflammation", "a", "prospective", ",", "cross-sectional", "study"], "h": {"id": "C3815497", "name": "C3815497#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085786", "name": "C0085786#ent", "pos": [17, 18]}}
{"token": ["We", "studied", "the", "synergism", "between", "high-dose", "C0016860#ent", "<e1>", "and", "hydrochlorothiazide", "in", "patients", "with", "severe", "C0018802#ent", "<e2>", "impaired", "renal", "function", "diuretic", "resistance", "a", "daily", "dose", "C0016860#ent", "<e1>", "of", "at", "least", "250", "mg", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}}
{"token": ["A", "previous", "study", "has", "shown", "that", "acute", "administration", "the", "5-HT2", "receptor", "antagonist", "ritanserin", "doubles", "Slow", "Wave", "Sleep", "SWS", ")", "and", "increases", "the", "prolactin", "(", "C3273356#ent", "<e1>", ")", "response", "to", "C0041260#ent", "<e2>", "(", "LTP", ")", "."], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0041260", "name": "C0041260#ent", "pos": [29, 30]}}
{"token": ["The", "effects", "of", "5-hydroxytryptamine", "(", "5-HT", ")", "uptake", "inhibitor", "clomipramine", "on", "the", "prolactin", "(", "C3273356#ent", "<e1>", ")", "and", "growth", "hormone", "GH", ")", "responses", "to", "C0041260#ent", "<e2>", "(", "LTP", ")", "were", "assessed", "in", "six", "normal", "subjects"], "h": {"id": "C3273356", "name": "C3273356#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0041260", "name": "C0041260#ent", "pos": [24, 25]}}
{"token": ["While", "Vira-A", "therapy", "the", "treatment", "for", "diagnosed", "C3540642#ent", "<e1>", "is", "significant", ",", "it", "may", "be", "associated", "with", "difficulties", "in", "C0020488#ent", "<e2>"], "h": {"id": "C3540642", "name": "C3540642#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020488", "name": "C0020488#ent", "pos": [19, 20]}}
{"token": ["Neuroendocrine", "cells", "C1418464#ent", "<e1>", "mRNA", "and", "C3273591#ent", "<e2>", "several", "brain", "regions", "the", "greatest", "proportion", "of", "double-labelled", "cells", "occurring", "in", "the", "arcuate", "nucleus", "Arc", ")", "."], "h": {"id": "C1418464", "name": "C1418464#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273591", "name": "C3273591#ent", "pos": [6, 7]}}
{"token": ["As", "a", "consequence", ",", "the", "rpoN", "mutants", "had", "elevated", "levels", "of", "both", "signal", "molecules", "C3889446#ent", "<e1>", "the", "biosynthetic", "genes", "elastase", ",", "C0106127#ent", "<e2>", ",", "and", "hydrogen", "cyanide"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0106127", "name": "C0106127#ent", "pos": [21, 22]}}
{"token": ["The", "major", "factor", "responsible", "for", "diabetic", "foot", "addition", "to", "C0442874#ent", "<e1>", "seems", "to", "be", "C1096293#ent", "<e2>", "which", "is", "not", "different", "from", "that", "of", "arteriosclerotic", "occlusive", "disease"], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1096293", "name": "C1096293#ent", "pos": [14, 15]}}
{"token": ["Failure", "correlated", "with", "recurrence", "of", "C0039103#ent", "<e1>", ",", "elbow", "instability", ",", "C0154743#ent", "<e2>", "poor", "general", "mobility", "and", "poor", "upper-limb", "function", "."], "h": {"id": "C0039103", "name": "C0039103#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0154743", "name": "C0154743#ent", "pos": [11, 12]}}
{"token": ["These", "data", "strongly", "support", "the", "hypothesis", "that", "the", "sulphur", "of", "biotin", "is", "derived", "from", "the", "(", "C1414588#ent", "<e1>", ")", "centre", "of", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C1414588", "name": "C1414588#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [22, 23]}}
{"token": ["Dopamine", "D2", "receptor", "C1333253#ent", "<e1>", ")", "knockout", "(", "KO", ")", "female", "mice", "develop", "chronic", "hyperprolactinemia", "C0948740#ent", "<e2>"], "h": {"id": "C1333253", "name": "C1333253#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0948740", "name": "C0948740#ent", "pos": [15, 16]}}
{"token": ["Febrile", "illnesses", "common", "among", "children", "in", "Ghana", "and", "are", "often", "diagnosed", "as", "C0024530#ent", "<e1>", ",", "thus", "overlooking", "urinary", "tract", "infection", "C1412376#ent", "<e2>", ")", "as", "a", "possible", "cause", "of", "fever", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412376", "name": "C1412376#ent", "pos": [20, 21]}}
{"token": ["The", "use", "of", "the", "C0013227#ent", "<e1>", "for", "the", "treatment", "of", "C0276226#ent", "<e2>", "one", "of", "the", "gravest", "forms", "of", "encephalitides", ",", "exerts", "a", "beneficial", "effect", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0276226", "name": "C0276226#ent", "pos": [10, 11]}}
{"token": ["Acyclovir", "sodium", "the", "C0013227#ent", "<e1>", "of", "choice", "for", "the", "treatment", "of", "C0276226#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0276226", "name": "C0276226#ent", "pos": [11, 12]}}
{"token": ["Eight", "sera", "from", "five", "West", "African", "persons", "infected", "with", "C0001849#ent", "<e1>", "not", "react", "in", "the", "C0030956#ent", "<e2>", "reflecting", "differences", "in", "properties", "of", "the", "envelope", "components", "."], "h": {"id": "C0001849", "name": "C0001849#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [15, 16]}}
{"token": ["The", "activities", "of", "monoamine", "oxidase", "C0007028#ent", "<e1>", "unaffected", "by", "(+/-)-propranolol", ",", "timolol", "and", "C0071811#ent", "<e2>", "in-vitro", "."], "h": {"id": "C0007028", "name": "C0007028#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0071811", "name": "C0071811#ent", "pos": [13, 14]}}
{"token": ["This", "complex", "includes", "the", "proteins", "RAG1", "RAG2", ",", "HMG-1", "or", "the", "closely", "related", "C1708282#ent", "<e1>", "and", "the", "components", "of", "the", "C1335262#ent", "<e2>"], "h": {"id": "C1708282", "name": "C1708282#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335262", "name": "C1335262#ent", "pos": [20, 21]}}
{"token": ["C1130428#ent", "<e1>", "Photofrin", "II", "is", "a", "C3826984#ent", "<e2>", "which", "distributes", "selectively", "to", "tumor", "tissues", "and", "causes", "tumor", "cell", "death", "combination", "with", "light", "irradiation"], "h": {"id": "C1130428", "name": "C1130428#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3826984", "name": "C3826984#ent", "pos": [6, 7]}}
{"token": ["RNA", "blotting", "the", "presence", "of", "C0019472#ent", "<e1>", "mRNA", "in", "C0023899#ent", "<e2>", "and", "lung", "."], "h": {"id": "C0019472", "name": "C0019472#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [9, 10]}}
{"token": ["Soman", ",", "a", "rapid", "acting", "C0001046#ent", "<e1>", "produces", "a", "C0038220#ent", "<e2>", "leads", "to", "extensive", "neuropathology", "in", "vulnerable", "brain", "regions", "eg", ",", "piriform", "cortex", "hippocampus", ")", "."], "h": {"id": "C0001046", "name": "C0001046#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [9, 10]}}
{"token": ["Both", "were", "homozygous", "for", "a", "high-risk", "immunogenetic", "marker", "C0011860#ent", "<e1>", "i.e.", ",", "non-Asp", "at", "codon", "57", "of", "the", "C1415570#ent", "<e2>"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415570", "name": "C1415570#ent", "pos": [18, 19]}}
{"token": ["This", "article", "examines", "research", "efforts", "over", "the", "last", "20", "years", "describing", "the", "role", "of", "prostaglandins", "in", "C0017563#ent", "<e1>", "the", "effect", "of", "C0080151#ent", "<e2>", "on", "the", "progression", "of", "gingival", "inflammation", "alveolar", "bone", "loss"], "h": {"id": "C0017563", "name": "C0017563#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "treatment", "with", "20", "mg/kg", "C1527219#ent", "<e1>", "in", "the", "C1456377#ent", "<e2>", "diet", "group", "in", "a", "significantly", "lower", "primary", "tumor", "incidence", "(", "P", "<", "0.05", ")", "and", "reduced", "incidence", "of", "metastasis", "."], "h": {"id": "C1527219", "name": "C1527219#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [11, 12]}}
{"token": ["The", "human", "gene", "this", "protein", "has", "been", "termed", "DFF40", "(", "DNA", "fragmentation", "factor", "40-kd", "subunit", ")", "or", "C1413983#ent", "<e1>", "CPAN", ")", ",", "whereas", "the", "mouse", "homologue", "been", "named", "C1504769#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C1413983", "name": "C1413983#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [28, 29]}}
{"token": ["To", "present", "the", "largest", "single", "institutional", "review", "of", "demographics", ",", "associated", "C0242634#ent", "<e1>", "and", "survival", "of", "patients", "receiving", "home", "parenteral", "nutrition", "C3538884#ent", "<e2>", ")", "."], "h": {"id": "C0242634", "name": "C0242634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538884", "name": "C3538884#ent", "pos": [21, 22]}}
{"token": ["Lipoprotein", "composition", "examined", "in", "C0011854#ent", "<e1>", "subjects", "with", "hypercholesterolaemia", "+", "/-", "C0020480#ent", "<e2>", "during", "a", "3-month", "double-blind", "placebo", "controlled", "assessment", "of", "bezafibrate", "therapy", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020480", "name": "C0020480#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "the", "administration", "of", "3.5", "g", "of", "psyllium", "husk", "daily", "for", "90", "days", "was", "investigated", "in", "24", "patients", "of", "C0011854#ent", "<e1>", "NIDDM", ")", "with", "C0020480#ent", "<e2>", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0020480", "name": "C0020480#ent", "pos": [26, 27]}}
{"token": ["A", "series", "of", "familial", "and", "isolated", "European", "probands", "C1704866#ent", "<e1>", "mutations", "were", "analyzed", "for", "germline", "mutations", "C1706016#ent", "<e2>", ",", "a", "member", "of", "the", "transforming", "growth-factor", "beta-receptor", "superfamily", "upstream", "from", "the", "SMAD", "pathway"], "h": {"id": "C1704866", "name": "C1704866#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706016", "name": "C1706016#ent", "pos": [16, 17]}}
{"token": ["C0057239#ent", "<e1>", "synthesized", "through", "a", "series", "of", "reactions", "from", "C0073358#ent", "<e2>", "isolated", "from", "castor", "bean", "oil"], "h": {"id": "C0057239", "name": "C0057239#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0073358", "name": "C0073358#ent", "pos": [9, 10]}}
{"token": ["Mammals", "also", "have", "such", "DNA", "glycosylases", "OGG1", "(", "Ogg1", ")", "is", "the", "functional", "counterpart", "of", "MutM", ",", "and", "C1417505#ent", "<e1>", "(", "Mutyh", ")", "is", "the", "C1879506#ent", "<e2>"], "h": {"id": "C1417505", "name": "C1417505#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1879506", "name": "C1879506#ent", "pos": [25, 26]}}
{"token": ["Inherited", "biallelic", "mutations", "in", "the", "human", "C1417505#ent", "<e1>", "responsible", "for", "the", "recessive", "syndrome", "adenomatous", "colorectal", "polyposis", "C1879506#ent", "<e2>", "associated", "polyposis", ",", "MAP)--which", "significantly", "increases", "the", "risk", "of", "colorectal", "cancer", "CRC", ")", "."], "h": {"id": "C1417505", "name": "C1417505#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1879506", "name": "C1879506#ent", "pos": [16, 17]}}
{"token": ["Inhibitors", "blocking", "primary", "effector", "caspases", "including", "caspase", "3", ",", "the", "FAS", "(", "death", "receptor)-mediated", "C1720986#ent", "<e1>", "including", "caspase", "8)", ",", "and", "stress-induced", "caspases", "including", "C0910167#ent", "<e2>", ",", "were", "tested", "for", "their", "protective", "effects"], "h": {"id": "C1720986", "name": "C1720986#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0910167", "name": "C0910167#ent", "pos": [24, 25]}}
{"token": ["C1720986#ent", "<e1>", "the", "death", "receptor", "pathway", "caspase", "8)", "and", "the", "mitochondrial", "pathway", "C0910167#ent", "<e2>", "as", "well", "as", "effector", "caspase", "3", "activated", "following", "tobacco", "smoke", "."], "h": {"id": "C1720986", "name": "C1720986#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0910167", "name": "C0910167#ent", "pos": [12, 13]}}
{"token": ["Cephalostatin-activated", "caspase-2", "appears", "to", "act", "as", "C1720986#ent", "<e1>", "is", "not", "involved", "in", "the", "activation", "of", "C0910167#ent", "<e2>", "."], "h": {"id": "C1720986", "name": "C1720986#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0910167", "name": "C0910167#ent", "pos": [15, 16]}}
{"token": ["Lowered", "C1456376#ent", "<e1>", "in", "comparison", "to", "controls", "was", "observed", "most", "frequently", "in", "C0024141#ent", "<e2>", "patients", "(", "64.4", "%", ")", "and", "least", "frequently", "in", "DLE", "patients", "(", "32.1", "%", ")", "."], "h": {"id": "C1456376", "name": "C1456376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [12, 13]}}
{"token": ["To", "evaluate", "the", "oral", "health", "status", "patients", "with", "moderate-severe", "C1561643#ent", "<e1>", "CRF", ")", "and", "with", "terminal", "renal", "failure", "C1705002#ent", "<e2>", ")", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705002", "name": "C1705002#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "show", "that", "C1418226#ent", "<e1>", "forms", "a", "complex", "with", "C1334894#ent", "<e2>", ",", "and", "this", "complex", "plays", "a", "critical", "role", "in", "cell", "proliferation", "survival", "."], "h": {"id": "C1418226", "name": "C1418226#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334894", "name": "C1334894#ent", "pos": [11, 12]}}
{"token": ["In", "C0010340#ent", "<e1>", "patients", "with", "suspected", "C1430988#ent", "<e2>", ",", "bedside", "haemodynamic", "evaluation", "and", "balloon-occlusion-angiography", "may", "be", "valuable", ",", "as", "illustrated", "by", "two", "cases", "histories", "."], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [6, 7]}}
{"token": ["C0010340#ent", "<e1>", "patients", "should", "be", "susceptible", "to", "pulmonary", "thromboembolism", "C1430988#ent", "<e2>", ")", "."], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [9, 10]}}
{"token": ["C0014544#ent", "<e1>", ",", "a", "common", "C0027765#ent", "<e2>", "constitutes", "an", "important", "medical", "problem", "as", "in", "the", "developing", "countries", "is", "a", "great", "dearth", "and", "shortage", "of", "health", "personnel", "especially", "trained", "ones", ",", "in", "clinical", "neurosciences"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [5, 6]}}
{"token": ["These", "findings", "support", "a", "possible", "role", "of", "C0020538#ent", "<e1>", "stroke", "as", "an", "inflammatory", "stimulus", "to", "ischemic", "C0014070#ent", "<e2>"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014070", "name": "C0014070#ent", "pos": [16, 17]}}
{"token": ["Transcription", "regulation", "of", "these", "promoters", "involves", "both", "a", "highly", "specific", "C0812382#ent", "<e1>", "C1539372#ent", "<e2>", ")", "and", "a", "low", "specificity", "C0812382#ent", "<e1>", "p6", ")", "functionally", "related", "to", "prokaryotic", "histone-like", "proteins", "."], "h": {"id": "C1539372", "name": "C1539372#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [10, 11]}}
{"token": ["Immunoblot", "analysis", "polyclonal", "antibodies", "C0030956#ent", "<e1>", "representing", "the", "N-", "and", "C-terminal", "hypervariable", "regions", "of", "murine", "C1419208#ent", "<e2>", "recognized", "a", "protein", "of", "approximately", "25", "kd", "in", "hepatocyte", "lysates", ",", "hepatic", "subcellular", "fractions", "and", "tissue", "extracts"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419208", "name": "C1419208#ent", "pos": [15, 16]}}
{"token": ["However", ",", "there", "were", "no", "significant", "differences", "in", "the", "plasma", "C1826646#ent", "<e1>", "response", "to", "C1367472#ent", "<e2>", "between", "lean", "and", "obese", "subjects", "."], "h": {"id": "C1826646", "name": "C1826646#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1367472", "name": "C1367472#ent", "pos": [14, 15]}}
{"token": ["Preliminary", "incubation", "of", "fibroblasts", "with", "8-bromo", "cGMP", "or", "phosphodiesterase", "inhibitors", "including", "3-isobutyl-1-methylxanthine", ",", "Ro", "20", "-", "1724", ",", "and", "C0055728#ent", "<e1>", ",", "however", ",", "prevented", "the", "C1415521#ent", "<e2>", "suppression", "of", "cAMP", "."], "h": {"id": "C0055728", "name": "C0055728#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415521", "name": "C1415521#ent", "pos": [26, 27]}}
{"token": ["The", "C3888274#ent", "<e1>", "generated", "by", "the", "C1415727#ent", "<e2>", "3-OST-3", ")", ",", "and", "it", "provides", "binding", "sites", "viral", "glycoprotein", "D", "gD", ")", "."], "h": {"id": "C3888274", "name": "C3888274#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415727", "name": "C1415727#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "rabbit", "hyperimmune", "sera", "against", "purified", "native", "internal", "components", "measles", "virus", "against", "purified", "virions", "of", "C0025007#ent", "<e1>", "and", "CDV", ",", "untreated", "or", "treated", "with", "C0960371#ent", "<e2>", ",", "were", "prepared", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [26, 27]}}
{"token": ["Here", ",", "we", "show", "that", "FGF21", "activity", "depends", "on", "betaKlotho", ",", "a", "C2329187#ent", "<e1>", "expression", "is", "induced", "during", "differentiation", "from", "C1414069#ent", "<e2>", "to", "adipocytes", "."], "h": {"id": "C2329187", "name": "C2329187#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414069", "name": "C1414069#ent", "pos": [20, 21]}}
{"token": ["We", "used", "this", "C0014432#ent", "<e1>", "characterize", "the", "biological", "effects", "C1835417#ent", "<e2>", "in", "primary", "cells", "two", "growth", "factor-dependent", "BCR-ABL-transfected", "cell", "lines", "."], "h": {"id": "C0014432", "name": "C0014432#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1835417", "name": "C1835417#ent", "pos": [9, 10]}}
{"token": ["Bovine", "splenic", "nerve", "and", "adrenal", "medulla", "used", "as", "C1334043#ent", "<e1>", "sources", "of", "C1413916#ent", "<e2>", "the", "isolation", "of", "enzyme", "specific", "to", "a", "purified", "fraction", "of", "large", "dense", "cored", "noradrenergic", "vesicles", "and", "chromaffin", "granules", "respectively", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413916", "name": "C1413916#ent", "pos": [12, 13]}}
{"token": ["NTPDase1", ",", "NTPDase2", ",", "NTPDase3", ",", "and", "C1740167#ent", "<e1>", "expressions", "were", "not", "affected", "by", "C0031923#ent", "<e2>", "in", "cerebral", "cortex"], "h": {"id": "C1740167", "name": "C1740167#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031923", "name": "C0031923#ent", "pos": [14, 15]}}
{"token": ["The", "C0030940#ent", "<e1>", "Erk2", ",", "protein", "kinase", "B", "PKB", ")", ",", "and", "p70", "ribosomal", "S6", "kinase", "C2827383#ent", "<e2>", "showed", "no", "differences", "in", "activities", "in", "spinal", "cord", "tissue", "ALS", "patients", "and", "controls", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [16, 17]}}
{"token": ["Cell", "proliferation", "the", "co-ordinate", "triggering", "of", "several", "C0030940#ent", "<e1>", "Ser/Thr", "specificity", "such", "as", "p70", "S6", "kinase", "C2827383#ent", "<e2>", ",", "which", "phosphorylates", "the", "ribosomal", "S6", "protein", "thus", "increases", "translation", "of", "mRNAs", "with", "polypyrimidine", "tracts"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [16, 17]}}
{"token": ["The", "same", "TRBD", "is", "found", "directly", "fused", "to", "catalytic", "domains", "plant", "and", "nematode", "C1417035#ent", "<e1>", "as", "well", "as", "human", "C0041497#ent", "<e2>"], "h": {"id": "C1417035", "name": "C1417035#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041497", "name": "C0041497#ent", "pos": [19, 20]}}
{"token": ["The", "three-dimensional", "structures", "two", "animoacyl-tRNA", "synthetases", ",", "the", "methionyl-tRNA", "synthetase", "Escherichia", "coli", "C1417035#ent", "<e1>", ")", "and", "the", "tyrosyl-tRNA", "synthetase", "Bacillus", "stearothermophilus", "C0041497#ent", "<e2>", ")", ",", "show", "a", "remarkable", "similarity", "over", "a", "span", "of", "about", "140", "amino", "acids"], "h": {"id": "C1417035", "name": "C1417035#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041497", "name": "C0041497#ent", "pos": [21, 22]}}
{"token": ["Elevated", "calcitonin", "gene-related", "peptide", "but", "not", "substance", "P", "neurokinin", "A", "is", "only", "associated", "with", "C0010201#ent", "<e1>", "children", "when", "C0341110#ent", "<e2>", "coexists", "."], "h": {"id": "C0010201", "name": "C0010201#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0341110", "name": "C0341110#ent", "pos": [18, 19]}}
{"token": ["The", "c-jun", "proto-oncogene", "a", "transcription", "factor", "is", "activated", "by", "C0026249#ent", "<e1>", "both", "transcriptionally", "and", "by", "phosphorylation", "by", "C1367731#ent", "<e2>", "JNK", ")", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [17, 18]}}
{"token": ["We", "show", "that", "in", "common", "with", "C1367389#ent", "<e1>", "and", "Tec", ",", "C1332433#ent", "<e2>", "reconstituted", "PLCgamma2-dependent", "responses", "including", "calcium", "mobilization", "extracellular", "signal-regulated", "kinase", "ERK", ")", "mitogen-activated", "protein", "kinase", "MAPK", ")", "activation", ",", "and", "apoptosis", "."], "h": {"id": "C1367389", "name": "C1367389#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332433", "name": "C1332433#ent", "pos": [11, 12]}}
{"token": ["The", "Tec", "family", "tyrosine", "kinases", "of", "five", "members", "(", "C1367389#ent", "<e1>", ",", "Rlk", ",", "Tec", ",", "Btk", ",", "and", "C1332433#ent", "<e2>", ")", "that", "are", "expressed", "predominantly", "in", "hematopoietic", "cells"], "h": {"id": "C1367389", "name": "C1367389#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332433", "name": "C1332433#ent", "pos": [19, 20]}}
{"token": ["A", "circular", "midline", "craniotomy", "was", "performed", "to", "C1875400#ent", "<e1>", "the", "superior", "sagittal", "sinus", "C0723181#ent", "<e2>", ")", "for", "electrical", "stimulation", "0.3", "Hz", ",", "150", "V", ",", "250", "micros", "duration", "for", "2", "h", ")", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0723181", "name": "C0723181#ent", "pos": [13, 14]}}
{"token": ["The", "GBS", "detection", "was", "performed", "with", "the", "sequence", "coding", "surface", "immunogenic", "protein", "from", "GBS", "human", "C1875400#ent", "<e1>", "designated", "as", "Sip", "specific", "sequence", "C0723181#ent", "<e2>", ")", ";", "this", "sequence", "was", "selected", "for", "specific", "primer", "design"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0723181", "name": "C0723181#ent", "pos": [22, 23]}}
{"token": ["Synthase", "kinase", "activity", "insensitive", "to", "the", "allosteric", "effector", "(", "C0017755#ent", "<e1>", ")", "or", "substrate", "(", "UDP-glucose", ")", "of", "C1415377#ent", "<e2>", "concentrations", "usually", "found", "under", "physiological", "condition"], "h": {"id": "C0017755", "name": "C0017755#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415377", "name": "C1415377#ent", "pos": [18, 19]}}
{"token": ["C1420068#ent", "<e1>", "is", "a", "member", "of", "the", "basic", "C1420632#ent", "<e2>", "is", "evolutionarily", "related", "to", "the", "Drosophila", "single-minded", "gene", "a", "key", "regulator", "of", "central", "nervous", "system", "development", "."], "h": {"id": "C1420068", "name": "C1420068#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [8, 9]}}
{"token": ["Spinal", "muscular", "atrophy", "type", "I-III", "and", "C0013264#ent", "<e1>", "to", "the", "most", "frequent", "C0751950#ent", "<e2>", "children", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [12, 13]}}
{"token": ["He", "had", "clinical", "findings", "consistent", "with", "Pseudohypoparathyroidism", "(", "C3494506#ent", "<e1>", ")", "with", "hypocalcemia", ",", "C0085681#ent", "<e2>", ",", "and", "increased", "parathyroid", "hormone", "PTH", ")", "concentration", "."], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0085681", "name": "C0085681#ent", "pos": [14, 15]}}
{"token": ["Likewise", ",", "expression", "of", "C0017337#ent", "<e1>", "participating", "in", "duodenal", "Fe", "uptake", "(", "C1427130#ent", "<e2>", ",", "DMT1", ")", "and", "transfer", "(", "ferroportin", ")", "were", "increased", "in", "TfR2", "mutant", "mice", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1427130", "name": "C1427130#ent", "pos": [12, 13]}}
{"token": ["Binding", "analysis", "that", "the", "Ena/Vasp", "homology", "1", "domain", "of", "C2348366#ent", "<e1>", "and", "the", "polyproline", "structure", "of", "C1705546#ent", "<e2>", "are", "necessary", "for", "the", "interaction", "."], "h": {"id": "C2348366", "name": "C2348366#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705546", "name": "C1705546#ent", "pos": [16, 17]}}
{"token": ["On", "day", "15", ",", "C0039855#ent", "<e1>", "became", "insufficient", "to", "manage", "the", "C0036572#ent", "<e2>", "frequent", "intravenous", "administration", "other", "sedative", "and", "muscle", "relaxants"], "h": {"id": "C0039855", "name": "C0039855#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [11, 12]}}
{"token": ["C3827899#ent", "<e1>", "TS", "PST", "or", "C1420514#ent", "<e2>", ")", "was", "initially", "thought", "to", "catalyze", "the", "reaction", ",", "and", "the", "enzyme", "was", "designated", "minoxidil", "sulfotransferase", "MNX-ST", ")", "."], "h": {"id": "C3827899", "name": "C3827899#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420514", "name": "C1420514#ent", "pos": [5, 6]}}
{"token": ["To", "assess", "the", "activating", "capacities", "of", "individual", "C3827899#ent", "<e1>", "five", "different", "forms", ",", "human", "ST1A2", "and", "C1420514#ent", "<e2>", "and", "rat", "ST1A1", ",", "ST1B1", "and", "ST1C1", ",", "were", "expressed", "in", "heterologous", "cells", "."], "h": {"id": "C3827899", "name": "C3827899#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420514", "name": "C1420514#ent", "pos": [16, 17]}}
{"token": ["The", "C4284136#ent", "<e1>", "an", "activating", "C1334043#ent", "<e2>", "of", "the", "inhibitory", "killer-cell", "immunoglobulin-like", "receptors", "KIR", ")", "that", "recognize", "HLA-C", "molecules", ",", "enabling", "NK", "cells", "survey", "the", "normal", "function", "endogenous", "antigen", "presentation", "."], "h": {"id": "C4284136", "name": "C4284136#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}}
{"token": ["We", "have", "determined", "the", "crystal", "structure", "the", "carbohydrate", "recognition", "domain", "(", "CRD", ")", "of", "C4284136#ent", "<e1>", ",", "the", "rat", "C1334043#ent", "<e2>", "of", "human", "ERGIC-53", ",", "to", "1.46", "A", "resolution", "."], "h": {"id": "C4284136", "name": "C4284136#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "show", "that", "C1420831#ent", "<e1>", "prolongs", "the", "C0720099#ent", "<e2>", "of", "vegetative", "growth", "prolonging", "the", "overall", "C0720099#ent", "<e2>", "of", "shoot", "growth"], "h": {"id": "C1420831", "name": "C1420831#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [9, 10]}}
{"token": ["This", "variation", "in", "presentation", "can", "make", "it", "difficult", "to", "diagnose", "C1535939#ent", "<e1>", "or", "myocardial", "infarction", "exacerbations", "of", "C0008679#ent", "<e2>", "such", "as", "depression", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [17, 18]}}
{"token": ["The", "coagulant", "protein", "as", "an", "C0027203#ent", "<e1>", "in", "activating", "C0015518#ent", "<e2>", "the", "presence", "of", "Ca2", "+", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015518", "name": "C0015518#ent", "pos": [9, 10]}}
{"token": ["In", "this", "study", ",", "we", "administered", "an", "anti-CD45RB", "mAb", "C1335285#ent", "<e1>", ")", "in", "a", "murine", "model", "of", "allergic", "asthma", "found", "that", "C3891562#ent", "<e2>", "decreases", "allergic", "responses"], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3891562", "name": "C3891562#ent", "pos": [21, 22]}}
{"token": ["These", "findings", "suggest", "that", "some", "C0234533#ent", "<e1>", "patients", "have", "impaired", "brain", "C0242898#ent", "<e2>", "neurons", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [11, 12]}}
{"token": ["Recent", "examples", "of", "such", "progress", "include", "new", "data", "on", "seizure-related", "brain", "water", "changes", ",", "brain", "metabolic", "abnormalities", "in", "C0234533#ent", "<e1>", "patients", ",", "and", "pharmacologic", "manipulation", "C0242898#ent", "<e2>"], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [25, 26]}}
{"token": ["Incubation", "of", "C1707080#ent", "<e1>", "with", "recombinant", "C1176140#ent", "<e2>", "produced", "most", "of", "the", "metabolites", "detected", "from", "incubation", "with", "human", "liver", "microsomes", ",", "which", "was", "used", "for", "large-scale", "preparation", "of", "the", "metabolites", "."], "h": {"id": "C1707080", "name": "C1707080#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [6, 7]}}
{"token": ["Two", "cases", "of", "C0017547#ent", "<e1>", "left", "middle", "cerebral", "artery", "aneurysm", "presenting", "with", "rapidly", "progressing", "C0018989#ent", "<e2>", "and", "aphasia", "are", "presented", "."], "h": {"id": "C0017547", "name": "C0017547#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "suggest", "that", "using", "a", "pooled", "variance", "contralateral", "hemisphere", "normalisation", ",", "statistical", "parametric", "mapping", "be", "used", "to", "objectively", "identify", "regions", "of", "increased", "C3272664#ent", "<e1>", "uptake", "following", "C0038454#ent", "<e2>", "individual", "subjects"], "h": {"id": "C3272664", "name": "C3272664#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [27, 28]}}
{"token": ["The", "non-nucleoside", "reverse", "transcriptase", "inhibitor", "C0288165#ent", "<e1>", "potently", "inhibits", "C3714798#ent", "<e2>", ",", "whereas", "nevirapine", "and", "efavirenz", "are", "inducers", "of", "C3714798#ent", "<e2>", "."], "h": {"id": "C0288165", "name": "C0288165#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [9, 10]}}
{"token": ["We", "will", "then", "review", "in", "vitro", "in", "vivo", "data", "supporting", "a", "critical", "role", "of", "C1860658#ent", "<e1>", "in", "TH-induced", "larval", "epithelial", "cell", "death", "C3889469#ent", "<e2>", "remodeling", "."], "h": {"id": "C1860658", "name": "C1860658#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3889469", "name": "C3889469#ent", "pos": [22, 23]}}
{"token": ["The", "anterior", "pituitary-specific", "transcription", "factor", "C3539832#ent", "<e1>", ",", "activates", "prolactin", ",", "growth", "hormone", "TSH", "beta", "C1415063#ent", "<e2>", "autoregulates", "the", "pit-1", "gene", "."], "h": {"id": "C3539832", "name": "C3539832#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415063", "name": "C1415063#ent", "pos": [15, 16]}}
{"token": ["The", "content", "of", "phosphatidylcholine", "(", "PC", ")", "and", "C0000039#ent", "<e1>", "(", "DPPC", ")", "after", "treatment", "with", "C3273356#ent", "<e2>", "was", "demonstrated", "to", "be", "significantly", "higher", "than", "the", "control", "."], "h": {"id": "C0000039", "name": "C0000039#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273356", "name": "C3273356#ent", "pos": [16, 17]}}
{"token": ["The", "neuroprotective", "action", "a", "C0039659#ent", "<e1>", "ceruletide", ",", "was", "evaluated", "in", "models", "of", "C0007785#ent", "<e2>", "Mongolian", "gerbils"], "h": {"id": "C0039659", "name": "C0039659#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [13, 14]}}
{"token": ["Human", "neutrophils", "treated", "with", "pertussis", "toxin", "decreased", "functional", "responses", "to", "several", "C0035064#ent", "<e1>", "including", "zymosan-treated", "serum", ",", "heat-aggregated", "immunoglobulin", ",", "C0914069#ent", "<e2>", "and", "fMet-Leu-Phe", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0914069", "name": "C0914069#ent", "pos": [20, 21]}}
{"token": ["We", "have", "used", "complementarity-determining", "region", "3", "CDR3", ")", "size", "distribution", "analysis", "assess", "C0524889#ent", "<e1>", "TCR", ")", "Vbeta", "repertoire", "in", "13", "patients", "with", "C0043194#ent", "<e2>", "."], "h": {"id": "C0524889", "name": "C0524889#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0043194", "name": "C0043194#ent", "pos": [22, 23]}}
{"token": ["These", "results", "show", "that", "Nrf2", "mediates", "induction", "of", "Mrp3", "and", "Mrp4", "after", "C0000970#ent", "<e1>", "but", "does", "not", "affect", "Mrp1", "or", "C1416664#ent", "<e2>", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416664", "name": "C1416664#ent", "pos": [20, 21]}}
{"token": ["Most", "of", "the", "total", "collagenase", "in", "whole", "saliva", "healthy", "subjects", "of", "C0162745#ent", "<e1>", ",", "while", "mainly", "active", "collagenase", "present", "in", "whole", "saliva", "patients", "with", "C0017563#ent", "<e2>"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [24, 25]}}
{"token": ["The", "enzyme(s", ")", "may", "augment", "the", "action", "of", "C0162745#ent", "<e1>", "and", "other", "neutral", "proteases", "connective", "tissue", "associated", "with", "etiopathogenesis", "of", "C0017563#ent", "<e2>"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [20, 21]}}
{"token": ["The", "first", "activated", "C1334693#ent", "<e1>", "the", "PTX-sensitive", "Gbeta(4", ")", "subunit", "coupled", "to", "C0250416#ent", "<e2>", "which", "triggered", "a", "rapid", "(", "5", "s", ")", "increase", "in", "intracellular", "calcium", "and", "diacylglycerol", "formation"], "h": {"id": "C1334693", "name": "C1334693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0250416", "name": "C0250416#ent", "pos": [12, 13]}}
{"token": ["Mutations", "in", "the", "gene", "encoding", "the", "gamma(2", ")", "subunit", "of", "the", "AMP-activated", "protein", "kinase", "C1418898#ent", "<e1>", ")", "have", "recently", "been", "shown", "to", "cause", "cardiac", "hypertrophy", "C0559106#ent", "<e2>", "Wolff-Parkinson-White", "syndrome", "."], "h": {"id": "C1418898", "name": "C1418898#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0559106", "name": "C0559106#ent", "pos": [25, 26]}}
{"token": ["In", "contrast", ",", "a", "fusion", "protein", "of", "the", "C1416832#ent", "<e1>", "DBD", "and", "amino", "acids", "1", "118", "of", "C1413323#ent", "<e2>", "provides", "a", "significant", "glucocorticoid", "response"], "h": {"id": "C1416832", "name": "C1416832#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413323", "name": "C1413323#ent", "pos": [17, 18]}}
{"token": ["The", "C0024228#ent", "<e1>", "17", "%", "of", "the", "escaped", "C1412332#ent", "<e2>", ",", "from", "the", "liver", "about", "12", "%", "from", "the", "intestines", "and", "almost", "all", "from", "the", "kidneys", "."], "h": {"id": "C0024228", "name": "C0024228#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [8, 9]}}
{"token": ["Efficient", "protoplasting", "required", "reducing", "C0035064#ent", "<e1>", "and", "proteases", "together", "with", "beta-glucanases", "(", "C0078859#ent", "<e2>", ")", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0078859", "name": "C0078859#ent", "pos": [12, 13]}}
{"token": ["The", "analysis", "was", "limited", "to", "alleles", "known", "to", "be", "associated", "with", "increased", "or", "decreased", "risk", "of", "early-onset", "C0157917#ent", "<e1>", "of", "chronic", "iridocyclitis", "this", "form", "of", "C3714757#ent", "<e2>"], "h": {"id": "C0157917", "name": "C0157917#ent", "pos": [17, 18]}, "relation": "has_nichd_parent", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [25, 26]}}
{"token": ["We", "report", "the", "case", "of", "a", "41-year-old", "man", "with", "iatrogenic", "Creutzfeldt-Jakob", "disease", "C0022336#ent", "<e1>", ")", "acquired", "after", "the", "use", "of", "growth", "hormone", "C3539616#ent", "<e2>", ")", "obtained", "from", "a", "number", "of", "pituitary", "glands", "from", "autopsy", "material"], "h": {"id": "C0022336", "name": "C0022336#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "two", "other", "genes", "were", "expressed", "-related", "C1420400#ent", "<e1>", "a", "dorsal", "mesodermal", "marker", ")", "and", "C1417546#ent", "<e2>", "MLC2-heart", "marker", ")", "."], "h": {"id": "C1420400", "name": "C1420400#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417546", "name": "C1417546#ent", "pos": [17, 18]}}
{"token": ["2", ")", "The", "frequency", "of", "coronary", "atherosclerosis", "associated", "with", "C1260873#ent", "<e1>", "much", "higher", "in", "C0003507#ent", "<e2>", "in", "aortic", "regurgitation", "respectively", "35", "%", "versus", "15", "%", "."], "h": {"id": "C1260873", "name": "C1260873#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [14, 15]}}
{"token": ["C1260873#ent", "<e1>", "particularly", "critical", "C0003507#ent", "<e2>", "if", "unrecognized", ",", "can", "precipitate", "rapid", "patient", "deterioration", "if", "inappropriately", "treated", "with", "nitrate", "therapy", "presumed", "ischemic", "disease"], "h": {"id": "C1260873", "name": "C1260873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [4, 5]}}
{"token": ["Activation", "of", "C1363984#ent", "<e1>", "increased", "the", "expression", "of", "vascular", "endothelial", "growth", "factor", "p21(WAF1/CIP1", ")", ",", "and", "C1743497#ent", "<e2>", "MCF7", "breast", "cancer", "cells", "and", "increased", "the", "expression", "of", "CCl2/MCP-1", "and", "IL-1beta", "in", "THP-1", "macrophages", "."], "h": {"id": "C1363984", "name": "C1363984#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [16, 17]}}
{"token": ["Our", "studies", "further", "establish", "vl", "as", "a", "multigenic", "mouse", "model", "NTDs", "and", "identify", "additional", "C0597336#ent", "<e1>", "that", "interact", "with", "C1428198#ent", "<e2>", "to", "regulate", "neurulation", "."], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1428198", "name": "C1428198#ent", "pos": [19, 20]}}
{"token": ["This", "study", "employed", "various", "monitoring", "methods", "assess", "the", "impact", "of", "repeated", "rounds", "of", "mass", "drug", "administration", "MDA", ")", "on", "C0392663#ent", "<e1>", "Papua", "New", "Guinea", "which", "has", "the", "largest", "C0016085#ent", "<e2>", "problem", "in", "the", "Pacific", "region", "."], "h": {"id": "C0392663", "name": "C0392663#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0016085", "name": "C0016085#ent", "pos": [28, 29]}}
{"token": ["Footprinting", "experiments", "demonstrated", "that", "C3641847#ent", "<e1>", "binds", "to", "C1823635#ent", "<e2>", "in", "a", "sequence-specific", "manner", "bends", "or", "untwists", "the", "DNA", "at", "two", "symmetry-related", "sites", "in", "region", "II"], "h": {"id": "C3641847", "name": "C3641847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1823635", "name": "C1823635#ent", "pos": [8, 9]}}
{"token": ["Chromatin", "immunoprecipitation", "analysis", "cells", "treated", "with", "trichostatin", "A", "a", "significant", "increase", "in", "the", "acetylation", "of", "histone", "H4", "but", "not", "C3829685#ent", "<e1>", "across", "approximately", "650", "bp", "of", "the", "C0919490#ent", "<e2>", "promoter", "region"], "h": {"id": "C3829685", "name": "C3829685#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [27, 28]}}
{"token": ["It", "is", "suggested", "that", "C1564434#ent", "<e1>", "is", "contraindicated", "in", "patients", "with", "severe", "C0155874#ent", "<e2>"], "h": {"id": "C1564434", "name": "C1564434#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155874", "name": "C0155874#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "exogenous", "induction", "of", "TAp63gamma", "(", "p51A", ")", ",", "a", "C1334043#ent", "<e1>", "of", "p53", ",", "canceled", "the", "effect", "of", "C0042679#ent", "<e2>", "on", "mTUBB2", "expression", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [21, 22]}}
{"token": ["C1334043#ent", "<e1>", "within", "RDase", "subclusters", "containing", "PceA", ",", "TceA", ",", "and", "C0042679#ent", "<e2>", "were", "among", "the", "most", "frequently", "identified", "proteins", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [11, 12]}}
{"token": ["Earlier", "work", "showed", "that", "Escherichia", "coli", "at", "least", "two", "C3540772#ent", "<e1>", "which", "reduce", "nitrofurazone", "and", "other", "C3540041#ent", "<e2>"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540041", "name": "C3540041#ent", "pos": [16, 17]}}
{"token": ["This", "suggests", "the", "possible", "implication", "of", "C0042373#ent", "<e1>", "the", "aetiology", "of", "C4023106#ent", "<e2>", "men", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4023106", "name": "C4023106#ent", "pos": [11, 12]}}
{"token": ["C0070310#ent", "<e1>", "was", "found", "to", "have", "similar", "activity", "to", "C0006971#ent", "<e2>", ",", "cyclophosphamide", "or", "mitomycin", "C", "P388", "leukemia"], "h": {"id": "C0070310", "name": "C0070310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006971", "name": "C0006971#ent", "pos": [9, 10]}}
{"token": ["Both", "NaCh6", "mRNA", "and", "protein", "were", "detected", "in", "the", "spinal", "cord", "C3273601#ent", "<e1>", "and", "were", "expressed", "clearly", "at", "C1424742#ent", "<e2>", "in", "motor", "neurons"], "h": {"id": "C3273601", "name": "C3273601#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1424742", "name": "C1424742#ent", "pos": [18, 19]}}
{"token": ["The", "developmental", "profile", "alpha-actinin-2", "immunoreactivity", "the", "presence", "of", "alpha-actinin-2", "in", "the", "hippocampus", "at", "C3273601#ent", "<e1>", ",", "labeling", "of", "interneurons", "by", "C1424742#ent", "<e2>", "and", "the", "adult", "staining", "pattern", "seen", "by", "P21", "."], "h": {"id": "C3273601", "name": "C3273601#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1424742", "name": "C1424742#ent", "pos": [20, 21]}}
{"token": ["Phi", "values", "for", "C0878279#ent", "<e1>", "(", "on", "the", "E45A", "background", ",", "L210", ",", "and", "C0591430#ent", "<e2>", "were", "0.74", ",", "0.35", ",", "and", "0.80", ",", "respectively", "."], "h": {"id": "C0878279", "name": "C0878279#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0591430", "name": "C0591430#ent", "pos": [14, 15]}}
{"token": ["The", "S6", "kinases", "purified", "from", "liver", "of", "cycloheximide-treated", "rat", "and", "H4", "hepatoma", "enzyme", "are", "each", "completely", "deactivated", "by", "incubation", "with", "C1704708#ent", "<e1>", "both", "autophosphorylating", "and", "C2984184#ent", "<e2>", "activities", "."], "h": {"id": "C1704708", "name": "C1704708#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2984184", "name": "C2984184#ent", "pos": [25, 26]}}
{"token": ["Mitogens", "such", "as", "the", "L4", "isolectin", "C0030779#ent", "<e1>", "might", "be", "applied", "to", "treat", "C0002874#ent", "<e2>", "three", "different", "ways", "."], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [13, 14]}}
{"token": ["In", "vitro", "sensitization", "experiments", "using", "PBMC", "and", "the", "15-mer", "C0030956#ent", "<e1>", "yielded", "peptide-specific", "responses", "against", "both", "WT12e", "and", "C1704667#ent", "<e2>", "from", "six", "of", "seven", "healthy", "donors", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704667", "name": "C1704667#ent", "pos": [18, 19]}}
{"token": ["Using", "chloral", "hydrate-anesthetized", "adult", "Sprague-Dawley", "rats", "we", "compared", "the", "distribution", "of", "C0812302#ent", "<e1>", "immunoreactivity", "after", "intracerebroventricular", "administration", "of", "C1421143#ent", "<e2>", "the", "results", "after", "intracerebroventricular", "injection", "of", "vehicle", "alone", "."], "h": {"id": "C0812302", "name": "C0812302#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [18, 19]}}
{"token": ["On", "the", "other", "hand", ",", "in", "patients", "with", "C1332629#ent", "<e1>", "5", "showed", "an", "elevated", "level", "of", "C1418938#ent", "<e2>", "alone", "."], "h": {"id": "C1332629", "name": "C1332629#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "report", "that", "overproduction", "of", "either", "C1431394#ent", "<e1>", "or", "kinase-inactive", "forms", "of", "C1417584#ent", "<e2>", "blocked", "the", "nuclear-cytoplasmic", "shuttling", "cyclin", "B1", "caused", "cells", "to", "delay", "in", "the", "G2", "phase", "the", "cell", "cycle"], "h": {"id": "C1431394", "name": "C1431394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417584", "name": "C1417584#ent", "pos": [13, 14]}}
{"token": ["Microarray", "analysis", "that", "in", "the", "stimulated", "C0030196#ent", "<e1>", "of", "rats", "C0342895#ent", "<e2>", "a", "low-salt", "diet", "genes", "related", "to", "angiogenesis", "were", "upregulated", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [10, 11]}}
{"token": ["BMPs", "signal", "through", "a", "combination", "of", "three", "type", "II", "receptors", "BMPRII", ",", "C1704933#ent", "<e1>", ",", "and", "ActRIIB", "and", "four", "type", "I", "receptors", "C1366565#ent", "<e2>", ",", "2", ",", "3", ",", "and", "6", "."], "h": {"id": "C1704933", "name": "C1704933#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366565", "name": "C1366565#ent", "pos": [22, 23]}}
{"token": ["2", "Contractile", "responses", "KCl", "and", "C3887648#ent", "<e1>", ",", "but", "not", "those", "of", "S1P", "or", "C1425074#ent", "<e2>", ",", "were", "significantly", "related", "to", "vessel", "diameter", "in", "both", "species", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425074", "name": "C1425074#ent", "pos": [14, 15]}}
{"token": ["To", "date", "C1413172#ent", "<e1>", ",", "encoding", "the", "C1413172#ent", "<e1>", "and", "EMS1", ",", "encoding", "the", "filamentous", "actin", "binding", "protein", "c-Src", "substrate", "cortactin", ",", "are", "the", "favored", "candidates", "responsible", "for", "the", "emergence", "of", "two", "of", "the", "four", "amplification", "cores"], "h": {"id": "C1413172", "name": "C1413172#ent", "pos": [2, 3]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1413172", "name": "C1413172#ent", "pos": [2, 3]}}
{"token": ["In", "addition", ",", "C0339510#ent", "<e1>", "values", "on", "the", "amputated", "limbs", "residual", "C0239377#ent", "<e2>", "significantly", "less", "than", "in", "those", "without", "residual", "C0239377#ent", "<e2>"], "h": {"id": "C0339510", "name": "C0339510#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [11, 12]}}
{"token": ["At", "42", "mg/kg", "bwt", ",", "C0114346#ent", "<e1>", "effected", "a", "small", "increase", "(", "2.8-fold", ")", "in", "C0059735#ent", "<e2>", "and", "at", "both", "dose", "levels", "it", "reduced", "CYP3A1/2", "activity", "by", "approximately", "40", "%", "."], "h": {"id": "C0114346", "name": "C0114346#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [15, 16]}}
{"token": ["The", "C3494348#ent", "<e1>", "suppression", "of", "C0812281#ent", "<e2>", "generation", "caused", "by", "BAX(oligo", ")", "but", "not", "by", "alamethicin", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [5, 6]}}
{"token": ["Cyclosporin", "A", "plus", "trifluoperazine", ",", "C3494348#ent", "<e1>", "of", "the", "mitochondrial", "permeability", "transition", "inhibited", "mitochondrial", "inner", "membrane", "permeabilization", "depolarization", "without", "affecting", "mitochondrial", "C0812281#ent", "<e2>", "generation", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "comparative", "immunofluorescence", "analyses", "retinae", "from", "mice", "deficient", "for", "Cx31", ",", "C1415076#ent", "<e1>", ",", "or", "Cx40", "with", "retinae", "of", "C2987364#ent", "<e2>", "mice", "revealed", "no", "specific", "immunostaining", "."], "h": {"id": "C1415076", "name": "C1415076#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}}
{"token": ["Northern", "and", "Western", "blot", "analyses", "C1415076#ent", "<e1>", "mRNA", "and", "protein", "in", "cells", "with", "the", "C2987364#ent", "<e2>", "well", "as", "with", "the", "mutant", "Cx32", "genes", "."], "h": {"id": "C1415076", "name": "C1415076#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [14, 15]}}
{"token": ["This", "study", "sought", "to", "determine", "whether", "C0380964#ent", "<e1>", "a", "role", "in", "the", "pathogenesis", "of", "fatal", "C0524702#ent", "<e2>"], "h": {"id": "C0380964", "name": "C0380964#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524702", "name": "C0524702#ent", "pos": [15, 16]}}
{"token": ["They", "also", "suggest", "that", "C1417951#ent", "<e1>", "is", "a", "candidate", "C0017337#ent", "<e2>", "for", "diabetes", "mellitus", "humans", "."], "h": {"id": "C1417951", "name": "C1417951#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["We", "report", "here", "a", "case", "of", "a", "63-year-old", "cachectic", "female", "who", "had", "classic", "C0017677#ent", "<e1>", "lesions", "of", "C0001202#ent", "<e2>", "of", "Bazex", "with", "underlying", "bronchogenic", "carcinoma", "the", "right", "lung"], "h": {"id": "C0017677", "name": "C0017677#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001202", "name": "C0001202#ent", "pos": [17, 18]}}
{"token": ["For", "evaluation", "of", "the", "results", ",", "termination", "of", "the", "reactions", "with", "a", "specific", "C3536890#ent", "<e1>", "especially", "important", "in", "the", "case", "of", "the", "C0163582#ent", "<e2>"], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0163582", "name": "C0163582#ent", "pos": [22, 23]}}
{"token": ["Therefore", ",", "C0002586#ent", "<e1>", ",", "phenazone", ",", "and", "C0072245#ent", "<e2>", "were", "tested", "for", "periods", "up", "to", "16", "weeks", "."], "h": {"id": "C0002586", "name": "C0002586#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072245", "name": "C0072245#ent", "pos": [8, 9]}}
{"token": ["A", "45-year-old", "woman", "with", "steroid-dependent", "Crohn's", "colitis", "successfully", "managed", "with", "maintenance", "infliximab", "infusions", "and", "C0025677#ent", "<e1>", ",", "developed", "a", "C0919715#ent", "<e2>", "months", "after", "her", "initial", "infusion", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0919715", "name": "C0919715#ent", "pos": [19, 20]}}
{"token": ["The", "secretory", "responses", "hepatic", "bile", "C0700138#ent", "<e1>", "intraduodenal", "infusion", "of", "propionate", "(", "C1418225#ent", "<e2>", ")", ",", "3Cl-PA", ",", "2Cl-PA", ",", "3Br-PA", "and", "2Br-PA", "solutions", "were", "examined", "in", "anesthetized", "piglets", "."], "h": {"id": "C0700138", "name": "C0700138#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418225", "name": "C1418225#ent", "pos": [12, 13]}}
{"token": ["The", "Ets", "binding", "region", "of", "the", "ATPsyn", "beta", "promoter", "increased", "basal", "expression", "and", "conferred", "C0812201#ent", "<e1>", "and", "Ets-2-dependent", "trans-activation", "to", "the", "C1333929#ent", "<e2>", "promoter", "."], "h": {"id": "C0812201", "name": "C0812201#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333929", "name": "C1333929#ent", "pos": [21, 22]}}
{"token": ["C0011777#ent", "<e1>", "(", "DEX", ")", "has", "been", "shown", "to", "significantly", "reduce", "C1311070#ent", "<e2>", "hepatotoxicity", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1311070", "name": "C1311070#ent", "pos": [11, 12]}}
{"token": ["In", "this", "paper", "we", "show", "that", "Tra", "and", "C1705722#ent", "<e1>", "act", "by", "recruiting", "C1419989#ent", "<e2>", "a", "regulatory", "element", "downstream", "of", "a", "female-specific", "3", "'", "splice", "site"], "h": {"id": "C1705722", "name": "C1705722#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419989", "name": "C1419989#ent", "pos": [13, 14]}}
{"token": ["Plasma", "osteocalcin", ",", "C1412791#ent", "<e1>", "mRNA", "levels", ",", "and", "adrenomedullary", "tyrosine", "hydroxylase", "TH", ")", ",", "C0013032#ent", "<e2>", "DBH", ")", ",", "and", "phenylethanolamine", "N-methyl", "transferase", "PNMT", ")", "mRNA", "levels", "were", "quantified", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013032", "name": "C0013032#ent", "pos": [15, 16]}}
{"token": ["C3273406#ent", "<e1>", "promotes", "the", "association", "of", "scaffolding", "proteins", "such", "as", "paxillin", ",", "C1420760#ent", "<e2>", ",", "and", "p130Cas", ",", "leading", "to", "focal", "adhesion", "extracellular", "matrix", "formation", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420760", "name": "C1420760#ent", "pos": [12, 13]}}
{"token": ["Antisense", "oligodeoxynucleotides", "at", "5", "micromol/L", "to", "PKC-alpha", ",", "but", "not", "those", "to", "the", "C3710929#ent", "<e1>", "isoform", ",", "suppressed", "the", "lyso-PC-mediated", "increases", "in", "C3888088#ent", "<e2>", "migration", "and", "oxidative", "stress"], "h": {"id": "C3710929", "name": "C3710929#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [22, 23]}}
{"token": ["Progressive", "carboxyl-terminal", "truncations", "of", "the", "C0022159#ent", "<e1>", "transcribed", "and", "translated", "to", "yield", "C1305923#ent", "<e2>", "with", "the", "same", "amino", "terminus", "but", "lacking", "varying", "amounts", "of", "the", "carboxyl", "terminus"], "h": {"id": "C0022159", "name": "C0022159#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}}
{"token": ["In", "support", ",", "the", "PACAP", "gene", "was", "synergistically", "enhanced", "by", "C0001477#ent", "<e1>", "cAMP", "signals", "through", "the", "C1511573#ent", "<e2>", ",", "accompanying", "a", "prolonged", "activation", "of", "extracellular", "signal-related", "protein", "kinase", "1/2", "CRE-binding", "protein"], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "support", "that", "not", "only", "CREB", "but", "also", "USF1/USF2", "contributes", "to", "C0001477#ent", "<e1>", "activation", "of", "BDNF-PI", "through", "the", "recognition", "of", "an", "overlapping", "C1511573#ent", "<e2>", "and", "USF-binding", "element", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [23, 24]}}
{"token": ["We", "conclude", "that", "C1142644#ent", "<e1>", "is", "responsible", "for", "C0015846#ent", "<e2>", "and", "sufentanil", "N-dealkylation", "in", "vitro"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [3, 4]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0015846", "name": "C0015846#ent", "pos": [8, 9]}}
{"token": ["The", "possible", "causes", "for", "C0024214#ent", "<e1>", "of", "the", "C0014541#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C0024214", "name": "C0024214#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014541", "name": "C0014541#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "report", "that", "transfection", "of", "G-kinase", "into", "G-kinase-deficient", "cells", "causes", "activation", "of", "the", "human", "C1706383#ent", "<e1>", "promoter", "in", "a", "strictly", "C1336838#ent", "<e2>", "manner", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1336838", "name": "C1336838#ent", "pos": [21, 22]}}
{"token": ["Treatment", "of", "C0917798#ent", "<e1>", "the", "rat", "with", "intraperitoneal", "administration", "progesterone", "dissolved", "in", "C0012403#ent", "<e2>", "DMSO", ")", "has", "demonstrated", "therapeutic", "efficacy"], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012403", "name": "C0012403#ent", "pos": [12, 13]}}
{"token": ["Starting", "with", "a", "brief", "review", "of", "severe", "acute", "respiratory", "syndrome", "highlight", "the", "kinds", "of", "problems", "we", "face", "in", "learning", "about", "this", "C0042769#ent", "<e1>", "I", "then", "turn", "to", "C0021400#ent", "<e2>", "focusing", "on", "three", "topics", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [21, 22]}, "relation": "nichd_parent_of", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [27, 28]}}
{"token": ["In", "addition", ",", "we", "determined", "if", "nitric", "oxide", "NO", ")", "contributes", "to", "cerebrovascular", "tone", "isoflurane", "anesthesia", "determining", "the", "C1428360#ent", "<e1>", "(", "microsphere", ")", "response", "to", "inhibition", "of", "C1538973#ent", "<e2>", "N", "omega-nitro-L-arginine", "methyl", "ester", "L-NAME", ")", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1538973", "name": "C1538973#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", ",", "the", "presence", "of", "genes", "encoding", "C1418818#ent", "<e1>", "and", "related", "C0026741#ent", "<e2>", "the", "genomes", "of", "five", "Plasmodium", "species", "of", "Toxoplasma", "gondii", "that", "these", "parasites", "contain", "only", "one", "single", "C1418818#ent", "<e1>", "."], "h": {"id": "C1418818", "name": "C1418818#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [12, 13]}}
{"token": ["Chromatin", "immunoprecipitation", "results", "demonstrate", "in", "vivo", "association", "of", "C1333572#ent", "<e1>", "with", "the", "cyclin", "D2", "promoter", "in", "untreated", "C4283742#ent", "<e2>", "and", "release", "of", "C1333572#ent", "<e1>", "from", "the", "cyclin", "D2", "promoter", "upon", "addition", "of", "FSH", "plus", "activin", "."], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283742", "name": "C4283742#ent", "pos": [17, 18]}}
{"token": ["Surprisingly", ",", "we", "find", "that", "C1335888#ent", "<e1>", "and", "SWP61", "are", "encoded", "by", "the", "ARP9", "and", "ARP7", "C1417679#ent", "<e2>", ",", "respectively", ",", "which", "encode", "members", "of", "the", "actin-related", "protein", "ARP", ")", "family", "."], "h": {"id": "C1335888", "name": "C1335888#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["In", "comparison", "to", "granulocytic", "HL-60", "cells", "blood", "neutrophil", "nuclear", "envelopes", "low-to-negligible", "amounts", "of", "LBR", ",", "lamins", "A/C", "C1842747#ent", "<e1>", "and", "B2", ",", "LAP2beta", "and", "C0295734#ent", "<e2>", "."], "h": {"id": "C1842747", "name": "C1842747#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0295734", "name": "C0295734#ent", "pos": [24, 25]}}
{"token": ["However", ",", "a", "supplement", "of", "PKC", "inhibitor", ",", "C0054537#ent", "<e1>", "after", "50", "microM", "C1413043#ent", "<e2>", "+", "ionophore", "treatment", ",", "was", "sufficient", "to", "inhibit", "the", "inactivation", "of", "MAP", "kinase", "pronuclear", "formation", "the", "oocytes", "."], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [13, 14]}}
{"token": ["The", "authors", "report", "the", "clinical", "findings", "a", "unique", "case", "of", "rapid", "C0948284#ent", "<e1>", "association", "with", "C0019937#ent", "<e2>"], "h": {"id": "C0948284", "name": "C0948284#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0019937", "name": "C0019937#ent", "pos": [15, 16]}}
{"token": ["We", "analyzed", "the", "importance", "of", "these", "pathways", "in", "the", "mouse", "by", "comparing", "LDL", "binding", "to", "primary", "cultures", "hepatocytes", "from", "C1366529#ent", "<e1>", "knockout", "(", "C1366529#ent", "<e1>", "C4284124#ent", "<e1>", ")", "and", "normal", "C57BL/6J", "mice"], "h": {"id": "C1366529", "name": "C1366529#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [25, 26]}}
{"token": ["Cells", "with", "mutant", "C1537502#ent", "<e1>", "had", "significantly", "lower", "amounts", "of", "C1743497#ent", "<e2>", "MnSOD", ")", "vs", "those", "with", "wild-type", "C1537502#ent", "<e1>", ",", "but", "MnSOD", "protein", "correlated", "positively", "with", "superoxide", "levels"], "h": {"id": "C1743497", "name": "C1743497#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [3, 4]}}
{"token": ["The", "recent", "molecular", "cloning", "the", "TNF-a", "converting", "enzyme", "(", "TACE", ")", "revealed", "that", "this", "shedding", "enzyme", "belongs", "to", "a", "family", "of", "C0025543#ent", "<e1>", "which", "contain", "a", "disintegrin", "domain", "C1332023#ent", "<e2>", "."], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [21, 22]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1332023", "name": "C1332023#ent", "pos": [28, 29]}}
{"token": ["GHR", "cleavage/GHBP", "shedding", "is", "effected", "by", "TACE", "(", "TNF-alpha", "converting", "enzyme", ")", ",", "a", "C0025543#ent", "<e1>", "of", "the", "C1332023#ent", "<e2>", "and", "possibly", "related", "enzymes", "."], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1332023", "name": "C1332023#ent", "pos": [18, 19]}}
{"token": ["These", "results", "demonstrate", "that", "LKB1", "and", "C1418779#ent", "<e1>", "abundances", "increase", "with", "endurance", "and", "interval", "training", "to", "C0008855#ent", "<e2>"], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008855", "name": "C0008855#ent", "pos": [16, 17]}}
{"token": ["Cyclosporin", "A", "C0280858#ent", "<e1>", ",", "vinblastine", ",", "and", "C0009262#ent", "<e2>", "inhibited", "cross-linking", "of", "mutants", "F343C/M986C", ",", "G346C/G989C", ",", "and", "P350C/S993C", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [8, 9]}}
{"token": ["D-alpha-Tocopherol", "=", "vitamin", "E", "C0031669#ent", "<e1>", ")", "was", "able", "to", "reduce", "C3538729#ent", "<e2>", "and", "DEA", "toxicity", "in", "cell", "cultures"], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538729", "name": "C3538729#ent", "pos": [11, 12]}}
{"token": ["An", "interesting", "observation", "is", "that", "C0026918#ent", "<e1>", "candida", "vaginitis", "rare", ",", "while", "coinfection", "between", "other", "types", "of", "C0042267#ent", "<e2>", "is", "common", "."], "h": {"id": "C0026918", "name": "C0026918#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042267", "name": "C0042267#ent", "pos": [17, 18]}}
{"token": ["Human", "C1425144#ent", "<e1>", "is", "a", "protein", "associated", "with", "juvenile", "NPH", ",", "an", "C3899988#ent", "<e2>", "inherited", "kidney", "disease", "for", "chronic", "renal", "failure", "children", "."], "h": {"id": "C1425144", "name": "C1425144#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [12, 13]}}
{"token": ["Abnormal", "respiratory", "function", "tests", "5", "other", "patients", "without", "any", "respiratory", "symptom", "that", "subclinical", "and", "subradiological", "lesions", "of", "the", "lungs", "and", "C0006267#ent", "<e1>", "are", "not", "uncommon", "in", "C0151449#ent", "<e2>"], "h": {"id": "C0006267", "name": "C0006267#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [26, 27]}}
{"token": ["These", "data", "demonstrate", "that", "SC", "can", "be", "compared", "to", "the", "classical", "hapten", "virus", "self-mediated", "cytotoxicity", ",", "but", "in", "this", "case", "C1420709#ent", "<e1>", "plays", "the", "role", "of", "these", "C0991617#ent", "<e2>", "."], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [27, 28]}}
{"token": ["However", ",", "the", "place", "of", "intermittent", "C0017887#ent", "<e1>", "the", "treatment", "of", "C0002965#ent", "<e2>", "clarification", "with", "further", "study", ",", "particularly", "comparisons", "with", "other", "long-acting", "forms", "of", "nitrates", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [11, 12]}}
{"token": ["The", "influence", "of", "indomethacin", "therapy", "on", "the", "circulatory", "and", "antianginal", "effects", "C0017887#ent", "<e1>", "were", "studied", "in", "six", "patients", "with", "C0002965#ent", "<e2>"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [19, 20]}}
{"token": ["The", "use", "of", "low", "molecular", "weight", "C0054452#ent", "<e1>", "for", "the", "prevention", "of", "C0010072#ent", "<e2>", "attention", "because", "of", "the", "pharmacological", "and", "pharmacokinetic", "properties", "of", "these", "products", "."], "h": {"id": "C0054452", "name": "C0054452#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0010072", "name": "C0010072#ent", "pos": [12, 13]}}
{"token": ["The", "material", ",", "definition", ",", "delimitation", ",", "and", "classification", "of", "C0178782#ent", "<e1>", "general", "data", "hereditary", "conditions", "and", "previous", "C0029896#ent", "<e2>", "have", "been", "discussed", "in", "a", "preceding", "study", "."], "h": {"id": "C0178782", "name": "C0178782#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [18, 19]}}
{"token": ["Experience", "of", "the", "modality", "in", "other", "C0037274#ent", "<e1>", "limited", ";", "areas", "where", "there", "is", "potential", "benefit", "include", "C0043037#ent", "<e2>", "acne", ",", "psoriasis", "and", "cutaneous", "T-cell", "lymphoma"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0043037", "name": "C0043037#ent", "pos": [17, 18]}}
{"token": ["We", "report", "here", "that", "PP1", "is", "required", "for", "dephosphorylation", "of", "the", "Cdc2-directed", "phosphatase", "Cdc25", "Ser287", "(", "of", "C1413259#ent", "<e1>", "Ser216", "of", "human", "C1528280#ent", "<e2>", ")", ",", "a", "site", "that", "suppresses", "Cdc25", "during", "interphase", "."], "h": {"id": "C1413259", "name": "C1413259#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1528280", "name": "C1528280#ent", "pos": [22, 23]}}
{"token": ["C3476424#ent", "<e1>", "PML", ")", "is", "a", "C0536221#ent", "<e2>", "plays", "essential", "roles", "in", "cell", "growth", "regulation", "apoptosis", ",", "transcriptional", "regulation", "and", "genome", "stability"], "h": {"id": "C3476424", "name": "C3476424#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [6, 7]}}
{"token": ["C0057472#ent", "<e1>", "treatment", "of", "membrane", "reduced", "the", "affinity", "(", "C1839259#ent", "<e2>", ")", "and", "the", "total", "binding", "R", ")", "of", "the", "agonist", "and", "the", "antagonist", "."], "h": {"id": "C0057472", "name": "C0057472#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [9, 10]}}
{"token": ["Human", "topoisomerase", "IIalpha", "TOP2A", ")", "is", "encoded", "by", "the", "TOP2A", "gene", "chromosome", "17q21", "22", ",", "and", "human", "topoisomerase", "IIbeta", "C1336658#ent", "<e1>", ")", "is", "encoded", "by", "the", "C1504636#ent", "<e2>", "chromosome", "3p24"], "h": {"id": "C1336658", "name": "C1336658#ent", "pos": [19, 20]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1504636", "name": "C1504636#ent", "pos": [26, 27]}}
{"token": ["Oxygen", "uptake", "the", "C4049625#ent", "<e1>", ",", "RCP", ",", "P1", "and", "C1419693#ent", "<e2>", "decreased", "in", "magnitude", "first", "in", "the", "active", "normal", ",", "then", "in", "sedentary", "normal", "subjects", "and", "finally", "in", "the", "heart", "failure", "patients", "."], "h": {"id": "C4049625", "name": "C4049625#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419693", "name": "C1419693#ent", "pos": [10, 11]}}
{"token": ["We", "believe", "that", "this", "association", "of", "congenital", "hypoparathyroidism", "severe", "C0015544#ent", "<e1>", "dysmorphism", "represents", "a", "new", "C1848862#ent", "<e2>", "."], "h": {"id": "C0015544", "name": "C0015544#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [15, 16]}}
{"token": ["Implicit", "in", "these", "findings", "are", "the", "possibilities", "that", "infants", "at", "risk", "of", "C0015544#ent", "<e1>", "can", "be", "identified", ",", "and", "measures", "to", "prevent", "this", "C1848862#ent", "<e2>", "can", "be", "introduced", "."], "h": {"id": "C0015544", "name": "C0015544#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [23, 24]}}
{"token": ["Rhodopsin", "regeneration", "attachment", "between", "the", "retinal", "pigment", "epithelium", "RPE", ")", "and", "rod", "outer", "segments", "however", ",", "in", "experimentally", "induced", "retinal", "detachment", "C1419385#ent", "<e1>", "be", "restored", "partially", "upon", "addition", "of", "C1708152#ent", "<e2>", "(", "interphotoreceptor", "retinoid", "binding", "protein", "."], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1708152", "name": "C1708152#ent", "pos": [29, 30]}}
{"token": ["Resolution", "of", "C0023530#ent", "<e1>", "was", "associated", "with", "disappearance", "or", "marked", "reduction", "in", "C0015923#ent", "<e2>", "ligand", "levels", "in", "10", "of", "11", "treated", "patients", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015923", "name": "C0015923#ent", "pos": [12, 13]}}
{"token": ["To", "demonstrate", "the", "utility", "of", "accurate", "clinical", "and", "electroencephalographic", "characterization", "of", "provoked", "cataplexy", "C0302539#ent", "<e1>", "in", "the", "diagnosis", "of", "C1834372#ent", "<e2>", "."], "h": {"id": "C0302539", "name": "C0302539#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1834372", "name": "C1834372#ent", "pos": [19, 20]}}
{"token": ["Gel", "retardation", "DNase", "I", "protection", "assays", "that", "EGR1", "C1421688#ent", "<e1>", "specifically", "to", "the", "C1335085#ent", "<e2>", "promoter", "region", "EGR", "consensus", "sequence"], "h": {"id": "C1421688", "name": "C1421688#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335085", "name": "C1335085#ent", "pos": [13, 14]}}
{"token": ["This", "confusion", "has", "led", "us", "to", "investigate", "the", "pharmacological", "activity", "the", "norephedrine", "(", "NOR", ")", "and", "C0069021#ent", "<e1>", "(", "NORP", ")", "isomers", "in", "the", "cardiovascular", "system", "the", "C0041964#ent", "<e2>", ":", "chloralose", "anesthetized", "rat", "."], "h": {"id": "C0069021", "name": "C0069021#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0041964", "name": "C0041964#ent", "pos": [27, 28]}}
{"token": ["Serum", ",", "urine", ",", "and", "C3540613#ent", "<e1>", "levels", "as", "well", "as", "renal", "creatinine", "C3540613#ent", "<e1>", "clearance", "and", "fractional", "excretion", "rates", "compared", "in", "25", "C0003873#ent", "<e1>", "patients", "and", "20", "age-", "and", "gender-matched", "healthy", "controls"], "h": {"id": "C3540613", "name": "C3540613#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [23, 24]}}
{"token": ["The", "incorporation", "results", "did", "not", "indicate", "an", "inability", "of", "normal", "collagen", "i.e.", "C0024341#ent", "<e1>", "the", "normal", "degree", ",", "to", "cross-link", "in", "C0036474#ent", "<e2>", "."], "h": {"id": "C0024341", "name": "C0024341#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036474", "name": "C0036474#ent", "pos": [21, 22]}}
{"token": ["In", "view", "of", "these", "findings", "we", "suggest", "that", "low-dose", "C0007804#ent", "<e1>", "may", "not", "be", "the", "best", "treatment", "for", "C0027538#ent", "<e2>"], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027538", "name": "C0027538#ent", "pos": [18, 19]}}
{"token": ["Assays", "of", "serum", "immunoreactive", "parathyroid", "hormone", "clinically", "useful", "in", "the", "differential", "diagnosis", "C0149911#ent", "<e1>", "states", "and", "in", "the", "assessment", "of", "the", "severity", "of", "C0040128#ent", "<e2>", "uraemic", "patients", "."], "h": {"id": "C0149911", "name": "C0149911#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [23, 24]}}
{"token": ["The", "leukotriene", "receptor", "antagonists", "C0298130#ent", "<e1>", ",", "zafirlukast", "and", "pranlukast", "inhibit", "bronchoconstriction", "in", "C0004096#ent", "<e2>", "patients", "undergoing", "allergen", ",", "exercise", ",", "cold", "air", "aspirin", "challenge", "."], "h": {"id": "C0298130", "name": "C0298130#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}}
{"token": ["The", "mitochondrial", "membrane", "potential", "measured", "in", "isolated", "rat", "kidney", "mitochondria", "and", "in", "digitonin-permeabilized", "MDCK", "type", "II", "cells", "pre-energized", "with", "succinate", ",", "C0017789#ent", "<e1>", ",", "and/or", "malate", "was", "reduced", "by", "micromolar", "C0700583#ent", "<e2>", "dose-dependently", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [30, 31]}}
{"token": ["Tuberculous", "discitis", "less", "common", "than", "C0012624#ent", "<e1>", "due", "to", "C1692886#ent", "<e2>"], "h": {"id": "C0012624", "name": "C0012624#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1692886", "name": "C1692886#ent", "pos": [9, 10]}}
{"token": ["To", "document", "the", "response", "to", "C0038317#ent", "<e1>", "in", "patients", "remaining", "C1416536#ent", "<e2>", "following", "endoscopic", "nasal", "sinus", "polypectomy"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416536", "name": "C1416536#ent", "pos": [10, 11]}}
{"token": ["The", "syntheses", "of", "C0246283#ent", "<e1>", ",", "parkinsonin", "A", "isoswertiajaponin", ",", "and", "C0242422#ent", "<e2>", "which", "are", "8-C-beta-D-glucopyranosyl-3',4',5,7-tetrahydroxyflavone", ",", "5-methyl", "orientin", ",", "7-methyl", "orientin", ",", "and", "5,7-dimethyl", "orientin", ",", "respectively", ",", "are", "reported", "herein", "."], "h": {"id": "C0246283", "name": "C0246283#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [11, 12]}}
{"token": ["Long-term", "administration", "of", "C0050451#ent", "<e1>", "dogs", "with", "experimentally", "induced", "urease-positive", "staphylococcal", "C0042029#ent", "<e2>", "struvite", "urolithiasis", "resulted", "in", "dose-dependent", "inhibition", "of", "urolith", "growth", "urolith", "dissolution", "."], "h": {"id": "C0050451", "name": "C0050451#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [11, 12]}}
{"token": ["Because", "of", "its", "rapid", "action", ",", "C0171637#ent", "<e1>", "might", "be", "a", "promising", "C3536865#ent", "<e2>", "treatment", "of", "APTE", "."], "h": {"id": "C0171637", "name": "C0171637#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536865", "name": "C3536865#ent", "pos": [12, 13]}}
{"token": ["HIV-1", "C0017356#ent", "<e1>", "is", "the", "C0086903#ent", "<e2>", "expressed", "earliest", "and", "most", "abundantly", "in", "the", "infection", "cycle"], "h": {"id": "C0017356", "name": "C0017356#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [5, 6]}}
{"token": ["Increased", "concentrations", "of", "C3539604#ent", "<e1>", "were", "demonstrated", "in", "plasma", "from", "patients", "with", "primary", "biliary", "cirrhosis", "C0008312#ent", "<e2>", ")", ",", "indicating", "in", "vivo", "activation", "of", "C3", "."], "h": {"id": "C3539604", "name": "C3539604#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "both", "cases", "of", "C1704715#ent", "<e1>", "were", "negative", "for", "CK5/6", "and", "C2984561#ent", "<e2>", "and", "were", "diffusely", "positive", "for", "CK7", "."], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2984561", "name": "C2984561#ent", "pos": [13, 14]}}
{"token": ["FPL", "55712", ",", "the", "SRS-A", "antagonist", ",", "was", "found", "to", "inhibit", "the", "formation", "of", "C0003693#ent", "<e1>", "but", "not", "the", "C0033551#ent", "<e2>"], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [19, 20]}}
{"token": ["The", "need", "to", "monitor", "blood", "pressure", "introduction", "of", "C0006938#ent", "<e1>", "the", "treatment", "of", "C0018802#ent", "<e2>", "infants", "is", "demonstrated", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["The", "C1456795#ent", "<e1>", "group", "had", "significantly", "higher", "C0002484#ent", "<e2>", "bilirubin", "levels", "LT", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002484", "name": "C0002484#ent", "pos": [7, 8]}}
{"token": ["C0023522#ent", "<e1>", "a", "well", "know", "side", "effect", "C0025677#ent", "<e2>", ",", "especially", "in", "conjunction", "with", "intrathecal", "administration", "whole", "brain", "radio", "therapy"], "h": {"id": "C0023522", "name": "C0023522#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [7, 8]}}
{"token": ["In", "human", "hepatocytes", ",", "usnic", "acid", "20", "microM", "was", "not", "an", "inducer", "of", "CYP1A2", ",", "CYP2B6", ",", "or", "C1142644#ent", "<e1>", "relative", "to", "positive", "controls", "C0028978#ent", "<e2>", ",", "phenobarbital", ",", "and", "rifampicin", ",", "respectively", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [18, 19]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [24, 25]}}
{"token": ["We", "therefore", "propose", "the", "existence", "of", "a", "mitochondrial", "pyruvate", "dehydrogenase", "bypass", "from", "the", "cytosolic", "one", ",", "where", "pyruvate", "is", "decarboxylated", "to", "acetaldehyde", "in", "the", "cytosol", "by", "C0034340#ent", "<e1>", "then", "oxidized", "by", "C4083146#ent", "<e2>"], "h": {"id": "C0034340", "name": "C0034340#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C4083146", "name": "C4083146#ent", "pos": [31, 32]}}
{"token": ["Each", "year", "more", "than", "2", "million", "children", "die", "from", "C1290807#ent", "<e1>", "the", "same", "number", "again", "die", "from", "C0339901#ent", "<e2>"], "h": {"id": "C1290807", "name": "C1290807#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0339901", "name": "C0339901#ent", "pos": [17, 18]}}
{"token": ["C0014335#ent", "<e1>", "assessed", "by", "C0027021#ent", "<e2>", "(", "MPO", ")", "activity", "in", "ileal", "muscle", "mounts", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [4, 5]}}
{"token": ["Certain", "antibiotics", ",", "most", "notably", "C0949665#ent", "<e1>", "such", "as", "ciprofloxacin", ",", "can", "induce", "an", "C4225412#ent", "<e2>", "response", "and", "can", "modulate", "the", "spread", "of", "virulence", "factors", "drug", "resistance"], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4225412", "name": "C4225412#ent", "pos": [14, 15]}}
{"token": ["We", "previously", "demonstrated", "that", "C1417668#ent", "<e1>", "NFLC", ")", "gene", "induction", "NGF", "requires", "collaborative", "extracellular", "signal-regulated", "kinase", "C1705791#ent", "<e2>", ")", "and", "c-Jun", "N-terminal", "kinase", "JNK", ")", "signaling", "."], "h": {"id": "C1417668", "name": "C1417668#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [16, 17]}}
{"token": ["Treating", "elderly", "patients", "with", "C0081876#ent", "<e1>", "(", "Protonix", ")", "after", "resolution", "of", "C0014868#ent", "<e2>", "results", "in", "fewer", "relapses", "than", "with", "placebo", "(", "SOR", ":", "B", ",", "double-blind", "RCT", "."], "h": {"id": "C0081876", "name": "C0081876#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0014868", "name": "C0014868#ent", "pos": [12, 13]}}
{"token": ["Cervical", "angina", "defined", "as", "a", "C0423738#ent", "<e1>", "resembles", "true", "cardiac", "angina", "by", "C0038019#ent", "<e2>"], "h": {"id": "C0423738", "name": "C0423738#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038019", "name": "C0038019#ent", "pos": [12, 13]}}
{"token": ["It", "was", "found", "that", "C0003596#ent", "<e1>", "significantly", "inhibited", "the", "carcinogenic", "effect", "of", "NDEA", "and", "neoplastic", "transformation", "C0669372#ent", "<e2>", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [16, 17]}}
{"token": ["To", "understand", "the", "role", "of", "the", "C3274871#ent", "<e1>", "leukemia", ",", "we", "must", "understand", "the", "normal", "functions", "C1423088#ent", "<e2>", "and", "MKL", "."], "h": {"id": "C3274871", "name": "C3274871#ent", "pos": [6, 7]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1423088", "name": "C1423088#ent", "pos": [16, 17]}}
{"token": ["ABT-299", "is", "a", "prodrug", "that", "is", "converted", "by", "C0014894#ent", "<e1>", "a", "potent", "platelet", "activating", "factor", "PAF", ")", "antagonist", "(", "C0296964#ent", "<e2>", ")", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0296964", "name": "C0296964#ent", "pos": [19, 20]}}
{"token": ["p56(lck", ")", "utilizes", "Shc", "and", "Grb2", "adaptors", "to", "mediate", "activation", "of", "C0079471#ent", "<e1>", "the", "thymoblast", "lines", "by", "promoting", "tyrosine", "phosphorylation", "the", "C1335822#ent", "<e2>", "constitutive", "interaction", "between", "Shc", "and", "Grb2", "."], "h": {"id": "C0079471", "name": "C0079471#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335822", "name": "C1335822#ent", "pos": [21, 22]}}
{"token": ["Nafamostat", "mesilate", "FUT-175", ")", "is", "a", "strong", "C3536890#ent", "<e1>", "is", "used", "as", "an", "C0003280#ent", "<e2>", "in", "extracorporeal", "circulation"], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [13, 14]}}
{"token": ["One", "hundred", "thirteen", "were", "treated", "at", "presentation", "with", "short", "courses", "of", "chemotherapy", ",", "most", "often", "with", "C0008163#ent", "<e1>", "bulky", "stage", "II", "and", "stages", "III", "C0012634#ent", "<e2>"], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [24, 25]}}
{"token": ["C0008163#ent", "<e1>", "was", "effective", "on", "both", "C0012634#ent", "<e2>", "."], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [6, 7]}}
{"token": ["Most", "compounds", "did", "not", "differentiate", "between", "5-HT1D", "alpha", "5-HT1D", "beta", "receptors", "except", "methysergide", ",", "ritanserin", ",", "C0133602#ent", "<e1>", ",", "risperidone", ",", "and", "C1517662#ent", "<e2>", ",", "which", "showed", "10", "-", "60-fold", "higher", "affinity", "for", "the", "5-HT1D", "alpha", "receptor"], "h": {"id": "C0133602", "name": "C0133602#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1517662", "name": "C1517662#ent", "pos": [22, 23]}}
{"token": ["AF9", "sequences", "fused", "into", "the", "mouse", "C0919528#ent", "<e1>", "that", "expression", "of", "the", "C3274682#ent", "<e2>", "fusion", "gene", "occurred", "from", "endogenous", "Mll", "transcription", "control", "elements", "as", "in", "t(9;11", ")", "found", "in", "human", "leukemias"], "h": {"id": "C0919528", "name": "C0919528#ent", "pos": [6, 7]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274682", "name": "C3274682#ent", "pos": [12, 13]}}
{"token": ["The", "expression", "of", "some", "nuclear", "genes", "Saccharomyces", "cerevisiae", "such", "as", "the", "C1420244#ent", "<e1>", "which", "encodes", "a", "glyoxylate", "cycle", "isoform", "of", "C1413745#ent", "<e2>", "is", "responsive", "to", "the", "functional", "state", "of", "mitochondria", "."], "h": {"id": "C1420244", "name": "C1420244#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413745", "name": "C1413745#ent", "pos": [20, 21]}}
{"token": ["Biological", "activity", "the", "follicle-stimulating", "hormone", "FSH", ")", "is", "dependent", "on", "its", "pattern", "of", "glycosylation", "and", "is", "altered", "during", "C0016952#ent", "<e1>", ",", "a", "genetic", "disease", "by", "deficient", "activity", "of", "galactose-1-phosphate", "uridyltransferase", "C0268151#ent", "<e2>", ")", "."], "h": {"id": "C0016952", "name": "C0016952#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0268151", "name": "C0268151#ent", "pos": [30, 31]}}
{"token": ["Heart", "transplantation", "C1415817#ent", "<e1>", ")", "is", "associated", "with", "reduction", "in", "bone", "mineral", "density", "C1826421#ent", "<e2>", ")", "."], "h": {"id": "C1415817", "name": "C1415817#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826421", "name": "C1826421#ent", "pos": [13, 14]}}
{"token": ["In", "response", "to", "C0162316#ent", "<e1>", "Arabidopsis", "roots", "induce", "the", "expression", "of", "the", "divalent", "cation", "transporter", "C1412299#ent", "<e2>", "."], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412299", "name": "C1412299#ent", "pos": [15, 16]}}
{"token": ["C0249866#ent", "<e1>", "homologous", "to", "other", "known", "protein", "kinases", "contains", "all", "nine", "invariant", "C3539946#ent", "<e2>", "in", "the", "catalytic", "domain", "this", "class", "of", "enzymes", "."], "h": {"id": "C0249866", "name": "C0249866#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [12, 13]}}
{"token": ["The", "presence", "of", "cysteine-241", "in", "C1412299#ent", "<e1>", "also", "explains", "the", "selective", "sensitivity", "of", "this", "C0597979#ent", "<e2>", "to", "inhibition", "by", "p-chloromercuribenzoate", "."], "h": {"id": "C1412299", "name": "C1412299#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597979", "name": "C0597979#ent", "pos": [14, 15]}}
{"token": ["We", "report", "on", "four", "patients", "who", "developed", "life-threatening", "C3536863#ent", "<e1>", "disturbances", "following", "treatment", "with", "C0014027#ent", "<e2>", "for", "severe", "cardiac", "failure", "NYHA-class", "II-IV", ")", "."], "h": {"id": "C3536863", "name": "C3536863#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014027", "name": "C0014027#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "we", "show", "that", "platelet", "C1413221#ent", "<e1>", "possesses", "NAD", "glycohydrolase", "ADP-ribose", "cyclase", "and", "C2827388#ent", "<e2>", "activities", "."], "h": {"id": "C1413221", "name": "C1413221#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2827388", "name": "C2827388#ent", "pos": [14, 15]}}
{"token": ["The", "portion", "of", "C1333229#ent", "<e1>", "which", "encodes", "the", "C1442905#ent", "<e2>", "in", "plants", "differs", "from", "that", "of", "C1333229#ent", "<e1>", "of", "animals", "and", "lower", "eukaryotes", "."], "h": {"id": "C1333229", "name": "C1333229#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1442905", "name": "C1442905#ent", "pos": [8, 9]}}
{"token": ["pVHL", "also", "ubiquitylates", "the", "large", "subunit", "of", "RNA", "polymerase", "II", "C1333229#ent", "<e1>", ",", "phosphorylated", "on", "serine", "5", "Ser5", ")", "within", "the", "C-terminal", "domain", "C1442905#ent", "<e2>", ")", "."], "h": {"id": "C1333229", "name": "C1333229#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1442905", "name": "C1442905#ent", "pos": [23, 24]}}
{"token": ["In", "cell", "culture", "isoproterenol", ",", "a", "C3536829#ent", "<e1>", "has", "been", "shown", "to", "upregulate", "thyroid", "hormone", "receptor", "C0040961#ent", "<e2>", ")", "mRNA", ",", "thus", "indicating", "a", "bi-directional", "regulation", "."], "h": {"id": "C3536829", "name": "C3536829#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "a", "chimeric", "protein", "prepared", "by", "C1516876#ent", "<e1>", "fusing", "the", "coding", "region", "the", "ricin", "A", "chain", "C1419304#ent", "<e2>", ")", "and", "the", "fragment", "A", "of", "diphtheria", "toxin", "DTA", ")", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419304", "name": "C1419304#ent", "pos": [17, 18]}}
{"token": ["To", "study", "the", "role", "of", "C1705084#ent", "<e1>", "in", "C0033860#ent", "<e2>", ",", "we", "engineered", "transgenic", "mice", "either", "a", "C1705084#ent", "<e1>", "non-risk", "allele", "or", "the", "C1705084#ent", "<e1>", "*"], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705084", "name": "C1705084#ent", "pos": [5, 6]}}
{"token": ["Because", "of", "the", "replacement", "of", "part", "of", "the", "C1827872#ent", "<e1>", "promoter", "by", "the", "corresponding", "region", "of", "C3714798#ent", "<e2>", ",", "the", "CYP3A7*1C", "allele", "the", "proximal", "ER6", "motif", "of", "C3714798#ent", "<e2>", "."], "h": {"id": "C1827872", "name": "C1827872#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [16, 17]}}
{"token": ["CYP3A5", "and", "C1827872#ent", "<e1>", ",", "but", "not", "C3714798#ent", "<e2>", ",", "were", "also", "expressed", "in", "the", "adrenal", "gland", "in", "the", "prostate", ",", "whereas", "only", "CYP3A5", "was", "detected", "in", "the", "kidney", "."], "h": {"id": "C1827872", "name": "C1827872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [7, 8]}}
{"token": ["Finally", ",", "we", "examined", "the", "coexpression", "of", "C1415065#ent", "<e1>", "with", "C1420718#ent", "<e2>", "cholecystokinin", "and", "demonstrate", "a", "high", "degree", "of", "C1415065#ent", "<e1>", "mRNA", "expression", "within", "dopaminergic", ",", "cholecystokinin-containing", "neurons", "of", "the", "substantia", "nigra", "ventral", "tegmental", "area"], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415065", "name": "C1415065#ent", "pos": [7, 8]}}
{"token": ["C1416475#ent", "<e1>", "activation", "required", "C1336666#ent", "<e2>", "and", "RIP1", ",", "but", "not", "TRAF2", "or", "TRAF3", "."], "h": {"id": "C1416475", "name": "C1416475#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336666", "name": "C1336666#ent", "pos": [4, 5]}}
{"token": ["TNF-alpha", "treatment", "resulted", "in", "increased", "C1705592#ent", "<e1>", "and", "ICAM-1", "protein", "mRNA", "synthesis", "increased", "C1705791#ent", "<e2>", "and", "p38", "activity", "and", "activation", "of", "the", "transcription", "factors", "activator", "protein-1", "AP-1", ")", "and", "nuclear", "factor-kappaB", "NF-kappaB", ")", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [13, 14]}}
{"token": ["Resistance", "to", "these", "compounds", "of", "C0017536#ent", "<e1>", "were", "described", "and", "in", "these", "cases", ",", "treatment", "by", "C0282331#ent", "<e2>", "or", "nitazoxanide", "are", "possible", "alternatives", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0282331", "name": "C0282331#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "a", "patient", "(", "W.B.", ")", "with", "chronic", "symptomatic", "C0017536#ent", "<e1>", "despite", "seven", "separate", "courses", "of", "either", "C0282331#ent", "<e2>", "or", "metronidazole", "who", "was", "cured", "by", "combined", "C0282331#ent", "<e2>", "and", "metronidazole", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0282331", "name": "C0282331#ent", "pos": [18, 19]}}
{"token": ["Activation", "of", "C1705628#ent", "<e1>", "and", "related", "pocket", "proteins", "p107/p130", "mediate", "attenuation", "of", "C1335227#ent", "<e2>", "."], "h": {"id": "C1705628", "name": "C1705628#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [12, 13]}}
{"token": ["Conversely", ",", "C1705628#ent", "<e1>", "loss", "deregulates", "the", "control", "of", "C1335227#ent", "<e2>", "expression", "."], "h": {"id": "C1705628", "name": "C1705628#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [9, 10]}}
{"token": ["To", "minimize", "tubule", "fluid", "C1166521#ent", "<e1>", "in", "an", "experimental", "model", "C0017658#ent", "<e2>", ",", "iron", "deficiency", "induced", "in", "rats", "prior", "to", "the", "induction", "of", "nephrotoxic", "serum", "nephritis"], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [10, 11]}}
{"token": ["C0406525#ent", "<e1>", "people", "with", "C0011847#ent", "<e2>", "result", "from", "repetitive", "stress", "by", "a", "lack", "of", "protective", "sensation"], "h": {"id": "C0406525", "name": "C0406525#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [4, 5]}}
{"token": ["Histone", "deacetylase", "inhibitors", "increased", "expression", "of", "SOX9", ",", "C1417574#ent", "<e1>", ",", "and", "PPARG", "and", "decreased", "C3274614#ent", "<e2>", "expression", "in", "clear", "cell", "sarcoma", "cells"], "h": {"id": "C1417574", "name": "C1417574#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3274614", "name": "C3274614#ent", "pos": [15, 16]}}
{"token": ["The", "method", "is", "simple", "and", "rapid", ",", "and", "it", "can", "be", "used", "for", "screening", "of", "C0039841#ent", "<e1>", "for", "clinical", "study", "various", "C0029896#ent", "<e2>", "related", "to", "vitamin", "B1", "deficiency"], "h": {"id": "C0039841", "name": "C0039841#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [21, 22]}}
{"token": ["Characterization", "of", "the", "metabolic", "defect", "TRMA", "may", "shed", "light", "on", "the", "role", "of", "C0039841#ent", "<e1>", "such", "common", "C0029896#ent", "<e2>", "."], "h": {"id": "C0039841", "name": "C0039841#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}}
{"token": ["The", "association", "of", "cancer", "with", "clinical", "abnormalities", "blood", "coagulation", "including", "C1510431#ent", "<e1>", "deep", "vein", "thrombosis", "DVT", ")", ",", "and", "disseminated", "intravascular", "coagulation", "C0010927#ent", "<e2>", ")", "is", "well-known", ",", "particularly", "in", "patients", "with", "solid", "tumors", "acute", "promyelocytic", "leukemia", "APL", ")", "."], "h": {"id": "C1510431", "name": "C1510431#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010927", "name": "C0010927#ent", "pos": [22, 23]}}
{"token": ["Insulin-like", "growth", "factor", "1", "C1334089#ent", "<e1>", ")", "is", "a", "major", "feedback", "regulator", "of", "pituitary", "C3539616#ent", "<e2>", "secretion", ",", "with", "defined", "actions", "occurring", "at", "both", "the", "hypothalamus", "and", "pituitary", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [14, 15]}}
{"token": ["Discrete", "C3539616#ent", "<e1>", "peaks", "stimulate", "linear", "(", "skeletal", ")", "growth", "and", "drive", "muscle", "C1334089#ent", "<e2>", "gene", "expression", "more", "effectually", "than", "basal", "(", "time-invariant", ")", "C3539616#ent", "<e1>", "exposure", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [1, 2]}}
{"token": ["Acceleration", "of", "growth", "was", "associated", "with", "stimulated", "C3539616#ent", "<e1>", "synthesis", "and", "C1334089#ent", "<e2>", "secretion", ",", "although", "basal", "serum", "C3539616#ent", "<e1>", "levels", "did", "not", "change", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [7, 8]}}
{"token": ["However", ",", "the", "C1334089#ent", "<e1>", "increment", "in", "response", "to", "C3539616#ent", "<e2>", "decreased", "after", "oral", "17beta-estradiol", "(", "P", "<", "0.05", ")", ",", "whereas", "it", "was", "unchanged", "after", "testosterone", "administration", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [9, 10]}}
{"token": ["The", "monitoring", "of", "UA", "level", "in", "less", "invasive", "biological", "samples", "as", "saliva", "is", "suggested", "for", "diagnosis", "and", "therapy", "of", "C0018099#ent", "<e1>", ",", "hyperuricemia", "and", "the", "C0023374#ent", "<e2>"], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [19, 20]}, "relation": "manifestation_of", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [25, 26]}}
{"token": ["Elevated", "levels", "in", "the", "range", "4.4", "-", "7.9", "nmol", "PP-ribose-P/ml", "packed", "RBC", "were", "found", "in", "four", "patients", "with", "C0018099#ent", "<e1>", "and", "partial", "deficiency", "the", "C0023374#ent", "<e2>"], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [18, 19]}, "relation": "manifestation_of", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [24, 25]}}
{"token": ["Extreme", "degrees", "hypoxanthine", "phosphoribosyltransferase", "HPRT", ")", "deficiency", "in", "man", "are", "associated", "with", "gross", "sex-linked", "neurological", "dysfunction", "C0018099#ent", "<e1>", "and", "urinary", "stones", "the", "C0023374#ent", "<e2>", "or", "'", "complete", "HPRT-deficiency", "'", "syndrome", ")", "."], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [22, 23]}}
{"token": ["Tinidazole", "as", "well", "as", "C0025872#ent", "<e1>", "is", "an", "excellent", "C0729502#ent", "<e2>", "anaerobic", "bacteria", "Propionibacterium", "acnes", "Bifidobacterium", "adolescentis"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [9, 10]}}
{"token": ["These", "results", "indicate", "that", "dimetridazole", ",", "C0025872#ent", "<e1>", "and", "mebendazole", "are", "the", "most", "effective", "C0729502#ent", "<e2>", "in", "vitro", "inhibiting", "the", "growth", "of", "S.", "vortens", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [14, 15]}}
{"token": ["In", "cultured", "rat", "aortic", "smooth", "muscle", "cells", "C1335631#ent", "<e1>", "activated", "by", "angiotensin", "II", "suppressed", "by", "the", "pretreatment", "with", "C0872972#ent", "<e2>", "and", "troglitazone", "."], "h": {"id": "C1335631", "name": "C1335631#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0872972", "name": "C0872972#ent", "pos": [18, 19]}}
{"token": ["Leg", "ulcers", "C0034150#ent", "<e1>", "similar", "to", "the", "manifestation", "of", "thrombotic", "thrombocytopenic", "purpura", "C0034155#ent", "<e2>", ")", ";", "disseminated", "intravascular", "coagulation", "and", "Henoch-Sch\u00f6nlein", "purpura", "occur", "."], "h": {"id": "C0034150", "name": "C0034150#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0034155", "name": "C0034155#ent", "pos": [12, 13]}}
{"token": ["Dihydrofolate", "reductase", "DHFR", ")", "from", "hamster", "cells", "a", "low", "or", "poor", "affinity", "to", "these", "C1413904#ent", "<e1>", "as", "compared", "to", "the", "hydrophilic", "folate", "antagonist", "methotrexate", "(", "C0025677#ent", "<e2>", ")", "."], "h": {"id": "C1413904", "name": "C1413904#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [25, 26]}}
{"token": ["FVII", "A294V", "shows", "delayed", "activation", "by", "C2700041#ent", "<e1>", "as", "well", "as", "reduced", "activity", "towards", "C2717827#ent", "<e2>", "and", "macromolecular", "substrates", "without", "impairing", "the", "catalytic", "efficiency", "of", "the", "triad", "."], "h": {"id": "C2700041", "name": "C2700041#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2717827", "name": "C2717827#ent", "pos": [14, 15]}}
{"token": ["C1098808#ent", "<e1>", "mRNA", "is", "expressed", "in", "C0669372#ent", "<e2>", "."], "h": {"id": "C1098808", "name": "C1098808#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [6, 7]}}
{"token": ["To", "evaluate", "the", "clinical", "effect", "quality", "of", "life", "C0518214#ent", "<e1>", ")", "in", "coronary", "artery", "bypass", "grafting", "CABG", ")", "patients", "treated", "according", "to", "C0039082#ent", "<e2>", "differentiation", "of", "TCM", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [22, 23]}}
{"token": ["The", "interior", "of", "the", "C0019348#ent", "<e1>", "capsid", "intermediate", "contains", "the", "C1947941#ent", "<e2>", "assembly", "protein", "compose", "the", "scaffold", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [10, 11]}}
{"token": ["It", "is", "well", "known", "that", "C0037116#ent", "<e1>", "is", "frequently", "accompanied", "with", "C0038013#ent", "<e2>", "probably", "due", "to", "the", "effects", "of", "silica", "on", "the", "immunological", "system"], "h": {"id": "C0037116", "name": "C0037116#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [11, 12]}}
{"token": ["It", "is", "well", "known", "that", "during", "long-term", "C0037116#ent", "<e1>", ",", "some", "autoimmune", "diseases", "such", "as", "systemic", "sclerosis", "systemic", "lupus", "erythematosus", "C0038013#ent", "<e2>", "can", "occur", "."], "h": {"id": "C0037116", "name": "C0037116#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [20, 21]}}
{"token": ["A", "method", "is", "presented", "for", "the", "simultaneous", "purification", "of", "hexokinase", ",", "fructose-bisphosphate", "aldolase", "C3887669#ent", "<e1>", "phosphoglycerate", "kinase", "and", "the", "partial", "purification", "of", "C1415199#ent", "<e2>", "NAD+", ")", ",", "6-phosphofructokinase", ",", "glucosephosphate", "isomerase", "and", "glycerol", "kinase", "Trypanosoma", "brucei"], "h": {"id": "C3887669", "name": "C3887669#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415199", "name": "C1415199#ent", "pos": [22, 23]}}
{"token": ["Western", "blot", "analysis", "the", "monoclonal", "antibody", "9A7", "gamma", "to", "C1706113#ent", "<e1>", "was", "performed", "on", "protein", "extracted", "from", "the", "C1855648#ent", "<e2>", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1855648", "name": "C1855648#ent", "pos": [18, 19]}}
{"token": ["Treatment", "of", "nude", "mice", "subcutaneously", "established", "HCC", "tumors", "with", "a", "combination", "of", "an", "C0001486#ent", "<e1>", "expressing", "RUNX3", "and", "C0014582#ent", "<e2>", "completely", "suppressed", "tumor", "growth"], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [18, 19]}}
{"token": ["C1423043#ent", "<e1>", "the", "decrease", "of", "DNMT1", "by", "C1705328#ent", "<e2>", "inhibition", ",", "suggesting", "that", "Gsk3beta", "mediated", "the", "stabilization", "of", "DNMT1", "by", "C1705328#ent", "<e2>", "."], "h": {"id": "C1423043", "name": "C1423043#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [7, 8]}}
{"token": ["Gsk3beta", "inhibitor", "the", "decrease", "of", "DNMT1", "by", "C1705328#ent", "<e1>", "inhibition", ",", "suggesting", "that", "C1423043#ent", "<e2>", "mediated", "the", "stabilization", "of", "DNMT1", "by", "C1705328#ent", "<e1>", "."], "h": {"id": "C1423043", "name": "C1423043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [7, 8]}}
{"token": ["We", "report", "2", "patients", "over", "the", "age", "of", "70", "who", ",", "while", "on", "C0037567#ent", "<e1>", "(", "VPA", ")", "for", "C0085417#ent", "<e2>", "developed", "sensorineural", "hearing", "loss"], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0085417", "name": "C0085417#ent", "pos": [19, 20]}}
{"token": ["Following", "combination", "of", "lidocaine", "and", "a", "IC", "agent", "7", "with", "encainide", "and", "5", "with", "C0016229#ent", "<e1>", ")", ",", "two", "had", "no", "C0042514#ent", "<e2>", "VT", ")", "and", "one", "had", "nonsustained", "VT", "NSVT", ")", "."], "h": {"id": "C0016229", "name": "C0016229#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0042514", "name": "C0042514#ent", "pos": [21, 22]}}
{"token": ["At", "18.00", "hr", "endogenous", "glucocorticoids", "do", "not", "regulate", "oestrogen-stimulated", "C1418938#ent", "<e1>", "release", ",", "although", "C0020402#ent", "<e2>", "is", "inhibitory", "through", "EOPs", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [14, 15]}}
{"token": ["Deletion", "of", "C1335222#ent", "<e1>", "or", "overexpression", "of", "C1706042#ent", "<e2>", "can", "partially", "suppress", "the", "S-phase", "defect", "cak1", "mutant", "cells", "suggesting", "that", "Ime2p", "is", "a", "key", "target", "of", "Cak1p", "regulation", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706042", "name": "C1706042#ent", "pos": [7, 8]}}
{"token": ["Regulation", "of", "the", "synthesis", "and", "release", "of", "C0030956#ent", "<e1>", "by", "the", "melanotropic", "cells", "the", "intermediate", "lobe", "the", "murine", "C0342409#ent", "<e2>", "is", "mainly", "brought", "about", "by", "innervation", "of", "the", "lobe", "by", "dopaminergic", "and", "GABAergic", "fibres"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342409", "name": "C0342409#ent", "pos": [18, 19]}}
{"token": ["Among", "biological", "factors", "authors", "stress", "the", "importance", "of", "the", "epileptogenic", "threshold", "and", "of", "measuring", "plasma", "levels", "of", "C0030956#ent", "<e1>", "released", "by", "the", "posterior", "lobe", "C0342409#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0342409", "name": "C0342409#ent", "pos": [24, 25]}}
{"token": ["Fourteen", "environmental", "parameters", "were", "defined", "that", "described", "herd", "environment", ",", "such", "as", "average", "protein", "production", "average", "somatic", "cell", "score", "C0175699#ent", "<e1>", ")", ",", "average", "calving", "interval", ",", "and", "average", "body", "condition", "score", "C1412777#ent", "<e2>", ")", "."], "h": {"id": "C0175699", "name": "C0175699#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412777", "name": "C1412777#ent", "pos": [32, 33]}}
{"token": ["Immune", "complex", "renal", "diseases", "such", "as", "C0017662#ent", "<e1>", "may", "be", "related", "to", "biologic", "response", "C0035064#ent", "<e2>", "in", "patients", "with", "HIV", "infection"], "h": {"id": "C0017662", "name": "C0017662#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}}
{"token": ["Any", "deterioration", "in", "the", "surfactant", "system", "results", "in", "functional", "consequences", "for", "lung", "mechanics", "C0719022#ent", "<e1>", "clearance", "mechanisms", "as", "discussed", "for", "RDS", "and", "C0041912#ent", "<e2>", "."], "h": {"id": "C0719022", "name": "C0719022#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [22, 23]}}
{"token": ["The", "concentrations", "in", "lung", ",", "pleural", "and", "C0719022#ent", "<e1>", "probably", "permit", "low", "doses", "the", "treatment", "of", "most", "C0041912#ent", "<e2>"], "h": {"id": "C0719022", "name": "C0719022#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [17, 18]}}
{"token": ["ERF", "and", "C1419039#ent", "<e1>", "genes", "were", "assigned", "to", "SSC4", "and", "C1422635#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1419039", "name": "C1419039#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422635", "name": "C1422635#ent", "pos": [10, 11]}}
{"token": ["C0019163#ent", "<e1>", "now", "the", "most", "commonly", "reported", "C0019159#ent", "<e2>", "in", "the", "United", "States", "the", "physician's", "infectious", "occupational", "hazard", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [7, 8]}}
{"token": ["Endogenous", "iron", "chelators", "as", "glutamate", ",", "citrate", ",", "aspartate", ",", "glycine", ",", "cysteine", ",", "dithiothreitol", ",", "C4285220#ent", "<e1>", ",", "ADP", "and", "C1705556#ent", "<e2>", "did", "not", "enhance", "iron-catalysed", "bleomycin-dependent", "degradation", "of", "DNA", "."], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [21, 22]}}
{"token": ["Among", "the", "nucleoside", "monophosphates", "C4285220#ent", "<e1>", ",", "CMP", ",", "GMP", "and", "UMP", ")", "investigated", ",", "only", "C4285220#ent", "<e1>", "reacted", "with", "C1705556#ent", "<e1>", "."], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [20, 21]}}
{"token": ["Transient", "expression", "in", "COS-7", "cells", "generated", "a", "5'-nucleotidase", "that", "catalyzed", "adenosine", "formation", "from", "C4285220#ent", "<e1>", ",", "which", "was", "increased", "during", "C1705556#ent", "<e2>", "catabolism", "."], "h": {"id": "C4285220", "name": "C4285220#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [20, 21]}}
{"token": ["The", "disease", "is", "characterized", "by", "intensive", "pain", "often", "radiating", "and", "migrating", ",", "and", "neurological", "deficits", "i.e.", "C0015469#ent", "<e1>", "as", "well", "as", "disseminated", "C0700594#ent", "<e2>", "."], "h": {"id": "C0015469", "name": "C0015469#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0700594", "name": "C0700594#ent", "pos": [22, 23]}}
{"token": ["The", "15-objects", "test", "scores", "of", "the", "C0242422#ent", "<e1>", "patients", "correlated", "significantly", "with", "both", "their", "intellectual", "impairment", "the", "severity", "of", "their", "C0242422#ent", "<e1>", "disability", ",", "but", "not", "with", "the", "C0720099#ent", "<e1>", "of", "the", "disease", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [28, 29]}}
{"token": ["Depressed", "and", "nondepressed", "C0242422#ent", "<e1>", "were", "also", "matched", "for", "C0720099#ent", "<e2>", "and", "severity", "of", "illness", ",", "and", "for", "the", "type", "of", "antiparkinsonian", "treatment", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [9, 10]}}
{"token": ["The", "second", "metacarpal-trapezoid", "ligament", "the", "third", "metacarpal-capitate", "ligament", "most", "closely", "approximated", "the", "C0427008#ent", "<e1>", "and", "strength", "of", "the", "C4049739#ent", "<e2>", "."], "h": {"id": "C0427008", "name": "C0427008#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4049739", "name": "C4049739#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "standard", "pharmacokinetic", "parameters", "for", "the", "C1254351#ent", "<e1>", "in", "this", "population", ",", "we", "administered", "C0006938#ent", "<e2>", ",", "1", "mg/kg", ",", "orally", "to", "10", "infants", "aged", "6.8", "+", "/-", "4.6", "months", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [15, 16]}}
{"token": ["The", "manidipine-induced", "increase", "of", "HO-1", "gene", "and", "protein", "expression", "to", "be", "a", "peculiar", "effect", "of", "this", "C1254351#ent", "<e1>", "since", "it", "is", "not", "observed", "with", "C0006938#ent", "<e2>", "and", "nifedipine", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [24, 25]}}
{"token": ["C0534191#ent", "<e1>", "corrects", "the", "deficient", "thrombin", "generation", "in", "C1366370#ent", "<e2>", "and", "FIX", "deficiency", "and", "in", "blood", "containing", "C1366370#ent", "<e2>", "inhibitors", "."], "h": {"id": "C0534191", "name": "C0534191#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [8, 9]}}
{"token": ["At", "present", ",", "C0534191#ent", "<e1>", "only", "approved", "for", "the", "treatment", "of", "C1366370#ent", "<e2>", "B", "patients", "who", "have", "acquired", "antibodies", "to", "Factors", "VIII", "and", "IX", "."], "h": {"id": "C0534191", "name": "C0534191#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [11, 12]}}
{"token": ["A", "significant", "association", "has", "been", "reported", "between", "a", "common", "variant", "in", "the", "angiotensinogen", "gene", "C1706480#ent", "<e1>", ")", ",", "allele", "T235", ",", "and", "C0085580#ent", "<e2>"], "h": {"id": "C1706480", "name": "C1706480#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [22, 23]}}
{"token": ["After", "intra", "cardiac", "repair", ",", "we", "administered", "2,000", "units", "of", "C1366370#ent", "<e1>", "followed", "by", "an", "injection", "of", "C0054756#ent", "<e2>", "and", "its", "level", "was", "240", "%", "at", "CCU", "."], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0054756", "name": "C0054756#ent", "pos": [17, 18]}}
{"token": ["The", "amyloid", "was", "identified", "by", "immunohistochemical", "technique", "related", "to", "C0010803#ent", "<e1>", "reactive", "with", "monoclonal", "antibodies", "AE1", "and", "C1420195#ent", "<e2>", "but", "not", "AE2", "."], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420195", "name": "C1420195#ent", "pos": [17, 18]}}
{"token": ["Based", "on", "their", "histochemical", "phenotype", ",", "ganglion", "cells", "C1417815#ent", "<e1>", "and", "TH", "could", "correspond", "to", "C0085648#ent", "<e2>", "neurons", "type", "I", "of", "the", "rat", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [15, 16]}}
{"token": ["The", "subsequent", "enzymatic", "reaction", "sequence", "conversion", "of", "phosphatidylglycerol", "to", "G-3-P", "by", "C0031670#ent", "<e1>", "glycerol", "kinase", "the", "presence", "of", "C2744579#ent", "<e2>", "."], "h": {"id": "C0031670", "name": "C0031670#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [18, 19]}}
{"token": ["Noradrenaline", "seems", "to", "rely", "on", "C0031670#ent", "<e1>", "mediate", "its", "contractile", "effects", "whilst", "C2744579#ent", "<e2>", "promotes", "both", "polyphosphoinositide", "and", "phosphatidylcholine", "metabolism", "that", "multiple", "signal-transduction", "mechanisms", "are", "involved", "in", "stimulus-contraction", "coupling", "in", "this", "artery", "."], "h": {"id": "C0031670", "name": "C0031670#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [12, 13]}}
{"token": ["C0013295#ent", "<e1>", "patients", "were", "given", "omeprazole", "20", "mg", "once", "daily", "or", "C2348248#ent", "<e2>", "30", "mg", "once", "daily", "for", "6", "weeks", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2348248", "name": "C2348248#ent", "pos": [11, 12]}}
{"token": ["All", "of", "the", "C0013295#ent", "<e1>", "healed", "within", "6", "weeks", "with", "omeprazole", "or", "C2348248#ent", "<e2>", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2348248", "name": "C2348248#ent", "pos": [12, 13]}}
{"token": ["To", "examine", "the", "possible", "beneficial", "effect", "of", "a", "new", "cerebral", "protection", "device", "based", "on", "balloon", "occlusion", "the", "C0751815#ent", "<e1>", "ICA", ")", "and", "debris", "aspiration", "patients", "undergoing", "carotid", "artery", "stenting", "C1366459#ent", "<e2>", ")", "."], "h": {"id": "C0751815", "name": "C0751815#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1366459", "name": "C1366459#ent", "pos": [29, 30]}}
{"token": ["Food", "particles", "nutritive", "values", "dried", "yeast", "wheat", "flour", "fishmeal", ",", "or", "dried", "blood", "were", "ingested", "faster", "than", "inert", "particles", "C0264435#ent", "<e1>", ",", "talc", ",", "chalk", ",", "or", "C0001275#ent", "<e2>", ")", "."], "h": {"id": "C0264435", "name": "C0264435#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0001275", "name": "C0001275#ent", "pos": [27, 28]}}
{"token": ["Ablation", "of", "C1333544#ent", "<e1>", "also", "failed", "to", "correct", "hypophosphatemia", "in", "C0813171#ent", "<e2>"], "h": {"id": "C1333544", "name": "C1333544#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0813171", "name": "C0813171#ent", "pos": [10, 11]}}
{"token": ["C0173083#ent", "<e1>", "has", "transformed", "the", "natural", "history", "C0268483#ent", "<e2>", "."], "h": {"id": "C0173083", "name": "C0173083#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0268483", "name": "C0268483#ent", "pos": [7, 8]}}
{"token": ["Two", "cases", "of", "C1562908#ent", "<e1>", "developed", "keratosis", "spinulosa", "the", "C0002932#ent", "<e2>", "during", "type", "I", "lepra", "reactions", "are", "described", "."], "h": {"id": "C1562908", "name": "C1562908#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002932", "name": "C0002932#ent", "pos": [9, 10]}}
{"token": ["Clarification", "of", "this", "point", "is", "important", "in", "hyperinsulinemic", "Watanabe", "heritable", "hyperlipidemic", "(", "C2827371#ent", "<e1>", ")", "rabbits", ",", "an", "animal", "model", "C0020445#ent", "<e2>", "as", "hypertension", "markedly", "stimulates", "atherosclerosis", "in", "C2827371#ent", "<e1>", "rabbits", "."], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2827371", "name": "C2827371#ent", "pos": [12, 13]}}
{"token": ["C1332805#ent", "<e1>", "one", "of", "the", "enzymes", "which", "participates", "in", "C0009325#ent", "<e2>", "degradation", "and", "activates", "precursor", "forms", "collagenolytic", "metalloproteinases"], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [9, 10]}}
{"token": ["C0014868#ent", "<e1>", "a", "common", "concomitant", "disease", "C0023530#ent", "<e2>", "patients", "after", "chemotherapie", "as", "well", "as", "in", "HIV-patients", "."], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [6, 7]}}
{"token": ["Four", "patients", "had", "bacteremic", "C0014868#ent", "<e1>", "all", "were", "immunocompromised", ",", "three", "by", "profound", "C0023530#ent", "<e2>", "and", "one", "by", "gestational", "prematurity"], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [13, 14]}}
{"token": ["The", "crystal", "structure", "C3541418#ent", "<e1>", "complexed", "with", "its", "C0030956#ent", "<e2>", "reveals", "that", "a", "hydrophobic", "pocket", "on", "Ydj1", "domain", "I", "may", "play", "a", "major", "role", "in", "mediating", "the", "interactions", "between", "C3541418#ent", "<e1>", "and", "the", "C0030956#ent", "<e2>"], "h": {"id": "C3541418", "name": "C3541418#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [8, 9]}}
{"token": ["TRH", "and", "EGF", "markedly", "decreased", "C0812231#ent", "<e1>", "binding", "in", "C0173879#ent", "<e2>", "GH3", "cells", ",", "whereas", ",", "they", "increased", "C0812231#ent", "<e1>", "binding", "in", "phosphatase", "inhibitor-treated", "GH3", "cells", "."], "h": {"id": "C0812231", "name": "C0812231#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0173879", "name": "C0173879#ent", "pos": [9, 10]}}
{"token": ["C0031849#ent", "<e1>", "is", "a", "C0002062#ent", "<e2>", "great", "interest", "as", "a", "therapeutic", "candidate", "for", "the", "treatment", "of", "Alzheimer's", "disease"], "h": {"id": "C0031849", "name": "C0031849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [4, 5]}}
{"token": ["Cells", "expressing", "the", "C1413623#ent", "<e1>", "mutant", "have", "attenuated", "C1321914#ent", "<e2>", "ruffling", "and", "slower", "cell", "speed"], "h": {"id": "C1413623", "name": "C1413623#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [8, 9]}}
{"token": ["C1947941#ent", "<e1>", "are", "attractive", "C3536844#ent", "<e2>", "targets", "because", "of", "their", "indispensable", "roles", "in", "parasite", "infection", "development", ",", "especially", "in", "the", "processes", "of", "host", "erythrocyte", "rupture/invasion", "and", "hemoglobin", "degradation"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536844", "name": "C3536844#ent", "pos": [4, 5]}}
{"token": ["In", "the", "neuromelanin-laden", "neurones", "of", "controls", ",", "C1415755#ent", "<e1>", "was", "nondetectable", ",", "whereas", "C1415764#ent", "<e2>", "was", "weakly", "expressed", "in", "both", "the", "cytosol", "and", "the", "nucleus", "."], "h": {"id": "C1415755", "name": "C1415755#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415764", "name": "C1415764#ent", "pos": [13, 14]}}
{"token": ["Pretreatment", "with", "sodium", "vanadate", "increased", "the", "fraction", "of", "apoptotic", "cells", ",", "slightly", "increased", "the", "level", "of", "C1415755#ent", "<e1>", "in", "the", "nonapoptotic", "cells", ",", "but", "did", "not", "affect", "C1415764#ent", "<e2>", "."], "h": {"id": "C1415755", "name": "C1415755#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415764", "name": "C1415764#ent", "pos": [27, 28]}}
{"token": ["Case", "2", "A", "60-year-old", "man", "with", "C0017531#ent", "<e1>", "proteinuria", "with", "renal", "dysfunction", "C0398650#ent", "<e2>", "antinuclear", "antibody", "anti-RNP", "antibody", "anti-DNA", "antibody", "anti-cardiolipin", "antibody"], "h": {"id": "C0017531", "name": "C0017531#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0398650", "name": "C0398650#ent", "pos": [12, 13]}}
{"token": ["Indeed", ",", "a", "C0669365#ent", "<e1>", "active", "NICD", "indiscriminately", "up-regulates", "expression", "of", "both", "HERP1", "and", "C3539571#ent", "<e2>", "mRNAs", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539571", "name": "C3539571#ent", "pos": [14, 15]}}
{"token": ["These", "highly", "active", "C0003392#ent", "<e1>", "be", "used", "for", "incorporation", "into", "targeted", "cytotoxic", "analogs", "of", "C1415169#ent", "<e2>", "for", "cancer", "therapy"], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [14, 15]}}
{"token": ["Leuprorelin", "acetate", "a", "C0003392#ent", "<e1>", "to", "treat", "prostate", "cancer", "is", "a", "C1415169#ent", "<e2>", "LHRH", ")", "agonist", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [11, 12]}}
{"token": ["The", "C2347168#ent", "<e1>", "U0126", ",", "effectively", "decreased", "C0298690#ent", "<e2>", "stimulated", "differentiation", "in", "ASB15-", "and", "ASB15Con", "cells", "."], "h": {"id": "C2347168", "name": "C2347168#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0298690", "name": "C0298690#ent", "pos": [7, 8]}}
{"token": ["The", "presence", "of", "C1412356#ent", "<e1>", "attenuated", "both", "the", "induced", "release", "of", "C0017789#ent", "<e2>", "and", "the", "increase", "in", "calcium", "content", "whereas", "5-", "or", "15-lipoxygenase", "metabolites", "ineffective", "."], "h": {"id": "C1412356", "name": "C1412356#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "this", "increase", "in", "PTHrP", "(", "but", "not", "that", "of", "C1419073#ent", "<e1>", ")", "was", "inhibited", "by", "the", "C1516869#ent", "<e2>", "losartan", "."], "h": {"id": "C1419073", "name": "C1419073#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [18, 19]}}
{"token": ["The", "mice", "devoid", "of", "normal", "C4082486#ent", "<e1>", "also", "more", "sensitive", "to", "the", "blocking", "effects", "of", "C0079245#ent", "<e2>", "and", "2-amino-5-phosphonopentanoic", "acid", "the", "hippocampal", "long-term", "potentiation", "generation", "."], "h": {"id": "C4082486", "name": "C4082486#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079245", "name": "C0079245#ent", "pos": [15, 16]}}
{"token": ["Raloxifene", "and", "C0139560#ent", "<e1>", "are", "selective", "estrogen", "receptor", "modulators", "SERMs", ")", "that", "exhibit", "tissue-specific", "C0243192#ent", "<e2>", "or", "antagonist", "properties", "via", "interactions", "with", "the", "estrogen", "receptor", "ER", ")", "."], "h": {"id": "C0139560", "name": "C0139560#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [14, 15]}}
{"token": ["C0139560#ent", "<e1>", "is", "an", "C0243192#ent", "<e2>", "through", "the", "estrogen", "response", "element", "ERE", ")", "and", "exhibits", "similar", "postreceptor", "effects", "to", "estrogen", "in", "bone-forming", "osteoblasts", "."], "h": {"id": "C0139560", "name": "C0139560#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}}
{"token": ["This", "alpha", "LCR", "fragment", "does", "not", "exhibit", "promoter", "specificity", "it", "can", "activate", "both", "the", "promoter", "of", "its", "endogenous", "target", "C0079429#ent", "<e1>", "and", "the", "heterologous", "promoter", "of", "the", "C1456377#ent", "<e2>", "early", "genes", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [27, 28]}}
{"token": ["Using", "clinical", "data", "repeated", "C0149931#ent", "<e1>", "attacks", "treated", "with", "placebo", ",", "C0540623#ent", "<e2>", "2.5", "mg", "or", "sumatriptan", "100", "mg", ",", "we", "show", "that", "attack", "and", "interictal", "periods", "can", "be", "described", "by", "a", "random", "probability", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0540623", "name": "C0540623#ent", "pos": [11, 12]}}
{"token": ["Our", "analysis", "of", "C1417111#ent", "<e1>", ";", "Meox2", "mutant", "mice", "supports", "this", "hypothesis", ",", "as", "C1412734#ent", "<e2>", "expression", "in", "the", "sclerotome", "is", "lost", "in", "the", "absence", "of", "both", "Meox", "proteins", "."], "h": {"id": "C1417111", "name": "C1417111#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412734", "name": "C1412734#ent", "pos": [14, 15]}}
{"token": ["A", "3'-->5", "'", "exonuclease", "found", "in", "rat", "C0023899#ent", "<e1>", "excises", "mispaired", "nucleotides", "the", "C0063125#ent", "<e2>", "end", "of", "primer", "chains", "as", "poly", "dA-d(T9-C", ")", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0063125", "name": "C0063125#ent", "pos": [13, 14]}}
{"token": ["Some", "of", "the", "patients", "were", "taking", "adrenergic", "blocking", "drugs", "C0033497#ent", "<e1>", "and", "phentolamine", ")", ",", "others", "were", "taking", "C0040613#ent", "<e2>", "and", "the", "rest", "were", "taking", "no", "drugs", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040613", "name": "C0040613#ent", "pos": [18, 19]}}
{"token": ["Using", "C0053104#ent", "<e1>", "to", "differentially", "block", "agonist", "effects", "of", "clonidine", "but", "not", "C0520472#ent", "<e2>", "it", "was", "shown", "that", "clonidine", "can", "competitively", "antagonize", "the", "effects", "of", "C0520472#ent", "<e2>", "."], "h": {"id": "C0053104", "name": "C0053104#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0520472", "name": "C0520472#ent", "pos": [12, 13]}}
{"token": ["More", "than", "40", "%", "of", "the", "women", "presented", "lower", "C0042075#ent", "<e1>", "or", "with", "haematuria", ",", "giving", "a", "clinical", "picture", "to", "C0010692#ent", "<e2>"], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0010692", "name": "C0010692#ent", "pos": [20, 21]}}
{"token": ["Brain", "capillaries", "that", "comprise", "the", "C1801950#ent", "<e1>", ",", "possess", "an", "endogenous", "receptor", "that", "ferries", "an", "iron-transport", "protein", "termed", "p97", "(", "C1417130#ent", "<e2>", ")", ",", "across", "the", "C1801950#ent", "<e1>", "."], "h": {"id": "C1417130", "name": "C1417130#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1801950", "name": "C1801950#ent", "pos": [5, 6]}}
{"token": ["Two", "C1423498#ent", "<e1>", "affected", "by", "incubation", "of", "cells", "with", "C0145745#ent", "<e2>", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0145745", "name": "C0145745#ent", "pos": [9, 10]}}
{"token": ["These", "cases", "indicate", "that", "C0028242#ent", "<e1>", "develop", "in", "patients", "with", "various", "rheumatologic", "diseases", "are", "treated", "with", "C3536709#ent", "<e2>", "and", "immunosuppressive", "drugs", "as", "cyclosporine", "."], "h": {"id": "C0028242", "name": "C0028242#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [16, 17]}}
{"token": ["Although", "there", "has", "been", "considerable", "progress", "in", "elucidating", "the", "biochemical", "functions", "C0534519#ent", "<e1>", ",", "how", "Bcl-2-related", "proteins", "caspase", "activation", "thereby", "C1418296#ent", "<e2>", ",", "has", "remained", "a", "mystery", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418296", "name": "C1418296#ent", "pos": [20, 21]}}
{"token": ["Dextromethorphan", "is", "one", "of", "the", "most", "widely", "used", "C0003449#ent", "<e1>", "for", "the", "treatment", "of", "cough", "associated", "with", "C0264222#ent", "<e2>"], "h": {"id": "C0003449", "name": "C0003449#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0264222", "name": "C0264222#ent", "pos": [17, 18]}}
{"token": ["Two", "elderly", "patients", ",", "treated", "with", "C0006938#ent", "<e1>", "for", "left", "ventricular", "dysfunction", "diabetes", ",", "developed", "severe", "C0022354#ent", "<e2>", "which", "no", "alternative", "explanation", "could", "be", "found", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [16, 17]}}
{"token": ["The", "following", "conclusions", "can", "be", "made", "from", "the", "results", "of", "this", "investigation", ":", "A", "significant", "difference", "in", "mandibular", "bone", "resorption", "associated", "with", "C0521170#ent", "<e1>", "inducing", "diet", "high", "protein", "and", "low", "in", "C2936886#ent", "<e2>", "."], "h": {"id": "C0521170", "name": "C0521170#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2936886", "name": "C2936886#ent", "pos": [31, 32]}}
{"token": ["Furthermore", ",", "the", "genetic", "basis", "familial", "juvenile", "hyperuricemic", "nephropathy", "FJHN", ")", ",", "C0431693#ent", "<e1>", "GCKD", ")", "and", "autosomal", "dominant", "C0687120#ent", "<e2>", "MCKD2", ")", "has", "been", "recently", "attributed", "to", "mutations", "within", "the", "THP", "gene", "."], "h": {"id": "C0431693", "name": "C0431693#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0687120", "name": "C0687120#ent", "pos": [19, 20]}}
{"token": ["Acute", "and", "chronic", "sodium", "depletion", "increased", "plasma", "renin", "activity", "C1419788#ent", "<e1>", ")", "and", "blunted", "the", "RVR", "to", "C1424250#ent", "<e2>", ",", "while", "acute", "sodium", "and", "chronic", "sodium", "plus", "desoxycorticosterone", "acetate", "decreased", "C1419788#ent", "<e1>", "and", "enhanced", "the", "RVR", "to", "C1424250#ent", "<e2>", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419788", "name": "C1419788#ent", "pos": [9, 10]}}
{"token": ["Angiotensin", "converting", "enzyme", "inhibition", "reduces", "blood", "levels", "C1424250#ent", "<e1>", "and", "aldosterone", ",", "but", "does", "not", "decrease", "C1419788#ent", "<e2>", "or", "AI", "and", "does", "not", "modify", "adrenal", "responsiveness", "to", "C1424250#ent", "<e1>", "in", "the", "sodium-depleted", "state", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419788", "name": "C1419788#ent", "pos": [16, 17]}}
{"token": ["The", "identification", "of", "C1333187#ent", "<e1>", "help", "to", "design", "C2717970#ent", "<e2>", "inhibitors", "."], "h": {"id": "C1333187", "name": "C1333187#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [8, 9]}}
{"token": ["By", "using", "Gal4", "fusion", "constructs", ",", "we", "identified", "an", "autonomous", "transactivation", "domain", "(", "C1705543#ent", "<e1>", ")", "at", "the", "C", "terminus", "of", "C1416499#ent", "<e2>", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416499", "name": "C1416499#ent", "pos": [21, 22]}}
{"token": ["C0013765#ent", "<e1>", "is", "the", "main", "C0017366#ent", "<e2>", "provides", "elasticity", "to", "various", "tissues", "and", "organs", "in", "vertebrates", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0017366", "name": "C0017366#ent", "pos": [5, 6]}}
{"token": ["C0013765#ent", "<e1>", "is", "a", "major", "C0017366#ent", "<e2>", "in", "large", "blood", "vessels", "lung", ",", "ligaments", ",", "and", "skin", ",", "imparting", "the", "physical", "properties", "extensibility", "and", "elastic", "recoil", "to", "these", "tissues", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0017366", "name": "C0017366#ent", "pos": [5, 6]}}
{"token": ["A", "65-year-old", "woman", ",", "treated", "with", "C0032950#ent", "<e1>", "(", "5", "mg", "daily", ")", "for", "C0038013#ent", "<e2>", "visited", "our", "hospital", "because", "of", "right", "chest", "pain"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [14, 15]}}
{"token": ["Ten-day-old", "or", "adult", "rats", "were", "pretreated", "with", "the", "C0036753#ent", "<e1>", "cyproheptadine", "(", "CYPRO", ")", ",", "or", "the", "neurotoxin", ",", "C0000543#ent", "<e2>", "(", "5,7-DHT", ")", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000543", "name": "C0000543#ent", "pos": [19, 20]}}
{"token": ["We", "deal", "with", "on", "how", "one", "can", "manage", "SNPs", "in", "C0015528#ent", "<e1>", "FXIII", ")", "and", "C0018995#ent", "<e2>", "(", "HFE", ")", "genes", "as", "molecular", "markers", "prognostic", "tools"], "h": {"id": "C0015528", "name": "C0015528#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [15, 16]}}
{"token": ["Nitric", "oxide", "NO", ")", "or", "NO-generating", "compounds", "like", "sodium", "nitroprusside", "SNP", ")", "increase", "cellular", "levels", "cGMP", "and", "produce", "S-nitrosylation", "of", "C1414968#ent", "<e1>", "GAPDH", ";", "D-glyceraldehyde-3-phosphate", ":", "NAD+", "oxidoreductase", "phosphorylating", ")", ",", "C3536868#ent", "<e2>", "."], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [20, 21]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3536868", "name": "C3536868#ent", "pos": [31, 32]}}
{"token": ["The", "reaction", "characteristics", "of", "chlorothalonil", "with", "C1414968#ent", "<e1>", "GPDH", ")", ",", "from", "yeast", ",", "(", "C3536868#ent", "<e2>", "were", "studied", "in", "vitro"], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3536868", "name": "C3536868#ent", "pos": [15, 16]}}
{"token": ["C0024814#ent", "<e1>", "MSS", ")", "is", "an", "autosomal", "recessive", "multisystem", "disorder", "by", "C0007758#ent", "<e2>", "cataracts", ",", "progressive", "muscular", "weakness", "and", "developmental", "and", "mental", "retardation"], "h": {"id": "C0024814", "name": "C0024814#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [11, 12]}}
{"token": ["Inhibition", "of", "C0044602#ent", "<e1>", "either", "wortmannin", "or", "C0251991#ent", "<e2>", "reversed", "the", "cytoprotective", "effect", "ouabain", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0251991", "name": "C0251991#ent", "pos": [7, 8]}}
{"token": ["Could", "these", "differences", "have", "increased", "the", "serum", "level", "of", "C0006949#ent", "<e1>", "and", "lead", "to", "more", "rapide", "C1427267#ent", "<e2>", "metabolism", "by", "enzymatic", "induction"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1427267", "name": "C1427267#ent", "pos": [16, 17]}}
{"token": ["They", "were", "inhibited", "by", "quinine", ",", "Gd3", "+", ",", "La3", "+", "and", "the", "C0012186#ent", "<e1>", "but", "not", "by", "the", "Ca2", "+", "or", "K+", "channel", "antagonists", "C0280858#ent", "<e2>", "and", "tetraethylammonium", "(", "TEA+", ")", "."], "h": {"id": "C0012186", "name": "C0012186#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [25, 26]}}
{"token": ["The", "recombinant", "plasmid", "pcDNA3.1BLyS", "was", "injected", "subcutaneously", "into", "BALb/C", "mice", "this", "administration", "induced", "the", "sustained", "expression", "of", "human", "C2986676#ent", "<e1>", "and", "specific", "IgG", "against", "the", "C0034861#ent", "<e2>"], "h": {"id": "C2986676", "name": "C2986676#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [25, 26]}}
{"token": ["When", "tested", "alone", ",", "an", "approximately", "49-kDa", "form", "(", "C1539847#ent", "<e1>", ")", "of", "the", "C3890353#ent", "<e2>", "bound", "weakly", "to", "kappa", "B", "but", "C1539847#ent", "<e1>", "associated", "with", "p65", "to", "bind", "efficiently", "to", "this", "site", "."], "h": {"id": "C1539847", "name": "C1539847#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3890353", "name": "C3890353#ent", "pos": [14, 15]}}
{"token": ["Adipose", "tissue", "C2939465#ent", "<e1>", "and", "ME", "activities", "decreased", "slightly", "with", "increasing", "C0077141#ent", "<e2>", "in", "starved-refed", "rats", ",", "but", "did", "not", "decrease", "in", "ad", "libitum", "rats", "."], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0077141", "name": "C0077141#ent", "pos": [11, 12]}}
{"token": ["In", "this", "work", ",", "we", "examined", "the", "expression", "and", "activity", "of", "Src", "and", "C1412131#ent", "<e1>", "C0755322#ent", "<e2>", ")", "during", "osteoblast", "differentiation", "assessed", "the", "modulation", "of", "Src", "kinase", "C0755322#ent", "<e2>", "."], "h": {"id": "C1412131", "name": "C1412131#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0755322", "name": "C0755322#ent", "pos": [15, 16]}}
{"token": ["A", "72-year-old", "man", "developed", "C0151313#ent", "<e1>", "CSN", ")", "during", "C0019189#ent", "<e2>", "HCV", ")", "infection", "."], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019189", "name": "C0019189#ent", "pos": [9, 10]}}
{"token": ["Analogous", "to", "other", "steroid", "hormones", "C0007158#ent", "<e1>", "blood", "are", "bound", "to", "a", "specific", "C3536854#ent", "<e2>", "binding", "globulin"], "h": {"id": "C0007158", "name": "C0007158#ent", "pos": [5, 6]}, "relation": "chemical_structure_of", "t": {"id": "C3536854", "name": "C3536854#ent", "pos": [13, 14]}}
{"token": ["NK", "cell", "treatment", "with", "C0631180#ent", "<e1>", "modified", "neither", "the", "surface", "expression", "of", "C1334146#ent", "<e2>", "nor", "its", "Mg2", "+", "binding", "site"], "h": {"id": "C0631180", "name": "C0631180#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334146", "name": "C1334146#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "the", "C0027051#ent", "<e1>", "survivors", "had", "higher", "C0256103#ent", "<e2>", "antigen", "levels", "at", "rest", "and", "after", "venous", "occlusion", "and", "higher", "C0256103#ent", "<e2>", "activities", "after", "venous", "occlusion"], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [9, 10]}}
{"token": ["Stimulation", "of", "human", "skin", "fibroblasts", "or", "articular", "chondrocytes", "IL-1", "or", "TNF-alpha", "in", "the", "presence", "of", "C4084754#ent", "<e1>", "resulted", "in", "a", "marked", "reduction", "of", "both", "p38", "mitogen-activated", "protein", "kinase", "C1434650#ent", "<e2>", "whereas", "nuclear", "translocation", "nuclear", "factor", "kappaB", "unimpeded", "."], "h": {"id": "C4084754", "name": "C4084754#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1434650", "name": "C1434650#ent", "pos": [28, 29]}}
{"token": ["The", "initial", "rates", "of", "the", "naphthols", "'", "and", "C0048681#ent", "<e1>", "oxidations", "were", "linearly", "dependent", "on", "C0014442#ent", "<e2>", "concentration", "."], "h": {"id": "C0048681", "name": "C0048681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "the", "Fms", "Y807F", "mutation", "decreased", "both", "binding", "and", "phosphorylation", "of", "C0250414#ent", "<e1>", "but", "not", "that", "of", "C1423078#ent", "<e2>", "."], "h": {"id": "C0250414", "name": "C0250414#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423078", "name": "C1423078#ent", "pos": [18, 19]}}
{"token": ["In", "C0006309#ent", "<e1>", "patients", "receiving", "C0733383#ent", "<e2>", "and", "placebo", "the", "dynamics", "of", "quantitative", "and", "functional", "characteristics", "of", "cell-mediated", "and", "humoral", "immunity", "been", "studied", "."], "h": {"id": "C0006309", "name": "C0006309#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0733383", "name": "C0733383#ent", "pos": [5, 6]}}
{"token": ["Besides", "methotrexate", ",", "cyclosporine", "has", "emerged", "as", "the", "drug", "of", "choice", "for", "the", "treatment", "of", "C0003872#ent", "<e1>", "since", "it", "influences", "both", "cutaneous", "and", "C0035012#ent", "<e2>", "manifestations", "of", "the", "disease", "."], "h": {"id": "C0003872", "name": "C0003872#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [23, 24]}}
{"token": ["Systemic", "associations", "include", "sarcoidosis", ",", "the", "Vogt-Harada-Koyanagi", "syndrome", "and", "the", "seronegative", "arthritides", "juvenile", "chronic", "arthritis", "juvenile", "ankylosing", "spondylitis", "C0003872#ent", "<e1>", "and", "rarely", "C0035012#ent", "<e2>", "Be\u00e7et", "'s", "syndromes", ")", "."], "h": {"id": "C0003872", "name": "C0003872#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [22, 23]}}
{"token": ["With", "excellent", "activity", "against", "C.", "trachomatis", "Neisseria", "gonorrhoeae", "prolonged", "elimination", "half-life", "allowing", "once-daily", "dosage", ",", "the", "C0949665#ent", "<e1>", "trovafloxacin", "has", "potential", "advantages", "in", "the", "treatment", "of", "uncomplicated", "C0008149#ent", "<e2>"], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008149", "name": "C0008149#ent", "pos": [27, 28]}}
{"token": ["The", "C0171406#ent", "<e1>", "a", "major", "source", "of", "reactive", "oxygen", "species", "ROS", ")", "under", "pathological", "conditions", "C0151744#ent", "<e2>", "reperfusion", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [15, 16]}}
{"token": ["For", "reasons", "that", "are", "unclear", ",", "patients", "with", "dermatitis", "herpetiformis", "C0171406#ent", "<e1>", ")", "have", "a", "lower", "than", "expected", "mortality", "rate", "C0151744#ent", "<e2>"], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [20, 21]}}
{"token": ["C0282211#ent", "<e1>", "1", "microM", "increased", "C1705516#ent", "<e2>", "activity", "in", "HUVEC", "(", "34.0+/-5.9", "%", "above", "basal", ",", "P<0.001", ")", "."], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705516", "name": "C1705516#ent", "pos": [5, 6]}}
{"token": ["Studies", "with", "specific", "inhibitors", "of", "MAPKs", "showed", "that", "p38", "MAPK", "activation", "was", "necessary", "for", "both", "IL-1", "beta", "C2001899#ent", "<e1>", "induction", ",", "but", "C1705791#ent", "<e2>", "activation", "was", "required", "only", "for", "C2001899#ent", "<e1>", "induction", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "Fcgamma", "receptor", "mediated", "immune", "complex", "trafficking", ",", "activation", "of", "MAP", "kinases", "C1705791#ent", "<e1>", "and", "p38", ")", ",", "and", "downstream", "inflammatory", "mediator", "release", "C2001899#ent", "<e2>", "and", "IL-6", ")", "were", "blocked", "by", "fluvastatin", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [25, 26]}}
{"token": ["While", "the", "C0037274#ent", "<e1>", "remained", "slight", "to", "moderate", "in", "severity", ",", "recurrent", "C0022568#ent", "<e2>", "has", "resulted", "in", "impaired", "vision", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022568", "name": "C0022568#ent", "pos": [12, 13]}}
{"token": ["Clinical", "disease", "the", "NIH", "mouse", "after", "snout", "inoculation", "includes", "C0037274#ent", "<e1>", "mydriasis", ",", "iritis", "and", "C0022568#ent", "<e2>", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022568", "name": "C0022568#ent", "pos": [15, 16]}}
{"token": ["Two", "iatrogenic", "effects", "of", "antipsychotic", "medications", "than", "C3714760#ent", "<e1>", "been", "recently", "described", "in", "schizophrenic", "populations", "C1276035#ent", "<e2>", "and", "tardive", "dysmentia", "."], "h": {"id": "C3714760", "name": "C3714760#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1276035", "name": "C1276035#ent", "pos": [15, 16]}}
{"token": ["Animals", "of", "one", "group", "ingested", "a", "normal", "diet", "with", "dihydroxyaluminum", "aminoacetate", "C0058134#ent", "<e1>", ")", ",", "15", "g%", ",", "to", "induce", "phosphate", "depletion", "C1335499#ent", "<e2>", ")", "."], "h": {"id": "C0058134", "name": "C0058134#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335499", "name": "C1335499#ent", "pos": [22, 23]}}
{"token": ["Finally", ",", "recombinant", "C1413791#ent", "<e1>", "showed", "no", "effect", "Bax", "protein", "expression", "but", "significantly", "reduced", "C0376515#ent", "<e2>", "expression", "."], "h": {"id": "C1413791", "name": "C1413791#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [14, 15]}}
{"token": ["While", "the", "prevailing", "type", "of", "C1704885#ent", "<e1>", "rearrangement", "in", "adult", "thyroid", "carcinomas", "PTC1", "involving", "C1704885#ent", "<e1>", "and", "the", "C1425774#ent", "<e1>", "the", "majority", "of", "tumors", "in", "radiation-exposed", "children", "shows", "PTC3", "."], "h": {"id": "C1704885", "name": "C1704885#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425774", "name": "C1425774#ent", "pos": [18, 19]}}
{"token": ["Plasma", "concentrations", "of", "C3273299#ent", "<e1>", "a", "CXCR3", "ligand", ",", "and", "thymus", "and", "activation-regulated", "chemokine", "C1332680#ent", "<e2>", ")", ",", "a", "CCR4", "ligand", ",", "were", "measured", "by", "enzyme-linked", "immunosorbent", "assays"], "h": {"id": "C3273299", "name": "C3273299#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332680", "name": "C1332680#ent", "pos": [14, 15]}}
{"token": ["Osmotic", "pressures", "C3273406#ent", "<e1>", ")", "of", "aqueous", "solutions", "of", "C0032478#ent", "<e2>", "PEGs", ")", "of", "average", "relative", "molecular", "weight", "M(r", ")", ")", "between", "200", "and", "10,000", "were", "measured", "using", "vapor", "pressure", "deficit", "osmometry"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032478", "name": "C0032478#ent", "pos": [9, 10]}}
{"token": ["In", "spite", "of", "its", "ability", "to", "cause", "a", "fall", "in", "BP", "via", "NK-1", "receptors", "C1824810#ent", "<e1>", "gamma", "exerted", "its", "effects", "on", "C3539667#ent", "<e2>", "and", "Cdyn", "solely", "via", "NK-2", "receptors"], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3539667", "name": "C3539667#ent", "pos": [21, 22]}}
{"token": ["Effects", "of", "pyrazole", "on", "liver", "C3254086#ent", "<e1>", "studied", "in", "two", "inbred", "strains", "mice", ",", "DBA/2N", "(", "C1414052#ent", "<e2>", ")", "and", "AKR/J", "(", "AKR", ")", "."], "h": {"id": "C3254086", "name": "C3254086#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [16, 17]}}
{"token": ["The", "inhibition", "of", "C1334895#ent", "<e1>", "degradation", "by", "a", "C1333188#ent", "<e2>", "resulted", "in", "the", "reduction", "of", "the", "apoptotic", "cells"], "h": {"id": "C1334895", "name": "C1334895#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333188", "name": "C1333188#ent", "pos": [8, 9]}}
{"token": ["PAR-AP", ",", "tc-LIGRLO-NH(2", ")", ",", "and", "C1427027#ent", "<e1>", "increased", "the", "free", "intracellular", "Ca(2+)", "concentration", ",", "whereas", "C0041236#ent", "<e2>", ",", "tryptase", ",", "thrombin", ",", "and", "other", "PAR-APs", "did", "not", "."], "h": {"id": "C1427027", "name": "C1427027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [16, 17]}}
{"token": ["C0038013#ent", "<e1>", "characterized", "by", "a", "C0017155#ent", "<e2>", "to", "destruction", "of", "connective", "tissue", "functional", "damage", "of", "cartilage", "and", "bone", "structures"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017155", "name": "C0017155#ent", "pos": [5, 6]}}
{"token": ["g", "liver-1", ")", "and", "distributions", "of", "C1417088#ent", "<e1>", "cytosolic", "phosphoenolpyruvate", "carboxykinase", "microsomal", "glucose-6-phosphatase", "studied", "in", "regenerating", "rat", "C0023899#ent", "<e2>", "after", "two", "thirds", "partial", "hepatectomy", "."], "h": {"id": "C1417088", "name": "C1417088#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [17, 18]}}
{"token": ["C1417088#ent", "<e1>", "probably", "internalized", "in", "C0023899#ent", "<e2>", ",", "spleen", "and", "bone", "marrow", "adsorptive", "endocytosis", ",", "since", "uptake", "of", "the", "enzyme", "of", "these", "tissues", "is", "saturable", "."], "h": {"id": "C1417088", "name": "C1417088#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [5, 6]}}
{"token": ["We", "assessed", "IGF-1", "and", "C0123707#ent", "<e1>", "expression", ",", "critical", "mediators", "in", "different", "models", "of", "C0034069#ent", "<e2>", "in", "nine", "Tx", "patients", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [14, 15]}}
{"token": ["C0123707#ent", "<e1>", "and", "-5", "levels", "were", "increased", "in", "vivo", "C0034069#ent", "<e2>", "lung", "tissues", "in", "vitro", "fibroblasts", "cultured", "from", "C0034069#ent", "<e2>", "lung", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [9, 10]}}
{"token": ["These", "changes", "have", "been", "the", "most", "marked", "in", "C0524911#ent", "<e1>", "the", "least", "so", "in", "chronic", "inflammatory", "diseases", "the", "intestine", ",", "in", "C0030920#ent", "<e2>", "and", "particularly", "in", "chronic", "gastritis"], "h": {"id": "C0524911", "name": "C0524911#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [21, 22]}}
{"token": ["A", "Src", "kinase", "inhibitor", "C0962522#ent", "<e1>", ",", "and", "an", "NR2B", "antagonist", ",", "C0063340#ent", "<e2>", ",", "partially", "blocked", "glutamate", "excitotoxicity", "."], "h": {"id": "C0962522", "name": "C0962522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0063340", "name": "C0063340#ent", "pos": [12, 13]}}
{"token": ["A", "library", "of", "mutations", "in", "the", "bacteriophage", "SPP1", "portal", "protein", "C1422611#ent", "<e1>", ")", "was", "generated", "by", "random", "mutagenesis", "C0017337#ent", "<e2>"], "h": {"id": "C1422611", "name": "C1422611#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["After", "ligation", "of", "any", "one", "of", "these", "receptors", ",", "Src", "family", "kinases", "activation", "of", "two", "signal", "pathways", "the", "C0089793#ent", "<e1>", "ERK2", "and", "the", "phospholipase", "Cgamma", ">", "C1705632#ent", "<e2>"], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705632", "name": "C1705632#ent", "pos": [26, 27]}}
{"token": ["A", "novel", "X-linked", "mental", "retardation", "XLMR", ")", "syndrome", "was", "recently", "identified", ",", "resulting", "from", "C0162429#ent", "<e1>", "the", "brain", "caused", "by", "mutations", "in", "the", "creatine", "transporter", "gene", "C1420219#ent", "<e2>", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420219", "name": "C1420219#ent", "pos": [26, 27]}}
{"token": ["In", "eyes", "treated", "with", "C0085387#ent", "<e1>", "period", "of", "neovascularization", "was", "slightly", "shortened", "and", "C0474441#ent", "<e2>", "decreased", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0474441", "name": "C0474441#ent", "pos": [13, 14]}}
{"token": ["Early", "reports", "the", "introduction", "of", "highly", "purified", "C3537244#ent", "<e1>", "suggested", "a", "reduction", "in", "the", "frequency", "of", "lipohypertrophy", "and", "C0023787#ent", "<e2>", "."], "h": {"id": "C3537244", "name": "C3537244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023787", "name": "C0023787#ent", "pos": [18, 19]}}
{"token": ["To", "extend", "coverage", "of", "the", "C0031686#ent", "<e1>", ",", "we", "sampled", "the", "nuclear", "extract", "HeLa", "cells", "three", "values", "of", "C1413246#ent", "<e2>", "+", "ions", "molarity", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413246", "name": "C1413246#ent", "pos": [18, 19]}}
{"token": ["Growth", "hormone", "C3539616#ent", "<e1>", ")", "is", "C0242912#ent", "<e2>", ",", "presumably", "through", "its", "actions", "on", "C3539616#ent", "<e1>", "receptor-mediated", "pathways"], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [2, 3]}}
{"token": ["To", "our", "knowledge", ",", "this", "is", "the", "1st", "reported", "case", "in", "which", "C0004259#ent", "<e1>", "effected", "immediate", "reversal", "of", "C0010073#ent", "<e2>", "hemodynamic", "decompensation", "were", "induced", "by", "exercise", ",", "rather", "than", "by", "pharmacologic", "agents"], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010073", "name": "C0010073#ent", "pos": [18, 19]}}
{"token": ["We", "previously", "reported", "the", "isolation", "of", "a", "novel", "C1517488#ent", "<e1>", "termed", "SAP", "(", "serine-", ",", "alanine-", ",", "and", "C1424869#ent", "<e2>", ",", "from", "Trypanosoma", "cruzi"], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1424869", "name": "C1424869#ent", "pos": [18, 19]}}
{"token": ["The", "immunohistochemical", "results", "demonstrated", "in", "this", "study", ",", "however", ",", "provide", "the", "first", "direct", "link", "between", "a", "morphological", "type", "C0021847#ent", "<e1>", "an", "immunohistochemical", "staining", "a", "distinct", "C0030956#ent", "<e2>", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [26, 27]}}
{"token": ["Glucose-induced", "insulin", "secretion", "24-h", "urinary", "C-peptide", "CPR", ")", "and", "euglycemic", "clamp", "examined", "in", "five", "patients", "with", "C0018213#ent", "<e1>", "and", "2", "weeks", "after", "treatment", "with", "C0104221#ent", "<e2>", "(", "20", "mg/day", ",", "p.o", ".", ")", "."], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0104221", "name": "C0104221#ent", "pos": [24, 25]}}
{"token": ["SCDM", "is", "etiologically", "heterogeneous", ",", "it", "has", "dissimilar", "etiologies", "as", "compared", "to", "C3273872#ent", "<e1>", ",", "and", "it", "is", "unlikely", "that", "C0162628#ent", "<e2>", "a", "causal", "role", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [20, 21]}}
{"token": ["The", "formation", "and", "removal", "of", "UV-induced", "pyrimidine", "dimers", "were", "measured", "in", "restriction", "fragments", "and", "within", "the", "essential", "dihydrofolate", "reductase", "C0039667#ent", "<e1>", ")", "gene", "in", "Chinese", "hamster", "ovary", "cells", "order", "to", "map", "the", "C1517495#ent", "<e2>", "DNA", "repair"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1517495", "name": "C1517495#ent", "pos": [32, 33]}}
{"token": ["These", "effects", "were", "examined", "using", "two", "commercial", "esterases", "(", "porcine", "and", "rabbit", "liver", "esterase", "and", "two", "human", "recombinant", "esterases", "C1258847#ent", "<e1>", "and", "hCE-2", ")", "as", "well", "as", "human", "recombinant", "fatty", "acid", "amide", "hydrolase", "C1427405#ent", "<e2>", ")", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1427405", "name": "C1427405#ent", "pos": [33, 34]}}
{"token": ["Both", "of", "these", "proteins", "specifically", "interacted", "with", "a", "kappa", "B-like", "binding", "site", "present", "in", "the", "IL-2R", "alpha", "promoter", "-267", "to", "-256", ")", "that", "is", "requisite", "for", "C1423716#ent", "<e1>", "expression", "of", "this", "C3273851#ent", "<e2>"], "h": {"id": "C1423716", "name": "C1423716#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3273851", "name": "C3273851#ent", "pos": [31, 32]}}
{"token": ["Recent", "case", "reports", "the", "successful", "treatment", "of", "granuloma", "annulare", "C1418845#ent", "<e1>", "antagonists", "or", "C0165032#ent", "<e2>", "and", "with", "the", "systemic", "administration", "biologicals", "."], "h": {"id": "C1418845", "name": "C1418845#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0165032", "name": "C0165032#ent", "pos": [13, 14]}}
{"token": ["Treatment", "groups", "one", "of", "the", "following", "anthelmintics", ":", "mebendazole", ",", "febantel", ",", "febantel", "plus", "trichlorphon", ",", "C0026535#ent", "<e1>", "or", "a", "combination", "of", "C0039832#ent", "<e2>", ",", "piperazine", "and", "trichlorphon", "."], "h": {"id": "C0026535", "name": "C0026535#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0039832", "name": "C0039832#ent", "pos": [22, 23]}}
{"token": ["The", "preferred", "treatment", "for", "C0005716#ent", "<e1>", "in", "less", "severe", "cases", "is", "C0064113#ent", "<e2>", "with", "amphotericin", "B", "disseminated", "cases", "."], "h": {"id": "C0005716", "name": "C0005716#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [11, 12]}}
{"token": ["We", "considered", "that", "C1332089#ent", "<e1>", "might", "be", "important", "in", "C0242706#ent", "<e2>", "acute", "lung", "injury", "ALI", ")", "."], "h": {"id": "C1332089", "name": "C1332089#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242706", "name": "C0242706#ent", "pos": [9, 10]}}
{"token": ["We", "previously", "demonstrated", "that", "the", "lectin", "Ulex", "europaeus", "agglutinin", "1", "(", "UEA1", ",", "specific", "for", "C0016787#ent", "<e1>", "selectively", "binds", "to", "mouse", "Peyer's", "patch", "M", "cells", "targets", "0.5", "microm", "C0142915#ent", "<e2>", "microparticles", "to", "these", "cells", "."], "h": {"id": "C0016787", "name": "C0016787#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0142915", "name": "C0142915#ent", "pos": [28, 29]}}
{"token": ["In", "the", "case", "of", "C1861922#ent", "<e1>", "marked", "hypertrophic", "change", "of", "the", "cambium", "layer", "the", "C0151846#ent", "<e2>", "at", "the", "concave", "side", "of", "the", "bone", "was", "noted", "."], "h": {"id": "C1861922", "name": "C1861922#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0151846", "name": "C0151846#ent", "pos": [14, 15]}}
{"token": ["The", "importance", "of", "C1335858#ent", "<e1>", "regulate", "maximal", "C1335237#ent", "<e2>", "promoter", "activity", "further", "established", "by", "EMSAs", "and", "cotransfection", "experiments", "in", "Sp1-null", "Drosophila", "SL2", "cells", "."], "h": {"id": "C1335858", "name": "C1335858#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335237", "name": "C1335237#ent", "pos": [7, 8]}}
{"token": ["Western", "assays", "developed", "and", "changes", "in", "C0961737#ent", "<e1>", "tenderization", "level", "and", "desmin", "were", "determined", "in", "Longissimui", "(", "C1836777#ent", "<e2>", ")", "during", "post-mortem", "storage"], "h": {"id": "C0961737", "name": "C0961737#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1836777", "name": "C1836777#ent", "pos": [17, 18]}}
{"token": ["It", "has", "been", "found", "that", "Jade-1L/2/3", "proteins", "co-purify", "with", "a", "novel", "C0062773#ent", "<e1>", "complex", ",", "consisting", "of", "HBO1", ",", "ING4/5", ",", "and", "C3811109#ent", "<e2>", "."], "h": {"id": "C0062773", "name": "C0062773#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3811109", "name": "C3811109#ent", "pos": [22, 23]}}
{"token": ["Serum-", "and", "C1528301#ent", "<e1>", "SGK", ")", "is", "a", "C0031727#ent", "<e2>", "has", "a", "catalytic", "domain", "to", "that", "of", "Akt", ",", "but", "lacks", "the", "pleckstrin", "homology", "domain", "in", "Akt", "."], "h": {"id": "C1528301", "name": "C1528301#ent", "pos": [2, 3]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}}
{"token": ["The", "ocular", "absorption", "C0006388#ent", "<e1>", "in", "the", "presence", "of", "C0770456#ent", "<e2>", "at", "acidic", "pH", "enhanced", "by", "the", "use", "of", "sulfosuccinates", ",", "specifically", "Schercopol", "CMS", "."], "h": {"id": "C0006388", "name": "C0006388#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0770456", "name": "C0770456#ent", "pos": [9, 10]}}
{"token": ["These", "effects", "are", "blocked", "by", "C0031441#ent", "<e1>", "but", "not", "by", "C0087093#ent", "<e2>", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0087093", "name": "C0087093#ent", "pos": [10, 11]}}
{"token": ["C1333949#ent", "<e1>", "free", "of", "C0012920#ent", "<e2>", "DNA", "ligase", "nuclease", "activities"], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012920", "name": "C0012920#ent", "pos": [4, 5]}}
{"token": ["In", "such", "patients", ",", "impaired", "glucose", "tolerance", "C0020456#ent", "<e1>", ",", "relative", "insulin", "resistance", "peripheral", "neuropathy", "and", "a", "C0006112#ent", "<e2>", "been", "noted", "with", "reversal", "of", "the", "clinical", "phenomena", "Cr", "repletion", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006112", "name": "C0006112#ent", "pos": [17, 18]}}
{"token": ["This", "second", "step", "involves", "C0012906#ent", "<e1>", "treatment", "that", "eliminates", "the", "plasmids", "containing", "an", "C3715179#ent", "<e2>", "in", "the", "wrong", "orientation", "prior", "to", "transformation", "into", "the", "bacterial", "host", "for", "further", "protein", "expression", "studies", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3715179", "name": "C3715179#ent", "pos": [13, 14]}}
{"token": ["The", "upregulation", "of", "AKR1C", "enzymes", ",", "induced", "by", "chemically", "homogeneous", "panaxytriol", ",", "was", "partially", "dependent", "on", "PKC", "and", "C1705590#ent", "<e1>", "demonstrated", "by", "the", "application", "of", "C0003015#ent", "<e2>"], "h": {"id": "C1705590", "name": "C1705590#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [25, 26]}}
{"token": ["However", ",", "2,5-anhydro-D-mannitol", "(", "a", "fused", "furanose", "ring", "analogue", "C0172870#ent", "<e1>", ")", "inhibited", "both", "6-deoxy-D-glucose", "and", "C0172870#ent", "<e1>", "a", "Ki", "of", "approx", "."], "h": {"id": "C0172870", "name": "C0172870#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0172870", "name": "C0172870#ent", "pos": [9, 10]}}
{"token": ["After", "separation", "of", "rabbit", "jejunal", "mRNA", "on", "a", "sucrose", "density", "gradient", ",", "the", "fractions", "that", "conferred", "C0172870#ent", "<e1>", "in", "oocytes", "also", "hybridized", "with", "rabbit", "C0172870#ent", "<e1>", "cDNA", "."], "h": {"id": "C0172870", "name": "C0172870#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0172870", "name": "C0172870#ent", "pos": [16, 17]}}
{"token": ["C0079423#ent", "<e1>", "also", "blocked", "C0729218#ent", "<e2>", "but", "not", "CsA-mediated", "inhibition", "of", "IL-2", "mRNA", "induction", "."], "h": {"id": "C0079423", "name": "C0079423#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0729218", "name": "C0729218#ent", "pos": [4, 5]}}
{"token": ["The", "hepatotoxicity", "of", "C2917659#ent", "<e1>", "(", "APAP", ")", "and", "carbon", "tetrachloride", "C3887559#ent", "<e2>", ")", "on", "the", "rat", "liver", "cells", "also", "decreased", "by", "the", "leaf", "infusion", "."], "h": {"id": "C2917659", "name": "C2917659#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887559", "name": "C3887559#ent", "pos": [11, 12]}}
{"token": ["Available", "data", "measuring", "synovial", "tissue", "concentrations", "of", "three", "C0003211#ent", "<e1>", "demonstrates", "higher", "levels", "of", "C0069739#ent", "<e2>", "in", "comparison", "to", "piroxicam", "and", "naproxen", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [8, 9]}, "relation": "structural_class_of", "t": {"id": "C0069739", "name": "C0069739#ent", "pos": [14, 15]}}
{"token": ["Excitable", "cells", "express", "multiple", "alpha", "subtypes", ",", "designated", "C3538758#ent", "<e1>", ",", "and", "three", "beta", "subunits", "designated", "beta1", ",", "beta2", "and", "C2698300#ent", "<e2>", "."], "h": {"id": "C3538758", "name": "C3538758#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2698300", "name": "C2698300#ent", "pos": [20, 21]}}
{"token": ["Similarly", ",", "the", "combination", "of", "loratadine", "20", "mg", "and", "the", "leukotriene-receptor", "antagonist", "C0298130#ent", "<e1>", "improved", "asthma", "symptoms", ",", "peak", "expiratory", "flow", "and", "C0001644#ent", "<e2>", "use", "over", "C0298130#ent", "<e1>", "alone", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0298130", "name": "C0298130#ent", "pos": [12, 13]}}
{"token": ["C0075193#ent", "<e1>", "might", "be", "considered", "as", "a", "C0597058#ent", "<e2>", "view", "of", "its", "ability", "to", "induce", "neurite", "outgrowth", "to", "increase", "tau", "protein", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597058", "name": "C0597058#ent", "pos": [7, 8]}}
{"token": ["We", "have", "recently", "discovered", "an", "alternative", "function", "of", "the", "C0949706#ent", "<e1>", "Nm23", ",", "which", "is", "identical", "to", "nucleoside", "diphosphate", "kinase", "as", "a", "C1335408#ent", "<e2>", "in", "vitro"], "h": {"id": "C0949706", "name": "C0949706#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335408", "name": "C1335408#ent", "pos": [22, 23]}}
{"token": ["Since", "the", "microparticle", "shedding", "is", "a", "calpain-activation", "dependent", "step", ",", "we", "assessed", "C1413109#ent", "<e1>", "activation", "by", "analysis", "of", "autoproteolysis", "in", "shorter", "active", "forms", "by", "C1420760#ent", "<e2>", "proteolysis", "in", "the", "presence", "of", "TSs", "."], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420760", "name": "C1420760#ent", "pos": [24, 25]}}
{"token": ["C3d", "levels", "were", "raised", "during", "C0019345#ent", "<e1>", "not", "during", "C1705457#ent", "<e2>", "."], "h": {"id": "C0019345", "name": "C0019345#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705457", "name": "C1705457#ent", "pos": [9, 10]}}
{"token": ["Mutation", "of", "PTEN-induced", "kinase", "1", "(", "PINK1", ")", ",", "which", "encodes", "a", "putative", "mitochondrial", "serine/threonine", "kinase", "leads", "to", "C1853833#ent", "<e1>", ",", "an", "autosomal", "C0017361#ent", "<e2>", "familial", "Parkinson's", "disease"], "h": {"id": "C1853833", "name": "C1853833#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [23, 24]}}
{"token": ["The", "rank", "of", "order", "of", "similarity", "to", "heart", "FABP", "is", ":", "422", "greater", "than", "myelin", "P2", "than", "cellular", "retinoic", "acid-binding", "protein", "than", "C1419317#ent", "<e1>", "than", "cellular", "retinol-binding", "protein", "than", "intestinal", "C1333528#ent", "<e2>", "greater", "than", "liver", "FABP", "."], "h": {"id": "C1419317", "name": "C1419317#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1333528", "name": "C1333528#ent", "pos": [30, 31]}}
{"token": ["In", "Group", "I", "C1539327#ent", "<e1>", "was", "induced", "with", "C0025384#ent", "<e2>", "+", "adrenaline", "1:200,000", "(", "n", "=", "20", ")", "and", "in", "Group", "II", "mepivacaine", "2", "was", "used", "(", "n", "=", "20", ")", "."], "h": {"id": "C1539327", "name": "C1539327#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025384", "name": "C0025384#ent", "pos": [8, 9]}}
{"token": ["The", "5'-flanking", "region", "the", "PACAP", "gene", "contains", "several", "sequence", "motifs", "homologous", "to", "C1511573#ent", "<e1>", ",", "TRE", ",", "and", "C1418759#ent", "<e2>", "."], "h": {"id": "C1511573", "name": "C1511573#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418759", "name": "C1418759#ent", "pos": [18, 19]}}
{"token": ["We", "here", "describe", "elevated", "serum", "levels", "of", "C1334119#ent", "<e1>", "in", "MS", ",", "GBS", "and", "C0024796#ent", "<e2>", "for", "the", "first", "time", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [14, 15]}}
{"token": ["There", "was", "no", "significant", "difference", "in", "sensitivity", "to", "C0600370#ent", "<e1>", ",", "but", "the", "maximal", "response", "to", "C0600370#ent", "<e1>", "was", "significantly", "greater", "in", "the", "C0006931#ent", "<e1>", "rats", "."], "h": {"id": "C0600370", "name": "C0600370#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [23, 24]}}
{"token": ["We", "evaluated", "the", "potency", "of", "C0022245#ent", "<e1>", ",", "carbachol", ",", "pilocarpine", "and", "calcitonin", "gene-related", "peptide", "C1705783#ent", "<e2>", ")", "in", "the", "rat", "right", "atria", "30", ",", "60", "and", "90", "days", "after", "neonatal", "capsaicin", "treatment", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705783", "name": "C1705783#ent", "pos": [15, 16]}}
{"token": ["Impaired", "remyelination", "due", "to", "degeneration", "of", "both", "postmitotic", "oligodendrocytes", "and", "oligodendrocyte", "progenitors", "C1416917#ent", "<e1>", ")", "is", "the", "major", "hallmark", "of", "inflammatory", "demyelination", "C1417325#ent", "<e2>", "MS", ")", "lesions", "and", "experimental", "autoimmune", "encephalomyelitis", "EAE", ")", "."], "h": {"id": "C1416917", "name": "C1416917#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [22, 23]}}
{"token": ["Alteration", "of", "the", "length", "of", "this", "region", "leaving", "the", "actin", "binding", "site", "intact", "results", "in", "altered", "actin-activated", "MgATPase", "kinetics", "when", "these", "C0238239#ent", "<e1>", "hybridised", "into", "C0027112#ent", "<e2>"], "h": {"id": "C0238239", "name": "C0238239#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0027112", "name": "C0027112#ent", "pos": [25, 26]}}
{"token": ["In", "vitro", "studies", "indicate", "that", "C2825106#ent", "<e1>", "is", "an", "C0021699#ent", "<e2>", "and", "immunolocalization", "experiments", "using", "epitope-tagged", "C2825106#ent", "<e1>", "demonstrate", "that", "the", "protein", "is", "localized", "to", "the", "Golgi", "apparatus"], "h": {"id": "C2825106", "name": "C2825106#ent", "pos": [5, 6]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [9, 10]}}
{"token": ["Importantly", ",", "the", "extent", "of", "C2827368#ent", "<e1>", "expression", "corresponds", "roughly", "to", "sperm", "number", "C2987364#ent", "<e2>", "and", "mutants", ",", "altering", "sperm", "number"], "h": {"id": "C2827368", "name": "C2827368#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}}
{"token": ["Besides", "the", "C0029166#ent", "<e1>", "leptospirosis", "may", "rarely", "occur", "with", "C0542035#ent", "<e2>", "pancytopenia", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0542035", "name": "C0542035#ent", "pos": [9, 10]}}
{"token": ["We", "show", "in", "this", "paper", "that", "Ca(2+)-calmodulin", "inhibits", "phospholipid-stimulated", "autophosphorylation", "C0207694#ent", "<e1>", "hence", "also", "inhibits", "the", "catalytic", "activity", "C0031713#ent", "<e2>", "the", "presence", "of", "phospholipid", "."], "h": {"id": "C0207694", "name": "C0207694#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031713", "name": "C0031713#ent", "pos": [18, 19]}}
{"token": ["Aberrations", "in", "C0169658#ent", "<e1>", ",", "that", "may", "lead", "to", "C0221423#ent", "<e2>", "of", "one", "or", "more", "of", "the", "above", "mentioned", "pathways", "could", "disrupt", "normal", "cellular", "responses", "result", "in", "disease", "states"], "h": {"id": "C0169658", "name": "C0169658#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [9, 10]}}
{"token": ["Our", "results", "showed", "that", "C1518781#ent", "<e1>", ",", "a", "potent", "EGF", "receptor", "inhibitor", "blocked", "UV-induced", "C1333655#ent", "<e2>", "expression", "."], "h": {"id": "C1518781", "name": "C1518781#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333655", "name": "C1333655#ent", "pos": [14, 15]}}
{"token": ["Cloning", "of", "the", "human", "C0755322#ent", "<e1>", "that", "two", "isoforms", "exist", ",", "termed", "C2981736#ent", "<e2>", "HAAP", "beta", "(", "human", "C0755322#ent", "<e1>", ",", "which", "are", "distinguished", "by", "a", "34-amino", "acid", "isoform-specific", "domain", "."], "h": {"id": "C0755322", "name": "C0755322#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2981736", "name": "C2981736#ent", "pos": [12, 13]}}
{"token": ["Also", "grade", "III", "IV", "infections", "P=0.008", ")", ",", "C2926735#ent", "<e1>", "of", "antibiotic", "therapy", "P=0.03", ")", "and", "C2926735#ent", "<e1>", "of", "fever", "(", "P=0.04", ")", "were", "significantly", "reduced", "with", "C3537278#ent", "<e1>", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3537278", "name": "C3537278#ent", "pos": [27, 28]}}
{"token": ["On", "the", "basis", "of", "previous", "studies", ",", "we", "postulated", "that", "C1705340#ent", "<e1>", "regulates", "sodium", "pump", "activity", "through", "Src", "kinase", "C0031669#ent", "<e2>", ",", "and", "calcium-dependent", "ERK", "phosphorylation", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [19, 20]}}
{"token": ["Impairment", "of", "C1705340#ent", "<e1>", "activation", "of", "both", "C0031669#ent", "<e2>", "isoforms", "upon", "ageing", "may", "result", "in", "abnormal", "hormone", "regulation", "cell", "Ca(2", "+", ")", "and", "proliferation", "in", "the", "duodenum", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [7, 8]}}
{"token": ["In", "eukaryotic", "cells", "TATA-binding", "protein", "TBP", ")", "associates", "with", "other", "proteins", "known", "as", "TBP-associated", "factors", "C0795907#ent", "<e1>", ")", "to", "form", "multisubunit", "transcription", "factors", "for", "gene", "expression", "all", "three", "C0035542#ent", "<e2>"], "h": {"id": "C0795907", "name": "C0795907#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [28, 29]}}
{"token": ["Atypical", "(", ")", "C0019061#ent", "<e1>", "a", "heterogeneous", "yet", "distinct", "subgroup", "of", "C0019061#ent", "<e1>", "differs", "from", "C2931788#ent", "<e1>", "epidemiologic", ",", "clinical", ",", "laboratory", ",", "histologic", ",", "and", "prognostic", "grounds", "."], "h": {"id": "C0019061", "name": "C0019061#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C2931788", "name": "C2931788#ent", "pos": [15, 16]}}
{"token": ["A", "case", "of", "C3661448#ent", "<e1>", "an", "overdose", "of", "C0029310#ent", "<e2>", "Norflex", ")", ",", "treated", "with", "tetrahydroaminacrine", "(", "THA", ",", "Tacrine", ")", "is", "presented", "."], "h": {"id": "C3661448", "name": "C3661448#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029310", "name": "C0029310#ent", "pos": [8, 9]}}
{"token": ["Long-term", "surveillance", "of", "the", "extant", "34", "patients", "showed", "that", "8", ",", "all", "of", "whom", "had", "C0017668#ent", "<e1>", ",", "evolved", "to", "end-stage", "renal", "failure", "to", "progression", "of", "their", "C0022658#ent", "<e2>", "ending", "CsA", "treatment", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [27, 28]}}
{"token": ["A", "superfamily", "of", "C3816480#ent", "<e1>", "GDP", "release", "from", "heterotrimeric", "guanine", "nucleotide-binding", "proteins", "C0086376#ent", "<e2>", "to", "initiate", "the", "intracellular", "signaling", "cascade"], "h": {"id": "C3816480", "name": "C3816480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["Some", "C0013036#ent", "<e1>", "known", "to", "inhibit", "C0013136#ent", "<e2>", "binding", "in", "corpus", "striatum", "also", "inhibited", "the", "same", "in", "rat", "and", "human", "blood", "platelet", "membranes", "in", "vitro", "."], "h": {"id": "C0013036", "name": "C0013036#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013136", "name": "C0013136#ent", "pos": [6, 7]}}
{"token": ["Finally", ",", "a", "significant", "expression", "of", "c-Met", "in", "C3273435#ent", "<e1>", "membranes", "were", "observed", "in", "both", "diabetic", "patients", "with", "C0154830#ent", "<e2>", "and", "in", "non-diabetic", "subjects", "."], "h": {"id": "C3273435", "name": "C3273435#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0154830", "name": "C0154830#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "the", "effect", "of", "timolol", ",", "another", "C0304516#ent", "<e1>", "on", "reducing", "C1167662#ent", "<e2>", "was", "compared", "with", "that", "of", "propranolol", "."], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1167662", "name": "C1167662#ent", "pos": [12, 13]}}
{"token": ["Adverse", "effects", "C0003873#ent", "<e1>", "patients", "receiving", "C0063041#ent", "<e2>", "included", "diarrhea", ",", "elevated", "liver", "enzymes", "alopecia", ",", "and", "rash", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0063041", "name": "C0063041#ent", "pos": [6, 7]}}
{"token": ["Gastric", "bypass", "C3538683#ent", "<e1>", ";", "227", "cases", ")", "was", "compared", "with", "gastroplasty", "(", "C3811116#ent", "<e2>", ";", "189", "cases", ")", "with", "a", "follow-up", "of", "six", "months", "to", "four", "years", "."], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3811116", "name": "C3811116#ent", "pos": [13, 14]}}
{"token": ["The", "fruit", "juice", "C1328724#ent", "<e1>", "noni", ")", "contains", "a", "C0032594#ent", "<e2>", "noni-ppt", ")", "with", "antitumour", "activity", "in", "the", "Lewis", "lung", "LLC", ")", "peritoneal", "carcinomatosis", "model", "."], "h": {"id": "C1328724", "name": "C1328724#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [9, 10]}}
{"token": ["Both", "levels", "of", "C1707122#ent", "<e1>", "with", "verapamil", "also", "increased", "IVCT", "more", "than", "did", "C0720810#ent", "<e2>", "or", "ISO", "with", "verapamil.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1707122", "name": "C1707122#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0720810", "name": "C0720810#ent", "pos": [13, 14]}}
{"token": ["No", "clinically", "or", "statistically", "significant", "in", "C0040377#ent", "<e1>", "kinetics", "between", "normal", "volunteers", "C0003873#ent", "<e2>", "patients", "were", "found", "."], "h": {"id": "C0040377", "name": "C0040377#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [12, 13]}}
{"token": ["Fish", "oil", "increases", "C0536847#ent", "<e1>", "expression", "in", "hepatocytes", "and", "may", "enhance", "C0536847#ent", "<e1>", "activity", "by", "activating", "the", "UCP2", "molecule", "or", "C2712370#ent", "<e1>", "the", "lipid", "bilayer", "environment"], "h": {"id": "C0536847", "name": "C0536847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [20, 21]}}
{"token": ["C0155241#ent", "<e1>", "may", "arise", "in", "the", "setting", "of", "C0038325#ent", "<e2>"], "h": {"id": "C0155241", "name": "C0155241#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038325", "name": "C0038325#ent", "pos": [8, 9]}}
{"token": ["Glucogenic", "amylase", "activities", "and", "beta-galactosidase", "were", "produced", "constitutively", ",", "whereas", "the", "synthesis", "of", "C0119421#ent", "<e1>", "induced", "by", "either", "xylose", "or", "C0059100#ent", "<e2>", "."], "h": {"id": "C0119421", "name": "C0119421#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0059100", "name": "C0059100#ent", "pos": [20, 21]}}
{"token": ["Associated", "with", "fevers", "are", "aphthous", "stomatitis", "70", "%", "of", "patients", ",", "C0001344#ent", "<e1>", "in", "72", "%", "of", "patients", ",", "and", "C0149642#ent", "<e2>", "88", "%", "of", "patients", "."], "h": {"id": "C0001344", "name": "C0001344#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0149642", "name": "C0149642#ent", "pos": [20, 21]}}
{"token": ["C1541519#ent", "<e1>", "is", "an", "oncolytic", "adenovirus", "which", "tumor-specific", "promoters", "driving", "the", "expression", "of", "C1709313#ent", "<e2>", "and", "E1B", "proteins", "."], "h": {"id": "C1541519", "name": "C1541519#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [13, 14]}}
{"token": ["Familial", "susceptibility", "MS", ",", "autoimmune", "diseases", "C0149931#ent", "<e1>", ",", "and", "vaccination", "to", "C0025007#ent", "<e2>", "are", "associated", "with", "increased", "risk", "of", "MS", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025007", "name": "C0025007#ent", "pos": [12, 13]}}
{"token": ["Training", "alone", "produced", "increases", "in", "the", "percentage", "of", "fast", "twitch", "high", "oxidative", "fibres", "(", "C1414833#ent", "<e1>", ")", ",", "glycogen", "content", "and", "the", "activities", "of", "citrate", "synthase", "C0000404#ent", "<e2>", "cytochrome", "oxidase"], "h": {"id": "C1414833", "name": "C1414833#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0000404", "name": "C0000404#ent", "pos": [26, 27]}}
{"token": ["We", "have", "previously", "demonstrated", "that", "intravenous", "injections", "of", "C2697656#ent", "<e1>", "increased", "the", "NO", "precursor", "L-arginine-induced", "depressor", "effect", "the", "C1417869#ent", "<e2>", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [18, 19]}}
{"token": ["Cannabinoid", "receptor", "2", "C1413555#ent", "<e1>", ")", "agonists", "provide", "the", "potential", "for", "treating", "C0150055#ent", "<e2>", "CNS", "effects", "associated", "with", "CB1", "receptor", "activation", "."], "h": {"id": "C1413555", "name": "C1413555#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0150055", "name": "C0150055#ent", "pos": [12, 13]}}
{"token": ["The", "C0162757#ent", "<e1>", "methysergide", ",", "administered", "into", "the", "periaqueductal", "gray", "matter", "C1705981#ent", "<e2>", ")", ",", "inhibited", "the", "antinociceptive", "effect", "of", "morphine", ",", "but", "not", "of", "glutamate", ",", "also", "administered", "into", "the", "C1705981#ent", "<e2>", "."], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705981", "name": "C1705981#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "MEHP", "also", "inhibited", "FSH-stimulated", "C2757070#ent", "<e1>", "production", ",", "a", "C0010531#ent", "<e2>", "process", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}}
{"token": ["In", "mice", "that", "received", "estradiol", "plus", "C2757070#ent", "<e1>", ",", "treatment", "with", "hydrocortisone", "plus", "prolactin", "decreased", "bovine", "mammary", "tissue", "cyclic", "3',5'-adenosine", "monophosphate", "C0010531#ent", "<e2>", "increased", "tissue", "cyclic", "3',5'-guanosine", "monophosphate-dependent", "protein", "kinase"], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [21, 22]}}
{"token": ["The", "results", "establish", "association", "and", "biological", "activity", "the", "bacterially", "produced", "C0599220#ent", "<e1>", "and", "provide", "a", "system", "for", "studying", "structure-function", "relationships", "in", "C0006784#ent", "<e2>", "by", "means", "of", "mutagenesis", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [21, 22]}}
{"token": ["C0206461#ent", "<e1>", "Fragmin", ",", "Pharmacia", "Corporation", ")", "is", "a", "low", "molecular", "weight", "heparin", "C0019139#ent", "<e2>", ")", "with", "a", "mean", "molecular", "weight", "approximately", "5000", "Da", "."], "h": {"id": "C0206461", "name": "C0206461#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "the", "expression", "of", "NCSTN-DeltaE16", "transcript", "may", "confer", "some", "additional", "risk", "for", "developing", "C0002395#ent", "<e1>", "the", "risk", "due", "to", "C3642141#ent", "<e2>"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [15, 16]}, "relation": "disease_has_associated_gene", "t": {"id": "C3642141", "name": "C3642141#ent", "pos": [21, 22]}}
{"token": ["In", "the", "C1412056#ent", "<e1>", "vector", ",", "pTS1", ",", "the", "C1366498#ent", "<e2>", "expressed", "under", "the", "control", "of", "the", "major", "C1412056#ent", "<e1>", "promoter", "p40", "."], "h": {"id": "C1366498", "name": "C1366498#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412056", "name": "C1412056#ent", "pos": [2, 3]}}
{"token": ["Tuberculosis", ",", "C0025229#ent", "<e1>", ",", "and", "leprosy", "are", "the", "major", "C0149516#ent", "<e2>", "bacterial", "origin"], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0149516", "name": "C0149516#ent", "pos": [10, 11]}}
{"token": ["A", "possible", "role", "of", "TH", "in", "the", "fat", "body", "bacteria-challenged", "larvae", "would", "be", "to", "supply", "catecholamines", "as", "the", "substrate", "for", "C0041484#ent", "<e1>", "leading", "to", "melanization", ",", "working", "together", "with", "C0003806#ent", "<e2>"], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003806", "name": "C0003806#ent", "pos": [29, 30]}}
{"token": ["C0066282#ent", "<e1>", "widely", "available", "as", "a", "component", "in", "many", "C0013231#ent", "<e2>", "creams", ",", "ointments", ",", "lotions", ",", "liniments", "and", "medicated", "oils", "intended", "for", "topical", "application", "to", "relieve", "musculoskeletal", "aches", "pains", "."], "h": {"id": "C0066282", "name": "C0066282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013231", "name": "C0013231#ent", "pos": [9, 10]}}
{"token": ["We", "selected", "five", "candidate", "T3", "target", "genes", ",", "neurexophilin", "2", "C1424300#ent", "<e1>", "SPNR", ")", ",", "kallikrein-binding", "protein", "KBP", ")", ",", "C1310550#ent", "<e2>", "PSMA", ")", ",", "and", "synaptotagmin", "II", "for", "more", "detailed", "study", "."], "h": {"id": "C1424300", "name": "C1424300#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1310550", "name": "C1310550#ent", "pos": [20, 21]}}
{"token": ["We", "report", "on", "a", "patient", "with", "primary", "adrenocortical", "insufficiency", "initially", "presenting", "with", "C0086132#ent", "<e1>", "who", "developed", "C0001889#ent", "<e2>", "by", "acute", "manic", "illness", "after", "the", "initiation", "of", "steroid", "replacement"], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001889", "name": "C0001889#ent", "pos": [16, 17]}}
{"token": ["We", "hypothesized", "that", "some", "transcription", "factor(s", ")", "may", "cooperate", "with", "p53", "in", "regulating", "the", "C1333655#ent", "<e1>", "gene", "early", "after", "the", "irradiation", "of", "C1705556#ent", "<e2>"], "h": {"id": "C1333655", "name": "C1333655#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [22, 23]}}
{"token": ["One", "patient", "developed", "severe", "hyponatremia", "with", "serum", "Na+", "108", "mEq/L", "when", "C0020261#ent", "<e1>", "was", "given", "to", "C0020538#ent", "<e2>"], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}}
{"token": ["C0376637#ent", "<e1>", ",", "which", "also", "was", "metabolized", "predominantly", "by", "C3814396#ent", "<e2>", "enzymes", ",", "extensively", "inhibited", "compound", "A", "metabolism", "in", "microsomes", ",", "whereas", "compound", "A", "weak", "inhibitory", "potency", "on", "indinavir", "metabolism", "."], "h": {"id": "C0376637", "name": "C0376637#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3814396", "name": "C3814396#ent", "pos": [9, 10]}}
{"token": ["A", "case", "of", "agranulocytosis", "during", "C0024530#ent", "<e1>", "prophylaxis", "with", "Maloprim", "(", "pyrimethamine", "and", "C0010980#ent", "<e2>", ")", "is", "described", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [13, 14]}}
{"token": ["This", "has", "been", "proved", "by", "the", "efficacy", "of", "some", "C0242911#ent", "<e1>", "are", "known", "to", "act", "via", "generation", "of", "C0812281#ent", "<e2>", "when", "administered", "clinically", "or", "experimentally", "."], "h": {"id": "C0242911", "name": "C0242911#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [18, 19]}}
{"token": ["The", "adenovirus", "early", "gene", "product", "C1335808#ent", "<e1>", "is", "crucial", "for", "virus", "replication", "induces", "certain", "cellular", "genes", "inactivating", "histone", "deacetylase", "1", "C1334032#ent", "<e2>", ")", "."], "h": {"id": "C1335808", "name": "C1335808#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "the", "cleavage", "of", "endogenous", "C3811165#ent", "<e1>", "is", "independent", "of", "the", "proteasome", "as", "treatment", "with", "the", "C3537238#ent", "<e2>", "lactacystin", "did", "not", "inhibit", "cleavage", "."], "h": {"id": "C3811165", "name": "C3811165#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537238", "name": "C3537238#ent", "pos": [18, 19]}}
{"token": ["Whereas", "antithrombin", "and", "C0893651#ent", "<e1>", "failed", "to", "improve", "clinical", "outcome", "cases", "of", "severe", "sepsis", ",", "C1170000#ent", "<e2>", "activated", ")", "increased", "the", "chances", "of", "survival", "of", "patients", "with", "this", "condition", "."], "h": {"id": "C0893651", "name": "C0893651#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1170000", "name": "C1170000#ent", "pos": [15, 16]}}
{"token": ["The", "C0032594#ent", "<e1>", "which", "is", "C3889446#ent", "<e2>", "on", "numerous", "cancer", "cell", "surfaces", ",", "was", "selected", "as", "the", "model", "antigen", "for", "our", "study", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [5, 6]}}
{"token": ["The", "documentation", "of", "the", "effect", "of", "milk", "fever", "the", "downer", "cows", ",", "C0178829#ent", "<e1>", "occurrence", "of", "other", "C0012634#ent", "<e2>", "and", "the", "effect", "on", "milk", "production", ",", "body", "weight", "culling", "."], "h": {"id": "C0178829", "name": "C0178829#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [17, 18]}}
{"token": ["Activation", "of", "the", "C0246976#ent", "<e1>", "downstream", "phosphorylation", "of", "p38", "MAPK", "phospholipase", "C", "and", "C0089793#ent", "<e2>", "signaling", "pathways", "regulate", "Fc-receptor-mediated", "degranulation", "of", "chicken", "heterophils"], "h": {"id": "C0246976", "name": "C0246976#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [13, 14]}}
{"token": ["Annexin-1", "stimulation", "of", "C2001899#ent", "<e1>", "secretion", "was", "inhibited", "by", "both", "a", "formyl", "peptide", "receptor", "antagonist", "C0043167#ent", "<e2>", "suggesting", "that", "secreted", "annexin-1", "acts", "via", "formyl", "peptide", "family", "receptors", "most", "likely", "FPLR-1", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [15, 16]}}
{"token": ["These", "included", "the", "nuclear", "dihydrofolate", "reductase", "gene", "a", "C1333187#ent", "<e1>", "mitochondrial", "cytochrome", "b", "cytochrome", "oxidase", "I", "genes", "and", "the", "C0059036#ent", "<e2>", "caseinolytic", "protease", "C", ",", "and", "\"", "open", "reading", "frame", "470", "genes", "from", "the", "apicoplast", "genome", "for", "a", "combined", "total", "of", "5049", "nucleotides", "."], "h": {"id": "C1333187", "name": "C1333187#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [19, 20]}}
{"token": ["Ophthalmoscopically", ",", "the", "patient's", "sister", "only", "fine", "pigment", "migrations", "at", "the", "C0332573#ent", "<e1>", ",", "whereas", "local", "C0599295#ent", "<e2>", "revealed", "a", "macular", "lesion"], "h": {"id": "C0332573", "name": "C0332573#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [16, 17]}}
{"token": ["We", "also", "found", "that", "basal", "production", "of", "superoxide", "was", "increased", "in", "diabetic", "compared", "to", "C0362046#ent", "<e1>", "rats", "and", "that", "C2350800#ent", "<e2>", "decreased", "this", "basal", "production", "superoxide", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2350800", "name": "C2350800#ent", "pos": [19, 20]}}
{"token": ["Clinical", "trials", "aldosterone", "antagonists", "an", "improvement", "in", "survival", "and", "left", "ventricular", "mass", "index", "patients", "with", "congestive", "heart", "failure", "and", "a", "reduction", "in", "C1420369#ent", "<e1>", "excretion", "and", "left", "ventricular", "mass", "index", "patients", "with", "type", "2", "diabetes", "early", "nephropathy", "developed", "C1527416#ent", "<e2>", "escape", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1527416", "name": "C1527416#ent", "pos": [38, 39]}}
{"token": ["Our", "data", "strongly", "suggest", "that", "chronic", "administration", "an", "LHRH", "C0243192#ent", "<e1>", "may", "induce", ",", "after", "cessation", "of", "treatment", ",", "an", "C0001622#ent", "<e2>", "of", "testicular", "steroids", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [20, 21]}}
{"token": ["The", "simultaneous", "presence", "of", "C0012695#ent", "<e1>", "and", "A23187", "in", "the", "binding", "buffer", "in", "a", "decrease", "in", "C0028127#ent", "<e2>", "binding", "to", "below", "detectable", "levels", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028127", "name": "C0028127#ent", "pos": [16, 17]}}
{"token": ["Addition", "of", "xylitol", ",", "a", "precursor", "of", "xylulose-5-phosphate", ",", "to", "primary", "rat", "hepatocytes", "increased", "C1417825#ent", "<e1>", "expression", "to", "a", "comparable", "level", "as", "C0017718#ent", "<e2>", "."], "h": {"id": "C1417825", "name": "C1417825#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017718", "name": "C0017718#ent", "pos": [22, 23]}}
{"token": ["C1608529#ent", "<e1>", "MKP3", ")", "is", "a", "C1335554#ent", "<e2>", "PTP", ")", "for", "which", "in", "vivo", "evidence", "suggests", "that", "regulation", "can", "occur", "by", "oxidation", "and/or", "reduction", "of", "the", "active", "site", "cysteine", "."], "h": {"id": "C1608529", "name": "C1608529#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "the", "inhibitory", "actions", "of", "C1822764#ent", "<e1>", "were", "significantly", "greater", "in", "rats", "that", "had", "received", "C0126174#ent", "<e2>", "and", "prazosin", "as", "compared", "with", "rats", "that", "received", "C0126174#ent", "<e2>", "and", "rauwolscine", "."], "h": {"id": "C1822764", "name": "C1822764#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [16, 17]}}
{"token": ["MJ", "and", "C0015075#ent", "<e1>", "but", "not", "C0066282#ent", "<e2>", "enhanced", "phenolic", "synthesis", "polyphenolic", "parenchyma", "cells", ",", "early", "sclereid", "lignification", ",", "and", "reprogramming", "of", "the", "cambial", "zone", "to", "form", "traumatic", "resin", "ducts", "in", "Pseudotsuga", "menziesii", "Sequoiadendron", "giganteum"], "h": {"id": "C0015075", "name": "C0015075#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0066282", "name": "C0066282#ent", "pos": [6, 7]}}
{"token": ["We", "detected", "C1416585#ent", "<e1>", "expression", "in", "tissue", "specimens", "patients", "with", "non-small", "cell", "lung", "cancers", "C1704939#ent", "<e2>", ")", "and", "assessed", "their", "clinical", "characteristics"], "h": {"id": "C1416585", "name": "C1416585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [14, 15]}}
{"token": ["The", "recombinant", "NF-kappa", "B", "50-kDa", "subunit", "used", "as", "an", "immunogen", "to", "produce", "a", "rabbit", "antiserum", "which", "was", "then", "affinity-purified", "using", "a", "portion", "of", "the", "C0905070#ent", "<e1>", "does", "not", "have", "homology", "to", "other", "members", "of", "the", "C0035018#ent", "<e2>"], "h": {"id": "C0905070", "name": "C0905070#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0035018", "name": "C0035018#ent", "pos": [35, 36]}}
{"token": ["Thus", ",", "we", "renamed", "our", "ocp11", "mutant", "C2827475#ent", "<e1>", "-", "2", ",", "as", "it", "represents", "a", "different", "C1706112#ent", "<e2>", "to", "the", "previously", "characterized", "recessive", "C2827475#ent", "<e1>", "-", "1", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2827475", "name": "C2827475#ent", "pos": [7, 8]}}
{"token": ["C0037140#ent", "<e1>", "the", "lacrimal", "gland", "investigated", "as", "an", "etiologic", "factor", "C0013238#ent", "<e2>", "patients", "who", "were", "positive", "for", "human", "immunodeficiency", "virus", "HIV", ")", "."], "h": {"id": "C0037140", "name": "C0037140#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013238", "name": "C0013238#ent", "pos": [10, 11]}}
{"token": ["Although", "these", "C0812325#ent", "<e1>", "mRNA", "levels", "showed", "little", "change", "in", "C0268731#ent", "<e2>", "until", "Day", "20", ",", "all", "C0812325#ent", "<e1>", "mRNA", "levels", "increased", "in", "C0268731#ent", "<e2>", "during", "the", "sclerotic", "phase", "PAN", "nephrosis", "glomerular", "sclerosis", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [2, 3]}}
{"token": ["The", "method", "was", "applied", "to", "wash-outs", "from", "21", "healthy", "volunteers", "18", "patients", "with", "C0600260#ent", "<e1>", "two", "subjects", "with", "C0741804#ent", "<e2>"], "h": {"id": "C0600260", "name": "C0600260#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0741804", "name": "C0741804#ent", "pos": [18, 19]}}
{"token": ["C0058629#ent", "<e1>", "aggregation", "with", "no", "effect", "activity", "or", "any", "conformational", "parameter", "native", "C0014442#ent", "<e2>", "."], "h": {"id": "C0058629", "name": "C0058629#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["C0217476#ent", "<e1>", "was", "found", "to", "be", "a", "C1458146#ent", "<e2>", "II", "inhibitor", "with", "DNA", "sites", "enzyme", "inhibition", "being", "different", "for", "these", "two", "enzymes", "."], "h": {"id": "C0217476", "name": "C0217476#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [7, 8]}}
{"token": ["C0217476#ent", "<e1>", ",", "an", "antitumor", "drug", "interacts", "with", "both", "C1458146#ent", "<e2>", "II", ",", "has", "demonstrated", "a", "broad", "spectrum", "of", "activity", "in", "preclinical", "studies"], "h": {"id": "C0217476", "name": "C0217476#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [9, 10]}}
{"token": ["C0217476#ent", "<e1>", "induced", "both", "C1458146#ent", "<e2>", "II-mediated", "DNA", "strand", "breaks", ",", "using", "purified", "topoisomerases", "."], "h": {"id": "C0217476", "name": "C0217476#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [4, 5]}}
{"token": ["A", "36", "year", "old", "patient", "known", "to", "suffer", "from", "the", "C0023138#ent", "<e1>", "LMBBS", ")", "developed", "C0270790#ent", "<e2>"], "h": {"id": "C0023138", "name": "C0023138#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0270790", "name": "C0270790#ent", "pos": [15, 16]}}
{"token": ["Immunocytochemistry", "demonstrated", "the", "presence", "of", "all", "three", "C0599220#ent", "<e1>", "in", "principal", "cells", "the", "CNT", ",", "C0008928#ent", "<e2>", ",", "OMCD", ",", "and", "IMCD", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008928", "name": "C0008928#ent", "pos": [15, 16]}}
{"token": ["Conversely", ",", "there", "is", "a", "collection", "of", "C0543793#ent", "<e1>", "phagocyte", "function", "result", "not", "only", "in", "immunodeficiency", "but", "also", "in", "C0010346#ent", "<e2>"], "h": {"id": "C0543793", "name": "C0543793#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [19, 20]}}
{"token": ["In", "recent", "years", "it", "has", "been", "postulated", "that", "C0029899#ent", "<e1>", "frequently", "produces", "a", "pure", "C0452138#ent", "<e2>", "stapedial", "involvement", "."], "h": {"id": "C0029899", "name": "C0029899#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0452138", "name": "C0452138#ent", "pos": [14, 15]}}
{"token": ["Intravenous", "injection", "of", "C0000981#ent", "<e1>", "after", "administration", "of", "C0022092#ent", "<e2>", "caused", "a", "small", "additional", "decrease", "in", "image", "intensity"], "h": {"id": "C0000981", "name": "C0000981#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022092", "name": "C0022092#ent", "pos": [8, 9]}}
{"token": ["Adenosine", "diphosphate", "expression", "of", "P-selectin", "and", "of", "C3889731#ent", "<e1>", "was", "significantly", "reduced", "after", "2", "wk", "of", "C0070166#ent", "<e2>", "but", "not", "of", "ASA", "treatment", "."], "h": {"id": "C3889731", "name": "C3889731#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0070166", "name": "C0070166#ent", "pos": [16, 17]}}
{"token": ["The", "ability", "of", "C1706044#ent", "<e1>", "to", "transactivate", "the", "C1705633#ent", "<e2>", "up", "to", "1,000-fold", ")", "depended", "entirely", "on", "the", "presence", "of", "intact", "GC", "and", "TATA", "box", "sequences"], "h": {"id": "C1706044", "name": "C1706044#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [8, 9]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "compare", "the", "effects", "of", "C0116569#ent", "<e1>", "with", "those", "of", "C0023660#ent", "<e2>", "(", "lignocaine", ")", "and", "fentanyl", "on", "prevention", "of", "tachycardia", "and", "hypertension", "caused", "by", "endotracheal", "intubation"], "h": {"id": "C0116569", "name": "C0116569#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [16, 17]}}
{"token": ["Consistently", ",", "ASC", "recruited", "C0667830#ent", "<e1>", "and", "CLARP", "but", "not", "FADD", "and", "C1420307#ent", "<e2>", "to", "its", "speck-like", "aggregates", "in", "cells", "."], "h": {"id": "C0667830", "name": "C0667830#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420307", "name": "C1420307#ent", "pos": [12, 13]}}
{"token": ["Magnetically", "generated", "forces", "were", "applied", "to", "protein-coated", "magnetite", "beads", "bound", "to", "human", "gingival", "fibroblasts", ",", "cells", "with", "C0669365#ent", "<e1>", "low", "basal", "levels", "of", "C1414635#ent", "<e2>", "mRNA", "and", "protein", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414635", "name": "C1414635#ent", "pos": [23, 24]}}
{"token": ["The", "focus", "on", "the", "molecular", "aspects", "be", "helpful", "in", "predicting", "the", "potential", "advantages", "of", "selective", "GR", "C2987634#ent", "<e1>", "in", "comparison", "to", "classical", "C1415097#ent", "<e2>", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415097", "name": "C1415097#ent", "pos": [22, 23]}}
{"token": ["Quantification", "of", "C1823242#ent", "<e1>", "mRNA", "in", "human", "striatum", "has", "revealed", "reduced", "levels", "in", "C4255233#ent", "<e2>", "patients", "compared", "with", "control", "individuals"], "h": {"id": "C1823242", "name": "C1823242#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4255233", "name": "C4255233#ent", "pos": [13, 14]}}
{"token": ["However", ",", "it", "is", "noteworthy", "that", "the", "gene", "for", "C0013423#ent", "<e1>", "also", "been", "localized", "by", "genetic", "studies", "C0795833#ent", "<e2>", ",", "the", "same", "regional", "map", "location", "as", "NMDAR1", "."], "h": {"id": "C0013423", "name": "C0013423#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0795833", "name": "C0795833#ent", "pos": [17, 18]}}
{"token": ["Kinesin-1", "drives", "the", "movement", "of", "diverse", "cargoes", ",", "and", "it", "has", "been", "proposed", "that", "specific", "kinesin", "light", "chain", "C3812221#ent", "<e1>", ")", "isoforms", "target", "C0085139#ent", "<e2>", "to", "these", "different", "structures", "."], "h": {"id": "C3812221", "name": "C3812221#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0085139", "name": "C0085139#ent", "pos": [23, 24]}}
{"token": ["Most", "interestingly", ",", "disruption", "of", "APC/C", "proteolysis", "of", "C1420747#ent", "<e1>", "and", "TMPK", "leads", "to", "growth", "retardation", "a", "striking", "increase", "in", "C0678941#ent", "<e2>", "rate", "."], "h": {"id": "C1420747", "name": "C1420747#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0678941", "name": "C0678941#ent", "pos": [20, 21]}}
{"token": ["The", "most", "commonly", "reported", "adverse", "events", "both", "drugs", "were", "C0010200#ent", "<e1>", ",", "dizziness", ",", "fall", "in", "blood", "pressure", "C0042571#ent", "<e2>", ",", "and", "myocardial", "infarction"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042571", "name": "C0042571#ent", "pos": [18, 19]}}
{"token": ["It", "was", "recently", "shown", "that", "stimulation", "of", "RAW264.7", "murine", "macrophages", "by", "LPS", ",", "LAM", ",", "STF", ",", "and", "C0812214#ent", "<e1>", "rapidly", "activated", "NF-kappaB", ",", "AP1", ",", "and", "C0169101#ent", "<e2>"], "h": {"id": "C0812214", "name": "C0812214#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [27, 28]}}
{"token": ["Both", "haloperidol", "and", "C0025641#ent", "<e1>", "antagonized", "the", "DA", "stimulation", "of", "C0001492#ent", "<e2>", "but", "only", "haloperidol", "decreased", "striatal", "ACh", "levels", "."], "h": {"id": "C0025641", "name": "C0025641#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [10, 11]}}
{"token": ["C0021400#ent", "<e1>", "the", "only", "C0042769#ent", "<e2>", "to", "have", "a", "statistically", "significant", "association", "with", "SIDS", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [4, 5]}}
{"token": ["We", "identified", "the", "C0298690#ent", "<e1>", "which", "encodes", "mitogen-activated", "protein", "kinase", "phosphatase", "2", "C1414185#ent", "<e2>", ")", ",", "as", "a", "HoxA10", "target", "gene", "."], "h": {"id": "C0298690", "name": "C0298690#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414185", "name": "C1414185#ent", "pos": [12, 13]}}
{"token": ["C0021246#ent", "<e1>", "significantly", "attenuated", "the", "C0596110#ent", "<e2>", ",", "natriuretic", "and", "chloruretic", "effects", "of", "furosemide", "without", "significantly", "affecting", "inulin", "and", "p-aminohippurate", "clearance", "or", "filtration", "fraction"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [5, 6]}}
{"token": ["C0021246#ent", "<e1>", "acted", "as", "an", "C0596110#ent", "<e2>", "in", "6", "week", "Wistar-Kyoto", "rats", "WKY", ")", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [5, 6]}}
{"token": ["It", "was", "therefore", "concluded", "that", "C0004147#ent", "<e1>", "medication", "was", "a", "useful", "treatment", "of", "C0020538#ent", "<e2>", "did", "not", "reduce", "the", "normal", "working", "ability", "and", "exercise", "tolerance"], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [13, 14]}}
{"token": ["A", "significantly", "age-", "and", "gender-adjusted", "odds", "ratio", "of", "2.0", "for", "the", "development", "of", "C0004153#ent", "<e1>", "observed", "in", "study", "subjects", "with", "C3642141#ent", "<e2>", "APOE", "than", "those", "without", "C3642141#ent", "<e2>"], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [13, 14]}, "relation": "disease_has_associated_gene", "t": {"id": "C3642141", "name": "C3642141#ent", "pos": [20, 21]}}
{"token": ["Atrophy", "of", "intracranial", "structures", "not", "seen", "in", "patients", "with", "the", "pure", "type", "of", "C1863704#ent", "<e1>", "or", "in", "early", "cases", "of", "C0016719#ent", "<e2>"], "h": {"id": "C1863704", "name": "C1863704#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0016719", "name": "C0016719#ent", "pos": [20, 21]}}
{"token": ["Inhibitors", "of", "protein", "phosphatase", "1", "PP1", ")", ",", "protein", "kinase", "C", "PKC", ")", ",", "protein", "tyrosine", "kinase", "C1705341#ent", "<e1>", ")", ",", "calmodulin", "and", "calmodulin-dependent", "kinase-II", "CamK", "II", "prevented", "C1334146#ent", "<e2>", "expression", "on", "cisplatin-treated", "macrophages", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334146", "name": "C1334146#ent", "pos": [28, 29]}}
{"token": ["Alternatively", ",", "C1527149#ent", "<e1>", "may", "physically", "interact", "with", "C0062507#ent", "<e2>", "thereby", "protecting", "the", "enzyme", "from", "thermal", "denaturation", "."], "h": {"id": "C1527149", "name": "C1527149#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0062507", "name": "C0062507#ent", "pos": [8, 9]}}
{"token": ["Erythromycin", "and", "other", "parental", "antibiotics", "were", "administered", ",", "but", "C1145670#ent", "<e1>", "promptly", ",", "followed", "by", "multiple", "organ", "failure", "syndrome", "involved", "the", "C0023899#ent", "<e2>", ",", "lung", ",", "bone", "marrow", "kidney", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "C0009014#ent", "<e1>", "inhibited", "the", "FFA", "outflow", "initiated", "by", "theophylline", "associated", "with", "C1412179#ent", "<e2>"], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "EAA", "was", "blocked", "by", "physiological", "concentration", "of", "C1333909#ent", "<e1>", "+", ",", "with", "the", "exception", "of", "C0022471#ent", "<e2>"], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [18, 19]}}
{"token": ["Retroviral", "transduction", "null", "precursors", "C2987364#ent", "<e1>", "or", "mutant", "DAP12", "or", "C0134982#ent", "<e2>", "reveals", "that", "the", "SH2", "domain", "C0134982#ent", "<e2>", "and", "the", "ITAM", "tyrosine", "residues", "and", "transmembrane", "domain", "DAP12", "mediate", "M-CSF", "signaling", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0134982", "name": "C0134982#ent", "pos": [10, 11]}}
{"token": ["Desensitization", "is", "a", "reflection", "of", "a", "conformational", "change", "the", "C1418944#ent", "<e1>", "the", "excitation", "caused", "by", "C2987634#ent", "<e2>", "."], "h": {"id": "C1418944", "name": "C1418944#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [15, 16]}}
{"token": ["The", "content", "of", "C12:0", "(", "2-OH", ")", "EM", "substituents", "reached", "high", "levels", "306", "nmol/mg-EM", ",", "64.4", "mol%", "of", "total", "C1539477#ent", "<e1>", ")", "by", "selectively", "feeding", "this", "C0015625#ent", "<e2>", "."], "h": {"id": "C1539477", "name": "C1539477#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [26, 27]}}
{"token": ["To", "clarify", "the", "issue", ",", "we", "examined", "the", "C2698259#ent", "<e1>", "FG", "by", "C0017351#ent", "<e2>", "gene", "rearrangement"], "h": {"id": "C2698259", "name": "C2698259#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017351", "name": "C0017351#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "C2698259#ent", "<e1>", "analyzed", "for", "C0017351#ent", "<e2>", "gene", "rearrangement", "the", "polymerase", "chain", "reaction", "the", "site", "of", "the", "lymphoma", "lesion", ",", "transitional", "lesion", "and", "the", "non-lymphoma", "lesion", "."], "h": {"id": "C2698259", "name": "C2698259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017351", "name": "C0017351#ent", "pos": [7, 8]}}
{"token": ["After", "SP", ",", "the", "NKA", "concentration", "was", "highest", "and", "C1420564#ent", "<e1>", "concentration", "was", "lowest", "in", "all", "regions", "except", "for", "the", "C0001614#ent", "<e2>", "and", "hippocampus", "where", "the", "NPK", "concentration", "was", "highest", "."], "h": {"id": "C1420564", "name": "C1420564#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [20, 21]}}
{"token": ["Blood", "E(2", ")", "levels", "at", "time", "of", "sacrifice", "correlated", "closely", "with", "activities", "of", "striatal", "C1136197#ent", "<e1>", ",", "GST", ",", "and", "C3813590#ent", "<e2>", ",", "but", "not", "with", "striatal", "UGT", "."], "h": {"id": "C1136197", "name": "C1136197#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3813590", "name": "C3813590#ent", "pos": [20, 21]}}
{"token": ["ASCOT", "compared", "the", "effect", "of", "atenolol", "combined", "with", "a", "C0873164#ent", "<e1>", "versus", "amlodipine", "with", "C0136123#ent", "<e2>", "in", "hypertensive", "patients", "."], "h": {"id": "C0873164", "name": "C0873164#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0136123", "name": "C0136123#ent", "pos": [14, 15]}}
{"token": ["Northern", "blot", "immunohistochemistry", "for", "the", "expression", "of", "a", "recently", "described", "C1334706#ent", "<e1>", "(", "MMP", ")", ",", "the", "C1568288#ent", "<e2>", "(", "membrane-type", "matrix", "metalloproteinase", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1568288", "name": "C1568288#ent", "pos": [17, 18]}}
{"token": ["His", "medical", "history", "C0340288#ent", "<e1>", "control", "with", "C0022252#ent", "<e2>", "and", "nifedipine", "."], "h": {"id": "C0340288", "name": "C0340288#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022252", "name": "C0022252#ent", "pos": [7, 8]}}
{"token": ["C0002878#ent", "<e1>", "folate", "or", "vitamin", "B12", "deficiency", "C1418558#ent", "<e2>", "ruled", "out", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418558", "name": "C1418558#ent", "pos": [7, 8]}}
{"token": ["Serum", "iron", ",", "hemoglobin", ",", "and", "reticulocytes", "were", "determined", "in", "134", "patients", "with", "C0002878#ent", "<e1>", "hereditary", "spherocytosis", "pyruvate", "kinase-", "glucose-phosphate", "isomerase", "deficiency", "C0002878#ent", "<e1>", "to", "warm", "auto", "antibodies", ",", "cold", "agglutinin", "disease", "C1418558#ent", "<e1>", "hemolytic", "uremic", "syndrome", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418558", "name": "C1418558#ent", "pos": [32, 33]}}
{"token": ["In", "addition", ",", "C1416577#ent", "<e1>", ",", "C1416582#ent", "<e2>", "and", "Kir5.1", "inward", "rectifier", "channels", "investigated", "using", "RT-PCR", "and", "immunohistochemistry", "(", "C1416577#ent", "<e1>", ")", "."], "h": {"id": "C1416582", "name": "C1416582#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416577", "name": "C1416577#ent", "pos": [3, 4]}}
{"token": ["In", "cases", "of", "C0013502#ent", "<e1>", "of", "the", "right", "lung", "preoperative", "search", "should", "be", "made", "for", "C0038565#ent", "<e2>", "concomitant", "liver", "cyst", "can", "be", "removed", "through", "the", "same", "thoracotomy", "."], "h": {"id": "C0013502", "name": "C0013502#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038565", "name": "C0038565#ent", "pos": [15, 16]}}
{"token": ["Pretreatment", "with", "SC46275", "desensitized", "mice", "the", "subsequent", "C0237795#ent", "<e1>", "effect", "of", "C0075628#ent", "<e2>", ",", "but", "the", "vasodepressor", "effect", "of", "PGE(2)", "EP(2)(+/+", ")", "mice", "remained", "intact", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0075628", "name": "C0075628#ent", "pos": [11, 12]}}
{"token": ["Transfection", "analysis", "us", "to", "further", "establish", "that", "the", "C1258132#ent", "<e1>", "ADAM10", "but", "not", "ADAM17", "(", "TACE", ",", "C1412186#ent", "<e2>", "likely", "contribute", "to", "constitutive", "sAPPalpha", "secretion", "by", "LoVo", "cells", "."], "h": {"id": "C1258132", "name": "C1258132#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412186", "name": "C1412186#ent", "pos": [17, 18]}}
{"token": ["EFFECTS", "OF", "VERAPAMIL", "AND", "C0076891#ent", "<e1>", ":", "Progression", "of", "C0018801#ent", "<e2>", "sudden", "death", "death", "from", "re-infarction", "are", "the", "major", "cause", "of", "the", "increased", "mortality", "in", "postinfarct", "patients", "with", "congestive", "heart", "failure"], "h": {"id": "C0076891", "name": "C0076891#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [9, 10]}}
{"token": ["A", "case", "of", "C0011608#ent", "<e1>", "a", "60-year-old", "woman", "with", "C3149841#ent", "<e2>", "hemodialysis", "is", "reported", "."], "h": {"id": "C0011608", "name": "C0011608#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [9, 10]}}
{"token": ["However", ",", "C0085786#ent", "<e1>", "supplementation", "did", "not", "affect", "DMI", ",", "C3273406#ent", "<e2>", ",", "or", "feed", "efficiency", "in", "steers", "or", "heifers", "(", "P", "<", ".05", ")", "."], "h": {"id": "C0085786", "name": "C0085786#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [10, 11]}}
{"token": ["Twenty-nine", "women", "with", "C0029458#ent", "<e1>", "treated", "with", "estrogen", "(", "HRT", ")", "or", "C0618111#ent", "<e2>", "for", "12", "months", "."], "h": {"id": "C0029458", "name": "C0029458#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0618111", "name": "C0618111#ent", "pos": [12, 13]}}
{"token": ["The", "combination", "of", "C0113293#ent", "<e1>", "and", "midazolam", "enhanced", "the", "duration", "of", "lateral", "recumbency", "reduced", "the", "C0020456#ent", "<e2>", "induced", "by", "C0113293#ent", "<e1>", "alone", "."], "h": {"id": "C0113293", "name": "C0113293#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [15, 16]}}
{"token": ["The", "increasing", "of", "content", "C1522405#ent", "<e1>", "and", "interleukin-4", "in", "blood", "was", "noted", "in", "rats", "C0342895#ent", "<e2>", "inulin", "and", "oligofructose", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [14, 15]}}
{"token": ["To", "study", "the", "effect", "of", "C1707190#ent", "<e1>", "the", "most", "common", "CYP2C8", "variant", "C1706112#ent", "<e2>", "on", "the", "dis-position", "of", "(R)-ibuprofen", "and", "the", "association", "of", "C1707190#ent", "<e1>", "variant", "CYP2C9", "alleles"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1707190", "name": "C1707190#ent", "pos": [5, 6]}}
{"token": ["Two", "of", "the", "novel", "C1417679#ent", "<e1>", "contain", "zinc", "finger", "domains", "are", "designated", "ZNF366", "and", "C3273674#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273674", "name": "C3273674#ent", "pos": [14, 15]}}
{"token": ["Patient", "2", "autonomous", "hyperparathyroidism", "associated", "with", "C1561643#ent", "<e1>", "and", "patient", "3", "with", "C0733682#ent", "<e2>", ",", "developed", "autonomous", "hyperparathyroidism", "8", "years", "of", "therapy", "with", "Pi", "and", "calcitriol", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0733682", "name": "C0733682#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "the", "C4307669#ent", "<e1>", "PD", "098059", "blocked", "CD2-mediated", "activation", "of", "C0170168#ent", "<e2>", "had", "no", "effect", "CD2-induced", "adhesion", "."], "h": {"id": "C4307669", "name": "C4307669#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [11, 12]}}
{"token": ["Desquamative", "gingivitis", "a", "clinical", "term", "describe", "red", ",", "painful", ",", "glazed", "and", "friable", "gingivae", "which", "may", "be", "a", "manifestation", "of", "some", "C0006848#ent", "<e1>", "conditions", "such", "as", "lichen", "planus", "the", "C0037275#ent", "<e2>"], "h": {"id": "C0006848", "name": "C0006848#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0037275", "name": "C0037275#ent", "pos": [29, 30]}}
{"token": ["The", "dose", "response", "relationship", "to", "C0050559#ent", "<e1>", "in", "five", "patients", "with", "C0017925#ent", "<e2>", "investigated", "."], "h": {"id": "C0050559", "name": "C0050559#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017925", "name": "C0017925#ent", "pos": [11, 12]}}
{"token": ["Four", "weeks", "later", ",", "while", "still", "receiving", "C0034414#ent", "<e1>", ",", "she", "developed", "C0022073#ent", "<e2>"], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022073", "name": "C0022073#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "show", "that", "HSV-1", "Us11", "protein", "able", "to", "bind", "Rex-", "and", "C0080117#ent", "<e1>", "to", "transactivate", "C0017343#ent", "<e2>", "expression", "."], "h": {"id": "C0080117", "name": "C0080117#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017343", "name": "C0017343#ent", "pos": [16, 17]}}
{"token": ["All", "of", "these", "experimental", "results", "that", "multiwalled", "carbon", "nanotubes", "could", "be", "used", "as", "a", "valuable", "alternative", "C0350056#ent", "<e1>", "for", "the", "SPE", "of", "C0038766#ent", "<e2>", "herbicides", "in", "many", "real", "water", "samples"], "h": {"id": "C0350056", "name": "C0350056#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [22, 23]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "the", "validity", "of", "the", "Patient", "Evaluation", "Measure", "questionnaire", "C0270700#ent", "<e1>", ")", "as", "an", "outcome", "measure", "C0007286#ent", "<e2>"], "h": {"id": "C0270700", "name": "C0270700#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [23, 24]}}
{"token": ["Absence", "of", "C1414863#ent", "<e1>", "is", "of", "interest", ",", "as", "Se", "deficiency", "associated", "with", "C0267952#ent", "<e2>", "experimental", "animals", "it", "is", "often", "noted", "in", "chronic", "alcoholics", "and", "the", "malnourished", "."], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0267952", "name": "C0267952#ent", "pos": [13, 14]}}
{"token": ["Glomeruli", "and", "glomerular", "cell", "membranes", "extracted", "sequentially", "with", "C0146951#ent", "<e1>", "followed", "by", "DNase", "I", "C0885483#ent", "<e2>", "depolymerize", "actin", "."], "h": {"id": "C0146951", "name": "C0146951#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0885483", "name": "C0885483#ent", "pos": [14, 15]}}
{"token": ["Pepsins", "C", "D", "and", "probably", "C0312136#ent", "<e1>", "well", "as", "the", "major", "C0014442#ent", "<e2>", "been", "detected", "on", "starch-gel", "electrophoretograms", "of", "concentrates", "of", "the", "gastric", "contents", "of", "four", "pigs", "."], "h": {"id": "C0312136", "name": "C0312136#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "the", "alternative", "chelation", "program", "effective", "in", "reducing", "iron", "overload", "C0039730#ent", "<e1>", "patients", ",", "protecting", "them", "also", "against", "C0018799#ent", "<e2>"], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [20, 21]}}
{"token": ["Nevertheless", ",", "the", "recovered", "mutant", "C3541394#ent", "<e1>", "were", "barely", "able", "to", "phosphorylate", "C2697642#ent", "<e2>", "either", "in", "vitro", "after", "expression", "in", "an", "aceK", "(", "-", ")", "mutant", "strain", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2697642", "name": "C2697642#ent", "pos": [12, 13]}}
{"token": ["Expression", "of", "a", "C1366498#ent", "<e1>", "cat", ")", "controlled", "by", "the", "pdc", "gene", "resulted", "in", "C0014442#ent", "<e2>", "activities", "of", "up", "to", "5.5", "U/mg", "total", "cell", "protein", "Z.", "mobilis", "cells", "."], "h": {"id": "C1366498", "name": "C1366498#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["There", "are", "two", "major", "syndromes", "presenting", "in", "the", "early", "decades", "life", "with", "dystonia", "and", "C0242422#ent", "<e1>", ":", "dopa-responsive", "dystonia", "DRD", ")", "and", "C2677567#ent", "<e2>", "EOIP", ")", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C2677567", "name": "C2677567#ent", "pos": [22, 23]}}
{"token": ["This", "inflammatory", "dysfunction", "be", "reversed", "by", "a", "dominant-negative", "I", "kappa", "B", "prevents", "nuclear", "translocation", "C2986464#ent", "<e1>", "have", "developed", "antigen-specific", ",", "antigen-presenting", "cells", "express", "high", "levels", "of", "C1706006#ent", "<e2>", "that", "can", "prevent", "tissue-specific", "inflammatory", "disease"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [26, 27]}}
{"token": ["C0034186#ent", "<e1>", "a", "rare", "gas-producing", "C0004623#ent", "<e2>", "the", "renal", "parenchyma", "primarily", "in", "patients", "with", "diabetes", "mellitus"], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [5, 6]}}
{"token": ["C0034186#ent", "<e1>", "is", "the", "most", "common", "severe", "C0004623#ent", "<e2>", "complicating", "pregnancy", "."], "h": {"id": "C0034186", "name": "C0034186#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "our", "results", "demonstrated", "that", "C0015133#ent", "<e1>", "exposure", "elicited", "a", "rapid", "increase", "in", "the", "activity", "of", "C0669516#ent", "<e2>", "intracellular", "peroxides", "levels", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [17, 18]}}
{"token": ["The", "inhibitory", "activity", "of", "six", "groups", "of", "C1257966#ent", "<e1>", "against", "yeast", "and", "rat", "small", "intestinal", "C0002272#ent", "<e2>", "and", "porcine", "pancreatic", "alpha-amylase", "compared", ",", "and", "chemical", "structures", "C1257966#ent", "<e1>", "responsible", "for", "the", "inhibitory", "activity", "evaluated", "."], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1257966", "name": "C1257966#ent", "pos": [7, 8]}}
{"token": ["To", "examine", "the", "effect", "of", "methotrexate", "(", "C0025677#ent", "<e1>", ")", "administered", "in", "vivo", "the", "production", "of", "the", "C1412361#ent", "<e2>", "(", "5-LO", ")", "metabolites", "of", "arachidonic", "acid", "neutrophils", "from", "subjects", "with", "rheumatoid", "arthritis"], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412361", "name": "C1412361#ent", "pos": [17, 18]}}
{"token": ["Expression", "of", "hTR", "and", "telomeric-associated", "proteins", "TEP1", ",", "TRF1", ",", "C1704998#ent", "<e1>", ",", "tankyrase", "and", "C3273282#ent", "<e2>", "was", "high", "in", "the", "majority", "of", "CP", "and", "AP", "patients", "."], "h": {"id": "C1704998", "name": "C1704998#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273282", "name": "C3273282#ent", "pos": [15, 16]}}
{"token": ["route", "proved", "to", "be", "more", "potent", "and", "longer-acting", "than", "disopyramide", ",", "propaphenone", "and", "C0543459#ent", "<e1>", "against", "supraventricular", "and", "ventricular", "arrhythmias", "induced", "by", "chloroform", ",", "C0001159#ent", "<e2>", ",", "ouabain", "and", "halothane-adrenaline", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001159", "name": "C0001159#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "indicate", "that", "at", "least", "some", "of", "the", "calcium", "abnormalities", "in", "the", "pathogenesis", "of", "hypertension", "could", "be", "the", "result", "of", "interactions", "between", "CaM", ",", "C2936886#ent", "<e1>", ",", "and", "this", "C1422492#ent", "<e2>", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [30, 31]}}
{"token": ["Stimulation", "with", "C2936886#ent", "<e1>", "led", "to", "markedly", "enhanced", "levels", "of", "C1422492#ent", "<e2>", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [10, 11]}}
{"token": ["C0041296#ent", "<e1>", "patients", "under", "therapy", "with", "the", "drug", "combination", "isoniazid", "INH", ")", "and", "C0030125#ent", "<e2>", "PAS", ")", "were", "screened", "to", "investigate", "the", "cytogenetic", "effects"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0030125", "name": "C0030125#ent", "pos": [13, 14]}}
{"token": ["We", "also", "showed", "that", "the", "CpG", "sites", "in", "the", "C0525037#ent", "<e1>", "were", "methylated", "by", "overexpression", "of", "C0919490#ent", "<e2>", "in", "NIH3T3", "cells", ",", "accompanied", "by", "a", "downregulation", "of", "C0525037#ent", "<e1>", "gene", "expression"], "h": {"id": "C0919490", "name": "C0919490#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [9, 10]}}
{"token": ["Importantly", ",", "we", "further", "show", "that", "phosphorylation", "at", "Ser216", "by", "phospho-ERK1/2", "promotes", "C1413259#ent", "<e1>", "ubiquitination", "and", "proteasomal", "degradation", "suggesting", "that", "C1413259#ent", "<e1>", "proteolysis", "is", "required", "for", "a", "sustained", "G2", "arrest", "response", "to", "C1705280#ent", "<e1>", "."], "h": {"id": "C1413259", "name": "C1413259#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [32, 33]}}
{"token": ["Here", "we", "show", "that", "the", "inhibition", "of", "the", "MgATPase", "activity", "C0007913#ent", "<e1>", "deficient", "in", "its", "epsilon", "subunit", "CF1-epsilon", ")", "by", "C1333909#ent", "<e2>", "+", "is", "complex", "."], "h": {"id": "C0007913", "name": "C0007913#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [20, 21]}}
{"token": ["Apart", "from", "its", "importance", "in", "cervical", "region", "anesthesia", "surgery", ",", "such", "an", "anatomical", "structure", "lead", "to", "several", "clinical", "conditions", "both", "by", "C3812627#ent", "<e1>", "and", "compression", "such", "as", "C0751549#ent", "<e2>"], "h": {"id": "C3812627", "name": "C3812627#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0751549", "name": "C0751549#ent", "pos": [27, 28]}}
{"token": ["Other", "serine", "and", "C0033607#ent", "<e1>", "well", "as", "TIMP-2", "and", "C0257710#ent", "<e2>", "(", "natural", "tissue", "and", "synthetic", "inhibitor", "matrix", "metalloproteinases", "MMPs", "]", ",", "respectively", ")", "were", "ineffective", "."], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0257710", "name": "C0257710#ent", "pos": [9, 10]}}
{"token": ["The", "synthetic", "opiate", "loperamide", "(", "LPMD", ")", "is", "an", "C0003292#ent", "<e1>", "affects", "both", "intestinal", "motility", "the", "transport", "of", "water", "and", "C3536863#ent", "<e2>", "."], "h": {"id": "C0003292", "name": "C0003292#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "iCNOP", "was", "equally", "effective", "to", "C2985165#ent", "<e1>", "in", "patients", "with", "ANHL", ",", "producing", "more", "leukopenia", "and", "C0015967#ent", "<e2>", "episodes", ",", "but", "less", "alopecia", "."], "h": {"id": "C2985165", "name": "C2985165#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [19, 20]}}
{"token": ["Protein", "kinase", "C", "PKC", ")", "C3889400#ent", "<e1>", "has", "been", "implicated", "as", "a", "mediator", "of", "C1367721#ent", "<e2>", "EGF", ")", "receptor", "(", "EGFR", ")", "signaling", "in", "certain", "cell", "types"], "h": {"id": "C3889400", "name": "C3889400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [14, 15]}}
{"token": ["Coding", "sequence", "analysis", "that", "C1422697#ent", "<e1>", "is", "a", "novel", "C0079429#ent", "<e2>", "that", "contains", "two", "consensus", "sequences", "nuclear", "localization", "signals"], "h": {"id": "C1422697", "name": "C1422697#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["On", "an", "8", "%", "NaCl", "C0235222#ent", "<e1>", "between", "8", "and", "16", "weeks", ",", "when", "the", "C4084890#ent", "<e2>", "was", "greater", "than", "previous", "levels", "."], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4084890", "name": "C4084890#ent", "pos": [15, 16]}}
{"token": ["We", "retested", "the", "C1332838#ent", "<e1>", "(", "true", "positives", "were", "sensitive", "on", "glucose", "caspofungin", "resistant", "on", "C0935942#ent", "<e2>", "media", ",", "respectively", ")", "."], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0935942", "name": "C0935942#ent", "pos": [15, 16]}}
{"token": ["C1332805#ent", "<e1>", "activity", "can", "be", "attributed", "to", "lysosomal", "C3540772#ent", "<e2>", "released", "from", "polymorphonuclear", "leukocytes", "are", "in", "close", "contact", "with", "glomerular", "basement", "membrane"], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [8, 9]}}
{"token": ["These", "double", "mutants", "inactive", "with", "respect", "to", "the", "total", "C0070823#ent", "<e1>", "the", "phosphoenolpyruvate-carbohydrate", "phosphotransferase", "system", "could", "not", "provide", "C0907533#ent", "<e2>", "synthesis", "of", "fructose-specific", "proteins", "of", "this", "system", "."], "h": {"id": "C0070823", "name": "C0070823#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [18, 19]}}
{"token": ["The", "first", "human", "trials", "of", "gene", "therapy", "C0085110#ent", "<e1>", "were", "conducted", "in", "1990", ",", "by", "attempting", "to", "insert", "the", "gene", "for", "C0001457#ent", "<e2>", "peripheral", "white", "blood", "cells", "treat", "children", "with", "C0001457#ent", "<e2>", "C0085110#ent", "<e1>", "."], "h": {"id": "C0001457", "name": "C0001457#ent", "pos": [21, 22]}, "relation": "gene_product_malfunction_associated_with_disease", "t": {"id": "C0085110", "name": "C0085110#ent", "pos": [7, 8]}}
{"token": ["C2699241#ent", "<e1>", "knockdown", "expression", "inhibited", "PKC", "delta", "activation", ",", "indicating", "that", "the", "activating", "role", "played", "by", "C3539607#ent", "<e2>", "depends", "upon", "the", "presence", "of", "C2699241#ent", "<e1>", "."], "h": {"id": "C3539607", "name": "C3539607#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2699241", "name": "C2699241#ent", "pos": [0, 1]}}
{"token": ["The", "efficacy", "and", "safety", "of", "video", "thoracoscopic", "lung", "biopsy", "(", "VTLB", ")", "and", "of", "open", "lung", "biopsy", "C1335230#ent", "<e1>", ")", "were", "compared", "in", "patients", "with", "C0024115#ent", "<e2>"], "h": {"id": "C1335230", "name": "C1335230#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [25, 26]}}
{"token": ["This", "pattern", "of", "localization", "and", "regulation", "is", "similar", "to", "that", "of", "Ipl1p", "C4277608#ent", "<e1>", "in", "higher", "eukaryotes", ",", "such", "as", "the", "human", "C1706168#ent", "<e2>"], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706168", "name": "C1706168#ent", "pos": [22, 23]}}
{"token": ["In", "the", "current", "study", ",", "C3273276#ent", "<e1>", "and", "N100", "were", "simultaneously", "recorded", "intra-", "and", "extracranially", "in", "C0014547#ent", "<e2>", "patients", "."], "h": {"id": "C3273276", "name": "C3273276#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [16, 17]}}
{"token": ["By", "studying", "the", "expression", "of", "C1332838#ent", "<e1>", "found", "that", "C0812246#ent", "<e2>", "could", "activate", "the", "zygotic", "genes", "Dorsal", "activates", "and", "repress", "the", "genes", "repressed", "by", "Dorsal", "."], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [9, 10]}}
{"token": ["The", "history", "of", "1", "of", "our", "patients", "indicates", "that", "severe", "C0221423#ent", "<e1>", "and", "of", "itself", "can", "cause", "C1135345#ent", "<e2>"], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1135345", "name": "C1135345#ent", "pos": [17, 18]}}
{"token": ["Expression", "of", "uPA", ",", "C1367689#ent", "<e1>", "uPAR", ")", ",", "and", "PAIs", "is", "regulated", "by", "growth", "factors", "C0037207#ent", "<e2>", ",", "and", "other", "effector", "molecules"], "h": {"id": "C1367689", "name": "C1367689#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037207", "name": "C0037207#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "the", "combination", "of", "diminished", "RNase", "H", "cleavage", "increased", "processivity", "renders", "the", "use", "of", "both", "PP(i", ")", "and", "ATP", "advantageous", ",", "whereas", "classic", "C1860224#ent", "<e1>", "solely", "enhance", "the", "C0059946#ent", "<e2>"], "h": {"id": "C1860224", "name": "C1860224#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [29, 30]}}
{"token": ["In", "contrast", ",", "C1851585#ent", "<e1>", "induced", "increases", "in", "total", "serum", "C3829362#ent", "<e2>", "(", "P<0.0001", ")", ",", "but", "not", "in", "CK18-Asp396", "(", "P=0.13", ")", "."], "h": {"id": "C1851585", "name": "C1851585#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3829362", "name": "C3829362#ent", "pos": [10, 11]}}
{"token": ["As", "well", "as", "slightly", "influencing", "the", "accumulation", "of", "[3H]-tryptophan", "by", "the", "neurone", "5,7-DHT", "inhibited", "the", "metabolism", "of", "this", "C2917660#ent", "<e1>", "form", "5-HT", ",", "probably", "by", "affecting", "the", "C1420870#ent", "<e2>"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [27, 28]}}
{"token": ["80", ",", "1712", "-", "1719", ")", "has", "demonstrated", "dose-dependent", ",", "saturable", ",", "and", "high", "affinity", "binding", "of", "C0032143#ent", "<e1>", "to", "two", "sites", "associated", "with", "cultural", "endothelial", "cell", "C0872351#ent", "<e2>", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [27, 28]}}
{"token": ["The", "C0059875#ent", "<e1>", "(", "Developmental", "Defects", "Enamel", ")", "Index", "was", "used", "to", "C0011351#ent", "<e2>", "enamel", "opacities"], "h": {"id": "C0059875", "name": "C0059875#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011351", "name": "C0011351#ent", "pos": [12, 13]}}
{"token": ["The", "specific", ",", "C1721278#ent", "<e1>", "the", "avian", "oviduct", "progesterone", "receptor", "PR", ")", "with", "target-cell", "nuclei", "and", "C0008546#ent", "<e2>", "has", "been", "shown", "to", "involve", "DNA", "complexed", "with", "specific", "chromatin", "acceptor", "proteins", "."], "h": {"id": "C1721278", "name": "C1721278#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [16, 17]}}
{"token": ["Deoxycytidine", "kinase", "dCK", ")", "and", "C0057429#ent", "<e1>", "dGK", ")", "are", "important", "enzymes", "for", "phosphorylation/activation", "of", "C0011522#ent", "<e2>", "."], "h": {"id": "C0057429", "name": "C0057429#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [15, 16]}}
{"token": ["Human", "mast", "cells", "normal", "tissues", "the", "tumor", "cells", "C2748503#ent", "<e1>", "expressed", "STG", "I", "as", "well", "as", "C1704347#ent", "<e2>", "tryptase", ")", "and", "c-kit", "."], "h": {"id": "C2748503", "name": "C2748503#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704347", "name": "C1704347#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "the", "value", "of", "the", "ankle-brachial", "systolic", "pressure", "index", "C1705674#ent", "<e1>", ")", "as", "a", "test", "for", "the", "diagnosis", "of", "C1306889#ent", "<e2>", "PAOD", ")", "in", "general", "practice"], "h": {"id": "C1705674", "name": "C1705674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1306889", "name": "C1306889#ent", "pos": [20, 21]}}
{"token": ["Nevertheless", ",", "p2mIME", "cells", "from", "Gadd45b(-/-", ")", ",", "Gadd45g(-/-", ")", ",", "and", "C1414928#ent", "<e1>", "mice", "survive", "elevation", "of", "C1412125#ent", "<e2>", "(", "or", "urea", ")", "essentially", "the", "same", "as", "do", "wild-type", "cells", "."], "h": {"id": "C1414928", "name": "C1414928#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [18, 19]}}
{"token": ["When", "evaluating", "antioxidant", "capacity", "C1257966#ent", "<e1>", ",", "their", "ability", "to", "modulate", "C1418881#ent", "<e2>", "expression", "should", "also", "be", "taken", "into", "consideration", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418881", "name": "C1418881#ent", "pos": [11, 12]}}
{"token": ["Ellagic", "acid", "EA", ")", ",", "tannic", "acid", "TA", ")", ",", "caffeic", "acid", "CA", ")", ",", "and", "ferulic", "acid", "C0015625#ent", "<e1>", ")", "offer", "considerable", "promise", "as", "C0085169#ent", "<e2>", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0085169", "name": "C0085169#ent", "pos": [25, 26]}}
{"token": ["Immunizing", "guinea", "pigs", "with", "subunit", "HSV", "glycoprotein", "vaccines", "favorably", "altered", "the", "clinical", "and", "virological", "course", "initial", "infection", "and", "substantially", "reduced", "the", "incidence", ",", "frequency", ",", "and", "C0720099#ent", "<e1>", "of", "recurrent", "C0019372#ent", "<e2>"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [30, 31]}}
{"token": ["Three", "patients", "had", "early", "life", "C0025289#ent", "<e1>", "and", "developed", "symptoms", "of", "C0039144#ent", "<e2>", "eight", ",", "21", ",", "and", "23", "years", "after", "the", "acute", "infection"], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039144", "name": "C0039144#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "C0064113#ent", "<e1>", "is", "suitable", "for", "treatment", "of", "a", "variety", "of", "C0026946#ent", "<e2>", "as", "aspergillosis", ",", "cryptococcosis", ",", "candidosis", "as", "well", "as", "non-European", "endemic", "mycoses", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [2, 3]}, "relation": "may_prevent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [12, 13]}}
{"token": ["We", "have", "tested", "the", "allele", "frequency", "C1416402#ent", "<e1>", "in", "128", "patients", "with", "insulin-dependent", "and", "125", "with", "non-insulin-dependent", "diabetes", "mellitus", "C3273872#ent", "<e2>", ")", "."], "h": {"id": "C1416402", "name": "C1416402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [19, 20]}}
{"token": ["Drospirenone", "is", "a", "compound", "closely", "resembling", "progesterone", ",", "but", "with", "the", "antimineralocorticoid", "and", "C0002842#ent", "<e1>", "properties", "of", "a", "related", "therapeutic", "agent", "the", "diuretic", ",", "C0003364#ent", "<e2>", "and", "androgen", "receptor", "antagonist", "17alpha-spironolactone", "."], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [24, 25]}}
{"token": ["To", "answer", "this", "question", "of", "clinical", "relevance", "4", "disease", "complexes", "been", "investigated", ":", "lupus", "erythematodes", "systemic", "affections", "by", "C0003862#ent", "<e1>", ",", "hepatitis", "and", "C0040147#ent", "<e2>", "."], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0040147", "name": "C0040147#ent", "pos": [23, 24]}}
{"token": ["C0036690#ent", "<e1>", "is", "the", "most", "important", "trigger", "for", "acute", "renal", "failure", "with", "C0015624#ent", "<e2>", "collapse", "in", "urine", "concentration"], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [12, 13]}}
{"token": ["The", "in", "vitro", "C1418482#ent", "<e1>", "response", "by", "C57BL/6", "mice", "utilized", "to", "determine", "if", "C3813548#ent", "<e2>", "could", "suppress", "the", "antibody", "response", "to", "a", "direct", "effect", "on", "the", "immune", "cells"], "h": {"id": "C1418482", "name": "C1418482#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3813548", "name": "C3813548#ent", "pos": [13, 14]}}
{"token": ["The", "five", "patients", "with", "C1291208#ent", "<e1>", "intolerance", "all", "had", "pre-existing", "C0426576#ent", "<e2>", "four", "of", "them", "had", "received", "treatment", "with", "cimetidine", "or", "omeprazol", "before", "inclusion", "into", "the", "study", "."], "h": {"id": "C1291208", "name": "C1291208#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [10, 11]}}
{"token": ["Genotype/phenotype", "analysis", "that", "all", "(", "21", "of", "21", ")", "patients", "with", "C0694895#ent", "<e1>", "deletions", "extending", "3", "'", "into", "the", "PKD1", "gene", "C3887499#ent", "<e2>"], "h": {"id": "C0694895", "name": "C0694895#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887499", "name": "C3887499#ent", "pos": [21, 22]}}
{"token": ["Pentobarbitone", ",", "C0031412#ent", "<e1>", ",", "diazepam", ",", "chlordiazepoxide", "and", "C0033218#ent", "<e2>", "had", "only", "minimal", "effects", "on", "current", "decay", "at", "concentrations", "which", "are", "highly", "effective", "in", "other", "preparations", "."], "h": {"id": "C0031412", "name": "C0031412#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033218", "name": "C0033218#ent", "pos": [9, 10]}}
{"token": ["Detailed", "fluorescence", "in", "situ", "hybridization", "real-time", "quantitative", "polymerase", "chain", "reaction", "analyses", "an", "amplified", "genomic", "segment", "approximately", "590", "kb", "containing", "only", "the", "C1417679#ent", "<e1>", "MYCN", "and", "C1424629#ent", "<e2>", "(", "v-myc", "myelocytomatosis", "viral-related", "oncogene", "neuroblastoma-derived", "opposite", "strand", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1424629", "name": "C1424629#ent", "pos": [25, 26]}}
{"token": ["The", "C0076456#ent", "<e1>", "and", "high", "dose", "laser", "groups", "greater", "neutrophil", "and", "C0148346#ent", "<e2>", "counts", "than", "in", "the", "control", "group", "suggesting", "a", "more", "beneficial", "effect", "for", "wound", "healing"], "h": {"id": "C0076456", "name": "C0076456#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0148346", "name": "C0148346#ent", "pos": [11, 12]}}
{"token": ["A", "description", "of", "the", "protein", "binding", "site", "generated", "using", "gaussian", "property", "fields", "like", "in", "C2362546#ent", "<e1>", "Similarity", "Analysis", "(", "C0795939#ent", "<e2>", ")", "."], "h": {"id": "C2362546", "name": "C2362546#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0795939", "name": "C0795939#ent", "pos": [19, 20]}}
{"token": ["The", "results", "obtained", "suggest", "that", "an", "impairment", "of", "the", "pressor", "response", "to", "C3887648#ent", "<e1>", "is", "not", "a", "general", "prerequisite", "for", "the", "C1516018#ent", "<e2>", "calcium", "antagonists"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1516018", "name": "C1516018#ent", "pos": [21, 22]}}
{"token": ["This", "study", "demonstrated", "that", "C0126174#ent", "<e1>", "and", "E-3174", "exert", "additional", "inhibitory", "action", "on", "cAMP", "C0031640#ent", "<e2>", "besides", "AII", "receptor", "antagonism", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [14, 15]}}
{"token": ["Several", "human", "C0751336#ent", "<e1>", "cardiomyopathies", "have", "previously", "been", "linked", "to", "mutations", "in", "the", "C1421222#ent", "<e2>"], "h": {"id": "C0751336", "name": "C0751336#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421222", "name": "C1421222#ent", "pos": [13, 14]}}
{"token": ["These", "C0003015#ent", "<e1>", "degradation", "of", "p53", "without", "affecting", "C0812222#ent", "<e2>", "the", "nuclear", "shuttling", "function", "of", "p53", "and", "MDM2", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [8, 9]}}
{"token": ["In", "this", "study", ",", "we", "have", "evaluated", "whether", "PAHs", "activate", "the", "C1414315#ent", "<e1>", "EGR-1", ")", "gene", "and", "bind", "to", "peroxisome", "proliferator-activated", "receptor", "alpha", "C2984537#ent", "<e2>", "and", "delta", "(", "PPAR", "beta/delta", ")", "in", "cell", "culture", "systems"], "h": {"id": "C1414315", "name": "C1414315#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2984537", "name": "C2984537#ent", "pos": [23, 24]}}
{"token": ["PET", "is", "used", "for", "characterizing", "brain", "disorders", "as", "C0002395#ent", "<e1>", "epilepsy", "and", "C0265122#ent", "<e2>", "as", "coronary", "artery", "disease", "myocardial", "viability"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0265122", "name": "C0265122#ent", "pos": [12, 13]}}
{"token": ["In", "vitro", "analysis", "of", "the", "response", "of", "human", "peripheral", "blood", "leucocytes", "to", "C2930490#ent", "<e1>", "may", "be", "a", "useful", "test", "in", "clinical", "trials", "C0991617#ent", "<e2>", "such", "as", "C2930490#ent", "<e1>", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2930490", "name": "C2930490#ent", "pos": [12, 13]}}
{"token": ["Three", "patients", "had", "C0549410#ent", "<e1>", "1", "patient", "had", "C0031117#ent", "<e2>", "1", "patient", "had", "G4", "gastrointestinal", "bleed", "and", "1", "patient", "had", "G3", "radiation", "enteritis"], "h": {"id": "C0549410", "name": "C0549410#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [8, 9]}}
{"token": ["In", "addition", "to", "the", "coding", "sequences", "the", "C2981723#ent", "<e1>", "and", "an", "N-terminal", "signal", "sequence", "the", "C0017337#ent", "<e2>", "contained", "a", "single", "intron", "in", "the", "nontranslated", "3'", "end"], "h": {"id": "C2981723", "name": "C2981723#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["We", "purified", "and", "characterized", "four", "mutants", "which", "produced", "highest", "C1333216#ent", "<e1>", "activity", ",", "i.e.", ",", "the", "Gln108", ",", "C3538783#ent", "<e2>", ",", "Cys108", ",", "and", "Ala108", "mutants", "."], "h": {"id": "C1333216", "name": "C1333216#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538783", "name": "C3538783#ent", "pos": [18, 19]}}
{"token": ["The", "C0031727#ent", "<e1>", "a", "distinct", "bias", "for", "S-MCT", ",", "while", "C0012888#ent", "<e2>", "exclusively", "incorporate", "the", "North", "5'-triphosphate", "N-MCT-TP", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012888", "name": "C0012888#ent", "pos": [10, 11]}}
{"token": ["C0162296#ent", "<e1>", "was", "the", "main", "symptom", "and", "was", "often", "accompanied", "with", "C0231528#ent", "<e2>", ";", "a", "polyalgic", "syndrome", "was", "seen", "in", "some", "patients", "."], "h": {"id": "C0162296", "name": "C0162296#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [11, 12]}}
{"token": ["C1739021#ent", "<e1>", "and", "CDC25B", "cooperate", "with", "C0079972#ent", "<e2>", "or", "loss", "of", "Rb1", "in", "the", "oncogenic", "transformation", "rodent", "fibroblasts", "."], "h": {"id": "C1739021", "name": "C1739021#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079972", "name": "C0079972#ent", "pos": [6, 7]}}
{"token": ["The", "absence", "of", "charged", "residues", "in", "oligosaccharide", "chains", "variability", "in", "the", "polypeptide", "subunits", "the", "charge", "forms", "of", "C0015278#ent", "<e1>", "that", "charge", "heterogeneity", "results", "from", "differences", "in", "the", "C0175168#ent", "<e2>", "the", "charge", "forms"], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [27, 28]}}
{"token": ["This", "syndrome", "was", "caused", "by", "viruses", "(", "B", "and", "non-B", "hepatitis", "C1318711#ent", "<e1>", "in", "23", "patients", ",", "C0860207#ent", "<e2>", "6", ",", "Wilson's", "disease", "hepatolenticular", "degeneration", "in", "3", ",", "and", "industrial", "poisons", "2", "."], "h": {"id": "C1318711", "name": "C1318711#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0860207", "name": "C0860207#ent", "pos": [17, 18]}}
{"token": ["Recombinant", "human", "C3538758#ent", "<e1>", ",", "produced", "by", "co-expressing", "alpha-globin", "and", "C2827561#ent", "<e2>", "the", "yeast", "Saccharomyces", "cerevisiae", "has", "been", "characterised", "extensively", "both", "physically", "and", "functionally", "."], "h": {"id": "C3538758", "name": "C3538758#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2827561", "name": "C2827561#ent", "pos": [10, 11]}}
{"token": ["Lower", "rates", "reported", "with", "some", "newer", "C0991617#ent", "<e1>", "such", "as", "C0168388#ent", "<e2>", "and", "bupropion", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0168388", "name": "C0168388#ent", "pos": [10, 11]}}
{"token": ["Complex", "epithelial", "keratins", "scant", ":", "C1416717#ent", "<e1>", "in", "one", "case", "and", "C1416728#ent", "<e2>", "in", "two", "cases", "."], "h": {"id": "C1416717", "name": "C1416717#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416728", "name": "C1416728#ent", "pos": [11, 12]}}
{"token": ["C1335262#ent", "<e1>", "is", "a", "460", "kDa", "C0072402#ent", "<e2>", "is", "activated", "by", "direct", "interaction", "with", "DNA", "."], "h": {"id": "C1335262", "name": "C1335262#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [6, 7]}}
{"token": ["Eight", "of", "the", "thirteen", "identified", "FA", "genes", "encode", "C0599220#ent", "<e1>", "of", "a", "nuclear", "FA", "complex", "that", "monoubiquitinates", "FANCD2", "and", "C1836861#ent", "<e2>", "to", "maintain", "genomic", "stability", "response", "to", "replication", "stress"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1836861", "name": "C1836861#ent", "pos": [19, 20]}}
{"token": ["More", "striking", "associations", "between", "incomplete", "IM", "and", "salted", "food", "intake", "observed", "among", "subjects", "with", "genotypes", "of", "C1738886#ent", "<e1>", "null", ",", "GSTT1", "non-null", "and", "C0010763#ent", "<e2>", "c1/c1", "."], "h": {"id": "C1738886", "name": "C1738886#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [23, 24]}}
{"token": ["In", "a", "prospective", "clinical", "trial", "we", "tested", "the", "effects", "of", "coadministration", "of", "tamoxifen", "and", "the", "C2911696#ent", "<e1>", "paroxetine", ",", "an", "inhibitor", "of", "C1332830#ent", "<e2>", ",", "on", "tamoxifen", "metabolism"], "h": {"id": "C2911696", "name": "C2911696#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332830", "name": "C1332830#ent", "pos": [22, 23]}}
{"token": ["The", "selective", "C2911696#ent", "<e1>", "SSRIs", ")", "are", "known", "to", "inhibit", "C1332830#ent", "<e2>", "."], "h": {"id": "C2911696", "name": "C2911696#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332830", "name": "C1332830#ent", "pos": [10, 11]}}
{"token": ["Following", "C3541397#ent", "<e1>", "feeding", ",", "only", "the", "heparitins", "and", "multisulfated", "C0020197#ent", "<e2>", "were", "present", "in", "the", "small", "intestine", "and", "no", "heparin", "was", "found", "."], "h": {"id": "C3541397", "name": "C3541397#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020197", "name": "C0020197#ent", "pos": [10, 11]}}
{"token": ["Experimentally", ",", "halothane", "and", "enflurane", "have", "direct", "cardiac", "inhibitory", "similar", "to", "verapamil", "and", "diltiazem", ",", "whereas", "isoflurane's", "properties", "seem", "closer", "to", "the", "C0012315#ent", "<e1>", "(", "nifedipine", "and", "C0028005#ent", "<e2>", ")", "."], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [22, 23]}, "relation": "chemical_structure_of", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [27, 28]}}
{"token": ["Of", "the", "calcium-channel", "blockers", "the", "C0012315#ent", "<e1>", "nifedipine", "and", "C0028005#ent", "<e2>", "are", "recommended", "as", "first-line", "agents", "hypertensive", "emergencies", "urgencies", "because", "of", "their", "peripheral", "arteriolar", "bed", "selectivity", "and", "their", "pharmacologic", "and", "kinetic", "profiles"], "h": {"id": "C0012315", "name": "C0012315#ent", "pos": [5, 6]}, "relation": "chemical_structure_of", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [9, 10]}}
{"token": ["Renal", "failure", "cases", "of", "lymphoma", "is", "secondary", "to", "ureteral", "obstruction", "C0020437#ent", "<e1>", ",", "urate", "nephropathy", "gammopathy", "or", "immunologically", "mediated", "C0027720#ent", "<e2>", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027720", "name": "C0027720#ent", "pos": [19, 20]}}
{"token": ["Because", "of", "its", "physical", "location", "imprinting", "pattern", ",", "C1422052#ent", "<e1>", "was", "considered", "to", "be", "a", "candidate", "C0017337#ent", "<e2>", "for", "chromosome", "15-associated", "autism", "."], "h": {"id": "C1422052", "name": "C1422052#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["C0017160#ent", "<e1>", "the", "commonest", "C0017178#ent", "<e2>", "children", "."], "h": {"id": "C0017160", "name": "C0017160#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [4, 5]}}
{"token": ["The", "correlation", "between", "the", "degree", "of", "C0017152#ent", "<e1>", "and", "the", "labeling", "indices", "C0293352#ent", "<e2>", "and", "fundic", "mucosa", "also", "statistically", "significant"], "h": {"id": "C0017152", "name": "C0017152#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0293352", "name": "C0293352#ent", "pos": [12, 13]}}
{"token": ["B", "cells", "the", "follicular", "mantles", "acquired", "C1704467#ent", "<e1>", "after", "12", "wk", "in", "CV", "rats", ",", "whereas", "B", "cells", "the", "C1414531#ent", "<e2>", "did", "not", "express", "C1704467#ent", "<e1>", "at", "a", "substantial", "level", "throughout", "the", "experimental", "period"], "h": {"id": "C1414531", "name": "C1414531#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [6, 7]}}
{"token": ["Craniofacial", "surgery", "a", "new", "field", "of", "endeavor", "in", "plastic", "surgery", "involving", "new", "techniques", "that", "can", "be", "used", "to", "treat", "C0015300#ent", "<e1>", "of", "Graves'", "disease", "the", "facial", "deformities", "from", "gigantism", "and", "C0001206#ent", "<e2>", "."], "h": {"id": "C0015300", "name": "C0015300#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [30, 31]}}
{"token": ["Hyperammonemia", "resulting", "from", "inherited", "urea", "cycle", "deficiencies", "or", "C0162557#ent", "<e1>", "results", "in", "severe", "central", "nervous", "system", "dysfunction", "brain", "edema", "C4048158#ent", "<e2>", "and", "coma", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [19, 20]}}
{"token": ["It", "has", "been", "proposed", "that", "a", "specific", "C1415975#ent", "<e1>", "response", "contributes", "to", "the", "immunopathology", "of", "acute", "respiratory", "syncytial", "virus", "RSV", ")", "C0006271#ent", "<e2>", "but", "previous", "work", "has", "been", "difficult", "to", "replicate", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006271", "name": "C0006271#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "we", "investigated", "the", "P-glycoprotein-mediated", "transport", "of", "propranolol", ",", "metoprolol", ",", "C0053799#ent", "<e1>", ",", "carvedilol", "and", "C0037707#ent", "<e2>", "in", "P-glycoprotein-expressing", "Caco-2", "monolayers", "and", "inhibition", "of", "P-glycoprotein-mediated", "digoxin", "transport", "by", "the", "beta-adrenoceptor", "antagonists"], "h": {"id": "C0053799", "name": "C0053799#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0037707", "name": "C0037707#ent", "pos": [17, 18]}}
{"token": ["Chediak", "-", "C0007965#ent", "<e1>", "CHS", ")", "is", "a", "rare", ",", "primary", "Immunodeficiency", "disorder", "an", "C3899988#ent", "<e2>", "AR", ")", "inheritance", "and", "characterized", "by", "recurrent", "infection", "partial", "occulocutaneous", "albinism", "an", "accelerated", "phase", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [14, 15]}}
{"token": ["The", "role", "of", "the", "long", "loop", "connecting", "beta-strands", "F5", "and", "F6", "(", "21", "C3539947#ent", "<e1>", "Pro302-Leu-Asp-Arg-Thr-Lys-Ser-Pro-Leu-Ser-Leu-Gly-Arg-Gly-Ser-Ala-Arg-Ala-Ala-Lys-Glu322", ")", "present", "in", "C1450094#ent", "<e2>", "RgDAAO", ")", "was", "investigated", "by", "site-directed", "mutagenesis"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1450094", "name": "C1450094#ent", "pos": [19, 20]}}
{"token": ["We", "postulated", "that", "human", "lung", "fibroblasts", "produce", "interleukin-8", "(", "C1366571#ent", "<e1>", ")", "in", "response", "to", "C1705889#ent", "<e2>", "stimulation", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705889", "name": "C1705889#ent", "pos": [15, 16]}}
{"token": ["The", "lateral", "mobility", "C1539478#ent", "<e1>", "is", "relatively", "restricted", "compared", "with", "C1335209#ent", "<e2>", "."], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335209", "name": "C1335209#ent", "pos": [10, 11]}}
{"token": ["Primary", "prevention", "studies", "beta-blockers", "reduce", "the", "incidence", "of", "C0007820#ent", "<e1>", "coronary", "heart", "disease", "younger", "patients", "but", "they", "appear", "less", "effective", "than", "C0012798#ent", "<e2>", "in", "the", "elderly", "."], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [21, 22]}}
{"token": ["Furthermore", ",", "C1513344#ent", "<e1>", "knockdown", "of", "Erk1", "could", "restore", "activation", "of", "C0164786#ent", "<e2>", "and", "downregulate", "mTOR", "."], "h": {"id": "C1513344", "name": "C1513344#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [11, 12]}}
{"token": ["Chronic", "actinic", "dermatitis", "defined", "clinically", "by", "C0262975#ent", "<e1>", "skin", "exposed", "to", "sun", ",", "histologically", "by", "C0262984#ent", "<e2>", "and", "photobiologically", "by", "experimental", "provocation", "C0262984#ent", "<e2>", "UV-B", "and", "often", "also", "longer", "wavelengths", "in", "the", "absence", "of", "a", "photoallergen", "."], "h": {"id": "C0262975", "name": "C0262975#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0262984", "name": "C0262984#ent", "pos": [15, 16]}}
{"token": ["Both", "types", "of", "monoliths", "with", "immobilized", "C0053413#ent", "<e1>", "exhibited", "strong", "affinity", "toward", "mannose-binding", "proteins", "C1417057#ent", "<e2>", ")", "such", "as", "the", "plant", "lectins", "concanavalin", "A", "Lens", "culinaris", "agglutinin", "a", "mammalian", "lectin", "e.g.", "rabbit", "serum", "mannose-binding", "protein", "."], "h": {"id": "C0053413", "name": "C0053413#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417057", "name": "C1417057#ent", "pos": [14, 15]}}
{"token": ["The", "ER", "stress", "genes", "ERdj5", ",", "ERp57", ",", "GRP78", ",", "calreticulin", "and", "C1413107#ent", "<e1>", "were", "induced", "in", "neuroectodermal", "tumour", "cells", "C0060197#ent", "<e2>", "."], "h": {"id": "C1413107", "name": "C1413107#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0060197", "name": "C0060197#ent", "pos": [20, 21]}}
{"token": ["C0242957#ent", "<e1>", "binding", "to", "peptides", "containing", "the", "Src", "homology", "2", "domain", "Grb2", "or", "C1418577#ent", "<e2>", "and", "the", "phosphotyrosine", "binding", "domain", "Shc", "varied", "according", "to", "the", "mode", "of", "receptor", "activation"], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418577", "name": "C1418577#ent", "pos": [13, 14]}}
{"token": ["By", "participating", "in", "the", "design", "and", "implementation", "of", "clinical", "trials", "gene", "therapy", "the", "neurologist", "may", "reduce", "the", "intense", "C1705581#ent", "<e1>", "that", "several", "C0027765#ent", "<e2>", "on", "children", "and", "their", "families", "."], "h": {"id": "C1705581", "name": "C1705581#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [22, 23]}}
{"token": ["On", "the", "basis", "of", "its", "predicted", "homology", "to", "human", "C1367342#ent", "<e1>", "hTERT", ")", ",", "a", "cDNA", "for", "Arabidopsis", "thaliana", "C0754515#ent", "<e2>", "(", "AtTERT", ")", "has", "now", "been", "isolated", "from", "cultured", "cells"], "h": {"id": "C1367342", "name": "C1367342#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0754515", "name": "C0754515#ent", "pos": [19, 20]}}
{"token": ["The", "interaction", "of", "lisuride", "(", "Lysenyl", ",", "Spofa", ")", ",", "an", "C0870507#ent", "<e1>", "with", "serotonergic", "and", "dopaminergic", "receptors", "with", "C1382029#ent", "<e2>", "studied", "in", "homogenates", "of", "rabbit", "brain", "."], "h": {"id": "C0870507", "name": "C0870507#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [19, 20]}}
{"token": ["C0003078#ent", "<e1>", "is", "a", "condition", "in", "which", "the", "two", "C0235267#ent", "<e2>", "perceive", "images", "of", "different", "size", "or", "shape", ",", "causing", "a", "variety", "of", "visual", "symptoms", "including", "asthenopia", "."], "h": {"id": "C0003078", "name": "C0003078#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [9, 10]}}
{"token": ["The", "C0003078#ent", "<e1>", "derived", "from", "the", "meridional", "magnification", "effects", "of", "the", "two", "C0235267#ent", "<e2>", "on", "a", "circular", "object", "represents", "the", "aniseikonic", "ratio", "all", "meridians", "."], "h": {"id": "C0003078", "name": "C0003078#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [12, 13]}}
{"token": ["Because", "of", "its", "inhibitory", "action", "on", "the", "thrombin-mediated", "activation", "of", "factor", "VIII", "C1451270#ent", "<e1>", "prolonged", "the", "lag", "phase", "the", "factor", "X", "complex", "that", "consists", "of", "C0015494#ent", "<e2>", "factor", "VIIIa"], "h": {"id": "C1451270", "name": "C1451270#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015494", "name": "C0015494#ent", "pos": [25, 26]}}
{"token": ["The", "present", "study", "underlines", "the", "importance", "of", "sodium", "phenylacetate", "NaPA", ")", ",", "a", "drug", "approved", "for", "C0154246#ent", "<e1>", "in", "inhibiting", "the", "C0012634#ent", "<e2>", "adoptively", "transferred", "EAE", "in", "female", "SJL/J", "mice", "at", "multiple", "steps"], "h": {"id": "C0154246", "name": "C0154246#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [21, 22]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "whether", "C0406810#ent", "<e1>", "could", "enhance", "the", "C0079083#ent", "<e2>", "antitumor", "activity", "a", "human", "osteosarcoma", "xenograft", "model"], "h": {"id": "C0406810", "name": "C0406810#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [14, 15]}}
{"token": ["These", "oncoproteins", "act", "as", "aberrant", "transcription", "factors", "to", "the", "fusion", "of", "an", "C1705691#ent", "<e1>", "DNA", "binding", "domain", "a", "highly", "potent", "EWS", "(", "or", "C1414860#ent", "<e2>", ")", "transactivation", "domain"], "h": {"id": "C1705691", "name": "C1705691#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414860", "name": "C1414860#ent", "pos": [23, 24]}}
{"token": ["There", "is", "a", "significant", "correlation", "between", "in", "situ", "hybridization", "northern", "blot", "analysis", "C3273406#ent", "<e1>", "mRNA", "in", "both", "the", "C0017547#ent", "<e2>", "cell", "tumor", "bone", "and", "the", "osteosarcoma", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [18, 19]}}
{"token": ["The", "constituent", "polypeptide", "chains", "I", ",", "C3273406#ent", "<e1>", ",", "III", "and", "IV", "of", "the", "C0017547#ent", "<e2>", "extracellular", "haemoglobin", "of", "the", "oligochaete", "Lumbricus", "terrestris", "isolated", "by", "mono", "Q", "ion-exchange", "chromatography", "C8", "reverse-phase", "chromatography"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "microarray", "analysis", "C3540822#ent", "<e1>", "ETV5", ",", "ZNF133", "and", "CEBPG", "as", "possible", "candidate", "C1417679#ent", "<e2>", "involved", "in", "IFN-gamma-mediated", "repression", "of", "S100A4", "."], "h": {"id": "C3540822", "name": "C3540822#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}}
{"token": ["Because", "eukaryotic", "genes", "packaged", "as", "nucleosomes", "that", "contribute", "to", "both", "chromatin", "organization", "transcriptional", "control", "we", "functionally", "examined", "the", "activity", "of", "C3539565#ent", "<e1>", "promoter", "constructs", "within", "a", "C0008546#ent", "<e2>", "context", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [26, 27]}}
{"token": ["C0133930#ent", "<e1>", "an", "important", "downstream", "target", "of", "C0044602#ent", "<e2>", "is", "one", "of", "the", "major", "survival", "factors", "mammalian", "cells"], "h": {"id": "C0133930", "name": "C0133930#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [7, 8]}}
{"token": ["AGE", "induced", "C1419227#ent", "<e1>", "activation", "and", "increased", "phosphorylation", "of", "C1704984#ent", "<e2>", "at", "serine-307", "residues", ",", "JNK", ",", "c-JUN", ",", "and", "IkappaB", "kinase", "association", "with", "decreased", "IkappaB", "levels", "in", "Hep3B", "cells", "."], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704984", "name": "C1704984#ent", "pos": [9, 10]}}
{"token": ["Empirical", "demonstration", "of", "amelioration", "of", "C0007286#ent", "<e1>", "symptoms", "by", "means", "of", "surface", "electromyography", "C1419955#ent", "<e2>", ")", "retraining", "of", "dysfunctional", "neck", "muscle", "patterns", "is", "reviewed", "as", "support", "for", "the", "hypothesized", "link", "."], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419955", "name": "C1419955#ent", "pos": [13, 14]}}
{"token": ["Vulval", "vestibulitis", "a", "condition", "characterized", "by", "the", "sudden", "onset", "a", "C0239377#ent", "<e1>", "burning", "sensation", ",", "hyperalgesia", ",", "mechanical", "allodynia", "and", "occasionally", "C0033775#ent", "<e2>", ",", "localized", "to", "the", "region", "of", "the", "vulval", "vestibulus"], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033775", "name": "C0033775#ent", "pos": [21, 22]}}
{"token": ["Hypopituitarism", "during", "pregnancy", "may", "be", "the", "result", "of", "C0271560#ent", "<e1>", "antepartum", "pituitary", "necrosis", "and", "in", "the", "postpartum", "period", "be", "because", "of", "postpartum", "hemorrhage", "C0271558#ent", "<e2>"], "h": {"id": "C0271560", "name": "C0271560#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0271558", "name": "C0271558#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "report", "alterations", "of", "platelet-derived", "growth", "factor", "receptor", "alpha", "PDGFR-alpha", ")", "and", "beta", "(", "PDGFR-beta", ")", "and", "C1522575#ent", "<e1>", "VEGF", ")", "expression", "patterns", "in", "the", "progressive", "clinical", "stages", "C0042485#ent", "<e2>", "CVI", ")", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0042485", "name": "C0042485#ent", "pos": [30, 31]}}
{"token": ["Triggering", "receptor", "expressed", "on", "myeloid", "cells-1", "TREM-1", ")", "is", "a", "member", "of", "a", "new", "family", "of", "myeloid", "receptors", "encoded", "by", "a", "C1418864#ent", "<e1>", "to", "the", "C0024518#ent", "<e2>", "."], "h": {"id": "C1418864", "name": "C1418864#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [25, 26]}}
{"token": ["To", "report", "the", "cases", "of", "four", "patients", "with", "C4288963#ent", "<e1>", "experienced", "clinical", "features", "that", "are", "virtually", "identical", "to", "C0042170#ent", "<e2>", "VKH", ")", "."], "h": {"id": "C4288963", "name": "C4288963#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042170", "name": "C0042170#ent", "pos": [18, 19]}}
{"token": ["Rheumatic", "fever", "a", "preventable", "C0022661#ent", "<e1>", "by", "group", "A", "beta-haemolytic", "streptococcal", "GABHS", ")", "C0031350#ent", "<e2>", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [13, 14]}}
{"token": ["C4288963#ent", "<e1>", "stimulates", "the", "expression", "of", "C1417679#ent", "<e2>", "related", "to", "lipogenesis", "."], "h": {"id": "C4288963", "name": "C4288963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}}
{"token": ["In", "this", "Swedish", "nation-wide", "longitudinal", "study", "wanted", "to", "evaluate", "long-term", "survival", "after", "C0027051#ent", "<e1>", "in", "relation", "to", "socioeconomic", "position", "C1418664#ent", "<e2>", ")", "and", "use", "of", "revascularization", "."], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418664", "name": "C1418664#ent", "pos": [19, 20]}}
{"token": ["C0002963#ent", "<e1>", "using", "ergonovine", "during", "the", "second", "coronary", "angiography", "could", "not", "provoke", "C3812627#ent", "<e2>", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3812627", "name": "C3812627#ent", "pos": [12, 13]}}
{"token": ["In", "order", "to", "determine", "whether", "local", "synthesis", "C2936882#ent", "<e1>", "occurred", "in", "human", "colonic", "cancer", "cells", "two", "colorectal", "cancer", "cell", "lines", "C3812701#ent", "<e2>", "and", "HCT116", ",", "were", "evaluated", "for", "gene", "expression", "enzyme", "activity", "cytochrome", "P450", "aromatase"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3812701", "name": "C3812701#ent", "pos": [20, 21]}}
{"token": ["C1413930#ent", "<e1>", ",", "biglycan", ",", "and", "fibromodulin", "are", "closely", "related", "in", "C0175168#ent", "<e2>", "differ", "in", "glycosaminoglycan", "composition", "and", "function", "."], "h": {"id": "C1413930", "name": "C1413930#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [11, 12]}}
{"token": ["Of", "these", ",", "only", "C0017154#ent", "<e1>", "pernicious", "anaemia", "gastric", "stumps", "and", "certain", "types", "of", "C0236048#ent", "<e2>", "now", "be", "regarded", "as", "having", "any", "really", "significant", "malignant", "potential", "."], "h": {"id": "C0017154", "name": "C0017154#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0236048", "name": "C0236048#ent", "pos": [14, 15]}}
{"token": ["Administration", "of", "both", "C3811061#ent", "<e1>", "and", "C1413904#ent", "<e2>", "significantly", "reduced", "the", "enhancements", "by", "C3811061#ent", "<e1>", "of", "gastric", "carcinogenesis", "ODC", "activity", "of", "the", "antral", "wall", "the", "labeling", "index", "antral", "epithelial", "cells"], "h": {"id": "C1413904", "name": "C1413904#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3811061", "name": "C3811061#ent", "pos": [3, 4]}}
{"token": ["In", "this", "study", ",", "we", "identified", "C1332818#ent", "<e1>", "as", "a", "growth", "hormone", "C0079429#ent", "<e2>", "in", "HepG2", "hepatoma", "cells"], "h": {"id": "C1332818", "name": "C1332818#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}}
{"token": ["Inhibitors", "of", "both", "phosphatidylinositol-3-kinase", "(", "PI3-kinase", ")", "and", "MAPK/ERK", "(", "C0173879#ent", "<e1>", "activation", "inhibit", "C0022614#ent", "<e2>", "receptor-dependent", "long-term", "potentiation", "LTP", ")", "."], "h": {"id": "C0173879", "name": "C0173879#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [14, 15]}}
{"token": ["The", "developmental", "patterns", "severe", "C0042166#ent", "<e1>", "induced", "by", "C1419385#ent", "<e2>", "or", "opsin", "were", "histologically", "evaluated", "and", "appear", "to", "be", "similar", "."], "h": {"id": "C0042166", "name": "C0042166#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [8, 9]}}
{"token": ["Overuse", "can", "result", "in", "C0039520#ent", "<e1>", "the", "wrist", "and", "in", "synovitis", "with", "or", "without", "C0263912#ent", "<e2>", "of", "the", "flexor", "or", "extensor", "tendons", "the", "digitis", "or", "ruptures", "of", "the", "annular", "and", "cruciform", "pulleys", "."], "h": {"id": "C0039520", "name": "C0039520#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0263912", "name": "C0263912#ent", "pos": [14, 15]}}
{"token": ["The", "study", "cohorts", "676", "patients", "with", "C0151449#ent", "<e1>", "709", "with", "secondary", "C1527336#ent", "<e2>", "and", "9,469", "with", "rheumatoid", "arthritis", "identified", "from", "the", "Finnish", "hospitals", "national", "discharge", "register", "."], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [11, 12]}}
{"token": ["Hereditary", "tyrosinemia", "type", "1", "an", "autosomal", "recessive", "disease", "by", "a", "deficiency", "of", "the", "last", "C0027203#ent", "<e1>", "in", "the", "catabolic", "pathway", "tyrosine", ",", "C0060828#ent", "<e2>", "FAH", ")", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0060828", "name": "C0060828#ent", "pos": [22, 23]}}
{"token": ["In", "this", "report", ",", "we", "have", "developed", "an", "in", "vitro", "assay", "to", "study", "the", "binding", "of", "bacterially", "expressed", "C0017837#ent", "<e1>", "v-Crk", "and", "its", "cellular", "homolog", "C0084216#ent", "<e2>", ",", "to", "the", "phosphorylated", "epidermal", "growth", "factor", "receptor", "EGFR", ")", "."], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0084216", "name": "C0084216#ent", "pos": [25, 26]}}
{"token": ["Three", "patient", "groups", "sampled", ":", "cluster", "A", "+", "B", "C1271398#ent", "<e1>", ",", "cluster", "C", "C1271398#ent", "<e1>", "and", "C0012634#ent", "<e1>"], "h": {"id": "C1271398", "name": "C1271398#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [17, 18]}}
{"token": ["The", "other", "C1706112#ent", "<e1>", "encodes", "a", "different", "C0052179#ent", "<e2>", ",", "having", "cysteine", ",", "arginine", ",", "and", "arginine", "at", "each", "of", "the", "above", "positions", ",", "respectively", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0052179", "name": "C0052179#ent", "pos": [7, 8]}}
{"token": ["Ceramide", "was", "found", "to", "bind", "specifically", "to", "and", "activate", "C0139030#ent", "<e1>", "leading", "to", "subsequent", "activation", "of", "the", "C4082284#ent", "<e2>", "ERK", ")", "module", "in", "mesangial", "cells"], "h": {"id": "C0139030", "name": "C0139030#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [17, 18]}}
{"token": ["Recently", ",", "mutations", "in", "lamin", "A/C", "LMNA", ")", "and", "C0025543#ent", "<e1>", "ZMPSTE24", ")", ",", "involved", "in", "post-translational", "processing", "C0291592#ent", "<e2>", "mature", "lamin", "A", "have", "been", "identified", "in", "MAD", "kindreds", "."], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0291592", "name": "C0291592#ent", "pos": [18, 19]}}
{"token": ["The", "secondary", "laminopathies", "are", "due", "to", "mutations", "in", "ZMPSTE24", "gene", "encodes", "for", "a", "C0025543#ent", "<e1>", "in", "processing", "of", "C0291592#ent", "<e2>", "mature", "lamin", "A", "cause", "mandibuloacral", "dysplasia", "restrictive", "dermopathy"], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0291592", "name": "C0291592#ent", "pos": [18, 19]}}
{"token": ["There", "was", "an", "appreciable", "increase", "in", "abnormally", "phosphorylated", "C2697954#ent", "<e1>", "in", "an", "C0002395#ent", "<e2>", "brain", "with", "severe", "neurofibrillary", "degeneration", "whereas", "the", "normal", "C2697954#ent", "<e1>", "levels", "were", "increased", "only", "slightly", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C2697954", "name": "C2697954#ent", "pos": [8, 9]}}
{"token": ["Recruitment", "requires", "the", "transcriptional", "activator", "Hac1", ",", "which", "is", "produced", "upon", "induction", "of", "the", "UPR", ",", "and", "is", "C0669365#ent", "<e1>", "in", "a", "strain", "lacking", "C3537219#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3537219", "name": "C3537219#ent", "pos": [24, 25]}}
{"token": ["ICRE-dependent", "transcription", "C0669365#ent", "<e1>", "in", "the", "absence", "of", "the", "C3537219#ent", "<e2>", "repressor", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3537219", "name": "C3537219#ent", "pos": [9, 10]}}
{"token": ["Results", "of", "long-term", "administration", "of", "L-threo-3,4-dihydroxyphenylserine", "(", "L-DOPS", ")", ",", "a", "synthetic", "precursor", "C3887648#ent", "<e1>", ",", "in", "a", "patient", "with", "freezing", "gait", "pure", "C0085623#ent", "<e2>", "are", "reported", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085623", "name": "C0085623#ent", "pos": [23, 24]}}
{"token": ["Hypertrophic", "(", "HCM", ")", "and", "dilated", "(", "DCM", ")", "C0007193#ent", "<e1>", "result", "from", "sarcomeric", "protein", "mutations", ",", "including", "cardiac", "troponin", "T", "C3538782#ent", "<e2>", ",", "TNNT2", ")", "."], "h": {"id": "C0007193", "name": "C0007193#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538782", "name": "C3538782#ent", "pos": [21, 22]}}
{"token": ["The", "neurotensin-induced", "secretion", "was", "inhibited", "by", "SCH23390", ",", "a", "C0178601#ent", "<e1>", "but", "not", "by", "domperidone", ",", "phentolamine", ",", "propranolol", ",", "C1161352#ent", "<e2>", ",", "cimetidine", ",", "or", "L-364,718", ",", "a", "CCK", "antagonist", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [20, 21]}}
{"token": ["This", "study", "examined", "the", "retention", ",", "localization", ",", "and", "C1539479#ent", "<e1>", "of", "endotracheally", "instilled", "C0699918#ent", "<e2>", "using", "125Iodine", "labeled", "enzyme", "and", "immunoperoxidase", "histochemistry"], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [14, 15]}}
{"token": ["DNA", "sequence", "analysis", "that", "there", "were", "two", "transcriptional", "terminators", "the", "3", "'", "end", "of", "this", "C0022895#ent", "<e1>", "(", "downstream", "of", "C3273411#ent", "<e2>", "and", "ung", ")", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3273411", "name": "C3273411#ent", "pos": [20, 21]}}
{"token": ["Citrobacter", "species", "Gram-negative", "rods", "are", "best", "known", "for", "their", "propensity", "to", "cause", "neonatal", "meningitis", ",", "C1455718#ent", "<e1>", "and", "concomitant", "C1510428#ent", "<e2>"], "h": {"id": "C1455718", "name": "C1455718#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1510428", "name": "C1510428#ent", "pos": [19, 20]}}
{"token": ["The", "pathogenesis", "of", "familial", "portuguese", "C0206247#ent", "<e1>", "a", "form", "of", "C0598589#ent", "<e2>", "at", "present", "uncertain", "."], "h": {"id": "C0206247", "name": "C0206247#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0598589", "name": "C0598589#ent", "pos": [10, 11]}}
{"token": ["This", "was", "accompanied", "by", "increased", "expression", "of", "Ube2D1", "and", "SKP1A", ",", "an", "C0084913#ent", "<e1>", "a", "subunit", "of", "the", "C0077678#ent", "<e2>", "the", "Skp1/Cul1/F-box", "protein", "SCF", ")", "family", ",", "respectively", "."], "h": {"id": "C0084913", "name": "C0084913#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [18, 19]}}
{"token": ["An", "C0084913#ent", "<e1>", "Rad6", ",", "working", "with", "an", "C0077678#ent", "<e2>", "catalyzes", "monoubiquitylation", "of", "histone", "H2B", "a", "C-terminal", "lysine", "residue", "."], "h": {"id": "C0084913", "name": "C0084913#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [8, 9]}}
{"token": ["We", "also", "demonstrate", "that", "the", "C1709402#ent", "<e1>", "Akt", "is", "required", "for", "Met-triggered", "C0812222#ent", "<e2>", "upregulation", ",", "in", "addition", "to", "being", "necessary", "for", "the", "nuclear", "translocation", "C0812222#ent", "<e2>", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", "to", "C0162745#ent", "<e1>", "crab", "protease", "a", "good", "C1335528#ent", "<e2>", "of", "degrading", "a", "variety", "of", "polypeptide", "and", "synthetic", "low", "molecular", "weight", "substrates", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335528", "name": "C1335528#ent", "pos": [9, 10]}}
{"token": ["Other", "members", "of", "the", "C0076499#ent", "<e1>", "class", ",", "including", "sulfomycin", ",", "sporangiomycin", ",", "C0074574#ent", "<e2>", "and", "taitomycin", ",", "prevented", "lactic", "acidosis", "a", "manner", "similar", "to", "C0076499#ent", "<e1>", "."], "h": {"id": "C0076499", "name": "C0076499#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0074574", "name": "C0074574#ent", "pos": [13, 14]}}
{"token": ["Database", "searching", "demonstrates", "that", "some", "fish", "C0242965#ent", "<e1>", "contain", "multiple", "Cox-1", "or", "C1565860#ent", "<e2>", "cyclooxygenase", "genes", "suggesting", "alternate", "duplication", "and", "retention", "of", "this", "gene", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [12, 13]}}
{"token": ["C0250759#ent", "<e1>", "is", "implicated", "in", "fragile", "X", "mental", "retardation", "C0270921#ent", "<e2>", "and", "ataxia", "type", "1"], "h": {"id": "C0250759", "name": "C0250759#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270921", "name": "C0270921#ent", "pos": [9, 10]}}
{"token": ["Quantitative", "reverse", "transcriptase", "polymerase", "chain", "reaction", "analysis", "hepatic", "genes", "cytochrome", "p450", "3A29", "albumin", ",", "C1415119#ent", "<e1>", "alpha-1", "antitrypsin", "and", "carbamoyl-phosphate", "synthetase", "but", "also", "de-differentiation", "marker", "C0017837#ent", "<e2>", "stable", "messenger", "ribonucleic", "acid", "mRNA", ")", "levels", "from", "day", "1", "to", "5", "."], "h": {"id": "C1415119", "name": "C1415119#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [25, 26]}}
{"token": ["To", "further", "study", "C0525678#ent", "<e1>", "physiology", ",", "transgenic", "mice", "the", "human", "C1419338#ent", "<e2>", "produced", "by", "microinjection", "and", "were", "screened", "by", "PCR", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419338", "name": "C1419338#ent", "pos": [11, 12]}}
{"token": ["Renin", "is", "a", "rate-limiting", "enzyme", "for", "activity", "of", "the", "circulating", "renin-angiotensin", "system", "C0525678#ent", "<e1>", ")", "and", "expression", "of", "the", "C1419338#ent", "<e2>", "regulated", "by", "a", "variety", "of", "stimuli", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419338", "name": "C1419338#ent", "pos": [19, 20]}}
{"token": ["We", "determined", "whether", "gene", "polymorphisms", "associated", "with", "thrombophilia", "and", "C0042373#ent", "<e1>", "etiologic", "factors", "involved", "in", "the", "pathogenesis", "of", "C2984583#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2984583", "name": "C2984583#ent", "pos": [18, 19]}}
{"token": ["Effect", "of", "IGF-I", "was", "abrogated", "by", "2-bp", "mutations", "in", "either", "the", "C1522505#ent", "<e1>", "response", "element", "(", "C1414819#ent", "<e2>", ")", "or", "homeodomain", "protein-binding", "site", "HOX", ")", "."], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414819", "name": "C1414819#ent", "pos": [16, 17]}}
{"token": ["Disruption", "of", "the", "balance", "between", "MMP", "and", "TIMP", "causes", "various", "diseases", "such", "as", "arthritis", ",", "C0017563#ent", "<e1>", "diabetes", ",", "ophthalmologic", "conditions", "neoplasia", ",", "C0005944#ent", "<e2>", "atherosclerosis", "and", "orthopedic", "conditions"], "h": {"id": "C0017563", "name": "C0017563#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [23, 24]}}
{"token": ["C0016977#ent", "<e1>", "ranges", "in", "severity", "from", "cholelithiasis", "with", "colic", "to", "C0267917#ent", "<e2>", "which", "may", "lead", "to", "shock", "."], "h": {"id": "C0016977", "name": "C0016977#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0267917", "name": "C0267917#ent", "pos": [10, 11]}}
{"token": ["Addition", "of", "TPA", "during", "the", "growth", "phase", "serum-free", "medium", "no", "effect", "lipoprotein", "lipase", "C0023816#ent", "<e1>", ")", ",", "glycerol", "3-phosphate", "dehydrogenase", "(", "GPDH", ")", "and", "C0065558#ent", "<e2>", "ME", ")", "activities", "after", "14", "days", "of", "culture", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0065558", "name": "C0065558#ent", "pos": [24, 25]}}
{"token": ["Tissue", "lipid", "protein", "content", "in", "vivo", "lipogenesis", "rate", ",", "uptake", "of", "diet-derived", "lipids", ",", "in", "vitro", "rate", ",", "adipocyte", "area", "C0023816#ent", "<e1>", "ATP", "citrate", "lyase", "and", "C0065558#ent", "<e2>", "activities", "were", "evaluated", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0065558", "name": "C0065558#ent", "pos": [26, 27]}}
{"token": ["The", "commercially", "available", "preparations", "containing", "C0005026#ent", "<e1>", "those", "of", "C0005320#ent", "<e2>", "and", "levobunolol", "without", "the", "preservative", "had", "similar", "inhibitory", "doses", "50", "%", "of", "cells", "."], "h": {"id": "C0005026", "name": "C0005026#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005320", "name": "C0005320#ent", "pos": [9, 10]}}
{"token": ["C1456542#ent", "<e1>", "induced", "by", "C0158945#ent", "<e2>", "CMV", ")", "infection", "may", "appear", "at", "a", "later", "time", "after", "birth", "as", "a", "consequence", "of", "persistent", "infection", "and/or", "the", "activation", "of", "a", "latent", "infection", "the", "neural", "cells"], "h": {"id": "C1456542", "name": "C1456542#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0158945", "name": "C0158945#ent", "pos": [4, 5]}}
{"token": ["Tosetto", "and", "colleagues", "have", "developed", "a", "mathematical", "method", "quantify", "the", "odds", "of", "having", "C1264040#ent", "<e1>", "on", "a", "C0795956#ent", "<e2>", "family", "history", "bleeding", "score", "and", "VWF", "level", "."], "h": {"id": "C1264040", "name": "C1264040#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0795956", "name": "C0795956#ent", "pos": [17, 18]}}
{"token": ["The", "two", "more", "common", "syndromes", "include", "C0701807#ent", "<e1>", "often", "associated", "with", "keratitis", ",", "and", "the", "C0035319#ent", "<e2>", "ARN", ")", "syndrome", "."], "h": {"id": "C0701807", "name": "C0701807#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035319", "name": "C0035319#ent", "pos": [15, 16]}}
{"token": ["IL-8", "increased", "DNA", "synthesis", "Caco2", "in", "a", "dose", "dependent", "manner", "and", "this", "was", "inhibited", "by", "C2984597#ent", "<e1>", ",", "EGFR", "kinase", ",", "and", "C0003015#ent", "<e2>"], "h": {"id": "C2984597", "name": "C2984597#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [22, 23]}}
{"token": ["These", "data", "suggest", "that", "C0597721#ent", "<e1>", "play", "an", "important", "role", "in", "C0079933#ent", "<e2>", "induced", "transformation", "."], "h": {"id": "C0597721", "name": "C0597721#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079933", "name": "C0079933#ent", "pos": [11, 12]}}
{"token": ["This", "editorial", "highlights", "the", "C1533847#ent", "<e1>", "has", "been", "recognised", "in", "both", "C0029896#ent", "<e2>", ",", "and", "its", "central", "role", "in", "exercise", "limitation", "."], "h": {"id": "C1533847", "name": "C1533847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["However", ",", "IFN-gamma", "stimulation", "or", "assimilation", "of", "catalytic", "LMP2", "and", "C1419018#ent", "<e1>", "proteasomes", "causes", "both", "chymotrypsin-", "and", "C1447694#ent", "<e2>", "the", "proteasome", "to", "become", "limiting", "for", "the", "loading", "of", "class", "I", "molecules"], "h": {"id": "C1419018", "name": "C1419018#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [17, 18]}}
{"token": ["Indicating", "that", "this", "may", "be", "an", "important", "cytotoxic", "lesion", "the", "hypersensitivity", "to", "C0006812#ent", "<e1>", "of", "the", "C1419243#ent", "<e2>", "which", "is", "deficient", "in", "double-strand-break-repair", "."], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419243", "name": "C1419243#ent", "pos": [16, 17]}}
{"token": ["cot-1", "encodes", "a", "C0299851#ent", "<e1>", "is", "structurally", "related", "to", "the", "C0027126#ent", "<e2>", ",", "when", "impaired", ",", "confers", "a", "disease", "that", "involves", "changes", "in", "cytoarchitecture", "and", "ion", "homeostasis"], "h": {"id": "C0299851", "name": "C0299851#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027126", "name": "C0027126#ent", "pos": [10, 11]}}
{"token": ["With", "its", "methodologic", "advantages", ",", "its", "test", "parameter", "being", "more", "relevant", "to", "BT-A", "therapy", ",", "and", "its", "higher", "sensitivity", ",", "the", "C2347126#ent", "<e1>", "appears", "to", "be", "superior", "to", "the", "C0599973#ent", "<e2>", "."], "h": {"id": "C2347126", "name": "C2347126#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0599973", "name": "C0599973#ent", "pos": [29, 30]}}
{"token": ["Furthermore", ",", "our", "analysis", "indicates", "that", "the", "majority", "of", "the", "C1334489#ent", "<e1>", "isoforms", "phosphorylated", "by", "C1332727#ent", "<e2>", "are", "not", "stably", "associated", "with", "chromatin", "."], "h": {"id": "C1334489", "name": "C1334489#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332727", "name": "C1332727#ent", "pos": [15, 16]}}
{"token": ["Taken", "together", ",", "our", "findings", "suggested", "that", "overexpression", "of", "C1419772#ent", "<e1>", "could", "sensitize", "gastric", "cancer", "cells", "chemotherapeutic", "drugs", "downregulating", "the", "C1704467#ent", "<e2>", ",", "MDR-1", "and", "MRP-1", "."], "h": {"id": "C1419772", "name": "C1419772#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [20, 21]}}
{"token": ["Idiopathic", "pulmonary", "fibrosis", "C0034069#ent", "<e1>", ")", "is", "a", "C1335019#ent", "<e2>", "is", "characterized", "by", "the", "formation", "of", "scar", "tissue", "the", "lungs", "in", "the", "absence", "of", "any", "known", "provocation", "."], "h": {"id": "C0034069", "name": "C0034069#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335019", "name": "C1335019#ent", "pos": [8, 9]}}
{"token": ["In", "those", "children", "with", "neither", "cerebral", "palsy", "C1419392#ent", "<e1>", "the", "prevalence", "of", "C0038379#ent", "<e2>", "was", "11", "%", "and", "of", "refractive", "errors", "%", "."], "h": {"id": "C1419392", "name": "C1419392#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038379", "name": "C0038379#ent", "pos": [12, 13]}}
{"token": ["Both", "C3814041#ent", "<e1>", "and", "IL-23", ",", "along", "with", "TGF-beta", ",", "induced", "C1825592#ent", "<e2>", "expression", "independently", "of", "IL-6", "."], "h": {"id": "C3814041", "name": "C3814041#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1825592", "name": "C1825592#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "demonstrate", "that", "newly", "synthesized", "polyglutamine-expanded", "truncated", "huntingtin", "interacts", "with", "members", "of", "Hsp40", "and", "C1415760#ent", "<e1>", "families", "of", "chaperones", "in", "a", "C0032500#ent", "<e2>", "length-dependent", "manner", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032500", "name": "C0032500#ent", "pos": [22, 23]}}
{"token": ["The", "full-length", "cDNA", "of", "C1823076#ent", "<e1>", "is", "1,811", "bp", ",", "with", "an", "C0079941#ent", "<e2>", "1,092", "bp", "."], "h": {"id": "C1823076", "name": "C1823076#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [12, 13]}}
{"token": ["C0246203#ent", "<e1>", "in", "turn", "inhibited", "CYP2C9-catalyzed", "tolbutamide", "and", "C0700583#ent", "<e2>", "hydroxylation", "with", "Ki", "values", "of", "0.3", "and", "0.5", "microM", ",", "respectively", "."], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [8, 9]}}
{"token": ["Contrary", "to", "DNA", "polymerase", "delta", "DNA", "synthesis", "C0012889#ent", "<e1>", "stimulated", "by", "C0114615#ent", "<e2>", "a", "PCNA-dependent", "manner", "."], "h": {"id": "C0012889", "name": "C0012889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0114615", "name": "C0114615#ent", "pos": [11, 12]}}
{"token": ["Derivatization", "of", "4-hydroxyproline", "(", "C0813171#ent", "<e1>", ")", "in", "collagen", "using", "trifluoroacetylation", "and", "C0001962#ent", "<e2>", "esterification", "produces", "two", "derivatives", "when", "analyzed", "by", "gas", "chromatography/mass", "spectrometry", "GC/MS", ")", "."], "h": {"id": "C0813171", "name": "C0813171#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [12, 13]}}
{"token": ["Using", "this", "method", ",", "the", "effect", "of", "unilateral", "6-hydroxydopamine", "(", "C0085196#ent", "<e1>", ")", "lesions", "of", "the", "substantia", "nigra", "C0011501#ent", "<e2>", "retention", "and", "2-DGP", "formation", "by", "the", "striatum", "and", "the", "cerebral", "cortex", "investigated", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011501", "name": "C0011501#ent", "pos": [18, 19]}}
{"token": ["Using", "this", "method", ",", "the", "effect", "of", "unilateral", "C0085196#ent", "<e1>", "(", "6-OHDA", ")", "lesions", "of", "the", "substantia", "nigra", "C0011501#ent", "<e2>", "retention", "and", "2-DGP", "formation", "by", "the", "striatum", "and", "the", "cerebral", "cortex", "investigated", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011501", "name": "C0011501#ent", "pos": [18, 19]}}
{"token": ["The", "erythrogram", "also", "lacked", "specificity", "for", "iron", "deficiency", "C0002871#ent", "<e1>", "as", "many", "patients", "with", "C0085577#ent", "<e2>", "associated", "with", "chronic", "inflammatory", "disease", "increased", "proportions", "of", "hypochromic", "and/or", "microcytic", "red", "blood", "cells"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0085577", "name": "C0085577#ent", "pos": [14, 15]}}
{"token": ["Preparative", "polyacrylamide-gel", "electrophoresis", "the", "glycoprotein", "fraction", "was", "eluted", "with", "C0024748#ent", "<e1>", "a", "relatively", "pure", "preparation", "of", "the", "C1416969#ent", "<e2>"], "h": {"id": "C0024748", "name": "C0024748#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416969", "name": "C1416969#ent", "pos": [17, 18]}}
{"token": ["Multiple", "sclerosis", "C0026269#ent", "<e1>", ")", "is", "thought", "to", "be", "an", "C0004364#ent", "<e2>"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [10, 11]}}
{"token": ["Multiple", "sclerosis", "C0026269#ent", "<e1>", ")", "is", "considered", "as", "a", "T-cell", "mediated", "C0004364#ent", "<e2>"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [11, 12]}}
{"token": ["A", "higher", "absence", "attributable", "to", "infection", "was", "evident", "at", "all", "ages", "in", "C0079414#ent", "<e1>", "children", "than", "in", "those", "in", "C3539652#ent", "<e2>", "."], "h": {"id": "C0079414", "name": "C0079414#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539652", "name": "C3539652#ent", "pos": [19, 20]}}
{"token": ["Similar", "enhancements", "were", "obtained", "in", "mitochondria", "at", "22", "degrees", "C.", "The", "data", "suggests", "a", "somewhat", "higher", "affinity", "of", "C0002598#ent", "<e1>", "to", "mitochondrial", "than", "to", "C1420193#ent", "<e2>"], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "C1420423#ent", "<e1>", "activates", "the", "prostaglandin", "C1422733#ent", "<e2>", "and", "EP4", "receptors", "stimulate", "the", "production", "of", "the", "small", "molecule", "cyclic", "adenosine", "5'", "monophosphate", "cAMP", ")", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422733", "name": "C1422733#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "C1540172#ent", "<e1>", "suppressed", "the", "reduction", "of", "C1826562#ent", "<e2>", "and", "MafA", "expression", "in", "the", "beta", "cells", "which", "may", "be", "one", "of", "the", "cellular", "mechanisms", "protecting", "beta", "cells", "losing", "their", "insulin-secreting", "capacity", "."], "h": {"id": "C1540172", "name": "C1540172#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826562", "name": "C1826562#ent", "pos": [8, 9]}}
{"token": ["In", "summary", ",", "digital", "vibration", "measurement", "can", "elucidate", "C0154743#ent", "<e1>", "CTS", "which", "can", "not", "be", "detected", "by", "C1842357#ent", "<e2>", "studies", "."], "h": {"id": "C0154743", "name": "C0154743#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1842357", "name": "C1842357#ent", "pos": [17, 18]}}
{"token": ["We", "previously", "reported", "that", "binding", "of", "this", "activated", "C1334146#ent", "<e1>", "to", "ICAM-1", "triggers", "a", "signal", ",", "transduced", "by", "the", "C0246976#ent", "<e2>", "that", "activates", "additional", "LFA-1", "molecules"], "h": {"id": "C1334146", "name": "C1334146#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0246976", "name": "C0246976#ent", "pos": [19, 20]}}
{"token": ["Thus", "C1565919#ent", "<e1>", "is", "necessary", "for", "certain", "aspects", "of", "C1321914#ent", "<e2>", "NRVM", "hypertrophy"], "h": {"id": "C1565919", "name": "C1565919#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [9, 10]}}
{"token": ["However", ",", "AdV-DN", "C1565919#ent", "<e1>", "partially", "blocked", "C1321914#ent", "<e2>", "ERK", "activation", "."], "h": {"id": "C1565919", "name": "C1565919#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [7, 8]}}
{"token": ["Comparisons", "of", "the", "peptide", "footprints", "of", "the", "C0072522#ent", "<e1>", "from", "the", "two", "viruses", "using", "C0163582#ent", "<e2>", "after", "immunoprecipitation", "with", "cross-reactive", "MAbs", "revealed", "distinctive", "footprint", "patterns", "for", "the", "respective", "C0072522#ent", "<e1>", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0163582", "name": "C0163582#ent", "pos": [14, 15]}}
{"token": ["A", "peptide", "map", "of", "the", "C0072522#ent", "<e1>", "after", "digestion", "with", "C0163582#ent", "<e2>", "similar", "to", "that", "of", "the", "storage", "protein"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0163582", "name": "C0163582#ent", "pos": [10, 11]}}
{"token": ["Staurosporine", "(", "protein", "kinase", "inhibitor", ",", "tamoxifen", "(", "estrogen", "antagonist", "protein", "kinase", "C", "inhibitor", ",", "C0917964#ent", "<e1>", "(", "protein", "kinase", "A", "activator", ",", "R59949", "(", "diacylglycerol", "kinase", "inhibitor", ",", "curcumin", "and", "C0001047#ent", "<e2>", "(", "scavengers", "of", "reactive", "oxygen", "species", "and", "NaCl", "acted", "as", "inhibitors", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [31, 32]}}
{"token": ["These", "molecules", "activate", "G-protein", "coupled", "receptors", "initiate", "the", "activation", "of", "C1955862#ent", "<e1>", "generation", "of", "oxygen", "radicals", "and", "stimulate", "a", "series", "of", "C0030940#ent", "<e2>", "essential", "roles", "for", "protein", "kinase", "C", "tyrosine", "kinases", "members", "of", "the", "MAP", "kinase", "family"], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [21, 22]}}
{"token": ["In", "an", "immunohistochemical", "study", "using", "formalin-fixed", ",", "paraffin-embedded", "sections", "many", "tumor", "cells", "expressed", "C1421451#ent", "<e1>", ",", "S-100", "protein", "Leu-7", ",", "neuron", "specific", "C1414402#ent", "<e2>", ",", "and", "desmin", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414402", "name": "C1414402#ent", "pos": [22, 23]}}
{"token": ["C1421451#ent", "<e1>", ",", "S-100", "protein", "neuron", "specific", "C1414402#ent", "<e2>", ",", "and", "carcino-embryonic", "antigen", "negative", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414402", "name": "C1414402#ent", "pos": [7, 8]}}
{"token": ["Although", "the", "majority", "of", "tumor", "cells", "expressed", "C1421451#ent", "<e1>", ",", "neuron", "specific", "C1414402#ent", "<e2>", "and", "Leu-7", ",", "there", "were", "no", "tumor", "cells", "positive", "for", "S-100", "protein", "myogenic", "or", "epithelial", "markers", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414402", "name": "C1414402#ent", "pos": [12, 13]}}
{"token": ["The", "Cirrhosis", "Risk", "Score", "(", "C0010278#ent", "<e1>", ")", "was", "calculated", "to", "estimate", "the", "risk", "of", "developing", "C0023890#ent", "<e2>", "for", "each", "patient", "."], "h": {"id": "C0010278", "name": "C0010278#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [16, 17]}}
{"token": ["We", "conclude", "that", "seprase", ",", "FAPalpha", ",", "and", "C1366487#ent", "<e1>", "are", "related", "C1622401#ent", "<e2>", "that", "seprase", "is", "similar", "to", "C1366487#ent", "<e1>", ",", "the", "proteolytic", "activities", "which", "are", "dependent", "upon", "subunit", "association", "."], "h": {"id": "C1622401", "name": "C1622401#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366487", "name": "C1366487#ent", "pos": [8, 9]}}
{"token": ["Within", "this", "group", ",", "MK2", ",", "C1417028#ent", "<e1>", ",", "and", "MK5", "constitute", "three", "structurally", "related", "C3541394#ent", "<e2>", "with", "distinct", "functions", "."], "h": {"id": "C1417028", "name": "C1417028#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}}
{"token": ["Quindoxin", "(", "quinoxaline", "di-N-oxide", ")", "is", "a", "C0162713#ent", "<e1>", "capable", "of", "producing", "C0452157#ent", "<e2>"], "h": {"id": "C0162713", "name": "C0162713#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0452157", "name": "C0452157#ent", "pos": [12, 13]}}
{"token": ["C0032533#ent", "<e1>", "PMR", ")", "is", "a", "C1290886#ent", "<e2>", "unknown", "etiology", "which", "typically", "presents", "with", "symmetric", "myalgias", "the", "shoulder", "and", "pelvic", "girdles"], "h": {"id": "C0032533", "name": "C0032533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1290886", "name": "C1290886#ent", "pos": [6, 7]}}
{"token": ["The", "release", "of", "labeled", "receptor", "into", "the", "medium", "can", "be", "blocked", "by", "the", "addition", "of", "the", "protease", "inhibitors", "aprotinin", "chymostatin", ",", "or", "C0031493#ent", "<e1>", "but", "not", "antipain", ",", "C0064858#ent", "<e2>", ",", "and", "benzamidine", "."], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0064858", "name": "C0064858#ent", "pos": [28, 29]}}
{"token": ["Protease", "inhibitors", "as", "C0031493#ent", "<e1>", "diisopropyl", "fluorophosphate", "L-1-tosylamido-2-phenylethyl", "chloromethyl", "ketone", ",", "aprotinin", ",", "C0064858#ent", "<e2>", ",", "soybean", "trypsin", "inhibitor", "as", "well", "as", "Zn2+", "spermidine", "were", "effective", "inhibitors", "of", "PA", "enzymatic", "activity"], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0064858", "name": "C0064858#ent", "pos": [13, 14]}}
{"token": ["The", "novel", "hybrid", "toxin", "broaden", "the", "utility", "of", "the", "LCTs", "for", "clarifying", "the", "functions", "of", "several", "small", "C0018296#ent", "<e1>", ",", "now", "including", "also", "C0252024#ent", "<e2>", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [17, 18]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0252024", "name": "C0252024#ent", "pos": [23, 24]}}
{"token": ["AS-2", "and", "C2698698#ent", "<e1>", ",", "targeted", "at", "homologous", "regions", "in", "GSTM1", "and", "C1418986#ent", "<e2>", ",", "inhibited", "both", "isoforms", "(", "77", "-", "95", "%", "decrease", ")", "."], "h": {"id": "C2698698", "name": "C2698698#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418986", "name": "C1418986#ent", "pos": [12, 13]}}
{"token": ["Herein", ",", "we", "have", "affinity", "purified", "and", "characterized", "human", "CpG", "binding", "protein", "C1428372#ent", "<e1>", ")", "and", "its", "C1423524#ent", "<e2>", "human", "cells"], "h": {"id": "C1428372", "name": "C1428372#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423524", "name": "C1423524#ent", "pos": [17, 18]}}
{"token": ["In", "vitro", "human", "polymorphic", "neutrophil", "chemotaxis", "studies", "that", "oxidative", "fragmentation", "C0178695#ent", "<e1>", "results", "in", "polymorphic", "neutrophil", "chemotaxis", "that", "C1420308#ent", "<e2>", "can", "completely", "prevent", "this", "response", "."], "h": {"id": "C0178695", "name": "C0178695#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420308", "name": "C1420308#ent", "pos": [18, 19]}}
{"token": ["Lignin", "peroxidases", "LIPs", ")", "and", "C0065647#ent", "<e1>", "MNPs", ")", "are", "major", "components", "of", "the", "C0021669#ent", "<e2>", "Phanerochaete", "chrysosporium", "typically", "appear", "during", "secondary", "metabolism"], "h": {"id": "C0065647", "name": "C0065647#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021669", "name": "C0021669#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "in", "lymphocytes", "fibrates", "augment", "C1423053#ent", "<e1>", "expression", "in", "both", "PPARalpha", "C1883559#ent", "<e2>", "and", "knockout", "mice", "suggesting", "that", "upregulation", "of", "this", "protein", "occurs", "in", "a", "PPARalpha-independent", "manner", "."], "h": {"id": "C1423053", "name": "C1423053#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [12, 13]}}
{"token": ["Bone", "resorption", "markers", "(", "C0631180#ent", "<e1>", "betaCTX", ")", ",", "pyridinoline", ",", "deoxypyridinoline", "(", "C1704716#ent", "<e2>", ")", "]", "were", "6-fold", "increased", "."], "h": {"id": "C0631180", "name": "C0631180#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704716", "name": "C1704716#ent", "pos": [13, 14]}}
{"token": ["Clinical", "manifestations", "anorexia", "have", "multiple", "etiologies", ",", "which", "include", "C0442893#ent", "<e1>", "pain", ",", "fever", ",", "stress", ",", "C0025517#ent", "<e2>", "and", "decreased", "palatability", "and", "learned", "aversion", "food", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [17, 18]}}
{"token": ["All", "C3538771#ent", "<e1>", "lung", "tissue", "showed", "a", "decreased", "expression", "of", "genes", "encoding", "several", "C0031727#ent", "<e2>", "and", "phosphatases", ",", "whereas", "several", "oncogenes", "and", "genes", "coding", "for", "ion", "channel", "proteins", "upregulated", "in", "their", "expression", "."], "h": {"id": "C3538771", "name": "C3538771#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["Transient", "transfection", "experiments", "show", "that", "C1413354#ent", "<e1>", "suppresses", "both", "cap-dependent", "and", "independent", "translation", ",", "while", "C1414356#ent", "<e2>", "both", "translation", "pathways"], "h": {"id": "C1413354", "name": "C1413354#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414356", "name": "C1414356#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", "to", "C1414356#ent", "<e1>", "human", "C1413354#ent", "<e2>", ",", "a", "translation", "inhibitor", "homology", "to", "C1414356#ent", "<e1>", "binds", "eIF4A", "only", "through", "the", "amino-terminal", "proximal", "region", ",", "which", "is", "homologous", "to", "the", "middle", "domain", "of", "C1414356#ent", "<e1>"], "h": {"id": "C1413354", "name": "C1413354#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414356", "name": "C1414356#ent", "pos": [3, 4]}}
{"token": ["The", "first", ",", "C3538851#ent", "<e1>", ",", "a", "negative", "regulator", "of", "C0525678#ent", "<e2>", ",", "is", "expressed", "within", "axons", "and", "growth", "cones", "developing", "granule", "cells"], "h": {"id": "C3538851", "name": "C3538851#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}}
{"token": ["Structural", "analogs", "of", "C3713294#ent", "<e1>", "represent", "a", "new", "class", "of", "compounds", "with", "the", "potential", "for", "treating", "C0029896#ent", "<e2>", "caused", "by", "C3713294#ent", "<e1>", "kinase-containing", "microorganisms", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3713294", "name": "C3713294#ent", "pos": [3, 4]}}
{"token": ["This", "was", "accompanied", "with", "down-regulation", "in", "surface", "expression", "of", "C1705581#ent", "<e1>", "and", "up-regulation", "of", "CD14", ",", "C1539081#ent", "<e2>", ",", "and", "TLR2", "."], "h": {"id": "C1705581", "name": "C1705581#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539081", "name": "C1539081#ent", "pos": [16, 17]}}
{"token": ["Oral", "movements", "not", "be", "reelicited", "by", "an", "infusion", "of", "apomorphine", "into", "the", "C1846860#ent", "<e1>", "after", "a", "C0022471#ent", "<e2>", "lesion", "of", "the", "C1846860#ent", "<e1>", "."], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1846860", "name": "C1846860#ent", "pos": [12, 13]}}
{"token": ["The", "mainly", "hydrolize", "alpha-", "and", "beta-glucosides", ",", "alpha-", "and", "C0085131#ent", "<e1>", "as", "well", "as", "C0054259#ent", "<e2>", "."], "h": {"id": "C0085131", "name": "C0085131#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [14, 15]}}
{"token": ["Enterococci", "with", "multiple", "high-level", "C0002556#ent", "<e1>", "but", "not", "vancomycin", "resistance", "or", "C0005244#ent", "<e2>", "production", ",", "are", "common", "at", "this", "referral", "medical", "center"], "h": {"id": "C0002556", "name": "C0002556#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0005244", "name": "C0005244#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "LCLs", "expressed", "surface", "light", "chains", ",", "high", "densities", "C3273108#ent", "<e1>", ",", "low", "densities", "PCA1", "antigen", ",", "and", "no", "C3887624#ent", "<e2>"], "h": {"id": "C3273108", "name": "C3273108#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [21, 22]}}
{"token": ["Following", "HIV-1", "infection", "LCL", "cells", "showed", "a", "decrease", "in", "B-cell", "activation", "C3273108#ent", "<e1>", "and", "CD39", ",", "and", "an", "increase", "in", "C3887624#ent", "<e2>", "immature", "B-cell", "antigen"], "h": {"id": "C3273108", "name": "C3273108#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [20, 21]}}
{"token": ["All", "the", "transformed", "cell", "lines", "a", "cell", "surface", "phenotype", "characteristic", "of", "well-differentiated", "peripheral", "blood", "cells", "expressing", "C3273108#ent", "<e1>", "and", "CD38", "while", "weakly", "expressing", "C3887624#ent", "<e2>", "and", "CD21", "."], "h": {"id": "C3273108", "name": "C3273108#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [23, 24]}}
{"token": ["The", "results", "indicated", "a", "time-", "and", "concentration-dependent", "depletion", "of", "glutathione", "(", "C1260386#ent", "<e1>", ")", ",", "which", "was", "greater", "in", "the", "immature", "C0018889#ent", "<e2>", "after", "incubation", "with", "ART", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [21, 22]}}
{"token": ["The", "results", "indicated", "a", "time-", "and", "concentration-dependent", "depletion", "of", "glutathione", "(", "C1260386#ent", "<e1>", ")", ",", "which", "was", "greater", "in", "the", "immature", "C0018889#ent", "<e2>", "after", "incubation", "with", "ART", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [21, 22]}}
{"token": ["C0012789#ent", "<e1>", "reversed", "the", "inhibition", "of", "Cl(-)-stimulated", "C0001473#ent", "<e2>", "induced", "by", "p-chloromercuribenzenesulfonate", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [7, 8]}}
{"token": ["We", "report", "on", "a", "13-year-old", "girl", "with", "complete", "C1416765#ent", "<e1>", "KSS", ")", "and", "unusual", "manifestations", "of", "anhidrosis", "and", "C0341703#ent", "<e2>", "preceded", "by", "several", "years", "the", "onset", "of", "KSS", "triad"], "h": {"id": "C1416765", "name": "C1416765#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0341703", "name": "C0341703#ent", "pos": [18, 19]}}
{"token": ["In", "the", "case", "of", "the", "DNA", "fragments", "capillary", "electrochromatography", "used", "with", "a", "C18-modified", "C0070302#ent", "<e1>", "chip", "and", "a", "carrier", "C3536863#ent", "<e2>", "containing", "an", "ion-pairing", "agent", "."], "h": {"id": "C0070302", "name": "C0070302#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [19, 20]}}
{"token": ["Western", "immunoblot", "luciferase", "reporter", "studies", "showed", "that", "Pseudomonas-induced", "C1413978#ent", "<e1>", "upregulation", "involved", "MyD88", ",", "C0248813#ent", "<e2>", "both", "AP-1", "and", "NF-kappaB", "transcription", "factors"], "h": {"id": "C1413978", "name": "C1413978#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [14, 15]}}
{"token": ["The", "C0083701#ent", "<e1>", "metabolites", ",", "like", "the", "parent", "compound", "no", "alpha", "2-", "or", "C0001644#ent", "<e2>", "affinity", "."], "h": {"id": "C0083701", "name": "C0083701#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [13, 14]}}
{"token": ["C0960371#ent", "<e1>", "stimulation", "of", "inhibitory", "kappa", "B", "kinases", "C1704987#ent", "<e2>", "and", "IKKbeta", ",", "was", "also", "inhibited", "following", "pretreatment", "with", "BAPTA-AM", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704987", "name": "C1704987#ent", "pos": [8, 9]}}
{"token": ["Interestingly", ",", "transfectants", "with", "SIGNR1", "lacking", "the", "cytoplasmic", "domain", "capable", "of", "binding", "FITC-zymosan", "in", "a", "manner", "that", "was", "abolished", "by", "C0012695#ent", "<e1>", "or", "mannan", ",", "but", "not", "C0064631#ent", "<e2>", "."], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0064631", "name": "C0064631#ent", "pos": [27, 28]}}
{"token": ["The", "tremor", "of", "a", "patient", "with", "C0270736#ent", "<e1>", "could", "not", "take", "C0033497#ent", "<e2>", "(", "because", "of", "severe", "asthma", ")", "was", "dramatically", "reduced", "when", "metoprolol", "tartrate", "was", "administered", "in", "standard", "doses"], "h": {"id": "C0270736", "name": "C0270736#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [11, 12]}}
{"token": ["Abnormal", "patterns", "of", "potential", "distribution", "were", "found", "in", "C0003507#ent", "<e1>", "including", "three", "patients", "without", "electrocardiographic", "evidence", "C0162770#ent", "<e2>"], "h": {"id": "C0003507", "name": "C0003507#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162770", "name": "C0162770#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "suggest", "that", "the", "antiviral", "effect", "DHEA", "is", "not", "linked", "directly", "to", "the", "genomic", "steroid-receptor", "pathways", "and", "suggest", "that", "the", "signalling", "pathways", "C1705791#ent", "<e1>", "play", "a", "role", "in", "the", "C0003451#ent", "<e2>", "DHEA", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [30, 31]}}
{"token": ["When", "other", "diseases", "that", "bring", "about", "C0158617#ent", "<e1>", "be", "excluded", ",", "C0039263#ent", "<e2>", "be", "considered", ",", "even", "if", "most", "of", "its", "manifestations", "are", "absent", "."], "h": {"id": "C0158617", "name": "C0158617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039263", "name": "C0039263#ent", "pos": [11, 12]}}
{"token": ["These", "C0037285#ent", "<e1>", "association", "with", "the", "C0003509#ent", "<e2>", "suggest", "that", "both", "had", "Takayasu's", "arteritis"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003509", "name": "C0003509#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "DmADDA", "was", "detected", "from", "the", "male", "ddY", "mice", "C0023899#ent", "<e1>", "orally", "administered", "C0056661#ent", "<e2>"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0056661", "name": "C0056661#ent", "pos": [14, 15]}}
{"token": ["The", "amplitude", "of", "the", "rebound", "heart", "rate", "to", "the", "control", "heart", "rate", "beta-blockers", "was", "similar", "after", "propranolol", ",", "C0004147#ent", "<e1>", ",", "oxprenolol", ",", "or", "acebutolol", ",", "and", "in", "C0020550#ent", "<e2>", "subjects", "."], "h": {"id": "C0004147", "name": "C0004147#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [28, 29]}}
{"token": ["We", "have", "examined", "the", "speed", "and", "accuracy", "of", "localisation", "of", "leucocytes", "labelled", "plasma", "with", "a", "new", "C3537172#ent", "<e1>", "indium-111", "tropolonate", "in", "90", "patients", "with", "suspected", "C0243001#ent", "<e2>"], "h": {"id": "C3537172", "name": "C3537172#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0243001", "name": "C0243001#ent", "pos": [25, 26]}}
{"token": ["Previous", "examination", "of", "C0064833#ent", "<e1>", "these", "animals", "indicated", "that", "these", "C0031727#ent", "<e2>", "were", "critical", "in", "initiating", "the", "actin", "cytoskeletal", "rearrangements", "that", "lead", "to", "respiratory", "burst", "granule", "secretion", "integrin", "ligation"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "the", "efficacy", "and", "tolerability", "of", "C0036078#ent", "<e1>", "(", "SSZ", ")", "in", "the", "treatment", "of", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["These", "studies", "suggest", "that", "one", "major", "characteristic", "of", "C2721575#ent", "<e1>", "the", "dog", "is", "a", "C0025517#ent", "<e2>", "in", "the", "filtration", "process"], "h": {"id": "C2721575", "name": "C2721575#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [14, 15]}}
{"token": ["The", "gall-bladder", "tissues", "obtained", "from", "7", "cases", "of", "C0267853#ent", "<e1>", "and", "1", "case", "of", "C0947622#ent", "<e2>", "were", "used", "as", "materials", "in", "the", "present", "study", "."], "h": {"id": "C0267853", "name": "C0267853#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [14, 15]}}
{"token": ["phi", "29", "DNA", "polymerase", "with", "other", "C0012888#ent", "<e1>", "regions", "of", "C2917660#ent", "<e2>", "similarity", "."], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [10, 11]}}
{"token": ["Unlike", "the", "C0149721#ent", "<e1>", "there", "was", "no", "significant", "difference", "between", "C0126174#ent", "<e2>", "and", "amlodipine", "in", "the", "effects", "on", "non-hypertrophied", "right", "ventricular", "gene", "of", "SHRSP", "."], "h": {"id": "C0149721", "name": "C0149721#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "the", "arteries", "without", "C3812627#ent", "<e1>", "showed", "greater", "sensitivity", "to", "C1705457#ent", "<e2>", "and", "nitrates", "than", "did", "the", "arteries", "of", "the", "control", "patients.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C3812627", "name": "C3812627#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705457", "name": "C1705457#ent", "pos": [11, 12]}}
{"token": ["The", "ribosomal", "protein", "L3", "a", "highly", "conserved", "protein", "located", "at", "the", "peptidyltransferase", "center", "the", "ribosomes", ",", "is", "involved", "in", "binding", "of", "C1424700#ent", "<e1>", "to", "ribosomes", "and", "subsequent", "depurination", "of", "the", "C1420403#ent", "<e2>", "."], "h": {"id": "C1424700", "name": "C1424700#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420403", "name": "C1420403#ent", "pos": [30, 31]}}
{"token": ["The", "media/lumen", "ratio", "was", "reduced", "by", "pioglitazone", ";", "in", "MRA", ",", "combination", "treatment", "C0074554#ent", "<e1>", "reduced", "the", "ratio", "further", "to", "normal", "and", ",", "with", "C0216784#ent", "<e2>", ",", "to", "below", "normal", "."], "h": {"id": "C0074554", "name": "C0074554#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0216784", "name": "C0216784#ent", "pos": [24, 25]}}
{"token": ["C0164707#ent", "<e1>", "is", "internalized", "and", "degraded", "by", "HepG2", "cells", "the", "low-density-lipoprotein", "receptor-related", "protein", "C1419111#ent", "<e2>", ")", "but", "also", "binds", "another", "molecule", "present", "on", "the", "cell", "surface", "approx", "."], "h": {"id": "C0164707", "name": "C0164707#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419111", "name": "C1419111#ent", "pos": [13, 14]}}
{"token": ["Together", ",", "our", "results", "suggest", "that", "while", "the", "majority", "of", "C0164707#ent", "<e1>", "binds", "to", "cell", "surface", ",", "C1419111#ent", "<e2>", "can", "function", "independently", "from", "HSPGs", "in", "the", "binding", "and", "uptake", "of", "C0164707#ent", "<e1>", "."], "h": {"id": "C0164707", "name": "C0164707#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419111", "name": "C1419111#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "the", "effects", "of", "heat", "treatment", "60", "degrees", "C", "on", "the", "characteristics", "of", "the", "CS-MAS", "dispersions", "and", "the", "zeta", "potential", "C0812372#ent", "<e1>", "upon", "addition", "of", "CS", "at", "different", "C1705397#ent", "<e2>", "were", "examined", "."], "h": {"id": "C0812372", "name": "C0812372#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [29, 30]}}
{"token": ["More", "importantly", ",", "not", "only", "do", "extracellular", "C3541396#ent", "<e1>", "ions", "affect", "signal", "transduction", "but", "growth", "factors", "induce", "cellular", "C3541396#ent", "<e1>", "fluctuations", "that", "are", "of", "sufficient", "magnitude", "to", "inhibit", "C0085536#ent", "<e1>"], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [28, 29]}}
{"token": ["Clinical", "experience", "using", "systemic", "Cyclosporin", "A", "(", "C0751039#ent", "<e1>", ")", "in", "the", "dermatological", "therapy", "the", "C3665333#ent", "<e2>", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3665333", "name": "C3665333#ent", "pos": [15, 16]}}
{"token": ["The", "114", "specimens", "from", "syphilis", "cases", "comprised", "40", "from", "cases", "of", "primary", "syphilis", "43", "from", "cases", "of", "secondary", "syphilis", "19", "from", "cases", "of", "early", "C0039133#ent", "<e1>", "and", "12", "from", "cases", "of", "C1260915#ent", "<e2>"], "h": {"id": "C0039133", "name": "C0039133#ent", "pos": [24, 25]}, "relation": "nichd_parent_of", "t": {"id": "C1260915", "name": "C1260915#ent", "pos": [31, 32]}}
{"token": ["Sensitivity", "of", "the", "VDRL", "test", "is", "high", "in", "secondary", "and", "early", "C0039133#ent", "<e1>", "reduced", "in", "primary", "and", "C1260915#ent", "<e2>", "in", "cerebrospinal", "fluid", "evaluations", "."], "h": {"id": "C0039133", "name": "C0039133#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C1260915", "name": "C1260915#ent", "pos": [17, 18]}}
{"token": ["Although", "C0026848#ent", "<e1>", "generally", "more", "severe", "in", "DM1", ",", "the", "C0035541#ent", "<e2>", "inclusions", "were", "8-", "to", "13-fold", "more", "intense", "in", "DM2", ",", "implying", "greater", "amounts", "of", "repeat", "expansion", "RNA"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [10, 11]}}
{"token": ["The", "rank", "order", "of", "oral", "activity", "C0078442#ent", "<e1>", ">", "betamethasone", ">", "ADCA", "for", "C0014457#ent", "<e2>", "betamethasone", ">", "C0078442#ent", "<e1>", "=", "ADCA", "for", "transdermal", "chemotaxis", "."], "h": {"id": "C0078442", "name": "C0078442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [13, 14]}}
{"token": ["In", "12", "patients", ",", "laparoscopic", "surgery", "converted", "to", "an", "open", "procedure", "of", "severe", "inflammation", ",", "C0014013#ent", "<e1>", ",", "dense", "adhesions", "carcinoma", "of", "the", "gallbladder", ",", "cholecystoduodenal", "fistula", "and", "C0021845#ent", "<e2>"], "h": {"id": "C0014013", "name": "C0014013#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021845", "name": "C0021845#ent", "pos": [28, 29]}}
{"token": ["Here", ",", "we", "identified", "a", "subpopulation", "of", "CD4(+)CD25(-)PD-1(+", ")", "T", "cells", "the", "spleen", "of", "naive", "mice", "that", "C0669365#ent", "<e1>", "expressed", "CTLA-4", "and", "C1416467#ent", "<e2>", "and", "was", "hypoproliferative", "in", "response", "to", "anti-CD3", "antibody", "stimulation", "in", "vitro"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416467", "name": "C1416467#ent", "pos": [22, 23]}}
{"token": ["Phosphorylation", "of", "the", "20", "kDa", "C1417546#ent", "<e1>", "smooth", "muscle", "five", "different", "C0010536#ent", "<e2>", "was", "investigated", "."], "h": {"id": "C1417546", "name": "C1417546#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [11, 12]}}
{"token": ["Previously", "we", "found", "that", "C3537336#ent", "<e1>", "X11L", ")", "associates", "with", "C1364818#ent", "<e2>", "APP", ")", "."], "h": {"id": "C3537336", "name": "C3537336#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [10, 11]}}
{"token": ["C0431693#ent", "<e1>", "an", "uncommon", "type", "of", "C1691228#ent", "<e2>"], "h": {"id": "C0431693", "name": "C0431693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1691228", "name": "C1691228#ent", "pos": [6, 7]}}
{"token": ["Cytochemically", ",", "Na+/K(+)-ATPase", "activity", "appeared", "to", "be", "decreased", "in", "the", "C0013604#ent", "<e1>", "vascularis", "of", "C0206586#ent", "<e2>"], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0206586", "name": "C0206586#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "hypophosphorylation", "of", "C1705761#ent", "<e1>", "and", "repression", "of", "cyclin", "D3", "C1332719#ent", "<e2>", "are", "induced", "synergistically", "by", "treatment", "with", "ATRA", "plus", "GM-CSF", "in", "ML-1", "cells"], "h": {"id": "C1705761", "name": "C1705761#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332719", "name": "C1332719#ent", "pos": [13, 14]}}
{"token": ["Also", "oral", "manifestations", "mostly", "recurrent", "apthous", "stomatitis", "C0034678#ent", "<e1>", ")", "and", "dental", "enamel", "hypoplasia", "are", "atypical", "signs", "C1705969#ent", "<e2>", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [17, 18]}}
{"token": ["i", ")", "C1120776#ent", "<e1>", "adapts", "the", "'", "open", "'", "conformation", "in", "C0040853#ent", "<e2>", ",", "with", "the", "alpha-helical", "surface", "loop", "moving", "so", "as", "to", "expose", "the", "active", "site"], "h": {"id": "C1120776", "name": "C1120776#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040853", "name": "C0040853#ent", "pos": [11, 12]}}
{"token": ["In", "rabbits", "subjected", "to", "2", "h", "of", "C0007787#ent", "<e1>", "n", "=", "5", ")", ",", "two", "phases", "of", "C2917660#ent", "<e2>", "release", "were", "seen", "."], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [17, 18]}}
{"token": ["Early", "and", "late", "phase", "glucoheptonate", "scanning", "was", "performed", "in", "42", "children", "as", "part", "of", "the", "evaluation", "of", "recurrent", "C0009952#ent", "<e1>", "urinary", "tract", "infections", "or", "without", "a", "history", "of", "C1970483#ent", "<e2>"], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1970483", "name": "C1970483#ent", "pos": [28, 29]}}
{"token": ["The", "combinatorial", "method", "been", "applied", "to", "determine", "the", "sequence", "specificity", "8", "SH2", "domains", "Src", "and", "Csk", "kinases", "adaptor", "protein", "Grb2", ",", "and", "C0214604#ent", "<e1>", "SHP-2", ",", "and", "SHIP1", "and", "a", "prototypical", "PTP", ",", "C1709439#ent", "<e2>", "."], "h": {"id": "C0214604", "name": "C0214604#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1709439", "name": "C1709439#ent", "pos": [33, 34]}}
{"token": ["C1415068#ent", "<e1>", "should", "be", "analyzed", "in", "all", "patients", "without", "C1412466#ent", "<e2>", "mutations", "but", "should", "also", "be", "considered", "the", "initial", "genetic", "test", "women", "and", "in", "patients", "with", "consanguineous", "parents", "."], "h": {"id": "C1415068", "name": "C1415068#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412466", "name": "C1412466#ent", "pos": [9, 10]}}
{"token": ["We", "wanted", "to", "investigate", "C0935929#ent", "<e1>", "diuretics", "for", "potential", "C1527358#ent", "<e2>", "and", "possible", "DNA", "damage", "the", "HaCaT", "cell", "line", "."], "h": {"id": "C0935929", "name": "C0935929#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1527358", "name": "C1527358#ent", "pos": [9, 10]}}
{"token": ["This", "enhanced", "ameliorating", "effect", "of", "C0076502#ent", "<e1>", "was", "antagonized", "by", "pyrilamine", ",", "a", "C0019592#ent", "<e2>", "(R)-alpha-methylhistamine", ",", "a", "histamine", "H3-receptor", "agonist", ",", "suggesting", "that", "C0076502#ent", "<e1>", "showed", "the", "ameliorating", "effect", "via", "histamine", "H3", "receptors", "histamine", "H1", "receptors"], "h": {"id": "C0076502", "name": "C0076502#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019592", "name": "C0019592#ent", "pos": [13, 14]}}
{"token": ["The", "remaining", "16", "patients", "had", "no", "evidence", "of", "C1840402#ent", "<e1>", "yet", "had", "an", "C0003892#ent", "<e2>", "causing", "pain", "and", "stiffness", "in", "many", "joints", ",", "particularly", "the", "shoulders", "."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003892", "name": "C0003892#ent", "pos": [13, 14]}}
{"token": ["Unless", "significant", "changes", "occur", "in", "emergency", "medicine", "C1705457#ent", "<e1>", ")", "organization", "and", "practice", "structures", "C0221271#ent", "<e2>", "will", "have", "less", "self-determination", "over", "their", "practice", "compared", "with", "other", "specialties", "."], "h": {"id": "C1705457", "name": "C1705457#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221271", "name": "C0221271#ent", "pos": [14, 15]}}
{"token": ["These", "results", "support", "the", "hypothesis", "that", "catechol", "estrogens", "interfere", "with", "catecholamine", "metabolism", "acting", "as", "inhibitors", "of", "C3540790#ent", "<e1>", "involved", "in", "catecholamine", "metabolism", "such", "as", "C0012312#ent", "<e2>"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012312", "name": "C0012312#ent", "pos": [24, 25]}}
{"token": ["A", "combination", "of", "leucine", ",", "phenylalanine", "and", "tyrosine", ",", "which", "we", "showed", "previously", "to", "stimulate", "PI", "3-kinase-dependent", "phosphorylation", "of", "C1419741#ent", "<e1>", "did", "not", "stimulate", "C0002245#ent", "<e2>", "production", "from", "glucose", "."], "h": {"id": "C1419741", "name": "C1419741#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [24, 25]}}
{"token": ["This", "study", "investigates", "these", "problems", "for", "the", "delivery", "of", "a", "dominant-negative", "rev", "gene", "humanized", "C0796697#ent", "<e1>", ")", "by", "a", "C1520007#ent", "<e2>"], "h": {"id": "C0796697", "name": "C0796697#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1520007", "name": "C1520007#ent", "pos": [19, 20]}}
{"token": ["Pituitary", "adenylate", "cyclase", "activating", "protein", "PACAP", ")", "and", "its", "structurally", "related", "vasointestinal", "peptide", "VIP", ")", "bind", "to", "three", "G-protein-coupled", "receptors", "VPAC1", "and", "C1421452#ent", "<e1>", "for", "VIP/PACAP", "receptors", "and", "C1537486#ent", "<e2>", "for", "PACAP", "preferred", "receptors", "."], "h": {"id": "C1421452", "name": "C1421452#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1537486", "name": "C1537486#ent", "pos": [28, 29]}}
{"token": ["The", "increased", "expression", "of", "C0087140#ent", "<e1>", "mRNA", "suggests", "to", "attenuate", "PBMC", "response", "to", "C1415097#ent", "<e2>", ",", "which", "may", "contribute", "to", "progression", "of", "GC", "resistance", "in", "asthma", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415097", "name": "C1415097#ent", "pos": [13, 14]}}
{"token": ["They", "include", "C1334706#ent", "<e1>", "(", "matrix", "metalloproteinases", "adamalysins", ",", "or", "C2984583#ent", "<e2>", ")", ",", "serine", "proteases", "elastase", ",", "coagulation", "factors", "plasmin", ",", "tissue", "plasminogen", "activator", "urokinase", "plasminogen", "activator", ",", "and", "the", "cysteine", "proteases", "such", "cathepsins", ")", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2984583", "name": "C2984583#ent", "pos": [10, 11]}}
{"token": ["The", "drugs", "investigated", "were", "chloroquine", ",", "betamethasone", ",", "C0033229#ent", "<e1>", "(", "phospholipase", "A2", "inhibitors", ",", "ketoprofen", "(", "cyclo-oxygenase", "inhibitor", "and", "C0020923#ent", "<e2>", "(", "TxA2", "synthetase", "inhibitor", ")", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020923", "name": "C0020923#ent", "pos": [20, 21]}}
{"token": ["However", ",", "the", "addition", "of", "C3641819#ent", "<e1>", "recruited", "molar", "excesses", "of", "either", "protein", "to", "membranes", ",", "indicating", "that", "C3641819#ent", "<e1>", "activates", "both", "pro-", "and", "antiapoptotic", "members", "the", "C1332391#ent", "<e1>"], "h": {"id": "C3641819", "name": "C3641819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332391", "name": "C1332391#ent", "pos": [27, 28]}}
{"token": ["Thirty-six", "patients", ",", "mean", "age", "years", ",", "suffering", "from", "slight", "or", "moderate", "C0020538#ent", "<e1>", "treated", "with", "40", "mg", "of", "C0028005#ent", "<e2>", "retard", "twice", "a", "day", "(", "b.i.d", ".", ")", ","], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [19, 20]}}
{"token": ["We", "studied", "the", "effect", "of", "this", "C0013227#ent", "<e1>", "in", "differentiating", "3T3-L1", "adipocytes", "and", "found", "that", "C0770893#ent", "<e2>", "causes", "oxidative", "stress", "it", "increases", "the", "levels", "of", "reactive", "oxygen", "species", "ROS", ")", "and", "lowers", "the", "aconitase", "activity"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "report", "that", "blockade", "of", "the", "epidermal", "growth", "factor", "receptor", "EGFR", ")", "C0211705#ent", "<e1>", "with", "AG-1478", "markedly", "delays", "breast", "tumor", "formation", "in", "mouse", "mammary", "tumor", "virus", "+", "C1336620#ent", "<e2>", "mice", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1336620", "name": "C1336620#ent", "pos": [28, 29]}}
{"token": ["Other", "authors", "have", "suggested", "that", "EM", "and", "C1413668#ent", "<e1>", "result", "from", "the", "action", "of", "C1412446#ent", "<e2>", "on", "two", "distinct", "targets", ",", "i.e.", "endothelial", "cells", "EM", "and", "myocytes", "for", "C1413668#ent", "<e1>", "."], "h": {"id": "C1413668", "name": "C1413668#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412446", "name": "C1412446#ent", "pos": [14, 15]}}
{"token": ["We", "compared", "the", "safety", "profile", "and", "efficacy", "of", "brimonidine", "0.2", "%", "C1332410#ent", "<e1>", "with", "those", "of", "C0040233#ent", "<e2>", "0.5", "%", "C1332410#ent", "<e1>", "over", "3", "years", "in", "patients", "with", "ocular", "hypertension", "glaucoma", "."], "h": {"id": "C1332410", "name": "C1332410#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040233", "name": "C0040233#ent", "pos": [16, 17]}}
{"token": ["To", "evaluate", "the", "inflammatory", "response", "the", "cardiopulmonary", "bypass", "we", "investigated", "the", "serum", "levels", "of", "tumor", "necrosis", "factor", "alpha", "TNF", "alpha", ",", "interleukin", "8", "C1366571#ent", "<e1>", ")", ",", "and", "the", "expression", "of", "leukocyte", "adhesion", "molecule", "C1706333#ent", "<e2>", "."], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1706333", "name": "C1706333#ent", "pos": [34, 35]}}
{"token": ["The", "C1335796#ent", "<e1>", "counts", "in", "these", "C0020437#ent", "<e2>", "patients", "were", "48.2", "+", "/-", "13.0", ",", "a", "statistically", "significant", "increase", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [6, 7]}}
{"token": ["Rad26", "is", "a", "member", "of", "the", "C1335883#ent", "<e1>", "proteins", "that", "either", "disrupt", "C0008546#ent", "<e2>", "or", "facilitate", "interactions", "between", "the", "RNA", "Pol", "II", "transcription", "activators", "."], "h": {"id": "C1335883", "name": "C1335883#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [12, 13]}}
{"token": ["The", "C1335883#ent", "<e1>", "chromatin-remodeling", "complexes", "gene", "activation", "assisting", "transcription", "machinery", "gain", "access", "to", "targets", "in", "C0008546#ent", "<e2>", "."], "h": {"id": "C1335883", "name": "C1335883#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [15, 16]}}
{"token": ["C0039254#ent", "<e1>", "is", "one", "of", "the", "major", "food-borne", "C0043528#ent", "<e2>", "Thailand", "."], "h": {"id": "C0039254", "name": "C0039254#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [8, 9]}}
{"token": ["NAT", "activity", "in", "M.", "tuberculosis", "likely", "therefore", "to", "modulate", "the", "degree", "of", "activation", "of", "C0022209#ent", "<e1>", "by", "other", "enzymes", "within", "the", "C0026918#ent", "<e2>"], "h": {"id": "C0022209", "name": "C0022209#ent", "pos": [14, 15]}, "relation": "may_prevent", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [21, 22]}}
{"token": ["A", "review", "of", "the", "literature", "on", "C0154723#ent", "<e1>", "reveals", "that", "C0522357#ent", "<e2>", "not", "uncommonly", "associated", "with", "C0154723#ent", "<e1>", "in", "various", "temporal", "relationships", "headache", "and/or", "other", "neurologic", "symptoms"], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0522357", "name": "C0522357#ent", "pos": [10, 11]}}
{"token": ["The", "introduction", "of", "an", "assay", "for", "C0001497#ent", "<e1>", "the", "study", "of", "renin", "release", "from", "isolated", "C0268731#ent", "<e2>", "is", "a", "useful", "tool", "in", "determining", "the", "specificity", "of", "the", "release", "process", "."], "h": {"id": "C0001497", "name": "C0001497#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [15, 16]}}
{"token": ["C0001497#ent", "<e1>", "3", ",", "in", "contrast", ",", "was", "high", "in", "C0268731#ent", "<e2>", ",", "proximal", "segments", ",", "thick", "ascending", "limb", "of", "Henle", ",", "and", "distal", "convoluted", "tubules"], "h": {"id": "C0001497", "name": "C0001497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [10, 11]}}
{"token": ["The", "patient", "was", "a", "homosexual", "male", "receiving", "maintainance", "treatment", "with", "foscarnet", "for", "previous", "C0035333#ent", "<e1>", "by", "CMV", "who", "consulted", "for", "C0037771#ent", "<e2>", "and", "sphincter", "disorders", "a", "3", "week", "evolution", "."], "h": {"id": "C0035333", "name": "C0035333#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0037771", "name": "C0037771#ent", "pos": [20, 21]}}
{"token": ["All", "C0036117#ent", "<e1>", "isolates", "were", "resistant", "to", "5", "or", "more", "of", "13", "C0003207#ent", "<e2>", "tested", "."], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003207", "name": "C0003207#ent", "pos": [12, 13]}}
{"token": ["The", "C1414643#ent", "<e1>", "FMO", ")", "and", "cytochrome", "P-450", "C0608437#ent", "<e2>", ")", "are", "the", "two", "main", "microsomal", "enzyme", "systems", "involved", "in", "the", "oxidation", "of", "xenobiotics", "."], "h": {"id": "C1414643", "name": "C1414643#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [8, 9]}}
{"token": ["By", "using", "a", "polymerase", "chain", "reaction-based", "assay", "amplified", "products", "of", "expected", "size", "were", "obtained", "in", "all", "of", "the", "C0020097#ent", "<e1>", "(", "n", "=", "7", ")", "and", "C0019693#ent", "<e2>", "(", "n", "=", "8)", "cell", "lines"], "h": {"id": "C0020097", "name": "C0020097#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [26, 27]}}
{"token": ["We", "then", "used", "flow", "dialysis", "CD", "spectropolarimetry", "assays", "to", "demonstrate", "that", "C1420882#ent", "<e1>", "binds", "Ca2", "+", "with", "a", "dissociation", "constant", "(", "C1705240#ent", "<e2>", ")", "of", "approx", "."], "h": {"id": "C1420882", "name": "C1420882#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [21, 22]}}
{"token": ["During", "one", "period", "of", "entrainment", ",", "termination", "of", "the", "reentrant", "arrhythmia", "because", "C1334902#ent", "<e1>", "blocked", "in", "the", "reentrant", "pathway", "to", "refractory", "tissue", "left", "C4084753#ent", "<e2>", "."], "h": {"id": "C1334902", "name": "C1334902#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4084753", "name": "C4084753#ent", "pos": [23, 24]}}
{"token": ["The", "temporary", "high", "brain", "C1418873#ent", "<e1>", "concentrations", "and", "the", "C0394006#ent", "<e2>", "brain", "and", "serum", "concentrations", "after", "rapid", "i.v", "."], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "cardiovascular", "autonomic", "function", "C1710621#ent", "<e1>", "patients", "with", "paroxysmal", "atrial", "fibrillation", "significant", "C0018799#ent", "<e2>"], "h": {"id": "C1710621", "name": "C1710621#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [20, 21]}}
{"token": ["A", "mentally", "retarded", "girl", "with", "congenital", "blepharophimosis", "C0005745#ent", "<e1>", ",", "hypoplastic", "teeth", "other", "traits", "consistent", "with", "C0796094#ent", "<e2>", "reported", "."], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0796094", "name": "C0796094#ent", "pos": [16, 17]}}
{"token": ["Two", "new", "glucose", "6-phosphate", "dehydrogenase", "C0017757#ent", "<e1>", ")", "variants", "associated", "with", "chronic", "nonspherocytic", "hemolytic", "anemia", "discovered", ",", "C1333652#ent", "<e2>", "found", "in", "a", "16-year-old", "male", "associated", "with", "hemolytic", "crisis", "upper", "respiratory", "infection"], "h": {"id": "C0017757", "name": "C0017757#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333652", "name": "C1333652#ent", "pos": [17, 18]}}
{"token": ["We", "used", "normal", "rat", "liver", ",", "primary", "hepatocyte", "cultures", "and", "a", "dominant-negative", "C1822773#ent", "<e1>", "expression", "system", "study", "the", "effect", "of", "C0399440#ent", "<e2>", "on", "Wnt", "pathway", "components", "."], "h": {"id": "C1822773", "name": "C1822773#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0399440", "name": "C0399440#ent", "pos": [20, 21]}}
{"token": ["Prostaglandins", "of", "the", "A", "type", "(", "C1868501#ent", "<e1>", ")", "exert", "a", "cytoprotective", "activity", "hyperthermia", "and", "C0042769#ent", "<e2>"], "h": {"id": "C1868501", "name": "C1868501#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [15, 16]}}
{"token": ["Vasculitis", "may", "be", "a", "C0277554#ent", "<e1>", "it", "may", "be", "associated", "with", "C0009782#ent", "<e2>", "infectious", "diseases", "neoplasms", ",", "drug", "assumption", ",", "allograft", "rejection", "so", "on", "."], "h": {"id": "C0277554", "name": "C0277554#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [11, 12]}}
{"token": ["Side", "effects", "not", "significantly", "different", ",", "but", "the", "maprotiline", "group", "showed", "more", "anticholinergic", "side", "effects", "whereas", "the", "C0008845#ent", "<e1>", "group", "showed", "more", "nausea", ",", "increased", "sweating", "and", "C0270697#ent", "<e2>", "."], "h": {"id": "C0008845", "name": "C0008845#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [27, 28]}}
{"token": ["We", "correlated", "follow-up", "information", "from", "138", "patients", "with", "C0004763#ent", "<e1>", "varying", "degrees", "of", "dysplasia", "with", "the", "presence", "of", "C0149745#ent", "<e2>", "."], "h": {"id": "C0004763", "name": "C0004763#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0149745", "name": "C0149745#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "C1825346#ent", "<e1>", "was", "able", "to", "inhibit", "stimulated", "testicular", "testosterone", "secretion", ",", "whereas", "C0002842#ent", "<e2>", "have", "been", "proven", "independent", "modulators", "of", "circulating", "C1825346#ent", "<e1>", "levels", "."], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [14, 15]}}
{"token": ["These", "observations", "have", "been", "confirmed", "by", "confocal", "microscopy", "the", "glucose-stimulated", "expression", "of", "iNOS", ",", "its", "suppression", "by", "C0061355#ent", "<e1>", "and", "its", "reversion", "by", "C0082782#ent", "<e2>", "in", "beta-cells", "."], "h": {"id": "C0061355", "name": "C0061355#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0082782", "name": "C0082782#ent", "pos": [23, 24]}}
{"token": ["C0022956#ent", "<e1>", "is", "associated", "with", "broad", "spectrum", "of", "biological", "effects", "including", "C0072454#ent", "<e2>", "and", "cytotoxic", "activities"], "h": {"id": "C0022956", "name": "C0022956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072454", "name": "C0072454#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "C1539923#ent", "<e1>", "and", "IL-2", "on", "these", "C0022173#ent", "<e2>", "were", "different", "."], "h": {"id": "C1539923", "name": "C1539923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [9, 10]}}
{"token": ["Recently", ",", "the", "two", "genes", "involved", "in", "this", "translocation", "have", "been", "identified", ":", "the", "C1422337#ent", "<e1>", "1p36.3", ",", "and", "the", "C1419697#ent", "<e2>", "3q21", "."], "h": {"id": "C1422337", "name": "C1422337#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419697", "name": "C1419697#ent", "pos": [20, 21]}}
{"token": ["C0764137#ent", "<e1>", "a", "recently", "described", "C2717970#ent", "<e2>", "high", "sequence", "homology", "to", "cathepsin", "L", "other", "members", "of", "the", "papain", "superfamily", "cysteine", "proteinases"], "h": {"id": "C0764137", "name": "C0764137#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [5, 6]}}
{"token": ["With", "the", "recent", "resurgence", "of", "C0041323#ent", "<e1>", "(", "TB", ")", "in", "western", "countries", "the", "incidence", "of", "complicating", "C0032326#ent", "<e2>", "also", "increased", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032326", "name": "C0032326#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "C0016365#ent", "<e1>", "did", "not", "alter", "NTPDase", "and", "C2932861#ent", "<e2>", "activities", "."], "h": {"id": "C0016365", "name": "C0016365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2932861", "name": "C2932861#ent", "pos": [10, 11]}}
{"token": ["We", "retrospectively", "and", "prospectively", "applied", "this", "method", "to", "samples", "from", "48", "patients", "diagnosed", "with", "C0014118#ent", "<e1>", "vascular", "infection", "to", "samples", "from", "100", "controls", "with", "C0014118#ent", "<e1>", "caused", "by", "other", "microorganisms", "."], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [14, 15]}}
{"token": ["The", "mRNA", "expression", "for", "C0376515#ent", "<e1>", "was", "reduced", "by", "C0033228#ent", "<e2>", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [9, 10]}}
{"token": ["Eicosanoids", "are", "synthesized", "by", "C1426677#ent", "<e1>", "through", "the", "action", "of", "C0033551#ent", "<e2>", "and", "lipoxygenase", "enzymes", "and", "serve", "to", "modulate", "the", "proinflammatory", "function", "this", "cell", "as", "part", "of", "the", "lungs", "'", "host", "defense", "mechanism"], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [10, 11]}}
{"token": ["Atypical", "presentation", "seen", "in", "up", "to", "25", "%", "of", "cases", ",", "and", "manifests", "itself", "as", "ocular", "involvement", ",", "encephalopathy", ",", "C0235369#ent", "<e1>", "hepatosplenic", "infection", "endocarditis", "and", "C0029443#ent", "<e2>", "."], "h": {"id": "C0235369", "name": "C0235369#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [26, 27]}}
{"token": ["C2351517#ent", "<e1>", "Lp-PLA(2)", ",", "also", "known", "as", "C1418625#ent", "<e2>", "is", "a", "plasma", "enzyme", "that", "circulates", "bound", "to", "lipoproteins", "."], "h": {"id": "C2351517", "name": "C2351517#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418625", "name": "C1418625#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", ",", "we", "reveal", "the", "possibility", "that", "C1367553#ent", "<e1>", "binds", "to", "the", "cell", "surface", "part", "of", "C1414406#ent", "<e2>", "escaping", "intracellular", "processing", "is", "cleaved", "by", "plasmin", "extracellularly", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414406", "name": "C1414406#ent", "pos": [18, 19]}}
{"token": ["Seventeen", "patients", "had", "C0025290#ent", "<e1>", "8", "had", "systemic", "sepsis", "multi-organ", "involvement", "including", "C0025289#ent", "<e2>", ",", "impaired", "liver", "function", "and", "abnormality", "in", "coagulation", ")", "."], "h": {"id": "C0025290", "name": "C0025290#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [12, 13]}}
{"token": ["C1853261#ent", "<e1>", "also", "transported", "cimetidine", ",", "1-methyl-4-phenylpyridinium", "(", "C1417248#ent", "<e2>", ")", ",", "procainamide", ",", "metformin", ",", "and", "N1-methylnicotinamide", "."], "h": {"id": "C1853261", "name": "C1853261#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417248", "name": "C1417248#ent", "pos": [8, 9]}}
{"token": ["The", "overall", "incidence", "of", "C0221028#ent", "<e1>", "0.7", "%", ",", "the", "incidence", "of", "C3853779#ent", "<e2>", "was", "about", "10", "times", "less", "."], "h": {"id": "C0221028", "name": "C0221028#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C3853779", "name": "C3853779#ent", "pos": [12, 13]}}
{"token": ["The", "C1423814#ent", "<e1>", "do", "not", "simply", "form", "coils", "in", "acidic", "or", "strong", "C3536863#ent", "<e2>", "solutions", "and", "elongated", "structures", "dilute", "alkaline", "solutions", "."], "h": {"id": "C1423814", "name": "C1423814#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [12, 13]}}
{"token": ["Lansoprazole", "and", "C0732569#ent", "<e1>", "provide", "earlier", "and", "better", "symptom", "relief", "than", "the", "other", "C3540020#ent", "<e2>", "some", "studies", "of", "peptic", "ulcer", "treatment", "."], "h": {"id": "C0732569", "name": "C0732569#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540020", "name": "C3540020#ent", "pos": [13, 14]}}
{"token": ["C1416659#ent", "<e1>", "attenuates", "cell", "migration", "affecting", "multiple", "genes", "VEGFR2", "and", "the", "potent", "antimigratory", "C1419946#ent", "<e2>", "."], "h": {"id": "C1416659", "name": "C1416659#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419946", "name": "C1419946#ent", "pos": [13, 14]}}
{"token": ["Treatment", "options", "include", "nasal", "CPAP", "C1426104#ent", "<e1>", ",", "stimulants", "for", "narcolepsy", ",", "sleep", "prolongation", "C0035078#ent", "<e2>", "and", "dopaminergic", "agents", "RLS/PLMS", "."], "h": {"id": "C1426104", "name": "C1426104#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [14, 15]}}
{"token": ["We", "report", "a", "case", "of", "pseudomembranous", "colitis", "developed", "in", "a", "patient", "with", "C0023890#ent", "<e1>", "anti-tuberculosis", "therapy", "with", "rifampicin", "and", "C0022209#ent", "<e2>", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022209", "name": "C0022209#ent", "pos": [19, 20]}}
{"token": ["Intraperitoneal", "(", "C0021171#ent", "<e1>", ")", "administration", "of", "C1825367#ent", "<e2>", "to", "rats", "significantly", "decreased", "PRL", "levels", ",", "and", "this", "effect", "was", "antagonized", "by", "C0021171#ent", "<e1>", "administration", "of", "bicuculline", ",", "an", "antagonist", "of", "the", "GABAA", "receptor"], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1825367", "name": "C1825367#ent", "pos": [7, 8]}}
{"token": ["The", "lingual", "tonsils", "been", "reported", "to", "be", "associated", "with", "variety", "of", "upper", "aerodigestive", "tract", "symptoms", "including", "odynophagia", ",", "dysphagia", ",", "C0013456#ent", "<e1>", ",", "globus", ",", "halitosis", ",", "C0010201#ent", "<e2>", "and", "dyspnea", "."], "h": {"id": "C0013456", "name": "C0013456#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0010201", "name": "C0010201#ent", "pos": [27, 28]}}
{"token": ["The", "results", "presented", "here", "indicate", "that", "C1367452#ent", "<e1>", "have", "divergent", "effects", "on", "C1418597#ent", "<e2>", "production", "in", "hematopoietic", "(", "DC", "and", "macrophages", ")", "and", "nonhematopoietic", "(", "fibroblasts", "and", "EC", ")", "cells", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418597", "name": "C1418597#ent", "pos": [12, 13]}}
{"token": ["NF-kappaB", "translocation", "inhibitor", "and", "C2936824#ent", "<e1>", "PI3", ")", "inhibitor", "LY294002", "decreased", "the", "induction", "of", "C1436224#ent", "<e2>", "by", "sulforaphane", "almost", "to", "baseline", "level", "."], "h": {"id": "C2936824", "name": "C2936824#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1436224", "name": "C1436224#ent", "pos": [14, 15]}}
{"token": ["Mitogen", "activation", "mRNA", "decay", "pathways", "likely", "involves", "specific", "C0014241#ent", "<e1>", ",", "such", "as", "C1825325#ent", "<e2>", ",", "a", "phosphorylation-dependent", "endoribonuclease", "that", "associates", "with", "RasGAP", "in", "dividing", "but", "not", "quiescent", "cells"], "h": {"id": "C0014241", "name": "C0014241#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1825325", "name": "C1825325#ent", "pos": [13, 14]}}
{"token": ["Cyclic", "AMP", "responses", "to", "TSH", ",", "cholera", "toxin", "C0018213#ent", "<e1>", "tested", "in", "a", "medium", "(", "C1823521#ent", "<e2>", ")", "containing", "0.5", "mM", "IBMX", "."], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [15, 16]}}
{"token": ["The", "tumor", "cells", "neither", "rearrangement", "nor", "amplification", "of", "C1333674#ent", "<e1>", "20", "oncogenes", "including", "ras", ",", "myc", ",", "and", "C1705471#ent", "<e2>", "."], "h": {"id": "C1333674", "name": "C1333674#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705471", "name": "C1705471#ent", "pos": [18, 19]}}
{"token": ["These", "results", "indicate", "that", "an", "ELISA", "based", "on", "serum", "antibody", "detection", "to", "C1335798#ent", "<e1>", "could", "be", "developed", "for", "immunodiagnosis", "of", "C0013502#ent", "<e2>", "camels", "."], "h": {"id": "C1335798", "name": "C1335798#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [20, 21]}}
{"token": ["The", "C0003308#ent", "<e1>", "properties", "of", "C0013547#ent", "<e2>", "are", "due", "to", "their", "inhibition", "of", "ergosterol", "biosynthesis"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0013547", "name": "C0013547#ent", "pos": [5, 6]}}
{"token": ["Owing", "to", "the", "high", "broad-spectrum", "C0003308#ent", "<e1>", "clotrimazole", "and", "C0013547#ent", "<e2>", ",", "they", "should", "be", "the", "treatment", "of", "choice", "in", "otomycosis", "and", "can", "be", "used", "safely", "as", "otic", "drops"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [5, 6]}, "relation": "therapeutic_class_of", "t": {"id": "C0013547", "name": "C0013547#ent", "pos": [9, 10]}}
{"token": ["Blood", "leukocytes", "a", "patient", "with", "C1333147#ent", "<e1>", "to", "respond", "to", "stimulation", "with", "phytohemagglutinin", "(", "C0030779#ent", "<e2>", ")", "in", "vitro", "ample", "lymphocytes", "were", "present", "."], "h": {"id": "C1333147", "name": "C1333147#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [14, 15]}}
{"token": ["C0341335#ent", "<e1>", "not", "carry", "a", "worse", "prognosis", "for", "survival", "than", "C0206178#ent", "<e2>", "."], "h": {"id": "C0341335", "name": "C0341335#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0206178", "name": "C0206178#ent", "pos": [10, 11]}}
{"token": ["Estrogen", "receptor", "ER", ")", "and", "C1366500#ent", "<e1>", "PR", ")", "levels", "and", "their", "respective", "dissociation", "constants", "(", "C1839259#ent", "<e2>", ")", "were", "determined", "by", "titration", "assay", "Scatchard", "analyses", "in", "319", "human", "uteri", "."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [16, 17]}}
{"token": ["The", "C1366500#ent", "<e1>", "characterized", "by", "their", "C1839259#ent", "<e2>", "(", "1.40", "nM", ")", "and", "by", "sucrose", "density", "gradient", "."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [6, 7]}}
{"token": ["Defects", "in", "other", "facilitate", "glucose", "transporters", "help", "explain", "Fanconi-Bickel", "syndrome", "C0017922#ent", "<e1>", "Id", "and", "C0011854#ent", "<e2>"], "h": {"id": "C0017922", "name": "C0017922#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "both", "functions", "of", "C1366462#ent", "<e1>", ",", "HAT", "activity", "and", "interaction", "with", "C1413327#ent", "<e2>", ",", "are", "necessary", "for", "targeting", "and", "acetylation", "of", "nucleosomal", "histones"], "h": {"id": "C1366462", "name": "C1366462#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413327", "name": "C1413327#ent", "pos": [15, 16]}}
{"token": ["Yeast", "C1366462#ent", "<e1>", "is", "one", "component", "of", "a", "putative", "adaptor", "complex", "includes", "C1413327#ent", "<e2>", "and", "ADA3", "and", "functionally", "connects", "DNA-bound", "transcriptional", "activators", "with", "general", "transcription", "factors"], "h": {"id": "C1366462", "name": "C1366462#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413327", "name": "C1413327#ent", "pos": [12, 13]}}
{"token": ["In", "this", "review", "we", "address", "the", "following", "questions", ":", "(", "1", ")", "Is", "increased", "C1415651#ent", "<e1>", "activity", "a", "general", "feature", "of", "cardiac", "remodeling", "hypertrophy", "and", "C0018801#ent", "<e2>"], "h": {"id": "C1415651", "name": "C1415651#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [25, 26]}}
{"token": ["However", ",", "the", "causal", "role", "and", "the", "extent", "to", "which", "C1415651#ent", "<e1>", "contributes", "to", "contractile", "dysfunction", "C0018801#ent", "<e2>", "poorly", "understood", "."], "h": {"id": "C1415651", "name": "C1415651#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "saturation", "of", "the", "catalytic", "site", "either", "with", "the", "substrate", ",", "C0041260#ent", "<e1>", ",", "or", "the", "competitive", "inhibitor", ",", "C0049190#ent", "<e2>", ",", "enhances", "binding", "of", "O2", "to", "the", "ferroheme", "moieties", "the", "enzyme", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0049190", "name": "C0049190#ent", "pos": [20, 21]}}
{"token": ["In", "each", "strain", ",", "both", "C0086376#ent", "<e1>", "elicited", "substantial", "antibody", "responses", "that", "were", "cross-reactive", "with", "either", "C1422411#ent", "<e2>", "and", "recognized", "the", "C0086376#ent", "<e1>", "as", "part", "of", "intact", "viral", "Gag", "polyproteins"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422411", "name": "C1422411#ent", "pos": [16, 17]}}
{"token": ["Proteolytic", "scission", "the", "C1412402#ent", "<e1>", ",", "which", "links", "the", "membrane", "skeleton", "the", "C1823138#ent", "<e2>", "band", "3", "induced", "a", "similar", "effect", "."], "h": {"id": "C1412402", "name": "C1412402#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823138", "name": "C1823138#ent", "pos": [12, 13]}}
{"token": ["These", "included", "staff", "medical", "sick", "for", "febrile", "illness", "inpatient", "fevers", "inpatient", "pneumonia", "C1412002#ent", "<e1>", "febrile", "illnesses", "significant", "travel", "history", "sudden", "unexplained", "deaths", "from", "pneumonia/", "adult", "C0035220#ent", "<e2>", "ARDS", ")", "."], "h": {"id": "C1412002", "name": "C1412002#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [25, 26]}}
{"token": ["In", "order", "to", "treat", "a", "C0220994#ent", "<e1>", "patient", "with", "adult-onset", "type-II", "citrullinemia", "C1863844#ent", "<e2>", ")", ",", "sodium", "phenylacetate", "powder", "prepared", "from", "chemical", "reagent", "grade", "phenylacetic", "acid", "Gunma", "University", "Hospital"], "h": {"id": "C0220994", "name": "C0220994#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C1863844", "name": "C1863844#ent", "pos": [12, 13]}}
{"token": ["Impaired", "folate", "metabolism", "from", "primary", "folate", "deficiency", "alcohol", ",", "C0017178#ent", "<e1>", "result", "in", "malabsorption", ",", "single", "nucleotide", "polymorphisms", "increased", "folate", "catabolism", "secondary", "nutrient", "C0268487#ent", "<e2>", "in", "vitamin", "B-6", "vitamin", "B-12", "iron", "arising", "from", "a", "variety", "of", "pathologies", "."], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [23, 24]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "examine", "weather", "prenatal", "stress", "C0341106#ent", "<e1>", "can", "affect", "the", "expression", "of", "GRPR", "in", "the", "C0002707#ent", "<e2>", "."], "h": {"id": "C0341106", "name": "C0341106#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002707", "name": "C0002707#ent", "pos": [21, 22]}}
{"token": ["mRNA", "hybridizable", "to", "a", "C4048300#ent", "<e1>", "induced", "by", "imidazole", "while", "C0022265#ent", "<e2>", "T3", "blocked", "that", "increase", "."], "h": {"id": "C4048300", "name": "C4048300#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [10, 11]}}
{"token": ["This", "approach", "may", "have", "general", "applicability", "forthe", "study", "of", "C0029896#ent", "<e1>", "putatively", "caused", "by", "C0149516#ent", "<e2>", "readily", "demonstrable", "bythe", "usual", "cultural", "or", "immunologic", "techniques"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0149516", "name": "C0149516#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "this", "C1257902#ent", "<e1>", "had", "a", "considerable", "insertional", "mutagenic", "effect", "on", "past", "primate", "C0242965#ent", "<e2>", "."], "h": {"id": "C1257902", "name": "C1257902#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [14, 15]}}
{"token": ["Comparison", "of", "substrate", "specificity", "among", "these", "C0599874#ent", "<e1>", "striking", "differences", "in", "the", "oxidation", "of", "3-methylcatechol", ",", "C0048489#ent", "<e2>", "and", "pyrogallol", "."], "h": {"id": "C0599874", "name": "C0599874#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0048489", "name": "C0048489#ent", "pos": [16, 17]}}
{"token": ["A", "significant", "decrease", "in", "C0001457#ent", "<e1>", "activity", "was", "found", "after", "treatment", "with", "C0034665#ent", "<e2>", "but", "not", "with", "sucralfate", "."], "h": {"id": "C0001457", "name": "C0001457#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [12, 13]}}
{"token": ["C0017661#ent", "<e1>", ",", "interstitial", "pneumopathy", "and", "renal", "and", "C0034069#ent", "<e2>", "major", "complications", "of", "bone", "marrow", "transplantation", "BMT", ")", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [8, 9]}}
{"token": ["C0242339#ent", "<e1>", "patients", "were", "treated", "with", "mg/day", "C0965129#ent", "<e2>", "for", "12", "weeks", "."], "h": {"id": "C0242339", "name": "C0242339#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0965129", "name": "C0965129#ent", "pos": [7, 8]}}
{"token": ["The", "expression", "of", "Nix", "and", "Bcl-xL", "proteins", "decreased", "relative", "to", "C1414968#ent", "<e1>", "GAPDH", ")", "control", "on", "the", "removal", "of", "erythropoietin", "(", "C1414438#ent", "<e2>", ")", "from", "the", "culture", "medium"], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "the", "inhibition", "of", "C0079068#ent", "<e1>", "expression", "by", "C0245514#ent", "<e2>", "may", "depend", "on", "a", "PPAR-independent", "mechanism", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0245514", "name": "C0245514#ent", "pos": [9, 10]}}
{"token": ["This", "is", "mainly", "performed", "by", "a", "member", "of", "the", "ADAM", "(", "a", "disintegrin", "and", "C1334706#ent", "<e1>", ")", "family", "of", "enzymes", ",", "C1569773#ent", "<e2>", "TACE", ",", "ADAM", "17", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1569773", "name": "C1569773#ent", "pos": [21, 22]}}
{"token": ["The", "transactivation", "mechanism", "involves", "the", "release", "of", "TGFalpha", "into", "the", "medium", "through", "activation", "of", "the", "C1334706#ent", "<e1>", "TNFalpha-converting", "enzyme", "(", "also", "known", "as", "C1569773#ent", "<e2>", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1569773", "name": "C1569773#ent", "pos": [23, 24]}}
{"token": ["Chitosan", "(", "CS", ")", "forms", "a", "gel", "in", "solutions", "with", "a", "pH", "above", "12", ",", "and", "the", "C0017237#ent", "<e1>", "occurs", "at", "pH", "of", "about", "9", "in", "10", "%", "C2917660#ent", "<e2>", "."], "h": {"id": "C0017237", "name": "C0017237#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [28, 29]}}
{"token": ["C0264408#ent", "<e1>", "not", "differ", "from", "C0004096#ent", "<e2>", "in", "their", "sweat", "electrolyte", "concentrations", "and", "electrolyte", "losses", "."], "h": {"id": "C0264408", "name": "C0264408#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [5, 6]}}
{"token": ["We", "studied", "the", "effects", "of", "the", "direct", "renin", "inhibitor", "C1879678#ent", "<e1>", "to", "an", "ACE", "inhibitor", "in", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C1879678", "name": "C1879678#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [18, 19]}}
{"token": ["The", "nucleotide", "and", "deduced", "amino", "acid", "of", "the", "P1", "region", "the", "C0017428#ent", "<e1>", "of", "10", "independent", "equine", "rhinitis", "A", "virus", "C0085542#ent", "<e2>", ")", "isolates", "were", "determined", "and", "found", "to", "be", "very", "closely", "related", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085542", "name": "C0085542#ent", "pos": [20, 21]}}
{"token": ["The", "administration", "of", "C0020823#ent", "<e1>", "was", "discontinued", "and", "within", "12", "h", "the", "C0232766#ent", "<e2>", "resolved", "completely", "."], "h": {"id": "C0020823", "name": "C0020823#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0232766", "name": "C0232766#ent", "pos": [12, 13]}}
{"token": ["With", "the", "oligonucleotides", "modified", "at", "C1422270#ent", "<e1>", "and", "G3", "a", "specific", "cleavage", "pattern", "with", "C0284454#ent", "<e2>", "observed", "in", "the", "complementary", "strand", "no", "cleavage", "was", "found", "in", "the", "adduct-bearing", "strand", "."], "h": {"id": "C1422270", "name": "C1422270#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0284454", "name": "C0284454#ent", "pos": [14, 15]}}
{"token": ["No", "cortisol", "measure", "increased", "over", "the", "study", "period", ";", "estimated", "average", "24-hr", "C1413627#ent", "<e1>", "and", "12", "C1426677#ent", "<e2>", "C1413627#ent", "<e1>", "remained", "constant", ",", "whereas", "while", "1", "PM", "C1413627#ent", "<e1>", "declined", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413627", "name": "C1413627#ent", "pos": [12, 13]}}
{"token": ["Both", "single-dose", "challenges", "significantly", "reduced", "the", "amplitude", "of", "RT", ",", "PT", ",", "and", "AT", ",", "but", "only", "C0237406#ent", "<e1>", "significantly", "reduced", "UPDRS", "scores", "for", "rigidity", "and", "C1276035#ent", "<e2>", "."], "h": {"id": "C0237406", "name": "C0237406#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1276035", "name": "C1276035#ent", "pos": [26, 27]}}
{"token": ["The", "D2", "enzyme", "like", "the", "type", "I", "C1416886#ent", "<e1>", ")", "and", "type", "III", "(D3)", "deiodinases", "contains", "a", "C0074299#ent", "<e2>", "(", "SeC", ")", "residue", "(", "residue", "133", "in", "D2", ")", "in", "the", "highly", "conserved", "catalytic", "center"], "h": {"id": "C1416886", "name": "C1416886#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0074299", "name": "C0074299#ent", "pos": [17, 18]}}
{"token": ["Immediately", "after", "cross-linking", ",", "there", "is", "a", "rapid", "influx", "of", "C2936886#ent", "<e1>", ",", "which", "is", "comparable", "with", "concanavalin", "A", "C0524889#ent", "<e2>", "responses", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0524889", "name": "C0524889#ent", "pos": [19, 20]}}
{"token": ["Coadministration", "of", "the", "metabolite", "along", "with", "the", "C0013227#ent", "<e1>", "in", "suppression", "of", "arrhythmias", "at", "lower", "doses", "C0002598#ent", "<e2>", "than", "when", "the", "latter", "was", "administered", "alone", ",", "and", "concentration-response", "analysis", "an", "additive", "antiarrhythmic", "effect"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002598", "name": "C0002598#ent", "pos": [16, 17]}}
{"token": ["We", "have", "found", "that", "a", "complex", "consisting", "of", "a", "type", "I", "C1368110#ent", "<e1>", "and", "a", "C1414032#ent", "<e2>", "associates", "with", "the", "GTPase", "Rac1", "."], "h": {"id": "C1368110", "name": "C1368110#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414032", "name": "C1414032#ent", "pos": [15, 16]}}
{"token": ["To", "report", "an", "unusual", "case", "of", "hypovitaminosis", "A", "with", "C0030353#ent", "<e1>", "flecked", "retina", "regressed", "after", "restoration", "of", "C1510471#ent", "<e2>"], "h": {"id": "C0030353", "name": "C0030353#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1510471", "name": "C1510471#ent", "pos": [17, 18]}}
{"token": ["To", "explain", "some", "of", "the", "conflicting", "results", "with", "C0162823#ent", "<e1>", ",", "the", "proliferation", "induced", "by", "C0066282#ent", "<e2>", "nonanoic", "acid", "both", "considered", "to", "be", "non-sensitisers", ",", "was", "further", "investigated", "."], "h": {"id": "C0162823", "name": "C0162823#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0066282", "name": "C0066282#ent", "pos": [15, 16]}}
{"token": ["The", "budding", "yeast", "homologs", "of", "C1332721#ent", "<e1>", "and", "Polo", "kinase", "referred", "to", "as", "Cdc28", "and", "C1413267#ent", "<e2>", "."], "h": {"id": "C1332721", "name": "C1332721#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413267", "name": "C1413267#ent", "pos": [15, 16]}}
{"token": ["We", "now", "report", "that", "induction", "of", "low", "brain", "inositol", "C0020625#ent", "<e1>", "followed", "by", "C0031923#ent", "<e2>", "did", "not", "cause", "limbic", "seizures", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031923", "name": "C0031923#ent", "pos": [13, 14]}}
{"token": ["C1709995#ent", "<e1>", "prevents", "the", "addition", "of", "C1456390#ent", "<e2>", "barbed", "ends", "during", "a", "seeded", "elongation", "reaction", "and", "suppresses", "dilution-mediated", "depolymerization", "."], "h": {"id": "C1709995", "name": "C1709995#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1456390", "name": "C1456390#ent", "pos": [6, 7]}}
{"token": ["The", "present", "study", "was", "designed", "to", "evaluate", "the", "relationship", "between", "pulmonary", "embolism", "PE", ")", "and", "C0149871#ent", "<e1>", "DVT", ")", "with", "coagulation-fibrinolysis", "markers", "in", "patients", "with", "active", "C0022104#ent", "<e2>", "."], "h": {"id": "C0149871", "name": "C0149871#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [26, 27]}}
{"token": ["Exposure", "to", "bleomycin", "or", "C0205909#ent", "<e1>", "abolished", "the", "characteristic", "biphasic", "response", "C0015008#ent", "<e2>"], "h": {"id": "C0205909", "name": "C0205909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015008", "name": "C0015008#ent", "pos": [11, 12]}}
{"token": ["We", "detected", "the", "point", "mutation", "of", "p53", "at", "codon", "273", "(", "CGT", "to", "C1421391#ent", "<e1>", ")", "in", "one", "C1705347#ent", "<e2>", "and", "two", "ES", "cell", "lines"], "h": {"id": "C1421391", "name": "C1421391#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705347", "name": "C1705347#ent", "pos": [18, 19]}}
{"token": ["A", "66-year-old", "man", "patient", "with", "chronic", "hepatitis", "CH", ")", "C", "and", "complications", "from", "C0009324#ent", "<e1>", "UC", ")", "was", "treated", "with", "C0751599#ent", "<e2>", "(", "IFN-beta", ")", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0751599", "name": "C0751599#ent", "pos": [20, 21]}}
{"token": ["C0162628#ent", "<e1>", "not", "observed", ",", "except", "one", "case", "of", "C1318711#ent", "<e2>"], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1318711", "name": "C1318711#ent", "pos": [9, 10]}}
{"token": ["In", "2003", ",", "we", "reported", "on", "a", "12-yr-old", "boy", "who", "had", "developed", "osteopetrosis", "(", "OPT", ")", "while", "receiving", "pamidronate", "(", "C2698697#ent", "<e1>", ")", "for", "idiopathic", "bone", "pain", "enigmatic", "elevation", "in", "circulating", "C0312399#ent", "<e2>"], "h": {"id": "C2698697", "name": "C2698697#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0312399", "name": "C0312399#ent", "pos": [31, 32]}}
{"token": ["The", "present", "study", "was", "conducted", "to", "determine", "if", "glucagon", "release", "is", "involved", "in", "the", "hyperglycemic", "response", "to", "epinephrine", "and", "C0282210#ent", "<e1>", "in", "the", "fasted", "and", "C0342895#ent", "<e2>", ",", "unanesthetized", "rabbit", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [25, 26]}}
{"token": ["The", "activities", "of", "glycogen", "phosphorylase", "synthase", "during", "infusions", "of", "glucagon", ",", "C0282210#ent", "<e1>", ",", "or", "cyanide", "in", "isolated", "liver", "of", "C0342895#ent", "<e2>", "rats", "submitted", "to", "short-term", "insulin-induced", "hypoglycemia", "IIH", ")", "was", "investigated", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [20, 21]}}
{"token": ["Neutrophil", "counts", "C3813543#ent", "<e1>", "and", "IL-8", "concentration", "in", "C1704942#ent", "<e2>", "obtained", "from", "patients", "with", "DPB", "or", "IPF", "was", "significantly", "higher", "than", "that", "from", "NV", "or", "CP", "."], "h": {"id": "C3813543", "name": "C3813543#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [8, 9]}}
{"token": ["Significantly", "higher", "neutrophil", "percentages", ",", "C3813543#ent", "<e1>", "and", "IL-8", "concentrations", "were", "demonstrated", "in", "the", "C1704942#ent", "<e2>", "from", "DPB", "patients", "than", "from", "chronic", "bronchitis", "CB", ")", "patients", "or", "healthy", "control", "subjects"], "h": {"id": "C3813543", "name": "C3813543#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "it", ",", "we", "examined", "genotype", "patterns", "of", "aldehyde", "dehydrogenase", "C1412335#ent", "<e1>", ")", ",", "alcohol", "dehydrogenase", "ADH2", "and", "ADH3", ")", ",", "and", "C0010763#ent", "<e2>", "CYP2E1", ")", "in", "alcoholic", "pancreatitis", "patients", "."], "h": {"id": "C1412335", "name": "C1412335#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [23, 24]}}
{"token": ["C0008806#ent", "<e1>", "and", "other", "C3542473#ent", "<e2>", "may", "be", "the", "therapy", "of", "choice", "in", "cases", "of", "typhoid", "fever", "by", "organisms", "resistant", "the", "standard", "therapy", "chloramphenicol", "."], "h": {"id": "C0008806", "name": "C0008806#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3542473", "name": "C3542473#ent", "pos": [4, 5]}}
{"token": ["Differential", "diagnosis", "constrictive", "pericarditis", "intestinal", "lymphoma", "Whipple's", "disease", "Crohn's", "disease", "C0275911#ent", "<e1>", "sarcoidosis", "or", "C1290138#ent", "<e2>"], "h": {"id": "C0275911", "name": "C0275911#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "both", "rep", "and", "C3539698#ent", "<e1>", "mutants", "require", "C1449326#ent", "<e2>", "for", "optimal", "growth", ",", "leading", "to", "low", "viability", "of", "the", "triple", "(", "rep", "recA", "dnaK", ")", "mutant", "."], "h": {"id": "C3539698", "name": "C3539698#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1449326", "name": "C1449326#ent", "pos": [10, 11]}}
{"token": ["The", "cortical", "microtubules", "more", "sensitive", "to", "treatment", "with", "microtubule-disrupting", "drugs", "when", "C1416797#ent", "<e1>", "was", "C3889446#ent", "<e2>", ",", "but", "more", "resistant", "when", "C1416797#ent", "<e1>", "was", "eliminated", "in", "cells", "expressing", "C1416797#ent", "<e1>", "RNAi", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1416797", "name": "C1416797#ent", "pos": [11, 12]}}
{"token": ["Severe", "adverse", "reactions", "C0521471#ent", "<e1>", "(", "two", ")", ",", "toxic", "hepatitis", "six", ")", ",", "C1619738#ent", "<e2>", "seven", ")", ",", "and", "four", "deaths", "."], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1619738", "name": "C1619738#ent", "pos": [14, 15]}}
{"token": ["C0012873#ent", "<e1>", "DNMT1", ")", "is", "the", "predominant", "maintenance", "C1334751#ent", "<e2>", "to", "maintain", "DNA", "methylation", "patterns", "in", "mammalian", "cells"], "h": {"id": "C0012873", "name": "C0012873#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334751", "name": "C1334751#ent", "pos": [8, 9]}}
{"token": ["Its", "role", "as", "an", "C1422492#ent", "<e1>", "of", "C3b", "and", "C1412999#ent", "<e2>", "deposited", "on", "self-tissue", "is", "highlighted", "by", "the", "observation", "that", "partial", "deficiency", "of", "CD46", "is", "a", "predisposing", "factor", "hemolytic", "uremic", "syndrome"], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [9, 10]}}
{"token": ["In", "a", "desorption", "process", "81", "%", "of", "rutin", "and", "85", "%", "of", "C0069413#ent", "<e1>", "were", "removed", "from", "the", "C0350056#ent", "<e2>", "surface", "in", "70", "%", "aqueous", "ethanol", "solution", "."], "h": {"id": "C0069413", "name": "C0069413#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0350056", "name": "C0350056#ent", "pos": [18, 19]}}
{"token": ["Subcutaneous", "immunization", "of", "BALB/c", "mice", "C1336933#ent", "<e1>", "expressing", "the", "C0021400#ent", "<e2>", "Lassa", "virus", "N", "gene", "HA-VRP", "or", "N-VRP", ",", "respectively", ")", "induced", "antibody", "responses", "to", "the", "expressed", "protein"], "h": {"id": "C1336933", "name": "C1336933#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [9, 10]}}
{"token": ["Thirty", "patients", "with", "herpes", "zoster", "oticus", "suffering", "from", "C0376175#ent", "<e1>", "admitted", "for", "parenteral", "acyclovir", "and", "C0032950#ent", "<e2>"], "h": {"id": "C0376175", "name": "C0376175#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [15, 16]}}
{"token": ["The", "serum", "concentrations", "of", "febantel", "and", "its", "metabolites", ",", "fenbendazole", ",", "oxfendazole", "and", "C0015821#ent", "<e1>", "determined", "by", "high", "performance", "liquid", "chromatography", "extraction", "with", "C0014996#ent", "<e2>", "."], "h": {"id": "C0015821", "name": "C0015821#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014996", "name": "C0014996#ent", "pos": [23, 24]}}
{"token": ["We", "show", "that", "despite", "this", "difference", ",", "both", "C0031727#ent", "<e1>", "form", "a", "ternary", "complex", "of", "enzyme-", "adenosine", "triphosphate-", "amino", "acid", "accomplish", "C3538970#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3538970", "name": "C3538970#ent", "pos": [21, 22]}}
{"token": ["The", "bacterial", "phosphoenolpyruvate", "C0031727#ent", "<e1>", "PTS", ")", "includes", "a", "collection", "of", "proteins", "that", "accomplish", "C3538970#ent", "<e2>", "phosphoenolpyruvate", "(", "PEP", ")", "to", "a", "sugar", "in", "the", "course", "of", "transport", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3538970", "name": "C3538970#ent", "pos": [14, 15]}}
{"token": ["Two", "anti-inflammatory", "drugs", "used", "to", "treat", "patients", "with", "C0035435#ent", "<e1>", "indomethacin", "and", "C0596007#ent", "<e2>", ",", "can", "directly", "inhibit", "HIV-1", "replication", "and", "may", "provide", "a", "rational", "therapeutic", "approach", "combination", "with", "conventional", "antiviral", "agents"], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0596007", "name": "C0596007#ent", "pos": [12, 13]}}
{"token": ["Eversion", "carotid", "endarterectomy", "e-CEA", ")", "is", "an", "effective", "procedure", "for", "treating", "C0007282#ent", "<e1>", "yet", "it", "has", "not", "been", "reported", "for", "treating", "C2699119#ent", "<e2>", "."], "h": {"id": "C0007282", "name": "C0007282#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2699119", "name": "C2699119#ent", "pos": [21, 22]}}
{"token": ["Raised", "levels", "of", "IL-6", "and", "IL-8", "emerged", "as", "markers", "of", "acute", "as", "well", "as", "C0008679#ent", "<e1>", "while", "increased", "TNF-alpha", "was", "a", "feature", "found", "only", "in", "C0016085#ent", "<e2>"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0016085", "name": "C0016085#ent", "pos": [25, 26]}}
{"token": ["This", "study", "investigated", "among", "smokers", "the", "relationship", "between", "C1413766#ent", "<e1>", "and", "use", "of", "the", "anti-inflammatories", "aspirin", "C0020740#ent", "<e2>", "."], "h": {"id": "C1413766", "name": "C1413766#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [16, 17]}}
{"token": ["This", "is", "surprising", ",", "since", "previous", "studies", "on", "human", "and", "rat", "milk", "have", "shown", "another", "C1332672#ent", "<e1>", ",", "apo-haptocorrin", ",", "to", "be", "the", "dominating", "C1452695#ent", "<e2>"], "h": {"id": "C1332672", "name": "C1332672#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1452695", "name": "C1452695#ent", "pos": [24, 25]}}
{"token": ["The", "levels", "of", "plasma", "triglyceride", "C1439335#ent", "<e1>", "not", "affected", "significantly", "by", "C1412481#ent", "<e2>", "alleles", "."], "h": {"id": "C1439335", "name": "C1439335#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [11, 12]}}
{"token": ["Unexpectedly", ",", "this", "obligate", "'s", "genome", "bears", "hallmarks", "of", "both", "parasitic", "and", "free-living", "microbes", ",", "and", "the", "C0017337#ent", "<e1>", "encoding", "the", "important", "C0086903#ent", "<e2>", "DnaA", "is", "absent", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [22, 23]}}
{"token": ["Mean", "maximum", "percent", "increase", "in", "FEV1", "and", "median", "duration", "of", "bronchodilation", "were", "greater", "with", "C0106575#ent", "<e1>", "than", "with", "C0001927#ent", "<e2>", ",", "but", "the", "differences", "were", "not", "statistically", "significant"], "h": {"id": "C0106575", "name": "C0106575#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [18, 19]}}
{"token": ["The", "favorable", "outcome", "in", "this", "patient", "is", "attributed", "to", "early", "recognition", "of", "the", "C0039082#ent", "<e1>", ",", "which", "might", "occur", "even", "with", "C0012802#ent", "<e2>", "as", "chlorthalidone", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012802", "name": "C0012802#ent", "pos": [21, 22]}}
{"token": ["When", "reserpine", "or", "C0006493#ent", "<e1>", "treatment", "was", "initiated", "after", "the", "onset", "of", "apparent", "C0003864#ent", "<e2>", ",", "it", "was", "still", "possible", "to", "favorably", "influence", "the", "course", "of", "the", "disease", "."], "h": {"id": "C0006493", "name": "C0006493#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [13, 14]}}
{"token": ["Adverse", "changes", "were", "especially", "prominent", "in", "the", "C1824218#ent", "<e1>", "with", "efavirenz", "+", "C0939237#ent", "<e2>", "."], "h": {"id": "C1824218", "name": "C1824218#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0939237", "name": "C0939237#ent", "pos": [12, 13]}}
{"token": ["Methotrexate", "(", "MTX", ")", ",", "an", "C3536950#ent", "<e1>", "of", "folic", "acid", "is", "a", "C1254351#ent", "<e2>", "widely", "used", "in", "the", "treatment", "of", "different", "types", "of", "cancer", "."], "h": {"id": "C3536950", "name": "C3536950#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}}
{"token": ["This", "C3536950#ent", "<e1>", "and", "radiosensitizing", "C1254351#ent", "<e2>", "was", "selected", "in", "an", "attempt", "to", "decrease", "the", "rate", "of", "local", "recurrence", "the", "tumor", "."], "h": {"id": "C3536950", "name": "C3536950#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [5, 6]}}
{"token": ["Posterior", "vitreous", "photographs", "by", "this", "method", "in", "normal", "eyes", "retinitis", "pigmentosa", "C1840452#ent", "<e1>", "and", "preretinal", "macular", "fibrosis", "associated", "with", "macular", "edema", "phakic", "C0235267#ent", "<e2>", "are", "presented", ",", "and", "biomicroscopic", "characteristics", "in", "each", "of", "these", "diseases", "are", "discussed", "."], "h": {"id": "C1840452", "name": "C1840452#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [22, 23]}}
{"token": ["Weakly", "positive", "reaction", "confined", "to", "a", "few", "cell", "clusters", ",", "was", "observed", "in", "one", "smear", "of", "a", "benign", "C0038358#ent", "<e1>", "one", "smear", "of", "C2919828#ent", "<e2>"], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2919828", "name": "C2919828#ent", "pos": [23, 24]}}
{"token": ["Out", "of", "the", "cutaneous", "C0004623#ent", "<e1>", "highest", "numbers", "of", "mast", "cells", "seen", "in", "C0023343#ent", "<e2>", "(", "44/mm2", ")", "while", "in", "lupus", "vulgaris", "were", "much", "less", "(", "37/mm2", ")", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [13, 14]}}
{"token": ["Perceptual", "illusions", "and", "C0042818#ent", "<e1>", "reported", "by", "most", "C0154723#ent", "<e2>", "sufferers", "and", "those", "with", "frequent", "headaches", "."], "h": {"id": "C0042818", "name": "C0042818#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0154723", "name": "C0154723#ent", "pos": [8, 9]}}
{"token": ["betaI-spectrin", "binds", "specifically", "to", "C3890909#ent", "<e1>", "but", "not", "to", "the", "C3890909#ent", "<e1>", "related", "proteins", "C1332750#ent", "<e1>", "and", "CRP2", "or", "to", "other", "LIM", "domain", "proteins", "."], "h": {"id": "C3890909", "name": "C3890909#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332750", "name": "C1332750#ent", "pos": [14, 15]}}
{"token": ["Associated", "alopecia", "cutaneous", "hyperpigmentation", "C0221260#ent", "<e1>", "loss", "of", "nails", "consistent", "with", "diagnosis", "of", "C0282207#ent", "<e2>"], "h": {"id": "C0221260", "name": "C0221260#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0282207", "name": "C0282207#ent", "pos": [13, 14]}}
{"token": ["A", "43-year-old", "woman", "with", "a", "history", "of", "systemic", "lupus", "erythematosus", "severe", "diarrhea", ",", "generalized", "gastrointestinal", "polyposis", ",", "pigmentation", ",", "and", "C0221260#ent", "<e1>", ",", "which", "were", "typical", "of", "C0282207#ent", "<e2>"], "h": {"id": "C0221260", "name": "C0221260#ent", "pos": [20, 21]}, "relation": "manifestation_of", "t": {"id": "C0282207", "name": "C0282207#ent", "pos": [27, 28]}}
{"token": ["The", "lymphocyte", "transformation", "test", "LTT", ")", "confirms", "the", "classical", "concept", "that", "Novocain", "is", "three", "times", "as", "potent", "as", "C0699094#ent", "<e1>", "as", "a", "C0034541#ent", "<e2>"], "h": {"id": "C0699094", "name": "C0699094#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0034541", "name": "C0034541#ent", "pos": [22, 23]}}
{"token": ["C0270860#ent", "<e1>", "BM", ")", "and", "hemiplegic", "migraine", "clinically", "distinct", "subtypes", "of", "C0149931#ent", "<e2>", "with", "aura", ",", "however", "they", "do", "share", "clinical", "features", "and", "it", "is", "possible", "they", "may", "share", "genetic", "bases"], "h": {"id": "C0270860", "name": "C0270860#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [11, 12]}}
{"token": ["We", "have", "investigated", "a", "Japanese", "patient", "with", "C0752252#ent", "<e1>", "was", "previously", "reported", "as", "C0342790#ent", "<e2>"], "h": {"id": "C0752252", "name": "C0752252#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342790", "name": "C0342790#ent", "pos": [13, 14]}}
{"token": ["The", "crosstalk", "of", "insulin", ",", "C1366557#ent", "<e1>", "and", "TNFalpha", "signaling", "pathways", "regulate", "bile", "acid", "synthesis", "and", "lipid", "homeostasis", "C0011849#ent", "<e2>", ",", "fatty", "liver", "disease", "and", "liver", "fibrosis"], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [18, 19]}}
{"token": ["Particle-free", "supernatants", "(", "225,000", "x", "g", ")", "C0025517#ent", "<e1>", "AMP", "alone", "slowly", ",", "but", "C0672045#ent", "<e2>", "active", "when", "ATP", "was", "added", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0672045", "name": "C0672045#ent", "pos": [14, 15]}}
{"token": ["Unlike", "C0012525#ent", "<e1>", "or", "codeine", ",", "C0282221#ent", "<e2>", "does", "not", "appear", "to", "exert", "opiate", "activity", "man", "at", "normal", "therapeutic", "doses"], "h": {"id": "C0012525", "name": "C0012525#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0282221", "name": "C0282221#ent", "pos": [6, 7]}}
{"token": ["These", "observations", "suggest", "that", "patients", "with", "the", "C0349653#ent", "<e1>", "a", "progressive", "tapetoretinal", "degenerative", "disorder", "the", "C0035334#ent", "<e2>", "defined", "alterations", "in", "the", "electroretinogram", "."], "h": {"id": "C0349653", "name": "C0349653#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [15, 16]}}
{"token": ["Likewise", ",", "the", "incidence", "and", "severity", "of", "C1533847#ent", "<e1>", "greater", "in", "WT", "mice", "GW0742", "compared", "with", "C4284124#ent", "<e2>"], "h": {"id": "C1533847", "name": "C1533847#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [16, 17]}}
{"token": ["These", "five", "genes", ",", "along", "with", "matrix", "metalloproteinase", "9", "a", "C0162745#ent", "<e1>", "found", "to", "be", "increased", "in", "several", "C0024115#ent", "<e2>", "are", "known", "to", "control", "matrix", "production", "and", "cell", "proliferation", "humans", "and", "animals", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [18, 19]}}
{"token": ["Strains", "with", "C0268487#ent", "<e1>", "in", "the", "NER", "genes", "RAD1", ",", "C2986918#ent", "<e2>", ",", "RAD4", ",", "and", "RAD10", "had", "low", "levels", "of", "cross-link-induced", "recombination", "but", "higher", "mutation", "frequencies", "than", "repair-proficient", "cells", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2986918", "name": "C2986918#ent", "pos": [10, 11]}}
{"token": ["Pathogenesis", "of", "this", "has", "been", "variably", "thought", "to", "be", "due", "to", "C0022806#ent", "<e1>", ",", "insufficient", "dialysis", ",", "amyloidosis", ",", "chronic", "acidosis", "or", "C0020502#ent", "<e2>", "."], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020502", "name": "C0020502#ent", "pos": [22, 23]}}
{"token": ["Pretreatment", "with", "either", "the", "converting", "enzyme", "inhibitor", "teprotide", ",", "or", "the", "C0085387#ent", "<e1>", "indomethacin", ",", "failed", "to", "normalize", "the", "response", "to", "C1424250#ent", "<e2>", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1424250", "name": "C1424250#ent", "pos": [21, 22]}}
{"token": ["The", "rat", "liver", "C0070788#ent", "<e1>", "cDNA", "and", "the", "murine", "C1418456#ent", "<e2>", "been", "cloned", "and", "characterized", "."], "h": {"id": "C0070788", "name": "C0070788#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418456", "name": "C1418456#ent", "pos": [9, 10]}}
{"token": ["Hepatocytes", "have", "a", "second", "pathway", "for", "the", "synthesis", "of", "phosphatidylcholine", ",", "a", "stepwise", "methylation", "of", "phosphatidylethanolamine", ",", "catalyzed", "by", "C0070788#ent", "<e1>", "encoded", "by", "the", "C1418456#ent", "<e2>"], "h": {"id": "C0070788", "name": "C0070788#ent", "pos": [19, 20]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418456", "name": "C1418456#ent", "pos": [24, 25]}}
{"token": ["The", "purified", "C0029408#ent", "<e1>", "contained", "pyridoxal", "5'-phosphate", "catalyzed", "the", "formation", "of", "L-cysteine", "and", "C0000979#ent", "<e2>", "from", "O-acetyl-L-serine", "and", "sulfide", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [13, 14]}}
{"token": ["The", "mitochondrial", "pyruvate", "dehydrogenase", "complex", "C1418706#ent", "<e1>", ")", "is", "inactivated", "in", "many", "tissues", "during", "starvation", "and", "C0011847#ent", "<e2>", "."], "h": {"id": "C1418706", "name": "C1418706#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [16, 17]}}
{"token": ["The", "pyruvate", "dehydrogenase", "complex", "C1418706#ent", "<e1>", ")", "is", "inactivated", "in", "many", "tissues", "during", "starvation", "and", "C0011847#ent", "<e2>", "to", "conserve", "three-carbon", "compounds", "for", "gluconeogenesis", "."], "h": {"id": "C1418706", "name": "C1418706#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [15, 16]}}
{"token": ["A", "retrospective", "study", "737", "consecutive", "necropsies", "yielded", "15", "cases", "of", "C0035312#ent", "<e1>", "of", "the", "C0029128#ent", "<e2>", "an", "incidence", "of", "20", "-", "4", "cases", "per", "thousand", "."], "h": {"id": "C0035312", "name": "C0035312#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0029128", "name": "C0029128#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "the", "best", "imaging", "procedure", "diagnosing", "C0035312#ent", "<e1>", "of", "the", "C0029128#ent", "<e2>"], "h": {"id": "C0035312", "name": "C0035312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029128", "name": "C0029128#ent", "pos": [11, 12]}}
{"token": ["We", "herein", "report", "a", "new", "and", "simple", "cloning", "approach", "to", "an", "efficient", "and", "robust", "construction", "of", "recombinant", "C0042720#ent", "<e1>", "on", "the", "mating-assisted", "C1516876#ent", "<e2>", "integrated", "cloning", "(", "MAGIC", ")", "strategy", "."], "h": {"id": "C0042720", "name": "C0042720#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [22, 23]}}
{"token": ["Since", "recombination", "requires", "the", "coexistence", "of", "two", "C0042720#ent", "<e1>", "these", "results", "suggest", "that", "co-infection", "by", "C1516876#ent", "<e2>", "distinct", "strains", "may", "be", "a", "more", "important", "aspect", "of", "HSV-1", "epidemiology", "than", "previously", "realized", "."], "h": {"id": "C0042720", "name": "C0042720#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [15, 16]}}
{"token": ["At", "C1424742#ent", "<e1>", ",", "NT3-mRNA", "labeling", "was", "below", "detection", "level", "and", "C1417863#ent", "<e2>", "mRNA", "expression", "was", "lower", "than", "at", "prior", "stages", "."], "h": {"id": "C1424742", "name": "C1424742#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417863", "name": "C1417863#ent", "pos": [11, 12]}}
{"token": ["A", "functional", "MEK-ERK", "pathway", "is", "an", "important", "requirement", "for", "CB1-mediated", "C3274819#ent", "<e1>", "induction", "as", "blockade", "of", "MEK", "signaling", "by", "C0755562#ent", "<e2>", "reduces", "both", "basal", "and", "CB1-mediated", "activation", "of", "C3274819#ent", "<e1>", "."], "h": {"id": "C3274819", "name": "C3274819#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [19, 20]}}
{"token": ["The", "prenylated", "Rab", "acceptor", "C3669212#ent", "<e1>", ")", "1", "is", "a", "protein", "that", "binds", "C0018296#ent", "<e2>", "inhibits", "their", "removal", "from", "the", "membrane", "by", "GDI", "."], "h": {"id": "C3669212", "name": "C3669212#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [13, 14]}}
{"token": ["The", "Ca(2", "+", ")", "channels", "underlying", "bursting", "are", "located", "primarily", "near", "the", "C0702216#ent", "<e1>", ",", "and", "the", "amplitude", "of", "C0001477#ent", "<e2>", "currents", "correlates", "with", "the", "strength", "of", "bursting", "across", "cells", "."], "h": {"id": "C0702216", "name": "C0702216#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "indicate", "that", "C1335208#ent", "<e1>", "functions", "as", "a", "transcriptional", "corepressor", "C1414463#ent", "<e2>", "in", "vitro", "in", "vivo", "and", "that", "its", "heteromerization", "with", "REA", "acts", "as", "a", "novel", "mechanism", "to", "limit", "its", "corepressor", "activity"], "h": {"id": "C1335208", "name": "C1335208#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414463", "name": "C1414463#ent", "pos": [11, 12]}}
{"token": ["C0120726#ent", "<e1>", "has", "been", "shown", "to", "be", "very", "effective", "against", "multiple", "drug", "resistant", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0120726", "name": "C0120726#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [13, 14]}}
{"token": ["To", "evaluate", "mefloquine", "versus", "C0120726#ent", "<e1>", "in", "children", "suffering", "from", "acute", "uncomplicated", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0120726", "name": "C0120726#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [12, 13]}}
{"token": ["Phenobarbital", "induced", "the", "de", "novo", "synthesis", "of", "a", "C0001214#ent", "<e1>", "Mr", "=", "51,000", ",", "whereas", "C0053490#ent", "<e2>", "induced", "the", "de", "novo", "synthesis", "of", "a", "C0001214#ent", "<e1>", "Mr", "=", "55,000", "."], "h": {"id": "C0001214", "name": "C0001214#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0053490", "name": "C0053490#ent", "pos": [15, 16]}}
{"token": ["Further", "studies", "revealed", "that", "C1419409#ent", "<e1>", "positively", "regulates", "the", "ability", "of", "SF", "to", "stimulate", "C2986464#ent", "<e2>", "cell", "protection"], "h": {"id": "C1419409", "name": "C1419409#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [14, 15]}}
{"token": ["Ras", ",", "C1419409#ent", "<e1>", "and", "RalA", "modulate", "SF", "stimulation", "of", "C2986464#ent", "<e2>", "in", "part", ",", "by", "regulating", "IkappaB", "kinase", "(IKK)-beta", "kinase", "activity"], "h": {"id": "C1419409", "name": "C1419409#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [10, 11]}}
{"token": ["The", "ability", "of", "C1419409#ent", "<e1>", "to", "stimulate", "C2986464#ent", "<e2>", "not", "due", "to", "the", "classical", "C1419409#ent", "<e1>", "--", ">", "MEK1/2", "--", ">", "ERK1/2", "pathway", "."], "h": {"id": "C1419409", "name": "C1419409#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [7, 8]}}
{"token": ["Consistent", "with", "observation", ",", "we", "found", "that", "a", "mutation", "within", "the", "Leu-X-Cys-X-Glu", "motif", "of", "C1419288#ent", "<e1>", "resulted", "in", "loss", "of", "to", "precipitate", "C2984536#ent", "<e2>", ",", "while", "RB-", "and", "TBP-binding", "activities", "were", "retained", "."], "h": {"id": "C1419288", "name": "C1419288#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2984536", "name": "C2984536#ent", "pos": [22, 23]}}
{"token": ["Since", "this", "C3265462#ent", "<e1>", "had", "properties", "similar", "to", "C0108471#ent", "<e2>", "the", "ability", "of", "cathepsin", "A", "to", "metabolize", "AI", "was", "studied", "."], "h": {"id": "C3265462", "name": "C3265462#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [8, 9]}}
{"token": ["This", "compound", "was", "found", "to", "inhibit", "the", "C0055673#ent", "<e1>", "the", "26S", "proteasome", "similar", "levels", "to", "known", "inhibitor", "clasto-lactacystin", "beta-lactone", "C0764177#ent", "<e2>", ")", "."], "h": {"id": "C0055673", "name": "C0055673#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0764177", "name": "C0764177#ent", "pos": [19, 20]}}
{"token": ["Continuous", "application", "the", "second", "generation", "bisphosphonate", ",", "C0356588#ent", "<e1>", ",", "leads", "to", "an", "increased", "density", "of", "vertebral", "bodies", "C0521170#ent", "<e2>", "patients", "up", "to", "four", "years", "and", "a", "decreased", "frequency", "of", "new", "vertebral", "fractures"], "h": {"id": "C0356588", "name": "C0356588#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0521170", "name": "C0521170#ent", "pos": [18, 19]}}
{"token": ["Using", "activation", "loop-specific", "C0085536#ent", "<e1>", "we", "did", "not", "detect", "phospho-JAK1", "and", "phospho-JAK2", "after", "C0105421#ent", "<e2>", "stimulation", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [13, 14]}}
{"token": ["To", "identify", "signaling", "molecules", "in", "B", "cell", "antigen", "receptor", "pathways", ",", "we", "used", "the", "immature", "B", "cell", "line", "WEHI-231", ",", "to", "investigate", "C0085536#ent", "<e1>", "PTP", ")", "whose", "expression", "was", "modulated", "by", "C0105421#ent", "<e2>", "ligation", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [31, 32]}}
{"token": ["No", "genetic", "risk", "revealed", "by", "the", "assay", "in", "the", "cytostatics", "C0058948#ent", "<e1>", ",", "Penberol", ",", "Butocin", ",", "and", "C0057103#ent", "<e2>", "."], "h": {"id": "C0058948", "name": "C0058948#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0057103", "name": "C0057103#ent", "pos": [18, 19]}}
{"token": ["Extracts", "from", "the", "coral", "contained", "no", "detectable", "C3540754#ent", "<e1>", "(", "PGAs", ",", "PGBs", ",", "PGEs", ",", "or", "C1412326#ent", "<e2>", ")", "."], "h": {"id": "C3540754", "name": "C3540754#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412326", "name": "C1412326#ent", "pos": [17, 18]}}
{"token": ["GlNCED1", "was", "evolutionary", "closely", "related", "to", "Arabidopsis", "thaliana", "C1706552#ent", "<e1>", "whereas", "GlNCED2", "showed", "highest", "homology", "to", "tomato", "C1417052#ent", "<e2>", "and", "A.", "thaliana", "NCED3", "."], "h": {"id": "C1706552", "name": "C1706552#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417052", "name": "C1417052#ent", "pos": [17, 18]}}
{"token": ["This", "feasibility", "study", "undertaken", "to", "compare", "the", "sensitivity", "of", "Tc-99m", "C0011806#ent", "<e1>", "with", "that", "of", "Tc-99m", "human", "immunoglobulin", "G", "diagnose", "C0009324#ent", "<e2>", "and", "to", "explore", "its", "possible", "role", "in", "disease", "follow-up"], "h": {"id": "C0011806", "name": "C0011806#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [20, 21]}}
{"token": ["The", "deduced", "C1333365#ent", "<e1>", "amino", "acid", "sequence", "similarity", "to", "C0005270#ent", "<e2>", "from", "a", "variety", "of", "organisms", "."], "h": {"id": "C1333365", "name": "C1333365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005270", "name": "C0005270#ent", "pos": [9, 10]}}
{"token": ["C0016282#ent", "<e1>", "the", "most", "potent", "TRPV1", "C2987634#ent", "<e2>", "reported", "herein", ",", "retains", "the", "cyclooxygenase", "(", "COX", ")", "inhibition", "properties", "of", "the", "parent", "compound", "flufenamic", "acid"], "h": {"id": "C0016282", "name": "C0016282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}}
{"token": ["Tel2", "bound", "to", "Tti1", "interacts", "with", "various", "C0089793#ent", "<e1>", "kinases", "including", "Tra1", ",", "Tra2", "and", "C2986918#ent", "<e2>", ",", "as", "well", "as", "Tor1", "and", "Tor2", "."], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2986918", "name": "C2986918#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "report", "that", "both", "saturated/monounsaturated", "NAEs", "and", "anandamide", "(", "20:4(n-6", ")", "C3272370#ent", "<e1>", ")", "stimulate", "cannabinoid-receptor-independent", "ERK", "phosphorylation", "and", "C1333571#ent", "<e2>", "transcriptional", "activity", "mouse", "epidermal", "JB6", "cells", "."], "h": {"id": "C3272370", "name": "C3272370#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [20, 21]}}
{"token": ["The", "potent", "inflammability", "of", "B-LPS", "shown", "in", "the", "present", "study", "indicates", "that", "it", "is", "one", "of", "the", "effective", "C0035064#ent", "<e1>", "to", "induce", "C0031099#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031099", "name": "C0031099#ent", "pos": [22, 23]}}
{"token": ["It", "has", "been", "proposed", "that", "Bacteroides", "gingivalis", "Actinomyces", "viscosus", "most", "important", "C0035064#ent", "<e1>", "to", "pathogenesis", "of", "the", "C0031099#ent", "<e2>", "and", "gingivitis", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031099", "name": "C0031099#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "it", "is", "known", "that", "C1420234#ent", "<e1>", "is", "phosphorylated", "and", "inhibited", "by", "C1514550#ent", "<e2>", "protein", "kinase", "A", "."], "h": {"id": "C1420234", "name": "C1420234#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [13, 14]}}
{"token": ["However", ",", "in", "the", "C1260386#ent", "<e1>", "and", "ascorbate", "(", "nonthiol", ")", "MCO", "system", ",", "C0393754#ent", "<e2>", "was", "not", "sacrificially", "degraded", ",", "and", "indeed", "accelerated", "the", "formation", "of", "DNA", "strand", "breaks"], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0393754", "name": "C0393754#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "diagnosed", "hypertension", "and", "currently", "being", "prescribed", "C0003364#ent", "<e1>", "with", "four", "general", "practices", "comparing", "patients", "also", "prescribed", "C0080151#ent", "<e2>", "(", "exposed", ")", "to", "those", "not", "prescribed", "C0080151#ent", "<e2>", "(", "unexposed", ")", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [18, 19]}}
{"token": ["To", "ascertain", "whether", "a", "coding", "mutation", "Ile93Met", ")", "in", "C0164005#ent", "<e1>", "UCH-L1", ")", "gene", "plays", "a", "role", "in", "idiopathic", "Parkinson's", "disease", "C3540529#ent", "<e2>", ")", "."], "h": {"id": "C0164005", "name": "C0164005#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540529", "name": "C3540529#ent", "pos": [21, 22]}}
{"token": ["Three", "cases", "of", "iatrogenic", "C0014860#ent", "<e1>", "presented", "from", "a", "series", "of", "1275", "panendoscopies", "of", "the", "C1698481#ent", "<e2>", "rigid", "esophoscopy", "(", "0.24", "%", ")", "."], "h": {"id": "C0014860", "name": "C0014860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1698481", "name": "C1698481#ent", "pos": [15, 16]}}
{"token": ["One", "of", "the", "C0086376#ent", "<e1>", "identified", "is", "the", "C0767546#ent", "<e2>", ",", "an", "adaptor", "protein", "SH3", "domains"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0767546", "name": "C0767546#ent", "pos": [8, 9]}}
{"token": ["Consistent", "with", "solubility", ",", "this", "bovine", "C1419185#ent", "<e1>", "paralogue", "lacks", "the", "C-terminal", "transmembrane", "span", "of", "the", "long", "form", "these", "C0086376#ent", "<e2>", "."], "h": {"id": "C1419185", "name": "C1419185#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["This", "mechanism", "represents", "a", "hallmark", "of", "FM", "and", "many", "other", "chronic", "pain", "syndromes", "including", "irritable", "bowel", "syndrome", "C0039494#ent", "<e1>", "migraine", ",", "and", "C0024031#ent", "<e2>"], "h": {"id": "C0039494", "name": "C0039494#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [22, 23]}}
{"token": ["Patients", "suffering", "chronic", "pain", "from", "deep", "tissues", "such", "as", "C0039494#ent", "<e1>", "fibromyalgia", ",", "or", "C0024031#ent", "<e2>", "often", "complain", "of", "pain", "and", "tenderness", "in", "various", "parts", "of", "the", "body", "."], "h": {"id": "C0039494", "name": "C0039494#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [14, 15]}}
{"token": ["This", "mechanism", "represents", "a", "hallmark", "of", "fibromyalgia", "and", "many", "other", "chronic", "pain", "syndromes", "including", "irritable", "bowel", "syndrome", "C0039494#ent", "<e1>", "migraine", ",", "and", "C0024031#ent", "<e2>"], "h": {"id": "C0039494", "name": "C0039494#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [22, 23]}}
{"token": ["L-NNA", "and", "indomethacin", "were", "less", "effective", "than", "denudation", "in", "arteries", "from", "pregnant", "and", "nonpregnant", "animals", ",", "which", "suggests", "that", "pregnancy", "C2712370#ent", "<e1>", "thromboxane", "contraction", "endothelium-dependent", "mechanisms", "other", "than", "NO", "and", "C0356622#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [30, 31]}}
{"token": ["C0040676#ent", "<e1>", "also", "been", "identified", "as", "a", "protective", "antigen", "C0036329#ent", "<e2>", "."], "h": {"id": "C0040676", "name": "C0040676#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036329", "name": "C0036329#ent", "pos": [9, 10]}}
{"token": ["Astrocyte", "responses", "to", "histamine", "and", "C0006945#ent", "<e1>", "were", "compared", "with", "responses", "elicited", "by", "alpha1-adrenergic", "and", "C1333711#ent", "<e2>"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333711", "name": "C1333711#ent", "pos": [15, 16]}}
{"token": ["An", "C4289590#ent", "<e1>", "of", "Hegfl", "in", "the", "uterus", "by", "blastocyst-derived", "C1704816#ent", "<e2>", "is", "also", "a", "possibility", "."], "h": {"id": "C4289590", "name": "C4289590#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704816", "name": "C1704816#ent", "pos": [10, 11]}}
{"token": ["C3714798#ent", "<e1>", ",", "the", "predominant", "cytochrome", "P450", "C0010762#ent", "<e2>", ")", "expressed", "in", "human", "liver", "and", "intestine", ",", "contributes", "to", "the", "metabolism", "of", "approximately", "half", "the", "drugs", "in", "clinical", "use", "today", "."], "h": {"id": "C3714798", "name": "C3714798#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [7, 8]}}
{"token": ["In", "our", "previous", "study", ",", "a", "rat", "C1334043#ent", "<e1>", "of", "human", "nonmuscle", "myosin", "heavy", "chain-B", "C3273546#ent", "<e2>", ")", "was", "identified", "by", "mRNA", "differential", "display", "comparing", "of", "transformed", "against", "nontransformed", "Rat", "6", "cells", "overexpressing", "mutant", "p53val135", "gene", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273546", "name": "C3273546#ent", "pos": [15, 16]}}
{"token": ["It", "also", "reversed", "the", "effects", "of", "systemically", "administered", "C0021246#ent", "<e1>", "on", "gastric", "acid", "and", "C0149745#ent", "<e2>", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0149745", "name": "C0149745#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "was", "performed", "to", "test", "the", "potential", "of", "C0525678#ent", "<e1>", "as", "a", "disease-modifying", "agent", "in", "multiple", "system", "atrophy", "C0000294#ent", "<e2>", ")", "using", "a", "transgenic", "mouse", "previously", "described", "by", "our", "group", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000294", "name": "C0000294#ent", "pos": [20, 21]}}
{"token": ["Several", "members", "of", "the", "C2984597#ent", "<e1>", "(", "a", "disintegrin", "and", "C1418385#ent", "<e2>", ")", "family", "of", "proteins", "have", "been", "implicated", "in", "biological", "processes", "from", "fertilization", "to", "myoblast", "fusion", "neural", "cell", "fate", "determination", "."], "h": {"id": "C2984597", "name": "C2984597#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418385", "name": "C1418385#ent", "pos": [10, 11]}}
{"token": ["C2984597#ent", "<e1>", "(", "a", "disintegrin", "and", "C1418385#ent", "<e2>", ")", "family", "proteins", "important", "roles", "in", "animal", "development", "pathogenesis", "."], "h": {"id": "C2984597", "name": "C2984597#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418385", "name": "C1418385#ent", "pos": [6, 7]}}
{"token": ["At5g49980", "is", "previously", "uncharacterized", "and", "encodes", "auxin", "signaling", "C1257945#ent", "<e1>", "one", "of", "five", "C4277608#ent", "<e2>", "of", "TIR1", "in", "the", "Arabidopsis", "genome", "."], "h": {"id": "C1257945", "name": "C1257945#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [13, 14]}}
{"token": ["C0006462#ent", "<e1>", ",", "a", "partial", "5-HT(1A", ")", "C2987634#ent", "<e2>", ",", "has", "been", "reported", "to", "produce", "anxiolytic-like", "actions", "in", "the", "clinic", ",", "but", "has", "had", "mixed", "results", "in", "experimental", "tests", "anxiety", "using", "animal", "subjects"], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}}
{"token": ["UDP-glucuronosyltransferase", "1A6", "C1421330#ent", "<e1>", ")", "is", "a", "major", "C4284131#ent", "<e2>", "contributing", "to", "the", "glucuronidation", "of", "small", "phenolic", "compounds", "."], "h": {"id": "C1421330", "name": "C1421330#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4284131", "name": "C4284131#ent", "pos": [8, 9]}}
{"token": ["Both", "an", "A", "to", "G", "transition", "nucleotide", "541", "T181", "A", ")", "and", "an", "A", "to", "C", "transversion", "nucleotide", "552", "R184S", ")", "occurred", "in", "exon", "1", "the", "C1421330#ent", "<e1>", "(", "UGT1F", ")", "gene", "at", "the", "C4284131#ent", "<e2>"], "h": {"id": "C1421330", "name": "C1421330#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C4284131", "name": "C4284131#ent", "pos": [34, 35]}}
{"token": ["Actinomycin", "D", "cycloheximide", "did", "not", "affect", "the", "induction", "of", "C1421330#ent", "<e1>", "by", "beta-naphthoflavone", ",", "but", "suppressed", "that", "of", "ketoprofen", "C4284131#ent", "<e2>", "."], "h": {"id": "C1421330", "name": "C1421330#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4284131", "name": "C4284131#ent", "pos": [19, 20]}}
{"token": ["In", "conclusion", ",", "seven", "3-MeSO(2)-PCBs", "and", "4-MeSO(2)-CB101", "induce", "both", "UGT2B1", "and", "C1421330#ent", "<e1>", ",", "and", "4-MeSO(2)-CB149", "induces", "C4284131#ent", "<e2>", "2B1", "."], "h": {"id": "C1421330", "name": "C1421330#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4284131", "name": "C4284131#ent", "pos": [17, 18]}}
{"token": ["Drug", "fever", "the", "C0015967#ent", "<e1>", "response", "to", "a", "C0013227#ent", "<e2>", "without", "cutaneous", "manifestations", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}}
{"token": ["A", "41-year-old", "woman", "with", "C0024141#ent", "<e1>", "presented", "with", "symptoms", "of", "C0027726#ent", "<e2>"], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [10, 11]}}
{"token": ["C3850056#ent", "<e1>", "reduced", "turnover", "of", "the", "C0013227#ent", "<e2>", ",", "production", "of", "the", "glutathione", "adduct", "irreversible", "binding", "and", "cytotoxicity", "but", "inhibited", "glutathione", "depletion", "selectively", "."], "h": {"id": "C3850056", "name": "C3850056#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [6, 7]}}
{"token": ["In", "particular", "we", "have", "shown", "that", "the", "molecular", "weight", "fucosylated", "C0061642#ent", "<e1>", "appears", "to", "be", "abnormally", "high", "in", "the", "untreated", "C3890176#ent", "<e2>", "lesion", ",", "possibly", "reflecting", "an", "increased", "degree", "of", "branching", "."], "h": {"id": "C0061642", "name": "C0061642#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3890176", "name": "C3890176#ent", "pos": [20, 21]}}
{"token": ["This", "review", "represents", "an", "examination", "of", "four", "groups", "of", "C0524851#ent", "<e1>", "namely", "the", "sphingolipidoses", ",", "the", "C0282525#ent", "<e2>", "the", "neuronal", "ceroid", "lipofuscinoses", "and", "the", "sialidoses/sialuria", "complex", "."], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0282525", "name": "C0282525#ent", "pos": [16, 17]}}
{"token": ["However", ",", "in", "Malawi", "lytic", "cocktail", "and", "use", "of", "C0003364#ent", "<e1>", "such", "as", "C0020223#ent", "<e2>", "and", ",", "anticonvulsants", "such", "as", "Valium", "are", "currently", "in", "use", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [13, 14]}}
{"token": ["Treatment", "with", "the", "C0003364#ent", "<e1>", "losartan", "(", "25", "mg/kg", "per", "day", ")", "or", "C0020223#ent", "<e2>", "(", "15", "mg/kg", "per", "day", ")", "inhibited", "this", "upregulation", "of", "mRNA", "levels", "and", "activity", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [13, 14]}}
{"token": ["On", "the", "both", "fMLP-", "and", "PMA-induced", "chemiluminescence", ",", "the", "priming", "effect", "C0123047#ent", "<e1>", "was", "further", "enhanced", "by", "the", "treatment", "with", "C0044222#ent", "<e2>", ",", "a", "protein", "kinase", "C", "inhibitor"], "h": {"id": "C0123047", "name": "C0123047#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0044222", "name": "C0044222#ent", "pos": [20, 21]}}
{"token": ["Its", "crystal", "structure", "regions", "most", "likely", "involved", "in", "protein-protein", "interactions", "and", "complex", "formation", "is", "required", "for", "C2985257#ent", "<e1>", "to", "activate", "C0812228#ent", "<e2>", "."], "h": {"id": "C2985257", "name": "C2985257#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [20, 21]}}
{"token": ["It", "is", ",", "however", ",", "associated", "with", "persistent", "binding", "of", "the", "silencer", "CCAAT", "displacement", "protein", "C1413827#ent", "<e1>", ")", "to", "the", "C2986618#ent", "<e2>", "promoter", "in", "these", "cells", "."], "h": {"id": "C1413827", "name": "C1413827#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2986618", "name": "C2986618#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "overexpression", "of", "C1413827#ent", "<e1>", "in", "cultured", "myeloid", "stem", "cells", "C2986618#ent", "<e2>", "expression", "upon", "granulocyte", "colony-stimulating", "factor-induced", "neutrophil", "maturation", "blocking", "phenotypic", "maturation", "."], "h": {"id": "C1413827", "name": "C1413827#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986618", "name": "C2986618#ent", "pos": [11, 12]}}
{"token": ["The", "amount", "of", "antidepressants", "used", "ranked", "between", "2", "common", "G-I", "drugs", "C0005632#ent", "<e1>", "(", "Dulcolax", ")", "and", "C0008783#ent", "<e2>", "."], "h": {"id": "C0005632", "name": "C0005632#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [17, 18]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "examine", "the", "effect", "of", "statin", "treatment", "on", "the", "activity", "of", "C0030940#ent", "<e1>", "in", "the", "wall", "of", "abdominal", "aortic", "aneurysms", "C0271742#ent", "<e2>", ")", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0271742", "name": "C0271742#ent", "pos": [26, 27]}}
{"token": ["Therefore", ",", "C1334894#ent", "<e1>", "is", "a", "key", "cofactor", "for", "the", "transforming", "activity", "C0079068#ent", "<e2>", "and", "the", "interaction", "with", "C0079068#ent", "<e2>", "may", "mediate", "the", "enhancement", "of", "proliferation", "and", "transformation", "induced", "by", "C1334894#ent", "<e1>", "overexppression", "."], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [12, 13]}}
{"token": ["C0069156#ent", "<e1>", "NDPase", ")", "activity", ",", "using", "inosine-5'-diphospbate", "(", "C2697821#ent", "<e2>", ")", "as", "a", "substrate", ",", "was", "studied", "by", "light", "and", "electron", "microscope", "cytochemistry", "brain", "and", "spinal", "cord", "normal", "mouse"], "h": {"id": "C0069156", "name": "C0069156#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697821", "name": "C2697821#ent", "pos": [9, 10]}}
{"token": ["Glyceryl", "trinitrate", "nitroglycerin", ")", "and", "C0699440#ent", "<e1>", "may", "be", "advantageous", "in", "patients", "with", "significant", "C1956346#ent", "<e2>"], "h": {"id": "C0699440", "name": "C0699440#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["Brain", "growth-promoting", "activity", "correlated", "with", "C1522567#ent", "<e1>", "serum", ",", "and", "both", "rose", "in", "response", "to", "C1333673#ent", "<e2>", "administration", "."], "h": {"id": "C1522567", "name": "C1522567#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [15, 16]}}
{"token": ["5", "classes", "of", "drugs", "with", "possible", "threatening", "secondary", "effects", "demonstrated", ":", "glykosides", ",", "C3653359#ent", "<e1>", "(", "antidiabetics", ")", ",", "coumarin", "derivatives", "anticoagulants", ")", ",", "C3540726#ent", "<e2>", "and", "parenteral", "contrast", "mediums"], "h": {"id": "C3653359", "name": "C3653359#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3540726", "name": "C3540726#ent", "pos": [24, 25]}}
{"token": ["Consistent", "with", "this", ",", "ammonium", "pyrrolidine", "dithiocarbamate", "a", "pharmacological", "inhibitor", "of", "NF-kappaB", ",", "blocks", "TRAIL-induced", "C1705350#ent", "<e1>", "expression", ",", "and", "C1420556#ent", "<e2>", "overexpression", "increases", "IGF1R", "protein", "."], "h": {"id": "C1705350", "name": "C1705350#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420556", "name": "C1420556#ent", "pos": [20, 21]}}
{"token": ["The", "effect", "of", "cholera", "toxin", "CT", ")", "on", "the", "thyroid-pituitary", "axis", "the", "immune", "system", "examined", "in", "Bio-Breeding/Tokyo", "(", "BB/TKY", ")", "rats", ",", "which", "spontaneously", "develop", "C1852092#ent", "<e1>", "DM", ")", "and", "C0920350#ent", "<e2>", "LT", ")", "."], "h": {"id": "C1852092", "name": "C1852092#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0920350", "name": "C0920350#ent", "pos": [30, 31]}}
{"token": ["The", "C3536889#ent", "<e1>", "misoprostol", "and", "the", "proton", "pump", "inhibitor", "C0028978#ent", "<e2>", "appear", "to", "be", "efficacious", "in", "decreasing", "NSAID-associated", "ulcers", "."], "h": {"id": "C3536889", "name": "C3536889#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [9, 10]}}
{"token": ["P", "<", "0.05", ")", "These", "data", "show", "that", "endothelial", "cells", "be", "transduced", "with", "a", "urokinase", "expressing", "C0079429#ent", "<e1>", "that", "increases", "the", "release", "of", "this", "C0016018#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [24, 25]}}
{"token": ["A", "sural", "nerve", "biopsy", "C1318520#ent", "<e1>", "inflammation", "with", "C0014457#ent", "<e2>", "infiltration", "."], "h": {"id": "C1318520", "name": "C1318520#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [8, 9]}}
{"token": ["Treatment", "with", "C0376515#ent", "<e1>", "antisense", "ODN", "in", "vitro", ">", "80", "%", "reduction", "of", "C4042483#ent", "<e2>", "in", "a", "sequence", "specific", "manner", "for", "both", "cell", "lines"], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4042483", "name": "C4042483#ent", "pos": [13, 14]}}
{"token": ["C0878544#ent", "<e1>", "our", "present", "knowledge-the", "C0018799#ent", "<e2>", "strongly", "interrelated", "with", "cytokines", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [5, 6]}}
{"token": ["The", "dangers", "of", "cobalt", "as", "an", "industrial", "hazard", "pointed", "out", "and", "it", "is", "suggested", "that", "C0878544#ent", "<e1>", "be", "considered", "in", "the", "differential", "diagnosis", "C0018799#ent", "<e2>", "those", "employed", "in", "the", "hard", "metal", "industry", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [23, 24]}}
{"token": ["C0002965#ent", "<e1>", "UA", ")", "is", "characterized", "by", "a", "state", "of", "coronary", "artery", "C0042384#ent", "<e2>", "endothelial", "dysfunction"], "h": {"id": "C0002965", "name": "C0002965#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [12, 13]}}
{"token": ["A", "number", "of", "cytosolic", "proteins", "involved", "in", "its", "activation/deactivation", ":", "p47phox", ",", "p67phox", ",", "C1417610#ent", "<e1>", "and", "the", "small", "GTP-binding", "protein", "C0812228#ent", "<e2>", "."], "h": {"id": "C1417610", "name": "C1417610#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [21, 22]}}
{"token": ["Collagenases", "and", "C0007428#ent", "<e1>", ",", "as", "well", "as", "C0699918#ent", "<e2>", "and", "other", "neutral", "proteinases", "the", "enzymes", "most", "frequently", "associated", "with", "matrix", "destruction", "invasion", "."], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0699918", "name": "C0699918#ent", "pos": [8, 9]}}
{"token": ["Prepubertal", "(", "16", "weeks", "old", ")", "C1419195#ent", "<e1>", "lambs", "were", "used", "to", "investigate", "the", "effects", "of", "C0020550#ent", "<e2>", "and", "hypothyroidism", "on", "development", "of", "reproductive", "endocrine", "function"], "h": {"id": "C1419195", "name": "C1419195#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [16, 17]}}
{"token": ["Disruption", "of", "CD40", "and", "its", "ligand", ",", "C1706005#ent", "<e1>", "leads", "to", "immunodeficiency", "as", "in", "the", "case", "of", "C0272236#ent", "<e2>"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0272236", "name": "C0272236#ent", "pos": [17, 18]}}
{"token": ["To", "test", "this", "hypothesis", ":", "(", "1", ")", "Rats", "were", "injected", "C3273618#ent", "<e1>", "with", "an", "antipyretic", "dose", "of", "C0037549#ent", "<e2>", "300", "mg/kg", ")", "."], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037549", "name": "C0037549#ent", "pos": [18, 19]}}
{"token": ["The", "Gag-Pol", "polyprotein", ",", "in", "addition", "to", "the", "above", "proteins", ",", "C1947941#ent", "<e1>", "(", "PR", ")", ",", "reverse", "transcriptase", "RT", ")", ",", "C1414193#ent", "<e2>", "(", "DU", ")", ",", "and", "integrase", "(", "IN", ")", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414193", "name": "C1414193#ent", "pos": [22, 23]}}
{"token": ["Whereas", "the", "effect", "of", "clonidine", "was", "antagonized", "by", "metiamide", ",", "the", "effect", "of", "C0079466#ent", "<e1>", "was", "not", "antagonized", "by", "any", "blocking", "C0035064#ent", "<e2>", "we", "used", "."], "h": {"id": "C0079466", "name": "C0079466#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [21, 22]}}
{"token": ["In", "parallel", ",", "C2697656#ent", "<e1>", "also", "increases", "the", "amounts", "of", "C1708627#ent", "<e2>"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1708627", "name": "C1708627#ent", "pos": [10, 11]}}
{"token": ["The", "hepatic", "microcirculatory", "dysfunction", "by", "C2697656#ent", "<e1>", "was", "minimized", "in", "mice", "pretreated", "with", "AA-861", "or", "in", "C1708627#ent", "<e2>", "knockout", "mice"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1708627", "name": "C1708627#ent", "pos": [16, 17]}}
{"token": ["C0020676#ent", "<e1>", "diagnosed", "in", "a", "woman", "aged", "33", "years", ",", "with", "C0013080#ent", "<e2>", "insulin-dependent", "diabetes", "mellitus", "admission", "to", "hospital", "with", "hypoglycaemia", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0013080", "name": "C0013080#ent", "pos": [11, 12]}}
{"token": ["A", "major", "contrast", "with", "the", "aspirin-like", "drugs", "is", "that", "C0282070#ent", "<e1>", "is", "a", "weak", "inhibitor", "of", "the", "synthesis", "of", "C0356622#ent", "<e2>", "but", "it", "has", "several", "properties", "which", "may", "contribute", "to", "its", "anti-inflammatory", "activity"], "h": {"id": "C0282070", "name": "C0282070#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [19, 20]}}
{"token": ["Horseradish", "peroxidase", "C3889156#ent", "<e1>", ")", "is", "known", "to", "degrade", "certain", "recalcitrant", "organic", "compounds", "as", "C0031428#ent", "<e2>", "and", "substituted", "phenols", "."], "h": {"id": "C3889156", "name": "C3889156#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [14, 15]}}
{"token": ["Agenesis", "of", "the", "C0431399#ent", "<e1>", "paleocerebellar", "agenesis", "with", "fusion", "of", "the", "cerebellar", "hemispheres", "C1866130#ent", "<e2>", ")", "is", "a", "rare", "malformation", "of", "the", "central", "nervous", "system", "CNS", ")", "."], "h": {"id": "C0431399", "name": "C0431399#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1866130", "name": "C1866130#ent", "pos": [13, 14]}}
{"token": ["Placental", "leucine", "aminopeptidase", "P-LAP", ")", "which", "is", "identical", "with", "C0030098#ent", "<e1>", "oxytocinase", "was", "found", "to", "be", "a", "C1334043#ent", "<e2>", "of", "rat", "insulin-regulated", "membrane", "aminopeptidase", "IRAP", ")", "by", "cDNA", "cloning"], "h": {"id": "C0030098", "name": "C0030098#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}}
{"token": ["Placental", "leucine", "aminopeptidase", "P-LAP", ")", ",", "which", "is", "identical", "with", "C0030098#ent", "<e1>", "oxytocinase", ",", "was", "found", "to", "be", "C1334043#ent", "<e2>", "with", "rat", "insulin-regulated", "membrane", "aminopeptidase", "IRAP", ")", "by", "sequence", "comparison", "."], "h": {"id": "C0030098", "name": "C0030098#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["Membrane", "proteins", "human", "erythrocytes", "can", "be", "phosphorylated", "not", "only", "by", "C0108554#ent", "<e1>", "MS", ")", "but", "also", "by", "cytosolic", "casein", "kinases", "CS", "C0007286#ent", "<e2>", ",", "resembling", "casein", "kinase", "I", "II", ",", "respectively", "."], "h": {"id": "C0108554", "name": "C0108554#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [21, 22]}}
{"token": ["Only", "four", "cardiac", "deaths", "after", "a", "follow-up", "of", "8.8", "+", "/-", "7.2", "years", ":", "three", "by", "C0264714#ent", "<e1>", "and", "only", "one", "by", "recurrent", "C0042510#ent", "<e2>", "."], "h": {"id": "C0264714", "name": "C0264714#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "the", "positive", "interactions", "between", "bisphosphonates", "and", "farnesyltransferase", "inhibitors", "KIT", "receptor", "tyrosine", "kinase", "inhibitors", "e.g.", "C0939537#ent", "<e1>", "mesylate", ")", "and", "C0085387#ent", "<e2>", "discussed", "in", "relation", "to", "their", "potential", "synergistic", "and", "additive", "effects"], "h": {"id": "C0939537", "name": "C0939537#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [21, 22]}}
{"token": ["Neuropsychological", "tests", "for", "the", "assessment", "of", "C0019151#ent", "<e1>", "C1822717#ent", "<e2>", ")", "may", "overdiagnose", "C1822717#ent", "<e2>", "because", "scores", "are", "usually", "not", "corrected", "for", "age", "."], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1822717", "name": "C1822717#ent", "pos": [8, 9]}}
{"token": ["Six", "quantitative", "psychometric", "tests", "performed", "on", "51", "healthy", "subjects", "19", "cirrhotic", "patients", "with", "C0019151#ent", "<e1>", "C1822717#ent", "<e2>", ")", ",", "32", "cirrhotic", "patients", "without", "C1822717#ent", "<e2>", ",", "and", "26", "patients", "with", "other", "diseases", "."], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1822717", "name": "C1822717#ent", "pos": [15, 16]}}
{"token": ["We", "cloned", "the", "C0752125#ent", "<e1>", "C0017337#ent", "<e2>", "from", "a", "yeast", "artificial", "chromosome", "YAC", ")", "clone", "contig", "spanning", "the", "C0752125#ent", "<e1>", "candidate", "region", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0752125", "name": "C0752125#ent", "pos": [3, 4]}}
{"token": ["The", "C0017337#ent", "<e1>", "for", "ADCA", "type", "II", "was", "mapped", "to", "the", "spinocerebellar", "ataxia", "7", "C0752125#ent", "<e2>", ")", "locus", "on", "chromosome", "3p12-p21.1", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0752125", "name": "C0752125#ent", "pos": [14, 15]}}
{"token": ["The", "C0017337#ent", "<e1>", "for", "ADCA", "type", "II", "was", "mapped", "to", "the", "C0752125#ent", "<e2>", "SCA7", ")", "locus", "on", "chromosome", "3p12-p21.1", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0752125", "name": "C0752125#ent", "pos": [11, 12]}}
{"token": ["Arsenazo", "III", "used", "to", "investigate", "Ca2", "+", "transients", "in", "the", "normally", "non-excitable", "C0702216#ent", "<e1>", "of", "the", "C0017547#ent", "<e2>", "neurones", "of", "the", "crayfish", "Procambarus", "clarkii", "."], "h": {"id": "C0702216", "name": "C0702216#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [16, 17]}}
{"token": ["Their", "large", "terminals", "form", "synapses", "on", "the", "C0702216#ent", "<e1>", "and", "the", "proximal", "dendrites", "of", "the", "C0017547#ent", "<e2>", "and", "large", "neurons", "."], "h": {"id": "C0702216", "name": "C0702216#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "the", "augmenting", "effect", "of", "mouse", "recombinant", "interferon-beta", "MurIFN-beta", ")", "on", "the", "induction", "of", "macrophage", "(", "C1333690#ent", "<e1>", "cytolytic", "activity", "by", "C1522405#ent", "<e2>", "(", "IL-2", ")", "."], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [22, 23]}}
{"token": ["The", "nucleotide", "exchange", "factor", "C1539265#ent", "<e1>", "influenced", "ATPase", "of", "wild", "type", "C1540056#ent", "<e2>", "and", "each", "mutant", "differently", "."], "h": {"id": "C1539265", "name": "C1539265#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1540056", "name": "C1540056#ent", "pos": [11, 12]}}
{"token": ["All", "five", "C1332416#ent", "<e1>", "operated", "dogs", "had", "severe", "tricuspid", "regurgitation", "C0235527#ent", "<e2>", "including", "massive", "ascites", ",", "but", "they", "did", "not", "have", "left", "heart", "failure"], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0235527", "name": "C0235527#ent", "pos": [10, 11]}}
{"token": ["Phedase", "and", "C1418706#ent", "<e1>", "consisted", "of", "both", "senescence-induced", "and", "constitutive", "C3541394#ent", "<e2>", "."], "h": {"id": "C1418706", "name": "C1418706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "beta", "directly", "binds", "the", "C1418729#ent", "<e1>", "contact", "with", "alpha", ",", "the", "C3811771#ent", "<e2>"], "h": {"id": "C1418729", "name": "C1418729#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3811771", "name": "C3811771#ent", "pos": [13, 14]}}
{"token": ["Serum", "levels", "of", "human", "hepatocyte", "growth", "factor", "C1420314#ent", "<e1>", ")", "were", "determined", "in", "38", "patients", "with", "C0001339#ent", "<e2>", "an", "enzyme-linked", "immunosorbent", "assay"], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [16, 17]}}
{"token": ["Administration", "of", "C1420314#ent", "<e1>", "without", "induction", "of", "C0001339#ent", "<e2>", "increased", "pancreatic", "prostaglandin", "E(2)", "and", "plasma", "interleukin-10", ",", "and", "this", "effect", "was", "abolished", "by", "the", "cyclooxygenase-2", "inhibitor", "rofecoxib", "."], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [7, 8]}}
{"token": ["Mepyramine", ",", "methysergide", ",", "cimetidine", ",", "C0012694#ent", "<e1>", "phenylbutazone", ",", "and", "C0050537#ent", "<e2>", "reduced", "to", "varying", "degrees", "after", "cutaneous", "application", "the", "primary", "irritation", "the", "delayed", "hypersensitivity", "inflammation", "induced", "by", "picryl", "chloride"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0050537", "name": "C0050537#ent", "pos": [11, 12]}}
{"token": ["PGE", "1", "-", "2", "and", "C0012694#ent", "<e1>", "prevented", "the", "bronchospasm", "induced", "by", "inhalation", "or", "ingestion", "of", "C0050537#ent", "<e2>", "a", "small", "group", "patients", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0050537", "name": "C0050537#ent", "pos": [16, 17]}}
{"token": ["None", "of", "CFTR's", "native", "C2717970#ent", "<e1>", "was", "found", "essential", "for", "wild", "type-like", ",", "phosphorylation-", "and", "C0101555#ent", "<e2>", ",", "channel", "gating"], "h": {"id": "C2717970", "name": "C2717970#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [15, 16]}}
{"token": ["We", "evaluated", "the", "pharmacokinetics", ",", "efficacy", "and", "safety", "of", "C0286738#ent", "<e1>", "1,000/100", "mg", "twice", "daily", "plus", "C0282519#ent", "<e2>", "13", "women", "during", "late", "pregnancy", "compared", "the", "results", "to", "those", "of", "15", "non-pregnant", "women", "."], "h": {"id": "C0286738", "name": "C0286738#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0282519", "name": "C0282519#ent", "pos": [16, 17]}}
{"token": ["Responder", "rates", "than", "75", "%", "had", "to", "be", "accepted", "for", "C0005026#ent", "<e1>", "sodium", "hydroxide", "order", "to", "prevent", "overly", "severe", "reactions", ",", "whilst", "C0072225#ent", "<e2>", "to", "have", "only", "marginal", "irritant", "properties", "."], "h": {"id": "C0005026", "name": "C0005026#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0072225", "name": "C0072225#ent", "pos": [22, 23]}}
{"token": ["Healthy", ",", "human", "volunteers", "were", "patch", "tested", "for", "48", "h", "with", "the", "following", "six", "chemically", "unrelated", "irritants", "and", "their", "appropriate", "vehicle", "controls", "C0005026#ent", "<e1>", "sodium", "lauryl", "sulphate", "dithranol", ",", "nonanoic", "acid", "croton", "oil", "and", "C0072225#ent", "<e2>"], "h": {"id": "C0005026", "name": "C0005026#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0072225", "name": "C0072225#ent", "pos": [34, 35]}}
{"token": ["To", "determine", "whether", "increases", "in", "mRNA", "levels", "of", "MnSOD", "were", "translated", "into", "protein", ",", "Western", "blot", "analyses", "performed", "on", "C0220742#ent", "<e1>", "and", "HAL", "cells", "exposed", "to", "asbestos", "or", "C0393003#ent", "<e2>", "."], "h": {"id": "C0220742", "name": "C0220742#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0393003", "name": "C0393003#ent", "pos": [28, 29]}}
{"token": ["In", "another", "87", "cases", "of", "SLE", "without", "any", "history", "of", "C0036572#ent", "<e1>", ",", "as", "well", "as", "61", "cases", "of", "other", "autoimmune", "diseases", "C0038013#ent", "<e2>", "progressive", "systemic", "sclerosis", "mixed", "connective", "tissue", "disease", "etc", ".", ")"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [22, 23]}}
{"token": ["Neurturin", "(", "C1705507#ent", "<e1>", ")", ",", "a", "potent", "C1522444#ent", "<e2>", "specifically", "on", "dopaminergic", "neurons", "is", "comprised", "of", "102", "amino", "acids", "a", "mature", "protein", "."], "h": {"id": "C1705507", "name": "C1705507#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522444", "name": "C1522444#ent", "pos": [8, 9]}}
{"token": ["Under", "such", "conditions", "the", "anti-SRBC", "plaque-forming", "cell", "(", "PFC", ")", "response", "was", "amplified", "equally", "(", "approximately", "10-fold", ")", "by", "SRBC-fed", "C1413347#ent", "<e1>", "in", "normal", "controls", "patients", "with", "C0677607#ent", "<e2>", "euthyroid", "with", "thyroxine", "replacement"], "h": {"id": "C1413347", "name": "C1413347#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [27, 28]}}
{"token": ["The", "antagonistic", "activity", "ibuprofen", "appears", "unrelated", "to", "its", "C0003211#ent", "<e1>", "drug", "activity", "other", "C0003211#ent", "<e1>", "drugs", "such", "as", "C0021246#ent", "<e1>", "and", "tolmetin", "have", "minimal", "antagonistic", "activity"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [8, 9]}, "relation": "structural_class_of", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [18, 19]}}
{"token": ["A", "standard", "regimen", "C0063252#ent", "<e1>", "was", "more", "cost-effective", "than", "C1420652#ent", "<e2>", "propofol", "for", "anesthesia", "maintenance", "in", "achieving", "PONV-free", "episodes", "."], "h": {"id": "C0063252", "name": "C0063252#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420652", "name": "C1420652#ent", "pos": [9, 10]}}
{"token": ["Mutations", "in", "C1417679#ent", "<e1>", "coding", "for", "components", "of", "the", "SCF", "pathway", "such", "as", "C1332809#ent", "<e2>", ",", "UbcD2", "and", "effete", "enhance", "the", "extra", "division", "phenotype", "of", "encore", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332809", "name": "C1332809#ent", "pos": [13, 14]}}
{"token": ["We", "report", "four", "patients", "who", "had", "C0017601#ent", "<e1>", "in", "association", "with", "the", "C0026709#ent", "<e2>"], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0026709", "name": "C0026709#ent", "pos": [12, 13]}}
{"token": ["Most", "cases", "of", "chronic", "desquamative", "gingivitis", "C2677590#ent", "<e1>", ")", "are", "shown", "by", "direct", "immunofluorescence", "C1710304#ent", "<e2>", ")", "to", "be", "immune", "mediated", "diseases"], "h": {"id": "C2677590", "name": "C2677590#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", ",", "remarkably", ",", "C0025677#ent", "<e1>", "enhances", "incorporation", "and", "cytotoxicity", "of", "ara-C", "through", "regulation", "of", "C1333205#ent", "<e2>", "activity", "in", "Burkitt's", "lymphoma", "cells"], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333205", "name": "C1333205#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "the", "vomeronasal", "system", "respond", "highly", "selectively", "to", "non-volatile", "peptide", "ligands", "associated", "with", "C0024518#ent", "<e1>", ",", "acting", "at", "the", "V2r", "class", "of", "C1422056#ent", "<e2>"], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1422056", "name": "C1422056#ent", "pos": [24, 25]}}
{"token": ["Other", "important", "differences", "between", "strains", "and", "structures", "occurred", "in", "the", "C0036572#ent", "<e1>", "profiles", ",", "including", "latency", "to", "forelimb", "clonus", "C0009024#ent", "<e2>", "duration", "of", "associated", "local", "afterdischarges", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0009024", "name": "C0009024#ent", "pos": [19, 20]}}
{"token": ["Low-frequency", "(", "6", "Hz", ")", ",", "long-duration", "(", "3", "s", ")", "electrical", "stimulation", "in", "mice", "produces", "C0036572#ent", "<e1>", "characterized", "by", "immobility", ",", "C0009024#ent", "<e2>", "and", "automatic", "behaviors", "of", "human", "limbic", "epilepsy"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0009024", "name": "C0009024#ent", "pos": [22, 23]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "examine", "the", "C0271710#ent", "<e1>", "the", "aqueous", "extract", "of", "the", "aerial", "part", "of", "Suaeda", "fruticosa", "C0876942#ent", "<e2>", ")", "in", "normal", "and", "streptozotocin-induced", "diabetic", "rats", "."], "h": {"id": "C0271710", "name": "C0271710#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0876942", "name": "C0876942#ent", "pos": [21, 22]}}
{"token": ["The", "biological", "response", "C0084370#ent", "<e1>", "is", "mediated", "by", "binding", "of", "its", "ligand", ",", "C0669372#ent", "<e2>", "growth", "factor-like", "protein/macrophage", "stimulating-protein", "(", "HGFL", ")", "."], "h": {"id": "C0084370", "name": "C0084370#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "inhibition", "of", "RREB-1", "expression", "by", "RNA", "interference", "enhanced", "the", "effect", "of", "C0525678#ent", "<e1>", "on", "C3810537#ent", "<e2>", "promoter", "activity", "C3810537#ent", "<e2>", "expression", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3810537", "name": "C3810537#ent", "pos": [16, 17]}}
{"token": ["Thirteen", "of", "the", "31", "patients", "(", "42", "%", ")", "manifested", "some", "degree", "of", "C0019151#ent", "<e1>", "as", "interpreted", "by", "necessity", "for", "protein", "restriction", "either", "Neomycin", "or", "C0022957#ent", "<e2>", "."], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0022957", "name": "C0022957#ent", "pos": [25, 26]}}
{"token": ["They", "exhibited", "comparable", "catalytic", "activities", "C0005080#ent", "<e1>", ",", "7-ethoxycoumarin", ",", "and", "7-ethoxyresorufin", ",", "when", "reconstituted", "with", "C0027310#ent", "<e2>", "phosphatidylserine", "."], "h": {"id": "C0005080", "name": "C0005080#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027310", "name": "C0027310#ent", "pos": [16, 17]}}
{"token": ["To", "examine", "the", "role", "of", "C1420173#ent", "<e1>", ",", "clones", "which", "stably", "overexpress", "C1420173#ent", "<e1>", "were", "developed", "from", "both", "C1415380#ent", "<e1>", "and", "CGL4", "cells", "."], "h": {"id": "C1420173", "name": "C1420173#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415380", "name": "C1415380#ent", "pos": [18, 19]}}
{"token": ["Dietary", "change", "retarded", "overall", "progression", "and", "increased", "overall", "regression", "of", "C1956346#ent", "<e1>", "and", "diet", "plus", "C0008402#ent", "<e2>", "was", "additionally", "associated", "with", "net", "increase", "in", "coronary", "lumen", "diameter"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [10, 11]}, "relation": "may_be_prevented_by", "t": {"id": "C0008402", "name": "C0008402#ent", "pos": [15, 16]}}
{"token": ["The", "pleiotropic", "effects", "of", "retinoic", "acid", "RA", ")", "in", "mammalian", "cells", "mediated", "by", "two", "classes", "of", "proteins", ":", "the", "C1335591#ent", "<e1>", "RAR", ")", "and", "C3538961#ent", "<e2>", "CRABP-I", "and", "CRABP-II", ")", "."], "h": {"id": "C1335591", "name": "C1335591#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3538961", "name": "C3538961#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "the", "alteration", "of", "C1456392#ent", "<e1>", "RXRalpha", ")", "mRNA", "level", "in", "normal", "human", "keratinocytes", "after", "C0050559#ent", "<e2>", "and/or", "NB-UVB", "irradiation", "treatment", "."], "h": {"id": "C1456392", "name": "C1456392#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0050559", "name": "C0050559#ent", "pos": [16, 17]}}
{"token": ["In", "cancer", "therapy", "there", "have", "been", "case", "reports", "hormonal", "drugs", "as", "estrogen", "receptor", "antagonists", "aromatase", "inhibitors", "and", "C1414313#ent", "<e1>", "EGFR", ")", "inhibitors", "can", "induce", "C0262988#ent", "<e2>"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0262988", "name": "C0262988#ent", "pos": [24, 25]}}
{"token": ["High", "concentrations", "of", "C0021246#ent", "<e1>", ",", "meclofenamate", "and", "aspirin", "inhibited", "activation", "of", "C1417810#ent", "<e2>", "arachidonic", "acid", "phospholipase", "A2", "without", "altering", "basal", "enzyme", "activity", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417810", "name": "C1417810#ent", "pos": [12, 13]}}
{"token": ["In", "recent", "years", ",", "however", ",", "doubt", "has", "increased", "as", "to", "whether", "C0017574#ent", "<e1>", "and", "even", "the", "C0031030#ent", "<e2>", "can", "be", "considered", "as", "comprising", "a", "single", "disease"], "h": {"id": "C0017574", "name": "C0017574#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031030", "name": "C0031030#ent", "pos": [17, 18]}}
{"token": ["Immediate", "sequelae", "of", "long-chain-base", "starvation", "were", "loss", "of", "viability", "exacerbated", "in", "the", "presence", "of", "C0051348#ent", "<e1>", ",", "and", "loss", "of", "C0312059#ent", "<e2>", "sphingolipid", "synthesis", "but", "not", "phosphatidylinositol", "synthesis"], "h": {"id": "C0051348", "name": "C0051348#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0312059", "name": "C0312059#ent", "pos": [20, 21]}}
{"token": ["The", "denaturation", "temperatures", "C0009325#ent", "<e1>", "film", "and", "pieces", "of", "C0035372#ent", "<e2>", "were", "different", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035372", "name": "C0035372#ent", "pos": [9, 10]}}
{"token": ["On", "the", "other", "hand", ",", "BRCA1", "failed", "to", "alter", "the", "expression", "of", "the", "C1530423#ent", "<e1>", "CBP", ")", ",", "the", "structural", "and", "functional", "homologue", "of", "C1333336#ent", "<e2>", ",", "in", "any", "of", "these", "cell", "types"], "h": {"id": "C1530423", "name": "C1530423#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333336", "name": "C1333336#ent", "pos": [24, 25]}}
{"token": ["The", "objective", "of", "this", "analysis", "was", "to", "describe", "the", "pharmacokinetic", "characteristics", "of", "C1142738#ent", "<e1>", "in", "patients", "with", "serious", "C0026946#ent", "<e2>", "on", "pharmacokinetic", "data", "collected", "during", "four", "recently", "completed", "or", "ongoing", "Phase", "II/III", "clinical", "studies"], "h": {"id": "C1142738", "name": "C1142738#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [18, 19]}}
{"token": ["The", "effect", "of", "C0543459#ent", "<e1>", ",", "a", "new", "C0003195#ent", "<e2>", "on", "ventricular", "refractoriness", "and", "monophasic", "action", "potentials", "from", "the", "right", "ventricle", "studied", "in", "nine", "subjects", "."], "h": {"id": "C0543459", "name": "C0543459#ent", "pos": [3, 4]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["The", "presentation", "during", "immune", "reconstitution", "that", "C1290398#ent", "<e1>", "pediatric", "patients", "with", "acquired", "C0001175#ent", "<e2>", "result", "from", "an", "immune-mediated", "response", "chronic", "vascular", "infection"], "h": {"id": "C1290398", "name": "C1290398#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [12, 13]}}
{"token": ["This", "mechanism", "of", "action", "may", "also", "be", "prevalent", "in", "the", "C0038317#ent", "<e1>", "effect", "on", "corneal", "reepithelialization", "and", "experiments", "are", "under", "way", "to", "C1875400#ent", "<e2>", "this", "inhibitory", "protein", "steroid-treated", "conjunctival", "epithelium"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [22, 23]}}
{"token": ["Clinically", "most", "C1853247#ent", "<e1>", "patients", "present", "with", "a", "pure", "C0037772#ent", "<e2>", "rare", "complicating", "features", "were", "restricted", "to", "symptoms", "or", "signs", "of", "peripheral", "nerve", "involvement", "."], "h": {"id": "C1853247", "name": "C1853247#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037772", "name": "C0037772#ent", "pos": [9, 10]}}
{"token": ["Analysis", "of", "rice", ",", "maize", "and", "Arabidopsis", "C3539530#ent", "<e1>", "cDNA", "species", "revealed", "that", "the", "monocot", "C0014442#ent", "<e2>", "possesses", "an", "extended", "C-terminus", "relative", "to", "dicot", "and", "human", "enzymes", "."], "h": {"id": "C3539530", "name": "C3539530#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["Noise", "stress", "induced", "divergent", "corticosterone", "responses", "in", "C0064906#ent", "<e1>", "and", "FSL", ",", "but", "did", "not", "affect", "VMR", "to", "C0035334#ent", "<e2>", "in", "either", "group", "."], "h": {"id": "C0064906", "name": "C0064906#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [18, 19]}}
{"token": ["Of", "215", "C0242350#ent", "<e1>", "patients", "subsequently", "treated", "with", "C0724441#ent", "<e2>", ",", "38", "%", "reported", "some", "subjective", "improvement", "but", "only", "5", "%", "were", "completely", "satisfied", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [8, 9]}}
{"token": ["The", "bacterial", "gene", "ubiC", "encodes", "chorismate", "pyruvate-lyase", "an", "C0014442#ent", "<e1>", "which", "converts", "chorismate", "to", "C0000500#ent", "<e2>", "and", "which", "is", "not", "normally", "present", "in", "plants", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000500", "name": "C0000500#ent", "pos": [14, 15]}}
{"token": ["While", "TFRGAP", "was", "without", "effect", "on", "C1705791#ent", "<e1>", "activation", "in", "C4085213#ent", "<e2>", "+", "KOLF", "cells", ",", "it", "induced", "MAPK", "activation", "in", "KOLF", "cells", "transfected", "with", "PAR1", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4085213", "name": "C4085213#ent", "pos": [10, 11]}}
{"token": ["Transcription", "factor", "NF-kappa", "B", "two", "proteins", ",", "C3273276#ent", "<e1>", "and", "p65", ",", "that", "have", "sequence", "similarity", "the", "C0035018#ent", "<e2>", "oncogene", "."], "h": {"id": "C3273276", "name": "C3273276#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035018", "name": "C0035018#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "both", "p105", "and", "C3273276#ent", "<e1>", "can", "complex", "directly", "with", "C0035018#ent", "<e2>", "and", "chicken", "c-Rel", "in", "vitro"], "h": {"id": "C3273276", "name": "C3273276#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035018", "name": "C0035018#ent", "pos": [11, 12]}}
{"token": ["Soil", "C1412791#ent", "<e1>", "movement", "from", "erosional", "slopes", "alluvial", "fans", "C2712370#ent", "<e2>", "the", "mosaic", "of", "C1412791#ent", "<e1>", "metabolism", "and", "storage", "across", "the", "landscape", "."], "h": {"id": "C1412791", "name": "C1412791#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [9, 10]}}
{"token": ["C0040558#ent", "<e1>", "(", "two", "patients", ")", ",", "C0000833#ent", "<e2>", "two", "cases", ")", ",", "viral", "encephalitis", "two", "patients", ")", "and", "only", "gliosis", "(", "two", "cases", ")", "accounted", "for", "almost", "half", "of", "the", "cases", "."], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [7, 8]}}
{"token": ["Consequently", ",", "C1336694#ent", "<e1>", "enzyme", "activity", "hydrolysis", "of", "major", "C1861451#ent", "<e2>", "were", "enhanced", "."], "h": {"id": "C1336694", "name": "C1336694#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1861451", "name": "C1861451#ent", "pos": [9, 10]}}
{"token": ["Addition", "of", "cyanamide", ",", "an", "C3850110#ent", "<e1>", "to", "the", "AIN'76", "C0001962#ent", "<e2>", "increased", "the", "intensity", "of", "the", "37-kD", "protein-acetaldehyde", "adduct", "band", "on", "electroimmunotransblot", "but", "did", "not", "produce", "other", "bands", "."], "h": {"id": "C3850110", "name": "C3850110#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [10, 11]}}
{"token": ["C3539661#ent", "<e1>", "preparations", "need", "to", "be", "checked", "for", "presence", "of", "C0030946#ent", "<e2>", "contaminants", "."], "h": {"id": "C3539661", "name": "C3539661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [10, 11]}}
{"token": ["On", "correction", "of", "C3665349#ent", "<e1>", "with", "oral", "thyroxine", "her", "C3641106#ent", "<e2>", "to", "normal", "and", "menorrhagia", "ceased", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3641106", "name": "C3641106#ent", "pos": [9, 10]}}
{"token": ["Ablation", "of", "sensory", "neurons", "(", "by", "capsaicin", ")", "markedly", "decreased", "the", "PAR2-mediated", "airway", "constriction", "and", "virtually", "abolished", "PAR2-mediated", "C3714636#ent", "<e1>", "edema", ",", "as", "did", "blockade", "of", "C1424685#ent", "<e2>", "or", "NK2", "receptors"], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1424685", "name": "C1424685#ent", "pos": [26, 27]}}
{"token": ["The", "presence", "or", "absence", "of", "C1420806#ent", "<e1>", "was", "defined", "by", "a", "nested", "PCR", "approach", "C1705969#ent", "<e2>", "microsatellite", "polymorphisms", "were", "detected", "with", "fluorescence-labeled", "primer", "on", "an", "automated", "sequencing", "system", "."], "h": {"id": "C1420806", "name": "C1420806#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [14, 15]}}
{"token": ["A", "new", "method", "to", "assay", "des-gamma-carboxyprothrombin", "C2984140#ent", "<e1>", ")", "activity", "is", "described", ",", "using", "staphylocoagulase", "on", "undiluted", "C0376259#ent", "<e2>", "plasma", "after", "adsorption", "with", "bentonite", "(", "to", "remove", "fibrinogen", ")", ",", "then", "with", "aluminium", "hydroxide"], "h": {"id": "C2984140", "name": "C2984140#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0376259", "name": "C0376259#ent", "pos": [17, 18]}}
{"token": ["The", "role", "of", "ischemia", "and", "C0442874#ent", "<e1>", "have", "not", "been", "evaluated", ",", "but", "C0036690#ent", "<e2>", "was", "highly", "determinant", "factor", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [13, 14]}}
{"token": ["C0035369#ent", "<e1>", "vector-mediated", "overexpression", "of", "C0086661#ent", "<e2>", "in", "embryonic", "bursal", "precursors", "induces", "multi-staged", "tumorigenesis", "beginning", "with", "preneoplastic-transformed", "follicles", "(", "TF", ")", "and", "progressing", "to", "clonal", "metastatic", "B-cell", "lymphomas"], "h": {"id": "C0035369", "name": "C0035369#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [5, 6]}}
{"token": ["These", "data", "indicate", "that", "IT", "morphine", "induces", "C0030481#ent", "<e1>", "a", "concomitant", "increase", "in", "CSF", "C0017789#ent", "<e2>", ",", "which", "is", "involved", "in", "NMDA", "receptor", "activation", "."], "h": {"id": "C0030481", "name": "C0030481#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [14, 15]}}
{"token": ["These", "data", "demonstrate", "that", "C0012177#ent", "<e1>", "modulates", "circulating", "C0039902#ent", "<e2>", "and", "cholesterol", "levels", "hypercholesterolemic", "individuals", "by", "distinct", "mechanisms", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [8, 9]}}
{"token": ["C0290427#ent", "<e1>", "is", "a", "C3828359#ent", "<e2>", "is", "expressed", "widely", "in", "the", "developing", "nervous", "system", "that", "controls", "the", "growth", "and", "retinotopic", "mapping", "of", "retinal", "axons", "."], "h": {"id": "C0290427", "name": "C0290427#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3828359", "name": "C3828359#ent", "pos": [4, 5]}}
{"token": ["Northern", "analyses", "revealed", "GPR78", "mRNA", "expression", "in", "the", "C0032002#ent", "<e1>", "and", "placenta", "and", "C1415263#ent", "<e2>", "expression", "in", "the", "C0032002#ent", "<e1>", "."], "h": {"id": "C1415263", "name": "C1415263#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [8, 9]}}
{"token": ["The", "importance", "of", "this", "C0014442#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0038463#ent", "<e2>", "is", "underscored", "by", "the", "observation", "that", "invasion", "by", "larvae", "of", "skin", "in", "vitro", "prevented", "by", "metalloprotease", "inhibitors"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038463", "name": "C0038463#ent", "pos": [10, 11]}}
{"token": ["Leupeptin", ",", "a", "C0033607#ent", "<e1>", "did", "not", "affect", "insulin", "or", "C1334089#ent", "<e2>", "binding", "in", "either", "cell", "type"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [10, 11]}}
{"token": ["C0015300#ent", "<e1>", "has", "been", "induced", "in", "carp", "by", "injecting", "thyrotropin", "releasing", "hormone", "C1705225#ent", "<e2>", ")", "(", "PYRO-glutamyl-histidyl-prolinamide", ")", "into", "the", "coelom", "."], "h": {"id": "C0015300", "name": "C0015300#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [12, 13]}}
{"token": ["Dioxabicyclooctanyl", "C0027375#ent", "<e1>", "have", "been", "reported", "as", "a", "class", "of", "potent", "and", "C1412361#ent", "<e2>", "5-LO", ")", "inhibitors", "."], "h": {"id": "C0027375", "name": "C0027375#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412361", "name": "C1412361#ent", "pos": [12, 13]}}
{"token": ["This", "method", ",", "termed", "the", "compaction", "assay", ",", "was", "used", "to", "assess", "the", "response", "of", "C0010674#ent", "<e1>", "CF", ")", "sputum", "samples", "the", "addition", "of", "recombinant", "human", "deoxyribonuclease", "I", "C1135662#ent", "<e2>", ")", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C1135662", "name": "C1135662#ent", "pos": [28, 29]}}
{"token": ["Because", "several", "viruses", "induce", "IFN-alpha", "production", ",", "severe", "courses", "of", "C0019372#ent", "<e1>", "nonimmunocompromised", "patients", "may", "be", "related", "to", "numerical", "or", "functional", "C0309720#ent", "<e2>", "deficits", "."], "h": {"id": "C0019372", "name": "C0019372#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0309720", "name": "C0309720#ent", "pos": [21, 22]}}
{"token": ["A", "72-year-old", "male", "patient", "with", "dilated", "cardiomyopathy", "treated", "with", "C0086303#ent", "<e1>", "100", "mg/day", ")", "for", "persistent", "atrial", "fibrillation", "C0004238#ent", "<e2>", ")", "that", "could", "not", "be", "converted", "to", "sinus", "rhythm", "by", "electrical", "cardioversion"], "h": {"id": "C0086303", "name": "C0086303#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [18, 19]}}
{"token": ["During", "the", "fifth", "month", ",", "the", "patient", "was", "put", "on", "C0086303#ent", "<e1>", "in", "an", "attempt", "to", "minimize", "the", "C0004238#ent", "<e2>", "recurrence", "rate", "."], "h": {"id": "C0086303", "name": "C0086303#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [18, 19]}}
{"token": ["On", "the", "contrary", ",", "deletion", "of", "the", "betagamma", "subunit", "binding", "region", "in", "the", "C-terminal", "domain", "C1705403#ent", "<e1>", "did", "not", "significantly", "alter", "the", "ability", "of", "the", "C0027203#ent", "<e2>", "to", "phosphorylate", "rhodopsin", "."], "h": {"id": "C1705403", "name": "C1705403#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [25, 26]}}
{"token": ["Nucleotide", "excision", "repair", "inhibitors", "as", "aphidicolin", ",", "1-beta-D-arabinofuranosyl", "cytosine", "(", "C0060103#ent", "<e1>", ")", "and", "hydroxyurea", ",", "but", "not", "the", "base", "excision", "repair", "C0002569#ent", "<e2>", "caused", "a", "strong", "increase", "in", "DNA", "strand", "breaks"], "h": {"id": "C0060103", "name": "C0060103#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002569", "name": "C0002569#ent", "pos": [22, 23]}}
{"token": ["C0011816#ent", "<e1>", "had", "a", "more", "marked", "effect", "on", "C0968461#ent", "<e2>", "expression", "in", "C2C12", "cells", ",", "but", "did", "not", "affect", "C0968461#ent", "<e2>", "expression", "in", "either", "muscle", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0968461", "name": "C0968461#ent", "pos": [8, 9]}}
{"token": ["Anterior", "ischemic", "optic", "neuropathy", "C1825590#ent", "<e1>", ")", "is", "a", "rare", "complication", "in", "patients", "on", "C1424987#ent", "<e2>", "."], "h": {"id": "C1825590", "name": "C1825590#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424987", "name": "C1424987#ent", "pos": [14, 15]}}
{"token": ["C0025007#ent", "<e1>", "is", "a", "highly", "infectious", ",", "C0042769#ent", "<e2>", "can", "cause", "severe", "pneumonia", ",", "diarrhea", ",", "encephalitis", ",", "and", "death", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["The", "technique", "described", "has", "potential", "for", "rapid", "laboratory", "diagnosis", "C0025007#ent", "<e1>", "and", ",", "possibly", ",", "of", "other", "C0042769#ent", "<e2>", "the", "acute", "stage", "before", "measurable", "amounts", "of", "antibodies", "are", "produced", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [17, 18]}}
{"token": ["C0025007#ent", "<e1>", "is", "a", "highly", "C0042769#ent", "<e2>"], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}}
{"token": ["Insulin-dependent", "diabetes", "mellitus", "mainly", "associated", "to", "immunological", "problems", "probably", "by", "derangement", "caused", "by", "external", "factors", ",", "such", "as", "C0162628#ent", "<e1>", "favor", "destruction", "of", "beta", "cells", "the", "C0771711#ent", "<e2>", "."], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [26, 27]}}
{"token": ["Alzheimer's", "disease", "AD", ")", "is", "characterized", "by", "C0221406#ent", "<e1>", "of", "A", "beta", "derived", "from", "C1364818#ent", "<e2>", "cleavage", "via", "beta-", "and", "gamma-secretase", "pathway"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [14, 15]}}
{"token": ["G-protein", "receptor", "kinase", "C0872043#ent", "<e1>", ")", "2", "phosphorylates", "G-protein", "coupled", "receptors", "including", "C1963718#ent", "<e2>", ",", "after", "agonist", "binding", ",", "as", "part", "of", "normal", "regulation", "desensitization", "."], "h": {"id": "C0872043", "name": "C0872043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1963718", "name": "C1963718#ent", "pos": [12, 13]}}
{"token": ["Based", "on", "genome", "searches", "and", "EST", "analyses", "the", "mouse", "and", "human", "C0017428#ent", "<e1>", "do", "not", "harbor", "GCAP4", "-", "8", "or", "C1413177#ent", "<e2>", "genes", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413177", "name": "C1413177#ent", "pos": [20, 21]}}
{"token": ["The", "effects", "of", "C0012373#ent", "<e1>", "on", "the", "cerebral", "blood", "flow", "cerebrovascular", "spasm", "studied", "in", "C0030883#ent", "<e2>", "anesthetized", "animals", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [14, 15]}}
{"token": ["At", "least", "two", "C0017337#ent", "<e1>", "encode", "isoenzymes", "of", "rat", "C1418488#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418488", "name": "C1418488#ent", "pos": [9, 10]}}
{"token": ["C0008174#ent", "<e1>", "frequently", "can", "control", "symptoms", "C0014547#ent", "<e2>", "psychic", "symptomatology", "at", "dosages", "less", "than", "those", "recommended", "for", "its", "use", "as", "an", "adjunctive", "anticonvulsant"], "h": {"id": "C0008174", "name": "C0008174#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [6, 7]}}
{"token": ["In", "eukaryotes", ",", "PPP", "(", "C1335403#ent", "<e1>", "one", "of", "the", "two", "known", "C0031686#ent", "<e2>", "families", "specific", "for", "Ser", "and", "Thr", "."], "h": {"id": "C1335403", "name": "C1335403#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [12, 13]}}
{"token": ["Ocular", "signs", "hypophosphatasia", "previously", "described", "are", "blue", "sclera", "C0235270#ent", "<e1>", "conjunctival", "calcification", "cataract", ",", "optic", "atrophy", "the", "complications", "of", "C0010278#ent", "<e2>", "."], "h": {"id": "C0235270", "name": "C0235270#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010278", "name": "C0010278#ent", "pos": [19, 20]}}
{"token": ["Nine", "paired", "litter", "mates", "received", "daily", "C3273618#ent", "<e1>", "injections", "of", "C0206141#ent", "<e2>", "."], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0206141", "name": "C0206141#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "diltiazem", "on", "various", "functional", "parameters", "were", "studied", "in", "bovine", "cultured", "adrenal", "chromaffin", "cells", "stimulated", "with", "the", "nicotinic", "receptor", "agonist", "dimethylphenylpiperazinium", "C0012847#ent", "<e1>", ")", "or", "with", "C0027867#ent", "<e2>", "Krebs-HEPES", "solutions", "containing", "high", "K+", "concentrations", "."], "h": {"id": "C0012847", "name": "C0012847#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [28, 29]}}
{"token": ["The", "effects", "of", "diltiazem", "on", "various", "functional", "parameters", "were", "studied", "in", "bovine", "cultured", "adrenal", "chromaffin", "cells", "stimulated", "with", "the", "C0012847#ent", "<e1>", "DMPP", ")", "or", "with", "C0027867#ent", "<e2>", "Krebs-HEPES", "solutions", "containing", "high", "K+", "concentrations", "."], "h": {"id": "C0012847", "name": "C0012847#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [25, 26]}}
{"token": ["SVV", "C3715179#ent", "<e1>", "63", "has", "51.6", "%", "homology", "at", "the", "C2917660#ent", "<e2>", "to", "VZV", "C3715179#ent", "<e1>", "63", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3715179", "name": "C3715179#ent", "pos": [1, 2]}}
{"token": ["The", "predicted", "132-kDa", "C1706299#ent", "<e1>", "of", "1,184", "C3539947#ent", "<e2>", "shows", "85", "%", "identity", "to", "the", "human", "C1706299#ent", "<e1>"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706299", "name": "C1706299#ent", "pos": [3, 4]}}
{"token": ["In", "this", "survey", ",", "we", "discuss", "the", "two", "major", "symptoms", "of", "C0221163#ent", "<e1>", "to", "occur", "during", "C1417325#ent", "<e2>", "oscillopsia", "and", "diplopia", "."], "h": {"id": "C0221163", "name": "C0221163#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [16, 17]}}
{"token": ["C0221163#ent", "<e1>", "a", "well", "recognized", "feature", "of", "C1417325#ent", "<e2>", "MS", ")", "."], "h": {"id": "C0221163", "name": "C0221163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [7, 8]}}
{"token": ["Mean", "deviation", "MD", ")", "and", "pattern", "standard", "deviation", "C1418591#ent", "<e1>", ")", "calculated", "by", "C1416423#ent", "<e2>", "correlated", "with", "those", "by", "HP", ",", "but", "MD", "by", "C1416423#ent", "<e2>", "showed", "larger", "defects", "in", "early", "glaucoma", "patients", "."], "h": {"id": "C1418591", "name": "C1418591#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416423", "name": "C1416423#ent", "pos": [13, 14]}}
{"token": ["We", "have", "analyzed", "the", "capacity", "of", "sensory", "and", "autonomic", "ganglia", "demonstrate", "latency-associated", "transcripts", "(", "C2347281#ent", "<e1>", ")", "following", "inoculation", "of", "the", "C0020641#ent", "<e2>", "the", "mouse", "eye", "with", "Herpes", "simplex", "virus", "type", "1", "HSV-1", ")", "."], "h": {"id": "C2347281", "name": "C2347281#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020641", "name": "C0020641#ent", "pos": [21, 22]}}
{"token": ["These", "include", "the", "human", "homologues", "of", "the", "P2Y1", ",", "C1418219#ent", "<e1>", "and", "P2Y4", "receptors", "the", "rat", "C1334043#ent", "<e2>", "of", "the", "P2Y6", "receptor"], "h": {"id": "C1418219", "name": "C1418219#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}}
{"token": ["Current", "opinions", "on", "the", "relationships", "between", "erythrocyte", "sodium-lithium", "countertransport", "kinetics", "and", "C0152171#ent", "<e1>", "hyperlipidaemia", "and", "C1442864#ent", "<e2>", "reviewed", "."], "h": {"id": "C0152171", "name": "C0152171#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [15, 16]}}
{"token": ["We", "generated", "C0021051#ent", "<e1>", "RMID", ")", "by", "transforming", "Aedes", "aegypti", "the", "C0282641#ent", "<e2>", "by", "the", "vitellogenin", "(", "Vg", ")", "promoter", "using", "the", "pBac[3xP3-EGFP", ",", "afm", "]", "vector", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0282641", "name": "C0282641#ent", "pos": [11, 12]}}
{"token": ["Hypergastrinaemia", "in", "combination", "with", "C0037036#ent", "<e1>", "exhibits", "clinical", "significance", "patients", "suffering", "from", "Zollinger-Ellison-syndrome", "or", "excluded", "C0039082#ent", "<e2>", "are", "due", "to", "autonomous", "gastrin", "release", "."], "h": {"id": "C0037036", "name": "C0037036#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [15, 16]}}
{"token": ["A", "decrease", "of", "cytokine-regulated", "C1334706#ent", "<e1>", "expression", "results", "in", "normalization", "of", "circulating", "C2001899#ent", "<e2>", "and", "MMP-3", "levels", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [12, 13]}}
{"token": ["However", ",", "C0172537#ent", "<e1>", "found", "in", "the", "same", "regions", "as", "C3273828#ent", "<e2>", "but", "not", "in", "the", "same", "cells", "."], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273828", "name": "C3273828#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "the", "adrenergic", "alpha", "2-antagonist", "atipamezole", ",", "the", "benzodiazepines", "chlordiaxepoxide", "and", "midazolam", "or", "GABA-A-antagonist", "bicucullin", "but", "not", "picrotoxin", "or", "C0075113#ent", "<e1>", "attenuated", "the", "response", "to", "C1705225#ent", "<e2>", "."], "h": {"id": "C0075113", "name": "C0075113#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [27, 28]}}
{"token": ["We", "demonstrate", "here", "that", "both", "C1334289#ent", "<e1>", "and", "chaperone", "functions", "the", "protein", "folding", "catalyst", "C4284026#ent", "<e2>", "PDI", ")", ",", "are", "essential", "for", "efficient", "refolding", "of", "denatured-reduced", "API", "(", "dr-API", ")", "."], "h": {"id": "C1334289", "name": "C1334289#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4284026", "name": "C4284026#ent", "pos": [14, 15]}}
{"token": ["The", "therapeutic", "effect", "intravenous", "injection", "of", "C0042071#ent", "<e1>", "(", "UK", "method", ")", "on", "acute", "myocardial", "infarction", "C0027051#ent", "<e2>", ")", "was", "studied", "and", "compared", "with", "the", "results", "of", "the", "therapeutic", "effect", "PTCR", "+", "PTCA", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [16, 17]}}
{"token": ["The", "main", "risk", "factors", "C0012702#ent", "<e1>", "induced", "hypoglycemia", "are", "a", "preexisting", "C1561643#ent", "<e2>", "advanced", "age", "and", "malnutrition", "."], "h": {"id": "C0012702", "name": "C0012702#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [11, 12]}}
{"token": ["Another", "constituent", "of", "C1095795#ent", "<e1>", "761", ",", "bilobalide", ",", "is", "a", "weak", "inhibitor", "of", "C0022614#ent", "<e2>", "receptor-activated", "current", "."], "h": {"id": "C1095795", "name": "C1095795#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [14, 15]}}
{"token": ["The", "C0003850#ent", "<e1>", "is", "a", "pathologic", "phenomena", "is", "caracterized", "by", "the", "C0162298#ent", "<e2>", "and", "enlargement", "of", "the", "arterial", "walls", "to", "the", "deposit", "of", "lipid", "carbohidrates", ",", "blood", "products", "calcium", "into", "the", "subendothelial", "space", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162298", "name": "C0162298#ent", "pos": [11, 12]}}
{"token": ["C0003850#ent", "<e1>", "determined", "by", "measuring", "the", "intima-media", "thickness", "C0162298#ent", "<e2>", "(", "beta", ")", "of", "the", "left", "and", "right", "common", "carotid", "arteries", "B-", "and", "M-mode", "ultrasonography", "30", "patients", "with", "one", "or", "more", "cardiovascular", "risk", "factors"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162298", "name": "C0162298#ent", "pos": [8, 9]}}
{"token": ["Smaller", "studies", "have", "identified", "increases", "in", "FVIII/vWF", "in", "association", "with", "C0038454#ent", "<e1>", "raised", "levels", "of", "C0032143#ent", "<e2>"], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [15, 16]}}
{"token": ["Myocardin-related", "transcription", "factor", "B", "C1537922#ent", "<e1>", ")", "is", "a", "member", "of", "a", "C0085303#ent", "<e2>", "Myocardin(Myocd),Myocardin-related", "transcription", "factor", "A(MRTF-A),MRTF-B", ")", "that", "provides", "tissue-specificity", "and", "potentiate", "SRF-dependent", "transcription", "."], "h": {"id": "C1537922", "name": "C1537922#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085303", "name": "C0085303#ent", "pos": [12, 13]}}
{"token": ["Results", "showed", "that", "oxLDL", "markedly", "stimulated", "C0166027#ent", "<e1>", "secretion", ",", "mRNA", "expression", ",", "and", "C0166027#ent", "<e1>", "promoter", "activity", "but", "C0872972#ent", "<e1>", "significantly", "inhibited", "the", "oxLDL-upregulated", "C0166027#ent", "<e1>", "expression", "."], "h": {"id": "C0872972", "name": "C0872972#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [6, 7]}}
{"token": ["The", "addition", "of", "C0960371#ent", "<e1>", "to", "spermatozoa", ",", "isolated", "and", "washed", "in", "the", "presence", "of", "the", "C1418544#ent", "<e2>", "increased", "PA2", "activity", "optimally", "with", "C0960371#ent", "<e1>", "concentrations", "of", "1.0", "-", "1.5", "units/assay", "."], "h": {"id": "C1418544", "name": "C1418544#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [3, 4]}}
{"token": ["Coadministration", "of", "C0034665#ent", "<e1>", "did", "not", "significantly", "alter", "the", "kinetic", "parameters", "and", "antihypertensive", "effect", "C0076166#ent", "<e2>", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0076166", "name": "C0076166#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "four", "major", "NCDs", "(", "hypertension", ",", "C0011849#ent", "<e1>", ",", "asthma", "and", "C0014547#ent", "<e2>", ")", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [13, 14]}}
{"token": ["C0015846#ent", "<e1>", "was", "complexed", "with", "C0011806#ent", "<e2>", "the", "intention", "to", "obtain", "parenteral", "solutions", "to", "provide", "prolonged", "analgesia", "following", "epidural", "administration"], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011806", "name": "C0011806#ent", "pos": [5, 6]}}
{"token": ["A", "62-year-old", "man", "with", "amphotericin", "B-resistant", "Candida", "krusei", "spondylodiscitis", "following", "an", "episode", "of", "C0877445#ent", "<e1>", "caused", "by", "the", "same", "strain", ",", "was", "successfully", "treated", "with", "C0537894#ent", "<e2>", "plus", "voriconazole", "."], "h": {"id": "C0877445", "name": "C0877445#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [25, 26]}}
{"token": ["We", "present", "a", "case", "of", "a", "premature", "infant", "persistent", "C0877445#ent", "<e1>", "despite", "antifungal", "treatment", "responded", "to", "therapy", "with", "C0537894#ent", "<e2>", ",", "an", "echinocandin", "antifungal"], "h": {"id": "C0877445", "name": "C0877445#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [18, 19]}}
{"token": ["Our", "results", "indicate", "that", "perturbation", "of", "XKCM1", "levels", "C2712370#ent", "<e1>", "the", "catastrophe", "frequency", "the", "rescue", "frequency", "cellular", "C0796074#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [17, 18]}}
{"token": ["Administration", "of", "PYR", "with", "C0796074#ent", "<e1>", "significantly", "C2712370#ent", "<e2>", "the", "mean", "saliva/plasma", "C0796074#ent", "<e1>", "ratio", "from", "0.265", "to", "0.358", "suggesting", "an", "increase", "in", "free", "C0796074#ent", "<e1>", "with", "PYR", "therapy"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0796074", "name": "C0796074#ent", "pos": [4, 5]}}
{"token": ["Thus", ",", "our", "data", "indicate", "that", "transcriptional", "regulation", "C1332411#ent", "<e1>", "contributes", "to", "the", "efficient", "apoptotic", "response", "C0003392#ent", "<e2>"], "h": {"id": "C1332411", "name": "C1332411#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [16, 17]}}
{"token": ["C0392938#ent", "<e1>", "also", "induced", "phosphorylation", "of", "C1332719#ent", "<e2>", "(", "Thr506", ")", "in", "HOS", "cells", "which", "is", "a", "substrate", "of", "Chk1", ",", "and", "its", "phosphorylation", "is", "known", "to", "be", "critical", "for", "S", "phase", "arrest"], "h": {"id": "C0392938", "name": "C0392938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332719", "name": "C1332719#ent", "pos": [6, 7]}}
{"token": ["The", "effects", "of", "beta-adernergic", "blocking", "C0000946#ent", "<e1>", "studied", "in", "23", "patients", "with", "C0002962#ent", "<e2>", "angiographically", "documented", "coronary", "artery", "disease"], "h": {"id": "C0000946", "name": "C0000946#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [12, 13]}}
{"token": ["Choline", "C0001390#ent", "<e1>", "displaced", "amacrine", "cells", "generated", "between", "C3811108#ent", "<e2>", "and", "E20", "."], "h": {"id": "C0001390", "name": "C0001390#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3811108", "name": "C3811108#ent", "pos": [8, 9]}}
{"token": ["Other", "C0020592#ent", "<e1>", "such", "as", "glutethimide", ",", "C0041964#ent", "<e2>", ",", "chloralose", ",", "chloral", "hydrate", "thiopentone", "do", "not", "have", "this", "ability", "even", "when", "administered", "in", "anaesthetic", "doses.3", "."], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041964", "name": "C0041964#ent", "pos": [7, 8]}}
{"token": ["The", "human", "sulfotransferase", "SULT", ")", "2B1", "C0017337#ent", "<e1>", "is", "a", "member", "of", "the", "C1512213#ent", "<e2>", "gene", "family", "encodes", "two", "isoforms", ",", "SULT2B1a", "and", "SULT2B1b", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1512213", "name": "C1512213#ent", "pos": [13, 14]}}
{"token": ["The", "nucleotide", "sequences", "the", "mglA", "and", "mglC", "C0017337#ent", "<e1>", "of", "Salmonella", "typhimurium", "St", ")", "C1512213#ent", "<e2>", "have", "been", "determined", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1512213", "name": "C1512213#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "carrageenan", "induced", "an", "upregulation", "of", "the", "adhesion", "molecules", "C1706544#ent", "<e1>", "and", "P-selectin", ",", "as", "well", "as", "nitrotyrosine", "and", "poly(ADP-ribose)", "synthetase", "C0032405#ent", "<e2>", ")", "as", "determined", "by", "immunohistochemical", "analysis", "lung", "tissues"], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032405", "name": "C0032405#ent", "pos": [22, 23]}}
{"token": ["Virological", "investigations", "that", "virologically", "unclarified", "(", "and", ",", "hence", ",", "vaccine-induced", ")", "C0236811#ent", "<e1>", "not", "occur", "more", "frequently", "in", "C3540638#ent", "<e2>", "vaccines", "than", "in", "unvaccinated", "persons.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0236811", "name": "C0236811#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540638", "name": "C3540638#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "that", "longstanding", "right", "middle", "lobe", "in", "C0004096#ent", "<e1>", "children", "is", "often", "associated", "with", "C0004623#ent", "<e2>"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [15, 16]}}
{"token": ["The", "activity", "of", "C1418571#ent", "<e1>", "was", "significantly", "higher", "in", "the", "extensor", "digitorum", "longus", "C1416870#ent", "<e2>", ")", "muscles", ",", "but", "not", "the", "soleus", "muscles", "of", "the", "peptide-treated", "dystrophic", "mice", "to", "the", "corresponding", "controls", "."], "h": {"id": "C1418571", "name": "C1418571#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416870", "name": "C1416870#ent", "pos": [13, 14]}}
{"token": ["Allergic", "fungal", "sinusitis", "C2699751#ent", "<e1>", ")", "is", "a", "noninvasive", "disease", "by", "recurrent", "C0149512#ent", "<e2>", "."], "h": {"id": "C2699751", "name": "C2699751#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [12, 13]}}
{"token": ["To", "evaluate", "the", "efficacy", "and", "safety", "of", "C0126177#ent", "<e1>", "%", "as", "prophylactic", "treatment", "the", "ocular", "signs", "symptoms", "of", "C0009766#ent", "<e2>"], "h": {"id": "C0126177", "name": "C0126177#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "based", "upon", "a", "dose-response", "study", "this", "model", ",", "0.2", "%", "C0126177#ent", "<e1>", "selected", "for", "further", "evaluation", "in", "environmental", "seasonal", "C0009766#ent", "<e2>", "studies", "."], "h": {"id": "C0126177", "name": "C0126177#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [21, 22]}}
{"token": ["Racemic", "norephedrine", "dl-NOR", ")", ",", "is", "a", "C0031399#ent", "<e1>", "is", "pharmacologically", "classified", "as", "a", "mixed-acting", "C0039052#ent", "<e2>"], "h": {"id": "C0031399", "name": "C0031399#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [15, 16]}}
{"token": ["A", "powder", "solid", "dispersion", "system", "(", "SD", ")", "of", "C0021246#ent", "<e1>", "(", "IM", ")", "with", "C0728803#ent", "<e2>", "(", "CrosPVP", ")", "possesses", "good", "fluidity", "and", "can", "be", "used", "for", "tablet", "formulation"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0728803", "name": "C0728803#ent", "pos": [15, 16]}}
{"token": ["Osteopetrosis", "describes", "a", "heterogeneous", "group", "C0005944#ent", "<e1>", "characterized", "by", "a", "C0017327#ent", "<e2>"], "h": {"id": "C0005944", "name": "C0005944#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017327", "name": "C0017327#ent", "pos": [10, 11]}}
{"token": ["Biochemical", "studies", "on", "highly", "purified", "heart", "and", "adipose", "C0023816#ent", "<e1>", "suggest", "that", "these", "C3540772#ent", "<e2>", "have", "identical", "protein", "moieties", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [13, 14]}}
{"token": ["C0039070#ent", "<e1>", "occurs", "in", "people", "with", "C0600260#ent", "<e2>", "it", "is", "unusual", "to", "find", "a", "specific", "correctable", "lesion", "precipitating", "it", "."], "h": {"id": "C0039070", "name": "C0039070#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0600260", "name": "C0600260#ent", "pos": [6, 7]}}
{"token": ["We", "report", "two", "siblings", "with", "homozygous", "sickle-disease", "and", "von", "Willebrand's", "disease", "had", "recurrent", "cerebral", "infarctions", "stokes", ")", "and", "transient", "C0007787#ent", "<e1>", "an", "inherent", "inhibitory", "platelet", "effect", "their", "C1264041#ent", "<e2>", "and", "antiplatelet", "therapy"], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1264041", "name": "C1264041#ent", "pos": [27, 28]}}
{"token": ["Nippostrongylus", "brasiliensis", "found", "to", "be", "sensitive", "to", "C0039832#ent", "<e1>", ",", "tetramisole", "and", "levamisole", "but", "the", "broad", "spectrum", "C0003158#ent", "<e2>", "mebendazole", "was", "ineffective", "."], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [7, 8]}, "relation": "has_therapeutic_class", "t": {"id": "C0003158", "name": "C0003158#ent", "pos": [17, 18]}}
{"token": ["There", "were", "no", "side", "effects", "the", "C0006938#ent", "<e1>", "group", "but", "flushing", ",", "tachycardia", "and", "C0270697#ent", "<e2>", "were", "observed", "in", "4", "patients", "of", "the", "nifedipine", "group", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [14, 15]}}
{"token": ["C4041575#ent", "<e1>", ",", "a", "glycine", "site", "partial", "C2987634#ent", "<e2>", "inhibits", "[3H]Pro", "binding", "."], "h": {"id": "C4041575", "name": "C4041575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [7, 8]}}
{"token": ["R(+", ")", "C4041575#ent", "<e1>", ",", "a", "weak", "partial", "C2987634#ent", "<e2>", "at", "the", "glycine/NMDA", "receptor", "complex", ",", "has", "been", "shown", "to", "have", "anxiolytic-like", "actions", "on", "restraint", "stress-induced", "mesoprefrontal", "dopamine", "metabolism", "."], "h": {"id": "C4041575", "name": "C4041575#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}}
{"token": ["Targeting", "therapeutic", "genes", "the", "liver", "is", "essential", "to", "improve", "gene", "therapy", "protocols", "of", "C0012634#ent", "<e1>", "of", "some", "C0019247#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [17, 18]}}
{"token": ["C4288934#ent", "<e1>", "also", "known", "as", "type", "I", "pseudohypoaldosteronism", "C1705459#ent", "<e2>", ")", ",", "is", "a", "rare", "inherited", "disease", "by", "salt", "wasting", "dehydration", "and", "failure", "to", "thrive", "in", "the", "newborn", "."], "h": {"id": "C4288934", "name": "C4288934#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705459", "name": "C1705459#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "suggest", "that", "C3540579#ent", "<e1>", "phenotype", "cytokines", "up-regulate", "and", "Th2", "phenotype", "cytokines", "down-regulate", "the", "C0019158#ent", "<e2>", "chronic", "viral", "hepatitis"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [15, 16]}}
{"token": ["The", "studies", "presented", "in", "this", "report", "were", "designed", "to", "evaluate", "whether", "C0038317#ent", "<e1>", "activity", "of", "the", "C0031667#ent", "<e2>", "responsive", "to", "endotoxin", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "a", "single", "oral", "dose", "PLS", "on", "the", "termination", "of", "C0004238#ent", "<e1>", "were", "compared", "with", "an", "infusion", "of", "C0012702#ent", "<e2>", "(", "DISO", ")", "in", "a", "multicenter", "trial"], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0012702", "name": "C0012702#ent", "pos": [20, 21]}}
{"token": ["We", "had", "a", "patient", "with", "MG", "who", "developed", "symptomatic", "MG", "aggravation", "after", "C0004238#ent", "<e1>", "treatment", "with", "C0012702#ent", "<e2>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0012702", "name": "C0012702#ent", "pos": [16, 17]}}
{"token": ["The", "combination", "of", "trazodone", "and", "mianserin", "has", "no", "additive", "value", "each", "C1254351#ent", "<e1>", "alone", "in", "the", "control", "of", "C0087169#ent", "<e2>", "opiate-dependent", "mice", "undergoing", "detoxification", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0087169", "name": "C0087169#ent", "pos": [18, 19]}}
{"token": ["Further", "manifestations", "of", "this", "stage", "may", "be", "C0152025#ent", "<e1>", "in", "rare", "cases", "also", "progressive", "C0024025#ent", "<e2>", "cerebrovascular", "neuroborreliosis", "."], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024025", "name": "C0024025#ent", "pos": [14, 15]}}
{"token": ["Oral", "administration", "lactoferrin", "(", "C1416933#ent", "<e1>", ")", ",", "an", "antimicrobial", "and", "immunomodulatory", "protein", "shows", "a", "protective", "effect", "C0009450#ent", "<e2>", "possibly", "via", "immunomodulation", "of", "the", "host", "."], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [17, 18]}}
{"token": ["There", "is", "a", "recognized", "association", "between", "hairy", "cell", "leukemia", "generalized", "necrotizing", "vasculitis", "C0031036#ent", "<e1>", "however", ",", "this", "is", "the", "first", "case", "report", "isolated", "C0042384#ent", "<e2>", "associated", "with", "condition", "."], "h": {"id": "C0031036", "name": "C0031036#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [23, 24]}}
{"token": ["RNS", "demonstrated", "abnormal", "nerve", "hyperexcitability", "in", "29", "of", "36", "subjects", "(", "81", "%", ")", "with", "C0015674#ent", "<e1>", ",", "defined", "operationally", "by", "the", "presence", "of", "both", "C0023218#ent", "<e2>", "fasciculations", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0023218", "name": "C0023218#ent", "pos": [25, 26]}}
{"token": ["The", "usefulness", "of", "C0040963#ent", "<e1>", "was", "compared", "with", "the", "pure", "random", "search", "C1839730#ent", "<e2>", ")", "and", "simplex", "search", "(", "SS", ")", "."], "h": {"id": "C0040963", "name": "C0040963#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1839730", "name": "C1839730#ent", "pos": [12, 13]}}
{"token": ["T", "cells", "reactive", "with", "this", "C0027203#ent", "<e1>", "have", "been", "recently", "cloned", "from", "the", "livers", "with", "C0008312#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [15, 16]}}
{"token": ["We", "have", "purified", "the", "pyruvate", "dehydrogenase", "PDH", ")", "C0027203#ent", "<e1>", "from", "bovine", "heart", "showing", "that", "all", "C0008312#ent", "<e2>", "sera", "reacted", "with", "a", "74-kd", "band", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [16, 17]}}
{"token": ["Increases", "in", "the", "level", "of", "c-AMP", "observed", "following", "application", "of", "forskolin", ",", "C0022245#ent", "<e1>", "and", "VIP", "are", "decreased", "by", "C0006945#ent", "<e2>", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [19, 20]}}
{"token": ["Data", "from", "clinical", "records", "patients", "using", "C0040233#ent", "<e1>", "confirm", "the", "ocular", "hypotensive", "effect", "of", "the", "drug", "in", "C0149893#ent", "<e2>", "aphakic", "glaucoma", "ocular", "hypertension", "and", "when", "used", "in", "combination", "with", "various", "other", "forms", "of", "glaucoma", "therapy"], "h": {"id": "C0040233", "name": "C0040233#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0149893", "name": "C0149893#ent", "pos": [17, 18]}}
{"token": ["C1856689#ent", "<e1>", "FRDA", ")", ",", "a", "C0151313#ent", "<e2>", "is", "a", "progressive", "neurodegenerative", "disease", "associated", "with", "loss", "of", "large", "sensory", "neurons", "from", "the", "dorsal", "root", "ganglia"], "h": {"id": "C1856689", "name": "C1856689#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [6, 7]}}
{"token": ["The", "effects", "of", "FGL", "peptide", "are", "shown", "to", "depend", "on", "activation", "of", "FGFR", "and", "the", "MAPK", "and", "PI3K", "intracellular", "signalling", "pathways", "all", "three", "C0010536#ent", "<e1>", "being", "necessary", "for", "the", "effects", "of", "on", "neurite", "outgrowth", "C1420257#ent", "<e2>"], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [34, 35]}}
{"token": ["In", "contrast", ",", "the", "recovery", "of", "C1416867#ent", "<e1>", "was", "profoundly", "suppressed", "in", "the", "cases", "with", "C0018133#ent", "<e2>", "GVHD", ")", "and", "glucocorticoid", "administration"], "h": {"id": "C1416867", "name": "C1416867#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018133", "name": "C0018133#ent", "pos": [15, 16]}}
{"token": ["C1415525#ent", "<e1>", "He", "s", ")", "C0017337#ent", "<e2>", "encode", "transcriptional", "repressors", "function", "as", "downstream", "targets", "of", "activated", "Notch", "receptors", "cell", "fate", "decisions", "during", "tissue", "development"], "h": {"id": "C1415525", "name": "C1415525#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}}
{"token": ["C0035334#ent", "<e1>", "an", "important", "feature", "of", "C0126155#ent", "<e2>", "LCHAD", ")", "deficiency", ",", "a", "disorder", "of", "mitochondrial", "fatty", "acid", "beta-oxidation"], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0126155", "name": "C0126155#ent", "pos": [6, 7]}}
{"token": ["The", "gelatin", "binding", "assays", "demonstrate", "that", "a", "single", "copy", "of", "T2HU-2", "renders", "C0005220#ent", "<e1>", "capable", "of", "C0017237#ent", "<e2>"], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017237", "name": "C0017237#ent", "pos": [16, 17]}}
{"token": ["86", "patients", "with", "C0477611#ent", "<e1>", "149", "patients", "with", "C0029429#ent", "<e2>", "been", "studied", ",", "all", "of", "whom", "were", "treated", "with", "variable", "vibromagnetic", "field", "kinesitherapy", "."], "h": {"id": "C0477611", "name": "C0477611#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029429", "name": "C0029429#ent", "pos": [8, 9]}}
{"token": ["Compared", "with", "AE1", ",", "the", "COOH-terminal", "tail", "C1335836#ent", "<e1>", "interacted", "weakly", "with", "C1413043#ent", "<e2>", "."], "h": {"id": "C1335836", "name": "C1335836#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["In", "this", "report", ",", "we", "demonstrate", "that", "C1427969#ent", "<e1>", "and", "three", "other", "BTB-Kelch", "proteins", ",", "including", "C3814805#ent", "<e2>", ",", "ENC1", ",", "and", "Sarcosin", ",", "are", "ubiquitinated", "by", "a", "Cul3-dependent", "complex", "."], "h": {"id": "C1427969", "name": "C1427969#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3814805", "name": "C3814805#ent", "pos": [16, 17]}}
{"token": ["In", "an", "in", "vitro", "model", "of", "chondrocyte", "differentiation", ",", "human", "dermal", "fibroblasts", "hDFs", ")", "cultured", "in", "collagen", "sponges", "induced", "to", "express", "cartilage", "matrix", "C1417679#ent", "<e1>", "after", "7", "days", "'", "culture", "with", "demineralized", "bone", "powder", "C3813197#ent", "<e2>", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3813197", "name": "C3813197#ent", "pos": [34, 35]}}
{"token": ["The", "abundance", "of", "C1417092#ent", "<e1>", "mRNA", "in", "the", "C0342895#ent", "<e2>", ",", "mutant", "mice", "was", "about", "the", "same", "as", "that", "in", "C0342895#ent", "<e2>", ",", "wild-type", "mice", "."], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [8, 9]}}
{"token": ["The", "activities", "of", "citrate", "cleavage", "enzyme", "fatty", "acid", "synthetase", "C1417092#ent", "<e1>", "livers", "of", "rats", "C0342895#ent", "<e2>", "the", "glycerol-containing", "diets", "were", "dramatically", "increased", "."], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [14, 15]}}
{"token": ["Perifused", "islets", "isolated", "from", "C1263960#ent", "<e1>", "Px", "rats", "showed", "reduced", "insulin", "responses", "GLP-1", "and", "C1706514#ent", "<e2>", "."], "h": {"id": "C1263960", "name": "C1263960#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706514", "name": "C1706514#ent", "pos": [14, 15]}}
{"token": ["Vitamin", "E", "no", "effect", "on", "the", "decrease", "of", "reduced", "glutathione", "(", "C1260386#ent", "<e1>", ")", "or", "the", "increase", "of", "C0037688#ent", "<e2>", "content", "in", "lens", "incubated", "with", "high", "level", "glucose", "medium"], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "C0062705#ent", "<e1>", "seems", "to", "be", "safer", "than", "C0022245#ent", "<e2>", "in", "the", "treatment", "of", "bradyarrhythmias", "."], "h": {"id": "C0062705", "name": "C0062705#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "C0062705#ent", "<e1>", "on", "LV", "function", "similar", "to", "the", "response", "obtained", "with", "C0022245#ent", "<e2>", "."], "h": {"id": "C0062705", "name": "C0062705#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [14, 15]}}
{"token": ["Several", "population", "studies", "suggested", "a", "small", "but", "significantly", "increased", "risk", "of", "imprinting", "disorders", "like", "C0162635#ent", "<e1>", "Beckwith-Wiedemann", "syndrome", "and", "possibly", "transient", "neonatal", "C0011847#ent", "<e2>", "in", "children", "born", "through", "ARTs", "."], "h": {"id": "C0162635", "name": "C0162635#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [22, 23]}}
{"token": ["This", "reaction", "entails", "the", "condensation", "of", "glycine", "with", "succinyl-coenzyme", "A", "yield", "5-aminolevulinate", ",", "carbon", "dioxide", "CoA.", "Mutations", "in", "the", "C0002565#ent", "<e1>", "to", "a", "defective", "enzyme", "and", "are", "associated", "with", "erythropoietic", "disorder", "C0002896#ent", "<e2>"], "h": {"id": "C0002565", "name": "C0002565#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002896", "name": "C0002896#ent", "pos": [31, 32]}}
{"token": ["Community", "pharmacists", "an", "important", "role", "in", "assisting", "patients", "in", "choosing", "the", "most", "appropriate", "C3536840#ent", "<e1>", "for", "their", "C2963170#ent", "<e2>"], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2963170", "name": "C2963170#ent", "pos": [17, 18]}}
{"token": ["Direct", "sequencing", "the", "C1706109#ent", "<e1>", "a", "heterozygous", "C0017346#ent", "<e2>", "deletion", "mutation", "in", "exon", "2", "which", "results", "in", "in-frame", "deletion", "of", "glutamic", "acid", "c.232_234delGAG", ";", "p", "."], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [7, 8]}}
{"token": ["Immunohistochemical", "analysis", "that", "C1704945#ent", "<e1>", "was", "expressed", "in", "CD68-positive", "microglial", "cells", "C0669372#ent", "<e2>", "detected", "in", "glial", "fibrillary", "acidic", "protein", "astrocytes", "and", "in", "equal", "amounts", "in", "microglial", "cells"], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [11, 12]}}
{"token": ["Indeed", ",", "46", "per", "cent", "of", "those", "with", "new", "C0234355#ent", "<e1>", "which", "was", "non", "apical", "neither", "QRS", "change", "nor", "C0010290#ent", "<e2>", "appearance", "."], "h": {"id": "C0234355", "name": "C0234355#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010290", "name": "C0010290#ent", "pos": [19, 20]}}
{"token": ["Dominant", "mutations", "in", "the", "fibroblast", "growth", "factor", "receptor", "2", "FGFR2", ")", "gene", "have", "been", "recently", "identified", "as", "causes", "of", "four", "phenotypically", "distinct", "C0010278#ent", "<e1>", "including", "Crouzon", ",", "C0795998#ent", "<e2>", ",", "Pfeiffer", ",", "and", "Apert", "syndromes"], "h": {"id": "C0010278", "name": "C0010278#ent", "pos": [22, 23]}, "relation": "manifestation_of", "t": {"id": "C0795998", "name": "C0795998#ent", "pos": [27, 28]}}
{"token": ["Recently", ",", "mutations", "of", "the", "fibroblast", "growth", "factor", "receptor", "2", "FGFR2", ")", "gene", "have", "been", "associated", "with", "C0010278#ent", "<e1>", "conditions", "including", "Apert", ",", "Crouzon", ",", "C0795998#ent", "<e2>", ",", "and", "Pfeiffer", "syndromes"], "h": {"id": "C0010278", "name": "C0010278#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C0795998", "name": "C0795998#ent", "pos": [25, 26]}}
{"token": ["Activating", "mutations", "in", "fibroblast", "growth", "factor", "FGF", ")", "receptors", "are", "thought", "to", "cause", "C0010278#ent", "<e1>", "in", "Crouzon", ",", "Apert", ",", "C0795998#ent", "<e2>", ",", "Beare-Stevenson", ",", "and", "Muenke", "syndromes"], "h": {"id": "C0010278", "name": "C0010278#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0795998", "name": "C0795998#ent", "pos": [20, 21]}}
{"token": ["Our", "findings", "indicate", "that", "transcription", "of", "the", "C1332679#ent", "<e1>", "regulated", "by", "C1333571#ent", "<e2>", "and", "NF-kappaB", "through", "MEK", "and", "JNK", "MAPK", "pathways", "monocytoid", "cells"], "h": {"id": "C1332679", "name": "C1332679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [11, 12]}}
{"token": ["Systems", "such", "as", "C0085096#ent", "<e1>", "pulmonary", ",", "gastrointestinal", ",", "diabetes", ",", "malignancy", "and", "C3258052#ent", "<e2>", "not", "frequent", "."], "h": {"id": "C0085096", "name": "C0085096#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3258052", "name": "C3258052#ent", "pos": [13, 14]}}
{"token": ["As", "compared", "with", "other", "pyridoxal-phosphate-containing", "C3541394#ent", "<e1>", ",", "this", "synthase", ",", "like", "serine", "sulphhydrase", "C0010662#ent", "<e2>", "has", "more", "stringent", "requirement", "as", "to", "coenzyme", "structure"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010662", "name": "C0010662#ent", "pos": [14, 15]}}
{"token": ["C1639494#ent", "<e1>", "is", "used", "in", "dermatology", "to", "treat", "inflammatory", "dermatoses", "as", "C0011608#ent", "<e2>", "pyoderma", "gangrenosum", "and", "was", "formerly", "the", "treatment", "of", "choice", "for", "acne", "conglobata"], "h": {"id": "C1639494", "name": "C1639494#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011608", "name": "C0011608#ent", "pos": [11, 12]}}
{"token": ["A", "prospective", "randomized", "trial", "performed", "comparing", "the", "efficacy", "of", "intraperitoneal", "irrigation", "with", "low", "molecular", "weight", "C2347652#ent", "<e1>", "'", "Betadine", "LMW", "'", ")", "(", "C0032857#ent", "<e2>", "LMW", ")", "in", "reducing", "the", "risk", "of", "intra-abdominal", "infectious", "complications"], "h": {"id": "C2347652", "name": "C2347652#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032857", "name": "C0032857#ent", "pos": [23, 24]}}
{"token": ["Overnight", "food", "deprivation", "decreased", "liver", "glucokinase", "GK", ")", ",", "ME", ",", "ATP-CL", ",", "and", "C0015923#ent", "<e1>", "activities", "and", "increased", "liver", "phosphoenolpyruvate", "carboxykinase", "PEPCK", ")", "and", "C0031651#ent", "<e2>", "in", "both", "young", "and", "adult", "animals", "."], "h": {"id": "C0015923", "name": "C0015923#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031651", "name": "C0031651#ent", "pos": [25, 26]}}
{"token": ["Se(IV)", "adsorption", "on", "C0885382#ent", "<e1>", "is", "insensitive", "to", "background", "C3536863#ent", "<e2>", "while", "the", "effect", "of", "ionic", "strength", "Se(VI)", "adsorption", "is", "not", "observed", ",", "which", "is", "attributed", "to", "the", "overloading", "of", "Se(VI)", "ions"], "h": {"id": "C0885382", "name": "C0885382#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [9, 10]}}
{"token": ["Neurocysticercosis", ",", "caused", "by", "the", "cestode", "Taenia", "solium", "is", "the", "most", "common", "C0030499#ent", "<e1>", "the", "human", "central", "nervous", "system", "leads", "to", "C0036572#ent", "<e2>", "."], "h": {"id": "C0030499", "name": "C0030499#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [21, 22]}}
{"token": ["Twenty-one", "subjects", "with", "mild", "or", "moderate", "C0020538#ent", "<e1>", "treated", "for", "12", "weeks", "with", "C0051696#ent", "<e2>", ",", "a", "new", "calcium", "antagonist", "the", "dihydropyridine", "group"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [13, 14]}}
{"token": ["To", "initiate", "the", "analysis", "of", "cis-acting", "elements", "governing", "the", "tissue-specific", "expression", "of", "the", "C1537665#ent", "<e1>", "genes", ",", "we", "cloned", "the", "human", "genes", "encoding", "C1412082#ent", "<e2>", "and", "MRP14", "."], "h": {"id": "C1537665", "name": "C1537665#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412082", "name": "C1412082#ent", "pos": [23, 24]}}
{"token": ["Hemolytic", "and", "C0302810#ent", "<e1>", "HUS", ")", "is", "characterized", "by", "the", "association", "of", "C0002878#ent", "<e2>", "sckizocytes", ",", "thrombopenia", "and", "renal", "involvement", "secondary", "to", "thrombotic", "microangiopathy"], "h": {"id": "C0302810", "name": "C0302810#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [12, 13]}}
{"token": ["Urinary", "C1705969#ent", "<e1>", "levels", "and", "two", "renal", "tubular", "dysfunction", "markers", "in", "urine", ",", "alpha1-microglobulin", "(", "alpha1-m", ")", "level", "and", "N-acetyl-beta-D-glucosaminidase", "(", "C1842690#ent", "<e2>", ")", "activity", ",", "were", "significantly", "elevated", "in", "the", "C1705969#ent", "<e1>", "group", "."], "h": {"id": "C1842690", "name": "C1842690#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [1, 2]}}
{"token": ["In", "conclusion", ",", "C1707236#ent", "<e1>", "genotype", "is", "associated", "with", "rates", "of", "C0020823#ent", "<e2>", "N-dechloroethylation", "in", "human", "liver", "and", "kidneys", "."], "h": {"id": "C1707236", "name": "C1707236#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [11, 12]}}
{"token": ["The", "activity", "of", "C0002570#ent", "<e1>", "toward", "L-leucinamide", "and", "of", "C0002515#ent", "<e2>", "toward", "L-leucyl-beta-naphthylamide", "was", "higher", "in", "human", "stomach", "cancer", "and", "lower", "in", "hepatic", "cancer", "tissue", "in", "normal", "stomach", "liver", ",", "respectively", "."], "h": {"id": "C0002570", "name": "C0002570#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002515", "name": "C0002515#ent", "pos": [9, 10]}}
{"token": ["We", "recorded", "the", "activity", "of", "142", "neurons", "during", "ipsilateral", "reaching", "movements", "that", "required", "anticipatory", "postural", "adjustments", "(", "C1858361#ent", "<e1>", ")", "in", "the", "supporting", "C0030196#ent", "<e2>", "to", "maintain", "equilibrium", "."], "h": {"id": "C1858361", "name": "C1858361#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [23, 24]}}
{"token": ["The", "concentration-response", "curves", "C3652599#ent", "<e1>", "dinitrate", "and", "C0022251#ent", "<e2>", "dinitrate", "for", "cyclic", "GMP", "accumulation", "were", "virtually", "identical", "."], "h": {"id": "C3652599", "name": "C3652599#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022251", "name": "C0022251#ent", "pos": [7, 8]}}
{"token": ["Occupational", "exposures", "interest", "were", "chromium", "compounds", "nickel", "compounds", "polycyclic", "aromatic", "hydrocarbons", "C3203102#ent", "<e1>", ")", ",", "silica", "and", "C0003949#ent", "<e2>", "."], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003949", "name": "C0003949#ent", "pos": [17, 18]}}
{"token": ["The", "interaction", "of", "C1335550#ent", "<e1>", "CaN", ")", "with", "C0038838#ent", "<e2>", "and", "hydrogen", "peroxide", "investigated", "."], "h": {"id": "C1335550", "name": "C1335550#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [8, 9]}}
{"token": ["Specific", "class", "I", "II", "histone", "deacetylases", "C0019643#ent", "<e1>", ")", "interact", "in", "vivo", "C1427193#ent", "<e2>", ",", "suggesting", "that", "C1427193#ent", "<e2>", "may", "functionally", "link", "these", "two", "classes", "of", "C0019643#ent", "<e1>", "."], "h": {"id": "C1427193", "name": "C1427193#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [6, 7]}}
{"token": ["The", "main", "mechanism", "of", "the", "antioxidative", "action", "of", "emoxipine", "in", "C0019099#ent", "<e1>", "was", "to", "enhance", "glutathione", "reductase", "C0763282#ent", "<e2>", "to", "lower", "the", "level", "on", "dienic", "conjugates", "in", "patients", "with", "Stage", "IIB", "CHF"], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0763282", "name": "C0763282#ent", "pos": [17, 18]}}
{"token": ["C0003405#ent", "<e1>", "subjects", "performed", "the", "task", "with", "subthalamic", "nucleus", "stimulation", "switched", "C1420342#ent", "<e2>", "and", "OFF", "."], "h": {"id": "C0003405", "name": "C0003405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [11, 12]}}
{"token": ["The", "patients", "were", "studied", "when", "immobile", "after", "12", "-", "18", "hours", "withdrawal", "from", "C0003405#ent", "<e1>", "OFF", ")", "and", "when", "more", "mobile", "after", "drugs", "(", "C1420342#ent", "<e2>", ")", "."], "h": {"id": "C0003405", "name": "C0003405#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420342", "name": "C1420342#ent", "pos": [24, 25]}}
{"token": ["It", "also", "suggests", "that", "aerobic", "capacity", "is", "more", "specifically", "linked", "to", "signs", "and", "symptoms", "of", "vasomotor", "origin", "C0235309#ent", "<e1>", "nausea", "and/or", "vomiting", ",", "C0270697#ent", "<e2>", ",", "and", "diaphoresis", "."], "h": {"id": "C0235309", "name": "C0235309#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [23, 24]}}
{"token": ["We", "report", "three", "cases", "of", "C1290138#ent", "<e1>", "four", "different", "neurological", "complications", "trigeminal", "neuropathy", "peripheral", "neuropathy", "C0007286#ent", "<e2>", "prolonged", "response", "to", "local", "anaesthesia"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [15, 16]}}
{"token": ["The", "quantitative", "effects", "of", "C0304441#ent", "<e1>", "exercise-induced", "asthma", "EIA", ")", "were", "evaluated", "in", "C0004096#ent", "<e2>", "children", "."], "h": {"id": "C0304441", "name": "C0304441#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}}
{"token": ["To", "study", "the", "effect", "of", "renal", "function", "the", "development", "of", "lipid", "and", "apolipoprotein", "abnormalities", "human", "C0022658#ent", "<e1>", "we", "have", "investigated", "75", "patients", "at", "different", "stages", "of", "C0035078#ent", "<e2>"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [26, 27]}}
{"token": ["C0015732#ent", "<e1>", "that", "started", "after", "the", "onset", "of", "an", "antihypertensive", "or", "C0040615#ent", "<e2>", "be", "due", "to", "alpha-receptor", "antagonist", "effects", "of", "drugs", "such", "as", "prazosin", "or", "chlorpromazine", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [11, 12]}}
{"token": ["Drug", "classes", "which", "induction", "of", "C0015732#ent", "<e1>", "has", "been", "proposed", "include", "alpha(1)-adrenoceptor", "antagonists", ",", "C0040615#ent", "<e2>", ",", "benzodiazepines", ",", "antidepressants", "and", "hormone", "replacement", "therapy", "postmenopausal", "women", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [14, 15]}}
{"token": ["Consistent", "with", ",", "our", "recent", "studies", "have", "demonstrated", "the", "existence", "of", "a", "protein", "tyrosine", "phosphatase", "C0085536#ent", "<e1>", ")", ",", "sensitive", "to", "the", "dipeptide", "aldehyde", "C0108192#ent", "<e2>", ",", "acting", "upstream", "of", "RhoA", "[", "5", "]", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0108192", "name": "C0108192#ent", "pos": [24, 25]}}
{"token": ["The", "CC", "chemokine", "44", "%", "identical", "at", "the", "C2917660#ent", "<e1>", "level", "to", "a", "C1332679#ent", "<e2>", "approximately", "20", "%", "identical", "to", "several", "mammalian", "CC", "chemokines", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332679", "name": "C1332679#ent", "pos": [13, 14]}}
{"token": ["We", "recently", "mapped", "two", "C0597336#ent", "<e1>", "have", "widespread", "effects", "on", "hippocampal", "architecture", "in", "mouse", ":", "C1335240#ent", "<e2>", "and", "Hipp5a", "."], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335240", "name": "C1335240#ent", "pos": [15, 16]}}
{"token": ["Thus", "circulating", "catecholamines", "are", "needed", "to", "compensate", "for", "the", "C0007681#ent", "<e1>", "action", "of", "hypercapnia", "on", "C0042420#ent", "<e2>", "vasoconstriction", "."], "h": {"id": "C0007681", "name": "C0007681#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042420", "name": "C0042420#ent", "pos": [15, 16]}}
{"token": ["Every", "affection", "of", "the", "larynx", "causes", "C0850149#ent", "<e1>", "and", "many", "C0012634#ent", "<e2>", "of", "the", "nose", "and", "paranasal", "sinuses", "do", "so", "as", "well", "."], "h": {"id": "C0850149", "name": "C0850149#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["Immunoelectron", "microscopy", "that", "among", "the", "C0010803#ent", "<e1>", "detected", "in", "suprabasal", "epidermolytic", "hyperkeratosis", "epidermis", "K1/K5/K10/K14/K16", ")", ",", "the", "aggregated", "tonofilaments", "predominantly", "expressed", "K1", "and", "C1416714#ent", "<e2>", "rather", "than", "other", "C0010803#ent", "<e1>", "."], "h": {"id": "C1416714", "name": "C1416714#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [5, 6]}}
{"token": ["From", "d", "0", "to", "7", ",", "pigs", "fed", "5", "%", "SDAP", "had", "greater", "(", "P", "<", "0.04", ")", "C3273406#ent", "<e1>", "than", "pigs", "fed", "the", "diet", "containing", "9", "%", "C3495801#ent", "<e2>", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3495801", "name": "C3495801#ent", "pos": [28, 29]}}
{"token": ["In", "conclusion", ",", "C0268576#ent", "<e1>", "might", "be", "an", "independent", "risk", "factor", "C3813548#ent", "<e2>", "and", "MS", "in", "diabetic", "subjects", "."], "h": {"id": "C0268576", "name": "C0268576#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3813548", "name": "C3813548#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "fiberoptic", "bronchoscopy", "be", "performed", "in", "evaluating", "patients", "with", "negative", "smears", "for", "AFB", "who", "are", "clinically", "suspected", "of", "having", "C0041296#ent", "<e1>", "before", "initiating", "a", "trial", "of", "C0003448#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [22, 23]}, "relation": "may_be_treated_by", "t": {"id": "C0003448", "name": "C0003448#ent", "pos": [29, 30]}}
{"token": ["C1416675#ent", "<e1>", "is", "most", "homologous", "to", "kallikriens", "and", "C0041236#ent", "<e2>", "."], "h": {"id": "C1416675", "name": "C1416675#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [8, 9]}}
{"token": ["A", "3-dimensional", "computer", "model", "C1416675#ent", "<e1>", ",", "based", "upon", "the", "crystal", "structure", "C0041236#ent", "<e2>", "has", "been", "generated", "and", "analyzed", "."], "h": {"id": "C1416675", "name": "C1416675#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [12, 13]}}
{"token": ["This", "investigation", "was", "carried", "out", "because", "of", "a", "clinical", "suspicion", "of", "drug", "interaction", "Propoxyphene", "(", "PRX", ")", "C0546849#ent", "<e1>", "and", "Carbamazepine", "(", "C0006949#ent", "<e2>", ")", "."], "h": {"id": "C0546849", "name": "C0546849#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006949", "name": "C0006949#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "they", "demonstrate", "that", "neither", "the", "soluble", "cGK", "Ibeta", "nor", "C0010531#ent", "<e1>", "able", "to", "substitute", "for", "C3494382#ent", "<e2>", "this", "cGMP-regulated", "function", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3494382", "name": "C3494382#ent", "pos": [17, 18]}}
{"token": ["The", "hisW", "mutations", "of", "Salmonella", "typhimurium", "highly", "pleiotropic", "mutations", "elevate", "his", "C0022895#ent", "<e1>", "expression", ",", "reduce", "C1420066#ent", "<e2>", "expression", ",", "alter", "stable", "RNA", "metabolism", "and", "confer", "defective", "growth", "properties"], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [16, 17]}}
{"token": ["The", "downstream", "signaling", "pathways", "diverge", "to", "C0752312#ent", "<e1>", "activation", "through", "activated", "protein", "kinase", "C", "expression", "of", "the", "C1333402#ent", "<e2>", "inositol", "triphosphate", "receptor-mediated", "Ca2", "+", "influx", "from", "extracellular", "fluid"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [17, 18]}}
{"token": ["Scatchard", "plot", "analyses", "also", "pointed", "to", "a", "possible", "non-competitive", "site", "for", "C0006864#ent", "<e1>", "interaction", "with", "C1334899#ent", "<e2>"], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [15, 16]}}
{"token": ["To", "examine", "the", "postoperative", "effect", "of", "C0013530#ent", "<e1>", "children", "who", "underwent", "surgery", "to", "C0014877#ent", "<e2>", "and", "to", "find", "out", "whether", "it", "significantly", "reduced", "the", "residual", "esotropia"], "h": {"id": "C0013530", "name": "C0013530#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0014877", "name": "C0014877#ent", "pos": [13, 14]}}
{"token": ["Importantly", ",", "global", "miRNA", "C0072074#ent", "<e1>", "showed", "that", "C1709966#ent", "<e2>", "over-expression", "in", "cervical", "SCC", "appears", "to", "be", "of", "functional", "significance", "."], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709966", "name": "C1709966#ent", "pos": [8, 9]}}
{"token": ["Nonneurological", "systemic", "diseases", "i.e.", ",", "encephalopathy", ",", "C0243026#ent", "<e1>", ")", "can", "produce", "fluctuating", "C0005745#ent", "<e2>", "or", "eye", "movements", "can", "occasionally", "be", "confused", "with", "MG", "."], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [13, 14]}}
{"token": ["There", "was", "a", "proportional", "decrease", "in", "heart", "rate", "blood", "pressure", "both", "the", "isoflurane", "and", "and", "the", "C0018549#ent", "<e1>", "group", "with", "C1413682#ent", "<e2>", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [20, 21]}}
{"token": ["He", "was", "diagnosed", "C0017609#ent", "<e1>", "left", "diabetic", "retinopathy", "simple", "type", ")", ",", "and", "received", "C0012798#ent", "<e2>", ",", "beta-blockade", "and", "other", "anti-hypertensive", "drugs"], "h": {"id": "C0017609", "name": "C0017609#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [14, 15]}}
{"token": ["C0772200#ent", "<e1>", "(", "TGB", ")", "is", "effective", "in", "patients", "with", "C0014544#ent", "<e2>"], "h": {"id": "C0772200", "name": "C0772200#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [10, 11]}}
{"token": ["C0025887#ent", "<e1>", "is", "mainly", "catalyzed", "by", "CYP2D6", "and", "partially", "catalyzed", "by", "C1620185#ent", "<e2>", "."], "h": {"id": "C0025887", "name": "C0025887#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [11, 12]}}
{"token": ["During", "cytotoxic", "treatment", "of", "a", "child", "with", "leukemia", "we", "describe", "the", "longitudinal", "course", "ionized", "calcium", "a", "C0458219#ent", "<e1>", "hypocalcemia", "and", "C0020626#ent", "<e2>", "."], "h": {"id": "C0458219", "name": "C0458219#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020626", "name": "C0020626#ent", "pos": [20, 21]}}
{"token": ["The", "relationship", "between", "cold-insoluble", "complexes", ",", "or", "cryoglobulins", ",", "and", "C0035086#ent", "<e1>", "studied", "in", "rabbits", "with", "C0036830#ent", "<e2>", "with", "BSA", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036830", "name": "C0036830#ent", "pos": [16, 17]}}
{"token": ["The", "Protein", "Identification", "Resource", "(", "PIR", ")", "protein", "sequence", "bank", "was", "searched", "for", "sequence", "similarity", "known", "C0086376#ent", "<e1>", "and", "human", "DNA", "polymerase", "beta", "Pol", "beta", "or", "human", "C0012881#ent", "<e2>", "TdT", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012881", "name": "C0012881#ent", "pos": [27, 28]}}
{"token": ["We", "studied", "prospectively", "11", "C0282556#ent", "<e1>", "patients", "presenting", "to", "the", "Accident", "and", "Emergency", "department", "C0582415#ent", "<e2>"], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0582415", "name": "C0582415#ent", "pos": [14, 15]}}
{"token": ["Sixty-two", "C0282556#ent", "<e1>", "patients", "were", "studied", "for", "plasma", "endothelin-1", "levels", "during", "C0582415#ent", "<e2>"], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0582415", "name": "C0582415#ent", "pos": [11, 12]}}
{"token": ["The", "efficiency", "of", "C0022252#ent", "<e1>", "ISDN", ")", "therapy", "on", "61", "subjects", "with", "C0010068#ent", "<e2>", "angina", "pectoris", "postinfarction", "state", "myocardial", "insufficiency", "was", "examined", "."], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [12, 13]}}
{"token": ["According", "to", "the", "dosage", "interval", "C0022252#ent", "<e1>", "dinitrate", ",", "66", "patients", "with", "C0010068#ent", "<e2>", "divided", "into", "group", "A", "group", "B", "a", "random", ",", "control", "and", "double-blind", "method"], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [12, 13]}}
{"token": ["C0022252#ent", "<e1>", "dinitrate", "may", "be", "clinically", "useful", "in", "patients", "with", "C0010068#ent", "<e2>", "though", "their", "exercise", "performance", "is", "not", "significantly", "improved", "."], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [10, 11]}}
{"token": ["The", "term", "C0035086#ent", "<e1>", "often", "used", "in", "a", "generic", "sense", "to", "include", "C0026857#ent", "<e2>", "patients", "with", "chronic", "renal", "failure", "to", "secondary", "hyperparathyroidism"], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026857", "name": "C0026857#ent", "pos": [12, 13]}}
{"token": ["The", "enzymes", "poly(ADP-ribose)polymerase", "C1418269#ent", "<e1>", "cooperate", "to", "drive", "a", "histone", "shuttle", "mechanism", "in", "C0008546#ent", "<e2>", "."], "h": {"id": "C1418269", "name": "C1418269#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [13, 14]}}
{"token": ["Thus", "chronic", "insulin", "treatment", "causes", "upregulation", "of", "AT1", "receptors", "which", "evoked", "C0051844#ent", "<e1>", "II-induced", "stimulation", "of", "C1539778#ent", "<e2>", "and", "NKA", "."], "h": {"id": "C0051844", "name": "C0051844#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1539778", "name": "C1539778#ent", "pos": [16, 17]}}
{"token": ["Importantly", ",", "the", "survival", "rate", "RAGE", "knockout", "mice", "more", "than", "fourfold", "that", "of", "C2987364#ent", "<e1>", "mice", "in", "a", "septic", "shock", "model", "cecal", "ligation", "puncture", "(", "C1413769#ent", "<e2>", ")", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413769", "name": "C1413769#ent", "pos": [25, 26]}}
{"token": ["Carpal", "tunnel", "syndrome", "C0007286#ent", "<e1>", ")", "and", "other", "C0026857#ent", "<e2>", "MSDs", ")", "are", "common", "problems", "in", "general", "industry", "well", "as", "dental", "hygiene"], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026857", "name": "C0026857#ent", "pos": [8, 9]}}
{"token": ["We", "have", "identified", "a", "novel", "allele", "of", "a", "C0079429#ent", "<e1>", "for", "an", "APC/C", "subunit", ",", "C1413255#ent", "<e2>", "-", "183", ",", "in", "S.", "cerevisiae"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413255", "name": "C1413255#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "whether", "C0012177#ent", "<e1>", "intake", "is", "correlated", "with", "clinical", "proteinuria", "subjects", "with", "non-insulin-dependent", "diabetes", "mellitus", "C0011860#ent", "<e2>", ")", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "the", "qualitative", "and", "quantitative", "effects", "of", "C0012177#ent", "<e1>", "biomarkers", "of", "diabetic", "nephropathy", "a", "C0011860#ent", "<e2>", "mouse", "model", "BKS.cg-m", "+", "Lepr(db)/+Lepr(db", ")", "mice", ")", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [21, 22]}}
{"token": ["GH", "deficiency", "associated", "with", "increased", "prevalence", "of", "C0003850#ent", "<e1>", ",", "and", "recent", "data", "indicate", "a", "proatherogenic", "role", "for", "C0023816#ent", "<e2>", "LPL", ")", "in", "the", "arterial", "wall"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [18, 19]}}
{"token": ["When", "the", "outcome", "of", "the", "disease", "was", "compared", "with", "the", "expression", "of", "CT", ",", "C1332745#ent", "<e1>", ",", "NSE", ",", "CGRP", ",", "and", "C0039902#ent", "<e2>", ",", "no", "correlation", "could", "be", "found", "."], "h": {"id": "C1332745", "name": "C1332745#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039902", "name": "C0039902#ent", "pos": [22, 23]}}
{"token": ["C0009074#ent", "<e1>", "is", "effective", "therapy", "for", "C0006849#ent", "<e2>", "patients", "with", "neoplastic", "disease", "and", "may", "prevent", "the", "development", "of", "esophagitis", "."], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [6, 7]}}
{"token": ["Another", "C1416669#ent", "<e1>", ",", "identified", "as", "C1416669#ent", "<e1>", "C2987030#ent", "<e1>", ",", "was", "isolated", "from", "this", "fraction", "and", "shown", "to", "hydrolyze", "Abz-ALDMMISRP-EDDnp", ";", "C2987030#ent", "<e1>", "also", "specifically", "released", "T-kinin", "from", "purified", "T1/T2-kininogen", "after", "HPLC", "fractionation"], "h": {"id": "C1416669", "name": "C1416669#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987030", "name": "C2987030#ent", "pos": [8, 9]}}
{"token": ["Ischemic", "brain", "lesions", "C0023529#ent", "<e1>", "were", "equally", "distributed", "between", "C0162311#ent", "<e2>", "and", "SGA", "babies", "(", "10.5", "vs.", "3.7", "%", ",", "p", ">", "0.5", ")", "independently", "of", "body", "weight", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0023529", "name": "C0023529#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162311", "name": "C0162311#ent", "pos": [9, 10]}}
{"token": ["Brucellosis", ",", "C0006818#ent", "<e1>", ",", "echinococcosis", ",", "listeriosis", ",", "salmonellosis", ",", "C0040896#ent", "<e2>", ",", "and", "the", "respective", "causative", "agents", "tuberculosis", "due", "to", "Mycobacterium", "bovis", "and", "verotoxigenic", "Escherichia", "coli", "be", "included", "in", "monitoring", "."], "h": {"id": "C0006818", "name": "C0006818#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040896", "name": "C0040896#ent", "pos": [11, 12]}}
{"token": ["Phosphorylation", "of", "E2A-encoded", "proteins", "was", "also", "increased", "in", "aged", "B", "cell", "and", "pharmacologic", "inhibition", "of", "C1434639#ent", "<e1>", "resulted", "in", "a", "partial", "restoration", "of", "their", "C1336596#ent", "<e2>"], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [24, 25]}}
{"token": ["A", "26-year-old", "man", "with", "idiopathic", "hypereosinophilic", "syndrome", "HES", ")", "was", "treated", "with", "C0939537#ent", "<e1>", "mesylate", "following", "a", "5-year", "history", "of", "C0032950#ent", "<e2>"], "h": {"id": "C0939537", "name": "C0939537#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [20, 21]}}
{"token": ["Upon", "treatment", "with", "C0074732#ent", "<e1>", "rat", "brain", "synaptic", "vesicles", "lost", "C0101555#ent", "<e2>", "H+", "transport", "released", "major", "polypeptide", "components", "about", "72", ",", "57", ",", "41", ",", "34", "and", "33", "kDa", ")", "."], "h": {"id": "C0074732", "name": "C0074732#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [10, 11]}}
{"token": ["Those", "identified", "include", "K-", ",", "N-", ",", "and", "H-p21ras", ",", "ras-related", "GTP-binding", "proteins", "as", "C1366537#ent", "<e1>", "Gp", ")", ",", "nuclear", "lamin", "B", "prelamin", "A", "and", "the", "gamma", "subunits", "C0752348#ent", "<e2>"], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [28, 29]}}
{"token": ["C0026896#ent", "<e1>", "diagnosed", "and", "the", "patient", "was", "given", "C0034262#ent", "<e2>", ",", "immunoglobulines", "and", "prednisone", "with", "benefit", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0034262", "name": "C0034262#ent", "pos": [8, 9]}}
{"token": ["Blepharophimosis-ptosis-epicanthus", "inversus", "syndrome", "C0220663#ent", "<e1>", ")", "is", "an", "autosomal", "dominant", "disorder", "by", "blepharophimosis", ",", "C0005745#ent", "<e2>", "and", "epicanthus", "inversus"], "h": {"id": "C0220663", "name": "C0220663#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [14, 15]}}
{"token": ["In", "most", "cases", "of", "chronic", "or", "C0014122#ent", "<e1>", "to", "the", "C0014118#ent", "<e2>", "Streptococcus", "viridans", ",", "there", "exists", "a", "distinctive", "pathological", "lesion", "in", "some", "of", "the", "glomeruli", "due", "to", "bacterial", "emboli"], "h": {"id": "C0014122", "name": "C0014122#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "we", "demonstrate", "that", "a", "C0031727#ent", "<e1>", "that", "directs", "the", "phosphorylation", "of", "ankyrin", "in", "vivo", "coprecipitates", "with", "C3272754#ent", "<e2>", "complexes", "and", "has", "properties", "identical", "to", "CK2", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3272754", "name": "C3272754#ent", "pos": [20, 21]}}
{"token": ["Acute", "lower", "respiratory", "tract", "infections", "C0149725#ent", "<e1>", ")", "range", "from", "acute", "bronchitis", "acute", "exacerbations", "C0008677#ent", "<e2>", "pneumonia", "."], "h": {"id": "C0149725", "name": "C0149725#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [14, 15]}}
{"token": ["This", "review", "examines", "the", "role", "of", "telithromycin", "in", "C0149725#ent", "<e1>", "analyzing", "published", "data", "exacerbations", "of", "C0008677#ent", "<e2>", "community-acquired", "pneumonia", "asthma", "in", "adults", "."], "h": {"id": "C0149725", "name": "C0149725#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [15, 16]}}
{"token": ["Expression", "of", "C0087140#ent", "<e1>", "as", "measured", "by", "Fos-like", "immunoreactivity", "after", "C0387956#ent", "<e2>", "L-DOPA", "was", "also", "potentiated", "as", "compared", "with", "L-DOPA", "alone", ",", "both", "in", "striatum", "and", "globus", "pallidus", "the", "6-hydroxydopamine-lesioned", "side", "the", "brain", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0387956", "name": "C0387956#ent", "pos": [10, 11]}}
{"token": ["The", "results", "indicated", "that", "the", "activity", "of", "eGFP", "and", "the", "amounts", "of", "secreted", "C1332791#ent", "<e1>", "in", "HFCL/EG", "cells", "exposed", "to", "C1412244#ent", "<e2>", "increased", "as", "compared", "to", "non-ADM", "group", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412244", "name": "C1412244#ent", "pos": [20, 21]}}
{"token": ["Physiological", "interaction", "C1311257#ent", "<e1>", "with", "endogenous", "C1704884#ent", "<e2>", "was", "induced", "upon", "NGF", "stimulation", "in", "non-transfected", "cells", ",", "and", "co-localization", "was", "observed", "with", "confocal", "microscopy"], "h": {"id": "C1311257", "name": "C1311257#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704884", "name": "C1704884#ent", "pos": [6, 7]}}
{"token": ["The", "striking", "similarity", "of", "the", "PhCSEH", "formula", "in", "our", "eight", "cases", "and", "of", "some", "cases", "of", "C0004135#ent", "<e1>", ",", "all", "suffering", "from", "C1561643#ent", "<e2>", "suggests", "a", "common", "pathogenetic", "pathway", "these", "conditions", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "both", "angiotension-converting", "enzyme", "(ACE)", "inhibitors", "ACEi", ")", "and", "A", "II", "antagonists", "C0004135#ent", "<e1>", ")", "exert", "a", "specific", "nephroprotective", "effect", "both", "experimental", "and", "human", "C1561643#ent", "<e2>"], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [25, 26]}}
{"token": ["The", "six", "ongoing", "trials", "will", "provide", "important", "additional", "information", "on", "the", "effect", "of", "C0051696#ent", "<e1>", "in", "patients", "with", "C0018799#ent", "<e2>", "other", "etiologies", "."], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [18, 19]}}
{"token": ["and", "shengmaiye", "(", "C0873137#ent", "<e1>", "A.", "Mey", ",", "Ophiopogon", "japonicus", "and", "Schisandra", "chinensis", "Baill", "on", "C1417247#ent", "<e2>", "induced", "by", "adriamycin", "in", "SD", "rats", "."], "h": {"id": "C0873137", "name": "C0873137#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417247", "name": "C1417247#ent", "pos": [15, 16]}}
{"token": ["The", "C1332163#ent", "<e1>", "Shc", "was", "initially", "identified", "as", "an", "SH2", "containing", "C0694890#ent", "<e2>", "involved", "in", "growth", "factor", "signaling"], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "cell-associated", "immunoglobulin", "G", "IgG", ")", ",", "C1412931#ent", "<e1>", ",", "C3b", ",", "and", "C5b", "indicated", "that", "serum-resistant", "H.", "influenzae", "C4049728#ent", "<e2>", "accumulation", "by", "delaying", "the", "synthesis", "of", "C3b", "through", "the", "classical", "pathway"], "h": {"id": "C1412931", "name": "C1412931#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4049728", "name": "C4049728#ent", "pos": [20, 21]}}
{"token": ["In", "patients", "with", "radiological", "evidence", "of", "C0034067#ent", "<e1>", "bronchodilator", "drugs", "fenoterol", "and", "C0700580#ent", "<e2>", "a", "considerable", "increase", "in", "vital", "capacity", "reduction", "in", "residual", "volume", "."], "h": {"id": "C0034067", "name": "C0034067#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0700580", "name": "C0700580#ent", "pos": [12, 13]}}
{"token": ["A", "rare", "case", "of", "C0025235#ent", "<e1>", "all", "the", "cardinal", "signs", "the", "triad", ",", "including", "facial", "swelling", "facial", "nerve", "palsy", "C0155964#ent", "<e2>", ",", "is", "described", "."], "h": {"id": "C0025235", "name": "C0025235#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155964", "name": "C0155964#ent", "pos": [19, 20]}}
{"token": ["A", "possible", "role", "of", "C1415619#ent", "<e1>", "expression", "as", "a", "compensatory", "mechanism", "the", "C1415014#ent", "<e2>", "islets", "is", "presently", "unclear", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415014", "name": "C1415014#ent", "pos": [12, 13]}}
{"token": ["Formation", "of", "these", "metabolites", "was", "inhibited", "significantly", "(", ">", "50", "%", ")", "by", "13-cis", "retinoic", "acid", "a", "C1382144#ent", "<e1>", "but", "not", "by", "furafylline", ",", "C0034414#ent", "<e2>", "or", "ketoconazole", "."], "h": {"id": "C1382144", "name": "C1382144#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [24, 25]}}
{"token": ["The", "C0237795#ent", "<e1>", "effect", "of", "C0033497#ent", "<e2>", "was", "significantly", "greater", "in", "the", "cortisone-treated", "rats", "(", "Group", "VII", "than", "in", "Group", "IV"], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [5, 6]}}
{"token": ["However", ",", "this", "C0237795#ent", "<e1>", "response", "could", "be", "counteracted", "by", "C0033497#ent", "<e2>", "n", "=", "5", ")", "or", "by", "bilateral", "stellate", "ganglionectomy", "n", "=", "3", ")", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [10, 11]}}
{"token": ["The", "action", "of", "C0044667#ent", "<e1>", ",", "its", "10-alkyl", "derivatives", ",", "and", "their", "polyglutamates", "against", "C0040085#ent", "<e2>", "TMPS", ")", "from", "human", "acute", "myeloblastic", "leukemia", "examined", "."], "h": {"id": "C0044667", "name": "C0044667#ent", "pos": [3, 4]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0040085", "name": "C0040085#ent", "pos": [14, 15]}}
{"token": ["The", "5HT3", "receptor", "antagonist", "C0291772#ent", "<e1>", "has", "been", "tested", "in", "several", "trials", "on", "C0022104#ent", "<e2>", "IBS", ")", "patients", "."], "h": {"id": "C0291772", "name": "C0291772#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [13, 14]}}
{"token": ["We", "hypothesized", "that", "C0291772#ent", "<e1>", ",", "a", "selective", "5-HT3", "antagonist", "may", "provide", "symptomatic", "relief", "in", "C0022104#ent", "<e2>", "patients", "through", "a", "decrease", "in", "the", "amplitude", "of", "gastrointestinal", "contractions"], "h": {"id": "C0291772", "name": "C0291772#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [15, 16]}}
{"token": ["Rather", ",", "it", "correlates", "with", "reduced", "transcriptional", "induction", "C1417679#ent", "<e1>", "involved", "in", "DNA", "repair", "suggesting", "that", "the", "E3", "Ub", "ligase", "activity", "C1333723#ent", "<e2>", "mediates", "the", "transcriptional", "response", "DNA", "damage"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333723", "name": "C1333723#ent", "pos": [21, 22]}}
{"token": ["We", "studied", "the", "physiological", "features", "of", "patients", "with", "C0034888#ent", "<e1>", "different", "degrees", "of", "C0400839#ent", "<e2>", "determine", "whether", "these", "conditions", "are", "likely", "to", "form", "part", "of", "the", "same", "disorder", "."], "h": {"id": "C0034888", "name": "C0034888#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0400839", "name": "C0400839#ent", "pos": [13, 14]}}
{"token": ["It", "may", "be", "successfully", "applied", "to", "the", "treatment", "of", "C0034888#ent", "<e1>", "internal", "procidentia", "complicated", "by", "a", "C0400839#ent", "<e2>", "particularly", "when", "the", "use", "of", "synthetic", "material", "precluded", "after", "a", "rectal", "wound"], "h": {"id": "C0034888", "name": "C0034888#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0400839", "name": "C0400839#ent", "pos": [16, 17]}}
{"token": ["Sulindac", "induced", "more", "intestinal", "adhesions", "than", "any", "other", "C3536840#ent", "<e1>", "and", "was", "directly", "related", "to", "the", "cumulative", "dose", "C0038792#ent", "<e2>", "."], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [18, 19]}}
{"token": ["The", "C3536840#ent", "<e1>", "prescribed", "included", "naproxen", ",", "ibuprofen", ",", "C0038792#ent", "<e2>", ",", "indomethacin", ",", "piroxicam", ",", "and", "tolmetin", "."], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [9, 10]}}
{"token": ["The", "RCAN1", "protein", "previously", "called", "calcipressin", "1", "C2826583#ent", "<e1>", ")", "binds", "to", "calcineurin", ",", "a", "serine/threonine", "phosphatase", "C1418845#ent", "<e2>", ")", ",", "and", "inhibits", "its", "activity", "."], "h": {"id": "C2826583", "name": "C2826583#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418845", "name": "C1418845#ent", "pos": [17, 18]}}
{"token": ["Mnt", "is", "one", "of", "20", "genes", "deleted", "in", "a", "heterozygous", "fashion", "C0265219#ent", "<e1>", "MDS", ")", ",", "a", "C1855496#ent", "<e2>", "consists", "of", "severe", "neuronal", "migration", "defects", "and", "craniofacial", "dysmorphic", "features"], "h": {"id": "C0265219", "name": "C0265219#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C1855496", "name": "C1855496#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "certain", "C0796126#ent", "<e1>", "exert", "a", "dual", "contraceptive", "action", "spermatozoa", "by", "inhibiting", "both", "the", "C0014442#ent", "<e2>", "acrosin", "and", "sperm", "motility"], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["CaCl2", "5.4", "mM", "antagonized", "partially", "the", "axonal", "conduction", "block", "EGTA", "in", "Ringer's", "solution", "C1414518#ent", "<e1>", "increased", "the", "effect", "of", "C0070570#ent", "<e2>", "on", "axonal", "conduction", "block", "desheated", "sciatic", "nerve"], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0070570", "name": "C0070570#ent", "pos": [19, 20]}}
{"token": ["There", "was", "no", "difference", "in", "time", "required", "for", "diagnosis", "of", "carcinoma", "in", "men", "or", "women", "or", "in", "those", "with", "C0010481#ent", "<e1>", "virilization", "or", "C0027670#ent", "<e2>"], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0027670", "name": "C0027670#ent", "pos": [23, 24]}}
{"token": ["No", "response", "plasma", "ACTH", "and", "cortisol", "to", "o-CRF", "was", "seen", "in", "each", "one", "patient", "with", "C0010481#ent", "<e1>", "to", "an", "adrenocortical", "adenoma", "C0027670#ent", "<e2>", "but", "low", "response", "retesting", ")", ",", "isolated", "ACTH", "deficiency", "and", "Sheehan's", "syndrome"], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027670", "name": "C0027670#ent", "pos": [21, 22]}}
{"token": ["A", "search", "conducted", "for", "C3541307#ent", "<e1>", "mutations", "in", "kindreds", "with", "C0008928#ent", "<e2>", "deletions", ",", "insertions", ",", "and", "missense", "mutations", "these", "mutations", "are", "found", "to", "segregate", "with", "patients", "who", "are", "defined", "clinically", "as", "cleidocranial", "dysplastic"], "h": {"id": "C3541307", "name": "C3541307#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008928", "name": "C0008928#ent", "pos": [10, 11]}}
{"token": ["We", "screened", "approximately", "40", "kb", "of", "PPARG", "in", "93", "nondiabetic", "Hispanic", "women", "63", "responders", "and", "30", "nonresponders", ")", "with", "previous", "C0085207#ent", "<e1>", "had", "participated", "in", "the", "C1257987#ent", "<e2>", "In", "the", "Prevention", "Of", "Diabetes", "study"], "h": {"id": "C0085207", "name": "C0085207#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1257987", "name": "C1257987#ent", "pos": [26, 27]}}
{"token": ["Administering", "C0074722#ent", "<e1>", "potassium", ",", "or", "taking", "the", "C0064494#ent", "<e2>", "drug", "with", "meals", "are", "unproven", "remedies", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0064494", "name": "C0064494#ent", "pos": [8, 9]}}
{"token": ["H2B", "has", "two", "variants", ",", "C1415415#ent", "<e1>", "and", ".2", ",", "and", "H3", "presents", "three", "variants", ",", "C1415431#ent", "<e2>", ",", ".2", "and", ".3", "."], "h": {"id": "C1415415", "name": "C1415415#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415431", "name": "C1415431#ent", "pos": [16, 17]}}
{"token": ["Serum", "concentrations", "of", "immunoreactive", "pancreatic", "polypeptide", "IPP", ")", "were", "measured", "serially", "for", "7", "days", "after", "experimental", "induction", "of", "C0267940#ent", "<e1>", "dogs", "by", "infusion", "of", "C0028928#ent", "<e2>", "the", "pancreatic", "duct"], "h": {"id": "C0267940", "name": "C0267940#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [24, 25]}}
{"token": ["We", "show", "that", "while", "expression", "of", "C1417574#ent", "<e1>", "is", "C0907533#ent", "<e2>", "in", "permissive", "cells", ",", "no", "trace", "of", "C1417574#ent", "<e1>", "transcripts", "is", "found", "in", "inducible", "cells", "the", "myoblast", "stage"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [6, 7]}}
{"token": ["We", "found", "that", "C0907533#ent", "<e1>", "expression", "of", "Pax7", "in", "satellite-cell-derived", "myoblasts", "did", "not", "affect", "C1417574#ent", "<e2>", "expression", "or", "proliferation", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [14, 15]}}
{"token": ["The", "relative", "abundance", "of", "mRNAs", "for", "C0025831#ent", "<e1>", "SUV39H1", "and", "G9A", ")", "and", "for", "heterochromatin-associated", "protein", "C1413160#ent", "<e2>", ")", "differed", "significantly", "before", "and", "after", "activation", "of", "the", "bovine", "embryonic", "genome", "."], "h": {"id": "C0025831", "name": "C0025831#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413160", "name": "C1413160#ent", "pos": [16, 17]}}
{"token": ["The", "Nrf2", "(", "nuclear", "factor-erythroid", "2", "p45-related", "factor", "2", "transcription", "factor", "gene", "expression", "the", "GCLC", "(", "C1522376#ent", "<e1>", ",", "which", "is", "a", "key", "enzyme", "in", "glutathione", "synthesis", "and", "C1865138#ent", "<e2>", "(", "glutathione", "S-transferases", "via", "the", "ARE", "(", "antioxidant-response", "element", "."], "h": {"id": "C1522376", "name": "C1522376#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [28, 29]}}
{"token": ["Groups", "2", "3", "were", "C0342895#ent", "<e1>", "the", "diets", "mixed", "with", "500", "and", "1000", "ppm", "C0002260#ent", "<e2>", ",", "respectively", ",", "for", "7", "weeks", ",", "starting", "at", "6", "weeks", "of", "age", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002260", "name": "C0002260#ent", "pos": [14, 15]}}
{"token": ["The", "incidence", "of", "DMBA-induced", "mammary", "tumors", "was", "significantly", "reduced", "in", "rats", "C0342895#ent", "<e1>", "diets", "containing", "C0002260#ent", "<e2>", "but", "not", "in", "rats", "fed", "the", "diet", "containing", "indomethacin", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002260", "name": "C0002260#ent", "pos": [15, 16]}}
{"token": ["A", "case", "of", "C1263835#ent", "<e1>", "rubella", "virus", "the", "12th", "week", "of", "pregnancy", ",", "with", "an", "C0751598#ent", "<e2>", "level", "under", "2IU", "after", "24", "weeks", "pregnancy", "was", "followed", "by", "normal", "birth"], "h": {"id": "C1263835", "name": "C1263835#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751598", "name": "C0751598#ent", "pos": [15, 16]}}
{"token": ["C0084866#ent", "<e1>", "can", "activate", "C1415749#ent", "<e2>", "synergistically", "with", "other", "stresses", "and", "exhibits", "cytoprotection", "against", "subsequent", "exposures", "to", "other", "forms", "of", "lethal", "cell", "stress", "."], "h": {"id": "C0084866", "name": "C0084866#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415749", "name": "C1415749#ent", "pos": [4, 5]}}
{"token": ["The", "intracellular", "C0003451#ent", "<e1>", "action", "of", "C0751039#ent", "<e2>", "against", "BKV", "does", "not", "appear", "to", "be", "via", "inhibition", "of", "viral", "cell", "entry", "pathways"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [6, 7]}}
{"token": ["Glucose-6-phosphate", "dehydrogenase-normal", "adult", "volunteers", "infected", "with", "mosquito-bone", "Chesson", "strain", "vivax", "C0024530#ent", "<e1>", "were", "treated", "with", "chloroquine", "and", "C0033126#ent", "<e2>", "during", "the", "initial", "attack", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0033126", "name": "C0033126#ent", "pos": [17, 18]}}
{"token": ["This", "suggests", "that", "mutations", "in", "a", "different", "as", "yet", "unknown", "C0079429#ent", "<e1>", "or", "genes", "may", "lead", "to", "the", "early", "onset", "C1260959#ent", "<e2>", "phenotype", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1260959", "name": "C1260959#ent", "pos": [20, 21]}}
{"token": ["All", "the", "newly", "introduced", "systemic", "drugs", "such", "as", "fluconazole", ",", "itraconazole", "and", "C0771029#ent", "<e1>", ",", "have", "been", "well", "tolerated", "during", "the", "treatment", "of", "C0026946#ent", "<e2>", "neonates", "and", "infants", "."], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [12, 13]}, "relation": "may_prevent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [23, 24]}}
{"token": ["An", "increasing", "amount", "of", "data", "is", "available", "where", "C0771029#ent", "<e1>", "has", "been", "used", "in", "the", "paediatric", "population", "treat", "superficial", "C0026946#ent", "<e2>", "in", "particular", "tinea", "capitis"], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [19, 20]}}
{"token": ["Two", "cases", "of", "immune", "haemolytic", "anaemia", "C3854173#ent", "<e1>", "induced", "by", "C0028277#ent", "<e2>", "are", "reported", "."], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0028277", "name": "C0028277#ent", "pos": [10, 11]}}
{"token": ["We", "report", "here", "a", "case", "of", "acquired", "immune", "haemolytic", "anaemia", "C3854173#ent", "<e1>", "induced", "by", "second", "exposure", "to", "single", "capsule", "of", "C0028277#ent", "<e2>", "."], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0028277", "name": "C0028277#ent", "pos": [20, 21]}}
{"token": ["It", "is", "not", "known", "if", "prolonged", ",", "continuous", "treatment", "potent", "acid", "suppressants", "as", "C0028978#ent", "<e1>", "will", "lead", "to", "C0162316#ent", "<e2>", "lower", "body", "iron", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "Munc18", ",", "C1420554#ent", "<e1>", ",", "and", "high", "amounts", "the", "isoforms", "I", "C3273406#ent", "<e2>", "of", "synaptotagmin", "were", "also", "found", "in", "DRM", "."], "h": {"id": "C1420554", "name": "C1420554#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [13, 14]}}
{"token": ["C0020923#ent", "<e1>", "and", "indomethacin", "inhibited", "the", "production", "of", "thromboxane", "and", "C0356622#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0020923", "name": "C0020923#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [10, 11]}}
{"token": ["Blood", "ammonia", "2115", "micromol/L", "and", "C0002523#ent", "<e1>", "and", "organic", "acid", "analyses", "were", "consistent", "with", "C0268542#ent", "<e2>"], "h": {"id": "C0002523", "name": "C0002523#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268542", "name": "C0268542#ent", "pos": [14, 15]}}
{"token": ["A", "patient", "in", "whom", "mixed", "C0009782#ent", "<e1>", "association", "of", "C0151449#ent", "<e2>", "previously", "been", "diagnosed", ",", "experienced", "a", "syncopal", "attack"], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [9, 10]}}
{"token": ["Manipulations", "that", "blocked", "C1420232#ent", "<e1>", "exchange", "blocked", "the", "ability", "of", "C2936795#ent", "<e2>", "alkalinize", "the", "interior", "of", "NG108", "-", "15", "cells", "without", "blocking", "the", "ability", "of", "these", "agonists", "to", "attenuate", "cAMP", "accumulation", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936795", "name": "C2936795#ent", "pos": [10, 11]}}
{"token": ["In", "a", "RAD", "strain", "CPSs", "in", "the", "transcriptionally", "active", "MAT", "alpha", "are", "preferentially", "repaired", "relative", "to", "the", "inactive", "C4049597#ent", "<e1>", ",", "whilst", "repair", "of", "C0014230#ent", "<e2>", "III-sensitive", "sites", "is", "not", "preferential", "."], "h": {"id": "C4049597", "name": "C4049597#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014230", "name": "C0014230#ent", "pos": [24, 25]}}
{"token": ["A", "case", "of", "C0010043#ent", "<e1>", "a", "10-year-old", "Nigerian", "boy", "in", "which", "C0031669#ent", "<e2>", "achromobacter", "were", "isolated", "is", "reported", "."], "h": {"id": "C0010043", "name": "C0010043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [11, 12]}}
{"token": ["Among", "the", "three", "C2350558#ent", "<e1>", "steroids", ",", "only", "C1539372#ent", "<e2>", "with", "BSA", "conjugated", "at", "position", "3", "C1539372#ent", "<e2>", "-", "3-BSA", ")", "was", "effective", "in", "stimulating", "LHRH", "release", "in", "vitro"], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539372", "name": "C1539372#ent", "pos": [8, 9]}}
{"token": ["C0030552#ent", "<e1>", "patients", "with", "chronic", "obstructive", "pulmonary", "disease", "C0024117#ent", "<e2>", ")", "is", "of", "major", "clinical", "relevance", ";", "maximum", "inspiratory", "pressure", "generation", "an", "independent", "determinant", "of", "survival", "in", "severe", "C0024117#ent", "<e2>", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [8, 9]}}
{"token": ["Rehabilitation", "is", "the", "best", "treatment", "for", "C0030552#ent", "<e1>", "deconditioning", "in", "patients", "with", "C0024117#ent", "<e2>", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [12, 13]}}
{"token": ["Previous", "animal", "studies", "indicated", "that", "C4255305#ent", "<e1>", "effects", "are", "elicited", "by", "C0025384#ent", "<e2>", "in", "vitro", "subcutaneously", "and", "that", "it", "produces", "blanching", "of", "the", "skin", "if", "injected", "subcutaneously", "in", "humans", "."], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025384", "name": "C0025384#ent", "pos": [11, 12]}}
{"token": ["Comparative", "studies", "C0085170#ent", "<e1>", "and", "other", "new", "antihistamines", "(", "terfenadine", ",", "loratadine", "and", "C0700480#ent", "<e2>", ")", "indicated", "no", "or", "only", "minor", "differences", "in", "onset", "of", "clinical", "effect"], "h": {"id": "C0085170", "name": "C0085170#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700480", "name": "C0700480#ent", "pos": [13, 14]}}
{"token": ["Terfenadine", "and", "C0085170#ent", "<e1>", "are", "currently", "available", "in", "the", "United", "States", "and", "C0700480#ent", "<e2>", "and", "loratadine", ",", "currently", "under", "review", "at", "the", "Food", "and", "Drug", "Administration", ",", "are", "available", "in", "other", "countries", "."], "h": {"id": "C0085170", "name": "C0085170#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700480", "name": "C0700480#ent", "pos": [12, 13]}}
{"token": ["The", "increase", "of", "C0011860#ent", "<e1>", "and", "the", "decrease", "of", "C1333690#ent", "<e2>", "reversed", "when", "spontaneous", "activation", "occurred", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [9, 10]}}
{"token": ["We", "also", "demonstrated", "that", "C1413824#ent", "<e1>", "CUG-BP", ")", "binds", "a", "conserved", "C2698415#ent", "<e2>", "motif", "within", "a", "human", "cTNT", "MSE", "and", "positively", "regulates", "MSE-dependent", "exon", "inclusion", "."], "h": {"id": "C1413824", "name": "C1413824#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2698415", "name": "C2698415#ent", "pos": [11, 12]}}
{"token": ["Tetrandrine", ",", "a", "C0006684#ent", "<e1>", "is", "a", "C0002062#ent", "<e2>", "various", "pharmacological", "activities", "anti-tumor", "activity"], "h": {"id": "C0006684", "name": "C0006684#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002062", "name": "C0002062#ent", "pos": [7, 8]}}
{"token": ["Polymerization", "of", "chitin", "requires", "the", "presence", "of", "active", "chitin", "synthases", "C1537630#ent", "<e1>", ")", ",", "a", "group", "of", "C3541394#ent", "<e2>", "belonging", "to", "the", "family", "of", "beta-glycosyl", "transferases"], "h": {"id": "C1537630", "name": "C1537630#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["Color", "Doppler", "imaging", "performed", "to", "evaluate", "the", "venous", "stasis", "39", "orbits", ",", "including", "9", "C3887709#ent", "<e1>", "of", "20", "patients", "with", "C0015397#ent", "<e2>", "22", "orbits", "of", "11", "healthy", "subjects"], "h": {"id": "C3887709", "name": "C3887709#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [20, 21]}}
{"token": ["At", "least", "three", "pathological", "situations", "are", "associated", "with", "abnormal", "androgen", "receptor", "structure", "function", ":", "C0039585#ent", "<e1>", "AIS", ")", ",", "spinal", "and", "bulbar", "muscular", "atrophy", "C1705240#ent", "<e2>", ")", "and", "prostate", "cancer"], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [14, 15]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [24, 25]}}
{"token": ["Insulin", "resistance", "C0221155#ent", "<e1>", "predictors", "of", "advanced", "fibrosis", "obese", "patients", "with", "C0015696#ent", "<e2>", "NAFLD", ")", "."], "h": {"id": "C0221155", "name": "C0221155#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015696", "name": "C0015696#ent", "pos": [11, 12]}}
{"token": ["Serotonin", ",", "neuron-specific", "enolase", "NSE", ")", ",", "C0164005#ent", "<e1>", "PGP", "9.5", ")", ",", "and", "C1413393#ent", "<e2>", "N-CAM", ")", "all", "have", "been", "described", "as", "being", "present", "in", "the", "morphologically", "defined", "Type", "III", "taste", "cells", "rats", "."], "h": {"id": "C0164005", "name": "C0164005#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413393", "name": "C1413393#ent", "pos": [14, 15]}}
{"token": ["BALB/cByJ", "mice", "deficient", "in", "the", "short-chain", "acyl-CoA", "dehydrogenase", "C2826550#ent", "<e1>", ")", "enzyme", "due", "to", "a", "spontaneous", "mutation", "in", "C1412108#ent", "<e2>", "."], "h": {"id": "C2826550", "name": "C2826550#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412108", "name": "C1412108#ent", "pos": [18, 19]}}
{"token": ["Despite", "the", "inhibition", "of", "DHBV", "DNA", "replication", "ddDAPR", ",", "the", "DNA", "polymerase", "C0035379#ent", "<e1>", "activities", "of", "the", "C1335440#ent", "<e2>", "are", "found", "to", "remain", "active", "when", "tested", "on", "exogenous", "templates", "in", "activity", "gels"], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [17, 18]}}
{"token": ["Efforts", "to", "examine", "the", "biochemical", "mechanism", "for", "viral", "DNA", "synthesis", "been", "hampered", "by", "the", "failure", "to", "solubilize", "the", "C0035379#ent", "<e1>", "virions", "and", "to", "express", "the", "C1335440#ent", "<e2>", "in", "heterologous", "systems", "in", "an", "enzymatically", "active", "form"], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [25, 26]}}
{"token": ["We", "conducted", "a", "double-blind", ",", "placebo-controlled", "trial", "the", "efficacy", "of", "oral", "azidothymidine", "AZT", ")", "in", "282", "patients", "with", "the", "acquired", "immunodeficiency", "syndrome", "AIDS", ")", "manifested", "by", "Pneumocystis", "carinii", "C0032285#ent", "<e1>", "alone", ",", "or", "with", "advanced", "C0001857#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0001857", "name": "C0001857#ent", "pos": [35, 36]}}
{"token": ["We", "conclude", "that", "C1414143#ent", "<e1>", "is", "safe", "in", "patients", "with", "C0003507#ent", "<e2>", "angina", "pectoris"], "h": {"id": "C1414143", "name": "C1414143#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "the", "safety", "and", "image", "quality", "dipyridamole-thallium", "imaging", "(", "C1414143#ent", "<e1>", ")", "in", "excluding", "coronary", "artery", "disease", "a", "coronary", "artery", "bypass", "graft", "patients", "with", "C0003507#ent", "<e2>", "aortic", "valve", "replacement"], "h": {"id": "C1414143", "name": "C1414143#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [31, 32]}}
{"token": ["The", "selected", "C1510464#ent", "<e1>", "Crambin", "and", "Pancreatic", "Trypsin", "Inhibitor", "because", "of", "their", "small", "size", "numerous", "C1119970#ent", "<e2>", "data", "obtained", "by", "other", "authors", "."], "h": {"id": "C1510464", "name": "C1510464#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1119970", "name": "C1119970#ent", "pos": [15, 16]}}
{"token": ["However", ",", "intracellular", "C0599532#ent", "<e1>", "levels", "appear", "to", "influence", "the", "expression", "of", "c-fos", "and", "C1623430#ent", "<e2>", ",", "suggesting", "a", "redox-sensitive", "component", "in", "the", "signaling", "cascade", "modulates", "gene", "expression", "c-fos", "and", "C1623430#ent", "<e2>", "by", "asbestos", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [14, 15]}}
{"token": ["Transient", "reductions", "of", "C3273591#ent", "<e1>", "mRNA", "levels", "by", "various", "C4048284#ent", "<e2>", "and", "tandospirone", "is", "associated", "with", "impairment", "of", "coordinated", "movement", ",", "such", "as", "rota-rod", "performance", "and", "equilibrium", "."], "h": {"id": "C3273591", "name": "C3273591#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [9, 10]}}
{"token": ["In", "a", "first", "step", "to", "verify", "the", "physiological", "roles", "of", "C3273591#ent", "<e1>", "and", "mPer2", "genes", "the", "cerebellum", ",", "we", "examined", "the", "effects", "of", "C4048284#ent", "<e2>", "on", "the", "expression", "of", "the", "C3273591#ent", "<e1>", "and", "mPer2", "genes"], "h": {"id": "C3273591", "name": "C3273591#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [23, 24]}}
{"token": ["No", "known", "duodenal", "stenosis", "C2004435#ent", "<e1>", "in", "patients", "undergoing", "C1705827#ent", "<e2>", "for", "UGIB", "or", "LGIB", ",", "respectively", ",", "during", "the", "follow-up", "period", "."], "h": {"id": "C2004435", "name": "C2004435#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705827", "name": "C1705827#ent", "pos": [9, 10]}}
{"token": ["C0010646#ent", "<e1>", "and", "target", "C2717970#ent", "<e2>", "such", "as", "cathepsins", "B", "L", "have", "been", "implicated", "in", "malignant", "progression", "."], "h": {"id": "C0010646", "name": "C0010646#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [4, 5]}}
{"token": ["In", "functional", "studies", ",", "the", "ability", "of", "galanin", "and", "C1970023#ent", "<e1>", "induce", "neurite", "outgrowth", "dependent", "on", "activation", "of", "both", "protein", "kinase", "C", "C1370600#ent", "<e2>", "."], "h": {"id": "C1970023", "name": "C1970023#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [22, 23]}}
{"token": ["C0028064#ent", "<e1>", "A", "and", "C", ",", "and", "Gaucher", "disease", "glycolipid", "storage", "disorders", "by", "the", "systemic", "deposition", "C0017978#ent", "<e2>", ",", "i.e.", ",", "sphingomyelin", "in", "C0028064#ent", "<e1>", "A", "and", "C", "tissues", "glucosylceramide", "in", "Gaucher", "disease", ",", "respectively", "."], "h": {"id": "C0017978", "name": "C0017978#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0028064", "name": "C0028064#ent", "pos": [0, 1]}}
{"token": ["After", "the", "first", "year", "of", "C3273872#ent", "<e1>", ",", "Ss", "exhibited", "a", "mild", "increase", "in", "C0086132#ent", "<e2>"], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086132", "name": "C0086132#ent", "pos": [14, 15]}}
{"token": ["Neuronal", "injury", "determined", "through", "trypan", "blue", "dye", "exclusion", ",", "DNA", "fragmentation", "externalization", "of", "membrane", "PS", "residues", ",", "C0769345#ent", "<e1>", "activation", ",", "and", "the", "measurement", "of", "intracellular", "pH", "(", "C1704947#ent", "<e2>", ")", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [28, 29]}}
{"token": ["However", ",", "immunoreactive", "protein", "and", "steady-state", "messenger", "RNA", "encoding", "for", "C1412361#ent", "<e1>", "and", "5-LAP", "were", "increased", "by", "conditioning", "with", "C0011777#ent", "<e2>", "."], "h": {"id": "C1412361", "name": "C1412361#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [19, 20]}}
{"token": ["C0960371#ent", "<e1>", "treatment", "of", "the", "C1334506#ent", "<e2>", "abolished", "the", "binding", ",", "and", "fibronectin", "but", "not", "laminin", "was", "found", "to", "be", "a", "suitable", "target", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334506", "name": "C1334506#ent", "pos": [5, 6]}}
{"token": ["The", "roles", "of", "Vav", ",", "a", "GTP/GDP", "exchange", "factor", "upregulating", "Rho", "kinase", "activity", "and", "C1335280#ent", "<e1>", ",", "protein", "tyrosine", "phosphatase", "dephosphorylated", "Vav", "and", "subsequently", "inactivated", "C1335631#ent", "<e2>", "examined", "."], "h": {"id": "C1335280", "name": "C1335280#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335631", "name": "C1335631#ent", "pos": [25, 26]}}
{"token": ["Although", "there", "are", "no", "direct", "comparative", "studies", "the", "analysis", "of", "the", "results", "of", "different", "studies", "suggests", "that", "the", "C1366449#ent", "<e1>", "of", "ropinirole", "is", "superior", "to", "that", "of", "other", "C0242702#ent", "<e2>"], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0242702", "name": "C0242702#ent", "pos": [28, 29]}}
{"token": ["3", ")", "C0041236#ent", "<e1>", "2", "mg/ml", "yielded", "more", "inactive", "renin", "than", "C1418965#ent", "<e2>", "0.5", "mg/ml", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418965", "name": "C1418965#ent", "pos": [11, 12]}}
{"token": ["We", "concluded", "that", "C1337090#ent", "<e1>", "and", "P/CAF", "are", "important", "regulators", "of", "C1416524#ent", "<e2>", "expression", "in", "stratified", "squamous", "epithelial", "cells"], "h": {"id": "C1337090", "name": "C1337090#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416524", "name": "C1416524#ent", "pos": [11, 12]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "conduct", "a", "prospective", "population", "pharmacokinetic", "and", "pharmacodynamic", "evaluation", "of", "C0531104#ent", "<e1>", "during", "blinded", "comparisons", "of", "C0936150#ent", "<e2>", "treatment", "regimens", "uncomplicated", "multidrug-resistant", "falciparum", "malaria", "."], "h": {"id": "C0531104", "name": "C0531104#ent", "pos": [16, 17]}, "relation": "part_of", "t": {"id": "C0936150", "name": "C0936150#ent", "pos": [22, 23]}}
{"token": ["Genetic", "heterogeneity", "been", "demonstrated", "for", "ADCA", ",", "with", "four", "cloned", "genes", "SCA1", ",", "SCA2", ",", "SCA3/MJD", ",", "and", "C0752124#ent", "<e1>", ")", "and", "three", "mapped", "loci", "SCA4", ",", "C3811242#ent", "<e2>", "and", "SCA7", ")", "."], "h": {"id": "C0752124", "name": "C0752124#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3811242", "name": "C3811242#ent", "pos": [27, 28]}}
{"token": ["Here", "we", "report", "the", "isolation", "and", "characterization", "of", "the", "zebrafish", "C1704894#ent", "<e1>", "locus", "together", "with", "the", "identification", "of", "three", "neighboring", "C0017337#ent", "<e2>", ",", "IER5", ",", "MAP17", ",", "and", "MUPP1", "."], "h": {"id": "C1704894", "name": "C1704894#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["Like", "mammalian", "APAF-1", ",", "HAC-1", "can", "activate", "C0534519#ent", "<e1>", "in", "a", "C0059946#ent", "<e2>", "manner", "in", "vitro"], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [11, 12]}}
{"token": ["This", "study", "investigated", "three", "physiologic", "functions", "to", "be", "modulated", "by", "serotonin-temperature", ",", "food", "intake", "locomotor", "activity", "using", "the", "C0360055#ent", "<e1>", "m-chlorophenylbiguanide", "(", "m-CPBG", ")", ",", "and", "two", "5-HT3", "antagonists", "C0065809#ent", "<e2>", "and", "ondansetron", "."], "h": {"id": "C0360055", "name": "C0360055#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0065809", "name": "C0065809#ent", "pos": [29, 30]}}
{"token": ["During", "this", "time", "period", "the", "most", "remarkable", "co-localization", "of", "G-kinase", "and", "C1421451#ent", "<e1>", "was", "observed", "between", "1", "-", "2.5", "min", "stimulation", "with", "C1705725#ent", "<e2>", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [22, 23]}}
{"token": ["Exposure", "to", "bleomycin", "or", "C0033223#ent", "<e1>", "abolished", "the", "characteristic", "biphasic", "response", "C0015008#ent", "<e2>"], "h": {"id": "C0033223", "name": "C0033223#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015008", "name": "C0015008#ent", "pos": [11, 12]}}
{"token": ["However", ",", "about", "half", "of", "the", "large", "cells", "classified", "by", "C0720099#ent", "<e1>", "of", "action", "potential", "were", "depolarized", "by", "C1367551#ent", "<e2>", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1367551", "name": "C1367551#ent", "pos": [18, 19]}}
{"token": ["Many", "diseases", "may", "be", "associated", "with", "H.", "pylori", "e.g.", "vascular", "diseases", "autoimmune", "diseases", "C0162628#ent", "<e1>", "sideropenic", "anemia", "diabetes", ",", "Parkinson", "disease", "and", "C0006267#ent", "<e2>", "."], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [22, 23]}}
{"token": ["A", "distinctly", "conserved", "cassette", "of", "domains", "at", "the", "amino-end", "of", "papilins", "is", "C1512488#ent", "<e1>", "with", "a", "cassette", "of", "protein", "domains", "the", "carboxyl-end", "of", "the", "C1328825#ent", "<e2>", "subgroup", "of", "secreted", ",", "matrix-associated", "metalloproteases", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1328825", "name": "C1328825#ent", "pos": [24, 25]}}
{"token": ["Mildly", "affected", "individuals", "from", "C0268141#ent", "<e1>", "XP-G", ")", "possess", "single", "amino", "acid", "substitutions", "in", "the", "C1705470#ent", "<e2>", "adversely", "affects", "its", "3", "'", "endonuclease", "function", "nucleotide", "excision", "repair"], "h": {"id": "C0268141", "name": "C0268141#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705470", "name": "C1705470#ent", "pos": [15, 16]}}
{"token": ["The", "results", "suggest", "that", "C0006507#ent", "<e1>", "treatment", "induces", "specific", "C0022173#ent", "<e2>", "of", "drug-metabolizing", "enzymes", "and", "might", "modify", "the", "expression", "of", "toxicities", "of", "other", "chemicals", "."], "h": {"id": "C0006507", "name": "C0006507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [9, 10]}}
{"token": ["These", "effects", "were", "reversed", "by", "overexpression", "of", "C1418779#ent", "<e1>", "or", "-beta", ",", "indicating", "C4054191#ent", "<e2>", "dependence", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4054191", "name": "C4054191#ent", "pos": [13, 14]}}
{"token": ["Similarly", ",", "C0025506#ent", "<e1>", "demethylated", "by", "CYP2C19", "into", "estradiol", ",", "a", "C1142644#ent", "<e2>", "substrate", "for", "ortho-hydroxylation", ";", "there", "was", "significant", "stimulation", "of", "hydroxylation", "by", "combined", "2C19", "and", "3A4", "."], "h": {"id": "C0025506", "name": "C0025506#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}}
{"token": ["The", "use", "of", "capillary", "electrophoresis", "CE", ")", "for", "the", "determination", "of", "C1142644#ent", "<e1>", "activity", "with", "C0042523#ent", "<e2>", "as", "a", "substrate", "was", "investigated", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [15, 16]}}
{"token": ["Inhibitor/substrate", "probes", "for", "C1142644#ent", "<e1>", ",", "ketoconazole", ",", "troleandomycin", ",", "C0042523#ent", "<e2>", "and", "cyclosporin", ",", "or", "supporting", "agents", ",", "vincristine", "and", "prednisolone", ",", "inhibited", "etoposide", "3'-demethylation", "by", "human", "liver", "microsomes", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [3, 4]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [10, 11]}}
{"token": ["Experiments", "using", "C1417825#ent", "<e1>", "C-terminal", "deletion", "mutants", "showed", "that", "C3539947#ent", "<e2>", "to", "550", "are", "dispensable", "for", "repression", "."], "h": {"id": "C1417825", "name": "C1417825#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [9, 10]}}
{"token": ["Screening", "for", "C0011847#ent", "<e1>", "and", "trying", "to", "ensure", "that", "implant", "C1332838#ent", "<e2>", "are", "in", "metabolic", "control", "recommended", "to", "increase", "the", "chances", "of", "successful", "osseointegration", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332838", "name": "C1332838#ent", "pos": [10, 11]}}
{"token": ["These", "interactions", "between", "the", "adhesive", "component", "vitronectin", "and", "the", "serine", "protease", "C1424142#ent", "<e1>", "may", "relate", "to", "localized", "control", "of", "thrombin", "and/or", "C1522670#ent", "<e2>", "action", "at", "certain", "extravascular", "sites"], "h": {"id": "C1424142", "name": "C1424142#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1522670", "name": "C1522670#ent", "pos": [21, 22]}}
{"token": ["C0120726#ent", "<e1>", "was", "administered", "as", "prophylaxis", "for", "C0024530#ent", "<e2>", "to", "mine", "workers", "returning", "from", "endemic", "areas", "of", "Papua", "New", "Guinea"], "h": {"id": "C0120726", "name": "C0120726#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [7, 8]}}
{"token": ["We", "hypothesized", "that", "C1418620#ent", "<e1>", "PLA2G4A", ")", "expression", "is", "upregulated", "in", "granulosa", "cells", "C1367452#ent", "<e2>", ")", "at", "ovulation", "."], "h": {"id": "C1418620", "name": "C1418620#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [13, 14]}}
{"token": ["Recently", "a", "new", "depot", "preparation", "the", "long-acting", "somatostatin", "analogue", ",", "C0771414#ent", "<e1>", "Autogel", "was", "introduced", "for", "the", "treatment", "of", "C0001206#ent", "<e2>", "."], "h": {"id": "C0771414", "name": "C0771414#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [19, 20]}}
{"token": ["The", "project", "was", "set", "to", "determine", "the", "value", "of", "combined", "therapy", "C0771414#ent", "<e1>", "and", "terguride", "in", "patients", "with", "C0001206#ent", "<e2>"], "h": {"id": "C0771414", "name": "C0771414#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [18, 19]}}
{"token": ["In", "all", "three", "cases", "C1419789#ent", "<e1>", "developed", "before", "the", "beginning", "of", "remitting", "C1417325#ent", "<e2>", "showed", "no", "correlation", "with", "the", "exacerbations", "of", "the", "neurological", "disease", "with", "the", "degree", "of", "neurological", "function", "loss"], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [12, 13]}}
{"token": ["The", "C1417807#ent", "<e1>", "a", "peptide", "with", "C0042402#ent", "<e2>", "and", "natriuretic", "properties", "is", "synthesized", "and", "released", "by", "atrial", "myocytes"], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [6, 7]}}
{"token": ["HAT", "activities", "acetylating", "either", "histone", "H3", "SAGA", ",", "C0001457#ent", "<e1>", ",", "and", "NuA3", ")", "or", "C1706229#ent", "<e2>", ")", "stimulate", "HIV-1", "transcription", "preassembled", "nucleosomal", "templates", "in", "an", "acetyl", "CoA-dependent", "manner", "."], "h": {"id": "C0001457", "name": "C0001457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706229", "name": "C1706229#ent", "pos": [15, 16]}}
{"token": ["C0238421#ent", "<e1>", "animals", "decreases", "the", "antibody", "response", "especially", "if", "associated", "with", "C1510471#ent", "<e2>"], "h": {"id": "C0238421", "name": "C0238421#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1510471", "name": "C1510471#ent", "pos": [11, 12]}}
{"token": ["The", "action", "of", "kainate", "was", "partially", "suppressed", "by", "C0043775#ent", "<e1>", ",", "by", "calmodulin", "antagonists", "by", "C3494348#ent", "<e2>", "of", "calmodulin-dependent", "phosphatase"], "h": {"id": "C0043775", "name": "C0043775#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [15, 16]}}
{"token": ["We", "used", "siRNA", "knockdown", "of", "C3538682#ent", "<e1>", "to", "elucidate", "the", "impact", "of", "C3538682#ent", "<e1>", "inhibition", "on", "mPGES-2", "and", "C1846861#ent", "<e1>", "expression", ",", "as", "well", "as", "on", "PGE2", "production", "."], "h": {"id": "C3538682", "name": "C3538682#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1846861", "name": "C1846861#ent", "pos": [18, 19]}}
{"token": ["In", "recent", "years", "in", "this", "indication", "a", "new", "C0010858#ent", "<e1>", "is", "tested", "--", "C0377401#ent", "<e2>", "which", "when", "used", "in", "monotherapy", "achieves", "a", "therapeutic", "response", "16", "-", "-30", "%", "."], "h": {"id": "C0010858", "name": "C0010858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0377401", "name": "C0377401#ent", "pos": [13, 14]}}
{"token": ["To", "evaluate", "the", "effects", "of", "C0113572#ent", "<e1>", "on", "androgenized", "oligomenorrheic", "women", "with", "C0032460#ent", "<e2>", "32", "women", "with", "PCOS", "were", "recruited", "to", "an", "open", "study", "one-year", "duration", "."], "h": {"id": "C0113572", "name": "C0113572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [12, 13]}}
{"token": ["C0298346#ent", "<e1>", ",", "an", "inhibitor", "of", "mitogen-activated", "protein", "kinase", "C1370600#ent", "<e2>", ")", "kinase/extracellular", "signal-related", "kinase", "kinase", "1", "suppressed", "TGF-beta1-", "or", "H2O2-induced", "IL-6", "and", "AP-1", "activation", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [9, 10]}}
{"token": ["We", "report", "the", "case", "of", "a", "36-year-old", "female", "patient", "with", "C0011860#ent", "<e1>", "developed", "hypothyroidism", "of", "C0032002#ent", "<e2>", "giving", "birth", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [15, 16]}}
{"token": ["PitCA", "observed", "in", "the", "sera", "of", "C0011860#ent", "<e1>", "patients", "were", "suspected", "of", "being", "C0032002#ent", "<e2>", "specific", "and", "independent", "with", "islet", "cell", "antibodies", "ICA", ")", "and", "islet", "cell", "surface", "antibodies", "ICSA", ")", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [13, 14]}}
{"token": ["A", "leupeptin", "analogue", "Cbz-Leu-Leu-Leu-aldehyde", "(", "C0105729#ent", "<e1>", ")", ",", "inhibits", "both", "the", "autolytic", "activation", "C1120861#ent", "<e2>", "and", "fusion", "induced", "by", "A2C", "and", "Ca2", "+", "."], "h": {"id": "C0105729", "name": "C0105729#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1120861", "name": "C1120861#ent", "pos": [14, 15]}}
{"token": ["Ten", "subjects", "with", "C1298685#ent", "<e1>", "in", "10", "weeks", "of", "group", "C1412770#ent", "<e2>", "followed", "by", "4", "months", "of", "Therapeutic", "Interactive", "Voice", "Response", "(", "TIVR", ")", "."], "h": {"id": "C1298685", "name": "C1298685#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412770", "name": "C1412770#ent", "pos": [10, 11]}}
{"token": ["Sequencing", "of", "the", "C0007787#ent", "<e1>", "locus", "identified", "a", "756-bp", "C0079941#ent", "<e2>"], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [9, 10]}}
{"token": ["C0038013#ent", "<e1>", "AS", ")", "is", "a", "complex", ",", "potentially", "C3714552#ent", "<e2>", "disease", "that", "is", "insidious", "in", "onset", ",", "progressing", "to", "radiological", "sacroiliitis", "several", "years", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "addition", "of", "C1417740#ent", "<e1>", "Rat-1", "cells", "transfected", "with", "the", "neuromedin", "B", "preferring", "receptor", "activated", "C0170168#ent", "<e2>", "p74(raf-1", ")", "in", "a", "PKC-independent", "and", "pertussis", "toxin-insensitive", "manner", "."], "h": {"id": "C1417740", "name": "C1417740#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [16, 17]}}
{"token": ["Two", "C0017337#ent", "<e1>", "encoding", "the", "C0024545#ent", "<e2>", "glycolate", "oxidase", "have", "been", "linked", "to", "locus", "glc", "64.5", "min", ")", ",", "responsible", "for", "glycolate", "utilization", "in", "Escherichia", "coli"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024545", "name": "C0024545#ent", "pos": [5, 6]}}
{"token": ["We", "report", "on", "the", "case", "of", "a", "25-year-old", "female", "with", "severe", "systemic", "lupus", "erythematosus", "SLE", ")", "who", "presented", "with", "C0030312#ent", "<e1>", ",", "fever", ",", "arthralgia", "and", "C0000737#ent", "<e2>"], "h": {"id": "C0030312", "name": "C0030312#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [26, 27]}}
{"token": ["There", "is", "also", "a", "wish", "to", "understand", "the", "pathogenesis", "of", "C0005940#ent", "<e1>", "for", "example", "osteogenesis", "imperfecta", "C0019937#ent", "<e2>", "osteoporosis", "."], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019937", "name": "C0019937#ent", "pos": [16, 17]}}
{"token": ["C0279175#ent", "<e1>", "triiodothyronine", "had", "no", "effect", "C1522405#ent", "<e2>", "production", "in", "vitro"], "h": {"id": "C0279175", "name": "C0279175#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [6, 7]}}
{"token": ["These", "data", "suggest", "a", "role", "of", "the", "C3539709#ent", "<e1>", "the", "pathogenesis", "of", "C0524620#ent", "<e2>", "hypertensive", "patients", "."], "h": {"id": "C3539709", "name": "C3539709#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [12, 13]}}
{"token": ["Overexpression", "of", "the", "endoplasmic", "reticulum-anchored", "PtdIns(4)P", "phosphatase", "C1424716#ent", "<e1>", "did", "not", "affect", "C1413043#ent", "<e2>", "+", "oscillations", ",", "although", "it", "increased", "the", "C1413043#ent", "<e2>", "+", "efflux", "rate", "intracellular", "stores", "."], "h": {"id": "C1424716", "name": "C1424716#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["Finally", "we", "show", ",", "using", "immunohistochemistry", ",", "that", "greater", "than", "90", "%", "of", "C1538719#ent", "<e1>", "neurons", "in", "all", "regions", "where", "C1538719#ent", "<e1>", "is", "expressed", "contain", "C1366515#ent", "<e1>"], "h": {"id": "C1538719", "name": "C1538719#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366515", "name": "C1366515#ent", "pos": [25, 26]}}
{"token": ["C0016053#ent", "<e1>", "may", "mimic", "some", "of", "the", "symptoms", "of", "C0080040#ent", "<e2>", "a", "disorder", "characterized", "by", "new", "weakness", ",", "fatigue", ",", "and", "pain", "decades", "paralytic", "poliomyelitis"], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080040", "name": "C0080040#ent", "pos": [9, 10]}}
{"token": ["Cellular", "organelles", "architectures", "were", "better", "preserved", "in", "C0008455#ent", "<e1>", "eyes", "than", "those", "treated", "with", "hyaluronidase", "and", "C0062507#ent", "<e2>", "."], "h": {"id": "C0008455", "name": "C0008455#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0062507", "name": "C0062507#ent", "pos": [16, 17]}}
{"token": ["Lithium", "led", "to", "a", "statistically", "significant", "enhancement", "of", "the", "C0027868#ent", "<e1>", "blocking", "effects", "of", "suxamethonium", ",", "C0030310#ent", "<e2>", "and", "vecuronium", ",", "but", "not", "of", "the", "other", "myoneural", "blocking", "drugs", "."], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0030310", "name": "C0030310#ent", "pos": [16, 17]}}
{"token": ["Ceramidase", "activity", "not", "be", "demonstrated", "in", "the", "kidney", "and", "cerebellum", "from", "a", "deceased", "patient", "with", "C0268255#ent", "<e1>", "whereas", "the", "activities", "of", "six", "control", "acid", "hydrolase", "C3541394#ent", "<e2>", "appeared", "normal", "."], "h": {"id": "C0268255", "name": "C0268255#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [25, 26]}}
{"token": ["C0906802#ent", "<e1>", "inhibits", "this", "activity", "and", "modulates", "the", "transcription", "of", "several", "C0017337#ent", "<e2>", "."], "h": {"id": "C0906802", "name": "C0906802#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["We", "examined", "HGF", ",", "the", "HGF", "receptor", "c-Met", ")", ",", "C4284777#ent", "<e1>", ",", "matriptase", ",", "and", "the", "C0003015#ent", "<e2>", "HAI-1", "and", "HAI-2", ")", ",", "tissues", "from", "patients", "with", "breast", "cancer"], "h": {"id": "C4284777", "name": "C4284777#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [17, 18]}}
{"token": ["It", "was", "found", "that", "L-NAME", "and", "7-NI", "decreased", "the", "dose", "of", "NMDA", "necessary", "to", "produce", "C0234535#ent", "<e1>", "50", "%", "of", "animals", "(", "C1334076#ent", "<e2>", ")", "."], "h": {"id": "C0234535", "name": "C0234535#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334076", "name": "C1334076#ent", "pos": [22, 23]}}
{"token": ["To", "analyze", "the", "role", "of", "the", "C1332114#ent", "<e1>", "C3539598#ent", "<e2>", ",", "we", "constructed", "stably", "transformed", "cell", "lines", "C3539598#ent", "<e2>", "mutants", "with", "deletions", "of", "all", "or", "parts", "of", "the", "NLS", "and", "C1332114#ent", "<e1>"], "h": {"id": "C1332114", "name": "C1332114#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539598", "name": "C3539598#ent", "pos": [8, 9]}}
{"token": ["Cicletanine-induced", "relaxation", "was", "uninfluenced", "by", "pretreatment", "with", "C0033497#ent", "<e1>", ",", "ouabain", ",", "tetraethylammonium", ",", "procaine", ",", "C0021246#ent", "<e2>", ",", "cimetidine", "or", "tetrodotoxin", "but", "was", "antagonized", "by", "glibenclamide", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [16, 17]}}
{"token": ["Drooling", "is", "not", "induced", "by", "an", "excess", "of", "salivary", "but", "by", "C0021167#ent", "<e1>", ",", "in", "case", "of", "patients", "with", "C0394007#ent", "<e2>", "neurologically", "damaged", "."], "h": {"id": "C0021167", "name": "C0021167#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0394007", "name": "C0394007#ent", "pos": [19, 20]}}
{"token": ["We", "describe", "a", "case", "of", "interstitial", "hypoxaemiant", "pneumonitis", "related", "to", "C0086303#ent", "<e1>", "in", "a", "patient", "with", "the", "C0175704#ent", "<e2>", "a", "rare", "congenital", "disorder"], "h": {"id": "C0086303", "name": "C0086303#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0175704", "name": "C0175704#ent", "pos": [17, 18]}}
{"token": ["Genomic", "replacement", "an", "intronless", "C1332455#ent", "<e1>", "the", "benomyl", "sensitivity", "of", "C1424923#ent", "<e2>", "mutants", ";", "however", ",", "they", "remain", "temperature", "sensitive", ",", "implying", "multiple", "limiting", "factors", "for", "mitosis", "."], "h": {"id": "C1332455", "name": "C1332455#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424923", "name": "C1424923#ent", "pos": [10, 11]}}
{"token": ["The", "present", "studies", "evaluated", "whether", "residues", "lining", "the", "cavity", "also", "contribute", "to", "specificity", ",", "using", "C1367690#ent", "<e1>", "for", "the", "polypeptides", "parathyroid", "hormone", "C1705340#ent", "<e2>", ")", "and", "secretin", "as", "models", "."], "h": {"id": "C1367690", "name": "C1367690#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "C0074160#ent", "<e1>", "represents", "a", "new", "C1516869#ent", "<e2>", "shows", "a", "greater", "specificity", "for", "the", "D1", "receptor", "its", "predecessor", "SCH23390"], "h": {"id": "C0074160", "name": "C0074160#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [7, 8]}}
{"token": ["Tests", "on", "the", "30th", "and", "60th", "days", "revealed", "a", "statistically", "significant", "reduction", "in", "max/min", "C1417911#ent", "<e1>", "values", ",", "but", "no", "statistically", "significant", "variations", "in", "either", "cardiac", "frequency", "C0020615#ent", "<e2>", "before", "and", "after", "meals", "."], "h": {"id": "C1417911", "name": "C1417911#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [27, 28]}}
{"token": ["Formation", "of", "sequences", "by", "both", "C1335843#ent", "<e1>", "and", "the", "Z-DNA", "is", "required", "for", "effective", "chromatin", "remodeling", "the", "C1332789#ent", "<e2>", "promoter", "."], "h": {"id": "C1335843", "name": "C1335843#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332789", "name": "C1332789#ent", "pos": [17, 18]}}
{"token": ["Osteoarthritis", "is", "treated", "with", "variety", "of", "pharmacologic", "therapies", "including", "acetaminophen", ",", "traditional", "nonsteroidal", "anti-inflammatory", "drugs", "C1257954#ent", "<e1>", "intra-articular", "steroids", "viscosupplements", ",", "glucosamine", ",", "chondroitin", "sulfate", "capsaicin", ",", "and", "C3714649#ent", "<e2>", "."], "h": {"id": "C1257954", "name": "C1257954#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [28, 29]}}
{"token": ["We", "performed", "cell-free", "assays", "and", "confirmed", "that", "like", "C1705506#ent", "<e1>", ",", "ZNF313", "binds", "ubiquitin", "via", "an", "C1823597#ent", "<e2>", "UIM", ")", "."], "h": {"id": "C1705506", "name": "C1705506#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1823597", "name": "C1823597#ent", "pos": [16, 17]}}
{"token": ["The", "SH2", "domain", "the", "C3853712#ent", "<e1>", "which", "shares", "high", "amino", "acid-sequence", "homology", "with", "the", "SH2", "domain", "C1826328#ent", "<e2>", ",", "was", "less", "effective", "in", "activating", "the", "oncogenic", "potential", "of", "c-ABL", "."], "h": {"id": "C3853712", "name": "C3853712#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826328", "name": "C1826328#ent", "pos": [16, 17]}}
{"token": ["This", "pathway", "was", "activated", "by", "exposure", "of", "irradiated", "HUVECs", "to", "C1522505#ent", "<e1>", ",", "involving", "phosphorylation", "of", "FGFR", ",", "C0752313#ent", "<e2>", "and", "p44/42", "MAPK", "."], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [18, 19]}}
{"token": ["DHT", ",", "in", "doses", "of", "up", "to", "1.0", "mg/d", ",", "is", "effective", "in", "treating", "both", "the", "C0031111#ent", "<e1>", "the", "osteomalacic", "components", "of", "C0005940#ent", "<e2>", "patients", "undergoing", "hemodialysis", "."], "h": {"id": "C0031111", "name": "C0031111#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [22, 23]}}
{"token": ["C0354599#ent", "<e1>", "tinzaparin", ";", "innohep", ")", "is", "a", "low", "C0019139#ent", "<e2>", "LMWH", ")", "formed", "by", "the", "enzymatic", "degradation", "porcine", "unfractionated", "heparin", "(", "UFH", ")", "."], "h": {"id": "C0354599", "name": "C0354599#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [9, 10]}}
{"token": ["No", "colocalization", "of", "C1333343#ent", "<e1>", "was", "observed", "with", "the", "early", "endosomal", "markers", "rab4", "and", "C1419212#ent", "<e2>", "."], "h": {"id": "C1333343", "name": "C1333343#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419212", "name": "C1419212#ent", "pos": [14, 15]}}
{"token": ["A", "link", "between", "C1704928#ent", "<e1>", "oncogenes", "and", "C0086661#ent", "<e2>", "is", "suggested", "by", "the", "transformation", "synergy", "that", "is", "observed", "when", "C0086661#ent", "<e2>", "is", "expressed", "at", "high", "levels"], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [7, 8]}}
{"token": ["We", "suggest", "that", "changes", "in", "the", "C1704928#ent", "<e1>", ",", "bcr", "and", "C0086661#ent", "<e2>", "topology", "in", "the", "case", "of", "gamma", "irradiation", "not", "the", "effects", "of", "cell", "cycle"], "h": {"id": "C1704928", "name": "C1704928#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [11, 12]}}
{"token": ["Chronic", "alcohol", "intoxication", "accompanied", "by", "development", "of", "C0597745#ent", "<e1>", "by", "lower", "immunological", "indices", "lower", "activity", "of", "xenobiotic", "metabolism", "C3540017#ent", "<e2>", "in", "lymphocytes", "."], "h": {"id": "C0597745", "name": "C0597745#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [18, 19]}}
{"token": ["C4055175#ent", "<e1>", "treatment", "had", "no", "effect", "the", "activity", "of", "extracellular", "signal-regulated", "protein", "kinase", "C1705791#ent", "<e2>", ")", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "C4055175#ent", "<e1>", "strongly", "repressed", "the", "PMA-induced", "phosphorylation", "of", "C1705791#ent", "<e2>", ",", "JNK", ",", "and", "p38", "MAP", "kinase", "which", "were", "dependent", "on", "the", "PKC", "pathway", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [10, 11]}}
{"token": ["D.", "melanogaster", "C1422733#ent", "<e1>", "also", "differs", "from", "human", "C1706431#ent", "<e2>", "in", "the", "manner", "in", "which", "the", "peptidase", "cleaves", "tachykinin", ",", "GPSGFYGVR-amide", "."], "h": {"id": "C1422733", "name": "C1422733#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706431", "name": "C1706431#ent", "pos": [8, 9]}}
{"token": ["Reverse-transcription", "(RT)-PCR", "showed", "that", "this", "C0005223#ent", "<e1>", "is", "produced", "only", "in", "the", "C0036091#ent", "<e2>"], "h": {"id": "C0005223", "name": "C0005223#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [12, 13]}}
{"token": ["Parabens", "are", "C1136254#ent", "<e1>", "used", "in", "foods", ",", "cosmetics", "and", "C1708062#ent", "<e2>"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1708062", "name": "C1708062#ent", "pos": [10, 11]}}
{"token": ["Of", "the", "16", "genes", "evaluated", ",", "3", "(", "C2697821#ent", "<e1>", ",", "YEAF", ",", "and", "C3814451#ent", "<e2>", ")", "showed", "statistical", "difference", "P", "<", "0.05", ")", "between", "early", "and", "late", "cleaving", "embryos"], "h": {"id": "C2697821", "name": "C2697821#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3814451", "name": "C3814451#ent", "pos": [14, 15]}}
{"token": ["Suggesting", "transcriptional", "activity", "C1336666#ent", "<e1>", "interacts", "with", "the", "transcription", "factor", "C1335654#ent", "<e2>", "in", "the", "osteoclast", "nucleus"], "h": {"id": "C1336666", "name": "C1336666#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [10, 11]}}
{"token": ["C0039223#ent", "<e1>", "and", "Becker", "muscular", "dystrophies", "DMD", "and", "C0917713#ent", "<e2>", ")", "are", "two", "allelic", "recessive", "X-linked", "disorders"], "h": {"id": "C0039223", "name": "C0039223#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0917713", "name": "C0917713#ent", "pos": [8, 9]}}
{"token": ["C0015131#ent", "<e1>", "and", "thiopental", "had", "no", "effect", "either", "NET", "or", "C3814032#ent", "<e2>", "function", "."], "h": {"id": "C0015131", "name": "C0015131#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3814032", "name": "C3814032#ent", "pos": [10, 11]}}
{"token": ["Results", "demonstrated", "that", "C0257309#ent", "<e1>", "produced", "dose-dependent", "anxiolytic", "effects", "to", "that", "of", "the", "classical", "antianxiety", "agent", "C0012010#ent", "<e2>", "."], "h": {"id": "C0257309", "name": "C0257309#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [16, 17]}}
{"token": ["C2699890#ent", "<e1>", "tandospirone", ")", "is", "an", "C0040616#ent", "<e2>", "acts", "by", "combining", "with", "serotonin", "receptor", "5-hydroxytryptamine-1", "A", "[", "5-HT1A", "]", ")", "."], "h": {"id": "C2699890", "name": "C2699890#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040616", "name": "C0040616#ent", "pos": [6, 7]}}
{"token": ["In", "conclusion", ",", "these", "studies", "demonstrate", "that", "C1419048#ent", "<e1>", "be", "an", "important", "C0014442#ent", "<e2>", "in", "regulating", "the", "steady-state", "levels", "of", "D-serine", "in", "neocortical", "synaptosomes", "."], "h": {"id": "C1419048", "name": "C1419048#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["The", "most", "potent", "agents", "to", "reduce", "the", "incidence", "of", "azoxymethane-induced", "tumors", "were", "celecoxib", ",", "a", "protease", "inhibitor", "soy", ",", "C0002260#ent", "<e1>", "with", "piroxicam", ",", "C0032483#ent", "<e2>", "and", "a", "thiosulfonate", "."], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [24, 25]}}
{"token": ["46", "had", "classical", "diplegia", "23", "had", "mildly", "spastic", "diplegia", "without", "adductor", "spasms", ")", ",", "86", "had", "hemiplegia", ",", "26", "had", "C0013384#ent", "<e1>", "10", "had", "right-", "and", "four", "had", "left-sided", "hemiathetosis", "25", "had", "C0034372#ent", "<e2>", "."], "h": {"id": "C0013384", "name": "C0013384#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0034372", "name": "C0034372#ent", "pos": [32, 33]}}
{"token": ["The", "topical", "group", "agents", "such", "as", "sulfur", ",", "C0036079#ent", "<e1>", "the", "alpha-hydroxy", "acids", "while", "the", "systemic", "group", "C0000949#ent", "<e2>", ",", "clofazimine", ",", "ibuprofen", "and", "others", "."], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000949", "name": "C0000949#ent", "pos": [17, 18]}}
{"token": ["Our", "data", "suggest", "the", "existence", "of", "a", "disease", "spectrum", "of", "C1852502#ent", "<e1>", "including", "brain", "and", "eye", "abnormalities", "from", "C1418752#ent", "<e2>", "mutations", "."], "h": {"id": "C1852502", "name": "C1852502#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418752", "name": "C1418752#ent", "pos": [18, 19]}}
{"token": ["Niacin", "extended-release", "is", "a", "once-daily", ",", "fixed-dose", "combination", "of", "the", "C0020374#ent", "<e1>", "simvastatin", "and", "an", "C1414461#ent", "<e2>", "formulation", "of", "niacin", "(", "a", "B-complex", "vitamin", "."], "h": {"id": "C0020374", "name": "C0020374#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "describe", "a", "regulatory", "gene", "C3538758#ent", "<e1>", ",", "that", "is", "part", "of", "the", "4-HBA", "degradation", "C0017258#ent", "<e2>"], "h": {"id": "C3538758", "name": "C3538758#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017258", "name": "C0017258#ent", "pos": [16, 17]}}
{"token": ["Amongst", "women", "the", "common", "cause", "of", "vaginal", "discharge", "C0085166#ent", "<e1>", "caused", "by", "Trichomonas", "vaginalis", "Candida", "albicans", "anaerobic", "C0004623#ent", "<e2>", "bacterial", "vaginosis", "."], "h": {"id": "C0085166", "name": "C0085166#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "indicate", "that", "a", "single", "dose", "cetirizine", "provides", "a", "more", "effective", "and", "long", "acting", "suppression", "on", "wheal", "and", "flare", "reactions", "in", "C0042109#ent", "<e1>", "when", "compared", "to", "C0054340#ent", "<e2>", "and", "loratadine", "."], "h": {"id": "C0042109", "name": "C0042109#ent", "pos": [22, 23]}, "relation": "may_be_treated_by", "t": {"id": "C0054340", "name": "C0054340#ent", "pos": [27, 28]}}
{"token": ["Mutations", "in", "a", "gene", "on", "chromosome", "1", "C1424222#ent", "<e1>", ",", "have", "been", "reported", "recently", "to", "be", "associated", "with", "C0017361#ent", "<e2>", ",", "earlyonset", "Parkinson's", "disease"], "h": {"id": "C1424222", "name": "C1424222#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [18, 19]}}
{"token": ["The", "antisense", "riboprobe", "detected", "C1419764#ent", "<e1>", "mRNA", "only", "in", "the", "photoreceptor", "layer", "the", "protein", "product", "the", "C0017337#ent", "<e2>", "was", "present", "both", "in", "the", "photoreceptors", "and", "within", "the", "inner", "portions", "of", "the", "retina", "."], "h": {"id": "C1419764", "name": "C1419764#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["To", "lower", "the", "nasal", "ciliotoxicity", "of", "C0037500#ent", "<e1>", "SDC", ")", "in", "combination", "with", "cyclodextrins", "(", "C1705969#ent", "<e2>", ")", "."], "h": {"id": "C0037500", "name": "C0037500#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [15, 16]}}
{"token": ["The", "pharmacologic", "therapies", "a", "5", "alpha-reductase", "inhibitor", "finasteride", ")", "and", "three", "selective", "C0304512#ent", "<e1>", "terazosin", ",", "doxasozin", ",", "and", "C0257343#ent", "<e2>", ")", "."], "h": {"id": "C0304512", "name": "C0304512#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0257343", "name": "C0257343#ent", "pos": [19, 20]}}
{"token": ["Among", "clinically", "available", "C0304512#ent", "<e1>", "the", "medical", "management", "benign", "prostatic", "hyperplasia", "BPH", ")", ",", "C0257343#ent", "<e2>", "has", "a", "modest", "selectivity", "for", "alpha1A-", "and", "alpha1D-", "over", "alpha1B-ARs", "."], "h": {"id": "C0304512", "name": "C0304512#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0257343", "name": "C0257343#ent", "pos": [14, 15]}}
{"token": ["C1705940#ent", "<e1>", "is", "expressed", "only", "in", "freshly", "isolated", "C1882266#ent", "<e2>", "+", "cells", "and", "quickly", "diminishes", "during", "differentiation", "."], "h": {"id": "C1705940", "name": "C1705940#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1882266", "name": "C1882266#ent", "pos": [8, 9]}}
{"token": ["Phorbol", "12-myristate", "13-acetate-induced", "C1826724#ent", "<e1>", "activation", "following", "C0917964#ent", "<e2>", "treatment", "resulted", "in", "vesicular", "distribution", "of", "all", "AQP2", "kinase", "mutants", ",", "while", "all", "were", "still", "phosphorylated", "at", "Ser-256", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [7, 8]}}
{"token": ["Increased", "levels", "of", "endothelial", "P-selectin", "plasma", "VWF", "in", "C4255520#ent", "<e1>", ")", "compared", "with", "C2987364#ent", "<e2>", "(", "WT", ")", "mice", "indicated", "an", "elevated", "release", "of", "Weibel-Palade", "bodies"], "h": {"id": "C4255520", "name": "C4255520#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}}
{"token": ["An", "inhibitory", "antibody", "to", "C4255520#ent", "<e1>", "infused", "in", "C2987364#ent", "<e2>", "mice", "prolonged", "adhesion", "of", "platelets", "to", "endothelium", "and", "induced", "thrombi", "formation", "embolization", "in", "the", "activated", "microvenules", "."], "h": {"id": "C4255520", "name": "C4255520#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}}
{"token": ["TS", "disease", "a", "C1415522#ent", "<e1>", "to", "the", "deficiency", "of", "the", "lysosomal", "enzyme", "beta-hexosaminidase", "A", "C1327841#ent", "<e2>", ")", "(", "beta-N-acetylhexosaminidase", ",", "EC", ")", "."], "h": {"id": "C1415522", "name": "C1415522#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1327841", "name": "C1327841#ent", "pos": [14, 15]}}
{"token": ["It", "might", "represent", "a", "possible", "way", "of", "action", "of", "the", "drug", "in", "some", "C0021290#ent", "<e1>", "hyperbilirubinaemia", "and", "C0035344#ent", "<e2>"], "h": {"id": "C0021290", "name": "C0021290#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0035344", "name": "C0035344#ent", "pos": [17, 18]}}
{"token": ["This", "study", "shows", "that", "at", "equipotent", "beta", "1-blocking", "doses", ",", "C0033497#ent", "<e1>", ",", "but", "not", "C0116569#ent", "<e2>", ",", "produces", "significant", "increases", "in", "pulmonary", "reactivity", "methacholine", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0116569", "name": "C0116569#ent", "pos": [15, 16]}}
{"token": ["C0022245#ent", "<e1>", "or", "adrenaline", "infusions", "induced", "C0040479#ent", "<e2>", "inversion", "of", "the", "TU", "wave", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040479", "name": "C0040479#ent", "pos": [6, 7]}}
{"token": ["On", "the", "other", "hand", ",", "C0015530#ent", "<e1>", "reduce", "protection", "of", "the", "vascular", "endothelium", "C1414369#ent", "<e2>", "and", "reactive", "oxygen", "species", "which", "would", "promote", "organ", "damage"], "h": {"id": "C0015530", "name": "C0015530#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414369", "name": "C1414369#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "establish", "an", "additional", "role", "for", "the", "GDI", "protein", "namely", ",", "as", "a", "C0018296#ent", "<e1>", "GTPase", ")", "inhibitory", "protein", "for", "a", "C1455060#ent", "<e2>"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1455060", "name": "C1455060#ent", "pos": [22, 23]}}
{"token": ["In", "the", "present", "study", ",", "the", "protein", "product", "C1706383#ent", "<e1>", ")", "of", "the", "C1706383#ent", "<e1>", "used", "as", "a", "metabolic", "marker", "trace", "central", "neural", "pathways", "activation", "of", "carotid", "sinus", "nerve", "afferent", "fibers", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [8, 9]}}
{"token": ["To", "investigate", "the", "possible", "role", "of", "C1706383#ent", "<e1>", "in", "NGF-induced", "differentiation", ",", "activated", "mouse", "C1706383#ent", "<e1>", "introduced", "into", "PC-12", "cells", "electroporation", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [6, 7]}}
{"token": ["C4283853#ent", "<e1>", "83852", "is", "a", "murine", "monoclonal", "antibody", "preferentially", "inhibits", "the", "C1721278#ent", "<e2>", "epidermal", "growth", "factor", "EGF", ")", "to", "its", "receptor", "."], "h": {"id": "C4283853", "name": "C4283853#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1721278", "name": "C1721278#ent", "pos": [11, 12]}}
{"token": ["Superior", "mesenteric", "artery", "syndrome", "C0026847#ent", "<e1>", ")", "was", "the", "cause", "of", "C0038353#ent", "<e2>", "two", "of", "them", "."], "h": {"id": "C0026847", "name": "C0026847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038353", "name": "C0038353#ent", "pos": [11, 12]}}
{"token": ["Insulin-regulated", "aminopeptidase", "is", "a", "C0021699#ent", "<e1>", "to", "the", "M1", "family", "aminopeptidases", "and", "in", "insulin-responsive", "cells", "colocalizes", "with", "C1420175#ent", "<e2>", "in", "specific", "intra-cellular", "vesicles"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [17, 18]}}
{"token": ["From", "primary", "structure", "comparison", ",", "the", "pancreatic", "lipase", "family", "now", "divided", "into", "three", "subgroups", ":", "classical", "pancreatic", "lipases", "C1418709#ent", "<e1>", "RPI", ")", "and", "C1418710#ent", "<e2>", "RP2", ")", "."], "h": {"id": "C1418709", "name": "C1418709#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1418710", "name": "C1418710#ent", "pos": [23, 24]}}
{"token": ["Two", "of", "the", "four", "C1417679#ent", "<e1>", "map", "to", "chromosome", "I", "C1853262#ent", "<e2>", "in", "the", "left", "arm", "6", "cM", "of", "ura1", ",", "and", "ste9", "in", "the", "right", "arm", "3", "cM", "of", "ade2", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1853262", "name": "C1853262#ent", "pos": [10, 11]}}
{"token": ["C1366763#ent", "<e1>", ",", "a", "C.elegans", "homologue", "of", "C1538820#ent", "<e2>", ",", "physically", "interacts", "with", "SPR-5", "."], "h": {"id": "C1366763", "name": "C1366763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538820", "name": "C1538820#ent", "pos": [7, 8]}}
{"token": ["Severe", "systemic", "hypotension", "C0040034#ent", "<e1>", "and", "leukopenia", "were", "induced", "by", "C0000254#ent", "<e2>", "(", "1.0", "mg", "protein/kg", "i.v", ".", ")", ","], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000254", "name": "C0000254#ent", "pos": [10, 11]}}
{"token": ["Adherence", "of", "C.", "jejuni", "to", "viable", "HeLa", "cells", "markedly", "reduced", "with", "the", "antiserum", "to", "C3889252#ent", "<e1>", ",", "whereas", "the", "CBF2", "antiserum", "was", "a", "C0003015#ent", "<e2>"], "h": {"id": "C3889252", "name": "C3889252#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [23, 24]}}
{"token": ["Some", "patients", "with", "C0014130#ent", "<e1>", "including", "two", "with", "C0221002#ent", "<e2>", "had", "slightly", "elevated", "serum", "PTHrP", "concentrations", ",", "while", "they", "were", "normal", "in", "sarcoidosis", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [8, 9]}}
{"token": ["There", "was", "a", "significant", "increase", "of", "gamma-carboxyglutamate", "(", "Gla", ")", "osteocalcin", ",", "bone", "alkaline", "phosphatase", "B-ALP", ")", ",", "C0297331#ent", "<e1>", "TRACP", ")", ",", "and", "cross-linked", "C1173296#ent", "<e2>", "NTx", ")", "levels", "after", "vitamin", "K2", "administration", "."], "h": {"id": "C0297331", "name": "C0297331#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1173296", "name": "C1173296#ent", "pos": [25, 26]}}
{"token": ["The", "urinary", "excretion", "phenol", ",", "p-cresol", ",", "and", "indican", "was", "determined", "in", "7", "patients", "with", "the", "C0005750#ent", "<e1>", "26", "patients", "with", "C0007570#ent", "<e2>", "chronic", "pancreatitis", "and", "partial", "gastrectomy", "and", "18", "control", "patients", "."], "h": {"id": "C0005750", "name": "C0005750#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [21, 22]}}
{"token": ["This", "effect", "was", "reversed", "by", "coperfusion", "of", "tetrodotoxin", ",", "and", "by", "the", "selective", "5-hydroxytryptamine2A", "receptor", "C0212182#ent", "<e1>", ",", "but", "not", "by", "the", "5-hydroxytryptamine2C", "antagonist", "C0665061#ent", "<e2>", "."], "h": {"id": "C0212182", "name": "C0212182#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0665061", "name": "C0665061#ent", "pos": [24, 25]}}
{"token": ["In", "this", "double-blind", "clinical", "trial", ",", "we", "recruited", "18", "patients", "who", "received", "topical", "treatment", "1", "alpha,25(OH)2D3", "(", "15", "microgram/g", "C0728774#ent", "<e1>", ")", "or", "placebo", "on", "separated", "C0003872#ent", "<e2>", "lesions", "for", "8", "weeks", "."], "h": {"id": "C0728774", "name": "C0728774#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [26, 27]}}
{"token": ["Two", "sequence", "elements", "upstream", "of", "DIN1", "(", "RNR3", ")", "are", "C1512488#ent", "<e1>", "to", "putative", "DNA", "damage", "regulatory", "elements", "the", "promoter", "of", "the", "reductase", "catalytic", "subunit", "gene", "C1419437#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419437", "name": "C1419437#ent", "pos": [26, 27]}}
{"token": ["In", "certain", "patients", "with", "mitral", "valve", "prolapse", "C0014863#ent", "<e1>", "be", "the", "cause", "of", "C0231218#ent", "<e2>"], "h": {"id": "C0014863", "name": "C0014863#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [13, 14]}}
{"token": ["The", "post-poliomyelitis", "syndrome", "C1456687#ent", "<e1>", ")", "refers", "to", "symptoms", "of", "new", "C3714552#ent", "<e2>", ",", "fatigue", ",", "and", "pain", "years", "recovery", "from", "acute", "poliomyelitis"], "h": {"id": "C1456687", "name": "C1456687#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [11, 12]}}
{"token": ["After", "injecting", "micro-drops", "of", "C0360097#ent", "<e1>", "in", "the", "Ipc", ",", "the", "C2986870#ent", "<e2>", "of", "the", "corresponding", "tectal", "locus", "disappeared", "completely", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986870", "name": "C2986870#ent", "pos": [11, 12]}}
{"token": ["The", "resistant", "PTC", "cell", "lines", "however", ",", "showed", "a", "graded", "loss", "of", "C1705964#ent", "<e1>", "receptor-mediated", "antiproliferation", "and", "a", "concomitant", "activation", "of", "a", "C1363982#ent", "<e2>", "receptor-mediated", "growth", "stimulation", "."], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1363982", "name": "C1363982#ent", "pos": [22, 23]}}
{"token": ["The", "authors", "identified", "an", "isoform", "of", "C0086669#ent", "<e1>", "approximately", "110", "-", "125", "KDa", ",", "homologous", "to", "C0027102#ent", "<e2>", "Acanthamoeba", ",", "a", "fraction", "of", "which", "colocalized", "with", "the", "peripheral", "actin", "ring"], "h": {"id": "C0086669", "name": "C0086669#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027102", "name": "C0027102#ent", "pos": [16, 17]}}
{"token": ["Previous", "work", "has", "shown", "that", "this", "C0079429#ent", "<e1>", "lies", "adjacent", "to", "the", "gene", "coding", "RNase", "H", "C3539762#ent", "<e2>", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539762", "name": "C3539762#ent", "pos": [16, 17]}}
{"token": ["Identification", "of", "a", "previously", "unknown", "family", "of", "membrane", "proteins", "associated", "with", "C3811086#ent", "<e1>", "improve", "our", "understanding", "of", "C3811086#ent", "<e1>", "physiopathology", "and", "allow", "for", "the", "development", "of", "pharmacological", "tools", "for", "basic", "research", "and", "drug", "development"], "h": {"id": "C3811086", "name": "C3811086#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3811086", "name": "C3811086#ent", "pos": [11, 12]}}
{"token": ["C3811086#ent", "<e1>", "ClC", ")", "are", "found", "in", "living", "systems", "they", "C3811086#ent", "<e1>", "across", "cell", "membranes"], "h": {"id": "C3811086", "name": "C3811086#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3811086", "name": "C3811086#ent", "pos": [0, 1]}}
{"token": ["MTFK", "exhibited", "FK506", "sensitive", "C0136073#ent", "<e1>", "(", "peptidyl", "prolyl", "cis-trans", "isomerase", "activity", "which", "accelerated", "the", "speed", "of", "C0018364#ent", "<e2>", "which", "is", "rate-limited", "by", "isomerization", "of", "two", "prolyl", "peptide", "bonds", "."], "h": {"id": "C0136073", "name": "C0136073#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018364", "name": "C0018364#ent", "pos": [17, 18]}}
{"token": ["Preliminary", "data", "that", "C0218640#ent", "<e1>", "is", "effective", "in", "increasing", "the", "neutrophil", "count", "patients", "with", "severe", "C0027947#ent", "<e2>", "Kostmann's", "syndrome", ",", "as", "well", "as", "patients", "with", "AIDS", "or", "AIDS-related", "complex", "zidovudine-induced", "neutropenia", "."], "h": {"id": "C0218640", "name": "C0218640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [15, 16]}}
{"token": ["Cellular", "uptake", "C0296299#ent", "<e1>", "is", "proportionally", "decreased", "in", "the", "presence", "of", "alpha", "1", "C4283942#ent", "<e2>", ",", "which", "results", "in", "less-than-expected", "antiviral", "activity"], "h": {"id": "C0296299", "name": "C0296299#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283942", "name": "C4283942#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "how", "often", "the", "second", "lumbrical", "motor", "potential", "is", "present", "when", "the", "abductor", "pollicis", "brevis", "C1868120#ent", "<e1>", ")", "motor", "potential", "absent", "in", "severe", "C0007286#ent", "<e2>", "CTS", ")", "."], "h": {"id": "C1868120", "name": "C1868120#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [24, 25]}}
{"token": ["To", "determine", "how", "often", "the", "second", "lumbrical", "motor", "potential", "is", "present", "when", "the", "abductor", "pollicis", "brevis", "C1868120#ent", "<e1>", ")", "motor", "potential", "absent", "in", "severe", "carpal", "tunnel", "syndrome", "C0007286#ent", "<e2>", ")", "."], "h": {"id": "C1868120", "name": "C1868120#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [27, 28]}}
{"token": ["Single", "nucleotide", "polymorphisms", "the", "CYP2C9", "gene", "in", "the", "expression", "of", "three", "important", "variants", ",", "CYP2C9", "*", "1(wild-type", ")", ",", "CYP2C9*2", "C1707205#ent", "<e1>", "the", "last", "two", "exhibiting", "reduced", "catalytic", "activity", "with", "the", "C2987364#ent", "<e2>", "."], "h": {"id": "C1707205", "name": "C1707205#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [31, 32]}}
{"token": ["At", "concentrations", "of", "between", "4", "and", "32", "micrograms/ml", ",", "AZM", "also", "inhibited", "C0030946#ent", "<e1>", "elastase", ",", "and", "C0031669#ent", "<e2>", "production", "by", "P.", "aeruginosa", "more", "than", "did", "EM", ",", "RXM", ",", "and", "RKM", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [17, 18]}}
{"token": ["To", "compare", "HLA-C", "genotypes", "smoking", "habits", "patients", "with", "vasculitis", "or", "other", "severe", "extraarticular", "manifestations", "of", "rheumatoid", "arthritis", "ExRA", ")", "with", "those", "in", "C0003873#ent", "<e1>", "patients", "without", "C0022408#ent", "<e2>"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [26, 27]}}
{"token": ["The", "authors", "recommend", "that", "patients", "taking", "C0008402#ent", "<e1>", "who", "have", "concomitant", "C1565489#ent", "<e2>", "who", "are", "volume", "depleted", "or", "who", "are", "taking", "spironolactone", "be", "monitored", "carefully", "for", "the", "emergence", "of", "a", "hyperchloremic", "metabolic", "acidosis"], "h": {"id": "C0008402", "name": "C0008402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [11, 12]}}
{"token": ["Increases", "in", "C0917785#ent", "<e1>", "activity", ",", "along", "with", "inhibition", "of", "glycogen", "synthetase", "C0162449#ent", "<e2>", ",", "are", "associated", "with", "elevated", "cryoprotectant", "(", "glucose", ")", "levels", "during", "freezing", "in", "some", "freeze-tolerant", "anurans", "."], "h": {"id": "C0917785", "name": "C0917785#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162449", "name": "C0162449#ent", "pos": [12, 13]}}
{"token": ["The", "results", "suggest", "that", "IFN-gamma", "C1417679#ent", "<e1>", "play", "an", "important", "role", "in", "chicken", "primary", "secondary", "antibody", "to", "C1705087#ent", "<e2>", "and", "BA", "antigens", "and", "there", "exists", "interaction", "among", "C1417679#ent", "<e1>", "for", "antibody", "production", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705087", "name": "C1705087#ent", "pos": [17, 18]}}
{"token": ["ii", ")", "After", "C0025007#ent", "<e1>", "and", "other", "C0162628#ent", "<e2>", "or", "incubation", "with", "dsRNA", ",", "DCs", "become", "cytotoxic", "and", "consequently", "exhibit", "natural", "killer", "function", "through", "upregulation", "of", "type", "I", "IFN", "secretion", "which", "enhances", "TRAIL", "expression", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [7, 8]}}
{"token": ["A", "modified", "version", "of", "the", "C0020616#ent", "<e1>", "Fear", "Survey", "(", "C0019104#ent", "<e2>", ")", "was", "used", "to", "measure", "fear", "of", "hypoglycemia", "among", "mothers", "of", "46", "pre-adolescent", "children", "with", "IDDM", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019104", "name": "C0019104#ent", "pos": [10, 11]}}
{"token": ["C0017337#ent", "<e1>", "downstream", "of", "C1334100#ent", "<e2>", "may", "provide", "targets", "for", "the", "treatment", "of", "implantation", "failure", "the", "development", "of", "non-hormonal", "contraceptives"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334100", "name": "C1334100#ent", "pos": [4, 5]}}
{"token": ["These", "changes", "could", "partially", "account", "for", "the", "charge", "specificity", "synaptic", "transmission", "well", "as", "for", "the", "fast", "signaling", "the", "C0001477#ent", "<e1>", "and", "the", "fusion", "apparatus", "channel-associated-vesicles", "(", "C1332670#ent", "<e2>", ")", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1332670", "name": "C1332670#ent", "pos": [26, 27]}}
{"token": ["Its", "most", "prominent", "clinical", "features", "were", "C0026821#ent", "<e1>", "chronic", "musculoskeletal", "pain", "chronic", "lung", "disease", "Raynaud", "phenomenon", ",", "C0007286#ent", "<e2>", "and", "psychologic", "disturbances"], "h": {"id": "C0026821", "name": "C0026821#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [17, 18]}}
{"token": ["A", "second", "set", "of", "baseline", "measurements", "was", "obtained", "and", "the", "sheep", "then", "received", "the", "combined", "cyclooxygenase/lipoxygenase", "inhibitor", "C0006536#ent", "<e1>", ",", "the", "selective", "C1289971#ent", "<e2>", ",", "or", "the", "leukotriene", "receptor", "antagonist", "LY171883", "."], "h": {"id": "C0006536", "name": "C0006536#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1289971", "name": "C1289971#ent", "pos": [22, 23]}}
{"token": ["The", "enzyme", "was", "not", "inhibited", "by", "L-(+)-tartrate", ",", "and", "was", "significantly", "activated", "by", "C1417699#ent", "<e1>", "+", "and", "reducing", "C0991617#ent", "<e2>", "such", "as", "ascorbic", "acid", "L-cysteine", ",", "and", "dithiothreitol", "."], "h": {"id": "C1417699", "name": "C1417699#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [18, 19]}}
{"token": ["To", "characterize", "the", "molecular", "lesion(s", ")", "causing", "C0026709#ent", "<e1>", "rats", ",", "cDNAs", "encoding", "rat", "C1615657#ent", "<e2>", "were", "isolated", "from", "a", "rat", "liver", "cDNA", "library", "."], "h": {"id": "C0026709", "name": "C0026709#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C1615657", "name": "C1615657#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "yohimbine", "and", "C0013084#ent", "<e1>", "on", "xylazine-induced", "prolongation", "of", "C0030920#ent", "<e2>", "barium", "sulfate", "studied", "in", "5", "dogs", "."], "h": {"id": "C0013084", "name": "C0013084#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [11, 12]}}
{"token": ["Results", "prove", "that", "Nox2", "and", "C3273503#ent", "<e1>", "are", "the", "C1332838#ent", "<e2>", "and", "that", "phosphorylation", "processes", "are", "important", "in", "the", "regulation", "of", "glucose", "uptake", "which", "cancer", "cells", "."], "h": {"id": "C3273503", "name": "C3273503#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332838", "name": "C1332838#ent", "pos": [9, 10]}}
{"token": ["C0537894#ent", "<e1>", "or", "micafungin", "might", "be", "preferred", "to", "anidulafungin", "in", "the", "C0023530#ent", "<e2>", "patient", "."], "h": {"id": "C0537894", "name": "C0537894#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [11, 12]}}
{"token": ["These", "results", "show", "that", "although", "both", "stimuli", "lead", "to", "C0072523#ent", "<e1>", "gene", "activation", "estradiol", "and", "TPA", "exert", "their", "effects", "on", "C1366563#ent", "<e2>", "expression", "by", "different", "mechanisms", "."], "h": {"id": "C0072523", "name": "C0072523#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366563", "name": "C1366563#ent", "pos": [20, 21]}}
{"token": ["Three", "C0072523#ent", "<e1>", "known", "in", "mammals", ":", "C1366563#ent", "<e2>", ",", "TFF2", ",", "and", "TFF3", "."], "h": {"id": "C0072523", "name": "C0072523#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366563", "name": "C1366563#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "C0073561#ent", "<e1>", "is", "a", "C0013227#ent", "<e2>", "that", "causes", "the", "EEG", "arousal", "pattern", "."], "h": {"id": "C0073561", "name": "C0073561#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}}
{"token": ["Seven", "patients", "from", "6", "families", "with", "C1707070#ent", "<e1>", "in", "which", "C1631597#ent", "<e2>", "polymorphic", "VT", "induced", "by", "exercise", "or", "isoproterenol", "infusion", "visited", "our", "hospitals", "."], "h": {"id": "C1707070", "name": "C1707070#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1631597", "name": "C1631597#ent", "pos": [10, 11]}}
{"token": ["Tyr-568", "has", "previously", "been", "identified", "as", "the", "binding", "site", "the", "Src", "family", "tyrosine", "kinases", "the", "Csk-homologous", "kinase", "C0250935#ent", "<e1>", ",", "and", "the", "C0085536#ent", "<e2>", "SHP-2", "."], "h": {"id": "C0250935", "name": "C0250935#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [22, 23]}}
{"token": ["Preoperative", "hydration", "and", "C3536863#ent", "<e1>", "balance", "and", "selection", "of", "C0002932#ent", "<e2>", "were", "easily", "titrated", "was", "associated", "with", "smooth", "intraoperative", "course", "on", "this", "patient", "."], "h": {"id": "C3536863", "name": "C3536863#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002932", "name": "C0002932#ent", "pos": [9, 10]}}
{"token": ["NFIB", "protein", "binds", "the", "C3273860#ent", "<e1>", "promoter", "in", "HL-60", "cells", "a", "negative", "regulator", "and", "is", "swept", "off", "from", "the", "C3273860#ent", "<e1>", "promoter", "during", "C1321914#ent", "<e1>", "macrophage", "differentiation", "of", "HL-60", "."], "h": {"id": "C3273860", "name": "C3273860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [23, 24]}}
{"token": ["Recently", ",", "a", "short-course", "treatment", "using", "60", "daily", "doses", "rifampin", "and", "C0034239#ent", "<e1>", "was", "recommended", "for", "C1609538#ent", "<e2>", "TB", ")", "infection", "(", "LTBI", ")", "."], "h": {"id": "C0034239", "name": "C0034239#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1609538", "name": "C1609538#ent", "pos": [16, 17]}}
{"token": ["More", "speculative", "new", "drugs", "for", "IBS", "include", "C1413167#ent", "<e1>", "as", "loxiglumide", "and", "the", "C1518041#ent", "<e2>", "leuprorelin", "(", "leuprolide", ")", "."], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1518041", "name": "C1518041#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "the", "first", "patient", ",", "to", "our", "knowledge", ",", "to", "receive", "a", "diagnosis", "of", "C0151332#ent", "<e1>", "concurrent", ",", "severe", "neurological", "Eales", "disease", "including", "C0235025#ent", "<e2>"], "h": {"id": "C0151332", "name": "C0151332#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [24, 25]}}
{"token": ["(", "1", ")", "C0268543#ent", "<e1>", "a", "rare", "congenital", "disorder", "causes", "C0220994#ent", "<e2>", "resulting", "in", "severe", "neurological", "morbidity", "usually", "leading", "to", "death", "during", "childhood", "."], "h": {"id": "C0268543", "name": "C0268543#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0220994", "name": "C0220994#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "if", "combined", "intraocular", "pressure", "medication", "with", "travoprost/timolol", "fixed", "combination", "and", "a", "carbonic", "anhydrase", "inhibitor", "brinzolamide", ",", "is", "superior", "to", "both", "C0937916#ent", "<e1>", "monotherapy", "and", "travoprost/timolol", "fixed-combination", "therapy", "in", "C0017612#ent", "<e2>", "ocular", "hypertension"], "h": {"id": "C0937916", "name": "C0937916#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [30, 31]}}
{"token": ["When", "C0036572#ent", "<e1>", "were", "preceded", "by", "antihypertensive", "treatment", "the", "C3536752#ent", "<e2>", "phentolamine", ",", "peak", "blood", "pressure", "to", "remain", "near", "the", "baseline", "level", "and", "lower", "than", "sham-injected", "controls", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536752", "name": "C3536752#ent", "pos": [9, 10]}}
{"token": ["TFF-peptides", "(", "i.e.", "C1366563#ent", "<e1>", ",", "TFF2", ",", "TFF3", ";", "formerly", "P-domain", "peptides", ",", "C0072523#ent", "<e2>", "have", "been", "established", "as", "secretory", "products", "of", "the", "gastrointestinal", "tract"], "h": {"id": "C1366563", "name": "C1366563#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0072523", "name": "C0072523#ent", "pos": [14, 15]}}
{"token": ["C1366563#ent", "<e1>", "had", "no", "effect", "estrogenic", "markers", "serum", "and", "no", "effect", "C0072523#ent", "<e2>", "or", "cellular", "morphology", "nipple", "aspirate", "fluid"], "h": {"id": "C1366563", "name": "C1366563#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0072523", "name": "C0072523#ent", "pos": [11, 12]}}
{"token": ["Drosophila", "Mi-2", "dMi-2", ")", "is", "the", "C1412687#ent", "<e1>", "a", "complex", "combining", "C0059946#ent", "<e2>", "nucleosome", "remodelling", "and", "histone", "deacetylase", "activities", "."], "h": {"id": "C1412687", "name": "C1412687#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [11, 12]}}
{"token": ["This", "finding", "raises", "important", "questions", "about", "the", "cellular", "location", "and", "function", "of", "C0030238#ent", "<e1>", "mutations", "in", "which", "result", "in", "the", "neurodegenerative", "disorder", "C0022340#ent", "<e2>"], "h": {"id": "C0030238", "name": "C0030238#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022340", "name": "C0022340#ent", "pos": [22, 23]}}
{"token": ["Twenty-two", "cats", "had", "C1561643#ent", "<e1>", "1", "cat", "had", "C1408247#ent", "<e2>", "associated", "with", "glycol-induced", "toxicosis", "."], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1408247", "name": "C1408247#ent", "pos": [8, 9]}}
{"token": ["The", "activities", "of", "C1413745#ent", "<e1>", "malate", "synthase", "malate", "dehydrogenase", "detected", "in", "the", "peroxisomal", "fraction", "also", "increased", "by", "C0030086#ent", "<e2>", "treatment", "."], "h": {"id": "C1413745", "name": "C1413745#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030086", "name": "C0030086#ent", "pos": [17, 18]}}
{"token": ["Altogether", ",", "these", "findings", "indicate", "that", "C3272754#ent", "<e1>", "functions", "as", "a", "C0031727#ent", "<e2>", "Stat1", "and", "an", "upstream", "regulator", "the", "p38", "MAP", "kinase", "plays", "an", "important", "role", "in", "the", "induction", "of", "Type", "I", "responses", "."], "h": {"id": "C3272754", "name": "C3272754#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["Levels", "of", "hemoglobin", "Alc", "HbAlc", ")", "and", "fructosamine", "(", "C1538772#ent", "<e1>", ")", "were", "not", "correlated", "with", "levels", "of", "Vit", "D", "C3539565#ent", "<e2>", "."], "h": {"id": "C1538772", "name": "C1538772#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539565", "name": "C3539565#ent", "pos": [20, 21]}}
{"token": ["Src", "family", "kinases", "phosphorylate", "ITAMs", "on", "dual", "tyrosines", "which", "enable", "recruitment", "and", "activation", "of", "C1337056#ent", "<e1>", "binding", "to", "dual", "SH2", "domains", "these", "C0031727#ent", "<e2>", "."], "h": {"id": "C1337056", "name": "C1337056#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [22, 23]}}
{"token": ["MAP", "kinase-activated", "protein", "C1442514#ent", "<e1>", ")", "kinase-2", "is", "activated", "in", "vivo", "reactivating", "kinase", "(", "C1384522#ent", "<e2>", ")", ",", "a", "MAP", "kinase", "MAPK", ")", "homologue", "stimulated", "by", "cytokines", "and", "cellular", "stresses"], "h": {"id": "C1442514", "name": "C1442514#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1384522", "name": "C1384522#ent", "pos": [14, 15]}}
{"token": ["These", "results", "establish", "that", "C1442514#ent", "<e1>", "kinase-2", "is", "a", "physiological", "C1384522#ent", "<e2>", "substrate", ",", "and", "that", "HSP27", "is", "phosphorylated", "by", "C1442514#ent", "<e1>", "kinase-2", "in", "vivo"], "h": {"id": "C1442514", "name": "C1442514#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1384522", "name": "C1384522#ent", "pos": [10, 11]}}
{"token": ["There", "are", "sometimes", "observed", "in", "genetically", "transmitted", "C0009782#ent", "<e1>", "which", "numerous", "systemic", "complications", "are", "associated", "as", "C0013720#ent", "<e2>", "and", "in", "Gr\u00f6nblad-Strandberg", "syndromes"], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0013720", "name": "C0013720#ent", "pos": [16, 17]}}
{"token": ["Exogenously", "added", "C1522405#ent", "<e1>", "reversed", "the", "suppressive", "activity", "of", "C0751039#ent", "<e2>", ",", "but", "not", "that", "of", "PDG", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [9, 10]}}
{"token": ["PDG", "inhibited", "only", "IL-2Ralpha", "expression", ",", "but", "not", "C1522405#ent", "<e1>", "expression", ",", "whereas", "C0751039#ent", "<e2>", "inhibited", "both", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [13, 14]}}
{"token": ["No", "correlation", "was", "found", "between", "changes", "in", "the", "serum", "lipid", "concentrations", "changes", "in", "hsCRP", ",", "C1337092#ent", "<e1>", ",", "PAI-1", ",", "or", "fibrinogen", "in", "either", "the", "C2698196#ent", "<e2>", "or", "the", "no-drug", "group", "."], "h": {"id": "C1337092", "name": "C1337092#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2698196", "name": "C2698196#ent", "pos": [25, 26]}}
{"token": ["The", "concentrations", "of", "the", "cytokines", "interleukin-1beta", ",", "interleukin-6", "and", "tumor", "necrosis", "factor-alpha", "the", "chemokines", "CCL5", "and", "C1337092#ent", "<e1>", "were", "significantly", "decreased", "in", "arthritic", "rats", "treated", "with", "C2698196#ent", "<e2>", "."], "h": {"id": "C1337092", "name": "C1337092#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2698196", "name": "C2698196#ent", "pos": [26, 27]}}
{"token": ["Moreover", ",", "we", "found", "that", "LPS-induced", "IKK", "beta", "activity", "an", "C0014442#ent", "<e1>", "responsible", "for", "phosphorylation", "of", "I", "kappa", "B", "alpha", "was", "inhibited", "upon", "C0084370#ent", "<e2>", "activation", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0084370", "name": "C0084370#ent", "pos": [23, 24]}}
{"token": ["The", "urinary", "clearance", "of", "C0034261#ent", "<e1>", "was", "studied", "in", "six", "patients", "with", "C0026896#ent", "<e2>"], "h": {"id": "C0034261", "name": "C0034261#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [12, 13]}}
{"token": ["C0618743#ent", "<e1>", "one", "of", "the", "C0076726#ent", "<e2>", "and", "the", "distal", "nephron", "fully", "equipped", "as", "an", "element", "of", "the", "kallikrein-kinin", "system"], "h": {"id": "C0618743", "name": "C0618743#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0076726", "name": "C0076726#ent", "pos": [5, 6]}}
{"token": ["The", "nucleic", "acid", "sequence", "the", "C0618743#ent", "<e1>", "cDNA", "is", "identical", "to", "that", "of", "renal/pancreatic", "or", "C0076726#ent", "<e2>", "cDNA", "."], "h": {"id": "C0618743", "name": "C0618743#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0076726", "name": "C0076726#ent", "pos": [15, 16]}}
{"token": ["Low-density", "lipoprotein", "receptor-related", "protein", "LRP", ")", "is", "an", "C3537377#ent", "<e1>", "binds", "multiple", "distinct", "ligands", ",", "including", "blood", "coagulation", "factor", "VIII", "C2732002#ent", "<e2>", ")", "."], "h": {"id": "C3537377", "name": "C3537377#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2732002", "name": "C2732002#ent", "pos": [20, 21]}}
{"token": ["C0001645#ent", "<e1>", ",", "such", "as", "phenoxybenzamine", ",", "dibenamine", ",", "and", "C0014710#ent", "<e2>", "and", "beta-blockers", ",", "such", "as", "butoxamine", ",", "timolol", ",", "and", "practolol", ",", "were", "ineffective", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014710", "name": "C0014710#ent", "pos": [10, 11]}}
{"token": ["This", "study", "describes", "the", "C1836830#ent", "<e1>", "three", "neurotrophins", ",", "brain", "derived", "C1522444#ent", "<e2>", "BDNF", ")", ",", "neurotrophin", "3", "NT-3", ")", "and", "neurotrophin", "(", "NT-4", ")", "in", "the", "rat", "auditory", "brain-stem", "using", "immunohistochemistry", "."], "h": {"id": "C1836830", "name": "C1836830#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522444", "name": "C1522444#ent", "pos": [11, 12]}}
{"token": ["As", "both", "retinoids", "and", "C0017347#ent", "<e1>", "been", "implicated", "in", "lung", "development", "patterning", ",", "we", "have", "examined", "C1415658#ent", "<e2>", "expression", "in", "the", "developing", "mouse", "lung", "and", "extended", "our", "work", "on", "its", "regulation", "."], "h": {"id": "C0017347", "name": "C0017347#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415658", "name": "C1415658#ent", "pos": [16, 17]}}
{"token": ["C0149939#ent", "<e1>", "a", "primary", "cause", "of", "C0035078#ent", "<e2>", "infants", "and", "children", "."], "h": {"id": "C0149939", "name": "C0149939#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [6, 7]}}
{"token": ["The", "intracellular", "pH", "of", "a", "normal", "lens", "6.8", "in", "the", "C0001614#ent", "<e1>", "and", "remains", "unchanged", "during", "culture", "in", "C1553427#ent", "<e2>", "pH", "7.2", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1553427", "name": "C1553427#ent", "pos": [18, 19]}}
{"token": ["To", "date", ",", "the", "majority", "of", "individuals", "with", "C0694883#ent", "<e1>", "have", "been", "found", "to", "have", "genetic", "alterations", "C1431123#ent", "<e2>", ",", "most", "of", "which", "result", "in", "protein", "truncation"], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1431123", "name": "C1431123#ent", "pos": [17, 18]}}
{"token": ["Two", "of", "the", "mothers", "had", "C1510471#ent", "<e1>", "and", "one", "of", "them", "also", "had", "C0042847#ent", "<e2>"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0042847", "name": "C0042847#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "whether", "PAX1", "haploinsufficiency", "plays", "a", "role", "in", "C1415036#ent", "<e1>", ",", "we", "have", "defined", "the", "gene", "structure", "the", "human", "PAX1", "gene", "screened", "63", "C1415036#ent", "<e1>", "patients", "for", "mutations", "in", "this", "C0017337#ent", "<e1>", "."], "h": {"id": "C1415036", "name": "C1415036#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [31, 32]}}
{"token": ["Two", "siblings", "and", "a", "third", "child", "exhibited", "a", "syndrome", "of", "progressive", "muscular", "weakness", "C0235394#ent", "<e1>", ",", "closely", "resembling", "C0043116#ent", "<e2>"], "h": {"id": "C0235394", "name": "C0235394#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0043116", "name": "C0043116#ent", "pos": [18, 19]}}
{"token": ["Such", "inhibition", "was", "partly", "due", "to", "IL-10", "and", "C1515406#ent", "<e1>", ",", "but", "cognate", "interactions", "with", "either", "C0033036#ent", "<e2>", "or", "Th1", "cells", "also", "involved", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [16, 17]}}
{"token": ["The", "patient", ",", "who", "was", "being", "treated", "with", "digitoxin", "for", "C0018801#ent", "<e1>", "reported", "having", "taken", "up", "to", "four", "C0012258#ent", "<e2>", "0.07", "mg", "each", ")", "daily", "because", "she", "had", "insomnia", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0012258", "name": "C0012258#ent", "pos": [18, 19]}}
{"token": ["Several", "cellular", "proteins", "a", "major", "90-kDa", "molecular", "chaperone", "C3273507#ent", "<e1>", "were", "found", "associated", "with", "C1366622#ent", "<e2>", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366622", "name": "C1366622#ent", "pos": [14, 15]}}
{"token": ["Repetitive", "inoculation", "with", "increasing", "doses", "of", "LPS", "induced", "C0042384#ent", "<e1>", "meningoencephalitis", "and", "C0032310#ent", "<e2>", ",", "while", "hemorrhage", "was", "minimal", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032310", "name": "C0032310#ent", "pos": [12, 13]}}
{"token": ["C1839163#ent", "<e1>", "was", "associated", "with", "increase", "in", "the", "incidence", "of", "antibodies", "to", "C1704693#ent", "<e2>", "and", "GPIb", ",", "whereas", "the", "antigen", "most", "frequently", "recognized", "in", "patients", "without", "thrombocytopenia", "was", "GPIIb", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704693", "name": "C1704693#ent", "pos": [12, 13]}}
{"token": ["Mouse", "CD1", "C3889998#ent", "<e1>", ")", "is", "an", "antigen-presenting", "molecule", "is", "C0907533#ent", "<e2>", "expressed", "by", "most", "bone", "marrow-derived", "cells"], "h": {"id": "C3889998", "name": "C3889998#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}}
{"token": ["It", "is", "well", "known", "that", "both", "active", "immunization", "C0009450#ent", "<e1>", "induce", "the", "C0027726#ent", "<e2>"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [12, 13]}}
{"token": ["Control", "or", "eradication", "of", "C0009450#ent", "<e1>", "lower", "the", "incidence", "of", "childhood", "C0027726#ent", "<e2>", "Africa", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [11, 12]}}
{"token": ["The", "suppressive", "effects", "of", "C3539739#ent", "<e1>", ",", "NP", "and", "OP", ",", "but", "not", "PCP", "or", "C3540506#ent", "<e2>", ",", "were", "blocked", "by", "the", "estrogen", "receptor", "ER", ")", "inhibitor", ",", "ICI182780", "."], "h": {"id": "C3539739", "name": "C3539739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540506", "name": "C3540506#ent", "pos": [15, 16]}}
{"token": ["The", "CTTT", "at", "F439", "in", "C0041484#ent", "<e1>", "is", "also", "present", "at", "F508", "in", "C1413365#ent", "<e2>", ",", "the", "main", "mutation", "causing", "cystic", "fibrosis"], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413365", "name": "C1413365#ent", "pos": [13, 14]}}
{"token": ["We", "present", "structural", "and", "C0058836#ent", "<e1>", "evidence", "for", "allosteric", "effects", "a", "PDZ", "domain", "PDZ2", "from", "the", "tyrosine", "phosphatase", "C3538801#ent", "<e2>", ",", "upon", "binding", "to", "a", "target", "peptide", "."], "h": {"id": "C0058836", "name": "C0058836#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538801", "name": "C3538801#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "the", "upregulation", "of", "MMP-13", "mRNA", "by", "androgen", "could", "be", "abolished", "by", "the", "androgen", "antagonist", "C0591237#ent", "<e1>", "but", "not", "the", "C1418370#ent", "<e2>", "cycloheximide", "."], "h": {"id": "C0591237", "name": "C0591237#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418370", "name": "C1418370#ent", "pos": [22, 23]}}
{"token": ["We", "found", ",", "PCSK2", ",", "C1540053#ent", "<e1>", ",", "RAP1", "GA1", "to", "be", "specifically", "overexpressed", "in", "follicular", "cancer", "C1419786#ent", "<e2>", "and", "GK2", "in", "papillary", "carcinoma"], "h": {"id": "C1540053", "name": "C1540053#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419786", "name": "C1419786#ent", "pos": [17, 18]}}
{"token": ["C1413396#ent", "<e1>", "is", "a", "GTPase-activating", "protein", "C1419277#ent", "<e2>", ")", "mainly", "for", "Rac1", "and", "less", "so", "for", "Cdc42Hs", "in", "vitro"], "h": {"id": "C1413396", "name": "C1413396#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419277", "name": "C1419277#ent", "pos": [6, 7]}}
{"token": ["Colon", "motility", "man", "ist", "actively", "affected", "by", "adrenergic", "drugs", "it", "is", "inhibited", "by", "C0001648#ent", "<e1>", "and", "stimulated", "by", "C0242889#ent", "<e2>", "which", "justifies", "their", "prescription", "in", "colon", "dyskinesia", "."], "h": {"id": "C0001648", "name": "C0001648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [18, 19]}}
{"token": ["C0221014#ent", "<e1>", "to", "bronchiectasis", "and", "recurrent", "C0876973#ent", "<e2>", "identified", "in", "40", "%", "(", "16", "patients", ")", "of", "the", "40", "patients", "."], "h": {"id": "C0221014", "name": "C0221014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0876973", "name": "C0876973#ent", "pos": [6, 7]}}
{"token": ["Thirty-nine", "patients", "with", "a", "variety", "of", "diseases", ",", "including", "essential", "tremor", "Parkinson's", "Disease", "olivopontocerebellar", "degeneration", "C3711796#ent", "<e1>", "and", "cervical", "cord", "injury", "with", "C0234376#ent", "<e2>", "were", "evaluated", "for", "the", "effect", "of", "one", "ounce", "of", "absolute", "alcohol", "ingestion"], "h": {"id": "C3711796", "name": "C3711796#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0234376", "name": "C0234376#ent", "pos": [22, 23]}}
{"token": ["We", "have", "recently", "demonstrated", "that", "thrombin-induced", "actin", "reorganization", "in", "bovine", "pulmonary", "artery", "endothelial", "cells", "(", "BPAEC", ")", "requires", "activation", "of", "both", "C0027120#ent", "<e1>", "MLCK", ")", "and", "C1259877#ent", "<e2>", "PKC", ")", "."], "h": {"id": "C0027120", "name": "C0027120#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [26, 27]}}
{"token": ["Once", "the", "cellular", "contact", "stopped", ",", "captured", "C0019693#ent", "<e1>", "were", "released", "as", "C0009450#ent", "<e2>"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [12, 13]}}
{"token": ["The", "results", "obtained", "in", "C0019693#ent", "<e1>", "patients", "may", "be", "extrapolated", "to", "other", "C0009450#ent", "<e2>", "in", "the", "absence", "of", "available", "data", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "the", "inhibitory", "effects", "of", "neopterin", "(", "C1824810#ent", "<e1>", ")", "and", "its", "reduced", "form", ",", "5,6,7,8-tetrahydroneopterin", "(", "C1417905#ent", "<e2>", ")", ",", "on", "carbon", "tetrachloride", "hepatotoxicity", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417905", "name": "C1417905#ent", "pos": [18, 19]}}
{"token": ["Out", "of", "97", "C2239659#ent", "<e1>", "expressed", "in", "two", "ESC", "lines", ",", "72", "C0086376#ent", "<e2>", "were", "identified", "using", "MALDI", "TOF-TOF", "mass", "spectrometry", "analysis"], "h": {"id": "C2239659", "name": "C2239659#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["Therefore", ",", "in", "this", "study", "the", "effects", "of", "used", "antibiotics", ",", "namely", "sodium", "ampicillin", "C0008809#ent", "<e1>", ",", "rifamycin", "SV", "clindamycin", "phosphate", "on", "human", "C1418754#ent", "<e2>", "were", "investigated", "in", "vitro", "in", "vivo"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418754", "name": "C1418754#ent", "pos": [23, 24]}}
{"token": ["These", "findings", "suggest", "that", "postinfarct", "remodeling", "disrupts", "cellular", "signaling", "the", "EPO", "receptor", "C1709402#ent", "<e1>", "presumably", "by", "increased", "C1426208#ent", "<e2>", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1426208", "name": "C1426208#ent", "pos": [17, 18]}}
{"token": ["Particular", "interest", "in", "this", "gene", "family", "stimulated", "by", "the", "fact", "that", "the", "SLC26A2", ",", "C1335836#ent", "<e1>", ",", "and", "SLC26A4", "genes", "been", "recognized", "as", "the", "C0005940#ent", "<e2>", "mutated", "in", "diastrophic", "dysplasia", "congenital", "chloride", "diarrhea", "and", "Pendred", "syndrome", "respectively", "."], "h": {"id": "C1335836", "name": "C1335836#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [24, 25]}}
{"token": ["Dilated", "cardiomyopathy", "DCM", ")", "is", "a", "C0878544#ent", "<e1>", "by", "ventricular", "dilatation", "impaired", "heart", "contraction", "is", "heterogeneous", "both", "clinically", "and", "C1516876#ent", "<e2>", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [19, 20]}}
{"token": ["Prolonged", "treatments", "of", "C0003645#ent", "<e1>", ",", "MAL", "and", "Vit", "E", "ablated", "histopathological", "evidence", "of", "C0878544#ent", "<e2>"], "h": {"id": "C0003645", "name": "C0003645#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0878544", "name": "C0878544#ent", "pos": [14, 15]}}
{"token": ["Evidence", "has", "indicated", "that", "plasma", "C1825346#ent", "<e1>", "was", "elevated", "in", "C0264716#ent", "<e2>", "CHF", ")", "patients", "with", "cachexia", "."], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0264716", "name": "C0264716#ent", "pos": [10, 11]}}
{"token": ["In", "the", "course", "of", "chronic", "inflammatory", "C0029408#ent", "<e1>", "proteoglycans", "are", "degraded", "by", "the", "action", "of", "C1947941#ent", "<e2>", "and", "oxygen", "radicals"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [15, 16]}}
{"token": ["TRPM2", "and", "C1425206#ent", "<e1>", ",", "closely", "related", "members", "of", "the", "C1421171#ent", "<e2>", "TRP", ")", "family", ",", "are", "cation", "channels", "activated", "by", "quite", "different", "mechanisms", "."], "h": {"id": "C1425206", "name": "C1425206#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421171", "name": "C1421171#ent", "pos": [10, 11]}}
{"token": ["As", "regards", "the", "production", "of", "IFN-gamma-inducing", "cytokines", ",", "IL-12", "and", "C1415900#ent", "<e1>", ",", "was", "seen", "almost", "exclusively", "from", "infected", "C0024440#ent", "<e2>", ",", "while", "IL-18", "was", "secreted", "preferentially", "by", "macrophages", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024440", "name": "C0024440#ent", "pos": [19, 20]}}
{"token": ["At", "nanomolar", "concentrations", ",", "bacterially", "produced", "mCTRP2", "rapidly", "induced", "phosphorylation", "of", "AMP-activated", "protein", "kinase", "acetyl-CoA", "carboxylase", "and", "C0752312#ent", "<e1>", "C2C12", "myotubes", ",", "which", "resulted", "in", "increased", "C0002245#ent", "<e2>", "accumulation", "and", "fatty", "acid", "oxidation"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [26, 27]}}
{"token": ["Dyschromatopsia", "is", "a", "prominent", "sign", "in", "a", "variety", "of", "C0751951#ent", "<e1>", "such", "as", "C0730328#ent", "<e2>", "CSC", ")", "."], "h": {"id": "C0751951", "name": "C0751951#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0730328", "name": "C0730328#ent", "pos": [13, 14]}}
{"token": ["The", "C4284028#ent", "<e1>", "myriocin", "potently", "suppresses", "the", "development", "of", "C0004153#ent", "<e2>", "in", "apolipoprotein", "E", "apoE", ")", "gene", "knockout", "(", "apoE(-/-", ")", ")", "mice", "fed", "a", "high-fat", "diet"], "h": {"id": "C4284028", "name": "C4284028#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [9, 10]}}
{"token": ["This", "C1416596#ent", "<e1>", "was", "used", "to", "assess", "effects", "of", "phencyclidine", "(", "C1418873#ent", "<e2>", ")", ",", "a", "drug", "widely", "used", "to", "model", "schizophrenia", ",", "in", "mice", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418873", "name": "C1418873#ent", "pos": [11, 12]}}
{"token": ["However", ",", "in", "contrast", "to", "the", "C0047532#ent", "<e1>", "of", "the", "C0014442#ent", "<e2>", ",", "their", "hydroxysteroid", "oxidase", "was", "potently", "inhibited", "by", "low", "micromolar", "concentrations", "of", "the", "opposing", "cofactor", "(", "NADPH", ")", "."], "h": {"id": "C0047532", "name": "C0047532#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "assess", "the", "prevalence", "and", "pattern", "of", "neuropsychological", "impairment", "cohorts", "of", "C3854222#ent", "<e1>", "individuals", "across", "pre-", "and", "post-HAART", "(", "highly", "active", "antiretroviral", "therapy", "C1415714#ent", "<e2>", "."], "h": {"id": "C3854222", "name": "C3854222#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415714", "name": "C1415714#ent", "pos": [29, 30]}}
{"token": ["This", "lesion", "scoring", "system", "was", "useful", "in", "determining", "the", "severity", "of", "C0022104#ent", "<e1>", "in", "different-aged", "progeny", "from", "IBD-immune", "and", "C0455988#ent", "<e2>", "dams", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [19, 20]}}
{"token": ["The", "data", "provide", "evidence", "for", "a", "C0017366#ent", "<e1>", "genetic", "heterogeneity", "the", "new", "disease", "of", "C0268125#ent", "<e2>", "T", "cell", "dysfunction"], "h": {"id": "C0017366", "name": "C0017366#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0268125", "name": "C0268125#ent", "pos": [14, 15]}}
{"token": ["C0002438#ent", "<e1>", "is", "a", "C0030499#ent", "<e2>", "by", "Entamoeba", "histolytica"], "h": {"id": "C0002438", "name": "C0002438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [4, 5]}}
{"token": ["These", "results", "indicate", "that", "autophosphorylation", "at", "critical", "tyrosine", "residues", "is", "required", "for", "activation", "of", "the", "kinase", "activity", "C0029011#ent", "<e1>", "and", "for", "cell", "transformation", "this", "C1417123#ent", "<e2>", "."], "h": {"id": "C0029011", "name": "C0029011#ent", "pos": [17, 18]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [24, 25]}}
{"token": ["The", "elaborated", "amino-acid", "sequence", "the", "structure", "of", "porcine", "C1367710#ent", "<e1>", "proposed", "earlier", "by", "Gerard", "and", "C2984546#ent", "<e2>", ",", "with", "one", "exception", "."], "h": {"id": "C1367710", "name": "C1367710#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2984546", "name": "C2984546#ent", "pos": [15, 16]}}
{"token": ["We", "also", "found", "that", "expression", "levels", "of", "mRNAs", "for", "eIF-4A", "and", "a", "novel", "C0017337#ent", "<e1>", "are", "increased", "by", "C-type", "natriuretic", "peptide", "C1417809#ent", "<e2>", ")", "stimuli", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417809", "name": "C1417809#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "neither", "inhibition", "of", "MAO", "nor", "oxidative", "cleavage", "this", "C0014442#ent", "<e1>", "to", "yield", "C0061596#ent", "<e2>", "plays", "the", "major", "role", "in", "the", "anticonvulsant", "action", "these", "compounds", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0061596", "name": "C0061596#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "thapsigargin", ",", "an", "inhibitor", "of", "sarco(endo)plasmic", "reticulum", "Ca(2", "+", ")", "C0001473#ent", "<e1>", ",", "remarkably", "decreased", "stretch-induced", "C1334089#ent", "<e2>", "secretion", "from", "CFb", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [19, 20]}}
{"token": ["C0631761#ent", "<e1>", "was", "hypermethylated", ",", "and", "Qp", "was", "unmethylated", "in", "both", "C0029896#ent", "<e2>", "."], "h": {"id": "C0631761", "name": "C0631761#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["This", "little", "aggressive", "surgical", "operation", "is", "indicated", "for", "very", "C0030193#ent", "<e1>", "forms", "of", "pancreatic", "cancer", "for", "some", "cases", "of", "C0149521#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [19, 20]}}
{"token": ["C0039496#ent", "<e1>", "complicate", "fatal", "C0007194#ent", "<e2>"], "h": {"id": "C0039496", "name": "C0039496#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007194", "name": "C0007194#ent", "pos": [4, 5]}}
{"token": ["C1412785#ent", "<e1>", "originally", "identified", "as", "a", "novel", "Bcl-2-interacting", "protein", "but", "co-immunoprecipitation", "studies", "suggest", "that", "the", "major", "physiological", "partner", "for", "C1412785#ent", "<e1>", "the", "mammalian", "C2936441#ent", "<e1>", "PI", "3-kinase", "Vps34", "."], "h": {"id": "C1412785", "name": "C1412785#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2936441", "name": "C2936441#ent", "pos": [23, 24]}}
{"token": ["They", "are", "known", "to", "cause", "C0011603#ent", "<e1>", ",", "conjunctivitis", ",", "rhinitis", ",", "pharyngitis", ",", "and", "C0149514#ent", "<e2>", "in", "humans", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [15, 16]}}
{"token": ["C0270627#ent", "<e1>", "TM", ")", "as", "a", "manifestation", "of", "an", "C0021390#ent", "<e2>", "relatively", "rare", "."], "h": {"id": "C0270627", "name": "C0270627#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [9, 10]}}
{"token": ["These", "data", "establish", "that", "IP3Rs", "are", "essential", "and", "functionally", "redundant", "C0127400#ent", "<e1>", "for", "both", "BCR-", "and", "muscarinic", "C1333530#ent", "<e2>", "calcium", "mobilization", ",", "but", "not", "for", "thapsigargin-induced", "Ca2", "+", "influx", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333530", "name": "C1333530#ent", "pos": [17, 18]}}
{"token": ["C0017337#ent", "<e1>", "such", "as", "RET/PTC", ",", "C0034678#ent", "<e2>", "and", "BRAF", "are", "usually", "involved", "in", "thyroid", "carcinogenesis", "this", "age", "group"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [6, 7]}}
{"token": ["C0256103#ent", "<e1>", "(", "0.3", "microM", ")", "blocked", "the", "maximal", "response", "to", "C0282211#ent", "<e2>", "but", "not", "to", "sodium", "nitroprusside", "that", "C0256103#ent", "<e1>", "did", "selectively", "activate", "protein", "kinase", "C", "these", "experimental", "conditions"], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [0, 1]}}
{"token": ["NT2-N", "neurons", "exhibited", "a", "significantly", "higher", "rate", "of", "C4277588#ent", "<e1>", "NT2", "precursor", "cells", "response", "to", "direct", "activation", "of", "either", "G", "proteins", "C2987154#ent", "<e2>", "."], "h": {"id": "C4277588", "name": "C4277588#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [21, 22]}}
{"token": ["We", "report", "an", "unusual", "case", "of", "nephrotic", "syndrome", "to", "C0017665#ent", "<e1>", "responded", "to", "C0041044#ent", "<e2>", "TMP-SMX", ")", "treatment", "."], "h": {"id": "C0017665", "name": "C0017665#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [13, 14]}}
{"token": ["The", "plasmocid-induced", "stimulation", "of", "alpha-actinin", "loss", "at", "3", "h", ",", "when", "no", "increases", "of", "C0020289#ent", "<e1>", ",", "could", "be", "inhibited", "by", "a", "cysteine", "protease", "inhibitor", "C0116287#ent", "<e2>", "(", "E-64-c", ")", ",", "and", "EGTA", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0116287", "name": "C0116287#ent", "pos": [25, 26]}}
{"token": ["In", "the", "University", "Hospital", "Kuala", "Lumpur", ",", "from", "1984", "to", "1990", ",", "184", "patients", "with", "C0001309#ent", "<e1>", "examined", "for", "C0008149#ent", "<e2>", "direct", "immunofluorescence"], "h": {"id": "C0001309", "name": "C0001309#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0008149", "name": "C0008149#ent", "pos": [19, 20]}}
{"token": ["Vagotomy", "affected", "neither", "the", "occurence", "of", "C1417867#ent", "<e1>", "contractions", "nor", "the", "increase", "in", "C1417190#ent", "<e2>", "level", "produced", "by", "L-NNA", "."], "h": {"id": "C1417867", "name": "C1417867#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417190", "name": "C1417190#ent", "pos": [13, 14]}}
{"token": ["C0057492#ent", "<e1>", "produced", "similar", "C0596110#ent", "<e2>", "and", "antinatriuretic", "responses", "as", "were", "seen", "in", "rats", "with", "an", "intact", "renal", "innervation"], "h": {"id": "C0057492", "name": "C0057492#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [4, 5]}}
{"token": ["Central", "administration", "the", "selective", "mu", "opioid", "agonist", ",", "C0057492#ent", "<e1>", ",", "produces", "a", "concurrent", "C0596110#ent", "<e2>", "and", "antinatriuretic", "response", "conscious", "rats", "."], "h": {"id": "C0057492", "name": "C0057492#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [14, 15]}}
{"token": ["In", "school", "children", "C0004096#ent", "<e1>", "beneficial", "effects", "of", "disodium", "cromoglycate", "DSCG", ")", "and", "C0004906#ent", "<e2>", "BDP", ")", "are", "well-established", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0004906", "name": "C0004906#ent", "pos": [13, 14]}}
{"token": ["Non-insulin", "dependent", "diabetic", "patients", "with", "C0017661#ent", "<e1>", "had", "significantly", "higher", "plasma", "angiotensin", "II", "(", "28.99+/-5.88", "pg/ml", ")", "than", "C0342257#ent", "<e2>", "p<0.001", ")", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0342257", "name": "C0342257#ent", "pos": [18, 19]}}
{"token": ["From", "these", "data", "and", "review", "of", "the", "literature", "the", "possibility", "of", "the", "greater", "risk", "of", "individuals", "with", "a", "single", "kidney", "present", "C0017661#ent", "<e1>", "in", "the", "case", "of", "coexistence", "of", "C0342257#ent", "<e2>"], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0342257", "name": "C0342257#ent", "pos": [29, 30]}}
{"token": ["Hyperlipoproteinemia", "is", "considered", "to", "be", "one", "of", "the", "major", "risk", "factors", "C0003850#ent", "<e1>", "and", "the", "development", "of", "C0003850#ent", "<e1>", "depends", "on", "the", "C0020481#ent", "<e1>"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020481", "name": "C0020481#ent", "pos": [22, 23]}}
{"token": ["The", "diuretic", "action", "C0076670#ent", "<e1>", "was", "dose-relatedly", "reduced", "by", "the", "C3537230#ent", "<e2>", "naloxone", "and", "MR", "2266", "."], "h": {"id": "C0076670", "name": "C0076670#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537230", "name": "C3537230#ent", "pos": [10, 11]}}
{"token": ["Nine", "patients", "wih", "C0156147#ent", "<e1>", "six", "healthy", "individuals", "were", "given", "400", "mg", "C0025872#ent", "<e2>", "twice", "daily", "and", "the", "concentration", "was", "measured", "in", "plasma", "and", "faeces", "6", "to", "8", "h", "after", "intake", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "suggest", "that", "negative", "skin", "or", "liver", "biopsy", "specimens", "in", "patients", "with", "progressive", "C0393702#ent", "<e1>", "not", "exclude", "the", "diagnosis", "of", "C0751783#ent", "<e2>"], "h": {"id": "C0393702", "name": "C0393702#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751783", "name": "C0751783#ent", "pos": [21, 22]}}
{"token": ["Cl-IB-MECA-mediated", "increases", "in", "cAMP", "accumulation", "suggest", "that", "A(3)AR-induced", "ERK1/2", "phosphorylation", "involves", "C0001492#ent", "<e1>", "activation", "via", "phospholipase", "C", "C0031669#ent", "<e2>", ")", "and", "PKC", "stimulation", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [17, 18]}}
{"token": ["C1723260#ent", "<e1>", "is", "thus", "required", "for", "correct", "C0009325#ent", "<e2>", "folding", "and", "therefore", "for", "fat", "tissue", "cohesion", "adipocyte", "function"], "h": {"id": "C1723260", "name": "C1723260#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [7, 8]}}
{"token": ["Only", "1", "C1863753#ent", "<e1>", "sample", "stained", "focally", "for", "C0080279#ent", "<e2>", "(", "+", "1", ")", "."], "h": {"id": "C1863753", "name": "C1863753#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0080279", "name": "C0080279#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "there", "are", "a", "number", "of", "differences", "between", "C0038358#ent", "<e1>", "duodenal", "ulcers", "terms", "of", "the", "quality", "of", "ulcer", "healing", "C0050940#ent", "<e2>", "treatment", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0050940", "name": "C0050940#ent", "pos": [22, 23]}}
{"token": ["This", "increase", "in", "neutrophil", "adhesion", "by", "C1413233#ent", "<e1>", "Abs", "was", "blocked", "by", "a", "C1334146#ent", "<e2>", "was", "associated", "with", "up-regulation", "of", "CD11/CD18", "and", "down-regulation", "of", "CD62L", "on", "the", "neutrophil", "surface"], "h": {"id": "C1413233", "name": "C1413233#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334146", "name": "C1334146#ent", "pos": [13, 14]}}
{"token": ["Cross-linking", "of", "Fc", "gamma", "RIIIA", "CD16", ")", "receptor", "on", "natural", "killer", "NK", ")", "cells", "induces", "receptor-associated", "tyrosine", "kinase", "activation", "tyrosine", "phosphorylation", "numerous", "intracellular", "proteins", "including", "phospholipase", "C", "(PLC)-gamma", "1", ",", "C0250414#ent", "<e1>", "the", "associated", "C3889400#ent", "<e2>"], "h": {"id": "C0250414", "name": "C0250414#ent", "pos": [30, 31]}, "relation": "NA", "t": {"id": "C3889400", "name": "C3889400#ent", "pos": [34, 35]}}
{"token": ["86", "patients", "with", "chronic", "obstructive", "pulmonary", "diseases", "COPD", ")", "and", "C0041323#ent", "<e1>", "in", "combination", "with", "COPD", "complicated", "by", "C0238074#ent", "<e2>", "CPH", ")", "received", "a", "18-month", "continuous", "treatment", "enalapril", "(", "enap", ",", "D.", "Reddis", "Laboratories", ")", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0238074", "name": "C0238074#ent", "pos": [18, 19]}}
{"token": ["Tuberculosis", "was", "shown", "to", "be", "the", "main", "cause", "of", "death", "in", "50.9", "%", "of", "the", "cases", "including", "consequences", "of", "C0041323#ent", "<e1>", ",", "for", "instance", "C0238074#ent", "<e2>"], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0238074", "name": "C0238074#ent", "pos": [24, 25]}}
{"token": ["This", "study", "presents", "a", "new", "diagnostic", "approach", "C0041323#ent", "<e1>", ",", "focusing", "on", "the", "skeletal", "manifestations", "C0238074#ent", "<e2>", "which", "comprises", "approximately", "90", "%", "of", "human-form", "tuberculosis", ")", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0238074", "name": "C0238074#ent", "pos": [15, 16]}}
{"token": ["The", "evolution", "of", "C0041323#ent", "<e1>", "treatment", "considerably", "reduced", "the", "number", "of", "cases", "of", "C0238074#ent", "<e2>", "tubercular", "etiology", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0238074", "name": "C0238074#ent", "pos": [13, 14]}}
{"token": ["Additionally", ",", "several", "strategies", "for", "preventing", "arrhythmias", "such", "as", "prophylactic", "C0023660#ent", "<e1>", "use", "and", "routine", "long-term", "suppression", "of", "premature", "ventricular", "contractions", "C0003195#ent", "<e2>", "no", "longer", "routinely", "advocated", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [10, 11]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [21, 22]}}
{"token": ["The", "antiarrhythmic", "efficacy", "of", "mexiletine", "hydrochloride", "studied", "in", "ten", "selected", "patients", "with", "stable", "resistant", "ventricular", "ectopic", "activity", "in", "whom", "C0023660#ent", "<e1>", ",", "procainamide", ",", "and", "other", "C0003195#ent", "<e2>", "of", "no", "avail", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [19, 20]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [26, 27]}}
{"token": ["C0023660#ent", "<e1>", "is", "a", "commonly", "used", "and", "efficacious", "C0003195#ent", "<e2>", "pharmacokinetics", "after", "a", "rapid", "intravenous", "bolus", "injection", "have", "been", "extensively", "studied", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "if", "patients", "with", "C0409651#ent", "<e1>", "RA", ")", "have", "abnormally", "elevated", "concentrations", "of", "cardiac", "troponin-I", "C3538828#ent", "<e2>", ")", "."], "h": {"id": "C0409651", "name": "C0409651#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538828", "name": "C3538828#ent", "pos": [16, 17]}}
{"token": ["Diabetic", "foot", "lesions", "develop", "predominantly", "in", "male", "patients", "and", "C0151313#ent", "<e1>", "the", "most", "frequent", "type", "of", "C0021847#ent", "<e2>", "associated", "with", "lesions", "."], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [16, 17]}}
{"token": ["Reconstituted", "C1418520#ent", "<e1>", "functions", "as", "an", "C0101555#ent", "<e2>", "a", "variety", "of", "fluorescently", "labelled", "membrane", "lipids"], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [6, 7]}}
{"token": ["These", "findings", "indicate", "that", "the", "heterologous", "reduction", "of", "C1415063#ent", "<e1>", "by", "insulin", "occurs", "via", "transcriptional", "downregulation", "and", "the", "C1512488#ent", "<e2>", "reduction", "of", "C1415063#ent", "<e1>", "by", "GH", "occurs", "via", "a", "different", "mechanism", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1415063", "name": "C1415063#ent", "pos": [8, 9]}}
{"token": ["Pharmacotherapy", "is", "based", "on", "5", "groups", "of", "hypolipidemics", "agents", "A", "--", "Resins", "(", "C0008402#ent", "<e1>", "and", "colestipol", ")", "B", "--", "Nicotinic", "acid", "C", "C0033215#ent", "<e2>", "Fibric", "acids", "gemfibrozil", ")", "E", "--", "Reductase", "inhibitors", "lovastatin", ")", "."], "h": {"id": "C0008402", "name": "C0008402#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033215", "name": "C0033215#ent", "pos": [23, 24]}}
{"token": ["The", "Tec", "family", "kinase", "Btk", "plays", "an", "important", "role", "in", "the", "regulation", "of", "C0662760#ent", "<e1>", "PLC", "gamma", "2", "downstream", "of", "the", "collagen", "receptor", "glycoprotein", "VI", "C1422611#ent", "<e2>", ")", "in", "human", "platelets", "."], "h": {"id": "C0662760", "name": "C0662760#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1422611", "name": "C1422611#ent", "pos": [25, 26]}}
{"token": ["C1515406#ent", "<e1>", "a", "1.8-fold", "increase", "in", "C2349086#ent", "<e2>", "mRNA", "levels", "after", "4", "hours", ",", "followed", "by", "a", "decline", "to", "basal", "levels", "18", "hours", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [6, 7]}}
{"token": ["IBD", "patients", "have", "a", "markedly", "elevated", "risk", "for", "developing", "C0001339#ent", "<e1>", "well", "as", "C0267963#ent", "<e2>"], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0267963", "name": "C0267963#ent", "pos": [13, 14]}}
{"token": ["The", "1503", "C2827459#ent", "<e1>", "present", "only", "in", "patients", "with", "C0027765#ent", "<e2>"], "h": {"id": "C2827459", "name": "C2827459#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [9, 10]}}
{"token": ["The", "monoamine", "and", "glutamate", "agonists", "induced", "Fos-like", "protein", "in", "striatal", "neurons", "that", "C0907533#ent", "<e1>", "expressed", "the", "protein", "phosphatase", "inhibitor", "DARPP-32", "(", "dopamine", "and", "C0056694#ent", "<e2>", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0056694", "name": "C0056694#ent", "pos": [23, 24]}}
{"token": ["The", "Stom-Vent", "2", "C0115685#ent", "<e1>", "filter", "and", "the", "Adeva", "Window", "C1413816#ent", "<e2>", "with", "an", "Adeva", "filter", "the", "lowest", "airflow", "resistance", "of", "the", "devices", "measured", "in", "this", "study", "."], "h": {"id": "C0115685", "name": "C0115685#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413816", "name": "C1413816#ent", "pos": [10, 11]}}
{"token": ["Transcranial", "Doppler", "TCD", ")", "is", "used", "to", "select", "children", "with", "C0002895#ent", "<e1>", "SCD", ")", "for", "C0038454#ent", "<e2>", "prevention", "using", "regular", "blood", "transfusion"], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [15, 16]}}
{"token": ["C0235222#ent", "<e1>", "a", "common", "accompaniment", "of", "C3665349#ent", "<e2>", "."], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3665349", "name": "C3665349#ent", "pos": [6, 7]}}
{"token": ["Fasciola", "hepatica", "antigens", "were", "isolated", "from", "intact", "worms", "in", "the", "C0041912#ent", "<e1>", "by", "using", "C0068941#ent", "<e2>"], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0068941", "name": "C0068941#ent", "pos": [14, 15]}}
{"token": ["A", "C1421143#ent", "<e1>", "stimulation", "test", "performed", "and", "the", "binding", "capacity", "of", "TBG", "and", "C2699876#ent", "<e2>", "for", "T3", "and", "T4", "measured", "by", "reverse", "flow", "zone", "electrophoresis", "in", "a", "group", "of", "these", "patients", "."], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2699876", "name": "C2699876#ent", "pos": [13, 14]}}
{"token": ["The", "C1333247#ent", "<e1>", "mutation", "is", "recessive", "and", "maps", "to", "chromosome", "1", "molecular", "markers", "C0004135#ent", "<e2>", "and", "NCC1", "."], "h": {"id": "C1333247", "name": "C1333247#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [13, 14]}}
{"token": ["The", "intent", "of", "this", "descriptive", "study", "to", "determine", "norms", "of", "resource", "utilization", "for", "the", "congestive", "heart", "failure", "C0019099#ent", "<e1>", ")", "patients", "admitted", "and", "discharged", "from", "a", "not-for-profit", "home", "health", "agency", "C0162809#ent", "<e2>", ")", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0162809", "name": "C0162809#ent", "pos": [30, 31]}}
{"token": ["We", "established", "the", "genomic", "organisation", "the", "C1427464#ent", "<e1>", "screened", "a", "C1418706#ent", "<e2>", "pedigree", "for", "mutations", "in", "the", "coding", "region"], "h": {"id": "C1427464", "name": "C1427464#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418706", "name": "C1418706#ent", "pos": [10, 11]}}
{"token": ["Taken", "together", ",", "C3713819#ent", "<e1>", "apoptosis", "in", "A375-S2", "cells", "via", "accumulation", "of", "C1705526#ent", "<e2>", ",", "alters", "the", "Bax/Bcl-2", "ratio", ",", "and", "activates", "caspases", "and", "p38/JNK", "MAPKs", "."], "h": {"id": "C3713819", "name": "C3713819#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [12, 13]}}
{"token": ["Thrombin", "that", "escapes", "into", "the", "circulation", "is", "efficiently", "inactivated", "by", "C0003015#ent", "<e1>", "such", "as", "C0003438#ent", "<e2>", ",", "or", "is", "sequestered", "by", "thrombomodulin", "on", "the", "endothelium", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "C0017922#ent", "<e1>", "GSD1b", ")", "not", "only", "show", "hepatomegaly", ",", "C0020615#ent", "<e2>", "and", "lactic", "acidosis", "but", "also", "neutropenia", "and", "neutrophil", "dysfunction"], "h": {"id": "C0017922", "name": "C0017922#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [11, 12]}}
{"token": ["with", "the", "cholestatic", "dyes", "bromcresol", "green", "BCG", ",", "30", "micromol/kg", ")", "and", "rose", "bengal", "(", "C0694889#ent", "<e1>", ",", "60", "micromol/kg", ")", "immediately", "prior", "C0000970#ent", "<e2>", "administration", "(", "500", "mg/kg", ",", "i.p", ".", ")", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [23, 24]}}
{"token": ["Pretreatment", "with", "the", "cholestatic", "dyes", "BCG", "and", "C0694889#ent", "<e1>", "decreased", "the", "severity", "of", "hepatocellular", "necrosis", "induced", "by", "C0000970#ent", "<e2>", "."], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [17, 18]}}
{"token": ["Adult", "C0018889#ent", "<e1>", "isolated", "from", "patients", "treated", "with", "C0025023#ent", "<e2>", "showed", "a", "reduction", "in", "mobility", "and", "contained", "40", "times", "fewer", "developing", "microfilarial", "forms", "than", "did", "C0018889#ent", "<e1>", "from", "untreated", "patients", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [1, 2]}, "relation": "may_be_prevented_by", "t": {"id": "C0025023", "name": "C0025023#ent", "pos": [8, 9]}}
{"token": ["C0018889#ent", "<e1>", "were", "obtained", "from", "mice", "treated", "with", "C0025023#ent", "<e2>", "or", "albendazole", ",", "and", "the", "glycoconjugates", "were", "localized", "in", "the", "parasite", "tissues", "by", "cytochemistry", "using", "lectin-gold", "conjugates", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0025023", "name": "C0025023#ent", "pos": [8, 9]}}
{"token": ["Vesicles", "were", "seen", "in", "54", "%", "of", "the", "subjects", "patched", "with", "1", "%", "C0885449#ent", "<e1>", "in", "70", "%", "IPA", "at", "C1412526#ent", "<e2>", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412526", "name": "C1412526#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "the", "substitutions", "of", "C2984553#ent", "<e1>", "by", "ESV", "together", "with", "C1420753#ent", "<e2>", "by", "WNP", "have", "a", "largely", "cooperative", "and", "hardly", "predictable", "effect", "."], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420753", "name": "C1420753#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "have", "investigated", "whether", "Syk", "is", "part", "of", "the", "Wnt-5a/discoidin", "domain", "receptor-1", "(", "DDR1", ")", "signaling", "pathway", "if", "a", "signaling", "interaction", "of", "these", "C0086376#ent", "<e1>", "is", "important", "for", "C1335851#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1335851", "name": "C1335851#ent", "pos": [30, 31]}}
{"token": ["Malignant", "cells", "C1367472#ent", "<e1>", "were", "characterized", "by", "low", "activities", "C0001457#ent", "<e2>", ",", "PNP", "and", "5'NT", "."], "h": {"id": "C1367472", "name": "C1367472#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001457", "name": "C0001457#ent", "pos": [9, 10]}}
{"token": ["Although", "C0239946#ent", "<e1>", "a", "well-known", "consequence", "of", "C0017922#ent", "<e2>", "until", "now", "only", "eight", "cases", "of", "liver", "cirrhosis", "two", "cases", "of", "hepatocellular", "carcinoma", "been", "described", "in", "patients", "affected", "by", "this", "disease", "."], "h": {"id": "C0239946", "name": "C0239946#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0017922", "name": "C0017922#ent", "pos": [7, 8]}}
{"token": ["Here", ",", "mice", "expressing", "rabbit", "C1413766#ent", "<e1>", "(", "rbCRP", ")", "were", "crossbred", "onto", "C1412481#ent", "<e2>", "knockout", "animals", "and", "the", "effect", "on", "atherogenesis", "was", "studied", "."], "h": {"id": "C1413766", "name": "C1413766#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [13, 14]}}
{"token": ["More", "importantly", ",", "C3890229#ent", "<e1>", "interacts", "with", "Apaf-1", "and", "forms", "a", "multimeric", "protein", "complex", "Apaf-1", "and", "C1705066#ent", "<e2>", "."], "h": {"id": "C3890229", "name": "C3890229#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705066", "name": "C1705066#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "C3275275#ent", "<e1>", "also", "known", "as", "C1423931#ent", "<e2>", "Fiaf", ",", "was", "uncovered", "as", "a", "novel", "modulator", "of", "plasma", "lipoprotein", "metabolism"], "h": {"id": "C3275275", "name": "C3275275#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1423931", "name": "C1423931#ent", "pos": [7, 8]}}
{"token": ["Pre-treatment", "with", "blocking", "agents", "such", "as", "the", "glucocorticoid", "receptor", "antagonist", "C0701303#ent", "<e1>", ",", "or", "the", "C0001644#ent", "<e2>", "propranolol", ",", "eliminated", "this", "increase", "in", "damage", "."], "h": {"id": "C0701303", "name": "C0701303#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [15, 16]}}
{"token": ["C1420884#ent", "<e1>", "enhances", "covalent", "modification", "the", "inter-alpha-trypsin", "inhibitor", "C1420801#ent", "<e2>", "and", "transfer", "of", "its", "heavy", "chains", "hyaluronan", ",", "suggesting", "a", "physiological", "function", "C1420884#ent", "<e1>", "binding", "to", "C1420801#ent", "<e2>", "in", "regulation", "of", "hyaluronan", "metabolism", "at", "sites", "of", "inflammation", "."], "h": {"id": "C1420884", "name": "C1420884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420801", "name": "C1420801#ent", "pos": [8, 9]}}
{"token": ["Progressive", "multifocal", "leukoencephalopathy", "C1366903#ent", "<e1>", ")", "is", "a", "rare", "disease", "related", "to", "a", "C0042769#ent", "<e2>", "the", "central", "nervous", "system", "it", "is", "usually", "seen", "in", "patients", "who", "have", "impaired", "immunologic", "function"], "h": {"id": "C1366903", "name": "C1366903#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [13, 14]}}
{"token": ["Dapsone-induced", "photosensitivity", "is", "a", "rare", ",", "non-dose-related", "adverse", "effect", "of", "the", "C0038761#ent", "<e1>", "and", "can", "occur", "in", "patients", "with", "inflammatory", "skin", "disorders", "treated", "with", "C1639494#ent", "<e2>", "."], "h": {"id": "C0038761", "name": "C0038761#ent", "pos": [11, 12]}, "relation": "chemical_structure_of", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [24, 25]}}
{"token": ["However", ",", "ETir", "excretion", "was", "unchanged", "in", "children", "with", "idiopathic", "steroid", "sensitive", "C0027726#ent", "<e1>", "with", "stable", "chronic", "glomerulonephritis", "in", "4", "patients", "with", "C0019061#ent", "<e2>"], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0019061", "name": "C0019061#ent", "pos": [22, 23]}}
{"token": ["Previously", "reported", "associations", "of", "reversible", "posterior", "leukoencephalopathy", "syndrome", "hypertension", ",", "vasculitis", ",", "C0027726#ent", "<e1>", "severe", "hypercalcemia", ",", "C0019061#ent", "<e2>", "eclampsia", ",", "renal", "failure", "and", "use", "of", "immunosuppressive", "drugs"], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0019061", "name": "C0019061#ent", "pos": [17, 18]}}
{"token": ["C0265215#ent", "<e1>", "a", "rare", "C1848862#ent", "<e2>", "inherited", "as", "Mendelian", "autosomal", "condition", "."], "h": {"id": "C0265215", "name": "C0265215#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}}
{"token": ["Cytokines", "shown", "to", "affect", "C0534137#ent", "<e1>", "are", "interferon", "(", "C1415900#ent", "<e2>", ")", ",", "interleukin", "1", "IL-1", ")", ",", "tumor", "necrosis", "factor", "TNF", ")", ",", "and", "interleukin", "6", "IL-6", ")", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [9, 10]}}
{"token": ["C0534137#ent", "<e1>", "mRNA", "responded", "only", "to", "IL-6", "and", "C1415900#ent", "<e2>", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [8, 9]}}
{"token": ["Conclusively", ",", "C0006309#ent", "<e1>", "must", "be", "considered", "as", "a", "cause", "of", "C0029191#ent", "<e2>", "in", "especially", "endemic", "regions", "where", "cattle", "dealing", "is", "widespread", "."], "h": {"id": "C0006309", "name": "C0006309#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029191", "name": "C0029191#ent", "pos": [11, 12]}}
{"token": ["Nerve", "cells", "immunoreactive", "to", "somatostatin", ",", "substance", "P", "VIP", ",", "C1704947#ent", "<e1>", ",", "NPY", ",", "bombesin", "and", "C1704715#ent", "<e2>", "were", "detected", "."], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704715", "name": "C1704715#ent", "pos": [17, 18]}}
{"token": ["The", "influence", "of", "the", "initial", "substrate", "to", "microorganisms", "ratio", "(", "So/Xo", ")", "on", "the", "inhibition", "of", "the", "C0067320#ent", "<e1>", "production", "caused", "by", "C0048197#ent", "<e2>", ",", "4CP", ",", "was", "studied", "."], "h": {"id": "C0067320", "name": "C0067320#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0048197", "name": "C0048197#ent", "pos": [22, 23]}}
{"token": ["The", "genomic", "DNA", "an", "intronless", "C3715179#ent", "<e1>", "whose", "deduced", "amino", "acid", "sequence", "a", "C1332718#ent", "<e2>", "some", "amino", "acid", "residues", "characteristic", "of", "vertebrate", "olfactory", "receptors", "ORs", ")", "."], "h": {"id": "C3715179", "name": "C3715179#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332718", "name": "C1332718#ent", "pos": [13, 14]}}
{"token": ["C0041323#ent", "<e1>", "is", "a", "disease", "of", "C0029166#ent", "<e2>", "and", "despite", "a", "falling", "incidence", "is", "still", "prevalent", "in", "our", "society", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [6, 7]}}
{"token": ["This", "study", "presents", "a", "new", "diagnostic", "approach", "C0041323#ent", "<e1>", ",", "focusing", "on", "the", "C0029166#ent", "<e2>", "chronic", "pulmonary", "disease", "which", "comprises", "approximately", "90", "%", "of", "human-form", "tuberculosis", ")", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [13, 14]}}
{"token": ["Thereby", ",", "C1415760#ent", "<e1>", "and", "Bag-6/Bat-3/Scythe", "were", "identified", "as", "novel", "C3538854#ent", "<e2>", "interaction", "partners", "while", "interaction", "with", "Hsc70", "was", "confirmed", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3538854", "name": "C3538854#ent", "pos": [10, 11]}}
{"token": ["Oral", "diseases", "prevalent", "conditions", ";", "dental", "caries", "the", "most", "common", "C0494827#ent", "<e1>", "and", "adult", "C0747479#ent", "<e2>", "up", "to", "40", "%", "of", "reproductive-aged", "women", "."], "h": {"id": "C0494827", "name": "C0494827#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0747479", "name": "C0747479#ent", "pos": [14, 15]}}
{"token": ["At", "the", "end", ",", "the", "C0039082#ent", "<e1>", "was", "coined", "Meigs'", "syndrome", "Rhodes", "and", "C1587944#ent", "<e2>", "in", "1937", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1587944", "name": "C1587944#ent", "pos": [13, 14]}}
{"token": ["At", "present", ",", "it", "is", "not", "known", "whether", "C1825346#ent", "<e1>", "increases", "in", "response", "to", "insulin-induced", "C0020615#ent", "<e2>", "."], "h": {"id": "C1825346", "name": "C1825346#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [15, 16]}}
{"token": ["Plasma", "phosphorus", "and", "C2936886#ent", "<e1>", "was", "significantly", "higher", "for", "hens", "with", "C3540811#ent", "<e2>", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540811", "name": "C3540811#ent", "pos": [11, 12]}}
{"token": ["C1412628#ent", "<e1>", "(", "P", "=", "0.008", ")", "and", "C1412630#ent", "<e2>", "(", "P", "=", "0.038", ")", "mRNA", "expression", "were", "significantly", "reduced", "during", "CPB", "."], "h": {"id": "C1412628", "name": "C1412628#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412630", "name": "C1412630#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "a", "synergistic", "relationship", "in", "fibrin", "formation", "existed", "in", "mice", "with", "concomitant", "modifications", "of", "C0078956#ent", "<e1>", "and", "TM", ",", "resulting", "in", "C0027051#ent", "<e2>", "depressed", "cardiac", "function"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [22, 23]}}
{"token": ["To", "examine", "quantitative", "changes", "of", "elastin", ",", "fibrillin", "and", "collagen", "in", "abdominal", "aortic", "aneurysms", "including", "ruptured", "abdominal", "aortic", "aneurysms", "RAAA", ")", ",", "C0002950#ent", "<e1>", "IAAA", ")", "and", "abdominal", "aortic", "aneurysms", "C1705543#ent", "<e2>", ")", "were", "measured", "."], "h": {"id": "C0002950", "name": "C0002950#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [30, 31]}}
{"token": ["Binding", "to", "the", "other", "extracellular", "matrix", "proteins", "collagen", "type", "1", "C1336937#ent", "<e1>", "was", "not", "observed", ",", "although", "two", "C0812385#ent", "<e2>", "cases", "showed", "some", "binding", "to", "laminin", "."], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [18, 19]}}
{"token": ["The", "conserved", "C0079414#ent", "<e1>", "ligand-receptor", "pair", "Netrin", "and", "Frazzled", "(", "C1858361#ent", "<e2>", ")", "has", "a", "well-established", "role", "in", "axon", "guidance"], "h": {"id": "C0079414", "name": "C0079414#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1858361", "name": "C1858361#ent", "pos": [10, 11]}}
{"token": ["Weak", "trunk", "extensors", "were", "associated", "with", "history", "of", "C0036396#ent", "<e1>", ",", "weak", "trunk", "flexors", "with", "back", "injuries", "with", "current", "C0004604#ent", "<e2>", "at", "work/exercise", "."], "h": {"id": "C0036396", "name": "C0036396#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [19, 20]}}
{"token": ["We", "are", "currently", "investigating", "the", "relevance", "of", "C0211705#ent", "<e1>", "cleavage", "for", "C1822695#ent", "<e2>", "cytotoxicity", "and", "the", "consequences", "for", "the", "activity", "of", "the", "MAP", "pathway"], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1822695", "name": "C1822695#ent", "pos": [11, 12]}}
{"token": ["The", "DNA", "content", "the", "stomach", "and", "the", "C0771711#ent", "<e1>", "were", "greater", "in", "animals", "treated", "with", "C1334089#ent", "<e2>", "or", "IGF-II", "than", "in", "controls", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [15, 16]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "whether", "the", "intact", "rat", "C0771711#ent", "<e1>", "expresses", "mRNAs", "for", "C1334089#ent", "<e2>", ",", "IGF-II", "and", "IGFBPs", ",", "and", "how", "these", "might", "change", "with", "development", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [17, 18]}}
{"token": ["The", "present", "results", "indicate", "that", "in", "Sertoli", "cells", "LNCaP", "cells", ",", "hormonal", "effects", "C0003504#ent", "<e1>", "C0812327#ent", "<e2>", "a", "role", "in", "regulation", "of", "C0003504#ent", "<e1>", "expression", "."], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [13, 14]}}
{"token": ["Among", "the", "C0304402#ent", "<e1>", "and", "blockers", "of", "alpha-", "and", "beta-adrenergic", ",", "cholinergic", ",", "C0162816#ent", "<e2>", ",", "dopaminergic", ",", "serotonergic", ",", "or", "GABAergic", "receptors", "no", "drug", "inhibited", "or", "enhanced", "specific", "(+/-)[3H]benidipine", "binding", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162816", "name": "C0162816#ent", "pos": [13, 14]}}
{"token": ["Previously", ",", "by", "a", "yeast", "2-hybrid", "screen", ",", "we", "identified", "signal", "transducer", "activator", "of", "transcription", "5b", "C1335876#ent", "<e1>", ")", "as", "a", "substrate", "of", "the", "C1334133#ent", "<e2>", "IR", ")", "."], "h": {"id": "C1335876", "name": "C1335876#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [24, 25]}}
{"token": ["By", "contrast", ",", "the", "C1519554#ent", "<e1>", "etoposide", ",", "equally", "activated", "the", "C1704939#ent", "<e2>", ",", "TK", "and", "SV", "40", "promoters", "."], "h": {"id": "C1519554", "name": "C1519554#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [11, 12]}}
{"token": ["Risk", "for", "renal", "insufficiency", "RI", ")", "resulting", "from", "nonsteroidal", "anti-inflammatory", "drugs", "C3536840#ent", "<e1>", ")", "exists", "in", "cirrhosis", "with", "ascites", ",", "nephrotic", "syndrome", "C0018802#ent", "<e2>", "and", "chronic", "renal", "disease"], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [22, 23]}}
{"token": ["The", "rarity", "of", "C0151445#ent", "<e1>", "phenomenon", "and", "significant", "visceral", "changes", "help", "distinguish", "C0059037#ent", "<e2>", "from", "systemic", "scleroderma"], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [12, 13]}}
{"token": ["The", "area", "under", "the", "C0000970#ent", "<e1>", "curve", "was", "also", "significantly", "increased", "by", "C0008269#ent", "<e2>", "administration", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [12, 13]}}
{"token": ["Home", "treatment", "febrile", "episodes", "was", "based", "on", "C0000970#ent", "<e1>", "or", "aspirin", "(", "84", "%", ")", ",", "C0008269#ent", "<e2>", "(", "13", "%", ")", "and", "cotrimoxazole", "(", "2.9", "%", ")", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [16, 17]}}
{"token": ["We", "report", "a", "C0030424#ent", "<e1>", "a", "41-year-old", "Korean", "man", "who", "complains", "a", "C0018681#ent", "<e2>", "and", "weakness", "of", "left", "motor", "neuron", "."], "h": {"id": "C0030424", "name": "C0030424#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [12, 13]}}
{"token": ["The", "ability", "of", "C0074664#ent", "<e1>", "(", "SF", ")", ",", "a", "C0728821#ent", "<e2>", ",", "to", "alter", "blood", "growth", "hormone", "GH", ")", "and", "glucose", "concentrations", "broiler", "chicks", "was", "investigated", "."], "h": {"id": "C0074664", "name": "C0074664#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0728821", "name": "C0728821#ent", "pos": [10, 11]}}
{"token": ["Once", "C1412502#ent", "<e1>", "is", "established", ",", "inhaled", "bronchodilators", ",", "C0243192#ent", "<e2>", "both", "--", "might", "be", "useful", "."], "h": {"id": "C1412502", "name": "C1412502#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [9, 10]}}
{"token": ["32PO4", "attached", "to", "GSIII", "during", "bacterial", "growth", "part", "of", "the", "modifying", "group", "could", "be", "removed", "by", "treatment", "with", "C0148290#ent", "<e1>", "by", "turkey", "erythrocyte", "C1412252#ent", "<e2>"], "h": {"id": "C0148290", "name": "C0148290#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412252", "name": "C1412252#ent", "pos": [23, 24]}}
{"token": ["The", "human", "C1416889#ent", "<e1>", "to", "1q22-q23", ",", "a", "region", "identified", "as", "a", "C0011860#ent", "<e2>", "T2DM", ")", "locus", "in", "several", "different", "populations", "."], "h": {"id": "C1416889", "name": "C1416889#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [12, 13]}}
{"token": ["The", "intravenous", "use", "of", "positive", "C0304509#ent", "<e1>", "such", "as", "C0039052#ent", "<e2>", "and", "phosphodiesterase", "inhibitors", "in", "heart", "failure", "limited", "by", "pro-arrhythmic", "and", "positive", "chronotropic", "effects"], "h": {"id": "C0304509", "name": "C0304509#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [9, 10]}}
{"token": ["In", "severe", "chronic", "congestive", "cardiac", "failure", "physician", "has", "the", "choice", "of", "two", "families", "of", "positive", "C0304509#ent", "<e1>", "the", "direct", "C0039052#ent", "<e2>", "and", "the", "phosphodiesterase", "inhibitors"], "h": {"id": "C0304509", "name": "C0304509#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [19, 20]}}
{"token": ["The", "preliminary", "results", "suggest", "that", "VIP", "may", "be", "involved", "in", "the", "pathophysiological", "procedures", "of", "C0007785#ent", "<e1>", "C3828360#ent", "<e2>", "may", "attenuate", "the", "dysfunction", "of", "VIP", "during", "C0007785#ent", "<e1>"], "h": {"id": "C3828360", "name": "C3828360#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [14, 15]}}
{"token": ["The", "findings", "of", "the", "present", "experiment", "demonstrate", "that", "C3828360#ent", "<e1>", "can", "reduce", "ultrastructural", "abnormalities", "C0007785#ent", "<e2>", "are", "also", "direct", "evidence", "of", "the", "protective", "effect", "C3828360#ent", "<e1>", "on", "C0007785#ent", "<e2>"], "h": {"id": "C3828360", "name": "C3828360#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [14, 15]}}
{"token": ["Analysis", "of", "27", "independent", "C1538716#ent", "<e1>", "patient", "samples", "showed", "no", "evidence", "for", "genomic", "deletions", "to", "C3149841#ent", "<e2>", "."], "h": {"id": "C1538716", "name": "C1538716#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [15, 16]}}
{"token": ["VEGF", "activated", "C1538716#ent", "<e1>", "PKD", ")", "via", "PKC", ",", "and", "siRNAs", "targeted", "to", "C3149841#ent", "<e2>", "and", "PKD2", "inhibited", "VEGF-induced", "HSP27", "serine", "82", "phosphorylation", "."], "h": {"id": "C1538716", "name": "C1538716#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [13, 14]}}
{"token": ["Denaturing", "2-DE", "revealed", "significant", "differences", "in", "the", "relative", "abundance", "of", "the", "membrane", "proteins", "C0039683#ent", "<e1>", "and", "peptidoglycan-associated", "lipoprotein", "several", "metabolic", "C3541394#ent", "<e2>", ",", "and", ",", "in", "addition", ",", "superoxide", "dismutase", "rubredoxin", "oxidoreductase"], "h": {"id": "C0039683", "name": "C0039683#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [20, 21]}}
{"token": ["The", "DX3", "melanoma", "conditioned", "medium", "stimulated", "basal", "secretion", "C0172537#ent", "<e1>", "urokinase", ",", "tissue", "plasminogen", "activator", "and", "tissue", "inhibitors", "C1334706#ent", "<e2>", "."], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [18, 19]}}
{"token": ["Previously", ",", "we", "showed", "that", "C1439337#ent", "<e1>", "activated", "by", "growth", "factors", "and", "C1412097#ent", "<e2>", "is", "required", "for", "transition", "from", "G1", "to", "S", "phase", "PDGF-mediated", "proliferation", "."], "h": {"id": "C1439337", "name": "C1439337#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [12, 13]}}
{"token": ["Ectopic", "expression", "of", "a", "functional", "ATM", "kinase", "domain", "corrects", "this", "defect", ",", "as", "it", "phosphorylates", "the", "C1439337#ent", "<e1>", "in", "vitro", "Ser", "465", ",", "leading", "to", "the", "activation", "of", "C1412097#ent", "<e2>", "."], "h": {"id": "C1439337", "name": "C1439337#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412097", "name": "C1412097#ent", "pos": [28, 29]}}
{"token": ["Werner", "syndrome", "a", "premature", "aging", "disease", "by", "mutations", "in", "the", "C2699843#ent", "<e1>", "a", "deficiency", "in", "the", "function", "of", "Werner", "protein", "C0043119#ent", "<e2>", ")", "."], "h": {"id": "C2699843", "name": "C2699843#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0043119", "name": "C0043119#ent", "pos": [20, 21]}}
{"token": ["Werner", "syndrome", "C2699843#ent", "<e1>", ")", "is", "the", "hallmark", "C0043119#ent", "<e2>", "which", "the", "patients", "appear", "much", "older", "than", "their", "actual", "chronological", "age"], "h": {"id": "C2699843", "name": "C2699843#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0043119", "name": "C0043119#ent", "pos": [8, 9]}}
{"token": ["The", "data", "we", "present", "here", "suggest", "that", "agonists", "of", "peroxisome", "proliferator-activated", "receptor-gamma", "C1335238#ent", "<e1>", ")", "can", "attenuate", "the", "effects", "of", "C0078939#ent", "<e2>", "Abeta", ")", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [20, 21]}}
{"token": ["The", "data", "we", "present", "here", "suggest", "that", "agonists", "of", "C1335238#ent", "<e1>", "PPARgamma", ")", "can", "attenuate", "the", "effects", "of", "C0078939#ent", "<e2>", "Abeta", ")", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [18, 19]}}
{"token": ["Classical", "C0026850#ent", "<e1>", "CMDs", ")", "are", "autosomal", "recessive", "C0751950#ent", "<e2>", "by", "early", "onset", "hypotonia", "and", "weakness", ",", "atrophy", "of", "limbs", "and", "trunk", "muscles", "contractures", ",", "and", "dystrophic", "changes", "in", "the", "muscle", "biopsy"], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [8, 9]}}
{"token": ["Duchenne", "and", "C0026850#ent", "<e1>", "DMD", "and", "BMD", ")", "are", "X-linked", "recessive", "C0751950#ent", "<e2>", "by", "mutations", "in", "the", "dystrophin", "gene", "approximately", "1", "in", "3,500", "males", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [11, 12]}}
{"token": ["The", "inhibitory", "effect", "of", "most", "analgesics", "on", "the", "cyclooxygenase", "initiates", "impairments", "in", "the", "metabolism", "of", "C3540754#ent", "<e1>", "and", "leukotrienes", ",", "which", "are", "suspected", "to", "cause", "the", "C0221725#ent", "<e2>", "intolerant", "patients", "."], "h": {"id": "C3540754", "name": "C3540754#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0221725", "name": "C0221725#ent", "pos": [26, 27]}}
{"token": ["Here", "we", "show", "that", "while", "p65", "NF-kappaB", "nuclear", "translocation", "TNF-treated", "smooth", "muscle", "cells", "SMCs", ")", "was", "sufficient", "for", "the", "expression", "of", "VCAM-1", ",", "expression", "of", "C1706544#ent", "<e1>", "showed", "a", "critical", "requirement", "for", "C1709384#ent", "<e2>", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1709384", "name": "C1709384#ent", "pos": [32, 33]}}
{"token": ["A", "similar", "positional", "cloning", "approach", "C3890421#ent", "<e1>", "as", "the", "C0017337#ent", "<e2>", "responsible", "for", "familial", "TTP", "."], "h": {"id": "C3890421", "name": "C3890421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["More", "than", "10", "rearranged", "forms", "of", "C0694890#ent", "<e1>", ",", "referred", "to", "as", "RET/PTC", "1", "9", ",", "C3274878#ent", "<e2>", "and", "RFP/RET", ",", "have", "been", "cloned", "from", "sporadic", "and", "radiation-associated", "papillary", "thyroid", "carcinomas", "."], "h": {"id": "C0694890", "name": "C0694890#ent", "pos": [6, 7]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274878", "name": "C3274878#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "also", "support", "prior", "information", "suggesting", "the", "association", "between", "EBV", "and", "C0004364#ent", "<e1>", "including", "SLE", ",", "antiphospholipid", "syndrome", "rheumatoid", "arthritis", "C0026769#ent", "<e2>", "pemphigus", "vulgaris", "giant", "cell", "arthritis", "Wegener's", "granulomatosis", "and", "polyarteritis", "nodosa", "PAN", ")", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [21, 22]}}
{"token": ["This", "study", "was", "an", "examination", "of", "the", "role", "of", "progesterone", "(", "C1539372#ent", "<e1>", ")", "and", "estradiol-17beta", "(", "E2", ")", "as", "C0026249#ent", "<e2>", "the", "decidua", "basalis", "DB", ")", "of", "the", "rat", "during", "pregnancy", "."], "h": {"id": "C1539372", "name": "C1539372#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [20, 21]}}
{"token": ["An", "abnormal", "phenotype", "of", "PA-SMCs", "and", "C1522380#ent", "<e1>", "has", "been", "described", "in", "C3203102#ent", "<e2>", "and", "some", "analogies", "now", "appear", "between", "pulmonary", "vascular", "cells", "patients", "with", "C3203102#ent", "<e2>", "and", "cancer", "cells"], "h": {"id": "C1522380", "name": "C1522380#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3203102", "name": "C3203102#ent", "pos": [12, 13]}}
{"token": ["These", "include", "variegate", "porphyria", "C0342856#ent", "<e1>", "with", "manifestations", "of", "photosensitivity", "only", ",", "adult", "onset", "C0687708#ent", "<e2>", "mixed", "porphyrias", "and", "other", "less", "frequent", "porphyrin", "disorders"], "h": {"id": "C0342856", "name": "C0342856#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0687708", "name": "C0687708#ent", "pos": [14, 15]}}
{"token": ["Smad3", "is", "closely", "related", "to", "C1566790#ent", "<e1>", "but", "suppresses", "activation", "of", "the", "C1705359#ent", "<e2>", "promoter", "."], "h": {"id": "C1566790", "name": "C1566790#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705359", "name": "C1705359#ent", "pos": [12, 13]}}
{"token": ["We", "further", "showed", "that", "C1422840#ent", "<e1>", ",", "but", "not", "C3890557#ent", "<e2>", ",", "is", "capable", "of", "adhering", "to", "the", "HSB", "and", "HPB-ALL", "lymphocyte", "cell", "lines", "."], "h": {"id": "C1422840", "name": "C1422840#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890557", "name": "C3890557#ent", "pos": [9, 10]}}
{"token": ["(+)Amphetamine", "and", "C0001975#ent", "<e1>", "were", "tested", "in", "the", "modified", "hole-board", ",", "and", "C0011812#ent", "<e2>", "decreased", "and", "C0001975#ent", "<e1>", "increased", "the", "frequency", "and", "duration", "of", "head-dips", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011812", "name": "C0011812#ent", "pos": [12, 13]}}
{"token": ["C0972314#ent", "<e1>", "is", "a", "selective", "C3536910#ent", "<e2>", "in", "clinical", "studies", "improved", "the", "signs", "and", "symptoms", "of", "osteoarthritis", "and", "rheumatoid", "arthritis", "reduced", "the", "potential", "for", "GI", "injury"], "h": {"id": "C0972314", "name": "C0972314#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536910", "name": "C3536910#ent", "pos": [5, 6]}}
{"token": ["The", "results", "suggest", "a", "mechanism", "by", "which", "PDZ", "C3829284#ent", "<e1>", "be", "coupled", "to", "C1705556#ent", "<e2>", "and", "the", "membrane", "cytoskeleton", "hDlg", "."], "h": {"id": "C3829284", "name": "C3829284#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [13, 14]}}
{"token": ["This", "report", "analyzes", "the", "role", "of", "C1522575#ent", "<e1>", "angiogenesis", "in", "the", "immunoinflammatory", "lesion", "stromal", "keratitis", "induced", "by", "C0015407#ent", "<e2>", "herpes", "simplex", "virus", "HSV", ")", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015407", "name": "C0015407#ent", "pos": [17, 18]}}
{"token": ["Venous", "thromboembolism", "VTE", ")", "manifesting", "as", "C0149871#ent", "<e1>", "DVT", ")", "and", "pulmonary", "embolism", "PE", ")", "remains", "a", "common", "C0042373#ent", "<e2>", "high", "mortality", "morbidity", "."], "h": {"id": "C0149871", "name": "C0149871#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [18, 19]}}
{"token": ["These", "data", "indicate", "that", "C0022575#ent", "<e1>", "can", "present", "alloantigens", ",", "and", "that", "lack", "of", "C2985420#ent", "<e2>", "C0022575#ent", "<e1>", "is", "the", "main", "reason", "why", "these", "cells", "can", "not", "induce", "primary", "T-cell", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2985420", "name": "C2985420#ent", "pos": [14, 15]}}
{"token": ["The", "signalling", "pathways", "two", "adapter", "proteins", "MyD88", "and", "Tollip", ",", "which", "via", "two", "IL-1", "receptor-associated", "kinases", "IRAK", "and", "C0663246#ent", "<e1>", ")", "activate", "transcription", "factors", "as", "nuclear", "factor-kappa", "B", "protein", "kinases", "as", "C1120843#ent", "<e2>"], "h": {"id": "C0663246", "name": "C0663246#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1120843", "name": "C1120843#ent", "pos": [31, 32]}}
{"token": ["Balb/c", "3T3", "cells", "generated", "outward", "currents", "in", "response", "to", "Bn", ",", "GRP", ",", "and", "C3811197#ent", "<e1>", "but", "did", "not", "respond", "to", "both", "AVP", "and", "C1537501#ent", "<e2>", "with", "outward", "current", "flows", "."], "h": {"id": "C3811197", "name": "C3811197#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [24, 25]}}
{"token": ["The", "C3889151#ent", "<e1>", "a", "protein", "originally", "identified", "for", "its", "inhibition", "of", "C0071795#ent", "<e2>", "a", "nuclease", "induced", "by", "interferon", "in", "mammalian", "cells"], "h": {"id": "C3889151", "name": "C3889151#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0071795", "name": "C0071795#ent", "pos": [11, 12]}}
{"token": ["RAD9", "and", "C3815185#ent", "<e1>", "share", "extensive", "C2917660#ent", "<e2>", "homology", "throughout", "their", "entire", "sequences", "(", "36", "%", "identity", ",", "48", "%", "similarity", ")", "."], "h": {"id": "C3815185", "name": "C3815185#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [6, 7]}}
{"token": ["Hyper-", "and", "C0020676#ent", "<e1>", "repercussions", "on", "C0702216#ent", "<e2>", ",", "nucleus", "and", "cytoplasm", "increases", "were", "studied", "by", "electron", "microscopy", "7-", ",", "14-", ",", "21-", ",", "and", "35-day-old", "rats", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0702216", "name": "C0702216#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "PTH", "responses", "to", "adrenaline", "(", "A", ")", "and", "C0020598#ent", "<e1>", "were", "studied", "with", "and", "without", "C0242889#ent", "<e2>", "phentolamine", "."], "h": {"id": "C0020598", "name": "C0020598#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "the", "early", "rate", "left", "ventricular", "diameter", "lengthening", "is", "increased", "in", "C0031048#ent", "<e1>", "of", "heart", "rate", "stroke", "volume", ",", "while", "the", "actual", "C2926735#ent", "<e2>", "of", "the", "rapid", "filling", "period", "is", "decreased", "."], "h": {"id": "C0031048", "name": "C0031048#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [23, 24]}}
{"token": ["During", "the", "intravenous", "infusion", "noradrenaline", "into", "spinal", "cats", "C0237795#ent", "<e1>", "responses", "to", "C0006168#ent", "<e2>", "and", "guanethidine", "were", "increased", ",", "whilst", "those", "to", "adrenaline", "and", "to", "noradrenaline", "were", "decreased", "."], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006168", "name": "C0006168#ent", "pos": [12, 13]}}
{"token": ["This", "is", "a", "case", "report", "an", "autopsy", "of", "a", "patient", "with", "systemic", "lupus", "erythematosus", "end", "stage", "renal", "disease", "C0085096#ent", "<e1>", "pancreatitis", ",", "and", "C0003509#ent", "<e2>", "."], "h": {"id": "C0085096", "name": "C0085096#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003509", "name": "C0003509#ent", "pos": [23, 24]}}
{"token": ["We", "show", "that", "C1705952#ent", "<e1>", "treatment", "causes", "reduced", "cell", "viability", "loss", "of", "nuclei", "integrity", "and", "C0025517#ent", "<e2>", "of", "the", "actin", "microfilament", "OCs", "."], "h": {"id": "C1705952", "name": "C1705952#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [15, 16]}}
{"token": ["This", "demonstrated", "that", "groES", "and", "C1415782#ent", "<e1>", "are", "in", "an", "C0022895#ent", "<e2>", "."], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [10, 11]}}
{"token": ["In", "the", "current", "study", ",", "we", "used", "transmission", "immune", "electron", "microscopy", "IEM", ")", "to", "visualize", "the", "cell", "surface", "both", "C2987364#ent", "<e1>", "(", "CAF2", ")", "and", "the", "C0659150#ent", "<e2>", "CHK21", ")", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0659150", "name": "C0659150#ent", "pos": [26, 27]}}
{"token": ["In", "other", "patients", ",", "it", "may", "be", "due", "to", "abnormal", "control", "of", "aquaporin-2", "water", "channels", "renal", "collecting", "tubules", "or", "production", "of", "an", "C0596110#ent", "<e1>", "principle", "other", "than", "C1334081#ent", "<e2>", "."], "h": {"id": "C0596110", "name": "C0596110#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1334081", "name": "C1334081#ent", "pos": [27, 28]}}
{"token": ["C2348358#ent", "<e1>", "antagonism", "also", "increased", "the", "expression", "of", "mitochondrial", "MnSOD", "C0024708#ent", "<e2>", "in", "DOCA-salt", "rats", "."], "h": {"id": "C2348358", "name": "C2348358#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024708", "name": "C0024708#ent", "pos": [10, 11]}}
{"token": ["L-5418", "may", "prove", "useful", "for", "C0014549#ent", "<e1>", "it", "is", "less", "toxic", "than", "C0237417#ent", "<e2>", "and", "carbamazepine", "."], "h": {"id": "C0014549", "name": "C0014549#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0237417", "name": "C0237417#ent", "pos": [12, 13]}}
{"token": ["In", "this", "way", ",", "C0081876#ent", "<e1>", "must", "be", "absorbed", "intact", "in", "the", "C0021831#ent", "<e2>", "which", "indicates", "that", "enteric", "drug", "delivery", "systems", "required", "for", "its", "oral", "administration"], "h": {"id": "C0081876", "name": "C0081876#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [12, 13]}}
{"token": ["The", "activity", "of", "this", "pathway", "is", "most", "evident", "in", "cells", "exposed", "to", "stimuli", "where", "the", "effects", "of", "C0043167#ent", "<e1>", "be", "blocked", "by", "inhibitors", "of", "tyrosine", "kinase", "C3541394#ent", "<e2>", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [26, 27]}}
{"token": ["We", "provide", "genetic", "evidence", "the", "production", "of", "C0001962#ent", "<e1>", "in", "tomato", "fruit", "regulated", "by", "pectin", "methylesterase", "C4283796#ent", "<e2>", ",", "EC", "3.1.1.11", ",", "an", "enzyme", "that", "catalyzes", "demethoxylation", "of", "pectins", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [16, 17]}}
{"token": ["In", "this", "assay", ",", "C0001962#ent", "<e1>", "produced", "by", "C4283796#ent", "<e2>", "hydrolysis", "of", "pectin", "methyl", "esters", "oxidized", "to", "formaldehyde", "by", "alcohol", "oxidase", "and", "the", "formaldehyde", "is", "continuously", "reacted", "with", "4-amino-3-penten-2-one", "to", "create", "a", "stable", ",", "fluorescent", "product"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [8, 9]}}
{"token": ["Our", "studies", "demonstrate", "an", "alternative", "mechanism", "for", "C1332080#ent", "<e1>", "involvement", "in", "the", "genesis", "of", "NHL", "and", "suggest", "that", "C3639960#ent", "<e2>", "activation", "results", "from", "ATIC-mediated", "homodimerization"], "h": {"id": "C1332080", "name": "C1332080#ent", "pos": [7, 8]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3639960", "name": "C3639960#ent", "pos": [18, 19]}}
{"token": ["An", "oncogenic", "role", "for", "C1442804#ent", "<e1>", "was", "shown", "after", "exposure", "of", "lines", "to", "C0003015#ent", "<e2>", "prevented", "C1442804#ent", "<e1>", "and", "Cbp/PAG", "phosphorylation", ",", "dissociated", "the", "signalosome", "from", "rafts", ",", "and", "eventually", "induced", "death", "."], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [13, 14]}}
{"token": ["The", "impact", "of", "two", "calcium", "channel", "blockers", "different", "structure", ",", "C0282138#ent", "<e1>", "and", "felodipine", ",", "on", "C1705340#ent", "<e2>", "secretion", "was", "studied", "under", "hyper-", "and", "hypocalcemic", "conditions", "."], "h": {"id": "C0282138", "name": "C0282138#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [16, 17]}}
{"token": ["West", "Nile", "virus", "cause", "a", "broad", "range", "of", "clinical", "syndromes", "including", "fever", ",", "meningitis", ",", "C0014060#ent", "<e1>", ",", "and", "a", "C0085620#ent", "<e2>", "of", "a", "poliomyelitis-like", "syndrome"], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085620", "name": "C0085620#ent", "pos": [20, 21]}}
{"token": ["C0033126#ent", "<e1>", "is", "an", "important", "C0003374#ent", "<e2>", "of", "its", "activity", "against", "exoerythrocytic", "forms", "of", "Plasmodium", "spp"], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [5, 6]}}
{"token": ["C0033126#ent", "<e1>", "and", "primaquine", ",", "the", "well", "known", "C0003374#ent", "<e2>", "8-aminoquinolines", ",", "have", "not", "been", "reported", "for", "their", "anticoccidial", "activity", "."], "h": {"id": "C0033126", "name": "C0033126#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [8, 9]}}
{"token": ["To", "analyze", "the", "mechanism", "of", "C1332729#ent", "<e1>", "homoassociation", ",", "the", "ectodomains", "C2826549#ent", "<e2>", "-", "5", "were", "connected", "by", "linker", "sequences", "the", "N", "terminus", "of", "the", "coiled-coil", "domain", "cartilage", "matrix", "protein", "CMP", ")", "."], "h": {"id": "C1332729", "name": "C1332729#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2826549", "name": "C2826549#ent", "pos": [11, 12]}}
{"token": ["A", "72-year-old", "woman", "with", "C0029408#ent", "<e1>", "of", "both", "hips", "and", "knees", "centrally", "dislocated", "hips", "during", "a", "C0014549#ent", "<e2>"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [16, 17]}}
{"token": ["A", "comparative", "analysis", "C0033640#ent", "<e1>", "encoded", "in", "the", "completely", "sequenced", "C0242965#ent", "<e2>", "of", "two", "plant", "species", ",", "namely", "Arabidopsis", "thaliana", "Oryza", "sativa", "spp", "japonica", "cv", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [10, 11]}}
{"token": ["There", "are", "closely", "related", "C0033640#ent", "<e1>", "both", "the", "Drosophila", "and", "Caenorhabditis", "elegans", "C0242965#ent", "<e2>", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [12, 13]}}
{"token": ["Candidates", "for", "drug", "therapy", "include", "those", "with", "familial", "hypercholesterolemia", "familial", "combined", "hyperlipidemia", "the", "C0524620#ent", "<e1>", "polycystic", "ovarian", "syndrome", "type", "1", "diabetes", "and", "the", "C0027726#ent", "<e2>"], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [23, 24]}}
{"token": ["In", "conclusion", ",", "we", "demonstrated", "that", "C3539739#ent", "<e1>", "induced", "dopamine", "release", "in", "a", "non-genomic", "manner", "through", "C1708136#ent", "<e2>", "N-type", "calcium", "channels"], "h": {"id": "C3539739", "name": "C3539739#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1708136", "name": "C1708136#ent", "pos": [16, 17]}}
{"token": ["Inhibitors", "of", "overall", "steroid", "synthesis", "WIN", "32,729", ")", ",", "prostaglandin", "synthesis", "meclofenamic", "acid", "indomethacin", ")", "and", "angiotensin", "converting", "enzyme", "C0006938#ent", "<e1>", ")", "and", "blockers", "of", "H1", "H2", "histamine", "receptors", "mepyramine", ",", "C0008783#ent", "<e2>", "or", "ranitidine", ")", "were", "without", "effect", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [31, 32]}}
{"token": ["An", "ala1", "disrupted", "allele", "demonstrated", "that", "the", "C0017337#ent", "<e1>", "is", "essential", "and", "that", ",", "therefore", ",", "C1413218#ent", "<e2>", "encodes", "an", "enzyme", "required", "for", "cytoplasmic", "protein", "synthesis"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413218", "name": "C1413218#ent", "pos": [16, 17]}}
{"token": ["The", "C2917660#ent", "<e1>", "composition", "resembles", "that", "of", "human", "C0003766#ent", "<e2>", "but", "differs", "markedly", "from", "that", "of", "porcine", "carboxypeptidase", "B.", "enzyme", "contains", "a", "mass", "fraction", "0.1", "carbohydrates", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003766", "name": "C0003766#ent", "pos": [8, 9]}}
{"token": ["The", "sequence", "shows", "no", "homology", "to", "any", "of", "the", "known", "sequences", "of", "C0391845#ent", "<e1>", "a", "35", "%", "identity", "to", "human", "C3710940#ent", "<e2>"], "h": {"id": "C0391845", "name": "C0391845#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3710940", "name": "C3710940#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "in", "the", "nucleus", "accumbens", "the", "olfactory", "tubercle", "the", "cellular", "localization", "C1708300#ent", "<e1>", "mRNA", "was", "investigated", "by", "determining", "the", "colocalization", "of", "C1708300#ent", "<e1>", "mRNA", "with", "C1418457#ent", "<e1>", "mRNA", "or", "dynorphin", "mRNA", "."], "h": {"id": "C1708300", "name": "C1708300#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418457", "name": "C1418457#ent", "pos": [26, 27]}}
{"token": ["Although", "epilepsy", "is", "very", "common", "in", "children", "with", "C0007789#ent", "<e1>", "these", "findings", "raise", "the", "possibility", "that", "C0004609#ent", "<e2>", "may", "potentiate", "seizures", "in", "certain", "young", "children", "with", "C0007789#ent", "<e1>"], "h": {"id": "C0007789", "name": "C0007789#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0004609", "name": "C0004609#ent", "pos": [16, 17]}}
{"token": ["C0149524#ent", "<e1>", "was", "not", "observed", "and", "C0033581#ent", "<e2>", "was", "absent", "in", "33", "(", "27", "benign", ",", "6", "malignant", ")", "."], "h": {"id": "C0149524", "name": "C0149524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [6, 7]}}
{"token": ["The", "most", "common", "causes", "of", "C0035067#ent", "<e1>", "atherosclerosis", "in", "647", "patients", ",", "C0027868#ent", "<e2>", "161", "patients", ",", "and", "renal", "artery", "aneurysm", "51", "patients", "."], "h": {"id": "C0035067", "name": "C0035067#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [12, 13]}}
{"token": ["We", "functionally", "identify", "40", "genes", "derepressed", "in", "human", "embryonic", "fibroblasts", "depleted", "of", "the", "PRC2", "components", "(", "EZH2", ",", "EED", ",", "C2347620#ent", "<e1>", ")", "and", "the", "C1418870#ent", "<e2>", "component", ",", "BMI-1", "."], "h": {"id": "C2347620", "name": "C2347620#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1418870", "name": "C1418870#ent", "pos": [25, 26]}}
{"token": ["Stimulation", "of", "the", "cerebellar", "fastigial", "nucleus", "FN", ")", "increases", "C1428360#ent", "<e1>", "but", "not", "metabolism", "and", "reduces", "the", "tissue", "damage", "from", "C0917798#ent", "<e2>"], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0917798", "name": "C0917798#ent", "pos": [20, 21]}}
{"token": ["C1705984#ent", "<e1>", ",", "placental", "alkaline", "phosphatase", "PLAP", ")", ",", "and", "epithelial", "membrane", "antigen", "C1705281#ent", "<e2>", ")", "were", "positive", "in", "6", "%", ",", "100", "%", ",", "and", "2", "%", "of", "cases", ",", "respectively", "."], "h": {"id": "C1705984", "name": "C1705984#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [13, 14]}}
{"token": ["Conversion", "of", "ceramide", ",", "a", "putative", "mediator", "of", "anticancer", "drug-induced", "apoptosis", ",", "into", "C1414998#ent", "<e1>", ",", "by", "the", "action", "of", "C0163410#ent", "<e2>", "GCS", ")", ",", "has", "been", "implicated", "in", "drug", "resistance"], "h": {"id": "C1414998", "name": "C1414998#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0163410", "name": "C0163410#ent", "pos": [20, 21]}}
{"token": ["Chronic", "intestinal", "pseudo-obstruction", "been", "associated", "with", "C0042075#ent", "<e1>", "myopathy", ",", "and", "ophthalmoplegia", "in", "adults", "and", "C0008350#ent", "<e2>", "in", "children", "."], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008350", "name": "C0008350#ent", "pos": [15, 16]}}
{"token": ["After", "3", "years", "of", "age", ",", "patients", "with", "C0342788#ent", "<e1>", "may", "present", "with", "cardiomyopathy", "and", "C0151786#ent", "<e2>"], "h": {"id": "C0342788", "name": "C0342788#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0151786", "name": "C0151786#ent", "pos": [15, 16]}}
{"token": ["Co-localization", "of", "C0208355#ent", "<e1>", "actin", "and", "C0027096#ent", "<e2>", "was", "found", "in", "the", "oocyte", "by", "double", "staining"], "h": {"id": "C0208355", "name": "C0208355#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [6, 7]}}
{"token": ["The", "most", "recently", "approved", "class", "of", "antiretrovirals", ",", "C3273483#ent", "<e1>", "have", "been", "associated", "with", "lipodystrophy", "syndrome", "hypersensitivity", "reactions", "C0042109#ent", "<e2>", ",", "morbilliform", "eruptions", "and", "a", "large", "number", "of", "drug", "interactions"], "h": {"id": "C3273483", "name": "C3273483#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [18, 19]}}
{"token": ["The", "C1333186#ent", "<e1>", "cysteine", "protease", "inhibitors", "target", "cysteine", "proteases", "as", "C0699919#ent", "<e2>", "been", "implicated", "in", "malignant", "progression"], "h": {"id": "C1333186", "name": "C1333186#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [10, 11]}}
{"token": ["Researchers", "can", "now", "ask", "whether", "a", "given", "C1254351#ent", "<e1>", "is", "likely", "to", "inhibit", "multiple", "drug", "resistance", "kill", "cells", "over-express", "specific", "C0037207#ent", "<e2>", "at", "the", "earliest", "phase", "of", "drug", "discovery"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037207", "name": "C0037207#ent", "pos": [20, 21]}}
{"token": ["This", "C1254351#ent", "<e1>", "also", "reverses", "malignant", "transformation", "to", "Platelet", "Derived", "Growth", "Factor", "K-fgf/hst", "C0037207#ent", "<e2>", "on", "this", "basis", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037207", "name": "C0037207#ent", "pos": [13, 14]}}
{"token": ["These", "pathological", "findings", "were", "distinct", "from", "those", "of", "C0343190#ent", "<e1>", "led", "to", "a", "diagnosis", "of", "C0031036#ent", "<e2>", "MPN", ")", "."], "h": {"id": "C0343190", "name": "C0343190#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0031036", "name": "C0031036#ent", "pos": [15, 16]}}
{"token": ["C0007971#ent", "<e1>", "a", "rare", "C0037274#ent", "<e2>", "has", "been", "seen", "in", "patients", "with", "emotional", "disturbances", "particularly", "in", "cases", "with", "neurotic", "and", "personality", "disorders"], "h": {"id": "C0007971", "name": "C0007971#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [4, 5]}}
{"token": ["The", "effects", "of", "four", "C0038766#ent", "<e1>", "(", "gliclazide", ",", "glibenclamide", ",", "C0008287#ent", "<e2>", "and", "glipizide", ")", "on", "insulin", "binding", "insulin", "action", "studied", "in", "vitro", "primary", "cultured", "rat", "hepatocytes", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0008287", "name": "C0008287#ent", "pos": [11, 12]}}
{"token": ["Treatment", "by", "C0010583#ent", "<e1>", "allowed", "a", "partial", "recovery", "or", "stabilization", "in", "patients", "with", "C0005956#ent", "<e2>", "(", "92", "%", ")", "or", "multiple", "mononeuropathy", "(", "100", "%", ")", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005956", "name": "C0005956#ent", "pos": [13, 14]}}
{"token": ["In", "two", "Russian", "studies", "(", "C1332415#ent", "<e1>", "and", "UTIAP-2", ")", "susceptibility", "to", "commonly", "used", "antimicrobial", "agents", "C0262655#ent", "<e2>", "UTI", ")", "was", "determined", "."], "h": {"id": "C1332415", "name": "C1332415#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0262655", "name": "C0262655#ent", "pos": [16, 17]}}
{"token": ["C0058133#ent", "<e1>", "dose-dependently", "inhibited", "the", "C0679408#ent", "<e2>", "formation", "by", "acidified", "aspirin", "and", "inhibited", "the", "decrease", "of", "gastric", "mucosal", "blood", "flow", "NDA-induced", "cirrhotic", "rats", "."], "h": {"id": "C0058133", "name": "C0058133#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0679408", "name": "C0679408#ent", "pos": [5, 6]}}
{"token": ["The", "genetic", "differences", "control", "elements", "MHC", "class", "II", "genes", "well", "contribute", "to", "differential", "immune", "reactivities", "and", "to", "C0021053#ent", "<e1>", "allergies", "or", "C0004364#ent", "<e2>"], "h": {"id": "C0021053", "name": "C0021053#ent", "pos": [17, 18]}, "relation": "nichd_parent_of", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [21, 22]}}
{"token": ["Seventy-eight", "patients", "with", "C0021053#ent", "<e1>", "38", "patients", "with", "C0004364#ent", "<e2>", "AD", ")", ",", "and", "40", "allergic", "patients", ")", "were", "included", "in", "the", "study", "."], "h": {"id": "C0021053", "name": "C0021053#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [8, 9]}}
{"token": ["The", "structural", "requirements", "recognition", "of", "peptidoglycan", "(", "C1420354#ent", "<e1>", ")", "by", "PGRP-LC", "and", "activation", "of", "the", "Drosophila", "C0004472#ent", "<e2>", "pathway", "are", "not", "yet", "clear", "."], "h": {"id": "C1420354", "name": "C1420354#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004472", "name": "C0004472#ent", "pos": [17, 18]}}
{"token": ["This", "was", "confirmed", "by", "the", "ability", "of", "excess", "recombinant", "C0123707#ent", "<e1>", "to", "inhibit", "the", "IGF-I", "and", "C0394006#ent", "<e2>", "-", "3", "]", "induced", "proteolysis", "of", "IGFBP-4", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0394006", "name": "C0394006#ent", "pos": [16, 17]}}
{"token": ["The", "patients", "were", "females", "aged", "15", ",", "16", ",", "and", "25", "years", "with", "histories", "of", "various", "C0035204#ent", "<e1>", "extrinsic", "asthma", "recurrent", "pneumonias", ",", "and", "C0032326#ent", "<e2>", ")", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0032326", "name": "C0032326#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "possible", "injury", "mechanisms", "in", "the", "C0235267#ent", "<e1>", "of", "elderly", "individuals", "and", "the", "effects", "of", "C0162298#ent", "<e2>", "model", "outputs", "indicative", "of", "injury", "as", "a", "function", "of", "age", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162298", "name": "C0162298#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "absence", "of", "C1332667#ent", "<e1>", "high", "expression", "of", "C1417925#ent", "<e2>", "constitute", "two", "levels", "of", "protection", "from", "apoptosis", "induced", "by", "DRs", "and", "inflammatory", "cytokines", "neural", "stem", "progenitor", "cells"], "h": {"id": "C1332667", "name": "C1332667#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417925", "name": "C1417925#ent", "pos": [9, 10]}}
{"token": ["There", "is", "sparse", "data", "in", "C3889248#ent", "<e1>", "patients", "without", "C0426576#ent", "<e2>"], "h": {"id": "C3889248", "name": "C3889248#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [9, 10]}}
{"token": ["Finally", ",", "we", "show", "that", "C1414639#ent", "<e1>", "and", "NOT5", "can", "be", "immunoprecipitated", "by", "C0077021#ent", "<e2>", "."], "h": {"id": "C1414639", "name": "C1414639#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0077021", "name": "C0077021#ent", "pos": [13, 14]}}
{"token": ["Among", "1500", "patients", "in", "the", "reproductive", "age", "Clinical", "Department", "Endocrinological", "Gynecology", "State", "Hospital", "Warszawa", ",", "Poland", "estimated", "the", "correlations", "between", "the", "onset", "of", "C1332629#ent", "<e1>", "BBD", ")", "and", "the", "incidence", "of", "C0302280#ent", "<e2>"], "h": {"id": "C1332629", "name": "C1332629#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0302280", "name": "C0302280#ent", "pos": [31, 32]}}
{"token": ["Surveys", "investigating", "the", "occurrence", "of", "C0013447#ent", "<e1>", "related", "environmental", "factors", "15", "other", "institutions", "that", "house", "okapi", "revealed", "C0699744#ent", "<e2>", "was", "only", "seen", "at", "one", "institution", "."], "h": {"id": "C0013447", "name": "C0013447#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0699744", "name": "C0699744#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "antibodies", "raised", "in", "rabbits", "against", "rat", "kidney", "aminopeptidase", "M", "inhibited", "the", "aminopeptidase", "activities", "both", "kidney", "and", "brain", "puromycin-insensitive", "C3540017#ent", "<e1>", "at", "similar", "dilutions", ",", "while", "the", "C1417779#ent", "<e2>", "was", "not", "affected", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1417779", "name": "C1417779#ent", "pos": [28, 29]}}
{"token": ["Although", "new", "formulations", "have", "been", "developed", "for", "treatment", "of", "C0026946#ent", "<e1>", "infants", ",", "amphotericin", "B", "first-line", "treatment", "systemic", "C0006840#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [18, 19]}}
{"token": ["The", "most", "prevalent", "C0026946#ent", "<e1>", "humans", "is", "C0006840#ent", "<e2>", "which", "is", "caused", "by", "species", "of", "Candida", "that", "are", "typical", "members", "of", "the", "commensal", "microbial", "flora", "of", "the", "oral", "mucosa", "other", "body", "surfaces"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [7, 8]}}
{"token": ["Peptide", "mapping", "the", "fragments", "obtained", "by", "incubation", "of", "C0907533#ent", "<e1>", "and", "secreted", "conglutin", "gamma", "with", "C0041236#ent", "<e2>", "and", "pepsin", "revealed", "no", "difference", "between", "the", "two", "proteins", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [15, 16]}}
{"token": ["C0242350#ent", "<e1>", "in", "hypertensive", "men", "on", "treatment", "with", "C0025741#ent", "<e2>", "can", "not", "be", "explained", "by", "abnormalities", "in", "secretion", "of", "the", "reproductive", "hormones"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025741", "name": "C0025741#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "further", "positive", "inotropic", "effects", "be", "expected", "when", "digitalis", "is", "given", "to", "patients", "with", "C0018802#ent", "<e1>", "are", "already", "optimally", "treated", "with", "C0600487#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0600487", "name": "C0600487#ent", "pos": [23, 24]}}
{"token": ["NR", "function", "well", "as", "calpain", "activity", "was", "not", "affected", "in", "cultures", "concomitantly", "treated", "with", "C0071766#ent", "<e1>", "either", "TTX", "or", "a", "NR", "antagonist", "CGS19755", "(", "C0285608#ent", "<e2>", ")", "or", "memantine", ")", "."], "h": {"id": "C0071766", "name": "C0071766#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0285608", "name": "C0285608#ent", "pos": [24, 25]}}
{"token": ["There", "was", "no", "correlation", "between", "C1334533#ent", "<e1>", "or", "SEF", "and", "sedation", "score", "blood", "concentration", "C1254351#ent", "<e2>", "."], "h": {"id": "C1334533", "name": "C1334533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["Although", "GVBD", "was", "induced", "by", "C1334533#ent", "<e1>", "in", "the", "presence", "of", "cytochalasin", "D", "this", "C1254351#ent", "<e2>", "prevented", "MPF-induced", "FEBD", ",", "and", "each", "follicular", "cell", "in", "situ", "the", "surface", "of", "the", "oocyte", "."], "h": {"id": "C1334533", "name": "C1334533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["Carcinogenic", "potencies", "C1416894#ent", "<e1>", "and", "BaP", "in", "C1418251#ent", "<e2>", "mixtures", "based", "on", "TEF", "concept", "were", "45", "%", "and", "39", "%", "respectively", "."], "h": {"id": "C1416894", "name": "C1416894#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418251", "name": "C1418251#ent", "pos": [7, 8]}}
{"token": ["It", "seems", "likely", "that", "C3a", "generated", "in", "the", "course", "of", "C0032285#ent", "<e1>", "contribute", "to", "the", "mucus", "secretion", "associated", "with", "C0024116#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024116", "name": "C0024116#ent", "pos": [19, 20]}}
{"token": ["She", "was", "seropositive", "for", "CMV", "before", "undergoing", "APBSCT", "and", "had", "required", "prednisone", "for", "immune", "thrombocytopenia", "C0162820#ent", "<e1>", "9", "weeks", "prior", "to", "the", "onset", "of", "C0032285#ent", "<e2>", "."], "h": {"id": "C0162820", "name": "C0162820#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [24, 25]}}
{"token": ["The", "C0524926#ent", "<e1>", "eNOS", "and", "C0907533#ent", "<e2>", "were", "expressed", "by", ">", "50", "%", "of", "osteonal", "osteocytes", "in", "controls", "."], "h": {"id": "C0524926", "name": "C0524926#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}}
{"token": ["C0263409#ent", "<e1>", "or", "localized", "scleroderma", "a", "C0029400#ent", "<e2>", "still", "unknown", "aetiology", "."], "h": {"id": "C0263409", "name": "C0263409#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029400", "name": "C0029400#ent", "pos": [6, 7]}}
{"token": ["The", "authors", "report", "on", "the", "pathological", "findings", "and", "contents", "of", "various", "C0038317#ent", "<e1>", "in", "the", "adenomas", "of", "three", "cases", "of", "C0010481#ent", "<e2>"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [20, 21]}}
{"token": ["The", "content", "of", "gonadotropic", "hormones", "prolactin", "and", "C0038317#ent", "<e1>", "examined", "in", "the", "blood", "of", "97", "women", "with", "C0010481#ent", "<e2>", "and", "after", "administration", "of", "LH-RH", "and", "chorionic", "gonadotropin", "hormone"], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [17, 18]}}
{"token": ["C0038317#ent", "<e1>", "drops", "can", "produce", "iatrogenic", "C0010481#ent", "<e2>", "the", "recommended", "dose", "exceeded", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0010481", "name": "C0010481#ent", "pos": [6, 7]}}
{"token": ["In", "this", "study", ",", "C0162429#ent", "<e1>", "increased", "resistance", "to", "C0027867#ent", "<e2>", "sensitivity", "to", "SCh", "compared", "with", "the", "control", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027867", "name": "C0027867#ent", "pos": [9, 10]}}
{"token": ["We", "also", "observed", "that", "the", "12", "non-proband", "C2676232#ent", "<e1>", "siblings", "included", "only", "four", "with", "a", "history", "suggestive", "of", "C0025303#ent", "<e2>", "and", "thus", "C2676232#ent", "<e1>", "individuals", "apparently", "differ", "in", "susceptibility", "to", "Neisseria", "meningitidis", "infection"], "h": {"id": "C0025303", "name": "C0025303#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2676232", "name": "C2676232#ent", "pos": [7, 8]}}
{"token": ["The", "treatment", "for", "C0017925#ent", "<e1>", "the", "use", "of", "systemic", "steroids", "immunosuppressive", "drugs", "the", "C0041044#ent", "<e2>", "radiotherapy", "associated", "with", "chemotherapy", "appears", "most", "effective", "in", "Stewart's", "disease"], "h": {"id": "C0017925", "name": "C0017925#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "all", "tumour-bearing", "animals", "were", "clearly", "C0020557#ent", "<e1>", "(", "80", "%", "increase", "in", "circulating", "C0017860#ent", "<e2>", "in", "wild-type", "and", "36", "%", "in", "knockout", "mice", "."], "h": {"id": "C0020557", "name": "C0020557#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [16, 17]}}
{"token": ["The", "ratio", "was", "markedly", "decreased", "in", "all", "cases", "of", "C0043459#ent", "<e1>", "and", "in", "three", "of", "the", "four", "cases", "of", "neonatal", "C0162309#ent", "<e2>", ",", "whereas", "it", "was", "normal", "in", "the", "X-linked", "cases", "."], "h": {"id": "C0043459", "name": "C0043459#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0162309", "name": "C0162309#ent", "pos": [20, 21]}}
{"token": ["It", "has", "been", "proposed", "that", "phosphoinositide", "3-kinase", "C1709402#ent", "<e1>", ",", "one", "of", "the", "C2936824#ent", "<e2>", "can", "be", "regulated", "by", "G-protein-coupled", "receptor", "well", "as", "nerve", "growth", "factor-associated", "receptors"], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [13, 14]}}
{"token": ["The", "ability", "of", "Mn2", "+", "ions", "to", "confer", "bypass", "of", "bulky", "lesions", "was", "not", "observed", "with", "other", "C0012892#ent", "<e1>", "the", "B", "family", "such", "as", "bacteriophage", "T4", "C0012890#ent", "<e2>"], "h": {"id": "C0012892", "name": "C0012892#ent", "pos": [17, 18]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0012890", "name": "C0012890#ent", "pos": [26, 27]}}
{"token": ["Other", "ATPases", ",", "including", "C0018437#ent", "<e1>", "sarcolemmal", "Na+-K+", "ATPase", ",", "and", "C2678065#ent", "<e2>", "were", "not", "inhibited", "by", "this", "agent", "."], "h": {"id": "C0018437", "name": "C0018437#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2678065", "name": "C2678065#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "the", "molecular", "mechanisms", "for", "the", "regulation", "of", "C1332826#ent", "<e1>", "between", "humans", "and", "cynomolgus", "monkeys", "although", "the", "regulatory", "mechanisms", "CYP1A1", "and", "C3814396#ent", "<e2>", "similar", "."], "h": {"id": "C1332826", "name": "C1332826#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3814396", "name": "C3814396#ent", "pos": [24, 25]}}
{"token": ["Corticotropin-releasing", "factor", "C1538975#ent", "<e1>", ")", "is", "a", "candidate", "for", "mediating", "the", "C0003123#ent", "<e2>", "alpha-MSH", "."], "h": {"id": "C1538975", "name": "C1538975#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003123", "name": "C0003123#ent", "pos": [11, 12]}}
{"token": ["C0965129#ent", "<e1>", "competitively", "inhibited", "the", "uptake", "of", "C0085542#ent", "<e2>", ",", "with", "an", "inhibition", "constant", "K(i", ")", ")", "(", "2.75", "micro", "M", "relatively", "similar", "to", "its", "K(m", ")", "."], "h": {"id": "C0965129", "name": "C0965129#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085542", "name": "C0085542#ent", "pos": [7, 8]}}
{"token": ["C0524892#ent", "<e1>", "gene", "rearrangements", "occurred", "on", "both", "C0002085#ent", "<e2>", "(", "65", "%", "of", "cases", ")", "and", "in", "approximately", "70", "%", "concerned", "rearrangements", "to", "Jgamma1", "gene", "segments"], "h": {"id": "C0524892", "name": "C0524892#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [7, 8]}}
{"token": ["Acyclovir", "is", "licensed", "for", "treatment", "of", "C0008049#ent", "<e1>", "and", "herpes", "zoster", "and", "acyclovir", ",", "C0249458#ent", "<e2>", ",", "and", "famciclovir", "are", "approved", "for", "herpes", "zoster"], "h": {"id": "C0008049", "name": "C0008049#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0249458", "name": "C0249458#ent", "pos": [14, 15]}}
{"token": ["Search", "for", "possible", "causes", "of", "this", "high", "incidence", "of", "myocardial", "infarcts", "several", "unique", "features", "of", "this", "mouse", ":", "hypertension", ",", "C3277671#ent", "<e1>", ",", "and", "early", "onset", "circulating", "immune", "complexes", "C0017658#ent", "<e2>", "."], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [29, 30]}}
{"token": ["The", "subunit", "composition", "of", "the", "isoenzymes", ",", "as", "well", "as", "the", "similarities", "to", "human", "C0005270#ent", "<e1>", ",", "were", "determined", "by", "using", "the", "specific", "C0887847#ent", "<e2>", "substrate", "4-methylumbelliferyl-beta-N-acetylglucosamine-6-sulphate"], "h": {"id": "C0005270", "name": "C0005270#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0887847", "name": "C0887847#ent", "pos": [23, 24]}}
{"token": ["Five", "patients", "with", "borderline", "personality", "disorder", "BPD", ")", "and", "5", "patients", "with", "schizotypal", "personality", "disorder", "(", "C3273505#ent", "<e1>", ")", "completed", "at", "least", "3", "weeks", "of", "treatment", "with", "C0002644#ent", "<e2>", "."], "h": {"id": "C3273505", "name": "C3273505#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002644", "name": "C0002644#ent", "pos": [27, 28]}}
{"token": ["The", "effects", "of", "C0006938#ent", "<e1>", "and", "of", "other", "angiotensin-converting", "enzyme", "inhibitors", "C0078836#ent", "<e2>", ",", "fosenopril", "and", "enalaprilic", "acid", "were", "tested", "on", "the", "isolated", "rabbit", "heart", "aorta", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0078836", "name": "C0078836#ent", "pos": [11, 12]}}
{"token": ["No", "such", "changes", "were", "found", "in", "other", "C3273406#ent", "<e1>", "patients", "with", "chronic", "pyelonephritis", "C0022661#ent", "<e2>", "exacerbation", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [13, 14]}}
{"token": ["C0268731#ent", "<e1>", "to", "perfusion", "(", "C4053934#ent", "<e2>", "was", "present", "in", "4", "cases", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C4053934", "name": "C4053934#ent", "pos": [5, 6]}}
{"token": ["Macrophage", "migration", "inhibitory", "factor", "C1334507#ent", "<e1>", ")", ",", "an", "immunoregulatory", "protein", "exhibits", "a", "C1870471#ent", "<e2>", "PPT", ")", "activity", "."], "h": {"id": "C1334507", "name": "C1334507#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1870471", "name": "C1870471#ent", "pos": [13, 14]}}
{"token": ["The", "treatment", "of", "C0030086#ent", "<e1>", "compounds", "2a-c", "gave", ",", "regioselectively", ",", "C0014994#ent", "<e2>", "alpha-(1H-pyrazolo[3,4-d]pyrimidin-4-yl)thioalkylates", "3a-c", ",", "respectively", "."], "h": {"id": "C0030086", "name": "C0030086#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014994", "name": "C0014994#ent", "pos": [11, 12]}}
{"token": ["The", "newer", "oral", "antifungal", "agents", "the", "treatment", "of", "C0040261#ent", "<e1>", "in", "children", "include", "itraconazole", ",", "C0076110#ent", "<e2>", ",", "and", "fluconazole", "."], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [15, 16]}}
{"token": ["attenuated", "the", "inhibition", "of", "eosinophilia", "by", "C0073561#ent", "<e1>", "but", "had", "no", "effect", "the", "inhibition", "of", "AHR", "to", "C0600370#ent", "<e2>", "in", "OVA", "challenged", "mice", "."], "h": {"id": "C0073561", "name": "C0073561#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [17, 18]}}
{"token": ["had", "no", "effect", "the", "inhibition", "of", "eosinophilia", "by", "C0073561#ent", "<e1>", "but", "attenuated", "the", "inhibition", "of", "AHR", "to", "C0600370#ent", "<e2>", "in", "OVA", "challenged", "mice", "."], "h": {"id": "C0073561", "name": "C0073561#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [17, 18]}}
{"token": ["A", "44-year-old", "man", "diagnosed", "of", "common", "variable", "immunodeficiency", "associated", "with", "C0040034#ent", "<e1>", "due", "to", "autoimmunity", "required", "anesthesia", "for", "C0016167#ent", "<e2>", "hemorrhoidectomy", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0016167", "name": "C0016167#ent", "pos": [18, 19]}}
{"token": ["The", "association", "is", "specific", ",", "since", "C1336694#ent", "<e1>", "does", "not", "copatch", "with", "other", "tyrosine", "kinase", "receptors", "including", "C1334909#ent", "<e2>", ",", "platelet-derived", "growth", "factor", "receptor-beta", "and", "Torso", "(Tor", "."], "h": {"id": "C1336694", "name": "C1336694#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334909", "name": "C1334909#ent", "pos": [17, 18]}}
{"token": ["Other", "newer", "factors", "which", "have", "emerged", "include", "folate", "deficiency", "low", "HDL-cholesterol", ",", "insulin", "resistance", "abdominal", "obesity", "C0066357#ent", "<e1>", "Angiotensin", "Converting", "C1333402#ent", "<e2>", "polymorphism", "."], "h": {"id": "C0066357", "name": "C0066357#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [20, 21]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "study", "the", "effect", "of", "C0014027#ent", "<e1>", "(", "E", ")", "on", "left", "ventricular", "(LV)", "mass", "LV", "function", "blood", "renin-angiotensin", "C0003873#ent", "<e2>", ")", "in", "patients", "with", "hypertension", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [25, 26]}}
{"token": ["Subclinical", "form", "of", "C0020676#ent", "<e1>", "was", "not", "associated", "with", "changes", "in", "C0001477#ent", "<e2>", "content", "in", "osteoblasts", "and", "blood", "plasma", "in", "the", "content", "of", "ATP", "and", "prostaglandin", "E2"], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [11, 12]}}
{"token": ["Tropical", "spastic", "paraparesis", "the", "C0005956#ent", "<e1>", "and", ",", "perhaps", ",", "an", "MS-like", "C0019537#ent", "<e2>", "may", "represent", "clinical", "variants", "the", "same", "disease", ",", "a", "retroviral", "myelopathy"], "h": {"id": "C0005956", "name": "C0005956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019537", "name": "C0019537#ent", "pos": [12, 13]}}
{"token": ["In", "osteoclast", "precursor", "cells", "FcRgamma", "and", "C1705703#ent", "<e1>", "associate", "with", "multiple", "immunoreceptors", "and", "activate", "calcium", "signalling", "C1418640#ent", "<e2>"], "h": {"id": "C1705703", "name": "C1705703#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418640", "name": "C1418640#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "pig", "folylpoly-gamma-carboxypeptidase", "rat", "C1333570#ent", "<e1>", "and", "human", "C1310550#ent", "<e2>", "to", "represent", "varied", "expressions", "of", "the", "same", "gene", "in", "different", "species", "and", "tissues", "."], "h": {"id": "C1333570", "name": "C1333570#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1310550", "name": "C1310550#ent", "pos": [9, 10]}}
{"token": ["Prostate", "specific", "membrane", "antigen", "C1333570#ent", "<e1>", ")", ",", "also", "known", "as", "C1310550#ent", "<e2>", "FOLH1", ")", ",", "is", "a", "100", "kDa", "glycoprotein", "with", "elevated", "expression", "in", "prostate", "epithelial", "tissue", "."], "h": {"id": "C1333570", "name": "C1333570#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1310550", "name": "C1310550#ent", "pos": [11, 12]}}
{"token": ["After", "estradiol", "treatment", "the", "increase", "of", "IP(3", ")", "production", ",", "prevented", "by", "C0014930#ent", "<e1>", "or", "by", "C0031671#ent", "<e2>", "PLC", ")", "inhibitor", "(", "neomycin", ")", ",", "was", "present", "in", "MCF7", "cells"], "h": {"id": "C0014930", "name": "C0014930#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [16, 17]}}
{"token": ["Further", "development", "of", "a", "Delta(9)-THC", "MDI", "could", "provide", "an", "appropriate", "delivery", "device", "the", "therapeutic", "use", "of", "C2347556#ent", "<e1>", ",", "thereby", "reducing", "the", "need", "for", "C0024808#ent", "<e2>"], "h": {"id": "C2347556", "name": "C2347556#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0024808", "name": "C0024808#ent", "pos": [24, 25]}}
{"token": ["C2347556#ent", "<e1>", "CBD", ",", "a", "non-psychoactive", "constituent", "of", "C0024808#ent", "<e2>", ",", "has", "been", "reported", "to", "possess", "essentially", "no", "affinity", "for", "cannabinoid", "CB1", "receptor", "binding", "sites", "the", "brain", "."], "h": {"id": "C2347556", "name": "C2347556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024808", "name": "C0024808#ent", "pos": [8, 9]}}
{"token": ["We", "show", "that", "C3274819#ent", "<e1>", "null", "mutants", "twice", "as", "many", "C1708004#ent", "<e2>", "neurons", "relative", "to", "wildtypes", "at", "E15", ",", "but", "by", "birth", "have", "half", "the", "number", "of", "Me5", "cells", "as", "wildtypes", "."], "h": {"id": "C3274819", "name": "C3274819#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1708004", "name": "C1708004#ent", "pos": [10, 11]}}
{"token": ["The", "involvement", "of", "C1706586#ent", "<e1>", "in", "the", "C1710463#ent", "<e2>", "the", "hypertrophic", "chondrocyte-specific", "collagen", "X", "gene", "investigated", "using", "cotransfections", "of", "collagen", "X", "reporter", "plasmids", "and", "expression", "vectors", "mutant", "c-Raf", "proteins"], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [7, 8]}}
{"token": ["Another", "poor-grade", "patient", "(", "C0062941#ent", "<e1>", "surgery", ")", "with", "bilateral", "large", "C0917996#ent", "<e2>", "a", "large", "intracerebral", "haematoma", "a", "pontine", "angle", "meningioma", "with", "dysphasia", "and", "short-memory", "dysfunction"], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0917996", "name": "C0917996#ent", "pos": [11, 12]}}
{"token": ["We", "discuss", "possible", "predisposing", "factors", "C0028271#ent", "<e1>", "as", "malnutrition", ",", "C0005943#ent", "<e2>", "HIV", "infection", "and", "immune", "compromise", "."], "h": {"id": "C0028271", "name": "C0028271#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [10, 11]}}
{"token": ["In", "placenta", "membranes", "newborn", "girls", "carrying", "electrophoretically", "distinguishable", "C2939465#ent", "<e1>", "alleles", ",", "the", "maternally", "derived", "C0022173#ent", "<e2>", "is", "expressed", "preferentially", "."], "h": {"id": "C2939465", "name": "C2939465#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [15, 16]}}
{"token": ["C3539609#ent", "<e1>", ",", "but", "not", "other", "C1413968#ent", "<e2>", "blocked", "the", "DNA", "binding", "activity", "Stat1", "and", "inhibited", "Stat1-mediated", "gene", "activation", "in", "response", "to", "interferon", "."], "h": {"id": "C3539609", "name": "C3539609#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413968", "name": "C1413968#ent", "pos": [6, 7]}}
{"token": ["ARIP3", "enhances", "glucocorticoid", "receptor-dependent", "transcription", "more", "efficiently", "than", "Miz1", "or", "C3539609#ent", "<e1>", ",", "and", "all", "C1413968#ent", "<e2>", "proteins", "also", "activate", "estrogen", "receptor-", "progesterone", "receptor-dependent", "transcription", "but", "to", "a", "dissimilar", "degree", "."], "h": {"id": "C3539609", "name": "C3539609#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413968", "name": "C1413968#ent", "pos": [15, 16]}}
{"token": ["CHO-Adrr", "cells", "expressed", "a", "4-fold", "reduced", "level", "of", "C0012863#ent", "<e1>", "overexpressed", "an", "alpha", "class", "basic", ")", "C1415329#ent", "<e2>", "GST", ")", "."], "h": {"id": "C0012863", "name": "C0012863#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415329", "name": "C1415329#ent", "pos": [16, 17]}}
{"token": ["In", "this", "review", ",", "these", "novel", "differentially", "regulated", "C0017337#ent", "<e1>", "that", "respond", "to", "C1321567#ent", "<e2>", "stress", "are", "described", ",", "and", "they", "may", "serve", "as", "possible", "targets", "for", "gene", "therapy", "the", "treatment", "of", "diabetic", "nephropathy"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1321567", "name": "C1321567#ent", "pos": [13, 14]}}
{"token": ["The", "C0304713#ent", "<e1>", "with", "its", "specific", "C0038760#ent", "<e2>", "intact", ",", "labeled", "cells", "at", "concentrations", "as", "low", "as", "10(-9", ")", "M", ",", "with", "a", "minimal", "loading", "time", "5", "min", "."], "h": {"id": "C0304713", "name": "C0304713#ent", "pos": [1, 2]}, "relation": "has_chemical_structure", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [6, 7]}}
{"token": ["Phosphorylation", "of", "C3538729#ent", "<e1>", "at", "these", "sites", "was", "essential", "for", "its", "interaction", "with", "C3274761#ent", "<e2>", "for", "export", "to", "the", "cytosol", ",", "whereas", "nuclear", "import", "C3538729#ent", "<e1>", "requires", "dephosphorylated", "C3538729#ent", "<e1>", "to", "interact", "with", "importin", "alpha"], "h": {"id": "C3538729", "name": "C3538729#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3274761", "name": "C3274761#ent", "pos": [13, 14]}}
{"token": ["The", "prevalence", "of", "C0029453#ent", "<e1>", "and", "osteoporosis", "in", "young", "adults", "C0342788#ent", "<e2>", "is", "extremely", "high", "."], "h": {"id": "C0029453", "name": "C0029453#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0342788", "name": "C0342788#ent", "pos": [10, 11]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "evaluate", "the", "level", "of", "lipid", "peroxidation", "by", "measuring", "malondialdehyde", ")", "and", "C0633225#ent", "<e1>", "ceruloplasmin", ",", "glutathione", ",", "superoxide", "dismutase", "in", "C0010054#ent", "<e2>"], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [26, 27]}}
{"token": ["The", "C0030196#ent", "<e1>", "characterized", "were", "the", "preparations", "of", "C0002272#ent", "<e2>", ",", "biospecificaly", "adsorbed", "on", "concanavalin", "A", "conjugated", "to", "activated", "bead", "cellulose"], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [8, 9]}}
{"token": ["Transplantation", "of", "bone", "marrow", "cells", "C2985251#ent", "<e1>", "null", "mice", "some", "of", "the", "symptoms", "including", "C0037284#ent", "<e2>", "bodyweight", "loss", "in", "the", "recipient", "mice"], "h": {"id": "C2985251", "name": "C2985251#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [14, 15]}}
{"token": ["Following", "surgery", "for", "a", "chronic", "subdural", "haematoma", "a", "74-year-old", "patient", "received", "C0244656#ent", "<e1>", "as", "prophylaxis", "for", "C0014544#ent", "<e2>", "."], "h": {"id": "C0244656", "name": "C0244656#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [16, 17]}}
{"token": ["The", "general", "C3539645#ent", "<e1>", "inhibitor", "GF109203X", "reversed", "the", "effect", "of", "C0246694#ent", "<e2>", ",", "indicating", "that", "the", "prolonged", "TPA-induced", "inhibition", "of", "GJIC", "caused", "by", "C0246694#ent", "<e2>", "was", "due", "to", "the", "prolonged", "C3539645#ent", "<e1>", "activity", "."], "h": {"id": "C0246694", "name": "C0246694#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [2, 3]}}
{"token": ["Accordingly", ",", "the", "use", "of", "sildenafil", ",", "a", "C1318700#ent", "<e1>", "inhibitor", ",", "has", "been", "studied", "in", "relation", "to", "C1997362#ent", "<e2>", "female", "sexual", "dysfunction"], "h": {"id": "C1318700", "name": "C1318700#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1997362", "name": "C1997362#ent", "pos": [18, 19]}}
{"token": ["After", "activation", ",", "T", "cells", "CD45R", "and", "acquire", "a", "high", "density", "of", "C1870006#ent", "<e1>", "p180", "and", "of", "C2346901#ent", "<e2>", "."], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2346901", "name": "C2346901#ent", "pos": [17, 18]}}
{"token": ["The", "expression", "of", "C1870006#ent", "<e1>", "isoforms", "and", "of", "C2346901#ent", "<e2>", "has", "been", "analyzed", "as", "a", "function", "of", "time", "by", "correlating", "cell", "surface", "phenotype", "with", "mRNA", "synthesis"], "h": {"id": "C1870006", "name": "C1870006#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2346901", "name": "C2346901#ent", "pos": [8, 9]}}
{"token": ["The", "C3541394#ent", "<e1>", "of", "the", "non-mevalonate", "pathway", "C0020823#ent", "<e2>", "synthesis", ",", "which", "is", "unique", "to", "many", "pathogenic", "bacteria", ",", "have", "recently", "been", "explored", "as", "targets", "for", "antibiotic", "development"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [7, 8]}}
{"token": ["This", "enzyme", "possesses", "site-specific", "endonuclease", "C0001473#ent", "<e1>", ",", "and", "DNA", "strand", "separation", "(", "\"", "C0920283#ent", "<e2>", "\"", ")", "catalytic", "activities", "which", "work", "in", "concert", "to", "excise", "and", "package", "a", "single", "viral", "genome", "phage", "assembly"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0920283", "name": "C0920283#ent", "pos": [14, 15]}}
{"token": ["It", "is", "an", "C0001473#ent", "<e1>", "and", "a", "C0920283#ent", "<e2>", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0920283", "name": "C0920283#ent", "pos": [7, 8]}}
{"token": ["Our", "results", "demonstrated", "that", "C1860224#ent", "<e1>", "from", "patients", "with", "C0036203#ent", "<e2>", "released", "significantly", "increased", "levels", "of", "IV-Case", "with", "respect", "to", "patients", "with", "inactive", "disease", "control", "subjects"], "h": {"id": "C1860224", "name": "C1860224#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036203", "name": "C0036203#ent", "pos": [9, 10]}}
{"token": ["In", "C0867389#ent", "<e1>", "GvHD", ")", "in", "mice", ",", "a", "model", "for", "human", "C0024143#ent", "<e2>", "the", "end-stage", "sclerotic", "lesions", "were", "previously", "shown", "to", "contain", "large", "amounts", "of", "fibronectin", "(", "FN", ")", "."], "h": {"id": "C0867389", "name": "C0867389#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [12, 13]}}
{"token": ["The", "influence", "of", "cyclosporine", "A", "CsA", ")", "treatment", "on", "the", "development", "of", "glomerulonephritis", "and", "glomerulosclerosis", "was", "investigated", "in", "C0867389#ent", "<e1>", "GvHD", ")", ",", "a", "murine", "model", "for", "C0024143#ent", "<e2>"], "h": {"id": "C0867389", "name": "C0867389#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [27, 28]}}
{"token": ["The", "LD50", "for", "rubratoxin", "B", "in", "C0012403#ent", "<e1>", "and", "administered", "to", "ICR", "mice", "C1419070#ent", "<e2>", "injection", "was", "0.31", "(", "0.22", "-", "0.43", ")", "mg/kg", "body", "weight"], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419070", "name": "C1419070#ent", "pos": [13, 14]}}
{"token": ["The", "LD50", "for", "rubratoxin", "B", "in", "C0012403#ent", "<e1>", "and", "administered", "to", "Mongolian", "gerbils", "C1419070#ent", "<e2>", "injection", "was", "2.0", "(", "2.26", "-", "1.77", ")", "mg/kg", "body", "weight"], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419070", "name": "C1419070#ent", "pos": [13, 14]}}
{"token": ["C0015458#ent", "<e1>", "then", "converts", "coagulation", "factor", "XI", "C0015527#ent", "<e2>", "XIa", ")", "and", "prekallikrein", "to", "kallikrein", "."], "h": {"id": "C0015458", "name": "C0015458#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015527", "name": "C0015527#ent", "pos": [7, 8]}}
{"token": ["Candidate", "regions", "for", "the", "design", "of", "a", "primer", "were", "identified", "as", "those", "having", "the", "least", "number", "of", "C2917660#ent", "<e1>", "nucleotide", "sequence", "variants", "among", "the", "different", "C1419141#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1419141", "name": "C1419141#ent", "pos": [25, 26]}}
{"token": ["A", "6-year-old", "boy", "with", "the", "severe", "form", "of", "the", "C0242597#ent", "<e1>", "LAD", ")", "received", "a", "transplant", "of", "cord", "blood", "C0155017#ent", "<e2>", ")", "from", "his", "HLA-identical", "brother", "."], "h": {"id": "C0242597", "name": "C0242597#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0155017", "name": "C0155017#ent", "pos": [19, 20]}}
{"token": ["These", "observations", "collectively", "suggest", "that", "C2987236#ent", "<e1>", "is", "a", "C1424988#ent", "<e2>", "facilitates", "the", "function", "of", "at", "least", "one", "member", "of", "the", "cytohesin/ARNO", "family", "in", "response", "to", "specific", "cellular", "stimuli"], "h": {"id": "C2987236", "name": "C2987236#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424988", "name": "C1424988#ent", "pos": [9, 10]}}
{"token": ["The", "structural", "integrity", "serum", "proteins", "albumin", ",", "C3536873#ent", "<e1>", "transferrin", ",", "ceruloplasmin", "and", "C0038838#ent", "<e2>", "and", "the", "functional", "activity", "of", "the", "latter", "two", "enzymes", "after", "their", "interaction", "with", "hypochlorite", "were", "studied", "."], "h": {"id": "C3536873", "name": "C3536873#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [13, 14]}}
{"token": ["In", "vitro", "of", "C1413096#ent", "<e1>", "64", "-", "0802", "on", "the", "human", "C1420131#ent", "<e2>", "hOAT1", ")", "were", "investigated", "using", "novel", "Chinese", "hamster", "ovary", "cells", "transfected", "with", "hOAT1", "."], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420131", "name": "C1420131#ent", "pos": [11, 12]}}
{"token": ["Rat", "brain", "endothelial", "cell", "gene-1", "(", "C1314754#ent", "<e1>", ")", "had", "considerable", "homology", "with", "C0079427#ent", "<e2>", "5", "(", "TUSC5", ")", "."], "h": {"id": "C1314754", "name": "C1314754#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [13, 14]}}
{"token": ["The", "most", "frequent", "indications", "for", "home", "mechanical", "ventilation", "C0012634#ent", "<e1>", "with", "restrictive", "ventilatory", "defects", "especially", "C1332928#ent", "<e2>", "neuromuscular", "disorders"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332928", "name": "C1332928#ent", "pos": [15, 16]}}
{"token": ["These", "results", "highlight", "a", "previously", "unrecognized", "link", "between", "C3539637#ent", "<e1>", ",", "mitochondria", ",", "and", "C1418401#ent", "<e2>"], "h": {"id": "C3539637", "name": "C3539637#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [14, 15]}}
{"token": ["There", "was", "no", "significant", "in", "odds", "ratios", "suggesting", "that", "the", "observed", "increase", "of", "genetic", "liability", "by", "the", "long", "C3657721#ent", "<e1>", "promoter", "allele", "not", "modified", "by", "the", "C3814032#ent", "<e2>", "polymorphism", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3814032", "name": "C3814032#ent", "pos": [26, 27]}}
{"token": ["During", "growth", "in", "the", "presence", "of", "C0077089#ent", "<e1>", ",", "extracts", "of", "yeast", "cells", "increased", "levels", "of", "C0010762#ent", "<e2>", "monooxygenase", "which", "catalyzed", "the", "oxidative", "N-dealkylation", "of", "aminoalcohols", "."], "h": {"id": "C0077089", "name": "C0077089#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [16, 17]}}
{"token": ["Resistance", "is", "high", "for", "antimalatials", "(", "C0024530#ent", "<e1>", ")", "and", "for", "Amoxycillin", ",", "C0041044#ent", "<e2>", "and", "Gentamicin", "(", "Gram-bacteria", "from", "urine", "and", "blood", ")", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041044", "name": "C0041044#ent", "pos": [13, 14]}}
{"token": ["These", "results", "were", "substantiated", "by", "the", "observations", "that", "M-3", "C0025517#ent", "<e1>", "aminopyrine", "whereas", "M-4", "C0025517#ent", "<e1>", "aminopyrine", ",", "erythromycin", "and", "C0009214#ent", "<e1>", "in", "the", "reconstituted", "system"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009214", "name": "C0009214#ent", "pos": [20, 21]}}
{"token": ["This", "report", "documents", "the", "unusual", "occurrence", "of", "rapidly", "progressive", "C0156221#ent", "<e1>", "with", "crescents", "and", "C0268749#ent", "<e2>", "a", "patient", "treated", "with", "rifampin", "."], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268749", "name": "C0268749#ent", "pos": [14, 15]}}
{"token": ["The", "data", "suggest", "that", "the", "inhibitory", "effect", "of", "C0019880#ent", "<e1>", "on", "BuChE", "activity", "is", "probably", "mediated", "by", "free", "radicals", "since", "C3714649#ent", "<e2>", "C", "administration", "such", "effect", "."], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [20, 21]}}
{"token": ["The", "present", "study", "was", "conducted", "to", "examine", "the", "relationship", "of", "plasma", "C0019880#ent", "<e1>", "to", "the", "three", "C3714649#ent", "<e2>", "and", "other", "contributing", "variables", "in", "early", "natural", "menopause"], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [16, 17]}}
{"token": ["It", "is", "concluded", "that", "C1706587#ent", "<e1>", "with", "rTNF", "induces", "a", "C0015190#ent", "<e2>", "directly", "or", "indirectly", "through", "other", "mediators", "such", "as", "IL-6", "or", "cortisol", "."], "h": {"id": "C1706587", "name": "C1706587#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015190", "name": "C0015190#ent", "pos": [10, 11]}}
{"token": ["Data", "acquisition", "carried", "out", "in", "multiple", "reaction", "monitoring", "(", "MRM", ")", "mode", ",", "by", "monitoring", "the", "transitions", "m/z", "307.3", "-", "->107.1", "for", "C0378091#ent", "<e1>", "and", "m/z", "338.4", "-", "->189.1", "for", "C0600832#ent", "<e2>", "."], "h": {"id": "C0378091", "name": "C0378091#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0600832", "name": "C0600832#ent", "pos": [30, 31]}}
{"token": ["The", "amides", "9a-d", "were", "prepared", "from", "the", "primary", "amines", "8a-d", "which", "represent", "partial", "structures", "of", "the", "H2-receptor", "antagonists", "C0378091#ent", "<e1>", ",", "cimetidine", ",", "ranitidine", ",", "and", "C0600832#ent", "<e2>", "."], "h": {"id": "C0378091", "name": "C0378091#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0600832", "name": "C0600832#ent", "pos": [26, 27]}}
{"token": ["However", ",", "no", "coding", "sequence", "mutations", "detected", "in", "C1418384#ent", "<e1>", "in", "a", "C0339573#ent", "<e2>", "patient", "from", "the", "GLC1C", "family", "."], "h": {"id": "C1418384", "name": "C1418384#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0339573", "name": "C0339573#ent", "pos": [12, 13]}}
{"token": ["C1423108#ent", "<e1>", "mRNA", "was", "expressed", "from", "8", "weeks", ",", "when", "the", "C0771711#ent", "<e2>", "was", "still", "pathologically", "normal", ",", "and", "reached", "its", "peak", "at", "12", "weeks", ",", "when", "the", "pancreatitis", "first", "appeared", "."], "h": {"id": "C1423108", "name": "C1423108#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [11, 12]}}
{"token": ["Since", "C1423108#ent", "<e1>", "is", "a", "stress", "protein", "expressed", "in", "human", "C0771711#ent", "<e2>", "during", "pancreatitis", "but", "also", "constitutively", "synthesized", "in", "the", "small", "intestine", "we", "looked", "whether", "its", "expression", "would", "be", "altered", "in", "patients", "with", "celiac", "disease"], "h": {"id": "C1423108", "name": "C1423108#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [10, 11]}}
{"token": ["More", "recent", "reports", "have", "noted", "that", "C1422070#ent", "<e1>", "comprises", "a", "significantly", "greater", "percentage", "of", "cases", "of", "C0032285#ent", "<e2>", "than", "it", "did", "in", "the", "past", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [16, 17]}}
{"token": ["The", "C0795864#ent", "<e1>", "from", "unstimulated", "C0003872#ent", "<e2>", "monocytes", "significantly", "enhanced", "neutrophil", "chemotaxis", "superoxide", "anion", "production", "."], "h": {"id": "C0795864", "name": "C0795864#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [5, 6]}}
{"token": ["Detailed", "analysis", "of", "the", "transcriptional", "activity", "various", "regions", "of", "the", "C0079429#ent", "<e1>", "showed", "that", "all", "portions", "of", "the", "MBP", "gene", "transcribed", "in", "C3539689#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539689", "name": "C3539689#ent", "pos": [22, 23]}}
{"token": ["The", "increased", "warfarin", "doses", "required", "in", "these", "two", "patients", "may", "have", "been", "caused", "by", "induction", "of", "C1176140#ent", "<e1>", "by", "nevirapine", ",", "CYP2C9", "by", "C0525005#ent", "<e2>", ",", "or", "CYP2C9", "by", "lopinavir-ritonavir", "."], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0525005", "name": "C0525005#ent", "pos": [23, 24]}}
{"token": ["E.", "coli", "O157", "isolates", "resistant", "to", "HCl", "or", "C0000975#ent", "<e1>", "were", "found", "more", "frequently", "than", "those", "resistant", "to", "other", "C3541407#ent", "<e2>"], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541407", "name": "C3541407#ent", "pos": [19, 20]}}
{"token": ["Because", "alterations", "in", "the", "bile", "ducts", "in", "C0010674#ent", "<e1>", "those", "found", "in", "C0566602#ent", "<e2>", "magnetic", "resonance", "cholangiography", "MRC", ")", "could", "be", "a", "useful", "diagnosis", "technique", ",", "especially", "because", "it", "is", "non-invasive", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [12, 13]}}
{"token": ["C1414805#ent", "<e1>", "immunopurified", "from", "culture", "cells", "tissues", "phosphorylates", "in", "vitro", "p70", "S6", "kinase", "C1705582#ent", "<e2>", ")", "alpha", "and", "p70beta", ",", "mainly", "on", "Thr412", "or", "Thr401", ",", "respectively", ",", "located", "in", "a", "Phe-Thr-Tyr", "motif", "."], "h": {"id": "C1414805", "name": "C1414805#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705582", "name": "C1705582#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "we", "present", "evidence", "indicating", "that", "p33(ING1b", ")", "affects", "the", "degree", "of", "physical", "association", "C1366837#ent", "<e1>", "PCNA", ")", "and", "C1333336#ent", "<e2>", ",", "an", "association", "that", "has", "been", "proposed", "to", "link", "DNA", "repair", "chromatin", "remodeling"], "h": {"id": "C1366837", "name": "C1366837#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333336", "name": "C1333336#ent", "pos": [20, 21]}}
{"token": ["To", "examine", "the", "inhibition", "of", "prostaglandins", "to", "the", "pressor", "activity", "C1414260#ent", "<e1>", ",", "hemodynamic", "changes", "of", "dogs", "pretreated", "with", "C0004057#ent", "<e2>", "in", "response", "to", "C1414260#ent", "<e1>", "were", "compared", "with", "those", "of", "control", "."], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "initial", "transient", "increases", "in", "either", "renal", "or", "femoral", "blood", "flow", "C1414260#ent", "<e1>", "were", "not", "affected", "by", "C0004057#ent", "<e2>", "."], "h": {"id": "C1414260", "name": "C1414260#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [19, 20]}}
{"token": ["R36a", "grown", "in", "media", "containing", "EA", "instead", "of", "CL", ",", "and", "therefore", "having", "phosphorylethanolamine", "instead", "of", "C3811118#ent", "<e1>", "in", "their", "C-polysaccharide", ",", "were", "unable", "to", "induce", "substantial", "C1418482#ent", "<e2>", "responses", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [27, 28]}}
{"token": ["Sixty-six", "Sumbanese", "Indonesians", "with", "uncomplicated", "C0024535#ent", "<e1>", "malaria", "were", "treated", "with", "C0008269#ent", "<e2>", "and", "followed", "for", "28", "days", "by", "use", "of", "1997", "World", "Health", "Organization", "criteria", "assessment", "of", "therapeutic", "efficacy", "of", "antimalarial", "drugs"], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [11, 12]}}
{"token": ["Besides", "I47A", ",", "mutation", "L76V", "at", "the", "C1440747#ent", "<e1>", "recently", "been", "proposed", "to", "cause", "C0674432#ent", "<e2>"], "h": {"id": "C1440747", "name": "C1440747#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0674432", "name": "C0674432#ent", "pos": [14, 15]}}
{"token": ["Simpson-Golabi-Behmel", "syndrome", "SGBS", ")", "is", "an", "C2936904#ent", "<e1>", "by", "pre-", "and", "postnatal", "overgrowth", "C0175695#ent", "<e2>", ")", ",", "which", "clinically", "resembles", "the", "autosomal", "Beckwith-Wiedemann", "syndrome", "BWS", ")", "."], "h": {"id": "C2936904", "name": "C2936904#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0175695", "name": "C0175695#ent", "pos": [13, 14]}}
{"token": ["We", "report", "here", "the", "x-ray", "crystal", "structure", "the", "human", "galectin-3", "C1413723#ent", "<e1>", ",", "in", "complex", "with", "lactose", "and", "C0027201#ent", "<e2>", ",", "at", "2.1-A", "resolution", "."], "h": {"id": "C1413723", "name": "C1413723#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027201", "name": "C0027201#ent", "pos": [18, 19]}}
{"token": ["The", "response", "to", "OpZ", "in", "peritoneal", "macrophages", "inhibited", "in", "a", "dose-related", "manner", "by", "both", "PGE2", "and", "C0038838#ent", "<e1>", "but", "not", "by", "indomethacin", ",", "d-penicillamine", ",", "piroxicam", "or", "C0031463#ent", "<e2>", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031463", "name": "C0031463#ent", "pos": [27, 28]}}
{"token": ["In", "addition", ",", "a", "few", "conditions", "produce", "a", "C1848862#ent", "<e1>", "often", "indistinguishable", "from", "C1321756#ent", "<e2>", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1321756", "name": "C1321756#ent", "pos": [13, 14]}}
{"token": ["Aryl", "hydrocarbon", "receptor", "cytochrome", "P4501A1", "CYP1A1", ")", "and", "C3539597#ent", "<e1>", "(", "CYP1B1", ")", "have", "been", "shown", "to", "metabolically", "activate", "C0085169#ent", "<e2>", "."], "h": {"id": "C3539597", "name": "C3539597#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085169", "name": "C0085169#ent", "pos": [19, 20]}}
{"token": ["Male", "mice", "lacking", "both", "the", "C1332738#ent", "<e1>", "and", "Ink4d", "genes", "which", "encode", "two", "inhibitors", "of", "C0080054#ent", "<e2>", "Cdks", ")", ",", "are", "infertile", ",", "whereas", "female", "fecundity", "is", "unaffected", "."], "h": {"id": "C1332738", "name": "C1332738#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [15, 16]}}
{"token": ["The", "clinical", ",", "echocardiographic", ",", "and", "catheterization", "findings", "in", "a", "patient", "with", "C0012628#ent", "<e1>", "aneurysm", "of", "the", "membranous", "interventricular", "septum", "and", "C1843003#ent", "<e2>", "presented", "."], "h": {"id": "C0012628", "name": "C0012628#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1843003", "name": "C1843003#ent", "pos": [21, 22]}}
{"token": ["The", "pharmacodynamic", "profile", "C1955822#ent", "<e1>", "has", "been", "assessed", "and", "compared", "with", "widely", "used", "C0003211#ent", "<e2>", "in", "different", "animal", "models"], "h": {"id": "C1955822", "name": "C1955822#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [13, 14]}}
{"token": ["Radiation", "hybrid", "analysis", "mapped", "the", "C1415198#ent", "<e1>", "human", "chromosome", "13", "very", "near", "the", "C1415197#ent", "<e2>", "a", "member", "of", "the", "glypican", "family", "strong", "similarity", "to", "GPC3", "."], "h": {"id": "C1415198", "name": "C1415198#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415197", "name": "C1415197#ent", "pos": [13, 14]}}
{"token": ["Eicosanoids", "are", "synthesized", "by", "C1426677#ent", "<e1>", "through", "the", "action", "of", "cyclooxygenase", "and", "C0023835#ent", "<e2>", "enzymes", "and", "serve", "to", "modulate", "the", "proinflammatory", "function", "this", "cell", "as", "part", "of", "the", "lungs", "'", "host", "defense", "mechanism"], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023835", "name": "C0023835#ent", "pos": [12, 13]}}
{"token": ["Bone", "section", "histology", "C3887650#ent", "<e1>", "and", "osteitis", "fibrosa", "and", "the", "C0020502#ent", "<e2>", "at", "this", "stage", "was", "considered", "to", "be", "secondary", "to", "C3887650#ent", "<e1>", "with", "postgastrectomy", "steatorrhoea", "."], "h": {"id": "C0020502", "name": "C0020502#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3887650", "name": "C3887650#ent", "pos": [3, 4]}}
{"token": ["Addition", "of", "geranylgeranyl", "pyrophosphate", "the", "reaction", "mixture", "inhibited", "incorporation", "of", "radioactivity", "into", "ralA", "and", "C0767970#ent", "<e1>", "but", "not", "cH-ras", "suggesting", "that", "both", "ralA", "and", "C0812283#ent", "<e2>", "geranylgeranylated", "."], "h": {"id": "C0767970", "name": "C0767970#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812283", "name": "C0812283#ent", "pos": [24, 25]}}
{"token": ["The", "Na+-dependent", "component", "can", "be", "inhibited", "by", "C2347318#ent", "<e1>", "and", "L-phenylalanine", "but", "can", "not", "interact", "either", "with", "C0815040#ent", "<e2>", "with", "alpha-(methylamino)isobutyrate", "(", "MeAIB", ")", "."], "h": {"id": "C2347318", "name": "C2347318#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "dADA3", "plays", "a", "role", "in", "C1540026#ent", "<e1>", "complexes", "which", "acetylate", "H3", "and", "C1415443#ent", "<e2>", "at", "specific", "residues", "."], "h": {"id": "C1540026", "name": "C1540026#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415443", "name": "C1415443#ent", "pos": [15, 16]}}
{"token": ["Homologous", "binding", "experiments", "using", "a", "carp", "liver", "microsomal", "fraction", "revealed", "a", "single", "receptor", "population", "with", "C1705240#ent", "<e1>", "=", "0.77", "nM", "and", "Bmax", "=", "241", "fmol/mg", "C0001214#ent", "<e2>"], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001214", "name": "C0001214#ent", "pos": [25, 26]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "whether", "C0061323#ent", "<e1>", ",", "an", "oral", "C0038766#ent", "<e2>", "prevents", "the", "onset", "of", "diabetes", "in", "diabetic", "prone", "BB", "rats", "."], "h": {"id": "C0061323", "name": "C0061323#ent", "pos": [9, 10]}, "relation": "has_structural_class", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [14, 15]}}
{"token": ["Of", "the", "twenty-two", "patients", "studied", "with", "C0023348#ent", "<e1>", "thirteen", "had", "clinical", "evidence", "C0022408#ent", "<e2>", "nine", "of", "these", "patients", "had", "raised", "PBL", "transformation", "and", "LAI", "reactivity", "to", "the", "testis", "extracts", "."], "h": {"id": "C0023348", "name": "C0023348#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022408", "name": "C0022408#ent", "pos": [12, 13]}}
{"token": ["Multiple", "sequence", "alignment", "15", "different", "C0769218#ent", "<e1>", "greatest", "homology", "with", "C0038601#ent", "<e2>", "from", "gram-positive", "bacteria", "than", "archaeal", "or", "eukaryal", "serine", "proteases", "."], "h": {"id": "C0769218", "name": "C0769218#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038601", "name": "C0038601#ent", "pos": [10, 11]}}
{"token": ["These", "findings", "indicate", "that", "the", "selection", "of", "the", "scissile", "bond", "by", "the", "extended", "substrate-binding", "site", "of", "human", "C1413516#ent", "<e1>", "more", "restricted", "than", "that", "in", "other", "C0055673#ent", "<e2>", "."], "h": {"id": "C1413516", "name": "C1413516#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [25, 26]}}
{"token": ["Acute", "sinusitis", "adults", "is", "manifested", "by", "fever", ",", "facial", "pain", "C1260880#ent", "<e1>", "but", "children", "--", "who", "rarely", "have", "headache", "or", "C0234233#ent", "<e2>", "have", "persistent", "cough", "in", "addition", "to", "fever", "and", "C1260880#ent", "<e1>"], "h": {"id": "C0234233", "name": "C0234233#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [10, 11]}}
{"token": ["No", "effects", "CD4", ",", "CD8a", ",", "C1413204#ent", "<e1>", "and", "MPO", "expression", "were", "noticed", "in", "C1704467#ent", "<e2>", "pretreated", "livers", ",", "whereas", "Igbeta", "was", "slightly", "enhanced", "compared", "to", "controls", "."], "h": {"id": "C1413204", "name": "C1413204#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [14, 15]}}
{"token": ["The", "C1419818#ent", "<e1>", "spectrum", "of", "a", "commercial", "primer", "containing", "C0171284#ent", "<e2>", "exhibits", "a", "similar", "spectral", "pattern"], "h": {"id": "C1419818", "name": "C1419818#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0171284", "name": "C0171284#ent", "pos": [9, 10]}}
{"token": ["C0014158#ent", "<e1>", "digestion", "of", "C1420836#ent", "<e2>", "that", "C1420836#ent", "<e2>", "a", "small", "number", "of", "asparagine-linked", "oligosaccharide", "chains", "and", "that", "the", "epitope", "that", "is", "recognized", "by", "18A10", "monoclonal", "antibody", "not", "on", "the", "asparagine-linked", "oligosaccharide", "portion", "."], "h": {"id": "C0014158", "name": "C0014158#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420836", "name": "C1420836#ent", "pos": [4, 5]}}
{"token": ["We", "describe", "a", "rare", "case", "of", "C3280574#ent", "<e1>", "a", "young", "woman", "with", "C0013404#ent", "<e2>", "and", "progressive", "hypoxaemia", "due", "to", "the", "alveolar", "deposition", "insoluble", ",", "surfactant-like", "material", "."], "h": {"id": "C3280574", "name": "C3280574#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [12, 13]}}
{"token": ["However", ",", "C3540564#ent", "<e1>", "and", "C2827383#ent", "<e2>", "regulated", "by", "distinct", "mechanisms", ",", "and", "C2827383#ent", "<e2>", "but", "not", "C3540564#ent", "<e1>", ",", "is", "the", "physiological", "S6", "kinase", "in", "vivo", "other", "cell", "types"], "h": {"id": "C3540564", "name": "C3540564#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [5, 6]}}
{"token": ["We", "further", "show", "that", "TGFbeta", "activates", "the", "C0380051#ent", "<e1>", "JNK", ")", "pathway", "in", "myoblastic", "cells", "C1419227#ent", "<e2>", "and", "Cdc42Hs", "GTPases", "."], "h": {"id": "C0380051", "name": "C0380051#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419227", "name": "C1419227#ent", "pos": [15, 16]}}
{"token": ["Of", "the", "67", "%", "having", "some", "C0031315#ent", "<e1>", "the", "latest", "interview", "50", "%", "reported", "that", "C0238637#ent", "<e2>", "were", "decreasing", "."], "h": {"id": "C0031315", "name": "C0031315#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0238637", "name": "C0238637#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "induction", "of", "differentiation", "(", "hemoglobin", "synthesis", "in", "Friend", "erythroleukemic", "cells", "C0012403#ent", "<e1>", "a", "decrease", "in", "the", "contents", "of", "C1333908#ent", "<e2>", "and", "-2", "."], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333908", "name": "C1333908#ent", "pos": [20, 21]}}
{"token": ["More", "recently", ",", "the", "device-based", "therapy", "of", "deep", "brain", "stimulation", "DBS", ")", "has", "emerged", "as", "the", "preferred", "surgical", "treatment", "C0393593#ent", "<e1>", "and", "other", "C0026650#ent", "<e2>", "most", "patients", "who", "require", "operative", "intervention"], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [23, 24]}}
{"token": ["The", "aim", "of", "this", "case", "report", "to", "call", "attention", "to", "C0054318#ent", "<e1>", "SCAD", ")", "deficiency", "as", "a", "possible", "contributory", "factor", "to", "C0020615#ent", "<e2>", "in", "childhood", "."], "h": {"id": "C0054318", "name": "C0054318#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [21, 22]}}
{"token": ["Like", "mammalian", "APAF-1", ",", "HAC-1", "can", "activate", "C0534519#ent", "<e1>", "in", "a", "C0101555#ent", "<e2>", "manner", "in", "vitro"], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [11, 12]}}
{"token": ["The", "C0030828#ent", "<e1>", "Eschericha", "coli", "8743", "is", "a", "reversible", "C0014442#ent", "<e2>", "."], "h": {"id": "C0030828", "name": "C0030828#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["Pirprofen", "and", "C0031982#ent", "<e1>", "seem", "to", "have", "an", "equivalent", "analgesic", "effect", "pirprofen", "(", "C0140193#ent", "<e2>", ")", "seems", "to", "act", "a", "little", "faster", "and", "to", "be", "better", "tolerated", "than", "C0031982#ent", "<e1>", "."], "h": {"id": "C0031982", "name": "C0031982#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0140193", "name": "C0140193#ent", "pos": [13, 14]}}
{"token": ["C1417830#ent", "<e1>", "activated", "IKKalpha", "and", "C3272750#ent", "<e2>", "in", "the", "presence", "of", "TAB1", "."], "h": {"id": "C1417830", "name": "C1417830#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272750", "name": "C3272750#ent", "pos": [5, 6]}}
{"token": ["C0042769#ent", "<e1>", "the", "gastrointestinal", "tract", "leading", "to", "C0152517#ent", "<e2>", ",", "are", "a", "common", "problem", "in", "both", "developed", "and", "developing", "countries"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0152517", "name": "C0152517#ent", "pos": [7, 8]}}
{"token": ["However", ",", "additional", "prevention", "of", "C0042769#ent", "<e1>", "especially", "NLV", ",", "might", "significantly", "decrease", "the", "number", "of", "C0152517#ent", "<e2>", "cases", "in", "the", "community", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0152517", "name": "C0152517#ent", "pos": [16, 17]}}
{"token": ["Polymorphic", "sites", "the", "three", "C0796517#ent", "<e1>", "genes", "have", "been", "identified", "both", "in", "the", "C1412821#ent", "<e2>", "well", "as", "in", "introns", "and", "the", "regulatory", "5'", "region"], "h": {"id": "C0796517", "name": "C0796517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [13, 14]}}
{"token": ["The", "enzyme", "inhibition", "by", "MMA", "may", "lead", "to", "various", "C0025517#ent", "<e1>", "well", "as", "inhibition", "of", "C1563761#ent", "<e2>", "vitamin", "B-12-deficient", "mammals", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1563761", "name": "C1563761#ent", "pos": [15, 16]}}
{"token": ["Also", ",", "the", "C0003308#ent", "<e1>", "SF", "86", "-", "327", "and", "C0068367#ent", "<e2>", "against", "18", "dimorphic", "pathogens", "were", "assayed", "in", "vitro", "broth", "dilution"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0068367", "name": "C0068367#ent", "pos": [10, 11]}}
{"token": ["C0919432#ent", "<e1>", "siRNA", "inhibits", "beta-TrCP-Cdc25A", "interaction", "and", "C1739021#ent", "<e2>", "degradation", "in", "response", "to", "TGF-beta", "."], "h": {"id": "C0919432", "name": "C0919432#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1739021", "name": "C1739021#ent", "pos": [7, 8]}}
{"token": ["Recent", "molecular", "cloning", "revealed", "the", "existence", "of", "a", "LOX", "family", "of", "LOX", "and", "four", "C3272401#ent", "<e1>", "LOXLs", ";", "LOXL", ",", "C1416899#ent", "<e2>", ",", "LOXL3", ",", "and", "LOXL4", ")", "."], "h": {"id": "C3272401", "name": "C3272401#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416899", "name": "C1416899#ent", "pos": [20, 21]}}
{"token": ["Tonsil", "B-cells", "to", "phorbol", "ester", "C0078956#ent", "<e1>", ")", "by", "an", "increased", "beta", "2", "m", "production", "rate", ",", "which", "was", "further", "enhanced", "by", "the", "combined", "stimuli", "of", "C0078956#ent", "<e1>", "plus", "the", "C0022022#ent", "<e1>", "A23187", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [30, 31]}}
{"token": ["Dexamethasone", "treatment", "of", "the", "Jurkat", "T77", "cell", "clone", "inhibited", "the", "enhancing", "effect", "of", "12-O-tetradecanoylporbol-13-acetate", "(", "C0078956#ent", "<e1>", ")", "and", "the", "C0022022#ent", "<e2>", "A23187", "on", "the", "interleukin", "2", "IL2", ")", "mRNA", "levels", "and", "gene", "transcription", "intact", "nuclei", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [20, 21]}}
{"token": ["It", "stimulates", "thyroid", "functions", "specific", "membrane", "TSH", "receptor", "(", "C1336679#ent", "<e1>", ")", "that", "belongs", "to", "the", "superfamily", "of", "G", "protein-coupled", "receptors", "C3812695#ent", "<e2>", ")", "."], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3812695", "name": "C3812695#ent", "pos": [21, 22]}}
{"token": ["C1421356#ent", "<e1>", "-", "1", ",", "a", "mammalian", "homologue", "of", "C0949990#ent", "<e2>", ",", "is", "a", "presynaptic", "phorbol", "ester", "receptor", "enhances", "neurotransmitter", "release", "."], "h": {"id": "C1421356", "name": "C1421356#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0949990", "name": "C0949990#ent", "pos": [9, 10]}}
{"token": ["Our", "data", "showed", "that", "a", "severe", "sensorimotor", "axonal", "neuropathy", "in", "C0085179#ent", "<e1>", "suggestive", "of", "C0032541#ent", "<e2>"], "h": {"id": "C0085179", "name": "C0085179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032541", "name": "C0032541#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "whether", "ZPP", "is", "influenced", "by", "increased", "iron", "levels", "hereditary", "hemochromatosis", "C1418983#ent", "<e1>", ")", "and", "is", "useful", "in", "the", "clarification", "of", "C3854388#ent", "<e2>", "."], "h": {"id": "C1418983", "name": "C1418983#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3854388", "name": "C3854388#ent", "pos": [28, 29]}}
{"token": ["MCPG", "(", "500", "microM", ")", "had", "no", "significant", "effect", "on", "the", "C0007681#ent", "<e1>", "potency", "of", "C1425179#ent", "<e2>", "."], "h": {"id": "C0007681", "name": "C0007681#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1425179", "name": "C1425179#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "effectiveness", "and", "safety", "of", "the", "combination", "of", "artesunate", ",", "C0038679#ent", "<e1>", "+", "pyrimethamine", "and", "primaquine", "in", "the", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0038679", "name": "C0038679#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [21, 22]}}
{"token": ["The", "validity", "of", "C1366509#ent", "<e1>", "as", "an", "effective", "antiinflammatory", "and", "C0728960#ent", "<e2>", "particularly", "in", "the", "relief", "of", "arthritic", "symptoms", "has", "been", "investigated", "in", "numerous", "animal", ",", "clinical", "and", "in", "vitro", "studies", "."], "h": {"id": "C1366509", "name": "C1366509#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [10, 11]}}
{"token": ["C0039286#ent", "<e1>", "increased", "cerebral", "cortical", "C1420173#ent", "<e2>", "and", "4", "mRNA", "levels", ",", "but", "did", "not", "affect", "Glut1", ",", "IGF1", ",", "or", "IGF1", "receptor", "expression", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420173", "name": "C1420173#ent", "pos": [5, 6]}}
{"token": ["The", "mathematical", "functions", "closely", "mimic", "the", "Ca2", "+", "dependence", "of", "C0001492#ent", "<e1>", "AC", ")", "and", "C0671566#ent", "<e2>", "GC", ")", "activities", "as", "documented", "in", "P.", "tetraurelia", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0671566", "name": "C0671566#ent", "pos": [15, 16]}}
{"token": ["The", "difference", "in", "the", "amount", "of", "proviral", "DNA", "detected", "after", "infection", "of", "fresh", "thymocytes", "with", "C1538067#ent", "<e1>", "-", "3", "or", "JR-CSF", "correlated", "with", "the", "levels", "of", "C1332823#ent", "<e2>", "and", "CCR5", "surface", "expression", "."], "h": {"id": "C1538067", "name": "C1538067#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [26, 27]}}
{"token": ["Various", "clinical", "conditions", "like", "trauma", ",", "infection", "(", "tuberculous", ",", "C0003869#ent", "<e1>", ",", "etc", ")", ",", "malignancy", ",", "rheumatological", "diseases", "neurological", "disorders", "C1456654#ent", "<e2>", "back", "pain", "and", "also", "some", "systemic", "illnesses", "the", "same", "."], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1456654", "name": "C1456654#ent", "pos": [22, 23]}}
{"token": ["Neither", "C1420087#ent", "<e1>", "nor", "ILBP", "levels", "differed", "significantly", "between", "C0947622#ent", "<e2>", "carriers", "and", "controls", "."], "h": {"id": "C1420087", "name": "C1420087#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [9, 10]}}
{"token": ["Our", "data", "demonstrate", "that", "RNAPII", "CTD", "is", "dephosphorylated", "by", "C1418858#ent", "<e1>", "in", "vitro", "by", "PPP-type", "phosphatase", ",", "distinct", "from", "C1413790#ent", "<e2>", ",", "in", "vivo"], "h": {"id": "C1418858", "name": "C1418858#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413790", "name": "C1413790#ent", "pos": [19, 20]}}
{"token": ["An", "estimated", "16", "million", "people", "in", "the", "US", "are", "currently", "diagnosed", "with", "C0024117#ent", "<e1>", ",", "the", "majority", "having", "C0008677#ent", "<e2>"], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [18, 19]}}
{"token": ["Chronic", "obstructive", "pulmonary", "disease", "C0024117#ent", "<e1>", ")", "is", "characterized", "mainly", "by", "airway", "obstruction", "to", "C0008677#ent", "<e2>", "emphysema", "."], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "intracellular", "H2O2", "level", "was", "decreased", "by", "EGCG", "treatment", ",", "suggesting", "that", "the", "C3543842#ent", "<e1>", "maintenance", "of", "intracellular", "H2O2", "may", "be", "required", "for", "cell", "adhesion", "C0009325#ent", "<e2>", "."], "h": {"id": "C3543842", "name": "C3543842#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [26, 27]}}
{"token": ["We", "generated", "zebra", "C3274826#ent", "<e1>", "embryos", "that", "lack", "the", "miRNA-processing", "enzyme", "C1333218#ent", "<e2>", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333218", "name": "C1333218#ent", "pos": [11, 12]}}
{"token": ["Recombinant", "C1335199#ent", "<e1>", "inhibited", "the", "GTPase", "activity", "several", "C0086376#ent", "<e2>", "and", "also", "inhibited", "Gs-mediated", "adenylyl", "cyclase", "."], "h": {"id": "C1335199", "name": "C1335199#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["C0036416#ent", "<e1>", "and", "severe", "retinopathy", "require", "systemic", "immunosuppression", "episcleritis", ",", "C0701807#ent", "<e2>", "dry", "eyes", "usually", "be", "managed", "with", "local", "eye", "drops"], "h": {"id": "C0036416", "name": "C0036416#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0701807", "name": "C0701807#ent", "pos": [10, 11]}}
{"token": ["Azathioprine", "was", "beneficial", "for", "C0036416#ent", "<e1>", "but", "was", "less", "effective", "for", "C0701807#ent", "<e2>", "especially", "in", "Crohn's", "disease", "thus", "necessitating", "the", "use", "of", "another", "cytotoxic", "agent"], "h": {"id": "C0036416", "name": "C0036416#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0701807", "name": "C0701807#ent", "pos": [11, 12]}}
{"token": ["We", "found", "that", "C1420423#ent", "<e1>", "induced", "expression", "of", "iNOS", "and", "C1705323#ent", "<e2>", "in", "RPE", "cells", "the", "mRNA", "and", "protein", "levels", "a", "time-and", "dose-dependent", "manner", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [10, 11]}}
{"token": ["In", "this", "brief", "review", "we", "discuss", "how", "the", "known", "and", "potential", "insulin", "sensitizers", "metformin", ",", "C0003620#ent", "<e1>", "thiazolidinediones", ",", "and", "the", "new", "class", "of", "centrally", "acting", "C0003364#ent", "<e2>", "I1-receptor", "agonists", ",", "may", "work", "."], "h": {"id": "C0003620", "name": "C0003620#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [26, 27]}}
{"token": ["Cytohesin-1", "and", "ARNO", "are", "C0120465#ent", "<e1>", "GEFs", ")", "for", "ADP-ribosylation", "factor", "C1705280#ent", "<e2>", ")", "."], "h": {"id": "C0120465", "name": "C0120465#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [11, 12]}}
{"token": ["BIG2", "is", "a", "guanine", "nucleotide", "exchange", "factor", "C0120465#ent", "<e1>", ")", "for", "the", "ADP-ribosylation", "factor", "C1705280#ent", "<e2>", ")", "family", "of", "small", "GTPases", ",", "which", "regulate", "membrane", "association", "COPI", "and", "adaptor", "protein", "coat", "protein", "complexes"], "h": {"id": "C0120465", "name": "C0120465#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [14, 15]}}
{"token": ["The", "Sec7", "domain", "is", "approximately", "200", "amino", "acids", "size", "and", "stimulates", "C0120465#ent", "<e1>", "members", "of", "the", "C1705280#ent", "<e2>", "class", "of", "small", "GTPases"], "h": {"id": "C0120465", "name": "C0120465#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [16, 17]}}
{"token": ["The", "existence", "of", "the", "C1823521#ent", "<e1>", "PBR", ")", "in", "C1412137#ent", "<e2>", "been", "demonstrated", "in", "this", "laboratory", "."], "h": {"id": "C1823521", "name": "C1823521#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [9, 10]}}
{"token": ["No", "cross-reactions", "were", "noted", "between", "C0037231#ent", "<e1>", "soluble", "SCM", "and", "C0162745#ent", "<e2>", "soluble", "GBM", "."], "h": {"id": "C0037231", "name": "C0037231#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [10, 11]}}
{"token": ["Hereditary", "monogenic", "kidney", "stone", "diseases", "are", "rare", "C0012634#ent", "<e1>", ",", "since", "they", "account", "for", "nearly", "2", "%", "of", "C0022650#ent", "<e2>", "cases", "in", "adults", "and", "10", "%", "in", "children", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "indicate", "that", "a", "rational", "choice", "of", "cytokines", "can", "be", "made", "given", "the", "known", "sensitivity", "of", "tumor", "cells", "C1418887#ent", "<e1>", ",", "FasL", ",", "and", "tumor", "necrosis", "factor-related", "apoptosis-inducing", "ligand", "the", "C1425775#ent", "<e2>", "ligand", "status", "of", "tumor", "metastases"], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1425775", "name": "C1425775#ent", "pos": [31, 32]}}
{"token": ["These", "studies", "with", "inbred", "mice", "defined", "previously", "unrecognized", "C1417679#ent", "<e1>", "that", "control", "the", "length", "of", "C0074204#ent", "<e2>", "and", "CJD", "incubation", "periods", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0074204", "name": "C0074204#ent", "pos": [15, 16]}}
{"token": ["The", "activation", "of", "cyclophosphamide", "yields", "a", "cytotoxic", "metabolite", "C0010583#ent", "<e1>", "which", "is", "highly", "reactive", "and", "detoxified", "through", "C1260386#ent", "<e2>", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [17, 18]}}
{"token": ["We", "introduce", "a", "new", "algorithm", "that", "quantifies", "C4049859#ent", "<e1>", "organization", "by", "the", "mean-squared", "error", "(", "C3537320#ent", "<e2>", ")", "in", "the", "linear", "prediction", "two", "cardiac", "electrograms"], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537320", "name": "C3537320#ent", "pos": [15, 16]}}
{"token": ["C3539185#ent", "<e1>", "are", "frequently", "necessary", "to", "C0035435#ent", "<e2>", "flares", "and", "for", "prevention", "of", "serious", "organ", "manifestations", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [6, 7]}}
{"token": ["Both", "C1335285#ent", "<e1>", "and", "mammalian", "C0299081#ent", "<e2>", "type", "I", "integral", "membrane", "proteins", "contain", "a", "58-residue", "cytosolic", "C-terminal", "tail", "that", "is", "highly", "conserved", "between", "duck", "and", "rat", "."], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0299081", "name": "C0299081#ent", "pos": [5, 6]}}
{"token": ["To", "investigate", "the", "effect", "of", "horizontal", "platform", "supported", "(", "C0242994#ent", "<e1>", ")", "prosthesis", "on", "cementless", "total", "hip", "replacement", "surgical", "treatment", "C0003864#ent", "<e2>", "in", "a", "long-term", "follow-up", "study", "."], "h": {"id": "C0242994", "name": "C0242994#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [20, 21]}}
{"token": ["These", "symbionts", "are", "thought", "to", "provide", "C3541394#ent", "<e1>", ",", "e.g.", ",", "cellulase", "and", "C0085544#ent", "<e2>", ",", "which", "assist", "the", "host", "in", "utilizing", "wood", "as", "a", "primary", "food", "source", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085544", "name": "C0085544#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "C1424250#ent", "<e1>", "stimulates", "the", "NF-kappaB", "transcription", "factor", "pathway", "activating", "latent", "DNA-binding", "activity", "C2986464#ent", "<e2>", "a", "phorbol", "ester-sensitive", "(", "PKC-dependent", ")", "mechanism", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [15, 16]}}
{"token": ["The", "deduced", "protein", "sequences", "7", "cDNAs", "encoding", "putative", "alpha-amylase", ",", "cysteine", "proteinase", "C0041236#ent", "<e1>", ",", "chymotrypsin", ",", "cellulase", ",", "C0032491#ent", "<e2>", "and", "xylanase", "display", "all", "the", "structural", "features", "characterize", "these", "enzymes", "in", "other", "eukaryotic", "organisms"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0032491", "name": "C0032491#ent", "pos": [19, 20]}}
{"token": ["At", "present", ",", "more", "than", "ten", "C1334284#ent", "<e1>", "been", "identified", "as", "causing", "human", "C0019247#ent", "<e2>"], "h": {"id": "C1334284", "name": "C1334284#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "the", "LDL", "receptor", "LDLR", ")", "cause", "C0020445#ent", "<e1>", "FH", ")", "in", "an", "C2936739#ent", "<e2>", "."], "h": {"id": "C0020445", "name": "C0020445#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [14, 15]}}
{"token": ["Renal", "pathology", "findings", "included", "C0744422#ent", "<e1>", "class", "IVb", ")", "and", "lupus", "vasculopathy", "LV", ")", "with", "C0020951#ent", "<e2>", "deposition", "within", "glomerular", "capillaries", "the", "preglomerular", "arteriolar", "lumen", "."], "h": {"id": "C0744422", "name": "C0744422#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [15, 16]}}
{"token": ["Concurrently", ",", "the", "glucose-6-phosphate", "dehydrogenase", "G-6-PDH", ";", "C0017757#ent", "<e1>", "activity", "in", "hyperhydric", "leaves", "was", "increased", "but", "C0017713#ent", "<e2>", "(", "GK", ";", "EC", "2.7.1.2", ")", "activity", "was", "unchanged", "."], "h": {"id": "C0017757", "name": "C0017757#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017713", "name": "C0017713#ent", "pos": [16, 17]}}
{"token": ["Strains", "S12", ",", "S20", ",", "and", "C1419723#ent", "<e1>", "contained", "the", "nitrogen", "fixation", "gene", "C4284736#ent", "<e2>", ",", "but", "only", "S12", "was", "able", "to", "reduce", "acetylene", "in", "pure", "culture"], "h": {"id": "C1419723", "name": "C1419723#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4284736", "name": "C4284736#ent", "pos": [13, 14]}}
{"token": ["In", "rat", "pancreatic", "islets", "2-bromopalmitate", ",", "cerulenin", ",", "and", "polyunsaturated", "fatty", "acids", "all", "of", "which", "suppress", "C0639839#ent", "<e1>", ",", "blocked", "the", "distal", "inhibitory", "effects", "of", "C3887648#ent", "<e2>", "in", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0639839", "name": "C0639839#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [25, 26]}}
{"token": ["C0078083#ent", "<e1>", "was", "microinjected", "into", "the", "anterior", "hypothalamus", "1", "before", "the", "microinjection", "of", "C1706109#ent", "<e2>", "while", "d(CH2)5Tyr(Me)AVP", "and", "C1706109#ent", "<e2>", "were", "prepared", "together", "and", "delivered", "as", "a", "single", "microinjection", "."], "h": {"id": "C0078083", "name": "C0078083#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706109", "name": "C1706109#ent", "pos": [13, 14]}}
{"token": ["Accordingly", ",", "cinnamic", "acid", "C0048207#ent", "<e1>", "but", "not", "phenylalanine", "can", "inhibit", "the", "initial", "appearance", "of", "C1428072#ent", "<e2>", "activity", "."], "h": {"id": "C0048207", "name": "C0048207#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1428072", "name": "C1428072#ent", "pos": [15, 16]}}
{"token": ["However", ",", "activation", "of", "caspase-9", "and", "cleavage", "of", "C1567710#ent", "<e1>", "caused", "by", "1403P-3", "were", "not", "inhibited", "by", "C0911901#ent", "<e2>", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0911901", "name": "C0911901#ent", "pos": [17, 18]}}
{"token": ["Keratoconjunctivitis", "sicca", "C1855648#ent", "<e1>", ")", ",", "characterised", "by", "aqueous", "C0162429#ent", "<e2>", "is", "the", "most", "common", "ocular", "complication", "adult", "rheumatoid", "arthritis", "RA", ")", "."], "h": {"id": "C1855648", "name": "C1855648#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [9, 10]}}
{"token": ["HS", "produced", "a", "rapid", "and", "transient", "activation", "of", "ERK1/2", "and", "C1705632#ent", "<e1>", "and", "also", "increased", "C0287531#ent", "<e2>", "MKP-1", ")", "protein", "and", "mRNA", "levels", "."], "h": {"id": "C1705632", "name": "C1705632#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0287531", "name": "C0287531#ent", "pos": [15, 16]}}
{"token": ["To", "review", "and", "analyse", "the", "evidence", "for", "the", "cholesterol-lowering", "effect", "C1142985#ent", "<e1>", "in", "adult", "patients", "with", "C0020443#ent", "<e2>", "who", "are", "not", "at", "low-density", "lipoprotein", "cholesterol", "LDL-C", ")", "goal", "on", "statin", "monotherapy", "."], "h": {"id": "C1142985", "name": "C1142985#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [16, 17]}}
{"token": ["These", "results", "indicate", "that", "C0039663#ent", "<e1>", "decreases", "host", "resistance", "to", "herpes", "simplex", "virus", "type", "2", "C0404521#ent", "<e2>", "the", "guinea", "pig", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0404521", "name": "C0404521#ent", "pos": [15, 16]}}
{"token": ["Complicating", "the", "issue", "is", "that", "AIR", "can", "be", "a", "secondary", "complication", "other", "conditions", "such", "as", "C0220701#ent", "<e1>", "ocular", "trauma", "birdshot", "retinopathy", ",", "C0730298#ent", "<e2>", "AZOOR", ")", ",", "or", "multiple", "evanescent", "white", "dot", "syndrome", "MEWDS", ")", "."], "h": {"id": "C0220701", "name": "C0220701#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0730298", "name": "C0730298#ent", "pos": [22, 23]}}
{"token": ["S1P", "treatment", "transiently", "activated", "Erk-1/-2", "in", "a", "dose-dependent", "manner", ",", "and", "its", "activation", "was", "blocked", "by", "C0043167#ent", "<e1>", "expression", "of", "RasN17", ",", "or", "inhibition", "of", "C1425569#ent", "<e2>", "or", "MEK-1/-2", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1425569", "name": "C1425569#ent", "pos": [25, 26]}}
{"token": ["We", "found", "that", "C0010531#ent", "<e1>", "PKA", ")", ",", "but", "not", "a", "variety", "of", "other", "C0072402#ent", "<e2>", "can", "specifically", "phosphorylate", "LPL", "and", "LPL-derived", "peptides", "on", "Ser(5", ")", "in", "vitro"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [14, 15]}}
{"token": ["Type", "1", "17", "C3489584#ent", "<e1>", "is", "a", "protein", "of", "327", "C3539946#ent", "<e2>", "the", "formation", "of", "17", "beta-estradiol", "from", "estrone", "."], "h": {"id": "C3489584", "name": "C3489584#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [10, 11]}}
{"token": ["In", "cystic", "fibrosis", "transmembrane", "conductance", "regulator", "C1413365#ent", "<e1>", ")", "knockout", "mice", "the", "duodenal", "Isc", "response", "to", "C0249083#ent", "<e2>", "was", "markedly", "reduced", ",", "but", "not", "eliminated", ",", "despite", "having", "a", "similar", "density", "of", "functional", "receptors"], "h": {"id": "C1413365", "name": "C1413365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0249083", "name": "C0249083#ent", "pos": [16, 17]}}
{"token": ["All", "members", "of", "the", "Artiodactyla", "(", "family", "Bovidae", "examined", "exhibited", "a", "large", "C1305923#ent", "<e1>", "comparable", "to", "that", "of", "the", "beta", "subunit", "human", "C1704665#ent", "<e2>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [22, 23]}}
{"token": ["The", "child", "with", "undiagnosed", "C0013264#ent", "<e1>", "had", "no", "symptoms", "of", "C0013264#ent", "<e1>", "and", "had", "received", "halothane", "twice", "before", ",", "without", "C0012792#ent", "<e1>", ",", "with", "no", "apparent", "difficulty", "."], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012792", "name": "C0012792#ent", "pos": [20, 21]}}
{"token": ["A", "straightforward", "relationship", "is", "demonstrated", "between", "C0042402#ent", "<e1>", "properties", "and", "plasma", "levels", "either", "C0144415#ent", "<e2>", "or", "diltiazem", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0144415", "name": "C0144415#ent", "pos": [13, 14]}}
{"token": ["C1705592#ent", "<e1>", "was", "significantly", "elevated", "in", "both", "C0026769#ent", "<e2>", "C-multiple", "sclerosis", "patients", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [7, 8]}}
{"token": ["IL-17", ",", "C1705592#ent", "<e1>", "and", "IL-5", "were", "significantly", "higher", "in", "C0026769#ent", "<e2>", "patients", "than", "in", "C-multiple", "sclerosis", "patients", "."], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [10, 11]}}
{"token": ["Before", "therapy", ",", "the", "%", "C0022104#ent", "<e1>", "was", "slightly", "greater", "in", "patients", "with", "C1623038#ent", "<e2>", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "mast", "C1537486#ent", "<e1>", "pivotal", "for", "activating", "a", "cardiac", "renin-angiotensin", "system", "to", "excessive", "C3887648#ent", "<e2>", "release", "in", "ischemia/reperfusion", "."], "h": {"id": "C1537486", "name": "C1537486#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [14, 15]}}
{"token": ["The", "C0003299#ent", "<e1>", "diazepam", ",", "clonazepam", ",", "phenobarbital", ",", "valproate", ",", "and", "C0041038#ent", "<e2>", "protect", "against", "pilocarpine-induced", "convulsions", ",", "while", "diphenylhydantoin", "and", "carbamazepine", "are", "ineffective", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0041038", "name": "C0041038#ent", "pos": [12, 13]}}
{"token": ["Like", "Pax6", ",", "C1425962#ent", "<e1>", "activates", "jellyfish", "crystallin", "and", "Drosophila", "rhodopsin", "C0812235#ent", "<e2>", "promoters", "and", "induces", "small", "ectopic", "eyes", "in", "Drosophila", "."], "h": {"id": "C1425962", "name": "C1425962#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812235", "name": "C0812235#ent", "pos": [11, 12]}}
{"token": ["In", "C0020538#ent", "<e1>", "the", "circulating", "C1414260#ent", "<e2>", "levels", "appear", "to", "be", "normal", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [1, 2]}, "relation": "disease_has_associated_gene", "t": {"id": "C1414260", "name": "C1414260#ent", "pos": [5, 6]}}
{"token": ["The", "cardiohemodynamic", "effects", "of", "a", "hypotensive", "agent", "SK&F", "24260", "and", "C0042402#ent", "<e1>", "diltiazem", ",", "dilazep", ",", "and", "C0041037#ent", "<e2>", ",", "and", "D", "600", "were", "studied", "in", "anesthetized", "open-chest", "dogs", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041037", "name": "C0041037#ent", "pos": [17, 18]}}
{"token": ["Both", "kindreds", "have", "essentially", "identical", "C0027697#ent", "<e1>", ";", "however", ",", "kindred", "P", "has", "C0018784#ent", "<e2>", "associated", "with", "C0027697#ent", "<e1>", ",", "while", "kindred", "C", "does", "not", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [13, 14]}}
{"token": ["These", "phosphorylations", "involve", "several", "signaling", "pathways", "including", "C0290178#ent", "<e1>", "MAP", "kinases", "and", "might", "require", "also", "the", "inhibition", "of", "the", "C1704708#ent", "<e2>"], "h": {"id": "C0290178", "name": "C0290178#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [19, 20]}}
{"token": ["Neurofibromatosis", "1", "NF1", ")", ",", "a", "genetic", "condition", "commonly", "characterized", "by", "the", "presence", "of", "dermal", "neurofibromas", "caf\u00e9", "au", "C0332573#ent", "<e1>", "has", "a", "significant", "impact", "on", "Quality", "of", "Life", "C0518214#ent", "<e2>", ")", "."], "h": {"id": "C0332573", "name": "C0332573#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0518214", "name": "C0518214#ent", "pos": [28, 29]}}
{"token": ["C0011875#ent", "<e1>", "a", "leading", "cause", "of", "acquired", "blindness", "C0022661#ent", "<e2>", "a", "variety", "of", "neuropathies", "and", "accelerated", "atherosclerosis", ",", "which", "could", "account", "for", "disabilities", "and", "high", "mortality", "rates", "patients", "with", "diabetes", "."], "h": {"id": "C0011875", "name": "C0011875#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [8, 9]}}
{"token": ["C0263888#ent", "<e1>", "most", "frequent", "among", "men", ",", "whereas", "C0009326#ent", "<e2>", "back", "disorders", "accounted", "for", "one-third", "of", "the", "cases", "among", "women", "."], "h": {"id": "C0263888", "name": "C0263888#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [8, 9]}}
{"token": ["Leukopenia", ",", "left", "ventricular", "hypertrabeculation/noncompaction", "(", "LVHT", ")", ",", "cardiomyopathy", ",", "and", "C0206157#ent", "<e1>", "are", "the", "clinical", "characteristics", "C0574083#ent", "<e2>", "BS", ")", "."], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0574083", "name": "C0574083#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "mCPP-induced", "C0020456#ent", "<e1>", "was", "dose", "dependently", "diminished", "by", "the", "C3536867#ent", "<e2>", "hexamethonium", "and", "was", "prevented", "by", "prior", "adrenodemedullation", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536867", "name": "C3536867#ent", "pos": [12, 13]}}
{"token": ["An", "investigation", "of", "renin", "genes", "enzymatic", "activity", "wild-derived", "mice", "identified", "several", "restriction", "site", "polymorphisms", "as", "well", "as", "putative", "variants", "in", "C0035094#ent", "<e1>", "expression", "and", "C0175168#ent", "<e2>"], "h": {"id": "C0035094", "name": "C0035094#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [24, 25]}}
{"token": ["Intriguingly", ",", "the", "amino-terminal", "half", "C3538890#ent", "<e1>", "as", "well", "as", "that", "of", "Tob", "was", "associated", "with", "human", "C1334043#ent", "<e2>", "of", "yeast", "Caf1", ",", "a", "component", "of", "the", "CCR4", "transcription", "factor", "complex"], "h": {"id": "C3538890", "name": "C3538890#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}}
{"token": ["Congenital", "GCTs", ",", "on", "the", "other", "hand", ",", "were", "negative", "for", "S100", "and", "C1880904#ent", "<e1>", "but", "positive", "for", "C1418544#ent", "<e2>", ",", "CD68", ",", "and", "vimentin", "."], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418544", "name": "C1418544#ent", "pos": [18, 19]}}
{"token": ["We", "show", "that", "sTfR", "release", "is", "mediated", "by", "an", "C1622401#ent", "<e1>", "can", "be", "inhibited", "by", "matrix", "metalloproteinase", "inhibitor", "2", "tumor", "necrosis", "factor", "alpha", "protease", "inhibitor-2", "C0389500#ent", "<e2>", ")", "."], "h": {"id": "C1622401", "name": "C1622401#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0389500", "name": "C0389500#ent", "pos": [25, 26]}}
{"token": ["We", "studied", "23", "patients", "with", "suspected", "C0020544#ent", "<e1>", "including", "12", "with", "C0035067#ent", "<e2>", "or", "occlusion", "."], "h": {"id": "C0020544", "name": "C0020544#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035067", "name": "C0035067#ent", "pos": [11, 12]}}
{"token": ["This", "study", "investigated", "the", "microvascular", "changes", "that", "affect", "vascular", "resistance", "the", "rat", "small", "intestine", "two-kidney", ",", "one", "C0020544#ent", "<e1>", "weeks", "after", "C0035067#ent", "<e2>"], "h": {"id": "C0020544", "name": "C0020544#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035067", "name": "C0035067#ent", "pos": [21, 22]}}
{"token": ["C0020544#ent", "<e1>", "left", "ventricular", "hypertrophy", "induced", "by", "unilateral", "nephrectomy", "C0035067#ent", "<e2>"], "h": {"id": "C0020544", "name": "C0020544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035067", "name": "C0035067#ent", "pos": [9, 10]}}
{"token": ["C1955862#ent", "<e1>", "K(ATP", ")", "channels", ")", "are", "heteromultimers", "of", "sulfonylurea", "receptors", "C0038880#ent", "<e2>", ")", "and", "inwardly", "rectifying", "potassium", "channel", "subunits", "K(IR)6.x", ")", "with", "a", "(", "SUR-K(IR)6.x)4", "stoichiometry", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [11, 12]}}
{"token": ["Cefazolin", ",", "cefoperazone-sulbactam", ",", "and/or", "levofloxacin", "were", "mostly", "administered", "to", "the", "patients", ",", "but", "these", "C0991617#ent", "<e1>", "seemed", "ineffective", "for", "eradication", "of", "C0648141#ent", "<e2>", "producers", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0648141", "name": "C0648141#ent", "pos": [22, 23]}}
{"token": ["In", "general", ",", "ECD", "spectra", "of", "synthetic", "and", "native", "C0031684#ent", "<e1>", "appeared", "less", "complex", "than", "conventional", "collision", "activated", "dissociation", "(", "C1504769#ent", "<e2>", ")", "mass", "spectra", "these", "species", "."], "h": {"id": "C0031684", "name": "C0031684#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [20, 21]}}
{"token": ["The", "validation", "data", "showed", "that", "the", "assay", "is", "sensitive", ",", "specific", "and", "reproducible", "for", "determination", "of", "C0700483#ent", "<e1>", ",", "ritonavir", "and", "C0674432#ent", "<e2>", "."], "h": {"id": "C0700483", "name": "C0700483#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0674432", "name": "C0674432#ent", "pos": [21, 22]}}
{"token": ["Available", "experimental", "and", "clinical", "data", "selective", "COX-2", "inhibitors", "including", "C0117885#ent", "<e1>", ",", "celecoxib", "or", "C0762662#ent", "<e2>", ",", "suggest", "improved", "gastric", "tolerance", "compared", "to", "conventional", ",", "non-selective", "NSAIDs", "."], "h": {"id": "C0117885", "name": "C0117885#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0762662", "name": "C0762662#ent", "pos": [14, 15]}}
{"token": ["A", "52-year-old", "man", "was", "diagnosed", "as", "having", "a", "variant", "of", "C0242292#ent", "<e1>", "the", "following", "findings", ":", "polyostotic", "fibrous", "dysplasia", "C0001206#ent", "<e2>", "due", "to", "pituitary", "tumor", "subclinical", "hyperthyroidism", "to", "toxic", "multinodular", "goiter"], "h": {"id": "C0242292", "name": "C0242292#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [19, 20]}}
{"token": ["An", "11-year-old", "girl", ",", "with", "the", "C0242292#ent", "<e1>", "exhibited", "fibrous", "dysplasia", "several", "bones", ",", "skin", "pigmentation", "precocious", "puberty", "growth", "hormone", "hypersecretion", "C0001206#ent", "<e2>", "and", "hyper-prolactinemia", "."], "h": {"id": "C0242292", "name": "C0242292#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [21, 22]}}
{"token": ["The", "association", "of", "the", "C0242292#ent", "<e1>", "polyostotic", "fibrous", "dysplasia", "bone", ",", "hyperpigmented", "skin", "macules", "and", "endocrine", "disorders", "with", "C0001206#ent", "<e2>", "has", "been", "infrequently", "substantiated", "."], "h": {"id": "C0242292", "name": "C0242292#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [18, 19]}}
{"token": ["Sixteen", "colts", "were", "premedicated", "with", "C0000960#ent", "<e1>", "and", "anaesthesia", "was", "induced", "with", "detomidine", "and", "C0022614#ent", "<e2>", "."], "h": {"id": "C0000960", "name": "C0000960#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [14, 15]}}
{"token": ["Polarization", "required", "PI3K", "the", "guanine", "nucleotide", "exchange", "factor", "Vav1", ",", "the", "GTP-binding", "protein", "C0082645#ent", "<e1>", ",", "as", "well", "as", "C1334539#ent", "<e2>"], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [19, 20]}}
{"token": ["The", "most", "common", "AKI", "causes", "are", "secondary", ",", "such", "as", "C0036690#ent", "<e1>", ",", "nephrotoxic", "medication", "and", "ischemia", ",", "each", "leading", "to", "acute", "tubular", "necrosis", "C0268494#ent", "<e2>", ")", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268494", "name": "C0268494#ent", "pos": [24, 25]}}
{"token": ["We", "conclude", "that", "in", "the", "population", "sampled", ",", "there", "was", "no", "association", "between", "the", "C0002085#ent", "<e1>", "the", "ACE", "gene", "the", "risk", "of", "developing", "C0017661#ent", "<e2>", "in", "NIDDM", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [23, 24]}}
{"token": ["In", "vivo", "C0242706#ent", "<e1>", "challenge", "induced", "p21-dependent", "differentiation", "of", "C0015674#ent", "<e2>", "to", "myofibroblasts", "in", "the", "infarct", "boundary", "region", "of", "ischemia-reperfused", "heart"], "h": {"id": "C0242706", "name": "C0242706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [9, 10]}}
{"token": ["In", "47", "patients", "with", "various", "pituitary", "tumours", "plasma", "cortisol", ",", "LH", ",", "C0016424#ent", "<e1>", ",", "prolactin", ",", "and", "C1333673#ent", "<e2>", "were", "measured", "by", "radioimmunoassays", "to", "investigate", "anterior", "pituitary", "function"], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [18, 19]}}
{"token": ["Similar", "results", "were", "obtained", "with", "a", "combination", "of", "C1333673#ent", "<e1>", "and", "C0016424#ent", "<e2>", "or", "C1333673#ent", "<e1>", "and", "testosterone", ",", "although", "C1333673#ent", "<e1>", "alone", "had", "no", "effect", "testicular", "IGF-I", "concentrations", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [8, 9]}}
{"token": ["The", "extent", "of", "methylation", "of", "Hpall-Mspl", "and", "Hhal", "sites", "in", "C0011522#ent", "<e1>", "isolated", "from", "normal", "rat", "livers", "and", "from", "the", "transplantable", "hepatocellular", "carcinomas", "C0039663#ent", "<e2>", ")", "C0039663#ent", "<e2>", "7777", "and", "C0039663#ent", "<e2>", "252", "was", "compared", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039663", "name": "C0039663#ent", "pos": [23, 24]}}
{"token": ["Whereas", "administration", "of", "C1161331#ent", "<e1>", "to", "starved", "C0020676#ent", "<e2>", "rats", "consistently", "induced", "the", "Hss-1", "and", "Hss-2", "sites", ",", "T3", "consistently", "induced", "all", "three", "DNase", "I-hypersensitive", "sites", "."], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [7, 8]}}
{"token": ["Alteration", "of", "C1418208#ent", "<e1>", "did", "not", "significantly", "decrease", "repression", "of", "either", "C0022895#ent", "<e2>", "."], "h": {"id": "C1418208", "name": "C1418208#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [11, 12]}}
{"token": ["C0016719#ent", "<e1>", "F.A.", ")", "is", "a", "C1285162#ent", "<e2>", "commonly", "leads", "to", "premature", "death", "cardiorespiratory", "origin"], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [6, 7]}}
{"token": ["C0016719#ent", "<e1>", "FA", ")", "is", "a", "progressive", ",", "multisystem", ",", "C1285162#ent", "<e2>", "by", "a", "reduction", "in", "frataxin", "."], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [10, 11]}}
{"token": ["C0016719#ent", "<e1>", "FA", ")", "is", "a", "progressive", ",", "C1285162#ent", "<e2>", "which", "oxidative", "stress", "believed", "to", "have", "a", "role", "."], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [8, 9]}}
{"token": ["C0016719#ent", "<e1>", "FRDA", ")", "is", "an", "autosomal", "recessive", "C1285162#ent", "<e2>", "primarily", "affects", "the", "nervous", "system", "heart", "."], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [8, 9]}}
{"token": ["Affinity-crosslinking", "studies", "revealed", "that", "five", "of", "nine", "B", "cell", "lines", "expressed", "C1705582#ent", "<e1>", "and", "p75", "without", "detectable", "Tac", "antigen", "C0599295#ent", "<e2>", ")", "expression", "and", "the", "expression", "was", "associated", "with", "B", "cell", "."], "h": {"id": "C1705582", "name": "C1705582#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [19, 20]}}
{"token": ["By", "using", "anti-phosphotyrosine", "antibodies", "to", "immunoprecipitate", "affinity-labeled", "IL-2", "receptors", "to", "probe", "Western", "blots", "we", "provide", "data", "suggesting", "that", "C1705582#ent", "<e1>", ",", "but", "not", "C0599295#ent", "<e2>", ",", "is", "constitutively", "tyrosine-phosphorylated", "on", "the", "leukemic", "cell", "lines", "."], "h": {"id": "C1705582", "name": "C1705582#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [23, 24]}}
{"token": ["Long-term", "C0242350#ent", "<e1>", "patients", "display", "a", "broad", "heterogeneity", "in", "C1328053#ent", "<e2>", "expression", "and", "nitrinergic", "innervation", "no", "overall", "correlation", "between", "NOS", "expression", "and", "erectile", "function", "observed", "."], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [9, 10]}}
{"token": ["Since", "1879", "when", "C0029291#ent", "<e1>", "was", "recognized", "as", "a", "C0029896#ent", "<e2>", "cases", "have", "been", "reported", "in", "North", "and", "South", "America", "Europe", ",", "Asia", ",", "and", "Australia", "."], "h": {"id": "C0029291", "name": "C0029291#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [9, 10]}}
{"token": ["Prader-Willi", "syndrome", "PWS", ")", "is", "an", "example", "of", "a", "human", "genetic", "disorder", "involves", "imprinting", "genes", "the", "proximal", "long", "arm", "of", "chromosome", "15", "and", "C1420295#ent", "<e1>", "a", "candidate", "gene", "for", "this", "C1848862#ent", "<e2>", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [30, 31]}}
{"token": ["We", "searched", "for", "C0017337#ent", "<e1>", "upregulated", "by", "thymosin", "beta4", "identified", "C1421874#ent", "<e2>", "as", "increased", "in", "SiHa", "cells", "in", "the", "presence", "of", "exogenously", "added", "thymosin", "beta4", "when", "thymosin", "beta4", "overexpressed", "using", "adenoviral", "vectors"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421874", "name": "C1421874#ent", "pos": [10, 11]}}
{"token": ["S-phase", "kinase-associated", "protein", "2", "C1335831#ent", "<e1>", ")", ",", "a", "member", "of", "the", "F-box", "family", "of", "C1256818#ent", "<e2>", "controls", "the", "stability", "of", "cell", "cycle-related", "proteins", "p27Kip1", "."], "h": {"id": "C1335831", "name": "C1335831#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1256818", "name": "C1256818#ent", "pos": [15, 16]}}
{"token": ["Skp1", ",", "together", "with", "F-box", "proteins", "C1335831#ent", "<e1>", ",", "are", "part", "of", "C1256818#ent", "<e2>", "target", "many", "cell", "cycle", "regulators", "ubiquitination-mediated", "proteolysis"], "h": {"id": "C1335831", "name": "C1335831#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1256818", "name": "C1256818#ent", "pos": [12, 13]}}
{"token": ["The", "C1562036#ent", "<e1>", "nimodipine", "and", "dantrolene", "were", "compared", "with", "C0012010#ent", "<e2>", "in", "an", "animal", "model", "tolerance", "and", "physical", "dependence", "ethanol", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [9, 10]}}
{"token": ["The", "hypothermic", "effect", "of", "C1839163#ent", "<e1>", "was", "unaffected", "by", "NO-328", "but", "enhanced", "by", "C0016375#ent", "<e2>", ",", "albeit", "only", "at", "doses", "higher", "than", "those", "needed", "to", "potentiate", "THC-induced", "catalepsy", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016375", "name": "C0016375#ent", "pos": [13, 14]}}
{"token": ["The", "Chr", "6", "C3826857#ent", "<e1>", "is", "in", "the", "same", "region", "as", "a", "highly", "significant", "C0242383#ent", "<e2>", "C3826857#ent", "<e1>", "found", "previously", "."], "h": {"id": "C3826857", "name": "C3826857#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [14, 15]}}
{"token": ["Previously", ",", "several", "quantitative", "trait", "loci", "C3826857#ent", "<e1>", ")", "that", "influence", "C0242383#ent", "<e2>", "ageRD", ")", "were", "demonstrated", "in", "a", "cross", "between", "the", "C57BL/6J-c(2J", ")", "and", "BALB/cByJ", "strains", "(", "B", "x", "C", ")", "."], "h": {"id": "C3826857", "name": "C3826857#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", "we", "generated", "a", "mouse", "model", "deficient", "in", "SM2", "myosin", "C0597298#ent", "<e1>", "but", "expressing", "C1866993#ent", "<e2>", ",", "using", "an", "exon-specific", "gene", "strategy", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1866993", "name": "C1866993#ent", "pos": [16, 17]}}
{"token": ["It", "is", "suggested", "that", "these", "results", "could", "have", "relevance", "for", "the", "use", "of", "C0021246#ent", "<e1>", "as", "an", "anti-inflammatory", "agent", "C0003873#ent", "<e2>"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["Uveitis", "has", "advantages", "for", "studying", "the", "pathogenetic", "mechanisms", "of", "C1290884#ent", "<e1>", "by", "HTLV-1", ",", "since", "observation", "of", "the", "C0027721#ent", "<e2>", "relatively", "easy", "and", "clinical", "samples", "the", "lesion", "can", "be", "obtained", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [18, 19]}}
{"token": ["To", "elucidate", "the", "involvement", "of", "the", "classical", "and/or", "the", "C2346907#ent", "<e1>", "pathway", "during", "C0684256#ent", "<e2>", "32", "patients", "with", "gram-positive", "and", "30", "patients", "with", "gram-negative", "bacterial", "infections", "investigated", "."], "h": {"id": "C2346907", "name": "C2346907#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0684256", "name": "C0684256#ent", "pos": [13, 14]}}
{"token": ["Symptoms", "of", "pulmonary", "TB", "a", "cough", "with", "or", "without", "sputum", "production", "at", "least", "three", "weeks", ",", "chest", "pain", "C0019079#ent", "<e1>", ",", "fever", ",", "night", "sweats", "weight", "loss", "lack", "of", "appetite", "chills", "and", "C0427055#ent", "<e2>", "."], "h": {"id": "C0019079", "name": "C0019079#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [32, 33]}}
{"token": ["Examples", "of", "C0034494#ent", "<e1>", "in", "foxes", "and", "C0016514#ent", "<e2>", "cattle", "suggest", "that", "theory", "can", "be", "used", "to", "guide", "the", "design", "of", "vaccination", "programmes", "."], "h": {"id": "C0034494", "name": "C0034494#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0016514", "name": "C0016514#ent", "pos": [7, 8]}}
{"token": ["We", "conclude", "that", "increased", "antifibrinolytic", "activity", "to", "both", "C1418253#ent", "<e1>", "antiplasmins", "in", "the", "bronchoalveolar", "compartment", "patients", "with", "C0035222#ent", "<e2>", "contributes", "to", "the", "formation", "and", "persistence", "of", "hyaline", "membranes", "a", "key", "component", "of", "alveolar", "histopathology", "C0035222#ent", "<e2>", "."], "h": {"id": "C1418253", "name": "C1418253#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [17, 18]}}
{"token": ["IL-17", ",", "a", "product", "of", "T", "lymphocytes", "has", "proinflammatory", "effects", "induces", "production", "of", "C1334706#ent", "<e1>", "such", "as", "C0166027#ent", "<e2>", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0166027", "name": "C0166027#ent", "pos": [17, 18]}}
{"token": ["As", "affected", "fetuses", "with", "infantile", "Refsum's", "disease", "C0043459#ent", "<e1>", "no", "significant", "elevation", "of", "C0282526#ent", "<e2>", "their", "surrounding", "amniotic", "fluids", "the", "measurement", "of", "C0282526#ent", "<e2>", "amniotic", "fluid", "not", "to", "be", "useful", "for", "prenatal", "diagnosis", "these", "disorders", "."], "h": {"id": "C0043459", "name": "C0043459#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0282526", "name": "C0282526#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "myocardial", "adaptation", "ischemia", "inhibited", "the", "ischemia", "reperfusion-induced", "loss", "of", "C1709127#ent", "<e1>", "from", "the", "nucleus", ",", "which", "was", "inhibited", "by", "antisense", "C0140145#ent", "<e2>", "."], "h": {"id": "C1709127", "name": "C1709127#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [23, 24]}}
{"token": ["EPM2A", "is", "predicted", "to", "encode", "a", "putative", "C0085536#ent", "<e1>", "its", "specific", "role", "in", "normal", "brain", "function", "in", "the", "C0751783#ent", "<e2>", "not", "known", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751783", "name": "C0751783#ent", "pos": [18, 19]}}
{"token": ["Aleurone", "layers", "not", "previously", "exposed", "to", ")", "or", "C0001477#ent", "<e1>", "qualitative", "and", "quantitative", "changes", "in", "C1334064#ent", "<e2>", "production", "following", "incubation", "in", "either", "GA(3", ")", "or", "C0001477#ent", "<e1>", "both", "."], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [8, 9]}}
{"token": ["C0700450#ent", "<e1>", "is", "a", "C0039052#ent", "<e2>", "was", "designed", "as", "an", "inotropic", "agent", "use", "in", "congestive", "heart", "failure"], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [4, 5]}}
{"token": ["The", "availability", "of", "dopamine", "and", "C0700450#ent", "<e1>", "and", "the", "possibility", "of", "combined", "use", "of", "C0039052#ent", "<e2>", "a", "broad", "spectrum", "of", "haemodynamic", "effects", "for", "therapy", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [14, 15]}}
{"token": ["C0700450#ent", "<e1>", "is", "a", "C0039052#ent", "<e2>", "beta", "1", "agonist", "that", "increases", "myocardial", "contractility", "at", "high", "doses", "systolic", "arterial", "blood", "pressure", "heart", "rate"], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [4, 5]}}
{"token": ["C0700450#ent", "<e1>", "is", "a", "C0039052#ent", "<e2>", "which", "can", "be", "used", "in", "patients", "with", "dilated", "cardiomyopathy", "DCM", ")", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [4, 5]}}
{"token": ["Finally", ",", "C1416991#ent", "<e1>", "has", "appeared", "to", "regulate", "C1334117#ent", "<e2>", "influencing", "apoptosis-related", "mechanisms", "."], "h": {"id": "C1416991", "name": "C1416991#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334117", "name": "C1334117#ent", "pos": [8, 9]}}
{"token": ["Symptoms", "of", "C0085696#ent", "<e1>", "similar", "to", "those", "of", "C1720797#ent", "<e2>", "include", "low", "back", "pain", "frequency", ",", "dysuria", ",", "perineal", "discomfort", "and", "painful", "ejaculation"], "h": {"id": "C0085696", "name": "C0085696#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1720797", "name": "C1720797#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "the", "expression", "of", "Omi/HtrA2", "in", "the", "spermatozoa", "of", "C0085696#ent", "<e1>", "patients", "and", "explore", "the", "potential", "mechanism", "of", "C1720797#ent", "<e2>", "male", "infertility", "."], "h": {"id": "C0085696", "name": "C0085696#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1720797", "name": "C1720797#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "whether", "C0065374#ent", "<e1>", ",", "an", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitor", ",", "and", "C0053355#ent", "<e2>", ",", "an", "aminopeptidase", "inhibitor", "broad", "specificity", ",", "could", "affect", "collagen", "production", "in", "control", "and", "transforming", "growth", "factor", "cardiac", "fibroblasts"], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0053355", "name": "C0053355#ent", "pos": [14, 15]}}
{"token": ["These", "included", "patients", "with", "C0403414#ent", "<e1>", "lower", "urinary", "tract", "infection", "severe", "reflux", "nephropathy", "lithium", "induced", "nephropathy", ",", "C3149841#ent", "<e2>", "familiar", "benign", "haematuria", ",", "and", "renal", "graft", "rejection"], "h": {"id": "C0403414", "name": "C0403414#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [17, 18]}}
{"token": ["Immunoreactivities", "for", "C1334508#ent", "<e1>", ",", "LIS1", "and", "vimentin", "in", "C0043459#ent", "<e2>", "were", "comparable", "to", "those", "of", "controls", "."], "h": {"id": "C1334508", "name": "C1334508#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [9, 10]}}
{"token": ["Studies", "to", "characterize", "the", "function", "of", "these", "C1417374#ent", "<e1>", "have", "used", "C4284022#ent", "<e2>", "from", "MARCO", "or", "SR-AI/II", "null", "mice", "but", "this", "approach", "is", "limited", "by", "the", "relatively", "low", "yield", "of", "C4284022#ent", "<e2>", "."], "h": {"id": "C1417374", "name": "C1417374#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284022", "name": "C4284022#ent", "pos": [11, 12]}}
{"token": ["Five", "male", "patients", "with", "C0024535#ent", "<e1>", "Plasmodium", "vivax", "infections", "infused", "with", "C0055447#ent", "<e2>", "15", "mg", "kg-1", ")", "over", "four", "hours", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0055447", "name": "C0055447#ent", "pos": [11, 12]}}
{"token": ["Some", "evidence", "indicated", "that", "canonical", "elements", "internally", "deleted", "copies", "are", "recent", "acquisitions", "of", "Drosophila", "C0017428#ent", "<e1>", ",", "while", "the", "\"", "relics", "\"", "are", "C1136365#ent", "<e2>", "normally", "degenerated", "and", "immobile", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [23, 24]}}
{"token": ["We", "also", "show", "that", "the", "C1425986#ent", "<e1>", "the", "hydrolysis", "of", "various", "phenolic", "(", "e.g.", "arbutin", "and", "C0073969#ent", "<e2>", ")", "and", "cyanogenic", "plant", "glucosides", "e.g.", "prunasin", ")", "."], "h": {"id": "C1425986", "name": "C1425986#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0073969", "name": "C0073969#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "show", "that", "although", "C0018304#ent", "<e1>", "is", "able", "to", "inhibit", "prostaglandin", "biosynthesis", "a", "classic", "C3536840#ent", "<e2>", ",", "it", "does", "not", "induce", "gastric", "damage"], "h": {"id": "C0018304", "name": "C0018304#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536840", "name": "C3536840#ent", "pos": [15, 16]}}
{"token": ["C0132555#ent", "<e1>", "activity", "is", "decreased", "in", "patients", "with", "C0600040#ent", "<e2>"], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0600040", "name": "C0600040#ent", "pos": [8, 9]}}
{"token": ["We", "attempted", "to", "determine", "whether", "oral", "L-arginine", ",", "the", "substrate", "for", "C0132555#ent", "<e1>", "increases", "C0132555#ent", "<e1>", "and", "cyclic", "guanosine", "monophosphate", "cGMP", ")", "levels", "in", "the", "urine", "from", "C0600040#ent", "<e1>", "patients", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0600040", "name": "C0600040#ent", "pos": [27, 28]}}
{"token": ["The", "recovery", "time", "C0039925#ent", "<e1>", "was", "markedly", "longer", "in", "the", "presence", "of", "the", "C0003286#ent", "<e2>", "17.0", "min", "v.", "37.1", "min", ")", "."], "h": {"id": "C0039925", "name": "C0039925#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "examined", "mitotic", "radial", "glial", "lineage", "cells", "the", "rat", "brain", "E17-P7", ",", "using", "the", "monoclonal", "antibody", "4A4", "which", "recognizes", "C1421451#ent", "<e1>", "phosphorylated", "by", "a", "mitosis-specific", "kinase", "C0081947#ent", "<e2>"], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0081947", "name": "C0081947#ent", "pos": [27, 28]}}
{"token": ["We", "previously", "described", "a", "unique", "syndrome", "of", "optic", "atrophy", "sensorineural", "hearing", "loss", "ptosis", ",", "and", "C0029089#ent", "<e1>", "in", "two", "unrelated", "families", "associated", "with", "R445H", "mutation", "in", "C3273878#ent", "<e2>", "."], "h": {"id": "C0029089", "name": "C0029089#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3273878", "name": "C3273878#ent", "pos": [26, 27]}}
{"token": ["Group", "VII", "C3812677#ent", "<e1>", "was", "performed", "on", "day", "5", "without", "C4049878#ent", "<e2>", "."], "h": {"id": "C3812677", "name": "C3812677#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4049878", "name": "C4049878#ent", "pos": [10, 11]}}
{"token": ["In", "addition", "to", "C0011777#ent", "<e1>", ",", "other", "anti-inflammatory", "steroids", "increased", "C2697550#ent", "<e2>", "the", "order", "of", "their", "glucocorticoid", "activity"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697550", "name": "C2697550#ent", "pos": [10, 11]}}
{"token": ["C0011777#ent", "<e1>", "induced", "the", "expression", "of", "C2697550#ent", "<e2>", "in", "a", "time-", "and", "concentration-dependent", "manner", "in", "A549", "human", "lung", "adenocarcinoma", "cells"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697550", "name": "C2697550#ent", "pos": [6, 7]}}
{"token": ["Moreover", ",", "the", "positive", "interactions", "between", "C3541401#ent", "<e1>", "and", "farnesyltransferase", "inhibitors", "KIT", "receptor", "tyrosine", "kinase", "inhibitors", "e.g.", "imatinib", "mesylate", ")", "and", "C0085387#ent", "<e2>", "discussed", "in", "relation", "to", "their", "potential", "synergistic", "and", "additive", "effects"], "h": {"id": "C3541401", "name": "C3541401#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [21, 22]}}
{"token": ["The", "presence", "of", "the", "a1a2", "domain", "greatly", "enhanced", "C1334905#ent", "<e1>", ",", "but", "not", "C1705321#ent", "<e2>", "binding", "to", "b1b2", "."], "h": {"id": "C1334905", "name": "C1334905#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705321", "name": "C1705321#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "combined", "therapy", "G-CSF", "and", "C1366564#ent", "<e1>", "may", "improve", "the", "C0023530#ent", "<e2>", "and", "anemia", "of", "AIDS", "."], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [13, 14]}}
{"token": ["C0872913#ent", "<e1>", "and", "B-cells", "deficient", "in", "C0001414#ent", "<e2>", "enzyme", "activity", "cloned", "from", "peripheral", "blood", "mononuclear", "cells", "a", "selecting", "agent", ",", "2,6-diaminopurine", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001414", "name": "C0001414#ent", "pos": [6, 7]}}
{"token": ["To", "address", "this", "issue", ",", "we", "cloned", ",", "from", "human", "peripheral", "blood", "C0872913#ent", "<e1>", "and", "B-cells", "with", "mutations", "at", "an", "C0001414#ent", "<e2>", "APRT", ")", "locus", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001414", "name": "C0001414#ent", "pos": [20, 21]}}
{"token": ["Tumors", "containing", "chromosomes", "with", "partial", "LOH", "have", "allowed", "improved", "localization", "of", "Loh1", "to", "a", "region", "of", "approximately", "3.2", "centiMorgans", "on", "chromosome", "9", "C1419895#ent", "<e1>", "with", "human", "C0795809#ent", "<e2>", "15q", "."], "h": {"id": "C1419895", "name": "C1419895#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0795809", "name": "C0795809#ent", "pos": [26, 27]}}
{"token": ["Plasma", "C3273406#ent", "<e1>", "not", "decreased", "by", "either", "trandolapril", "or", "C0020223#ent", "<e2>", "when", "administered", "in", "combination", "with", "isoproterenol", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [9, 10]}}
{"token": ["Role", "of", "inspiratory", "muscle", "function", "the", "C4255166#ent", "<e1>", "of", "dyspnea", "in", "C3714496#ent", "<e2>", "patients", "has", "yet", "to", "be", "fully", "studied", "."], "h": {"id": "C4255166", "name": "C4255166#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3714496", "name": "C3714496#ent", "pos": [11, 12]}}
{"token": ["A", "40", "year", "old", "man", "admitted", "with", "prolonged", "fever", ",", "C0745091#ent", "<e1>", ",", "increased", "serum", "levels", "cholestasis", "enzymes", "and", "low", "density", "masses", "the", "hepatic", "computed", "tomography", "C3813556#ent", "<e2>", ")", "."], "h": {"id": "C0745091", "name": "C0745091#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [26, 27]}}
{"token": ["Pharmacologic", "inhibitors", "matrix", "metalloproteinases", "MMP", ")", "and", "of", "a", "disintegrin", "and", "metalloproteases", "(", "C1314771#ent", "<e1>", ")", ",", "and", "the", "C1420705#ent", "<e2>", "metalloproteinase-3", ",", "significantly", "inhibited", "sALCAM", "release", "by", "EOC", "cells", "."], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420705", "name": "C1420705#ent", "pos": [19, 20]}}
{"token": ["It", "seems", "probable", "that", "C0042749#ent", "<e1>", "induces", "changes", "in", "distribution", "volume", "and/or", "gastrointestinal", "absorption", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [15, 16]}}
{"token": ["Six", "healthy", "adult", "males", "were", "studied", "to", "evaluate", "the", "effect", "of", "C0003596#ent", "<e1>", "on", "growth", "hormone", "GH", ")", "secretion", "under", "normoglycaemic", "and", "C0020456#ent", "<e2>", "conditions", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [22, 23]}}
{"token": ["We", "studied", "the", "origin", "of", "the", "neutrophil-activating", "peptide", "C1705594#ent", "<e1>", ",", "a", "presumed", "70", "amino", "acid", "product", "of", "platelet", "basic", "protein", "C1418599#ent", "<e2>", ")", "and", "connective", "tissue-activating", "peptide", "III", "CTAP-III", ")", "."], "h": {"id": "C1705594", "name": "C1705594#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418599", "name": "C1418599#ent", "pos": [21, 22]}}
{"token": ["IRS-CAAX", "migrated", "more", "slowly", "on", "sodium", "dodecyl", "sulfate-polyacrylamide", "gel", "electrophoresis", "did", "C1704984#ent", "<e1>", "and", "demonstrated", "increased", "levels", "of", "C1414387#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C1704984", "name": "C1704984#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [18, 19]}}
{"token": ["We", "have", "identified", "eight", "Schizosaccharomyces", "pombe", "cDNAs", "that", ",", "when", "C3889446#ent", "<e1>", ",", "suppress", "the", "HS-sensitive", "phenotype", "associated", "with", "deletion", "of", "C1539940#ent", "<e2>", "in", "S.", "cerevisiae"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539940", "name": "C1539940#ent", "pos": [21, 22]}}
{"token": ["Ewing's", "sarcoma", "associated", "with", "fusion", "between", "the", "EWS", "and", "C0808900#ent", "<e1>", "genes", ",", "forming", "an", "C3274608#ent", "<e2>"], "h": {"id": "C0808900", "name": "C0808900#ent", "pos": [9, 10]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274608", "name": "C3274608#ent", "pos": [15, 16]}}
{"token": ["The", "C0751785#ent", "<e1>", "EPM1", ")", "and", "autoimmune", "polyglandular", "disease", "type", "I", "(", "C0085859#ent", "<e2>", ")", "have", "been", "mapped", "to", "human", "chromosome", "21q22.3", "genetic", "linkage", "analysis", "linkage", "disequilibrium", "studies"], "h": {"id": "C0751785", "name": "C0751785#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085859", "name": "C0085859#ent", "pos": [12, 13]}}
{"token": ["In", "normal", "hearts", ",", "increased", "stimulation", "frequency", "increases", "force", ",", "but", "in", "C0018801#ent", "<e1>", "HF", ")", "this", "force-frequency", "relationship", "(", "C1412871#ent", "<e2>", ")", "is", "often", "flattened", "or", "reversed", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412871", "name": "C1412871#ent", "pos": [20, 21]}}
{"token": ["C2744579#ent", "<e1>", "hydrolysis", "is", "unaffected", "by", "the", "addition", "of", "either", "C0120541#ent", "<e2>", "DNA", "but", "stimulated", "in", "the", "presence", "of", "both", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0120541", "name": "C0120541#ent", "pos": [10, 11]}}
{"token": ["Upon", "stimulation", ",", "TLR", "recruits", "a", "cytoplasmic", "adaptor", "molecule", "MyD88", ",", "then", "IL-IR-associated", "kinase", "(", "C1334134#ent", "<e1>", ")", ",", "and", "finally", "induces", "activation", "of", "NF-kappaB", "and", "C0752312#ent", "<e2>"], "h": {"id": "C1334134", "name": "C1334134#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [26, 27]}}
{"token": ["Two", "dissimilar", "diuretic", "agents", "studied", ":", "the", "C3536860#ent", "<e1>", "mannitol", ";", "and", "the", "C0012798#ent", "<e2>", "ethacrynic", "acid"], "h": {"id": "C3536860", "name": "C3536860#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [13, 14]}}
{"token": ["It", "is", "possible", "that", "the", "C0026848#ent", "<e1>", "is", "due", "to", "perturbations", "in", "C0027096#ent", "<e2>", "mRNA", "expression", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [12, 13]}}
{"token": ["These", "diabetes", "associated", "susceptibility", "traits", "include", "C1850380#ent", "<e1>", "abnormal", "cross-linking", "and", "glycosylation", "of", "C0009325#ent", "<e2>", ",", "defective", "secretion", "of", "growth", "factors", "subsequent", "impaired", "healing", "."], "h": {"id": "C1850380", "name": "C1850380#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "rats", "fed", "C0917900#ent", "<e1>", "a", "significantly", "reduced", "incidence", "of", "the", "C0027707#ent", "<e2>", "observed", "in", "older", "rats"], "h": {"id": "C0917900", "name": "C0917900#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027707", "name": "C0027707#ent", "pos": [13, 14]}}
{"token": ["C1427155#ent", "<e1>", "alone", "caused", "no", "detectable", "increase", "in", "receptor", "C0085536#ent", "<e2>", "content", "."], "h": {"id": "C1427155", "name": "C1427155#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [9, 10]}}
{"token": ["Eflornithine", "(", "C0002260#ent", "<e1>", ";", "DFMO", ")", "is", "a", "recently", "developed", "drug", "against", "C0041228#ent", "<e2>", "sleeping", "sickness", "."], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0041228", "name": "C0041228#ent", "pos": [13, 14]}}
{"token": ["The", "C2984597#ent", "<e1>", "family", "of", "C1947941#ent", "<e2>", "are", "type", "I", "transmembrane", "proteins", "both", "metalloproteinase", "and", "disintegrin", "containing", "extracellular", "domains"], "h": {"id": "C2984597", "name": "C2984597#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [5, 6]}}
{"token": ["In", "Caenorhabditis", "elegans", "genetic", "evidence", "implicated", "SUP-17", ",", "the", "ortholog", "of", "Drosophila", "C2984597#ent", "<e1>", "and", "mammalian", "ADAM10", ",", "as", "the", "C1947941#ent", "<e2>", "that", "mediates", "this", "event", "."], "h": {"id": "C2984597", "name": "C2984597#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [20, 21]}}
{"token": ["These", "C0599220#ent", "<e1>", "were", "sensitive", "to", "C0962754#ent", "<e2>", "treatment", "which", "reduced", "the", "Mr", "to", "20", "kDa", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [6, 7]}}
{"token": ["Both", "pretreatment", "of", "6-shogaol", "(", "6S", ")", "and", "C0061267#ent", "<e1>", "(", "6", "G", ")", "significantly", "inhibited", "the", "tumor", "necrosis", "factor-alpha", "C1710304#ent", "<e2>", ")", "mediated", "downregulation", "of", "the", "adiponectin", "expression", "in", "3T3-L1", "adipocytes", "."], "h": {"id": "C0061267", "name": "C0061267#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [20, 21]}}
{"token": ["The", "use", "of", "C0002403#ent", "<e1>", "for", "the", "prevention", "and", "early", "treatment", "C0021400#ent", "<e2>", "selected", "situations", "merits", "serious", "consideration", ",", "provided", "the", "diagnosis", "is", "made", "sufficiently", "early", "."], "h": {"id": "C0002403", "name": "C0002403#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [11, 12]}}
{"token": ["Circulating", "hormones", "like", "angiotensin", "II", "C1337111#ent", "<e1>", "which", "are", "released", "in", "response", "to", "C0020625#ent", "<e2>", "adrenalectomy", ",", "could", "regulate", "the", "activity", "of", "Na+", "channels", "through", "G-protein", "linked", "second-messenger", "systems"], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [13, 14]}}
{"token": ["C0019202#ent", "<e1>", "be", "taken", "into", "consideration", "in", "case", "of", "any", "C0023895#ent", "<e2>", "unknown", "origin", "or", "neuropsychiatric", "symptoms", "."], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "C0080298#ent", "<e1>", "the", "activity", "of", "C1259877#ent", "<e2>", "intercellular", "communication", "been", "studied", "in", "transformed", "NIH/3T3", "clones", "isolated", "from", "soft", "agar", "transfection", "with", "the", "plasmid", "carrying", "the", "v-src", "gene", "psrc-11", ")", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [8, 9]}}
{"token": ["This", "was", "found", "whether", "the", "latter", "was", "increased", "by", "injection", "of", "tetraethyl", "ammonium", "TEA", ")", "into", "the", "C0702216#ent", "<e1>", "of", "C1335635#ent", "<e2>", "or", "decreased", "by", "hyperpolarization", "of", "the", "C0702216#ent", "<e1>", "of", "C1335635#ent", "<e2>", "."], "h": {"id": "C1335635", "name": "C1335635#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0702216", "name": "C0702216#ent", "pos": [17, 18]}}
{"token": ["C0042568#ent", "<e1>", "result", "in", "giddiness", ",", "transient", "C0745413#ent", "<e2>", "and", "drop", "attacks"], "h": {"id": "C0042568", "name": "C0042568#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0745413", "name": "C0745413#ent", "pos": [7, 8]}}
{"token": ["Here", "we", "show", "that", "treatment", "of", "mesangial", "cells", "AGEs", "and", "with", "the", "receptor", "for", "AGEs", "agonist", "C3274824#ent", "<e1>", "triggers", "activation", "of", "the", "extracellular", "signal-regulated", "kinase", "ERK", ")", "and", "C0044602#ent", "<e2>", "PI3", "K", ")", "pathways", "."], "h": {"id": "C3274824", "name": "C3274824#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [28, 29]}}
{"token": ["We", "have", "studied", "the", "expression", "of", "MIIB2", "in", "renal", "biopsy", "samples", "from", "patients", "with", "various", "C0012634#ent", "<e1>", "in", "the", "renal", "tissues", "the", "rat", "model", "of", "C0221238#ent", "<e2>", "induced", "with", "anti-Thy", "1.1", "antibody"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0221238", "name": "C0221238#ent", "pos": [25, 26]}}
{"token": ["HCLP-1", "selectively", "interacts", "with", "C1413703#ent", "<e1>", "but", "not", "with", "C0733688#ent", "<e2>", "."], "h": {"id": "C1413703", "name": "C1413703#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0733688", "name": "C0733688#ent", "pos": [9, 10]}}
{"token": ["Therefore", ",", "the", "roles", "of", "the", "two", "C0026794#ent", "<e1>", ",", "NMT1", "and", "NMT2", ",", "in", "myristoylating", "Gag", "and", "C0017356#ent", "<e2>", "were", "examined", "using", "biochemical", "and", "molecular", "approaches"], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017356", "name": "C0017356#ent", "pos": [18, 19]}}
{"token": ["Amantadine", "and", "memantine", "are", "in", "clinical", "use", "the", "treatment", "of", "C0524851#ent", "<e1>", "as", "M.", "Parkinson", "and", "C0853695#ent", "<e2>"], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0853695", "name": "C0853695#ent", "pos": [16, 17]}}
{"token": ["The", "amino", "acid", "sequence", "xanthine", "dehydrogenase", "R.", "capsulatus", "showed", "a", "higher", "degree", "of", "similarity", "to", "C1421531#ent", "<e1>", "to", "the", "C0001985#ent", "<e2>", "Desulphovibrio", "gigas"], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001985", "name": "C0001985#ent", "pos": [19, 20]}}
{"token": ["Catecholamine", "perfusion", "caused", "a", "weak", "nonsignificant", "increase", "in", "phase-2", "VPB", ",", "VT", "and", "VF", "incidence", ",", "but", "there", "was", "no", "C0003195#ent", "<e1>", "interaction", "with", "C0086303#ent", "<e2>", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [20, 21]}, "relation": "therapeutic_class_of", "t": {"id": "C0086303", "name": "C0086303#ent", "pos": [24, 25]}}
{"token": ["Moricizine", "seems", "to", "be", "better", "tolerated", "than", "quinidine", ",", "disopyramide", ",", "and", "imipramine", "and", "to", "have", "less", "C0003195#ent", "<e1>", "potential", "than", "C0086303#ent", "<e2>", "or", "encainide", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [17, 18]}, "relation": "therapeutic_class_of", "t": {"id": "C0086303", "name": "C0086303#ent", "pos": [21, 22]}}
{"token": ["C0022020#ent", "<e1>", "treatment", "alone", "was", "sufficient", "to", "upregulate", "the", "expression", "of", "C1424503#ent", "<e2>", "mRNA", "isoform", "transcribed", "from", "the", "proximal", "promoter", "."], "h": {"id": "C0022020", "name": "C0022020#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424503", "name": "C1424503#ent", "pos": [11, 12]}}
{"token": ["Higher", "constitutive", "expression", "of", "C0061505#ent", "<e1>", "could", "potentially", "contribute", "to", "the", "C0242912#ent", "<e2>", "seen", "in", "female", "mouse", "following", "exposure", "to", "neurotoxins", ",", "such", "as", "MPTP", "."], "h": {"id": "C0061505", "name": "C0061505#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [11, 12]}}
{"token": ["The", "higher", "constitutive", "expression", "of", "glutathione", "reductase", "C0061505#ent", "<e1>", "could", "potentially", "confer", "C0242912#ent", "<e2>", "to", "female", "mice"], "h": {"id": "C0061505", "name": "C0061505#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [12, 13]}}
{"token": ["BT-GMZ", "bound", "to", "purified", "yeast", "HSP82", "(", "homologue", "to", "mammalian", "C3273510#ent", "<e1>", ")", "and", "EEF1A1", ",", "but", "not", "to", "C1417503#ent", "<e2>", "or", "HBS1", ",", "and", "was", "competed", "by", "unlabeled", "gamendazole", "."], "h": {"id": "C3273510", "name": "C3273510#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417503", "name": "C1417503#ent", "pos": [19, 20]}}
{"token": ["DP1", "is", "a", "C0907533#ent", "<e1>", "expressed", "protein", ",", "whereas", "C1705438#ent", "<e2>", "is", "mainly", "expressed", "at", "the", "G(1)/S", "boundary", "of", "the", "cell", "cycle"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705438", "name": "C1705438#ent", "pos": [9, 10]}}
{"token": ["We", "show", "here", "that", "cells", "C0907533#ent", "<e1>", "expressing", "a", "mutant", "C1705438#ent", "<e2>", "E2F1d87", ")", "produce", "reduced", "amounts", "of", "fibronectin", "mRNA", "and", "protein", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705438", "name": "C1705438#ent", "pos": [10, 11]}}
{"token": ["We", "analyzed", "the", "effects", "of", "dietary", "fish", "oil", "C0015695#ent", "<e1>", "induced", "by", "C1161331#ent", "<e2>", ",", "safflower", "oil", "and", "butter", "in", "ddY", "mice", "."], "h": {"id": "C0015695", "name": "C0015695#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [12, 13]}}
{"token": ["A", "marked", "fatty", "liver", "when", "the", "homozygous", "mutant", "Zucker", "rat", "(", "ff", "or", "\"", "C0015695#ent", "<e1>", "\"", ")", "is", "fed", "a", "semisynthetic", "diet", "enriched", "in", "C1161331#ent", "<e2>", "."], "h": {"id": "C0015695", "name": "C0015695#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [25, 26]}}
{"token": ["Young", "male", "pigs", "consumed", "a", "diet", "of", "C0015695#ent", "<e1>", "minced", "beef", ",", "safflower", "oil", "skim", "milk", "powder", ",", "C1161331#ent", "<e2>", ",", "cornstarch", "and", "wheat", "bran"], "h": {"id": "C0015695", "name": "C0015695#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [18, 19]}}
{"token": ["Whereas", "C1826709#ent", "<e1>", "is", "predominantly", "involved", "in", "the", "maturation", "of", "C0020284#ent", "<e2>", "HybF", "takes", "over", "its", "function", "in", "the", "maturation", "of", "isoenzymes", "1", "2", "."], "h": {"id": "C1826709", "name": "C1826709#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020284", "name": "C0020284#ent", "pos": [10, 11]}}
{"token": ["Chlorpromazine", ",", "C0040979#ent", "<e1>", "and", "3,4,5-trimethoxybenzoic", "acid", "8-(diethylamino)octyl", "ester", "antagonised", "the", "effect", "of", "C0256103#ent", "<e2>", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [13, 14]}}
{"token": ["Stimulation", "of", "the", "phosphorylation", "of", "26", "K", "is", "also", "induced", "by", "the", "Ca2", "+", "-ionophore", "A23187", ",", "but", "the", "calmodulin", "inhibitor", "C0040979#ent", "<e1>", "does", "not", "inhibit", "the", "C0256103#ent", "<e2>", "induced", "stimulation", "of", "polypeptide", "phosphorylation"], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [27, 28]}}
{"token": ["C0022661#ent", "<e1>", "CRF", ")", "is", "one", "of", "the", "most", "common", "C0679247#ent", "<e2>", "of", "geriatric", "cats"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0679247", "name": "C0679247#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "transient", "overexpression", "of", "C1414316#ent", "<e1>", "C8161-c9", "cells", "resulted", "in", "a", "loss", "of", "C1332729#ent", "<e2>", "interleukin-8", "promoter", "activities", "protein", "expression"], "h": {"id": "C1414316", "name": "C1414316#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332729", "name": "C1332729#ent", "pos": [14, 15]}}
{"token": ["Salivary", "gland", "agenesis", "cause", "profound", "xerostomia", "in", "children", "and", "there", "may", "be", "oral", "and", "upper", "respiratory", "tract", "sequelae", ",", "such", "as", "C0011334#ent", "<e1>", "candidiasis", ",", "ascending", "sialadenitis", "laryngitis", "and", "C0001344#ent", "<e2>", "."], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0001344", "name": "C0001344#ent", "pos": [29, 30]}}
{"token": ["C1815010#ent", "<e1>", "confirmed", "a", "significant", "effect", "on", "C0010054#ent", "<e2>", "systemic", "hypertension"], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [7, 8]}}
{"token": ["The", "cardioprotection", "observed", "with", "C1815010#ent", "<e1>", "is", "greater", "than", "that", "provided", "by", "beta-adrenoceptor", "antagonists", ",", "suggesting", "that", "the", "additional", "activities", "of", "C1815010#ent", "<e1>", "may", "provide", "benefit", "in", "the", "setting", "of", "C0010054#ent", "<e1>"], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [30, 31]}}
{"token": ["An", "improvement", "of", "left-ventricular", "function", "also", "obtained", "on", "administration", "of", "C1815010#ent", "<e1>", "in", "patients", "with", "C0010054#ent", "<e2>"], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [15, 16]}}
{"token": ["The", "beta-blocker", "C1815010#ent", "<e1>", "has", "been", "shown", "to", "induce", "vasodilation", "in", "patients", "with", "C0010054#ent", "<e2>"], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [13, 14]}}
{"token": ["However", ",", "this", "PMA", "response", "was", "strongly", "inhibited", "by", "calmodulin", "antagonists", "chlorpromazine", ",", "trifluoperazine", ",", "C0078437#ent", "<e1>", ")", "and", "the", "calcium", "blocker", "C0042523#ent", "<e2>", "."], "h": {"id": "C0078437", "name": "C0078437#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [22, 23]}}
{"token": ["These", "results", "are", "suggestive", "of", "a", "new", "role", "for", "autoantigens", "in", "the", "pathogenesis", "of", "C0018213#ent", "<e1>", "that", "of", "inducing", "the", "expression", "of", "C0669372#ent", "<e2>", "and", "activating", "the", "monocyte", "possibly", "underlying", "the", "autoimmune", "response"], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [22, 23]}}
{"token": ["It", "is", "usually", "caused", "by", "C0037036#ent", "<e1>", "from", "a", "tumor", ",", "ulcer", ",", "or", "C0024214#ent", "<e2>"], "h": {"id": "C0037036", "name": "C0037036#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024214", "name": "C0024214#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "whether", "genetic", "variation", "the", "C1416902#ent", "<e1>", "related", "to", "the", "occurrence", "of", "C1867743#ent", "<e2>"], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1867743", "name": "C1867743#ent", "pos": [13, 14]}}
{"token": ["Allelic", "frequencies", "polymorphic", "variants", "at", "the", "C1416902#ent", "<e1>", "been", "measured", "in", "subjects", "with", "C1867743#ent", "<e2>", "dyslipidaemia", "."], "h": {"id": "C1416902", "name": "C1416902#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1867743", "name": "C1867743#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "treatment", "of", "cells", "with", "C1417807#ent", "<e1>", "dibutyryl", "cGMP", ",", "8-bromo-cGMP", ",", "C1414404#ent", "<e2>", "or", "NaNO3", "failed", "to", "significantly", "alter", "the", "affinity", "or", "number", "of", "[125I]-angiotensin", "II", "binding", "sites", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414404", "name": "C1414404#ent", "pos": [14, 15]}}
{"token": ["A", "recently", "generated", "aSmase", "knock-out", "mouse", "line", "a", "lethal", "C0267971#ent", "<e1>", "mimics", "the", "neurovisceral", "form", "of", "C0268242#ent", "<e2>", "man", "."], "h": {"id": "C0267971", "name": "C0267971#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0268242", "name": "C0268242#ent", "pos": [16, 17]}}
{"token": ["Transgenic", "mice", "carried", "the", "mutant", "form", "of", "the", "C0085151#ent", "<e1>", "expressed", "high", "concentrations", "of", "mutant", "copy", "of", "the", "C0079429#ent", "<e2>", "and", "exhibited", "abundant", "amyloid", "plaques", "in", "the", "brain", "and", "memory", "loss"], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}}
{"token": ["The", "C0085151#ent", "<e1>", "a", "small", "fragment", "of", "a", "membrane-associated", "glycoprotein", "encoded", "by", "a", "C0079429#ent", "<e2>", "on", "human", "chromosome", "21", "which", "is", "telomeric", "to", "a", "genetic", "defect", "causes", "at", "least", "some", "cases", "of", "familial", "Alzheimer's", "disease"], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["C1333196#ent", "<e1>", "pretreatment", "of", "mTEC", "cultures", "and", "Vero", "cells", "that", "rWSN", "NS1", "C1822897#ent", "<e2>", "is", "more", "sensitive", "to", "the", "presence", "of", "antiviral/inflammatory", "cytokines", "wild-type", "virus"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1822897", "name": "C1822897#ent", "pos": [12, 13]}}
{"token": ["Antagonism", "by", "C1517662#ent", "<e1>", "was", "increased", "by", "1", "and", "10", "microM", "C0029904#ent", "<e2>", ",", "yielding", "6.5-", "and", "10.5-fold", "shifts", "to", "the", "right", "of", "the", "serotonin", "CRC", ",", "respectively", "."], "h": {"id": "C1517662", "name": "C1517662#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [11, 12]}}
{"token": ["Primary", "hypobetalipoproteinemia", "HBL", ")", "includes", "a", "group", "of", "genetic", "disorders", "abetalipoproteinemia", "(", "ABL", ")", "and", "C0795956#ent", "<e1>", "CRD", ")", ",", "with", "a", "recessive", "transmission", "and", "C0020597#ent", "<e2>", "FHBL", ")", "with", "a", "co-dominant", "transmission", "."], "h": {"id": "C0795956", "name": "C0795956#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0020597", "name": "C0020597#ent", "pos": [25, 26]}}
{"token": ["In", "spite", "of", "daily", "1.5", "micrograms", "calcitriol", "treatment", "and", "phosphate", "supplementation", "C0020631#ent", "<e1>", "persisted", "for", "13", "years", "and", "he", "needed", "regular", "C0030082#ent", "<e2>", "medication", "for", "his", "bone", "pain"], "h": {"id": "C0020631", "name": "C0020631#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030082", "name": "C0030082#ent", "pos": [21, 22]}}
{"token": ["The", "entire", "3.5", "kb", "C3889703#ent", "<e1>", "efficiently", "recombined", "into", "a", "target", "C0149678#ent", "<e2>", "vector", "lacking", "lacZ", "sequences", "but", "having", "limited", "homology", "to", "the", "donor", "plasmid"], "h": {"id": "C3889703", "name": "C3889703#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [11, 12]}}
{"token": ["The", "effector", "and", "catalytic", "proteins", "C1414998#ent", "<e1>", "associated", "in", "presence", "of", "acidic", "phospholipid", "give", "active", "C0027203#ent", "<e2>", "."], "h": {"id": "C1414998", "name": "C1414998#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["The", "stomach", "C1412336#ent", "<e1>", "isozymes", "exhibited", "a", "Km", "value", "C0030438#ent", "<e2>", "of", "75", "mM", ",", "and", "an", "optimum", "for", "C0030438#ent", "<e2>", "oxidation", "at", "pH", "8.5", "."], "h": {"id": "C1412336", "name": "C1412336#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030438", "name": "C0030438#ent", "pos": [9, 10]}}
{"token": ["Escherichia", "coli", "HU", "protein", "as", "a", "heterodimer", "composed", "of", "two", "highly", "homologous", "subunits", "HU-1", "and", "C1419743#ent", "<e1>", ",", "encoded", "by", "the", "C0063034#ent", "<e2>", "and", "hupA", "genes", ",", "respectively", "."], "h": {"id": "C1419743", "name": "C1419743#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0063034", "name": "C0063034#ent", "pos": [21, 22]}}
{"token": ["RECQL4", "(", "C1433276#ent", "<e1>", "was", "identified", "as", "a", "fourth", "member", "of", "the", "human", "C1335609#ent", "<e2>", "bearing", "the", "helicase", "domain", "and", "it", "was", "subsequently", "shown", "to", "be", "the", "responsible", "gene", "in", "Rothmund-Thomson", "syndrome"], "h": {"id": "C1433276", "name": "C1433276#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335609", "name": "C1335609#ent", "pos": [13, 14]}}
{"token": ["Three", "had", "C0027796#ent", "<e1>", "AN", ")", "and", "8", "patients", "had", "postherpetic", "neuralgia", "C1424662#ent", "<e2>", ")", "."], "h": {"id": "C0027796", "name": "C0027796#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424662", "name": "C1424662#ent", "pos": [12, 13]}}
{"token": ["To", "gain", "insight", "into", "the", "potential", "subfield", "and", "laminar-specific", "expression", "of", "GP", ",", "histochemistry", "can", "be", "used", "to", "evaluate", "C0082645#ent", "<e1>", "GPa", ")", "or", "totalGP", "(", "GPa", "+", "C3490329#ent", "<e2>", ")", "."], "h": {"id": "C0082645", "name": "C0082645#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3490329", "name": "C3490329#ent", "pos": [28, 29]}}
{"token": ["The", "authors", "tested", "the", "hypothesis", "that", "C1846414#ent", "<e1>", "GABA(A", ")", ")", "and", "strychnine-sensitive", "glycine", "receptor", "systems", "mediate", "C0018549#ent", "<e2>", "depression", "of", "spinal", "sensory", "responses", "to", "noxious", "stimuli", "."], "h": {"id": "C1846414", "name": "C1846414#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [17, 18]}}
{"token": ["In", "conclusion", ",", "this", "study", "suggests", "that", "C1420593#ent", "<e1>", "might", "possess", "protective", "effects", "inflammation-", "and", "oxidative", "C0524851#ent", "<e2>"], "h": {"id": "C1420593", "name": "C1420593#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524851", "name": "C0524851#ent", "pos": [16, 17]}}
{"token": ["Defective", "ATGL", "function", "causes", "a", "recessively", "inherited", "disorder", "named", "C0268238#ent", "<e1>", "is", "characterized", "by", "systemic", "TG", "accumulation", "and", "C0026848#ent", "<e2>", "."], "h": {"id": "C0268238", "name": "C0268238#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [18, 19]}}
{"token": ["In", "a", "hospital", "for", "neurological", "rehabilitation", "have", "performed", "an", "open", "study", "the", "effects", "of", "SSRI", ",", "C0070122#ent", "<e1>", ",", "in", "depressive", "disorders", "by", "C0042075#ent", "<e2>"], "h": {"id": "C0070122", "name": "C0070122#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [23, 24]}}
{"token": ["We", "propose", "that", "redox", "environment", "regulates", "hydrogenase", "'s", "affinity", "for", "C1415944#ent", "<e1>", "(", "and", "likely", "C1419394#ent", "<e2>", "as", "well", ")", "."], "h": {"id": "C1415944", "name": "C1415944#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419394", "name": "C1419394#ent", "pos": [15, 16]}}
{"token": ["The", "hydrogenase", "will", "catalyze", "a", "low", "rate", "of", "exchange", "in", "the", "reaction", "between", "C1415944#ent", "<e1>", "and", "H2O", "to", "form", "both", "HD", "and", "C1419394#ent", "<e2>", "."], "h": {"id": "C1415944", "name": "C1415944#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1419394", "name": "C1419394#ent", "pos": [22, 23]}}
{"token": ["Synovial", "fluids", "C0876942#ent", "<e1>", ")", "contain", "inhibitors", "capable", "of", "neutralizing", "the", "activity", "of", "C1947941#ent", "<e2>", "secreted", "by", "inflammatory", "cells", "fibroblasts", "."], "h": {"id": "C0876942", "name": "C0876942#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [13, 14]}}
{"token": ["Sex", "determination", "mammalian", "C0018050#ent", "<e1>", "depends", "on", "the", "concerted", "action", "of", "C0949635#ent", "<e2>", "and", "SOX", "at", "the", "genital", "ridge"], "h": {"id": "C0018050", "name": "C0018050#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0949635", "name": "C0949635#ent", "pos": [11, 12]}}
{"token": ["Those", "given", "the", "C0036457#ent", "<e1>", "agent", "developed", "clinical", "signs", "C3714552#ent", "<e2>", ",", "posterior", "ataxia", "and", "emaciation", "after", "incubated", "periods", "of", "8", "to", "23", "months", "."], "h": {"id": "C0036457", "name": "C0036457#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [9, 10]}}
{"token": ["To", "further", "investigate", "C1335207#ent", "<e1>", "functions", "in", "tumor", "growth", "metastasis", "formation", ",", "we", "used", "transgenic", "mice", "overexpressing", "C1335207#ent", "<e1>", "in", "the", "skin", "under", "the", "control", "of", "the", "C0669391#ent", "<e1>", "promoter", "."], "h": {"id": "C1335207", "name": "C1335207#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669391", "name": "C0669391#ent", "pos": [27, 28]}}
{"token": ["This", "group", "of", "organisms", "is", "also", "implicated", "in", "the", "pathogenesis", "of", "C1956346#ent", "<e1>", "well", "as", "C0029408#ent", "<e2>", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [15, 16]}}
{"token": ["C0068788#ent", "<e1>", "(", "NTZ", ")", "and", "its", "deacetylated", "metabolite", "tizoxanide", "(", "C1538238#ent", "<e2>", ")", "are", "nitro-thiazolyl-salicylamide", "drugs", "with", "a", "broad-spectrum", "anti-parasitic", "activity", "in", "vitro", "in", "vivo"], "h": {"id": "C0068788", "name": "C0068788#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1538238", "name": "C1538238#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "C1839163#ent", "<e1>", "by", "heparin", "therapy", "not", "rare", ",", "and", "C0048470#ent", "<e2>", "as", "an", "anticoagulant", "during", "off-pump", "CABG", "is", "thought", "to", "be", "useful", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0048470", "name": "C0048470#ent", "pos": [12, 13]}}
{"token": ["Glial", "cells", "fibroblasts", "(", "C1426940#ent", "<e1>", ")", "play", "a", "key", "role", "in", "epiretinal", "membrane", "C1414477#ent", "<e2>", ")", "development", "and", "progression", "."], "h": {"id": "C1426940", "name": "C1426940#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414477", "name": "C1414477#ent", "pos": [14, 15]}}
{"token": ["We", "have", "previously", "reported", "that", "C1881340#ent", "<e1>", "EGCg", ")", "inhibited", "lung", "carcinoma", "cell", "adhesion", "fibronectin", "(", "C1706331#ent", "<e2>", ")", "and", "demonstrated", "its", "interaction", "with", "C1706331#ent", "<e2>", "."], "h": {"id": "C1881340", "name": "C1881340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [16, 17]}}
{"token": ["C0004235#ent", "<e1>", "is", "a", "new", "non-depolarising", "neuromuscular", "blocking", "agent", "C0025517#ent", "<e2>", "through", "Hofmann", "elimination", "."], "h": {"id": "C0004235", "name": "C0004235#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}}
{"token": ["In", "patients", "with", "spinal", "cord", "injuries", "having", "frequent", "C0262655#ent", "<e1>", "complicated", "pathophysiological", "conditions", "urinary", "C1842690#ent", "<e2>", "is", "one", "of", "the", "helpful", "laboratory", "findings", "for", "the", "diagnosis", "of", "acute", "pyelonephritis"], "h": {"id": "C0262655", "name": "C0262655#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1842690", "name": "C1842690#ent", "pos": [14, 15]}}
{"token": ["Serum", "levels", "C0054340#ent", "<e1>", ",", "its", "principal", "metabolite", "270C81", ")", "and", "C0042671#ent", "<e2>", "were", "measured", "during", "the", "study", "."], "h": {"id": "C0054340", "name": "C0054340#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042671", "name": "C0042671#ent", "pos": [11, 12]}}
{"token": ["A", "DNA", "cassette", "three", "copies", "of", "green", "fluorescent", "protein", "3XGFP", ")", "was", "inserted", "in", "the", "C1335633#ent", "<e1>", "at", "codon", "D330", ")", "or", "the", "C1334871#ent", "<e2>", "at", "codon", "N321", ")", "."], "h": {"id": "C1335633", "name": "C1335633#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334871", "name": "C1334871#ent", "pos": [23, 24]}}
{"token": ["To", "assess", "whether", "the", "topical", "use", "of", "steroids", "or", "C0030125#ent", "<e1>", "5-ASA", ")", "is", "superior", "to", "C0038633#ent", "<e2>", "in", "preventing", "acute", "rectal", "toxicity", "during", "three-dimensional", "conformal", "radiotherapy", "3DCRT", ")", "to", "76", "Gy", "."], "h": {"id": "C0030125", "name": "C0030125#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038633", "name": "C0038633#ent", "pos": [16, 17]}}
{"token": ["C0003405#ent", "<e1>", "been", "widely", "used", "for", "the", "treatment", "of", "C0015371#ent", "<e2>", "a", "long", "time", "their", "pharmacological", "characterization", "has", "been", "unclear", "."], "h": {"id": "C0003405", "name": "C0003405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [9, 10]}}
{"token": ["From", "220", "necropsies", "of", "patients", "with", "cerebral", "infarcts", "5", "were", "selected", ",", "in", "which", "the", "clinical", "history", "typical", "C0003405#ent", "<e1>", "symptoms", "with", "a", "progressive", "course", "of", "the", "C0015371#ent", "<e2>"], "h": {"id": "C0003405", "name": "C0003405#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [27, 28]}}
{"token": ["Temperature", "block", "pulse-chase", ",", "and", "35S-sulfate-labelling", "experiments", "suggested", "that", "C1364818#ent", "<e1>", "is", "cleaved", "by", "C1364818#ent", "<e1>", "C0699919#ent", "<e1>", "intracellularly", "in", "the", "trans-Golgi", "network", "(", "TGN", ")", "or", "in", "a", "post-Golgi", "compartment", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [16, 17]}}
{"token": ["Finally", ",", "we", "observed", "that", "ERM", "bound", "TAFII60", "via", "C1705543#ent", "<e1>", "and", "bound", "C0077021#ent", "<e2>", "and", "TAFII40", ",", "presumably", "via", "other", "activation", "domains", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0077021", "name": "C0077021#ent", "pos": [13, 14]}}
{"token": ["2", ")", "When", "procaine", "was", "injected", "unilaterally", "into", "C0015230#ent", "<e1>", "the", "lumbar", "erector", "muscles", "of", "traumatic", "vertigo", "cases", ",", "C0028738#ent", "<e2>", "disturbances", "of", "the", "righting", "reflex", "decreased", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028738", "name": "C0028738#ent", "pos": [19, 20]}}
{"token": ["In", "addition", "to", "the", "previously", "known", "substrate", ",", "the", "Pol", "II", "CTD", "it", "was", "found", "that", "C1423887#ent", "<e1>", "phosphorylates", "two", "subunits", "of", "C0127400#ent", "<e2>", "and", "Srb10", "targets", "two", "subunits", "of", "TFIID", "for", "phosphorylation", "."], "h": {"id": "C1423887", "name": "C1423887#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [22, 23]}}
{"token": ["Gene", "ontology", "analysis", "cell", "cycle", "regulators", "be", "the", "predominant", "functional", "gene", "class", "in", "MB", "of", "C1826732#ent", "<e1>", "mutants", ",", "including", "D-type", "cyclins", "and", "C0246957#ent", "<e2>"], "h": {"id": "C1826732", "name": "C1826732#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0246957", "name": "C0246957#ent", "pos": [23, 24]}}
{"token": ["The", "C3539802#ent", "<e1>", "encodes", "the", "C0035547#ent", "<e2>", "RR", ")", "small", "subunit", "2", "homologue", ",", "and", "is", "induced", "by", "several", "stress", "signals", "activating", "p53", ",", "such", "as", "DNA-damaging", "agents", "."], "h": {"id": "C3539802", "name": "C3539802#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0035547", "name": "C0035547#ent", "pos": [5, 6]}}
{"token": ["The", "pathogens", "that", "cause", "Lyme", "disease", "C1539521#ent", "<e1>", ")", ",", "human", "anaplasmosis", ",", "and", "C0004576#ent", "<e2>", "can", "coexist", "in", "Ixodes", "ticks", "cause", "human", "coinfections", "."], "h": {"id": "C1539521", "name": "C1539521#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004576", "name": "C0004576#ent", "pos": [14, 15]}}
{"token": ["The", "C0017337#ent", "<e1>", "that", "may", "encode", "the", "alpha", "2A", "C1334080#ent", "<e2>", "and", "alpha", "2C", "subtypes", "have", "been", "identified", "in", "human", "and", "rat", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334080", "name": "C1334080#ent", "pos": [9, 10]}}
{"token": ["Packed", "red", "blood", "cells", "C0073385#ent", "<e1>", "Plasmanate", "and", "nutritional", "support", "C0724624#ent", "<e2>", "ketones", "by", "mouth", "and", "amino", "acids", "IV", "were", "given", "."], "h": {"id": "C0073385", "name": "C0073385#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [10, 11]}}
{"token": ["Tacrolimus", "(", "FK506", ")", "and", "cyclosporin", "A", "C0010592#ent", "<e1>", ")", "are", "two", "potent", "immunosuppressants", "mainly", "metabolized", "by", "C1142644#ent", "<e2>", "CYP3A", ")", "monooxygenase", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [7, 8]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [17, 18]}}
{"token": ["The", "C0159028#ent", "<e1>", "back", "pain", "patients", "with", "C0029458#ent", "<e2>", "back", "pain", "spinal", "deformity", "Type-2", "."], "h": {"id": "C0159028", "name": "C0159028#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [7, 8]}}
{"token": ["The", "results", "of", "these", "studies", "affirmed", "that", "unbound", "C0022322#ent", "<e1>", "is", "an", "inhibitor", "of", "the", "C1823242#ent", "<e2>", "efflux", "system", "BMECs", "."], "h": {"id": "C0022322", "name": "C0022322#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1823242", "name": "C1823242#ent", "pos": [15, 16]}}
{"token": ["In", "total", ",", "235", "children", "were", "evaluated", "(", "152", "receiving", "flunisolide", "C2674616#ent", "<e1>", ",", "39", "BDP", ",", "and", "44", "C0086073#ent", "<e2>", ")", "."], "h": {"id": "C2674616", "name": "C2674616#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086073", "name": "C0086073#ent", "pos": [19, 20]}}
{"token": ["More", "serious", "features", "of", "idiopathic", "lupus", "as", "nephritis", "and", "C0007774#ent", "<e1>", "rare", "in", "C0860207#ent", "<e2>"], "h": {"id": "C0007774", "name": "C0007774#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0860207", "name": "C0860207#ent", "pos": [13, 14]}}
{"token": ["However", ",", "in", "a", "2", "x", "2", "arrangement", "of", "C2697656#ent", "<e1>", "and", "C0025641#ent", "<e2>", ",", "1", "mg/kg", "C0025641#ent", "<e2>", "failed", "to", "increase", "food", "intake", "C2697656#ent", "<e1>", "and", "non-LPS-treated", "rats", "in", "two", "separate", "trials", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025641", "name": "C0025641#ent", "pos": [12, 13]}}
{"token": ["K(v", ")", "channel", "expression", "is", "decreased", "in", "C3203102#ent", "<e1>", ",", "leading", "to", "elevations", "of", "cytosolic", "K(+", ")", "and", "C0001477#ent", "<e2>", "impair", "apoptosis", "and", "increase", "proliferation", "."], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [18, 19]}}
{"token": ["When", "aminoglycosides", "or", "beta-lactam", "antibiotics", "ineffective", ",", "administration", "of", "C0991617#ent", "<e1>", "effective", "against", "C0023241#ent", "<e2>", "be", "considered", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023241", "name": "C0023241#ent", "pos": [13, 14]}}
{"token": ["1", "alpha,25(OH)(2)D", "is", "derived", "from", "its", "precursor", "25-hydroxyvitamin", "D", "the", "enzyme", "1", "alpha-hydroxylase", "by", "the", "C1413865#ent", "<e1>", "is", "inactivated", "by", "C3543418#ent", "<e2>", "encoded", "by", "the", "CYP24A1", "gene"], "h": {"id": "C1413865", "name": "C1413865#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3543418", "name": "C3543418#ent", "pos": [20, 21]}}
{"token": ["Co-expression", "of", "CYP2R1", "with", "vitamin", "D", "1alpha-hydroxylase", "C1413865#ent", "<e1>", ")", "elicited", "additive", "activation", "of", "vitamin", "D3", "whereas", "co-expression", "with", "C3543418#ent", "<e2>", "CYP24A1", ")", "caused", "inactivation", "."], "h": {"id": "C1413865", "name": "C1413865#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3543418", "name": "C3543418#ent", "pos": [19, 20]}}
{"token": ["Cutaneous", "or", "anal", "anomalies", "both", "have", "been", "reported", "in", "a", "number", "of", "syndromes", "associated", "with", "C0010278#ent", "<e1>", ",", "including", "Crouzon", ",", "Pfeiffer", ",", "Apert", ",", "and", "C1852406#ent", "<e2>"], "h": {"id": "C0010278", "name": "C0010278#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C1852406", "name": "C1852406#ent", "pos": [26, 27]}}
{"token": ["Of", "these", "C0235267#ent", "<e1>", "six", "had", "chronic", "glaucoma", "one", "had", "C0017605#ent", "<e2>", "first", "seen", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [10, 11]}}
{"token": ["The", "data", "indicate", "that", "in", "C.", "apella", "and", "M.", "mulatta", ",", "C0051739#ent", "<e1>", "is", "a", "relatively", "C0221777#ent", "<e2>", "antischistosomal", "agent", "effective", "orally", "against", "a", "broad", "spectrum", "of", "schistosome", "species"], "h": {"id": "C0051739", "name": "C0051739#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0221777", "name": "C0221777#ent", "pos": [16, 17]}}
{"token": ["Because", "calmodulin", "kinase", "C3541431#ent", "<e1>", ")", "can", "regulate", "C0872043#ent", "<e2>", "activity", ",", "C3541431#ent", "<e1>", "activity", "in", "renal", "cortical", "membranes", "of", "WKHA", "and", "WKHT", "were", "studied", "."], "h": {"id": "C3541431", "name": "C3541431#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0872043", "name": "C0872043#ent", "pos": [8, 9]}}
{"token": ["The", "C1450093#ent", "<e1>", "a", "member", "of", "the", "C1333195#ent", "<e2>", "is", "a", "major", "cause", "of", "primary", "congenital", "glaucoma", "PCG", ")", ",", "a", "rare", "and", "severely", "blinding", "disease", "recessive", "inheritance", "."], "h": {"id": "C1450093", "name": "C1450093#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333195", "name": "C1333195#ent", "pos": [7, 8]}}
{"token": ["Trimethoprim", "is", "an", "C0003204#ent", "<e1>", "in", "the", "treatment", "of", "urinary", "and", "C0041912#ent", "<e2>", "mild", "to", "moderate", "pneumocystis", "carinii", "pneumonia"], "h": {"id": "C0003204", "name": "C0003204#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [11, 12]}}
{"token": ["Unlike", "C0012694#ent", "<e1>", "ketotifen", "ameliorates", "the", "symptoms", "of", "asthma", ",", "rhinitis", "and", "C0011603#ent", "<e2>", "when", "present", "together", "in", "atopic", "patients", "."], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011603", "name": "C0011603#ent", "pos": [12, 13]}}
{"token": ["The", "ability", "of", "class", "I", "alcohol", "dehydrogenase", "C3810564#ent", "<e1>", ")", "and", "class", "IV", "alcohol", "dehydrogenase", "ADH4", ")", "to", "metabolize", "retinol", "to", "C0022265#ent", "<e2>", "supported", "by", "genetic", "studies", "mice", "carrying", "Adh1", "or", "Adh4", "gene", "."], "h": {"id": "C3810564", "name": "C3810564#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [21, 22]}}
{"token": ["A", "larger", "percentage", "of", "C0282556#ent", "<e1>", "women", "suffered", "from", "respiratory", "and", "C0042029#ent", "<e2>", "in", "the", "control", "group", "p", "<", "0.001", ")", "."], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [11, 12]}}
{"token": ["In", "the", "presence", "of", "C0046565#ent", "<e1>", "butyrate", ",", "but", "not", "C0000979#ent", "<e2>", ",", "addition", "further", "reduced", "gluconeogenesis", "."], "h": {"id": "C0046565", "name": "C0046565#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [10, 11]}}
{"token": ["Being", "a", "member", "of", "the", "family", "of", "ADAMs", "(", "\"", "a", "disintegrin", "and", "metalloproteinase", "\"", ")", ",", "metargidin", "(", "C1313290#ent", "<e1>", ")", "combines", "a", "C1334706#ent", "<e2>", "an", "RGD", "aminoacid", "sequence"], "h": {"id": "C1313290", "name": "C1313290#ent", "pos": [19, 20]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [24, 25]}}
{"token": ["The", "C0208462#ent", "<e1>", "this", "pathway", "in", "Saccharomyces", "cerevisiae", "designated", "C1335624#ent", "<e2>", ",", "was", "found", "to", "be", "identical", "to", "Arg82", ",", "a", "regulator", "of", "the", "transcriptional", "complex", "."], "h": {"id": "C0208462", "name": "C0208462#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335624", "name": "C1335624#ent", "pos": [9, 10]}}
{"token": ["Lotronex", "(", "C0291771#ent", "<e1>", "is", "a", "5-HT3", "receptor", "antagonist", "for", "the", "treatment", "of", "C0022104#ent", "<e2>", "IBS", ")", "in", "females", "whose", "predominant", "bowel", "habit", "diarrhea", "."], "h": {"id": "C0291771", "name": "C0291771#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "define", "a", "new", "C0101555#ent", "<e1>", "step", "of", "splicing", "that", "is", "catalyzed", "by", "C1413955#ent", "<e2>", "."], "h": {"id": "C0101555", "name": "C0101555#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413955", "name": "C1413955#ent", "pos": [14, 15]}}
{"token": ["The", "C3887967#ent", "<e1>", "with", "c-Jun", "and", ",", "strikingly", ",", "with", "C0087140#ent", "<e2>", "to", "stimulate", "the", "transcription", "of", "both", "synthetic", "and", "natural", "reporter", "genes", "an", "AP-1", "site", "."], "h": {"id": "C3887967", "name": "C3887967#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [10, 11]}}
{"token": ["We", "studied", "the", "effect", "of", "C1414262#ent", "<e1>", "and", "ETB", "C2936804#ent", "<e2>", "PPE-1", "transcription", "both", "in", "vitro", "in", "vivo"], "h": {"id": "C1414262", "name": "C1414262#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936804", "name": "C2936804#ent", "pos": [9, 10]}}
{"token": ["Second", ",", "inhibition", "of", "BCR/ABL", "kinase", "activity", "with", "the", "C1268567#ent", "<e1>", "STI571", "rapidly", "increases", "C1332737#ent", "<e2>", "levels", "."], "h": {"id": "C1268567", "name": "C1268567#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [14, 15]}}
{"token": ["We", "have", "characterized", "a", "novel", "dominant", "C0002085#ent", "<e1>", "of", "the", "sex-determining", "gene", "her-1", "C0949990#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0949990", "name": "C0949990#ent", "pos": [13, 14]}}
{"token": ["These", "constructs", "generate", "single-stranded", ",", "inverted", "repeat", "C0242965#ent", "<e1>", ",", "with", "a", "wt", "C1366449#ent", "<e2>", "at", "each", "end", ",", "and", "a", "mutated", "C1366449#ent", "<e2>", "in", "the", "middle", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366449", "name": "C1366449#ent", "pos": [13, 14]}}
{"token": ["The", "function", "of", "the", "transcription", "factor", "myocyte", "enhancer", "factor-2", "C0059037#ent", "<e1>", ")", "is", "required", "for", "mediating", "membrane", "depolarization-dependent", "C1420257#ent", "<e2>"], "h": {"id": "C0059037", "name": "C0059037#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [18, 19]}}
{"token": ["The", "C1305923#ent", "<e1>", "the", "amino-terminal", "regulatory", "domain", "of", "C1706586#ent", "<e2>", "(", "residues", "1", "-", "257", ")", "are", "shown", "to", "interact", ",", "directly", "in", "vitro", "in", "a", "yeast", "expression", "system", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [8, 9]}}
{"token": ["C0017920#ent", "<e1>", "GSD", ")", "is", "a", "rare", "autosomal-recessive", "disorder", "by", "C0020615#ent", "<e2>", ",", "hepatosplenomegaly", ",", "seizures", ",", "and", "failure", "to", "thrive", "in", "infants", "."], "h": {"id": "C0017920", "name": "C0017920#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [10, 11]}}
{"token": ["C0006983#ent", "<e1>", "is", "a", "useful", "C0279175#ent", "<e2>", "a", "rare", "potentially", "fatal", "complication", "of", "agranulocytosis", "."], "h": {"id": "C0006983", "name": "C0006983#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0279175", "name": "C0279175#ent", "pos": [5, 6]}}
{"token": ["The", "C3537142#ent", "<e1>", "role", "of", "C0178469#ent", "<e2>", "drugs", "remains", "controversial", ";", "in", "isolated", "hearts", "they", "work", "in", "high", "concentrations", "not", "through", "specific", "receptor", "antagonism", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0178469", "name": "C0178469#ent", "pos": [5, 6]}}
{"token": ["The", "nucleotide", "sequence", "a", "4161", "bp", "DNA", "fragment", "the", "C1419336#ent", "<e1>", "determined", ",", "revealing", "an", "C0079941#ent", "<e2>", "2991", "nucleotides", "that", "encodes", "a", "protein", "of", "106,927", "Da", "."], "h": {"id": "C1419336", "name": "C1419336#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}}
{"token": ["To", "identify", "genes", "regulated", "by", "C0812287#ent", "<e1>", ",", "subtraction", "of", "whole", "embryo", "cDNA", "was", "carried", "out", "between", "C1883559#ent", "<e2>", "N-myc-deficient", "mutant", "mice", "."], "h": {"id": "C0812287", "name": "C0812287#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [17, 18]}}
{"token": ["Long-term", "treatment", "with", "valproate", "(", "VPA", ")", "or", "carbamazepine", "(", "CBZ", ")", "may", "induce", "C0236099#ent", "<e1>", "patients", "with", "C0014547#ent", "<e2>", "."], "h": {"id": "C0236099", "name": "C0236099#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [18, 19]}}
{"token": ["Recently", ",", "topical", "application", "C0064870#ent", "<e1>", "--", "a", "potent", "H1", "antagonist", "yielded", "good", "clinical", "results", "allergic", "conjunctivitis", "C0009766#ent", "<e2>", "and", "non", "allergic", "rhinitis", "."], "h": {"id": "C0064870", "name": "C0064870#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [17, 18]}}
{"token": ["Depletion", "of", "C0968598#ent", "<e1>", "also", "inhibits", "C0164786#ent", "<e2>", "and", "JNK", "activation", "."], "h": {"id": "C0968598", "name": "C0968598#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [6, 7]}}
{"token": ["Candidate", "C0085249#ent", "<e1>", "selected", "based", "on", "homology", "to", "other", "known", "C1333828#ent", "<e2>", "two", "T-DNA", "knockout", "lines", "flavonol-3-O-rhamnoside-7-O-rhamnosides", "(", "ugt78D1", ")", "and", "quercetin-3-O-rhamnoside-7-O-glucoside", "(", "ugt73C6", "and", "ugt78D1", ")", "were", "identified", "."], "h": {"id": "C0085249", "name": "C0085249#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [10, 11]}}
{"token": ["Coronary", "artery", "cerebrovascular", "and", "C0085096#ent", "<e1>", "are", "the", "principal", "causes", "of", "morbidity", "and", "mortality", "in", "C0011854#ent", "<e2>"], "h": {"id": "C0085096", "name": "C0085096#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [15, 16]}}
{"token": ["Prior", "administration", "of", "PX", "has", "potentiated", "the", "C0020616#ent", "<e1>", "effect", "of", "C1427674#ent", "<e2>", "in", "rats", ",", "healthy", "human", "volunteers", "and", "diabetics", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1427674", "name": "C1427674#ent", "pos": [11, 12]}}
{"token": ["Differences", "in", "Ki", "values", "suggest", "differences", "in", "biochemical", "properties", "between", "the", "C0027203#ent", "<e1>", "from", "small", "intestine", "that", "isolated", "from", "C0030895#ent", "<e2>", "or", "kidney", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030895", "name": "C0030895#ent", "pos": [19, 20]}}
{"token": ["No", "significant", "correlation", "was", "found", "between", "the", "various", "activities", "except", "between", "DG(1", ")", "and", "DT(1", ")", "C1706403#ent", "<e1>", "activities", "and", "C0048681#ent", "<e2>", "and", "AZT", "C1706403#ent", "<e1>", "activities", "."], "h": {"id": "C0048681", "name": "C0048681#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1706403", "name": "C1706403#ent", "pos": [16, 17]}}
{"token": ["Gum", "arabic", "reduced", "the", "adsorption", "to", "alpha-cellulose", "of", "C1822725#ent", "<e1>", "and", "DNP", ",", "but", "not", "the", "adsorption", "of", "C0077413#ent", "<e2>", "or", "MeIQx", "."], "h": {"id": "C1822725", "name": "C1822725#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0077413", "name": "C0077413#ent", "pos": [18, 19]}}
{"token": ["We", "show", "that", "C1332005#ent", "<e1>", "is", "a", "substrate", "for", "the", "C1439337#ent", "<e2>"], "h": {"id": "C1332005", "name": "C1332005#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1439337", "name": "C1439337#ent", "pos": [10, 11]}}
{"token": ["Our", "C3540471#ent", "<e1>", "was", "to", "determine", "the", "reduced", "function", "of", "C0907532#ent", "<e2>", "preeclampsia", "by", "use", "of", "noninvasive", "techniques", "in", "vivo"], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0907532", "name": "C0907532#ent", "pos": [10, 11]}}
{"token": ["SGT1b", "was", "identified", "recently", "as", "a", "factor", "involved", "in", "plant", "disease", "resistance", "signaling", ",", "and", "C1424675#ent", "<e1>", "from", "barley", "and", "tobacco", "extracts", "shown", "to", "interact", "with", "SCF", "C0077678#ent", "<e2>"], "h": {"id": "C1424675", "name": "C1424675#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [27, 28]}}
{"token": ["C1424675#ent", "<e1>", "has", "been", "found", "to", "associate", "with", "SCF", "C0077678#ent", "<e2>", "the", "CBF3", "kinetochore", "complex", "plant", "R", "proteins", "related", "animal", "Nod-like", "receptors", "and", "with", "the", "Hsp90", "molecular", "chaperone"], "h": {"id": "C1424675", "name": "C1424675#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", "to", "chronic", "renal", "failure", "C1705340#ent", "<e1>", "was", "not", "significantly", "correlated", "with", "either", "plasma", "testosterone", "or", "C1418938#ent", "<e2>", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [17, 18]}}
{"token": ["Fractions", "were", "assayed", "for", "C1705340#ent", "<e1>", "and", "prolactin", "(", "C1418938#ent", "<e2>", ")", "by", "immunoradiometric", "assays", "IRMA", ")", "and", "for", "immunoglobulin", "G", "IgG", ")", "by", "radial", "immunodiffusion"], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [9, 10]}}
{"token": ["C0242350#ent", "<e1>", "assessed", "by", "fractional", "shortening", "C1414830#ent", "<e2>", ")", "was", "observed", "3", "hours", "after", "the", "onset", "of", "reperfusion", "following", "15", "minutes", "of", "complete", "occlusion", "of", "the", "left", "anterior", "descending", "coronary", "artery"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414830", "name": "C1414830#ent", "pos": [6, 7]}}
{"token": ["Both", "MGDF", "and", "IL-3", "induce", "tyrosine", "phosphorylation", "C1367307#ent", "<e1>", "(", "APRF", ")", "and", "STAT5", "(", "C1366480#ent", "<e2>", ")", ",", "with", "MGDF", "favoring", "C1367307#ent", "<e1>", "while", "IL-3", "predominantly", "causes", "STAT5", "phosphorylation", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366480", "name": "C1366480#ent", "pos": [15, 16]}}
{"token": ["C0251211#ent", "<e1>", "EC", "4.1.1.49", ";", "PEPCK", ",", "C2744579#ent", "<e2>", ")", "was", "purified", "from", "glycosomes", "of", "cultured", "procyclic", "Trypanosoma", "brucei", "electrophoretic", "homogeneity", "."], "h": {"id": "C0251211", "name": "C0251211#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [7, 8]}}
{"token": ["It", "is", "generally", "agreed", "that", "C1704665#ent", "<e1>", "plays", "a", "key", "role", "in", "C2712370#ent", "<e2>", "regulatory", "factors", "cellular", "proliferation", "the", "disease", "process"], "h": {"id": "C1704665", "name": "C1704665#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [12, 13]}}
{"token": ["We", "here", "examined", "the", "effects", "of", "C4019081#ent", "<e1>", "locally", "infused", "into", "the", "C3714941#ent", "<e2>", ",", "on", "instrumental", "behavior", "a", "progressive", "schedule", "of", "reinforcement", "."], "h": {"id": "C4019081", "name": "C4019081#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3714941", "name": "C3714941#ent", "pos": [12, 13]}}
{"token": ["EB1089-induced", "apoptosis", "was", "preceded", "by", "activation", "of", "C1456378#ent", "<e1>", "MAP", ")", "kinase", "and", "suppression", "of", "extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e2>", ")", "activity", ",", "and", "this", "was", "associated", "with", "downstream", "activation", "of", "caspase-3", "."], "h": {"id": "C1456378", "name": "C1456378#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [18, 19]}}
{"token": ["Little", "or", "no", "reactivity", "with", "glycolipids", "was", "detected", "for", "two", "patients", "with", "C0442874#ent", "<e1>", "and", "C1262215#ent", "<e2>", "for", "two", "with", "C0442874#ent", "<e1>", "and", "IgA", "gammopathy"], "h": {"id": "C1262215", "name": "C1262215#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [12, 13]}}
{"token": ["LPA-induced", "C0812234#ent", "<e1>", "activation", "is", "completely", "inhibited", "by", "tyrosine", "kinase", "inhibitors", "C0213654#ent", "<e2>", "47", "and", "genistein", ")", "."], "h": {"id": "C0812234", "name": "C0812234#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0213654", "name": "C0213654#ent", "pos": [11, 12]}}
{"token": ["RGS5", "is", "a", "member", "of", "regulators", "of", "G", "protein", "signaling", "RGS", ")", "C0086376#ent", "<e1>", "that", "attenuate", "C0752348#ent", "<e2>", "functioning", "as", "GTPase-activating", "proteins", "GAPs", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [16, 17]}}
{"token": ["C0086376#ent", "<e1>", "G", ")", "proteins", "are", "C0752348#ent", "<e2>", "that", "couple", "a", "wide", "range", "of", "receptors", "to", "ionic", "channels"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0752348", "name": "C0752348#ent", "pos": [6, 7]}}
{"token": ["Notably", ",", "the", "expression", "of", "smooth", "muscle", "actin", "C1704823#ent", "<e1>", "and", "Cd34", "together", "with", "C1704952#ent", "<e2>", ",", "Flk1", ",", "VE-cadherin", ",", "and", "Cd31", "suggested", "a", "phenotypic", "resemblance", "to", "pericytes", "and", "aorta-derived", "mesoangioblasts", "."], "h": {"id": "C1704823", "name": "C1704823#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704952", "name": "C1704952#ent", "pos": [14, 15]}}
{"token": ["A", "mitochondrial", "C1412058#ent", "<e1>", "ABC", ")", "protein", ",", "C1412073#ent", "<e2>", ",", "plays", "a", "role", "in", "iron", "homeostasis", "mitochondria", ",", "and", "defects", "in", "human", "C1412073#ent", "<e2>", "were", "shown", "to", "be", "responsible", "for", "the", "inherited", "disease", "X-linked", "sideroblastic", "anemia/ataxia"], "h": {"id": "C1412058", "name": "C1412058#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412073", "name": "C1412073#ent", "pos": [8, 9]}}
{"token": ["BACE", "is", "an", "C2717969#ent", "<e1>", "cleaves", "the", "amyloid", "precursor", "protein", "APP", ")", "at", "the", "C3811065#ent", "<e2>", "is", "involved", "in", "Alzheimer's", "disease"], "h": {"id": "C2717969", "name": "C2717969#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3811065", "name": "C3811065#ent", "pos": [14, 15]}}
{"token": ["The", "first", "and", "only", "functional", "Pbx1", "binding", "site", "been", "localized", "in", "bovine", "CYP17", "to", "a", "sequence", "(", "CRS1", ")", "that", "participates", "in", "C1412615#ent", "<e1>", "this", "gene", "encoding", "the", "steroid", "hydroxylase", "17", "C0038302#ent", "<e2>"], "h": {"id": "C1412615", "name": "C1412615#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038302", "name": "C0038302#ent", "pos": [31, 32]}}
{"token": ["Multiple", "initiation", "sites", "also", "found", "in", "a", "GC-rich", "region", "with", "Sp1", "binding", "motifs", "in", "exon", "I.", "Most", "t(14;18", ")", "C0072449#ent", "<e1>", "the", "3", "'", "UT", "of", "C1704467#ent", "<e2>", "implicating", "that", "event", "in", "gene", "deregulation"], "h": {"id": "C0072449", "name": "C0072449#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [26, 27]}}
{"token": ["In", "vitro", "nanomolar", "concentrations", "of", "C1710292#ent", "<e1>", "are", "required", "to", "alter", "C0669365#ent", "<e2>", "and", "vascular", "smooth", "muscle", "cell", "adhesion", "proliferation", ",", "motility", ",", "and", "survival", "."], "h": {"id": "C1710292", "name": "C1710292#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["Rab3B", ",", "Rab3C", ",", "Rab4", ",", "and", "C1417108#ent", "<e1>", "were", "detected", ",", "but", "C1419206#ent", "<e2>", "was", "not", "."], "h": {"id": "C1417108", "name": "C1417108#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419206", "name": "C1419206#ent", "pos": [13, 14]}}
{"token": ["Sputum", "cultures", "all", "the", "patients", "grew", "P.", "aeruginosa", "except", "for", "one", "patient", "with", "C0033817#ent", "<e1>", "the", "minimal", "inhibitory", "concentration", "of", "C0008809#ent", "<e2>", "for", "these", "organisms", "ranged", "from", "0.05", "to", "1.56", "micrograms/ml", "."], "h": {"id": "C0033817", "name": "C0033817#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [20, 21]}}
{"token": ["We", "report", "that", "C0037511#ent", "<e1>", "produces", "a", "dose-related", "decrease", "in", "hypoglycemic", "C0036572#ent", "<e2>", "and", "glucoprivic", "feeding", ",", "suggesting", "that", "a", "loss", "in", "sensitivity", "to", "insulin", "may", "contribute", "to", "the", "MSG", "syndrome", "."], "h": {"id": "C0037511", "name": "C0037511#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [11, 12]}}
{"token": ["C0037511#ent", "<e1>", "completely", "prevented", "C0036572#ent", "<e2>", "."], "h": {"id": "C0037511", "name": "C0037511#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [4, 5]}}
{"token": ["The", "resuspended", "and", "dialysed", "precipitate", "chromatographed", "on", "DEAE-cellulose", "DE-32", "to", "allow", "separation", "of", "cathepsins", "H", "C", "from", "C0007428#ent", "<e1>", "L.", "The", "main", "isoform", "of", "cathepsin", "H", "separated", "from", "C1413811#ent", "<e2>", "cation-exchange", "chromatography", "CM-Sephadex", "C-50", "."], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413811", "name": "C1413811#ent", "pos": [28, 29]}}
{"token": ["Several", "good", "intracellular", "C1413811#ent", "<e1>", "VS", "inhibitors", "lacked", "reactivity", "with", "C0007428#ent", "<e2>", "H", "and", "L.", "In", "conclusion", ",", "we", "have", "identified", "C1413811#ent", "<e1>", "inhibitors", "suitable", "for", "cellular", "applications"], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413811", "name": "C1413811#ent", "pos": [3, 4]}}
{"token": ["Downstream", "of", "Src", ",", "the", "C1413554#ent", "<e1>", "also", "activated", "Rac1", "and", "JNK", ",", "which", "enhanced", "CBR1-mediated", "C1367307#ent", "<e2>", "activation", "."], "h": {"id": "C1413554", "name": "C1413554#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [16, 17]}}
{"token": ["The", "C1413554#ent", "<e1>", "agonist", "HU-210", "induced", "pertussis", "toxin-sensitive", "Src", "and", "C1367307#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C1413554", "name": "C1413554#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [10, 11]}}
{"token": ["GSL", "type", "II", "contained", "no", "Gtet", "C0017083#ent", "<e1>", "and", "no", "C0007804#ent", "<e2>", "."], "h": {"id": "C0017083", "name": "C0017083#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [10, 11]}}
{"token": ["Overall", ",", "data", "suggest", "that", "induction", "of", "C1706544#ent", "<e1>", "expression", "by", "gammaIR", "is", "associated", "with", "C0007367#ent", "<e2>", "."], "h": {"id": "C1706544", "name": "C1706544#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [15, 16]}}
{"token": ["Breakpoints", "cluster", "limited", "regions", "of", "RARA", "and", "C1366903#ent", "<e1>", ",", "and", "PML/RARA", "and", "C3888082#ent", "<e2>", "transcripts", "can", "also", "be", "detected", "by", "RT-PCR", "."], "h": {"id": "C1366903", "name": "C1366903#ent", "pos": [7, 8]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3888082", "name": "C3888082#ent", "pos": [13, 14]}}
{"token": ["Because", "C1366512#ent", "<e1>", "is", "a", "signaling", "protein", "of", "interacting", "with", "tyrosine", "kinase", "receptors", "we", "tested", "genetically", "whether", "C1366512#ent", "<e1>", "might", "act", "downstream", "of", "insulin-like", "growth", "factor", "2", "a", "paternally", "expressed", "C1335278#ent", "<e1>"], "h": {"id": "C1366512", "name": "C1366512#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335278", "name": "C1335278#ent", "pos": [30, 31]}}
{"token": ["Similarly", ",", "in", "early", "pregnancy", "i.e.", "first", "trimester", ")", "endometrium", ",", "C1420459#ent", "<e1>", "expression", "was", "absent", ",", "although", "SULT1A1", "and", "C1420516#ent", "<e2>", "expression", "were", "unaffected", "."], "h": {"id": "C1420459", "name": "C1420459#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420516", "name": "C1420516#ent", "pos": [20, 21]}}
{"token": ["Because", "guanosine", "3',5'-cyclic", "monophosphate", "cGMP", ")", "and", "C1259877#ent", "<e1>", "implicated", "in", "the", "second", "messenger", "cascades", "of", "ANF", "and", "C1705889#ent", "<e2>", ",", "we", "investigated", "their", "potential", "roles", "in", "mediating", "this", "interaction", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705889", "name": "C1705889#ent", "pos": [18, 19]}}
{"token": ["As", "data", "from", "the", "C0026289#ent", "<e1>", "Amiodarone", "Atrial", "Fibrillation", "Efficacy", "Trial", "demonstrate", ",", "conventional", "C0003195#ent", "<e2>", "have", "a", "role", "in", "highly", "symptomatic", "AF", "accompanied", "by", "decreased", "quality", "of", "life"], "h": {"id": "C0026289", "name": "C0026289#ent", "pos": [4, 5]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [14, 15]}}
{"token": ["C0043832#ent", "<e1>", "is", "protective", "in", "experimental", "colitis", "C0017152#ent", "<e2>", ",", "probably", "due", "to", "decreased", "production", "of", "iron-dependent", "oxygen-free", "radicals"], "h": {"id": "C0043832", "name": "C0043832#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [7, 8]}}
{"token": ["C0265308#ent", "<e1>", "is", "reduced", "by", "NADH-reduced", "diaphorase", "(", "or", "related", "C3540790#ent", "<e2>", ")", "and", "the", "reduced", "C0265308#ent", "<e1>", "is", "reoxidized", "by", "autoxidation", "and", "a", "peroxidase-catalyzed", "reaction", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0265308", "name": "C0265308#ent", "pos": [0, 1]}}
{"token": ["We", "postulate", "that", "deep", "brain", "stimulation", "the", "substantia", "nigra", "pars", "compacta", "ameliorate", "hyperkinesia", "in", "C0008489#ent", "<e1>", "thus", "representing", "the", "first", "effective", "therapy", "in", "C0020179#ent", "<e2>"], "h": {"id": "C0008489", "name": "C0008489#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0020179", "name": "C0020179#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "Ndr", "and", "its", "close", "relatives", "may", "operate", "in", "a", "novel", "signaling", "pathway", "downstream", "of", "an", "as-yet-unidentified", "C0031727#ent", "<e1>", "with", "specificity", "similar", "to", ",", "but", "distinct", "from", ",", "C2000212#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [18, 19]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2000212", "name": "C2000212#ent", "pos": [29, 30]}}
{"token": ["Characterization", "of", "the", "metabolic", "defect", "TRMA", "may", "shed", "light", "on", "the", "role", "of", "C0005122#ent", "<e1>", "such", "common", "C0029896#ent", "<e2>", "."], "h": {"id": "C0005122", "name": "C0005122#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}}
{"token": ["Age", ",", "autopsy", "delay", "time", "in", "storage", ",", "liver", "diseases", "C0005122#ent", "<e1>", "CNS", "medications", ",", "and", "various", "C0029896#ent", "<e2>", "causing", "acute", "and", "chronic", "hypoxia", "not", "significantly", "affect", "receptor", "density", "affinity", "."], "h": {"id": "C0005122", "name": "C0005122#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "anti-", "beta(2)-GPI", "antibodies", "and", "C2697656#ent", "<e1>", "followed", "the", "same", "time", "kinetic", "of", "IL-1", "receptor-activated", "kinase", "C1334134#ent", "<e2>", ")", "phosphorylation", ",", "suggesting", "an", "involvement", "of", "the", "toll-like", "receptor", "TLR", ")", "family", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334134", "name": "C1334134#ent", "pos": [17, 18]}}
{"token": ["C0529793#ent", "<e1>", "marketed", "under", "the", "trademark", "name", "C0663448#ent", "<e2>", "and", "is", "widely", "used", "to", "treat", "male", "erectile", "dysfunction", "therapeutic", "uses", "of", "this", "medication", "for", "other", "diseases", "related", "to", "vascular", "dysfunction", "emerging", "."], "h": {"id": "C0529793", "name": "C0529793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0663448", "name": "C0663448#ent", "pos": [7, 8]}}
{"token": ["The", "effects", "of", "androgen", "on", "the", "activities", "of", "C0030940#ent", "<e1>", "and", "delta", "4", "-", "C1420395#ent", "<e2>", "investigated", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420395", "name": "C1420395#ent", "pos": [14, 15]}}
{"token": ["It", "was", "found", "that", "hemosorption", "results", "in", "lowering", "of", "all", "the", "above", "concentrations", "in", "nonspecific", "C0009324#ent", "<e1>", "except", "seromucoid", "and", "orosomucoid", "in", "moderate", "and", "C2118460#ent", "<e2>"], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2118460", "name": "C2118460#ent", "pos": [24, 25]}}
{"token": ["Treatment", "with", "bromocriptine", ",", "C0002403#ent", "<e1>", "and", "L-dops", "had", "no", "effect", "but", "the", "C0030567#ent", "<e2>", "dramatically", "improved", "with", "administration", "of", "L-dopa", "."], "h": {"id": "C0002403", "name": "C0002403#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [13, 14]}}
{"token": ["C0008196#ent", "<e1>", ",", "the", "most", "used", "biocide", "in", "periodontology", ",", "C2712370#ent", "<e2>", "the", "permeability", "of", "the", "bacterial", "cell", "membrane"], "h": {"id": "C0008196", "name": "C0008196#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [10, 11]}}
{"token": ["Since", "this", "molecule", "showed", "enzymatic", "activity", "produce", "C0003873#ent", "<e1>", "from", "retinaldehyde", ",", "we", "designated", "it", "C1412340#ent", "<e2>", "RALDH-3", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412340", "name": "C1412340#ent", "pos": [15, 16]}}
{"token": ["Phylogenetic", "analysis", "that", "the", "novel", "C0020209#ent", "<e1>", "forms", "a", "new", "branch", "separate", "from", "other", "C0020208#ent", "<e2>", "like", "dihydropyrimidinases", "(", "EC", "3.5.2.2", ")", "and", "allantoinases", "(", "EC", "3.5.2.5", ")", "."], "h": {"id": "C0020209", "name": "C0020209#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020208", "name": "C0020208#ent", "pos": [14, 15]}}
{"token": ["Using", "two", "routes", "starting", "from", "cyclanones", ",", "it", "has", "been", "possible", "to", "prepare", "two", "series", "of", "C0020209#ent", "<e1>", "substituted", "or", "not", "on", "the", "C0020208#ent", "<e2>", "nitrogen", "."], "h": {"id": "C0020209", "name": "C0020209#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020208", "name": "C0020208#ent", "pos": [23, 24]}}
{"token": ["Point", "mutations", "deletions", "in", "the", "androgen", "receptor", "gene", "C0268301#ent", "<e1>", "however", "subjects", "with", "Kennedy's", "disease", "normal", "virilization", "although", "progressive", "C0018418#ent", "<e2>", ",", "testicular", "atrophy", "infertility", "may", "occur", "."], "h": {"id": "C0268301", "name": "C0268301#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0018418", "name": "C0018418#ent", "pos": [19, 20]}}
{"token": ["In", "BALF", "cytospins", ",", "both", "C0172956#ent", "<e1>", "mRNA", "expression", "were", "observed", "in", "epithelial", "cells", "macrophages", ",", "and", "C0064833#ent", "<e2>", "PMNs", ")", "."], "h": {"id": "C0172956", "name": "C0172956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [17, 18]}}
{"token": ["C1418251#ent", "<e1>", "increased", "gene", "expression", ",", "but", "the", "presence", "of", "C0011777#ent", "<e2>", "only", "induced", "PAH-dependent", "expression", "by", "1.5-fold", ",", "suggesting", "interaction", "between", "GR", "and", "the", "aryl", "hydrocarbon", "Ah", ")", "receptor", "."], "h": {"id": "C1418251", "name": "C1418251#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}}
{"token": ["The", "maximum", "protection", "against", "upper", "tract", "lesions", "(", "C0035455#ent", "<e1>", ",", "otitis", ",", "and", "C0023076#ent", "<e2>", ")", "was", "provided", "by", "intravenous", "immunization", "viable", "organisms", "."], "h": {"id": "C0035455", "name": "C0035455#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023076", "name": "C0023076#ent", "pos": [14, 15]}}
{"token": ["Conventional", "C3273153#ent", "<e1>", "of", "unbound", "drugs", "and", "C0013227#ent", "<e2>", "which", "are", "loosely", "bound", "to", "plasma", "proteins", "as", "albumin", "and", "alpha-1", "acid", "glycoprotein", "forming", "an", "equilibrium", "ratio", "bound", "and", "unbound", "drugs", "."], "h": {"id": "C3273153", "name": "C3273153#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [7, 8]}}
{"token": ["C1335191#ent", "<e1>", "response-4", "(", "Par-4", ")", "is", "a", "C2829281#ent", "<e2>", "characterized", "as", "a", "critical", "regulator", "of", "apoptosis", "in", "prostate", "cancer", "cells", "."], "h": {"id": "C1335191", "name": "C1335191#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2829281", "name": "C2829281#ent", "pos": [8, 9]}}
{"token": ["Drosophila", "C3538733#ent", "<e1>", "(", "dmiR-1", ")", "is", "regulated", "through", "a", "serum", "response", "C1538441#ent", "<e2>", "cardiac", "progenitor", "cells"], "h": {"id": "C3538733", "name": "C3538733#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538441", "name": "C1538441#ent", "pos": [12, 13]}}
{"token": ["Proteinase", "A", "substantial", "homology", "to", "mammalian", "C0078989#ent", "<e1>", "such", "as", "C0030909#ent", "<e2>", ",", "renin", ",", "and", "cathepsin", "D."], "h": {"id": "C0078989", "name": "C0078989#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030909", "name": "C0030909#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "podocyte-derived", "VEGF", "operates", "in", "an", "autocrine", "loop", "likely", "through", "VEGFR-1", "and", "C1705325#ent", "<e1>", "to", "stimulate", "alpha3(IV)", "C0009325#ent", "<e2>", "production", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [18, 19]}}
{"token": ["We", "hypothesized", "that", "ERK", "and", "C1705325#ent", "<e1>", "be", "involved", "in", "C0009325#ent", "<e2>", "and", "extracellular", "matrix", "production", "in", "KFs", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "C0006217#ent", "<e1>", "treatment", "attenuated", "DMBA-TPA-induced", "phosphorylation", "of", "C0082529#ent", "<e2>", "ERK1/2", ")", ",", "mitogen-activated", "protein", "kinase", "MAPK", ")", "and", "Akt", "."], "h": {"id": "C0006217", "name": "C0006217#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [10, 11]}}
{"token": ["All", "12", "C0026794#ent", "<e1>", "exhibited", "a", "constant", "ratio", "of", "C0030962#ent", "<e2>", "to", "glutathione", "oxidase", "activities", ",", "strongly", "supporting", "the", "conclusion", "that", "conversion", "of", "glutathione", "to", "glutathione", "disulfide", "a", "catalytic", "function", "gamma-glutamyl", "transpeptidase"], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030962", "name": "C0030962#ent", "pos": [9, 10]}}
{"token": ["Incubation", "of", "schistosomes", "with", "high", "concentrations", "of", "carbachol", "or", "with", "C0242893#ent", "<e1>", "to", "compete", "with", "the", "C0036336#ent", "<e2>", "effects", "of", "HC", "."], "h": {"id": "C0242893", "name": "C0242893#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036336", "name": "C0036336#ent", "pos": [16, 17]}}
{"token": ["the", "enantiomer", "of", "C0247133#ent", "<e1>", "with", "1000-fold", "lower", "affinity", "for", "the", "C1424685#ent", "<e2>", "was", "without", "effect", "."], "h": {"id": "C0247133", "name": "C0247133#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1424685", "name": "C1424685#ent", "pos": [11, 12]}}
{"token": ["potentiated", "the", "stereotyped", "sniffing", "behaviour", "induced", "by", "C0070559#ent", "<e1>", ",", "a", "specific", "substrate", "for", "C4084845#ent", "<e2>"], "h": {"id": "C0070559", "name": "C0070559#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4084845", "name": "C4084845#ent", "pos": [14, 15]}}
{"token": ["To", "localize", "the", "determinants", "of", "the", "narrow", "tropism", "of", "the", "v-abl", "gene", "we", "generated", "a", "series", "of", "hybrid", "C0035369#ent", "<e1>", "genomes", "containing", "portions", "of", "the", "v-abl", "and", "C3853558#ent", "<e2>", "a", "Moloney", "murine", "leukemia", "virus", "backbone"], "h": {"id": "C0035369", "name": "C0035369#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3853558", "name": "C3853558#ent", "pos": [27, 28]}}
{"token": ["Null", "mutations", "the", "genes", "encoding", "C3815270#ent", "<e1>", ",", "SipC", "or", "C3540529#ent", "<e2>", ",", "prevented", "protein", "translocation", "indicating", "that", "these", "proteins", "are", "involved", "in", "the", "translocation", "process"], "h": {"id": "C3815270", "name": "C3815270#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540529", "name": "C3540529#ent", "pos": [10, 11]}}
{"token": ["Fever", "during", "an", "episode", "of", "active", "urinary", "infection", "a", "strong", "indication", "that", "the", "patient", "has", "C0042580#ent", "<e1>", "some", "other", "significant", "C0042075#ent", "<e2>", "and", "probably", "pyelonephritis", "."], "h": {"id": "C0042580", "name": "C0042580#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [20, 21]}}
{"token": ["The", "C0005064#ent", "<e1>", "chlorodiazepoxide", ",", "diazepam", "and", "C0242293#ent", "<e2>", "and", "meprobamate", "depress", "the", "response", "of", "the", "guinea-pig", "ileum", "acetylcholine", ",", "histamine", "and", "5-hydroxytryptamine", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0242293", "name": "C0242293#ent", "pos": [7, 8]}}
{"token": ["In", "the", "present", "study", "we", "used", "cohorts", "of", "Munich-Wistar", "rats", "to", "assess", "effects", "of", "C0520680#ent", "<e1>", "on", "the", "threshold", "for", "C0494475#ent", "<e2>"], "h": {"id": "C0520680", "name": "C0520680#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0494475", "name": "C0494475#ent", "pos": [20, 21]}}
{"token": ["Equilibrium", "measurements", "over", "a", "large", "range", "of", "concentrations", "revealed", "a", "single", "homogeneous", "population", "of", "high-affinity", "binding", "sites", "(", "C0026691#ent", "<e1>", "=", "0.46", "nM", ";", "Bmax", "=", "92", "fmol/mg", "C1334693#ent", "<e2>", "."], "h": {"id": "C0026691", "name": "C0026691#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1334693", "name": "C1334693#ent", "pos": [28, 29]}}
{"token": ["Homologous", "restriction", "factor", "a", "molecular", "weight", "20", "C0026691#ent", "<e1>", "(", "HRF20", ")", "is", "a", "C1334693#ent", "<e2>", "inhibits", "assembly", "of", "the", "membrane", "attack", "complex", "homologous", "complement"], "h": {"id": "C0026691", "name": "C0026691#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334693", "name": "C1334693#ent", "pos": [14, 15]}}
{"token": ["A", "model", "of", "C0019151#ent", "<e1>", "be", "produced", "using", "methionine", "sulfoximine", "inhibit", "irreversibly", "the", "C0009227#ent", "<e2>", "resulting", "in", "elevated", "brain", "ammonia", "and", "development", "of", "Alzheimer", "type", "II", "astrocytosis"], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009227", "name": "C0009227#ent", "pos": [13, 14]}}
{"token": ["Duration", "of", "current", "or", "past", "use", "of", "postmenopausal", "hormones", "and", "dose", "of", "conjugated", "C2936882#ent", "<e1>", "were", "not", "significantly", "related", "to", "incidence", "of", "C0011860#ent", "<e2>", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [22, 23]}}
{"token": ["C0772162#ent", "<e1>", "than", "catechols", "did", "not", "markedly", "influence", "C1420718#ent", "<e2>", "activity", "."], "h": {"id": "C0772162", "name": "C0772162#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [8, 9]}}
{"token": ["Caerulein-stimulated", "release", "of", "Ca2", "+", "was", "completely", "blocked", "by", "either", "neomycin", ",", "an", "inhibitor", "of", "C0031671#ent", "<e1>", "or", "by", "heparin", ",", "an", "C0019593#ent", "<e2>"], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [22, 23]}}
{"token": ["Our", "results", "indicate", "that", "the", "cardiac", "isoform", "C1413134#ent", "<e1>", "is", "the", "preferred", "substrate", "for", "C0108555#ent", "<e2>", "in", "vivo", "in", "vitro"], "h": {"id": "C1413134", "name": "C1413134#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0108555", "name": "C0108555#ent", "pos": [14, 15]}}
{"token": ["C0051131#ent", "<e1>", "was", "adsorbed", "to", "neither", "dextran", "nor", "raw", "potato", "C0054259#ent", "<e2>", "."], "h": {"id": "C0051131", "name": "C0051131#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [10, 11]}}
{"token": ["C1824754#ent", "<e1>", "is", "a", "C1334043#ent", "<e2>", "mitochondria", "of", "Saccharomyces", "cerevisiae"], "h": {"id": "C1824754", "name": "C1824754#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [4, 5]}}
{"token": ["Staining", "dorsal", "root", "ganglion", "sections", "with", "an", "C0008407#ent", "<e1>", "cross-reactive", "material", "localized", "in", "axons", "in", "the", "C0085648#ent", "<e2>", ";", "no", "evidence", "suggests", "the", "presence", "of", "cholinergic", "synaptic", "structures", "AChR", "clusters", "on", "neuronal", "somata", "the", "C0085648#ent", "<e2>", "."], "h": {"id": "C0008407", "name": "C0008407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [16, 17]}}
{"token": ["C0024117#ent", "<e1>", "is", "specific", "to", "C1414438#ent", "<e2>", "and", "has", "no", "cross", "reaction", "myeloperoxidase", "."], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [5, 6]}}
{"token": ["Northern", "blot", "analysis", "the", "expression", "of", "the", "VDR", "gene", "the", "C1706113#ent", "<e1>", "mRNA", "bands", "prominent", "in", "1,25(OH)2D3", ",", "serum", "or", "C0917964#ent", "<e2>", "treated", "fibroblasts", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [20, 21]}}
{"token": ["Twenty", "patients", "were", "suffering", "from", "spondylarthropathy", "(", "SPA", ")", ",", "18", "from", "C0038013#ent", "<e1>", "AS", ")", ",", "24", "from", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", ",", "and", "15", "from", "mixed", "connective", "tissue", "disease", "MCTD", ")", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}}
{"token": ["We", "describe", "a", "patient", "with", "lupus", "nephritis", "C0007785#ent", "<e1>", "who", "subsequently", "developed", "recurrent", "C0270739#ent", "<e2>", "associated", "with", "increased", "aPLs", "levels", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0270739", "name": "C0270739#ent", "pos": [13, 14]}}
{"token": ["Post-operative", "vomiting", "C0270697#ent", "<e1>", ",", "sore", "throat", "confusion", "occurred", "with", "similar", "frequency", ",", "and", "C0728960#ent", "<e2>", "and", "antiemetic", "requirements", "were", "not", "influenced", "by", "the", "technique", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [14, 15]}}
{"token": ["Such", "coevolution", "at", "the", "amino", "acid-sequence", "is", "well", "documented", "and", "has", "been", "used", "to", "predict", "C1423524#ent", "<e1>", "domains", ",", "and", "C3539947#ent", "<e2>"], "h": {"id": "C1423524", "name": "C1423524#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [20, 21]}}
{"token": ["MDA", ",", "GSH", ",", "and", "C1417771#ent", "<e1>", "levels", "were", "analyzed", "spectrophotometrically", "in", "C0597563#ent", "<e2>", "basal", "forebrain"], "h": {"id": "C1417771", "name": "C1417771#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597563", "name": "C0597563#ent", "pos": [12, 13]}}
{"token": ["C0034417#ent", "<e1>", "are", "known", "to", "mankind", "and", "have", "been", "in", "medical", "use", "C0024530#ent", "<e2>", "for", "over", "350", "years", "."], "h": {"id": "C0034417", "name": "C0034417#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [12, 13]}}
{"token": ["C0019693#ent", "<e1>", "RT", "is", "an", "C0035681#ent", "<e2>", "whereas", "HPV", "E1", "is", "a", "DNA", "helicase"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [5, 6]}}
{"token": ["These", "data", "suggest", "that", "even", "if", "excessive", "corneal", "power", "eliminated", "after", "penetrating", "keratoplasty", "C1835677#ent", "<e1>", "the", "associated", "C1443296#ent", "<e2>", "still", "produce", "a", "mean", "spherical", "refractive", "error", "of", "at", "least", "-2.8", "dioptres", "."], "h": {"id": "C1835677", "name": "C1835677#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1443296", "name": "C1443296#ent", "pos": [17, 18]}}
{"token": ["Plasminogen", "activator", "inhibitor", "1", "C1705527#ent", "<e1>", ")", "is", "a", "C0072522#ent", "<e2>", "that", "controls", "the", "activity", "of", "the", "key", "enzymes", "of", "the", "fibrinolytic", "system", "the", "serine", "proteases", "tissue-type", "plasminogen", "activator", "t-PA", ")", "and", "urokinase-type", "plasminogen", "activator", "u-PA", ")", "."], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [9, 10]}}
{"token": ["The", "glycoprotein", "VI", "(GPVI)-Fc", "receptor", "(", "FcR", ")", "gamma-chain", "complex", "a", "key", "activatory", "receptor", "collagen", "on", "platelet", "surface", "membranes", ",", "is", "constitutively", "associated", "with", "C0038085#ent", "<e1>", "Fyn", "and", "C1442804#ent", "<e2>", "."], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [24, 25]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [28, 29]}}
{"token": ["The", "structural", "gene", "for", "the", "synthesis", "of", "cytochrome", "c(L", ",", "an", "electron", "acceptor", "required", "for", "C3489580#ent", "<e1>", "and", "the", "genes", "encoding", "small", "basic", "C0030956#ent", "<e2>", "that", "copurified", "with", "methanol", "dehydrogenases", "closely", "linked", "to", "the", "C3489580#ent", "<e1>", "structural", "genes"], "h": {"id": "C3489580", "name": "C3489580#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [23, 24]}}
{"token": ["This", "method", "was", "applied", "to", "study", "the", "pharmacokinetic", "profiles", "doxorubicin", "and", "C0050885#ent", "<e1>", "in", "rats", "after", "a", "single", "dose", "administration", "of", "C1522690#ent", "<e2>", "HCl", "."], "h": {"id": "C0050885", "name": "C0050885#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1522690", "name": "C1522690#ent", "pos": [21, 22]}}
{"token": ["In", "the", "present", "study", ",", "we", "tested", "whether", "C1516035#ent", "<e1>", "encapsulated", "in", "liposomes", "kills", "C0919442#ent", "<e2>", "the", "efficacy", "superior", "to", "that", "of", "unencapsulated", "C1516035#ent", "<e1>", "."], "h": {"id": "C0919442", "name": "C0919442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1516035", "name": "C1516035#ent", "pos": [8, 9]}}
{"token": ["These", "results", "strongly", "suggest", "that", "C1420196#ent", "<e1>", "is", "the", "target", "molecule", "of", "C1412292#ent", "<e2>", "and", "that", "C1412292#ent", "<e2>", "has", "an", "important", "role", "in", "pH", "regulation", "C1420196#ent", "<e1>", "."], "h": {"id": "C1420196", "name": "C1420196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412292", "name": "C1412292#ent", "pos": [12, 13]}}
{"token": ["The", "clinical", "features", "were", "characterized", "by", "C0206085#ent", "<e1>", ",", "memory", "disturbance", "disorientation", "to", "time", "and", "C0018991#ent", "<e2>", "the", "face", "."], "h": {"id": "C0206085", "name": "C0206085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018991", "name": "C0018991#ent", "pos": [15, 16]}}
{"token": ["C1418825#ent", "<e1>", "induction", "by", "BDNF", "in", "vitro", "C0044602#ent", "<e2>", "PI3K", ",", "but", "inhibition", "of", "phosphorylation", "of", "protein", "kinase", "B/Akt", "does", "not", "entirely", "abolish", "expression", "of", "C1418825#ent", "<e1>", "."], "h": {"id": "C1418825", "name": "C1418825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [7, 8]}}
{"token": ["No", "studies", "of", "concentrations", "of", "ascorbic", "acid", "C3539946#ent", "<e1>", "the", "aqueous", "humor", "of", "the", "C1848862#ent", "<e2>", "have", "been", "performed", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [14, 15]}}
{"token": ["The", "method", "was", "employed", "to", "test", "four", "different", "tablet", "formulations", "consisting", "of", "the", "model", "drug", "NaCl", "in", "excipient", "matrices", "hard", "fat", "C0032483#ent", "<e1>", "microcrystalline", "cellulose", "a", "mixture", "of", "microcrystalline", "cellulose", "C0037487#ent", "<e2>", "Ac-Di-Sol", ")", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0037487", "name": "C0037487#ent", "pos": [30, 31]}}
{"token": ["C0003123#ent", "<e1>", "patients", "displayed", "a", "low", "REE", "and", "C1418224#ent", "<e2>", "."], "h": {"id": "C0003123", "name": "C0003123#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418224", "name": "C1418224#ent", "pos": [8, 9]}}
{"token": ["Advanced", "treatment", "methods", "ozonation", "and", "C0001275#ent", "<e1>", "GAC", ")", "adsorption", "were", "tested", "to", "remove", "C1720911#ent", "<e2>", "from", "drinking", "water"], "h": {"id": "C0001275", "name": "C0001275#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1720911", "name": "C1720911#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "C1824882#ent", "<e1>", "appears", "to", "be", "extensively", "metabolized", "by", "adult", "FMO-mediated", "C0020364#ent", "<e2>", "."], "h": {"id": "C1824882", "name": "C1824882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020364", "name": "C0020364#ent", "pos": [14, 15]}}
{"token": ["HP", "caused", "by", "C0004623#ent", "<e1>", "thus", "likely", "and", "antibiotics", ",", "rifampicin", "and", "C0025872#ent", "<e2>", ",", "were", "administered", "orally", "as", "an", "outpatient", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [12, 13]}}
{"token": ["Therapy", "of", "C0005716#ent", "<e1>", "has", "been", "broadened", "with", "the", "addition", "of", "C0022625#ent", "<e2>", "."], "h": {"id": "C0005716", "name": "C0005716#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [11, 12]}}
{"token": ["Once", "C0005716#ent", "<e1>", "is", "diagnosed", ",", "therapeutic", "options", "include", "treatment", "with", "amphotericin", "B", "C0022625#ent", "<e2>", ",", "or", "simple", "observation", "if", "spontaneous", "resolution", "is", "anticipated", "."], "h": {"id": "C0005716", "name": "C0005716#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [13, 14]}}
{"token": ["These", "results", "support", "further", "investigation", "of", "NPY", ",", "LEP", ",", "and", "C1366515#ent", "<e1>", "to", "identify", "genetic", "variation", "may", "influence", "C0028754#ent", "<e2>", "glucose", "and", "lipid", "metabolism", "and", "blood", "pressure", "Mexican", "Americans"], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [11, 12]}, "relation": "gene_associated_with_disease", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [19, 20]}}
{"token": ["Protein", "expression", "the", "organic", "cation", "transporters", "C1706343#ent", "<e1>", "and", "rOCT2", "progressively", "decreased", "with", "increasing", "C0720099#ent", "<e2>", "of", "diabetes", "."], "h": {"id": "C1706343", "name": "C1706343#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [14, 15]}}
{"token": ["Inhibition", "of", "C1417857#ent", "<e1>", "binding", "with", "a", "C0030956#ent", "<e2>", "derived", "from", "GBR2", "(", "TAT-Pep-27", ")", "did", "not", "affect", "basal", "signaling", "but", "almost", "completely", "abolished", "agonist-promoted", "GBR", "desensitization", "in", "both", "CHO", "cells", "hippocampal", "slices", "."], "h": {"id": "C1417857", "name": "C1417857#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}}
{"token": ["A", "major", "quantitative", "trait", "locus", "C3826857#ent", "<e1>", ")", "controlling", "response", "to", "photoperiod", ",", "C4050150#ent", "<e2>", ",", "was", "identified", "by", "means", "of", "a", "map-based", "cloning", "strategy", "."], "h": {"id": "C3826857", "name": "C3826857#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4050150", "name": "C4050150#ent", "pos": [13, 14]}}
{"token": ["The", "C0014442#ent", "<e1>", "resembles", "another", "C0283436#ent", "<e2>", "isolated", "from", "the", "cytosol", "fraction", "of", "intestinal", "mucosa"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0283436", "name": "C0283436#ent", "pos": [5, 6]}}
{"token": ["C0017920#ent", "<e1>", "is", "associated", "with", "severe", "C0020473#ent", "<e2>", "and", "hepatic", "steatosis"], "h": {"id": "C0017920", "name": "C0017920#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [6, 7]}}
{"token": ["The", "half-lives", "of", "C0074681#ent", "<e1>", "were", "similar", "to", "plasmin", "or", "C0032483#ent", "<e2>", "treated", "and", "sulfonated", "human", "."], "h": {"id": "C0074681", "name": "C0074681#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [10, 11]}}
{"token": ["Four", "C1412821#ent", "<e1>", "the", "same", "relative", "orientation", "as", "the", "C4284736#ent", "<e2>", "element-encoded", "xisA", "gene", "were", "identified", "in", "the", "sequenced", "region"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4284736", "name": "C4284736#ent", "pos": [9, 10]}}
{"token": ["The", "parameters", "of", "electrolyte", "profile", "and", "some", "neurohumoral", "regulatory", "systems", "were", "compared", "in", "257", "patients", "with", "C0403447#ent", "<e1>", "CCI", ")", "secondary", "to", "coronary", "heart", "disease", "the", "presence", "or", "absence", "of", "C0085580#ent", "<e2>"], "h": {"id": "C0403447", "name": "C0403447#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [30, 31]}}
{"token": ["Furthermore", ",", "in", "accordance", "with", "their", "effects", "on", "neuronal", "survival", "C3540800#ent", "<e1>", "prevented", "the", "induction", "of", "C1623430#ent", "<e2>", "trophic", "factor-deprived", "CGNs", ",", "whereas", "VPA", "potentiated", "it", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [16, 17]}}
{"token": ["Picolinic", "acid", "a", "catabolite", "of", "C0041260#ent", "<e1>", ",", "activates", "the", "transcription", "of", "the", "C1533698#ent", "<e2>", "iNOS", ")", "in", "IFN-gamma-treated", "murine", "macrophages", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [13, 14]}}
{"token": ["In", "a", "controlled", ",", "randomized", ",", "double-blind", "trial", "the", "value", "of", "C0008783#ent", "<e1>", "as", "prophylaxis", "against", "C0032290#ent", "<e2>", "studied", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032290", "name": "C0032290#ent", "pos": [16, 17]}}
{"token": ["Fourteen", "C0011854#ent", "<e1>", "symptoms", "and", "signs", "of", "delayed", "gastric", "emptying", "treated", "with", "new", "C1268865#ent", "<e2>", "cisapride", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1268865", "name": "C1268865#ent", "pos": [13, 14]}}
{"token": ["Forty", "percent", "of", "the", "patients", "had", "C0020255#ent", "<e1>", "meningomyelocele", ",", "33", "%", "congenital", "communicating", "or", "C0549423#ent", "<e2>", "and", "18", "%", "tumors", "."], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0549423", "name": "C0549423#ent", "pos": [15, 16]}}
{"token": ["C0020255#ent", "<e1>", "of", "two", "subtypes", ",", "communicating", "hydrocephalus", "and", "C0549423#ent", "<e2>"], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0549423", "name": "C0549423#ent", "pos": [9, 10]}}
{"token": ["Several", "factors", "which", "may", "explain", "the", "increase", "in", "the", "total", "CSF", "protein", "C0020255#ent", "<e1>", "described", ":", "low", "age", "ventricular", "block", "the", "C0549423#ent", "<e2>", "and", "probable", "passage", "of", "tissue", "proteins", "the", "CSF", "from", "the", "damaged", "brain", "."], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0549423", "name": "C0549423#ent", "pos": [21, 22]}}
{"token": ["Tg", "epitope", "inactivation", "induced", "by", "C0885449#ent", "<e1>", "depended", "on", "the", "buffer", "pH", "and", "the", "presence", "of", "C0007026#ent", "<e2>"], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007026", "name": "C0007026#ent", "pos": [16, 17]}}
{"token": ["Sedimentary", "rocks", "tend", "to", "have", "higher", "concentrations", "with", "average", "C0885449#ent", "<e1>", "contents", "of:-recent", "sediments", "5", "-", "200", "mg/kg", ",", "C0007026#ent", "<e2>", "2.7", "mg/kg", ",", "shales", "2.3", "mg/kg", "and", "sandstones", "0.8", "mg/kg", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007026", "name": "C0007026#ent", "pos": [19, 20]}}
{"token": ["C0042165#ent", "<e1>", "AU", ")", ";", "intermediate", "uveitis", "IU", ")", ";", "C0022073#ent", "<e2>", "HCF", ")", ";", "sarcoidosis", ";", "Toxoplasmosis", ")", "."], "h": {"id": "C0042165", "name": "C0042165#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022073", "name": "C0022073#ent", "pos": [10, 11]}}
{"token": ["Omeprazole", "also", "provided", "significantly", "greater", "relief", "from", "daytime", "heartburn", "nighttime", "heartburn", "and", "C0232608#ent", "<e1>", "and", "was", "associated", "with", "decreased", "concomitant", "C0003216#ent", "<e2>", "use", "."], "h": {"id": "C0232608", "name": "C0232608#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003216", "name": "C0003216#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "inhibition", "of", "C0623362#ent", "<e1>", "activity", "or", "more", "general", "suppression", "of", "C0042384#ent", "<e2>", "attractive", "targets", "for", "interventions", "intended", "to", "reduce", "plaque", "rupture", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [12, 13]}}
{"token": ["Of", "377", "men", "attending", "clinics", "for", "the", "treatment", "of", "sexually", "transmitted", "disease", "104", "had", "gonococcal", "urethritis", "72", "had", "definite", "C0018078#ent", "<e1>", "53", "had", "possible", "C0018078#ent", "<e1>", "and", "123", "had", "no", "C0041976#ent", "<e1>", "."], "h": {"id": "C0018078", "name": "C0018078#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0041976", "name": "C0041976#ent", "pos": [30, 31]}}
{"token": ["Of", "these", "men", ",", "141", "had", "gonococcal", "urethritis", "262", "C0018078#ent", "<e1>", "NGU", ")", ",", "and", "74", "showed", "no", "evidence", "of", "C0041976#ent", "<e2>", "."], "h": {"id": "C0018078", "name": "C0018078#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0041976", "name": "C0041976#ent", "pos": [20, 21]}}
{"token": ["The", "C0013227#ent", "<e1>", "caused", "a", "parallel", "shift", "of", "the", "dose-response", "curve", "C1414518#ent", "<e2>", "similar", "to", "that", "of", "the", "verapamil", "on", "isolated", "guinea-pig", "left", "auricle", ",", "indicating", "a", "possible", "Ca-antagonistic", "activity", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414518", "name": "C1414518#ent", "pos": [11, 12]}}
{"token": ["In", "a", "group", "of", "Southeast", "Asian", "patients", ",", "39", "%", "had", "a", "C0037054#ent", "<e1>", "including", "alpha-thalassemia", "trait", "beta-thalassemia", "trait", "hemoglobin", "E", "disease", "and", "C3161174#ent", "<e2>"], "h": {"id": "C0037054", "name": "C0037054#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3161174", "name": "C3161174#ent", "pos": [23, 24]}}
{"token": ["C0012906#ent", "<e1>", "interspecific", "and", "intraspecific", "variation", "between", "the", "C3179066#ent", "<e2>", "DNAs", "and", "therefore", "between", "the", "cytoplasms", "of", "14", "selected", "species", "of", "Triticum", "and", "Aegilops", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [8, 9]}}
{"token": ["The", "chloroplast", "DNA", "fragments", "these", "plasmids", "were", "mapped", "with", "the", "restriction", "endonucleases", "SalI", "SphI", ",", "XhoI", ",", "BglI", "and", "HpaI.", "The", "technique", "overlapping", "hybridization", "or", "chromosome", "walking", "used", "to", "orient", "these", "DNA", "fragments", "a", "C0012906#ent", "<e1>", "of", "the", "C3179066#ent", "<e2>"], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [34, 35]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [38, 39]}}
{"token": ["Analysis", "with", "the", "C0012906#ent", "<e1>", "Sacl", "and", "BstEII", "indicates", "a", "C3179066#ent", "<e2>", "genome", "size", "144", "kb", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [10, 11]}}
{"token": ["To", "address", "the", "biochemical", "and", "physiologic", "effects", "mutant", "C1332803#ent", "<e1>", ",", "we", "disrupted", "either", "the", "mutant", "or", "wild-type", "CTNNB1", "C0002085#ent", "<e2>", "in", "a", "human", "colorectal", "cancer", "cell", "line"], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [19, 20]}}
{"token": ["Serotonin", "syndromes", "been", "reported", "as", "probable", "pharmacodynamic", "consequences", "of", "the", "use", "of", "ergots", "or", "C1567966#ent", "<e1>", "in", "persons", "taking", "C2911696#ent", "<e2>"], "h": {"id": "C1567966", "name": "C1567966#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2911696", "name": "C2911696#ent", "pos": [19, 20]}}
{"token": ["On", "group", "comparisons", ",", "while", "all", "SCAs", "have", "impaired", "C0007760#ent", "<e1>", "the", "cerebellar", "FDG", "metabolism", "was", "most", "severely", "compromised", "in", "C0752121#ent", "<e2>", "."], "h": {"id": "C0007760", "name": "C0007760#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "the", "present", "data", "indicates", "that", "C0525037#ent", "<e1>", "methylation", "correlates", "with", "progression", "of", "C1415097#ent", "<e2>", "significantly", "."], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415097", "name": "C1415097#ent", "pos": [15, 16]}}
{"token": ["C0040479#ent", "<e1>", "been", "observed", "when", "quinidine", ",", "propafenone", ",", "or", "C0543459#ent", "<e2>", "is", "given", "together", "with", "amiodarone", "."], "h": {"id": "C0040479", "name": "C0040479#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [10, 11]}}
{"token": ["There", "was", "wide", "variation", "in", "the", "treatment", "of", "choice", "for", "C0009763#ent", "<e1>", "with", "10", "%", "of", "doctors", "choosing", "a", "C0038317#ent", "<e2>", "containing", "product", "."], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [19, 20]}}
{"token": ["The", "effects", "of", "drug", "exposure", "duration", "and", "of", "heat", "and", "drug", "sequencing", "hyperthermic", "potentiation", "C0026254#ent", "<e1>", "(", "MMC", ")", "and", "cisplatin", "(", "C1420740#ent", "<e2>", ")", "were", "studied", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420740", "name": "C1420740#ent", "pos": [22, 23]}}
{"token": ["Both", "C0991617#ent", "<e1>", "selected", "mutants", "expressing", "C0597979#ent", "<e2>", "but", "this", "was", "more", "common", "with", "ceftazidime", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0597979", "name": "C0597979#ent", "pos": [6, 7]}}
{"token": ["Suitable", "C0991617#ent", "<e1>", "include", "cefoxitin", ",", "cefotetan", ",", "ureidopenicillins", "and", "C0597979#ent", "<e2>", "combinations", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0597979", "name": "C0597979#ent", "pos": [10, 11]}}
{"token": ["Proper", "imaging", "strategy", "is", "of", "paramount", "importance", "in", "the", "diagnosis", "of", "C0016199#ent", "<e1>", "in", "the", "subsequent", "therapy", "planning", "once", "a", "C1456865#ent", "<e2>", "diagnosed", "."], "h": {"id": "C0016199", "name": "C0016199#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1456865", "name": "C1456865#ent", "pos": [20, 21]}}
{"token": ["The", "glomerular", "filtration", "rate", "GFR", ")", "(", "Ccr", ")", ",", "renal", "plasma", "flow", "RPF", ")", "(", "CPAH", ")", "and", "C1419333#ent", "<e1>", "excretion", "rate", "were", "significantly", "lower", "in", "C0027697#ent", "<e2>", "patients", "than", "in", "normal", "subjects"], "h": {"id": "C1419333", "name": "C1419333#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0027697", "name": "C0027697#ent", "pos": [27, 28]}}
{"token": ["High", "glucose", "enhanced", "the", "binding", "of", "nuclear", "proteins", "from", "human", "C0066350#ent", "<e1>", "to", "the", "C1417708#ent", "<e2>", "and", "AP-1", "regulatory", "elements", "of", "the", "LOX-1", "gene", "promoter", "."], "h": {"id": "C0066350", "name": "C0066350#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [14, 15]}}
{"token": ["However", ",", "both", "of", "these", "C0035064#ent", "<e1>", "differed", "from", "C0006400#ent", "<e2>", "in", "the", "r", "effects", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006400", "name": "C0006400#ent", "pos": [9, 10]}}
{"token": ["The", "more", "potent", "C0035064#ent", "<e1>", "such", "as", "C0006400#ent", "<e2>", "appear", "to", "be", "more", "cardiotoxic", "and", "may", "precipitate", "ventricular", "arrhythmias", "ventricular", "fibrillation"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006400", "name": "C0006400#ent", "pos": [7, 8]}}
{"token": ["The", "two", "most", "commonly", "used", "C0035064#ent", "<e1>", "are", "meperidine", ",", "administered", "intravenously", "or", "intramuscularly", ",", "and", "C0006400#ent", "<e2>", ",", "administered", "by", "the", "epidural", "route"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006400", "name": "C0006400#ent", "pos": [16, 17]}}
{"token": ["The", "orphan", "nuclear", "receptor", "liver", "receptor", "homolog", "1", "C1418214#ent", "<e1>", ")", "and", "C1413218#ent", "<e2>", "are", "co-expressed", "in", "liver", "and", "ovary", ",", "suggesting", "that", "C1418214#ent", "<e1>", "might", "control", "the", "expression", "of", "C1413218#ent", "<e2>", "in", "these", "tissues", "."], "h": {"id": "C1413218", "name": "C1413218#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418214", "name": "C1418214#ent", "pos": [8, 9]}}
{"token": ["We", "describe", "a", "case", "in", "which", "it", "was", "caused", "by", "a", "rare", "combination", "of", "a", "C0010051#ent", "<e1>", "fistula", "that", "occurred", "in", "a", "56-year-old", "woman", "with", "concomitant", "C0010308#ent", "<e2>"], "h": {"id": "C0010051", "name": "C0010051#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010308", "name": "C0010308#ent", "pos": [26, 27]}}
{"token": ["This", "model", "of", "accelerated", "C0022658#ent", "<e1>", "albuminuria", "as", "well", "as", "glomerular", "and", "C0041349#ent", "<e2>", "associated", "with", "increased", "renal", "expression", "PDGF-B", ",", "proliferating", "cells", "and", "alpha-smooth", "muscle", "actin-positive", "cells"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0041349", "name": "C0041349#ent", "pos": [12, 13]}}
{"token": ["C0014122#ent", "<e1>", "is", "an", "uncommon", "complication", "of", "C0153252#ent", "<e2>"], "h": {"id": "C0014122", "name": "C0014122#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0153252", "name": "C0153252#ent", "pos": [7, 8]}}
{"token": ["The", "significant", "rise", "in", "the", "percentage", "of", "adults", "susceptible", "to", "diphtheria", "and", "the", "emergence", "of", "non-toxigenic", "Corynebacterium", "diphtheriae", "strains", "the", "causative", "agent", "C0014122#ent", "<e1>", "and", "other", "C0153252#ent", "<e2>", "the", "need", "for", "alternative", "laboratory", "diagnostic", "procedures"], "h": {"id": "C0014122", "name": "C0014122#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0153252", "name": "C0153252#ent", "pos": [26, 27]}}
{"token": ["C2607914#ent", "<e1>", "defined", "as", "paroxysmal", "sneezing", "and", "C1260880#ent", "<e2>", "with", "or", "without", "conjunctivitis", ",", "and", "without", "signs", "of", "infection", "."], "h": {"id": "C2607914", "name": "C2607914#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [7, 8]}}
{"token": ["Atrogenic", "MuRF1", ",", "sarcomeric", "C0056248#ent", "<e1>", "and", "myogenic", "C2985443#ent", "<e2>", "were", "upregulated", "(", "2-fold", ")", "with", "the", "elimination", "of", "contractile", "activity", "Btx", "muscle", "."], "h": {"id": "C0056248", "name": "C0056248#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2985443", "name": "C2985443#ent", "pos": [8, 9]}}
{"token": ["Certain", "tumor", "types", "preferentially", "activate", "either", "cdk4", "or", "C1565313#ent", "<e1>", ",", "suggesting", "that", "these", "C0031727#ent", "<e2>", "may", "not", "be", "equivalently", "oncogenic", "in", "all", "cell", "types"], "h": {"id": "C1565313", "name": "C1565313#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "PIP", "was", "performed", "for", "C1332714#ent", "<e1>", ",", "CD8", ",", "T-cell", "intracellular", "antigen", ",", "and", "C1704913#ent", "<e2>", "expression", "in", "31", "PTCLs", "previously", "studied", "for", "C1332714#ent", "<e1>", "and", "CD8", "by", "flow", "cytometry"], "h": {"id": "C1704913", "name": "C1704913#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332714", "name": "C1332714#ent", "pos": [6, 7]}}
{"token": ["Campomelic", "dysplasia", "CD", ")", "is", "a", "C1302790#ent", "<e1>", "accompanied", "by", "C2748896#ent", "<e2>", "sex", "reversal", "."], "h": {"id": "C1302790", "name": "C1302790#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2748896", "name": "C2748896#ent", "pos": [10, 11]}}
{"token": ["Two", "patients", "were", "affected", "with", "C0086795#ent", "<e1>", "mucopolysaccharidosis", "IS", "1", "had", "mucopolysaccharidosis", "IV", "A", "4", "presented", "C0026709#ent", "<e2>"], "h": {"id": "C0086795", "name": "C0086795#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0026709", "name": "C0026709#ent", "pos": [16, 17]}}
{"token": ["Under", "long-term", "administration", "of", "Gentamycin", "or", "C0011806#ent", "<e1>", "the", "excretion", "of", "C3540790#ent", "<e2>", "already", "reduced", "during", "therapy", "."], "h": {"id": "C0011806", "name": "C0011806#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["An", "aqueous", "two-phase", "system", "on", "the", "two", "polymers", "poly(ethylene", "glycol", ")", "and", "C0011806#ent", "<e1>", "has", "been", "used", "for", "the", "fractionation", "of", "cellulase", "C3540790#ent", "<e2>", "present", "in", "culture", "liquid", "by", "fermentation", "with", "Trichoderma", "reesei"], "h": {"id": "C0011806", "name": "C0011806#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [22, 23]}}
{"token": ["Peptide", "inhibitors", "caspases", "2", "3", ",", "and", "9", ",", "but", "not", "of", "C0534519#ent", "<e1>", "caused", "significant", "C0242912#ent", "<e2>", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [16, 17]}}
{"token": ["These", "results", "indicate", "that", "C1705969#ent", "<e1>", "intoxication", "impairs", "C1420234#ent", "<e2>", "expression", "in", "the", "proximal", "tubule", "thereby", "reducing", "the", "capacity", "for", "bicarbonate", "reabsorption", "leading", "to", "bicarbonaturia", "in", "an", "intact", "animal", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420234", "name": "C1420234#ent", "pos": [8, 9]}}
{"token": ["Heterodimerization", "of", "Max", "with", "the", "C0812219#ent", "<e1>", "Myc", "and", "the", "C4255437#ent", "<e2>", "Mxi1", "enables", "these", "factors", "to", "bind", "E-box", "sites", "in", "DNA", "and", "control", "genes", "in", "cell", "proliferation", "differentiation", "."], "h": {"id": "C0812219", "name": "C0812219#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4255437", "name": "C4255437#ent", "pos": [10, 11]}}
{"token": ["Additionally", ",", "the", "hepatic", "uptake", "of", "PL", "and", "C0010762#ent", "<e1>", "P-450", ")", "content", "and", "uridine", "5'-diphosphoglucuronyltransferase", "C3812293#ent", "<e2>", ")", "activity", "in", "liver", "were", "measured", "after", "glucose", "intake"], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3812293", "name": "C3812293#ent", "pos": [16, 17]}}
{"token": ["These", "data", "suggest", "that", "rat", "nasal", "tissue", "contain", "multiple", "forms", "of", "C0010762#ent", "<e1>", "of", "EH", "and", "C3812293#ent", "<e2>", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3812293", "name": "C3812293#ent", "pos": [16, 17]}}
{"token": ["We", "previously", "detected", "polymorphisms", "in", "the", "52-kDa", "Ro/SSA", "gene", "SSA1", ")", "with", "C0012906#ent", "<e1>", "one", "of", "which", "is", "strongly", "associated", "with", "presence", "of", "C0024141#ent", "<e2>", "(", "P", "<", "0.0005", ")", "in", "African", "Americans"], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [23, 24]}}
{"token": ["This", "PKA-dependent", "Rap1", "activation", "does", "not", "require", "C0038085#ent", "<e1>", "but", ",", "in", "contrast", "to", "C0525678#ent", "<e2>", ",", "is", "sensitive", "to", "genistein", ",", "indicating", "the", "involvement", "of", "a", "tyrosine", "kinase-dependent", "mechanism", "."], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [14, 15]}}
{"token": ["PC1", "(", "PC3", ")", "and", "C1418600#ent", "<e1>", ",", "members", "of", "the", "mammalian", "family", "of", "C0135615#ent", "<e2>", "to", "the", "yeast", "Kex2", "gene", "product", ",", "are", "both", "expressed", "in", "pancreatic", "islets", "Langerhans", "."], "h": {"id": "C1418600", "name": "C1418600#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0135615", "name": "C0135615#ent", "pos": [14, 15]}}
{"token": ["To", "study", "evolutionary", "relationship", "C2606397#ent", "<e1>", "species", ",", "we", "used", "a", "cDNA", "probe", "human", "C1413806#ent", "<e2>", "to", "investigate", "the", "species", "distribution", "of", "C2606397#ent", "<e1>", "and", "designed", "oligodeoxynucleotide", "primers", "investigate", "the", "genomic", "organization", "the", "three", "domains", "of", "active", "sites"], "h": {"id": "C1413806", "name": "C1413806#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2606397", "name": "C2606397#ent", "pos": [4, 5]}}
{"token": ["C3494348#ent", "<e1>", "hexamethonium", "and", "C0004259#ent", "<e2>", ",", "completely", "abolished", "the", "acid", "secretion", "induced", "by", "capsaicin", "whereas", "secretin", "only", "partially", "reduced", "such", "a", "response", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [4, 5]}}
{"token": ["The", "systemic", "administration", "the", "alpha-adrenergic", "blocker", "phentolamine", "prevented", "the", "decrease", "in", "intraocular", "pressure", "systemically", "administered", "C3494348#ent", "<e1>", "of", "cholinergic", "(", "C0004259#ent", "<e2>", ")", "or", "beta-adrenergic", "(", "propranolol", ")", "activity", "had", "no", "effect"], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [20, 21]}}
{"token": ["Both", "INS", "and", "AA", "decreased", "the", "binding", "of", "C2984182#ent", "<e1>", "to", "eIF4E", "and", "increased", "eIF4E", "binding", "to", "C2826592#ent", "<e2>", "these", "effects", "were", "greater", "in", "6-day-old", "than", "in", "26-day-old", "pigs", "."], "h": {"id": "C2984182", "name": "C2984182#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2826592", "name": "C2826592#ent", "pos": [17, 18]}}
{"token": ["This", "study", "has", "examined", "the", "effects", "of", "C1864904#ent", "<e1>", "expression", "of", "the", "CRH", ",", "arginine", "vasopressin", "and", "C1337111#ent", "<e2>", "genes", "and", "corresponding", "peptides", "in", "freely", "moving", ",", "unanesthetized", ",", "male", "Sprague-Dawley", "rats"], "h": {"id": "C1864904", "name": "C1864904#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [17, 18]}}
{"token": ["An", "C0376622#ent", "<e1>", "vector", "containing", "the", "Epstein-Barr", "virus", "C0149678#ent", "<e2>", ")", "origin", "of", "replication", "(", "OriP", ")", "and", "its", "nuclear", "retention", "protein", "EBNA-1", ")", "was", "transfected", "into", "human", "(", "KB-3", "-", "1", ")", "cells", "."], "h": {"id": "C0376622", "name": "C0376622#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [8, 9]}}
{"token": ["C0041487#ent", "<e1>", "inducibility", "was", "reexpressed", "independently", "of", "basal", "activity", "and", "the", "C0027203#ent", "<e2>", "produced", "by", "the", "reexpressing", "hybrid", "cells", "precipitated", "by", "a", "specific", "antiserum", "."], "h": {"id": "C0041487", "name": "C0041487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["The", "Ru(bpy)(3)-protohemins", "were", "incorporated", "into", "the", "heme", "crevice", "of", "apomyoglobin", "(", "apo-Mb", ")", "to", "yield", "semisynthetic", "C0221060#ent", "<e1>", "carrying", "Ru(bpy)(3", ")", "as", "a", "C3826984#ent", "<e2>", "(", "Ru(bpy)(3)-Mb", ")", "."], "h": {"id": "C0221060", "name": "C0221060#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3826984", "name": "C3826984#ent", "pos": [23, 24]}}
{"token": ["In", "conclusion", ",", "the", "data", "presented", "show", "that", "C0289499#ent", "<e1>", "corresponds", "to", "a", "previously", "described", "C1335554#ent", "<e2>", "and", "that", "this", "molecule", "is", "involved", "in", "signal", "transduction", "lymphocytes", "."], "h": {"id": "C0289499", "name": "C0289499#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [15, 16]}}
{"token": ["However", ",", "considerable", "experimental", "data", "that", "the", "abnormal", "regulation", "of", "cytokines", "contributes", "to", "such", "siseases", "as", "C3899281#ent", "<e1>", "systemic", "lupus", "erythematosus", "scleroderma", ",", "and", "C0011633#ent", "<e2>", "."], "h": {"id": "C3899281", "name": "C3899281#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011633", "name": "C0011633#ent", "pos": [24, 25]}}
{"token": ["The", "purified", "C1571454#ent", "<e1>", "was", "lysed", "to", "C0030956#ent", "<e2>", ",", "which", "were", "sequenced", ",", "leading", "to", "the", "full-length", "cDNA", "sequencing", "and", "its", "expression", "in", "Escherichia", "coli"], "h": {"id": "C1571454", "name": "C1571454#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [7, 8]}}
{"token": ["Roxithromycin", "inhibited", "the", "C0030306#ent", "<e1>", "production", "at", "higher", "concentrations", "than", "C1705457#ent", "<e2>", "without", "inhibiting", "the", "proliferation", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705457", "name": "C1705457#ent", "pos": [10, 11]}}
{"token": ["The", "transplanted", "C0206141#ent", "<e1>", "cell-derived", "cardiomyocytes", "paced", "the", "hearts", "of", "swine", "with", "complete", "C0151517#ent", "<e2>", "as", "assessed", "by", "detailed", "three-dimensional", "electrophysiological", "mapping", "and", "histopathological", "examination", "."], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0151517", "name": "C0151517#ent", "pos": [13, 14]}}
{"token": ["The", "gradual", "decrease", "of", "NAD", "observed", "in", "primary", "cultured", "C0669372#ent", "<e1>", ",", "was", "partially", "inhibited", "by", "the", "addition", "of", "poly(ADP-ribose)", "polymerase", "C3850174#ent", "<e2>"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3850174", "name": "C3850174#ent", "pos": [21, 22]}}
{"token": ["The", "nevoid", "basal", "cell", "carcinoma", "syndrome", "NBCCS", ")", ",", "also", "known", "as", "Gorlin-Goltz", "syndrome", "is", "a", "rare", "C0018939#ent", "<e1>", "inherited", "according", "to", "an", "C2936739#ent", "<e2>", "."], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [23, 24]}}
{"token": ["The", "cross-sectional", "area", "function", "the", "C0751901#ent", "<e1>", "calculated", "using", "pitch", "synchronous", "autoregressive", "moving", "average", "(", "C1948055#ent", "<e2>", ")", "analysis", "."], "h": {"id": "C0751901", "name": "C0751901#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1948055", "name": "C1948055#ent", "pos": [15, 16]}}
{"token": ["These", "studies", "provided", "the", "support", "for", "the", "initiation", "of", "a", "clinical", "trial", "retroviral-mediated", "gene", "transfer", "of", "C3889161#ent", "<e1>", "in", "two", "patients", "with", "the", "severe", "deficiency", "phenotype", "or", "C1706333#ent", "<e2>", "."], "h": {"id": "C3889161", "name": "C3889161#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706333", "name": "C1706333#ent", "pos": [27, 28]}}
{"token": ["However", ",", "it", "is", "not", "clear", "whether", "C3889161#ent", "<e1>", "of", "all", "three", "beta2-integrins", ",", "LFA-1", ",", "C1706333#ent", "<e2>", ",", "and", "CR4", ",", "mediates", "Lkt-induced", "cytolysis", "."], "h": {"id": "C3889161", "name": "C3889161#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706333", "name": "C1706333#ent", "pos": [16, 17]}}
{"token": ["Blockade", "of", "neuronal", "amine", "transport", "C0011685#ent", "<e1>", "reduced", "the", "release", "of", "radioactivity", "evoked", "by", "C0039245#ent", "<e2>", "from", "atria", "but", "not", "that", "evoked", "from", "artery", "preparations"], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039245", "name": "C0039245#ent", "pos": [14, 15]}}
{"token": ["There", "was", "no", "protective", "influence", "of", "DPL", "with", "C0003949#ent", "<e1>", "either", "for", "BAM", "or", "for", "C1419195#ent", "<e2>", "."], "h": {"id": "C0003949", "name": "C0003949#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419195", "name": "C1419195#ent", "pos": [15, 16]}}
{"token": ["An", "economic", "evaluation", "performed", "analyzing", "direct", "medical", "costs", "Canada", "for", "the", "treatment", "of", "C0035457#ent", "<e1>", "PAR", ")", "with", "C0054201#ent", "<e2>", "aqueous", "nasal", "spray", "fluticasone", "propionate", "nasal", "spray"], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0054201", "name": "C0054201#ent", "pos": [18, 19]}}
{"token": ["C0012586#ent", "<e1>", "does", "not", "affect", "the", "pharmacodynamic", "response", "C0001962#ent", "<e2>", "(", "ethanol", ")", ",", "glibenclamide", "(", "glyburide", ")", ",", "oral", "anti-coagulants", "furosemide", "(", "frusemide", ")", "."], "h": {"id": "C0012586", "name": "C0012586#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [8, 9]}}
{"token": ["The", "most", "common", "endocrine", "disorders", "as", "C0920350#ent", "<e1>", "type", "2", "diabetes", "mellitus", "osteoporosis", ",", "growth", "disorders", "and", "obesity", "have", "all", "major", "C1136365#ent", "<e2>", "but", "these", "are", "mostly", "unknown", "."], "h": {"id": "C0920350", "name": "C0920350#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [21, 22]}}
{"token": ["Both", "over", "and", "under", "expression", "of", "the", "C1708842#ent", "<e1>", "and", "BUB1", "mitotic", "spindle", "checkpoint", "genes", "detected", "at", "all", "C0004763#ent", "<e2>", "histological", "stages", "no", "apparent", "selective", "trend", "with", "neoplastic", "progression"], "h": {"id": "C1708842", "name": "C1708842#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004763", "name": "C0004763#ent", "pos": [18, 19]}}
{"token": ["Patch", "testing", "with", "a", "relevant", "panel", "of", "C0162820#ent", "<e1>", "the", "ultimate", "confirmatory", "test", "C0002873#ent", "<e2>", "."], "h": {"id": "C0162820", "name": "C0162820#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002873", "name": "C0002873#ent", "pos": [13, 14]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "evaluate", "the", "role", "of", "the", "C1705691#ent", "<e1>", "NERF", "in", "the", "regulation", "of", "the", "Tie1", "and", "C1705001#ent", "<e2>", "genes", "during", "chicken", "blood", "vessel", "development", "."], "h": {"id": "C1705691", "name": "C1705691#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705001", "name": "C1705001#ent", "pos": [22, 23]}}
{"token": ["C0008055#ent", "<e1>", "is", "a", "disease", "of", "C0043528#ent", "<e2>", "importance", "affecting", "man", "with", "non-human", "primates", "a", "main", "reservoir", "."], "h": {"id": "C0008055", "name": "C0008055#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [6, 7]}}
{"token": ["The", "specific", "activities", "of", "2", "C0016964#ent", "<e1>", ",", "a", "sialytransferase", ",", "and", "an", "C0130707#ent", "<e2>", "were", "elevated", "after", "1", "month", "and", "after", "2", "months", "of", "daily", "subcutaneous", "injections", "methacholine", "chloride"], "h": {"id": "C0016964", "name": "C0016964#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0130707", "name": "C0130707#ent", "pos": [13, 14]}}
{"token": ["These", "data", "suggest", "that", "BMP", "signaling", "plays", "an", "important", "role", "in", "regulating", "cell", "proliferation", "controls", "the", "size", "of", "anagen", "C2745948#ent", "<e1>", "by", "modulating", "the", "expression", "of", "cell-cycle-associated", "genes", "in", "hair", "matrix", "C0022575#ent", "<e2>", "."], "h": {"id": "C2745948", "name": "C2745948#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022575", "name": "C0022575#ent", "pos": [31, 32]}}
{"token": ["This", "C1704824#ent", "<e1>", "encodes", "the", "first", "433", "C3539947#ent", "<e2>", "the", "extracellular", "domain", "ECD", ")", "."], "h": {"id": "C1704824", "name": "C1704824#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [7, 8]}}
{"token": ["C1421563#ent", "<e1>", "also", "identified", "in", "synapses", "by", "immunofluorescent", "double-staining", "with", "C1420543#ent", "<e2>", "located", "in", "the", "pinceau", "around", "the", "Purkinje", "cells", "and", "in", "glomeruli", "."], "h": {"id": "C1421563", "name": "C1421563#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420543", "name": "C1420543#ent", "pos": [10, 11]}}
{"token": ["Since", "ingestion", "of", "foods", "that", "are", "high", "in", "fat", "and", "C0242209#ent", "<e1>", "is", "associated", "with", "increased", "incidence", "of", "C0011847#ent", "<e2>", ",", "we", "examined", "if", "Wrn", "mutations", "might", "affect", "metabolic", "response", "a", "diabetogenic", "diet"], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [18, 19]}}
{"token": ["We", "measured", "the", "C0242209#ent", "<e1>", "sural", "nerves", "11", "controls", ",", "21", "conventionally", "treated", "patients", "with", "C0011847#ent", "<e2>", "and", "neuropathy", ",", "and", "4", "diabetics", "without", "neuropathy", "."], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [15, 16]}}
{"token": ["Isolates", "3", "and", "5", "showed", "C1512488#ent", "<e1>", "patterns", "for", "malate", "dehydrogenase", "C0017759#ent", "<e2>"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017759", "name": "C0017759#ent", "pos": [11, 12]}}
{"token": ["To", "evaluate", "the", "safety", "and", "efficiency", "of", "C0014582#ent", "<e1>", "in", "the", "treatment", "of", "C0022354#ent", "<e2>", "MOJ", ")", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022354", "name": "C0022354#ent", "pos": [13, 14]}}
{"token": ["A", "role", "for", "plasma", "membrane", "C0001473#ent", "<e1>", "activation", "in", "the", "regulation", "of", "the", "intracellular", "pH", "(", "C1704947#ent", "<e2>", ")", "of", "cells", "grown", "with", "octanoic", "acid", "not", "proven", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [16, 17]}}
{"token": ["Despite", "the", "apparent", "similarity", "of", "structure", "and", "functional", "location", "of", "the", "C0024188#ent", "<e1>", "similarity", "of", "the", "heme", "binding", "regions", "their", "respective", "apoproteins", ",", "C1415491#ent", "<e2>", "cytochrome", "c1", "heme", "lyase", "have", "different", "and", "nonoverlapping", "substrate", "specificities", "."], "h": {"id": "C0024188", "name": "C0024188#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415491", "name": "C1415491#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "have", "analyzed", "the", "mode", "of", "import", "and", "folding", "of", "the", "two", "C0024188#ent", "<e1>", "the", "yeast", "Saccharomyces", "cerevisiae", "namely", "of", "C1415491#ent", "<e2>", "of", "cytochrome", "c1", "heme", "lyase"], "h": {"id": "C0024188", "name": "C0024188#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1415491", "name": "C1415491#ent", "pos": [22, 23]}}
{"token": ["C0019342#ent", "<e1>", "a", "common", "C0036916#ent", "<e2>", "that", "is", "caused", "mostly", "by", "Herpes", "simplex", "virus", "type", "2", "HSV-2", ")", "."], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [4, 5]}}
{"token": ["The", "aim", "was", "to", "investigate", "the", "controversial", "issue", "of", "C0268731#ent", "<e1>", "permselectivity", "in", "animals", "exposed", "to", "enzymes", ",", "hyaluronidase", ",", "and", "C0062507#ent", "<e2>", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0062507", "name": "C0062507#ent", "pos": [21, 22]}}
{"token": ["A", "single", "large", "dose", "(", "200", "mg/kg", ")", "of", "C0010583#ent", "<e1>", "(", "Cy", ")", "caused", "C1332162#ent", "<e2>"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332162", "name": "C1332162#ent", "pos": [15, 16]}}
{"token": ["A", "simple", "column", "chromatographic", "method", "determination", "of", "C0546863#ent", "<e1>", "(", "C1539357#ent", "<e2>", ")", "in", "pharmaceutical", "preparations", "C1539357#ent", "<e2>", "in", "combination", "with", "other", "anti-TB", "drugs", "is", "presented", "."], "h": {"id": "C0546863", "name": "C0546863#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539357", "name": "C1539357#ent", "pos": [10, 11]}}
{"token": ["C1257966#ent", "<e1>", "have", "the", "potential", "to", "modulate", "inflammation", "by", "inhibition", "of", "C0387583#ent", "<e2>", "(", "COX-2", ")", "transcription", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "C1415311#ent", "<e1>", "was", "hydrolyzed", "by", "C0030940#ent", "<e2>", "added", "to", "osmotically", "stabilized", "protoplasts", "."], "h": {"id": "C1415311", "name": "C1415311#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [7, 8]}}
{"token": ["We", "have", "studied", "C0872913#ent", "<e1>", "and", "B-cell", "responses", "antigens", "of", "Candida", "albicans", "18", "patients", "suffering", "from", "C0006845#ent", "<e2>"], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006845", "name": "C0006845#ent", "pos": [16, 17]}}
{"token": ["We", "describe", "findings", "of", "C0238902#ent", "<e1>", "on", "positron-emission", "tomography", "CT", "that", "further", "support", "the", "classification", "of", "C0238902#ent", "<e1>", "as", "a", "distinct", "C1290884#ent", "<e1>"], "h": {"id": "C0238902", "name": "C0238902#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [21, 22]}}
{"token": ["From", "Helsingborg", "sludge", "the", "C3541394#ent", "<e1>", "extracted", "about", "40", "%", "more", "of", "C0221271#ent", "<e2>", "than", "from", "Damhus\u00e5en", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221271", "name": "C0221271#ent", "pos": [12, 13]}}
{"token": ["Our", "findings", "indicate", "that", "agonist", "binding", "to", "muscarinic", "receptors", "voltage", "dependent", "that", "this", "C1951340#ent", "<e1>", "is", "mediated", "by", "G-protein(s", ")", ",", "and", "that", "C0242947#ent", "<e2>", "induce", "opening", "of", "Na+", "channels", "."], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242947", "name": "C0242947#ent", "pos": [23, 24]}}
{"token": ["Ras", "mediates", "diverse", "effects", "via", "its", "diverse", "effector", "pathways", "which", "may", "include", "other", "members", "of", "the", "C0242853#ent", "<e1>", "as", "RhoA", "and", "C3274857#ent", "<e2>", "."], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3274857", "name": "C3274857#ent", "pos": [21, 22]}}
{"token": ["Moreover", ",", "we", "identify", "that", "two", "C0242853#ent", "<e1>", ",", "Ras", "and", "C3274857#ent", "<e2>", ",", "are", "important", "regulators", "of", "NFAT", ",", "and", "therefore", "of", "cytokine", "expression", "in", "mast", "cells"], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3274857", "name": "C3274857#ent", "pos": [11, 12]}}
{"token": ["Gabapentin", "(", "C3538683#ent", "<e1>", ")", "is", "a", "new", "C0003299#ent", "<e2>", "for", "clinical", "treatment", "partial", "seizures", "in", "the", "USA", "."], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [8, 9]}}
{"token": ["(", "1", ")", "Partially", "purified", "preparations", "of", "spinach", "(", "Spinacia", "oleracea", "L.", "leaf", "sucrose-phosphate", "synthase", "C1843919#ent", "<e1>", ")", "contain", "an", "endogenous", "C0010536#ent", "<e2>", "phosphorylates", "and", "inactivates", "the", "enzyme", "with", "[gamma-32P]ATP", "."], "h": {"id": "C1843919", "name": "C1843919#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [21, 22]}}
{"token": ["Three", "additional", "newborns", "who", "had", "not", "received", "transfusions", "with", "the", "infected", "unit", "also", "acquired", "C0019158#ent", "<e1>", "neonates", "with", "C0019159#ent", "<e2>", "all", "asymptomatic", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [18, 19]}}
{"token": ["After", "C0001641#ent", "<e1>", "exercise", "collateral", "resistance", "decreased", "by", "46", "%", "(", "C1414863#ent", "<e2>", "+", "/-", "12", ")", "."], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [11, 12]}}
{"token": ["Under", "these", "conditions", ",", "the", "concentration", "of", "the", "C1335439#ent", "<e1>", "increased", "while", "the", "concentrations", "of", "the", "C1335440#ent", "<e2>", "decreased", "."], "h": {"id": "C1335439", "name": "C1335439#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [16, 17]}}
{"token": ["We", "have", "investigated", "the", "potential", "antioxidant", "effects", "C2936882#ent", "<e1>", ",", "estrogen", "derivatives", "and", "the", "SERMs", "Raloxifene", "and", "C0065279#ent", "<e2>", "in", "the", "prevention", "of", "oxidative", "stress", "induced", "apoptosis", "in", "the", "osteocyte", "like", "cell", "line", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0065279", "name": "C0065279#ent", "pos": [17, 18]}}
{"token": ["Recessive", "mutations", "in", "two", "genes", ",", "daf-2", "and", "C3539760#ent", "<e1>", ",", "extend", "the", "lifespan", "of", "C0949990#ent", "<e2>", "."], "h": {"id": "C3539760", "name": "C3539760#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0949990", "name": "C0949990#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "heroin-seeking", "behaviour", "still", "present", "for", "a", "few", "days", "following", "C3536852#ent", "<e1>", "primings", ",", "indicating", "a", "long-lasting", "effect", "of", "C0006864#ent", "<e2>", "on", "responding", "for", "heroin", "."], "h": {"id": "C3536852", "name": "C3536852#ent", "pos": [11, 12]}, "relation": "has_chemical_structure", "t": {"id": "C0006864", "name": "C0006864#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "the", "upregulation", "of", "CS", "and", "C1868117#ent", "<e1>", ",", "but", "not", "C1863753#ent", "<e2>", "which", "is", "down", "regulated", "by", "chronic", "ethanol", ",", "may", "account", "for", "the", "appearance", "of", "asialoconjugates", "in", "alcoholics", "."], "h": {"id": "C1868117", "name": "C1868117#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1863753", "name": "C1863753#ent", "pos": [12, 13]}}
{"token": ["Not", "only", "narcotics", "and", "C0304402#ent", "<e1>", ",", "but", "also", "many", "C0949738#ent", "<e2>", "and", "barbituarates", "are", "excreted", "in", "the", "sweat", "and", "detected", "quantitatively", "by", "the", "same", "principles", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0949738", "name": "C0949738#ent", "pos": [10, 11]}}
{"token": ["We", "proposed", "using", "the", "term", "pituitary", "adenoma", "predisposition", "(", "C1367456#ent", "<e1>", ")", "to", "describe", "a", "person", "with", "an", "C0162565#ent", "<e2>", "germline", "mutation"], "h": {"id": "C1367456", "name": "C1367456#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162565", "name": "C0162565#ent", "pos": [18, 19]}}
{"token": ["One", "patient", "with", "early", "presentation", "thrombolytic", "therapy", "and", "all", "the", "patients", "were", "treated", "with", "aspirin", ",", "beta-blocker", ",", "C3536793#ent", "<e1>", "statin", ",", "low-molecular-weight", "heparin", "parenteral", "nitrate", "and", "clopidogrel", "for", "acute", "coronary", "syndrome", "and", "C0020402#ent", "<e2>", "for", "essential", "thrombocytosis", "."], "h": {"id": "C3536793", "name": "C3536793#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [33, 34]}}
{"token": ["Channel", "phosphorylation", "regulation", "were", "facilitated", "by", "submembrane", "targeting", "of", "C0033640#ent", "<e1>", "PKA", ")", ",", "through", "association", "with", "an", "C1412314#ent", "<e2>", "AKAP79", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412314", "name": "C1412314#ent", "pos": [18, 19]}}
{"token": ["Despite", "these", "observations", ",", "treatment", "with", "the", "mitochondrial", "stabilizer", "C0005982#ent", "<e1>", "or", "with", "C1413138#ent", "<e2>", ",", "known", "to", "degrade", "H(2)O(2", ")", ",", "fails", "to", "reverse", "VAA-I-induced", "apoptosis", "."], "h": {"id": "C0005982", "name": "C0005982#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [13, 14]}}
{"token": ["Posturographic", "measurements", "revealed", "a", "higher", "incidence", "of", "anteroposterior", "sway", "direction", "in", "C0393520#ent", "<e1>", "as", "compared", "with", "FA", ",", "suggesting", "a", "C0007758#ent", "<e2>", "C0393520#ent", "<e1>", "."], "h": {"id": "C0393520", "name": "C0393520#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [20, 21]}}
{"token": ["This", "portion", "of", "C2697656#ent", "<e1>", "was", "associated", "with", "C3715113#ent", "<e2>", ",", "indicating", "that", "the", "interaction", "with", "C3715113#ent", "<e2>", "may", "also", "proceed", "with", "a", "part", "of", "C2697656#ent", "<e1>", "released", "from", "bacteria", "."], "h": {"id": "C3715113", "name": "C3715113#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [3, 4]}}
{"token": ["The", "C0085151#ent", "<e1>", "APP", ")", "is", "directly", "and", "efficiently", "cleaved", "by", "C0010656#ent", "<e2>", "during", "apoptosis", ",", "resulting", "in", "elevated", "beta-amyloid", "peptide", "formation", "."], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [11, 12]}}
{"token": ["The", "C0085151#ent", "<e1>", "APP", ")", "is", "directly", "and", "efficiently", "cleaved", "by", "C0010656#ent", "<e2>", "during", "apoptosis", ",", "resulting", "in", "elevated", "amyloid-beta", "(", "A", "beta", ")", "peptide", "formation", "."], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [11, 12]}}
{"token": ["The", "removal", "of", "C0086376#ent", "<e1>", "allowed", "the", "determination", "of", "fairly", "C0019139#ent", "<e2>", "hyaluronan", ",", "compared", "to", "untreated", "samples", "for", "which", "hyaluronan", "and", "protein", "peaks", "overlap", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [10, 11]}}
{"token": ["Recently", ",", "we", "saw", "a", "patient", "who", "had", "C0221243#ent", "<e1>", "hyperglucagonaemia", ",", "and", "C1623038#ent", "<e2>", "of", "the", "liver", "with", "no", "evidence", "of", "pancreatic", "tumour", "alive", "or", "at", "autopsy", "."], "h": {"id": "C0221243", "name": "C0221243#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [13, 14]}}
{"token": ["UDP-N-acetylmuramoyl-l-alanyl-d-glutamate", ":", "meso-diaminopimelate", "ligase", "a", "C4283758#ent", "<e1>", "catalyzes", "the", "addition", "of", "C0011961#ent", "<e2>", "nucleotide", "precursor", "UDP-N-acetylmuramoyl-l-alanyl-d-glutamate", "in", "the", "biosynthesis", "of", "bacterial", "cell-wall", "peptidoglycan", "."], "h": {"id": "C4283758", "name": "C4283758#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011961", "name": "C0011961#ent", "pos": [11, 12]}}
{"token": ["A", "case", "is", "reported", "of", "C0398650#ent", "<e1>", "a", "narcotics", "addict", "antibodies", "against", "human", "C0021051#ent", "<e2>", "HIV", ")", "."], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [13, 14]}}
{"token": ["However", ",", "supplement", "of", "anti-IL-10", "mAb", "caused", "upregulation", "of", "certain", "C1417679#ent", "<e1>", "such", "as", "IL-11", ",", "leukaemia", "inhibitory", "factor", "receptor", "C1334339#ent", "<e2>", ")", "and", "syndecan-1", "in", "IL-10R-expressing", "cell", "lines"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334339", "name": "C1334339#ent", "pos": [20, 21]}}
{"token": ["We", "present", "a", "28", "year-old", "woman", "with", "classical", "systemic", "of", "C0221033#ent", "<e1>", "prominent", "neurological", "dysfunctions/deficits", "including", "distal", "muscular", "atrophy", "progressive", "muscle", "weakness", "C0235394#ent", "<e2>", "of", "both", "legs", ",", "sensibility", "dysfunction", "hyperreflexia", "and", "autonomic", "dysfunction", "with", "excessive", "sweating", "."], "h": {"id": "C0221033", "name": "C0221033#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0235394", "name": "C0235394#ent", "pos": [22, 23]}}
{"token": ["However", ",", "TGF-beta3", "selectively", "disrupts", "Sertoli-germ", "cell", "adhesion", "in", "the", "seminiferous", "epithelium", "facilitate", "germ", "cell", "migration", "without", "compromising", "BTB", "when", "C1420610#ent", "<e1>", "interacts", "only", "with", "adaptor", "C1422519#ent", "<e2>", "."], "h": {"id": "C1420610", "name": "C1420610#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1422519", "name": "C1422519#ent", "pos": [26, 27]}}
{"token": ["Plantar", "skin", "temperature", "monitoring", "during", "the", "procedure", "of", "percutaneous", "radiofrequency-thermolesion", "of", "the", "sympathetic", "chain", "PRFS", ")", "in", "patients", "with", "C0162819#ent", "<e1>", "patients", "with", "C0024031#ent", "<e2>", "signs", "of", "sympathetic", "irritation", "showed", "a", "distinct", "difference", "."], "h": {"id": "C0162819", "name": "C0162819#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [23, 24]}}
{"token": ["Six", "C0030956#ent", "<e1>", "were", "obtained", ":", "phalloidin", "and", "five", "new", "C0030956#ent", "<e1>", "recently", "identified", "by", "Faulstich", "as", "C0078337#ent", "<e1>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0078337", "name": "C0078337#ent", "pos": [17, 18]}}
{"token": ["Three", "groups", "of", "C0030956#ent", "<e1>", "have", "been", "obtained", ":", "C0078337#ent", "<e2>", ",", "amaninamide", "and", "phalloidin", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0078337", "name": "C0078337#ent", "pos": [9, 10]}}
{"token": ["We", "have", "incubated", "neuronal", "cultures", "with", "C0991617#ent", "<e1>", "that", "increase", "C1419070#ent", "<e2>", "hydrolysis", "and", "have", "determined", "the", "effects", "on", "ANG", "II-specific", "binding", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419070", "name": "C1419070#ent", "pos": [10, 11]}}
{"token": ["Antigen", "receptor-triggered", "Ca2", "+", "mobilization", ",", "cytokine", "production", "and", "receptor", "clustering", "can", "be", "C1516876#ent", "<e1>", "uncoupled", "in", "C1332672#ent", "<e2>", "mutant", "T", "cells"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332672", "name": "C1332672#ent", "pos": [17, 18]}}
{"token": ["To", "confirm", "that", "the", "effects", "of", "LY294002", "on", "C0549410#ent", "<e1>", "attributable", "to", "inhibition", "of", "C0812228#ent", "<e2>", ",", "we", "transiently", "transfected", "breast", "cancer", "cells", "dominant-negative", "C0812228#ent", "<e2>", "and", "observed", "increased", "doxorubicin-induced", "apoptosis", "."], "h": {"id": "C0549410", "name": "C0549410#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [14, 15]}}
{"token": ["The", "full-length", "Ab-Rel", "cDNA", "consists", "of", "1943", "bp", "with", "an", "C0013570#ent", "<e1>", "encoding", "a", "584", "C1874187#ent", "<e2>"], "h": {"id": "C0013570", "name": "C0013570#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1874187", "name": "C1874187#ent", "pos": [15, 16]}}
{"token": ["The", "C0287531#ent", "<e1>", "has", "recently", "been", "identified", "as", "the", "C0079427#ent", "<e2>", "frequently", "mutated", "and/or", "deleted", "in", "human", "tumors", "."], "h": {"id": "C0287531", "name": "C0287531#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [9, 10]}}
{"token": ["The", "region", "of", "C3889380#ent", "<e1>", "forms", "an", "amphipathic", "helix", "which", "is", "induced", "by", "C0623128#ent", "<e2>", "binding", ",", "and", "C0623128#ent", "<e2>", "possesses", "a", "large", "hydrophobic", "cleft", "by", "EF-hand", "helices"], "h": {"id": "C3889380", "name": "C3889380#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0623128", "name": "C0623128#ent", "pos": [13, 14]}}
{"token": ["Treatment", "with", "prednisolone", "and", "C0010583#ent", "<e1>", "resulted", "in", "the", "disappearance", "of", "the", "C0037284#ent", "<e2>", "the", "improvement", "of", "laboratory", "data"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [12, 13]}}
{"token": ["It", "has", "also", "been", "reported", "previously", "that", "both", "lithium", "and", "inositol", "mildly", "up-regulate", "C3812826#ent", "<e1>", "(", "encoding", "mammalian", "C0163342#ent", "<e2>", "expression", "in", "human", "cells"], "h": {"id": "C3812826", "name": "C3812826#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0163342", "name": "C0163342#ent", "pos": [18, 19]}}
{"token": ["Lower", "concentrations", "C0378220#ent", "<e1>", "(", "3", "microM", ")", "were", "without", "effect", "on", "the", "C0022614#ent", "<e2>", "response", "."], "h": {"id": "C0378220", "name": "C0378220#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [13, 14]}}
{"token": ["CDA", "I", "caused", "by", "mutations", "in", "the", "C1413248#ent", "<e1>", "encoding", "for", "C3273707#ent", "<e2>", "."], "h": {"id": "C1413248", "name": "C1413248#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273707", "name": "C3273707#ent", "pos": [11, 12]}}
{"token": ["Because", "the", "vascular", "NADPH", "oxidase", "an", "important", "C0038838#ent", "<e1>", "source", ",", "we", "studied", "the", "effect", "of", "C0068475#ent", "<e2>", "on", "endothelial", "function", "NADPH", "oxidase", "activity", "expression", "in", "the", "well-characterized", "model", "of", "angiotensin", "II-induced", "hypertension", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0068475", "name": "C0068475#ent", "pos": [16, 17]}}
{"token": ["However", ",", "there", "is", "no", "difference", "in", "the", "iron-sulfur", "cluster", "C2697645#ent", "<e1>", ")", "or", "the", "large", "subunit", "of", "cytochrome", "b", "C1419908#ent", "<e2>", ")", "between", "adult", "and", "L3", "isoforms", "complex", "II"], "h": {"id": "C2697645", "name": "C2697645#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419908", "name": "C1419908#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "inhibition", "of", "bladder", "carcinogenesis", "the", "extract", "was", "associated", "with", "induction", "of", "glutathione", "S-transferase", "NAD(P)H", ":", "quinone", "oxidoreductase", "1", "the", "bladder", ",", "C3540790#ent", "<e1>", "that", "are", "important", "C1579291#ent", "<e2>", "against", "oxidants", "and", "carcinogens", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1579291", "name": "C1579291#ent", "pos": [28, 29]}}
{"token": ["Expression", "of", "IL-1beta", ",", "IL-6", ",", "IL-8", ",", "and", "C1565860#ent", "<e1>", "mRNA", "was", "reduced", "by", "30", "microM", "PP1", ",", "an", "C1268567#ent", "<e2>", "and", "by", "25", "microM", "SB-203580", ",", "a", "p38", "MAPK", "inhibitor"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1268567", "name": "C1268567#ent", "pos": [20, 21]}}
{"token": ["This", "C0017337#ent", "<e1>", "is", "named", "C1418611#ent", "<e2>", "by", "the", "Human", "Nomenclature", "Committee"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418611", "name": "C1418611#ent", "pos": [5, 6]}}
{"token": ["C1176315#ent", "<e1>", ",", "in", "combination", "with", "other", "C0599685#ent", "<e2>", "is", "indicated", "for", "the", "treatment", "of", "patients", "with", "HIV", "infection", "particularly", "those", "who", "have", "not", "previously", "received", "antiretroviral", "therapy"], "h": {"id": "C1176315", "name": "C1176315#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0599685", "name": "C0599685#ent", "pos": [7, 8]}}
{"token": ["A", "model", "of", "C0018077#ent", "<e1>", "described", "that", "simulates", "C0012634#ent", "<e2>", "its", "progression", "from", "local", "to", "disseminated", "infection", "its", "milieu", "of", "mucin", "and", "hemoglobin", "."], "h": {"id": "C0018077", "name": "C0018077#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [8, 9]}}
{"token": ["Acyclovir", "(", "Zovirax", ")", "inhibited", "to", "some", "extent", "the", "spreading", "of", "the", "C0015230#ent", "<e1>", "and", "reduced", "the", "frequency", "of", "C0262509#ent", "<e2>"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0262509", "name": "C0262509#ent", "pos": [19, 20]}}
{"token": ["In", "situ", "hybridization", "cRNA", "probes", "C4082365#ent", "<e1>", "messenger", "RNA", "in", "identification", "of", "cell", "bodies", "transcribing", "the", "C1413376#ent", "<e2>"], "h": {"id": "C4082365", "name": "C4082365#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413376", "name": "C1413376#ent", "pos": [16, 17]}}
{"token": ["This", "case", "demonstrates", "that", "prophylactic", "use", "of", "C0016277#ent", "<e1>", "can", "cause", "C0001623#ent", "<e2>"], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001623", "name": "C0001623#ent", "pos": [11, 12]}}
{"token": ["Addition", "of", "IL-1beta", "activated", "nuclear", "factor", "kappaB", "C2986464#ent", "<e1>", ")", "in", "VSMCs", ",", "but", "C0037549#ent", "<e2>", "not", "affect", "IL-1beta-induced", "NF-kappaB", "activation"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037549", "name": "C0037549#ent", "pos": [14, 15]}}
{"token": ["These", "results", "demonstrate", "that", "C0252024#ent", "<e1>", ",", "but", "not", "C1426113#ent", "<e2>", ",", "is", "the", "downstream", "effector", "of", "C3G", "stimulate", "JNK", "."], "h": {"id": "C0252024", "name": "C0252024#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1426113", "name": "C1426113#ent", "pos": [9, 10]}}
{"token": ["C3541994#ent", "<e1>", "and", "familial", "pseudohyperkalemia", "thought", "to", "stem", "from", "the", "same", "C0079429#ent", "<e2>", ",", "mapping", "to", "16q23-q24", "."], "h": {"id": "C3541994", "name": "C3541994#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["We", "discuss", "the", "role", "of", "Leishmania", "FABP", "compare", "the", "immunological", "reactions", "with", "serum", "samples", "from", "other", "C0033741#ent", "<e1>", "as", "toxoplasma", "and", "Chagas", "as", "well", "as", "C0004623#ent", "<e2>", "as", "tuberculosis", "and", "syphilis", "."], "h": {"id": "C0033741", "name": "C0033741#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [25, 26]}}
{"token": ["C0014964#ent", "<e1>", "is", "commonly", "used", "for", "the", "treatment", "of", "tuberculous", "and", "C0026919#ent", "<e2>"], "h": {"id": "C0014964", "name": "C0014964#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0026919", "name": "C0026919#ent", "pos": [11, 12]}}
{"token": ["C1412325#ent", "<e1>", ",", "also", "referred", "to", "as", "the", "human", "bile", "acid", "binder", "3alpha-hydroxysteroid", "C1456345#ent", "<e2>", "is", "a", "multifunctional", "oxidoreductase", "able", "to", "stereoselectively", "reduce", "steroids", "as", "well", "as", "oxidize", "or", "reduce", "polyaromatic", "hydrocarbons"], "h": {"id": "C1412325", "name": "C1412325#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1456345", "name": "C1456345#ent", "pos": [13, 14]}}
{"token": ["Mitochondria", "isolated", "from", "sea", "urchin", "embryos", "in", "early", "development", "almost", "the", "same", "activities", "of", "C0010760#ent", "<e1>", "flavin-linked", "complex", "enzymes", ",", "which", "are", "estimated", "by", "C0010797#ent", "<e2>", "in", "those", "isolated", "from", "unfertilized", "eggs", "."], "h": {"id": "C0010760", "name": "C0010760#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010797", "name": "C0010797#ent", "pos": [24, 25]}}
{"token": ["The", "C0033640#ent", "<e1>", "of", "both", "Syk", "and", "C1428222#ent", "<e2>", "were", "found", "to", "parallel", "their", "reactivity", "in", "immunoblotting", "experiments", "with", "anti-phosphotyrosine", "antibodies", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1428222", "name": "C1428222#ent", "pos": [7, 8]}}
{"token": ["Previously", "we", "described", "an", "involvement", "of", "the", "C-type", "lectin", "receptor", "CD94", "and", "the", "neuronal", "adhesion", "molecule", "C1334863#ent", "<e1>", "in", "the", "interaction", "of", "natural", "killer", "NK", ")", "cells", "with", "C1415755#ent", "<e2>", "and", "Hsp70-peptide", "TKD", "."], "h": {"id": "C1334863", "name": "C1334863#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415755", "name": "C1415755#ent", "pos": [28, 29]}}
{"token": ["A", "phase", "I", "study", "determine", "safety", ",", "maximum", "tolerated", "dose", ",", "and", "biologic", "response", "multiple", "once-a-week", "administration", "of", "C0165032#ent", "<e1>", "an", "immune", "response", "modifier", "was", "conducted", "in", "12", "adults", "with", "early", "C3854222#ent", "<e2>", "HIV", ")", "infection", "."], "h": {"id": "C0165032", "name": "C0165032#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [31, 32]}}
{"token": ["Kearns-Sayre", "syndrome", "KSS", ")", "is", "a", "progressive", "neuromuscular", "disease", "by", "C0029089#ent", "<e1>", ",", "cardiac", "bloc", "branch", ",", "C0796072#ent", "<e2>", "associated", "with", "abnormal", "mitochondrial", "function"], "h": {"id": "C0029089", "name": "C0029089#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0796072", "name": "C0796072#ent", "pos": [17, 18]}}
{"token": ["One", "of", "the", "selection", "criteria", "this", "compound", "was", "its", "property", "of", "inhibiting", "more", "than", "one", "cancer", "relevant", "target", ",", "such", "as", "C1412097#ent", "<e1>", "wild-type", "and", "the", "multidrug", "resistant", "C4085851#ent", "<e2>", "mutant", "."], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [21, 22]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C4085851", "name": "C4085851#ent", "pos": [28, 29]}}
{"token": ["We", "investigated", "the", "anticalcification", "efficacy", "of", "oral", "potassium", "citrate", "the", "combined", "administration", "of", "this", "drug", "and", "C0126774#ent", "<e1>", "the", "magnesium-deficient", "rat", "developing", "C0403476#ent", "<e2>", "luminal", "microliths", "in", "the", "long", "term"], "h": {"id": "C0126774", "name": "C0126774#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0403476", "name": "C0403476#ent", "pos": [22, 23]}}
{"token": ["The", "tremor", "monitor", "demonstrated", "a", "dose", "response", "relationship", "to", "both", "soman-", "and", "C0030038#ent", "<e1>", "the", "antagonism", "of", "these", "tremors", "by", "various", "doses", "of", "C0004259#ent", "<e2>", "."], "h": {"id": "C0030038", "name": "C0030038#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [23, 24]}}
{"token": ["The", "most", "commonly", "described", "include", "skin", "rash", "arthritis", ",", "C0019559#ent", "<e1>", ",", "glomerulonephritis", ",", "polyarteritis", "nodosa", "and", "C0001197#ent", "<e2>", "."], "h": {"id": "C0019559", "name": "C0019559#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001197", "name": "C0001197#ent", "pos": [17, 18]}}
{"token": ["C1822614#ent", "<e1>", "activity", "was", "directly", "proportional", "to", "C2744672#ent", "<e2>", "which", "turned", "over", "very", "rapidly", "(", "t(1)/(2", ")", "of", "29", "min", ")", "and", "was", "degraded", "through", "the", "ubiquitin/proteasomal", "pathway"], "h": {"id": "C1822614", "name": "C1822614#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2744672", "name": "C2744672#ent", "pos": [7, 8]}}
{"token": ["It", "has", "become", "clear", "that", "this", "pathway", "regulates", "cellular", "proliferation", "movement", "and", "morphology", "in", "many", "different", "organs", "and", "that", "it", "is", "centrally", "involved", "in", "various", "C0012634#ent", "<e1>", "including", "cancer", "and", "C0007222#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [25, 26]}, "relation": "nichd_parent_of", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [30, 31]}}
{"token": ["With", "an", "aggressive", "approach", "diagnosis", "and", "therapy", ",", "the", "prognosis", "in", "patients", "with", "C0028242#ent", "<e1>", "appears", "to", "be", "dependent", "on", "their", "underlying", "C0027721#ent", "<e2>"], "h": {"id": "C0028242", "name": "C0028242#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [22, 23]}}
{"token": ["1", "Tetrahydroaminoacridine", "(", "THA", ")", "is", "an", "acetylcholinesterase", "(", "AChE", ")", "inhibitor", "which", "may", "have", "a", "greater", "therapeutic", "effect", "C0002395#ent", "<e1>", "ATD", ")", "than", "other", "C0242893#ent", "<e2>"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [25, 26]}}
{"token": ["Ten", "patients", "with", "dementia", "of", "the", "C0002395#ent", "<e1>", "serially", "administered", "three", "different", "intravenous", "doses", "the", "centrally", "active", "C0242893#ent", "<e2>", "scopolamine", "and", "placebo", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [17, 18]}}
{"token": ["An", "anatomical", "study", "the", "conducting", "pathways", "was", "carried", "out", "in", "a", "case", "of", "C0027126#ent", "<e1>", "by", "a", "complete", "C0004245#ent", "<e2>", "syncope", "."], "h": {"id": "C0027126", "name": "C0027126#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004245", "name": "C0004245#ent", "pos": [18, 19]}}
{"token": ["Perillyl", "alcohol", "rapidly", "C0025517#ent", "<e1>", "in", "the", "rat", ",", "as", "is", "C0064992#ent", "<e2>", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0064992", "name": "C0064992#ent", "pos": [11, 12]}}
{"token": ["Transfection", "efficiency", "of", "C1705526#ent", "<e1>", "was", "increased", "in", "vitro", "both", "C1428927#ent", "<e2>", "and", "SK-Hep1", "cells", "with", "increasing", "transferrin", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428927", "name": "C1428927#ent", "pos": [10, 11]}}
{"token": ["One", "further", "characterized", "cDNA", "clone", "C1835435#ent", "<e1>", ",", "consisting", "of", "723", "bp", ",", "surprisingly", "shows", "C1412821#ent", "<e2>", "ORF", ")", "in", "both", "orientations", "."], "h": {"id": "C1835435", "name": "C1835435#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [15, 16]}}
{"token": ["In", "the", "NC", "induction", "assay", "involving", "Chordin", "plus", "Wnt3a-injected", "animal", "caps", "C1537590#ent", "<e1>", "morpholino", "inhibited", "expression", "of", "Slug", ",", "C1420331#ent", "<e2>", "and", "Foxd3", ",", "but", "not", "of", "Pax3", "and", "Zic1", "."], "h": {"id": "C1537590", "name": "C1537590#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420331", "name": "C1420331#ent", "pos": [19, 20]}}
{"token": ["C1705207#ent", "<e1>", "has", "a", "compact", "structure", "a", "Zn(II)-binding", "site", "(", "C1825463#ent", "<e2>", ",", "His3", ",", "His11", ",", "and", "Asp76", ")", "at", "the", "N-terminus", "."], "h": {"id": "C1705207", "name": "C1705207#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1825463", "name": "C1825463#ent", "pos": [10, 11]}}
{"token": ["In", "plasma", ",", "L-tryptophan", "and", "C0022816#ent", "<e1>", "levels", "were", "reduced", "by", "pokeweed", "C0026249#ent", "<e2>", ",", "while", "the", "concentrations", "of", "L-kynurenine", ",", "3-hydroxykynurenine", "and", "quinolinic", "acid", "increased", "."], "h": {"id": "C0022816", "name": "C0022816#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [12, 13]}}
{"token": ["In", "a", "double-blind", ",", "randomized", "trial", "85", "adult", "patients", "with", "acute", "diarrhea", "more", "than", "three", "C0011991#ent", "<e1>", "day", ")", "received", "either", "500", "mg", "of", "C0008809#ent", "<e2>", "twice", "daily", "or", "placebo", "for", "five", "days", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [24, 25]}}
{"token": ["To", "determine", "whether", "C1705341#ent", "<e1>", "autophosphorylation", "mediated", "ET-1-dependent", "C0079471#ent", "<e2>", "activation", ",", "adenovirus-mediated", "transfer", "was", "employed", "to", "express", "a", "dominant-negative", "form", "of", "C1705341#ent", "<e1>", "(", "CRNK", ")", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [8, 9]}}
{"token": ["Accordingly", ",", "SP600125", ",", "the", "inhibitor", "of", "JNK", ",", "and", "wortmannin", ",", "the", "inhibitor", "of", "phosphatidylinositol", "3-kinase", "which", "is", "the", "upstream", "activator", "C1705341#ent", "<e1>", ",", "inhibited", "the", "increase", "in", "the", "cellular", "content", "C0079471#ent", "<e2>", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [32, 33]}}
{"token": ["This", "process", "involves", "activation", "of", "JNK", ",", "which", "enhances", "the", "synthesis", "of", "C0079471#ent", "<e1>", ",", "combined", "with", "the", "activation", "of", "C1705341#ent", "<e2>", ",", "which", "inhibits", "C0079471#ent", "<e1>", "degradation", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [12, 13]}}
{"token": ["Although", "sickle", "cell", "disease", "C1419846#ent", "<e1>", ")", "and", "systemic", "lupus", "erythematosus", "SLE", ")", "are", "two", "distinct", "C1561643#ent", "<e2>", "many", "clinical", "features", "are", "common", "to", "both", "conditions", "."], "h": {"id": "C1419846", "name": "C1419846#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [16, 17]}}
{"token": ["We", "found", "that", "treatment", "of", "cortical", "neurons", "in", "culture", "with", "C1705543#ent", "<e1>", "produces", "a", "marked", "increase", "in", "C1334905#ent", "<e2>", "precedes", "apoptotic", "neurotoxicity", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334905", "name": "C1334905#ent", "pos": [17, 18]}}
{"token": ["Renal", "lesions", "the", "expression", "of", "TGF-beta1", ",", "type", "I", "collagen", "C1335828#ent", "<e1>", ",", "Ski", ",", "and", "C4049869#ent", "<e2>", "were", "examined", "by", "immunohistochemistry", ",", "Western", "blot", "and/or", "real-time", "reverse", "transcriptase-polymerase", "chain", "reaction"], "h": {"id": "C1335828", "name": "C1335828#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4049869", "name": "C4049869#ent", "pos": [16, 17]}}
{"token": ["HIV-related", "conditions", "in", "which", "thalidomide", "may", "be", "useful", "include", "C0038363#ent", "<e1>", "wasting", ",", "diarrhea", ",", "and", "C0033771#ent", "<e2>"], "h": {"id": "C0038363", "name": "C0038363#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033771", "name": "C0033771#ent", "pos": [16, 17]}}
{"token": ["Staining", "was", "not", "observed", "in", "seven", "liver", "cell", "adenomas", "10", "cases", "of", "C0700636#ent", "<e1>", "or", "eight", "cases", "of", "C1623038#ent", "<e2>", "."], "h": {"id": "C0700636", "name": "C0700636#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [18, 19]}}
{"token": ["Seropositivity", "was", "found", "in", "100", "%", "of", "secondary", "and", "early", "latent", "C0039128#ent", "<e1>", "patients", ",", "75", "%", "of", "C2931317#ent", "<e2>", "patients", ",", "and", "80", "%", "of", "late", "latent", "syphilis", "patients", "."], "h": {"id": "C0039128", "name": "C0039128#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C2931317", "name": "C2931317#ent", "pos": [18, 19]}}
{"token": ["MICs", "of", "IPM", ",", "C4084869#ent", "<e1>", ",", "MEPM", ",", "CAZ", "and", "C3541431#ent", "<e2>", "were", "2", "micrograms/ml", ",", "64", "micrograms/ml", ",", "1", "microgram/ml", ",", "1", "microgram/ml", "and", "2", "micrograms/ml", ",", "respectively", "."], "h": {"id": "C4084869", "name": "C4084869#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541431", "name": "C3541431#ent", "pos": [11, 12]}}
{"token": ["The", "C1332101#ent", "<e1>", "locus", "is", "on", "the", "inversion-free", "X", "chromosome", "the", "chromosomal", "locus", "the", "autosomal", "C0207890#ent", "<e2>", "is", "unknown", ",", "and", "could", "involve", "inversion", "polymorphism"], "h": {"id": "C1332101", "name": "C1332101#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0207890", "name": "C0207890#ent", "pos": [15, 16]}}
{"token": ["Striated", "adrenal", "cells", "in", "the", "zona", "reticularis", "C0015644#ent", "<e1>", "constitute", "the", "initial", "adrenolytic", "lesion", "in", "patients", "with", "C0162309#ent", "<e2>", "(", "ALD", ")", "."], "h": {"id": "C0015644", "name": "C0015644#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162309", "name": "C0162309#ent", "pos": [17, 18]}}
{"token": ["w/v", ")", "Triton", "X-100", "butanol", "or", "C0030346#ent", "<e1>", ",", "whereas", "Tris", "and", "C3537218#ent", "<e2>", "extracted", "only", "the", "lower", "molecular", "weight", "proteins", "possible", "derived", "from", "the", "core", "filaments"], "h": {"id": "C0030346", "name": "C0030346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3537218", "name": "C3537218#ent", "pos": [12, 13]}}
{"token": ["Classical", "C0162757#ent", "<e1>", "methysergide", ",", "metergoline", ",", "C0008788#ent", "<e2>", "and", "methiothepin", ")", "were", "either", "without", "effect", "or", "facilitated", "the", "response", "and", "the", "5-HT2", "antagonist", "ritanserin", "was", "also", "without", "effect", "."], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008788", "name": "C0008788#ent", "pos": [7, 8]}}
{"token": ["C0162757#ent", "<e1>", "methergoline", ",", "methysergide", ",", "and", "C0008788#ent", "<e2>", ")", "did", "not", "potentiate", "myoclonus", "induced", "by", "p", ",", "p'-DDT", "."], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008788", "name": "C0008788#ent", "pos": [7, 8]}}
{"token": ["The", "good", "effect", "of", "C0017887#ent", "<e1>", "is", "worth", "a", "control", "in", "patients", "with", "common", "C0030305#ent", "<e2>"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [14, 15]}}
{"token": ["After", "the", "occurrence", "of", "C0036572#ent", "<e1>", "induced", "by", "enoxacin", "with", "fenbufen", ",", "administration", "of", "the", "C0242909#ent", "<e2>", "MK-801", "at", "1", "mg/kg", ",", "i.v", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242909", "name": "C0242909#ent", "pos": [15, 16]}}
{"token": ["The", "role", "of", "nitric", "oxide", "NO", ")", "in", "the", "genesis", "of", "motor", "and", "C0036572#ent", "<e1>", "by", "administration", "of", "C0242909#ent", "<e2>", "the", "deep", "prepiriform", "cortex", "DPC", ")", "has", "been", "evaluated", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242909", "name": "C0242909#ent", "pos": [18, 19]}}
{"token": ["The", "Escherichia", "coli", "degradosome", "is", "a", "multienzyme", "complex", "four", "major", "protein", "components", "the", "C0014241#ent", "<e1>", "the", "exoribonuclease", "PNPase", "the", "RNA", "helicase", "and", "C0031691#ent", "<e2>", "."], "h": {"id": "C0014241", "name": "C0014241#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031691", "name": "C0031691#ent", "pos": [22, 23]}}
{"token": ["These", "results", "indicate", "that", "activation", "of", "AMPK", "stimulates", "C2678065#ent", "<e1>", "degradation", "through", "the", "expression", "of", "atrogin-1/MAFbx", "and", "C4049869#ent", "<e2>", "by", "increasing", "FOXO", "transcription", "factors", "in", "skeletal", "muscles"], "h": {"id": "C2678065", "name": "C2678065#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4049869", "name": "C4049869#ent", "pos": [17, 18]}}
{"token": ["The", "uptake", "of", "C0005270#ent", "<e1>", "(", "EC", "3.2.1.30", "in", "nonparenchymal", "liver", "cells", "i.e.", "C0669365#ent", "<e2>", "and", "Kupffer's", "cells", "and", "peritoneal", "macrophages", "been", "determined", "by", "an", "enzymatic", "assay"], "h": {"id": "C0005270", "name": "C0005270#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [13, 14]}}
{"token": ["These", "data", ",", "obtained", "using", "a", "stimulus", "control", "model", "of", "the", "hallucinogenic", "effects", "of", "C1535939#ent", "<e1>", ",", "fail", "to", "support", "the", "hypothesis", "that", "LSD", "and", "C3539821#ent", "<e2>", "completely", "antagonize", "stimulus", "control", "C1535939#ent", "<e1>", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3539821", "name": "C3539821#ent", "pos": [25, 26]}}
{"token": ["Increased", "platelet", "aggregability", "found", "at", "the", "time", "when", "the", "complicated", "C0154723#ent", "<e1>", "attacks", "were", "frequent", "and", ",", "therefore", ",", "treatment", "with", "C0012582#ent", "<e2>", "and", "aspirin", "was", "given", "."], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012582", "name": "C0012582#ent", "pos": [21, 22]}}
{"token": ["Matrix", "metalloproteinases", "C0919336#ent", "<e1>", ")", "are", "a", "family", "of", "C3540759#ent", "<e2>", "mediate", "the", "degradation", "of", "extracellular", "matrix", "macromolecules", ",", "including", "interstitial", "and", "basement", "membrane", "collagens", "fibronectin", ",", "laminin", ",", "and", "proteoglycan", "core", "protein"], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540759", "name": "C3540759#ent", "pos": [9, 10]}}
{"token": ["The", "evaluation", "of", "insulin", "response", "Dex", "may", "thus", "allow", "differentiation", "of", "the", "subset", "of", "C1540295#ent", "<e1>", "that", "run", "an", "increased", "risk", "of", "C0011854#ent", "<e2>"], "h": {"id": "C1540295", "name": "C1540295#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [22, 23]}}
{"token": ["It", "is", "known", "that", "inhibition", "of", "C1565860#ent", "<e1>", "(", "COX", ")", "impairs", "the", "renal", "actions", "of", "C0354100#ent", "<e2>"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0354100", "name": "C0354100#ent", "pos": [16, 17]}}
{"token": ["In", "the", "present", "study", ",", "the", "possible", "involvement", "of", "the", "C1514550#ent", "<e1>", "PKA", ")", "in", "DA", "D1-stimulated", "C3539616#ent", "<e2>", "release", "was", "also", "examined", "."], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [17, 18]}}
{"token": ["However", ",", "doses", "of", "vitamin", "D", "sterols", "to", "suppress", "parathyroid", "hormone", "C1419072#ent", "<e1>", ")", "secretion", "often", "promote", "hypercalcaemia", "and", "C0085681#ent", "<e2>", "."], "h": {"id": "C1419072", "name": "C1419072#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085681", "name": "C0085681#ent", "pos": [19, 20]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "necropsy", "samples", "of", "renal", "cortex", "normal", "and", "C1366550#ent", "<e1>", "dogs", "for", "C1723257#ent", "<e2>", "and", "MMP-7", "as", "they", "have", "the", "potential", "to", "activate", "MMP-2", "and", "MMP-9", "."], "h": {"id": "C1366550", "name": "C1366550#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1723257", "name": "C1723257#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "Col11a1", "cause", "Marshall", "and", "C2020284#ent", "<e1>", "both", "of", "which", "are", "characterized", "by", "craniofacial", "abnormalities", "C0027092#ent", "<e2>", "and", "hearing", "deficiencies", "."], "h": {"id": "C2020284", "name": "C2020284#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0027092", "name": "C0027092#ent", "pos": [16, 17]}}
{"token": ["Despite", "early", "treatment", "C0048504#ent", "<e1>", "and", "without", "the", "development", "of", "acidosis", "or", "C0035078#ent", "<e2>", "the", "patient", "required", "HD", "for", "hyperosmolality", "and", "subsequent", "electrolyte", "imbalances", "."], "h": {"id": "C0048504", "name": "C0048504#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [12, 13]}}
{"token": ["A", "mechanical", "dissociation", "technique", "was", "used", "to", "C1875400#ent", "<e1>", "neurones", "from", "superior", "cervical", "ganglia", "C0012694#ent", "<e2>", ")", "of", "rats", "aged", "between", "gestational", "day", "and", "postnatal", "day", "21", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [14, 15]}}
{"token": ["The", "method", "is", "applicable", "over", "the", "range", "1", "-", "12", "mug", "ml", "for", "isoxsuprine", "hydrochloride", "C0028735#ent", "<e1>", "1", "-", "8", "mug", "ml", "for", "C0543495#ent", "<e2>"], "h": {"id": "C0028735", "name": "C0028735#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [23, 24]}}
{"token": ["Gene", "expression", "studies", "the", "human", "C1705281#ent", "<e1>", "gene", "promoter", "to", "a", "C1334435#ent", "<e2>", "that", "I3C", "inhibits", "the", "transcription", "of", "the", "MUC1", "gene"], "h": {"id": "C1705281", "name": "C1705281#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334435", "name": "C1334435#ent", "pos": [11, 12]}}
{"token": ["Mannose", "also", "inhibited", "the", "expression", "of", "C0671550#ent", "<e1>", "mRNA", "induced", "by", "ConA.", "Cytochalasin", "B", "C0009262#ent", "<e2>", "had", "no", "effect", "the", "ConA", "induction", "of", "proMMP-2", "activation", "."], "h": {"id": "C0671550", "name": "C0671550#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [14, 15]}}
{"token": ["Arborisation", "also", "depends", "on", "matrix", "components", ",", "including", "proteoglycans", ",", "integrins", "and", "their", "ligands", ",", "and", "C1334706#ent", "<e1>", ",", "such", "as", "C0165519#ent", "<e2>", "that", "are", "involved", "in", "matrix", "remodelling", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0165519", "name": "C0165519#ent", "pos": [21, 22]}}
{"token": ["Sulfasalazine", "and", "its", "C0127615#ent", "<e1>", "among", "the", "most", "effective", "agents", "for", "treating", "inflammatory", "bowel", "disease", "C0038013#ent", "<e2>"], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [15, 16]}}
{"token": ["Unlike", "apoptotic", "blebbing", ",", "C1419230#ent", "<e1>", "R386A-induced", "blebbing", "was", "not", "inhibited", "by", "the", "ROCK", "inhibitor", "C0667301#ent", "<e2>", ",", "suggesting", "that", "C1419230#ent", "<e1>", "regulates", "cortical", "activity", "cytokinesis", "through", "a", "novel", "signaling", "pathway"], "h": {"id": "C1419230", "name": "C1419230#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0667301", "name": "C0667301#ent", "pos": [15, 16]}}
{"token": ["The", "class", "II", "isoforms", "of", "the", "two", "C0020289#ent", "<e1>", "exhibited", "no", "C0003308#ent", "<e2>"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [11, 12]}}
{"token": ["To", "this", "end", ",", "elutriation-purified", "human", "monocytes", "were", "treated", "in", "vitro", "purified", "recombinant", "human", "C1524095#ent", "<e1>", "and", "GM-CSF", ",", "and", "C3887675#ent", "<e2>", "and", "PAI-1", "antigen", "mRNA", "levels", "measured", "by", "specific", "enzyme-linked", "immunosorbent", "assays", "Northern", "blot", "respectively", "."], "h": {"id": "C1524095", "name": "C1524095#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3887675", "name": "C3887675#ent", "pos": [20, 21]}}
{"token": ["C1538659#ent", "<e1>", "is", "a", "fatty", "acid-", "C0380931#ent", "<e2>", "which", "has", "a", "catalytic", "domain", "homologous", "to", "that", "of", "protein", "kinase", "C", "PKC", ")", "."], "h": {"id": "C1538659", "name": "C1538659#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0380931", "name": "C0380931#ent", "pos": [6, 7]}}
{"token": ["In", "this", "study", "we", "have", "compared", "the", "effects", "of", "ketoconazole", "and", "C0016277#ent", "<e1>", ",", "a", "novel", "triazole", "antifungal", "agent", "on", "C1415739#ent", "<e2>", "production", "in", "rat", "ovaries", "in", "vitro"], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415739", "name": "C1415739#ent", "pos": [20, 21]}}
{"token": ["The", "effect", "of", "diltiazem", "on", "atrioventricular", "conduction", "studied", "in", "C0030883#ent", "<e1>", "anesthetized", "dogs", ",", "conscious", "dogs", "and", "C0004259#ent", "<e2>", "pretreated", "conscious", "dogs"], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [17, 18]}}
{"token": ["Diuretic", "resistance", "C0016860#ent", "<e1>", "in", "the", "C0027726#ent", "<e2>", "NS", ")", "may", "result", "from", "binding", "of", "drug", "to", "filtered", "albumin", "within", "the", "renal", "tubule"], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [6, 7]}}
{"token": ["Herpes", "simplex", "virus", "HSV", ")", "types", "1", "and", "2", "are", "highly", "successful", "human", "pathogens", "that", "can", "elicit", "blinding", "herpetic", "keratoconjunctivitis", "fatal", "sporadic", "encephalitis", ",", "C0025297#ent", "<e1>", "and", "increase", "the", "risk", "of", "acquiring", "additional", "C0036916#ent", "<e2>"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [33, 34]}}
{"token": ["This", "article", "discusses", "C0040947#ent", "<e1>", ",", "hookworm", "infection", "trichostrongyliasis", ",", "ascariasis", ",", "C0040954#ent", "<e2>", "(", "whipworm", "infection", ",", "and", "enterobiasis", "(", "pinworm", "infection", "."], "h": {"id": "C0040947", "name": "C0040947#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040954", "name": "C0040954#ent", "pos": [12, 13]}}
{"token": ["Twelve", "phenolic", "compounds", "identified", "in", "calli", ":", "gallic", "acid", "3-O-caffeoylquinic", "acid", "5-O-caffeoylquinic", "acid", "caffeic", "acid", "rosmarinic", "acid", "hesperetin", ",", "epirosmanol", ",", "C0062736#ent", "<e1>", ",", "genkwanin", ",", "carnosol", ",", "C0074007#ent", "<e2>", "and", "methyl", "carnosate"], "h": {"id": "C0062736", "name": "C0062736#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0074007", "name": "C0074007#ent", "pos": [28, 29]}}
{"token": ["Finally", ",", "we", "provide", "genetic", "evidence", "the", "essential", "role", "of", "C1861421#ent", "<e1>", "in", "the", "inducible", "processing", "of", "C1540205#ent", "<e2>", "."], "h": {"id": "C1861421", "name": "C1861421#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1540205", "name": "C1540205#ent", "pos": [17, 18]}}
{"token": ["Overall", ",", "the", "results", "indicate", "that", "African", "Americans", "knowledgeable", "about", "AIDS", ",", "but", "there", "appears", "to", "be", "a", "C2984553#ent", "<e1>", "between", "knowledge", "and", "C1367457#ent", "<e2>", "sexual", "behaviors"], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1367457", "name": "C1367457#ent", "pos": [23, 24]}}
{"token": ["Unfortunately", "C0238115#ent", "<e1>", "due", "to", "subsequently", "diagnosed", "C3489393#ent", "<e2>"], "h": {"id": "C0238115", "name": "C0238115#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3489393", "name": "C3489393#ent", "pos": [7, 8]}}
{"token": ["The", "C0238115#ent", "<e1>", "most", "probably", "in", "the", "absence", "of", "C3489393#ent", "<e2>", "in", "2", "of", "3", "previously", "reported", "cases", "wherein", "a", "hernia", "was", "present", ",", "a", "combined", "gastroesophageal", "rupture", "."], "h": {"id": "C0238115", "name": "C0238115#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3489393", "name": "C3489393#ent", "pos": [9, 10]}}
{"token": ["We", "present", "the", "case", "of", "a", "75-year-old", "man", "who", "presented", "in", "our", "emergency", "room", "a", "large", "C0149781#ent", "<e1>", "developed", "severe", "C0264490#ent", "<e2>", "circulatory", "collapse", "drainage", "via", "a", "chest", "tube"], "h": {"id": "C0149781", "name": "C0149781#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [20, 21]}}
{"token": ["The", "picture", "has", "been", "confused", "by", "the", "presence", "of", "many", "C0033799#ent", "<e1>", "of", "both", "HSP60", "and", "C1415790#ent", "<e2>", "and", "the", "long", "surviving", "assumption", "that", "the", "HSP60", "gene", "intron-less", "."], "h": {"id": "C0033799", "name": "C0033799#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415790", "name": "C1415790#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "to", "C1704998#ent", "<e1>", ",", "we", "found", "DNA", "repair", "proteins", "C1419239#ent", "<e2>", ",", "Mre11", ",", "PARP1", "(", "poly(ADP-ribose)", "polymerase", ",", "and", "Ku86/Ku70", "to", "be", "in", "this", "telomeric", "complex"], "h": {"id": "C1704998", "name": "C1704998#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419239", "name": "C1419239#ent", "pos": [11, 12]}}
{"token": ["A", "good", "correlation", "is", "present", "between", "the", "percentage", "of", "sarcoid", "C3813124#ent", "<e1>", "expressing", "CD86", "and", "CD40", "or", "CD86", "and", "C3889999#ent", "<e2>", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3889999", "name": "C3889999#ent", "pos": [19, 20]}}
{"token": ["A", "similar", "effect", "was", "noted", "with", "sodium", "nitroprusside", "C1826346#ent", "<e1>", ";", "10", "-", "100", "nM", ")", "and", "C0917964#ent", "<e2>", "(", "1", "microM", ")", "but", "not", "with", "prazosin", "(", "1", "nM", ")", "."], "h": {"id": "C1826346", "name": "C1826346#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [17, 18]}}
{"token": ["To", "study", "the", "effect", "of", "Chinese", "herbal", "medicine", "CHM", ")", "based", "on", "Syndrome", "Differentiation", "on", "C0032805#ent", "<e1>", "complications", "in", "patients", "with", "C0018799#ent", "<e2>", "."], "h": {"id": "C0032805", "name": "C0032805#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [21, 22]}}
{"token": ["Clinical", "trials", "patients", "with", "cancer", "of", "the", "C0771711#ent", "<e1>", "used", "a", "novel", "study", "end", "point", "called", "clinical", "benefits", "response", "C3889664#ent", "<e2>", ")", "to", "measure", "gemcitabine's", "effect", "on", "disease-related", "symptoms", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889664", "name": "C3889664#ent", "pos": [19, 20]}}
{"token": ["C0271370#ent", "<e1>", "restrictions", "of", "elevation", "and", "adduction", ",", "and", "C0004259#ent", "<e2>", "was", "observed", "in", "the", "left", "eye"], "h": {"id": "C0271370", "name": "C0271370#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [9, 10]}}
{"token": ["These", "vesicles", "can", "be", "fused", "with", "the", "plasma", "membrane", "cells", "from", "homologous", "and", "heterologous", "B16", "sublines", "using", "C0032483#ent", "<e1>", "PEG", ")", "and", "phytohemagglutinin", "(", "C0030779#ent", "<e2>", ")", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [24, 25]}}
{"token": ["C2826078#ent", "<e1>", "catalyzes", "thrombin", "formation", "the", "ordered", "cleavage", "of", "two", "C0030956#ent", "<e2>", "prothrombin", "."], "h": {"id": "C2826078", "name": "C2826078#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}}
{"token": ["Titration", "of", "plasma-derived", "prothrombin", "activation", "by", "C2826078#ent", "<e1>", ",", "with", "increasing", "concentrations", "of", "C0030956#ent", "<e2>", ",", "resulted", "in", "complete", "inhibition", "of", "the", "meizo", "pathway", "."], "h": {"id": "C2826078", "name": "C2826078#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [13, 14]}}
{"token": ["In", "four", "samples", "an", "activated", "C0027260#ent", "<e1>", "and", "in", "two", "samples", "an", "activated", "C0079473#ent", "<e2>", "detected", "in", "transfectants", "."], "h": {"id": "C0027260", "name": "C0027260#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079473", "name": "C0079473#ent", "pos": [13, 14]}}
{"token": ["The", "effects", "of", "C0003374#ent", "<e1>", "mefloquine", "and", "C0120726#ent", "<e2>", "and", "of", "their", "major", "metabolites", "on", "metoprolol", "metabolism", "by", "rat", "liver", "microsomes", "have", "been", "investigated", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0120726", "name": "C0120726#ent", "pos": [7, 8]}}
{"token": ["There", "were", "no", "correlations", "of", "atovaquone", "with", "the", "eight", "other", "C0003374#ent", "<e1>", "among", "African", "strains", "but", "significant", "correlations", ",", "except", "for", "C0120726#ent", "<e2>", ",", "were", "observed", "among", "Asian", "strains", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [10, 11]}, "relation": "therapeutic_class_of", "t": {"id": "C0120726", "name": "C0120726#ent", "pos": [21, 22]}}
{"token": ["A", "rapid", "amplification", "of", "cDNA", "ends", "method", ",", "using", "degenerate", "oligonucleotides", "upon", "the", "N-terminal", "amino", "acid", "sequence", "human", "C1432808#ent", "<e1>", "C1336670#ent", "<e2>", ",", "allowed", "a", "novel", "cDNA", "encoding", "C1336670#ent", "<e2>", "be", "constructed", "from", "thyroid", "gland", "RNA"], "h": {"id": "C1432808", "name": "C1432808#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1336670", "name": "C1336670#ent", "pos": [20, 21]}}
{"token": ["Murine", "monoclonal", "C1432808#ent", "<e1>", "DNase", "II", "antibodies", "were", "obtained", "from", "BALB/c", "mice", "immunized", "with", "C1336670#ent", "<e2>", "purified", "from", "human", "liver", "."], "h": {"id": "C1432808", "name": "C1432808#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1336670", "name": "C1336670#ent", "pos": [14, 15]}}
{"token": ["Tyrphostins", "previously", "characterized", "for", "their", "interactions", "with", "epithelial", "growth", "factor", "EGF", ")", "C3537377#ent", "<e1>", "tested", "for", "their", "potential", "effects", "on", "C1334089#ent", "<e2>", "growth-promoting", "activity"], "h": {"id": "C3537377", "name": "C3537377#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [20, 21]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "tyrosine", "kinase", "receptors", "C1333340#ent", "<e2>", "and", "EphB3", "are", "beta-catenin", "and", "Tcf4", "target", "C0017337#ent", "<e1>", "in", "colorectal", "cancer", "CRC", ")", "and", "in", "normal", "intestinal", "cells"], "h": {"id": "C1333340", "name": "C1333340#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}}
{"token": ["Diffuse", "scleroderma", "the", "most", "severe", "form", "of", "progressive", "C1290138#ent", "<e1>", "is", "associated", "with", "production", "of", "autoantibodies", "specific", "for", "C0036421#ent", "<e2>", "topoisomerase", "I", "."], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [18, 19]}}
{"token": ["Upstream", "signaling", "requirements", "of", "retinoic", "acid", "C1706891#ent", "<e1>", "expression", "and", "downstream", "signaling", "of", "C1706891#ent", "<e1>", "over-expression", "in", "a", "human", "myeloid", "leukemia", "cell", "line", "that", "C0752312#ent", "<e1>", "MAPK", ")", "signaling", "complexes", "involved", "in", "both", "avenues", "."], "h": {"id": "C1706891", "name": "C1706891#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [24, 25]}}
{"token": ["The", "test", "substances", "derivatives", "of", "nitroimidazole", "(", "metronidazole", ")", ",", "C0028155#ent", "<e1>", "(", "SQ", "18", "506", ")", "and", "C0031434#ent", "<e2>", "(", "amoscanate", ")", "."], "h": {"id": "C0028155", "name": "C0028155#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031434", "name": "C0031434#ent", "pos": [18, 19]}}
{"token": ["A", "650-kb", "YAC", "containing", "the", "loci", "C0025627#ent", "<e1>", ",", "MAOB", ",", "and", "C0093999#ent", "<e2>", "has", "been", "used", "as", "the", "starting", "point", "for", "a", "bidirectional", "chromosomal", "walk", "."], "h": {"id": "C0025627", "name": "C0025627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0093999", "name": "C0093999#ent", "pos": [12, 13]}}
{"token": ["We", "then", "transduced", "human", "and", "murine", "C0242957#ent", "<e1>", "two", "mutually", "noncross-reactive", "fibrosarcoma", "lines", "of", "BALB/c", "origin", "CMS7", "and", "C4225377#ent", "<e2>", "."], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4225377", "name": "C4225377#ent", "pos": [18, 19]}}
{"token": ["Expression", "of", "the", "hormone-regulated", "genes", ",", "pS2", ",", "C1418587#ent", "<e1>", "PIP", ")", "and", "C3658233#ent", "<e2>", "FAS", ")", ",", "was", "investigated", "by", "Northern", "blotting", "primary", "breast", "carcinoma", "metastatic", "breast", "cancer", "axillary", "lymph", "nodes", "in", "uninvolved", "breast", "tissue", "mastectomies", "and", "in", "normal", "lymph", "nodes"], "h": {"id": "C1418587", "name": "C1418587#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3658233", "name": "C3658233#ent", "pos": [13, 14]}}
{"token": ["We", "evaluated", "whether", "the", "action", "of", "C0014027#ent", "<e1>", "on", "the", "tubulointerstitial", "lesions", "by", "C0020500#ent", "<e2>", "persisted", "for", "a", "long", "period", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [13, 14]}}
{"token": ["In", "previous", "studies", "we", "demonstrated", "that", "C0014027#ent", "<e1>", "was", "effective", "against", "the", "progression", "of", "tubulointerstitial", "lesions", "a", "4-week", "C0020500#ent", "<e2>", "rat", "model", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [18, 19]}}
{"token": ["We", "have", "determined", "the", "three-dimensional", "structure", "the", "C1520223#ent", "<e1>", "human", "deformed", "epidermal", "autoregulatory", "factor-1", "(", "C1419034#ent", "<e2>", ")", "."], "h": {"id": "C1520223", "name": "C1520223#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419034", "name": "C1419034#ent", "pos": [15, 16]}}
{"token": ["The", "levels", "of", "C1333522#ent", "<e1>", "on", "the", "prostasomes", "were", "also", "decreased", "but", "the", "C1333522#ent", "<e1>", "activity", "in", "the", "conditioned", "medium", "the", "simvastatin-treated", "C1704969#ent", "<e1>", "increased", "due", "to", "apoptosis-dependent", "release", "of", "prostasomes", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704969", "name": "C1704969#ent", "pos": [22, 23]}}
{"token": ["In", "marked", "contrast", ",", "the", "mutant", "enzyme", "displayed", "wild", "type", "sensitivity", "to", "C1271552#ent", "<e1>", "and", "was", "severalfold", "hypersensitive", "to", "C0013901#ent", "<e2>", "."], "h": {"id": "C1271552", "name": "C1271552#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013901", "name": "C0013901#ent", "pos": [19, 20]}}
{"token": ["These", "results", "indicate", "that", "there", "is", "some", "cobalamin", "requirement", "for", "the", "utilization", "of", "serum", "methyltetrahydrofolate", "verify", "one", "prediction", "of", "the", "\"", "C2939773#ent", "<e1>", "explanation", "for", "the", "C0002888#ent", "<e2>", "of", "B(12", ")", "deficiency", "."], "h": {"id": "C2939773", "name": "C2939773#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0002888", "name": "C0002888#ent", "pos": [26, 27]}}
{"token": ["Many", "C0220918#ent", "<e1>", ":", "C0027280#ent", "<e2>", "bacteria", "and", "mitochondria", ",", "i.e.", "C0220918#ent", "<e1>", ":", "quinone", "reductases", "fumarate", "reductases", "contain", "in", "the", "membrane", "anchor", "cytochrome", "b", "structure", "and", "function", "is", "poorly", "understood", "."], "h": {"id": "C0027280", "name": "C0027280#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0220918", "name": "C0220918#ent", "pos": [1, 2]}}
{"token": ["Furthermore", ",", "C1418450#ent", "<e1>", "inhibited", "Ang-II-induced", "up-regulation", "of", "mRNA", "levels", "of", "p22phox", ",", "C1417771#ent", "<e2>", ",", "and", "gp91phox/Nox2", ",", "which", "are", "membrane", "components", "NADPH", "oxidase", "and", "its", "enzymatic", "activity", "HUVEC", "."], "h": {"id": "C1418450", "name": "C1418450#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417771", "name": "C1417771#ent", "pos": [13, 14]}}
{"token": ["Anti-peptide", "antibodies", "raised", "against", "synthetic", "peptides", "from", "the", "sequences", "of", "human", "C0699919#ent", "<e1>", "L", ",", "porcine", "cathepsin", "D", "C0172537#ent", "<e2>"], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [18, 19]}}
{"token": ["We", "experienced", "that", "C0020676#ent", "<e1>", "severe", "bradycardia", "and", "2:1", "C0004245#ent", "<e2>", "and", "that", "thyroxine", "supplementation", "completely", "improved", "these", "conditions", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004245", "name": "C0004245#ent", "pos": [9, 10]}}
{"token": ["Glutathione", "S-transferases", "GST", ")", "are", "multifunctional", "proteins", "encoded", "by", "a", "large", "C1517488#ent", "<e1>", "divided", "on", "the", "basis", "of", "sequence", "identity", "C1333690#ent", "<e2>", ",", "tau", ",", "theta", ",", "zeta", "and", "lambda", "classes"], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [20, 21]}}
{"token": ["C3274667#ent", "<e1>", ",", "which", "fuses", "the", "DNA-binding", "domain", "C1335654#ent", "<e2>", "to", "most", "of", "FOG2", ",", "represses", "the", "transcriptional", "activity", "both", "CBF", "and", "GATA1", "."], "h": {"id": "C3274667", "name": "C3274667#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [8, 9]}}
{"token": ["C1335865#ent", "<e1>", "is", "a", "member", "of", "the", "C1414083#ent", "<e2>", "associated", "protein", "complex", "skeletal", "and", "extraocular", "muscle", "maps", "to", "human", "chromosome", "12p11.2", "."], "h": {"id": "C1335865", "name": "C1335865#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", ",", "a", "novel", "proteomic", "approach", "used", "to", "identify", "specific", "C0086376#ent", "<e1>", "oxidized", "after", "C0009079#ent", "<e2>", "treatment", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [16, 17]}}
{"token": ["Chymotrypsinogen", "and", "C0960371#ent", "<e1>", "pancreatic", "contents", "were", "greatly", "augmented", ";", "lipase", "and", "C0009304#ent", "<e2>", "contents", "were", "not", "affected", ",", "whereas", "the", "amylase", "content", "tended", "to", "decrease", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009304", "name": "C0009304#ent", "pos": [12, 13]}}
{"token": ["In", "the", "most", "severe", "form", "(", "type", "1", ")", ",", "recurrent", "kidney", "stones", "progressive", "C0027709#ent", "<e1>", "lead", "to", "the", "loss", "of", "kidney", "function", "accompanied", "by", "C0268165#ent", "<e2>", "and", "often", "requires", "dialysis", "and/or", "transplantation", "."], "h": {"id": "C0027709", "name": "C0027709#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0268165", "name": "C0268165#ent", "pos": [25, 26]}}
{"token": ["In", "other", "organs", ",", "C0008677#ent", "<e1>", "and", "scattered", "foci", "of", "immature", "C0268731#ent", "<e2>", "in", "renal", "cortex", "noted", "."], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [11, 12]}}
{"token": ["C0030759#ent", "<e1>", "were", "also", "injected", "with", "two", "other", "organic", "acids", "C0600203#ent", "<e2>", "DCAA", ")", "and", "kainic", "acid", "KA", ")", "."], "h": {"id": "C0030759", "name": "C0030759#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0600203", "name": "C0600203#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "C0010583#ent", "<e1>", "inhibits", "but", "does", "not", "abolish", "C0156259#ent", "<e2>", "uninephrectomy", "in", "the", "young", "rat", "and", "this", "inhibition", "is", "mediated", "primarily", "through", "the", "reduced", "food", "intake", "by", "the", "drug", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0156259", "name": "C0156259#ent", "pos": [10, 11]}}
{"token": ["ANP", "levels", "are", "increased", "in", "a", "wide", "variety", "of", "C0018799#ent", "<e1>", "as", "hypertension", ",", "diabetes", ",", "congestive", "heart", "failure", "myocardial", "infarction", "C0018824#ent", "<e2>"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [21, 22]}}
{"token": ["C0018799#ent", "<e1>", "a", "frequent", "complication", "of", "the", "carcinoid", "syndrome", "usually", "presenting", "as", "C0018824#ent", "<e2>"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [12, 13]}}
{"token": ["This", "C0031727#ent", "<e1>", "is", "a", "heterodimer", "of", "C1565306#ent", "<e2>", "and", "p35nck5a", "and", "influences", "neuronal", "maturation", "sprouting", "in", "the", "normal", "brain"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1565306", "name": "C1565306#ent", "pos": [7, 8]}}
{"token": ["In", "mammalian", "neurons", ",", "one", "C0031727#ent", "<e1>", "that", "phosphorylates", "these", "axonal", "cytoskeletal", "proteins", "C1565306#ent", "<e2>", "cdk5", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1565306", "name": "C1565306#ent", "pos": [13, 14]}}
{"token": ["The", "catalytic", "domain", "C1334043#ent", "<e1>", "to", "those", "of", "CelA", "and", "C1705072#ent", "<e2>", "of", "the", "same", "fungus", "and", "to", "that", "of", "the", "Neocallimastix", "patriciarum", "CELA", "but", "CelF", "lacks", "a", "docking", "domain", "characteristic", "for", "enzymes", "of", "cellulosomes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705072", "name": "C1705072#ent", "pos": [10, 11]}}
{"token": ["The", "endothelial", "C3b", "receptor", "the", "oral", "mucosa", "have", "an", "important", "function", "in", "the", "localization", "of", "immune", "complexes", "occur", "in", "C0442893#ent", "<e1>", "as", "well", "as", "in", "C0012634#ent", "<e2>", "restricted", "to", "the", "oral", "mucosa"], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [25, 26]}}
{"token": ["We", "used", "four", "complementary", "DNAs", "(", "cDNAs", ")", "for", "multidrug", "resistance", "MDR1", ")", ",", "glutathione", "S-transferase-pi", "C0537086#ent", "<e1>", ")", ",", "thymidylate", "synthase", "TS", ")", "and", "C3853636#ent", "<e2>", "DHFR", ")", ",", "as", "probes", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3853636", "name": "C3853636#ent", "pos": [25, 26]}}
{"token": ["Phenotypic", "cross-resistance", "against", "the", "C0011880#ent", "<e1>", "analogue", "CHI-1043", "and", "MK-0518", "was", "modest", "but", "that", "against", "C1700388#ent", "<e2>", "was", "pronounced", "."], "h": {"id": "C0011880", "name": "C0011880#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1700388", "name": "C1700388#ent", "pos": [15, 16]}}
{"token": ["C1704467#ent", "<e1>", "over-expression", "abrogated", "cytochrome", "c", "release", "apoptosis", ",", "and", "also", "blocked", "C0667830#ent", "<e2>", "activation", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0667830", "name": "C0667830#ent", "pos": [12, 13]}}
{"token": ["Comparison", "of", "the", "two", "C0033613#ent", "<e1>", "that", "the", "reduction", "in", "stroke", "rate", "on", "C0004975#ent", "<e2>", "was", "greater", "than", "that", "on", "propranolol", "(", "p", "=", "0.002", ")", "."], "h": {"id": "C0033613", "name": "C0033613#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004975", "name": "C0004975#ent", "pos": [13, 14]}}
{"token": ["Two", "of", "the", "C0018081#ent", "<e1>", "immunologically", "cross-reactive", "with", "the", "hsps", "of", "Escherichia", "coli", "DnaK", "and", "C3538704#ent", "<e2>", ",", "as", "demonstrated", "by", "Western", "blot", "immunoblot", ")", "analysis", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [15, 16]}}
{"token": ["Phaclofen", "also", "inhibited", "the", "pressor", "response", "elicited", "by", "injection", "into", "the", "C1417869#ent", "<e1>", "of", "another", "indirectly", "acting", "GABA", "C2987634#ent", "<e2>", ",", "gamma-vinylGABA", "(", "GVG", ")", "."], "h": {"id": "C1417869", "name": "C1417869#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "whether", "C0733383#ent", "<e1>", "inhibited", "the", "activation", "(", "i.e.", ",", "dephosphorylation", ")", "of", "C0729078#ent", "<e2>", "to", "WR-1065", ",", "we", "assayed", "WR-1065", "in", "the", "jejunum", "using", "an", "HPLC", "electrochemical", "assay", "."], "h": {"id": "C0733383", "name": "C0733383#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0729078", "name": "C0729078#ent", "pos": [14, 15]}}
{"token": ["Simultaneous", "addition", "of", "the", "C0038317#ent", "<e1>", "with", "mitogen", "reduced", "mitogen-induced", "C1565860#ent", "<e2>", "mRNA", "levels", "by", "80", "%", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [10, 11]}}
{"token": ["Neither", "proliferation", "nor", "migration", "was", "affected", "in", "primary", "cultures", "whereas", "C1423502#ent", "<e1>", "partly", "inhibited", "proliferation", "in", "C1424252#ent", "<e2>", "and", "FRO", "cells"], "h": {"id": "C1423502", "name": "C1423502#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1424252", "name": "C1424252#ent", "pos": [16, 17]}}
{"token": ["Endogenous", "C1414463#ent", "<e1>", "was", "co-immunoprecipitated", "with", "C0694891#ent", "<e2>", ",", "and", "the", "interaction", "was", "induced", "by", "antiestrogen", "ligands", "as", "tamoxifen", ",", "raloxifene", ",", "and", "droloxifen", ",", "which", "was", "confirmed", "in", "chromatin", "immunoprecipitation", "assays"], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0694891", "name": "C0694891#ent", "pos": [6, 7]}}
{"token": ["Preliminary", "results", "from", "studies", "in", "patients", "with", "chronic", "asthma", "that", "C0033051#ent", "<e1>", "only", "has", "an", "insignificant", "C0001645#ent", "<e2>", "when", "the", "drug", "is", "administered", "in", "doses", "which", "induce", "a", "significant", "beta", "1-adrenoceptor", "effect", "."], "h": {"id": "C0033051", "name": "C0033051#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "C0243026#ent", "<e1>", "on", "the", "elimination", "of", "C0178695#ent", "<e2>", "(", "HA", ")", "from", "the", "lung", "interstitium", "was", "investigated", "in", "awake", "sheep", "with", "chronic", "lung", "lymph", "and", "thoracic", "duct", "fistulas"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0178695", "name": "C0178695#ent", "pos": [9, 10]}}
{"token": ["Our", "study", "indicated", "that", "either", "cimetidine", "or", "C0053526#ent", "<e1>", "is", "an", "effective", "drug", "in", "treating", "C0677659#ent", "<e2>"], "h": {"id": "C0053526", "name": "C0053526#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0677659", "name": "C0677659#ent", "pos": [15, 16]}}
{"token": ["We", "ascertained", "the", "effectiveness", "of", "C0053526#ent", "<e1>", "symptoms", "and", "endoscopic", "evaluation", "of", "C0677659#ent", "<e2>", "a", "double-blind", "controlled", "study"], "h": {"id": "C0053526", "name": "C0053526#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0677659", "name": "C0677659#ent", "pos": [12, 13]}}
{"token": ["Cimetidine", "and", "C0053526#ent", "<e1>", "along", "with", "the", "conventional", "medical", "regimen", "C0677659#ent", "<e2>", "also", "be", "helpful", "in", "healing", "the", "inflamed", "mucosa", "."], "h": {"id": "C0053526", "name": "C0053526#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0677659", "name": "C0677659#ent", "pos": [10, 11]}}
{"token": ["It", "can", "be", "concluded", "with", "caution", "that", "consecutive", "treatment", "of", "C0006840#ent", "<e1>", "with", "FCZ", "and", "C0406810#ent", "<e2>", "does", "not", "necessarily", "result", "in", "a", "clinically", "relevant", "antagonism", "."], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0406810", "name": "C0406810#ent", "pos": [15, 16]}}
{"token": ["Mutations", "in", "C0949990#ent", "<e1>", "interact", "with", "mutations", "in", "components", "of", "the", "C2919060#ent", "<e2>", "resulting", "in", "synthetic", "lethality", "loss", "of", "male", "sensory", "neurons", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2919060", "name": "C2919060#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "expression", "patterns", "of", "C1420810#ent", "<e1>", "in", "human", "arthritic", "synovium", "the", "role", "of", "C1420810#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0003873#ent", "<e1>", "RA", ")", "."], "h": {"id": "C1420810", "name": "C1420810#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}}
{"token": ["Acetazolamide", "and", "dichlorphenamide", "are", "C1413038#ent", "<e1>", "CA", ")", "inhibitors", "effective", "in", "the", "clinical", "condition", "hypokalemic", "periodic", "paralysis", "C1413064#ent", "<e2>", ")", "."], "h": {"id": "C1413038", "name": "C1413038#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413064", "name": "C1413064#ent", "pos": [17, 18]}}
{"token": ["There", "are", "also", "case", "reports", "pancreatitis", "associated", "with", "C3540783#ent", "<e1>", "and", "information", "on", "rare", "adverse", "reactions", "associated", "with", "C1142985#ent", "<e2>", "is", "sparse", "."], "h": {"id": "C3540783", "name": "C3540783#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1142985", "name": "C1142985#ent", "pos": [18, 19]}}
{"token": ["Here", "we", "characterize", "the", "Caenorhabditis", "elegans", "C0017337#ent", "<e1>", ",", "encoding", "an", "MKP", "that", "acts", "preferentially", "on", "the", "C0248813#ent", "<e2>", "JNK", ")", "and", "p38", "MAPKs"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [17, 18]}}
{"token": ["Motor", "neuronal", "disorders", "such", "as", "the", "loss", "of", "spinal", "cord", "neurons", "in", "C1862939#ent", "<e1>", "the", "degeneration", "of", "spinal", "cord", "motor", "neuron", "axons", "in", "certain", "C0270932#ent", "<e2>", "present", "a", "unique", "opportunity", "for", "therapeutic", "intervention", "neurotrophic", "proteins"], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0270932", "name": "C0270932#ent", "pos": [24, 25]}}
{"token": ["Studies", "are", "lacking", "that", "assess", "the", "value", "of", "informal", "community-level", "transfers", ",", "describe", "how", "safety", "C1423506#ent", "<e1>", "assist", "the", "poor", "or", "analyse", "modifications", "in", "response", "to", "C2963174#ent", "<e2>", "."], "h": {"id": "C1423506", "name": "C1423506#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2963174", "name": "C2963174#ent", "pos": [26, 27]}}
{"token": ["The", "C0040615#ent", "<e1>", "the", "psychostimulant", "d-amphetamine", ",", "the", "putative", "anxiogenics", "C0066212#ent", "<e2>", "and", "m-CPP", "and", "the", "putative", "anxiolytics", "ondansetron", "and", "CI-988", "had", "no", "effect", "isolation", "calls", "of", "guinea", "pig", "pups", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0066212", "name": "C0066212#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "determine", "large", "artery", "phenotype", "in", "patients", "with", "pseudoxanthoma", "elasticum", "C3890184#ent", "<e1>", ")", ",", "a", "genetic", "disease", "by", "C1418888#ent", "<e2>", "accumulation", "and", "fragmented", "elastic", "fibers", "connective", "tissues"], "h": {"id": "C3890184", "name": "C3890184#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [25, 26]}}
{"token": ["We", "have", "previously", "shown", "that", "C0087140#ent", "<e1>", "modulates", "in", "different", "manners", "the", "activity", "of", "phospholipase", "A2", "phospholipase", "C", "C0872351#ent", "<e2>", "of", "dilauroylphosphatidylcholine", "(", "PC", ")", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [18, 19]}}
{"token": ["Our", "results", "show", "that", "C0087140#ent", "<e1>", "expression", "is", "prolonged", "in", "keratinocyte", "C0872351#ent", "<e2>", "both", "at", "the", "mRNA", "and", "protein", "level"], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [11, 12]}}
{"token": ["The", "livers", "from", "a", "patient", "with", "C0268165#ent", "<e1>", "D-glycerate", "dehydrogenase", "deficiency", "and", "one", "with", "an", "undefined", "form", "of", "C0020501#ent", "<e2>", "possibly", "oxalate", "hyperabsorption", ")", "had", "normal", "AGT", "levels", "."], "h": {"id": "C0268165", "name": "C0268165#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0020501", "name": "C0020501#ent", "pos": [18, 19]}}
{"token": ["The", "livers", "from", "a", "patient", "with", "primary", "hyperoxaluria", "type", "2", "C0268165#ent", "<e1>", "and", "one", "with", "an", "undefined", "form", "of", "C0020501#ent", "<e2>", "possibly", "oxalate", "hyperabsorption", ")", "had", "normal", "AGT", "levels", "."], "h": {"id": "C0268165", "name": "C0268165#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0020501", "name": "C0020501#ent", "pos": [19, 20]}}
{"token": ["C0162809#ent", "<e1>", "a", "disease", "clinically", "characterized", "by", "the", "association", "of", "C0271623#ent", "<e2>", "anosmia", "or", "hyposmia", "."], "h": {"id": "C0162809", "name": "C0162809#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [10, 11]}}
{"token": ["Rifampicin", "is", "one", "of", "the", "most", "effective", "antibiotics", "used", "for", "the", "treatment", "of", "C0041296#ent", "<e1>", "and", "severe", "C0038166#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038166", "name": "C0038166#ent", "pos": [17, 18]}}
{"token": ["C0005214#ent", "<e1>", "is", "highly", "effective", "in", "reducing", "postoperative", "C0013608#ent", "<e2>", "and", "swellings", "."], "h": {"id": "C0005214", "name": "C0005214#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013608", "name": "C0013608#ent", "pos": [8, 9]}}
{"token": ["Pretreatment", "with", "NEM", "and", "C1417154#ent", "<e1>", "enhanced", "the", "Ni", "accumulation", "by", "C0669372#ent", "<e2>", "to", "maximum", "of", "156", "and", "73", "%", ",", "respectively", "."], "h": {"id": "C1417154", "name": "C1417154#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [11, 12]}}
{"token": ["C0012544#ent", "<e1>", "an", "important", "component", "of", "palliative", "care", "patients", "with", "bone", "metastases", "and", "C0356588#ent", "<e2>", "has", "been", "the", "standard", "of", "care", "patients", "with", "breast", "cancer", "multiple", "myeloma", "1996", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0356588", "name": "C0356588#ent", "pos": [13, 14]}}
{"token": ["Both", "tested", "C0012544#ent", "<e1>", ",", "clodronate", "and", "C0356588#ent", "<e2>", ",", "reduced", "the", "arterial", "contractile", "force", "induced", "by", "alpha-adrenergic", "stimulation", "noradrenaline", "and", "membrane", "depolarization", "high", "concentration", "of", "KCl", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [2, 3]}, "relation": "structural_class_of", "t": {"id": "C0356588", "name": "C0356588#ent", "pos": [7, 8]}}
{"token": ["C0012544#ent", "<e1>", "such", "as", "C0356588#ent", "<e2>", "inhibit", "osteoclast-induced", "bone", "resorption", "associated", "with", "cancer", "that", "has", "metastasized", "to", "bone", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0356588", "name": "C0356588#ent", "pos": [4, 5]}}
{"token": ["The", "moaF", "gene", "encoding", "a", "30-kDa", "protein", ",", "which", "is", "induced", "by", "C0026454#ent", "<e1>", ",", "also", "forms", "an", "C0022895#ent", "<e2>", "with", "the", "moaE", "gene", "."], "h": {"id": "C0026454", "name": "C0026454#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "human", "C1333359#ent", "<e1>", "rise", "to", "an", "inherited", "photosensitive", "disorder", "xeroderma", "pigmentosum", "XP", ")", "associated", "with", "C0009207#ent", "<e2>", "XP-G/CS", ")", "."], "h": {"id": "C1333359", "name": "C1333359#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "C1333359#ent", "<e1>", "can", "lead", "to", "the", "disorders", "xeroderma", "pigmentosum", "XP", ")", "and", "C0009207#ent", "<e2>"], "h": {"id": "C1333359", "name": "C1333359#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [14, 15]}}
{"token": ["Persistent", "blockade", "of", "C0751950#ent", "<e1>", "also", "defined", "in", "C0010340#ent", "<e2>", "patients", "."], "h": {"id": "C0751950", "name": "C0751950#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010340", "name": "C0010340#ent", "pos": [8, 9]}}
{"token": ["Previous", "reports", "have", "described", "prolonged", "paralysis", "after", "treatment", "with", "C0751950#ent", "<e1>", "NMJ", ")", "blocking", "agents", "in", "C0010340#ent", "<e2>", "patients", "."], "h": {"id": "C0751950", "name": "C0751950#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010340", "name": "C0010340#ent", "pos": [16, 17]}}
{"token": ["The", "OGD-induced", "switch", "in", "receptor", "subunit", "composition", "requires", "C3539645#ent", "<e1>", "activation", ",", "dissociation", "of", "GluR2", "from", "AMPA", "C1709139#ent", "<e2>", "and", "association", "with", "protein", "interacting", "C", "kinase-1"], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1709139", "name": "C1709139#ent", "pos": [17, 18]}}
{"token": ["To", "examine", "the", "efficacy", "of", "C0113286#ent", "<e1>", "DEX", ")", "iontophoresis", "for", "the", "treatment", "of", "C0038013#ent", "<e2>", "RA", ")", "of", "the", "knee", ",", "and", "to", "obtain", "statistical", "information", "a", "future", "randomized", "controlled", "trial", "RCT", ")", "."], "h": {"id": "C0113286", "name": "C0113286#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [14, 15]}}
{"token": ["Pharmacologic", "agents", "settled", "on", "vasodilators", "of", "cochlear", "microcirculation", "nimodipine", ",", "trimetazidine", ",", "Ginkgo", "biloba", "extract", "misoprostol", ")", ",", "C0360097#ent", "<e1>", ",", "the", "anxiolitics", "(", "alprazolam", ",", "C0024002#ent", "<e2>", ")", "and", "the", "antidepressants", "(", "nortrityline", ")", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0024002", "name": "C0024002#ent", "pos": [26, 27]}}
{"token": ["Aberrance", "in", "this", "function", "is", "either", "the", "cause", "or", "one", "of", "the", "major", "contributors", "to", "the", "pathogenesis", "of", "various", "C0024115#ent", "<e1>", "such", "as", "asthma", "and", "C0006277#ent", "<e2>", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [19, 20]}, "relation": "nichd_parent_of", "t": {"id": "C0006277", "name": "C0006277#ent", "pos": [25, 26]}}
{"token": ["The", "potential", "to", "inhibit", "drug", "metabolism", "the", "new", "antifungal", "agent", "C0771029#ent", "<e1>", "has", "been", "studied", "using", "C0003420#ent", "<e2>", "(", "single", "oral", "dose", "10", "mg/kg", ")", "as", "a", "probe", "drug"], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003420", "name": "C0003420#ent", "pos": [16, 17]}}
{"token": ["At", "low", "concentrations", "of", "FKBP12/FK506", ",", "C1334912#ent", "<e1>", "containing", "the", "alpha", "isoform", "is", "more", "sensitive", "to", "inhibition", "than", "C1334912#ent", "<e1>", "containing", "the", "C0597298#ent", "<e1>", "the", "phosphopeptide", "substrates", "."], "h": {"id": "C1334912", "name": "C1334912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [22, 23]}}
{"token": ["C0078703#ent", "<e1>", "may", "be", "characterized", "as", "a", "highly", "potent", "C0013227#ent", "<e2>", "with", "vasoselectivity", "and", ",", "accordingly", ",", "a", "lack", "of", "negative", "inotropic", "activity", "."], "h": {"id": "C0078703", "name": "C0078703#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}}
{"token": ["In", "an", "experimental", "study", "onset", "and", "C0720099#ent", "<e1>", "of", "immunity", "after", "oral", "immunisation", "pigs", "with", "a", "C0019841#ent", "<e2>", "CSF", ")", "live", "virus", "vaccine", "based", "on", "the", "strain", "\"", "C", "\"", "has", "been", "evaluated", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019841", "name": "C0019841#ent", "pos": [16, 17]}}
{"token": ["Recently", ",", "we", "have", "shown", "that", "C1420314#ent", "<e1>", "has", "the", "capacity", "to", "induce", "both", "growth", "inhibition", "and", "C1418401#ent", "<e2>", "aflatoxin-transformed", "(", "AFLB8", ")", "rat", "liver", "epithelial", "cells"], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418401", "name": "C1418401#ent", "pos": [17, 18]}}
{"token": ["Diclofenac", "sodium", "C0037502#ent", "<e1>", ",", "Geigy", "Pharmaceuticals", "is", "a", "C0003211#ent", "<e2>", "phenylacetic", "acid"], "h": {"id": "C0037502", "name": "C0037502#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [9, 10]}}
{"token": ["The", "C0010656#ent", "<e1>", "cathepsin", "L", "the", "metalloproteases", "thermolysin", "angiotensin-converting", "enzyme", "and", "C0025250#ent", "<e2>", "EC", "3.4.24.11", "also", "cleaved", "nitrobradykinin", ",", "but", "at", "different", "peptide", "bonds", "meprin", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025250", "name": "C0025250#ent", "pos": [11, 12]}}
{"token": ["To", "investigate", "the", "cellular", "events", "accompany", "C0014800#ent", "<e1>", "we", "studied", "several", "effects", "of", "erythropoietin", "(", "C1414438#ent", "<e2>", ")", "on", "marrow", "CFU-E", "in", "sickle", "cell", "anemia", "SCA", ")", "."], "h": {"id": "C0014800", "name": "C0014800#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [15, 16]}}
{"token": ["Competitive", "functional", "interactions", "among", "C1706113#ent", "<e1>", ",", "PXR", ",", "and", "C3889135#ent", "<e2>", "suggest", "that", "the", "intracellular", "hormonal", "and", "metabolic", "milieu", "may", "determine", "the", "extent", "to", "which", "a", "specific", "nuclear", "receptor", "pathway", "influence", "steroid/xenobiotic", "metabolism", "dehydroepiandrosterone", "sulfotransferase"], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889135", "name": "C3889135#ent", "pos": [10, 11]}}
{"token": ["This", "technique", "was", "applied", "to", "C0015674#ent", "<e1>", "samples", "from", "213", "patients", "in", "whom", "neonatal", "septicaemia", "and/or", "C0025289#ent", "<e2>", "or", "bacterial", "meningitis", "suspected", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [16, 17]}}
{"token": ["Neomycin", ",", "a", "C0013227#ent", "<e1>", "which", "prevents", "C4277588#ent", "<e2>", "inhibits", "exocytosis", "in", "vitro"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4277588", "name": "C4277588#ent", "pos": [7, 8]}}
{"token": ["Permanent", "neonatal", "diabetes", "mellitus", "C1833104#ent", "<e1>", ")", "is", "a", "rare", "condition", "characterized", "by", "severe", "C0020456#ent", "<e2>", "constantly", "requiring", "insulin", "treatment", "from", "its", "onset", "."], "h": {"id": "C1833104", "name": "C1833104#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [14, 15]}}
{"token": ["We", "found", "that", "the", "SPL-binding", "site", "of", "RGS8", "is", "the", "C4283882#ent", "<e1>", "sequence", ",", "and", "the", "M1", "receptor", "C0037982#ent", "<e2>", "compete", "for", "binding", "to", "RGS8", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [18, 19]}}
{"token": ["These", "patients", "are", "considered", "at", "high", "risk", "skin-related", "complications", "during", "C1861305#ent", "<e1>", "because", "of", "C0151313#ent", "<e2>"], "h": {"id": "C1861305", "name": "C1861305#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [14, 15]}}
{"token": ["Moxifloxacin", "does", "not", "inhibit", "cytochrome", "P450", "C3540790#ent", "<e1>", "and", "thus", "interact", "with", "warfarin", "or", "C0066447#ent", "<e2>", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0066447", "name": "C0066447#ent", "pos": [14, 15]}}
{"token": ["From", "a", "series", "of", "formulations", "of", "linear", "and", "branched", "polyethylene", "glycols", "conjugated", "to", "C1539766#ent", "<e1>", ",", "we", "have", "created", "a", "parenteral", "therapeutic", "agent", "C0031485#ent", "<e2>", "treatment", "."], "h": {"id": "C1539766", "name": "C1539766#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [23, 24]}}
{"token": ["C0040560#ent", "<e1>", "in", "contrast", ",", "resulted", "in", "sustained", "activation", "of", "this", "C0031727#ent", "<e2>", "."], "h": {"id": "C0040560", "name": "C0040560#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["Polyamine", "depletion", "stimulated", "C1704851#ent", "<e1>", "expression", "primarily", "by", "increasing", "C1704851#ent", "<e1>", "gene", "transcription", "its", "mRNA", "stability", "and", "it", "induced", "C1704851#ent", "<e1>", "nuclear", "translocation", "activation", "of", "phosphorylation", "of", "C0169101#ent", "<e1>"], "h": {"id": "C1704851", "name": "C1704851#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [27, 28]}}
{"token": ["The", "major", "secreted", "collagenous", "polypeptides", "identified", "as", "C1332772#ent", "<e1>", "its", "precursors", "by", "using", "pulse-chase", "studies", ",", "pepsin", "and", "C0162745#ent", "<e2>", "CNBr", "fragmentation", "."], "h": {"id": "C1332772", "name": "C1332772#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [18, 19]}}
{"token": ["The", "distribution", "of", "PpM", "phi", "could", "be", "altered", "by", "activation", "of", "these", "cells", "in", "vivo", "the", "C3273618#ent", "<e1>", "injection", "of", "the", "C0034231#ent", "<e2>", "MVE-2", ",", "prior", "to", "adoptive", "IV", "transfer"], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034231", "name": "C0034231#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "we", "isolated", "and", "characterized", "three", "novel", "rice", "cDNAs", "for", "C1421886#ent", "<e1>", ",", "OsTIP2", ",", "and", "OsTIP3", "that", "are", "C1334043#ent", "<e2>", "to", "rice", "gamma-TIP", "cDNA", "."], "h": {"id": "C1421886", "name": "C1421886#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [22, 23]}}
{"token": ["The", "patients", "had", "varying", "clinical", "features", ",", "commonly", "characterized", "by", "C0034735#ent", "<e1>", "phenomenon", ",", "arthritis", ",", "abnormal", "pulmonary", "function", "and", "C0014863#ent", "<e2>"], "h": {"id": "C0034735", "name": "C0034735#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014863", "name": "C0014863#ent", "pos": [20, 21]}}
{"token": ["The", "two", "molecules", "display", "antibacterial", "activity", "gram-positive", "bacteria", "whereas", "only", "C0597298#ent", "<e1>", "active", "against", "the", "fungus", "Fusarium", "oxysporum", "a", "C0085423#ent", "<e2>", "Escherichia", "coli", "D31"], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [19, 20]}}
{"token": ["Nasal", "reactivity", "C0006945#ent", "<e1>", "was", "evaluated", "by", "measuring", "the", "amount", "of", "C1260880#ent", "<e2>", "following", "variable", "concentrations", "(", "1/1000", ",", "1/100", ",", "1/25", ")", "and", "volumes", "(", "0,10", "to", "0,50", "ml", ")", "of", "carbacholine", "solution"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [11, 12]}}
{"token": ["Short-term", "cultivated", "rat", "C0669372#ent", "<e1>", "were", "allowed", "to", "endocytose", "fluorescein", "isothiocyanate", "C0011806#ent", "<e2>", "and", "the", "apparent", "vesicular", "pH", "(", "pHves", ")", "was", "measured", "by", "single-cell", "fluorescence", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011806", "name": "C0011806#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "the", "order", "of", "effectiveness", "in", "protecting", "the", "calcium", "overloaded", "myocardium", "is", "consistent", "with", "potency", "as", "C0021643#ent", "<e1>", "trifluoperazine", "greater", "than", "C0033399#ent", "<e2>", "greater", "than", "promethazine", ")", "."], "h": {"id": "C0021643", "name": "C0021643#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0033399", "name": "C0033399#ent", "pos": [22, 23]}}
{"token": ["A", "58-year-old", "patient", "with", "C0023530#ent", "<e1>", "due", "to", "SLE", "developed", "C0263854#ent", "<e2>", "of", "the", "lumbar", "region", "by", "Candida", "albicans"], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0263854", "name": "C0263854#ent", "pos": [10, 11]}}
{"token": ["An", "intranasal", "route", "administration", "appears", "to", "be", "an", "obvious", "way", "to", "deliver", "a", "C0149931#ent", "<e1>", "treatment", "and", "two", "triptans", ",", "sumatriptan", "and", "C0528166#ent", "<e2>", ",", "are", "available", "in", "nasal", "spray", "formulations"], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0528166", "name": "C0528166#ent", "pos": [22, 23]}}
{"token": ["The", "defect", "appeared", "to", "be", "primary", "in", "3", "patients", ",", "secondary", "to", "C0020455#ent", "<e1>", "2", "patients", "and", "secondary", "to", "C0004623#ent", "<e2>", "5", "patients", "."], "h": {"id": "C0020455", "name": "C0020455#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [19, 20]}}
{"token": ["In", "its", "major", "form", ",", "C0019880#ent", "<e1>", ",", "is", "due", "to", "C0751202#ent", "<e2>"], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0751202", "name": "C0751202#ent", "pos": [11, 12]}}
{"token": ["The", "establishment", "of", "latency", "was", "not", "prevented", "and", "a", "single", "dose", "HPMPC", ",", "the", "day", "before", "a", "course", "of", "C0011777#ent", "<e1>", "(", "6", "weeks", "after", "the", "C0149512#ent", "<e2>", ",", "did", "not", "prevent", "virus", "shedding"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [26, 27]}}
{"token": ["Human", "spongiform", "encephalopathies", "C1537381#ent", "<e1>", ")", "are", "uncommon", "C0751870#ent", "<e2>", "unknown", "etiology", "."], "h": {"id": "C1537381", "name": "C1537381#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [8, 9]}}
{"token": ["Cotransfection", "of", "YSR2", "with", "C2987364#ent", "<e1>", "C0919432#ent", "<e2>", ",", "but", "not", "with", "the", "phosphorylation-deficient", "mutant", "of", "C0919432#ent", "<e2>", "(", "Smad3A", ")", ",", "resulted", "in", "a", "dramatic", "increase", "of", "COL1A2", "promoter", "activity", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919432", "name": "C0919432#ent", "pos": [6, 7]}}
{"token": ["Here", ",", "we", "studied", "the", "function", "of", "Smad2Deltaexon3", "and", "compared", "it", "with", "those", "of", "C2987364#ent", "<e1>", "Smad2", "containing", "exon", "3", "Smad2(wt", ")", ")", "and", "C0919432#ent", "<e2>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0919432", "name": "C0919432#ent", "pos": [24, 25]}}
{"token": ["The", "disposition", "of", "C1334043#ent", "<e1>", "and", "heterologous", "C1412332#ent", "<e2>", "conjugated", "with", "3H-dinitrophenyl", "groups", "(", "3H-DNP", ")", "has", "been", "investigated", "in", "the", "male", "Wistar", "rat"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [7, 8]}}
{"token": ["Social", "phobia", "often", "accompanied", "by", "C1457887#ent", "<e1>", "as", "trembling", ",", "C0016382#ent", "<e2>", ",", "and", "sweating", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016382", "name": "C0016382#ent", "pos": [10, 11]}}
{"token": ["Nearly", "half", "of", "all", "Orientals", "exhibit", "C1457887#ent", "<e1>", "such", "as", "\"", "C0016382#ent", "<e2>", "or", "palpitation", ",", "during", "alcohol", "consumption"], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016382", "name": "C0016382#ent", "pos": [11, 12]}}
{"token": ["Pathological", "examinations", "that", "both", "patients", "with", "anaplastic", "large", "cell", "lymphoma", "type", "C1707163#ent", "<e1>", "had", "cytoplasmic", "NSE", "and", "C1456796#ent", "<e2>", "markers", "on", "cell", "membranes"], "h": {"id": "C1707163", "name": "C1707163#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1456796", "name": "C1456796#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "the", "C1413581#ent", "<e1>", "and", "COL5A2", "genes", "to", "exist", "as", "a", "C1418864#ent", "<e2>", "chromosome", "2"], "h": {"id": "C1413581", "name": "C1413581#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418864", "name": "C1418864#ent", "pos": [12, 13]}}
{"token": ["We", "therefore", "studied", "common", "C0042420#ent", "<e1>", "and", "sympathetic", "reflexes", "12", "patients", "with", "C1836438#ent", "<e2>", "(", "mean", "age", "(", "18", "-", "75", ")", "years", ",", "6", "men", ")", "."], "h": {"id": "C0042420", "name": "C0042420#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C1836438", "name": "C1836438#ent", "pos": [12, 13]}}
{"token": ["These", "P2", "receptors", "a", "C0221232#ent", "<e1>", "of", "physiological", "processes", "including", "nitric", "oxide-dependent", "vasodilation", "of", "C1412137#ent", "<e2>", "fast", "excitatory", "neurotransmission", "in", "sensory", "afferents"], "h": {"id": "C0221232", "name": "C0221232#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [14, 15]}}
{"token": ["Platycodi", "Radix", "is", "the", "root", "of", "Platycodon", "grandiflorum", "it", "is", "widely", "used", "in", "the", "traditional", "Oriental", "medicine", "an", "expectorant", "for", "C0024115#ent", "<e1>", "a", "remedy", "for", "C0035204#ent", "<e2>"], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [20, 21]}, "relation": "has_nichd_parent", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [25, 26]}}
{"token": ["To", "test", "whether", "C0022735#ent", "<e1>", "patients", "with", "47,XXY", "karyotype", "or", "infertile", "men", "with", "C2751824#ent", "<e2>", "karyotype", "represent", "gonosomal", "mosaicisms", ",", "we", "performed", "meta-", "and", "interphase", "fluorescence", "in", "situ", "hybridization", "FISH", ")", "on", "45", "men", "."], "h": {"id": "C0022735", "name": "C0022735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2751824", "name": "C2751824#ent", "pos": [13, 14]}}
{"token": ["C0022735#ent", "<e1>", "HH", ")", "was", "diagnosed", "in", "a", "22-year-old", "patient", "with", "C2751824#ent", "<e2>", ",", "inv(10", ")", "karyotype", "."], "h": {"id": "C0022735", "name": "C0022735#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2751824", "name": "C2751824#ent", "pos": [11, 12]}}
{"token": ["Both", "C0086376#ent", "<e1>", "are", "antigenetically", "related", "to", "C1415350#ent", "<e2>", ",", "a", "previously", "described", "protein", "of", "Xenopus", "laevis", "which", "is", "known", "as", "a", "5S", "RNA", "transcription", "factor", "occurs", "in", "oocytes", "as", "a", "noncovalent", "complex", "with", "5S", "RNA"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415350", "name": "C1415350#ent", "pos": [7, 8]}}
{"token": ["In", "C0086376#ent", "<e1>", "possessing", "multiple", "zinc", "fingers", "including", "C1415350#ent", "<e2>", ",", "Sp1", ",", "SWI5", "and", "oestrogen/glucocorticoid", "receptors", "the", "region", "containing", "the", "zinc", "fingers", "DNA-binding", "specificity", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415350", "name": "C1415350#ent", "pos": [8, 9]}}
{"token": ["Likewise", ",", "C0010977#ent", "<e1>", "delayed", "the", "onset", "of", "the", "C0051844#ent", "<e2>", "II-induced", "increase", "in", "aldosterone", "secretion", "and", "reduced", "the", "maximal", "rate", "of", "secretion", "to", "50", "%", "."], "h": {"id": "C0010977", "name": "C0010977#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [9, 10]}}
{"token": ["This", "paper", "reviews", "the", "efficacy", "of", "C0040615#ent", "<e1>", ",", "antidepressants", "(", "TCA", ",", "C3536878#ent", "<e2>", "and", "SSRI", ")", ",", "lithium", "carbonate", "carbamazepine", "and", "benzodiazepines", "against", "these", "4", "symptom", "domains"], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3536878", "name": "C3536878#ent", "pos": [13, 14]}}
{"token": ["The", "punctate", "C2827446#ent", "<e1>", "colocalized", "with", "C0007427#ent", "<e2>", "a", "lysosomal", "marker", ",", "but", "not", "with", "markers", "of", "endoplasmic", "reticulum", "Golgi", ",", "indicating", "that", "Cbln1", "is", "present", "in", "neuronal", "endosomes/lysosomes", "."], "h": {"id": "C2827446", "name": "C2827446#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [6, 7]}}
{"token": ["MEN", "10,627", "is", "endowed", "with", "high", "affinity", "for", "C1420563#ent", "<e1>", "expressed", "in", "various", "species", "with", "C1705341#ent", "<e2>", "values", "ranging", "between", "10.1", "(", "hamster", "trachea", ")", "and", "8.1", "(", "rabbit", "pulmonary", "artery", "."], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [15, 16]}}
{"token": ["The", "rPAI-1(23", ")", "anti-angiogenic", "activity", "inhibits", "C1522505#ent", "<e1>", "pro-angiogenic", "functions", "by", "blocking", "C1522505#ent", "<e1>", "signaling", "through", "C1333542#ent", "<e1>", "syndecan-4", "and", "downstream", "effectors", "p-Akt", ",", "p-JNK", ",", "and", "p-c-Jun", "."], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333542", "name": "C1333542#ent", "pos": [16, 17]}}
{"token": ["The", "mutation", "was", "located", "at", "min", "8.5", "close", "to", "the", "C0812234#ent", "<e1>", "defines", "a", "new", "genetic", "locus", "called", "C1538038#ent", "<e2>", "(", "for", "negative", "alkaline", "phosphatase", "pleiotropic", "phenotype", ")", "."], "h": {"id": "C0812234", "name": "C0812234#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1538038", "name": "C1538038#ent", "pos": [18, 19]}}
{"token": ["Brain", "specific", "proteins", "such", "as", "14", "-", "3", "-", "3", "protein", ",", "tau", "protein", "and", "neuron", "specific", "enolase", "(", "C1414404#ent", "<e1>", ")", "are", "detected", "in", "the", "CSF", "of", "C2347435#ent", "<e2>", "patients", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [28, 29]}}
{"token": ["SSRIs", "(", "e.g.", "fluoxetine", ",", "sertraline", "and", "C0085228#ent", "<e1>", ")", "were", "amongst", "the", "first", "C0033978#ent", "<e2>", "investigated", "in", "the", "treatment", "of", "obesity", "."], "h": {"id": "C0085228", "name": "C0085228#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [14, 15]}}
{"token": ["Two", "19", "year", "old", "patients", "with", "C3495559#ent", "<e1>", "liver", "toxicity", "treatment", "with", "C0036078#ent", "<e2>", "."], "h": {"id": "C3495559", "name": "C3495559#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "whether", "allelic", "variants", "of", "the", "C1413772#ent", "<e1>", "CST3", "are", "genetically", "associated", "with", "exudative", "age", "C0242383#ent", "<e2>", "ARMD", ")", "."], "h": {"id": "C1413772", "name": "C1413772#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [16, 17]}}
{"token": ["This", "article", "will", "review", "new", "and", "exciting", "developments", "in", "C0149931#ent", "<e1>", "research", ",", "with", "particular", "emphasis", "on", "mutations", "associated", "with", "C0338484#ent", "<e2>", "the", "role", "of", "cortical", "spreading", "in", "its", "pathophysiology", "and", "treatment", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0338484", "name": "C0338484#ent", "pos": [20, 21]}}
{"token": ["The", "strongly", "water-wet", "model", "saturated", "with", "C3541397#ent", "<e1>", "(", "kerosene", "or", "C0026156#ent", "<e2>", "was", "exposed", "to", "distilled", "water", "order", "for", "a", "capillary", "interaction", "to", "take", "place", "under", "static", "conditions"], "h": {"id": "C3541397", "name": "C3541397#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026156", "name": "C0026156#ent", "pos": [11, 12]}}
{"token": ["Local", "and", "generalized", "changes", "in", "coagulation", "may", "be", "important", "in", "the", "C4255166#ent", "<e1>", "of", "vegetations", "and", "embolism", "in", "C1541923#ent", "<e2>"], "h": {"id": "C4255166", "name": "C4255166#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1541923", "name": "C1541923#ent", "pos": [18, 19]}}
{"token": ["FR", "are", "C0025517#ent", "<e1>", "or", "detoxified", "by", "certain", "FRS", "such", "as", "glutathione", "(", "C1260386#ent", "<e2>", "and", "GSSG", ")", ",", "superoxide", "dismutase", "SOD", ")", "and", "enzymes", "such", "as", "epoxide", "hydrolase", "EH", ")", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [13, 14]}}
{"token": ["The", "results", "suggested", "that", "a", "peptide", "hormone", "C1367551#ent", "<e1>", ",", "exerted", "its", "analgesic", "action", "a", "manner", "distinct", "from", "the", "C0242937#ent", "<e2>"], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242937", "name": "C0242937#ent", "pos": [19, 20]}}
{"token": ["C1423497#ent", "<e1>", "is", "a", "novel", "type", "II", "C2825106#ent", "<e2>", "unknown", "function", "that", "is", "expressed", "in", "the", "hepatocytes", "of", "patients", "with", "adult", "giant-cell", "hepatitis", "Gene", "2000;249:53", "-", "65", ")", "."], "h": {"id": "C1423497", "name": "C1423497#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2825106", "name": "C2825106#ent", "pos": [7, 8]}}
{"token": ["C4054543#ent", "<e1>", "MLN", ")", "represents", "about", "20", "%", "of", "clinically", "significant", "renal", "disease", "C0024131#ent", "<e2>", "."], "h": {"id": "C4054543", "name": "C4054543#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024131", "name": "C0024131#ent", "pos": [13, 14]}}
{"token": ["This", "article", "reviews", "the", "important", "features", "of", "the", "anorectal", "examination", "the", "diagnosis", "and", "treatment", "of", "benign", "C0034882#ent", "<e1>", "as", "hemorrhoids", ",", "fissures", ",", "fistulas", ",", "solitary", "rectal", "ulcer", "syndrome", "C0015732#ent", "<e2>", "and", "pruritus", "ani"], "h": {"id": "C0034882", "name": "C0034882#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0015732", "name": "C0015732#ent", "pos": [29, 30]}}
{"token": ["C0034882#ent", "<e1>", "often", "lead", "to", "C0015732#ent", "<e2>", "a", "frequent", "problem", "especially", "in", "elderly", "patients", "."], "h": {"id": "C0034882", "name": "C0034882#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0015732", "name": "C0015732#ent", "pos": [5, 6]}}
{"token": ["The", "rates", "of", "phosphorylation", "and", "dephosphorylation", "for", "the", "proportion", "of", "the", "C0001473#ent", "<e1>", "still", "able", "to", "bind", "C2744579#ent", "<e2>", "are", "unaffected", "by", "reconstitution", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [17, 18]}}
{"token": ["The", "quantum", "yields", "of", "singlet", "oxygen", "production", "C0127602#ent", "<e1>", "been", "measured", "during", "visible", "light", "irradiation", "in", "C0001962#ent", "<e2>", "and", "ethanol", "."], "h": {"id": "C0127602", "name": "C0127602#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [16, 17]}}
{"token": ["We", "show", "that", "overexpression", "of", "C1704912#ent", "<e1>", "potentiates", "ATF7-induced", "transcriptional", "activation", "direct", "interaction", "with", "C1412623#ent", "<e2>", ",", "suggesting", "that", "TAF12", "is", "a", "functional", "partner", "of", "C1412623#ent", "<e2>", "."], "h": {"id": "C1704912", "name": "C1704912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412623", "name": "C1412623#ent", "pos": [14, 15]}}
{"token": ["We", "show", "that", "overexpression", "of", "hsTAF12", "potentiates", "ATF7-induced", "transcriptional", "activation", "direct", "interaction", "with", "C1412623#ent", "<e1>", ",", "suggesting", "that", "C1704912#ent", "<e2>", "is", "a", "functional", "partner", "of", "C1412623#ent", "<e1>", "."], "h": {"id": "C1704912", "name": "C1704912#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1412623", "name": "C1412623#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "two", "kinases", ",", "C1430988#ent", "<e1>", "induced", "kinase", "1", "PINK1", ")", "and", "leucine-rich", "repeat", "kinase", "2", "C1425650#ent", "<e2>", ")", ",", "have", "been", "shown", "to", "segregate", "with", "familial", "forms", "Parkinson's", "disease"], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425650", "name": "C1425650#ent", "pos": [17, 18]}}
{"token": ["Mutations", "in", "two", "kinases", ",", "C1430988#ent", "<e1>", "induced", "kinase", "1", "PINK1", ")", "and", "C1425650#ent", "<e2>", "LRRK2", ")", ",", "have", "been", "shown", "to", "segregate", "with", "familial", "forms", "Parkinson's", "disease"], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425650", "name": "C1425650#ent", "pos": [13, 14]}}
{"token": ["The", "E.", "coli", "placed", "in", "a", "defined", "starvation", "medium", "essentially", "no", "nitrogen", "or", "C0524928#ent", "<e1>", "source", "and", "induced", "initially", "using", "lactose", "or", "isopropylthiogalactoside", "(", "C0039512#ent", "<e2>", ")", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [24, 25]}}
{"token": ["The", "C3890737#ent", "<e1>", "a", "newly", "recognized", "group", "of", "C0004364#ent", "<e2>", "lack", "the", "high", "titers", "self-reactive", "antibodies", "and", "T", "cells", "of", "classic", "autoimmune", "disease"], "h": {"id": "C3890737", "name": "C3890737#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [8, 9]}}
{"token": ["We", "have", "used", "the", "polymerase", "chain", "reaction", "single", "strand", "conformation", "polymorphism", "SSCP", ")", "methods", "to", "analyse", "the", "COL10A1", "gene", "which", "encodes", "collagen", "type", "X", "in", "DNA", "samples", "patients", "with", "C1866688#ent", "<e1>", "SMCD", ")", "and", "other", "related", "forms", "of", "C0265294#ent", "<e2>"], "h": {"id": "C1866688", "name": "C1866688#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0265294", "name": "C0265294#ent", "pos": [38, 39]}}
{"token": ["We", "have", "therefore", "compared", "the", "profile", "of", "C0011519#ent", "<e1>", "micrococcal", "nuclease", "cleavage", "at", "HML", "alpha", "MAT", "alpha", "C1705265#ent", "<e2>", "with", "MATa", "in", "sir-", "and", "SIR+", "strains", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705265", "name": "C1705265#ent", "pos": [17, 18]}}
{"token": ["Living", "locust", "spermatocytes", "were", "treated", "with", "inhibitors", "of", "actin", "(", "latrunculin", "B", "cytochalasin", "D", ",", "C0027096#ent", "<e1>", "(", "BDM", ")", ",", "or", "myosin", "phosphorylation", "C0667301#ent", "<e2>", "and", "ML-7", ")", "."], "h": {"id": "C0027096", "name": "C0027096#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0667301", "name": "C0667301#ent", "pos": [24, 25]}}
{"token": ["Hematologic", "studies", "C0162316#ent", "<e1>", "and", "endoscopy", "showed", "gastric", "erosions", "a", "C0013295#ent", "<e2>"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [10, 11]}}
{"token": ["C0036579#ent", "<e1>", ",", "harmaline", ",", "and", "C0633225#ent", "<e2>", "SOD", "and", "catalase", ")", "attenuated", "alteration", "of", "the", "swelling", ",", "membrane", "potential", "cytochrome", "c", "release", "and", "Ca2", "+", "transport", "in", "mitochondria", "treated", "with", "dopamine", "."], "h": {"id": "C0036579", "name": "C0036579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0633225", "name": "C0633225#ent", "pos": [6, 7]}}
{"token": ["More", "emotional", "words", "were", "correctly", "recognized", "when", "a", "C0795956#ent", "<e1>", "responsivity", "in", "HR", "and", "C1422341#ent", "<e2>", "was", "high", ",", "but", "this", "correlation", "was", "dissociated", "in", "the", "old", "."], "h": {"id": "C0795956", "name": "C0795956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422341", "name": "C1422341#ent", "pos": [14, 15]}}
{"token": ["The", "reversal", "of", "EAE", "by", "BADGE", "and", "T0070907", "was", "associated", "with", "restoration", "of", "neural", "antigen-induced", "T", "cell", "proliferation", ",", "IFNgamma", "production", "and", "C3540579#ent", "<e1>", "differentiation", "inhibited", "by", "C1257987#ent", "<e2>", "and", "15d-PGJ2", "."], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1257987", "name": "C1257987#ent", "pos": [27, 28]}}
{"token": ["Cyclin-dependent", "kinase", "5", "C1332735#ent", "<e1>", ")", "mediates", "neurotoxic", "effects", "phosphorylating", "and", "inhibiting", "C0059037#ent", "<e2>", "."], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [12, 13]}}
{"token": ["The", "convergence", "of", "C1332735#ent", "<e1>", "phosphorylation-dependent", "caspase-mediated", "degradation", "of", "nuclear", "survival", "factors", "exemplified", "by", "C0059037#ent", "<e2>", "may", "represent", "a", "general", "process", "applicable", "to", "the", "regulation", "of", "other", "survival", "factors", "diverse", "neurotoxic", "conditions", "."], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [14, 15]}}
{"token": ["C0017661#ent", "<e1>", "is", "the", "main", "clinical", "manifestation", "C0002726#ent", "<e2>", "."], "h": {"id": "C0017661", "name": "C0017661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [7, 8]}}
{"token": ["Oligomycin", "sensitivity", "conferral", "protein", ",", "in", "the", "absence", "of", "C1412668#ent", "<e1>", "F6", ")", ",", "is", "able", "to", "bind", "the", "C0001473#ent", "<e2>", "to", "mitochondrial", "membranes", "an", "apparent", "association", "constant", "of", "10(6", ")", "M-1", "."], "h": {"id": "C1412668", "name": "C1412668#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [19, 20]}}
{"token": ["Degenerative", "changes", "of", "the", "heart", ",", "C0023899#ent", "<e1>", "and", "kidney", ",", "C0038525#ent", "<e2>", "bone", "marrow", "depression", "and", "increased", "radiopacity", "of", "the", "C0023899#ent", "<e1>", "may", "also", "occur", "."], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [6, 7]}}
{"token": ["The", "C0138965#ent", "<e1>", "associates", "with", "growth", "factor", "receptors", "focal", "contacts", "C1414120#ent", "<e2>", "is", "involved", "in", "signaling", "events"], "h": {"id": "C0138965", "name": "C0138965#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [10, 11]}}
{"token": ["The", "level", "of", "activity", "of", "C0069197#ent", "<e1>", "AGT", ")", ",", "a", "C1334340#ent", "<e2>", "in", "blood", "lymphocytes", "be", "a", "marker", "of", "susceptibility", "to", "lung", "cancer"], "h": {"id": "C0069197", "name": "C0069197#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334340", "name": "C1334340#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "suggest", "that", "early", "in", "the", "process", "of", "transformation", ",", "C0154723#ent", "<e1>", "is", "more", "frequent", ",", "and", "that", "as", "C3542407#ent", "<e2>", "evolves", ",", "fewer", "typical", "attacks", "of", "IHS", "C0154723#ent", "<e1>", "occur", "."], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [20, 21]}}
{"token": ["ECT-induced", "increases", "in", "C1704663#ent", "<e1>", "and", "HR", "were", "less", "marked", "with", "C0033487#ent", "<e2>", "than", "with", "thiopental", "."], "h": {"id": "C1704663", "name": "C1704663#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [11, 12]}}
{"token": ["Regulated", "phosphorylation", "by", "C0033681#ent", "<e1>", "PTKs", ")", ",", "such", "as", "C1704928#ent", "<e2>", ",", "is", "critical", "to", "cellular", "homeostasis"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704928", "name": "C1704928#ent", "pos": [10, 11]}}
{"token": ["Like", "those", "C0991617#ent", "<e1>", ",", "felodipine", "and", "C0071304#ent", "<e2>", "affect", "blood", "pressure", "producing", "peripheral", "vasodilation"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0071304", "name": "C0071304#ent", "pos": [7, 8]}}
{"token": ["Within", "these", "C4042815#ent", "<e1>", "the", "fidelity", "of", "biosynthesis", "depends", "on", "the", "programmed", "interaction", "the", "C3274827#ent", "<e2>", "each", "module", ",", "centered", "around", "the", "acyl", "carrier", "protein", "ACP", ")", "."], "h": {"id": "C4042815", "name": "C4042815#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3274827", "name": "C3274827#ent", "pos": [14, 15]}}
{"token": ["Authors", "survey", "most", "significant", "haemostatic", "complications", "thrombocytopenia", ",", "DIC", ",", "vasculitis", ",", "C2717961#ent", "<e1>", "as", "well", "as", "their", "immune", "and", "C0455988#ent", "<e2>", "pathogenesis", "in", "infectious", "diseases"], "h": {"id": "C2717961", "name": "C2717961#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [20, 21]}}
{"token": ["Four", "asthma", "medications", ",", "salbutamol", ",", "salmeterol", ",", "C0117996#ent", "<e1>", "FP", ")", "and", "beclomethasone", "dipropionate", "C0004906#ent", "<e2>", ")", ",", "currently", "containing", "standard", "CFC", "propellants", ",", "were", "formulated", "with", "HFA134a", "for", "investigation", "."], "h": {"id": "C0117996", "name": "C0117996#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004906", "name": "C0004906#ent", "pos": [15, 16]}}
{"token": ["This", "is", "our", "generic", "label", "the", "clinically", "indistinguishable", "parapox", "C0042769#ent", "<e1>", "from", "farm", "animals", "which", "include", "orf", ",", "milker's", "nodules", "and", "the", "C1418945#ent", "<e2>", "of", "bovine", "papular", "stomatitis"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418945", "name": "C1418945#ent", "pos": [22, 23]}}
{"token": ["Etiologically", "heterogenous", ",", "PMEs", "are", "rare", "and", "mostly", "C3899988#ent", "<e1>", "with", "the", "exception", "of", "autosomal", "dominant", "dentatorubral-pallidoluysian", "atrophy", "C0162666#ent", "<e2>", "ragged", "red", "fibers", "MERRF", ")", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162666", "name": "C0162666#ent", "pos": [18, 19]}}
{"token": ["A", "74-year-old", "woman", "with", "a", "14-year", "history", "of", "C0003873#ent", "<e1>", "admitted", "to", "our", "hospital", "due", "to", "dyspnea", "and", "C0231218#ent", "<e2>", "and", "her", "chest", "X-ray", "film", "computed", "tomography", "right", "pneumothorax"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [18, 19]}}
{"token": ["We", "have", "determined", "that", "C1256254#ent", "<e1>", "and", "ciliary", "body", "significant", "numbers", "of", "cells", "bearing", "C1870006#ent", "<e2>", ",", "indicating", "their", "bone", "marrow", "origin"], "h": {"id": "C1256254", "name": "C1256254#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1870006", "name": "C1870006#ent", "pos": [14, 15]}}
{"token": ["C0000744#ent", "<e1>", "consists", "of", "a", "group", "of", "rare", "heterogeneous", "neurodegenerative", "disorders", "associated", "with", "C0687751#ent", "<e2>", "."], "h": {"id": "C0000744", "name": "C0000744#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0687751", "name": "C0687751#ent", "pos": [13, 14]}}
{"token": ["Inhibition", "of", "pheromone", "signaling", "by", "PRR1", ",", "but", "not", "C1424869#ent", "<e1>", ",", "required", "the", "C0017837#ent", "<e2>"], "h": {"id": "C1424869", "name": "C1424869#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [14, 15]}}
{"token": ["U27391", "exhibited", "chondroprotective", "activity", "and", "confirmed", "the", "induction", "of", "either", "C1334706#ent", "<e1>", "such", "as", "C1723257#ent", "<e2>", "or", "collagenase", "by", "rhIL-1", "beta"], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1723257", "name": "C1723257#ent", "pos": [14, 15]}}
{"token": ["Although", "similar", "reactions", "have", "been", "reported", "with", "the", "antimicrobial", "sulfonamides", "none", "has", "been", "fully", "described", "with", "C0036078#ent", "<e1>", ",", "a", "combination", "of", "a", "sulfonamide", "and", "C0036077#ent", "<e2>", "."], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [25, 26]}}
{"token": ["Analysis", "of", "radiolabelled", "metabolites", "indicated", "that", "estradiol", "and", "C2757070#ent", "<e1>", "could", "be", "produced", "via", "estrogen", "sulfatase", "C3710940#ent", "<e2>", "activities", "in", "certain", "tissues", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3710940", "name": "C3710940#ent", "pos": [16, 17]}}
{"token": ["C0003308#ent", "<e1>", "been", "used", "with", "success", "in", "C0406326#ent", "<e2>"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0406326", "name": "C0406326#ent", "pos": [7, 8]}}
{"token": ["The", "purpose", "of", "this", "clinical", "study", "to", "evaluate", "the", "effect", "of", "a", "3-min", "daily", "toothbrushing", "with", "1", "%", "chlorhexidine", "gluconate", "toothpaste", "dental", "plaque", "C0017574#ent", "<e1>", "and", "gingival", "hyperplasia", "30", "mentally", "retarded", "epileptic", "children", "treated", "with", "C0031507#ent", "<e2>", "."], "h": {"id": "C0017574", "name": "C0017574#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [35, 36]}}
{"token": ["Hereditary", "hemorrhagic", "telangiectasia", "C0062941#ent", "<e1>", ")", "or", "Osler-Weber-Rendu", "syndrome", "an", "C2936739#ent", "<e2>", "vascular", "disorder", "by", "telangiectases", "and", "internal", "arteriovenous", "malformations"], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [10, 11]}}
{"token": ["Most", "statins", "are", "metabolised", "by", "the", "C1142644#ent", "<e1>", "izoenzyme", "(", "lovastatin", ",", "C0074554#ent", "<e2>", ",", "atorvastatin", ",", "cerivastatin", ")", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [6, 7]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0074554", "name": "C0074554#ent", "pos": [12, 13]}}
{"token": ["Further", "characterization", "of", "rat", "urine", "VPDPR-LI", "revealed", "that", "it", "is", "not", "due", "to", "C0664116#ent", "<e1>", "but", "to", "another", "C0030956#ent", "<e2>", "similar", "to", "C0664116#ent", "<e1>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0664116", "name": "C0664116#ent", "pos": [13, 14]}}
{"token": ["On", "further", "characterization", ",", "brain", "VPDPR-LI", "was", "shown", "not", "to", "be", "due", "to", "APGPR", ",", "VPGPR", ",", "or", "C0664116#ent", "<e1>", "but", "to", "another", "C0030956#ent", "<e2>", "with", "an", "epitope", "similar", "to", "C0664116#ent", "<e1>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0664116", "name": "C0664116#ent", "pos": [18, 19]}}
{"token": ["Because", "studies", "in", "cells", "other", "than", "cardiomyocytes", "revealed", "that", "C3831543#ent", "<e1>", "AMPK", ")", "and", "C0164786#ent", "<e2>", "are", "affected", "by", "resveratrol", ",", "we", "hypothesized", "that", "resveratrol", "prevents", "cardiac", "myocyte", "hypertrophy", "these", "two", "kinase", "systems", "."], "h": {"id": "C3831543", "name": "C3831543#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [14, 15]}}
{"token": ["Two", "recently", "developed", "antiepileptic", "drugs", "AEDs", ")", ",", "vigabatrin", "(", "VGB", ")", "and", "tiagabine", "(", "C1335239#ent", "<e1>", ")", ",", "are", "examples", "of", "such", "C0991617#ent", "<e2>", "."], "h": {"id": "C1335239", "name": "C1335239#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [23, 24]}}
{"token": ["Presence", "of", "AS", "or", "AC", "had", "no", "detectable", "influence", "on", "C1336050#ent", "<e1>", "osteoarthritis", "of", "the", "knee", ",", "tendinitis", "or", "C0033581#ent", "<e2>"], "h": {"id": "C1336050", "name": "C1336050#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [19, 20]}}
{"token": ["The", "infections", "diagnosed", "were", "C0008677#ent", "<e1>", "5", "patients", ",", "diffuse", "panbronchiolitis", "2", "and", "C0006285#ent", "<e2>", "in", "2", "."], "h": {"id": "C0008677", "name": "C0008677#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006285", "name": "C0006285#ent", "pos": [13, 14]}}
{"token": ["The", "histopathological", "features", "bear", "a", "striking", "resemblance", "to", "those", "seen", "in", "postencephalitic", "parkinsonism", "C0014040#ent", "<e1>", "and", "in", "the", "parkinsonism-dementia", "complex", "of", "Guam", "(", "C1335199#ent", "<e2>", ")", "."], "h": {"id": "C0014040", "name": "C0014040#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1335199", "name": "C1335199#ent", "pos": [23, 24]}}
{"token": ["Activation", "of", "these", "receptors", "stimulated", "a", "Ca2", "+", "-dependent", "and", "a", "Ca2", "+", "-independent", "C3539768#ent", "<e1>", "the", "latter", "resulting", "in", "C1416669#ent", "<e2>", "secretion", "."], "h": {"id": "C3539768", "name": "C3539768#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1416669", "name": "C1416669#ent", "pos": [20, 21]}}
{"token": ["Intralobar", "administration", "of", "the", "selective", "alpha-1", "adrenoceptor", "C0025681#ent", "<e1>", "and", "the", "selective", "C2746076#ent", "<e2>", "elicited", "dose-dependent", "increases", "in", "lobar", "perfusion", "pressure", ",", "as", "did", "the", "nonselective", "alpha", "adrenoceptor", "norepinephrine", "."], "h": {"id": "C0025681", "name": "C0025681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2746076", "name": "C2746076#ent", "pos": [12, 13]}}
{"token": ["Alpha-1", "adrenergic", "agonists", "cirazoline", ",", "C0025681#ent", "<e1>", ",", "and", "phenylephrine", ")", "were", "stimulatory", "whereas", "C2746076#ent", "<e2>", "high", "doses", "tramazoline", ",", "BHT-920", ",", "xylazine", ",", "and", "UK-14304", ")", "were", "without", "effect", "."], "h": {"id": "C0025681", "name": "C0025681#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2746076", "name": "C2746076#ent", "pos": [14, 15]}}
{"token": ["It", "is", "concluded", "that", "10", "and", "20", "mg", "C0058895#ent", "<e1>", "were", "free", "from", "C0036557#ent", "<e2>", "adverse", "effects"], "h": {"id": "C0058895", "name": "C0058895#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036557", "name": "C0036557#ent", "pos": [13, 14]}}
{"token": ["C0030956#ent", "<e1>", "containing", "either", "SA1", "or", "C1420449#ent", "<e2>", "interact", "efficiently", "with", "the", "full-length", "phragmoplastin", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420449", "name": "C1420449#ent", "pos": [6, 7]}}
{"token": ["Thyroliberin", "E-H-P-NH2", "(", "C1705225#ent", "<e1>", ")", "is", "a", "C1334960#ent", "<e2>", "widely", "distributed", "in", "neural", "sites"], "h": {"id": "C1705225", "name": "C1705225#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334960", "name": "C1334960#ent", "pos": [8, 9]}}
{"token": ["It", "also", "highlights", "possible", "complications", "of", "C1704275#ent", "<e1>", "including", "the", "rare", "but", "serious", "complication", "of", "C0009492#ent", "<e2>"], "h": {"id": "C1704275", "name": "C1704275#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009492", "name": "C0009492#ent", "pos": [15, 16]}}
{"token": ["Normal", "glucagon", "suppression", "was", "observed", "in", "the", "lean", "controls", "C2985244#ent", "<e1>", "but", "not", "in", "OR", ",", "O-IGT", ",", "and", "C0011854#ent", "<e2>", "."], "h": {"id": "C2985244", "name": "C2985244#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [19, 20]}}
{"token": ["The", "differential", "diagnosis", "be", "placed", "with", ":", "peptic", "ulcer", "C0001339#ent", "<e1>", "acute", "appendicitis", "gonococcus", "perihepatitis", ",", "virus", "hepatitis", "C0859681#ent", "<e2>", "right", "basal", "pneumonia"], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0859681", "name": "C0859681#ent", "pos": [18, 19]}}
{"token": ["Eight", "patients", "were", "judged", "improved", ";", "two", "had", "Huntington's", "chorea", "two", "athetosis", ",", "two", "dystonia", "musculorum", "deformans", "one", "C0221169#ent", "<e1>", ",", "and", "one", "C0152116#ent", "<e2>"], "h": {"id": "C0221169", "name": "C0221169#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0152116", "name": "C0152116#ent", "pos": [23, 24]}}
{"token": ["Cholinephosphotransferase", "required", "C0001477#ent", "<e1>", "was", "inhibited", "by", "Ca2", "+", ",", "while", "C0001068#ent", "<e2>", "required", "the", "presence", "of", "NaF", "(", "a", "phosphatase", "inhibitor", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001068", "name": "C0001068#ent", "pos": [11, 12]}}
{"token": ["By", "electrophysiological", "recordings", "ex", "vivo", "we", "found", "that", "C0751039#ent", "<e1>", "counteracted", "the", "decrease", "in", "chloride", "conductance", "(", "C0023521#ent", "<e2>", ")", ",", "a", "functional", "index", "degeneration", "in", "diaphragm", "and", "extensor", "digitorum", "longus", "muscle", "fibers"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023521", "name": "C0023521#ent", "pos": [17, 18]}}
{"token": ["There", "was", "no", "difference", "in", "serum", "antibody", "to", "C1704715#ent", "<e1>", "in", "the", "two", "groups", "with", "C3714496#ent", "<e2>", "."], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714496", "name": "C3714496#ent", "pos": [15, 16]}}
{"token": ["Nevertheless", ",", "cigarette", "smoking", "to", "be", "a", "risk", "factor", "mortality", "after", "C0027051#ent", "<e1>", "even", "for", "those", "receiving", "C0033497#ent", "<e2>", "."], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [17, 18]}}
{"token": ["Here", "the", "interaction", "of", "the", "C3813543#ent", "<e1>", "with", "synthetic", "peptides", "of", "15", "-", "36", "C3539946#ent", "<e2>", "corresponding", "to", "different", "parts", "of", "the", "gp120", "envelope", "protein", "described", "."], "h": {"id": "C3813543", "name": "C3813543#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [14, 15]}}
{"token": ["C0085113#ent", "<e1>", "and", "p120", "GTPase", "activating", "protein", "(", "p120", "C1419277#ent", "<e2>", ")", "down-regulate", "the", "activity", "of", "cellular", "Ras", "proteins"], "h": {"id": "C0085113", "name": "C0085113#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419277", "name": "C1419277#ent", "pos": [9, 10]}}
{"token": ["The", "fluorescent", "antibody", "neutralization", "(", "C0015683#ent", "<e1>", ")", "test", "for", "the", "detection", "of", "antibodies", "to", "C0019841#ent", "<e2>", "developed", "utilizing", "96-well", "and", "Terasaki", "microplates", "."], "h": {"id": "C0015683", "name": "C0015683#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019841", "name": "C0019841#ent", "pos": [15, 16]}}
{"token": ["The", "most", "common", "causes", "were", "C0041912#ent", "<e1>", "sinusitis", ",", "otomastoiditis", ",", "C0024205#ent", "<e2>", "and", "retropharyngeal", "abscess", "cellulitis", "."], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024205", "name": "C0024205#ent", "pos": [11, 12]}}
{"token": ["To", "investigate", "the", "prevalence", "of", "C1417104#ent", "<e1>", "gene", "mutations", "Turkish", "patients", "with", "C2721603#ent", "<e2>", "HSP", ")", "but", "with", "no", "symptoms", "of", "familial", "Mediterranean", "fever", "FMF", ")", "."], "h": {"id": "C1417104", "name": "C1417104#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2721603", "name": "C2721603#ent", "pos": [12, 13]}}
{"token": ["Twenty-three", "of", "30", "patients", "were", "treated", "with", "recombinant", "tissue-type", "plasminogen", "activator", "C0032143#ent", "<e1>", ")", "within", "4", "hours", "after", "onset", "of", "C0008031#ent", "<e2>"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008031", "name": "C0008031#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "synthetic", "IDA", "and", "IDL1", "C3810537#ent", "<e1>", "peptides", "rescued", "C3889248#ent", "<e2>", "and", "induced", "early", "floral", "abscission", "wild-type", "flowers", "."], "h": {"id": "C3810537", "name": "C3810537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889248", "name": "C3889248#ent", "pos": [11, 12]}}
{"token": ["Phosphatidylinositol", "(", "PI", ")", "3-kinase", ",", "a", "critical", "signaling", "C0014442#ent", "<e1>", "that", "modulates", "HASM", "cell", "growth", ",", "is", "preferentially", "associated", "with", "C0242957#ent", "<e2>", ",", "and", "EGF-stimulated", "transactivation", "of", "C0242957#ent", "<e2>", "induces", "PI", "3-kinase", "activation", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [21, 22]}}
{"token": ["C0142805#ent", "<e1>", "been", "recommended", "for", "the", "treatment", "of", "C0220994#ent", "<e2>", "in", "humans", "."], "h": {"id": "C0142805", "name": "C0142805#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0220994", "name": "C0220994#ent", "pos": [8, 9]}}
{"token": ["Supplementation", "with", "carnitine", "may", "be", "necessary", "to", "minimise", "the", "adverse", "effects", "C0142805#ent", "<e1>", "treatment", "in", "C0220994#ent", "<e2>", "."], "h": {"id": "C0142805", "name": "C0142805#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0220994", "name": "C0220994#ent", "pos": [15, 16]}}
{"token": ["One", "eye", "with", "C0154822#ent", "<e1>", "retinal", "breaks", "the", "coloboma", "had", "been", "having", "C0035305#ent", "<e2>", "localized", "in", "the", "nasal", "area", "to", "the", "optic", "nerve", "head"], "h": {"id": "C0154822", "name": "C0154822#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0035305", "name": "C0035305#ent", "pos": [12, 13]}}
{"token": ["Strategies", "for", "treatment", "with", "oral", "C0020616#ent", "<e1>", ":", "Targeting", "fasting", "C0020456#ent", "<e2>", ",", "targeting", "postprandial", "C0020456#ent", "<e2>", ",", "minimising", "cost", "therapy", "minimising", "weight", "gain", "minimising", "patient", "effort", "strategies", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [10, 11]}}
{"token": ["MRP3", ",", "like", "C3539701#ent", "<e1>", ",", "is", "mainly", "expressed", "in", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C3539701", "name": "C3539701#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}}
{"token": ["In", "immunoblot", "analysis", "crude", "membranes", "of", "various", "rabbit", "tissues", ",", "C3539701#ent", "<e1>", "was", "only", "found", "in", "small", "intestine", "kidney", "and", "C0023899#ent", "<e2>", "."], "h": {"id": "C3539701", "name": "C3539701#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [20, 21]}}
{"token": ["C1417827#ent", "<e1>", "contained", "sufficient", "exocytosable", "C1313497#ent", "<e2>", "kill", "at", "about", "80", "%", "of", "the", "rate", "possible", "at", "infinite", "exocytosable", "granzyme", "A."], "h": {"id": "C1417827", "name": "C1417827#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1313497", "name": "C1313497#ent", "pos": [5, 6]}}
{"token": ["C1366499#ent", "<e1>", "NEP", ")", "is", "a", "C0052527#ent", "<e2>", "a", "ubiquitous", "expression", "and", "is", "capable", "of", "degrading", "a", "number", "of", "bioactive", "peptides", "including", "ET-1", "."], "h": {"id": "C1366499", "name": "C1366499#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0052527", "name": "C0052527#ent", "pos": [6, 7]}}
{"token": ["C0242957#ent", "<e1>", "overexpression", "has", "been", "associated", "with", "C1366459#ent", "<e2>", "human", "breast", "cancer", "and", "it", "has", "been", "suggested", "that", "the", "combined", "treatment", "of", "an", "anti-HER2", "antibody", "tamoxifen", "has", "enhanced", "anti-cancer", "efficacy", "breast", "cancer"], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366459", "name": "C1366459#ent", "pos": [7, 8]}}
{"token": ["This", "residue", "is", "located", "in", "alpha-Helix", "III", "the", "C1823282#ent", "<e1>", "of", "the", "P", "domain", "the", "C1416829#ent", "<e2>", "tertiary", "structure", "removed", "from", "the", "substrate-binding", "cleft", "between", "the", "P", "and", "Q", "domains"], "h": {"id": "C1823282", "name": "C1823282#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416829", "name": "C1416829#ent", "pos": [15, 16]}}
{"token": ["DWI", "discriminates", "MSA-P", "from", "C1332754#ent", "<e1>", "and", "Parkinson's", "disease", "healthy", "volunteers", "the", "basis", "of", "C4283801#ent", "<e2>", "rADC", "values", "."], "h": {"id": "C1332754", "name": "C1332754#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [14, 15]}}
{"token": ["Gene", "therapy", "a", "promising", "modality", "for", "the", "treatment", "of", "various", "cardiovascular", "diseases", "as", "ischaemia", ",", "C0018802#ent", "<e1>", "restenosis", "after", "revascularisation", ",", "hypertension", "and", "C0020480#ent", "<e2>", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020480", "name": "C0020480#ent", "pos": [23, 24]}}
{"token": ["Bromocriptine", "was", "ten", "times", "more", "potent", "and", "pramipexole", "and", "C0244821#ent", "<e1>", "ten", "times", "less", "potent", "at", "the", "dopamine", "D2", "at", "the", "C1414148#ent", "<e2>", "whereas", "pergolide", "was", "equipotent", "at", "the", "two", "receptors", "."], "h": {"id": "C0244821", "name": "C0244821#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414148", "name": "C1414148#ent", "pos": [21, 22]}}
{"token": ["CGIs", "showing", "C1420295#ent", "<e1>", "methylation", "were", "overrepresented", "at", "numerous", "C0678933#ent", "<e2>", "are", "essential", "for", "development", ",", "including", "HOX", "and", "PAX", "family", "members"], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0678933", "name": "C0678933#ent", "pos": [9, 10]}}
{"token": ["Only", "CDs", "that", "lowered", "cholesterol", "levels", "redistributed", "the", "NMDA", "receptor", "NR2B", "subunit", ",", "PSD-95", "(", "C1333226#ent", "<e1>", "and", "neuronal", "nitric", "oxide", "synthase", "nNOS", ")", "from", "C0146951#ent", "<e2>", "insoluble", "membrane", "domains", "soluble", "fractions", "."], "h": {"id": "C1333226", "name": "C1333226#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [25, 26]}}
{"token": ["We", "used", "the", "technique", "of", "RNA", "interference", "to", "inhibit", "the", "mRNA", "encoding", "the", "C0027203#ent", "<e1>", "responsible", "for", "1,25D", "synthesis", ",", "C1413865#ent", "<e2>", "CYP27B1", ")", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413865", "name": "C1413865#ent", "pos": [20, 21]}}
{"token": ["Transfection", "of", "endothelial", "cells", "an", "oligonucleotide", "that", "decreases", "C2825936#ent", "<e1>", "permits", "an", "increase", "in", "C1710304#ent", "<e2>", "VCAM-1", "expression", "."], "h": {"id": "C2825936", "name": "C2825936#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "characterize", "BEC", "plasma", "C1413052#ent", "<e1>", "by", "patients", "'", "autoantibodies", "in", "C0008312#ent", "<e2>", "."], "h": {"id": "C1413052", "name": "C1413052#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [17, 18]}}
{"token": ["Use", "of", "BEC", "purified", "from", "human", "liver", "may", "help", "in", "deciphering", "the", "possible", "importance", "of", "BEC", "plasma", "C1413052#ent", "<e1>", "immune", "recognition", "toxicity", "toward", "BEC", "in", "C0008312#ent", "<e2>", "."], "h": {"id": "C1413052", "name": "C1413052#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [25, 26]}}
{"token": ["The", "effect", "of", "C1705027#ent", "<e1>", ":", "Max", "was", "sensitive", "to", "Trichostatin", "A", "indicating", "involvement", "of", "C0019643#ent", "<e2>", "activity", "in", "repression", "of", "the", "Ndr1", "promoter", "."], "h": {"id": "C1705027", "name": "C1705027#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [15, 16]}}
{"token": ["C0218076#ent", "<e1>", "did", "not", "inhibit", "the", "steroid", "synthetic", "enzymes", "including", "3beta-hydroxysteroid", "C0030016#ent", "<e2>", ",", "21-hydroxylase", ",", "11beta-hydroxylase", ",", "or", "cholesterol", "side-chain", "cleavage", "enzymes", "."], "h": {"id": "C0218076", "name": "C0218076#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [11, 12]}}
{"token": ["Additional", "C3274826#ent", "<e1>", "experiments", "revealed", "that", "the", "third", "C0633225#ent", "<e2>", "signal", "was", "the", "result", "of", "a", "third", "copy", "of", "the", "gene", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0633225", "name": "C0633225#ent", "pos": [8, 9]}}
{"token": ["The", "induction", "of", "C1706331#ent", "<e1>", "was", "significantly", "down-regulated", "in", "response", "to", "the", "C2936569#ent", "<e2>", "was", "inhibited", "by", "cycloheximide", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936569", "name": "C2936569#ent", "pos": [12, 13]}}
{"token": ["In", "case", "of", "C0021251#ent", "<e1>", "specific", "changes", "between", "C1565830#ent", "<e2>", "and", "COX-2", "were", "noted", "in", "helix", "D", "H6", ",", "S6", "and", "helix", "H8", "in", "the", "cyclooxygenase", "cavity"], "h": {"id": "C0021251", "name": "C0021251#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [8, 9]}}
{"token": ["We", "have", "applied", "computer", "simulation", "technique", "study", "interaction", "of", "two", "anti-inflammatory", "drugs", "NSAIDs", ")", "C0021251#ent", "<e1>", "and", "NS398", "with", "cyclooxygenase", "(", "C1565830#ent", "<e2>", "and", "COX-2", ")", "enzymes", "."], "h": {"id": "C0021251", "name": "C0021251#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [21, 22]}}
{"token": ["C0023835#ent", "<e1>", "catalyzes", "the", "oxidation", "of", "DES", "to", "its", "corresponding", "DES", "C1096793#ent", "<e2>", "to", "yield", "free", "radical", "species", "intermediates", "(", "DES", "semiquinone", "and", "DES", "quinone", ",", "which", "are", "associated", "with", "adverse", "effects", "this", "synthetic", "estrogen"], "h": {"id": "C0023835", "name": "C0023835#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1096793", "name": "C1096793#ent", "pos": [11, 12]}}
{"token": ["C0235025#ent", "<e1>", "be", "closely", "related", "to", "C0011884#ent", "<e2>"], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [6, 7]}}
{"token": ["Moreover", ",", "partial", "C1538830#ent", "<e1>", "activity", "could", "be", "reconstituted", "in", "vivo", "two", "non-covalently", "linked", ",", "complementary", "C1305923#ent", "<e2>", "that", "represent", "the", "two", "functional", "modules", "of", "C1538830#ent", "<e1>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1538830", "name": "C1538830#ent", "pos": [3, 4]}}
{"token": ["Wild", "type", "ROMK1", ",", "[S44A]ROMK1", ",", "and", "[S44D]ROMK1", "were", "expressed", "in", "Xenopus", "oocytes", "or", "without", "C0669365#ent", "<e1>", "active", "[S422D]SGK1", "and", "C1420237#ent", "<e2>", ",", "and", "K(+", ")", "current", "(", "I(KR", ")", ")", "determined", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420237", "name": "C1420237#ent", "pos": [20, 21]}}
{"token": ["Polycomb", "group", "proteins", "HPC2", "and", "BMI-1", "and", "the", "C1332799#ent", "<e1>", "bind", "the", "C0919528#ent", "<e2>", "repression", "domain", "."], "h": {"id": "C1332799", "name": "C1332799#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0919528", "name": "C0919528#ent", "pos": [12, 13]}}
{"token": ["Patients", "who", "experience", "postoperative", "C0007787#ent", "<e1>", "or", "stroke", "usually", "have", "underlying", "C0029896#ent", "<e2>", "without", "resolution", "or", "good", "control"], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["Mannan-binding", "lectin", "MBL", ",", "previously", "named", "C2347054#ent", "<e1>", "MBP", ")", "is", "a", "C1417054#ent", "<e2>", "which", "activates", "complement", "upon", "binding", "to", "microbial", "carbohydrates", "."], "h": {"id": "C2347054", "name": "C2347054#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417054", "name": "C1417054#ent", "pos": [12, 13]}}
{"token": ["A", "considerable", "increase", "in", "breath", "hydrogen", "C0067320#ent", "<e1>", "appeared", "after", "sorbitol", "and", "C0022957#ent", "<e2>", ",", "but", "not", "after", "glucose", "."], "h": {"id": "C0067320", "name": "C0067320#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022957", "name": "C0022957#ent", "pos": [12, 13]}}
{"token": ["Recent", "studies", "have", "shown", "reduced", "breath", "hydrogen", "H2", ")", "excretion", "in", "C0067320#ent", "<e1>", "(CH4)-producing", "healthy", "individuals", "following", "ingestion", "of", "C0022957#ent", "<e2>", "."], "h": {"id": "C0067320", "name": "C0067320#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022957", "name": "C0022957#ent", "pos": [19, 20]}}
{"token": ["A", "92-year-old", "woman", "presented", "with", "severe", "C2243087#ent", "<e1>", "to", "abuse", "of", "C0003211#ent", "<e2>", "NSAIDs", ")", "."], "h": {"id": "C2243087", "name": "C2243087#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [11, 12]}}
{"token": ["A", "92-year-old", "woman", "presented", "with", "severe", "C2243087#ent", "<e1>", "to", "abuse", "of", "non-steroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e2>", ")", "."], "h": {"id": "C2243087", "name": "C2243087#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [14, 15]}}
{"token": ["Downstream", "of", "the", "PKC", "the", "functionality", "of", "C0139030#ent", "<e1>", "a", "prerequisite", "for", "LHBs-dependent", "activation", "of", "C0162508#ent", "<e2>", "and", "NF-kappa", "B", "inhibition", "of", "C0139030#ent", "<e1>", "LHBs-dependent", "transcriptional", "activation", "of", "C0162508#ent", "<e2>", "and", "NF-kappa", "B."], "h": {"id": "C0139030", "name": "C0139030#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [15, 16]}}
{"token": ["Patients", "with", "RA", "appear", "to", "have", "less", "capacity", "for", "excreting", "C0000970#ent", "<e1>", "as", "C0221777#ent", "<e2>", "conjugates", "and", "may", "be", "more", "susceptible", "to", "C0000970#ent", "<e1>", "toxicity", ",", "especially", "on", "chronic", "dosage", "."], "h": {"id": "C0221777", "name": "C0221777#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [10, 11]}}
{"token": ["Cytomegalovirus", "pneumonia", "C1535939#ent", "<e1>", "and", "pulmonary", "and", "C0004032#ent", "<e2>", "simultaneously", "in", "a", "66-year-old", "white", "man", "oat", "cell", "carcinoma", "ectopic", "corticotropin", "production", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004032", "name": "C0004032#ent", "pos": [7, 8]}}
{"token": ["The", "Km", "for", "3'-", "or", "5'-AMP", "increases", "in", "the", "C1332788#ent", "<e1>", "whole", "cells", "used", "as", "the", "C0027203#ent", "<e2>", "source", "."], "h": {"id": "C1332788", "name": "C1332788#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}}
{"token": ["Subjects", "comprised", "120", "healthy", "volunteers", "20", "patients", "with", "C0016977#ent", "<e1>", "acute", "cystitis", "bladder", "stones", "12", "patients", "with", "C1561643#ent", "<e2>", "and", "117", "patients", "with", "histologically", "confirmed", "primary", "bladder", "cancer"], "h": {"id": "C0016977", "name": "C0016977#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [17, 18]}}
{"token": ["Patients", "with", "C0034069#ent", "<e1>", "have", "a", "poorer", "prognosis", "than", "those", "with", "C1290344#ent", "<e2>", "and", "most", "other", "IIPs", "."], "h": {"id": "C0034069", "name": "C0034069#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1290344", "name": "C1290344#ent", "pos": [11, 12]}}
{"token": ["Previous", "studies", "on", "neutrophils", "in", "patients", "with", "the", "myelodysplastic", "syndromes", "C0265219#ent", "<e1>", ")", "have", "indicated", "C0268487#ent", "<e2>", "in", "the", "contents", "of", "primary", "and", "secondary", "granules"], "h": {"id": "C0265219", "name": "C0265219#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [15, 16]}}
{"token": ["In", "order", "of", "C0242912#ent", "<e1>", "the", "agents", "ranked", "as", "follows", ":", "C0058903#ent", "<e2>", ">", "carvedilol", ">"], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0058903", "name": "C0058903#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "several", "C0017337#ent", "<e1>", "in", "this", "pathway", ",", "including", "APAF1", ",", "C1332668#ent", "<e2>", "and", "CASP3", ",", "have", "been", "shown", "to", "be", "associated", "with", "defects", "in", "neuronal", "cell", "number", "brain", "size", "mutated", "in", "mice", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332668", "name": "C1332668#ent", "pos": [12, 13]}}
{"token": ["The", "ion", "transporters", "are", "Na(+)/H(+)", "exchanger", "3", "C1420234#ent", "<e1>", ")", "and", "the", "down", "regulated", "in", "adenoma", "(", "C1335836#ent", "<e2>", ")", "gene", "product"], "h": {"id": "C1420234", "name": "C1420234#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335836", "name": "C1335836#ent", "pos": [17, 18]}}
{"token": ["A", "strong", "multigene", "signature", "of", "an", "epithelial", "to", "mesenchymal", "transition", "C1420138#ent", "<e1>", ")", "was", "identified", "as", "a", "determinant", "of", "insensitivity", "to", "C1135135#ent", "<e2>", "through", "both", "supervised", "and", "unsupervised", "gene", "expression", "approaches", "."], "h": {"id": "C1420138", "name": "C1420138#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1135135", "name": "C1135135#ent", "pos": [21, 22]}}
{"token": ["CBM-EndoF1", "is", "as", "effective", "as", "native", "EndoF1", "at", "deglycosylating", "C3815268#ent", "<e1>", ";", "the", "glycans", "released", "by", "both", "C0014442#ent", "<e2>", "are", "identical", "."], "h": {"id": "C3815268", "name": "C3815268#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [17, 18]}}
{"token": ["Most", "had", "C3714552#ent", "<e1>", "the", "accompanying", "C0018989#ent", "<e2>", "was", "of", "variable", "severity", "."], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018989", "name": "C0018989#ent", "pos": [6, 7]}}
{"token": ["So", "far", ",", "C0063041#ent", "<e1>", "has", "not", "been", "associated", "with", "severe", "bone", "marrow", "toxicity", "and", "C0030312#ent", "<e2>", "."], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030312", "name": "C0030312#ent", "pos": [15, 16]}}
{"token": ["Malignant", "neoplasms", "especially", "of", "the", "stomach", ",", "lung", "and", "C0771711#ent", "<e1>", ",", "show", "a", "trend", "to", "increase", ",", "and", "C0007820#ent", "<e2>", "liver", "cirrhosis", "a", "trend", "to", "decrease", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [19, 20]}}
{"token": ["Pharmacokinetic", "interactions", "C0072916#ent", "<e1>", "involve", "inhibition", "of", "cytochrome", "P450", "CYP", ")", "C1142644#ent", "<e2>", ",", "the", "primary", "mode", "elimination", "of", "C0072916#ent", "<e1>", ",", "thereby", "increasing", "plasma", "concentrations", "of", "the", "drug", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [2, 3]}}
{"token": ["The", "macrolide", "antibacterials", "clarithromycin", ",", "erythromycin", "and", "troleandomycin", "are", "inhibitors", "of", "C1142644#ent", "<e1>", "and", "should", "not", "be", "used", "in", "conjunction", "with", "C0072916#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [21, 22]}}
{"token": ["Despite", "these", "results", ",", "the", "possibility", "existed", "that", "clavaric", "acid", "inhibited", "C0525678#ent", "<e1>", "processing", "by", "directly", "inhibiting", "C0063164#ent", "<e2>"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0063164", "name": "C0063164#ent", "pos": [17, 18]}}
{"token": ["Randomized", ",", "double-blind", "trials", "shown", "posaconazole", "to", "be", "at", "least", "as", "efficacious", "as", "C0016277#ent", "<e1>", "for", "the", "prevention", "of", "invasive", "C0026946#ent", "<e2>", "immunocompromised", "patients", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [20, 21]}}
{"token": ["We", "conclude", "that", "C0004235#ent", "<e1>", "may", "be", "used", "in", "patients", "with", "severe", "C0023895#ent", "<e2>"], "h": {"id": "C0004235", "name": "C0004235#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [12, 13]}}
{"token": ["The", "C0242889#ent", "<e1>", "phentermine", ",", "diethylpropion", ",", "mazindol", ",", "benzphetamine", ",", "and", "C0070549#ent", "<e2>", "are", "approved", "only", "for", "short-term", "use", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0070549", "name": "C0070549#ent", "pos": [12, 13]}}
{"token": ["We", "examined", "the", "modulation", "of", "C1705470#ent", "<e1>", "expression", "by", "HuIFN-beta", "in", "UV-sensitive", "cells", "C0009207#ent", "<e2>", "B", "(", "CSB", ")", ",", "xeroderma", "pigmentosum", "complementation", "A", "XPA", ")", "and", "normal", "control", "cells", "."], "h": {"id": "C1705470", "name": "C1705470#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [13, 14]}}
{"token": ["By", "reporting", "this", "case", ",", "we", "hope", "to", "increase", "the", "awareness", "of", "obstetricians", "to", "the", "possibility", "of", "C0025281#ent", "<e1>", "patients", "present", "with", "signs", "of", "unabating", "oropharyngeal", "infection", "C1457887#ent", "<e2>"], "h": {"id": "C0025281", "name": "C0025281#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [27, 28]}}
{"token": ["These", "functions", "of", "C3853886#ent", "<e1>", "initially", "appear", "contradictory", ",", "since", "increased", "C1414805#ent", "<e2>", "Complex1", "activation", "is", "triggered", "by", "increased", "amino", "acid", "levels", ",", "while", "autophagy", "is", "triggered", "when", "cells", "are", "faced", "with", "amino", "acid", "deprivation"], "h": {"id": "C3853886", "name": "C3853886#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414805", "name": "C1414805#ent", "pos": [11, 12]}}
{"token": ["We", "determined", "the", "characteristics", "and", "clinical", "course", "hospitalized", "patients", "experiencing", "C1854562#ent", "<e1>", "as", "well", "as", "their", "risk", "of", "developing", "subsequent", "C1413662#ent", "<e2>", "."], "h": {"id": "C1854562", "name": "C1854562#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413662", "name": "C1413662#ent", "pos": [20, 21]}}
{"token": ["We", "suggest", "that", "the", "observed", "C1667078#ent", "<e1>", "diversification", "contributes", "to", "differential", "host", "infection", "C1537624#ent", "<e2>", "and", "II", "genotypes"], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1537624", "name": "C1537624#ent", "pos": [13, 14]}}
{"token": ["This", "suggests", "the", "CYP3A4", "C0597298#ent", "<e1>", "is", "involved", "in", "the", "metabolism", "of", "C0074676#ent", "<e2>", ",", "in", "vivo"], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0074676", "name": "C0074676#ent", "pos": [12, 13]}}
{"token": ["On", "average", ",", "the", "patients", "rated", "the", "pain", "as", "being", "less", "than", "C0013456#ent", "<e1>", "or", "toothache", ",", "but", "more", "than", "C0270697#ent", "<e2>", "or", "bachache", "."], "h": {"id": "C0013456", "name": "C0013456#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [20, 21]}}
{"token": ["We", "examined", "the", "correlation", "of", "mutations", "in", "the", "pyrazinamidase", "(", "PZase", ")", "gene", "(", "pncA", ")", "with", "the", "C0034239#ent", "<e1>", "(", "PZA", ")", "resistance", "phenotype", "with", "60", "Mycobacterium", "tuberculosis", "C1875400#ent", "<e2>", "."], "h": {"id": "C0034239", "name": "C0034239#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [29, 30]}}
{"token": ["The", "goal", "of", "this", "study", "was", "to", "apply", "temperature-mediated", "heteroduplex", "analysis", "denaturing", "high-performance", "liquid", "chromatography", "identify", "C0034239#ent", "<e1>", "(", "PZA", ")", "resistance", "in", "Mycobacterium", "tuberculosis", "C1875400#ent", "<e2>", "and", "simultaneously", "differentiate", "between", "M.", "tuberculosis", "Mycobacterium", "bovis"], "h": {"id": "C0034239", "name": "C0034239#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [25, 26]}}
{"token": ["Consistent", "with", "gene", "expression", "profile", "DNA", "binding", "activity", "C0079068#ent", "<e1>", "and", "the", "nuclear", "protein", "concentration", "of", "its", "coactivator", ",", "upstream", "binding", "factor", "C1421307#ent", "<e2>", ")", ",", "increased", "in", "the", "atrophied", "heart", "whereas", "protein", "levels", "the", "C0079068#ent", "<e1>", "inhibitor", "MAD1", "decreased", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421307", "name": "C1421307#ent", "pos": [22, 23]}}
{"token": ["The", "impact", "of", "two", "calcium", "channel", "blockers", "different", "structure", ",", "C0012373#ent", "<e1>", "and", "felodipine", ",", "on", "C1705340#ent", "<e2>", "secretion", "was", "studied", "under", "hyper-", "and", "hypocalcemic", "conditions", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [16, 17]}}
{"token": ["In", "order", "to", "understand", "the", "importance", "of", "the", "hydantoin", "ring", "good", "sodium", "channel", "binding", "related", "C0020209#ent", "<e1>", "such", "as", "hydroxy", "amides", "C0304361#ent", "<e2>", ",", "hydroxy", "acids", "and", "amino", "acids", "included", "."], "h": {"id": "C0020209", "name": "C0020209#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0304361", "name": "C0304361#ent", "pos": [21, 22]}}
{"token": ["We", "report", "the", "cloning", "of", "a", "C0079429#ent", "<e1>", ",", "intronless", "in", "its", "coding", "region", "which", "we", "have", "named", "C1412289#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412289", "name": "C1412289#ent", "pos": [18, 19]}}
{"token": ["Overexpression", "of", "C1537839#ent", "<e1>", "leads", "to", "repression", "of", "endogenous", "C1423021#ent", "<e2>", ",", "and", "inhibition", "of", "C1537839#ent", "<e1>", "relieves", "the", "repression", "of", "C1423021#ent", "<e2>", "."], "h": {"id": "C1423021", "name": "C1423021#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1537839", "name": "C1537839#ent", "pos": [2, 3]}}
{"token": ["One", "of", "the", "recent", "breakthrough", "studies", "in", "C3539732#ent", "<e1>", "signaling", "resulted", "in", "the", "identification", "of", "the", "tuberous", "sclerosis", "complex", "gene", "products", "C1706236#ent", "<e2>", "and", "TSC2", ",", "as", "negative", "regulators", "C3539732#ent", "<e1>", "signaling", "."], "h": {"id": "C1706236", "name": "C1706236#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3539732", "name": "C3539732#ent", "pos": [7, 8]}}
{"token": ["C1706236#ent", "<e1>", "and", "TSC2", "may", "antagonize", "C3539732#ent", "<e2>", "signaling", "in", "mammalian", "cells", "Drosophila", "."], "h": {"id": "C1706236", "name": "C1706236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539732", "name": "C3539732#ent", "pos": [6, 7]}}
{"token": ["A", "retrospective", "study", "67", "human", "breast", "carcinomas", "various", "types", "and", "grades", "was", "conducted", "using", "the", "avidin-biotin-peroxidase", "complex", "ABC", ")", "to", "localize", "C0007332#ent", "<e1>", ",", "lactalbumin", ",", "and", "C1418587#ent", "<e2>", "70", "on", "paraffin", "sections"], "h": {"id": "C0007332", "name": "C0007332#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1418587", "name": "C1418587#ent", "pos": [27, 28]}}
{"token": ["Reduced", "or", "absent", "anal", "tone", ",", "C0013428#ent", "<e1>", ",", "absence", "of", "pupillary", "light", "reflexes", "intact", "vision", ",", "C0026961#ent", "<e2>", ",", "decreased", "corneal", "sensitivity", "and", "nictitating", "membrane", "protrusion", "among", "the", "most", "frequent", "neurological", "findings"], "h": {"id": "C0013428", "name": "C0013428#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026961", "name": "C0026961#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "show", "that", "C1420466#ent", "<e1>", "(", "AurA", ")", "acts", "as", "a", "tumor", "suppressor", "suppressing", "C0919442#ent", "<e2>", "self-renewal", "and", "promoting", "neuronal", "differentiation"], "h": {"id": "C1420466", "name": "C1420466#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919442", "name": "C0919442#ent", "pos": [15, 16]}}
{"token": ["M-laminin", "is", "deficient", "in", "patients", "with", "the", "autosomal", "recessive", "Fukuyama", "C1416776#ent", "<e1>", "is", "normal", "in", "patients", "with", "the", "sex-linked", "Duchenne", "and", "C0917713#ent", "<e2>"], "h": {"id": "C1416776", "name": "C1416776#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0917713", "name": "C0917713#ent", "pos": [21, 22]}}
{"token": ["Anti-inflammatory", "cytokine", "TGF-beta(1", ")", "counteracted", "the", "effects", "of", "pro-inflammatory", "C1333196#ent", "<e1>", "IFN-gamma", "on", "membrane", "C1412409#ent", "<e2>", "expression", "in", "a", "time-", "and", "concentration-dependent", "fashion", ",", "suggesting", "a", "cytokine-regulated", "role", "of", "CD13/APN", "in", "inflammation", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412409", "name": "C1412409#ent", "pos": [14, 15]}}
{"token": ["C0079083#ent", "<e1>", "was", "well", "tolerated", "with", "no", "significant", "C1565662#ent", "<e2>", "ototoxicity", "detected", "."], "h": {"id": "C0079083", "name": "C0079083#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [8, 9]}}
{"token": ["C0166059#ent", "<e1>", "efficiently", "cleaved", "recombinant", "C1706006#ent", "<e2>", "in", "vitro", "reduced", "cell", "surface", "C1706006#ent", "<e2>", "expression", "."], "h": {"id": "C0166059", "name": "C0166059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [5, 6]}}
{"token": ["The", "IC50", "value", "of", "mefenamic", "acid", "human", "liver", "phenol", "sulfotransferase", "C4084746#ent", "<e1>", "was", "0.02", "microM", "and", "for", "human", "liver", "catechol", "sulfotransferase", "C0911506#ent", "<e2>", ")", "76", "microM", "with", "a", "SULT", "1A3/SULT1A1", "ratio", "for", "the", "IC50", "of", "3,800", "."], "h": {"id": "C4084746", "name": "C4084746#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0911506", "name": "C0911506#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "cotransfection", "of", "a", "C0669365#ent", "<e1>", "active", "mutant", "of", "Stat3", "along", "with", "a", "C0253457#ent", "<e2>", "promoter/luciferase", "reporter", "resulted", "in", "enhanced", "C0253457#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0253457", "name": "C0253457#ent", "pos": [15, 16]}}
{"token": ["A", "24", "h", "exposure", "to", "and", "10", "microM", "C0085176#ent", "<e1>", "produced", "42", "%", "and", "50", "%", "lethality", "in", "C4283853#ent", "<e2>", "but", "did", "not", "affect", "H630", "cells", "."], "h": {"id": "C0085176", "name": "C0085176#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "X-linked", "gene", "C1414635#ent", "<e1>", "FLNA", ")", "lead", "to", "the", "human", "C0027765#ent", "<e2>", "periventricular", "heterotopia", "PH", ")", "."], "h": {"id": "C1414635", "name": "C1414635#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [13, 14]}}
{"token": ["We", "measured", "the", "mRNA", "levels", "of", "C1384510#ent", "<e1>", ",", "transferrin", "receptor", "and", "two", "C1539748#ent", "<e2>", "cyclin", "B", "cdc25", ",", "in", "early", "mouse", "embryos", "by", "the", "RT-PCR", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539748", "name": "C1539748#ent", "pos": [13, 14]}}
{"token": ["Induction", "of", "C0011847#ent", "<e1>", "with", "streptozocin", "decreased", "the", "C1420175#ent", "<e2>", "to", "GLUT1", "ratio", "in", "adipose", "tissue", "and", "24", "h", "of", "insulin", "treatment", "the", "diabetic", "rats", "increased", "this", "ratio", "9-", "to", "10-fold", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [8, 9]}}
{"token": ["Three", "cysteine", "proteinase", "inhibitor", "cDNA", "clones", "pL1", ",", "C1540007#ent", "<e1>", ",", "and", "pN2", ")", "have", "been", "isolated", "from", "a", "C0947608#ent", "<e2>", "(", "Glycine", "max", "L.", "Merr", ")"], "h": {"id": "C1540007", "name": "C1540007#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0947608", "name": "C0947608#ent", "pos": [19, 20]}}
{"token": ["In", "myotonic", "dystrophy", "1", "DM1", ")", ",", "aggregation", "of", "the", "mutant", "DMPK", "RNA", "RNA-protein", "complexes", "containing", "MBNL1", "and", "C1424516#ent", "<e1>", "has", "been", "linked", "to", "aberrant", "splicing", "of", "the", "C1334133#ent", "<e2>", "IR", ")", "RNA", "."], "h": {"id": "C1424516", "name": "C1424516#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [28, 29]}}
{"token": ["The", "concentration-response", "curve", "C0170258#ent", "<e1>", "was", "shifted", "to", "the", "right", "by", "C0025654#ent", "<e2>", "in", "both", "preparations", "."], "h": {"id": "C0170258", "name": "C0170258#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025654", "name": "C0025654#ent", "pos": [11, 12]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "if", "chemotherapy", "induces", "nuclear", "factor-kappa", "B", "NF-kappaB", ")", "activation", "in", "NSCLC", "in", "vitro", "whether", "inhibition", "of", "C2986464#ent", "<e1>", "would", "sensitize", "tumor", "cells", "undergo", "C0549410#ent", "<e2>"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0549410", "name": "C0549410#ent", "pos": [31, 32]}}
{"token": ["The", "intracellular", "effectors", "known", "as", "2", "-", "5A", "(", "ppp-(A2'p)nA", ")", "regulate", "the", "cleavage", "of", "single-stranded", "RNA", "activating", "a", "C1333398#ent", "<e1>", "2", "-", "5A-dependent", "RNase", "or", "C0071795#ent", "<e2>", "."], "h": {"id": "C1333398", "name": "C1333398#ent", "pos": [19, 20]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0071795", "name": "C0071795#ent", "pos": [26, 27]}}
{"token": ["PHOX2B", "is", "a", "homeodomain-containing", "protein", "is", "involved", "in", "the", "development", "of", "the", "peripheral", "nervous", "system", "is", "the", "major", "C0019247#ent", "<e1>", "the", "rare", "congenital", "breathing", "disorder", "congenital", "central", "hypoventilation", "syndrome", "C1537630#ent", "<e2>", ")", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1537630", "name": "C1537630#ent", "pos": [29, 30]}}
{"token": ["However", ",", "the", "drugs", "were", "not", "equivalent", ":", "In", "addition", "to", "its", "greater", "potency", ",", "C0027302#ent", "<e1>", "differed", "from", "propranolol", "and", "C0025859#ent", "<e2>", "in", "the", "slope", "of", "its", "dose-response", "curve"], "h": {"id": "C0027302", "name": "C0027302#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [21, 22]}}
{"token": ["We", "report", "two", "female", "patients", "with", "C0030360#ent", "<e1>", "whom", "treatment", "with", "oral", "C0022265#ent", "<e2>", "produced", "remarkable", "improvement", "of", "the", "keratoderma", "within", "2", "weeks", "."], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [12, 13]}}
{"token": ["The", "C0017337#ent", "<e1>", "controlling", "synthesis", "of", "C0302359#ent", "<e2>", "and", "type-specific", "antigens", "were", "transferred", "to", "Escherichia", "coli", "recipients", "by", "conjugation", "with", "an", "S.", "flexneri", "Hfr", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0302359", "name": "C0302359#ent", "pos": [6, 7]}}
{"token": ["The", "COOH", "terminus", "of", "C1334868#ent", "<e1>", "interacted", "with", "C1421293#ent", "<e2>", "in", "vitro", "deletion", "of", "this", "region", "in", "C1334868#ent", "<e1>", "rendered", "it", "resistant", "to", "degradation", "in", "cells", "."], "h": {"id": "C1421293", "name": "C1421293#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334868", "name": "C1334868#ent", "pos": [4, 5]}}
{"token": ["Propiverine", ",", "its", "metabolites", "M-5", ",", "M-14", "and", "also", "C0388753#ent", "<e1>", "completely", "reduced", "detrusor", "contraction", "in", "C3714757#ent", "<e2>"], "h": {"id": "C0388753", "name": "C0388753#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [16, 17]}}
{"token": ["The", "taf72(+", ")", "and", "taf73(+", ")", "genes", "encode", "proteins", "C1334043#ent", "<e1>", "to", "WD", "repeat-containing", "TAFs", "such", "as", "human", "C1336560#ent", "<e2>", ",", "Drosophila", "TAF80/85", ",", "and", "Saccharomyces", "cerevisiae", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1336560", "name": "C1336560#ent", "pos": [18, 19]}}
{"token": ["In", "drug", "discrimination", "tests", "the", "mixed", ",", "D(1)/D(2", ")", "agonist", "apomorphine", ",", "the", "partial", "D(2", ")", "receptor", "agonists", "(-)-3-PPP", "and", "terguride", "and", "the", "5-HT(1A)", "agonist", "C0050079#ent", "<e1>", "substituted", "for", "C0023863#ent", "<e2>", "."], "h": {"id": "C0050079", "name": "C0050079#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0023863", "name": "C0023863#ent", "pos": [29, 30]}}
{"token": ["However", ",", "in", "the", "choroid-retina", "and", "optic", "nerve", "C0087093#ent", "<e1>", "concentrations", "were", "greater", "than", "those", "of", "C0733365#ent", "<e2>", "plus", "DHB", "."], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0733365", "name": "C0733365#ent", "pos": [16, 17]}}
{"token": ["Finally", ",", "reduction", "of", "C1418779#ent", "<e1>", "resulted", "in", "lower", "Thr172", "phosphorylation", "of", "C2350345#ent", "<e2>", "."], "h": {"id": "C1418779", "name": "C1418779#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2350345", "name": "C2350345#ent", "pos": [12, 13]}}
{"token": ["The", "NUP98-HOXA13", "fusion", "protein", "of", "the", "N-terminal", "phenylalanine-glycine", "repeat", "motif", "of", "C1334913#ent", "<e1>", "and", "the", "C-terminal", "homeodomain", "HOXA13", ",", "similar", "to", "the", "C1840524#ent", "<e2>", "fusion", "protein"], "h": {"id": "C1334913", "name": "C1334913#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1840524", "name": "C1840524#ent", "pos": [22, 23]}}
{"token": ["Load-induced", "activation", "of", "C1704657#ent", "<e1>", "was", "rapid", ",", "and", "the", "C0720099#ent", "<e2>", "of", "activation", "was", "dependent", "on", "the", "number", "of", "applied", "load", "cycles"], "h": {"id": "C1704657", "name": "C1704657#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [10, 11]}}
{"token": ["C0700606#ent", "<e1>", "may", "be", "an", "appropriate", "C0013227#ent", "<e2>", "for", "the", "rapid", "assessment", "and", "control", "of", "tachyarrhythmias", "in", "critically", "ill", "patients", "."], "h": {"id": "C0700606", "name": "C0700606#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [6, 7]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "C1418520#ent", "<e1>", "is", "a", "determinant", "of", "drug-inducible", "expression", "of", "C1176140#ent", "<e2>", "."], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [14, 15]}}
{"token": ["These", "exons", "encode", "conserved", "polypeptide", "domains", "within", "C0013765#ent", "<e1>", "and", "are", "found", "in", "the", "ELN", "C0079429#ent", "<e2>", "in", "vertebrate", "species", "from", "chickens", "to", "rats", "to", "cows", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [15, 16]}}
{"token": ["This", "report", "suggests", "that", "plasma", "exchange", "early", "in", "the", "course", "of", "recurrent", "C0027726#ent", "<e1>", "be", "beneficial", "in", "some", "patients", "with", "C3266102#ent", "<e2>", "FGS", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C3266102", "name": "C3266102#ent", "pos": [20, 21]}}
{"token": ["Data", "from", "experiments", "using", "reporter", "assays", "and", "overexpression", "of", "constitutively", "active", "IKK2", "support", "the", "hypothesis", "that", "the", "C1335875#ent", "<e1>", "and", "nuclear", "factor-kappaB", "(", "NF-kappaB", ")", "pathways", "collaborate", "in", "C1416867#ent", "<e2>", "genesis", "."], "h": {"id": "C1335875", "name": "C1335875#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [28, 29]}}
{"token": ["Those", "acutely", "affected", "had", "C0476273#ent", "<e1>", "signs", "of", "colic", "and", "many", "were", "C0003620#ent", "<e2>", "."], "h": {"id": "C0476273", "name": "C0476273#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [12, 13]}}
{"token": ["The", "genetic", "defect", "for", "C1707844#ent", "<e1>", "in", "three", "families", "was", "recently", "mapped", "to", "the", "long", "arm", "of", "chromosome", "II", "linkage", "between", "the", "C1707844#ent", "<e1>", "locus", "and", "the", "gene", "for", "C0917785#ent", "<e1>", "PYGM", ")", "at", "11q13", "."], "h": {"id": "C1707844", "name": "C1707844#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0917785", "name": "C0917785#ent", "pos": [29, 30]}}
{"token": ["Sf", "C1366479#ent", "<e1>", "activity", "is", "potently", "inhibited", "by", "C1334101#ent", "<e2>", ",", "suggesting", "that", "it", "is", "an", "important", "target", "of", "this", "antiapoptotic", "protein"], "h": {"id": "C1366479", "name": "C1366479#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334101", "name": "C1334101#ent", "pos": [8, 9]}}
{"token": ["Spontaneous", "correlated", "activity", "increased", "later", ",", "after", "animals", "became", "severely", "C1537501#ent", "<e1>", ",", "whereas", "synchronous", "oscillatory", "activity", "only", "after", "major", "C1457887#ent", "<e2>", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [20, 21]}}
{"token": ["C1418547#ent", "<e1>", "was", "localized", "in", "the", "cytoplasm", "in", "normal", "and", "C0012634#ent", "<e2>", "skin", "."], "h": {"id": "C1418547", "name": "C1418547#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["The", "C1865982#ent", "<e1>", "a", "rearranged", "form", "of", "the", "C0694890#ent", "<e2>", "has", "been", "found", "to", "be", "restricted", "to", "human", "papillary", "thyroid", "carcinomas"], "h": {"id": "C1865982", "name": "C1865982#ent", "pos": [1, 2]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [8, 9]}}
{"token": ["Interestingly", ",", "C1705556#ent", "<e1>", "also", "causes", "C1704910#ent", "<e2>", "to", "dissociate", "from", "TBP", ",", "which", "has", "not", "been", "previously", "observed", "with", "Mot1", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704910", "name": "C1704910#ent", "pos": [6, 7]}}
{"token": ["To", "determine", "whether", "there", "is", "a", "linkage", "between", "WT1", "expression", "and", "C1332386#ent", "<e1>", "breast", "cancer", "cells", "we", "studied", "the", "effect", "of", "WT1", "on", "C0039286#ent", "<e2>", "responsiveness", "in", "ERalpha-positive", "MCF-7", "cells"], "h": {"id": "C1332386", "name": "C1332386#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [23, 24]}}
{"token": ["Consistent", "with", "hepatotoxicity", "data", ",", "our", "results", "demonstrate", "that", "the", "gene", "expression", "affected", "by", "C1257987#ent", "<e1>", "and", "ciglitazone", "can", "be", "clearly", "distinguished", "from", "those", "by", "C0071097#ent", "<e2>", "and", "rosiglitazone", "."], "h": {"id": "C1257987", "name": "C1257987#ent", "pos": [14, 15]}, "relation": "chemical_structure_of", "t": {"id": "C0071097", "name": "C0071097#ent", "pos": [25, 26]}}
{"token": ["Although", "recombinant", "adenoviral", "vectors", "being", "widely", "used", "to", "target", "C1417679#ent", "<e1>", "to", "the", "nervous", "system", "the", "cellular", "and", "genetic", "effects", "recombinant", "C0851887#ent", "<e2>", "neuronal", "function", "not", "been", "well", "characterized", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0851887", "name": "C0851887#ent", "pos": [21, 22]}}
{"token": ["The", "C3536742#ent", "<e1>", "content", "in", "adrenergic", "plexuses", "the", "oxidative", "enzyme", "activity", "C0038615#ent", "<e2>", "lactate", "dehydrogenase", "during", "cold", "and", "emotional", "stress", "studied", "histochemically", "in", "the", "rat", "myocardium", "."], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0038615", "name": "C0038615#ent", "pos": [11, 12]}}
{"token": ["We", "have", "localized", "the", "human", "C1705127#ent", "<e1>", "chromosome", "13", "band", "q12", ",", "and", "its", "C1412544#ent", "<e2>", "chromosome", "5", "region", "G."], "h": {"id": "C1705127", "name": "C1705127#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412544", "name": "C1412544#ent", "pos": [14, 15]}}
{"token": ["Transcript", "profiling", "was", "used", "to", "look", "for", "C1417679#ent", "<e1>", "that", "differ", "in", "expression", "between", "the", "C0050795#ent", "<e2>", "deficient", "and", "hypomethylated", "hog1", "-", "1", "mutant", "and", "the", "parental", "(", "HOG1", ")", "line", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0050795", "name": "C0050795#ent", "pos": [15, 16]}}
{"token": ["C0086132#ent", "<e1>", "associated", "with", "increased", "physician", "visits", ",", "emergency", "room", "visits", "and", "hospitalizations", "for", "C0024115#ent", "<e2>"], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "identify", "C1414991#ent", "<e1>", ",", "the", "product", "of", "a", "growth", "arrest", "C0079429#ent", "<e2>", ",", "as", "a", "ligand", "for", "Mer", "."], "h": {"id": "C1414991", "name": "C1414991#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}}
{"token": ["These", "results", "indicate", "that", "high", "concentrations", "of", "unoprostone", "and", "beta-adrenergic", "blocking", "agents", "C0005320#ent", "<e1>", ",", "timolol", ",", "levobunolol", ",", "and", "C0007299#ent", "<e2>", "may", "inhibit", "ET-1-induced", "increase", "of", "[Ca2+]i", "."], "h": {"id": "C0005320", "name": "C0005320#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007299", "name": "C0007299#ent", "pos": [20, 21]}}
{"token": ["Vasodilator-stimulated", "phosphoprotein", "VASP", ")", "was", "identified", "as", "a", "substrate", "for", "C3494382#ent", "<e1>", "PKG", ")", "and", "C0010531#ent", "<e2>", "PKA", ")", "."], "h": {"id": "C3494382", "name": "C3494382#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [15, 16]}}
{"token": ["Finally", ",", "C0021236#ent", "<e1>", ",", "a", "recently", "discovered", "tryptophan", "metabolite", "strong", "C0036557#ent", "<e2>", "and", "hypotensive", "properties", ",", "has", "been", "shown", "to", "accumulate", "in", "cirrhotic", "patients", "and", "animal", "models", "HE", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036557", "name": "C0036557#ent", "pos": [11, 12]}}
{"token": ["This", "led", "us", "to", "conclude", "that", "C1705582#ent", "<e1>", "is", "a", "breakdown", "product", "of", "C1417754#ent", "<e2>", "."], "h": {"id": "C1705582", "name": "C1705582#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417754", "name": "C1417754#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", "lipoprotein", "thrombi", "associated", "with", "C2673196#ent", "<e1>", "not", "induced", "via", "C0020473#ent", "<e2>", "may", "be", "formed", "by", "intraglomerular", "accumulation", "of", "lipoprotein", "composed", "of", "abnormal", "apo", "E."], "h": {"id": "C2673196", "name": "C2673196#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [13, 14]}}
{"token": ["C1413297#ent", "<e1>", "activity", "was", "not", "regulated", "in", "a", "S.", "cerevisiae", "mutant", "strain", "C3537219#ent", "<e2>", ";", "an", "inositol", "biosynthesis", "regulatory", "mutant", "by", "the", "addition", "of", "phospholipid", "precursors", "the", "growth", "medium"], "h": {"id": "C1413297", "name": "C1413297#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537219", "name": "C3537219#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "genetic", "variation", "or", "C0132555#ent", "<e1>", "be", "involved", "in", "the", "pathogenesis", "of", "coronary", "artery", "disease", "C1504769#ent", "<e2>", ")", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [16, 17]}}
{"token": ["Prevention", "of", "abnormal", "mineral", "ion", "homeostasis", "by", "early", "institution", "of", "dietary", "therapy", "C1706113#ent", "<e1>", "null", "mice", "C0035579#ent", "<e2>", ",", "demonstrating", "that", "the", "C1706113#ent", "<e1>", "is", "not", "required", "for", "normal", "growth", "plate", "maturation", "."], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [16, 17]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706113", "name": "C1706113#ent", "pos": [12, 13]}}
{"token": ["C1426113#ent", "<e1>", "p21", "is", "a", "small", "C1427594#ent", "<e2>", "has", "the", "same", "amino", "acid", "sequence", "the", "effector", "loop", "of", "ras", "p21", "."], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427594", "name": "C1427594#ent", "pos": [6, 7]}}
{"token": ["We", "first", "show", "that", "activation", "of", "ERK1/2", "by", "the", "M(1", ")", "mAChR", "agonist", "carbachol", "takes", "place", "primarily", "via", "a", "Ras-independent", "pathway", "depends", "largely", "upon", "C1426113#ent", "<e1>", ",", "another", "small", "C1427594#ent", "<e2>", "the", "Ras", "family"], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1427594", "name": "C1427594#ent", "pos": [29, 30]}}
{"token": ["C1426113#ent", "<e1>", "is", "a", "small", "C1427594#ent", "<e2>", "has", "been", "implicated", "in", "intracellular", "signaling", "and", "cytoskeletal", "control"], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427594", "name": "C1427594#ent", "pos": [5, 6]}}
{"token": ["We", "recently", "reported", "that", "the", "inner", "nuclear", "membrane", "protein", "C1426208#ent", "<e1>", "is", "required", "to", "prevent", "unprocessed", "forms", "of", "Stp1", "and", "C1420515#ent", "<e2>", ",", "which", "ectopically", "enter", "the", "nucleus", ",", "from", "binding", "SPS", "sensor-regulated", "promoters", "."], "h": {"id": "C1426208", "name": "C1426208#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420515", "name": "C1420515#ent", "pos": [20, 21]}}
{"token": ["Fresh", "lymphocytes", "from", "schizophrenic", "patients", "showed", "no", "difference", "C0244989#ent", "<e1>", "GSK-3beta", "mRNA", "levels", ",", "C4283740#ent", "<e2>", ",", "or", "total", "GSK-3", "(", "alpha+beta", ")", "enzyme", "activity", "compared", "with", "findings", "in", "control", "subjects"], "h": {"id": "C0244989", "name": "C0244989#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [14, 15]}}
{"token": ["Modifications", "of", "gene", "expression", "occur", "in", "hepatitis", "B", "virus", "C0341439#ent", "<e1>", "possibly", "also", "involving", "ribosomal", "RNA", "rRNA", ")", "C1417679#ent", "<e2>", "contained", "in", "the", "nucleolus", "."], "h": {"id": "C0341439", "name": "C0341439#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["These", "anti-tyrosinase", "autoantibodies", "relatively", "high", "functional", "affinity", "to", "C0012524#ent", "<e1>", "and", "can", "be", "recovered", "from", "C0042900#ent", "<e2>", "patients", "'", "sera", "by", "affinity", "purification"], "h": {"id": "C0012524", "name": "C0012524#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [15, 16]}}
{"token": ["Antibodies", "to", "C0012524#ent", "<e1>", "have", "been", "reported", "in", "some", "patients", "with", "C0042900#ent", "<e2>", ",", "suggesting", "that", "vitiligo", "antibodies", "may", "be", "directed", "to", "this", "enzyme", "."], "h": {"id": "C0012524", "name": "C0012524#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [11, 12]}}
{"token": ["This", "study", "investigated", "the", "therapeutic", "efficacy", "of", "two", "different", "beta-blockers", ",", "C0025859#ent", "<e1>", "(", "beta", "1-selective", ")", "and", "C0132531#ent", "<e2>", "(", "nonselective", ")", "for", "the", "treatment", "of", "idiopathic", "dilated", "cardiomyopathy", "DCM", ")", "."], "h": {"id": "C0025859", "name": "C0025859#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0132531", "name": "C0132531#ent", "pos": [18, 19]}}
{"token": ["To", "test", "whether", "ascorbic", "acid", "be", "involved", "in", "the", "C0003402#ent", "<e1>", "inflammatory", "cells", "we", "studied", "ascorbate", "uptake", "recycling", "by", "quiescent", "and", "C3273508#ent", "<e2>", "RAW264.7", "murine", "macrophages", "."], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273508", "name": "C3273508#ent", "pos": [21, 22]}}
{"token": ["C0055775#ent", "<e1>", "decreased", "the", "following", "cellular", "antioxidants", "antioxidant", "enzymes", "vitamin", "C", "vitamin", "D", "DT-diaphorase", ",", "C0763282#ent", "<e2>", "glutathione-S-transferase", ",", "and", "glutathione", "reductase", "superoxide", "dismutase", "glutathione", "were", "not", "affected", "."], "h": {"id": "C0055775", "name": "C0055775#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0763282", "name": "C0763282#ent", "pos": [15, 16]}}
{"token": ["These", "are", "more", "powerful", "than", "previous", "technologies", "and", "can", "detect", "potentially", "C1512488#ent", "<e1>", "relationships", "missed", "by", "structural", "classifications", "as", "CATH", "and", "C3538841#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538841", "name": "C3538841#ent", "pos": [21, 22]}}
{"token": ["C0038085#ent", "<e1>", "SFK", ")", ",", "particularly", "p56(lck)", "Lck", ")", "and", "C1119966#ent", "<e2>", "Fyn", ")", ",", "are", "intimately", "associated", "with", "earliest", "signaling", "events", "the", "TCR", "and", "could", "provide", "targets", "for", "immunomodulatory", "agents"], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1119966", "name": "C1119966#ent", "pos": [10, 11]}}
{"token": ["To", "examine", "the", "effect", "of", "temperature", "on", "the", "antimicrobial", "efficacy", "of", "C0376261#ent", "<e1>", "and", "propionate", "against", "O157", "and", "non-O157", "Escherichia", "coli", "C1875400#ent", "<e2>", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "it", "is", "emphasized", "that", "seriously", "III", "patients", "and", "those", "who", "are", "prore", "to", "C0020615#ent", "<e1>", "should", "be", "carefully", "monitored", "when", "giving", "C0055461#ent", "<e2>"], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [23, 24]}}
{"token": ["Also", "identified", "were", "two", "C0812377#ent", "<e1>", "polymorphisms", "of", "four", "and", "three", "C0002085#ent", "<e2>", ",", "respectively", ",", "and", "a", "two-allele", "MspI", "polymorphism", "."], "h": {"id": "C0812377", "name": "C0812377#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [11, 12]}}
{"token": ["C0268487#ent", "<e1>", "in", "TLR-2", "or", "the", "shared", "TLR", "adapter", "molecule", "C1417530#ent", "<e2>", "have", "been", "shown", "to", "result", "in", "greatly", "increased", "bacterial", "burdens", "in", "mice", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417530", "name": "C1417530#ent", "pos": [10, 11]}}
{"token": ["Twenty-five", "patients", "with", "35", "bedsores", "were", "treated", "with", "dextranomer", "(", "C0057621#ent", "<e1>", ";", "Adcock", "Ingram", ")", "applied", "topically", "to", "the", "C0149745#ent", "<e2>", "."], "h": {"id": "C0057621", "name": "C0057621#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0149745", "name": "C0149745#ent", "pos": [20, 21]}}
{"token": ["We", "show", "that", "these", "motifs", "are", "efficiently", "phosphorylated", "by", "C0108555#ent", "<e1>", "CK2", ")", "in", "vitro", "directly", "interact", "with", "the", "N-terminal", "forkhead-associated", "domain", "C3811665#ent", "<e2>", "in", "a", "phosphorylation-dependent", "manner", "."], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811665", "name": "C3811665#ent", "pos": [22, 23]}}
{"token": ["MK-771", "evoked", "two", "types", "of", "shaking", "behavior", "head", "shakes", "C1367673#ent", "<e1>", ")", "and", "wet-dog", "shakes", "(", "C1706584#ent", "<e2>", ")", "."], "h": {"id": "C1367673", "name": "C1367673#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706584", "name": "C1706584#ent", "pos": [16, 17]}}
{"token": ["The", "Km", "of", "thioredoxin", "B", "this", "C0016755#ent", "<e1>", "was", "determined", "to", "be", "1.7", "\u03bcM", ",", "endicotiy", "that", "C3496084#ent", "<e2>", "might", "activate", "the", "C0016755#ent", "<e1>", "in", "Synechococcus", "in", "vivo"], "h": {"id": "C0016755", "name": "C0016755#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3496084", "name": "C3496084#ent", "pos": [17, 18]}}
{"token": ["In", "addition", "to", "C1706517#ent", "<e1>", ",", "L929CM", "contains", "high", "amounts", "VEGF", ",", "C1705079#ent", "<e2>", ",", "KC", ",", "and", "MIG", ",", "and", "low", "amounts", "FGF-beta", ",", "Eotaxin", ",", "IL-10", ",", "IL-9", ",", "and", "IL-12", "."], "h": {"id": "C1706517", "name": "C1706517#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705079", "name": "C1705079#ent", "pos": [12, 13]}}
{"token": ["The", "140,000-dalton", "protein", "shows", "strong", "homology", "with", "the", "large", "subunit", "of", "well-characterized", "ribonucleotide", "reductase", "C3541394#ent", "<e1>", "from", "the", "mouse", "and", "from", "Escherichia", "coli", "with", "an", "C1414234#ent", "<e2>"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414234", "name": "C1414234#ent", "pos": [25, 26]}}
{"token": ["The", "ALS", "gene", "family", "Candida", "albicans", "of", "eight", "C1417679#ent", "<e1>", "(", "ALS1", "to", "ALS7", "and", "C2678468#ent", "<e2>", ")", "that", "encode", "cell-wall", "glycoproteins", "involved", "in", "adhesion", "to", "host", "surfaces", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2678468", "name": "C2678468#ent", "pos": [15, 16]}}
{"token": ["p21-activated", "kinase", "5", "C1423829#ent", "<e1>", ")", "is", "an", "effector", "for", "the", "small", "C0018296#ent", "<e2>", "Cdc42", ",", "known", "to", "activate", "cell", "survival", "signaling", "pathways"], "h": {"id": "C1423829", "name": "C1423829#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [12, 13]}}
{"token": ["C4277608#ent", "<e1>", "were", "also", "isolated", "from", "Arabidopsis", "thaliana", "gene", "silencing", "1", "(", "C1427656#ent", "<e2>", ")", "and", "Orzya", "sativa", "(", "OsCBP", ")", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427656", "name": "C1427656#ent", "pos": [12, 13]}}
{"token": ["We", "report", "the", "analysis", "of", "a", "36-kbp", "region", "of", "the", "Neurospora", "crassa", "genome", ",", "which", "contains", "C4277608#ent", "<e1>", "of", "two", "closely", "linked", "stationary", "phase", "genes", "SNZ1", "and", "C1427656#ent", "<e2>", ",", "from", "Saccharomyces", "cerevisiae"], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1427656", "name": "C1427656#ent", "pos": [27, 28]}}
{"token": ["Our", "results", "strongly", "suggest", "that", "C3539645#ent", "<e1>", "activation", "blocks", "thymocyte", "apoptosis", "by", "preventing", "Ca2", "+", "-stimulated", "C0014230#ent", "<e2>", "activation", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014230", "name": "C0014230#ent", "pos": [16, 17]}}
{"token": ["Human", "neutrophils", "lacked", "or", "expressed", "low", "levels", "of", "most", "Slp/Slac2", "proteins", ",", "putative", "C1419195#ent", "<e1>", "effectors", ",", "suggesting", "that", "additional", "proteins", "should", "act", "as", "C1624014#ent", "<e2>", "effectors", "in", "human", "neutrophils", "."], "h": {"id": "C1419195", "name": "C1419195#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1624014", "name": "C1624014#ent", "pos": [24, 25]}}
{"token": ["We", "describe", "the", "first", "patient", ",", "to", "our", "knowledge", ",", "to", "receive", "a", "diagnosis", "of", "C0151332#ent", "<e1>", "concurrent", ",", "severe", "C0027765#ent", "<e2>", "including", "peripheral", "neuropathy"], "h": {"id": "C0151332", "name": "C0151332#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [20, 21]}}
{"token": ["Alterations", "of", "catalytic", "activities", "the", "C0017755#ent", "<e1>", "examined", "following", "either", "ferrous", "iron-", "or", "C0018549#ent", "<e2>", "(", "CF3CHBrCl", ")", "and", "carbon", "tetrachloride", "CCl4", ")", "free-radical-mediated", "peroxidation", "of", "the", "microsomal", "membrane"], "h": {"id": "C0017755", "name": "C0017755#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [13, 14]}}
{"token": ["In", "this", "regard", ",", "levels", "of", "both", "PGE2", "and", "C0058310#ent", "<e1>", "increased", "in", "response", "to", "C1524095#ent", "<e2>", "."], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1524095", "name": "C1524095#ent", "pos": [15, 16]}}
{"token": ["Long-Evans", "Cinnamon", "LEC", ")", "rats", "are", "autosomal", "C0017361#ent", "<e1>", "mutants", "that", "develop", "C0019158#ent", "<e2>", "and", "hepatocellular", "carcinoma"], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [12, 13]}}
{"token": ["Angiotensin", "II", "a", "potent", "mediator", "of", "myocardial", "growth", "and", "angiotensin", "II", "be", "produced", "in", "the", "heart", "by", "C1413931#ent", "<e1>", "ACE", ")", "and", "C4085186#ent", "<e2>", "CMA", ")", "."], "h": {"id": "C1413931", "name": "C1413931#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4085186", "name": "C4085186#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "a", "catalytic", "inactive", "of", "C1704708#ent", "<e1>", "or", "C1704708#ent", "<e1>", "small", "interfering", "RNA", "blunted", "TNF-induced", "dephosphorylation", "of", "C1417014#ent", "<e1>", "pSer967", "and", "activation", "of", "JNK", "without", "effects", "on", "NF-kappaB", "activation"], "h": {"id": "C1704708", "name": "C1704708#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417014", "name": "C1417014#ent", "pos": [19, 20]}}
{"token": ["Overexpression", "of", "C1704708#ent", "<e1>", "catalytic", "subunit", "induced", "dephosphorylation", "of", "C1417014#ent", "<e2>", "pSer967", "and", "activation", "of", "c-Jun", "N-terminal", "kinase", "JNK", ")", "."], "h": {"id": "C1704708", "name": "C1704708#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417014", "name": "C1417014#ent", "pos": [9, 10]}}
{"token": ["C3541244#ent", "<e1>", ",", "-2", ",", "and", "-8", "code", "for", "C0030956#ent", "<e2>", "YRPRPRRY", "."], "h": {"id": "C3541244", "name": "C3541244#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}}
{"token": ["Numerous", "other", "C0003015#ent", "<e1>", "in", "clinical", "evaluation", "including", "C0950721#ent", "<e2>", "and", "PD184352", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0950721", "name": "C0950721#ent", "pos": [8, 9]}}
{"token": ["Central", "administration", "C3813124#ent", "<e1>", "caused", "a", "significant", "increase", "in", "the", "plasma", "C1418208#ent", "<e2>", "level", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418208", "name": "C1418208#ent", "pos": [11, 12]}}
{"token": ["C1825432#ent", "<e1>", "(", "LepA", ")", "is", "an", "almost", "universally", "conserved", "translational", "C0018296#ent", "<e2>", "in", "eubacteria", "."], "h": {"id": "C1825432", "name": "C1825432#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [11, 12]}}
{"token": ["We", "show", "that", "the", "C0221018#ent", "<e1>", "phenotype", "in", "C1853733#ent", "<e2>", "associated", "with", "nonconservative", "missense", "mutation", "the", "ferroportin", "gene"], "h": {"id": "C0221018", "name": "C0221018#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1853733", "name": "C1853733#ent", "pos": [8, 9]}}
{"token": ["1160", "-", "1250", "pg/ml", "vs.", "200", "-", "395", "pg/ml", ")", "compared", "with", "those", "in", "C2129214#ent", "<e1>", "patients", "with", "C0013369#ent", "<e2>"], "h": {"id": "C2129214", "name": "C2129214#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013369", "name": "C0013369#ent", "pos": [18, 19]}}
{"token": ["Real-time", "quantitative", "PCR", "used", "to", "measure", "expression", "levels", "of", "C1417679#ent", "<e1>", "encoding", "efflux", "pumps", "ERG11", "and", "two", "control", "genes", "C1332801#ent", "<e2>", "and", "PMA1", ",", "in", "a", "collection", "of", "14", "fluconazole-susceptible", "Candida", "albicans", "isolates", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332801", "name": "C1332801#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "we", "did", "not", "detect", "the", "C1413049#ent", "<e1>", "mutation", "on", "146", "sporadic", "cases", "with", "isolated", "cerebellar", "ataxia", "C0028968#ent", "<e2>"], "h": {"id": "C1413049", "name": "C1413049#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028968", "name": "C0028968#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "57-year-old", "woman", "with", "genetically", "confirmed", "C1413049#ent", "<e1>", "who", "showed", "clinical", "features", "of", "C0028968#ent", "<e2>"], "h": {"id": "C1413049", "name": "C1413049#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028968", "name": "C0028968#ent", "pos": [15, 16]}}
{"token": ["The", "unique", "C-terminal", "third", "of", "p65", "contained", "at", "least", "one", "more", "activation", "domain", "C1412137#ent", "<e1>", ",", "within", "a", "90", "amino", "acid", "sequence", "adjacent", "to", "C1539908#ent", "<e2>", "."], "h": {"id": "C1412137", "name": "C1412137#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1539908", "name": "C1539908#ent", "pos": [24, 25]}}
{"token": ["Genomic", "sequences", "the", "C1417123#ent", "<e1>", "and", "the", "human", "beta-globin", "(", "C1825776#ent", "<e2>", ")", "reference", "gene", "two", "competitors", "for", "the", "C1417123#ent", "<e1>", "and", "reference", "gene", "amplified", "with", "two", "primer", "pairs", "simultaneously", "."], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1825776", "name": "C1825776#ent", "pos": [10, 11]}}
{"token": ["Several", "markers", "of", "muscle", "mitochondrial", "fatty", "acid", "capacity", "were", "measured", ",", "including", "(14)C-palmitate", "oxidation", ",", "palmitoyl-CoA", "oxidation", "isolated", "mitochondria", ",", "oxidative", "enzyme", "activity", "citrate", "synthase", "beta-hydroxyacyl", "CoA", "dehydrogenase", "C1412107#ent", "<e1>", "and", "carnitine", "palmitoyl-transferase", "1", ",", "and", "expression", "of", "C0086376#ent", "<e2>", "involved", "in", "mitochondrial", "metabolism"], "h": {"id": "C1412107", "name": "C1412107#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [38, 39]}}
{"token": ["Granzyme", "B", "the", "prototypic", "member", "of", "the", "C1333877#ent", "<e1>", ",", "a", "family", "of", "C1447694#ent", "<e2>", "localized", "in", "the", "dense", "cytoplasmic", "granules", "activated", "natural", "killer", "cells", "cytotoxic", "T", "lymphocytes"], "h": {"id": "C1333877", "name": "C1333877#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1447694", "name": "C1447694#ent", "pos": [13, 14]}}
{"token": ["Urinary", "excretion", "C1418587#ent", "<e1>", "usually", "paralleled", "the", "increases", "in", "plasma", "levels", "the", "C0072522#ent", "<e2>", "during", "the", "first", "six", "days", "of", "therapy", "."], "h": {"id": "C1418587", "name": "C1418587#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}}
{"token": ["C1418587#ent", "<e1>", "GCDFP-15", ")", "is", "a", "60,000", "dalton", "C0072522#ent", "<e2>", "isolated", "from", "human", "breast", "cyst", "fluid", "composed", "of", "four", "15,000", "dalton", "monomers"], "h": {"id": "C1418587", "name": "C1418587#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [8, 9]}}
{"token": ["The", "diagnosis", "of", "C0025309#ent", "<e1>", "due", "to", "primary", "EBV", "infection", "supported", "by", "a", "C0272210#ent", "<e2>", "an", "increased", "antibody", "level", "and", "positive", "EBV", "PCR", "in", "the", "CSF", "."], "h": {"id": "C0025309", "name": "C0025309#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0272210", "name": "C0272210#ent", "pos": [13, 14]}}
{"token": ["All", "cases", "were", "positive", "for", "C1537501#ent", "<e1>", ",", "CK", "19", "and", "pancytokeratin", "but", "were", "negative", "for", "C3811254#ent", "<e2>", "and", "CA", "125", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3811254", "name": "C3811254#ent", "pos": [16, 17]}}
{"token": ["Prompted", "by", "studies", "reporting", "re-expression", "of", "the", "C1414304#ent", "<e1>", "in", "germinal", "center", "B", "cells", "the", "expression", "of", "C1414304#ent", "<e1>", "and", "terminal", "deoxynucleotidyl", "transferase", "C3887634#ent", "<e1>", ")", "in", "human", "lymphoid", "tissues", "examined", "using", "in", "situ", "hybridization", "immunohistochemistry", ",", "respectively", "."], "h": {"id": "C1414304", "name": "C1414304#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3887634", "name": "C3887634#ent", "pos": [23, 24]}}
{"token": ["We", "find", "that", "both", "the", "thioredoxin", "and", "C0061505#ent", "<e1>", "to", "reducing", "disulfide", "bonds", "C1333199#ent", "<e2>"], "h": {"id": "C0061505", "name": "C0061505#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333199", "name": "C1333199#ent", "pos": [13, 14]}}
{"token": ["These", "clinical", "and", "neuroradiological", "features", "are", "those", "of", "C2751843#ent", "<e1>", "subcortical", "cysts", "MLC", ")", ",", "a", "recently", "delineated", "C0270612#ent", "<e2>", "onset", "in", "childhood", "."], "h": {"id": "C2751843", "name": "C2751843#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0270612", "name": "C0270612#ent", "pos": [18, 19]}}
{"token": ["They", "include", ":", "facet", "joint", "pathology", "(", "e.g.", ",", "C0949690#ent", "<e1>", ",", "joint", "effusion", "synovitis", "and", "C0085648#ent", "<e2>", ",", "spondylolysis", ",", "spinal/perispinal", "ligamentous", "degenerative-inflammatory", "changes", "and", "perispinal", "muscular", "changes", "."], "h": {"id": "C0949690", "name": "C0949690#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [16, 17]}}
{"token": ["Bone", "marrow", "cells", "by", "expression", "of", "the", "C0291573#ent", "<e1>", "and", "c-kit", "Ags", "lacking", "C0796126#ent", "<e2>", "of", "differentiating", "lineages", "were", "segregated", "into", "subsets", "based", "on", "allele-specific", "Thy-1.1", "Ag", "expression", "."], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "the", "C-A", "haplotype", "the", "C-A-G", "haplotype", "of", "the", "GUCA2B", "gene", "the", "genetic", "markers", "EH", ",", "and", "that", "C4283931#ent", "<e1>", "or", "a", "neighboring", "C0017337#ent", "<e2>", "might", "be", "a", "susceptibility", "gene", "EH", "."], "h": {"id": "C4283931", "name": "C4283931#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [26, 27]}}
{"token": ["Surprisingly", ",", "cells", "transformed", "with", "the", "C0079473#ent", "<e1>", "elevated", "basal", "levels", "both", "C0377309#ent", "<e2>", "and", "MT-II", "RNA", "."], "h": {"id": "C0079473", "name": "C0079473#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0377309", "name": "C0377309#ent", "pos": [12, 13]}}
{"token": ["AAA", "was", "compared", "between", "those", "with", "and", "without", "isolated", "systolic", "hypertension", "C0020498#ent", "<e1>", ")", "and", "prevalence", "of", "C0004153#ent", "<e2>", "evaluated", "."], "h": {"id": "C0020498", "name": "C0020498#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [17, 18]}}
{"token": ["These", "disorders", "share", "the", "C0159028#ent", "<e1>", "hypomagnesemia", ",", "tetany", "and", "C0036572#ent", "<e2>", "and", "often", "include", "secondary", "or", "associated", "disturbances", "in", "calcium", "excretion"], "h": {"id": "C0159028", "name": "C0159028#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}}
{"token": ["As", "C1335227#ent", "<e1>", "shown", "to", "colocalize", "and", "coimmunoprecipitate", "with", "C1424448#ent", "<e2>", "[", "Tsvetkov", "et", "al.", ",", "J.", "Biol", "."], "h": {"id": "C1335227", "name": "C1335227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1424448", "name": "C1424448#ent", "pos": [9, 10]}}
{"token": ["Low", "levels", "of", "alpha-tocopherol", "(", "C4049625#ent", "<e1>", ")", "are", "associated", "with", "increased", "incidence", "of", "C0003850#ent", "<e2>", "and", "increased", "intakes", "appear", "to", "be", "protective", "."], "h": {"id": "C4049625", "name": "C4049625#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [14, 15]}}
{"token": ["Statistical", "comparisons", "were", "performed", "between", "PCT", "patients", "and", "healthy", "controls", "liver", "disease", "patients", "(", "cirrhosis", ",", "chronic", "active", "hepatitis", "and", "patients", "with", "associated", "liver", "siderosis", "C0023891#ent", "<e1>", "cirrhosis", "and", "chronic", "active", "hepatitis", "C0005283#ent", "<e2>", ")", "."], "h": {"id": "C0023891", "name": "C0023891#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [32, 33]}}
{"token": ["The", "correlation", "of", "C0019693#ent", "<e1>", "infectivity", "outcome", "with", "surface", "C3538705#ent", "<e2>", "and", "circulating", "alpha(1)PI", "supports", "the", "utility", "of", "these", "C0019693#ent", "<e1>", "cofactors", "in", "diagnostic", "analysis", "therapeutic", "intervention"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3538705", "name": "C3538705#ent", "pos": [9, 10]}}
{"token": ["In", "the", "present", "paper", ",", "we", "analyzed", "two", "antigens", "which", "classically", "define", "the", "macrophage", "family", "Mac-1", "and", "C3539738#ent", "<e1>", ",", "as", "well", "as", "major", "C0024518#ent", "<e2>", "is", "present", "on", "epithelial", "cells", "on", "bone", "marrow", "stromal", "cells"], "h": {"id": "C3539738", "name": "C3539738#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [24, 25]}}
{"token": ["This", "emerging", "evidence", "suggests", "that", "further", "studies", "are", "warranted", "to", "determine", "the", "importance", "of", "F(2)-isoprostanes", "in", "human", "C0022658#ent", "<e1>", "by", "renal", "vasoconstriction", "such", "as", "renal", "ischemia", "C0019212#ent", "<e2>", "renal", "senescence", "toxic", "nephropathies"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0019212", "name": "C0019212#ent", "pos": [26, 27]}}
{"token": ["Local", "injection", "of", "the", "5-HT3", "receptor", "antagonist", "tropisetron", "manifests", "a", "distinct", "analgesic", "effect", "various", "C0277565#ent", "<e1>", "the", "locomotor", "system", "as", "C4277745#ent", "<e2>", ",", "peri-arthropathies", ",", "myofascial", "pain", "syndrome", "in", "trigger", "points", "and", "in", "inflammatory", "joint", "processes"], "h": {"id": "C0277565", "name": "C0277565#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4277745", "name": "C4277745#ent", "pos": [20, 21]}}
{"token": ["C1800706#ent", "<e1>", "IPF", ")", ",", "or", "C0085786#ent", "<e2>", "it", "is", "known", "in", "the", "United", "Kingdom", "Europe", ",", "is", "perhaps", "one", "of", "the", "most", "complex", "and", "frustrating", "pulmonary", "disorders"], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085786", "name": "C0085786#ent", "pos": [6, 7]}}
{"token": ["Bronchoalveolar", "lavage", "cells", "obtained", "from", "40", "patients", "with", "C0085786#ent", "<e1>", "22", "with", "C1800706#ent", "<e2>", "and", "18", "with", "connective", "tissue", "disease", "(", "CTD", ")", "C0085786#ent", "<e1>"], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085786", "name": "C0085786#ent", "pos": [8, 9]}}
{"token": ["Idiopathic", "pulmonary", "fibrosis", "C1800706#ent", "<e1>", ")", ",", "also", "called", "interstitial", "pneumonia", "C0085786#ent", "<e2>", "is", "a", "progressive", "interstitial", "lung", "disease", "unknown", "origin", "."], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085786", "name": "C0085786#ent", "pos": [11, 12]}}
{"token": ["Our", "data", "indicate", "that", "the", "proinflammatory", "cytokines", "IL-1beta", "and", "C1710304#ent", "<e1>", "induce", "the", "overgrowth", "of", "synovial", "cells", "upregulating", "C1428377#ent", "<e2>", "expression", "via", "the", "Erk1/-ETS1", "pathway", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1428377", "name": "C1428377#ent", "pos": [18, 19]}}
{"token": ["The", "amino", "acid", "sequence", "a", "C0030956#ent", "<e1>", "derived", "from", "C3273618#ent", "<e2>", "phosphorylated", "with", "IP-K", ",", "RHARVT*VK", ",", "shared", "one", "of", "the", "consensus", "sequences", "by", "protein", "kinase", "C", "PKC", ")", ",", "where", "T", "*", "was", "phosphorylated", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273618", "name": "C3273618#ent", "pos": [9, 10]}}
{"token": ["The", "Km", "(", "C0360714#ent", "<e1>", ")", ",", "thermal", "stability", "and", "susceptibility", "to", "inhibition", "by", "Mg2+", "C1705556#ent", "<e2>", "of", "HMG-CoA", "reductase", "unaltered", "in", "both", "of", "the", "resistant", "lines", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [15, 16]}}
{"token": ["In", "an", "Italian", "patient", "with", "C0015530#ent", "<e1>", "a", "novel", "mutation", ",", "Y283C", "(", "TAT", "to", "C1428265#ent", "<e2>", ")", ",", "was", "identified", "heterozygously", "by", "nucleotide", "sequencing", "analysis", "exon", "VII", "the", "gene", "for", "the", "A", "subunit", "."], "h": {"id": "C0015530", "name": "C0015530#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1428265", "name": "C1428265#ent", "pos": [15, 16]}}
{"token": ["However", ",", "when", "stably", "expressed", "in", "HEK-293", "cells", ",", "C1427112#ent", "<e1>", "can", "be", "activated", "by", "either", "Ca(2+)", "depletion", "or", "C0031669#ent", "<e2>", "activation", "."], "h": {"id": "C1427112", "name": "C1427112#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [19, 20]}}
{"token": ["It", "is", "concluded", "that", ",", "in", "man", ",", "C0062619#ent", "<e1>", "can", "modify", "the", "action", "of", "C0038627#ent", "<e2>", "by", "two", "different", "mechanisms", "."], "h": {"id": "C0062619", "name": "C0062619#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038627", "name": "C0038627#ent", "pos": [15, 16]}}
{"token": ["The", "effect", "of", "C0062619#ent", "<e1>", "0.3", "mg/kg", "on", "the", "neuromuscular", "block", "C0038627#ent", "<e2>", "0.1", "mg/kg", "in", "a", "child", "with", "homozygote", "atypical", "plasma", "cholinesterase", "activity", "and", "in", "one", "of", "his", "normal", "brothers", "been", "compared", "."], "h": {"id": "C0062619", "name": "C0062619#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038627", "name": "C0038627#ent", "pos": [11, 12]}}
{"token": ["PKCalpha", "or", "C0524684#ent", "<e1>", "are", "not", "involved", "in", "stimulation", "by", "intracellular", "C0001477#ent", "<e2>"], "h": {"id": "C0524684", "name": "C0524684#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "using", "EPO-deficient", "mice", "and", "an", "EPO", "inhibitor", "C0073085#ent", "<e1>", "we", "demonstrate", "that", "C0059407#ent", "<e2>", "critical", "in", "the", "development", "of", "GI", "dysfunction", "experimental", "UC", "."], "h": {"id": "C0073085", "name": "C0073085#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0059407", "name": "C0059407#ent", "pos": [14, 15]}}
{"token": ["The", "mutant", "Fur", "proteins", "purified", "and", "examined", "for", "their", "ability", "to", "bind", "to", "the", "promoter", "of", "a", "gene", "(", "C0085096#ent", "<e1>", ")", "that", "positively", "regulates", "the", "expression", "of", "siderophores", "and", "C2348358#ent", "<e2>", "."], "h": {"id": "C0085096", "name": "C0085096#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2348358", "name": "C2348358#ent", "pos": [30, 31]}}
{"token": ["V98I", ")", "in", "the", "human", "C3539602#ent", "<e1>", "gene", "that", "encodes", "the", "mitochondrial", "C1415782#ent", "<e2>", "a", "dominantly", "inherited", "form", "of", "hereditary", "spastic", "paraplegia"], "h": {"id": "C3539602", "name": "C3539602#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415782", "name": "C1415782#ent", "pos": [12, 13]}}
{"token": ["We", "report", "the", "outcome", "of", "treatment", "with", "NIPPV", "of", "four", "C0002895#ent", "<e1>", "pregnant", "patients", "with", "C0525037#ent", "<e2>", "caused", "by", "acute", "chest", "syndrome"], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [15, 16]}}
{"token": ["The", "number", "of", "apoptotic", "cells", "C0012881#ent", "<e1>", ",", "the", "number", "of", "scavenger-receptor-positive", "macrophages", "and", "expression", "level", "of", "C1533698#ent", "<e2>", "iNOS", ")", "within", "lesions", "directly", "correlated", "with", "therapeutic", "effects"], "h": {"id": "C0012881", "name": "C0012881#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [17, 18]}}
{"token": ["To", "study", "the", "effect", "of", "C0003364#ent", "<e1>", "autonomic", "nervous", "system", "patients", "with", "hypertension", "and", "C0520680#ent", "<e2>", "frequency", "domain", "measures", "of", "heart", "rate", "blood", "pressure", "variabilities", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0520680", "name": "C0520680#ent", "pos": [14, 15]}}
{"token": ["Further", ",", "the", "expression", "of", "TPS1", ",", "encoding", "trehalose-6-phosphate", "synthase", "1", "and", "C1424667#ent", "<e1>", "was", "activated", "by", "Gts1p", "in", "combination", "with", "C0142751#ent", "<e2>", "a", "transcriptional", "activator", "glucose-repressible", "genes", ",", "in", "batch", "cultures", "derepressed", "conditions", "."], "h": {"id": "C1424667", "name": "C1424667#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0142751", "name": "C0142751#ent", "pos": [21, 22]}}
{"token": ["Conventional", "T2W-MRI", "in", "3", "out", "of", "10", "patients", "showed", "C0221021#ent", "<e1>", "subcortical", "changes", "and", "C0038454#ent", "<e2>", "older", "origin"], "h": {"id": "C0221021", "name": "C0221021#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [14, 15]}}
{"token": ["Sequence", "analysis", "the", "C1861917#ent", "<e1>", "cDNA", "showed", "that", "C1333214#ent", "<e2>", "and", "can", "are", "merged", "without", "disruption", "of", "the", "original", "open", "reading", "frames", "therefore", "the", "fusion", "mRNA", "encodes", "a", "chimeric", "DEK-CAN", "protein", "of", "165", "kDa", "."], "h": {"id": "C1861917", "name": "C1861917#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1333214", "name": "C1333214#ent", "pos": [8, 9]}}
{"token": ["Thus", ",", "we", "conclude", "that", "transcriptional", "regulation", "DOC-2/DAB2", "gene", "human", "C0076456#ent", "<e1>", "is", "determined", "by", "histone", "acetylation", "a", "specific", "transcription", "factor", "i.e.", ",", "C3542968#ent", "<e2>", ")", ",", "which", "underlie", "the", "reduced", "DOC-2/DAB2", "protein", "expression", "in", "TCC", "cells"], "h": {"id": "C0076456", "name": "C0076456#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3542968", "name": "C3542968#ent", "pos": [23, 24]}}
{"token": ["New", "spectrophotometric", "fluorimetric", "methods", "have", "been", "developed", "to", "determine", "diazepam", ",", "bromazepam", "and", "clonazepam", "(", "C4048284#ent", "<e1>", ")", "in", "pure", "forms", ",", "C1720946#ent", "<e2>", "biological", "fluid"], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1720946", "name": "C1720946#ent", "pos": [22, 23]}}
{"token": ["The", "inhibition", "of", "calcium", "influx", "or", "C0033681#ent", "<e1>", "mitogen-activated", "protein", "MAP", ")", "kinase", "prevents", "C1328053#ent", "<e2>", "stimulation", "by", "estrogen", ",", "and", "estrogen", "causes", "rapid", "ER-dependent", "activation", "of", "MAP", "kinase"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [14, 15]}}
{"token": ["The", "average", "interval", "between", "subsequent", "fasciculations", "can", "not", "be", "used", "to", "differentiate", "patients", "with", "acquired", "and", "C0598589#ent", "<e1>", "with", "lower", "C0085084#ent", "<e2>"], "h": {"id": "C0598589", "name": "C0598589#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [20, 21]}}
{"token": ["Eleven", "presented", "with", "other", "nerve", "entrapment", "syndromes", "or", "focal", "mononeuropathies", "due", "to", "C0598589#ent", "<e1>", "liability", "to", "pressure", "palsy", "or", "C0085084#ent", "<e2>"], "h": {"id": "C0598589", "name": "C0598589#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [19, 20]}}
{"token": ["If", "C0812382#ent", "<e1>", "to", "be", "studied", ",", "a", "C0597094#ent", "<e2>", "(", "e.g.", ",", "Benzonase", ")", "should", "be", "included", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0597094", "name": "C0597094#ent", "pos": [8, 9]}}
{"token": ["C0008809#ent", "<e1>", "was", "compared", "with", "ceftriaxone", "in", "a", "rabbit", "model", "of", "C0003869#ent", "<e2>", "by", "Escherichia", "coli"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0003869", "name": "C0003869#ent", "pos": [11, 12]}}
{"token": ["We", "report", "that", "Escherichia", "coli", "C0084304#ent", "<e1>", "can", "also", "unwind", "G4", "C0011522#ent", "<e2>", ",", "and", "that", "unwinding", "requires", "ATP", "and", "divalent", "cation"], "h": {"id": "C0084304", "name": "C0084304#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [11, 12]}}
{"token": ["Minimal", "inhibitory", "concentrations", "(", "MIC", ")", "of", "all", "strains", "tested", "to", "amphotericin", "B", "C0064113#ent", "<e1>", "increased", "in", "the", "presence", "of", "physiological", "concentrations", "of", "human", "C1412332#ent", "<e2>", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [24, 25]}}
{"token": ["Glutathione", "S-transferase", "fusion", "protein", "pull-down", "that", "the", "POZ", "domains", "of", "C1705361#ent", "<e1>", ",", "Plzf", ",", "and", "C4284136#ent", "<e2>", "directly", "interact", "with", "the", "zinc", "finger", "DNA", "binding", "domain", "Sp1", "."], "h": {"id": "C1705361", "name": "C1705361#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4284136", "name": "C4284136#ent", "pos": [16, 17]}}
{"token": ["Disabling", "propranolol-induced", "bronchospasm", "occasionally", "prevents", "use", "of", "this", "C0013227#ent", "<e1>", "in", "patients", "with", "chronic", "obstructive", "pulmonary", "disease", "C0024117#ent", "<e2>", ")", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "a", "correlation", "was", "found", "between", "tumor", "response", "chemotherapy", "and", "the", "expression", "level", "of", "the", "C0597298#ent", "<e1>", "but", "not", "of", "C0256024#ent", "<e2>", "topoisomerase", "I", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0256024", "name": "C0256024#ent", "pos": [21, 22]}}
{"token": ["To", "begin", "to", "address", "this", "issue", ",", "the", "infiltrating", "cells", "frozen", "kidney", "tissues", "from", "two", "patients", "with", "C0027707#ent", "<e1>", "secondary", "to", "C1527336#ent", "<e2>", "characterized", "by", "indirect", "immunofluorescence", "."], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [21, 22]}}
{"token": ["In", "diseases", "in", "which", "C0027707#ent", "<e1>", "present", ",", "such", "as", "C1527336#ent", "<e2>", "the", "interstitial", "infiltrate", "contribute", "to", "the", "observed", "TC", "dysfunction"], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [10, 11]}}
{"token": ["C1538143#ent", "<e1>", "associated", "with", "histone", "deacetylase-1", "HDAC1", ")", ",", "and", "experiments", "utilizing", "the", "C1422386#ent", "<e2>", "inhibitor", "trichostatin", "A", "that", "LRF-mediated", "repression", "requires", "deacetylase", "activity"], "h": {"id": "C1538143", "name": "C1538143#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1422386", "name": "C1422386#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "investigate", "the", "incidence", "of", "peptic", "ulcers", "a", "population-based", "cohort", "using", "bioequivalent", "C0004057#ent", "<e1>", "80", "mg", ")", "or", "effervescent", "C0054547#ent", "<e2>", "100", "mg", ")", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0054547", "name": "C0054547#ent", "pos": [25, 26]}}
{"token": ["The", "C0282577#ent", "<e1>", "CDG", ")", "syndromes", "are", "a", "group", "of", "C0019247#ent", "<e2>", "invariable", "involvement", "of", "the", "nervous", "system", "severe", "olivopontocerebellar", "atrophy"], "h": {"id": "C0282577", "name": "C0282577#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [10, 11]}}
{"token": ["When", "ION", "occurs", "in", "persons", "less", "than", "50", "years", "of", "age", ",", "such", "etiologies", "as", "C0011854#ent", "<e1>", "antiphospholipid", "antibody-associated", "clotting", "disorders", ",", "C0262428#ent", "<e2>", "and", "migraines", "should", "be", "considered", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0262428", "name": "C0262428#ent", "pos": [22, 23]}}
{"token": ["The", "current", "study", "has", "examined", "C1334507#ent", "<e1>", "expression", "in", "normal", "and", "C0277565#ent", "<e2>", "kidney", "using", "in", "situ", "hybridization", "immunohistochemistry", ",", "and", "Northern", "blotting"], "h": {"id": "C1334507", "name": "C1334507#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [11, 12]}}
{"token": ["In", "3T3-L1", "adipocytes", ",", "Cbl", "binds", "to", "Fyn", "in", "an", "C0011860#ent", "<e1>", "manner", ",", "and", "Cbl", "phosphorylation", "is", "C1540187#ent", "<e2>", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [10, 11]}, "relation": "disease_has_associated_gene", "t": {"id": "C1540187", "name": "C1540187#ent", "pos": [18, 19]}}
{"token": ["There", "was", "also", "evidence", "of", "increased", "oxidative", "stress", "C0064833#ent", "<e1>", "PMNLs", ")", "in", "C0023899#ent", "<e2>", "or", "peripheral", "blood", "rats", "with", "fatty", "livers"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "indicate", "that", "C1709995#ent", "<e1>", "would", "prove", "a", "poor", "diagnostic", "marker", "C0030305#ent", "<e2>", "in", "the", "course", "of", "the", "disease", "."], "h": {"id": "C1709995", "name": "C1709995#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [12, 13]}}
{"token": ["C0065661#ent", "<e1>", "lung", "surfactant", "protein", "A", "other", "ligands", "of", "C1824672#ent", "<e2>", "also", "enhanced", "ingestion", "of", "suboptimally", "opsonized", "IgG-fAbeta", ",", "whereas", "control", "proteins", "not", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1824672", "name": "C1824672#ent", "pos": [9, 10]}}
{"token": ["We", "report", "here", "that", "in", "addition", "to", "C3853644#ent", "<e1>", "at", "least", "one", "other", "member", "of", "the", "src", "family", "C0033681#ent", "<e2>", "p60fyn", ",", "is", "expressed", "in", "platelets", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "these", "seven", "proteins", "are", "probably", "substrates", "of", "C3853644#ent", "<e1>", ",", "although", "they", "may", "be", "substrates", "for", "other", "C0033681#ent", "<e2>", "activated", "by", "C3853644#ent", "<e1>", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [10, 11]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [20, 21]}}
{"token": ["The", "product", "of", "the", "C3853644#ent", "<e1>", "pp60c-src", ")", "is", "a", "C0033681#ent", "<e2>", "is", "expressed", "in", "two", "phases", "of", "neural", "development"], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [10, 11]}}
{"token": ["These", "data", "should", "help", "to", "better", "understand", "the", "molecular", "events", "regulate", "commitment", "to", "a", "C1418943#ent", "<e1>", "C1539479#ent", "<e2>", ",", "mediate", "C1418943#ent", "<e1>", "maintenance", "in", "survival", "niches", "and", "could", "facilitate", "C1418943#ent", "<e1>", "immortalization", "in", "plasma", "cell", "dyscrasias"], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [14, 15]}}
{"token": ["No", "C0442874#ent", "<e1>", "was", "encountered", "in", "four", "patients", "subjected", "to", "the", "C1538440#ent", "<e2>", "regimen", "who", "also", "showed", "complete", "tumor", "regression"], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [11, 12]}}
{"token": ["In", "high", "inhibitor", "titer", "patients", "with", "acute", "hemarthrosis", "both", "C0019069#ent", "<e1>", "hemophilia", "B", ",", "the", "treatment", "consisted", "of", "C0032950#ent", "<e2>", "short", "course", "single", "high", "dose", "of", "PCC", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [18, 19]}}
{"token": ["No", "flush", "occurred", "in", "islets", "exposed", "to", "nutrients", "(", "L-glutamine", "and", "and", "C1881354#ent", "<e1>", ")", "or", "non-nutriet", "secretagogues", "(", "arginine", ",", "C0040374#ent", "<e2>", ",", "theophylline", ")", "."], "h": {"id": "C1881354", "name": "C1881354#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [21, 22]}}
{"token": ["To", "study", "the", "prevalence", "of", "arterial", "diseases", "the", "arteries", "supplying", "the", "lumbar", "spine", "their", "relation", "to", "other", "C0162819#ent", "<e1>", "as", "well", "as", "to", "C0457949#ent", "<e2>"], "h": {"id": "C0162819", "name": "C0162819#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0457949", "name": "C0457949#ent", "pos": [23, 24]}}
{"token": ["Most", "importantly", ",", "fibroblasts", ",", "devoid", "of", "antigen-presenting", "capacity", "peptide", "pulsing", "or", "infection", "with", "rVV-M", ",", "could", "be", "turned", "into", "effective", "C1456795#ent", "<e1>", "after", "infection", "by", "rVV", "encoding", "C0003486#ent", "<e2>", "epitopes", "and", "costimulatory", "molecules"], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [28, 29]}}
{"token": ["Double", "labeling", "experiments", "further", "showed", "that", "C1708300#ent", "<e1>", "was", "expressed", "in", "M\u00fcller", "cells", "stained", "by", "C1415042#ent", "<e2>", "."], "h": {"id": "C1708300", "name": "C1708300#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415042", "name": "C1415042#ent", "pos": [15, 16]}}
{"token": ["The", "C1420703#ent", "<e1>", "of", "the", "NTRK1", "tyrosine", "kinase", "domain", "in-frame", "with", "sequences", "of", "the", "C3273653#ent", "<e2>", "(", "TRK-fused", "gene", ",", "encoding", "a", "protein", "of", "unknown", "function", "."], "h": {"id": "C1420703", "name": "C1420703#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273653", "name": "C3273653#ent", "pos": [14, 15]}}
{"token": ["C0271990#ent", "<e1>", "are", "among", "C0029896#ent", "<e2>", "that", "could", "benefit", "from", "an", "Epo", "gene", "transfer"], "h": {"id": "C0271990", "name": "C0271990#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}}
{"token": ["Atypical", "C0040615#ent", "<e1>", "such", "as", "C0123091#ent", "<e2>", "have", "shown", "good", "efficacy", "in", "treating", "positive", "and", "negative", "symptoms", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0123091", "name": "C0123091#ent", "pos": [5, 6]}}
{"token": ["The", "interaction", "between", "14", "-", "3", "-", "3", "C1419007#ent", "<e1>", "and", "C1706586#ent", "<e2>", "involves", "the", "central", "region", "14", "-", "3", "-", "3", "C1419007#ent", "<e1>", "which", "includes", "a", "motif", "related", "to", "annexins", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419007", "name": "C1419007#ent", "pos": [8, 9]}}
{"token": ["The", "observations", "indicate", "that", "proximal", "renal", "tubular", "acidosis", "C0001126#ent", "<e1>", ")", "induced", "by", "C0065571#ent", "<e2>", "characterized", "by", "impaired", "lumen-to-blood", "transport", "of", "sodium", "bicarbonate", "chloride", "but", "not", "by", "increased", "backflux", "."], "h": {"id": "C0001126", "name": "C0001126#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0065571", "name": "C0065571#ent", "pos": [13, 14]}}
{"token": ["Interestingly", ",", "cis-dienelactone", "and", "2-chloro-cis-dienelactone", "were", "formed", "as", "products", ",", "whereas", "the", "C2987364#ent", "<e1>", "enzyme", "forms", "C0072485#ent", "<e2>", "and", "the", "not", "previously", "isolated", "2-chloroprotoanemonin", ",", "respectively", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0072485", "name": "C0072485#ent", "pos": [16, 17]}}
{"token": ["The", "PXR-SMRT", "interaction", "is", "sensitive", "to", "species-specific", "ligands", ",", "and", "C3890420#ent", "<e1>", "causes", "an", "exchange", "of", "the", "corepressor", "SMRT", "the", "C1334867#ent", "<e2>", "as", "receptor-associated", "coactivator", "3", "RAC3", ")", "."], "h": {"id": "C3890420", "name": "C3890420#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334867", "name": "C1334867#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "a", "third", "type", "of", "protozoan", ",", "C0311386#ent", "<e1>", "Isospora", "hominis", "also", "involved", "in", "the", "occurrence", "of", "severe", "C0012242#ent", "<e2>"], "h": {"id": "C0311386", "name": "C0311386#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012242", "name": "C0012242#ent", "pos": [19, 20]}}
{"token": ["It", "is", "not", "well", "recognized", "how", "disturbances", "in", "the", "local", "metabolism", "some", "C3539947#ent", "<e1>", "especially", "glutamate", "and", "GABA", ",", "may", "lead", "to", "C0036572#ent", "<e2>", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [22, 23]}}
{"token": ["However", ",", "glutathione", ",", "which", "is", "a", "non-phenolic", "antioxidant", "that", "acts", "as", "a", "hydrogen", "donor", "for", "C0017822#ent", "<e1>", "could", "not", "suppress", "lipid", "peroxidation", "the", "presence", "of", "C3889156#ent", "<e2>", "."], "h": {"id": "C0017822", "name": "C0017822#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3889156", "name": "C3889156#ent", "pos": [26, 27]}}
{"token": ["C1333356#ent", "<e1>", "DNA", "helicases", "XPB", "and", "C0268138#ent", "<e2>", ",", "are", "also", "components", "in", "this", "apoptotic", "pathway"], "h": {"id": "C1333356", "name": "C1333356#ent", "pos": [0, 1]}, "relation": "gene_associated_with_disease", "t": {"id": "C0268138", "name": "C0268138#ent", "pos": [6, 7]}}
{"token": ["Characterization", "of", "PIP1", "revealed", "that", "it", "is", "a", "C1314754#ent", "<e1>", "related", "to", "Rcr3", ",", "a", "tomato", "C1705065#ent", "<e2>", "functions", "in", "fungal", "resistance", "."], "h": {"id": "C1314754", "name": "C1314754#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [16, 17]}}
{"token": ["The", "hexose", "bisphosphate", "activation", "of", "C0031653#ent", "<e1>", "was", "investigated", "with", "both", "plant", "(", "C1572795#ent", "<e2>", "and", "mung", "bean", "and", "animal", "(", "rabbit", "muscle", "sources", "of", "the", "enzyme", "."], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1572795", "name": "C1572795#ent", "pos": [13, 14]}}
{"token": ["The", "current", "in", "vitro", "studies", "examined", "the", "potential", "of", "C0000598#ent", "<e1>", "to", "undergo", "a", "similar", "conversion", "by", "cytochrome", "P450", "C0534137#ent", "<e2>", ")", ",", "peroxidases", ",", "and", "monoamine", "oxidase", "MAO", ")", "."], "h": {"id": "C0000598", "name": "C0000598#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [19, 20]}}
{"token": ["Adverse", "events", "reported", "by", "three", "subjects", "in", "the", "ramelteon", "group", ":", "C0270697#ent", "<e1>", "(", "n", "=", "2", ")", "and", "C0042029#ent", "<e2>", "n", "=", "1", ")", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [19, 20]}}
{"token": ["C0012373#ent", "<e1>", "(", "300", "micrograms/kg", ")", "decreased", "total", "peripheral", "resistance", "C1420877#ent", "<e2>", ")", "and", "MCP", "significantly", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420877", "name": "C1420877#ent", "pos": [10, 11]}}
{"token": ["Two", "novel", "C3540790#ent", "<e1>", ",", "NAD+-linked", "L-alloisocitrate", "(", "erythro-Ls-isocitrate", ")", "dehydrogenase", "and", "C2697821#ent", "<e2>", "were", "found", "and", "purified", "from", "a", "strain", "of", "Pseudomonas", "isolated", "as", "an", "L-alloisocitrate", "utilizing", "bacterium", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2697821", "name": "C2697821#ent", "pos": [12, 13]}}
{"token": ["Ewing's", "sarcoma", "associated", "with", "fusion", "between", "the", "EWS", "and", "C1705749#ent", "<e1>", "genes", ",", "forming", "an", "C3274607#ent", "<e2>"], "h": {"id": "C1705749", "name": "C1705749#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3274607", "name": "C3274607#ent", "pos": [15, 16]}}
{"token": ["The", "giant", "magnetoresistance", "C1704695#ent", "<e1>", ")", "responses", "for", "both", "the", "rings", "exhibit", "distinct", "C0017373#ent", "<e2>", "fields", "and", "features", "corresponding", "to", "identifiable", "magnetization", "states", "in", "different", "segments", "of", "the", "nanostructures", "."], "h": {"id": "C1704695", "name": "C1704695#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017373", "name": "C0017373#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "chronic", "treatment", "C0246203#ent", "<e1>", "not", "only", "improves", "endothelial", "but", "also", "vascular", "smooth", "muscle", "function", "C0020476#ent", "<e2>", ",", "which", "may", "contribute", "to", "the", "beneficial", "clinical", "effects", "statins", "."], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [16, 17]}}
{"token": ["Inhibitors", "for", "C0089793#ent", "<e1>", "mammalian", "target", "of", "rapamycin", ",", "and", "C0380051#ent", "<e2>", "to", "block", "NO", "donor-induced", "IRS-1", "reduction", ",", "whereas", "these", "inhibitors", "prevented", "insulin-stimulated", "IRS-1", "decrease", "."], "h": {"id": "C0089793", "name": "C0089793#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [10, 11]}}
{"token": ["C0907533#ent", "<e1>", "overexpression", "of", "C2826583#ent", "<e2>", "or", "RCN2", "in", "Arabidopsis", "caused", "a", "late-flowering", "and", "highly", "branching", "phenotype", ",", "indicating", "that", "they", "possess", "conserved", "biochemical", "functions", "TFL1", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2826583", "name": "C2826583#ent", "pos": [4, 5]}}
{"token": ["Kimura's", "disease", "KD", ")", "mimicking", "C0206141#ent", "<e1>", "is", "an", "immune", "mediated", "C0029877#ent", "<e2>", "usually", "involves", "the", "head", "and", "neck", "region", "primarily", "affecting", "the", "salivary", "glands", "adjacent", "muscle", "regional", "lymph", "nodes"], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [11, 12]}}
{"token": ["C0154723#ent", "<e1>", "is", "considered", "a", "C0042373#ent", "<e2>", "dilatation", "of", "cerebral", "arteries"], "h": {"id": "C0154723", "name": "C0154723#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [5, 6]}}
{"token": ["The", "light-dependent", "regulation", "of", "C0004199#ent", "<e1>", "activity", "is", "carried", "out", "in", "part", "through", "redox", "modulation", "a", "C0010637#ent", "<e2>", "CF1", "gamma-subunit", "."], "h": {"id": "C0004199", "name": "C0004199#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010637", "name": "C0010637#ent", "pos": [16, 17]}}
{"token": ["Results", "suggest", "that", "TP-5", "is", "not", "the", "smallest", "active", "fragment", "thymopoietins", ",", "since", "peptides", "(", "C0075032#ent", "<e1>", "and", "TP-4", ")", "exhibit", "similar", "or", "higher", "C3537335#ent", "<e2>", "activation", "on", "E-receptor", "."], "h": {"id": "C0075032", "name": "C0075032#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3537335", "name": "C3537335#ent", "pos": [24, 25]}}
{"token": ["C3812693#ent", "<e1>", "has", "been", "reported", "to", "be", "upregulated", "following", "C1332793#ent", "<e2>", "administration", "."], "h": {"id": "C3812693", "name": "C3812693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332793", "name": "C1332793#ent", "pos": [9, 10]}}
{"token": ["The", "results", "indicate", "the", "'", "high", "Man", "'", "structure", "generated", "by", "C0089266#ent", "<e1>", "may", "constitute", "potential", "novel", "mechanism", "for", "ER", "stress", "C0911469#ent", "<e2>", "cell", "apoptosis"], "h": {"id": "C0089266", "name": "C0089266#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0911469", "name": "C0911469#ent", "pos": [21, 22]}}
{"token": ["C0085399#ent", "<e1>", "must", "be", "included", "in", "the", "differential", "diagnosis", "C0011991#ent", "<e2>", "endemic", "areas", "because", "delay", "in", "therapy", "allows", "complications", "and", "sometimes", "death"], "h": {"id": "C0085399", "name": "C0085399#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [9, 10]}}
{"token": ["These", "osteoclast-like", "cells", "from", "monocytes", "contained", "C0297331#ent", "<e1>", "and", "caused", "the", "resorption", "of", "the", "C0011407#ent", "<e2>", "in", "vitro"], "h": {"id": "C0297331", "name": "C0297331#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011407", "name": "C0011407#ent", "pos": [14, 15]}}
{"token": ["In", "10", "patients", ",", "C0026289#ent", "<e1>", "was", "administered", "during", "C0039240#ent", "<e2>"], "h": {"id": "C0026289", "name": "C0026289#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0039240", "name": "C0039240#ent", "pos": [9, 10]}}
{"token": ["For", "this", "purpose", ",", "the", "long", "chain", "triglyceride", "C1416808#ent", "<e1>", ")", "solubility", "and", "affinity", "to", "chylomicrons", "ex", "vivo", "both", "C0006864#ent", "<e2>", "were", "evaluated", "."], "h": {"id": "C1416808", "name": "C1416808#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006864", "name": "C0006864#ent", "pos": [19, 20]}}
{"token": ["To", "do", "this", "we", "have", "expressed", "a", "temperature", "sensitive", "abl", "C1705341#ent", "<e1>", "in", "a", "C0812325#ent", "<e2>", ",", "multipotent", "stem", "cell", "line", "FDCP-Mix", ")", "in", "which", "growth", "is", "normally", "suppressed", "by", "MIP-1alpha", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [14, 15]}}
{"token": ["The", "focal", "adhesion", "FAK", ")", "non-receptor", "protein-tyrosine", "kinase", "C1705341#ent", "<e1>", ")", "links", "both", "extracellular", "matrix/integrin", "C0812325#ent", "<e2>", "stimulation", "to", "intracellular", "signals", "promoting", "cell", "migration"], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [15, 16]}}
{"token": ["More", "recently", ",", "pulmonary", "hypertension", "been", "described", "in", "some", "patients", "taking", "other", "amphetamine-like", ",", "C0003123#ent", "<e1>", "fenfluramine", "and", "its", "d-isomer", ",", "C2350698#ent", "<e2>", "."], "h": {"id": "C0003123", "name": "C0003123#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2350698", "name": "C2350698#ent", "pos": [21, 22]}}
{"token": ["The", "protein", "tyrosine", "kinase", "inhibitors", "as", "genistein", "and", "C0213654#ent", "<e1>", "reduced", "IFN-r", "plus", "LPS-induced", "C1417760#ent", "<e2>", "mRNA", "expression", "and", "NO", "production", "."], "h": {"id": "C0213654", "name": "C0213654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [14, 15]}}
{"token": ["Urinary", "levels", "trans", ",", "trans-muconic", "acid", "and", "of", "C0031428#ent", "<e1>", ",", "catechol", "and", "hydroquinone", "(", "free", "and", "conjugated", "with", "C0038719#ent", "<e2>", "and", "glucuronic", "group", "were", "measured", "by", "high-performance", "liquid", "chromatography", "HPLC", ")", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038719", "name": "C0038719#ent", "pos": [19, 20]}}
{"token": ["Perturbation", "of", "this", "signaling", "pathway", "inhibition", "of", "C1335404#ent", "<e1>", "LPP-1", ")", "by", "propranolol", "or", "inhibition", "of", "the", "C0031670#ent", "<e2>", "PA", ")", "formation", "by", "PLD", "with", "a", "primary", "alcohol", "significantly", "attenuated", "platelet", "activation", "PAR1-AP", "."], "h": {"id": "C1335404", "name": "C1335404#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031670", "name": "C0031670#ent", "pos": [17, 18]}}
{"token": ["PPARgamma", "knockdown", "paradoxically", "did", "not", "attenuate", "the", "stimulation", "of", "the", "endogenous", "C1419338#ent", "<e1>", "expression", "by", "C0289313#ent", "<e2>", "."], "h": {"id": "C1419338", "name": "C1419338#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [15, 16]}}
{"token": ["These", "results", "indicate", "that", ",", "in", "rats", ",", "C3537334#ent", "<e1>", "is", "expressed", "C0907533#ent", "<e2>", "and", "is", "particularly", "inducible", "in", "the", "small", "intestine"], "h": {"id": "C3537334", "name": "C3537334#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [12, 13]}}
{"token": ["Only", "substrates", "with", "C2699403#ent", "<e1>", ",", "4-linkages", "can", "serve", "as", "C0017768#ent", "<e2>", "donors", "for", "transferase", "reactions"], "h": {"id": "C2699403", "name": "C2699403#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017768", "name": "C0017768#ent", "pos": [10, 11]}}
{"token": ["C0023660#ent", "<e1>", "should", "probably", "be", "administered", "to", "all", "uncomplicated", "C0155626#ent", "<e2>", "patients", "during", "the", "first", "48", "hours", "after", "infarction", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [9, 10]}}
{"token": ["The", "purified", "Rab", "GG", "transferase", "not", "attach", "C0138843#ent", "<e1>", "to", "p21H-ras-CVLL", ",", "which", "is", "prenylated", "by", "a", "C0040676#ent", "<e2>", "the", "CAAX", "type", "that", "resembles", "the", "CAAX", "farnesyltransferase"], "h": {"id": "C0138843", "name": "C0138843#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0040676", "name": "C0040676#ent", "pos": [17, 18]}}
{"token": ["Pyridinyl", "and", "pyrimidinyl", "imidazoles", "selectively", "inhibit", "p38alpha", "C0752312#ent", "<e1>", "are", "useful", "in", "the", "treatment", "of", "inflammatory", "diseases", "C0003873#ent", "<e2>"], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}}
{"token": ["The", "nonpeptide", "inhibitors", "C0052553#ent", "<e1>", "and", "L-364,718", ",", "inhibited", "pepsinogen", "secretion", "identical", "C1839576#ent", "<e2>", "values", "for", "antagonism", "of", "both", "CCK", "and", "gastrin", ",", "indicating", "that", "both", "peptides", "interact", "with", "the", "same", "functional", "receptor"], "h": {"id": "C0052553", "name": "C0052553#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [12, 13]}}
{"token": ["Comparison", "of", "results", "for", "methyl", "ribosides", "C0017764#ent", "<e1>", "with", "results", "for", "corresponding", "C0007906#ent", "<e2>", "substrates", "suggests", "that", "both", "should", "hydrolyze", "through", "an", "A-1", "mechanism", "."], "h": {"id": "C0017764", "name": "C0017764#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007906", "name": "C0007906#ent", "pos": [12, 13]}}
{"token": ["Recently", ",", "a", "third", "gene", "C3538757#ent", "<e1>", ",", "was", "discovered", "as", "a", "cause", "of", "familial", "hemiplegic", "migraine", "C1832884#ent", "<e2>", ")", "."], "h": {"id": "C3538757", "name": "C3538757#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1832884", "name": "C1832884#ent", "pos": [17, 18]}}
{"token": ["However", ",", "the", "effect", "of", "C1538973#ent", "<e1>", "inhibition", "on", "delayed", "C0751495#ent", "<e2>", "improve", "our", "understanding", "of", "the", "role", "of", "NO", "during", "this", "phase", "."], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [10, 11]}}
{"token": ["C1427216#ent", "<e1>", "was", "slightly", "susceptible", "to", "C0085752#ent", "<e2>", "toxicity", "as", "compared", "to", "CL7", "."], "h": {"id": "C1427216", "name": "C1427216#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [6, 7]}}
{"token": ["However", ",", "response", "rates", "patients", "with", "C0020474#ent", "<e1>", "higher", "for", "C0033228#ent", "<e2>", ",", "which", "led", "to", "a", "substantial", "cost", "advantage", "for", "this", "agent", "(", "DM768", "for", "C0033228#ent", "<e2>", ",", "DM2080", "for", "simvastatin", ")", "."], "h": {"id": "C0020474", "name": "C0020474#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [10, 11]}}
{"token": ["In", "summary", ",", "C1420603#ent", "<e1>", "appears", "to", "act", "downstream", "of", "C1825969#ent", "<e2>", "and", "Delta/Notch", "signaling", "to", "maintain", "the", "separation", "of", "anterior", "and", "posterior", "somite", "compartments", "."], "h": {"id": "C1420603", "name": "C1420603#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1825969", "name": "C1825969#ent", "pos": [10, 11]}}
{"token": ["The", "basic", "helix-loop-helix", "leucine", "zipper", "bHLHZIP", ")", "protein", "C1336608#ent", "<e1>", "and", "Smad3", "synergistically", "activate", "transcription", "of", "the", "plasminogen", "activator", "inhibitor-1", "C1705527#ent", "<e2>", ")", "as", "well", "as", "other", "genes", "."], "h": {"id": "C1336608", "name": "C1336608#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705527", "name": "C1705527#ent", "pos": [20, 21]}}
{"token": ["Experiments", "using", "the", "M2", "inhibitor", "C0035629#ent", "<e1>", "and", "a", "C0206526#ent", "<e2>", "mutant", "of", "M2", "established", "that", "the", "ion", "channel", "activity", "M2", "was", "important", "for", "M2-dependent", "augmentation", "of", "vector", "production"], "h": {"id": "C0035629", "name": "C0035629#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0206526", "name": "C0206526#ent", "pos": [9, 10]}}
{"token": ["Butalbital", ",", "ergot", "alkaloids", "C0080151#ent", "<e1>", ",", "and", "narcotic", "and", "oral", "or", "C0039052#ent", "<e2>", "often", "abused", "."], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039052", "name": "C0039052#ent", "pos": [12, 13]}}
{"token": ["Multiple", "endocrine", "neoplasia", "type", "2", "MEN", "2", ")", "is", "a", "rare", "C1848862#ent", "<e1>", "of", "medullary", "thyroid", "carcinoma", "MTC", ")", "with", "pheochromocytoma", "and/or", "C0221002#ent", "<e2>", "PHP", ")", ",", "usually", "due", "to", "multigland", "hyperplasia", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [22, 23]}}
{"token": ["C0035258#ent", "<e1>", "follows", "a", "circadian", "rhythm", "is", "relieved", "clinically", "by", "C0178601#ent", "<e2>"], "h": {"id": "C0035258", "name": "C0035258#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0178601", "name": "C0178601#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "from", "these", "data", "that", "p97", ",", "C1417857#ent", "<e1>", "and", "perhaps", "other", "related", "C0001473#ent", "<e2>", "catalyse", "rapid", "and", "complete", "fusion", "between", "lipid", "bilayers", "opposing", "membranes", "."], "h": {"id": "C1417857", "name": "C1417857#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [14, 15]}}
{"token": ["In", "the", "C0015131#ent", "<e1>", "group", ",", "cortisol", "concentrations", "significantly", "lower", "at", "H0", ",", "C1424771#ent", "<e2>", "and", "H6", ";", "aldosterone", "concentrations", "were", "also", "significantly", "lower", "than", "control", "values", "throughout", "the", "study", "period", "."], "h": {"id": "C0015131", "name": "C0015131#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1424771", "name": "C1424771#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "C0282109#ent", "<e1>", "or", "regulatory", "subunit", "be", "solubilized", "either", "by", "C0146951#ent", "<e2>", "high", "pH", "or", "trypsin", "treatment", "."], "h": {"id": "C0282109", "name": "C0282109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [12, 13]}}
{"token": ["One", "failure", "was", "related", "to", "unrecognized", "C0030846#ent", "<e1>", "shown", "by", "C1420002#ent", "<e2>", "."], "h": {"id": "C0030846", "name": "C0030846#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420002", "name": "C1420002#ent", "pos": [10, 11]}}
{"token": ["The", "dose", "of", "40", "mg/kg", "that", "induced", "C4281785#ent", "<e1>", "to", "a", "weak", "C0087140#ent", "<e2>", "expression", "in", "the", "medial", "thalamus", "some", "cortical", "areas", "globus", "pallidus"], "h": {"id": "C4281785", "name": "C4281785#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [12, 13]}}
{"token": ["The", "initial", "middle", "ear", "disease", "from", "acute", "C0029882#ent", "<e1>", "C0029882#ent", "<e1>", "effusion", "in", "2", ",", "acute", "otitis", "media", "or", "C0701825#ent", "<e1>", "1", "each", ",", "and", "C0029882#ent", "<e1>", "effusion", "in", "the", "remaining", "8", "patients", "."], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0701825", "name": "C0701825#ent", "pos": [19, 20]}}
{"token": ["Prolonged", "C0029882#ent", "<e1>", "gradually", "replacing", "classic", "C0701825#ent", "<e2>"], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0701825", "name": "C0701825#ent", "pos": [6, 7]}}
{"token": ["No", "clinical", "or", "C1121259#ent", "<e1>", "noted", "in", "plaque", "or", "C0017574#ent", "<e2>", "the", "group", "receiving", "chlorhexidine", "treatment", "during", "the", "6-month", "period", "."], "h": {"id": "C1121259", "name": "C1121259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017574", "name": "C0017574#ent", "pos": [9, 10]}}
{"token": ["C0022564#ent", "<e1>", "and", "CKER", "were", "found", "in", "both", "C0047123#ent", "<e2>", "and", "CPC", ",", "but", "may", "be", "useful", "in", "the", "distinction", "from", "ependymomas", "."], "h": {"id": "C0022564", "name": "C0022564#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0047123", "name": "C0047123#ent", "pos": [8, 9]}}
{"token": ["To", "compare", "the", "effectiveness", "of", "cyclosporine", "solution", "triamcinolone", "acetonide", "C0067320#ent", "<e1>", "in", "the", "treatment", "of", "C0206139#ent", "<e2>", "OLP", ")", "in", "reducing", "signs", "and", "symptoms", "."], "h": {"id": "C0067320", "name": "C0067320#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0206139", "name": "C0206139#ent", "pos": [15, 16]}}
{"token": ["The", "chromatin", "structures", "the", "C0087071#ent", "<e1>", "and", "subtelomeric", "regions", "on", "chromosomal", "DNA", "molecules", "Saccharomyces", "cerevisiae", "analyzed", "using", "C0025965#ent", "<e2>", "DNAse", "I.", "The", "subtelomeric", "repeats", "X", "and", "Y", "'", "were", "assembled", "in", "nucleosomes", "."], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025965", "name": "C0025965#ent", "pos": [17, 18]}}
{"token": ["Biting", "insects", "sampled", "to", "investigate", "the", "cause(s", ")", "of", "C0011603#ent", "<e1>", "(", "putative", "Culicoides", "hypersensitivity", "[", "C1537630#ent", "<e2>", "]", ")", "on", "horses", "on", "the", "Palos", "Verdes", "Peninsula", ",", "Los", "Angeles", "County", "California", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1537630", "name": "C1537630#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "summarize", "current", "knowledge", "of", "the", "contribution", "of", "nitric", "oxide", "NO", ")", "to", "C0011603#ent", "<e1>", "special", "focus", "on", "C1537630#ent", "<e2>", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1537630", "name": "C1537630#ent", "pos": [19, 20]}}
{"token": ["Results", "indicate", "no", "statistically", "significant", "changes", "in", "the", "concentrations", "of", "C1416805#ent", "<e1>", ",", "Chl", "a", ",", "or", "C1420044#ent", "<e2>", "in", "the", "spring", "or", "summer", "from", "1981", "to", "1993", "."], "h": {"id": "C1416805", "name": "C1416805#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420044", "name": "C1420044#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "stromal", "cells", "C0033501#ent", "<e1>", "a", "dual", "inhibitor", "lipoxygenase", "and", "cyclooxygenase", "C3541394#ent", "<e2>", ",", "did", "not", "affect", "the", "ability", "of", "arachidonic", "acid", "induce", "JNK", "activation", "."], "h": {"id": "C0033501", "name": "C0033501#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [12, 13]}}
{"token": ["Longer", "C0720099#ent", "<e1>", "of", "monotherapy", "amplified", "between-group", "differences", "in", "C0018801#ent", "<e2>"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [9, 10]}}
{"token": ["DDATHF", "is", "a", "potent", "C0016411#ent", "<e1>", "suppresses", "purine", "synthesis", "direct", "or", "indirect", "inhibition", "of", "C0070929#ent", "<e2>"], "h": {"id": "C0016411", "name": "C0016411#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0070929", "name": "C0070929#ent", "pos": [14, 15]}}
{"token": ["C0024535#ent", "<e1>", "malaria", "in", "a", "C0455988#ent", "<e2>", "patient", "is", "an", "emergency", "requiring", "immediate", "treatment", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [5, 6]}}
{"token": ["Acute", "renal", "failure", "a", "frequent", "and", "serious", "complication", "of", "C0024535#ent", "<e1>", "malaria", "in", "C0455988#ent", "<e2>", "adults", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [13, 14]}}
{"token": ["To", "maintain", "C3536838#ent", "<e1>", "efficacy", "the", "percentage", "of", "C0018889#ent", "<e2>", "in", "refugia", "must", "be", "sufficiently", "large", "."], "h": {"id": "C3536838", "name": "C3536838#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [8, 9]}}
{"token": ["Progressive", "carboxyl-terminal", "truncations", "of", "the", "C0001156#ent", "<e1>", "transcribed", "and", "translated", "to", "yield", "C1305923#ent", "<e2>", "with", "the", "same", "amino", "terminus", "but", "lacking", "varying", "amounts", "of", "the", "carboxyl", "terminus"], "h": {"id": "C0001156", "name": "C0001156#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}}
{"token": ["Mannan-binding", "lectin-associated", "serine", "protease-2", "C1705061#ent", "<e1>", ")", "is", "a", "C0036734#ent", "<e2>", "in", "the", "activation", "of", "lectin", "complement", "pathway"], "h": {"id": "C1705061", "name": "C1705061#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [9, 10]}}
{"token": ["Ciprofloxacin", "is", "also", "effective", "in", "a", "range", "of", "other", "indications", "(", "e.g.", "C0015403#ent", "<e1>", "skin", "and", "C0149778#ent", "<e2>", "bone", "and", "joint", "infections", "and", "gonorrhoea", ")", "."], "h": {"id": "C0015403", "name": "C0015403#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0149778", "name": "C0149778#ent", "pos": [16, 17]}}
{"token": ["Membranous", "nephropathy", "MN", ")", "is", "an", "uncommon", "and", "usually", "secondary", "cause", "of", "C1704321#ent", "<e1>", "children", ",", "and", "has", "been", "reported", "after", "C0149516#ent", "<e2>", "antigenemia", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0149516", "name": "C0149516#ent", "pos": [21, 22]}}
{"token": ["The", "effect", "of", "IBMX", "was", "not", "altered", "by", "pretreating", "the", "cells", "with", "C0043167#ent", "<e1>", "by", "including", "either", "cAMP", "or", "C1449702#ent", "<e2>", "the", "intracellular", "solution"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1449702", "name": "C1449702#ent", "pos": [19, 20]}}
{"token": ["We", "have", "previously", "shown", "that", "administration", "of", "lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "4", "h", "before", "C0178540#ent", "<e2>", "(", "HI", ")", "increases", "brain", "injury", "7-d-old", "rats", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0178540", "name": "C0178540#ent", "pos": [15, 16]}}
{"token": ["The", "C0039613#ent", "<e1>", "effect", "of", "C0115656#ent", "<e2>", "was", "measured", "in", "vivo", "application", "of", "the", "transdermal", "systems"], "h": {"id": "C0039613", "name": "C0039613#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0115656", "name": "C0115656#ent", "pos": [5, 6]}}
{"token": ["C1175029#ent", "<e1>", "(", "Pargluva", ")", ",", "a", "C4054191#ent", "<e2>", "has", "both", "glucose-", "and", "lipid-lowering", "effects", "in", "animal", "models", "in", "patients", "with", "diabetes", "."], "h": {"id": "C1175029", "name": "C1175029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4054191", "name": "C4054191#ent", "pos": [7, 8]}}
{"token": ["C1175029#ent", "<e1>", "(", "Pargluva", ";", "Bristol-Myers", "Squibb", ")", ",", "a", "C4054191#ent", "<e2>", "is", "under", "development", "for", "treatment", "of", "type", "2", "diabetes"], "h": {"id": "C1175029", "name": "C1175029#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4054191", "name": "C4054191#ent", "pos": [10, 11]}}
{"token": ["The", "neonatal", "phenotype", "of", "C0342791#ent", "<e1>", "characterized", "by", "hypoketotic", "hypoglycaemia", "C0220994#ent", "<e2>", ",", "cardiomyopathy", "and", "skeletal", "muscle", "weakness", "in", "early", "death"], "h": {"id": "C0342791", "name": "C0342791#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0220994", "name": "C0220994#ent", "pos": [10, 11]}}
{"token": ["The", "diagnosis", "of", "C1840428#ent", "<e1>", "previously", "described", "by", "our", "group", "as", "an", "C2936739#ent", "<e2>", "trait", ",", "was", "unmistakable", ",", "thus", "permitting", "the", "corroboration", "of", "this", "genodermatosis", "."], "h": {"id": "C1840428", "name": "C1840428#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [12, 13]}}
{"token": ["Elevated", "C0001942#ent", "<e1>", "can", "therefore", "explain", "most", "of", "the", "decrease", "in", "4HC-induced", "C1423825#ent", "<e2>", ",", "with", "elevated", "GSH", "levels", "probably", "accounting", "for", "the", "remaining", "small", "increment", "of", "resistance", "."], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1423825", "name": "C1423825#ent", "pos": [12, 13]}}
{"token": ["C0162671#ent", "<e1>", ",", "a", "syndrome", "characterized", "by", "C0026848#ent", "<e2>", ",", "Encephalopathy", ",", "Lactic", "Acidosis", "Stroke-like", "episodes", "is", "one", "of", "a", "group", "of", "diseases", "known", "as", "mitochondrial", "encephalopathies"], "h": {"id": "C0162671", "name": "C0162671#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [7, 8]}}
{"token": ["Among", "the", "many", "host", "genes", "induced", "by", "C0042769#ent", "<e1>", "interferon", ",", "the", "eIF2alpha", "protein", "kinase", "C1705329#ent", "<e2>", "and", "the", "2'-5'", "oligoadenylate", "synthetase", "OAS", ")", "are", "both", "activated", "by", "double-stranded", "RNA", "dsRNA", ")", "produced", "in", "virus-infected", "cells", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705329", "name": "C1705329#ent", "pos": [15, 16]}}
{"token": ["Treatment", "with", "a", "combination", "of", "C0033497#ent", "<e1>", "and", "a", "synthetic", "angiotensin-II", "competitive", "inhibitor", "(", "C1705884#ent", "<e2>", ")", "produced", "no", "further", "improvement", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705884", "name": "C1705884#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "ponies", "in", "clinical", "remission", "C3714496#ent", "<e1>", "are", "not", "hyperreactive", "to", "aerosols", "of", "C0600370#ent", "<e2>", "or", "citric", "acid"], "h": {"id": "C3714496", "name": "C3714496#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "effects", "of", "angiotensin-converting", "enzyme", "ACE", ")", "inhibitors", "and", "statins", "(", "hydroxy-methyl-glutaryl-CoA", "C2936788#ent", "<e1>", "on", "inflammatory", "markers", "endothelial", "functions", "patients", "with", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C2936788", "name": "C2936788#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [23, 24]}}
{"token": ["Amebic", "dysentery", "C0004692#ent", "<e1>", "are", "examples", "of", "C0043528#ent", "<e2>", "waterborne", "infections", ",", "though", "human-to-human", "transmission", "can", "occur", "."], "h": {"id": "C0004692", "name": "C0004692#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [7, 8]}}
{"token": ["The", "C1420705#ent", "<e1>", "ORF-3a", "gene", "encodes", "72", "C3539946#ent", "<e2>", "however", ",", "a", "37", "nucleotide", "deletion", "found", "16", "nucleotides", "downstream", "of", "the", "C1420705#ent", "<e1>", "ORF-3a", "stop", "codon.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1420705", "name": "C1420705#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [7, 8]}}
{"token": ["Twenty-four", "of", "the", "44", "patients", "with", "prominent", "SAH", "on", "the", "computed", "tomographic", "CT", ")", "scan", ",", "anticipating", "to", "develop", "C0917798#ent", "<e1>", "to", "vasospasm", ",", "were", "given", "C0012963#ent", "<e2>", "(", "DOB", ")", "."], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0012963", "name": "C0012963#ent", "pos": [26, 27]}}
{"token": ["The", "hypochloride-induced", "activation", "of", "C1567710#ent", "<e1>", "was", "prevented", "by", "C1504945#ent", "<e2>", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [4, 5]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C1504945", "name": "C1504945#ent", "pos": [9, 10]}}
{"token": ["There", "was", "marked", "activation", "of", "C1567710#ent", "<e1>", "in", "the", "ischemic/reperfused", "myocardium", ",", "which", "was", "blocked", "by", "C1504945#ent", "<e2>", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [5, 6]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C1504945", "name": "C1504945#ent", "pos": [16, 17]}}
{"token": ["A", "further", "aim", "was", "to", "elucidate", "whether", "longitudinal", "changes", "mandibular", "radiographic", "characteristics", "and", "the", "bucco-lingual", "dimension", "of", "the", "C0002382#ent", "<e1>", "related", "to", "alterations", "of", "C1826421#ent", "<e2>", "."], "h": {"id": "C0002382", "name": "C0002382#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1826421", "name": "C1826421#ent", "pos": [24, 25]}}
{"token": ["Cerebral", "autosomal", "dominant", "arteriopathy", "with", "subcortical", "infarcts", "leukoencephalopathy", "(", "C3813553#ent", "<e1>", ")", "is", "an", "inherited", "C3275121#ent", "<e2>", "stroke", "and", "subcortical", "vascular", "dementia"], "h": {"id": "C3813553", "name": "C3813553#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [15, 16]}}
{"token": ["Cerebral", "autosomal", "dominant", "arteriopathy", "with", "subcortical", "infarcts", "leukoencephalopathy", "(", "C3813553#ent", "<e1>", ")", "is", "a", "hereditary", "form", "of", "C3275121#ent", "<e2>", "which", "the", "pons", "may", "show", "lacunar", "infarcts", "leukoaraiosis", "."], "h": {"id": "C3813553", "name": "C3813553#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3275121", "name": "C3275121#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "a", "course", "administration", "of", "glucocorticoids", "to", "C0019101#ent", "<e1>", "patients", "is", "justified", "only", "in", "severe", "collapses", "and", "C0020635#ent", "<e2>", "by", "the", "laboratory", "methods"], "h": {"id": "C0019101", "name": "C0019101#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020635", "name": "C0020635#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "the", "expression", "of", "HLA-DR", "antigens", "not", "required", "for", "C4049859#ent", "<e1>", "and", "IL-1", "production", "in", "response", "to", "C0026249#ent", "<e2>", "."], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [18, 19]}}
{"token": ["The", "sensitive", "alleles", "for", "C4284041#ent", "<e1>", ",", "CM", ",", "and", "TC", "were", "shown", "to", "be", "C0017361#ent", "<e2>", "to", "the", "resistance", "alleles"], "h": {"id": "C4284041", "name": "C4284041#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [15, 16]}}
{"token": ["C1709313#ent", "<e1>", "depended", "on", "wild-type", "p53", "to", "induce", "C1332411#ent", "<e2>", "and", "activate", "the", "death", "program"], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332411", "name": "C1332411#ent", "pos": [8, 9]}}
{"token": ["Six", "patients", "with", "IgA", "nephropathy", "four", "patients", "with", "C0017662#ent", "<e1>", "four", "patients", "with", "rapidly", "progressive", "C0017658#ent", "<e2>", "and", "six", "patients", "with", "diabetic", "nephropathy", "examined", "."], "h": {"id": "C0017662", "name": "C0017662#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [15, 16]}}
{"token": ["Acute", ",", "subacute", ",", "and", "C0017662#ent", "<e1>", "similar", "in", "certain", "features", "to", "C0017658#ent", "<e2>", "has", "been", "produced", "in", "rabbits", "by", "repeated", "injections", "of", "bovine", "serum", "albumin", "."], "h": {"id": "C0017662", "name": "C0017662#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", "we", "measured", "the", "myocardial", "concentration", "of", "ATP", ",", "ADP", ",", "lactate", "and", "16", "different", "C3539946#ent", "<e1>", "left", "ventricular", "biopsies", "collected", "from", "patients", "with", "C1260873#ent", "<e2>", "from", "patients", "with", "ischaemic", "heart", "disease"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1260873", "name": "C1260873#ent", "pos": [26, 27]}}
{"token": ["We", "assessed", "the", "clinical", "utility", "of", "C0003596#ent", "<e1>", "infusional", "therapy", "patients", "with", "C0030567#ent", "<e2>", "and", "motor", "fluctuations", "sought", "evidence", "for", "alterations", "in", "drug", "response", "from", "chronic", "treatment"], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [12, 13]}}
{"token": ["Pain", "and", "condition-specific", "symptoms", "were", "assessed", "using", "a", "standard", "visual", "analog", "scale", "VAS", ")", ",", "an", "abridged", "C0003864#ent", "<e1>", "impact", "measurement", "scale", "(", "AIMS2", ")", "and", "the", "C0016053#ent", "<e2>", "impact", "questionnaire", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0016053", "name": "C0016053#ent", "pos": [27, 28]}}
{"token": ["The", "death", "of", "a", "23-year-old", "man", "resulting", "from", "C0012265#ent", "<e1>", "toxicity", "and", "C0018801#ent", "<e2>", "attributed", "to", "ingestion", "of", "a", "West", "Indian", "aphrodisiac", "known", "as", "\"", "Love", "Stone"], "h": {"id": "C0012265", "name": "C0012265#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}}
{"token": ["The", "catalytic", "subunit", "human", "Cl", ",", "Cls-Clr-Clr-Cls", ",", "is", "a", "C1413043#ent", "<e1>", "+", "-dependent", "tetrameric", "association", "of", "two", "serine", "proteases", "Clr", "and", "C0265252#ent", "<e2>", ",", "which", "are", "glycoproteins", "containing", "asparagine-linked", "carbohydrates", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0265252", "name": "C0265252#ent", "pos": [22, 23]}}
{"token": ["The", "amyloid", "in", "senile", "plaques", "mainly", "composed", "of", "the", "amyloid", "beta-peptide", "A", "beta", ")", "of", "39", "-", "43", "C3539946#ent", "<e1>", "from", "a", "larger", "C1364818#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [23, 24]}}
{"token": ["The", "second", "enzyme", ",", "Atu", "I", "a", "C0011524#ent", "<e1>", "generated", "the", "identical", "DNA", "digestion", "as", "EcoRII", "when", "several", "C0011519#ent", "<e2>", "were", "used", "."], "h": {"id": "C0011524", "name": "C0011524#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [18, 19]}}
{"token": ["The", "burst", "reaction", "can", "be", "used", "for", "the", "easy", "and", "unambiguous", "determination", "of", "molar", "concentrations", "of", "C0011524#ent", "<e1>", "any", "preparation", ",", "which", "is", "free", "of", "non-specific", "C0011519#ent", "<e2>", "."], "h": {"id": "C0011524", "name": "C0011524#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [26, 27]}}
{"token": ["The", "binding", "of", "three", "loop", "diuretics", "piretanide", ",", "C0006376#ent", "<e1>", "and", "furosemide", ",", "to", "serum", "proteins", "patients", "with", "C0023890#ent", "<e2>", "fulminant", "hepatitis", "investigated", "using", "equilibrium", "dialysis"], "h": {"id": "C0006376", "name": "C0006376#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [18, 19]}}
{"token": ["The", "levels", "of", "the", "C0950150#ent", "<e1>", "CA", "and", "C1413043#ent", "<e2>", "in", "single", "erythrocytes", "of", "DBA/2J", "mice", "assayed", "by", "measuring", "the", "specific", "immunofluorescence", "of", "CA", "I", "C1413043#ent", "<e2>", "a", "microspectrofluorometric", "technique", "."], "h": {"id": "C0950150", "name": "C0950150#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "use", "chromatin", "immunoprecipitation", "detect", "transcription-dependent", "accumulation", "of", "the", "precursor", "mRNA", "pre-mRNA", ")", "splicing", "factors", "hnRNP", "A1", "C1427952#ent", "<e1>", "and", "U1", "and", "U5", "snRNPs", "the", "intron-containing", "human", "C0087140#ent", "<e2>", "gene", "."], "h": {"id": "C1427952", "name": "C1427952#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [28, 29]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "evaluate", "the", "prevalence", "of", "C0574960#ent", "<e1>", "in", "a", "group", "of", "patients", "with", "C0004943#ent", "<e2>", "BD", ")", "."], "h": {"id": "C0574960", "name": "C0574960#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [19, 20]}}
{"token": ["In", "this", "respect", ",", "the", "induced", "antibodies", "resembled", "the", "diverse", "C4284191#ent", "<e1>", "characteristics", "of", "naturally", "occurring", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e2>", ")", "anti-DNA", "autoantibodies"], "h": {"id": "C4284191", "name": "C4284191#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [19, 20]}}
{"token": ["There", "have", "been", "conflicting", "results", "as", "to", "which", "protein", "kinases-protein", "kinase", "A", "protein", "kinase", "B", "Akt", ")", ",", "other", "C0299851#ent", "<e1>", "or", "tyrosine", "kinases-are", "for", "shear-dependent", "C0669365#ent", "<e2>", "regulation", "."], "h": {"id": "C0299851", "name": "C0299851#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [26, 27]}}
{"token": ["Although", "transcription", "of", "the", "C1426344#ent", "<e1>", "also", "regulated", "by", "tunicamycin", ",", "etoposide", ",", "or", "C0075193#ent", "<e2>", ",", "FK506", "did", "not", "show", "any", "effects", "on", "these", "regulations", "."], "h": {"id": "C1426344", "name": "C1426344#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [14, 15]}}
{"token": ["Several", "clinical", "criteria", "the", "specific", "biochemical", "findings", "lead", "to", "the", "diagnosis", "of", "mixed", "connective", "tissue", "disease", "C0026272#ent", "<e1>", ")", "which", "is", "an", "C0004364#ent", "<e2>", "by", "cutaneous", "and", "visceral", "fibrosis", "widespread", "vascular", "pathology"], "h": {"id": "C0026272", "name": "C0026272#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [22, 23]}}
{"token": ["Arachnoid", "cyst", "near", "the", "quadrigeminal", "cistern", "been", "reported", "as", "C0078981#ent", "<e1>", "arachnoid", "cyst", "the", "quadrigeminal", "cistern", "paramesencephalic", "arachnoid", "cyst", "arachnoid", "cyst", "posterior", "to", "the", "third", "ventricle", "C0010709#ent", "<e2>", "of", "the", "cisterna", "ambiens"], "h": {"id": "C0078981", "name": "C0078981#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [26, 27]}}
{"token": ["An", "analysis", "of", "the", "efficacy", "of", "tacrolimus", "treatment", "in", "three", "patients", "with", "difficult", "and", "severe", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e1>", ")", "whose", "active", "disease", "been", "previously", "poorly", "controlled", "by", "C0010592#ent", "<e2>", "and", "cyclophosphamide", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [29, 30]}}
{"token": ["The", "unconjugated", "bile", "salts", "taurocholate", "and", "cholate", "were", "also", "effective", "C2985407#ent", "<e1>", "these", "conditions", ",", "with", "C0609830#ent", "<e2>", "of", "453+/-44", "and", "3760+/-710", "microM", "(", "at", "0", "mV", ")", "respectively", "."], "h": {"id": "C2985407", "name": "C2985407#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0609830", "name": "C0609830#ent", "pos": [16, 17]}}
{"token": ["This", "study", "examined", "the", "temporal", "effects", "of", "the", "polyamine", "synthesis", "inhibitor", "eflornithine", "(", "C0282042#ent", "<e1>", ")", "on", "vascular", "responses", "KCI", ",", "norepinephrine", ",", "C0037533#ent", "<e2>", "acetylcholine", "in", "aortic", "rings", "coarctation", "hypertensive", "rats", "."], "h": {"id": "C0282042", "name": "C0282042#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [23, 24]}}
{"token": ["These", "enzymes", "belong", "to", "the", "C3853653#ent", "<e1>", "which", "also", "includes", "poly(A)", "polymerases", "CCA-adding", "enzymes", "and", "other", "C0028632#ent", "<e2>", "."], "h": {"id": "C3853653", "name": "C3853653#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028632", "name": "C0028632#ent", "pos": [16, 17]}}
{"token": ["RT-PCR", "analysis", "decreased", "C1705977#ent", "<e1>", "but", "increased", "C1539478#ent", "<e2>", "in", "clozapine-treated", "PMN", "cells"], "h": {"id": "C1705977", "name": "C1705977#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [7, 8]}}
{"token": ["The", "C0014442#ent", "<e1>", "was", "able", "to", "remove", "gallic", "acid", "both", "C0072018#ent", "<e2>", "and", "hydrolysable", "tannins", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072018", "name": "C0072018#ent", "pos": [10, 11]}}
{"token": ["Drug-induced", "gingival", "hyperplasia", "usually", "associated", "with", "administration", "of", "C0020209#ent", "<e1>", "in", "individuals", "with", "C0014544#ent", "<e2>", "."], "h": {"id": "C0020209", "name": "C0020209#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [13, 14]}}
{"token": ["In", "comparison", ",", "C0699918#ent", "<e1>", "equally", "preferred", "IGFBP-3", "and", "C1334095#ent", "<e2>", ",", "followed", "by", "BP-1", ",", "BP-5", ",", "BP-6", ",", "and", "BP-2", "."], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334095", "name": "C1334095#ent", "pos": [9, 10]}}
{"token": ["C3640214#ent", "<e1>", "catalyzes", "guanine", "nucleotide", "exchange", "the", "small", "GTPases", "C0812234#ent", "<e2>", ",", "Rac1", ",", "and", "Cdc42", "."], "h": {"id": "C3640214", "name": "C3640214#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [9, 10]}}
{"token": ["To", "determine", "the", "extent", "of", "C0035585#ent", "<e1>", "prevalence", "of", "potential", "vector", "ticks", "the", "rural", "population", "C0016395#ent", "<e2>", ",", "Oman", "."], "h": {"id": "C0035585", "name": "C0035585#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016395", "name": "C0016395#ent", "pos": [15, 16]}}
{"token": ["We", "show", "that", "wild-type", "huntingtin", "coimmunoprecipitates", "with", "C1424690#ent", "<e1>", "and", "that", "less", "immunoprecipitated", "material", "is", "found", "in", "brain", "tissue", "C0020179#ent", "<e2>"], "h": {"id": "C1424690", "name": "C1424690#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020179", "name": "C0020179#ent", "pos": [19, 20]}}
{"token": ["Coadministration", "of", "MK-801", "(", "0.1", "mg/kg", ")", "with", "L-dopa", "(", "20", "mg/kg", ")", "induced", "marked", "C0013421#ent", "<e1>", "accompanied", "by", "bradykinesia", "and", "C0004134#ent", "<e2>", "."], "h": {"id": "C0013421", "name": "C0013421#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [21, 22]}}
{"token": ["In", "a", "group", "of", "30", "children", ",", "all", "of", "whom", "had", "severe", "C0024115#ent", "<e1>", "normal", "concentrations", "serum", "IgG", "IgA", "and", "C1706005#ent", "<e2>", ",", "airway-obstruction", "has", "been", "diagnosed", "in", "19", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [20, 21]}}
{"token": ["PDE4C-containing", "cosmids", "also", "contained", "the", "C0017337#ent", "<e1>", "for", "the", "C1425411#ent", "<e2>", "JUND", ",", "and", "the", "mini", "guanine", "nucleotide", "regulatory", "protein", "RAB3A", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425411", "name": "C1425411#ent", "pos": [9, 10]}}
{"token": ["With", "the", "core", "promoters", "analyzed", ",", "the", "former", "functions", "facilitating", "RNA", "polymerase", "II", "C0035678#ent", "<e1>", "recruitment", "to", "a", "preassembled", "TBP/TFIIB-containing", "scaffold", "and", "C1705526#ent", "<e2>", "strongly", "recruits", "TBP", "and", "TFIIB", "while", "C0035678#ent", "<e1>", "levels", "remain", "modest", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [13, 14]}}
{"token": ["This", "derivative", "corresponded", "to", "the", "modified", "C2917660#ent", "<e1>", "by", "allowing", "5-chloro-4-oxo[3,5", "-", "3H]pentanoic", "acid", "to", "react", "with", "C1418610#ent", "<e2>"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418610", "name": "C1418610#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "when", "survival", "assays", "performed", "under", "C2917660#ent", "<e1>", "starvation", "conditions", ",", "C1418610#ent", "<e2>", "did", "not", "confer", "protection", "against", "ciprofloxacin", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418610", "name": "C1418610#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "define", "a", "conserved", "HIF-VHL-prolyl", "hydroxylase", "pathway", "in", "C.", "elegans", "and", "use", "a", "genetic", "approach", "identify", "EGL-9", "as", "a", "C1564138#ent", "<e1>", "that", "regulates", "C3811709#ent", "<e2>", "by", "prolyl", "hydroxylation"], "h": {"id": "C1564138", "name": "C1564138#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3811709", "name": "C3811709#ent", "pos": [25, 26]}}
{"token": ["The", "kinetics", "of", "poly(ADP-ribose)", "synthesis", "by", "this", "C1335440#ent", "<e1>", ",", "and", "subsequent", "polymer", "degradation", "by", "C1418269#ent", "<e2>", "have", "been", "compared", "with", "the", "rate", "of", "DNA", "repair"], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418269", "name": "C1418269#ent", "pos": [15, 16]}}
{"token": ["C0085207#ent", "<e1>", "women", "who", "developed", "C0011849#ent", "<e2>", "had", "lower", "gestational", "insulin", "area-under-the-curve", "(", "P=0.05", ")", "."], "h": {"id": "C0085207", "name": "C0085207#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}}
{"token": ["The", "present", "work", "was", "undertaken", "to", "verify", "if", "acetamide", ",", "a", "MFA", "C3536843#ent", "<e1>", "and", "an", "C0000979#ent", "<e2>", "donor", ",", "protects", "rats", "against", "both", "Pm", "and", "MFA", "intoxications", "."], "h": {"id": "C3536843", "name": "C3536843#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [16, 17]}}
{"token": ["In", "the", "median", "eminence", ",", "but", "not", "the", "medial", "preoptic", "area", "parallel", "increases", "in", "the", "activity", "of", "tyrosine", "hydroxylase", "the", "turnover", "of", "dopamine", "(", "but", "not", "C3887648#ent", "<e1>", ")", "occurred", "following", "C0020514#ent", "<e2>", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [31, 32]}}
{"token": ["C0022265#ent", "<e1>", "of", "neuroblastoma", "(", "NB", ")", "cells", "implicates", "activation", "of", "C0813143#ent", "<e2>", "and", "TrkB", "RTKs", "as", "critical", "step", "to", "induce", "cell", "differentiation"], "h": {"id": "C0022265", "name": "C0022265#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0813143", "name": "C0813143#ent", "pos": [11, 12]}}
{"token": ["We", "studied", "the", "sensitivity", "of", "pulsatile", "and", "steady-state", "haemodynamic", "variables", "identifying", "vascular", "abnormalities", "assessing", "arterial", "responsiveness", "to", "C0017887#ent", "<e1>", "GTN", ")", "in", "patients", "with", "C0011849#ent", "<e2>", ",", "free", "from", "clinical", "complications", "the", "disease", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [24, 25]}}
{"token": ["Replacement", "of", "this", "loop", "with", "the", "homologous", "loop", "C1708015#ent", "<e1>", "dramatically", "reduced", "both", "the", "affinity", "of", "C1514773#ent", "<e2>", "for", "KGFR", "and", "its", "biological", "potency", "did", "not", "result", "in", "the", "ability", "to", "bind", "FGFR1", "."], "h": {"id": "C1708015", "name": "C1708015#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1514773", "name": "C1514773#ent", "pos": [16, 17]}}
{"token": ["We", "have", "collected", "electron", "paramagnetic", "resonance", "C1366515#ent", "<e1>", ")", "and", "electron", "nuclear", "double", "resonance", "ENDOR", ")", "spectra", "from", "the", "hydrogen", "peroxide", "of", "C0010760#ent", "<e2>", "termed", "ES", ",", "employing", "C1366515#ent", "<e1>", "microwave", "frequencies", "9.6", "and", "11.6", "GHz", "."], "h": {"id": "C0010760", "name": "C0010760#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1366515", "name": "C1366515#ent", "pos": [6, 7]}}
{"token": ["C0010760#ent", "<e1>", "with", "hydrogen", "peroxide", "generate", "two", "electron", "paramagnetic", "resonance", "C1366515#ent", "<e2>", ")", "free", "radical", "signals", "Fabian", ",", "M.", ",", "and", "Palmer", ",", "G.", "(", "1995", ")", "Biochemistry", "34", ",", "13802", "-", "13810", ")", "."], "h": {"id": "C0010760", "name": "C0010760#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366515", "name": "C1366515#ent", "pos": [10, 11]}}
{"token": ["C0003211#ent", "<e1>", "gene-1", "(", "NAG-1", ")", "is", "a", "C1333196#ent", "<e2>", "associated", "with", "pro-apoptotic", "and", "anti-tumorigenic", "properties", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [8, 9]}}
{"token": ["At", "least", "one", "visit", "to", "a", "physician", "at", "a", "primary", "health", "care", "centre", "been", "made", "for", "C0271429#ent", "<e1>", "65", "%", "of", "5", "year", "olds", "and", "for", "C0013595#ent", "<e2>", "8", "%", "."], "h": {"id": "C0271429", "name": "C0271429#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [26, 27]}}
{"token": ["To", "target", "Piga", "recombination", "the", "erythroid/megakaryocytic", "lineage", "in", "mice", ",", "the", "Cre/loxP", "system", "was", "used", ",", "and", "C1511573#ent", "<e1>", "was", "expressed", "under", "the", "transcriptional", "regulatory", "sequences", "C1333663#ent", "<e2>", "."], "h": {"id": "C1511573", "name": "C1511573#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1333663", "name": "C1333663#ent", "pos": [26, 27]}}
{"token": ["Although", "the", "effect", "of", "oral", "acyclovir", "to", "prevent", "recurrent", "C0019345#ent", "<e1>", "not", "confirmed", ",", "recurrent", "C0019348#ent", "<e2>", "lesions", "can", "be", "treated", "with", "ointment", "formulation", "successfully", "."], "h": {"id": "C0019345", "name": "C0019345#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0019348", "name": "C0019348#ent", "pos": [15, 16]}}
{"token": ["The", "kappaB", "motif-dependent", "production", "of", "Abeta42", "was", "suppressed", "by", "binding", "of", "NF-kappaB/p65", "to", "the", "PDZ", "domain", "the", "C3538960#ent", "<e1>", "X11L", ")", ",", "which", "a", "human", "homologue", "protein", "of", "C1412457#ent", "<e2>", "."], "h": {"id": "C3538960", "name": "C3538960#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412457", "name": "C1412457#ent", "pos": [28, 29]}}
{"token": ["The", "animal", "'s", "condition", "improved", "and", "fecal", "samples", "showed", "minimal", "numbers", "of", "C0085313#ent", "<e1>", "therapy", "with", "an", "C0003416#ent", "<e2>"], "h": {"id": "C0085313", "name": "C0085313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003416", "name": "C0003416#ent", "pos": [17, 18]}}
{"token": ["This", "article", "will", "focus", "on", "three", "specific", "topics", ":", "C0744066#ent", "<e1>", "psoriasis", ",", "and", "C0011630#ent", "<e2>"], "h": {"id": "C0744066", "name": "C0744066#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011630", "name": "C0011630#ent", "pos": [14, 15]}}
{"token": ["The", "astonishing", "recognition", "that", "self-propagating", "changes", "in", "C1510464#ent", "<e1>", "be", "at", "the", "basis", "of", "C0022336#ent", "<e2>", "changing", "our", "views", "of", "transmissible", "diseases"], "h": {"id": "C1510464", "name": "C1510464#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [14, 15]}}
{"token": ["The", "smallest", "C1421540#ent", "<e1>", "fragment", "that", "is", "toxic", "to", "E.", "coli", "of", "336", "C3539946#ent", "<e2>", "a", "calculated", "pI=9.99", "."], "h": {"id": "C1421540", "name": "C1421540#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [13, 14]}}
{"token": ["This", "C0017337#ent", "<e1>", ",", "termed", "phosphohippolin", "(", "C3494506#ent", "<e2>", ")", ",", "contains", "318", "bp", "open", "reading", "frame", "encoding", "a", "single", "transmembrane", "protein", "a", "5", "'", "signal", "peptide", "region"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3494506", "name": "C3494506#ent", "pos": [7, 8]}}
{"token": ["Silencing", "both", "acid", "and", "neutral", "ceramidases", "using", "small", "interfering", "RNA", "C1413858#ent", "<e1>", "mRNA", "expression", ",", "suggesting", "that", "C2674218#ent", "<e2>", "acts", "as", "an", "inhibitory", "ligand", "."], "h": {"id": "C1413858", "name": "C1413858#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2674218", "name": "C2674218#ent", "pos": [17, 18]}}
{"token": ["We", "found", "that", "a", "high-protein", "diet", "increased", "pancreatic", "weight", "protein", ",", "DNA", ",", "and", "C0008746#ent", "<e1>", "content", "similarly", "in", "CCK-deficient", "and", "C2987364#ent", "<e2>", "mice", "."], "h": {"id": "C0008746", "name": "C0008746#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [21, 22]}}
{"token": ["It", "is", "suggested", "that", "the", "relative", "activities", "of", "the", "C3540772#ent", "<e1>", "responsible", "for", "the", "conversion", "of", "prostaglandin", "endoperoxides", "C3540754#ent", "<e2>", ",", "thromboxane", "A2", "prostacyclin", "may", "be", "of", "great", "importance", "during", "parturition", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [18, 19]}}
{"token": ["The", "recent", "determination", "of", "the", "amino", "acid", "sequences", "C3540772#ent", "<e1>", "that", "metabolize", "C3540754#ent", "<e2>", "and", "steroids", "has", "revealed", "interesting", "connections", "between", "some", "of", "these", "C3540772#ent", "<e1>", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540754", "name": "C3540754#ent", "pos": [12, 13]}}
{"token": ["These", "results", "suggest", "that", "persistent", "accumulation", "of", "macrophages", "in", "mesangium", "induces", "C0178664#ent", "<e1>", "expression", "and", "activation", "of", "C0623362#ent", "<e2>", "."], "h": {"id": "C0178664", "name": "C0178664#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [17, 18]}}
{"token": ["However", ",", "a", "1,25-(OH)(2)D(3", ")", "suppression", "of", "several", "intra-/intercellular", "matrix", "modeling", "proteins", "such", "as", "sodium/potassium", "ATPase", "C1413473#ent", "<e1>", "aquaporin", "8", "cadherin", "17", "and", "RhoA", "suggests", "a", "C3537249#ent", "<e2>", "of", "tight", "junction", "permeability", "and", "paracellular", "calcium", "transport"], "h": {"id": "C1413473", "name": "C1413473#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3537249", "name": "C3537249#ent", "pos": [26, 27]}}
{"token": ["In", "murine", "macrophages", "stimulated", "either", "by", "A", "23187", "or", "C0175697#ent", "<e1>", "PGE2", "synthesis", "was", "inhibited", "by", "C2986618#ent", "<e2>", "1695", "even", "at", "low", "doses"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986618", "name": "C2986618#ent", "pos": [16, 17]}}
{"token": ["Macrophages", "from", "mice", "fed", "the", "OO", ",", "SO", ",", "or", "MO", "diets", "produced", "less", "tumor", "necrosis", "factor", "alpha", "response", "to", "C0175697#ent", "<e1>", "stimulation", "than", "those", "from", "mice", "fed", "the", "C2986618#ent", "<e2>", "or", "HCO", "diets", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2986618", "name": "C2986618#ent", "pos": [29, 30]}}
{"token": ["Subjects", "with", "C0426970#ent", "<e1>", "the", "pectoralis", "major", "to", "compress", "the", "upper", "rib", "cage", "increase", "intrathoracic", "pressure", "C3815497#ent", "<e2>", "."], "h": {"id": "C0426970", "name": "C0426970#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3815497", "name": "C3815497#ent", "pos": [16, 17]}}
{"token": ["The", "D2", "selective", "ligand", "C0536540#ent", "<e1>", "had", "no", "effect", "on", "the", "C0072892#ent", "<e2>", "response", "confirming", "that", "the", "D4", "receptor", "the", "major", "receptor", "subtype", "mediating", "dopamine", "induced", "suppression", "of", "adenylate", "cyclase", "the", "retina", "."], "h": {"id": "C0536540", "name": "C0536540#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072892", "name": "C0072892#ent", "pos": [11, 12]}}
{"token": ["C0009186#ent", "<e1>", "was", "suspected", "and", "empirically", "treated", "with", "C0016277#ent", "<e2>", "."], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [8, 9]}}
{"token": ["The", "KCC3", "and", "C1420095#ent", "<e1>", "cDNAs", "predict", "C0086376#ent", "<e2>", "of", "1083", "and", "1150", "amino", "acids", "respectively", "."], "h": {"id": "C1420095", "name": "C1420095#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}}
{"token": ["Patients", "with", "C0018801#ent", "<e1>", "acute", "myocardial", "infarction", "severe", "intraventricular", "conduction", "disturbances", "kaliemia", "less", "than", "3.8", "mEq/L", "or", "C0012265#ent", "<e2>", "greater", "than", "2", "ng/ml", "were", "not", "included", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0012265", "name": "C0012265#ent", "pos": [17, 18]}}
{"token": ["Using", "deletion", "mutants", "and", "the", "Sl17H", "C1706112#ent", "<e1>", ",", "we", "have", "investigated", "the", "role", "of", "the", "cytoplasmic", "domain", "sequences", "C1416656#ent", "<e2>", "in", "biosynthetic", "processing", "cell", "surface", "presentation", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416656", "name": "C1416656#ent", "pos": [19, 20]}}
{"token": ["Only", "the", "peptides", "from", "an", "N-terminal", "region", "(", "residues", "-1", "to", "37", ")", "were", "liberated", "by", "proteolytic", "treatment", "C0960371#ent", "<e1>", "or", "endoproteinase", "Lys-C", "resulting", "in", "a", "stable", "C2936230#ent", "<e2>"], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2936230", "name": "C2936230#ent", "pos": [27, 28]}}
{"token": ["Previously", ",", "we", "demonstrated", "that", "C1120859#ent", "<e1>", "activation", "by", "growth", "factors", "extracellular", "signal-regulated", "kinase", "C1705791#ent", "<e2>", ")", ";", "this", "enables", "tail", "deadhesion", "and", "allows", "productive", "motility", "."], "h": {"id": "C1120859", "name": "C1120859#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [14, 15]}}
{"token": ["The", "role", "of", "non-invasive", "positive", "pressure", "ventilation", "NIPPV", ")", "is", "well", "documented", "in", "patients", "with", "C0085581#ent", "<e1>", "kyphoscoliosis", ",", "tuberculosis", "sequelae", "or", "C0027868#ent", "<e2>"], "h": {"id": "C0085581", "name": "C0085581#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [22, 23]}}
{"token": ["C0154653#ent", "<e1>", "an", "uncommon", "manifestation", "of", "C0006840#ent", "<e2>", "."], "h": {"id": "C0154653", "name": "C0154653#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [6, 7]}}
{"token": ["Both", "forms", "have", "three", "C0207564#ent", "<e1>", "activities", ",", "which", "are", "classified", "as", "the", "C1416671#ent", "<e2>", ",", "chymotrypsin-like", ",", "and", "peptidylglutamylpeptide", "bond", "hydrolyzing", "activities", "."], "h": {"id": "C0207564", "name": "C0207564#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [13, 14]}}
{"token": ["Hexokinase", "inhibited", "the", "C0066239#ent", "<e1>", "by", "competing", "for", "endogenously", "synthesized", "C2744579#ent", "<e2>", "."], "h": {"id": "C0066239", "name": "C0066239#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [10, 11]}}
{"token": ["Thus", "fluvoxamine", ",", "but", "not", "citalopram", ",", "fluoxetine", ",", "C0070122#ent", "<e1>", "and", "sertraline", "is", "a", "potent", "inhbitor", "of", "C0207509#ent", "<e2>", "."], "h": {"id": "C0070122", "name": "C0070122#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0207509", "name": "C0207509#ent", "pos": [18, 19]}}
{"token": ["These", "results", "are", "consistent", "with", "earlier", "findings", "that", "C0057460#ent", "<e1>", "C0059945#ent", "<e2>", "cleave", "DNA", "5", "to", "an", "apurinic-apyrimidinic", "site", "that", "C0059945#ent", "<e2>", "more", "active", "."], "h": {"id": "C0057460", "name": "C0057460#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059945", "name": "C0059945#ent", "pos": [10, 11]}}
{"token": ["C0908034#ent", "<e1>", "and", "SSE2", "are", "thought", "to", "encode", "C1305923#ent", "<e2>", "of", "693", "aa", "with", "calculated", "M(r", ")", "'s", "of", "77,408", "and", "77,619", ",", "respectively", "."], "h": {"id": "C0908034", "name": "C0908034#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}}
{"token": ["The", "cytotoxic", "analogue", "somatostatin", "AN-238", "consisting", "of", "C0388166#ent", "<e1>", "(", "AN-201", ")", "linked", "to", "a", "somatostatin", "analogue", "C0072993#ent", "<e2>", "binds", "to", "receptors", "for", "somatostatin", "and", "is", "targeted", "to", "tumors", "expressing", "these", "receptors", "."], "h": {"id": "C0388166", "name": "C0388166#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072993", "name": "C0072993#ent", "pos": [17, 18]}}
{"token": ["The", "presence", "in", "C0289313#ent", "<e1>", "of", "a", "C3539768#ent", "<e2>", "PLA2", ")", "stimulated", "by", "light", "and", "guanosine", "5'-O-(3-thio)triphosphate", "first", "demonstrated", "in", "1987", "(", "Jelsema", ",", "C.", "L.(1987", ")", "J.", "Biol", "."], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539768", "name": "C3539768#ent", "pos": [7, 8]}}
{"token": ["For", "treatment", "complex", "therapy", "was", "used", ",", "including", "C3539185#ent", "<e1>", ",", "agents", "of", "desensitizing", "action", "antibiotics", ",", "C3540017#ent", "<e2>", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [17, 18]}}
{"token": ["Two", "structurally", "distinct", "types", "(", "A", ",", "B", ")", "of", "microscopic", "C0036231#ent", "<e1>", "were", "found", "in", "muscles", "of", "4", "of", "5", "C0615769#ent", "<e2>", "skunks", "."], "h": {"id": "C0036231", "name": "C0036231#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0615769", "name": "C0615769#ent", "pos": [21, 22]}}
{"token": ["In", "this", "large", "C0242339#ent", "<e1>", "population", ",", "elevated", "C1826658#ent", "<e2>", "is", "an", "independent", "predictor", "of", "advanced", "carotid", "plaques", "in", "male", "subjects", "."], "h": {"id": "C0242339", "name": "C0242339#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1826658", "name": "C1826658#ent", "pos": [8, 9]}}
{"token": ["The", "C1419050#ent", "<e1>", "was", "used", "as", "an", "immobilization", "matrix", "C1706005#ent", "<e2>", "the", "ECL", "reagent", "+", ")", "due", "to", "the", "electrostatic", "interactions", "between", "sulfonic", "acid", "groups", "and", "Ru(bpy)3(2", "+", ")", "cations", "."], "h": {"id": "C1419050", "name": "C1419050#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [9, 10]}}
{"token": ["Because", "of", "these", "results", "and", "that", "no", "mutations", "were", "detected", "on", "the", "two", "C0017337#ent", "<e1>", "in", "a", "previous", "study", ",", "we", "think", "that", "C2347263#ent", "<e2>", "and", "Leu2", "can", "be", "excluded", "as", "tumor", "suppressor", "genes"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2347263", "name": "C2347263#ent", "pos": [23, 24]}}
{"token": ["C0085655#ent", "<e1>", "(", "PM", ")", "and", "dermatomyositis", "(", "DM", ")", "are", "C0027121#ent", "<e2>", "dysimmune", "origin", "."], "h": {"id": "C0085655", "name": "C0085655#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0027121", "name": "C0027121#ent", "pos": [11, 12]}}
{"token": ["Another", "trial", ",", "the", "Diabetes", "Atherosclerosis", "Intervention", "Study", "(", "DAIS", ")", "has", "also", "provided", "angiographic", "evidence", "to", "show", "that", "C0033228#ent", "<e1>", "treatment", "may", "C1956346#ent", "<e2>", "progression", "in", "type", "2", "diabetes"], "h": {"id": "C0033228", "name": "C0033228#ent", "pos": [19, 20]}, "relation": "may_prevent", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [23, 24]}}
{"token": ["Significant", "CTL", "activity", "and", "LAK", "activity", "against", "C1705846#ent", "<e1>", "developed", "from", "RLMNCs", "after", "stimulation", "with", "OK-432", "or", "C0879590#ent", "<e2>", "."], "h": {"id": "C1705846", "name": "C1705846#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [17, 18]}}
{"token": ["Immature", "B", "lineage", "acute", "lymphoblastic", "leukemia", "C1704799#ent", "<e1>", ")", "is", "divided", "into", "two", "subtypes", ",", "'", "pre-B", "'", "and", "'", "early", "pre-B", "'", "C1704799#ent", "<e1>", ",", "by", "the", "presence", "or", "absence", "of", "cytoplasmic", "immunoglobulin", "C1706331#ent", "<e1>", ")", "."], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [34, 35]}}
{"token": ["We", "conclude", "that", "C1538503#ent", "<e1>", "can", "not", "be", "required", "for", "incorporation", "of", "C1418753#ent", "<e2>", "or", "NUP107", "or", "be", "required", "for", "maintaining", "NPC", "stability", "."], "h": {"id": "C1538503", "name": "C1538503#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418753", "name": "C1418753#ent", "pos": [12, 13]}}
{"token": ["Eight", "weeks", "after", "the", "induction", "of", "C0011849#ent", "<e1>", "MDA", ",", "levels", "were", "increased", ",", "and", "NR2A", "and", "C3538769#ent", "<e2>", "concentrations", "were", "reduced", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3538769", "name": "C3538769#ent", "pos": [17, 18]}}
{"token": ["Co-incubation", "with", "the", "MEK", "inhibitors", "U0126", "(", "500", "nM", ")", "or", "PD", "98059", "(", "10", "microM", ")", "blocked", "the", "increased", "C0812281#ent", "<e1>", "production", "seen", "with", "all", "three", "C2987634#ent", "<e2>", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [27, 28]}}
{"token": ["For", "instance", ",", "C0812281#ent", "<e1>", ",", "Cig", ",", "and", "PGJ2", "were", "all", "potent", "C2987634#ent", "<e2>", "of", "PPARgamma", "transactivation", "lung", "adenocarcinoma", "cell", "lines", "these", "same", "ligands", "had", "no", "effect", "squamous", "cell", "large", "cell", "carcinomas", "the", "lung", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}}
{"token": ["Autosomal", "dominant", "iron", "storage", "disease", "a", "consequence", "of", "C1456396#ent", "<e1>", "mutations", ",", "and", "a", "polymorphism", "in", "the", "C1853733#ent", "<e2>", "to", "be", "involved", "in", "the", "African", "iron", "overload", "syndrome"], "h": {"id": "C1456396", "name": "C1456396#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1853733", "name": "C1853733#ent", "pos": [17, 18]}}
{"token": ["We", "discovered", "that", "C1427378#ent", "<e1>", "binds", "the", "anaphase-promoting", "complex/cyclosome", "APC/C", ")", ",", "an", "C1418270#ent", "<e2>", "controls", "the", "cell", "cycle"], "h": {"id": "C1427378", "name": "C1427378#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [13, 14]}}
{"token": ["The", "purified", "C1538187#ent", "<e1>", "markedly", "stimulated", "the", "import", "of", "purified", "or", "in", "vitro", "synthesized", "C0268542#ent", "<e2>", "into", "the", "mitochondria", "."], "h": {"id": "C1538187", "name": "C1538187#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268542", "name": "C0268542#ent", "pos": [14, 15]}}
{"token": ["The", "most", "frequent", "first", "symptoms", "of", "C1417325#ent", "<e1>", "the", "following", ":", "sensory", "symptoms", "optic", "neuritis", "motor", "and", "C0393534#ent", "<e2>"], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0393534", "name": "C0393534#ent", "pos": [17, 18]}}
{"token": ["There", "is", "an", "association", "between", "C0085580#ent", "<e1>", "the", "use", "of", "C0003392#ent", "<e2>", "particularly", "thioguanine", "."], "h": {"id": "C0085580", "name": "C0085580#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [10, 11]}}
{"token": ["Lethargy", ",", "anorexia", "and", "vomiting", "suggest", "C0554309#ent", "<e1>", "in", "cats", "with", "C4043426#ent", "<e2>", "."], "h": {"id": "C0554309", "name": "C0554309#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4043426", "name": "C4043426#ent", "pos": [11, 12]}}
{"token": ["The", "activities", "of", "sialyl-", ",", "fucosyl-", "and", "C0016964#ent", "<e1>", "were", "measured", "in", "membrane", "preparations", "from", "bovine", "C0235267#ent", "<e2>", "."], "h": {"id": "C0016964", "name": "C0016964#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [16, 17]}}
{"token": ["IL-6", "also", "induced", "phosphorylation", "of", "downstream", "targets", "of", "C0812228#ent", "<e1>", ",", "including", "Bad", ",", "C4283740#ent", "<e2>", ",", "and", "FKHR", ",", "confirming", "C0812228#ent", "<e1>", "activation", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [14, 15]}}
{"token": ["STAT3", ",", "DNMT1", ",", "and", "C1334032#ent", "<e1>", "complexes", "and", "bind", "to", "the", "C1705637#ent", "<e2>", "promoter", "in", "vivo"], "h": {"id": "C1334032", "name": "C1334032#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705637", "name": "C1705637#ent", "pos": [12, 13]}}
{"token": ["Side", "effects", "including", "C0004134#ent", "<e1>", ",", "may", "result", "from", "C0010977#ent", "<e2>", "administration", "."], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010977", "name": "C0010977#ent", "pos": [9, 10]}}
{"token": ["The", "three", "base", "ingredients", "similar", "responses", ",", "although", "steers", "fed", "BEET", "had", "slightly", "greater", "OM", "and", "C1367656#ent", "<e1>", "digestibilities", "than", "those", "fed", "CANE", "or", "C1413753#ent", "<e2>", "."], "h": {"id": "C1367656", "name": "C1367656#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413753", "name": "C1413753#ent", "pos": [24, 25]}}
{"token": ["Constitutively", "active", "RhoA", "activated", "the", "Rho", "kinase", "its", "downstream", "effectors", ",", "whereas", "constitutively", "active", "C1419227#ent", "<e1>", "and", "Cdc42", "activated", "the", "C1337052#ent", "<e2>", "epithelial", "cells"], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337052", "name": "C1337052#ent", "pos": [20, 21]}}
{"token": ["C0282051#ent", "<e1>", "used", "for", "the", "treatment", "of", "C0027404#ent", "<e2>", "in", "adults", "and", "behavioral", "syndromes", "children", "."], "h": {"id": "C0282051", "name": "C0282051#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0027404", "name": "C0027404#ent", "pos": [7, 8]}}
{"token": ["It", "is", "concluded", "that", "the", "incidence", "of", "delayed", "C0018799#ent", "<e1>", "radiotherapy", "is", "relatively", "high", ";", "C0265122#ent", "<e2>", "coronary", "artery", "disease", "the", "most", "frequent", "manifestations", "of", "this", "disease", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0265122", "name": "C0265122#ent", "pos": [15, 16]}}
{"token": ["However", ",", "the", "C1333200#ent", "<e1>", "level", "of", "C3815884#ent", "<e2>", "different", "pattern", "of", "changes", ",", "which", "also", "compared", "with", "the", "parental", "strain", "XP55", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3815884", "name": "C3815884#ent", "pos": [7, 8]}}
{"token": ["The", "use", "of", "drugs", "that", "disrupt", "C1333200#ent", "<e1>", "that", "inhibit", "C3815884#ent", "<e2>", "that", "inhibition", "of", "capping", "prevents", "uroid", "formation", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3815884", "name": "C3815884#ent", "pos": [10, 11]}}
{"token": ["We", "have", "previously", "reported", "that", "C0078956#ent", "<e1>", "causes", "repression", "of", "C1412330#ent", "<e2>", "but", "the", "signaling", "pathways", "this", "effect", "remain", "elusive", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412330", "name": "C1412330#ent", "pos": [10, 11]}}
{"token": ["To", "assess", "the", "efficacy", "and", "safety", "of", "oral", "beclomethasone", "dipropionate", "C1422585#ent", "<e1>", ")", "coated", "tablets", "in", "adults", "with", "mild-to-moderate", "C0010346#ent", "<e2>"], "h": {"id": "C1422585", "name": "C1422585#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [19, 20]}}
{"token": ["In", "the", "double-blind", "randomised", "part", "the", "study", "2-week", "courses", "of", "C1422585#ent", "<e1>", "or", "betamethasone", "enemas", "assessed", "in", "9", "patients", "having", "exacerbations", "of", "C0010346#ent", "<e2>"], "h": {"id": "C1422585", "name": "C1422585#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [22, 23]}}
{"token": ["This", "study", "examines", "the", "efficacy", "and", "safety", "of", "C0022616#ent", "<e1>", "in", "the", "control", "of", "severe", "primary", "and", "C0155620#ent", "<e2>", "including", "renal", "hypertension"], "h": {"id": "C0022616", "name": "C0022616#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0155620", "name": "C0155620#ent", "pos": [17, 18]}}
{"token": ["However", "loss", "of", "the", "ASE", "disrupts", "Lefty2", "(", "C1705892#ent", "<e1>", ")", "expression", "and", "causes", "delayed", "C2698694#ent", "<e2>", "expression", "leading", "to", "late", "onset", "relatively", "minor", "LR", "patterning", "defects", "."], "h": {"id": "C1705892", "name": "C1705892#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2698694", "name": "C2698694#ent", "pos": [15, 16]}}
{"token": ["The", "cyclic", "AMP-enhancing", "agent", "C0917964#ent", "<e1>", "affected", "the", "production", "of", "C0623362#ent", "<e2>", "in", "a", "cell-type-specific", "way", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [10, 11]}}
{"token": ["A", "56-year-old", "woman", "with", "a", "history", "of", "C3815497#ent", "<e1>", "after", "drinking", "fluids", "diagnosed", "as", "C0267094#ent", "<e2>", "upper", "gastrointestinal", "series", "showed", "a", "diverticulum", "in", "the", "middle", "portion", "the", "esophagus", "with", "a", "fistula", "between", "the", "esophagus", "and", "right", "lower", "lung"], "h": {"id": "C3815497", "name": "C3815497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0267094", "name": "C0267094#ent", "pos": [14, 15]}}
{"token": ["Study", "of", "the", "antiparasitic", "properties", "of", "obtained", "C2936588#ent", "<e1>", "well", "as", "of", "four", "related", "C0005034#ent", "<e2>", "previously", "described", ",", "was", "carried", "out", "using", "cytotoxicity", "assays", "Trichomonas", "vaginalis", "epimastigote", "form", "of", "Trypanosoma", "cruzi", "protozoa", "."], "h": {"id": "C2936588", "name": "C2936588#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005034", "name": "C0005034#ent", "pos": [14, 15]}}
{"token": ["C0010648#ent", "<e1>", "and", "cysteine", "esters", "found", "to", "be", "peroxidase-oxidase", "substrates", "eosinophil", "peroxidase", "C1417245#ent", "<e2>", ",", "whereas", "other", "thiols", "tested", "were", "inactive", "or", "poorly", "active", "with", "these", "peroxidases", "."], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417245", "name": "C1417245#ent", "pos": [12, 13]}}
{"token": ["Presenting", "features", "were", "macrocrania", "in", "four", "cases", ",", "haemorrhage", "or", "C0018681#ent", "<e1>", "in", "three", "and", "nonhaemorrhagic", "neurological", "deficits", "or", "and", "C0684338#ent", "<e2>", "two", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0684338", "name": "C0684338#ent", "pos": [20, 21]}}
{"token": ["Studies", "of", "sera", "from", "children", "with", "C0003864#ent", "<e1>", "this", "information", ";", "corresponding", "C1705295#ent", "<e2>", "data", "are", "relatively", "lacking", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705295", "name": "C1705295#ent", "pos": [12, 13]}}
{"token": ["Sequence", "analyses", "that", "rat", "intestine", "contained", "not", "only", "the", "previously", "reported", "L-form", "and", "S-form", "C-CAMs", "(", "renamed", "C-CAM1", "and", "C0966269#ent", "<e1>", "respectively", ")", "but", "also", "a", "new", "C0597298#ent", "<e2>", ",", "C-CAM3", "."], "h": {"id": "C0966269", "name": "C0966269#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [27, 28]}}
{"token": ["The", "localisation", "of", "C3272754#ent", "<e1>", "to", "newly", "formed", "focal", "adhesions", "that", "C1420479#ent", "<e2>", "phosphorylation", "may", "also", "be", "important", "in", "this", "regard", "."], "h": {"id": "C3272754", "name": "C3272754#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420479", "name": "C1420479#ent", "pos": [11, 12]}}
{"token": ["C0059438#ent", "<e1>", "treatment", "also", "led", "to", "an", "induction", "of", "C3540625#ent", "<e2>", "but", "no", "change", "in", "Kip1/27", ",", "CDK2", ",", "and", "cyclin", "D1", "a", "decrease", "in", "CDK4", "only", "at", "low", "doses"], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540625", "name": "C3540625#ent", "pos": [9, 10]}}
{"token": ["This", "cluster", "includes", "genes", "annotated", "as", "a", "phosphotransferase", "system", "II", "celA", ",", "celB", ",", "and", "celC", ")", ",", "a", "glucokinase", "(", "C1366441#ent", "<e1>", ")", ",", "and", "a", "C0017764#ent", "<e2>", "(", "celG", ")", "."], "h": {"id": "C1366441", "name": "C1366441#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0017764", "name": "C0017764#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", ",", "cells", "from", "five", "patients", "with", "Ia", "+", "CALLA-B1-c", "mu-", "non-T", "cell", "C0812385#ent", "<e1>", "could", "not", "be", "induced", "with", "C0256103#ent", "<e2>", "to", "express", "CALLA", ",", "B1", "or", "c", "mu", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [21, 22]}}
{"token": ["We", "recommend", "following", "the", "administration", "guidelines", "C0073631#ent", "<e1>", "for", "renal-compromised", "patients", "in", "those", "with", "C0030193#ent", "<e2>", "episodes", "of", "sickle", "cell", "disease", "and", "if", "used", "in", "this", "patient", "population", "renal", "function", "be", "very", "closely", "monitored", "."], "h": {"id": "C0073631", "name": "C0073631#ent", "pos": [6, 7]}, "relation": "may_prevent", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [14, 15]}}
{"token": ["C0031507#ent", "<e1>", "nonresponders", "were", "proposed", "as", "a", "model", "for", "C0014556#ent", "<e2>"], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0014556", "name": "C0014556#ent", "pos": [9, 10]}}
{"token": ["We", "studied", "the", "downstream", "consequences", "of", "p38-MAPK", "activation", "by", "examining", "activation", "of", "C1452441#ent", "<e1>", "C1442514#ent", "<e2>", ")", "and", "phosphorylation", "of", "the", "C1442514#ent", "<e2>", "substrate", ",", "the", "small", "heat", "shock", "protein", "."], "h": {"id": "C1452441", "name": "C1452441#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1442514", "name": "C1442514#ent", "pos": [14, 15]}}
{"token": ["In", "clinical", "trials", "the", "efficacy", "and", "cost", "effectiveness", "of", "recommended", "oral", "and", "intravenous", "antibiotic", "therapies", "have", "been", "compared", "in", "early", "C0024198#ent", "<e1>", "arthritis", "and", "C3899282#ent", "<e2>"], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [20, 21]}, "relation": "nichd_parent_of", "t": {"id": "C3899282", "name": "C3899282#ent", "pos": [24, 25]}}
{"token": ["We", "studied", "4", "children", "with", "type", "II", "C0033788#ent", "<e1>", "3", "of", "whom", "had", "unequivocal", "evidence", "of", "C0003504#ent", "<e2>", "by", "phonocardiography", "and", "M-mode", "echocardiography"], "h": {"id": "C0033788", "name": "C0033788#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [16, 17]}}
{"token": ["The", "radiological", "and", "clinical", "features", "of", "41", "cases", "of", "acute", "gastric", "anisakiasis", ",", "a", "form", "of", "C0023049#ent", "<e1>", "by", "eating", "poorly", "cooked", "fish", "C0162576#ent", "<e2>", "are", "reviewed", "."], "h": {"id": "C0023049", "name": "C0023049#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0162576", "name": "C0162576#ent", "pos": [23, 24]}}
{"token": ["We", "recently", "found", "that", "CRF", "acts", "as", "a", "C3537041#ent", "<e1>", "the", "X.", "laevis", "tail", ",", "and", "that", "the", "C1413708#ent", "<e2>", "can", "block", "CRF", "action", "and", "hasten", "tail", "muscle", "cell", "death", "."], "h": {"id": "C3537041", "name": "C3537041#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413708", "name": "C1413708#ent", "pos": [18, 19]}}
{"token": ["The", "degree", "of", "the", "inhibition", "of", "the", "C0752312#ent", "<e1>", "activation", "by", "pepstatin", "A", "captopril", "and", "the", "C0815017#ent", "<e2>", "losartan", "was", "almost", "the", "same", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0815017", "name": "C0815017#ent", "pos": [16, 17]}}
{"token": ["Compared", "to", "the", "control", "group", "C0014544#ent", "<e1>", "patients", "on", "C3537002#ent", "<e2>", "higher", "blood", "levels", "homocysteine", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C3537002", "name": "C3537002#ent", "pos": [9, 10]}}
{"token": ["Identification", "of", "SEPTIN6", "and", "the", "C1539748#ent", "<e1>", "family", "members", "hCDCrel", "and", "MSF", "as", "partner", "genes", "of", "C0919528#ent", "<e2>", "suggests", "a", "common", "pathway", "to", "leukaemogenesis", "."], "h": {"id": "C1539748", "name": "C1539748#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919528", "name": "C0919528#ent", "pos": [16, 17]}}
{"token": ["Microcystins", "(", "C1822783#ent", "<e1>", ")", "are", "hepatotoxins", "with", "potent", "inhibitor", "activity", "of", "protein", "phosphatases", "C1826646#ent", "<e2>", "and", "PP2A", "."], "h": {"id": "C1822783", "name": "C1822783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826646", "name": "C1826646#ent", "pos": [14, 15]}}
{"token": ["A", "new", "glycosylated", "furanocoumarin", ",", "alpha-L-rhamnopyranosyl-(1", "-", "->6)-beta-D-glucopyranosyl-bergaptol", "(", "1", ")", ",", "has", "been", "isolated", "from", "Dorstenia", "contrajerva", "with", "three", "known", "C1136319#ent", "<e1>", ",", "catechin", "and", "C0014485#ent", "<e2>", "."], "h": {"id": "C1136319", "name": "C1136319#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0014485", "name": "C0014485#ent", "pos": [26, 27]}}
{"token": ["The", "C3659502#ent", "<e1>", "ADH", ")", "activity", "of", "human", "C0054318#ent", "<e2>", "SCHAD", ")", "has", "been", "characterized", "kinetically", "."], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054318", "name": "C0054318#ent", "pos": [8, 9]}}
{"token": ["Neutral", "endopeptidase", "24.11", "C1723257#ent", "<e1>", "inactivates", "atrial", "natriuretic", "peptide", "cleaving", "the", "hormone", "between", "C0660378#ent", "<e2>", "and", "Phe8", ",", "and", "inhibitors", "of", "the", "enzyme", "have", "consequent", "natriuretic", "and", "diuretic", "properties", "."], "h": {"id": "C1723257", "name": "C1723257#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0660378", "name": "C0660378#ent", "pos": [13, 14]}}
{"token": ["To", "assess", "the", "efficacy", "and", "maximum", "dose-intensity", "of", "a", "new", "C1458146#ent", "<e1>", "topo", "I)-targeting", "agent", ",", "9-aminocamptothecin", "(", "C0214192#ent", "<e2>", ")", ",", "in", "patients", "with", "relapsed", "or", "refractory", "lymphomas"], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [10, 11]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0214192", "name": "C0214192#ent", "pos": [18, 19]}}
{"token": ["The", "present", "findings", "with", "fluoxetine", "are", "consistent", "with", "virtual", "absence", "of", "C3537004#ent", "<e1>", "or", "other", "side", "effects", "observed", "with", "C0003289#ent", "<e2>", "animal", "models", "during", "the", "treatment", "of", "depressed", "patients", "."], "h": {"id": "C3537004", "name": "C3537004#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [19, 20]}}
{"token": ["Fluoxetine", "does", "not", "have", "the", "C3537004#ent", "<e1>", ",", "hypotensive", ",", "and", "sedative", "effects", "C0003289#ent", "<e2>", "has", "no", "particular", "cardiovascular", "effects", "overdoses", "do", "not", "cause", "serious", "toxic", "effects"], "h": {"id": "C3537004", "name": "C3537004#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [13, 14]}}
{"token": ["Abatacept", "is", "the", "first", "C1254351#ent", "<e1>", "in", "a", "new", "class", "of", "disease-modifying", "antirheumatic", "drugs", "C0242708#ent", "<e2>", ")", "known", "as", "selective", "costimulation", "modulators", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0242708", "name": "C0242708#ent", "pos": [14, 15]}}
{"token": ["Effects", "of", "thyroliberin", "(", "TRH", ")", "and", "C0000477#ent", "<e1>", "(", "4AP", ")", "were", "studied", "on", "prolactin", "(", "C1418938#ent", "<e2>", ")", "secreting", "rat", "pituitary", "tumour", "cells", "culture", "(", "GH3", "cells", ")", "."], "h": {"id": "C0000477", "name": "C0000477#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [17, 18]}}
{"token": ["Previous", "investigators", "have", "suggested", "that", "proteolysis", "by", "calpain", ",", "a", "Ca2", "+", "-dependent", "C1947941#ent", "<e1>", ",", "causes", "muscle", "fiber", "degradation", "in", "Duchenne", "and", "C0026850#ent", "<e2>", "DMD/BMD", ")", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026850", "name": "C0026850#ent", "pos": [23, 24]}}
{"token": ["It", "has", "been", "shown", "by", "several", "investigators", "that", "some", "endopeptidases", "such", "as", "Ca2", "+", "-activated", "C1947941#ent", "<e1>", "some", "other", "serine", "proteases", "play", "important", "roles", "in", "C0026850#ent", "<e2>"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0026850", "name": "C0026850#ent", "pos": [25, 26]}}
{"token": ["An", "etiological", "link", "between", "CD34", "expression", "in", "common", "C1704799#ent", "<e1>", "patients", "and", "C0012739#ent", "<e2>", "was", "suggested", "."], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [12, 13]}}
{"token": ["The", "t-PA", "stimulator", "activity", "high", "in", "both", "acute", "myeloblastic", "leukaemia", "AML", ")", "and", "acute", "lymphoblastic", "leukaemia", "C1704799#ent", "<e1>", ")", ",", "especially", "in", "C0012739#ent", "<e2>", ",", "but", "this", "activity", "was", "not", "detected", "in", "chronic", "myelocytic", "leukaemia", "CML", ")", "or", "normal", "cells"], "h": {"id": "C1704799", "name": "C1704799#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [22, 23]}}
{"token": ["Rupture", "often", "calls", "for", "aggressive", "surgical", "treatment", "it", "may", "be", "complicated", "immediately", "by", "anaphylaxis", ",", "earlier", "by", "C0014009#ent", "<e1>", "or", "lung", "abscess", "and", "later", "by", "secondary", "disseminated", "C0013502#ent", "<e2>", "."], "h": {"id": "C0014009", "name": "C0014009#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0013502", "name": "C0013502#ent", "pos": [27, 28]}}
{"token": ["Similarly", ",", "prelabeling", "with", "H2-DIDS", "reduced", "subsequent", "labeling", "of", "band", "3", "C1705281#ent", "<e1>", "by", "over", "90", "%", ",", "and", "C0053752#ent", "<e2>", "prelabeling", "reduced", "C1705281#ent", "<e1>", "labeling", "by", "approximately", "95", "%", "."], "h": {"id": "C0053752", "name": "C0053752#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [11, 12]}}
{"token": ["It", "has", "been", "shown", "that", "expression", "of", "matrix", "metalloproteinases", "C3494976#ent", "<e1>", ")", "is", "induced", "by", "C4285344#ent", "<e2>", "during", "Xenopus", "metamorphosis"], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4285344", "name": "C4285344#ent", "pos": [15, 16]}}
{"token": ["C1417679#ent", "<e1>", "peripherally", "associated", "with", "steroid", "hormones", "also", "affected", ":", "C1412336#ent", "<e2>", ",", "GSTtheta2", ",", "and", "Id2", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412336", "name": "C1412336#ent", "pos": [10, 11]}}
{"token": ["Thymoxamine", "was", "useful", "in", "individuals", "with", "C1410927#ent", "<e1>", "were", "at", "risk", "of", "acute", "closed-angle", "glaucoma", "dilation", "with", "an", "C0001637#ent", "<e2>"], "h": {"id": "C1410927", "name": "C1410927#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001637", "name": "C0001637#ent", "pos": [18, 19]}}
{"token": ["Phosphorylation", "of", "C3539639#ent", "<e1>", "and", "C1414351#ent", "<e2>", "and", "the", "association", "of", "C1414351#ent", "<e2>", "with", "4E-BP1", "were", "also", "greater", "than", "control", "values", "after", "ischemia", "but", "only", "in", "hearts", "perfused", "with", "glucose", "plus", "palmitate", "."], "h": {"id": "C3539639", "name": "C3539639#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414351", "name": "C1414351#ent", "pos": [5, 6]}}
{"token": ["Progressive", "C0011989#ent", "<e1>", "characterized", "clinically", "by", "crippling", "leg", "pain", "fatigue", ",", "C0018681#ent", "<e2>", ",", "poor", "appetite", "muscle", "weakness", "and", "waddling", "gait"], "h": {"id": "C0011989", "name": "C0011989#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [11, 12]}}
{"token": ["This", "data", "supports", "the", "role", "of", "C3714873#ent", "<e1>", "ERK", "activation", "in", "human", "C0004153#ent", "<e2>", "which", "identifies", "C3714873#ent", "<e1>", "new", "therapeutical", "targets", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714873", "name": "C3714873#ent", "pos": [6, 7]}}
{"token": ["C1142985#ent", "<e1>", "is", "indicated", "in", "the", "management", "of", "hyperlipidemia", ",", "C0020445#ent", "<e2>", "and", "sitosterolemia", "and", "significantly", "increases", "the", "percentage", "of", "patients", "able", "to", "reach", "their", "lipid-lowering", "goals", "."], "h": {"id": "C1142985", "name": "C1142985#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [10, 11]}}
{"token": ["The", "primary", "structure", "the", "hydropathic", "character", "of", "the", "C0070929#ent", "<e1>", "from", "Methanosarcina", "barkeri", "compared", "with", "those", "of", "the", "C3541394#ent", "<e2>", "from", "Methanobacterium", "thermoautotrophicum", "Methanothermus", "fervidus", "and", "Methanopyrus", "kandleri"], "h": {"id": "C0070929", "name": "C0070929#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}}
{"token": ["We", "present", "a", "case", "of", "lateral", "and", "sagittal", "sinus", "thrombosis", "by", "C0007785#ent", "<e1>", "a", "girl", "with", "C0033626#ent", "<e2>", "masked", "mastoiditis", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033626", "name": "C0033626#ent", "pos": [16, 17]}}
{"token": ["Mild", "overlap", "of", "clinical", "features", "with", "Charcot-Marie-Tooth", "(", "CMT", ")", "disease", "type", "1", "C0270911#ent", "<e1>", ")", "may", "lead", "patients", "with", "C2698698#ent", "<e2>", "to", "be", "misdiagnosed", "as", "having", "C0270911#ent", "<e1>", "."], "h": {"id": "C0270911", "name": "C0270911#ent", "pos": [13, 14]}, "relation": "disease_has_associated_gene", "t": {"id": "C2698698", "name": "C2698698#ent", "pos": [20, 21]}}
{"token": ["Clinical", "applications", "C0917964#ent", "<e1>", "as", "a", "hypotensive", ",", "C0037766#ent", "<e2>", ",", "lipolytic", ",", "or", "antithrombotic", "agents", "for", "the", "treatment", "of", "glaucoma", "or", "cardiac", "insufficiency", "other", "challenges", "for", "the", "future", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0037766", "name": "C0037766#ent", "pos": [8, 9]}}
{"token": ["The", "C0243046#ent", "<e1>", "activated", "by", "N-methyl-D-aspartate", "(N-Me-D-Asp)", "also", "known", "as", "C0022614#ent", "<e2>", ")", "are", "a", "major", "determinant", "of", "central", "nervous", "system", "neuronal", "excitability", "."], "h": {"id": "C0243046", "name": "C0243046#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [10, 11]}}
{"token": ["Both", "ARC-111", "and", "C0246415#ent", "<e1>", "had", "a", "C1412058#ent", "<e2>", "of", "21", "days", "in", "NCI-H460", "xenografts", ",", "and", "both", "ARC-111", "and", "gemcitabine", "had", "a", "C1412058#ent", "<e2>", "of", "7", "days", "in", "MiaPaCa2", "xenograft", "."], "h": {"id": "C0246415", "name": "C0246415#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412058", "name": "C1412058#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "C0246415#ent", "<e1>", "is", "also", "a", "substrate", "for", "the", "C1412058#ent", "<e2>", "transporter", "protein", "ABCB1", "."], "h": {"id": "C0246415", "name": "C0246415#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412058", "name": "C1412058#ent", "pos": [10, 11]}}
{"token": ["In", "the", "C0011876#ent", "<e1>", "group", ",", "the", "aqueous", "humor", "C0003402#ent", "<e2>", "correlated", "positively", "with", "the", "aqueous", "humor", "uric", "acid", "levels", "(", "p", "<", "0.05", ")", "."], "h": {"id": "C0011876", "name": "C0011876#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [9, 10]}}
{"token": ["The", "neurological", "features", "transient", "ischaemic", "attacks", "secondary", "to", "atherosclerosis", "in", "the", "common", "carotid", "arteries", "one", "patient", ")", ",", "C4021582#ent", "<e1>", "one", "patient", ")", "and", "peripheral", "neuropathy", "a", "possible", "C0005956#ent", "<e2>", "(", "one", "patient", ")", "."], "h": {"id": "C4021582", "name": "C4021582#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0005956", "name": "C0005956#ent", "pos": [28, 29]}}
{"token": ["Systemic", "triazoles", "inhibitors", "of", "cytochrome", "P450", "CYP", ")", "C0026794#ent", "<e1>", ",", "such", "as", "CYP3A4", ",", "CYP2C9", "and", "C3714749#ent", "<e2>", ",", "to", "varying", "degrees", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714749", "name": "C3714749#ent", "pos": [17, 18]}}
{"token": ["This", "animal", "model", "prove", "useful", "in", "subsequent", "in", "vivo", "analysis", "of", "additional", "forms", "of", "C1264041#ent", "<e1>", "and", "in", "the", "development", "of", "C1418544#ent", "<e2>", "2A", "vWD"], "h": {"id": "C1264041", "name": "C1264041#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418544", "name": "C1418544#ent", "pos": [21, 22]}}
{"token": ["Western", "blotting", "in", "vitro", "in", "vivo", "ES", "C0086376#ent", "<e1>", "showed", "only", "C1332807#ent", "<e2>", "recognized", "by", "serum", "pooled", "from", "F.", "hepatica-infected", "animals", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [11, 12]}}
{"token": ["A", "26-year-old", "Bedouin", "with", "moderate", "thrombocytopenia", "enlarged", "spleen", "C0023899#ent", "<e1>", "was", "diagnosed", "as", "having", "C1961835#ent", "<e2>", "on", "the", "presence", "of", "Gaucher", "cells", "the", "bone", "marrow", "biopsy", "enzymatic", "determination", "glucocerebrosidase", "activity"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [14, 15]}}
{"token": ["The", "C1366370#ent", "<e1>", "Ag", "levels", "were", "invariably", "high", "in", "acute", "C0024530#ent", "<e2>", "."], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [10, 11]}}
{"token": ["This", "C0259744#ent", "<e1>", "is", "not", "identical", "with", "that", "found", "in", "C0023895#ent", "<e2>"], "h": {"id": "C0259744", "name": "C0259744#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [10, 11]}}
{"token": ["In", "our", "effort", "to", "search", "for", "effective", "C1413154#ent", "<e1>", "the", "activity", "and", "enantioselectivity", "of", "a", "C2604870#ent", "<e2>", "Sporobolomyces", "salmonicolor", "been", "evaluated", "toward", "the", "reduction", "of", "a", "variety", "of", "ketones", "."], "h": {"id": "C1413154", "name": "C1413154#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2604870", "name": "C2604870#ent", "pos": [15, 16]}}
{"token": ["C3538753#ent", "<e1>", "a", "key", "enzyme", "of", "sphingolipid", "metabolism", "hydrolyzes", "ceramide", "to", "C1420357#ent", "<e2>", "."], "h": {"id": "C3538753", "name": "C3538753#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420357", "name": "C1420357#ent", "pos": [11, 12]}}
{"token": ["The", "pathway", "requires", "the", "C0017337#ent", "<e1>", "for", "any", "of", "three", "nucleoside", "diphosphate", "kinases", "ndk", ",", "pykA", ",", "or", "pykF", ")", "and", "the", "C0017337#ent", "<e1>", "for", "a", "C1740167#ent", "<e1>", "(", "yfbR", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1740167", "name": "C1740167#ent", "pos": [26, 27]}}
{"token": ["The", "microscopic", "findings", "were", "clearly", "different", "in", "the", "six", "patients", "with", "C3496337#ent", "<e1>", "compared", "with", "the", "patient", "with", "C0027726#ent", "<e2>", "who", "presented", "with", "severe", "glomerular", "lesions", "extensive", "crescent", "formation", "."], "h": {"id": "C3496337", "name": "C3496337#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [18, 19]}}
{"token": ["Protein", "sequence", "alignments", "other", "poly(A)", "polymerases", "that", "C0031666#ent", "<e1>", "is", "more", "closely", "related", "to", "Saccharomyces", "cerevisiae", "C1423108#ent", "<e2>", "than", "to", "bovine", "C1423108#ent", "<e2>", "."], "h": {"id": "C0031666", "name": "C0031666#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [16, 17]}}
{"token": ["Combined", "treatment", "of", "C0033860#ent", "<e1>", "with", "methotrexate", "and", "C0015137#ent", "<e2>", "may", "be", "associated", "with", "hepatoxicity", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0015137", "name": "C0015137#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "the", "elevated", "respiratory", "burst", "PMN", "in", "C0033860#ent", "<e1>", "normalizes", "under", "treatment", "with", "both", "C0015137#ent", "<e2>", "and", "CyA."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0015137", "name": "C0015137#ent", "pos": [16, 17]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "assess", "correlates", "of", "treatment", "satisfaction", "patients", "with", "C0017168#ent", "<e1>", "receiving", "a", "proton", "pump", "inhibitor", "C0937846#ent", "<e2>", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0937846", "name": "C0937846#ent", "pos": [21, 22]}}
{"token": ["We", "report", "a", "morphological", "study", "of", "the", "encapsulation", "of", "12-nm", "Fe3O4", "nanoparticles", "(", "C0027341#ent", "<e1>", ")", "in", "large", "unilamellar", "vesicles", "C0216971#ent", "<e2>", "(", "DPPC", ")", "."], "h": {"id": "C0027341", "name": "C0027341#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0216971", "name": "C0216971#ent", "pos": [20, 21]}}
{"token": ["Prior", "to", "admission", ",", "the", "C3890009#ent", "<e1>", "had", "been", "unsuccessfully", "treated", "with", "antibiotics", "and", "C0733383#ent", "<e2>", "."], "h": {"id": "C3890009", "name": "C3890009#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0733383", "name": "C0733383#ent", "pos": [14, 15]}}
{"token": ["The", "relevance", "of", "such", "findings", "to", "human", "neurodegenerative", "conditions", "emphasized", "by", "the", "increased", "C1414968#ent", "<e1>", "in", "postmortem", "samples", "from", "patients", "with", "Parkinson's", "disease", "Alzheimer's", "disease", "Huntington's", "disease", "C0017601#ent", "<e2>", ",", "among", "others", "."], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017601", "name": "C0017601#ent", "pos": [27, 28]}}
{"token": ["C2975867#ent", "<e1>", "by", "casein", "or", "C1823521#ent", "<e2>", "did", "not", "lyse", "any", "of", "the", "tumor", "targets", "tested", "."], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [5, 6]}}
{"token": ["FN-439", "was", "found", "to", "retain", "its", "inhibitory", "activity", "C0623362#ent", "<e1>", "after", "prolonged", "incubation", "with", "pronase", "or", "human", "C0064833#ent", "<e2>", "indicating", "a", "favorite", "candidate", "of", "the", "inhibitor", "to", "modulate", "metalloproteinase", "activities", "in", "vivo"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "in", "the", "rat", "hippocampus", ",", "the", "epileptiform", "activity", "induced", "by", "C0770456#ent", "<e1>", "mediates", "a", "co-ordinated", "expression", "of", "messenger", "RNAs", "C1418388#ent", "<e2>", ",", "nerve", "growth", "factor", "brain-derived", "neurotrophic", "factor"], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418388", "name": "C1418388#ent", "pos": [21, 22]}}
{"token": ["Salvage", "therapy", "patients", "with", "C4084890#ent", "<e1>", "appears", "to", "be", "improved", "when", "doxorubicin", "is", "added", "to", "C0015133#ent", "<e2>", ",", "cisplatin", ",", "and", "bleomycin", "."], "h": {"id": "C4084890", "name": "C4084890#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [15, 16]}}
{"token": ["The", "amino", "acid", "sequence", "to", "putative", "C1417326#ent", "<e1>", "remarkably", "similar", "to", "ABCC1", ",", "C3540577#ent", "<e2>", ",", "ABCC3", ",", "and", "ABCC6", "."], "h": {"id": "C1417326", "name": "C1417326#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540577", "name": "C3540577#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "the", "activation", "of", "IKKalpha", ",", "C1442489#ent", "<e1>", ",", "and", "NIK", "by", "IGF-II", "was", "dependent", "on", "C2936824#ent", "<e2>", "a", "key", "regulator", "of", "myogenesis", "."], "h": {"id": "C1442489", "name": "C1442489#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [17, 18]}}
{"token": ["Suppression", "is", "specific", "for", "disruption", "of", "TOM1", ",", "since", "C1414692#ent", "<e1>", "does", "not", "restore", "wild-type", "growth", "to", "strains", "lacking", "the", "C3811702#ent", "<e2>", "the", "transcriptional", "regulator", "Ngglp", "."], "h": {"id": "C1414692", "name": "C1414692#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811702", "name": "C3811702#ent", "pos": [20, 21]}}
{"token": ["H2RAs", "are", "the", "preferred", "C0035064#ent", "<e1>", "for", "prevention", "of", "stress", "ulcers", "ulcer", "disease", "and", "C0014869#ent", "<e2>", "the", "pediatric", "population"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014869", "name": "C0014869#ent", "pos": [14, 15]}}
{"token": ["This", "may", "be", "indicated", "by", "the", "fact", "that", "chelerythrine", "inhibits", "PKC", "at", "its", "catalytic", "domain", "which", "is", "C1334043#ent", "<e1>", "with", "other", "C0030940#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [21, 22]}}
{"token": ["As", "a", "result", "of", "impaired", "parathyroid", "function", "resection", "of", "the", "parathyroid", "glands", "C1840402#ent", "<e1>", ",", "acute", "or", "C0033806#ent", "<e2>", "develop", "."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033806", "name": "C0033806#ent", "pos": [17, 18]}}
{"token": ["Among", "them", ",", "an", "inactive", "form", "of", "C1840402#ent", "<e1>", "is", "emphasized", ",", "which", "may", "resemble", "some", "cases", "of", "C0033806#ent", "<e2>", "."], "h": {"id": "C1840402", "name": "C1840402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033806", "name": "C0033806#ent", "pos": [18, 19]}}
{"token": ["The", "majority", "of", "tumours", "(", "n", "=", "17", ")", "expressed", "two", "isoforms", "of", "C0014914#ent", "<e1>", "with", "combinations", "of", "C1333926#ent", "<e2>", "IV", "predominant", "(", "7/17", "samples", ")", "."], "h": {"id": "C0014914", "name": "C0014914#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333926", "name": "C1333926#ent", "pos": [18, 19]}}
{"token": ["The", "scopolamine-induced", "disruption", "of", "spatial", "cognition", "been", "previously", "reported", "to", "improve", "not", "only", "by", "cholinomimetics", "but", "also", "by", "C0242889#ent", "<e1>", "as", "L-threo-DOPS", "and", "C0002403#ent", "<e2>", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002403", "name": "C0002403#ent", "pos": [23, 24]}}
{"token": ["To", "report", "a", "case", "of", "C0038160#ent", "<e1>", "a", "hip", "prosthesis", "treated", "with", "oral", "C0663241#ent", "<e2>", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0663241", "name": "C0663241#ent", "pos": [13, 14]}}
{"token": ["ResD-", "and", "ComA-stimulated", "transcription", "requires", "the", "proteolytic", "elimination", "C1824360#ent", "<e1>", "by", "the", "C0101555#ent", "<e2>", "."], "h": {"id": "C1824360", "name": "C1824360#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [12, 13]}}
{"token": ["Proteolysis", "of", "Bora", "requires", "the", "C3896756#ent", "<e1>", "kinase", "activity", "is", "mediated", "by", "C3272739#ent", "<e2>", "."], "h": {"id": "C3896756", "name": "C3896756#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3272739", "name": "C3272739#ent", "pos": [12, 13]}}
{"token": ["Laminin", ",", "a", "component", "of", "basement", "membranes", "is", "necessary", "for", "the", "surface", "expression", "of", "C1416577#ent", "<e1>", "in", "cultured", "retinal", "glial", "cells", "suggesting", "that", "an", "C0600388#ent", "<e2>", "regulates", "the", "function", "of", "glial", "cells"], "h": {"id": "C1416577", "name": "C1416577#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [24, 25]}}
{"token": ["Recent", "biochemical", "and", "genetic", "evidence", "implicated", "at", "least", "three", "C1366894#ent", "<e1>", "PTKs", ")", ",", "Lck", ",", "Fyn", ",", "and", "C1421567#ent", "<e2>", ",", "that", "are", "involved", "in", "the", "initiation", "of", "TCR", "signal", "transduction", "."], "h": {"id": "C1366894", "name": "C1366894#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421567", "name": "C1421567#ent", "pos": [19, 20]}}
{"token": ["Our", "study", "suggests", "that", "PAH", "often", "occurs", "as", "the", "first", "clinical", "manifestation", "C0035435#ent", "<e1>", "needs", "urgent", "medical", "treatment", "plasmapheresis", "in", "addition", "to", "C0010583#ent", "<e2>", "and", "methylprednisolone", "."], "h": {"id": "C0035435", "name": "C0035435#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [22, 23]}}
{"token": ["This", "is", "a", "performance", "evaluation", "on", "the", "implementation", "of", "the", "Cramer-Rao", "lower", "bound", "(", "CRLB", ")", "for", "background", "C0009090#ent", "<e1>", "measurement", "on", "automatic", "target", "recognition", "C3540546#ent", "<e2>", ")", "."], "h": {"id": "C0009090", "name": "C0009090#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3540546", "name": "C3540546#ent", "pos": [25, 26]}}
{"token": ["Ischaemic", "colitis", "associated", "with", "carcinoma", "of", "the", "colorectum", "may", "present", "dramatically", "with", "C0017086#ent", "<e1>", "or", "colonic", "perforation", "the", "C0232353#ent", "<e2>", "severe", "."], "h": {"id": "C0017086", "name": "C0017086#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0232353", "name": "C0232353#ent", "pos": [18, 19]}}
{"token": ["No", "obvious", "candidate", "human", "disease", "for", "C4289986#ent", "<e1>", "the", "role", "(", "if", "any", ")", "of", "C4022022#ent", "<e2>", "of", "this", "gene", "in", "the", "various", "phenotypes", "of", "trisomy", "21", "unknown", "."], "h": {"id": "C4289986", "name": "C4289986#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4022022", "name": "C4022022#ent", "pos": [15, 16]}}
{"token": ["C0010592#ent", "<e1>", ",", "metipred", ",", "imuran", ",", "dopamine", "in", "small", "doses", "C0007209#ent", "<e2>", ",", "and", "antibiotics", "were", "given", "in", "the", "postoperative", "period", ";", "the", "patient", "was", "kept", "on", "artificial", "respiration", "48", "hours", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [11, 12]}}
{"token": ["cDNA-expressed", "CYP2C9", "and", "C1620185#ent", "<e1>", "were", "both", "shown", "to", "O-demethylate", "R-", "and", "C0027396#ent", "<e2>", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [3, 4]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0027396", "name": "C0027396#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "report", "the", "molecular", "cloning", "sequence", "analysis", "human", "C0069879#ent", "<e1>", "and", "the", "localization", "of", "its", "C0079429#ent", "<e2>", "to", "chromosome", "6p12", "22"], "h": {"id": "C0069879", "name": "C0069879#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "the", "Arg-Gly-Asp", "sequence", "introduced", "into", "the", "TNFalpha", "molecule", "the", "side", "effect", "this", "C1333196#ent", "<e1>", "such", "as", "tissue", "injury", "shock", ",", "and", "that", "C0387080#ent", "<e2>", "could", "be", "useful", "for", "systemic", "therapy"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0387080", "name": "C0387080#ent", "pos": [26, 27]}}
{"token": ["Because", "C1421412#ent", "<e1>", "is", "a", "C0017366#ent", "<e2>", "expressed", "at", "the", "neuromuscular", "junction", "we", "hypothesize", "that", "its", "expression", "may", "be", "different", "between", "fast", "and", "slow", "muscles"], "h": {"id": "C1421412", "name": "C1421412#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017366", "name": "C0017366#ent", "pos": [5, 6]}}
{"token": ["In", "this", "paper", ",", "we", "show", "that", "the", "cytoplasmic", "tail", "C1314771#ent", "<e1>", "12", "mediates", "interactions", "with", "the", "C0387990#ent", "<e2>"], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0387990", "name": "C0387990#ent", "pos": [17, 18]}}
{"token": ["We", "have", "studied", "a", "patient", "with", "hypereosinophilic", "syndrome", "C0206141#ent", "<e1>", ")", "who", "initially", "presented", "with", "recurrent", "asthmatic", "attacks", "by", "progressive", "C0013404#ent", "<e2>", "."], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "PT", "and", "C2732002#ent", "<e1>", ":", "act", "were", "more", "sensitive", "than", "C3810569#ent", "<e2>", "activity", "as", "early", "prognostic", "indices", "clinical", "outcome", "OLT", "."], "h": {"id": "C2732002", "name": "C2732002#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [13, 14]}}
{"token": ["Alzheimer's", "disease", "AD", ")", "is", "a", "progressive", "and", "C1285162#ent", "<e1>", "pathophysiologically", "characterized", "by", "the", "accumulation", "of", "beta-amyloid", "peptides", "C1418846#ent", "<e2>", ")", "in", "the", "brain", "."], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418846", "name": "C1418846#ent", "pos": [18, 19]}}
{"token": ["In", "a", "murine", "model", "of", "acute", "ischemia", "caspase-8", "is", "relocated", "into", "the", "nucleus", "of", "apoptotic", "neurons", ",", "where", "it", "cleaves", "C1436356#ent", "<e1>", ",", "a", "member", "of", "the", "C1538577#ent", "<e2>", "in", "DNA", "repair"], "h": {"id": "C1436356", "name": "C1436356#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1538577", "name": "C1538577#ent", "pos": [27, 28]}}
{"token": ["Since", "extensive", "degradation", "may", "be", "required", "to", "present", "complex", "C2697827#ent", "<e1>", ",", "we", "addressed", "whether", "macrophages", "(", "C1333690#ent", "<e2>", "might", "function", "as", "APC", "for", "anti-viral", "cell-mediated", "immune", "responses", "."], "h": {"id": "C2697827", "name": "C2697827#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "C0077533#ent", "<e1>", "(", "5", "microM", ")", "and", "C0016229#ent", "<e2>", "(", "5", "microM", ")", "on", "the", "transmembrane", "ionic", "currents", "compared", "in", "dog", "and", "rabbit", "ventricular", "muscle", "applying", "the", "conventional", "microelectrode", "patch-clamp", "techniques"], "h": {"id": "C0077533", "name": "C0077533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016229", "name": "C0016229#ent", "pos": [10, 11]}}
{"token": ["These", "data", "indicate", "that", "endogenous", "NO", "production", "through", "the", "C0080054#ent", "<e1>", "mechanism", "is", "impaired", "at", "C2316810#ent", "<e2>"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "wortmannin", ",", "an", "C4287680#ent", "<e1>", "did", "not", "affect", "G-CSF-induced", "benefits", "despite", "cancelling", "C0148346#ent", "<e2>", "increase", "."], "h": {"id": "C4287680", "name": "C4287680#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0148346", "name": "C0148346#ent", "pos": [15, 16]}}
{"token": ["These", "crystals", "are", "C0026249#ent", "<e1>", "and", "induce", "protooncogene", "expression", "C0127082#ent", "<e2>", "MMP", ")", "synthesis", "and", "secretion", "in", "human", "fibroblasts", ",", "effects", "that", "are", "specifically", "blocked", "by", "phosphocitrate", "(", "PC", ")", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [9, 10]}}
{"token": ["Nonetheless", ",", "beta-blockers", "are", "preferred", "in", "postinfarct", "patients", "or", "in", "those", "with", "heart", "failure", "C0002965#ent", "<e1>", "a", "contraindication", "to", "C0012315#ent", "<e2>", "in", "the", "absence", "of", "beta-blockade", ")", "."], "h": {"id": "C0002965", "name": "C0002965#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [19, 20]}}
{"token": ["Hereditary", "hypophosphatemic", "rickets", "groups", "together", "X-linked", "hypophosphatemic", "rickets", "XLH", ")", ",", "autosomal", "dominant", "hypophosphatemic", "rickets", "C1705508#ent", "<e1>", ")", "and", "hereditary", "hypophosphatemic", "rickets", "hypercalciuria", "(", "HHRH", ",", "C3899988#ent", "<e2>", "."], "h": {"id": "C1705508", "name": "C1705508#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [26, 27]}}
{"token": ["The", "interaction", "of", "methyl", "methacrylate", "C1417198#ent", "<e1>", ")", "and", "ethylene", "dimethacrylate", "EDMA", ")", "with", "C0000039#ent", "<e2>", "DPPC", ")", "liposomes", "was", "studied", "by", "1H", "and", "13C", "nuclear", "magnetic", "resonance", "spectroscopy", "NMR", ")", "."], "h": {"id": "C1417198", "name": "C1417198#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000039", "name": "C0000039#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", "to", "the", "C0014442#ent", "<e1>", "activities", ",", "mRNA", "levels", "of", "both", "cat2", "and", "C1412610#ent", "<e2>", "were", "enhanced", "under", "oxidative", "stress", "induced", "by", "either", "paraquat", "or", "the", "fungal", "toxin", "cercosporin", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412610", "name": "C1412610#ent", "pos": [14, 15]}}
{"token": ["The", "amphiphile", "lysophosphatidylcholine", "C1418392#ent", "<e1>", ")", "modulates", "the", "activity", "of", "membrane-associated", "C3540790#ent", "<e2>", "such", "as", "phospholipase", "A2", "adenylate", "and", "guanylate", "cyclases", "ATPase", "."], "h": {"id": "C1418392", "name": "C1418392#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["5", "C0052593#ent", "<e1>", "had", "no", "inhibitory", "effect", "on", "C3657721#ent", "<e2>", "or", "MAO-B", "activity", "in", "renal", "membranes", "which", "speaks", "against", "the", "involvement", "of", "MAOs", "in", "the", "observed", "radioligand", "binding", "."], "h": {"id": "C0052593", "name": "C0052593#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3657721", "name": "C3657721#ent", "pos": [8, 9]}}
{"token": ["The", "nicotinic", "cholinergic", "amine", "piperidine", "diminished", "both", "the", "C0013384#ent", "<e1>", "and", "the", "symptomatic", "control", "in", "some", "patients", "with", "C1868675#ent", "<e2>", "levodopa", "."], "h": {"id": "C0013384", "name": "C0013384#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1868675", "name": "C1868675#ent", "pos": [18, 19]}}
{"token": ["Persons", "with", "C1414531#ent", "<e1>", "display", "fewer", "of", "the", "C1539477#ent", "<e2>", "traits", "."], "h": {"id": "C1414531", "name": "C1414531#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [8, 9]}}
{"token": ["Mean", "asymmetry", "increased", "from", "control", "(", "1.94", ")", "through", "C1414531#ent", "<e1>", "(", "2.78", ")", "to", "the", "C1539477#ent", "<e2>", "(", "4.00", ")", "group", "."], "h": {"id": "C1414531", "name": "C1414531#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [16, 17]}}
{"token": ["The", "concentration", "of", "glycerol-3-phosphate", "dehydrogenase", "GPDH", ";", "sn-glycerol-3-phosphate", ":", "NAD(+)", "2-oxidoreductase", "C2741742#ent", "<e1>", "had", "previously", "been", "determined", "to", "be", "regulated", "by", "C3540778#ent", "<e2>", "in", "rat", "brain", "cells", "in", "vivo", "in", "cell", "culture"], "h": {"id": "C2741742", "name": "C2741742#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [21, 22]}}
{"token": ["C0069456#ent", "<e1>", "promoted", "healing", "of", "gastric", "and", "C0013295#ent", "<e2>", "induced", "by", "acetic", "acid", "rats", "."], "h": {"id": "C0069456", "name": "C0069456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [7, 8]}}
{"token": ["Cytochrome", "P450", "1A2", "C1620185#ent", "<e1>", ")", "is", "an", "important", "member", "of", "the", "cytochrome", "P450", "superfamily", "C3541394#ent", "<e2>", "because", "of", "its", "involvement", "in", "the", "metabolism", "of", "some", "carcinogens", "and", "therapeutically", "important", "drugs", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}}
{"token": ["The", "increase", "in", "mortality", "from", "cardiovascular", "disease", "the", "presence", "of", "electrocardiographic", "signs", "left", "ventricular", "hypertrophy", "LVH", ")", "has", "been", "ascribed", "to", "ischaemic", "changes", "in", "the", "C0149721#ent", "<e1>", "in", "the", "absence", "of", "overt", "C1956346#ent", "<e2>"], "h": {"id": "C0149721", "name": "C0149721#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [32, 33]}}
{"token": ["Therefore", ",", "we", "investigated", "the", "presence", "of", "null", "genotypes", "GSTM1", ",", "C1333715#ent", "<e1>", ",", "and", "two", "polymorphisms", "of", "C1134446#ent", "<e2>", "in", "subjects", "with", "Parkinson's", "disease", "in", "a", "reference", "population"], "h": {"id": "C1333715", "name": "C1333715#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [18, 19]}}
{"token": ["GSTs", "(", "C1333715#ent", "<e1>", ",", "GSTM1", ",", "and", "GSTP1", ")", "and", "C1134446#ent", "<e2>", "EPHX1", ")", "were", "also", "genotyped", "."], "h": {"id": "C1333715", "name": "C1333715#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [11, 12]}}
{"token": ["Association", "of", "C0257291#ent", "<e1>", "C0597298#ent", "<e2>", "with", "retinoblastoma", "protein", "discovered", "in", "retinal", "endothelial", "cells", "and", "C0257291#ent", "<e1>", "C0597298#ent", "<e2>", "increased", "retinoblastoma", "phosphorylation", "basal", "and", "VEGF-stimulated", "conditions", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0257291", "name": "C0257291#ent", "pos": [2, 3]}}
{"token": ["Broader", "spectrum", "antibiotics", "were", "used", "more", "commonly", "in", "patients", "with", "C0746102#ent", "<e1>", "discoloured", "sputum", "chest", "signs", "examination", "and", "where", "the", "C1705010#ent", "<e2>", "felt", "antibiotics", "were", "indicated", "."], "h": {"id": "C0746102", "name": "C0746102#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705010", "name": "C1705010#ent", "pos": [20, 21]}}
{"token": ["Mitochondrial", "metabolism", "evaluated", "through", "studies", "of", "the", "oxygen", "consumption", "isolated", "mitochondria", "and", "through", "the", "study", "of", "the", "activities", "of", "the", "C0377349#ent", "<e1>", "and", "malate", "aspartate", "shuttles", "and", "C0001473#ent", "<e2>", "."], "h": {"id": "C0377349", "name": "C0377349#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [27, 28]}}
{"token": ["Two", "new", "C0003308#ent", "<e1>", "BAY", "n7133", "and", "ICI", "153,066", ",", "were", "compared", "with", "C0022625#ent", "<e2>", "in", "treatment", "of", "mice", "challenged", "intraperitoneally", "with", "Cryptococcus", "neoformans"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [13, 14]}}
{"token": ["C0026196#ent", "<e1>", "use", "is", "infrequently", "associated", "with", "C0272178#ent", "<e2>", "onset", "of", "a", "pericardial", "effusion"], "h": {"id": "C0026196", "name": "C0026196#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0272178", "name": "C0272178#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "multiple", "deletions", "are", "the", "molecular", "hallmark", "of", "C0162666#ent", "<e1>", "inherited", "as", "either", "autosomal", "dominant", "C3899988#ent", "<e2>", "traits", "."], "h": {"id": "C0162666", "name": "C0162666#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "mismatch-directed", "anti-recombination", "and", "sensitivity", "to", "methylating", "agents", "required", "C0879290#ent", "<e1>", "and", "Msh6", ",", "but", "not", "C0879392#ent", "<e2>", "."], "h": {"id": "C0879290", "name": "C0879290#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0879392", "name": "C0879392#ent", "pos": [17, 18]}}
{"token": ["It", "has", "been", "shown", "that", "MutS", "homologue", "(", "in", "conjunction", "with", "C0879290#ent", "<e1>", ")", "but", "not", "C0879392#ent", "<e2>", "is", "involved", "in", "generating", "A/T", "base", "substitutions", "in", "somatic", "hypermutation", "."], "h": {"id": "C0879290", "name": "C0879290#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0879392", "name": "C0879392#ent", "pos": [16, 17]}}
{"token": ["We", "report", "on", "two", "patients", "with", "C0587248#ent", "<e1>", "persistent", "hyperinsulinemic", "C0020615#ent", "<e2>", "and", "review", "the", "endocrine", "manifestations", "of", "C0587248#ent", "<e1>"], "h": {"id": "C0587248", "name": "C0587248#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "an", "18-month-old", "boy", "with", "C0587248#ent", "<e1>", "CS", ")", "with", "proven", "partial", "growth", "hormone", "GH", ")", "deficiency", "and", "C0020615#ent", "<e2>", "episodes", "."], "h": {"id": "C0587248", "name": "C0587248#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [19, 20]}}
{"token": ["It", "is", "a", "rare", "idiosyncratic", "reaction", "major", "tranquilizers", ",", "including", "the", "C0031436#ent", "<e1>", ",", "butyrophenones", ",", "and", "thioxanthenes", ";", "haloperidol", "and", "fluphenazine", "enanthate", "C0060580#ent", "<e2>", "the", "drugs", "most", "commonly", "incriminated", "."], "h": {"id": "C0031436", "name": "C0031436#ent", "pos": [11, 12]}, "relation": "chemical_structure_of", "t": {"id": "C0060580", "name": "C0060580#ent", "pos": [23, 24]}}
{"token": ["Thus", "vestibular", "and", "C0152177#ent", "<e1>", "sensory", "neurons", "require", "BDNF", "but", "not", "C1417863#ent", "<e2>", ",", "whereas", "nodose-petrosal", "sensory", "neurons", "require", "both", "BDNF", "and", "C1417863#ent", "<e2>", "."], "h": {"id": "C0152177", "name": "C0152177#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417863", "name": "C1417863#ent", "pos": [11, 12]}}
{"token": ["The", "C2917660#ent", "<e1>", "composition", "of", "the", "twenty-six", "C1136365#ent", "<e2>", "determined", "and", "a", "few", "selected", "proteins", "were", "subjected", "to", "further", "amino", "acid", "sequence", "analysis"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [7, 8]}}
{"token": ["C0032002#ent", "<e1>", "ACTH", "concentration", "gradually", "decreased", "with", "the", "C2926735#ent", "<e2>", "of", "treatment", ",", "and", "the", "drop", "was", "significantly", "higher", "in", "leptin-infused", "than", "control", "rats", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [8, 9]}}
{"token": ["The", "occult", "ectopic", "ACTH", "syndrome", "is", "ACTH-dependent", "hypercortisolemia", "of", "C0032002#ent", "<e1>", "and", "of", "more", "than", "6", "months", "C2926735#ent", "<e2>", "without", "the", "diagnosis", "of", "the", "origin", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [17, 18]}}
{"token": ["There", "are", "also", "sound", "theoretical", "reasons", "C1367551#ent", "<e1>", "may", "be", "of", "benefit", "in", "the", "treatment", "of", "certain", "C0029456#ent", "<e2>", ",", "especially", "in", "combination", "with", "other", "agents", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0029456", "name": "C0029456#ent", "pos": [17, 18]}}
{"token": ["Lung", "flukes", "Paragonimus", "ohirai", "from", "Kinosaki", ",", "Japan", ",", "characterized", "by", "3", "electrophoretic", "variants", ",", "FF", ",", "C3814419#ent", "<e1>", "and", "SS", ",", "of", "glutamic-oxaloacetic", "transaminase", "GOT", ":", "C0684153#ent", "<e2>", "were", "crossed", "in", "the", "laboratory", "."], "h": {"id": "C3814419", "name": "C3814419#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0684153", "name": "C0684153#ent", "pos": [27, 28]}}
{"token": ["Haemoglobin", "H", "disease", "a", "higher", "absolute", "count", "than", "C0005283#ent", "<e1>", "(", "beta", "E", ",", "indicating", "relatively", "better", "compensatory", "erythropoiesis", "C3161174#ent", "<e2>"], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3161174", "name": "C3161174#ent", "pos": [19, 20]}}
{"token": ["A", "63", "year", "old", "woman", "presented", "to", "the", "emergency", "department", "ED", ")", "with", "1", "week", "of", "progressive", "C0013404#ent", "<e1>", ",", "constipation", ",", "and", "C0746674#ent", "<e2>"], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0746674", "name": "C0746674#ent", "pos": [23, 24]}}
{"token": ["Timolol", "was", "the", "first", "C0001645#ent", "<e1>", "be", "used", "as", "an", "C1515995#ent", "<e2>", "to", "date", "remains", "as", "the", "standard", "because", "none", "of", "the", "newer", "beta", "blockers", "found", "to", "be", "more", "effective", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1515995", "name": "C1515995#ent", "pos": [10, 11]}}
{"token": ["Mutations", "in", "the", "C1825812#ent", "<e1>", "exons", "are", "uncommon", "in", "Caucasian", "women", "with", "C0025322#ent", "<e2>", "."], "h": {"id": "C1825812", "name": "C1825812#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025322", "name": "C0025322#ent", "pos": [12, 13]}}
{"token": ["Among", "these", "markers", ",", "blood", "concentrations", "PMN-E", "and", "IL-6", "rapidly", "increased", "and", "peaked", "at", "the", "early", "phase", "of", "C0030305#ent", "<e1>", "CRP", "and", "C1709995#ent", "<e2>", "did", "not", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [18, 19]}, "relation": "disease_has_associated_gene", "t": {"id": "C1709995", "name": "C1709995#ent", "pos": [22, 23]}}
{"token": ["However", ",", "sodium", "hadacidin", "and", "C0051066#ent", "<e1>", ",", "inhibitors", "of", "C0001503#ent", "<e2>", "failed", "to", "elicit", "a", "maturational", "response", "oocytes", "in", "vivo"], "h": {"id": "C0051066", "name": "C0051066#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001503", "name": "C0001503#ent", "pos": [10, 11]}}
{"token": ["C0002598#ent", "<e1>", "(", "2-n-butyl-3-[3,5", "diiodo-4-diethylaminoethoxybenzoyl]-benzofuran", ",", "B2-O-CH(2)CH(2)-N-diethyl", ")", "is", "an", "effective", "C0360703#ent", "<e2>", "potentially", "life-threatening", "organ", "toxicity", "."], "h": {"id": "C0002598", "name": "C0002598#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0360703", "name": "C0360703#ent", "pos": [11, 12]}}
{"token": ["Methylation", "of", "C3539640#ent", "<e1>", "and", "the", "similar", "C1414349#ent", "<e2>", "could", "be", "affected", "using", "single", "site", "mutations", "adjacent", "to", "the", "modification", "site", "demonstrating", "the", "importance", "of", "amino", "acid", "sequence", "PRMT1", "protein", "substrates", "."], "h": {"id": "C3539640", "name": "C3539640#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414349", "name": "C1414349#ent", "pos": [7, 8]}}
{"token": ["Double", "immunodiffusion", "gel", "test", "used", "to", "determine", "the", "antigenic", "composition", "the", "preparations", "of", "membranes", "isolated", "from", "the", "lysozyme", "spheroplasts", "C0017589#ent", "<e1>", "(", "strain", "No.", "10230", ")", "and", "C0025229#ent", "<e2>", "(", "strain", "No.", "C-141", ")", "causative", "agents"], "h": {"id": "C0017589", "name": "C0017589#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0025229", "name": "C0025229#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "administration", "of", "KB-R7943", "caused", "potentiation", "of", "the", "C0003195#ent", "<e1>", "by", "single", "episode", "of", "C1416867#ent", "<e2>", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [15, 16]}}
{"token": ["C0237417#ent", "<e1>", ",", "a", "widely", "used", "C0003299#ent", "<e2>", "can", "alter", "carbohydrate", "tolerance", "and", "acute", "intoxication", "diphenylhydantoin", "can", "be", "associated", "with", "hyperglycemia", "."], "h": {"id": "C0237417", "name": "C0237417#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [6, 7]}}
{"token": ["C0015625#ent", "<e1>", "FA", ")", "is", "an", "autosomal", "recessive", "disorder", "leads", "to", "C0002874#ent", "<e2>"], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [11, 12]}}
{"token": ["Integrin", "binding", "growth", "factor", "receptor", "signaling", "activate", "focal", "adhesion", "kinase", "C0059239#ent", "<e1>", ")", "and", "subsequently", "up-regulate", "C0600388#ent", "<e2>", "ERK-1/2", ")", ",", "leading", "to", "cell-cycle", "progression", "cell", "migration"], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [16, 17]}}
{"token": ["Integrin", "binding", "growth", "factor", "receptor", "signaling", "activate", "C0059239#ent", "<e1>", "FAK", ")", "and", "subsequently", "up-regulate", "C0600388#ent", "<e2>", "ERK-1/2", ")", ",", "leading", "to", "cell-cycle", "progression", "cell", "migration"], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [14, 15]}}
{"token": ["Surgical", "intervention", "often", "necessary", "to", "treat", "either", "the", "C0041327#ent", "<e1>", "its", "sequelae", "such", "as", "destroyed", "lung", ",", "C0014014#ent", "<e2>", "and", "bronchial", "stenosis"], "h": {"id": "C0041327", "name": "C0041327#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014014", "name": "C0014014#ent", "pos": [17, 18]}}
{"token": ["The", "use", "of", "nicotine", "replacement", "therapies", "C0751626#ent", "<e1>", "(", "sustained", "release", "C0700563#ent", "<e2>", ",", "both", "of", "which", "are", "suspected", "of", "exploiting", "dopamine", "'s", "role", "in", "addiction", ",", "enhance", "the", "likelihood", "of", "long-term", "smoking", "cessation"], "h": {"id": "C0751626", "name": "C0751626#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0700563", "name": "C0700563#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "undertaken", "to", "examine", "whether", "prostaglandin", "(", "PG", ")", "inhibition", "with", "indomethacin", "interferes", "with", "angiotensin", "II", "receptor", "blockade", "C0287041#ent", "<e1>", ")", "during", "treatment", "for", "C0020538#ent", "<e2>"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [26, 27]}}
{"token": ["ECG", "LVH", "by", "Cornell", "voltage-duration", "product", "and/or", "Sokolow-Lyon", "voltage", "criteria", "was", "used", "to", "select", "patients", "for", "the", "C0287041#ent", "<e1>", "Intervention", "For", "Endpoint", "(", "LIFE", ")", "Reduction", "in", "C0020538#ent", "<e2>"], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [27, 28]}}
{"token": ["The", "highest", "sensitivity", "to", "correctly", "predict", "the", "true", "C0018790#ent", "<e1>", "type", "was", "found", "for", "SCA5", ",", "SCA7", ",", "and", "C1825850#ent", "<e2>", "."], "h": {"id": "C0018790", "name": "C0018790#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1825850", "name": "C1825850#ent", "pos": [19, 20]}}
{"token": ["The", "renal", "phenotype", "the", "C1419140#ent", "<e1>", "knockout", "mice", "to", "PVALB", "as", "a", "candidate", "C0017337#ent", "<e2>", "for", "GS", "for", "SLC12A3-negative", "cases", "."], "h": {"id": "C1419140", "name": "C1419140#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "provide", "epidemiological", "information", "equine", "C0041227#ent", "<e1>", "in", "the", "Central", "River", "Division", "(", "C0035334#ent", "<e2>", ")", "of", "The", "Gambia", "."], "h": {"id": "C0041227", "name": "C0041227#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [19, 20]}}
{"token": ["Mouse", "gene", "studies", "have", "provided", "unimpeachable", "evidence", "of", "immune-relevant", "functions", "several", "C0163611#ent", "<e1>", "enzymes", "including", "ST6Gal", "I", "C1539859#ent", "<e2>", "and", "ST3Gal", "IV"], "h": {"id": "C0163611", "name": "C0163611#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1539859", "name": "C1539859#ent", "pos": [17, 18]}}
{"token": ["The", "GLP-1-HSA", "bioconjugates", "were", "analyzed", "in", "vitro", "assess", "the", "stabilizing", "effect", "of", "bioconjugation", "in", "the", "presence", "of", "C1447020#ent", "<e1>", "as", "well", "as", "C0061355#ent", "<e2>", "activation", "."], "h": {"id": "C1447020", "name": "C1447020#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0061355", "name": "C0061355#ent", "pos": [22, 23]}}
{"token": ["This", "case", "suggests", "that", "the", "MRI", "characteristics", "of", "C0039082#ent", "<e1>", "those", "of", "C0085543#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [12, 13]}}
{"token": ["The", "cDNA", "encodes", "a", "polypeptide", "of", "442", "C3539946#ent", "<e1>", "to", "the", "C1412792#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412792", "name": "C1412792#ent", "pos": [11, 12]}}
{"token": ["C0151445#ent", "<e1>", "phenomenon", ",", "the", "C1865926#ent", "<e2>", "and", "mild", "arthritis", "also", "often", "part", "of", "the", "syndrome", "."], "h": {"id": "C0151445", "name": "C0151445#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1865926", "name": "C1865926#ent", "pos": [5, 6]}}
{"token": ["Furthermore", ",", "C0013015#ent", "<e1>", "was", "found", "to", "be", "selective", "as", "a", "C3540524#ent", "<e2>", "versus", "alpha", "2-adrenergic", "antagonist", "studied", "on", "the", "dog", "cardioaccelerator", "nerve", ",", "thus", ",", "enhancing", "its", "value", "as", "a", "selective", "DA2", "antagonist"], "h": {"id": "C0013015", "name": "C0013015#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540524", "name": "C3540524#ent", "pos": [11, 12]}}
{"token": ["L-Thyroxine", "(", "T4", ")", "and", "3,3',5-L-triiodothyronine", "(", "T3", ")", "potentiate", "the", "C0003451#ent", "<e1>", "induced", "by", "interferon-gamma(IFN-gamma", ")", "in", "C1334043#ent", "<e2>", "a", "mechanism", "that", "is", "dependent", "upon", "calcium/phospholipid-dependent", "protein", "kinase", "PKC", ")", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["Hereditary", "benign", "telangiectasia", "C0406502#ent", "<e1>", ")", "(", "OMIM", "187260", ")", "is", "a", "C0019247#ent", "<e2>", "characterized", "by", "multiple", "cutaneous", "telangiectases", "in", "the", "first", "years", "of", "life", "in", "various", "locations", "."], "h": {"id": "C0406502", "name": "C0406502#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [12, 13]}}
{"token": ["We", "used", "IR-PCR", "to", "assemble", "constructs", "targeting", "C0072074#ent", "<e1>", ",", "actin", ",", "and", "actin-related", "protein", "C1332114#ent", "<e2>", ")", "transcripts", "from", "Arabidopsis", "."], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332114", "name": "C1332114#ent", "pos": [15, 16]}}
{"token": ["Recruitment", "of", "two", "classes", "of", "HDAC", ",", "C1334032#ent", "<e1>", "and", "HDAC2", ",", "to", "C1417965#ent", "<e2>", "promoter", "region", "in", "situ", "detected", "via", "chromatin", "immunoprecipitation", "ChIP", ")", "analysis", "with", "NMB", "cells"], "h": {"id": "C1334032", "name": "C1334032#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417965", "name": "C1417965#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "human", "monocytes", "with", "C1332789#ent", "<e1>", "and", "MCP-1", "enhanced", "C1823619#ent", "<e2>", "expression", "by", "increased", "hypoxia-inducible", "factor-1alpha", "HIF-1alpha", ")", "expression", "and", "enhanced", "activation", "of", "the", "hypoxia", "response", "element", "HRE", ")", "."], "h": {"id": "C1332789", "name": "C1332789#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1823619", "name": "C1823619#ent", "pos": [10, 11]}}
{"token": ["Heated", "BPA", ",", "on", "the", "other", "hand", ",", "was", "found", "to", "contain", "C0064651#ent", "<e1>", "but", "not", "the", "C0030956#ent", "<e2>", "."], "h": {"id": "C0064651", "name": "C0064651#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}}
{"token": ["Downstream", "from", "C0017097#ent", "<e1>", "activation", ",", "synthesis", "of", "the", "cyclin-cdk", "inhibitor", "C1366618#ent", "<e2>", ",", "is", "suppressed", ",", "thereby", "increasing", "the", "pool", "of", "proliferating", "chondrocytes", "."], "h": {"id": "C0017097", "name": "C0017097#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366618", "name": "C1366618#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", ",", "C0023660#ent", "<e1>", "only", "a", "marginally", "helpful", "therapy", "for", "C0009088#ent", "<e2>"], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009088", "name": "C0009088#ent", "pos": [12, 13]}}
{"token": ["C2607914#ent", "<e1>", "a", "major", "C0264220#ent", "<e2>", "of", "its", "prevalence", ",", "impacts", "on", "quality", "of", "life", "work/school", "performance", ",", "economic", "burden", "and", "links", "with", "asthma", "."], "h": {"id": "C2607914", "name": "C2607914#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0264220", "name": "C0264220#ent", "pos": [4, 5]}}
{"token": ["C0028928#ent", "<e1>", ",", "o-phenanthroline", "and", "leupeptin", "also", "stimulated", "secretion", "of", "radiolabelled", "C1743497#ent", "<e2>", ";", "the", "effects", "of", "inhibitors", "and", "oleate", "were", "additive", ",", "suggesting", "that", "they", "could", "act", "via", "different", "mechanisms", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", "to", "essential", "hypertension", "and", "hyperaldosteronism", "due", "to", "C1621895#ent", "<e1>", "plasma", "aldosterone", "levels", "remain", "unchanged", "in", "tumoral", "hyperaldosteronism", "administrating", "C0006938#ent", "<e2>", "."], "h": {"id": "C1621895", "name": "C1621895#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [20, 21]}}
{"token": ["C1538837#ent", "<e1>", "and", "CT301", "(", "encoding", "Pkn1", "and", "C0238402#ent", "<e2>", ",", "respectively", ")", "were", "expressed", "in", "Escherichia", "coli", "GST", "fusion", "proteins"], "h": {"id": "C1538837", "name": "C1538837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0238402", "name": "C0238402#ent", "pos": [8, 9]}}
{"token": ["Monoclonal", "antibodies", "8/1", ",", "10/10", ",", "and", "25/3", ")", "against", "rat", "C3710929#ent", "<e1>", "used", "for", "the", "immunochemical", "characterization", "of", "this", "C0031727#ent", "<e2>", "."], "h": {"id": "C3710929", "name": "C3710929#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [20, 21]}}
{"token": ["Consistently", ",", "C1413900#ent", "<e1>", "binds", "well", "to", "Mcl-1", "in", "COS", "cells", "C3889446#ent", "<e2>", "."], "h": {"id": "C1413900", "name": "C1413900#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [11, 12]}}
{"token": ["C0017337#ent", "<e1>", "encoding", "chemokine", "receptor-like", "proteins", "been", "found", "in", "C0019340#ent", "<e2>", "and", "poxviruses", "and", "implicated", "in", "viral", "pathogenesis"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019340", "name": "C0019340#ent", "pos": [9, 10]}}
{"token": ["Two", "types", "of", "GS", "isozymes", ",", "located", "in", "the", "cytosol", "(", "C1539652#ent", "<e1>", ")", "and", "in", "the", "C3179066#ent", "<e2>", "(", "GS2", ")", "have", "been", "identified", "in", "plants", "."], "h": {"id": "C1539652", "name": "C1539652#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [17, 18]}}
{"token": ["The", "present", "study", "was", "designed", "to", "investigate", "an", "association", "of", "common", "-588C/T", "and", "-23G/T", "polymorphisms", "within", "C1415098#ent", "<e1>", "susceptibility", "to", "C0004096#ent", "<e2>"], "h": {"id": "C1415098", "name": "C1415098#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [20, 21]}}
{"token": ["In", "order", "to", "ascertain", "the", "role", "of", "C0059037#ent", "<e1>", "in", "vivo", "a", "human", "C0669391#ent", "<e2>", "used", "to", "drive", "the", "expression", "of", "C0059037#ent", "<e1>", "ectopically", "to", "squamous", "epithelial", "cells"], "h": {"id": "C0059037", "name": "C0059037#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669391", "name": "C0669391#ent", "pos": [13, 14]}}
{"token": ["Preliminary", "Superose", "6", "gel", "permeation", "chromatography", "was", "used", "to", "separate", "the", "crosslinked", "beta-", "and", "C0018854#ent", "<e1>", "from", "the", "alpha-chains", "of", "C0009325#ent", "<e2>", "samples", "."], "h": {"id": "C0018854", "name": "C0018854#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [20, 21]}}
{"token": ["Second", ",", "the", "Fc", "receptor", "FcR", ")", "C0018854#ent", "<e1>", "associates", "with", "GP", "VI", "exposure", "to", "C0009325#ent", "<e2>", "does", "not", "associate", "with", "the", "65-kDa", "protein", "."], "h": {"id": "C0018854", "name": "C0018854#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}}
{"token": ["The", "prostate", "produces", "several", "proteases", ",", "the", "most", "abundant", "ones", "being", "C1334308#ent", "<e1>", "KLK3", ",", "PSA", ")", "and", "C0618743#ent", "<e2>", "(", "hK2", ")", ",", "which", "are", "potential", "targets", "for", "tumor", "imaging", "treatment", "."], "h": {"id": "C1334308", "name": "C1334308#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0618743", "name": "C0618743#ent", "pos": [18, 19]}}
{"token": ["The", "neoplasm", "was", "tested", "for", "glial", "fibrillar", "acidic", "protein", "C1415042#ent", "<e1>", ")", ",", "epidermal", "growth", "factor", "receptor", "EGFR", ")", ",", "and", "C1705526#ent", "<e2>", "expression", "."], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [21, 22]}}
{"token": ["induction", "with", "propofol", ",", "thiopental", ",", "C0025668#ent", "<e1>", ",", "etomidate", ",", "and", "C0026056#ent", "<e2>", "in", "patients", "with", "coronary", "artery", "disease", "that", "in", "comparison", "to", "other", "induction", "agents", "propofol", "depressed", "systolic", "diastolic", "arterial", "pressures", "severely", ",", "compromising", "coronary", "perfusion"], "h": {"id": "C0025668", "name": "C0025668#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [12, 13]}}
{"token": ["Three", "patients", "(", "two", "male", ",", "and", "one", "female", ")", "had", "C0020473#ent", "<e1>", "one", "female", "patient", "had", "hyperlipidaemia", "secondary", "to", "C0027145#ent", "<e2>", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027145", "name": "C0027145#ent", "pos": [20, 21]}}
{"token": ["To", "observe", "the", "protective", "effect", "C0022179#ent", "<e1>", "SI", ")", "on", "the", "heart", "function", "the", "rats", "with", "C0014582#ent", "<e2>", "induced", "heart", "failure"], "h": {"id": "C0022179", "name": "C0022179#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [16, 17]}}
{"token": ["The", "case", "is", "reported", "here", "of", "a", "young", "man", "who", "presented", "with", "Pneumocystis", "carinii", "pneumonia", "C1418873#ent", "<e1>", ")", ",", "CD4+", "lymphopenia", "and", "hypogammaglobulinaemia", "attributable", "to", "common", "variable", "immunodeficiency", "C4284230#ent", "<e2>", ")", "."], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4284230", "name": "C4284230#ent", "pos": [28, 29]}}
{"token": ["The", "beta", "chain", "human", "C0005270#ent", "<e1>", "formed", "active", "dimeric", "enzyme", ",", "C1415523#ent", "<e2>", ",", "in", "transformants", "."], "h": {"id": "C0005270", "name": "C0005270#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415523", "name": "C1415523#ent", "pos": [11, 12]}}
{"token": ["These", "results", "reveal", "the", "C1710463#ent", "<e1>", "C1333907#ent", "<e2>", "and", "the", "positive", "contribution", "of", "C1333907#ent", "<e2>", "disruption", "to", "the", "actinorhodin", "biosynthesis", "Streptomyces", "coelicolor"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333907", "name": "C1333907#ent", "pos": [6, 7]}}
{"token": ["When", "patients", "with", "C1420232#ent", "<e1>", "are", "infected", "by", "PVB19", ",", "they", "may", "show", "severe", "C0027947#ent", "<e2>", "and", "mild", "thrombocytopenia", "addition", "to", "severe", "reticulocytopenia", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "the", "synthesis", "of", "C1540309#ent", "<e1>", "begins", "later", "in", "precursor", "B", "cells", "that", "of", "C1413238#ent", "<e2>", ",", "and", "ceases", "before", "the", "terminal", "plasmacyte", "phase"], "h": {"id": "C1540309", "name": "C1540309#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413238", "name": "C1413238#ent", "pos": [17, 18]}}
{"token": ["Bob1", "transactivation", "of", "C1540309#ent", "<e1>", "and", "the", "lack", "of", "this", "transactivation", "of", "C1413238#ent", "<e2>", "account", "for", "the", "differential", "expression", "of", "C1540309#ent", "<e1>", "and", "C1413238#ent", "<e2>", "in", "terminally", "differentiated", "plasma", "cells"], "h": {"id": "C1540309", "name": "C1540309#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413238", "name": "C1413238#ent", "pos": [12, 13]}}
{"token": ["During", "single", "transit", "leukotriene", "C4", "dose-dependent", "increases", "in", "pulmonary", "perfusion", "pressure", "were", "abolished", "by", "FPL-55712", ",", "a", "C3537183#ent", "<e1>", "but", "were", "not", "altered", "significantly", "by", "C0021246#ent", "<e2>", "."], "h": {"id": "C3537183", "name": "C3537183#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [25, 26]}}
{"token": ["The", "peritoneal", "macrophages", "rats", "fed", "cod-liver", "oil", "secreted", "lower", "levels", "of", "C0085078#ent", "<e1>", "elastase", "and", "C0020197#ent", "<e2>", "as", "compared", "to", "those", "from", "rats", "fed", "coconut", "oil", "groundnut", "oil", "diets", "."], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020197", "name": "C0020197#ent", "pos": [15, 16]}}
{"token": ["This", "effect", "of", "C0009014#ent", "<e1>", "was", "abolished", "by", "C3250443#ent", "<e2>", ",", "a", "glucocorticoid", "which", "by", "itself", "had", "little", "effect", "on", "the", "basal", "release", "of", "irANP", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3250443", "name": "C3250443#ent", "pos": [8, 9]}}
{"token": ["The", "splenectomized", "coyote", "had", "generalized", "edema", "C0031256#ent", "<e1>", "renal", "and", "hepatic", "degeneration", "C0017662#ent", "<e2>", "congestion", ",", "extramedullary", "hematopoiesis", "lymphoid", "hyperplasia", "and", "severe", "hemosiderosis", "in", "an", "accessory", "spleen"], "h": {"id": "C0031256", "name": "C0031256#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017662", "name": "C0017662#ent", "pos": [12, 13]}}
{"token": ["Methyl", "[", "5-([4-(2-pyridinyl)-1-piprazinyl", "]", "carbonyl)-1H", "benzimidazole-2-yl", "]", "C0041964#ent", "<e1>", ",", "a", "broad", "spectrum", "C3536838#ent", "<e2>", ",", "was", "tested", "against", "Cysticercus", "fasciolaris", "rats", "and", "the", "cysticercoids", "of", "Hymenolepis", "nana", "beetles", "."], "h": {"id": "C0041964", "name": "C0041964#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536838", "name": "C3536838#ent", "pos": [13, 14]}}
{"token": ["The", "lack", "of", "growth", "on", "C0220918#ent", "<e1>", "and", "the", "C2713546#ent", "<e2>", "in", "transport", "at", "42", "C", "are", "not", "due", "to", "a", "temperature-dependent", "lesion", "either", "the", "electron", "transport", "chain", "in", "Ca2", "+", ",", "Mg2+", "adenosine", "triphosphatase", "."], "h": {"id": "C0220918", "name": "C0220918#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [9, 10]}}
{"token": ["Isotretinoin", "was", "an", "effective", "C0013227#ent", "<e1>", "in", "the", "treatment", "of", "subcorneal", "pustular", "dermatosis", "type", "of", "C1274167#ent", "<e2>", "this", "patient", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1274167", "name": "C1274167#ent", "pos": [15, 16]}}
{"token": ["We", "previously", "demonstrated", "that", "C0035690#ent", "<e1>", "BM", "plasmacytoid", "DC", "(", "C0309720#ent", "<e2>", ")", "differentiation", "into", "CD11b(+", ")", "conventional", "DC", "(", "cDC", ")", "upon", "in", "vitro", "with", "Fms-like", "tyrosine", "kinase", "3", "ligand", "Flt3L", ")", "."], "h": {"id": "C0035690", "name": "C0035690#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0309720", "name": "C0309720#ent", "pos": [10, 11]}}
{"token": ["Although", "the", "pathophysiology", "of", "C0054874#ent", "<e1>", "cystatin", "C", "atherosclerosis", "and", "C0011849#ent", "<e2>", "requires", "further", "investigation", ",", "increased", "serum", "C0054874#ent", "<e1>", "serve", "as", "a", "biomarker", "for", "both", "diseases", "."], "h": {"id": "C0054874", "name": "C0054874#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "low-dose", "C0076840#ent", "<e1>", "constitutes", "an", "alternative", "to", "established", "C0003364#ent", "<e2>"], "h": {"id": "C0076840", "name": "C0076840#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggest", "that", "C0076840#ent", "<e1>", "is", "a", "promising", "C0003364#ent", "<e2>", "a", "coronary", "protective", "effect"], "h": {"id": "C0076840", "name": "C0076840#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [9, 10]}}
{"token": ["Fourteen", "patients", "(", "8", "women", "and", "6", "men", ")", "with", "C0020474#ent", "<e1>", "treated", "with", "micronized", "fenofibrate", "(", "Lipanthyl", "200", "m", ",", "C0238419#ent", "<e2>", ")", "in", "a", "daily", "dose", "200", "mg", "for", "one", "month", "."], "h": {"id": "C0020474", "name": "C0020474#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0238419", "name": "C0238419#ent", "pos": [21, 22]}}
{"token": ["C1336567#ent", "<e1>", "is", "crucial", "for", "the", "activity", "of", "many", "transcription", "factors", "including", "C1413702#ent", "<e2>", ",", "RAR", "and", "CSL/RBP-Jkappa", ",", "but", "the", "role", "for", "C1336567#ent", "<e1>", "in", "neural", "development", "unknown", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1336567", "name": "C1336567#ent", "pos": [0, 1]}}
{"token": ["One", "advantage", "of", "PABD", "is", "to", "prevent", "transfusion-transmitted", "disease", "C0042769#ent", "<e1>", "as", "HIV", "or", "C0042721#ent", "<e2>", "emerging", "virus", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0042721", "name": "C0042721#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "an", "increased", "amount", "of", "C1421431#ent", "<e1>", "was", "bound", "to", "vaults", "isolated", "from", "C0206526#ent", "<e2>"], "h": {"id": "C1421431", "name": "C1421431#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0206526", "name": "C0206526#ent", "pos": [14, 15]}}
{"token": ["Among", "polyanions", ",", "the", "polysaccharides", "heparin", "and", "C0079225#ent", "<e1>", "inhibited", "viral", "infectivity", "C0079225#ent", "<e1>", "the", "most", "effective", "mainly", "towards", "C4288963#ent", "<e1>"], "h": {"id": "C0079225", "name": "C0079225#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4288963", "name": "C4288963#ent", "pos": [19, 20]}}
{"token": ["Serologic", "test", "results", "were", "inconsistent", "with", "those", "associated", "with", "hemolytic", "anemia", "suggested", "that", "hemolysis", "was", "caused", "by", "C0020261#ent", "<e1>", "by", "an", "C0020951#ent", "<e2>", "mechanism", "."], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [21, 22]}}
{"token": ["C1332762#ent", "<e1>", "mRNA", "expression", "could", "be", "blocked", "by", "C0055461#ent", "<e2>", "and", "was", "independent", "of", "protein", "synthesis"], "h": {"id": "C1332762", "name": "C1332762#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [8, 9]}}
{"token": ["Neither", "an", "autosomal", "dominant", "inheritance", "nor", "an", "C3899988#ent", "<e1>", "inheritance", "nor", "a", "C0020476#ent", "<e2>", "unreservedly", "be", "accepted", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020476", "name": "C0020476#ent", "pos": [12, 13]}}
{"token": ["One", "of", "the", "most", "common", "and", "life-threatening", "cardiovascular", "complications", "of", "C0497169#ent", "<e1>", "is", "severe", "global", "left", "ventricular", "dysfunction", "to", "C0026848#ent", "<e2>"], "h": {"id": "C0497169", "name": "C0497169#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [19, 20]}}
{"token": ["Carboxylesterases", "metabolize", "the", "carbamate", "prodrug", "]", "carbonyloxycamptothecin", "(", "CPT-11", ";", "irinotecan", ")", "to", "its", "C1883354#ent", "<e1>", "SN-38", ")", ",", "a", "potent", "C3537239#ent", "<e2>"], "h": {"id": "C1883354", "name": "C1883354#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3537239", "name": "C3537239#ent", "pos": [21, 22]}}
{"token": ["These", "findings", "implicated", "the", "C1333877#ent", "<e1>", "in", "LGL-g", ",", "especially", "C1313497#ent", "<e2>", "as", "the", "agent", "causing", "MBP", "degradation", "."], "h": {"id": "C1333877", "name": "C1333877#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1313497", "name": "C1313497#ent", "pos": [10, 11]}}
{"token": ["Truncation", "mutants", "C1334032#ent", "<e1>", "demonstrated", "that", "binding", "to", "C1426185#ent", "<e2>", "is", "promoted", "by", "S421", "and", "S423", "phosphorylation", "while", "interaction", "with", "RbAp48", "is", "not", "."], "h": {"id": "C1334032", "name": "C1334032#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426185", "name": "C1426185#ent", "pos": [8, 9]}}
{"token": ["C0277528#ent", "<e1>", "antibiotic-associated", "diarrhea", "and", "relapsing", "Clostridium", "difficile", "colitis", "improved", "with", "C1832078#ent", "<e2>", "."], "h": {"id": "C0277528", "name": "C0277528#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1832078", "name": "C1832078#ent", "pos": [11, 12]}}
{"token": ["Manganese", ",", "copper", ",", "and", "especially", "iron", "accelerated", "the", "decomposition", "of", "HPOD", ",", "while", "lithium", ",", "C3714642#ent", "<e1>", ",", "potassium", ",", "magnesium", ",", "calcium", ",", "and", "C0051510#ent", "<e2>", "stabilized", "HPOD", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0051510", "name": "C0051510#ent", "pos": [26, 27]}}
{"token": ["Many", "of", "these", "effects", "seem", "to", "be", "related", "to", "the", "production", "of", "certain", "cytokines", "by", "C0033036#ent", "<e1>", ",", "notably", "IFN-I", "and", "C1334105#ent", "<e2>", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334105", "name": "C1334105#ent", "pos": [21, 22]}}
{"token": ["Mutations", "in", "the", "P450c1", "alpha", "gene", "located", "on", "chromosome", "12", "cause", "1", "alpha-hydroxylase", "deficiency", "also", "known", "as", "C0268689#ent", "<e1>", "an", "autosomal", "recessive", "disease", "by", "C0035579#ent", "<e2>", "and", "impaired", "growth", "due", "to", "failure", "of", "renal", "synthesis", "1,25(OH)2D", "."], "h": {"id": "C0268689", "name": "C0268689#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [24, 25]}}
{"token": ["These", "data", "confirm", "the", "C0339510#ent", "<e1>", "decrease", "observed", "in", "RA", "patients", "treated", "with", "C0025677#ent", "<e2>", "alone", "."], "h": {"id": "C0339510", "name": "C0339510#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "we", "found", "that", "cdk5", "phosphorylates", "dopamine", "and", "cAMP-regulated", "phosphoprotein", "Thr75", ",", "whereas", "C3541431#ent", "<e1>", "responsible", "for", "the", "activation", "of", "cAMP", "response", "element-binding", "protein", "response", "to", "C0215266#ent", "<e2>", "stimulation", "."], "h": {"id": "C3541431", "name": "C3541431#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0215266", "name": "C0215266#ent", "pos": [27, 28]}}
{"token": ["Methylthiopropylamine", "(", "MTPA", ")", ",", "an", "inhibitor", "of", "C1420404#ent", "<e1>", "markedly", "induced", "C0029282#ent", "<e2>", "ODC", ")", "activity", "(", "about", "30-fold", "of", "the", "basal", "level", ")", "in", "human", "lymphoid", "leukemia", "4B", "cells", "."], "h": {"id": "C1420404", "name": "C1420404#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [12, 13]}}
{"token": ["However", ",", "cells", "deficient", "in", "the", "other", "NER", "genes", "C0268138#ent", "<e1>", ",", "XPB", "and", "C1567673#ent", "<e2>", ",", "all", "have", "the", "same", "ratio", "of", "to", "breaks", "as", "wild", "type"], "h": {"id": "C0268138", "name": "C0268138#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1567673", "name": "C1567673#ent", "pos": [14, 15]}}
{"token": ["We", "have", "generated", "two", "C-terminal", "truncation", "mutants", "of", "the", "delta-opioid", "receptor", "the", "final", "15", "or", "37", "C3539946#ent", "<e1>", "examined", "their", "coupling", "to", "PLC", "and", "C1382029#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "indicate", "that", "C0015846#ent", "<e1>", "competitively", "inhibits", "metabolism", "of", "midazolam", "by", "C1142644#ent", "<e2>", "."], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [4, 5]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}}
{"token": ["To", "further", "study", "the", "relationship", "between", "C3814377#ent", "<e1>", "and", "bone", "loss", "we", "analyzed", "the", "bone", "mineral", "density", "C1826421#ent", "<e2>", ")", "in", "relation", "to", "the", "cumulative", "dose", "C3814377#ent", "<e1>", "in", "patients", "who", "had", "undergone", "LT", "."], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3814377", "name": "C3814377#ent", "pos": [6, 7]}}
{"token": ["C0013100#ent", "<e1>", "one", "of", "two", "C0029896#ent", "<e2>", "targeted", "for", "eradication", ",", "the", "other", "being", "polio", "."], "h": {"id": "C0013100", "name": "C0013100#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [5, 6]}}
{"token": ["The", "first", "patient", "had", "to", "be", "sedated", "because", "of", "restlessness", "and", "was", "admitted", "to", "the", "intensive-care", "unit", "intravenous", "C1136254#ent", "<e1>", "the", "second", "became", "comatose", "and", "received", "intravenous", "rehydration", "C0003419#ent", "<e2>", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [28, 29]}}
{"token": ["A", "marked", "reduction", "in", "the", "use", "of", "C1136254#ent", "<e1>", ",", "antitussives", "and", "peroral", "antihistamines", "but", "not", "of", "C0003419#ent", "<e2>", ",", "was", "observed", "in", "late", "summer"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [17, 18]}}
{"token": ["When", "considering", "that", "most", "of", "the", "natural", "C1136254#ent", "<e1>", "peptides", "enhance", "the", "local", "inflammatory", "reaction", "the", "anti-inflammatory", "and", "C0003419#ent", "<e2>", "effects", "of", "alpha-MSH", "confer", "unique", "properties", "to", "this", "molecule", "relative", "to", "other", "natural", "antimicrobial", "molecules"], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [18, 19]}}
{"token": ["Since", "sulfabenzamide", "has", "a", "greater", "hydrophobic", "group", "phenyl", ")", "than", "C0282356#ent", "<e1>", "(", "methyl", ")", ",", "the", "binding", "of", "these", "C0038760#ent", "<e2>", "to", "povidone", "is", "probably", "at", "least", "partially", "hydrophobic", "in", "nature", "."], "h": {"id": "C0282356", "name": "C0282356#ent", "pos": [10, 11]}, "relation": "has_chemical_structure", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "the", "possible", "mechanisms", "of", "paralysis", "and", "recovery", "in", "a", "patient", "with", "the", "acute", "motor", "axonal", "neuropathy", "C3890941#ent", "<e1>", ")", "pattern", "of", "the", "C0018378#ent", "<e2>"], "h": {"id": "C3890941", "name": "C3890941#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [24, 25]}}
{"token": ["The", "current", "histopathological", "aspects", "of", "C0023241#ent", "<e1>", "a", "newly", "discovered", "C0015967#ent", "<e2>", "by", "severe", "rapidly", "progressive", "pneumonias", "with", "20", "%", "mortality", "are", "reviewed", "."], "h": {"id": "C0023241", "name": "C0023241#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [10, 11]}}
{"token": ["The", "PE", "also", "appeared", "effective", "in", "the", "prevention", "and", "treatment", "of", "shock", "and", "C0162770#ent", "<e1>", ",", "but", "much", "less", "so", "for", "installed", "C3854173#ent", "<e2>"], "h": {"id": "C0162770", "name": "C0162770#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [22, 23]}}
{"token": ["The", "literature", "supports", "the", "theory", "that", "use", "of", "proper", "protective", "practices", "equipment", "while", "handling", "C0282559#ent", "<e1>", "provide", "adequate", "protection", "from", "the", "effects", "of", "C0035064#ent", "<e2>", "."], "h": {"id": "C0282559", "name": "C0282559#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [23, 24]}}
{"token": ["Results", "suggest", "that", "personnel", "handling", "C0282559#ent", "<e1>", "subject", "to", "potential", "systemic", "absorption", "these", "C0035064#ent", "<e2>", "by", "inhalation", "."], "h": {"id": "C0282559", "name": "C0282559#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}}
{"token": ["In", "the", "plasma", ",", "C0032144#ent", "<e1>", "PA", ")", "activity", "was", "increased", "in", "the", "C0020473#ent", "<e2>", "and", "arteriosclerotic", "groups", "compared", "to", "control", "group", "however", ",", "the", "activity", "of", "fibrinolysis", "inhibitors", "also", "increased", "."], "h": {"id": "C0032144", "name": "C0032144#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "isolated", "about", "3.2", "kb", "of", "the", "5", "'", "upstream", "of", "the", "human", "C1704952#ent", "<e1>", "further", "characterized", "the", "C1710463#ent", "<e2>", "Ang-2", "."], "h": {"id": "C1704952", "name": "C1704952#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [19, 20]}}
{"token": ["We", "used", "these", "C0035064#ent", "<e1>", "to", "transfect", "two", "prostate", "cancer", "cell", "lines", "C1366526#ent", "<e2>", "and", "G(s)", "alpha", "with", "a", "deoxyribonucleic", "acid", "DNA", ")", "expression", "vector", "generates", "double-stranded", "ribonucleic", "acid", "RNA", ")", "for", "RNA", "interference", "RNAi", ")", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366526", "name": "C1366526#ent", "pos": [12, 13]}}
{"token": ["For", "instance", ",", "depression", "or", "other", "C0087169#ent", "<e1>", "only", "occur", "when", "the", "interval", "between", "C0751495#ent", "<e2>", "is", "greater", "than", "the", "duration", "of", "seizure-induced", "enkephalin", "synthesis.(ABSTRACT", "TRUNCATED", "AT", "400", "WORDS", ")"], "h": {"id": "C0087169", "name": "C0087169#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "BSA", "stimulates", "alpha-MG", "uptake", "and", "its", "action", "is", "partially", "correlated", "with", "C2987155#ent", "<e1>", ",", "MAPK", ",", "or", "C1417708#ent", "<e2>", "primary", "cultured", "PTCs", "."], "h": {"id": "C2987155", "name": "C2987155#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [20, 21]}}
{"token": ["Inhibiting", "protein", "kinase", "C", "calphostin", "C", "exacerbated", "the", "inhibition", "of", "neurite", "initiation", "caused", "by", "PbCI2", ",", "but", "inhibiting", "protein", "kinase", "A", "KT5720", ",", "C1871221#ent", "<e1>", "KN62", ",", "or", "calmodulin", "with", "C0108178#ent", "<e2>", "completely", "reversed", "the", "effects", "of", "."], "h": {"id": "C1871221", "name": "C1871221#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0108178", "name": "C0108178#ent", "pos": [30, 31]}}
{"token": ["The", "authors", "found", "that", "the", "neural", "cell", "adhesion", "molecule", "C1334863#ent", "<e1>", ")", "is", "hyposialylated", "in", "hereditary", "inclusion", "body", "myopathy", "C1853926#ent", "<e2>", ")", "muscle", ",", "as", "suggested", "by", "its", "decreased", "molecular", "weight", "Western", "blot"], "h": {"id": "C1334863", "name": "C1334863#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1853926", "name": "C1853926#ent", "pos": [19, 20]}}
{"token": ["While", "C1417679#ent", "<e1>", "for", "arginine", "biosynthesis", "apparently", "missing", "in", "Chlamydia", ",", "a", "C4042810#ent", "<e2>", "by", "glnP", ",", "glnQ", ",", "and", "artJ", "is", "present", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4042810", "name": "C4042810#ent", "pos": [12, 13]}}
{"token": ["Diphenhydramine", ",", "chlorpheniramine", ",", "C0033405#ent", "<e1>", ",", "cyclizine", ",", "and", "C0008183#ent", "<e2>", "showed", "mild", "antinociceptive", "potency", "."], "h": {"id": "C0033405", "name": "C0033405#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008183", "name": "C0008183#ent", "pos": [10, 11]}}
{"token": ["Intake", "of", "C2936450#ent", "<e1>", "provoke", "skin", "changes", "such", "as", "striae", "distensae", "androgenetic", "alopecia", "hypertrichosis", "and", "C0702166#ent", "<e2>", "."], "h": {"id": "C2936450", "name": "C2936450#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0702166", "name": "C0702166#ent", "pos": [15, 16]}}
{"token": ["Forty", "codons", "of", "the", "RT", "and", "C1335528#ent", "<e1>", "analyzed", "by", "GenotypR", "and", "GeneChip", "for", "C1421416#ent", "<e2>"], "h": {"id": "C1335528", "name": "C1335528#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421416", "name": "C1421416#ent", "pos": [14, 15]}}
{"token": ["The", "relative", "bioavailability", "was", "30", "%", "when", "C0008809#ent", "<e1>", "was", "given", "with", "C0060276#ent", "<e2>"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0060276", "name": "C0060276#ent", "pos": [12, 13]}}
{"token": ["Mammalian", "C0017428#ent", "<e1>", "encode", "two", "imitation", "switch", "family", "chromatin", "remodeling", "proteins", "C1705813#ent", "<e2>", "and", "SNF2L", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705813", "name": "C1705813#ent", "pos": [11, 12]}}
{"token": ["C4084825#ent", "<e1>", "ANG", "II", "formation", ",", "whereas", "rat", "chymase", "rat", "C1422417#ent", "<e2>", "degrades", "ANG", "I", "inactive", "fragments", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1422417", "name": "C1422417#ent", "pos": [10, 11]}}
{"token": ["KU-812", "cells", "are", "thus", "closest", "to", "skin", "mast", "cells", "that", "they", "express", "all", "molecules", "studied", ",", "except", "for", "C4084825#ent", "<e1>", ",", "followed", "by", "THP-1", "cells", "that", "lack", "all", "C1422417#ent", "<e2>"], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1422417", "name": "C1422417#ent", "pos": [28, 29]}}
{"token": ["NPHS1", ",", "which", "encodes", "C1417784#ent", "<e1>", ",", "recently", "has", "been", "identified", "as", "the", "C0079429#ent", "<e2>", "in", "which", "mutations", "cause", "congenital", "nephrotic", "syndrome", "the", "Finnish", "type", "CNF", ")", "."], "h": {"id": "C1417784", "name": "C1417784#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["Taken", "together", ",", "our", "data", "suggest", "that", "C1959603#ent", "<e1>", "represents", "a", "particular", "group", "of", "C0017337#ent", "<e2>", ",", "the", "transcription", "of", "which", "is", "up-regulated", "by", "12/15-LOX", "metabolites", "."], "h": {"id": "C1959603", "name": "C1959603#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "concentration", "of", "C0000294#ent", "<e1>", ",", "the", "composition", "of", "the", "extractant", "solution", "and", "the", "C0085593#ent", "<e2>", "the", "efficiency", "of", "mercury", "extraction", "were", "evaluated", "."], "h": {"id": "C0000294", "name": "C0000294#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085593", "name": "C0085593#ent", "pos": [16, 17]}}
{"token": ["C0001985#ent", "<e1>", "inactivated", "by", "N-tosyl-L-phenylalanine", "chloromethyl", "ketone", "C0040498#ent", "<e2>", ")", ",", "an", "inhibitor", "of", "chymotrypsin", "."], "h": {"id": "C0001985", "name": "C0001985#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040498", "name": "C0040498#ent", "pos": [7, 8]}}
{"token": ["The", "aim", "of", "this", "intervention", "study", "to", "reduce", "significantly", "the", "prevalence", "of", "malaria", "C0242723#ent", "<e1>", "in", "adolescent", "C0030612#ent", "<e2>", "in", "Matola", "and", "Boane", "in", "Mozambique", "."], "h": {"id": "C0242723", "name": "C0242723#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030612", "name": "C0030612#ent", "pos": [17, 18]}}
{"token": ["C1172344#ent", "<e1>", "modulates", "the", "F(1)F(0)-ATPase", ",", "inducing", "the", "formation", "of", "C0038838#ent", "<e2>", "within", "the", "mitochondrial", "respiratory", "chain", "which", "then", "functions", "as", "a", "second", "messenger", "initiating", "apoptosis", "."], "h": {"id": "C1172344", "name": "C1172344#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [10, 11]}}
{"token": ["C1172344#ent", "<e1>", "rapidly", "generated", "C0038838#ent", "<e2>", "(", "O(2)(-", ")", ")", "in", "transformed", "Ramos", "B", "cells", "."], "h": {"id": "C1172344", "name": "C1172344#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [4, 5]}}
{"token": ["The", "response", "of", "these", "cells", "to", "C1172344#ent", "<e1>", "is", "critically", "dependent", "on", "both", "C0038838#ent", "<e2>", "and", "JNK", "activation", "as", "antioxidants", "and", "the", "JNK", "inhibitor", "SP600125", "prevents", "Bax", "translocation", "cytochrome", "c", "release", "and", "cell", "death"], "h": {"id": "C1172344", "name": "C1172344#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [13, 14]}}
{"token": ["Although", "synthetic", "1,2-diglyceride", "(", "C0041073#ent", "<e1>", ")", "dose", "dependently", "stimulated", "endothelin-1", "release", ",", "downregulation", "of", "C1259877#ent", "<e2>", "pretreatment", "with", "phorbol", "ester", "in", "decreased", "effects", "to", "increase", "endothelin-1", "release", "by", "the", "agonists", "."], "h": {"id": "C0041073", "name": "C0041073#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [15, 16]}}
{"token": ["C0041073#ent", "<e1>", "and", "dilinolein", ",", "potent", "activators", "of", "C1259877#ent", "<e2>", "stimulated", "neurite", "outgrowth", "reversed", "the", "inhibitory", "effects", "of", "AMI", "."], "h": {"id": "C0041073", "name": "C0041073#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [8, 9]}}
{"token": ["Thus", ",", "in", "platelets", ",", "binding", "of", "the", "extracellular", "domain", "GP", "IIb-IIIa", "to", "its", "adhesive", "ligand", "initiate", "a", "C0021699#ent", "<e1>", "activates", "intracellular", "C0006784#ent", "<e2>", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [22, 23]}}
{"token": ["There", "are", "three", "papers", "related", "to", "di(2-ethylhexyl)", ",", "one", "to", "di-n-butyl", "phthalate", "two", "to", "C0054293#ent", "<e1>", "one", "to", "ethyl", "phthalyl", "ethyl", "glycolate", "another", "to", "C0012052#ent", "<e2>", "1", ")", "."], "h": {"id": "C0054293", "name": "C0054293#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012052", "name": "C0012052#ent", "pos": [24, 25]}}
{"token": ["PD98059", ",", "an", "inhibitor", "of", "the", "ERK", "pathway", "as", "well", "as", "a", "C1705524#ent", "<e1>", "dominant", "negative", "mutant", "also", "blocked", "C1958958#ent", "<e2>", "activation", "by", "hypoxia", "and", "by", "ionomycin", "."], "h": {"id": "C1705524", "name": "C1705524#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1958958", "name": "C1958958#ent", "pos": [19, 20]}}
{"token": ["Finally", ",", "we", "show", "that", "Notch", "and", "C1705791#ent", "<e1>", "activation", "are", "essential", "for", "C1419771#ent", "<e2>", "DNA", "binding", "and", "osteocalcin", "gene", "expression", "in", "C4", "-", "2B", "cells", "in", "response", "to", "osteogenic", "induction", "."], "h": {"id": "C1705791", "name": "C1705791#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [13, 14]}}
{"token": ["The", "depth", "of", "amblyopia", "was", "strongly", "correlated", "to", "all", "three", "measures", "of", "C0003081#ent", "<e1>", "for", "both", "hyperopic", "and", "C0027092#ent", "<e2>", "individuals", "."], "h": {"id": "C0003081", "name": "C0003081#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027092", "name": "C0027092#ent", "pos": [18, 19]}}
{"token": ["A", "case", "of", "hepatic", "encephalopathy", "a", "C1318485#ent", "<e1>", "child", ",", "who", "has", "undergone", "a", "previous", "mesocaval", "shunt", "C0019154#ent", "<e2>", "is", "presented", "."], "h": {"id": "C1318485", "name": "C1318485#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019154", "name": "C0019154#ent", "pos": [17, 18]}}
{"token": ["Because", "reactive", "oxygen", "species", "been", "implicated", "in", "the", "pathogenesis", "of", "various", "hyperproliferative", "and", "inflammatory", "diseases", "the", "mRNA", "expression", "of", "the", "C1424792#ent", "<e1>", "superoxide", "dismutase", "studied", "in", "C0003872#ent", "<e2>", "skin", "tissue"], "h": {"id": "C1424792", "name": "C1424792#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [26, 27]}}
{"token": ["Dystonia", "is", "both", "a", "symptom", "and", "the", "name", "for", "group", "of", "C0679247#ent", "<e1>", "called", "the", "C0013421#ent", "<e2>", "."], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013421", "name": "C0013421#ent", "pos": [15, 16]}}
{"token": ["This", "may", "be", "a", "possible", "association", "in", "the", "same", "family", "of", "two", "C0012634#ent", "<e1>", ":", "progressive", "external", "ophthalmoplegia", "and", "dominant", "C0338508#ent", "<e2>", "progressive", "hearing", "loss"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0338508", "name": "C0338508#ent", "pos": [20, 21]}}
{"token": ["PGLYRP3", "and", "C1428916#ent", "<e1>", "are", "expressed", "in", "the", "skin", ",", "eyes", ",", "C0036091#ent", "<e2>", "throat", ",", "tongue", ",", "esophagus", ",", "stomach", ",", "and", "intestine", "."], "h": {"id": "C1428916", "name": "C1428916#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [12, 13]}}
{"token": ["In", "fasted", "adrenalectomized", "rats", ",", "corticosterone", "replacement", "increased", "GHRH-R", "mRNA", "levels", "and", "intensified", "the", "C3272715#ent", "<e1>", "decrease", "in", "C1706512#ent", "<e2>", ",", "but", "did", "not", "alter", "NPY", "or", "GHS-R", "response", "."], "h": {"id": "C3272715", "name": "C3272715#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706512", "name": "C1706512#ent", "pos": [18, 19]}}
{"token": ["C1839163#ent", "<e1>", "did", "not", "induce", "chromosomal", "aberrations", "cultured", "Chinese", "hamster", "ovary", "cells", "or", "without", "C1419029#ent", "<e2>", "metabolic", "activation", "enzymes", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419029", "name": "C1419029#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "role", "of", "C1568288#ent", "<e1>", "in", "progressive", "renal", "injury", "the", "gene", "expression", "enzymatic", "activity", "C1568288#ent", "<e1>", "were", "examined", "in", "crescentic", "glomerulonephritis", "induced", "by", "C0403529#ent", "<e1>", "GBM", ")", "antibody", "in", "WKY", "rats", "."], "h": {"id": "C1568288", "name": "C1568288#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0403529", "name": "C0403529#ent", "pos": [25, 26]}}
{"token": ["Back", "pain", "usually", "accompanied", "by", "increased", "C0037763#ent", "<e1>", "so", "centrally-acting", "muscle", "relaxants", "used", "in", "its", "treatment", "together", "with", "C0080151#ent", "<e2>", "."], "h": {"id": "C0037763", "name": "C0037763#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0080151", "name": "C0080151#ent", "pos": [18, 19]}}
{"token": ["Grade", "3/4", "non-hematologic", "toxicities", "included", "grade", "3", "diarrhea", "two", "patients", "(", "dose", "levels", "II", "IV", ")", ",", "C0004093#ent", "<e1>", "one", "patient", "(", "dose", "level", "II", "and", "C0038362#ent", "<e2>", "one", "patient", "(", "dose", "level", ")", "."], "h": {"id": "C0004093", "name": "C0004093#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0038362", "name": "C0038362#ent", "pos": [26, 27]}}
{"token": ["The", "tip", "is", "cooled", "by", "a", "continuous", "flow", "sterile", "saline", "C0086140#ent", "<e1>", "40", ",", "heparin", "and", "C0042071#ent", "<e2>", "."], "h": {"id": "C0086140", "name": "C0086140#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [16, 17]}}
{"token": ["C0024530#ent", "<e1>", "significantly", "increased", "the", "apparent", "K(m", ")", "for", "C1705940#ent", "<e2>", ",", "Tyr", "and", "His", ",", "with", "no", "effect", "K(m)(app", ")", "for", "Phe", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [9, 10]}}
{"token": ["These", "C0035064#ent", "<e1>", "have", "revolutionized", "the", "care", "of", "neovascular", "age", "related", "C0024437#ent", "<e2>", "have", "great", "potential", "for", "other", "blinding", "conditions", "such", "as", "diabetic", "retinopathy", "retinopathy", "of", "prematurity", ",", "and", "neovascular", "glaucoma"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0024437", "name": "C0024437#ent", "pos": [11, 12]}}
{"token": ["The", "unique", "presentation", "of", "microcephaly", ",", "seizures", ",", "ascites", ",", "hepatomegaly", ",", "C1704321#ent", "<e1>", "severe", "developmental", "delay", "observed", "in", "one", "child", "diagnosed", "with", "C2677590#ent", "<e2>", "Ik", "."], "h": {"id": "C1704321", "name": "C1704321#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2677590", "name": "C2677590#ent", "pos": [23, 24]}}
{"token": ["The", "C0073240#ent", "<e1>", "is", "one", "of", "the", "most", "interesting", "families", "of", "C1333398#ent", "<e2>", "."], "h": {"id": "C0073240", "name": "C0073240#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333398", "name": "C1333398#ent", "pos": [11, 12]}}
{"token": ["In", "view", "of", "the", "high", "degree", "of", "similarity", ",", "the", "T-cell", "cDNA", "encodes", "a", "newly", "discovered", "C0085536#ent", "<e1>", ",", "thus", "expanding", "this", "family", "of", "C0017337#ent", "<e2>", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [24, 25]}}
{"token": ["They", "found", "that", "the", "33", "women", "with", "C0002395#ent", "<e1>", "had", "a", "24.2", "%", "frequency", "of", "prior", "C0040128#ent", "<e2>", "comparable", "with", "that", "found", "in", "a", "previous", "epidemiologic", "study"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "the", "catalytic", "activity", "C0012889#ent", "<e1>", "in", "the", "same", "pathway", "as", "C0012890#ent", "<e2>", "and", "this", "is", "consistent", "with", "observation", "that", "DNA", "polymerases", "delta", "epsilon", "colocalize", "in", "some", "punctate", "foci", "yeast", "chromatids", "S", "phase"], "h": {"id": "C0012889", "name": "C0012889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012890", "name": "C0012890#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "C0770893#ent", "<e1>", "does", "not", "affect", "the", "C0027721#ent", "<e2>", "to", "clinical", "diabetes", "this", "animal", "model"], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "we", "show", "that", "tyrosine", "759", "in", "gp130", "is", "essential", "for", "both", "C1706044#ent", "<e1>", "and", "SOCS3", "but", "not", "for", "C1426208#ent", "<e2>", "to", "exert", "their", "inhibitory", "activities", "on", "interleukin-6", "signal", "transduction"], "h": {"id": "C1706044", "name": "C1706044#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1426208", "name": "C1426208#ent", "pos": [20, 21]}}
{"token": ["Histopathological", "muscle", "investigation", "reveals", "a", "more", "or", "less", "characteristic", "C1417685#ent", "<e1>", "pattern", "in", "C0043116#ent", "<e2>", "in", "AHCD", "C1417685#ent", "<e1>", "and", "myopathic", "changes", "are", "variable", "."], "h": {"id": "C1417685", "name": "C1417685#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0043116", "name": "C0043116#ent", "pos": [13, 14]}}
{"token": ["Quadriceps", "muscle", "biopsy", "not", "show", "the", "typical", "C1417685#ent", "<e1>", "pattern", "of", "C0043116#ent", "<e2>"], "h": {"id": "C1417685", "name": "C1417685#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0043116", "name": "C0043116#ent", "pos": [11, 12]}}
{"token": ["C1413247#ent", "<e1>", "CDA", ")", "is", "the", "major", "C0014442#ent", "<e2>", "of", "gemcitabine", "inactivation", "."], "h": {"id": "C1413247", "name": "C1413247#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["The", "deamination", "of", "CPE-C", "to", "cyclopentenyl", "uridine", "C1413247#ent", "<e1>", "investigated", "with", "the", "purified", "C0014442#ent", "<e2>", "from", "human", "placenta", "."], "h": {"id": "C1413247", "name": "C1413247#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["The", "close", "topological", "association", "both", "galactosyltransferase", "and", "thiamine", "pyrophosphatase", "or", "C0069155#ent", "<e1>", "suggests", "a", "concerted", "action", "of", "both", "C3540790#ent", "<e2>", "in", "glycosylation", "."], "h": {"id": "C0069155", "name": "C0069155#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [18, 19]}}
{"token": ["This", "finding", "was", "further", "supported", "when", "an", "additional", "20", "C0078939#ent", "<e1>", "patients", "with", "similar", "clinical", "backgrounds", "showed", "reduced", "CSF", "C1418447#ent", "<e2>", "(", "37", "+", "/-", "13", "pg/ml", ")", "."], "h": {"id": "C0078939", "name": "C0078939#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418447", "name": "C1418447#ent", "pos": [19, 20]}}
{"token": ["C0025007#ent", "<e1>", "often", "accompanies", "diverse", "complications", ",", "including", "C0032310#ent", "<e2>", ",", "otitis", "media", "and", "central", "nervous", "system", "."], "h": {"id": "C0025007", "name": "C0025007#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032310", "name": "C0032310#ent", "pos": [8, 9]}}
{"token": ["C0158252#ent", "<e1>", "one", "of", "the", "most", "common", "C0009326#ent", "<e2>"], "h": {"id": "C0158252", "name": "C0158252#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [7, 8]}}
{"token": ["Exanthematous", "rash", ",", "fever", ",", "eosinophilia", ",", "and", "other", "severe", "reactions", "such", "as", "C0014518#ent", "<e1>", "acute", "vasculitis", "and", "severe", "hepatic", "and", "renal", "dysfunctions", "manifestations", "of", "this", "C1848862#ent", "<e2>", "."], "h": {"id": "C0014518", "name": "C0014518#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [26, 27]}}
{"token": ["R-ras", ",", "K-rev-1/rap", "and", "C1447284#ent", "<e1>", ",", "are", "more", "closely", "related", "to", "prototype", "C1705572#ent", "<e2>", "than", "any", "other", "known", "members", "of", "the", "ras", "superfamily"], "h": {"id": "C1447284", "name": "C1447284#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [13, 14]}}
{"token": ["Point", "mutations", "into", "C1447284#ent", "<e1>", "based", "on", "equivalent", "C1705572#ent", "<e2>", "oncogenic", "mutations", "are", "transforming", "in", "cultured", "cells", "and", "oncogenic", "mutations", "in", "C1447284#ent", "<e1>", "have", "been", "isolated", "from", "several", "human", "tumours", "."], "h": {"id": "C1447284", "name": "C1447284#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [8, 9]}}
{"token": ["There", "are", "at", "least", "two", "types", "of", "cannabinoid", "receptors", "CB1", "and", "C1413555#ent", "<e1>", ",", "both", "coupled", "to", "C0752065#ent", "<e2>", "."], "h": {"id": "C1413555", "name": "C1413555#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0752065", "name": "C0752065#ent", "pos": [17, 18]}}
{"token": ["We", "have", "studied", "the", "modulation", "by", "C0033229#ent", "<e1>", "(", "CPZ", ")", "on", "the", "effects", "of", "lipopolisaccharide", "(", "C0175697#ent", "<e2>", ")", "in", "vivo", "mice", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [17, 18]}}
{"token": ["Cholesterol", "efflux", "partially", "blocked", "by", "C0033229#ent", "<e1>", "and", "hypertonic", "media", "two", "inhibitors", "of", "coated", "C0175697#ent", "<e2>", "endocytosis", "."], "h": {"id": "C0033229", "name": "C0033229#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [14, 15]}}
{"token": ["C0021246#ent", "<e1>", "had", "a", "relative", "affinity", "of", "0.4", "compared", "to", "C0002335#ent", "<e2>", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002335", "name": "C0002335#ent", "pos": [10, 11]}}
{"token": ["At", "high", "concentrations", ",", "C0021246#ent", "<e1>", "and", "mefenamic", "acid", "with", "the", "binding", "of", "C0002335#ent", "<e2>", "to", "a", "broken", "cell", "preparation", "rat", "epididymal", "adipocytes", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002335", "name": "C0002335#ent", "pos": [13, 14]}}
{"token": ["The", "DMSO-induced", "upregulation", "of", "C0694888#ent", "<e1>", "might", "be", "mediated", "by", "C1417708#ent", "<e2>", "which", "was", "evidenced", "by", "the", "blockage", "of", "DMSO-induced", "C0694888#ent", "<e1>", "upregulation", "with", "an", "NF-kappaB", "inhibitor", "pyrrolidine", "dithiocarbamate", "PDTC", ")", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0694888", "name": "C0694888#ent", "pos": [4, 5]}}
{"token": ["These", "new", "thioureas", "showed", "strong", "affinities", "towards", "C0026794#ent", "<e1>", "II", "and", "IV", "of", "carbonic", "anhydrase", "CA", ",", "C2364020#ent", "<e2>", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2364020", "name": "C2364020#ent", "pos": [17, 18]}}
{"token": ["On", "the", "contrary", ",", "as", "is", "the", "case", "for", "C0812246#ent", "<e1>", ",", "the", "LPS-induced", "production", "of", "IL-1", "was", "inhibited", "by", "C0022245#ent", "<e2>", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [20, 21]}}
{"token": ["While", "IGF-I-induced", "activation", "of", "IRS-1", ",", "Shc", ",", "C1705325#ent", "<e1>", "and", "MAPK", "pathways", "unaffected", ",", "IGF-I-inducible", "beta1", "integrin-associated", "kinase", "activity", "association", "of", "C0812252#ent", "<e2>", "with", "p130(CAS", ")", "were", "significantly", "inhibited", "by", "RACK1", "overexpression", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [22, 23]}}
{"token": ["Mutations", "in", "the", "C0919524#ent", "<e1>", "responsible", "for", "the", "autosomal", "recessive", "disorder", "C3711796#ent", "<e2>", "A-T", ")", "."], "h": {"id": "C0919524", "name": "C0919524#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3711796", "name": "C3711796#ent", "pos": [11, 12]}}
{"token": ["In", "parallel", ",", "activities", "of", "acyl", "CoA", "acyl", "transferase", "sn-glycerol-3-phosphate", "acyl", "transferase", "and", "C0023816#ent", "<e1>", "decreased", "and", "activities", "of", "C0063164#ent", "<e2>", "cholesterol", "oleate-ester", "hydrolase", "increased", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0063164", "name": "C0063164#ent", "pos": [19, 20]}}
{"token": ["The", "C2975999#ent", "<e1>", "HMGR", ")", "catalyzes", "the", "conversion", "of", "C1415615#ent", "<e2>", "to", "mevalonic", "acid", "considered", "the", "rate-limiting", "step", "in", "isoprenoid", "biosynthesis"], "h": {"id": "C2975999", "name": "C2975999#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415615", "name": "C1415615#ent", "pos": [9, 10]}}
{"token": ["Improving", "lung", "cancer", "mortality", "has", "remained", "a", "difficult", "C1416596#ent", "<e1>", ";", "however", ",", "therapeutic", "agents", "against", "the", "C1414313#ent", "<e2>", "EGFR", ")", "have", "provided", "physicians", "with", "a", "valuable", "new", "tool", "to", "integrate", "into", "multimodality", "therapy"], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [17, 18]}}
{"token": ["C0030360#ent", "<e1>", "occurs", "both", "as", "a", "C0242634#ent", "<e2>", "as", "a", "condition", "secondary", "to", "lupus", "and", "other", "autoimmune", "diseases"], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242634", "name": "C0242634#ent", "pos": [6, 7]}}
{"token": ["Pharmacological", "inhibition", "of", "C1414805#ent", "<e1>", "activity", "in", "C1337092#ent", "<e2>", "mammary", "epithelial", "cells", "reduced", "cellular", "proliferation", "prevented", "the", "lactogenic", "hormone-induced", "expression", "of", "milk", "proteins"], "h": {"id": "C1414805", "name": "C1414805#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1337092", "name": "C1337092#ent", "pos": [7, 8]}}
{"token": ["Clonidine", "had", "more", "activity", "in", "the", "second", "phase", "of", "the", "formalin", "test", "whereas", "baclofen", ",", "C2350083#ent", "<e1>", ",", "amitryptiline", ",", "ketamine", "and", "C0076829#ent", "<e2>", "showed", "more", "activity", "in", "the", "cold", "plate"], "h": {"id": "C2350083", "name": "C2350083#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0076829", "name": "C0076829#ent", "pos": [22, 23]}}
{"token": ["There", "was", "no", "detectable", "C1414034#ent", "<e1>", "phosphatidylinositol", "monophosphate", "kinase", "activity", "from", "the", "membranes", "after", "the", "C0031667#ent", "<e2>", "treatment", "."], "h": {"id": "C1414034", "name": "C1414034#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [15, 16]}}
{"token": ["We", "have", "examined", "the", "effects", "of", "CMR-like", "particles", "(", "CMR-LPs", ")", "on", "human", "endothelial-cell", "function", ",", "focusing", "on", "the", "C0389003#ent", "<e1>", "(", "COX", ")", "and", "C0907533#ent", "<e2>", "NOS", ")", "pathways", "."], "h": {"id": "C0389003", "name": "C0389003#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [25, 26]}}
{"token": ["We", "also", "identified", "STAT1", ",", "Tyk2", ",", "and", "C0169658#ent", "<e1>", "as", "secondary", "mediators", "IKK-i", "signaling", "as", "a", "result", "of", "C0751599#ent", "<e2>", "production", "in", "these", "cells", "."], "h": {"id": "C0169658", "name": "C0169658#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751599", "name": "C0751599#ent", "pos": [19, 20]}}
{"token": ["The", "response", "of", "45", "severely", "infected", "C0029001#ent", "<e1>", "patients", "to", "relatively", "high", "doses", "C0700531#ent", "<e2>", "DEC-C", ")", "has", "been", "determined", "."], "h": {"id": "C0029001", "name": "C0029001#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0700531", "name": "C0700531#ent", "pos": [13, 14]}}
{"token": ["C1424222#ent", "<e1>", "is", "thought", "to", "be", "engaged", "in", "folding", "of", "nascent", "C1305923#ent", "<e2>", ",", "whereas", "functions", "of", "the", "other", "DnaJ", "homologues", "to", "be", "elucidated", "."], "h": {"id": "C1424222", "name": "C1424222#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [11, 12]}}
{"token": ["Although", "the", "thymocyte", "hybridomas", "did", "not", "grow", "as", "adherent", "cell", "lines", "culture", ",", "constitutive", "cytokine", "production", "required", "engagement", "of", "the", "C1416494#ent", "<e1>", "by", "its", "ligand", "in", "ECM", "C0086376#ent", "<e2>", "."], "h": {"id": "C1416494", "name": "C1416494#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [27, 28]}}
{"token": ["C1706508#ent", "<e1>", "immunostaining", "studies", "revealed", "modest", "tumor", "vasculature", "mice", "expressing", "C3272787#ent", "<e2>", "-", "5", "."], "h": {"id": "C1706508", "name": "C1706508#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272787", "name": "C3272787#ent", "pos": [10, 11]}}
{"token": ["The", "PGK", "STR", "demonstrated", "hemizygosity", ",", "consistent", "with", "C0678928#ent", "<e1>", "with", "an", "absence", "of", "cross-hybridizing", "autosomal", "C4277608#ent", "<e2>", "."], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [16, 17]}}
{"token": ["PP1", ",", "a", "selective", "inhibitor", "of", "the", "C0282625#ent", "<e1>", "reduced", "erythropoietin-induced", "tyrosine", "phosphorylation", "of", "C1333342#ent", "<e2>", "its", "association", "with", "PI3-kinase", "in", "F-36P", "human", "erythroleukaemia", "cells", "."], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333342", "name": "C1333342#ent", "pos": [14, 15]}}
{"token": ["These", "results", "demonstrate", "that", "methamphetamine", "exerts", "a", "C0015967#ent", "<e1>", "DAT", ",", "or", "via", "C1420214#ent", "<e2>", ",", "in", "the", "absence", "of", "DAT", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420214", "name": "C1420214#ent", "pos": [13, 14]}}
{"token": ["The", "clinical", "picture", "C0162838#ent", "<e1>", "closely", "resembled", "that", "of", "C0027822#ent", "<e2>", "neurodermatitis", "or", "lichen", "amyloidosus"], "h": {"id": "C0162838", "name": "C0162838#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027822", "name": "C0027822#ent", "pos": [9, 10]}}
{"token": ["C0162820#ent", "<e1>", "chromate", "is", "reported", "here", "in", "3", "workers", "with", "C0239816#ent", "<e2>", "exposure", "to", "cement", "containing", "iron", "sulfate"], "h": {"id": "C0162820", "name": "C0162820#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0239816", "name": "C0239816#ent", "pos": [10, 11]}}
{"token": ["These", "results", "are", "confirmed", "in", "a", "recent", "X-ray", "crystal", "structure", "C1420426#ent", "<e1>", ",", "a", "highly", "similar", "C1412365#ent", "<e2>", "of", "CS2", "(", "81", "%", "identical", ")", "."], "h": {"id": "C1420426", "name": "C1420426#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412365", "name": "C1412365#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "describe", "two", "C0030940#ent", "<e1>", "CKI", "and", "C1707154#ent", "<e2>", ",", "which", "are", "engaged", "in", "the", "modification", "of", "T.", "cutaneum", "ribosomal", "proteins"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1707154", "name": "C1707154#ent", "pos": [8, 9]}}
{"token": ["Therefore", ",", "C0078459#ent", "<e1>", "seems", "to", "produce", "a", "C0242912#ent", "<e2>", "interacting", ",", "at", "least", "in", "part", ",", "with", "NMDA", "receptor-operated", "Ca2", "+", "channels", "."], "h": {"id": "C0078459", "name": "C0078459#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [8, 9]}}
{"token": ["Cyclobarbital", "inhibited", "C0012010#ent", "<e1>", "metabolism", "by", "rat", "liver", "supernatant", "at", "concentrations", "of", "1", "mM.", "C0015109#ent", "<e2>", "strongly", "inhibited", "by", "C0012010#ent", "<e1>", "in", "a", "non-competitive", "manner", "whereas", "cyclobarbital", "shows", "a", "competitive", "inhibition", "type"], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015109", "name": "C0015109#ent", "pos": [14, 15]}}
{"token": ["The", "expression", "of", "this", "C1335672#ent", "<e1>", "overlaps", "with", "that", "of", "tyrosine", "kinase", "receptors", "C1420874#ent", "<e2>", "and", "Ret", "."], "h": {"id": "C1335672", "name": "C1335672#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420874", "name": "C1420874#ent", "pos": [13, 14]}}
{"token": ["Both", "during", "the", "day", "and", "night", ",", "cortisol", "secretion", "elevated", "during", "C0042291#ent", "<e1>", "infusion", ",", "suggesting", "that", "this", "V1a", "receptor", "antagonist", "agonist", "activity", "the", "C1332123#ent", "<e2>", "the", "pituitary", "involved", "in", "vasopressin-stimulated", "corticotropin", "release", "."], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332123", "name": "C1332123#ent", "pos": [24, 25]}}
{"token": ["In", "a", "second", "paraplegic", "with", "strong", "C4055377#ent", "<e1>", "burst", "firing", "of", "up", "to", "6", "impulses", "with", "increasing", "C1822654#ent", "<e2>", "and", "a", "first", "II", "of", "approx", "."], "h": {"id": "C4055377", "name": "C4055377#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1822654", "name": "C1822654#ent", "pos": [17, 18]}}
{"token": ["Changes", "in", "the", "metabolism", "of", "glycosaminoglycans", "have", "been", "noted", "in", "several", "C0024115#ent", "<e1>", "for", "example", ",", "C0034069#ent", "<e2>", "emphysema", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [16, 17]}}
{"token": ["Together", ",", "these", "findings", "identify", "sequences", "necessary", "for", "T3-induced", "inhibition", "of", "collagen", "type", "I", "promoter", "to", "which", "C0242988#ent", "<e1>", "protein(s", ")", "with", "affinity", "for", "C0812312#ent", "<e2>", "bind", "."], "h": {"id": "C0242988", "name": "C0242988#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [24, 25]}}
{"token": ["C0030486#ent", "<e1>", "induced", "by", "high", "doses", "C2917322#ent", "<e2>", "i.t", ".", ")"], "h": {"id": "C0030486", "name": "C0030486#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2917322", "name": "C2917322#ent", "pos": [6, 7]}}
{"token": ["From", "the", "investigation", "of", "EBV", "titers", ",", "it", "has", "been", "reported", "that", "some", "patients", "with", "C1705240#ent", "<e1>", "develop", "an", "associated", ",", "unusual", "primary", "C0149678#ent", "<e2>"], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [23, 24]}}
{"token": ["Study", "of", "partial", "blockage", "by", "C0016860#ent", "<e1>", "of", "chloride", "currents", "activated", "by", "GABA", "and", "C0017921#ent", "<e2>", "in", "granule", "cells", "us", "to", "distinguish", "two", "populations", "of", "GABA(A)", "receptors", "involved", "in", "granule", "cells", "tonic", "inhibition", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017921", "name": "C0017921#ent", "pos": [14, 15]}}
{"token": ["Renal", "function", "antihypertensive", "drug", "efficacy", "were", "determined", "in", "a", "prospective", ",", "double-blind", ",", "multicenter", "study", "enalapril", "plus", "hydrochlorothiazide", "with", "standard", "triple", "therapy", "hydrochlorothiazide", ",", "C0040233#ent", "<e1>", ",", "and", "hydralazine", ")", "in", "75", "patients", "with", "documented", "C0020538#ent", "<e2>"], "h": {"id": "C0040233", "name": "C0040233#ent", "pos": [24, 25]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [35, 36]}}
{"token": ["The", "effect", "on", "intraocular", "pressure", "IOP", ")", "of", "C0040233#ent", "<e1>", "studied", "in", "30", "patients", "with", "C0020538#ent", "<e2>", "treated", "with", "oral", "alprenolol", "metoprolol", "or", "timolol", "."], "h": {"id": "C0040233", "name": "C0040233#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [15, 16]}}
{"token": ["To", "compare", "the", "efficacy", "of", "C0036078#ent", "<e1>", "(", "SSZ", ")", "with", "its", "two", "moieties", ",", "5-aminosalicylic", "acid", "C3853627#ent", "<e2>", ")", "and", "sulfapyridine", "(", "SP", ")", ",", "in", "patients", "with", "active", "ankylosing", "spondylitis", "AS", ")", "."], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3853627", "name": "C3853627#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "C0017361#ent", "<e1>", "POLG1", "mutations", "are", "responsible", "for", "C0151313#ent", "<e2>", "dysarthria", "and", "ophthalmoplegia", "(", "SANDO", ")", ",", "juvenile", "spino-cerebellar", "ataxia-epilepsy", "syndrome", "(", "SCAE", ")", "and", "Alpers-Huttenlocher", "hepatopathic", "poliodystrophy", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [10, 11]}}
{"token": ["No", "studies", "available", "comparing", "eszopiclone", "with", "similar", "drugs", "like", "C0724725#ent", "<e1>", "(", "Ambien", ")", "or", "zaleplon", "(", "C0876170#ent", "<e2>", ")", "."], "h": {"id": "C0724725", "name": "C0724725#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0876170", "name": "C0876170#ent", "pos": [17, 18]}}
{"token": ["Accompanying", "C0018799#ent", "<e1>", "such", "as", "inner", "ear", "deafness", "G6PDH", "deficiency", "C0020502#ent", "<e2>", "and", "vitamin", "D", "intoxication", "to", "be", "excluded", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020502", "name": "C0020502#ent", "pos": [10, 11]}}
{"token": ["Maximal", "pressor", "response", "to", "C0025681#ent", "<e1>", "was", "attenuated", "in", "the", "fructose-fed", "rats", "given", "C0001047#ent", "<e2>", "relative", "to", "the", "other", "three", "groups", "."], "h": {"id": "C0025681", "name": "C0025681#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [13, 14]}}
{"token": ["VF", "was", "successfully", "prevented", "by", "the", "combination", "of", "C0164155#ent", "<e1>", ",", "propranolol", ",", "and", "C0280858#ent", "<e2>", "."], "h": {"id": "C0164155", "name": "C0164155#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [14, 15]}}
{"token": ["C1306759#ent", "<e1>", "shape", "change", "in", "response", "to", "eotaxin", "was", "inhibited", "by", "C0043167#ent", "<e2>", "but", "indomethacin-", "and", "PGD(2)-induced", "shape", "change", "responses", "were", "not", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "C0043207#ent", "<e1>", "phenotypical", "manifestations", "of", "C0028968#ent", "<e2>"], "h": {"id": "C0043207", "name": "C0043207#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028968", "name": "C0028968#ent", "pos": [8, 9]}}
{"token": ["The", "CABC1", "gene", "also", "called", "C1424564#ent", "<e1>", "or", "ADCK3", ",", "is", "the", "human", "C1334043#ent", "<e2>", "of", "the", "yeast", "ABC1/COQ8", "gene", ",", "one", "of", "the", "numerous", "genes", "involved", "in", "the", "ubiquinone", "biosynthesis", "pathway"], "h": {"id": "C1424564", "name": "C1424564#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}}
{"token": ["The", "CABC1", "gene", "also", "called", "COQ8", "or", "C1424564#ent", "<e1>", ",", "is", "the", "human", "C1334043#ent", "<e2>", "of", "the", "yeast", "ABC1/COQ8", "gene", ",", "one", "of", "the", "numerous", "genes", "involved", "in", "the", "ubiquinone", "biosynthesis", "pathway"], "h": {"id": "C1424564", "name": "C1424564#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}}
{"token": ["A", "similar", "coupling", "of", "C1413555#ent", "<e1>", "to", "a", "mitogenic", "pathway", "to", "the", "regulation", "of", "C1414314#ent", "<e2>", "expression", "was", "also", "observed", "in", "human", "promyelocytic", "cells", "HL60", "."], "h": {"id": "C1413555", "name": "C1413555#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414314", "name": "C1414314#ent", "pos": [14, 15]}}
{"token": ["We", "found", ",", "indeed", ",", "that", "C1705969#ent", "<e1>", "engagement", "inhibits", "STAT6", "activation", "leaving", "unaffected", "the", "C1335877#ent", "<e2>", "level", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335877", "name": "C1335877#ent", "pos": [15, 16]}}
{"token": ["We", "found", ",", "indeed", ",", "that", "C1705969#ent", "<e1>", "engagement", "inhibits", "C1335877#ent", "<e2>", "activation", "leaving", "unaffected", "the", "STAT6", "protein", "level", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335877", "name": "C1335877#ent", "pos": [10, 11]}}
{"token": ["From", "these", "results", ",", "the", "authors", "speculate", "that", "during", "attacks", "of", "C0030305#ent", "<e1>", "the", "pancreas", "liberates", "C0022478#ent", "<e2>", "into", "the", "blood", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022478", "name": "C0022478#ent", "pos": [16, 17]}}
{"token": ["KPC2", "(", "C1424635#ent", "<e1>", "ubiquitylation-promoting", "complex", "2", ")", "together", "with", "KPC1", "forms", "the", "C0077678#ent", "<e2>", "which", "regulates", "degradation", "of", "the", "cyclin-dependent", "kinase", "inhibitor", "p27", "at", "the", "G(1", ")", "phase", "of", "the", "cell", "cycle"], "h": {"id": "C1424635", "name": "C1424635#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [13, 14]}}
{"token": ["We", "report", "here", "three", "high-density", "maps", "of", "variations", "found", "among", "48", "Japanese", "individuals", "in", "three", "C1421347#ent", "<e1>", "UGT", ")", "genes", ",", "UGT2A1", ",", "UGT2B15", ",", "and", "C1570475#ent", "<e2>", "."], "h": {"id": "C1421347", "name": "C1421347#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1570475", "name": "C1570475#ent", "pos": [26, 27]}}
{"token": ["Common", "symptoms", "in", "congenital", "disorders", "glycosylation", "(", "C2930997#ent", "<e1>", ")", "type", "Ia", "are", "muscle", "hypotonia", "cerebellar", "hypoplasia", "C0004134#ent", "<e2>", ",", "mental", "retardation", "ophthalmologic", "involvement", ",", "failure", "to", "thrive", ",", "abnormal", "fat", "distribution", ",", "and", "hepatopathy", "."], "h": {"id": "C2930997", "name": "C2930997#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [17, 18]}}
{"token": ["In", "particular", ",", "in", "phase", "II", "studies", "NCX", "4016", "had", "favorable", "effects", "on", "effort-induced", "endothelial", "dysfunction", "in", "intermittent", "claudication", "and", "on", "C0914069#ent", "<e1>", "parameters", "elicited", "by", "short-term", "C0020456#ent", "<e2>", "in", "type", "II", "diabetics", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [27, 28]}}
{"token": ["Further", "studies", ",", "including", "a", "large", "ongoing", "trial", "of", "normotensive", "patients", "with", "coronary", "artery", "disease", "normal", "left", "ventricular", "function", "may", "also", "establish", "a", "role", "for", "C0072857#ent", "<e1>", "in", "treating", "patients", "with", "C0151744#ent", "<e2>"], "h": {"id": "C0072857", "name": "C0072857#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [31, 32]}}
{"token": ["C1825303#ent", "<e1>", "separable", "from", "flavokinase", "in", "mammals", ",", "prefers", "C1417500#ent", "<e2>", "+", "."], "h": {"id": "C1825303", "name": "C1825303#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [9, 10]}}
{"token": ["The", "hydrolysis", "of", "PIP2", "by", "C0031669#ent", "<e1>", "be", "expected", "to", "result", "in", "the", "disinhibition", "of", "the", "C0220884#ent", "<e2>", "dependent", "phospholipase", "D", "activity", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0220884", "name": "C0220884#ent", "pos": [16, 17]}}
{"token": ["The", "Ca2", "+", "channel", "antagonists", "D600", "and", "C0028066#ent", "<e1>", "inhibited", "the", "effects", "of", "C0012847#ent", "<e2>", "and", "elevated", "K+", "to", "a", "greater", "extent", "than", "that", "of", "muscarine", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012847", "name": "C0012847#ent", "pos": [13, 14]}}
{"token": ["The", "results", "suggest", "that", "the", "top", "of", "C1416867#ent", "<e1>", "contains", "disorganized", "C0009325#ent", "<e2>", "fibrils", "from", "the", "smear", "layer", "degrade", "over", "time", "."], "h": {"id": "C1416867", "name": "C1416867#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}}
{"token": ["C0270724#ent", "<e1>", "a", "rare", "progressive", "disorder", "of", "childhood", "characterized", "by", "mental", "deterioration", "C0036572#ent", "<e2>", "."], "h": {"id": "C0270724", "name": "C0270724#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}}
{"token": ["The", "most", "surprising", "finding", "of", "the", "CD1", "antigen-presenting", "system", "that", "the", "antigens", "presented", "by", "C1413207#ent", "<e1>", "are", "not", "C0030956#ent", "<e2>", ",", "but", "rather", "lipid", "and", "glycolipid", "in", "nature", "."], "h": {"id": "C1413207", "name": "C1413207#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}}
{"token": ["Most", "members", "of", "this", "subset", "recognize", "the", "major", "histocompatibility", "complex", "class", "Ib", "molecule", "C1413207#ent", "<e1>", ";", "their", "heterogeneous", "reactivities", "T", "cell", "receptor", "further", "suggest", "the", "involvement", "of", "C0030956#ent", "<e2>", "and/or", "highly", "variable", "posttranslational", "modifications", "."], "h": {"id": "C1413207", "name": "C1413207#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [27, 28]}}
{"token": ["A", "new", "indolocarbazole", "compound", "C0295217#ent", "<e1>", "(", "1", ")", ",", "modified", "at", "the", "glucose", "group", "a", "C1876722#ent", "<e2>", ",", "J-107,088", "(", "2", ")", ",", "which", "showed", "potent", "anticancer", "activity", "."], "h": {"id": "C0295217", "name": "C0295217#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1876722", "name": "C1876722#ent", "pos": [16, 17]}}
{"token": ["We", "report", "a", "57-year-old", "woman", ",", "with", "progressive", "disseminated", "C0036202#ent", "<e1>", "whose", "eruption", "responded", "to", "treatment", "with", "C0002144#ent", "<e2>", "."], "h": {"id": "C0036202", "name": "C0036202#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002144", "name": "C0002144#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "the", "C2674270#ent", "<e1>", "activated", "transcription", "of", "a", "promoter", "containing", "a", "C1538149#ent", "<e2>", "response", "element"], "h": {"id": "C2674270", "name": "C2674270#ent", "pos": [4, 5]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [13, 14]}}
{"token": ["We", "demonstrate", "that", "C2674270#ent", "<e1>", "can", "interfere", "with", "C1538149#ent", "<e2>", "transcriptional", "repression", "that", "this", "is", "critical", "for", "APL", "pathogenesis", ",", "since", "leukemias", "in", "PLZF(-/-)/PLZF-RARalpha", "mutants", "and", "in", "PLZF-RARalpha/RARalpha-PLZF", "TM", "indistinguishable", "."], "h": {"id": "C2674270", "name": "C2674270#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [8, 9]}}
{"token": ["Three", "synthetic", "peptides", "urotensin", "I", "C0074087#ent", "<e1>", "and", "ovine", "C0022661#ent", "<e2>", ",", "have", "less", "than", "50", "%", "sequence", "homology", "."], "h": {"id": "C0074087", "name": "C0074087#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [9, 10]}}
{"token": ["Synthetic", "ovine", "and", "rat", "C0022661#ent", "<e1>", "and", "C0074087#ent", "<e2>", "showed", "comparable", "C0022661#ent", "<e1>", "potency", "."], "h": {"id": "C0074087", "name": "C0074087#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [4, 5]}}
{"token": ["C0074087#ent", "<e1>", "is", "likewise", "more", "potent", "than", "C0022661#ent", "<e2>", "to", "act", "outside", "the", "brain", "to", "increase", "superior", "mesenteric", "artery", "flow", "plasma", "glucose", "and", "to", "decrease", "mean", "arterial", "pressure"], "h": {"id": "C0074087", "name": "C0074087#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [7, 8]}}
{"token": ["Caspase", "activity", "increased", "with", "the", "addition", "of", "C0057911#ent", "<e1>", "to", "serum-deprived", "MCT", "cells", ",", "but", "C0296871#ent", "<e2>", ",", "a", "caspase", "inhibitor", "did", "not", "inhibit", "cell", "death", "DIDS-treated", ",", "serum-deprived", "MCT", "cells", "."], "h": {"id": "C0057911", "name": "C0057911#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0296871", "name": "C0296871#ent", "pos": [15, 16]}}
{"token": ["USA", "81", ",", "6009", "-", "6013", ")", ",", "C0455988#ent", "<e1>", "stimulates", "the", "C0012892#ent", "<e2>", "in", "vitro", "synthesis", "of", "cII", "protein", "its", "first", "dipeptide", ",", "fMet-Val", "."], "h": {"id": "C0455988", "name": "C0455988#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [12, 13]}}
{"token": ["C3814791#ent", "<e1>", "promoter", "induction", "calcium", "depletion", "partially", "blocked", "by", "dominant-negative", "C1412622#ent", "<e2>", ",", "whereas", "constitutively", "activated", "C1412622#ent", "<e2>", "led", "to", "C3814791#ent", "<e1>", "promoter", "activation"], "h": {"id": "C3814791", "name": "C3814791#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412622", "name": "C1412622#ent", "pos": [10, 11]}}
{"token": ["Late-onset", "muscular", "dystrophies", "C0206157#ent", "<e1>", "may", "be", "mild", "and", "associated", "with", "C0427055#ent", "<e2>", "and", "an", "inability", "to", "increase", "muscle", "mass"], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [11, 12]}}
{"token": ["C0256103#ent", "<e1>", "is", "a", "potent", "inducer", "of", "C0018969#ent", "<e2>", "HO", ")", ",", "which", "catabolizes", "heme", "to", "biliverdin", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018969", "name": "C0018969#ent", "pos": [7, 8]}}
{"token": ["Various", "C0036753#ent", "<e1>", "used", "in", "order", "to", "clarify", "the", "relative", "contribution", "of", "C3536852#ent", "<e2>", ",", "vanilloid", "and", "peroxisome", "proliferator-activated", "receptor", "PEA-induced", "effects", "."], "h": {"id": "C0036753", "name": "C0036753#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536852", "name": "C3536852#ent", "pos": [12, 13]}}
{"token": ["Pcp", "was", "moderately", "active", "against", "E.", "coli", "most", "of", "the", "strains", "belonging", "to", "Bacillus", "spp", "Klebsiella", "spp", "C0036117#ent", "<e1>", "Lactobacillus", "spp", "found", "to", "be", "resistant", "to", "this", "C0013227#ent", "<e2>", "."], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [27, 28]}}
{"token": ["Currently", ",", "3", "C0035064#ent", "<e1>", "are", "available", "in", "the", "US", ":", "ondansetron", ",", "C0543476#ent", "<e2>", "and", "dolasetron", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0543476", "name": "C0543476#ent", "pos": [13, 14]}}
{"token": ["After", "C0065180#ent", "<e1>", "ingestion", "the", "late", "phase", "this", "C0221725#ent", "<e2>", "."], "h": {"id": "C0065180", "name": "C0065180#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0221725", "name": "C0221725#ent", "pos": [8, 9]}}
{"token": ["A", "comparative", "study", "undertaken", "to", "examine", "antihypertensive", "effects", "impact", "of", "hydrochlorothiazide", "(", "HCT", ")", "alone", "or", "in", "combination", "with", "triamterene", "or", "C0002502#ent", "<e1>", "on", "the", "hemodynamics", "of", "79", "patients", "with", "C0020538#ent", "<e2>"], "h": {"id": "C0002502", "name": "C0002502#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [30, 31]}}
{"token": ["The", "MAPK", "gene", "C1825934#ent", "<e1>", ",", "related", "to", "Saccharomyces", "cerevisiae", "MPK1", "and", "Magnaporthe", "grisea", "C1335642#ent", "<e2>", ",", "was", "isolated", "and", "functionally", "characterized"], "h": {"id": "C1825934", "name": "C1825934#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335642", "name": "C1335642#ent", "pos": [14, 15]}}
{"token": ["C0917990#ent", "<e1>", "can", "be", "part", "of", "the", "spectrum", "of", "bony", "erosions", "with", "C0917715#ent", "<e2>"], "h": {"id": "C0917990", "name": "C0917990#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0917715", "name": "C0917715#ent", "pos": [12, 13]}}
{"token": ["No", "genetic", "alteration", "exon", "3", "the", "B", "-catenin", "C0079429#ent", "<e1>", "encoding", "serine/threonine", "rich", "domain", "which", "was", "phosphorylated", "by", "C4283740#ent", "<e2>", "was", "detected", "in", "any", "groups", "of", "the", "endocrine", "tumors"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [18, 19]}}
{"token": ["The", "AtSK", "genes", "are", "plant", "homologues", "the", "Drosophila", "shaggy", "(", "SGG", ")", "C0079429#ent", "<e1>", "and", "the", "mammalian", "Glycogen-Synthase", "Kinase-3", "C4283740#ent", "<e2>", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [19, 20]}}
{"token": ["Moreover", ",", "TNF-alpha", "and", "IL-1", "beta", "upregulated", "the", "release", "of", "sTNFR75", "from", "C1524023#ent", "<e1>", "but", "not", "that", "of", "C1706001#ent", "<e2>", "."], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706001", "name": "C1706001#ent", "pos": [18, 19]}}
{"token": ["No", "changes", "in", "either", "receptor", "number", "dissociation", "constants", "(", "C1839259#ent", "<e1>", ")", "were", "observed", "in", "[125I]FSH", "binding", "to", "ovaries", "of", "C1539696#ent", "<e2>", "rats", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [20, 21]}}
{"token": ["The", "C1822723#ent", "<e1>", "community", "had", "a", "higher", "C0011334#ent", "<e2>", "prevalence", ",", "more", "untreated", "lesions", ",", "fewer", "caries-free", "children", ",", "and", "fewer", "children", "treated", "with", "sealants", "."], "h": {"id": "C1822723", "name": "C1822723#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011334", "name": "C0011334#ent", "pos": [7, 8]}}
{"token": ["The", "bone", "marrow", "study", "only", "C0542035#ent", "<e1>", "the", "evidence", "of", "bone", "marrow", "involvement", "with", "lymphoma", "cells", "thus", "C2987154#ent", "<e2>", "was", "suggested", "."], "h": {"id": "C0542035", "name": "C0542035#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987154", "name": "C2987154#ent", "pos": [17, 18]}}
{"token": ["Lmo1", ",", "Lmo2", ",", "and", "C1416882#ent", "<e1>", "are", "LIM-only", "genes", "identified", "as", "C1334912#ent", "<e2>", "have", "been", "implicated", "in", "the", "control", "of", "cell", "differentiation", "are", "active", "during", "CNS", "development", "."], "h": {"id": "C1416882", "name": "C1416882#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334912", "name": "C1334912#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "C1849722#ent", "<e1>", "did", "not", "affect", "depolarization-dependent", "or", "C3273325#ent", "<e2>", "Erk", "and", "Src", "kinase", "phosphorylation"], "h": {"id": "C1849722", "name": "C1849722#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273325", "name": "C3273325#ent", "pos": [10, 11]}}
{"token": ["Herein", "we", "demonstrate", "that", "activation", "of", "C2985456#ent", "<e1>", "in", "human", "pulmonary", "valve", "endothelial", "cells", "specific", "to", "C1522575#ent", "<e2>", "VEGF", ")", "signaling", "through", "VEGF", "receptor", "2"], "h": {"id": "C2985456", "name": "C2985456#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [16, 17]}}
{"token": ["C0054173#ent", "<e1>", "is", "a", "new", "chemotherapeutic", "agent", "inhibits", "C0010536#ent", "<e2>", "most", "common", "side", "effect", "the", "dose", "limiting", "toxicity", "is", "myalgia", "."], "h": {"id": "C0054173", "name": "C0054173#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [8, 9]}}
{"token": ["Follow-up", "x-ray", "examination", "that", "the", "infiltrates", "resolved", "in", "the", "patients", "with", "C0034074#ent", "<e1>", "C0018799#ent", "<e2>", "but", "persisted", "when", "C0018799#ent", "<e2>", "present", "."], "h": {"id": "C0034074", "name": "C0034074#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [13, 14]}}
{"token": ["CAGp-ephrin-B2", "C0039902#ent", "<e1>", "mice", "show", "sudden", "death", "neonatal", "stages", "C0002949#ent", "<e2>", "to", "defective", "recruitment", "of", "vascular", "smooth", "muscle", "cells", "the", "ascending", "aorta"], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002949", "name": "C0002949#ent", "pos": [9, 10]}}
{"token": ["Total", "TACE", "amounts", "in", "GCF", "were", "higher", "in", "persons", "with", "chronic", "and", "C0031106#ent", "<e1>", "in", "those", "with", "C0017574#ent", "<e2>", "or", "in", "healthy", "persons"], "h": {"id": "C0031106", "name": "C0031106#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017574", "name": "C0017574#ent", "pos": [17, 18]}}
{"token": ["RNA", "polymerase", "studies", "are", "consistent", "with", "transcription", "of", "all", "four", "genes", "by", "the", "same", "C1335440#ent", "<e1>", ",", "but", "do", "not", "clearly", "differentiate", "between", "C0035681#ent", "<e2>", "III", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [23, 24]}}
{"token": ["Together", ",", "these", "results", "identify", "new", "active", "components", "postexudate", "resolution", "traffic", ",", "and", "demonstrate", "that", "C1568094#ent", "<e1>", "and", "PD1", "are", "potent", "C2987634#ent", "<e2>", "for", "resolution", "of", "inflamed", "tissues", "."], "h": {"id": "C1568094", "name": "C1568094#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [21, 22]}}
{"token": ["Plasmin", "is", "a", "serine", "protease", "C1447694#ent", "<e1>", "is", "activated", "from", "C1367553#ent", "<e2>", "by", "several", "plasminogen", "activators"], "h": {"id": "C1447694", "name": "C1447694#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [10, 11]}}
{"token": ["i", ")", "Ganglioside", "GM2", ",", "but", "not", "GM3", "or", "globoside", ",", "interacted", "specifically", "with", "tetraspanin", "C0812444#ent", "<e1>", ",", "and", "such", "a", "complex", "inhibited", "hepatocyte", "growth", "factor", "activation", "of", "C0033681#ent", "<e2>", "a", "dose-dependent", "manner", "."], "h": {"id": "C0812444", "name": "C0812444#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [28, 29]}}
{"token": ["An", "Approvable", "letter", "was", "issued", "for", "C1570232#ent", "<e1>", "(", "pregabalin", ")", "for", "the", "treatment", "of", "post-herpetic", "neuralgia", "C0751074#ent", "<e2>", "and", "partial", "seizures", "in", "adults", "."], "h": {"id": "C1570232", "name": "C1570232#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751074", "name": "C0751074#ent", "pos": [17, 18]}}
{"token": ["The", "efficacy", "of", "two", "doses", "of", "C0527189#ent", "<e1>", "0.1", "%", "was", "compared", "to", "one", "dose", "of", "C0527189#ent", "<e1>", "0.2", "%", "in", "the", "prevention", "of", "ocular", "itching", "associated", "with", "C0009766#ent", "<e1>", "24", "hours", "."], "h": {"id": "C0527189", "name": "C0527189#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [28, 29]}}
{"token": ["The", "factors", "that", "modulate", "the", "transition", "from", "the", "benign", ",", "C0035309#ent", "<e1>", "prematurity", "lesions", "cicatrizing", "(", "scarring", ")", "lesions", "characteristic", "of", "C0035344#ent", "<e2>", "unclear", "."], "h": {"id": "C0035309", "name": "C0035309#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0035344", "name": "C0035344#ent", "pos": [21, 22]}}
{"token": ["In", "summary", ",", "C2984132#ent", "<e1>", "enhanced", "the", "mitogenic", "effect", "response", "of", "hydrogen", "peroxides", "largely", "depending", "on", "the", "dysregulation", "of", "the", "activities", "of", "C0038838#ent", "<e2>", ",", "catalase", "and", "glutathione", "peroxidase", "C2984132#ent", "<e1>", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2984132", "name": "C2984132#ent", "pos": [3, 4]}}
{"token": ["The", "tissue", "distribution", "and", "excretion", "of", "[3H]8-methoxypsoralen", "(", "C0740123#ent", "<e1>", ")", ",", "a", "well-accepted", "therapeutic", "agent", "the", "treatment", "of", "C1419789#ent", "<e2>", ",", "was", "studied", "in", "hairless", "HRA/Skh", "female", "mice", "."], "h": {"id": "C0740123", "name": "C0740123#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [19, 20]}}
{"token": ["Here", ",", "we", "report", "that", "C1421437#ent", "<e1>", "interacts", "directly", "with", "several", "C1336849#ent", "<e2>", "facilitates", "their", "recruitment", "to", "Derlin-1", "."], "h": {"id": "C1421437", "name": "C1421437#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336849", "name": "C1336849#ent", "pos": [11, 12]}}
{"token": ["C1417754#ent", "<e1>", ",", "originally", "discovered", "as", "a", "substrate", "of", "the", "C0282625#ent", "<e2>", "is", "also", "a", "target", "for", "a", "protein", "kinase", "pathway", "in", "epithelial", "cells", "causing", "its", "serine/threonine", "dephosphorylation"], "h": {"id": "C1417754", "name": "C1417754#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [10, 11]}}
{"token": ["The", "administration", "of", "t-PA", "leads", "to", "a", "slightly", "better", "outcome", "than", "does", "the", "administration", "of", "C2987134#ent", "<e1>", "in", "a", "patient", "with", "suspected", "C0340293#ent", "<e2>", "."], "h": {"id": "C2987134", "name": "C2987134#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [22, 23]}}
{"token": ["To", "assess", "the", "incidence", "and", "timing", "of", "cardiac", "rupture", "streptokinase", "(", "C2987134#ent", "<e1>", ")", "administration", "in", "acute", "myocardial", "infarction", "C0340293#ent", "<e2>", ")", "."], "h": {"id": "C2987134", "name": "C2987134#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0340293", "name": "C0340293#ent", "pos": [19, 20]}}
{"token": ["These", "fragments", "can", "be", "resolved", "on", "polyacrylamide-agarose", "gels", "the", "sarcosyl", "cores", "are", "treated", "with", "C0033417#ent", "<e1>", "after", "incubation", "with", "the", "C0012906#ent", "<e2>"], "h": {"id": "C0033417", "name": "C0033417#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [20, 21]}}
{"token": ["Depletion", "of", "mDia2", "induced", "contraction", "at", "aberrant", "sites", "of", "dividing", "cells", "where", "contractile", "ring", "components", "as", "RhoA", ",", "C0027096#ent", "<e1>", ",", "anillin", ",", "and", "phosphorylated", "C1414477#ent", "<e2>", "accumulated", "."], "h": {"id": "C0027096", "name": "C0027096#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414477", "name": "C1414477#ent", "pos": [25, 26]}}
{"token": ["Since", "the", "same", "tumors", "were", "previously", "analysed", "for", "the", "amplification", "of", "C0086661#ent", "<e1>", ",", "ERBB2", "and", "HST/INT2/BCL1", "possible", "associations", "with", "C1704724#ent", "<e2>", "and", "FLG", "amplifications", "were", "looked", "for", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704724", "name": "C1704724#ent", "pos": [20, 21]}}
{"token": ["C0051464#ent", "<e1>", "is", "a", "cytotoxic", "protein", "inactivates", "ribosomes", "by", "C0054741#ent", "<e2>", "a", "single", "phosphodiester", "bond", "on", "the", "3", "'", "side", "of", "G-4325", "in", "eukaryotic", "28", "S", "rRNA"], "h": {"id": "C0051464", "name": "C0051464#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [9, 10]}}
{"token": ["Scopolamine", ",", "mecamylamine", "and", "C0009014#ent", "<e1>", "affected", "both", "P(hit", ")", "and", "P(fa", ")", ";", "C0770456#ent", "<e2>", "and", "idazoxan", "reduced", "P(hit", ")", "without", "affecting", "P(fa", ")", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0770456", "name": "C0770456#ent", "pos": [14, 15]}}
{"token": ["The", "isoelectric", "point", "a", "major", "inhibitor", "is", "6.2", "C2984561#ent", "<e1>", "were", "tolerant", "to", "proteolysis", "by", "trypsin", ",", "chymotrypsin", ",", "C0006217#ent", "<e2>", "and", "endogenous", "pigeonpea", "proteases", "."], "h": {"id": "C2984561", "name": "C2984561#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006217", "name": "C0006217#ent", "pos": [19, 20]}}
{"token": ["Baroreflex", "activation", "was", "performed", "before", "and", "after", "bilateral", "microinjection", "C3280555#ent", "<e1>", "into", "the", "intermediate", "commissural", "C1417869#ent", "<e2>", "(", "0.5", "mm", "lateral", "to", "the", "midline", ")", "."], "h": {"id": "C3280555", "name": "C3280555#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [15, 16]}}
{"token": ["Subsequent", "cDNA", "cloning", "p80", "to", "be", "a", "fusion", "protein", "two", "genes", ",", "the", "novel", "tyrosine", "kinase", "gene", "the", "C1334894#ent", "<e1>", "in", "accordance", "with", "the", "sequence", "of", "the", "C0541106#ent", "<e2>"], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [18, 19]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C0541106", "name": "C0541106#ent", "pos": [27, 28]}}
{"token": ["Monocyte-derived", "dendritic", "cells", "(", "C1413852#ent", "<e1>", ")", "are", "potent", "antigen-presenting", "cells", "C0033036#ent", "<e2>", ")", "."], "h": {"id": "C1413852", "name": "C1413852#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [11, 12]}}
{"token": ["These", "C0022173#ent", "<e1>", "differ", "particularly", "in", "their", "ratio", "of", "C0163401#ent", "<e2>", "/arylesterase", "activities", ",", "one", "form", "having", "a", "ratio", "approximately", "seven", "times", "greater", "than", "the", "other", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0163401", "name": "C0163401#ent", "pos": [9, 10]}}
{"token": ["one", "naphthoquinone", "(", "plumbagin", ")", "and", "five", "C0003174#ent", "<e1>", "(", "alizarin", ",", "purpurin", ",", "C0057135#ent", "<e2>", ",", "emodin", ",", "and", "anthrarufin", ")", ",", "were", "subjected", "to", "electrocoagulation", "."], "h": {"id": "C0003174", "name": "C0003174#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0057135", "name": "C0057135#ent", "pos": [14, 15]}}
{"token": ["The", "interactions", "of", "fish", "sperm", "deoxyribonucleic", "acid", "DNA", ")", "with", "C0003174#ent", "<e1>", ",", "such", "as", "chrysophanol", ",", "physcion", "and", "C0057135#ent", "<e2>", "were", "investigated", "by", "using", "ethidium", "bromide", "EB", ")", "as", "fluorescence", "probe"], "h": {"id": "C0003174", "name": "C0003174#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0057135", "name": "C0057135#ent", "pos": [19, 20]}}
{"token": ["The", "human", "T-lymphotropic", "virus", "type", "I", "HTLV-I", ")", "is", "one", "of", "the", "important", "etiological", "agents", "adult", "C1420651#ent", "<e1>", "of", "HTLV-I", "associated", "C0005956#ent", "<e2>", "or", "tropical", "spastic", "paraparesis"], "h": {"id": "C1420651", "name": "C1420651#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0005956", "name": "C0005956#ent", "pos": [21, 22]}}
{"token": ["These", "trials", "proved", "conclusively", "that", "C3273654#ent", "<e1>", "can", "induce", "C1823791#ent", "<e2>", "in", "horses", "."], "h": {"id": "C3273654", "name": "C3273654#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1823791", "name": "C1823791#ent", "pos": [9, 10]}}
{"token": ["C1689854#ent", "<e1>", "DNA", "ligase", "III", "beta", "which", "are", "generated", "by", "alternative", "splicing", "of", "the", "C1416853#ent", "<e2>", "can", "be", "distinguished", "by", "their", "ability", "to", "bind", "to", "the", "DNA", "repair", "protein", "XRCC1", "."], "h": {"id": "C1689854", "name": "C1689854#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416853", "name": "C1416853#ent", "pos": [14, 15]}}
{"token": ["The", "present", "work", "shed", "light", "on", "the", "molecular", "mechanism", "C2986870#ent", "<e1>", "formation", "seen", "in", "C0442874#ent", "<e2>", "provided", "a", "model", "for", "further", "investigation", "."], "h": {"id": "C2986870", "name": "C2986870#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [14, 15]}}
{"token": ["The", "cytogenetic", "activities", "3", "C1335278#ent", "<e1>", "carbadox", ",", "olaquindox", "and", "C0056641#ent", "<e2>", "were", "examined", "by", "the", "micronucleus", "test"], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0056641", "name": "C0056641#ent", "pos": [10, 11]}}
{"token": ["Mice", "homozygous", "for", "this", "C1822726#ent", "<e1>", "mutation", "have", "now", "been", "shown", "to", "manifest", "C0040034#ent", "<e2>", "."], "h": {"id": "C1822726", "name": "C1822726#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [13, 14]}}
{"token": ["Numerous", "reports", "suggest", "that", "C1333571#ent", "<e1>", "plays", "an", "important", "role", "in", "various", "C0012634#ent", "<e2>"], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}}
{"token": ["Thirty-six", "C0004096#ent", "<e1>", "children", "received", "placebo", "and", "C0086073#ent", "<e2>", "a", "new", "drug", ",", "in", "a", "double-blind", "crossover", "study", "the", "majority", "were", "not", "using", "corticosteroids", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0086073", "name": "C0086073#ent", "pos": [7, 8]}}
{"token": ["Lineage", "analyses", "were", "conducted", "in", "both", "C2987364#ent", "<e1>", "and", "laterality", "mutant", "embryos", "experimentally", "induced", "by", "misexpression", "of", "C1704932#ent", "<e2>", ",", "a", "type", "I", "TGF-beta", "receptor", "shown", "to", "modulate", "left-right", "axis", "determination", "Xenopus", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704932", "name": "C1704932#ent", "pos": [17, 18]}}
{"token": ["C1420120#ent", "<e1>", "formed", "co-immunoprecipitable", "complexes", "with", "C1705335#ent", "<e2>", "in", "solubilizated", "rat", "brain", "extracts", ",", "complexes", "that", "also", "contained", "NMDA", "receptors"], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705335", "name": "C1705335#ent", "pos": [6, 7]}}
{"token": ["Thus", ",", "the", "carboxyl-terminal", "region", "PP", "seems", "to", "be", "the", "most", "important", "part", "of", "the", "C0030956#ent", "<e1>", "for", "high", "affinity", "binding", "to", "C3272391#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3272391", "name": "C3272391#ent", "pos": [22, 23]}}
{"token": ["Beta", "blocking", "agents", "ACE", "inhibitors", "C1562036#ent", "<e1>", "verapamil", "or", "diltiazem", "type", "selective", "imidazoline", "receptor", "C0243192#ent", "<e2>", "reduce", "sympathetic", "activity", "and", ",", "therefore", ",", "may", "have", "a", "beneficial", "effect", "in", "diabetic", "patients", "with", "disturbed", "sympathovagal", "balance", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [14, 15]}}
{"token": ["These", "drugs", "belonging", "to", "5", "groups", "(", "C1562036#ent", "<e1>", "inhibitors", "of", "angiotensin", "converting", "enzymes", "beta-blockers", ",", "alpha-blockers", ",", "C0243192#ent", "<e2>", "of", "imidasoline", "receptors", "were", "compared", "in", "monotherapy", "and", "combined", "therapy", "hypotensive", "activity", "safety", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [18, 19]}}
{"token": ["The", "increased", "production", "and", "excretion", "of", "oxalate", "in", "C0020501#ent", "<e1>", "urolithiasis", ",", "nephrocalcinosis", "with", "renal", "failure", "and", "C0268164#ent", "<e2>"], "h": {"id": "C0020501", "name": "C0020501#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [17, 18]}}
{"token": ["RANTES", "was", "also", "found", "in", "the", "conditioned", "medium", "granuloma", "tissue", "treated", "(", "LPS", "or", "C0011816#ent", "<e1>", ")", "and", "untreated", "(", "C0033770#ent", "<e2>", ")", "rats", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033770", "name": "C0033770#ent", "pos": [20, 21]}}
{"token": ["Much", "research", "remains", "to", "be", "done", "on", "the", "subject", "of", "C0518214#ent", "<e1>", "in", "the", "C0265219#ent", "<e2>", "population", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0265219", "name": "C0265219#ent", "pos": [14, 15]}}
{"token": ["Paykel", "'s", "Interview", "for", "Recent", "Life", "Events", "a", "semistructured", "research", "interview", "covering", "64", "life", "events", "was", "administered", "to", "patients", ",", "not", "during", "the", "C0221423#ent", "<e1>", "while", "on", "remission", ",", "by", "C0279175#ent", "<e2>"], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0279175", "name": "C0279175#ent", "pos": [30, 31]}}
{"token": ["These", "C0086376#ent", "<e1>", "were", "identified", "as", "the", "human", "haptoglobin-related", "protein", "C3533087#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3533087", "name": "C3533087#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "report", "antimitogenic", "mechanisms", "activated", "by", "the", "C1337111#ent", "<e1>", "ACTH", ")", "in", "the", "C1704920#ent", "<e2>", "adrenocortical", "tumor", "cell", "line"], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704920", "name": "C1704920#ent", "pos": [14, 15]}}
{"token": ["Therapeutic", "indications", "urinary", "tract", "infections", "urethral", "and", "C0018081#ent", "<e1>", "traveler's", "diarrhea", "selected", "gram-negative", "respiratory", "bone", "infections", "and", "certain", "C0026918#ent", "<e2>"], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [18, 19]}}
{"token": ["Chewing", "gum", "only", "acts", "as", "a", "salivary", "stimulant", "may", "also", "be", "a", "useful", "vehicle", "for", "some", "agents", "such", "as", "C3541971#ent", "<e1>", ",", "chlorhexidine", "and", "C1161320#ent", "<e2>"], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1161320", "name": "C1161320#ent", "pos": [24, 25]}}
{"token": ["The", "results", "obtained", "indicate", "that", "C0265268#ent", "<e1>", "can", "replace", "Gram", "Stain", "C1705568#ent", "<e2>", "organism", "identification", "in", "gastroduodenal", "mucosa", "specimen", "."], "h": {"id": "C0265268", "name": "C0265268#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705568", "name": "C1705568#ent", "pos": [11, 12]}}
{"token": ["The", "addition", "of", "underivatized", "C1705969#ent", "<e1>", "reduced", "the", "solubility", "of", "C1424635#ent", "<e2>", "and", "SIB", "via", "the", "formation", "of", "an", "insoluble", "complex", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424635", "name": "C1424635#ent", "pos": [10, 11]}}
{"token": ["Both", "CMV", "and", "C0035369#ent", "<e1>", "suppressed", "the", "C1423842#ent", "<e2>", "response", "."], "h": {"id": "C0035369", "name": "C0035369#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [7, 8]}}
{"token": ["Two-hundred", "and", "eighteen", "individuals", "with", "C0038013#ent", "<e1>", "randomly", "assigned", "to", "six", "months", "treatment", "with", "C0020740#ent", "<e2>", "(", "900", "-", "1800", "mg/day", ")", "or", "indomethacin", "(", "75", "-", "150", "mg/day", ")", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [14, 15]}}
{"token": ["Aspirin", "is", "still", "the", "preferred", "treatment", "for", "C0038013#ent", "<e1>", "should", "be", "tried", "before", "C0020740#ent", "<e2>", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [13, 14]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "hepatic", "ischemia-reperfusion", "xanthine", "dehydrogenase", "C1421531#ent", "<e1>", "(", "C0043316#ent", "<e2>", "+", "C1421531#ent", "<e1>", ")", "into", "the", "circulation", "and", "that", "circulating", "C1421531#ent", "<e1>", "damages", "isolated", "perfused", "lung", "."], "h": {"id": "C0043316", "name": "C0043316#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [9, 10]}}
{"token": ["Calcium", "transients", "in", "these", "cells", "appear", "to", "activate", "a", "calmodulin", "regulated", "protease", "attacks", "the", "C0043316#ent", "<e1>", "converting", "it", "to", "a", "C1421531#ent", "<e2>", "of", "superoxide", "generation"], "h": {"id": "C0043316", "name": "C0043316#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [20, 21]}}
{"token": ["The", "activity", "of", "C0043316#ent", "<e1>", "higher", "than", "that", "of", "C1421531#ent", "<e2>", "as", "clearly", "seen", "in", "the", "epithelium", "."], "h": {"id": "C0043316", "name": "C0043316#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [9, 10]}}
{"token": ["On", "the", "other", "hand", ",", "C0032285#ent", "<e1>", "augmentation", "of", "LVP", "and", "C1706240#ent", "<e2>", "activities", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706240", "name": "C1706240#ent", "pos": [11, 12]}}
{"token": ["Striatal", "neurons", "convert", "L-dopa", "to", "dopamine", "(", "DA", ")", "following", "gene", "transfer", "C1413943#ent", "<e1>", "AADC", ")", "via", "adeno-associated", "virus", "C1412056#ent", "<e2>", ")", "in", "parkinsonian", "monkeys", "."], "h": {"id": "C1413943", "name": "C1413943#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412056", "name": "C1412056#ent", "pos": [19, 20]}}
{"token": ["This", "study", "explored", "the", "effects", "of", "RTV", "on", "C1413862#ent", "<e1>", "which", "converts", "C3543418#ent", "<e2>", "1,25(OH)(2)D(3", ")", "]", "to", "its", "inactive", "form", "1,24,25,(OH)(3", ")", "."], "h": {"id": "C1413862", "name": "C1413862#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3543418", "name": "C3543418#ent", "pos": [12, 13]}}
{"token": ["Subsequently", ",", "a", "double", "blind", "study", "assess", "the", "effect", "of", "metoclopramide", "and", "C0055747#ent", "<e1>", "on", "gastric", "emptying", "patients", "with", "C0014869#ent", "<e2>", "carried", "out", "."], "h": {"id": "C0055747", "name": "C0055747#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014869", "name": "C0014869#ent", "pos": [19, 20]}}
{"token": ["In", "this", "case", ",", "C0040034#ent", "<e1>", "was", "shown", "to", "be", "levamisole-related", "by", "rechallenge", "with", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}}
{"token": ["The", "major", "side", "effect", "C0040034#ent", "<e1>", "which", "was", "rapidly", "reversible", "on", "stopping", "the", "C1254351#ent", "<e2>", "."], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}}
{"token": ["3-fold", "greater", "than", "that", "of", "C0026088#ent", "<e1>", "equivalents", "when", "administered", "orally", "in", "C0080298#ent", "<e2>", "or", "gelatin", "capsules", "."], "h": {"id": "C0026088", "name": "C0026088#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [12, 13]}}
{"token": ["C0007947#ent", "<e1>", "is", "a", "sexually", "transmitted", "C0277565#ent", "<e2>", "caused", "by", "Haemophilus", "ducreyi"], "h": {"id": "C0007947", "name": "C0007947#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [6, 7]}}
{"token": ["The", "C1165265#ent", "<e1>", "Rh2", "also", "the", "most", "potently", "inhibited", "the", "C0443534#ent", "<e2>", "release", "from", "RBL-2H3", "cells", "induced", "by", "IgE", "with", "antigen", "."], "h": {"id": "C1165265", "name": "C1165265#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0443534", "name": "C0443534#ent", "pos": [10, 11]}}
{"token": ["We", "show", "that", "Nrarp", "forms", "a", "ternary", "complex", "the", "ICD", "of", "C1334889#ent", "<e1>", "and", "the", "CSL", "protein", ")", "and", "that", "in", "embryos", "C2678527#ent", "<e2>", "promotes", "the", "loss", "of", "ICD", "."], "h": {"id": "C1334889", "name": "C1334889#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2678527", "name": "C2678527#ent", "pos": [22, 23]}}
{"token": ["Proliferation", ",", "cell", "viability", "mineralization", "assays", "and", "mRNA", "levels", "were", "assessed", "for", "type", "I", "III", "collagen", "platelet-derived", "growth", "factor", ",", "basic", "fibroblast", "growth", "factor", "C1522505#ent", "<e1>", ")", ",", "metalloproteinase", "(MMP)-2", "and-8", ",", "and", "C1420705#ent", "<e2>", "metalloproteinases", "(TIMP)-1", "and-2", "."], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1420705", "name": "C1420705#ent", "pos": [33, 34]}}
{"token": ["The", "C0796126#ent", "<e1>", "gastric", "cancer", "cell", "line", "which", "has", "C1367689#ent", "<e2>", "uPAR", ")", "but", "lacks", "uPA", ",", "was", "transfected", "with", "a", "plasmid", "containing", "human", "uPA", "cDNA", "and", "injected", "into", "the", "backs", "of", "SCID", "mice", "."], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367689", "name": "C1367689#ent", "pos": [9, 10]}}
{"token": ["C1527149#ent", "<e1>", "present", "in", "C0001752#ent", "<e2>", "exhibited", "chaperoning", "potential", ",", "as", "indicated", "by", "the", "capture", "of", "C1527149#ent", "<e1>", "present", "in", "C0001752#ent", "<e2>", "on", "the", "surface", "of", "normal", "DCs", "."], "h": {"id": "C1527149", "name": "C1527149#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001752", "name": "C0001752#ent", "pos": [4, 5]}}
{"token": ["As", "detected", "by", "ELISA", ",", "inducible", "C1527149#ent", "<e1>", "was", "dramatically", "increased", "in", "RA", "synovial", "fluid", "C0001752#ent", "<e2>", ")", "vs", "normal", "human", "and", "RA", "sera", "and", "osteoarthritis", "and", "gout", "synovial", "fluid"], "h": {"id": "C1527149", "name": "C1527149#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001752", "name": "C0001752#ent", "pos": [15, 16]}}
{"token": ["Like", "PBIT", ",", "PBISe", "targets", "iNOS", "but", "also", "has", "new", "inhibitory", "properties", "acting", "as", "an", "C1332074#ent", "<e1>", "pathway", "inhibitor", "and", "C0752312#ent", "<e2>", "MAPK", ")", "cascade", "activator", "which", "causes", "decreased", "cancer", "cell", "proliferation", "increased", "apoptosis", "."], "h": {"id": "C1332074", "name": "C1332074#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [20, 21]}}
{"token": ["C0019693#ent", "<e1>", "appears", "to", "affect", "bone", "mineral", "density", "C0007222#ent", "<e2>", "cognition", ",", "with", "some", "age-related", "interactions"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [8, 9]}}
{"token": ["123", "Female", "patients", "suffering", "from", "uncomplicated", "C0018081#ent", "<e1>", "treated", "with", "200", "mg", "or", "400", "mg", "C0014310#ent", "<e2>", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0014310", "name": "C0014310#ent", "pos": [15, 16]}}
{"token": ["He", "initially", "responded", "well", "to", "Epoetin", "alpha", "(", "Eprex", ")", "but", "subsequently", "developed", "C1414438#ent", "<e1>", "antibodies", "and", "pure", "red", "cell", "aplasia", "C1415793#ent", "<e2>", ")", ",", "becoming", "blood", "transfusion", "dependent", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [21, 22]}}
{"token": ["In", "our", "patients", ",", "hyperhomocysteinemia", "is", "considered", "as", "an", "indirect", "consequence", "of", "hyperconsumption", "of", "C0003402#ent", "<e1>", "prolonged", "states", "of", "C1337091#ent", "<e2>"], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [19, 20]}}
{"token": ["The", "activity", "of", "the", "C1418975#ent", "<e1>", "was", "completely", "abolished", "by", "treatment", "with", "C0148290#ent", "<e2>", "pyrophosphatase", "."], "h": {"id": "C1418975", "name": "C1418975#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0148290", "name": "C0148290#ent", "pos": [12, 13]}}
{"token": ["The", "design", "and", "synthesis", "of", "novel", "C0053225#ent", "<e1>", "BAM", ")", "derivatives", "of", "distamycin", "A", "one", "or", "more", "C0034242#ent", "<e2>", "the", "pyrrole", "rings", "the", "latter", "are", "described", "."], "h": {"id": "C0053225", "name": "C0053225#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034242", "name": "C0034242#ent", "pos": [17, 18]}}
{"token": ["We", "have", "also", "shown", "that", "hypokalemic", "C0030443#ent", "<e1>", "hypoKPP", ")", "is", "caused", "by", "mutations", "in", "a", "C0079429#ent", "<e2>", "encoding", "a", "voltage-gated", "calcium", "channel"], "h": {"id": "C0030443", "name": "C0030443#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["Neither", "BCL-x(L", ")", "nor", "C4042483#ent", "<e1>", "delayed", "S", "phase", "in", "cells", "deficient", "in", "C1420433#ent", "<e2>", ",", "thus", "C1420433#ent", "<e2>", "is", "required", "for", "the", "cell", "cycle", "function", "BCL-x(L", ")", "and", "C4042483#ent", "<e1>", "."], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420433", "name": "C1420433#ent", "pos": [13, 14]}}
{"token": ["The", "injections", "of", "C1413167#ent", "<e1>", "stimulated", "significant", "increases", "in", "the", "concentrations", "of", "C3887648#ent", "<e2>", ",", "dopamine", "and", "serotonin", "in", "the", "paraventricular", "nucleus", "of", "C3887648#ent", "<e2>", "and", "serotonin", "in", "the", "dorsal", "supraoptic", "nucleus", "region"], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [12, 13]}}
{"token": ["C1428360#ent", "<e1>", "was", "determined", "from", "the", "previously", "validated", "relation", "C1428360#ent", "<e1>", "=", "C0751039#ent", "<e1>", "x", "0.5", "APV", "and", "the", "adjusted", "measurement", "formula", "C1428360#ent", "<e1>", "=", "C0751039#ent", "<e1>", "x", "0.47", "APV", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [12, 13]}}
{"token": ["Change", "in", "C1428360#ent", "<e1>", "was", "calculated", "as", "the", "product", "of", "cross-sectional", "area", "C0751039#ent", "<e2>", ")", "and", "blood", "flow", "velocity", "a", "large", "pial", "artery"], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [12, 13]}}
{"token": ["Chromatin", "immunoprecipitation", "analysis", "the", "endogenous", "C1420626#ent", "<e1>", "promoter", "showed", "increased", "association", "of", "p53", ",", "coactivators", "(", "C1337090#ent", "<e2>", "and", "TRRAP", ")", ",", "and", "acetylated", "histones", "cell", "irradiation"], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1337090", "name": "C1337090#ent", "pos": [16, 17]}}
{"token": ["Patients", "with", "necrotizing", "external", "C0699744#ent", "<e1>", "complain", "of", "severe", "C0004604#ent", "<e2>", "that", "worsens", "at", "night", ",", "and", "otorrhea", "."], "h": {"id": "C0699744", "name": "C0699744#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [9, 10]}}
{"token": ["External", "C0699744#ent", "<e1>", "is", "characterized", "by", "C0004604#ent", "<e2>", ",", "otorrhea", ",", "itching", ",", "and", "hearing", "loss"], "h": {"id": "C0699744", "name": "C0699744#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [6, 7]}}
{"token": ["We", "have", "concluded", "that", "the", "potent", "inhibition", "of", "C1448313#ent", "<e1>", "by", "ebselen", "is", "due", "neither", "to", "C1260386#ent", "<e2>", "peroxidase-like", "activity", "to", "lowering", "of", "the", "hydroperoxide", "tone"], "h": {"id": "C1448313", "name": "C1448313#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [16, 17]}}
{"token": ["The", "phosphorylation", "of", "S54", "is", "controlled", "by", "the", "coordinated", "action", "of", "two", "cellular", "enzymes", "a", "lithium-sensitive", "kinase", ",", "probably", "C0017932#ent", "<e1>", "GSK-3", ")", "beta", "and", "protein", "phosphatase", "2A", "C1704708#ent", "<e2>", ")", "."], "h": {"id": "C0017932", "name": "C0017932#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [28, 29]}}
{"token": ["Using", "this", "in", "vitro", "retina", "and", "\"", "knock", "out", "\"", "of", "C4082696#ent", "<e1>", "expression", ",", "we", "could", "show", "a", "key", "role", "of", "C1412756#ent", "<e2>", "during", "neurogenesis", "."], "h": {"id": "C4082696", "name": "C4082696#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412756", "name": "C1412756#ent", "pos": [22, 23]}}
{"token": ["Heterozygous", "inactivating", "mutations", "of", "the", "C1706339#ent", "<e1>", "responsible", "for", "reduced", "activity", "of", "the", "alpha", "subunit", "the", "C1705766#ent", "<e2>", "G(Salpha", ")", ")", ",", "a", "protein", "that", "mediates", "hormone", "signal", "transduction", "across", "cell", "membranes"], "h": {"id": "C1706339", "name": "C1706339#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705766", "name": "C1705766#ent", "pos": [16, 17]}}
{"token": ["Two", "siRNAs", "(", "MDR1", ",", "C1412071#ent", "<e1>", ")", "which", "specifically", "targeted", "MDR1", "and", "C1412071#ent", "<e1>", "C0017337#ent", "<e1>", "were", "transferred", "into", "A2780/DDP", "cells", "."], "h": {"id": "C1412071", "name": "C1412071#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}}
{"token": ["Some", "of", "the", "mice", "in", "each", "group", "were", "injected", "C3273618#ent", "<e1>", "with", "adriamycin", "(", "C1412244#ent", "<e2>", ";", "15", "mg/kg", "body", "weight", "and", "killed", "after", "30", "hr", "."], "h": {"id": "C3273618", "name": "C3273618#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412244", "name": "C1412244#ent", "pos": [14, 15]}}
{"token": ["C0268579#ent", "<e1>", "may", "cause", "visual", "disturbances", "C0220994#ent", "<e2>", "may", "cause", "delayed", "coma", "."], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0220994", "name": "C0220994#ent", "pos": [6, 7]}}
{"token": ["C0166745#ent", "<e1>", "(", "dicyclic", "structure", ")", "was", "the", "most", "potent", "C1704716#ent", "<e2>", ",", "which", "effectively", "reduced", "azidothymidine-induced", "overexpression", "of", "NF-kappaBp65", "and", "caspase-3", "in", "mouse", "myocardium", "and", "brain", "cortex"], "h": {"id": "C0166745", "name": "C0166745#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704716", "name": "C1704716#ent", "pos": [10, 11]}}
{"token": ["These", "results", "identify", "a", "key", "role", "of", "PI3K", "signaling", "mediating", "the", "stress", "protocol-induced", "modification", "of", "hippocampal", "synaptic", "plasticity", "and", "further", "suggest", "that", "C1705590#ent", "<e1>", "do", "so", "by", "invoking", "the", "protein", "expression", "C1705335#ent", "<e2>", "."], "h": {"id": "C1705590", "name": "C1705590#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1705335", "name": "C1705335#ent", "pos": [31, 32]}}
{"token": ["Met", "and", "ron", "C0033713#ent", "<e1>", "encode", "the", "cell", "surface", "receptors", "hepatocyte", "growth", "factor", "C1524023#ent", "<e2>", ")", "and", "hepatocyte", "growth", "factor-like", "HLP", ")", "protein", ",", "respectively", ",", "and", "induce", "mitogenesis", ",", "motogenesis", ",", "morphogenesis", ",", "and", "metastatic", "activity", "various", "cell", "types"], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [13, 14]}}
{"token": ["The", "met", "C0033713#ent", "<e1>", "Met", ",", "is", "the", "tyrosine", "kinase", "growth", "factor", "receptor", "hepatocyte", "growth", "factor/scatter", "factor", "C1524023#ent", "<e2>", ")", "."], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [17, 18]}}
{"token": ["C1881373#ent", "<e1>", "(", "T(4", ")", ")", "nongenomically", "promotes", "association", "of", "C0752312#ent", "<e2>", "MAPK", ")", "and", "thyroid", "hormone", "receptor", "TRbeta1", "TR", ")", "in", "the", "cell", "nucleus", "leading", "to", "serine", "phosphorylation", "the", "receptor", "."], "h": {"id": "C1881373", "name": "C1881373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [10, 11]}}
{"token": ["Nucleotide", "sequence", "analysis", "the", "biosynthetic", "gene", "cluster", "C0017337#ent", "<e1>", "encoding", "two", "ketosynthases", ",", "a", "chain", "length", "factor", "an", "C0009228#ent", "<e2>", "three", "acetyl-CoA", "carboxylase", "subunits", "two", "cyclases", ",", "two", "oxygenases", ",", "an", "amidase", ",", "and", "remarkably", ",", "two", "acyl", "carrier", "proteins"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009228", "name": "C0009228#ent", "pos": [18, 19]}}
{"token": ["In", "a", "gene", "phylogeny", "zebrafish", "hoxb2", "clusters", "with", "human", "C1415665#ent", "<e1>", ",", "and", "it", "maps", "on", "linkage", "group", "along", "with", "several", "other", "loci", "whose", "orthologues", "are", "C1419895#ent", "<e2>", "with", "human", "C1415665#ent", "<e1>", "."], "h": {"id": "C1419895", "name": "C1419895#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1415665", "name": "C1415665#ent", "pos": [9, 10]}}
{"token": ["We", "propose", "that", "C1414438#ent", "<e1>", "may", "be", "useful", "in", "the", "treatment", "of", "C0010346#ent", "<e2>"], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [12, 13]}}
{"token": ["The", "experiment", "gave", "pronounced", "C0011991#ent", "<e1>", "100", "per", "cent", ")", "accoumpanied", "by", "C0011175#ent", "<e2>", ",", "weight", "loss", "rough", "hair", ",", "greyish", "discoloration", "the", "skin", ",", "and", "other", "manifestations", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0011175", "name": "C0011175#ent", "pos": [12, 13]}}
{"token": ["C0538927#ent", "<e1>", "is", "metabolized", "by", "C0608437#ent", "<e2>", "and", "may", "be", "increased", "or", "decreased", "by", "CYP2C9", "modifiers", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [5, 6]}}
{"token": ["This", "may", "be", "due", "to", "increased", "metabolism", "of", "C0538927#ent", "<e1>", "due", "to", "the", "induction", "of", "C0608437#ent", "<e2>", "CYP2C9", ")", "in", "liver", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [8, 9]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [15, 16]}}
{"token": ["Since", "C0538927#ent", "<e1>", "should", "be", "metabolized", "primarily", "by", "C0608437#ent", "<e2>", "CYP2C9", ")", ",", "a", "poor", "metabolizer", "PM", ")", "for", "this", "cytochrome", "P450", "enzyme", "included", "in", "the", "study", "."], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [1, 2]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [8, 9]}}
{"token": ["The", "group", "I", "II", "compounds", "C0040979#ent", "<e1>", "and", "prenylamine", ",", "did", "not", "affect", "the", "binding", "of", "C0028094#ent", "<e2>", "."], "h": {"id": "C0040979", "name": "C0040979#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "we", "investigate", "in", "detail", "the", "role", "of", "the", "Rho", "GTPases", ",", "C1366537#ent", "<e1>", ",", "Rac1", "and", "Rac2", "in", "C0031381#ent", "<e2>", "generation", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [20, 21]}}
{"token": ["C1333674#ent", "<e1>", "GHRH", ")", "and", "C1522428#ent", "<e2>", "(", "IL-1", ")", "are", "putative", "endogenous", "sleep-promoting", "substances", "."], "h": {"id": "C1333674", "name": "C1333674#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [5, 6]}}
{"token": ["The", "involvement", "of", "endogenous", "C1333674#ent", "<e1>", "GHRH", ")", "in", "the", "sleep-promoting", "activity", "of", "C1522428#ent", "<e2>", "(", "IL1", ")", "was", "studied", "."], "h": {"id": "C1333674", "name": "C1333674#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [13, 14]}}
{"token": ["32PO4-labeled", "lipomodulin", "was", "detected", "in", "the", "extract", "of", "23A4", "cells", "3", "to", "5", "min", "after", "the", "addition", "of", "C0120465#ent", "<e1>", ",", "bradykinin", ",", "or", "C0256103#ent", "<e2>", "."], "h": {"id": "C0120465", "name": "C0120465#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [24, 25]}}
{"token": ["C1412172#ent", "<e1>", ",", "a", "component", "of", "the", "C1412171#ent", "<e2>", "is", "a", "key", "regulator", "of", "actin", "polymerization", "co-localized", "with", "cortactin", "."], "h": {"id": "C1412172", "name": "C1412172#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412171", "name": "C1412171#ent", "pos": [7, 8]}}
{"token": ["The", "expression", "of", "VEGF", "and", "its", "receptors", "and", "the", "expression", "of", "cNOS", "and", "C1417760#ent", "<e1>", "were", "not", "altered", "in", "patients", "with", "C1504769#ent", "<e2>", "."], "h": {"id": "C1417760", "name": "C1417760#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [21, 22]}}
{"token": ["A", "45-year-old", "man", "developed", "a", "C0030193#ent", "<e1>", "and", "rapidly", "progressive", "sensory-motor", "polyneuropathy", "associated", "with", "confusion", "and", "C4048158#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [16, 17]}}
{"token": ["Otherwise", ",", "C0012634#ent", "<e1>", "occur", "during", "pregnancy", "share", "the", "characteristic", "of", "C0017178#ent", "<e2>", "that", "their", "manifestations", "are", "not", "clearly", "different", "from", "the", "nonpregnant", "state"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "fetal", "brown", "adipocytes", "lacking", "IGF-IR", "up-regulated", "C1421313#ent", "<e1>", "expression", "in", "the", "absence", "of", "insulin", "when", "C1335238#ent", "<e2>", ",", "but", "not", "C/EBPalpha", ",", "was", "overexpressed", "."], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [18, 19]}}
{"token": ["Total", "SOD", "activity", "in", "C0267797#ent", "<e1>", "AVH", ")", "and", "C2711227#ent", "<e2>", "FL", ")", "groups", "was", "significantly", "lower", "than", "that", "in", "non-specific", "reactive", "hepatitis", "NSRH", ")", "group", "."], "h": {"id": "C0267797", "name": "C0267797#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [9, 10]}}
{"token": ["C1417679#ent", "<e1>", "encoding", "the", "individual", "C1136365#ent", "<e2>", "perform", "the", "decarboxylation", "of", "malonate", "in", "K.", "pneumoniae", "M.", "rubra", "have", "been", "identified", "within", "the", "mdc", "and", "mad", "gene", "clusters", "respectively", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [5, 6]}}
{"token": ["We", "report", "the", "cases", "of", "two", "patients", "with", "C3536819#ent", "<e1>", "overdose", "in", "which", "the", "use", "of", "C0001275#ent", "<e2>", "was", "hampered", "by", "gastrointestinal", "abnormalities"], "h": {"id": "C3536819", "name": "C3536819#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001275", "name": "C0001275#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "the", "expression", "patterns", "of", "C1425348#ent", "<e1>", "and", "the", "C3494976#ent", "<e2>", "overlapped", "in", "atherosclerotic", "plaques"], "h": {"id": "C1425348", "name": "C1425348#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [10, 11]}}
{"token": ["The", "calmidazolium-induced", "increase", "in", "C0031671#ent", "<e1>", "activity", "was", "not", "affected", "by", "the", "protein", "kinase", "inhibitors", "H7", "and", "C0075193#ent", "<e2>", "."], "h": {"id": "C0031671", "name": "C0031671#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0075193", "name": "C0075193#ent", "pos": [17, 18]}}
{"token": ["The", "acidic", "COOH-terminal", "domain", "p115", "links", "the", "Golgins", ",", "Giantin", "on", "C1413605#ent", "<e1>", "vesicles", ",", "to", "C1415174#ent", "<e2>", "on", "Golgi", "membranes"], "h": {"id": "C1413605", "name": "C1413605#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415174", "name": "C1415174#ent", "pos": [16, 17]}}
{"token": ["Human", "DDX3", "(", "hDDX3", ")", "is", "a", "C0252684#ent", "<e1>", "to", "possess", "RNA-unwinding", "and", "C0001473#ent", "<e2>", "ATPase", ")", "activities", "."], "h": {"id": "C0252684", "name": "C0252684#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [13, 14]}}
{"token": ["Human", "DDX3", "(", "hDDX3", ")", "is", "a", "C0252684#ent", "<e1>", "to", "possess", "RNA-unwinding", "and", "adenosine", "triphosphatase", "C0001473#ent", "<e2>", ")", "activities", "."], "h": {"id": "C0252684", "name": "C0252684#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [15, 16]}}
{"token": ["Dopamine", "and", "SKF", "R-38393", "induced", "overexpression", "of", "the", "nitric-oxide", "synthase", "NOS", ")", "isoforms", "neuronal", "NOS", ",", "inducible", "NOS", "C0669372#ent", "<e1>", ")", ",", "and", "endothelial", "NOS", "a", "C0058980#ent", "<e2>", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [26, 27]}}
{"token": ["We", "report", "an", "unusual", "case", "of", "a", "male", "patient", "with", "a", "colovesical", "fistula", "secondary", "to", "C0012813#ent", "<e1>", "presenting", "in", "the", "genitourinary", "medicine", "clinic", "as", "C0018078#ent", "<e2>"], "h": {"id": "C0012813", "name": "C0012813#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018078", "name": "C0018078#ent", "pos": [24, 25]}}
{"token": ["Transglutaminases", "(", "TG", ")", ",", "which", "include", "C0015527#ent", "<e1>", "are", "calcium-dependent", "ubiquitous", "C3540772#ent", "<e2>", "."], "h": {"id": "C0015527", "name": "C0015527#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [12, 13]}}
{"token": ["The", "influences", "of", "C0243192#ent", "<e1>", "and", "antagonist", "of", "the", "transient", "receptor", "potential", "vanilloid", "4", "C1425291#ent", "<e2>", ")", "on", "the", "contractility", "of", "myocardium", "under", "hyposmotic", ",", "isosmotic", "and", "hyperosmotic", "conditions", "were", "observed", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425291", "name": "C1425291#ent", "pos": [14, 15]}}
{"token": ["We", "measured", "the", "maximal", "and", "minimal", "motor", "nerve", "conduction", "velocities", "of", "the", "ulnar", "nerve", "17", "patients", "with", "C0043116#ent", "<e1>", "SMA", ")", ",", "27", "patients", "with", "amyotrophic", "lateral", "sclerosis", "C1456383#ent", "<e2>", ")", ",", "and", "40", "age-matched", "control", "subjects"], "h": {"id": "C0043116", "name": "C0043116#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1456383", "name": "C1456383#ent", "pos": [28, 29]}}
{"token": ["Xerosis/acquired", "ichthyosis", "giant", "molluscum", "contagiosum", "characteristically", "seen", "in", "group", "IV", "HIV", "disease", "whereas", "C0006849#ent", "<e1>", "oral", "aphthae", "papular", "dermatitis", "HIV", ",", "and", "C0033860#ent", "<e2>", "were", "early", "warning", "signs"], "h": {"id": "C0006849", "name": "C0006849#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [22, 23]}}
{"token": ["To", "explore", "the", "levels", "of", "soluble", "TRAIL", "and", "C1705132#ent", "<e1>", "in", "plasma", "of", "patients", "with", "congestive", "heart", "failure", "C0018802#ent", "<e2>", ")", "and", "the", "effects", "of", "perindopril", "."], "h": {"id": "C1705132", "name": "C1705132#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [18, 19]}}
{"token": ["The", "effect", "of", "exercise", "in", "raising", "HDL", "cholesterol", "and", "the", "inverse", "relation", "between", "exercise", "and", "C0010068#ent", "<e1>", "may", "be", "partly", "the", "result", "of", "this", "C1951340#ent", "<e2>", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1951340", "name": "C1951340#ent", "pos": [24, 25]}}
{"token": ["We", "now", "studied", "the", "influence", "of", "imidazoline/guanidinium", "compounds", "such", "as", "clonidine", "and", "C0079466#ent", "<e1>", "on", "visceral", "pain", "the", "presence", "or", "absence", "of", "yohimbine", "and", "C0003143#ent", "<e2>", "."], "h": {"id": "C0079466", "name": "C0079466#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003143", "name": "C0003143#ent", "pos": [24, 25]}}
{"token": ["Vav", "proteins", "C0872913#ent", "<e1>", "and", "B-cell", "activation", "functioning", "as", "GTP/GDP", "exchange", "factors", "for", "C0751984#ent", "<e2>"], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [13, 14]}}
{"token": ["Whereas", "respiratory", "heme", "proteins", "located", "in", "mitochondria", ",", "C0056926#ent", "<e1>", "to", "the", "one", "described", "for", "the", "C3538760#ent", "<e2>", "be", "visualized", "in", "the", "cell", "membrane", "HepG2", "cells", "immunohistochemistry", "."], "h": {"id": "C0056926", "name": "C0056926#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3538760", "name": "C3538760#ent", "pos": [16, 17]}}
{"token": ["Increased", "C1568288#ent", "<e1>", "expression", "by", "C0256103#ent", "<e2>", "treatment", "was", "associated", "with", "increased", "activation", "of", "proMMP-2", "."], "h": {"id": "C1568288", "name": "C1568288#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [5, 6]}}
{"token": ["C0023529#ent", "<e1>", "seen", "most", "often", "in", "preterm", "infants", "basal", "ganglia", "hemorrhage", "C0014068#ent", "<e2>", "occurred", "in", "term", "infants", ",", "and", "focal", "parenchymal", "hemorrhage", "at", "all", "gestational", "ages"], "h": {"id": "C0023529", "name": "C0023529#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0014068", "name": "C0014068#ent", "pos": [11, 12]}}
{"token": ["Therefore", "different", "benzodiazepines", "(", "C0265326#ent", "<e1>", ")", ",", "namely", "diazepam", ",", "C0032910#ent", "<e2>", ",", "clonazepam", "and", "lorazepam", ",", "were", "incorporated", "into", "this", "emulsion", "formulation"], "h": {"id": "C0265326", "name": "C0265326#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032910", "name": "C0032910#ent", "pos": [11, 12]}}
{"token": ["Our", "study", "investigated", "two", "C0751956#ent", "<e1>", "patients", "with", "C0007758#ent", "<e2>", "lesions", "of", "the", "dorsal", "stream", "a", "delayed", "pointing", "task", "."], "h": {"id": "C0751956", "name": "C0751956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [8, 9]}}
{"token": ["Histologically", ",", "IgA", "nephropathy", "minimal", "change", "disease", "the", "main", "patterns", "among", "patients", "with", "primary", "glomerulonephritis", "C0744422#ent", "<e1>", "the", "commonest", "pattern", "among", "patients", "with", "C4053959#ent", "<e2>"], "h": {"id": "C0744422", "name": "C0744422#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [23, 24]}}
{"token": ["Our", "aim", "is", "to", "determine", "the", "influence", "of", "the", "C0004153#ent", "<e1>", "generalization", "upon", "C1337091#ent", "<e2>", "coronary", "heart", "disease", "with", "regard", "to", "ECG", "stress", "test"], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [13, 14]}}
{"token": ["A", "possible", "mechanism", "by", "which", "C.", "pneumoniae", "participate", "in", "the", "pathogenesis", "of", "C0004153#ent", "<e1>", "is", "through", "C1337091#ent", "<e2>", "the", "initiation", "of", "a", "chronic", "inflammatory", "state", "the", "infected", "arterial", "wall"], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [16, 17]}}
{"token": ["Two", "distinct", "structural", "genes", "Cat1", "and", "C3897681#ent", "<e1>", ")", "encoding", "the", "C0008169#ent", "<e2>", "CAT", ")", "are", "differentially", "expressed", "in", "this", "tissue", "during", "postgerminative", "development", "."], "h": {"id": "C3897681", "name": "C3897681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008169", "name": "C0008169#ent", "pos": [11, 12]}}
{"token": ["We", "fused", "the", "first", "171", "C3539947#ent", "<e1>", "huntingtin", ",", "containing", "either", "a", "pathogenic", "or", "normal", "C0392213#ent", "<e2>", "to", "the", "enhanced", "green", "fluorescent", "protein", "EGFP", ")", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0392213", "name": "C0392213#ent", "pos": [15, 16]}}
{"token": ["C3891563#ent", "<e1>", "expression", "was", "significantly", "associated", "with", ",", "whereas", "the", "C1439342#ent", "<e2>", "intensity", "of", "CD45RA", "tended", "to", "be", "associated", "with", "."], "h": {"id": "C3891563", "name": "C3891563#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1439342", "name": "C1439342#ent", "pos": [10, 11]}}
{"token": ["The", "purpose", "of", "this", "experiment", "was", "to", "assess", "the", "roles", "of", "free", ",", "intracellular", "calcium", "and", "C0006784#ent", "<e1>", "calpain", "II", "EC.34.22.17", ")", "in", "selenite", "C0392557#ent", "<e2>"], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0392557", "name": "C0392557#ent", "pos": [24, 25]}}
{"token": ["In", "the", "present", "study", ",", "a", "more", "in", "vivo-relevant", "model", "was", "generated", "to", "test", "the", "hypothesis", "that", "the", "C0006784#ent", "<e1>", "involved", "in", "age-related", "C0392557#ent", "<e2>", "alpha3Cx46", "knockout", "mice"], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0392557", "name": "C0392557#ent", "pos": [23, 24]}}
{"token": ["Mice", "were", "rendered", "monocytopenic", "by", "administration", "of", "etoposide", ",", "a", "C0013227#ent", "<e1>", "that", "selectively", "depletes", "the", "monocyte/macrophage", "population", "then", "injected", "with", "C4083008#ent", "<e2>", "(", "1", "x", "10(7", ")", "colony-forming", "units", "mouse", ")", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4083008", "name": "C4083008#ent", "pos": [21, 22]}}
{"token": ["No", "other", "hemodynamic", "effects", "of", "either", "bacteria", "or", "C0013227#ent", "<e1>", "were", "observed", "despite", "continued", "infusion", "of", "C4083008#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4083008", "name": "C4083008#ent", "pos": [16, 17]}}
{"token": ["C0031507#ent", "<e1>", "did", "not", "significantly", "alter", "CNS", "and", "C1424662#ent", "<e2>", "toxicity", "rates", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424662", "name": "C1424662#ent", "pos": [8, 9]}}
{"token": ["In", "10", "hypertensive", "patients", ",", "intravenous", "injection", "an", "angiotensin", "converting", "enzyme", "inhibitor", "C0136123#ent", "<e1>", ",", "immediately", "re-established", "the", "C0042402#ent", "<e2>", "these", "two", "stimuli", "."], "h": {"id": "C0136123", "name": "C0136123#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [18, 19]}}
{"token": ["However", ",", "human", "CMV-encoded", "C1423033#ent", "<e1>", "counteracts", "surface", "expression", "of", "several", "C3540617#ent", "<e2>", "intracellular", "retention", "."], "h": {"id": "C1423033", "name": "C1423033#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3540617", "name": "C3540617#ent", "pos": [11, 12]}}
{"token": ["C1705269#ent", "<e1>", "stimulates", "eIF4E-dependent", "export", "of", "cyclin", "D1", "ornithine", "decarboxylase", "C1417932#ent", "<e2>", ")", "mRNAs", "in", "the", "nucleus", ",", "as", "well", "as", "increases", "the", "translation", "efficiency", "of", "C1417932#ent", "<e2>", "mRNA", "in", "the", "cytoplasm", "."], "h": {"id": "C1705269", "name": "C1705269#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [10, 11]}}
{"token": ["In", "mouse", "fibroblasts", "deficient", "in", "either", "Rce1", "(", "Ras", "converting", "enzyme", "1", ")", "or", "Icmt", "(", "isoprenylcysteine", "carboxyl", "methyltransferase", ",", "C1415714#ent", "<e1>", "was", "mislocalized", "mainly", "to", "the", "Golgi", "apparatus", "whereas", "C1419383#ent", "<e2>", "showed", "diffuse", "localization"], "h": {"id": "C1415714", "name": "C1415714#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1419383", "name": "C1419383#ent", "pos": [30, 31]}}
{"token": ["Various", "agonists", ",", "pathological", "conditions", "and", "therapeutic", "interventions", "to", "modulated", "expression", "and", "function", "of", "oxidant", "and", "antioxidant", "enzymes", "including", "NAD(P)H", "oxidase", "endothelial", "nitric", "oxide", "synthase", "C1421531#ent", "<e1>", "myeloperoxidase", ",", "superoxide", "dismutases", "catalase", ",", "C0914833#ent", "<e2>", "and", "glutathione", "peroxidase"], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0914833", "name": "C0914833#ent", "pos": [33, 34]}}
{"token": ["Clinical", "presentation", "STEMI", ",", "is", "different", "than", "the", "other", "C0151744#ent", "<e1>", "the", "sudden", "onset", "the", "duration", "and", "the", "severity", "of", "chest", "pain", "C2364135#ent", "<e2>", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [22, 23]}}
{"token": ["C0010762#ent", "<e1>", "rabbits", "metabolized", "C1414134#ent", "<e2>", "compounds", "to", "form", "cytochrome", "P-450-metabolite", "P-450-MI", ")", "complexes", "as", "indicated", "by", "difference", "spectra", "in", "the", "Soret", "region", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414134", "name": "C1414134#ent", "pos": [4, 5]}}
{"token": ["To", "evaluate", "the", "prevalence", "and", "the", "characteristics", "of", "diabetic", "retinopathy", "thalassaemics", "we", "examined", "46", "patients", "with", "C4274391#ent", "<e1>", "major", "and", "C0011860#ent", "<e2>", "fluorescein", "angiography"], "h": {"id": "C4274391", "name": "C4274391#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [20, 21]}}
{"token": ["Collectively", ",", "we", "define", "GSKIP", "as", "a", "naturally", "occurring", "protein", "that", "is", "C1512488#ent", "<e1>", "with", "the", "C0244988#ent", "<e2>", "interaction", "domain", "Axin", "and", "is", "able", "to", "negatively", "regulate", "C0244988#ent", "<e2>", "of", "the", "Wnt", "signaling", "pathway"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [16, 17]}}
{"token": ["Likewise", ",", "antinociception", "induced", "by", "the", "kappa-opioid", "agonist", "C0147448#ent", "<e1>", "was", "unaltered", "in", "animals", "pretreated", "with", "SCH", "23390", "increased", "by", "C0038803#ent", "<e2>", ",", "and", "reduced", "by", "SKF", "38393", "."], "h": {"id": "C0147448", "name": "C0147448#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038803", "name": "C0038803#ent", "pos": [20, 21]}}
{"token": ["In", "Zymomonas", "mobilis", "the", "genes", "encoding", "glyceraldehyde-3-phosphate", "dehydrogenase", "GAP", ")", "and", "C1418508#ent", "<e1>", "PGK", ")", "are", "encoded", "in", "an", "C0022895#ent", "<e2>", "that", "is", "transcribed", "from", "tandem", "promoters"], "h": {"id": "C1418508", "name": "C1418508#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [19, 20]}}
{"token": ["The", "target", "of", "this", "study", "is", "to", "evaluate", "the", "clinical", "significance", "C1418724#ent", "<e1>", "C1415311#ent", "<e2>", "the", "potential", "of", "small", "interfering", "RNA-induced", "genetic", "silencing", "C1418724#ent", "<e1>", "C1415311#ent", "<e2>", "a", "supplementary", "therapeutic", "way", "for", "laryngeal", "squamous", "cell", "carcinoma"], "h": {"id": "C1418724", "name": "C1418724#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415311", "name": "C1415311#ent", "pos": [13, 14]}}
{"token": ["Substitution", "of", "threonine", "by", "serine", "residues", "in", "this", "C0030956#ent", "<e1>", "also", "yields", "a", "glycosylated", "fusion", "protein", "is", "modified", "with", "C0001056#ent", "<e2>", "but", "not", "all", "of", "the", "serines", "are", "glycosylated", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001056", "name": "C0001056#ent", "pos": [19, 20]}}
{"token": ["LDH", "levels", "in", "XX", "and", "C1704669#ent", "<e1>", "oocytes", "were", "equal", ",", "whereas", "STS", "and", "C1333652#ent", "<e2>", "levels", "were", "approximately", "twice", "as", "high", "in", "XX", "oocytes", "as", "in", "C1704669#ent", "<e1>", "oocytes", "."], "h": {"id": "C1704669", "name": "C1704669#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333652", "name": "C1333652#ent", "pos": [14, 15]}}
{"token": ["In", "a", "randomized", "trial", "patients", "with", "C0011881#ent", "<e1>", "we", "found", "that", "C0014025#ent", "<e2>", "treatment", "reduced", "proteinuria", "to", "less", "than", "half", "the", "level", "obtained", "in", "a", "metoprolol-treated", "group", "during", "equally", "effective", "blood", "pressure", "control"], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [11, 12]}}
{"token": ["Of", "16", "patients", "with", "C0011881#ent", "<e1>", "6", "served", "as", "control", "and", "10", "received", "C0014025#ent", "<e2>", "."], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "C1541381#ent", "<e1>", "decreased", "the", "level", "of", "C0812246#ent", "<e2>", "in", "endotoxaemic", "animals", "."], "h": {"id": "C1541381", "name": "C1541381#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [9, 10]}}
{"token": ["In", "E14", "kidneys", "C1528301#ent", "<e1>", "below", "detection", "level", ",", "whereas", "at", "day", "C3811108#ent", "<e2>", ",", "ureteric", "buds", "s-shaped", "bodies", "outgrowing", "loops", "of", "Henle", "expressed", "detectable", "amounts", "of", "C1528301#ent", "<e1>"], "h": {"id": "C1528301", "name": "C1528301#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811108", "name": "C3811108#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "the", "impact", "of", "Rheolytic", "thrombectomy", "RT", ")", "on", "the", "clinical", "and", "angiographic", "outcome", "of", "patients", "with", "C4255010#ent", "<e1>", "STEMI", ")", "and", "large", "thrombus", "burden", "C0812309#ent", "<e2>", ")", "."], "h": {"id": "C4255010", "name": "C4255010#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0812309", "name": "C0812309#ent", "pos": [26, 27]}}
{"token": ["Capillary", "isotachophoresis", "was", "applied", "for", "the", "determination", "of", "C0015824#ent", "<e1>", "and", "gallopamil", "--", "C0006684#ent", "<e2>", "in", "serum", "."], "h": {"id": "C0015824", "name": "C0015824#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [13, 14]}}
{"token": ["These", "results", "clearly", "differentiate", "bepridil", "and", "C0015824#ent", "<e1>", "from", "the", "other", "C0006684#ent", "<e2>", "."], "h": {"id": "C0015824", "name": "C0015824#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [11, 12]}}
{"token": ["C0008354#ent", "<e1>", "cause", "conjunctivitis", ",", "wound", "infection", "C0017160#ent", "<e2>", "and", "serious", "sepsis", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017160", "name": "C0017160#ent", "pos": [7, 8]}}
{"token": ["PAK1", "is", "a", "C0010536#ent", "<e1>", "of", "the", "C0751984#ent", "<e2>", "Rac", "and", "Cdc42", "that", "previous", "work", "has", "implicated", "in", "endothelial", "cell", "migration", "modulation", "of", "cell", "contraction"], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [7, 8]}}
{"token": ["The", "molecular", "features", "the", "best", "activities", "are", "the", "2-(diethylamino)ethylenediamine", "group", "at", "the", "5-position", "of", "the", "C0013085#ent", "<e1>", "an", "oxepin", "skeleton", "than", "a", "C0013065#ent", "<e2>", "or", "a", "pyran", "skeleton"], "h": {"id": "C0013085", "name": "C0013085#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013065", "name": "C0013065#ent", "pos": [22, 23]}}
{"token": ["To", "test", "the", "associations", "between", "the", "N363S", "polymorphism", "of", "the", "glucocorticoid", "receptor", "gene", "C1705401#ent", "<e1>", ")", "and", "factors", "related", "to", "the", "C0524620#ent", "<e2>", "middle-aged", "men", "with", "and", "without", "juvenile-onset", "obesity", "."], "h": {"id": "C1705401", "name": "C1705401#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [21, 22]}}
{"token": ["Gamma-glutamyl", "transpeptidase", "GGT", ")", "is", "a", "widely", "distributed", "C1947941#ent", "<e1>", "responsible", "for", "the", "degradation", "of", "glutathione", "in", "the", "C1415051#ent", "<e2>"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415051", "name": "C1415051#ent", "pos": [18, 19]}}
{"token": ["Both", "C0030956#ent", "<e1>", "influence", "the", "C0036755#ent", "<e2>", "melatonin", "synthesis", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036755", "name": "C0036755#ent", "pos": [5, 6]}}
{"token": ["Here", "we", "present", "a", "case", "of", "reactive", "hemophagocytosis", "associated", "with", "initiation", "of", "highly", "active", "antiretroviral", "therapy", "(", "HAART", ")", ",", "probably", "representing", "a", "C1848862#ent", "<e1>", "termed", "the", "immune", "reconstitution", "inflammatory", "syndrome", "C1256254#ent", "<e2>", ")", "or", "immune", "reconstitution", "syndrome"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1256254", "name": "C1256254#ent", "pos": [31, 32]}}
{"token": ["The", "immunoassay", "was", "based", "on", "an", "indirect", "competitive", "immunoreaction", "of", "an", "alkaline", "phosphatase", "C1706468#ent", "<e1>", ")", "labeled", "anti-Vg", "monoclonal", "antibody", "the", "fraction", "of", "Vg", "C2350558#ent", "<e2>", "on", "the", "magnetic", "beads", "Vg", "in", "the", "sample", "solution"], "h": {"id": "C1706468", "name": "C1706468#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [24, 25]}}
{"token": ["Information", "collected", "in", "this", "study", "will", "assist", "in", "the", "assessment", "of", "the", "potential", "value", "of", "HMG", "Co-A", "reductase", "inhibitors", "C0360714#ent", "<e1>", ")", "in", "reducing", "the", "risk", "of", "C0242383#ent", "<e2>", "progression", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [27, 28]}}
{"token": ["Histologically", ",", "P", "haemolytica", "caused", "C0740766#ent", "<e1>", "necrosis", "of", "the", "lung", "parenchyma", "C0264538#ent", "<e2>", "RSV", "alone", "caused", "interstitial", "pneumonitis", "bronchiolitis", ",", "and", "hemorrhage", "."], "h": {"id": "C0740766", "name": "C0740766#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0264538", "name": "C0264538#ent", "pos": [12, 13]}}
{"token": ["C0149931#ent", "<e1>", "associated", "with", "disease", "activity", "antiphospholipid", "antibodies", "worsening", "of", "C0034734#ent", "<e2>", "phenomenon", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034734", "name": "C0034734#ent", "pos": [10, 11]}}
{"token": ["We", "demonstrated", "that", "sensitized", "spermatozoa", "exhibit", "the", "C0040822#ent", "<e1>", "phenomenon", "after", "contact", "with", "the", "C0072522#ent", "<e2>", "the", "cervical", "mucus", "not", "after", "contact", "with", "the", "aqueous", "fraction", "."], "h": {"id": "C0040822", "name": "C0040822#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [14, 15]}}
{"token": ["To", "assess", "the", "efficacy", "of", "tetracycline", "in", "C0040866#ent", "<e1>", "ointment", "compared", "with", "triamcinolone", "acetonide", "ointment", "patients", "with", "moderate", "to", "severe", "C0011615#ent", "<e2>"], "h": {"id": "C0040866", "name": "C0040866#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [20, 21]}}
{"token": ["The", "staining", "intensity", "of", "the", "neuropil", "also", "increased", "in", "the", "trigeminal", "sensory", "nuclei", "to", "the", "neurotomy", "excepting", "laminae", "I", "C3273406#ent", "<e1>", "of", "the", "C4085195#ent", "<e2>", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4085195", "name": "C4085195#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggests", "a", "role", "for", "C0017860#ent", "<e1>", "in", "modulating", "the", "production", "of", "C0127400#ent", "<e2>", "inflammation", "."], "h": {"id": "C0017860", "name": "C0017860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [13, 14]}}
{"token": ["Phalloidin", "staining", "that", "activated", "C0244404#ent", "<e1>", "perturbed", "the", "C1333200#ent", "<e2>", "cell", "shape", "changes", "during", "pupal", "development", "."], "h": {"id": "C0244404", "name": "C0244404#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333200", "name": "C1333200#ent", "pos": [8, 9]}}
{"token": ["The", "active", "drugs", "in", "the", "study", "are", "actinomycin", "D", "C0026254#ent", "<e1>", "doxorubicin", ",", "4-[bis(2-chloroethyl)amino]aniline", "and", "C0008163#ent", "<e2>", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008163", "name": "C0008163#ent", "pos": [15, 16]}}
{"token": ["C0026254#ent", "<e1>", "busulphan", ",", "vincristine", ",", "C0008163#ent", "<e2>", ",", "cytosine", "arabinoside", "cyclophosphamide", "and", "lycurim", "were", "tested", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008163", "name": "C0008163#ent", "pos": [6, 7]}}
{"token": ["Inhibition", "of", "the", "upstream", "ERK1,2", "activator", "MEK1,2", "with", "C0755562#ent", "<e1>", "prevented", "IL-1beta-stimulated", "C0669372#ent", "<e2>", "expression", ",", "while", "the", "p38MAPK", "inhibitor", "potentiated", "C0669372#ent", "<e2>", "expression", "."], "h": {"id": "C0755562", "name": "C0755562#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}}
{"token": ["We", "observed", "35", "attacks", "of", "C0030305#ent", "<e1>", "23", "of", "1001", "patients", "with", "C2316810#ent", "<e2>", "and", "one", "additional", "patient", "with", "irreversible", "acute", "renal", "failure", "during", "a", "ten-year", "period", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [12, 13]}}
{"token": ["Often", ",", "rapid", "activation", "of", "intracellular", "signallers", "such", "as", "C0170168#ent", "<e1>", "MAPK", ")", "or", "C2936824#ent", "<e2>", "PI3K", "underlie", "alternative", "estrogen-induced", "neuroprotection", "upon", "activation", "of", "specific", "binding", "sites", "the", "plasma", "membrane"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [14, 15]}}
{"token": ["MSNA", "and", "heart", "rate", "to", "C1840333#ent", "<e1>", "were", "not", "different", "between", "the", "C0059036#ent", "<e2>", "and", "ML", "phases", ",", "but", "MAP", "responses", "to", "C1840333#ent", "<e1>", "were", "augmented", "during", "the", "ML", "phase", "P", "<", "0.03", ")", "."], "h": {"id": "C0059036", "name": "C0059036#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1840333", "name": "C1840333#ent", "pos": [5, 6]}}
{"token": ["Recent", "epidemiologic", "investigation", "demonstrated", "that", "malaria", ",", "amebiasis", ",", "C0041230#ent", "<e1>", ",", "leishmaniasis", "and", "C0338437#ent", "<e2>", "seemed", "important", "as", "judged", "from", "the", "number", "of", "infected", "individuals", ",", "primarily", "Japanese", "travellers", "."], "h": {"id": "C0041230", "name": "C0041230#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0338437", "name": "C0338437#ent", "pos": [14, 15]}}
{"token": ["The", "Boat-ataxin-1", "interaction", "is", "mediated", "through", "multiple", "regions", "both", "C0086376#ent", "<e1>", ",", "including", "a", "newly", "identified", "C1842690#ent", "<e2>", "(", "N-terminal", "region", "of", "Boat", "and", "ataxin-1", ")", "domain", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1842690", "name": "C1842690#ent", "pos": [16, 17]}}
{"token": ["The", "C0403529#ent", "<e1>", ",", "but", "the", "C0035086#ent", "<e2>", "to", "end-stage", "renal", "disease"], "h": {"id": "C0403529", "name": "C0403529#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [6, 7]}}
{"token": ["The", "C0755562#ent", "<e1>", "microinjection", "also", "attenuated", "C0751214#ent", "<e2>", "the", "ipsilateral", "hindpaw", "at", "24", "h", "after", "CFA", "injection", "."], "h": {"id": "C0755562", "name": "C0755562#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0751214", "name": "C0751214#ent", "pos": [6, 7]}}
{"token": ["A", "double-blind", "study", "carried", "out", "on", "20", "children", "with", "spasticity", "secondary", "to", "C0007789#ent", "<e1>", "in", "order", "to", "compare", "the", "effects", "of", "C0010977#ent", "<e2>", "and", "a", "placebo", "."], "h": {"id": "C0007789", "name": "C0007789#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0010977", "name": "C0010977#ent", "pos": [21, 22]}}
{"token": ["The", "neuromuscular", "diseases", "of", "8", "with", "C0026769#ent", "<e1>", "9", "with", "amyotrophic", "lateral", "sclerosis", "8", "with", "Steinert's", "disease", "11", "C0026848#ent", "<e2>", ",", "and", "10", "suffering", "from", "miscellaneous", "neurological", "diseases"], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "some", "components", "of", "C1333356#ent", "<e1>", "are", "associated", "with", "hereditary", "human", "syndromes", "xeroderma", "pigmentosum", "XP", ")", ",", "C0009207#ent", "<e2>", "CS", ")", "and", "trichothiodystrophy", "(", "TTD", ")", "."], "h": {"id": "C1333356", "name": "C1333356#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [18, 19]}}
{"token": ["Permanent", "consequences", "of", "transient", "synovitis", "of", "the", "C3538851#ent", "<e1>", "as", "elongation", "of", "the", "extremity", "and", "C1860826#ent", "<e2>", "X-ray", "pictures", "are", "rarely", "observed", "."], "h": {"id": "C3538851", "name": "C3538851#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1860826", "name": "C1860826#ent", "pos": [15, 16]}}
{"token": ["Human", "UDP-Gal", "transporter", "1", "C3538712#ent", "<e1>", ")", "and", "the", "human", "CMP-Sia", "transporter", "C1424670#ent", "<e2>", ")", "are", "similar", "in", "structure", ",", "with", "amino", "acid", "sequences", "are", "43", "%", "identical", ",", "but", "they", "have", "quite", "distinct", "transport", "substrates", "."], "h": {"id": "C3538712", "name": "C3538712#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424670", "name": "C1424670#ent", "pos": [12, 13]}}
{"token": ["Additional", "replacement", "of", "helix", "2", "3", "of", "C3538712#ent", "<e1>", "with", "the", "corresponding", "C1424670#ent", "<e2>", "sequence", "markedly", "increased", "the", "efficiency", "of", "CMP-Sia", "transport", "."], "h": {"id": "C3538712", "name": "C3538712#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1424670", "name": "C1424670#ent", "pos": [12, 13]}}
{"token": ["Comparisons", "of", "these", "C1417679#ent", "<e1>", "show", "the", "ZFY-like", "and", "C1824015#ent", "<e2>", "sequences", "to", "be", "strongly", "conserved", "across", "marsupials", ",", "birds", ",", "and", "lepidosaurians", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1824015", "name": "C1824015#ent", "pos": [9, 10]}}
{"token": ["The", "C0039238#ent", "<e1>", "involves", "the", "left", "atrium", "LA", ")", "and", "the", "pulmonary", "veins", "C1419141#ent", "<e2>", ")", "after", "atrial", "fibrillation", "AF", ")", "ablation", "has", "not", "been", "described", "."], "h": {"id": "C0039238", "name": "C0039238#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419141", "name": "C1419141#ent", "pos": [13, 14]}}
{"token": ["The", "US", "Food", "and", "Drug", "Administration", "a", "warning", "for", "all", "atypical", "C0040615#ent", "<e1>", "as", "a", "result", "of", "a", "meta-analysis", "of", "17", "placebo-controlled", "clinical", "trials", "various", "atypical", "C0040615#ent", "<e1>", "for", "the", "treatment", "of", "C3273505#ent", "<e1>", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3273505", "name": "C3273505#ent", "pos": [32, 33]}}
{"token": ["Analysis", "of", "blood", "and", "urine", "by", "TLC", "revealed", "that", "the", "rabbit", "more", "rapidly", "C0025517#ent", "<e1>", "both", "acetyl-INH", "to", "C0050523#ent", "<e2>", ",", "and", "C0050523#ent", "<e2>", "to", "diacetylhydrazine", "than", "did", "the", "rat", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0050523", "name": "C0050523#ent", "pos": [18, 19]}}
{"token": ["Activity", "in", "TBH", "M", "phi", "supernatants", "was", "found", "primarily", "in", "fractions", "eluting", "from", "hydroxylapatite", "at", "0.3", "M", "C3256935#ent", "<e1>", "pH", "7.3", ",", "was", "resistant", "to", "C0030940#ent", "<e2>", "but", "was", "sensitive", "to", "neuraminidase", "."], "h": {"id": "C3256935", "name": "C3256935#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [25, 26]}}
{"token": ["The", "physical", "map", "C0019163#ent", "<e1>", "DNA", "established", "for", "13", "C0012906#ent", "<e2>", "to", "conclude", "that", "the", "cloned", "DNA", "similar", ",", "but", "not", "identical", "to", "the", "C0019163#ent", "<e1>", "DNA", "of", "ayw", "subtype", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [9, 10]}}
{"token": ["By", "using", "prototype", "C0019163#ent", "<e1>", "of", "known", "subtype", "as", "a", "model", ",", "these", "C0012906#ent", "<e2>", "maps", "of", "the", "PCR", "product", "were", "subtype", "specific", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [13, 14]}}
{"token": ["When", "the", "radioactively", "labelled", "C0019163#ent", "<e1>", "DNA-protein", "complex", "digested", "with", "C0012906#ent", "<e2>", "Hind", "II", "subjected", "to", "polyacrylamide", "gel", "electrophoresis", "some", "radioactivity", "did", "not", "enter", "the", "gel", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [10, 11]}}
{"token": ["3-fold", ")", ",", "although", "Mg2", "+", "on", "its", "own", "had", "no", "effect", "on", "the", "interactions", "of", "either", "C3273649#ent", "<e1>", "or", "CheY", "with", "C3540471#ent", "<e2>", "-", "233", "."], "h": {"id": "C3273649", "name": "C3273649#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3540471", "name": "C3540471#ent", "pos": [22, 23]}}
{"token": ["Since", "phosphorylase", "a", "is", "a", "strong", "inhibitor", "of", "C0017933#ent", "<e1>", "its", "disappearance", "allows", "the", "activation", "of", "C0017932#ent", "<e2>", "the", "initiation", "of", "glycogen", "synthesis"], "h": {"id": "C0017933", "name": "C0017933#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [16, 17]}}
{"token": ["Treatment", "with", "C0028094#ent", "<e1>", "did", "not", "have", "a", "neuroprotective", "effect", "C0101767#ent", "<e2>", "animals", "in", "either", "behavioral", "or", "histological", "results", "."], "h": {"id": "C0028094", "name": "C0028094#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0101767", "name": "C0101767#ent", "pos": [10, 11]}}
{"token": ["The", "SIPC", "is", "a", "glycoprotein", "of", "high", "molecular", "mass", "consisting", "of", "three", "major", "C0599220#ent", "<e1>", "of", "76", ",", "88", "and", "98", "kDa", "with", "lentil", "lectin", "C0242209#ent", "<e2>"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242209", "name": "C0242209#ent", "pos": [25, 26]}}
{"token": ["The", "anaesthetics", "used", "were", "methohexitone", "sodium", "C0039925#ent", "<e1>", ",", "ICI", "35", "868", "(", "propofol", ",", "C0678120#ent", "<e2>", ")", ",", "althesin", "and", "etomidate", "."], "h": {"id": "C0039925", "name": "C0039925#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0678120", "name": "C0678120#ent", "pos": [15, 16]}}
{"token": ["Surgery", "for", "C0854119#ent", "<e1>", "used", "to", "estimate", "the", "infective", "dose", "aerobic", "and", "anaerobic", "bacteria", "postoperative", "C0036690#ent", "<e2>"], "h": {"id": "C0854119", "name": "C0854119#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [15, 16]}}
{"token": ["The", "severity", "of", "C0014179#ent", "<e1>", "influenced", "the", "percentage", "of", "cows", "pregnant", "at", "200", "C1414174#ent", "<e2>", "."], "h": {"id": "C0014179", "name": "C0014179#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414174", "name": "C1414174#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "we", "conclude", "that", "cleavage", "of", "the", "COOH-terminal", "lysine", "MMt", "by", "C1413673#ent", "<e1>", "two", "additional", "MM", "C0597298#ent", "<e2>", "prolonged", "plasma", "clearance", "rates"], "h": {"id": "C1413673", "name": "C1413673#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [17, 18]}}
{"token": ["C2350558#ent", "<e1>", "helical", "constructs", "derived", "from", "the", "C1412999#ent", "<e2>", "from", "HIV-1", "and", "HIV-2", "bound", "biotinylated", "recombinant", "CD4", "with", "Kd", "values", "of", "8.59", "nM", "and", "14.59", "nM", ",", "respectively", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [7, 8]}}
{"token": ["Staff", "have", "found", "that", "the", "stress", "of", "doing", "C0030193#ent", "<e1>", "children", "is", "reduced", "when", "C0022614#ent", "<e2>", "is", "used", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [14, 15]}}
{"token": ["This", "review", "restricts", "its", "focus", "to", "antivirals", "that", "may", "be", "used", "by", "dental", "practitioners", "principally", "those", "C0035064#ent", "<e1>", "active", "in", "C0019372#ent", "<e2>"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0019372", "name": "C0019372#ent", "pos": [20, 21]}}
{"token": ["The", "afimbrial", "AfaE-VIII", "adhesin", "is", "common", "among", "Escherichia", "coli", "isolates", "from", "calves", "with", "intestinal", "and/or", "C4082764#ent", "<e1>", "from", "humans", "with", "C0243026#ent", "<e2>", "or", "pyelonephritis", "."], "h": {"id": "C4082764", "name": "C4082764#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [20, 21]}}
{"token": ["Pyramidal", "tract", "signs", ",", "pale", "discs", "and", "C0011168#ent", "<e1>", "were", "more", "frequent", "in", "SCA1", "compared", "with", "SCA2", "and", "C0024408#ent", "<e2>", "patients", ",", "while", "double", "vision", "less", "frequently", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0024408", "name": "C0024408#ent", "pos": [18, 19]}}
{"token": ["The", "hepatic", "expression", "mRNAs", "hybridizable", "with", "cDNAs", "for", "UDP-glucuronosyltransferase", "1*6", "C1420459#ent", "<e1>", "glutathione", "S-transferase", "1", "carboxyesterase", "and", "C1134446#ent", "<e2>", "the", "Suncus", "were", "observed", "."], "h": {"id": "C1420459", "name": "C1420459#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [17, 18]}}
{"token": ["The", "mRNA", "levels", "of", "ACTB", ",", "GAPDH", ",", "GUSB", ",", "C1418793#ent", "<e1>", ",", "TBP", ",", "and", "C1420708#ent", "<e2>", "relative", "to", "HPRT1", "in", "human", "hepatocytes", "were", "constant", "at", "all", "concentrations", "of", "inducers", "."], "h": {"id": "C1418793", "name": "C1418793#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "two", "SF", "alpha-chain", "peptides", "(", "NK1", "and", "C1705924#ent", "<e1>", ")", "both", "bound", "to", "TSP-1", "and", "C1706331#ent", "<e2>", ",", "suggesting", "that", "the", "whole", "SF", "molecule", "is", "not", "required", "for", "binding", "."], "h": {"id": "C1705924", "name": "C1705924#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [17, 18]}}
{"token": ["Formoterol", "is", "effective", "in", "preventing", "C0004099#ent", "<e1>", "adults", "and", "children", "and", "confers", "significantly", "more", "protection", "than", "C0543495#ent", "<e2>", "when", "administered", "3", "and", "12", "hours", "before", "exercise", "."], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [16, 17]}}
{"token": ["It", "is", "unknown", "whether", "the", "angiotensin", "receptor", "antagonist", "C0216784#ent", "<e1>", "exerts", "a", "renoprotective", "effect", "patients", "with", "type", "2", "diabetes", "C0011881#ent", "<e2>", "independent", "of", "its", "hypotensive", "effects", "."], "h": {"id": "C0216784", "name": "C0216784#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "that", "C0216784#ent", "<e1>", "and", "enalapril", "have", "renoprotective", "effects", "C0011881#ent", "<e2>"], "h": {"id": "C0216784", "name": "C0216784#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [10, 11]}}
{"token": ["The", "relation", "between", "these", "C0001044#ent", "<e1>", "chemical", "compartments", "the", "distribution", "of", "preserved", "C0023783#ent", "<e2>", "neurons", "remained", "intact", ";", "NADPH-d", "neurons", "were", "predominantly", "observed", "in", "the", "matrix", "zone"], "h": {"id": "C0001044", "name": "C0001044#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023783", "name": "C0023783#ent", "pos": [12, 13]}}
{"token": ["Objective", ":", "Animal", "and", "in", "vivo", "human", "studies", "have", "observed", "that", "C0011847#ent", "<e1>", "alters", "the", "expression", "of", "hepatic", "metabolizing", "cytochrome", "P450", "CYP", ")", "and", "glutathione", "S-transferase", "(GST)", "C3540790#ent", "<e2>", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [27, 28]}}
{"token": ["This", "syndrome", "is", "related", "to", "a", "mutation", "of", "C1705397#ent", "<e1>", "located", "on", "chromosome", "7p13", "and", "its", "inheritance", "is", "C2936739#ent", "<e2>"], "h": {"id": "C1705397", "name": "C1705397#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [18, 19]}}
{"token": ["These", "data", "implicate", "mutations", "in", "C1705397#ent", "<e1>", "as", "the", "cause", "of", "C2936739#ent", "<e2>", "PHS", ",", "and", "suggest", "that", "frameshift", "mutations", "the", "C1705397#ent", "<e1>", "transcription", "factor", "gene", "alter", "the", "development", "of", "multiple", "organ", "systems", "in", "vertebrates", "."], "h": {"id": "C1705397", "name": "C1705397#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936739", "name": "C2936739#ent", "pos": [11, 12]}}
{"token": ["None", "of", "these", "sequence", "variations", "cosegregated", "with", "C3899988#ent", "<e1>", "ar", ")", "transmitted", "C1837790#ent", "<e2>", "in", "11", "breeds", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1837790", "name": "C1837790#ent", "pos": [12, 13]}}
{"token": ["C3538744#ent", "<e1>", "also", "rendered", "resistance", "to", "adefovir", "dipivoxil", "bis-POM-PMEA", ")", "and", "C0025677#ent", "<e2>", ",", "two", "reported", "C3538744#ent", "<e1>", "substrates", "."], "h": {"id": "C3538744", "name": "C3538744#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [11, 12]}}
{"token": ["Both", "clones", "express", "the", "endothelial", "markers", "C1332729#ent", "<e1>", "vascular", "intercellular", "adhesion", "molecule-1", "but", "do", "not", "express", "C1706508#ent", "<e2>", "and", "E-selectin", "."], "h": {"id": "C1332729", "name": "C1332729#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706508", "name": "C1706508#ent", "pos": [16, 17]}}
{"token": ["In", "adipose", "tissue", "segments", "obtained", "from", "patients", "with", "untreated", "C1832544#ent", "<e1>", "IGF-I", "and", "insulin", "inhibited", "C0017868#ent", "<e2>", "release", "in", "a", "normal", "way", "."], "h": {"id": "C1832544", "name": "C1832544#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "pharmaceutical", "development", "renal", "kallikrein", "releasers", ",", "such", "as", "K(ATP", ")", "channel", "blockers", ",", "and", "C3537035#ent", "<e1>", "such", "as", "C0058897#ent", "<e2>", "may", "lead", "to", "the", "development", "of", "novel", "antihypertensive", "drugs"], "h": {"id": "C3537035", "name": "C3537035#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0058897", "name": "C0058897#ent", "pos": [20, 21]}}
{"token": ["This", "review", "demonstrates", "genetic", "and", "phenotypic", "heterogeneity", "in", "all", "of", "the", "C0553604#ent", "<e1>", "called", "'", "myotonic", "dystrophies", "according", "to", "the", "new", "nomenclature", ":", "C2931689#ent", "<e2>", "myotonic", "dystrophy", "type", "2", "proximal", "myotonic", "myopathy", "proximal", "myotonic", "dystrophy"], "h": {"id": "C0553604", "name": "C0553604#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2931689", "name": "C2931689#ent", "pos": [23, 24]}}
{"token": ["More", "recently", "a", "second", "form", "of", "C0553604#ent", "<e1>", "been", "recognized", "and", "variously", "designated", "as", "C2931689#ent", "<e2>", "PROMM", ")", ",", "proximal", "myotonic", "dystrophy", "PDM", ")", ",", "or", "DM2", "."], "h": {"id": "C0553604", "name": "C0553604#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2931689", "name": "C2931689#ent", "pos": [14, 15]}}
{"token": ["Immunoblotting", "experiments", "confirmed", "the", "presence", "of", "C3811252#ent", "<e1>", "and", "VAMP-8", "but", "not", "C3811805#ent", "<e2>", "or", "VAMP-2", "in", "platelets", "."], "h": {"id": "C3811252", "name": "C3811252#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3811805", "name": "C3811805#ent", "pos": [12, 13]}}
{"token": ["We", "report", "a", "case", "of", "C0175778#ent", "<e1>", "respiratory", "difficulty", "to", "a", "C0040583#ent", "<e2>"], "h": {"id": "C0175778", "name": "C0175778#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0040583", "name": "C0040583#ent", "pos": [11, 12]}}
{"token": ["We", "have", "studied", "the", "natural", "anticoagulantion", "system", "a", "decade", ",", "and", "recently", "established", "C4049625#ent", "<e1>", "knockout", "mice", "well", "as", "C1419894#ent", "<e2>", "(", "syndecan-4", ")", "knockout", "mice"], "h": {"id": "C4049625", "name": "C4049625#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1419894", "name": "C1419894#ent", "pos": [19, 20]}}
{"token": ["Experimental", "data", "on", "the", "other", "hand", ",", "demonstrate", "a", "C0242912#ent", "<e1>", "and", "neurotrophic", "effect", "of", "this", "C1413053#ent", "<e2>"], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413053", "name": "C1413053#ent", "pos": [16, 17]}}
{"token": ["C0700444#ent", "<e1>", "Buspar", ")", "is", "a", "novel", "anxiolytic", "agent", "to", "the", "C4048284#ent", "<e2>", "or", "other", "psychotherapeutic", "agents"], "h": {"id": "C0700444", "name": "C0700444#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [11, 12]}}
{"token": ["The", "C0085399#ent", "<e1>", "have", "only", "been", "identified", "as", "C0991617#ent", "<e2>", "of", "human", "disease", "the", "United", "States", "the", "past", "few", "decades", ",", "and", "knowledge", "about", "them", "is", "still", "evolving", "."], "h": {"id": "C0085399", "name": "C0085399#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [8, 9]}}
{"token": ["Tip", "also", "mediates", "restriction", "of", "late-stage", "replication", "of", "HIV-1", "by", "disrupting", "C3273837#ent", "<e1>", "interaction", "with", "C3853652#ent", "<e2>", "Lck", ")", "in", "lipid", "rafts"], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3853652", "name": "C3853652#ent", "pos": [15, 16]}}
{"token": ["The", "Shh", "receptor", "Patched1", "(", "C1826732#ent", "<e1>", ")", "and", "its", "downstream", "effector", "Smoothened", "(", "C1364142#ent", "<e2>", ")", "were", "initial", "prime", "suspects", "they", "are", "membrane", "proteins", "cellular", "dynamics", "modulated", "by", "the", "Shh", "signal", "."], "h": {"id": "C1826732", "name": "C1826732#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1364142", "name": "C1364142#ent", "pos": [14, 15]}}
{"token": ["We", "have", "previously", "demonstrated", "that", "C1454182#ent", "<e1>", "PKCgamma", ")", "regulates", "gap", "junctions", "the", "lens", "epithelium", "C0001614#ent", "<e2>", "."], "h": {"id": "C1454182", "name": "C1454182#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [15, 16]}}
{"token": ["A", "13-day-old", "neonate", "suffered", "IVC", "thrombosis", "secondary", "to", "C0272375#ent", "<e1>", "possibly", "contributed", "to", "by", "a", "mutation", "in", "the", "C0066357#ent", "<e2>"], "h": {"id": "C0272375", "name": "C0272375#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0066357", "name": "C0066357#ent", "pos": [18, 19]}}
{"token": ["Semi-purified", "diets", "containing", "C0001962#ent", "<e1>", "7", "%", "sorbitol", "or", "7", "%", "C0064585#ent", "<e2>", "were", "fed", "to", "normal", "and", "cecectomized", "rats", "for", "16", "days", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0064585", "name": "C0064585#ent", "pos": [11, 12]}}
{"token": ["The", "ability", "of", "beta-phenylethylamine", "(", "PEA", ")", "to", "reverse", "(", "1", ")", "chlorpromazine-induced", "activation", "of", "C1420718#ent", "<e1>", "and", "(", "2", ")", "catalepsy", "produced", "by", "C0033229#ent", "<e2>", ",", "was", "examined", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033229", "name": "C0033229#ent", "pos": [24, 25]}}
{"token": ["The", "cellularity", "of", "lymph", "nodes", "adult", "mice", "was", "reduced", "by", "systemic", "blockade", "of", "C1416931#ent", "<e1>", "LTbeta", "R", "signaling", "with", "a", "C1420803#ent", "<e2>", "in", "resting", "and", "reactive", "settings", "."], "h": {"id": "C1416931", "name": "C1416931#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420803", "name": "C1420803#ent", "pos": [20, 21]}}
{"token": ["The", "results", "suggest", "that", "the", "Ca2", "+", ",", "C1333909#ent", "<e1>", "+", "-ATPase", "is", "responsible", "for", "driving", "the", "C0101555#ent", "<e2>", "Ca2", "+", "accumulation", "by", "this", "membrane", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [17, 18]}}
{"token": ["The", "MNA-SF", "allows", "quick", "screening", "to", "determine", "a", "C0795956#ent", "<e1>", "risk", "of", "C0162429#ent", "<e2>", "."], "h": {"id": "C0795956", "name": "C0795956#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [12, 13]}}
{"token": ["A", "clone", "was", "isolated", "that", "expresses", "a", "C1826560#ent", "<e1>", "termed", "PapA", "for", "C1421425#ent", "<e2>", "when", "examined", "by", "immunoblot", "analysis", "antibody", "raised", "to", "the", "particle", "."], "h": {"id": "C1826560", "name": "C1826560#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421425", "name": "C1421425#ent", "pos": [12, 13]}}
{"token": ["In", "C0162361#ent", "<e1>", "however", ",", "alopecia", "can", "be", "severe", ",", "C0022596#ent", "<e2>", "usually", "present", ",", "and", "hypo/oligodontia", "is", "not", "a", "prominent", "feature", "."], "h": {"id": "C0162361", "name": "C0162361#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0022596", "name": "C0022596#ent", "pos": [10, 11]}}
{"token": ["Male", "Sprague-Dawley", "rats", "pretreated", "for", "48", "h", "with", "vehicle", ",", "the", "MR", "antagonist", "C0037982#ent", "<e1>", ",", "or", "the", "GR", "antagonist", "C0026088#ent", "<e2>", "(", "RU486", ")", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026088", "name": "C0026088#ent", "pos": [20, 21]}}
{"token": ["Most", "important", ",", "HLA-B27", "associated", "arthritis", "may", "occur", "identical", "to", "the", "C0035012#ent", "<e1>", "accompanying", "ureteritis", "and/or", "conjunctivitis", ",", "whereas", "in", "the", "C1537935#ent", "<e2>", "non-associated", "form", "this", "has", "not", "been", "clearly", "described", "."], "h": {"id": "C0035012", "name": "C0035012#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1537935", "name": "C1537935#ent", "pos": [21, 22]}}
{"token": ["Kaposi's", "sarcoma", "8", "months", "after", "the", "start", "of", "C0006938#ent", "<e1>", "treatment", "in", "a", "70-year-old", "woman", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["C0006938#ent", "<e1>", "was", "therefore", "considered", "a", "potential", "slow-acting", "drug", "for", "treating", "C0003873#ent", "<e2>"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}}
{"token": ["Our", "study", "strengthens", "the", "argument", "that", "C0006938#ent", "<e1>", "can", "be", "used", "in", "therapy", "of", "C0003873#ent", "<e2>"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}}
{"token": ["It", "appears", "that", "the", "antenatal", "chemoprophylaxis", "with", "C0034283#ent", "<e1>", "(", "25", "mg", "weekly", ")", "currently", "used", "for", "C0024530#ent", "<e2>", "in", "our", "centre", "no", "longer", "protects", "the", "mother", "and", "fetus", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [17, 18]}}
{"token": ["C0442874#ent", "<e1>", "with", "IgM", "monoclonal", "gammopathy", "respond", "to", "various", "C0003392#ent", "<e2>", "although", "the", "long-term", "effects", "are", "unknown", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [9, 10]}}
{"token": ["C0442874#ent", "<e1>", "an", "important", "clinical", "problem", "the", "use", "of", "the", "C0003392#ent", "<e2>", "Taxol", "and", "thalidomide", "."], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [10, 11]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "the", "significance", "of", "fetal", "acidemia", "C0085584#ent", "<e1>", "C1366499#ent", "<e2>", ")", "and", "for", "the", "combination", "of", "C1366499#ent", "<e2>", "and", "multiorgan", "system", "dysfunction", "MOS", ")", "."], "h": {"id": "C0085584", "name": "C0085584#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366499", "name": "C1366499#ent", "pos": [15, 16]}}
{"token": ["Attempted", "ligation", "of", "DL-4,4-F2Glu", "to", "methotrexate", "(", "C1417487#ent", "<e1>", ")", ",", "catalyzed", "by", "human", "C0060626#ent", "<e2>", "FPGS", ")", ",", "revealed", "that", "DL-4,4-F2Glu", "is", "a", "poor", "alternate", "substrate", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0060626", "name": "C0060626#ent", "pos": [14, 15]}}
{"token": ["C1417487#ent", "<e1>", "is", "converted", "to", "gamma-glutamyl", "polyglutamates", ",", "an", "active", "form", "C1417487#ent", "<e1>", ",", "through", "the", "action", "of", "C0060626#ent", "<e1>", "the", "cells", "."], "h": {"id": "C1417487", "name": "C1417487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0060626", "name": "C0060626#ent", "pos": [18, 19]}}
{"token": ["When", "it", "occurs", ",", "local", "injection", "with", "C0887621#ent", "<e1>", ",", "steroids", ",", "or", "C0000783#ent", "<e2>", "help", ",", "but", "occasionally", ",", "removal", "of", "the", "offending", "suture(s", ")", "will", "be", "required", "."], "h": {"id": "C0887621", "name": "C0887621#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000783", "name": "C0000783#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "the", "hypothesis", "that", "C0246631#ent", "<e1>", "would", "depress", "the", "C3536742#ent", "<e2>", "response", "to", "pneumoperitoneum", "and", "laparoscopic", "surgery", "with", "a", "high", "dose", "HD", ")", "compared", "with", "a", "low", "dose", "LD", ")", "."], "h": {"id": "C0246631", "name": "C0246631#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [10, 11]}}
{"token": ["C1254351#ent", "<e1>", "animals", "showed", "significantly", "fewer", "C1415760#ent", "<e2>", "labeled", "cortical", "neurons", "at", "this", "time", "point"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [6, 7]}}
{"token": ["The", "early", "component", "the", "sAHP", "was", "selectively", "blocked", "by", "apamin", "and", "C0041345#ent", "<e1>", ",", "while", "the", "late", "component", "selectively", "blocked", "by", "C0035983#ent", "<e2>", ",", "procaine", "or", "phenylephrine", "."], "h": {"id": "C0041345", "name": "C0041345#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035983", "name": "C0035983#ent", "pos": [21, 22]}}
{"token": ["C3540783#ent", "<e1>", "have", "potential", "drug", "interactions", "warfarin", ",", "furosemide", "(", "C0016860#ent", "<e2>", ")", ",", "oral", "hypoglycaemics", "and", "probenecid", "."], "h": {"id": "C3540783", "name": "C3540783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [10, 11]}}
{"token": ["The", "transient", "expression", "of", "ABC7", "in", "mouse", "embryo", "liver", "BNL-CL2", "cells", "resulted", "in", "an", "increase", "in", "the", "activity", "and", "level", "of", "C0015880#ent", "<e1>", "and", "thioredoxin", ",", "a", "C1334332#ent", "<e2>", "iron-sulfur", "."], "h": {"id": "C0015880", "name": "C0015880#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [27, 28]}}
{"token": ["In", "conclusion", ",", "highly", "fluorescent", "MDCK", "cells", "in", "confluent", "C0872351#ent", "<e1>", "have", "a", "luminal", "DIDS", "inhibitable", ",", "C0007028#ent", "<e2>", "dependent", "Cl-/HCO3(-)-exchanger", ",", "and", "may", "therefore", "be", "used", "as", "a", "model", "for", "beta-intercalated", "cells"], "h": {"id": "C0872351", "name": "C0872351#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007028", "name": "C0007028#ent", "pos": [17, 18]}}
{"token": ["Chromatin", "immunoprecipitation", "analysis", "the", "endogenous", "C1420626#ent", "<e1>", "promoter", "showed", "increased", "association", "of", "p53", ",", "C1422492#ent", "<e2>", "(", "CBP", "and", "TRRAP", ")", ",", "and", "acetylated", "histones", "cell", "irradiation"], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [14, 15]}}
{"token": ["It", "was", "examined", "whether", "C1455060#ent", "<e1>", "can", "bind", "calmodulin", "in", "vivo", "whether", "C0812283#ent", "<e2>", "can", "bind", "calmodulin", ",", "and", "whether", "calmodulin", "is", "functionally", "involved", "in", "Ral", "activation"], "h": {"id": "C1455060", "name": "C1455060#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812283", "name": "C0812283#ent", "pos": [12, 13]}}
{"token": ["These", "results", "could", "help", "to", "elucidate", "the", "immunoregulatory", "activity", "PI", "and", "point", "out", "the", "beneficial", "effects", "of", "C0376637#ent", "<e1>", "in", "regulating", "DC", "functions", "and", "C0003308#ent", "<e2>"], "h": {"id": "C0376637", "name": "C0376637#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [24, 25]}}
{"token": ["Primary", "muscle", "disorders", "lead", "to", "C0011168#ent", "<e1>", "(", "for", "example", ",", "with", "C0011633#ent", "<e2>", "or", "oculopharyngeal", "dystrophy", "or", "defects", "of", "large", "bowel", "motility", "for", "example", ",", "with", "Duchenne's", "muscular", "dystrophy", "."], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011633", "name": "C0011633#ent", "pos": [12, 13]}}
{"token": ["Gerstmann-Str\u00e4ussler-Scheinker", "disease", "an", "C3899989#ent", "<e1>", "a", "wide", "spectrum", "of", "clinical", "presentations", "ataxia", ",", "spastic", "paraparesis", "C0234132#ent", "<e2>", "and", "dementia", "."], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0234132", "name": "C0234132#ent", "pos": [15, 16]}}
{"token": ["These", "findings", "suggest", "that", "the", "biochemical", "properties", "of", "these", "purified", "acharan", "sulfate", "lyases", "different", "from", "those", "of", "the", "previously", "purified", "C0024188#ent", "<e1>", "but", "these", "enzymes", "belong", "to", "C0062507#ent", "<e2>"], "h": {"id": "C0024188", "name": "C0024188#ent", "pos": [20, 21]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0062507", "name": "C0062507#ent", "pos": [27, 28]}}
{"token": ["Here", "we", "have", "examined", "the", "cellular", "and", "molecular", "effects", "a", "combined", "kinase", "inhibition", "C1307407#ent", "<e1>", "(", "rapamycin", ")", "and", "EGFR", "(", "EKI-785", ")", "in", "C1822629#ent", "<e2>", "and", "U251", "GBM", "cells"], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1822629", "name": "C1822629#ent", "pos": [24, 25]}}
{"token": ["By", "digestion", "with", "C0011518#ent", "<e1>", "a", "human", "hepatocellular", "carcinoma", "shown", "to", "contain", "only", "2", "hepatitis", "B", "virus", "C0019163#ent", "<e2>", ")", "DNA", "inserts", "."], "h": {"id": "C0011518", "name": "C0011518#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [17, 18]}}
{"token": ["Multiple", "sequence", "alignments", "functional", "substrate", "assays", "of", "C0034861#ent", "<e1>", "that", "AeDredd", "is", "an", "orthologue", "of", "Drosophila", "Dredd", "human", "C1705065#ent", "<e2>", ",", "both", "central", "effectors", "the", "death", "receptor-mediated", "apoptotic", "pathway"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [18, 19]}}
{"token": ["Preoperative", "serum", "examination", "increases", "in", "GOT", ",", "C1415274#ent", "<e1>", ",", "LDH", "and", "total", "bilirubin", "decreases", "in", "cholinesterase", "and", "C1412332#ent", "<e2>", ",", "and", "prolongation", "of", "prothrombin", "time"], "h": {"id": "C1415274", "name": "C1415274#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [18, 19]}}
{"token": ["Other", "growth", "factors", "including", "TGF-beta1", ",", "C1705751#ent", "<e1>", ",", "PDGF", ",", "EGF", ",", "IL-6", ",", "IGF-I", "and", "C1334091#ent", "<e2>", ",", "showed", "no", "activity", "tested", "alone", "."], "h": {"id": "C1705751", "name": "C1705751#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334091", "name": "C1334091#ent", "pos": [17, 18]}}
{"token": ["Taken", "together", ",", "these", "results", "suggest", "that", "the", "protamine-like", "domain", "in", "core", "C1305923#ent", "<e1>", "is", "a", "C3273678#ent", "<e2>", "is", "dispensable", "for", "the", "correct", "folding", "and", "assembly", "of", "amino-terminal", "and", "central", "regions", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273678", "name": "C3273678#ent", "pos": [16, 17]}}
{"token": ["The", "opioid", "codeine", "been", "a", "mainstay", "in", "the", "treatment", "of", "cough", "for", "decades", "and", "this", "C1254351#ent", "<e1>", "is", "widely", "regarded", "as", "the", "'", "gold", "standard", "C2723142#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2723142", "name": "C2723142#ent", "pos": [25, 26]}}
{"token": ["We", "think", "this", "is", "a", "distinct", "C2936904#ent", "<e1>", "variable", "expressivity", ",", "and", "have", "named", "the", "disorder", "the", "C2930866#ent", "<e2>"], "h": {"id": "C2936904", "name": "C2936904#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2930866", "name": "C2930866#ent", "pos": [17, 18]}}
{"token": ["It", "was", "treated", "with", "low", "molecular", "weight", "heparin", "C0019139#ent", "<e1>", ")", ",", "but", "in", "the", "presence", "of", "an", "allergy", "disorder", "C1254351#ent", "<e2>", "was", "discontinued", "and", "substituted", "by", "another", "C0019139#ent", "<e1>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [8, 9]}}
{"token": ["To", "explore", "the", "effect", "of", "arsenic", "trioxide", "C1336694#ent", "<e1>", "O3", ")", "on", "the", "level", "of", "C2349086#ent", "<e2>", ",", "VEGFR", "and", "the", "activity", "of", "MMP-2", ",", "9", "in", "K562", "cells"], "h": {"id": "C1336694", "name": "C1336694#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [15, 16]}}
{"token": ["Our", "results", "suggest", "that", "the", "truncated", "(", "I117A/L148A", ")", "C1704816#ent", "<e1>", "be", "an", "effective", ",", "safe", "antidote", "for", "human", "C0012546#ent", "<e2>", "."], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0012546", "name": "C0012546#ent", "pos": [19, 20]}}
{"token": ["We", "have", "recently", "demonstrated", "that", "two", "members", "of", "the", "family", "of", "C0135615#ent", "<e1>", "PC1", "and", "PC2", "play", "a", "significant", "role", "in", "C1421143#ent", "<e2>", "processing", "."], "h": {"id": "C0135615", "name": "C0135615#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [21, 22]}}
{"token": ["C0271713#ent", "<e1>", "KH", ")", "is", "a", "disease", "characterized", "by", "fasting", "C0020615#ent", "<e2>", "and", "increased", "levels", "of", "ketone", "bodies"], "h": {"id": "C0271713", "name": "C0271713#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [10, 11]}}
{"token": ["In", "animals", "with", "an", "unilateral", "C0085196#ent", "<e1>", "lesion", "of", "the", "nigrostriatal", "system", "acute", "administration", "C0025242#ent", "<e2>", "caused", "ipsilateral", "rotations", ",", "which", "were", "augmented", "following", "14", "days", "of", "infusion", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025242", "name": "C0025242#ent", "pos": [14, 15]}}
{"token": ["Plasma", "glucose", "lowered", "in", "type", "2", "diabetic", "patients", "by", "C0245514#ent", "<e1>", "or", "pioglitazone", "alone", "or", "in", "combination", "with", "C0038766#ent", "<e2>", "."], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [18, 19]}}
{"token": ["On", "rare", "occasions", ",", "these", "fevers", "can", "be", "attributed", "to", "potentially", "life-threatening", "occult", "infections", "including", "C0024959#ent", "<e1>", "acute", "cholecystitis", "antibiotic-related", "pseudomembranous", "colitis", ",", "toxic", "shock", "syndrome", "systemic", "candidiasis", "and", "C0010823#ent", "<e2>", "malaria", ",", "and", "babesiosis", "."], "h": {"id": "C0024959", "name": "C0024959#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [29, 30]}}
{"token": ["Antisera", "specific", "to", "PAX3", "and", "C1333572#ent", "<e1>", "were", "developed", "and", "used", "to", "examine", "PAX3", "and", "C1847791#ent", "<e2>", "expression", "in", "tumor", "cell", "lines"], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [5, 6]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1847791", "name": "C1847791#ent", "pos": [15, 16]}}
{"token": ["In", "order", "to", "investigate", "transcriptional", "regulation", "lymphokine", "genes", "rheumatic", "diseases", "peripheral", "blood", "mononuclear", "cells", "patients", "with", "systemic", "lupus", "erythematosus", "SLE", ")", ",", "rheumatoid", "arthritis", "RA", ")", ",", "and", "C0036421#ent", "<e1>", "SSc", ")", "were", "analysed", "for", "expression", "of", "C0812382#ent", "<e2>"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [37, 38]}}
{"token": ["The", "amino-terminal", "fifty", "C3539946#ent", "<e1>", "EBNA1", "of", "both", "C0149678#ent", "<e2>", "and", "HVP", "weakly", "resemble", "the", "amino", "terminus", "of", "rat", "ribosomal", "protein", "S2"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [8, 9]}}
{"token": ["These", "results", "indicate", "that", "some", "of", "the", "beneficial", "effects", "associated", "with", "dwarf", "phenotype", "may", "be", "caused", "by", "C0669365#ent", "<e1>", "activation", "of", "C2984537#ent", "<e2>", "and", "regulated", "genes"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2984537", "name": "C2984537#ent", "pos": [21, 22]}}
{"token": ["Treatment", "of", "adrenalectomized", "rats", "for", "14", "days", "with", "10", "mg/kg", "C1705616#ent", "<e1>", "produced", "down-regulation", "of", "hippocampal", "C1334899#ent", "<e2>", "binding", "in", "a", "manner", "also", "reported", "following", "high", "glucocorticoid", "administration", "."], "h": {"id": "C1705616", "name": "C1705616#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "suggest", "that", "the", "allodynic", "effects", "of", "C1705889#ent", "<e1>", "in", "this", "procedure", "were", "mediated", "entirely", "by", "C1565830#ent", "<e2>", "arachidonic", "acid", "metabolism", ",", "such", "as", "PGE2", "."], "h": {"id": "C1705889", "name": "C1705889#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [17, 18]}}
{"token": ["Since", "phosphorylation", "of", "C1382029#ent", "<e1>", "Raf-1", "protein", "kinase", "recently", "shown", ",", "we", "tested", "the", "role", "of", "C0139905#ent", "<e2>", "in", "adenylyl", "cyclase", "in", "hDOR/CHO", "cells", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [16, 17]}}
{"token": ["p38", "MAPK", "necessary", "for", "C1516468#ent", "<e1>", "drug-induced", "cell", "death", "because", "the", "C0257535#ent", "<e2>", "SB203580", "or", "SB202190", "suppressed", "cell", "death"], "h": {"id": "C1516468", "name": "C1516468#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [11, 12]}}
{"token": ["While", "it", "is", "proven", "that", "C0079805#ent", "<e1>", "activates", "APC", ",", "new", "data", "suggest", "that", "C0079805#ent", "<e1>", "inhibits", "C1413256#ent", "<e1>", ",", "i.e.", ",", "that", "C0079805#ent", "<e1>", "and", "C1413256#ent", "<e1>", "are", "antagonists", "."], "h": {"id": "C0079805", "name": "C0079805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413256", "name": "C1413256#ent", "pos": [17, 18]}}
{"token": ["However", ",", "the", "scavenger", "receptor", "fucoidin", "competed", "the", "C1332924#ent", "<e1>", "uptake", "beyond", "that", "accounted", "for", "by", "C3811244#ent", "<e2>", ",", "indicating", "that", "another", "scavenger", "receptor(s)", "also", "contribute", "."], "h": {"id": "C1332924", "name": "C1332924#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3811244", "name": "C3811244#ent", "pos": [16, 17]}}
{"token": ["Similarly", ",", "ectopic", "expression", "of", "C3887789#ent", "<e1>", "P/CAF", ")", ",", "which", "transduces", "C1366462#ent", "<e2>", "effects", ",", "or", "of", "HAT-defective", "P/CAF", "did", "not", "influence", "the", "c-jun", "effects", "."], "h": {"id": "C3887789", "name": "C3887789#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1366462", "name": "C1366462#ent", "pos": [12, 13]}}
{"token": ["The", "fluorescence", "of", "C1822725#ent", "<e1>", "increases", "in", "the", "presence", "of", "C0009325#ent", "<e2>", "."], "h": {"id": "C1822725", "name": "C1822725#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [10, 11]}}
{"token": ["The", "tyrosyl", "phosphorylated", "state", "of", "C1420554#ent", "<e1>", "is", "dependent", "on", "C0029009#ent", "<e2>", "the", "unknown", "protein", "tyrosine", "phosphate", "phosphohydrolase", "PTPase", ",", "EC", "3.1.3.48", ")", "."], "h": {"id": "C1420554", "name": "C1420554#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029009", "name": "C0029009#ent", "pos": [10, 11]}}
{"token": ["For", "example", ",", "conversion", "of", "the", "sole", "lysine", "residue", "glucagon", "to", "C0019877#ent", "<e1>", "resulted", "in", "over", "a", "2-fold", "loss", "in", "C1709139#ent", "<e2>", "affinity", "."], "h": {"id": "C0019877", "name": "C0019877#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1709139", "name": "C1709139#ent", "pos": [20, 21]}}
{"token": ["Further", "consideration", "should", "be", "given", "to", "I.", "cookei", "as", "a", "possible", "vector", "of", "C0038041#ent", "<e1>", "group", "rickettsiae", "spirochetes", "that", "cause", "C0006035#ent", "<e2>"], "h": {"id": "C0038041", "name": "C0038041#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006035", "name": "C0006035#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "angiotensin", "II", "be", "produced", "in", "various", "tissues", "by", "C3540790#ent", "<e1>", "of", "the", "renin-angiotensin", "system", "RAS", ")", "or", "the", "nonrenin-angiotensin", "system", "C0027260#ent", "<e2>", ")", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027260", "name": "C0027260#ent", "pos": [23, 24]}}
{"token": ["It", "is", "unclear", "how", "hepatic", "adiponectin", "resistance", "and", "sensitivity", "mediated", "by", "the", "C1540188#ent", "<e1>", "AdipoR2", ",", "contributes", "to", "the", "progression", "of", "C2711227#ent", "<e2>", "NASH", ")", "."], "h": {"id": "C1540188", "name": "C1540188#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [21, 22]}}
{"token": ["Effects", "of", "local", "anesthetics", "dibucaine", ",", "C0006400#ent", "<e1>", "and", "lidocaine", "on", "the", "phase", "transition", "of", "C0000039#ent", "<e2>", "(", "DPPC", ")", "bilayer", "membrane", "studied", "by", "the", "optical", "method"], "h": {"id": "C0006400", "name": "C0006400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0000039", "name": "C0000039#ent", "pos": [15, 16]}}
{"token": ["In", "all", "patients", "there", "was", "rapid", "improvement", "from", "the", "C0031065#ent", "<e1>", ",", "pneumonitis", ",", "cytopenia", ",", "CNS", "abnormalities", "C0031069#ent", "<e2>", "."], "h": {"id": "C0031065", "name": "C0031065#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [18, 19]}}
{"token": ["Adrenalectomy", "did", "not", "affect", "C1417932#ent", "<e1>", "activity", ",", "but", "pretreatment", "with", "the", "C0003286#ent", "<e2>", "MK-801", "caused", "a", "depression", "of", "the", "induced", "levels", "of", "enzyme", "activity"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [12, 13]}}
{"token": ["The", "induction", "of", "human", "C1382176#ent", "<e1>", "and", "the", "rat", "(", "C0534137#ent", "<e2>", ")", "and", "mouse", "(", "Cyp2b10", ")", "homologues", "by", "PB", "is", "mediated", "by", "the", "nuclear", "receptor", "constitutive", "androstane", "receptor", "CAR", ")", "."], "h": {"id": "C1382176", "name": "C1382176#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [10, 11]}}
{"token": ["Bupropion", "is", "used", "as", "a", "probe", "for", "the", "activity", "of", "the", "C1382176#ent", "<e1>", "isoenzyme", "of", "the", "C0534137#ent", "<e2>", "enzymes", "in", "man", "."], "h": {"id": "C1382176", "name": "C1382176#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [16, 17]}}
{"token": ["Cotransfection", "of", "these", "reporter", "constructs", "with", "wild-type", "C1414463#ent", "<e1>", "or", "VP16-ERRalpha", "expression", "vectors", "C1414463#ent", "<e1>", "enhanced", "reporter", "activity", "by", "flanking", "DNA", "C1706114#ent", "<e1>", "and", "SULT2A1", "."], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706114", "name": "C1706114#ent", "pos": [21, 22]}}
{"token": ["C1366489#ent", "<e1>", "small", "interfering", "RNA", "or", "smaller", "molecules", "that", "can", "degrade", "C0070942#ent", "<e2>", "be", "developed", "as", "alternative", "approaches", "to", "treat", "the", "prostate", "cancer"], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0070942", "name": "C0070942#ent", "pos": [11, 12]}}
{"token": ["A", "diagnosis", "of", "C3273682#ent", "<e1>", "was", "made", "and", "the", "patient", "treated", "with", "C0032950#ent", "<e2>", "1", "mg/kg/day", "."], "h": {"id": "C3273682", "name": "C3273682#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "we", "show", "that", "CUG-BP", ",", "the", "human", "homologue", "of", "C1413824#ent", "<e1>", ",", "specifically", "binds", "to", "C0162508#ent", "<e2>"], "h": {"id": "C1413824", "name": "C1413824#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [17, 18]}}
{"token": ["In", "two", "female", "patients", "of", "62", "and", "81", "years", "old", ",", "a", "C0006112#ent", "<e1>", "diagnosed", "which", "was", "ascribed", "to", "the", "use", "of", "C0042291#ent", "<e2>"], "h": {"id": "C0006112", "name": "C0006112#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [22, 23]}}
{"token": ["Mycobacterium", "smegmatis", "N.C.T.C.", "8158", ")", ",", "M.", "fortuitum", "and", "M.", "phlei", "(", "C1417244#ent", "<e1>", ")", "produce", "a", "C0907533#ent", "<e2>", "beta-lactamase", "that", "has", "penicillinase", "and", "cephalosporinase", "activity"], "h": {"id": "C1417244", "name": "C1417244#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [17, 18]}}
{"token": ["Treatment", "of", "the", "cells", "with", "C1420423#ent", "<e1>", "also", "led", "to", "an", "increased", "mRNA", "expression", "of", "gamma-glutamylcysteine", "ligase", "catalytic", "subunit", "C1415097#ent", "<e2>", ")", "and", "NQO1", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415097", "name": "C1415097#ent", "pos": [19, 20]}}
{"token": ["We", "have", "cloned", "genes", "encoding", "these", "three", "C1456380#ent", "<e1>", "termed", "RBP63", ",", "RBP45", ",", "and", "C1705438#ent", "<e2>", ",", "and", "characterized", "their", "binding", "properties", "."], "h": {"id": "C1456380", "name": "C1456380#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705438", "name": "C1705438#ent", "pos": [15, 16]}}
{"token": ["The", "lysosomal", "degradation", "C0017768#ent", "<e1>", "requires", "the", "C1334064#ent", "<e2>", ",", "glucosylceramide-beta-glucosidase", "and", "a", "sphingolipid", "activator", "protein", "Gaucher", "factor", ",", "SAP-2", ",", "saposin", "C", "."], "h": {"id": "C0017768", "name": "C0017768#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334064", "name": "C1334064#ent", "pos": [7, 8]}}
{"token": ["Forty-two", "male", "C0029001#ent", "<e1>", "patients", "received", "C0022322#ent", "<e2>", "(", "200", "mug/kg", ")", "alone", ",", "albendazole", "(", "400", "mg", ")", "alone", "or", "the", "combination", "."], "h": {"id": "C0029001", "name": "C0029001#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0022322", "name": "C0022322#ent", "pos": [6, 7]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "investigate", "the", "C1414909#ent", "<e1>", "another", "collection", "of", "C0017363#ent", "<e2>"], "h": {"id": "C1414909", "name": "C1414909#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [14, 15]}}
{"token": ["Molecular", "characterisation", "of", "the", "gp100", "cDNA", "that", "the", "gp100", "antigen", "highly", "C1512488#ent", "<e1>", ",", "but", "not", "identical", ",", "to", "another", "C1416925#ent", "<e2>", "pMel17", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416925", "name": "C1416925#ent", "pos": [20, 21]}}
{"token": ["The", "highest", "cyclooxygenase-2", "expression", "was", "found", "with", "C0031990#ent", "<e1>", "and", "the", "lowest", "expression", "was", "with", "C0538927#ent", "<e2>", "."], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [15, 16]}}
{"token": ["PACAP", "has", "been", "shown", "to", "induce", "PC12", "cell", "neurite", "outgrowth", "through", "the", "C0169101#ent", "<e1>", "MEK", ")", "pathway", "independently", "of", "C0033640#ent", "<e2>", "PKA", ")", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [12, 13]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [19, 20]}}
{"token": ["C1422492#ent", "<e1>", "ER", "colocalize", "with", "C1870412#ent", "<e2>", "variants", "in", "the", "spots", "in", "the", "presence", "of", "agonists", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1870412", "name": "C1870412#ent", "pos": [5, 6]}}
{"token": ["Nifedipine", "also", "reduced", "the", "C0304402#ent", "<e1>", "effect", "of", "C0004855#ent", "<e2>", "45Ca", "uptake", "in", "the", "presence", "of", "all", "three", "agonists", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004855", "name": "C0004855#ent", "pos": [8, 9]}}
{"token": ["The", "purpose", "of", "this", "investigation", "was", "to", "analyze", "prospectively", "the", "influence", "of", "serum", "estradiol", "levels", "and", "C0262586#ent", "<e1>", "on", "common", "clinical", "measurements", "C0017563#ent", "<e2>", "a", "2-year", "period", "."], "h": {"id": "C0262586", "name": "C0262586#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [22, 23]}}
{"token": ["During", "the", "period", "of", "C0036572#ent", "<e1>", "both", "the", "increase", "in", "C1705296#ent", "<e2>", "and", "the", "decrease", "in", "RBF", "in", "response", "to", "intravenous", "boluses", "norepinephrine", "fell", "to", "55", "%", "of", "the", "preseizure", "value", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705296", "name": "C1705296#ent", "pos": [10, 11]}}
{"token": ["The", "enhanced", "release", "of", "calcium", "from", "IP3-mediated", "C1414461#ent", "<e1>", "stores", "in", "C1704871#ent", "<e2>", "neurons", "stimulated", "increased", "NF-kappaB", "compared", "to", "normal", "neurons", ",", "which", "inhibited", "CHOP", "expression", "."], "h": {"id": "C1414461", "name": "C1414461#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704871", "name": "C1704871#ent", "pos": [11, 12]}}
{"token": ["The", "C0086376#ent", "<e1>", "encoded", "by", "C4284183#ent", "<e2>", "and", "other", "mitochondrial", "mRNAs", "characterized", "are", "part", "of", "the", "mitochondrial", "respiratory", "chain", "produces", "adenosine", "triphosphate", "the", "process", "of", "oxidative", "phosphorylation"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4284183", "name": "C4284183#ent", "pos": [5, 6]}}
{"token": ["The", "dementia-like", "cognitive", "profile", "of", "C3273837#ent", "<e1>", "a", "promising", "model", "for", "studying", "comparable", "cognitive", "deficits", "associated", "with", "C0751870#ent", "<e2>"], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [17, 18]}}
{"token": ["C0754570#ent", "<e1>", "is", "a", "promising", "anticancer", "alkylphospholipid", "C1826354#ent", "<e2>", ")", "that", "induces", "apoptosis", "in", "tumor", "cells"], "h": {"id": "C0754570", "name": "C0754570#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826354", "name": "C1826354#ent", "pos": [7, 8]}}
{"token": ["C0272412#ent", "<e1>", "a", "previously", "unreported", "complication", "of", "C0343386#ent", "<e2>"], "h": {"id": "C0272412", "name": "C0272412#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0343386", "name": "C0343386#ent", "pos": [7, 8]}}
{"token": ["C0813872#ent", "<e1>", "or", "C0010976#ent", "<e2>", ",", "but", "not", "FK506", ",", "suppressed", "convulsive", "seizures", "EL", "mice", "only", "C0813872#ent", "<e1>", "reduced", "NOx", "in", "the", "brain", "."], "h": {"id": "C0010976", "name": "C0010976#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [0, 1]}}
{"token": ["C0005064#ent", "<e1>", "were", "most", "commonly", "used", "followed", "by", "C0050537#ent", "<e2>", "ethanol", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0050537", "name": "C0050537#ent", "pos": [8, 9]}}
{"token": ["It", "inhibited", "C0001492#ent", "<e1>", "measured", "by", "C1421428#ent", "<e2>", "and", "enhanced", "Ca(2+)", "mobilization", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421428", "name": "C1421428#ent", "pos": [6, 7]}}
{"token": ["No", "effect", "of", "UDP-glucose", "was", "seen", "on", "C0001492#ent", "<e1>", "activity", "as", "measured", "by", "C1421428#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421428", "name": "C1421428#ent", "pos": [13, 14]}}
{"token": ["Growth", "factors", "C0026249#ent", "<e1>", ",", "and", "malignant", "transformation", "alter", "the", "rate", "of", "C2917660#ent", "<e2>", "uptake", "in", "mammalian", "cells"], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [12, 13]}}
{"token": ["C0214192#ent", "<e1>", "(", "9-AC", ")", "is", "a", "C1458146#ent", "<e2>", "inhibitor", "currently", "being", "developed", "as", "an", "antineoplastic", "agent"], "h": {"id": "C0214192", "name": "C0214192#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C1458146", "name": "C1458146#ent", "pos": [7, 8]}}
{"token": ["Seven", "of", "the", "C0019069#ent", "<e1>", "A", "carriers", "and", "none", "of", "the", "C0008533#ent", "<e2>", "carriers", "had", "a", "skewed", "pattern", "(", ">", "or", "=", "80:20", ")", "."], "h": {"id": "C0019069", "name": "C0019069#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "report", "the", "successful", "response", "to", "C1099414#ent", "<e1>", "%", "cream", "in", "a", "patient", "with", "steroid", "resistant", "C0080159#ent", "<e2>"], "h": {"id": "C1099414", "name": "C1099414#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0080159", "name": "C0080159#ent", "pos": [18, 19]}}
{"token": ["Probably", "pentobarbitone", ",", "etomidate", "or", "a", "benzodiazepine", "should", "be", "preferred", "as", "an", "alternative", "to", "C0936073#ent", "<e1>", "when", "the", "use", "of", "C0001637#ent", "<e2>", "is", "anticipated", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001637", "name": "C0001637#ent", "pos": [20, 21]}}
{"token": ["Another", "metalloendoprotease", "inhibitor", "C0070915#ent", "<e1>", ",", "which", "had", "no", "effect", "fusion", ",", "inhibits", "only", "the", "C0256102#ent", "<e2>"], "h": {"id": "C0070915", "name": "C0070915#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0256102", "name": "C0256102#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "an", "unusual", "family", "with", "a", "fatal", "genetic", "syndrome", "C0158981#ent", "<e1>", "DM", ")", ",", "enteropathy", ",", "C0339143#ent", "<e2>", ",", "and", "severe", "infections", "with", "variable", "thrombocytopenia"], "h": {"id": "C0158981", "name": "C0158981#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [17, 18]}}
{"token": ["Our", "results", "suggest", "that", "C0011777#ent", "<e1>", "produces", "acute", "improvement", "infants", "with", "C0034049#ent", "<e2>", "no", "long-term", "effect", "on", "mortality", "rate", "duration", "of", "oxygen", "requirement", "age", "at", "discharge", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034049", "name": "C0034049#ent", "pos": [11, 12]}}
{"token": ["However", ",", "once", "C1414435#ent", "<e1>", "body", "mass", "were", "achieved", ",", "they", "increased", "their", "C1442521#ent", "<e2>", "intake", ",", "and", "thus", "fat", "consumption"], "h": {"id": "C1414435", "name": "C1414435#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [13, 14]}}
{"token": ["By", "contrast", "with", "C0078956#ent", "<e1>", ",", "low", "affinity", "binding", "of", "SAPD", "was", "inhibited", "by", "C0041073#ent", "<e2>", "(", "DAG", ")", ",", "while", "binding", "to", "the", "high", "affinity", "site", "markedly", "enhanced", "."], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041073", "name": "C0041073#ent", "pos": [14, 15]}}
{"token": ["C0749139#ent", "<e1>", "and", "quinolone", "antibiotics", "and", "C0358430#ent", "<e2>", "also", "frequently", "induce", "reactions", "."], "h": {"id": "C0749139", "name": "C0749139#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0358430", "name": "C0358430#ent", "pos": [6, 7]}}
{"token": ["Cells", "that", "carry", "mutant", "p53", "proteins", "overexpress", "C1425999#ent", "<e1>", "and", "are", "unable", "to", "sustain", "C0033036#ent", "<e2>", "inactivation", "and", "mitotic", "arrest"], "h": {"id": "C1425999", "name": "C1425999#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [14, 15]}}
{"token": ["C1705280#ent", "<e1>", "is", "a", "small", "polypeptide", "found", "in", "C1336623#ent", "<e2>", "rat", "pituitary", "tumor", "cells", "expression", "is", "tightly", "linked", "to", "the", "expression", "of", "rat", "GH", "(", "rGH", ")", "at", "a", "genetic", "level"], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336623", "name": "C1336623#ent", "pos": [8, 9]}}
{"token": ["Deletion", "of", "the", "zinc", "fingers", "C3273675#ent", "<e1>", "resulted", "in", "loss", "of", "both", "C0812382#ent", "<e2>", "and", "transforming", "properties", "of", "TAF15-CIZ", ",", "whereas", "deletion", "of", "the", "other", "functional", "domains", "of", "C3273675#ent", "<e1>", "had", "no", "effect"], "h": {"id": "C3273675", "name": "C3273675#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [12, 13]}}
{"token": ["Taken", "together", ",", "our", "results", "reported", "here", "suggest", "that", "transformation", "of", "3T3", "fibroblasts", "C3273675#ent", "<e1>", "fusions", "is", "dependent", "on", "C0812382#ent", "<e2>", "and", "might", "involve", "transactivation", "of", "C3273675#ent", "<e1>", "target", "genes", "."], "h": {"id": "C3273675", "name": "C3273675#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812382", "name": "C0812382#ent", "pos": [19, 20]}}
{"token": ["Carboxylic", "acids", "CAs", ")", ",", "especially", "butyric", "acid", "have", "been", "suggested", "to", "counteract", "C0009373#ent", "<e1>", "such", "as", "C0009324#ent", "<e2>", "colon", "cancer"], "h": {"id": "C0009373", "name": "C0009373#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [17, 18]}}
{"token": ["The", "low", "dose", "C0287041#ent", "<e1>", "markedly", "reduced", "the", "dual", "immunoreactivity", "for", "FOS", "and", "C1334081#ent", "<e2>", "in", "the", "supraoptic", "nuclei", "paraventricular", "nuclei", "i.c.v", "."], "h": {"id": "C0287041", "name": "C0287041#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334081", "name": "C1334081#ent", "pos": [13, 14]}}
{"token": ["C0339971#ent", "<e1>", "complicated", "with", "acute", "respiratory", "distress", "syndrome", "C0035222#ent", "<e2>", ")", "is", "very", "rare", "in", "adults", "and", "is", "associated", "with", "morbimortality", "."], "h": {"id": "C0339971", "name": "C0339971#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [8, 9]}}
{"token": ["C0339971#ent", "<e1>", "complicated", "with", "C0035222#ent", "<e2>", "ARDS", ")", "is", "very", "rare", "in", "adults", "and", "is", "associated", "with", "morbimortality", "."], "h": {"id": "C0339971", "name": "C0339971#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [4, 5]}}
{"token": ["The", "senior", "author", "'s", "(", "C0079941#ent", "<e1>", ")", "clinical", "experience", "with", "more", "than", "5000", "C0751003#ent", "<e2>", "reviewed", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [14, 15]}}
{"token": ["Infectious", "C1843013#ent", "<e1>", "macropinocytosis", "required", "viral", "activation", "C1505379#ent", "<e2>", "PAK1", ")", "and", "the", "C-terminal", "binding", "protein", "1", "E1A", "(", "CtBP1", ")", ",", "recruited", "to", "macropinosomes", "."], "h": {"id": "C1843013", "name": "C1843013#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1505379", "name": "C1505379#ent", "pos": [7, 8]}}
{"token": ["A", "few", "days", "after", "a", "judo", "session", ",", "an", "11-year-old", "boy", "presented", "with", "an", "C0948008#ent", "<e1>", "dizziness", ",", "aphasia", "and", "C0004134#ent", "<e2>", "."], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [20, 21]}}
{"token": ["With", "all", "three", "C1947941#ent", "<e1>", ",", "no", "changes", "in", "the", "relative", "rates", "of", "C0026455#ent", "<e2>", "and", "MAO-B", "inactivation", "were", "observed", "after", "disruption", "of", "the", "mitochondria", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026455", "name": "C0026455#ent", "pos": [13, 14]}}
{"token": ["THus", ",", "although", "the", "C1416161#ent", "<e1>", "the", "whole", "was", "slightly", "more", "exposed", "in", "C0071610#ent", "<e2>", "in", "IgM", ",", "it", "was", "more", "homogeneously", "available", "in", "the", "latter", "polymer", "."], "h": {"id": "C1416161", "name": "C1416161#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0071610", "name": "C0071610#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "review", "the", "current", "knowledge", "on", "the", "determinants", "of", "A.", "pleuropneumoniae", "pathogenicity", ",", "paying", "particular", "attention", "to", "the", "capsule", ",", "the", "C0032594#ent", "<e1>", ",", "the", "outer", "membrane", "proteins", "and", "the", "C0073081#ent", "<e2>", "exotoxins", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0073081", "name": "C0073081#ent", "pos": [31, 32]}}
{"token": ["The", "activity", "of", "C1261253#ent", "<e1>", "(", "NAT", ")", "and", "C1413138#ent", "<e2>", "was", "measured", "in", "the", "tissues", "of", "placenta", ",", "full", "venous", "blood", "full", "umbilical", "cord", "blood", "141", "complicated", "pregnancies", "."], "h": {"id": "C1261253", "name": "C1261253#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413138", "name": "C1413138#ent", "pos": [9, 10]}}
{"token": ["Exogenous", "activation", "of", "nicotinic", "receptors", "application", "of", "various", "nicotinic", "agonists", "excited", "C0795996#ent", "<e1>", "at", "low", "C0243192#ent", "<e2>", "concentrations", "."], "h": {"id": "C0795996", "name": "C0795996#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [15, 16]}}
{"token": ["The", "data", "of", "C0043891#ent", "<e1>", "and", "mortality", "indicated", "that", "BCOE", "could", "increase", "the", "C0003392#ent", "<e2>", "CSOE", "and", "reduced", "the", "toxicity", "of", "BJOE", "."], "h": {"id": "C0043891", "name": "C0043891#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [13, 14]}}
{"token": ["When", "equipotent", "doses", "to", "oppose", "5-hydroxytryptamine-induced", "C0006266#ent", "<e1>", "were", "compared", ",", "rimiterol", "and", "C0001927#ent", "<e2>", "produced", "less", "tachycardia", "than", "did", "laevoisoprenaline", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [13, 14]}}
{"token": ["To", "compare", "the", "outcome", "of", "patients", "with", "C0006266#ent", "<e1>", "treated", "with", "nebulized", "C0001927#ent", "<e2>", "plus", "ipratropium", "bromide", "C0001927#ent", "<e2>", "alone", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0001927", "name": "C0001927#ent", "pos": [12, 13]}}
{"token": ["C0170168#ent", "<e1>", "MAPK", ")", "phosphatase", "3", "(", "C1414187#ent", "<e2>", ")", "is", "a", "well-known", "negative", "regulator", "in", "the", "Ras/extracellular", "signal-regulated", "kinase", "(ERK)-MAPK", "signaling", "pathway", "responsible", "for", "cell", "fate", "determination", "and", "proliferation", "during", "development", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414187", "name": "C1414187#ent", "pos": [7, 8]}}
{"token": ["Microinjection", "of", "active", "mammalian", "MAP", "kinase", "phosphatase", "C1414187#ent", "<e1>", ")", "resulted", "in", "inactivation", "of", "C0170168#ent", "<e2>", "unfertilized", "eggs", ",", "as", "did", "addition", "of", "C1414187#ent", "<e1>", "to", "lysates", "of", "unfertilized", "eggs", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414187", "name": "C1414187#ent", "pos": [7, 8]}}
{"token": ["C0272242#ent", "<e1>", "A2", "in", "mice", "leads", "to", "a", "lack", "of", "C0078956#ent", "<e2>", "cofactor", "activity", ",", "accumulation", "of", "intravascular", "fibrin", "and", "failure", "to", "clear", "arterial", "thrombi"], "h": {"id": "C0272242", "name": "C0272242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [10, 11]}}
{"token": ["We", "believe", "this", "is", "a", "distinct", "disorder", "and", "propose", "the", "acronym", "C1424628#ent", "<e1>", "for", "hydrocephalus", ",", "C0014117#ent", "<e2>", "and", "cataracts", "."], "h": {"id": "C1424628", "name": "C1424628#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014117", "name": "C0014117#ent", "pos": [16, 17]}}
{"token": ["The", "cell-seeded", "matrices", "were", "digested", "in", "C1947941#ent", "<e1>", "and", "analyzed", "for", "C0017346#ent", "<e2>", "by", "a", "modification", "of", "the", "dimethyl-methylene", "blue", "method", "assayed", "for", "DNA", "content"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [11, 12]}}
{"token": ["C1420193#ent", "<e1>", "males", "attracted", "significantly", "more", "females", "than", "did", "C1415842#ent", "<e2>", "males", "(", "63", "%", "vs.", "to", "37", "%", ")", "."], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415842", "name": "C1415842#ent", "pos": [9, 10]}}
{"token": ["Four", "individuals", "had", "a", "history", "of", "C0235522#ent", "<e1>", "a", "further", "2", "gave", "a", "history", "of", "C0235501#ent", "<e2>", "the", "remaining", "25", "individuals", "were", "asymptomatic", "."], "h": {"id": "C0235522", "name": "C0235522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0235501", "name": "C0235501#ent", "pos": [15, 16]}}
{"token": ["The", "results", "suggested", "that", "there", "was", "a", "correlation", "between", "blood", "and", "tissue", "fibrinolytic", "activity", "that", "certain", "C0235522#ent", "<e1>", "particularly", "recurrent", "C0235501#ent", "<e2>", "venous", "liposclerosis", ",", "were", "associated", "with", "deficiency", "of", "blood", "and", "tissue", "fibrinolytic", "activity"], "h": {"id": "C0235522", "name": "C0235522#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0235501", "name": "C0235501#ent", "pos": [20, 21]}}
{"token": ["The", "kinetics", "of", "expression", "of", "BMRF1", "gene", "product", "(", "early", "antigen", "diffuse", "component", ";", "EA-D", ")", "paralleled", "that", "of", "EBV", "deoxyribonuclease", "C0011519#ent", "<e1>", ")", "and", "of", "C0082328#ent", "<e2>"], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0082328", "name": "C0082328#ent", "pos": [26, 27]}}
{"token": ["DNA", "hydrolyzed", "by", "C0011519#ent", "<e1>", "as", "substrates", "both", "for", "C0082328#ent", "<e2>", "ligase", ",", "and", "the", "nicks", "therefore", "contain", "5'-phosphoryl", "and", "3'-hydroxyl", "groups", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0082328", "name": "C0082328#ent", "pos": [9, 10]}}
{"token": ["C0015056#ent", "<e1>", ",", "a", "diaphorase", "inhibitor", "and", "1-bromoheptane", ",", "a", "GSH", "C3850172#ent", "<e2>", "increased", "ASA", "toxicity", "toward", "SK-MEL-28", "cells", "indicating", "quinone", "formation", "intracellular", "GSH", "depletion", "played", "important", "mechanistic", "roles", "in", "ASA-induced", "melanoma", "toxicity", "."], "h": {"id": "C0015056", "name": "C0015056#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3850172", "name": "C3850172#ent", "pos": [11, 12]}}
{"token": ["It", "was", "concluded", "that", "the", "combined", "preparation", "consisting", "of", "C0021246#ent", "<e1>", "and", "sodium-salicylate", "has", "a", "favourable", "effect", "in", "C0038013#ent", "<e2>"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "C0021246#ent", "<e1>", "does", "not", "influence", "the", "intragastric", "pH", "C0038013#ent", "<e2>", "patients", "irrespective", "of", "history", "of", "peptic", "ulcer", "disease"], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [11, 12]}}
{"token": ["Numerous", "charged", "active-site", "residues", "are", "conserved", "within", "C0031727#ent", "<e1>", "but", "few", "are", "conserved", "within", "the", "C0031727#ent", "<e1>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}}
{"token": ["A", "photosensitive", "form", "of", "C1955934#ent", "<e1>", "(", "TTD", ")", "results", "from", "mutations", "in", "the", "same", "C1705972#ent", "<e2>", "the", "DNA-repair-deficient", "genetic", "disorder", "xeroderma", "pigmentosum", "group", "D", "XP-D", ")", "."], "h": {"id": "C1955934", "name": "C1955934#ent", "pos": [4, 5]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705972", "name": "C1705972#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "we", "show", "that", "C1425248#ent", "<e1>", "interact", "physically", "with", "C1422622#ent", "<e2>", "and", "p53", "."], "h": {"id": "C1425248", "name": "C1425248#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422622", "name": "C1422622#ent", "pos": [11, 12]}}
{"token": ["The", "interaction", "of", "C1367475#ent", "<e1>", "with", "C1421249#ent", "<e2>", "this", "complex", "provides", "a", "possible", "mechanism", "for", "transmembrane", "signal", "transduction", "C1367475#ent", "<e1>", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1367475", "name": "C1367475#ent", "pos": [3, 4]}}
{"token": ["This", "single", "nucleotide", "polymorphism", "plasma", "C3273681#ent", "<e1>", "and", "the", "resulting", "C0149676#ent", "<e2>", "thought", "to", "be", "a", "genetic", "risk", "factor", "various", "inflammatory", "diseases", "Japanese", "subjects", "."], "h": {"id": "C3273681", "name": "C3273681#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149676", "name": "C0149676#ent", "pos": [10, 11]}}
{"token": ["In", "this", "paper", ",", "we", "show", "that", "Spi-1/PU.1", "impedes", "the", "binding", "of", "C2347319#ent", "<e1>", "to", "RNA", "and", "C2712370#ent", "<e2>", "the", "splicing", "process", "in", "vitro"], "h": {"id": "C2347319", "name": "C2347319#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [17, 18]}}
{"token": ["We", "present", "an", "80", "year", "old", "hypertensive", "patient", "who", "presented", "as", "an", "emergency", "with", "sudden", "onset", "severe", "chest", "and", "C0004604#ent", "<e1>", "the", "suspicion", "of", "C0241868#ent", "<e2>", "acute", "coronary", "syndrome"], "h": {"id": "C0004604", "name": "C0004604#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0241868", "name": "C0241868#ent", "pos": [24, 25]}}
{"token": ["The", "dietary", "components", "seem", "to", "lead", "to", "a", "decrease", "in", "C0458219#ent", "<e1>", "include", "omega-3", "fatty", "acids", "fish", "oil", ",", "vitamin", "E", "and", "moderate", "amounts", "C0001962#ent", "<e2>", "."], "h": {"id": "C0458219", "name": "C0458219#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [24, 25]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "the", "PKA-anchoring", "protein", ",", "C1412313#ent", "<e1>", ",", "binds", "PP1c", "with", "a", "dissociation", "constant", "(", "C1705240#ent", "<e2>", ")", "of", "12.1", "+", "/-", "4", "nM", "in", "vitro"], "h": {"id": "C1412313", "name": "C1412313#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [19, 20]}}
{"token": ["Human", "mononuclear", "leukocytes", "C4049597#ent", "<e1>", ")", "respond", "to", "oxidative", "DNA", "damage", "activation", "of", "ADP", "ribosylation", "initiation", "of", "C1333237#ent", "<e2>", "synthesis", "(", "i.e.", "unscheduled", "DNA", "synthesis", "UDS", ")", ",", "whereas", "neutrophils", "do", "not", "."], "h": {"id": "C4049597", "name": "C4049597#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [17, 18]}}
{"token": ["Anaerobic", "growth", "reduced", "the", "C1334899#ent", "<e1>", "rate", "of", "rad27", ",", "C1332686#ent", "<e2>", ",", "and", "rad52", "mutants", "indicating", "a", "role", "of", "reactive", "oxygen", "species", "C1334899#ent", "<e1>", "formation", "in", "these", "mutants", "."], "h": {"id": "C1332686", "name": "C1332686#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [4, 5]}}
{"token": ["C0003451#ent", "<e1>", "to", "treat", "HIV", "infection", "closely", "associated", "with", "and", "C0023787#ent", "<e2>"], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023787", "name": "C0023787#ent", "pos": [10, 11]}}
{"token": ["Retroviral", "infection", "induces", "a", "shift", "from", "phospholipid", "to", "neutral", "fat", "synthesis", "host", "cells", "and", "a", "long", "C0003451#ent", "<e1>", ",", "i.e.", ",", "antiprotease", ",", "treatment", "may", "lead", "to", "C0023787#ent", "<e2>", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023787", "name": "C0023787#ent", "pos": [27, 28]}}
{"token": ["C1367714#ent", "<e1>", "is", "the", "first", "C0076951#ent", "<e2>", "be", "identified", "in", "nematodes", "and", ",", "because", "of", "its", "associated", "lethality", "and", "distinctive", "sequence", "properties", ",", "provides", "a", "new", "and", "attractive", "target", "for", "anti-parasitic", "drugs"], "h": {"id": "C1367714", "name": "C1367714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0076951", "name": "C0076951#ent", "pos": [5, 6]}}
{"token": ["CD300a/c", "triggering", "by", "cross-linking", "antibody", "reduced", "C1710304#ent", "<e1>", "and", "increased", "C1415900#ent", "<e2>", "secretion", "by", "pDCs", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [10, 11]}}
{"token": ["Clinical", "effects", "C0036516#ent", "<e1>", "were", "also", "unaltered", "by", "C0006863#ent", "<e2>", "pretreatment", "."], "h": {"id": "C0036516", "name": "C0036516#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006863", "name": "C0006863#ent", "pos": [8, 9]}}
{"token": ["We", "have", "investigated", "the", "C1539479#ent", "<e1>", "of", "the", "C1819716#ent", "<e2>", "cybrids", "derived", "from", "\"", "donor-recipient", "\"", "protoplast", "fusion", "X-irradiated", "Raphanus", "sativus", "(", "cms", "line", "and", "iodoacetamide-treated", "Brassica", "napus", "cv", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1819716", "name": "C1819716#ent", "pos": [8, 9]}}
{"token": ["When", "C.", "albicans", "grown", "in", "C0815040#ent", "<e1>", "the", "enzyme", "was", "detected", "exclusively", "in", "transformants", "C0907533#ent", "<e2>", "expressing", "SAP2", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}}
{"token": ["Different", "types", "of", "peripheral", "neuropathy", "myelopathy", "have", "been", "reported", "associated", "with", "HIV", "infection", "sensory", "symmetrical", "polyneuropathy", ",", "acute", "inflammatory", "demyelinating", "polyneuropathy", "chronic", "inflammatory", "demyelinating", "polyneuropathy", "C0740343#ent", "<e1>", "sensory", "ataxic", "neuropathy", "ganglioneuronitis", ")", ",", "cauda", "equina", "syndrome", "amyotrophic", "lateral", "sclerosis", "spastic", "paraparesia", "and", "C0442874#ent", "<e2>", "diagnosed", "by", "electrophysiologic", "study"], "h": {"id": "C0740343", "name": "C0740343#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [42, 43]}}
{"token": ["These", "mice", "did", "not", "develop", "an", "C1290884#ent", "<e1>", "for", "mice", "deficient", "in", "TGF-beta", "receptors", "I", "C3273406#ent", "<e2>", ",", "suggesting", "that", "the", "suppression", "of", "inflammation", "by", "TGF-beta", "is", "Smad4", "independent", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [15, 16]}}
{"token": ["Human", "RHBG", "resides", "at", "chromosome", "1q21.3", "which", "harbors", "candidate", "C1417679#ent", "<e1>", "for", "medullary", "cystic", "kidney", "disease", "whereas", "mouse", "C1422764#ent", "<e2>", "is", "syntenic", "on", "chromosome", "3"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422764", "name": "C1422764#ent", "pos": [18, 19]}}
{"token": ["C0125988#ent", "<e1>", "inhibited", "endogenous", "rat", "liver", "C3659502#ent", "<e2>", "in", "vitro", "the", "concentration", "range", "between", "10(-5", ")", "M", "and", "10(-6)M.", "C0125988#ent", "<e1>", "exerted", "little", "effect", "on", "hepatic", "aldehyde", "dehydrogenase", "in", "vitro"], "h": {"id": "C0125988", "name": "C0125988#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [6, 7]}}
{"token": ["The", "results", "suggest", "that", "C0125988#ent", "<e1>", "possesses", "depressant", "properties", "and", "inhibition", "of", "C3659502#ent", "<e2>", "underlie", "the", "observed", "behavioral", "response", "."], "h": {"id": "C0125988", "name": "C0125988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [12, 13]}}
{"token": ["On", "the", "contrary", ",", "C1366535#ent", "<e1>", "had", "little", "effect", "on", "SAPK", "(", "C0380051#ent", "<e2>", "c-Jun", "N-terminal", "kinase", "phosphorylation", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [12, 13]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "investigate", "the", "effects", "of", "C1334081#ent", "<e1>", "with", "and", "without", "pre-treatment", "with", "the", "NO", "synthase", "C0068821#ent", "<e2>", "L-NAME", ")", "on", "local", "brain", "tissue", "oxygenation", "in", "a", "beating", "heart", "model"], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0068821", "name": "C0068821#ent", "pos": [21, 22]}}
{"token": ["Systolic", "blood", "pressure", "severity", "of", "C1565489#ent", "<e1>", "related", "to", "mitral", "regurgitation", "LVH", "in", "subjects", "with", "C1418599#ent", "<e2>", "."], "h": {"id": "C1565489", "name": "C1565489#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418599", "name": "C1418599#ent", "pos": [15, 16]}}
{"token": ["Since", "C1334089#ent", "<e1>", "or", "insulin", "have", "been", "suggested", "to", "affect", "C1565427#ent", "<e2>", "phosphorylation", ",", "we", "analyzed", "the", "role", "of", "C1565427#ent", "<e2>", "in", "IGF-I-", "or", "insulin-induced", "MAP", "kinase", "activation", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [10, 11]}}
{"token": ["C0022251#ent", "<e1>", "dinitrate", "had", "no", "haemodynamic", "effects", "normal", "and", "cirrhotic", "rats", "treated", "with", "C0062637#ent", "<e2>", "."], "h": {"id": "C0022251", "name": "C0022251#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0062637", "name": "C0062637#ent", "pos": [13, 14]}}
{"token": ["The", "outcome", "was", "satisfactory", "in", "all", "patients", ",", "except", "for", "one", "patient", "who", "underwent", "clipping", "of", "a", "C0751001#ent", "<e1>", "suffered", "a", "thalamic", "and", "C0751955#ent", "<e2>"], "h": {"id": "C0751001", "name": "C0751001#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0751955", "name": "C0751955#ent", "pos": [23, 24]}}
{"token": ["Marker", "transmission", "ratio", "distortion", "(", "C0524893#ent", "<e1>", ")", "in", "genetic", "mapping", "is", "frequently", "ascribed", "to", "selection", "against", "C0002085#ent", "<e2>", "combinations", "that", "cause", "hybrid", "incompatibility", "."], "h": {"id": "C0524893", "name": "C0524893#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [17, 18]}}
{"token": ["An", "inflammatory", "reaction", "induced", "by", "lipopolysaccharide", "(", "C0175697#ent", "<e1>", ")", "injection", "into", "the", "air-pouch", ",", "and", "the", "time", "course", "C4085202#ent", "<e2>", "activity", "in", "the", "exudate", "was", "investigated", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4085202", "name": "C4085202#ent", "pos": [19, 20]}}
{"token": ["The", "MTRR", "gene", "codes", "C0672719#ent", "<e1>", "one", "of", "the", "C3540790#ent", "<e2>", "involved", "in", "the", "conversion", "of", "homocysteine", "to", "methionine", "."], "h": {"id": "C0672719", "name": "C0672719#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [9, 10]}}
{"token": ["C0672719#ent", "<e1>", "MTRR", ")", "and", "betaine-homocysteine", "S-methyltransferase", "BHMT", ")", "are", "two", "C3540790#ent", "<e2>", "that", "regulate", "homocysteine", "metabolism"], "h": {"id": "C0672719", "name": "C0672719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["PI", "breakdown", "by", "C0001640#ent", "<e1>", "NaF", "was", "attenuated", "by", "N-ethylmaleimide", "but", "not", "C0043167#ent", "<e2>", "toxin", "treatment", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [12, 13]}}
{"token": ["The", "promitogenic", "responses", "to", "C0001640#ent", "<e1>", "activation", "were", "blocked", "by", "C0043167#ent", "<e2>", "PT", ";", "100", "ng/ml", ")", ",", "which", "ADP-ribosylates", "G", "protein", "coupled", "to", "adenylate", "cyclase", "activation", "."], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [10, 11]}}
{"token": ["C0684275#ent", "<e1>", "is", "a", "rare", ",", "C0852077#ent", "<e2>", "which", "blood", "clotting", "impaired", "such", "that", "patients", "suffer", "from", "excessive", "internal", "and", "external", "bleeding", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0852077", "name": "C0852077#ent", "pos": [6, 7]}}
{"token": ["In", "CHO-SR1", ",", "the", "rank", "of", "potency", "of", "C2987634#ent", "<e1>", "affecting", "adenyl", "cyclase", "SRIF-14", "=", "SRIF-28", ">", "RC", "160", ">", "C1419249#ent", "<e2>", "201", "-", "995", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419249", "name": "C1419249#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "whether", "C2698196#ent", "<e1>", "(", "ATV", ")", "and", "C0071097#ent", "<e2>", "(", "PIO", ")", "increase", "the", "myocardial", "content", "of", "lipoxin-A4", "and", "15(R)-epi-lipoxin-A4", "(", "15-epi-LXA4", ")", ",", "both", "arachidonic", "acid", "products", "strong", "antiinflammatory", "properties"], "h": {"id": "C2698196", "name": "C2698196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0071097", "name": "C0071097#ent", "pos": [9, 10]}}
{"token": ["Lysophosphatidylserine", "(", "C2697656#ent", "<e1>", ")", "was", "found", "to", "stimulate", "intracellular", "calcium", "increase", "in", "C1822629#ent", "<e2>", "human", "glioma", "cells"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1822629", "name": "C1822629#ent", "pos": [13, 14]}}
{"token": ["Of", "the", "14", "C2681564#ent", "<e1>", "biopsies", "with", "FC", ",", "13", "showed", "superimposed", "C0220769#ent", "<e2>", "."], "h": {"id": "C2681564", "name": "C2681564#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0220769", "name": "C0220769#ent", "pos": [12, 13]}}
{"token": ["Patients", "in", "intensive", "care", "units", "suffer", "C0151786#ent", "<e1>", "atrophy", "due", "to", "C0393851#ent", "<e2>", "CIP", ")", ",", "an", "axonal", "neuropathy", "associated", "with", "systemic", "inflammatory", "response", "syndrome", "multiple", "organ", "failure"], "h": {"id": "C0151786", "name": "C0151786#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0393851", "name": "C0393851#ent", "pos": [11, 12]}}
{"token": ["Inhibitor", "studies", "with", "PD98059", "and", "C0075193#ent", "<e1>", "showed", "that", "a", "C0169101#ent", "<e2>", "the", "oxidative", "response", "while", "the", "antioxidant", "signal", "transmitted", "by", "a", "serine/threonine", "kinase"], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "we", "show", "that", "TAK1", ",", "a", "TGF-beta-activated", "protein", "kinase", "stimulates", "ER81", "via", "the", "C1120843#ent", "<e1>", "thereby", "induces", "the", "C1334470#ent", "<e2>", "promoter", "."], "h": {"id": "C1120843", "name": "C1120843#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334470", "name": "C1334470#ent", "pos": [20, 21]}}
{"token": ["Patients", "with", "C0009447#ent", "<e1>", "previously", "been", "thought", "not", "to", "be", "more", "susceptible", "to", "C0036117#ent", "<e2>", "a", "combination", "of", "low", "gastric", "acidity", "and", "impaired", "humoral", "immunity", "predispose", "them", "to", "such", "infection", "."], "h": {"id": "C0009447", "name": "C0009447#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [13, 14]}}
{"token": ["The", "site", "of", "phosphorylation", "was", "indicated", "by", "C0033993#ent", "<e1>", "confirmed", "using", "a", "mutant", "recombinant", "C1335590#ent", "<e2>", "lacking", "the", "relevant", "serine", "(", "serine-180", ")", "."], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335590", "name": "C1335590#ent", "pos": [14, 15]}}
{"token": ["There", "are", "C0003028#ent", "<e1>", "various", "autonomic", "dysfunctions", "as", "C0040416#ent", "<e2>", "eating", "and", "swallowing", "difficulties", "constipation", ",", "episodic", "fever", "profound", "hypotonia", "and", "episodes", "of", "apnea", "."], "h": {"id": "C0003028", "name": "C0003028#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040416", "name": "C0040416#ent", "pos": [8, 9]}}
{"token": ["Binding", "of", "the", "cytidylyltransferase", "to", "egg", "PC", "vesicles", "containing", "C0028928#ent", "<e1>", "monoolein", ",", "oleoylacetylglycerol", "or", "C0041073#ent", "<e2>", "resulted", "in", "enzyme", "activation", ",", "as", "did", "binding", "to", "dipalmitoylPC-oleic", "acid", "vesicles", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041073", "name": "C0041073#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "our", "findings", "point", "that", "glomerular", "inflammation", "lupus", "and", "non-lupus", "membranous", "glomerulopathy", "different", "signalling", "pathways", "suggest", "that", "in", "C0024143#ent", "<e1>", "COX-2", "and", "monocytes/", "macrophages", "not", "COX-1", "C0597298#ent", "<e2>", "are", "involved", "in", "the", "inflammatory", "process"], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [28, 29]}}
{"token": ["Several", "recent", "reports", "highlight", "the", "importance", "of", "modifying", "factors", "in", "determining", "the", "risk", "for", "cancer", "of", "a", "person", "carrying", "a", "mutant", "C1706112#ent", "<e1>", "of", "a", "C0919453#ent", "<e2>"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0919453", "name": "C0919453#ent", "pos": [25, 26]}}
{"token": ["Using", "a", "biochemical", "purification", ",", "we", "have", "identified", "the", "C4049596#ent", "<e1>", "a", "mammalian", "homologue", "of", "avian", "MafA/L-Maf", "(", "C4084710#ent", "<e2>", ")", "."], "h": {"id": "C4049596", "name": "C4049596#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4084710", "name": "C4084710#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "other", "C0174045#ent", "<e1>", "such", "as", "C0073186#ent", "<e2>", ",", "RHOD", ",", "and", "their", "effectors", "(", "DIAPH1", "and", "DIAPH2", ")", ",", "may", "modulate", "PKN1/", "ROCK1", "signaling", "to", "effect", "changes", "in", "myosin", "phosphatase", "activity", "myosin", "light", "chain", "phosphorylation"], "h": {"id": "C0174045", "name": "C0174045#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073186", "name": "C0073186#ent", "pos": [7, 8]}}
{"token": ["Neither", "C0717550#ent", "<e1>", "cilexetil", "nor", "enalapril", "affected", "C0003402#ent", "<e2>", "renal", "tissue", "nephrectomized", "rats", ",", "indicating", "that", "mechanisms", "other", "than", "alteration", "in", "oxidative", "stress", "involved", "in", "the", "renoprotective", "effects", "of", "C0717550#ent", "<e1>", "cilexetil", "and", "enalapril", "."], "h": {"id": "C0717550", "name": "C0717550#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [7, 8]}}
{"token": ["Trials", "with", "newer", "antihypertensive", "classes", "revealed", "superior", "effects", "on", "outcomes", "associated", "with", "C0919438#ent", "<e1>", ",", "and", "that", "alpha-blockers", "are", "less", "C0007209#ent", "<e2>", "than", "diuretics", "."], "h": {"id": "C0919438", "name": "C0919438#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [20, 21]}}
{"token": ["A", "procedure", "to", "immunoaffinity", "purify", "the", "human", "transcription", "factor", "IIH", "C1415344#ent", "<e1>", ")", "was", "developed", "using", "a", "monoclonal", "antibody", "recognizes", "an", "epitope", "in", "ERCC3", "(", "C0268136#ent", "<e2>", ")", ",", "the", "largest", "subunit", "of", "C1415344#ent", "<e1>", "."], "h": {"id": "C0268136", "name": "C0268136#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1415344", "name": "C1415344#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "C1419366#ent", "<e1>", "deficient", "brain", "showed", "the", "increased", "C1706439#ent", "<e2>", "myeloperoxidase", "(", "MPO", ")", "activity", "in", "the", "brain", ",", "supporting", "the", "putative", "anti-oxidative", "action", "of", "C1419366#ent", "<e1>", "."], "h": {"id": "C1419366", "name": "C1419366#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706439", "name": "C1706439#ent", "pos": [9, 10]}}
{"token": ["Occidental", "type", "cerebromuscular", "dystrophy", "(", "C3150833#ent", "<e1>", ")", "forms", "a", "substantial", "distinct", "group", "within", "congenital", "muscular", "dystrophy", "C2827469#ent", "<e2>", ")", "."], "h": {"id": "C3150833", "name": "C3150833#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2827469", "name": "C2827469#ent", "pos": [17, 18]}}
{"token": ["All", "experimental", "results", "this", "study", "are", "described", "in", "terms", "of", "packing", "density", "for", "C0720930#ent", "<e1>", "counterions", "in", "the", "C1416870#ent", "<e2>", "."], "h": {"id": "C0720930", "name": "C0720930#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416870", "name": "C1416870#ent", "pos": [18, 19]}}
{"token": ["We", "now", "report", "that", "arteries", "from", "a", "primate", "model", "C0004153#ent", "<e1>", "with", "dietary-induced", "hypercholesterolemia", "increased", "levels", "of", "C1705079#ent", "<e2>", "mRNA", "expression", "in", "vivo", "whereas", "their", "normal", "counterparts", "demonstrate", "minimal", "C1705079#ent", "<e2>", "expression", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [9, 10]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705079", "name": "C1705079#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "detailed", "and", "systematic", "studies", "have", "been", "started", "in", "order", "to", "understand", "the", "rheological", "characteristics", "of", "human", "red", "blood", "cells", "RBCs", ")", ",", "C0633225#ent", "<e1>", "other", "antioxidant", "parameters", "in", "clinically", "serious", "C0001339#ent", "<e2>"], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [32, 33]}}
{"token": ["This", "group", "consisted", "of", "65", "patients", "with", "otitic", "meningitis", "four", "with", "otitic", "brain", "abscess", "four", "with", "C0020255#ent", "<e1>", "three", "with", "C0037198#ent", "<e2>", "three", "with", "otitic", "subdural", "empyemas", "and", "five", "with", "an", "otitic", "subdural", "effusion", "fluid", "."], "h": {"id": "C0020255", "name": "C0020255#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0037198", "name": "C0037198#ent", "pos": [20, 21]}}
{"token": ["Continuing", "pain", "after", "surgery", "is", "due", "to", "C0394016#ent", "<e1>", "in", "both", "the", "peripheral", "nervous", "system", "C0020429#ent", "<e2>", ")", "and", "the", "central", "nervous", "system", "hyperexcitability", ")", "."], "h": {"id": "C0394016", "name": "C0394016#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [15, 16]}}
{"token": ["C0394016#ent", "<e1>", "lidocaine", "reduced", "primary", "and", "secondary", "C0020429#ent", "<e2>", "that", "had", "fully", "developed", "."], "h": {"id": "C0394016", "name": "C0394016#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [7, 8]}}
{"token": ["We", "tested", "whether", "low", "doses", "local", "anesthetics", "pre-", "or", "C0394016#ent", "<e1>", "can", "reduce", "heat", "trauma-induced", "primary", "and", "secondary", "C0020429#ent", "<e2>", "in", "humans", "."], "h": {"id": "C0394016", "name": "C0394016#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [18, 19]}}
{"token": ["The", "result", "showed", "that", "complexing", "C0031957#ent", "<e1>", "and", "imidazole", "into", "pyropheophorbide-a", "decreases", "its", "dark", "toxicity", "greatly", "decreasing", "C0162830#ent", "<e2>", "and", ",", "enhances", "its", "C0162830#ent", "<e2>", "without", "greatly", "increasing", "dark", "toxicity", "respectively", "."], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162830", "name": "C0162830#ent", "pos": [17, 18]}}
{"token": ["It", "has", "been", "demonstrated", "that", "C4049859#ent", "<e1>", "can", "be", "modulated", "by", "several", "C0018799#ent", "<e2>", "the", "autonomic", "nervous", "system", "even", "drugs", "with", "purportedly", "no", "antiarrhythmic", "properties", "."], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [12, 13]}}
{"token": ["In", "the", "present", "C0003211#ent", "<e1>", "anti-oxidative", "drugs", "and", "C2936882#ent", "<e2>", "are", "under", "investigation", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [8, 9]}}
{"token": ["C0264511#ent", "<e1>", "IIP", ")", "is", "a", "heterogeneous", "group", "diseases", "comprising", "acute", "interstitial", "pneumonia", "C0006272#ent", "<e2>", "pneumonia", "(", "BOOP", ")", ",", "nonspecific", "interstitial", "pneumonia", "desquamative", "interstitial", "pneumonia", "and", "idiopathic", "pulmonary", "fibrosis", "usual", "interstitial", "pneumonia", "IPF/UIP", ")", "."], "h": {"id": "C0264511", "name": "C0264511#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006272", "name": "C0006272#ent", "pos": [13, 14]}}
{"token": ["Certain", "inborn", "errors", "metabolism", "that", "result", "in", "C0023895#ent", "<e1>", "including", "galactosemia", ",", "hepatorenal", "tyrosinemia", "hereditary", "fructose", "intolerance", ",", "and", "C0019202#ent", "<e2>", "have", "specific", "nutritional", "requirements"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [19, 20]}}
{"token": ["The", "differential", "diagnoses", "hepatic", ",", "renal", ",", "hypoxic-ischemic", "or", "C0085584#ent", "<e1>", "well", "as", "encephalopathies", ",", "C0025517#ent", "<e2>", "organ", "dysfunctions", "other", "origin", "."], "h": {"id": "C0085584", "name": "C0085584#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [15, 16]}}
{"token": ["In", "order", "to", "deliver", "anthracyclines", "to", "transferrin", "(", "TRF", ")", "receptors", "on", "the", "plasma", "membranes", "human", "tumor", "cells", "we", "have", "prepared", "conjugates", "of", "C0014582#ent", "<e1>", "(", "ADR", ")", "with", "human", "C1334121#ent", "<e2>", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1334121", "name": "C1334121#ent", "pos": [30, 31]}}
{"token": ["Late", "infantile", "neuronal", "ceroid", "lipofuscinosis", "C0268281#ent", "<e1>", ")", "is", "one", "of", "the", "most", "common", "pediatric", "C1285162#ent", "<e2>"], "h": {"id": "C0268281", "name": "C0268281#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "C1565830#ent", "<e1>", "and", "IL-1beta", "converting", "C1333402#ent", "<e2>", "mRNA", "levels", "remained", "unchanged", "."], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", "to", "our", "previous", "data", "on", "fresh", "C0669372#ent", "<e1>", ",", "PT", "had", "no", "effect", "the", "EGF-induced", "tyrosine", "phosphorylation", "C0662760#ent", "<e2>", ",", "although", "Ins-1,4,5-P3", "and", "diacylglycerol", "production", "inhibited", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0662760", "name": "C0662760#ent", "pos": [19, 20]}}
{"token": ["We", "studied", "and", "quantified", "the", "effect", "of", "C0010592#ent", "<e1>", "A", "on", "hepatic", "F-actin", "bile", "canalicular", "basolateral", "membranes", "rats", "C0342895#ent", "<e2>", "either", "soybean", "lecithin", "triacylglycerol-enriched", "diet", ",", "or", "low-fat", "diet", "means", "of", "confocal", "laser", "scanning", "microscopy", "imaging"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [18, 19]}}
{"token": ["Glycosylphosphatidylinositols", "(", "GPIs", ")", "serve", "as", "membrane", "anchors", "C0032594#ent", "<e1>", "and", "proteins", "in", "the", "C0162572#ent", "<e2>", "parasite", "Leishmania", "major"], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162572", "name": "C0162572#ent", "pos": [14, 15]}}
{"token": ["However", ",", "although", "C0020261#ent", "<e1>", "depressed", "urinary", "in", "rats", "consuming", "sodium", "bicarbonate", "rats", "receiving", "equimolar", "supplements", "of", "C0071751#ent", "<e2>", "not", "lower", "urinary", "calcium", "given", "C0020261#ent", "<e1>", ",", "despite", "evidence", "of", "the", "expected", "thiazide-mediated", "diuresis", "."], "h": {"id": "C0071751", "name": "C0071751#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [3, 4]}}
{"token": ["Cimetidine", "has", "been", "shown", "not", "to", "alter", "the", "pharmacokinetics", "of", "C0024002#ent", "<e1>", "or", "oxazepam", "when", "administered", "concurrently", "with", "either", "of", "these", "C0005064#ent", "<e2>", "."], "h": {"id": "C0024002", "name": "C0024002#ent", "pos": [10, 11]}, "relation": "has_structural_class", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [21, 22]}}
{"token": ["We", "observed", "that", "C0001457#ent", "<e1>", "C0017356#ent", "<e2>", ",", "the", "HIV-1", "vector", "expressing", "C0017356#ent", "<e2>", ",", "and", "SNV-Nef", "were", "able", "to", "induce", "apoptosis", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0001457", "name": "C0001457#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017356", "name": "C0017356#ent", "pos": [5, 6]}}
{"token": ["If", "potent", "diuretics", "are", "without", "effect", ",", "the", "C0018801#ent", "<e1>", "be", "treated", "more", "vigorously", "or", "a", "combination", "with", "C0008273#ent", "<e2>", "tried", "out", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0008273", "name": "C0008273#ent", "pos": [18, 19]}}
{"token": ["In", "vitro", "many", "C0252684#ent", "<e1>", "been", "shown", "to", "have", "C0073438#ent", "<e2>", "ATP-dependent", "RNA", "helicase", "activities", "."], "h": {"id": "C0252684", "name": "C0252684#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073438", "name": "C0073438#ent", "pos": [9, 10]}}
{"token": ["Less", "common", "presenting", "symptoms", "include", "chronic", "cough", "C0747651#ent", "<e1>", "failure", "to", "thrive", ",", "dyspnea", ",", "C0011168#ent", "<e2>", ",", "or", "acute", "respiratory", "distress", "especially", "in", "infants", "with", "an", "upper", "respiratory", "tract", "infection"], "h": {"id": "C0747651", "name": "C0747651#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [15, 16]}}
{"token": ["C1706110#ent", "<e1>", ",", "the", "rat", "C1334043#ent", "<e2>", "of", "a", "gene", "(", "LIN-2", ")", "required", "for", "vulval", "differentiation", "Caenorhabditis", "elegans", "is", "expressed", "in", "mammalian", "brain", ",", "but", "its", "function", "in", "neurons", "is", "unknown", "."], "h": {"id": "C1706110", "name": "C1706110#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}}
{"token": ["Antibodies", "to", "C0030956#ent", "<e1>", "115", "-", "129", "formed", "precipitating", "C0751283#ent", "<e2>", "gel", "immunodiffusion", "demonstrating", "the", "oligomeric", "state", "of", "myotoxin", "II", "not", "only", "in", "its", "crystalline", "structure", "dimeric", ")", ",", "but", "also", "in", "solution", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751283", "name": "C0751283#ent", "pos": [9, 10]}}
{"token": ["The", "rats", "were", "treated", "with", "C0004057#ent", "<e1>", "for", "5", "weeks", "as", "in", "the", "treatment", "of", "C0035436#ent", "<e2>", "children", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0035436", "name": "C0035436#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "C1336575#ent", "<e1>", "variants", "had", "different", "binding", "affinities", "to", "two", "cytoplasmic", "proteins", "C0971654#ent", "<e2>", "receptor", "type", "f", "polypeptide", "PTPRF", ")", ",", "interacting", "protein", "liprin", ")", ",", "alpha1", ",", "and", "G3BP2a", "."], "h": {"id": "C1336575", "name": "C1336575#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0971654", "name": "C0971654#ent", "pos": [14, 15]}}
{"token": ["Overexpression", "of", "C1415845#ent", "<e1>", "PCMTase", ")", ",", "the", "enzyme", "that", "methylates", "C0525678#ent", "<e2>", ",", "had", "little", "effect", "on", "basal", "transport", "enhanced", "aldosterone-stimulated", "transport", "in", "A6", "cells", "."], "h": {"id": "C1415845", "name": "C1415845#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [11, 12]}}
{"token": ["A", "similar", "release", "of", "C1418973#ent", "<e1>", "was", "observed", "after", "hormonal", "stimulation", "three", "patients", "with", "C0400979#ent", "<e2>", "in", "four", "patients", "with", "pancreatic", "exocrine", "insufficiency"], "h": {"id": "C1418973", "name": "C1418973#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0400979", "name": "C0400979#ent", "pos": [14, 15]}}
{"token": ["A", "serum", "antibody", "C0007034#ent", "<e1>", "been", "reported", "in", "patients", "with", "C1527336#ent", "<e2>", "idiopathic", "chronic", "pancreatitis"], "h": {"id": "C0007034", "name": "C0007034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [10, 11]}}
{"token": ["Furthermore", "atropine", "antagonized", "the", "C4048158#ent", "<e1>", "caused", "by", "intoxication", "with", "C3540559#ent", "<e2>", "."], "h": {"id": "C4048158", "name": "C4048158#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540559", "name": "C3540559#ent", "pos": [10, 11]}}
{"token": ["This", "study", "investigated", "possible", "correlations", "of", "intra-tumoral", "LATS1", "and", "C0913413#ent", "<e1>", "mRNA", "levels", "with", "response", "to", "epirubicin", "plus", "C0010583#ent", "<e2>", "(", "EC", ")", "or", "docetaxel", "(", "DOC", ")", "treatment", "."], "h": {"id": "C0913413", "name": "C0913413#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [18, 19]}}
{"token": ["C0001529#ent", "<e1>", "a", "rare", "C0037277#ent", "<e2>", "characterised", "by", "an", "early", "onset", "eruption", "associated", "with", "multiple", "truncal", "keratotic", "lesions", "."], "h": {"id": "C0001529", "name": "C0001529#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [4, 5]}}
{"token": ["C0477611#ent", "<e1>", "previously", "known", "as", "Scheuermann's", "disease", "C0029420#ent", "<e2>", "is", "common", "and", "is", "probably", "becoming", "increasingly", "prevalent", "."], "h": {"id": "C0477611", "name": "C0477611#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029420", "name": "C0029420#ent", "pos": [7, 8]}}
{"token": ["Instead", ",", "both", "C0014442#ent", "<e1>", "can", "transfer", "sulfate", "the", "4-position", "of", "C1825858#ent", "<e2>", "in", "the", "context", "of", "GalNAc", "beta", "1", "->4GlcNAc", "beta", "1", "->R", "attached", "to", "both", "N-linked", "and", "core", "2", "branched", "O-linked", "oligosaccharides", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1825858", "name": "C1825858#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "a", "case", "of", "C0026916#ent", "<e1>", "MAC", ")", "osteomyelitis", "and", "C0003869#ent", "<e2>", "an", "immunocompetent", "man", "."], "h": {"id": "C0026916", "name": "C0026916#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003869", "name": "C0003869#ent", "pos": [11, 12]}}
{"token": ["In", "X-linked", "agammaglobulinemia", "molecular", "defect", "found", "to", "reside", "in", "the", "gene", "encoding", "a", "novel", "cytoplasmic", "tyrosine", "kinase", "C1528376#ent", "<e1>", ",", "atk", ",", "or", "C1412841#ent", "<e2>", ")", "expressed", "by", "B", "and", "myeloid", "cells"], "h": {"id": "C1528376", "name": "C1528376#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412841", "name": "C1412841#ent", "pos": [23, 24]}}
{"token": ["The", "infection", "almost", "always", "remains", "asymptomatic", "but", "is", "also", "associated", "with", "distinct", "diseases", ":", "tropical", "spastic", "paraparesis", "C1710292#ent", "<e1>", ")", ",", "and", "adult", "T-cell", "leukemia", "C1332807#ent", "<e2>", ")", "."], "h": {"id": "C1710292", "name": "C1710292#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [25, 26]}}
{"token": ["To", "confirm", "that", "aspirin", "suppositories", "an", "effective", "treatment", "for", "C0948008#ent", "<e1>", "we", "examined", "the", "suppressive", "effects", "of", "200-mg", "C0004057#ent", "<e2>", "suppositories", "on", "platelet", "aggregation"], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [18, 19]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "effect", "of", "C2936882#ent", "<e1>", "and", "progesterone", "on", "the", "generation", "of", "C0042397#ent", "<e2>", "superoxide", "anion", "O2(-", ")", ")", "by", "microvessels", "from", "SHR", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [19, 20]}}
{"token": ["The", "present", "studies", "assessed", "the", "contribution", "of", "various", "CYP2C", "and", "CYP3A4", "C3540790#ent", "<e1>", "to", "C0338271#ent", "<e2>", "metabolism", "by", "using", "recombinant", "human", "C3540790#ent", "<e1>", "."], "h": {"id": "C0338271", "name": "C0338271#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["Comparison", "of", "the", "C1412821#ent", "<e1>", "the", "known", "C0053653#ent", "<e2>", "and", "recognition", "of", "the", "expressed", "protein", "encoded", "by", "this", "cDNA", "by", "monoclonal", "antibodies", "against", "purified", "biotinidase", "demonstrated", "the", "identity", "of", "this", "cDNA", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0053653", "name": "C0053653#ent", "pos": [7, 8]}}
{"token": ["We", "report", "on", "two", "brothers", "with", "achalasia", ",", "C0405580#ent", "<e1>", "alacrima", ",", "short", "stature", "microcephaly", ",", "ataxia", ",", "C0338508#ent", "<e2>", "and", "developmental", "delay"], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0338508", "name": "C0338508#ent", "pos": [18, 19]}}
{"token": ["The", "presence", "of", "achalasia", "with", "dysphagia", ",", "C0405580#ent", "<e1>", "reduced", "tear", "production", ",", "C0338508#ent", "<e2>", "peripheral", "motor-sensory", "neuropathy", "axonal", "loss", "us", "to", "clinically", "diagnose", "Allgrove", "syndrome", "though", "a", "genetic", "study", "no", "mutations", "in", "the", "ALADIN", "gene", "exons"], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0338508", "name": "C0338508#ent", "pos": [13, 14]}}
{"token": ["Severe", "C0002878#ent", "<e1>", "haemoglobin", "4.4", "g/dl", ")", "was", "treated", "with", "C3540778#ent", "<e2>", ",", "massive", "blood", "transfusions", "splenectomy", ",", "at", "first", "without", "success", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540778", "name": "C3540778#ent", "pos": [10, 11]}}
{"token": ["We", "also", "found", "that", "agonistic", "antibodies", "specific", "for", "either", "C1363984#ent", "<e1>", "or", "TNFR2", "stimulated", "IL-6", "and", "RANTES", "secretion", "and", "activated", "C1366876#ent", "<e2>", "and", "p42/44", "MAPKs", "."], "h": {"id": "C1363984", "name": "C1363984#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [20, 21]}}
{"token": ["The", "serum", "levels", "HGF", "were", "not", "elevated", "in", "patients", "with", "IgA", "nephropathy", "IgAN", ")", ",", "Henoch-Sch\u00f6nlein", "purpura", "nephritis", "HSPN", ")", ",", "C0268743#ent", "<e1>", "MPGN", ")", ",", "poststreptococcal", "acute", "glomerulonephritis", "PSAGN", ")", ",", "C1827184#ent", "<e2>", "unilateral", "nephrectomy", "or", "proximal", "tubular", "dysfunction"], "h": {"id": "C0268743", "name": "C0268743#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1827184", "name": "C1827184#ent", "pos": [32, 33]}}
{"token": ["Fear", "of", "inducing", "C4025163#ent", "<e1>", "one", "reason", "why", "C3539185#ent", "<e2>", "are", "withheld", "in", "patients", "with", "rheumatoid", "arthritis", "RA", ")", "."], "h": {"id": "C4025163", "name": "C4025163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539185", "name": "C3539185#ent", "pos": [8, 9]}}
{"token": ["The", "work", "brings", "to", "the", "fore", "the", "role", "of", "the", "nature", "and", "composition", "of", "solvent-exposed", "residues", "in", "the", "adaptation", "of", "C3541394#ent", "<e1>", "to", "polyextreme", "conditions", ",", "as", "in", "C1970208#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1970208", "name": "C1970208#ent", "pos": [28, 29]}}
{"token": ["Treatments", "with", "C1335237#ent", "<e1>", "extract", "showed", "decreased", "levels", "of", "C1705323#ent", "<e2>", ",", "c-MYC", "and", "cyclin", "D1", "proteins", "aid", "cell", "proliferation", "by", "regulating", "beta-catenin", "by", "maintaining", "expression", "of", "APC", "and", "decreasing", "inactivation", "of", "GSK3beta", "."], "h": {"id": "C1335237", "name": "C1335237#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [9, 10]}}
{"token": ["These", "are", "the", "first", "endogenous", "C0017337#ent", "<e1>", "to", "be", "identified", "as", "up-regulated", "in", "programmed", "cell", "death", "C1414101#ent", "<e2>", ")", "in", "unicellular", "organisms"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414101", "name": "C1414101#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "C1705783#ent", "<e1>", "on", "alpha-subunit", "gene", "transcription", "mimicked", "by", "C0917964#ent", "<e2>", ",", "and", "both", "C1705783#ent", "<e1>", "and", "C0917964#ent", "<e2>", "increased", "the", "levels", "of", "intracellular", "cAMP", "."], "h": {"id": "C1705783", "name": "C1705783#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0917964", "name": "C0917964#ent", "pos": [11, 12]}}
{"token": ["C1622105#ent", "<e1>", "concentrations", "directly", "and", "inversely", "correlated", "with", "C1421531#ent", "<e2>", "activity", "but", "not", "with", "GSH", "level", "."], "h": {"id": "C1622105", "name": "C1622105#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [8, 9]}}
{"token": ["In", "this", "study", ",", "biological", "functions", "BDNF", "and", "NT-3", "in", "the", "chick", "vestibular", "and", "C0085648#ent", "<e1>", "development", "was", "assessed", "in", "vitro", "compared", "to", "those", "of", "other", "C1522444#ent", "<e2>"], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1522444", "name": "C1522444#ent", "pos": [26, 27]}}
{"token": ["The", "oleanane", "triterpenoid", "2-cyano-3,12-dioxoolean-1,9-dien-28-oic", "acid", "C0762434#ent", "<e1>", ")", "is", "a", "multifunctional", "molecule", "induces", "C0021345#ent", "<e2>", "differentiation", "of", "human", "myeloid", "leukemia", "cells", "inhibits", "proliferation", "of", "diverse", "human", "tumor", "cell", "lines"], "h": {"id": "C0762434", "name": "C0762434#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [13, 14]}}
{"token": ["The", "PC", "showed", "immunoreactivity", "for", "C1420709#ent", "<e1>", ",", "and", "both", "PC", "and", "C3274837#ent", "<e2>", "foci", "were", "positive", "for", "high-molecular-weight", "keratins"], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3274837", "name": "C3274837#ent", "pos": [12, 13]}}
{"token": ["5-Amino", "C1742019#ent", "<e1>", "preparations", "are", "used", "in", "therapy", "for", "patients", "with", "C0021390#ent", "<e2>"], "h": {"id": "C1742019", "name": "C1742019#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [11, 12]}}
{"token": ["Mutual", "azo", "prodrug", "of", "5-aminosalicylic", "acid", "l-tyrosine", "was", "synthesized", "by", "coupling", "l-tyrosine", "C1742019#ent", "<e1>", "for", "targeted", "drug", "delivery", "the", "inflamed", "gut", "tissue", "C0021390#ent", "<e2>"], "h": {"id": "C1742019", "name": "C1742019#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [22, 23]}}
{"token": ["Dogs", "with", "inducible", "VT", "or", "C0042510#ent", "<e1>", "underwent", "drug", "studies", "timolol", "and", "C0033497#ent", "<e2>", ";", "the", "sequence", "of", "drug", "administration", "randomized", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [12, 13]}}
{"token": ["Cytomegalovirus", "(", "CMV", ")", "infections", "in", "patients", "with", "acquired", "immunodeficiency", "syndrome", "common", "and", "may", "present", "as", "C0035333#ent", "<e1>", ",", "encephalitis", ",", "esophagitis", ",", "gastritis", ",", "C0014356#ent", "<e2>", ",", "adrenalitis", ",", "or", "pneumonitis", "."], "h": {"id": "C0035333", "name": "C0035333#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014356", "name": "C0014356#ent", "pos": [25, 26]}}
{"token": ["Of", "particular", "interest", "is", "the", "association", "with", "C0020615#ent", "<e1>", ",", "which", "has", "implications", "for", "C0011849#ent", "<e2>"], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}}
{"token": ["Diabetes", "associated", "with", "severe", "C0020615#ent", "<e1>", "or", "extreme", "lability", ",", "despite", "optimization", "of", "C0011849#ent", "<e2>", "management", ",", "may", "benefit", "from", "either", "pancreas", "or", "islet", "transplant", "with", "the", "latter", "being", "the", "lower-risk", "procedure", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [13, 14]}}
{"token": ["C1414059#ent", "<e1>", "decreased", "cyclic", "AMP-stimulated", "C1413858#ent", "<e2>", "."], "h": {"id": "C1414059", "name": "C1414059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413858", "name": "C1413858#ent", "pos": [5, 6]}}
{"token": ["Two", "different", "forms", "of", "C1870389#ent", "<e1>", "thioredoxin", ")", "arising", "from", "the", "same", "C0017337#ent", "<e2>", "on", "a", "multicopy", "plasmid", "in", "an", "Escherichia", "coli", "expression", "system", "been", "isolated", "and", "characterized", "."], "h": {"id": "C1870389", "name": "C1870389#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["DA", "rats", "develop", "transient", "arthritis", "subcutaneous", "immunization", "adjuvant-oil", ",", "while", "chronic", "arthritis", "collagen", "autoreactivity", "when", "C0009325#ent", "<e1>", "is", "added", "to", "the", "C3541397#ent", "<e2>", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3541397", "name": "C3541397#ent", "pos": [21, 22]}}
{"token": ["ROMK", "protein", "expression", "was", "absent", "in", "TAL", "and", "C0008928#ent", "<e1>", "from", "null", "mice", "exhibited", "normal", "abundance", "and", "localization", "in", "C2987364#ent", "<e2>", "littermates", "."], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [19, 20]}}
{"token": ["C0298346#ent", "<e1>", "did", "not", "block", "activation", "of", "C1708804#ent", "<e2>", "and", "MEF2C", ",", "but", "inhibited", "CREB", "phosphorylation", "by", "90", "%", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1708804", "name": "C1708804#ent", "pos": [7, 8]}}
{"token": ["Hypophosphatasia", "is", "a", "rare", "inborn", "error", "metabolism", "characterised", "by", "defective", "bone", "mineralisation", "by", "a", "deficiency", "of", "liver-", ",", "bone-", "or", "C2932888#ent", "<e1>", "to", "mutations", "in", "the", "tissue-nonspecific", "alkaline", "phosphatase", "C1412364#ent", "<e2>", ")", "gene", "."], "h": {"id": "C2932888", "name": "C2932888#ent", "pos": [20, 21]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412364", "name": "C1412364#ent", "pos": [29, 30]}}
{"token": ["These", "recent", "findings", "bode", "well", "for", "clinical", "intervention", "NMDAR", "antagonists", "in", "more", "C0027765#ent", "<e1>", "previously", "thought", ",", "including", "multiple", "sclerosis", "C0007789#ent", "<e2>", "periventricular", "leukomalacia", ",", "and", "spinal", "cord", "injury"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [20, 21]}}
{"token": ["The", "two", "dominant", "negative", "C1419208#ent", "<e1>", "mutants", ",", "therefore", ",", "interfere", "with", "endogenous", "C1419208#ent", "<e1>", "function", "by", "blocking", "the", "C1366909#ent", "<e1>", "not", "zymogen", "granule", "targeting", "of", "endogenous", "C1419208#ent", "<e1>", "."], "h": {"id": "C1419208", "name": "C1419208#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366909", "name": "C1366909#ent", "pos": [19, 20]}}
{"token": ["We", "investigated", "the", "effect", "of", "C3854173#ent", "<e1>", "the", "neurotoxicity", "of", "C0014310#ent", "<e2>", "(", "ENX", ")", "in", "rats", "."], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014310", "name": "C0014310#ent", "pos": [10, 11]}}
{"token": ["C1439284#ent", "<e1>", "AT(1)R", ")", "blockade", "attenuates", "left", "ventricular", "relaxation", "abnormality", "myocardial", "stiffening", "a", "model", "of", "C1135196#ent", "<e2>", "but", "the", "mechanisms", "remain", "unclear", "."], "h": {"id": "C1439284", "name": "C1439284#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1135196", "name": "C1135196#ent", "pos": [15, 16]}}
{"token": ["FdUMP[10", "]", "is", "a", "C1417215#ent", "<e1>", "of", "FdUMP", ",", "a", "suicide", "inhibitor", "of", "C0040085#ent", "<e2>", "TS", ")", ",", "and", "was", "designed", "to", "bypass", "resistance", "5-fluorouracil", "(", "5FU", ")", "."], "h": {"id": "C1417215", "name": "C1417215#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040085", "name": "C0040085#ent", "pos": [13, 14]}}
{"token": ["Lymphocytes", "boosted", "to", "high", "levels", "of", "NK", "activity", "by", "preincubation", "with", "alpha-interferon", "or", "C1522405#ent", "<e1>", "were", "still", "susceptible", "to", "suppression", "by", "C1704465#ent", "<e2>", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704465", "name": "C1704465#ent", "pos": [21, 22]}}
{"token": ["Treatment", "of", "the", "Smac/DIABLO", "transient", "transfectant", "with", "Apo2L/TRAIL", "enhanced", "the", "release", "of", "Smac/DIABLO", "from", "mitochondria", "and", "led", "to", "reduction", "of", "C1334073#ent", "<e1>", "XIAP", ",", "c-IAP1", ",", "and", "C1332415#ent", "<e2>", ")", "."], "h": {"id": "C1334073", "name": "C1334073#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1332415", "name": "C1332415#ent", "pos": [27, 28]}}
{"token": ["To", "compare", "neointimal", "proliferation", "of", "drug-eluting", "stent", "C0394006#ent", "<e1>", ")", "with", "bare", "mental", "stent", "BMS", ")", "by", "optical", "coherence", "tomography", "C0029279#ent", "<e2>", ")", "."], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029279", "name": "C0029279#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "C1413800#ent", "<e1>", "extract", "retards", "absorption", "of", "carbohydrate", "and", "reduces", "post-prandial", "C0020456#ent", "<e2>", "."], "h": {"id": "C1413800", "name": "C1413800#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [14, 15]}}
{"token": ["Topical", "application", "of", "C0032333#ent", "<e1>", "long", "considered", "the", "therapy", "of", "first", "choice", "against", "C0009663#ent", "<e2>", "can", "no", "longer", "be", "recommended", "due", "to", "its", "low", "efficacy", "and", "gross", "toxicity", "."], "h": {"id": "C0032333", "name": "C0032333#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0009663", "name": "C0009663#ent", "pos": [13, 14]}}
{"token": ["The", "correlation", "between", "the", "established", "chemistry", "of", "chemical", "modification", "DNA", "with", "diverse", "C0085169#ent", "<e1>", "and", "activation", "of", "C0694890#ent", "<e2>", "is", "discussed", "."], "h": {"id": "C0085169", "name": "C0085169#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [17, 18]}}
{"token": ["Executive", "dysfunction", "C1334131#ent", "<e1>", ")", "is", "common", "in", "C2931257#ent", "<e2>", "AD", ")", ";", "however", ",", "its", "relationship", "to", "other", "symptoms", "is", "difficult", "to", "assess", "in", "patients", "with", "AD", "."], "h": {"id": "C1334131", "name": "C1334131#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2931257", "name": "C2931257#ent", "pos": [8, 9]}}
{"token": ["Although", "these", "results", "indicate", "that", "C0016377#ent", "<e1>", "has", "an", "\"", "C1537501#ent", "<e2>", "\"", "effect", ",", "the", "analgesia", "both", "preceded", "and", "persisted", "beyond", "the", "inhibition", "of", "iBK", "levels", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [10, 11]}}
{"token": ["These", "C3540017#ent", "<e1>", "are", "also", "known", "under", "the", "C0031640#ent", "<e2>", "CMP-sialic", "acid", "hydrolase", "[", "11", "]", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [8, 9]}}
{"token": ["In", "our", "study", ",", "neurogenesis", "was", "upregulated", "in", "the", "dentate", "gyrus", "DG", ")", "following", "C0917798#ent", "<e1>", "kainic", "acid-induced", "seizure", "in", "C1883559#ent", "<e2>", "animals", ",", "but", "it", "was", "reduced", "in", "FGF-2-/-", "mice", "."], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [20, 21]}}
{"token": ["C0162316#ent", "<e1>", "to", "limit", "the", "hyperferritinaemic", "response", "in", "C0038013#ent", "<e2>", "while", "erythropoietic", "inhibition", "chemotherapy", "dampened", "the", "hypoferraemic", "response", "in", "neutropenic", "sepsis"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [8, 9]}}
{"token": ["An", "investigation", "has", "been", "performed", "with", "a", "new", "parenteral", "iron", "preparation", "iron-poly-(sorbitol-gluconic", "acid", ")", "complex", "(", "Ferastral", ")", "in", "the", "treatment", "with", "C0162316#ent", "<e1>", "anaemia", "associated", "with", "inflammatory", "diseases", "mainly", "C0038013#ent", "<e2>"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [30, 31]}}
{"token": ["C0031090#ent", "<e1>", "restored", "endodontically", "treated", "teeth", "with", "C1420805#ent", "<e2>", "were", "the", "primary", "reasons", "for", "tooth", "extraction"], "h": {"id": "C0031090", "name": "C0031090#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420805", "name": "C1420805#ent", "pos": [7, 8]}}
{"token": ["Based", "on", "its", "role", "in", "inflammation", "and", "matrix", "degradation", "we", "hypothesized", "a", "role", "for", "osteoprotegerin", "(", "OPG", ")", ",", "C2827557#ent", "<e1>", ",", "and", "C2827557#ent", "<e1>", "ligand", "(", "RANKL", ")", "in", "C1956346#ent", "<e1>"], "h": {"id": "C2827557", "name": "C2827557#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [30, 31]}}
{"token": ["The", "rheologic", "disorders", "associated", "with", "C0034063#ent", "<e1>", "reversed", "cardiogenic", "shock", "decompensated", "(", "C0039082#ent", "<e2>", "high", "blood", "viscosity", "Stage", "I", "syndrome", "low", "blood", "viscosity", ",", "but", "reversible", "following", "intensive", "rheologic", "therapy", "."], "h": {"id": "C0034063", "name": "C0034063#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}}
{"token": ["LDL", "isolated", "with", "KBr", "solutions", "appeared", "to", "bind", "20", "-", "45", "%", "more", "of", "the", "C0033215#ent", "<e1>", "present", "in", "serum", "than", "LDL", "isolated", "in", "C3542945#ent", "<e2>", "with", "D2O", "."], "h": {"id": "C0033215", "name": "C0033215#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3542945", "name": "C3542945#ent", "pos": [24, 25]}}
{"token": ["Treatment", "with", "either", "PP2", "or", "C0257685#ent", "<e1>", "induced", "greater", "growth-reduction", "in", "MYL-R", "than", "C1705330#ent", "<e2>", "."], "h": {"id": "C0257685", "name": "C0257685#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705330", "name": "C1705330#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "a", "C0212694#ent", "<e1>", "movement", "or", "structural", "change", "the", "C-terminal", "domains", "C1823878#ent", "<e2>", "and", "Ku80", "that", "may", "contribute", "to", "DNA-PKcs", "binding", "activation", "."], "h": {"id": "C0212694", "name": "C0212694#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1823878", "name": "C1823878#ent", "pos": [13, 14]}}
{"token": ["C0212694#ent", "<e1>", "DNA-PK", ")", ",", "composed", "of", "C1823878#ent", "<e2>", ",", "Ku80", ",", "and", "the", "catalytic", "subunit", "DNA-PKcs", ")", ",", "is", "involved", "in", "repairing", "double-strand", "breaks", "DSBs", ")", "by", "nonhomologous", "end-joining", "NHEJ", ")", "."], "h": {"id": "C0212694", "name": "C0212694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823878", "name": "C1823878#ent", "pos": [7, 8]}}
{"token": ["Except", "for", "cases", "of", "C0011633#ent", "<e1>", "and", "dermatomyositis", ",", "these", "6", "other", "C0206157#ent", "<e2>", "could", "be", "readily", "distinguished", "from", "the", "mitochondrial", "myopathies", "the", "basis", "of", "the", "clinical", "examination", "blood", "tests"], "h": {"id": "C0011633", "name": "C0011633#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0206157", "name": "C0206157#ent", "pos": [12, 13]}}
{"token": ["From", "this", "series", ",", "20a", "was", "found", "to", "be", "the", "most", "potent", "C3536755#ent", "<e1>", "being", "40-fold", "more", "potent", "than", "C0700478#ent", "<e2>", "(", "1", ")", "."], "h": {"id": "C3536755", "name": "C3536755#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0700478", "name": "C0700478#ent", "pos": [19, 20]}}
{"token": ["C0030372#ent", "<e1>", "treatment", "of", "cells", "with", "leptin", "decreased", "the", "C3539616#ent", "<e2>", "response", "to", "GHRH", "stimulation", ",", "but", "the", "C3539616#ent", "<e2>", "response", "to", "GHRP-2", "stimulation", "was", "increased", "."], "h": {"id": "C0030372", "name": "C0030372#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [9, 10]}}
{"token": ["Of", "6", "samples", "that", "were", "negative", "by", "IHC", ",", "the", "C1417407#ent", "<e1>", "deleted", "in", "3", "and", "the", "C3538784#ent", "<e2>", "promoter", "was", "methylated", "in", "2", "."], "h": {"id": "C1417407", "name": "C1417407#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3538784", "name": "C3538784#ent", "pos": [17, 18]}}
{"token": ["The", "C1333949#ent", "<e1>", "and", "exonuclease", "activities", "the", "C0388246#ent", "<e2>", "WRN", ")", "suggest", "that", "it", "functions", "in", "DNA", "transactions", ",", "but", "the", "physiological", "function", "WRN", "remains", "elusive", "."], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0388246", "name": "C0388246#ent", "pos": [7, 8]}}
{"token": ["Spinocerebellar", "ataxia", "type", "5", "C0752123#ent", "<e1>", ")", ",", "one", "of", "the", "genetically", "heterogeneous", "autosomal", "dominant", "C0007758#ent", "<e2>", "was", "assigned", "to", "chromosome", "11", "a", "single", "family", "descending", "from", "the", "grandparents", "of", "President", "Abraham", "Lincoln", "."], "h": {"id": "C0752123", "name": "C0752123#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "the", "relationship", "between", "the", "strong", "ion", "difference", "C0038644#ent", "<e1>", ")", "of", "a", "diluting", "C0056562#ent", "<e2>", "and", "its", "metabolic", "acid-base", "effects", "on", "in", "vitro", "blood", "dilution"], "h": {"id": "C0038644", "name": "C0038644#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0056562", "name": "C0056562#ent", "pos": [15, 16]}}
{"token": ["Pure", "preparations", "of", "C0042071#ent", "<e1>", "processed", "HCC-1", "with", "high", "efficiency", ",", "without", "further", "degrading", "C1705070#ent", "<e2>", "-", "74", "]", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705070", "name": "C1705070#ent", "pos": [14, 15]}}
{"token": ["Early", "examples", "of", "such", "agents", "are", "the", "so-called", "CNS", "C0002763#ent", "<e1>", ",", "e.g.", ",", "the", "amphetamines", ",", "C0031447#ent", "<e2>", ",", "ephedrine", ",", "etc", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031447", "name": "C0031447#ent", "pos": [17, 18]}}
{"token": ["C3537369#ent", "<e1>", "and", "Spred2", "suppressed", "constitutively", "activated", "C0812234#ent", "<e2>", "(V14RhoA)-induced", "stress", "fiber", "formation", "and", "serum", "response", "factor", "activation"], "h": {"id": "C3537369", "name": "C3537369#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [7, 8]}}
{"token": ["C3536742#ent", "<e1>", "infusion", "caused", "C1414509#ent", "<e2>", "elevations", "of", "systolic", "blood", "pressure"], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414509", "name": "C1414509#ent", "pos": [4, 5]}}
{"token": ["Staging", "by", "endoscopies", ",", "ultrasonography", "revealed", "colon", "C0547058#ent", "<e1>", "and", "periportal", "fibrosis", "by", "C0020541#ent", "<e2>", "esophageal", "varices"], "h": {"id": "C0547058", "name": "C0547058#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020541", "name": "C0020541#ent", "pos": [13, 14]}}
{"token": ["They", "are", "glycine", ",", "methoxytryptophan", ",", "tryptophan", ",", "cysteine", ",", "alanine", ",", "sarcosine", ",", "dehydroalanine", ",", "and", "alpha-aminobutyric", "acid", "C0389119#ent", "<e1>", "alanine", "for", "C0389122#ent", "<e2>", "."], "h": {"id": "C0389119", "name": "C0389119#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0389122", "name": "C0389122#ent", "pos": [23, 24]}}
{"token": ["Planimetric", "measurements", "the", "alveolar", "epithelium", "that", "the", "squamous", "transformation", "and", "its", "partial", "reversal", "by", "C0003873#ent", "<e1>", "coincide", "with", "the", "rise", "and", "decline", "of", "C0014599#ent", "<e2>"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014599", "name": "C0014599#ent", "pos": [23, 24]}}
{"token": ["To", "look", "for", "evidence", "that", "angiogenin", "is", "involved", "in", "C1290884#ent", "<e1>", "we", "examined", "plasma", "and", "synovial", "fluid", "C0876942#ent", "<e2>", ")", "samples", "from", "rheumatology", "patients", "and", "synovial", "fibroblast", "cell", "culture", "supernatants", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0876942", "name": "C0876942#ent", "pos": [17, 18]}}
{"token": ["Amino", "acid", "sequence", "signatures", "derived", "that", "are", "unique", "for", "C1706586#ent", "<e1>", "different", "subsets", "of", "(", "putative", ")", "C0033649#ent", "<e2>"], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033649", "name": "C0033649#ent", "pos": [17, 18]}}
{"token": ["This", "study", "aims", "to", "dissociate", "the", "respective", "roles", "of", "systemic", "nephrosis", "of", "the", "intrarenal", "effects", "of", "proteinuria", "in", "the", "pathogenesis", "of", "focal", "segmental", "glomerulosclerosis", "C0220769#ent", "<e1>", ")", "in", "adriamycin", "C0027720#ent", "<e2>", "."], "h": {"id": "C0220769", "name": "C0220769#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0027720", "name": "C0027720#ent", "pos": [29, 30]}}
{"token": ["These", "results", "suggest", "that", "C1704827#ent", "<e1>", "may", "play", "a", "role", "in", "the", "transport", "of", "C0055461#ent", "<e2>", "and", "quinidine", "related", "compounds", "in", "the", "kidney", "."], "h": {"id": "C1704827", "name": "C1704827#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [14, 15]}}
{"token": ["In", "this", "report", ",", "we", "have", "investigated", "the", "transport", "properties", "of", "C1704827#ent", "<e1>", "and", "show", "that", "this", "protein", "can", "confer", "resistance", "to", "C0055461#ent", "<e2>", "and", "quinidine", "when", "overexpressed", "in", "bacteria", "."], "h": {"id": "C1704827", "name": "C1704827#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [22, 23]}}
{"token": ["beta-Catenin", "mediates", "the", "transcription", "of", "the", "ZBP1", "gene", "while", "C1825576#ent", "<e1>", "promotes", "the", "stability", "of", "C1332803#ent", "<e2>", "mRNA", "."], "h": {"id": "C1825576", "name": "C1825576#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [15, 16]}}
{"token": ["We", "further", "demonstrate", "feedback", "regulation", "finding", "that", "C1825576#ent", "<e1>", "physically", "associates", "with", "C1332803#ent", "<e2>", "mRNA", "in", "vivo", "increases", "its", "stability", "."], "h": {"id": "C1825576", "name": "C1825576#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "the", "in", "vivo", "C3537142#ent", "<e1>", "and", "anti-ischemic", "effects", "of", "C0077141#ent", "<e2>", "in", "coronary", "ligated", "rats", "were", "investigated", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0077141", "name": "C0077141#ent", "pos": [13, 14]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "investigate", "the", "effect", "of", "the", "nNOS", "inhibitor", "C0214185#ent", "<e1>", "(", "7-NI", ")", ",", "on", "ethanol-induced", "locomotor", "sensitization", "and", "C1413682#ent", "<e2>", "in", "DBA/2J", "mice"], "h": {"id": "C0214185", "name": "C0214185#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413682", "name": "C1413682#ent", "pos": [24, 25]}}
{"token": ["In", "the", "present", "study", "the", "effect", "of", "C0674428#ent", "<e1>", "on", "the", "pharmacokinetics", "and", "tolerability", "of", "once-daily", "C0939237#ent", "<e2>", "was", "evaluated", "in", "healthy", "subjects"], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0939237", "name": "C0939237#ent", "pos": [16, 17]}}
{"token": ["No", "cross-reactivity", "was", "observed", "with", "bovine", "serum", "albumin", "BSA", ")", ",", "C3537198#ent", "<e1>", "HSA", ")", ",", "gliadin", "and", "C1418244#ent", "<e2>", "."], "h": {"id": "C3537198", "name": "C3537198#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418244", "name": "C1418244#ent", "pos": [18, 19]}}
{"token": ["C0163410#ent", "<e1>", "GlcT", ")", "and", "lactosylceramide", "synthase", "C0268151#ent", "<e2>", ")", "are", "key", "enzymes", "for", "the", "synthesis", "of", "major", "glycosphingolipids", "of", "vertebrates", "."], "h": {"id": "C0163410", "name": "C0163410#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268151", "name": "C0268151#ent", "pos": [7, 8]}}
{"token": ["The", "action", "is", "not", "duplicated", "by", "N-alkylimidazoles", "which", "have", "greater", "potency", "as", "inhibitors", "of", "thromboxane", "synthetase", "the", "effect", "of", "C0020924#ent", "<e1>", "was", "antagonized", "by", "C0022245#ent", "<e2>", "or", "theophylline", "."], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [24, 25]}}
{"token": ["Our", "study", "reveals", "that", "C1313497#ent", "<e1>", "hydrolyzes", "dystrophin", ",", "myosin", ",", "and", "C1417656#ent", "<e2>", ",", "but", "not", "laminin", ",", "alpha-actinin", ",", "vinculin", ",", "and", "connectin", "in", "vitro"], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417656", "name": "C1417656#ent", "pos": [12, 13]}}
{"token": ["Except", "for", "its", "relative", "C2720163#ent", "<e1>", "insusceptibility", "of", "oestrogen", "synthesizing", "C3541394#ent", "<e2>", "to", "steroid", "inhibitors", "choriocarcinoma", "appears", "to", "be", "a", "useful", "model", "of", "placental", "oestrogen", "."], "h": {"id": "C2720163", "name": "C2720163#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}}
{"token": ["Steroids", ",", "at", "concentrations", "previously", "shown", "to", "inhibit", "C2720163#ent", "<e1>", "3beta-hydroxysteroid", "dehydrogenase", ",", "did", "not", "inhibit", "choriocarcinoma", "C3541394#ent", "<e2>", "."], "h": {"id": "C2720163", "name": "C2720163#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["Renal", "artery", "stenosis", "C0034678#ent", "<e1>", ")", "is", "a", "progressive", "manifestation", "of", "C0003850#ent", "<e2>", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [11, 12]}}
{"token": ["RT-PCR", "analysis", "ARPE-19", "cells", "found", "mRNA", "message", "for", "multiple", "extracellular", "degradative", "enzymes", "ectonucleotide", "pyrophosphatase/phosphodiesterase", "eNPP1", "C3540601#ent", "<e1>", ",", "and", "eNPP3", ";", "the", "C1414412#ent", "<e2>", "NTPDase2", ",", "NTPDase3", ",", "and", "some", "message", "for", "NTPDase1", "."], "h": {"id": "C3540601", "name": "C3540601#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1414412", "name": "C1414412#ent", "pos": [22, 23]}}
{"token": ["These", "observations", "let", "us", "to", "speculate", "that", "C1142985#ent", "<e1>", "will", "become", "a", "new", "therapeutic", "approach", "the", "treatment", "of", "C0400966#ent", "<e2>", "the", "hepatic", "manifestation", "insulin", "resistant", "patients", "with", "the", "metabolic", "syndrome"], "h": {"id": "C1142985", "name": "C1142985#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0400966", "name": "C0400966#ent", "pos": [18, 19]}}
{"token": ["Many", "other", "factors", "--", "linked", "to", "the", "time", "of", "C3541334#ent", "<e1>", "--", "may", "be", "involved", "in", "vascular", "diseases", "such", "as", "C1704321#ent", "<e2>", "dyslipidemia", ",", "hypertension", "and", "drugs", "."], "h": {"id": "C3541334", "name": "C3541334#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "establish", "a", "novel", "mechanism", "of", "C0393003#ent", "<e1>", "function", "at", "target", "promoters", ":", "cooperation", "with", "C3538848#ent", "<e2>", "."], "h": {"id": "C0393003", "name": "C0393003#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3538848", "name": "C3538848#ent", "pos": [16, 17]}}
{"token": ["C1413947#ent", "<e1>", "downregulation", "is", "specific", "to", "oncogenic", "C0034678#ent", "<e2>", "since", "another", "oncogenic", "family", "member", "does", "not", "downregulate", "C1413947#ent", "<e1>", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413947", "name": "C1413947#ent", "pos": [0, 1]}}
{"token": ["It", "is", "known", "that", "C0018994#ent", "<e1>", "is", "a", "rare", "complication", "of", "cholecystitis", "and", "C0267853#ent", "<e2>", "."], "h": {"id": "C0018994", "name": "C0018994#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0267853", "name": "C0267853#ent", "pos": [13, 14]}}
{"token": ["Hill", "plots", "of", "competition", "studies", "were", "consistent", "with", "Mg2+", "positive", "co-operativity", "in", "C1419692#ent", "<e1>", ",", "but", "not", "in", "C0268164#ent", "<e2>", "or", "LP2", "."], "h": {"id": "C1419692", "name": "C1419692#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [18, 19]}}
{"token": ["The", "variance", "in", "LDH", "C1412365#ent", "<e1>", "pattern", "bore", "no", "relationship", "to", "the", "state", "of", "C0011847#ent", "<e2>", "but", "appeared", "to", "arise", "from", "other", "genetic", "determinants"], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [14, 15]}}
{"token": ["C0268009#ent", "<e1>", "also", "decreased", "C3536742#ent", "<e2>", "release", "induced", "by", "56", "mM", "K+", "and", "by", "removal", "of", "NaCl", "from", "the", "perfusion", "medium"], "h": {"id": "C0268009", "name": "C0268009#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [4, 5]}}
{"token": ["C1517662#ent", "<e1>", "is", "a", "C3537240#ent", "<e2>", "that", "acts", "on", "both", "resistance", "and", "capacitance", "vessels"], "h": {"id": "C1517662", "name": "C1517662#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [4, 5]}}
{"token": ["C1517662#ent", "<e1>", "does", "not", "inhibit", "C3537240#ent", "<e2>", "effects", "of", "5-HT", "."], "h": {"id": "C1517662", "name": "C1517662#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [5, 6]}}
{"token": ["We", "conclude", "that", "C1517662#ent", "<e1>", "is", "not", "a", "C3537240#ent", "<e2>", "but", "seems", "to", "inhibit", "vasoconstriction", "."], "h": {"id": "C1517662", "name": "C1517662#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [8, 9]}}
{"token": ["C1517662#ent", "<e1>", "showed", "no", "direct", "C3537240#ent", "<e2>", "effects", "but", "could", "completely", "antagonise", "the", "5-HT-induced", "vasoconstrictor", "responses", ",", "suggesting", "that", "this", "response", "was", "5-HT2", "receptor-mediated", "."], "h": {"id": "C1517662", "name": "C1517662#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3537240", "name": "C3537240#ent", "pos": [5, 6]}}
{"token": ["Pain", "is", "the", "hallmark", "of", "patients", "with", "C0085696#ent", "<e1>", "CP", ")", "and", "chronic", "pelvic", "pain", "syndrome", "(", "C1840061#ent", "<e2>", ")", "."], "h": {"id": "C0085696", "name": "C0085696#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1840061", "name": "C1840061#ent", "pos": [17, 18]}}
{"token": ["However", ",", "the", "most", "common", "type", "is", "the", "C0085696#ent", "<e1>", "called", "\"", "chronic", "pelvic", "pain", "syndrome", "\"", "(", "C1840061#ent", "<e2>", ")", "which", "is", "subdivided", "into", "an", "inflammatory", "and", "a", "noninflammatory", "form"], "h": {"id": "C0085696", "name": "C0085696#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1840061", "name": "C1840061#ent", "pos": [18, 19]}}
{"token": ["C0085696#ent", "<e1>", "or", "Chronic", "Pelvic", "Pain", "Syndrome", "[", "C1840061#ent", "<e2>", "]", ",", "is", "a", "common", "disorder", "characterized", "by", "pelvic", "pain", "varying", "degrees", "of", "inflammation", "in", "expressed", "prostatic", "secretions", "EPS", ")", "."], "h": {"id": "C0085696", "name": "C0085696#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1840061", "name": "C1840061#ent", "pos": [8, 9]}}
{"token": ["On", "the", "5th", "day", "of", "C1848296#ent", "<e1>", "administration", ",", "osmotic", "pumps", "recombinant", "human", "C1420314#ent", "<e2>", "(", "200", "microg/day", ")", "were", "implanted", "into", "the", "peritoneum", "of", "the", "rats", "."], "h": {"id": "C1848296", "name": "C1848296#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "Smad2", "and", "Smad3", "triggered", "activation", "of", "C0084340#ent", "<e1>", "and", "RhoB", "C0018296#ent", "<e2>", "and", "long-term", "actin", "reorganization", "Swiss", "3T3", "fibroblasts", "."], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0018296", "name": "C0018296#ent", "pos": [13, 14]}}
{"token": ["The", "C1514208#ent", "<e1>", "similar", "to", "C1423874#ent", "<e2>", "mammalian", "cells"], "h": {"id": "C1514208", "name": "C1514208#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1423874", "name": "C1423874#ent", "pos": [5, 6]}}
{"token": ["The", "effect", "of", "the", "glycosylases", "UDG", "and", "C1709289#ent", "<e1>", "and", "the", "C0012892#ent", "<e2>", "also", "characterized", "."], "h": {"id": "C1709289", "name": "C1709289#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [11, 12]}}
{"token": ["In", "vivo", "administration", "of", "C0028005#ent", "<e1>", ",", "nifedipine", "and", "diltiazem", ",", "known", "as", "C1562036#ent", "<e2>", "suppressed", "the", "clofibrate-evoked", "induction", "of", "activities", "of", "peroxisomal", "enzymes", "such", "as", "the", "peroxisomal", "fatty", "acyl-CoA", "oxidizing", "system", "and", "carnitine", "acetyltransferase"], "h": {"id": "C0028005", "name": "C0028005#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1562036", "name": "C1562036#ent", "pos": [13, 14]}}
{"token": ["OSU-03012", "promoted", "the", "release", "of", "C1332804#ent", "<e1>", "the", "lysosomal", "compartment", "release", "of", "C1826618#ent", "<e2>", "from", "mitochondria", "."], "h": {"id": "C1332804", "name": "C1332804#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1826618", "name": "C1826618#ent", "pos": [12, 13]}}
{"token": ["C0058361#ent", "<e1>", "synthesized", "in", "Morris", "hepatoma", "7777", "cells", "as", "a", "C0072522#ent", "<e2>", "with", "mannose-6-phosphate", "residues", "mediated", "mannose-6-phosphate-specific", "receptor-dependent", "uptake", "in", "human", "skin", "fibroblasts", "."], "h": {"id": "C0058361", "name": "C0058361#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", "to", "C0162758#ent", "<e1>", "ECT", ",", "bupropion", "and", "C3540022#ent", "<e2>", "increase", "extracellular", "dopamine", "concentrations", "not", "only", "in", "the", "frontal", "cortex", "also", "in", "the", "nucleus", "accumbens", "striatum", "."], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540022", "name": "C3540022#ent", "pos": [9, 10]}}
{"token": ["Rheumatoid", "arthritis", "RA", ")", "and", "C3714757#ent", "<e1>", "JRA", ")", "are", "systemic", "autoimmune", "diseases", "characterized", "by", "C1739148#ent", "<e2>", "and", "a", "wide", "range", "of", "extraarticular", "manifestations", "."], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1739148", "name": "C1739148#ent", "pos": [15, 16]}}
{"token": ["Hence", "the", "study", "conclude", "that", "the", "elevated", "melatonin", "levels", "among", "C3714757#ent", "<e1>", "patients", "with", "C1739148#ent", "<e2>", "its", "close", "relation", "to", "disease", "activity", "than", "disease", "severity", "that", "melatonin", "might", "play", "a", "promoting", "role", "in", "rheumatoid", "arthritis"], "h": {"id": "C3714757", "name": "C3714757#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1739148", "name": "C1739148#ent", "pos": [14, 15]}}
{"token": ["Involvement", "of", "the", "ascending", "aorta", "other", "C0442893#ent", "<e1>", "well", "known", "and", "can", "imitate", "C0003511#ent", "<e2>"], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003511", "name": "C0003511#ent", "pos": [13, 14]}}
{"token": ["C0017205#ent", "<e1>", "the", "most", "prevalent", "C0037899#ent", "<e2>", ",", "is", "caused", "by", "the", "deficient", "activity", "of", "acid", "beta-glucosidase", "mainly", "due", "to", "mutations", "in", "the", "GBA", "gene"], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037899", "name": "C0037899#ent", "pos": [5, 6]}}
{"token": ["C0017205#ent", "<e1>", "the", "most", "prevalent", "C0037899#ent", "<e2>", "is", "characterized", "by", "an", "accumulation", "of", "sphingolipids", "mainly", "in", "cells", "of", "the", "reticuloendothelial", "cells", "and", "is", "due", "to", "decreased", "activity", "of", "the", "lysosomal", "enzyme", "glucocerebrosidase", "GCase", ")", "."], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037899", "name": "C0037899#ent", "pos": [5, 6]}}
{"token": ["When", "C1417081#ent", "<e1>", "were", "incubated", "with", "verapamil", ",", "C0010592#ent", "<e2>", "orthovanadate", ",", "and", "quinidine", ",", "which", "are", "known", "to", "reverse", "P-glycoprotein", "multidrug", "resistance", "MDR", ")", ",", "Dox", "accumulated", "also", "in", "deeper", "cell", "layers"], "h": {"id": "C1417081", "name": "C1417081#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [8, 9]}}
{"token": ["We", "analyzed", "the", "occurrence", "and", "clinical", "features", "of", "myoclonus", "in", "patients", "with", "C2316810#ent", "<e1>", "ESRD", ")", "who", "were", "treated", "with", "gabapentin", "(", "C1413968#ent", "<e2>", ")", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413968", "name": "C1413968#ent", "pos": [22, 23]}}
{"token": ["From", "the", "dissociation", "constants", ",", "it", "was", "found", "that", "C1417092#ent", "<e1>", "DH", "had", "a", "much", "stronger", "affinity", "to", "C2350558#ent", "<e2>", "8-sub-2'-AMP", "than", "did", "NAD-dependent", "DH", "and", "phosphorylase", "."], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [18, 19]}}
{"token": ["Previous", "reports", "that", "diabetogenic", "lymphocytes", "did", "not", "induce", "C0011849#ent", "<e1>", "in", "nonobese", "diabetic", "mice", "suggested", "the", "critical", "role", "of", "Fas-Fas", "ligand", "C1539478#ent", "<e2>", ")", "interaction", "in", "pancreatic", "beta", "cell", "apoptosis"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [21, 22]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "outline", "the", "worldwide", "significance", "of", "C0010414#ent", "<e1>", "and", "review", "developments", "the", "management", "of", "C0085436#ent", "<e2>"], "h": {"id": "C0010414", "name": "C0010414#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085436", "name": "C0085436#ent", "pos": [20, 21]}}
{"token": ["In", "the", "ventral", "thalamus", "the", "primary", "visual", "cortices", "areas", "17", "and", "18", ")", "project", "in", "a", "topographic", "manner", "to", "both", "the", "perigeniculate", "nucleus", "C1420354#ent", "<e1>", ")", "and", "the", "C1412566#ent", "<e2>", "."], "h": {"id": "C1420354", "name": "C1420354#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1412566", "name": "C1412566#ent", "pos": [28, 29]}}
{"token": ["To", "study", "the", "effect", "of", "dl-3-n-butylphthalide", "(", "C1428910#ent", "<e1>", ")", "on", "regional", "cerebral", "blood", "flow", "rCBF", ")", "in", "C0007785#ent", "<e2>", "rats", "."], "h": {"id": "C1428910", "name": "C1428910#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [18, 19]}}
{"token": ["The", "association", "of", "GST-C3", "G", "with", "C0812252#ent", "<e1>", "was", "also", "dose", "dependent", "and", "demonstrated", "that", "insulin", "reduced", "the", "affinity", "of", "C0812252#ent", "<e1>", "for", "C1415285#ent", "<e1>", "any", "effect", "on", "C0812252#ent", "<e1>", "protein", "levels"], "h": {"id": "C1415285", "name": "C1415285#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [6, 7]}}
{"token": ["Histologic", "examination", "mild", "focal", "cholecystitis", "the", "gallbladder", "of", "four", "of", "six", "animals", ",", "C0521610#ent", "<e1>", "three", "of", "six", "animals", ",", "and", "foci", "of", "C1167767#ent", "<e2>", "two", "animals", "."], "h": {"id": "C0521610", "name": "C0521610#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1167767", "name": "C1167767#ent", "pos": [23, 24]}}
{"token": ["Although", ",", "total", "and", "phosphorylated", "glycogen", "synthase", "levels", "were", "similar", "in", "normal", "and", "C0011884#ent", "<e1>", "activation", "of", "glycogen", "synthase", "C0017755#ent", "<e2>", "was", "remarkable", "increased", "."], "h": {"id": "C0011884", "name": "C0011884#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017755", "name": "C0017755#ent", "pos": [19, 20]}}
{"token": ["We", "have", "analyzed", "16", "missense", "mutations", "the", "C2932888#ent", "<e1>", "TNAP", ")", "gene", "found", "in", "patients", "with", "C0268412#ent", "<e2>", "."], "h": {"id": "C2932888", "name": "C2932888#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268412", "name": "C0268412#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "the", "beta1", "subunit", "C2350345#ent", "<e1>", "is", "not", "a", "p53", "downstream", "target", "C0017337#ent", "<e2>", ",", "but", "can", "be", "induced", "by", "cold", "shock", "the", "chemotherapeutic", "drug", "etoposide", "in", "a", "p53-independent", "manner", "."], "h": {"id": "C2350345", "name": "C2350345#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "the", "effect", "of", "a", "short-term", "overexpression", "of", "C2350345#ent", "<e1>", "specifically", "in", "the", "liver", "by", "adenovirus-mediated", "transfer", "of", "a", "C0017337#ent", "<e2>", "encoding", "a", "constitutively", "active", "form", "AMPKalpha2", "(", "AMPKalpha2-CA", ")", "."], "h": {"id": "C2350345", "name": "C2350345#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["In", "mouse", "osteoblastic", "cells", "cytosolic", "PLA2", "C1333201#ent", "<e1>", ")", "mRNA", "and", "its", "protein", "were", "C0907533#ent", "<e2>", "expressed", "and", "increased", "approximately", "2-fold", "by", "IL-1alpha", ",", "but", "secretory", "PLA2", "mRNA", "was", "not", "detected", "."], "h": {"id": "C1333201", "name": "C1333201#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}}
{"token": ["Both", "the", "MFH", "and", "the", "IMT", ",", "but", "not", "the", "C1426839#ent", "<e1>", ",", "showed", "nuclear", "p53", "expression", "and", "mutations", "of", "the", "C1705526#ent", "<e2>"], "h": {"id": "C1426839", "name": "C1426839#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [21, 22]}}
{"token": ["Male", "(", "NZW", "x", "BXSB)F1", "(", "W/BF1", ")", "mice", "develop", "acute", "systemic", "autoimmune", "disease", "by", "degenerative", "coronary", "vascular", "disease", "C0007820#ent", "<e1>", ")", "with", "myocardial", "infarctions", "hypertension", ",", "C0040034#ent", "<e2>", ",", "glomerulonephritis", ",", "and", "persistently", "elevated", "levels", "of", "circulating", "immune", "complexes"], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [27, 28]}}
{"token": ["Transfection", "of", "Hep3B", "human", "hepatoma", "cells", "inactive", "Cdc25A", "mutant", "enhanced", "C0055816#ent", "<e1>", "action", "on", "C1370600#ent", "<e2>", "phosphorylation", ",", "whereas", "over-expression", "of", "Cdc25A", "attenuated", "this", "C0055816#ent", "<e1>", "."], "h": {"id": "C0055816", "name": "C0055816#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [14, 15]}}
{"token": ["Toxic", "death", "be", "prevented", "by", "vaccinating", "the", "mice", "with", "concentrated", "suspensions", "of", "C1334043#ent", "<e1>", "inactivated", "by", "formalin", "or", "C0031428#ent", "<e2>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "the", "effect", "of", "C0770893#ent", "<e1>", "(", "M", ")", "treatment", "on", "Hcy", "levels", "C0038317#ent", "<e2>", "and", "glycide", "tolerance", "PCOS", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [14, 15]}}
{"token": ["The", "C0023899#ent", "<e1>", "is", "one", "of", "the", "primary", "targets", "of", "C0018133#ent", "<e2>", "GVHD", ")", ",", "which", "is", "the", "principal", "complication", "that", "occurs", "after", "allogeneic", "intestinal", "transplantation"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018133", "name": "C0018133#ent", "pos": [10, 11]}}
{"token": ["Seven", "of", "the", "cDNAs", "were", "C1512488#ent", "<e1>", "to", "known", "mouse", "or", "human", "genes", "carboxylesterase", ",", "coagulation", "factor", "X", "amine", "N-sulphotransferase", "C1538611#ent", "<e2>", "cytochrome", "c", "oxidase", "subunit", "IV", "golgin-245", ",", "thioredoxin", "reductase", "betaine-homocysteine", "methyl", "transferase", "and", "the", "remainder", "were", "novel", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1538611", "name": "C1538611#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "suggest", "that", "C0235480#ent", "<e1>", "plays", "an", "important", "role", "in", "the", "pathogenesis", "of", "C0029882#ent", "<e2>", "effusion", "by", "stimulating", "mucous", "glycoprotein", "in", "vitro"], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [14, 15]}}
{"token": ["Several", "toxic", "agents", "such", "as", "mercurials", "and", "agents", "with", "a", "sulphydryl", "group", "e.g.", ",", "gold", "salts", "D-penicillamine", "and", "C0006938#ent", "<e1>", ")", ",", "are", "associated", "with", "occurrence", "of", "C0017665#ent", "<e2>"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0017665", "name": "C0017665#ent", "pos": [27, 28]}}
{"token": ["Our", "epidemiological", "study", "an", "increased", "risk", "of", "C0030304#ent", "<e1>", "as", "well", "as", "extrapancreatic", "cancer", "patients", "with", "C0149521#ent", "<e2>", "with", "the", "general", "population"], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [16, 17]}}
{"token": ["In", "vivo", "C1425409#ent", "<e1>", "altered", "the", "NZB/NZW", "C0031065#ent", "<e2>", "to", "be", "a", "model", "for", "human", "SLE", "nephritis"], "h": {"id": "C1425409", "name": "C1425409#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031065", "name": "C0031065#ent", "pos": [7, 8]}}
{"token": ["Our", "case", "is", "an", "uncommon", "case", "of", "acute", "onset", "facial", "palsy", "due", "to", "C0041296#ent", "<e1>", ",", "in", "the", "absence", "of", "any", "ear", "findings", "resembling", "C0376175#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0376175", "name": "C0376175#ent", "pos": [24, 25]}}
{"token": ["Interest", "has", "also", "focused", "on", "the", "geographical", "distribution", "the", "C1704797#ent", "<e1>", "particularly", "in", "considering", "epidemiological", "aspects", "C0019693#ent", "<e2>", "its", "impact", "on", "health", "economics"], "h": {"id": "C1704797", "name": "C1704797#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [16, 17]}}
{"token": ["Estrogens", "occurring", "naturally", "in", "the", "body", "are", "metabolized", "to", "catecholestrogens", "(", "2-", "and", "C0097109#ent", "<e1>", ")", "by", "the", "cytochrome", "P450", "C3541394#ent", "<e2>", "."], "h": {"id": "C0097109", "name": "C0097109#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [20, 21]}}
{"token": ["Cytosols", "from", "such", "patients", "are", "valuable", "for", "biochemical", "studies", "of", "the", "C0242417#ent", "<e1>", ",", "but", "are", "not", "generally", "available", "because", "C1863999#ent", "<e2>", "is", "a", "rare", "disorder", "."], "h": {"id": "C0242417", "name": "C0242417#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1863999", "name": "C1863999#ent", "pos": [20, 21]}}
{"token": ["A", "cellular", "disintegrin", "metalloproteinase", "(", "C1314771#ent", "<e1>", ")", "is", "a", "new", "family", "of", "C0017337#ent", "<e2>", "with", "structural", "homology", "to", "the", "snake", "venom", "metalloproteinases", "disintegrins", "."], "h": {"id": "C1314771", "name": "C1314771#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["This", "disorder", "clinically", "resembles", "the", "previously", "reported", "C3899988#ent", "<e1>", "canine", "hereditary", "retinal", "degenerations", "collectively", "termed", "progressive", "retinal", "atrophy", "C3669212#ent", "<e2>", ")", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3669212", "name": "C3669212#ent", "pos": [18, 19]}}
{"token": ["It", "is", "classed", "as", "one", "of", "the", "C3899988#ent", "<e1>", "canine", "generalised", "Progressive", "Retinal", "Atrophies", "(", "C3669212#ent", "<e2>", ")", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3669212", "name": "C3669212#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "effects", "of", "azole", "antimycotics", "clotrimazole", "ketoconazole", ",", "econazole", ",", "oxiconazole", ",", "C0025942#ent", "<e1>", ",", "fluconazole", ",", "and", "itraconazole", "on", "PXR-mediated", "expression", "of", "C1142644#ent", "<e2>", "."], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [18, 19]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [29, 30]}}
{"token": ["The", "occurrence", "of", "fatal", "C0030446#ent", "<e1>", "peritonitis", "in", "a", "patient", "receiving", "C0304370#ent", "<e2>", "and", "an", "antiparkinsonian", "agent", "described", "."], "h": {"id": "C0030446", "name": "C0030446#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0304370", "name": "C0304370#ent", "pos": [11, 12]}}
{"token": ["The", "cellular", "concentration", "this", "C0950398#ent", "<e1>", "is", "governed", "by", "a", "feedback", "mechanism", "in", "which", "C1418833#ent", "<e2>", "regulates", "its", "own", "synthesis", "."], "h": {"id": "C0950398", "name": "C0950398#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418833", "name": "C1418833#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "C1843273#ent", "<e1>", "is", "a", "unique", "C0039082#ent", "<e2>", "with", "characteristic", "clinical", "features", ",", "laboratory", "changes", "and", "renal", "biopsy", "."], "h": {"id": "C1843273", "name": "C1843273#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}}
{"token": ["Hence", ",", "C3889744#ent", "<e1>", "appears", "to", "signal", "through", "a", "larger", "diversity", "of", "C0086376#ent", "<e2>", "US28", ",", "allowing", "it", "to", "couple", "to", "proliferative", "and", "antiapoptotic", "signaling", "pathways"], "h": {"id": "C3889744", "name": "C3889744#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["By", "constructing", "nearly", "isogenic", "lines", "C0027721#ent", "<e1>", ")", "that", "differ", "only", "at", "a", "single", "quantitative", "trait", "locus", "C0597336#ent", "<e2>", ")", ",", "we", "fine-mapped", "the", "yield-improving", "C0597336#ent", "<e2>", "qGY2", "-", "1", "to", "a", "102.9-kb", "region", "on", "rice", "chromosome", "2"], "h": {"id": "C0027721", "name": "C0027721#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597336", "name": "C0597336#ent", "pos": [17, 18]}}
{"token": ["The", "C1417679#ent", "<e1>", "for", "ocular", "albinisim", "type", "1", "OA1", ")", "and", "the", "Xenopus", "laevis-like", "apical", "protein", "C1822720#ent", "<e2>", ")", "map", "between", "amelogenin", "(", "AMELX", ")", "and", "the", "pseudoautosomal", "boundary", "the", "distal", "region", "the", "human", "X", "chromosome", "short", "arm"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1822720", "name": "C1822720#ent", "pos": [16, 17]}}
{"token": ["C0671550#ent", "<e1>", "induction", "and", "invasion", "were", "blocked", "by", "the", "C1519050#ent", "<e2>", "LY294002", "and", "wortmannin", "and", "by", "rapamycin", ",", "but", "not", "by", "the", "MEK", "inhibitor", "PD98059", "."], "h": {"id": "C0671550", "name": "C0671550#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1519050", "name": "C1519050#ent", "pos": [9, 10]}}
{"token": ["Plasma", "exchange", "PE", ")", "is", "the", "most", "important", "treatment", "in", "C2717961#ent", "<e1>", "TMAs", ")", "mainly", "encompassing", "C0034155#ent", "<e2>", "TTP", ")", "and", "adult", "hemolytic", "syndrome", "HUS", ")", "."], "h": {"id": "C2717961", "name": "C2717961#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0034155", "name": "C0034155#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "C0142554#ent", "<e1>", "independent", "of", "cell", "type", "of", "C2987634#ent", "<e2>", ",", "as", "would", "be", "expected", "for", "a", "compound", "that", "modulates", "post-receptor", "events", "."], "h": {"id": "C0142554", "name": "C0142554#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "p38alpha", ",", "a", "member", "of", "the", "C0380241#ent", "<e1>", "will", "phosphorylate", "C1826396#ent", "<e2>", "and", "NFH", "on", "their", "side-arm", "domains", "."], "h": {"id": "C0380241", "name": "C0380241#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1826396", "name": "C1826396#ent", "pos": [15, 16]}}
{"token": ["In", "the", "presence", "of", "added", "iron", "--", "C0013618#ent", "<e1>", ",", "addition", "of", "either", "H2O2", "or", "xanthine", "and", "C1421531#ent", "<e2>", "rise", "to", "hydroxyl", "radical", "formation", "in", "most", "cases", "was", "not", "superoxide-dependent", "."], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421531", "name": "C1421531#ent", "pos": [17, 18]}}
{"token": ["These", "results", "demonstrate", "that", "C1424250#ent", "<e1>", "rapidly", "induces", "Stat3", "serine", "phosphorylation", "through", "a", "C0173879#ent", "<e2>", "dependent", "pathway"], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0173879", "name": "C0173879#ent", "pos": [13, 14]}}
{"token": ["Screening", "of", "a", "panel", "of", "C1333186#ent", "<e1>", "members", "showed", "that", "C0003015#ent", "<e2>", "cystatins", "A", "B", ")", "and", "low", "Mr", "kininogen", "type", "3", ")", "did", "not", "inhibit", "pig", "legumain", "."], "h": {"id": "C1333186", "name": "C1333186#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [10, 11]}}
{"token": ["Fourteen", "patients", "with", "C0003873#ent", "<e1>", "equivalent", "therapeutic", "doses", "the", "antinflammatory", "drugs", "aspirin", "4", "gm/day", ",", "and", "C0887323#ent", "<e2>", "2.4", "gm/day", ",", "in", "randomized", "order", "seven", "days", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0887323", "name": "C0887323#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "targeting", "C1418489#ent", "<e1>", "enzymes", ",", "either", "directly", "or", "through", "inhibition", "of", "C1822686#ent", "<e2>", ",", "appears", "as", "a", "promising", "approach", "for", "the", "treatment", "of", "certain", "tumours", "."], "h": {"id": "C1418489", "name": "C1418489#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1822686", "name": "C1822686#ent", "pos": [13, 14]}}
{"token": ["It", "is", "conceivable", "that", "compression", "of", "the", "basilar", "artery", "have", "caused", "isolated", "C0271355#ent", "<e1>", "disclosed", "by", "MRI", "with", "C1413713#ent", "<e2>", "."], "h": {"id": "C0271355", "name": "C0271355#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413713", "name": "C1413713#ent", "pos": [18, 19]}}
{"token": ["Six", "patients", "had", "C0275524#ent", "<e1>", "C0694878#ent", "<e2>", "and", "HCV", ",", "and", "12", "patients", "had", "C0275524#ent", "<e1>", "C0694878#ent", "<e2>", "and", "HGV", "."], "h": {"id": "C0694878", "name": "C0694878#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [3, 4]}}
{"token": ["It", "was", "markedly", "(", "p", "less", "than", "0.05", ")", "attenuated", "both", "by", "C0021246#ent", "<e1>", "and", "acetylsalicylic", "acid", "pretreatments", "indicating", "an", "imbalance", "among", "the", "vasoactive", "prostanoids", "C0011849#ent", "<e2>", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [25, 26]}}
{"token": ["Transient-transfection", "analysis", "showed", "that", "promoters", "of", "both", "HVP", "and", "RhEBV", "are", "responsive", "to", "C3641847#ent", "<e1>", "and", "that", "they", "bind", "C3889252#ent", "<e2>", "and", "CBF2", "in", "gel", "mobility", "shift", "assays"], "h": {"id": "C3641847", "name": "C3641847#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3889252", "name": "C3889252#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "the", "human", "C1705470#ent", "<e1>", "rise", "to", "an", "inherited", "photosensitive", "disorder", "xeroderma", "pigmentosum", "XP", ")", "associated", "with", "C1333359#ent", "<e2>", "XP-G/CS", ")", "."], "h": {"id": "C1705470", "name": "C1705470#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333359", "name": "C1333359#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "an", "induction", "of", "inducible", "C1705516#ent", "<e1>", "(", "NOS-II", ")", "was", "found", "after", "C1332408#ent", "<e2>", "treatment", "."], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332408", "name": "C1332408#ent", "pos": [15, 16]}}
{"token": ["NMDA", "neurotoxicity", ",", "which", "is", "mediated", ",", "in", "part", ",", "by", "formation", "of", "nitric", "oxide", "NO", ")", "via", "activation", "of", "neuronal", "NO", "synthase", "C1705516#ent", "<e1>", ")", ",", "is", "modulated", "by", "C1332408#ent", "<e2>", "."], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1332408", "name": "C1332408#ent", "pos": [30, 31]}}
{"token": ["We", "conclude", "that", "activation", "of", "C1705516#ent", "<e1>", "is", "a", "pathological", "consequence", "of", "C1332408#ent", "<e2>", "application", ",", "which", "reduces", "its", "neuroprotective", "potential"], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332408", "name": "C1332408#ent", "pos": [12, 13]}}
{"token": ["Patients", "with", "this", "C1848862#ent", "<e1>", "do", "not", "have", "a", "history", "of", "head", "trauma", "C1254351#ent", "<e2>", "or", "alcohol", "intoxication", "hypoglycemia", "or", "psychologic", "dysfunction"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}}
{"token": ["Although", "the", "deduced", "amino", "acid", "of", "the", "delta", "and", "beta", "subunits", "some", "conserved", "regions", "with", "the", "corresponding", "C1305923#ent", "<e1>", "of", "other", "[", "NiFe", "]", "C0030016#ent", "<e2>", ",", "the", "overall", "amino", "acid", "homology", "is", "marginal", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [24, 25]}}
{"token": ["Neoplastic", "C0669372#ent", "<e1>", "were", "less", "sensitive", "to", "lindane", "and", "C0025677#ent", "<e2>", ",", "did", "not", "differ", "in", "cytotoxic", "response", "diethylnitrosamine", "and", "adriamycin", "and", "were", "more", "sensitive", "to", "cycloheximide", "compared", "to", "normal", "mouse", "C0669372#ent", "<e1>", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [9, 10]}}
{"token": ["N-terminal", "sequencing", "subsequent", "screening", "of", "a", "genomic", "library", "T.", "scotoductus", "revealed", "an", "ORF", "of", "1386", "bp", ",", "C1334043#ent", "<e1>", "(", "84", "%", ")", "to", "the", "C1414063#ent", "<e2>", "Thermus", "thermophilus", "HB8"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414063", "name": "C1414063#ent", "pos": [25, 26]}}
{"token": ["The", "structure", "of", "the", "NADPH", "domain", "probably", "C1334043#ent", "<e1>", "with", "the", "NAD", "domain", "C1414063#ent", "<e2>", "with", "the", "FAD", "domain", "several", "proteins", ",", "but", "not", "with", "NADPH", "domains", "known", "chain-fold", "in", "other", "proteins", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414063", "name": "C1414063#ent", "pos": [13, 14]}}
{"token": ["Each", "modality", "decreases", "C0003850#ent", "<e1>", "in", "animal", "models", "and", "C0215147#ent", "<e2>", "decreases", "human", "coronary", "luminal", "stenosis"], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0215147", "name": "C0215147#ent", "pos": [9, 10]}}
{"token": ["Circulatory", "depression", "treatment", "with", "vasopressor", "or", "C0242896#ent", "<e1>", "more", "common", "in", "patients", "given", "C0042435#ent", "<e2>", "."], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042435", "name": "C0042435#ent", "pos": [13, 14]}}
{"token": ["Two", "C0751984#ent", "<e1>", "the", "products", "of", "C0017337#ent", "<e2>", "6.7", "and", "7.3", ",", "also", "are", "ejected", "from", "the", "infecting", "virion", "."], "h": {"id": "C0751984", "name": "C0751984#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}}
{"token": ["We", "show", "that", "the", "C3642427#ent", "<e1>", "AN2690", ")", ",", "in", "development", "for", "the", "treatment", "of", "C0040261#ent", "<e2>", ",", "inhibits", "yeast", "cytoplasmic", "leucyl-tRNA", "synthetase", "formation", "of", "a", "stable", "tRNA(Leu)-AN2690", "adduct", "in", "the", "editing", "site", "the", "enzyme", "."], "h": {"id": "C3642427", "name": "C3642427#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0040261", "name": "C0040261#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "we", "report", "development", "of", "Ad", "vectors", "incorporate", "tTS", "in", "combination", "with", "that", "of", "reverse", "transactivator", "C0035372#ent", "<e1>", ")", "coupled", "with", "C1421114#ent", "<e2>", "promoter", "driving", "transgene", "expression", "."], "h": {"id": "C0035372", "name": "C0035372#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [22, 23]}}
{"token": ["A", "binary", "HIV-1-based", "vector", "system", "consisting", "of", "a", "lentivirus", "encoding", "C0035372#ent", "<e1>", "and", "a", "second", "lentivirus", "harboring", "a", "C1421114#ent", "<e2>", "driving", "the", "EGFP", "reporter", "gene", "also", "designed", "."], "h": {"id": "C0035372", "name": "C0035372#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [18, 19]}}
{"token": ["Anaemia", "in", "three", "patients", "with", "C0021390#ent", "<e1>", "responded", "in", "8", "-", "14", "weeks", "to", "C0376541#ent", "<e2>", "and", "two", "of", "the", "three", "reached", "normal", "haemoglobin", "levels"], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0376541", "name": "C0376541#ent", "pos": [14, 15]}}
{"token": ["Hepatic", "activity", "type", "I", "deiodinase", "decreased", "and", "C1259497#ent", "<e1>", "increased", "after", "C1539862#ent", "<e2>", "treatment", "."], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539862", "name": "C1539862#ent", "pos": [11, 12]}}
{"token": ["A", "2-year-old", "amerasian", "male", "with", "anhidrotic", "ectodermal", "dysplasia", "C0162359#ent", "<e1>", "was", "admitted", "for", "C0085543#ent", "<e2>", "Mycobacteria", "avium-intracellulare", "infection", "."], "h": {"id": "C0162359", "name": "C0162359#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [13, 14]}}
{"token": ["C0041491#ent", "<e1>", "activation", "by", "histamine", "was", "unaffected", "by", "the", "protein", "kinase", "C", "inhibitor", "C2987048#ent", "<e2>", "31", "-", "8220", "but", "was", "completely", "blocked", "by", "the", "protein", "kinase", "A", "inhibitor", "H89", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987048", "name": "C2987048#ent", "pos": [13, 14]}}
{"token": ["The", "responsible", "bacterial", "pathogens", "differ", "between", "C0694549#ent", "<e1>", "and", "nosocomial", "aspiration", "C0032285#ent", "<e2>", "."], "h": {"id": "C0694549", "name": "C0694549#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [11, 12]}}
{"token": ["This", "microorganism", "is", "a", "common", "cause", "(", "10", "-", "30", "%", ")", "of", "C0694549#ent", "<e1>", "also", "called", "primary", "atypical", "C0032285#ent", "<e2>", "because", "of", "the", "spectrum", "of", "clinical", "and", "radiological", "findings", "."], "h": {"id": "C0694549", "name": "C0694549#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [19, 20]}}
{"token": ["The", "interactions", "of", "the", "C3536711#ent", "<e1>", "Heparin", "with", "the", "alpha-2-adrenoceptor", "in", "rat", "C0001614#ent", "<e2>", "membranes", "were", "investigated", "."], "h": {"id": "C3536711", "name": "C3536711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [12, 13]}}
{"token": ["In", "Pilgrimage", ",", "an", "infant", "(", "1.9", "%", ")", "had", "congenital", "malaria", "17", "cases", "(", "32.1", "%", ")", "had", "severe", "C0024530#ent", "<e1>", "and", "2", "(", "3.8", "%", ")", "died", "by", "C0024534#ent", "<e2>"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [20, 21]}, "relation": "nichd_parent_of", "t": {"id": "C0024534", "name": "C0024534#ent", "pos": [30, 31]}}
{"token": ["Among", "the", "2488", "diagnosed", "C0024530#ent", "<e1>", "patients", ",", "4.4", "%", "fulfilled", "the", "WHO", "criteria", "for", "severe", "C0024530#ent", "<e1>", ",", "and", "seven", "died", "of", "C0024534#ent", "<e1>"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0024534", "name": "C0024534#ent", "pos": [23, 24]}}
{"token": ["The", "68", "kDa", "Src", "substrate", "associated", "during", "mitosis", "(", "C1425322#ent", "<e1>", ")", "is", "an", "C1826636#ent", "<e2>", "Src", "homology", "SH", ")", "2", "and", "3", "domain", "binding", "sites", "."], "h": {"id": "C1425322", "name": "C1425322#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826636", "name": "C1826636#ent", "pos": [14, 15]}}
{"token": ["C1425322#ent", "<e1>", "is", "an", "C1826636#ent", "<e2>", "is", "tyrosine-phosphorylated", "by", "Src", "during", "mitosis", "and", "has", "been", "postulated", "to", "have", "a", "role", "in", "cell", "cycle", "control", "modulating", "RNA", "metabolism"], "h": {"id": "C1425322", "name": "C1425322#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1826636", "name": "C1826636#ent", "pos": [4, 5]}}
{"token": ["The", "vector", "was", "modified", "by", "the", "introduction", "of", "a", "DNA", "fragment", "the", "C0079941#ent", "<e1>", "the", "C.", "perfringens", "chloramphenicol", "C0001068#ent", "<e2>", "flanking", "transcriptional", "terminators"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001068", "name": "C0001068#ent", "pos": [18, 19]}}
{"token": ["A", "synergistic", "effect", "C3539598#ent", "<e1>", ",", "CAZ", ",", "and", "C0004135#ent", "<e2>", "was", "detected", "for", "1.5", "%", "of", "all", "strains", ",", "mainly", "those", "of", "Klebsiella", "pneumoniae", "13.3", "%", ")", "."], "h": {"id": "C3539598", "name": "C3539598#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [9, 10]}}
{"token": ["The", "antiproliferative", "activity", "C0065175#ent", "<e1>", ",", "alone", "or", "in", "combination", "with", "the", "C0039286#ent", "<e2>", "was", "studied", "on", "estrogen", "receptor-positive", "estrogen", "receptor-negative", "breast", "cancer", "cell", "lines"], "h": {"id": "C0065175", "name": "C0065175#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [12, 13]}}
{"token": ["Complementing", "the", "genetic", "associations", "we", "also", "detected", "a", "distinct", "regional", "expression", "regulation", "CCL2", ",", "C1332692#ent", "<e1>", "and", "CCL8", "in", "correlation", "with", "chronic", "inflammation", "C1417325#ent", "<e2>", "brains", "."], "h": {"id": "C1332692", "name": "C1332692#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [23, 24]}}
{"token": ["Coexpression", "of", "cytokeratins", "with", "C1421451#ent", "<e1>", "appears", "to", "occur", "C0907533#ent", "<e2>", "in", "follicular", "epithelial", "cells", "normal", "thyroid", "gland", "is", "also", "frequent", "in", "the", "diverse", "carcinomas", ",", "though", "to", "various", "degrees", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}}
{"token": ["Both", "C0010803#ent", "<e1>", "were", "inhibited", "by", "C0031493#ent", "<e2>", "suggests", "a", "serine", "residue", "or", "near", "an", "active", "site"], "h": {"id": "C0010803", "name": "C0010803#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031493", "name": "C0031493#ent", "pos": [6, 7]}}
{"token": ["C0163410#ent", "<e1>", "GCS", ")", ",", "the", "C0014442#ent", "<e2>", "that", "converts", "ceramide", "to", "glucosylceramide", ",", "induce", "multidrug", "resistance", "MDR", ")", "in", "cancer", "cells"], "h": {"id": "C0163410", "name": "C0163410#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}}
{"token": ["To", "date", ",", "only", "five", "C0268136#ent", "<e1>", "patients", "with", "three", "different", "mutations", "in", "the", "C1333357#ent", "<e2>", "been", "reported", "."], "h": {"id": "C0268136", "name": "C0268136#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1333357", "name": "C1333357#ent", "pos": [14, 15]}}
{"token": ["This", "article", "describes", "several", "well", "defined", "electro-clinical", "entities", ":", "C1142166#ent", "<e1>", "torsades", "de", "pointes", "a", "short", "coupling", "interval", ",", "C1631597#ent", "<e2>", "the", "acquired", "long", "QT", "syndrome", "."], "h": {"id": "C1142166", "name": "C1142166#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1631597", "name": "C1631597#ent", "pos": [19, 20]}}
{"token": ["Pentobarbital", "calibrator", "were", "substituted", "for", "the", "C0036516#ent", "<e1>", "with", "the", "assay", "kit", "and", "control", "solutions", "C0030883#ent", "<e2>", "were", "used", "to", "determine", "the", "modified", "assay", "'s", "precision", "and", "accuracy", "."], "h": {"id": "C0036516", "name": "C0036516#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [15, 16]}}
{"token": ["A", "general", "method", "the", "analysis", "of", "barbiturates", ",", "using", "column", "parition", "chromatography", "was", "extended", "to", "the", "assay", "of", "C0036516#ent", "<e1>", ",", "amobarbital", ",", "and", "C0030883#ent", "<e2>", "."], "h": {"id": "C0036516", "name": "C0036516#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [24, 25]}}
{"token": ["C0343055#ent", "<e1>", "PPP", ")", "is", "a", "C1290886#ent", "<e2>", "mainly", "smoking", "women", "."], "h": {"id": "C0343055", "name": "C0343055#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1290886", "name": "C1290886#ent", "pos": [6, 7]}}
{"token": ["Ultrafiltration", "was", "adopted", "in", "two", "different", "modes", "followed", "by", "monitoring", "of", "polyvinyl", "alcohol", "PVA", ")", ",", "C0079224#ent", "<e1>", "DS", ")", ",", "and", "C0023992#ent", "<e2>", "HCl", "contents", "."], "h": {"id": "C0079224", "name": "C0079224#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023992", "name": "C0023992#ent", "pos": [22, 23]}}
{"token": ["Myocardial", "disease", "predominantly", "as", "cardiomyopathy", "and", "C0018802#ent", "<e1>", "characteristic", "of", "C0013264#ent", "<e2>", "and", "Becker", "muscular", "dystrophies", "X-linked", "dilated", "cardiomyopathy", "whereas", "conduction", "system", "that", "cause", "heart", "block", "arrhythmias", ",", "and", "sudden", "death", "more", "commonly", "seen", "in", "limb-girdle", "type", "1B", "myotonic", ",", "and", "Emery-Dreifuss", "muscular", "dystrophies"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0013264", "name": "C0013264#ent", "pos": [10, 11]}}
{"token": ["C0242518#ent", "<e1>", "(", "Torecan", ")", "is", "a", "piperazine", "phenothiazine", "to", "relieve", "C0042571#ent", "<e2>", "."], "h": {"id": "C0242518", "name": "C0242518#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042571", "name": "C0042571#ent", "pos": [11, 12]}}
{"token": ["The", "same", "assay", "was", "used", "as", "before", "in", "demonstrating", "deficiency", "of", "this", "enzyme", "activity", "cerebrotendinous", "xanthomatosis", "C1413864#ent", "<e1>", ")", ",", "a", "disease", "in", "which", "high", "excretion", "of", "C0001975#ent", "<e2>", "typical", "."], "h": {"id": "C1413864", "name": "C1413864#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [27, 28]}}
{"token": ["C1413864#ent", "<e1>", "proved", "by", "a", "greatly", "increased", "excretion", "of", "C0001975#ent", "<e2>", "the", "patient's", "urine", "."], "h": {"id": "C1413864", "name": "C1413864#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [9, 10]}}
{"token": ["But", "her", "C0003862#ent", "<e1>", ",", "which", "had", "been", "relieved", "by", "C0728960#ent", "<e2>", "after", "admission", ",", "was", "worsened", "if", "she", "took", "prednisolone", "without", "analgesic", "."], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [10, 11]}}
{"token": ["Grade", "3/4", "neutropenia", "was", "seen", "in", "13", "%", "of", "courses", ",", "peripheral", "neuropathy", "myalgia", "and", "C0003862#ent", "<e1>", "were", "frequent", ",", "but", "transitory", "and", "relieved", "with", "C0728960#ent", "<e2>", "."], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [25, 26]}}
{"token": ["In", "contrast", "to", "C0068700#ent", "<e1>", ",", "the", "effect", "of", "C0051696#ent", "<e2>", "was", "more", "prominent", "in", "the", "distal", "compared", "to", "the", "proximal", "vessel", "rings", "."], "h": {"id": "C0068700", "name": "C0068700#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "C0537298#ent", "<e1>", "a", "neutral", "endonuclease", "required", "both", "Ca2", "+", "and", "C1333909#ent", "<e2>", "+", "for", "full", "activity", "and", "was", "inhibited", "by", "Zn2+"], "h": {"id": "C0537298", "name": "C0537298#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggested", "that", "binding", "of", "a", "protein", "transcription", ")", "such", "as", "C0026900#ent", "<e1>", "or", "that", "alike", "regulates", "transcription", "of", "the", "C1418894#ent", "<e2>", "binding", "to", "a", "small", "upstream", "region"], "h": {"id": "C0026900", "name": "C0026900#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418894", "name": "C1418894#ent", "pos": [21, 22]}}
{"token": ["C4085193#ent", "<e1>", "is", "a", "C1420102#ent", "<e2>", "is", "specifically", "expressed", "on", "the", "basolateral", "membrane", "retinal", "pigment", "epithelial", "cells", "(", "RPE", ")", "."], "h": {"id": "C4085193", "name": "C4085193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420102", "name": "C1420102#ent", "pos": [4, 5]}}
{"token": ["A", "total", "of", "49", "patients", "with", "C0010054#ent", "<e1>", "38", "of", "whom", "had", "previously", "survived", "C1423951#ent", "<e2>", "dial", "infarction", "were", "treated", "with", "Piridoxylate", "administered", "intramuscularly", "and", "orally", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423951", "name": "C1423951#ent", "pos": [14, 15]}}
{"token": ["In", "cattle", ",", "C0851341#ent", "<e1>", "with", "P.", "ovis", "responsible", "for", "a", "severe", "C0011603#ent", "<e2>", "."], "h": {"id": "C0851341", "name": "C0851341#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011603", "name": "C0011603#ent", "pos": [12, 13]}}
{"token": ["However", ",", "we", "exclude", "caspases", ",", "calpains", ",", "and", "C0699919#ent", "<e1>", "as", "potential", "C2717970#ent", "<e2>", "in", "the", "17beta-E2-mediated", "Csp-6", "inhibition", "."], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [13, 14]}}
{"token": ["While", "studying", "mitosis", "in", "Dictyostelium", "mutants", "deficiencies", "in", "actin-binding", "proteins", "we", "found", "that", "two", "of", "these", "C0086376#ent", "<e1>", ",", "cortexillin", "and", "C3812153#ent", "<e2>", ",", "are", "required", "for", "the", "precise", "segregation", "of", "chromosomes", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3812153", "name": "C3812153#ent", "pos": [21, 22]}}
{"token": ["One", "patient", "harbored", "a", "mutation", "in", "the", "second", "exon", "of", "C0079975#ent", "<e1>", "and", "two", "patients", "in", "the", "second", "exon", "of", "C1537502#ent", "<e2>", "."], "h": {"id": "C0079975", "name": "C0079975#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [20, 21]}}
{"token": ["Activating", "mutations", "of", "RAS", "genes", "C1537502#ent", "<e1>", "or", "C0079975#ent", "<e2>", ")", "and", "overexpression", "of", "C1537502#ent", "<e1>", "were", "mutually", "exclusive", "events", "."], "h": {"id": "C0079975", "name": "C0079975#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [5, 6]}}
{"token": ["Any", "pathological", "disorders", "C2712370#ent", "<e1>", "the", "renal", "blood", "flow", "results", "in", "two", "consequences", ":", "renovascular", "hypertension", "C1565489#ent", "<e2>"], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565489", "name": "C1565489#ent", "pos": [16, 17]}}
{"token": ["C2697954#ent", "<e1>", "hyperphosphorylation", "was", "accompanied", "by", "decreases", "in", "C1332803#ent", "<e2>", "phosphorylation", "and", "increases", "in", "nuclear", "translocation", "C1332803#ent", "<e2>", "."], "h": {"id": "C2697954", "name": "C2697954#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [8, 9]}}
{"token": ["While", "C0297959#ent", "<e1>", "B", "show", "potent", "C0003392#ent", "<e2>", "in", "vitro", "these", "effects", "were", "not", "seen", "in", "preclinical", "in", "vivo", "models", "due", "to", "their", "poor", "metabolic", "stability", "unfavorable", "pharmacokinetics", "."], "h": {"id": "C0297959", "name": "C0297959#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [6, 7]}}
{"token": ["Both", "newly", "detected", "TSC", "C1784", "T", "and", "C1439274#ent", "<e1>", "T727C", "are", "gene", "polymorphisms", "susceptible", "to", "the", "C0003364#ent", "<e2>", "TZDs", "in", "patients", "with", "EHT", "."], "h": {"id": "C1439274", "name": "C1439274#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [16, 17]}}
{"token": ["Using", "co-sedimentation", "and", "co-immunoprecipitation", "we", "have", "defined", "a", "macromolecular", "complex", "of", "C1419779#ent", "<e1>", ",", "FKBP12.6", ",", "PKA", ",", "the", "C0031686#ent", "<e2>", "PP1", "and", "PP2A", ",", "and", "an", "anchoring", "protein", "mAKAP", "."], "h": {"id": "C1419779", "name": "C1419779#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [19, 20]}}
{"token": ["C1334081#ent", "<e1>", "was", "also", "effective", "in", "reducing", "the", "maximal", "electroshock", "C4283758#ent", "<e2>", ")", "induced", "convulsive", "time", "this", "protective", "effect", "blocked", "by", "PI-3", "kinase", "inhibitors"], "h": {"id": "C1334081", "name": "C1334081#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4283758", "name": "C4283758#ent", "pos": [10, 11]}}
{"token": ["When", "a", "dominant-negative", "C1419210#ent", "<e1>", "mutant", "or", "a", "C0907533#ent", "<e2>", "active", "GTP-bound", "Rab6a", "protein", "was", "overexpressed", "in", "prion-infected", "neuroblastoma", "N2a", "cells", "there", "was", "a", "marked", "increase", "of", "PrP(Sc", ")", "formation", "."], "h": {"id": "C1419210", "name": "C1419210#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}}
{"token": ["The", "hydrolytic", "activity", "inhibited", "by", "the", "serine", "protease", "inhibitors", "diisopropyl", "fluorophosphate", "DFP", ")", ",", "aprotinin", ",", "antipain", "and", "C0064858#ent", "<e1>", ",", "but", "not", "by", "chymostatin", ",", "a", "C0072409#ent", "<e2>"], "h": {"id": "C0064858", "name": "C0064858#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0072409", "name": "C0072409#ent", "pos": [27, 28]}}
{"token": ["Endogenous", "C0593802#ent", "<e1>", "end-NOSIs", ")", "have", "been", "associated", "with", "cardiovascular", "risk", "factors", "C0004153#ent", "<e2>", "."], "h": {"id": "C0593802", "name": "C0593802#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "do", "no", "support", "an", "association", "between", "particulate", "matter", "increased", "risk", "of", "C0018790#ent", "<e1>", "persons", "without", "clinically", "recognized", "C0018799#ent", "<e2>"], "h": {"id": "C0018790", "name": "C0018790#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [19, 20]}}
{"token": ["Interaction", "of", "C1522670#ent", "<e1>", "(", "UK", ")", "activated", "plasmin", "with", "C0040613#ent", "<e2>", "alpha", "2", "plasmin", "inhibitor", "alpha", "2PI", ")", "was", "studied", "by", "using", "a", "chromogenic", "substrate", "(", "S-2251", ")", "and", "immunoelectrophoresis", "."], "h": {"id": "C1522670", "name": "C1522670#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040613", "name": "C0040613#ent", "pos": [10, 11]}}
{"token": ["The", "plasma", "pentosidine", "level", "may", "be", "useful", "for", "the", "early", "diagnosis", "C0035078#ent", "<e1>", "to", "estimate", "the", "degree", "of", "the", "severity", "of", "C0022658#ent", "<e2>"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [21, 22]}}
{"token": ["In", "another", "case", "we", "determined", "that", "C0042571#ent", "<e1>", "occurring", "after", "stapedectomy", "was", "not", "related", "to", "concomitant", "C0032541#ent", "<e2>"], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032541", "name": "C0032541#ent", "pos": [16, 17]}}
{"token": ["These", "transient", "acute", "cranial", "nerve", "findings", "in", "patients", "with", "C0042571#ent", "<e1>", "the", "concept", "of", "C0032541#ent", "<e2>", "and", "preliminary", "studies", "indicate", "that", "an", "anti-inflammatory", "agent", "as", "prednisone", "may", "be", "the", "preferred", "treatment", "."], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032541", "name": "C0032541#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "report", "the", "effect", "of", "site-directed", "mutations", "the", "context", "of", "the", "whole", "PML", "protein", "of", "C3539946#ent", "<e1>", "on", "the", "surface", "of", "the", "C0023524#ent", "<e2>", "RING", "finger", "domain", "C0023524#ent", "<e2>", "NB", "formation", "in", "vivo"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [24, 25]}}
{"token": ["Zinc", "finger", "protein", "423", "also", "known", "as", "C3540499#ent", "<e1>", "Ebfaz", ")", "binds", "to", "and", "negatively", "regulates", "C2699988#ent", "<e2>", ",", "a", "basic", "helix-loop-helix", "transcription", "factor", "for", "B-cell", "lineage", "commitment", "and", "olfactory", "epithelium", "development", "."], "h": {"id": "C3540499", "name": "C3540499#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2699988", "name": "C2699988#ent", "pos": [16, 17]}}
{"token": ["Decay-accelerating", "factor", "C3272447#ent", "<e1>", ")", "is", "a", "widely", "expressed", ",", "C0536221#ent", "<e2>", "in", "complement", "regulation", "cell", "signaling"], "h": {"id": "C3272447", "name": "C3272447#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [10, 11]}}
{"token": ["C0241518#ent", "<e1>", "a", "significant", "sequela", "of", "C0029883#ent", "<e2>", "and", "has", "been", "linked", "clinically", "to", "atelectasis", ",", "ossicular", "erosion", "and", "cholesteatoma", "."], "h": {"id": "C0241518", "name": "C0241518#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029883", "name": "C0029883#ent", "pos": [6, 7]}}
{"token": ["Truncated", "C0243601#ent", "<e1>", "is", "expressed", "as", "an", "active", "C0027203#ent", "<e2>", "with", "characteristics", "typical", "of", "an", "FMO", "isoform", "."], "h": {"id": "C0243601", "name": "C0243601#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["To", "date", "two", "C1417679#ent", "<e1>", "are", "known", "to", "be", "involved", "in", "variant", "LINCL", ",", "C1850442#ent", "<e2>", "and", "CLN6", ",", "which", "map", "to", "chromosomes", "13q21", "15q21-23"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1850442", "name": "C1850442#ent", "pos": [14, 15]}}
{"token": ["Employing", "the", "hot", "plate", "test", "determine", "the", "entity", "of", "a", "central", "analgesic", "response", ",", "the", "C0021171#ent", "<e1>", "administration", "of", "calcitonin", "surprisingly", "revealed", "a", "C0728960#ent", "<e2>", "effect", "."], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [23, 24]}}
{"token": ["The", "chromosomal", "localization", "the", "chicken", "transferrin", "receptor", "gene", "as", "well", "as", "sequences", "that", "were", "homologous", "to", "the", "C0087140#ent", "<e1>", "the", "human", "gene", "families", "C1421579#ent", "<e2>", "and", "SRY", "were", "determined", "by", "the", "method", "of", "nonisotopic", "DNA-DNA", "in", "situ", "hybridization"], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1421579", "name": "C1421579#ent", "pos": [23, 24]}}
{"token": ["Knock", "down", "of", "C1367307#ent", "<e1>", "by", "short", "interfering", "RNA", "C1367307#ent", "<e1>", "activation", "and", "C3273731#ent", "<e1>", "induction", "by", "IFN-gamma", "in", "Stat1-/-", "fibroblasts", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273731", "name": "C3273731#ent", "pos": [13, 14]}}
{"token": ["These", "data", "suggest", "that", "hyperactivation", "of", "C1367307#ent", "<e1>", "results", "in", "severe", "colitis", "and", "that", "C3273731#ent", "<e2>", "plays", "a", "negative", "regulatory", "role", "in", "intestinal", "inflammation", "by", "downregulating", "C1367307#ent", "<e1>", "activity", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273731", "name": "C3273731#ent", "pos": [14, 15]}}
{"token": ["Acute", "otitis", "media", "AOM", ")", "is", "one", "of", "the", "most", "common", "C0679247#ent", "<e1>", "for", "which", "children", "in", "the", "United", "States", "an", "C1136254#ent", "<e2>"], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [21, 22]}}
{"token": ["The", "Saccharomyces", "cerevisiae", "transcription", "factor", "IIH", "TFIIH", ")", "is", "essential", "both", "for", "transcription", "by", "C0035680#ent", "<e1>", "RNAP", "II", "and", "for", "nucleotide", "excision", "repair", "C1417823#ent", "<e2>", ")", "of", "damaged", "DNA", "."], "h": {"id": "C0035680", "name": "C0035680#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417823", "name": "C1417823#ent", "pos": [23, 24]}}
{"token": ["The", "likely", "explanation", "for", "our", "results", "is", "a", "common", "C0017361#ent", "<e1>", "genetic", "variant", "in", "or", "near", "the", "C2986859#ent", "<e2>", "which", ",", "when", "homozygous", ",", "conveys", "an", "increased", "risk", "of", "breast", "cancer"], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2986859", "name": "C2986859#ent", "pos": [17, 18]}}
{"token": ["The", "purified", "C0027203#ent", "<e1>", "had", "optimal", "activity", "at", "pH", "6", "and", "no", "C2827312#ent", "<e2>", "requirements", ",", "and", "was", "inhibited", "by", "the", "serine", "active", "site", "phenylmethylsulfonyl", "fluoride", "by", "free", "sulfhydryl", "specific", "reagents", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2827312", "name": "C2827312#ent", "pos": [12, 13]}}
{"token": ["Cholesterol", "7", "alpha-hydroxylase", "the", "rate-limiting", "C0027203#ent", "<e1>", "in", "the", "bile", "acid", "synthesis", ",", "is", "down-regulated", "by", "C2827312#ent", "<e2>", "by", "way", "of", "negative", "feedback", "control", "at", "the", "level", "of", "gene", "transcription"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2827312", "name": "C2827312#ent", "pos": [16, 17]}}
{"token": ["To", "determine", "the", "prevalence", "of", "antiphospholipid", "antibodies", "other", "immunologic", "abnormalities", "patients", "with", "C0035326#ent", "<e1>", "exempt", "from", "conventional", "risk", "factors", "C0035328#ent", "<e2>"], "h": {"id": "C0035326", "name": "C0035326#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035328", "name": "C0035328#ent", "pos": [19, 20]}}
{"token": ["We", "also", "provided", "preliminary", "evidence", "that", "the", "deletion", "of", "the", "nontranslocated", "TEL", "C1706112#ent", "<e1>", "may", "adversely", "influence", "the", "clinical", "course", "C0919449#ent", "<e2>", "ALL", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0919449", "name": "C0919449#ent", "pos": [20, 21]}}
{"token": ["This", "fragment", "may", "be", "activated", "to", "yield", "another", "proteinase", ",", "that", "splits", "preferentially", "laminin", "and", "denatured", "collagen", "type", "I.", "This", "C0027203#ent", "<e1>", "will", "be", "referred", "as", "C0082578#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0082578", "name": "C0082578#ent", "pos": [26, 27]}}
{"token": ["C0016514#ent", "<e1>", "FMDV", ")", "to", "type", "O1", "K", "was", "treated", "with", "C0036734#ent", "<e2>", "of", "differing", "specificity", "."], "h": {"id": "C0016514", "name": "C0016514#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [11, 12]}}
{"token": ["To", "obtain", "good", "sensitivity", "the", "use", "of", "the", "right", "mobile", "phase", "very", "important", ":", "ammonium", "acetate", "C0001962#ent", "<e1>", "in", "the", "case", "of", "C0117339#ent", "<e2>", "and", "its", "metabolites", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0117339", "name": "C0117339#ent", "pos": [22, 23]}}
{"token": ["The", "low", "concentration", "of", "C1412332#ent", "<e1>", "and", "the", "characteristic", "protein", "26", "kD", "in", "the", "C1260880#ent", "<e2>", "appeared", "to", "differentiate", "patients", "with", "non-allergic", "chronic", "rhinosinusitis", "those", "with", "perennial", "allergic", "rhinitis"], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [14, 15]}}
{"token": ["Eighty-eight", "percent", "of", "duodenal", "ulcers", "73", "percent", "of", "C0038358#ent", "<e1>", "healed", "with", "six", "weeks", "of", "C0038633#ent", "<e2>", "treatment", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0038633", "name": "C0038633#ent", "pos": [15, 16]}}
{"token": ["A", "double-blind", ",", "randomized", "study", "the", "healing", "of", "C0038358#ent", "<e1>", "a", "twice-daily", "regimen", "of", "2", "g", "C0038633#ent", "<e2>", "or", "400", "mg", "cimetidine", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0038633", "name": "C0038633#ent", "pos": [16, 17]}}
{"token": ["Overexpression", "of", "FLAP", "did", "not", "alter", "Bcl-xL", "protein", "expression", ",", "but", "did", "decrease", "C0812198#ent", "<e1>", "somewhat", "increased", "C1415652#ent", "<e2>", "and", "COX-2", "mRNA", "levels", "."], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [17, 18]}}
{"token": ["The", "toxicity", "was", "prevented", "by", "inhibitors", "of", "C0001942#ent", "<e1>", "augmented", "by", "the", "C3850110#ent", "<e2>", "disulfiram", ",", "suggesting", "that", "the", "toxic", "metabolite", "the", "reactive", "aldehyde", "acrolein", "."], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3850110", "name": "C3850110#ent", "pos": [12, 13]}}
{"token": ["This", "report", "describes", "a", "patient", "with", "C0030567#ent", "<e1>", "who", "was", "on", "a", "multiple", "drug", "regimen", "low", "dose", "C0107994#ent", "<e2>", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0107994", "name": "C0107994#ent", "pos": [17, 18]}}
{"token": ["In", "these", "cases", ",", "testing", "alternate", "C0003864#ent", "<e1>", "to", "be", "useful", "to", "identify", "C3826857#ent", "<e2>", "effects", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3826857", "name": "C3826857#ent", "pos": [13, 14]}}
{"token": ["Nitrobenzylthioinosine", ",", "a", "transport", "inhibitor", "adenosine", ",", "blocks", "(", "by", "50", "%", ")", "the", "effect", "of", "the", "nucleoside", "on", "C1706611#ent", "<e1>", "formation", "and", "C0017932#ent", "<e2>", "not", "on", "phosphorylase", "."], "h": {"id": "C1706611", "name": "C1706611#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017932", "name": "C0017932#ent", "pos": [23, 24]}}
{"token": ["A", "comparison", "of", "the", "tryptic-chymotryptic", "peptides", "of", "the", "parental", ",", "variant", "and", "C0035379#ent", "<e1>", "heavy", "and", "C0238239#ent", "<e2>", "not", "reveal", "any", "differences", "."], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0238239", "name": "C0238239#ent", "pos": [16, 17]}}
{"token": ["Prostaglandin", "E2", "16", "-", "C0000139#ent", "<e1>", "both", "are", "EP1", ",", "EP2", ",", "C1419063#ent", "<e2>", "and", "EP4", "receptor", "agonists", "."], "h": {"id": "C0000139", "name": "C0000139#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419063", "name": "C1419063#ent", "pos": [12, 13]}}
{"token": ["This", "information", "was", "used", "to", "identify", "C0031727#ent", "<e1>", "that", "are", "potentially", "regulated", "following", "C1422563#ent", "<e2>", "stimulation", ",", "with", "a", "focus", "on", "C1422563#ent", "<e2>", "regulation", "of", "the", "ERK1/2", "MAPK", "pathway", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422563", "name": "C1422563#ent", "pos": [13, 14]}}
{"token": ["The", "conversion", "of", "allopurinol", "to", "oxipurinol", "during", "an", "allopurinol", "loading", "test", "determining", "the", "type", "of", "C0268118#ent", "<e1>", "that", "the", "patients", "had", "C0220988#ent", "<e2>", "because", "aldehyde", "oxidase", "activity", "present", "."], "h": {"id": "C0268118", "name": "C0268118#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0220988", "name": "C0220988#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "recombinant", "C1418302#ent", "<e1>", "in", "which", "all", "19", "C1861303#ent", "<e2>", "codons", "had", "been", "converted", "to", "a", "universal", "serine", "codon", "overexpressed", "in", "Escherichia", "coli", "BL21(DE3", ")", "."], "h": {"id": "C1418302", "name": "C1418302#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1861303", "name": "C1861303#ent", "pos": [11, 12]}}
{"token": ["The", "65-kDa", "protein", "prevented", "the", "inhibitory", "effect", "of", "C1413078#ent", "<e1>", "on", "the", "ATP-dependent", "interaction", "between", "actin", "and", "C0949646#ent", "<e2>", "."], "h": {"id": "C1413078", "name": "C1413078#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0949646", "name": "C0949646#ent", "pos": [17, 18]}}
{"token": ["Bartonella", "henselae", "infect", "humans", "resulting", "in", "a", "wide", "range", "of", "disease", "syndromes", "C0007361#ent", "<e1>", "fever", "with", "bacteremia", ",", "endocarditis", ",", "bacillary", "angiomatosis", "and", "C0030781#ent", "<e2>", "among", "others", "."], "h": {"id": "C0007361", "name": "C0007361#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030781", "name": "C0030781#ent", "pos": [23, 24]}}
{"token": ["The", "effect", "of", "the", "antihyperglycaemic", "agent", "C0770893#ent", "<e1>", "was", "studied", "on", "gene", "expression", "the", "energy-dependent", "sodium-hexose", "cotransporter", "(", "C1420200#ent", "<e2>", ")", "and", "the", "facilitative", "hexose", "transporters", "GLUT2", "and", "GLUT5", "in", "rat", "intestine", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420200", "name": "C1420200#ent", "pos": [18, 19]}}
{"token": ["Both", "gout", "and", "C0553730#ent", "<e1>", "CPPD", ")", "disease", "are", "significant", "C0029896#ent", "<e2>", "within", "the", "purview", "of", "the", "rheumatologist", "."], "h": {"id": "C0553730", "name": "C0553730#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [10, 11]}}
{"token": ["Specifically", ",", "problems", "in", "differentiating", "diagnosis", "of", "rheumatoid", "arthritis", "arthritis", "psoriatica", "C0553730#ent", "<e1>", ",", "and", "other", "C0029896#ent", "<e2>", "of", "the", "joints", "will", "receive", "special", "mention", "."], "h": {"id": "C0553730", "name": "C0553730#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [16, 17]}}
{"token": ["Biological", "therapies", "revolutionized", "the", "treatment", "of", "C0442893#ent", "<e1>", "which", "the", "C1334156#ent", "<e2>", "a", "part", "of", "the", "disease", "mechanism"], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334156", "name": "C1334156#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "transient", "transfection", "with", "expression", "vectors", "C0079972#ent", "<e1>", "on", "the", "promoter", "activity", "C1412356#ent", "<e2>", "in", "human", "epidermoid", "carcinoma", "cells", "was", "studied", "."], "h": {"id": "C0079972", "name": "C0079972#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412356", "name": "C1412356#ent", "pos": [14, 15]}}
{"token": ["Using", "sulforhodamin", "B", "staining", "to", "assess", "cell", "proliferation", "we", "found", "that", "the", "isothiocyanates", "were", "strongly", "cytotoxic", ",", "whereas", "the", "C0021236#ent", "<e1>", "inhibited", "cell", "growth", "a", "C0072454#ent", "<e2>", "manner", "."], "h": {"id": "C0021236", "name": "C0021236#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0072454", "name": "C0072454#ent", "pos": [25, 26]}}
{"token": ["Authors", "injected", "until", "1989", "in", "92", "patients", "with", "juvenile", "bone", "cyst", "C0600901#ent", "<e1>", "locally", "after", "punction", "of", "the", "C0010709#ent", "<e2>", "."], "h": {"id": "C0600901", "name": "C0600901#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010709", "name": "C0010709#ent", "pos": [18, 19]}}
{"token": ["Severe", "C0878676#ent", "<e1>", "a", "tetrahydrobiopterin", "deficiency", "disorder", "presents", "in", "infancy", "with", "developmental", "delay", "C0036572#ent", "<e2>", ",", "and", "abnormal", "movements", "associated", "with", "hyperphenylalaninemia", "usually", "detectable", "by", "neonatal", "phenylketonuria", "screening", "programs"], "h": {"id": "C0878676", "name": "C0878676#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["Based", "on", "analysis", "of", "all", "the", "cases", "described", "in", "the", "English", "language", "literature", "it", "is", "suggested", "that", "this", "syndrome", "be", "expanded", "to", "include", "C0031069#ent", "<e1>", "rather", "than", "C0003864#ent", "<e2>", "alone", "."], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [27, 28]}}
{"token": ["In", "this", "paper", ",", "we", "describe", "a", "22-year-old", "patient", "with", "C0031069#ent", "<e1>", "who", "was", "complicated", "with", "protracted", "C0003864#ent", "<e2>", "in", "the", "knee", "and", "shoulder", "joints", "bilateral", "sacroiliitis"], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [17, 18]}}
{"token": ["SCTs", "improved", "jejunal", "and", "colonic", "adaptive", "growth", "and", "maintained", "comparable", "nutritional", "status", "C2985249#ent", "<e1>", "when", "compared", "with", "CD", "alone", "or", "CD", "with", "C1420102#ent", "<e2>", "."], "h": {"id": "C2985249", "name": "C2985249#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420102", "name": "C1420102#ent", "pos": [22, 23]}}
{"token": ["To", "evaluate", "the", "pharmacological", "compliance", "of", "patients", "treated", "with", "C0050940#ent", "<e1>", "orally", "disintegrating", "tablets", "(", "LODT", ")", "in", "Primary", "Care", "C1418724#ent", "<e2>", ")", "and", "their", "acceptability", "of", "this", "formulation", "."], "h": {"id": "C0050940", "name": "C0050940#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418724", "name": "C1418724#ent", "pos": [20, 21]}}
{"token": ["Attempts", "to", "phosphorylate", "the", "enzyme", "in", "the", "presence", "of", "C2936886#ent", "<e1>", "were", "unsuccessful", ",", "unless", "the", "C0033607#ent", "<e2>", "leupeptin", "was", "also", "present", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [16, 17]}}
{"token": ["Immunofluorescence", "microscopy", "cells", "treated", "with", "C0050565#ent", "<e1>", "or", "incubated", "at", "15", "degrees", "C", "has", "suggested", "that", "C3538682#ent", "<e2>", "behaves", "similarly", "to", "proteins", "recycling", "between", "the", "cis-Golgi", "and", "the", "endoplasmic", "reticulum"], "h": {"id": "C0050565", "name": "C0050565#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3538682", "name": "C3538682#ent", "pos": [16, 17]}}
{"token": ["MMF", "activity", "is", "synergistic", "with", "that", "of", "other", "agents", "such", "as", "C0909381#ent", "<e1>", "for", "treating", "C0010823#ent", "<e2>"], "h": {"id": "C0909381", "name": "C0909381#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0010823", "name": "C0010823#ent", "pos": [15, 16]}}
{"token": ["The", "simultaneous", "determination", "of", "seven", "C0031428#ent", "<e1>", ",", "resorcinol", "and", "C0031468#ent", "<e2>", "in", "hair", "coloring", "products", "performed", "by", "liquid", "chromatography", "HPLC", ")", "with", "amperometric", "detection", "(", "ED", ")", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031468", "name": "C0031468#ent", "pos": [10, 11]}}
{"token": ["Despite", "widespread", "use", "of", "C0242708#ent", "<e1>", ",", "we", "observed", "C0012634#ent", "<e2>", "in", "more", "than", "half", "of", "the", "RA", "and", "AS", "patients", "."], "h": {"id": "C0242708", "name": "C0242708#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}}
{"token": ["C0066837#ent", "<e1>", "is", "indicated", "in", "the", "treatment", "of", "essential", "C0020538#ent", "<e2>", "at", "a", "usual", "daily", "dose", "0.4", "mg", "(", "initial", "dose", "of", "0.2", "mg/day", ")", ",", "in", "one", "administration", "per", "day", "."], "h": {"id": "C0066837", "name": "C0066837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}}
{"token": ["We", "also", "expressed", "the", "M-PMV", "mutants", ",", "D26N", "and", "gag-STOP", ",", "which", "carry", "a", "nonfunctional", "C1947941#ent", "<e1>", "or", "fail", "to", "express", "the", "C1335528#ent", "<e2>", "respectively", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335528", "name": "C1335528#ent", "pos": [22, 23]}}
{"token": ["Trefoil", "factor", "family", "2", "C1420701#ent", "<e1>", ")", ",", "also", "known", "as", "C0905072#ent", "<e2>", "is", "a", "member", "of", "the", "trefoil", "family", "peptides", "and", "is", "expressed", "primarily", "in", "the", "mucous", "neck", "cells", "of", "the", "gastric", "mucosa"], "h": {"id": "C1420701", "name": "C1420701#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0905072", "name": "C0905072#ent", "pos": [11, 12]}}
{"token": ["Excessive", "parathyroid", "hormone", "responses", "were", "elicited", "during", "seven", "of", "nine", "EDTA", "infusions", "in", "five", "children", "and", "in", "one", "adult", "with", "C1704375#ent", "<e1>", "during", "the", "active", "phase", "of", "C0035579#ent", "<e2>", "."], "h": {"id": "C1704375", "name": "C1704375#ent", "pos": [20, 21]}, "relation": "has_nichd_parent", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [27, 28]}}
{"token": ["No", "stones", "retrieved", "from", "the", "bile", "duct", "10", "-", "20", "%", "of", "patients", "with", "suspected", "common", "bile", "duct", "C3887938#ent", "<e1>", ")", "stones", "after", "endoscopic", "sphincterotomy", "C1420459#ent", "<e2>", ")", "."], "h": {"id": "C3887938", "name": "C3887938#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420459", "name": "C1420459#ent", "pos": [25, 26]}}
{"token": ["The", "importance", "of", "possible", "C3494359#ent", "<e1>", "symptoms", "suggesting", "a", "C0018824#ent", "<e2>", "stated", ",", "and", "the", "role", "of", "echocardiography", "as", "an", "excellent", "examination", "technique", "discussed", "."], "h": {"id": "C3494359", "name": "C3494359#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [9, 10]}}
{"token": ["To", "analyze", "the", "main", "diagnostic", "problems", "by", "the", "overlap", "between", "Sj\u00f6gren's", "syndrome", "C0085077#ent", "<e1>", ")", "and", "other", "C0751871#ent", "<e2>", "SAD", ")", "."], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0751871", "name": "C0751871#ent", "pos": [17, 18]}}
{"token": ["In", "the", "same", "tissues", ",", "C1705396#ent", "<e1>", "mAbs", "reacted", "with", "the", "thick", "and", "thin", "segments", "medullary", "loops", "C0722058#ent", "<e2>", "(", "Henle's", "loops", "."], "h": {"id": "C1705396", "name": "C1705396#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0722058", "name": "C0722058#ent", "pos": [17, 18]}}
{"token": ["The", "higher", "values", "of", "1/T(2", ")", "in", "the", "C0001614#ent", "<e1>", ",", "putamen", "and", "caudate", "nucleus", "C0005283#ent", "<e2>", "patients", "probably", "reflect", "a", "higher", "iron", "deposition"], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005283", "name": "C0005283#ent", "pos": [15, 16]}}
{"token": ["The", "other", "one", "was", "an", "open-reading-frame", "of", "212", "C3539946#ent", "<e1>", "the", "entire", "C1705722#ent", "<e2>", "cDNA", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705722", "name": "C1705722#ent", "pos": [12, 13]}}
{"token": ["In", "our", "search", "for", "other", "antihemostatic", "factors", "Hirudo", "medicinalis", "saliva", ",", "we", "found", "inhibitors", "of", "platelet", "aggregation", "induced", "by", "C1414504#ent", "<e1>", ",", "collagen", ",", "adenosine", "5'-diphosphate", "epinephrine", ",", "C0914069#ent", "<e2>", "arachidonic", "acid"], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0914069", "name": "C0914069#ent", "pos": [28, 29]}}
{"token": ["Modulation", "of", "C1367475#ent", "<e1>", "and", "CD3", "expression", "similar", "on", "mixed", "splenic", "T", "lymphocytes", "isolated", "CD4", "and", "C1706438#ent", "<e2>"], "h": {"id": "C1367475", "name": "C1367475#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [16, 17]}}
{"token": ["This", "ruled", "out", "a", "direct", "role", "of", "the", "C0754182#ent", "<e1>", "since", "this", "C0001473#ent", "<e2>", "is", "specific", "for", "Mn2", "+", "compared", "to", "Sr2", "+", "."], "h": {"id": "C0754182", "name": "C0754182#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [12, 13]}}
{"token": ["C1418941#ent", "<e1>", "(", "GSS", ")", "disease", "is", "a", "C3538896#ent", "<e2>", "PrP", ")", "amyloidosis", "associated", "with", "mutations", "in", "the", "PrP", "gene", "PRNP", ")", "."], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538896", "name": "C3538896#ent", "pos": [8, 9]}}
{"token": ["A", "chemokine", "receptor", "C1332699#ent", "<e1>", ",", "was", "expressed", "in", "C3539565#ent", "<e2>", "precursors", "and", "elevated", "in", "mature", "OCs", ",", "and", "its", "ligands", "promoted", "C3539565#ent", "<e2>", "precursor", "recruitment", ",", "RANKL", "development", ",", "and", "C3539565#ent", "<e2>", "motility", "."], "h": {"id": "C1332699", "name": "C1332699#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539565", "name": "C3539565#ent", "pos": [9, 10]}}
{"token": ["Here", ",", "we", "characterize", "the", "effects", "of", ",", "a", "novel", "specific", "antagonist", "of", "the", "chemokine", "receptor", "C1332699#ent", "<e1>", ",", "on", "both", "C3539565#ent", "<e2>", "formation", "and", "OC-MM", "cell", "interactions", "."], "h": {"id": "C1332699", "name": "C1332699#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3539565", "name": "C3539565#ent", "pos": [21, 22]}}
{"token": ["Sucrase-isomaltase", "(", "C1420044#ent", "<e1>", ")", "has", "been", "widely", "used", "as", "a", "marker", "C0027203#ent", "<e2>", "to", "study", "cellular", "differentiation", "the", "small", "intestine"], "h": {"id": "C1420044", "name": "C1420044#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["A", "polyclonal", "antiserum", "generated", "against", "the", "purified", "C0027203#ent", "<e1>", "was", "used", "to", "compare", "GTP", "cyclohydrolase", "I", "the", "C3540628#ent", "<e2>", "mutant", "and", "normal", "mouse"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540628", "name": "C3540628#ent", "pos": [17, 18]}}
{"token": ["We", "hypothesized", "that", "ET(A", ")", "blockers", "(", "EMD", "122946", "and", "BQ", "610", ")", "would", "reduce", "hypoxia-induced", "(", "C0813171#ent", "<e1>", ")", "but", "not", "group", "C0038395#ent", "<e2>", "pulmonary", "hypertension", "a", "juvenile", "whole", "animal", "model", "."], "h": {"id": "C0813171", "name": "C0813171#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0038395", "name": "C0038395#ent", "pos": [23, 24]}}
{"token": ["We", "provide", "direct", "evidence", "that", "C1414504#ent", "<e1>", "induces", "a", "rapid", "and", "transient", "activation", "of", "C0812234#ent", "<e2>", "in", "human", "umbilical", "vein", "ECs", "."], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [14, 15]}}
{"token": ["The", "encoded", "protein", "was", "expressed", "as", "a", "fusion", "polypeptide", "C1415329#ent", "<e1>", "and", "the", "affinity-purified", "fusion", "protein", "was", "shown", "to", "possess", "C1615665#ent", "<e2>", "activity", "with", "a", "pH", "optimum", "about", "pH", "4.0", "."], "h": {"id": "C1415329", "name": "C1415329#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1615665", "name": "C1615665#ent", "pos": [20, 21]}}
{"token": ["It", "was", "found", "that", "C1418887#ent", "<e1>", "was", "identified", "as", "Pseudomonas", "fluorescens", "degraded", "C0070570#ent", "<e2>", "better", "than", "strain", "P2", "-", "-Pseudomonas", "cepacia", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0070570", "name": "C0070570#ent", "pos": [12, 13]}}
{"token": ["Phenol", "hydroxylase", "PH", ")", "and", "catechol", "2,3-dioxygenase", "C230", ")", "were", "highly", "induced", "by", "C0070570#ent", "<e1>", "in", "the", "adapted", "strain", "designated", "as", "C1418887#ent", "<e2>", "suggesting", "that", "C0070570#ent", "<e1>", "was", "degraded", "via", "the", "meta-pathway", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0070570", "name": "C0070570#ent", "pos": [13, 14]}}
{"token": ["Our", "controlled", "case", "the", "C1254351#ent", "<e1>", "possibility", "to", "stabilize", "the", "exudative", "form", "of", "C0242383#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [13, 14]}}
{"token": ["We", "have", ",", "therefore", ",", "carried", "out", "a", "study", "using", "colour", "Doppler", "imaging", "evaluate", "a", "C1254351#ent", "<e1>", "capable", "of", "acting", "on", "the", "vascular", "wall", "patients", "with", "C0242383#ent", "<e2>", "diabetic", "retinopathy"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [26, 27]}}
{"token": ["Lead", "poisoning", "an", "important", "environmental", "health", ",", "and", "physicians", "must", "be", "aware", "of", "the", "C0014130#ent", "<e1>", "as", "hyperthyroidism", "and", "C0020502#ent", "<e2>", "that", "increase", "bone", "turnover", "favouring", "lead", "mobilisation", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0020502", "name": "C0020502#ent", "pos": [19, 20]}}
{"token": ["Several", "proteins", "linked", "to", "C0524851#ent", "<e1>", "such", "as", "the", "beta-amyloid", "precursor", "protein", "amyloid", "beta-peptide", "C1569775#ent", "<e2>", ",", "and", "tau", ",", "undergo", "selective", "polarized", "sorting", "."], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1569775", "name": "C1569775#ent", "pos": [14, 15]}}
{"token": ["C0034282#ent", "<e1>", "antagonized", "the", "effects", "of", ",", "C0340861#ent", "<e2>", "and", "H", ",", "and", "partially", "antagonized", "the", "depression", "induced", "by", "4-MH", "."], "h": {"id": "C0034282", "name": "C0034282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0340861", "name": "C0340861#ent", "pos": [7, 8]}}
{"token": ["Iridocyclitis", "has", "been", "identified", "as", "a", "dosage-dependent", "side", "effect", "in", "patients", "with", "the", "C0001175#ent", "<e1>", "AIDS", ")", "who", "are", "treated", "for", "C0026916#ent", "<e2>", "MAC", ")", "infection", "with", "systemic", "rifabutin"], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026916", "name": "C0026916#ent", "pos": [21, 22]}}
{"token": ["Since", "the", "start", "of", "the", "C0001175#ent", "<e1>", "AIDS", ")", "epidemic", ",", "the", "role", "of", "C0026916#ent", "<e2>", "MAC", ")", "as", "an", "opportunistic", "pathogen", "advanced", "AIDS", "patients", "has", "become", "more", "and", "more", "clear", "."], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026916", "name": "C0026916#ent", "pos": [14, 15]}}
{"token": ["Lentiviruses", "such", "as", "C0032306#ent", "<e1>", "MVV", ")", "in", "sheep", ",", "and", "C3854222#ent", "<e2>", "HIV", ")", "in", "man", "often", "cause", "a", "variety", "of", "neurological", "syndromes", "later", "stages", "of", "infection", "."], "h": {"id": "C0032306", "name": "C0032306#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [11, 12]}}
{"token": ["Preliminary", "clinical", "findings", "indicate", "that", "halopemide", "lacks", "the", "ability", "to", "induce", "C0030567#ent", "<e1>", "and", "may", "be", "an", "effective", "C1254351#ent", "<e2>", "in", "the", "treatment", "of", "psychosis", "characterized", "by", "autism", ",", "emotional", "withdrawal", "apathy", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}}
{"token": ["C1333577#ent", "<e1>", "down-regulated", "through", "phosphorylation", "of", "a", "single", "C-terminal", "tyrosine", "the", "C1540033#ent", "<e2>"], "h": {"id": "C1333577", "name": "C1333577#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1540033", "name": "C1540033#ent", "pos": [11, 12]}}
{"token": ["These", "corvid", "specific", "microsatellites", "will", "aid", "ecological", "studies", "of", "the", "population-level", "effects", "of", "C0029896#ent", "<e1>", ",", "such", "as", "C1096184#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1096184", "name": "C1096184#ent", "pos": [18, 19]}}
{"token": ["Pth", "counteracted", "both", "the", "length-dependent", "minigene", "effect", "on", "the", "expression", "of", "beta-galactosidase", "from", "the", "+", "7", "AGA", "C0022959#ent", "<e1>", "reporter", "gene", "the", "positional", "effect", "the", "C0071561#ent", "<e2>", "C0022959#ent", "<e1>", "constructs", "."], "h": {"id": "C0022959", "name": "C0022959#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0071561", "name": "C0071561#ent", "pos": [25, 26]}}
{"token": ["Cotransfection", "of", "C0010531#ent", "<e1>", "expression", "vector", "increased", "the", "ability", "of", "C1415537#ent", "<e2>", "to", "stimulate", "SMemb", "promoter", "activity", "in", "a", "CRE-dependent", "manner", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415537", "name": "C1415537#ent", "pos": [10, 11]}}
{"token": ["Tested", "whether", "metabolic", "control", "treatment", "variables", "and", "psychosocial", "factors", "associated", "with", "onset", "of", "C0030920#ent", "<e1>", "PUD", ")", "in", "14", "Ss", "with", "C3273872#ent", "<e2>", "who", "later", "developed", "PUD", "and", "a", "matched", "group", "14", "Ss", "who", "did", "not", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [21, 22]}}
{"token": ["The", "UV5", "mutant", "line", "was", "also", "applied", "to", "problems", "in", "environmental", "mutagenesis", "introducing", "the", "mouse", "cytochrome", "P(3)450", "(", "P450IA2", "subfamily", ")", "C0017337#ent", "<e1>", "for", "metabolic", "activation", "of", "C0772162#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0772162", "name": "C0772162#ent", "pos": [27, 28]}}
{"token": ["A", "significant", "reduction", "of", "exercise-induced", "ischaemia", "normotensive", "patients", "with", "C0010068#ent", "<e1>", "was", "not", "demonstrated", "with", "C0057301#ent", "<e2>", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0057301", "name": "C0057301#ent", "pos": [15, 16]}}
{"token": ["If", "C1418994#ent", "<e1>", "is", "considered", "together", "with", "C0376147#ent", "<e2>", ",", "a", "discriminant", "function", "be", "calculated", ",", "separating", "patients", "with", "acute", "liver", "damage", "those", "with", "an", "acute", "exacerbation", "chronic", "active", "hepatitis", "with", "a", "high", "degree", "of", "certainty", "."], "h": {"id": "C1418994", "name": "C1418994#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0376147", "name": "C0376147#ent", "pos": [7, 8]}}
{"token": ["33", "patients", "had", "Graves", "disease", "5", "periodic", "paralysis", "4", "C0677607#ent", "<e1>", "and", "4", "epilepsy", ",", "polymyositis", ",", "rheumatoid", "arthritis", "C3825808#ent", "<e2>", "."], "h": {"id": "C0677607", "name": "C0677607#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3825808", "name": "C3825808#ent", "pos": [19, 20]}}
{"token": ["Basophilic", "and", "chromophobic", "tumors", "from", "specific", "segments", "of", "the", "proximal", "tubules", ",", "characteristic", "for", "each", "carcinogen", ":", "C1419693#ent", "<e1>", ",", "P3C", "and", "P3", "M", "for", "C0000975#ent", "<e2>", "C1419693#ent", "<e1>", "and", "P3C", "for", "N-nitrosodiethylamine", "."], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [25, 26]}}
{"token": ["Pretreatment", "of", "the", "C3850100#ent", "<e1>", "carbidopa", "suppressed", "5-HTP-induced", "C0268576#ent", "<e2>", "."], "h": {"id": "C3850100", "name": "C3850100#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268576", "name": "C0268576#ent", "pos": [8, 9]}}
{"token": ["However", ",", "both", "transcription", "and", "replication", "activities", "only", "the", "80-amino-acid", "fragment", "of", "MCM1", "C1334043#ent", "<e1>", "to", "the", "DNA-binding", "domain", "the", "C1420400#ent", "<e2>", "SRF", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420400", "name": "C1420400#ent", "pos": [20, 21]}}
{"token": ["Molecular", "cloning", "identified", "C1417679#ent", "<e1>", "encoding", "spliceosomal", "proteins", "potentially", "act", "as", "novel", "RNA", "helicases", "C0242853#ent", "<e2>", ",", "or", "protein", "isomerases"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [14, 15]}}
{"token": ["However", ",", "over", "half", "the", "patients", "reported", "C0000737#ent", "<e1>", "a", "quarter", "reported", "flatulence", ",", "and", "a", "quarter", "C0013395#ent", "<e2>", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [17, 18]}}
{"token": ["Counteracting", "the", "promodulatory", "actions", "of", "HDL", "and", "estrogen", ",", "C-reactive", "protein", "C1826658#ent", "<e1>", ")", "antagonizes", "eNOS", "through", "FcgammaRIIB", "and", "C1704708#ent", "<e2>", ",", "which", "dephosphorylates", "and", "inactivates", "the", "enzyme", "."], "h": {"id": "C1826658", "name": "C1826658#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [19, 20]}}
{"token": ["The", "pharmacokinetics", "of", "lamotrigine", "(", "C1420817#ent", "<e1>", ")", "and", "effects", "of", "carbamazepine", "(", "CBZ", ")", ",", "valproic", "acid", "VPA", ")", "and", "C0078844#ent", "<e2>", "(", "ZNS", ")", "on", "C1420817#ent", "<e1>", "kinetics", "were", "investigated", "in", "rats", "."], "h": {"id": "C0078844", "name": "C0078844#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420817", "name": "C1420817#ent", "pos": [5, 6]}}
{"token": ["Moreover", ",", "Ren-2", "expression", "in", "the", "C1826968#ent", "<e1>", "was", "positively", "regulated", "by", "C0002842#ent", "<e2>", "."], "h": {"id": "C1826968", "name": "C1826968#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [12, 13]}}
{"token": ["Taken", "together", ",", "these", "data", "suggest", "that", "C1826968#ent", "<e1>", "renin", "is", "influenced", "by", "C0002842#ent", "<e2>", ",", "whereas", "renal", "renin", "not", "."], "h": {"id": "C1826968", "name": "C1826968#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [13, 14]}}
{"token": ["Cholesterol", "sulfate", "no", "effect", "C0028928#ent", "<e1>", "incorporation", "into", "C0012262#ent", "<e2>", ",", "triglycerides", ",", "or", "phospholipid", "fractions", "neither", "did", "it", "inhibit", "acid", "lipase", ";", "nor", "did", "it", "inhibit", "fatty", "acid", "oxidation", "indicating", "that", "cholesterol", "sulfate", "not", "inhibit", "catabolism", "of", "acyl", "lipids"], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012262", "name": "C0012262#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", "to", "wild-type", "C1413800#ent", "<e1>", ",", "the", "microtubule-associated", "C1413800#ent", "<e1>", "mutant", "did", "not", "activate", "C1419227#ent", "<e1>", "and", "did", "not", "induce", "a", "dendritic", "morphology", "."], "h": {"id": "C1413800", "name": "C1413800#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419227", "name": "C1419227#ent", "pos": [15, 16]}}
{"token": ["Blocking", "of", "C3273872#ent", "<e1>", "sera", "with", "recombinant", "IA-2", "IA-2", "beta", ",", "or", "C1414926#ent", "<e2>", "resulted", "in", "marked", "inhibition", "of", "reactivity", "of", "C3273872#ent", "<e1>", "sera", "with", "pancreatic", "islet", "as", "measured", "by", "islet", "cell", "autoantibody", "immunofluorescence", "."], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414926", "name": "C1414926#ent", "pos": [12, 13]}}
{"token": ["Reducing", "C0991617#ent", "<e1>", "enhanced", "the", "production", "of", "the", "functional", "C1504769#ent", "<e2>", "in", "an", "in", "vitro", "translation", "system"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [9, 10]}}
{"token": ["Avp", ",", "oxytocin", "(", "Oxt", ")", "and", "Crh", "mRNA", "expression", "in", "the", "PVN", "did", "not", "change", "in", "fluoxetine-treated", "male", "C1332123#ent", "<e1>", "KO", "or", "C2987364#ent", "<e2>"], "h": {"id": "C1332123", "name": "C1332123#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [23, 24]}}
{"token": ["Conversely", ",", "the", "ACTH", "response", "to", "the", "acute", "stressors", "significantly", "attenuated", "in", "C1332123#ent", "<e1>", "knockout", "mice", "to", "their", "C2987364#ent", "<e2>", "counterparts", "."], "h": {"id": "C1332123", "name": "C1332123#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [18, 19]}}
{"token": ["Both", "groups", "of", "dependent", "dogs", "had", "clonic", "and", "C0014549#ent", "<e1>", "oral", "and", "C0016293#ent", "<e2>"], "h": {"id": "C0014549", "name": "C0014549#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016293", "name": "C0016293#ent", "pos": [12, 13]}}
{"token": ["Direct", "immunofluorescence", "studies", "demonstrated", "C1706005#ent", "<e1>", "and", "C3", "of", "the", "vessel", "walls", "suggesting", "C0020951#ent", "<e2>", "deposition", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [13, 14]}}
{"token": ["Complete", "muscular", "paralysis", "induced", "with", "C0016972#ent", "<e1>", "an", "increase", "in", "the", "C2926735#ent", "<e2>", "of", "inspiration", "and", "an", "increase", "in", "the", "amplitude", "of", "the", "integrated", "phrenic", "electroneurogram", "."], "h": {"id": "C0016972", "name": "C0016972#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [11, 12]}}
{"token": ["The", "genetic", "polymorphisms", "aldehyde", "dehydrogenase-2", "ALDH2", ")", ",", "alcohol", "dehydrogenase-2", "ADH2", ")", ",", "C3811648#ent", "<e1>", ",", "and", "glutathione", "S-transferase", "M1", "GSTM1", ")", "influence", "the", "metabolism", "of", "C0001962#ent", "<e2>", "and", "other", "carcinogens", "."], "h": {"id": "C3811648", "name": "C3811648#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [26, 27]}}
{"token": ["Two", "of", "the", "three", "class", "I", "alcohol", "dehydrogenase", "ADH", ")", "genes", "(", "ADH2", "and", "C3811648#ent", "<e1>", ")", "encode", "known", "functional", "variants", "that", "act", "on", "C0001962#ent", "<e2>", "with", "different", "efficiencies", "."], "h": {"id": "C3811648", "name": "C3811648#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [24, 25]}}
{"token": ["It", "has", "also", "been", "possible", "to", "demonstrate", "a", "good", "correlation", "between", "the", "levels", "of", "circulating", "C0403529#ent", "<e1>", "the", "clinical", "course", "disease", "in", "one", "patient", "with", "C0403529#ent", "<e1>"], "h": {"id": "C0403529", "name": "C0403529#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0403529", "name": "C0403529#ent", "pos": [15, 16]}}
{"token": ["Production", "of", "C0961802#ent", "<e1>", "is", "highest", "at", "low", "concentrations", "of", "ancrod", ",", "whereas", "C0961802#ent", "<e1>", "is", "rapidly", "converted", "to", "C0642775#ent", "<e1>", "at", "higher", "concentrations", "of", "ancrod", "."], "h": {"id": "C0961802", "name": "C0961802#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0642775", "name": "C0642775#ent", "pos": [19, 20]}}
{"token": ["An", "C0027203#ent", "<e1>", "which", "reduces", "glycolate", "to", "C0063555#ent", "<e2>", "as", "the", "first", "step", "of", "the", "biosynthesis", "of", "vitamin", "B6", "studied", "using", "the", "particulate", "fraction", "of", "Flavobacterium", "sp.", "-", "7", ",", "a", "vitamin", "B6", "producer"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0063555", "name": "C0063555#ent", "pos": [7, 8]}}
{"token": ["Basal", "cell", "carcinoma", "medulloblastoma", ",", "rhabdomyosarcoma", "and", "other", "human", "tumours", "are", "associated", "with", "mutations", "that", "activate", "the", "C0033713#ent", "<e1>", "SMO", ")", "or", "that", "inactivate", "the", "tumour", "suppressor", "Patched", "C1705339#ent", "<e2>", ")", "."], "h": {"id": "C0033713", "name": "C0033713#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705339", "name": "C1705339#ent", "pos": [28, 29]}}
{"token": ["The", "most", "common", "C0040128#ent", "<e1>", "was", "autoimmune", "thyroiditis", "the", "most", "common", "hormonal", "pattern", "C0271790#ent", "<e2>"], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0271790", "name": "C0271790#ent", "pos": [13, 14]}}
{"token": ["The", "gene", "associated", "with", "loss", "of", "growth", "promotion", "H41", "was", "shown", "to", "exhibit", "65", "%", "identity", "at", "the", "C2917660#ent", "<e1>", "level", "to", "the", "nadC", "gene", "encoding", "quinolinate", "phosphoribosyltransferase", "C1531278#ent", "<e2>", ")", "in", "Ralstonia", "solanacearum"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1531278", "name": "C1531278#ent", "pos": [28, 29]}}
{"token": ["The", "C0003297#ent", "<e1>", "used", "were", "scopolamine", "HBr", ",", "cyclizine", ",", "prochlorperazine", "dimaleate", "and", "C0077163#ent", "<e2>", "."], "h": {"id": "C0003297", "name": "C0003297#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0077163", "name": "C0077163#ent", "pos": [13, 14]}}
{"token": ["In", "cortical", "slices", ",", "low", "C0008783#ent", "<e1>", "concentrations", "facilitated", "C0002403#ent", "<e2>", "accumulation", ",", "whereas", "higher", "concentrations", "produced", "inhibition", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002403", "name": "C0002403#ent", "pos": [9, 10]}}
{"token": ["Three", "patients", ",", "initially", "diagnosed", "with", "C0009088#ent", "<e1>", "were", "subsequently", "found", "to", "have", "C0154945#ent", "<e2>"], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0154945", "name": "C0154945#ent", "pos": [13, 14]}}
{"token": ["Multivariate", "analysis", "that", "C0013595#ent", "<e1>", "and", "dry", "cough", "independently", "associated", "with", "LTE4", "excretion", "during", "C0006274#ent", "<e2>", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006274", "name": "C0006274#ent", "pos": [14, 15]}}
{"token": ["These", "have", "led", "to", "the", "use", "of", "C1522405#ent", "<e1>", "(", "IL-2", ")", "in", "a", "guinea", "pig", "model", "of", "C1318711#ent", "<e2>", "genital", "infection"], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1318711", "name": "C1318711#ent", "pos": [18, 19]}}
{"token": ["Neither", "overexpression", "of", "TGFbetaRII", "in", "RIE-Ras", "cells", "nor", "expression", "of", "C0907533#ent", "<e1>", "active", "TGFbetaRI", "restored", "sensitivity", "to", "C1366557#ent", "<e2>", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366557", "name": "C1366557#ent", "pos": [17, 18]}}
{"token": ["The", "relationships", "between", "glucose", "metabolism", "C0032594#ent", "<e1>", "(", "EPS", ")", "production", "in", "a", "Lactococcus", "lactis", "strain", "the", "C1413514#ent", "<e2>", "Eps(+", ")", ")", "and", "in", "nonproducer", "strain", "MG5267", "(", "Eps(-", ")", ")", "were", "characterized", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413514", "name": "C1413514#ent", "pos": [17, 18]}}
{"token": ["Mutations", "in", "the", "GHR", "cause", "severe", "postnatal", "C0878787#ent", "<e1>", "the", "disorder", "is", "an", "autosomal", "recessive", "C0037277#ent", "<e2>", "in", "GH", "insensitivity", ",", "called", "Laron", "syndrome"], "h": {"id": "C0878787", "name": "C0878787#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [15, 16]}}
{"token": ["Since", "C1332075#ent", "<e1>", "is", "the", "ligand", "for", "C1413232#ent", "<e2>", ",", "a", "member", "of", "the", "immunological", "synapse", "T", "cells", "its", "removal", "by", "viral", "immune", "modulators", "a", "role", "for", "C1413232#ent", "<e2>", "in", "the", "recognition", "of", "pathogens", "by", "T", "cells"], "h": {"id": "C1332075", "name": "C1332075#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413232", "name": "C1413232#ent", "pos": [7, 8]}}
{"token": ["Virological", "investigations", "that", "virologically", "unclarified", "(", "and", ",", "hence", ",", "vaccine-induced", ")", "C0236811#ent", "<e1>", "not", "occur", "more", "frequently", "in", "C1420610#ent", "<e2>", "vaccines", "than", "in", "unvaccinated", "persons.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0236811", "name": "C0236811#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420610", "name": "C1420610#ent", "pos": [19, 20]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "investigate", "whether", "C0018681#ent", "<e1>", "in", "women", "with", "nonpuerperal", "hyperprolactinemia", "related", "to", "elevated", "serum", "prolactin", "C3273356#ent", "<e2>", ")", "levels", "or", "the", "presence", "of", "a", "PRL-secreting", "pituitary", "adenoma"], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273356", "name": "C3273356#ent", "pos": [20, 21]}}
{"token": ["T", "injection", "was", "followed", "by", "severe", "C0018681#ent", "<e1>", ",", "facial", "pain", "and", "increase", "in", "C3273356#ent", "<e2>", "to", "13,471", "ng/ml", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273356", "name": "C3273356#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "IncI1", "plasmids", "were", "identified", "in", "E.", "coli", "C0036117#ent", "<e1>", "animal", "origin", "responsible", "for", "the", "dissemination", "of", "C0597979#ent", "<e2>"], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0597979", "name": "C0597979#ent", "pos": [18, 19]}}
{"token": ["A", "comprehensive", ",", "practical", "review", "of", "the", "short-", "and", "long-term", "therapy", "for", "patients", "with", "diabetes", "insipidus", "including", "C0687720#ent", "<e1>", "nephrogenic", "diabetes", "insipidus", "and", "the", "\"", "excessive", "C0687720#ent", "<e1>", "\"", "is", "presented", "."], "h": {"id": "C0687720", "name": "C0687720#ent", "pos": [17, 18]}, "relation": "manifestation_of", "t": {"id": "C0687720", "name": "C0687720#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "indicate", "that", "stress-induced", "phosphorylation", "of", "C3539639#ent", "<e1>", "directly", "coupled", "to", "mitochondrial", "apoptosis", "regulation", "via", "translational", "repression", "C1366587#ent", "<e2>", "."], "h": {"id": "C3539639", "name": "C3539639#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366587", "name": "C1366587#ent", "pos": [18, 19]}}
{"token": ["Oxycodone/ibuprofen", "5", "mg/400", "mg", "(", "C1618777#ent", "<e1>", ")", "is", "an", "oral", "fixed-dose", "combination", "tablet", "with", "C0728960#ent", "<e2>", ",", "anti-inflammatory", "and", "antipyretic", "properties", "."], "h": {"id": "C1618777", "name": "C1618777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [15, 16]}}
{"token": ["C0029408#ent", "<e1>", "caused", "by", "M.", "bovis", "was", "observed", "in", "12", "C1519228#ent", "<e2>", "until", "July", "1991", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1519228", "name": "C1519228#ent", "pos": [10, 11]}}
{"token": ["human", "papillomavirus", "type16", "E6", "expression", "promoted", "additional", "growth", "of", "up", "to", "12", "pd", ",", "until", "a", "second", "telomere-independent", "C1428925#ent", "<e1>", "(", "termed", "M(INT", ")", ")", "was", "imposed", "associated", "with", "elevated", "C0525037#ent", "<e2>", "."], "h": {"id": "C1428925", "name": "C1428925#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [30, 31]}}
{"token": ["In", "this", "review", ",", "we", "discuss", "evidence", "derived", "from", "in", "vitro", "experiments", ",", "suggesting", "that", "the", "stimulation", "of", "protein", "kinase", "C", "M1/M3", "C1332758#ent", "<e1>", "increases", "the", "nonamyloidogenic", ",", "secretory", "pathway", "C1364818#ent", "<e2>", "processing", "."], "h": {"id": "C1332758", "name": "C1332758#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [30, 31]}}
{"token": ["We", "propose", "that", "GATA", "and", "C2346452#ent", "<e1>", "fine-tune", "accessibility", "at", "the", "C1334119#ent", "<e2>", "locus", "during", "development", "to", "variably", "regulate", "IL-4", "expression", "."], "h": {"id": "C2346452", "name": "C2346452#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334119", "name": "C1334119#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "suggest", "that", "C0086132#ent", "<e1>", "have", "a", "greater", "impact", "on", "quality", "of", "life", "C0019099#ent", "<e2>", "patients", "than", "severity", "of", "cardiac", "dysfunction", "functional", "impairment"], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [14, 15]}}
{"token": ["PCR", "amplification", "of", "genomic", "C0011519#ent", "<e1>", "of", "both", "cholera", "toxin", "gene", "C3539598#ent", "<e2>", ")", "positive", "and", "ctx-", "strains", "of", "V.", "mimicus", "detected", "the", "presence", "of", "zot", "gene", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539598", "name": "C3539598#ent", "pos": [11, 12]}}
{"token": ["C0010557#ent", "<e1>", "is", "an", "C0001640#ent", "<e2>", "effectively", "depletes", "the", "serous", "cells", "their", "granules", "and", "their", "heavy", "metal", "content", "."], "h": {"id": "C0010557", "name": "C0010557#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [4, 5]}}
{"token": ["The", "phosphoinositide", "3-kinases", "C0044602#ent", "<e1>", ")", "are", "a", "family", "of", "C0031727#ent", "<e2>", "have", "a", "key", "role", "in", "the", "regulation", "of", "many", "cellular", "processes", "proliferation", ",", "survival", ",", "carbohydrate", "metabolism", "and", "motility", "."], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [10, 11]}}
{"token": ["Although", "the", "C0162429#ent", "<e1>", "control", "group", "a", "high", "C1707081#ent", "<e2>", ",", "underfeeding", "had", "no", "effect", "the", "C1707081#ent", "<e2>", "of", "groups", "with", "IUGR", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1707081", "name": "C1707081#ent", "pos": [8, 9]}}
{"token": ["Thus", ",", "the", "local", "secondary", "structure", "C2917660#ent", "<e1>", "rather", "than", "a", "particular", "C2917660#ent", "<e1>", "se", "is", "involved", "in", "C0008272#ent", "<e1>", "induction", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008272", "name": "C0008272#ent", "pos": [18, 19]}}
{"token": ["SKF", "38393", "and", "(-)-quinpirole", ",", "however", ",", "exhibited", "no", "effect", "on", "striatal", "synaptosomal", "AADC", "activity", ",", "suggesting", "that", "only", "the", "mixed", "C0178601#ent", "<e1>", "reduce", "the", "C4283880#ent", "<e2>", "activity", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C4283880", "name": "C4283880#ent", "pos": [25, 26]}}
{"token": ["The", "IC50", "for", "PTX", "(", "7", "ng/ml", ")", "was", "similar", "to", "that", "for", "blocking", "of", "C0178469#ent", "<e1>", "decreases", "in", "cyclic", "C1706611#ent", "<e2>", "accumulation", "in", "the", "same", "cells", "."], "h": {"id": "C0178469", "name": "C0178469#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1706611", "name": "C1706611#ent", "pos": [20, 21]}}
{"token": ["This", "experience", "demonstrates", "the", "favorable", "alternative", "of", "prazosin", "nitroprusside-like", "actions", "over", "hydralazine-nitrate", "therapy", "in", "C0018801#ent", "<e1>", "emphasizes", "prazosin's", "when", "untoward", "side", "effects", "C0020223#ent", "<e2>", "develop", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0020223", "name": "C0020223#ent", "pos": [22, 23]}}
{"token": ["A", "7", "year", "old", "girl", "referred", "for", "investigation", "of", "C2936664#ent", "<e1>", "had", "hypoalbuminaemia", "and", "severe", "C0341110#ent", "<e2>", "oesophagogastroduodenoscopy", "."], "h": {"id": "C2936664", "name": "C2936664#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0341110", "name": "C0341110#ent", "pos": [15, 16]}}
{"token": ["We", "present", "an", "extremely", "rare", "case", "of", "C0024291#ent", "<e1>", "HPS", ")", "induced", "by", "C0032302#ent", "<e2>", "Mp", ")", "pneumonia", "in", "an", "elderly", "adult"], "h": {"id": "C0024291", "name": "C0024291#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032302", "name": "C0032302#ent", "pos": [13, 14]}}
{"token": ["We", "report", "3", "cases", "of", "AIDS", "complicated", "by", "C0026848#ent", "<e1>", "2", "with", "acute", "polymyositis", "1", "with", "severe", "C0027121#ent", "<e2>"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0027121", "name": "C0027121#ent", "pos": [17, 18]}}
{"token": ["The", "effects", "of", "damage", "were", "assessed", "in", "rat", "proximal", "tubule", "fragments", "isolated", "by", "C0162745#ent", "<e1>", "by", "monitoring", "lactate", "dehydrogenase", "(", "LDH-R", ")", "to", "measure", "cell", "viability", "C0039925#ent", "<e2>", "TBA", ")", "reactive", "material", "follow", "oxidative", "damage", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [26, 27]}}
{"token": ["To", "assess", "the", "effect", "of", "the", "duration", "of", "C0567085#ent", "<e1>", "preparation", "with", "E2", "on", "pregnancy", "rates", "C1839730#ent", "<e2>", ")", "in", "oocyte", "donation", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1839730", "name": "C1839730#ent", "pos": [16, 17]}}
{"token": ["Recombinant", "human", "C1414929#ent", "<e1>", "and", "its", "C0036584#ent", "<e2>", "expressed", "in", "an", "Escherichia", "coli", "expression", "system", "purified", ";", "they", "were", "then", "crystallized", "using", "the", "hanging-drop", "vapour-diffusion", "method", "."], "h": {"id": "C1414929", "name": "C1414929#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036584", "name": "C0036584#ent", "pos": [6, 7]}}
{"token": ["Time-of-flight", "data", "captured", "by", "a", "dedicated", "acquisition", "system", "pre-processes", "the", "information", "using", "a", "C1414174#ent", "<e1>", "and", "transfers", "the", "results", "to", "a", "C3811118#ent", "<e2>", "via", "a", "fast", "serial", "link", "."], "h": {"id": "C1414174", "name": "C1414174#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [21, 22]}}
{"token": ["The", "higher", "median", "age", "education", "less", "primary", "school", "level", "longer", "C0720099#ent", "<e1>", "of", "occupation", ",", "longer", "C0720099#ent", "<e1>", "of", "each", "C4085339#ent", "<e1>", "and", "a", "previous", "history", "of", "genital", "ulcer", "disease", "significant", "risk", "factors", "the", "acquisition", "of", "HIV", "infection"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4085339", "name": "C4085339#ent", "pos": [20, 21]}}
{"token": ["C1539887#ent", "<e1>", "and", "BRA1", "are", "new", "genes", "encoding", ",", "respectively", ",", "C0020687#ent", "<e2>", "adenylosuccinate", "lyase"], "h": {"id": "C1539887", "name": "C1539887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020687", "name": "C0020687#ent", "pos": [11, 12]}}
{"token": ["In", "such", "a", "case", ",", "angiotensin", "converting", "C0027203#ent", "<e1>", "inhibition", "with", "ramipril", "should", "prevent", "natriuresis", "with", "C0015772#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [16, 17]}}
{"token": ["Activation", "of", "CFTR", "channels", "was", "obtained", "with", "3-mono", ",", "1,3-di", "or", "1,3,7-tri-substituted", "alkyl", "xanthine", "derivatives", "(", "C0059372#ent", "<e1>", ",", "theophylline", ",", "aminophylline", ",", "C0000096#ent", "<e2>", ",", "DPMX", "and", "pentoxifylline", ")", "."], "h": {"id": "C0059372", "name": "C0059372#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0000096", "name": "C0000096#ent", "pos": [23, 24]}}
{"token": ["Pre-incubation", "of", "rat", "aortic", "VSMCs", "with", "luteolin", "significantly", "inhibited", "the", "PDGF-BB-induced", "extracellular", "signal-regulated", "kinase", "1/2", "(", "ERK1/2", ")", ",", "C0812228#ent", "<e1>", "and", "phospholipase", "C", "activation", "as", "well", "as", "C0085940#ent", "<e2>", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0085940", "name": "C0085940#ent", "pos": [28, 29]}}
{"token": ["Changes", "in", "cellular", "C1705556#ent", "<e1>", "concentrations", "(", "[", "C1705556#ent", "<e1>", "]", ")", "and", "C0031306#ent", "<e1>", "acute", "hypoxia", "be", "important", "in", "conditions", "associated", "with", "low", "alveolar", "O2"], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031306", "name": "C0031306#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "joint", "activation", "5-HT1A", "and", "5-HT1B", "receptors", "stimulates", "locomotion", "in", "WT", "mice", "this", "response", "is", "dependent", "on", "a", "functional", "C1415811#ent", "<e1>", "and", "hence", "is", "absent", "in", "C1415811#ent", "<e1>", "KO", "mice", "."], "h": {"id": "C1415811", "name": "C1415811#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1415811", "name": "C1415811#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "the", "possible", "association", "between", "the", "C0919451#ent", "<e1>", "genotype", "and", "allelic", "variants", "and", "the", "risk", "for", "C1414474#ent", "<e2>", "ET", ")", "."], "h": {"id": "C0919451", "name": "C0919451#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414474", "name": "C1414474#ent", "pos": [17, 18]}}
{"token": ["Physical", "interaction", "C1335654#ent", "<e1>", "with", "C1335193#ent", "<e2>", "correlates", "with", "functional", "cooperativity", "in", "transfection", "studies", "C1335654#ent", "<e1>", "and", "C1335193#ent", "<e2>", "synergistically", "activate", "blk", "promoter", "transcription", "by", "more", "than", "50-fold", "."], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [2, 3]}}
{"token": ["These", "results", "demonstrate", "physical", "and", "functional", "interactions", "between", "C1335654#ent", "<e1>", "and", "C1335193#ent", "<e2>", "and", "suggest", "that", "C1335654#ent", "<e1>", "is", "an", "important", "factor", "for", "regulating", "a", "critical", "B", "cell-specific", "gene", "blk", "."], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [8, 9]}}
{"token": ["Patients", "were", "then", "classified", "as", "CR+", "or", "CR-", "based", "on", "number", "of", "improved", "segments", "(", "IC", "group", ")", "or", "ejection", "fraction", "improvement", "C1449563#ent", "<e1>", "group", ")", "in", "response", "to", "C0700450#ent", "<e2>", "."], "h": {"id": "C1449563", "name": "C1449563#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0700450", "name": "C0700450#ent", "pos": [29, 30]}}
{"token": ["Mastitis", ",", "metritis", ",", "C0023895#ent", "<e1>", "nutritional", "imbalances", ",", "C0178829#ent", "<e2>", "stress", ",", "specific", "diseases", "and", "non-specific", "inflammations", "reviewed", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0178829", "name": "C0178829#ent", "pos": [9, 10]}}
{"token": ["This", "study", "evaluated", "the", "effects", "of", "C0082607#ent", "<e1>", "%", "on", "the", "hypothalamopituitary-adrenal", "(HPA)", "axis", "patients", "with", "extensive", "C0033860#ent", "<e2>", "or", "eczema", "."], "h": {"id": "C0082607", "name": "C0082607#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "the", "possibility", "of", "differential", "diagnosis", "of", "C0268242#ent", "<e1>", "by", "detecting", "C0022173#ent", "<e2>", "by", "this", "method", "was", "examined", "after", "isoelectric", "focusing", "of", "placental", "sphingomyelinase", "."], "h": {"id": "C0268242", "name": "C0268242#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [12, 13]}}
{"token": ["Organic", "anions", "penicillin", "G", "p-aminohippurate", ",", "salicylate", ",", "and", "C0033209#ent", "<e1>", "significantly", "inhibited", "C0042291#ent", "<e2>", "uptake", "by", "choroid", "plexus"], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [13, 14]}}
{"token": ["Some", "authors", "have", "suggested", "that", "C1413682#ent", "<e1>", "is", "more", "important", "in", "influencing", "outcome", "than", "is", "C0033845#ent", "<e2>", "a", "hypothesis", "that", "this", "study", "was", "designed", "to", "investigate", "."], "h": {"id": "C1413682", "name": "C1413682#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033845", "name": "C0033845#ent", "pos": [15, 16]}}
{"token": ["C1861185#ent", "<e1>", "detected", "in", "a", "horse", "with", "equine", "C0014661#ent", "<e2>", "EIA", ")", "."], "h": {"id": "C1861185", "name": "C1861185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014661", "name": "C0014661#ent", "pos": [8, 9]}}
{"token": ["Taken", "together", ",", "these", "results", "provide", "evidence", "for", "a", "cross-talk", "mechanism", "C3899164#ent", "<e1>", "and", "TCF", "signaling", "in", "which", "C1332803#ent", "<e2>", "plays", "a", "central", "regulatory", "role"], "h": {"id": "C3899164", "name": "C3899164#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "persons", "taking", "C0132326#ent", "<e1>", "PEP", "after", "C0019693#ent", "<e2>", "exposure", "also", "are", "at", "risk", "for", "serious", "and", "adverse", "events"], "h": {"id": "C0132326", "name": "C0132326#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [8, 9]}}
{"token": ["However", ",", "many", "issues", ",", "even", "those", "as", "basic", "as", "whether", "C1415692#ent", "<e1>", "induces", "or", "protects", "against", "C0017168#ent", "<e2>", ",", "are", "still", "controversial", "."], "h": {"id": "C1415692", "name": "C1415692#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [17, 18]}}
{"token": ["Whereas", ",", "exogenous", "supply", "of", "propargylglycine", "(", "C1418888#ent", "<e1>", ")", ",", "an", "inhibitor", "of", "C0010642#ent", "<e2>", "CSE", ")", ",", "decreased", "the", "plasma", "H2S", "content", "and", "worsened", "HPH", "."], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010642", "name": "C0010642#ent", "pos": [14, 15]}}
{"token": ["However", ",", "injection", "of", "C1418888#ent", "<e1>", ",", "an", "inhibitor", "of", "C0010642#ent", "<e2>", ",", "decreased", "the", "zinc-induced", "MT", "synthesis", "in", "the", "tumors", "and", "also", "decreased", "the", "tumor", "weight", "exposure", "to", "X", "radiation"], "h": {"id": "C1418888", "name": "C1418888#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010642", "name": "C0010642#ent", "pos": [10, 11]}}
{"token": ["Enhanced", "DA", "output", ",", "however", ",", "was", "declined", "slightly", "by", "epicatechine", "and", "C0007404#ent", "<e1>", ",", "and", "not", "altered", "significantly", "by", "C0282908#ent", "<e2>", "quercetin", "dehydrate", "which", "are", "other", "penolic", "compounds", "in", "the", "red", "wine"], "h": {"id": "C0007404", "name": "C0007404#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282908", "name": "C0282908#ent", "pos": [20, 21]}}
{"token": ["Mutations", "in", "12", "different", "PEX", "C0017337#ent", "<e1>", "can", "cause", "a", "C1856186#ent", "<e2>", "clinical", "phenotypes", "ranging", "from", "Zellweger", "syndrome", "infantile", "Refsum", "disease"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1856186", "name": "C1856186#ent", "pos": [10, 11]}}
{"token": ["The", "stalked", "cell", "which", "initiates", "chromosome", "replication", "upon", "division", ",", "received", "the", "C1334043#ent", "<e1>", "the", "DnaK", "homolog", "and", "the", "37,000", "C1335628#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335628", "name": "C1335628#ent", "pos": [20, 21]}}
{"token": ["Intravenous", "antiplatelet", "agents", "such", "as", "abciximab", ",", "C0795668#ent", "<e1>", ",", "and", "eptifibitide", "were", "also", "proven", "effective", "in", "acute", "coronary", "syndromes", "C0002965#ent", "<e2>"], "h": {"id": "C0795668", "name": "C0795668#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [20, 21]}}
{"token": ["Two", "hormone-responsive", "segments", "one", "in", "the", "region", "of", "the", "promoter", "and", "one", "in", "intron", "1", "are", "identified", "in", "two", "homologous", "androgen-regulated", "and", "differentially", "expressed", "rat", "C1417679#ent", "<e1>", "encoding", "the", "cystatin-related", "proteins", "C0458219#ent", "<e2>", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0458219", "name": "C0458219#ent", "pos": [31, 32]}}
{"token": ["The", "lower", "C1417807#ent", "<e1>", "concentration", "in", "the", "C1868117#ent", "<e2>", "group", "in", "the", "luteal", "phases", "indicate", "either", "a", "lower", "plasma", "volume", "or", "a", "decrease", "in", "the", "total", "body", "sodium", "content", "or", "both", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1868117", "name": "C1868117#ent", "pos": [7, 8]}}
{"token": ["Unintentional", "contamination", "artificial", "tear", "products", "potentiates", "a", "risk", "of", "developing", "C0022568#ent", "<e1>", "exacerbating", "an", "existing", "C0015403#ent", "<e2>"], "h": {"id": "C0022568", "name": "C0022568#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0015403", "name": "C0015403#ent", "pos": [15, 16]}}
{"token": ["C0013227#ent", "<e1>", "induced", "regulation", "of", "MMP-1", ",", "other", "C3494976#ent", "<e2>", "and", "TIMPs", "is", "critical", "in", "treatment", "of", "various", "diseases", ",", "e.g.", "the", "use", "of", "the", "plant", "alkaloid", "colchicine", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3494976", "name": "C3494976#ent", "pos": [8, 9]}}
{"token": ["Sequence", "analyses", "that", "clone", "1", "was", "similar", "to", "a", "C0078147#ent", "<e1>", "87", "%", "at", "the", "nucleotide", "level", "80", "%", "at", "the", "C2917660#ent", "<e2>", "level", ")", "and", "clone", "2", "identical", "to", "a", "region", "of", "the", "Huntington", "disease", "protein"], "h": {"id": "C0078147", "name": "C0078147#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [21, 22]}}
{"token": ["These", "effects", "have", "been", "correlated", "with", "phosphorylation", "of", "the", "eukaryotic", "initiation", "factor", "eIF-2alpha", "and", "the", "NF-kappaB", "inhibitor", "IkappaB", "although", "it", "has", "not", "been", "demonstrated", "that", "C0663914#ent", "<e1>", "is", "a", "direct", "target", "of", "C0058980#ent", "<e2>", "in", "vivo"], "h": {"id": "C0663914", "name": "C0663914#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [32, 33]}}
{"token": ["Thus", ",", "U(S)3", "protein", "kinase", "the", "sole", "C0079405#ent", "<e1>", "to", "block", "activation", "of", "C1413132#ent", "<e2>", "prevent", "cleavage", "of", "poly(ADP-ribose)", "polymerase", "and", "block", "fragmentation", "cellular", "DNA", "induced", "by", "BAD", "."], "h": {"id": "C0079405", "name": "C0079405#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413132", "name": "C1413132#ent", "pos": [13, 14]}}
{"token": ["1", "C0012265#ent", "<e1>", "(", "Lanitop", ")", "300", "microgram/day", "and", "digoxin", "(", "C0699988#ent", "<e2>", ")", "500", "microgram/day", "were", "compared", "in", "cross-over", "studies", "healthy", "volunteers", "on", "patients", "with", "uncontrolled", "atrial", "fibrillation"], "h": {"id": "C0012265", "name": "C0012265#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0699988", "name": "C0699988#ent", "pos": [11, 12]}}
{"token": ["Choroidal", "neovascularisation", "CNV", ")", "and", "C0730328#ent", "<e1>", "ICSC", ")", "are", "recognised", "ocular", "complications", "related", "to", "C0268743#ent", "<e2>"], "h": {"id": "C0730328", "name": "C0730328#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268743", "name": "C0268743#ent", "pos": [15, 16]}}
{"token": ["We", "detected", "G975C", "mutation", "of", "the", "C1417768#ent", "<e1>", "diagnosed", "our", "C0007761#ent", "<e2>", "cerebral", "autosomal", "arteriopathy", "with", "subcortical", "infarcts", "leukoencephalopathy", "(", "CADASIL", ")", "."], "h": {"id": "C1417768", "name": "C1417768#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0007761", "name": "C0007761#ent", "pos": [10, 11]}}
{"token": ["Whether", "TSHR", "is", "involved", "in", "the", "pathogenesis", "of", "C0339143#ent", "<e1>", "TAO", ")", ",", "the", "C0029166#ent", "<e2>", "GD", ",", "remains", "uncertain", "."], "h": {"id": "C0339143", "name": "C0339143#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [14, 15]}}
{"token": ["These", "data", "clearly", "suggest", "that", "the", "N-demethylation", "of", "C0011816#ent", "<e1>", "is", "dependent", "on", "CYP3A", "and", "that", "both", "C3887685#ent", "<e2>", "and", "CYP3A", "are", "involved", "in", "the", "overall", "metabolism", "of", "C0011816#ent", "<e1>", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [17, 18]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [8, 9]}}
{"token": ["PCR-based", "analyses", "of", "DNA", "for", "variants", "of", "the", "C3887685#ent", "<e1>", "that", "the", "PMs", "of", "C0011816#ent", "<e2>", "had", "the", "defective", "allele", "CYP2D6*4"], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [8, 9]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [14, 15]}}
{"token": ["C0939537#ent", "<e1>", "has", "caused", "C0877055#ent", "<e2>"], "h": {"id": "C0939537", "name": "C0939537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0877055", "name": "C0877055#ent", "pos": [4, 5]}}
{"token": ["The", "C0038311#ent", "<e1>", "activity", "of", "intact", "inner", "membranes", "not", "inhibited", "by", "C0960371#ent", "<e2>", "."], "h": {"id": "C0038311", "name": "C0038311#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [11, 12]}}
{"token": ["In", "mice", "exposed", "to", "degrees", "C", "for", "4", "weeks", ",", "acute", "exposure", "to", "severe", "C0041912#ent", "<e1>", "decreased", "the", "glucose", "level", "increased", "the", "levels", "of", "C1417875#ent", "<e2>", "and", "3H-butyrate", "."], "h": {"id": "C0041912", "name": "C0041912#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417875", "name": "C1417875#ent", "pos": [24, 25]}}
{"token": ["C3534573#ent", "<e1>", "the", "most", "common", "vectorborne", "C0679247#ent", "<e2>", "in", "the", "United", "States"], "h": {"id": "C3534573", "name": "C3534573#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0679247", "name": "C0679247#ent", "pos": [6, 7]}}
{"token": ["It", "consists", "of", "two", "C0022895#ent", "<e1>", ",", "BsuMM", "operon", "for", "two", "C0012873#ent", "<e2>", "and", "BsuMR", "operon", "for", "a", "restriction", "nuclease", "two", "associated", "proteins", "of", "unknown", "function", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012873", "name": "C0012873#ent", "pos": [11, 12]}}
{"token": ["However", ",", "rare", "complications", "such", "as", "C0024225#ent", "<e1>", ",", "adenitis", ",", "erythema", "multiforme", "erysipelas", ",", "papulovesicular", "eruption", "C0854135#ent", "<e2>", "and", "bullous", "pemphigoid", "been", "reported", "."], "h": {"id": "C0024225", "name": "C0024225#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0854135", "name": "C0854135#ent", "pos": [17, 18]}}
{"token": ["The", "Ts3", "population", "specifically", "binds", "C1824810#ent", "<e1>", "and", "is", "C0812286#ent", "<e2>", ",", "Lyt-2", "+", ",", "I-J+", "and", "bears", "NPb", "idiotypic", "determinants", "."], "h": {"id": "C1824810", "name": "C1824810#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812286", "name": "C0812286#ent", "pos": [9, 10]}}
{"token": ["c-Met", "overexpression", "correlated", "with", "poor", "survival", "with", "PI3K", "C0059239#ent", "<e1>", "reflecting", "c-Met", "functionality", "and", "CD146", "and", "C1442788#ent", "<e2>", "expression", "in", "endothelial", "cells"], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [16, 17]}}
{"token": ["We", "also", "find", "that", "the", "wild-type", "and", "the", "kinase-defective", "C0059239#ent", "<e1>", "were", "associated", "with", "Src", "and", "C1442788#ent", "<e2>", "in", "CHO", "cells", "the", "F397", "mutant", "was", "not", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [16, 17]}}
{"token": ["IgM", "plaque-forming", "cells", "C3889643#ent", "<e1>", ")", "derived", "from", "such", "activated", "cells", "continue", "to", "express", "both", "antigens", "while", "IgG", "C3889643#ent", "<e1>", "express", "only", "C3272391#ent", "<e1>", "."], "h": {"id": "C3889643", "name": "C3889643#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3272391", "name": "C3272391#ent", "pos": [22, 23]}}
{"token": ["Thromboxane", "A(2)", "a", "potent", "C4255305#ent", "<e1>", "and", "platelet", "agonist", "prostacyclin", "is", "a", "potent", "C0032177#ent", "<e2>", "vasodilator", "."], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032177", "name": "C0032177#ent", "pos": [13, 14]}}
{"token": ["To", "date", ",", "genetic", "variations", "the", "C0537026#ent", "<e1>", "the", "most", "important", "hereditary", "factor", "predict", "severe", "ADR", "to", "C0123931#ent", "<e2>", "."], "h": {"id": "C0537026", "name": "C0537026#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0123931", "name": "C0123931#ent", "pos": [17, 18]}}
{"token": ["The", "C3540779#ent", "<e1>", "cyproheptadine", "and", "methylsergide", ",", "and", "the", "antihistamine", ",", "C0008281#ent", "<e2>", ",", "demonstrated", "marginal", "activity", "the", "Arthus", "pleurisy", "model", "."], "h": {"id": "C3540779", "name": "C3540779#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008281", "name": "C0008281#ent", "pos": [11, 12]}}
{"token": ["The", "patients", "having", "fewer", "C0036572#ent", "<e1>", "on", "C0851183#ent", "<e2>", "had", "higher", "serum", "C0851183#ent", "<e2>", "levels", "than", "those", "doing", "better", "on", "CBZ", ",", "but", "the", "opposite", "was", "found", "for", "the", "CBZ", "levels", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0851183", "name": "C0851183#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", ",", "we", "found", "that", "the", "basic", "C1420632#ent", "<e1>", "which", "usually", "acts", "as", "a", "repressor", "to", "C0079068#ent", "<e2>", ",", "enhances", "insulin", "gene", "transcription"], "h": {"id": "C1420632", "name": "C1420632#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [18, 19]}}
{"token": ["Other", "C1333246#ent", "<e1>", "such", "as", "C1705297#ent", "<e2>", "and", "STAT5", ",", "respond", "differently", "to", "receptor", "activation"], "h": {"id": "C1333246", "name": "C1333246#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [5, 6]}}
{"token": ["The", "fermentation", "kinetics", "of", "C0067320#ent", "<e1>", "production", "from", "whey", "permeate", "a", "packed", "bed", "immobilized", "cell", "bioreactor", "mesophilic", "temperatures", "C0265220#ent", "<e2>", "around", "neutral", "was", "studied", "."], "h": {"id": "C0067320", "name": "C0067320#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0265220", "name": "C0265220#ent", "pos": [18, 19]}}
{"token": ["We", "report", "the", "C0012798#ent", "<e1>", ",", "natriuretic", "and", "kaliuretic", "effects", "of", "C0011777#ent", "<e2>", "(", "DEXA", ")", "on", "intact", "and", "adrenalectomized", "(", "ADX", ")", "male", "Wistar", "rats"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [11, 12]}}
{"token": ["The", "common", "community-based", "rheumatic", "diseases", "are", "not", "C0003873#ent", "<e1>", "or", "SLE", "that", "dominate", "admissions", "to", "C0003864#ent", "<e2>", "clinics", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [15, 16]}}
{"token": ["Partial", "sequence", "Edman", "degradation", "peptide", "fragments", "by", "digestion", "of", "C3539613#ent", "<e1>", "with", "cyanogen", "bromide", "C0960371#ent", "<e2>", "demonstrates", "that", "C3539613#ent", "<e1>", "contains", "regions", "of", "sequence", "identity", "to", "that", "deduced", "from", "the", "granulin", "or", "epithelin", "precursor", "cDNAs", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3539613", "name": "C3539613#ent", "pos": [9, 10]}}
{"token": ["We", "present", "a", "patient", "with", "macrothrombocytopenia", ",", "C0017658#ent", "<e1>", ",", "progressive", "uraemia", "and", "progressive", "sensorineural", "deafness", "associated", "with", "C0392775#ent", "<e2>", "the", "ascending", "aorta", "malformation", "of", "the", "aortic", "valves"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0392775", "name": "C0392775#ent", "pos": [18, 19]}}
{"token": ["We", "present", "evidence", "that", "the", "transcriptional", "antagonist", "CRE", "modulator", "(", "C1413706#ent", "<e1>", ")", "can", "bind", "to", "C0087140#ent", "<e2>", "CRE", "and", "heterodimerize", "with", "activator", "CRE-binding", "protein", "thereby", "blocking", "cAMP", "induction", "."], "h": {"id": "C1413706", "name": "C1413706#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [16, 17]}}
{"token": ["The", "arrhythmogenic", "doses", "phenylephrine", "and", "isoproterenol", "were", "determined", "during", "the", "two", "anesthetic", "methods", "the", "effect", "of", "C0936073#ent", "<e1>", "on", "the", "arrhythmogenic", "action", "alpha", "1", "C2987634#ent", "<e2>", "examined", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [24, 25]}}
{"token": ["Conductance", "changes", "produced", "by", "bath", "applied", "agonists", "were", "depressed", "by", "C0936073#ent", "<e1>", ",", "the", "effect", "becoming", "greater", "the", "higher", "the", "C2987634#ent", "<e2>", "concentration", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [20, 21]}}
{"token": ["C2020625#ent", "<e1>", "group", "B", "Streptococcus", "is", "the", "major", "cause", "of", "invasive", "C0004623#ent", "<e2>", "including", "meningitis", ",", "in", "the", "neonatal", "period", "."], "h": {"id": "C2020625", "name": "C2020625#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [11, 12]}}
{"token": ["This", "was", "shown", "to", "result", "partly", "from", "the", "decrease", "of", "C1420306#ent", "<e1>", "catalase", "activities", "age", ",", "concurrently", "with", "age-related", "decrease", "of", "particulate", "C1415275#ent", "<e2>", "glutathione", "reductase", "activities", "."], "h": {"id": "C1420306", "name": "C1420306#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415275", "name": "C1415275#ent", "pos": [22, 23]}}
{"token": ["Moreover", ",", "these", "activities", "of", "C0950716#ent", "<e1>", "are", "associated", "with", "sensitization", "of", "tumor", "cells", "C0033978#ent", "<e2>", "resulting", "in", "their", "increased", "apoptosis", "."], "h": {"id": "C0950716", "name": "C0950716#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "indicates", "the", "importance", "of", "comparative", "surface", "and", "cytoplasmic", "immunophenotyping", "C2986617#ent", "<e1>", "and", "CD33", "mAbs", "for", "the", "diagnosis", "of", "subgroups", "of", "C3273937#ent", "<e2>", "."], "h": {"id": "C2986617", "name": "C2986617#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273937", "name": "C3273937#ent", "pos": [23, 24]}}
{"token": ["Binding", "of", "corticosteroids", "to", "the", "C1334899#ent", "<e1>", "GR", ")", "stimulated", "phosphatidylinositol", "3-kinase", "protein", "kinase", "Akt", "leading", "to", "C1328053#ent", "<e2>", "activation", "and", "nitric", "oxide", "vasorelaxation", "."], "h": {"id": "C1334899", "name": "C1334899#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [17, 18]}}
{"token": ["The", "role", "of", "C1334899#ent", "<e1>", "mediation", "in", "betamethasone-induced", "C1328053#ent", "<e2>", "changes", "was", "investigated", "with", "the", "glucocorticoid", "receptor", "antagonist", "mifepristone", "."], "h": {"id": "C1334899", "name": "C1334899#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [8, 9]}}
{"token": ["E-cad", "and", "beta-cat", "correlated", "with", "high", "expression", "of", "P53", ",", "of", "C0242957#ent", "<e1>", ",", "and", "of", "C1708825#ent", "<e2>", "and", "with", "lack", "of", "hormone", "receptors", "sites", "(", "p<0.001", ")", "."], "h": {"id": "C0242957", "name": "C0242957#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1708825", "name": "C1708825#ent", "pos": [16, 17]}}
{"token": ["Recent", "studies", "using", "linkage", "disequilibrium", "SNPs", "uncovered", "a", "C0038013#ent", "<e1>", "haplotype", "in", "the", "C0079429#ent", "<e2>", "encoding", "peptidylarginine", "deiminase", "PADI", ")", "type", "4", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["These", "axonopathies", "are", "excellent", "experimental", "models", "the", "giant", "C0270921#ent", "<e1>", "a", "group", "of", "acquired", "and", "inherited", "C0012634#ent", "<e2>", "the", "central", "and", "peripheral", "nervous", "system"], "h": {"id": "C0270921", "name": "C0270921#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [16, 17]}}
{"token": ["Low", "plasma", "zinc", "and", "high", "copper", "levels", "have", "been", "observed", "in", "various", "C0023895#ent", "<e1>", "such", "as", "liver", "cirrhosis", "C0019159#ent", "<e2>", "while", "increased", "oestradiol", "levels", "have", "been", "documented", "in", "chronic", "liver", "damage", "hepatocellular", "carcinoma"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [18, 19]}}
{"token": ["The", "volume", "of", "C1416171#ent", "<e1>", "was", "not", "changed", "after", "administration", "of", "C0771315#ent", "<e2>", "and", "feeding", "the", "diet", "."], "h": {"id": "C1416171", "name": "C1416171#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0771315", "name": "C0771315#ent", "pos": [11, 12]}}
{"token": ["Other", "host", "factors", "for", "the", "regulation", "by", "SgrS", "include", "the", "C0950398#ent", "<e1>", "components", "of", "the", "RNA", "degradosome", "particularly", "C1414402#ent", "<e2>", ",", "a", "glycolytic", "enzyme", "role", "in", "RNA", "degradation", "is", "currently", "not", "understood", "."], "h": {"id": "C0950398", "name": "C0950398#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414402", "name": "C1414402#ent", "pos": [18, 19]}}
{"token": ["A", "majority", "of", "LCs", "(", "70", "%", ")", "expressed", "the", "C1442491#ent", "<e1>", "whereas", "DCs", "did", "not", "express", "C1442491#ent", "<e1>"], "h": {"id": "C1442491", "name": "C1442491#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1442491", "name": "C1442491#ent", "pos": [10, 11]}}
{"token": ["In", "brief", ",", "submaxillaritis", "accompanied", "by", "C0018202#ent", "<e1>", "be", "regarded", "as", "a", "Type", "III", "allergic", "response", "by", "immunological", "abnormalities", "are", "C1516876#ent", "<e2>", "determined", "by", "the", "lpr", "gene", "it", "is", "thought", "to", "be", "a", "subtype", "of", "immune", "complex", "disease"], "h": {"id": "C0018202", "name": "C0018202#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [20, 21]}}
{"token": ["Her", "C0018801#ent", "<e1>", "improved", "with", "digoxin", ",", "furosemide", ",", "and", "C0014025#ent", "<e2>", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [10, 11]}}
{"token": ["This", "study", "provides", "a", "rational", "basis", "for", "the", "use", "of", "the", "specific", "aldosterone", "inhibitor", "C0037982#ent", "<e1>", "in", "the", "treatment", "of", "patients", "with", "advanced", "metastatic", "liver", "disease", "C0013604#ent", "<e2>"], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [26, 27]}}
{"token": ["CFS", "is", "characterized", "by", "debilitating", "fatigue", "with", "associated", "C0032238#ent", "<e1>", ",", "tender", "lymph", "nodes", "arthralgias", ",", "chills", ",", "C0015967#ent", "<e2>", "feelings", ",", "and", "postexertional", "malaise", "."], "h": {"id": "C0032238", "name": "C0032238#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "in", "cells", "treated", "with", "etidronate", ",", "but", "not", "alendronate", "or", "risedronate", ",", "C0383779#ent", "<e1>", "also", "prevented", "actin", "disruption", "an", "early", "sign", "osteoclast", "inhibition", "by", "C0012544#ent", "<e2>", "."], "h": {"id": "C0383779", "name": "C0383779#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [26, 27]}}
{"token": ["Sesquiterpene", "lactones", "to", "be", "the", "most", "important", "C1417708#ent", "<e1>", "inhibiting", "compounds", "in", "the", "C0555881#ent", "<e2>"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0555881", "name": "C0555881#ent", "pos": [13, 14]}}
{"token": ["In", "20", "children", "with", "C1426204#ent", "<e1>", "numbers", "of", "IgA", "C0071561#ent", "<e2>", "SFC", "increased", "rapidly", "(", "p", "<", "0.0001", ")", "after", "gluten", "challenge", "."], "h": {"id": "C1426204", "name": "C1426204#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0071561", "name": "C0071561#ent", "pos": [9, 10]}}
{"token": ["As", "observed", "with", "other", "DNA-specific", "agents", ",", "induction", "of", "C1424252#ent", "<e1>", "differentiation", "by", "C0127444#ent", "<e2>", "was", "accompanied", "by", "the", "down-regulation", "of", "c-myb", "gene", "."], "h": {"id": "C1424252", "name": "C1424252#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0127444", "name": "C0127444#ent", "pos": [13, 14]}}
{"token": ["This", "analysis", "suggests", "a", "potential", "mechanism", "of", "C1336778#ent", "<e1>", "the", "neuronally", "expressed", "C1417679#ent", "<e2>", "investigated", "in", "this", "study", "and", "also", "demonstrates", "that", "multiple", "factors", "involved", "in", "transcriptional", "activation", "cAMP", "."], "h": {"id": "C1336778", "name": "C1336778#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["pVHL19", "is", "a", "C0023689#ent", "<e1>", "promoting", "proteosomal", "degradation", "of", "hypoxia-inducible", "factor-1alpha", "C1333897#ent", "<e2>", ")", ";", "pVHL30", "is", "associated", "with", "microtubules", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [11, 12]}}
{"token": ["A", "coupled", "assay", "to", "measure", "2-methyl-acyl", "C0034503#ent", "<e1>", "was", "developed", "by", "using", "purified", "rat", "C1412130#ent", "<e2>"], "h": {"id": "C0034503", "name": "C0034503#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412130", "name": "C1412130#ent", "pos": [14, 15]}}
{"token": ["Children", "with", "early-onset", "diabetes", "had", "a", "significantly", "higher", "incidence", "of", "C0042769#ent", "<e1>", "symptoms", "(", "p=0.005", ")", "and", "C0011880#ent", "<e2>", "DKA", ";", "p=0.017", ")", "at", "the", "time", "of", "diagnosis", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011880", "name": "C0011880#ent", "pos": [17, 18]}}
{"token": ["Investigations", "of", "C4025182#ent", "<e1>", "increases", "in", "C1337111#ent", "<e2>", ",", "adrenocorticotropic", "hormone", "ACTH", ")", "and", "cortisol", "concentration", "been", "carried", "out", "mainly", "in", "men", "."], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [6, 7]}}
{"token": ["Investigations", "of", "C4025182#ent", "<e1>", "increases", "in", "beta-endorphin", ",", "C1337111#ent", "<e2>", "ACTH", ")", "and", "cortisol", "concentration", "been", "carried", "out", "mainly", "in", "men", "."], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "pregnancy", "seems", "to", "accentuate", "the", "C4025182#ent", "<e1>", "increase", "in", "C1337111#ent", "<e2>", "."], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [11, 12]}}
{"token": ["In", "particular", ",", "they", "expressed", "C0022564#ent", "<e1>", "intermediate", "filaments", "acquired", "the", "ability", "to", "synthesise", "simian", "virus", "tumor", "antigens", "C0042769#ent", "<e2>"], "h": {"id": "C0022564", "name": "C0022564#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [18, 19]}}
{"token": ["In", "pigeons", ",", "C0916648#ent", "<e1>", "dose-dependently", "blocked", "the", "stimulus", "cue", "induced", "by", "C0050079#ent", "<e2>", "but", "had", "no", "8-OH-DPAT-like", "discriminative", "properties", "."], "h": {"id": "C0916648", "name": "C0916648#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0050079", "name": "C0050079#ent", "pos": [12, 13]}}
{"token": ["With", "the", "exception", "of", "dichloromethane", "and", "C0012066#ent", "<e1>", ",", "all", "the", "compounds", "decreased", "the", "ethoxycoumarin", "deethylase", "activity", "the", "C0027203#ent", "<e2>", "in", "a", "time-", "and", "NADPH-dependent", "manner", "."], "h": {"id": "C0012066", "name": "C0012066#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [18, 19]}}
{"token": ["Presentations", "of", "C0525678#ent", "<e1>", "in", "CHF", "include", "C0034063#ent", "<e2>", "hypertension", ",", "worsening", "of", "CHF", ",", "and", "worsening", "renal", "function"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [7, 8]}}
{"token": ["Mesophyll", "cells", "isolated", "from", "control", "leaves", "contained", "no", "activity", "PAL", ",", "C0007965#ent", "<e1>", ",", "or", "IGT", "and", "no", "C1257966#ent", "<e2>", "of", "any", "class", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1257966", "name": "C1257966#ent", "pos": [18, 19]}}
{"token": ["Although", "most", "C0268135#ent", "<e1>", "patients", "such", "as", "XP12RO", "have", "severe", "C1457887#ent", "<e2>", "neurological", "abnormalities", "the", "de", "Sanctis-Cacchione", "syndrome", "patient", "XP39OS", "was", "an", "atypical", "C0268135#ent", "<e1>", "patient", "who", "had", "mild", "skin", "symptoms", "minimal", "neurological", "abnormalities"], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268135", "name": "C0268135#ent", "pos": [2, 3]}}
{"token": ["Although", "OA", "is", "defined", "as", "a", "C0162323#ent", "<e1>", "proinflammatory", "cytokines", "as", "interleukin-1", "have", "been", "implicated", "as", "important", "C0127400#ent", "<e2>", "in", "the", "disease", "."], "h": {"id": "C0162323", "name": "C0162323#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "C0120541#ent", "<e1>", "Ser-83", "to", "Leu", "is", "implicated", "in", "C0358919#ent", "<e2>", "S.", "dysenteriae", "type", "1", "."], "h": {"id": "C0120541", "name": "C0120541#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0358919", "name": "C0358919#ent", "pos": [10, 11]}}
{"token": ["Hepatic", "carnitine", "palmitoyltransferase", "I", "CPT", "IA", ")", "is", "one", "of", "the", "C0026794#ent", "<e1>", "of", "CPT", "I", "and", "its", "deficiency", "results", "in", "an", "autosomal", "C0017361#ent", "<e2>", "mitochondrial", "fatty", "acid", "oxidation", "disorder"], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [23, 24]}}
{"token": ["The", "C0293352#ent", "<e1>", "content", "of", "GRP", "was", "significantly", "decreased", "12", "h", "after", "C0771315#ent", "<e2>", "administration", "and", "thereafter", "gradually", "returned", "to", "control", "levels"], "h": {"id": "C0293352", "name": "C0293352#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0771315", "name": "C0771315#ent", "pos": [12, 13]}}
{"token": ["Four", "restriction", "fragment", "length", "polymorphisms", "RFLP", ")", "were", "typed", "on", "the", "C0015683#ent", "<e1>", "MspI/pF5", ")", ",", "on", "the", "C4283949#ent", "<e2>", "HindIII/em", ")", ",", "as", "well", "as", "on", "the", "acetyl", "coenzyme", "A", "carboxylase", "delta9", "desaturase", "genes"], "h": {"id": "C0015683", "name": "C0015683#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4283949", "name": "C4283949#ent", "pos": [18, 19]}}
{"token": ["C0155490#ent", "<e1>", "of", "the", "external", "auditory", "canal", "EAC", ")", "in", "C1399354#ent", "<e2>", "not", "been", "reported", "before", "."], "h": {"id": "C0155490", "name": "C0155490#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1399354", "name": "C1399354#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "C0890491#ent", "<e1>", "is", "involved", "in", "C0004135#ent", "<e2>", "activation", "in", "response", "to", "DNA", "damage", "acetylation", "of", "p53", "by", "C0890491#ent", "<e1>", "influences", "the", "cell", "'s", "decision", "to", "undergo", "apoptosis", "instead", "of", "a", "cell", "cycle", "arrest"], "h": {"id": "C0890491", "name": "C0890491#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "C0890491#ent", "<e1>", "influences", "the", "function", "of", "C0004135#ent", "<e2>", "."], "h": {"id": "C0890491", "name": "C0890491#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [10, 11]}}
{"token": ["To", "further", "define", "the", "interaction", "between", "C1705281#ent", "<e1>", "and", "beta-catenin", ",", "we", "identified", "a", "serine-rich", "motif", "(", "C1420406#ent", "<e2>", ")", "in", "the", "C1705281#ent", "<e1>", "cytoplasmic", "domain", "binds", "directly", "to", "beta-catenin", "Armadillo", "repeats"], "h": {"id": "C1420406", "name": "C1420406#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [6, 7]}}
{"token": ["Finally", ",", "recent", "experience", "supporting", "ileocolic", "resection", "C0010346#ent", "<e1>", "identified", "during", "laparotomy", "for", "C0694551#ent", "<e2>", "critically", "evaluated", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0694551", "name": "C0694551#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "C0772415#ent", "<e1>", "causes", "less", "inhibition", "of", "C0008429#ent", "<e2>", "because", "testosterone", "may", "interfere", "with", "its", "entry", "into", "the", "brain", "."], "h": {"id": "C0772415", "name": "C0772415#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008429", "name": "C0008429#ent", "pos": [9, 10]}}
{"token": ["The", "C1413167#ent", "<e1>", "(", "CCK", ")", "2", "receptor", "(", "C1707081#ent", "<e2>", ")", "appears", "as", "a", "pharmacological", "target", "for", "the", "treatment", "of", "many", "major", "diseases", "."], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1707081", "name": "C1707081#ent", "pos": [9, 10]}}
{"token": ["The", "C1413167#ent", "<e1>", "(", "CCK", ")", "receptors", "CCK1R", "and", "C1707081#ent", "<e2>", "exert", "important", "central", "and", "peripheral", "functions", "binding", "the", "neuropeptide", "cholecystokinin"], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1707081", "name": "C1707081#ent", "pos": [9, 10]}}
{"token": ["C0035204#ent", "<e1>", "childhood", "may", "predispose", "to", "C0024115#ent", "<e2>", "late", "adult", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [6, 7]}}
{"token": ["Data", "are", "presented", "on", "the", "coverage", "of", "outpatient", "follow-up", "of", "patients", "with", "nonspecific", "C0035204#ent", "<e1>", "on", "mortality", "from", "all", "nonspecific", "C0024115#ent", "<e2>", "pneumonia", "for", "1986", "-", "1989", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [20, 21]}}
{"token": ["We", "have", "now", "tested", "whether", "C0525129#ent", "<e1>", "ameliorates", "established", "C2711227#ent", "<e2>", "and", "fibrosis", "."], "h": {"id": "C0525129", "name": "C0525129#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [9, 10]}}
{"token": ["C2983558#ent", "<e1>", "-", "1", "was", "not", "only", "tolerant", "to", "Phe", ",", "C4048300#ent", "<e2>", ",", "and", "Trp", ",", "but", "also", "to", "other", ",", "not", "biosynthetically", "related", "amino", "acids"], "h": {"id": "C2983558", "name": "C2983558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4048300", "name": "C4048300#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "case", "in", "which", "we", "used", "a", "new", "C0035326#ent", "<e1>", "amplatzer", "vascular", "plug", ",", "to", "occlude", "a", "C0155675#ent", "<e2>", "a", "patient", "with", "Rendu-Osler-Weber", "syndrome"], "h": {"id": "C0035326", "name": "C0035326#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0155675", "name": "C0155675#ent", "pos": [19, 20]}}
{"token": ["The", "B", "chain", "C1705562#ent", "<e1>", "contains", "the", "catalytic", "portion", "the", "C0027203#ent", "<e2>", "and", "is", "homologous", "to", "the", "trypsin", "family", "of", "serine", "proteases"], "h": {"id": "C1705562", "name": "C1705562#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["We", "searched", "for", "innovative", "treatments", "specifically", "targeted", "to", "the", "cytokines", "of", "three", "C0010340#ent", "<e1>", "patients", "with", "C0600327#ent", "<e2>", "STSS", ")", "."], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0600327", "name": "C0600327#ent", "pos": [16, 17]}}
{"token": ["The", "patient", "was", "confirmed", "as", "having", "late-onset", "C3889972#ent", "<e1>", "and", "treated", "with", "anticonvulsants", ",", "C0022957#ent", "<e2>", "protein", "restricted", "diet", "and", "arginine", "."], "h": {"id": "C3889972", "name": "C3889972#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022957", "name": "C0022957#ent", "pos": [14, 15]}}
{"token": ["Results", "showed", "that", "C0020615#ent", "<e1>", "is", "higher", "and", "C0020459#ent", "<e2>", "rises", "more", "slowly", "in", "the", "elderly", ",", "while", "serum", "glucagon", "values", "show", "no", "substantial", "variations", "in", "the", "two", "groups", "of", "subjects", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020459", "name": "C0020459#ent", "pos": [8, 9]}}
{"token": ["The", "septin", "Hcdc10", "localizes", "to", "these", "ectopic", "foci", ",", "whereas", "C0949684#ent", "<e1>", "actin", "do", "not", ",", "suggesting", "that", "C3541860#ent", "<e2>", "interacts", "with", "the", "septins", "at", "the", "cortex", "."], "h": {"id": "C0949684", "name": "C0949684#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3541860", "name": "C3541860#ent", "pos": [18, 19]}}
{"token": ["We", "show", "that", "C0030956#ent", "<e1>", "not", "impair", "the", "C1997362#ent", "<e2>", "NSC", "progeny", ",", "but", "that", "it", "increases", "the", "total", "number", "of", "neurons", "in", "vitro", "a", "dose-dependent", "manner", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1997362", "name": "C1997362#ent", "pos": [8, 9]}}
{"token": ["We", "used", "light", "microscopic", "immunohistochemistry", "to", "locate", "manganese", "superoxide", "dismutase", "copper", "zinc", "superoxide", "dismutase", "C0007367#ent", "<e1>", ",", "and", "glutathione-S-transferases", "in", "C0029453#ent", "<e2>", "rats", "of", "4", "-", "14", "weeks", "of", "age", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029453", "name": "C0029453#ent", "pos": [20, 21]}}
{"token": ["Antibodies", "against", "adiponectin", "receptor", "and", "C3537285#ent", "<e1>", "elicit", "activation", "of", "C2986464#ent", "<e2>", "or", "AP-1", ",", "two", "redox-sensitive", "transcription", "factors", "."], "h": {"id": "C3537285", "name": "C3537285#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [10, 11]}}
{"token": ["Database", "homology", "searches", "revealed", "two", "additional", "uncharacterized", "cDNAs", "similar", "to", "C1412787#ent", "<e1>", "that", "were", "named", "Bex2", "and", "C1705044#ent", "<e2>", "."], "h": {"id": "C1412787", "name": "C1412787#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705044", "name": "C1705044#ent", "pos": [17, 18]}}
{"token": ["The", "levels", "of", "circulating", "glucose", ",", "amino", "acids", "lactate", ",", "urea", "and", "ammonium", "were", "measured", "as", "well", "as", "C0017920#ent", "<e1>", "tissue", "amino", "acids", "the", "liver", "and", "muscle", "activities", "C1413683#ent", "<e2>", "II", ",", "glutamate", "dehydrogenase", "glutamine", "synthetase", "adenylate", "deaminase"], "h": {"id": "C0017920", "name": "C0017920#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1413683", "name": "C1413683#ent", "pos": [28, 29]}}
{"token": ["These", "treatments", "decreased", "the", "expression", "of", "CD11a", "and", "C1334146#ent", "<e1>", ",", "whereas", "that", "of", "CD29", "or", "C1704693#ent", "<e2>", "was", "not", "markedly", "changed", "."], "h": {"id": "C1334146", "name": "C1334146#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704693", "name": "C1704693#ent", "pos": [16, 17]}}
{"token": ["These", "data", "suggest", "that", "C1706339#ent", "<e1>", "is", "the", "primary", "mediator", "of", "the", "actions", "of", "C1868677#ent", "<e2>", "in", "growth", "plate", "chondrocytes", "and", "that", "there", "is", "haploinsufficiency", "of", "Gsalpha", "signaling", "in", "Gnas(+/E2-", ")", "chondrocytes", "."], "h": {"id": "C1706339", "name": "C1706339#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1868677", "name": "C1868677#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "describe", "a", "fatal", "case", "of", "C0264515#ent", "<e1>", "a", "14-year-old", "child", "who", "presented", "initially", "with", "C0242429#ent", "<e2>", "pyrexia", "."], "h": {"id": "C0264515", "name": "C0264515#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242429", "name": "C0242429#ent", "pos": [17, 18]}}
{"token": ["The", "latter", "were", "characterized", "by", "a", "faster", "development", "of", "the", "C0027743#ent", "<e1>", "signs", "of", "C0151740#ent", "<e2>", "secondary", "stem", "symptoms", "."], "h": {"id": "C0027743", "name": "C0027743#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [14, 15]}}
{"token": ["Twenty-three", "of", "them", "had", "upper", "respiratory", "tract", "infections", "cough", "and", "fever", ";", "two", "had", "C1535939#ent", "<e1>", ",", "one", "with", "C0027134#ent", "<e2>", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027134", "name": "C0027134#ent", "pos": [19, 20]}}
{"token": ["Consistent", "with", "interpretation", ",", "C1415760#ent", "<e1>", "coprecipitated", "with", "C0079423#ent", "<e2>", "from", "HIV-1-infected", "cells", "."], "h": {"id": "C1415760", "name": "C1415760#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079423", "name": "C0079423#ent", "pos": [8, 9]}}
{"token": ["The", "increase", "of", "telomerase", "activity", "C1704887#ent", "<e1>", "is", "blocked", "by", "the", "presence", "of", "the", "C1709402#ent", "<e2>", "LY294002", "."], "h": {"id": "C1704887", "name": "C1704887#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "during", "trophoblast", "invasion", "extravillous", "cytotrophoblasts", "C3538699#ent", "<e1>", "expressing", "the", "alpha", "6", "integrin", "subunit", "the", "invasive", "population", "cells", "(", "C0172537#ent", "<e2>", "low", "fibronectin", "secretion", ")", "."], "h": {"id": "C3538699", "name": "C3538699#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0172537", "name": "C0172537#ent", "pos": [21, 22]}}
{"token": ["Many", "of", "these", "lesions", "involved", "recurrent", "(", "partially", ")", "overlapping", "deletions", "and", "duplications", ",", "containing", "various", "established", "C1705557#ent", "<e1>", "such", "as", "ETV6", ",", "C1335654#ent", "<e2>", "and", "MLL", "."], "h": {"id": "C1705557", "name": "C1705557#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [23, 24]}}
{"token": ["Orthostatic", "circulatory", "disorders", "a", "common", "problem", "in", "the", "mobilization", "of", "patients", "with", "severe", "C0027765#ent", "<e1>", "as", "paraplegia", ",", "the", "C0242670#ent", "<e2>", "the", "minimally", "conscious", "state"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242670", "name": "C0242670#ent", "pos": [19, 20]}}
{"token": ["Additionally", ",", "cigarette", "smoking", "a", "direct", "cause", "of", "C0151744#ent", "<e1>", "the", "commonest", "cause", "of", "death", "in", "western", "countries", ",", "respiratory", "heart", "disease", "C0340629#ent", "<e2>", "chronic", "obstructive", "lung", "disease", "stroke", ",", "pneumonia", "and", "cirrhosis", "and", "cancer", "of", "the", "liver", "."], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0340629", "name": "C0340629#ent", "pos": [22, 23]}}
{"token": ["Cigarette", "smoking", "known", "to", "be", "a", "strong", "risk", "factor", "several", "cardiovascular", "diseases", "as", "C0151744#ent", "<e1>", "stroke", ",", "intermittent", "claudication", "and", "C0340629#ent", "<e2>"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0340629", "name": "C0340629#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "whether", "these", "agents", "and", "the", "C0162756#ent", "<e1>", "ondansetron", "can", "inhibit", "C0008354#ent", "<e2>", "toxin-induced", "secretion", "in", "the", "human", "jejunum", "using", "a", "segmental", "perfusion", "technique", "."], "h": {"id": "C0162756", "name": "C0162756#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008354", "name": "C0008354#ent", "pos": [12, 13]}}
{"token": ["Our", "patient", "was", "a", "72-year-old", "man", "with", "advanced", "Parkinson's", "disease", "C3160718#ent", "<e1>", ")", "who", "received", "levodopa", "and", "C0242893#ent", "<e2>", "whose", "head", "had", "become", "almost", "completely", "bald", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [17, 18]}}
{"token": ["She", "was", "diagnosed", "as", "Parkinson's", "disease", "C3160718#ent", "<e1>", ")", "and", "was", "treated", "with", "C0242893#ent", "<e2>"], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [13, 14]}}
{"token": ["It", "has", "been", "also", "discovered", "that", "the", "action", "of", "phenazepam", "and", "diazepam", "is", "potentiated", "by", "C0037567#ent", "<e1>", "and", "reduced", "by", "thiosemicarbazide", "and", "C0005372#ent", "<e2>", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0005372", "name": "C0005372#ent", "pos": [22, 23]}}
{"token": ["Immunofluorescence", "studies", "carried", "out", "using", "antibodies", "and", "antisera", "against", "integral", "membrane", "proteins", "vesicle", "associated", "proteins", ",", "C1417815#ent", "<e1>", ",", "and", "the", "enzymes", "TH", "and", "C3541302#ent", "<e2>", "."], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3541302", "name": "C3541302#ent", "pos": [24, 25]}}
{"token": ["In", "conclusion", ",", "this", "study", "suggests", "that", "a", "combination", "of", "CLA", "with", "C0248719#ent", "<e1>", "may", "modify", "several", "risk", "factors", "cardiovascular", "disease", "seen", "in", "C0524620#ent", "<e2>"], "h": {"id": "C0248719", "name": "C0248719#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [23, 24]}}
{"token": ["We", "have", "used", "a", "transgenic", "mice", "expressing", "the", "1.5", "kb", "promoter", "of", "the", "human", "C1413865#ent", "<e1>", "gene", "fused", "to", "the", "C0311727#ent", "<e2>", "order", "to", "investigate", "tissue-specific", "C1413865#ent", "<e1>", "expression", "."], "h": {"id": "C1413865", "name": "C1413865#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0311727", "name": "C0311727#ent", "pos": [20, 21]}}
{"token": ["In", "group", "I", "the", "underlying", "diseases", "were", "C0264220#ent", "<e1>", "and", "in", "group", "II", "C0264220#ent", "<e1>", "other", "significant", "diseases", "such", "as", "diabetes", "mellitus", "cardiovascular", "diseases", "C0162429#ent", "<e1>", "or", "malignancy", "."], "h": {"id": "C0264220", "name": "C0264220#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [24, 25]}}
{"token": ["In", "44", "patients", "with", "acute", "renal", "failure", "serum", "prolactin", "were", "estimated", "using", "C0033399#ent", "<e1>", "as", "a", "C0002763#ent", "<e2>", "and", "alfa-bromocriptine", "as", "an", "inhibitory", "agent"], "h": {"id": "C0033399", "name": "C0033399#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [16, 17]}}
{"token": ["Domain", "2", "carboxypeptidase", "Y", "CPY", ")", ",", "proteinase", "A", "C3274822#ent", "<e1>", ")", "and", "hybrids", "of", "these", "proteases", "with", "C0053409#ent", "<e2>", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0053409", "name": "C0053409#ent", "pos": [18, 19]}}
{"token": ["Since", "ethanol", "reduced", "C1705725#ent", "<e1>", "but", "not", "C1321914#ent", "<e2>", "superoxide", "ion", "O2-", ")", "formation", "by", "PMNL", ",", "the", "effects", "of", "ethanol", "on", "second", "messenger", "systems", "PMNL", "were", "studied", "."], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [7, 8]}}
{"token": ["In", "addition", ",", "the", "studies", "reported", "in", "this", "paper", "provide", "the", "first", "definitive", "characterization", "of", "oxidations", "on", "specific", "C3539946#ent", "<e1>", "the", "D1", "and", "C1538717#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1538717", "name": "C1538717#ent", "pos": [23, 24]}}
{"token": ["Incubation", "of", "FVIII-EH", "plasma", "with", "penicillamine", "or", "C0012789#ent", "<e1>", "causes", "a", "five-", "to", "sixfold", "increase", "in", "C2732002#ent", "<e2>", "C", ",", "at", "80", "and", "1", "mM", ",", "respectively", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2732002", "name": "C2732002#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "a", "total", "of", "86", "patients", "with", "newly", "diagnosed", "C0020538#ent", "<e1>", "echocardiographic", "evidence", "of", "left", "ventricular", "hypertrophy", "randomized", "treatment", "C0006938#ent", "<e2>", "(", "n", "=", "43", ")", "or", "nitrendipine", "(", "n", "=", "43", ")", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [20, 21]}}
{"token": ["Pairwise", "comparisons", "indicated", "the", "C0717442#ent", "<e1>", "combination", "was", "statistically", "superior", "C0004057#ent", "<e2>", "650", "mg", "alone", "for", "hours", "of", "50", "%", "relief", "among", "patients", "who", "had", "severe", "baseline", "pain"], "h": {"id": "C0717442", "name": "C0717442#ent", "pos": [4, 5]}, "relation": "has_constitutional_part", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [10, 11]}}
{"token": ["C0175778#ent", "<e1>", "known", "to", "have", "an", "association", "with", "laryngomalacia", "and", "C0948187#ent", "<e2>", "."], "h": {"id": "C0175778", "name": "C0175778#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0948187", "name": "C0948187#ent", "pos": [10, 11]}}
{"token": ["Against", "pulmonary", "candidiasis", "C0010414#ent", "<e1>", ",", "ER-30346", "was", "more", "effective", "than", "C0064113#ent", "<e2>", "and", "was", "as", "effective", "as", "fluconazole", "."], "h": {"id": "C0010414", "name": "C0010414#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [11, 12]}}
{"token": ["Prevention", "of", "relapses", "of", "C0010414#ent", "<e1>", "was", "obtained", "in", "all", "patients", "with", "AIDS", "on", "long-term", "C0064113#ent", "<e2>", "monotherapy", "(", "3", "mg/kg", ")", "."], "h": {"id": "C0010414", "name": "C0010414#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [15, 16]}}
{"token": ["The", "lyophilized", "cells", "of", "all", "of", "the", "C1875400#ent", "<e1>", "exhibited", "high", "binding", "activity", "C0077413#ent", "<e2>", ",", "Trp-P-2", ",", "MeA", "alpha", "C", "and", "PhIP", ",", "while", "Glu-P-1", "and", "IQ", "were", "not", "effectively", "bound", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0077413", "name": "C0077413#ent", "pos": [13, 14]}}
{"token": ["The", "peptidoglycan", ",", "outer", "membrane", "and", "glucan", "C1875400#ent", "<e1>", "from", "the", "cell", "wall", "skeletons", "the", "highest", "binding", "ability", "to", "C0077413#ent", "<e2>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0077413", "name": "C0077413#ent", "pos": [19, 20]}}
{"token": ["The", "abnormal", "myosin", "localization", "seen", "in", "the", "C1416491#ent", "<e1>", "null", "mutant", "restored", "to", "C2987364#ent", "<e2>", "localization", "by", "expression", "of", "all", "three", "C1416491#ent", "<e1>", "mutants", "."], "h": {"id": "C1416491", "name": "C1416491#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}}
{"token": ["Sequence", "analysis", "C0079941#ent", "<e1>", "all", "structural", "and", "accessory", "genes", "from", "C0079405#ent", "<e2>", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079405", "name": "C0079405#ent", "pos": [10, 11]}}
{"token": ["Rifamycin", "SV", "compared", "with", "C0040866#ent", "<e1>", "a", "randomized", "controlled", "trial", "87", "patients", "with", "C0038013#ent", "<e2>", "with", "persistent", "knee", "synovitis"], "h": {"id": "C0040866", "name": "C0040866#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [13, 14]}}
{"token": ["Activated", "caspase-9", "and", "C0291573#ent", "<e1>", "activities", "were", "present", "only", "at", "C0679247#ent", "<e2>"], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0679247", "name": "C0679247#ent", "pos": [10, 11]}}
{"token": ["The", "high", "incidence", "of", "MesPGN", "and", "C0017662#ent", "<e1>", "may", "result", "from", "environmental", "factors", "as", "chronic", "infection", "C0162429#ent", "<e2>", "."], "h": {"id": "C0017662", "name": "C0017662#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [16, 17]}}
{"token": ["We", "present", "the", "cranial", "MRI", "findings", "in", "a", "6-month-old", "girl", "with", "C0268250#ent", "<e1>", "which", "include", "C0235946#ent", "<e2>", "dural", "thickening", "contrast", "enhancement"], "h": {"id": "C0268250", "name": "C0268250#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0235946", "name": "C0235946#ent", "pos": [15, 16]}}
{"token": ["Interaction", "between", "intercellular", "adhesion", "molecule", "1", "ICAM-1", ")", "and", "lymphocyte", "function-associated", "antigen", "1", "C1334146#ent", "<e1>", ")", "might", "be", "involved", "in", "the", "pathogenesis", "of", "C0023895#ent", "<e2>"], "h": {"id": "C1334146", "name": "C1334146#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [23, 24]}}
{"token": ["Haloperidol-treated", "rats", "displayed", "a", "significant", "emergence", "of", "C0022614#ent", "<e1>", "stimulated", "oral", "activity", "nondirected", "oral", "movements", ",", "C0040822#ent", "<e2>", "audible", "teeth", "grinding", ",", "and", "directed", "oral", "movements", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040822", "name": "C0040822#ent", "pos": [16, 17]}}
{"token": ["The", "CBF", "was", "normal", "in", "C0409974#ent", "<e1>", "patients", "without", "cerebral", "disease", "also", "in", "C0752332#ent", "<e2>", "patients", "in", "remission", "."], "h": {"id": "C0409974", "name": "C0409974#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0752332", "name": "C0752332#ent", "pos": [13, 14]}}
{"token": ["Also", ",", "5", "out", "of", "6", "clones", "of", "stable", "fusion", "cells", "C3812805#ent", "<e1>", "and", "parent", "cells", "the", "parental", "type", "of", "responses", "to", "C0256103#ent", "<e2>", "and", "growth", "factors", "indicating", "that", "the", "C3812805#ent", "<e1>", "phenotype", "is", "recessive", "."], "h": {"id": "C3812805", "name": "C3812805#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [22, 23]}}
{"token": ["A", "10-year-old", "girl", "presented", "C0023212#ent", "<e1>", "month", "after", "the", "onset", "of", "hemolytic", "uremic", "syndrome", "C1538440#ent", "<e2>", ")", "caused", "by", "an", "Escherichia", "coli", "O157", "infection", "and", "was", "diagnosed", "as", "having", "dilated", "cardiomyopathy"], "h": {"id": "C0023212", "name": "C0023212#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [14, 15]}}
{"token": ["We", "report", "the", "case", "of", "a", "61-year-old", "man", "with", "nephrotic", "syndrome", "to", "C0156221#ent", "<e1>", "and", "chronic", "brucellosis", "by", "C0012736#ent", "<e2>"], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012736", "name": "C0012736#ent", "pos": [18, 19]}}
{"token": ["This", "either", "represents", "a", "variant", "of", "C0234166#ent", "<e1>", "with", "spasticity", "or", "suggests", "that", "genes", "for", "C0234166#ent", "<e1>", "and", "a", "form", "of", "C0037773#ent", "<e1>", "be", "closely", "linked", "."], "h": {"id": "C0234166", "name": "C0234166#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037773", "name": "C0037773#ent", "pos": [21, 22]}}
{"token": ["Genistein", ",", "a", "tyrosine", "kinase", "inhibitor", "significantly", "attenuated", "the", "ability", "of", "MgATP", "to", "stimulate", "C0388638#ent", "<e1>", "activity", "and", "accumulation", "of", "C1333677#ent", "<e2>", "the", "washed", "GTP[S]-treated", "cells", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333677", "name": "C1333677#ent", "pos": [20, 21]}}
{"token": ["were", "similar", "after", "decentralization", ",", "bilateral", "vagotomy", "or", "glossopharyngealotomy", ",", "and", "after", "autonomic", "blockers", "mecamylamine", ",", "C0004259#ent", "<e1>", ",", "mepyramine", ",", "and", "C0005324#ent", "<e2>", ")", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0005324", "name": "C0005324#ent", "pos": [22, 23]}}
{"token": ["Furthermore", ",", "the", "protein", "kinase", "C", "PKC", ")", "inhibitor", "calphostin", "C", "C1979930#ent", "<e1>", "MAP", ")", "kinase", "inhibitors", "PD98059", "and", "wortmannin", "also", "abolished", "the", "C3887648#ent", "<e2>", "effects", "on", "A", "and", "B", "cell", "."], "h": {"id": "C1979930", "name": "C1979930#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [23, 24]}}
{"token": ["Other", "C0003290#ent", "<e1>", "(", "such", "as", "rolipram", ")", "specifically", "inhibit", "C0081888#ent", "<e2>"], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0081888", "name": "C0081888#ent", "pos": [10, 11]}}
{"token": ["The", "pre-EP", "C1364818#ent", "<e1>", "group", "was", "compared", "with", "the", "post-EP", "C1364818#ent", "<e1>", "group", "and", "the", "pre-EP", "C1825590#ent", "<e1>", "group", "was", "compared", "with", "the", "post-EP", "C1825590#ent", "<e1>", "group", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1825590", "name": "C1825590#ent", "pos": [16, 17]}}
{"token": ["We", "have", "examined", "DNA", "repair", "the", "dihydrofolate", "reductase", "C0039667#ent", "<e1>", ")", "gene", "in", "cultured", "human", "cells", "treated", "with", "C0063172#ent", "<e2>", "(", "HMT", ")", "using", "a", "newly", "developed", "assay", "for", "interstrand", "DNA", "cross-linking", "in", "defined", "genomic", "sequences"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0063172", "name": "C0063172#ent", "pos": [18, 19]}}
{"token": ["We", "propose", "that", "this", "family", "of", "C1417679#ent", "<e1>", "be", "named", "C3540564#ent", "<e2>", ",", "for", "ribosomal", "S6", "kinase"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540564", "name": "C3540564#ent", "pos": [10, 11]}}
{"token": ["Induction", "was", "performed", "with", "droperidol", "(", "C0591413#ent", "<e1>", ")", "and", "etomidate", "(", "C0591624#ent", "<e2>", ")", ",", "maintenance", "with", "nitrous", "oxide/oxygen", "2:1", "and", "alfentanil", "."], "h": {"id": "C0591413", "name": "C0591413#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0591624", "name": "C0591624#ent", "pos": [12, 13]}}
{"token": ["Ovx", "did", "not", "affect", "C0032002#ent", "<e1>", "but", "subsequent", "treatment", "with", "C0086268#ent", "<e2>", "led", "to", "its", "more", "than", "two-fold", "increase", "(", "p<0.05", ")", "."], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086268", "name": "C0086268#ent", "pos": [10, 11]}}
{"token": ["To", "assess", "the", "prevalence", "of", "oesophagitis", ",", "C0004763#ent", "<e1>", "BE", ")", "and", "other", "oesophageal", "mucosal", "abnormalities", "patients", "with", "C1290138#ent", "<e2>", "SSc", ")", "without", "prior", "selection", "on", "digestive", "clinical", "presentation", "."], "h": {"id": "C0004763", "name": "C0004763#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [18, 19]}}
{"token": ["These", "results", "are", "consistent", "with", "extend", "previous", "observations", "suggesting", "that", "there", "are", "C1332691#ent", "<e1>", "differences", "in", "the", "regulation", "of", "C1537647#ent", "<e2>", "expression", "in", "ectopic", "and", "eutopic", "cells", "."], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1537647", "name": "C1537647#ent", "pos": [19, 20]}}
{"token": ["The", "C0270921#ent", "<e1>", "is", "followed", "by", "progressive", "neurodegeneration", "accompanied", "by", "C0087031#ent", "<e2>", "ataxia", "."], "h": {"id": "C0270921", "name": "C0270921#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0087031", "name": "C0087031#ent", "pos": [10, 11]}}
{"token": ["We", "found", "directional", "changes", "in", "allele", "frequency", "Pgi", "(", "11", "%", "increase", "in", "the", "Pgi-1", "C1706112#ent", "<e1>", ")", ",", "but", "not", "at", "C2697821#ent", "<e2>", "or", "Pgm", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2697821", "name": "C2697821#ent", "pos": [22, 23]}}
{"token": ["In", "a", "candidate", "gene", "approach", "identify", "new", "genes", "potentially", "involved", "in", "breast", "cancer", "susceptibility", ",", "we", "analyzed", "genomic", "variants", "the", "C1424471#ent", "<e1>", "a", "co-repressor", "implicated", "in", "BRCA1-mediated", "repression", "of", "C1333655#ent", "<e2>", "."], "h": {"id": "C1424471", "name": "C1424471#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1333655", "name": "C1333655#ent", "pos": [29, 30]}}
{"token": ["C0024727#ent", "<e1>", "was", "prepared", "from", "the", "C0017953#ent", "<e2>", "and", "from", "the", "yeast", "cell", "wall", "treatment", "of", "the", "fractions", "with", "hot", "solutions", "alkali", "."], "h": {"id": "C0024727", "name": "C0024727#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017953", "name": "C0017953#ent", "pos": [6, 7]}}
{"token": ["The", "ED50", "was", "13", "pM.", "C0076760#ent", "<e1>", "significantly", "inhibited", "the", "contractile", "effect", "C3470564#ent", "<e2>", "in", "gastric", "muscle", "cells"], "h": {"id": "C0076760", "name": "C0076760#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3470564", "name": "C3470564#ent", "pos": [12, 13]}}
{"token": ["TCDD", "activated", "C0812228#ent", "<e1>", ",", "ERK2", ",", "and", "increased", "the", "expression", "of", "C0059735#ent", "<e2>", ",", "PAI-2", ",", "IL-lb", "mRNA", ",", "and", "ERK2", "protein", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [12, 13]}}
{"token": ["This", "study", "was", "designed", "to", "characterize", "C1270169#ent", "<e1>", "lesions", "of", "11", "placentae", ",", "four", "VIV", "and", "seven", "C1848533#ent", "<e2>", ",", "ultrastructural", "descriptive", "comparisons", "of", "both", "types", "of", "C1270169#ent", "<e1>", "are", "discussed", "."], "h": {"id": "C1848533", "name": "C1848533#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1270169", "name": "C1270169#ent", "pos": [6, 7]}}
{"token": ["Two", "C0035541#ent", "<e1>", "(", "RNases", "K1", "and", "C1825741#ent", "<e2>", ")", "were", "purified", "from", "bovine", "kidney", "means", "of", "column", "chromatography", "phospho-cellulose", ",", "Sephadex", "G-50", ",", "CM-cellulose", ",", "heparin-Sepharose", ",", "nd", "agarose-APUP", "."], "h": {"id": "C0035541", "name": "C0035541#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1825741", "name": "C1825741#ent", "pos": [7, 8]}}
{"token": ["However", ",", "there", "is", "no", "report", "of", "RF-isotype", "or", "other", "rheumatoid", "arthritis", "C0002893#ent", "<e1>", ")", "autoantibody", "in", "C1424729#ent", "<e2>", "."], "h": {"id": "C0002893", "name": "C0002893#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1424729", "name": "C1424729#ent", "pos": [17, 18]}}
{"token": ["The", "affinity", "of", "C0038317#ent", "<e1>", "for", "the", "C3274833#ent", "<e2>", "was", "directly", "related", "to", "their", "known", "killing", "potency", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3274833", "name": "C3274833#ent", "pos": [7, 8]}}
{"token": ["However", ",", "the", "effect", "was", "greater", "in", "the", "forward", "direction", "and", "the", "C0991617#ent", "<e1>", "produced", "a", "statistically", "significant", "increase", "in", "ectodermal", "to", "endodermal", "C1422342#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1422342", "name": "C1422342#ent", "pos": [23, 24]}}
{"token": ["In", "addition", ",", "these", "C0991617#ent", "<e1>", "may", "modify", "C1422342#ent", "<e2>", "interfere", "with", "the", "adsorption", "at", "the", "surface", ",", "hence", "reducing", "calcium", "nodulation", "GATBP", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422342", "name": "C1422342#ent", "pos": [8, 9]}}
{"token": ["Genomes", "of", "the", "two", "herpesviruses", "occur", "frequently", "in", "severe", "adult", "periodontitis", ",", "localized", "and", "generalized", "juvenile", "periodontitis", "C0030360#ent", "<e1>", "periodontitis", ",", "Down's", "syndrome", "periodontitis", ",", "C0019686#ent", "<e2>", "acute", "necrotizing", "ulcerative", "gingivitis"], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0019686", "name": "C0019686#ent", "pos": [25, 26]}}
{"token": ["They", "were", "treated", "by", "intravenous", "fluid", "and", "drugs", "such", "as", "C0033497#ent", "<e1>", ",", "pizotiphene", ",", "diclophenac", ",", "granisetron", ",", "lorazepam", "and", "C0795650#ent", "<e2>", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0795650", "name": "C0795650#ent", "pos": [21, 22]}}
{"token": ["Among", "these", "four", "C1704943#ent", "<e1>", "genes", ",", "enhancement", "of", "the", "transcriptional", "induction", "of", "C1336624#ent", "<e2>", ",", "which", "prefers", "fatty", "acids", "substrates", ",", "was", "prominent", "in", "the", "mutant", "."], "h": {"id": "C1704943", "name": "C1704943#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336624", "name": "C1336624#ent", "pos": [13, 14]}}
{"token": ["Treatment", "of", "C3489929#ent", "<e1>", "low", "concentrations", "of", "C0960371#ent", "<e2>", "generates", "an", "enzyme", "fragment", "65", "kDa", "which", "is", "fully", "active", "in", "the", "absence", "of", "cGMP", "."], "h": {"id": "C3489929", "name": "C3489929#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [7, 8]}}
{"token": ["On", "the", "other", "hand", ",", "a", "combination", "of", "neonatal", "thymectomy", "C1563715#ent", "<e1>", "treatment", "enhanced", "both", "the", "size", "of", "the", "C0000833#ent", "<e2>", "the", "liver", "and", "the", "size", "of", "metastases", "to", "other", "sites", "."], "h": {"id": "C1563715", "name": "C1563715#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [19, 20]}}
{"token": ["We", "observed", "that", "the", "C0099085#ent", "<e1>", "showed", "fragmentation", "of", "the", "GA", "and", "the", "C1420709#ent", "<e2>", ",", "accompanied", "by", "a", "reduction", "in", "the", "number", "of", "fragmented", "Golgi", "elements", "and", "by", "a", "unique", "perinuclear", "distribution"], "h": {"id": "C0099085", "name": "C0099085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [13, 14]}}
{"token": ["Cardiovascular", "disease", "C0007820#ent", "<e1>", ")", "and", "osteoporosis", "(", "C0338271#ent", "<e2>", ")", "are", "public", "health", "problems", "numerous", "epidemiological", "links", "important", "economic", "consequences"], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [8, 9]}}
{"token": ["To", "investigate", "the", "exaggerated", "prolactin", "(", "PRL", ")", "responsiveness", "to", "C1421143#ent", "<e1>", "TRH", ")", "in", "patients", "with", "C0016034#ent", "<e2>", "BBD", ")", ",", "18", "patients", "and", "13", "healthy", "controls", "an", "8-week-long", "thyroid", "hormone", "treatment", "."], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0016034", "name": "C0016034#ent", "pos": [17, 18]}}
{"token": ["The", "gene", "product", "B.", "subtilis", "ffh", "shared", "53.9", "and", "32.6", "%", "C2917660#ent", "<e1>", "identity", "with", "E.", "coli", "C1809471#ent", "<e2>", "and", "the", "canine", "54-kDa", "subunit", "of", "signal", "recognition", "particle", "respectively", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1809471", "name": "C1809471#ent", "pos": [17, 18]}}
{"token": ["Recent", "in", "vitro", "in", "human", "colon", "cancer", "cells", "linked", "C1704341#ent", "<e1>", "enhancement", "of", "paclitaxel", ",", "doxorubicin", "and", "C0042671#ent", "<e2>", "cytotoxicity", "to", "inhibition", "of", "the", "P-glycoprotein", "(", "P-gp", ")", "pump", "."], "h": {"id": "C1704341", "name": "C1704341#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042671", "name": "C0042671#ent", "pos": [17, 18]}}
{"token": ["Even", "after", "C1705969#ent", "<e1>", "treatment", "from", "day", "0", ",", "pathologic", "findings", "C0024115#ent", "<e2>", "not", "improved", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "phenothiazine", "derivative", "chlorpromazine", "(", "C1413693#ent", "<e1>", ")", "and", "of", "the", "hallucinogen", "phencyclidine", "C1418873#ent", "<e2>", ")", "on", "ACh-activated", "single-channel", "properties", "were", "studied", "under", "conditions", "where", "both", "compounds", "are", "positively", "charged", "pH", "7.2", ")", "."], "h": {"id": "C1413693", "name": "C1413693#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418873", "name": "C1418873#ent", "pos": [15, 16]}}
{"token": ["The", "R(21)(TC", ")", "factor", ",", "obtained", "by", "transduction", "of", "the", "R(10)(TC.CM.SM.SA", ")", "factor", "with", "C0000608#ent", "<e1>", "group", "E", "C0036117#ent", "<e2>", ",", "is", "not", "transferable", "by", "the", "normal", "conjugal", "process", "."], "h": {"id": "C0000608", "name": "C0000608#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [18, 19]}}
{"token": ["Glutathione-S-transferases", ",", "NAD(P)H", ":", "quinone", "oxidoreductase1", "C0919428#ent", "<e1>", ")", "and", "NRH", ":", "C1136197#ent", "<e2>", "NQO2", ")", "provide", "important", "cellular", "defences", "the", "neurotoxicity", "induced", "by", "catecholamine-derived", "o-quinones", "and", "oxidative", "stress", "redox", "cycling"], "h": {"id": "C0919428", "name": "C0919428#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [12, 13]}}
{"token": ["In", "cultured", "primary", "human", "renal", "mesangial", "cells", "HMC", ")", ",", "the", "C3273756#ent", "<e1>", "medium-induced", "upregulation", "of", "VEGF", "and", "C1705079#ent", "<e2>", "was", "largely", "blocked", "by", "PEDF", "."], "h": {"id": "C3273756", "name": "C3273756#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705079", "name": "C1705079#ent", "pos": [18, 19]}}
{"token": ["Our", "objective", "was", "to", "compare", "the", "predictive", "value", "C1705964#ent", "<e1>", "treatment", "outcome", "patients", "with", "generalized", "anxiety", "disorder", "GAD", ")", "treated", "with", "C4048284#ent", "<e2>", ",", "serotonin", "receptor", "5HT-1A", ")", "partial", "agonists", ",", "or", "placebo", "."], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [21, 22]}}
{"token": ["The", "genome", "of", "Methanothermobacter", "thermautotrophicus", "as", "a", "hitherto", "unique", "case", ",", "is", "apparently", "devoid", "of", "genes", "coding", "for", "C0077845#ent", "<e1>", "the", "universal", "C0127400#ent", "<e2>", "of", "base", "excision", "repair", "hydrolytic", "deamination", "of", "DNA", "cytosine", "residues", "."], "h": {"id": "C0077845", "name": "C0077845#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [22, 23]}}
{"token": ["The", "severity", "of", "C0948480#ent", "<e1>", "significantly", "lower", "in", "C1418543#ent", "<e2>", "compared", "to", "Re+", "and", "Re-", "(", "both", "p", "<", "0.01", ")", ",", "but", "no", "difference", "was", "observed", "between", "Re+", "and", "Re-", "."], "h": {"id": "C0948480", "name": "C0948480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418543", "name": "C1418543#ent", "pos": [8, 9]}}
{"token": ["We", "conclude", "that", "the", "P-448", "and", "not", "the", "C0022173#ent", "<e1>", "cytochrome", "P-450", "an", "obligatory", "role", "in", "the", "inhibition", "of", "C1421374#ent", "<e2>", "by", "halogenated", "biphenyls"], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421374", "name": "C1421374#ent", "pos": [19, 20]}}
{"token": ["Recent", "studies", "have", "shown", "that", "the", "interaction", "of", "various", "C0040615#ent", "<e1>", "antidepressants", "with", "isolated", "C1418186#ent", "<e2>", "at", "one", "common", "binding", "site", "with", "relatively", "high", "association", "constants", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418186", "name": "C1418186#ent", "pos": [14, 15]}}
{"token": ["C0024959#ent", "<e1>", "be", "diagnosed", "incorrectly", "as", "TMJ", "C0039496#ent", "<e2>", "of", "a", "similarity", "of", "signs", "and", "symptoms", "."], "h": {"id": "C0024959", "name": "C0024959#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039496", "name": "C0039496#ent", "pos": [7, 8]}}
{"token": ["Both", "the", "arginine", "analog", "NG-monomethyl-L-arginine", "C1412515#ent", "<e1>", ",", "which", "breaks", "down", "arginine", "decreased", "macrophage", "C0002444#ent", "<e2>", "activity", "."], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002444", "name": "C0002444#ent", "pos": [14, 15]}}
{"token": ["A", "sequence", "of", "18", "guanosine", "residues", ",", "which", "can", "impede", "a", "3'-->5", "'", "C0015301#ent", "<e1>", "in", "vitro", "is", "able", "to", "substitute", "for", "the", "C3541299#ent", "<e2>", "in", "vivo"], "h": {"id": "C0015301", "name": "C0015301#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3541299", "name": "C3541299#ent", "pos": [23, 24]}}
{"token": ["C0812385#ent", "<e1>", "a", "major", "allergen", "of", "timothy", "grass", "causes", "C0009443#ent", "<e2>", "and", "bronchial", "asthma", "nearly", "all", "patients", "allergic", "to", "grass", "pollen"], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "the", "human", "C1418965#ent", "<e1>", "encoded", "in", "a", "region", "near", "the", "class", "I", "major", "histocompatibility", "complex", "C0024518#ent", "<e2>", ")", "that", "has", "been", "linked", "to", "type", "1", "diabetes", "mellitus", "susceptibility", "."], "h": {"id": "C1418965", "name": "C1418965#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [17, 18]}}
{"token": ["Abrogation", "of", "p21", "or", "pRB", "function", "in", "cells", "containing", "C2987364#ent", "<e1>", "p53", "blocked", "the", "down-regulation", "of", "cyclin", "B1", "C1418727#ent", "<e2>", "expression", "and", "led", "to", "an", "accelerated", "exit", "from", "G(2", ")", "after", "genotoxic", "stress"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418727", "name": "C1418727#ent", "pos": [18, 19]}}
{"token": ["Concomitant", "with", "G(2)/M", "cell", "accumulation", ",", "treatment", "of", "C2987364#ent", "<e1>", "MEFs", "with", "TGF-beta3", "also", "resulted", "in", "down-regulation", "of", "both", "C1418727#ent", "<e2>", "and", "Plk", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418727", "name": "C1418727#ent", "pos": [19, 20]}}
{"token": ["We", "concluded", "that", "A.", "marginale", "was", "the", "major", "cause", "of", "the", "C1387532#ent", "<e1>", "while", "coinfections", "with", "other", "C0035064#ent", "<e2>", "exacerbated", "the", "disease", "."], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}}
{"token": ["Mastoparan", "stimulated", "increases", "in", "phosphatidic", "acid", "PA", ")", "and", "diacylglycerol", "pyrophosphate", "indicative", "of", "PLD", "or", "PLC", "activity", "in", "combination", "with", "C0113519#ent", "<e1>", "DGK", ")", "and", "C0211705#ent", "<e2>"], "h": {"id": "C0113519", "name": "C0113519#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [25, 26]}}
{"token": ["These", "artificial", "electron", "donors", "did", "not", "require", "phospholipid", "for", "oxidation", "reactions", "however", ",", "phospholipid", "was", "required", "for", "optimal", "activity", "when", "either", "C1620185#ent", "<e1>", "the", "truncated", "form", "used", "with", "C0027310#ent", "<e2>"], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0027310", "name": "C0027310#ent", "pos": [28, 29]}}
{"token": ["This", "survey", "provides", "new", "information", "on", "the", "severity", "of", "factor", "IX", "deficiencies", "among", "patients", "being", "treated", "for", "C0684275#ent", "<e1>", "on", "the", "prevalence", "of", "C3669283#ent", "<e2>", "this", "population", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3669283", "name": "C3669283#ent", "pos": [23, 24]}}
{"token": ["The", "human", "homologue", "of", "the", "C1333314#ent", "<e1>", "PTCH", ")", "has", "been", "identified", "as", "the", "C0079429#ent", "<e2>", "for", "the", "naevoid", "basal", "cell", "carcinoma", "BCC", ")", "syndrome", "and", "has", "also", "been", "shown", "to", "be", "mutated", "in", "sporadic", "BCC"], "h": {"id": "C1333314", "name": "C1333314#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}}
{"token": ["The", "beta", "2-agonists", "zinterol", "and", "procaterol", "also", "stimulated", "glycogenolysis", "in", "C0669372#ent", "<e1>", "and", "their", "effects", "were", "inhibited", "by", "propranolol", "and", "C3811063#ent", "<e2>", "339", ",", "but", "not", "by", "practolol", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3811063", "name": "C3811063#ent", "pos": [20, 21]}}
{"token": ["On", "one", "hand", "it", "can", "mimic", "C1692886#ent", "<e1>", "on", "the", "other", "hand", "it", "may", "progress", "into", "C1882414#ent", "<e2>"], "h": {"id": "C1692886", "name": "C1692886#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1882414", "name": "C1882414#ent", "pos": [16, 17]}}
{"token": ["Herbimycin", "A", "C0906802#ent", "<e1>", "differentiated", "K562", "cells", "with", "the", "transient", "down-regulated", "C1705791#ent", "<e2>", "."], "h": {"id": "C0906802", "name": "C0906802#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [11, 12]}}
{"token": ["Monkey", "PBMCs", "stimulated", "with", "imiquimod", ",", "C0381150#ent", "<e1>", "and", "S-28463", "showed", "increased", "mRNA", "levels", "of", "C1415900#ent", "<e2>", ",", "IL-1alpha", ",", "IL-6", "and", "the", "IFN", "inducible", "protein", "MxA", "above", "those", "seen", "in", "untreated", "cultures"], "h": {"id": "C0381150", "name": "C0381150#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415900", "name": "C1415900#ent", "pos": [15, 16]}}
{"token": ["To", "compare", "the", "endocrine", "effects", "of", "dopamine", "and", "C0700450#ent", "<e1>", "in", "hypotensive", "very", "low", "birthweight", "C0282666#ent", "<e2>", ")", "infants", "."], "h": {"id": "C0700450", "name": "C0700450#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282666", "name": "C0282666#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "all", "measured", "inflammation", "markers", "were", "significantly", "greater", "in", "patients", "with", "C1449563#ent", "<e1>", "than", "in", "controls", "and", "were", "negatively", "correlated", "with", "C3711381#ent", "<e2>", "."], "h": {"id": "C1449563", "name": "C1449563#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3711381", "name": "C3711381#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "extracts", "of", "L.", "indica", "almost", "totally", "inhibited", "nitric", "oxide", "production", "and", "the", "mRNA", "expression", "of", "C1533698#ent", "<e1>", "at", "a", "dosage", "of", "100", "microg/mL", ",", "in", "C3273299#ent", "<e2>"], "h": {"id": "C1533698", "name": "C1533698#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3273299", "name": "C3273299#ent", "pos": [27, 28]}}
{"token": ["Our", "results", "also", "suggest", "that", "C0017789#ent", "<e1>", "release", "caused", "by", "C1412332#ent", "<e2>", "is", "designed", "to", "promote", "neuronal", "survival"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [10, 11]}}
{"token": ["The", "C0003289#ent", "<e1>", "effects", "could", "be", "antagonized", "by", "C0011812#ent", "<e2>", ",", "desmethylimipramine", ",", "dibutyryl", "cyclic", "3'5'-adenosine", "monophosphate", "and", "caffeine.3", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011812", "name": "C0011812#ent", "pos": [8, 9]}}
{"token": ["These", "studies", "demonstrate", "that", "C1335631#ent", "<e1>", "acid-induced", "stress", "fiber", "formation", ",", "which", "is", "required", "for", "C1420234#ent", "<e2>", "exocytosis", ",", "and", "increases", "in", "C1420234#ent", "<e2>", "activity", "."], "h": {"id": "C1335631", "name": "C1335631#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420234", "name": "C1420234#ent", "pos": [15, 16]}}
{"token": ["Verapamil", "increased", "the", "expression", "of", "C0796516#ent", "<e1>", "pi", "mRNA", "in", "P388/ADR", "C0085752#ent", "<e2>", "resistant", "lines", "."], "h": {"id": "C0796516", "name": "C0796516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [11, 12]}}
{"token": ["The", "aac2(A128P", ")", "C1706112#ent", "<e1>", "dominantly", "induces", "ageing-dependent", "C1563761#ent", "<e2>", "phenotypically", "tractable", "degenerative", "cell", "death", "independently", "of", "its", "ADP/ATP", "exchange", "activity"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1563761", "name": "C1563761#ent", "pos": [8, 9]}}
{"token": ["Even", "though", "there", "are", "indications", "of", "association", "with", "specific", "C0699949#ent", "<e1>", "there", "is", "still", "no", "final", "proof", "that", "C1825592#ent", "<e2>", "plays", "a", "truly", "causative", "pathogenic", "role", "."], "h": {"id": "C0699949", "name": "C0699949#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1825592", "name": "C1825592#ent", "pos": [18, 19]}}
{"token": ["The", "ability", "of", "VEGF", "to", "be", "chemotactic", "for", "monocytes", "and", "to", "increase", "the", "activity", "of", "C0162745#ent", "<e1>", "and", "plasminogen", "activator", "have", "implications", "for", "renal", "development", "C0035086#ent", "<e2>"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [25, 26]}}
{"token": ["Substitution", "of", "the", "more", "basic", "residues", "resulted", "in", "enhanced", "thermal", "stability", "decreased", "rate", "of", "C1414292#ent", "<e1>", "and", "decreased", "susceptibility", "to", "controlled", "proteolysis", "relative", "to", "C2987364#ent", "<e2>", "actin", "."], "h": {"id": "C1414292", "name": "C1414292#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [24, 25]}}
{"token": ["A", "new", "method", "based", "on", "the", "delipidation", "with", "C0014994#ent", "<e1>", "and", "deproteinization", "with", "C0272170#ent", "<e2>", "of", "previously", "isolated", "melanosomes", "is", "proposed", "."], "h": {"id": "C0014994", "name": "C0014994#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [13, 14]}}
{"token": ["The", "findings", "of", "the", "study", "indicate", "that", "C0054207#ent", "<e1>", "improved", "the", "symptoms", "of", "C0011269#ent", "<e2>", "the", "most", "improvement", "was", "recorded", "in", "patients", "who", "had", "received", "C0054207#ent", "<e1>", "for", "the", "longest", "period", "."], "h": {"id": "C0054207", "name": "C0054207#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011269", "name": "C0011269#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "we", "cloned", "the", "frog", "and", "C3274826#ent", "<e1>", "C2697654#ent", "<e2>", "homologues", "and", "the", "mouse", "C2697654#ent", "<e2>", "paralogue", ",", "and", "characterized", "their", "enzymatic", "properties", "using", "recombinants", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2697654", "name": "C2697654#ent", "pos": [11, 12]}}
{"token": ["We", "report", "here", "that", "in", "RBL-2H3", "cells", ",", "C1708630#ent", "<e1>", "and", "C0080059#ent", "<e2>", "are", "activated", "after", "Fc", "epsilon", "RI", "crosslinking", "and", "C1708630#ent", "<e1>", "coimmunoprecipitates", "with", "Fc", "epsilon", "RI"], "h": {"id": "C0080059", "name": "C0080059#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1708630", "name": "C1708630#ent", "pos": [8, 9]}}
{"token": ["The", "localization", "of", "cell", "surface", "MMTV", "C0072522#ent", "<e1>", "appeared", "normal", "in", "a", "transcriptional", "variant", "C1413694#ent", "<e2>", ")", "that", "produces", "basal", "levels", "MMTV", "RNA", "and", "glycoprotein", "precursors", "in", "the", "presence", "of", "dexamethasone", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413694", "name": "C1413694#ent", "pos": [14, 15]}}
{"token": ["There", "is", "no", "evidence", "that", "C0009002#ent", "<e1>", "enhances", "C0947622#ent", "<e2>", "formation", "and", "severely", "impairs", "liver", "function", "but", "C0009002#ent", "<e1>", "may", "increase", "the", "incidence", "of", "renal", "stones"], "h": {"id": "C0947622", "name": "C0947622#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [5, 6]}}
{"token": ["We", "report", "a", "case", "of", "C0393570#ent", "<e1>", "CBD", ")", "presenting", "with", "C0233763#ent", "<e2>"], "h": {"id": "C0393570", "name": "C0393570#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0233763", "name": "C0233763#ent", "pos": [11, 12]}}
{"token": ["C3813556#ent", "<e1>", "is", "more", "sensitive", "than", "radiographs", "and", "radionuclide", "scans", "detecting", "C0524799#ent", "<e2>", "in", "showing", "their", "distribution", "."], "h": {"id": "C3813556", "name": "C3813556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524799", "name": "C0524799#ent", "pos": [11, 12]}}
{"token": ["A", "theory", "of", "a", "possible", "etiologic", "basis", "for", "the", "development", "of", "C0242770#ent", "<e1>", "in", "patients", "with", "C0009782#ent", "<e2>", "discussed", "."], "h": {"id": "C0242770", "name": "C0242770#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [16, 17]}}
{"token": ["Although", "C0242770#ent", "<e1>", "has", "been", "associated", "with", "C0009782#ent", "<e2>", "there", "are", "rare", "reports", "of", "C0242770#ent", "<e1>", "in", "patients", "with", "systemic", "lupus", "erythematosus", "SLE", ")", "."], "h": {"id": "C0242770", "name": "C0242770#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [7, 8]}}
{"token": ["Anaplasmosis", ",", "a", "C0014761#ent", "<e1>", "cattle", "caused", "by", "the", "C0162700#ent", "<e2>", "Anaplasma", "marginale", "Rickettsiales", ":", "Anaplasmataceae", ")", "has", "been", "controlled", "using", "killed", "vaccines", "made", "with", "antigen", "harvested", "from", "infected", "bovine", "erythrocytes", "."], "h": {"id": "C0014761", "name": "C0014761#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162700", "name": "C0162700#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "Smad3", "interacts", "with", "C0216876#ent", "<e1>", ",", "which", "requires", "its", "MADS", "domain", "and", "disrupts", "its", "association", "with", "the", "C0282625#ent", "<e2>", "GRIP-1", ",", "thus", "diminishing", "the", "transcription", "activity", "C0216876#ent", "<e1>", "."], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0216876", "name": "C0216876#ent", "pos": [6, 7]}}
{"token": ["The", "results", "suggest", "that", "noradrenaline", "release", "in", "the", "mouse", "C0001614#ent", "<e1>", "inhibited", "by", "histamine", "via", "H3A", "receptors", "and", "that", "C0058185#ent", "<e2>", "is", "an", "H3", "receptor", "antagonist", "moderate", "potency", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0058185", "name": "C0058185#ent", "pos": [19, 20]}}
{"token": ["Expression", "of", "the", "genes", "encoding", "the", "beta/A4", "amyloid", "protein", "precursor", "APP", ")", "and", "C1446659#ent", "<e1>", "studied", "in", "an", "embryonal", "carcinoma", "cell", "line", "C1413292#ent", "<e2>", ")", "that", "differentiates", "in", "vitro", "cholinergic", "neurons", "after", "treatment", "with", "retinoic", "acid"], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413292", "name": "C1413292#ent", "pos": [22, 23]}}
{"token": ["Hemin", "and", "C1415619#ent", "<e1>", "reversed", "IL-18-mediated", "p38alpha", "induction", "and", "restored", "C1366875#ent", "<e2>"], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366875", "name": "C1366875#ent", "pos": [10, 11]}}
{"token": ["The", "highest", "titers", "of", "antibody", "to", "C1425409#ent", "<e1>", "were", "found", "in", "patients", "having", "a", "mixed", "C0026272#ent", "<e2>", "features", "of", "SLE", ",", "scleroderma", ",", "and", "myositis", "."], "h": {"id": "C1425409", "name": "C1425409#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026272", "name": "C0026272#ent", "pos": [15, 16]}}
{"token": ["Six", "centers", "participated", "in", "a", "double-blind", "crossover", "study", "patients", "with", "C0003873#ent", "<e1>", "RA", ")", "and", "C0029408#ent", "<e2>", "to", "evaluate", "the", "most", "advantageous", "timing", "of", "the", "daily", "dose", "benoxaprofen", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [15, 16]}}
{"token": ["Pseudo-equilibrium", "studies", "at", "37", "degrees", "C", "for", "2", "h", "have", "shown", "that", "this", "binding", "site", "C0051874#ent", "<e1>", "a", "high", "affinity", "(", "C1839259#ent", "<e2>", "=", "0.24", "+", "/-", "0.03", "nM", ")", "."], "h": {"id": "C0051874", "name": "C0051874#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [21, 22]}}
{"token": ["Degradation", "of", "C1826396#ent", "<e1>", "(", "NF", ")", "proteins", "by", "Ca2", "+", "-activated", "neutral", "protease", "C1413114#ent", "<e2>", ")", "was", "studied", "in", "the", "nervous", "system", "rats", "treated", "with", "neurotoxic", "or", "non-neurotoxic", "compounds", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413114", "name": "C1413114#ent", "pos": [14, 15]}}
{"token": ["The", "finding", "of", "easily", "demonstrable", ",", "intragenic", "variants", "will", "be", "beneficial", "to", "the", "study", "of", "the", "role", "of", "the", "C0038296#ent", "<e1>", "and", "the", "adjacent", "aldosterone", "synthase", "CYP11B2", ")", "gene", "in", "C0848548#ent", "<e2>"], "h": {"id": "C0038296", "name": "C0038296#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0848548", "name": "C0848548#ent", "pos": [30, 31]}}
{"token": ["These", "results", "show", "that", "the", "35-kD", "antigen", "and", "HSP1", "from", "C0004238#ent", "<e1>", "downregulate", "IgE", "in", "vitro", "are", "capable", "of", "inducing", "eosinophilia", "in", "C0004031#ent", "<e2>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004031", "name": "C0004031#ent", "pos": [22, 23]}}
{"token": ["We", "report", "a", "case", "of", "cycloserine-induced", "Stevens-Johnson", "syndrome", "C2987154#ent", "<e1>", ")", "in", "a", "38-year-old", "male", "with", "the", "acquired", "C0001175#ent", "<e2>", "AIDS", ")", "and", "multidrug", "resistant", "tuberculosis", "MDR-TB", ")", "."], "h": {"id": "C2987154", "name": "C2987154#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [18, 19]}}
{"token": ["These", "indices", "include", "the", "log", "fitness", "ratio", "LFR", ")", ",", "the", "log", "relative", "fitness", "(", "C1538143#ent", "<e1>", ")", ",", "and", "the", "production", "rate", "ratio", "C1425435#ent", "<e2>", ")", "."], "h": {"id": "C1538143", "name": "C1538143#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1425435", "name": "C1425435#ent", "pos": [24, 25]}}
{"token": ["Anaesthetization", "with", "tricaine", "clearly", "influenced", "all", "blood", "values", ",", "except", "plasma", "enzyme", "activities", "(", "C1412073#ent", "<e1>", ",", "ALAT", "and", "C1456795#ent", "<e2>", ")", "."], "h": {"id": "C1412073", "name": "C1412073#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "report", "that", "C1415470#ent", "<e1>", "interacts", "with", "C1416692#ent", "<e2>", "a", "subunit", "of", "the", "kinesin", "motor", "complex", "drives", "anterograde", "transport", "microtubules", "in", "neuronal", "processes"], "h": {"id": "C1415470", "name": "C1415470#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416692", "name": "C1416692#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "report", "that", "phosphorylation", "of", "C1415470#ent", "<e1>", "decreases", "its", "association", "with", "microtubule-dependent", "transport", "proteins", "dynactin", "p150", "and", "C1416692#ent", "<e2>", "reduces", "its", "localization", "in", "neurite", "tips"], "h": {"id": "C1415470", "name": "C1415470#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416692", "name": "C1416692#ent", "pos": [18, 19]}}
{"token": ["A", "comparison", "of", "C1413299#ent", "<e1>", "intragenic", "haplotypes", "showed", "that", "SNPs", "exclusive", "to", "C1422073#ent", "<e2>", "located", "in", "regions", "implicated", "in", "the", "stabilization", "of", "RNA", "transcripts", "."], "h": {"id": "C1413299", "name": "C1413299#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422073", "name": "C1422073#ent", "pos": [12, 13]}}
{"token": ["Both", "GST", "pull-down", "experiments", "and", "direct", "binding", "assays", "in", "vitro", "that", "C1428950#ent", "<e1>", "interacts", "selectively", "with", "the", "C2987364#ent", "<e2>", "and", "GTP-restricted", "but", "not", "GDP-restricted", "form", "of", "Rab34", "."], "h": {"id": "C1428950", "name": "C1428950#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [17, 18]}}
{"token": ["Ultrastructural", "study", "leukocytes", "confirmed", "DCS", "in", "a", "child", "homozygous", "for", "a", "novel", "ABHD5", "mutation", ",", "with", "C0020757#ent", "<e1>", ",", "developmental", "delay", "and", "steatohepatitis", "with", "C1623038#ent", "<e2>", ",", "manifest", "only", "as", "elevated", "aminotranferase", "levels", "."], "h": {"id": "C0020757", "name": "C0020757#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [24, 25]}}
{"token": ["We", "have", "cloned", "the", "murine", "C1427015#ent", "<e1>", "cDNA", "and", "compared", "its", "expression", "pattern", "to", "that", "of", "C4255258#ent", "<e2>", "from", "embryonic", "day", "E", ")", "E7-E11.5", "using", "in", "situ", "hybridization"], "h": {"id": "C1427015", "name": "C1427015#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4255258", "name": "C4255258#ent", "pos": [16, 17]}}
{"token": ["Among", "them", ",", "most", "up-regulated", "C0017337#ent", "<e1>", ",", "such", "as", "C1412493#ent", "<e2>", "and", "Claudin-4", ",", "were", "expressed", "in", "both", "adenocarcinoma", "cells", "type", "II", "alveolar", "pneumocytes", "corresponding", "to", "the", "histological", "similarity", "between", "these", "cell", "types"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412493", "name": "C1412493#ent", "pos": [10, 11]}}
{"token": ["PAH", "<", "C0033209#ent", "<e1>", "<", "apalcillin", "inhibited", "C1442521#ent", "<e2>", "excretion", "in", "the", "urine", "and", ",", "to", "a", "similar", "degree", ",", "C1442521#ent", "<e2>", "fluorescence", "in", "cortical", "tissue"], "h": {"id": "C0033209", "name": "C0033209#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [7, 8]}}
{"token": ["The", "studied", "TSGs", "comprised", "FHIT", ",", "VHL", ",", "APC", ",", "C1709395#ent", "<e1>", ",", "p16", ",", "IFNA", ",", "PTEN", ",", "C1366618#ent", "<e2>", ",", "ATM", ",", "p53", ",", "BRCA1", ",", "DPC4", "and", "DCC", "."], "h": {"id": "C1709395", "name": "C1709395#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366618", "name": "C1366618#ent", "pos": [19, 20]}}
{"token": ["Zaltoprofen", ",", "which", "is", "a", "C3536840#ent", "<e1>", "prevented", "the", "C0524928#ent", "<e2>", "tetrachloride-induced", "body", "weight", "decrease", ",", "without", "preventing", "the", "C0524928#ent", "<e2>", "tetrachloride-induced", "loss", "of", "food", "intake"], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [9, 10]}}
{"token": ["src", "stimulation", "of", "transcription", "from", "this", "region", "was", "inhibited", "by", "co-transfection", "with", "a", "dominant-negative", "mutant", "Ets-2", ",", "demonstrating", "that", "the", "effects", "of", "src", "kinase", "C3543839#ent", "<e1>", "expression", "are", "dependent", "on", "C0812380#ent", "<e2>", "."], "h": {"id": "C3543839", "name": "C3543839#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0812380", "name": "C0812380#ent", "pos": [30, 31]}}
{"token": ["Here", "we", "found", "that", "spinal", "cord", "injured", ",", "wild-type", "mice", "expressing", "C3494976#ent", "<e1>", "developed", "a", "more", "severe", "glial", "scar", "enhanced", "expression", "of", "C1413763#ent", "<e2>", "indicative", "of", "a", "more", "inhibitory", "environment", "for", "axonal", "regeneration/plasticity", "than", "MMP-9", "null", "mice"], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413763", "name": "C1413763#ent", "pos": [22, 23]}}
{"token": ["Glutathione", "peroxidase", "GSH-Px", ")", ",", "hydroxyacyl", "coenzyme-A", "dehydrogenase", "C0022917#ent", "<e1>", "were", "higher", "in", "HF-GH1", "than", "in", "C1313497#ent", "<e2>", "."], "h": {"id": "C0022917", "name": "C0022917#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1313497", "name": "C1313497#ent", "pos": [16, 17]}}
{"token": ["The", "resistance", "of", "the", "obtained", "C0017953#ent", "<e1>", "towards", "proteolytic", "hydrolysis", "rat", "serum", "and", "by", "five", "C0030940#ent", "<e2>", "was", "compared", "with", "that", "of", "original", "peptide", "."], "h": {"id": "C0017953", "name": "C0017953#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [15, 16]}}
{"token": ["EcoR124I", "is", "a", "multicomplex", "C0014442#ent", "<e1>", "belonging", "to", "the", "C0012910#ent", "<e2>", "Escherichia", "coli"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012910", "name": "C0012910#ent", "pos": [9, 10]}}
{"token": ["REBASE", "is", "a", "comprehensive", "database", "information", "about", "restriction", "C0014442#ent", "<e1>", ",", "DNA", "methyltransferases", "related", "proteins", "involved", "in", "C0012910#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012910", "name": "C0012910#ent", "pos": [17, 18]}}
{"token": ["The", "subjects", "were", "given", "two", "tablets", "of", "placebo", ",", "verapamil", "(", "80", "mg", ")", ",", "C0028066#ent", "<e1>", "(", "20", "mg", ")", "or", "C0012373#ent", "<e2>", "(", "60", "mg", ")", "orally", "and", "double-blindly", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0012373", "name": "C0012373#ent", "pos": [22, 23]}}
{"token": ["Cultured", "smooth", "muscle", "cells", "from", "the", "rabbit", "aorta", "exhibit", "a", "significant", "des-Arg9-BK-induced", "increase", "in", "[3H]-thymidine", "incorporation", "if", "pretreated", "with", "a", "C0085387#ent", "<e1>", "diclofenac", ")", "and", "concomitantly", "treated", "with", "cytokines", "IL-1", "or", "C3887694#ent", "<e2>", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3887694", "name": "C3887694#ent", "pos": [31, 32]}}
{"token": ["These", "indices", "increased", "after", "C0014026#ent", "<e1>", "but", "were", "not", "modified", "after", "C0033497#ent", "<e2>", "."], "h": {"id": "C0014026", "name": "C0014026#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [11, 12]}}
{"token": ["However", ",", "hepatic", "NEMO", "deficiency", "with", "HFD", "in", "the", "development", "of", "C2711227#ent", "<e1>", "a", "consequence", "of", "decreased", "peroxisome", "proliferator-activated", "receptor", "PPAR-alpha", ")", "and", "increased", "C1418779#ent", "<e2>", "expression", "."], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [24, 25]}}
{"token": ["Immunocytochemical", "studies", "with", "antibodies", "generated", "against", "the", "purified", "C0027203#ent", "<e1>", "and", "to", "a", "synthetic", "peptide", "that", "C1425030#ent", "<e2>", "was", "localized", "to", "the", "ECM", "of", "tentacles", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425030", "name": "C1425030#ent", "pos": [16, 17]}}
{"token": ["As", "an", "C3853872#ent", "<e1>", "set", "to", "pH", "4", ")", "C0036088#ent", "<e2>", "0.9", "%", "NaCl", "solution", "were", "used", "."], "h": {"id": "C3853872", "name": "C3853872#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036088", "name": "C0036088#ent", "pos": [9, 10]}}
{"token": ["We", "also", "tested", "the", "gastric", "effects", "C0058678#ent", "<e1>", "well", "as", "a", "putative", "antagonist", "of", "neuroexcitant", "amino", "acid", "receptors", "C0022816#ent", "<e2>"], "h": {"id": "C0058678", "name": "C0058678#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022816", "name": "C0022816#ent", "pos": [18, 19]}}
{"token": ["Signaling", "between", "MyD88", "and", "C1336666#ent", "<e1>", "is", "mediated", "by", "members", "of", "the", "C0387030#ent", "<e2>", "IRAK", ")", "family", ";", "however", ",", "the", "exact", "function", "of", "each", "IRAK", "protein", "controversial", "."], "h": {"id": "C1336666", "name": "C1336666#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0387030", "name": "C0387030#ent", "pos": [12, 13]}}
{"token": ["Signal", "transduction", "MyD88", "and", "C1336666#ent", "<e1>", "is", "known", "to", "involve", "the", "C0387030#ent", "<e2>", "IRAK-1", ")", "and", "two", "homologous", "proteins", "IRAK-2", "(", "ref", "."], "h": {"id": "C1336666", "name": "C1336666#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0387030", "name": "C0387030#ent", "pos": [11, 12]}}
{"token": ["A", "major", "portion", "of", "the", "deduced", "amino", "acid", "sequence", "been", "verified", "by", "C0030956#ent", "<e1>", "mapping", "and", "sequencing", "of", "the", "C0012892#ent", "<e2>"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [19, 20]}}
{"token": ["CAT", "was", "overproduced", "to", "various", "levels", "in", "the", "presence", "and", "absence", "of", "GroEL", "C0221406#ent", "<e1>", ",", "and", "in", "C1415782#ent", "<e2>", "mutants", "."], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415782", "name": "C1415782#ent", "pos": [18, 19]}}
{"token": ["C0221406#ent", "<e1>", "of", "TF", "enhanced", "the", "capacity", "of", "C1415782#ent", "<e2>", "to", "bind", "to", "many", "denatured", "proteins"], "h": {"id": "C0221406", "name": "C0221406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415782", "name": "C1415782#ent", "pos": [8, 9]}}
{"token": ["Levels", "of", "thyrotropin-releasing", "hormone", "C1705225#ent", "<e1>", ")", ",", "C1705225#ent", "<e1>", "mRNA", "and", "C0034311#ent", "<e1>", "analyzed", "in", "the", "hypothalamus-adenohypophyseal", "axis", "lactation", "and", "estrous", "cycle"], "h": {"id": "C1705225", "name": "C1705225#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034311", "name": "C0034311#ent", "pos": [12, 13]}}
{"token": ["To", "investigate", "the", "pathogenesis", "of", "immunological", "abnormalities", "IA", ")", "in", "myelodysplastic", "syndrome", "C3273937#ent", "<e1>", ")", ",", "we", "examined", "B", "cells", "their", "ability", "to", "produce", "C1333196#ent", "<e2>", "and", "their", "X", "chromosome", "inactivation", "pattern", "XCIP", ")", "."], "h": {"id": "C3273937", "name": "C3273937#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [24, 25]}}
{"token": ["C0007965#ent", "<e1>", "828", "is", "a", "new", "C4055261#ent", "<e2>", "a", "pyridyl", "cyanoguanidine"], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4055261", "name": "C4055261#ent", "pos": [6, 7]}}
{"token": ["The", "Pneumocystis", "carinii", "pneumonia", "often", "shows", "a", "rapid", "and", "severe", "course", ",", "and", "type", "I", "allergy", "the", "parasite", "might", "be", "a", "pathogenic", "C0003438#ent", "<e1>", "in", "the", "C3714636#ent", "<e2>"], "h": {"id": "C0003438", "name": "C0003438#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [26, 27]}}
{"token": ["C0360714#ent", "<e1>", "activate", "phosphatidylinositol-3-kinase", ",", "which", "activates", "ecto-5'-nucleotidase", "and", "C1335204#ent", "<e2>", "PDK-1", ")", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335204", "name": "C1335204#ent", "pos": [9, 10]}}
{"token": ["Delta", "coinfection", "not", "show", "greater", "severity", ",", "as", "evaluated", "by", "the", "levels", "of", "C1420113#ent", "<e1>", ",", "ALT", ",", "total", "bilirubin", "prothrombin", "activity", "than", "hepatitis", "B", "C0275524#ent", "<e2>", "."], "h": {"id": "C1420113", "name": "C1420113#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [25, 26]}}
{"token": ["Genetic", "modification", "peripheral", "blood", "T", "lymphocytes", "been", "proposed", "as", "a", "therapeutic", "strategy", "treating", "C0242354#ent", "<e1>", "cancer", "and", "C0162628#ent", "<e2>"], "h": {"id": "C0242354", "name": "C0242354#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [17, 18]}}
{"token": ["Upon", "exposure", "to", "elevated", "growth", "temperatures", "mammalian", "cells", "a", "variety", "of", "cellular", "responses", "such", "as", "the", "expression", "of", "heat-shock", "proteins", "C3813609#ent", "<e1>", ")", "and", "the", "activation", "of", "C0291988#ent", "<e2>", "SAPK/JNK", ")", "."], "h": {"id": "C3813609", "name": "C3813609#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0291988", "name": "C0291988#ent", "pos": [27, 28]}}
{"token": ["This", "article", "reviews", "six", "defects", "of", "special", "importance", "in", "the", "care", "of", "children", ":", "aniridia", ",", "ectopia", "lentis", "cataracts", ",", "C0017601#ent", "<e1>", ",", "colobomata", ",", "and", "C0338502#ent", "<e2>"], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0338502", "name": "C0338502#ent", "pos": [26, 27]}}
{"token": ["p-Chloromercuribenzene-sulfonic", "acid", ",", "N", ",", "N'-dicyclohexylcarbodiimide", ",", "C0019873#ent", "<e1>", "and", "oligomycin", "inhibited", "both", "ATPase-", "and", "NADH-mediated", "C0018440#ent", "<e2>", "K(+)", "."], "h": {"id": "C0019873", "name": "C0019873#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018440", "name": "C0018440#ent", "pos": [16, 17]}}
{"token": ["C0389918#ent", "<e1>", "is", "now", "identified", "as", "a", "C1334706#ent", "<e2>", "belonging", "to", "the", "ADAMTS", "(", "A", "Disintegrin", "And", "Metalloproteinase", "domain", "with", "ThromboSpondin", "type", "1", "motif", "family", ",", "termed", "ADAMTS13", "."], "h": {"id": "C0389918", "name": "C0389918#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "the", "first", "identification", "of", "aberrant", "cathepsin", "K", "expression", "in", "hematopoietic", "tissue", "than", "osteoclasts", "implicates", "this", "C1947941#ent", "<e1>", "in", "the", "breakdown", "of", "the", "matrix", "that", "characterizes", "lytic", "bone", "lesions", "C1961835#ent", "<e2>"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [30, 31]}}
{"token": ["Plasma", "C3887648#ent", "<e1>", "and", "adrenaline", "concentrations", "remained", "nearly", "constant", "in", "the", "C0000503#ent", "<e2>", "and", "control", "groups", "declined", "during", "sedation", "with", "PRO", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000503", "name": "C0000503#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "the", "C0001975#ent", "<e1>", "was", "afforded", "by", "gas", "chromatography", "the", "C0000979#ent", "<e2>", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [11, 12]}}
{"token": ["To", "report", "an", "unusual", "case", "of", "C0023788#ent", "<e1>", "including", "uveitis", ",", "seronegative", "spondylarthropathy", "C0025297#ent", "<e2>", ",", "and", "lymphadenopathy", ",", "associated", "with", "Arthrobacter", "sp.", "infection"], "h": {"id": "C0023788", "name": "C0023788#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [13, 14]}}
{"token": ["By", "constructing", "strains", "in", "which", "CHC1", "expression", "is", "regulated", "by", "the", "GAL10", "promoter", "we", "demonstrate", "that", "the", "lethal", "alleles", "C3540808#ent", "<e1>", "and", "CDL1", "are", "C0017361#ent", "<e2>", "."], "h": {"id": "C3540808", "name": "C3540808#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [24, 25]}}
{"token": ["C1259877#ent", "<e1>", "depletion", "in", "mast", "cells", "calcium", "depletion", "the", "medium", "caused", "decreased", "tyrosine", "phosphorylation", "C0059239#ent", "<e2>", ",", "indicating", "that", "optimal", "tyrosine", "phosphorylation", "C0059239#ent", "<e2>", "is", "regulated", "by", "both", "pathways", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059239", "name": "C0059239#ent", "pos": [14, 15]}}
{"token": ["The", "protein", "with", "the", "lowest", "C0064494#ent", "<e1>", "identified", "in", "this", "study", "is", "the", "manganese", "ABC", "transporter", "C0086376#ent", "<e2>"], "h": {"id": "C0064494", "name": "C0064494#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}}
{"token": ["C0030310#ent", "<e1>", "was", "used", "as", "the", "C2911818#ent", "<e2>"], "h": {"id": "C0030310", "name": "C0030310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2911818", "name": "C2911818#ent", "pos": [6, 7]}}
{"token": ["C0030310#ent", "<e1>", "used", "as", "the", "C2911818#ent", "<e2>"], "h": {"id": "C0030310", "name": "C0030310#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2911818", "name": "C2911818#ent", "pos": [5, 6]}}
{"token": ["C0037707#ent", "<e1>", "slightly", "reduced", "C0042510#ent", "<e2>", "incidence", "only", "during", "reperfusion", "."], "h": {"id": "C0037707", "name": "C0037707#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [4, 5]}}
{"token": ["The", "effects", "of", "these", "compounds", "and", "also", "of", "18-hydroxydeoxycorticosterone", "were", "tested", "in", "cells", "stably", "transfected", "with", "CYP11B1", "and", "C1413857#ent", "<e1>", ",", "the", "genes", "encoding", "11beta-hydroxylase", "and", "C1527416#ent", "<e2>", "respectively", "."], "h": {"id": "C1413857", "name": "C1413857#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1527416", "name": "C1527416#ent", "pos": [26, 27]}}
{"token": ["Moreover", ",", "in", "the", "female", "offspring", "only", ",", "gross", "anatomical", "changes", "(", "cardiac", "ventricle", "body", "ratios", "and", "increased", "left", "cardiac", "ventricular", "atrial", "natriuretic", "peptide", "C1417807#ent", "<e1>", ")", "mRNA", "levels", "provide", "evidence", "for", "programming", "of", "C0018824#ent", "<e2>", "this", "gender", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [34, 35]}}
{"token": ["Analyses", "of", "28", "neuroblastoma", "tumor", "specimens", "and", "27", "cell", "lines", "the", "expression", "of", "C1705027#ent", "<e1>", "and", "a", "panel", "of", "C1417683#ent", "<e2>", "did", "not", "reveal", "any", "correlation", "between", "C1705027#ent", "<e1>", "and", "marker", "gene", "expression", "."], "h": {"id": "C1417683", "name": "C1417683#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705027", "name": "C1705027#ent", "pos": [13, 14]}}
{"token": ["Both", "of", "these", "effects", "may", "be", "beneficial", "in", "the", "use", "of", "C1868193#ent", "<e1>", "as", "an", "adjunct", "to", "C0010583#ent", "<e2>", "treatment", "."], "h": {"id": "C1868193", "name": "C1868193#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [17, 18]}}
{"token": ["This", "novel", "C0015296#ent", "<e1>", "and", "HSV", "C0012892#ent", "<e2>", "equally", "sensitive", "both", "to", "phosphonoacetic", "acid", "Zn2+", "ions", "inhibitors", "of", "the", "viral", "polymerase"], "h": {"id": "C0015296", "name": "C0015296#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [6, 7]}}
{"token": ["C1434623#ent", "<e1>", ",", "the", "product", "of", "sphingosine", "kinase", "C2987134#ent", "<e2>", ")", "activity", ",", "is", "a", "sphingolipid", "metabolite", "regulates", "cell", "growth", "survival", "and", "migration", "."], "h": {"id": "C1434623", "name": "C1434623#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987134", "name": "C2987134#ent", "pos": [8, 9]}}
{"token": ["C1522505#ent", "<e1>", "specifically", "induced", "expression", "of", "PC-1", "and", "C2827376#ent", "<e2>", "while", "inhibiting", "expression", "of", "TNAP", ",", "at", "both", "mRNA", "and", "protein", "levels"], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2827376", "name": "C2827376#ent", "pos": [8, 9]}}
{"token": ["We", "studied", "the", "osteoblastic", "abnormalities", "from", "activating", "mutation", "of", "the", "Gs", "alpha", "gene", "two", "patients", "with", "C0242292#ent", "<e1>", "one", "patient", "with", "C0016064#ent", "<e2>"], "h": {"id": "C0242292", "name": "C0242292#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0016064", "name": "C0016064#ent", "pos": [21, 22]}}
{"token": ["This", "study", "tested", "the", "hypothesis", "that", "C0017349#ent", "<e1>", "polymorphisms", "are", "important", "in", "susceptibility", "to", "BeS", "and", "C0006863#ent", "<e2>", "and", "that", "the", "Glu(69", ")", "variant", "is", "related", "to", "markers", "of", "disease", "severity"], "h": {"id": "C0017349", "name": "C0017349#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006863", "name": "C0006863#ent", "pos": [16, 17]}}
{"token": ["Analysis", "of", "the", "nucleotide", "sequence", "the", "isophthalate", "degradation", "operon", "C1417679#ent", "<e1>", "for", "a", "dioxygenase", ",", "a", "transport", "protein", "a", "C1721278#ent", "<e2>", "and", "a", "reductase", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1721278", "name": "C1721278#ent", "pos": [19, 20]}}
{"token": ["C0586989#ent", "<e1>", "children", "can", "be", "complicated", "by", "C0398650#ent", "<e2>", "ITP", ")", "."], "h": {"id": "C0586989", "name": "C0586989#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0398650", "name": "C0398650#ent", "pos": [7, 8]}}
{"token": ["The", "transcription", "of", "major", "C0024518#ent", "<e1>", "MHC", "II", "genes", "is", "dependent", "on", "the", "co-activator", "protein", "class", "II", "trans-activator", "C1824738#ent", "<e2>", ")", "."], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1824738", "name": "C1824738#ent", "pos": [18, 19]}}
{"token": ["We", "also", "show", "that", "FTI-277", "and", "GGTI-298", "block", "C0038838#ent", "<e1>", "production", "stimulated", "by", "constitutively", "active", "mutant", "C0079471#ent", "<e2>", "."], "h": {"id": "C0038838", "name": "C0038838#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [16, 17]}}
{"token": ["After", "injection", "of", "C1875400#ent", "<e1>", "and", "vaccine", "virus", "the", "C0023218#ent", "<e2>", "inclusion", "bodies", "were", "observed", "in", "the", "ganglion", "cells", "the", "spinal", "cord"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023218", "name": "C0023218#ent", "pos": [9, 10]}}
{"token": ["Since", ",", "C0006109#ent", "<e1>", "such", "as", "fibromyalgia", "and", "C0038013#ent", "<e2>", "may", "be", "triggered", "and/or", "exacerbated", "by", "chronic", "stress", "we", "have", "evaluated", "the", "effect", "of", "repeated", "stress", "on", "mechanical", "nociceptive", "threshold", "and", "inflammatory", "hyperalgesia"], "h": {"id": "C0006109", "name": "C0006109#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [8, 9]}}
{"token": ["The", "beta-adrenergic", "antagonist", "propranolol", ",", "but", "not", "the", "C3536752#ent", "<e1>", "phentolamine", ",", "blocked", "the", "desensitizing", "effects", "of", "C0022245#ent", "<e2>", "."], "h": {"id": "C3536752", "name": "C3536752#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [17, 18]}}
{"token": ["A", "diagnosis", "of", "C0006625#ent", "<e1>", "made", ",", "and", "he", "responded", "to", "C3714642#ent", "<e2>", "and", "fluid", "loading", "."], "h": {"id": "C0006625", "name": "C0006625#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [11, 12]}}
{"token": ["Transcription", "of", "T7", "and", "phi", "29", "C0011522#ent", "<e1>", "was", "stimulated", "by", "KCl", ",", "whereas", "transcription", "of", "C1417510#ent", "<e2>", ",", "Mx4", ",", "and", "Mx8", "C0011522#ent", "<e1>", "was", "inhibited", "by", "KCl", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417510", "name": "C1417510#ent", "pos": [16, 17]}}
{"token": ["Gastrointestinal", "dysmotility", "the", "most", "prominent", "manifestation", ",", "with", "C0401151#ent", "<e1>", "borborygmi", ",", "and", "C0021847#ent", "<e2>"], "h": {"id": "C0401151", "name": "C0401151#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [13, 14]}}
{"token": ["Etanercept", "did", "not", "modify", "insulin", "secretion", "insulin", "sensitivity", "C0003872#ent", "<e1>", "patients", "with", "risk", "factors", "C0011854#ent", "<e2>"], "h": {"id": "C0003872", "name": "C0003872#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [14, 15]}}
{"token": ["We", "confirmed", "that", "C.", "latirostris", "is", "a", "species", "with", "C1332805#ent", "<e1>", "and", "additionally", "demonstrated", "that", "C3539739#ent", "<e2>", "causes", "estrogen-like", "developmental", "effects", "reversing", "gonadal", "sex", "altering", "gonadal", "histoarchitecture", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539739", "name": "C3539739#ent", "pos": [15, 16]}}
{"token": ["The", "two", "C1334863#ent", "<e1>", "chains", "bear", "polysialic", "acid", "PSA", ")", "and", "migrate", "in", "sodium", "dodecyl", "sulfate", "C3273614#ent", "<e2>", ")", "gels", "as", "a", "diffuse", ",", "high", "Mr", "component", ",", "as", "has", "been", "observed", "in", "fetal", "brain"], "h": {"id": "C1334863", "name": "C1334863#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273614", "name": "C3273614#ent", "pos": [16, 17]}}
{"token": ["Deficiency", "of", "C0751039#ent", "<e1>", "in", "humans", "leads", "to", "C0007804#ent", "<e2>", "accumulation", "and", "neurodegenerative", "disease"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [8, 9]}}
{"token": ["The", "strategies", "these", "women", "use", "to", "reduce", "negative", "affect", "secondary", "to", "C0751039#ent", "<e1>", ",", "such", "as", "sexual", "contact", "may", "mediate", "the", "link", "between", "C0751039#ent", "<e1>", "and", "later", "C0007804#ent", "<e1>", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [27, 28]}}
{"token": ["At", "all", "times", "studied", "the", "foci", "exhibited", "a", "low", "labeling", "index", "C1420713#ent", "<e1>", ")", ",", "and", "liver", "C1422630#ent", "<e2>", "activity", "was", "near", "control", "values", "."], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422630", "name": "C1422630#ent", "pos": [17, 18]}}
{"token": ["A", "43-year-old", "female", "with", "adrenoleukodystrophy", "(", "C0162309#ent", "<e1>", ")", "is", "described", ",", "who", "developed", "spastic", "tetraparesis", "suffered", "C0036572#ent", "<e2>", "and", "became", "stuporous", "and", "demented", "during", "the", "last", "5", "years", "of", "her", "life", "."], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [17, 18]}}
{"token": ["SCRL-bound", "GPI(+", ")", "C0074202#ent", "<e1>", "was", "not", "converted", "to", "PrP-res", "until", "C1538607#ent", "<e2>", "was", "added", "to", "the", "reaction", "or", "the", "combined", "membrane", "fractions", "treated", "with", "membrane-fusing", "agent", "polyethylene", "glycol", "PEG", ")", "."], "h": {"id": "C0074202", "name": "C0074202#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1538607", "name": "C1538607#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "SCRL-bound", "GPI(-", ")", "C0074202#ent", "<e1>", "was", "converted", "to", "PrP-res", "without", "C1538607#ent", "<e2>", "or", "PEG", "treatment", "."], "h": {"id": "C0074202", "name": "C0074202#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538607", "name": "C1538607#ent", "pos": [13, 14]}}
{"token": ["Early", "results", "have", "demonstrated", "the", "presence", "of", "C1335216#ent", "<e1>", "PI4K", "activity", "in", "glucose", "transporter", "4", "C1420175#ent", "<e2>", ")", "vesicles", "from", "fat", "and", "skeletal", "muscle", "cells"], "h": {"id": "C1335216", "name": "C1335216#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [15, 16]}}
{"token": ["The", "biosynthesis", "of", "androgen", "requires", "the", "steroidogenic", "acute", "regulatory", "protein", "StAR", ")", "and", "the", "steroidogenic", "enzymes", "P450scc", "3", "beta", "HSDII", ",", "C1413858#ent", "<e1>", ",", "17", "beta", "HSDIII", ",", "and", "5", "C0055533#ent", "<e2>", "."], "h": {"id": "C1413858", "name": "C1413858#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0055533", "name": "C0055533#ent", "pos": [30, 31]}}
{"token": ["In", "addition", "to", "19", "C0235267#ent", "<e1>", "initially", "fitted", "with", "C1705010#ent", "<e2>", "lenses", ",", "there", "were", "99", "C0235267#ent", "<e1>", "initially", "wearing", "PMMA", "lenses", "that", "were", "subsequently", "refitted", "with", "C1705010#ent", "<e2>", "scleral", "lenses"], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705010", "name": "C1705010#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "this", "study", "is", "to", "evaluate", "C0003392#ent", "<e1>", "properties", "of", "a", "combination", "of", "Fas", "ligand", "C1706006#ent", "<e2>", ")", "plus", "etoposide", "with", "or", "without", "dexamethasone", "on", "intracerebral", "experimental", "glioblastomas", "."], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [17, 18]}}
{"token": ["Intrahepatic", "virus-specific", "CD8", "+", "T", "cells", "displayed", "significantly", "reduced", "levels", "of", "C1334123#ent", "<e1>", "expression", "but", "similar", "levels", "of", "C1416687#ent", "<e2>", "expression", "compared", "to", "the", "peripheral", "blood"], "h": {"id": "C1334123", "name": "C1334123#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416687", "name": "C1416687#ent", "pos": [18, 19]}}
{"token": ["The", "enzyme", "was", "an", "AMP-forming", "CoA", "ligase", "a", "Km", "=", "14.7", "microM", "for", "C0047450#ent", "<e1>", "8.5", "microM", "for", "coenzyme", "A", "229", "microM", "for", "C1705556#ent", "<e2>", "."], "h": {"id": "C0047450", "name": "C0047450#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [23, 24]}}
{"token": ["The", "DNase", "I-protection", "assay", "revealed", "that", "Fur", "specifically", "binds", "to", "the", "C1704661#ent", "<e1>", "in", "the", "promoter", "region", "the", "fhu", "C0029073#ent", "<e2>", "."], "h": {"id": "C1704661", "name": "C1704661#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [19, 20]}}
{"token": ["hupA", "and", "this", "open", "reading", "frame", "likely", "organized", "in", "an", "C0029073#ent", "<e1>", ",", "and", "a", "sequence", "homologous", "to", "the", "Escherichia", "coli", "consensus", "C1704661#ent", "<e2>", "present", "in", "the", "putative", "promoter", "region", "the", "C0029073#ent", "<e1>", "."], "h": {"id": "C1704661", "name": "C1704661#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [10, 11]}}
{"token": ["C0021246#ent", "<e1>", "failed", "to", "inhibit", "the", "LTB4-induced", "increases", "in", "C1427198#ent", "<e2>", "and", "W/D", "ratio", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1427198", "name": "C1427198#ent", "pos": [9, 10]}}
{"token": ["Definition", "of", "hemoglobin", "A", "cellulose", "acetate", "electrophoretograms", "eluate", "from", "air-dried", "specimens", "of", "newborns'", "blood", "was", "improved", "by", "adding", "C0886275#ent", "<e1>", "to", "the", "Tris", "--", "C0013618#ent", "<e2>", "borate", "buffer", "system"], "h": {"id": "C0886275", "name": "C0886275#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [24, 25]}}
{"token": ["Segments", "with", "similarity", "contain", "the", "three", "enkephalin", "sequences", "preprodynorphin", "and", "one", "in", "C0071924#ent", "<e1>", "which", "are", "present", "within", "heptapeptide", "repeats", "characteristic", "of", "an", "C1539075#ent", "<e2>", "of", "an", "amphipathic", "helix-loop-helix", "DNA-binding", "motif"], "h": {"id": "C0071924", "name": "C0071924#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539075", "name": "C1539075#ent", "pos": [23, 24]}}
{"token": ["Administration", "of", "C0027360#ent", "<e1>", "completely", "blocked", "the", "analgesic", "effects", "C0175697#ent", "<e2>", "4", "h", "after", "its", "administration", ",", "but", "had", "no", "effect", "LPS-induced", "suppression", "of", "activity", "in", "the", "open", "field"], "h": {"id": "C0027360", "name": "C0027360#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [9, 10]}}
{"token": ["An", "Fn", "index", "to", "estimate", "the", "rate", "of", "intrathecal", "C1706331#ent", "<e1>", "synthesis", "reached", "the", "highest", "value", "in", "C0085437#ent", "<e2>"], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085437", "name": "C0085437#ent", "pos": [17, 18]}}
{"token": ["Chronic", "non-specific", "sialadenitis", "the", "parotid", "gland", "an", "insidious", "C1290884#ent", "<e1>", "is", "characterised", "by", "intermittent", ",", "often", "C0239377#ent", "<e2>", ",", "swelling", "of", "the", "gland", "."], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [16, 17]}}
{"token": ["The", "obtained", "C0038760#ent", "<e1>", "are", "potential", "C3536863#ent", "<e2>", "for", "lithium", "batteries", "fuel", "cells", "."], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [6, 7]}}
{"token": ["In", "contrast", ",", "chronic", "blockade", "C1412245#ent", "<e1>", "to", "reduce", "increased", "C3543842#ent", "<e2>", "G-protein", "signaling", "the", "spinal", "cord", "nerve", "injury"], "h": {"id": "C1412245", "name": "C1412245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [10, 11]}}
{"token": ["The", "enzyme", "with", "altered", "specificity", ",", "designated", "Bam", "HI.1", ",", "generated", "digestion", "patterns", "of", "various", "C0011519#ent", "<e1>", ",", "which", "were", "distinct", "from", "those", "generated", "by", "C1704469#ent", "<e2>"], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704469", "name": "C1704469#ent", "pos": [25, 26]}}
{"token": ["Two", "patients", "had", "colonic", "perforation", "associated", "with", "C0012819#ent", "<e1>", "one", "necrosis", "of", "the", "terminal", "ileum", "and", "one", "C0085693#ent", "<e2>"], "h": {"id": "C0012819", "name": "C0012819#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085693", "name": "C0085693#ent", "pos": [17, 18]}}
{"token": ["Hereditary", "sensory", "neuropathies", "C3541309#ent", "<e1>", ")", ",", "also", "known", "as", "hereditary", "sensory", "C0259749#ent", "<e2>", "HSAN", ")", ",", "are", "a", "clinically", "and", "genetically", "heterogeneous", "group", "of", "disorders", "."], "h": {"id": "C3541309", "name": "C3541309#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0259749", "name": "C0259749#ent", "pos": [12, 13]}}
{"token": ["Noonan", "syndrome", "now", "known", "to", "be", "associated", "with", "mutations", "in", "the", "C1335280#ent", "<e1>", "encoding", "the", "protein", "tyrosine", "phosphatase", "SHP-2", "on", "C0795843#ent", "<e2>", "12q24.1", ")", "."], "h": {"id": "C1335280", "name": "C1335280#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0795843", "name": "C0795843#ent", "pos": [20, 21]}}
{"token": ["High", "C0002484#ent", "<e1>", "together", "with", "weight", "gain", "more", "than", "2", "kg", "and", "insulin", "C1417509#ent", "<e2>", "features", "in", "the", "subcohort", "were", "sought", "for", "up", "to", "5", "years", "."], "h": {"id": "C0002484", "name": "C0002484#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417509", "name": "C1417509#ent", "pos": [13, 14]}}
{"token": ["External", "C0030293#ent", "<e1>", "found", "in", "83", "%", ",", "C0011847#ent", "<e2>", "in", "14", "%", "."], "h": {"id": "C0030293", "name": "C0030293#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [8, 9]}}
{"token": ["Myocardial", "expressions", "C1414518#ent", "<e1>", "mRNA", ",", "an", "C0027203#ent", "<e2>", "involved", "in", "fatty", "acid", "utilization", ",", "was", "markedly", "decreased", "in", "the", "CoCl2-treated", "rats", "."], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}}
{"token": ["In", "the", "presence", "of", "varying", "concentrations", "of", "C1422492#ent", "<e1>", "and", "ATP", ",", "the", "C0031644#ent", "<e2>", "from", "V.", "parvula", "exhibited", "hyperbolic", "kinetics", "with", "KmS", "of", "0.16", "and", "0.46", "mM", ",", "respectively", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031644", "name": "C0031644#ent", "pos": [13, 14]}}
{"token": ["The", "influence", "of", "caffeine", "on", "the", "efficiency", "of", "C1413043#ent", "<e1>", "+", "transport", "in", "the", "presence", "of", "C3669135#ent", "<e2>", "by", "different", "fractions", "of", "sarcoplasmic", "reticulum", "SR", ")", "membranes", "from", "rabbit", "skeletal", "muscle", "studied", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3669135", "name": "C3669135#ent", "pos": [16, 17]}}
{"token": ["The", "purified", "plasma", "membranes", "rat", "gastric", "fundus", "muscle", "which", "elicit", "the", "stimulation", "of", "ATP-dependent", "C1413043#ent", "<e1>", "+", "accumulation", "by", "inorganic", "phosphate", "not", "by", "C3669135#ent", "<e2>", ",", "were", "used", "as", "a", "control", "reference"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3669135", "name": "C3669135#ent", "pos": [23, 24]}}
{"token": ["The", "removal", "of", "C1413043#ent", "<e1>", "+", "ions", "by", "C3669135#ent", "<e2>", "causes", "about", "20", "%", "inhibition", ";", "the", "activity", "was", "restored", "by", "addition", "of", "C1413043#ent", "<e1>", "+", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3669135", "name": "C3669135#ent", "pos": [8, 9]}}
{"token": ["To", "identify", "the", "defective", "C0017337#ent", "<e1>", ",", "mitochondrial", "DNA", "a", "patient", "with", "C0162671#ent", "<e2>", "was", "sequenced", "by", "using", "amplified", "DNA", "fragments", "sequencing", "templates"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162671", "name": "C0162671#ent", "pos": [12, 13]}}
{"token": ["Changes", "in", "C0014442#ent", "<e1>", "(", "reduced", "nicotinamide", "adenine", "dinucleotide-dehydrogenase", "cytochrome", "c", "oxidase", "activities", "and", "C3815884#ent", "<e2>", "MHC", ")", "composition", "were", "measured", "in", "the", "left", "ventricle"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3815884", "name": "C3815884#ent", "pos": [14, 15]}}
{"token": ["The", "purified", "C0014442#ent", "<e1>", "catalyzed", "the", "cross-linking", "of", "C3815884#ent", "<e2>", "from", "Alaska", "pollack", "resulting", "in", "gelation", "of", "an", "actomyosin", "solution"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3815884", "name": "C3815884#ent", "pos": [8, 9]}}
{"token": ["Granzyme", "B", "C3538708#ent", "<e1>", ")", "is", "a", "C0072402#ent", "<e2>", "released", "by", "cytotoxic", "lymphocytes", "CLs", ")", "to", "kill", "abnormal", "cells"], "h": {"id": "C3538708", "name": "C3538708#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [7, 8]}}
{"token": ["Seven", "days", "after", "MPTP", "treatment", ",", "BrdU-positive", "cells", "were", "significantly", "increased", "in", "the", "C1416825#ent", "<e1>", ",", "especially", "in", "the", "C0268731#ent", "<e2>", "GL", ")", "and", "the", "subependymal", "zone", "SEZ", ")", "."], "h": {"id": "C1416825", "name": "C1416825#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [19, 20]}}
{"token": ["Expression", "of", "the", "dopaminergic", "phenotype", "olfactory", "bulb", "C1416825#ent", "<e1>", ")", "juxtaglomerular", "neurons", "(", "constituting", "a", "population", "of", "C0268731#ent", "<e2>", "and", "external", "tufted", "cells", ")", "is", "dependent", "upon", "functional", "innervation", "by", "peripheral", "olfactory", "receptors"], "h": {"id": "C1416825", "name": "C1416825#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [17, 18]}}
{"token": ["C1413508#ent", "<e1>", ",", "a", "member", "of", "the", "C3890018#ent", "<e2>", "(", "heat-shock", "protein", "100", "family", ",", "functions", "as", "a", "molecular", "chaperone", "is", "a", "regulatory", "subunit", "the", "ClpXP", "protease", "."], "h": {"id": "C1413508", "name": "C1413508#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [7, 8]}}
{"token": ["We", "conclude", "that", "NB-UVB", "in", "conjunction", "with", "C0050559#ent", "<e1>", "is", "a", "potent", "therapeutic", "regimen", "the", "treatment", "of", "severe", "C0152081#ent", "<e2>", "Zumbusch", "type", "in", "childhood", "."], "h": {"id": "C0050559", "name": "C0050559#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0152081", "name": "C0152081#ent", "pos": [18, 19]}}
{"token": ["C1172090#ent", "<e1>", "is", "the", "catalytic", "subunit", "C1413290#ent", "<e2>", "(", "cyclinT1/P-TEFb", ")", ",", "a", "cellular", "protein", "kinase", "mediates", "human", "immunodeficiency", "virus", "type", "1", "HIV-1", ")", "Tat", "transcriptional", "activation", "function", "."], "h": {"id": "C1172090", "name": "C1172090#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413290", "name": "C1413290#ent", "pos": [6, 7]}}
{"token": ["We", "report", "the", "case", "of", "a", "24", "year", "old", "woman", "who", "developed", "C0026896#ent", "<e1>", "the", "course", "of", "a", "mild", "form", "of", "C0007959#ent", "<e2>"], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0007959", "name": "C0007959#ent", "pos": [21, 22]}}
{"token": ["She", "received", "a", "non-steroidal", "anti-inflammatory", "agent", "C0038792#ent", "<e1>", ")", "because", "of", "C0003873#ent", "<e2>"], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}}
{"token": ["All", "three", "diffuse", "large", "B-cell", "lymphomas", "were", "positive", "for", "BCL-6", ",", "two", "were", "positive", "for", "C0025250#ent", "<e1>", ",", "and", "two", "were", "positive", "for", "C0376515#ent", "<e2>", "."], "h": {"id": "C0025250", "name": "C0025250#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [23, 24]}}
{"token": ["Therefore", ",", "C0012586#ent", "<e1>", ",", "in", "contrast", "to", "C2350083#ent", "<e2>", "and", "indomethacin", ",", "exhibits", "spasmolytic", "activity", "addition", "to", "analgesia", "in", "biliary", "pain"], "h": {"id": "C0012586", "name": "C0012586#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2350083", "name": "C2350083#ent", "pos": [8, 9]}}
{"token": ["The", "most", "common", "C0025517#ent", "<e1>", "be", "considered", "are", "organic", "acidurias", "C0002514#ent", "<e2>", "by", "urea", "cycle", "disorders", "congenital", "lactic", "acidosis", "peroxisomal", "disorders", "and", ",", "less", "frequently", ",", "sphingolipidoses", ",", "mucopolysaccharidoses", ",", "glycoprotein", "degradation", "disorders", "fatty", "acid", "oxidation", "disorders", "and", "neuronal", "ceroid", "lipofuscinoses"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0002514", "name": "C0002514#ent", "pos": [10, 11]}}
{"token": ["We", "evaluated", "the", "effects", "of", "C0054836#ent", "<e1>", "and", "metoprolol", "on", "C0751039#ent", "<e2>", "level", "when", "initiated", "in", "cardiac", "transplant", "recipients", "."], "h": {"id": "C0054836", "name": "C0054836#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [10, 11]}}
{"token": ["It", "dephosphorylates", "acidic", "phosphoproteins", "casein", "and", "phosvitin", ")", ",", "ATP", ",", "and", "C0134796#ent", "<e1>", "but", "not", "basic", "C0031686#ent", "<e2>", "(", "histones", "and", "protamine", "phosphate", "."], "h": {"id": "C0134796", "name": "C0134796#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [17, 18]}}
{"token": ["The", "combination", "of", "headache", ",", "acute", "visual", "loss", "and", "ipsilateral", "Horner", "syndrome", "ophthalmoplegia", ",", "which", "may", "suggest", "C0751815#ent", "<e1>", "is", "evidently", "an", "unusual", "manifestation", "of", "C0038454#ent", "<e2>"], "h": {"id": "C0751815", "name": "C0751815#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [25, 26]}}
{"token": ["ABVD", "consists", "of", "6", "cycles", "of", "C0014582#ent", "<e1>", ",", "bleomycin", ",", "vinblastine", ",", "and", "C0392206#ent", "<e2>"], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0392206", "name": "C0392206#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "C0014582#ent", "<e1>", "were", "compared", "to", "a", "combination", "program", "methyl-CCNU", "and", "C0392206#ent", "<e2>", "DTIC", ")", "in", "44", "patients", "with", "disseminated", "malignant", "melanoma"], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0392206", "name": "C0392206#ent", "pos": [13, 14]}}
{"token": ["In", "Rat1a", "fibroblasts", "and", "murine", "livers", "overexpressing", "C0079068#ent", "<e1>", ",", "the", "mRNA", "levels", "of", "the", "glucose", "transporter", "C1705603#ent", "<e2>", ",", "phosphoglucose", "isomerase", "phosphofructokinase", ",", "glyceraldehyde-3-phosphate", "dehydrogenase", "phosphoglycerate", "kinase", "and", "enolase", "were", "elevated", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705603", "name": "C1705603#ent", "pos": [17, 18]}}
{"token": ["Our", "data", "constitute", "the", "first", "demonstration", "that", "C1419407#ent", "<e1>", "and", "Cdc42Hs", "control", "pathways", "require", "simultaneous", "signalling", "through", "MAPK", "C1366882#ent", "<e2>", "and", "p53", "to", "induce", "apoptosis", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [18, 19]}}
{"token": ["C1419407#ent", "<e1>", "may", "stimulate", "the", "C1366882#ent", "<e2>", "cascade", "either", "by", "promoting", "the", "phosphorylation", "of", "c-Raf", "or", "by", "increasing", "MEK1", "and/or", "-2", "association", "with", "c-Raf", "to", "facilitate", "MEK1", "and/or", "-2", "activation"], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [5, 6]}}
{"token": ["Other", "vaccine", "programmes", "are", "concerned", "with", "C0017536#ent", "<e1>", ",", "filariasis", ",", "toxoplasmosis", ",", "fascioliasis", ",", "C1299919#ent", "<e2>", "in", "poultry", ",", "cutaneous", "leishmaniasis", "schistosomiasis", "japonica"], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1299919", "name": "C1299919#ent", "pos": [15, 16]}}
{"token": ["Mean", "changes", "from", "baseline", "in", "C0242852#ent", "<e1>", "and", "CD4", "cell", "count", "evaluated", "using", "C1413903#ent", "<e2>", "and", "an", "ITT", "mixed-model", "approach", "."], "h": {"id": "C0242852", "name": "C0242852#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413903", "name": "C1413903#ent", "pos": [13, 14]}}
{"token": ["Orally", "administered", "C0018242#ent", "<e1>", "remains", "the", "standard", "treatment", "C0040250#ent", "<e2>"], "h": {"id": "C0018242", "name": "C0018242#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0040250", "name": "C0040250#ent", "pos": [8, 9]}}
{"token": ["We", "conducted", "an", "open-label", "study", "evaluate", "the", "effects", "of", "a", "lower", "pharmacologic", "dose", "C3539616#ent", "<e1>", "(", "3", "mg/d", ")", "in", "eight", "men", "with", "C0019686#ent", "<e2>", "accumulation", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019686", "name": "C0019686#ent", "pos": [23, 24]}}
{"token": ["We", "concluded", "that", "C3539616#ent", "<e1>", "treatment-induced", "LBM", "gains", "in", "C0019686#ent", "<e2>", "functionally", "relevant", ",", "as", "determined", "by", "effort-independent", "submaximal", "measures", "of", "cardiopulmonary", "exercise", "testing"], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019686", "name": "C0019686#ent", "pos": [9, 10]}}
{"token": ["RA", "increased", "the", "incorporation", "of", "C0017718#ent", "<e1>", "and", "galactose", "but", "not", "mannose", "into", "high", "molecular", "weight", "C1537471#ent", "<e2>", ")", "glycoconjugates", "of", "about", "220", "and", "500", "-", "600", "kDa", "."], "h": {"id": "C0017718", "name": "C0017718#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1537471", "name": "C1537471#ent", "pos": [16, 17]}}
{"token": ["To", "assess", "the", "ability", "of", "rheumatoid", "arthritis", "RA", ")", "fibroblast-like", "synoviocytes", "(", "C3540811#ent", "<e1>", ")", "to", "function", "as", "antigen-presenting", "cells", "C0033036#ent", "<e2>", ")", "for", "arthritogenic", "autoantigens", "within", "inflamed", "joint", "tissues"], "h": {"id": "C3540811", "name": "C3540811#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [20, 21]}}
{"token": ["We", "present", "a", "characterization", "of", "the", "native", "T3SS", "ATPase", ",", "Spa47", ",", "from", "the", "cytoplasm", "of", "C0302359#ent", "<e1>", "demonstrating", "it", "to", "be", "in", "two", "distinct", "high-molecular-weight", "complexes", "C1364020#ent", "<e2>", ":", "MxiN", "and", "MxiK."], "h": {"id": "C0302359", "name": "C0302359#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1364020", "name": "C1364020#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "we", "demonstrate", "that", "SUMO", "protease", "C1366763#ent", "<e1>", "interacts", "with", "HIPK2", ",", "and", "both", "C0086376#ent", "<e2>", "predominantly", "colocalize", "in", "promyelocytic", "leukemia-nuclear", "bodies"], "h": {"id": "C1366763", "name": "C1366763#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["Structural", "analysis", "that", "MAK248", "is", "a", "novel", "CRISP", "protein", "a", "member", "of", "the", "CAP", "(", "CRISP", ",", "Ag", "5", "C1366763#ent", "<e1>", ")", "family", "of", "C0086376#ent", "<e2>", "."], "h": {"id": "C1366763", "name": "C1366763#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [24, 25]}}
{"token": ["Herein", ",", "we", "describe", "a", "patient", "with", "C4053959#ent", "<e1>", "treated", "with", "immunoglobulin", "preparation", "maltose", "who", "developed", "C0022660#ent", "<e2>", "with", "histologic", "changes", "characterized", "by", "vacuolization", "and", "swelling", "of", "renal", "proximal", "tubular", "cells"], "h": {"id": "C4053959", "name": "C4053959#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [16, 17]}}
{"token": ["The", "gene", "encoding", "the", "elongation", "factor", "2", "the", "hyperthermophilic", "archaeon", "Sulfolobus", "solfataricus", "C3811072#ent", "<e1>", ")", "was", "expressed", "in", "Escherichia", "coli", "the", "C1421837#ent", "<e2>", "-", "7", "expression", "vector"], "h": {"id": "C3811072", "name": "C3811072#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421837", "name": "C1421837#ent", "pos": [21, 22]}}
{"token": ["To", "examine", "the", "role", "of", "C3537004#ent", "<e1>", "and", "sympathomimetic", "drugs", "preventing", "gastric", "ulcerogenesis", "cervical", "cord", "transection", "C1413193#ent", "<e2>", ")", "in", "the", "rat", "."], "h": {"id": "C3537004", "name": "C3537004#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413193", "name": "C1413193#ent", "pos": [16, 17]}}
{"token": ["C0065180#ent", "<e1>", "significantly", "attenuated", "platelet-activating", "factor", "C0014457#ent", "<e2>", "chemotaxis", "and", "O2-", "generation", "at", "therapeutic", "concentrations", "equivalent", "to", "serum", "concentrations", "after", "single", "oral", "administration", "20", "mg", "or", "40", "mg", ")", "."], "h": {"id": "C0065180", "name": "C0065180#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [6, 7]}}
{"token": ["C0003499#ent", "<e1>", "a", "rare", "cause", "of", "C0042512#ent", "<e2>", "adults", "."], "h": {"id": "C0003499", "name": "C0003499#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042512", "name": "C0042512#ent", "pos": [6, 7]}}
{"token": ["The", "conserved", "RasGEF", "Cdc25", "is", "a", "likely", "control", "point", "because", "C0022541#ent", "<e1>", "and", "Fus3", "complexes", "associate", "with", "and", "phosphorylate", "C1413259#ent", "<e2>", "."], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413259", "name": "C1413259#ent", "pos": [19, 20]}}
{"token": ["All", "four", "of", "these", "C3537219#ent", "<e1>", "were", "constitutively", "produced", "and", "utilized", "the", "C0301713#ent", "<e2>", "phenylalanine", ",", "and", "tyrosine", "as", "amino", "substrates", "."], "h": {"id": "C3537219", "name": "C3537219#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0301713", "name": "C0301713#ent", "pos": [12, 13]}}
{"token": ["The", "amino-terminal", "sequence", "of", "Physarum", "vitronectin-like", "protein", "is", ",", "however", ",", "distinct", "from", "those", "of", "C1336937#ent", "<e1>", "shows", "significant", "sequence", "homology", "with", "C0058087#ent", "<e2>", "a", "component", "of", "pyruvate", "dehydrogenase", "complex"], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0058087", "name": "C0058087#ent", "pos": [22, 23]}}
{"token": ["We", "also", "examined", "whether", "C1427914#ent", "<e1>", "interacts", "with", "selective", "C2911696#ent", "<e2>", "SSRIs", ")", "using", "MDCK", "cells", "expressing", "recombinant", "human", "C1427914#ent", "<e1>", "."], "h": {"id": "C1427914", "name": "C1427914#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2911696", "name": "C2911696#ent", "pos": [9, 10]}}
{"token": ["The", "C3889383#ent", "<e1>", "increased", "lipid", "content", "blocked", "the", "ability", "of", "C0770893#ent", "<e2>", "to", "decrease", "lipid", "accumulation", "by", "high", "glucose", "concentrations", "."], "h": {"id": "C3889383", "name": "C3889383#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [10, 11]}}
{"token": ["Sixteen", "steroid", "dependent", "and", "13", "steroid", "independent", "patients", "with", "C0004096#ent", "<e1>", "treated", "for", "three", "months", "with", "C0060501#ent", "<e2>", "by", "aerosol", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0060501", "name": "C0060501#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "present", "2", "cases", "of", "falciparum", "C0024530#ent", "<e1>", "treated", "with", "intravenous", "60-mg", "doses", "of", "C0142801#ent", "<e2>"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0142801", "name": "C0142801#ent", "pos": [15, 16]}}
{"token": ["Almost", "all", "CMC", "(", "90", "%", ")", "reacted", "with", "MoAbs", "against", "tryptase", "and", "C4084825#ent", "<e1>", "and", "thus", "were", "C3811697#ent", "<e2>", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3811697", "name": "C3811697#ent", "pos": [18, 19]}}
{"token": ["Because", "C1705360#ent", "<e1>", "children", "generally", "tend", "to", "demonstrate", "deviated", "IQ-school", "performance", "correlation", ",", "we", "conclude", "that", "the", "WISC-R", "and", "C1418963#ent", "<e2>", "are", "appropriate", "for", "two-axial", "screening", "of", "C1705360#ent", "<e1>", "."], "h": {"id": "C1418963", "name": "C1418963#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [1, 2]}}
{"token": ["injection", "of", "C1299870#ent", "<e1>", "treatment", "of", "C0686716#ent", "<e2>", "3", "dogs", "are", "described", "."], "h": {"id": "C1299870", "name": "C1299870#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0686716", "name": "C0686716#ent", "pos": [6, 7]}}
{"token": ["Opioids", "are", "given", "for", "acute", "intra-", "and", "C0030201#ent", "<e1>", "relief", "or", "for", "C1333034#ent", "<e2>"], "h": {"id": "C0030201", "name": "C0030201#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333034", "name": "C1333034#ent", "pos": [12, 13]}}
{"token": ["A", "significant", "difference", "between", "the", "C1839576#ent", "<e1>", "value", "of", "each", "drug", "except", "for", "C0771774#ent", "<e2>", "in", "the", "aorta", "and", "in", "prostate", "was", "observed", "(", "p", "<", "0.01", ")", "."], "h": {"id": "C1839576", "name": "C1839576#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0771774", "name": "C0771774#ent", "pos": [13, 14]}}
{"token": ["Highly", "purified", "C1412057#ent", "<e1>", "pig", "brain", "is", "susceptible", "to", "phosphorylation", "by", "the", "purified", "C1514549#ent", "<e2>"], "h": {"id": "C1412057", "name": "C1412057#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1514549", "name": "C1514549#ent", "pos": [13, 14]}}
{"token": ["After", "liver", "transplantation", "humans", ",", "C0008370#ent", "<e1>", "associated", "with", "acute", "rejection", "nonspecific", "C0008370#ent", "<e1>", "can", "not", "be", "attributed", "directly", "to", "the", "effect", "of", "C0010592#ent", "<e1>", "."], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [23, 24]}}
{"token": ["Although", "the", "results", "may", "implicate", "C1307053#ent", "<e1>", "as", "an", "C0021053#ent", "<e2>", "nonspecific", "factors", "could", "not", "be", "ruled", "out", "."], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021053", "name": "C0021053#ent", "pos": [9, 10]}}
{"token": ["The", "incidence", "of", "GI", "disease", "the", "structure", "and", "function", "of", "the", "GI", "tract", "been", "studied", "systematically", "in", "41", "patients", "with", "C0001175#ent", "<e1>", "IDS", ")", "and", "in", "9", "patients", "with", "chronic", "granulomatous", "diesase", "C1863999#ent", "<e2>", ")", "."], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1863999", "name": "C1863999#ent", "pos": [32, 33]}}
{"token": ["A", "fatal", "case", "of", "C0220710#ent", "<e1>", "described", "in", "a", "patient", "who", "presented", "with", "C0020615#ent", "<e2>", "and", "a", "gross", "non-ketotic", "dicarboxylic", "aciduria", "."], "h": {"id": "C0220710", "name": "C0220710#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [13, 14]}}
{"token": ["In", "line", "with", "this", "hypothesis", ",", "recent", "findings", "suggest", "that", "enhanced", "adrenal", "release", "epinephrine", "and", "exaggerated", "cardiovascular", "responsiveness", "catecholamines", "both", "contribute", "to", "the", "C0221154#ent", "<e1>", "symptoms", "of", "C3536742#ent", "<e2>", "excess", "in", "pseudopheochromocytoma", "."], "h": {"id": "C0221154", "name": "C0221154#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [27, 28]}}
{"token": ["We", "now", "show", "that", "caffeine", "inhibits", "the", "catalytic", "activity", "both", "ATM", "and", "the", "related", "C0031727#ent", "<e1>", ",", "ATM", "and", "Rad3-related", "(", "C3711837#ent", "<e2>", ")", ",", "at", "drug", "concentrations", "to", "those", "that", "induce", "radiosensitization", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3711837", "name": "C3711837#ent", "pos": [21, 22]}}
{"token": ["Nine", "of", "18", "evaluable", "patients", "responded", "to", "C0026267#ent", "<e1>", "(", "50", "%", ")", "with", "1", "CR", "and", "8", "C1418963#ent", "<e2>", "."], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418963", "name": "C1418963#ent", "pos": [18, 19]}}
{"token": ["When", "considering", "additional", "risk", "factors", "including", "C0035078#ent", "<e1>", "substance", "dependence", "and", "depression", "and/or", "posttraumatic", "stress", "disorder", "C0276240#ent", "<e2>", "remained", "a", "significant", "indicator", ",", "but", "it", "was", "most", "strongly", "associated", "with", "low", "birth", "weight", "women", "also", "experiencing", "depression", "and/or", "posttraumatic", "stress", "disorder"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0276240", "name": "C0276240#ent", "pos": [16, 17]}}
{"token": ["Importantly", ",", "C0011777#ent", "<e1>", "blunted", "IL-17-dependent", "activation", "of", "C0169101#ent", "<e2>", "suggesting", "a", "mechanistic", "relationship", "between", "these", "activities", "and", "the", "aforementioned", "gene", "expression", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [8, 9]}}
{"token": ["[2", "-", "3H]Mannose-labeled", "C0017953#ent", "<e1>", "were", "prepared", "from", "three", "purified", "mod", "A", "C0085078#ent", "<e2>", "compared", "to", "the", "equivalent", "C0017953#ent", "<e1>", "from", "parental", "enzymes", "."], "h": {"id": "C0017953", "name": "C0017953#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [12, 13]}}
{"token": ["The", "overall", "polypeptide", "fold", "C1332420#ent", "<e1>", "is", "similar", "to", "that", "of", "C1413272#ent", "<e2>", "."], "h": {"id": "C1332420", "name": "C1332420#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413272", "name": "C1413272#ent", "pos": [11, 12]}}
{"token": ["The", "oxidation", "of", "C0000503#ent", "<e1>", "to", "SSA", ",", "catalyzed", "by", "both", "of", "these", "C3540772#ent", "<e2>", ",", "is", "coupled", "to", "the", "reduction", "of", "an", "oxoacid", "."], "h": {"id": "C0000503", "name": "C0000503#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "relationship", "between", "C1565306#ent", "<e1>", "activity", "and", "regulation", "of", "the", "C1979930#ent", "<e2>", "MAP", ")", "kinase", "pathway"], "h": {"id": "C1565306", "name": "C1565306#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1979930", "name": "C1979930#ent", "pos": [15, 16]}}
{"token": ["C0027201#ent", "<e1>", "(", "beta4-GT", ")", "is", "a", "C0669365#ent", "<e2>", "expressed", "enzyme", "that", "synthesizes", "the", "beta4-N-acetyllactosamine", "structure", "in", "glycoconjugates", "."], "h": {"id": "C0027201", "name": "C0027201#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [7, 8]}}
{"token": ["C1855995#ent", "<e1>", "L-2-HGA", ")", "is", "an", "autosomal", "recessive", "neurometabolic", "disorder", "by", "psychomotor", "delay", "C0007758#ent", "<e2>", ",", "macrocephaly", "and", "typical", "neuroradiological", "findings", "of", "subcortical", "leucoencephalopathy"], "h": {"id": "C1855995", "name": "C1855995#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [13, 14]}}
{"token": ["The", "amount", "and", "distribution", "of", "the", "welding", "fume", "lung", "contaminants", "was", "measured", "in", "44", "C1854562#ent", "<e1>", "welders", "from", "two", "C0014493#ent", "<e2>", "."], "h": {"id": "C1854562", "name": "C1854562#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014493", "name": "C0014493#ent", "pos": [19, 20]}}
{"token": ["To", "compare", "the", "C0012798#ent", "<e1>", "effect", "of", "coadministration", "of", "C0086140#ent", "<e2>", "and", "flurosemide", "with", "that", "of", "coadministration", "of", "Albumin", "and", "flurosemide", "on", "primary", "nephrotic", "syndrome"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [9, 10]}}
{"token": ["The", "C0017801#ent", "<e1>", "GS", ")", "ranks", "as", "one", "of", "the", "most", "remarkable", "C1142644#ent", "<e2>"], "h": {"id": "C0017801", "name": "C0017801#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}}
{"token": ["Further", ",", "C0872972#ent", "<e1>", "treatment", "significantly", "reduced", "phosphorylation", "of", "C1366894#ent", "<e2>", "FAK", ")", "at", "925Y", ",", "but", "not", "at", "397Y", ",", "suggesting", "a", "specific", "role", "in", "FAK-dependent", "signaling", "."], "h": {"id": "C0872972", "name": "C0872972#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366894", "name": "C1366894#ent", "pos": [9, 10]}}
{"token": ["Neuropathy", "and", "depressed", "ventricular", "function", "characteristic", "of", "pure", "C0039841#ent", "<e1>", "were", "observed", "in", "the", "absence", "of", "high", "cardiac", "output", "C0032617#ent", "<e2>", "the", "pathogenesis", "of", "which", "may", "require", "other", "unknown", "factors", "."], "h": {"id": "C0039841", "name": "C0039841#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032617", "name": "C0032617#ent", "pos": [19, 20]}}
{"token": ["C3810549#ent", "<e1>", "proved", "to", "be", "a", "good", "choice", "for", "treatment", "of", "C0744130#ent", "<e2>", ",", "due", "to", "its", "high", "safety", ",", "can", "be", "successfully", "utilized", "also", "in", "OPAT", "programmes"], "h": {"id": "C3810549", "name": "C3810549#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0744130", "name": "C0744130#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "case", "of", "an", "immunocompetent", "child", "who", "developed", "C0152445#ent", "<e1>", "a", "concurrent", "C0221423#ent", "<e2>", "by", "Cryptosporidium", "parvum"], "h": {"id": "C0152445", "name": "C0152445#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [14, 15]}}
{"token": ["In", "particular", ",", "GnRH", "might", "regulate", "C3536870#ent", "<e1>", "expression", "by", "increasing", "of", "C1623430#ent", "<e2>", "and", "c-fos", "levels", "."], "h": {"id": "C3536870", "name": "C3536870#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [12, 13]}}
{"token": ["The", "C1335631#ent", "<e1>", "ROCK", ")", "isoforms", ",", "C1335632#ent", "<e2>", "and", "ROCK2", ",", "were", "initially", "discovered", "as", "downstream", "targets", "of", "the", "small", "GTP-binding", "protein", "Rho"], "h": {"id": "C1335631", "name": "C1335631#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1335632", "name": "C1335632#ent", "pos": [7, 8]}}
{"token": ["This", "has", "led", "to", "the", "suggestion", "that", "FMR1", "and", "FXR2", "functionally", "overlap", "and", "that", "increasing", "the", "expression", "of", "C1414873#ent", "<e1>", "may", "ameliorate", "the", "symptoms", "of", "an", "C2700049#ent", "<e2>", "deficiency", "."], "h": {"id": "C1414873", "name": "C1414873#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2700049", "name": "C2700049#ent", "pos": [26, 27]}}
{"token": ["The", "C1412365#ent", "<e1>", "patterns", "indicated", "the", "presence", "and", "expression", "of", "C1417679#ent", "<e2>", "from", "both", "parents", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["The", "C0035064#ent", "<e1>", "examined", "were", "ferric", "gluconate", "FeG", ")", ",", "C0060241#ent", "<e2>", "SFO", ")", ",", "iron", "chondroitin", "sulfate", "ICS", ")", "and", "cideferron", "(", "CiF", ")", ",", "which", "were", "used", "as", "intravenous", "medication", "iron", "deficiency", "anemia", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0060241", "name": "C0060241#ent", "pos": [10, 11]}}
{"token": ["This", "model", "revealed", "that", "cortical", "neurons", "undergo", "a", "stretch-induced", "delayed", "depolarization", "(", "C0011854#ent", "<e1>", ")", "of", "their", "resting", "membrane", "potential", "C1412063#ent", "<e2>", ")", "which", "is", "approximately", "10", "mV", "in", "magnitude", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412063", "name": "C1412063#ent", "pos": [20, 21]}}
{"token": ["The", "C0211705#ent", "<e1>", "acting", "on", "C1414295#ent", "<e2>", "is", "an", "unusual", "and", "specific", "one", ",", "whose", "activity", "is", "dependent", "on", "calcium", "ions", "calmodulin", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414295", "name": "C1414295#ent", "pos": [5, 6]}}
{"token": ["A", "sequence", "alignment", "C0059945#ent", "<e1>", "all", "known", "C0088353#ent", "<e2>", "revealed", "six", "highly", "conserved", "motifs", "containing", "residues", "that", "corresponded", "to", "the", "catalytic", "residues", "in", "the", "AP", "endonucleases"], "h": {"id": "C0059945", "name": "C0059945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0088353", "name": "C0088353#ent", "pos": [7, 8]}}
{"token": ["Ketanserine", "and", "methiothepin", ",", "5-HT", "receptor", "antagonists", "did", "partially", "block", "the", "methylenedioxymethamphetamine-induced", "loss", "tryptophan", "hydroxylase", "activity", ",", "suggesting", "a", "possible", "role", "for", "C0243051#ent", "<e1>", "release", "in", "the", "acute", "effects", "the", "C1254351#ent", "<e2>", "on", "enzyme", "activity"], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [30, 31]}}
{"token": ["Health", "departments", "CBOs", "should", "consider", "this", "strategy", "as", "an", "effective", "method", "for", "recruiting", "persons", "for", "C1705553#ent", "<e1>", "and", "identifying", "those", "with", "undiagnosed", "C0019693#ent", "<e2>"], "h": {"id": "C1705553", "name": "C1705553#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [22, 23]}}
{"token": ["Numerous", "carbohydrate", "chains", "characterized", "by", "the", "presence", "of", "the", "C1956346#ent", "<e1>", "(", "Sd(a", ")", ")", "determinant", ",", "including", "respectively", "C3833037#ent", "<e2>", ",", "NeuGc", "or", "Kdn", "as", "a", "sialic", "acid"], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3833037", "name": "C3833037#ent", "pos": [19, 20]}}
{"token": ["One", "isolate", "with", "parasite", "GDH-2", "and", "six", "C1875400#ent", "<e1>", "with", "parasite", "C0236558#ent", "<e2>", "were", "recorded", "from", "chloroquine-resistant", "cases", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0236558", "name": "C0236558#ent", "pos": [11, 12]}}
{"token": ["We", "suggest", "that", "the", "gene", "for", "C1416805#ent", "<e1>", "part", "of", "an", "important", "lipocalin", "superfamily", "C1418864#ent", "<e2>", "chromosome", "9", "band", "q34", "."], "h": {"id": "C1416805", "name": "C1416805#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418864", "name": "C1418864#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "we", "propose", "that", "C1705637#ent", "<e1>", "is", "a", "critical", "regulator", "of", "innate", "immunity", "C0035690#ent", "<e2>", "CNS", "cells", "."], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035690", "name": "C0035690#ent", "pos": [14, 15]}}
{"token": ["This", "C3536890#ent", "<e1>", "the", "other", "proteins", "of", "this", "family", "include", "four", "C1305923#ent", "<e2>", "three", "heavy", "chains", "HC1", ",", "HC2", ",", "HC3", ")", "and", "one", "light", "chain", "bikunin", ")", "."], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [11, 12]}}
{"token": ["This", "C3536890#ent", "<e1>", "PT-1", ",", "was", "composed", "of", "C1305923#ent", "<e2>", "by", "disulfide", "bridge(s", ")", "."], "h": {"id": "C3536890", "name": "C3536890#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}}
{"token": ["Intracranial", "hypertension", "cerebral", "edema", "hydrocephalus", ",", "inflammatory", "diseases", "the", "central", "nervous", "system", "and", "C0007820#ent", "<e1>", "the", "main", "associated", "causes", "in", "deaths", "due", "to", "C0338437#ent", "<e2>", "."], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0338437", "name": "C0338437#ent", "pos": [23, 24]}}
{"token": ["C0007820#ent", "<e1>", "a", "relatively", "common", "but", "under-recognised", "complication", "of", "C0338437#ent", "<e2>", "."], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0338437", "name": "C0338437#ent", "pos": [9, 10]}}
{"token": ["Also", ",", "C0015109#ent", "<e1>", "and", "hexobarbital", ",", "alternate", "substrates", "of", "the", "C0066083#ent", "<e2>", "inhibited", "binding", "."], "h": {"id": "C0015109", "name": "C0015109#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0066083", "name": "C0066083#ent", "pos": [11, 12]}}
{"token": ["This", "report", "and", "review", "of", "the", "literature", "suggest", "that", "epilepsy", "in", "C0024796#ent", "<e1>", "be", "due", "to", "primary", "C0007682#ent", "<e2>", "secondary", "to", "disorders", "of", "connective", "tissue"], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007682", "name": "C0007682#ent", "pos": [17, 18]}}
{"token": ["The", "ability", "of", "TCAH", "to", "cleave", "FasL", "and", "thereby", "decrease", "AICD", "appeared", "to", "be", "mediated", "by", "C1334706#ent", "<e1>", "and", "correlated", "with", "a", "TCAH-induced", "increase", "in", "C0166059#ent", "<e2>"], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0166059", "name": "C0166059#ent", "pos": [25, 26]}}
{"token": ["Recombinant", "protein", "S", "the", "same", "affinity", "for", "Ca2", "+", "as", "C2002622#ent", "<e1>", "plasma", "and", "the", "two", "proteins", "had", "the", "same", "activated", "C1414509#ent", "<e2>", "in", "a", "functional", "assay"], "h": {"id": "C2002622", "name": "C2002622#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414509", "name": "C1414509#ent", "pos": [21, 22]}}
{"token": ["A", "subset", "of", "parathyroid", "adenomas", "a", "clonal", "chromosomal", "rearrangement", "which", "the", "C1413172#ent", "<e1>", "juxtaposed", "to", "the", "upstream", "region", "the", "C1419072#ent", "<e2>", "resulting", "in", "cyclin", "D1", "overexpression", "."], "h": {"id": "C1413172", "name": "C1413172#ent", "pos": [11, 12]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1419072", "name": "C1419072#ent", "pos": [19, 20]}}
{"token": ["Other", "options", "can", "include", "brief", "bed", "rest", "C0242937#ent", "<e1>", "a", "cervical", "collar", "and", ",", "depending", "on", "the", "condition", ",", "C3540727#ent", "<e2>", ",", "local", "injections", "acetaminophen", ",", "and", "moist", "heat"], "h": {"id": "C0242937", "name": "C0242937#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540727", "name": "C3540727#ent", "pos": [19, 20]}}
{"token": ["This", "very", "unusual", "promoter", "structure", "low", ",", "basal", "expression", "of", "C4084757#ent", "<e1>", "and", "the", "recruitment", "of", "C1337106#ent", "<e2>", "to", "the", "GRE", "in", "response", "to", "guanylic", "nucleotide", "limitation", "."], "h": {"id": "C4084757", "name": "C4084757#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1337106", "name": "C1337106#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "neither", "pretreatment", "with", "oral", "aspirin", "C3210186#ent", "<e1>", "affected", "her", "reaction", "to", "C1608295#ent", "<e2>", "."], "h": {"id": "C3210186", "name": "C3210186#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1608295", "name": "C1608295#ent", "pos": [14, 15]}}
{"token": ["Two", "patients", "were", "found", "to", "have", "C0014556#ent", "<e1>", "two", "lateral", "temporal", "lobe", "epilepsy", "eight", "C0085541#ent", "<e2>", "three", "parietal", "lobe", "epilepsy", "one", "occipital", "lobe", "epilepsy"], "h": {"id": "C0014556", "name": "C0014556#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085541", "name": "C0085541#ent", "pos": [14, 15]}}
{"token": ["oxLDL", "also", "elicited", "the", "activation", "of", "C0003993#ent", "<e1>", ",", "nuclear", "factor-kappaB", "and", "cAMP", "response", "element-binding", "protein", "but", "not", "C1333571#ent", "<e2>"], "h": {"id": "C0003993", "name": "C0003993#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [18, 19]}}
{"token": ["C3665349#ent", "<e1>", "is", "frequently", "accompanied", "by", "musculoskeletal", "manifestations", "from", "myalgias", "and", "C0003862#ent", "<e2>", "to", "true", "myopathy", "arthritis", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [11, 12]}}
{"token": ["The", "P/CAF", "protein", "intrinsic", "C0671924#ent", "<e1>", "HAT", ")", "activity", "and", "is", "capable", "of", "binding", "the", "C1425716#ent", "<e2>", "CBP", "."], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425716", "name": "C1425716#ent", "pos": [15, 16]}}
{"token": ["C0072916#ent", "<e1>", "administration", "enhanced", "the", "amplitude", "and", "C2926735#ent", "<e2>", "of", "primary", "peristalsis", "the", "lower", "esophageal", "sphincter", "tone", "which", "reached", "normal", "control", "values"], "h": {"id": "C0072916", "name": "C0072916#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [7, 8]}}
{"token": ["double", "the", "C0003195#ent", "<e1>", "was", "approximately", "the", "same", "as", "that", "of", "C0012702#ent", "<e2>", "at", "2.5", "mg/kg", "(", "half", "the", "C0003195#ent", "<e1>", "."], "h": {"id": "C0012702", "name": "C0012702#ent", "pos": [11, 12]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [2, 3]}}
{"token": ["In", "3", "out", "of", "4", "patients", "studied", ",", "there", "was", "a", "good", "correlation", "between", "the", "lowest", "level", "of", "C0012702#ent", "<e1>", "that", "elicited", "both", "an", "C0003195#ent", "<e2>", "a", "demonstrable", "decrease", "in", "cardiac", "contractility"], "h": {"id": "C0012702", "name": "C0012702#ent", "pos": [18, 19]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [24, 25]}}
{"token": ["The", "availability", "of", "C0012702#ent", "<e1>", "for", "clinical", "use", "1977", "produced", "optimism", "for", "an", "effective", "C0003195#ent", "<e2>", "was", "free", "of", "the", "well-known", "immediate", "and", "late", "toxicities", "quinidine", "and", "procainamide", "."], "h": {"id": "C0012702", "name": "C0012702#ent", "pos": [3, 4]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [14, 15]}}
{"token": ["Isopentenyl", "diphosphate", "(IPP):dimethylallyl", "diphosphate", "(", "DMAPP", ")", "C1334289#ent", "<e1>", "is", "a", "key", "C0014442#ent", "<e2>", "in", "the", "biosynthesis", "of", "isoprenoids", "."], "h": {"id": "C1334289", "name": "C1334289#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}}
{"token": ["C0033770#ent", "<e1>", "NP", "conjugated", "with", "monoclonal", "C1706545#ent", "<e2>", "antibody", "was", "used", "as", "a", "label", "in", "an", "immunorecognition", "event", "."], "h": {"id": "C0033770", "name": "C0033770#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706545", "name": "C1706545#ent", "pos": [6, 7]}}
{"token": ["These", "results", "indicate", "that", "EPA", "and", "C3539567#ent", "<e1>", "have", "different", "effects", "on", "the", "modulation", "of", "C1563761#ent", "<e2>"], "h": {"id": "C3539567", "name": "C3539567#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1563761", "name": "C1563761#ent", "pos": [15, 16]}}
{"token": ["Additionally", ",", "the", "escalation", "of", "C3642475#ent", "<e1>", "probably", "connected", "with", "bigger", "air", "pollution", "frequent", "C1828863#ent", "<e2>", "sneezing", ",", "nasal", "stuffing", "is", "observed", "in", "areas", "of", "intensive", "traffic", "noise", "."], "h": {"id": "C3642475", "name": "C3642475#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1828863", "name": "C1828863#ent", "pos": [14, 15]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "this", "pilus", "type", "pyelonephritis-associated", "pili", ",", "C1423108#ent", "<e2>", ")", "and", "those", "encoding", "type", "1", "pili", "been", "cloned", "from", "a", "urinary", "tract", "infection", "isolate", "of", "E.", "coli", "transferred", "to", "an", "E.", "coli", "K-12", "derivative", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [10, 11]}}
{"token": ["Another", "clone", "(", "S-13", ")", "with", "only", "five", "substitutions", "in", "C0013570#ent", "<e1>", "62", "spread", "slightly", "faster", "than", "C1706319#ent", "<e2>", "-", "01", "but", "not", "as", "effectively", "as", "P-Oka", "."], "h": {"id": "C0013570", "name": "C0013570#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706319", "name": "C1706319#ent", "pos": [17, 18]}}
{"token": ["Elevated", "levels", "of", "CHI3L1", "(", "chitinase-3-like", "protein", "1", "are", "associated", "with", "disorders", "exhibiting", "increased", "connective", "tissue", ",", "such", "as", "C0038013#ent", "<e1>", "osteoarthritis", ",", "scleroderma", ",", "and", "C1623038#ent", "<e2>", "of", "the", "liver", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [26, 27]}}
{"token": ["Finally", ",", "electrophysiological", "and", "histological", "findings", "are", "reported", "in", "some", "patients", "with", "neuropathy", "associated", "with", "malignant", "neoplasm", "with", "C0038013#ent", "<e1>", "with", "polyarteritis", "nodosa", "with", "acute", "intermittent", "porphyria", "with", "C1623038#ent", "<e2>", "of", "the", "liver", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [28, 29]}}
{"token": ["C0524620#ent", "<e1>", "directly", "linked", "to", "the", "presence", "of", "C0028754#ent", "<e2>", "which", "indicates", "insulin", "resistance", "lies", "at", "the", "root", "of", "all", "risk", "factors", "early", "indications", "of", "type", "2", "diabetes"], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [8, 9]}}
{"token": ["Both", "Akt2", "and", "C0285558#ent", "<e1>", "associated", "in", "complexes", "with", "C4084905#ent", "<e2>", ",", "but", "only", "Akt2", "inhibited", "C4084905#ent", "<e2>", "in", "kinase", "assays", ",", "suggesting", "an", "underlying", "molecular", "basis", "the", "different", "cellular", "phenotypes", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4084905", "name": "C4084905#ent", "pos": [9, 10]}}
{"token": ["This", "feature", "deserves", "attention", "because", ",", "as", "a", "rule", ",", "the", "presence", "of", "an", "C0039082#ent", "<e1>", "the", "prognosis", "of", "C1705360#ent", "<e2>", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [19, 20]}}
{"token": ["The", "results", "suggest", "the", "possibility", "of", "a", "common", "C0079429#ent", "<e1>", "in", "the", "MHC", "for", "both", "tuberculosis", "and", "C0023343#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [17, 18]}}
{"token": ["The", "B", "chain", "C-1r", "contains", "the", "catalytic", "portion", "the", "C0014442#ent", "<e1>", "and", "is", "homologous", "to", "the", "trypsin", "family", "of", "C2717971#ent", "<e2>"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [19, 20]}}
{"token": ["In", "chloroplasts", ",", "the", "homolog", "of", "C1420408#ent", "<e1>", "was", "found", "to", "bind", "a", "C1415068#ent", "<e2>", "cpSRP43", ")", "rather", "than", "to", "an", "RNA", "."], "h": {"id": "C1420408", "name": "C1420408#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415068", "name": "C1415068#ent", "pos": [13, 14]}}
{"token": ["Many", "reports", "have", "demonstrated", "that", "the", "C0289779#ent", "<e1>", "has", "the", "good", "hypoglycemic", "effect", "monotherapy", "and", "in", "combination", "therapy", "C3653359#ent", "<e2>", ",", "metformin", ",", "alpha-glucosidase", "inhibitors", "or", "insulin", "."], "h": {"id": "C0289779", "name": "C0289779#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3653359", "name": "C3653359#ent", "pos": [18, 19]}}
{"token": ["The", "sustained", "release", "of", "the", "active", "compound", "C0042523#ent", "<e1>", "retard", "is", "obtained", "by", "mixing", "and", "pressing", "verapamil", "hydrochloride", "C0142791#ent", "<e2>"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0142791", "name": "C0142791#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "report", "that", "ER", "stress-induced", "C3537312#ent", "<e1>", "requires", "the", "activation", "of", "C1259877#ent", "<e2>", "PKC", ")", ",", "a", "member", "of", "the", "novel-type", "PKC", "family", "."], "h": {"id": "C3537312", "name": "C3537312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}}
{"token": ["BRCA1", "silencing", "by", "siRNA", "was", "used", "to", "investigate", "the", "effect", "of", "C0376571#ent", "<e1>", "mutations", "on", "C1334089#ent", "<e2>", "expression", "."], "h": {"id": "C0376571", "name": "C0376571#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [15, 16]}}
{"token": ["Transient", "transfection", "experiments", "using", "C0376571#ent", "<e1>", "promoter-luciferase", "reporter", "constructs", "reveal", "that", "C1334089#ent", "<e2>", "enhances", "C0376571#ent", "<e1>", "promoter", "activity", "suggesting", "that", "the", "effect", "of", "C1334089#ent", "<e2>", "is", "mediated", "at", "the", "transcriptional", "level", "."], "h": {"id": "C0376571", "name": "C0376571#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [11, 12]}}
{"token": ["In", "150", "patients", "with", "different", "C0018567#ent", "<e1>", "and", "15", "controls", "the", "activity", "of", "C0162745#ent", "<e2>", "serum", "was", "determined", "."], "h": {"id": "C0018567", "name": "C0018567#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [13, 14]}}
{"token": ["Overexpression", "of", "C1705438#ent", "<e1>", "was", "associated", "with", "strong", "alteration", "in", "lipid", "metabolism", "and", "C1420398#ent", "<e2>", "was", "identified", "as", "a", "candidate", "transcription", "factor", "for", "lipogenic", "enzyme", "induction", "."], "h": {"id": "C1705438", "name": "C1705438#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420398", "name": "C1420398#ent", "pos": [13, 14]}}
{"token": ["About", "10", "years", "known", "are", "the", "RET", "gene", "susceptible", "for", "multiple", "endocrine", "neoplasia", "type", "2", "the", "VHL", "gene", "C0019562#ent", "<e1>", "and", "the", "C0085114#ent", "<e2>", "neurofibromatosis", "Recklinghausen", "neuro-", "fibromatosis", "type", "1", "."], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0085114", "name": "C0085114#ent", "pos": [22, 23]}}
{"token": ["These", "studies", "demonstrate", "that", "C2826076#ent", "<e1>", "effective", "in", "the", "treatment", "of", "C0008533#ent", "<e2>", "has", "the", "safety", "profile", "expected", "from", "a", "product", "prepared", "by", "recombinant", "technology"], "h": {"id": "C2826076", "name": "C2826076#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [11, 12]}}
{"token": ["It", "has", "now", "been", "3", "years", "since", "the", "von", "Willebrand", "factor", "protease", "implicated", "in", "thrombocytopenic", "purpura", "TTP", ")", "pathogenesis", "was", "identified", "as", "C1413036#ent", "<e1>", "(", "a", "disintegrin-like", "and", "C1418385#ent", "<e2>", "with", "thrombospondin", "type", "1", "motif", "13", "."], "h": {"id": "C1413036", "name": "C1413036#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1418385", "name": "C1418385#ent", "pos": [28, 29]}}
{"token": ["Thus", ",", "our", "results", "show", "that", "there", "is", "an", "age-dependent", "regulation", "of", "NMDAR", "subunits", "C1538051#ent", "<e1>", "and", "NR2A", ",", "but", "not", "NR2B", ",", "in", "C1706578#ent", "<e2>", "+", "/-", "mice", "."], "h": {"id": "C1538051", "name": "C1538051#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706578", "name": "C1706578#ent", "pos": [24, 25]}}
{"token": ["The", "inability", "of", "extracts", "of", "C3272498#ent", "<e1>", "and", "me-6", "mutants", "to", "form", "C0268618#ent", "<e2>", "that", "has", "been", "previously", "reported", "is", "due", "to", "the", "absence", "of", "N(5)-methyltetrahydrofolate", "from", "these", "preparations", "."], "h": {"id": "C3272498", "name": "C3272498#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268618", "name": "C0268618#ent", "pos": [12, 13]}}
{"token": ["When", "expressed", "by", "transfection", "in", "cultured", "cell", "lines", "this", "gene", "determines", "expression", "of", "a", "C0016790#ent", "<e1>", "capable", "of", "efficiently", "utilizing", "N-acetyllactosamine", "to", "form", "the", "C1429589#ent", "<e2>", "Gal", "beta", "1", "---4[Fuc", "alpha", "1", "---3]GlcNAc", ")", "."], "h": {"id": "C0016790", "name": "C0016790#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1429589", "name": "C1429589#ent", "pos": [24, 25]}}
{"token": ["The", "osmoprotective", "derivatives", "of", "phosphorylcholine", "which", "induce", "the", "synthesis", "of", "C0031669#ent", "<e1>", "in", "P.", "aeruginosa", "choline", ",", "glycine", "betaine", "and", "C0058265#ent", "<e2>", ",", "but", "not", "sarcosine", "(", "monomethylglycine", ")", "or", "glycine", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0058265", "name": "C0058265#ent", "pos": [20, 21]}}
{"token": ["The", "cDNA", "encoding", "zebrafish", "mitochondrial", "C3538858#ent", "<e1>", "was", "cloned", ",", "C3889446#ent", "<e2>", "in", "Escherichia", "coli", "and", "purified", "with", "a", "three-step", "purification", "protocol", "."], "h": {"id": "C3538858", "name": "C3538858#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}}
{"token": ["The", "concentrations", "of", "zinc", ",", "cadmium", ",", "copper", ",", "lead", ",", "magnesium", ",", "and", "C2936886#ent", "<e1>", "were", "determined", "in", "liver", ",", "kidney", "cortex", "and", "C0771711#ent", "<e2>", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [24, 25]}}
{"token": ["Lysyl", "oxidase", "C0024375#ent", "<e1>", ")", "is", "an", "extracellular", "matrix", "ECM", ")", "C0027203#ent", "<e2>", "that", "catalyzes", "the", "cross-linking", "of", "collagens", "or", "elastin", "in", "the", "extracellular", "compartment", "thereby", "regulating", "the", "tensile", "strength", "tissues", "."], "h": {"id": "C0024375", "name": "C0024375#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}}
{"token": ["C1334043#ent", "<e1>", "YPF", "and", "yeast", "actin", "HPF1", "and", "C0231528#ent", "<e2>", "bound", "more", "tightly", "to", "one", "another", "than", "heterologous", "pairs", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0231528", "name": "C0231528#ent", "pos": [8, 9]}}
{"token": ["Syndromic", "MCDs", "with", "CNS", "involvement", "include", "mitochondrial", "encephalomyopathy", "lactacidosis", ",", "stroke-like", "episodes", "syndrome", ",", "myoclonic", "epilepsy", "ragged", "red", "fibers", "syndrome", "mitochondrial", "neuro-gastrointestinal", "encephalomyopathy", "syndrome", "neurogenic", "muscle", "weakness", "C0004134#ent", "<e1>", ",", "and", "retinitis", "pigmentosa", "syndrome", "mitochondrial", "depletion", "syndrome", "Kearns-Sayre", "syndrome", "and", "C0023264#ent", "<e2>", "Leber's", "hereditary", "optic", "neuropathy", "Friedreich's", "ataxia", "and", "multiple", "systemic", "lipomatosis"], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [27, 28]}, "relation": "manifestation_of", "t": {"id": "C0023264", "name": "C0023264#ent", "pos": [40, 41]}}
{"token": ["The", "present", "study", "evaluates", "the", "efficacy", "of", "C0051150#ent", "<e1>", "in", "a", "group", "of", "the", "patients", "with", "C0242453#ent", "<e2>", "."], "h": {"id": "C0051150", "name": "C0051150#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242453", "name": "C0242453#ent", "pos": [16, 17]}}
{"token": ["Although", "the", "insulin-induced", "GLUT4", "translocation", "in", "adipocytes", "was", "not", "affected", "by", "the", "C1705969#ent", "<e1>", "treatment", ",", "the", "3-O-methy-D-glucose", "flux", "C4082284#ent", "<e2>", "adipocytes", "of", "Cd-treated", "rat", "was", "drastically", "reduced", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [19, 20]}}
{"token": ["These", "results", "indicate", "that", "C0022860#ent", "<e1>", ",", "the", "arylethanolamine", ",", "acts", "as", "a", "partial", "C2987634#ent", "<e2>", "on", "beta3-adrenoceptors", "in", "the", "guinea-pig", "gastric", "fundus"], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}}
{"token": ["The", "thresholds", "to", "evoke", "paresthesia", "in", "the", "NSP", "and", "C0028850#ent", "<e1>", "patients", "were", "significantly", "lower", "than", "the", "thresholds", "in", "the", "C1537379#ent", "<e2>", "patients", "."], "h": {"id": "C0028850", "name": "C0028850#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1537379", "name": "C1537379#ent", "pos": [20, 21]}}
{"token": ["The", "method", "is", "illustrated", "by", "the", "analysis", "of", "purified", "C0001022#ent", "<e1>", "is", "applied", "to", "the", "analysis", "of", "biotin", "C3541394#ent", "<e2>", "in", "isolated", "rat", "liver", "mitochondria", "."], "h": {"id": "C0001022", "name": "C0001022#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}}
{"token": ["Assays", "for", "ATP-citrate", "lyase", "C0001022#ent", "<e1>", "and", "fatty", "acid", "synthetase", "that", "all", "three", "C3541394#ent", "<e2>", "were", "associated", "together", "as", "a", "high-molecular-weight", "complex", "that", "under", "low-lipogenic", "conditions", "the", "level", "of", "these", "C3541394#ent", "<e2>", "decreased", "."], "h": {"id": "C0001022", "name": "C0001022#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["Glutamate", "dehydrogenase", "C1415113#ent", "<e1>", ")", "is", "an", "C0014442#ent", "<e2>", "the", "glutamate", "and", "energy", "metabolism", "the", "cell", "."], "h": {"id": "C1415113", "name": "C1415113#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["Nicotine", "altered", "hepatic", "function", "evident", "by", "increased", "C1826354#ent", "<e1>", "and", "GST", "levels", "and", "decreased", "SOD", ",", "C0007367#ent", "<e2>", "and", "GPx", "activities", "."], "h": {"id": "C1826354", "name": "C1826354#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [16, 17]}}
{"token": ["Antipsychotic", "exposure", "produce", "C0234133#ent", "<e1>", "the", "neonate", "and", "lithium", "has", "been", "associated", "with", "C0456013#ent", "<e2>", "lethargy", ",", "flaccidity", ",", "and", "non-toxic", "goiter"], "h": {"id": "C0234133", "name": "C0234133#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0456013", "name": "C0456013#ent", "pos": [13, 14]}}
{"token": ["The", "mouse", "neuronal", "F3", "glycoprotein", "and", "its", "chicken", "homolog", "C1414498#ent", "<e1>", "belong", "to", "a", "subclass", "of", "C0086376#ent", "<e2>", "of", "the", "immunoglobulin", "superfamily", "preferential", "localization", "on", "axons", "and", "neurites", "."], "h": {"id": "C1414498", "name": "C1414498#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}}
{"token": ["It", "produces", "three", "types", "of", "fusion", "gene", "in", "part", "by", "SS18", "from", "chromosome", "18", "by", "SSX1", ",", "C3273639#ent", "<e1>", "or", ",", "rarely", ",", "C1420437#ent", "<e2>", "from", "the", "X", "chromosome"], "h": {"id": "C3273639", "name": "C3273639#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420437", "name": "C1420437#ent", "pos": [23, 24]}}
{"token": ["We", "studied", "expression", "of", "collagenase", "gene", "stromelysin", "gene", "skin", "fibroblasts", "from", "patients", "with", "recessive", "dystrophic", "epidermolysis", "bullosa", "C0079474#ent", "<e1>", ")", "and", "dominant", "C0079294#ent", "<e2>", "DDEB", ")", "."], "h": {"id": "C0079474", "name": "C0079474#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0079294", "name": "C0079294#ent", "pos": [22, 23]}}
{"token": ["Pretreatment", "serum", "levels", "the", "antigens", "CA-125", ",", "tissue", "polypeptide", "Antigen", "C0032143#ent", "<e1>", ")", ",", "carcinoembryonic", "antigen", "CEA", ")", ",", "and", "placental", "alkaline", "phosphatase", "C1418627#ent", "<e2>", ")", "were", "determined", "in", "samples", "from", "295", "women", "with", "adnexal", "masses"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418627", "name": "C1418627#ent", "pos": [23, 24]}}
{"token": ["This", "C0079429#ent", "<e1>", "is", "now", "designated", "C1412527#ent", "<e2>", "by", "HUGO", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412527", "name": "C1412527#ent", "pos": [6, 7]}}
{"token": ["Dual", "infection", "TTV", "with", "either", "C0019163#ent", "<e1>", "or", "HCV", "did", "not", "affect", "the", "ALT", "levels", "of", "C0019158#ent", "<e2>", "patients", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [16, 17]}}
{"token": ["Data", "obtained", "concerning", "C0019163#ent", "<e1>", "a", "possible", "couse", "of", "Down's", "syndrome", "neonatal", "C0019158#ent", "<e2>", ",", "and", "the", "occurrence", "of", "Hepatitis", "A", "B", "in", "institutionalized", "Down's", "syndrome", "matched", "non-Down's", "syndrome", "retarded", "patients", "was", "summarized", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [12, 13]}}
{"token": ["We", "report", "the", "case", "of", "a", "patient", "who", "developed", "C0013927#ent", "<e1>", "was", "effectively", "managed", "with", "aprotinin", "to", "control", "the", "C0005779#ent", "<e2>", "associated", "with", "devastating", "complication", "of", "pregnancy", "."], "h": {"id": "C0013927", "name": "C0013927#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [19, 20]}}
{"token": ["Folates", "are", "essential", "for", "life", "and", "C0016412#ent", "<e1>", "to", "a", "host", "of", "health", "problems", "cardiovascular", "disease", "fetal", "abnormalities", "C0042075#ent", "<e2>", "and", "cancer", "."], "h": {"id": "C0016412", "name": "C0016412#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [18, 19]}}
{"token": ["Evaluation", "of", "the", "clinical", "and", "histological", "signs", "of", "C1610605#ent", "<e1>", "in", "7", "patients", "treated", "with", "C0010592#ent", "<e2>", "A", "was", "based", "on", "a", "follow-up", "of", "100", "days", "after", "bone", "marrow", "transplantation"], "h": {"id": "C1610605", "name": "C1610605#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [15, 16]}}
{"token": ["Mutations", "in", "the", "Leucine-Rich", "Repeat", "Kinase", "2", "gene", "C1425650#ent", "<e1>", ")", "are", "mainly", "responsible", "for", "C0030567#ent", "<e2>", "PD", ")", "with", "either", "a", "dominant", "pattern", "of", "transmission", "or", "a", "sporadic", "occurrence", "due", "to", "the", "reduced", "penetrance", "."], "h": {"id": "C1425650", "name": "C1425650#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [15, 16]}}
{"token": ["The", "persistent", "effect", "of", "chronic", "C0171023#ent", "<e1>", "administration", "on", "C1422070#ent", "<e2>", "sensitization", "may", "be", "relevant", "to", "the", "chronic", "therapeutic", "efficacy", "atypical", "antipsychotics", "treating", "schizophrenia-a", "clinical", "syndrome", "to", "enhanced", "sensitivity", "to", "N-methyl-d-aspartate", "(NMDA)-receptor", "antagonists", "."], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [9, 10]}}
{"token": ["One", "of", "the", "most", "important", "question", "in", "the", "revascularization", "of", "patients", "with", "impaired", "left", "ventricular", "function", "by", "C1956346#ent", "<e1>", "the", "proper", "differentiation", "of", "C0027051#ent", "<e2>", "the", "region", "with", "the", "possibility", "of", "functional", "recovery", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [17, 18]}, "relation": "related_to", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "a", "direct", ",", "and", "possibly", "irreversible", ",", "interaction", "of", "C0242430#ent", "<e1>", "with", "the", "dopamine-binding", "component", "of", "the", "C0001492#ent", "<e2>"], "h": {"id": "C0242430", "name": "C0242430#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [20, 21]}}
{"token": ["Northern", "blot", "analysis", "specific", "expression", "in", "the", "testis", "of", "this", "C0017337#ent", "<e1>", ",", "which", "we", "named", "the", "C3812474#ent", "<e2>", "SGRG", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3812474", "name": "C3812474#ent", "pos": [17, 18]}}
{"token": ["C0265255#ent", "<e1>", "TRPS", ")", "is", "a", "rare", "C0037274#ent", "<e2>", "with", "growth", "retardation", "craniofacial", "abnormalities", "alopecia", "and", "brachyphalangia", "."], "h": {"id": "C0265255", "name": "C0265255#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [7, 8]}}
{"token": ["Ten", "cases", "of", "C1418941#ent", "<e1>", "been", "associated", "with", "use", "of", "GH", "purified", "from", "C0032002#ent", "<e2>", "in", "the", "USA", ",", "and", "more", "cases", "may", "appear", "in", "the", "future", "."], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [13, 14]}}
{"token": ["I", "found", "31", "reports", "of", "C0541746#ent", "<e1>", ";", "12", "of", "them", "examined", "low-dose", "regimens", ",", "i.e.", ",", "<", "or", "=", "25", "mg/day", "of", "C0020261#ent", "<e2>", "or", "its", "equivalent", "in", "other", "C0541746#ent", "<e1>", "."], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [23, 24]}, "relation": "has_structural_class", "t": {"id": "C0541746", "name": "C0541746#ent", "pos": [5, 6]}}
{"token": ["Acquired", "mutations", "been", "identified", "in", "the", "oncogenes", "C1537502#ent", "<e1>", "and", "HER2/neu", ",", "and", "in", "the", "tumor", "suppressor", "genes", "p16", "p53", ",", "C0694891#ent", "<e2>", ",", "and", "BRCA2", "."], "h": {"id": "C1537502", "name": "C1537502#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0694891", "name": "C0694891#ent", "pos": [21, 22]}}
{"token": ["All", "cases", "responded", "well", "to", "medical", "treatment", "including", "C0034665#ent", "<e1>", ",", "sucralfate", ",", "omeprazole", ",", "C0072916#ent", "<e2>", ",", "and", "octreotide", "."], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [15, 16]}}
{"token": ["It", "may", "be", "concluded", "that", "olsalazine", "resembled", "C2239905#ent", "<e1>", "with", "regard", "to", "the", "inhibition", "of", "the", "C0023837#ent", "<e2>", "but", "had", "effects", "intermediate", "the", "other", "salicylates", "on", "cyclooxygenase", "."], "h": {"id": "C2239905", "name": "C2239905#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [16, 17]}}
{"token": ["C0036078#ent", "<e1>", "was", "discontinued", "and", "the", "patient", "was", "treated", "with", "5-aminosalicylic", "acid", "preparation", "C4083158#ent", "<e2>", ")", "in", "the", "form", "of", "an", "enema", "."], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4083158", "name": "C4083158#ent", "pos": [13, 14]}}
{"token": ["To", "elucidate", "the", "mechanism", "of", "C0011881#ent", "<e1>", "we", "focus", "on", "the", "role", "of", "a", "vitamin", "K-dependent", "growth", "factor", "growth", "arrest-specific", "gene", "6", "C3539526#ent", "<e2>", ")", ",", "and", "its", "receptor", "Axl", "in", "the", "pathogenesis", "of", "C0011881#ent", "<e1>"], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539526", "name": "C3539526#ent", "pos": [22, 23]}}
{"token": ["Consequently", ",", "it", "is", "important", "to", "screen", "for", "C0151721#ent", "<e1>", "in", "men", "who", "fail", "C1318700#ent", "<e2>"], "h": {"id": "C0151721", "name": "C0151721#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1318700", "name": "C1318700#ent", "pos": [14, 15]}}
{"token": ["This", "association", "was", "unrelated", "to", "the", "age", "of", "the", "subjects", "or", "controls", ",", "or", "to", "C0052201#ent", "<e1>", "alleles", "of", "the", "C1412481#ent", "<e2>"], "h": {"id": "C0052201", "name": "C0052201#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [20, 21]}}
{"token": ["The", "C0052201#ent", "<e1>", "e4", ")", "allele", "of", "the", "apolipoprotein", "E", "C1412481#ent", "<e2>", ")", "gene", "has", "been", "implicated", "as", "a", "major", "risk", "factor", "this", "process", "."], "h": {"id": "C0052201", "name": "C0052201#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [10, 11]}}
{"token": ["Human", "C1412364#ent", "<e1>", "ortho-phosphoric", "monoester", "phosphohydrolase", "alkaline", "optimum", ")", ",", "C2932888#ent", "<e2>", "was", "purified", ",", "and", "some", "of", "its", "physical", "and", "chemical", "properties", "examined", "and", "compared", "to", "those", "of", "human", "placental", "alkaline", "phosphatase"], "h": {"id": "C1412364", "name": "C1412364#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2932888", "name": "C2932888#ent", "pos": [10, 11]}}
{"token": ["The", "21,000-dalton", "protein", "(", "p21", ")", "encoded", "by", "the", "ras", "oncogene", "of", "Harvey", "murine", "sarcoma", "virus", "C1336923#ent", "<e1>", ")", "becomes", "phosphorylated", "(", "C1420626#ent", "<e2>", ")", "in", "vivo", "in", "vitro", "threonine", "residue", "59", "."], "h": {"id": "C1336923", "name": "C1336923#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [22, 23]}}
{"token": ["The", "same", "mutation", "in", "a", "C1336923#ent", "<e1>", "reduces", "the", "affinity", "of", "C1420626#ent", "<e2>", "for", "guanine", "nucleotides", "L.A.", "Feig", ",", "B.", "Pan", ",", "T.M.", "Roberts", ",", "and", "G.M.", "Cooper", ",", "Proc", "."], "h": {"id": "C1336923", "name": "C1336923#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [11, 12]}}
{"token": ["The", "frequency", "of", "apoptotic", "nuclear", "profiles", ",", "which", "was", "as", "much", "as", "ten-fold", "higher", "at", "C1424742#ent", "<e1>", "vs.", "E17", ",", "did", "not", "correlate", "anatomically", "with", "C1412932#ent", "<e2>", "or", "C4", "mRNA", "levels", "."], "h": {"id": "C1424742", "name": "C1424742#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412932", "name": "C1412932#ent", "pos": [25, 26]}}
{"token": ["The", "efficacy", "of", "C0022860#ent", "<e1>", "in", "lowering", "blood", "pressure", "assessed", "in", "18", "patients", "with", "C0022661#ent", "<e2>", "hypertension", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [14, 15]}}
{"token": ["Yeast", "two-hybrid", "assays", "that", "C3812755#ent", "<e1>", "interacts", "only", "with", "the", "C0003873#ent", "<e2>", "but", "not", "any", "other", "identifiable", "domains", "of", "Cdc35", "."], "h": {"id": "C3812755", "name": "C3812755#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}}
{"token": ["The", "presence", "of", "C1705592#ent", "<e1>", "was", "not", "restricted", "to", "central", "nervous", "system", "tumors", "2", "of", "2", "C0025297#ent", "<e2>", "5", "of", "5", "acute", "viral", "meningitis", "patients", "contained", "considerable", "C1705592#ent", "<e1>", "levels", "in", "the", "cerebrospinal", "fluid"], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [3, 4]}}
{"token": ["Mild", "hypothermia", "has", "been", "applied", "with", "varying", "degrees", "of", "success", "in", "many", "neurologic", "emergencies", "including", "traumatic", "brain", "injury", "spinal", "cord", "injury", "ischemic", "stroke", "C0038525#ent", "<e1>", "out-of-hospital", "cardiopulmonary", "arrest", "hepatic", "encephalopathy", "perinatal", "asphyxia", "hypoxic-anoxic", "encephalopathy", ",", "and", "infantile", "C0085584#ent", "<e2>"], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [37, 38]}}
{"token": ["Taken", "together", ",", "it", "was", "concluded", "that", "during", "skeletal", "muscle", "cell", "differentiation", "C2985443#ent", "<e1>", "plays", "a", "direct", "role", "in", "activating", "HB-EGF", "gene", "and", "that", "C1704816#ent", "<e2>", "expressed", "preferentially", "in", "myotubes", "and", "in", "its", "membrane-anchored", "form", "."], "h": {"id": "C2985443", "name": "C2985443#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704816", "name": "C1704816#ent", "pos": [24, 25]}}
{"token": ["However", ",", "no", "direct", "effect", "of", "C0010648#ent", "<e1>", "on", "the", "C0024544#ent", "<e2>", "found", "."], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [10, 11]}}
{"token": ["This", "study", "compared", "the", "efficacy", "and", "safety", "of", "pravastatin", "and", "C1567533#ent", "<e1>", "in", "the", "treatment", "of", "C0020443#ent", "<e2>"], "h": {"id": "C1567533", "name": "C1567533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [16, 17]}}
{"token": ["Serum", "levels", "of", "sIL-2R", "can", "be", "used", "to", "monitor", "in", "vivo", "immune", "activation", "its", "elevation", "have", "been", "shown", "to", "be", "correlated", "with", "T", "cell", "immune", "disease", "as", "atopic", "dermatitis", "C1419789#ent", "<e1>", ",", "lymphoma", "and", "C0036421#ent", "<e2>"], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [34, 35]}}
{"token": ["The", "relationship", "between", "mean", "platelet", "volume", "MPV", ")", "and", "platelet", "count", "evaluated", "in", "259", "patients", "with", "C0038013#ent", "<e1>", "311", "patients", "with", "various", "C0018939#ent", "<e2>"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [22, 23]}}
{"token": ["The", "St.", "Thomas", "mixed", "hyperlipidaemic", "(", "SMHL", ")", "rabbit", "exhibits", "an", "inherited", "C0020473#ent", "<e1>", "similar", "to", "that", "seen", "in", "familial", "combined", "hyperlipidaemia", "C1706445#ent", "<e2>", ")", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1706445", "name": "C1706445#ent", "pos": [22, 23]}}
{"token": ["Perhaps", "the", "most", "extensively", "characterized", "genomic", "region", "to", "rearrangement", "is", "17p12", ",", "which", "is", "associated", "with", "C0031117#ent", "<e1>", "hereditary", "neuropathy", "liability", "to", "pressure", "palsies", "HNPP", ")", "and", "Charcot-Marie-Tooth", "disease", "type", "1A", "C0270911#ent", "<e2>", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [31, 32]}}
{"token": ["Perhaps", "the", "most", "extensively", "characterized", "genomic", "region", "to", "rearrangement", "is", "17p12", ",", "which", "is", "associated", "with", "C0031117#ent", "<e1>", "hereditary", "neuropathy", "liability", "to", "pressure", "palsies", "HNPP", ")", "and", "C0270911#ent", "<e2>", "CMT1A;ref", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [27, 28]}}
{"token": ["C0068367#ent", "<e1>", ",", "a", "member", "of", "a", "new", "class", "of", "C0003308#ent", "<e2>", "the", "allylamines", ",", "was", "evaluated", "for", "the", "treatment", "of", "cutaneous", "candidiasis"], "h": {"id": "C0068367", "name": "C0068367#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [10, 11]}}
{"token": ["In", "order", "to", "identify", "the", "putative", "sequence", "motif", ",", "the", "antimicrobial", "activity", "hipposin", "fragments", "20", "different", "bacteria", "was", "compared", "to", "the", "activity", "of", "C1447694#ent", "<e1>", ",", "parasin", "and", "C0006359#ent", "<e2>"], "h": {"id": "C1447694", "name": "C1447694#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0006359", "name": "C0006359#ent", "pos": [28, 29]}}
{"token": ["Our", "knowledge", "of", "C0850666#ent", "<e1>", "that", "it", "is", "possible", "to", "eliminate", "C0030920#ent", "<e2>", "improve", "quality", "of", "life", "ulcer", "patients", "."], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [11, 12]}}
{"token": ["These", "are", "well", "validated", "in", "nonresected", "patients", "before", "and", "after", "treatment", "of", "C0850666#ent", "<e1>", "not", "in", "patients", "with", "partial", "gastric", "resection", "to", "C0030920#ent", "<e2>"], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [22, 23]}}
{"token": ["These", "developmental", "changes", "during", "in", "vitro", "myogenesis", "for", "alpha", "1-ACT", "and", "beta", "APP", "both", "serine", "protease", "inhibitors", "reinforce", "the", "hypothesis", "that", "regulation", "of", "the", "C0036734#ent", "<e1>", "serine", "protease", "inhibitors", "an", "important", "role", "in", "C1417683#ent", "<e2>"], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1417683", "name": "C1417683#ent", "pos": [33, 34]}}
{"token": ["Human", "chorionic", "membrane", "and", "human", "C1571454#ent", "<e1>", "substances", "with", "the", "same", "elution", "volume", "as", "hypothalamic", "TRF", "C3469921#ent", "<e2>", "standards", "during", "separation", "by", "carboxyl-methyl-cellulose", "ion-exchange", "chromatography"], "h": {"id": "C1571454", "name": "C1571454#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3469921", "name": "C3469921#ent", "pos": [16, 17]}}
{"token": ["This", "new", "information", "revealed", "OS", "is", "a", "distinct", "inflammatory", "process", "can", "be", "associated", "with", "C1516876#ent", "<e1>", "diverse", "leaky", "C0085110#ent", "<e2>", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085110", "name": "C0085110#ent", "pos": [18, 19]}}
{"token": ["We", "could", "not", "find", "overt", "relationships", "between", "C2931384#ent", "<e1>", "diseases", "of", "head", "and", "neck", "like", "C0040425#ent", "<e2>", "."], "h": {"id": "C2931384", "name": "C2931384#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040425", "name": "C0040425#ent", "pos": [15, 16]}}
{"token": ["These", "findings", "predicted", "that", "the", "resulting", "C0029016#ent", "<e1>", "would", "code", "for", "a", "structurally", "altered", "C0080058#ent", "<e2>", "valine", "instead", "of", "glycine", "as", "its", "12th", "amino", "acid", "residue"], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [14, 15]}}
{"token": ["Urinary", "levels", "trans", ",", "trans-muconic", "acid", "and", "of", "phenol", ",", "C0054858#ent", "<e1>", "and", "hydroquinone", "(", "free", "and", "conjugated", "with", "C0038719#ent", "<e2>", "and", "glucuronic", "group", "were", "measured", "by", "high-performance", "liquid", "chromatography", "HPLC", ")", "."], "h": {"id": "C0054858", "name": "C0054858#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038719", "name": "C0038719#ent", "pos": [19, 20]}}
{"token": ["CCL17", "was", "specific", "for", "the", "classic", "C1453952#ent", "<e1>", "subtypes", ",", "whereas", "C1332685#ent", "<e2>", "also", "had", "low", "signals", "in", "NLP", "samples", ",", "as", "well", "as", "in", "some", "non-HL", "."], "h": {"id": "C1453952", "name": "C1453952#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332685", "name": "C1332685#ent", "pos": [11, 12]}}
{"token": ["Both", "were", "shown", "to", "be", "mutations", "of", "the", "Ush1c", "gene", "the", "mouse", "ortholog", "of", "the", "gene", "responsible", "for", "human", "C1568247#ent", "<e1>", "for", "the", "non-syndromic", "deafness", "disorder", "C4283800#ent", "<e2>", "."], "h": {"id": "C1568247", "name": "C1568247#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4283800", "name": "C4283800#ent", "pos": [26, 27]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "characterize", "by", "Northern", "blot", "HGF", "and", "C1704823#ent", "<e1>", "mRNA", "expression", "in", "rat", "C0771711#ent", "<e2>", "during", "development", "."], "h": {"id": "C1704823", "name": "C1704823#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [19, 20]}}
{"token": ["We", "now", "demonstrate", "that", "the", "protein", "affected", "binds", "C3536949#ent", "<e1>", "and", "has", "a", "basic", "heterodimeric", "structure", "with", "the", "C0599220#ent", "<e2>", "connected", "by", "disulfide", "bridging"], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [18, 19]}}
{"token": ["Production", "of", "C2985149#ent", "<e1>", "was", "increased", "by", "oestradiol-17", "beta", "tamoxifen", "and", "C2347999#ent", "<e2>"], "h": {"id": "C2985149", "name": "C2985149#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2347999", "name": "C2347999#ent", "pos": [11, 12]}}
{"token": ["Obstetric", "intervention", "and", "C0015930#ent", "<e1>", "more", "frequent", "in", "recent", "C0007789#ent", "<e2>", "cases", "than", "in", "the", "controls", "."], "h": {"id": "C0015930", "name": "C0015930#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [9, 10]}}
{"token": ["C1867800#ent", "<e1>", ",", "an", "oncogenic", "derivative", "of", "C1418285#ent", "<e2>", ",", "both", "retains", "its", "ability", "to", "heterodimerize", "with", "Hox", "proteins", "arrest", "myeloid", "differentiation"], "h": {"id": "C1867800", "name": "C1867800#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1418285", "name": "C1418285#ent", "pos": [7, 8]}}
{"token": ["Hydergine", ",", "an", "ergot", "mixture", "with", "partial", "dopaminergic", "and", "C0162757#ent", "<e1>", "activities", ",", "suppressed", "SP", "when", "C0342895#ent", "<e2>", "to", "10-", "to", "12-mo-old", ",", "middle-aged", "mice", "."], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [16, 17]}}
{"token": ["We", "have", "studied", "the", "cytotoxic", "effects", "C0014921#ent", "<e1>", "on", "the", "C1333200#ent", "<e2>", "organization", "of", "squirrelfish", "pigment", "cells", "(", "erythrophores", ")", "and", "human", "prostatic", "tumor", "cells", "DU", "145", ")", "in", "culture", "."], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333200", "name": "C1333200#ent", "pos": [10, 11]}}
{"token": ["Mammals", "have", "two", "paralogs", ",", "C3540489#ent", "<e1>", "and", "Cks2", ",", "and", "individually", "deleting", "the", "C0017337#ent", "<e2>", "encoding", "either", "in", "the", "mouse", "has", "previously", "been", "shown", "not", "to", "impact", "viability", "."], "h": {"id": "C3540489", "name": "C3540489#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["It", "is", "shown", "that", "CYP1A2", ",", "CYP2D6", ",", "CYP3A4", ",", "and", "C3714750#ent", "<e1>", "are", "the", "predominant", "C3541394#ent", "<e2>", "in", "the", "hydroxylation", "of", "KR-62980", "and", "KR-63198", "."], "h": {"id": "C3714750", "name": "C3714750#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["Polymorphism", "of", "the", "C3714750#ent", "<e1>", "known", "to", "influence", "the", "functionality", "of", "the", "CYP3A5", "C3541394#ent", "<e2>", "."], "h": {"id": "C3714750", "name": "C3714750#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["The", "hemolytic", "activity", "distinct", "from", "induced", "phospholipase", "A-like", "C1418638#ent", "<e1>", "that", "were", "detected", "in", "immune", "hemolymph", "which", "were", "inhibited", "by", "C0013618#ent", "<e2>", "."], "h": {"id": "C1418638", "name": "C1418638#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [20, 21]}}
{"token": ["To", "obtain", "functional", "information", "on", "activated", "CD4+", "CD8+", "T", "cells", "we", "studied", "the", "levels", "of", "soluble", "CD4", "(", "sCD4", ")", "and", "soluble", "C1706438#ent", "<e1>", "(", "sCD8", ")", "in", "serum", "from", "patients", "with", "C0263664#ent", "<e2>"], "h": {"id": "C1706438", "name": "C1706438#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0263664", "name": "C0263664#ent", "pos": [32, 33]}}
{"token": ["Our", "data", "demonstrate", "that", "in", "elderly", "females", "C1510471#ent", "<e1>", "secondary", "hyperparathyroidism", "associated", "with", "increased", "serum", "C1412791#ent", "<e2>", "levels", "indicating", "an", "increased", "bone", "formation", "these", "conditions", "might", "contribute", "to", "the", "bone", "disease", "geriatric", "patients", "."], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [15, 16]}}
{"token": ["C1142644#ent", "<e1>", "CYP3A4", ")", "converts", "an", "anticancer", "prodrug", "C0123931#ent", "<e2>", ",", "to", "inactive", "metabolites", "such", "as", "APC", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0123931", "name": "C0123931#ent", "pos": [8, 9]}}
{"token": ["Taken", "together", ",", "these", "data", "suggest", "that", "C1824378#ent", "<e1>", "has", "a", "unique", "role", "in", "the", "progression", "of", "experimental", "C2982413#ent", "<e2>", "."], "h": {"id": "C1824378", "name": "C1824378#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2982413", "name": "C2982413#ent", "pos": [18, 19]}}
{"token": ["C1142644#ent", "<e1>", "and", "CYP3A7", "mRNA", "expression", "levels", "were", "markedly", "up-regulated", "by", "C0011777#ent", "<e2>", "(", "DEX", ")", ",", "but", "not", "by", "rifampicin", "(", "RIF", ")", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [11, 12]}}
{"token": ["Because", "human", "platelets", "have", "a", "PAR", "expression", "profile", "similar", "to", "the", "non-human", "primate", "C1366449#ent", "<e1>", "antagonism", "has", "the", "potential", "to", "be", "C0016018#ent", "<e2>", "in", "humans", "."], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0016018", "name": "C0016018#ent", "pos": [21, 22]}}
{"token": ["The", "stimulation", "of", "C0524889#ent", "<e1>", "cross-linked", "anti-CD3", "mAb", "in", "a", "rapid", "increase", "of", "the", "phosphatidylinositol-specific", "phospholipase", "C", "C3810542#ent", "<e2>", ")", "activity", "in", "whole", "cell", "lysates"], "h": {"id": "C0524889", "name": "C0524889#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3810542", "name": "C3810542#ent", "pos": [17, 18]}}
{"token": ["Recently", ",", "an", "increased", "frequency", "of", "the", "A1/A1", "genotype", "of", "an", "C1516869#ent", "<e1>", "IL-1Ra", ")", "gene", "polymorphism", "observed", "in", "patients", "with", "C0011854#ent", "<e2>", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [21, 22]}}
{"token": ["Previous", "studies", "in", "this", "laboratory", "have", "shown", "that", "C0005080#ent", "<e1>", "(", "BaP", ")", "modulates", "C0033634#ent", "<e2>", "phosphorylation", "of", "aortic", "smooth", "muscle", "cell", "SMC", ")", "proteins", "."], "h": {"id": "C0005080", "name": "C0005080#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [14, 15]}}
{"token": ["Six", "homodimer", "families", "are", "analyzed", ":", "alkaline", "phosphatase", "C0031691#ent", "<e1>", ",", "glutathione", "S-transferase", "copper-zinc", "superoxide", "dismutase", "Streptomyces", "subtilisin", "inhibitor", ",", "and", "C3887669#ent", "<e2>"], "h": {"id": "C0031691", "name": "C0031691#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [21, 22]}}
{"token": ["The", "seven", "enzymes", "isolated", "were", ":", "phosphorylase", ",", "C0031691#ent", "<e1>", ",", "creatine-P", "kinase", "aldolase", ",", "glyceraldehyde-3-P", "dehydrogenase", "phosphoglycerate", "mutase", "and", "C3887669#ent", "<e2>"], "h": {"id": "C0031691", "name": "C0031691#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [20, 21]}}
{"token": ["Sequence", "and", "structural", "analyses", "reveal", "that", "C1824956#ent", "<e1>", "belongs", "to", "a", "family", "of", "C0057440#ent", "<e2>", "consisting", "of", "eight", "tandem", "repeats", "an", "alpha-helical", "pair", "HEAT", "motif", "organized", "in", "a", "symmetrical", "dyad", "."], "h": {"id": "C1824956", "name": "C1824956#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0057440", "name": "C0057440#ent", "pos": [13, 14]}}
{"token": ["C1571621#ent", "<e1>", "expressed", "with", "high", "level", "after", "C0039512#ent", "<e2>", "induction", "using", "the", "strain", "E.", "coli", ")", "."], "h": {"id": "C1571621", "name": "C1571621#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [7, 8]}}
{"token": ["These", "scaffolds", "include", "KSR", "(", "kinase", "suppressor", "Ras", ")", ",", "beta-arrestin", ",", "C0752313#ent", "<e1>", "partner-1", ",", "Sef", "and", "C1416471#ent", "<e2>", "."], "h": {"id": "C0752313", "name": "C0752313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416471", "name": "C1416471#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "Rheb", "overexpression", "induces", "C1419748#ent", "<e1>", "phosphorylation", "and", "inhibits", "C0285558#ent", "<e2>", "phosphorylation", ",", "as", "do", "loss-of-function", "mutations", "in", "TSC1/2", ",", "but", "contrary", "to", "earlier", "reports", "Rheb", "has", "no", "effect", "MAPK", "phosphorylation", "."], "h": {"id": "C1419748", "name": "C1419748#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "we", "proposed", "that", "the", "public", "health", "programme", "focus", "on", "preventive", "activities", "reduce", "C0221019#ent", "<e1>", "the", "rate", "of", "C1257763#ent", "<e2>", "to", "solve", "the", "problem", "of", "anemia", "in", "Thailand", "."], "h": {"id": "C0221019", "name": "C0221019#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1257763", "name": "C1257763#ent", "pos": [19, 20]}}
{"token": ["Each", "prophylactic", "procedure", "performed", "without", "any", "significant", "adverse", "effect", "for", "seizure", "induced", "by", "C0002335#ent", "<e1>", "in", "one", "patient", "with", "C0238111#ent", "<e2>"], "h": {"id": "C0002335", "name": "C0002335#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [19, 20]}}
{"token": ["This", "retrospective", "study", "4", "cases", "of", "canine", "C0004576#ent", "<e1>", "with", "histologically", "confirmed", "C0001339#ent", "<e2>"], "h": {"id": "C0004576", "name": "C0004576#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [12, 13]}}
{"token": ["Extracts", "from", "steam-autoclaved", ",", "dry-stored", ",", "or", "gamma-sterilised", ",", "wet-stored", "C0056591#ent", "<e1>", "and", "hemophan", "modules", "resulted", "in", "C1522428#ent", "<e2>", "activity", "that", "did", "not", "differ", "from", "negative", "controls"], "h": {"id": "C0056591", "name": "C0056591#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [17, 18]}}
{"token": ["Substrates", "for", "C0608437#ent", "<e1>", "include", "fluoxetine", ",", "C0031507#ent", "<e2>", ",", "warfarin", ",", "losartam", "and", "numerous", "nonsteroidal", "anti-inflammatory", "drugs"], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [2, 3]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [7, 8]}}
{"token": ["In", "the", "incubation", "study", "using", "cDNA-expressed", "P450s", ",", "both", "C0608437#ent", "<e1>", "and", "CYP2C19", "catalyzed", "C0031507#ent", "<e2>", "p-hydroxylation", ",", "whereas", "TCAs", "inhibited", "only", "the", "CYP2C19", "pathway", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [9, 10]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [14, 15]}}
{"token": ["Carbohydrate-deficient", "glycoprotein", "syndrome", "characterized", "by", "mental", "retardation", "C0007758#ent", "<e1>", ",", "hepatopathy", "during", "infancy", ",", "cerebellar", "hypoplasia", "peripheral", "neuropathy", "C0015310#ent", "<e2>", "growth", "retardation", "stroke-like", "episodes"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015310", "name": "C0015310#ent", "pos": [18, 19]}}
{"token": ["IL-27", "is", "a", "member", "of", "the", "IL-6/IL-12", "family", "and", "activates", "both", "STAT1", "and", "C1367307#ent", "<e1>", "through", "its", "receptor", ",", "which", "consists", "of", "C1424880#ent", "<e2>", "and", "gp130", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1424880", "name": "C1424880#ent", "pos": [22, 23]}}
{"token": ["Exisulind", "(", "C0075616#ent", "<e1>", "and", "two", "potent", "derivatives", ",", "CP248", "and", "C1101538#ent", "<e2>", ",", "have", "been", "shown", "previously", "to", "cause", "growth", "inhibition", "apoptosis", "in", "several", "types", "of", "human", "carcinoma", "cell", "lines"], "h": {"id": "C0075616", "name": "C0075616#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1101538", "name": "C1101538#ent", "pos": [11, 12]}}
{"token": ["C0075616#ent", "<e1>", "(", "sulindac", "sulfone", "and", "two", "potent", "derivatives", ",", "CP248", "and", "C1101538#ent", "<e2>", ",", "have", "been", "shown", "previously", "to", "cause", "growth", "inhibition", "apoptosis", "in", "several", "types", "of", "human", "carcinoma", "cell", "lines"], "h": {"id": "C0075616", "name": "C0075616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1101538", "name": "C1101538#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "of", "this", "study", "was", "evaluate", "the", "efficacy", "and", "ocular", "discomfort", "substituting", "brinzolamide", "for", "C1512042#ent", "<e1>", "in", "patients", "with", "C0017601#ent", "<e2>", "treated", "by", "latanoprost", ",", "timolol", ",", "and", "C1512042#ent", "<e1>", "."], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1512042", "name": "C1512042#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "C1334119#ent", "<e1>", "reduced", "LPS-", "and", "PMA-induced", "C1333522#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333522", "name": "C1333522#ent", "pos": [8, 9]}}
{"token": ["C1334119#ent", "<e1>", "had", "a", "concentration-dependent", "inhibitory", "effect", "on", "functional", "C1333522#ent", "<e2>", "procoagulant", "activity", "(", "PCA", ")", "and", "reduced", "the", "binding", "of", "an", "anti-TF", "antibody", "as", "assessed", "by", "flow", "cytometry", "analysis"], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333522", "name": "C1333522#ent", "pos": [9, 10]}}
{"token": ["Impaired", "cutaneous", "wound", "healing", "a", "common", "complication", "in", "diabetes", ",", "ischemia", "and", "C0042485#ent", "<e1>", "lower", "extremities", "and", "in", "long-term", "treatment", "with", "C3540725#ent", "<e2>", "or", "other", "immunosuppressive", "agents"], "h": {"id": "C0042485", "name": "C0042485#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [21, 22]}}
{"token": ["C1706230#ent", "<e1>", "equivalently", "Ia+", "after", "the", "culture", "period", "with", "or", "without", "C0175697#ent", "<e2>", "stimulation", "."], "h": {"id": "C1706230", "name": "C1706230#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [11, 12]}}
{"token": ["C0017536#ent", "<e1>", ":", "of", "74", "children", "with", "symptomatic", "giardiasis", "given", "C0040263#ent", "<e2>", "in", "a", "single", "dose", "approximately", "50", "mg/kg", "body", "weight", "65", "(", "88", "%", ")", "were", "parasitologically", "and", "symptomatically", "cured", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0040263", "name": "C0040263#ent", "pos": [10, 11]}}
{"token": ["To", "measure", "in", "vitro", "cytokine", "release", "from", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "and", "serum", "cytokines", "patients", "with", "primary", "Sj\u00f6gren's", "syndrome", "SS", ")", "with", "and", "without", "C0231528#ent", "<e1>", ",", "compared", "to", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "and", "healthy", "controls"], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [33, 34]}}
{"token": ["To", "measure", "in", "vitro", "cytokine", "release", "from", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "and", "serum", "cytokines", "patients", "with", "primary", "Sj\u00f6gren's", "syndrome", "SS", ")", "with", "and", "without", "C0231528#ent", "<e1>", ",", "compared", "to", "patients", "with", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "and", "healthy", "controls"], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [35, 36]}}
{"token": ["Both", "PT-VWD", "and", "type", "2B", "VWD", "represent", "an", "enhanced", "binding", "between", "the", "plasma", "von", "Willebrand", "factor", "C1336938#ent", "<e1>", ")", "to", "its", "platelet", "ligand", "glycoprotein", "Ib", "alpha", "C1415186#ent", "<e2>", ")", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415186", "name": "C1415186#ent", "pos": [26, 27]}}
{"token": ["Both", "PT-VWD", "and", "2B-VWD", "represent", "gain-of-function", "mutations", "that", "lead", "to", "enhanced", "binding", "between", "plasma", "von", "Willebrand", "factor", "C1336938#ent", "<e1>", ")", "and", "its", "platelet", "ligand", "glycoprotein", "Ib", "alpha", "C1415186#ent", "<e2>", ")", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415186", "name": "C1415186#ent", "pos": [27, 28]}}
{"token": ["C0023556#ent", "<e1>", "was", ",", "however", ",", "only", "marginally", "more", "effective", "than", "C0023660#ent", "<e2>", "in", "reverting", "to", "sinus", "rhythm", ",", "barium", "chloride-induced", "ventricular", "dysrhythmia", "the", "rat", "."], "h": {"id": "C0023556", "name": "C0023556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023660", "name": "C0023660#ent", "pos": [11, 12]}}
{"token": ["It", "is", "possible", "to", "measure", "AChE", "activity", "in", "human", "plasma", "in", "spite", "of", "high", "C0728810#ent", "<e1>", "activity", "if", "C0053526#ent", "<e2>", "is", "used", "as", "the", "substrate", "and", "C0728810#ent", "<e1>", "is", "inhibited", "by", "iso-OMPA", "."], "h": {"id": "C0053526", "name": "C0053526#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0728810", "name": "C0728810#ent", "pos": [14, 15]}}
{"token": ["As", "part", "of", "the", "search", "for", "new", "C0003374#ent", "<e1>", "a", "screening", "program", "developed", "using", "sensitive", "and", "C0008241#ent", "<e2>", "CGT", ",", "cycloguanil", ")", "resistant", "strains", "of", "the", "folate-requiring", "bacteria", ",", "Streptococcus", "faecium", "durans", "Lactobacillus", "casei", "and", "Pediococcus", "cerevisiae"], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0008241", "name": "C0008241#ent", "pos": [16, 17]}}
{"token": ["Several", "enzymological", "studies", "and", "crystallographic", "structures", "available", "for", "the", "NS3", "protease", "and", "C1310463#ent", "<e1>", ",", "but", "less", "is", "known", "about", "the", "NTPase", "and", "C1333949#ent", "<e2>", "activities", "of", "the", "full-length", "protein", "."], "h": {"id": "C1310463", "name": "C1310463#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [23, 24]}}
{"token": ["Thus", ",", "it", "was", "possible", "to", "interpret", "muscle", "twitching", "C0026821#ent", "<e1>", "by", "EMG", "and", "separate", "neurogenic", "from", "C0026848#ent", "<e2>"], "h": {"id": "C0026821", "name": "C0026821#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [17, 18]}}
{"token": ["We", "present", "a", "case", "of", "C2973725#ent", "<e1>", "a", "woman", "with", "a", "history", "of", "fenfluramine", "and", "C0031447#ent", "<e2>", "use", "who", "presented", "with", "diffuse", "micronodules", "on", "computed", "tomography", "scan"], "h": {"id": "C2973725", "name": "C2973725#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031447", "name": "C0031447#ent", "pos": [15, 16]}}
{"token": ["However", ",", "it", "was", "soon", "recognized", "that", "a", "subset", "of", "ALCLs", "contained", "chromosomal", "translocations", "anaplastic", "lymphoma", "kinase", "C1663627#ent", "<e1>", ")", ",", "a", "novel", "C1335675#ent", "<e2>"], "h": {"id": "C1663627", "name": "C1663627#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335675", "name": "C1335675#ent", "pos": [23, 24]}}
{"token": ["We", "studied", "the", "effect", "of", "a", "quick-release", "C0006230#ent", "<e1>", "formulation", "on", "glucose", "homeostasis", "insulin", "sensitivity", "obese", "C0011860#ent", "<e2>", "subjects", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [16, 17]}}
{"token": ["A", "brief", "exposure", "of", "C1516687#ent", "<e1>", "vanadate", ",", "a", "C0597217#ent", "<e2>", "significantly", "increased", "the", "level", "of", "i-NOS", "tyrosine", "phosphorylation", "suggesting", "that", "tyrosine", "phosphatases", "dynamically", "involved", "in", "the", "regulation", "of", "this", "process", "."], "h": {"id": "C1516687", "name": "C1516687#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597217", "name": "C0597217#ent", "pos": [9, 10]}}
{"token": ["This", "paper", "highlights", "the", "prevalence", "of", "other", "C0029896#ent", "<e1>", "such", "as", "herpes", "simplex", "C0276828#ent", "<e2>", "and", "candidiasis", "which", "are", "also", "sexually", "transmitted"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0276828", "name": "C0276828#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "perinatal", "C0012010#ent", "<e1>", "exposure", "led", "to", "a", "transient", "decrease", "in", "C0012278#ent", "<e2>", "binding", "limited", "to", "the", "frontal", "cortex"], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012278", "name": "C0012278#ent", "pos": [13, 14]}}
{"token": ["Amyloid", "beta", "protein", "beta", "A4", ",", "the", "major", "component", "of", "the", "core", "of", "amyloid", "plaques", "in", "C0002395#ent", "<e1>", "is", "derived", "from", "the", "transmembrane", "amyloid", "precursor", "proteins", "(", "C1332804#ent", "<e2>", ")", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [16, 17]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [27, 28]}}
{"token": ["To", "clarify", "the", "relation", "between", "C0006507#ent", "<e1>", ",", "OCR", "and", "C0720099#ent", "<e2>", "of", "palsy", ",", "the", "BHT/OCR", "ratio", "was", "calculated", "in", "each", "patient", "."], "h": {"id": "C0006507", "name": "C0006507#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [10, 11]}}
{"token": ["Acute", "CP", "treatment", "caused", "an", "impairment", "in", "C3813124#ent", "<e1>", "phagocytosis", "and", "binding", "of", "sheep", "red", "blood", "cells", "with", "C3536873#ent", "<e2>", "IgG", ")", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536873", "name": "C3536873#ent", "pos": [18, 19]}}
{"token": ["Human", "alpha", "1-acid", "glycoprotein", "AGP", "or", "C1418186#ent", "<e1>", ")", "is", "a", "major", "C0072522#ent", "<e2>", "plasma", "."], "h": {"id": "C1418186", "name": "C1418186#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}}
{"token": ["Umbilical", "cords", "collected", "at", "delivery", "from", "20", "newborns", "without", "C1275592#ent", "<e1>", ",", "6", "newborns", "with", "acute", "funisitis", "and", "4", "newborns", "with", "C3898153#ent", "<e2>"], "h": {"id": "C1275592", "name": "C1275592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3898153", "name": "C3898153#ent", "pos": [21, 22]}}
{"token": ["This", "activity", "was", "inhibited", "with", "N-ethylmaleimide", ",", "C0669516#ent", "<e1>", "cytochrome", "c", "catalase", ",", "desferrioxamine", ",", "mannitol", ",", "and", "C0220795#ent", "<e2>", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0220795", "name": "C0220795#ent", "pos": [18, 19]}}
{"token": ["C0241910#ent", "<e1>", "AIH", ")", "and", "C0524611#ent", "<e2>", "CCH", ")", "are", "important", "causes", "of", "liver", "failure", "children", ",", "frequently", "necessitating", "orthotopic", "liver", "transplantation", "OLT", ")", "."], "h": {"id": "C0241910", "name": "C0241910#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0524611", "name": "C0524611#ent", "pos": [5, 6]}}
{"token": ["The", "pathologic", "abnormalities", "in", "patients", "with", "SLE", "have", "been", "classified", "as", "follows", ":", "minimal", "C4053959#ent", "<e1>", "mild", "(", "focal", ")", "proliferative", "C4053959#ent", "<e1>", "severe", "(", "diffuse", ")", "proliferative", "C4053959#ent", "<e1>", "and", "C0024143#ent", "<e1>"], "h": {"id": "C4053959", "name": "C4053959#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [31, 32]}}
{"token": ["The", "subjects", "were", "54", "patients", "with", "diffuse", "proliferative", "lupus", "nephritis", "6", "patients", "with", "C4053959#ent", "<e1>", "from", "143", "patients", "with", "C0024143#ent", "<e2>"], "h": {"id": "C4053959", "name": "C4053959#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0024143", "name": "C0024143#ent", "pos": [19, 20]}}
{"token": ["The", "clinical", "results", "that", "local", "injection", "of", "a", "minute", "dose", "botulinum", "A", "toxin", "treating", "C0005747#ent", "<e1>", ",", "hemifacial", "spasm", "strabismus", "and", "C0014390#ent", "<e2>", "is", "a", "safe", ",", "effective", "and", "simple", "method", "of", "nonsurgical", "therapy", "."], "h": {"id": "C0005747", "name": "C0005747#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014390", "name": "C0014390#ent", "pos": [21, 22]}}
{"token": ["The", "injections", "of", "C1415169#ent", "<e1>", "LH-RH", ")", "and", "of", "melanocyte", "stimulating", "hormone", "release-inhibiting", "factor", "C1412384#ent", "<e2>", ")", "were", "also", "ineffective", "."], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412384", "name": "C1412384#ent", "pos": [14, 15]}}
{"token": ["Patients", "who", "received", "C3540800#ent", "<e1>", "experienced", "significantly", "less", "C0152149#ent", "<e2>", "leukocyte", "and", "neutrophil", "count", "depression", "spent", "fewer", "days", "with", "leukopenia", "and", "neutropenia", "than", "control", "patients", "regardless", "of", "age", "or", "extent", "of", "disease", "."], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0152149", "name": "C0152149#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "we", "demonstrated", "that", "immunodominant", "species-specific", "C0872913#ent", "<e1>", "and", "B-cell", "epitopes", "be", "found", "in", "a", "mycobacterial", "C0063423#ent", "<e2>", "its", "highly", "conserved", "amino", "acid", "sequence"], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0063423", "name": "C0063423#ent", "pos": [18, 19]}}
{"token": ["To", "identify", "C0872913#ent", "<e1>", "and/or", "cross-reactive", "B-cell", "of", "P.", "gingivalis", "human", "C0063423#ent", "<e2>", "in", "atherosclerosis", "patients", ",", "we", "synthesized", "104", "overlapping", "synthetic", "peptides", "whole", "molecules", "of", "P.", "gingivalis", "HSP60", "and", "human", "HSP60", ",", "respectively", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0063423", "name": "C0063423#ent", "pos": [11, 12]}}
{"token": ["Newer", "agents", "under", "active", "investigation", "C1701991#ent", "<e1>", "CERA", ")", "or", "proline", "hydroxylase", "inhibitors", "increase", "hypoxia-inducible", "factor-1", "C1822686#ent", "<e2>", ")", ",", "thereby", "stimulating", "Epo", "production", "and", "iron", "availability", "and", "supply", "."], "h": {"id": "C1701991", "name": "C1701991#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1822686", "name": "C1822686#ent", "pos": [16, 17]}}
{"token": ["A", "synthetic", "analogue", "calcitriol", ",", "C0043872#ent", "<e1>", "(", "OCT", ")", ",", "strongly", "suppresses", "parathyroid", "hormone", "C1705340#ent", "<e2>", ")", "secretion", "."], "h": {"id": "C0043872", "name": "C0043872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [15, 16]}}
{"token": ["This", "study", "was", "purposed", "to", "investigate", "whether", "C0099413#ent", "<e1>", "PHI", ")", "can", "reduce", "C0525037#ent", "<e2>", "methylation", "level", "or", "not", "."], "h": {"id": "C0099413", "name": "C0099413#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [13, 14]}}
{"token": ["HR", "and", "C2699119#ent", "<e1>", "were", "significantly", "(", "p", "<", "0.05", ")", "lower", "in", "C1333925#ent", "<e2>", "and", "DP15", "compared", "with", "CP", "for", "the", "BP", "exercise", "."], "h": {"id": "C2699119", "name": "C2699119#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333925", "name": "C1333925#ent", "pos": [13, 14]}}
{"token": ["XAD-16", "has", "higher", "adsorption", "capacities", "for", "the", "total", "C0949988#ent", "<e1>", "well", "as", "for", "both", "the", "enzymes", ",", "C0002272#ent", "<e2>", "and", "invertase", ",", "than", "NPA-1", "in", "its", "respective", "native", "and", "grafted", "form", "."], "h": {"id": "C0949988", "name": "C0949988#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [17, 18]}}
{"token": ["C0053413#ent", "<e1>", "also", "inhibited", "Env", "binding", "to", "surface", "glycopeptides", "obtained", "after", "C0960371#ent", "<e2>", "treatment", "of", "macrophages", "."], "h": {"id": "C0053413", "name": "C0053413#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C0087093#ent", "<e1>", "is", "effective", "in", "reducing", "C0020538#ent", "<e2>", "short-term", "therapy", "and", "in", "maintaining", "this", "effect", "over", "the", "long", "term", "responsive", "subjects", "."], "h": {"id": "C0087093", "name": "C0087093#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [8, 9]}}
{"token": ["The", "molecular", "analysis", "the", "GIST", ",", "the", "first", "reported", "in", "a", "gastric", "tumor", "the", "triad", ",", "showed", "a", "C2987364#ent", "<e1>", "KIT", "and", "C1705319#ent", "<e2>", "genes", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705319", "name": "C1705319#ent", "pos": [22, 23]}}
{"token": ["We", "studied", "postoperative", "swallowing", "in", "4", "patients", "undergoing", "C0162569#ent", "<e1>", "and", "1", "undergoing", "C1425440#ent", "<e2>", "."], "h": {"id": "C0162569", "name": "C0162569#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425440", "name": "C1425440#ent", "pos": [13, 14]}}
{"token": ["By", "chromatin", "immunoprecipitation", "analysis", "C1825795#ent", "<e1>", "treatment", "released", "C2348049#ent", "<e2>", ",", "HDAC1", ",", "and", "the", "H3", "lysine", "9", "H3-K9", ")", "methyltransferase", "SUV39H", "1", "from", "the", "ER", "promoter", "."], "h": {"id": "C1825795", "name": "C1825795#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2348049", "name": "C2348049#ent", "pos": [8, 9]}}
{"token": ["The", "levels", "of", "the", "protein", "encoded", "by", "this", "mRNA", "are", "also", "elevated", "in", "C0011860#ent", "<e1>", "tissues", ";", "thus", ",", "we", "named", "it", "C1418449#ent", "<e2>", "for", "phosphoprotein", "enriched", "in", "diabetes", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [13, 14]}, "relation": "disease_has_associated_gene", "t": {"id": "C1418449", "name": "C1418449#ent", "pos": [22, 23]}}
{"token": ["Among", "C0028064#ent", "<e1>", "metachromatic", "leukodystrophy", "the", "commonest", ",", "followed", "by", "Krabbe's", "disease", "C0039373#ent", "<e2>", "Gaucher", "disease"], "h": {"id": "C0028064", "name": "C0028064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0039373", "name": "C0039373#ent", "pos": [12, 13]}}
{"token": ["Rat", "hepatocytes", "were", "treated", "with", "clofibrate", "or", "PFDA", "individually", ",", "or", "along", "with", "PXR", "ligand", "pregnenolone", "16alpha-carbonitrile", "C1418643#ent", "<e1>", ")", ",", "and", "the", "levels", "of", "PXR", "and", "C0670679#ent", "<e2>", "were", "determined", "by", "Western", "blots"], "h": {"id": "C1418643", "name": "C1418643#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0670679", "name": "C0670679#ent", "pos": [27, 28]}}
{"token": ["FK506", "also", "blocked", "the", "decrease", "of", "CXCR6", "expression", "caused", "by", "C0022020#ent", "<e1>", ",", "whereas", "staurosporine", "or", "C1417819#ent", "<e2>", "had", "no", "effect", "this", "decrease", "."], "h": {"id": "C0022020", "name": "C0022020#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417819", "name": "C1417819#ent", "pos": [16, 17]}}
{"token": ["Treatment", "modalities", "C0520679#ent", "<e1>", "with", "C1423108#ent", "<e2>", "include", "continuous", "positive", "airway", "pressure", "bilevel", "or", "variable", "C1423108#ent", "<e2>", ",", "and", "autotitrating", "PAP", "."], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [5, 6]}}
{"token": ["This", "study", "was", "designed", "to", "assess", "whether", "glomerular", "mRNA", "expression", "of", "growth-related", "proto-oncogenes", "in", "diabetic", "rat", "C0268731#ent", "<e1>", "is", "affected", "by", "a", "specific", "C2936801#ent", "<e2>", "FR139317", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2936801", "name": "C2936801#ent", "pos": [23, 24]}}
{"token": ["During", "the", "calcium", "switch", ",", "there", "were", "reversible", "changes", "in", "localization", "and", "detergent", "solubility", "of", "the", "slit", "diaphragm", "protein", "C1420744#ent", "<e1>", "and", "alpha-actinin-4", ",", "whereas", "C1417784#ent", "<e2>", "and", "podocin", "solubility", "were", "unchanged", "."], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1417784", "name": "C1417784#ent", "pos": [25, 26]}}
{"token": ["In", "addition", ",", "Dvl", "and", "C1705717#ent", "<e1>", "can", "activate", "the", "C0752312#ent", "<e2>", "distinct", "mechanisms", ",", "through", "interaction", "with", "MEKK1/4", "and", "Rac", "GTPase", "respectively", "."], "h": {"id": "C1705717", "name": "C1705717#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [10, 11]}}
{"token": ["We", "found", "the", "presence", "of", "hepatitis", "B", "virus", "17", "cases", "of", "C0019196#ent", "<e1>", "the", "DNA", "detection", "technique", "serum", "of", "patients", "with", "a", "type", "of", "C0341439#ent", "<e2>"], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0341439", "name": "C0341439#ent", "pos": [24, 25]}}
{"token": ["In", "clinical", "trials", "C0657912#ent", "<e1>", "has", "been", "shown", "to", "be", "effective", "in", "C0032768#ent", "<e2>", "painful", "diabetic", "neuropathy", "doses", "ranging", "from", "150", "-", "600", "mg/day", "."], "h": {"id": "C0657912", "name": "C0657912#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0032768", "name": "C0032768#ent", "pos": [12, 13]}}
{"token": ["Under", "this", "experimental", "condition", "effects", "of", "divalent", "metal", "cations", "on", "the", "hexagonal", "assembly", "the", "electrodialyzed", "C2697656#ent", "<e1>", "were", "compared", "with", "that", "of", "C1333909#ent", "<e2>", "+", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [22, 23]}}
{"token": ["Pyrene-labeled", "thioesterase", "II", "does", "not", "exhibit", "increased", "fluorescence", "anisotropy", "mixed", "with", "C3658233#ent", "<e1>", "suggesting", "that", "the", "C3540017#ent", "<e2>", "do", "not", "readily", "form", "a", "complex", "."], "h": {"id": "C3658233", "name": "C3658233#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540017", "name": "C3540017#ent", "pos": [16, 17]}}
{"token": ["At", "a", "subcellular", "level", "C0082608#ent", "<e1>", "treatment", "was", "associated", "with", "reduced", "functional", "activity", "C0082529#ent", "<e2>", "of", "Rho-dependent", "p38", "activation", "."], "h": {"id": "C0082608", "name": "C0082608#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [13, 14]}}
{"token": ["When", "we", "examined", "the", "survival", "signals", "the", "time", "of", "apoptotic", "induction", "we", "also", "found", "that", "C0082608#ent", "<e1>", "had", "caused", "a", "remarkable", "decrease", "in", "the", "phosphorylation", "of", "C0082529#ent", "<e2>", "ERK", ")", "1/2", "."], "h": {"id": "C0082608", "name": "C0082608#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [26, 27]}}
{"token": ["The", "introduction", "of", "the", "C0387583#ent", "<e1>", "inhibitors", "promises", "to", "significantly", "affect", "nonsteroidal", "anti-inflammatory", "drug", "NSAID", ")", "C0038354#ent", "<e2>", "."], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038354", "name": "C0038354#ent", "pos": [16, 17]}}
{"token": ["Extracellular", "deposition", "both", "major", "basic", "protein", "and", "C0699918#ent", "<e1>", "was", "identified", "in", "orbital", "tissues", "all", "the", "patients", "with", "C3495801#ent", "<e2>"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3495801", "name": "C3495801#ent", "pos": [18, 19]}}
{"token": ["The", "C1823096#ent", "<e1>", "is", "an", "C1290886#ent", "<e2>", "the", "mucous", "of", "nose", "sinuses", "."], "h": {"id": "C1823096", "name": "C1823096#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1290886", "name": "C1290886#ent", "pos": [5, 6]}}
{"token": ["A", "20-month-old", "girl", "with", "developmental", "delay", "dysmorphic", "features", "horizontal", "supranuclear", "gaze", "palsy", "C3887667#ent", "<e1>", ",", "and", "episodes", "of", "C0023066#ent", "<e2>", "was", "diagnosed", "with", "variant", "neuronopathic", "Gaucher", "disease"], "h": {"id": "C3887667", "name": "C3887667#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023066", "name": "C0023066#ent", "pos": [18, 19]}}
{"token": ["Treatment", "with", "C0033634#ent", "<e1>", "PKC", ")", "inhibitors", "prevented", "the", "increase", "in", "C3887964#ent", "<e2>", "activity", "induced", "by", "RacV12", "and", "aluminum", "fluoride-stimulated", "Galpha12/13", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3887964", "name": "C3887964#ent", "pos": [11, 12]}}
{"token": ["Formin-binding", "protein", "17", "FBP17", ")", "and", "Toca-1", "contain", "EFC/F-BAR", "domains", "and", "bind", "to", "neural", "Wiskott-Aldrich", "syndrome", "protein", "N-WASP", ")", ",", "which", "links", "phosphatidylinositol", "(4,5)-bisphosphate", "PIP(2", ")", ")", "and", "the", "C1425441#ent", "<e1>", "Cdc42", "to", "the", "C1412171#ent", "<e2>"], "h": {"id": "C1425441", "name": "C1425441#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C1412171", "name": "C1412171#ent", "pos": [34, 35]}}
{"token": ["Consistent", "with", "reported", "fish", "intake", ",", "higher", "levels", "of", "plasma", "C1420709#ent", "<e1>", "and", "PL", "C2348308#ent", "<e2>", "are", "associated", "with", "progression", "of", "coronary", "atherosclerosis", "postmenopausal", "women", "with", "CAD", "."], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2348308", "name": "C2348308#ent", "pos": [14, 15]}}
{"token": ["From", "these", "and", "other", "studies", ",", "we", "postulate", "that", "independent", "signaling", "pathways", "to", "5-HT-induced", "C1539322#ent", "<e1>", "proliferation", "are", "initiated", "through", "multiple", "5-HT", "receptors", "C1420214#ent", "<e2>", "the", "cell", "surface"], "h": {"id": "C1539322", "name": "C1539322#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420214", "name": "C1420214#ent", "pos": [23, 24]}}
{"token": ["Besides", ",", "it", "was", "detected", "that", "C0340293#ent", "<e1>", "patients", "with", "4a/4a", "polymorphism", "had", "bronchial", "asthma", "C0524909#ent", "<e2>", "frequently", "than", "patients", "with", "4b/4b", "genotype", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [15, 16]}}
{"token": ["In", "experimental", "models", "C0085292#ent", "<e1>", "prevent", "or", "arrest", "inflammatory", "damage", ",", "and", "initial", "clinical", "trials", "C1290886#ent", "<e2>", "shown", "HSP", "peptides", "to", "promote", "production", "of", "anti-inflammatory", "cytokines-indicating", "immunoregulatory", "potential"], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1290886", "name": "C1290886#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggested", "that", "both", "C0082529#ent", "<e1>", "PI3K/Akt", "pathways", "participated", "in", "C1705323#ent", "<e2>", "expression", "induced", "by", "S1P", "in", "VSMCs", "."], "h": {"id": "C0082529", "name": "C0082529#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [11, 12]}}
{"token": ["The", "alga", "grew", "well", "heterotrophically", "and", "produced", "intracellular", "C1421114#ent", "<e1>", "using", "Polypepton", ",", "yeast", "extract", "and", "C0017868#ent", "<e2>", "as", "nutrients", "."], "h": {"id": "C1421114", "name": "C1421114#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [16, 17]}}
{"token": ["As", "the", "research", "progresses", ",", "scientists", "hope", "to", "bolster", "elderly", "people", "'s", "response", "to", "C0009450#ent", "<e1>", "quiet", "the", "inflammation", "that", "can", "make", "aging", "a", "C0239377#ent", "<e2>", "experience", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [24, 25]}}
{"token": ["We", "show", "here", "that", "a", "putative", "tumor", "suppressor", "C1333930#ent", "<e1>", ",", "also", "called", "CC3", "or", "C1336577#ent", "<e2>", ",", "interacts", "with", "an", "ERalpha-interacting", "coactivator", "CIA", "."], "h": {"id": "C1333930", "name": "C1333930#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1336577", "name": "C1336577#ent", "pos": [15, 16]}}
{"token": ["Several", "substances", "have", "been", "evaluated", "as", "possible", "C1332838#ent", "<e1>", ",", "but", "no", "C1136254#ent", "<e2>", "with", "the", "exception", "of", "fluoride", ",", "has", "received", "as", "much", "experimental", "attention", "as", "the", "bisbiguanide", "chlorhexidine", "."], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [12, 13]}}
{"token": ["C0004763#ent", "<e1>", "an", "X-linked", "dominant", "disorder", "by", "MECP2", "mutations", ",", "and", "C0162635#ent", "<e2>", "an", "imprinted", "disorder", "caused", "by", "maternal", "15q11-q13", "or", "UBE3A", "deficiency", ",", "have", "phenotypic", "and", "genetic", "overlap", "autism", "."], "h": {"id": "C0004763", "name": "C0004763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162635", "name": "C0162635#ent", "pos": [11, 12]}}
{"token": ["Esters", "of", "C0034239#ent", "<e1>", "to", "circumvent", "the", "requirement", "for", "activation", "by", "C0026918#ent", "<e2>"], "h": {"id": "C0034239", "name": "C0034239#ent", "pos": [2, 3]}, "relation": "may_prevent", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [11, 12]}}
{"token": ["The", "amplitude", "of", "the", "effect", "of", "C0088321#ent", "<e1>", "and", "C1412179#ent", "<e2>", "similar", "in", "the", "CA1", "area", "but", "in", "the", "CA3", "area", "C0088321#ent", "<e1>", "produced", "a", "greater", "effect", "than", "C1412179#ent", "<e2>"], "h": {"id": "C0088321", "name": "C0088321#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412179", "name": "C1412179#ent", "pos": [9, 10]}}
{"token": ["It", "appears", "that", "the", "5-HT(2C)", "receptors", "more", "implicated", "in", "the", "function", "of", "mediating", "the", "anxiolytic", "effect", "C0056643#ent", "<e1>", "in", "the", "C1823140#ent", "<e2>", "."], "h": {"id": "C0056643", "name": "C0056643#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1823140", "name": "C1823140#ent", "pos": [20, 21]}}
{"token": ["Novel", "potent", "trisubstituted", "pyridazine", "inhibitors", "of", "p38", "MAP", "mitogen", "activated", "protein", "kinase", "are", "described", "that", "have", "activity", "in", "both", "cell-based", "assays", "of", "C1333196#ent", "<e1>", "release", "and", "animal", "models", "C0038013#ent", "<e2>"], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [28, 29]}}
{"token": ["To", "determine", "whether", "a", "continuous", "intravenous", "infusion", "of", "pentoxifylline", ",", "a", "C0006644#ent", "<e1>", "alters", "the", "serum", "C1333196#ent", "<e2>", "concentrations", "and/or", "hemodynamic", "measurements", "in", "patients", "with", "septic", "shock"], "h": {"id": "C0006644", "name": "C0006644#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [16, 17]}}
{"token": ["However", ",", "the", "role", "of", "the", "enzyme", "phospholipase", "A2", "C1706169#ent", "<e1>", ")", ",", "which", "hydrolyses", "surfactant", "in", "adult", "respiratory", "distress", "syndrome", "C0243025#ent", "<e2>", ")", ",", "has", "not", "yet", "been", "studied", "."], "h": {"id": "C1706169", "name": "C1706169#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243025", "name": "C0243025#ent", "pos": [21, 22]}}
{"token": ["These", "data", "show", "that", "strain", "as", "well", "as", "C2936882#ent", "<e1>", "stimulates", "increased", "proliferation", "in", "C0289313#ent", "<e2>", "17/2.8", "cells", "and", "increased", "ER", "alpha-related", "ERE", "activity", "in", "ROS", "cells", "transfected", "with", "ER", "alpha"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [14, 15]}}
{"token": ["\"", "C1414506#ent", "<e1>", "PAR-2", ")", "is", "a", "G", "protein-coupled", "transmembrane", "receptor", "seven", "transmembrane", "domains", "activated", "by", "C0960371#ent", "<e2>", "."], "h": {"id": "C1414506", "name": "C1414506#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [16, 17]}}
{"token": ["We", "evaluated", "the", "contribution", "of", "rab5a", "and", "rab11a", "to", "trafficking", "and", "signaling", "of", "C1414506#ent", "<e1>", "PAR2", ")", ",", "a", "receptor", "for", "C0960371#ent", "<e2>", "and", "tryptase", "."], "h": {"id": "C1414506", "name": "C1414506#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [21, 22]}}
{"token": ["RSV", "disease", "is", "associated", "with", "C0001883#ent", "<e1>", "AO", ")", ",", "long-term", "airway", "hyperresponsiveness", "AHR", ")", ",", "and", "C3714636#ent", "<e2>"], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [17, 18]}}
{"token": ["A", "48", "year", "old", "male", "patient", "presented", "with", "maculopapular", "rash", "pruritus", ",", "C0030920#ent", "<e1>", "attacks", "of", "headache", "and", "C0042571#ent", "<e2>", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042571", "name": "C0042571#ent", "pos": [18, 19]}}
{"token": ["Overexpression", "above", "endogenous", "levels", "of", "C1333258#ent", "<e1>", "led", "to", "accelerated", "C1366882#ent", "<e2>", "inactivation", ",", "but", "did", "not", "alter", "the", "normal", "activation", "of", "C1366882#ent", "<e2>", "."], "h": {"id": "C1333258", "name": "C1333258#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366882", "name": "C1366882#ent", "pos": [10, 11]}}
{"token": ["Five", "French", "cider", "apple", "varieties", "were", "compared", "on", "the", "basis", "of", "their", "detailed", "C0071649#ent", "<e1>", "profile", "in", "the", "C0001614#ent", "<e2>", "and", "in", "the", "juices", "."], "h": {"id": "C0071649", "name": "C0071649#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [18, 19]}}
{"token": ["Resistance", "to", "thyroid", "hormone", "RTH", ")", "is", "a", "C0039082#ent", "<e1>", "in", "which", "patients", "have", "elevated", "thyroid", "hormone", "C1420718#ent", "<e2>", ")", "levels", "and", "decreased", "sensitivity", "to", "its", "action", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [17, 18]}}
{"token": ["In", "many", "patients", "GERD", "is", "associated", "with", "or", "atypical", "manifestations", ",", "including", "C0010200#ent", "<e1>", ",", "asthma", ",", "laryngitis", "or", "C0476281#ent", "<e2>"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0476281", "name": "C0476281#ent", "pos": [19, 20]}}
{"token": ["C4025182#ent", "<e1>", "GH", "response", "may", "not", "be", "mediated", "by", "C1333674#ent", "<e2>", "."], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333674", "name": "C1333674#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "treatment", "of", "infected", "Sf9", "cells", "expressing", "the", "wild-type", "cPLA2", "with", "phorbol", "12-tetradecanoate", "13-acetate", "C0256103#ent", "<e1>", ")", "shifted", "all", "of", "the", "C3889446#ent", "<e2>", "cPLA2", "to", "the", "phosphorylated", "Ser-505", "form", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [22, 23]}}
{"token": ["N-Linked", "glycans", "from", "C0035541#ent", "<e1>", "chicken", "ovalbumin", "bovine", "fetuin", ",", "C1420709#ent", "<e2>", "human", "alpha(1)-acid", "glycoprotein", "were", "derivatized", "with", "2-aminobenzoic", "acid", "reductive", "amination", "and", "their", "tandem", "mass", "spectra", "recorded", "by", "negative", "ion", "electrospray", "ionization", "a", "quadrupole", "time-of-flight", "mass", "spectrometer"], "h": {"id": "C0035541", "name": "C0035541#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [10, 11]}}
{"token": ["We", "identified", "a", "patient", "with", "C0268165#ent", "<e1>", "PH2", ")", "showing", "recurrent", "stone", "formation", ",", "C0027709#ent", "<e2>", ",", "end-stage", "renal", "failure", "and", "rapid", "oxalate", "deposition", "after", "renal", "transplantation", "a", "living", "related", "donor", "."], "h": {"id": "C0268165", "name": "C0268165#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0027709", "name": "C0027709#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", "the", "anticholinergic", "drug", "C0003830#ent", "<e1>", ",", "at", "low", "doses", "administered", "chronically", "for", "one", "month", "to", "C0030567#ent", "<e2>", "patients", "caused", "a", "decrease", "in", "performance", "on", "recent", "but", "not", "immediate", "memory", "tests"], "h": {"id": "C0003830", "name": "C0003830#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [18, 19]}}
{"token": ["C0032238#ent", "<e1>", "are", "accompanied", "by", "synovitis", "and", "C0006444#ent", "<e2>", "of", "the", "large", "proximal", "joints", "can", "be", "visualized", "by", "ultrasound", "or", "magnetic", "resonance", "imaging"], "h": {"id": "C0032238", "name": "C0032238#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006444", "name": "C0006444#ent", "pos": [7, 8]}}
{"token": ["In", "this", "review", ",", "we", "discuss", "the", "role", "of", "C0623362#ent", "<e1>", "the", "potential", "therapeutic", "inhibition", "of", "metalloproteinases", "in", "C0948780#ent", "<e2>"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0948780", "name": "C0948780#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "C0041260#ent", "<e1>", "inhibited", "activity", "while", "L-tyrosine", ",", "L-methionine", ",", "C0281255#ent", "<e2>", "and", "L-isoleucine", "activated", "the", "enzyme", "."], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0281255", "name": "C0281255#ent", "pos": [11, 12]}}
{"token": ["We", "assumed", "that", "C0050559#ent", "<e1>", "reduced", "dermal", "thickness", "and", "suppressed", "the", "appearance", "of", "C0037284#ent", "<e2>", "inducting", "apoptosis", "and", "perhaps", "regulation", "of", "cytokine", "expression", "."], "h": {"id": "C0050559", "name": "C0050559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [13, 14]}}
{"token": ["Garlic", "oil", "300", "and", "3,000", "mg/L", ")", "and", "C0036075#ent", "<e1>", "300", "and", "3,000", "mg/L", ")", "reduced", "C0000975#ent", "<e2>", "and", "increased", "propionate", "and", "butyrate", "proportions", ",", "suggesting", "that", "methane", "production", "was", "inhibited", "."], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [16, 17]}}
{"token": ["It", "is", "likely", "that", "our", "patients", "represent", "a", "variant", "form", "of", "the", "C0039082#ent", "<e1>", "originally", "described", "by", "C0004775#ent", "<e2>", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0004775", "name": "C0004775#ent", "pos": [17, 18]}}
{"token": ["A", "new", "C0039082#ent", "<e1>", ",", "characterized", "by", "C0004775#ent", "<e2>", "hyperreninemia", ",", "aldosterone", ",", "high", "urinary", "prostaglandin", "E2", "excretion", ",", "normal", "BP", "and", "resistance", "of", "BP", "to", "angiotensin", "II", "described", "in", "three", "of", "four", "siblings", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0004775", "name": "C0004775#ent", "pos": [7, 8]}}
{"token": ["The", "human", "C2827561#ent", "<e1>", "a", "key", "role", "in", "the", "C1710463#ent", "<e2>", "the", "beta-globin", "locus", "comprises", "four", "erythroid", "specific", "DNase", "I", "hypersensitive", "sites", "designated", "5'HS1", "-", "4", "."], "h": {"id": "C2827561", "name": "C2827561#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [9, 10]}}
{"token": ["These", "analyses", "did", "not", "provide", "any", "evidences", "that", "these", "C1417679#ent", "<e1>", "are", "responsible", "for", "the", "C0270853#ent", "<e2>", "phenotype", ",", "and", "suggested", "that", "these", "may", "not", "be", "the", "EJM1", "gene", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0270853", "name": "C0270853#ent", "pos": [15, 16]}}
{"token": ["BIT", ",", "but", "not", "PIR-B", ",", "is", "in", "a", "complex", "with", "the", "colony-stimulating", "factor", "1", "receptor", "C1706382#ent", "<e1>", ")", ",", "suggesting", "that", "BIT", "may", "direct", "C1705637#ent", "<e2>", "to", "the", "C1706382#ent", "<e1>", "."], "h": {"id": "C1705637", "name": "C1705637#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1706382", "name": "C1706382#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "C0142529#ent", "<e1>", "6-chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine", ")", ",", "a", "potent", "and", "selective", "C2746076#ent", "<e2>", "on", "blood", "pressure", "heart", "rate", "examined", "in", "normotensive", "and", "hypertensive", "rats", "."], "h": {"id": "C0142529", "name": "C0142529#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2746076", "name": "C2746076#ent", "pos": [12, 13]}}
{"token": ["The", "highly", "conserved", "33", "kDa", "amino-terminal", "domain", "C1423112#ent", "<e1>", "plays", "a", "critical", "role", "in", "binding", "to", "C4277588#ent", "<e2>", "and", "in", "regulating", "the", "clathrin", "assembly", "activity", "of", "C1423112#ent", "<e1>", "."], "h": {"id": "C4277588", "name": "C4277588#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1423112", "name": "C1423112#ent", "pos": [7, 8]}}
{"token": ["Proteins", "dissolved", "in", "low-conductivity", "media", "stacked", "in", "both", "C0077025#ent", "<e1>", "buffers", "and", "in", "C0032483#ent", "<e2>", "solutions", "."], "h": {"id": "C0077025", "name": "C0077025#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [13, 14]}}
{"token": ["These", "data", "strongly", "indicate", "that", "ALS2CR1", ",", "ALS2CR2", ",", "ALS2CR3", ",", "CFLAR", ",", "C1667078#ent", "<e1>", ",", "and", "CASP8", "are", "not", "causative", "genes", "C1859807#ent", "<e2>", "."], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1859807", "name": "C1859807#ent", "pos": [22, 23]}}
{"token": ["Seven", "patients", "with", "the", "reversible", "type", "were", "given", "25", "mg", "C0885449#ent", "<e1>", "daily", "for", "2", "-", "4", "weeks", ";", "all", "became", "C0271801#ent", "<e2>", "again", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0271801", "name": "C0271801#ent", "pos": [21, 22]}}
{"token": ["The", "influence", "of", "the", "benzodiazepine", "(", "BZ", ")", "receptor", "antagonist", "Ro", "15", "-", "1788", "on", "the", "C0003286#ent", "<e1>", "properties", "of", "C0016375#ent", "<e2>", "(", "FLZ", ")", "was", "studied", "in", "rats", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0016375", "name": "C0016375#ent", "pos": [20, 21]}}
{"token": ["Self-reactive", "B-cell", "immunity", "to", "C1415782#ent", "<e1>", "may", "contribute", "to", "C0008149#ent", "<e2>", "pathogenesis", "."], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008149", "name": "C0008149#ent", "pos": [9, 10]}}
{"token": ["Several", "experimental", "primers", "prepared", "by", "dilution", "of", "C0007026#ent", "<e1>", "or", "their", "esterified", "salts", "with", "different", "ratios", "of", "C0067666#ent", "<e2>", "to", "obtain", "ratios", "of", "5", "%", "and", "35", "%", "by", "weight", "."], "h": {"id": "C0007026", "name": "C0007026#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0067666", "name": "C0067666#ent", "pos": [17, 18]}}
{"token": ["Interactions", "of", "D-penicillamine", "with", "various", "antacids", "(", "C2930042#ent", "<e1>", "AH-MH", ";", "aluminum", "hydroxide-calcium", "carbonate", ",", "AH-CC", ";", "C0058135#ent", "<e2>", "DSAC", ";", "aluminum", "hydroxide", "AH", ")", "were", "studied", "in", "vitro"], "h": {"id": "C2930042", "name": "C2930042#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0058135", "name": "C0058135#ent", "pos": [17, 18]}}
{"token": ["The", "findings", "suggest", "that", "the", "erythrocyte", "C1704945#ent", "<e1>", ",", "catalase", ",", "and", "C2939465#ent", "<e2>", "can", "undergo", "an", "adaptive", "alteration", "however", "appears", "reversible", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2939465", "name": "C2939465#ent", "pos": [12, 13]}}
{"token": ["Isolated", "epithelial", "cells", "low", "activities", "of", "these", "C0031727#ent", "<e1>", ",", "but", "a", "high", "activity", "of", "C1366499#ent", "<e2>", "which", "may", "reflect", "an", "exclusively", "basolateral", "localization", "the", "latter", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366499", "name": "C1366499#ent", "pos": [15, 16]}}
{"token": ["Because", "C0812245#ent", "<e1>", "also", "interacts", "with", "p53", "and", "C4042483#ent", "<e2>", "and", "regulates", "p53", "function", ",", "our", "results", "suggest", "that", "APCL", "might", "be", "involved", "in", "the", "p53/Bcl2-linked", "pathway", "of", "cell-cycle", "progression", "cell", "death"], "h": {"id": "C0812245", "name": "C0812245#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4042483", "name": "C4042483#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "report", "that", "the", "C0063465#ent", "<e1>", "AQ4N", "is", "reduced", "by", "a", "C0132555#ent", "<e2>"], "h": {"id": "C0063465", "name": "C0063465#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [13, 14]}}
{"token": ["A", "cDNA", "encoding", "a", "5'-nucleotidase", "was", "identified", "by", "screening", "a", "lambda", "gt10", "cDNA", "library", "the", "electric", "lobe", "Discopyge", "ommata", "using", "a", "cDNA", "probe", "the", "complete", "C0079941#ent", "<e1>", "the", "rat", "C0443764#ent", "<e2>"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0443764", "name": "C0443764#ent", "pos": [29, 30]}}
{"token": ["Using", "dominant", "negative", "expression", "vectors", "siRNA", "interference", ",", "we", "demonstrate", "that", "LPS", "induces", "C1333571#ent", "<e1>", "activation", "via", "C2983365#ent", "<e2>", ",", "TRAF6", ",", "ERK1/2", ",", "and", "JNK", "signaling", "pathways"], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2983365", "name": "C2983365#ent", "pos": [17, 18]}}
{"token": ["CYP102A2", "is", "a", "catalytically", "self-sufficient", "cytoplasmic", "enzyme", "Bacillus", "subtilis", "containing", "both", "a", "C0066083#ent", "<e1>", "a", "reductase", "domain", "a", "C1305923#ent", "<e2>"], "h": {"id": "C0066083", "name": "C0066083#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [18, 19]}}
{"token": ["Protein", "kinase", "C", "C1562036#ent", "<e1>", "however", ",", "blocked", "the", "effects", "of", "C1705889#ent", "<e2>", "on", "the", "receptor", "resensitized", "by", "enalaprilat", "or", "ramiprilat", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705889", "name": "C1705889#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "we", "found", "that", "CARP", "was", "not", "expressed", "in", "C0017665#ent", "<e1>", "evidently", "expressed", "in", "most", "cases", "of", "C4054543#ent", "<e2>"], "h": {"id": "C0017665", "name": "C0017665#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C4054543", "name": "C4054543#ent", "pos": [18, 19]}}
{"token": ["Concurrent", "C1334103#ent", "<e1>", "be", "an", "important", "underlying", "cause", "of", "sleep", "impairment", "C0004096#ent", "<e2>", "patients", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [1, 2]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [11, 12]}}
{"token": ["Fourteen", "bulls", "had", "C0029410#ent", "<e1>", "3", "had", "osteochondrosis", "(", "C3665488#ent", "<e2>", "of", "the", "distal", "end", "of", "the", "femur", "."], "h": {"id": "C0029410", "name": "C0029410#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C3665488", "name": "C3665488#ent", "pos": [9, 10]}}
{"token": ["A", "total", "of", "437", "C0011175#ent", "<e1>", "children", "aged", "less", "than", "five", "years", "presenting", "to", "health", "centres", "C0011991#ent", "<e2>", "randomly", "assigned", "to", "the", "three", "ORS", "groups", "."], "h": {"id": "C0011175", "name": "C0011175#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [16, 17]}}
{"token": ["Because", "NF-kappaB", "is", "known", "to", "mediate", "the", "development", "of", "C1442864#ent", "<e1>", "we", "examined", "the", "association", "between", "the", "C1539897#ent", "<e2>", "M55V", "variant", "and", "the", "severity", "of", "C1442864#ent", "<e1>"], "h": {"id": "C1442864", "name": "C1442864#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1539897", "name": "C1539897#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "we", "concluded", "that", "other", "proteins", ",", "in", "addition", "to", "C1414357#ent", "<e1>", ",", "must", "be", "involved", "in", "C0719341#ent", "<e2>", "adherence", ",", "possibly", "in", "combination", "with", "C1414357#ent", "<e1>", "."], "h": {"id": "C0719341", "name": "C0719341#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414357", "name": "C1414357#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "we", "performed", "a", "review", "and", "meta-analysis", "of", "reported", "associations", "between", "the", "imprinting", "status", "the", "C1416613#ent", "<e1>", "and", "H19", "genes", "the", "risk", "for", "tumor", "development", "C1706028#ent", "<e2>", "."], "h": {"id": "C1416613", "name": "C1416613#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706028", "name": "C1706028#ent", "pos": [26, 27]}}
{"token": ["With", "the", "exception", "of", "CoxB", "and", "CoxK", ",", "all", "deduced", "products", "of", "the", "C0033551#ent", "<e1>", "O.", "carboxidovorans", "have", "counterparts", "in", "so", "far", "uncharacterized", "C0017258#ent", "<e2>", "Pseudomonas", "thermocarboxydovorans", "Hydrogenophaga", "pseudoflava", "Bradyrhizobium", "japonicum", "and", "Mycobacterium", "tuberculosis"], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017258", "name": "C0017258#ent", "pos": [23, 24]}}
{"token": ["C1709246#ent", "<e1>", "up", "about", "6", "%", "of", "C0012634#ent", "<e2>", "of", "the", "salivary", "glands"], "h": {"id": "C1709246", "name": "C1709246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [7, 8]}}
{"token": ["C0013423#ent", "<e1>", "dt", ")", "is", "a", "mutant", "mouse", "with", "C0027888#ent", "<e2>"], "h": {"id": "C0013423", "name": "C0013423#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027888", "name": "C0027888#ent", "pos": [9, 10]}}
{"token": ["A", "novel", "dihydrolipoyl", "dehydrogenase-binding", "protein", "E3BP", ")", "which", "lacks", "an", "amino-terminal", "lipoyl", "domain", ",", "C0534519#ent", "<e1>", ",", "has", "been", "identified", "in", "the", "C0034344#ent", "<e2>", "PDC", ")", "of", "the", "adult", "parasitic", "nematode", "Ascaris", "suum"], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0034344", "name": "C0034344#ent", "pos": [22, 23]}}
{"token": ["There", "is", "little", "similarity", "among", "the", "sequences", "upstream", "from", "the", "CAP", "site", "of", "the", "C1419241#ent", "<e1>", "genes", "except", "the", "TATA", "consensus", "sequence", "a", "repeating", "trinucleotide", "C3890007#ent", "<e2>", "."], "h": {"id": "C1419241", "name": "C1419241#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3890007", "name": "C3890007#ent", "pos": [25, 26]}}
{"token": ["Caspofungin", "(", "MK-0991", ";", "C1138840#ent", "<e1>", ")", "belongs", "to", "the", "echinocandin", "family", "a", "new", "class", "of", "C0003308#ent", "<e2>", "act", "on", "the", "fungal", "cell", "wall", "inhibiting", "glucan", "synthesis", "."], "h": {"id": "C1138840", "name": "C1138840#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [16, 17]}}
{"token": ["Ectopic", "expression", "of", "KSR", "inhibited", "the", "activation", "of", "ERK", "C0170168#ent", "<e1>", "insulin", ",", "phorbol", "ester", "or", "activated", "C0002085#ent", "<e2>", "of", "Ras", ",", "Raf", ",", "and", "mitogen", "and", "extracellular-regulated", "kinase"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [17, 18]}}
{"token": ["The", "best", "single", "indicator", "of", "a", "potent", "renal", "mechanism", "the", "C0020437#ent", "<e1>", "and", "also", "a", "poor", "response", "C0043603#ent", "<e2>", "was", "a", "low", "renal", "phosphate", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0043603", "name": "C0043603#ent", "pos": [17, 18]}}
{"token": ["The", "orientation", "of", "the", "poly[6-methacryloyloxyhexyl", "phosphorylcholine", "(", "C0063242#ent", "<e1>", ")", "]", "which", "has", "six", "C0054666#ent", "<e2>", "the", "phospholipid", "polar", "group", "the", "backbone", "was", "higher", "than", "that", "of", "other", "poly(MAPC)s", "."], "h": {"id": "C0063242", "name": "C0063242#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0054666", "name": "C0054666#ent", "pos": [14, 15]}}
{"token": ["Epidemiological", "situation", "C0036918#ent", "<e1>", "unfavourably", "due", "to", "growth", "of", "cases", "C1260915#ent", "<e2>", "early", "and", "tarda", ")", "in", "Poland", "."], "h": {"id": "C0036918", "name": "C0036918#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1260915", "name": "C1260915#ent", "pos": [10, 11]}}
{"token": ["Glucose", "as", "well", "as", "the", "fungal", "elicitor", "chitosan", ",", "the", "C0597217#ent", "<e1>", "endothall", ",", "and", "C1161334#ent", "<e2>", "shown", "to", "result", "in", "a", "coordinated", "regulatory", "mechanism"], "h": {"id": "C0597217", "name": "C0597217#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1161334", "name": "C1161334#ent", "pos": [15, 16]}}
{"token": ["Three", "potential", "inhibitors", "of", "C0035379#ent", "<e1>", "phosphonoformate", "(", "PF", ")", ",", "phosphonoacetate", "(", "C0267964#ent", "<e2>", ")", ",", "and", "ethyl-diethyl", "phosphonoformate", "(", "Et-PF", ")", ",", "were", "compared", "in", "this", "study", "."], "h": {"id": "C0035379", "name": "C0035379#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0267964", "name": "C0267964#ent", "pos": [13, 14]}}
{"token": ["K562/TPA", "showed", "cross-resistance", "to", "etoposide", ",", "teniposide", ",", "adriamycin", "(", "C0215825#ent", "<e1>", ")", ",", "vincristine", ",", "vindesine", "and", "3-[(4-amino-2-methyl-5-pyrimidinyl", ")", "]", "C0059035#ent", "<e2>", ",", "but", "showed", "collateral", "sensitivity", "cisplatin", "."], "h": {"id": "C0215825", "name": "C0215825#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0059035", "name": "C0059035#ent", "pos": [21, 22]}}
{"token": ["Core", "members", "the", "MBD", "protein", "family", "MeCP2", ",", "C1414134#ent", "<e1>", ",", "MBD2", "and", "MBD4", ")", "share", "a", "C2986645#ent", "<e2>", "has", "a", "specific", "affinity", "for", "methylated", "CpG", "sites", "in", "double-stranded", "DNA"], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2986645", "name": "C2986645#ent", "pos": [17, 18]}}
{"token": ["C0035579#ent", "<e1>", "and", "osteomalacia", "is", "a", "C0025517#ent", "<e2>", "to", "a", "mineralization", "defect", "principal", "pathophysiology"], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [6, 7]}}
{"token": ["The", "PKD2-mediated", "AP-1", "activity", "was", "dependent", "upon", "activation", "of", "the", "mitogen-activated", "protein", "kinases", "p38", "C1367731#ent", "<e1>", "and", "protein", "kinase", "C", "PKC", ")", "epsilon", ",", "a", "calcium-independent", "PKC", "C1412365#ent", "<e2>", "."], "h": {"id": "C1367731", "name": "C1367731#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412365", "name": "C1412365#ent", "pos": [27, 28]}}
{"token": ["The", "high", "activity", "of", "C0052908#ent", "<e1>", "make", "the", "expression", "system", "powerful", "for", "high-level", "expression", "of", "the", "C0034861#ent", "<e2>"], "h": {"id": "C0052908", "name": "C0052908#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [16, 17]}}
{"token": ["Variants", "in", "the", "C1415046#ent", "<e1>", "suggestive", "evidence", "of", "an", "association", "with", "C0011881#ent", "<e2>", "African-American", "individuals", ",", "and", "increased", "GFPT1", "gene", "expression", "characterize", "Caucasian", "subjects", "with", "C0011881#ent", "<e2>"], "h": {"id": "C1415046", "name": "C1415046#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [11, 12]}}
{"token": ["The", "sequences", "of", "these", "C0030956#ent", "<e1>", "were", "not", "found", "in", "the", "primary", "sequence", "C0812443#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [13, 14]}}
{"token": ["The", "study", "included", "34", "patients", "(", "aged", "0.1", "-", "14", "years", ")", "with", "C0859681#ent", "<e1>", "7", "of", "whom", "already", "had", "C0035078#ent", "<e2>"], "h": {"id": "C0859681", "name": "C0859681#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "reconstitution", "of", "recombinant", "PLC", "protein", "into", "C0031669#ent", "<e1>", "beta3-deficient", "dorsal", "root", "ganglion", "neurons", "reduced", "DAMGO", "responses", "to", "those", "of", "C2987364#ent", "<e2>", "neurons", "."], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [22, 23]}}
{"token": ["Felbamate", "was", "also", "the", "first", "C0013227#ent", "<e1>", "to", "be", "tested", "in", "a", "placebo-controlled", "trial", "children", "with", "the", "C0238111#ent", "<e2>"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [17, 18]}}
{"token": ["Assay", "of", "C1442485#ent", "<e1>", ",", "heparin", "sulphamidase", ",", "N-acetyl-alpha-D-glucosaminidase", ",", "C0003940#ent", "<e2>", "alpha-L-fucosidase", ",", "beta-glucuronidase", ",", "beta-galactosidase", "and", "alpha-D-mannosidase", "in", "cultured", "cells", "described", "."], "h": {"id": "C1442485", "name": "C1442485#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003940", "name": "C0003940#ent", "pos": [10, 11]}}
{"token": ["Human", "C0040896#ent", "<e1>", "is", "a", "potentially", "severe", "C0747256#ent", "<e2>", "after", "ingestion", "of", "undercooked", "meat", "infected", "with", "Trichinella", "sp.", "larvae"], "h": {"id": "C0040896", "name": "C0040896#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [7, 8]}}
{"token": ["A", "5-year-old", "boy", "had", "recurrent", "vomiting", "and", "C0023380#ent", "<e1>", "with", "lacticacidemia", "and", "C0024776#ent", "<e2>", "since", "birth", "."], "h": {"id": "C0023380", "name": "C0023380#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0024776", "name": "C0024776#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "Ca2", "+", "channel", "blockers", "diltiazem", ",", "C0028066#ent", "<e1>", "and", "amlodipine", "were", "investigated", "on", "both", "C0020538#ent", "<e2>", "myocardial", "changes", "induced", "by", "chronic", "blockade", "nitric", "oxide", "synthesis", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [17, 18]}}
{"token": ["This", "study", "was", "undertaken", "to", "determine", "the", "acute", "effects", "of", "C0028066#ent", "<e1>", "on", "left", "ventricular", "filling", "examined", "by", "Doppler", "echocardiography", "patients", "with", "C0020538#ent", "<e2>", "normal", "left", "ventricular", "systolic", "function"], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [22, 23]}}
{"token": ["We", "also", "characterized", "the", "heme", "electronic", "structure", "the", "cyanide", "adducts", "the", "proteins", ",", "where", "the", "axial", "C1822773#ent", "<e1>", "was", "replaced", "by", "an", "exogenous", "C0056650#ent", "<e2>", "through", "the", "analysis", "of", "(1)H", "NMR", "spectra", "."], "h": {"id": "C1822773", "name": "C1822773#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0056650", "name": "C0056650#ent", "pos": [23, 24]}}
{"token": ["Preliminary", "data", "suggest", "that", "the", "combination", "is", "not", "limited", "only", "to", "celecoxib", "and", "that", "addition", "of", "C4055175#ent", "<e1>", "to", "other", "C0003211#ent", "<e2>", "such", "as", "sulindac", ",", "synergistically", "augments", "neoplastic", "cell", "growth", "inhibition", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [20, 21]}}
{"token": ["C1257960#ent", "<e1>", "is", "an", "extremely", "rare", "C0019247#ent", "<e2>", "by", "a", "deficiency", "of", "the", "lysosomal", "enzyme", "alpha-mannosidase", "."], "h": {"id": "C1257960", "name": "C1257960#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [6, 7]}}
{"token": ["Co-stimulator", "blockade", "trans", "inhibitory", ",", "using", "C0035064#ent", "<e1>", "such", "as", "CTLA-4-Ig", "and", "Fas", "ligand", "C1706006#ent", "<e2>", ")", "respectively", "have", "been", "invoked", "as", "alternative", "strategies", "for", "suppressing", "pathogenic", "T", "cells"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [14, 15]}}
{"token": ["The", "ability", "of", "these", "C0035064#ent", "<e1>", "to", "induce", "C1706006#ent", "<e2>", "expression", "correlated", "with", "their", "ability", "to", "cause", "DNA", "damage"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [8, 9]}}
{"token": ["We", "propose", "that", "C1708018#ent", "<e1>", "is", "the", "previously", "observed", "C0024530#ent", "<e2>", "exflagellation", "factor", "(", "MEF", ")", "."], "h": {"id": "C1708018", "name": "C1708018#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [9, 10]}}
{"token": ["To", "review", "the", "use", "of", "C0011816#ent", "<e1>", "for", "the", "treatment", "of", "C0751074#ent", "<e2>"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751074", "name": "C0751074#ent", "pos": [11, 12]}}
{"token": ["Under", "anaerobic", "conditions", ",", "C0033405#ent", "<e1>", "degraded", "only", "in", "the", "presence", "of", "copper", "(", "C3273406#ent", "<e2>", ")", "and", "iorn", "(", "III", ")", "ions", "."], "h": {"id": "C0033405", "name": "C0033405#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [14, 15]}}
{"token": ["The", "eruption", "usually", "occurs", "in", "individuals", "with", "atopic", "dermatitis", "other", "pre-existing", "C0037274#ent", "<e1>", "such", "as", "C0017925#ent", "<e2>", "pemphigus", "foliaceus", "mycosis", "fungoides", "Sezary", "syndrome", "benign", "familial", "pemphigus", "ichthyosis", "vulgaris", "second-degree", "burns", "multiple", "myeloma", "and", "Grover's", "disease"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017925", "name": "C0017925#ent", "pos": [15, 16]}}
{"token": ["Recently", ",", "we", "reported", "that", "there", "is", "immunological", "similarity", "between", "the", "C1334133#ent", "<e1>", "pp60src", "[", "the", "protein", "encoded", "by", "the", "C3853557#ent", "<e2>", "Rous", "sarcoma", "virus", "RSV", ")", "]", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3853557", "name": "C3853557#ent", "pos": [20, 21]}}
{"token": ["Neither", "insulin", "nor", "C0037501#ent", "<e1>", "stimulated", "glucose", "disappearance", "after", "functional", "hepatectomy", ",", "but", "both", "C0991617#ent", "<e2>", "decreased", "the", "accumulation", "in", "blood", "of", "lactate", ",", "pyruvate", "and", "alanine", "."], "h": {"id": "C0037501", "name": "C0037501#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [14, 15]}}
{"token": ["Comparison", "of", "the", "predicted", "amino", "acid", "sequence", "v-raf", "with", "the", "predicted", "C2917660#ent", "<e1>", "of", "other", "oncogenes", "reveals", "significant", "homologies", "to", "the", "C0282625#ent", "<e2>", "oncogenes", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [21, 22]}}
{"token": ["Activation", "of", "C1312419#ent", "<e1>", "PKCbeta", ")", "has", "been", "repeatedly", "implicated", "in", "C1274103#ent", "<e2>", "angiogenesis", "."], "h": {"id": "C1312419", "name": "C1312419#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1274103", "name": "C1274103#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "interaction", "between", "these", "two", "pathways", "using", "normal", "mesangial", "cells", "MCs", ")", "and", "transgenic", "(", "C1420709#ent", "<e1>", ")", "MCs", "with", "elevated", "C1412322#ent", "<e2>", "AR", ")", "activity", "."], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1412322", "name": "C1412322#ent", "pos": [23, 24]}}
{"token": ["A", "part", "of", "the", "sequence", "which", "showed", "the", "highest", "similarity", "to", "C1332721#ent", "<e1>", "turned", "out", "to", "be", "identical", "to", "the", "C0080054#ent", "<e2>", "Cdk", ")", "cDNA", "fragment", "isolated", "by", "degenerate", "RT-PCR", "."], "h": {"id": "C1332721", "name": "C1332721#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [20, 21]}}
{"token": ["Expression", "of", "Dm", "cdc2", "Schizosaccharomyces", "pombe", "Saccharomyces", "cerevisiae", "cell", "cycle", "arrest", "by", "mutations", "in", "C1332721#ent", "<e1>", "+", "and", "CDC28", ",", "the", "genes", "encoding", "the", "C0080054#ent", "<e2>", "of", "these", "yeasts", "."], "h": {"id": "C1332721", "name": "C1332721#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [24, 25]}}
{"token": ["The", "C0027203#ent", "<e1>", "was", "therefore", "designated", "as", "4-amino-3-hydroxybenzoate", "C0041256#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041256", "name": "C0041256#ent", "pos": [8, 9]}}
{"token": ["The", "murine", "C3273595#ent", "<e1>", "(", "Pnutl1", ")", "gene", "belongs", "to", "the", "family", "of", "C1539748#ent", "<e2>", ",", "which", "are", "thought", "to", "be", "involved", "in", "cytokinesis", "in", "yeast", ",", "Drosophila", "and", "vertebrates", "."], "h": {"id": "C3273595", "name": "C3273595#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1539748", "name": "C1539748#ent", "pos": [13, 14]}}
{"token": ["The", "murine", "Cdcrel-1", "(", "C3273595#ent", "<e1>", ")", "gene", "belongs", "to", "the", "family", "of", "C1539748#ent", "<e2>", ",", "which", "are", "thought", "to", "be", "involved", "in", "cytokinesis", "in", "yeast", ",", "Drosophila", "and", "vertebrates", "."], "h": {"id": "C3273595", "name": "C3273595#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1539748", "name": "C1539748#ent", "pos": [13, 14]}}
{"token": ["In", "detergent", "extracts", "C3273595#ent", "<e1>", "and", "another", "C1539748#ent", "<e2>", ",", "Nedd5", ",", "immunoprecipitated", "with", "the", "SNARE", "protein", "by", "directly", "binding", "to", "syntaxin", "via", "the", "SNARE", "interaction", "domain"], "h": {"id": "C3273595", "name": "C3273595#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1539748", "name": "C1539748#ent", "pos": [7, 8]}}
{"token": ["The", "clone", "included", "58", "%", "of", "the", "open", "reading", "frame", "C0033551#ent", "<e1>", "well", "as", "that", "for", "the", "adjacent", "C0036843#ent", "<e2>", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036843", "name": "C0036843#ent", "pos": [18, 19]}}
{"token": ["The", "cells", "in", "the", "zona", "intermedia", "did", "not", "express", "C3274855#ent", "<e1>", ",", "aldosterone", "synthase", "or", "11", "beta-hydroxylase", ",", "but", "did", "express", "C1417838#ent", "<e2>", "."], "h": {"id": "C3274855", "name": "C3274855#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417838", "name": "C1417838#ent", "pos": [21, 22]}}
{"token": ["Reports", "of", "arrhythmogenic", "effects", "(", "C0040479#ent", "<e1>", "related", "to", "C0770909#ent", "<e2>", "led", "to", "the", "assembly", "of", "a", "task", "force", "physicians", "from", "France", "and", "the", "Netherlands", "."], "h": {"id": "C0040479", "name": "C0040479#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0770909", "name": "C0770909#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "the", "significantly", "higher", "C1705340#ent", "<e1>", "levels", "in", "the", "C1540289#ent", "<e2>", "group", "might", "result", "in", "hypovitaminosis", "D.", "In", "conclusion", ",", "evidence", "of", "hypovitaminosis", "D", "the", "patients", "with", "mitral", "ring", "calcification", "demonstrated", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1540289", "name": "C1540289#ent", "pos": [10, 11]}}
{"token": ["When", "C0282210#ent", "<e1>", "was", "infused", "during", "C0016229#ent", "<e2>", "treatment", ",", "complete", "anterograde", "(", "3", "patients", ")", "or", "retrograde", "block", "2", "patients", ")", "persisted", "in", "the", "accessory", "pathway.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0016229", "name": "C0016229#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "uncoupling", "of", "MLA6-specific", "function", "from", "C3811749#ent", "<e1>", "also", "uncoupled", "the", "response", "from", "C1424675#ent", "<e2>", ",", "a", "protein", "known", "to", "associate", "physically", "with", "C3811749#ent", "<e1>", "."], "h": {"id": "C1424675", "name": "C1424675#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3811749", "name": "C3811749#ent", "pos": [7, 8]}}
{"token": ["We", "describe", "a", "14-year-old", "boy", "who", "was", "severely", "C3714552#ent", "<e1>", "by", "the", "C4287919#ent", "<e2>", "associated", "with", "vitamin", "E", "deficiency", "secondary", "to", "chronic", "cholestatic", "liver", "disease"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4287919", "name": "C4287919#ent", "pos": [12, 13]}}
{"token": ["The", "C1418591#ent", "<e1>", "fraction", "also", "had", "a", "C1334291#ent", "<e2>", "molecule", ",", "Jak2", ",", "believed", "to", "phosphorylate", "Stat3", "."], "h": {"id": "C1418591", "name": "C1418591#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334291", "name": "C1334291#ent", "pos": [7, 8]}}
{"token": ["C0012544#ent", "<e1>", ",", "such", "as", "disodium-1-hydroxy-1-aminopropylidine-1,1-diphosphonate", "(", "APD", ")", "and", "C0015121#ent", "<e2>", "(", "HEBP", ")", ",", "at", "increased", "concentrations", ",", "inhibited", "ALP", "amino", "acid", "phosphatase", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0015121", "name": "C0015121#ent", "pos": [10, 11]}}
{"token": ["C0012544#ent", "<e1>", "such", "as", "disodium-1-hydroxy-1-aminopropylidine-1,1-diphosphonate", "(", "APD", ")", "and", "C0015121#ent", "<e2>", "HEDP", ")", "inhibited", "ALP", "phosphate", "ester", "hydrolysis", "activity", "more", "than", "PPase", "activity", "the", "same", "concentrations", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0015121", "name": "C0015121#ent", "pos": [9, 10]}}
{"token": ["Finally", ",", "increasing", "the", "C1161331#ent", "<e1>", "content", "of", "the", "diet", "increases", "the", "incidence", "of", "C2711227#ent", "<e2>"], "h": {"id": "C1161331", "name": "C1161331#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "TReP-132", "knockdown", "resulted", "in", "enhanced", "cell", "proliferation", "lowered", "p21", "and", "C1420433#ent", "<e1>", "mRNA", "levels", "in", "the", "C0403396#ent", "<e2>", "and", "nonresponsive", "T-47D", "and", "MDA-MB-231", "cell", "lines", "respectively", "."], "h": {"id": "C1420433", "name": "C1420433#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0403396", "name": "C0403396#ent", "pos": [19, 20]}}
{"token": ["C1417556#ent", "<e1>", "contains", "three", "IQ", "motifs", "that", "bind", "calmodulin", "and", "calmodulin-like", "protein", "C1413769#ent", "<e2>", ")", "as", "light", "chains"], "h": {"id": "C1417556", "name": "C1417556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413769", "name": "C1413769#ent", "pos": [12, 13]}}
{"token": ["C0017237#ent", "<e1>", "is", "investigated", "using", "rheology", "and", "NMR", "C1416400#ent", "<e2>", "relaxation", "measurements", "and", "nuclear", "Overhauser", "enhancement", "spectroscopy", "(", "NOESY", ")", "."], "h": {"id": "C0017237", "name": "C0017237#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416400", "name": "C1416400#ent", "pos": [8, 9]}}
{"token": ["The", "interaction", "of", "native", "and", "Co(II)-substituted", "isozymes", "I", "and", "II", "of", "C0007028#ent", "<e1>", "CA", ")", "with", "histamine", ",", "a", "well-known", "C1422492#ent", "<e2>", ",", "was", "investigated", "kinetically", ",", "spectroscopically", ",", "and", "X-ray", "crystallographically"], "h": {"id": "C0007028", "name": "C0007028#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [20, 21]}}
{"token": ["C1366894#ent", "<e1>", "FAK", ")", "is", "a", "substrate", "of", "both", "caspase-3", "and", "C1705064#ent", "<e2>", ",", "and", "inactivation", "of", "FAK", "by", "these", "caspases", "promotes", "apoptosis", "."], "h": {"id": "C1366894", "name": "C1366894#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705064", "name": "C1705064#ent", "pos": [11, 12]}}
{"token": ["Calmodulin-dependent", "protein", "kinase", "II", "but", "not", "C1956039#ent", "<e1>", "was", "also", "able", "to", "phosphorylate", "the", "C1336767#ent", "<e2>", "."], "h": {"id": "C1956039", "name": "C1956039#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336767", "name": "C1336767#ent", "pos": [14, 15]}}
{"token": ["C0534519#ent", "<e1>", "expression", "was", "little", "detected", "in", "hepatocytes", ",", "and", "C0907533#ent", "<e2>", "and", "IFN-gamma-induced", "mRNA", "expression", "of", "Fas", "or", "caspase-3", "did", "not", "change", "in", "between", "wild", "type", "IRF-1-deficient", "hepatocytes", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}}
{"token": ["The", "hypotensive", "effect", "of", "C0066141#ent", "<e1>", "was", "unaltered", "by", "C0021246#ent", "<e2>", "pretreatment", ",", "ruling", "out", "an", "alteration", "in", "arachidonic", "acid", "metabolism", "as", "the", "mechanism", "of", "action", "."], "h": {"id": "C0066141", "name": "C0066141#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [9, 10]}}
{"token": ["There", "is", "weak", "evidence", "for", "linkage", "of", "C1337034#ent", "<e1>", "to", "a", "C0597336#ent", "<e2>", "influencing", "raised", "mole", "count", "and", "also", "weak", "association", "."], "h": {"id": "C1337034", "name": "C1337034#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0597336", "name": "C0597336#ent", "pos": [11, 12]}}
{"token": ["With", "the", "aim", "of", "morphologically", "characterizing", "C0154304#ent", "<e1>", "patients", "with", "hepatitis", "C", "virus", "HCV", ")", "chronic", "liver", "disease", "labial", "salivary", "gland", "biopsies", "22", "chronic", "C0023895#ent", "<e2>", "from", "10", "primary", "Sj\u00f6gren's", "syndrome", "patients", "were", "compared", "."], "h": {"id": "C0154304", "name": "C0154304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [24, 25]}}
{"token": ["Scapuloperoneal", "(", "SP", ")", "syndrome", "encompasses", "heterogeneous", "C0027868#ent", "<e1>", "characterized", "by", "C0427055#ent", "<e2>", "in", "the", "shoulder-girdle", "and", "peroneal", "muscles"], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [11, 12]}}
{"token": ["This", "study", "confirms", "that", "C0029456#ent", "<e1>", "not", "only", "a", "decreased", "C0005940#ent", "<e2>"], "h": {"id": "C0029456", "name": "C0029456#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [10, 11]}}
{"token": ["12(S)-Hydroxyeicosatetraenoic", "acid", "12(S)HETE", ")", ",", "a", "C1412356#ent", "<e1>", "arachidonic", "acid", "is", "required", "for", "epidermal", "growth", "factor", "DNA", "synthesis", "C1706383#ent", "<e2>", "lens", "epithelial", "cells"], "h": {"id": "C1412356", "name": "C1412356#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [18, 19]}}
{"token": ["In", "10", "patients", "with", "C0085605#ent", "<e1>", "no", "clinical", "evidence", "hepatic", "encephalopathy", "latencies", "of", "peak", "N3", "C1427831#ent", "<e2>", "were", "delayed", "and", "N1-N3", "interpeak", "latencies", "were", "prolonged", "."], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1427831", "name": "C1427831#ent", "pos": [15, 16]}}
{"token": ["This", "review", "considers", "the", "role", "of", "individual", "C1709402#ent", "<e1>", "(", "e.g.", "the", "p85/p110", "heterodimer", ",", "C2713509#ent", "<e2>", "and", "PI3KC2alpha", ")", "as", "well", "their", "downstream", "effector", "targets", "in", "mediating", "chemokine-stimulated", "cell", "migration", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [15, 16]}}
{"token": ["C1709402#ent", "<e1>", "also", "known", "as", "C2713509#ent", "<e2>", ")", "allows", "fast-acting", ",", "heterotrimeric", "GTP-binding", "protein-coupled", "receptors", "access", "this", "pathway", "."], "h": {"id": "C1709402", "name": "C1709402#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [5, 6]}}
{"token": ["Further", "work", "is", "required", "to", "determine", "the", "therapeutic", "value", "C0012403#ent", "<e1>", "combination", "with", "other", "agents", ",", "such", "as", "C0357659#ent", "<e2>", ",", "corticosteroids", ",", "ascorbic", "acid", "citric", "acid", "in", "corneal", "alkali", "injury"], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0357659", "name": "C0357659#ent", "pos": [18, 19]}}
{"token": ["C0238460#ent", "<e1>", "defined", "as", "C0040156#ent", "<e2>", "resulting", "from", "exogenous", "ingestion", "of", "thyroid", "hormone", "usually", "in", "patients", "with", "a", "psychiatric", "disorder"], "h": {"id": "C0238460", "name": "C0238460#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040156", "name": "C0040156#ent", "pos": [4, 5]}}
{"token": ["Recent", "analysis", "of", "the", "Arabidopsis", "proteome", "after", "challenge", "by", "three", "strains", "of", "Pseudomonas", "syringae", "C0086376#ent", "<e1>", "implicated", "in", "the", "establishment", "of", "disease", ",", "C1418551#ent", "<e2>", "and", "ETI", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418551", "name": "C1418551#ent", "pos": [23, 24]}}
{"token": ["C0538030#ent", "<e1>", "induced", "secretion", "of", "HGF", "(", "C1442521#ent", "<e2>", "and", "VEGF", "(", "vascular", "endothelial", "growth", "factor", "from", "cultured", "normal", "human", "dermal", "fibroblasts", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0538030", "name": "C0538030#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [7, 8]}}
{"token": ["From", "these", "results", "and", "from", "elution", "behavior", "of", "these", "proteins", "on", "RPLC", ",", "it", "was", "concluded", "that", "gp60", "and", "C0069919#ent", "<e1>", "are", "the", "BLV", "env", "surface", "glycoprotein", "and", "C0021699#ent", "<e2>", "respectively", "."], "h": {"id": "C0069919", "name": "C0069919#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [28, 29]}}
{"token": ["To", "investigate", "the", "effects", "of", "C1332010#ent", "<e1>", "on", "the", "content", "of", "C0132555#ent", "<e2>", "the", "expression", "of", "endothelium", "nitric", "oxide", "synthase", "artery", "vessels", "experimental", "atherosclerotic", "rats", "."], "h": {"id": "C1332010", "name": "C1332010#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [11, 12]}}
{"token": ["There", "is", "evidence", "for", "improved", "outcome", "with", "total", "parenteral", "nutrition", "premature", "infants", "C0035220#ent", "<e1>", "children", "with", "intractable", "diarrhea", "patients", "with", "C0036992#ent", "<e2>", "acute", "renal", "failure"], "h": {"id": "C0035220", "name": "C0035220#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036992", "name": "C0036992#ent", "pos": [20, 21]}}
{"token": ["Our", "studies", "on", "Neurospora", "crassa", "mitochondria", "have", "included", "sequence", "analysis", "tRNAs", ",", "mapping", "and", "cloning", "of", "the", "tRNA", ",", "rRNA", ",", "and", "C0812324#ent", "<e1>", "the", "DNA", "sequence", "analysis", "these", "C0017337#ent", "<e2>", "."], "h": {"id": "C0812324", "name": "C0812324#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [29, 30]}}
{"token": ["The", "C1417754#ent", "<e1>", "Pes1", "interacts", "with", "Bop1", "and", "C1422404#ent", "<e2>", "in", "a", "stable", "complex", "PeBoW-complex", ")", "and", "its", "expression", "is", "tightly", "associated", "with", "cell", "proliferation"], "h": {"id": "C1417754", "name": "C1417754#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1422404", "name": "C1422404#ent", "pos": [8, 9]}}
{"token": ["Progressive", "C0270612#ent", "<e1>", "reduction", "of", "the", "N-acetyl", "aspartate", "C1445745#ent", "<e2>", "ratio", "were", "evident", "on", "magnetic", "resonance", "spectroscopy", "suggesting", "loss", "of", "myelination", "."], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1445745", "name": "C1445745#ent", "pos": [8, 9]}}
{"token": ["Recent", "advances", "include", "the", "identification", "of", "the", "structural", "genes", "a", "second", "C2350501#ent", "<e1>", ",", "and", "the", "isolation", "of", "a", "C0079429#ent", "<e2>", "responsible", "for", "enhanced", "emulsification", "activity", "a", "high", "molecular", "weight", "biopolymer", "."], "h": {"id": "C2350501", "name": "C2350501#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}}
{"token": ["Our", "data", "indicate", "that", "activation", "of", "C3814146#ent", "<e1>", "or", "MEKK2", "is", "sufficient", "to", "stimulate", "C1334481#ent", "<e2>", ",", "whereas", "inhibition", "of", "either", "C3814146#ent", "<e1>", "or", "MEKK2", "attenuates", "BDNF", "activation", "of", "C1334481#ent", "<e2>", "."], "h": {"id": "C1334481", "name": "C1334481#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3814146", "name": "C3814146#ent", "pos": [6, 7]}}
{"token": ["Porcine", "pancreatic", "elastase", "PPE", ")", "resembles", "the", "attractive", "drug", "target", "C1414369#ent", "<e1>", "which", "has", "been", "implicated", "in", "a", "number", "of", "C0029877#ent", "<e2>"], "h": {"id": "C1414369", "name": "C1414369#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [20, 21]}}
{"token": ["There", "is", "a", "marked", "degree", "of", "specificity", "in", "the", "C0039082#ent", "<e1>", "since", "undiminished", "pressor", "responses", "to", "adrenalin", ",", "C0026454#ent", "<e2>", ",", "methyl", "isothiourea", "observed", "during", "complete", "angiotonin", "refractoriness", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026454", "name": "C0026454#ent", "pos": [18, 19]}}
{"token": ["C0023003#ent", "<e1>", "interaction", "with", "a", "75-kD", "protein", "(", "C1335268#ent", "<e2>", ")", "required", "an", "N-terminal", "portion", "of", "C0023003#ent", "<e1>", "that", "is", "smaller", "than", "the", "region", "required", "for", "the", "overdose", "effect"], "h": {"id": "C0023003", "name": "C0023003#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335268", "name": "C1335268#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "in", "female", "livers", "the", "expression", "of", "C1412499#ent", "<e1>", "was", "mostly", "confined", "to", "perivascular", "C0669372#ent", "<e2>", ",", "whereas", "males", "showed", "a", "more", "homogeneous", "hepatocyte", "staining", "."], "h": {"id": "C1412499", "name": "C1412499#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [15, 16]}}
{"token": ["Aquaporin", "subtypes", "7", "and", "9", "(", "AQP7", "and", "C1412499#ent", "<e1>", ")", "are", "the", "glycerol", "channels", "in", "adipocytes", "and", "C0669372#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C1412499", "name": "C1412499#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}}
{"token": ["Partial", "digestion", "the", "hybrid", "protein", "Staphylococcus", "aureus", "V-8", "protease", "several", "immunoreactive", "C0030956#ent", "<e1>", "that", "appeared", "identical", "to", "fragments", "generated", "from", "authentic", "C0054450#ent", "<e2>"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0054450", "name": "C0054450#ent", "pos": [21, 22]}}
{"token": ["Our", "studies", "demonstrate", "an", "C0919509#ent", "<e1>", "oncogenic", "role", "and", "suggest", "a", "tumorigenic", "mechanism", "in", "which", "C1865737#ent", "<e2>", "activation", "results", "from", "ZNF198", "zinc-finger-mediated", "homodimerization", "."], "h": {"id": "C0919509", "name": "C0919509#ent", "pos": [4, 5]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1865737", "name": "C1865737#ent", "pos": [15, 16]}}
{"token": ["The", "Ash-interacting", "proteins", "stimulated", "the", "GDP/GTP", "exchange", "reaction", "C1537502#ent", "<e1>", "and", "Ha-Ras", "but", "not", "that", "of", "other", "small", "C0752092#ent", "<e2>", "at", "least", "Rap1", ",", "RhoA", ",", "Rac1", ",", "and", "Rab3A", "."], "h": {"id": "C1537502", "name": "C1537502#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752092", "name": "C0752092#ent", "pos": [18, 19]}}
{"token": ["Patients", "exhibiting", "C0030312#ent", "<e1>", "showed", "the", "highest", "C0812443#ent", "<e2>", "concentrations", "."], "h": {"id": "C0030312", "name": "C0030312#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [7, 8]}}
{"token": ["Both", "endosulfan", "and", "C0065601#ent", "<e1>", "promoted", "the", "C0003286#ent", "<e2>", "action", "of", "picrotoxin", "indicating", "that", "the", "insecticides", "were", "able", "to", "show", "proconvulsant", "action", "following", "chronic", "administration"], "h": {"id": "C0065601", "name": "C0065601#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [7, 8]}}
{"token": ["C0007959#ent", "<e1>", "CMT1A", ")", "neuropathy", "is", "caused", "by", "duplication", "of", "the", "C1418677#ent", "<e2>", "PMP22", ")", "gene", ",", "leading", "to", "protein", "overexpression"], "h": {"id": "C0007959", "name": "C0007959#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418677", "name": "C1418677#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "case", "of", "C0007959#ent", "<e1>", "CMT", ")", ",", "with", "identified", "C1418677#ent", "<e2>", "CMT", "type", "1A", ")", ",", "and", "with", "evidence", "of", "an", "inflammatory", "demyelinating", "superimposed", "on", "the", "course", "of", "the", "chronic", "genetic", "disease"], "h": {"id": "C0007959", "name": "C0007959#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418677", "name": "C1418677#ent", "pos": [12, 13]}}
{"token": ["This", "apoptotic", "death", "delayed", "by", "reducing", "C0991617#ent", "<e1>", "and", "by", "a", "C1516312#ent", "<e2>", "but", "it", "is", "prevented", "only", "by", "the", "restoration", "of", "G6PD", "activity", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516312", "name": "C1516312#ent", "pos": [11, 12]}}
{"token": ["C0149514#ent", "<e1>", "a", "self-limited", "respiratory", "disorder", ",", "and", "when", "the", "C0010200#ent", "<e2>", "persists", "for", ">", "3", "weeks", ",", "other", "diagnoses", "must", "be", "considered", "."], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [10, 11]}}
{"token": ["We", "found", "that", "unlike", "codeine", "Bakumondo-to", "had", "a", "notable", "antitussive", "activity", "the", "C0010200#ent", "<e1>", "associated", "with", "C0149514#ent", "<e2>", "and", "the", "C0010200#ent", "<e1>", "increased", "by", "angiotensin-converting", "enzyme", "inhibitors"], "h": {"id": "C0149514", "name": "C0149514#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [12, 13]}}
{"token": ["Lactate", "dehydrogenase", "pyruvate", "kinase", "beta-glucosidase", ",", "C1-fructose", "1.6-diphosphatase", "and", "glucose", "6-phosphatase", "C2932888#ent", "<e1>", "were", "increased", "and", "C1415053#ent", "<e2>", ",", "N-acetyl-beta-D-glucosaminidase", ",", "acid", "phosphatase", "glucose", "6-phosphate", "dehydrogenase", "EC", "1.1.1.49", "showed", "no", "change.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C2932888", "name": "C2932888#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415053", "name": "C1415053#ent", "pos": [16, 17]}}
{"token": ["SR48968", "reduced", "the", "effects", "of", "exogenous", "C1420563#ent", "<e1>", "but", "not", "those", "of", "exogenous", "substance", "P", "C1704949#ent", "<e2>", ",", "indicating", "selective", "blockade", "of", "neurokinin-2", "receptors"], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [15, 16]}}
{"token": ["The", "peripheral-type", "benzodiazepine", "receptor", "C4049614#ent", "<e1>", ")", "has", "been", "autoradiographically", "localized", "to", "the", "thick", "ascending", "C0030196#ent", "<e2>", "and", "early", "distal", "tubule"], "h": {"id": "C4049614", "name": "C4049614#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [15, 16]}}
{"token": ["C0000979#ent", "<e1>", "was", "the", "main", "product", "when", "operating", "at", "an", "C1414662#ent", "<e2>", "of", "10", "gCOD.L(-1).day(-1", ")", "and", "HRT", "of", "6.5", "hours", "in", "both", "reactors", "."], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414662", "name": "C1414662#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "a", "patient", "with", "C0011849#ent", "<e1>", "who", "developed", "a", "C0009492#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009492", "name": "C0009492#ent", "pos": [10, 11]}}
{"token": ["Our", "study", "therefore", "supports", "the", "\"", "weak", "vein", "wall", "theory", "concerning", "the", "etiology", "of", "C0042345#ent", "<e1>", "and", "confirms", "that", "surgery", "for", "C0042345#ent", "<e1>", "the", "C0023222#ent", "<e1>", "concentrate", "on", "removal", "of", "the", "varices", "themselves", "."], "h": {"id": "C0042345", "name": "C0042345#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0023222", "name": "C0023222#ent", "pos": [24, 25]}}
{"token": ["A", "48-year-old", "male", "patient", "had", "two", "episodes", "of", "fever", ",", "headache", ",", "confusion", "and", "C0036572#ent", "<e1>", "following", "an", "C0041912#ent", "<e2>"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [18, 19]}}
{"token": ["Treatment", "of", "Raji", "cells", "with", "SAL", "down-regulated", "C1332791#ent", "<e1>", "GM-CSF", ")", "signaling", "molecule", "Magmas", ")", "gene", ",", "and", "up-regulated", "C0812287#ent", "<e2>", "downstream", "regulated", "gene", "(", "NDRG", ")", "3", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812287", "name": "C0812287#ent", "pos": [19, 20]}}
{"token": ["Similar", "effects", "were", "seen", "when", "E.", "coli", "lipopolysaccharide", "C2697656#ent", "<e1>", ")", "was", "substituted", "for", "suspensions", "of", "C1706331#ent", "<e2>", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [16, 17]}}
{"token": ["C0010592#ent", "<e1>", "treatment", "significantly", "reduced", "C1413132#ent", "<e2>", "in", "control", "and", "lpr", "hearts", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413132", "name": "C1413132#ent", "pos": [5, 6]}}
{"token": ["A", "patient", "with", "ulcerative", "colitis", "C1527407#ent", "<e1>", "sinus", "tachycardia", "skin", "rashes", "headache", "and", "insomnia", "following", "treatment", "with", "C4082693#ent", "<e2>", "."], "h": {"id": "C1527407", "name": "C1527407#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4082693", "name": "C4082693#ent", "pos": [17, 18]}}
{"token": ["Quetiapine", "and", "the", "C1608551#ent", "<e1>", "also", "effective", "for", "treating", "bipolar", "depression", "while", "C0171023#ent", "<e2>", ",", "quetiapine", "and", "aripiprazole", "are", "effective", "during", "the", "maintenance", "phase"], "h": {"id": "C1608551", "name": "C1608551#ent", "pos": [3, 4]}, "relation": "has_constitutional_part", "t": {"id": "C0171023", "name": "C0171023#ent", "pos": [12, 13]}}
{"token": ["To", "compare", "the", "effects", "of", "C0105750#ent", "<e1>", "and", "poractant", "in", "neonatal", "C0035220#ent", "<e2>", "RDS", ")", "."], "h": {"id": "C0105750", "name": "C0105750#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [11, 12]}}
{"token": ["All", "8", "tested", "C0014544#ent", "<e1>", ",", "namely", "carbamazepine", ",", "clonazepam", ",", "diazepam", ",", "C0237417#ent", "<e2>", ",", "ethosuximide", ",", "flunarizine", ",", "phenobarbital", "and", "sodium", "valproate", "decreased", "this", "behaviour", "in", "a", "dose-dependent", "way", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0237417", "name": "C0237417#ent", "pos": [13, 14]}}
{"token": ["The", "activities", "of", "alkaline", "and", "acid", "phosphatase", "nonspecific", "C0014894#ent", "<e1>", ",", "acetylcholinesterase", "and", "C0024544#ent", "<e2>", "of", "lactic", "acid", "investigated", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [13, 14]}}
{"token": ["To", "confirm", "the", "safety", "and", "efficacy", "of", "75", "IU", "lutropin", "alfa", "concomitant", "C1268876#ent", "<e1>", "inducing", "follicular", "development", "in", "women", "with", "profound", "C0162809#ent", "<e2>"], "h": {"id": "C1268876", "name": "C1268876#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0162809", "name": "C0162809#ent", "pos": [21, 22]}}
{"token": ["To", "report", "two", "cases", "of", "C0011860#ent", "<e1>", "after", "the", "initiation", "of", "C0171023#ent", "<e2>", "treatment", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0171023", "name": "C0171023#ent", "pos": [11, 12]}}
{"token": ["The", "C0256371#ent", "<e1>", "displacement", "cross-correlation", "maps", "confirm", "that", "the", "asymmetric", "behaviour", "the", "two", "C0599220#ent", "<e2>", "increases", "as", "a", "function", "of", "temperature", "."], "h": {"id": "C0256371", "name": "C0256371#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [13, 14]}}
{"token": ["Although", "these", "trends", "will", "require", "larger", "patient", "populations", "for", "verification", ",", "these", "data", "suggest", "that", "the", "prognostic", "significance", "C1705982#ent", "<e1>", "mutations", "may", "depend", "on", "the", "amino", "acid", "substitution", "in", "the", "C0080058#ent", "<e2>"], "h": {"id": "C1705982", "name": "C1705982#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [30, 31]}}
{"token": ["Our", "results", "demonstrate", "that", "activation", "of", "both", "Nod1", "and", "C1826449#ent", "<e1>", "results", "in", "substantial", "secretion", "of", "C1332691#ent", "<e2>", "by", "murine", "macrophages", "."], "h": {"id": "C1826449", "name": "C1826449#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [16, 17]}}
{"token": ["Adding", "C0379142#ent", "<e1>", "to", "the", "renal", "pelvic", "containing", "C3273406#ent", "<e2>", "restored", "the", "increases", "in", "ARNA", "and", "the", "PGE(2)-mediated", "substance", "P", "release", "toward", "control", "(", "27+/-6", "%", "and", "7+/-1", "pg/min", ")", "."], "h": {"id": "C0379142", "name": "C0379142#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [8, 9]}}
{"token": ["SHPS-1", "is", "a", "C0021699#ent", "<e1>", "binds", "the", "C0214604#ent", "<e2>", "SHP-2", "through", "its", "cytoplasmic", "region", "is", "abundantly", "expressed", "on", "dendritic", "cells", "macrophages", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0214604", "name": "C0214604#ent", "pos": [7, 8]}}
{"token": ["SHPS-1", "is", "a", "C0021699#ent", "<e1>", "binds", "the", "C0214604#ent", "<e2>", "SHP-2", "and", "is", "abundant", "on", "the", "surface", "of", "CD11c(+", ")", "dendritic", "cells", "DCs", ")", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0214604", "name": "C0214604#ent", "pos": [7, 8]}}
{"token": ["Several", "known", "and", "unknown", "partners", "of", "AR", ",", "including", "C0919496#ent", "<e1>", ",", "Pax", "3/5", "(", "BSAP", ")", ",", "C1704703#ent", "<e2>", ",", "RREB-1", ",", "LIII", "BP", ",", "and", "NPAS2", "were", "identified", "."], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704703", "name": "C1704703#ent", "pos": [18, 19]}}
{"token": ["Hippocampal", "mRNAs", "for", "NGF", "and", "C1706578#ent", "<e1>", "increased", "and", "decreased", ",", "respectively", ",", "in", "C0022471#ent", "<e2>", "acid-treated", "rats", "."], "h": {"id": "C1706578", "name": "C1706578#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [14, 15]}}
{"token": ["The", "causes", "of", "C0033771#ent", "<e1>", "subacuta", "include", "metabolic", "and", "C0014130#ent", "<e2>", "well", "as", "skin", "diseases"], "h": {"id": "C0033771", "name": "C0033771#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [9, 10]}}
{"token": ["In", "pulmonary", "tuberculosis", "the", "proportion", "of", "lymphocytes", ",", "particularly", "that", "of", "C0206744#ent", "<e1>", "was", "increased", "in", "bronchoalveolar", "lavage", "fluid", "C1704942#ent", "<e2>", ")", ",", "reflecting", "their", "protective", "role", "against", "mycobacterial", "infections"], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [19, 20]}}
{"token": ["Sex", "hormone", "regulator", "C1415739#ent", "<e1>", "identified", "under", "C1705526#ent", "<e2>", "introduction", ",", "which", "induced", "the", "5-LOX", "expression", "."], "h": {"id": "C1415739", "name": "C1415739#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [7, 8]}}
{"token": ["Usher", "syndrome", "a", "heterogeneous", "group", "autosomal", "recessive", "disorders", "combines", "variably", "severe", "congenital", "neurosensory", "hearing", "impairment", "progressive", "C0028077#ent", "<e1>", "and", "visual", "loss", "similar", "to", "that", "in", "C0220701#ent", "<e2>"], "h": {"id": "C0028077", "name": "C0028077#ent", "pos": [16, 17]}, "relation": "manifestation_of", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [25, 26]}}
{"token": ["Whether", "the", "prevalence", "of", "coronary", "artery", "disease", "C3813548#ent", "<e1>", ")", "is", "associated", "with", "polymorphism", "in", "exon", "B", "C1418779#ent", "<e2>", "was", "investigated", "in", "Korean", "adults"], "h": {"id": "C3813548", "name": "C3813548#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [17, 18]}}
{"token": ["Oviduct", "samples", "female", "rabbits", "in", "different", "phases", "of", "the", "reproductive", "cycle", "analysed", "to", "establish", "the", "role", "of", "C0038317#ent", "<e1>", "hormones", "in", "the", "regulation", "of", "sulphatide", "concentration", "and", "C0003940#ent", "<e2>", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003940", "name": "C0003940#ent", "pos": [27, 28]}}
{"token": ["Expression", "of", "gtmG", "together", "with", "gtmB-gtmA-gacH", "led", "to", "production", "of", "2'-N-acetylparomamine", ",", "demonstrating", "that", "GtmG", "acts", "as", "a", "C0085249#ent", "<e1>", "that", "adds", "C0001056#ent", "<e2>", "(", "GLcNA", ")", "to", "2-DOS", "."], "h": {"id": "C0085249", "name": "C0085249#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0001056", "name": "C0001056#ent", "pos": [22, 23]}}
{"token": ["All", "four", "C0085249#ent", "<e1>", "were", "inhibited", ",", "the", "C0001056#ent", "<e2>", "and", "N-acetylgalactosaminyltransferases", "by", "more", "than", "95", "%", "."], "h": {"id": "C0085249", "name": "C0085249#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001056", "name": "C0001056#ent", "pos": [8, 9]}}
{"token": ["Our", "data", "suggest", "that", "C1430988#ent", "<e1>", "phosphorylation", "and", "activation", "of", "C1705984#ent", "<e2>", ",", "CD40", "and", "RANK", "may", "play", "a", "role", "in", "activating", "Akt", "in", "HRS", "cells", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705984", "name": "C1705984#ent", "pos": [10, 11]}}
{"token": ["This", "is", "a", "case", "history", "a", "patient", "with", "C0574084#ent", "<e1>", "the", "characteristics", "of", "this", "C1848862#ent", "<e2>", "and", "the", "gene", "that", "causes", "this", "disease", "."], "h": {"id": "C0574084", "name": "C0574084#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [14, 15]}}
{"token": ["Local", "intramyocardial", "delivery", "(", "C0051149#ent", "<e1>", ")", "is", "under", "active", "clinical", "investigation", "for", "cell", "therapies", "treat", "C0018802#ent", "<e2>", "and", "gene", "therapies", "induce", "revascularization", "of", "ischemic", "myocardium", "coronary", "artery", "disease"], "h": {"id": "C0051149", "name": "C0051149#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [16, 17]}}
{"token": ["In", "these", "patients", ",", "however", ",", "we", "believed", "to", "having", "C1704945#ent", "<e1>", "because", "of", "the", "C1997362#ent", "<e2>", "findings", "of", "EMG", "in", "the", "thoracic", "paraspinal", "muscles"], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1997362", "name": "C1997362#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "inhibition", "of", "tumor", "cell", "lines", "growth", "and", "the", "demethylation", "of", "C1705280#ent", "<e1>", "a", "component", "of", "C0013227#ent", "<e2>", "CDP", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [18, 19]}}
{"token": ["The", "mechanism", "of", "increased", "cathelicidin", "in", "psoriatic", "keratinocytes", "not", "known", ",", "but", "recent", "observations", "have", "found", "that", "C0033860#ent", "<e1>", "has", "abundant", "Th17", "cells", "produce", "C1825592#ent", "<e2>", "and", "IL-22", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [17, 18]}, "relation": "disease_has_associated_gene", "t": {"id": "C1825592", "name": "C1825592#ent", "pos": [24, 25]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "determine", "the", "prevalence", "of", "C0021832#ent", "<e1>", "children", "with", "C0426576#ent", "<e2>", "and", "to", "evaluate", "its", "association", "with", "socio-economic", "and", "environmental", "factors"], "h": {"id": "C0021832", "name": "C0021832#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [15, 16]}}
{"token": ["Giardia", "lamblia", "the", "most", "common", "C0021832#ent", "<e1>", "the", "United", "States", "may", "present", "with", "nonspecific", "C0426576#ent", "<e2>", "the", "infection", "is", "chronic", "."], "h": {"id": "C0021832", "name": "C0021832#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [14, 15]}}
{"token": ["Thrombolytic", "therapy", "C0032143#ent", "<e1>", "rt-PA", ")", "resulted", "in", "rapid", "resolution", "of", "C0019151#ent", "<e2>", "ascites", "with", "improvement", "in", "liver", "function"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [11, 12]}}
{"token": ["We", "suggest", "that", "F2L", "will", "potentially", "be", "useful", "in", "the", "study", "of", "C1414691#ent", "<e1>", "signaling", "and", "the", "development", "of", "drugs", "to", "treat", "C0012634#ent", "<e2>", "involving", "the", "C1414691#ent", "<e1>", "in", "the", "vascular", "system"], "h": {"id": "C1414691", "name": "C1414691#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}}
{"token": ["WUS", "transcripts", "accumulated", ">", "238-fold", "in", "C1332381#ent", "<e1>", "-", "3", "compared", "with", "the", "C1883559#ent", "<e2>", "were", "located", "mainly", "in", "the", "outermost", "cell", "layers", "of", "the", "usual", "organizing", "center"], "h": {"id": "C1332381", "name": "C1332381#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [13, 14]}}
{"token": ["In", "our", "present", "results", ",", "ischemic", "preconditioning", "could", "not", "only", "inhibit", "activations", "of", "C0534507#ent", "<e1>", "JNK1/2", ",", "and", "c-Jun", "but", "also", "enhanced", "activation", "of", "C0285558#ent", "<e2>", "."], "h": {"id": "C0534507", "name": "C0534507#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [24, 25]}}
{"token": ["C1955934#ent", "<e1>", "(", "TTD", ")", "patients", "with", "a", "mutation", "in", "the", "C1333356#ent", "<e2>", "nucleotide", "excision", "repair", "NER", ")", "have", "a", "short", "life", "span", "and", "show", "various", "features", "of", "premature", "aging", "thereby", "linking", "DNA", "damage", "the", "aging", "process"], "h": {"id": "C1955934", "name": "C1955934#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1333356", "name": "C1333356#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "indicate", "a", "diffuse", "tapetoretinal", "degeneration", "and", "suggest", "that", "pigmented", "C4072868#ent", "<e1>", "another", "incomplete", "form", "of", "C0220701#ent", "<e2>"], "h": {"id": "C4072868", "name": "C4072868#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [17, 18]}}
{"token": ["This", "inhibition", "was", "antagonized", "by", "idazoxan", ",", "an", "C0304513#ent", "<e1>", "but", "not", "by", "R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzaz", "epine", "hydrochloride", "(", "C0080138#ent", "<e2>", ")", ",", "a", "dopamine", "D1", "receptor", "antagonist"], "h": {"id": "C0304513", "name": "C0304513#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0080138", "name": "C0080138#ent", "pos": [17, 18]}}
{"token": ["Immobilized", "Concanavalin", "A-Sepharose", "4B", "(", "CSB", ")", "binds", "C0067034#ent", "<e1>", "IgG", "through", "C1415975#ent", "<e2>", ")", "in", "larger", "proportions", "than", "it", "binds", "normal", "immunoglobulins", "."], "h": {"id": "C0067034", "name": "C0067034#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [12, 13]}}
{"token": ["Further", "investigation", ",", "blood", "collection", "educating", "the", "farmer", ",", "and", "prescribed", "affected", "herd", "with", "C0724713#ent", "<e1>", "were", "performed", "soon", "after", "C0040558#ent", "<e2>", "demonstrated", "."], "h": {"id": "C0724713", "name": "C0724713#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0040558", "name": "C0040558#ent", "pos": [20, 21]}}
{"token": ["Results", "showed", "that", "all", "of", "the", "CCA", "'s", "except", "verapamil", "produced", "significant", "C1825840#ent", "<e1>", "at", "the", "30-min", "interval", "and", "nimodipine", "and", "C0282138#ent", "<e2>", "also", "significantly", "increased", "C1825840#ent", "<e1>", "at", "the", "60-min-delay", "interval", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [21, 22]}}
{"token": ["In", "T", "cells", "Saccharomyces", "cerevisiae", "C0010592#ent", "<e1>", "and", "FK506", "bind", "to", "the", "immunophilins", "cyclophilin", "A", "C1414618#ent", "<e2>", "and", "the", "resulting", "complexes", "inhibit", "the", "Ca2", "+", "-regulated", "protein", "phosphatase", "calcineurin"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414618", "name": "C1414618#ent", "pos": [15, 16]}}
{"token": ["The", "principal", "C0010592#ent", "<e1>", "A", "and", "tacrolimus", "binding", "proteins", "cyclophilin", "A", "C1414618#ent", "<e2>", "were", "also", "expressed", "by", "keratinocytes", "and", "nonimmune", "cells", "in", "skin", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414618", "name": "C1414618#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", "we", "demonstrate", "that", "C1706474#ent", "<e1>", "efficiently", "inhibited", "virus-induced", "expression", "of", "endogenous", "interferon", "B", "C1332679#ent", "<e2>", "RANTES", "and", "CXC", "chemokine", "IP-10", "genes"], "h": {"id": "C1706474", "name": "C1706474#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332679", "name": "C1332679#ent", "pos": [16, 17]}}
{"token": ["The", "selectivity", "factors", "KIB/KIA", "of", "various", "C1413167#ent", "<e1>", "related", "peptides", "vary", "from", "58", "for", "C1705157#ent", "<e2>", "to", "26", "for", "CCK8", "and", "4", "for", "the", "antagonist", "(", "Nle28,31", ")", "CCK27", "-", "32-NH2", "."], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705157", "name": "C1705157#ent", "pos": [14, 15]}}
{"token": ["Using", "polymerase", "chain", "reaction-RFLP", "analyses", "of", "the", "gene", "from", "the", "three", "C1868117#ent", "<e1>", ",", "we", "found", "that", "the", "exon", "1", "exon", "8", "and", "exon", "9", "C1828472#ent", "<e2>", "were", "absent", "."], "h": {"id": "C1868117", "name": "C1868117#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1828472", "name": "C1828472#ent", "pos": [25, 26]}}
{"token": ["C0935942#ent", "<e1>", "is", "effective", "against", "both", "invasive", "C0004030#ent", "<e2>", "and", "invasive", "candidiasis"], "h": {"id": "C0935942", "name": "C0935942#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004030", "name": "C0004030#ent", "pos": [7, 8]}}
{"token": ["Based", "on", "experiences", "with", "other", "C0040615#ent", "<e1>", "the", "safety", "profile", "of", "C0062103#ent", "<e2>", "unlikely", "to", "differ", "from", "short-acting", "formulations", "of", "haloperidol", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [5, 6]}, "relation": "therapeutic_class_of", "t": {"id": "C0062103", "name": "C0062103#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "carried", "out", "to", "determine", "the", "role", "of", "MT", "in", "Cu", "depletion", "by", "a", "Cu(I)-specific", "chelator", ",", "C0053000#ent", "<e1>", "BCS", ")", ",", "in", "cultured", "cells", "from", "MT-knockout", "mouse", "its", "C1883559#ent", "<e2>"], "h": {"id": "C0053000", "name": "C0053000#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [31, 32]}}
{"token": ["C0008932#ent", "<e1>", ",", "flavoxate", ",", "and", "C0042523#ent", "<e2>", "concentration-dependently", "inhibited", "field", "stimulation-induced", "contraction", "."], "h": {"id": "C0008932", "name": "C0008932#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [6, 7]}}
{"token": ["Pertinent", "information", "concerning", "the", "C0001519#ent", "<e1>", "is", "provided", "for", "the", "practicing", "and", "C0004057#ent", "<e2>", "neurologist", ",", "including", "anatomy", "and", "physiology", "of", "the", "normal", "C0001519#ent", "<e1>", ",", "a", "discussion", "of", "pupillary", "disorders", "and", "unusual", "pupillary", "abnormalities"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001519", "name": "C0001519#ent", "pos": [4, 5]}}
{"token": ["In", "the", "present", "study", ",", "we", "investigated", "the", "effects", "of", "parathyroid", "hormone", "PTH", "(", "1", "-", "34", ")", "]", "on", "RANKL", "and", "C0671550#ent", "<e1>", "production", "in", "cultured", "normal", "human", "osteoblast-like", "cells", "C0812235#ent", "<e2>", ")", "."], "h": {"id": "C0671550", "name": "C0671550#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0812235", "name": "C0812235#ent", "pos": [31, 32]}}
{"token": ["Both", "C3541394#ent", "<e1>", "show", "a", "predominance", "of", "one", "C1706112#ent", "<e2>", ",", "with", "the", "other", "variants", "being", "fairly", "rare", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [8, 9]}}
{"token": ["Southern", "blot", "analysis", "Mu", "elements", "these", "plants", "demonstrates", "a", "correlation", "between", "an", "inhibition", "of", "digestion", "of", "Mu", "elements", "certain", "restriction", "C3541394#ent", "<e1>", "and", "the", "loss", "of", "somatic", "reversion", "at", "the", "mutant", "C1706112#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [31, 32]}}
{"token": ["In", "25/29", "(", "86", "%", ")", "of", "the", "patients", ",", "spontaneous", "remission", "preceded", "by", "C0042769#ent", "<e1>", "among", "which", "C0595993#ent", "<e2>", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0595993", "name": "C0595993#ent", "pos": [18, 19]}}
{"token": ["We", "describe", "a", "49-year-old", "female", "Japanese", "hairdresser", "who", "presented", "with", "a", "5-year", "history", "of", "exertional", "dyspnea", "a", "C0850149#ent", "<e1>", "and", "occasional", "C0015967#ent", "<e2>", "episodes", "."], "h": {"id": "C0850149", "name": "C0850149#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [21, 22]}}
{"token": ["The", "first", "mutant", ",", ".61", ",", "lacks", "expression", "of", "both", "TAP1", "and", "TAP2", "C1417679#ent", "<e1>", ",", "and", "of", "both", "LMP2", "and", "C3811068#ent", "<e2>", "proteasome", "subunits"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3811068", "name": "C3811068#ent", "pos": [21, 22]}}
{"token": ["There", "were", "some", "adaptive", "changes", "in", "the", "levels", "of", "cytosolic", "superoxide", "dismutase", "glutathione", "peroxidase", "and", "catalase", "in", "response", "to", "C1510471#ent", "<e1>", "whereas", "neither", "oxidative", "enzymes", "C1420307#ent", "<e2>", "altered", "."], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420307", "name": "C1420307#ent", "pos": [25, 26]}}
{"token": ["Suramin", "is", "a", "drug", "used", "in", "the", "therapy", "of", "Rhodesian", "trypanosomiasis", "C0029001#ent", "<e1>", ",", "and", "it", "is", "known", "to", "inhibit", "the", "C0035379#ent", "<e2>", "a", "number", "of", "retroviruses", "."], "h": {"id": "C0029001", "name": "C0029001#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035379", "name": "C0035379#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "we", "show", "that", "BAL2", "and", "C1538590#ent", "<e1>", ",", "but", "not", "C1538586#ent", "<e2>", ",", "exhibit", "PARP", "activity", "."], "h": {"id": "C1538590", "name": "C1538590#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538586", "name": "C1538586#ent", "pos": [13, 14]}}
{"token": ["We", "have", "used", "confocal", "microscopy", "elucidate", "the", "effects", "of", "C0002842#ent", "<e1>", "on", "nuclear", "localization", "the", "androgen", "receptor", "AR", ")", "with", "its", "C1425716#ent", "<e2>", "GRIP1", "."], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425716", "name": "C1425716#ent", "pos": [21, 22]}}
{"token": ["C1314817#ent", "<e1>", "Stedicor", ")", "is", "a", "new", "class", "III", "C2979921#ent", "<e2>", "is", "being", "developed", "by", "Proctor", "&", "Gamble", "to", "treat", "supraventricular", "and", "ventricular", "arrhythmias"], "h": {"id": "C1314817", "name": "C1314817#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2979921", "name": "C2979921#ent", "pos": [9, 10]}}
{"token": ["To", "compare", "the", "efficacy", "and", "safety", "of", "anterior", "chamber", "AC", ")", "intraocular", "lenses", "IOLs", ")", "and", "posterior", "chamber", "C1418943#ent", "<e1>", ")", "IOLs", "implanted", "after", "C0271408#ent", "<e2>", "presentation", "during", "extracapsular", "cataract", "extraction", "ECCE", ")", "."], "h": {"id": "C1418943", "name": "C1418943#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0271408", "name": "C0271408#ent", "pos": [24, 25]}}
{"token": ["Five", "patients", "with", "chronic", "bacterial", "infections", "two", "with", "osteomyelitis", ",", "two", "with", "infected", "vascular", "prostheses", "one", "with", "soft", "tissue", "abscess", ",", "but", "without", "C0014118#ent", "<e1>", ",", "developed", "signs", "of", "C0017658#ent", "<e2>", "and", "renal", "failure"], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [29, 30]}}
{"token": ["In", "contrast", ",", "Mg2", "+", "and", "C3811061#ent", "<e1>", "exhibited", "optimal", "concentrations", "for", "stimulation", "and", "both", "inhibited", "the", "C0035541#ent", "<e2>", "at", "concentrations", "above", "these", "optima", "."], "h": {"id": "C3811061", "name": "C3811061#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [17, 18]}}
{"token": ["Cholestanol", "and", "C0037215#ent", "<e1>", "competitively", "inhibited", "C0008396#ent", "<e2>", "both", "rat", "and", "human", "liver", "microsomes", ",", "with", "cholestanol", "the", "more", "potent", "inhibitor", "."], "h": {"id": "C0037215", "name": "C0037215#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008396", "name": "C0008396#ent", "pos": [6, 7]}}
{"token": ["This", "study", "indicates", "that", ",", "relative", "to", "C0003873#ent", "<e1>", "and", "RG", ",", "C1419337#ent", "<e2>", "has", "less", "toxicity", "but", "similar", "immunological", "effects"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419337", "name": "C1419337#ent", "pos": [12, 13]}}
{"token": ["Cdc42", "C1333729#ent", "<e1>", "and", "its", "effectors", ",", "C1955933#ent", "<e2>", "Pak2", "and", "Pak1", ",", "are", "not", "upstream", "elements", "controlling", "the", "basal", "level", "or", "the", "stress-induced", "activation", "Pmk1", "."], "h": {"id": "C1333729", "name": "C1333729#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1955933", "name": "C1955933#ent", "pos": [7, 8]}}
{"token": ["We", "evaluated", "here", "the", "role", "of", "a", "coding", "variation", "Ser249Pro", ",", "in", "the", "TLR6", "gene", "the", "pathogenesis", "of", "asthma", ",", "C0013595#ent", "<e1>", "AD", ")", "and", "chronic", "obstructive", "pulmonary", "disease", "C3714496#ent", "<e2>", ")", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3714496", "name": "C3714496#ent", "pos": [29, 30]}}
{"token": ["C1142110#ent", "<e1>", "a", "potentially", "life-threatening", "cause", "of", "C0003460#ent", "<e2>", "."], "h": {"id": "C1142110", "name": "C1142110#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003460", "name": "C0003460#ent", "pos": [7, 8]}}
{"token": ["Our", "data", "suggest", "that", "C1335621#ent", "<e1>", "is", "a", "good", "candidate", "C1332010#ent", "<e2>", "silenced", "by", "hypermethylation", "in", "cancer", "."], "h": {"id": "C1335621", "name": "C1335621#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332010", "name": "C1332010#ent", "pos": [10, 11]}}
{"token": ["Steroid", "injections", "are", "often", "employed", "as", "an", "alternative", "treatment", "C0278147#ent", "<e1>", "patients", "with", "C1285162#ent", "<e2>"], "h": {"id": "C0278147", "name": "C0278147#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [13, 14]}}
{"token": ["Bound", "C0039667#ent", "<e1>", "could", "be", "released", "from", "the", "protein", "with", "C1705556#ent", "<e2>", "."], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["This", "bound", "C0039667#ent", "<e1>", "could", "be", "rescued", "by", "addition", "of", "C1705556#ent", "<e2>", "and", "KCl", "into", "the", "refolding", "mixture"], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [10, 11]}}
{"token": ["The", "C0169661#ent", "<e1>", "required", "for", "PRL", "activation", "of", "C1414461#ent", "<e2>", "promoter", "activity", "however", ",", "additional", "pathways", "are", "involved", "in", "PRL-induced", "Stat5b", "phosphorylation", ",", "nuclear", "translocation", "DNA", "binding"], "h": {"id": "C0169661", "name": "C0169661#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [8, 9]}}
{"token": ["Several", "further", "manifestations", "are", "associated", "with", "B19", "infections", "such", "as", "arthralgias", ",", "C0029408#ent", "<e1>", ",", "leucopenia", "and", "thrombocytopenia", ",", "C0002871#ent", "<e2>", "and", "vasculitis", "and", "spontaneous", "abortion", "hydrops", "fetalis", "pregnant", "women"], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [19, 20]}}
{"token": ["The", "C4084713#ent", "<e1>", "I-overexpressing", "embryos", "exhibited", "smaller", "C0235267#ent", "<e2>", "and", "enlargement", "of", "the", "forebrain", ",", "a", "phenotype", "similar", "to", "that", "observed", "in", "the", "cAMP-dependent", "protein", "kinase", "embryos", "."], "h": {"id": "C4084713", "name": "C4084713#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [7, 8]}}
{"token": ["This", "region", "contains", "the", "three", "toxin", "genes", "C0010592#ent", "<e1>", ",", "lef", ",", "and", "C1418879#ent", "<e2>", ")", ",", "regulatory", "elements", "the", "toxin", "genes", "three", "germination", "response", "genes", ",", "and", "19", "additional", "ORFs", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418879", "name": "C1418879#ent", "pos": [13, 14]}}
{"token": ["These", "differences", "can", "not", "be", "attributed", "to", "more", "severe", "positive", "C0871189#ent", "<e1>", "a", "greater", "C2926735#ent", "<e2>", "of", "illness", "in", "the", "deficit", "group"], "h": {"id": "C0871189", "name": "C0871189#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [14, 15]}}
{"token": ["Small", "airway", "remodeling", "C4283882#ent", "<e1>", ")", "is", "an", "important", "cause", "of", "airflow", "obstruction", "in", "cigarette", "smokers", "C0024117#ent", "<e2>", "but", "the", "pathogenesis", "of", "C4283882#ent", "<e1>", "is", "not", "understood", "."], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C4283882", "name": "C4283882#ent", "pos": [3, 4]}}
{"token": ["Endothelin-1", "(", "C3273436#ent", "<e1>", ")", "is", "a", "potent", "vasoconstrictor", "peptide", "by", "vascular", "endothelin", "cells", "are", "reports", "in", "the", "literature", "that", "C3273436#ent", "<e1>", "plasma", "levels", "are", "raised", "in", "low", "tension", "glaucoma", "C1420817#ent", "<e1>", ")", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420817", "name": "C1420817#ent", "pos": [30, 31]}}
{"token": ["These", "results", "suggest", "two", "mechanisms", "of", "C1537647#ent", "<e1>", "downregulation", "after", "C1414863#ent", "<e2>", ",", "one", "dependent", "on", "and", "one", "independent", "of", "recurrent", "seizures", "."], "h": {"id": "C1537647", "name": "C1537647#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414863", "name": "C1414863#ent", "pos": [10, 11]}}
{"token": ["The", "amino-", "and", "carboxyl-terminal", "amino", "acid", "sequences", "proteins", "(", "p10", ",", "C0525037#ent", "<e1>", ",", "p15", ",", "and", "p30", ")", "coded", "by", "the", "C0017346#ent", "<e2>", "Rauscher", "and", "AKR", "murine", "leukemia", "viruses", "were", "determined", "."], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [22, 23]}}
{"token": ["A", "double-blind", ",", "randomized", "crossover", "study", "28", "C0004096#ent", "<e1>", "patients", "assessed", "the", "relative", "therapeutic", "index", "C0060657#ent", "<e2>", "salbutamol", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0060657", "name": "C0060657#ent", "pos": [15, 16]}}
{"token": ["However", ",", "partial", "substitution", "was", "observed", "with", "C0018602#ent", "<e1>", ",", "harmane", ",", "harmalol", ",", "and", "C0077436#ent", "<e2>", "(", "THBC", ")", "."], "h": {"id": "C0018602", "name": "C0018602#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0077436", "name": "C0077436#ent", "pos": [15, 16]}}
{"token": ["One", "patient", "with", "C0024588#ent", "<e1>", "the", "features", "of", "C0033141#ent", "<e2>", "necropsy", "."], "h": {"id": "C0024588", "name": "C0024588#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033141", "name": "C0033141#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "C1428560#ent", "<e1>", "and", "Ten1", "show", "similarities", "to", "Rpa2", "and", "Rpa3", ",", "C0599220#ent", "<e2>", "of", "the", "heterotrimeric", "replication", "protein", "A", "RPA", ")", "complex", ",", "which", "is", "the", "major", "single-stranded", "DNA-binding", "activity", "in", "eukaryotic", "cells"], "h": {"id": "C1428560", "name": "C1428560#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [13, 14]}}
{"token": ["When", "compared", "to", "controls", ",", "infection", "with", "the", "139A", "C0036457#ent", "<e1>", "strain", "resulted", "in", "decreased", "activity", "of", "the", "cholinergic", "pathway-related", "C3540772#ent", "<e2>", ",", "choline", "acetyltransferase", "acetylcholinesterase", "."], "h": {"id": "C0036457", "name": "C0036457#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [20, 21]}}
{"token": ["It", "is", "similar", "in", "respect", "to", "morphology", ",", "enzyme", ",", "and", "membrane", "markers", "responsiveness", "to", "vincristine", "and", "C0032950#ent", "<e1>", "therapy", "to", "the", "lymphoid", "blast", "seen", "in", "C2827376#ent", "<e2>", "+", "CGL", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2827376", "name": "C2827376#ent", "pos": [26, 27]}}
{"token": ["These", "observations", "suggest", "that", "the", "C0596110#ent", "<e1>", ",", "natriuretic", "and", "renin", "suppressive", "effects", "of", "C0936073#ent", "<e2>", "be", "due", "to", "an", "inhibition", "of", "intrarenal", "sympathetic", "nervous", "system", "due", "to", "a", "direct", "tubular", "action"], "h": {"id": "C0596110", "name": "C0596110#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [14, 15]}}
{"token": ["Much", "stronger", "transcriptional", "activation", "consistently", "seen", "for", "the", "C1850932#ent", "<e1>", "constructs", "than", "for", "the", "corresponding", "C1428221#ent", "<e2>", "constructs", "."], "h": {"id": "C1850932", "name": "C1850932#ent", "pos": [8, 9]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1428221", "name": "C1428221#ent", "pos": [15, 16]}}
{"token": ["Interfering", "with", "CHIP", "expression", "resulted", "in", "stabilization", "of", "C1706586#ent", "<e1>", "and", "enhanced", "cell", "migration", "as", "observed", "in", "C1337109#ent", "<e2>", "knockdown", "cells"], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1337109", "name": "C1337109#ent", "pos": [17, 18]}}
{"token": ["Finally", ",", "C0164786#ent", "<e1>", "phosphorylation", "was", "diminished", "after", "GPVI", "or", "C1335191#ent", "<e2>", "stimulation", "in", "platelets", "from", "HS1-null", "mice", "compared", "with", "their", "wild-type", "littermates", "."], "h": {"id": "C0164786", "name": "C0164786#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335191", "name": "C1335191#ent", "pos": [10, 11]}}
{"token": ["The", "serum", "concentrations", "of", "the", "basic", "C3541861#ent", "<e1>", "were", "high", "in", "acromegalics", "and", "low", "in", "patients", "with", "C0020635#ent", "<e2>", "."], "h": {"id": "C3541861", "name": "C3541861#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020635", "name": "C0020635#ent", "pos": [17, 18]}}
{"token": ["Heterozygosity", "at", "the", "C1412131#ent", "<e1>", "SRO-2p25", ")", "and", "normal", "levels", "of", "C0024544#ent", "<e2>", "SRO-2p23", ")", "are", "findings", "consistent", "with", "presence", "of", "genetic", "material", "bands", "2p25", "and", "2p23", "."], "h": {"id": "C1412131", "name": "C1412131#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [11, 12]}}
{"token": ["They", "are", "alpha-hydroxynitrile", "glucosides", ",", "which", "release", "toxic", "hydrogen", "cyanide", "C1537647#ent", "<e1>", ")", "upon", "cleavage", "by", "endogenous", "plant", "C0005223#ent", "<e2>", "."], "h": {"id": "C1537647", "name": "C1537647#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [18, 19]}}
{"token": ["To", "evaluate", "this", "further", ",", "genomic", "C0011519#ent", "<e1>", "from", "62", "isolates", "of", "E.", "coli", "O157:H7", "from", "different", "cattle", "C1519228#ent", "<e2>", "were", "digested", "with", "XbaI", "and", "BlnI", "and", "subjected", "to", "PFGE", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1519228", "name": "C1519228#ent", "pos": [18, 19]}}
{"token": ["After", "r-PhyA", "and", "r-AppA", "were", "incubated", "with", "different", "concentrations", "of", "C0030909#ent", "<e1>", "or", "trypsin", ",", "their", "residual", "C0031853#ent", "<e2>", "activities", "and", "amounts", "of", "inorganic", "phosphorus", "released", "from", "soybean", "meal", "determined", "."], "h": {"id": "C0030909", "name": "C0030909#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031853", "name": "C0031853#ent", "pos": [17, 18]}}
{"token": ["Results", "similar", "to", "those", "with", "C0030909#ent", "<e1>", "at", "pH", "3.5", "were", "obtained", "following", "preincubation", "of", "the", "C0031853#ent", "<e2>", "in", "the", "presence", "of", "pancreatin", "at", "pH", "6.0", "."], "h": {"id": "C0030909", "name": "C0030909#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031853", "name": "C0031853#ent", "pos": [16, 17]}}
{"token": ["Electrical", "stimulation", "the", "isolated", "rat", "C0025472#ent", "<e1>", "in", "a", "frequency-dependent", "C0237795#ent", "<e2>", "response", ",", "which", "could", "be", "potentiated", "by", "increasing", "concentrations", "of", "renin", "substrate", "synthetic", "tetradecapeptide", ")", "."], "h": {"id": "C0025472", "name": "C0025472#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [10, 11]}}
{"token": ["Experiments", "with", "peptide", "inhibitors", "cysteine", "and", "C2717971#ent", "<e1>", "that", "caspases", "were", "the", "predominant", "C0127400#ent", "<e2>", "of", "apoptosis", "induced", "by", "TNF-alpha", "alone", "but", "that", "C2717971#ent", "<e1>", "significantly", "to", "cell", "death", "induced", "by", "TNF-alpha", "plus", "irradiation", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "the", "efficacy", "and", "safety", "of", "topical", "rubefacients", "containing", "C0036075#ent", "<e1>", "in", "acute", "and", "C0150055#ent", "<e2>"], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0150055", "name": "C0150055#ent", "pos": [15, 16]}}
{"token": ["Mutations", "identified", "in", "the", "hypoxanthine", "phosphoribosyltransferase", "HPRT", ")", "C0079429#ent", "<e1>", "of", "patients", "with", "C0023374#ent", "<e2>", "(", "LN", ")", "syndrome", "are", "dominated", "by", "simple", "base", "substitutions"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [13, 14]}}
{"token": ["To", "describe", "the", "clinical", "phenotype", "in", "infants", "with", "C1859722#ent", "<e1>", "the", "association", "of", "arthrogryposis", ",", "C0001126#ent", "<e2>", "and", "cholestasis", "."], "h": {"id": "C1859722", "name": "C1859722#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0001126", "name": "C0001126#ent", "pos": [15, 16]}}
{"token": ["However", ",", "C0055729#ent", "<e1>", "does", "cause", "minor", "side", "effects", "headache", ",", "diarrhoea", ",", "C0011991#ent", "<e2>", "flatulence", "."], "h": {"id": "C0055729", "name": "C0055729#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [13, 14]}}
{"token": ["The", "overexpression", "of", "C1335222#ent", "<e1>", "into", "SNU-216", "cells", "significantly", "increased", "the", "activity", "of", "C1522670#ent", "<e2>", "uPA", ")", ",", "and", "the", "expressions", "of", "uPA", "and", "urokinase-type", "plasminogen", "activator", "receptor", "uPAR", ")", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1522670", "name": "C1522670#ent", "pos": [13, 14]}}
{"token": ["This", "work", "describes", "the", "proliferation", "index", "C1705526#ent", "<e1>", "expression", "by", "immunohistochemistry", "in", "C0207890#ent", "<e2>", "of", "PCMycosis", ",", "normal", "oral", "mucosa", "NOM", ")", "and", "mild", "oral", "epithelial", "dysplasia", "ED", ")", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0207890", "name": "C0207890#ent", "pos": [12, 13]}}
{"token": ["We", "report", "two", "cases", "of", "cutaneous", "primary", "melanoma", "associated", "with", "C0207890#ent", "<e1>", "and", "discuss", "differential", "diagnoses", "potential", "role", "of", "C1705526#ent", "<e2>", "and", "bcl-2", "in", "the", "pathogenesis", "of", "C0207890#ent", "<e1>", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0207890", "name": "C0207890#ent", "pos": [10, 11]}}
{"token": ["Only", "C0220918#ent", "<e1>", "and", "glycerol", "phosphate", "but", "not", "C0068803#ent", "<e2>", "were", "capable", "of", "stimulating", "oxygen", "consumption"], "h": {"id": "C0220918", "name": "C0220918#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0068803", "name": "C0068803#ent", "pos": [8, 9]}}
{"token": ["Periodontitis", "is", "a", "C1290884#ent", "<e1>", "by", "a", "small", "group", "C0085423#ent", "<e2>", "of", "which", "Porphyromonas", "gingivalis", "considered", "an", "important", "causative", "agent"], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [9, 10]}}
{"token": ["Focal", "intracranial", "infections", "i.e.", ",", "brain", "abscess", "C0270629#ent", "<e1>", "may", "occur", "in", "the", "absence", "of", "C0014121#ent", "<e2>", "resulting", "from", "bacteremia", "that", "seeds", "the", "brain", "or", "epidural", "space"], "h": {"id": "C0270629", "name": "C0270629#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [15, 16]}}
{"token": ["The", "most", "variable", "C0086376#ent", "<e1>", "in", "the", "African", "isolates", "were", "p150", ",", "p27", ",", "C1540306#ent", "<e2>", ",", "and", "p12", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1540306", "name": "C1540306#ent", "pos": [14, 15]}}
{"token": ["In", "the", "pentoxifylline", "group", "17.6", "%", "of", "patients", "complained", "of", "C0038354#ent", "<e1>", "nausea", ",", "vomiting", ",", "C0013395#ent", "<e2>", ")", ",", "or", "of", "headache", "and", "dizziness", "."], "h": {"id": "C0038354", "name": "C0038354#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", "to", "disruptions", "of", "the", "HST7", "and", "C1417075#ent", "<e1>", "disruption", "of", "the", "CEK1", "C0079429#ent", "<e2>", "adversely", "affects", "the", "growth", "of", "serum-induced", "mycelial", "colonies", "and", "attenuates", "virulence", "in", "a", "mouse", "model", "systemic", "candidiasis"], "h": {"id": "C1417075", "name": "C1417075#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}}
{"token": ["Captopril", "and", "C0020261#ent", "<e1>", "increased", "plasma", "renin", "activity", "C3274822#ent", "<e2>", ")", "but", "only", "the", "combination", "of", "captopril", "and", "C0020261#ent", "<e1>", "produced", "a", "greater", "and", "longer", "lasting", "increase", "of", "C3274822#ent", "<e2>", "."], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [2, 3]}}
{"token": ["C0234535#ent", "<e1>", "induced", "by", "C0005372#ent", "<e2>", "(", "4", "mg/kg", "i.p", ".", ")"], "h": {"id": "C0234535", "name": "C0234535#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005372", "name": "C0005372#ent", "pos": [4, 5]}}
{"token": ["In", "the", "C1706158#ent", "<e1>", "mouse", "model", "collagen-induced", "arthritis", "CIA", ")", ",", "animals", "receiving", "oral", "treatment", "C2351061#ent", "<e2>", "(", "50", "mg/kg", ")", ",", "beginning", "at", "onset", "of", "disease", "significantly", "decreased", "CIA", "peak", "scores", "daily", "severity", "of", "arthritis", "scores"], "h": {"id": "C1706158", "name": "C1706158#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2351061", "name": "C2351061#ent", "pos": [15, 16]}}
{"token": ["We", "compared", "the", "cocaine", "and", "C0360097#ent", "<e1>", "affinities", "of", "human", "cardiac", "(", "C1419864#ent", "<e2>", ")", "and", "rat", "skeletal", "(", "mu", "1", ")", "muscle", "Na", "channels", "were", "transiently", "expressed", "in", "HEK", "293t", "cells"], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419864", "name": "C1419864#ent", "pos": [12, 13]}}
{"token": ["We", "also", "found", "that", "C1622105#ent", "<e1>", "increased", "two", "IL-4", "relevant", "transcription", "factors", "AP-1", ")", "and", "C2985455#ent", "<e2>", "."], "h": {"id": "C1622105", "name": "C1622105#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2985455", "name": "C2985455#ent", "pos": [15, 16]}}
{"token": ["The", "inactivation", "of", "the", "C1705516#ent", "<e1>", "activities", "by", "both", "DAG", "and", "C0083534#ent", "<e2>", "in", "preincubations", "required", "the", "presence", "of", "oxygen", "and", "Ca2", "+", ",", "consistent", "with", "inactivation", "mechanism", "that", "requires", "active", "metabolism", "C1705516#ent", "<e1>", "."], "h": {"id": "C1705516", "name": "C1705516#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0083534", "name": "C0083534#ent", "pos": [11, 12]}}
{"token": ["C1420690#ent", "<e1>", "interacts", "with", "C1420540#ent", "<e2>", ",", "which", "is", "an", "integral", "component", "of", "the", "synaptonemal", "complex", "lateral", "elements"], "h": {"id": "C1420690", "name": "C1420690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420540", "name": "C1420540#ent", "pos": [4, 5]}}
{"token": ["In", "contrast", "to", "C1366566#ent", "<e1>", ",", "increased", "expression", "of", "C1332821#ent", "<e2>", ",", "CXCL10", ",", "and", "CXCL11", "could", "only", "be", "observed", "during", "the", "clinically", "inflammatory", "phase", "ACD", "."], "h": {"id": "C1366566", "name": "C1366566#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332821", "name": "C1332821#ent", "pos": [9, 10]}}
{"token": ["An", "histological", "analysis", "Kveim-test", "biopsies", "performed", "on", "a", "total", "of", "306", "patients", "including", "those", "with", "sarcoidosis", ",", "C0156147#ent", "<e1>", "tuberculosis", ",", "and", "C0009326#ent", "<e2>", "presented", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [22, 23]}}
{"token": ["Transcription", "factor", "SP1", ",", "and", "retinoblastoma", "susceptible", "gene", "product", "RB", ",", "are", "substrates", "of", "C0169097#ent", "<e1>", "while", "other", "nuclear", "factors", "as", "C1623430#ent", "<e2>", "and", "c-Fos", "are", "not", "."], "h": {"id": "C0169097", "name": "C0169097#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [21, 22]}}
{"token": ["When", "C3889446#ent", "<e1>", "in", "human", "293", "cells", "C1336666#ent", "<e2>", "activates", "NF-kappaB.", "A", "dominant-negative", "mutant", "of", "C1336666#ent", "<e2>", "inhibits", "NF-kappaB", "activation", "by", "interleukin-1", "(", "IL-1", ")", "but", "not", "by", "TNF", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1336666", "name": "C1336666#ent", "pos": [7, 8]}}
{"token": ["Circulation", "disturbances", "in", "the", "cauda", "equina", "nerve", "roots", "been", "implicated", "in", "the", "genesis", "of", "C0021775#ent", "<e1>", "NIC", ")", "in", "patients", "with", "C0158288#ent", "<e2>", "LSS", ")", "."], "h": {"id": "C0021775", "name": "C0021775#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0158288", "name": "C0158288#ent", "pos": [21, 22]}}
{"token": ["Oligonucleotide", "primer", "pairs", "selected", "that", "allowed", "the", "C0079941#ent", "<e1>", "the", "human", "C2982484#ent", "<e2>", "gene", "to", "be", "amplified", "by", "PCR", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "pentaformilgitoxin", "and", "C0011689#ent", "<e1>", "on", "heart", "rate", "blood", "pressure", "cardiac", "output", "compared", "in", "six", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0011689", "name": "C0011689#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [19, 20]}}
{"token": ["A", "proteomics", "screen", "of", "human", "placental", "microvillous", "syncytiotrophoblasts", "STBs", ")", "revealed", "the", "expression", "of", "C1414209#ent", "<e1>", "(", "DYSF", ")", ",", "a", "plasma", "membrane", "repair", "protein", "associated", "with", "C0751336#ent", "<e2>"], "h": {"id": "C1414209", "name": "C1414209#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C0751336", "name": "C0751336#ent", "pos": [27, 28]}}
{"token": ["Dysferlin", "immunohistochemical", "and", "Western", "blot", "analyses", "us", "to", "identify", "six", "patients", "with", "C1414209#ent", "<e1>", "one", "with", "C0751336#ent", "<e2>", "four", "with", "limb", "girdle", "myopathy", "one", "with", "hyperCKemia", "."], "h": {"id": "C1414209", "name": "C1414209#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0751336", "name": "C0751336#ent", "pos": [16, 17]}}
{"token": ["Five", "of", "them", "show", "COX-2", "inhibition", "close", "to", "that", "of", "C0132515#ent", "<e1>", "and", "rofecoxib", ",", "two", "reference", "COX-2", "C1517755#ent", "<e2>"], "h": {"id": "C0132515", "name": "C0132515#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1517755", "name": "C1517755#ent", "pos": [18, 19]}}
{"token": ["C1800706#ent", "<e1>", "patients", "with", "high", "concentrations", "of", "C0751783#ent", "<e2>", "myeloperoxidase", "deteriorated", "more", "rapidly", "than", "those", "with", "low", "ELF", "myeloperoxidase", "(", "P", "less", "than", "0.05", ")", "."], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751783", "name": "C0751783#ent", "pos": [7, 8]}}
{"token": ["The", "majority", "of", "C1800706#ent", "<e1>", "patients", "had", "C0751783#ent", "<e2>", "myeloperoxidase", "levels", "normal", "(", "P", "less", "than", "0.002", ")", "."], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751783", "name": "C0751783#ent", "pos": [7, 8]}}
{"token": ["Cytotoxicity", "of", "the", "AKD", "cells", "was", "markedly", "increased", "when", "the", "C1800706#ent", "<e1>", "inflammatory", "cells", "incubated", "with", "autologous", "C0751783#ent", "<e2>", "(", "P", "less", "than", "0.02", ")", "."], "h": {"id": "C1800706", "name": "C1800706#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751783", "name": "C0751783#ent", "pos": [17, 18]}}
{"token": ["Binding", "of", "C3888044#ent", "<e1>", "with", "LSP", "required", "prior", "presence", "of", "C1419212#ent", "<e2>", "on", "the", "phagosome", "."], "h": {"id": "C3888044", "name": "C3888044#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419212", "name": "C1419212#ent", "pos": [10, 11]}}
{"token": ["Since", "there", "are", "few", "rapid", "diagnostic", "tests", "for", "screening", "Campylobacter", "C1875400#ent", "<e1>", ",", "we", "hope", "that", "the", "rapid", "C0020284#ent", "<e2>", "prove", "useful", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020284", "name": "C0020284#ent", "pos": [18, 19]}}
{"token": ["These", "antinociceptive", "effects", "were", "reversed", "by", "microinjections", "of", "the", "opioid", "antagonist", "C0027360#ent", "<e1>", "or", "the", "specific", "5-HT2A", "receptor", "antagonist", "C0022616#ent", "<e2>", "into", "the", "stimulation", "sites"], "h": {"id": "C0027360", "name": "C0027360#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [19, 20]}}
{"token": ["Hypercapnic", "acidosis", "by", "reduced", "tidal", "volumes", "C1631597#ent", "<e1>", ")", "was", "associated", "with", "increased", "shunt", "fraction", "C3642267#ent", "<e2>", ")", "in", "patients", "with", "ALI", "compared", "with", "control", "subjects"], "h": {"id": "C1631597", "name": "C1631597#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3642267", "name": "C3642267#ent", "pos": [15, 16]}}
{"token": ["The", "C1419064#ent", "<e1>", "agonist-induced", "endothelial", "cell", "migration", "inhibited", "by", "ERK", ",", "but", "not", "C0243459#ent", "<e2>", "defining", "a", "functional", "link", "between", "PGE(2)-induced", "endothelial", "cell", "migration", "and", "EP4-mediated", "ERK", "signaling", "."], "h": {"id": "C1419064", "name": "C1419064#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243459", "name": "C0243459#ent", "pos": [13, 14]}}
{"token": ["Plasma", "testosterone", "levels", "were", "related", "to", "the", "dose", "of", "injected", "C1416805#ent", "<e1>", ",", "but", "were", "not", "influenced", "by", "photoperiod", "or", "C0032002#ent", "<e2>"], "h": {"id": "C1416805", "name": "C1416805#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [20, 21]}}
{"token": ["The", "activity", "of", "C1870412#ent", "<e1>", "and", "the", "amount", "of", "the", "protein", "found", "in", "the", "C0008546#ent", "<e2>", "was", "increased", "only", "at", "20", "h", "after", "partial", "hepatectomy", "."], "h": {"id": "C1870412", "name": "C1870412#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [14, 15]}}
{"token": ["Autoantibodies", "against", "ssDNA", ",", "dsDNA", ",", "cardiolipin", ",", "actin", ",", "C0027096#ent", "<e1>", ",", "tropomyosin", ",", "GM1", ",", "GD1b", "and", "GT3", "C0017082#ent", "<e2>", ",", "were", "detected", "with", "an", "enzyme-linked", "immunoassay", "ELISA", ")", "."], "h": {"id": "C0027096", "name": "C0027096#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017082", "name": "C0017082#ent", "pos": [20, 21]}}
{"token": ["In", "order", "to", "find", "out", "a", "possible", "relation", "between", "C1709111#ent", "<e1>", "reference", "values", "the", "risks", "of", "C0403719#ent", "<e2>", ",", "lithogenous", "and", "inhibitory", "substances", "were", "determined", "in", "both", "groups", "."], "h": {"id": "C1709111", "name": "C1709111#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0403719", "name": "C0403719#ent", "pos": [16, 17]}}
{"token": ["The", "occurrence", "of", "headache", ",", "dysthymia", "and", "signs", "of", "C0031117#ent", "<e1>", "significantly", "higher", "in", "patients", "with", "C0007570#ent", "<e2>", "in", "control", "subjects"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [16, 17]}}
{"token": ["Densitometry", "of", "the", "autoradiographs", "was", "used", "to", "determine", "the", "ratio", "of", "the", "copy-number", "of", "the", "21-hydroxylase", "gene", "C1522419#ent", "<e1>", ")", "to", "the", "copy-number", "of", "its", "pseudogene", "(", "C1413861#ent", "<e2>", ")", "."], "h": {"id": "C1522419", "name": "C1522419#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413861", "name": "C1413861#ent", "pos": [27, 28]}}
{"token": ["Long", "(", "20", "h", ")", "treatment", "with", "troglitazone", "caused", "a", "sustained", "phosphorylation", "of", "AMPK", "and", "C0001022#ent", "<e1>", "and", "increased", "GSIS", "after", "withdrawal", "of", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C0001022", "name": "C0001022#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [24, 25]}}
{"token": ["Consistent", "with", "analysis", "of", "Streptomyces", "genomes", "most", "of", "the", "C1134446#ent", "<e1>", "genes", "in", "N.", "farcinica", "were", "involved", "in", "various", "'", "C1334046#ent", "<e2>", "'", "functions", "important", "for", "cell", "growth"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334046", "name": "C1334046#ent", "pos": [20, 21]}}
{"token": ["A", "transcriptional", "fusion", "a", "157-bp", "DNA", "fragment", ",", "containing", "the", "apparent", "SOS", "box", "upstream", "of", "the", "regA", "gene", ",", "and", "the", "C1366498#ent", "<e1>", "increased", "chloramphenicol", "acetyltransferase", "upon", "C0026254#ent", "<e2>", "treatment", "."], "h": {"id": "C1366498", "name": "C1366498#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [27, 28]}}
{"token": ["P-450NF", "is", "the", "major", "C0027203#ent", "<e1>", "in", "human", "liver", "involved", "in", "the", "metabolism", "of", "the", "C0006684#ent", "<e2>", "nifedipine", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [15, 16]}}
{"token": ["C0031069#ent", "<e1>", "is", "characterized", "by", "recurrent", "attacks", "fever", "and", "peritonitis", ",", "C0032231#ent", "<e2>", ",", "arthritis", "or", "erysipelas-like", "erythema", "."], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0032231", "name": "C0032231#ent", "pos": [11, 12]}}
{"token": ["The", "syndromes", "may", "result", "both", "from", "organic", "diseases", "inflammatory", "joint", "diseases", "C0029166#ent", "<e1>", "organ", "diseases", "as", "well", "as", "C4055108#ent", "<e2>", "the", "latter", "including", "mainly", "biomechanically", "induced", "syndromes", "and", "fibromyalgia", "."], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4055108", "name": "C4055108#ent", "pos": [18, 19]}}
{"token": ["Inhibition", "of", "adipocyte", "differentiation", "by", "1,25(OH)2D3", "is", "ameliorated", "by", "troglitazone", ",", "a", "specific", "PPARgamma", "antagonist", "conversely", ",", "C3536983#ent", "<e1>", "partially", "suppresses", "the", "transacting", "activity", "C1335238#ent", "<e2>", "but", "not", "of", "C/EBPbeta", "or", "C/EBPalpha", "."], "h": {"id": "C3536983", "name": "C3536983#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [24, 25]}}
{"token": ["C0030864#ent", "<e1>", "discovered", "to", "have", "C0003416#ent", "<e2>", "1938", ",", "has", "recently", "been", "approved", "in", "the", "United", "States", "the", "treatment", "of", "Pneumocystis", "carinii", "pneumonia", "."], "h": {"id": "C0030864", "name": "C0030864#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003416", "name": "C0003416#ent", "pos": [5, 6]}}
{"token": ["C0043194#ent", "<e1>", "a", "rare", "X-linked", "disorder", "comprising", "the", "C0013595#ent", "<e2>", "thrombocytopenia", "and", "progressive", "immunodeficiency", "."], "h": {"id": "C0043194", "name": "C0043194#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [8, 9]}}
{"token": ["We", "found", "significant", "and", "conserved", "sequence", "in", "the", "PSST/Nqo6/NuoB", ",", "49kDa/Nqo4/NuoD", ",", "and", "ND1/Nqo8/NuoH", "subunit", "C4277608#ent", "<e1>", "between", "complex", "I/NDH-1", "and", "[", "NiFe", "]", "C0020284#ent", "<e2>", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020284", "name": "C0020284#ent", "pos": [24, 25]}}
{"token": ["It", "was", "concluded", "that", "C0008932#ent", "<e1>", "chickens", "require", "increased", "C0012177#ent", "<e2>", "maintain", "maximal", "growth", ",", "and", "that", "increased", "protein", "consumption", "an", "important", "factor", "in", "improving", "growth", "in", "clenbuterol-fed", "broilers", "."], "h": {"id": "C0008932", "name": "C0008932#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012177", "name": "C0012177#ent", "pos": [9, 10]}}
{"token": ["Both", "cell", "types", "SLC7A1", "(", "CAT1", ")", "and", "C1442752#ent", "<e1>", "(", "CAT2B", "and", "CAT2A", ")", "as", "well", "as", "SLC7A6", "(", "C3889157#ent", "<e2>", ")", "and", "SLC7A7", "(", "y+LAT1", ")", "."], "h": {"id": "C1442752", "name": "C1442752#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3889157", "name": "C3889157#ent", "pos": [20, 21]}}
{"token": ["To", "protect", "against", "this", "process", "may", "require", "both", "thromboxane", "and", "serotonin", "receptor", "antagonists", "or", "a", "combination", "of", "C0040060#ent", "<e1>", "and", "receptor", "antagonist", "a", "C3536755#ent", "<e2>"], "h": {"id": "C0040060", "name": "C0040060#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3536755", "name": "C3536755#ent", "pos": [23, 24]}}
{"token": ["We", "show", "that", "ESET", "C0062776#ent", "<e1>", "associates", "with", "histone", "deacetylase", "1", "HDAC1", ")", "and", "C0768528#ent", "<e2>", ",", "and", "that", "ESET", "also", "interacts", "with", "the", "transcription", "co-repressors", "and", "mSin3B", "."], "h": {"id": "C0062776", "name": "C0062776#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0768528", "name": "C0768528#ent", "pos": [14, 15]}}
{"token": ["We", "have", "presented", "a", "case", "of", "\"", "C1306804#ent", "<e1>", "\"", "a", "syndrome", "of", "transient", "C0020550#ent", "<e2>", "with", "low", "131I", "uptake", "and", "no", "local", "thyroid", "gland", "symptoms", "."], "h": {"id": "C1306804", "name": "C1306804#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020550", "name": "C0020550#ent", "pos": [14, 15]}}
{"token": ["Loss", "of", "C1420400#ent", "<e1>", "correlates", "with", "impaired", "expression", "of", "the", "antiapoptotic", "Bcl-2", "and", "C1332397#ent", "<e2>"], "h": {"id": "C1420400", "name": "C1420400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [13, 14]}}
{"token": ["No", "mutations", "were", "observed", "in", "the", "c-K-ras", "gene", "the", "C0079056#ent", "<e1>", "nine", "azaserine-induced", "adenomas", "and", "15", "carcinomas", "of", "the", "rat", "C0771711#ent", "<e2>", "."], "h": {"id": "C0079056", "name": "C0079056#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [20, 21]}}
{"token": ["injection", "of", "the", "M1", "receptor", "antagonist", "C0031978#ent", "<e1>", "in", "a", "dose-dependent", "manner", ",", "and", "by", "the", "C0019593#ent", "<e2>", "4-DAMP", ",", "but", "not", "by", "the", "M2", "receptor", "antagonist", "methoctramine", "."], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "C0031978#ent", "<e1>", ",", "a", "muscarinic", "antagonist", "and", "cimetidine", ",", "a", "C0019593#ent", "<e2>", "on", "2-deoxy-D-glucose-stimulated", "gastric", "secretion", "investigated", "in", "the", "gastric-fistula", "cat", "."], "h": {"id": "C0031978", "name": "C0031978#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", "increased", "serotonergic", "activity", "may", "be", "involved", "in", "the", "induction", "of", "subsensitivity", "of", "the", "C0001644#ent", "<e1>", "rat", "brain", "by", "C0074393#ent", "<e2>", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0074393", "name": "C0074393#ent", "pos": [22, 23]}}
{"token": ["Urinary", "transferrin", ",", "serum", "prostatic", "acid", "phosphatase", "PAP", ")", "and", "prostatic-specific", "antigen", "C1366489#ent", "<e1>", ")", "concentrations", "were", "measured", "in", "patients", "with", "prostatic", "cancer", "C0149524#ent", "<e2>", ",", "benign", "prostatic", "hypertrophy", "BPH", ")", "and", "in", "a", "control", "group"], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0149524", "name": "C0149524#ent", "pos": [23, 24]}}
{"token": ["It", "appeared", "that", "after", "24", "h", ",", "both", "C1414967#ent", "<e1>", "and", "NF", "levels", "were", "elevated", "in", "the", "C0002736#ent", "<e2>", "sera-treated", "cells", "by", "12", "and", "11", "%", ",", "respectively", "."], "h": {"id": "C1414967", "name": "C1414967#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [17, 18]}}
{"token": ["Several", "studies", "have", "convincingly", "established", "that", "somatostatin", "receptor", "scintigraphy", "benefits", "patients", "with", "a", "number", "of", "C1290886#ent", "<e1>", "including", "sarcoidosis", "and", "other", "C0018203#ent", "<e2>"], "h": {"id": "C1290886", "name": "C1290886#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018203", "name": "C0018203#ent", "pos": [21, 22]}}
{"token": ["We", "identified", "HISTONE", "MONOUBIQUITINATION1", "C1421768#ent", "<e1>", ")", "(", "and", "its", "C1334043#ent", "<e2>", "HUB2", ")", "in", "Arabidopsis", "thaliana", "RING", "E3", "ligase", "proteins", "a", "function", "in", "organ", "growth"], "h": {"id": "C1421768", "name": "C1421768#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}}
{"token": ["V1", "receptor-mediated", "functions", "(", "increase", "in", "urinary", "prostaglandin", "E2", "excretion", "and", "plasma", "cortisol", "levels", "and", "C1705766#ent", "<e1>", "(", "guanine", "nucleotide-binding", "stimulatory", "protein", "activity", "of", "C1420193#ent", "<e2>", "normal", "in", "both", "patients", "."], "h": {"id": "C1705766", "name": "C1705766#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [24, 25]}}
{"token": ["A", "small", "GTPase", "C1366537#ent", "<e1>", "was", "a", "potential", "downstream", "target", "of", "GalNAc-S-activated", "C0010531#ent", "<e2>", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}}
{"token": ["Hepatitis", "C", "virus", "HCV", ")", "genome", "reported", "by", "the", "C0914797#ent", "<e1>", "is", "supposed", "to", "have", "structural", "proteins", "core", ",", "matrix", ",", "C0017343#ent", "<e2>", "and", "non-structural", "proteins", "NS", "1", "5", "from", "5", "'", "to", "3", "'", "end", "."], "h": {"id": "C0914797", "name": "C0914797#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017343", "name": "C0017343#ent", "pos": [21, 22]}}
{"token": ["The", "agents", "reviewed", "are", "carisoprodol", ",", "methocarbamol", ",", "chlorphenesin", "carbamate", "metaxalone", ",", "chloroxazone", ",", "C0029310#ent", "<e1>", "diazepam", ",", "and", "C0125988#ent", "<e2>", "."], "h": {"id": "C0029310", "name": "C0029310#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0125988", "name": "C0125988#ent", "pos": [19, 20]}}
{"token": ["We", "show", "under", "basal", "nonapoptotic", "conditions", "that", "C2986464#ent", "<e1>", "constitutively", "occupies", "and", "transcriptionally", "silences", "C1412812#ent", "<e2>", "gene", "transcription", "competing", "with", "E2F-1", "for", "C1412812#ent", "<e2>", "promoter", "binding"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412812", "name": "C1412812#ent", "pos": [14, 15]}}
{"token": ["Mannan", ",", "but", "not", "beta-glucan", "or", "C0218497#ent", "<e1>", ",", "prevented", "sensitive", "yeast", "cells", "being", "killed", "by", "the", "C1336644#ent", "<e2>", "suggesting", "that", "mannan", "may", "bind", "to", "the", "C1336644#ent", "<e2>"], "h": {"id": "C0218497", "name": "C0218497#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336644", "name": "C1336644#ent", "pos": [17, 18]}}
{"token": ["Inhibition", "of", "ERBB1", "function", "using", "Iressa", "(", "C1122962#ent", "<e1>", ")", "or", "the", "C0600438#ent", "<e2>", "AG1478", "had", "more", "modest", "effects", "at", "enhancing", "DCA", "lethality", "than", "inhibition", "of", "the", "insulin/IGF-1", "receptor", "function", "."], "h": {"id": "C1122962", "name": "C1122962#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600438", "name": "C0600438#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "C1259877#ent", "<e1>", "PKC", ")", "has", "been", "reported", "to", "inhibit", "C1539477#ent", "<e2>", "(", "APO-1", ",", "CD95)-mediated", "apoptosis", "in", "different", "cellular", "systems"], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [11, 12]}}
{"token": ["A", "significant", "decrease", "in", "C0026691#ent", "<e1>", "was", "observed", "when", "the", "ligand", "was", "elongated", "from", "C0012512#ent", "<e2>", "to", "tripeptide", "."], "h": {"id": "C0026691", "name": "C0026691#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012512", "name": "C0012512#ent", "pos": [14, 15]}}
{"token": ["The", "ability", "of", "antiestrogens", "(", "C0039286#ent", "<e1>", "and", "nafoxidine", ")", "to", "affect", "uterine", "ornithine", "decarboxylase", "C1417932#ent", "<e2>", ")", "in", "the", "ovariectomized", "rat", "was", "determined", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [15, 16]}}
{"token": ["The", "first", "case", "of", "pylephlebitis", "(", "septic", "portal", "vein", "thrombosis", "and", "C0034212#ent", "<e1>", "liver", "abscess", "hemorrhoidal", "banding", "a", "49-year-old", "man", "with", "C0011847#ent", "<e2>", "is", "reported", "in", "the", "present", "study", "."], "h": {"id": "C0034212", "name": "C0034212#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [21, 22]}}
{"token": ["Equilibrium", "binding", "studies", "that", "C0597298#ent", "<e1>", "bound", "to", "bladder", "membrane", "receptors", "specifically", ",", "with", "high", "affinity", "C1839259#ent", "<e2>", "of", "0.4", "-", "0.6", "nM", ")", "and", "limited", "capacity", "(", "60", "-", "420", "fmol/mg", "protein", ")", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "C0991617#ent", "<e1>", "that", "manipulate", "C0242704#ent", "<e2>", "and", "glutaminergic", "receptors", "being", "studied", "as", "possible", "non-stimulant", "alternatives", "in", "the", "management", "of", "adult", "ADHD", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242704", "name": "C0242704#ent", "pos": [7, 8]}}
{"token": ["The", "labeling", "observed", "in", "amino", "acids", "from", "C0000975#ent", "<e1>", "is", "in", "agreement", "with", "the", "function", "of", "these", "C3540790#ent", "<e2>", "in", "biosynthesis", "and", "indicates", "that", "the", "majority", "of", "acetate", "carbon", "into", "amino", "acid", "biosynthesis", "well-known", "pathways", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [17, 18]}}
{"token": ["Aeration", "of", "these", "cells", ",", "in", "buffer", "containing", "C0000975#ent", "<e1>", ",", "initiates", "the", "formation", "of", "the", "three", "C3540790#ent", "<e2>", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [17, 18]}}
{"token": ["1966.-A", "proposed", "system", "which", "would", "permit", "C0000975#ent", "<e1>", "incorporation", "into", "four-carbon", "compounds", "without", "the", "presence", "of", "key", "C3540790#ent", "<e2>", "of", "the", "citric", "acid", "cycle", "glyoxylate", "cycle", "described", "."], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [17, 18]}}
{"token": ["The", "neoplasm", "presented", "as", "a", "C0030193#ent", "<e1>", ",", "pericoronal", "gingival", "swelling", "that", "mimicked", "an", "C1333274#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333274", "name": "C1333274#ent", "pos": [14, 15]}}
{"token": ["The", "special", "studies", "EEG", ",", "C1705631#ent", "<e1>", ",", "determination", "of", "catecholamine", "excretion", ")", "showed", "that", "C0392617#ent", "<e2>", "paroxysmal", "vegetative", "disturbances", "depend", "on", "the", "state", "of", "brain", "circulation", "functional", "activity", "of", "the", "sympathetico-adrenal", "system", "."], "h": {"id": "C1705631", "name": "C1705631#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0392617", "name": "C0392617#ent", "pos": [15, 16]}}
{"token": ["Anthelmintic", "therapies", "C0086227#ent", "<e1>", "are", "successful", "and", "include", "mebendazole", ",", "C0001911#ent", "<e2>", "and", "pyrantel", "pamoate"], "h": {"id": "C0086227", "name": "C0086227#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0001911", "name": "C0001911#ent", "pos": [10, 11]}}
{"token": ["Fanconi", "anemia", "group", "L", "FANCL", ")", "is", "a", "novel", "C0015625#ent", "<e1>", "which", "mono-ubiquitinates", "FANCD2", "as", "a", "C0077678#ent", "<e2>", "and", "plays", "a", "crucial", "role", "in", "DNA", "damage", "repair", "chromosome", "stability", "maintenance", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [16, 17]}}
{"token": ["Locus-specific", "FISH", "targeting", "a", "growth", "factor", "receptor", "binding", "protein", "10", "C1366512#ent", "<e1>", ")", ",", "the", "strong", "candidate", "for", "C1419767#ent", "<e2>", "residing", "at", "7p12.2", ",", "showed", "that", "it", "is", "not", "duplicated", "in", "our", "patients", "."], "h": {"id": "C1366512", "name": "C1366512#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419767", "name": "C1419767#ent", "pos": [18, 19]}}
{"token": ["The", "results", "are", "discussed", "in", "relation", "to", "the", "accredited", "role", "of", "C1412726#ent", "<e1>", "thermogenesis", "in", "rodents", "exposed", "to", "C0041912#ent", "<e2>", "."], "h": {"id": "C1412726", "name": "C1412726#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [18, 19]}}
{"token": ["Among", "the", "known", "Rho", "GTPases", "expressed", "in", "NIH", "3T3", "cells", "C0084340#ent", "<e1>", "was", "predominantly", "activated", "by", "oncogenic", "C3640214#ent", "<e2>", "in", "vivo"], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3640214", "name": "C3640214#ent", "pos": [17, 18]}}
{"token": ["There", ",", "p0071", "interacted", "directly", "with", "C0084340#ent", "<e1>", "itself", "and", "with", "the", "Rho-GEF", "C3640214#ent", "<e2>", "."], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3640214", "name": "C3640214#ent", "pos": [13, 14]}}
{"token": ["ATP", ",", "ADP", ",", "C1706611#ent", "<e1>", "and", "cyclic", "AMP", "inhibit", "NAD-dependent", "isocitrate", "dehydrogenase", "L-s-isocitrate", ":", "NAD-+", "C0030016#ent", "<e2>", ",", "EC", "1.1.1.41", ")", "from", "rhizobia", "but", "have", "no", "effect", "the", "enzyme", "from", "corresponding", "bacteroids", "."], "h": {"id": "C1706611", "name": "C1706611#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [16, 17]}}
{"token": ["The", "homologous", "tyrosine", "JAK3", ",", "tyrosine", "785", ",", "is", "autophosphorylated", "in", "response", "to", "C1522405#ent", "<e1>", "is", "required", "for", "C1709985#ent", "<e2>", "beta", "to", "bind", "JAK3", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1709985", "name": "C1709985#ent", "pos": [18, 19]}}
{"token": ["Current", "analgesic", "therapeutic", "first-line", "strategies", "for", "C0036396#ent", "<e1>", "on", "NSAIDs", "that", "are", "known", "to", "relieve", "C3178766#ent", "<e2>", "."], "h": {"id": "C0036396", "name": "C0036396#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3178766", "name": "C3178766#ent", "pos": [15, 16]}}
{"token": ["In", "these", "pregnancies", "prevention", "of", "C0151517#ent", "<e1>", "with", "plasmapheresis", "plus", "C0011777#ent", "<e2>", "during", "pregnancy", "may", "be", "possible", "."], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [10, 11]}}
{"token": ["The", "antiemetic", "efficacy", "of", "C0033487#ent", "<e1>", "combined", "with", "C0011777#ent", "<e2>", "was", "superior", "to", "that", "of", "C0033487#ent", "<e1>", "alone", "(", "p=0.04", ")", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [4, 5]}}
{"token": ["C0669372#ent", "<e1>", "was", "detected", "in", "inflammatory", "cells", "all", "types", "of", "C0017152#ent", "<e2>", "with", "or", "without", "H.", "pylori", "infection", "independently", "of", "its", "severity", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [10, 11]}}
{"token": ["We", "have", "generated", "a", "novel", "\"", "receptor", "tyrosine", "kinase", "by", "fusing", "the", "extracellular", "and", "transmembrane", "domain", "the", "mouse", "platelet-derived", "growth", "factor", "receptor", "C1705320#ent", "<e1>", ")", "to", "the", "cytoplasmic", "domain", "C1332714#ent", "<e2>", "and", "coexpressing", "the", "construct", "with", "the", "murine", "cytoplasmic", "tyrosine", "protein", "kinase", "p56lck"], "h": {"id": "C1705320", "name": "C1705320#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1332714", "name": "C1332714#ent", "pos": [29, 30]}}
{"token": ["The", "effect", "of", "C0023556#ent", "<e1>", "as", "well", "as", "thymic", "(", "thymalin", "and", "bone", "marrow", "C0062203#ent", "<e2>", ")", "immunomodulators", "on", "the", "immunogenesis", "organs", "in", "practically", "healthy", "animals", "studied", "."], "h": {"id": "C0023556", "name": "C0023556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0062203", "name": "C0062203#ent", "pos": [14, 15]}}
{"token": ["Expression", "of", "C1421976#ent", "<e1>", "under", "the", "control", "of", "the", "C1706044#ent", "<e2>", "promoter", "indicated", "a", "spatial", "localization", "C1706044#ent", "<e2>", "in", "the", "anterior-like", "and", "prestalk", "cell", "types"], "h": {"id": "C1421976", "name": "C1421976#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [9, 10]}}
{"token": ["Postischemic", "AK1", "knockout", "hearts", "maintained", "approximately", "40", "%", "of", "beta-phosphoryl", "turnover", ",", "suggesting", "increased", "C0031727#ent", "<e1>", "flux", "through", "remaining", "C0001497#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001497", "name": "C0001497#ent", "pos": [19, 20]}}
{"token": ["Examination", "of", "C1332712#ent", "<e1>", "isoforms", "revealed", "that", "C3815268#ent", "<e2>", "exposure", "altered", "C1332712#ent", "<e1>", "variant", "7", "(", "v7", ")", "isoform", "expression", "."], "h": {"id": "C3815268", "name": "C3815268#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332712", "name": "C1332712#ent", "pos": [2, 3]}}
{"token": ["Tetralogy", "of", "C3541422#ent", "<e1>", "(", "TF", ")", "is", "a", "congenital", "conotruncal", "heart", "defect", "found", "in", "C0012236#ent", "<e2>", "(", "DGS", ")", "and", "velo-cardio-facial", "(", "VCFS", ")", "syndromes", "."], "h": {"id": "C3541422", "name": "C3541422#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012236", "name": "C0012236#ent", "pos": [15, 16]}}
{"token": ["Inhibitors", "of", "protein", "phosphatase", "1", "PP1", ")", ",", "protein", "kinase", "C", "PKC", ")", ",", "protein", "tyrosine", "kinase", "C1335273#ent", "<e1>", ")", ",", "calmodulin", "and", "calmodulin-dependent", "kinase-II", "C3541431#ent", "<e2>", "prevented", "LFA-1", "expression", "on", "cisplatin-treated", "macrophages", "."], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3541431", "name": "C3541431#ent", "pos": [25, 26]}}
{"token": ["Previously", "we", "have", "shown", "that", "the", "imino", "sugar", "inhibitor", "of", "N-linked", "glycan", "processing", ",", "C0674666#ent", "<e1>", "(", "N-nonyl-DNJ", ")", ",", "had", "antiviral", "activity", "the", "woodchuck", "model", "C0276623#ent", "<e2>", "HBV", ")", "infection", "."], "h": {"id": "C0674666", "name": "C0674666#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0276623", "name": "C0276623#ent", "pos": [26, 27]}}
{"token": ["In", "UGC", ",", "PGE2", "increased", "C0003805#ent", "<e1>", "mRNA", "and", "Cyp19", "protein", "whereas", "C0058310#ent", "<e2>", "had", "no", "effect"], "h": {"id": "C0003805", "name": "C0003805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [12, 13]}}
{"token": ["Electrophoretically", "detected", "genetic", "polymorphism", "human", "MHC", "class", "III", "genes", "C1824728#ent", "<e1>", "Bf", ")", "and", "complement", "C4A", "C1413000#ent", "<e2>", ",", "was", "studied", "in", "the", "Finnish", "population"], "h": {"id": "C1824728", "name": "C1824728#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413000", "name": "C1413000#ent", "pos": [16, 17]}}
{"token": ["Cyclosporin-induced", "hypertension", ",", "C0020473#ent", "<e1>", ",", "hyperkalaemia", "and", "C0740394#ent", "<e2>", "are", "generally", "responsive", "to", "appropriate", "dietary", "restrictions", "pharmacological", "therapies"], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0740394", "name": "C0740394#ent", "pos": [8, 9]}}
{"token": ["Disturbances", "of", "metabolism", ",", "such", "as", "C0020473#ent", "<e1>", ",", "obesity", "or", "arterial", "hypertension", "are", "often", "associated", "with", "C0740394#ent", "<e2>", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0740394", "name": "C0740394#ent", "pos": [17, 18]}}
{"token": ["We", "report", "two", "patients", "with", "C0020473#ent", "<e1>", "in", "association", "with", "C0740394#ent", "<e2>", "in", "whom", "long-term", "fenofibrate", "therapy", "associated", "with", "sustained", "reduction", "in", "serum", "urate", "lipid", "levels", "together", "with", "remission", "from", "recurrent", "attacks", "acute", "gout"], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0740394", "name": "C0740394#ent", "pos": [10, 11]}}
{"token": ["Corticosterone", "(", "C1413627#ent", "<e1>", ")", ",", "the", "glucocorticoid", "(", "C1367452#ent", "<e2>", ")", "effector", "hormone", "of", "the", "HPA", "axis", "in", "rats", ",", "inhibits", "both", "proinflammatory", "cytokine", "production/release", "activity", "of", "the", "HPA", "axis", "itself", "."], "h": {"id": "C1413627", "name": "C1413627#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [9, 10]}}
{"token": ["In", "49", "untreated", "C1428728#ent", "<e1>", "subjects", ",", "there", "was", "a", "linear", "relationship", "glycosylated", "hemoglobin", "C0000503#ent", "<e2>", ")", "and", "triglyceride", "(", "r", "=", "0.35", ",", "P", "less", "than", "0.02", ")", "."], "h": {"id": "C1428728", "name": "C1428728#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000503", "name": "C0000503#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "test", "the", "hypothesis", "that", "C0030304#ent", "<e1>", "and", "bile", "duct", "obstruction", "exacerbates", "C0013604#ent", "<e2>", "induced", "by", "supramaximal", "secretory", "stimulation", "caerulein", "."], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [19, 20]}}
{"token": ["Current", "topics", "for", "occupational", "lung", "diseases", "asbestosis", ",", "C0006542#ent", "<e1>", ",", "silicosis", ",", "coal", "worker's", "pneumoconiosis", "lung", "cancer", "and", "occupational", "asthma", "C0085129#ent", "<e2>", ",", "and", "for", "pathophysiology", "of", "airway", "hyperreactiveness", "pulmonary", "edema", "discussed", "."], "h": {"id": "C0006542", "name": "C0006542#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085129", "name": "C0085129#ent", "pos": [21, 22]}}
{"token": ["Attempts", "were", "made", "to", "determine", "if", ",", "in", "the", "mild", "stage", "of", "C0006542#ent", "<e1>", ",", "there", "are", "changes", "located", "to", "small", "airways", "if", "C0085129#ent", "<e2>", "increased", "."], "h": {"id": "C0006542", "name": "C0006542#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085129", "name": "C0085129#ent", "pos": [23, 24]}}
{"token": ["The", "principal", "components", "the", "sage", "oils", "1,8-cineole", ",", "camphor", ",", "alpha-thujone", ",", "C0053509#ent", "<e1>", ",", "borneol", ",", "and", "C2975658#ent", "<e2>", "."], "h": {"id": "C0053509", "name": "C0053509#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2975658", "name": "C2975658#ent", "pos": [18, 19]}}
{"token": ["Intravenous", "cyclophosphamide", "C0360556#ent", "<e1>", "is", "a", "useful", "early", "treatment", "C0240903#ent", "<e2>"], "h": {"id": "C0360556", "name": "C0360556#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0240903", "name": "C0240903#ent", "pos": [9, 10]}}
{"token": ["Activation", "of", "the", "vATPase", "may", "be", "central", "to", "the", "pathologic", "activation", "C0030940#ent", "<e1>", "in", "the", "acinar", "cell", "may", "also", "modulate", "the", "C0162830#ent", "<e2>", "effects", "of", "alcohols", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162830", "name": "C0162830#ent", "pos": [21, 22]}}
{"token": ["In", "HBMEC", ",", "immunocytochemistry", "revealed", "the", "presence", "of", "the", "membrane-bound", "endothelial", "protein", "C", "receptor", "C3889715#ent", "<e1>", ")", "whereas", "the", "mineralocorticoid", "receptor", "C1417835#ent", "<e2>", ")", "was", "present", "as", "a", "nucleo-cytoplasmic", "."], "h": {"id": "C3889715", "name": "C3889715#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417835", "name": "C1417835#ent", "pos": [21, 22]}}
{"token": ["The", "E4", "ORF3", "protein", "coimmunoprecipitates", "with", "the", "PML", "protein", "yet", "E4", "C1706342#ent", "<e1>", "still", "forms", "tracks", "in", "cells", "that", "lack", "C1705330#ent", "<e2>", "."], "h": {"id": "C1706342", "name": "C1706342#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705330", "name": "C1705330#ent", "pos": [20, 21]}}
{"token": ["Significant", "drops", "in", "serum", "bilirubin", "levels", "noted", "following", "expression", "of", "HUG", "C3811113#ent", "<e1>", "but", "not", "C0005220#ent", "<e2>", "."], "h": {"id": "C3811113", "name": "C3811113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [15, 16]}}
{"token": ["C1425387#ent", "<e1>", "a", "domain", "structure", "to", "this", "C1517488#ent", "<e2>", "yet", "demonstrates", "novel", "differences", "in", "its", "regulation", "and", "pattern", "of", "expression", "."], "h": {"id": "C1425387", "name": "C1425387#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [7, 8]}}
{"token": ["When", "C1420062#ent", "<e1>", "NTR-enriched", "cells", "from", "ONR", "and", "C1413269#ent", "<e2>", "cultures", "are", "compared", "directly", ",", "tissue", "source-related", "differences", "are", "no", "longer", "observed", "."], "h": {"id": "C1420062", "name": "C1420062#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413269", "name": "C1413269#ent", "pos": [8, 9]}}
{"token": ["C0028116#ent", "<e1>", "is", "a", "C0012315#ent", "<e2>", "calcium", "entry", "blocker", "that", "inhibits", "contraction", "of", "vascular", "smooth", "muscle", "a", "potency", "that", "is", "2", "-", "3", "times", "greater", "than", "its", "impact", "on", "myocardial", "contractility"], "h": {"id": "C0028116", "name": "C0028116#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [4, 5]}}
{"token": ["The", "inducibility", "of", "RNAi", "from", "this", "system", "may", "be", "useful", "in", "helping", "to", "identify", "the", "functions", "of", "genes", "which", "when", "C0669365#ent", "<e1>", "silenced", "give", "embryo", "lethality", "C2936489#ent", "<e2>", "phenotypes", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2936489", "name": "C2936489#ent", "pos": [26, 27]}}
{"token": ["Similar", "to", "prolactin", "induction", "C0080298#ent", "<e1>", "in", "tyrosine", "phosphorylation", "DNA", "binding", "both", "STAT5A", "and", "C1335876#ent", "<e2>", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1335876", "name": "C1335876#ent", "pos": [14, 15]}}
{"token": ["The", "increase", "of", "C1565860#ent", "<e1>", "mRNA", "levels", "was", "counteracted", "by", "C0005304#ent", "<e2>", "and", "taurine", "and", ",", "to", "a", "lesser", "extent", ",", "by", "myo-inositol", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005304", "name": "C0005304#ent", "pos": [10, 11]}}
{"token": ["We", "suggest", "that", "these", "differences", "in", "the", "ability", "of", "C1421511#ent", "<e1>", "to", "induce", "or", "repress", "GLT", "and", "C1420121#ent", "<e2>", "are", "due", "to", "differences", "in", "C1421511#ent", "<e1>", "dosages", "or", "Wnt-1-induced", "signaling", "pathways", "these", "cells", "."], "h": {"id": "C1421511", "name": "C1421511#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420121", "name": "C1420121#ent", "pos": [17, 18]}}
{"token": ["This", "report", "emphasizes", "the", "concurrent", "existence", "of", "mesangial", "proliferative", "glomerulonephritis", "C0031069#ent", "<e1>", "in", "the", "absence", "of", "C0268382#ent", "<e2>"], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0268382", "name": "C0268382#ent", "pos": [16, 17]}}
{"token": ["Altered", "transforming", "growth", "factor-beta", "C1366557#ent", "<e1>", ")", "expression", "may", "contribute", "to", "C0021390#ent", "<e2>", "modulate", "epithelial", "cell", "restitution", "."], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [11, 12]}}
{"token": ["INDO-PA", ",", "which", "is", "highly", "selective", "for", "COX-2", "in", "vitro", "reduced", "C1420619#ent", "<e1>", "production", "by", "61", "%", "in", "vivo", "indicating", "partial", "inhibition", "of", "C1415652#ent", "<e2>", "in", "vivo"], "h": {"id": "C1420619", "name": "C1420619#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [23, 24]}}
{"token": ["Murine", "experimental", "models", "C0022672#ent", "<e1>", "led", "to", "the", "identification", "of", "several", "factors", "involved", "in", "C0022658#ent", "<e2>", "progression", "."], "h": {"id": "C0022672", "name": "C0022672#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [14, 15]}}
{"token": ["These", "results", "indicate", "a", "possible", "influence", "of", "dietary", "n-3", "PUFAs", "on", "the", "C0032285#ent", "<e1>", "horses", "with", "C1412430#ent", "<e2>", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412430", "name": "C1412430#ent", "pos": [16, 17]}}
{"token": ["The", "present", "investigation", "addresses", "the", "mode", "of", "inhibition", "of", "the", "camel", "retinal", "acetylcholinesterase", "AChE", ")", "activity", "by", "C0016972#ent", "<e1>", "which", "is", "known", "to", "be", "a", "specific", "non-depolarizing", "neuromuscular", "blocking", "agent", "C0242897#ent", "<e2>"], "h": {"id": "C0016972", "name": "C0016972#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0242897", "name": "C0242897#ent", "pos": [30, 31]}}
{"token": ["The", "amplitude", "of", "Ca(2+)", "mobilization", "in", "individual", "cells", "C1335279#ent", "<e1>", "or", "SL-LI", "was", "increased", "significantly", "following", "exposure", "of", "cells", "to", "C1412228#ent", "<e2>", "."], "h": {"id": "C1335279", "name": "C1335279#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [20, 21]}}
{"token": ["Two", "novel", "C0030956#ent", "<e1>", ",", "pedibin", "and", "C0763790#ent", "<e2>", ",", "that", "are", "closely", "related", "to", "one", "another", "have", "been", "isolated", "from", "Hydra", "vulgaris", "Hydra", "magnipapillata"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0763790", "name": "C0763790#ent", "pos": [7, 8]}}
{"token": ["C1096184#ent", "<e1>", "infection", "should", "be", "considered", "in", "dogs", "showing", "signs", "of", "C0014038#ent", "<e2>", "when", "and", "where", "C1096184#ent", "<e1>", "and", "mosquito", "vectors", "."], "h": {"id": "C1096184", "name": "C1096184#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [11, 12]}}
{"token": ["The", "reductive", "activity", "also", "observed", "using", "other", "C0020306#ent", "<e1>", "such", "as", "methylhydroquinone", ",", "2,5-dimethylhydroquinone", ",", "and", "C0618416#ent", "<e2>", "."], "h": {"id": "C0020306", "name": "C0020306#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0618416", "name": "C0618416#ent", "pos": [16, 17]}}
{"token": ["Two", "C0003872#ent", "<e1>", "patients", "with", "hypertriglycemia", "were", "treated", "with", "mg", "of", "oral", "C2347008#ent", "<e2>", "daily", "."], "h": {"id": "C0003872", "name": "C0003872#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2347008", "name": "C2347008#ent", "pos": [12, 13]}}
{"token": ["A", "22-year-old", "man", "with", "recurrent", "oral", "and", "C0151281#ent", "<e1>", "erythema", "nodosum", "folliculitis", ",", "positive", "pathergic", "reaction", ",", "uveitis", ",", "C0038833#ent", "<e2>", "and", "generalized", "lymphadenopathy", "the", "diagnostic", "criteria", "Beh\u00e7et's", "disease"], "h": {"id": "C0151281", "name": "C0151281#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038833", "name": "C0038833#ent", "pos": [19, 20]}}
{"token": ["HSV-mediated", "gene", "transfer", "may", "allow", "the", "therapeutic", "potential", "of", "these", "C0030956#ent", "<e1>", "for", "the", "treatment", "of", "C0042075#ent", "<e2>", "be", "realised", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [16, 17]}}
{"token": ["The", "conjugation", "of", "NEDD8", "to", "target", "proteins", "is", "initiated", "by", "the", "C1452523#ent", "<e1>", "enzyme", "composed", "of", "APP-BP1", "and", "C1421269#ent", "<e2>", "."], "h": {"id": "C1452523", "name": "C1452523#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421269", "name": "C1421269#ent", "pos": [18, 19]}}
{"token": ["Several", "markers", "of", "lymphatic", "endothelial", "cells", "expressed", "in", "both", "mouse", "and", "human", ",", "like", "C1335205#ent", "<e1>", ",", "Prox1", ",", "podoplanin", ",", "and", "C1422841#ent", "<e2>", "."], "h": {"id": "C1335205", "name": "C1335205#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1422841", "name": "C1422841#ent", "pos": [22, 23]}}
{"token": ["VEGF-D", "expressing", "tumors", "exhibited", "increased", "microvessel", "density", "and", "increased", "abundance", "of", "peri-", "and", "intratumoral", "lymphatics", "as", "assessed", "by", "immunostaining", "for", "C1335205#ent", "<e1>", "and", "for", "C1422841#ent", "<e2>", "and/or", "podoplanin", ",", "respectively", "."], "h": {"id": "C1335205", "name": "C1335205#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1422841", "name": "C1422841#ent", "pos": [24, 25]}}
{"token": ["Transcranial", "magnetic", "stimulation", "used", "to", "probe", "the", "acute", "effect", "a", "single", "oral", "dose", "various", "dopaminergic", "(", "levodopa", ",", "C0036579#ent", "<e1>", ",", "bromocriptine", ")", "and", "antidopaminergic", "drugs", "C0038803#ent", "<e2>", ",", "haloperidol", ")", "on", "motor", "cortex", "excitability", "in", "healthy", "volunteers"], "h": {"id": "C0036579", "name": "C0036579#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0038803", "name": "C0038803#ent", "pos": [26, 27]}}
{"token": ["The", "C1704321#ent", "<e1>", "commonly", "caused", "by", "various", "C0017658#ent", "<e2>", ",", "i.e.", "minimal", "change", "C1704321#ent", "<e1>", "focal", "segmental", "glomerulosclerosis", "membranous", "nephropathy"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [1, 2]}}
{"token": ["Viruses", ",", "including", "human", "C1959635#ent", "<e1>", "may", "trigger", "bouts", "of", "systemic", "lupus", "erythematosus", "C1516876#ent", "<e2>", "susceptible", "individuals", "."], "h": {"id": "C1959635", "name": "C1959635#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [13, 14]}}
{"token": ["Discoid", "lupus", "erythematosus", "C0024138#ent", "<e1>", ")", "is", "a", "C0008679#ent", "<e2>", "photoexposed", "areas", "and", "has", "also", "been", "associated", "with", "cigarette", "smoking"], "h": {"id": "C0024138", "name": "C0024138#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [8, 9]}}
{"token": ["Thus", ",", "the", "formation", "of", "asparaginase", "is", "regulated", "in", "parallel", "with", "that", "of", "other", "enzymes", "capable", "of", "supplying", "the", "cell", "with", "ammonia", "or", "C0017789#ent", "<e1>", ",", "such", "as", "C1415465#ent", "<e2>", "and", "proline", "oxidase"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1415465", "name": "C1415465#ent", "pos": [28, 29]}}
{"token": ["Thus", ",", "despite", "normal", "expression", "and", "tyrosine", "phosphorylation", "C4084755#ent", "<e1>", "does", "not", "associate", "with", "C0812303#ent", "<e2>", "in", "Jurkat", "cells", "in", "other", "human", "T", "cell", "lines"], "h": {"id": "C4084755", "name": "C4084755#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812303", "name": "C0812303#ent", "pos": [14, 15]}}
{"token": ["A", "female", "patient", "had", "permanent", "C0026837#ent", "<e1>", "to", "the", "\"", "C0085292#ent", "<e2>", ",", "together", "with", "axial", "myoclonus", "by", "stretch", "reflexes", "by", "supramaximal", "stimulation", "of", "the", "supraorbital", "nerve"], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0085292", "name": "C0085292#ent", "pos": [10, 11]}}
{"token": ["In", "chromatin", "immunoprecipitation", "assays", "NIH", "3T3", "cells", "C1514550#ent", "<e1>", "recruitment", "of", "C1333336#ent", "<e2>", "to", "the", "somatostatin", "promoter", "stimulated", "acetylation", "of", "histone", "H4"], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333336", "name": "C1333336#ent", "pos": [11, 12]}}
{"token": ["Administration", "of", "C1512412#ent", "<e1>", "kumari", "asav", ",", "kumari", "kalp", ",", "C0052394#ent", "<e2>", "and", "tamra", "bhasma", ")", "concomitant", "with", "CCl4", "counteracted", "the", "action", "of", "CCl4", "on", "lipolytic", "enzymes", "hepatoprotection", "."], "h": {"id": "C1512412", "name": "C1512412#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0052394", "name": "C0052394#ent", "pos": [10, 11]}}
{"token": ["Performance", "along", "both", "control", "dimensions", "impaired", "in", "the", "mild", "stages", "C0242422#ent", "<e1>", ",", "even", "before", "the", "appearance", "of", "C0426980#ent", "<e2>"], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0426980", "name": "C0426980#ent", "pos": [18, 19]}}
{"token": ["Arrb2", ",", "Stx12", ",", "Aqp6", ",", "C1420556#ent", "<e1>", ",", "Ddc", ",", "and", "C3814452#ent", "<e2>", "expression", "levels", "were", "changed", "only", "in", "the", "PCB-exposed", "SD", "rats", "."], "h": {"id": "C1420556", "name": "C1420556#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3814452", "name": "C3814452#ent", "pos": [12, 13]}}
{"token": ["It", "has", "a", "relatively", "low", "affinity", "for", "the", "C0027203#ent", "<e1>", ",", "though", "it", "is", "superior", "to", "C0144544#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0144544", "name": "C0144544#ent", "pos": [16, 17]}}
{"token": ["Acetate", "showed", "promotive", "effect", "C0027203#ent", "<e1>", "adsorption", "at", "lower", "anion", "concentrations", "whereas", "oxalate", ",", "C0144544#ent", "<e2>", "and", "phosphate", "compete", "effectively", "with", "C0027203#ent", "<e1>", "in", "a", "broad", "range", "of", "anion", "concentration", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0144544", "name": "C0144544#ent", "pos": [14, 15]}}
{"token": ["Two", "of", "the", "novel", "genes", ",", "mesdc1", "and", "C3273811#ent", "<e1>", ",", "are", "located", "within", "the", "C1422033#ent", "<e2>", "critical", "region", "defined", "by", "BAC", "transgenic", "rescue", "."], "h": {"id": "C3273811", "name": "C3273811#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1422033", "name": "C1422033#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "neither", "C0055461#ent", "<e1>", "nor", "bafilomycin", "A1", "inhibit", "total", "protein", "synthesis", "synthesis", "of", "C0013765#ent", "<e2>", "."], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [15, 16]}}
{"token": ["In", "peripheral", "blood", "mononuclear", "cells", "PBMCs", ")", ",", "activation", "by", "PHA", ",", "PMA", "and", "alpha-CD3", "increased", "C0019643#ent", "<e1>", "mRNA", "but", "no", "effect", "seen", "with", "IFN-gamma", ",", "C0175697#ent", "<e2>", ",", "or", "IL-4", "."], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [26, 27]}}
{"token": ["Using", "a", "two-hybrid", "screen", "gene", "products", "interact", "with", "Kss1", ",", "two", "C1512488#ent", "<e1>", "and", "previously", "uncharacterized", "loci", "(", "C1419275#ent", "<e2>", "and", "DIG2", ",", "for", "down-regulator", "of", "invasive", "growth", "were", "identified", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419275", "name": "C1419275#ent", "pos": [18, 19]}}
{"token": ["They", "are", "transcription", "factors", "activate", "C0017337#ent", "<e1>", "as", "part", "of", "a", "heterodimeric", "complex", "with", "the", "C0919516#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919516", "name": "C0919516#ent", "pos": [15, 16]}}
{"token": ["C0010587#ent", "<e1>", "provides", "a", "definitive", "non-deleterious", "mode", "of", "inhibiting", "C1705819#ent", "<e2>", "for", "immunoperoxidase", "staining", "delicate", "antigens"], "h": {"id": "C0010587", "name": "C0010587#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705819", "name": "C1705819#ent", "pos": [9, 10]}}
{"token": ["To", "date", ",", "only", "7", "cases", "of", "ventriculoperitoneal", "(", "VP", ")", "shunting", "for", "the", "treatment", "of", "C0033845#ent", "<e1>", "patients", "with", "C0085436#ent", "<e2>", "been", "reported", "."], "h": {"id": "C0033845", "name": "C0033845#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0085436", "name": "C0085436#ent", "pos": [20, 21]}}
{"token": ["C0054670#ent", "<e1>", "produced", "mild", "lower", "C0000729#ent", "<e2>", "most", "patients", "and", "severe", "pain", "in", "three", "patients", "who", "received", "50", "or", "100", "micrograms", "intravenously", "or", "70", "micrograms", "intramuscularly", "."], "h": {"id": "C0054670", "name": "C0054670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000729", "name": "C0000729#ent", "pos": [5, 6]}}
{"token": ["We", "have", "demonstrated", "the", "presence", "of", "a", "GTPase-activating", "protein", "C2984553#ent", "<e1>", ")", "for", "the", "C1335596#ent", "<e2>", "the", "cytosolic", "fraction", "brain", "and", "testis", "."], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335596", "name": "C1335596#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "our", "results", "indicate", "that", "brain", "histamine", "synthesis", "is", "subjected", "to", "regulation", "by", "phosphatases", "PP2A", "C1826646#ent", "<e1>", ",", "and", "perhaps", "also", "PP2B", "as", "well", "as", "by", "C0030940#ent", "<e2>"], "h": {"id": "C1826646", "name": "C1826646#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [28, 29]}}
{"token": ["The", "moderate", "rise", "in", "[3H]lysoplasmenylethanolamine", "formation", "with", "U46619", "as", "the", "C2987634#ent", "<e1>", "was", "only", "slightly", "affected", "by", "C0006536#ent", "<e2>", "and", "blocked", "by", "GR32191B", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006536", "name": "C0006536#ent", "pos": [17, 18]}}
{"token": ["C0950386#ent", "<e1>", "was", "highly", "effective", "as", "a", "C0032177#ent", "<e2>", "monkeys", "after", "oral", "administration"], "h": {"id": "C0950386", "name": "C0950386#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032177", "name": "C0032177#ent", "pos": [7, 8]}}
{"token": ["C3273301#ent", "<e1>", "directly", "interacts", "with", "C1705526#ent", "<e2>", ",", "thereby", "preventing", "MDM2-mediated", "ubiquitination", "and", "degradation", "of", "C1705526#ent", "<e2>", "."], "h": {"id": "C3273301", "name": "C3273301#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [5, 6]}}
{"token": ["Platelets", "from", "a", "patient", "with", "an", "acquired", "C0851563#ent", "<e1>", "a", "severely", "impaired", "response", "to", "C0009325#ent", "<e2>", ",", "whereas", "platelet", "aggregation", "other", "agonists", "and", "coagulations", "tests", "normal", "."], "h": {"id": "C0851563", "name": "C0851563#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "there", "are", "very", "few", "\"", "user", "reports", "of", "effects", "when", "C0044180#ent", "<e1>", "is", "taken", "alone", "or", "in", "combination", "with", "C3538848#ent", "<e2>", "[", "1-benzylpiperazine", "]", "."], "h": {"id": "C0044180", "name": "C0044180#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3538848", "name": "C3538848#ent", "pos": [22, 23]}}
{"token": ["The", "C0812329#ent", "<e1>", "been", "recognized", "for", "their", "roles", "in", "the", "regulation", "of", "C0250414#ent", "<e2>", "Ca(2+)", "mobilization", "downstream", "from", "antigen", "receptors", "lymphocytes", "."], "h": {"id": "C0812329", "name": "C0812329#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0250414", "name": "C0250414#ent", "pos": [12, 13]}}
{"token": ["In", "spite", "of", "lower", "consumption", "of", "C0728960#ent", "<e1>", ",", "the", "symptoms", "appeared", "milder", "during", "C0025859#ent", "<e2>", "than", "during", "placebo", "."], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [14, 15]}}
{"token": ["The", "structural", "and", "functional", "homology", "of", "the", "KLP61F", ",", "bimC", ",", "cut7", ",", "and", "Eg5", "C3541291#ent", "<e1>", "the", "existence", "of", "a", "conserved", "family", "of", "C1416697#ent", "<e2>", "for", "spindle", "pole", "separation", "mitotic", "spindle", "dynamics"], "h": {"id": "C3541291", "name": "C3541291#ent", "pos": [15, 16]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416697", "name": "C1416697#ent", "pos": [24, 25]}}
{"token": ["Ligand", "binding", "C1539098#ent", "<e1>", "was", "inhibited", "by", "EGTA", "but", "not", "by", "C0024727#ent", "<e2>", ",", "suggesting", "that", "C1539098#ent", "<e1>", "unlike", "DC-SIGN/R", "does", "not", "recognize", "high-mannose", "glycans", "on", "viral", "GPs"], "h": {"id": "C0024727", "name": "C0024727#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1539098", "name": "C1539098#ent", "pos": [2, 3]}}
{"token": ["Nephrotoxicity", ",", "in", "the", "form", "of", "transient", "proteinuria", "C0554309#ent", "<e1>", ",", "abnormalities", "of", "tubular", "function", "and", "C0022660#ent", "<e2>", "is", "the", "major", "toxic", "condition", "administration", "of", "streptozotocin", "."], "h": {"id": "C0554309", "name": "C0554309#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [16, 17]}}
{"token": ["Local", "pretreatment", "with", "the", "GABAA", "receptor", "agonist", "C1337104#ent", "<e1>", "(", "2", "nmol", ")", "blocked", "the", "effect", "of", "C0022471#ent", "<e2>"], "h": {"id": "C1337104", "name": "C1337104#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [17, 18]}}
{"token": ["We", "now", "report", "that", "the", "TLR2", "and", "TLR5", "C0243192#ent", "<e1>", "--", "Pam3Cys", "and", "bacterial", "flagellin", "have", "similar", "effects", "on", "C3539694#ent", "<e2>", "surface", "expression", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3539694", "name": "C3539694#ent", "pos": [19, 20]}}
{"token": ["Up-regulation", "of", "WNT5A", "and", "C1424137#ent", "<e1>", "in", "several", "types", "of", "human", "cancer", "expressing", "C1414888#ent", "<e2>", "might", "lead", "to", "more", "malignant", "phenotype", "through", "activation", "of", "the", "beta-catenin", "-", "TCF", "pathway", "."], "h": {"id": "C1424137", "name": "C1424137#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414888", "name": "C1414888#ent", "pos": [13, 14]}}
{"token": ["We", "compared", "mRNA", "expressions", "of", "C1415652#ent", "<e1>", "and", "COX-2", "in", "C1705969#ent", "<e2>", "vs.", "non-CD", "cells", "isolated", "from", "aquaporin", "2-green", "fluorescent", "protein", "transgenic", "mice"], "h": {"id": "C1415652", "name": "C1415652#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "coadministration", "of", "the", "H2-receptor", "antagonist", "C0008783#ent", "<e1>", "on", "the", "pharmacokinetics", "and", "pharmacodynamics", "of", "the", "H1-receptor", "antagonists", "C0020404#ent", "<e2>", "and", "cetirizine", "were", "studied", "in", "rabbits", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020404", "name": "C0020404#ent", "pos": [19, 20]}}
{"token": ["C1432368#ent", "<e1>", "a", "burgeoning", "family", "of", "C3541394#ent", "<e2>", ",", "some", "of", "which", ",", "the", "MKPs", ",", "are", "implicated", "in", "the", "regulation", "of", "mitogen-activated", "protein", "MAP", ")", "kinases", "."], "h": {"id": "C1432368", "name": "C1432368#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [6, 7]}}
{"token": ["These", "include", "both", "nuclear", "(", "C1432368#ent", "<e1>", ")", "and", "cytoplasmic", "(", "DUSP6", ")", "C3541394#ent", "<e2>", "."], "h": {"id": "C1432368", "name": "C1432368#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["None", "of", "the", "three", "C0991617#ent", "<e1>", "affected", "the", "charge", "modification", "C0072034#ent", "<e2>", "Mr", "53,000", ")", "within", "the", "Golgi", "apparatus"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072034", "name": "C0072034#ent", "pos": [10, 11]}}
{"token": ["The", "C0036457#ent", "<e1>", "prion", "protein", "PrP(Sc", ")", ",", "as", "well", "as", "its", "peptide", "fragment", "C1419980#ent", "<e2>", "-", "126", ",", "are", "toxic", "on", "neuronal", "cells", "resulting", "in", "cell", "death", "an", "apoptotic", ",", "rather", "than", "necrotic", "mechanism"], "h": {"id": "C0036457", "name": "C0036457#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419980", "name": "C1419980#ent", "pos": [14, 15]}}
{"token": ["The", "leptin-induced", "changes", "in", "arachidonic", "acid", "release", "and", "PGE(2)", "were", "blocked", "by", "ERK", "inhibitor", ",", "C0298346#ent", "<e1>", ",", "but", "not", "by", "C1705590#ent", "<e2>", "wortmannin", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [21, 22]}}
{"token": ["Depletion", "of", "nutrients", "is", "known", "to", "cause", "adverse", "effects", "as", "C0007758#ent", "<e1>", ",", "nystagmus", ",", "lethargy", ",", "slurred", "speech", "C0236811#ent", "<e2>"], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0236811", "name": "C0236811#ent", "pos": [19, 20]}}
{"token": ["C0030946#ent", "<e1>", "treatment", "of", "erythrocytes", "infected", "with", "P.", "berghei", "CR", "(", "C0008269#ent", "<e2>", "resistant", ")", "produced", "a", "dramatic", "transformation", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [11, 12]}}
{"token": ["Concomitant", "treatment", "with", "glycosaminoglycan-peptide", "complex", "GP-C", "=", "C0073706#ent", "<e1>", ")", "overcame", "the", "negative", "effect", "of", "C0011777#ent", "<e2>", "."], "h": {"id": "C0073706", "name": "C0073706#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [15, 16]}}
{"token": ["SEM", "revealed", "the", "surfaces", "of", "isolated", ",", "HeLa", "cell", "chromosomes", "possess", "a", "knobby", "substructure", "with", "chromosomes", "prepared", "for", "C0014921#ent", "<e1>", "in", "buffers", "containing", "0.5", "-", "1.5", "mM", "C1417500#ent", "<e2>", "+", "."], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [27, 28]}}
{"token": ["However", ",", "C1413737#ent", "<e1>", "showed", "a", "substantial", "increase", "in", "indoor", "C3539565#ent", "<e2>", ",", "PN", ",", "and", "PM2.5", "between", "6:00", "and", "9:00", "a.m.", ",", "probably", "from", "cooking", "."], "h": {"id": "C1413737", "name": "C1413737#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539565", "name": "C3539565#ent", "pos": [10, 11]}}
{"token": ["Patients", "receiving", "transdermal", "scopolamine", "were", "compared", "with", "patients", "receiving", "diphenhydramine", ",", "C0025039#ent", "<e1>", ",", "prochlorperazine", ",", "and", "C0033405#ent", "<e2>", "."], "h": {"id": "C0025039", "name": "C0025039#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033405", "name": "C0033405#ent", "pos": [17, 18]}}
{"token": ["The", "protective", "and", "adverse", "effect", "potentials", "of", "C0377265#ent", "<e1>", "(", "(S)-alpha-ethyl-2-oxo-pyrrolidine", "acetamide", "in", "rodent", "models", "seizures", "and", "C0014544#ent", "<e2>", "were", "compared", "with", "the", "profile", "of", "several", "currently", "prescribed", "and", "newly", "developed", "antiepileptic", "drugs"], "h": {"id": "C0377265", "name": "C0377265#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [17, 18]}}
{"token": ["This", "study", "shows", "that", "a", "considerable", "amount", "of", "aspirin", "is", "used", "C0013231#ent", "<e1>", "in", "those", "with", "C0007820#ent", "<e2>", "."], "h": {"id": "C0013231", "name": "C0013231#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [16, 17]}}
{"token": ["C1846980#ent", "<e1>", "a", "rare", "C1848862#ent", "<e2>", "of", "retinopathy", "and", "nephronophthisis", "."], "h": {"id": "C1846980", "name": "C1846980#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}}
{"token": ["Thus", "this", "C0002085#ent", "<e1>", "variant", "of", "rat", "alpha", "6", "subunit", "assemble", "with", "other", "C0599220#ent", "<e2>", "to", "form", "a", "functional", "GABAA", "receptor", "channel", "with", "similar", "properties", "to", "the", "original", "C0002085#ent", "<e1>", "form", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [13, 14]}}
{"token": ["We", "characterized", "new", "mutant", "C0002085#ent", "<e1>", "of", "the", "genes", "encoding", "the", "C0599220#ent", "<e2>", "this", "complex", ",", "smc2", "-", "8", "and", "smc4", "-", "1", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [11, 12]}}
{"token": ["A", "total", "of", "15", "patients", "with", "C0021400#ent", "<e1>", "like", "illness", "from", "one", "residential", "area", "the", "nursing", "home", "administered", "C0035629#ent", "<e2>", ",", "100", "mg", "per", "day", "for", "five", "days", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0035629", "name": "C0035629#ent", "pos": [18, 19]}}
{"token": ["At", "present", ",", "three", "licensed", "C0021400#ent", "<e1>", "available", "in", "Japan", ":", "C0035629#ent", "<e2>", ",", "zanamivir", ",", "and", "oseltamivir", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0035629", "name": "C0035629#ent", "pos": [11, 12]}}
{"token": ["In", "the", "non", "zinc-deficient", "group", "of", "pregnant", "females", "gamma-linolenic", "acid", "supplementation", "had", "no", "effect", "fatty", "acid", "synthetase", "C0065017#ent", "<e1>", "activities", "but", "significantly", "increased", "C0020374#ent", "<e2>", "."], "h": {"id": "C0065017", "name": "C0065017#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020374", "name": "C0020374#ent", "pos": [23, 24]}}
{"token": ["The", "two", "most", "frequent", "etiologies", "were", "C0042029#ent", "<e1>", "metabolic", "disorders", "hypercalciuria", "states", ",", "distal", "renal", "tubular", "acidosis", "C0010691#ent", "<e2>", ")", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [17, 18]}}
{"token": ["C0006111#ent", "<e1>", "associated", "with", "increased", "intracranial", "pressure", "cause", "increased", "cerebrospinal", "fluid", "vasopressin", "concentrations", ",", "whereas", "C1456654#ent", "<e2>", "associated", "with", "low", "concentrations", "."], "h": {"id": "C0006111", "name": "C0006111#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C1456654", "name": "C1456654#ent", "pos": [15, 16]}}
{"token": ["C0062212#ent", "<e1>", "decreased", "the", "faecal", "content", "of", "C0072497#ent", "<e2>", "from", "557", "+", "/-", "91", "to", "118", "+", "/-", "32", "(", "mean", "+", "/-", "s.e", "."], "h": {"id": "C0062212", "name": "C0062212#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072497", "name": "C0072497#ent", "pos": [7, 8]}}
{"token": ["These", "results", "demonstrate", "a", "novel", "interaction", "of", "C0029408#ent", "<e1>", "with", "the", "C1419090#ent", "<e2>", "and", "suggest", "a", "role", "for", "C0029408#ent", "<e1>", "in", "modulating", "Stat1-mediated", "signaling", "to", "an", "immediate", "early", "gene", "promoter"], "h": {"id": "C1419090", "name": "C1419090#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [7, 8]}}
{"token": ["The", "tyrosine", "kinase", "activity", "the", "EGFR", "was", "a", "prerequisite", "for", "this", "stimulation", ",", "since", "treatment", "of", "cells", "with", "a", "C0033671#ent", "<e1>", "this", "receptor", ",", "C0528985#ent", "<e2>", ",", "completely", "abrogated", "shedding", "."], "h": {"id": "C0033671", "name": "C0033671#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0528985", "name": "C0528985#ent", "pos": [24, 25]}}
{"token": ["Tropisetron", "is", "a", "C0360055#ent", "<e1>", "suppresses", "nausea", "and", "vomiting", "induced", "by", "C1516468#ent", "<e2>"], "h": {"id": "C0360055", "name": "C0360055#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516468", "name": "C1516468#ent", "pos": [11, 12]}}
{"token": ["The", "C1436406#ent", "<e1>", "EC", "3.4.22.17", ")", "was", "identified", "as", "the", "C0027203#ent", "<e2>", "which", "removed", "a", "32", "kDa", "carboxyl", "portion", "from", "the", "Cx50", "molecule", "in", "mature", "lens", "fiber", "cells"], "h": {"id": "C1436406", "name": "C1436406#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}}
{"token": ["These", "results", "indicate", "that", "the", "Doppler", "technique", "here", "has", "an", "obvious", "C1121259#ent", "<e1>", "detecting", "and", "evaluating", "regurgitant", "flow", "C0018824#ent", "<e2>"], "h": {"id": "C1121259", "name": "C1121259#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [18, 19]}}
{"token": ["C0812198#ent", "<e1>", "accumulation", "in", "Arabidopsis", "mesophyll", "protoplasts", "expressing", "murine", "Bax", "cDNA", "a", "C1142644#ent", "<e2>", "in", "cytological", "characteristics", "of", "apoptosis", ",", "namely", "DNA", "fragmentation", "increased", "vacuolation", ",", "and", "loss", "of", "plasma", "membrane", "."], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [12, 13]}}
{"token": ["A", "36-year-old", "man", "developed", "recurrent", "C1306587#ent", "<e1>", "bi-", "a", "lateral", "sensorineural", "hearing", "loss", "and", "retinal", "arteriolar", "occlusions", "caused", "by", "C0155765#ent", "<e2>", "from", "a", "year", "previously", "."], "h": {"id": "C1306587", "name": "C1306587#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0155765", "name": "C0155765#ent", "pos": [19, 20]}}
{"token": ["Spectrofluorometric", "techniques", "have", "been", "employed", "to", "examine", "the", "active", "site", "the", "terminal", "C0027203#ent", "<e1>", "of", "the", "heme", "biosynthetic", "pathway", "ferrochelatase", "(", "protoheme", "ferrolyase", "C3542407#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "cellobionolactone", "inhibited", "cellobiose", "hydrolysis", "by", "the", "BGL", ",", "suggesting", "that", "this", "C0027203#ent", "<e1>", "can", "not", "cooperate", "with", "cellobiose", "dehydrogenase", "C3542407#ent", "<e2>", ")", "in", "cellulose", "degradation", "by", "P.", "chrysosporium"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [21, 22]}}
{"token": ["Thirty", "patients", "were", "entered", "into", "a", "double-blind", "trial", "a", "dimethoxynaphthalene", "derivative", "RS-43179", "gel", ")", "and", "C0016298#ent", "<e1>", "Synalar", "gel", ")", "in", "the", "treatment", "of", "C0033860#ent", "<e2>", "."], "h": {"id": "C0016298", "name": "C0016298#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [24, 25]}}
{"token": ["Several", "non-MRC", "proteins", "localized", "in", "the", "mitochondria", ",", "e.g.", "C1427590#ent", "<e1>", ",", "Bim", ",", "Bak", ",", "and", "C0376515#ent", "<e2>", ",", "are", "also", "rapidly", "up-regulated", "."], "h": {"id": "C1427590", "name": "C1427590#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [17, 18]}}
{"token": ["Functionally", ",", "however", ",", "they", "are", "comparable", "to", "nonautoreactive", "B", "cells", "in", "C1539078#ent", "<e1>", "up-regulation", "of", "activation", "and", "C2985420#ent", "<e2>", "and", "Ab-forming", "cell", "differentiation", "when", "treated", "with", "variety", "of", "stimuli", "in", "vitro"], "h": {"id": "C1539078", "name": "C1539078#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2985420", "name": "C2985420#ent", "pos": [18, 19]}}
{"token": ["Cadaveric", "aortic", "intimas", "with", "uncomplicated", "C0003850#ent", "<e1>", "were", "examined", "to", "determine", "the", "distribution", "and", "C1305923#ent", "<e2>", "of", "fibrinogen-related", "protein", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}}
{"token": ["To", "monitor", "the", "safety", "and", "efficacy", "profile", "of", "long-term", "treatment", "with", "C0700583#ent", "<e1>", ",", "nabumetone", ",", "meloxicam", "and", "celecoxib", "in", "patients", "with", "C0003873#ent", "<e2>"], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [22, 23]}}
{"token": ["We", "describe", "a", "patient", "with", "C0004943#ent", "<e1>", "experienced", "diffuse", "proliferative", "glomerulonephritis", "epithelial", "cell", "crescent", "formation", "75", "%", "of", "C0268731#ent", "<e2>", "examined", "."], "h": {"id": "C0004943", "name": "C0004943#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [18, 19]}}
{"token": ["Both", "C1334089#ent", "<e1>", "and", "hydrocortisone", "treatments", ",", "however", ",", "significantly", "increased", "C0083183#ent", "<e2>", ",", "maltase", "and", "sucrase", "activities", "and", "hydrocortisone", "significantly", "increased", "aminopeptidase", "activity", "the", "proximal", "small", "intestine", "compared", "with", "the", "control", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0083183", "name": "C0083183#ent", "pos": [11, 12]}}
{"token": ["The", "inhibition", "of", "lysosomal", "enzyme", "from", "granulocytes", "after", "zymosan", "stimulation", "was", "significantly", "less", "p", "less", "than", "0.01", ")", "in", "C0013595#ent", "<e1>", "with", "all", "concentrations", "of", "C0282210#ent", "<e2>", "tested", "."], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [25, 26]}}
{"token": ["Studies", "of", "mononuclear", "leukocytes", "patients", "with", "C0013595#ent", "<e1>", "depressed", "cyclic", "AMP", "cAMP", ")", "responses", "after", "exposure", "to", "C0282210#ent", "<e2>", ",", "histamine", ",", "and", "prostaglandin", "E1"], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [17, 18]}}
{"token": ["C0072171#ent", "<e1>", "significantly", "increased", "hippocampal", "C0008407#ent", "<e2>", "in", "basal", "forebrain-lesioned", "rats", "compared", "with", "that", "in", "vehicle-treated", "basal", "forebrain-lesioned", "rats", "."], "h": {"id": "C0072171", "name": "C0072171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008407", "name": "C0008407#ent", "pos": [5, 6]}}
{"token": ["Here", "we", "report", "that", "the", "function", "of", "C1412501#ent", "<e1>", "is", "regulated", "by", "C0108555#ent", "<e2>"], "h": {"id": "C1412501", "name": "C1412501#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0108555", "name": "C0108555#ent", "pos": [12, 13]}}
{"token": ["The", "adrenocortical", "reserve", "function", "20", "cases", "of", "paediatric", "C0008354#ent", "<e1>", "was", "studied", "by", "intravenous", "C1704793#ent", "<e2>", "tests", "."], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [14, 15]}}
{"token": ["H-7", ",", "an", "inhibitor", "of", "PKA", ",", "PKC", ",", "and", "C4084713#ent", "<e1>", ",", "partially", "inhibited", "cell", "killing", "allyl", "alcohol", "whereas", "C0109289#ent", "<e2>", "a", "nonselective", "PKC", "inhibitor", ",", "almost", "completely", "abolished", "allyl", "alcohol", "cytotoxicity", "."], "h": {"id": "C4084713", "name": "C4084713#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0109289", "name": "C0109289#ent", "pos": [20, 21]}}
{"token": ["The", "known", "genetic", "disorders", "C0268573#ent", "<e1>", "succinic", "semialdehyde", "dehydrogenase", "SSADH", ")", "deficiency", "and", "C3495554#ent", "<e2>", "."], "h": {"id": "C0268573", "name": "C0268573#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3495554", "name": "C3495554#ent", "pos": [13, 14]}}
{"token": ["Both", "C3887559#ent", "<e1>", "RANTES", "bound", "to", "intact", "C3889469#ent", "<e2>", "and", "retained", "their", "adhesive", "properties", "and", "moreover", ",", "ECM-bound", "RANTES", "and", "C3887559#ent", "<e1>", "prolonged", "the", "time", "course", "interactions", "between", "the", "CD4+", "T", "cells", "the", "C3889469#ent", "<e2>", "."], "h": {"id": "C3887559", "name": "C3887559#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889469", "name": "C3889469#ent", "pos": [7, 8]}}
{"token": ["The", "isolates", "most", "resistant", "or", "most", "sensitive", "to", "C0034283#ent", "<e1>", "were", "also", "the", "most", "resistant", "or", "most", "sensitive", "to", "C0055349#ent", "<e2>", ",", "indicating", "partial", "cross-resistance", "between", "the", "two", "drugs", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0055349", "name": "C0055349#ent", "pos": [19, 20]}}
{"token": ["Its", "enzymatic", "activity", "completely", "inhibited", "by", "C0031493#ent", "<e1>", "PMSF", ")", ",", "but", "not", "affected", "by", "C0012695#ent", "<e2>", "."], "h": {"id": "C0031493", "name": "C0031493#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [15, 16]}}
{"token": ["Using", "the", "yeast", "two-hybrid", "screening", "system", "we", "found", "that", "the", "oxygen", "dependent", "degradation", "(", "ODD", ")", "domain", "of", "C1333897#ent", "<e1>", "interacts", "with", "necdin", ",", "a", "C1426160#ent", "<e2>"], "h": {"id": "C1333897", "name": "C1333897#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1426160", "name": "C1426160#ent", "pos": [25, 26]}}
{"token": ["It", "is", "C0066282#ent", "<e1>", "MeSA", ")", ",", "an", "inactive", "derivative", "of", "the", "defense", "hormone", "C0036079#ent", "<e2>", "SA", ")", "."], "h": {"id": "C0066282", "name": "C0066282#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036079", "name": "C0036079#ent", "pos": [14, 15]}}
{"token": ["Quality", "of", "life", "C0518214#ent", "<e1>", ")", "is", "a", "central", "outcome", "measure", "caring", "for", "seriously", "C0231218#ent", "<e2>", "patients", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [14, 15]}}
{"token": ["C0010678#ent", "<e1>", "is", "the", "most", "important", "C0747256#ent", "<e2>", "the", "nervous", "system"], "h": {"id": "C0010678", "name": "C0010678#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [6, 7]}}
{"token": ["Murine", "and", "human", "C1420642#ent", "<e1>", "displayed", "a", "95.5", "%", "overall", "C2917660#ent", "<e2>", "homology", "."], "h": {"id": "C1420642", "name": "C1420642#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [10, 11]}}
{"token": ["These", "include", "qacEDelta1", ",", "which", "confers", "resistance", "to", "quaternary", "ammonium", "compounds", "often", "associated", "with", "C0003205#ent", "<e1>", ",", "along", "with", "a", "C1332809#ent", "<e2>", "expressing", "resistance", "to", "sulphonamide", "antimicrobial", "agents"], "h": {"id": "C0003205", "name": "C0003205#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332809", "name": "C1332809#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "thrombus", "formation", "blood", "from", "one", "patient", "with", "C0040015#ent", "<e1>", "two", "patients", "with", "C1264040#ent", "<e2>", "almost", "abolished", "at", "this", "blood", "flow", "."], "h": {"id": "C0040015", "name": "C0040015#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1264040", "name": "C1264040#ent", "pos": [15, 16]}}
{"token": ["Tissue", "distribution", "studies", "in", "the", "rat", "revealed", "that", "whereas", "C0036723#ent", "<e1>", "serine", "aminotransferase", "activities", "were", "largely", "confined", "to", "the", "liver", ",", "C0070942#ent", "<e2>", "serine", "hydroxymethyltransferase", "activities", "were", "more", "broadly", "distributed", "."], "h": {"id": "C0036723", "name": "C0036723#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0070942", "name": "C0070942#ent", "pos": [21, 22]}}
{"token": ["C0036723#ent", "<e1>", "EC", "4.2.1.13", ")", ",", "glycerate", "dehydrogenase", "EC", "1.1.1.29", ")", "and", "C0070942#ent", "<e2>", ":", "L-glutamate", "transaminase", "activities", "remained", "constant", "in", "livers", "from", "chicks", "fed", "all", "experimental", "diets"], "h": {"id": "C0036723", "name": "C0036723#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0070942", "name": "C0070942#ent", "pos": [12, 13]}}
{"token": ["From", "this", "study", ",", "it", "is", "concluded", "that", "in", "invasive", "ductal", "carcinoma", "the", "breast", ",", "the", "large", "C2984879#ent", "<e1>", "and", "MT", "overexpression", "are", "correlated", "with", "histologic", "grades", "C1414461#ent", "<e2>", "negativity", "."], "h": {"id": "C2984879", "name": "C2984879#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414461", "name": "C1414461#ent", "pos": [27, 28]}}
{"token": ["High-performance", "liquid", "chromatographic", "determinations", "gabexate", "mesilate", "FOY", ")", ",", "prostaglandin", "E1", "PGE1", ")", ",", "PGE1-alpha-cyclodextrin", "(", "PGE1-CD", ")", ",", "C0032950#ent", "<e1>", "(", "PD", ")", "and", "C0625740#ent", "<e2>", "BF", ")", "incorporated", "in", "gel", "ointment", "investigated", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0625740", "name": "C0625740#ent", "pos": [25, 26]}}
{"token": ["Together", ",", "these", "findings", "demonstrate", "that", "C0812229#ent", "<e1>", "functions", "in", "C1535939#ent", "<e2>", "regulation", "in", "mice", "."], "h": {"id": "C0812229", "name": "C0812229#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "describe", "that", "the", "activity", "of", "the", "-99/+134", "basal", "promoter", "rat", "C1335837#ent", "<e1>", "is", "increased", "by", "C0031469#ent", "<e2>", "."], "h": {"id": "C1335837", "name": "C1335837#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [17, 18]}}
{"token": ["Zinc", "intake", "had", "no", "influence", "on", "the", "primary", "and", "secondary", "immune", "response", "C1418917#ent", "<e1>", "or", "delayed", "hypersensitivity", "to", "phytohemagglutinin-P", "(", "C0030779#ent", "<e2>", ")", "or", "human", "gamma", "globulin", "Ancona", "and", "broiler", "chicks", "."], "h": {"id": "C1418917", "name": "C1418917#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [20, 21]}}
{"token": ["There", "is", "not", "any", "signal", "in", "acrocyanosis", ",", "C0011606#ent", "<e1>", "sharp", "'s", "disease", "and", "C0852949#ent", "<e2>"], "h": {"id": "C0011606", "name": "C0011606#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0852949", "name": "C0852949#ent", "pos": [14, 15]}}
{"token": ["A", "third", "GEF", ",", "GRP3", "(", "C1413850#ent", "<e1>", ")", ",", "activated", "both", "C0034678#ent", "<e2>", "and", "Rap1", "and", "shared", "significant", "sequence", "homology", "with", "the", "calcium-", "and", "diacylglycerol-activated", "GEFs", ",", "GRP1", "and", "GRP2", "."], "h": {"id": "C1413850", "name": "C1413850#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [12, 13]}}
{"token": ["Staphylococcus", "aureus", "identified", "as", "the", "cause", "in", "most", "cases", "of", "C0270629#ent", "<e1>", "other", "bacteria", "responsible", "include", "C0085423#ent", "<e2>", "Streptococcus", "species", "Brucella", "species"], "h": {"id": "C0270629", "name": "C0270629#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [16, 17]}}
{"token": ["C0251914#ent", "<e1>", "belongs", "to", "the", "C0072354#ent", "<e2>", "a", "family", "of", "homologous", "proteins", "localized", "in", "the", "endoplasmic", "reticulum", "characterized", "by", "the", "presence", "of", "a", "thioredoxin-like", "folding", "domain"], "h": {"id": "C0251914", "name": "C0251914#ent", "pos": [0, 1]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0072354", "name": "C0072354#ent", "pos": [5, 6]}}
{"token": ["Additionally", ",", "this", "is", "the", "first", "report", "describing", "an", "elevation", "of", "serum", "C1366571#ent", "<e1>", "in", "an", "autoimmune", "or", "C0262428#ent", "<e2>"], "h": {"id": "C1366571", "name": "C1366571#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0262428", "name": "C0262428#ent", "pos": [18, 19]}}
{"token": ["C0003693#ent", "<e1>", "FLAP", ")", "functions", "as", "a", "facilitator", "of", "5-lipoxygenase", "(", "C1412361#ent", "<e2>", ")", "activity", "."], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412361", "name": "C1412361#ent", "pos": [11, 12]}}
{"token": ["The", "present", "study", "suggests", "that", "one", "potential", "therapeutic", "interest", "for", "C0073379#ent", "<e1>", "in", "neurodegenerative", "disorders", "reside", "in", "the", "reduction", "of", "C1457887#ent", "<e2>", "associated", "with", "striatal", "lesions"], "h": {"id": "C0073379", "name": "C0073379#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [20, 21]}}
{"token": ["14", "cases", "of", "C0023364#ent", "<e1>", "ictero-haemorrhagica", "observed", "on", "Reunion", "island", "with", "predominant", "or", "isolated", "C1457887#ent", "<e2>", "described", "."], "h": {"id": "C0023364", "name": "C0023364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [14, 15]}}
{"token": ["Seventy", "six", "patients", "with", "Intractable", "asthma", "re-treated", "with", "recommended", "maximal", "doses", "of", "C0032950#ent", "<e1>", "5", "days", ",", "beclomethasone", ",", "cromolyn", "sodium", "salbutamol", "and", "C0027235#ent", "<e2>", "30", "days", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027235", "name": "C0027235#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "that", "MSS4", "and", "Rab3A", "C1706512#ent", "<e1>", "are", "different", "C1366909#ent", "<e2>", "Rab3A", "."], "h": {"id": "C1706512", "name": "C1706512#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366909", "name": "C1366909#ent", "pos": [11, 12]}}
{"token": ["C1413916#ent", "<e1>", "-/-", "mice", "had", "increased", "sensitivity", "to", "the", "locomotor-activating", "and", "C3658225#ent", "<e2>", "modafinil", "."], "h": {"id": "C1413916", "name": "C1413916#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3658225", "name": "C3658225#ent", "pos": [11, 12]}}
{"token": ["Other", "than", "C3540781#ent", "<e1>", "(", "carmustine", "and", "lomustine", ")", "and", "C0076080#ent", "<e2>", ",", "no", "agents", "have", "consistently", "demonstrated", "clinically", "meaningful", "benefits", "for", "patients", "with", "gliomas", "."], "h": {"id": "C3540781", "name": "C3540781#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0076080", "name": "C0076080#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "the", "effect", "of", "beta", "3-adrenergic", "receptor", "beta(3)AR", ")", "polymorphism", "on", "lipid", "profiles", "in", "patients", "with", "C0003873#ent", "<e1>", "RA", ")", "and", "systemic", "lupus", "erythematosus", "SLE", ")", "treated", "with", "C0008269#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0008269", "name": "C0008269#ent", "pos": [29, 30]}}
{"token": ["C2987634#ent", "<e1>", "of", "group", "I", ",", "including", "1S,3R-ACPD", ",", "activated", "phosphoinositide", "hydrolysis", "C1417549#ent", "<e2>", "-", "7", "cells", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417549", "name": "C1417549#ent", "pos": [12, 13]}}
{"token": ["Conversely", ",", "loss", "of", "C0287666#ent", "<e1>", "enhanced", "C1333212#ent", "<e2>", "focus", "formation", "independently", "of", "ssDNA", "formation", ",", "suggesting", "that", "C0287666#ent", "<e1>", "might", "compete", "for", "the", "interaction", "of", "RPA", "with", "Mec1-Ddc2", "."], "h": {"id": "C1333212", "name": "C1333212#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0287666", "name": "C0287666#ent", "pos": [4, 5]}}
{"token": ["One", "of", "these", "unknown", "enzymes", ",", "C0538091#ent", "<e1>", "was", "cross-induced", "by", "sugar", "cane", "C0004681#ent", "<e2>", ",", "Solka-floc", ",", "and", "xylan", "."], "h": {"id": "C0538091", "name": "C0538091#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004681", "name": "C0004681#ent", "pos": [13, 14]}}
{"token": ["They", "are", "not", "sensitive", "to", "C0014996#ent", "<e1>", ",", "chloroform", "and", "C0041236#ent", "<e2>", "."], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [10, 11]}}
{"token": ["The", "intracellular", "infectious", "material", "sensitive", "to", "treatment", "with", "deoxycholate", ",", "Nonidet", "P-40", "or", "C0014996#ent", "<e1>", "but", "resistant", "to", "treatment", "with", "RNase", "or", "C0041236#ent", "<e2>", "."], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [22, 23]}}
{"token": ["The", "efficacy", "and", "tolerability", "of", "C0050559#ent", "<e1>", "(", "etretin", ")", "in", "severe", "C0033860#ent", "<e2>", "was", "compared", "with", "that", "of", "etretinate", "in", "a", "double-blind", "randomized", "study", "12", "weeks", "."], "h": {"id": "C0050559", "name": "C0050559#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [12, 13]}}
{"token": ["A", "highly", "sensitive", "liquid", "chromatographic-mass", "spectrometric", "procedure", "been", "developed", "to", "quantitate", "plasma", "concentrations", "of", "C0050559#ent", "<e1>", ",", "a", "dermatologic", "agent", "to", "treat", "severe", "C0033860#ent", "<e2>", "."], "h": {"id": "C0050559", "name": "C0050559#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [23, 24]}}
{"token": ["The", "C0032002#ent", "<e1>", "is", "the", "C0014130#ent", "<e2>", "for", "the", "regulation", "of", "various", "physiologic", "and", "metabolic", "processes"], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [5, 6]}}
{"token": ["Empty", "sella", "syndrome", "an", "anatomical", "and", "clinical", "entity", "of", "intrasellar", "reposition", "of", "the", "CSF", "and", "compression", "of", "the", "C0032002#ent", "<e1>", "resulting", "in", "a", "clinical", "picture", "headache", ",", "visual", "field", "defect", "CSF", "rhinorrhea", "some", "C0014130#ent", "<e2>"], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [33, 34]}}
{"token": ["In", "vitro", "duodenal", "calcium", "net", "flux", "correlated", "with", "serum", "1,25(OH)2D3", "in", "HM", "and", "C3273279#ent", "<e1>", "and", "in", "C1853926#ent", "<e2>", "and", "NF", "."], "h": {"id": "C3273279", "name": "C3273279#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1853926", "name": "C1853926#ent", "pos": [17, 18]}}
{"token": ["In", "vivo", "both", "young", "and", "adult", "rats", "showed", "increased", "levels", "of", "phosphorylated", "C2987024#ent", "<e1>", "in", "neuronal", "tissues", "injection", "of", "DNA-toxin", "C0015133#ent", "<e2>", "."], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [20, 21]}}
{"token": ["In", "summary", ",", "C1419227#ent", "<e1>", "was", "activated", "by", "secretory", "stimuli", "modulated", "the", "secretory", "pathway", "downstream", "of", "C1413043#ent", "<e2>", "+", "influx", ",", "partly", "through", "regulation", "of", "cytoskeletal", "organization"], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [16, 17]}}
{"token": ["Inosine-5'-monophosphate", "dehydrogenase", "C1512600#ent", "<e1>", ")", "is", "an", "attractive", "drug", "target", "the", "control", "of", "C0747256#ent", "<e2>"], "h": {"id": "C1512600", "name": "C1512600#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [13, 14]}}
{"token": ["C0101555#ent", "<e1>", "profiles", "of", "C0031651#ent", "<e2>", "(", "PFK", ")", "activity", "were", "determined", "in", "both", "crude", "and", "Sephadex", "G-25-filtered", "fractions", "from", "rabbit", "dental", "pulp"], "h": {"id": "C0101555", "name": "C0101555#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031651", "name": "C0031651#ent", "pos": [4, 5]}}
{"token": ["Among", "the", "down-regulated", "genes", "in", "LYP9", ",", "there", "is", "an", "essential", "C0027203#ent", "<e1>", "in", "photorespiration", ",", "alanine", ":", "C0061759#ent", "<e2>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0061759", "name": "C0061759#ent", "pos": [18, 19]}}
{"token": ["Sequence", "analysis", "that", "it", "contained", "at", "least", "six", "C1412821#ent", "<e1>", "including", "halU", ",", "halR", ",", "proC8", ",", "halT1", ",", "C1512213#ent", "<e2>", "and", "halT3", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1512213", "name": "C1512213#ent", "pos": [19, 20]}}
{"token": ["C1427080#ent", "<e1>", ",", "rather", "than", "C1420870#ent", "<e2>", ",", "has", "now", "become", "a", "candidate", "gene", "for", "5-HT-related", "affective", "disorders"], "h": {"id": "C1427080", "name": "C1427080#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [5, 6]}}
{"token": ["Transfection", "of", "HUVEC", "with", "dominant", "negative", "p53", "cDNA", "prevented", "the", "C1426033#ent", "<e1>", "increases", "in", "C1420626#ent", "<e2>", "and", "p27", "promoter", "activity", "protein", "level", "decreases", "in", "thymidine", "incorporation", ",", "and", "capillary-like", "tube", "formation", "."], "h": {"id": "C1426033", "name": "C1426033#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [14, 15]}}
{"token": ["The", "drug", "combination", "administration", "periods", "in", "the", "PPI", "group", "were", "LPZ", "30", "mg", ",", "C1537503#ent", "<e1>", "400", "mg", ",", "MTZ", "500", "mg", "(", "C0024266#ent", "<e2>", "group", ")", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024266", "name": "C0024266#ent", "pos": [23, 24]}}
{"token": ["With", "RT-PCR", ",", "cells", "cultured", "in", "MEM/10", "showed", "transient", "increases", "in", "Cx43", "and", "Cx46", "mRNA", "expression", ",", "whereas", "Cx32", "and", "C1415077#ent", "<e1>", "decreased", "and", "C1415079#ent", "<e2>", "and", "Cx37", "were", "unchanged", "."], "h": {"id": "C1415077", "name": "C1415077#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1415079", "name": "C1415079#ent", "pos": [24, 25]}}
{"token": ["Both", "the", "peroxidation", "of", "synaptosomal", "membranes", "the", "inhibition", "of", "GABA", "uptake", "by", "C1421531#ent", "<e1>", "were", "enhanced", "by", "the", "addition", "of", "ADP", "and", "C1416373#ent", "<e2>", "."], "h": {"id": "C1421531", "name": "C1421531#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416373", "name": "C1416373#ent", "pos": [22, 23]}}
{"token": ["SP-A", "binds", "C0216971#ent", "<e1>", "(", "DPPC", ")", "and", "galactosylceramide", "(", "C4048351#ent", "<e2>", ")", ",", "induces", "liposome", "aggregation", "and", "regulates", "the", "uptake", "and", "secretion", "of", "surfactant", "lipids", "by", "alveolar", "type", "II", "cells", "in", "vitro"], "h": {"id": "C0216971", "name": "C0216971#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4048351", "name": "C4048351#ent", "pos": [10, 11]}}
{"token": ["The", "natural", "history", "one", "of", "a", "deteriorative", "course", ",", "with", "progressive", "neurological", "manifestations", "sensorineural", "deafness", "C0036572#ent", "<e1>", "from", "infancy", ",", "C0029124#ent", "<e2>", "and", "a", "peripheral", "polyneuropathy"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [20, 21]}}
{"token": ["Most", "frequently", "the", "central", "nervous", "system", "affected", ",", "with", "psychomotor", "retardation", "C0036572#ent", "<e1>", ",", "nystagmus", ",", "ophthalmoparesis", ",", "C0029124#ent", "<e2>", "ataxia", ",", "dystonia", ",", "or", "respiratory", "failure"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [18, 19]}}
{"token": ["The", "point", "mutations", "of", "highly", "conserved", "residues", "within", "the", "N-terminal", "domain", "of", "C1425128#ent", "<e1>", "reduced", "C1425128#ent", "<e1>", "kinase", "activity", "well", "as", "human", "C1424857#ent", "<e1>", "binding", "."], "h": {"id": "C1425128", "name": "C1425128#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1424857", "name": "C1424857#ent", "pos": [22, 23]}}
{"token": ["In", "most", "cases", "increased", "expression", "is", "associated", "with", "mutations", "in", "one", "C0002085#ent", "<e1>", "of", "the", "C1705526#ent", "<e2>", "loss", "of", "the", "other", "C0002085#ent", "<e1>", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [11, 12]}}
{"token": ["C1439342#ent", "<e1>", "GMF", ")", "immobilized", "on", "agarose", "beads", "retained", "the", "same", "C0026249#ent", "<e2>", "and", "morphological", "transforming", "activities", "as", "free", "GMF", "when", "tested", "on", "glioblasts", "."], "h": {"id": "C1439342", "name": "C1439342#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [11, 12]}}
{"token": ["No", "significant", "changes", "in", "fructosamine", "were", "detected", "in", "dogs", "or", "cats", "with", "hyperproteinaemia", "or", "C0020433#ent", "<e1>", ",", "or", "in", "cats", "with", "C0020473#ent", "<e2>", "or", "azotaemia", "."], "h": {"id": "C0020433", "name": "C0020433#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [21, 22]}}
{"token": ["Mutation", "of", "a", "conserved", "cysteine", "in", "the", "C1427067#ent", "<e1>", "domain", "of", "an", "Ii", "fusion", "protein", "reduced", "resistance", "to", "C1332807#ent", "<e2>"], "h": {"id": "C1427067", "name": "C1427067#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [18, 19]}}
{"token": ["Further", "characterization", "of", "C1419805#ent", "<e1>", "revealed", "that", "it", "is", "a", "C0600449#ent", "<e2>", "yeast", "and", "belongs", "to", "a", "newly", "identified", "gene", "family", "promotes", "protein", "ubiquitination", "degradation", "."], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0600449", "name": "C0600449#ent", "pos": [10, 11]}}
{"token": ["The", "alteration", "of", "steady", "state", "C1418754#ent", "<e1>", "mRNA", "in", "HepG2", "cells", "C0534519#ent", "<e2>", "(", "IL-1beta", ")", "and", "tumor", "necrosis", "factor-alpha", "TNF-alpha", ")", ",", "was", "investigated", "relative", "to", "acute-phase", "serum", "amyloid", "A", "(", "A-SAA", ")", "mRNA", "."], "h": {"id": "C1418754", "name": "C1418754#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [11, 12]}}
{"token": ["Approximately", "7", "%", "of", "the", "dose", "was", "accounted", "by", "the", "products", "of", "CPIC", ",", "which", "included", "the", "C1260386#ent", "<e1>", "conjugate", "and", "C3812677#ent", "<e2>", "excreted", "in", "bile", "and", "urine", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3812677", "name": "C3812677#ent", "pos": [21, 22]}}
{"token": ["C3714552#ent", "<e1>", "association", "with", "a", "C0042769#ent", "<e2>", "high", "CSF", "protein", ",", "diminished", "nerve", "conduction", "velocities", ",", "and", "a", "prompt", "recovery", "were", "compatible", "with", "the", "diagnosis", "of", "Guillain-Barr\u00e9", "syndrome"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [5, 6]}}
{"token": ["The", "electrophysiological", "effects", "C0128476#ent", "<e1>", ",", "a", "new", "C0020615#ent", "<e2>", "is", "an", "alpha", "2-adrenoceptor", "antagonist", "were", "assessed", "in", "the", "reserpinized", "ventricular", "myocardium", "the", "guinea-pig", "."], "h": {"id": "C0128476", "name": "C0128476#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [8, 9]}}
{"token": ["These", "two", "C0678933#ent", "<e1>", "C4A", "and", "C4B", ",", "are", "highly", "C1334043#ent", "<e2>", "in", "primary", "structure", "encode", "proteins", "with", "different", "functional", "activities", "."], "h": {"id": "C0678933", "name": "C0678933#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}}
{"token": ["Cyclosporine", "A", "C0010592#ent", "<e1>", ")", "treatment", "was", "evaluated", "in", "52", "patients", "with", "severe", "C0026896#ent", "<e2>", "MG", ")", "whose", "illness", "was", "not", "controlled", "by", "anticholinesterase", "drugs", "thymectomy", ",", "corticosteroids", ",", "and", "azathioprine", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "a", "female", "patient", "with", "Arnold", "Chiari", "type", "I", "malformation", "atypical", "Rett", "syndrome", "by", "postnatal", "onset", "microcephaly", "stereotypic", "hand", "movements", "C0004134#ent", "<e1>", ",", "severe", "developmental", "delay", "intractable", "C0014549#ent", "<e2>", "and", "a", "MECP2", "mutation", "with", "a", "unique", "set", "of", "clinical", "findings"], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [28, 29]}}
{"token": ["In", "vitro", "paracetamol", "had", "no", "effect", "on", "C1418385#ent", "<e1>", "whereas", "TA", "induced", "a", "significant", "inhibition", "of", "C0164371#ent", "<e2>", "."], "h": {"id": "C1418385", "name": "C1418385#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [16, 17]}}
{"token": ["C1290344#ent", "<e1>", "the", "most", "frequent", "C0035242#ent", "<e2>", "high-resolution", "computed", "tomography", "CT", ")", "is", "the", "cornerstone", "of", "management", "."], "h": {"id": "C1290344", "name": "C1290344#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [5, 6]}}
{"token": ["All", "neutrophils", "had", "a", "greater", "C1412696#ent", "<e1>", "to", "EDP", "from", "C1705543#ent", "<e2>", "tissue", "compared", "to", "AOD", "and", "control", "aorta"], "h": {"id": "C1412696", "name": "C1412696#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [10, 11]}}
{"token": ["C3810562#ent", "<e1>", "(", "HJV", ";", "also", "called", "repulsive", "guidance", "molecule", "c", "C1415529#ent", "<e2>", ")", "is", "the", "third", "member", "of", "this", "family", ",", "and", "mutations", "in", "this", "gene", "result", "a", "form", "of", "juvenile", "hemochromatosis", "type", "2A", "."], "h": {"id": "C3810562", "name": "C3810562#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415529", "name": "C1415529#ent", "pos": [11, 12]}}
{"token": ["The", "C0035678#ent", "<e1>", "HIV-1", "encoding", "the", "C0030946#ent", "<e2>", ",", "reverse", "transcriptase", "RT", ")", "and", "endonuclease", "has", "been", "expressed", "in", "Escherichia", "coli"], "h": {"id": "C0035678", "name": "C0035678#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [6, 7]}}
{"token": ["We", "next", "examined", "whether", "SDF-1alpha", "played", "roles", "in", "EOC", "progression", ",", "including", "in", "proliferation", ",", "cell", "motility", "attachment", "to", "C0063242#ent", "<e1>", ",", "and", "the", "in", "vivo", "development", "of", "peritoneal", "metastasis", "C1332823#ent", "<e2>", "."], "h": {"id": "C0063242", "name": "C0063242#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [30, 31]}}
{"token": ["We", "suggest", "that", "the", "C0039082#ent", "<e1>", "be", "named", "C0011989#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0011989", "name": "C0011989#ent", "pos": [8, 9]}}
{"token": ["The", "apparent", "affinity", "of", "C1537503#ent", "<e1>", "for", "GS17C", ",", "a", "CaM-binding", "peptide", "of", "C1504769#ent", "<e2>", ",", "is", "weakened", "by", "CaT", ",", "suggesting", "CaT", "competes", "with", "C1537503#ent", "<e1>", "for", "the", "peptide", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [13, 14]}}
{"token": ["Thus", "in", "the", "1:1", "complex", "of", "C1504769#ent", "<e1>", "and", "C1537503#ent", "<e2>", ",", "the", "CaM", "molecule", "almost", "always", "associated", "with", "C-terminus", "of", "C1504769#ent", "<e1>", ",", "indicating", "preferential", "CaM-binding", "to", "the", "C-terminal", "region"], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [6, 7]}}
{"token": ["Before", "activation", ",", "they", "express", "low", "or", "undetectable", "levels", "of", "NK", "receptors", "upon", "activation", "with", "C1522405#ent", "<e1>", "they", "expressed", "significant", "levels", "of", "activating", "NK", "receptors", "C3538766#ent", "<e2>", "and", "NKG2D", "."], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3538766", "name": "C3538766#ent", "pos": [25, 26]}}
{"token": ["The", "enzymes", "tested", "included", ":", "endoglucanase", ",", "endoxylanase", ",", "C0005223#ent", "<e1>", ",", "laccase", ",", "peroxidase", ",", "polyphenoloxidase", ",", "C4048300#ent", "<e2>", "and", "beta-xylosidase", "."], "h": {"id": "C0005223", "name": "C0005223#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4048300", "name": "C4048300#ent", "pos": [18, 19]}}
{"token": ["In", "addition", "to", "their", "effects", "on", "IK", ",", "both", "diacylhydrazines", "were", "much", "weaker", "C3494348#ent", "<e1>", "of", "the", "voltage-dependent", "sodium", "current", "C1416431#ent", "<e2>", ")", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1416431", "name": "C1416431#ent", "pos": [20, 21]}}
{"token": ["To", "report", "a", "case", "of", "C0038220#ent", "<e1>", "a", "patient", "with", "C3810813#ent", "<e2>", "AHS", ")", "that", "was", "controlled", "successfully", "using", "continuous", "intravenous", "infusion", "diazepam", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3810813", "name": "C3810813#ent", "pos": [10, 11]}}
{"token": ["Medications", "associated", "with", "allergic", ",", "inflammatory", ",", "or", "cytotoxic", "colitis", "gold", "compounds", "nonsteroidal", "antiinflammatory", "drugs", "C0025741#ent", "<e1>", ",", "flucytosine", ",", "methotrexate", ",", "C0036075#ent", "<e2>", ",", "and", "sulfasalazine", "."], "h": {"id": "C0025741", "name": "C0025741#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0036075", "name": "C0036075#ent", "pos": [22, 23]}}
{"token": ["Dent's", "disease", "primary", "hyperoxaluria", "inherited", "causes", "of", "C3671880#ent", "<e1>", "are", "both", "associated", "with", "nephrocalcinosis", "and", "C0451641#ent", "<e2>", "in", "early", "childhood", "renal", "failure", "can", "occur", "at", "any", "age", "but", "is", "seen", "more", "often", "in", "adulthood", "."], "h": {"id": "C3671880", "name": "C3671880#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [15, 16]}}
{"token": ["The", "activities", "of", "type", "1", "phosphatase", "phosphotyrosyl", "phosphatase", "gray", "matter", "of", "C1335236#ent", "<e1>", "both", "gray", "and", "white", "matters", "significantly", "lower", "in", "C2931257#ent", "<e2>", "brains", "than", "in", "controls", "."], "h": {"id": "C1335236", "name": "C1335236#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2931257", "name": "C2931257#ent", "pos": [21, 22]}}
{"token": ["A", "case", "of", "a", "7-year-old", "male", "with", "epilepsy", "who", "developed", "non-convulsive", "status", "epilepticus", "NCSE", ")", "with", "electroclinical", "features", "consistent", "with", "of", "atypical", "absence", "C0751495#ent", "<e1>", "after", "adjunctive", "antiepileptic", "therapy", "tiagabine", "(", "C1335239#ent", "<e2>", ")", "is", "reported", "."], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1335239", "name": "C1335239#ent", "pos": [31, 32]}}
{"token": ["Ocular", "infection", "guinea", "pigs", "the", "guinea", "pig", "inclusion", "conjunctivitis", "C3889469#ent", "<e1>", ")", "strain", "of", "Chlamydia", "psittaci", "a", "clinical", "condition", "of", "acute", "C0009770#ent", "<e2>", "humans", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009770", "name": "C0009770#ent", "pos": [21, 22]}}
{"token": ["The", "adsorption", "of", "C0030956#ent", "<e1>", "onto", "a", "lipid", "monolayer", "showed", "that", "the", "presence", "of", "C3273549#ent", "<e2>", "did", "not", "affect", "C0030956#ent", "<e1>", "adsorption", "."], "h": {"id": "C3273549", "name": "C3273549#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}}
{"token": ["A", "34-year-old", "woman", "with", "secondary", "amenorrhoea", "C0553573#ent", "<e1>", "pregnant", "after", "treatment", "with", "C0009008#ent", "<e2>", "."], "h": {"id": "C0553573", "name": "C0553573#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009008", "name": "C0009008#ent", "pos": [12, 13]}}
{"token": ["Five", "patients", "with", "C0553573#ent", "<e1>", "secondary", "amenorrhea", "did", "not", "respond", "to", "C0009008#ent", "<e2>", "with", "a", "gonadotropin", "or", "estrogen", "surge", "treated", "with", "mug", "of", "luteinizing", "hormone", "follicle-stimulating", "hormone-releasing", "hormone", "LH-RH", ")", ",", "self-administered", "subcutaneously", "8", "hours", "for", "14", "days", "."], "h": {"id": "C0553573", "name": "C0553573#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009008", "name": "C0009008#ent", "pos": [11, 12]}}
{"token": ["Major", "histocompatibility", "complex", "MHC", ")", "class", "I", "genes", ",", "C1417162#ent", "<e1>", "and", "MICB", ",", "are", "located", "C1427959#ent", "<e2>", "to", "human", "leukocyte", "antigen", "B", "HLA-B", ")", "on", "chromosome", "6"], "h": {"id": "C1417162", "name": "C1417162#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1427959", "name": "C1427959#ent", "pos": [16, 17]}}
{"token": ["The", "C1417162#ent", "<e1>", "and", "PERB11.2", "genes", "approximately", "40", "kb", "and", "160", "kb", "C1427959#ent", "<e2>", "of", "HLA-B", ",", "respectively", "."], "h": {"id": "C1417162", "name": "C1417162#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1427959", "name": "C1427959#ent", "pos": [12, 13]}}
{"token": ["During", "studies", "of", "G-protein", "coupled", "receptor", "GPCR", ")", "C0017337#ent", "<e1>", "involved", "with", "C0235946#ent", "<e2>", "neurogenesis", ",", "the", "first", "lysophospholipid", "receptor", "gene", "lpA1/vzg-1", ")", "was", "isolated", "(", "Hecht", "et", "al.", ",", "J.", "Cell", "Biol", ".", ","], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0235946", "name": "C0235946#ent", "pos": [12, 13]}}
{"token": ["These", "results", "demonstrate", "usefulness", "of", "multivariate", "linkage", "analyses", "detect", "loci", "with", "pleiotropic", "effects", "on", "genetically", "correlated", "traits", "and", "suggest", "overlap", "between", "the", "C0017337#ent", "<e1>", "influencing", "blood", "pressure", "those", "contributing", "to", "C0235946#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0235946", "name": "C0235946#ent", "pos": [30, 31]}}
{"token": ["These", "results", "suggest", "that", "C0017337#ent", "<e1>", "contributing", "to", "the", "facial", "and", "some", "of", "the", "C0037285#ent", "<e2>", "Down", "syndrome", "exist", "in", "the", "chromosomal", "region", "to", "D21S55", "in", "band", "21q22.1"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [14, 15]}}
{"token": ["Boolean", "logic", "used", "to", "model", "the", "effect", "of", "these", "carbon/light", "interactions", "on", "three", "target", "genes", "involved", "in", "nitrogen", "assimilation", "asparagine", "synthetase", "C3811213#ent", "<e1>", "and", "ASN2", ")", "and", "C1415119#ent", "<e2>", "GLN2", ")", "."], "h": {"id": "C3811213", "name": "C3811213#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1415119", "name": "C1415119#ent", "pos": [27, 28]}}
{"token": ["The", "irritation", "causes", "the", "powerful", "C0010200#ent", "<e1>", "paroxysms", "of", "C0043168#ent", "<e2>"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0043168", "name": "C0043168#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "glycosaminoglycans-mediated", "binding", "B.", "henselae", "to", "soluble", "C1706331#ent", "<e1>", "showed", "that", "Hep", "but", "not", "C0079224#ent", "<e2>", "inhibited", "the", "bacterium", "binding", "C1706331#ent", "<e1>", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079224", "name": "C0079224#ent", "pos": [15, 16]}}
{"token": ["Partial", "beta-antagonists", "beta-blockers", "with", "weak", "intrinsic", "sympathomimetic", "activity", "do", "not", "possess", "sufficient", "C2987634#ent", "<e1>", "activity", "to", "counteract", "their", "own", "C0027048#ent", "<e2>", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0027048", "name": "C0027048#ent", "pos": [19, 20]}}
{"token": ["The", "C0242974#ent", "<e1>", "muscimol", "(", "0.3", "mM", ")", "and", "C0284941#ent", "<e2>", "(", "1", "mM", ")", ",", "produced", "a", "slight", "inhibition", "of", "contractions", "and", "reduced", "the", "effects", "of", "subsequent", "challenge", "with", "GABA", "."], "h": {"id": "C0242974", "name": "C0242974#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0284941", "name": "C0284941#ent", "pos": [9, 10]}}
{"token": ["To", "explore", "the", "relationship", "of", "symptomatic", "C0267072#ent", "<e1>", "heartburn", "and", "their", "association", "with", "C0014858#ent", "<e2>", "we", "have", "performed", "a", "retrospective", "assessment", "1035", "patient", "evaluations", "performed", "at", "our", "gastrointestinal", "laboratory"], "h": {"id": "C0267072", "name": "C0267072#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014858", "name": "C0014858#ent", "pos": [13, 14]}}
{"token": ["Clinical", "investigations", "thrombolysis", "in", "C0917798#ent", "<e1>", "different", "plasminogen-activators", "such", "as", "urokinase", ",", "streptokinase", ",", "and", "C0032143#ent", "<e2>", "either", "given", "systemically", "or", "locally", "via", "an", "intraarterial", "catheter"], "h": {"id": "C0917798", "name": "C0917798#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [15, 16]}}
{"token": ["C0033497#ent", "<e1>", "and", "mexiletine", "have", "been", "effective", "in", "preventing", "C0042510#ent", "<e2>", "for", "over", "3", "years", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [9, 10]}}
{"token": ["Consideration", "of", "C4023113#ent", "<e1>", "important", "in", "the", "differential", "diagnosis", "C0085786#ent", "<e2>"], "h": {"id": "C4023113", "name": "C4023113#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085786", "name": "C0085786#ent", "pos": [9, 10]}}
{"token": ["Its", "development", "was", "strongly", "influenced", "by", "the", "treatment", "of", "C0024131#ent", "<e1>", "and", "STDs", "(", "C0036918#ent", "<e2>", "."], "h": {"id": "C0024131", "name": "C0024131#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036918", "name": "C0036918#ent", "pos": [14, 15]}}
{"token": ["Endocytic", "proteins", "C1414118#ent", "<e1>", "synaptojanin", "1", "well", "as", "GTPase-activating", "protein", "C1970471#ent", "<e2>", "bound", "the", "neuron-specific", "variant", "the", "SH3A", "domain", "with", "higher", "affinity", "than", "ubiquitously", "expressed", "SH3A", "."], "h": {"id": "C1414118", "name": "C1414118#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1970471", "name": "C1970471#ent", "pos": [10, 11]}}
{"token": ["After", "exposure", "to", "%", "C1822723#ent", "<e1>", ",", "the", "membranous", "C1825023#ent", "<e2>", "expression", "was", "decreased", ",", "the", "cytoplasmic", "C1825023#ent", "<e2>", "expression", "was", "increased", "(", "P", "<", "0.01", ")", "as", "the", "exposure", "time", "on", "."], "h": {"id": "C1822723", "name": "C1822723#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1825023", "name": "C1825023#ent", "pos": [9, 10]}}
{"token": ["Neither", "indomethacin", "nor", "C0068334#ent", "<e1>", "changed", "baseline", "values", "or", "C4025182#ent", "<e2>", "decreases", "in", "renal", "plasma", "flow", "glomerular", "filtration", "rate"], "h": {"id": "C0068334", "name": "C0068334#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4025182", "name": "C4025182#ent", "pos": [9, 10]}}
{"token": ["The", "hyperpolarizing", "responses", "to", "these", "C0035064#ent", "<e1>", "were", "not", "affected", "by", "indomethacin", "or", "C0068821#ent", "<e2>", "(", "L-NOARG", ")", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0068821", "name": "C0068821#ent", "pos": [13, 14]}}
{"token": ["The", "final", "'", "complex", "'", "or", "processed", "oligosaccharide", "structure", "approximately", "two-thirds", "less", "C0024742#ent", "<e1>", ",", "was", "insensitive", "to", "C2681929#ent", "<e2>", "had", "an", "apparent", "Mr", "of", "2300", "as", "estimated", "by", "gel", "filtration"], "h": {"id": "C0024742", "name": "C0024742#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2681929", "name": "C2681929#ent", "pos": [18, 19]}}
{"token": ["The", "ability", "of", "the", "less", "purified", "C0001473#ent", "<e1>", "to", "stimulate", "C0012888#ent", "<e2>", "helicase", "fashion", "is", "probably", "due", "to", "the", "presence", "of", "the", "DNA-binding", "protein"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012888", "name": "C0012888#ent", "pos": [10, 11]}}
{"token": ["C0026794#ent", "<e1>", "of", "the", "C1420188#ent", "<e2>", "enzyme", "superfamily", "control", "the", "glucuronidation", "of", "metabolites", "of", "aromatic", "hydrocarbons", "of", "N-oxidized", "aromatic", "amines", "have", "been", "identified", "in", "rats", "and", "humans", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420188", "name": "C1420188#ent", "pos": [4, 5]}}
{"token": ["Our", "results", "suggest", "that", "a", "chronic", "exposure", "to", "C2347556#ent", "<e1>", "during", "adolescence", "C2712370#ent", "<e2>", "the", "susceptibility", "to", "acquire", "cocaine", "self-administration", ",", "in", "a", "sex-specific", "fashion", "."], "h": {"id": "C2347556", "name": "C2347556#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [12, 13]}}
{"token": ["The", "C1306759#ent", "<e1>", "also", "markedly", "attenuated", "by", "C0543495#ent", "<e2>", "administered", "10", "min", "post-challenge", ",", "when", "mast", "cells", "already", "been", "degranulated", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [7, 8]}}
{"token": ["In", "mouse", "cells", "however", ",", "equivalent", "levels", "of", "large", "C1710492#ent", "<e1>", "to", "be", "expressed", "from", "both", "wild-type", "and", "recombinant", "C0242965#ent", "<e2>", ",", "suggesting", "a", "relationship", "between", "the", "level", "of", "enhancer", "activity", "the", "host", "cell"], "h": {"id": "C1710492", "name": "C1710492#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [19, 20]}}
{"token": ["The", "allosteric", "modulation", "[", "3H", "]", "C0027849#ent", "<e1>", "binding", "by", "C0009214#ent", "<e2>", "was", "abolished", "with", "increasing", "ionic", "strength"], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009214", "name": "C0009214#ent", "pos": [10, 11]}}
{"token": ["Renal", "involvement", "in", "these", "C0012634#ent", "<e1>", "is", "characterized", "by", "a", "pauci-immune", "segmental", "necrotizing", "and", "C0403416#ent", "<e2>", "is", "strongly", "associated", "with", "circulating", "antineutrophil", "cytoplasmic", "autoantibodies"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0403416", "name": "C0403416#ent", "pos": [14, 15]}}
{"token": ["Moreover", "renal", "biopsy", "to", "detect", "underlying", "C0012634#ent", "<e1>", "and", "gave", "indications", "to", "initiate", "specific", "therapy", "particularly", "in", "C0403416#ent", "<e2>", "outcome", "of", "which", "remained", "unfavourable", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0403416", "name": "C0403416#ent", "pos": [17, 18]}}
{"token": ["A", "pyridocarbazole", "platinum", "complex", ",", "which", "matches", "the", "overall", "shape", "of", "the", "natural", "product", "C0075193#ent", "<e1>", ",", "binds", "with", "high", "affinity", "at", "the", "adenosine", "triphosphate", "binding", "site", "glycogen", "synthase", "kinase", "3", "C3853562#ent", "<e2>", ")", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3853562", "name": "C3853562#ent", "pos": [31, 32]}}
{"token": ["We", "have", "shown", "that", "the", "C0914069#ent", "<e1>", "PAF", ")", "participates", "in", "young", "animals", "such", "C0403592#ent", "<e2>"], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0403592", "name": "C0403592#ent", "pos": [14, 15]}}
{"token": ["AF9", "sequences", "fused", "into", "the", "mouse", "C0919528#ent", "<e1>", "that", "expression", "of", "the", "C3274681#ent", "<e2>", "fusion", "gene", "occurred", "from", "endogenous", "Mll", "transcription", "control", "elements", "as", "in", "t(9;11", ")", "found", "in", "human", "leukemias"], "h": {"id": "C0919528", "name": "C0919528#ent", "pos": [6, 7]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274681", "name": "C3274681#ent", "pos": [12, 13]}}
{"token": ["The", "kinetic", "data", "strongly", "indicate", "that", "these", "C0086376#ent", "<e1>", "are", "indeed", "bona", "fide", "C1332740#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332740", "name": "C1332740#ent", "pos": [13, 14]}}
{"token": ["The", "endothelial", "and", "inducible", "nitric-oxide", "synthase", "C1328053#ent", "<e1>", "and", "iNOS", "respectively", ")", "C1417679#ent", "<e2>", "are", "also", "expressed", "in", "this", "nephron", "segment", "are", "thought", "to", "play", "a", "role", "in", "regulating", "urinary", "sodium", "concentration", "."], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Lis1", ",", "the", "product", "of", "the", "Pafah1b1", "gene", "is", "a", "component", "of", "the", "brain", "platelet-activating", "factor", "acetylhydrolase", "1b", "Pafah1b", ")", "complex", ",", "and", "binds", "to", "phosphorylated", "C1413898#ent", "<e1>", "in", "response", "to", "C1568702#ent", "<e2>", "."], "h": {"id": "C1413898", "name": "C1413898#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1568702", "name": "C1568702#ent", "pos": [31, 32]}}
{"token": ["Examining", "the", "primary", "structure", "IRAK", ",", "we", "identified", "three", "putative", "C1826724#ent", "<e1>", "phosphorylation", "sites", ";", "C0667917#ent", "<e2>", "phosphorylated", "peptide", "1", "RTAS", ")", "within", "the", "death", "domain", "domain", "Thr66", ",", "which", "is", "highly", "conserved", "among", "all", "IRAK", "family", "members"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0667917", "name": "C0667917#ent", "pos": [15, 16]}}
{"token": ["Although", "relatively", "uncommon", ",", "this", "diagnosis", "should", "be", "considered", "in", "an", "elderly", "person", "C0011168#ent", "<e1>", ",", "a", "history", "of", "C0005745#ent", "<e2>", ",", "and", "the", "proper", "family", "background"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [19, 20]}}
{"token": ["Chondromodulin-I", "(", "C1424681#ent", "<e1>", ")", "is", "a", "C0072522#ent", "<e2>", "that", "stimulates", "the", "growth", "of", "chondrocytes", "and", "inhibits", "angiogenesis", "in", "vitro"], "h": {"id": "C1424681", "name": "C1424681#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [7, 8]}}
{"token": ["Chondromodulin-I", "(", "C1424681#ent", "<e1>", ")", "is", "a", "small", "C0072522#ent", "<e2>", "that", "is", "abundant", "in", "fetal", "cartilage", "."], "h": {"id": "C1424681", "name": "C1424681#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [8, 9]}}
{"token": ["This", "is", "expected", "since", "C3273515#ent", "<e1>", "and", "MASP-2", "are", "bound", "to", "the", "mannan", "via", "C1413599#ent", "<e2>", "."], "h": {"id": "C3273515", "name": "C3273515#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413599", "name": "C1413599#ent", "pos": [14, 15]}}
{"token": ["C3273515#ent", "<e1>", "activity", "correlated", "with", "C1413599#ent", "<e2>", "concentration", ",", "as", "did", "MASP-2", "activity", "(", "in", "both", "cases", ":", "p<0.0001", ")", "."], "h": {"id": "C3273515", "name": "C3273515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413599", "name": "C1413599#ent", "pos": [5, 6]}}
{"token": ["The", "gene", "(", "C1839730#ent", "<e1>", ")", "encoding", "phosphoribosylpyrophosphate", "(", "PRPP", ")", "C0023689#ent", "<e2>", "has", "been", "cloned", "from", "a", "library", "of", "Bacillus", "subtilis", "DNA", "complementation", "of", "an", "Escherichia", "coli", "prs", "mutation"], "h": {"id": "C1839730", "name": "C1839730#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023689", "name": "C0023689#ent", "pos": [11, 12]}}
{"token": ["Although", "genetic", "experiments", "shown", "that", "C2699751#ent", "<e1>", "are", "essential", "for", "C1539078#ent", "<e2>", "yeast", "and", "in", "rapidly", "proliferating", "vertebrate", "cells", "in", "vitro", "new", "experiments", "indicate", "they", "may", "be", "dispensible", "in", "specific", "developmental", "and", "physiological", "processes"], "h": {"id": "C2699751", "name": "C2699751#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [10, 11]}}
{"token": ["Leptin", "increased", "C3538819#ent", "<e1>", "mRNA", "to", "control", "levels", "Ob/Ob", "mice", ",", "but", "had", "no", "effect", "C1883559#ent", "<e2>"], "h": {"id": "C3538819", "name": "C3538819#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [15, 16]}}
{"token": ["Both", "C0132497#ent", "<e1>", "(", "10", "to", "100", "mg/kg", ")", "and", "C0600832#ent", "<e2>", "(", "0.3", "to", "3", "mg/kg", ")", "dose-dependently", "inhibited", "gastric", "secretion", "pylorus", "ligated", "rats", "."], "h": {"id": "C0132497", "name": "C0132497#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0600832", "name": "C0600832#ent", "pos": [10, 11]}}
{"token": ["The", "DNA", "sequence", "an", "C1412821#ent", "<e1>", "ORF", ")", "corresponding", "to", "the", "murine", "adenovirus", "type", "1", "Mav1", ")", "C0030946#ent", "<e2>", "determined", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [17, 18]}}
{"token": ["The", "DNA", "sequence", "an", "C1412821#ent", "<e1>", "ORF", ")", "corresponding", "to", "the", "canine", "adenovirus", "type", "1", "Can1", ")", "C0030946#ent", "<e2>", "determined", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [17, 18]}}
{"token": ["To", "evaluate", "the", "electrophysiological", "changes", ",", "blood", "flow", "index", "vascular", "endothelial", "growth", "factor", "VEGF", ")", ",", "C0015683#ent", "<e1>", "s-FAS", ")", ",", "and", "intercellular", "adhesion", "molecule", "I-CAM", ")", "in", "C0011882#ent", "<e2>"], "h": {"id": "C0015683", "name": "C0015683#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011882", "name": "C0011882#ent", "pos": [28, 29]}}
{"token": ["Significant", "numbers", "of", "patients", "with", "C0001175#ent", "<e1>", "AIDS", ")", "develop", "C0007684#ent", "<e2>", "in", "macrophages", "and", "microglial", "cells"], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007684", "name": "C0007684#ent", "pos": [10, 11]}}
{"token": ["Multivariate", "discriminant", "analysis", "definition", "of", "cytokine", ",", "matrix", "metalloproteinases", "MMP", ")", ",", "and", "tissue", "inhibitors", "C0025543#ent", "<e1>", "(", "TIMP", ")", "levels", "in", "synovial", "fluid", "C1705295#ent", "<e2>", ")", "of", "patients", "with", "rotator", "cuff", "tears", "other", "shoulder", "lesions"], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705295", "name": "C1705295#ent", "pos": [24, 25]}}
{"token": ["These", "results", "suggest", "that", "C0812246#ent", "<e1>", "and", "IFN-gamma", "play", "a", "protective", "role", "in", "C0149512#ent", "<e2>", "HSV-1", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [13, 14]}}
{"token": ["The", "receptors", "Notch1", "and", "Notch2", ",", "members", "of", "the", "DSL", "family", "of", "Notch", "ligands", "and", "the", "target", "C1417679#ent", "<e1>", "in", "the", "Notch-signaling", "pathway", "Hes1", ",", "Hey1", ",", "and", "C1415525#ent", "<e2>", "become", "strongly", "up-regulated", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415525", "name": "C1415525#ent", "pos": [28, 29]}}
{"token": ["The", "C0015967#ent", "<e1>", "considerably", "lesser", "in", "elimination", "of", "these", "oscillations", "with", "ganglio-", "or", "C0242889#ent", "<e2>"], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [13, 14]}}
{"token": ["Later", "on", ",", "lack", "of", "C0003805#ent", "<e1>", "is", "responsible", "for", "sexual", "infantilism", "primary", "amenorrhea", "tall", "stature", "and", "C0032460#ent", "<e2>", "even", "in", "preadolescent", "girls", "."], "h": {"id": "C0003805", "name": "C0003805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [17, 18]}}
{"token": ["The", "increase", "in", "C1366587#ent", "<e1>", "correlates", "with", "a", "reduced", "extent", "of", "apoptotic", "cell", "death", "induced", "by", "C0015133#ent", "<e2>", "or", "the", "calcium", "ionophore", "A23187", "."], "h": {"id": "C1366587", "name": "C1366587#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [16, 17]}}
{"token": ["C1366587#ent", "<e1>", "decreased", "the", "caspase", "3", "induced", "by", "exposure", "to", "C0015133#ent", "<e2>", "and", "increased", "the", "viability", "of", "the", "transfected", "cells", "after", "C0015133#ent", "<e2>", "exposure", "."], "h": {"id": "C1366587", "name": "C1366587#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [10, 11]}}
{"token": ["6", "A", "poor", "pharmacodynamic", "response", "a", "reduced", "C0006376#ent", "<e1>", "excretion", "rate", "were", "observed", "for", "the", "patients", "with", "C0022661#ent", "<e2>", "whereas", "with", "hepatic", "disease", "C0006376#ent", "<e1>", "excretion", "rates", "were", "observed", "with", "an", "impaired", "diuretic", "response"], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0006376", "name": "C0006376#ent", "pos": [7, 8]}}
{"token": ["The", "assessment", "of", "treatment", "was", "based", "on", "clinical", "signs", "symptoms", "primarily", "in", "infections", "of", "lower", "respiratory", "tract", "C2827407#ent", "<e1>", "whereas", "in", "patients", "with", "pharyngotonsillitis", "and", "C0242147#ent", "<e2>", "bacteriological", "findings", "the", "main", "evaluation", "criteria"], "h": {"id": "C2827407", "name": "C2827407#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0242147", "name": "C0242147#ent", "pos": [25, 26]}}
{"token": ["Southern", "blot", "analysis", "two", "positional", "candidate", "genes", "C0086661#ent", "<e1>", "at", "8q24", ",", "and", "C0808901#ent", "<e2>", "at", "22q12", ",", "showed", "no", "genomic", "rearrangement"], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0808901", "name": "C0808901#ent", "pos": [13, 14]}}
{"token": ["Random-source", "dogs", "are", "susceptible", "to", "these", "C0012634#ent", "<e1>", "because", "of", "their", "increased", "risk", "of", "C3179011#ent", "<e2>", "exposure", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3179011", "name": "C3179011#ent", "pos": [14, 15]}}
{"token": ["Contrary", "to", "C0042974#ent", "<e1>", "vWd", ")", ",", "pseudo-vWd", "and", "C3538937#ent", "<e2>", "vWd", ",", "the", "patients", "did", "not", "show", "any", "increased", "binding", "of", "factor", "VIII/vWf", "to", "platelets", "in", "the", "presence", "of", "ristocetin", "."], "h": {"id": "C0042974", "name": "C0042974#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3538937", "name": "C3538937#ent", "pos": [9, 10]}}
{"token": ["C0162566#ent", "<e1>", "f-PCT", ")", "results", "from", "the", "half-normal", "activity", "of", "C1421374#ent", "<e2>", "URO-D", ")", "."], "h": {"id": "C0162566", "name": "C0162566#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1421374", "name": "C1421374#ent", "pos": [10, 11]}}
{"token": ["After", "washout", "of", "C0280858#ent", "<e1>", "but", "while", "the", "calcium", "channels", "still", "blocked", ",", "C1417487#ent", "<e2>", "(", "1", "ng/ml", ")", "induced", "a", "steady-state", "current", "."], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [13, 14]}}
{"token": ["MDES2", "protein", "prefers", "C3541242#ent", "<e1>", "as", "a", "substrate", "to", "sphinganine", ",", "and", "exhibits", "C1539265#ent", "<e2>", "C-4", "hydroxylase", "activities", "."], "h": {"id": "C3541242", "name": "C3541242#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1539265", "name": "C1539265#ent", "pos": [13, 14]}}
{"token": ["A", "CT", "scan", "a", "mediastinal", "mass", "suggested", "C0040115#ent", "<e1>", "often", "complicates", "MG", "or", "C3831153#ent", "<e2>", "."], "h": {"id": "C0040115", "name": "C0040115#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [13, 14]}}
{"token": ["generated", "by", "the", "C0043317#ent", "<e1>", "the", "effect", "of", "hypertonicity", "on", "C1705323#ent", "<e2>", "expression", "and", "prostaglandin", "E(2)", "."], "h": {"id": "C0043317", "name": "C0043317#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "alterations", "in", "nerve", "growth", "factor", "NGF", ")", "and", "C1413557#ent", "<e1>", "CNTF", ")", "contents", "during", "treatment", "with", "C0095278#ent", "<e2>", ",", "an", "aldose", "reductase", "inhibitor", "ARI", ")", ",", "on", "streptozotocin", "(STZ)-induced", "diabetic", "neuropathy", "rats", "."], "h": {"id": "C1413557", "name": "C1413557#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0095278", "name": "C0095278#ent", "pos": [18, 19]}}
{"token": ["SP", "activity", "was", "significantly", "reduced", "in", "tissues", "pretreated", "with", "the", "muscarinic", "cholinoceptor", "blocker", "C0004259#ent", "<e1>", "or", "the", "eicosanoid", "synthesis", "C0000546#ent", "<e2>"], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0000546", "name": "C0000546#ent", "pos": [19, 20]}}
{"token": ["However", ",", "atrial", "fibrillation", "AF", ")", "was", "induced", "by", "stimulation", "after", "C0086303#ent", "<e1>", "in", "2", "patients", "without", "C1706586#ent", "<e2>", "in", "the", "baseline", "study", "."], "h": {"id": "C0086303", "name": "C0086303#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [17, 18]}}
{"token": ["Of", "all", "the", "features", "of", "the", "C1848862#ent", "<e1>", ",", "hypertension", "and", "C0085207#ent", "<e2>", "the", "classic", "clinical", "manifestations"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085207", "name": "C0085207#ent", "pos": [11, 12]}}
{"token": ["C0003693#ent", "<e1>", "(", "5-LO", ")", "catalysis", "is", "positively", "regulated", "by", "C1413043#ent", "<e2>", "+", "ions", "and", "phospholipids", "that", "both", "act", "via", "the", "N-terminal", "C2-like", "domain", "of", "5-LO", "."], "h": {"id": "C0003693", "name": "C0003693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [10, 11]}}
{"token": ["Virus", "production", "significantly", "increased", "by", "culturing", "C0066350#ent", "<e1>", "on", "plasticware", "previously", "coated", "with", "C0009325#ent", "<e2>"], "h": {"id": "C0066350", "name": "C0066350#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "C1418444#ent", "<e1>", "(", "170", "microg/ml", ")", "stimulated", "the", "expression", "of", "C3888272#ent", "<e2>", "ASS", ")", "protein", "."], "h": {"id": "C1418444", "name": "C1418444#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3888272", "name": "C3888272#ent", "pos": [13, 14]}}
{"token": ["This", "organism", "was", "negative", "for", "C0007367#ent", "<e1>", ",", "indole", ",", "nitrate-reduction", "and", "C0005244#ent", "<e2>", "and", "failed", "to", "identify", "by", "Vitek", "ANI", "card", "bioMerieux", ",", "France", ")", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0005244", "name": "C0005244#ent", "pos": [12, 13]}}
{"token": ["Strains", "were", "tested", "for", "the", "production", "of", "C0007367#ent", "<e1>", "(", "ID", "Color", "test", ",", "bioMerieux", "sa", ")", "and", "C0005244#ent", "<e2>", "(", "Cefinase", ",", "BBL", ",", "Becton", "Dickinson", "USA", ")", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005244", "name": "C0005244#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "report", "the", "cloning", "of", "two", "mammalian", "InsP(6", ")", "C0031727#ent", "<e1>", "and", "a", "C1431526#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1431526", "name": "C1431526#ent", "pos": [15, 16]}}
{"token": ["The", "relative", "contribution", "of", "the", "two", "C1420870#ent", "<e1>", "TPH", ")", "isoforms", ",", "C1566598#ent", "<e2>", "and", "TPH2", ",", "to", "brain", "serotonergic", "system", "function", "is", "controversial", "."], "h": {"id": "C1420870", "name": "C1420870#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1566598", "name": "C1566598#ent", "pos": [12, 13]}}
{"token": ["This", "gene", "is", "predominantly", "expressed", "in", "the", "brain", "stem", "while", "the", "classical", "C1420870#ent", "<e1>", "now", "called", "C1566598#ent", "<e2>", ",", "is", "expressed", "in", "the", "gut", ",", "pineal", "gland", "spleen", ",", "and", "thymus", "."], "h": {"id": "C1420870", "name": "C1420870#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1566598", "name": "C1566598#ent", "pos": [16, 17]}}
{"token": ["C0221757#ent", "<e1>", "a", "recently", "identified", "C0019247#ent", "<e2>", "occurs", "almost", "as", "frequently", "as", "cystic", "fibrosis"], "h": {"id": "C0221757", "name": "C0221757#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [5, 6]}}
{"token": ["C0123053#ent", "<e1>", "reduces", "the", "number", "of", "these", "wavefronts", "and", "organizes", "C0004238#ent", "<e2>", "."], "h": {"id": "C0123053", "name": "C0123053#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [10, 11]}}
{"token": ["A", "recent", "linkage", "study", "C0040517#ent", "<e1>", "markers", "in", "the", "distal", "region", "chromosome", "2p", "a", "contradictory", "result", "with", "C1412131#ent", "<e2>", "ACP1", ")", "compared", "to", "the", "nearby", "anonymous", "DNA", "markers"], "h": {"id": "C0040517", "name": "C0040517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412131", "name": "C1412131#ent", "pos": [17, 18]}}
{"token": ["Our", "observation", "should", "be", "useful", "in", "understanding", "pathogenetic", "mechanisms", "of", "Chlamydia", "trachomatis-caused", "infections", "in", "humans", ",", "in", "particular", "those", "that", "produce", "C1290884#ent", "<e1>", "such", "as", "blinding", "trachoma", "C0080276#ent", "<e2>"], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0080276", "name": "C0080276#ent", "pos": [27, 28]}}
{"token": ["We", "performed", "systematic", "linkage", "analysis", "this", "family", ",", "and", "found", "tight", "linkage", "the", "C0277565#ent", "<e1>", "a", "polymorphic", "genetic", "marker", "locus", "(", "C0879468#ent", "<e2>", "or", "CSF1R", ")", "that", "has", "been", "physically", "mapped", "to", "chromosome", "5q33-q35"], "h": {"id": "C0277565", "name": "C0277565#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0879468", "name": "C0879468#ent", "pos": [21, 22]}}
{"token": ["The", "results", "suggest", "a", "role", "for", "sodium", "in", "amplifying", "the", "secretory", "response", "the", "increased", "entry", "of", "Ca2", "+", "obtained", "with", "the", "C0033036#ent", "<e1>", "of", "the", "beta-cells", "with", "C0017628#ent", "<e2>", "or", "HB", "699", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", "to", "their", "opposite", "effects", "on", "lipolysis", ",", "both", "C1705021#ent", "<e1>", "and", "EPI", "stimulate", "low-Km", "cyclic", "adenosine", "monophosphate", "cAMP", ")", "phosphodiesterase", "(", "C0031640#ent", "<e2>", ")", "in", "adipose", "tissue"], "h": {"id": "C1705021", "name": "C1705021#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [23, 24]}}
{"token": ["A", "case", "is", "reported", "of", "resistance", "to", "the", "muscle", "relaxing", "action", "of", "C0038627#ent", "<e1>", "due", "to", "the", "rare", "inherited", "condition", "of", "C0020443#ent", "<e2>", "."], "h": {"id": "C0038627", "name": "C0038627#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [21, 22]}}
{"token": ["We", "show", "that", "maternally", "provided", "C3537368#ent", "<e1>", "acts", "with", "C0027098#ent", "<e2>", "NMY-2", ")", "during", "embryonic", "polarity", "establishment", ",", "cytokinesis", "and", "germline", "cellularization"], "h": {"id": "C3537368", "name": "C3537368#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027098", "name": "C0027098#ent", "pos": [9, 10]}}
{"token": ["The", "facial", "appearance", "and", "some", "of", "the", "features", "resemble", "the", "C0878684#ent", "<e1>", "the", "name", "being", "an", "acronym", "for", "Short", "stature", "Hyperextensible", "joints", "Ocular", "depression", "C0265341#ent", "<e2>", "abnormalities", "of", "the", "Teeth", "."], "h": {"id": "C0878684", "name": "C0878684#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0265341", "name": "C0265341#ent", "pos": [24, 25]}}
{"token": ["The", "C0005064#ent", "<e1>", "nitrazepam", "and", "C0016375#ent", "<e2>", ",", "are", "less", "toxic", "in", "overdose", "and", "are", "relatively", "effective", "in", "treating", "insomnia", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0016375", "name": "C0016375#ent", "pos": [5, 6]}}
{"token": ["Additionally", ",", "the", "tissue", "proteoglycans", "that", "were", "not", "extracted", "by", "4", "M", "guanidine-HCl", "were", "solubilized", "by", "digestion", "of", "the", "tissue", "by", "C0030306#ent", "<e1>", "in", "the", "presence", "of", "C3653288#ent", "<e2>"], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3653288", "name": "C3653288#ent", "pos": [27, 28]}}
{"token": ["Among", "the", "20", "patients", "in", "the", "diflunisal", "group", "one", "developed", "diarrhoea", ",", "another", "C0563238#ent", "<e1>", ";", "in", "the", "C0030078#ent", "<e2>", "group", "one", "developed", "C0563238#ent", "<e1>", ",", "another", "herpetiform", "pustules", "."], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030078", "name": "C0030078#ent", "pos": [18, 19]}}
{"token": ["The", "current", "study", "examined", "the", "effect", "of", "blockade", "of", "the", "C1442521#ent", "<e1>", "axis", "with", "a", "GnRH", "antagonist", "C0103565#ent", "<e2>", ")", "on", "the", "neonatal", "population", "of", "Leydig", "cells", "the", "new", "world", "primate", "the", "common", "marmoset", "."], "h": {"id": "C1442521", "name": "C1442521#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0103565", "name": "C0103565#ent", "pos": [17, 18]}}
{"token": ["The", "translated", "peptide", "is", "80", "%", "C1334043#ent", "<e1>", "to", "rat", "pancreatic", "kallikrein", "75", "%", "homologous", "to", "rat", "C0087052#ent", "<e2>", "in", "the", "corresponding", "regions", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0087052", "name": "C0087052#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "immunocytochemical", "labeling", "C3494382#ent", "<e1>", "did", "not", "coincide", "with", "the", "localization", "of", "C0031727#ent", "<e2>", "mRNA", "previously", "observed", "by", "others", "using", "in", "situ", "hybridization"], "h": {"id": "C3494382", "name": "C3494382#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [13, 14]}}
{"token": ["Numerous", "reports", "suggest", "that", "C0162508#ent", "<e1>", "plays", "an", "important", "role", "in", "various", "C0012634#ent", "<e2>"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}}
{"token": ["Noxious", "C1413723#ent", "<e1>", "induced", "both", "C1706383#ent", "<e2>", "and", "c-Jun", "in", "the", "SPN", ",", "but", "not", "the", "IML", "."], "h": {"id": "C1413723", "name": "C1413723#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [5, 6]}}
{"token": ["To", "improve", "patient", "compliance", "with", "and", "acceptance", "of", "intravesical", "oxybutynin", "therapy", "for", "C0005697#ent", "<e1>", "developed", "a", "stable", "C0069805#ent", "<e2>", "solution", "that", "eliminates", "the", "complicated", "crushing", "procedure"], "h": {"id": "C0005697", "name": "C0005697#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0069805", "name": "C0069805#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "provide", "the", "first", "insight", "into", "the", "mechanisms", "controlling", "inducible", "transcription", "of", "the", "C0062505#ent", "<e1>", "and", "could", "represent", "an", "important", "lead", "into", "understanding", "how", "C1367469#ent", "<e2>", "expression", "is", "deregulated", "in", "metastatic", "tumor", "cells"], "h": {"id": "C0062505", "name": "C0062505#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [25, 26]}}
{"token": ["There", "are", "at", "least", "two", "groups", "of", "C0062505#ent", "<e1>", ":", "connective", "tissue-activating-peptide", "CTAP-III", ")", "and", "mammalian", "heparanase", "(", "C1367469#ent", "<e2>", ")", "."], "h": {"id": "C0062505", "name": "C0062505#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [18, 19]}}
{"token": ["Accidental", "injures", "suicide", ",", "tuberculosis", ",", "C0023890#ent", "<e1>", "alcoholism", ",", "pneumonia", ",", "bronchitis", ",", "C0747256#ent", "<e2>", "the", "most", "important", "sources", "of", "diseases", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [14, 15]}}
{"token": ["Reductions", "in", "C0916181#ent", "<e1>", "phospholamban", "were", "confined", "to", "the", "dysfunctional", "C0398738#ent", "<e2>", "region", "with", "no", "change", "in", "calsequestrin", "."], "h": {"id": "C0916181", "name": "C0916181#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0398738", "name": "C0398738#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", "to", "Form", "A", "Form", "B", "the", "C0163611#ent", "<e1>", ",", "which", "lacks", "the", "proposed", "C1414515#ent", "<e2>", "Form", "A", "can", "not", "be", "incorporated", "into", "liposomes", "."], "h": {"id": "C0163611", "name": "C0163611#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414515", "name": "C1414515#ent", "pos": [15, 16]}}
{"token": ["In", "vitro", "studies", "also", "suggest", "that", "C1418609#ent", "<e1>", "may", "possess", "important", "cell", "growth", "regulatory", "C0079427#ent", "<e2>", "properties", "."], "h": {"id": "C1418609", "name": "C1418609#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [14, 15]}}
{"token": ["The", "antihyperlipidaemic", "effect", "of", "C0032912#ent", "<e1>", "was", "less", "than", "that", "of", "C0391507#ent", "<e2>", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0391507", "name": "C0391507#ent", "pos": [11, 12]}}
{"token": ["C1413804#ent", "<e1>", "the", "reaction", "glutamine", "UTP", "+", "ATP", "--", ">", "C0017789#ent", "<e2>", "+", "CTP", "+", "ADP", "+", "Pi", "."], "h": {"id": "C1413804", "name": "C1413804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [10, 11]}}
{"token": ["The", "C2926735#ent", "<e1>", "of", "burning", "and", "C0677500#ent", "<e2>", "was", "also", "rated", "as", "longer", "lasting", "with", "metipranolol", "treatment", "than", "with", "levobunolol", "(", "Vistagan", ";", "Pharma-Allergan", ")", "treatment", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0677500", "name": "C0677500#ent", "pos": [6, 7]}}
{"token": ["In", "a", "four", "days", "old", "neonate", ",", "showing", "feeding", "difficulties", ",", "temperature", "imbalance", ",", "C0036572#ent", "<e1>", "and", "coma", ",", "C0175683#ent", "<e2>", "was", "diagnosed", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C0175683", "name": "C0175683#ent", "pos": [19, 20]}}
{"token": ["cDNA", "microarray", "analysis", "that", "engagement", "of", "C3539620#ent", "<e1>", "primarily", "suppressed", "the", "activation", "of", "NF-KB", "pathway", "NK", "cells", "up-regulated", "anti-inflammatory", "genes", "C0538674#ent", "<e2>", "IL-10", "."], "h": {"id": "C3539620", "name": "C3539620#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0538674", "name": "C0538674#ent", "pos": [20, 21]}}
{"token": ["The", "predicted", "C1305923#ent", "<e1>", "FbfA", "shows", "a", "homology", "of", "about", "30", "%", "to", "C1417932#ent", "<e2>", "of", "rhizobia", ",", "an", "N-acetylglucosamine-transferase", "which", "is", "involved", "in", "the", "synthesis", "of", "the", "sugar", "backbone", "lipo-oligosaccharides", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "plasma", "C1415521#ent", "<e1>", "levels", "were", "not", "elevated", "in", "101", "untreated", "patients", "with", "C0155583#ent", "<e2>"], "h": {"id": "C1415521", "name": "C1415521#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [15, 16]}}
{"token": ["C0757826#ent", "<e1>", "blocked", "the", "effect", "of", "C0067685#ent", "<e2>", ",", "but", "not", "of", "L-AP4", "or", "t-ACPD", ",", "on", "hypoxia-ischemia-stimulated", "cAMP", "elevation", "."], "h": {"id": "C0757826", "name": "C0757826#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0067685", "name": "C0067685#ent", "pos": [6, 7]}}
{"token": ["The", "relaxation", "induced", "by", "NaTC", "was", "inhibited", "by", "3',4'-dichlorobenzamil", ",", "a", "C0001645#ent", "<e1>", "of", "the", "C1420229#ent", "<e2>"], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420229", "name": "C1420229#ent", "pos": [15, 16]}}
{"token": ["The", "polyclonal", "antibody", "not", "C1413309#ent", "<e1>", "with", "human", "C3659502#ent", "<e2>", "an", "enzyme", "in", "the", "same", "aldo-keto", "reductase", "family", "and", "functionally", "related", "to", "aldose", "reductase"], "h": {"id": "C1413309", "name": "C1413309#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3659502", "name": "C3659502#ent", "pos": [8, 9]}}
{"token": ["A", "high", "incidence", "of", "C0010406#ent", "<e1>", "were", "found", "in", "C0035086#ent", "<e2>", "to", "be", "mediated", "by", "immune", "complexes"], "h": {"id": "C0010406", "name": "C0010406#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [9, 10]}}
{"token": ["Exogenous", "expression", "and", "short", "interfering", "depletion", "experiments", "demonstrate", "that", "C1537662#ent", "<e1>", "can", "be", "stabilized", "by", "both", "C1421409#ent", "<e2>", "and", "USP7", ",", "which", "deubiquitylate", "C1537662#ent", "<e1>", "in", "the", "cytosol", "and", "nucleus", ",", "respectively", "."], "h": {"id": "C1537662", "name": "C1537662#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421409", "name": "C1421409#ent", "pos": [16, 17]}}
{"token": ["It", "is", "considered", "that", "the", "eosinophilic", "granuloma", "soft", "tissue", "C0033838#ent", "<e1>", "is", "an", "C0012634#ent", "<e2>", "quite", "different", "from", "histiocytosis", "X."], "h": {"id": "C0033838", "name": "C0033838#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}}
{"token": ["Incubation", "of", "the", "30", "kDa", "protein", "with", "5", "mM", "C1705556#ent", "<e1>", "resulted", "in", "its", "resistance", "to", "C0163582#ent", "<e2>", "to", "trypsin", "treated", "with", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0163582", "name": "C0163582#ent", "pos": [16, 17]}}
{"token": ["The", "C1413231#ent", "<e1>", "was", "to", "determine", "if", "C0669372#ent", "<e2>", "iNOS", ")", "contributes", "to", "depressed", "cardiovascular", "function", "the", "acute", "phase", "streptozotocin-induced", "diabetes", "."], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [7, 8]}}
{"token": ["Arachidonic", "acid", "a", "C0031667#ent", "<e1>", "product", ",", "also", "increased", "C1623430#ent", "<e2>", "mRNA", "with", "a", "time", "course", "to", "that", "of", "hydrogen", "peroxide"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [9, 10]}}
{"token": ["A", "functional", "C0919550#ent", "<e1>", "required", "for", "the", "observed", "manganese", "repression", "of", "this", "C0029073#ent", "<e2>", "."], "h": {"id": "C0919550", "name": "C0919550#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [12, 13]}}
{"token": ["These", "doses", "are", "similar", "to", "C0003123#ent", "<e1>", "doses", "of", "C1413167#ent", "<e2>", ",", "a", "physiological", "peripheral", "satiety", "agent", "."], "h": {"id": "C0003123", "name": "C0003123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413167", "name": "C1413167#ent", "pos": [9, 10]}}
{"token": ["The", "C0114612#ent", "<e1>", "activity", "of", "GB1-C199A-MutY", "is", "comparable", "to", "that", "of", "the", "C2987364#ent", "<e2>", "enzyme", "."], "h": {"id": "C0114612", "name": "C0114612#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [12, 13]}}
{"token": ["The", "present", "study", "evaluates", "the", "efficacy", "of", "C0102130#ent", "<e1>", "in", "a", "group", "of", "the", "patients", "with", "C0242453#ent", "<e2>", "."], "h": {"id": "C0102130", "name": "C0102130#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242453", "name": "C0242453#ent", "pos": [16, 17]}}
{"token": ["The", "C0074722#ent", "<e1>", "are", "non-peptide", "compounds", "with", "varied", "structures", ";", "some", "(", "C0717550#ent", "<e2>", ",", "losartan", ",", "irbesartan", ",", "and", "valsartan", ")", "have", "a", "common", "tetrazolo-biphenyl", "structure", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0717550", "name": "C0717550#ent", "pos": [12, 13]}}
{"token": ["We", "wish", "to", "stress", "the", "importance", "of", "screening", "for", "C0035579#ent", "<e1>", ",", "particularly", "in", "those", "with", "C0006271#ent", "<e2>"], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0006271", "name": "C0006271#ent", "pos": [16, 17]}}
{"token": ["Eye", "findings", "C0338508#ent", "<e1>", "two", "patients", ",", "and", "C0035334#ent", "<e2>", "one", "."], "h": {"id": "C0338508", "name": "C0338508#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [8, 9]}}
{"token": ["Gastric", "acid", "by", "the", "parietal", "cells", "a", "significant", "role", "in", "a", "variety", "of", "C0017178#ent", "<e1>", "such", "as", "duodenal", "ulcer", "C0038358#ent", "<e2>", "and", "gastroesophageal", "reflux", "disease"], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [19, 20]}}
{"token": ["Among", "drugs", "recently", "introduced", "into", "Canada", "for", "treatment", "of", "C0017178#ent", "<e1>", "carbenoxolone", "sodium", "used", "in", "treating", "C0038358#ent", "<e2>", "and", "metoclopramide", "hydrochloride", "which", "modifies", "upper", "gastrointestinal", "tract", "motility", "."], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [16, 17]}}
{"token": ["A", "method", "for", "the", "analysis", "of", "several", "C3537143#ent", "<e1>", "and", "ionophore", "antibiotics", "well", "as", "C0076651#ent", "<e2>", "in", "liquid", "manure", "developed", "."], "h": {"id": "C3537143", "name": "C3537143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0076651", "name": "C0076651#ent", "pos": [14, 15]}}
{"token": ["The", "veins", ",", "but", "not", "the", "arteries", ",", "were", "more", "sensitive", "to", "clonidine", "and", "C0076890#ent", "<e1>", "than", "to", "C0031469#ent", "<e2>", "or", "methoxamine", "."], "h": {"id": "C0076890", "name": "C0076890#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [18, 19]}}
{"token": ["Of", "eight", "other", "drugs", "tested", ",", "chlorpromazine", ",", "C0031441#ent", "<e1>", "and", "four", "others", "were", "inactive", ",", "whereas", "phenelzine", "and", "C0065831#ent", "<e2>", "possessed", "activity.4", "."], "h": {"id": "C0031441", "name": "C0031441#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0065831", "name": "C0065831#ent", "pos": [19, 20]}}
{"token": ["A", "68-year-old", "man", "known", "to", "have", "C0238190#ent", "<e1>", "a", "cricopharyngeal", "myotomy", "an", "attempt", "to", "improve", "his", "progressive", "C0011168#ent", "<e2>", "."], "h": {"id": "C0238190", "name": "C0238190#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [17, 18]}}
{"token": ["This", "response", "was", "abolished", "by", "pretreatment", "with", "mast", "cell", "stabilizers", "cromoglycate", ",", "doxantrazole", ")", "and", "inhibitors", "of", "C0127400#ent", "<e1>", "diphenhydramine", ",", "metergoline", ",", "C0081408#ent", "<e2>", ")", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0081408", "name": "C0081408#ent", "pos": [23, 24]}}
{"token": ["They", "are", "characterized", "by", "C0020456#ent", "<e1>", "and", "hyperosmolarity", "in", "C0265354#ent", "<e2>", ",", "and", "by", "C0020456#ent", "<e1>", "and", "ketoacidosis", "in", "DKA", "with", "major", "electrolyte", "imbalance", ";", "both", "can", "co-exist", "."], "h": {"id": "C0265354", "name": "C0265354#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020456", "name": "C0020456#ent", "pos": [4, 5]}}
{"token": ["One", "potential", "common", "pathway", "linking", "C0005944#ent", "<e1>", "the", "pathogenesis", "of", "C1416377#ent", "<e2>", "is", "a", "thrombotic", "tendency", "due", "to", "dysregulation", "of", "haemostatic", "risk", "factors"], "h": {"id": "C0005944", "name": "C0005944#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416377", "name": "C1416377#ent", "pos": [10, 11]}}
{"token": ["Plasma", "activities", "the", "two", "main", "enkephalin", "degrading", "C3540790#ent", "<e1>", ",", "aminopeptidase", "and", "C3887624#ent", "<e2>", ",", "were", "similar", "in", "control", "and", "ANIT-treated", "rats", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [12, 13]}}
{"token": ["One", "of", "the", "major", "C3540790#ent", "<e1>", "for", "enkephalin", "degradation", "neutral", "endopeptidase", "enkephalinase", ",", "C3887624#ent", "<e2>", "MME", ")", "]", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [13, 14]}}
{"token": ["A", "limited", "number", "of", "C3540790#ent", "<e1>", "such", "as", "membrane", "metalloendopeptidase", "C3887624#ent", "<e2>", ")", "and", "angiotensin", "converting", "enzyme", "appear", "to", "be", "involved", "in", "deactivation", "and", "modulation", "of", "circulatory", "regulatory", "peptides"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [10, 11]}}
{"token": ["Inhibition", "of", "RhoA", "by", "the", "C3", "transferase", "Clostridium", "botulinum", "inhibited", "the", "LPA-induced", "C1333200#ent", "<e1>", "changes", "and", "prevented", "the", "LPA-induced", "C3889156#ent", "<e2>", "passage", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3889156", "name": "C3889156#ent", "pos": [19, 20]}}
{"token": ["Spinocerebellar", "ataxia", "types", "2", "SCA2", ")", "and", "3", "(", "SCA3", ")", "are", "autosomal-dominantly", "inherited", ",", "C0751870#ent", "<e1>", "by", "CAG", "repeat", "in", "the", "C0079941#ent", "<e2>", "the", "genes", "encoding", "ataxin-2", "and", "ataxin-3", ",", "respectively", "."], "h": {"id": "C0751870", "name": "C0751870#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [22, 23]}}
{"token": ["Overexpressing", "hTERT", "recovered", "telomerase", "activity", "not", "proliferation", ",", "whereas", "C0907533#ent", "<e1>", "expression", "of", "C0079068#ent", "<e2>", "recovered", "proliferation", "and", "hTERT", "expression", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [13, 14]}}
{"token": ["C1416611#ent", "<e1>", "currents", "were", "inhibited", "by", "C0076252#ent", "<e2>", "TEA", ")", "at", "1", "and", "10", "mM", "by", "39.5", "and", "48.4", "%", ",", "respectively", "."], "h": {"id": "C1416611", "name": "C1416611#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0076252", "name": "C0076252#ent", "pos": [6, 7]}}
{"token": ["In", "neonatal", "cardiomyocytes", ",", "interleukin-1beta", "and", "lipopolysaccharide", "(", "C2697656#ent", "<e1>", ")", "both", "stimulated", "C3813583#ent", "<e2>", "mRNA", "expression", "and", "increased", "C3813583#ent", "<e2>", "mRNA", "stability", "and", "protein", "synthesis", "failed", "to", "increase", "C3813583#ent", "<e2>", "mRNA", "transcription"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3813583", "name": "C3813583#ent", "pos": [13, 14]}}
{"token": ["We", "investigated", "whether", "polymorphisms", "in", "the", "candidate", "genes", "encoding", "solute", "carrier", "11a1", "protein", "SLC11A1", "formerly", "NRAMP1", ")", ",", "C0065661#ent", "<e1>", "MBL2", ")", "and", "Vitamin", "D", "receptor", "VDR", ")", "were", "associated", "with", "C0041296#ent", "<e2>", "in", "an", "East-African", "setting", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [31, 32]}}
{"token": ["Few", "studies", ",", "conducted", "in", "adult", "populations", ",", "have", "shown", "that", "genetically", "determined", "low", "C0065661#ent", "<e1>", "levels", "may", "confer", "partial", "protection", "against", "C0041296#ent", "<e2>", "(", "TB", ")", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [22, 23]}}
{"token": ["C1365493#ent", "<e1>", "may", "be", "a", "safer", "and", "cost-neutral", "alternative", "to", "C0354604#ent", "<e2>", "long-term", "treatment", "(", "secondary", "prophylaxis", "of", "venous", "thromboembolism"], "h": {"id": "C1365493", "name": "C1365493#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0354604", "name": "C0354604#ent", "pos": [10, 11]}}
{"token": ["C1824729#ent", "<e1>", "may", "present", "with", "features", "suggestive", "of", "C0085693#ent", "<e2>", "dengue-endemic", "areas", "."], "h": {"id": "C1824729", "name": "C1824729#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085693", "name": "C0085693#ent", "pos": [8, 9]}}
{"token": ["HRG", "also", "promotes", "interaction", "of", "C1417405#ent", "<e1>", "with", "endogenous", "ER", "and", "association", "of", "C1417405#ent", "<e1>", "or", "C1422386#ent", "<e1>", "with", "ERE-responsive", "target-gene", "promoters", "in", "vivo"], "h": {"id": "C1417405", "name": "C1417405#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422386", "name": "C1422386#ent", "pos": [16, 17]}}
{"token": ["The", "pattern", "of", "labeling", "seen", "after", "caudal", "area", "1", "-2", "and", "C1420622#ent", "<e1>", "injections", "differed", "only", "in", "its", "C1413096#ent", "<e2>", "--", "caudal", "extent", "within", "VPLm", "."], "h": {"id": "C1420622", "name": "C1420622#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [18, 19]}}
{"token": ["These", "include", "the", "human", "BLM", "gene", "whose", "mutation", "results", "in", "C0005859#ent", "<e1>", "and", "the", "human", "WRN", "gene", "whose", "mutation", "leads", "to", "C1337007#ent", "<e2>", "premature", "aging"], "h": {"id": "C0005859", "name": "C0005859#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1337007", "name": "C1337007#ent", "pos": [21, 22]}}
{"token": ["Concerning", "C0022917#ent", "<e1>", ",", "parietal", "cells", "a", "different", "activity", "of", "these", "C3540772#ent", "<e2>", "were", "observed", "both", "in", "starved", "and", "control", "animals"], "h": {"id": "C0022917", "name": "C0022917#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [11, 12]}}
{"token": ["Off", "'", "period", "C0013384#ent", "<e1>", "tend", "to", "be", "relatively", "fixed", ",", "C0239377#ent", "<e2>", ",", "and", "dystonic", "."], "h": {"id": "C0013384", "name": "C0013384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [11, 12]}}
{"token": ["In", "three", "patients", "with", "C0268307#ent", "<e1>", "carried", "the", "diagnosis", "of", "C0220991#ent", "<e2>", "99mTc-HIDA", "cholescintigraphy", "performed", "."], "h": {"id": "C0268307", "name": "C0268307#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0220991", "name": "C0220991#ent", "pos": [10, 11]}}
{"token": ["It", "was", "found", "that", "the", "C0214788#ent", "<e1>", "copurified", "with", "three", "isoenzymes", "of", "C0017837#ent", "<e2>", "had", "a", "pI", "of", "9.2", ",", "8.9", "and", "8.6", "respectively", "."], "h": {"id": "C0214788", "name": "C0214788#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [12, 13]}}
{"token": ["The", "physical", "treatments", "in", "the", "production", "of", "8Y", "seem", "to", "inactivate", "the", "agent(s", ")", "responsible", "for", "C0019196#ent", "<e1>", ",", "non-B", "hepatitis", "HIV", "transmission", "by", "transfusion", "of", "C1366370#ent", "<e2>", "been", "abolished", "."], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [26, 27]}}
{"token": ["No", "correlation", "was", "found", "between", "changes", "in", "the", "serum", "lipid", "concentrations", "changes", "in", "hsCRP", ",", "MCP-1", ",", "C1705527#ent", "<e1>", ",", "or", "fibrinogen", "in", "either", "the", "C2698196#ent", "<e2>", "or", "the", "no-drug", "group", "."], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2698196", "name": "C2698196#ent", "pos": [25, 26]}}
{"token": ["Specific", "binding", "of", "both", "a", "GABA", "C2987634#ent", "<e1>", "(", "[3H]muscimol", ")", "and", "an", "antagonist", "(", "C0005372#ent", "<e2>", ")", "was", "shown", "by", "membranes", "prepared", "from", "the", "cultures", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005372", "name": "C0005372#ent", "pos": [15, 16]}}
{"token": ["On", "the", "other", "hand", ",", "mutation", "of", "C2917660#ent", "<e1>", "within", "the", "amino-terminal", "phosphorylation", "domain", "abolished", "C0857836#ent", "<e2>", "DNA", "replication", "viability", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0857836", "name": "C0857836#ent", "pos": [15, 16]}}
{"token": ["Cells", "were", "then", "stimulated", "to", "proliferate", "by", "phytohaemagglutinin", "(", "C0030779#ent", "<e1>", ")", "under", "normal", "gravity", "and", "prematurely", "condensed", "chromosomes", "harvested", "after", "48", "h.", "C1366459#ent", "<e2>", "were", "scored", "in", "chromosomes", "1", "2", "by", "fluorescence", "in-situ", "hybridization"], "h": {"id": "C0030779", "name": "C0030779#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366459", "name": "C1366459#ent", "pos": [23, 24]}}
{"token": ["The", "serine", "protease", "C0040495#ent", "<e1>", "the", "induction", "of", "C1533698#ent", "<e2>", "by", "INF/LPS", ",", "by", "depleting", "intracellular", "thiol", "pools", "interfering", "with", "protein", "synthesis"], "h": {"id": "C0040495", "name": "C0040495#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [8, 9]}}
{"token": ["Statin", "also", "increased", "the", "C0030304#ent", "<e1>", "level", "of", "C3890018#ent", "<e2>", "60", "."], "h": {"id": "C0030304", "name": "C0030304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890018", "name": "C3890018#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "whether", "hydralazine", "might", "decrease", "DNA", "methyltransferase", "C0012873#ent", "<e1>", ")", "expression", "and", "induce", "autoimmunity", "by", "inhibiting", "extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e2>", ")", "pathway", "signaling", "."], "h": {"id": "C0012873", "name": "C0012873#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [20, 21]}}
{"token": ["Patients", "bearing", "no", "risk", "C0004153#ent", "<e1>", "showed", "in", "13", "%", "(", "C0042571#ent", "<e2>", ")", "and", "8", "%", "(", "hearing", "loss", "tinnitus", ")", "stenosis", "of", "the", "cervical", "arteries"], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042571", "name": "C0042571#ent", "pos": [11, 12]}}
{"token": ["Acute", "pharmacological", "inhibition", "of", "Janus", "kinase", "2", "signalling", "had", "no", "effect", "EPO", "C0242912#ent", "<e1>", ",", "whereas", "inhibition", "of", "C0089793#ent", "<e2>", "pathway", "abolished", "the", "protective", "effect", "EPO", "in", "both", "Stat5(+/+", ")", "and", "Stat5(-/-", ")", "neurons", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [18, 19]}}
{"token": ["The", "biochemical", "copurification", "and", "cytological", "colocalization", "of", "C1333891#ent", "<e1>", "and", "Polycomb", "group", "repressors", "strongly", "suggest", "that", "C1333891#ent", "<e1>", "is", "a", "component", "of", "the", "silencing", "complex", "chromatin", "modification", "specific", "regulatory", "regions", "C1335843#ent", "<e1>"], "h": {"id": "C1333891", "name": "C1333891#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335843", "name": "C1335843#ent", "pos": [30, 31]}}
{"token": ["Cadmium-induced", "overexpression", "of", "C1706384#ent", "<e1>", "at", "12", "h", "in", "the", "C0023899#ent", "<e2>", ",", "but", "not", "until", "96", "h", "in", "the", "testes", "and", "ventral", "prostate"], "h": {"id": "C1706384", "name": "C1706384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["Pro-inflammatory", "cytokines", "that", "increase", "the", "expression", "of", "type", "II", "NO", "synthase", "C1533698#ent", "<e1>", "or", "iNOS", ")", "decreased", "C1418929#ent", "<e2>", "expression", "in", "freshly", "isolated", ",", "non-passaged", "bovine", "aortic", "SMC", "."], "h": {"id": "C1533698", "name": "C1533698#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418929", "name": "C1418929#ent", "pos": [17, 18]}}
{"token": ["One", "patient", "developed", "a", "severe", "neutropenia", "and", "C0019360#ent", "<e1>", "another", "with", "an", "C0234533#ent", "<e2>", "tendency", "developed", "myoclonic", "jerks"], "h": {"id": "C0019360", "name": "C0019360#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [12, 13]}}
{"token": ["Adverse", "effects", "vitamin", "D", "deficiency", "the", "development", "of", "C0005940#ent", "<e1>", "however", ",", "other", "diseases", "such", "as", "multiple", "sclerosis", "type", "1", "diabetes", "C0003873#ent", "<e2>", "certain", "cancers", "have", "also", "been", "linked", "to", "vitamin", "D", "deficiency"], "h": {"id": "C0005940", "name": "C0005940#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [21, 22]}}
{"token": ["The", "ability", "of", "C0055673#ent", "<e1>", "to", "activate", "C0162745#ent", "<e2>", "suggests", "that", "C0055673#ent", "<e1>", "plays", "an", "active", "role", "in", "matrix", "degradation", "tissue", "sites", "mast", "cells", "with", "extracellular", "procollagenase", "."], "h": {"id": "C0055673", "name": "C0055673#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [7, 8]}}
{"token": ["To", "delineate", "the", "mechanism", "by", "which", "C1538124#ent", "<e1>", "acts", "in", "the", "C1173619#ent", "<e2>", "we", "analyzed", "mouse", "anti-Sep1", "monoclonal", "antibodies", "inhibition", "of", "the", "C1538124#ent", "<e1>", "in", "vitro", "activity", "."], "h": {"id": "C1538124", "name": "C1538124#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1173619", "name": "C1173619#ent", "pos": [11, 12]}}
{"token": ["Immunoblotting", "demonstrated", "that", "p42/44", "MAPK", "was", "phosphorylated", "and", "C0812234#ent", "<e1>", "increased", "in", "C0719022#ent", "<e2>", "TNF-alpha", "."], "h": {"id": "C0812234", "name": "C0812234#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0719022", "name": "C0719022#ent", "pos": [12, 13]}}
{"token": ["This", "was", "found", "both", "in", "joints", "with", "C0085435#ent", "<e1>", "in", "joints", "without", "clinical", "signs", "C0003864#ent", "<e2>", ",", "and", "in", "both", "seropositive", "and", "seronegative", "patients", "."], "h": {"id": "C0085435", "name": "C0085435#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [14, 15]}}
{"token": ["There", "were", "no", "morphologic", "changes", "when", "ethylenediaminetetracetate", "(", "EDTA", ")", "was", "used", "as", "an", "C0003280#ent", "<e1>", "or", "when", "plasma", "was", "substituted", "by", "isotonic", "saline", "acetar", ",", "C1412332#ent", "<e2>", "added", "acetar", "solution"], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [26, 27]}}
{"token": ["C0002874#ent", "<e1>", "AA", ")", "is", "a", "rare", "C3810350#ent", "<e2>", "treated", "either", "by", "immunosuppressive", "therapy", "allogeneic", "stem", "cell", "transplantation", "SCT", ")", "."], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3810350", "name": "C3810350#ent", "pos": [7, 8]}}
{"token": ["Immunocytochemical", "and", "immunoblotting", "techniques", "showed", "that", "the", "C1420261#ent", "<e1>", "level", "was", "not", "reduced", "significantly", "in", "the", "C0023522#ent", "<e2>", "mutant", "."], "h": {"id": "C1420261", "name": "C1420261#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023522", "name": "C0023522#ent", "pos": [16, 17]}}
{"token": ["The", "proposed", "methodology", "was", "applied", "to", "30", "normal", "subjects", "35", "patients", "with", "C0178879#ent", "<e1>", "acute", "and", "C0178879#ent", "<e1>", "hydronephrosis", "."], "h": {"id": "C0178879", "name": "C0178879#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0178879", "name": "C0178879#ent", "pos": [12, 13]}}
{"token": ["The", "two", "most", "common", "naturally", "occurring", "mutations", "in", "C1417057#ent", "<e1>", "result", "in", "substitution", "of", "C0815040#ent", "<e2>", "glycine", "residues", "in", "Gly-X-Y", "triplets", "on", "the", "N-terminal", "side", "of", "the", "hinge", "."], "h": {"id": "C1417057", "name": "C1417057#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [14, 15]}}
{"token": ["Upon", "reaction", "with", "C1412332#ent", "<e1>", ",", "apotransferrin", "or", "C0057985#ent", "<e2>", "at", "a", "1:1", "ratio", ",", "RAP", "rapidly", "binds", "to", "these", "proteins", "to", "produce", "substantially", "equivalent", "and", "relatively", "stable", "adducts", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0057985", "name": "C0057985#ent", "pos": [8, 9]}}
{"token": ["Hypoxia-inducible", "factor", "1", "HIF-1", ")", "is", "a", "basic", "helix-loop-helix", "protein", "activates", "transcription", "of", "C1704839#ent", "<e1>", "including", "those", "encoding", ":", "erythropoietin", ",", "vascular", "endothelial", "growth", "factor", "heme", "oxygenase-1", "C1533698#ent", "<e2>", "and", "the", "glycolytic", "enzymes", "aldolase", "A", "enolase", "1", "lactate", "dehydrogenase", "A", "phosphofructokinase", "I", "and", "phosphoglycerate", "kinase", "1"], "h": {"id": "C1704839", "name": "C1704839#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [27, 28]}}
{"token": ["A", "case", "of", "autoimmune", "polyglandular", "deficiency", "type", "II", "(", "C0001403#ent", "<e1>", "primary", "hypothyroidism", "primary", "hypogonadism", "a", "lengthy", "evolution", "and", "C1847835#ent", "<e2>", ")", ",", "associated", "with", "progressive", "sellar", "enlargement", "is", "presented", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1847835", "name": "C1847835#ent", "pos": [19, 20]}}
{"token": ["C0001403#ent", "<e1>", "chronic", "candidiasis", "the", "nails", "and", "C1847835#ent", "<e2>", "developed", "in", "adolescence", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1847835", "name": "C1847835#ent", "pos": [7, 8]}}
{"token": ["Our", "proband", "is", "a", "12-year-old", "boy", "with", "C0001403#ent", "<e1>", "insulin", "dependent", "diabetes", "mellitus", "IDDM", ")", ",", "and", "C1847835#ent", "<e2>", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1847835", "name": "C1847835#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "recently", "established", "that", "urate", "was", "reabsorbed", "via", "URAT1", "on", "the", "tubular", "apical", "membrane", "that", "mutations", "in", "C1420134#ent", "<e1>", "encoding", "URAT1", "cause", "C0473219#ent", "<e2>"], "h": {"id": "C1420134", "name": "C1420134#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0473219", "name": "C0473219#ent", "pos": [23, 24]}}
{"token": ["The", "G774A", "mutation", "in", "the", "C1420134#ent", "<e1>", "encoding", "URAT1", "predominates", "in", "Japanese", "C0473219#ent", "<e2>"], "h": {"id": "C1420134", "name": "C1420134#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0473219", "name": "C0473219#ent", "pos": [12, 13]}}
{"token": ["Considerable", "potentiation", "of", "the", "activity", "of", "C0034283#ent", "<e1>", "and", "to", "a", "somewhat", "less", "extent", "of", "proguanil", "by", "C1639494#ent", "<e2>", "has", "been", "demonstrated", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [17, 18]}}
{"token": ["We", "investigated", "the", "association", "between", "the", "Plasmodium", "vivax", "dihydrofolate", "reductase", "Pvdhfrtas", ")", "and", "the", "P.", "vivax", "dihydropteroate", "synthase", "Pvdhps", ")", "genotype", "and", "in", "vitro", "sensitivity", "to", "the", "C0034283#ent", "<e1>", "WR99210", ",", "chlorcycloguanil", ",", "sulfadoxine", ",", "and", "C1639494#ent", "<e2>", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1639494", "name": "C1639494#ent", "pos": [36, 37]}}
{"token": ["Switching", "to", "an", "equivalent", "dose", "of", "C0037982#ent", "<e1>", "from", "prior", "C0040615#ent", "<e2>", "associated", "with", "significant", "improvement", "in", "the", "negative", "symptoms", "of", "the", "positive", "and", "negative", "syndrome", "scale", "(", "PANSS", ")", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [10, 11]}}
{"token": ["Induction", "of", "jun", "and", "fos", "proteins", "C1305923#ent", "<e1>", "AP-1", ")", "are", "mediated", "via", "pathways", "involving", "C1259877#ent", "<e2>", "the", "protein", "kinase", "encoded", "by", "the", "raf", "proto-oncogene"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [15, 16]}}
{"token": ["The", "diagnosis", "of", "C3671878#ent", "<e1>", "established", "after", "a", "3-year", "course", "of", "clinically", "apparent", "C0392525#ent", "<e2>", ",", "characterised", "by", "stone", "passage"], "h": {"id": "C3671878", "name": "C3671878#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [13, 14]}}
{"token": ["The", "protein", "kinase", "inhibitors", "staurosporine", "and", "C0124355#ent", "<e1>", "effectively", "suppressed", "chitin-induced", "gene", "expression", ",", "while", "the", "protein", "phosphatase", "inhibitors", "C0054549#ent", "<e2>", "okadaic", "acid", "induced", "the", "accumulation", "of", "mRNA", "in", "the", "absence", "of", "chitin", "."], "h": {"id": "C0124355", "name": "C0124355#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0054549", "name": "C0054549#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "present", "evidence", "that", "C1421947#ent", "<e1>", "is", "a", "C0025517#ent", "<e2>", "is", "not", "associated", "with", "aberrant", "membrane", "fusion/fission", "."], "h": {"id": "C1421947", "name": "C1421947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}}
{"token": ["Two", "of", "five", "patients", "with", "ANA", "and", "rheumatoid", "factor", "C0085084#ent", "<e1>", "such", "as", "C0027697#ent", "<e2>", "and", "Raynaud's", "phenomenon", "."], "h": {"id": "C0085084", "name": "C0085084#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027697", "name": "C0027697#ent", "pos": [13, 14]}}
{"token": ["HCl", "(", "1", "N", ")", "led", "to", "a", "significant", "increase", "in", "bronchoconstriction", "and", "plasma", "extravasation", "the", "main", "C0006267#ent", "<e1>", "and", "trachea", "of", "rabbits", "pretreated", "with", "C0033497#ent", "<e2>", ",", "atropine", "and", "phosphoramidon", "."], "h": {"id": "C0006267", "name": "C0006267#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "the", "sequence", "surrounding", "threonine", "97", "bovine", "C2347054#ent", "<e1>", "may", "contain", "essential", "features", "of", "a", "recognition", "sequence", "C0170168#ent", "<e2>"], "h": {"id": "C2347054", "name": "C2347054#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [18, 19]}}
{"token": ["Two", "cytosolic", "forms", "quinone", "oxidoreductases", "NAD(P)H", ":", "quinone", "oxidoreductase", "1", "C0919428#ent", "<e1>", ")", "and", "NRH", ":", "C0027280#ent", "<e2>", "NQO2", ")", "]", "were", "previously", "identified", ",", "purified", ",", "and", "cloned", "."], "h": {"id": "C0919428", "name": "C0919428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027280", "name": "C0027280#ent", "pos": [16, 17]}}
{"token": ["Cultured", "brain", "cells", "metabolized", "both", "T4", "and", "T3", "by", "C0014442#ent", "<e1>", "catalyzed", "deiodination", "reactions", "increase", "(", "type", "II", "5'-deiodinase", "or", "decrease", "(", "C0669524#ent", "<e2>", "type", "III", "5-deiodinase", ")", "the", "bioactivity", "of", "thyroid", "hormone"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669524", "name": "C0669524#ent", "pos": [22, 23]}}
{"token": ["To", "further", "characterize", "C1419227#ent", "<e1>", ",", "a", "pGBrac1", "expression", "vector", "of", "PCR-amplified", "Brac1", "cDNA", "plus", "C1415329#ent", "<e2>", "GST", ")", "and", "pBKS(+)II", "was", "used", "to", "purify", "the", "protein", "."], "h": {"id": "C1419227", "name": "C1419227#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415329", "name": "C1415329#ent", "pos": [15, 16]}}
{"token": ["C0162745#ent", "<e1>", "from", "human", "polymorphonuclear", "leukocytes", "C1721358#ent", "<e2>", "attacks", "collagen", "type", "II", "solution", "at", "a", "rate", "intermediate", "to", "those", "of", "type", "I", "III", "collagens"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1721358", "name": "C1721358#ent", "pos": [6, 7]}}
{"token": ["Plasma", "samples", "were", "assayed", "for", "C0008783#ent", "<e1>", ",", "and", "nefazodone", "and", "its", "metabolites", "hydroxynefazodone", "and", "C0044170#ent", "<e2>", "by", "specific", ",", "validated", "h.p.l.c", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0044170", "name": "C0044170#ent", "pos": [15, 16]}}
{"token": ["There", "were", "no", "patients", "with", "deficiency", "of", "protein", "C", "protein", "S.", "had", "resistance", "to", "C1170000#ent", "<e1>", "C0033036#ent", "<e2>", ")", "and", "one", "had", "C0033036#ent", "<e2>", "resistance", "associated", "with", "antithrombin", "deficiency"], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [16, 17]}}
{"token": ["A", "coagulation", "test", ",", "termed", "C1170000#ent", "<e1>", "APC", ")", "resistance", ",", "involving", "poor", "anticoagulant", "response", "C0033036#ent", "<e2>", "is", "currently", "the", "most", "common", "laboratory", "finding", "among", "venous", "thrombophilic", "patients", "."], "h": {"id": "C1170000", "name": "C1170000#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [15, 16]}}
{"token": ["This", "stimulated", "C1705594#ent", "<e1>", "release", "was", "enhanced", "by", "the", "cyclooxygenase", "inhibitors", "indomethacin", ",", "C0020740#ent", "<e2>", ",", "and", "aspirin", "at", "micromolar", "concentrations", ",", "but", "inhibited", "in", "a", "dose-dependent", "manner", "by", "prostaglandin", "E2", "PGE2", ")", "."], "h": {"id": "C1705594", "name": "C1705594#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [13, 14]}}
{"token": ["Hepatocyte", "growth", "factor", "activator", "inhibitor", "type", "1", "is", "a", "membrane-bound", "protease", "inhibitor", "is", "thought", "to", "regulate", "the", "activities", "of", "C0215993#ent", "<e1>", "matriptase", ",", "hepsin", ",", "and", "C2745880#ent", "<e2>", "."], "h": {"id": "C0215993", "name": "C0215993#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2745880", "name": "C2745880#ent", "pos": [26, 27]}}
{"token": ["C0008533#ent", "<e1>", "a", "rare", "form", "of", "C0008533#ent", "<e1>", "which", "patients", "experience", "spontaneous", "postpubertal", "recovery", "of", "factor", "IX", "levels", "."], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [0, 1]}}
{"token": ["Here", ",", "the", "antigenicity", "of", "the", "streptococcal", "collagen-like", "(", "CL", ")", "proteins", ",", "Scl1", "and", "C1336564#ent", "<e1>", ",", "that", "exhibit", "structural", "similarity", "to", "human", "C0009325#ent", "<e2>", ",", "was", "analyzed", "."], "h": {"id": "C1336564", "name": "C1336564#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [24, 25]}}
{"token": ["However", ",", "C3152216#ent", "<e1>", "interaction", "with", "CBP", "through", "the", "C1334867#ent", "<e2>", "CBP", "interaction", "domain", "CID", ")", "is", "essential", "for", "transformation", "."], "h": {"id": "C3152216", "name": "C3152216#ent", "pos": [2, 3]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1334867", "name": "C1334867#ent", "pos": [9, 10]}}
{"token": ["To", "identify", "residues", "involved", "in", "the", "C1707164#ent", "<e1>", "substrate-specific", "channel", "activity", "we", "devised", "a", "selection", "scheme", "C1875400#ent", "<e2>", "albicidin-resistant", "tsx", "mutants", "synthesizing", "Tsx", "proteins", "with", "defects", "in", "their", "nucleoside", "uptake", "function", "."], "h": {"id": "C1707164", "name": "C1707164#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [16, 17]}}
{"token": ["We", "show", "that", "the", "protein", "level", "RelB", "is", "significantly", "reduced", "in", "the", "absence", "of", "C1822796#ent", "<e1>", "and", "reduced", "even", "more", "when", "both", "C1822796#ent", "<e1>", "and", "C2986464#ent", "<e1>", "are", "absent", "."], "h": {"id": "C1822796", "name": "C1822796#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [25, 26]}}
{"token": ["Our", "genetic", "evidence", "that", "C1822796#ent", "<e1>", "is", "required", "and", "sufficient", "as", "a", "fourth", "IkappaB", "protein", "noncanonical", "C2986464#ent", "<e2>", "of", "NIK", "and", "IKK1", "."], "h": {"id": "C1822796", "name": "C1822796#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [16, 17]}}
{"token": ["An", "unusual", "case", "of", "C0019372#ent", "<e1>", "presenting", "with", "C1535939#ent", "<e2>", "and", "pleural", "effusions", "described", "."], "h": {"id": "C0019372", "name": "C0019372#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [8, 9]}}
{"token": ["Many", "current", "C0360390#ent", "<e1>", "require", "some", "form", "of", "cellular", "activation", "e.g.", "the", "activation", "of", "C0022209#ent", "<e2>", "by", "a", "catalase-peroxidase", ")", "."], "h": {"id": "C0360390", "name": "C0360390#ent", "pos": [2, 3]}, "relation": "therapeutic_class_of", "t": {"id": "C0022209", "name": "C0022209#ent", "pos": [14, 15]}}
{"token": ["Fifty-four", "patients", "with", "C0019202#ent", "<e1>", "studied", "with", "regard", "to", "C0022650#ent", "<e2>"], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [9, 10]}}
{"token": ["The", "C0521942#ent", "<e1>", "1-sarcosine", ",", "8-isoleucine", "angiotensin", "II", "infused", "in", "two", "patients", "with", "untreated", "C0001403#ent", "<e2>"], "h": {"id": "C0521942", "name": "C0521942#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [14, 15]}}
{"token": ["This", "injury", "was", "inhibited", "by", "C0033607#ent", "<e1>", "but", "not", "by", "catalase", "or", "C0038838#ent", "<e2>"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [12, 13]}}
{"token": ["T", "lymphocytes", "in", "PBMCs", "and", "isolated", "CD4+", "T", "lymphocytes", "stimulated", "with", "phorbol-12-myristate-13-acetate", "and", "C0022020#ent", "<e1>", "also", "induced", "C1417162#ent", "<e2>", "expression", "as", "assessed", "by", "Western", "blot", "but", "only", "low", "levels", "were", "expressed", "at", "the", "cell", "surface"], "h": {"id": "C0022020", "name": "C0022020#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417162", "name": "C1417162#ent", "pos": [17, 18]}}
{"token": ["C0011991#ent", "<e1>", "the", "form", "of", "C0017160#ent", "<e2>", "to", "the", "deaths", "of", "more", "children", "than", "any", "other", "single", "condition", "in", "the", "world", "."], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0017160", "name": "C0017160#ent", "pos": [5, 6]}}
{"token": ["Non-immunized/challenged", "intact", "and", "C1416746#ent", "<e1>", "vaginal", "infection", "succumbed", "to", "C0752235#ent", "<e2>", "while", "immunized/challenged", "mice", "exhibited", "reduced", "or", "no", "vaginal", "infection", "no", "neurological", "disease"], "h": {"id": "C1416746", "name": "C1416746#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [9, 10]}}
{"token": ["A", "peptidyl-prolyl", "cis/trans", "isomerase", "C1826563#ent", "<e1>", "is", "involved", "in", "many", "cellular", "events", "such", "as", "C1539078#ent", "<e2>", "cell", "proliferation", "and", "differentiation", "through", "isomerizing", "prophosphorylated", "substrates", "."], "h": {"id": "C1826563", "name": "C1826563#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [14, 15]}}
{"token": ["The", "combination", "of", "AII", "injection", "and", "amiloride", "addition", "to", "the", "salt", "solution", "increased", "C3273505#ent", "<e1>", "initiation", "but", "C3273505#ent", "<e1>", "C2926735#ent", "<e1>", "was", "short", "and", "water", "loss", "prevented", "."], "h": {"id": "C3273505", "name": "C3273505#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [19, 20]}}
{"token": ["The", "same", "concentration", "of", "C0018549#ent", "<e1>", "has", "no", "effect", "the", "water", "permeability", "human", "red", "cells", "after", "maximal", "C0008249#ent", "<e2>", "inhibition", "."], "h": {"id": "C0018549", "name": "C0018549#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008249", "name": "C0008249#ent", "pos": [17, 18]}}
{"token": ["C0036572#ent", "<e1>", "during", "six", "months", "of", "C0009008#ent", "<e2>", "citrate", "therapy", "a", "36-year-old", "man", "who", "had", "hypogonadotropic", "hypogonadism", "reproductive", "dysfunction", "and", "a", "16-year", "history", "of", "regular", "seizures", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009008", "name": "C0009008#ent", "pos": [6, 7]}}
{"token": ["Since", "the", "gene", "for", "C0037875#ent", "<e1>", "immediately", "upstream", "of", "the", "homologous", "human", "C0140145#ent", "<e2>", ",", "we", "compared", "the", "effects", "of", "Gy", "and", "Hyp", "mutations", "both", "the", "spermine", "synthase", "gene", "the", "Pex", "gene"], "h": {"id": "C0037875", "name": "C0037875#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [12, 13]}}
{"token": ["Evidence-based", "guidelines", "C3540047#ent", "<e1>", "for", "the", "treatment", "of", "patients", "with", "cases", "of", "C0520575#ent", "<e2>", "or", "bacterial", "prostatitis", "severe", "enough", "to", "warrant", "hospitalization", "."], "h": {"id": "C3540047", "name": "C3540047#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0520575", "name": "C0520575#ent", "pos": [12, 13]}}
{"token": ["Each", "SCD", "C0597298#ent", "<e1>", "was", "able", "to", "complement", "the", "C1418729#ent", "<e2>", "mutation", "in", "Saccharomyces", "cerevisiae", "heterologous", "expression", "of", "transgenic", "SCD", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418729", "name": "C1418729#ent", "pos": [9, 10]}}
{"token": ["Double", "staining", "tumour", "tissue", "co-expression", "of", "C2698456#ent", "<e1>", "and", "C1826396#ent", "<e2>", "in", "cells", "of", "gangliocytomas", "and", "gangliogliomas", "and", "co-expression", "of", "C2698456#ent", "<e1>", "with", "S100", "protein", "GFAP", "in", "glial", "tumours", "respectively", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2698456", "name": "C2698456#ent", "pos": [6, 7]}}
{"token": ["To", "determine", "the", "pretreatment", "factors", "associated", "with", "undetectable", "C1366489#ent", "<e1>", "PSA", ")", "nadir", "after", "8", "months", "of", "androgen", "suppression", "therapy", "C1420113#ent", "<e2>", ")", "."], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420113", "name": "C1420113#ent", "pos": [20, 21]}}
{"token": ["Thirty-nine", "children", "(", "28", "with", "isolated", "GHD", "[", "C1415935#ent", "<e1>", "]", "and", "11", "with", "C0020635#ent", "<e2>", "MPHD", "]", ")", "were", "investigated", "to", "show", "the", "effects", "of", "C1415935#ent", "<e1>", "vs", "MPHD", "on", "bone", "status"], "h": {"id": "C1415935", "name": "C1415935#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020635", "name": "C0020635#ent", "pos": [14, 15]}}
{"token": ["C1862939#ent", "<e1>", "ALS", ")", "was", "first", "described", "by", "C0003892#ent", "<e2>", "in", "1869", "as", "what", "we", "would", "now", "call", "a", "sporadic", "disease-a", "disease", "to", "occur", "without", "a", "strong", "genetic", "influence"], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003892", "name": "C0003892#ent", "pos": [8, 9]}}
{"token": ["Now", "we", "report", "that", "MAPK", "activation", "by", "exogenous", "C0538269#ent", "<e1>", "depends", "on", "C0139905#ent", "<e2>", "activation", "."], "h": {"id": "C0538269", "name": "C0538269#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0139905", "name": "C0139905#ent", "pos": [12, 13]}}
{"token": ["C1417956#ent", "<e1>", "was", "effectively", "solubilized", "from", "bovine", "P2", "membranes", "by", "C0136864#ent", "<e2>", "PI-PLC", ")", ",", "indicating", "that", "C1417956#ent", "<e1>", "is", "a", "glycosylphosphatidylinositol", "(GPI)-anchored", "protein"], "h": {"id": "C1417956", "name": "C1417956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0136864", "name": "C0136864#ent", "pos": [10, 11]}}
{"token": ["Itraconazole", "strongly", "interacts", "with", "some", "drugs", "metabolized", "by", "C1142644#ent", "<e1>", "for", "example", ",", "C0015772#ent", "<e2>", "and", "lovastatin", ",", "by", "inhibiting", "their", "metabolism", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [8, 9]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [13, 14]}}
{"token": ["The", "clinical", "features", ",", "however", ",", "were", "distinctive", "in", "that", "in", "addition", "to", "the", "lung", "involvement", "there", "was", "alopecia", ",", "digital", "vasculitic", "ulcers", "C0034734#ent", "<e1>", "phenomenon", ",", "polyarthritis", ",", "and", "C0151786#ent", "<e2>"], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0151786", "name": "C0151786#ent", "pos": [30, 31]}}
{"token": ["Since", "the", "depolarisations", "evoked", "by", "C1705518#ent", "<e1>", "were", "not", "attenuated", "by", "either", "tetrodotoxin", "or", "C0022816#ent", "<e2>", "direct", "excitatory", "action", "of", "C1705518#ent", "<e1>", "is", "postulated", "."], "h": {"id": "C0022816", "name": "C0022816#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705518", "name": "C1705518#ent", "pos": [5, 6]}}
{"token": ["Since", "N-formyl-Met-Leu-Phe", ",", "platelet-activating", "factor", "and", "leukotriene", "(", "LT", ")", "C1705085#ent", "<e1>", "have", "these", "same", "bioactions", ",", "receptors", "for", "the", "latter", "C0035064#ent", "<e2>", "might", "mediate", "responses", "to", "5-HETE", "."], "h": {"id": "C1705085", "name": "C1705085#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "we", "show", "that", "four", "mitogen-activated", "protein", "MAP", ")", "kinase", "pathways", "activated", "in", "LPS-stimulated", "macrophages", ":", "the", "C4082284#ent", "<e1>", "ERK", ")", ",", "c-Jun", "N-terminal", "kinase/stress-activated", "protein", "kinase", "p38", ",", "and", "C1174318#ent", "<e2>", "pathways", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1174318", "name": "C1174318#ent", "pos": [33, 34]}}
{"token": ["6", ")", "C1533491#ent", "<e1>", ",", "like", "gefitinib", ",", "is", "C0025517#ent", "<e2>", "by", "the", "cytochrome", "P450", "isoenzyme", "CYP3A4", ",", "potentially", "creating", "a", "high", "risk", "of", "interactions", "."], "h": {"id": "C1533491", "name": "C1533491#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}}
{"token": ["Two", "compounds", "identified", "in", "the", "screen", ",", "caffeic", "acid", "phenethyl", "ester", "a", "major", "active", "component", "honeybee", "propolis", ",", "and", "the", "C0949665#ent", "<e1>", "agent", "enoxacin", "exhibited", "antifungal", "activity", "a", "murine", "model", "of", "C0006849#ent", "<e2>", "."], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0006849", "name": "C0006849#ent", "pos": [31, 32]}}
{"token": ["The", "vasoconstrictor", "response", "C0021246#ent", "<e1>", "was", "not", "altered", "by", "meclofenamate", "and", "C0031441#ent", "<e2>", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031441", "name": "C0031441#ent", "pos": [11, 12]}}
{"token": ["Co-expression", "of", "CCR2B", "in", "Xenopus", "oocytes", "beta-adrenergic", "receptor", "kinase", "2", "C2346566#ent", "<e1>", ",", "but", "not", "beta", "ark1", "C1384522#ent", "<e2>", "specifically", "blocked", "receptor", "activation", "MCP-1", "."], "h": {"id": "C2346566", "name": "C2346566#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1384522", "name": "C1384522#ent", "pos": [17, 18]}}
{"token": ["C0724560#ent", "<e1>", "lotion", "demonstrates", "multiple", "anti-inflammatory", "properties", "known", "effects", "on", "arachidonic", "acid", "C1744635#ent", "<e2>", "tumour", "necrosis", "factor-alpha", "pathways", "along", "with", "an", "excellent", "side-effect", "profile", "."], "h": {"id": "C0724560", "name": "C0724560#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1744635", "name": "C1744635#ent", "pos": [12, 13]}}
{"token": ["Human", "multidrug", "resistance", "protein", "2", "C1412077#ent", "<e1>", ",", "encoded", "by", "C3540577#ent", "<e2>", ")", "is", "involved", "in", "active", "efflux", "anionic", "drugs", "as", "methotrexate", "."], "h": {"id": "C1412077", "name": "C1412077#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3540577", "name": "C3540577#ent", "pos": [10, 11]}}
{"token": ["The", "most", "active", "of", "these", ",", "C0766412#ent", "<e1>", ",", "is", "very", "similar", "to", "C0388976#ent", "<e2>", "regard", "to", "in", "vitro", "potency", "and", "mode", "of", "action", "across", "a", "variety", "of", "cell", "types"], "h": {"id": "C0766412", "name": "C0766412#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0388976", "name": "C0388976#ent", "pos": [13, 14]}}
{"token": ["C0766412#ent", "<e1>", "is", "more", "readily", "synthesized", "and", "more", "stable", "than", "C0388976#ent", "<e2>", "which", "is", "currently", "undergoing", "clinical", "trials"], "h": {"id": "C0766412", "name": "C0766412#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0388976", "name": "C0388976#ent", "pos": [10, 11]}}
{"token": ["In", "malignant", "mesothelioma", "gastric", "cancer", "C1419285#ent", "<e1>", "methylation", "is", "associated", "with", "virus", "infection", "C1456377#ent", "<e2>", "and", "EBV", ",", "respectively", ",", "and", "suggests", "a", "causal", "relationship", "between", "viral", "infection", "progressive", "C1419285#ent", "<e1>", "methylation", "in", "carcinogenesis", "."], "h": {"id": "C1419285", "name": "C1419285#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "C1833640#ent", "<e1>", "failed", "to", "stimulate", "transcription", "from", "the", "C1420709#ent", "<e2>", "blocked", "the", "synergistic", "stimulation", "this", "promoter", "by", "wild-type", "PAX8", "and", "thyroid", "transcription", "factor-1"], "h": {"id": "C1833640", "name": "C1833640#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "co-treatment", "with", "C0028978#ent", "<e1>", "causes", "a", "minor", "increase", "in", "the", "absorption", "of", "C0025132#ent", "<e2>"], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025132", "name": "C0025132#ent", "pos": [16, 17]}}
{"token": ["The", "development", "of", "structural", "analogues", "of", "capsazepine", "may", "yield", "compounds", "that", "could", "selectively", "inhibit", "C1956068#ent", "<e1>", "prove", "useful", "for", "the", "treatment", "of", "C0042075#ent", "<e2>", "a", "role", "for", "C1956068#ent", "<e1>", "been", "described", "."], "h": {"id": "C1956068", "name": "C1956068#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [22, 23]}}
{"token": ["The", "differential", "expression", "of", "individual", "IFN-A", "C0017337#ent", "<e1>", "is", "modulated", "by", "the", "specific", "transcription", "activators", "IFN", "regulatory", "factor", "3", "C1334139#ent", "<e2>", ")", "and", "IRF-7", "and", "the", "homeoprotein", "transcription", "repressor", "Pitx1", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334139", "name": "C1334139#ent", "pos": [19, 20]}}
{"token": ["We", "demonstrate", "that", "an", "C1336575#ent", "<e1>", "and", "NF-kappaB", "interaction", "exists", "but", "does", "not", "prevent", "C2986464#ent", "<e2>", "nuclear", "translocation", "or", "DNA", "binding"], "h": {"id": "C1336575", "name": "C1336575#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [14, 15]}}
{"token": ["Expression", "of", "C1739091#ent", "<e1>", "is", "required", "for", "optimal", "C1705526#ent", "<e2>", "activation", "after", "cellular", "exposure", "to", "genotoxic", "stress", "and", "depletion", "of", "C1739091#ent", "<e1>", "leads", "to", "spontaneous", "DNA", "damage", "increased", "sensitivity", "to", "ionizing", "radiation", "IR", ")", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1739091", "name": "C1739091#ent", "pos": [2, 3]}}
{"token": ["This", "resulted", "in", "the", "activation", "of", "the", "C0026705#ent", "<e1>", ",", "especially", "the", "supplementary", "motor", "area", "C4284041#ent", "<e2>", ")", ",", "which", "released", "the", "starting", "signal", "for", "the", "execution", "of", "the", "motor", "act", "."], "h": {"id": "C0026705", "name": "C0026705#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284041", "name": "C4284041#ent", "pos": [15, 16]}}
{"token": ["With", "its", "efficacy", ",", "safety", ",", "and", "ease", "of", "administration", ",", "C0244656#ent", "<e1>", "is", "a", "valuable", "option", "for", "the", "treatment", "of", "C0038220#ent", "<e2>"], "h": {"id": "C0244656", "name": "C0244656#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [21, 22]}}
{"token": ["Exposure", "of", "AGS", "cells", "to", "C0815040#ent", "<e1>", "pH", "alone", "did", "not", "enhance", "C1705592#ent", "<e2>", "production", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [12, 13]}}
{"token": ["Type", "I", "to", "nail", "disorders", "as", "peculiar", "features", "among", "the", "various", "symptoms", "of", "C0012634#ent", "<e1>", "as", "peri-ungueal", "vascular", "dilatation", ",", "onycholysis", ",", "C0263534#ent", "<e2>", "opaque", "nails", "or", "melanonychia", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0263534", "name": "C0263534#ent", "pos": [22, 23]}}
{"token": ["C1826563#ent", "<e1>", "may", "facilitate", "dephosphorylation", "of", "C2697954#ent", "<e2>", "by", "PP2A", "phosphatase", "while", "cellular", "overexpression", "C1826563#ent", "<e1>", "causes", "a", "reduction", "in", "the", "amyloidogenic", "processing", "APP", ",", "making", "this", "enzyme", "an", "interesting", "target", "for", "pharmaceutical", "intervention"], "h": {"id": "C2697954", "name": "C2697954#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1826563", "name": "C1826563#ent", "pos": [0, 1]}}
{"token": ["All", "these", "actions", "make", "the", "C0074722#ent", "<e1>", "a", "true", "C2936489#ent", "<e2>", "drugs", "."], "h": {"id": "C0074722", "name": "C0074722#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936489", "name": "C2936489#ent", "pos": [9, 10]}}
{"token": ["More", "definitive", "information", "on", "their", "roles", "in", "spermiogenesis", "has", "recently", "been", "obtained", "using", "mice", "with", "null", "mutations", "the", "C0146524#ent", "<e1>", "or", "Tnp2", "genes", "for", "C1336603#ent", "<e2>", "and", "TP2", ",", "respectively", "."], "h": {"id": "C0146524", "name": "C0146524#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1336603", "name": "C1336603#ent", "pos": [24, 25]}}
{"token": ["Idiopathic", "bilateral", "C0006123#ent", "<e1>", "IBRBRAO", ")", "is", "a", "rare", "C1848862#ent", "<e2>", "characterized", "by", "migraine", "headaches", "tinnitus", ",", "vertigo", ",", "hearing", "loss", "and", "recurrent", "branch", "retinal", "artery", "occlusion", "unknown", "etiology", "."], "h": {"id": "C0006123", "name": "C0006123#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [9, 10]}}
{"token": ["The", "lack", "of", "a", "gold", "standard", "the", "diagnosis", "of", "C0022104#ent", "<e1>", ",", "and", "the", "existence", "of", "a", "variety", "of", "C0277524#ent", "<e2>", "similar", "manifestations", "to", "those", "of", "C0022104#ent", "<e1>", "make", "the", "differential", "diagnosis", "difficult", "."], "h": {"id": "C0277524", "name": "C0277524#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [9, 10]}}
{"token": ["Although", "most", "patients", "had", "evidence", "of", "obstructive", "coronary", "disease", "C0027051#ent", "<e1>", "8", "percent", "had", "no", "significant", "C0042373#ent", "<e2>", "acute", "thrombosis", "myocarditis", "or", "valve", "disease", "might", "be", "implicated", "as", "a", "factor", "in", "sudden", "death"], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [16, 17]}}
{"token": ["Antisense", "riboprobes", "for", "C4042618#ent", "<e1>", "mRNA", "were", "used", "to", "map", "the", "C0017337#ent", "<e2>", "in", "mouse", "brain", "by", "in", "situ", "hybridization"], "h": {"id": "C4042618", "name": "C4042618#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["A", "higher", "dosage", "of", "40", "mg/kg", "or", "2", "g", "in", "adults", "given", "tds", "would", "be", "recommended", "for", "C0025289#ent", "<e1>", "based", "on", "the", "penetration", "of", "C0541153#ent", "<e2>", "into", "CSF", "."], "h": {"id": "C0025289", "name": "C0025289#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0541153", "name": "C0541153#ent", "pos": [24, 25]}}
{"token": ["Many", "clinicians", "are", "utilizing", "a", "2-g", "loading", "dose", "C0038745#ent", "<e1>", "in", "the", "treatment", "of", "uncomplicated", "C0042029#ent", "<e2>"], "h": {"id": "C0038745", "name": "C0038745#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [15, 16]}}
{"token": ["The", "patients", "received", "C0038745#ent", "<e1>", "prophylactically", "for", "C0042029#ent", "<e2>", "7", "days", "postoperatively", "."], "h": {"id": "C0038745", "name": "C0038745#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [7, 8]}}
{"token": ["In", "HCA-7", "colon", "cancer", "cells", "DCA", "activated", "Ras", "and", "increased", "C3540509#ent", "<e1>", "and", "Cox-2", "by", "a", "mechanism", "requiring", "the", "C1456378#ent", "<e2>"], "h": {"id": "C3540509", "name": "C3540509#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", ",", "we", "show", "that", "C1332119#ent", "<e1>", "itself", "acts", "as", "a", "substrate", "of", "C1413132#ent", "<e2>", "the", "programmed", "cell", "death"], "h": {"id": "C1332119", "name": "C1332119#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413132", "name": "C1413132#ent", "pos": [15, 16]}}
{"token": ["C0520909#ent", "<e1>", "subsequently", "found", "to", "be", "due", "to", "C0020437#ent", "<e2>", "and", "primary", "hyperparathyroidism"], "h": {"id": "C0520909", "name": "C0520909#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [8, 9]}}
{"token": ["C3890941#ent", "<e1>", "GBS", ")", "is", "an", "C0029877#ent", "<e2>", "may", "implicate", "proinflammatory", "cytokines", "as", "TNF-alpha", "in", "its", "pathogenesis", "."], "h": {"id": "C3890941", "name": "C3890941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [6, 7]}}
{"token": ["C0022020#ent", "<e1>", "failed", "to", "elicit", "an", "IFN-alpha-repressible", "apoptotic", "response", "either", "C2987364#ent", "<e2>", "Daudi", "cells", "or", "IFN-resistant", "sublines", "that", "were", "refractory", "to", "the", "growth-arresting", "effects", "of", "the", "cytokine", "."], "h": {"id": "C0022020", "name": "C0022020#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [10, 11]}}
{"token": ["The", "C0599532#ent", "<e1>", "antioxidant", "N-acetyl", "cysteine", ",", "extracellular", "catalase", "and", "C0669372#ent", "<e2>", "inhibited", "ICAM-1", "and", "IL-8", "increases", "in", "response", "to", "both", "phenazines", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}}
{"token": ["C1571622#ent", "<e1>", "(", "also", "known", "as", "pre-B", "cell", "colony-enhancing", "factor", "PBEF", ")", "is", "a", "C1333196#ent", "<e2>", "that", "is", "highly", "expressed", "in", "visceral", "fat", "whose", "blood", "levels", "with", "obesity", "."], "h": {"id": "C1571622", "name": "C1571622#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [14, 15]}}
{"token": ["We", "report", "a", "60-year-old", "man", "with", "C3890018#ent", "<e1>", "who", "presented", "with", "colicky", "abdominal", "pain", "bloody", "diarrhea", "arthralgia", ",", "and", "C0015230#ent", "<e2>"], "h": {"id": "C3890018", "name": "C3890018#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [19, 20]}}
{"token": ["TRPV1", "was", "activated", "by", "C0026481#ent", "<e1>", "(", "MGs", ")", "having", "C3889128#ent", "<e2>", "and", "C20", "unsaturated", "and", "C8-C12", "saturated", "fatty", "acid", "(", "FA", ")", "."], "h": {"id": "C0026481", "name": "C0026481#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [10, 11]}}
{"token": ["In", "the", "patient", "predisposed", "to", "C0854248#ent", "<e1>", "a", "third-generation", "cephalosporin", "or", "without", "an", "C0002556#ent", "<e2>", "is", "the", "usual", "choice", "."], "h": {"id": "C0854248", "name": "C0854248#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002556", "name": "C0002556#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "further", "report", "that", "stimulation", "with", "GM-CSF", "causes", "phosphorylation", "of", "Syk", "protein", "kinase", "but", "neither", "C1452695#ent", "<e1>", "Cbl", ")", "nor", "C1332672#ent", "<e2>", "in", "CD34(+", ")", "hemopoietic", "progenitors", "be", "blocked", "by", "anti-CD116", "mAb", "."], "h": {"id": "C1452695", "name": "C1452695#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332672", "name": "C1332672#ent", "pos": [21, 22]}}
{"token": ["There", "were", "no", "C0162869#ent", "<e1>", "acute", "biliary", "problems", "needing", "emergency", "operation", "any", "patient", "with", "C0008350#ent", "<e2>", "."], "h": {"id": "C0162869", "name": "C0162869#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008350", "name": "C0008350#ent", "pos": [14, 15]}}
{"token": ["Importantly", ",", "the", "efficacy", "and", "tolerability", "of", "C0073633#ent", "<e1>", "ER", "were", "not", "affected", "by", "old", "age", "co-morbid", "conditions", "C0018801#ent", "<e2>", "diabetes", "mellitus", "."], "h": {"id": "C0073633", "name": "C0073633#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}}
{"token": ["Collagenase", "was", "found", "localized", "in", "frozen", "sections", "canal", "wall", "skin", ",", "middle", "ear", "granulation", "in", "C0155490#ent", "<e1>", "by", "a", "specific", "binding", "of", "the", "C0014442#ent", "<e2>", "with", "an", "antiserum", "produced", "against", "purified", "human", "skin", "collagenase"], "h": {"id": "C0155490", "name": "C0155490#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [23, 24]}}
{"token": ["The", "main", "predisposing", "factors", "the", "development", "of", "candidaemia", "were", ":", "broad", "spectrum", "antibiotics", ",", "central", "venous", "catheters", "C0027947#ent", "<e1>", ",", "cytotoxic", "chemotherapy", "coexisting", "bacterial", "infections", "steroid", "therapy", "relapsing", "or", "untreated", "C0277554#ent", "<e2>", "fluconazole", "prophylaxis"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0277554", "name": "C0277554#ent", "pos": [30, 31]}}
{"token": ["The", "effects", "of", "C0039663#ent", "<e1>", "THC", ")", "and", "C0019873#ent", "<e2>", "EB", ")", "on", "the", "developmental", "life", "cycle", "DNA", "metabolism", "Volvox", "carteri", "been", "investigated", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019873", "name": "C0019873#ent", "pos": [8, 9]}}
{"token": ["Clinical", "trials", "shown", "that", "C0076829#ent", "<e1>", "is", "effective", "as", "adjunctive", "therapy", "treating", "adult", "partial-onset", "epilepsy", "or", "without", "C0234533#ent", "<e2>"], "h": {"id": "C0076829", "name": "C0076829#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0234533", "name": "C0234533#ent", "pos": [17, 18]}}
{"token": ["The", "factors", "responsible", "for", "this", "reactivation", "are", "chronic", "liver", "disease", "other", "coexisting", "infections", ",", "particularly", "C0026946#ent", "<e1>", "pneumocystis", "pneumonia", "nocardia", ",", "and", "C0158945#ent", "<e2>"], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0158945", "name": "C0158945#ent", "pos": [22, 23]}}
{"token": ["Polyethyleneimine", "or", "C0032518#ent", "<e1>", "of", "differing", "molecular", "sizes", "were", "substituted", "with", "either", "C0013618#ent", "<e2>", "or", "DTPA", "and", "then", "with", "succinic", "acid", "groups", "."], "h": {"id": "C0032518", "name": "C0032518#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "high", "VT", "induced", "C0019139#ent", "<e1>", "production", "is", "dependent", "on", "de", "novo", "synthesis", "through", "C0063046#ent", "<e2>", "and", "plays", "a", "role", "in", "the", "inflammatory", "response", "ventilator-induced", "lung", "injury"], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0063046", "name": "C0063046#ent", "pos": [16, 17]}}
{"token": ["We", "hypothesized", "that", "C0019139#ent", "<e1>", "induced", "by", "high", "VT", "was", "dependent", "on", "C0063046#ent", "<e2>", "and", "was", "associated", "with", "ventilator-induced", "lung", "injury"], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0063046", "name": "C0063046#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "large", "doses", "C0025819#ent", "<e1>", "MPSS", ")", "and", "two", "protease", "inhibitors", "C0064858#ent", "<e2>", "and", "bestatin", ",", "on", "experimental", "acute", "spinal", "cord", "injury", "evaluated", "by", "morphometric", "analysis", "degenerating", "axons", "with", "the", "aid", "of", "an", "automated", "image", "analyzer"], "h": {"id": "C0025819", "name": "C0025819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0064858", "name": "C0064858#ent", "pos": [13, 14]}}
{"token": ["Patients", "with", "C2103602#ent", "<e1>", "at", "relatively", "high", "risk", "other", "C0014130#ent", "<e2>", "non-endocrine", "autoimmune", "diseases"], "h": {"id": "C2103602", "name": "C2103602#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [9, 10]}}
{"token": ["Case", "reports", "three", "patients", "with", "C2103602#ent", "<e1>", "with", "other", "associated", "autoimmune", "endocrine", "C0014130#ent", "<e2>", "presented", "."], "h": {"id": "C2103602", "name": "C2103602#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [12, 13]}}
{"token": ["Within", "specimens", ",", "the", "levels", "of", "C3811072#ent", "<e1>", "mRNA", "showed", "a", "high", "degree", "of", "correlation", "with", "both", "C1708268#ent", "<e2>", "and", "HD6", "mRNA", "."], "h": {"id": "C3811072", "name": "C3811072#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1708268", "name": "C1708268#ent", "pos": [17, 18]}}
{"token": ["Recently", "we", "provided", "the", "in-vivo", "data", "on", "C0003286#ent", "<e1>", "efficacy", "of", "C0002502#ent", "<e2>", "(", "an", "NHE", "inhibitor", ")", "in", "different", "animal", "models", "seizure", "and", "epilepsy", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [11, 12]}}
{"token": ["The", "authors", "report", "two", "cases", "of", "C0039483#ent", "<e1>", "one", "case", "of", "C1527406#ent", "<e2>", "treated", "initially", "with", "delta-cortisone", "with", "a", "very", "rapid", "favourable", "result", "."], "h": {"id": "C0039483", "name": "C0039483#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1527406", "name": "C1527406#ent", "pos": [11, 12]}}
{"token": ["Triple", "mutant", "clones", "of", "Rac1", ",", "Rac2", "and", "Mtl", "were", "found", "to", "exhibit", "mild", "PCP", "defects", "which", "were", "enhanced", "by", "reduction", "of", "C1366537#ent", "<e1>", "function", "with", "a", "hypomorphic", "Cdc42", "C0002085#ent", "<e2>", "."], "h": {"id": "C1366537", "name": "C1366537#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [29, 30]}}
{"token": ["A", "clinicopathologic", "study", "multiple", "extramacular", "drusen", "(", "C1413597#ent", "<e1>", ")", "was", "performed", "on", "784", "C0235267#ent", "<e2>", "of", "412", "consecutive", "autopsies", "and", "on", "100", "C0235267#ent", "<e2>", "of", "50", "consecutive", "patients", "with", "C1413597#ent", "<e1>", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413597", "name": "C1413597#ent", "pos": [7, 8]}}
{"token": ["Main", "causes", "of", "C0035078#ent", "<e1>", "were", "glomerulonephritis", "(", "30", "%", ")", ";", "C4049993#ent", "<e2>", "11", "%", "and", "diabetic", "nephropathy", "%", "of", "all", "primary", "renal", "diseases"], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4049993", "name": "C4049993#ent", "pos": [12, 13]}}
{"token": ["Induced", "by", "a", "wide", "range", "of", "pathogenic", "stimuli", ",", "C1710304#ent", "<e1>", "induces", "other", "inflammatory", "mediators", "C1947941#ent", "<e2>", "that", "orchestrate", "inflammatory", "responses"], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [15, 16]}}
{"token": ["Using", "GST", "pull", "down", ",", "co-immunoprecipitation", "assay", "tau-coated", "ELISA", ",", "the", "molecular", "interaction", "tau", "protein", "C1412228#ent", "<e1>", "was", "confirmed", "in", "the", "context", "of", "the", "full-length", "human", "C2697954#ent", "<e2>", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2697954", "name": "C2697954#ent", "pos": [26, 27]}}
{"token": ["Encephalitis", "due", "to", "other", "flaviviruses", "such", "as", "equine", ",", "St.", "Louis", "and", "C1096184#ent", "<e1>", "also", "manifest", "with", "C4023516#ent", "<e2>"], "h": {"id": "C1096184", "name": "C1096184#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4023516", "name": "C4023516#ent", "pos": [17, 18]}}
{"token": ["A", "total", "of", "59", "patients", "(", "118", "eyes", ")", "with", "fundus", "flavimaculatus", "had", "C0332573#ent", "<e1>", "examined", "for", "C0034951#ent", "<e2>"], "h": {"id": "C0332573", "name": "C0332573#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0034951", "name": "C0034951#ent", "pos": [17, 18]}}
{"token": ["Additional", "characteristics", "include", "six", "heptad", "repeats", "hydrophobic", "amino", "acids", ",", "four", "of", "which", "form", "a", "C0079686#ent", "<e1>", "the", "rat", "C1334899#ent", "<e2>"], "h": {"id": "C0079686", "name": "C0079686#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [19, 20]}}
{"token": ["These", "data", "suggest", "that", "C0025376#ent", "<e1>", "or", "a", "non-steroidal", "anti-inflammatory", "agent", "by", "virtue", "of", "their", "C0037766#ent", "<e2>", "a", "superior", "choice", "of", "therapy", "for", "the", "acutely", "obstructed", "ureter"], "h": {"id": "C0025376", "name": "C0025376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037766", "name": "C0037766#ent", "pos": [15, 16]}}
{"token": ["Ten", "patients", "with", "pseudotumor", "cerebri", "associated", "with", "C0035078#ent", "<e1>", "papilledema", "and", "elevated", "intracranial", "pressure", "but", "neurologic", "examinations", "C3813556#ent", "<e2>", "were", "normal", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3813556", "name": "C3813556#ent", "pos": [17, 18]}}
{"token": ["To", "assess", "whether", "r-HuEPO", "(", "recombinant", "human", "erythropoietin", ")", "has", "any", "effect", "on", "C0812443#ent", "<e1>", "in", "patients", "with", "C0022661#ent", "<e2>"], "h": {"id": "C0812443", "name": "C0812443#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [18, 19]}}
{"token": ["A", "12-year-old", "girl", "who", "underwent", "a", "splenectomy", "followed", "by", "heterotopic", "splenic", "autotransplantation", "treatment", "of", "C0020532#ent", "<e1>", "secondary", "to", "C1961835#ent", "<e2>", "the", "age", "of", "3", "years", "presented", "with", "acute", "lower", "abdominal", "pain", "."], "h": {"id": "C0020532", "name": "C0020532#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [18, 19]}}
{"token": ["C3888044#ent", "<e1>", "bound", "strongly", "to", "C3889128#ent", "<e2>", "and", "D5", "and", "only", "weakly", "to", "D2", ",", "D3", "and", "D4", "."], "h": {"id": "C3888044", "name": "C3888044#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [5, 6]}}
{"token": ["In", "mammals", ",", "the", "protein", "incorporates", "additional", "residues", "specified", "by", "an", "alternative", "reading", "frame", "the", "second", "exon", "of", "C0525037#ent", "<e1>", ",", "but", "this", "arrangement", "does", "not", "apply", "to", "the", "C1334043#ent", "<e2>"], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [29, 30]}}
{"token": ["Skin", "tests", "rabbits", "immunized", "with", "C1708620#ent", "<e1>", "mixed", "with", "CFA", "showed", "Arthus", "reactions", "C0265493#ent", "<e2>", ",", "PG", ",", "and", "ribitol", "teichoic", "acid", "delayed", "hypersensitivity", "reactions", "CWs", "and", "PG", "."], "h": {"id": "C1708620", "name": "C1708620#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0265493", "name": "C0265493#ent", "pos": [13, 14]}}
{"token": ["C0268528#ent", "<e1>", "has", "been", "found", "in", "a", "subset", "of", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e2>", ")", "patients", "."], "h": {"id": "C0268528", "name": "C0268528#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [12, 13]}}
{"token": ["The", "lack", "of", "RNA", "dependency", "and", "some", "of", "the", "mutational", "phenotypes", "of", "C3813716#ent", "<e1>", "differentiate", "this", "C0017337#ent", "<e2>", "from", "other", "members", "of", "the", "family", "."], "h": {"id": "C3813716", "name": "C3813716#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["In", "order", "to", "better", "understand", "the", "mechanisms", "leading", "to", "insulin", "resistance", "the", "number", "of", "fat", "tissue", "C1334133#ent", "<e1>", "their", "affinity", "and", "insulin", "receptor", "protein", "rats", "with", "C0142825#ent", "<e2>", "glutamate-induced", "obesity", "were", "studied", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0142825", "name": "C0142825#ent", "pos": [26, 27]}}
{"token": ["In", "this", "study", ",", "analogues", "of", "olomoucine", ",", "a", "previously", "described", "plant", "cytokinin", "analogue", "C0243045#ent", "<e1>", "CDK", ")", "inhibitory", "activity", "were", "investigated", "for", "effect", "on", "C1332721#ent", "<e2>", "and", "CDK2", "and", "for", "effect", "on", "cell", "proliferation"], "h": {"id": "C0243045", "name": "C0243045#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332721", "name": "C1332721#ent", "pos": [25, 26]}}
{"token": ["Calculation", "of", "free-water", "clearance", "in", "the", "diagnosis", "of", "C0004775#ent", "<e1>", "the", "etiology", "and", "characteristics", "of", "the", "C0039082#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [16, 17]}}
{"token": ["The", "altered", "physiology", "of", "C0004775#ent", "<e1>", "reviewed", "and", "the", "pathogenesis", "of", "the", "C0039082#ent", "<e2>", "analyzed", "in", "the", "light", "of", "recent", "literature", "."], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}}
{"token": ["Biochemical", "and", "confocal", "microscopy", "indicate", "that", "C1422148#ent", "<e1>", "retains", "C3889744#ent", "<e2>", "in", "the", "endoplasmic", "reticulum", "ER", ")", "and", "induces", "C3889744#ent", "<e2>", "proteasomeal", "degradation"], "h": {"id": "C1422148", "name": "C1422148#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3889744", "name": "C3889744#ent", "pos": [9, 10]}}
{"token": ["A", "prolonged", "administration", "of", "200", "IU", "C1367551#ent", "<e1>", "inhibits", "parameters", "of", "bone", "resorption", "can", "increase", "lumbar", "spine", "bone", "mineral", "density", "C1414083#ent", "<e2>", ")", "by", "1.7%-3.3", "%", "after", "1", "year", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [20, 21]}}
{"token": ["These", "studies", "suggest", "that", "C0035064#ent", "<e1>", "such", "as", "fatty", "acids", "significantly", "alter", "the", "metabolic", "susceptibility", "C1414382#ent", "<e2>", "in", "vivo", "possibly", "contribute", "to", "the", "degradation", "of", "elastic", "lamellae", "seen", "in", "arteries", "with", "advanced", "atherosclerosis", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [15, 16]}}
{"token": ["Angiotensin-II", "can", "exert", "trophic", "effects", "cardiocytes", "and", "cardiac", "fibroblasts", "and", "chronic", "inhibition", "the", "cardiac", "RAS", "C0003015#ent", "<e1>", "or", "AT", "receptor", "antagonists", "can", "induce", "partial", "regression", "C0020488#ent", "<e2>", "even", "without", "normalizing", "the", "overload", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0020488", "name": "C0020488#ent", "pos": [25, 26]}}
{"token": ["The", "rates", "of", "sulfation", "were", "determined", "from", "the", "initial", "rates", "of", "chiral", "inversion", "the", "alcohol", ",", "knowing", "that", "hydrolysis", "follows", "an", "C3811213#ent", "<e1>", "mechanism", "and", "therefore", "produces", "C0001975#ent", "<e2>"], "h": {"id": "C3811213", "name": "C3811213#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [27, 28]}}
{"token": ["Forty", "tumors", ",", "29", "linked", "to", "BRCA1", "and", "11", "linked", "to", "C0598034#ent", "<e1>", ",", "were", "examined", "for", "mutational", "alterations", "P53", ",", "K-RAS", ",", "C0242957#ent", "<e2>", ",", "C-MYC", ",", "and", "AKT2", "."], "h": {"id": "C0598034", "name": "C0598034#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [23, 24]}}
{"token": ["Xylazine", "reversal", "agent", ",", "C0040373#ent", "<e1>", "(", "2.2", "mg/kg", ")", ",", "was", "given", "to", "C3811169#ent", "<e2>", "1", "to", "hasten", "the", "recovery", ";", "the", "C3811169#ent", "<e2>", "stood", "within", "30", "minutes", "after", "C0040373#ent", "<e1>", "administration", "."], "h": {"id": "C0040373", "name": "C0040373#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3811169", "name": "C3811169#ent", "pos": [14, 15]}}
{"token": ["Fractions", "were", "incubated", "with", "[gamma-32P]ATP", ",", "and", "labelling", "of", "phosphatidylinositol", "4-phosphate", "C0136804#ent", "<e1>", "used", "to", "measure", "phosphatidylinositol", "kinase", "C0207206#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0136804", "name": "C0136804#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0207206", "name": "C0207206#ent", "pos": [18, 19]}}
{"token": ["The", "nucleotide", "sequences", "310", "bp", ")", "of", "the", "groEL", "gene", "which", "encode", "the", "60-kDa", "heat", "shock", "protein", "C3538704#ent", "<e1>", "from", "31", "reference", "strains", "of", "C0024198#ent", "<e2>", "were", "determined", "and", "compared", "."], "h": {"id": "C3538704", "name": "C3538704#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0024198", "name": "C0024198#ent", "pos": [24, 25]}}
{"token": ["We", "also", "labeled", "lightly", "fixed", "rabbit", "retinas", "with", "antisera", "to", "choline", "acetyltransferase", "ChAT", ")", ",", "AMPA", "receptor", "subunits", "GluR1", ",", "GluR2/3", ",", "or", "C1415289#ent", "<e1>", ",", "and", "kainate", "receptor", "subunits", "and", "C1415297#ent", "<e2>", "."], "h": {"id": "C1415289", "name": "C1415289#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1415297", "name": "C1415297#ent", "pos": [31, 32]}}
{"token": ["Restriction", "enzyme", "analysis", "that", "there", "was", "a", "single", "C1709995#ent", "<e1>", "the", "27", "kbp", "of", "C0036117#ent", "<e2>", "genomic", "region", "pSI623", ",", "and", "no", "C1709995#ent", "<e1>", "found", "on", "the", "4.5", "kbp", "of", "genomic", "region", "pSV6235", "."], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1709995", "name": "C1709995#ent", "pos": [8, 9]}}
{"token": ["Protein", "and", "C1412332#ent", "<e1>", "concentrations", "in", "saliva", "of", "individuals", "with", "C0017574#ent", "<e2>", "or", "periodontitis", "were", "significantly", "increased", "compared", "with", "healthy", "subjects"], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017574", "name": "C0017574#ent", "pos": [10, 11]}}
{"token": ["We", "recently", "described", "a", "novel", "murine", "C0387658#ent", "<e1>", ",", "M3/6", ",", "which", "is", "uniquely", "specific", "for", "C1434639#ent", "<e2>", "p38", "kinase"], "h": {"id": "C0387658", "name": "C0387658#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1434639", "name": "C1434639#ent", "pos": [16, 17]}}
{"token": ["During", "immunological", "treatment", "recent", "onset", "diabetes", ",", "serum", "C1705979#ent", "<e1>", "remained", "stable", "and", "was", "not", "modified", "by", "C0010592#ent", "<e2>", "A.", "As", "expected", "C1705979#ent", "<e1>", "became", "undetectable", "during", "treatment", "with", "anti", "IL2R", "MC", "Ab", "."], "h": {"id": "C1705979", "name": "C1705979#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [17, 18]}}
{"token": ["These", "data", "suggest", "that", "muscarine", "reduces", "C1413043#ent", "<e1>", "+", "entry", "in", "C1420276#ent", "<e2>", "DA", "neurons", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [11, 12]}}
{"token": ["Liver", "biopsy", "C0267812#ent", "<e1>", "many", "eosinophils", "in", "the", "portal", "tracts", "giant", "C0669372#ent", "<e2>", "with", "multiple", "nucleoli", "the", "lobule", "."], "h": {"id": "C0267812", "name": "C0267812#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [11, 12]}}
{"token": ["C1419385#ent", "<e1>", "is", "a", "photoreceptive", "protein", "is", "present", "in", "rod", "photoreceptor", "cells", "inducing", "a", "C0120465#ent", "<e2>", "the", "retinal", "G-protein", "transducin", "Gt", ")", "upon", "light", "absorption"], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [14, 15]}}
{"token": ["Having", "a", "tattoo", "has", "been", "associated", "with", "serological", "evidence", "of", "C0019163#ent", "<e1>", "C", "viruses", "as", "well", "as", "human", "C0001175#ent", "<e2>", "syphilis", ";", "all", "of", "these", "are", "known", "to", "be", "transmissible", "by", "blood", "transfusion"], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [18, 19]}}
{"token": ["Many", "dentists", "do", "not", "understand", "that", "C0019163#ent", "<e1>", "a", "greater", "threat", "to", "their", "lives", "and", "health", "than", "C0001175#ent", "<e2>", "AIDS", ")", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "azidothymidine", "(", "AZT", ")", "on", "hepatitis", "B", "virus", "C0019163#ent", "<e1>", ")", "replication", "was", "determined", "in", "three", "patients", "with", "the", "C0001175#ent", "<e2>", "AIDS", ")", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [22, 23]}}
{"token": ["An", "item-specific", "orienting", "C0310298#ent", "<e1>", "leads", "to", "parallel", "serial", "position", "curves", "in", "C1631597#ent", "<e2>", "and", "SPTs", "with", "no", "primacy", "effect", "but", "a", "clear", "recency", "effect"], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1631597", "name": "C1631597#ent", "pos": [12, 13]}}
{"token": ["In", "10", "recipients", "with", "steroid-sensitive", "rejections", "and", "in", "11", "recipients", "with", "C0403397#ent", "<e1>", "rejections", ",", "no", "rejection-associated", "changes", "of", "the", "C1416801#ent", "<e2>", "levels", "could", "be", "shown", "."], "h": {"id": "C0403397", "name": "C0403397#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416801", "name": "C1416801#ent", "pos": [20, 21]}}
{"token": ["Alternatively", ",", "C0036078#ent", "<e1>", "is", "effective", "in", "the", "presence", "of", "C0009373#ent", "<e2>"], "h": {"id": "C0036078", "name": "C0036078#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009373", "name": "C0009373#ent", "pos": [10, 11]}}
{"token": ["To", "enlighten", "the", "role", "of", "protein", "and", "C1705556#ent", "<e1>", "in", "this", "phenomenon", ",", "iron", "transfer", "ferric", "lactate", "C1412332#ent", "<e2>", "and", "adenosine", "polyphosphates", "was", "determined", "by", "electrophoresis", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [17, 18]}}
{"token": ["Control", "experiments", "C1705556#ent", "<e1>", "showed", "that", "little", "radionuclide", "was", "transferred", "from", "TF", "to", "C1412332#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [13, 14]}}
{"token": ["Sequential", "radionuclide", "solid", "egg", "meal", "gastric", "emptying", "studies", "were", "used", "to", "document", "C0152020#ent", "<e1>", ",", "the", "response", "to", "C0025853#ent", "<e2>", "and", "its", "transient", "nature", "."], "h": {"id": "C0152020", "name": "C0152020#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "the", "involvement", "of", "these", "C1332163#ent", "<e1>", "the", "signaling", "pathway", "induced", "by", "C1704691#ent", "<e2>", "or", "interleukin", "(", "IL", ")", "2R", "triggering", "in", "human", "natural", "killer", "NK", ")", "cells", "."], "h": {"id": "C1332163", "name": "C1332163#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704691", "name": "C1704691#ent", "pos": [13, 14]}}
{"token": ["The", "C1333195#ent", "<e1>", "represented", "by", "80", "C1417679#ent", "<e2>", "in", "animal", "genomes", "perhaps", "more", "than", "300", "C1417679#ent", "<e2>", "in", "plant", "genomes", "."], "h": {"id": "C1333195", "name": "C1333195#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}}
{"token": ["We", "have", "explored", "SAR", "around", "the", "C-terminal", "amide", "for", "inhibition", "of", "C1335224#ent", "<e1>", ",", "plasmin", "and", "C0041236#ent", "<e2>", "."], "h": {"id": "C1335224", "name": "C1335224#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [16, 17]}}
{"token": ["Results", "indicate", "that", "C0013384#ent", "<e1>", "and", "stereotypy", "are", "discriminable", "C0026650#ent", "<e2>", "provide", "preliminary", "support", "for", "the", "hypothesis", "that", "they", "may", "be", "related", "by", "common", "mechanisms", "."], "h": {"id": "C0013384", "name": "C0013384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [9, 10]}}
{"token": ["The", "relationship", "between", "C0013384#ent", "<e1>", "and", "related", "C0026650#ent", "<e2>", "examined", "as", "a", "function", "of", "cumulative", "exposure", "to", "antipsychotic", "drugs", "APD", ")", "."], "h": {"id": "C0013384", "name": "C0013384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [7, 8]}}
{"token": ["This", "report", "describes", "the", "case", "of", "a", "child", "with", "relapsed", "acute", "lymphoblastic", "leukemia", "ALL", ")", "who", "developed", "C0004030#ent", "<e1>", "subsequent", "multiorgan", "dissemination", "therapeutic", "induction", "was", "treated", "successfuly", "with", "C0537894#ent", "<e2>"], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [28, 29]}}
{"token": ["However", ",", "recent", "reports", "of", "serious", "infections", "like", "C0041323#ent", "<e1>", ",", "demyelinating", "and", "C0751870#ent", "<e2>", "pancytopenia", ",", "cardiovascular", "diseases", "etc", "."], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [13, 14]}}
{"token": ["Using", "an", "antibody", "made", "against", "a", "C0030956#ent", "<e1>", "duplicating", "the", "aminoterminal", "30", "amino", "acid", "sequence", "C1515406#ent", "<e2>", "we", "stained", "sections", "of", "stage", "11", "18", ",", "23", ",", "26", ",", "and", "36", "chick", "hearts", "by", "an", "in", "situ", "immunofluorescence", "technique"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1515406", "name": "C1515406#ent", "pos": [15, 16]}}
{"token": ["Sodium", "dodecyl", "sulphate", "C0007907#ent", "<e1>", "sodium", "deoxycholate", "octyl", "beta-D-glucoside", "digitonin", "and", "C0001975#ent", "<e2>", "less", "effective", "in", "enhancing", "enzyme", "activity", "and", "dimethyl", "sulphoxide", "ineffective", "."], "h": {"id": "C0007907", "name": "C0007907#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "show", "that", "the", "genes", "for", "C1721673#ent", "<e1>", "RALDH2", ")", "and", "a", "C4284143#ent", "<e2>", "CYP26A1", ")", "are", "expressed", "in", "complementary", "patterns", "in", "the", "Xenopus", "gut", "looping", "."], "h": {"id": "C1721673", "name": "C1721673#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4284143", "name": "C4284143#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "bleeding", "duodenal", "gastric", "ulcers", "H.", "pylori", "infection", "randomized", "to", "receive", "either", "a", "one-week", "course", "of", "triple", "therapy", "bismuth", "subcitrate", "C0025872#ent", "<e1>", ",", "and", "tetracycline", "plus", "C0034665#ent", "<e2>", "or", "a", "six-week", "course", "of", "C0034665#ent", "<e2>", "300", "mg/day", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [27, 28]}}
{"token": ["The", "ung", "mutant", "cells", "repaired", "C1420423#ent", "<e1>", "almost", "completely", ",", "whereas", "the", "wild-type", "cells", "with", "C0077845#ent", "<e2>", "produced", "more", "adverse", "C1420423#ent", "<e1>", "by", "90", "min", "after", "UV", "."], "h": {"id": "C0077845", "name": "C0077845#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [5, 6]}}
{"token": ["Lambs", "inoculated", "with", "OAV-6", "or", "C0002878#ent", "<e1>", "mild", "and", "moderate", "C0035242#ent", "<e2>", "6", "and", "3", "days", "'", "duration", ",", "respectively", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [10, 11]}}
{"token": ["The", "classification", "of", "C0263661#ent", "<e1>", "respect", "to", "C1414672#ent", "<e2>", "is", "crucial", "for", "the", "determination", "of", "adequate", "treatment", "."], "h": {"id": "C0263661", "name": "C0263661#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [7, 8]}}
{"token": ["Common", "dietary", "problems", "include", "C0268487#ent", "<e1>", "of", "energy", ",", "calcium", ",", "C3265062#ent", "<e2>", "vitamin", "A", "and", "fiber", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3265062", "name": "C3265062#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "we", "have", "identified", "a", "short", "sequence", "motif", "(", "YV/IN", ")", "present", "in", "C1704984#ent", "<e1>", ",", "EGFR", "and", "C1705297#ent", "<e2>", ",", "which", "specifically", "binds", "the", "SH2", "domain", "GRB2", "with", "high", "affinity", "."], "h": {"id": "C1704984", "name": "C1704984#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [19, 20]}}
{"token": ["To", "investigate", "this", "further", ",", "we", "examined", "the", "occupation", "patterns", "key", "elements", "of", "the", "C1706331#ent", "<e1>", "promoter", "such", "as", "the", "-170", "C1511573#ent", "<e2>", "and", "-150", "CCAAT", "sites", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [21, 22]}}
{"token": ["Inhibition", "of", "extracellular", "signal-regulated", "kinase", "ERK", ")", "or", "Src", "tyrosine", "kinase", "blocked", "aromatase", "gene", "transactivation", "C1413702#ent", "<e1>", "activation", "in", "the", "p53(Delta)(5,6", ")", "C3274839#ent", "<e2>", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3274839", "name": "C3274839#ent", "pos": [22, 23]}}
{"token": ["These", "samples", "were", "obtained", "by", "modification", "of", "a", "commercial", "activated", "carbon", "by", "means", "of", "chemical", "treatment", "C1705347#ent", "<e1>", "(", "acid", "sample", "and", "thermal", "treatment", "a", "flow", "of", "C0919509#ent", "<e2>", "(", "basic", "sample", ")", "."], "h": {"id": "C1705347", "name": "C1705347#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [27, 28]}}
{"token": ["Two", "antifibrinolytic", "drugs", "C0040613#ent", "<e1>", "TXA", ")", "and", "aprotinin", "(", "C1705517#ent", "<e2>", ")", ",", "are", "used", "to", "improve", "the", "recovery", "of", "patients", "following", "cardiac", "surgery", "reducing", "blood", "loss"], "h": {"id": "C0040613", "name": "C0040613#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705517", "name": "C1705517#ent", "pos": [10, 11]}}
{"token": ["CI", "occurs", "in", "dystrophinopathies", ",", "Emery-Dreifuss", "muscular", "dystrophy", "facioscapulohumeral", "muscular", "dystrophy", "C0686353#ent", "<e1>", "laminopathies", ",", "congenital", "muscular", "dystrophies", "myotonic", "dystrophies", "congenital", "myopathies", "metabolic", "myopathies", "desminopathies", ",", "myofibrillar", "myopathy", "C0574083#ent", "<e2>", "McLeod", "syndrome", "Senger's", "syndrome", "and", "Bethlem", "myopathy"], "h": {"id": "C0686353", "name": "C0686353#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0574083", "name": "C0574083#ent", "pos": [28, 29]}}
{"token": ["Concomitantly", ",", "as", "investigated", "by", "RT-PCR", "analysis", "the", "transcriptional", "activity", "c-fos", "and", "c-jun", "was", "stimulated", ",", "without", "C2712370#ent", "<e1>", "mRNA", "expression", "of", "the", "myelin-specific", "genes", "MBP", ",", "C1416969#ent", "<e2>", ",", "and", "PLP", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1416969", "name": "C1416969#ent", "pos": [27, 28]}}
{"token": ["On", "the", "other", "hand", ",", "the", "C0085387#ent", "<e1>", "indomethacin", "(", "0.4", "nmol/l", ")", ",", "significantly", "potentiated", "the", "C0237795#ent", "<e2>", "response", "of", "5-HT", "in", "normal", "but", "not", "in", "diabetic", "pulmonary", "arterial", "rings", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [17, 18]}}
{"token": ["We", "investigated", "immunohistochemically", "the", "localization", "of", "C0812309#ent", "<e1>", ",", "an", "endogenous", "substrate", "protein", "an", "C1567710#ent", "<e2>", "chicken", "liver"], "h": {"id": "C0812309", "name": "C0812309#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1567710", "name": "C1567710#ent", "pos": [14, 15]}}
{"token": ["Endogenous", "infections", "such", "as", "C0006849#ent", "<e1>", "can", "be", "minimized", "by", "C0016277#ent", "<e2>", "prophylaxis", ",", "although", "oral", "or", "intravenous", "amphotericin", "or", "itraconazole", ",", "are", "suitable", "for", "certain", "patients", "."], "h": {"id": "C0006849", "name": "C0006849#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [10, 11]}}
{"token": ["The", "His(H)-Arg(R", ")", "polymorphism", "at", "C2917660#ent", "<e1>", "of", "the", "C1414553#ent", "<e2>", "alters", "binding", "affinity", "for", "human", "IgG2", "and", "influences", "infection", "with", "encapsulated", "organisms", "children", "without", "sickle", "cell", "disease"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414553", "name": "C1414553#ent", "pos": [9, 10]}}
{"token": ["We", "report", "a", "patient", "who", "presented", "with", "acute", "renal", "failure", "later", "experienced", "C0085642#ent", "<e1>", "peripheral", "gangrene", "the", "diagnosis", "of", "C0268164#ent", "<e2>", "established", "."], "h": {"id": "C0085642", "name": "C0085642#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0268164", "name": "C0268164#ent", "pos": [19, 20]}}
{"token": ["In", "a", "majority", "of", "cases", ",", "the", "predominant", "motor", "abnormality", "spasticity", ";", "other", "forms", "of", "C0007789#ent", "<e1>", "dyskinetic", "(", "dystonia", "or", "choreo-athetosis", ")", "and", "C0394005#ent", "<e2>"], "h": {"id": "C0007789", "name": "C0007789#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0394005", "name": "C0394005#ent", "pos": [24, 25]}}
{"token": ["The", "distribution", "of", "C0144300#ent", "<e1>", "(", "tosufloxacin", "tosilate", ")", "in", "C0036091#ent", "<e2>", "rats", "was", "investigated", "with", "frozen-microautoradiography", "."], "h": {"id": "C0144300", "name": "C0144300#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [10, 11]}}
{"token": ["However", ",", "co-transfection", "of", "PalFs", "with", "BPV-4", "DNA", ",", "C0034678#ent", "<e1>", ",", "and", "both", "mutant", "p53", "cDNA", "and", "16E6", "C0013570#ent", "<e2>", "resulted", "in", "cells", "which", "were", "fully", "transformed", "to", "tumorigenicity", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [19, 20]}}
{"token": ["In", "recent", "years", ",", "there", "is", "a", "growing", "interest", "in", "C0031428#ent", "<e1>", "their", "presumed", "role", "in", "the", "prevention", "of", "various", "C1285162#ent", "<e2>", "such", "as", "cancer", "and", "cardiovascular", "diseases"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [20, 21]}}
{"token": ["Thyroid", "scintigraphy", "an", "additional", "method", "for", "determining", "the", "relative", "severity", "of", "C0040128#ent", "<e1>", "is", "less", "affected", "by", "the", "presence", "of", "concurrent", "C0015190#ent", "<e2>", "laboratory", "evaluations"], "h": {"id": "C0040128", "name": "C0040128#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0015190", "name": "C0015190#ent", "pos": [21, 22]}}
{"token": ["This", "patient", "was", "diagnosed", "as", "having", "C0031069#ent", "<e1>", "based", "on", "periodic", "fever", "C0003862#ent", "<e2>", "typical", "of", "this", "disease", "and", "heterozygous", "mutations", "the", "MEFV", "gene"], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [12, 13]}}
{"token": ["In", "this", "article", ",", "the", "spectrum", "of", "C0035204#ent", "<e1>", "by", "systemic", "lupus", "erythematosus", "rheumatoid", "arthritis", "scleroderma", ",", "polymyositis/dermatomyositis", ",", "mixed", "connective", "tissue", "disease", "ankylosing", "spondylitis", "C0032453#ent", "<e2>", "and", "Sj\u00f6gren's", "syndrome", "reviewed", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032453", "name": "C0032453#ent", "pos": [25, 26]}}
{"token": ["The", "coexpression", "studies", "showed", "that", "furin", ",", "PACE4A-II", "and", "C1438155#ent", "<e1>", "were", "all", "able", "to", "convert", "proalbumin", "to", "C1412332#ent", "<e2>", "correctly", "."], "h": {"id": "C1438155", "name": "C1438155#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "the", "intracellular", "localization", "of", "the", "multifunctional", "nonstructural", "protein", "2", "C1705392#ent", "<e1>", ")", "in", "mammalian", "cells", "infected", "with", "Venezuelan", "equine", "encephalitis", "virus", "C0014078#ent", "<e2>", ")", ",", "an", "important", ",", "naturally", "emerging", "zoonotic", "alphavirus", "."], "h": {"id": "C1705392", "name": "C1705392#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014078", "name": "C0014078#ent", "pos": [23, 24]}}
{"token": ["Similarly", ",", "C0077539#ent", "<e1>", ",", "cetyl", "alcohol", "and", "the", "surfactant", "decreased", "hydroxylated", "products", "of", "C0036077#ent", "<e2>", "in", "the", "same", "system", "."], "h": {"id": "C0077539", "name": "C0077539#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [14, 15]}}
{"token": ["Recent", "studies", "with", "varying", "blood-flow", "conditions", "and", "animal", "models", "thrombosis", "have", "provided", "deeper", "insight", "into", "the", "role", "of", "C0169101#ent", "<e1>", "thrombus", "formation", "the", "dependence", "of", "these", "C0031727#ent", "<e2>", "on", "shear", "conditions"], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [18, 19]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [26, 27]}}
{"token": ["Second", "generation", "C0014544#ent", "<e1>", "lamotrigine", "(", "LTG", ")", "and", "C0068897#ent", "<e2>", "(", "TGB", ")", "were", "primarily", "licensed", "for", "adjunctive", "treatment", "simple", "and", "complex", "partial", "seizures", "with/without", "secondary", "generalisation", "similarly", "effective", "drugs", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0068897", "name": "C0068897#ent", "pos": [9, 10]}}
{"token": ["5:2707", "-", "2718", ",", "1991", ")", "consists", "of", "the", "C0017362#ent", "<e1>", "an", "operator-promoter", "region", "followed", "by", "C1428918#ent", "<e2>", "and", "merA", "structural", "genes", "differs", "from", "other", "known", "gram-negative", "mer", "operons"], "h": {"id": "C0017362", "name": "C0017362#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1428918", "name": "C1428918#ent", "pos": [16, 17]}}
{"token": ["The", "frequency", "of", "HLA-antigens", "DR3", "DR4", ",", "DR3/DR4", ",", "B8", ",", "and", "C1417636#ent", "<e1>", "were", "increased", "and", "those", "of", "C1334468#ent", "<e2>", "and", "B7", "decreased", "in", "the", "diabetic", "patients", "."], "h": {"id": "C1417636", "name": "C1417636#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334468", "name": "C1334468#ent", "pos": [19, 20]}}
{"token": ["It", "is", "demonstrated", "that", "C1423607#ent", "<e1>", "causes", "a", "drastic", "inhibition", "of", "this", "C0027203#ent", "<e2>", "indicating", "a", "similar", "sensitivity", "of", "PKC", "to", "C1423607#ent", "<e1>", "in", "intact", "cells", "compared", "to", "cell-free", "extracts"], "h": {"id": "C1423607", "name": "C1423607#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["Both", "proteins", "associate", "with", "the", "cytoskeleton", "upon", "Ca(2+)", "depletion", ",", "although", "only", "C1421419#ent", "<e1>", "seems", "to", "be", "sensitive", "to", "C1822695#ent", "<e2>", "."], "h": {"id": "C1421419", "name": "C1421419#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1822695", "name": "C1822695#ent", "pos": [19, 20]}}
{"token": ["A", "young", "immunocompetent", "patient", "was", "admitted", "for", "a", "febrile", "illness", "with", "malaise", ",", "C0003862#ent", "<e1>", ",", "painful", "leg", "swelling", ",", "and", "C0031069#ent", "<e2>", "."], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [21, 22]}}
{"token": ["The", "c-Jun", "and", "c-Fos", "binding", "sites", "were", "localized", "to", "the", "C-terminal", "subregion", "SRC-1", "(", "C3539946#ent", "<e1>", "-", "1441", ")", "that", "encompasses", "the", "previously", "described", "C0062773#ent", "<e2>", "receptor-binding", "domains", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [24, 25]}}
{"token": ["The", "cause", "of", "C0018801#ent", "<e1>", "be", "defined", "by", "C0020437#ent", "<e2>", ",", "metabolic", "acidosis", "hemoconcentration", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [8, 9]}}
{"token": ["C0066579#ent", "<e1>", "also", "had", "a", "cumulative", "inhibitory", "effect", "brain", "neuropathy", "target", "C1257646#ent", "<e2>", "."], "h": {"id": "C0066579", "name": "C0066579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1257646", "name": "C1257646#ent", "pos": [11, 12]}}
{"token": ["PD", "145065", ",", "but", "not", "BQ-123", ",", "also", "completely", "blocked", "the", "C0237795#ent", "<e1>", "effects", "of", "C0245495#ent", "<e2>"], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0245495", "name": "C0245495#ent", "pos": [15, 16]}}
{"token": ["It", "also", "inhibited", "the", "depressor", "and", "C0237795#ent", "<e1>", "effect", "of", "ET-1", "and", "C0245495#ent", "<e2>"], "h": {"id": "C0237795", "name": "C0237795#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0245495", "name": "C0245495#ent", "pos": [12, 13]}}
{"token": ["The", "resolution", "of", "infections", "with", "the", "C0162572#ent", "<e1>", "parasite", "Leishmania", "major", "mice", "requires", "a", "C3540579#ent", "<e2>", "response", "that", "is", "closely", "associated", "with", "expression", "of", "IL-12", ",", "IFN-gamma", ",", "and", "inducible", "NO", "synthase"], "h": {"id": "C0162572", "name": "C0162572#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [14, 15]}}
{"token": ["EGF", "stimulation", "is", "mediated", "by", "increased", "synthesis", "of", "c-fos", "and", "C0162508#ent", "<e1>", ",", "resulting", "in", "AP-1", "binding", "to", "the", "proximal", "C0020514#ent", "<e2>", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [20, 21]}}
{"token": ["We", "show", "the", "existence", "of", "an", "activating", "protein-1", "C0162508#ent", "<e1>", ")", "response", "element", "at", "positions", "-61", "to", "-54", "of", "the", "proximal", "promoter", ",", "conferring", "C0162508#ent", "<e1>", "stimulation", "to", "the", "C0020514#ent", "<e1>", "promoter", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [29, 30]}}
{"token": ["The", "enzymes", "that", "were", "studied", "from", "sequential", "incubations", "carried", "out", "in", "parallel", ",", "were", "C1825841#ent", "<e1>", "EC", "6.2.1.3", ")", "and", "acyl-CoA", ":", "C0024353#ent", "<e2>", "EC", "2.3.1.23", ")", "(", "ACLAT", ")", "."], "h": {"id": "C1825841", "name": "C1825841#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024353", "name": "C0024353#ent", "pos": [22, 23]}}
{"token": ["IL-1", "also", "activated", "C1416920#ent", "<e1>", "in", "the", "cells", ",", "but", "with", "slower", "kinetics", "than", "C0525678#ent", "<e2>", "."], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [14, 15]}}
{"token": ["NNK", "and", "NNAL", "are", "bioactivated", "to", "C0812382#ent", "<e1>", "intermediates", "via", "hydroxylation", "of", "the", "C0524928#ent", "<e2>", "atoms", "adjacent", "to", "the", "nitroso", "moiety", "(", "i.e.", ",", "alpha-hydroxylation", ")", "by", "cytochrome", "p450s", "p450s", ")", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [13, 14]}}
{"token": ["Increasing", "concentrations", "of", "C0006945#ent", "<e1>", "can", "not", "reverse", "the", "inhibitory", "effect", "of", "the", "C0013227#ent", "<e2>", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [13, 14]}}
{"token": ["Image", "analysis", "performed", "off-line", "at", "30", "Hz", "to", "determine", "refractive", "changes", "and", "ciliary", "body", "lens", "edge", "movements", "during", "EW", "stimulated", "accommodation", "and", "after", "C0006945#ent", "<e1>", "iontophoresis", "to", "determine", "C0013227#ent", "<e2>", "induced", "accommodative", "movements"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [28, 29]}}
{"token": ["To", "assess", "its", "usefulness", "in", "the", "outpatient", "diabetic", "nephropathy", ",", "24", "patients", "with", "C0011854#ent", "<e1>", "56", "iothalamate", "clearances", "during", "water", "diuresis", "56", "simultaneous", "C0043501#ent", "<e2>", "GFR", "estimations", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0043501", "name": "C0043501#ent", "pos": [23, 24]}}
{"token": ["This", "study", "examined", "C0919445#ent", "<e1>", "expression", "in", "human", "ovarian", "cancer", "and", "explored", "the", "association", "between", "C0919445#ent", "<e1>", "and", "prognosis", "in", "patients", "with", "advanced", "stage", "disease", "treated", "with", "cisplatin", ",", "C0079083#ent", "<e1>", "and/or", "paclitaxel", "."], "h": {"id": "C0919445", "name": "C0919445#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [29, 30]}}
{"token": ["The", "effects", "of", "cyclosporine", "(", "C0010592#ent", "<e1>", ")", ",", "sirolimus", "(", "RAPA", ")", ",", "and/or", "C0280509#ent", "<e2>", "(", "BQR", ")", "were", "examined", "in", "a", "vascularized", "heterotopic", "heart", "transplant", "model", "in", "mice", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0280509", "name": "C0280509#ent", "pos": [15, 16]}}
{"token": ["p21", "suppressed", "the", "activity", "of", "E2F-responsive", "promoters", "(", "dihydrofolate", "reductase", "C1418727#ent", "<e1>", ")", ",", "but", "E2F-unresponsive", "promoters", "(", "C1706383#ent", "<e2>", "and", "simian", "virus", "early", ")", "were", "unaffected", "."], "h": {"id": "C1418727", "name": "C1418727#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [18, 19]}}
{"token": ["Total", "or", "partial", "lack", "of", "C1412279#ent", "<e1>", "GDE", "or", "C1412279#ent", "<e1>", ",", "amylo-1,6-glucosidase", ",", "4-alpha-glucanotransferase", ")", "is", "responsible", "for", "Glycogen", "Storage", "Disease", "type", "III", "GSDIII", ")", ",", "a", "rare", "autosomal", "recessive", "disorder", "glycogen", "metabolism"], "h": {"id": "C1412279", "name": "C1412279#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412279", "name": "C1412279#ent", "pos": [5, 6]}}
{"token": ["Our", "experiments", "verified", "that", "RJH", "has", "an", "antioxidative", "effect", "against", "photohemolysis", "and", "supports", "our", "hypothesis", "that", "RJH", "may", "have", "potential", "as", "a", "C0033613#ent", "<e1>", "oxidative", "stress", "associated", "with", "diseases", "such", "as", "C0162565#ent", "<e2>", "."], "h": {"id": "C0033613", "name": "C0033613#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0162565", "name": "C0162565#ent", "pos": [31, 32]}}
{"token": ["The", "recombinant", "HDAg", "polypeptide", "shown", "to", "be", "a", "C1421986#ent", "<e1>", "specificity", "for", "both", "genomic", "and", "C1414313#ent", "<e2>", "hepatitis", "delta", "virus", "RNA"], "h": {"id": "C1421986", "name": "C1421986#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [15, 16]}}
{"token": ["The", "C3853563#ent", "<e1>", "the", "related", "genes", "A-raf", "and", "B-raf", "encode", "C0072402#ent", "<e2>", "to", "be", "involved", "in", "regulating", "gene", "expression", "acting", "as", "part", "of", "second-messenger", "signaling", "pathways", "the", "cell", "."], "h": {"id": "C3853563", "name": "C3853563#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [10, 11]}}
{"token": ["The", "highest", "mutagenic", "activity", "observed", "with", "the", "pyrolysate", "from", "C0031957#ent", "<e1>", ",", "followed", "by", "those", "from", "piperidine", ",", "spermidine", ",", "C0137098#ent", "<e2>", "and", "triethylamine", "."], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0137098", "name": "C0137098#ent", "pos": [20, 21]}}
{"token": ["Consequently", ",", "we", "tested", "additional", "kinases", "and", "found", "that", "C0134982#ent", "<e1>", ",", "but", "not", "C1528376#ent", "<e2>", "or", "Jak2", ",", "is", "a", "potent", "kinase", "of", "Tarp", "in", "vitro"], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1528376", "name": "C1528376#ent", "pos": [14, 15]}}
{"token": ["The", "distribution", "of", "C0003776#ent", "<e1>", "with", "that", "of", "the", "mRNA", ",", "whereas", "C0006961#ent", "<e2>", "present", "in", "all", "enterocytes", "of", "the", "crypts", "and", "villi", "."], "h": {"id": "C0003776", "name": "C0003776#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006961", "name": "C0006961#ent", "pos": [12, 13]}}
{"token": ["The", "basal", "kinase", "of", "protein", "kinase-A", "PKA", ")", ",", "C0248868#ent", "<e1>", "GSK-3", "were", "stimulated", "more", "than", "two-fold", "by", "C0022245#ent", "<e2>", ",", "bradykinin", "and", "wortmannin", ",", "respectively", "."], "h": {"id": "C0248868", "name": "C0248868#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [18, 19]}}
{"token": ["These", "include", "deficiencies", "in", "catalase", ",", "galactokinase", ",", "UDPGlu-4-epimerase", ",", "NADPH", "diaphorase", "C0031653#ent", "<e1>", ",", "acetylcholinesterase", ",", "glutathione", "reductase", "glutathione", "peroxidase", "and", "C0001497#ent", "<e2>"], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001497", "name": "C0001497#ent", "pos": [22, 23]}}
{"token": ["We", "now", "show", "that", "in", "erythroid", "cells", "Lmo2", "forms", "a", "novel", "DNA-binding", "complex", "with", "GATA-1", ",", "TAL1", "and", "C1336596#ent", "<e1>", ",", "and", "the", "recently", "identified", "C1424659#ent", "<e2>", "."], "h": {"id": "C1336596", "name": "C1336596#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1424659", "name": "C1424659#ent", "pos": [25, 26]}}
{"token": ["The", "mechanism", "whereby", "AII", "conserves", "Na", "chronically", "is", "through", "increased", "C0025965#ent", "<e1>", ",", "since", "steady-state", "C0025965#ent", "<e1>", "was", "increased", "by", "AII", "and", "decreased", "by", "C0733566#ent", "<e1>"], "h": {"id": "C0025965", "name": "C0025965#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0733566", "name": "C0733566#ent", "pos": [24, 25]}}
{"token": ["Optimal", "clinical", "application", "C0014025#ent", "<e1>", "in", "the", "treatment", "of", "hypertension", "and", "C0018802#ent", "<e2>", "require", "increased", "awareness", "of", "this", "incessant", "cough", "which", "requires", "discontinuation", "of", "the", "therapy", "in", "about", "10", "%", "of", "patients", "."], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}}
{"token": ["25.1", ",", "a", "novel", "C1423524#ent", "<e1>", "mac25/insulin-like", "growth", "factor-binding", "protein-related", "protein", "1", "mac25/IGFBP-rP1", ")", ",", "induced", "NE-like", "differentiation", "when", "collectively", "C3889446#ent", "<e2>", "in", "M12", "prostate", "cancer", "cells", "."], "h": {"id": "C1423524", "name": "C1423524#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [20, 21]}}
{"token": ["The", "question", "remains", "whether", "C0011847#ent", "<e1>", "increases", "the", "risk", "of", "Alzheimer's", "disease", "C0342245#ent", "<e2>", "whether", "C0011847#ent", "<e1>", "influences", "directly", "the", "development", "of", "Alzheimer", "neuropathology", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0342245", "name": "C0342245#ent", "pos": [12, 13]}}
{"token": ["Tick", "paralysis", "a", "rare", "disease", "characterized", "by", "acute", ",", "ascending", ",", "C0085620#ent", "<e1>", "is", "often", "confused", "with", "other", "acute", "neurologic", "disorders", "C0029896#ent", "<e2>", "(", "e.g.", ",", "Guillain-Barr\u00e9", "syndrome", "botulism", ")", "."], "h": {"id": "C0085620", "name": "C0085620#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [21, 22]}}
{"token": ["C0050423#ent", "<e1>", "are", "obtained", "in", "MeCN", "and", "C3540034#ent", "<e2>", "in", "alcohols", "(", "MeOH", ",", "iso-PrOH", ",", "tert-BuOH", ",", "CF3CH2OH", ")", "."], "h": {"id": "C0050423", "name": "C0050423#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540034", "name": "C3540034#ent", "pos": [7, 8]}}
{"token": ["We", "quantified", "circulating", "ghrelin", "concentrations", "under", "C1321567#ent", "<e1>", "conditions", "combined", "with", "infusion", "of", "gastric", "inhibitory", "polypeptide", "C1422563#ent", "<e2>", ")", "and", "arginine", "."], "h": {"id": "C1321567", "name": "C1321567#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422563", "name": "C1422563#ent", "pos": [16, 17]}}
{"token": ["Following", "combination", "of", "lidocaine", "and", "a", "IC", "agent", "7", "with", "encainide", "and", "5", "with", "flecainide", ")", ",", "two", "had", "no", "C0042514#ent", "<e1>", "VT", ")", "and", "one", "had", "C0750197#ent", "<e2>", "NSVT", ")", "."], "h": {"id": "C0042514", "name": "C0042514#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0750197", "name": "C0750197#ent", "pos": [27, 28]}}
{"token": ["In", "addition", ",", "quercetin", "enhanced", "expression", "of", "tumor", "suppressor", "genes", "including", "Pten", ",", "C1705526#ent", "<e1>", ",", "and", "Msh2", ",", "and", "of", "cell", "cycle", "inhibitors", "including", "C1879506#ent", "<e2>", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1879506", "name": "C1879506#ent", "pos": [25, 26]}}
{"token": ["Here", ",", "we", "report", "a", "new", "strategy", "for", "C0019163#ent", "<e1>", "DNA", "vaccine", "using", "a", "partial", "C3889457#ent", "<e2>", "sequence", "."], "h": {"id": "C0019163", "name": "C0019163#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3889457", "name": "C3889457#ent", "pos": [15, 16]}}
{"token": ["Topical", "application", "of", "5-aminolaevulinic", "acid", "ALA", ")", "to", "C0009663#ent", "<e1>", "to", "accumulation", "of", "protoporphyrin", "IX", "C1121290#ent", "<e2>", ")", ";", "therefore", "ALA-induced", "photodynamic", "therapy", "ALA-PDT", ")", "appears", "to", "be", "a", "potential", "treatment", "."], "h": {"id": "C0009663", "name": "C0009663#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1121290", "name": "C1121290#ent", "pos": [15, 16]}}
{"token": ["We", "have", "further", "studied", "their", "expression", "in", "the", "mouse", "and", "human", "developing", "C0054757#ent", "<e1>", ",", "focusing", "particularly", "on", "C1414228#ent", "<e2>", "."], "h": {"id": "C0054757", "name": "C0054757#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414228", "name": "C1414228#ent", "pos": [18, 19]}}
{"token": ["This", "study", "demonstrated", "a", "number", "of", "nuclear", "53BP1", "foci", "in", "human", "skin", "tumorigenesis", "suggesting", "a", "C0907533#ent", "<e1>", "activation", "of", "C1333206#ent", "<e2>", "in", "skin", "cancer", "cells"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333206", "name": "C1333206#ent", "pos": [19, 20]}}
{"token": ["The", "predominant", "eosinophilic", "infiltration", "of", "the", "mucosal", "layer", "the", "upper", "gastrointestinal", "tract", "in", "severe", "protein-losing", "enteropathy", "C1306759#ent", "<e1>", "one", "patient", "and", "a", "malabsorption", "syndrome", "to", "saccharose", "and", "C0016952#ent", "<e2>", "another", "patient", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [27, 28]}}
{"token": ["The", "combination", "of", "NH", "activation", "and", "renal", "failure", "C1313497#ent", "<e1>", "is", "a", "vasomotor", "nephropathy", "as", "the", "C0795936#ent", "<e2>", "CRS", ")", "and", "portends", "a", "poor", "prognosis"], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0795936", "name": "C0795936#ent", "pos": [16, 17]}}
{"token": ["Histological", "analysis", "the", "C3889703#ent", "<e1>", "expression", "pattern", "revealed", "beta-galactosidase", "activity", "in", "the", "thick", "C0030196#ent", "<e2>", "of", "Henle's", "loop"], "h": {"id": "C3889703", "name": "C3889703#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [13, 14]}}
{"token": ["C0041228#ent", "<e1>", "the", "Trypanosoma", "brucei", "group", "are", "C0991617#ent", "<e2>", "of", "disease", "in", "man", "and", "animals", "."], "h": {"id": "C0041228", "name": "C0041228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [7, 8]}}
{"token": ["Among", "C0206171#ent", "<e1>", ",", "sporadic", "cases", "acute", "and", "chronic", "non-A", ",", "C0019196#ent", "<e2>", "however", ",", "only", "5.7", "%", "and", "15.4", "%", "were", "shown", "to", "possess", "the", "antibody", ",", "respectively", "."], "h": {"id": "C0206171", "name": "C0206171#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019196", "name": "C0019196#ent", "pos": [11, 12]}}
{"token": ["Physical", "examination", "generalized", "seizure", "C0151315#ent", "<e1>", "hyperreflexia", "and", "C0085620#ent", "<e2>", "her", "all", "extremities", ",", "and", "pathological", "reflexes"], "h": {"id": "C0151315", "name": "C0151315#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085620", "name": "C0085620#ent", "pos": [8, 9]}}
{"token": ["Its", "pathologic", "features", "same", "as", "those", "of", "C0035222#ent", "<e1>", ",", "but", "it", "is", "not", "differentiate", "AIP", "from", "C0206061#ent", "<e2>", "the", "basis", "of", "etiology", "."], "h": {"id": "C0035222", "name": "C0035222#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "report", "one", "case", "of", "C0002726#ent", "<e1>", "associated", "with", "muscular", "pseudohypertrophy", "a", "46-year-old", "woman", ",", "who", "developed", "C0427055#ent", "<e2>", ",", "macroglossia", "and", "muscle", "hypertrophy", "associated", "with", "primary", "systemic", "amyloidosis"], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [18, 19]}}
{"token": ["In", "rats", "with", "an", "acute", "pancreatic", "fistula", "5-TG", "and", "C0011501#ent", "<e1>", "induced", "a", "dose-related", "increase", "in", "outputs", "of", "C3714642#ent", "<e2>", "(", "reflecting", "the", "volume", ")", ",", "bicarbonate", "and", "total", "protein", "the", "pancreatic", "juice"], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3714642", "name": "C3714642#ent", "pos": [18, 19]}}
{"token": ["Maturation", "of", "Xenopus", "laevis", "oocytes", "induced", "by", "an", "oncogenic", "human", "C0220304#ent", "<e1>", "be", "inhibited", "by", "C2697944#ent", "<e2>", "or", "compactin", ",", "inhibitors", "of", "the", "synthesis", "of", "mevalonate", ",", "an", "intermediate", "of", "cholesterol", "biosynthesis"], "h": {"id": "C0220304", "name": "C0220304#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2697944", "name": "C2697944#ent", "pos": [15, 16]}}
{"token": ["The", "actions", "of", "this", "progesterone-stimulating", "factor", "(", "C2348113#ent", "<e1>", ")", "were", "characterized", "further", "by", "purifying", "it", "by", "sequential", "chromatographies", "C0062515#ent", "<e2>", ",", "copper", "chelating-Sepharose", "and", "Mono", "S", "columns"], "h": {"id": "C2348113", "name": "C2348113#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0062515", "name": "C0062515#ent", "pos": [19, 20]}}
{"token": ["All", "three", "C0086376#ent", "<e1>", "bound", "preferentially", "to", "distinct", "regions", "within", "the", "C1419599#ent", "<e2>", "thus", "are", "candidates", "for", "mediating", "pyrimidine", "tract-dependent", "branch", "site", "selection", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419599", "name": "C1419599#ent", "pos": [11, 12]}}
{"token": ["Mutations", "in", "the", "region", "of", "and", "affecting", "directly", "the", "predicted", "catalytic", "cysteine", "support", "the", "deduction", "that", "C2699876#ent", "<e1>", "is", "a", "C2717970#ent", "<e2>"], "h": {"id": "C2699876", "name": "C2699876#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [20, 21]}}
{"token": ["C0398650#ent", "<e1>", "an", "infrequent", "yet", "well-recognized", "complication", "of", "viral", "infections", "such", "as", "C0026780#ent", "<e2>", ",", "rubella", ",", "varicella", ",", "cytomegalovirus", ",", "parvovirus", "and", "infectious", "monunucleosis", "Epstein-Barr", "virus"], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026780", "name": "C0026780#ent", "pos": [12, 13]}}
{"token": ["Since", "C3273673#ent", "<e1>", "has", "been", "indicated", "as", "a", "potential", "C0079427#ent", "<e2>", "we", "also", "looked", "at", "its", "expression", "in", "tumours", "deriving", "from", "testicular", "germ", "cells", "TGCTs", ")", "."], "h": {"id": "C3273673", "name": "C3273673#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [9, 10]}}
{"token": ["Comparison", "of", "ETA", ",", "C3811132#ent", "<e1>", "and", "V8", "protease", "other", "members", "of", "the", "C1416671#ent", "<e2>", "little", "homology", "save", "for", "the", "immediate", "vicinity", "of", "the", "residues", "constituting", "the", "catalytic", "triad"], "h": {"id": "C3811132", "name": "C3811132#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "C1414057#ent", "<e1>", "is", "a", "key", "player", "in", "MM", "C0005940#ent", "<e2>", "that", "blocking", "C1414057#ent", "<e1>", "activity", "in", "myelomatous", "bones", "reduces", "osteolytic", "bone", "resorption", "increases", "bone", "formation", "and", "helps", "control", "MM", "growth", "."], "h": {"id": "C1414057", "name": "C1414057#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005940", "name": "C0005940#ent", "pos": [11, 12]}}
{"token": ["C1510471#ent", "<e1>", "to", "have", "little", "effect", "on", "C0052476#ent", "<e2>", "formation", "."], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0052476", "name": "C0052476#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "indicated", "that", "a", "continuous", "supply", "human", "C1416669#ent", "<e1>", "the", "circulation", "is", "sufficient", "to", "reduce", "blood", "pressure", "C1416670#ent", "<e2>", "via", "the", "intramuscular", "route", "may", "have", "significant", "implications", "in", "therapeutic", "applications"], "h": {"id": "C1416669", "name": "C1416669#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416670", "name": "C1416670#ent", "pos": [18, 19]}}
{"token": ["In", "an", "effort", "to", "identify", "the", "source", "of", "differential", "C1416669#ent", "<e1>", "excretion", ",", "we", "investigated", "the", "promoter", "of", "C1416670#ent", "<e2>", ",", "the", "tissue", "kallikrein", "gene"], "h": {"id": "C1416669", "name": "C1416669#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416670", "name": "C1416670#ent", "pos": [18, 19]}}
{"token": ["Twenty-seven", "C0013295#ent", "<e1>", "patients", "were", "treated", "with", "C0028978#ent", "<e2>", ",", "40", "mg", "daily", "for", "4", "weeks", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [7, 8]}}
{"token": ["The", "development", "of", "C0013295#ent", "<e1>", "gastric", "erosions", "by", "mepirizole", "was", "also", "potently", "inhibited", "by", "C0028978#ent", "<e2>", "at", "3", "-", "10", "mg/kg", "given", "orally", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [14, 15]}}
{"token": ["Consistent", "with", "these", "observations", ",", "the", "presence", "(", "C3540564#ent", "<e1>", ")", "or", "absence", "(", "rSKDelta59", ")", "of", "the", "C2987134#ent", "<e2>", "NH(2)-terminal", "peptide", "markedly", "altered", "fibrinolysis", "of", "human", "clots", "suspended", "in", "plasma", "."], "h": {"id": "C3540564", "name": "C3540564#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987134", "name": "C2987134#ent", "pos": [18, 19]}}
{"token": ["C0031190#ent", "<e1>", "and", "decreased", "inhaled", "NO", "responsiveness", "in", "C3542407#ent", "<e2>", "may", "involve", "decreased", "sGC", "activity", "."], "h": {"id": "C0031190", "name": "C0031190#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [8, 9]}}
{"token": ["Groups", "of", "five", "cows", "received", "C1161352#ent", "<e1>", ",", "scopolamine", "or", "C0043366#ent", "<e2>", "at", "dosages", "varying", "from", "0.01", "to", "0.20", "mg/kg", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0043366", "name": "C0043366#ent", "pos": [10, 11]}}
{"token": ["This", "study", "demonstrated", "that", "administration", "of", "C1161352#ent", "<e1>", ",", "scopolamine", "and", "C0043366#ent", "<e2>", "results", "in", "reticular", "atony", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0043366", "name": "C0043366#ent", "pos": [11, 12]}}
{"token": ["The", "same", "hierarchy", "of", "inhibitory", "potency", "as", "that", "against", "the", "C0027203#ent", "<e1>", "from", "other", "sources", ",", "triacsin", "C", "than", "C0146614#ent", "<e2>", "greater", "than", "triacsin", "D", "than", "or", "equal", "to", "triacsin", "B", "was", "observed", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0146614", "name": "C0146614#ent", "pos": [19, 20]}}
{"token": ["C1413259#ent", "<e1>", "activates", "Cdc2", "for", "entry", "into", "mitosis", "by", "dephosphorylating", "Thr", "C0041484#ent", "<e2>", "at", "the", "site", "of", "inhibitory", "phosphorylation", "."], "h": {"id": "C1413259", "name": "C1413259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041484", "name": "C0041484#ent", "pos": [11, 12]}}
{"token": ["Human", "tissue", "kallikrein-related", "peptidases", "KLK", ")", "are", "a", "family", "of", "15", "C1417679#ent", "<e1>", "located", "on", "chromosome", "19q13.4", "that", "encode", "secreted", "C0036734#ent", "<e2>", "trypsin-", "and/or", "chymotrypsin-like", "activity"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [20, 21]}}
{"token": ["After", "correction", ",", "the", "signals", "were", "found", "to", "be", "coherent", "between", "the", "C0235267#ent", "<e1>", "over", "both", "low-", "and", "high-frequency", "ranges", "irrespective", "of", "C0310298#ent", "<e2>", ",", "convergence", "or", "fixation", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [22, 23]}}
{"token": ["The", "initial", "clinical", "appearance", "the", "patient's", "C0011603#ent", "<e1>", "was", "atypical", "with", "resemblance", "to", "C0024137#ent", "<e2>"], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024137", "name": "C0024137#ent", "pos": [13, 14]}}
{"token": ["Production", "of", "PIP", "and", "PIP2", "may", "be", "important", "downstream", "signals", "these", "C0259479#ent", "<e1>", "are", "able", "to", "regulate", "the", "interaction", "of", "gelsolin", "and", "C0072074#ent", "<e2>", "with", "actin", "."], "h": {"id": "C0259479", "name": "C0259479#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0072074", "name": "C0072074#ent", "pos": [22, 23]}}
{"token": ["C0312380#ent", "<e1>", "the", "first", "C0027203#ent", "<e2>", "involved", "in", "biotin", "degradation", ",", "was", "purified", "from", "a", "cell-free", "extract", "a", "biotin-degrading", "bacterium", ",", "Mycoplana", "sp.", "No.", "166", "."], "h": {"id": "C0312380", "name": "C0312380#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}}
{"token": ["Furthermore", ",", "expression", "of", "a", "reporter", "gene", "by", "the", "authentic", "C3544029#ent", "<e1>", "promoter", "was", "induced", "in", "vegetative", "cells", "ectopic", "C0221406#ent", "<e2>", "of", "Mei4p", "."], "h": {"id": "C3544029", "name": "C3544029#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [19, 20]}}
{"token": ["It", "has", "been", "previously", "suggested", "that", "the", "C1421297#ent", "<e1>", "the", "apolipoprotein", "E", "APOE", ")", "C0017337#ent", "<e2>", "may", "have", "a", "protective", "effect", "AMD", "risk", "and", "that", "the", "e2", "allele", "increase", "disease", "risk"], "h": {"id": "C1421297", "name": "C1421297#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "indicate", "that", "C1416917#ent", "<e1>", "significantly", "decrease", "NK", ",", "C1538265#ent", "<e2>", "and", "CTL", "activities", "in", "vitro", "granzyme", "inhibition"], "h": {"id": "C1416917", "name": "C1416917#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1538265", "name": "C1538265#ent", "pos": [10, 11]}}
{"token": ["Clonogenic", "survival", "C1254351#ent", "<e1>", "Chinese", "hamster", "V79", "171", "cells", "incubated", "in", "suspension", "with", "C0078518#ent", "<e2>", "prior", "to", "gamma", "irradiation", "been", "determined", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0078518", "name": "C0078518#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "the", "mutant", "C1706112#ent", "<e1>", "suppressed", "the", "absolute", "transformation", "deficiency", "caused", "by", "the", "C1823283#ent", "<e2>", "mutation", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1823283", "name": "C1823283#ent", "pos": [14, 15]}}
{"token": ["We", "determined", "the", "relative", "contribution", "of", "C1335872#ent", "<e1>", "to", "IL-6", "signaling", "and", "actions", "in", "vivo", "the", "brain", "of", "C3540509#ent", "<e2>", "mice", "."], "h": {"id": "C1335872", "name": "C1335872#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540509", "name": "C3540509#ent", "pos": [18, 19]}}
{"token": ["Experiments", "were", "conducted", "to", "compare", "the", "food", "intake", "suppressant", "effects", "of", "the", "5-hydroxytryptamine", "(5-HT)1", "1", "-", "3-trifluoromethylphenylpiperazine", "hydrochloride", "(", "C0044180#ent", "<e1>", ")", "and", "5-methoxy-3-(1,2,3,6-tetrahydropyridinyl)1H", "indole", "(", "C0073661#ent", "<e2>", "following", "either", "peripheral", "or", "medial", "hypothalamic", "injections"], "h": {"id": "C0044180", "name": "C0044180#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0073661", "name": "C0073661#ent", "pos": [26, 27]}}
{"token": ["Second", ",", "saturating", "amounts", "of", "anti-mB7", "mAb", "do", "not", "significantly", "block", "binding", "C1831885#ent", "<e1>", "activated", "splenic", "C1456795#ent", "<e2>", "."], "h": {"id": "C1831885", "name": "C1831885#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [16, 17]}}
{"token": ["HERV-K", "encodes", "a", "protein", "of", "the", "Rev/Rex", "family", ",", "C3715179#ent", "<e1>", ",", "that", "supports", "cellular", "transformation", "binds", "the", "promyelocytic", "leukemia", "zinc", "finger", "C1538149#ent", "<e2>", ")", "protein", "implicated", "in", "spermatogenesis", "."], "h": {"id": "C3715179", "name": "C3715179#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [22, 23]}}
{"token": ["C0268450#ent", "<e1>", "GS", ")", "is", "a", "C0017361#ent", "<e2>", "salt-losing", "tubulopathy", "that", "is", "caused", "by", "mutations", "in", "the", "SLC12A3", "gene", "encodes", "the", "sodium-chloride", "co-transporter", "NCC", ")", "."], "h": {"id": "C0268450", "name": "C0268450#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [6, 7]}}
{"token": ["In", "the", "past", "decade", "our", "understanding", "of", "the", "etiology", "and", "pathophysiology", "of", "C0268450#ent", "<e1>", "an", "autosomal", "C0017361#ent", "<e2>", "salt-losing", "tubular", "disorder", "secondary", "hypokalemia", "has", "increased", "considerably", "through", "the", "achievements", "of", "molecular", "genetics", "cell", "physiology"], "h": {"id": "C0268450", "name": "C0268450#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [16, 17]}}
{"token": ["Recent", "work", "has", "implicated", "the", "NIMA", "(", "never", "in", "mitosis", ",", "gene", "A)-related", "kinase-6", "(", "C1417675#ent", "<e1>", ")", "as", "the", "enzyme", "that", "phosphorylates", "the", "hydrophobic", "motif", "C1419748#ent", "<e2>", "in", "vivo"], "h": {"id": "C1417675", "name": "C1417675#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419748", "name": "C1419748#ent", "pos": [26, 27]}}
{"token": ["When", "the", "Cox", "proportional", "hazards", "regression", "method", "was", "used", "to", "simultaneously", "adjust", "for", "age", ",", "histology", ",", "C1457887#ent", "<e1>", "and", "stage", ",", "elevated", "C0027203#ent", "<e2>", "levels", "still", "were", "correlated", "with", "short", "survival"], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [23, 24]}}
{"token": ["One", "of", "them", "died", "of", "C0042721#ent", "<e1>", "1", "mo", "and", "another", "of", "C0206061#ent", "<e2>", "4", "mo", "in", "CR", "."], "h": {"id": "C0042721", "name": "C0042721#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [12, 13]}}
{"token": ["Six", "of", "48", "patients", "had", "C1096458#ent", "<e1>", "the", "level", "of", "the", "C0029128#ent", "<e2>"], "h": {"id": "C1096458", "name": "C1096458#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029128", "name": "C0029128#ent", "pos": [11, 12]}}
{"token": ["This", "result", "stresses", "the", "diagnostic", "importance", "of", "the", "electrophysiologic", "studies", "sacral", "segmental", "innervation", "indicates", "further", "that", "in", "a", "comprehensive", "diagnostic", "protocol", "diabetic", "C0242350#ent", "<e1>", "the", "study", "of", "C1425041#ent", "<e2>", "should", "be", "performed", "only", "in", "patients", "with", "peripheral", "neuropathy"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1425041", "name": "C1425041#ent", "pos": [27, 28]}}
{"token": ["We", "show", "that", "C0669365#ent", "<e1>", "and", "phorbol", "12-myristate", "13-acetate-induced", "of", "soluble", "C0812237#ent", "<e2>", "(", "sAxl", ")", "involves", "the", "activity", "of", "disintegrin-like", "metalloproteinase", "10", "ADAM10", ")", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812237", "name": "C0812237#ent", "pos": [11, 12]}}
{"token": ["A", "17-year-old", "male", "patient", "with", "C0024796#ent", "<e1>", "admitted", "due", "to", "recurrent", "C0032326#ent", "<e2>", "had", "recurred", "totally", "11", "times", "during", "the", "past", "3", "years", "."], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0032326", "name": "C0032326#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "case", "of", "hypertensive", "urgency", "that", "ensued", "after", "a", "patient", "stabilized", "on", "C0009014#ent", "<e1>", "began", "taking", "C0049506#ent", "<e2>", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0049506", "name": "C0049506#ent", "pos": [18, 19]}}
{"token": ["Primary", "sequence", "analysis", "in", "vitro", "transcription/translation", "of", "ECPsp", "have", "revealed", "that", "it", "is", "a", "potential", "substrate", "for", "human", "C1424276#ent", "<e1>", "hSPP", ")", ",", "an", "C1842354#ent", "<e2>", "in", "endoplasmic", "reticulum"], "h": {"id": "C1424276", "name": "C1424276#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1842354", "name": "C1842354#ent", "pos": [24, 25]}}
{"token": ["Catalytic", "subunits", "the", "mammalian", "IMP", "complex", "were", "identified", "based", "on", "sequence", "conservation", "and", "functional", "complementation", ",", "and", "the", "novel", "sequence", "motif", "in", "C1424276#ent", "<e1>", "and", "NX(5)S", "in", "C1842354#ent", "<e2>", "distinguish", "the", "two", "catalytic", "subunits"], "h": {"id": "C1424276", "name": "C1424276#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1842354", "name": "C1842354#ent", "pos": [27, 28]}}
{"token": ["Moreover", ",", "CMEC", "expression", "of", "C1336938#ent", "<e1>", "was", "not", "influenced", "by", "the", "addition", "of", "3T3", "fibroblasts", "mouse", "C0669372#ent", "<e2>", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [17, 18]}}
{"token": ["C0860204#ent", "<e1>", "which", "may", "precede", "the", "C0037285#ent", "<e2>", "SJS", ",", "has", "been", "reported", "to", "occur", "in", "SJS", ",", "but", "the", "medical", "literature", "only", "10", "case", "reports", "this", "phenomenon", "(", "1", "-", "9", ")", "."], "h": {"id": "C0860204", "name": "C0860204#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037285", "name": "C0037285#ent", "pos": [6, 7]}}
{"token": ["The", "induction", "of", "C1334879#ent", "<e1>", "expression", "in", "mature", "degenerating", "spinal", "motor", "of", "humans", "and", "transgenic", "mice", "amyotrophic", "lateral", "sclerosis", "C1704945#ent", "<e2>", ")", "suggests", "a", "role", "of", "C1334879#ent", "<e1>", "in", "the", "progression", "of", "motor", "neuron", "disease", "MND", ")", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1334879", "name": "C1334879#ent", "pos": [3, 4]}}
{"token": ["However", ",", "attempts", "to", "modulate", "p75NTR-mediated", "neuronal", "death", "C1704945#ent", "<e1>", "models", "by", "downregulating", "or", "antagonizing", "C1334879#ent", "<e2>", "with", "synthetic", "peptides", "led", "to", "only", "modest", "results", "."], "h": {"id": "C1704945", "name": "C1704945#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334879", "name": "C1334879#ent", "pos": [15, 16]}}
{"token": ["Seven", "steroids", "and", "two", "C0010206#ent", "<e1>", "were", "isolated", "from", "the", "C0303762#ent", "<e2>", "the", "specie", "Cacalia", "tangutica", "of", "the", "family", "Compositae", "were", "collected", "in", "Minhe", "county", "Qinhai", "province", "of", "China", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0303762", "name": "C0303762#ent", "pos": [10, 11]}}
{"token": ["To", "explore", "the", "relationship", "between", "angiotensinogen", "(", "C1366631#ent", "<e1>", ")", "gene", "M235", "T", "and", "TCM", "syndrome", "type", "in", "C0085580#ent", "<e2>", "ET", ")", "patients", "."], "h": {"id": "C1366631", "name": "C1366631#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [18, 19]}}
{"token": ["These", "findings", "indicate", "that", "hyperglycemia", "and", "HG", "cause", "an", "activation", "and", "up-regulation", "of", "C1419266#ent", "<e1>", "in", "renal", "glomeruli", "in", "cultured", "MCs", ",", "which", "then", "stimulates", "C1706331#ent", "<e2>", "synthesis", "."], "h": {"id": "C1419266", "name": "C1419266#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [25, 26]}}
{"token": ["Isolated", "deficiencies", "of", "antithrombin", "III", "protein", "C", "C2002622#ent", "<e1>", "and", "plasminogen", "have", "been", "implicated", "as", "a", "cause", "of", "C0149871#ent", "<e2>"], "h": {"id": "C2002622", "name": "C2002622#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [18, 19]}}
{"token": ["Transient", "transfection", "of", "the", "deleted", "cAMP", "response", "element", "expression", "vector", "by", "pretreatment", "with", "C0298346#ent", "<e1>", "prior", "to", "C0006456#ent", "<e2>", "stimulation", "showed", "that", "the", "transcriptional", "response", "decreased", "compared", "to", "wild-type", "promoter", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006456", "name": "C0006456#ent", "pos": [17, 18]}}
{"token": ["C0014118#ent", "<e1>", "for", "5", "-", "10", "%", "of", "all", "cases", "of", "C0014121#ent", "<e2>", "with", "the", "tricuspid", "valve", "frequently", "affected", "than", "the", "pulmonary", "valve"], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0014121", "name": "C0014121#ent", "pos": [11, 12]}}
{"token": ["Interestingly", ",", "the", "majority", "of", "the", "newly", "synthesized", "C0019163#ent", "<e1>", "DNA", "genomes", "extensive", "G-to-A", "mutations", "in", "the", "presence", "of", "C1424926#ent", "<e2>", ",", "whereas", "no", "A3C-induced", "C0019163#ent", "<e1>", "RNA", "mutations", "were", "detected", "."], "h": {"id": "C1424926", "name": "C1424926#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [8, 9]}}
{"token": ["The", "population", "studied", "comprised", "62", "consecutive", "patients", "who", "rebled", "from", "C0017145#ent", "<e1>", "while", "participating", "in", "a", "controlled", "trial", "C0033497#ent", "<e2>", "for", "the", "prevention", "of", "rebleeding", "."], "h": {"id": "C0017145", "name": "C0017145#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [18, 19]}}
{"token": ["The", "formation", "of", "sporadic", "abdominal", "aortic", "aneurysm", "C1364818#ent", "<e1>", ")", "is", "explained", "by", "remodeling", "of", "the", "extracellular", "matrix", "C1417215#ent", "<e2>", ")", "and", "breakdown", "of", "structural", "components", "of", "the", "vascular", "wall"], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417215", "name": "C1417215#ent", "pos": [18, 19]}}
{"token": ["Two", "case", "reports", "presented", "of", "C0014544#ent", "<e1>", "due", "to", "C0158945#ent", "<e2>", "treated", "with", "human", "leukocyte", "gamma", "interferon"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0158945", "name": "C0158945#ent", "pos": [9, 10]}}
{"token": ["This", "indicates", "that", "C0025041#ent", "<e1>", "treatment", "of", "C0029408#ent", "<e2>", "the", "hands", "is", "significantly", "superior", "to", "placebo", "."], "h": {"id": "C0025041", "name": "C0025041#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [7, 8]}}
{"token": ["Quantitative", "ELISA", "showed", "that", ",", "compared", "with", "C1415793#ent", "<e1>", ",", "the", "agrin-like", "GBM", "C2987155#ent", "<e2>", "showed", "a", "sixfold", "higher", "molarity", "in", "crude", "glomerular", "extract", "."], "h": {"id": "C1415793", "name": "C1415793#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [13, 14]}}
{"token": ["Monoclonal", "antibodies", "C1415793#ent", "<e1>", "receptor", "binding", "activity", "from", "active", "C2987155#ent", "<e2>", "preparations", "."], "h": {"id": "C1415793", "name": "C1415793#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2987155", "name": "C2987155#ent", "pos": [9, 10]}}
{"token": ["Our", "findings", "that", "cyclic", "strain", "upregulates", "C1705939#ent", "<e1>", "mRNA", "expression", "but", "that", "shear", "stress", "downregulates", "this", "C0079429#ent", "<e2>", "in", "VSMCs", "provide", "an", "opportunity", "to", "elucidate", "signaling", "differences", "by", "which", "VSMCs", "respond", "to", "different", "mechanical", "forces"], "h": {"id": "C1705939", "name": "C1705939#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "with", "documented", "unilateral", "C0042594#ent", "<e1>", "the", "p14-n21", "potentials", "were", "preserved", "in", "the", "presence", "of", "C4021534#ent", "<e2>", "absent", "in", "those", "patients", "with", "partial", "or", "total", "vestibular", "loss"], "h": {"id": "C0042594", "name": "C0042594#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4021534", "name": "C4021534#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "NF-AB", "is", "considered", "a", "new", "candidate", "involved", "in", "C1522428#ent", "<e1>", "regulation", "of", "the", "rat", "C4283942#ent", "<e2>", "gene", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4283942", "name": "C4283942#ent", "pos": [16, 17]}}
{"token": ["Activation", "of", "C1955862#ent", "<e1>", "ADP", "required", "the", "presence", "of", "intracellular", "C1417500#ent", "<e2>", "+", "."], "h": {"id": "C1955862", "name": "C1955862#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [10, 11]}}
{"token": ["CDA", "I", "caused", "by", "mutations", "in", "the", "C3273707#ent", "<e1>", "encoding", "for", "C1413248#ent", "<e2>", "."], "h": {"id": "C3273707", "name": "C3273707#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413248", "name": "C1413248#ent", "pos": [11, 12]}}
{"token": ["The", "C0079429#ent", "<e1>", "for", "the", "C0022956#ent", "<e2>", "Pseudomonas", "putida", "the", "genes", "responsible", "for", "the", "activity", "of", "C0022956#ent", "<e2>", "methylglyoxal", "reductase", "Saccharomyces", "cerevisiae", "cloned", "and", "their", "structural", "and", "phenotypic", "characters", "studied", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022956", "name": "C0022956#ent", "pos": [5, 6]}}
{"token": ["The", "C0079429#ent", "<e1>", "responsible", "for", "the", "C0022956#ent", "<e2>", "activity", "in", "pGI", "318", "was", "recloned", "in", "pBR", "322", "a", "2.2", "kilobase", "Hin", "dIII", "fragment", "was", "designated", "pGI", "423", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022956", "name": "C0022956#ent", "pos": [6, 7]}}
{"token": ["Etiologic", "pathogens", "associated", "with", "C0077906#ent", "<e1>", "among", "patients", "with", "C0011847#ent", "<e2>", "include", "Klebsiella", "spp", ","], "h": {"id": "C0077906", "name": "C0077906#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "PAI-2", "can", "inhibit", "cell-bound", "C0078956#ent", "<e1>", "activity", "in", "vitro", "thus", "prevent", "C0016016#ent", "<e2>"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016016", "name": "C0016016#ent", "pos": [15, 16]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "C4025182#ent", "<e1>", "changes", "in", "hippocampal", "brain-derived", "neurotrophic", "factor", "BDNF", ")", "and", "neurotrophin-3", "(", "C1706578#ent", "<e2>", ")", "differ", "among", "rat", "strains", "exhibiting", "a", "range", "of", "voluntary", "wheel", "running", "activity", "."], "h": {"id": "C4025182", "name": "C4025182#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706578", "name": "C1706578#ent", "pos": [18, 19]}}
{"token": ["The", "mediator", "activated", "C0034343#ent", "<e1>", "activating", "the", "C0034346#ent", "<e2>", "not", "by", "inhibiting", "the", "pyruvate", "dehydrogenase", "kinase"], "h": {"id": "C0034343", "name": "C0034343#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034346", "name": "C0034346#ent", "pos": [7, 8]}}
{"token": ["C0385157#ent", "<e1>", "preferentially", "suppressed", "the", "production", "of", "C1415975#ent", "<e2>", "by", "peripheral", "blood", "mononuclear", "cells", "PBMC", ")", "in", "a", "dose-dependent", "manner", ",", "without", "inhibiting", "PBMC", "proliferation", "."], "h": {"id": "C0385157", "name": "C0385157#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [7, 8]}}
{"token": ["Trial", "of", "drug", "therapy", "C2745877#ent", "<e1>", "Cernilton", "and", "C0032912#ent", "<e2>", "did", "not", "restore", "voiding", "function"], "h": {"id": "C2745877", "name": "C2745877#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [8, 9]}}
{"token": ["Bartonella", "henselae", "initially", "been", "linked", "to", "bacillary", "angiomatosis", "BA", ")", ",", "a", "C0042373#ent", "<e1>", "commonly", "associated", "with", "human", "C0001175#ent", "<e2>", "other", "significant", "immunosuppression", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [18, 19]}}
{"token": ["Pre-treatment", "with", "prazosin", "caused", "a", "significant", "attenuation", "of", "the", "C0078569#ent", "<e1>", "induced", "5-HT", "effect", "the", "C1418482#ent", "<e2>", ",", "and", "a", "moderate", "increase", "in", "DA", "levels", "in", "the", "HIPP", "."], "h": {"id": "C0078569", "name": "C0078569#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [15, 16]}}
{"token": ["These", "molecular", "markers", "be", "used", "to", "identify", "C0018378#ent", "<e1>", "populations", "and", "to", "correlate", "C1868681#ent", "<e2>", "types", "and", "phylogenetic", "lineages", "identified", "by", "different", "methods", "."], "h": {"id": "C0018378", "name": "C0018378#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1868681", "name": "C1868681#ent", "pos": [13, 14]}}
{"token": ["CL", "intensities", "induced", "by", "C0018378#ent", "<e1>", "isolates", "of", "C1868681#ent", "<e2>", "types", "Ia-2", ",", "Ia-3", "and", "III-3", "were", "lower", "than", "those", "of", "the", "other", "C1868681#ent", "<e2>", "types", "of", "the", "same", "serotype", "."], "h": {"id": "C0018378", "name": "C0018378#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1868681", "name": "C1868681#ent", "pos": [8, 9]}}
{"token": ["All", "of", "the", "C0991617#ent", "<e1>", "tested", "produced", "a", "dose-dependent", "C0026961#ent", "<e2>", "of", "long", "duration"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026961", "name": "C0026961#ent", "pos": [9, 10]}}
{"token": ["In", "the", "C1839730#ent", "<e1>", "of", "the", "CGM2", "gene", "the", "C1335836#ent", "<e2>", "and", "the", "TM30pl", "genes", ",", "which", "showed", "highly", "colon", "specific", "expression", "patterns", ",", "the", "consensus", "sequences", "E", "boxes", "commonly", "observed", "."], "h": {"id": "C1839730", "name": "C1839730#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335836", "name": "C1335836#ent", "pos": [9, 10]}}
{"token": ["The", "detection", "limits", "for", "FMOC", "derivatives", "of", "proline", ",", "trans-4-hydroxyproline", ",", "cis-4-hydroxyproline", ",", "pyroglutamic", "acid", "3,4-dehydroproline", ",", "thiaproline", ",", "C0030817#ent", "<e1>", "acetone", "adduct", "and", "C0282526#ent", "<e2>", "in", "the", "low", "femtomole", "range", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0282526", "name": "C0282526#ent", "pos": [24, 25]}}
{"token": ["The", "two", "pharmacologically", "active", "preparations", "were", "C0058652#ent", "<e1>", "(", "dextropropoxyphene", ",", "acetylsalicylic", "acid", "phenazone", ",", "caffeine", "and", "C0609980#ent", "<e2>", ")", "and", "Astra", "2167", "dextropropoxyphene", "and", "acetylsalicylic", "acid", "."], "h": {"id": "C0058652", "name": "C0058652#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0609980", "name": "C0609980#ent", "pos": [17, 18]}}
{"token": ["The", "induction", "of", "RAR", "beta", "expression", "by", "the", "ciglitazone", "and", "C0254507#ent", "<e1>", "combination", "was", "diminished", "by", "a", "PPAR", "gamma-selective", "antagonist", ",", "C0045287#ent", "<e2>"], "h": {"id": "C0254507", "name": "C0254507#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0045287", "name": "C0045287#ent", "pos": [21, 22]}}
{"token": ["277", ",", "6667", "-", "6675", "]", "that", "C1420357#ent", "<e1>", "activity", "is", "C0669365#ent", "<e2>", "secreted", "by", "vascular", "endothelial", "cells"], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["C0752224#ent", "<e1>", "was", "higher", "in", "taurine-treated", "animals", "than", "in", "the", "rats", "C0342895#ent", "<e2>", "only", "fructose", "."], "h": {"id": "C0752224", "name": "C0752224#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [11, 12]}}
{"token": ["A", "clone", "specific", "to", "the", "functional", "stage", "of", "C0010093#ent", "<e1>", "found", "to", "encode", "the", "C0172956#ent", "<e2>", "gene", "and", "the", "stage-specific", "expression", "in", "luteinizing", "tissue", "was", "confirmed", "by", "Northern", "blot", "analysis"], "h": {"id": "C0010093", "name": "C0010093#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0172956", "name": "C0172956#ent", "pos": [14, 15]}}
{"token": ["WHI-05", "and", "WHI-07", "were", "formulated", "via", "a", "C0221777#ent", "<e1>", "gel-microemulsion", "for", "intravaginal", "use", "as", "potential", "C0376565#ent", "<e2>"], "h": {"id": "C0221777", "name": "C0221777#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376565", "name": "C0376565#ent", "pos": [15, 16]}}
{"token": ["C0020306#ent", "<e1>", "and", "C0016229#ent", "<e2>", "prolonged", "ventricular", "conduction", "C0016229#ent", "<e2>", "had", "a", "greater", "effect", "at", "the", "His-Purkinje", "level", "."], "h": {"id": "C0020306", "name": "C0020306#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016229", "name": "C0016229#ent", "pos": [3, 4]}}
{"token": ["However", ",", "four", "genes", ",", "pyridoxal", "kinase", "heat", "shock", "protein", "10", "C1415790#ent", "<e1>", ")", ",", "antigen", "identified", "by", "monoclonal", "antibodies", "4F2", "4F2", ")", "and", "C1417547#ent", "<e2>", "were", "downregulated", "by", "SNAP", "in", "presence", "of", "AP-1", "."], "h": {"id": "C1415790", "name": "C1415790#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417547", "name": "C1417547#ent", "pos": [24, 25]}}
{"token": ["Aortobronchial", "fistula", "secondary", "to", "C0162872#ent", "<e1>", "an", "unusual", "cause", "of", "C0019079#ent", "<e2>", "."], "h": {"id": "C0162872", "name": "C0162872#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019079", "name": "C0019079#ent", "pos": [10, 11]}}
{"token": ["Western", "blot", "analysis", "that", "ISL", "increased", "the", "levels", "of", "membrane-bound", "Fas", "ligand", "C1706006#ent", "<e1>", ")", ",", "Fas", ",", "cleaved", "casapse-8", ",", "truncated", "Bid", "C3641819#ent", "<e2>", ")", ",", "Bax", "and", "Bad", "in", "DU145", "cells", "(", "P<.05", ")", "."], "h": {"id": "C1706006", "name": "C1706006#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3641819", "name": "C3641819#ent", "pos": [23, 24]}}
{"token": ["Dual", "reporter", "genes", "encoding", "Renilla", "luciferase", "Rluc", ")", "and", "neomycin", "phosphotransferase", "C1366752#ent", "<e1>", ")", ",", "were", "engineered", "into", "a", "C1096184#ent", "<e2>", "subgenomic", "replicon", ",", "resulting", "in", "Rluc/NeoRep", "."], "h": {"id": "C1366752", "name": "C1366752#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1096184", "name": "C1096184#ent", "pos": [19, 20]}}
{"token": ["The", "concentration", "of", "C1367482#ent", "<e1>", "(", "1", "-", "7", ")", "and", "Ang", "II", "the", "C0011947#ent", "<e2>", "good", "correlation", "to", "that", "of", "Ang", "I", "a", "MD", "perfusate", "(", "20", "-", "100", "microM", ")", "."], "h": {"id": "C1367482", "name": "C1367482#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011947", "name": "C0011947#ent", "pos": [14, 15]}}
{"token": ["Nitric", "oxide", "NO", ")", "is", "a", "C1418656#ent", "<e1>", "vascular", "function", "and", "its", "overproduction", "by", "C1533698#ent", "<e2>", "iNOS", ")", "in", "inflammatory", "conditions", "an", "important", "role", "in", "the", "pathogenesis", "of", "vascular", "diseases"], "h": {"id": "C1418656", "name": "C1418656#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [14, 15]}}
{"token": ["In", "terms", "of", "nucleotide", "and", "deduced", "amino", "acid", "sequence", "C0020289#ent", "<e1>", "highly", "similar", "to", "C1334064#ent", "<e2>", "but", "differs", "from", "C1334064#ent", "<e2>", "terms", "of", "its", "catalytic", "activity", "tissue", "distribution"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334064", "name": "C1334064#ent", "pos": [14, 15]}}
{"token": ["The", "final", "section", "of", "this", "work", "investigates", "the", "possible", "origins", "of", "this", "modification", "and", "evidence", "is", "shown", "that", "C0007075#ent", "<e1>", "another", "basic", "C3265462#ent", "<e2>", "causes", "this", "variation", "."], "h": {"id": "C0007075", "name": "C0007075#ent", "pos": [18, 19]}, "relation": "structural_class_of", "t": {"id": "C3265462", "name": "C3265462#ent", "pos": [22, 23]}}
{"token": ["C1333877#ent", "<e1>", "are", "a", "subfamily", "of", "C2717971#ent", "<e2>", "in", "the", "pathogenesis", "of", "many", "inflammatory", "disorders"], "h": {"id": "C1333877", "name": "C1333877#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", "a", "C0033681#ent", "<e1>", "related", "to", "the", "products", "of", "the", "src", "family", "C0029016#ent", "<e2>", ",", "is", "modified", "in", "Burkitt", "lymphoma", "cells"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [15, 16]}}
{"token": ["Some", "C0033681#ent", "<e1>", "encoded", "by", "C0029016#ent", "<e2>", "and", "have", "been", "implicated", "in", "melanoma", "genesis", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [5, 6]}}
{"token": ["Upon", "stimulation", "of", "secretion", "by", "corticotropin-releasing", "factor", "a", "C3536829#ent", "<e1>", "or", "barium", "ions", "secretion", "of", "PAM", "activity", ",", "C1413668#ent", "<e2>", "and", "immunoactive", "hormone", "rose", "in", "parallel", "."], "h": {"id": "C3536829", "name": "C3536829#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413668", "name": "C1413668#ent", "pos": [18, 19]}}
{"token": ["In", "conclusion", ",", "alanine", "is", "effective", "for", "the", "treatment", "of", "experimental", "C0162557#ent", "<e1>", "probably", "caused", "by", "promotion", "of", "C2744579#ent", "<e2>", "synthesis", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [18, 19]}}
{"token": ["The", "high-affinity", "binding", "site", "for", "C1705556#ent", "<e1>", "of", "the", "C0282109#ent", "<e2>", "of", "cAMP-dependent", "protein", "kinase", "type", "I", "from", "rabbit", "skeletal", "muscle", "been", "investigated", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0282109", "name": "C0282109#ent", "pos": [9, 10]}}
{"token": ["We", "have", "examined", "the", "effect", "of", "C1705526#ent", "<e1>", "inactivation", "on", "atherogenesis", "in", "apoE-knockout", "mice", ",", "an", "animal", "model", "C0003850#ent", "<e2>", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [18, 19]}}
{"token": ["The", "strongest", "C3272518#ent", "<e1>", "obtained", "so", "far", "had", "a", "high", "Young's", "modulus", "1", "C0078956#ent", "<e2>", "but", "could", "only", "be", "produced", "in", "gram", "scale", "quantities", "."], "h": {"id": "C3272518", "name": "C3272518#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [13, 14]}}
{"token": ["The", "C0248813#ent", "<e1>", "JNK", ")", "activation", "occurs", "after", "islet", "isolation", "oxidative", "stress", "and", "proinflammatory", "cytokine", "C0730321#ent", "<e2>", ")", "exposure", "to", "beta-cells", "."], "h": {"id": "C0248813", "name": "C0248813#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0730321", "name": "C0730321#ent", "pos": [15, 16]}}
{"token": ["The", "AT1-receptor", "antagonist", "can", "inhibit", "protooncogenes", "(", "C0087140#ent", "<e1>", ",", "c-jun", "and", "Egr-1", ")", "and", "C1367472#ent", "<e2>", "in", "rat", "balloon-injured", "artery", ",", "which", "is", "associated", "with", "inhibition", "of", "neointima", "formation", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367472", "name": "C1367472#ent", "pos": [15, 16]}}
{"token": ["In", "addition", "to", "IRP2", ",", "C1412126#ent", "<e1>", "serves", "as", "sensor", "of", "reactive", "oxygen", "species", "C0812281#ent", "<e2>", ")", "."], "h": {"id": "C1412126", "name": "C1412126#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [14, 15]}}
{"token": ["The", "expression", "of", "C0672708#ent", "<e1>", "is", "initially", "down-regulated", "in", "pulmonary", "hypoplasia", "associated", "with", "C3542407#ent", "<e2>", "and", "peaks", "instead", "during", "the", "late", "canalicular", "stage", "."], "h": {"id": "C0672708", "name": "C0672708#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [13, 14]}}
{"token": ["Many", "tau-positive", "nerve", "cells", "in", "brainstem", "and", "spinal", "cord", "strongly", "immunoreactive", "for", "interleukin-1beta", "and", "C0387583#ent", "<e1>", ",", "indicating", "induction", "and", "overproduction", "of", "proinflammatory", "cytokines", "and", "C0014442#ent", "<e2>", "."], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [25, 26]}}
{"token": ["In", "a", "prospective", "study", "authors", "analyzed", "the", "relationship", "between", "C4283758#ent", "<e1>", "and", "the", "findings", "on", "diffusion-weighted", "magnetic", "resonance", "imaging", "DWI", ")", "in", "C0038454#ent", "<e2>", "patients", "."], "h": {"id": "C4283758", "name": "C4283758#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [22, 23]}}
{"token": ["Though", "thought", "to", "act", "primarily", "in", "the", "cytoplasm", ",", "we", "use", "biochemical", "fractionation", "with", "immunocytochemistry", "to", "verify", "the", "nuclear", "expression", "C0250414#ent", "<e1>", "and", "its", "interaction", "with", "C1705330#ent", "<e2>", "."], "h": {"id": "C0250414", "name": "C0250414#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1705330", "name": "C1705330#ent", "pos": [26, 27]}}
{"token": ["Cimetidine", "and", "C0004259#ent", "<e1>", "failed", "to", "reduce", "C0341177#ent", "<e2>", "whereas", "prostaglandin", "E2", "reduced", "the", "severity", "of", "the", "mucosal", "lesions", "respect", "to", "control", "values", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0341177", "name": "C0341177#ent", "pos": [7, 8]}}
{"token": ["The", "LIM", "homeobox", "genes", "of", "the", "C1425514#ent", "<e1>", "group", ",", "Lhx3", "and", "C3273822#ent", "<e2>", ",", "are", "critical", "for", "normal", "development"], "h": {"id": "C1425514", "name": "C1425514#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273822", "name": "C3273822#ent", "pos": [12, 13]}}
{"token": ["CD43-mediated", "homotypic", "aggregation", "T", "lymphocytes", "the", "participation", "of", "Src", "kinases", "phospholipase", "C-gamma2", "C1259877#ent", "<e1>", "phosphatidylinositol-3", "kinase", "as", "well", "as", "extracellular-regulated", "kinase", "1/2", "C1366876#ent", "<e2>", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [22, 23]}}
{"token": ["The", "presence", "of", "human", "C1418424#ent", "<e1>", "and", "rat", "C1447683#ent", "<e2>", "transcripts", "in", "lung", "was", "confirmed", "by", "reverse", "transcriptase-PCR"], "h": {"id": "C1418424", "name": "C1418424#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447683", "name": "C1447683#ent", "pos": [8, 9]}}
{"token": ["The", "deduced", "amino", "acid", "sequence", "C1418424#ent", "<e1>", "was", "the", "same", "as", "the", "C-terminal", "823-residue", "sequence", "of", "C1447683#ent", "<e2>", "and", "PDE5A2", "."], "h": {"id": "C1418424", "name": "C1418424#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447683", "name": "C1447683#ent", "pos": [16, 17]}}
{"token": ["C3540022#ent", "<e1>", "be", "employed", "for", "computer", "modelling", "the", "active", "site", "C0026455#ent", "<e2>", "B.", "Competitive", "fully", "reversible", "C3540022#ent", "<e1>", "rigid", "structure", "limited", "number", "of", "conformers", "are", "preferential", "compounds", "for", "these", "studies", "."], "h": {"id": "C0026455", "name": "C0026455#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540022", "name": "C3540022#ent", "pos": [0, 1]}}
{"token": ["The", "ratio", "of", "C0211797#ent", "<e1>", "RTH-1", "was", "also", "shown", "to", "be", "critical", "for", "both", "C3540790#ent", "<e2>", "to", "work", "together", "efficiently", "."], "h": {"id": "C0211797", "name": "C0211797#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [14, 15]}}
{"token": ["In", "C.", "glomerata", ",", "the", "C2926735#ent", "<e1>", "of", "this", "searching", "behavior", "at", "the", "C0030499#ent", "<e2>", "leaf", "edge", "was", "significantly", "shorter", "on", "all84", "plants", "than", "on", "wt", "plants", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030499", "name": "C0030499#ent", "pos": [13, 14]}}
{"token": ["Results", "from", "animal", "models", "a", "few", "preliminary", "clinical", "trials", "that", "this", "class", "of", "drugs", "may", "also", "offer", "significant", "potential", "for", "reducing", "the", "neuronal", "damage", "by", "C0948008#ent", "<e1>", "head", "trauma", "and", "perhaps", "certain", "C0751870#ent", "<e2>"], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [32, 33]}}
{"token": ["Transgenic", "mouse", "and", "cell", "models", "recently", "been", "developed", "to", "test", "the", "role", "of", "C1335837#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0178664#ent", "<e2>", "with", "and", "without", "diabetes", "."], "h": {"id": "C1335837", "name": "C1335837#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [19, 20]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "the", "clinical", "and", "histological", "efficacy", "of", "C0022957#ent", "<e1>", "in", "patients", "with", "inflammatory", "bowel", "disease", "C0021390#ent", "<e2>", ")", ",", "for", "which", "probiotic", "therapy", "promising", "results", "."], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [23, 24]}}
{"token": ["In", "this", "study", "the", "distribution", "of", "C0086376#ent", "<e1>", "involved", "with", "C0812305#ent", "<e2>", "cellular", "differentiation", "bladder", "impermeability", "in", "urothelial", "biopsies", "explored", "by", "the", "immunohistochemical", "assessment", "of", "E-cadherin", ",", "ZO-1", ",", "uroplakin", "and", "chondroitin", "sulfate"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812305", "name": "C0812305#ent", "pos": [10, 11]}}
{"token": ["Cyclooxygenase-2", "(", "COX-2", ")", "represents", "the", "inducible", "key", "C0014442#ent", "<e1>", "of", "arachidonic", "acid", "metabolism", "and", "contributes", "to", "the", "pathogenesis", "of", "C0030920#ent", "<e2>", "gastric", "cancer"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030920", "name": "C0030920#ent", "pos": [20, 21]}}
{"token": ["The", "introduction", "of", "mutation", "D119N", "(", "or", "its", "C1334043#ent", "<e1>", ")", "in", "the", "NKxD", "nucleotide", "binding", "motif", "various", "C0812284#ent", "<e2>", "constitutively", "activated", "or", "dominant-negative", "effects", ",", "depending", "on", "the", "system", "and", "assay", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0812284", "name": "C0812284#ent", "pos": [18, 19]}}
{"token": ["After", "the", "C0006938#ent", "<e1>", "delta", "RI", "decreased", "significantly", "in", "the", "C4049883#ent", "<e2>", "P", "<", "0.05", ")", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4049883", "name": "C4049883#ent", "pos": [10, 11]}}
{"token": ["Naloxone", "0.2", "mg/kg", "abolished", "the", "C0003289#ent", "<e1>", "effects", "of", "morphine", "and", "C0023586#ent", "<e2>", "and", ",", "when", "given", "alone", ",", "increased", "sympathetic", "impulse", "frequency", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023586", "name": "C0023586#ent", "pos": [11, 12]}}
{"token": ["Among", "treatment", "related", "symptoms", ",", "the", "combination", "of", "abdominal", "cramps", "vomiting", ",", "C0151594#ent", "<e1>", "vomiting", "alone", "and", "C0746674#ent", "<e2>", "significantly", "higher", "the", "malnourished", "."], "h": {"id": "C0151594", "name": "C0151594#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0746674", "name": "C0746674#ent", "pos": [17, 18]}}
{"token": ["C0034931#ent", "<e1>", "CRPS1", ")", "involves", "cortical", "abnormalities", "to", "those", "observed", "in", "C3495442#ent", "<e2>", "after", "stroke", "."], "h": {"id": "C0034931", "name": "C0034931#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3495442", "name": "C3495442#ent", "pos": [11, 12]}}
{"token": ["C0669516#ent", "<e1>", "mimetic", ",", "a", "potent", "scavenger", "of", "superoxide", "anions", "prevented", "IH-induced", "C1706383#ent", "<e2>", ",", "AP-1", "and", "TH", "activations", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [12, 13]}}
{"token": ["These", "proteins", "were", "liver", "type", "aldolase", "tropomyosin", "beta-chain", "C0064317#ent", "<e1>", ",", "enoyl-CoA", "hydratase", "albumin", ",", "smoothelin", ",", "ferritin", "light", "chain", "and", "C0003762#ent", "<e2>"], "h": {"id": "C0064317", "name": "C0064317#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003762", "name": "C0003762#ent", "pos": [21, 22]}}
{"token": ["To", "examine", "the", "mRNA", "expression", "of", "the", "linker", "for", "activation", "of", "T", "cell", "LAT", ")", "and", "its", "upstream", "regulatory", "factors", "C1706351#ent", "<e1>", ",", "Lck", "and", "ZAP-70", ")", "in", "the", "peripheral", "blood", "T", "cells", "C0004096#ent", "<e2>", "patients", "."], "h": {"id": "C1706351", "name": "C1706351#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [33, 34]}}
{"token": ["In", "contrast", ",", "seizures", "induced", "by", "intracerebral", "injection", "of", "benzyl", "penicillin", "antagonised", "by", "chlordiazepoxide", ",", "phenobarbital", ",", "C0037567#ent", "<e1>", ",", "ethosuximide", "and", "C0041038#ent", "<e2>", ",", "but", "not", "by", "phenytoin", "or", "muscimol", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0041038", "name": "C0041038#ent", "pos": [22, 23]}}
{"token": ["Acetylcholinesterase", "staining", "observed", "in", "the", "endplate", "region", "of", "mutant", "muscle", "C1417775#ent", "<e1>", "onwards", ",", "but", "not", "as", "dense", "and", "confined", "to", "C0015230#ent", "<e2>", "as", "in", "controls", "."], "h": {"id": "C1417775", "name": "C1417775#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [21, 22]}}
{"token": ["alpha-blockers", "(", "phenoxybenzamine", "and", "C0031448#ent", "<e1>", ")", "and", "monoamine", "oxidase", "MAO", ")", "inhibitor", "(", "C0022059#ent", "<e2>", ")", "produced", "an", "increased", "accumulation", "of", "5-HT", "fluorescence", "the", "apical", "regions", "of", "acinar", "cells", "the", "zymogen", "granules", "stored", "."], "h": {"id": "C0031448", "name": "C0031448#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022059", "name": "C0022059#ent", "pos": [14, 15]}}
{"token": ["Treatment", "with", "the", "C1268567#ent", "<e1>", "geldanamycin", "blocked", "nuclear", "accumulation", "C3537327#ent", "<e2>", "with", "heat", "shock"], "h": {"id": "C1268567", "name": "C1268567#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537327", "name": "C3537327#ent", "pos": [9, 10]}}
{"token": ["Rats", "familiar", "with", "the", "behavioral", "strategies", "involved", "in", "the", "C0310298#ent", "<e1>", "performed", "normally", "under", "C0000254#ent", "<e2>", "."], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0000254", "name": "C0000254#ent", "pos": [14, 15]}}
{"token": ["A", "young", "woman", "with", "a", "lipodystrophic", "form", "of", "C0011849#ent", "<e1>", ",", "hypertriglyceridemia", ",", "and", "severe", "C0000889#ent", "<e2>", "placed", "on", "a", "diet", "with", "fat", "supplementation", "the", "form", "of", "omega-3-fatty-acid-rich", "fish", "oil", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000889", "name": "C0000889#ent", "pos": [15, 16]}}
{"token": ["A", "case", "is", "presented", "with", "C0029888#ent", "<e1>", "and", "subsequent", "tympanogenic", "labyrinthitis", "extradural", "abscess", "and", "C0025289#ent", "<e2>"], "h": {"id": "C0029888", "name": "C0029888#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [14, 15]}}
{"token": ["C1334982#ent", "<e1>", "models", "for", "C0001175#ent", "<e2>", "AIDS", ")", "are", "important", "for", "studies", "of", "prevention", "and", "intervention", "strategies", "."], "h": {"id": "C1334982", "name": "C1334982#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [4, 5]}}
{"token": ["It", "is", "an", "opportunistic", "pathogen", "mainly", "acute", "cystitis", "C0520575#ent", "<e1>", ",", "encrusted", "cystitis", ",", "and", "C0034183#ent", "<e2>"], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034183", "name": "C0034183#ent", "pos": [15, 16]}}
{"token": ["Small", "C0018296#ent", "<e1>", "activation", "was", "not", "mediated", "by", "the", "osmotic", "stimulation", "C0282625#ent", "<e2>", "heterotrimeric", "G", "proteins", "or", "phosphatidylinositol", "3-kinase"], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [11, 12]}}
{"token": ["Several", "phosphoproteins", "(", "20", ",", "25", ",", "56", ",", "and", "165", "kilodaltons", ")", "showed", "differences", "in", "phosphorylation", "in", "response", "to", "C3539645#ent", "<e1>", "activators", "applied", "to", "intact", "nervous", "systems", "to", "isolated", "C0235267#ent", "<e2>", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [30, 31]}}
{"token": ["The", "C3540726#ent", "<e1>", "prednisolone", "or", "dexamethasone", "administered", "simultaneously", "with", "C0018983#ent", "<e2>", "(", "HC-3", ")", "by", "i.p", "."], "h": {"id": "C3540726", "name": "C3540726#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018983", "name": "C0018983#ent", "pos": [9, 10]}}
{"token": ["Their", "study", "will", "undoubtedly", "yield", "a", "C0221232#ent", "<e1>", "of", "new", "information", "on", "the", "function", "of", "C0072522#ent", "<e2>", "and", "of", "their", "carbohydrate", "moiety"], "h": {"id": "C0221232", "name": "C0221232#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [15, 16]}}
{"token": ["The", "C1705378#ent", "<e1>", "-", "-MALT1", "fusion", "transcript", "was", "not", "detected", "in", "C0744310#ent", "<e2>", "mucosal", "DLBCL", "but", "was", "found", "in", "25", "of", "72", "(", "35", "%", ")", "MALT", "lymphomas", "various", "sites", "."], "h": {"id": "C1705378", "name": "C1705378#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0744310", "name": "C0744310#ent", "pos": [11, 12]}}
{"token": ["We", "found", "considerable", "intersubject", "variability", "in", "early", "C0282556#ent", "<e1>", "responses", "to", "C1414143#ent", "<e2>", "ABCTs", "."], "h": {"id": "C0282556", "name": "C0282556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414143", "name": "C1414143#ent", "pos": [11, 12]}}
{"token": ["The", "treatment", "of", "C0333014#ent", "<e1>", "still", "difficult", "even", "though", "C0451641#ent", "<e2>", "treatment", "can", "now", "be", "performed", "by", "endourology", "and", "extracorporeal", "shock-wave", "lithotripsy", "ESWL", ")", "without", "open", "surgery"], "h": {"id": "C0333014", "name": "C0333014#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "in", "most", "cases", "of", "C0333014#ent", "<e1>", "well", "as", "other", "C0451641#ent", "<e2>", ",", "ESWL", "monotherapy", "seemed", "to", "be", "more", "effective", "and", "safe", "than", "combined", "therapy", "of", "PNL", "and", "ESWL", "."], "h": {"id": "C0333014", "name": "C0333014#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [11, 12]}}
{"token": ["Hence", ",", "the", "regulation", "of", "these", "C1417679#ent", "<e1>", ",", "normally", "regulated", "by", "environmental", "cues", "has", "been", "usurped", "by", "C0017373#ent", "<e2>", ",", "presumably", "as", "an", "adaptation", "to", "the", "challenging", "host", "environment", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017373", "name": "C0017373#ent", "pos": [18, 19]}}
{"token": ["We", "have", "recently", "demonstrated", "in", "mouse", "xenograft", "models", "fascin", "contributes", "to", "tumour", "development", "metastasis", "through", "its", "dual", "C1420280#ent", "<e1>", "and", "active", "C3710929#ent", "<e2>", "activities", "."], "h": {"id": "C1420280", "name": "C1420280#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3710929", "name": "C3710929#ent", "pos": [21, 22]}}
{"token": ["Antibacterial", "properties", "C0023660#ent", "<e1>", "were", "compared", "with", "those", "of", "C0053114#ent", "<e2>", "or", "tetracaine", ",", "either", "in", "current", "commercial", "eye", "lotions", "or", "in", "extemporaneous", "solutions", "."], "h": {"id": "C0023660", "name": "C0023660#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0053114", "name": "C0053114#ent", "pos": [9, 10]}}
{"token": ["Binding", "of", "the", "C1335440#ent", "<e1>", "to", "SV40", "DNA", "fragments", "the", "presence", "of", "increasing", "concentrations", "of", "C1412125#ent", "<e2>", "indicated", "a", "preferential", "binding", "to", "two", "restriction", "fragments", "compared", "to", "the", "others", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [15, 16]}}
{"token": ["Twelve", "C0079941#ent", "<e1>", "are", "new", ",", "two", "of", "which", "are", "most", "likely", "C1539696#ent", "<e2>", "leaving", "ten", "C0079941#ent", "<e1>", "of", "unknown", "function", "."], "h": {"id": "C1539696", "name": "C1539696#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [1, 2]}}
{"token": ["We", "report", "the", "case", "of", "a", "patient", "previously", "diagnosed", "with", "C1417325#ent", "<e1>", "later", "presented", "with", "ANA", "positivity", "and", "antiphospholipid", "antibodies", "C0263401#ent", "<e2>", "and", "deep", "venous", "thrombosis", "leading", "her", "to", "be", "characterized", "as", "having", "lupoid", "sclerosis"], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0263401", "name": "C0263401#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "this", "study", "investigated", "the", "effects", "of", "C0012544#ent", "<e1>", "BMD", "and", "bone", "strength", "rats", "treated", "with", "aromatase", "inhibitor", "C0246421#ent", "<e2>", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0246421", "name": "C0246421#ent", "pos": [19, 20]}}
{"token": ["This", "disease", "has", "also", "been", "associated", "with", "C0014130#ent", "<e1>", "Cushing's", "syndrome", "hypoparathyroidism", ",", "hypothyroidism", ",", "hyperthyroidism", "and", "C2103602#ent", "<e2>"], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C2103602", "name": "C2103602#ent", "pos": [17, 18]}}
{"token": ["Appropriate", "education", "should", "be", "given", "on", "C3179011#ent", "<e1>", "avoidance", "and", "C0024530#ent", "<e2>", "prophylaxis", "."], "h": {"id": "C3179011", "name": "C3179011#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [10, 11]}}
{"token": ["While", "Na(+", ")", "-dependent", "acid", "extrusion", "entirely", "inhibited", "by", "HOE694", "in", "C3495427#ent", "<e1>", "untreated", "cells", ",", "the", "operation", "of", "both", "NHE1", "and", "C1420234#ent", "<e2>", "was", "detected", "in", "cells", "exposed", "to", "C3495427#ent", "<e1>", "."], "h": {"id": "C1420234", "name": "C1420234#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3495427", "name": "C3495427#ent", "pos": [11, 12]}}
{"token": ["C0242889#ent", "<e1>", "phenoxybenzamine", ",", "total-body", "catecholamine", "depletion", "by", "reserpine", ",", "and", "C3536867#ent", "<e2>", "trimethaphan", "camphorsulfonate", "all", "inhibited", "the", "rise", "in", "arterial", "pressure", "but", "beta-adrenergic", "blockade", "propranolol", "did", "not", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536867", "name": "C3536867#ent", "pos": [11, 12]}}
{"token": ["Tilt", "table", "testing", "now", "an", "established", "tool", "both", "for", "diagnosis", "of", "this", "C0039082#ent", "<e1>", "and", "for", "guiding", "therapy", "with", "beta", "blockers", "C0012702#ent", "<e2>", ",", "theophylline", ",", "or", "alpha-agonists", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012702", "name": "C0012702#ent", "pos": [21, 22]}}
{"token": ["Proper", "management", "of", "uninvestigated", "C0013395#ent", "<e1>", "is", "a", "challenging", "C1416596#ent", "<e2>", "for", "any", "clinician", "."], "h": {"id": "C0013395", "name": "C0013395#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [9, 10]}}
{"token": ["The", "first", "part", "of", "this", "article", "deals", "with", "interactions", "between", "C1562036#ent", "<e1>", "marker", "compounds", "theophylline", ",", "midazolam", ",", "C3540800#ent", "<e2>", ",", "doxorubicin", ",", "oral", "hypoglycaemics", "and", "cardiac", "drugs"], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540800", "name": "C3540800#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "C0030071#ent", "<e1>", "drops", ",", "commonly", "used", "in", "acute", "rhinitis", "C0037199#ent", "<e2>", ",", "interfere", "with", "normal", "defense", "mechanisms", "during", "bacterially", "induced", "C0037199#ent", "<e2>", ",", "possibly", "by", "a", "decrease", "in", "mucosal", "blood", "flow", "."], "h": {"id": "C0030071", "name": "C0030071#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [12, 13]}}
{"token": ["The", "effect", "of", "C0123163#ent", "<e1>", ",", "an", "agent", "improving", "cerebral", "metabolism", "on", "C3536742#ent", "<e2>", "secretion", "was", "examined", "using", "primary", "cultures", "bovine", "adrenal", "chromaffin", "cells"], "h": {"id": "C0123163", "name": "C0123163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536742", "name": "C3536742#ent", "pos": [12, 13]}}
{"token": ["C0059565#ent", "<e1>", ",", "working", "via", "Rap", ",", "acted", "synergistically", "with", "cAMP-dependent", "protein", "kinase", "C0033640#ent", "<e2>", "PKA", "]", ")", "to", "promote", "adipogenesis", "."], "h": {"id": "C0059565", "name": "C0059565#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [13, 14]}}
{"token": ["Switching", "between", "clarithromycin", "and", "C0025872#ent", "<e1>", "should", "be", "considered", "if", "repeated", "courses", "of", "C1422211#ent", "<e2>", "triple", "therapy", "are", "used", "as", "second-line", "therapy", "the", "absence", "of", "antimicrobial", "sensitivity", "testing"], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422211", "name": "C1422211#ent", "pos": [13, 14]}}
{"token": ["The", "apparent", "molecular", "weight", "C1848201#ent", "<e1>", "was", "37,000", "Da", ",", "and", "the", "holoprotein", "consisted", "of", "C0599220#ent", "<e2>", "with", "a", "molecular", "weight", "approximately", "17,000", "Da", "."], "h": {"id": "C1848201", "name": "C1848201#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [15, 16]}}
{"token": ["We", "found", "that", "while", "both", "C2-ceramide", "and", "C2697656#ent", "<e1>", "activated", "c-Jun", "N-terminal", "kinase", "JNK", ")", ",", "only", "C2697656#ent", "<e1>", "also", "activated", "C0600388#ent", "<e1>", "ERKs", ")", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [21, 22]}}
{"token": ["This", "enables", "us", "to", "create", "a", "null", "allele", "specific", "cell", "types", "at", "specific", "time", "points", "crossing", "C1414649#ent", "<e1>", "CKO", "mice", "with", "tissue", "specific", "or", "inducible", "C0073020#ent", "<e2>", "expressing", "mice", "."], "h": {"id": "C1414649", "name": "C1414649#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0073020", "name": "C0073020#ent", "pos": [25, 26]}}
{"token": ["A", "nonulcerogenic", "oral", "dose", "(", "0.15", "mmol/kg", ")", "of", "C0045683#ent", "<e1>", "did", "reduce", "ASA", "ulcers", "L.I.", ":", "24.5", "for", "C3853627#ent", "<e2>", "alone", "vs.", "14.7", "for", "C3853627#ent", "<e2>", "+", "oral", "C0045683#ent", "<e1>", ")", "."], "h": {"id": "C3853627", "name": "C3853627#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0045683", "name": "C0045683#ent", "pos": [9, 10]}}
{"token": ["OGA", "increased", "strongly", "the", "expression", "of", "the", "defence-related", "genes", "C0007965#ent", "<e1>", ",", "GST", ",", "PAL", "and", "C1366763#ent", "<e2>", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1366763", "name": "C1366763#ent", "pos": [16, 17]}}
{"token": ["Probing", "the", "mechanism", "of", "this", "activation", "revealed", "an", "essential", "role", "for", "phosphatidylinositol", "3-kinase", "PI", "3-kinase", "and", "the", "involvement", "of", "a", "C0043167#ent", "<e1>", "G-protein", ",", "a", "Src", "family", "protein", "tyrosine", "kinase", "and", "C0006776#ent", "<e2>"], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0006776", "name": "C0006776#ent", "pos": [31, 32]}}
{"token": ["Although", "the", "functions", "of", "C1705005#ent", "<e1>", "and", "of", "its", "mouse", "homolog", "C1705005#ent", "<e1>", "or", "mTIF2", ")", "have", "been", "clearly", "established", "in", "vitro", "their", "physiological", "role", "remains", "elusive", "."], "h": {"id": "C1705005", "name": "C1705005#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705005", "name": "C1705005#ent", "pos": [4, 5]}}
{"token": ["5", "%", "is", "an", "alternative", "in", "the", "treatment", "of", "C0263361#ent", "<e1>", "the", "face", "region", "shown", "by", "bilateral", "comparison", "studies", "with", "C0016299#ent", "<e2>", "%", "(", "Flucinar", "cream", ")", "."], "h": {"id": "C0263361", "name": "C0263361#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0016299", "name": "C0016299#ent", "pos": [20, 21]}}
{"token": ["Although", "the", "LMNA", "gene", "defect", "for", "this", "\"", "C0231341#ent", "<e1>", "has", "been", "identified", ",", "biological", "mechanisms", "underlying", "the", "accelerated", "C0004153#ent", "<e2>", "are", "unknown", "."], "h": {"id": "C0231341", "name": "C0231341#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [19, 20]}}
{"token": ["C0000970#ent", "<e1>", "might", "be", "protective", "by", "stimulating", "the", "biosynthesis", "of", "C0356622#ent", "<e2>", "in", "the", "stomach", "wall"], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0356622", "name": "C0356622#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "we", "found", "that", "PKCdelta", "but", "not", "classical", "C1826724#ent", "<e1>", ",", "specifically", "phosphorylates", "C1333336#ent", "<e2>", "at", "serine", "89", "in", "vitro", "in", "vivo"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333336", "name": "C1333336#ent", "pos": [16, 17]}}
{"token": ["The", "MLK", "family", "of", "mitogen", "activated", "C0031727#ent", "<e1>", "MAPKKK", ")", "has", "been", "shown", "to", "activate", "C1434650#ent", "<e2>", "JNK/SAPK1", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1434650", "name": "C1434650#ent", "pos": [15, 16]}}
{"token": ["Comparative", "efficacy/tolerability", "data", "with", "long-acting", "formulations", "of", "oxybutynin", "and", "C0724710#ent", "<e1>", "as", "well", "as", "other", "C3540711#ent", "<e2>", "such", "as", "solifenacin", "and", "darifenacin", "are", "not", "available", "."], "h": {"id": "C0724710", "name": "C0724710#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540711", "name": "C3540711#ent", "pos": [15, 16]}}
{"token": ["A", "28-year-old", "Nigerian", "female", "who", "was", "considered", "as", "a", "possible", "case", "of", "C0950122#ent", "<e1>", "presented", "to", "us", "in", "July", "2002", "with", "C0232939#ent", "<e2>", "congenital", "bilateral", "absence", "of", "middle", "toes", "elevated", "blood", "pressure", "and", "the", "uremic", "syndrome"], "h": {"id": "C0950122", "name": "C0950122#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0232939", "name": "C0232939#ent", "pos": [21, 22]}}
{"token": ["In", "C0015967#ent", "<e1>", "rabbits", ",", "the", "plasma", "concentration", "of", "C0004057#ent", "<e2>", "(", "500", "mg/kg", ",", "p.o", ".", ")"], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [9, 10]}}
{"token": ["The", "C0072456#ent", "<e1>", "pp62c-Yes", ")", "encodes", "a", "non-receptor-type", "protein", "tyrosine", "kinase", "NRPTK", ")", "of", "the", "C0282625#ent", "<e2>"], "h": {"id": "C0072456", "name": "C0072456#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [15, 16]}}
{"token": ["Escherichia", "coli", "glutaminyl-tRNA", "synthetase", "C0061493#ent", "<e1>", ")", "(", "EC", "6.1.1.18", ")", "is", "a", "monomeric", "polypeptide", "553", "C3539946#ent", "<e2>"], "h": {"id": "C0061493", "name": "C0061493#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [16, 17]}}
{"token": ["While", "spironolactone", "was", "ineffective", ",", "triamterene", "(", "C0040869#ent", "<e1>", ")", "treatment", "corrected", "the", "hypertension", "and", "hypokalemia", "and", "restored", "C3274822#ent", "<e2>", "to", "normal", "provided", "that", "sodium", "intake", "not", "excessive", "."], "h": {"id": "C0040869", "name": "C0040869#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [18, 19]}}
{"token": ["Hence", "T", "cell", "activation", "can", "be", "critically", "regulated", "by", "the", "Ras", "effector", "pathway", "from", "C1425569#ent", "<e1>", "that", "can", "be", "mimicked", "by", "C1424797#ent", "<e2>"], "h": {"id": "C1425569", "name": "C1425569#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1424797", "name": "C1424797#ent", "pos": [21, 22]}}
{"token": ["The", "identification", "of", "the", "yeast", "genes", "SAM2", "and", "C1335808#ent", "<e1>", ",", "which", "encode", "AdoMet", "synthase", "as", "C1333213#ent", "<e2>", "suppressors", "suggests", "that", "Abd1p", "function", "can", "be", "modulated", "by", "changes", "in", "the", "concentration", "of", "its", "substrate", "AdoMet"], "h": {"id": "C1335808", "name": "C1335808#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333213", "name": "C1333213#ent", "pos": [16, 17]}}
{"token": ["The", "Class", "IV", "agent", "C0042523#ent", "<e1>", ",", "which", "is", "a", "calcium", "channel", "blocker", "has", "potent", "myocardial", "C0003289#ent", "<e2>", "actions", "and", "causes", "peripheral", "vasodilatation"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [16, 17]}}
{"token": ["Of", "77", "patients", "registered", "in", "1969", ",", "64", "had", "haemophilia", "A", "C3494187#ent", "<e1>", "and", "13", "had", "C0019069#ent", "<e2>", "factor", "IX", "deficiency", "."], "h": {"id": "C3494187", "name": "C3494187#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "with", "compensated", "C0018801#ent", "<e1>", "treatment", "with", "digitalis", "and", "diuretics", ",", "C0087093#ent", "<e2>", "treatment", "does", "not", "precipitate", "heart", "failure", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0087093", "name": "C0087093#ent", "pos": [12, 13]}}
{"token": ["Altogether", ",", "microwave", "boiling", "the", "tissue", "sections", "C3256468#ent", "<e1>", "improved", "the", "immunoreactivity", "for", "cytokeratin", "18", "oestrogen", "receptor", "Ki-67", "protein", "C1366837#ent", "<e2>", ",", "p53", "protein", "retinoblastoma", "gene", "protein", "c-erbB-2", "protein"], "h": {"id": "C3256468", "name": "C3256468#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [19, 20]}}
{"token": ["According", "to", "study", "results", ",", "C0027375#ent", "<e1>", "efficacious", "and", "free", "from", "side", "effects", "20", "C0013595#ent", "<e2>", "patients", "."], "h": {"id": "C0027375", "name": "C0027375#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "path", "of", "viral", "transactivation", "transcription", "by", "nuclear", "factor-kappa", "B", "C1417708#ent", "<e1>", ")", "in", "the", "pathogenesis", "of", "C0403397#ent", "<e2>", "SRSNS", ")", "triggered", "by", "respiratory", "tract", "viruses"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0403397", "name": "C0403397#ent", "pos": [19, 20]}}
{"token": ["C0027556#ent", "<e1>", "appeared", "mildly", "dysphoric", ",", "rather", "than", "C0304402#ent", "<e2>", ",", "in", "subjective", "effects"], "h": {"id": "C0027556", "name": "C0027556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [8, 9]}}
{"token": ["C1333928#ent", "<e1>", "phosphorylation", "was", "induced", "by", "butyrate", ",", "propionate", ",", "and", "trichostatin", "A.", "changes", "in", "C1333928#ent", "<e1>", "phosphorylation", "coincide", "with", "the", "activation", "of", "the", "C0257535#ent", "<e1>", "MAPKAPK", "2"], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [24, 25]}}
{"token": ["Eleven", "of", "the", "C0020476#ent", "<e1>", "patients", "were", "treated", "with", "combination", "of", "the", "cholesterol-lowering", "drugs", "C0033215#ent", "<e2>", "and", "colestipol", "."], "h": {"id": "C0020476", "name": "C0020476#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0033215", "name": "C0033215#ent", "pos": [14, 15]}}
{"token": ["After", "C0038366#ent", "<e1>", "and", "amoebic", "C0275524#ent", "<e2>", "rabbits", "showed", "severe", "cornean", "lesions", ",", "the", "viral", "aspect", "cornea", "received", "a", "specific", "treatment", "."], "h": {"id": "C0038366", "name": "C0038366#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [5, 6]}}
{"token": ["These", "observations", "support", "the", "view", "that", "C1964473#ent", "<e1>", "of", "reovirus", "in", "lysosomes", ",", "when", "the", "lytic", "C3541394#ent", "<e2>", "uncoat", "its", "genome", ",", "is", "an", "obligatory", "step", "in", "the", "sequence", "of", "infection", "."], "h": {"id": "C1964473", "name": "C1964473#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [16, 17]}}
{"token": ["In", "January", "1996", ",", "C0011860#ent", "<e1>", "asked", "the", "C1540289#ent", "<e2>", "for", "their", "assistance", "in", "commissioning", "a", "programme", "of", "research", "to", "investigate", "Gulf", "veterans", "'", "health", "concerns", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1540289", "name": "C1540289#ent", "pos": [8, 9]}}
{"token": ["Antiserum", "raised", "against", "collagenase", "from", "C0009053#ent", "<e1>", "found", "to", "cross-react", "with", "cell-associated", "proteins", "by", "C4083008#ent", "<e2>", "and", "to", "inhibit", "C4083008#ent", "<e2>", "FALGPA", "hydrolysis", "."], "h": {"id": "C0009053", "name": "C0009053#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4083008", "name": "C4083008#ent", "pos": [14, 15]}}
{"token": ["The", "unique", "amino-terminal", "domain", "C1427927#ent", "<e1>", "interacts", "with", "the", "FG", "repeat", "domain", "of", "C1417892#ent", "<e2>", ",", "indicating", "that", "C1427927#ent", "<e1>", "associates", "with", "the", "nucleoplasmic", "basket", "the", "NPC", "."], "h": {"id": "C1427927", "name": "C1427927#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417892", "name": "C1417892#ent", "pos": [13, 14]}}
{"token": ["C1417245#ent", "<e1>", "activates", "benzo[a]pyrene", "as", "well", "as", "C0772162#ent", "<e2>", "tobacco", "smoke", "generates", "carcinogen-free", "radicals", "."], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0772162", "name": "C0772162#ent", "pos": [7, 8]}}
{"token": ["Magnetic", "resonance", "spectroscopy", "thus", "be", "of", "help", "in", "differentiating", "C0023264#ent", "<e1>", "a", "range", "of", "other", "mitochondrial", "diseases", "such", "as", "C0029089#ent", "<e2>", "and", "Kearns-Sayre", "syndrome", "showing", "lack", "of", "lactate", "in", "brain", "tissues", "normal", "on", "MRI", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0029089", "name": "C0029089#ent", "pos": [19, 20]}}
{"token": ["C0037763#ent", "<e1>", "is", "\"", "panenepidemic", "\"", "and", "unclassified", "examples", "of", "C0013423#ent", "<e2>", "Dyskinesia", "really", "are", "as", "common", "as", "debt", "and", "taxes", "."], "h": {"id": "C0037763", "name": "C0037763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013423", "name": "C0013423#ent", "pos": [10, 11]}}
{"token": ["C1417215#ent", "<e1>", "inducer", "protein", "EMMPRIN", ")", "and", "MMP", "activator", "membrane-type", "MMP", "C1704883#ent", "<e2>", ")", ",", "as", "well", "as", "MMP-1", ",", "-2", ",", "and", "-9", ",", "were", "quantified", "by", "immunoblotting", "and", "densitometry", "(", "pixels", ")", "."], "h": {"id": "C1417215", "name": "C1417215#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704883", "name": "C1704883#ent", "pos": [11, 12]}}
{"token": ["Addition", "of", "PMN-conditioned", "medium", "to", "C1704883#ent", "<e1>", "expressing", "cells", "resulted", "in", "increased", "proMMP-2", "activation", "and", "in", "vitro", "invasion", "of", "extracellular", "matrix", "C1417215#ent", "<e2>", ")", ",", "but", "had", "no", "effect", "cells", "that", "express", "no", "C1704883#ent", "<e1>", "."], "h": {"id": "C1417215", "name": "C1417215#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1704883", "name": "C1704883#ent", "pos": [5, 6]}}
{"token": ["C0126177#ent", "<e1>", "LE", ")", "is", "a", "C3536709#ent", "<e2>", "designed", "using", "the", "\"", "soft", "drug", "concept", "of", "Bodor", "."], "h": {"id": "C0126177", "name": "C0126177#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [6, 7]}}
{"token": ["The", "study", "showed", "that", "C0936073#ent", "<e1>", "clinically", "related", "concentrations", "could", "inhibit", "the", "release", "of", "C0017789#ent", "<e2>", ",", "but", "had", "no", "effect", "the", "release", "of", "GABA", "from", "rats", "prefrontal", "cortical", "synaptosomes", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [14, 15]}}
{"token": ["Other", "serine", "proteases", "C1416800#ent", "<e1>", "and", "MASP-3", ")", "are", "also", "associated", "with", "C0065661#ent", "<e2>", "or", "ficolins", ";", "however", ",", "their", "functions", "are", "still", "controversial", "."], "h": {"id": "C1416800", "name": "C1416800#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0065661", "name": "C0065661#ent", "pos": [12, 13]}}
{"token": ["Five", "patients", "who", "developed", "C0023530#ent", "<e1>", "following", "intravenous", "administration", "high", "dose", "oxacillin", "for", "serious", "C1318973#ent", "<e2>", "described", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1318973", "name": "C1318973#ent", "pos": [14, 15]}}
{"token": ["Tapasin", "is", "absent", "from", "the", "mutant", "cell", "line", ",", "in", "which", "class", "C1332816#ent", "<e1>", "association", "and", "C0030956#ent", "<e2>", "loading", "is", "defective", "."], "h": {"id": "C1332816", "name": "C1332816#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [16, 17]}}
{"token": ["It", "is", "concluded", "that", "C1417699#ent", "<e1>", "CK", "is", "a", "C0084209#ent", "<e2>", "the", "sequence", "X-Ser/Thr-Pro-X", "or", "Ser/Thr-Pro-X."], "h": {"id": "C1417699", "name": "C1417699#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0084209", "name": "C0084209#ent", "pos": [9, 10]}}
{"token": ["Using", "L1210", "tumor", "as", "a", "model", "for", "systemic", "leukemia", "C0935796#ent", "<e1>", "as", "effective", "as", "free", "C0014582#ent", "<e2>", "at", "equal", "doses", ",", "however", "liposomal-adriamycin", "was", "more", "effective", "at", "MTD", "."], "h": {"id": "C0935796", "name": "C0935796#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [15, 16]}}
{"token": ["Clomethiazole", "(", "C0006795#ent", "<e1>", ")", "was", "used", "as", "a", "model", "C1254351#ent", "<e2>", "to", "be", "incorporated", "into", "an", "emulsion", "vehicle"], "h": {"id": "C0006795", "name": "C0006795#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}}
{"token": ["The", "authors", "describe", "a", "case", "of", "C0686347#ent", "<e1>", "presenting", "with", "C0426575#ent", "<e2>"], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0426575", "name": "C0426575#ent", "pos": [10, 11]}}
{"token": ["Sucrose", "synthase", "SS", ";", "C1259497#ent", "<e1>", "was", "radiolabeled", "in", "situ", "incubating", "detached", "C0947608#ent", "<e2>", "nodules", "with", "32Pi", "."], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0947608", "name": "C0947608#ent", "pos": [12, 13]}}
{"token": ["Full", "activation", "of", "C0084340#ent", "<e1>", "required", "Ect2", "as", "well", "as", "C1418615#ent", "<e2>", "indicating", "that", "these", "two", "proteins", "act", "in", "conjunction", "to", "regulate", "C0084340#ent", "<e1>", "during", "cytokinesis", "."], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418615", "name": "C1418615#ent", "pos": [10, 11]}}
{"token": ["There", "were", "many", "reports", "of", "C0393819#ent", "<e1>", "with", "cranial", "nerve", "involvements", ",", "but", "recurrent", "C0155338#ent", "<e2>", "in", "C0393819#ent", "<e1>", "is", "rare", "."], "h": {"id": "C0393819", "name": "C0393819#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0155338", "name": "C0155338#ent", "pos": [14, 15]}}
{"token": ["We", "have", "studied", "fibroblast", "cultures", "from", "three", "patients", "with", "C0220710#ent", "<e1>", "sequencing", "the", "entire", "coding", "region", "C0220710#ent", "<e1>", "mRNA", "."], "h": {"id": "C0220710", "name": "C0220710#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0220710", "name": "C0220710#ent", "pos": [9, 10]}}
{"token": ["Phospholipase", "A2", "C0031667#ent", "<e1>", ")", "induces", "hyper-sensitivity", "to", "C0003385#ent", "<e2>", "airway", "smooth", "muscle", "in", "vitro"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003385", "name": "C0003385#ent", "pos": [8, 9]}}
{"token": ["Dyslipidemia", "alone", "does", "not", "fully", "explain", "the", "increase", "in", "cardiovascular", "events", "patients", "receiving", "C0033607#ent", "<e1>", "treatment", "for", "human", "C0001175#ent", "<e2>"], "h": {"id": "C0033607", "name": "C0033607#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001175", "name": "C0001175#ent", "pos": [18, 19]}}
{"token": ["The", "urinary", "excretion", "gamma-carboxyglutamic", "acid", "Gla", ")", ",", "the", "C2917660#ent", "<e1>", "in", "the", "vitamin", "K-dependent", "calcium", "binding", "prothrombin", "and", "clotting", "factors", ",", "C1413052#ent", "<e2>", ",", "and", "X", ",", "was", "studied", "in", "warfarin-anticoagulated", "patients", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413052", "name": "C1413052#ent", "pos": [22, 23]}}
{"token": ["The", "potential", "involvement", "of", "C0030940#ent", "<e1>", "this", "action", "of", "C0040615#ent", "<e2>", "were", "also", "examined", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [9, 10]}}
{"token": ["Somatic", "mutations", "the", "tyrosine", "kinase", "TK", ")", "domain", "of", "the", "epidermal", "growth", "factor", "receptor", "EGFR", ")", "C0017337#ent", "<e1>", "are", "reportedly", "associated", "with", "sensitivity", "of", "lung", "cancers", "gefitinib", "(", "C0919281#ent", "<e2>", ")", ",", "kinase", "inhibitor"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0919281", "name": "C0919281#ent", "pos": [28, 29]}}
{"token": ["Phospho-STAT5", ",", "total", "C1705050#ent", "<e1>", ",", "and", "total", "C0812228#ent", "<e2>", "levels", "were", "also", "reduced", "by", "17-AAG", "treatment", "."], "h": {"id": "C1705050", "name": "C1705050#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [8, 9]}}
{"token": ["Gastroesophageal", "reflux", "disease", "result", "in", "such", "supraesophageal", "complications", "as", "hoarseness", ",", "sore", "throat", "C0010200#ent", "<e1>", ",", "bronchitis", ",", "asthma", ",", "C0747651#ent", "<e2>", "intermittent", "choking", ",", "chest", "pain", "and", "ear", "pain"], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0747651", "name": "C0747651#ent", "pos": [20, 21]}}
{"token": ["Although", "these", "two", "terpene", "synthases", "very", "similar", "catalytic", "properties", "and", "synthesize", "C0064997#ent", "<e1>", "and", "nerolidol", "as", "specific", "products", "from", "C0343055#ent", "<e2>", "and", "FPP", ",", "respectively", ",", "they", "are", "compartmentally", "segregated", "."], "h": {"id": "C0064997", "name": "C0064997#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0343055", "name": "C0343055#ent", "pos": [19, 20]}}
{"token": ["Alterations", "in", "the", "ocular", "vasculature", "associated", "with", "C0035309#ent", "<e1>", "as", "retinopathy", "of", "prematurity", "and", "C0011884#ent", "<e2>"], "h": {"id": "C0035309", "name": "C0035309#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [14, 15]}}
{"token": ["Laser", "photocoagulation", "been", "employed", "extensively", "by", "ophthalmologists", "to", "treat", "C0035309#ent", "<e1>", "disorders", "such", "as", "C0011884#ent", "<e2>", "macular", "degeneration", "and", "retinal", "tears"], "h": {"id": "C0035309", "name": "C0035309#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0011884", "name": "C0011884#ent", "pos": [14, 15]}}
{"token": ["Synthesis", ",", "processing", "and", "sorting", "of", "C0072034#ent", "<e1>", "proCD", ")", ",", "the", "precursor", "of", "a", "C0108471#ent", "<e2>", "in", "tumor-cell", "proliferation", "and", "invasion", ",", "were", "compared", "in", "various", "human", "tumor", "cell", "lines"], "h": {"id": "C0072034", "name": "C0072034#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [15, 16]}}
{"token": ["Under", "in", "vitro", ",", "Foxl2", "binds", "to", "the", "sequence", "ACAAATA", "in", "the", "promoter", "region", "the", "C1366496#ent", "<e1>", "through", "its", "forkhead", "domain", "activates", "the", "transcription", "of", "C3254086#ent", "<e2>", "with", "its", "C", "terminus", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [15, 16]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3254086", "name": "C3254086#ent", "pos": [25, 26]}}
{"token": ["Despite", "the", "administration", "of", "postoperative", "adjuvant", "chemotherapy", "of", "cisplatin/adriamycin/5-fluorouracil", "in", "combination", "with", "oral", "etoposide", "and", "immunotherapy", "using", "C0053355#ent", "<e1>", ",", "paraplegia", "suddenly", "developed", "caused", "by", "the", "metastasis", "of", "C1422342#ent", "<e2>", "to", "the", "epidural", "space"], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1422342", "name": "C1422342#ent", "pos": [28, 29]}}
{"token": ["Typical", "causes", "of", "bleeding", "include", "vascular", "infiltration", "malignant", "cells", "C0221030#ent", "<e1>", "thrombocytopenia", "secondary", "to", "bone", "marrow", "infiltration", "treatment", ",", "uremia", ",", "and", "C0005779#ent", "<e2>", "secondary", "to", "liver", "dysfunction", "sepsis", "."], "h": {"id": "C0221030", "name": "C0221030#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [22, 23]}}
{"token": ["The", "rapid", "C1337111#ent", "<e1>", "ACTH", ")", "stimulation", "test", "useful", "for", "identifying", "C0405580#ent", "<e2>"], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0405580", "name": "C0405580#ent", "pos": [11, 12]}}
{"token": ["In", "vitro", "assays", "using", "peptides", "based", "on", "the", "sequence", "in", "C3539947#ent", "<e1>", "-", "2551", "of", "mTOR", "found", "that", "PKB", "and", "C1418898#ent", "<e2>", "are", "capable", "of", "phosphorylating", "sites", "this", "region", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418898", "name": "C1418898#ent", "pos": [20, 21]}}
{"token": ["A", "mildly", "retarded", "infant", "with", "failure", "to", "thrive", "developed", "C0020615#ent", "<e1>", ",", "focal", "seizures", "respiratory", "failure", "hemiparesis", "during", "a", "C0009952#ent", "<e2>", "episode", "at", "the", "age", "of", "16", "months", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [19, 20]}}
{"token": ["The", "various", "endo-", "and", "C0117059#ent", "<e1>", "of", "Fasciola", "hepatica", "the", "causative", "agent", "C0009021#ent", "<e2>", "are", "reviewed", ",", "and", "recent", "reports", "of", "how", "these", "enzymes", "have", "been", "successfully", "employed", "in", "cocktail", "vaccines", "are", "discussed", "."], "h": {"id": "C0117059", "name": "C0117059#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0009021", "name": "C0009021#ent", "pos": [12, 13]}}
{"token": ["Proteasomal", "activity", "isolated", "monocytes", "from", "subjects", "with", "different", "variants", "of", "large", "multifunctional", "proteases", "genes", "(", "Arg60", "-", "->His", "C0002085#ent", "<e1>", "polymorphism", ")", "and", "C1419018#ent", "<e2>", "(", "Lys145", "-", "->Gln", "C0002085#ent", "<e1>", "polymorphism", ")", "was", "determined", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1419018", "name": "C1419018#ent", "pos": [23, 24]}}
{"token": ["In", "studies", "of", "the", "rates", "of", "thrombotic", "episodes", "patients", "with", "the", "C0311370#ent", "<e1>", "LAC", ")", "and", ",", "or", "ACAs", "associated", "with", "C0014060#ent", "<e2>", "and", "non-", "SLE", "diseases", "is", "considerable", "variation", "."], "h": {"id": "C0311370", "name": "C0311370#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [21, 22]}}
{"token": ["This", "type", "of", "infantile", "C4049202#ent", "<e1>", "to", "be", "a", "C0019247#ent", "<e2>", "autosomal", "recessive", "characteristics", ",", "although", "a", "partially", "penetrant", "X-linked", "or", "autosomal", "dominant", "trait", "can", "not", "be", "excluded", "."], "h": {"id": "C4049202", "name": "C4049202#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [9, 10]}}
{"token": ["Degradation", ",", "however", ",", "was", "hampered", "by", "incubating", "the", "C1456795#ent", "<e1>", "with", "the", "C3537238#ent", "<e2>", "epoxomicin", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3537238", "name": "C3537238#ent", "pos": [13, 14]}}
{"token": ["From", "an", "analysis", "of", "the", "changes", "in", "patterns", "of", "digestion", "by", "C0011519#ent", "<e1>", "deduce", "that", "C1516978#ent", "<e2>", "binds", "best", "to", "regions", "of", "mixed", "nucleotide", "sequence", "especially", "those", "containing", "alternating", "purines", "and", "pyrimidines", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1516978", "name": "C1516978#ent", "pos": [15, 16]}}
{"token": ["After", "accounting", "for", "excitation", "transfer", ",", "the", "torsion", "constants", "of", "the", "linear", "C0011519#ent", "<e1>", "are", "found", "to", "be", "essentially", "independent", "of", "intercalated", "C1516978#ent", "<e2>", "up", "to", "a", "binding", "ratio", "=", "0.10", "dye/bp", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1516978", "name": "C1516978#ent", "pos": [22, 23]}}
{"token": ["C0027235#ent", "<e1>", "seems", "to", "have", "a", "beneficial", "effect", "on", "C0035460#ent", "<e2>", "which", "often", "is", "an", "irritating", "condition", "in", "elderly", "patients", "."], "h": {"id": "C0027235", "name": "C0027235#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0035460", "name": "C0035460#ent", "pos": [9, 10]}}
{"token": ["This", "protein", ",", "C1705772#ent", "<e1>", ",", "displays", "structural", "similarity", "to", "CREB", "and", "to", "C1623430#ent", "<e2>", "and", "c-Fos", ",", "which", "bind", "the", "related", "12-O-tetradecanoylphorbol-13-acetate", "response", "element", "TRE", ")", "."], "h": {"id": "C1705772", "name": "C1705772#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [13, 14]}}
{"token": ["The", "authors", "investigated", "principal", "morphometric", "parameters", "of", "peripheral", "blood", "sputum", "eosinophils", "18", "patients", "with", "moderate", "C0004096#ent", "<e1>", "combined", "treatment", "in", "healthy", "donors", "BA", "patients", "treated", "for", "a", "long", "time", "C0012694#ent", "<e2>", "SC", ")", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [29, 30]}}
{"token": ["The", "Km", "for", "the", "three", "main", "substrates", "were", "1.6", "mm", "for", "1,2-propanediol", ",", "5.5", "mm", "for", "C1880991#ent", "<e1>", "and", "8.3", "mm", "for", "C0017868#ent", "<e2>", "."], "h": {"id": "C1880991", "name": "C1880991#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [22, 23]}}
{"token": ["The", "aim", "of", "this", "study", "is", "to", "evaluate", "the", "efficiency", "of", "low-dose", ",", "C0019139#ent", "<e1>", "enoxaparin", ")", "in", "the", "treatment", "of", "lichen", "planus", "C2239920#ent", "<e2>", ")", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2239920", "name": "C2239920#ent", "pos": [23, 24]}}
{"token": ["The", "drug", "was", "compared", "with", "C0012010#ent", "<e1>", "(", "widely", "accepted", "as", "an", "effective", "C0026838#ent", "<e2>", "and", "a", "placebo", "."], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0026838", "name": "C0026838#ent", "pos": [13, 14]}}
{"token": ["However", ",", "while", "the", "C0243459#ent", "<e1>", "staurosporine", "completely", "prevented", "the", "desensitization", "caused", "by", "C0032143#ent", "<e2>", ",", "it", "had", "only", "a", "limited", "effect", "on", "the", "desensitization", "caused", "by", "TRP42/55", "."], "h": {"id": "C0243459", "name": "C0243459#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [13, 14]}}
{"token": ["LH", "and", "C0016424#ent", "<e1>", "regulate", "the", "hormonal", "production", "the", "C0018050#ent", "<e2>", "as", "well", "as", "gametogenesis", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [9, 10]}}
{"token": ["At", "least", "three", "loci", "(", "EXT1", ",", "C1414488#ent", "<e1>", "and", "EXT3", ")", "thought", "to", "be", "involved", "in", "this", "C0026848#ent", "<e2>"], "h": {"id": "C1414488", "name": "C1414488#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [18, 19]}}
{"token": ["At", "least", "three", "loci", "(", "EXT1", ",", "EXT2", "and", "C1414488#ent", "<e1>", ")", "thought", "to", "be", "involved", "in", "this", "C0026848#ent", "<e2>"], "h": {"id": "C1414488", "name": "C1414488#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [18, 19]}}
{"token": ["This", "domain", "possesses", "C0001473#ent", "<e1>", "and", "helicase", "activity", "defining", "this", "as", "the", "minimal", "C1310463#ent", "<e2>"], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1310463", "name": "C1310463#ent", "pos": [13, 14]}}
{"token": ["C1826646#ent", "<e1>", "also", "attenuated", "the", "DTLET-mediated", "activation", "of", "C0752312#ent", "<e2>", "as", "well", "as", "rapid", "delta-OR", "internalization", ",", "but", "not", "receptor", "down-regulation", "."], "h": {"id": "C1826646", "name": "C1826646#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [8, 9]}}
{"token": ["This", "process", "takes", "more", "time", "in", "C1417005#ent", "<e1>", "than", "in", "C1427199#ent", "<e2>", "."], "h": {"id": "C1417005", "name": "C1417005#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1427199", "name": "C1427199#ent", "pos": [10, 11]}}
{"token": ["C0030781#ent", "<e1>", "likely", "to", "have", "the", "same", "etiologic", "agent", "C0002992#ent", "<e2>"], "h": {"id": "C0030781", "name": "C0030781#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002992", "name": "C0002992#ent", "pos": [9, 10]}}
{"token": ["Methotrexate", "has", "been", "associated", "with", "chronic", "toxicities", "as", "C1623038#ent", "<e1>", "and", "neurological", "impairments", "from", "mild", "learning", "disorders", "a", "fatal", "C0270786#ent", "<e2>", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0270786", "name": "C0270786#ent", "pos": [19, 20]}}
{"token": ["Antioxidants", ",", "desferrioxamine", "(", "C0394006#ent", "<e1>", ")", "and", "o-phenanthroline", "(", "OP", ")", "partially", "inhibited", "the", "C1415619#ent", "<e2>", "mRNA", "elevation", "by", "hyperoxia", "."], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [15, 16]}}
{"token": ["Subcellular", "fractionation", "C0027803#ent", "<e1>", "that", "both", "C1705231#ent", "<e2>", "forms", "were", "transported", "to", "the", "plasma", "membrane"], "h": {"id": "C0027803", "name": "C0027803#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705231", "name": "C1705231#ent", "pos": [6, 7]}}
{"token": ["Skin", "lesions", "patients", "with", "AD", ",", "but", "not", "C0033860#ent", "<e1>", ",", "is", "deficient", "in", "the", "C1413106#ent", "<e2>", "LL-37", ")", "and", "human", "beta-defensin-2", "HBD-2", ")", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413106", "name": "C1413106#ent", "pos": [15, 16]}}
{"token": ["One", "of", "the", "ligand-dependent", "clones", ",", "ARA9", ",", "encodes", "a", "novel", "330-amino", "acid", "protein", "with", "regions", "of", "amino", "acid", "sequence", "to", "the", "C1414618#ent", "<e1>", "to", "be", "associated", "with", "C1334899#ent", "<e2>"], "h": {"id": "C1414618", "name": "C1414618#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [28, 29]}}
{"token": ["We", "find", "that", "C0812271#ent", "<e1>", "directly", "interacts", "with", "C1420532#ent", "<e2>", "and", "that", "the", "proteins", "form", "an", "active", "complex", "methyltransferase", "activity", "in", "vitro"], "h": {"id": "C0812271", "name": "C0812271#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420532", "name": "C1420532#ent", "pos": [8, 9]}}
{"token": ["Blockade", "of", "C1418401#ent", "<e1>", "or", "B7-H1", ",", "but", "not", "C1425745#ent", "<e2>", ",", "led", "to", "accelerated", "corneal", "allograft", "rejection"], "h": {"id": "C1418401", "name": "C1418401#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1425745", "name": "C1425745#ent", "pos": [9, 10]}}
{"token": ["DNA", "index", "labeling", "index", "C1420713#ent", "<e1>", ")", ",", "duration", "of", "S-phase", "Ts", ")", "and", "potential", "doubling", "time", "C0812295#ent", "<e2>", ")", "were", "calculated", "using", "standard", "procedures"], "h": {"id": "C1420713", "name": "C1420713#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812295", "name": "C0812295#ent", "pos": [17, 18]}}
{"token": ["C3541418#ent", "<e1>", "stimulates", "the", "activity", "of", "a", "master", "regulator", "mitochondrial", "biogenesis", "stress", "response", "C1418779#ent", "<e2>", "PGC-1alpha", ")", ",", "in", "the", "transcription", "of", "the", "MnSOD", "."], "h": {"id": "C3541418", "name": "C3541418#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [13, 14]}}
{"token": ["Fibrinolytic", "parameters", "and", "C1336938#ent", "<e1>", "VWF", ")", "antigen", "were", "measured", "in", "22", "patients", "with", "C0156221#ent", "<e2>", "(", "GN", ")", "who", "underwent", "renal", "biopsy", "desmopressin", "(", "DDAVP", ")", "infusion", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [14, 15]}}
{"token": ["C0812443#ent", "<e1>", "can", "activate", "beta(1)-integrins", "on", "progenitor", "cells", "increase", "binding", "to", "C1706331#ent", "<e2>", "."], "h": {"id": "C0812443", "name": "C0812443#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [11, 12]}}
{"token": ["Plasma", "post-DST", "C1704793#ent", "<e1>", "and", "cortisol", "concentrations", "significantly", "increased", "by", "the", "acute", "administration", "C0006462#ent", "<e2>", "(", "30", "mg", "PO", ")", "compared", "to", "placebo", "."], "h": {"id": "C1704793", "name": "C1704793#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006462", "name": "C0006462#ent", "pos": [13, 14]}}
{"token": ["To", "assess", "the", "role", "of", "C1416931#ent", "<e1>", "LTbetaR", ")", "in", "C0011849#ent", "<e2>", "pathogenesis", ",", "we", "expressed", "an", "LTbetaR-Fc", "fusion", "protein", "in", "nonobese", "diabetic", "NOD", ")", "mice", "."], "h": {"id": "C1416931", "name": "C1416931#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}}
{"token": ["During", "the", "391st", "to", "613th", "postoperative", "day", "she", "experienced", "recurrent", "cerebral", "infarctions", "but", "clinical", "examinations", "C0012634#ent", "<e1>", "of", "producing", "C0007780#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007780", "name": "C0007780#ent", "pos": [19, 20]}}
{"token": ["Intermittent", "C0010583#ent", "<e1>", "seems", "effective", "in", "some", "cases", "of", "C0398650#ent", "<e2>", "is", "safe", ",", "at", "least", "in", "the", "short", "term"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0398650", "name": "C0398650#ent", "pos": [9, 10]}}
{"token": ["Pulsed-field", "gel", "electrophoresis", "multilocus", "sequence", "typing", "analysis", "that", "24", "(", "39", "%", ")", "of", "the", "serotype", "23A", "C1875400#ent", "<e1>", "shared", "either", "genetic", "identity", "high", "genetic", "relatedness", "with", "C4283796#ent", "<e2>", "clone", "Colombia(23F)-26", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [27, 28]}}
{"token": ["Ifosfamide", "mustard", "an", "active", "metabolite", "C0020823#ent", "<e1>", ",", "was", "equally", "cytotoxic", "and", "showed", "similar", "mutagenic", "effects", "C1861380#ent", "<e2>", "and", "parental", "V79", "cells", "."], "h": {"id": "C0020823", "name": "C0020823#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1861380", "name": "C1861380#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "suggest", "that", "EGF", "and", "C1708015#ent", "<e1>", ",", "combined", "with", "C2983552#ent", "<e2>", ",", "represent", "the", "universally", "applicable", "regimen", "for", "the", "expansion", "of", "the", "neural", "progenitor", "following", "ischemia", "."], "h": {"id": "C1708015", "name": "C1708015#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2983552", "name": "C2983552#ent", "pos": [11, 12]}}
{"token": ["Apert", "and", "C1333542#ent", "<e1>", "well", "known", "C1865639#ent", "<e2>", "."], "h": {"id": "C1333542", "name": "C1333542#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1865639", "name": "C1865639#ent", "pos": [6, 7]}}
{"token": ["It", "also", "reduces", "joint", "swelling", "damage", "in", "an", "animal", "model", "C0038013#ent", "<e1>", "possibly", "by", "reducing", "C1522428#ent", "<e2>", "mediated", "synthesis", "of", "proteases", "by", "the", "synovial", "fibroblasts", "chondrocytes", "of", "the", "joint", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [15, 16]}}
{"token": ["While", "ctk1", "mutant", "cells", "contain", "phosphorylated", "forms", "of", "the", "C1335231#ent", "<e1>", "these", "forms", "differ", "from", "those", "found", "in", "wild", "type", "cells", "implicating", "C4283918#ent", "<e2>", "as", "a", "component", "of", "the", "physiologically", "significant", "CTD", "phosphorylating", "."], "h": {"id": "C1335231", "name": "C1335231#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4283918", "name": "C4283918#ent", "pos": [22, 23]}}
{"token": ["Ribonuclease", "III", "RNase", "III", "represents", "a", "highly", "conserved", "family", "of", "double-stranded", "(ds)", "C1309483#ent", "<e1>", "exemplified", "by", "bacterial", "RNase", "III", "eukaryotic", "Rnt1p", ",", "Drosha", "and", "C1333218#ent", "<e2>", "."], "h": {"id": "C1309483", "name": "C1309483#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333218", "name": "C1333218#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "the", "effects", "of", "C0032950#ent", "<e1>", "on", "cell", "membrane", "bleb", "formation", ",", "calpain", "mu", "activation", "and", "C1420760#ent", "<e2>", "degradation", "during", "hepatic", "ischemia-reperfusion", "injury", "rats", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420760", "name": "C1420760#ent", "pos": [17, 18]}}
{"token": ["TNF-alpha", "secretion", "into", "the", "ascitic", "fluid", "fasted", "rats", "was", "markedly", "suppressed", ",", "and", "fasting", "donor", "animals", "induced", "C1268903#ent", "<e1>", "such", "as", "GRP78", ",", "in", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C1268903", "name": "C1268903#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [25, 26]}}
{"token": ["Collectively", ",", "our", "results", "suggest", "that", "RAS", "C1417123#ent", "<e1>", "induces", "RECK", "gene", "silencing", "DNMT3b-mediated", "promoter", "methylation", ",", "and", "C1414121#ent", "<e2>", "inhibitors", "may", "be", "useful", "for", "the", "treatment", "of", "RAS-induced", "metastasis", "."], "h": {"id": "C1417123", "name": "C1417123#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414121", "name": "C1414121#ent", "pos": [18, 19]}}
{"token": ["About", "10", "-", "15", "%", "of", "the", "patients", "with", "acute", "symptoms", "a", "C0008679#ent", "<e1>", "scleroderma-like", "skin", "manifestations", ",", "C0152025#ent", "<e2>", "and", "myositis", "."], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0152025", "name": "C0152025#ent", "pos": [18, 19]}}
{"token": ["Diabetics", "develop", "numerous", "C0008679#ent", "<e1>", "among", "them", "C0152025#ent", "<e2>"], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0152025", "name": "C0152025#ent", "pos": [7, 8]}}
{"token": ["Overexpression", "of", "these", "dominant", "negative", "mutants", "triggers", "upregulation", "of", "the", "protein", "levels", "the", "C1511576#ent", "<e1>", "p27", ",", "a", "major", "negative", "C1539026#ent", "<e2>"], "h": {"id": "C1511576", "name": "C1511576#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1539026", "name": "C1539026#ent", "pos": [20, 21]}}
{"token": ["The", "tumor", "suppressor", "gene", "p16INK4A", "is", "a", "C1511576#ent", "<e1>", "CDKI", ")", "and", "an", "important", "C1539026#ent", "<e2>"], "h": {"id": "C1511576", "name": "C1511576#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539026", "name": "C1539026#ent", "pos": [14, 15]}}
{"token": ["Fourteen", "patients", "suffering", "from", "C0393786#ent", "<e1>", "refractory", "to", "medication", ")", "were", "treated", "by", "injection", "of", "C0017868#ent", "<e2>", "into", "the", "trigeminal", "ganglion"], "h": {"id": "C0393786", "name": "C0393786#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [15, 16]}}
{"token": ["Acute", "inflammatory", "demyelinating", "polyneuropathy", "Guillain-Barr\u00e9", "syndrome", "C0018378#ent", "<e1>", ")", "is", "the", "prototype", "of", "these", "C0029132#ent", "<e2>", "."], "h": {"id": "C0018378", "name": "C0018378#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029132", "name": "C0029132#ent", "pos": [14, 15]}}
{"token": ["We", "found", "that", "C1705632#ent", "<e1>", "(", "wild", "type", "WT", ")", "mediated", "H(2)O(2)-induced", "C0029007#ent", "<e2>", "up-regulation", "."], "h": {"id": "C1705632", "name": "C1705632#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029007", "name": "C0029007#ent", "pos": [12, 13]}}
{"token": ["As", "PLD2", "can", "utilize", "the", "physiological", "C0001962#ent", "<e1>", "form", "phosphatidylglycerol", "(", "PG", ")", ",", "we", "hypothesized", "that", "C1412493#ent", "<e2>", "provides", "glycerol", "to", "PLD2", "for", "PG", "synthesis", ",", "which", "then", "modulates", "keratinocyte", "function"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412493", "name": "C1412493#ent", "pos": [17, 18]}}
{"token": ["The", "main", "differential", "diagnoses", "comprise", "retinoblastoma", ",", "retrolental", "fibroplasia", "C0040558#ent", "<e1>", ",", "falciform", "detachment", ",", "C0271091#ent", "<e2>", "sex-linked", "microphthalmia", ",", "sex-linked", "cataract", "and", "congenital", "retinal", "detachment"], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0271091", "name": "C0271091#ent", "pos": [15, 16]}}
{"token": ["Diminishing", "C1415619#ent", "<e1>", "activity", "by", "the", "C1415619#ent", "<e1>", "inhibitor", "C0076694#ent", "<e1>", "SnPPIX", ")", "significantly", "enhanced", "the", "formation", "of", "PPIX", "up", "to", "1.8", "fold", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0076694", "name": "C0076694#ent", "pos": [9, 10]}}
{"token": ["Two", "structurally", "distinct", "inhibitors", "of", "C1417708#ent", "<e1>", "activation", "or", "translocation", "abrogated", "the", "TNFalpha", "effect", "on", "the", "C1412481#ent", "<e2>"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [16, 17]}}
{"token": ["Binding", "sites", "putative", "transcriptional", "factors", "TF", ")", ",", "such", "as", "AP-1", ",", "AP-2", "and", "C1417708#ent", "<e1>", ",", "are", "present", "in", "the", "C1412481#ent", "<e2>", "promoter", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [21, 22]}}
{"token": ["There", "are", "several", "reports", "linking", "C1835677#ent", "<e1>", "and", "connective", "tissue", "disorders", "such", "as", "Ehlers-Danlos", "syndrome", "osteogenesis", "imperfecta", "C1843003#ent", "<e2>", "suggesting", "that", "C1835677#ent", "<e1>", "may", "be", "the", "result", "of", "a", "localized", "dysfunction", "in", "collagen", "metabolism"], "h": {"id": "C1843003", "name": "C1843003#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1835677", "name": "C1835677#ent", "pos": [5, 6]}}
{"token": ["C1414438#ent", "<e1>", "has", "been", "used", "in", "patients", "with", "C0008679#ent", "<e2>", "years", ",", "and", "more", "recently", "it", "has", "been", "used", "to", "treat", "acute", "ischemic", "stroke"], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [8, 9]}}
{"token": ["This", "case", "report", "the", "combination", "of", "C1414438#ent", "<e1>", "and", "IV", "iron", "supplementation", "patients", "with", "anemia", "of", "C0008679#ent", "<e2>", "either", "an", "impaired", "iron", "absorption", "intolerance", "to", "oral", "iron", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "the", "glomerular", "expression", "C1416962#ent", "<e1>", "was", "closely", "correlated", "with", "the", "C0268731#ent", "<e2>", "expression", "of", "Col4", "and", "smooth", "muscle", "alpha", "actin", "alpha-SMA", ")", ",", "while", "albuminuria", "or", "glomerular", "filtration", "rate", "not", "correlated", "with", "mesangial", "matrix", "expansion", "."], "h": {"id": "C1416962", "name": "C1416962#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [12, 13]}}
{"token": ["Of", "52", "consecutive", "patients", "with", "ICA", "dissection", "had", "C0151311#ent", "<e1>", "2", "had", "an", "involvement", "of", "the", "C0152177#ent", "<e2>", "5", "had", "lower", "C0151311#ent", "<e1>"], "h": {"id": "C0151311", "name": "C0151311#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0152177", "name": "C0152177#ent", "pos": [16, 17]}}
{"token": ["Results", "involving", "in", "vitro", "phosphorylation", "of", "purified", "C1415042#ent", "<e1>", "or", "biological", "samples", "brain", "tissue", "cell", "culture", "cerebrospinal", "fluid", "mediated", "by", "C0033640#ent", "<e2>", "on", "cAMP", "indicate", "that", "C1415042#ent", "<e1>", "phosphorylation", "improves", "the", "recognition", "by", "the", "used", "antibody", "."], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [20, 21]}}
{"token": ["The", "head", "domain", "a", "di-arginine/aromatic", "amino", "acid", "motif", "which", "is", "also", "found", "in", "the", "head", "domains", "of", "various", "C1415042#ent", "<e1>", "includes", "a", "potential", "C0033640#ent", "<e2>", "phosphorylation", "site", "."], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [23, 24]}}
{"token": ["Studies", "have", "indicated", "that", "DMXAA", "glucuronidation", "is", "catalysed", "by", "uridine", "diphosphate", "glucuronosyltransferases", "UGT1A9", "and", "C1421346#ent", "<e1>", ")", ",", "and", "6-methylhydroxylation", "by", "cytochrome", "P450", "C1620185#ent", "<e2>", ")", "."], "h": {"id": "C1421346", "name": "C1421346#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [23, 24]}}
{"token": ["The", "reversal", "effect", "C0014582#ent", "<e1>", "resistance", "by", "siRNA", "of", "C1823242#ent", "<e2>", "was", "more", "effective", "than", "that", "of", "MDR3", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823242", "name": "C1823242#ent", "pos": [9, 10]}}
{"token": ["C0014582#ent", "<e1>", "(", "ADM", ")", ",", "an", "anthracycline", "C0304497#ent", "<e2>", "was", "conjugated", "with", "monoclonal", "antibody", "against", "gastric", "cancer", "the", "dextran", "bridge", "method", "."], "h": {"id": "C0014582", "name": "C0014582#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304497", "name": "C0304497#ent", "pos": [8, 9]}}
{"token": ["The", "activities", "of", "C0015110#ent", "<e1>", "aryl", "hydrocarbon", "hydroxylase", "decreased", "when", "expressed", "per", "gram", "of", "C0001214#ent", "<e2>"], "h": {"id": "C0015110", "name": "C0015110#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001214", "name": "C0001214#ent", "pos": [14, 15]}}
{"token": ["BA", "increased", "the", "expression", "of", "MHC", "II", "C2985420#ent", "<e1>", "APCs", "compared", "with", "C1420423#ent", "<e2>", "."], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [12, 13]}}
{"token": ["The", "relative", "unimportance", "of", "the", "salvage", "pathway", "catalysed", "by", "C0020687#ent", "<e1>", "shown", "by", "the", "normal", "responses", "T-lymphocytes", "from", "patients", "with", "the", "C1415701#ent", "<e2>", "antigenic", "and", "mitogenic", "stimulation", "."], "h": {"id": "C0020687", "name": "C0020687#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415701", "name": "C1415701#ent", "pos": [21, 22]}}
{"token": ["Tocilitumab", "therapy", "was", "effective", "in", "this", "C1417196#ent", "<e1>", "patient", ",", "however", "its", "influence", "on", "concurrent", "C0024115#ent", "<e2>", "to", "be", "investigated", "further", "."], "h": {"id": "C1417196", "name": "C1417196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [15, 16]}}
{"token": ["The", "prevalences", "of", "cholecystolithiasis", "increased", "along", "with", "the", "increasing", "C0720099#ent", "<e1>", "and", "severity", "of", "C0341439#ent", "<e2>", "with", "a", "significant", "linear", "trend", "p", "less", "than", "0.001", ")", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0341439", "name": "C0341439#ent", "pos": [14, 15]}}
{"token": ["We", "report", "the", "first", "successfully", "treated", "case", "of", "Cladophialophora", "bantiana", "C1510428#ent", "<e1>", "the", "relatively", "new", "antifungal", "agent", "C0393080#ent", "<e2>", "."], "h": {"id": "C1510428", "name": "C1510428#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0393080", "name": "C0393080#ent", "pos": [17, 18]}}
{"token": ["More", "specific", "are", "the", "positive", "correlations", "between", "RAS", "C0678941#ent", "<e1>", "MYC", "expression", "and", "the", "cellular", "sensitivity", "C0069717#ent", "<e2>", "."], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0069717", "name": "C0069717#ent", "pos": [16, 17]}}
{"token": ["C0107497#ent", "<e1>", "is", "a", "new", "C0003308#ent", "<e2>", "primary", "fungicidal", "activity", "dermatophytes", "such", "as", "Trichophyton", "mentagrophytes", "Microsporum", "canis", "Trichophyton", "rubrum", "cause", "tinea", "infections"], "h": {"id": "C0107497", "name": "C0107497#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [5, 6]}}
{"token": ["We", "hypothesized", "that", "C0387583#ent", "<e1>", "PGHS-2", ")", "was", "one", "of", "the", "unidentified", "C1417679#ent", "<e2>", "induced", "by", "taxol", "."], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Sequence", "analysis", "mutant", "aod-1", "C0002085#ent", "<e1>", "reveals", "mutations", "affecting", "the", "coding", "sequence", "the", "alternative", "C0242417#ent", "<e2>", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242417", "name": "C0242417#ent", "pos": [14, 15]}}
{"token": ["The", "activity", "of", "these", "anthrapyrazole", "analogues", "was", "compared", "with", "that", "of", "two", "clinically", "tested", "C0051960#ent", "<e1>", ",", "losoxantrone", "and", "C1522210#ent", "<e2>", "."], "h": {"id": "C0051960", "name": "C0051960#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1522210", "name": "C1522210#ent", "pos": [19, 20]}}
{"token": ["The", "C0051960#ent", "<e1>", ",", "of", "which", "C1522210#ent", "<e2>", "is", "a", "member", ",", "were", "synthesized", "in", "an", "attempt", "to", "eliminate", "this", "toxicity", "."], "h": {"id": "C0051960", "name": "C0051960#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1522210", "name": "C1522210#ent", "pos": [6, 7]}}
{"token": ["Accordingly", ",", "earlier", "intervention", "to", "metabolic", "disorders", "C3494348#ent", "<e1>", "for", "angiotensin", "II", "aldosterone", "may", "prevent", "CKD", "as", "well", "as", "C0007222#ent", "<e2>", "associated", "with", "CKD", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [19, 20]}}
{"token": ["Clinicians", "who", "treat", "patients", "with", "C0035086#ent", "<e1>", "neurosurgeons", "who", "treat", "C0037933#ent", "<e2>", "be", "aware", "of", "dialysis-associated", "spondylarthropathy", "as", "a", "potential", "cause", "of", "degenerative", "vertebral", "column", "instability", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037933", "name": "C0037933#ent", "pos": [10, 11]}}
{"token": ["Targeted", "replacement", "these", "C3539947#ent", "<e1>", "non-modifiable", "residues", "significantly", "reduced", "the", "ability", "of", "C1416850#ent", "<e2>", "to", "activate", "both", "synthetic", "and", "pituitary", "hormone", "reporter", "genes"], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416850", "name": "C1416850#ent", "pos": [12, 13]}}
{"token": ["The", "mean", "C0720099#ent", "<e1>", "of", "the", "course", "of", "C0008809#ent", "<e2>", "was", "14", "days", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [8, 9]}}
{"token": ["The", "clinical", "features", "of", "a", "functional", "knockout", "of", "C1418612#ent", "<e1>", "are", "a", "combination", "of", "skin", "fragility", "a", "form", "of", "C0162359#ent", "<e2>"], "h": {"id": "C1418612", "name": "C1418612#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162359", "name": "C0162359#ent", "pos": [19, 20]}}
{"token": ["Consistent", "with", "a", "healthy", "C1416602#ent", "<e1>", "expression", "in", "old", "cerebral", "arteries", "C3537389#ent", "<e2>", "current", "density", ",", "kinetics", "and", "Ca(2+)", "sensitivity", "were", "practically", "identical", "in", "young", "and", "old", "myocytes", "."], "h": {"id": "C1416602", "name": "C1416602#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537389", "name": "C3537389#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "report", "a", "long-lasting", "deficit", "in", "gene", "expression", "C1416602#ent", "<e1>", "the", "large-conductance", "calcium-activated", "potassium", "BK", ",", "C3537389#ent", "<e2>", ")", "channel", "alpha-subunits", "after", "pilocarpine-induced", "status", "epilepticus", "."], "h": {"id": "C1416602", "name": "C1416602#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3537389", "name": "C3537389#ent", "pos": [18, 19]}}
{"token": ["Further", "surface", "plasmon", "resonance", "studies", "that", "the", "cytodomain", "of", "the", "C1416496#ent", "<e1>", "with", "low", "affinity", "with", "the", "cytoplasmic", "tail", "the", "C1416486#ent", "<e2>", "but", "not", "with", "that", "of", "several", "other", "alpha", "subunits", "alpha", "6"], "h": {"id": "C1416496", "name": "C1416496#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416486", "name": "C1416486#ent", "pos": [20, 21]}}
{"token": ["Our", "data", "demonstrate", "a", "decisive", "role", "for", "C1423693#ent", "<e1>", "in", "HIV-1", "transmission", "during", "genital", "coinfections", "suggest", "C0003209#ent", "<e2>", "potential", "strategies", "to", "prevent", "HIV-1", "transmission", "."], "h": {"id": "C1423693", "name": "C1423693#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003209", "name": "C0003209#ent", "pos": [16, 17]}}
{"token": ["A", "novel", "cyclic", "peptide", "C0391241#ent", "<e1>", ",", "was", "isolated", "from", "the", "culture", "broth", "an", "C0001255#ent", "<e2>", ",", "Streptomyces", "sp.", "M-271", "as", "an", "inhibitor", "of", "smooth", "muscle", "myosin", "light", "chain", "kinase", "MLCK", ")", "."], "h": {"id": "C0391241", "name": "C0391241#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001255", "name": "C0001255#ent", "pos": [14, 15]}}
{"token": ["The", "findings", "suggest", "that", "metabolites", "of", "the", "cyclooxygenase", "pathway", "involved", "in", "the", "regulation", "of", "enhanced", "intraocular", "fluid-induced", "fibroblast", "proliferation", "in", "C0242852#ent", "<e1>", "that", "acetylsalicylic", "acid", "be", "useful", "as", "an", "C0003392#ent", "<e2>", "intraocular", "fibrogenesis"], "h": {"id": "C0242852", "name": "C0242852#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [29, 30]}}
{"token": ["The", "DEAD", "box", "protein", "C3273424#ent", "<e1>", ",", "is", "an", "established", "C0073438#ent", "<e2>", "RNA", "helicase", "in", "vitro", "but", "neither", "the", "physiological", "function", "this", "protein", "nor", "the", "macromolecules", "with", "which", "it", "interacts", "are", "known", "."], "h": {"id": "C3273424", "name": "C3273424#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0073438", "name": "C0073438#ent", "pos": [10, 11]}}
{"token": ["DNA-dependent", "protein", "kinase", "C1528018#ent", "<e1>", ")", "is", "a", "C1420479#ent", "<e2>", "has", "critical", "roles", "in", "DNA", "double-strand", "break", "repair", "as", "well", "as", "B-", "and", "T-cell", "antigen", "receptor", "."], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420479", "name": "C1420479#ent", "pos": [8, 9]}}
{"token": ["Adverse", "effects", "C0546873#ent", "<e1>", "gastrointestinal", "effects", "precipitation", "of", "C0740903#ent", "<e2>", "and", "potential", "for", "hepatotoxicity", "."], "h": {"id": "C0546873", "name": "C0546873#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0740903", "name": "C0740903#ent", "pos": [8, 9]}}
{"token": ["tpl-2", "is", "a", "rat", "gene", "that", "encodes", "a", "C0072402#ent", "<e1>", "can", "act", "as", "a", "novel", "mitogen-activated", "protein", "MAP", ")", "C0031727#ent", "<e2>"], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [8, 9]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}}
{"token": ["In", "agreement", "with", "this", "conclusion", ",", "the", "acc2", "acetyl-CoA", "carboxylase", "be", "activated", ",", "in", "the", "presence", "of", "biotin", "and", "ATP", ",", "by", "C1334397#ent", "<e1>", "preparations", "from", "wild-type", "or", "C3541857#ent", "<e2>", "mutant", "cells"], "h": {"id": "C1334397", "name": "C1334397#ent", "pos": [22, 23]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3541857", "name": "C3541857#ent", "pos": [28, 29]}}
{"token": ["Choline", "kinase", "C1872855#ent", "<e1>", "was", "completely", "soluble", ",", "while", "C3538970#ent", "<e2>", "EC", "2.7.7.15", ")", "and", "phosphorylcholine-glyceride", "transferase", "EC", "2.7.8.2", ")", "were", "associated", "with", "particulate", "fractions", "."], "h": {"id": "C1872855", "name": "C1872855#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3538970", "name": "C3538970#ent", "pos": [9, 10]}}
{"token": ["Here", ",", "we", "show", "that", "palmitoylated", "C1414926#ent", "<e1>", "colocalizes", "with", "the", "small", "GTP-binding", "protein", "C1419212#ent", "<e2>", "in", "Golgi", "membranes", "in", "axons", "but", "not", "in", "dendrites", "."], "h": {"id": "C1414926", "name": "C1414926#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419212", "name": "C1419212#ent", "pos": [14, 15]}}
{"token": ["Respiratory", "diseases", "which", "have", "consequences", "for", "both", "mortality", "and", "disability", ",", "C2827557#ent", "<e1>", "third", "among", "C2963170#ent", "<e2>", "malignant", "neoplasms", "fourth", "because", "of", "their", "relatively", "small", "effect", "terms", "of", "disability", "."], "h": {"id": "C2827557", "name": "C2827557#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2963170", "name": "C2963170#ent", "pos": [15, 16]}}
{"token": ["To", "gain", "insight", "into", "the", "uptake", "of", "mature", "aspartate", "aminotransferase", "isolated", "mitochondria", ",", "the", "capability", "of", "certain", "cyanogen", "bromide", "C0030956#ent", "<e1>", "from", "mature", "beef", "heart", "C0684153#ent", "<e2>", "inhibit", "enzyme", "uptake", "was", "kinetically", "tested", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0684153", "name": "C0684153#ent", "pos": [25, 26]}}
{"token": ["Both", "short-", "and", "long-term", "C0011849#ent", "<e1>", "was", "associated", "with", "reduced", "gene", "and", "protein", "expression", "the", "three", "renal", "C0029279#ent", "<e2>", "isotypes", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029279", "name": "C0029279#ent", "pos": [17, 18]}}
{"token": ["During", "its", "route", "towards", "secretion", ",", "BSDL", "is", "associated", "with", "intracellular", "membranes", "by", "means", "of", "a", "C0751283#ent", "<e1>", "which", "includes", "the", "glucose-regulated", "protein", "94", "kDa", "(", "C3889457#ent", "<e2>", ")", "."], "h": {"id": "C0751283", "name": "C0751283#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3889457", "name": "C3889457#ent", "pos": [26, 27]}}
{"token": ["The", "C1418396#ent", "<e1>", "promoter", ",", "in", "a", "C1539598#ent", "<e2>", ",", "efficiently", "directed", "expression", "of", "murine", "erythropoietin", "in", "MLE-12", "cells", "."], "h": {"id": "C1418396", "name": "C1418396#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1539598", "name": "C1539598#ent", "pos": [7, 8]}}
{"token": ["Report", "of", "a", "case", "of", "linear", "nevus", "sebaceous", "of", "Jadassohn", "with", "the", "C0431375#ent", "<e1>", "1", ")", "the", "facial", "linear", "nevus", ";", "2", ")", "C0751495#ent", "<e2>", "3", ")", "mental", "retardation"], "h": {"id": "C0431375", "name": "C0431375#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [23, 24]}}
{"token": ["Adverse", "events", "associated", "with", "alpha-", "and", "beta-blocking", "effects", "of", "the", "C1254351#ent", "<e1>", "occurred", "more", "commonly", "with", "C0054836#ent", "<e2>", "than", "with", "placebo", ",", "whereas", "placebo", "recipients", "were", "more", "likely", "to", "experience", "worsening", "heart", "failure"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0054836", "name": "C0054836#ent", "pos": [16, 17]}}
{"token": ["The", "ability", "of", "this", "preparation", "to", "form", "phosphoenzyme", "on", "incubation", "with", "[gamma-32P]ATP", "and", "to", "bind", "C0029904#ent", "<e1>", "was", "studied", "when", "its", "C0007804#ent", "<e2>", "was", "hydrolyzed", "by", "arylsulfatase", "treatment"], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [21, 22]}}
{"token": ["The", "C0086903#ent", "<e1>", "GPR", ")", "motif", "in", "C1425135#ent", "<e2>", "was", "recently", "identified", "as", "a", "region", "for", "protein", "binding", "heterotrimeric", "G-protein", "alpha", "subunits"], "h": {"id": "C0086903", "name": "C0086903#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1425135", "name": "C1425135#ent", "pos": [7, 8]}}
{"token": ["Our", "results", "reveal", "a", "novel", ",", "phosphorylation-dependent", "regulatory", "mechanism", "targeting", "C2985456#ent", "<e1>", "through", "which", "C3890185#ent", "<e2>", "acts", "as", "a", "downstream", "effector", "of", "Ras", "to", "facilitate", "IL-2-dependent", "proliferation", "and/or", "survival", "of", "lymphoid", "cells"], "h": {"id": "C2985456", "name": "C2985456#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3890185", "name": "C3890185#ent", "pos": [14, 15]}}
{"token": ["VPA-induced", "activation", "of", "ERK", "was", "blocked", "by", "the", "mitogen-activated", "protein", "kinase/ERK", "kinase", "inhibitor", "PD098059", "and", "dominant-negative", "Ras", "and", "C1706586#ent", "<e1>", "mutants", "but", "not", "by", "C0291988#ent", "<e2>", "mitogen-activated", "protein", "kinase", "kinase", "6", "mutants", "."], "h": {"id": "C1706586", "name": "C1706586#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0291988", "name": "C0291988#ent", "pos": [24, 25]}}
{"token": ["The", "effect", "of", "C1705340#ent", "<e1>", "on", "invertebrate", "central", "neurons", "the", "C0085648#ent", "<e2>", "Helisoma", "trivolvis", "snails", "was", "examined", "in", "the", "present", "study", "."], "h": {"id": "C1705340", "name": "C1705340#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085648", "name": "C0085648#ent", "pos": [10, 11]}}
{"token": ["In", "vitro", "HGF", "directly", "attenuates", "chemotaxis", "of", "eosinophils", "in", "the", "absence", "of", "Th2", "cytokines", "and", "modulates", "C0169101#ent", "<e1>", "which", "play", "an", "important", "role", "in", "C0014457#ent", "<e2>", "migration", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [24, 25]}}
{"token": ["However", ",", "C1709384#ent", "<e1>", "inhibition", "by", "C0047215#ent", "<e2>", "or", "NU1025", "did", "not", "result", "in", "significant", "cell", "death", "CAPAN1", "cells", "."], "h": {"id": "C1709384", "name": "C1709384#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0047215", "name": "C0047215#ent", "pos": [6, 7]}}
{"token": ["This", "study", "was", "performed", "to", "evaluate", "the", "efficacy", "and", "safety", "of", "C0001641#ent", "<e1>", "terazosin", "and", "C0051150#ent", "<e2>", ")", "in", "ambulatory", "patients", "(", "n", "=", "20", ")", "with", "BPH", "."], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0051150", "name": "C0051150#ent", "pos": [15, 16]}}
{"token": ["The", "facultative", "anaerobes", "Staph", "aureus", "Staph", "epidermidis", "C0032302#ent", "<e1>", "proteus", "appeared", "as", "the", "exogenous", "agents", "of", "C0205721#ent", "<e2>"], "h": {"id": "C0032302", "name": "C0032302#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0205721", "name": "C0205721#ent", "pos": [16, 17]}}
{"token": ["As", "C1420175#ent", "<e1>", "accumulates", "in", "the", "plasma", "membrane", "it", "is", "also", "C2350558#ent", "<e2>", "in", "punctate", "structures", "the", "cell", "surface"], "h": {"id": "C1420175", "name": "C1420175#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "our", "results", "demonstrate", "that", "C1335222#ent", "<e1>", "is", "a", "target", "of", "the", "class", "III", "deacetylase", "C1423062#ent", "<e2>", "and", "identify", "a", "new", "posttranslational", "modification", "step", "in", "the", "P53-HIC1-SIRT1", "regulatory", "loop", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423062", "name": "C1423062#ent", "pos": [16, 17]}}
{"token": ["C0268800#ent", "<e1>", "development", "in", "C3149841#ent", "<e2>", "PKD", ")", "involves", "hyperplastic", "growth", "extensive", "membrane", "alterations", "suggesting", "abnormal", "membrane", "composition", "function", "."], "h": {"id": "C0268800", "name": "C0268800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [4, 5]}}
{"token": ["We", "also", "observed", "that", "TSA", "transiently", "induced", "C1332416#ent", "<e1>", "expression", "that", "had", "been", "inhibited", "by", "C0258114#ent", "<e2>", "and", "LY294002", ",", "suggesting", "that", "TSA-induced", "C1332416#ent", "<e1>", "expression", "is", "mediated", "by", "EGFR/PI3", "kinase", "pathway", "."], "h": {"id": "C0258114", "name": "C0258114#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [7, 8]}}
{"token": ["The", "reactions", "of", "C1413943#ent", "<e1>", "DDC", ")", "with", "l-", "and", "d-enantiomers", "of", "C0066289#ent", "<e2>", "described", "."], "h": {"id": "C1413943", "name": "C1413943#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0066289", "name": "C0066289#ent", "pos": [12, 13]}}
{"token": ["Adrenalectomy", ",", "demedullation", "and", "pretreatment", "with", "reserpine", ",", "C0733398#ent", "<e1>", ",", "nicotinamide", "and", "C3536880#ent", "<e2>", "blocked", "the", "hyperglycaemic", "response", "guanethidine", "and", "propranolol", "or", "oxprenolol", "were", "ineffective", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536880", "name": "C3536880#ent", "pos": [13, 14]}}
{"token": ["Microalbuminuria", "is", "also", "characterised", "by", "an", "increased", "prevalence", "of", "C0020538#ent", "<e1>", "proliferative", "retinopathy", "blindness", ",", "and", "C0235025#ent", "<e2>"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [16, 17]}}
{"token": ["Spastic", "paraplegia", "type", "7", "SPG7", ")", "is", "an", "autosomal", "recessive", "form", "C0037773#ent", "<e1>", "ARHSP", ")", "caused", "by", "mutations", "in", "C0030486#ent", "<e2>", ",", "a", "subunit", "of", "an", "ATP-dependent", "AAA-protease", "located", "within", "the", "inner", "mitochondrial", "membrane"], "h": {"id": "C0037773", "name": "C0037773#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030486", "name": "C0030486#ent", "pos": [19, 20]}}
{"token": ["C0006945#ent", "<e1>", "inhibited", "the", "positive", "inotropic", "effect", "C3273483#ent", "<e2>", "-8212", "on", "ventricular", "myocardium"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273483", "name": "C3273483#ent", "pos": [7, 8]}}
{"token": ["C1412186#ent", "<e1>", "was", "performed", "with", "a", "mixture", "of", "lipiodol", ",", "C1706799#ent", "<e2>", "and", "mitomycin", "followed", "by", "microspheres", "as", "devascularizing", "material", "."], "h": {"id": "C1412186", "name": "C1412186#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706799", "name": "C1706799#ent", "pos": [10, 11]}}
{"token": ["Cell", "capacity", "efflux", "adriamycin", "decreased", "markedly", "in", "C1421863#ent", "<e1>", "siRNA", "transfectants", ",", "and", "correlation", "between", "C1421863#ent", "<e1>", "down-regulation", "and", "increased", "multidrug", "resistance", "1", "C0376622#ent", "<e1>", ")", "gene", "transcriptional", "activity", "observed", "."], "h": {"id": "C1421863", "name": "C1421863#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0376622", "name": "C0376622#ent", "pos": [23, 24]}}
{"token": ["After", "cisplatin", "treatment", ",", "C0010763#ent", "<e1>", "a", "significant", "increase", ",", "whereas", "C1824837#ent", "<e2>", "decreased", "."], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1824837", "name": "C1824837#ent", "pos": [11, 12]}}
{"token": ["C1414404#ent", "<e1>", "exposure", "2", "24", "h", "after", "C1420066#ent", "<e2>", "appeared", "to", "increase", "in", "the", "lavage", "fluid", "levels", "of", "lysosomal", "enzymes", "at", "the", "same", "time", "decrease", "levels", "of", "PMN", "chemotactins", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [7, 8]}}
{"token": ["C57BI/6", "mice", "were", "injected", "intratracheally", "(", "IT", ")", "with", "2.0", "mg", "silica", "particles", "C1420066#ent", "<e1>", ")", "and", "subsequently", "exposed", "to", "ppm", "C1414404#ent", "<e2>", "(", "or", "filtered", "air", "within", "2", "or", "24", "h", "after", "C1420066#ent", "<e1>", "."], "h": {"id": "C1414404", "name": "C1414404#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [13, 14]}}
{"token": ["Activation", "of", "PAR1", ",", "PAR2", "and", "C3540804#ent", "<e1>", "either", "by", "C0030946#ent", "<e2>", "or", "by", "selective", "agonists", "causes", "inflammation", "inducing", "most", "of", "the", "cardinal", "signs", "inflammation", ":", "swelling", ",", "redness", ",", "and", "pain", "."], "h": {"id": "C3540804", "name": "C3540804#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [10, 11]}}
{"token": ["These", "results", "indicate", "an", "improvement", "in", "insulin", "sensitivity", "with", "C0006938#ent", "<e1>", "and", "a", "deterioration", "with", "C0004147#ent", "<e2>", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [15, 16]}}
{"token": ["Complementation", "analysis", "relevant", "subcloned", "C0011522#ent", "<e1>", "indicated", "that", "the", "three", "physically", "separated", "blocks", "of", "C0033993#ent", "<e2>", "distinct", "complementation", "groups", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [14, 15]}}
{"token": ["A", "clinical", "relevance", "these", "findings", "is", "supported", "by", "a", "marked", "upregulation", "of", "Tlr4", "mRNA", "in", "C1364818#ent", "<e1>", "transgenic", "mice", "by", "an", "increased", "expression", "of", "C1705581#ent", "<e2>", "in", "Alzheimer's", "disease", "brain", "tissue", "associated", "with", "amyloid", "plaque", "deposition", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705581", "name": "C1705581#ent", "pos": [24, 25]}}
{"token": ["The", "aim", "of", "this", "study", "is", "to", "evaluate", "the", "reliability", "of", "a", "self-administered", "questionnaire", "C0231218#ent", "<e1>", "restlessness", "as", "a", "screening", "tool", "C3888109#ent", "<e2>", "RLS", ")", "in", "a", "population", "of", "chronically", "dialyzed", "patients", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3888109", "name": "C3888109#ent", "pos": [21, 22]}}
{"token": ["The", "effects", "of", "atropine", "and", "C3814772#ent", "<e1>", ",", "when", "given", "intravenously", "with", "C0027679#ent", "<e2>", "during", "the", "reversal", "of", "neuromuscular", "blockade", "patients", "with", "cardiovascular", "disease", "were", "compared", "in", "a", "double", "blind", "trial"], "h": {"id": "C3814772", "name": "C3814772#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027679", "name": "C0027679#ent", "pos": [12, 13]}}
{"token": ["C2757070#ent", "<e1>", "accumulation", "in", "vitro", "compared", "with", "cells", "treated", "with", "C0086214#ent", "<e2>", "CC", ")", "and", "gonadotropins", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086214", "name": "C0086214#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "describe", "five", "tandemly", "arranged", "and", "converging", "C0341703#ent", "<e1>", "in", "Acinetobacter", "sp.", "BD413", "namely", "lytB", ",", "orfY", ",", "C1412821#ent", "<e2>", ",", "comB", ",", "and", "orfZ", ",", "located", "upstream", "of", "the", "previously", "identified", "competence", "gene", "comC."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [19, 20]}}
{"token": ["A", "2.7-kb", "DNA", "fragment", "was", "analyzed", "comprising", "three", "C0341703#ent", "<e1>", "(", "ppm", ",", "ppd", ",", "C1412821#ent", "<e2>", ")", "which", "are", "probably", "translationally", "coupled", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "the", "C0751837#ent", "<e1>", "form", "of", "C0017495#ent", "<e2>", "a", "rare", "human", "neurodegenerative", "disorder", "has", "been", "defined", "as", "an", "autosomal", "dominant", "disorder", "a", "PrP", "mis-sense", "mutation", "at", "codon", "102", "linked", "to", "the", "predisposition", "locus", "."], "h": {"id": "C0751837", "name": "C0751837#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0017495", "name": "C0017495#ent", "pos": [7, 8]}}
{"token": ["These", "C0149649#ent", "<e1>", "induced", "by", "therapy", "with", "C0031444#ent", "<e2>", "(", "a", "coumarin", "derivative", ",", "which", "had", "been", "initiated", "5", "months", "previously", "."], "h": {"id": "C0149649", "name": "C0149649#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031444", "name": "C0031444#ent", "pos": [7, 8]}}
{"token": ["Certain", "cutaneous", "C0042769#ent", "<e1>", "such", "as", "Herpes", "simplex", "vaccinia", "and", "C0586989#ent", "<e2>", "known", "to", "occasionally", "run", "an", "usually", "severe", "course", "in", "AD", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0586989", "name": "C0586989#ent", "pos": [10, 11]}}
{"token": ["These", "syndromes", "include", "C0149649#ent", "<e1>", "fibromuscular", "dysplasia", "antiphospholipid", "syndrome", "ergotism", ",", "neurofibromatosis", ",", "and", "C0268381#ent", "<e2>"], "h": {"id": "C0149649", "name": "C0149649#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268381", "name": "C0268381#ent", "pos": [14, 15]}}
{"token": ["Aspiration", "pneumonia", "a", "major", "cause", "of", "death", "in", "patients", "with", "C0011168#ent", "<e1>", ",", "often", "accompanied", "by", "C0233401#ent", "<e2>"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0233401", "name": "C0233401#ent", "pos": [16, 17]}}
{"token": ["Although", "such", "a", "role", "for", "C3812695#ent", "<e1>", "has", "been", "implicated", "in", "the", "intestinal", "response", "protein", "hydrolysate", "no", "C1428424#ent", "<e2>", "directly", "involved", "in", "this", "process", "has", "been", "previously", "identified", "."], "h": {"id": "C3812695", "name": "C3812695#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1428424", "name": "C1428424#ent", "pos": [17, 18]}}
{"token": ["The", "suppression", "of", "C3542399#ent", "<e1>", "induction", "by", "neurturin", "was", "mediated", "by", "activation", "of", "the", "C2936824#ent", "<e2>", "mitogen-activated", "protein", "kinase", "pathways"], "h": {"id": "C3542399", "name": "C3542399#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [14, 15]}}
{"token": ["Idiopathic", "granulomatous", "mastitis", "C1706005#ent", "<e1>", ")", "is", "a", "benign", ",", "C0008679#ent", "<e2>", "often", "mistaken", "for", "breast", "cancer"], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [10, 11]}}
{"token": ["The", "median", "frequency", "MF", ")", ",", "peak", "frequency", "PF", ")", ",", "average", "segment", "amplitude", "(", "C3853627#ent", "<e1>", ")", "and", "maximum", "segment", "amplitude", "(", "C0000294#ent", "<e2>", ")", "were", "studied", "."], "h": {"id": "C3853627", "name": "C3853627#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0000294", "name": "C0000294#ent", "pos": [23, 24]}}
{"token": ["C0796028#ent", "<e1>", "RS", ")", "is", "associated", "with", "characteristic", "C0907533#ent", "<e2>", "heterochromatin", "anomaly", "namely", ",", "at", "metaphase", "the", "centromeres", "and", "heterochromatic", "segments", "appear", "split", "."], "h": {"id": "C0796028", "name": "C0796028#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}}
{"token": ["The", "review", "addresses", "the", "therapeutic", "options", "in", "C0521516#ent", "<e1>", "rheumatica", ",", "and", "focuses", "on", "oral", "corticosteroids", "intramuscular", "and", "intravenous", "C0360556#ent", "<e2>", ",", "deflazacort", ",", "and", "methotrexate", "."], "h": {"id": "C0521516", "name": "C0521516#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0360556", "name": "C0360556#ent", "pos": [19, 20]}}
{"token": ["Twenty", "patients", "with", "known", "malignant", "disease", "C0020437#ent", "<e1>", "were", "randomly", "assigned", "on", "a", "2:1", "basis", "to", "C0086268#ent", "<e2>", "7.5", "mg", "kg-1", "body", "weight", "or", "placebo", "for", "3", "-", "5", "days", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0086268", "name": "C0086268#ent", "pos": [16, 17]}}
{"token": ["Homologous", "sequences", "discovered", "within", "the", "C0242965#ent", "<e1>", "of", "all", "but", "one", "species", "of", "C0038041#ent", "<e2>", "Rickettsiae", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038041", "name": "C0038041#ent", "pos": [13, 14]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "assess", "markers", "of", "inflammation", ",", "C0029408#ent", "<e1>", "and", "pain", "in", "rats", "with", "adjuvant", "arthritis", "treatment", "with", "C0020740#ent", "<e2>", "Dolgit", "cream", ")", "and", "placebo", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [22, 23]}}
{"token": ["(", "1", ")", "The", "reference", "treatment", "drug-based", "symptomatic", "relief", "of", "C0029408#ent", "<e1>", "and", "rheumatoid", "arthritis", "paracetamol", "and", "low-dose", "C0020740#ent", "<e2>", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [18, 19]}}
{"token": ["To", "investigate", "the", "effect", "of", "C3640937#ent", "<e1>", "Injection", "(", "SMI", ")", "on", "blood", "coagulation", "patients", "with", "chronic", "heart", "failure", "C0019099#ent", "<e2>", ")", "."], "h": {"id": "C3640937", "name": "C3640937#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [19, 20]}}
{"token": ["The", "mean", "plasma", "clearances", "of", "C0008241#ent", "<e1>", "for", "EMs", "and", "C0033046#ent", "<e2>", "were", "1.31", "and", "1.10", "L/hr/kg", ",", "respectively", "."], "h": {"id": "C0008241", "name": "C0008241#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033046", "name": "C0033046#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "examine", "the", "level", "of", "sICAM-1", "in", "serum", "of", "patients", "suffering", "from", "C2607914#ent", "<e1>", "treated", "with", "fexofenadine", "or", "C0082607#ent", "<e2>", "."], "h": {"id": "C2607914", "name": "C2607914#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0082607", "name": "C0082607#ent", "pos": [24, 25]}}
{"token": ["Cocaine", "was", "found", "to", "undergo", "conversion", "to", "C0068972#ent", "<e1>", "by", "two", "alternate", "pathways", ",", "one", "involving", "only", "C0051169#ent", "<e2>", "the", "other", "requiring", "both", "C0051169#ent", "<e2>", "FAD-containing", "monooxygenase"], "h": {"id": "C0068972", "name": "C0068972#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [17, 18]}}
{"token": ["The", "localization", "pattern", "of", "Fras1", "and", "C1539531#ent", "<e1>", "was", "indistinguishable", ",", "while", "both", "proteins", "along", "with", "C1539532#ent", "<e2>", "could", "be", "detected", "even", "in", "the", "absence", "of", "Frem1", "."], "h": {"id": "C1539531", "name": "C1539531#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539532", "name": "C1539532#ent", "pos": [16, 17]}}
{"token": ["We", "also", "identified", "C0034678#ent", "<e1>", "mutations", "in", "ten", "patients", "and", "C1333568#ent", "<e2>", "internal", "tandem", "duplication", "(", "FLT3/ITD", ")", "in", "one", "patient", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333568", "name": "C1333568#ent", "pos": [10, 11]}}
{"token": ["Also", "the", "size", ",", "C2926735#ent", "<e1>", "and", "the", "severity", "of", "the", "inflammation", "reaction", "the", "C0042344#ent", "<e2>", "comparable", "before", "the", "start", "of", "the", "therapy", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042344", "name": "C0042344#ent", "pos": [14, 15]}}
{"token": ["A", "set", "of", "activity", "assays", "using", "various", "substrates", ",", "C1258127#ent", "<e1>", ",", "and", "an", "inhibitor", "to", "distinguish", "C1412333#ent", "<e2>", ",", "ALDH2", ",", "ALDH3", ",", "and", "ALDH4", "is", "presented", "."], "h": {"id": "C1258127", "name": "C1258127#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412333", "name": "C1412333#ent", "pos": [17, 18]}}
{"token": ["A", "comparison", "of", "these", "four", "patients", "with", "patients", "who", "had", "bullous", "pemphigoid", "C0038013#ent", "<e1>", "similarities", "between", "C0030804#ent", "<e2>", "bullous", "pemphigoid", "relation", "to", "the", "development", "of", "C0038013#ent", "<e1>"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030804", "name": "C0030804#ent", "pos": [16, 17]}}
{"token": ["C0031456#ent", "<e1>", "PAH", ")", "is", "a", "tetrahydrobiopterin-dependent", ",", "nonheme", "C0027203#ent", "<e2>", "catalyzes", "the", "hydroxylation", "of", "L-Phe", "to", "L-Tyr", "in", "the", "rate-limiting", "step", "of", "phenylalanine", "catabolism"], "h": {"id": "C0031456", "name": "C0031456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["Results", "from", "experiments", "using", "[2", "-", "14C]m-tyrosine", "enantiomers", "and", "specific", "enzyme", "inhibitors", "that", "C0031456#ent", "<e1>", "be", "the", "C0027203#ent", "<e2>", "catalyzing", "this", "reaction", "."], "h": {"id": "C0031456", "name": "C0031456#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}}
{"token": ["The", "incorporation", "rate", "of", "C0066485#ent", "<e1>", "into", "pregnenolone", "was", "also", "increased", "by", "the", "stimulation", "of", "C1382029#ent", "<e2>", "in", "intact", "C6", "cells", "."], "h": {"id": "C0066485", "name": "C0066485#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [15, 16]}}
{"token": ["These", "data", "together", "suggest", "that", "the", "actin", "filament", "binding", "activity", "N-WASP", "and", "C4084757#ent", "<e1>", "in", "the", "basic", "region", "increases", "the", "number", "of", "C0687751#ent", "<e2>", "ends", "created", "on", "pre-existing", "filaments", "."], "h": {"id": "C4084757", "name": "C4084757#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0687751", "name": "C0687751#ent", "pos": [22, 23]}}
{"token": ["Expression", "of", "the", "C1422190#ent", "<e1>", "sulA", ")", "was", "assayed", "by", "monitoring", "the", "levels", "of", "C0005220#ent", "<e2>", "."], "h": {"id": "C1422190", "name": "C1422190#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [14, 15]}}
{"token": ["The", "flux", "rates", "deepithelialized", "corneas", "in", "the", "presence", "of", "C1412332#ent", "<e1>", ",", "with", "or", "without", "C0007907#ent", "<e2>", "were", "similar", "to", "fluxes", "found", "in", "the", "absence", "of", "C1412332#ent", "<e1>", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007907", "name": "C0007907#ent", "pos": [15, 16]}}
{"token": ["Extreme", "degrees", "hypoxanthine", "phosphoribosyltransferase", "HPRT", ")", "deficiency", "in", "man", "are", "associated", "with", "gross", "sex-linked", "neurological", "dysfunction", "C0018099#ent", "<e1>", "and", "urinary", "stones", "the", "C1415701#ent", "<e2>", "or", "'", "complete", "HPRT-deficiency", "'", "syndrome", ")", "."], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [16, 17]}, "relation": "disease_has_associated_gene", "t": {"id": "C1415701", "name": "C1415701#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "whether", "C1257968#ent", "<e1>", "stimulates", "pregnane", "X", "receptor", "transcription", "of", "C3714798#ent", "<e2>", "."], "h": {"id": "C1257968", "name": "C1257968#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "impact", "of", "C0029051#ent", "<e1>", "on", "ovarian", "function", "on", "two", "murine", "C0004364#ent", "<e2>", "AOD", ")", "models", "."], "h": {"id": "C0029051", "name": "C0029051#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [16, 17]}}
{"token": ["The", "circulating", "iPTH", "at", "24", "h", "was", "inversely", "related", "to", "the", "corresponding", "plasma", "ionised", "C2936886#ent", "<e1>", "concentration", "and", "had", "C0246719#ent", "<e2>", "above", "preinfusion", "values", "that", "time", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0246719", "name": "C0246719#ent", "pos": [19, 20]}}
{"token": ["An", "80-year-old", "woman", "with", "C0026919#ent", "<e1>", "treated", "with", "combined", "chemotherapy", "including", "isoniazid", ",", "rifampicin", ",", "and", "C0546863#ent", "<e2>", "."], "h": {"id": "C0026919", "name": "C0026919#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0546863", "name": "C0546863#ent", "pos": [16, 17]}}
{"token": ["These", "studies", "indicate", "that", "each", "C1538917#ent", "<e1>", "a", "characteristic", "pattern", "of", "expression", "in", "the", "epididymis", ";", "C3853563#ent", "<e2>", "in", "particular", "may", "play", "a", "unique", "regulatory", "role", "the", "regionalized", "functions", "of", "the", "epididymis", "."], "h": {"id": "C1538917", "name": "C1538917#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853563", "name": "C3853563#ent", "pos": [16, 17]}}
{"token": ["This", "protein", "(", "TnpI", ")", "displays", "regional", "similarities", "with", "C0527356#ent", "<e1>", "the", "integrase", "family", "such", "as", "Int", "of", "bacteriophage", "lambda", "C1511573#ent", "<e2>", "of", "bacteriophage", "P1", "TnpA", "and", "TnpB", "of", "the", "Tn554", "transposon", "."], "h": {"id": "C0527356", "name": "C0527356#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [20, 21]}}
{"token": ["C0935929#ent", "<e1>", "principally", "the", "sulphonylureas", "and", "C0360396#ent", "<e2>", ",", "are", "often", "only", "partially", "effective", ",", "even", "in", "combination", "."], "h": {"id": "C0935929", "name": "C0935929#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0360396", "name": "C0360396#ent", "pos": [6, 7]}}
{"token": ["C1822758#ent", "<e1>", "belongs", "to", "the", "C1099413#ent", "<e2>", "which", "takes", "up", "choline", "."], "h": {"id": "C1822758", "name": "C1822758#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1099413", "name": "C1099413#ent", "pos": [5, 6]}}
{"token": ["SBTI", "administration", "for", "48h", "resulted", "in", "nonparallel", "regulation", "of", "C1333402#ent", "<e1>", ",", "as", "assessed", "by", "slot-blot", "analysis", "using", "cloned", "cDNA", "probes", "C0960371#ent", "<e2>", ",", "chymotrypsin", ",", "amylase", "and", "ribonuclease", "."], "h": {"id": "C1333402", "name": "C1333402#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [21, 22]}}
{"token": ["Untreated", "SHR", "(", "p<0.01", ")", ",", "SHR", "treated", "with", "losartan", "and", "SHR", "treated", "with", "C0037982#ent", "<e1>", "(", "p<0.05", ")", "showed", "less", "C1328053#ent", "<e2>", "as", "compared", "to", "WKY", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [21, 22]}}
{"token": ["Such", "an", "effect", "has", "been", "ascribed", "to", "APB-receptors", ",", "but", "L-2-amino-4-phosphonobutyrate", "(", "C1868120#ent", "<e1>", ")", "itself", "failed", "to", "induce", "current", "responses", "in", "C1420683#ent", "<e2>", "neurons", "."], "h": {"id": "C1868120", "name": "C1868120#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420683", "name": "C1420683#ent", "pos": [22, 23]}}
{"token": ["While", "binding", "UAS1", "poorly", ",", "C1415470#ent", "<e1>", "-", "18", "binds", "UAS(CYC7", ")", "with", "C2987364#ent", "<e2>", "properties", "and", "activates", "transcription", "at", "elevated", "levels", "relative", "to", "C1415470#ent", "<e1>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415470", "name": "C1415470#ent", "pos": [5, 6]}}
{"token": ["We", "conclude", "that", "C0038454#ent", "<e1>", "cause", "different", "C0039082#ent", "<e2>", "on", "the", "topography", "of", "the", "underlying", "lesion", "."], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [7, 8]}}
{"token": ["We", "present", "correlations", "between", "these", "mutagenesis", "data", "and", "the", "recently", "solved", "crystal", "structure", "the", "C3273758#ent", "<e1>", "with", "a", "C0030956#ent", "<e2>", "ligand", "."], "h": {"id": "C3273758", "name": "C3273758#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}}
{"token": ["Expression", "of", "the", "Fc", "receptor", "for", "IgE", "Fc", "epsilon", "R", "was", "analyzed", "on", "alveolar", "macrophages", "C3813124#ent", "<e1>", ")", "in", "10", "patients", "with", "extrinsic", "allergic", "alveolitis", "C0242900#ent", "<e2>", ")", "compared", "with", "10", "patients", "with", "sarcoidosis", "and", "to", "6", "apparently", "healthy", "controls"], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0242900", "name": "C0242900#ent", "pos": [25, 26]}}
{"token": ["6", "mg/g", "of", "dried", "gel", "and", "the", "activity", "of", "the", "bound", "C1333216#ent", "<e1>", "was", "comparable", "to", "that", "of", "the", "C0027203#ent", "<e2>"], "h": {"id": "C1333216", "name": "C1333216#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [19, 20]}}
{"token": ["Maintenance", "chemotherapy", "C0007257#ent", "<e1>", ",", "carboplatin", "and", "C0042679#ent", "<e2>", "(", "8", "cycles", "over", "a", "1-year", "period", ")", "was", "given", "in", "those", "patients", "who", "responded", "clinically", "or", "radiographically", "to", "induction", "chemotherapy"], "h": {"id": "C0007257", "name": "C0007257#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042679", "name": "C0042679#ent", "pos": [7, 8]}}
{"token": ["Aluminium", "toxicity", "occurred", "in", "two", "infants", "with", "C0158995#ent", "<e1>", "had", "never", "received", "C4020599#ent", "<e2>", "other", "aluminium-containing", "agents", "or", "intravenous", "fluids"], "h": {"id": "C0158995", "name": "C0158995#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4020599", "name": "C4020599#ent", "pos": [12, 13]}}
{"token": ["Nonrelapse", "causes", "of", "death", "included", "C0238013#ent", "<e1>", "three", ",", "multiorgan", "failure", "three", ",", "and", "C2350236#ent", "<e2>", "two", "patients", "."], "h": {"id": "C0238013", "name": "C0238013#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2350236", "name": "C2350236#ent", "pos": [14, 15]}}
{"token": ["About", "80", "%", "of", "the", "C3659502#ent", "<e1>", "activity", "and", "about", "50", "%", "of", "the", "microsomal", "C1705794#ent", "<e2>", "were", "destroyed", "."], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705794", "name": "C1705794#ent", "pos": [15, 16]}}
{"token": ["Pretreatment", "with", "the", "C0132555#ent", "<e1>", "NOS", ")", "inhibitor", "C0068821#ent", "<e2>", "L-NAME", ",", "100", "microM", ")", "abolished", "the", "inhibitory", "effect", "of", "anisodamine", "in", "cell", "shortening"], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0068821", "name": "C0068821#ent", "pos": [8, 9]}}
{"token": ["Cell", "shrinkage", ",", "elevation", "of", "cellular", "divalent", "ions", ",", "thiol", "alkylation", "C0597217#ent", "<e1>", "and", "derivatives", "of", "certain", "C0012798#ent", "<e2>", "stilbenes", "are", "inhibitory", "."], "h": {"id": "C0597217", "name": "C0597217#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [17, 18]}}
{"token": ["The", "expression", "of", "C1707172#ent", "<e1>", "and", "3", "beta-HSD", "have", "been", "demonstrated", "by", "PCR", "in", "C0001614#ent", "<e2>", ",", "cerebellum", ",", "and", "spinal", "cord"], "h": {"id": "C1707172", "name": "C1707172#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [14, 15]}}
{"token": ["Pseudohypoparathyroidism", "(", "C3539770#ent", "<e1>", ")", "type", "1b", "is", "a", "rare", "C2827454#ent", "<e2>", "characterized", "by", "renal", "resistance", "parathyroid", "hormone", "PTH", ")", "resulting", "in", "biochemical", "hypoparathyroidism", "with", "skeletal", "sensitivity", "PTH", "."], "h": {"id": "C3539770", "name": "C3539770#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2827454", "name": "C2827454#ent", "pos": [10, 11]}}
{"token": ["Tuberoinfundibular", "peptide", "of", "39", "residues", "(", "C1842125#ent", "<e1>", ")", "is", "a", "selective", "agonist", "of", "the", "C1842125#ent", "<e1>", "PTH2", ")", "receptor", "."], "h": {"id": "C1842125", "name": "C1842125#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1842125", "name": "C1842125#ent", "pos": [6, 7]}}
{"token": ["It", "is", "concluded", "that", "C3814772#ent", "<e1>", "offers", "no", "advantage", "over", "C1161352#ent", "<e2>", "with", "respect", "to", "protection", "of", "the", "bowel", "against", "the", "effects", "of", "neostigmine", "."], "h": {"id": "C3814772", "name": "C3814772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [10, 11]}}
{"token": ["The", "finding", "of", "a", "regulated", "expression", "of", "the", "iron-regulatory", "peptide", "hormone", "C1423607#ent", "<e1>", "in", "the", "heart", "suggests", "that", "C1423607#ent", "<e1>", "may", "have", "an", "important", "role", "in", "C0018824#ent", "<e1>"], "h": {"id": "C1423607", "name": "C1423607#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [26, 27]}}
{"token": ["Immune", "responses", "the", "mechanisms", "of", "tolerance", "to", "the", "common", "dietary", "antigens", "bovine", "gamma", "globulin", "C1514546#ent", "<e1>", ")", ",", "ovalbumin", "(", "OVA", ")", ",", "and", "C0677666#ent", "<e2>", "evaluated", "in", "normal", "human", "volunteers", "."], "h": {"id": "C1514546", "name": "C1514546#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0677666", "name": "C0677666#ent", "pos": [24, 25]}}
{"token": ["In", "particular", ",", "they", "target", "epidermal", "growth", "factor", "receptor", "EGFR", ",", "also", "known", "as", "C0242984#ent", "<e1>", ")", "and", "human", "C1414313#ent", "<e2>", "HER2", ",", "also", "known", "as", "ErbB-2", ")", "."], "h": {"id": "C0242984", "name": "C0242984#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414313", "name": "C1414313#ent", "pos": [19, 20]}}
{"token": ["It", "was", "concluded", "that", "both", "the", "density", "of", "the", "renal", "thiazide", "receptor", "and", "the", "quantity", "of", "C3714642#ent", "<e1>", "and", "chloride", "reabsorbed", "by", "the", "C1420092#ent", "<e2>", "the", "kidney", "are", "under", "adrenocortical", "regulation"], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420092", "name": "C1420092#ent", "pos": [23, 24]}}
{"token": ["Specific", "binding", "of", "3H-yohimbine", "was", "displaced", "effectively", "by", "C0178469#ent", "<e1>", "less", "effectively", "by", "alpha", "1", "adrenergic", "agents", "C0001637#ent", "<e2>"], "h": {"id": "C0178469", "name": "C0178469#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001637", "name": "C0001637#ent", "pos": [17, 18]}}
{"token": ["In", "Experiment", "1", "C0010592#ent", "<e1>", "was", "a", "highly", "salient", "93-dB", "tone", ",", "and", "C1413753#ent", "<e2>", "was", "a", "moderately", "salient", "flashing", "light", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413753", "name": "C1413753#ent", "pos": [13, 14]}}
{"token": ["The", "results", "obtained", "indicate", "that", "the", "C0031306#ent", "<e1>", "peripheral", "blood", "granulocytes", "in", "patients", "with", "C0038013#ent", "<e2>", "normal", "."], "h": {"id": "C0031306", "name": "C0031306#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [14, 15]}}
{"token": ["Combining", "both", "detergents", ",", "C0045733#ent", "<e1>", "and", "PAS", ",", "appeared", "to", "increase", "denaturation", "of", "C0014241#ent", "<e2>", "at", "thermophilic", "temperatures", "."], "h": {"id": "C0045733", "name": "C0045733#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014241", "name": "C0014241#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "amino-terminal", "amino", "acid", "sequence", "C1705456#ent", "<e1>", "was", "identical", "to", "that", "of", "C1705065#ent", "<e2>", ",", "and", "the", "amino-terminal", "sequence", "of", "SAP5", "was", "identical", "to", "that", "of", "SAP6", "."], "h": {"id": "C1705456", "name": "C1705456#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [15, 16]}}
{"token": ["C0796126#ent", "<e1>", "by", "itself", "did", "not", "provoke", "C0036572#ent", "<e2>", "in", "untreated", "rats", "."], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [7, 8]}}
{"token": ["C0919425#ent", "<e1>", "3'-UTR", ",", "EPHX1", "codons", "113", "and", "139", ",", "C0537086#ent", "<e2>", ",", "GSTM1", "and", "GSTT1", "metabolic", "polymorphisms", ",", "and", "XRCC3", "codon", "241", "XPD", "codon", "751", "repair", "polymorphisms", "influenced", "cytogenetic", "damage", "levels", "."], "h": {"id": "C0919425", "name": "C0919425#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0537086", "name": "C0537086#ent", "pos": [10, 11]}}
{"token": ["Acinetobacter", "lwoffii", "K24", "as", "an", "aniline", "degrading", "bacterium", "has", "also", "been", "found", "to", "utilize", "C1542030#ent", "<e1>", "as", "a", "sole", "C0524928#ent", "<e2>", "source", "."], "h": {"id": "C1542030", "name": "C1542030#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [19, 20]}}
{"token": ["The", "microscopic", "appearance", "of", "the", "uterus", "and", "the", "histologic", "examination", "the", "rupture", "sites", "are", "compatible", "with", "invasive", "placenta", "with", "signs", "of", "acute", "of", "C0149516#ent", "<e1>", "areas", "of", "C0035235#ent", "<e2>", "the", "uterus", "."], "h": {"id": "C0149516", "name": "C0149516#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0035235", "name": "C0035235#ent", "pos": [27, 28]}}
{"token": ["C1705356#ent", "<e1>", "represses", "transcription", "of", "the", "C0694889#ent", "<e2>", "only", "by", "binding", "to", "the", "FREs", ",", "but", "also", "by", "competing", "with", "Sp1", "at", "the", "GC-box", "2", "and", "the", "FRE3", "."], "h": {"id": "C1705356", "name": "C1705356#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0694889", "name": "C0694889#ent", "pos": [6, 7]}}
{"token": ["The", "chemical", "structure", "C0526114#ent", "<e1>", "remarkably", "similar", "to", "those", "of", "pseudobactin", "and", "C0072532#ent", "<e2>", "the", "siderophores", "of", "plant", "growth", "promoting", "and", "plant-deleterious", "Pseudomonas", "B10", "and", "Pseudomonas", "7SR1", "respectively", "."], "h": {"id": "C0526114", "name": "C0526114#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0072532", "name": "C0072532#ent", "pos": [12, 13]}}
{"token": ["Taken", "together", ",", "the", "results", "indicate", "that", "C0078956#ent", "<e1>", "regulates", "c-fms", "gene", "expression", "by", "a", "dexamethasone-sensitive", "mechanism", "and", "that", "C0879468#ent", "<e2>", "mRNA", "levels", "are", "controlled", "by", "metabolites", "of", "the", "arachidonic", "acid", "pathway"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0879468", "name": "C0879468#ent", "pos": [19, 20]}}
{"token": ["HLA", "antigens", "associated", "with", "number", "of", "C0033581#ent", "<e1>", "most", "notably", "HLA", "B2", "with", "C0042165#ent", "<e2>", "AU", ")", "."], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042165", "name": "C0042165#ent", "pos": [13, 14]}}
{"token": ["FTY720", "[", "2-amino-2-[2-(4-octylphenyl", ")", "ethyl]propane-1,3-diol", "hydrochloride", "]", "is", "an", "C1414253#ent", "<e1>", "under", "development", "for", "the", "treatment", "of", "C0026769#ent", "<e2>", "MS", ")", "."], "h": {"id": "C1414253", "name": "C1414253#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [17, 18]}}
{"token": ["Eight", "of", "the", "19", "dogs", "with", "Lp", "+", "C1706339#ent", "<e1>", "died", "of", "C0162557#ent", "<e2>"], "h": {"id": "C1706339", "name": "C1706339#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162557", "name": "C0162557#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "C0033798#ent", "<e1>", "and", "the", "traditional", "C0004096#ent", "<e2>", "\"", "Makyo-kanseki-to", "\"", "and", "\"", "Goko-to", "\"", "were", "therefore", "studied", "on", "such", "constitutional", "predispositions", "as", "insensible", "perspiration", "and", "body", "temperature"], "h": {"id": "C0033798", "name": "C0033798#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [8, 9]}}
{"token": ["This", "report", "suggests", "that", "the", "co-administration", "of", "C0033798#ent", "<e1>", "and", "gypsum", "is", "physiologically", "more", "desirable", "than", "C0033798#ent", "<e1>", "alone", "for", "dry-type", "C0004096#ent", "<e1>", "patients", "with", "a", "fever", "."], "h": {"id": "C0033798", "name": "C0033798#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [21, 22]}}
{"token": ["Increased", "SR", "C1413043#ent", "<e1>", "+", "was", "accompanied", "by", "increased", "frequency", "and", "amplitudes", "of", "spontaneous", "C1413043#ent", "<e1>", "+", "sparks", "measured", "at", "37", "degrees", "C", "with", "C0060505#ent", "<e1>"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0060505", "name": "C0060505#ent", "pos": [24, 25]}}
{"token": ["Titration", "of", "C1413043#ent", "<e1>", "+", "concentration", "exhibits", "a", "linear", "relationship", "increasing", "C0060505#ent", "<e2>", "AM", "fluorescence", "intensity", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0060505", "name": "C0060505#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "C0013136#ent", "<e1>", "and", "ondansetron", "are", "effective", "C0991617#ent", "<e2>", "in", "the", "prevention", "of", "PONV", ",", "and", "their", "combination", "seems", "to", "provide", "slightly", "better", "results", "than", "either", "drug", "alone", "."], "h": {"id": "C0013136", "name": "C0013136#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [9, 10]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "compare", "the", "effectiveness", "and", "safety", "of", "intramuscular", "C0013136#ent", "<e1>", "to", "other", "intramuscularly", "administered", "C0991617#ent", "<e2>", "used", "in", "the", "management", "of", "acutely", "agitated", "patients", "."], "h": {"id": "C0013136", "name": "C0013136#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [20, 21]}}
{"token": ["Case", "reports", "that", "C0162628#ent", "<e1>", "as", "cytomegalovirus", "(", "CMV", ")", "reactivation", "may", "contribute", "to", "C0012634#ent", "<e2>"], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["Ineffective", ":", "C0085752#ent", "<e1>", ",", "epirubicin", ",", "daunorubicin", ",", "C0700458#ent", "<e2>", ",", "actinomycin", "D", "etoposide", ",", "teniposide", ",", "vincristine", ",", "vinblastine", ",", "vindesine", ",", "cytarabine", ",", "cisplatin", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700458", "name": "C0700458#ent", "pos": [9, 10]}}
{"token": ["Second", ",", "the", "natural", "history", "prognosis", ",", "at", "least", "in", "the", "setting", "of", "C1290138#ent", "<e1>", "is", "worse", "than", "seen", "in", "patients", "with", "C0152171#ent", "<e2>"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0152171", "name": "C0152171#ent", "pos": [22, 23]}}
{"token": ["Six", "enzyme", "systems", "C2975867#ent", "<e1>", ",", "PGD", ",", "PGM", ",", "C2697821#ent", "<e2>", ",", "HEX", "and", "MPI", ")", "were", "consistently", "polymorphic", "and", "scorable", "and", "were", "used", "to", "quantify", "estimated", "gene", "flow", "populations", "."], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697821", "name": "C2697821#ent", "pos": [10, 11]}}
{"token": ["Among", "the", "putative", "targets", "is", "C1336571#ent", "<e1>", ",", "which", "is", "methylated", "at", "C1422497#ent", "<e2>", "by", "the", "enzyme", "in", "vitro"], "h": {"id": "C1336571", "name": "C1336571#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422497", "name": "C1422497#ent", "pos": [12, 13]}}
{"token": ["In", "a", "preliminary", "study", ",", "this", "sign", "was", "observed", "in", "patients", "with", "C0007682#ent", "<e1>", "especially", "in", "C0006111#ent", "<e2>", "of", "etiology", "."], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0006111", "name": "C0006111#ent", "pos": [16, 17]}}
{"token": ["To", "examine", "whether", "the", "metabolic", "functions", "of", "these", "C0026794#ent", "<e1>", "are", "interchangeable", ",", "we", "have", "altered", "the", "cellular", "localization", "mitochondrial", "malate", "dehydrogenase", "C1417087#ent", "<e2>", ")", "in", "yeast", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417087", "name": "C1417087#ent", "pos": [22, 23]}}
{"token": ["Persistent", "corneal", "epithelial", "defects", "C1846545#ent", "<e1>", ")", "are", "caused", "by", "many", "C0029896#ent", "<e2>", "that", "are", "usually", "associated", "with", "decreased", "production", "of", "tears", "or", "reduced", "corneal", "sensitivity"], "h": {"id": "C1846545", "name": "C1846545#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "additional", "Chinese", "hamster", "cell", "lines", "deficient", "in", "the", "Rad51", "paralogs", "Rad51C", ",", "Rad51D", ",", "Xrcc2", ",", "and", "C1337032#ent", "<e1>", "as", "well", "as", "another", "essential", "HRR", "protein", "C0598034#ent", "<e2>", "."], "h": {"id": "C1337032", "name": "C1337032#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0598034", "name": "C0598034#ent", "pos": [33, 34]}}
{"token": ["The", "crystals", "were", "non-birefringent", ",", "periodic", "acid-Schiff-negative", ",", "and", "showed", "polytypic", "reaction", "with", "both", "kappa", "and", "C0314619#ent", "<e1>", "and", "alpha", ",", "mu", ",", "and", "C0018854#ent", "<e2>"], "h": {"id": "C0314619", "name": "C0314619#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0018854", "name": "C0018854#ent", "pos": [24, 25]}}
{"token": ["C0771029#ent", "<e1>", ",", "an", "allylamine", ",", "is", "C0003308#ent", "<e2>", "and", "remains", "at", "therapeutic", "levels", "keratinized", "tissues", ",", "but", "with", "a", "short", "plasma", "half-life", "of", "36", "hours", "."], "h": {"id": "C0771029", "name": "C0771029#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [7, 8]}}
{"token": ["C0019593#ent", "<e1>", "cimetidine", ",", "famotidine", "and", "ranitidine", "were", "used", "to", "inhibit", "C0051169#ent", "<e2>", "rat", "liver", "."], "h": {"id": "C0019593", "name": "C0019593#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "if", "the", "metabolic", "abnormalities", "caused", "the", "11beta-HSD-1", "increase", ",", "C0362046#ent", "<e1>", "islets", "were", "cultured", "in", "high", "or", "low", "glucose", "in", "2:1", "C0028928#ent", "<e2>", ":", "palmitate", "for", "3", "days", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [23, 24]}}
{"token": ["To", "characterize", "minimal", "CT", "signs", "of", "initial", "C0009250#ent", "<e1>", "candidomycosis", "and", "invasive", "C0017641#ent", "<e2>", "of", "the", "lungs", "."], "h": {"id": "C0009250", "name": "C0009250#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017641", "name": "C0017641#ent", "pos": [12, 13]}}
{"token": ["Therefore", ",", "our", "results", "demonstrate", "that", "telomerase", "activity", "related", "not", "only", "to", "transcriptional", "regulation", "C1705316#ent", "<e1>", "by", "C1417708#ent", "<e2>", "but", "also", "to", "posttranscriptional", "regulation", "of", "phosphorylation", "of", "C1705316#ent", "<e1>", "by", "Akt", "kinase"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "raloxifene", "also", "inhibited", "the", "E2-induced", "phosphorylation", "of", "C1705316#ent", "<e1>", ",", "association", "of", "C1417708#ent", "<e2>", "with", "C1705316#ent", "<e1>", ",", "and", "nuclear", "accumulation", "C1705316#ent", "<e1>", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "estrogen", "induced", "the", "phosphorylation", "of", "IkappaB", "inhibitor", "protein", "the", "Akt", "cascade", "and", "cotransfection", "with", "a", "dominant-negative", "subunit", "C1417708#ent", "<e1>", "attenuated", "the", "response", "of", "the", "ERE-deleted", "C1705316#ent", "<e2>", "promoter", "to", "E(2)"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1705316", "name": "C1705316#ent", "pos": [28, 29]}}
{"token": ["It", "even", "seems", "that", "bleeding", "during", "follow-up", "in", "patients", "with", "C3149841#ent", "<e1>", "occurs", "from", "non", "previously", "demonstrated", "C0007766#ent", "<e2>", "."], "h": {"id": "C3149841", "name": "C3149841#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0007766", "name": "C0007766#ent", "pos": [17, 18]}}
{"token": ["Previous", "studies", "have", "clarified", "the", "molecular", "mechanism", "photosensitization", "on", "red", "blood", "cell", "membranes", "induced", "by", "some", "drugs", "belonging", "to", "the", "class", "of", "C0003211#ent", "<e1>", "ketoprofen", ",", "naproxen", ",", "and", "C0012228#ent", "<e2>", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [22, 23]}, "relation": "structural_class_of", "t": {"id": "C0012228", "name": "C0012228#ent", "pos": [29, 30]}}
{"token": ["In", "recent", "years", ",", "dental", "practitioners", "relied", "on", "ibuprofen", "and", "other", "nonsteroidal", "anti-inflammatory", "drugs", "or", "C0003211#ent", "<e1>", "--", "such", "as", "naproxen", ",", "C0012228#ent", "<e2>", "and", "ketoprofen", "--", "to", "manage", "acute", "and", "chronic", "orofacial", "pain"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [15, 16]}, "relation": "structural_class_of", "t": {"id": "C0012228", "name": "C0012228#ent", "pos": [22, 23]}}
{"token": ["In", "C1527231#ent", "<e1>", "(", "AMN", ")", "conventional", "MRI", "detects", "only", "C0742191#ent", "<e2>", "the", "late", "stages"], "h": {"id": "C1527231", "name": "C1527231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0742191", "name": "C0742191#ent", "pos": [10, 11]}}
{"token": ["In", "adrenomyeloneuropathy", "(", "C1527231#ent", "<e1>", ")", "conventional", "MRI", "detects", "only", "C0742191#ent", "<e2>", "the", "late", "stages"], "h": {"id": "C1527231", "name": "C1527231#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0742191", "name": "C0742191#ent", "pos": [10, 11]}}
{"token": ["PCR", "analysis", "that", "genes", "encoding", "C1412930#ent", "<e1>", "and", "Ch2", "are", "co-expressed", "in", "both", "the", "C0036091#ent", "<e2>", "the", "skin", ",", "and", "that", "leader", "sequence", "of", "C1412930#ent", "<e1>", "is", "utilized", "preferentially", "in", "both", "tissues", "."], "h": {"id": "C0036091", "name": "C0036091#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412930", "name": "C1412930#ent", "pos": [5, 6]}}
{"token": ["The", "nucleotide", "sequence", "the", "thymidylate", "synthase", "B", "thyB", ")", "and", "C0039667#ent", "<e1>", "dfrA", ")", "gene", "regions", "from", "wild-type", "and", "trimethoprim-resistant", "(", "C1420877#ent", "<e2>", ")", "mutant", "strains", "of", "Bacillus", "subtilis", "was", "determined", "."], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420877", "name": "C1420877#ent", "pos": [21, 22]}}
{"token": ["Fentanyl", "and", "alfentanil", "have", "been", "reported", "to", "produce", "localised", "temporal", "lobe", "C0036572#ent", "<e1>", "activity", "in", "patients", "with", "C0085417#ent", "<e2>"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085417", "name": "C0085417#ent", "pos": [17, 18]}}
{"token": ["Sequence", "analysis", "that", "C1366876#ent", "<e1>", "MAPK", "could", "not", "directly", "phosphorylate", "C0812230#ent", "<e2>", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812230", "name": "C0812230#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "whereas", "in", "the", "adult", ",", "C1422277#ent", "<e1>", "neurons", "only", "contain", "C0017789#ent", "<e2>", "or", "acetylcholine", ",", "some", "neurons", "transiently", "express", "peptidergic", "phenotypes", "during", "development", "."], "h": {"id": "C1422277", "name": "C1422277#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [12, 13]}}
{"token": ["A", "51-year", "old", "woman", "treated", "with", "C0060145#ent", "<e1>", "--", "a", "new", "C0162758#ent", "<e2>", "antidepressive", "effect", "developed", "toxic", "hepatitis", "the", "treatment", "."], "h": {"id": "C0060145", "name": "C0060145#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [11, 12]}}
{"token": ["Clinical", "studies", "that", "C0026388#ent", "<e1>", "may", "be", "less", "likely", "than", "traditional", "C0040615#ent", "<e2>", "to", "induce", "tardive", "dyskinesia", "that", "C0026388#ent", "<e1>", "may", "preferentially", "ameliorate", "some", "negative", "schizophrenic", "symptoms", "."], "h": {"id": "C0026388", "name": "C0026388#ent", "pos": [3, 4]}, "relation": "has_therapeutic_class", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [11, 12]}}
{"token": ["One", "patient", "presented", "with", "an", "C0744745#ent", "<e1>", "associated", "with", "lymphocytic", "meningitis", "cerebral", "calcifications", "the", "fourth", "patient", "had", "chronic", "meningitis", "C0014544#ent", "<e2>"], "h": {"id": "C0744745", "name": "C0744745#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [19, 20]}}
{"token": ["C2986870#ent", "<e1>", "were", "cultured", "in", "Iscove", "'s", "serum-free", "medium", "C1334089#ent", "<e2>", "or", "des", "(", "1", "-", "3", ")", "C1334089#ent", "<e2>", "both", "alone", "or", "in", "combination", "with", "bFGF", "."], "h": {"id": "C2986870", "name": "C2986870#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [9, 10]}}
{"token": ["Significant", "expression", "of", "UGT1A1", "protein", "observed", "in", "all", "samples", "of", "human", "small", "intestinal", "microsomes", ",", "while", "C1421330#ent", "<e1>", "expression", "was", "undetectable", "to", "C0039070#ent", "<e2>", "and", "UGT2B7", "immunoreactivity", "was", "faint", "to", "detectable", "."], "h": {"id": "C1421330", "name": "C1421330#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0039070", "name": "C0039070#ent", "pos": [22, 23]}}
{"token": ["For", "the", "200", "mg", "dose", "group", "the", "single", "dose", "plasma", "results", "showed", "no", "significant", "differences", "in", "pharmacokinetic", "parameters", "for", "C3273837#ent", "<e1>", "and", "HO-NEF", "in", "C0014921#ent", "<e2>", "compared", "with", "PM", "subjects", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0014921", "name": "C0014921#ent", "pos": [24, 25]}}
{"token": ["Steady", "state", "pharmacokinetic", "parameters", "for", "C3273837#ent", "<e1>", "and", "HO-NEF", "in", "C0014921#ent", "<e2>", "and", "PM", "subjects", "were", "not", "significantly", "different", "."], "h": {"id": "C3273837", "name": "C3273837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014921", "name": "C0014921#ent", "pos": [10, 11]}}
{"token": ["A", "much", "more", "severe", "phenotype", "is", "seen", "in", "patients", "with", "C0950121#ent", "<e1>", "results", "from", "heterozygous", "dominant-negative", "mutations", "the", "C0017337#ent", "<e2>", "."], "h": {"id": "C0950121", "name": "C0950121#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["In", "addition", "C0271750#ent", "<e1>", "to", "be", "ruled", "out", ",", "in", "order", "to", "exclude", "C0043208#ent", "<e2>"], "h": {"id": "C0271750", "name": "C0271750#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C0043208", "name": "C0043208#ent", "pos": [13, 14]}}
{"token": ["In", "animals", ",", "these", "C0029896#ent", "<e1>", "include", ";", "scrapie", ",", "C0276640#ent", "<e2>", "chronic", "wasting", "disease", "bovine", "and", "feline", "spongiform", "encephalopathies", "and", "in", "humans", ";", "kuru", ",", "Creutzfeldt-Jakob", "disease", "CJD", ")", ",", "and", "Gerstmann-Str\u00e4ussler-Scheinker", "syndrome", "GSS", ")", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0276640", "name": "C0276640#ent", "pos": [10, 11]}}
{"token": ["Appendectomy", "has", "been", "shown", "to", "C1504686#ent", "<e1>", "against", "the", "development", "of", "C0009324#ent", "<e2>"], "h": {"id": "C1504686", "name": "C1504686#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [11, 12]}}
{"token": ["The", "existence", "of", "C0030956#ent", "<e1>", "related", "to", "mammalian", "C4049614#ent", "<e2>", "in", "the", "hypothalamo-hypophysial", "complex", "the", "trout", "suggests", "these", "neuropeptides", "may", "participate", "in", "the", "control", "of", "pituitary", "hormone", "release", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4049614", "name": "C4049614#ent", "pos": [8, 9]}}
{"token": ["By", "screening", "a", "C1335597#ent", "<e1>", "RNAi", "library", ",", "we", "identify", "the", "deubiquitinating", "enzyme", "C3273783#ent", "<e2>", "as", "a", "novel", "component", "of", "the", "Fanconi", "anemia", "pathway"], "h": {"id": "C1335597", "name": "C1335597#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273783", "name": "C3273783#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "C0356622#ent", "<e1>", "(", "PGs", ")", "on", "C0237406#ent", "<e2>", "(apo)-induced", "circling", "was", "examined", "in", "unilaterally", "lesioned", "mice", "."], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0237406", "name": "C0237406#ent", "pos": [9, 10]}}
{"token": ["The", "serum", "enzyme", "concentration", "was", "also", "increased", "in", "hypoadrenocorticism", "patients", "not", "administered", "C3540778#ent", "<e1>", ",", "suffering", "from", "concomitant", "C0238339#ent", "<e2>"], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0238339", "name": "C0238339#ent", "pos": [18, 19]}}
{"token": ["Surprisingly", ",", "E1A", ",", "which", "competes", "with", "P/CAF", "binding", "to", "C3887789#ent", "<e1>", ",", "also", "stimulated", "BSP", "transcription", "through", "NF-Y", "independently", "of", "C1623430#ent", "<e2>", ",", "C3887789#ent", "<e1>", ",", "and", "P/CAF", "."], "h": {"id": "C3887789", "name": "C3887789#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [21, 22]}}
{"token": ["This", "study", "was", "performed", "to", "determine", "whether", "premedication", "with", "acetylpromazine", "C2712370#ent", "<e1>", "the", "disposition", "kinetics", "of", "C0936073#ent", "<e2>", "in", "normal", "dogs", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0936073", "name": "C0936073#ent", "pos": [16, 17]}}
{"token": ["To", "report", "the", "cases", "of", "four", "patients", "with", "C0085293#ent", "<e1>", "experienced", "clinical", "features", "that", "are", "virtually", "identical", "to", "C0042170#ent", "<e2>", "VKH", ")", "."], "h": {"id": "C0085293", "name": "C0085293#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042170", "name": "C0042170#ent", "pos": [18, 19]}}
{"token": ["Following", "C0031179#ent", "<e1>", "injections", "in", "the", "C0001614#ent", "<e2>", "of", "both", "banks", "and", "fundus", "of", "the", "anterior", "ectosylvian", "sulcus", "retrograde", "labeling", "always", "very", "abundant", "in", "the", "ventromedial", "thalamic", "nucleus", "whichever", "part", "of", "the", "sulcus", "was", "injected", "."], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [6, 7]}}
{"token": ["We", "treated", "92", "patients", "with", "a", "C3538766#ent", "<e1>", "98", "with", "a", "C0272051#ent", "<e2>", "."], "h": {"id": "C3538766", "name": "C3538766#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0272051", "name": "C0272051#ent", "pos": [11, 12]}}
{"token": ["C0024796#ent", "<e1>", "a", "rare", "C0019247#ent", "<e2>", "connective", "tissue", "the", "surgical", "interest", "of", "which", "is", "in", "its", "propensity", "to", "the", "development", "of", "arterial", "aneurysms"], "h": {"id": "C0024796", "name": "C0024796#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [4, 5]}}
{"token": ["Of", "the", "9", "patients", "with", "C0041408#ent", "<e1>", "4", "had", "coarctation", "of", "the", "aorta", ",", "4", "C0003507#ent", "<e2>", "and", "the", "remaining", "patient", "both", "these", "lesions", "."], "h": {"id": "C0041408", "name": "C0041408#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [15, 16]}}
{"token": ["These", "agents", "will", "include", "antagonist", "and", "superagonists", ",", "peptidomimetics", ",", "recombinant", "C0030956#ent", "<e1>", "delivered", "through", "the", "baculovirus", "technology", "C4019081#ent", "<e2>", "and", "enzyme", "inhibitors"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4019081", "name": "C4019081#ent", "pos": [18, 19]}}
{"token": ["We", "list", "candidate", "C1417679#ent", "<e1>", "in", "the", "genome", "encoding", "the", "proposed", "dehydrase", "and", "C1334289#ent", "<e2>", "in", "the", "FAS-IIA", "and", "FAS-IIB", "modules", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334289", "name": "C1334289#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "Fbw7", "expression", "regulates", "the", "p53-dependent", "induction", "of", "C0017337#ent", "<e1>", "such", "as", "Lats2", "and", "p21", "in", "response", "to", "C0042671#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042671", "name": "C0042671#ent", "pos": [19, 20]}}
{"token": ["AD", "198R", "cells", "exhibited", "over-expression", "of", "the", "mdr1b", "(", "P-glycoprotein", ")", "C0017337#ent", "<e1>", ",", "cross-resistance", "to", "Adriamycin", "and", "C0042671#ent", "<e2>", ",", "and", "potentiation", "of", "drug", "cytotoxicity", "verapamil", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042671", "name": "C0042671#ent", "pos": [18, 19]}}
{"token": ["C0036205#ent", "<e1>", "a", "chronic", "inflammatory", "disorder", "unknown", "aetiology", "accompanied", "by", "a", "C1262202#ent", "<e2>"], "h": {"id": "C0036205", "name": "C0036205#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1262202", "name": "C1262202#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "we", "show", "that", "the", "Wnt-signalling", "gradient", "is", "established", "through", "a", "C1332803#ent", "<e1>", "in", "the", "posterior", "C1333570#ent", "<e2>", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333570", "name": "C1333570#ent", "pos": [18, 19]}}
{"token": ["Co-transfection", "with", "a", "catalytically", "inactive", "form", "of", "a", "MAPK", "construct", "or", "a", "dominant", "negative", "JNK", ",", "partially", "but", "significantly", "inhibited", "the", "induction", "of", "the", "C1418938#ent", "<e1>", "promoter", "by", "C1538719#ent", "<e2>", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1538719", "name": "C1538719#ent", "pos": [28, 29]}}
{"token": ["In", "contrast", ",", "9", "children", "who", "entered", "C2316810#ent", "<e1>", "lost", "an", "average", "of", "1.3", "C0037506#ent", "<e2>", "from", "the", "initial", "record", "to", "C2316810#ent", "<e1>", "(", "P=0.017", ")", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [14, 15]}}
{"token": ["In", "surviving", "C0020545#ent", "<e1>", "normotensive", "rats", "C0007785#ent", "<e2>", "induced", "hyperactivity", "and", "lesions", "of", "the", "CA1", "area", "the", "hippocampus", "."], "h": {"id": "C0020545", "name": "C0020545#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [6, 7]}}
{"token": ["Consistent", "with", "dissociation", "of", "Lck", "from", "rafts", ",", "treatment", "with", "13-OP", "abolished", "Lck", "association", "with", "the", "GPI-anchored", "protein", "C1413226#ent", "<e1>", ",", "but", "not", "the", "C1415205#ent", "<e2>"], "h": {"id": "C1413226", "name": "C1413226#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1415205", "name": "C1415205#ent", "pos": [24, 25]}}
{"token": ["In", "situ", "hybridization", "C3537453#ent", "<e1>", "in", "preantral/early", "antral", "follicles", "as", "principal", "sites", "C1413791#ent", "<e2>", "and", "LO", "mRNA", "expression", "."], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413791", "name": "C1413791#ent", "pos": [12, 13]}}
{"token": ["By", "contrast", ",", "C0020456#ent", "<e1>", "decreased", "the", "abundance", "of", "C1418372#ent", "<e2>", "mRNA", "."], "h": {"id": "C0020456", "name": "C0020456#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418372", "name": "C1418372#ent", "pos": [9, 10]}}
{"token": ["C0018213#ent", "<e1>", "characterized", "by", "the", "C0001622#ent", "<e2>", "of", "thyroid", "hormones", "to", "the", "persistent", "stimulation", "of", "TSH", "receptor", "by", "autoantibodies", "."], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [5, 6]}}
{"token": ["These", "findings", "indicate", "that", "PAF", "may", "be", "C0025517#ent", "<e1>", "in", "plasma", "by", "acetylhydrolase", "and", "then", "by", "C1744635#ent", "<e2>", "D.", "PAF", "was", "converted", "to", "phosphatidylcholine", "(", "PC", ")", "in", "washed", "rabbit", "platelets", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1744635", "name": "C1744635#ent", "pos": [16, 17]}}
{"token": ["C0060196#ent", "<e1>", "has", "properties", "similar", "to", "the", "C0541746#ent", "<e2>", "."], "h": {"id": "C0060196", "name": "C0060196#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0541746", "name": "C0541746#ent", "pos": [7, 8]}}
{"token": ["RBC", "aplasia", "has", "been", "seen", "in", "children", "receiving", "anticonvulsant", "drug", "therapy", "children", "recovering", "from", "severe", "C0162429#ent", "<e1>", "children", "with", "C0019158#ent", "<e2>", ",", "and", "in", "children", "with", "leukemia", "during", "maintenance", "therapy"], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [19, 20]}}
{"token": ["3-Phenylacetylamino-2,6-piperidinedione", "(", "A10", ")", ",", "an", "C0178472#ent", "<e1>", "has", "been", "reported", "to", "possess", "C0003392#ent", "<e2>", "certain", "neoplastic", "tissues"], "h": {"id": "C0178472", "name": "C0178472#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [13, 14]}}
{"token": ["Although", "these", "Services", "are", "gradually", "being", "upgraded", "and", "strengthened", ",", "most", "of", "their", "resources", "are", "spent", "in", "controlling", "serious", "C0003047#ent", "<e1>", "as", "foot", "and", "C0016514#ent", "<e2>", "rinderpest", "and", "Newcastle", "disease"], "h": {"id": "C0003047", "name": "C0003047#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0016514", "name": "C0016514#ent", "pos": [24, 25]}}
{"token": ["Activation", "of", "C0170168#ent", "<e1>", "its", "activator", "occurred", "also", "when", "the", "C0029007#ent", "<e2>", "conditionally", "induced", "in", "rat", "fibroblastic", "3Y1", "cells", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029007", "name": "C0029007#ent", "pos": [10, 11]}}
{"token": ["To", "determine", "the", "possible", "mechanism", "of", "poor", "bioavailability", "C1312124#ent", "<e1>", ",", "and", "clarify", "the", "respective", "contribution", "of", "C0072522#ent", "<e2>", "P-gp", ")", "and", "Cytochrome", "3A", "CYP3A", ")", "."], "h": {"id": "C1312124", "name": "C1312124#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [17, 18]}}
{"token": ["A", "patient", "with", "AIDS", "and", "C0011991#ent", "<e1>", "by", "Enterocytozoon", "bieneusi", "successfully", "treated", "with", "C0068788#ent", "<e2>", ",", "producing", "a", "complete", "clinical", "and", "parasitological", "response", ",", "while", "off", "of", "antiviral", "therapy"], "h": {"id": "C0011991", "name": "C0011991#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0068788", "name": "C0068788#ent", "pos": [13, 14]}}
{"token": ["Matrilysin", "(", "C0166059#ent", "<e1>", ")", "is", "a", "C1334706#ent", "<e2>", "that", "is", "involved", "in", "the", "degradation", "of", "extracellular", "matrix", "invasion", ",", "and", "tumor", "progression"], "h": {"id": "C0166059", "name": "C0166059#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [7, 8]}}
{"token": ["C1367482#ent", "<e1>", "is", "a", "C0003762#ent", "<e2>", "component", "of", "normal", "serum", "whose", "concentration", "can", "increase", "in", "various", "disease", "states"], "h": {"id": "C1367482", "name": "C1367482#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003762", "name": "C0003762#ent", "pos": [4, 5]}}
{"token": ["Donor", "bone", "marrow", "cells", "from", "transgenic", "mice", "constitutively", "expressing", "C0005220#ent", "<e1>", "by", "an", "endothelial-specific", "promoter", "C1705001#ent", "<e2>", ",", "were", "injected", "into", "adult", "mice", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705001", "name": "C1705001#ent", "pos": [15, 16]}}
{"token": ["These", "results", "are", "discussed", "in", "the", "context", "of", "the", "possible", "role", "of", "interferon", "in", "activation", "of", "C3813124#ent", "<e1>", "during", "the", "early", "phases", "a", "C0042769#ent", "<e2>"], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [23, 24]}}
{"token": ["Classic", "cutaneous", "manifestations", "of", "Reiter's", "syndrome", "C0022594#ent", "<e1>", "balanitis", "circinata", "both", "of", "which", "are", "microscopically", "similar", "to", "C0152081#ent", "<e2>"], "h": {"id": "C0022594", "name": "C0022594#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0152081", "name": "C0152081#ent", "pos": [17, 18]}}
{"token": ["The", "plasma", "concentration", "of", "C3888027#ent", "<e1>", "is", "markedly", "reduced", "in", "patients", "with", "C0022661#ent", "<e2>", "as", "compared", "with", "healthy", "subjects"], "h": {"id": "C3888027", "name": "C3888027#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [12, 13]}}
{"token": ["Reduced", "binding", "between", "C1422163#ent", "<e1>", "and", "beta-catenin", "is", "observed", "after", "C3899164#ent", "<e2>", "overexpression", "and", "cellular", "oxidative", "stress", "which", "simultaneously", "increases", "binding", "between", "beta-catenin", "and", "C3899164#ent", "<e2>", "."], "h": {"id": "C1422163", "name": "C1422163#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3899164", "name": "C3899164#ent", "pos": [10, 11]}}
{"token": ["Such", "polysaccharides", "are", "either", "C0178695#ent", "<e1>", "synthesized", "by", "virus-encoded", "hyaluronan", "synthase", "HAS", ")", "or", "C0008145#ent", "<e2>", "synthesized", "by", "viral", "chitin", "synthase", "CHS", ")", "."], "h": {"id": "C0178695", "name": "C0178695#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008145", "name": "C0008145#ent", "pos": [14, 15]}}
{"token": ["C1860596#ent", "<e1>", "TD", ")", "is", "a", "C0007302#ent", "<e2>", "poultry", "the", "natural", "etiology", "which", "is", "not", "known", "."], "h": {"id": "C1860596", "name": "C1860596#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007302", "name": "C0007302#ent", "pos": [6, 7]}}
{"token": ["IDO", "inhibits", "eosinophilic", "inflammation", "in", "a", "murine", "asthma", "model", "but", "little", "is", "known", "about", "its", "role", "in", "C0004096#ent", "<e1>", "patients", "or", "the", "effects", "of", "C3540727#ent", "<e2>", "on", "this", "key", "regulatory", "enzyme"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3540727", "name": "C3540727#ent", "pos": [24, 25]}}
{"token": ["In", "Escherichia", "coli", "exonuclease", "I", "C1707870#ent", "<e1>", ")", "is", "a", "C0950448#ent", "<e2>", "degrades", "single-stranded", "DNA"], "h": {"id": "C1707870", "name": "C1707870#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0950448", "name": "C0950448#ent", "pos": [10, 11]}}
{"token": ["About", "15", "%", "of", "the", "population", "have", "C0026946#ent", "<e1>", "the", "feet", "(", "C0040259#ent", "<e2>", "athlete's", "foot", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [12, 13]}}
{"token": ["The", "mass", "of", "the", "fragment", "is", "consistent", "with", "12-mer", "C-terminal", "amino", "acid", "fragment", "from", "proteolysis", "by", "C0041236#ent", "<e1>", "with", "both", "cysteine", "residues", "modified", "by", "C0138843#ent", "<e2>"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0138843", "name": "C0138843#ent", "pos": [24, 25]}}
{"token": ["These", "results", "showed", "that", "AhR", ",", "C1567723#ent", "<e1>", ",", "GSTP1", "and", "GSTT1", "polymorphisms", "were", "associated", "with", "urinary", "C0069717#ent", "<e2>", "concentrations", "in", "Chinese", "coke", "oven", "workers"], "h": {"id": "C1567723", "name": "C1567723#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0069717", "name": "C0069717#ent", "pos": [17, 18]}}
{"token": ["C3710848#ent", "<e1>", "is", "required", "for", "the", "trypsinolysis", "of", "pig", "C0008855#ent", "<e2>", "and", "at", "relatively", "high", "concentrations", "of", "this", "compound", "trypsinolysis", "of", "one", "subunit", "leaves", "other", "subunit", "fully", "active", "."], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008855", "name": "C0008855#ent", "pos": [9, 10]}}
{"token": ["To", "identify", "the", "germline", "counterpart", "of", "C1419009#ent", "<e1>", ",", "genomic", "DNA", "the", "same", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "patient", "from", "whom", "C1419009#ent", "<e1>", "was", "derived", "was", "used", "in", "the", "polymerase", "chain", "reaction", "PCR", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419009", "name": "C1419009#ent", "pos": [6, 7]}}
{"token": ["Patients", "with", "C0600260#ent", "<e1>", "COPD", ")", "and/or", "central", "sleep", "apnea", "sometimes", "treated", "with", "C0007036#ent", "<e2>", "to", "improve", "blood", "gas", "values", "."], "h": {"id": "C0600260", "name": "C0600260#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007036", "name": "C0007036#ent", "pos": [13, 14]}}
{"token": ["The", "inhibition", "seems", "to", "be", "a", "consequence", "of", "the", "occupation", "by", "C3539689#ent", "<e1>", "of", "a", "site", "overlapping", "a", "C0031716#ent", "<e2>", "bv-PLA2", "presumably", "involved", "in", "the", "interface", "desolvation", "process", "."], "h": {"id": "C3539689", "name": "C3539689#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031716", "name": "C0031716#ent", "pos": [18, 19]}}
{"token": ["Human", "T-cell", "lymphotropic", "virus", "type", "I", "HTLV-I", ")", "is", "known", "to", "be", "associated", "with", "non-neoplastic", "inflammatory", "disorders", "as", "C0030481#ent", "<e1>", "arthropathy", ",", "uveitis", "and", "C0024205#ent", "<e2>", ",", "in", "addition", "to", "neoplastic", "adult", "T-cell", "leukemia/lymphoma", "ATLL", ")", "."], "h": {"id": "C0030481", "name": "C0030481#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0024205", "name": "C0024205#ent", "pos": [24, 25]}}
{"token": ["On", "the", "basis", "of", "their", "pharmacodynamic", "profiles", "the", "newer", "C0949665#ent", "<e1>", ",", "including", "such", "C1875319#ent", "<e2>", "gatifloxacin", ",", "should", "produce", "satisfactory", "clinical", "and", "microbiological", "outcomes", "against", "pathogens", "commonly", "associated", "with", "community-acquired", "respiratory-tract", "infections"], "h": {"id": "C0949665", "name": "C0949665#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1875319", "name": "C1875319#ent", "pos": [14, 15]}}
{"token": ["An", "increase", "in", "depressive", "symptomatology", "is", "seen", "in", "women", "with", "C0758818#ent", "<e1>", "as", "well", "as", "in", "ante", "C1364508#ent", "<e2>", "Ab+ve", "women", "without", "C0758818#ent", "<e1>", "."], "h": {"id": "C0758818", "name": "C0758818#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1364508", "name": "C1364508#ent", "pos": [17, 18]}}
{"token": ["The", "patients", "were", "divided", "into", "3", "groups", ":", "127", "cases", "of", "C0238074#ent", "<e1>", "47", "cases", "of", "glomerulonephritis", "and", "17", "cases", "of", "C0010068#ent", "<e2>"], "h": {"id": "C0238074", "name": "C0238074#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [21, 22]}}
{"token": ["C0151317#ent", "<e1>", "Mycobacterium", "avium", "subspecies", "paratuberculosis", "M.", "paratuberculosis", "has", "been", "proposed", "as", "a", "cause", "of", "C0010346#ent", "<e2>"], "h": {"id": "C0151317", "name": "C0151317#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [15, 16]}}
{"token": ["A", "range", "of", "biochemical", "and", "molecular", "studies", "identified", "potential", "components", "of", "G-protein", "signalling", "plants", ",", "most", "notably", "a", "C1334043#ent", "<e1>", "of", "the", "G-protein", "coupled", "receptor", "superfamily", "C1417217#ent", "<e2>", ")", "and", "the", "G", "alpha", "G", "beta", "subunits", "heterotrimeric", "G-proteins"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417217", "name": "C1417217#ent", "pos": [26, 27]}}
{"token": ["When", "either", "2", "micrograms/ml", "C3536807#ent", "<e1>", "D", "or", "20", "micrograms/ml", "cycloheximide", "was", "added", "simultaneously", "with", "C0078956#ent", "<e2>", "to", "the", "culture", ",", "the", "repressive", "effect", "of", "C0078956#ent", "<e2>", "on", "CD30", "was", "abolished", "."], "h": {"id": "C3536807", "name": "C3536807#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [15, 16]}}
{"token": ["It", "is", "probable", "that", "the", "C3274826#ent", "<e1>", "induce", "a", "B(1)", "C0376286#ent", "<e2>", "which", "causes", "the", "characteristic", "pathology", "and", "the", "resultant", "symptoms", "."], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0376286", "name": "C0376286#ent", "pos": [10, 11]}}
{"token": ["Immunoreactive", "C1332803#ent", "<e1>", "was", "demonstrated", "at", "the", "cell", "membrane", "glandular", "cells", "the", "C1709246#ent", "<e2>", "non-FAP", "carcinomas", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1709246", "name": "C1709246#ent", "pos": [12, 13]}}
{"token": ["C1332803#ent", "<e1>", "showed", "reduced", "membrane", "staining", "with", "C1709246#ent", "<e2>"], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1709246", "name": "C1709246#ent", "pos": [7, 8]}}
{"token": ["C1412277#ent", "<e1>", "glycoforms", "contribute", "to", "the", "molecular", "heterogeneity", "the", "perineuronal", "C1423506#ent", "<e2>", "."], "h": {"id": "C1412277", "name": "C1412277#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423506", "name": "C1423506#ent", "pos": [10, 11]}}
{"token": ["This", "latter", "event", "suggests", "that", "besides", "degradation", "of", "phosphatidylinositol", "4,5-bisphosphates", "by", "C0031669#ent", "<e1>", "some", "phosphatidylinositol", "4-phosphates", "have", "been", "degraded", "through", "the", "C0001109#ent", "<e2>"], "h": {"id": "C0031669", "name": "C0031669#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001109", "name": "C0001109#ent", "pos": [21, 22]}}
{"token": ["C0009014#ent", "<e1>", "can", "be", "used", "in", "patients", "with", "C0035086#ent", "<e2>", "does", "not", "cause", "worsening", "of", "renal", "function"], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035086", "name": "C0035086#ent", "pos": [8, 9]}}
{"token": ["In", "eczema", ",", "both", "lymphocytes", "and", "C0064833#ent", "<e1>", "a", "decreased", "C0178503#ent", "<e2>"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0178503", "name": "C0178503#ent", "pos": [10, 11]}}
{"token": ["As", "an", "association", "between", "C0795849#ent", "<e1>", "HSCR/WS", "has", "been", "reported", "previously", ",", "these", "data", "suggest", "that", "there", "is", "a", "gene", "on", "C0795849#ent", "<e1>", "is", "responsible", "for", "C1414382#ent", "<e1>", "or", "HSCR", "or", "both", "."], "h": {"id": "C0795849", "name": "C0795849#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414382", "name": "C1414382#ent", "pos": [26, 27]}}
{"token": ["The", "binding", "of", "BCP", "to", "bovine", "serum", "albumin", "was", "slightly", "inhibited", "by", "C1426677#ent", "<e1>", ",", "but", "not", "by", "C1412690#ent", "<e2>", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412690", "name": "C1412690#ent", "pos": [18, 19]}}
{"token": ["C1615557#ent", "<e1>", "binds", "to", "T", "cell-surface", "glycoproteins", "C1335285#ent", "<e2>", ",", "CD43", ",", "and", "CD7", ",", "although", "the", "precise", "roles", "of", "each", "receptor", "in", "cell", "death", "unknown", "."], "h": {"id": "C1615557", "name": "C1615557#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335285", "name": "C1335285#ent", "pos": [7, 8]}}
{"token": ["C0009014#ent", "<e1>", "and", "B-HT", "920", "were", "also", "ineffective", ",", "but", "C0877830#ent", "<e2>", "elevated", "the", "seizure", "threshold", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0877830", "name": "C0877830#ent", "pos": [10, 11]}}
{"token": ["The", "treatment", "was", "well", "tolerated", ",", "cured", "the", "C0002871#ent", "<e1>", ",", "removed", "the", "obstruction", "and", "ended", "C0030193#ent", "<e2>", "stool", "evacuation", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [16, 17]}}
{"token": ["The", "C0079405#ent", "<e1>", "the", "first", "C0086903#ent", "<e2>", "HIV-1", "to", "be", "found", "in", "the", "virus", "particle"], "h": {"id": "C0079405", "name": "C0079405#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [5, 6]}}
{"token": ["It", "has", "been", "reported", "that", "theophylline", "was", "metabolized", "to", "1,3-dimethyluric", "acid", "C1620185#ent", "<e1>", "and", "CYP2E1", "and", "C0006644#ent", "<e2>", "via", "C1620185#ent", "<e1>", ",", "which", "was", "metabolized", "further", "to", "1-methyluric", "acid", "xanthine", "oxidase", "rats", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [11, 12]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0006644", "name": "C0006644#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "incubation", "of", "activated", "macrophages", "with", "C0751039#ent", "<e1>", "and", "FK506", "contributed", "to", "maintain", "higher", "levels", "of", "C1704467#ent", "<e2>", "than", "in", "LPS/IFN-gamma", "treated", "cells"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [17, 18]}}
{"token": ["After", "4", "weeks", "of", "C0038317#ent", "<e1>", "treatment", ",", "plasma", "sTNFR1", "and", "C1363982#ent", "<e2>", "levels", "returned", "to", "normal", "in", "both", "patients", "with", "SRNS", "and", "SSNS", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1363982", "name": "C1363982#ent", "pos": [11, 12]}}
{"token": ["C0008286#ent", "<e1>", "(", "CPZ", ")", "and", "three", "other", "C0031436#ent", "<e2>", "and", "the", "structurally", "related", "antidepressant", "drugs", "imipramine", "and", "amitriptyline", "were", "found", "to", "depress", "human", "neutrophil", "chemotactic", "responsiveness"], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0031436", "name": "C0031436#ent", "pos": [8, 9]}}
{"token": ["Instead", ",", "C0057856#ent", "<e1>", "induces", "ubiquitylation", "of", "the", "C1334899#ent", "<e2>", "degradation", "through", "the", "proteasome", "."], "h": {"id": "C0057856", "name": "C0057856#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334899", "name": "C1334899#ent", "pos": [8, 9]}}
{"token": ["Citrin", "deficiency", "by", "SLC25A13", "gene", "develops", "into", "C1863844#ent", "<e1>", "CTLN2", ")", "and", "may", "be", "accompanied", "with", "C2711227#ent", "<e2>", "steatohepatitis", "."], "h": {"id": "C1863844", "name": "C1863844#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "show", "that", "C1420808#ent", "<e1>", "-", "1", ",", "a", "mutant", "form", "of", "C1420808#ent", "<e1>", "that", "mislocalizes", "to", "the", "plasma", "membrane", "requires", "the", "C1419420#ent", "<e1>", "plasma", "membrane", "metalloreductase", "for", "Cu(I", ")", "import", "."], "h": {"id": "C1420808", "name": "C1420808#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419420", "name": "C1419420#ent", "pos": [23, 24]}}
{"token": ["IL-2R", "(", "C1419030#ent", "<e1>", ")", ",", "on", "several", "T-cell", "lines", "by", "human", "T-lymphotropic", "virus-I", "C0079556#ent", "<e2>", ")", ",", "as", "well", "as", "several", "subclones", "of", "the", "natural", "killer", "(NK)-like", "cell", "line", "YT"], "h": {"id": "C1419030", "name": "C1419030#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079556", "name": "C0079556#ent", "pos": [14, 15]}}
{"token": ["Insulin-stimulated", "activation", "of", "insulin", "receptors", "downstream", "molecules", ",", "such", "as", "C1704984#ent", "<e1>", "and", "Akt", ",", "was", "attenuated", "in", "the", "skeletal", "muscles", "C1413146#ent", "<e2>", "null", "mice", "but", "not", "in", "the", "liver", ",", "without", "affecting", "protein", "expression", "subcellular", "localization"], "h": {"id": "C1704984", "name": "C1704984#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413146", "name": "C1413146#ent", "pos": [21, 22]}}
{"token": ["C0051949#ent", "<e1>", "ApA", ")", "and", "B", "(", "C1868120#ent", "<e2>", ")", "are", "49-amino", "acid", "polypeptide", "toxins", "from", "the", "Pacific", "sea", "anemone", "Anthopleura", "xanthogrammica", "interfere", "with", "inactivation", "of", "voltage-gated", "sodium", "channels"], "h": {"id": "C0051949", "name": "C0051949#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1868120", "name": "C1868120#ent", "pos": [7, 8]}}
{"token": ["Forty", "patients", "with", "C0003873#ent", "<e1>", "given", "either", "one", "intramuscular", "injection", "of", "100", "mg", "C0022635#ent", "<e2>", "with", "two", "placebo", "capsules", "or", "one", "intramuscular", "injection", "of", "placebo", "with", "two", "50", "mg", "C0022635#ent", "<e2>", "capsules", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0022635", "name": "C0022635#ent", "pos": [13, 14]}}
{"token": ["Sensitization", "was", "blocked", "by", "pertussis", "toxin", "C2936804#ent", "<e1>", "haloperidol", ",", "butaclamol", ",", "and", "C0009079#ent", "<e2>", ",", "indicating", "inverse", "agonist", "activity", "these", "compounds", "at", "D2T344", "K", "."], "h": {"id": "C2936804", "name": "C2936804#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [13, 14]}}
{"token": ["of", "C2936804#ent", "<e1>", "haloperidol", "and", "C0009079#ent", "<e2>", ",", "had", "a", "potentiating", "effect", "on", "acupuncture", "analgesia"], "h": {"id": "C2936804", "name": "C2936804#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [5, 6]}}
{"token": ["We", "have", "used", "these", "antisera", "in", "confocal", "laser", "scanning", "immunofluorescence", "microscopy", "localise", "the", "intracellular", "location", "of", "potentially", "amyloidogenic", "beta", "C1364818#ent", "<e1>", "processing", "fragments", "such", "as", "C3470427#ent", "<e2>", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3470427", "name": "C3470427#ent", "pos": [25, 26]}}
{"token": ["When", "transfected", "into", "Y-1", "cells", ",", "reporter", "gene", "was", "increased", "following", "treatment", "with", "ACTH", "or", "C0917964#ent", "<e1>", ",", "but", "not", "with", "Ang", "II", "the", "C0006683#ent", "<e2>", "BAYK8644", ",", "or", "ionomycin", "."], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0006683", "name": "C0006683#ent", "pos": [24, 25]}}
{"token": ["Insulin-like", "growth", "factor", "binding", "protein-3", "C0123707#ent", "<e1>", ")", "and", "the", "transforming", "growth", "factor-beta", "TGF-beta", ")", "gene", "family", "C1420369#ent", "<e2>", "-", "3", ")", "were", "examined", "as", "potential", "components", "of", "the", "retinoid", "signaling", "pathway", "normal", "human", "bronchial", "epithelial", "cells", "."], "h": {"id": "C0123707", "name": "C0123707#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "the", "effectiveness", "of", "the", "Welsh", "general", "surgery", "(", "hernia", "and", "C0042345#ent", "<e1>", "treatment", "centre", "as", "part", "of", "the", "C0796085#ent", "<e2>", "reforms", ",", "in", "terms", "of", "its", "impact", "upon", "throughput", "and", "waiting", "lists"], "h": {"id": "C0042345", "name": "C0042345#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0796085", "name": "C0796085#ent", "pos": [20, 21]}}
{"token": ["However", ",", "while", "C0752124#ent", "<e1>", "develops", "as", "a", "late-onset", ",", "progressive", "C0007758#ent", "<e2>", ",", "EA2", "has", "an", "earlier", ",", "and", "episodic", ",", "onset", "."], "h": {"id": "C0752124", "name": "C0752124#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [11, 12]}}
{"token": ["Coal", "Tar", "monographed", "by", "the", "FDA", "as", "Category", "I", "safe", "and", "effective", ")", "C0013231#ent", "<e1>", "drug", "ingredient", "use", "in", "the", "treatment", "of", "dandruff", ",", "C0221244#ent", "<e2>", ",", "and", "psoriasis", "."], "h": {"id": "C0013231", "name": "C0013231#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0221244", "name": "C0221244#ent", "pos": [24, 25]}}
{"token": ["Coal", "Tar", "monographed", "by", "the", "FDA", "as", "Category", "I", "safe", "and", "effective", ")", "C0013231#ent", "<e1>", "drug", "ingredient", "use", "in", "the", "treatment", "of", "C0221244#ent", "<e2>", ",", "seborrhoea", ",", "and", "psoriasis", "."], "h": {"id": "C0013231", "name": "C0013231#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0221244", "name": "C0221244#ent", "pos": [22, 23]}}
{"token": ["Therefore", ",", "the", "effect", "of", "thalidomide", "and", "a", "C3265467#ent", "<e1>", "cc-1069", ")", "on", "the", "proliferation", "in", "vitro", "C0669365#ent", "<e2>", "and", "glioma", "cells", "tested", "."], "h": {"id": "C3265467", "name": "C3265467#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}}
{"token": ["C2717971#ent", "<e1>", "as", "thrombin", ",", "C0147080#ent", "<e2>", "trypsin", ",", "or", "cathepsin", "G", "for", "example", ",", "are", "highly", "active", "mediators", "diverse", "biological", "activities"], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0147080", "name": "C0147080#ent", "pos": [5, 6]}}
{"token": ["DNA", "sequencing", "shown", "these", "sequences", "to", "be", "99", "%", "C1334043#ent", "<e1>", "to", "the", "BR6", "strain", "of", "C1710651#ent", "<e2>", "and", "100", "%", "homologous", "to", "the", "GR", "and", "C3H", "strains", "C1710651#ent", "<e2>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1710651", "name": "C1710651#ent", "pos": [16, 17]}}
{"token": ["The", "indications", "for", "surgical", "treatment", "C1291077#ent", "<e1>", "associated", "with", "pain", "or", "C0013395#ent", "<e2>", "."], "h": {"id": "C1291077", "name": "C1291077#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [11, 12]}}
{"token": ["Congenital", "amegakaryocytic", "thrombocytopenia", "CAMT", ")", "is", "a", "rare", "C3808553#ent", "<e1>", "associated", "with", "thrombocytopenia", "and", "a", "tendency", "to", "progress", "to", "C0002874#ent", "<e2>"], "h": {"id": "C3808553", "name": "C3808553#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0002874", "name": "C0002874#ent", "pos": [19, 20]}}
{"token": ["Rac", "and", "Cdc42", ",", "but", "not", "C0525678#ent", "<e1>", "or", "Rho", ",", "were", "responsible", "for", "this", "C1334474#ent", "<e2>"], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [15, 16]}}
{"token": ["ET-1", ",", "through", "ET(A", ")", "receptors", ",", "evoked", "activation", "of", "C0525678#ent", "<e1>", "and", "subsequent", "phosphorylation", "of", "Raf-1", ",", "mitogen-activated", "protein", "kinase", "kinase", "C1334474#ent", "<e2>", "and", "ERK", "1/2", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [22, 23]}}
{"token": ["Coexpressing", "constitutively", "active", "forms", "C0525678#ent", "<e1>", ",", "Raf", ",", "or", "C1334474#ent", "<e2>", "MEK1", ")", "increased", "promoter", "activity", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [10, 11]}}
{"token": ["In", "C1881236#ent", "<e1>", "infiltrating", "cells", "the", "monocyte/macrophage", "system", "the", "major", "site", "of", "C0040060#ent", "<e2>"], "h": {"id": "C1881236", "name": "C1881236#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0040060", "name": "C0040060#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "C2917660#ent", "<e1>", "substitutions", "in", "the", "nine", "residue", "plasminogen-binding", "motif", "C0031691#ent", "<e2>", "significantly", "reduced", "degradation", "of", "ECM", "or", "Matrigel", "by", "mutated", "pneumococci", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031691", "name": "C0031691#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "C1414437#ent", "<e1>", "also", "led", "to", "an", "increase", "in", "tyrosine", "phosphorylation", "C1705831#ent", "<e2>", "and", "SLP-76", ",", "two", "key", "proteins", "in", "T-cell", "receptor", "TCR", ")", "signalling", "."], "h": {"id": "C1414437", "name": "C1414437#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705831", "name": "C1705831#ent", "pos": [12, 13]}}
{"token": ["C0235025#ent", "<e1>", "an", "uncommon", "complication", "of", "C0398650#ent", "<e2>", "ITP", ")", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0398650", "name": "C0398650#ent", "pos": [6, 7]}}
{"token": ["In", "the", "C4055377#ent", "<e1>", "considered", "to", "be", "responsible", "or", "jointly", "responsible", "for", "post", "C1419380#ent", "<e2>", "incontinence", "in", "a", "rate", "as", "high", "as", "93", "%", "."], "h": {"id": "C4055377", "name": "C4055377#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419380", "name": "C1419380#ent", "pos": [13, 14]}}
{"token": ["These", "times", "are", "consistent", "with", "distances", "of", "the", "genes", "from", "the", "C0035681#ent", "<e1>", "site", "in", "the", "C0022895#ent", "<e2>", "."], "h": {"id": "C0035681", "name": "C0035681#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022895", "name": "C0022895#ent", "pos": [16, 17]}}
{"token": ["Neurological", "symptoms", "in", "association", "with", "increased", "carbamazepine", "levels", "because", "of", "a", "probable", "drug", "interaction", "C0000598#ent", "<e1>", "and", "carbamazepine", "in", "an", "C0014544#ent", "<e2>", "patient", "undergoing", "coronary", "stenting"], "h": {"id": "C0000598", "name": "C0000598#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [20, 21]}}
{"token": ["Clinical", "chelation", "therapy", "mercury", "poisoning", "uses", "one", "or", "both", "of", "two", "drugs", "--", "meso-dimercaptosuccinic", "acid", "DMSA", ")", "and", "C0041738#ent", "<e1>", "DMPS", ")", ",", "commercially", "sold", "as", "C0719256#ent", "<e2>", "and", "Dimaval", ",", "respectively", "."], "h": {"id": "C0041738", "name": "C0041738#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0719256", "name": "C0719256#ent", "pos": [26, 27]}}
{"token": ["The", "interactions", "of", "three", "neuroleptic", "drugs", "C0009079#ent", "<e1>", "(", "CLZ", ")", ",", "chlorpromazine", "(", "C1413693#ent", "<e2>", ")", ",", "and", "haloperidol", "(", "HPD", ")", "with", "phospholipids", "were", "compared", "using", "DSC", "and", "Langmuir", "balance", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413693", "name": "C1413693#ent", "pos": [14, 15]}}
{"token": ["We", "reported", "previously", "that", "OX40", ",", "a", "member", "of", "the", "tumor", "necrosis", "factor", "receptor", "family", "is", "expressed", "C0669365#ent", "<e1>", "on", "fresh", "C1422004#ent", "<e2>", "isolated", "from", "patients", "with", "adult", "T-cell", "leukemia", "ATL", ")", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1422004", "name": "C1422004#ent", "pos": [21, 22]}}
{"token": ["Mono-specific", "antibodies", "against", "isoenzymes", "of", "C0034348#ent", "<e1>", "chicken", "and", "the", "C0031179#ent", "<e2>", "used", "."], "h": {"id": "C0034348", "name": "C0034348#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031179", "name": "C0031179#ent", "pos": [10, 11]}}
{"token": ["Among", "synthesized", "cyclic", "pentapeptides", "compound", "36", "C0763382#ent", "<e1>", ")", "was", "the", "most", "potent", "ETA", "receptor", "antagonist", "with", "a", "C1839576#ent", "<e2>", "of", "8.1", "against", "ET-1-induced", "vasoconstriction", "in", "isolated", "porcine", "coronary", "arteries"], "h": {"id": "C0763382", "name": "C0763382#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [18, 19]}}
{"token": ["Fluorene", "serves", "as", "sole", "C0524928#ent", "<e1>", "and", "energy", "source", "the", "strain", "LB126", "and", "phenanthrene", "and", "C0060514#ent", "<e2>", "are", "cometabolically", "degraded", "by", "this", "species", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060514", "name": "C0060514#ent", "pos": [15, 16]}}
{"token": ["Plasmid", "C1332791#ent", "<e1>", "also", "augmented", "the", "immune", "response", "by", "DNA", "vaccines", "expressing", "HIV-1", "C0017346#ent", "<e2>", "and", "Nef-Tat-Vif", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [13, 14]}}
{"token": ["These", "genes", "include", "many", "not", "recognized", "previously", "as", "differentially", "expressed", "in", "prostate", "cancer", "BPH", ",", "including", "C0062539#ent", "<e1>", ",", "which", "codes", "for", "a", "C1420785#ent", "<e2>"], "h": {"id": "C0062539", "name": "C0062539#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420785", "name": "C1420785#ent", "pos": [23, 24]}}
{"token": ["The", "surface-bound", "protein", "can", "be", "chased", "to", "the", "C0021699#ent", "<e1>", "the", "addition", "of", "C2744579#ent", "<e2>", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "cation", "occlusion", "sites", "and", "the", "transport", "pathway", "C0021699#ent", "<e1>", "quite", "separate", "from", "the", "C2744579#ent", "<e2>", "binding", "site", "located", "on", "the", "cytoplasmic", "domain", "the", "alpha", "chain"], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [10, 11]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [16, 17]}}
{"token": ["In", "vitro", "C0054869#ent", "<e1>", "an", "autocrine", "C0026249#ent", "<e2>", "on", "breast", "cancer", "cells", "can", "be", "auto-activated", "to", "degrade", "extracellular", "matrix", "proteoglycans", "in", "acidic", "microenvironment"], "h": {"id": "C0054869", "name": "C0054869#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [6, 7]}}
{"token": ["Although", "C0341353#ent", "<e1>", "in", "10", "%", "of", "patients", "with", "C0003615#ent", "<e2>", "its", "surgical", "management", "surrounded", "with", "controversy", "."], "h": {"id": "C0341353", "name": "C0341353#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003615", "name": "C0003615#ent", "pos": [9, 10]}}
{"token": ["C0162628#ent", "<e1>", "trigger", "the", "autoimmune", "assault", "leading", "to", "C0011854#ent", "<e2>"], "h": {"id": "C0162628", "name": "C0162628#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [8, 9]}}
{"token": ["As", "for", "other", "C0014548#ent", "<e1>", "gabapentin", "may", "precipitate", "myoclonic", "status", "in", "a", "C0270736#ent", "<e2>", "such", "as", "BAFME", ",", "as", "is", "reported", "herein", "for", "the", "first", "time", "."], "h": {"id": "C0014548", "name": "C0014548#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0270736", "name": "C0270736#ent", "pos": [12, 13]}}
{"token": ["C0018939#ent", "<e1>", "which", "involvement", "of", "the", "C1425360#ent", "<e2>", "commonly", "occurs", "but", "is", "relatively", "nonspecific", "and", "not", "diagnostic", "include", "dermatitis", ",", "lichen", "striatus", "parakeratosis", "pustulosa", "pityriasis", "rubra", "pilaris", "acrokeratosis", "paraneoplastica", "pemphigus", "vulgaris", "epidermolysis", "bullosa", "porokeratosis", "of", "Mibelli", ",", "and", "acanthosis", "nigricans"], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1425360", "name": "C1425360#ent", "pos": [6, 7]}}
{"token": ["The", "phenotype", "of", "C3889135#ent", "<e1>", "null", "mice", "characterized", "by", "C0020443#ent", "<e2>", ",", "impaired", "secretion", "of", "bile", "acids", "failure", "to", "thrive", "."], "h": {"id": "C3889135", "name": "C3889135#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020443", "name": "C0020443#ent", "pos": [9, 10]}}
{"token": ["Adrenaline", "and", "db-cAMP", "increased", "glycogen", "synthase", "kinase", "Ser(9", ")", "phosphorylation", "independently", "of", "C1705328#ent", "<e1>", "activation", "and", "enhanced", "C4082284#ent", "<e2>", "GSK-3beta", "Ser(9", ")", "phosphorylation", "."], "h": {"id": "C1705328", "name": "C1705328#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [17, 18]}}
{"token": ["Mitogen-activated", "protein", "kinase", "MAPK", ")", "C1956003#ent", "<e1>", "(", "MKP-1", ")", "is", "a", "C0287531#ent", "<e2>", "is", "involved", "in", "the", "regulation", "of", "cell", "survival", "differentiation", "and", "apoptosis", "through", "inactivating", "MAPKs", "by", "dephosphorylation", "."], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0287531", "name": "C0287531#ent", "pos": [12, 13]}}
{"token": ["Coupling", "factor", "6", "CF6", ")", ",", "a", "component", "of", "adenosine", "triphosphate", "ATP", ")", "synthase", ",", "is", "circulating", "and", "functions", "as", "an", "endogenous", "C4255305#ent", "<e1>", "by", "inhibiting", "C1333201#ent", "<e2>"], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1333201", "name": "C1333201#ent", "pos": [26, 27]}}
{"token": ["The", "mechanism", "of", "apoptosis", "induced", "by", "C1423062#ent", "<e1>", "deacetylase", "inhibitors", "both", "human", "breast", "cancer", "MCF-7", "and", "MCF-7", "C0376622#ent", "<e2>", "studied", "."], "h": {"id": "C1423062", "name": "C1423062#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0376622", "name": "C0376622#ent", "pos": [17, 18]}}
{"token": ["Nevertheless", ",", "the", "vessels", "of", "the", "C0024591#ent", "<e1>", "were", "positive", "for", "CD34", ",", "CD31", ",", "and", "C1336938#ent", "<e2>"], "h": {"id": "C0024591", "name": "C0024591#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [16, 17]}}
{"token": ["Benign", "C0030804#ent", "<e1>", "a", "rare", "C0021390#ent", "<e2>", "affecting", "the", "upper", "aero-digestive", "tract", "conjunctivae", "."], "h": {"id": "C0030804", "name": "C0030804#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [5, 6]}}
{"token": ["Low", "doses", "ritonavir", ",", "a", "strong", "inhibitor", "of", "C1142644#ent", "<e1>", "enhances", "the", "pharmacokinetic", "profile", "of", "C0700483#ent", "<e2>", "with", "increased", "serum", "levels"], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [8, 9]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0700483", "name": "C0700483#ent", "pos": [15, 16]}}
{"token": ["The", "dopamine", "agonist", "C0006230#ent", "<e1>", "has", "been", "widely", "used", "to", "facilitate", "pregnancy", "in", "C0020514#ent", "<e2>", "women", ",", "with", "a", "success", "rate", "80", "%", "in", "relevant", "cases", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020514", "name": "C0020514#ent", "pos": [13, 14]}}
{"token": ["The", "phylogenetic", "results", "indicate", "that", "the", "Alrp", "sequences", "S.", "cerevisiae", "a", "common", "carboxy-terminus", "with", "C0086376#ent", "<e1>", "related", "to", "C3541396#ent", "<e2>", "efflux", "transport"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3541396", "name": "C3541396#ent", "pos": [18, 19]}}
{"token": ["Beta2-adrenergic", "receptor", "beta2AR", ")", "C0243192#ent", "<e1>", "acutely", "relieve", "bronchoconstriction", "via", "cAMP-mediated", "relaxation", "of", "airway", "smooth", "muscle", "C0599122#ent", "<e2>", ")", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599122", "name": "C0599122#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "assess", "circadian", "Prl", "pattern", "in", "children", "with", "growth", "hormone", "deficiency", "C0271561#ent", "<e1>", ")", "and", "congenital", "organic", "disorders", "the", "hypothalamic-pituitary", "region", "C1337105#ent", "<e2>", ")", "."], "h": {"id": "C0271561", "name": "C0271561#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1337105", "name": "C1337105#ent", "pos": [27, 28]}}
{"token": ["C3180890#ent", "<e1>", "shows", "no", "significant", "inhibition", "of", "human", "C0017824#ent", "<e2>", "Ki", ">", "10", "mM", ")", "and", "thus", "provides", "a", "novel", "selective", "drug", "lead", "."], "h": {"id": "C3180890", "name": "C3180890#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017824", "name": "C0017824#ent", "pos": [8, 9]}}
{"token": ["Mutations", "in", "some", "components", "of", "TFIIH", "are", "associated", "with", "hereditary", "human", "syndromes", "xeroderma", "pigmentosum", "XP", ")", ",", "C0009207#ent", "<e1>", "CS", ")", "and", "trichothiodystrophy", "(", "C1705972#ent", "<e2>", ")", "."], "h": {"id": "C0009207", "name": "C0009207#ent", "pos": [17, 18]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705972", "name": "C1705972#ent", "pos": [24, 25]}}
{"token": ["A", "single", ",", "intraperitoneal", "injection", "of", "C0086154#ent", "<e1>", "(", "DDTC", ")", "to", "adult", ",", "male", "Sprague-Dawley", "rats", "decreased", "C0051169#ent", "<e2>", "P-450", ")", "concentrations", "."], "h": {"id": "C0086154", "name": "C0086154#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [18, 19]}}
{"token": ["Carbamazepine", "is", "an", "important", "C1254351#ent", "<e1>", "used", "in", "the", "management", "of", "seizures", ",", "trigeminal", "neuralgia", "and", "C0006109#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006109", "name": "C0006109#ent", "pos": [16, 17]}}
{"token": ["However", ",", "platelet", "activation", ",", "and", "desensitization", "to", "AA", "and", "C0917834#ent", "<e1>", ",", "was", "prevented", "by", "C0040846#ent", "<e2>", "and", "compound", "L636499", ",", "two", "thromboxane/endoperoxide", "receptor", "antagonists", "."], "h": {"id": "C0917834", "name": "C0917834#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040846", "name": "C0040846#ent", "pos": [16, 17]}}
{"token": ["Chronic", "kidney", "disease", "C1561643#ent", "<e1>", ")", ",", "and", "particularly", "C0035078#ent", "<e2>", "is", "associated", "with", "accelerated", "atherosclerosis", "and", "approximately", "a", "20-fold", "increased", "risk", "of", "cardiovascular", "death"], "h": {"id": "C1561643", "name": "C1561643#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [9, 10]}}
{"token": ["The", "major", "functional", "classes", "of", "C1417679#ent", "<e1>", "identified", "included", "modulators", "and", "products", "of", "C1333497#ent", "<e2>", "regulators", "of", "cell", "growth", "turnover", ",", "and", "a", "cohort", "of", "actin", "cytoskeleton", "regulatory", "proteins"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333497", "name": "C1333497#ent", "pos": [13, 14]}}
{"token": ["Ullrich", "congenital", "muscular", "dystrophy", "Bethlem", "myopathy", "skeletal", "muscle", "diseases", "are", "due", "to", "mutations", "in", "the", "C1417679#ent", "<e1>", "encoding", "collagen", "VI", "an", "C1333497#ent", "<e2>", "microfibrillar", "network", "that", "is", "particularly", "prominent", "in", "the", "endomysium", "of", "skeletal", "muscle"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333497", "name": "C1333497#ent", "pos": [21, 22]}}
{"token": ["We", "demonstrate", "that", "C3538822#ent", "<e1>", "shares", "with", "C1419227#ent", "<e2>", "the", "ability", "to", "interfere", "with", "cadherin-mediated", "adhesion"], "h": {"id": "C3538822", "name": "C3538822#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419227", "name": "C1419227#ent", "pos": [7, 8]}}
{"token": ["Autoantibodies", "against", "triosephosphate", "isomerase", "C1420737#ent", "<e1>", ")", "and", "superoxide", "dismutase", "Mn", "]", "(", "C1743497#ent", "<e2>", ")", "were", "detected", "in", "sera", "from", "over", "20", "%", "patients", "with", "LSC", "but", "none", "from", "the", "normal", "controls"], "h": {"id": "C1420737", "name": "C1420737#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [13, 14]}}
{"token": ["To", "address", "the", "issues", "of", "isoform", "redundancy", "and", "isoform", "specificity", "of", "the", "Akt", "family", "C0030940#ent", "<e1>", "in", "vivo", "we", "generated", "mice", "deficient", "in", "both", "C1312419#ent", "<e2>", "and", "Akt3", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1312419", "name": "C1312419#ent", "pos": [24, 25]}}
{"token": ["We", "have", "found", "significant", "activities", "of", "glucokinase", ",", "glucose-6-phosphatase", "and", "C0003762#ent", "<e1>", ",", "and", "considerable", "amounts", "of", "noradrenaline", "and", "C0002245#ent", "<e2>", "."], "h": {"id": "C0003762", "name": "C0003762#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [19, 20]}}
{"token": ["The", "isolates", ",", "C1426073#ent", "<e1>", "and", "MW8", ",", "were", "characterized", "as", "C1418887#ent", "<e2>", ",", "Gram-positive", "rods", "capable", "of", "fermenting", "glycerol"], "h": {"id": "C1426073", "name": "C1426073#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418887", "name": "C1418887#ent", "pos": [11, 12]}}
{"token": ["C0023524#ent", "<e1>", "NBs", "also", "contain", "C0035679#ent", "<e2>"], "h": {"id": "C0023524", "name": "C0023524#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [5, 6]}}
{"token": ["C1415498#ent", "<e1>", "immunoreactivity", "was", "low", "at", "C3273601#ent", "<e2>", "and", "P5", "and", "increased", "by", "P20", "."], "h": {"id": "C1415498", "name": "C1415498#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3273601", "name": "C3273601#ent", "pos": [6, 7]}}
{"token": ["The", "presence", "of", "albumin", ",", "considered", "as", "an", "C1510922#ent", "<e1>", "on", "the", "surface", "of", "C1421454#ent", "<e2>", "."], "h": {"id": "C1510922", "name": "C1510922#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1421454", "name": "C1421454#ent", "pos": [14, 15]}}
{"token": ["C0251914#ent", "<e1>", "GRP78", ")", "is", "implicated", "in", "cellular", "protein", "folding", "C1413374#ent", "<e2>", "responds", "to", "glucose", "deficiency"], "h": {"id": "C0251914", "name": "C0251914#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413374", "name": "C1413374#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "dietary", "cholesterol", "rat", "intestinal", "3-hydroxy-3-methylglutaryl-coenzyme", "A", "reductase", "C0000404#ent", "<e1>", "varied", "depending", "upon", "whether", "animals", "received", "the", "dietary", "cholesterol", "C0268281#ent", "<e2>", "or", "saturated", "fats"], "h": {"id": "C0000404", "name": "C0000404#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268281", "name": "C0268281#ent", "pos": [21, 22]}}
{"token": ["Vaccinating", "hospital", "personnel", "influenza", "vaccine", ",", "if", "C0021400#ent", "<e1>", "prevalent", ",", "giving", "C0936072#ent", "<e2>", "high-risk", "patients", "or", "personnel", "should", "both", "be", "considered", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0936072", "name": "C0936072#ent", "pos": [12, 13]}}
{"token": ["Nevertheless", ",", "the", "trials", "conducted", "during", "the", "C0021400#ent", "<e1>", "early", "1968", "indicated", "the", "therapeutic", "effect", "C0936072#ent", "<e2>"], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0936072", "name": "C0936072#ent", "pos": [15, 16]}}
{"token": ["Receptors", "for", "the", "secreted", "netrins", "include", "C1704789#ent", "<e1>", "(", "deleted", "in", "colorectal", "cancer", "and", "the", "UNC5", "homologues", ":", "C1421357#ent", "<e2>", ",", "B", ",", "C", "and", "D", "in", "mammals", "."], "h": {"id": "C1704789", "name": "C1704789#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421357", "name": "C1421357#ent", "pos": [18, 19]}}
{"token": ["Immunohistochemical", "(", "IHC", ")", "analysis", "was", "performed", "in", "21", "specimens", "for", "estrogen", "and", "C1366500#ent", "<e1>", "p53", ",", "Her", "2", "(", "p185", ")", ",", "and", "C2985149#ent", "<e2>", "."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2985149", "name": "C2985149#ent", "pos": [24, 25]}}
{"token": ["While", "sulpiride", "also", "decreased", "SND", "919-induced", "C1412446#ent", "<e1>", ",", "idazoxan", "at", "all", "doses", "and", "C0724441#ent", "<e2>", "at", "1", "mg/kg", "did", "not", "affect", "this", "behaviour", "."], "h": {"id": "C1412446", "name": "C1412446#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0724441", "name": "C0724441#ent", "pos": [14, 15]}}
{"token": ["Ocular", "manifestations", "C0006840#ent", "<e1>", "included", "episcleritis", ",", "C0008513#ent", "<e2>", ",", "and", "endophthalmitis", "."], "h": {"id": "C0006840", "name": "C0006840#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008513", "name": "C0008513#ent", "pos": [7, 8]}}
{"token": ["This", "confirms", "that", "we", "have", "cloned", "the", "C0017337#ent", "<e1>", "encoding", "the", "major", "microsomal", "form", "of", "C1824837#ent", "<e2>", "which", "appears", "not", "to", "be", "essential", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1824837", "name": "C1824837#ent", "pos": [15, 16]}}
{"token": ["Differentially", "expressed", "C0017337#ent", "<e1>", "included", "SPDEF", ",", "FOXA1", ",", "XBP1", ",", "C1824837#ent", "<e2>", ",", "TFF3", ",", "NAT1", ",", "APOD", ",", "ALCAM", "and", "AR", "(", "P<0.001", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1824837", "name": "C1824837#ent", "pos": [11, 12]}}
{"token": ["In", "inflamed", "mucosal", "tissue", "explants", "from", "patients", "with", "CD", ",", "inhibition", "of", "C1334470#ent", "<e1>", "also", "restores", "p-Smad3", "and", "decreases", "proinflammatory", "C1333196#ent", "<e2>", "production", ",", "an", "effect", "that", "is", "partially", "blocked", "by", "anti-TGF-beta1", "."], "h": {"id": "C1334470", "name": "C1334470#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [20, 21]}}
{"token": ["We", "therefore", "quantified", "monocytes", "expressing", "C1442762#ent", "<e1>", "and", "pTF", "levels", "in", "patients", "with", "C0149871#ent", "<e2>", "DVT", ")", "."], "h": {"id": "C1442762", "name": "C1442762#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149871", "name": "C0149871#ent", "pos": [13, 14]}}
{"token": ["Ectopic", "expression", "of", "the", "C0298973#ent", "<e1>", "AT", "cells", "increases", "the", "activation", "of", "NF-kappaB", "in", "response", "to", "C0594375#ent", "<e2>", "."], "h": {"id": "C0298973", "name": "C0298973#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [16, 17]}}
{"token": ["However", ",", "when", "2", "mM", "C1705556#ent", "<e1>", "was", "included", "in", "the", "pipette", "C0017205#ent", "<e2>", "increased", ",", "while", "Gquin", "remained", "unchanged", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017205", "name": "C0017205#ent", "pos": [12, 13]}}
{"token": ["This", "action", "of", "NE", "was", "blocked", "by", "the", "alpha", "receptor", "antagonist", "phentolamine", "and", "the", "specific", "alpha", "1", "receptor", "C0076107#ent", "<e1>", ",", "but", "not", "by", "the", "beta", "receptor", "antagonist", "timolol", "the", "alpha", "2", "receptor", "antagonist", "C0063327#ent", "<e2>", "."], "h": {"id": "C0076107", "name": "C0076107#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0063327", "name": "C0063327#ent", "pos": [34, 35]}}
{"token": ["The", "C0079405#ent", "<e1>", "was", "present", "in", "C0178664#ent", "<e2>"], "h": {"id": "C0079405", "name": "C0079405#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [6, 7]}}
{"token": ["C1145670#ent", "<e1>", "the", "major", "cause", "of", "death", "in", "patients", "with", "C0013264#ent", "<e2>", "DMD", ")", "."], "h": {"id": "C1145670", "name": "C1145670#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0013264", "name": "C0013264#ent", "pos": [10, 11]}}
{"token": ["The", "role", "of", "caffeine", "and", "other", "C3536939#ent", "<e1>", "in", "prematurity", ",", "intrauterine", "growth", "retardation", "and", "the", "C0035220#ent", "<e2>", "currently", "under", "investigation", "."], "h": {"id": "C3536939", "name": "C3536939#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [16, 17]}}
{"token": ["Deubiquinating", "enzymes", "the", "C1175888#ent", "<e1>", "ubps", ")", "and", "the", "C0164005#ent", "<e2>", "uchs", ")", ",", "remove", "ubiquitin", "from", "ubiquitinated", "substrates", "."], "h": {"id": "C1175888", "name": "C1175888#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0164005", "name": "C0164005#ent", "pos": [9, 10]}}
{"token": ["These", "data", "suggest", "that", "the", "design", "of", "novel", "C0358430#ent", "<e1>", "drugs", "acting", "at", "the", "C1704949#ent", "<e2>", "subtype", "of", "glutamate", "receptors", "be", "feasible", "."], "h": {"id": "C0358430", "name": "C0358430#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1704949", "name": "C1704949#ent", "pos": [14, 15]}}
{"token": ["C2973529#ent", "<e1>", "been", "previously", "documented", "with", "ciprofloxacin", ",", "zidovudine", ",", "C0031957#ent", "<e2>", ",", "and", "lithium", "."], "h": {"id": "C2973529", "name": "C2973529#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [10, 11]}}
{"token": ["CCL4", "and", "C1824662#ent", "<e1>", "are", "two", "CC", "chemokine", "genes", "at", "chromosome", "17q21", "mature", "C0086376#ent", "<e2>", "differ", "at", "only", "a", "single", "amino", "acid"], "h": {"id": "C1824662", "name": "C1824662#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [13, 14]}}
{"token": ["Plants", "homozygous", "for", "cap1", "C0002085#ent", "<e1>", "show", "a", "reduction", "in", "stature", "and", "C0377148#ent", "<e2>", "disruption", "of", "multiple", "cell", "types"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [12, 13]}}
{"token": ["The", "antisera", "to", "C1417087#ent", "<e1>", "specific", "for", "this", "C0027203#ent", "<e2>", "."], "h": {"id": "C1417087", "name": "C1417087#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["Resting", "C1538586#ent", "<e1>", "CD4+", "T", "cells", "constitutively", "express", "high", "levels", "of", "HLA-DP", ",", "lymphocyte", "function-associated", "antigen", "1", "C1706332#ent", "<e2>", ")", "and", "ICAM-3", "."], "h": {"id": "C1538586", "name": "C1538586#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706332", "name": "C1706332#ent", "pos": [17, 18]}}
{"token": ["Finally", ",", "a", "dominant", "inhibitory", "form", "of", "C0812284#ent", "<e1>", "suppresses", "the", "transforming", "activities", "both", "C0521471#ent", "<e2>", "and", "Raf", "."], "h": {"id": "C0812284", "name": "C0812284#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0521471", "name": "C0521471#ent", "pos": [14, 15]}}
{"token": ["The", "N", "terminus", "but", "not", "the", "N-terminal", "truncation", "of", "p73", "bound", "to", "the", "CH1", "domain", "(", "C3539946#ent", "<e1>", "aa", "]", "350", "to", "450", ")", "of", "C3887789#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3887789", "name": "C3887789#ent", "pos": [25, 26]}}
{"token": ["The", "C0720099#ent", "<e1>", "of", "indirect", "C1419999#ent", "<e2>", "gates", "based", "on", "broadband", "geodesic", "sequence", "is", "reduced", "by", "42.3", "%", "compared", "to", "conventional", "approaches", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419999", "name": "C1419999#ent", "pos": [5, 6]}}
{"token": ["We", "report", "two", "patients", "on", "long-term", "C0014710#ent", "<e1>", "treatment", "who", "developed", "C3274794#ent", "<e2>"], "h": {"id": "C0014710", "name": "C0014710#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3274794", "name": "C3274794#ent", "pos": [11, 12]}}
{"token": ["Both", "the", "Apc", "and", "C0536678#ent", "<e1>", "(", "candidate", "for", "C1335221#ent", "<e2>", ")", "genes", "were", "sequenced", "and", "found", "to", "be", "identical", "for", "both", "the", "Apc(+/Min-FCCC", ")", "and", "Apc(+/Min-JAX", ")", "mouse", "strains", "."], "h": {"id": "C0536678", "name": "C0536678#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335221", "name": "C1335221#ent", "pos": [9, 10]}}
{"token": ["To", "determine", "the", "distribution", "of", "C0035690#ent", "<e1>", "an", "outbreak", "of", "C0014057#ent", "<e2>", "JE", ")", "in", "the", "Torres", "Strait", ",", "and", "to", "describe", "the", "environmental", "factors", "the", "outbreak", "."], "h": {"id": "C0035690", "name": "C0035690#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014057", "name": "C0014057#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "C0528023#ent", "<e1>", "on", "antiatherogenic", "properties", "high-density", "lipoproteins", "studied", "in", "patients", "with", "C1956346#ent", "<e2>", "hyperlipidemia", "."], "h": {"id": "C0528023", "name": "C0528023#ent", "pos": [3, 4]}, "relation": "may_prevent", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["C0751495#ent", "<e1>", "and", "mental", "abnormalities", "excellently", "to", "C3539185#ent", "<e2>", "only", ",", "supporting", "the", "view", "that", "encephalopathy", "could", "be", "the", "clinical", "manifestation", "autoimmune", "cerebral", "vasculitis"], "h": {"id": "C0751495", "name": "C0751495#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539185", "name": "C3539185#ent", "pos": [7, 8]}}
{"token": ["Here", ",", "we", "examined", "the", "effects", "of", "C0242911#ent", "<e1>", "learning", "using", "a", "passive", "avoidance", "C1416596#ent", "<e2>", "in", "rats", "."], "h": {"id": "C0242911", "name": "C0242911#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [14, 15]}}
{"token": ["Thirty-six", "different", "normal", "tissues", "13", "different", "malignant", "epithelial", "tumours", "were", "examined", "immunohistochemically", "for", "the", "presence", "of", "protein", "1", "C1418887#ent", "<e1>", ")", "and", "Clara", "cell", "10-kDa", "protein", "(", "C1421318#ent", "<e2>", ")", "."], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1421318", "name": "C1421318#ent", "pos": [27, 28]}}
{"token": ["The", "double", "mutant", "D97R", "and", "S267I", ")", "receptors", "were", "both", "C0669365#ent", "<e1>", "active", "and", "resistant", "to", "the", "enhancing", "effects", "of", "ethanol", "and", "C0014277#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014277", "name": "C0014277#ent", "pos": [22, 23]}}
{"token": ["This", "method", "is", "suitable", "as", "a", "screen", "for", "cystinuria", "in", "patients", "with", "C0392525#ent", "<e1>", "for", "ongoing", "monitoring", "of", "C0010691#ent", "<e2>", "patients", "and", "to", "check", "patient", "compliance", "with", "d-penicillamine", "therapy", "."], "h": {"id": "C0392525", "name": "C0392525#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0010691", "name": "C0010691#ent", "pos": [18, 19]}}
{"token": ["By", "immunogold", "labeling", "and", "negative", "staining", "have", "detected", "in", "these", "complexes", ",", "myc-NSF", ",", "syntaxin", ",", "C1119970#ent", "<e1>", ",", "caveolin", ",", "and", "endogenous", "C1417857#ent", "<e2>", "."], "h": {"id": "C1119970", "name": "C1119970#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417857", "name": "C1417857#ent", "pos": [23, 24]}}
{"token": ["This", "study", "concerned", "the", "identification", "of", "the", "beta-thalassaemia", "mutations", "that", "were", "present", "in", "27", "Malay", "patients", "with", "C0005283#ent", "<e1>", "seven", "Malay", "patients", "with", "C0039730#ent", "<e2>", "major", "who", "were", "from", "West", "Malaysia"], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [17, 18]}, "relation": "has_nichd_parent", "t": {"id": "C0039730", "name": "C0039730#ent", "pos": [23, 24]}}
{"token": ["This", "study", "was", "undertaken", "to", "compare", "Doppler", "echocardiographic", "parameters", "of", "diastolic", "function", "a", "group", "of", "patients", "with", "C0005283#ent", "<e1>", "major", ",", "a", "group", "with", "C0039730#ent", "<e2>", "a", "group", "of", "normal", "individuals", "."], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [17, 18]}, "relation": "has_nichd_parent", "t": {"id": "C0039730", "name": "C0039730#ent", "pos": [24, 25]}}
{"token": ["We", "found", "that", "hypoxia", "induced", "ER", "stress", "as", "assessed", "by", "the", "expression", "of", "C2985165#ent", "<e1>", "and", "BiP", "and", "cleavage", "of", "C0010656#ent", "<e2>"], "h": {"id": "C2985165", "name": "C2985165#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [20, 21]}}
{"token": ["To", "determine", "diagnostic", "criteria", "C0041323#ent", "<e1>", "among", "sputum", "smear", "acid", "fast", "bacilli", "negative", "patients", "with", "C0010201#ent", "<e2>", "based", "on", "symptoms", ",", "signs", "and", "simple", "laboratory", "tests"], "h": {"id": "C0041323", "name": "C0041323#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010201", "name": "C0010201#ent", "pos": [15, 16]}}
{"token": ["These", "cells", "also", "acquired", "functional", "characteristics", "of", "hepatocytes", ":", "they", "secreted", "urea", "and", "albumin", ",", "had", "C1413868#ent", "<e1>", "could", "take", "up", "LDL", ",", "and", "stored", "C0002245#ent", "<e2>", "."], "h": {"id": "C1413868", "name": "C1413868#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [25, 26]}}
{"token": ["Among", "these", "C0035064#ent", "<e1>", "are", "3-hydroxy-3-methylglutaryl-coenzyme", "A", "reductase", "inhibitors", "statins", ")", ",", "erythropoietin", "(", "C1414438#ent", "<e2>", ")", ",", "and", "phosphodiesterase", "type", "5", "PDE-5", ")", "inhibitors", "and", "nitric", "oxide", "NO", ")", "donors", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414438", "name": "C1414438#ent", "pos": [14, 15]}}
{"token": ["This", "C0039082#ent", "<e1>", "is", "also", "known", "as", "achalasia-addisonianism-alacrima", "syndrome", "C0221033#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0221033", "name": "C0221033#ent", "pos": [9, 10]}}
{"token": ["Crystalline", "C1419184#ent", "<e1>", "nicotinatenucleotide", ":", "pyrophosphate", "phosphoribosyltransferase", "carboxylating", ")", ",", "C1531278#ent", "<e2>", "was", "isolated", "from", "hog", "kidney", "compared", "with", "the", "same", "enzyme", "prepared", "from", "hog", "liver", "."], "h": {"id": "C1419184", "name": "C1419184#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1531278", "name": "C1531278#ent", "pos": [10, 11]}}
{"token": ["Localization", "and", "pharmacological", "properties", "of", "C1366646#ent", "<e1>", "VIP", ")", "binding", "sites", "investigated", "in", "C0235267#ent", "<e2>", "from", "albino", "rabbits", "rats", "using", "an", "in", "vitro", "autoradiographic", "method"], "h": {"id": "C1366646", "name": "C1366646#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [13, 14]}}
{"token": ["Bradwejn", "and", "De", "Montigny", "have", "recently", "shown", "that", "C0005064#ent", "<e1>", "selectively", "inhibit", "excitation", "of", "hippocampal", "neurones", "by", "cholecystokinin", "(", "C1413167#ent", "<e2>", ")", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413167", "name": "C1413167#ent", "pos": [19, 20]}}
{"token": ["The", "techniques", "used", "were", "one-dimensional", "(", "1-D", ")", "mapping", "of", "C1318973#ent", "<e1>", "peptides", "and", "two-dimensional", "(", "2-D", ")", "mapping", "of", "C1413806#ent", "<e2>"], "h": {"id": "C1318973", "name": "C1318973#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413806", "name": "C1413806#ent", "pos": [20, 21]}}
{"token": ["C1857277#ent", "<e1>", "associated", "with", "agenesis", "of", "the", "corpus", "callosum", "congenital", "diaphragmatic", "hernia", "facial", "dysmorphology", "ocular", "anomalies", "C0018784#ent", "<e2>", "developmental", "delay"], "h": {"id": "C1857277", "name": "C1857277#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [16, 17]}}
{"token": ["The", "effect", "of", "age", "and", "weaning", "on", "C0014442#ent", "<e1>", "activities", "of", "abomasum", "and", "pancreas", "of", "the", "C0406810#ent", "<e2>", "was", "studied", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0406810", "name": "C0406810#ent", "pos": [16, 17]}}
{"token": ["The", "patient", "presented", "with", "generalized", "symptoms", "an", "initial", "C0155862#ent", "<e1>", "then", "developed", "respiratory", "and", "cardiac", "failure", "ventilation", "and", "C0304509#ent", "<e2>"], "h": {"id": "C0155862", "name": "C0155862#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0304509", "name": "C0304509#ent", "pos": [18, 19]}}
{"token": ["Selection", "for", "increased", "C1842690#ent", "<e1>", "will", "slightly", "increase", "C2699751#ent", "<e2>", "and", "reduce", "the", "probability", "of", "a", "return", "."], "h": {"id": "C1842690", "name": "C1842690#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2699751", "name": "C2699751#ent", "pos": [8, 9]}}
{"token": ["Topically", "applied", "C0733381#ent", "<e1>", "reduced", "arachidonic", "acid", "or", "tetradecanoyl", "phorbol", "acetate", "ear", "inflammation", "ED50s", ":", "AA-induced", "C0013604#ent", "<e2>", "1.4", "mg/ear", ";", "PMA-induced", "C0013604#ent", "<e2>", "0.013", "mg/ear", ")", "."], "h": {"id": "C0733381", "name": "C0733381#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [16, 17]}}
{"token": ["The", "deep", "layer", "the", "C0015644#ent", "<e1>", "caudally", "from", "the", "C1853235#ent", "<e2>", "intimate", "contact", "recti", "and", "oblique", "muscles", "the", "eyeball", "."], "h": {"id": "C0015644", "name": "C0015644#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1853235", "name": "C1853235#ent", "pos": [9, 10]}}
{"token": ["C1705011#ent", "<e1>", "treatment", "of", "whole", "Arabidopsis", "seedlings", "also", "resulted", "in", "C0108471#ent", "<e2>", "secretion", ",", "indicating", "that", "the", "drug", "has", "a", "similar", "mode", "of", "action", "in", "cells", "and", "intact", "plants", "."], "h": {"id": "C1705011", "name": "C1705011#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [10, 11]}}
{"token": ["The", "ability", "of", "blood", "mononuclear", "cells", "MNC", ")", "to", "produce", "burst", "promoting", "activity", "(", "C3539739#ent", "<e1>", ")", "was", "evaluated", "in", "31", "patients", "with", "C1561643#ent", "<e2>"], "h": {"id": "C3539739", "name": "C3539739#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [23, 24]}}
{"token": ["We", "examined", "the", "cardiovascular", ",", "plasma", "norepinephrine", "NE", ")", ",", "and", "plasma", "renin", "C3274822#ent", "<e1>", ")", "responses", "to", "isoproterenol", "infusion", "in", "patients", "with", "C0037019#ent", "<e2>", "in", "normal", "subjects"], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [23, 24]}}
{"token": ["Furthermore", ",", "the", "addition", "of", "beta-globulin", "to", "C2698717#ent", "<e1>", "stimulated", "steroid", "hormone", "biosynthesis", "a", "marked", "increase", "in", "11", "C1413856#ent", "<e2>", "production", "."], "h": {"id": "C2698717", "name": "C2698717#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413856", "name": "C1413856#ent", "pos": [18, 19]}}
{"token": ["The", "higher", "C0669365#ent", "<e1>", "expression", "of", "C1415326#ent", "<e2>", "glutaredoxin", "could", "potentially", "confer", "neuroprotection", "to", "female", "mice"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415326", "name": "C1415326#ent", "pos": [6, 7]}}
{"token": ["The", "C0021699#ent", "<e1>", "encoded", "by", "C3812243#ent", "<e2>", ",", "is", "located", "at", "the", "basolateral", "membrane", "the", "retinal", "pigment", "epithelium", "in", "which", "it", "probably", "functions", "as", "a", "Cl(-", ")", "channel", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3812243", "name": "C3812243#ent", "pos": [5, 6]}}
{"token": ["The", "salts", "were", "synthesised", "by", "quaternarization", "of", "C0072780#ent", "<e1>", "dihydrocinnamic", "acid", "n-alkoxymethyl", "bromides", "(", "PYA-n", ")", "or", "quaternarization", "of", "C0011064#ent", "<e2>", "n-alkyl", "bromides", "(", "PPA-n", ")", "."], "h": {"id": "C0072780", "name": "C0072780#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011064", "name": "C0011064#ent", "pos": [19, 20]}}
{"token": ["The", "mechanism", "triggered", "involved", "a", "beta-adrenergic", "reaction", "could", "be", "blocked", "by", "10(-7", ")", "M", "(-)-propranolol", "and", "10(-6", ")", "M", "C0282081#ent", "<e1>", "and", "potentiated", "by", "chemical", "sympathectomy", "the", "mice", "with", "C0085196#ent", "<e2>", "."], "h": {"id": "C0282081", "name": "C0282081#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0085196", "name": "C0085196#ent", "pos": [29, 30]}}
{"token": ["Immunofluorescence", "studies", "the", "presence", "of", "immunoproteins", "and", "the", "A1AT", "protein", "isoelectric", "forms", ",", "C1709403#ent", "<e1>", "and", "PiZ", ",", "in", "the", "subendothelial", "region", "glomerular", "basement", "membranes", "C1418544#ent", "<e2>", "patients", "with", "MPGN", ",", "Mes", "GN", "and", "DPGN", "."], "h": {"id": "C1709403", "name": "C1709403#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418544", "name": "C1418544#ent", "pos": [25, 26]}}
{"token": ["The", "effect", "of", "BLAP75", "on", "BLM-Topo", "IIIalpha", "is", "highly", "specific", ",", "as", "it", "is", "not", "seen", "with", "the", "combination", "of", "Topo", "IIIalpha", "Escherichia", "coli", "C1335609#ent", "<e1>", "another", "human", "C1506962#ent", "<e2>", "WRN", "."], "h": {"id": "C1335609", "name": "C1335609#ent", "pos": [24, 25]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1506962", "name": "C1506962#ent", "pos": [28, 29]}}
{"token": ["Regulation", "of", "genetic", "recombination", "a", "proposed", "role", "for", "C1335609#ent", "<e1>", "is", "supported", "by", "the", "identified", "C1506962#ent", "<e2>", "interactions", "and", "is", "discussed", "."], "h": {"id": "C1335609", "name": "C1335609#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1506962", "name": "C1506962#ent", "pos": [15, 16]}}
{"token": ["The", "result", "suggests", "that", "C1565919#ent", "<e1>", "translocation", "and", "activation", "can", "phosphorylate", "C1522505#ent", "<e2>", "in", "CNE-2", "cells", "and", "increase", "C1522505#ent", "<e2>", "release", "."], "h": {"id": "C1565919", "name": "C1565919#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522505", "name": "C1522505#ent", "pos": [11, 12]}}
{"token": ["Acne", "and", "C0036508#ent", "<e1>", "(", "or", "facial", "oiliness", ")", "are", "related", "C0037274#ent", "<e2>", "affect", "a", "high", "proportion", "of", "women", "after", "menarche", "."], "h": {"id": "C0036508", "name": "C0036508#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [11, 12]}}
{"token": ["The", "rat", "preprotachykinin", "(", "PPT", ")", "C0079429#ent", "<e1>", "encoding", "the", "neuropeptides", "substance", "P", "SP", ")", ",", "C1420563#ent", "<e2>", "NKA", ")", ",", "neuropeptide", "K", "NPK", ")", ",", "and", "neuropeptide", "gamma", "isolated", "from", "a", "lambda", "Charon", "4A", "genomic", "library"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420563", "name": "C1420563#ent", "pos": [16, 17]}}
{"token": ["Outbreaks", "of", "foot", "and", "mouth", "disease", "FMD", ")", ",", "African", "swine", "fever", "ASF", ")", ",", "C0019841#ent", "<e1>", "CSF", ")", "and", "C0039010#ent", "<e2>", "SVD", ")", "can", "cause", "significant", "economic", "and", "social", "costs", "severe", "trade", "limitations", "."], "h": {"id": "C0019841", "name": "C0019841#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0039010", "name": "C0039010#ent", "pos": [20, 21]}}
{"token": ["NGF", "responses", "(", "cPLA(2)alpha", "mRNA", "and", "its", "protein", ")", "were", "inhibited", "by", "C0003015#ent", "<e1>", "the", "ERK1/2", "pathway", ",", "C0257535#ent", "<e2>", "c-Jun", "NH(2)-terminal", "kinase"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0257535", "name": "C0257535#ent", "pos": [18, 19]}}
{"token": ["We", "have", "previously", "identified", "a", "nuclear-matrix-associated", "region", "C1706474#ent", "<e1>", ")", "of", "the", "C0086661#ent", "<e2>", "protooncogene", "to", "reside", "in", "a", "1.4-kb", "region", "between", "Cla", "I", "Eco", "RI", "restriction", "sites", "the", "3'-end", "of", "the", "gene", "."], "h": {"id": "C1706474", "name": "C1706474#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [12, 13]}}
{"token": ["Data", "from", "multicenter", "studies", "pregnant", "and", "nonpregnant", "women", "in", "Belgium", "and", "Luxembourg", "indicate", "that", "the", "efficacy", "of", "C0076115#ent", "<e1>", "superior", "to", "that", "of", "C0086620#ent", "<e2>", "clotrimazole", "cream"], "h": {"id": "C0076115", "name": "C0076115#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0086620", "name": "C0086620#ent", "pos": [23, 24]}}
{"token": ["HGF/SF", "induces", "the", "expression", "of", "C0042071#ent", "<e1>", "uPA", ")", "and", "the", "uPA", "receptor", "uPAR", ")", ",", "important", "C0127400#ent", "<e2>", "of", "cell", "invasion", "metastasis", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [17, 18]}}
{"token": ["In", "both", "instances", "C0036572#ent", "<e1>", "the", "presenting", "features", "with", "radiological", "and", "biochemical", "evidence", "of", "C0035579#ent", "<e2>", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [14, 15]}}
{"token": ["The", "diagnosis", "of", "C0265233#ent", "<e1>", "based", "on", "C0027726#ent", "<e2>", "diffuse", "mesangial", "sclerosis", "to", "chronic", "renal", "failure", "dysgenetic", "gonads", "46", "XY", "karyotype", "a", "phenotypic", "female", ",", "and", "a", "mutation", "in", "the", "Wilms'", "tumor", "gene"], "h": {"id": "C0265233", "name": "C0265233#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [7, 8]}}
{"token": ["The", "C1418370#ent", "<e1>", "decreased", "the", "transfer", "of", "both", "triglyceride", "and", "C0008385#ent", "<e2>", "all", "pairs", "of", "very", "low", ",", "low", ",", "and", "high", "density", "lipoproteins"], "h": {"id": "C1418370", "name": "C1418370#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [10, 11]}}
{"token": ["Molecular", "genetic", "study", "such", "large", "families", "should", "allow", "identification", "of", "C1417679#ent", "<e1>", "relevant", "to", "C0015967#ent", "<e2>", "seizures", "and", "generalized", "epilepsies"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [14, 15]}}
{"token": ["C4042483#ent", "<e1>", "only", "detected", "at", "P5", "and", "C1704968#ent", "<e2>", ",", "while", "detection", "of", "Bcl-xL", "and", "Bax", "proteins", "levels", "of", "mRNA", "expression", "."], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704968", "name": "C1704968#ent", "pos": [7, 8]}}
{"token": ["The", "conformational", "properties", "of", "CP-10(42", "-", "55", ")", ",", "a", "C0030956#ent", "<e1>", "corresponding", "to", "the", "hinge", "region", "C0259714#ent", "<e2>", ",", "were", "investigated", "using", "circular", "dichroism", "spectroscopy", "reverse-phase", "high-performance", "liquid", "chromatography", "RP-HPLC", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0259714", "name": "C0259714#ent", "pos": [17, 18]}}
{"token": ["However", ",", "growing", "evidence", "suggests", "that", "an", "C0001622#ent", "<e1>", "of", "nitric", "oxide", "to", "muscle", "wasting", "a", "number", "of", "pathologies", "including", "C0018802#ent", "<e2>", "sepsis", ",", "COPD", ",", "muscular", "dystrophy", "and", "extreme", "disuse", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [20, 21]}}
{"token": ["A", "38-year-old", "Asian", "man", "presented", "with", "acute", "pancreatitis", "marked", "C0020557#ent", "<e1>", "and", "macroproteinuria", ",", "20", "years", "after", "the", "diagnosis", "of", "C0023194#ent", "<e2>", "LCAT", ")", "deficiency", "."], "h": {"id": "C0020557", "name": "C0020557#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023194", "name": "C0023194#ent", "pos": [20, 21]}}
{"token": ["This", "study", "examined", "the", "effects", "of", "acute", "and", "chronic", "desipramine", ",", "24-h", "total", "sleep", "deprivation", "C1332805#ent", "<e1>", ")", "and", "96-h", "REM", "sleep", "deprivation", "(", "C0268263#ent", "<e2>", ")", "on", "physostigmine-induced", "hypothermia", ",", "analgesia", "and", "behaviour", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0268263", "name": "C0268263#ent", "pos": [24, 25]}}
{"token": ["Both", "compound", "13", "the", "antimalarial", "drug", "C0072768#ent", "<e1>", "inhibited", "the", "decatenation", "activity", "of", "P.", "falciparum", "C0012863#ent", "<e2>", "concentrations", "of", "10", "and", "11", "microM", ",", "respectively", "."], "h": {"id": "C0072768", "name": "C0072768#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012863", "name": "C0012863#ent", "pos": [15, 16]}}
{"token": ["Numerous", "factors", "influence", "the", "absorption", "of", "C1419070#ent", "<e1>", "antibiotics", ",", "including", "the", "C0011947#ent", "<e2>", ",", "the", "dwell", "period", ",", "protein", "binding", "distribution", "volume", "and", "presence", "or", "absence", "of", "peritonitis", "."], "h": {"id": "C1419070", "name": "C1419070#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011947", "name": "C0011947#ent", "pos": [12, 13]}}
{"token": ["We", "have", "compared", "the", "effects", "of", "pre-administration", "versus", "post-administration", "of", "a", "potent", "non-selective", "cannabinoid", "agonist", "C0526470#ent", "<e1>", "and", "a", "selective", "CB2", "receptor", "C0968642#ent", "<e2>", "on", "hindpaw", "weight", "bearing", "and", "paw", "oedema", "the", "carrageenan", "model", "of", "inflammatory", "hyperalgesia"], "h": {"id": "C0526470", "name": "C0526470#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0968642", "name": "C0968642#ent", "pos": [22, 23]}}
{"token": ["PKC", "inhibitors", "C0075193#ent", "<e1>", "and", "calphostin", "C", "modified", "neither", "reperfusion", "arrhythmias", "the", "antiarrhythmic", "effect", "C3811118#ent", "<e2>", "on", "reperfusion", "VT", "and", "VF", "."], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [14, 15]}}
{"token": ["C0075193#ent", "<e1>", "prevented", "these", "beneficial", "effects", "in", "C3811118#ent", "<e2>", "and", "S", "groups"], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [7, 8]}}
{"token": ["Interestingly", ",", "core", "Mediator", "subunits", "MED1", "and", "MED17", "are", "recruited", "to", "the", "C3470429#ent", "<e1>", "locus", "regardless", "of", "the", "C1334537#ent", "<e2>", "stimuli", "utilized", "."], "h": {"id": "C3470429", "name": "C3470429#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334537", "name": "C1334537#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "addition", "of", "exogenous", "PGE2", "to", "pfHz-treated", "PBMCs", "dose-dependently", "decreased", "C0812246#ent", "<e1>", "production", ",", "whereas", "experimental", "COX", "inhibitors", "C0280004#ent", "<e2>", "used", "during", "human", "malaria", "generated", "increased", "C0812246#ent", "<e1>", "production", "."], "h": {"id": "C0280004", "name": "C0280004#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}}
{"token": ["Expression", "of", "C0030016#ent", "<e1>", "a", "mutation", "in", "the", "C1335186#ent", "<e2>", "and", "fully", "reversed", "the", "ketoconazole", "sensitive", "phenotype", "of", "the", "respective", "strain", "."], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335186", "name": "C1335186#ent", "pos": [8, 9]}}
{"token": ["Since", "C0017083#ent", "<e1>", "are", "thought", "to", "protect", "neurons", "from", "excitotoxic", "effects", "C0243046#ent", "<e2>", "these", "results", "suggest", "that", "ganglioside", "treatment", "may", "result", "in", "attenuation", "of", "excitatory", "neurotoxicity", "that", "may", "occur", "following", "peripheral", "nerve", "injury"], "h": {"id": "C0017083", "name": "C0017083#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [11, 12]}}
{"token": ["They", "use", "repeated", "doses", "of", "Heparin", "as", "an", "C0003280#ent", "<e1>", "and", "for", "its", "C0597668#ent", "<e2>", "action", "following", "the", "delivery", "."], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0597668", "name": "C0597668#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "strongly", "suggest", "that", "Ala", "overproduced", "by", "the", "C0023899#ent", "<e1>", "acts", "by", "mimicking", "the", "effect", "of", "gamma-aminobutyric", "acid", "pineal", "melatonin", "C1412302#ent", "<e2>", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412302", "name": "C1412302#ent", "pos": [21, 22]}}
{"token": ["Of", "the", "18", "recipients", ",", "nine", "had", "EHBA", ",", "four", "had", "fulminant", "hepatic", "failure", "two", "had", "C1879362#ent", "<e1>", ",", "one", "had", "C0017919#ent", "<e2>", "one", "had", "Indian", "childhood", "cirrhosis", ",", "and", "one", "had", "idiopathic", "cirrhosis"], "h": {"id": "C1879362", "name": "C1879362#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017919", "name": "C0017919#ent", "pos": [21, 22]}}
{"token": ["The", "last", "C0014442#ent", "<e1>", "in", "this", "pathway", ",", "namely", "C0079115#ent", "<e2>", "seems", "to", "be", "accessible", "to", "substrate", "from", "the", "cell", "exterior", ",", "indicating", "its", "presence", "in", "the", "plasma", "membrane"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079115", "name": "C0079115#ent", "pos": [9, 10]}}
{"token": ["Alignment", "analysis", "revealed", "that", "ChsZ", "was", "less", "homologous", "to", "known", "class", "V", "C0014442#ent", "<e1>", ",", "except", "for", "its", "probable", "C0079115#ent", "<e2>", "region", "in", "the", "C-terminal", "half"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0079115", "name": "C0079115#ent", "pos": [19, 20]}}
{"token": ["Patients", "can", "be", "asymptomatic", "or", "present", "with", "symptoms", "like", "C0004093#ent", "<e1>", ",", "hypertension", "or", "C0022650#ent", "<e2>", "."], "h": {"id": "C0004093", "name": "C0004093#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022650", "name": "C0022650#ent", "pos": [14, 15]}}
{"token": ["Folate", "transporter", "C0017337#ent", "<e1>", ",", "including", "the", "reduced", "folate", "carrier", "gene", "C3538834#ent", "<e2>", ")", ",", "have", "been", "proposed", "as", "NTD", "risk", "factors"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3538834", "name": "C3538834#ent", "pos": [11, 12]}}
{"token": ["A", "22-month-old", "girl", "with", "the", "C1848862#ent", "<e1>", "of", "hypoventilation", ",", "pulmonary", "hypertension", "C0034072#ent", "<e2>", "pulmonary", "edema", "to", "adenoidal", "hypertrophy", "described", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [12, 13]}}
{"token": ["We", "report", "on", "the", "clinical", ",", "pathological", ",", "and", "C1517495#ent", "<e1>", "7", "patients", "with", "C0686353#ent", "<e2>", "LGMD2A", ")", "from", "three", "Japanese", "families", "."], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0686353", "name": "C0686353#ent", "pos": [14, 15]}}
{"token": ["Conversion", "of", "polymannose-type", "oligosaccharides", "to", "complex-type", "oligosaccharides", "evaluated", "by", "sensitivity", "to", "C0014159#ent", "<e1>", "alpha-mannosidase", ",", "and", "with", "a", "specific", "inhibitor", "of", "C0002272#ent", "<e2>", "I/II", "."], "h": {"id": "C0014159", "name": "C0014159#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [21, 22]}}
{"token": ["The", "sex", "differences", "most", "prominent", "in", "C0010068#ent", "<e1>", "lung", "cancer", "fatal", "accidents", "suicide", "and", "C0023890#ent", "<e2>"], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [14, 15]}}
{"token": ["We", "also", "observed", "that", "the", "cytoplasmic", "domain", "C1413931#ent", "<e1>", "interacts", "with", "CCS", ",", "the", "dedicated", "copper", "chaperone", "for", "C0669516#ent", "<e2>", "(", "superoxide", "dismutase", "1", "."], "h": {"id": "C1413931", "name": "C1413931#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [18, 19]}}
{"token": ["The", "overall", "urinary", "recoveries", "metabolites", "for", "the", "2-", "and", "3-fluorobenzyl", "alcohols", "lower", "than", "that", "observed", "for", "the", "corresponding", "C0600423#ent", "<e1>", "that", "for", "C0005100#ent", "<e2>", "similar", "."], "h": {"id": "C0600423", "name": "C0600423#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0005100", "name": "C0005100#ent", "pos": [22, 23]}}
{"token": ["Therefore", "aceF", "is", "likely", "to", "encode", "a", "bifunctional", "enzyme", "with", "C1418674#ent", "<e1>", "PMI", ")", "and", "C0065685#ent", "<e2>", "GMP", ")", "activities", "."], "h": {"id": "C1418674", "name": "C1418674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0065685", "name": "C0065685#ent", "pos": [15, 16]}}
{"token": ["The", "Grand", "Round", "based", "on", "two", "case", "reports", "a", "patient", "with", "type", "2", "diabetes", "pronounced", "C0007820#ent", "<e1>", "another", "patient", "with", "early", "C0042373#ent", "<e2>", "with", "the", "macrovascular", "complications", "."], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "repeated", "administration", "of", "the", "C3540020#ent", "<e1>", "increased", "thyroxine-metabolizing", "activity", "via", "induction", "of", "C1259497#ent", "<e2>", ",", "and", "this", "induction", "by", "pantoprazole", "was", "less", "pronounced", "than", "that", "by", "omeprazole", "or", "lansoprazole", "."], "h": {"id": "C3540020", "name": "C3540020#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1259497", "name": "C1259497#ent", "pos": [14, 15]}}
{"token": ["These", "findings", "are", "consistent", "with", "studies", "showing", "a", "decrease", "in", "5-HT", "receptors", "the", "chronic", "treatment", "C0009035#ent", "<e1>", "and", "an", "absence", "of", "effect", "on", "5-HT", "receptors", "the", "chronic", "treatment", "C0009010#ent", "<e2>", "."], "h": {"id": "C0009035", "name": "C0009035#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0009010", "name": "C0009010#ent", "pos": [28, 29]}}
{"token": ["A", "1.5-kb", "DNA", "fragment", "embracing", "C1823589#ent", "<e1>", "and", "the", "C0017337#ent", "<e2>", "all", "of", "the", "genetic", "information", "for", "stable", "integration", "of", "a", "nonreplicative", "plasmid", "into", "the", "attB", "site", "of", "a", "pneumococcal", "strain"], "h": {"id": "C1823589", "name": "C1823589#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["Finally", ",", "it", "was", "noted", "that", "more", "than", "80", "%", "of", "patients", "with", "high", "C1417807#ent", "<e1>", "titres", "demonstrated", "autoantibodies", "to", "C1425409#ent", "<e2>", "and/or", "dsDNA", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1425409", "name": "C1425409#ent", "pos": [20, 21]}}
{"token": ["The", "C1822794#ent", "<e1>", "uptake", "was", "correlated", "to", "C1705603#ent", "<e2>", "expression", "with", "r", "=", "0.83", "and", "to", "Hk", "expression", "r", "=", "0.77", "."], "h": {"id": "C1822794", "name": "C1822794#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705603", "name": "C1705603#ent", "pos": [7, 8]}}
{"token": ["This", "paper", "describes", "development", "of", "the", "first", "nanostructured", "biosensor", "interface", "containing", "a", "catalytically", "active", "fragment", "of", "C1417861#ent", "<e1>", "known", "as", "C3470496#ent", "<e2>", "."], "h": {"id": "C1417861", "name": "C1417861#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3470496", "name": "C3470496#ent", "pos": [20, 21]}}
{"token": ["A", "C1514555#ent", "<e1>", "dihydrosphingosine", ",", "inhibited", "the", "release", "of", "C1413309#ent", "<e2>", "in", "response", "to", "both", "ETX", "and", "OZ", "."], "h": {"id": "C1514555", "name": "C1514555#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1413309", "name": "C1413309#ent", "pos": [9, 10]}}
{"token": ["The", "\"", "Erythrodeformeter", "\"", "allows", "obtaining", "the", "stationary", "and", "C1119970#ent", "<e1>", "linear", "parameters", "of", "C1420193#ent", "<e2>", "laser", "diffractometry", "."], "h": {"id": "C1119970", "name": "C1119970#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420193", "name": "C1420193#ent", "pos": [14, 15]}}
{"token": ["The", "glitazones", "(", "or", "thiazolidinediones", ")", "are", "synthetic", "compounds", "in", "C0011854#ent", "<e1>", "but", "they", "also", "have", "broad", "C1413240#ent", "<e2>", "and", "anti-inflammatory", "properties", "still", "not", "well", "understood", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [17, 18]}}
{"token": ["The", "relationship", "of", "C0039286#ent", "<e1>", "effect", "with", "the", "genetic", "polymorphisms", "estrogen", "receptor", "and", "C1414462#ent", "<e2>", "also", "studied", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414462", "name": "C1414462#ent", "pos": [13, 14]}}
{"token": ["This", "finding", "has", "linked", "three", "common", "factors", ",", "C1335625#ent", "<e1>", ",", "JNK", ",", "and", "C1623430#ent", "<e2>", ",", "to", "the", "cAMP", "signaling", "pathway", "to", "increased", "steroidogenic", "gene", "expression", "."], "h": {"id": "C1335625", "name": "C1335625#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [14, 15]}}
{"token": ["Mice", "deficient", "in", "FA", "proteins", "such", "as", "FANCL", ",", "C1414529#ent", "<e1>", "and", "FANCA", ",", "have", "a", "drastic", "reduction", "of", "C1426084#ent", "<e2>", "PGC", ")", ",", "resulting", "in", "male", "and", "female", "infertility", "in", "adult", "."], "h": {"id": "C1414529", "name": "C1414529#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1426084", "name": "C1426084#ent", "pos": [19, 20]}}
{"token": ["In", "children", ",", "vasovagal", "syncope", "C1836438#ent", "<e1>", ")", "is", "the", "most", "common", "cause", "of", "syncope", "and", "C0721797#ent", "<e2>", "MS", ")", "is", "also", "very", "frequent", ",", "with", "many", "symptoms", "of", "an", "autonomic", "nature"], "h": {"id": "C1836438", "name": "C1836438#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0721797", "name": "C0721797#ent", "pos": [16, 17]}}
{"token": ["C0041234#ent", "<e1>", "American", "trypanosomiasis", "is", "a", "potentially", "lethal", "C0043528#ent", "<e2>", "prevalent", "and", "endemic", "only", "in", "Latin", "America", "caused", "by", "the", "flagellate", "protozoa", "Trypanosoma", "cruzi"], "h": {"id": "C0041234", "name": "C0041234#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [8, 9]}}
{"token": ["PO", "caused", "the", "typical", "GI", "effects", "like", "heartburn", "and", "anal/perianal", "burning", "or", "C0231218#ent", "<e1>", "whereas", "the", "C0242896#ent", "<e2>", "caused", "dry", "mouth", "blurred", "vision"], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0242896", "name": "C0242896#ent", "pos": [16, 17]}}
{"token": ["Alterations", "in", "the", "rat", "C0694894#ent", "<e1>", "Tsc2", ")", "are", "responsible", "for", "the", "hereditary", "renal", "carcinomas", "C2699120#ent", "<e2>", ")", "of", "Eker", "rat", "."], "h": {"id": "C0694894", "name": "C0694894#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2699120", "name": "C2699120#ent", "pos": [15, 16]}}
{"token": ["C3813124#ent", "<e1>", "activated", "by", "these", "C0035064#ent", "<e2>", "were", "rendered", "tumoricidal", "and", "destroyed", "syngeneic", ",", "allogeneic", ",", "and", "xenogeneic", "tumor", "targets", "in", "vitro"], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}}
{"token": ["Examination", "of", "C3813124#ent", "<e1>", "by", "electron", "microscopy", "stimulation", "by", "these", "two", "C0035064#ent", "<e2>", "demonstrated", "membrane", "ruffling", "loss", "of", "microvilli", ",", "and", "increased", "vacuolization", "in", "PMA-treated", "cells", "and", "phagocytic", "vacuoles", "bacteria", "in", "HKB-treated", "cells", "."], "h": {"id": "C3813124", "name": "C3813124#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["Nuclear", "transcriptional", "run-off", "experiments", "in", "liver", "cell", "nuclei", "that", "2-allyl-2-isopropylacetamide", "and", "C1327841#ent", "<e1>", "exert", "their", "effect", "by", "C2712370#ent", "<e2>", "the", "rate", "of", "transcription", "of", "the", "5-aminolevulinate", "synthase", "gene"], "h": {"id": "C1327841", "name": "C1327841#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "wild-type", "C1412367#ent", "<e1>", "was", "neuroprotective", "and", "increased", "C1332397#ent", "<e2>", ":", "Bax", "ratio"], "h": {"id": "C1412367", "name": "C1412367#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [10, 11]}}
{"token": ["We", "compare", "our", "case", "and", "the", "10", "previously", "reported", "cases", "and", "discuss", "the", "possible", "association", "of", "complement", "defects", "the", "pathogenesis", "of", "C0024141#ent", "<e1>", "in", "patients", "with", "C0002895#ent", "<e2>", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [26, 27]}}
{"token": ["These", "findings", "indicate", "that", "selection", "for", "C3814801#ent", "<e1>", "sensitivity", "may", "occur", "quite", "rapidly", "and", "that", "changes", "in", "C0026815#ent", "<e2>", "sensitivity", "do", "not", "parallel", "those", "changes", "in", "serotonergic", "sensitivity"], "h": {"id": "C3814801", "name": "C3814801#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026815", "name": "C0026815#ent", "pos": [17, 18]}}
{"token": ["If", "so", ",", "treatment", "of", "mammalian", "organisms", "with", "drugs", "capable", "of", "inducting", "selective", "C0034152#ent", "<e1>", "expression", "in", "vascular", "tissue", "alter", "the", "progression", "of", "C0007222#ent", "<e2>"], "h": {"id": "C0034152", "name": "C0034152#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [23, 24]}}
{"token": ["All", "patients", "complained", "of", "cough", "and", "C0241235#ent", "<e1>", "to", "the", "presence", "of", "C0238132#ent", "<e2>"], "h": {"id": "C0241235", "name": "C0241235#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0238132", "name": "C0238132#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "postmenopausal", "diabetic", "women", "with", "HHNKS", "show", "decreased", "serum", "gonadotrophin", "levels", ",", "and", "severe", "C0020452#ent", "<e1>", "may", "participate", "in", "the", "C0020619#ent", "<e2>", "observed", "in", "HHNKS", "."], "h": {"id": "C0020452", "name": "C0020452#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0020619", "name": "C0020619#ent", "pos": [22, 23]}}
{"token": ["Carrion's", "disease", "typically", "biphasic", "with", "acute", "febrile", "illness", "characterized", "by", "C0004610#ent", "<e1>", "and", "severe", "C0002878#ent", "<e2>", "Oroya", "fever", ",", "followed", "by", "benign", ",", "chronic", "cutaneous", "lesions", "(", "verruga", "peruana", "."], "h": {"id": "C0004610", "name": "C0004610#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [14, 15]}}
{"token": ["Fibrates", ",", "C0086440#ent", "<e1>", "have", "been", "reported", "to", "suppress", "the", "metabolic", "activities", "of", "C0008381#ent", "<e2>", "1A2", "in", "rats", "but", "the", "mechanism", "has", "not", "been", "elucidated", "."], "h": {"id": "C0086440", "name": "C0086440#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008381", "name": "C0008381#ent", "pos": [13, 14]}}
{"token": ["Together", ",", "for", "the", "first", "time", ",", "our", "results", "demonstrate", "synergistic", "neuroprotective", "effects", "lithium", "and", "C1512474#ent", "<e1>", "suggest", "that", "C0244989#ent", "<e2>", "inhibition", "is", "a", "likely", "molecular", "target", "the", "synergistic", "neuroprotection", "."], "h": {"id": "C1512474", "name": "C1512474#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0244989", "name": "C0244989#ent", "pos": [19, 20]}}
{"token": ["A", "case", "of", "the", "hemorrhagic", "gastric", "ulcer", "post-operative", "stomal", "ulcer", "associated", "with", "consumption", "C0005779#ent", "<e1>", "in", "the", "C0012736#ent", "<e2>", "presented", "."], "h": {"id": "C0005779", "name": "C0005779#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012736", "name": "C0012736#ent", "pos": [17, 18]}}
{"token": ["The", "viscoelastic", "and", "adhesive", "properties", "of", "the", "mucus", "gel", "C0304402#ent", "<e1>", "spanned", "the", "ranges", "observed", "for", "bronchial", "secretions", "patients", "with", "C1647218#ent", "<e2>", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [20, 21]}}
{"token": ["Chimeric", "infectious", "bronchitis", "virus", "IBV", ")", "C0242965#ent", "<e1>", "with", "cross-over", "sites", "the", "S1", "gene", "generated", "by", "C0275524#ent", "<e2>", "with", "two", "distinct", "IBV", "strains", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [16, 17]}}
{"token": ["The", "HLE", "cell", "line", "C1417374#ent", "<e1>", "01/04", ",", "which", "was", "transfected", "with", "large", "T-antigen", "of", "C1456377#ent", "<e2>", "was", "cultured", "in", "the", "absence", "of", "serum", "."], "h": {"id": "C1417374", "name": "C1417374#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [15, 16]}}
{"token": ["Their", "active", "forms", "fibric", "acids", "are", "peroxisome", "proliferator-activated", "receptor-alpha", "activators", "but", "no", "direct", "evidence", "has", "been", "demonstrated", "for", "their", "activation", "of", "C3711161#ent", "<e1>", "ABCA1", ")", "in", "relation", "to", "clinically", "used", "C3540783#ent", "<e2>", "."], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3540783", "name": "C3540783#ent", "pos": [30, 31]}}
{"token": ["In", "the", "present", "study", ",", "to", "confirm", "the", "correlation", "between", "thyroid", "autoimmune", "disorders", "C0014378#ent", "<e1>", "we", "examined", "C1955880#ent", "<e2>", "RT", ")", "activity", "in", "thyroid", "tissues", "a", "marker", "of", "retroviral", "infection"], "h": {"id": "C0014378", "name": "C0014378#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [17, 18]}}
{"token": ["Condensation", "of", "C0008546#ent", "<e1>", ",", "nucleoli", "were", "fragmented", "and", "dispersed", "in", "C0005220#ent", "<e2>", "induced", "hepatotoxic", "mice"], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [11, 12]}}
{"token": ["Etodolac", ",", "C0059865#ent", "<e1>", "a", "clinically", "effective", "analgesic", "and", "C0003211#ent", "<e2>", "has", "been", "resolved", "via", "a", "chromatographic", "separation", "its", "diastereoisomeric", "esters", "(-)-borneol", "."], "h": {"id": "C0059865", "name": "C0059865#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [9, 10]}}
{"token": ["On", "the", "other", "hand", ",", "the", "alterations", "of", "TPI", ",", "C1418929#ent", "<e1>", ",", "PGI", ",", "PK", ",", "ADA", ",", "phosphorylase", "kinase", "C0017916#ent", "<e2>", "were", "opposite", "in", "the", "two", "types", "of", "muscle", "."], "h": {"id": "C1418929", "name": "C1418929#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017916", "name": "C0017916#ent", "pos": [21, 22]}}
{"token": ["C0221271#ent", "<e1>", "recorded", "in", "C1413765#ent", "<e2>", "and", "over", "the", "ASSG", "showed", "an", "early", "and", "a", "late", "component"], "h": {"id": "C0221271", "name": "C0221271#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413765", "name": "C1413765#ent", "pos": [4, 5]}}
{"token": ["Overexpression", "of", "either", "the", "CCR4", "or", "DHH1", "genes", "effectively", "suppressed", "phenotypes", "associated", "with", "C1418757#ent", "<e1>", "mutant", "cells", ";", "overexpression", "of", "C1414618#ent", "<e2>", ",", "STM1", ",", "or", "MPT5", "genes", "produced", "only", "partial", "suppression", "."], "h": {"id": "C1418757", "name": "C1418757#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414618", "name": "C1414618#ent", "pos": [20, 21]}}
{"token": ["The", "D1", "receptor", "antagonist", "SCH-23390", "(", "10", "microM", ")", "blocked", "the", "stimulatory", "effect", "of", "dopamine", "on", "C1705846#ent", "<e1>", "but", "the", "C2917388#ent", "<e2>", "sulpiride", "did", "not", "."], "h": {"id": "C1705846", "name": "C1705846#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2917388", "name": "C2917388#ent", "pos": [20, 21]}}
{"token": ["We", "previously", "showed", "that", "C0935989#ent", "<e1>", "mesylate", "synergizes", "with", "gemcitabine", "and", "C0210657#ent", "<e2>", "in", "PDGFRbeta-positive", "mesothelioma", "cells", "."], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0210657", "name": "C0210657#ent", "pos": [11, 12]}}
{"token": ["of", "C0043443#ent", "<e1>", "on", "the", "C0599295#ent", "<e2>", "nasal", "challenge", "a", "double-blind", "cross-over", "trial", "."], "h": {"id": "C0043443", "name": "C0043443#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [5, 6]}}
{"token": ["Different", "factors", "such", "as", "ammonia", ",", "inflammatory", "cytokines", "C0005064#ent", "<e1>", "and", "electrolyte", "imbalances", "may", "precipitate", "or", "aggravate", "C0013604#ent", "<e2>", "thereby", "explaining", "precipitation", "of", "HE", "episodes", "by", "a", "variety", "of", "unrelated", "factors", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [17, 18]}}
{"token": ["The", "flow", "cytometry", "analysis", "that", "the", "C1254351#ent", "<e1>", "alters", "the", "cell", "cycle", "distribution", ",", "but", "no", "sign", "C0011609#ent", "<e2>", "detected", "when", "evaluating", "the", "internucleosomal", "fragmentation", "of", "DNA", "in", "cells", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011609", "name": "C0011609#ent", "pos": [17, 18]}}
{"token": ["Glutathione", "(", "GSH", ")", ",", "thioredoxin", "(", "C1540172#ent", "<e1>", ")", ",", "vitamins", ",", "melatonin", ",", "polyphenols", ",", "trace", "elements", "C1412332#ent", "<e2>", ",", "and", "others", "function", "as", "non-enzymatic", "free", "radicals", "scavengers", "."], "h": {"id": "C1540172", "name": "C1540172#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [19, 20]}}
{"token": ["Calpain", "is", "a", "calcium-activated", "protease", "has", "two", "ubiquitously", "distributed", "mammalian", "isoforms", ",", "namely", "calpain", "1", "calpain", "I", "mu-calpain", "and", "C1436406#ent", "<e1>", ")", "and", "calpain", "2", "calpain", "II", "m-calpain", "and", "C1413112#ent", "<e2>", ")", "."], "h": {"id": "C1436406", "name": "C1436406#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1413112", "name": "C1413112#ent", "pos": [29, 30]}}
{"token": ["Unexpectedly", ",", "C0018440#ent", "<e1>", "not", "detectable", "in", "vesicles", "bearing", "C1420175#ent", "<e2>", "."], "h": {"id": "C0018440", "name": "C0018440#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [9, 10]}}
{"token": ["Animals", "were", "either", "euthyroid", "or", "made", "hyperthyroid", "(", "by", "ingestion", "of", "thyroxine", ")", "or", "C0020676#ent", "<e1>", "(", "by", "ingestion", "of", "C0039957#ent", "<e2>", ")", "during", "involution", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039957", "name": "C0039957#ent", "pos": [20, 21]}}
{"token": ["C1843476#ent", "<e1>", "(", "adaptor", "protein", "Toll-like", "receptor", "and", "Cardif", "(", "adaptor", "protein", "C1539233#ent", "<e2>", "or", "MDA5)-mediated", "signaling", "pathways", "contribute", "rapid", "induction", "of", "interferon-beta", "through", "the", "activation", "of", "interferon", "regulatory", "factor-3", "IRF-3", ")", "."], "h": {"id": "C1843476", "name": "C1843476#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539233", "name": "C1539233#ent", "pos": [12, 13]}}
{"token": ["Our", "data", "suggest", "that", "in", "photoreceptors", "phosphatidylinositol-4,5-bisphosphate", "C0128818#ent", "<e1>", ",", "actin", ",", "and", "C1419407#ent", "<e2>", "act", "in", "concert", "with", "rab8", "to", "regulate", "tethering", "and", "fusion", "of", "RTCs", "."], "h": {"id": "C0128818", "name": "C0128818#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419407", "name": "C1419407#ent", "pos": [13, 14]}}
{"token": ["Inhibitors", "of", "MEK1", "and", "ERK1", ",", "but", "not", "of", "JNK", "or", "C0257535#ent", "<e1>", "abrogated", "TNF", "inhibition", "of", "C1424900#ent", "<e2>", "mRNA", "and", "promoter", "activity"], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1424900", "name": "C1424900#ent", "pos": [17, 18]}}
{"token": ["Chemotherapeutics", "in", "the", "C0215136#ent", "<e1>", "and", "vinca-alkaloid", "classes", "sometimes", "produce", "a", "C0239377#ent", "<e2>", "peripheral", "neuropathy", "which", "there", "is", "no", "validated", "treatment", "."], "h": {"id": "C0215136", "name": "C0215136#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0239377", "name": "C0239377#ent", "pos": [11, 12]}}
{"token": ["Synovial", "fluid", "IC", "both", "RA", "and", "C1290884#ent", "<e1>", "immunoglobulin", "light", "chains", "and", "mu", "and", "C1420192#ent", "<e2>"], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [14, 15]}}
{"token": ["Used", "with", "care", ",", "these", "C0035064#ent", "<e1>", "may", "allow", "effective", "monotherapy", "of", "difficult-to-treat", "C0024116#ent", "<e2>", "with", "the", "added", "benefit", "of", "decreased", "toxicity", "in", "comparison", "with", "the", "more", "traditional", "multiple-drug", "combinations"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024116", "name": "C0024116#ent", "pos": [13, 14]}}
{"token": ["C1333922#ent", "<e1>", "stimulates", "eIF4E-dependent", "export", "of", "cyclin", "D1", "C1417932#ent", "<e2>", "ODC", ")", "mRNAs", "in", "the", "nucleus", ",", "as", "well", "as", "increases", "the", "translation", "efficiency", "of", "ODC", "mRNA", "in", "the", "cytoplasm", "."], "h": {"id": "C1333922", "name": "C1333922#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [8, 9]}}
{"token": ["An", "inhibitor", "of", "C0257535#ent", "<e1>", "SB203580", ",", "protected", "the", "cells", "partially", "from", "C0678133#ent", "<e2>", "and", ",", "unexpectedly", ",", "activated", "ERK", "1/2", "kinases", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0678133", "name": "C0678133#ent", "pos": [12, 13]}}
{"token": ["In", "this", "article", "we", "review", "the", "biological", "plausibility", "and", "clinical", "evidence", "a", "role", "for", "C0360714#ent", "<e1>", "in", "modulating", "two", "C0029896#ent", "<e2>", "of", "ageing", ":", "osteoporosis", "and", "dementia", "(", "including", "Alzheimer's", "disease", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [19, 20]}}
{"token": ["These", "diverse", "properties", "are", "often", "referred", "to", "as", "'", "pleiotropic", "'", "and", "suggest", "that", "C0360714#ent", "<e1>", "may", "affect", "a", "number", "of", "C0029896#ent", "<e2>", "of", "ageing", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [21, 22]}}
{"token": ["Prior", "studies", "have", "suggested", "that", "intravenous", "C0012373#ent", "<e1>", "reduces", "the", "probability", "of", "spontaneous", "conversion", "of", "atrial", "fibrillation", "C0004238#ent", "<e2>", ")", "to", "sinus", "rhythm", "the", "electrophysiology", "laboratory", "and", "in", "patients", "with", "postoperative", "C0004238#ent", "<e2>", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0004238", "name": "C0004238#ent", "pos": [17, 18]}}
{"token": ["The", "C0078792#ent", "<e1>", "-", "2", "gene", "belongs", "to", "the", "EPF", "C1335597#ent", "<e2>", "petunia", "(", "Petunia", "hybrida", ",", "which", "encodes", "proteins", "with", "TFIIIA-type", "zinc-finger", "DNA-binding", "motifs", "."], "h": {"id": "C0078792", "name": "C0078792#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335597", "name": "C1335597#ent", "pos": [10, 11]}}
{"token": ["TNFalpha", "activation", "of", "the", "NF-kappaB", "pathway", "associated", "with", "inducible", "binding", "of", "C3812805#ent", "<e1>", "to", "TRAF2", "and", "both", "IKKalpha", "and", "C1442489#ent", "<e2>", "."], "h": {"id": "C3812805", "name": "C3812805#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1442489", "name": "C1442489#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "our", "studies", "suggests", "that", "C3812805#ent", "<e1>", "acts", "as", "an", "upstream", "activating", "kinase", "C1442489#ent", "<e2>", "and", "JNK", ",", "but", "not", "IKKalpha", ",", "revealing", "an", "unexpectedly", "specific", "role", "of", "C3812805#ent", "<e1>", "in", "inflammatory", "signaling", "pathways"], "h": {"id": "C3812805", "name": "C3812805#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1442489", "name": "C1442489#ent", "pos": [14, 15]}}
{"token": ["5", "-", "8", "%", "of", "C0003872#ent", "<e1>", "patients", "develop", "C0003864#ent", "<e2>", "."], "h": {"id": "C0003872", "name": "C0003872#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [9, 10]}}
{"token": ["After", "bile", "duct", "ligation", ",", "C0057041#ent", "<e1>", "increased", "to", "760", "U/l", "after", "1", "day", "in", "rats", "C0342895#ent", "<e2>", "a", "control", "diet"], "h": {"id": "C0057041", "name": "C0057041#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [16, 17]}}
{"token": ["The", "optimal", "temperatures", "for", "C1705287#ent", "<e1>", "and", "AmyC", "activities", "on", "soluble", "C0054259#ent", "<e2>", "were", "80", "degrees", "C", "and", "70", "degrees", "C", ",", "respectively", "."], "h": {"id": "C1705287", "name": "C1705287#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [11, 12]}}
{"token": ["Erythropoietin", "(", "C1366564#ent", "<e1>", ")", "mRNA", "levels", "were", "measured", "by", "ribonuclease", "(", "C0035541#ent", "<e2>", ")", "protection", "in", "organs", "from", "unstimulated", "rats", "and", "from", "animals", "after", "normobaric", "hypoxia", "or", "hemorrhagic", "anemia"], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [12, 13]}}
{"token": ["Erythropoietin", "(", "C1366564#ent", "<e1>", ")", "mRNA", "levels", "were", "measured", "by", "C0035541#ent", "<e2>", "(", "RNase", ")", "protection", "in", "organs", "from", "unstimulated", "rats", "and", "from", "animals", "after", "normobaric", "hypoxia", "or", "hemorrhagic", "anemia"], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [10, 11]}}
{"token": ["C1366564#ent", "<e1>", "(", "EPO", ")", "mRNA", "levels", "were", "measured", "by", "C0035541#ent", "<e2>", "(", "RNase", ")", "protection", "in", "organs", "from", "unstimulated", "rats", "and", "from", "animals", "after", "normobaric", "hypoxia", "or", "hemorrhagic", "anemia"], "h": {"id": "C1366564", "name": "C1366564#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035541", "name": "C0035541#ent", "pos": [10, 11]}}
{"token": ["The", "tolerance", "observed", "with", "C0023992#ent", "<e1>", "was", "significantly", "prevented", "by", "C0010592#ent", "<e2>", "(", "30", "mg/kg", ",", "i.p", ".", ")", ","], "h": {"id": "C0023992", "name": "C0023992#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [10, 11]}}
{"token": ["Three", "subunits", "of", "TFIIH", ",", "cdk7", ",", "C0258442#ent", "<e1>", "MAT1", ",", "form", "a", "ternary", "complex", "C0246305#ent", "<e2>", "CAK", ")", ",", "found", "either", "on", "its", "own", "or", "as", "part", "of", "TFIIH", "."], "h": {"id": "C0258442", "name": "C0258442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0246305", "name": "C0246305#ent", "pos": [15, 16]}}
{"token": ["Some", "enzymes", "associated", "with", "C0851358#ent", "<e1>", "such", "as", "acid", "phosphatase", "alkaline", "phosphatase", "nitrate", "reductase", "mannitol", "dehydrogenase", "C1421114#ent", "<e2>", ",", "in", "the", "roots", ",", "stems", "and", "leaves", "of", "plant", "were", "obviously", "inhibited", "by", "the", "artificial", "acid", "rain", "Al", "."], "h": {"id": "C0851358", "name": "C0851358#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [16, 17]}}
{"token": ["After", "initial", "trials", "of", "conventional", "C0026256#ent", "<e1>", "pacing", "in", "C0007193#ent", "<e2>", "the", "concept", "of", "multisite", "stimulation", "introduced", "in", "1994", "."], "h": {"id": "C0026256", "name": "C0026256#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007193", "name": "C0007193#ent", "pos": [9, 10]}}
{"token": ["Duration", "of", "antibiotic", "therapy", "typically", "1", "to", "2", "weeks", "for", "cystitis", ",", "4", "weeks", "for", "C1720795#ent", "<e1>", "and", "6", "to", "12", "weeks", "for", "C1720797#ent", "<e2>"], "h": {"id": "C1720795", "name": "C1720795#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1720797", "name": "C1720797#ent", "pos": [23, 24]}}
{"token": ["The", "TAPR", "locus", "containing", "the", "TIM", "C1517488#ent", "<e1>", "implicated", "in", "the", "development", "of", "atopic", "inflammation", "mouse", ",", "and", "C1425141#ent", "<e2>", "allelic", "variation", "has", "been", "associated", "with", "incidence", "of", "atopy", "in", "human", "patient", "populations", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1425141", "name": "C1425141#ent", "pos": [18, 19]}}
{"token": ["In", "humans", ",", "patients", "with", "hypocalcemic", "C2363065#ent", "<e1>", "type", "II", "high", "circulating", "C3537249#ent", "<e2>", "levels", "and", "C3537249#ent", "<e2>", "resistance", "due", "to", "expression", "of", "a", "dysfunctional", "vitamin", "D", "receptor", "(", "VDR", ")", "."], "h": {"id": "C2363065", "name": "C2363065#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3537249", "name": "C3537249#ent", "pos": [12, 13]}}
{"token": ["Purification", "of", "the", "C.", "glutamicum", "C2975630#ent", "<e1>", "concentrated", "supernatants", ",", "SDS-PAGE", "and", "matrix-assisted", "laser", "desorption/ionization", "time-of-flight", "mass", "spectrometry", "modified", "C1333208#ent", "<e2>", "variants", "with", "increased", "or", "reduced", "mobility", "when", "compared", "with", "the", "calculated", "size", "of", "C1333208#ent", "<e2>", "."], "h": {"id": "C2975630", "name": "C2975630#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333208", "name": "C1333208#ent", "pos": [19, 20]}}
{"token": ["C1455838#ent", "<e1>", "found", "to", "be", "C1512488#ent", "<e2>", "to", "human", "cholesteryl", "ester", "transfer", "protein", "human", "lipopolysaccharide-binding", "protein", "and", "human", "neutrophil", "bactericidal", "permeability", "increasing", "protein", "(", "20", ",", "24", ",", "and", "26", "%", "identity", ",", "respectively", ")", "."], "h": {"id": "C1455838", "name": "C1455838#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [5, 6]}}
{"token": ["This", "may", "encourage", "the", "use", "of", "C1882065#ent", "<e1>", "reduce", "bone", "resorption", "the", "therapy", "of", "demineralizing", "C0005944#ent", "<e2>"], "h": {"id": "C1882065", "name": "C1882065#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005944", "name": "C0005944#ent", "pos": [15, 16]}}
{"token": ["We", "report", "an", "unusual", "case", "of", "a", "young", "woman", "with", "C1258104#ent", "<e1>", "presented", "with", "proximal", "muscle", "weakness", "dyspnea", ",", "weight", "loss", "and", "C2004489#ent", "<e2>"], "h": {"id": "C1258104", "name": "C1258104#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2004489", "name": "C2004489#ent", "pos": [22, 23]}}
{"token": ["Most", "strikingly", ",", "Th2", "adjuvants", "enhanced", "the", "C3815527#ent", "<e1>", "expression", "on", "human", "C1456795#ent", "<e2>", "but", "did", "not", "induce", "Delta4", "expression", ",", "which", "was", "induced", "by", "a", "Th1", "adjuvant", "."], "h": {"id": "C3815527", "name": "C3815527#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [12, 13]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "phosphoglucose", "isomerase", "fruI", ")", "and", "C0060764#ent", "<e2>", "(", "fruK", ")", "of", "Lactobacillus", "fermentum", "NRRL-B-1932", "were", "sequenced", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0060764", "name": "C0060764#ent", "pos": [9, 10]}}
{"token": ["DD", ",", "C2985156#ent", "<e1>", ",", "and", "CASP", "C0175168#ent", "<e2>", "six", "helices", "along", "their", "sequences", ";", "ASC2", "presents", "5", "well-defined", "helices", "due", "to", "long", "distance", "restraints", "."], "h": {"id": "C2985156", "name": "C2985156#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [7, 8]}}
{"token": ["Magnetic", "resonance", "imaging", "MRI", ")", ",", "(18F)-fluorodeoxyglucose", "positron", "emission", "tomography", "(", "C1822794#ent", "<e1>", "PET", ")", ",", "urine", "serum", "and", "cerebrospinal", "fluid", "C3889436#ent", "<e2>", ")", "biomarkers", ",", "as", "well", "as", "clinical/psychometric", "assessments", "are", "acquired", "at", "multiple", "time", "points"], "h": {"id": "C1822794", "name": "C1822794#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [21, 22]}}
{"token": ["We", "examined", "roles", "of", "cytosolic", "hsp70", "family", "members", "import", "of", "ornithine", "transcarbamylase", "precursor", "C0268542#ent", "<e1>", ")", "into", "rat", "C0023899#ent", "<e2>", "mitochondria", ",", "using", "an", "in", "vitro", "import", "system", "antibodies", "against", "hsp70", "."], "h": {"id": "C0268542", "name": "C0268542#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}}
{"token": ["Although", "Nup50-null", "mouse", "embryo", "fibroblasts", "exhibited", "no", "defects", "in", "either", "cell", "cycle", "control", "C1332737#ent", "<e1>", "regulation", ",", "C1417894#ent", "<e2>", "deletion", "was", "associated", "with", "abnormalities", "in", "C1332737#ent", "<e1>", "expression", "and", "cell", "proliferation", "the", "developing", "neuroepithelium", "."], "h": {"id": "C1417894", "name": "C1417894#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [13, 14]}}
{"token": ["Major", "patterns", "of", "pulmonary", "disease", "associated", "with", "inflammatory", "bowel", "disease", "IBD", ")", "are", "pleuritis", ",", "C0699949#ent", "<e1>", "interstitial", "lung", "disease", "necrobiotic", "nodules", ",", "C0034068#ent", "<e2>", "thromboembolic", "disease", "vasculitis", ",", "granulomatous", "lung", "disease", "etc", "."], "h": {"id": "C0699949", "name": "C0699949#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0034068", "name": "C0034068#ent", "pos": [23, 24]}}
{"token": ["The", "chronic", "state", "of", "hypovolemia", "hypotension", ",", "and", "hypokalemia", "found", "in", "Bartter's", "syndrome", "been", "shown", "to", "lead", "to", "a", "C0403592#ent", "<e1>", "which", "then", "can", "progress", "toward", "C2316810#ent", "<e2>", "dialysis", "."], "h": {"id": "C0403592", "name": "C0403592#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [26, 27]}}
{"token": ["Of", "6", "C0242911#ent", "<e1>", "tested", ",", "quinine", "and", "C0034403#ent", "<e2>", "were", "the", "most", "effective", "inhibitors", "and", "mefloquine", "was", "the", "least", "effective", "."], "h": {"id": "C0242911", "name": "C0242911#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034403", "name": "C0034403#ent", "pos": [8, 9]}}
{"token": ["To", "unravel", "the", "biological", "significance", "of", "the", "alternative", "splicing", "of", "C1452577#ent", "<e1>", "expression", "of", "the", "C1333242#ent", "<e2>", "various", "tissues", "and", "developmental", "stages", "investigated", "in", "postnatal", "mice"], "h": {"id": "C1452577", "name": "C1452577#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333242", "name": "C1333242#ent", "pos": [15, 16]}}
{"token": ["Here", "we", "have", "determined", "the", "crystal", "structure", "the", "DH", "and", "PH", "domains", "of", "the", "T-lymphoma", "invasion", "metastasis", "factor", "1", "C0812248#ent", "<e1>", ")", "protein", "in", "complex", "with", "its", "cognate", "C0174045#ent", "<e2>", "Rac1", "."], "h": {"id": "C0812248", "name": "C0812248#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0174045", "name": "C0174045#ent", "pos": [28, 29]}}
{"token": ["Seem", "(", "Japanese", "angelica", "tree", ")", "have", "long", "been", "used", "as", "a", "C3543842#ent", "<e1>", ",", "antiarthritic", "and", "C0935929#ent", "<e2>", "China", "and", "Japan", "."], "h": {"id": "C3543842", "name": "C3543842#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [17, 18]}}
{"token": ["Activated", "keratinocytes", "express", "a", "specific", "pair", "of", "keratin", "proteins", "K6", "and", "C3889435#ent", "<e1>", ",", "distinct", "from", "the", "C0010803#ent", "<e2>", "in", "the", "healthy", "epidermis"], "h": {"id": "C3889435", "name": "C3889435#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [17, 18]}}
{"token": ["We", "previously", "characterized", "the", "cystinosis", "gene", "C1413803#ent", "<e1>", ",", "and", "identified", "pathogenic", "mutations", "patients", "with", "infantile", "C0015624#ent", "<e2>", "including", "a", "common", ",", "approximately", "65", "kb", "deletion", "which", "encompasses", "exons", "1-10"], "h": {"id": "C1413803", "name": "C1413803#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [16, 17]}}
{"token": ["She", "remained", "in", "coma", "with", "frequent", "seizures", "for", "1", "wk", ",", "with", "persisting", "severe", "thrombocytopenia", "and", "C0002878#ent", "<e1>", "despite", "treatment", "with", "C0032950#ent", "<e2>", ",", "plasma", "exchange", "fresh", "frozen", "plasma", "sulphinpyrazone", "and", "dipyridamole", "."], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [16, 17]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [21, 22]}}
{"token": ["The", "partial", "agonist", "Sar1-Ala8-angiotensin", "II", "(", "C4283882#ent", "<e1>", ")", "increased", "blood", "pressure", "blocked", "the", "C0237795#ent", "<e2>", "response", "to", "subsequent", "AII", "treatment", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [14, 15]}}
{"token": ["Zimelidine", ",", "trazodone", ",", "C0009010#ent", "<e1>", ",", "doxepin", ",", "and", "C0042665#ent", "<e2>", "(", "1", "mumol/l", "each", ")", "enhanced", "the", "electrically-induced", "3H", "overflow", "by", "20", "-", "44", "%", "."], "h": {"id": "C0009010", "name": "C0009010#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042665", "name": "C0042665#ent", "pos": [10, 11]}}
{"token": ["Inhibition", "of", "Akt", "activation", "with", "C0251991#ent", "<e1>", "abolished", ",", "and", "inhibition", "of", "JNK", "activation", "with", "C0968383#ent", "<e2>", "enhanced", "the", "cardioprotection", "by", "insulin", ",", "respectively", "."], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0968383", "name": "C0968383#ent", "pos": [15, 16]}}
{"token": ["Some", "of", "the", "genes", "that", "play", "a", "crucial", "role", "in", "germ", "cell", "are", "Steel", ",", "c-Kit", ",", "VASA", ",", "C1413914#ent", "<e1>", ",", "fragilis", ",", "miwi", ",", "mili", ",", "mil1", "and", "C0879590#ent", "<e2>", "."], "h": {"id": "C1413914", "name": "C1413914#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [30, 31]}}
{"token": ["The", "distribution", "of", "C1423536#ent", "<e1>", "that", "of", "a", "mitochondrial", "marker", "C0027293#ent", "<e2>", "."], "h": {"id": "C1423536", "name": "C1423536#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027293", "name": "C0027293#ent", "pos": [10, 11]}}
{"token": ["Our", "data", "do", "not", "support", "the", "hypothesis", "that", "C0022860#ent", "<e1>", ",", "at", "effective", "C0042420#ent", "<e2>", "inhibits", "platelet", "aggregation", "mild-to-moderate", "hypertensive", "patients", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042420", "name": "C0042420#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "after", "removal", "of", "extracellular", "Ca2", "+", ",", "C0051844#ent", "<e1>", "II-induced", "as", "well", "as", "platelet-derived", "growth", "C1366571#ent", "<e2>", "Ca2", "+", "release", "exhibited", "Cl-", "dependency", "."], "h": {"id": "C0051844", "name": "C0051844#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [18, 19]}}
{"token": ["We", "found", "that", "some", "selected", "genes", "(", "long-chain", "fatty-acid-CoA", "ligase", "FACL1", ")", ",", "carnitine", "palmitoyltransferase", "1A", "CPT1A", ")", ",", "adipose", "differentiation-related", "protein", "C3889465#ent", "<e1>", ")", "and", "aquaporin", "3", "AQP3", ")", ")", "were", "down-regulated", "by", "C2984537#ent", "<e2>", "siRNA", "."], "h": {"id": "C3889465", "name": "C3889465#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2984537", "name": "C2984537#ent", "pos": [34, 35]}}
{"token": ["The", "results", "of", "these", "studies", "provide", "structural", "insight", "into", "how", "the", "C0086903#ent", "<e1>", "with", "the", "C0388250#ent", "<e2>", "."], "h": {"id": "C0086903", "name": "C0086903#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0388250", "name": "C0388250#ent", "pos": [15, 16]}}
{"token": ["Discovery", "of", "the", "novel", "fusion", "gene", "C1540912#ent", "<e1>", "FIPILI-PFGFRA", ",", "whose", "product", "is", "an", "C0939537#ent", "<e2>", "sensitive", "protein", "kinase", "permitted", "to", "treat", "successfully", "this", "event", "."], "h": {"id": "C1540912", "name": "C1540912#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0939537", "name": "C0939537#ent", "pos": [14, 15]}}
{"token": ["Similarly", ",", "multimerized", "NF-kappaB", "sites", "nucleosome", "binding", "C2986464#ent", "<e1>", "and", "reduced", "the", "stimulatory", "effect", "of", "C1337050#ent", "<e2>", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337050", "name": "C1337050#ent", "pos": [15, 16]}}
{"token": ["Second", ",", "the", "NHR", "preference", "for", "C1334870#ent", "<e1>", "or", "SMRT", "is", "due", "to", "differences", "in", "C4284308#ent", "<e2>", "but", "not", "CoRNR2", "."], "h": {"id": "C1334870", "name": "C1334870#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4284308", "name": "C4284308#ent", "pos": [15, 16]}}
{"token": ["Recently", ",", "mutations", "in", "the", "human", "mi", "gene", "(", "MITF", ")", "were", "found", "in", "patients", "with", "Waardenburg", "Syndrome", "type", "2", "C1860339#ent", "<e1>", ")", ",", "a", "dominantly", "inherited", "C0039082#ent", "<e2>", "associated", "with", "hearing", "loss", "pigmentary", "disturbances", "."], "h": {"id": "C1860339", "name": "C1860339#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "glutamate", "tonically", "activates", "the", "CVLM", "to", "reduce", "C2984121#ent", "<e1>", "independent", "of", "the", "C1417869#ent", "<e2>", ",", "and", "this", "excitatory", "input", "appears", "to", "be", "affected", "by", "the", "strength", "of", "central", "respiratory", "."], "h": {"id": "C2984121", "name": "C2984121#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [14, 15]}}
{"token": ["To", "determine", "the", "efficacy", "of", "topically", "applied", "C0038633#ent", "<e1>", "suspension", "in", "the", "treatment", "of", "oral", "and", "genital", "ulceration", "C0004943#ent", "<e2>"], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004943", "name": "C0004943#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "this", "study", "finds", "that", "C1426677#ent", "<e1>", "promotes", "the", "expression", "of", "Rta", "and", "Zta", "from", "C0149678#ent", "<e2>", ",", "indicating", "that", "C1426677#ent", "<e1>", "participates", "C0149678#ent", "<e2>", "lytic", "activation", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1426677", "name": "C1426677#ent", "pos": [6, 7]}}
{"token": ["The", "impact", "of", "C1415620#ent", "<e1>", "deletion", "comparing", "C1263960#ent", "<e2>", "C1415620#ent", "<e1>", "(", "+", "/+", ")", "mice", "and", "C1415620#ent", "<e1>", "knockout", "(", "-/-", ")", "mice", "was", "examined", "."], "h": {"id": "C1415620", "name": "C1415620#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1263960", "name": "C1263960#ent", "pos": [7, 8]}}
{"token": ["The", "cause", "of", "lung", "bleeding", "C3495801#ent", "<e1>", "was", "characterized", "by", "C0042384#ent", "<e2>", "haemic", "and", "tissue", "eosinophilia", "lymph", "node", "granulomatosis", "diffuse", "glomerulonephritis"], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [10, 11]}}
{"token": ["Our", "study", "shows", "a", "generalized", "increase", "in", "innate", "immune", "responses", "associated", "with", "progression", "of", "C0003850#ent", "<e1>", "and", "a", "less", "inflammatory", "and", "less", "C1425257#ent", "<e2>", "plaque", "phenotype", "during", "aging", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1425257", "name": "C1425257#ent", "pos": [22, 23]}}
{"token": ["Two", "of", "the", "strains", "had", "C0017868#ent", "<e1>", "with", "glucose", "teichoic", "acids", "another", "possessed", "C0017868#ent", "<e1>", ",", "glucose", ",", "glucosamine", "and", "C0001056#ent", "<e1>"], "h": {"id": "C0017868", "name": "C0017868#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001056", "name": "C0001056#ent", "pos": [20, 21]}}
{"token": ["We", "studied", "the", "release", "of", "the", "C1822653#ent", "<e1>", "normal", "subjects", "patients", "with", "C0001206#ent", "<e2>", "."], "h": {"id": "C1822653", "name": "C1822653#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [12, 13]}}
{"token": ["This", "domain", "is", "found", "in", "the", "C0017337#ent", "<e1>", "encoding", "the", "archaeal", "tRNA", "C0075033#ent", "<e2>", "H.", "volcanii", "and", "in", "other", "Archaea", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0075033", "name": "C0075033#ent", "pos": [12, 13]}}
{"token": ["With", "respect", "to", "bone", "cell", "differentiation", "C0758539#ent", "<e1>", "genistein", "each", "significantly", "increased", "basal", "C3812647#ent", "<e2>", "specific", "activity", "and", "collagen", "synthesis", "in", "human", "bone", "cells"], "h": {"id": "C0758539", "name": "C0758539#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3812647", "name": "C3812647#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "C1333229#ent", "<e1>", "and", "RPB2", ",", "the", "C0017337#ent", "<e2>", "encoding", "the", "two", "largest", "subunits", "of", "RNAP", "II", "were", "identified", "as", "suppressors", "of", "ssu72", "-", "2", "."], "h": {"id": "C1333229", "name": "C1333229#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["The", "C1418276#ent", "<e1>", "C1335193#ent", "<e2>", "involved", "in", "C1418276#ent", "<e1>", "gene", "autoregulation", "binding", "to", "its", "enhancer", "."], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418276", "name": "C1418276#ent", "pos": [1, 2]}}
{"token": ["We", "have", "studied", "the", "effect", "of", "structural", "changes", "the", "C1335193#ent", "<e1>", "the", "function", "of", "C1418276#ent", "<e2>", "mediated", "through", "its", "homeodomain", "."], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418276", "name": "C1418276#ent", "pos": [14, 15]}}
{"token": ["Coexpression", "of", "the", "mouse", "C3538853#ent", "<e1>", "in", "Xenopus", "oocytes", "the", "three", "C0599220#ent", "<e2>", "of", "the", "epithelial", "Na+", "channel", "results", "in", "a", "significantly", "enhanced", "Na+", "current", "."], "h": {"id": "C3538853", "name": "C3538853#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [11, 12]}}
{"token": ["In", "this", "case", "report", "we", "describe", "a", "case", "of", "C0023241#ent", "<e1>", "as", "altered", "mental", "status", "high", "fever", "and", "rhabdomyolysis", "with", "C3854173#ent", "<e2>"], "h": {"id": "C0023241", "name": "C0023241#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [20, 21]}}
{"token": ["C0242896#ent", "<e1>", "amantadine", ",", "selegiline", ",", "and", "C0178601#ent", "<e2>", "be", "reduced", "or", "discontinued", ",", "provided", "that", "the", "patient", "can", "tolerate", "changes", "in", "motor", "symptoms", "to", "such", "reductions", "."], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0178601", "name": "C0178601#ent", "pos": [7, 8]}}
{"token": ["Drugs", "currently", "used", "for", "palliative", "therapy", "into", "three", "categories", ":", "C0242896#ent", "<e1>", "dopamine", "precursors", "levodopa", "combined", "with", "extracerebral", "decarboxylase", "inhibitors", "and", "C0178601#ent", "<e2>"], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0178601", "name": "C0178601#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "C0129975#ent", "<e1>", "mesylate", "reduces", "the", "UAE", "probably", "through", "an", "inhibitory", "effect", "on", "initial", "diabetic", "renal", "hypertrophy", "that", "C0129975#ent", "<e1>", "mesylate", "is", "available", "for", "C1442864#ent", "<e1>"], "h": {"id": "C0129975", "name": "C0129975#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [27, 28]}}
{"token": ["Three", "cases", "of", "C1449563#ent", "<e1>", "complicating", "the", "acquired", "C0021051#ent", "<e2>", "AIDS", ")", "are", "reported", "."], "h": {"id": "C1449563", "name": "C1449563#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [8, 9]}}
{"token": ["TA-induced", "cell", "death", "was", "attenuated", "by", "inhibition", "of", "C0600388#ent", "<e1>", "ERK", ")", "1/2", "with", "C0755562#ent", "<e2>", "and", "inhibition", "of", "p38(MAPK", ")", "with", "SB203580", "."], "h": {"id": "C0600388", "name": "C0600388#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [14, 15]}}
{"token": ["The", "newly", "discovered", "brain", "messenger", "10,17S-docosatriene", "potently", "inhibited", "leukocyte", "infiltration", "NFkappaB", ",", "and", "C0387583#ent", "<e1>", "induction", "in", "experimental", "stroke", "elicited", "C0242912#ent", "<e2>", "."], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [20, 21]}}
{"token": ["Analysis", "of", "the", "precipitates", "obtained", "directly", "from", "the", "sera", "by", "addition", "of", "4", "%", "C0032483#ent", "<e1>", "either", "a", "mixture", "of", "IgG", "and", "C1706005#ent", "<e2>", "or", "C1706005#ent", "<e2>", "alone", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [22, 23]}}
{"token": ["Factors", "regulating", "tyrosine", "hydroxylase", "TH", ")", "C0812327#ent", "<e1>", "of", "major", "importance", "in", "the", "studies", "of", "malignant", "and", "C1456654#ent", "<e2>", "catecholamine-synthesizing", "tissues", "."], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1456654", "name": "C1456654#ent", "pos": [17, 18]}}
{"token": ["A", "group", "of", "561", "consecutive", "patients", "with", "proven", "symptomatic", "peripheral", "or", "C0007774#ent", "<e1>", "attending", "a", "vascular", "clinic", "screened", "for", "abdominal", "aortic", "aneurysm", "C0162871#ent", "<e2>", ")", "using", "B-mode", "ultrasonography"], "h": {"id": "C0007774", "name": "C0007774#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0162871", "name": "C0162871#ent", "pos": [22, 23]}}
{"token": ["Hypoglycaemic", "response", "C0015840#ent", "<e1>", "was", "not", "changed", "whereas", "the", "C0020459#ent", "<e2>", "response", "to", "C0015840#ent", "<e1>", "was", "attenuated", "by", "dietary", "RAC", "."], "h": {"id": "C0015840", "name": "C0015840#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020459", "name": "C0020459#ent", "pos": [9, 10]}}
{"token": ["Serum", "procarboxypeptidase", "A", "activated", "by", "trypsin", ",", "chymotrypsin", ",", "plasmin", ",", "subtilisin", ",", "or", "C1522670#ent", "<e1>", "but", "not", "by", "thrombin", "or", "C1418973#ent", "<e2>", "."], "h": {"id": "C1522670", "name": "C1522670#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418973", "name": "C1418973#ent", "pos": [21, 22]}}
{"token": ["The", "mechanism", "responsible", "for", "this", "blunted", "response", "has", "been", "postulated", "to", "be", "activation", "of", "the", "renin-angiotensin", "system", "associated", "potent", "antinatriuretic", "effects", "and/or", "the", "reduction", "in", "renal", "perfusion", "pressure", "C2699119#ent", "<e1>", ")", "characteristic", "of", "C0018801#ent", "<e2>"], "h": {"id": "C2699119", "name": "C2699119#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [33, 34]}}
{"token": ["The", "results", "suggest", "that", "the", "bioactivation", "of", "C0014027#ent", "<e1>", "to", "enalaprilat", "is", "considerably", "impaired", "in", "patients", "with", "C0023890#ent", "<e2>", "but", "that", "the", "pharmacodynamic", "effects", "not", "appear", "to", "be", "blunted", "in", "those", "patients", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [17, 18]}}
{"token": ["The", "purified", "glycolytic", "C3540772#ent", "<e1>", "specifically", "bound", "the", "23-", "and", "29-kDa", "C0752092#ent", "<e2>", "both", "denaturing", "and", "nondenaturing", "conditions", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752092", "name": "C0752092#ent", "pos": [11, 12]}}
{"token": ["Two", "C0597979#ent", "<e1>", "with", "apparent", "C1425021#ent", "<e2>", "of", "5.4", "and", "6.4", "were", "identified", ";", "the", "beta-lactamase", "with", "a", "pI", "of", "6.4", "was", "transferred", "by", "conjugation", "and", "associated", "with", "40-kb", "plasmid", "."], "h": {"id": "C0597979", "name": "C0597979#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1425021", "name": "C1425021#ent", "pos": [5, 6]}}
{"token": ["It", "has", "been", "stated", "that", "incidence", "of", "hypertension", ",", "C0020443#ent", "<e1>", ",", "overweight", "and", "obesity", "in", "men", "and", "C0041983#ent", "<e2>", "in", "both", "sexes", "decreased", "with", "hardness", "of", "the", "work", "."], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041983", "name": "C0041983#ent", "pos": [18, 19]}}
{"token": ["In", "NIH/3T3", "cells", "transfected", "with", "gpClC-3", "(", "the", "gene", "encoding", "C3809768#ent", "<e1>", ",", "vol", ")", ",", "8-Br-cAMP", "consistently", "inhibited", "C3809768#ent", "<e1>", ",", "C1413452#ent", "<e1>", "."], "h": {"id": "C3809768", "name": "C3809768#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413452", "name": "C1413452#ent", "pos": [22, 23]}}
{"token": ["Recent", "findings", "show", "that", "Bora", ",", "a", "G(2)-M", "expressed", "protein", ",", "facilitates", "C1335227#ent", "<e1>", "activation", "by", "the", "C1420466#ent", "<e2>", "G(2", ")", "."], "h": {"id": "C1335227", "name": "C1335227#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420466", "name": "C1420466#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "FRD1", "showed", "increased", "C3809768#ent", "<e1>", "activity", "and", "expression", "of", "an", "aceA", ":", ":", "C1421976#ent", "<e2>", "fusion", "compared", "to", "PAO1", "."], "h": {"id": "C3809768", "name": "C3809768#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [15, 16]}}
{"token": ["Chymotrypsin", "dissects", "the", "C1305923#ent", "<e1>", "Phe762", "and", "Ser763", ",", "thereby", "retaining", "the", "C0001942#ent", "<e2>", "activity", "on", "the", "NH2-terminal", "core", ",", "but", "destroying", "all", "other", "activities", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [12, 13]}}
{"token": ["To", "test", "whether", "C0072074#ent", "<e1>", "transcription", "is", "applicable", "to", "C0036690#ent", "<e2>", "diagnosis", ",", "we", "analyzed", "whole", "blood", "a", "microarray", "containing", "probes", "for", "340", "genes", "relevant", "to", "inflammation", "."], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [9, 10]}}
{"token": ["XAP2", "is", "also", "able", "to", "interact", "with", "C3273507#ent", "<e1>", "complexes", "in", "the", "absence", "of", "the", "C0596123#ent", "<e2>", ",", "and", "C-terminal", "sequences", "XAP2", "are", "required", "for", "this", "interaction", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0596123", "name": "C0596123#ent", "pos": [15, 16]}}
{"token": ["End", "stage", "renal", "disease", "ESRD", ")", "is", "an", "important", "and", "costly", "complication", "of", "C0011847#ent", "<e1>", ",", "hypertension", ",", "and", "C0543793#ent", "<e2>"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0543793", "name": "C0543793#ent", "pos": [19, 20]}}
{"token": ["shaggy", "is", "also", "required", "for", "the", "lateral", "signal", "encodes", "C0072402#ent", "<e1>", "homology", "to", "the", "glycogen", "synthase", "kinase-3", "C0244989#ent", "<e2>", ")", "enzymes", "that", "act", "in", "signal", "transduction", "pathways", "vertebrates", "."], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [9, 10]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0244989", "name": "C0244989#ent", "pos": [17, 18]}}
{"token": ["5-HT3", "receptor", "antagonists", "well", "tolerated", "with", "the", "most", "frequently", "reported", "adverse", "effects", "C0018681#ent", "<e1>", ",", "constipation", ",", "dizziness", ",", "C0041834#ent", "<e2>", ",", "and", "gastrointestinal", "disturbances", "as", "abdominal", "pain", "constipation", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [19, 20]}}
{"token": ["Multiple", "spatially", "disparate", "splice", "sites", "C1419502#ent", "<e1>", "can", "be", "used", ",", "calling", "into", "question", "both", "the", "C1539479#ent", "<e2>", "of", "its", "pairing", "to", "the", "branch", "site", "the", "details", "of", "its", "role", "in", "splicing", "catalysis"], "h": {"id": "C1419502", "name": "C1419502#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [16, 17]}}
{"token": ["Regulated", "secretion", "of", "this", "C1333196#ent", "<e1>", "was", "induced", "by", "0.5", "mM", "ATP", "and", "treatment", "with", "C1367721#ent", "<e2>", "EGF", ")", "and", "nerve", "growth", "factor", "NGF", ")", "."], "h": {"id": "C1333196", "name": "C1333196#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [15, 16]}}
{"token": ["We", "showed", "previously", "that", "exogenous", "overexpression", "of", "C3G", "a", "guanine", "nucleotide", "releasing", "factor", "GEF", ")", "for", "C3814146#ent", "<e1>", "and", "R-Ras", "proteins", "blocks", "the", "focus-forming", "activity", "cotransfected", ",", "activated", ",", "C1705597#ent", "<e2>", ",", "ras", "and", "v-raf", "oncogenes", "NIH", "3T3", "cells"], "h": {"id": "C3814146", "name": "C3814146#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705597", "name": "C1705597#ent", "pos": [29, 30]}}
{"token": ["Because", "most", "C0524947#ent", "<e1>", "only", "have", "genes", "for", "FK506-binding", "proteins", "FKBPs", ")", "as", "a", "C1414619#ent", "<e2>", ",", "it", "has", "been", "unclear", "whether", "H.", "cutirubrum", "has", "an", "FKBP-type", "PPIase", "or", "not", "."], "h": {"id": "C0524947", "name": "C0524947#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414619", "name": "C1414619#ent", "pos": [14, 15]}}
{"token": ["The", "neurological", "symptoms", "signs", "were", "headaches", ",", "right", "quadrant", "hemianopia", ",", "dyslexia", "without", "agraphia", ",", "motor", "aphasia", "numbness", "in", "and", "C3714552#ent", "<e1>", "of", "the", "right", "upper", "extremity", "C0155300#ent", "<e2>", "and", "coma", "."], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0155300", "name": "C0155300#ent", "pos": [27, 28]}}
{"token": ["Oxynticopeptic", "cells", "tissues", "pretreated", "with", "C0028978#ent", "<e1>", "and", "then", "exposed", "to", "C0812313#ent", "<e2>", ",", "pHn", "3.5", ",", "had", "extensive", "morphological", "damage", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812313", "name": "C0812313#ent", "pos": [11, 12]}}
{"token": ["Two", "of", "the", "patients", "had", "the", "extremely", "rare", "combination", "of", "C0007570#ent", "<e1>", "lack", "of", "intrinsic", "factor", "C0398650#ent", "<e2>"], "h": {"id": "C0007570", "name": "C0007570#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0398650", "name": "C0398650#ent", "pos": [16, 17]}}
{"token": ["Twenty-six", "axenic", "isolates", "of", "Giardia", "intestinalis", "established", "in", "Mexico", "City", "an", "11-year", "period", "from", "symptomatic", "and", "asymptomatic", "individuals", "with", "acute", "or", "C0151317#ent", "<e1>", "were", "typed", "C1516876#ent", "<e2>", "."], "h": {"id": "C0151317", "name": "C0151317#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [25, 26]}}
{"token": ["Recent", "epidemiologic", "investigation", "demonstrated", "that", "C0024530#ent", "<e1>", ",", "amebiasis", ",", "trypanosomiasis", ",", "leishmaniasis", "and", "C0010678#ent", "<e2>", "seemed", "important", "as", "judged", "from", "the", "number", "of", "infected", "individuals", ",", "primarily", "Japanese", "travellers", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010678", "name": "C0010678#ent", "pos": [14, 15]}}
{"token": ["PHD1", ",", "C1412925#ent", "<e1>", ",", "and", "PHD3", "are", "C3540623#ent", "<e2>", "regulate", "the", "stability", "of", "hypoxia-inducible", "factor", "alpha", "subunits", "HIF-alpha", ")", "."], "h": {"id": "C1412925", "name": "C1412925#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3540623", "name": "C3540623#ent", "pos": [8, 9]}}
{"token": ["These", "data", "provide", "vital", "basis", "in", "experimental", "approaches", "at", "modulating", "the", "effect", "of", "TNF", "in", "C0699949#ent", "<e1>", "conditions", "involving", "both", "C3813124#ent", "<e2>", "and", "mast", "cells"], "h": {"id": "C0699949", "name": "C0699949#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3813124", "name": "C3813124#ent", "pos": [20, 21]}}
{"token": ["However", ",", "using", "the", "same", "standard", "oligonucleotide", "probe", "C0070319#ent", "<e1>", "mRNA", ",", "we", "observed", "considerably", "greater", "C0669365#ent", "<e2>", "concentrations", "of", "the", "transcript", "in", "spleen", "than", "in", "liver", "."], "h": {"id": "C0070319", "name": "C0070319#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [16, 17]}}
{"token": ["Transient", "transfection", "studies", "C2987364#ent", "<e1>", "and", "E3-defective", "c-IAP1", "revealed", "that", "C1332415#ent", "<e2>", "is", "a", "direct", "target", "for", "c-IAP1-mediated", "ubiquitination", "and", "subsequent", "degradation", ",", "which", "are", "potentiated", "by", "the", "adaptor", "function", "TRAF2", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332415", "name": "C1332415#ent", "pos": [10, 11]}}
{"token": ["A", "rare", "C0019247#ent", "<e1>", "with", "around", "a", "hundred", "cases", "in", "France", ")", ",", "C0016037#ent", "<e2>", "characterized", "by", "heterotopic", "ossification", "congenital", "malformation", "the", "bones", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0016037", "name": "C0016037#ent", "pos": [13, 14]}}
{"token": ["Twenty-two", "patients", "with", "C0013395#ent", "<e1>", "without", "ulcer", "disease", "examined", "for", "C0017168#ent", "<e2>", "gastro-oesophageal", "sphincter", "pressure"], "h": {"id": "C0013395", "name": "C0013395#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [10, 11]}}
{"token": ["Bronchoalveolar", "lavage", "fluid", "TB", "patients", "had", "elevated", "levels", "of", "CCL4", "(", "macrophage", "inflammatory", "protein-1beta", ",", "C1332691#ent", "<e1>", "(", "RANTES", ")", ",", "and", "C1522507#ent", "<e2>", "(", "fractalkine", ")", ",", "but", "not", "CXCL12", "(", "stromal-derived", "factor-1alpha", ")", "."], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1522507", "name": "C1522507#ent", "pos": [22, 23]}}
{"token": ["This", "enabled", "us", "to", "identify", "neuronkinin-1", "projection", "neurons", "in", "the", "C1420364#ent", "<e1>", "that", "express", "C1706383#ent", "<e2>", "and", "to", "determine", "if", "such", "cells", "receive", "contacts", "from", "alpha2C-AR", "terminals", "."], "h": {"id": "C1420364", "name": "C1420364#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [14, 15]}}
{"token": ["C0275544#ent", "<e1>", "to", "be", "common", "in", "women", "at", "risk", "for", "C0008149#ent", "<e2>", "and", "spread", "to", "the", "upper", "tract", "occur", "shortly", "after", "the", "infection", "is", "acquired", "."], "h": {"id": "C0275544", "name": "C0275544#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008149", "name": "C0008149#ent", "pos": [10, 11]}}
{"token": ["Clinical", "features", "of", "hereditary", "motor", "sensory", "neuropathy", "type", "VI", "muscle", "weakness", "atrophy", "in", "leg", "and", "hand", "muscles", "leading", "to", "progressive", "disability", "and", "C0042798#ent", "<e1>", "progressing", "to", "blindness", "due", "to", "C0029124#ent", "<e2>"], "h": {"id": "C0042798", "name": "C0042798#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [29, 30]}}
{"token": ["A", "similar", "depression", "was", "produced", "by", "the", "C1413156#ent", "<e1>", "inactive", "analogue", "glycyrrhizic", "acid", "the", "broad", "spectrum", "C0006684#ent", "<e2>", "ruthenium", "red"], "h": {"id": "C1413156", "name": "C1413156#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [16, 17]}}
{"token": ["The", "involvement", "of", "cyclic", "adenosine", "monophosphate", "C0010531#ent", "<e1>", "PKA", ")", "in", "the", "regulation", "of", "the", "C0290758#ent", "<e2>", "StAR", ")", "and", "the", "high-density", "lipoprotein", "receptor", "HDL-R", ")", "genes", "by", "steroidogenic", "factor-1", "SF-1", ")", "and", "cAMP", "were", "examined", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0290758", "name": "C0290758#ent", "pos": [15, 16]}}
{"token": ["This", "was", "a", "prospective", "randomised", "study", "the", "efficacy", "of", "C0972314#ent", "<e1>", "(", "Arcoxia", ")", "compared", "with", "C0025152#ent", "<e2>", "Ponstan", ")", "in", "treating", "primary", "dysmenorrhoea"], "h": {"id": "C0972314", "name": "C0972314#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025152", "name": "C0025152#ent", "pos": [16, 17]}}
{"token": ["These", "results", "suggest", "that", "C3887789#ent", "<e1>", "is", "a", "C1425716#ent", "<e2>", "the", "human", "papillomavirus", "E2", "protein"], "h": {"id": "C3887789", "name": "C3887789#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1425716", "name": "C1425716#ent", "pos": [8, 9]}}
{"token": ["Autoantibodies", "to", "GAD", "are", "also", "found", "in", "patients", "with", "C1861456#ent", "<e1>", "SMS", ")", "or", "polyendocrine", "autoimmunity", "C1412446#ent", "<e2>", ")", "."], "h": {"id": "C1861456", "name": "C1861456#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412446", "name": "C1412446#ent", "pos": [16, 17]}}
{"token": ["Similar", "studies", "on", "human", "cloned", "receptors", "that", "C0246836#ent", "<e1>", "is", "an", "agonist", "at", "human", "cloned", "C3814801#ent", "<e2>", "and", "5-HT1B", "receptors"], "h": {"id": "C0246836", "name": "C0246836#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3814801", "name": "C3814801#ent", "pos": [15, 16]}}
{"token": ["4", ")", "The", "inhibitory", "factor", "the", "d", "greater", "than", "1.24", "fraction", "can", "be", "partially", "purified", "by", "absorption", "to", "C0062515#ent", "<e1>", ",", "followed", "by", "elution", "with", "6", "C0120447#ent", "<e2>"], "h": {"id": "C0062515", "name": "C0062515#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0120447", "name": "C0120447#ent", "pos": [26, 27]}}
{"token": ["At", "present", ",", "it", "is", "not", "clear", "whether", "C0002876#ent", "<e1>", "II", "is", "a", "C1516876#ent", "<e2>", "heterogenous", "collection", "of", "glycosylation", "deficiencies", ",", "or", "C1516876#ent", "<e2>", "homogenous", "but", "apparently", "heterogenous", "in", "phenotype", "expression", "."], "h": {"id": "C0002876", "name": "C0002876#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [13, 14]}}
{"token": ["The", "Epstein-Barr", "virus", "C0149678#ent", "<e1>", ")", "EBNA-1", "protein", "a", "central", "role", "in", "the", "maintenance", "of", "a", "latent", "C0149678#ent", "<e1>", "infection", "and", "is", "the", "only", "C1418667#ent", "<e1>", "expressed", "in", "all", "EBV-associated", "tumors", "."], "h": {"id": "C0149678", "name": "C0149678#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418667", "name": "C1418667#ent", "pos": [24, 25]}}
{"token": ["An", "unusual", "case", "of", "diabetes", "secondary", "to", "C0001339#ent", "<e1>", "a", "boy", "with", "C2316810#ent", "<e2>", "continuous", "ambulatory", "peritoneal", "dialysis", "CAPD", ")", "is", "described", "."], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [12, 13]}}
{"token": ["This", "study", "was", "undertaken", "to", "examine", "the", "interaction", "of", "C1333570#ent", "<e1>", "with", "acetylcholinesterase", "(", "AChE", ")", "and", "C0021847#ent", "<e2>", "target", "esterase", "(", "NTE", ")", "of", "hen", "brain", "in", "vitro", "in", "vivo"], "h": {"id": "C1333570", "name": "C1333570#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [17, 18]}}
{"token": ["Efficient", "transfer", "of", "exogenous", "C0086376#ent", "<e1>", "into", "culture", "animal", "cells", "be", "achieved", "by", "Streptolysin", "O", "C3539661#ent", "<e2>", ")", "permeabilization", "of", "plasma", "membranes"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3539661", "name": "C3539661#ent", "pos": [15, 16]}}
{"token": ["Several", "thiazolidinediones", "2", "PTP1B", "inhibitory", "activity", "in", "the", "low", "micromolar", "range", "with", "moderate", "selectivity", "for", "human", "PTP1B", "and", "C1823488#ent", "<e1>", "isoform", "of", "human", "LMW-PTP", "compared", "with", "other", "related", "C1419129#ent", "<e2>", "."], "h": {"id": "C1823488", "name": "C1823488#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1419129", "name": "C1419129#ent", "pos": [28, 29]}}
{"token": ["In", "16", "(", "23.5", "%", ")", "an", "underlying", "C0242634#ent", "<e1>", "verified", ",", "and", "thus", "the", "C0156221#ent", "<e2>", "the", "secondary", "form"], "h": {"id": "C0242634", "name": "C0242634#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [15, 16]}}
{"token": ["Despite", "the", "C0206526#ent", "<e1>", "phenotype", ",", "high", "C1835417#ent", "<e2>", "levels", "concomitantly", "increased", "the", "expression", "of", "p53", ",", "p21", ",", "Bax", "and", "down-regulated", "Bcl-2", "."], "h": {"id": "C0206526", "name": "C0206526#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1835417", "name": "C1835417#ent", "pos": [7, 8]}}
{"token": ["This", "study", "examined", "the", "occurrence", "and", "possible", "function", "of", "C1412228#ent", "<e1>", "in", "the", "human", "C0771711#ent", "<e2>", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [14, 15]}}
{"token": ["C1412228#ent", "<e1>", "and", "its", "receptors", "are", "also", "present", "in", "the", "C0771711#ent", "<e2>", "and", "appear", "to", "play", "a", "regulatory", "role", "insulin", "secretion", "extremely", "low", "concentrations", "in", "a", "glucose-dependent", "manner", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "C1412228#ent", "<e1>", "occurs", "in", "human", "C0771711#ent", "<e2>", "and", "stimulates", "insulin", "and", "glucagon", "secretion", "in", "humans", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [8, 9]}}
{"token": ["Interestingly", ",", "blocking", "C0872913#ent", "<e1>", "proteolytic", "activity", "either", "C0872913#ent", "<e1>", "stop", "or", "neuroserpin", "did", "not", "prevent", "this", "C0242912#ent", "<e1>", "."], "h": {"id": "C0872913", "name": "C0872913#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [17, 18]}}
{"token": ["Lactulose", "administration", "induced", "a", "significant", "reduction", "of", "C2364135#ent", "<e1>", "threshold", "in", "subjects", "with", "C0016952#ent", "<e2>", "not", "in", "malabsorbers", "without", "intolerance", "symptoms", "or", "in", "subjects", "with", "normal", "lactose", "absorption"], "h": {"id": "C2364135", "name": "C2364135#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [13, 14]}}
{"token": ["Finally", ",", "despite", "the", "presence", "of", "C0024115#ent", "<e1>", "patients", "with", "C1370824#ent", "<e2>", "these", "patients", "can", "be", "expected", "to", "improve", "significantly", "after", "resection", ",", "and", "the", "long-term", "outcome", "is", "generally", "good", "."], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C1370824", "name": "C1370824#ent", "pos": [10, 11]}}
{"token": ["These", "differences", "would", "be", "compatible", "with", "a", "predominant", "C0085096#ent", "<e1>", "action", "for", "amlodipine", ",", "in", "contrast", "with", "mixed", "cardiac", "peripheral", "sites", "C0282138#ent", "<e2>", "and", "verapamil", "."], "h": {"id": "C0085096", "name": "C0085096#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [21, 22]}}
{"token": ["An", "organotypic", "culture", "model", "employed", "here", "to", "examine", "the", "effects", "of", "tamoxifen", "and", "C0618111#ent", "<e1>", ",", "a", "related", "compound", "with", "no", "known", "adverse", "C0567085#ent", "<e2>", "effects", ",", "on", "epithelial", "cells", "the", "premenopausal", "human", "endometrium", "."], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [23, 24]}}
{"token": ["Incubations", "of", "C0618111#ent", "<e1>", "and", "DMA", "COATags", "with", "rat", "C0567085#ent", "<e2>", "microsomes", "showed", "several", "modified", "proteins", "by", "Western", "blot", "analysis"], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [9, 10]}}
{"token": ["The", "in", "vivo", "activator", "of", "C1413811#ent", "<e1>", "itself", "is", "unknown", ";", "however", ",", "C0054871#ent", "<e2>", "S", "are", "candidates", "because", "they", "activate", "pro-DPPI", "in", "vitro"], "h": {"id": "C1413811", "name": "C1413811#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0054871", "name": "C0054871#ent", "pos": [13, 14]}}
{"token": ["At", "the", "same", "time", "5H5F8", "strongly", "inhibits", "C0019484#ent", "<e1>", "release", "and", "C0001477#ent", "<e2>", "after", "Ag", "triggering", "from", "human", "IgE-sensitized", "RBL-2H3", "cells", "stably", "transfected", "with", "human", "FcepsilonRIalpha", "."], "h": {"id": "C0019484", "name": "C0019484#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [11, 12]}}
{"token": ["Each", "C1705341#ent", "<e1>", "isoform", "contributed", "to", "C0244987#ent", "<e2>", "and", "GSK-3beta", "phosphorylation", ",", "with", "PKBbeta", "having", "the", "predominant", "role", "."], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0244987", "name": "C0244987#ent", "pos": [6, 7]}}
{"token": ["The", "hepatic", "biopsies", "steatosis", "in", "53", "cases", ",", "centrilobular", "sclerosis", "in", "32", "cases", "and", "C1623038#ent", "<e1>", "in", "19.8", "patients", "developed", "hepatic", "encephalopathy", "3", "had", "C0035078#ent", "<e2>", "and", "4", "died", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [24, 25]}}
{"token": ["The", "treatment", "of", "refractory", "ascites", "remains", "a", "challenge", "in", "C1623038#ent", "<e1>", "with", "ascites", "and", "end-stage", "renal", "disease", "C0035078#ent", "<e2>", ")", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [17, 18]}}
{"token": ["A", "recently", "observed", "case", ",", "initially", "characterized", "by", "C0235025#ent", "<e1>", "subsequently", "by", "C0018801#ent", "<e2>", "sudden", "death", "is", "described", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}}
{"token": ["Nine", "days", "following", "ingestion", "of", "5", "to", "10", "gm", "of", "thallium", "nitrate", "a", "young", "man", "died", "with", "severe", "cranial", "and", "C0235025#ent", "<e1>", "anuria", ",", "and", "C0018801#ent", "<e2>"], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [25, 26]}}
{"token": ["Using", "a", "yeast", "genetic", "screen", "select", "C0907533#ent", "<e1>", "active", "mutants", "from", "a", "randomly", "mutagenized", "C1416588#ent", "<e2>", "library", ",", "we", "identified", "five", "gating", "mutations", "four", "residues", "in", "the", "transmembrane", "domain"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416588", "name": "C1416588#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "C0001645#ent", "<e1>", "propranolol", ",", "pindolol", ",", "atenolol", ",", "bunitrolol", ",", "and", "C0041030#ent", "<e2>", "on", "the", "vascular", "resistance", "isolated", "perfused", "hindlimbs", "of", "rats", "were", "investigated", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041030", "name": "C0041030#ent", "pos": [14, 15]}}
{"token": ["Their", "analysis", "reveals", "key", "features", "of", "the", "C1705627#ent", "<e1>", "and", "ER", "ligand", "binding", "pocket", "(", "C1414322#ent", "<e2>", ")", "responsible", "for", "ligand", "selectivity", "."], "h": {"id": "C1705627", "name": "C1705627#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414322", "name": "C1414322#ent", "pos": [15, 16]}}
{"token": ["It", "has", "been", "proposed", "that", "C4284026#ent", "<e1>", "PDI", ")", "is", "closely", "related", "to", "the", "C0669524#ent", "<e2>"], "h": {"id": "C4284026", "name": "C4284026#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669524", "name": "C0669524#ent", "pos": [14, 15]}}
{"token": ["The", "ciliotoxicity", "of", "C0059788#ent", "<e1>", "(", "methyl", "paraben", "MHB", ")", "and", "propyl", "hydroxybenzoate", "propyl", "paraben", "C1335208#ent", "<e2>", ")", "was", "investigated", "."], "h": {"id": "C0059788", "name": "C0059788#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335208", "name": "C1335208#ent", "pos": [15, 16]}}
{"token": ["Interestingly", ",", "we", "also", "found", "the", "Lewis(X", ")", "and", "Lewis(Y", ")", "antigens", "co-expressed", "on", "several", "C0039902#ent", "<e1>", "isoforms", "of", "ATP", ":", "guanidino", "kinase", "C3536868#ent", "<e2>"], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3536868", "name": "C3536868#ent", "pos": [23, 24]}}
{"token": ["All", "mutant", "genes", "contained", "two", "to", "four", "mutations", "resulting", "in", "C2917660#ent", "<e1>", "substitutions", "within", "the", "penicillin-binding", "domain", "C1335237#ent", "<e2>", "2x", ",", "and", "none", "of", "the", "mutants", "carried", "an", "identical", "set", "of", "mutations", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335237", "name": "C1335237#ent", "pos": [17, 18]}}
{"token": ["Eighty", "five", "patients", "with", "C0035457#ent", "<e1>", "currently", "symptomatic", ",", "were", "treated", "with", "C0082607#ent", "<e2>", "proportionate", "nasal", "spray", "Flixonase", ")", "in", "open", ",", "multicentre", "efficacy", "safety", "study"], "h": {"id": "C0035457", "name": "C0035457#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0082607", "name": "C0082607#ent", "pos": [12, 13]}}
{"token": ["C0012498#ent", "<e1>", "might", "have", "inhibited", "the", "microsomal", "CYP2C9", "oxidation", "of", "C0700583#ent", "<e2>"], "h": {"id": "C0012498", "name": "C0012498#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [10, 11]}}
{"token": ["We", "measured", "bone", "mass", "density", "BMD", ")", "in", "28", "childhood-onset", "adult", "C0271561#ent", "<e1>", "patients", "(", "20", "MPHD", ",", "8", "C1415936#ent", "<e2>", ")", "treated", "with", "hGH", "until", "final", "height"], "h": {"id": "C0271561", "name": "C0271561#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415936", "name": "C1415936#ent", "pos": [19, 20]}}
{"token": ["Among", "these", "patients", ",", "severe", "C0271561#ent", "<e1>", "in", "adulthood", "generally", "confirmed", "in", "oGHD", ",", "is", "frequent", "in", "C1415936#ent", "<e2>", ",", "but", "never", "occurs", "in", "GHNSD", "."], "h": {"id": "C0271561", "name": "C0271561#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415936", "name": "C1415936#ent", "pos": [17, 18]}}
{"token": ["The", "Mu", "B", "protein", "is", "an", "ATP-dependent", "C0812382#ent", "<e1>", "an", "allosteric", "activator", "of", "the", "C0757968#ent", "<e2>"], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0757968", "name": "C0757968#ent", "pos": [14, 15]}}
{"token": ["His", "drug", "therapy", "consisted", "of", "digoxin", ",", "C0118168#ent", "<e1>", ",", "and", "furosemide", "for", "C0018802#ent", "<e2>", "allopurinol", "for", "gout", ",", "and", "potassium", "supplementation"], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["While", ",", "C0393593#ent", "<e1>", "tics", "in", "GTS", "and", "symptoms", "in", "C1859598#ent", "<e2>", "reflect", "the", "development", "of", "the", "causative", "neurons", "and", "the", "neuronal", "systems"], "h": {"id": "C0393593", "name": "C0393593#ent", "pos": [2, 3]}, "relation": "manifestation_of", "t": {"id": "C1859598", "name": "C1859598#ent", "pos": [10, 11]}}
{"token": ["We", "postulated", "that", "C3815531#ent", "<e1>", "may", "be", "responsible", ",", "in", "part", ",", "for", "the", "C0235025#ent", "<e2>", "in", "subjects", "receiving", "DCA", "."], "h": {"id": "C3815531", "name": "C3815531#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [14, 15]}}
{"token": ["The", "overall", "polypeptide", "backbone", "fold", "of", "C0530268#ent", "<e1>", "similar", "to", "other", "C1416671#ent", "<e2>", "despite", "a", "lack", "of", "significant", "sequence", "homology", "."], "h": {"id": "C0530268", "name": "C0530268#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [11, 12]}}
{"token": ["We", "report", "our", "experience", "on", "the", "technical", "feasibility", "and", "impact", "on", "quality", "of", "life", "C0518214#ent", "<e1>", ")", "for", "angioplasty", "and", "primary", "stenting", "chronic", "total", "occlusion", "C2984031#ent", "<e2>", ")", "of", "the", "superficial", "femoral", "artery", "SFA", ")", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2984031", "name": "C2984031#ent", "pos": [25, 26]}}
{"token": ["In", "the", "order", "of", "potency", "L-648,051", "greater", "than", "C0060706#ent", "<e1>", "greater", "than", "L-649,923", ",", "these", "C0991617#ent", "<e2>", "antagonized", "contractions", "to", "LTD4", "and", "produced", "parallel", "rightward", "shifts", "in", "the", "dose-response", "curves", "."], "h": {"id": "C0060706", "name": "C0060706#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [15, 16]}}
{"token": ["Pretreatment", "with", "C1823635#ent", "<e1>", ",", "but", "not", "C0720810#ent", "<e2>", ",", "also", "effectively", "prevented", "an", "elevation", "of", "intracellular", "levels", "of", "calcium", "provoked", "by", "rotenone", "."], "h": {"id": "C1823635", "name": "C1823635#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0720810", "name": "C0720810#ent", "pos": [7, 8]}}
{"token": ["Increases", "in", "cell-surface", "intercellular", "adhesion", "molecule-1", "ICAM-1", ";", "CD54", ")", "and", "major", "C0024518#ent", "<e1>", "MHC-I", ")", "and", "class", "II", "MHC-II", ")", "expression", "during", "C0206608#ent", "<e2>", "murine", "macrophages", "was", "strongly", "dependent", "on", "adherence", "status"], "h": {"id": "C0024518", "name": "C0024518#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0206608", "name": "C0206608#ent", "pos": [23, 24]}}
{"token": ["C0006644#ent", "<e1>", "also", "a", "strong", "stimulator", "of", "C0027021#ent", "<e2>", "secretion", "."], "h": {"id": "C0006644", "name": "C0006644#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [7, 8]}}
{"token": ["The", "highest", "specific", "activities", ",", "almost", "comparable", "to", "those", "of", "liver", "C0010762#ent", "<e1>", "were", "detected", "with", "C0041256#ent", "<e2>", "the", "rabbit", "intestine", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041256", "name": "C0041256#ent", "pos": [16, 17]}}
{"token": ["C0175692#ent", "<e1>", "JBS", ")", "is", "a", "rare", "autosomal", "recessive", "condition", "associated", "with", "C0267963#ent", "<e2>", "and", "is", "characterized", "by", "hypoplastic", "nasal", "alae", "mental", "retardation", "sensorineural", "hearing", "loss", "short", "stature", "scalp", "defects", ",", "dental", "abnormalities", "abnormal", "hair", "patterns"], "h": {"id": "C0175692", "name": "C0175692#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0267963", "name": "C0267963#ent", "pos": [12, 13]}}
{"token": ["Main", "clinical", "syndromes", ":", "icterus", "and/or", "C0039082#ent", "<e1>", "50", "%", "of", "patients", ",", "C2242703#ent", "<e2>", "65", "%", ",", "acute", "myalgies", "58", "%", "and", "pulmonary", "syndrome", "50", "%", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C2242703", "name": "C2242703#ent", "pos": [13, 14]}}
{"token": ["An", "overexpression", "of", "mortalin", ",", "but", "not", "of", "C1415782#ent", "<e1>", ",", "extended", "the", "in", "vitro", "of", "normal", "fibroblasts", "(", "C1422509#ent", "<e2>", ")", "."], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422509", "name": "C1422509#ent", "pos": [19, 20]}}
{"token": ["These", "findings", "point", "to", "the", "possibility", "that", "C0876973#ent", "<e1>", "mucoid", "P.", "aeruginosa", "CF", "may", "be", "an", "C0020951#ent", "<e2>"], "h": {"id": "C0876973", "name": "C0876973#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [16, 17]}}
{"token": ["C0006938#ent", "<e1>", "inhibits", "the", "angiotensin-converting", "enzyme", "but", "also", "affects", "C3536863#ent", "<e2>", "excretion", "and", "should", "be", "reassessed", "as", "a", "possible", "first-choice", "antihypertensive", "agent", "the", "treatment", "of", "essential", "hypertension"], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [9, 10]}}
{"token": ["The", "expression", "of", "genes", "encoding", "complement", "proteins", "C3", "C5", ",", "and", "C1413029#ent", "<e1>", "was", "studied", "following", "tumor", "PDT", "mediated", "by", "C0121300#ent", "<e2>", "mouse", "Lewis", "lung", "carcinoma", "LLC", ")", "model", "."], "h": {"id": "C1413029", "name": "C1413029#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0121300", "name": "C0121300#ent", "pos": [20, 21]}}
{"token": ["The", "2-oxo-acid", "C0171406#ent", "<e1>", ",", "in", "particular", ",", "the", "E2", "component", "of", "the", "C0034344#ent", "<e2>", "PDC", ")", "are", "the", "target", "of", "antimitochondrial", "antibodies", "AMA", ")", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034344", "name": "C0034344#ent", "pos": [13, 14]}}
{"token": ["Decreases", "in", "the", "levels", "of", "several", "mitochondrial", "proteins", "subunits", "of", "C0171406#ent", "<e1>", "complex", "V", "and", "of", "the", "C0034344#ent", "<e2>", "were", "observed", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034344", "name": "C0034344#ent", "pos": [17, 18]}}
{"token": ["Baculovirus-expressed", "human", "C1414645#ent", "<e1>", "as", "well", "as", "C3714798#ent", "<e2>", ",", "oxidized", "M25", "to", "M16", ",", "whereas", "further", "oxidation", "of", "M16", "to", "M20", "was", "catalyzed", "mainly", "by", "C3714798#ent", "<e2>", "."], "h": {"id": "C1414645", "name": "C1414645#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [7, 8]}}
{"token": ["Dopamine", "after", "iproniazid", "and", "C0025741#ent", "<e1>", "were", "inactive", "if", "a", "dopamine-beta-hydroxylase", "inhibitor", "disulphiram", "or", "C0700086#ent", "<e2>", "was", "present.4", "."], "h": {"id": "C0025741", "name": "C0025741#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0700086", "name": "C0700086#ent", "pos": [14, 15]}}
{"token": ["Approaches", "to", "patients", "with", "C0850758#ent", "<e1>", "vulvar", "disease", "disorders", "of", "menstruation", ",", "premenstrual", "syndrome", "and", "C0006145#ent", "<e2>", "addressed", "."], "h": {"id": "C0850758", "name": "C0850758#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006145", "name": "C0006145#ent", "pos": [15, 16]}}
{"token": ["We", "find", "that", "among", "the", "EET", "and", "C0058031#ent", "<e1>", "regioisomers", ",", "14,15-DHET", "is", "the", "most", "potent", "C2984537#ent", "<e2>", "a", "COS-7", "cell", "system", "."], "h": {"id": "C0058031", "name": "C0058031#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2984537", "name": "C2984537#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "demonstrate", "that", "synaptosomal", "uptake", "of", "[3H]NE", ",", "[3H]DA", "and", "[3H]5-HT", "in", "cortex", "and", "C0002707#ent", "<e1>", "are", "not", "altered", "in", "C0027404#ent", "<e2>", "."], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0027404", "name": "C0027404#ent", "pos": [21, 22]}}
{"token": ["Consistent", "with", "these", "findings", ",", "dansylcadaverine", "inhibited", "IGF-I-stimulated", "Shc-Grb2", "association", ",", "C0287531#ent", "<e1>", "and", "p90", "ribosomal", "S6", "kinase", "activation", "but", "did", "not", "affect", "the", "association", "of", "C1519050#ent", "<e2>", "IRS-1", "or", "activation", "of", "p70", "S6", "kinase"], "h": {"id": "C0287531", "name": "C0287531#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1519050", "name": "C1519050#ent", "pos": [26, 27]}}
{"token": ["The", "C1540912#ent", "<e1>", "groups", "together", "patients", "with", "C0311368#ent", "<e2>", "diffuse", "organ", "infiltration", "with", "eosinophils", "."], "h": {"id": "C1540912", "name": "C1540912#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0311368", "name": "C0311368#ent", "pos": [7, 8]}}
{"token": ["C1540912#ent", "<e1>", "a", "subclass", "of", "C0311368#ent", "<e2>", "requires", "the", "documentation", "of", "both", "sustained", "eosinophilia", "(", ">", "or", "=", "1500/microL", "for", "at", "least", "6", "months", ")", "and", "target-organ", "damage", "."], "h": {"id": "C1540912", "name": "C1540912#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0311368", "name": "C0311368#ent", "pos": [5, 6]}}
{"token": ["Alternatively", ",", "FL", "may", "be", "cleaved", "oxidatively", "to", "form", "N(epsilon)-(carboxymethyl)lysine", "(", "CML", ")", ",", "while", "glycated", "hydroxylysine", "an", "amino-acid", "unique", "to", "C0009325#ent", "<e1>", ",", "may", "yield", "N(epsilon)-(carboxymethyl)hydroxylysine", "(", "C0083533#ent", "<e2>", ")", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0083533", "name": "C0083533#ent", "pos": [28, 29]}}
{"token": ["No", "mutations", "were", "identified", "in", "the", "entire", "coding", "area", "the", "ACTH", "receptor", "the", "2", "families", "with", "C0271742#ent", "<e1>", "supporting", "the", "idea", "of", "a", "developmental", "or", "postreceptor", "defect", "this", "C0039082#ent", "<e2>", "."], "h": {"id": "C0271742", "name": "C0271742#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [28, 29]}}
{"token": ["ADAM33", ",", "a", "disintegrin", "and", "metalloproteinase", "33", "gene", "has", "been", "identified", "as", "a", "risk", "factor", "asthma", "and", "C0085129#ent", "<e1>", "has", "been", "postulated", "as", "a", "C0079429#ent", "<e2>", "for", "airway", "remodeling", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [24, 25]}}
{"token": ["This", "mapping", "information", "in", "the", "mouse", "may", "relate", "to", "human", "studies", "in", "which", "C0085129#ent", "<e1>", "to", "the", "chromosomal", "region", "the", "C0079429#ent", "<e2>", "for", "IL-5", "(", "1", ")", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [20, 21]}}
{"token": ["We", "report", "here", "that", ",", "unexpectedly", ",", "overexpression", "of", "human", "NF-L", "proteins", "in", "extra", "axonal", "C1826396#ent", "<e1>", "does", "not", "shorten", "the", "life", "span", "transgenic", "mice", "expressing", "a", "mutant", "C1420306#ent", "<e2>", "(", "SOD1(G37R", ")", ")", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [28, 29]}}
{"token": ["C1826396#ent", "<e1>", "(NF)-bound", "AGEs", "colocalize", "immunochemically", "with", "C1420306#ent", "<e2>", "in", "the", "motoneurons", "of", "patients", "with", "ALS", "."], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420306", "name": "C1420306#ent", "pos": [7, 8]}}
{"token": ["The", "C1420552#ent", "<e1>", "family", "now", "is", "represented", "by", "at", "least", "9", "distinct", "C0017337#ent", "<e2>", "and", "includes", "enzymes", "that", "fall", "into", "4", "subfamilies", "based", "on", "their", "activities", "toward", "various", "5-phosphatase", "substrates", "."], "h": {"id": "C1420552", "name": "C1420552#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["It", "is", "hypothesized", "that", "C0033634#ent", "<e1>", "a", "causative", "part", "the", "development", "of", "vasospasm", "after", "C0038525#ent", "<e2>", "SAH", ")", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038525", "name": "C0038525#ent", "pos": [14, 15]}}
{"token": ["During", "fetal", "lung", "development", "the", "activities", "of", "C0008415#ent", "<e1>", "cholinephosphate", "cytidyltransferase", "little", ",", "cholinephosphotranserase", "decreased", "while", "C2742256#ent", "<e2>", "lysolecithin", "acyltransferase", "increased", "."], "h": {"id": "C0008415", "name": "C0008415#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2742256", "name": "C2742256#ent", "pos": [16, 17]}}
{"token": ["Most", "of", "the", "major", "spliceosomal", "small", "nuclear", "RNAs", "(", "snRNAs", ")", "(", "i.e.", "U1", ",", "U2", ",", "C1419545#ent", "<e1>", "and", "U5", ")", "are", "synthesized", "by", "C0035679#ent", "<e2>", "pol", "II", "."], "h": {"id": "C1419545", "name": "C1419545#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [25, 26]}}
{"token": ["Most", "of", "the", "major", "spliceosomal", "small", "nuclear", "RNAs", "(", "snRNAs", ")", "(", "i.e.", "U1", ",", "U2", ",", "C1419545#ent", "<e1>", "and", "U5", ")", "are", "synthesized", "by", "RNA", "polymerase", "II", "C0035679#ent", "<e2>", "."], "h": {"id": "C1419545", "name": "C1419545#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [28, 29]}}
{"token": ["A", "close", "relationship", "has", "been", "observed", "between", "the", "clearance", "rates", "sodium", "and", "C2936886#ent", "<e1>", "under", "a", "variety", "of", "C0012798#ent", "<e2>"], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [18, 19]}}
{"token": ["The", "rat", "and", "human", "heart", "and", "aorta", "have", "been", "previously", "found", "to", "express", "both", "A2-type", "adenosine", "receptors", "which", "activate", "C0001492#ent", "<e1>", "and", "A3", "adenosine", "receptors", "C1704925#ent", "<e2>", ")", ",", "which", "inhibit", "C0001492#ent", "<e1>"], "h": {"id": "C1704925", "name": "C1704925#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [19, 20]}}
{"token": ["C3273276#ent", "<e1>", "is", "specifically", "implicated", "in", "neuronal", "plasticity", "and", "also", "regulates", "C1539078#ent", "<e2>", "neuronal", "migration", "and", "apoptosis", "."], "h": {"id": "C3273276", "name": "C3273276#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [11, 12]}}
{"token": ["Cytochromes", "P4502A6", "CYP2A6", ")", "and", "P4501A2", "(", "C1620185#ent", "<e1>", ")", "were", "described", "as", "hepatic", "autoantigens", "the", "C0085409#ent", "<e2>", "APS-1", ")", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085409", "name": "C0085409#ent", "pos": [16, 17]}}
{"token": ["The", "toxicity", "of", "C0053387#ent", "<e1>", "in", "mice", "with", "C0022660#ent", "<e2>", "induced", "by", "uranyl", "acetate", "investigated", "."], "h": {"id": "C0053387", "name": "C0053387#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [8, 9]}}
{"token": ["The", "expression", "of", "CD45", "therefore", "regulates", "the", "phosphorylation", "and", "potentially", "the", "activity", "of", "the", "C3853652#ent", "<e1>", "and", "fyn", "tyrosine", "protein", "kinases", "but", "the", "effect", "on", "the", "C0919477#ent", "<e2>", "much", "greater", "than", "on", "the", "fyn", "kinase"], "h": {"id": "C3853652", "name": "C3853652#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919477", "name": "C0919477#ent", "pos": [26, 27]}}
{"token": ["The", "noradrenaline", "output", "evoked", "by", "activation", "of", "the", "presynaptic", "5-hydroxytryptamine", "receptors", "5-hydroxytryptamine", "was", "decreased", "by", "ethanol", ",", "C3495432#ent", "<e1>", "halothane", ",", "thiopental", "and", "C0013136#ent", "<e2>", "."], "h": {"id": "C3495432", "name": "C3495432#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0013136", "name": "C0013136#ent", "pos": [23, 24]}}
{"token": ["Total", "antioxidation", "capacity", ",", "the", "level", "of", "C0039925#ent", "<e1>", "acid-reactive", "substances", "and", "superoxide", "scavenging", "capacity", "in", "the", "C0068450#ent", "<e2>", "group", "were", "greater", "than", "in", "the", "control", "group"], "h": {"id": "C0039925", "name": "C0039925#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0068450", "name": "C0068450#ent", "pos": [17, 18]}}
{"token": ["These", "results", "suggest", "that", "C3160718#ent", "<e1>", "patients", "have", "a", "lower", "risk", "of", "C0003850#ent", "<e2>", "."], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [12, 13]}}
{"token": ["hyh", "mice", "carry", "a", "hypomorphic", "missense", "mutation", "the", "gene", "Napa", "soluble", "C0067966#ent", "<e1>", "NSF", ")", "attachment", "C2362546#ent", "<e2>", "alpha", "Snap", ",", "involved", "in", "SNAP", "receptor", "vesicle", "fusion", "in", "many", "cellular", "contexts"], "h": {"id": "C0067966", "name": "C0067966#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2362546", "name": "C2362546#ent", "pos": [16, 17]}}
{"token": ["Purified", "C3538705#ent", "<e1>", "and", "cathepsin", "G", "CD2", ",", "CD4", ",", "and", "C1706438#ent", "<e2>", "on", "peripheral", "blood", "T", "lymphocytes", "proteinase", "concentrations", "of", "0.83", "to", "8.3", "microM", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C3538705", "name": "C3538705#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [11, 12]}}
{"token": ["None", "of", "the", "15", "patients", "with", "proven", "C0019342#ent", "<e1>", "a", "positive", "VZV", "C0281643#ent", "<e2>", ",", "nor", "did", "any", "patient", "with", "positive", "VZV", "viral", "culture", "a", "negative", "VZV", "C0281643#ent", "<e2>", "."], "h": {"id": "C0019342", "name": "C0019342#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0281643", "name": "C0281643#ent", "pos": [12, 13]}}
{"token": ["Whereas", "little", "evidence", "to", "any", "functional", "significance", "of", "the", "C0108555#ent", "<e1>", "sites", "in", "C0079068#ent", "<e2>", "has", "been", "obtained", ",", "phosphorylation", "of", "its", "heterodimeric", "partner", "Max", "DNA", "binding", "properties", "."], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [13, 14]}}
{"token": ["The", "C0014442#ent", "<e1>", "inhibited", "by", "C0301366#ent", "<e2>", "(", "kII=0.44x102", "M-1", "min-1", ")", "was", "not", "reactivated", "by", "pralidoxime", "methiodide", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0301366", "name": "C0301366#ent", "pos": [5, 6]}}
{"token": ["G117H", "is", "the", "only", "C0014442#ent", "<e1>", "known", "that", "hydrolyzes", "C0301366#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0301366", "name": "C0301366#ent", "pos": [9, 10]}}
{"token": ["ANF", "levels", "were", "not", "able", "to", "differentiate", "chagasic", "asymptomatic", "and", "C1705969#ent", "<e1>", "patients", "from", "healthy", "subjects", "CD", "controls", ";", "meanwhile", ",", "chagasic", "C0019099#ent", "<e2>", "patients", "showed", "lower", "plasma", "ANF", "than", "their", "controls", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [22, 23]}}
{"token": ["A", "ceroid-lipofuscinosis-affected", "Tibetan", "terrier", "homozygous", "for", "a", "Gly70Glu", "C0751383#ent", "<e1>", "variant", ";", "however", ",", "this", "C1706112#ent", "<e2>", "is", "common", "in", "dog", "breeds", "free", "of", "ceroid-lipofuscinosis", "."], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [15, 16]}}
{"token": ["It", "was", "recently", "shown", "that", "the", "beta2", "subunit", "to", "the", "sedative", "properties", "of", "etomidate", ",", "whereas", "the", "C2698300#ent", "<e1>", "responsible", "for", "its", "C0002932#ent", "<e2>"], "h": {"id": "C2698300", "name": "C2698300#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0002932", "name": "C0002932#ent", "pos": [22, 23]}}
{"token": ["C0206042#ent", "<e1>", "is", "associated", "with", "aspartic", "acid", "asparagine", "mutation", "codon", "178", "of", "the", "C3889430#ent", "<e2>", "D178N", ")", "in", "conjunction", "with", "methionine", "at", "the", "codon", "129", "polymorphic", "site", "the", "mutant", "allele", "cis-129", "M", ")", "."], "h": {"id": "C0206042", "name": "C0206042#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889430", "name": "C3889430#ent", "pos": [13, 14]}}
{"token": ["The", "inhibition", "of", "EGF", "receptor", "tyrosine", "kinase", "C0057137#ent", "<e1>", "was", "competitive", "to", "C2744579#ent", "<e2>", "and", "non-competitive", "to", "the", "peptide", "substrate"], "h": {"id": "C0057137", "name": "C0057137#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [12, 13]}}
{"token": ["When", "slices", "from", "C0085196#ent", "<e1>", "treated", "animals", "were", "preincubated", "with", "C0031441#ent", "<e2>", ",", "the", "loss", "in", "alpha", "1-adrenoceptor", "sites", "was", "greater", "than", "the", "reduction", "in", "the", "maximal", "response", "to", "noradrenaline", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031441", "name": "C0031441#ent", "pos": [10, 11]}}
{"token": ["While", "C0672708#ent", "<e1>", "induced", "the", "cyclin-dependent", "kinase", "inhibitor", "C0249197#ent", "<e2>", ",", "antisense", "ablation", "this", "CDKI", "increased", ",", "rather", "than", "decreased", ",", "SAHA-related", "lethality", "."], "h": {"id": "C0672708", "name": "C0672708#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0249197", "name": "C0249197#ent", "pos": [8, 9]}}
{"token": ["Our", "results", "suggest", "that", "BHA", "induction", "in", "murine", "C0023899#ent", "<e1>", "and", "intestinal", "mucosa", "class-mu", "and", "C0769262#ent", "<e2>", "involve", "regulatory", "elements", "mediators", "that", "function", "poorly", "in", "Hepa1c1c7", "cells", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0769262", "name": "C0769262#ent", "pos": [15, 16]}}
{"token": ["Both", "C1701455#ent", "<e1>", ",", "a", "wakefulness-promoting", "drug", "and", "pramipexole", ",", "a", "D(2)/D(3)receptor", "C0243192#ent", "<e2>", "with", "sedative", "properties", "may", "act", "on", "this", "pathway", ",", "with", "C1701455#ent", "<e1>", "increasing", "and", "pramipexole", "decreasing", "locus", "coeruleus", "activity", "."], "h": {"id": "C1701455", "name": "C1701455#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [12, 13]}}
{"token": ["This", "enzyme", "was", "undetectable", "in", "normal", "subjects", "patients", "with", "C0037274#ent", "<e1>", "whose", "clinical", "symptoms", "similar", "to", "those", "of", "C0011644#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0011644", "name": "C0011644#ent", "pos": [18, 19]}}
{"token": ["A", "trend", "was", "observed", "toward", "correction", "of", "hypernatremia", "or", "C0020625#ent", "<e1>", "with", "both", "types", "of", "C1963718#ent", "<e2>", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1963718", "name": "C1963718#ent", "pos": [15, 16]}}
{"token": ["It", "also", "had", "more", "favourable", "effects", "on", "C0020625#ent", "<e1>", "and", "metabolic", "acidosis", "a", "standard", "C1963718#ent", "<e2>", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1963718", "name": "C1963718#ent", "pos": [14, 15]}}
{"token": ["The", "conclusion", "is", "that", "C0073393#ent", "<e1>", "would", "be", "a", "good", "first-line", "antipsychotic", "drug", "the", "treatment", "of", "C0040517#ent", "<e2>"], "h": {"id": "C0073393", "name": "C0073393#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [16, 17]}}
{"token": ["We", "present", "a", "patient", "with", "C0423319#ent", "<e1>", "was", "normotensive", "and", "yet", "had", "C0010037#ent", "<e2>", "bullous", "keratopathy", "cleared", "upon", "lowering", "the", "intraocular", "pressure"], "h": {"id": "C0423319", "name": "C0423319#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010037", "name": "C0010037#ent", "pos": [12, 13]}}
{"token": ["We", "show", "here", "that", "administration", "of", "vitamin", "D3", "healthy", "individuals", "and", "SR", "C0004096#ent", "<e1>", "patients", "enhanced", "subsequent", "responsiveness", "to", "C0011777#ent", "<e2>", "for", "induction", "of", "IL-10", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [12, 13]}, "relation": "may_be_prevented_by", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [19, 20]}}
{"token": ["The", "finding", "that", "estrogens", "persist", "in", "the", "plasma", "of", "patients", "receiving", "C0002555#ent", "<e1>", "treatment", "despite", "a", "near", "total", "inhibition", "of", "the", "aromatase", "C0014442#ent", "<e2>", "suggests", "that", "alternative", "pathways", "for", "estrogen", "synthesis", "."], "h": {"id": "C0002555", "name": "C0002555#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [22, 23]}}
{"token": ["Mechanisms", "of", "VB6", "action", "on", "hepatic", "alanine", "glyoxylate", "aminotransferase", "C0002555#ent", "<e1>", ")", ",", "the", "deficient", "C0014442#ent", "<e2>", "in", "PHI", ",", "and", "VB6", "dose", "response", "have", "not", "been", "well-characterized", "."], "h": {"id": "C0002555", "name": "C0002555#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "compare", "the", "C0007193#ent", "<e1>", "induced", "by", "experimental", "diabetes", "mellitus", "C0022245#ent", "<e2>", "ISO", ")", "pretreatment", "on", "inotropic", "reactivity", "right", "ventricular", "strips", "rats", "."], "h": {"id": "C0007193", "name": "C0007193#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [15, 16]}}
{"token": ["C1420714#ent", "<e1>", "TG2", ")", "is", "a", "C0140145#ent", "<e2>", "has", "been", "implicated", "in", "the", "pathogenesis", "of", "neurodegenerative", "diseases", "ischemia", ",", "and", "stroke", "."], "h": {"id": "C1420714", "name": "C1420714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0140145", "name": "C0140145#ent", "pos": [6, 7]}}
{"token": ["C0010762#ent", "<e1>", "a", "member", "of", "the", "C1333195#ent", "<e2>", "catalyzes", "conversion", "of", "androgens", "to", "estrogens", "in", "a", "form", "of", "an", "enzyme-complex", "with", "NADPH-cytochrome", "P450", "reductase"], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333195", "name": "C1333195#ent", "pos": [6, 7]}}
{"token": ["C4084736#ent", "<e1>", "mRNA", "expression", "of", "C0074247#ent", "<e2>", "group", "increases", "compared", "with", "BD", "group", "."], "h": {"id": "C4084736", "name": "C4084736#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0074247", "name": "C0074247#ent", "pos": [5, 6]}}
{"token": ["To", "assess", "the", "efficacy", "of", "topical", "cyclosporine", "%", "(", "Restasis", ")", "in", "patients", "with", "herpes", "simplex", "virus", "nonnecrotizing", "C0022568#ent", "<e1>", "to", "topical", "C0032950#ent", "<e2>", "."], "h": {"id": "C0022568", "name": "C0022568#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [22, 23]}}
{"token": ["In", "humans", ",", "the", "IGF1R", "gene", "been", "mapped", "near", "C1414588#ent", "<e1>", ",", "the", "cellular", "counterpart", "of", "the", "C0812383#ent", "<e2>", ",", "at", "the", "q25-q26", "region", "of", "human", "chromosome", "15", "HSA15", ")", "."], "h": {"id": "C1414588", "name": "C1414588#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812383", "name": "C0812383#ent", "pos": [17, 18]}}
{"token": ["Aspergillus", "fumigatus", "an", "82", "kDa", "intracellular", "C1334706#ent", "<e1>", "that", "hydrolyses", "the", "C0084263#ent", "<e2>", ",", "4-phenylazobenzyloxycarbonyl-Pro-Leu-Gly-Pro-Arg", ",", "a", "typical", "substrate", "of", "members", "of", "the", "thimet", "oligopeptidase", "family", "which", "is", "ubiquitously", "distributed", "across", "animal", "species"], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0084263", "name": "C0084263#ent", "pos": [11, 12]}}
{"token": ["The", "rat", "liver", ",", "lung", "and", "kidney", "exhibited", "a", "band", "of", "nonspecific", "esterase", "activity", "migrated", "with", "purified", "human", "liver", "C1869509#ent", "<e1>", "C0020289#ent", "<e2>", "These", "observations", "suggest", "that", "rat", "hydrolase", "A", "similar", "to", "human", "C1869509#ent", "<e1>"], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [21, 22]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1869509", "name": "C1869509#ent", "pos": [19, 20]}}
{"token": ["77", "patients", "with", "aortic", "valve", "disease", "undergone", "heart", "catheterization", "prevision", "of", "valve", "replacement", "in", "this", "group", "the", "incidence", "of", "C0002962#ent", "<e1>", "the", "incidence", "of", "C0010054#ent", "<e2>", "associated", "with", "valvular", "disease", "been", "evaluated", "."], "h": {"id": "C0002962", "name": "C0002962#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [24, 25]}}
{"token": ["Our", "data", "point", "to", "a", "novel", "role", "of", "C1334146#ent", "<e1>", "in", "control", "of", "the", "proinflammatory/anti-inflammatory", "C1333196#ent", "<e2>", "network", "."], "h": {"id": "C1334146", "name": "C1334146#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [15, 16]}}
{"token": ["These", "results", "demonstrate", "that", "besides", "facilitating", "cell", "adhesion", "C1334146#ent", "<e1>", "serves", "as", "a", "potent", "co-stimulatory", "molecule", "inducing", "different", "C1333196#ent", "<e2>", "patterns", "depending", "on", "the", "ligand", "bound", "."], "h": {"id": "C1334146", "name": "C1334146#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [18, 19]}}
{"token": ["We", "describe", "the", "case", "of", "a", "29-year-old", "woman", "with", "C0553573#ent", "<e1>", "no", "history", "thrombosis", ",", "hypertension", "or", "C0022658#ent", "<e2>"], "h": {"id": "C0553573", "name": "C0553573#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [17, 18]}}
{"token": ["Five", "patients", "died", "before", "C0341221#ent", "<e1>", "developed", "on", "a", "background", "respiratory", "and", "C0600503#ent", "<e2>", "."], "h": {"id": "C0341221", "name": "C0341221#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0600503", "name": "C0600503#ent", "pos": [12, 13]}}
{"token": ["C2936904#ent", "<e1>", "a", "malformation", "syndrome", "the", "ventral", "midline", "characterized", "by", "hypertelorism", ",", "C0011168#ent", "<e2>", "hypospadias", "and", "developmental", "delay"], "h": {"id": "C2936904", "name": "C2936904#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [12, 13]}}
{"token": ["Previous", "studies", "of", "the", "guinea-pig", "and", "mouse", "intestine", "indicate", "that", "there", "are", "C1332691#ent", "<e1>", "expressions", "of", "C1826724#ent", "<e2>", "isoforms", "in", "neurons", ",", "muscle", "and", "the", "interstitial", "cells", "Cajal", "."], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [16, 17]}}
{"token": ["The", "median", "response", "durations", "were", "9.3", ",", "9.9", ",", "and", "7.8", "months", "for", "the", "combination", "with", "navelbine", ",", "C0042683#ent", "<e1>", "and", "the", "new", "C0042672#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0042683", "name": "C0042683#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [23, 24]}}
{"token": ["We", "demonstrated", "a", "novel", "catalytic", "mechanism", "the", "C1860707#ent", "<e1>", "C1419277#ent", "<e2>", "and", "Rheb", "that", "C1860707#ent", "<e1>", "uses", "a", "catalytic", "\"", "asparagine", "thumb", "instead", "of", "the", "arginine", "finger", "in", "Ras-GAP", "."], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1860707", "name": "C1860707#ent", "pos": [7, 8]}}
{"token": ["C0006864#ent", "<e1>", "been", "implicated", "in", "appetite", "control", "the", "respective", "hyperphagic", "and", "C0003123#ent", "<e2>", "actions", "of", "CB1", "agonists", "antagonists", "."], "h": {"id": "C0006864", "name": "C0006864#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003123", "name": "C0003123#ent", "pos": [11, 12]}}
{"token": ["Both", "AtGER2", "and", "AtGER3", "are", "oligomeric", "proteins", "share", "germin", "'s", "resistance", "to", "C0030909#ent", "<e1>", "and", "to", "dissociation", "by", "heat", "and", "C0272170#ent", "<e2>", "."], "h": {"id": "C0030909", "name": "C0030909#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [20, 21]}}
{"token": ["When", "precipitated", "by", "dialysis", "against", "dilute", "acetic", "acid", "the", "C0017366#ent", "<e1>", "separated", "from", "contaminating", "soluble", "C0009325#ent", "<e2>", "and", "other", "soluble", "proteins", "."], "h": {"id": "C0017366", "name": "C0017366#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [15, 16]}}
{"token": ["The", "dorsal", "pathway", "preferentially", "inhibited", "by", "C0012772#ent", "<e1>", ",", "while", "ventral", "synthesis", "preferentially", "inhibited", "by", "C0048363#ent", "<e2>", "."], "h": {"id": "C0012772", "name": "C0012772#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0048363", "name": "C0048363#ent", "pos": [15, 16]}}
{"token": ["The", "IRE1p", "expressing", "transfectants", "exhibited", "a", "modest", "(", "2-fold", ")", "enhancement", "of", "both", "the", "basal", "and", "Tg", "induced", "level", "of", "C1415761#ent", "<e1>", "and", "grp94", ",", "two", "coordinately", "regulated", "C1333714#ent", "<e2>"], "h": {"id": "C1415761", "name": "C1415761#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1333714", "name": "C1333714#ent", "pos": [28, 29]}}
{"token": ["High-affinity", "receptors", "interleukin-3", "(", "IL-3", ")", ",", "IL-5", ",", "and", "C1332791#ent", "<e1>", "GM-CSF", ")", "are", "composed", "of", "two", "distinct", "C0599220#ent", "<e2>", ",", "a", "ligand-specific", "chain", "and", "a", "common", "beta", "chain", "betac", ")", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [19, 20]}}
{"token": ["Total", "body", "clearance", "C0377265#ent", "<e1>", "is", "decreased", "in", "patients", "with", "C1565662#ent", "<e2>", "and", "doses", "should", "be", "modified", "according", "to", "creatinine", "clearance", "values", "."], "h": {"id": "C0377265", "name": "C0377265#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [10, 11]}}
{"token": ["C0016395#ent", "<e1>", "a", "rare", "C0037277#ent", "<e2>", "characterized", "by", "developmental", "defects", "the", "skin", ",", "resulting", "in", "widespread", "linear", "lesions", "dermal", "hypoplasia", "adipose", "tissue", "the", "dermis", "."], "h": {"id": "C0016395", "name": "C0016395#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037277", "name": "C0037277#ent", "pos": [4, 5]}}
{"token": ["To", "examine", "the", "expressions", "of", "E-cadherin", ",", "beta-catenin", "and", "cyclin", "D1", "the", "C0037284#ent", "<e1>", "patients", "with", "C0263361#ent", "<e2>", "and", "understand", "their", "possible", "roles", "in", "keratinocyte", "hyperproliferation", "these", "patients", "."], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0263361", "name": "C0263361#ent", "pos": [16, 17]}}
{"token": ["Alterations", "of", "C0031686#ent", "<e1>", "PP2A", "and", "PP1", ",", "during", "the", "C0035339#ent", "<e2>", "acid-induced", "differentiation", "HL-60", "cells", "been", "investigated", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035339", "name": "C0035339#ent", "pos": [10, 11]}}
{"token": ["By", "searching", "trypanosomatid", "genome", "databases", "four", "genes", "encoding", "proteins", "C1512488#ent", "<e1>", "to", "the", "mammalian", "C1418489#ent", "<e2>", "PFK-2/FBPase-2", ")", "were", "found", "for", "both", "T.", "brucei", "and", "the", "related", "parasite", "Leishmania", "major", "four", "pairs", "in", "Trypanosoma", "cruzi"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418489", "name": "C1418489#ent", "pos": [14, 15]}}
{"token": ["During", "pregnancy", "sufficient", "quantities", "of", "iodine", "are", "required", "to", "prevent", "the", "appearance", "of", "hypothyroidism", ",", "trophoblastic", "and", "embryonic", "or", "C0015929#ent", "<e1>", "neonatal", "and", "C0262548#ent", "<e2>", "and", "permanent", "sequelae", "infants", "."], "h": {"id": "C0015929", "name": "C0015929#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0262548", "name": "C0262548#ent", "pos": [23, 24]}}
{"token": ["The", "results", "raise", "the", "possibility", "that", "C0077589#ent", "<e1>", "might", "participate", "in", "opiate", "dependence", "C0152128#ent", "<e2>"], "h": {"id": "C0077589", "name": "C0077589#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0152128", "name": "C0152128#ent", "pos": [13, 14]}}
{"token": ["Endomorphin-1", "(", "C2698591#ent", "<e1>", ",", "H-Tyr-Pro-Trp-Phe-NH2", ")", "is", "a", "highly", "potent", "and", "selective", "C0243192#ent", "<e2>", "for", "the", "mu-opioid", "receptor"], "h": {"id": "C2698591", "name": "C2698591#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [13, 14]}}
{"token": ["Our", "objective", "was", "to", "quantify", "the", "early", "risk", "stroke", "after", "a", "C0007787#ent", "<e1>", "in", "patients", "with", "C0007273#ent", "<e2>"], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0007273", "name": "C0007273#ent", "pos": [16, 17]}}
{"token": ["Surfactant", "protein", "A", "C1420002#ent", "<e1>", ")", "is", "an", "oligomeric", "protein", "of", "18", "protomers", "with", "C0009325#ent", "<e2>", "and", "lectin-like", "domains", "that", "recognizes", "glycoconjugates", ",", "lipids", "and", "protein", "determinants", "both", "host", "cells", "invading", "microorganisms", "."], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}}
{"token": ["Both", "self-association", "and", "lipid-related", "functions", "of", "C1420002#ent", "<e1>", "were", "clearly", "correlated", "with", "the", "thermal", "stability", "the", "C0009325#ent", "<e2>", "the", "degree", "of", "oligomerization", "."], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [16, 17]}}
{"token": ["C0239377#ent", "<e1>", "involvement", "in", "the", "C1419235#ent", "<e2>", "--", "Waardenburg", "(", "K", "--", "W", ")", "syndrome", "is", "documented", "in", "two", "affected", "sibs", "and", "in", "four", "other", "previously", "reported", "patients", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419235", "name": "C1419235#ent", "pos": [5, 6]}}
{"token": ["We", "conclude", "that", "polyclonal", "antibodies", "be", "an", "important", "tool", "to", "investigate", "the", "characteristics", "and", "underlying", "mechanisms", "of", "secondary", "LCAT", "C2713546#ent", "<e1>", ",", "including", "those", "associated", "with", "hepatic", "cirrhosis", "C0036323#ent", "<e2>", "."], "h": {"id": "C2713546", "name": "C2713546#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [28, 29]}}
{"token": ["The", "bacteria", "or", "C3541394#ent", "<e1>", "responsible", "for", "the", "metabolism", "of", "C0246904#ent", "<e2>", "are", "located", "in", "the", "lower", "parts", "of", "the", "gastrointestinal", "tract"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0246904", "name": "C0246904#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "several", "steroid", "creams", "C0031667#ent", "<e1>", "PLA2", ")", "activity", "in", "symptomless", "C0003872#ent", "<e2>", "and", "normal", "epidermis", "studied", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [13, 14]}}
{"token": ["Surprisingly", ",", "incubation", "of", "cells", "with", "cycloheximide", "also", "caused", "down-regulation", "of", "PDGF-alpha", "receptor", "mRNA", ",", "which", "suggests", "that", "synthesis", "of", "a", "C1414509#ent", "<e1>", "necessary", "for", "C0669365#ent", "<e2>", "expression", "."], "h": {"id": "C1414509", "name": "C1414509#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [25, 26]}}
{"token": ["C0528166#ent", "<e1>", "is", "a", "new", "C0162757#ent", "<e2>", "excellent", "oral", "bioavailability", "exhibiting", "a", "potent", "symptomatic", "antimigraine", "effect", "."], "h": {"id": "C0528166", "name": "C0528166#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162757", "name": "C0162757#ent", "pos": [5, 6]}}
{"token": ["Regulation", "of", "the", "protein", "kinase", "C", "pathway", "phorbol", "myristate", "acetate", "PMA", ")", "stimulated", "SCG", "neuronal", "C1417815#ent", "<e1>", "secretion", "to", "a", "lesser", "degree", "than", "activation", "of", "C0010531#ent", "<e2>", "but", "did", "not", "alter", "cellular", "C1417815#ent", "<e1>", "levels", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [15, 16]}}
{"token": ["By", "using", "the", "immunogold", "technique", "we", "could", "distinguish", "two", "distinct", "types", "of", "C1414063#ent", "<e1>", "according", "to", "the", "IgA", "binding", "sites", "the", "C0277565#ent", "<e2>", "skin", "."], "h": {"id": "C1414063", "name": "C1414063#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [21, 22]}}
{"token": ["Recently", ",", "it", "has", "been", "demonstrated", "that", "RNA", "tethering", "of", "key", "C0127400#ent", "<e1>", "of", "NMD", ",", "including", "human", "C1426937#ent", "<e2>", ",", "accurately", "recreates", "NMD", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1426937", "name": "C1426937#ent", "pos": [18, 19]}}
{"token": ["We", "found", "no", "significant", "for", "age", "at", "onset", ",", "frequency", "and", "duration", "of", ",", "duration", "of", "the", "C0221166#ent", "<e1>", ",", "and", "occurrence", "of", "C0270860#ent", "<e2>", "symptoms", "."], "h": {"id": "C0221166", "name": "C0221166#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0270860", "name": "C0270860#ent", "pos": [23, 24]}}
{"token": ["An", "immunofluorometric", "assay", "C0281643#ent", "<e1>", ")", "has", "been", "developed", "for", "the", "potential", "C0003299#ent", "<e2>", "lamotrigine", "(", "Lamictal", ")", "."], "h": {"id": "C0281643", "name": "C0281643#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [12, 13]}}
{"token": ["The", "inhibitor", "had", "no", "effect", "C1565830#ent", "<e1>", "expression", ",", "indicating", "an", "involvement", "of", "C1418616#ent", "<e2>", "in", "PGE2", "synthesis", "."], "h": {"id": "C1565830", "name": "C1565830#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418616", "name": "C1418616#ent", "pos": [13, 14]}}
{"token": ["For", "uninfected", "people", ",", "the", "threat", "of", "the", "stigma", "associated", "with", "sexually", "transmitted", "infections", "C0036916#ent", "<e1>", ")", "is", "an", "integral", "tool", "of", "clinical", "and", "public", "health", "approaches", "C0019342#ent", "<e2>", "prevention", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0019342", "name": "C0019342#ent", "pos": [27, 28]}}
{"token": ["We", "assessed", "the", "diagnostic", "value", "CD8+", "levels", "in", "a", "larger", "group", "of", "patients", "with", "temporal", "arteritis", "polymyalgia", "rheumatica", "and", "after", "treatment", "with", "C0032950#ent", "<e1>", "and", "in", "relation", "to", "patients", "with", "other", "medical", "and", "C0009326#ent", "<e2>"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [22, 23]}, "relation": "may_treat", "t": {"id": "C0009326", "name": "C0009326#ent", "pos": [33, 34]}}
{"token": ["Plasma", "C0300252#ent", "<e1>", "PMCAs", ")", "are", "C0021699#ent", "<e2>", "actively", "expel", "Ca(2+)", "the", "cell", "."], "h": {"id": "C0300252", "name": "C0300252#ent", "pos": [1, 2]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}}
{"token": ["Basolateral", "Na+/Ca2+", "exchanger", "NCX", ")", "and", "plasma", "membrane", "Ca2+", "ATPase", "C0300252#ent", "<e1>", ")", "are", "the", "C0021699#ent", "<e2>", "export", "calcium", "Ca2", "+", ")", "from", "cells", "."], "h": {"id": "C0300252", "name": "C0300252#ent", "pos": [10, 11]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [15, 16]}}
{"token": ["Nucleophosmin", "(", "NPM", ",", "C1334894#ent", "<e1>", ")", "is", "an", "abundant", "C0069141#ent", "<e2>", "in", "ribosome", "biogenesis", "and", "interacts", "with", "tumor", "suppressor", "proteins", "p53", "Rb", "."], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0069141", "name": "C0069141#ent", "pos": [10, 11]}}
{"token": ["The", "human", "B23", "amino", "acid", "sequence", "98", "%", "homology", "with", "rat", "C1334894#ent", "<e1>", "and", "68", "%", "homology", "with", "the", "Xenopus", "laevis", "C0069141#ent", "<e2>", "NO38", "showing", "that", "the", "primary", "structure", "C1334894#ent", "<e1>", "is", "highly", "conserved", "among", "these", "species", "."], "h": {"id": "C1334894", "name": "C1334894#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0069141", "name": "C0069141#ent", "pos": [21, 22]}}
{"token": ["Interleukin-2", "(", "C1522405#ent", "<e1>", ")", "and", "IL-15", "are", "structurally", "related", "cytokines", "that", "share", "C1413696#ent", "<e2>", "display", "markedly", "different", "effects", "in", "multiple", "in", "vivo", "model", "systems"], "h": {"id": "C1522405", "name": "C1522405#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413696", "name": "C1413696#ent", "pos": [13, 14]}}
{"token": ["Although", "Epstein-Barr", "virus", "cause", "C0014070#ent", "<e1>", "the", "authors", "report", "a", "case", "of", "C0014059#ent", "<e2>", "months", "after", "acute", "Epstein-Barr", "virus", "infection"], "h": {"id": "C0014070", "name": "C0014070#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0014059", "name": "C0014059#ent", "pos": [12, 13]}}
{"token": ["Since", "administration", "of", "C0006456#ent", "<e1>", "did", "not", "inhibit", "hCG-sustained", "steroid", "levels", "in", "these", "C0062941#ent", "<e2>", "patients", ",", "it", "is", "conceivable", "that", "GnRH-A", "may", "have", "lacked", "a", "direct", "inhibitory", "gonadal", "effect", "such", "experimental", "conditions"], "h": {"id": "C0006456", "name": "C0006456#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0062941", "name": "C0062941#ent", "pos": [13, 14]}}
{"token": ["The", "C1418273#ent", "<e1>", "another", "conserved", "sequence", "motif", "first", "identified", "in", "the", "paired", "(", "C3887971#ent", "<e2>", ")", "and", "gooseberry", "(", "gsb", ")", "Drosophila", "homeo", "domain", "genes"], "h": {"id": "C1418273", "name": "C1418273#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3887971", "name": "C3887971#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "report", "that", "the", "function", "of", "C1334868#ent", "<e1>", "and", "RAM2", "genes", "is", "required", "for", "the", "membrane", "localization", "C0080058#ent", "<e2>", "a-factor", "."], "h": {"id": "C1334868", "name": "C1334868#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0080058", "name": "C0080058#ent", "pos": [18, 19]}}
{"token": ["To", "study", "hormonal", "regulation", "rat", "androgen-binding", "protein", "C1412100#ent", "<e1>", ")", "we", "have", "cloned", "and", "sequenced", "the", "C0017337#ent", "<e2>", "."], "h": {"id": "C1412100", "name": "C1412100#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["We", "have", "determined", "the", "effect", "of", "C0053490#ent", "<e1>", "and", "the", "azo", "dye", "sudan", "III", "on", "the", "level", "of", "C1136197#ent", "<e2>", "mRNA", "in", "a", "responsive", "rat", "hepatoma", "cell", "line"], "h": {"id": "C0053490", "name": "C0053490#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1136197", "name": "C1136197#ent", "pos": [18, 19]}}
{"token": ["For", "long", ",", "clonidine", "and", "C0724441#ent", "<e1>", "have", "been", "used", "for", "the", "treatment", "of", "hypertension", "and", "C0242350#ent", "<e2>", "respectively", ",", "but", "both", "have", "been", "superseded", "by", "newer", "drugs", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0242350", "name": "C0242350#ent", "pos": [16, 17]}}
{"token": ["We", "investigated", "whether", "a", "combination", "of", "long-term", "carnitine", "ingestion", "and", "exercise", "training", "reveals", "any", "interactive", "effects", "C0684153#ent", "<e1>", "FABPc", ")", "expression", "and", "C0000404#ent", "<e2>", "beta-HAD", ")", "activity", "in", "human", "skeletal", "muscle"], "h": {"id": "C0684153", "name": "C0684153#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0000404", "name": "C0000404#ent", "pos": [22, 23]}}
{"token": ["To", "determine", "the", "usefulness", "of", "cranial", "computed", "tomography", "C1413193#ent", "<e1>", ")", "in", "adults", "with", "a", "C0751110#ent", "<e2>", "we", "prospectively", "examined", "62", "such", "patients", "who", "were", "initially", "seen", "within", "24", "hours", "of", "the", "event", "."], "h": {"id": "C1413193", "name": "C1413193#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751110", "name": "C0751110#ent", "pos": [15, 16]}}
{"token": ["C1824728#ent", "<e1>", "C2", "are", "serine", "proteases", "provide", "the", "catalytic", "subunits", "C3", "and", "C1579593#ent", "<e2>", "the", "alternative", "(", "AP", ")", "and", "classical", "(", "CP", ")", "complement", "pathways"], "h": {"id": "C1824728", "name": "C1824728#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1579593", "name": "C1579593#ent", "pos": [12, 13]}}
{"token": ["For", "idiopathic", "generalized", "epilepsies", "absence", ",", "C0014549#ent", "<e1>", ",", "and", "myoclonic", "seizures", "the", "drug", "of", "choice", "is", "C0037567#ent", "<e2>", "."], "h": {"id": "C0014549", "name": "C0014549#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [17, 18]}}
{"token": ["Menkes'", "kinky", "hair", "disease", "Kinky", "hair", "disease", "C0205710#ent", "<e1>", ")", "is", "a", "rare", "C0019247#ent", "<e2>", "copper", "metabolism"], "h": {"id": "C0205710", "name": "C0205710#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [13, 14]}}
{"token": ["Although", "anemia", "is", "characteristic", "of", "chronic", "renal", "failure", "C1366488#ent", "<e1>", ")", ",", "leukopenia", "and", "C1839163#ent", "<e2>", "are", "not", "."], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "expression", "of", "human", "beta-defensin-2", "(", "HBD-2", ")", "mRNA", "in", "skin", "lesions", "patients", "with", "C1274323#ent", "<e1>", "RGH", ")", "and", "the", "effect", "of", "Huangbai", "Liquid", "(", "C1416867#ent", "<e2>", ")", "on", "it", "."], "h": {"id": "C1274323", "name": "C1274323#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [27, 28]}}
{"token": ["Eighteen", "patients", "had", "LRs", ",", "79", "showed", "C0796160#ent", "<e1>", "including", "18", "with", "urticaria", ",", "26", "had", "C0006266#ent", "<e2>", ",", "and", "35", "had", "anaphylactic", "shock"], "h": {"id": "C0796160", "name": "C0796160#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [16, 17]}}
{"token": ["In", "general", ",", "renal", "effects", "C0072973#ent", "<e1>", "were", "more", "pronounced", "in", "dogs", "C0342895#ent", "<e2>", "on", "low", "salt", "in", "those", "on", "normal", "diet"], "h": {"id": "C0072973", "name": "C0072973#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "whether", "secondary", "hyperparathyroidism", "HPTH", ")", "due", "to", "C0035579#ent", "<e1>", "bone", "mineral", "density", "BMD", ")", "response", "to", "C0700482#ent", "<e2>", "(", "ALN", ")", "in", "elderly", "women", "with", "osteoporosis", "."], "h": {"id": "C0035579", "name": "C0035579#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0700482", "name": "C0700482#ent", "pos": [18, 19]}}
{"token": ["The", "tissue-specific", "variation", "expanded", "C1567299#ent", "<e1>", "were", "apparent", "for", "mRNAs", "of", "all", "three", "C1417679#ent", "<e2>", "."], "h": {"id": "C1567299", "name": "C1567299#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["These", "data", "demonstrate", "that", "human", "alveolar", "macrophages", "able", "to", "express", "C0669372#ent", "<e1>", "support", "a", "role", "for", "this", "enzyme", "in", "C0032285#ent", "<e2>", "pathophysiology", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [19, 20]}}
{"token": ["Inhibition", "of", "C0669372#ent", "<e1>", "restores", "CYP2J4", "protein", "content", "and", "CYP", "activity", "in", "C0032285#ent", "<e2>", "indicating", "an", "important", "NO-CYP", "interaction", "in", "pulmonary", "responses", "infection", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}}
{"token": ["Diabetic", "nephropathy", "patients", ",", "whether", "insulin", "dependent", "or", "not", ",", "develop", "fibrotic", "changes", "in", "C0268731#ent", "<e1>", "that", "manifest", "as", "overt", "C0022658#ent", "<e2>", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [20, 21]}}
{"token": ["The", "latter", "can", "be", "divided", "into", "electrolyte", "disorders", "disorders", "of", "the", "water", "balance", "acute", "renal", "failure", "non-specific", "affections", "the", "C0268731#ent", "<e1>", ",", "tubules", "and", "renal", "vessels", "so-called", "C0022658#ent", "<e2>"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [27, 28]}}
{"token": ["Only", "the", "increase", "in", "C1705065#ent", "<e1>", "and", "caspase-3", "mRNAs", "caused", "by", "ischemia/reperfusion", "were", "unaffected", "by", "C0052929#ent", "<e2>", "treatment", "."], "h": {"id": "C1705065", "name": "C1705065#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0052929", "name": "C0052929#ent", "pos": [15, 16]}}
{"token": ["High", "MSI", "MSI-H", ")", "is", "significantly", "correlated", "with", "loss", "of", "either", "C1704807#ent", "<e1>", "or", "hMSH2", ",", "presence", "of", "C1704467#ent", "<e2>", ",", "and", "absence", "of", "p53", "."], "h": {"id": "C1704807", "name": "C1704807#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [18, 19]}}
{"token": ["Reverse", "transcriptase-polymerase", "chain", "reaction", "RT-PCR", ")", "and", "Southern", "blot", "analysis", "a", "C0381246#ent", "<e1>", "fusion", "transcript", "and", "C1334538#ent", "<e2>", "rearrangement", ",", "respectively", ",", "in", "all", "three", "cases", "."], "h": {"id": "C0381246", "name": "C0381246#ent", "pos": [11, 12]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1334538", "name": "C1334538#ent", "pos": [16, 17]}}
{"token": ["The", "combination", "of", "Lonafarnib", ",", "a", "C1517132#ent", "<e1>", "FTI", ")", "and", "C0915830#ent", "<e2>", "had", "additive", "and", "synergistic", "effects", "both", "FLT3/ITD", "positive", "and", "negative", "cell", "lines"], "h": {"id": "C1517132", "name": "C1517132#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0915830", "name": "C0915830#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "[3H]N-methylscopolamine", "binding", "revealed", "a", "C0026691#ent", "<e1>", "of", "0.2", "nM", "for", "C0301374#ent", "<e2>", "with", "a", "binding", "capacity", "of", "2500", "sites/cell", "."], "h": {"id": "C0026691", "name": "C0026691#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0301374", "name": "C0301374#ent", "pos": [12, 13]}}
{"token": ["No", "differences", "in", "the", "activity", "or", "excretion", "of", "either", "C0001057#ent", "<e1>", "or", "the", "inhibitory", "of", "the", "C0031640#ent", "<e2>", "observed", "between", "cyclic", "adenosine", "and", "control", "cells"], "h": {"id": "C0001057", "name": "C0001057#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [16, 17]}}
{"token": ["Various", "dihydropyridine", "Ca2", "C0870261#ent", "<e1>", "nimodipine", ",", "PCA50938", ",", "nifedipine", ",", "C0028127#ent", "<e2>", ",", "furnidipine", ")", "abolished", "the", "DMPP-mediated", "effects", ",", "but", "prevented", "only", "partially", "the", "activation", "by", "high", "[K+]0", "45Ca2", "+", "uptake", "."], "h": {"id": "C0870261", "name": "C0870261#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028127", "name": "C0028127#ent", "pos": [11, 12]}}
{"token": ["Exenatide", "is", "an", "incretin", "mimetic", "for", "the", "treatment", "of", "C0011860#ent", "<e1>", "combination", "with", "a", "sulfonylurea", ",", "a", "thiazolidinedione", ",", "C0025598#ent", "<e2>", ",", "or", "C0025598#ent", "<e2>", "plus", "a", "sulfonylurea", "or", "thiazolidinedione", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [19, 20]}}
{"token": ["C1335892#ent", "<e1>", "is", "necessary", "for", "the", "development", "of", "B", "cells", "epithelial", "gammadelta", "T", "cells", "whereas", "C1421567#ent", "<e2>", "is", "essential", "for", "the", "normal", "development", "T", "cells", "TCR", "signaling"], "h": {"id": "C1335892", "name": "C1335892#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421567", "name": "C1421567#ent", "pos": [15, 16]}}
{"token": ["Measures", "were", "constructed", "from", "C3539761#ent", "<e1>", "data", ",", "which", "are", "similar", "to", "C3273937#ent", "<e2>", "data", "."], "h": {"id": "C3539761", "name": "C3539761#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273937", "name": "C3273937#ent", "pos": [12, 13]}}
{"token": ["The", "initial", "uptakes", "of", "nicotinic", "acid", "the", "anion", "antiporter", "the", "proton", "cotransporter", "specifically", "inhibited", "by", "monocarboxylic", "acids", "as", "acetic", "acid", "benzoic", "acid", "D-", "and", "L-lactic", "acid", "C0085542#ent", "<e1>", "and", "valproic", "acid", "but", "not", "by", "di-", "or", "tricarboxylic", "acids", "bile", "acids", "C3539946#ent", "<e2>"], "h": {"id": "C0085542", "name": "C0085542#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [40, 41]}}
{"token": ["Uptake", "of", "[3H]mevalonic", "acid", "inhibited", "by", "various", "monocarboxylic", "acids", "including", "acetic", "acid", "benzoic", "acid", "lactic", "acid", "nicotinic", "acid", "C0085542#ent", "<e1>", ",", "salicylic", "acid", "valproic", "acid", "but", "not", "by", "dicarboxylic", "acid", "C3539946#ent", "<e2>"], "h": {"id": "C0085542", "name": "C0085542#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [30, 31]}}
{"token": ["While", "U.", "maydis", "wild-type", "cells", "were", "resistant", "to", "the", "C1333217#ent", "<e1>", "inhibitor", "brequinar", ",", "strains", "expressing", "the", "human", "C3887697#ent", "<e2>", "sensitive", "to", "this", "cytostatic", "drug"], "h": {"id": "C1333217", "name": "C1333217#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887697", "name": "C3887697#ent", "pos": [18, 19]}}
{"token": ["The", "exceptional", "compartmentation", "of", "the", "de", "novo", "synthesis", "with", "respect", "to", "C1333217#ent", "<e1>", "'", "DHOdehase", "'", "or", "'", "C3887697#ent", "<e2>", "'", ",", "EC", "1.3.99.11", ")", "is", "one", "focus", "of", "the", "present", "work", "."], "h": {"id": "C1333217", "name": "C1333217#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887697", "name": "C3887697#ent", "pos": [18, 19]}}
{"token": ["Previous", "reports", "have", "not", "discussed", "the", "diagnostic", "difficulties", "C0085222#ent", "<e1>", "the", "viewpoint", "of", "emergency", "physicians", "C1868684#ent", "<e2>", ")", ",", "especially", "in", "light", "of", "the", "widespread", "use", "of", "ED", "ultrasonography"], "h": {"id": "C0085222", "name": "C0085222#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1868684", "name": "C1868684#ent", "pos": [15, 16]}}
{"token": ["Both", "C3540772#ent", "<e1>", "catalyze", "endohydrolysis", "of", "C0007068#ent", "<e2>", "with", "the", "same", "pH", "optimum", "(", "5.5", "to", "6.0", ")", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007068", "name": "C0007068#ent", "pos": [6, 7]}}
{"token": ["The", "DA", "agonist", "C0003596#ent", "<e1>", "caused", "similar", "inhibitions", "of", "C3273356#ent", "<e2>", "release", "on", "days", "1", "and", "6", "after", "SS", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3273356", "name": "C3273356#ent", "pos": [9, 10]}}
{"token": ["Hereditary", "hemochromatosis", "HHC", ")", "is", "a", "late-onset", ",", "C3899988#ent", "<e1>", "to", "a", "chronic", "iron", "overload", "syndrome", "finally", "causing", "diabetes", ",", "cardiomyopathy", "and", "C0023895#ent", "<e2>"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [22, 23]}}
{"token": ["Choline", "acetyltransferase", "C0124604#ent", "<e1>", ")", "inhibitors", "related", "to", "trans-1-methyl-4-", "(1-naphthylvinyl)-pyridinium", "(", "C0132326#ent", "<e2>", ")", "have", "been", "assumed", "to", "depend", "upon", "a", "nearly", "or", "completely", "planar", "conformation", "their", "enzyme-inhibitor", "interaction", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0132326", "name": "C0132326#ent", "pos": [11, 12]}}
{"token": ["We", "measured", "the", "steady", "state", "of", "C0919451#ent", "<e1>", "mRNA", "in", "human", "cell", "lines", "were", "known", "to", "express", "C0027260#ent", "<e2>", "compared", "them", "to", "human", "cell", "lines", "have", "not", "been", "identified", "with", "ras", "activation", "."], "h": {"id": "C0919451", "name": "C0919451#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027260", "name": "C0027260#ent", "pos": [17, 18]}}
{"token": ["We", "report", "here", "a", "case", "of", "C0343398#ent", "<e1>", ",", "to", "increase", "awareness", "of", "possibility", "of", "C4303102#ent", "<e2>", "patients", "with", "prolonged", "diarrhoea", "."], "h": {"id": "C0343398", "name": "C0343398#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4303102", "name": "C4303102#ent", "pos": [15, 16]}}
{"token": ["The", "human", "pathogen", "Enterococcus", "faecalis", "degrade", "the", "N-linked", "glycans", "of", "human", "C0073234#ent", "<e1>", "acquire", "nutrients", ",", "but", "no", "C0017337#ent", "<e2>", "or", "protein", "has", "been", "associated", "with", "activity", "."], "h": {"id": "C0073234", "name": "C0073234#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["Additive", "interactions", "found", "for", "C0110893#ent", "<e1>", "and", "C0752310#ent", "<e2>", "in", "the", "tail", "flick", "assay", ",", "and", "C0752310#ent", "<e2>", "and", "morphine", "in", "both", "assays", "."], "h": {"id": "C0110893", "name": "C0110893#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752310", "name": "C0752310#ent", "pos": [7, 8]}}
{"token": ["The", "C0729233#ent", "<e1>", "patent", "and", "there", "was", "no", "evidence", "of", "C0016085#ent", "<e2>", "."], "h": {"id": "C0729233", "name": "C0729233#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0016085", "name": "C0016085#ent", "pos": [10, 11]}}
{"token": ["Toll-like", "receptor", "9", "TLR9", ")", "C2987634#ent", "<e1>", "such", "as", "unmethylated", "bacterial", "CpG", "C0011522#ent", "<e2>", "activate", "B", "lymphocytes", ",", "potentially", "influencing", "their", "function", "and", "homeostasis", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [12, 13]}}
{"token": ["In", "our", "study", ",", "the", "application", "of", "5-Aminolevulinic", "acid", "5-ALA", ")", ",", "a", "precursor", "in", "the", "heme", "biosynthesis", "pathway", "led", "to", "Protoporphyrin", "IX", "C1121290#ent", "<e1>", ")", "accumulation", "within", "the", "parathyroid", "gland", "C0039512#ent", "<e2>", ")", "."], "h": {"id": "C1121290", "name": "C1121290#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0039512", "name": "C0039512#ent", "pos": [31, 32]}}
{"token": ["Elderly", "Melanesian", "villagers", "are", "physically", "active", "and", "it", "appears", "that", "this", "is", "an", "important", "factor", "in", "preventing", "C3714552#ent", "<e1>", "associated", "fractures", "of", "the", "C1709823#ent", "<e2>", "and", "distal", "radius"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1709823", "name": "C1709823#ent", "pos": [23, 24]}}
{"token": ["The", "results", "are", "discussed", "in", "relation", "to", "how", "this", "economical", "and", "straightforward", "transfection", "procedure", "be", "useful", "in", "identify", "factors", "regulating", "the", "transcription", "of", "C1332763#ent", "<e1>", "and", "other", "C0017337#ent", "<e2>", "expressed", "in", "neuronal", "cells"], "h": {"id": "C1332763", "name": "C1332763#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [27, 28]}}
{"token": ["Orbital", "complications", "acute", "sinusitis", "classified", "into", "inflammatory", "edema", "C0149507#ent", "<e1>", "subperiostal", "abscess", "and", "C0000833#ent", "<e2>"], "h": {"id": "C0149507", "name": "C0149507#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [13, 14]}}
{"token": ["Imaging", "studies", "C0149507#ent", "<e1>", "paranasal", "sinusitis", "and", "a", "large", "C0000833#ent", "<e2>", "the", "left", "frontal", "lobe"], "h": {"id": "C0149507", "name": "C0149507#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [9, 10]}}
{"token": ["Sometimes", "the", "infection", "causes", "C0149507#ent", "<e1>", "rarely", "an", "C0000833#ent", "<e2>"], "h": {"id": "C0149507", "name": "C0149507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0000833", "name": "C0000833#ent", "pos": [8, 9]}}
{"token": ["A", "C0072476#ent", "<e1>", "phosphorylation", "site", "was", "also", "identified", "within", "the", "amino-terminal", "domain", "C3891713#ent", "<e2>", "."], "h": {"id": "C0072476", "name": "C0072476#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3891713", "name": "C3891713#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "increase", "of", "cyclic", "GMP", "production", "stimulated", "by", "sodium", "nitroprusside", "an", "C1422492#ent", "<e1>", "of", "soluble", "guanylate", "cyclase", "was", "not", "inhibited", "by", "halothane", "or", "C0022180#ent", "<e2>", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [25, 26]}}
{"token": ["Conversely", ",", "C3889135#ent", "<e1>", "is", "catalytically", "invariant", "toward", "C1418262#ent", "<e2>", "and", "synaptotagmin", "VII"], "h": {"id": "C3889135", "name": "C3889135#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418262", "name": "C1418262#ent", "pos": [8, 9]}}
{"token": ["In", "patients", "with", "C0020443#ent", "<e1>", "the", "combination", "of", "atorvastatin", "and", "C0009279#ent", "<e2>", "tended", "to", "produce", "larger", "reductions", "in", "LDL-cholesterol", "levels", "and", "smaller", "reductions", "in", "triglyceride", "levels", "than", "atorvastatin", "monotherapy", "."], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0009279", "name": "C0009279#ent", "pos": [10, 11]}}
{"token": ["Our", "further", "study", "indicated", "that", "C0026056#ent", "<e1>", "changed", "C1414919#ent", "<e2>", "affinity", "to", "GABA", "and", "the", "effects", "of", "C0026056#ent", "<e1>", "on", "I(GABA", ")", "were", "voltage-independent", "."], "h": {"id": "C1414919", "name": "C1414919#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026056", "name": "C0026056#ent", "pos": [5, 6]}}
{"token": ["The", "deduced", "amino", "acid", "sequence", "that", "THR", "protein", "THRP", ")", ",", "a", "68", "kDa", "moiety", ",", "has", "83", "%", "sequence", "similarity", "C0080064#ent", "<e1>", "Abi-2", ")", ",", "which", "is", "a", "substrate", "for", "tyrosine", "kinase", "activity", "C1704928#ent", "<e2>", "."], "h": {"id": "C0080064", "name": "C0080064#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1704928", "name": "C1704928#ent", "pos": [34, 35]}}
{"token": ["In", "a", "yeast", "two-hybrid", "experiment", "using", "the", "C1417585#ent", "<e1>", "ZNF202", "as", "bait", ",", "we", "previously", "identified", "the", "SCAN-domain-containing", "protein", "C1423100#ent", "<e2>", "."], "h": {"id": "C1417585", "name": "C1417585#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423100", "name": "C1423100#ent", "pos": [19, 20]}}
{"token": ["Activities", "of", "glutathione", "redox", "cycle", "C0014442#ent", "<e1>", "did", "not", "differ", "significantly", "between", "mitochondria", "from", "control", "and", "C3889647#ent", "<e2>", "rats", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889647", "name": "C3889647#ent", "pos": [16, 17]}}
{"token": ["When", "sperm", "bind", "to", "the", "zona", "pellucida", "C1421866#ent", "<e1>", "induces", "the", "acrosome", "reaction", "aggregating", "C0002272#ent", "<e2>", "."], "h": {"id": "C1421866", "name": "C1421866#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [14, 15]}}
{"token": ["Discussed", "here", "are", "recent", "advances", "that", "point", "to", "a", "definitive", "role", "during", "C0567085#ent", "<e1>", "development", "and", "adult", "function", "for", "one", "member", "of", "the", "C0935995#ent", "<e2>", "Wnt-7a", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0935995", "name": "C0935995#ent", "pos": [23, 24]}}
{"token": ["The", "C1335230#ent", "<e1>", "originally", "designated", "as", "the", "structural", "gene", "C0035679#ent", "<e2>", "on", "the", "absence", "of", "detectable", "C0035679#ent", "<e2>", "in", "cell", "lysates", "from", "a", "strain", "containing", "the", "mutant", "polB100", "allele", "."], "h": {"id": "C1335230", "name": "C1335230#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [9, 10]}}
{"token": ["Accordingly", ",", "when", "the", "therapy", "is", "started", ",", "the", "most", "frequent", "side", "effects", "worsening", "C0018801#ent", "<e1>", "metoprolol", "and", "bisoprolol", "and", "hypotension", "and", "dizziness", "with", "C1815010#ent", "<e2>", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C1815010", "name": "C1815010#ent", "pos": [24, 25]}}
{"token": ["The", "first", "one", "aimed", "at", "determining", "the", "appropriate", "dose", "of", "heated", "(", "42", "degrees", "C", ")", "intraperitoneal", "C0069717#ent", "<e1>", "following", "complete", "resection", "of", "peritoneal", "carcinomatosis", "C1418943#ent", "<e2>", ")", "by", "studying", "its", "pharmacokinetics", "."], "h": {"id": "C0069717", "name": "C0069717#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [25, 26]}}
{"token": ["To", "evaluate", "the", "safety", "and", "explore", "the", "efficacy", "of", "C1739462#ent", "<e1>", "(", "recombinant", "human", "iduronate-2-sulfatase", "treatment", "for", "mucopolysaccharidosis", "II", "C0026705#ent", "<e2>", "."], "h": {"id": "C1739462", "name": "C1739462#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0026705", "name": "C0026705#ent", "pos": [19, 20]}}
{"token": ["Interestingly", ",", "C1566790#ent", "<e1>", "and", "Smad3", "play", "opposite", "roles", "in", "regulating", "C1335828#ent", "<e2>", "expression", "in", "both", "fibroblasts", "and", "epithelial", "cells"], "h": {"id": "C1566790", "name": "C1566790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335828", "name": "C1335828#ent", "pos": [11, 12]}}
{"token": ["Biochemical", "evidence", "and", "genetic", "epistasis", "analyses", "that", "C1566790#ent", "<e1>", "acts", "upstream", "of", "C1335828#ent", "<e2>", "in", "a", "shared", "pathway", "with", "Cdh1-APC", "in", "the", "control", "of", "axonal", "growth"], "h": {"id": "C1566790", "name": "C1566790#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335828", "name": "C1335828#ent", "pos": [12, 13]}}
{"token": ["To", "explore", "the", "relationship", "between", "hereditary", "motor", "C0699739#ent", "<e1>", "HMSN", ")", "and", "C0026650#ent", "<e2>", "we", "examined", "7", "patients", "with", "HMSN", "referred", "to", "our", "Movement", "Disorders", "Clinic", "surveyed", "members", "of", "the", "Charcot-Marie-Tooth", "association", "."], "h": {"id": "C0699739", "name": "C0699739#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [12, 13]}}
{"token": ["These", "effects", "of", "C0168853#ent", "<e1>", "were", "somewhat", "more", "potent", "than", "those", "of", "C0022642#ent", "<e2>", "."], "h": {"id": "C0168853", "name": "C0168853#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022642", "name": "C0022642#ent", "pos": [12, 13]}}
{"token": ["The", "inhibitory", "effect", "of", "C0168853#ent", "<e1>", "was", "more", "potent", "than", "those", "of", "C0022642#ent", "<e2>", "and", "terfenadine", "."], "h": {"id": "C0168853", "name": "C0168853#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022642", "name": "C0022642#ent", "pos": [12, 13]}}
{"token": ["Nonsteroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", "such", "as", "tolfenamic", "acid", "C0546873#ent", "<e2>", "with", "sumatriptan", "have", "demonstrated", "efficacy", "in", "reducing", "recurrence", "observed", "with", "the", "single", "use", "of", "this", "drug", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C0546873", "name": "C0546873#ent", "pos": [10, 11]}}
{"token": ["Similar", "to", "mammalian", "C0169101#ent", "<e1>", "this", "modification", "occurs", "at", "two", "C3539947#ent", "<e2>", "FUS3", ",", "threonine-180", "and", "tyrosine-182", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [10, 11]}}
{"token": ["These", "include", "C1279945#ent", "<e1>", "dermatomyositis", ",", "pulmonary", "interstitial", "fibrosis", "scleroderma", ",", "and", "C0852879#ent", "<e2>"], "h": {"id": "C1279945", "name": "C1279945#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0852879", "name": "C0852879#ent", "pos": [12, 13]}}
{"token": ["In", "vitro", "the", "geldanamycin", "derivate", "C1743502#ent", "<e1>", "(", "17-AAG", ")", "led", "to", "marked", "reduction", "in", "C0907533#ent", "<e2>", "and", "inducible", "activation", "of", "extracellular", "signal-regulated", "kinase", "1/2", "Akt", ",", "and", "signal", "transducer", "activator", "of", "transcription", "3", "decreased", "nuclear", "HIF-1alpha", "protein"], "h": {"id": "C1743502", "name": "C1743502#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "changes", "in", "cell", "growth", "C0024776#ent", "<e1>", "BCKD", ")", "activity", "by", "varying", "the", "concentrations", "of", "branched-chain", "amino", "acids", "C1423571#ent", "<e2>", ")", "in", "culture", "medium", "diploid", "fibroblasts", "humans", "with", "normal", "BCKD", "and", "with", "impaired", "enzyme", "function"], "h": {"id": "C0024776", "name": "C0024776#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423571", "name": "C1423571#ent", "pos": [19, 20]}}
{"token": ["The", "C0009782#ent", "<e1>", "are", "discussed", "are", "C0409974#ent", "<e2>", "scleroderma", ",", "and", "dermatomyositis", "."], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0409974", "name": "C0409974#ent", "pos": [6, 7]}}
{"token": ["Both", "the", "opioid", "and", "C0019592#ent", "<e1>", "were", "tested", "in", "combination", "with", "C0003596#ent", "<e2>", "and", "haloperidol", "."], "h": {"id": "C0019592", "name": "C0019592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003596", "name": "C0003596#ent", "pos": [11, 12]}}
{"token": ["Collectively", ",", "these", "results", "provide", "evidence", "that", "C1706331#ent", "<e1>", "stimulation", "protects", "the", "mitochondria", "from", "dysfunction", "induced", "by", "C1413043#ent", "<e2>", "+", "loading", ",", "and", "inhibits", "mitochondrial", "pathways", "apoptosis", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [17, 18]}}
{"token": ["Of", "these", ",", "C0032896#ent", "<e1>", ",", "phentolamine", ",", "practolol-phentolamine", ",", "phentolamine-practolol", ",", "promethazine", ",", "C0062637#ent", "<e2>", ",", "procainamide", "and", "verapamil", "were", "unacceptable", "."], "h": {"id": "C0032896", "name": "C0032896#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0062637", "name": "C0062637#ent", "pos": [14, 15]}}
{"token": ["Autonomic", "and", "C0151313#ent", "<e1>", "also", "observed", "in", "C0023896#ent", "<e2>"], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023896", "name": "C0023896#ent", "pos": [7, 8]}}
{"token": ["Cytochrome", "P450", "CYP", ")", "2C9", ",", "the", "product", "of", "the", "polymorphic", "gene", "C1828473#ent", "<e1>", ",", "provides", "the", "major", "catabolic", "pathway", "several", "anti-inflammatory", "drugs", "including", "C0076096#ent", "<e2>", "."], "h": {"id": "C1828473", "name": "C1828473#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0076096", "name": "C0076096#ent", "pos": [24, 25]}}
{"token": ["C1426113#ent", "<e1>", "and", "Rap2", "are", "similar", "C0812284#ent", "<e2>", "perform", "distinct", "functions", "."], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812284", "name": "C0812284#ent", "pos": [6, 7]}}
{"token": ["Because", "serum", "paraoxonase", "activity", "is", "influenced", "by", "the", "-108C/T", "polymorphism", "in", "the", "PON1", "gene", "we", "studied", "its", "involvement", "in", "the", "decreased", "C0163401#ent", "<e1>", "activity", "recently", "described", "in", "the", "C0032460#ent", "<e2>", "PCOS", ")", "."], "h": {"id": "C0163401", "name": "C0163401#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [28, 29]}}
{"token": ["Exposure", "of", "human", "monocytes", "to", "C0339959#ent", "<e1>", "in", "a", "significant", "enhancement", "of", "matrix", "metalloproteinase", "C0919336#ent", "<e2>", ")", "1", "and", "9", "production", "following", "stimulation", "with", "tumor", "necrosis", "factor", "alpha", "granulocyte", "monocyte-colony", "stimulating", "factor"], "h": {"id": "C0339959", "name": "C0339959#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [14, 15]}}
{"token": ["C0162565#ent", "<e1>", "AIP", ")", "is", "a", "C0015398#ent", "<e2>", "biochemically", "by", "a", "defect", "in", "the", "heme", "pathway", "enzyme", "porphobilinogen", "deaminase"], "h": {"id": "C0162565", "name": "C0162565#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015398", "name": "C0015398#ent", "pos": [6, 7]}}
{"token": ["In", "this", "study", ",", "we", "have", "tested", "whether", "ursodeoxycholic", "acid", "ameliorates", "C0014335#ent", "<e1>", "induced", "by", "C0021246#ent", "<e2>", "in", "rats", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [15, 16]}}
{"token": ["C3273832#ent", "<e1>", "stimulates", "the", "activity", "of", "C1122828#ent", "<e2>", "in", "vitro", "excising", "5-hydroxyuracil", "from", "duplex", ",", "bubble", ",", "forked", ",", "and", "single-stranded", "DNA", "substrates", "up", "to", "5-fold", "."], "h": {"id": "C3273832", "name": "C3273832#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1122828", "name": "C1122828#ent", "pos": [6, 7]}}
{"token": ["The", "protein", "showed", "weak", "homology", "to", "the", "C1621701#ent", "<e1>", "the", "amino-terminal", "side", "to", "the", "C1412719#ent", "<e2>", "the", "carboxyl-terminal", "side"], "h": {"id": "C1621701", "name": "C1621701#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412719", "name": "C1412719#ent", "pos": [14, 15]}}
{"token": ["Abnormal", "portal", "vessels", "small", "portal", "tracts", "be", "seen", "in", "association", "with", "various", "causes", "of", "C0020541#ent", "<e1>", "such", "as", "C4310735#ent", "<e2>", "NCPH", ")", "and", "cirrhosis", "."], "h": {"id": "C0020541", "name": "C0020541#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C4310735", "name": "C4310735#ent", "pos": [18, 19]}}
{"token": ["The", "great", "majority", "of", "men", "afflicted", "by", "C0030794#ent", "<e1>", "of", "additional", "C1457887#ent", "<e2>", "particularly", "back", "and", "joint", "pain", "and", "fatigue", "."], "h": {"id": "C0030794", "name": "C0030794#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [11, 12]}}
{"token": ["Collectively", ",", "our", "results", "demonstrate", "a", "novel", "mechanism", "of", "signal", "termination", "by", "the", "Rho-family", "C0018296#ent", "<e1>", "Chp", "and", "C0082645#ent", "<e2>", ",", "which", "results", "in", "ubiquitin-mediated", "degradation", "one", "of", "their", "direct", "effectors", "Pak1", "."], "h": {"id": "C0018296", "name": "C0018296#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [18, 19]}}
{"token": ["Old", "age", "male", "gender", ",", "duration", "of", "haemodialysis", ",", "C0085682#ent", "<e1>", "associated", "with", "hypoparathyroidism", "and", "raised", "C3265062#ent", "<e2>", "predisposing", "factors"], "h": {"id": "C0085682", "name": "C0085682#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3265062", "name": "C3265062#ent", "pos": [16, 17]}}
{"token": ["In", "both", "cases", ",", "the", "coadministration", "of", "the", "C2927149#ent", "<e1>", "with", "the", "C3889128#ent", "<e2>", "or", "D2", "agonist", "induced", "contralateral", "rotation"], "h": {"id": "C2927149", "name": "C2927149#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [12, 13]}}
{"token": ["Topical", "5", "C0026196#ent", "<e1>", "used", "to", "treat", "47", "patients", "with", "severe", "C0002170#ent", "<e2>"], "h": {"id": "C0026196", "name": "C0026196#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [11, 12]}}
{"token": ["Consequently", ",", "C0026196#ent", "<e1>", "been", "developed", "to", "try", "to", "improve", "hair", "growth", "patients", "with", "C0002170#ent", "<e2>", "alopecia", "androgenetica", "."], "h": {"id": "C0026196", "name": "C0026196#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0002170", "name": "C0002170#ent", "pos": [14, 15]}}
{"token": ["We", "distinguished", "JNK-2", "as", "responsible", "for", "C1417695#ent", "<e1>", "cytoplasmic", "retention", "by", "PEDF", "and", "JNK-1", "and", "JNK-2", "as", "C0127400#ent", "<e2>", "of", "PEDF-driven", "NFAT", "nuclear", "export"], "h": {"id": "C1417695", "name": "C1417695#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [17, 18]}}
{"token": ["C1418825#ent", "<e1>", "is", "also", "phosphorylated", "on", "Ser-137", "by", "C3272787#ent", "<e2>", "CK1", ")", ",", "in", "vitro", "in", "vivo"], "h": {"id": "C1418825", "name": "C1418825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272787", "name": "C3272787#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "determined", "the", "distribution", "of", "the", "PcG", "proteins", "C3811118#ent", "<e1>", ",", "E(Z", ")", "and", "PSC", "and", "of", "trimethylation", "of", "C3898881#ent", "<e2>", "me3K27", ")", "in", "the", "D.", "melanogaster", "genome", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3898881", "name": "C3898881#ent", "pos": [21, 22]}}
{"token": ["We", "present", "here", "a", "case", "of", "Sj\u00f6gren's", "syndrome", "SjS", ")", "with", "C3887650#ent", "<e1>", "based", "on", "C0268435#ent", "<e2>", "RTA-1", ")", "."], "h": {"id": "C3887650", "name": "C3887650#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268435", "name": "C0268435#ent", "pos": [15, 16]}}
{"token": ["Mean", "TF", ",", "TF", "activity", ",", "C1420705#ent", "<e1>", ",", "and", "FVIIa", "significantly", "increased", "among", "C0020473#ent", "<e2>", "compared", "with", "normolipidemic", "diabetic", "patients", ",", "and", "normolipidemic", "diabetic", "patients", "compared", "with", "controls", "."], "h": {"id": "C1420705", "name": "C1420705#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020473", "name": "C0020473#ent", "pos": [14, 15]}}
{"token": ["The", "study", "of", "hematopoietic", "stem", "cell", "function", "C0030312#ent", "<e1>", "hints", "for", "specific", "molecular", "pathways", "disturbed", "in", "many", "C0029896#ent", "<e2>", "of", "hematopoietic", "and", "non-hematopoietic", "stem", "cells"], "h": {"id": "C0030312", "name": "C0030312#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "indicate", "that", "C1428063#ent", "<e1>", "could", "be", "a", "promising", "strategy", "for", "cell", "therapy", "C0027765#ent", "<e2>", "could", "be", "employed", "in", "other", "situations", "with", "fetal", "cell", "transplants", "or", "with", "stem", "cells"], "h": {"id": "C1428063", "name": "C1428063#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "C1417093#ent", "<e1>", "knockdown", "affected", "only", "C1418724#ent", "<e2>", "flux", "of", "the", "pyruvate", "derived", "from", "glutamate", "metabolism"], "h": {"id": "C1417093", "name": "C1417093#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418724", "name": "C1418724#ent", "pos": [8, 9]}}
{"token": ["The", "degree", "of", "AP", "damage", "C0014060#ent", "<e1>", "was", "represented", "as", "the", "slope", "of", "the", "time-activity", "curve", "the", "C0058836#ent", "<e2>", "."], "h": {"id": "C0014060", "name": "C0014060#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0058836", "name": "C0058836#ent", "pos": [17, 18]}}
{"token": ["In", "Belgium", ",", "non-typhoidal", "salmonellosis", "and", "C0275982#ent", "<e1>", "are", "the", "two", "most", "frequently", "reported", "foodborne", "C0221423#ent", "<e2>", "."], "h": {"id": "C0275982", "name": "C0275982#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [15, 16]}}
{"token": ["C0029411#ent", "<e1>", "a", "clinical", "and", "radiological", "syndrome", "by", "proliferation", "of", "C0151846#ent", "<e2>", "in", "long", "bones", "digital", "clubbing"], "h": {"id": "C0029411", "name": "C0029411#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0151846", "name": "C0151846#ent", "pos": [10, 11]}}
{"token": ["The", "genes", "were", ":", "SHP1", ",", "a", "protein", "tyrosine", "phosphatase", "C0134982#ent", "<e1>", ",", "a", "protein", "kinase", "and", "C1426208#ent", "<e2>", ",", "a", "suppressor", "of", "cytokine", "signaling"], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1426208", "name": "C1426208#ent", "pos": [17, 18]}}
{"token": ["Atomoxetine", "is", "a", "potent", "and", "selective", "norepinephrine", "transporter", "NET", ")", "C0162758#ent", "<e1>", "as", "a", "C0304402#ent", "<e2>", "for", "the", "treatment", "of", "attention-deficit/hyperactivity", "disorder", "ADHD", ")", "."], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [14, 15]}}
{"token": ["In", "vitro", "studies", "suggest", "that", "macrophage", "C0017205#ent", "<e1>", "storage", "leads", "to", "tissue", "dysfunction", "complex", "mechanisms", "involving", "altered", "intracellular", "C3653518#ent", "<e2>", "apoptosis", "."], "h": {"id": "C0017205", "name": "C0017205#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3653518", "name": "C3653518#ent", "pos": [18, 19]}}
{"token": ["The", "effects", "of", "pretreatment", "with", "varying", "doses", "of", "C0143993#ent", "<e1>", "on", "the", "subsequent", "induction", "of", "anaesthesia", "with", "thiopentone", ",", "C0025668#ent", "<e2>", "or", "midazolam", "were", "studied", "in", "240", "healthy", "patients", "."], "h": {"id": "C0143993", "name": "C0143993#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025668", "name": "C0025668#ent", "pos": [19, 20]}}
{"token": ["Moreover", ",", "apoptosis", "induction", "by", "VD3", "was", "suppressed", "by", "overexpressing", "Bcl-2", ",", "a", "known", "C0001645#ent", "<e1>", "of", "cytochrome", "c", ",", "whereas", "the", "C0667830#ent", "<e2>", "CrmA", "afforded", "little", "protection", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0667830", "name": "C0667830#ent", "pos": [22, 23]}}
{"token": ["Since", "tubular", "MAC", "deposited", "in", "inflamed", "areas", "of", "C0027707#ent", "<e1>", ",", "we", "propose", "that", "C4049728#ent", "<e2>", "might", "contribute", "to", "the", "development", "of", "tubulointerstitial", "inflammatory", "processes", "in", "human", "glomerulopathies"], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4049728", "name": "C4049728#ent", "pos": [14, 15]}}
{"token": ["In", "C4282434#ent", "<e1>", "flutamide", "potentiated", "the", "expression", "of", "the", "four", "PKC", "C0022173#ent", "<e2>", "in", "almost", "all", "conditions", "tested", "(", "FBS-", "and", "CSS-cultured", "cells", ")", "."], "h": {"id": "C4282434", "name": "C4282434#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [11, 12]}}
{"token": ["C1421452#ent", "<e1>", "transduces", "human", "T-cell", "chemotaxis", ",", "expression", "of", "C0127082#ent", "<e2>", "MMPs", ")", "2", "and", "9", "and", "consequently", "basement", "membrane", "connective", "tissue", "transmigration", ",", "while", "signaling", "suppression", "proliferation", "and", "cytokine", "production", "."], "h": {"id": "C1421452", "name": "C1421452#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [9, 10]}}
{"token": ["C1413502#ent", "<e1>", "is", "a", "ubiquitous", ",", "C0536221#ent", "<e2>", "functions", "in", "cell", "volume", "regulation", "RNA", "processing", ",", "and", "is", "thus", "part", "of", "an", "intricate", "protein", "network", "involved", "in", "the", "homoeostasis", "of", "cells", "."], "h": {"id": "C1413502", "name": "C1413502#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [6, 7]}}
{"token": ["The", "properties", "of", "the", "nicotinic", "currents", "in", "C1413269#ent", "<e1>", "neurons", "were", "similar", "to", "those", "of", "type", "IA", "elicited", "by", "C0242948#ent", "<e2>", "rat", "hippocampal", "neurons", "."], "h": {"id": "C1413269", "name": "C1413269#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242948", "name": "C0242948#ent", "pos": [19, 20]}}
{"token": ["In", "co-immunoprecipitation", "experiments", ",", "C1421933#ent", "<e1>", "was", "found", "to", "be", "associated", "with", "Cdk2", ",", "cyclin", "E", "and", "C1332694#ent", "<e2>", "but", "not", "the", "Cdc2/cyclin", "B", "complex", "in", "Xenopus", "egg", "extracts", "."], "h": {"id": "C1421933", "name": "C1421933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332694", "name": "C1332694#ent", "pos": [17, 18]}}
{"token": ["We", "demonstrate", "that", "C1336596#ent", "<e1>", "potentiates", "SREBP-1c-mediated", "adiponectin", "promoter", "activation", "and", "that", "C1415856#ent", "<e2>", "can", "dose-dependently", "inhibit", "this", "action", "via", "interaction", "with", "C1336596#ent", "<e1>", "."], "h": {"id": "C1415856", "name": "C1415856#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [3, 4]}}
{"token": ["This", "randomized", ",", "placebo-controlled", "trial", "designed", "to", "assess", "the", "efficacy", "and", "safety", "of", "therapy", "with", "C1332791#ent", "<e1>", "GM-CSF", ")", "and", "erythropoietin", "(", "C0357126#ent", "<e2>", "in", "anemic", ",", "neutropenic", "patients", "with", "myelodysplastic", "syndrome"], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0357126", "name": "C0357126#ent", "pos": [22, 23]}}
{"token": ["Other", "manganese-containing", "enzymes", "include", "oxidoreductases", ",", "C0040676#ent", "<e1>", ",", "hydrolases", ",", "lyases", ",", "isomerases", ",", "ligases", "and", "C0017801#ent", "<e2>"], "h": {"id": "C0040676", "name": "C0040676#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017801", "name": "C0017801#ent", "pos": [17, 18]}}
{"token": ["Finally", ",", "the", "impact", "of", "C1428880#ent", "<e1>", "disruption", "on", "secretion", "of", "three", "recombinant", "model", "proteins", "P.", "pastoris", ",", "C0103396#ent", "<e2>", "human", "serum", "albumin", "Rhizopus", "oryzae", "lipase", "was", "evaluated", "."], "h": {"id": "C1428880", "name": "C1428880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0103396", "name": "C0103396#ent", "pos": [18, 19]}}
{"token": ["C1420726#ent", "<e1>", "EC", "3.4.24.15", ";", "EP24.15", ")", "is", "a", "C0025543#ent", "<e2>", "distributed", "in", "mammalian", "tissues", "and", "involved", "in", "oligopeptide", "metabolism", "within", "and", "outside", "cells", "."], "h": {"id": "C1420726", "name": "C1420726#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [9, 10]}}
{"token": ["Still", ",", "the", "true", "extent", "of", "the", "problem", "and", "the", "relative", "frequency", "infection", "with", "C0036472#ent", "<e1>", "compared", "to", "murine", "C0041471#ent", "<e2>", "are", "unknown", "."], "h": {"id": "C0036472", "name": "C0036472#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0041471", "name": "C0041471#ent", "pos": [19, 20]}}
{"token": ["Genital", "herpes", "simplex", "virus", "C0019348#ent", "<e1>", ")", "infection", ",", "a", "C0036916#ent", "<e2>", "STD", ")", ",", "is", "the", "commonest", "cause", "of", "ulcerative", "genital", "infections", "among", "the", "young", "and", "adult", "population", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0036916", "name": "C0036916#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "an", "C0014442#ent", "<e1>", "that", "hydrolyzed", "C0001019#ent", "<e2>", "was", "partially", "purified", ";", "it", "was", "induced", "about", "3.5-fold", "by", "di(2-ethylhexyl)phthalate", "treatment", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001019", "name": "C0001019#ent", "pos": [8, 9]}}
{"token": ["The", "C1418776#ent", "<e1>", "mechanisms", "that", "mediate", "the", "steroidogenic", "actions", "of", "angiotensin", "II", "C2698414#ent", "<e2>", ")", "have", "been", "characterized", "in", "rat", "and", "bovine", "adrenal", "glomerulosa", "cells"], "h": {"id": "C1418776", "name": "C1418776#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [12, 13]}}
{"token": ["Primary", "diagnosis", "refractory", "trigeminal", "neuralgia", ",", "atypical", "headaches", "C0178782#ent", "<e1>", "posttraumatic", "closed", "head", "injuries", "postsurgical", "anesthesia", "dolorosa", ",", "multiple", "sclerosis", "brainstem", "infarction", "postherpetic", "neuralgia", "C0280950#ent", "<e2>"], "h": {"id": "C0178782", "name": "C0178782#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0280950", "name": "C0280950#ent", "pos": [24, 25]}}
{"token": ["The", "efficacy", "of", "nebulized", "glycopyrrolate", "compared", "with", "C0025573#ent", "<e1>", "was", "evaluated", "in", "46", "patients", "with", "C0004096#ent", "<e2>"], "h": {"id": "C0025573", "name": "C0025573#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}}
{"token": ["Iron", "deficiency", "C0002873#ent", "<e1>", "two", "subtypes", "of", "insidious", "C0002871#ent", "<e2>", "that", "may", "be", "difficult", "to", "differentiate", "."], "h": {"id": "C0002873", "name": "C0002873#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [8, 9]}}
{"token": ["5-HT-induced", "contractions", "in", "vessels", "from", "C0020550#ent", "<e1>", "rats", "were", "diminished", "by", "prior", "incubation", "with", "C0021246#ent", "<e2>", "(", "10", "microM", ")", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [14, 15]}}
{"token": ["Tissue", "sections", "obtained", "by", "liver", "biopsy", "25", "patients", "with", "HBV-associated", "chronic", "C0023895#ent", "<e1>", "were", "examined", "by", "immunohistochemistry", "using", "anti-CD34", ",", "anti-von", "Willebrand", "factor", "C1336938#ent", "<e2>", ")", ",", "and", "anti-vascular", "endothelial", "growth", "factor", "VEGF", ")", "antibodies", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [23, 24]}}
{"token": ["Recently", ",", "some", "investigators", "have", "explored", "the", "potential", "usefulness", "of", "C1511755#ent", "<e1>", "as", "an", "C1413240#ent", "<e2>", ",", "antiinflammatory", ",", "and", "immunosuppressive", "agent"], "h": {"id": "C1511755", "name": "C1511755#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [14, 15]}}
{"token": ["In", "a", "comparison", "made", "with", "both", "a", "C0025376#ent", "<e1>", "and", "a", "control", "group", "C0700583#ent", "<e2>", "was", "shown", "to", "be", "an", "effective", "analgesic", "."], "h": {"id": "C0025376", "name": "C0025376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [13, 14]}}
{"token": ["A", "34-year-old", "white", "man", "C0085113#ent", "<e1>", "found", "to", "have", "severe", "C0020545#ent", "<e2>", "to", "a", "coarctation", "of", "the", "abdominal", "aorta", "bilateral", "renal", "artery", "stenosis", "saccular", "aneurysms"], "h": {"id": "C0085113", "name": "C0085113#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020545", "name": "C0020545#ent", "pos": [10, 11]}}
{"token": ["Patients", "with", "C0085113#ent", "<e1>", "must", "be", "screened", "for", "pheochromoctyoma", "and", "C0020545#ent", "<e2>"], "h": {"id": "C0085113", "name": "C0085113#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020545", "name": "C0020545#ent", "pos": [10, 11]}}
{"token": ["It", "was", "noticed", "that", "coxsackievirus", "A16", "C1705860#ent", "<e1>", ")", "and", "enterovirus", "71", "EV71", ")", "were", "two", "major", "C2064919#ent", "<e2>", "hand", ",", "foot", "and", "mouth", "disease", "HFMD", ")", "in", "children", "."], "h": {"id": "C1705860", "name": "C1705860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2064919", "name": "C2064919#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "long-term", "pretreatment", "with", "C0085196#ent", "<e1>", "and", "hence", "efficient", "C0039051#ent", "<e2>", "did", "neither", "affect", "the", "course", "of", "arthritis", "nor", "the", "outcome", "of", "T", "cell-dependent", "and", "independent", "inflammatory", "reactions"], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039051", "name": "C0039051#ent", "pos": [11, 12]}}
{"token": ["Crystallins", "are", "a", "diverse", "group", "of", "C0086376#ent", "<e1>", "that", "contribute", "to", "the", "transparency", "and", "C0034951#ent", "<e2>", "properties", "of", "the", "eye", "lens"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034951", "name": "C0034951#ent", "pos": [14, 15]}}
{"token": ["Obesity", "is", "more", "linked", "to", "C0042373#ent", "<e1>", "including", "atherosclerosis", "and", "C4049883#ent", "<e2>", "change", ",", "after", "balloon", "angioplasty"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4049883", "name": "C4049883#ent", "pos": [10, 11]}}
{"token": ["The", "hallmarks", "of", "rheumatic", "fever", "arthritis", ",", "C0031046#ent", "<e1>", ",", "cutaneous", "disease", "chorea", ",", "and", "subsequent", "acquired", "C3258293#ent", "<e2>"], "h": {"id": "C0031046", "name": "C0031046#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3258293", "name": "C3258293#ent", "pos": [17, 18]}}
{"token": ["Tiotropium", "(", "C0905678#ent", "<e1>", ";", "Ba679BR", ")", "is", "a", "new-generation", ",", "long-acting", "C0354764#ent", "<e2>", "has", "muscarinic", "M(1", ")", "and", "M(3", ")", "receptor", "subtype", "selectivity", "."], "h": {"id": "C0905678", "name": "C0905678#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0354764", "name": "C0354764#ent", "pos": [12, 13]}}
{"token": ["An", "asymptomatic", "36-year-old", "woman", "had", "high", "cholesterol", "levels", "to", "heterozygous", "familial", "hypercholesterolemia", "C1706242#ent", "<e1>", ")", "and", "a", "family", "history", "coronary", "artery", "disease", "C0010068#ent", "<e2>", ")", "but", "no", "other", "risk", "factors"], "h": {"id": "C1706242", "name": "C1706242#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [22, 23]}}
{"token": ["C1706236#ent", "<e1>", "from", "M.", "bovis", "BCG", "contains", "a", "short", "C0053413#ent", "<e2>", "backbone", ",", "highly", "branched", "arabinofuranosyl-containing", "side", "chains", "and", "several", "mannosyl", "residues", "capping", "the", "non-reducing", "termini", "of", "these", "side", "chains"], "h": {"id": "C1706236", "name": "C1706236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0053413", "name": "C0053413#ent", "pos": [9, 10]}}
{"token": ["C1425705#ent", "<e1>", "containing", "an", "C3715179#ent", "<e2>", "with", "a", "length", "of", "900", "bp", ",", "encoding", "a", "protein", "with", "a", "signal", "peptide", "sequence", "an", "adh_short", "domain", "."], "h": {"id": "C1425705", "name": "C1425705#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3715179", "name": "C3715179#ent", "pos": [4, 5]}}
{"token": ["On", "the", "other", "hand", ",", "oral", "administration", "C0011800#ent", "<e1>", "an", "analogous", "alpha-1,6", "C0017696#ent", "<e2>", ",", "did", "not", "show", "any", "augmentation", "effects", "on", "IL-2", "production", "."], "h": {"id": "C0011800", "name": "C0011800#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017696", "name": "C0017696#ent", "pos": [12, 13]}}
{"token": ["Extracts", "from", "the", "both", "plants", "inhibited", "xanthine", "oxidase", "C0023837#ent", "<e1>", "activites", ",", "and", "were", "scavengers", "of", "the", "ABTS*+", "free", "radical", "C0147003#ent", "<e2>", "Equivalent", "Antioxidant", "Capacity", "assay", "(", "TEAC", ")", "."], "h": {"id": "C0023837", "name": "C0023837#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0147003", "name": "C0147003#ent", "pos": [20, 21]}}
{"token": ["C0036723#ent", "<e1>", "serine", "aminotransferase", "activities", "were", "absent", ",", "whereas", "3-phosphoglycerate", "dehydrogenase", "C1420038#ent", "<e2>", "activities", "were", "markedly", "increased", "in", "both", "tumour", "types"], "h": {"id": "C0036723", "name": "C0036723#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420038", "name": "C1420038#ent", "pos": [11, 12]}}
{"token": ["Phylogenetic", "analyses", "one", "of", "them", "clearly", "with", "the", "C0055673#ent", "<e1>", ",", "whereas", "the", "other", "C0079429#ent", "<e2>", "is", "equally", "related", "to", "cathepsin", "G", "the", "granzymes", "."], "h": {"id": "C0055673", "name": "C0055673#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}}
{"token": ["Retroviral", "transduction", "myeloid", "progenitors", "that", "C1864339#ent", "<e1>", "is", "the", "fourth", "known", "fusion", "of", "C0919528#ent", "<e2>", "with", "a", "cytoplasmic", "protein", "has", "no", "in", "vitro", "transformation", "capability", ",", "thus", "establishing", "a", "potential", "subgroup", "among", "the", "C0919528#ent", "<e2>", "fusion", "proteins"], "h": {"id": "C1864339", "name": "C1864339#ent", "pos": [5, 6]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0919528", "name": "C0919528#ent", "pos": [13, 14]}}
{"token": ["Femoral", "calcium", "and", "strength", "were", "decreased", "by", "OVX", "in", "the", "rats", "C0342895#ent", "<e1>", "on", "the", "control", "and", "C4082489#ent", "<e2>", "diets", ",", "but", "not", "in", "the", "rats", "C0342895#ent", "<e1>", "on", "the", "P-GGH", "diet", "."], "h": {"id": "C4082489", "name": "C4082489#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [11, 12]}}
{"token": ["Efficient", "transcription", "of", "the", "human", "T-cell", "leukemia", "virus", "type", "1", "HTLV-1", ")", "genome", "requires", "Tax", ",", "a", "virally", "encoded", "C0812315#ent", "<e1>", "in", "complex", "with", "the", "cellular", "transcription", "factor", "CREB", "and", "the", "coactivators", "C3887789#ent", "<e2>", "."], "h": {"id": "C0812315", "name": "C0812315#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3887789", "name": "C3887789#ent", "pos": [32, 33]}}
{"token": ["This", "mitogenic", "effect", "mediated", "via", "C0119860#ent", "<e1>", "GAGs", ")", ",", "FGFR1", ",", "and", "the", "C4082284#ent", "<e2>", "ERK", ")", "pathway", "."], "h": {"id": "C0119860", "name": "C0119860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [14, 15]}}
{"token": ["C2984537#ent", "<e1>", "such", "as", "the", "C3540783#ent", "<e2>", ",", "can", "correct", "dyslipidemia", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540783", "name": "C3540783#ent", "pos": [5, 6]}}
{"token": ["C2984537#ent", "<e1>", "is", "the", "molecular", "target", "the", "hypolipidemic", "C3540783#ent", "<e2>", "including", "benzafibrate", "and", "clofibrate", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540783", "name": "C3540783#ent", "pos": [8, 9]}}
{"token": ["We", "have", "evaluated", "an", "assay", "in", "which", "transcription-mediated", "amplification", "TMA", ")", "of", "BCR-ABL", "and", "C1412097#ent", "<e1>", "transcripts", "is", "achieved", "using", "C1955880#ent", "<e2>", "RNA", "polymerase"], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "polymorphisms", "of", "C1417679#ent", "<e1>", "encoding", "endogenous", "free-radical", "scavenging", "systems", "such", "as", "paraoxonase", "1", "C1334902#ent", "<e2>", ")", ",", "and", "anti-glycation", "defences", ",", "such", "as", "glyoxalase", "I", "GI", ")", ",", "could", "influence", "susceptibility", "to", "MS", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334902", "name": "C1334902#ent", "pos": [15, 16]}}
{"token": ["Sequencing", "of", "exons", "16", "and", "17", "of", "the", "C0085151#ent", "<e1>", "the", "exons", "which", "encode", "the", "beta-amyloid", "fragment", "in", "pedigree", "C2986919#ent", "<e2>", "revealed", "them", "to", "be", "of", "normal", "sequence"], "h": {"id": "C0085151", "name": "C0085151#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2986919", "name": "C2986919#ent", "pos": [19, 20]}}
{"token": ["The", "C1413858#ent", "<e1>", "the", "HSD17B1", "A", "allele", "considered", "\"", "high-risk", "\"", "C0002085#ent", "<e2>", "."], "h": {"id": "C1413858", "name": "C1413858#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [11, 12]}}
{"token": ["Similar", "values", "were", "obtained", "in", "pregnant", "women", "euthyroid", "patients", "with", "C0677607#ent", "<e1>", "and", "a", "patient", "with", "C0087090#ent", "<e2>"], "h": {"id": "C0677607", "name": "C0677607#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0087090", "name": "C0087090#ent", "pos": [16, 17]}}
{"token": ["Secondary", "structural", "predictions", "structural", "modelling", "the", "MUP", "1", "crystal", "structure", "gave", "convincing", "evidence", "that", "the", "three-dimensional", "structure", "C4049865#ent", "<e1>", "closely", "resembles", "that", "of", "the", "C0078147#ent", "<e2>", "."], "h": {"id": "C4049865", "name": "C4049865#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0078147", "name": "C0078147#ent", "pos": [24, 25]}}
{"token": ["Because", "of", "overlapping", "features", ",", "C1839130#ent", "<e1>", "patients", "are", "commonly", "misdiagnosed", "as", "C0013423#ent", "<e2>", "essential", "tremor", "Parkinson's", "disease", "or", "Parkinson's-plus", "syndromes"], "h": {"id": "C1839130", "name": "C1839130#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0013423", "name": "C0013423#ent", "pos": [12, 13]}}
{"token": ["C0040213#ent", "<e1>", "of", "the", "auricles", "(", "9/10", "patients", ")", "and", "C0003892#ent", "<e2>", "(", "8/10", "patients", ")", "are", "the", "most", "common", "presenting", "signs", "."], "h": {"id": "C0040213", "name": "C0040213#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003892", "name": "C0003892#ent", "pos": [10, 11]}}
{"token": ["They", "have", "found", "C0398650#ent", "<e1>", "two", "cases", ",", "agranulocytosis", "in", "two", "cases", "and", "C0002880#ent", "<e2>", "one", "case", "."], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002880", "name": "C0002880#ent", "pos": [13, 14]}}
{"token": ["Diazepam", "interferes", ",", "but", "procainamide", ",", "chlordiazepoxide", ",", "C0034414#ent", "<e1>", ",", "lidocaine", ",", "propranolol", ",", "C1161332#ent", "<e2>", ",", "and", "many", "other", "basic", "drugs", "do", "not", "."], "h": {"id": "C0034414", "name": "C0034414#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1161332", "name": "C1161332#ent", "pos": [15, 16]}}
{"token": ["The", "cylindrical", "C1424667#ent", "<e1>", "chaperone", "ClpA", "mediates", "C0059946#ent", "<e2>", "unfolding", "of", "substrate", "proteins", "\"", "tag", "\"", "sequences", ",", "such", "as", "the", "11-residue", "ssrA", "sequence", "appended", "to", "proteins", "translationally", "stalled", "at", "ribosomes", "."], "h": {"id": "C1424667", "name": "C1424667#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [7, 8]}}
{"token": ["We", "summarized", "the", "current", "therapeutic", "options", "for", "pulmonary", "arterial", "hypertension", "conventional", "treatments", "calcium", "channel", "blockers", "anticoagulation", ",", "digitalis", ",", "C0596110#ent", "<e1>", ",", "and", "new", "treatment", ":", "prostacyclin", ",", "bosentan", ",", "C0529793#ent", "<e2>", ",", "ambrisentan", "."], "h": {"id": "C0596110", "name": "C0596110#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0529793", "name": "C0529793#ent", "pos": [30, 31]}}
{"token": ["The", "rank", "order", "of", "pA(2", ")", "values", "was", "C1956296#ent", "<e1>", ">", "or", "=", "atropine", ">", "oxybutynin", ">", "C0138666#ent", "<e2>", "."], "h": {"id": "C1956296", "name": "C1956296#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0138666", "name": "C0138666#ent", "pos": [17, 18]}}
{"token": ["Interaction", "between", "C1823597#ent", "<e1>", "and", "ERalpha", "was", "supported", "by", "mammalian", "two-hybrid", ",", "C1428159#ent", "<e2>", "pull-down", ",", "and", "co-immunoprecipitation", "analyses"], "h": {"id": "C1823597", "name": "C1823597#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1428159", "name": "C1428159#ent", "pos": [12, 13]}}
{"token": ["The", "interaction", "of", "C1823597#ent", "<e1>", "with", "UBC9", "was", "confirmed", "by", "co-immunoprecipitation", "and", "C1428159#ent", "<e2>", "pull-down", "analyses", "."], "h": {"id": "C1823597", "name": "C1823597#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428159", "name": "C1428159#ent", "pos": [12, 13]}}
{"token": ["cDNA", "cloning", "glutamate", "transporter", "C1420120#ent", "<e1>", "from", "mouse", "brain", "and", "C0023899#ent", "<e2>", "has", "revealed", "that", "5'-ends", "of", "the", "messages", "are", "different", "between", "brain", "and", "C0023899#ent", "<e2>", "."], "h": {"id": "C1420120", "name": "C1420120#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}}
{"token": ["C1619692#ent", "<e1>", "NSF", ")", "is", "a", "C0016034#ent", "<e2>", "in", "renal", "failure", "patients", "that", "may", "lead", "to", "severe", "physical", "disability"], "h": {"id": "C1619692", "name": "C1619692#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016034", "name": "C0016034#ent", "pos": [6, 7]}}
{"token": ["N", ",", "N'-Dicyclohexylcarbodiimide", "and", "4-chloro-7-nitrobenzofuran", ",", "inhibitors", "of", "the", "C0018437#ent", "<e1>", "dissipated", "the", "proton", "concentration", "gradient", "when", "C0007044#ent", "<e2>", "was", "present", "."], "h": {"id": "C0018437", "name": "C0018437#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007044", "name": "C0007044#ent", "pos": [17, 18]}}
{"token": ["C0031602#ent", "<e1>", "a", "key", "C0027203#ent", "<e2>", "for", "the", "synthesis", "of", "releasable", "glutamate", ",", "is", "inhibited", "by", "the", "diazoketone", "6-diazo-5-oxo-L-norleucine", "DON", ")", ",", "which", "greatly", "reduces", "glutamate", "release", "."], "h": {"id": "C0031602", "name": "C0031602#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "association", "between", "C1540147#ent", "<e1>", "a", "member", "of", "the", "C4288081#ent", "<e2>", "and", "lung", "cancer", "which", "has", "never", "been", "reported", "to", "date", "."], "h": {"id": "C1540147", "name": "C1540147#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4288081", "name": "C4288081#ent", "pos": [17, 18]}}
{"token": ["Additionally", ",", "long-term", "regulation", "by", "glucose", "and", "the", "C0362046#ent", "<e1>", "e.g.", ",", "fatty", "acids", "ketones", ")", "on", "C0031686#ent", "<e2>", "pyruvate", "dehydrogenase", "and", "carnitine", "palmitoyltransferase", "1", "to", "be", "explored", "in", "greater", "depth", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [17, 18]}}
{"token": ["She", "denied", "C1457887#ent", "<e1>", "did", "not", "have", "a", "history", "of", "smoking", "or", "industrial", "exposure", "C0085169#ent", "<e2>", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085169", "name": "C0085169#ent", "pos": [14, 15]}}
{"token": ["This", "C0231852#ent", "<e1>", "pericardial", "decompression", "similar", "to", "that", "seen", "occasionally", "with", "pericardiectomy", "in", "C0031048#ent", "<e2>", "may", "be", "more", "frequent", "than", "currently", "appreciated", "."], "h": {"id": "C0231852", "name": "C0231852#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031048", "name": "C0031048#ent", "pos": [13, 14]}}
{"token": ["These", "data", "indicate", "that", "the", "polyamines", ",", "C0031957#ent", "<e1>", "and", "spermidine", "attenuate", "responses", "mediated", "through", "the", "N-methyl-D-aspartate", "(", "C0022614#ent", "<e2>", ")", ",", "NMDA-associated", "glycine", "receptor", "and", "quisqualate", "receptors"], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [18, 19]}}
{"token": ["The", "analysis", "of", "C3889400#ent", "<e1>", "and", "psi", "zeta", "gene", "constructs", "stably", "integrated", "into", "a", "C1415489#ent", "<e2>", "cell", "line", "K562", "that", "exogenous", "C3889400#ent", "<e1>", "but", "not", "psi", "zeta", "genes", "are", "transcriptionally", "active", "."], "h": {"id": "C1415489", "name": "C1415489#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3889400", "name": "C3889400#ent", "pos": [3, 4]}}
{"token": ["C0002726#ent", "<e1>", "with", "distinct", "molecular", "masses", "found", "in", "the", "starch", "of", "C1572795#ent", "<e2>", "embryos", "compared", "with", "the", "starch", "of", "pea", "leaves"], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1572795", "name": "C1572795#ent", "pos": [11, 12]}}
{"token": ["Endocannabinoids", "are", "a", "new", "class", "of", "C0127400#ent", "<e1>", "which", "include", "amides", ",", "esters", "and", "C0014996#ent", "<e2>", "of", "long-chain", "polyunsaturated", "fatty", "acids"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014996", "name": "C0014996#ent", "pos": [14, 15]}}
{"token": ["a", "kinase(s", ")", "which", "activates", "microtubule-associated", "protein", "2", "C0919496#ent", "<e1>", ")", "kinase", ",", "a", "kinase", "that", "phosphorylates", "the", "C1420583#ent", "<e2>", "and", "a", "possibly", "novel", "serine/threonine", "protein", "kinase"], "h": {"id": "C0919496", "name": "C0919496#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420583", "name": "C1420583#ent", "pos": [18, 19]}}
{"token": ["C0289313#ent", "<e1>", "PKC", "phosphorylates", "Thr35", "in", "C0031640#ent", "<e2>", "gamma", "."], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [6, 7]}}
{"token": ["To", "examine", "the", "role", "of", "TR", "beta", "bone", ",", "we", "have", "reviewed", "the", "growth", "abnormalities", "the", "C1306792#ent", "<e1>", "RTH", "caused", "by", "mutations", "in", "the", "C0242988#ent", "<e2>"], "h": {"id": "C1306792", "name": "C1306792#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0242988", "name": "C0242988#ent", "pos": [24, 25]}}
{"token": ["Neither", "the", "growth", "of", "Salmonella", "typhimurium", "glycerol", "or", "citrate", "media", "the", "level", "of", "C0001109#ent", "<e1>", "the", "strain", "is", "affected", "by", "the", "loss", "of", "C0673071#ent", "<e2>"], "h": {"id": "C0001109", "name": "C0001109#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0673071", "name": "C0673071#ent", "pos": [23, 24]}}
{"token": ["We", "also", "noted", "C1366557#ent", "<e1>", "polyps", "of", "individuals", "with", "C0694883#ent", "<e2>", ",", "suggesting", "that", "the", "identified", "stromal-derived", "mechanism", "of", "tumor", "suppression", "also", "relevant", "in", "C0694883#ent", "<e2>", "."], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0694883", "name": "C0694883#ent", "pos": [9, 10]}}
{"token": ["MGA", "type", "III", "Costeff", "optic", "atrophy", "syndrome", "autosomal", "recessive", "atrophy-3", "or", "C0574084#ent", "<e1>", "OMIM", "258501", ")", "is", "distinguished", "by", "early", "C0029124#ent", "<e2>", "later-onset", "spasticity", ",", "extrapyramidal", "dysfunction", "ataxia", ",", "and", "occasional", "cognitive", "deficits"], "h": {"id": "C0574084", "name": "C0574084#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0029124", "name": "C0029124#ent", "pos": [20, 21]}}
{"token": ["C1704311#ent", "<e1>", "been", "shown", "to", "be", "beneficial", "in", "the", "setting", "of", "C0948089#ent", "<e2>", "and", "as", "an", "adjunct", "to", "thrombolysis", "for", "acute", "myocardial", "infarction", "AMI", ")", "."], "h": {"id": "C1704311", "name": "C1704311#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0948089", "name": "C0948089#ent", "pos": [11, 12]}}
{"token": ["C0023895#ent", "<e1>", "diagnosed", "in", "eight", "animals", "and", "in", "these", "C0022346#ent", "<e2>", "and", "increased", "conjugated", "bilirubin", "and", "alkaline", "phosphatase", "a", "feature", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0022346", "name": "C0022346#ent", "pos": [9, 10]}}
{"token": ["The", "C1413231#ent", "<e1>", "was", "to", "find", "out", "the", "effects", "of", "endothelin-1", "(", "C3273437#ent", "<e2>", ")", "in", "salmon", "(", "Salmo", "salar", "cardiac", "contractile", "endocrine", "function", "its", "possible", "interaction", "with", "beta-adrenergic", "regulation"], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [12, 13]}}
{"token": ["The", "functional", "importance", "of", "PKC", "alpha", "C1414371#ent", "<e1>", "shuttling", "is", "highlighted", "by", "the", "high", "cytosolic", "C1414371#ent", "<e1>", "content", "detected", "in", "C0220742#ent", "<e1>", "stably", "overexpressing", "PKC", "alpha", "compared", "with", "mock-transfected", "cells", "."], "h": {"id": "C1414371", "name": "C1414371#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0220742", "name": "C0220742#ent", "pos": [20, 21]}}
{"token": ["With", "age-specific", "diminished", "and", "excluded", "ovarian", "function", "C0853662#ent", "<e1>", "60", "%", "of", "females", "may", "develop", "various", "C0012634#ent", "<e2>", "the", "menopausal", "syndrome", "urogenital", "and", "cardiovascular", "diseases", "osteoporosis", ")", "."], "h": {"id": "C0853662", "name": "C0853662#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [16, 17]}}
{"token": ["In", "Salmonella", "typhimurium", "peptidase", "N", "C0135894#ent", "<e1>", "equally", "active", "in", "C0054741#ent", "<e2>", "and", "activating", "albomycin", "."], "h": {"id": "C0135894", "name": "C0135894#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [10, 11]}}
{"token": ["The", "distribution", "of", "C3539694#ent", "<e1>", "and", "PP1C", "as", "well", "as", "C0027103#ent", "<e2>", "examined", "in", "smooth", "muscle", "cells", "fibroblasts", "by", "immunofluorescence", "microscopy", "immunoblotting", "after", "differential", "extraction"], "h": {"id": "C3539694", "name": "C3539694#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027103", "name": "C0027103#ent", "pos": [10, 11]}}
{"token": ["In", "patients", "with", "localized", "C0037580#ent", "<e1>", "US", "is", "able", "to", "assess", "the", "presence", "of", "a", "C0742078#ent", "<e2>", "lesion", "and", "to", "characterize", "its", "nature", "in", "many", "cases", "."], "h": {"id": "C0037580", "name": "C0037580#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0742078", "name": "C0742078#ent", "pos": [15, 16]}}
{"token": ["In", "this", "paper", ",", "the", "chromatographic", "properties", "of", "eleven", "O-TMS-quinoxalinols", "on", "C1419089#ent", "<e1>", ",", "OV-17", "and", "Dexsil", "300", "reported", "in", "terms", "of", "C0054666#ent", "<e2>"], "h": {"id": "C1419089", "name": "C1419089#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0054666", "name": "C0054666#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "the", "action", "of", "quisqualate", "is", "virtually", "unaffected", "by", "C1333909#ent", "<e1>", "+", "and", "is", "resistant", "to", "C0754188#ent", "<e2>", "inhibition", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0754188", "name": "C0754188#ent", "pos": [18, 19]}}
{"token": ["We", "have", "now", "analyzed", "nonhairpin", "coding", "ends", "associated", "with", "C0017350#ent", "<e1>", "cells", "undergoing", "C1258073#ent", "<e2>"], "h": {"id": "C0017350", "name": "C0017350#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1258073", "name": "C1258073#ent", "pos": [13, 14]}}
{"token": ["To", "determine", ",", "using", "antisense", "technology", "whether", "the", "C0079068#ent", "<e1>", "protooncogene", "is", "involved", "in", "cell", "proliferation", "C3536869#ent", "<e2>", "(", "GAG", ")", "synthesis", "in", "cultured", "orbital", "fibroblasts", "OF", ")", "."], "h": {"id": "C0079068", "name": "C0079068#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536869", "name": "C3536869#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "show", "that", "C2348049#ent", "<e1>", "is", "itself", "associated", "with", "C1333891#ent", "<e2>", "in", "vivo"], "h": {"id": "C2348049", "name": "C2348049#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [10, 11]}}
{"token": ["C0010592#ent", "<e1>", "A", "administration", "or", "C1744558#ent", "<e2>", "athymic", "nude", "rats", "decreases", "the", "smooth", "muscle", "hyperplasia", "in", "venous", "grafts", "exposed", "to", "arterial", "pressure"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1744558", "name": "C1744558#ent", "pos": [5, 6]}}
{"token": ["So", "in", "the", "treatment", "of", "coexisting", "C0006849#ent", "<e1>", "and", "inflammatory", "dermatoses", "combination", "of", "C0009074#ent", "<e2>", "1", "%", "+", "beclomethasone", "0.025", "%", "(", "candid-B", "cream", ")", "was", "found", "to", "be", "highly", "effective", "."], "h": {"id": "C0006849", "name": "C0006849#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0009074", "name": "C0009074#ent", "pos": [13, 14]}}
{"token": ["Niemann-Pick", "Disease", "NPD", ")", "is", "an", "autosomal", "C0017361#ent", "<e1>", "lysosomal", "storage", "disorder", "by", "a", "deficiency", "of", "C1420259#ent", "<e2>", "ASM", ")", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420259", "name": "C1420259#ent", "pos": [16, 17]}}
{"token": ["Interferon-gamma", "(", "IFN-gamma", ")", "and", "interleukin", "4", "C1334119#ent", "<e1>", ")", "production", "was", "assessed", "in", "the", "popliteal", "lymph", "node", "C1418650#ent", "<e2>", ")", "at", "Day", "2", "and", "Day", "5", "after", "injection", "by", "flow", "cytometry", "ELISA", "."], "h": {"id": "C1334119", "name": "C1334119#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418650", "name": "C1418650#ent", "pos": [18, 19]}}
{"token": ["The", "membrane-integrated", "part", "of", "the", "wild-type", "C0023689#ent", "<e1>", "highly", "sensitive", "to", "C0101555#ent", "<e2>", "membrane", "energization", "and", "restoration", "of", "lactate-dependent", "energization", "of", "ATPase-depleted", "membranes", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [11, 12]}}
{"token": ["PPC", "C0023689#ent", "<e1>", "fall", "into", "two", "classes", ":", "eukaryotic", ",", "C0101555#ent", "<e2>", "and", "eubacterial", ",", "CTP-dependent", "enzymes", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [10, 11]}}
{"token": ["The", "optimized", "matrix", "preparation", "was", "successfully", "applied", "to", "identify", "larger", "C0086376#ent", "<e1>", "by", "large", "C0375381#ent", "<e2>", "tag", "researches", "in", "protein", "databases", "BLASTp", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0375381", "name": "C0375381#ent", "pos": [14, 15]}}
{"token": ["C2931689#ent", "<e1>", "DM1", ")", "is", "an", "C0410190#ent", "<e2>", "by", "expansion", "of", "cytosine-thymine-guanine", "(", "CTG", ")", "trinucleotide", "repeats", "the", "myotonic", "dystrophy", "protein", "kinase", "DMPK", ")", "gene", "."], "h": {"id": "C2931689", "name": "C2931689#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0410190", "name": "C0410190#ent", "pos": [6, 7]}}
{"token": ["The", "influence", "of", "six", "C0012177#ent", "<e1>", "egg", "albumin", "casein", ",", "gelatin", ",", "soy", "protein", "pea", "protein", "and", "C2827346#ent", "<e2>", "on", "satiety", "and", "food", "intake", "investigated", "."], "h": {"id": "C0012177", "name": "C0012177#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C2827346", "name": "C2827346#ent", "pos": [17, 18]}}
{"token": ["Using", "this", "strategy", ",", "benzofuran", "derivatives", "to", "the", "C0027410#ent", "<e1>", "naloxone", ",", "and", "to", "the", "mu-opioid", "receptor", "agonists", ",", "C0282275#ent", "<e2>", "and", "oxycodone", ",", "were", "synthesized", "."], "h": {"id": "C0027410", "name": "C0027410#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282275", "name": "C0282275#ent", "pos": [19, 20]}}
{"token": ["The", "resulting", "C0879262#ent", "<e1>", "mutants", "show", "C0068803#ent", "<e2>", "and", "have", "lost", "their", "ability", "to", "utilize", "NADPH", "as", "a", "coenzyme", ",", "but", "retain", "those", "catalytic", "activities"], "h": {"id": "C0879262", "name": "C0879262#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0068803", "name": "C0068803#ent", "pos": [6, 7]}}
{"token": ["Two", "cases", "of", "benign", "C0151740#ent", "<e1>", "pseudotumor", "cerebri", "associated", "with", "non", "specific", "C0221423#ent", "<e2>", "in", "infants", "are", "reported", "."], "h": {"id": "C0151740", "name": "C0151740#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [12, 13]}}
{"token": ["Oxygen", "radical", "metabolism", "been", "hypothesized", "to", "be", "important", "for", "cancer", ",", "C0026850#ent", "<e1>", "and", "other", "disorders", ",", "so", "C1418880#ent", "<e2>", "should", "be", "considered", "a", "candidate", "gene", "for", "these", "diseases", "."], "h": {"id": "C0026850", "name": "C0026850#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418880", "name": "C1418880#ent", "pos": [18, 19]}}
{"token": ["This", "interaction", "of", "Rsr1p", "with", "the", "effector", "of", "C0034678#ent", "<e1>", "in", "S.", "cerevisiae", "that", "C1335590#ent", "<e2>", "may", "revert", "ras-induced", "transformation", "of", "mammalian", "cells", "affecting", "the", "interaction", "of", "ras", "p21", "with", "its", "effector", "."], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335590", "name": "C1335590#ent", "pos": [14, 15]}}
{"token": ["The", "response", "to", "various", "methods", "of", "treatment", "may", "vary", ",", "depending", "on", "the", "severity", "of", "C0264490#ent", "<e1>", "the", "cause", "of", "the", "C1145670#ent", "<e2>"], "h": {"id": "C0264490", "name": "C0264490#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [21, 22]}}
{"token": ["We", "show", "that", "yeast", "HAC1", "mRNA", "is", "correctly", "spliced", "in", "mammalian", "cells", "UPR", "induction", "and", "that", "mammalian", "C3812220#ent", "<e1>", "can", "precisely", "cleave", "both", "C4021730#ent", "<e2>"], "h": {"id": "C3812220", "name": "C3812220#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4021730", "name": "C4021730#ent", "pos": [23, 24]}}
{"token": ["Thousand", "and", "one", "C2917660#ent", "<e1>", "TAO", ")", "kinases", "are", "C0169101#ent", "<e2>", "MAP3Ks", ")", "that", "activate", "p38", "MAPK"], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [9, 10]}}
{"token": ["The", "neutralizing", "antibody", "C1704816#ent", "<e1>", "had", "no", "effect", "the", "two-fold", "increase", "in", "C0812281#ent", "<e2>", "generation", "induced", "by", "phenylephrine", "(", "DCF", "fluorescence", ")", ",", "suggesting", "that", "stimulation", "of", "NAD(P)H", "oxidase", "alpha1-adrenoceptor", "occupation", "precedes", "C1704816#ent", "<e1>", "release", "."], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [12, 13]}}
{"token": ["The", "highest", "level", "of", "identity", "to", "other", "C0008429#ent", "<e1>", "was", "with", "C1869509#ent", "<e2>", "of", "Caenorhabditis", "elegans"], "h": {"id": "C0008429", "name": "C0008429#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1869509", "name": "C1869509#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "describe", "two", "German", "siblings", "with", "clinical", "characteristics", "those", "seen", "in", "many", "cases", "of", "C0024814#ent", "<e1>", "except", "that", "a", "marked", "C0740279#ent", "<e2>", "not", "detectable", "in", "our", "patients", "."], "h": {"id": "C0024814", "name": "C0024814#ent", "pos": [16, 17]}, "relation": "has_manifestation", "t": {"id": "C0740279", "name": "C0740279#ent", "pos": [22, 23]}}
{"token": ["We", "sought", "to", "better", "characterize", "the", "effects", "of", "C0019693#ent", "<e1>", "Nef", "on", "T", "cell", "function", "examining", "chemotaxis", "in", "response", "to", "stromal", "cell-derived", "factor-1alpha", "C1332817#ent", "<e2>", ")", "as", "well", "as", "CXCR4", "signaling", "molecules"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332817", "name": "C1332817#ent", "pos": [23, 24]}}
{"token": ["C0019202#ent", "<e1>", "Wilson's", "disease", "is", "a", "hereditary", "disease", "which", "C0025517#ent", "<e2>", "copper", "leads", "to", "its", "accumulation", "in", "the", "liver", ",", "brain", ",", "cornea", "and", "kidneys", "with", "consequent", "pathologic", "changes", "those", "organs", "."], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}}
{"token": ["Samples", "are", "treated", "with", "the", "C0073186#ent", "<e1>", "or", "the", "C1705068#ent", "<e2>", "form", "of", "acetic", "anhydride", "peptides", "that", "contain", "C-terminal", "basic", "amino", "acids", "isolated", "by", "affinity", "chromatography", "anhydrotrypsin", "agarose", ",", "and", "the", "isolated", "peptides", "are", "analyzed", "by", "mass", "spectrometry"], "h": {"id": "C0073186", "name": "C0073186#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705068", "name": "C1705068#ent", "pos": [9, 10]}}
{"token": ["Therefore", ",", "C0002395#ent", "<e1>", "patients", "were", "compared", "to", "healthy", "controls", "respect", "to", "their", "C0026961#ent", "<e2>", "diameters", "and", "responses", "to", "an", "acetylcholine", "antagonist"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026961", "name": "C0026961#ent", "pos": [13, 14]}}
{"token": ["He", "presented", "with", "an", "abdominal", "mass", "associated", "with", "severe", "inflammatory", "response", "by", "fever", ",", "impaired", "growth", "C3277671#ent", "<e1>", ",", "and", "microcytic", ",", "C0002884#ent", "<e2>"], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002884", "name": "C0002884#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "have", "further", "investigated", "the", "link", "between", "insulin", "resistance", "PKC", "by", "assessing", "the", "effects", "of", "C1257987#ent", "<e1>", "insulin-sensitizer", "BRL-49653", "on", "PKC", "C0022173#ent", "<e2>", "in", "muscle", "."], "h": {"id": "C1257987", "name": "C1257987#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [22, 23]}}
{"token": ["Effects", "on", "neuronal", "rounding", "and", "apoptosis", "were", "also", "detected", ",", "suggesting", "therapeutic", "utility", "may", "result", "from", "interference", "with", "downstream", "components", "of", "thrombin", "signaling", "pathways", "human", "C0221163#ent", "<e1>", "and", "possibly", "other", "C0751870#ent", "<e2>"], "h": {"id": "C0221163", "name": "C0221163#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [30, 31]}}
{"token": ["By", "using", "previously", "described", "canine", "cDNA", "encoding", "C0020818#ent", "<e1>", "as", "a", "probe", ",", "the", "canine", "C1442485#ent", "<e2>", "been", "cloned", "and", "characterized", "."], "h": {"id": "C0020818", "name": "C0020818#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1442485", "name": "C1442485#ent", "pos": [15, 16]}}
{"token": ["C0033551#ent", "<e1>", "inhibition", "did", "not", "block", "the", "effect", "of", "C3539567#ent", "<e2>", "on", "VCAM-1", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539567", "name": "C3539567#ent", "pos": [9, 10]}}
{"token": ["Compared", "to", "adult", ",", "gene", "expression", "in", "aged", "hearts", "translated", "into", "a", "reduced", "C3658275#ent", "<e1>", ",", "with", "decreased", "NADH-dehydrogenase", "and", "C0018437#ent", "<e2>", ")", "ATPase", "complex", "activities", "and", "capacity", "for", "oxygen-utilization", "and", "ATP", "synthesis", "."], "h": {"id": "C3658275", "name": "C3658275#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018437", "name": "C0018437#ent", "pos": [20, 21]}}
{"token": ["The", "resting", "membrane", "potential", "C1421895#ent", "<e1>", ")", "of", "skeletal", "muscle", "cells", "investigated", "in", "a", "hyperdynamic", "animal", "model", "C0036690#ent", "<e2>", "."], "h": {"id": "C1421895", "name": "C1421895#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [17, 18]}}
{"token": ["The", "amount", "of", "C0027203#ent", "<e1>", "bound", "to", "C1708801#ent", "<e2>", "is", "inversely", "proportional", "and", "the", "amount", "of", "C0027203#ent", "<e1>", "bound", "to", "Ab2", "is", "directly", "proportional", "to", "the", "analyte", "concentration", "."], "h": {"id": "C1708801", "name": "C1708801#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [3, 4]}}
{"token": ["Phosphatase", "in", "activated", "T", "cells", "C1414184#ent", "<e1>", ")", "is", "a", "C3889283#ent", "<e2>", "early", "responsive", "gene", "."], "h": {"id": "C1414184", "name": "C1414184#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889283", "name": "C3889283#ent", "pos": [10, 11]}}
{"token": ["Both", ",", "exogenously", "added", "as", "well", "as", "endogenously", ",", "by", "C0037533#ent", "<e1>", "cGMP", "were", "found", "to", "enhance", "C1710304#ent", "<e2>", "gene", "expression", "and", "production", "."], "h": {"id": "C0037533", "name": "C0037533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [17, 18]}}
{"token": ["C1413702#ent", "<e1>", "phosphorylation", "by", "C0965618#ent", "<e2>", "was", "also", "inhibited", "by", "H-89", ",", "indicating", "that", "C0965618#ent", "<e2>", "protects", "SNP-induced", "apoptosis", "via", "PKA-dependent", "pathway", "."], "h": {"id": "C1413702", "name": "C1413702#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0965618", "name": "C0965618#ent", "pos": [4, 5]}}
{"token": ["At", "the", "same", "time", "the", "C0010531#ent", "<e1>", "phosphorylation", "of", "C1136365#ent", "<e2>", "the", "sarcolemma", "causes", "inhibition", "of", "the", "passive", "Ca2", "+", "efflux", "from", "the", "vesicles", "depending", "on", "the", "degree", "of", "membrane", "phosphorylation"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [9, 10]}}
{"token": ["Staurosporine", "induced", "recruitment", "of", "filamentous", "actin", "F-actin", ")", ",", "cortactin", ",", "filamin", ",", "Arp2/3", "complex", "C1419407#ent", "<e1>", "GTPase", "and", "phospholipase", "C-gamma1", "C0136864#ent", "<e2>", ")", "to", "lamellipodia", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0136864", "name": "C0136864#ent", "pos": [21, 22]}}
{"token": ["Here", "we", "show", "that", "the", "BCR-mediated", "C1419407#ent", "<e1>", "activation", "is", "significantly", "inhibited", "by", "loss", "of", "Btk", ",", "while", "this", "C1419407#ent", "<e1>", "activation", "is", "not", "affected", "by", "loss", "of", "phospholipase", "C-gamma2", "C0136864#ent", "<e1>", ")", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0136864", "name": "C0136864#ent", "pos": [30, 31]}}
{"token": ["Using", "a", "chlortetracycline", "assay", "we", "found", "that", "N(4)-chloroacetylcytosine", "arabinoside", "a", "C2936799#ent", "<e1>", "triggered", "rat", "sperm", "acrosome", "reaction", "whereas", "C0530715#ent", "<e2>", "a", "GABAC", "receptor", "antagonist", "inhibited", "the", "ability", "of", "N(4)-chloroacetylcytosine", "arabinoside", "induce", "acrosome", "reaction"], "h": {"id": "C2936799", "name": "C2936799#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0530715", "name": "C0530715#ent", "pos": [18, 19]}}
{"token": ["C0175697#ent", "<e1>", "fractions", "released", "by", "NHS", "or", "C0012695#ent", "<e2>", "appeared", "to", "a", "large", "degree", "to", "overlap", ",", "suggesting", "that", "NHS-mediated", "C0175697#ent", "<e1>", "release", "may", "involve", "the", "action", "of", "a", "serum", "chelator"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [7, 8]}}
{"token": ["We", "explored", "the", "involvement", "of", "C0033634#ent", "<e1>", "PKC", ")", "and", "its", "isoforms", "in", "the", "regulation", "of", "C1412115#ent", "<e2>", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412115", "name": "C1412115#ent", "pos": [16, 17]}}
{"token": ["In", "Northern", "blot", "analysis", "rat", "RNA", ",", "C0011519#ent", "<e1>", "encoding", "rat", "eek", "and", "human", "C1370600#ent", "<e2>", "hybridized", "to", "transcripts", "most", "abundant", "in", "brain", "and", "lung", ",", "respectively", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "examined", "the", "roles", "of", "the", "Walker", "A", "Walker", "B", "and", "signature", "motifs", "in", "the", "C3814821#ent", "<e1>", "NBD", ")", "of", "C1422272#ent", "<e2>", "and", "G8", "using", "recombinant", "adenoviruses", "reconstitute", "biliary", "sterol", "transport", "G5G8-deficient", "mice", "."], "h": {"id": "C3814821", "name": "C3814821#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1422272", "name": "C1422272#ent", "pos": [21, 22]}}
{"token": ["However", ",", "C2936886#ent", "<e1>", "influx-stimulated", "shedding", "of", "transforming", "growth", "factor", "alpha", "amphiregulin", "does", "not", "require", "C1412186#ent", "<e2>", ",", "even", "though", "C1412186#ent", "<e2>", "is", "essential", "for", "phorbol", "ester-stimulated", "shedding", "of", "these", "EGFR-ligands", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412186", "name": "C1412186#ent", "pos": [15, 16]}}
{"token": ["C1418245#ent", "<e1>", "copurifies", "with", "C2698835#ent", "<e2>", "alpha", "2", "12", "]", ",", "and", "with", "tubulin", ";", "it", "also", "reduces", "microtubule", "catastrophe", "in", "vitro", "13", "]", "."], "h": {"id": "C1418245", "name": "C1418245#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2698835", "name": "C2698835#ent", "pos": [4, 5]}}
{"token": ["The", "breast", "cancer", "susceptibility", "protein", "Brca2", "and", "the", "C1335609#ent", "<e1>", "Blm", "(", "Bloom", "syndrome", ")", "are", "C0079427#ent", "<e2>", "maintain", "genome", "integrity", "at", "least", "in", "part", ",", "through", "homologous", "recombination", "HR", ")", "."], "h": {"id": "C1335609", "name": "C1335609#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [16, 17]}}
{"token": ["C0033377#ent", "<e1>", ",", "hypotension", ",", "bradycardia", ",", "and", "C0234437#ent", "<e2>", "."], "h": {"id": "C0033377", "name": "C0033377#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0234437", "name": "C0234437#ent", "pos": [8, 9]}}
{"token": ["In", "the", "present", "studies", "we", "examined", "the", "influence", "of", "the", "C3536929#ent", "<e1>", "carbachol", "on", "intracellular", "pH", "(", "C1333690#ent", "<e2>", ")", "in", "chicken", "granulosa", "cells"], "h": {"id": "C3536929", "name": "C3536929#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [17, 18]}}
{"token": ["Patients", "with", "higher", "concentrations", "of", "serum", "creatinine", "C1412376#ent", "<e1>", "had", "high", "urine", "levels", "C1366571#ent", "<e2>", "."], "h": {"id": "C1412376", "name": "C1412376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [13, 14]}}
{"token": ["Mixtures", "containing", "C0020473#ent", "<e1>", "plasma", ",", "lipid", "extracts", "(", "ethanol", ":", "C0001002#ent", "<e2>", ",", "1:1", ")", "of", "C0020473#ent", "<e1>", "plasma", ",", "or", "albumin", "from", "C0020473#ent", "<e1>", "plasma", "increased", "tumor", "[3H]thymidine", "incorporation", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [11, 12]}}
{"token": ["A", "number", "of", "therapies", "have", "been", "shown", "to", "improve", "C1426102#ent", "<e1>", "signs", "and", "symptoms", ",", "but", "few", "clinical", "trials", "addressed", "C0518214#ent", "<e2>", "and", "economic", "issues"], "h": {"id": "C1426102", "name": "C1426102#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0518214", "name": "C0518214#ent", "pos": [20, 21]}}
{"token": ["Cathepsin", "B", "disintegrated", "the", "Z-line", "and", "the", "M-line", ",", "and", "induced", "C0012634#ent", "<e1>", "of", "the", "arrangement", "of", "filaments", "in", "the", "C3890553#ent", "<e2>", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3890553", "name": "C3890553#ent", "pos": [20, 21]}}
{"token": ["Paradoxically", ",", "human", "B", "cell", "C0522274#ent", "<e1>", "associated", "with", "increased", "susceptibility", "to", "viral", "and", "C0026946#ent", "<e2>", "which", "are", "T", "cell", "immunity", "infections", "."], "h": {"id": "C0522274", "name": "C0522274#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [14, 15]}}
{"token": ["Subunit", "c", "C0949692#ent", "<e1>", "accumulates", "in", "most", "of", "them", ",", "including", "the", "juvenile", "C1413495#ent", "<e2>", "form", "and", "a", "sheep", "form", "orthologous", "to", "CLN6", "."], "h": {"id": "C0949692", "name": "C0949692#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413495", "name": "C1413495#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "for", "human", "C0009021#ent", "<e1>", "in", "the", "North", "of", "Vietnam", "the", "efficacy", "of", "C0032911#ent", "<e2>", "25", "mg/kg", "o.d", "."], "h": {"id": "C0009021", "name": "C0009021#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0032911", "name": "C0032911#ent", "pos": [15, 16]}}
{"token": ["C2744579#ent", "<e1>", "was", "shown", "to", "inhibit", "the", "interaction", "of", "35", "C0072366#ent", "<e2>", "tubulin", "dimer", "polymer", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072366", "name": "C0072366#ent", "pos": [10, 11]}}
{"token": ["In", "addition", ",", "less", "common", "genetically", "determined", "associations", "like", "homocystinuria", ",", "C0039292#ent", "<e1>", "Hutchinson-Gilford", "syndrome", "progeria", ")", ",", "Werner's", "syndrome", "radiation", "induced", "C0004153#ent", "<e2>", "and", "the", "implications", "of", "Chlamydia", "pneumoniae", "the", "arterial", "wall", "discussed", "."], "h": {"id": "C0039292", "name": "C0039292#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [22, 23]}}
{"token": ["Causes", "of", "in", "the", "FSE", "follow", "global", "trends", "higher", "death", "rates", "to", "infectious", "and", "C0747256#ent", "<e1>", "poorer", "countries", ",", "and", "higher", "death", "rates", "to", "C1561643#ent", "<e2>", "wealthier", "countries", "."], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [24, 25]}}
{"token": ["Furthermore", ",", "MS", "analyses", "that", "Nedd8", "K11", ",", "K22", ",", "K48", ",", "and", "C1705592#ent", "<e1>", "can", "form", "chains", "in", "vivo", "whereas", "C1417663#ent", "<e2>", "K48", "can", "be", "neddylated", "in", "vitro"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417663", "name": "C1417663#ent", "pos": [21, 22]}}
{"token": ["With", "the", "ORF", "of", "GRA3", ",", "yeast", "two-hybrid", "assay", "performed", "in", "HeLa", "cDNA", "expression", "library", "which", "resulted", "in", "the", "interaction", "of", "GRA3", "with", "C1332660#ent", "<e1>", "CAMLG", ")", ",", "a", "C1335807#ent", "<e2>", "ER", "."], "h": {"id": "C1332660", "name": "C1332660#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1335807", "name": "C1335807#ent", "pos": [29, 30]}}
{"token": ["The", "phenotype", "of", "these", "mice", "correctly", "models", "the", "defects", "found", "in", "human", "C1844020#ent", "<e1>", "and", "indicates", "an", "important", "role", "for", "Zic3", "in", "both", "C0422885#ent", "<e2>", "and", "axial", "patterning", "."], "h": {"id": "C1844020", "name": "C1844020#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0422885", "name": "C0422885#ent", "pos": [23, 24]}}
{"token": ["Our", "results", "reveal", "a", "time-", "and", "C1420295#ent", "<e1>", "expression", "of", "C0079068#ent", "<e2>", "during", "avian", "development", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [10, 11]}}
{"token": ["These", "data", "suggest", "that", "endothelin", "acts", "as", "a", "physiological", "regulator", "TALH", "NO", "synthesis", ",", "thus", "inhibiting", "C3811086#ent", "<e1>", "contributing", "to", "the", "natriuretic", "effects", "C3273436#ent", "<e2>", "observed", "in", "vivo"], "h": {"id": "C3811086", "name": "C3811086#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [23, 24]}}
{"token": ["Comparators", "were", "first", "generation", "(", "C0008929#ent", "<e1>", ",", "tripolidine", ")", "and", "second", "generation", "terfenadine", ",", "C0055147#ent", "<e2>", ")", "antihistamines", "."], "h": {"id": "C0008929", "name": "C0008929#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0055147", "name": "C0055147#ent", "pos": [15, 16]}}
{"token": ["Various", "types", "of", "C0039730#ent", "<e1>", "are", "inherited", "C0002871#ent", "<e2>", "caused", "by", "mutations", "at", "the", "globin", "gene", "loci", "on", "chromosomes", "16", "and", "11", ",", "affecting", "the", "production", "of", "alpha-", "or", "beta-globin", "protein", "respectively", "."], "h": {"id": "C0039730", "name": "C0039730#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [7, 8]}}
{"token": ["Tuberculosis", "and", "C2350529#ent", "<e1>", "are", "two", "of", "the", "most", "common", "C0876973#ent", "<e2>", "occur", "in", "children", "."], "h": {"id": "C2350529", "name": "C2350529#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0876973", "name": "C0876973#ent", "pos": [10, 11]}}
{"token": ["Invasive", "C2350529#ent", "<e1>", "the", "most", "common", "fungal", "C0876973#ent", "<e2>", "certain", "immunocompromised", "patients", "."], "h": {"id": "C2350529", "name": "C2350529#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0876973", "name": "C0876973#ent", "pos": [7, 8]}}
{"token": ["Association", "with", "C0034665#ent", "<e1>", "is", "accelerated", "3-fold", "in", "the", "presence", "of", "C1419258#ent", "<e2>", ",", "which", "presumably", "prevents", "steric", "hindrance", "caused", "by", "the", "Ran", "C-terminus"], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419258", "name": "C1419258#ent", "pos": [11, 12]}}
{"token": ["The", "C0014740#ent", "<e1>", "persistent", ",", "overlapping", "with", "C0919615#ent", "<e2>", "."], "h": {"id": "C0014740", "name": "C0014740#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0919615", "name": "C0919615#ent", "pos": [7, 8]}}
{"token": ["Pravastatin", "and", "C0965129#ent", "<e1>", "are", "relatively", "hydrophilic", "and", "not", "significantly", "C0025517#ent", "<e2>", "by", "cytochrome", "P(450", ")", "enzymes", "."], "h": {"id": "C0965129", "name": "C0965129#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [10, 11]}}
{"token": ["In", "fact", ",", "the", "lack", "of", "interactions", "of", "C0965129#ent", "<e1>", "with", "drugs", "C0025517#ent", "<e2>", "by", "cytochrome", "P450", "3A4", "provide", "a", "safety", "advantage", "not", "shared", "by", "other", "potent", "statins", "."], "h": {"id": "C0965129", "name": "C0965129#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [12, 13]}}
{"token": ["However", ",", "limited", "data", "exist", "on", "the", "relationship", "between", "C0042384#ent", "<e1>", "the", "severity", "of", "C1847493#ent", "<e2>", "PAD", ")", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1847493", "name": "C1847493#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "alpha", "2", "beta", "1", "to", "initial", "HFK", "adhesion", "to", "laminin", "but", "C2323772#ent", "<e1>", "primarily", "responsible", "for", "long-term", "HFK", "adhesion", "to", "secreted", "laminin-containing", "C3889469#ent", "<e2>", "."], "h": {"id": "C2323772", "name": "C2323772#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3889469", "name": "C3889469#ent", "pos": [24, 25]}}
{"token": ["The", "following", "circumstantial", "evidence", "led", "to", "the", "conclusion", "that", "C3273483#ent", "<e1>", "-8212", "caused", "an", "elevated", "cyclic", "C4285220#ent", "<e2>", "level", "in", "myocardial", "cells", "producing", "the", "positive", "inotropic", "effect"], "h": {"id": "C3273483", "name": "C3273483#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4285220", "name": "C4285220#ent", "pos": [16, 17]}}
{"token": ["The", "clear", "relationship", "between", "C1416795#ent", "<e1>", "and", "bacterial", "LanC", "proteins", "similar", "functions", "as", "peptide-modifying", "enzymes", "synthesizing", "C4084937#ent", "<e2>"], "h": {"id": "C1416795", "name": "C1416795#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4084937", "name": "C4084937#ent", "pos": [16, 17]}}
{"token": ["Our", "results", "strongly", "suggest", "that", "C0028978#ent", "<e1>", "has", "a", "dual", "mechanism", "of", "action", ":", "C0071766#ent", "<e2>", "inhibition", "and", "gastric", "mucosa", "CA", "inhibition", ",", "and", "that", "these", "enzymes", "may", "be", "functionally", "coupled", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0071766", "name": "C0071766#ent", "pos": [14, 15]}}
{"token": ["Since", "this", "cytotoxic", "effector", "be", "generated", "with", "IL-2", "as", "well", "as", "with", "C1420002#ent", "<e1>", "it", "appears", "to", "be", "a", "lymphokine-activated", "killer", "C1824201#ent", "<e2>", ")", "."], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1824201", "name": "C1824201#ent", "pos": [21, 22]}}
{"token": ["C0072074#ent", "<e1>", "of", "absorption", "of", "cyclosporin", "microemulsion", "C0699605#ent", "<e2>", ")", "is", "a", "concept", "in", "therapeutic", "drug", "monitoring", "TDM", ")", "designed", "to", "further", "optimise", "the", "clinical", "benefits", "this", "formulation", "in", "transplant", "recipients", "."], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0699605", "name": "C0699605#ent", "pos": [7, 8]}}
{"token": ["The", "search", "for", "genes", "for", "OF", "should", "start", "with", "a", "significant", "h(2", ")", "for", "OF", "and", "should", "include", "risk", "factors", "besides", "C1414083#ent", "<e1>", ")", "that", "are", "C1516876#ent", "<e2>", "correlated", "with", "OF", "."], "h": {"id": "C1414083", "name": "C1414083#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [26, 27]}}
{"token": ["We", "evaluated", "the", "C1414083#ent", "<e1>", "through", "dual-energy", "X-ray", "absorptiometry", "DXA", ")", "in", "patients", "with", "C1516876#ent", "<e2>", "determined", "hypogonadism", "or", "hypogonadism", "acquired", "in", "adulthood", "."], "h": {"id": "C1414083", "name": "C1414083#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [14, 15]}}
{"token": ["The", "low-affinity", "component", "was", "present", "in", "C0014921#ent", "<e1>", "and", "PM", "livers", "and", "was", "identified", "as", "C1142644#ent", "<e2>", "."], "h": {"id": "C0014921", "name": "C0014921#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [15, 16]}}
{"token": ["Negative", "effects", "be", "observed", "in", "acute", "respiratory", "conditions", ",", "especially", "during", "acute", "exacerbations", "C3266262#ent", "<e1>", "with", "the", "administration", "of", "C0005064#ent", "<e2>", ";", "hence", "they", "should", "be", "used", "with", "caution", "."], "h": {"id": "C3266262", "name": "C3266262#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [19, 20]}}
{"token": ["Both", "C3538841#ent", "<e1>", "doses", "significantly", "shifted", "C1333673#ent", "<e2>", "secretion", "into", "later", "portions", "of", "the", "night", ",", "with", "a", "significantly", "greater", "delay", "observed", "after", "the", "larger", "dose"], "h": {"id": "C3538841", "name": "C3538841#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [6, 7]}}
{"token": ["C3541321#ent", "<e1>", "depletion", "dramatically", "increases", "apoptosis", "after", "methylating", "DNA", "damage", "impairs", "C1419240#ent", "<e2>", "focus", "formation", "in", "response", "to", "methylating", "agents", "but", "not", "after", "ionizing", "radiation"], "h": {"id": "C3541321", "name": "C3541321#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419240", "name": "C1419240#ent", "pos": [11, 12]}}
{"token": ["Progressive", "supranuclear", "palsy", "C1332754#ent", "<e1>", ")", "is", "a", "clinicopathological", "entity", "typically", "presenting", "as", "an", "C0410180#ent", "<e2>", "early", "falls", "axial", "rigidity", "vertical", "supranuclear", "gaze", "palsy", "levodopa", "resistance", "."], "h": {"id": "C1332754", "name": "C1332754#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0410180", "name": "C0410180#ent", "pos": [14, 15]}}
{"token": ["The", "C0014442#ent", "<e1>", "also", "catalyzed", "the", "hydrolysis", "of", "pNPG", ",", "amygdalin", ",", "C0061200#ent", "<e2>", "and", "salicin", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0061200", "name": "C0061200#ent", "pos": [12, 13]}}
{"token": ["Our", "results", "demonstrate", "that", "the", "soluble", "viral", "glycoprotein", "induce", "a", "specific", "C0031667#ent", "<e1>", "PLA2", ")", "activation", "in", "lymphocytes", "through", "C1332714#ent", "<e2>", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332714", "name": "C1332714#ent", "pos": [19, 20]}}
{"token": ["The", "electroencephalography", "(", "EEG", ")", ",", "sensory", "evoked", "potentials", "C1826261#ent", "<e1>", ")", ",", "sleep-wake", "rhythm", "study", "and", "polysomnography", "(", "C1418997#ent", "<e2>", ")", "study", "showed", "age-dependent", "characteristics", "."], "h": {"id": "C1826261", "name": "C1826261#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418997", "name": "C1418997#ent", "pos": [19, 20]}}
{"token": ["In", "vitro", "experiments", "showed", "that", "SPI-1", "effector", "proteins", "SipA", ",", "SopA", ",", "SopB", ",", "C0024117#ent", "<e1>", "and", "SopE2", "were", "secreted", "under", "C0253464#ent", "<e2>", "conditions", "."], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0253464", "name": "C0253464#ent", "pos": [21, 22]}}
{"token": ["C0009011#ent", "<e1>", "not", "only", "blocked", "this", "increase", "in", "C2926735#ent", "<e2>", "but", "it", "suppressed", "and/or", "abolished", "SSADs", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [8, 9]}}
{"token": ["C1538973#ent", "<e1>", "NOS", ")", "and", "C1743497#ent", "<e2>", "Mn-SOD", ")", "mRNA", "expressions", "are", "simultaneously", "induced", "by", "these", "stimulants", "in", "rat", "VSMCs", "."], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1743497", "name": "C1743497#ent", "pos": [5, 6]}}
{"token": ["Recent", "genetic", "evidence", "linked", "mutations", "in", "hTHTR1", "with", "the", "manifestation", "of", "TRMA", "(", "C4021731#ent", "<e1>", ",", "a", "condition", "also", "associated", "with", "diabetes", "mellitus", "C0018784#ent", "<e2>", "retinal", "disorders"], "h": {"id": "C4021731", "name": "C4021731#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [23, 24]}}
{"token": ["We", "report", "a", "case", "of", "systemic", "infection", "C0036117#ent", "<e1>", "virchow", "in", "a", "21-year-old", "male", "who", "subsequently", "developed", "C0267841#ent", "<e2>"], "h": {"id": "C0036117", "name": "C0036117#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0267841", "name": "C0267841#ent", "pos": [17, 18]}}
{"token": ["C1537673#ent", "<e1>", "and", "serum", "iron", "studies", ",", "C0001899#ent", "<e2>", "ALT", ")", "values", ",", "hepatitis", "C", "virus", "HCV", ")", "genotype", ",", "and", "HCV", "RNA", "determined", "prior", "to", "therapy", "."], "h": {"id": "C1537673", "name": "C1537673#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001899", "name": "C0001899#ent", "pos": [7, 8]}}
{"token": ["The", "data", "suggest", "that", "C1420041#ent", "<e1>", "may", "not", "directly", "cause", "C0018784#ent", "<e2>"], "h": {"id": "C1420041", "name": "C1420041#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [10, 11]}}
{"token": ["Although", "superficial", "siderosis", "C1420041#ent", "<e1>", ")", "has", "been", "clinically", "characterized", "as", "a", "combination", "of", "C0018784#ent", "<e2>", "cerebellar", "ataxia", "pyramidal", "signs", ",", "precise", "evaluation", "of", "the", "function", "of", "the", "eighth", "cranial", "nerve", "rarely", "been", "reported", "."], "h": {"id": "C1420041", "name": "C1420041#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "was", "conducted", "to", "determine", "if", "the", "unanticipated", "estrogenic", "effects", "produced", "by", "conversion", "of", "MT", "via", "C1366496#ent", "<e1>", "activity", "to", "17alpha-methylestradiol", "(", "C1706042#ent", "<e2>", ")", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1706042", "name": "C1706042#ent", "pos": [24, 25]}}
{"token": ["In", "prior", "studies", ",", "both", "iron", "overload", "features", "of", "AMD", "were", "identified", "in", "mice", "deficient", "in", "the", "C0007841#ent", "<e1>", "Cp", ")", "and", "its", "C1334043#ent", "<e2>", "Heph", ")", "(", "double", "knockout", "DKO", ")", "."], "h": {"id": "C0007841", "name": "C0007841#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [23, 24]}}
{"token": ["18", "C4042861#ent", "<e1>", "female", "patients", "with", "C0856727#ent", "<e2>", ",", "who", "had", "to", "undergo", "cholecystectomy", ",", "were", "divided", "into", "3", "groups", "and", "studied", "for", "a", "4-day", "period", "."], "h": {"id": "C4042861", "name": "C4042861#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0856727", "name": "C0856727#ent", "pos": [6, 7]}}
{"token": ["To", "investigate", "structure-function", "relationships", "of", "CYP11B", ",", "C2987364#ent", "<e1>", "rat", "CYP11B1", "and", "C0075233#ent", "<e2>", "and", "DR-CYP11B1", "(", "mutant", "CYP11B1", "in", "Dahl", "'s", "salt-resistant", "rats", ")", "have", "been", "successfully", "expressed", "in", "Escherichia", "coli"], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0075233", "name": "C0075233#ent", "pos": [12, 13]}}
{"token": ["In", "response", "to", "DNA", "damage", "C0036421#ent", "<e1>", "induces", "a", "growth", "arrest", "allowing", "time", "for", "C1333237#ent", "<e2>", "occur", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333237", "name": "C1333237#ent", "pos": [14, 15]}}
{"token": ["Studies", "with", "inhibitory", "antibodies", "chemical", "inhibitors", "that", "C1142644#ent", "<e1>", "the", "primary", "enzyme", "for", "oxidative", "bioactivation", "of", "I", "and", "C3273406#ent", "<e2>", "in", "human", "liver", "microsomes", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [18, 19]}}
{"token": ["C1413812#ent", "<e1>", "found", "in", "fetal", "hepatocytes", "and", "its", "C0017337#ent", "<e2>", "was", "hypomethylated", "when", "the", "expression", "of", "the", "C0017337#ent", "<e2>", "was", "elevated", "."], "h": {"id": "C1413812", "name": "C1413812#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["Patients", "with", "Rett", "syndrome", "significantly", "less", "C0033487#ent", "<e1>", "than", "control", "patients", "when", "standardized", "for", "weight", "and", "the", "C0720099#ent", "<e2>", "of", "the", "procedure", "(", "P", "=", ".004", ")", "."], "h": {"id": "C0033487", "name": "C0033487#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [17, 18]}}
{"token": ["We", "report", "on", "a", "patient", "with", "tamoxifen-induced", "acute", "pancreatitis", "and", "C0020557#ent", "<e1>", "who", "was", "successfully", "treated", "with", "insulin", "infusion", "long-term", "C0017245#ent", "<e2>", "."], "h": {"id": "C0020557", "name": "C0020557#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0017245", "name": "C0017245#ent", "pos": [20, 21]}}
{"token": ["The", "Saccharomyces", "cerevisiae", "C3538850#ent", "<e1>", "a", "guanine", "nucleotide", "exchange", "factor", "Ras", "proteins", "catalytic", "domain", "highly", "C1334043#ent", "<e2>", "to", "Ras-guanine", "nucleotide", "exchange", "factors", "higher", "eukaryotes", "."], "h": {"id": "C3538850", "name": "C3538850#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [15, 16]}}
{"token": ["Among", "patients", "with", "acute", "leukemia", "50", "%", "of", "AML", "patients", "expressed", "C1334501#ent", "<e1>", ",", "while", "the", "majority", "of", "C1704799#ent", "<e2>", "patients", "were", "negative", "."], "h": {"id": "C1334501", "name": "C1334501#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704799", "name": "C1704799#ent", "pos": [18, 19]}}
{"token": ["C2917673#ent", "<e1>", "treatment", "increased", "the", "in", "vivo", "expression", "of", "Bsep", "but", "not", "C1537665#ent", "<e2>", "or", "Oatp", "."], "h": {"id": "C2917673", "name": "C2917673#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537665", "name": "C1537665#ent", "pos": [12, 13]}}
{"token": ["Aspirin", "and", "C0070166#ent", "<e1>", "are", "proven", "to", "prevent", "thromboembolic", "events", "during", "percutaneous", "coronary", "intervention", "C1418370#ent", "<e2>", ")", "."], "h": {"id": "C0070166", "name": "C0070166#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418370", "name": "C1418370#ent", "pos": [14, 15]}}
{"token": ["The", "paper", "deals", "with", "the", "evaluation", "of", "tablets", "from", "the", "mixtures", "of", "directly", "compressible", "C0054259#ent", "<e1>", "Starch", "1500", "and", "directly", "compressible", "C0064585#ent", "<e2>", "Lacty-Tab", "in", "a", "ratio", "of", "3:1", "and", "1:1", "."], "h": {"id": "C0054259", "name": "C0054259#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0064585", "name": "C0064585#ent", "pos": [21, 22]}}
{"token": ["Low-dose", "C0031008#ent", "<e1>", "together", "with", "C1881339#ent", "<e2>", "is", "effective", "in", "the", "treatment", "of", "parkinsonism", "without", "side", "effects", "even", "in", "advanced", "stages", "the", "disease", "."], "h": {"id": "C0031008", "name": "C0031008#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1881339", "name": "C1881339#ent", "pos": [5, 6]}}
{"token": ["Solid", "dispersions", "prepared", "by", "using", "C0032479#ent", "<e1>", "PEG", "4000", ")", "and", "C0032856#ent", "<e2>", "PVP", "K30", ")", "in", "different", "drug-to-carrier", "ratios", "."], "h": {"id": "C0032479", "name": "C0032479#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032856", "name": "C0032856#ent", "pos": [11, 12]}}
{"token": ["C1413947#ent", "<e1>", "induce", "PPAR", "gamma", "mRNA", "in", "the", "absence", "of", "C0000546#ent", "<e2>", ";", "however", ",", "expression", "of", "aP2", "mRNA", "and", "maximum", "fat", "deposition", "is", "dependent", "on", "the", "PPAR", "activator", "."], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0000546", "name": "C0000546#ent", "pos": [10, 11]}}
{"token": ["Therefore", "carbon-coating", "TiO(2", ")", "was", "found", "to", "be", "advantageous", "for", "mounting", "C1166521#ent", "<e1>", "and", "its", "application", "for", "the", "C0070570#ent", "<e2>", "decomposition", "via", "photo-Fenton", "process", "."], "h": {"id": "C1166521", "name": "C1166521#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0070570", "name": "C0070570#ent", "pos": [18, 19]}}
{"token": ["These", "cytokines", "all", "together", "may", "be", "responsible", "for", "many", "clinical", "aspects", "the", "disease", "such", "as", "C0018681#ent", "<e1>", ",", "fever", ",", "anorexia", ",", "subtle", "cognitive", "changes", "motor", "disfunctions", "C1516009#ent", "<e2>", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1516009", "name": "C1516009#ent", "pos": [27, 28]}}
{"token": ["The", "activation", "of", "recombinant", "rat", "corin", "was", "inhibited", "by", "small", "molecule", "trypsin", "inhibitors", "not", "inhibitors", "for", "matrix", "metalloproteinases", "C1667078#ent", "<e1>", "suggesting", "that", "a", "C1416671#ent", "<e2>", "activated", "corin", "in", "these", "cells", "."], "h": {"id": "C1667078", "name": "C1667078#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [23, 24]}}
{"token": ["The", "administered", "anti-cancerous", "agents", "methotrexate", ",", "cis-platinum", "and", "C0085752#ent", "<e1>", ",", "and", "5-FU", "or", "C0079083#ent", "<e2>", "were", "administered", "as", "maintenance", "therapy"], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [14, 15]}}
{"token": ["We", "used", "the", "same", "model", "to", "compare", "the", "effects", "of", "C0030817#ent", "<e1>", ",", "acetylcysteine", ",", "colchicine", ",", "and", "C0040866#ent", "<e2>"], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0040866", "name": "C0040866#ent", "pos": [18, 19]}}
{"token": ["Previously", ",", "we", "have", "found", "that", "dust", "mite", "allergens", "can", "directly", "activate", "alveolar", "macrophages", "C4284022#ent", "<e1>", ")", ",", "induce", "inflammatory", "cytokines", "and", "enhance", "T-helper", "type", "2", "C1333196#ent", "<e2>", "production", "."], "h": {"id": "C4284022", "name": "C4284022#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [26, 27]}}
{"token": ["The", "reduced", "PRRSV-associated", "CPE", "in", "C4284022#ent", "<e1>", "and", "increased", "pro-inflammatory", "C1333196#ent", "<e2>", "production", "may", "lead", "to", "a", "more", "severe", "pneumonic", "lesion", "those", "dually", "infected", "pigs", "."], "h": {"id": "C4284022", "name": "C4284022#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [10, 11]}}
{"token": ["We", "have", "examined", "the", "antitumor", "activity", "NGR-TNF", "in", "combination", "with", "various", "C0033978#ent", "<e1>", "via", "different", "mechanisms", ",", "including", ",", "besides", "doxorubicin", "and", "C0025241#ent", "<e2>", ",", "cisplatin", ",", "paclitaxel", ",", "and", "gemcitabine", "."], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025241", "name": "C0025241#ent", "pos": [22, 23]}}
{"token": ["We", "describe", "a", "patient", "who", "presented", "with", "pneumothorax", "and", "C0034069#ent", "<e1>", "we", "believe", "was", "due", "to", "C0007257#ent", "<e2>", "given", "for", "bone", "marrow", "transplantation", "part", "of", "therapy", "for", "breast", "cancer"], "h": {"id": "C0034069", "name": "C0034069#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007257", "name": "C0007257#ent", "pos": [16, 17]}}
{"token": ["A", "pediatric", "patient", "is", "reported", "who", "experienced", "fatal", "progressive", "C0034069#ent", "<e1>", "a", "complication", "of", "C0007257#ent", "<e2>", "(", "BCNU", ")", "therapy", "."], "h": {"id": "C0034069", "name": "C0034069#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007257", "name": "C0007257#ent", "pos": [14, 15]}}
{"token": ["Significant", "laboratory", "findings", "included", "elevated", "plasma", "levels", "of", "creatine", "phosphokinase", "acyl-carnitine", "and", "a", "C2711227#ent", "<e1>", "biopsy", "suggesting", "a", "diagnosis", "of", "C3887523#ent", "<e2>"], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C3887523", "name": "C3887523#ent", "pos": [20, 21]}}
{"token": ["These", "findings", "together", "suggest", "that", "C0599532#ent", "<e1>", "antioxidant", "reversal", "of", "PDTC", "actions", "on", "AP-1", "and", "C1417708#ent", "<e2>", "is", "independent", "of", "their", "established", "roles", "in", "scavenging", "oxygen", "free", "radicals", "repleting", "the", "cellular", "glutathione", "content", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [15, 16]}}
{"token": ["We", "have", "cloned", "and", "sequenced", "the", "C1434353#ent", "<e1>", "isolated", "and", "sequenced", "its", "C1334043#ent", "<e2>", "from", "Saccharomyces", "cerevisiae", "designated", "RHC18", "."], "h": {"id": "C1434353", "name": "C1434353#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}}
{"token": ["Levels", "of", "C1416524#ent", "<e1>", "and", "transglutaminase", "mRNA", "and", "protein", "were", "induced", "by", "C0055909#ent", "<e2>", "keratinocytes", "incubated", "in", "1.2", "mM", "calcium", ",", "a", "concentration", "which", "by", "itself", "induces", "keratinocyte", "differentiation", "."], "h": {"id": "C1416524", "name": "C1416524#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0055909", "name": "C0055909#ent", "pos": [12, 13]}}
{"token": ["S1P", "and", "PGE2", "promote", "the", "direct", "interaction", "of", "CREB", "and", "LRH-1", ",", "which", "is", "potentiated", "by", "C/EBPdelta", "and", "the", "C0256079#ent", "<e1>", "CBP", ")", ",", "and", "steroid", "receptor", "coactivator-3", "C1334868#ent", "<e2>", ")", "."], "h": {"id": "C0256079", "name": "C0256079#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1334868", "name": "C1334868#ent", "pos": [28, 29]}}
{"token": ["The", "results", "demonstrated", "the", "predominant", "expression", "of", "ADAMTS4", "in", "osteoarthritic", "cartilage", "while", "C1412211#ent", "<e1>", "was", "constitutively", "expressed", "in", "C0949690#ent", "<e2>", "and", "normal", "cartilage"], "h": {"id": "C1412211", "name": "C1412211#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [18, 19]}}
{"token": ["Isolation", "of", "gamma-PAK", "cDNAs", "show", "that", "the", "C0211705#ent", "<e1>", "is", "highly", "conserved", "with", "C0299856#ent", "<e2>", "in", "both", "the", "p2", "binding", "kinase", "domains"], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0299856", "name": "C0299856#ent", "pos": [13, 14]}}
{"token": ["Strong", "association", "of", "C0079225#ent", "<e1>", "the", "VLDL-lipoprotein", "lipase", "complex", "was", "demonstrated", "by", "gel", "filtration", "BioGel", "A-5", "m", ",", "although", "C0079225#ent", "<e1>", "not", "bind", "to", "VLDL", "and", "only", "very", "slightly", "to", "C1416902#ent", "<e1>"], "h": {"id": "C0079225", "name": "C0079225#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [30, 31]}}
{"token": ["Amino", "acid", "sequence", "alignment", "of", "the", "amino-terminal", "of", "thrombomodulin", "C1419333#ent", "<e1>", "the", "hepatic", "asialoglycoprotein", "receptor", "that", "these", "proteins", "are", "C1512488#ent", "<e2>", "."], "h": {"id": "C1419333", "name": "C1419333#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [19, 20]}}
{"token": ["Cerebral", "damage", "the", "sensors", "responsible", "for", "the", "osmotic", "regulation", "water", "intake", "C0001942#ent", "<e1>", "release", "may", "result", "in", "hypo-", "or", "C0277967#ent", "<e2>", "associated", "with", "latent", "diabetes", "insipidus", "and", "is", "apparently", "the", "ultimate", "cause", "of", "\"", "essential", "\"", "hypernatremia", "."], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0277967", "name": "C0277967#ent", "pos": [19, 20]}}
{"token": ["Of", "the", "other", "complement", "regulatory", "proteins", "expressed", "by", "PMN", ",", "only", "C1413230#ent", "<e1>", "colocalized", "with", "CR1", ",", "while", "CD55", "and", "C1824669#ent", "<e2>", "were", "almost", "absent", "."], "h": {"id": "C1413230", "name": "C1413230#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1824669", "name": "C1824669#ent", "pos": [20, 21]}}
{"token": ["The", "article", "deals", "with", "brain", "blood", "flow", "autoregulation", "evaluated", "through", "transcranial", "Doppler", "study", "dust", "bronchitis", "patients", "with", "early", "C0007775#ent", "<e1>", "dependence", "on", "presence", "or", "absence", "of", "C0264490#ent", "<e2>"], "h": {"id": "C0007775", "name": "C0007775#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [26, 27]}}
{"token": ["C0012739#ent", "<e1>", "localized", "in", "C0268731#ent", "<e2>", "is", "of", "pathologic", "importance", "in", "human", "and", "experimental", "GN"], "h": {"id": "C0012739", "name": "C0012739#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [4, 5]}}
{"token": ["However", ",", "the", "Dictyostelium", "protein", "a", "slightly", "higher", "level", "of", "identity", "to", "the", "C0081947#ent", "<e1>", "to", "the", "C2002328#ent", "<e2>", "is", "smaller", "than", "any", "of", "the", "C2002328#ent", "<e2>", "far", "identified", "."], "h": {"id": "C0081947", "name": "C0081947#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2002328", "name": "C2002328#ent", "pos": [17, 18]}}
{"token": ["Lovastatin", "treatment", "induced", "NO", "by", "increasing", "NF-kappaB", "translocation", "its", "association", "with", "the", "CREB-binding", "protein", "CBP/p300", ")", "via", "the", "downregulation", "of", "RhoA.", "Inhibition", "of", "C0812234#ent", "<e1>", "resulted", "in", "increased", "activation", "of", "C1704987#ent", "<e2>", "."], "h": {"id": "C0812234", "name": "C0812234#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1704987", "name": "C1704987#ent", "pos": [30, 31]}}
{"token": ["The", "cultures", "on", "glass", "coverslips", "were", "stained", "with", "osteoclast-associated", "markers", ",", "tartrate-resistant", "acid", "phosphatase", "TRAP", ")", ",", "and", "vitronectin", "receptor", "C1706542#ent", "<e1>", ")", ",", "as", "well", "as", "macrophage-associated", "markers", "C1366562#ent", "<e2>", "and", "CD14", "."], "h": {"id": "C1706542", "name": "C1706542#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1366562", "name": "C1366562#ent", "pos": [29, 30]}}
{"token": ["Proteins", "identified", "that", "have", "not", "previously", "been", "identified", "directly", "from", "C1414863#ent", "<e1>", "sap", "included", "a", "glycine-rich", "RNA-binding", "protein", "metallothionein", ",", "phosphoglycerate", "mutase", "and", "C0031691#ent", "<e2>"], "h": {"id": "C1414863", "name": "C1414863#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031691", "name": "C0031691#ent", "pos": [23, 24]}}
{"token": ["Whereas", ",", "the", "elevated", "SOD", ",", "POD", "and", "C1332102#ent", "<e1>", "activity", "due", "to", "C1333690#ent", "<e2>", "depended", "on", "salinity", "environment", "."], "h": {"id": "C1332102", "name": "C1332102#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [13, 14]}}
{"token": ["In", "human", "tonsillar", "tissue", "this", "vaccine", "strain", "infects", "naive", "(", "CD45RA(+)CD62L(+", ")", ")", "T", "lymphocytes", "which", "express", "C1420084#ent", "<e1>", "very", "infrequently", ",", "with", "much", "higher", "efficiency", "than", "do", "C2987364#ent", "<e2>", "strains", "."], "h": {"id": "C1420084", "name": "C1420084#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [28, 29]}}
{"token": ["Our", "first", "goal", "was", "to", "describe", "tobacco", "and", "alcohol", "use", "and", "after", "lung", "transplant", "patients", "with", "C0010674#ent", "<e1>", "CF", ")", "and", "other", "C0034072#ent", "<e2>", "non-CF", ")", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [16, 17]}, "relation": "has_manifestation", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [22, 23]}}
{"token": ["TNF-alpha", "promoter-driven", "transcription", "by", "C0211705#ent", "<e1>", "partially", "mediated", "by", "C1334474#ent", "<e2>", "is", "cyclosporin", "A-resistant", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [9, 10]}}
{"token": ["C1313497#ent", "<e1>", "are", "synthesized", "as", "inactive", "C1258127#ent", "<e2>", "with", "an", "amino-terminal", "prodipeptide", "which", "is", "processed", "during", "transport", "of", "granzymes", "to", "the", "cytotoxic", "granules", "where", "they", "are", "stored", "as", "active", "proteinases"], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1258127", "name": "C1258127#ent", "pos": [6, 7]}}
{"token": ["SFA", "interacts", "with", "high", "affinity", "with", "the", "C0751039#ent", "<e1>", "binding", "side", "of", "CypA", "and", "inhibits", "its", "C1422813#ent", "<e2>", "activity", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422813", "name": "C1422813#ent", "pos": [16, 17]}}
{"token": ["The", "C0235222#ent", "<e1>", "independent", "of", "salt", "uptake", "can", "not", "be", "controlled", "by", "C0037982#ent", "<e2>", "but", "is", "inhibited", "by", "a", "GC", "antagonist", "such", "as", "RU486", "."], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [12, 13]}}
{"token": ["Drosophila", "Tid56", "and", "its", "human", "C1334043#ent", "<e1>", "hTid-1", "represent", "members", "of", "the", "C3539697#ent", "<e2>", "molecular", "chaperones"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539697", "name": "C3539697#ent", "pos": [12, 13]}}
{"token": ["Induction", "of", "apoptosis", "was", "also", "observed", "in", "C1704969#ent", "<e1>", "treated", "with", "flavopiridol", ",", "as", "measured", "by", "DNA", "laddering", "and", "C1538577#ent", "<e2>", "cleavage", "."], "h": {"id": "C1704969", "name": "C1704969#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538577", "name": "C1538577#ent", "pos": [19, 20]}}
{"token": ["Finally", ",", "while", "uterine", "gland", "C2984892#ent", "<e1>", "is", "slightly", "retarded", "by", "OVS", "+", "/-", "C1414571#ent", "<e2>", ",", "estrogens", "from", "these", "organs", "do", "not", "induce", "uterine", "differentiation"], "h": {"id": "C2984892", "name": "C2984892#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414571", "name": "C1414571#ent", "pos": [14, 15]}}
{"token": ["Beetles", "reared", "on", "C0885100#ent", "<e1>", "had", "greater", "weights", "and", "fecundity", "and", "a", "shorter", "larval", "C0720099#ent", "<e2>", "relative", "to", "the", "pollen-fed", "beetles", "."], "h": {"id": "C0885100", "name": "C0885100#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [14, 15]}}
{"token": ["The", "levels", "of", "F-2,6-BP", "are", "maintained", "by", "a", "family", "of", "bifunctional", "enzymes", ",", "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase", "(", "PFKFB", "or", "C3540810#ent", "<e1>", ")", ",", "which", "have", "both", "C0031727#ent", "<e2>", "and", "phosphatase", "activities", "."], "h": {"id": "C3540810", "name": "C3540810#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [24, 25]}}
{"token": ["Surprisingly", ",", "these", "IL-5", "C0039902#ent", "<e1>", "mice", "showed", "lower", "airway", "reactivity", "to", "C0600370#ent", "<e2>", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [12, 13]}}
{"token": ["Three", "groups", "of", "signalling", "proteins", "be", "discriminated", ":", "whereas", "the", "feedback", "inhibitors", "SOCS1", ",", "C1426207#ent", "<e1>", "and", "SOCS3", "are", "very", "short-lived", ",", "C1335872#ent", "<e2>", ",", "STAT3", "and", "SHP2", "have", "an", "extremely", "slow", "turnover", "rate"], "h": {"id": "C1426207", "name": "C1426207#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335872", "name": "C1335872#ent", "pos": [22, 23]}}
{"token": ["The", "prevalence", "and", "severity", "of", "C0011334#ent", "<e1>", "found", "to", "be", "highest", "in", "the", "C0007789#ent", "<e2>", "group", "and", "lowest", "in", "the", "blind", "group"], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007789", "name": "C0007789#ent", "pos": [13, 14]}}
{"token": ["Thereafter", ",", "C1538051#ent", "<e1>", "immunoreactivity", "and", "protein", "level", "the", "C1428890#ent", "<e2>", "were", "decreased", "with", "time", "after", "ischemia/reperfusion", "."], "h": {"id": "C1538051", "name": "C1538051#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1428890", "name": "C1428890#ent", "pos": [9, 10]}}
{"token": ["This", "report", "aimed", "at", "showing", "a", "case", "of", "C0026896#ent", "<e1>", "patient", "submitted", "to", "thymectomy", "under", "total", "intravenous", "anesthesia", "C0033487#ent", "<e2>", "and", "remifentanil", "."], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0033487", "name": "C0033487#ent", "pos": [18, 19]}}
{"token": ["C0022956#ent", "<e1>", "activated", "NF-kappaB", "p65", "increased", "ICAM-1", "expression", "in", "C0003364#ent", "<e2>", "which", "was", "inhibited", "by", "N-acetylcysteine", "."], "h": {"id": "C0022956", "name": "C0022956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [9, 10]}}
{"token": ["This", "study", "examined", "the", "temporal", "and", "spatial", "characteristics", "of", "C0006784#ent", "<e1>", "activity", "after", "transient", "forebrain", "ischemia", "C1420705#ent", "<e2>", ")", "in", "rats", "."], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420705", "name": "C1420705#ent", "pos": [16, 17]}}
{"token": ["Lymphangioleiomyomatosis", "(", "LAM", ")", "and", "multifocal", "micronodular", "pneumocyte", "hyperplasia", "(", "C0623362#ent", "<e1>", ")", "produce", "cystic", "and", "C0028887#ent", "<e2>", "respectively", ",", "in", "the", "lungs", "of", "patients", "with", "tuberous", "sclerosis"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0028887", "name": "C0028887#ent", "pos": [16, 17]}}
{"token": ["We", "describe", "the", "case", "of", "an", "acromegalic", "woman", "with", "primary", "infertility", "was", "treated", "with", "C0086213#ent", "<e1>", ",", "and", "subsequently", "developed", "C0032001#ent", "<e2>"], "h": {"id": "C0086213", "name": "C0086213#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032001", "name": "C0032001#ent", "pos": [20, 21]}}
{"token": ["Buthionine", "sulfoximine", "pretreatment", "also", "increased", "the", "number", "of", "camptothecin-induced", "DNA-protein", "crosslinks", ",", "indicating", "that", "C1260386#ent", "<e1>", "affects", "the", "mechanism", "of", "action", "of", "C0594375#ent", "<e2>", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [22, 23]}}
{"token": ["One-Step", "Dry-Coated", "tablets", "(", "OSDrC", ")", "of", "a", "colon-targeting", "drug", "prepared", "using", "C2827264#ent", "<e1>", "Eud-L", ")", "and", "chitosan", "(", "C3889440#ent", "<e2>", ")", "as", "the", "outer", "layer"], "h": {"id": "C2827264", "name": "C2827264#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3889440", "name": "C3889440#ent", "pos": [19, 20]}}
{"token": ["The", "age-related", "prevalence", "of", "C0259749#ent", "<e1>", "at", "age", "40", "-", "49", "years", "while", "C0235025#ent", "<e2>", "increased", "progressively", "with", "age", "(", "p", "<", "0.001", ")", "."], "h": {"id": "C0259749", "name": "C0259749#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0235025", "name": "C0235025#ent", "pos": [13, 14]}}
{"token": ["Minocycline", "is", "an", "oral", "antibiotic", "prescribed", "throughout", "the", "world", ",", "primarily", "for", "the", "treatment", "of", "C0702166#ent", "<e1>", "other", "uses", "include", "the", "treatment", "of", "C0035854#ent", "<e2>", "and", "perioral", "dermatitis"], "h": {"id": "C0702166", "name": "C0702166#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0035854", "name": "C0035854#ent", "pos": [23, 24]}}
{"token": ["However", ",", "in", "hearts", "from", "burn", "rats", ",", "leucine", "acutely", "reversed", "the", "alterations", "in", "C1414351#ent", "<e1>", "distribution", "as", "well", "as", "the", "changes", "in", "C1861424#ent", "<e2>", ",", "eIF4G", "and", "mTOR", "phosphorylation", "."], "h": {"id": "C1414351", "name": "C1414351#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1861424", "name": "C1861424#ent", "pos": [23, 24]}}
{"token": ["C0700583#ent", "<e1>", "investigated", "in", "the", "treatment", "of", "C3495559#ent", "<e2>", "JRA", ")", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C3495559", "name": "C3495559#ent", "pos": [7, 8]}}
{"token": ["To", "examine", "whether", "patients", "with", "C0003873#ent", "<e1>", "RA", ")", "with", "co-morbid", "cardiovascular", "disease", "C0007222#ent", "<e2>", ")", "have", "different", "psychological", "morbidity", "and", "psychosocial", "risk", "factors", "it", ")", "compared", "with", "RA", "patients", "without", "co-morbid", "C0007222#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [13, 14]}}
{"token": ["With", "these", "C1710463#ent", "<e1>", "properties", "the", "C1709313#ent", "<e2>", "the", "cell", "'s", "metabolism", ",", "which", "enables", "them", "to", "induce", "oncogenic", "transformation", "rodent", "cells"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [6, 7]}}
{"token": ["The", "domains", "in", "C1709313#ent", "<e1>", "that", "are", "essential", "for", "this", "C1710463#ent", "<e2>", "also", "required", "for", "the", "transforming", "properties", "of", "C1709313#ent", "<e1>", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [3, 4]}}
{"token": ["The", "clinical", "examination", "generalized", "slowing", "EEG", ",", "mixed", "sensory", "C0235025#ent", "<e1>", "EMG", ",", "thick", "skull", ",", "both", "C4023018#ent", "<e2>", "ventricular", "dilatation", "computed", "tomography", "marked", "decrease", "in", "cerebrospinal", "homovanillic", "acid", "content", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4023018", "name": "C4023018#ent", "pos": [17, 18]}}
{"token": ["The", "episodic", "manifestations", "in", "both", "patients", "were", "associated", "with", "acute", ",", "resolving", "C0221505#ent", "<e1>", "magnetic", "resonance", "imaging", "or", "preceding", "the", "classical", "demyelinating", "lesions", "of", "C1539265#ent", "<e2>", "."], "h": {"id": "C0221505", "name": "C0221505#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539265", "name": "C1539265#ent", "pos": [24, 25]}}
{"token": ["B.", "burgdorferi", "also", "contains", "a", "gene", "(", "BB0721", ")", "with", "significant", "identity", "to", "the", "gene", "(", "C0796254#ent", "<e1>", ")", "encoding", "phosphatidylglycerolphosphate", "synthase", "an", "C0014442#ent", "<e2>", "in", "the", "synthetic", "pathway", "PG", "."], "h": {"id": "C0796254", "name": "C0796254#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [23, 24]}}
{"token": ["However", ",", "an", "effect", "of", "prostaglandins", "(", "C0796254#ent", "<e1>", ")", "on", "the", "activity", "of", "this", "C0014442#ent", "<e2>", "has", "not", "been", "demonstrated", "previously", "."], "h": {"id": "C0796254", "name": "C0796254#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["The", "Authors", "'", "intraoperative", "diagnostic", "experience", "in", "C0030286#ent", "<e1>", "reported", ":", "23", "exocrine", "and", "endocrine", "neoplasms", "3", "chronic", "pancreatitis", "8", "C0030305#ent", "<e2>", "cases", "are", "discussed", "."], "h": {"id": "C0030286", "name": "C0030286#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "the", "measurement", "of", "pancreatic", "elastase", "either", "blood", "or", "ascitic", "fluid", "radioimmunoassay", "is", "a", "useful", "diagnostic", "method", "C0030286#ent", "<e1>", "especially", "in", "C0030305#ent", "<e2>"], "h": {"id": "C0030286", "name": "C0030286#ent", "pos": [20, 21]}, "relation": "related_to", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [24, 25]}}
{"token": ["Resembling", "block", "by", "these", "C0991617#ent", "<e1>", ",", "block", "of", "C3538758#ent", "<e2>", ",", "Na(V)1.5", ",", "and", "Na(V)1.7", "by", "BPBTS", "was", "found", "to", "be", "voltage-", "and", "use-dependent", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538758", "name": "C3538758#ent", "pos": [9, 10]}}
{"token": ["Resembling", "block", "by", "these", "C0991617#ent", "<e1>", ",", "block", "of", "Na(V)1.2", ",", "C3538758#ent", "<e2>", ",", "and", "Na(V)1.7", "by", "BPBTS", "was", "found", "to", "be", "voltage-", "and", "use-dependent", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538758", "name": "C3538758#ent", "pos": [11, 12]}}
{"token": ["Since", "carbachol", ",", "CCK-8", ",", "and", "A23187", ",", "which", "are", "believed", "to", "act", "via", "C0248868#ent", "<e1>", ",", "also", "stimulated", "C0077923#ent", "<e2>", "this", "system", ",", "too", ",", "presumably", "plays", "a", "substantial", "role", "."], "h": {"id": "C0248868", "name": "C0248868#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0077923", "name": "C0077923#ent", "pos": [19, 20]}}
{"token": ["A", "four-generation", "pedigree", "exhibiting", "early-onset", "C1843013#ent", "<e1>", "AD", ")", "with", "spastic", "paraplegia", "C0393593#ent", "<e2>", ",", "and", "dysarthria", "due", "to", "a", "novel", "6-nucleotide", "insertional", "mutation", "in", "exon", "3", "the", "presenilin", "1", "gene", "PS1", ")", "is", "described", "."], "h": {"id": "C1843013", "name": "C1843013#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [12, 13]}}
{"token": ["C1427627#ent", "<e1>", "to", "the", "migration", "of", "the", "growth", "cone", "the", "C1705504#ent", "<e2>", "of", "an", "extending", "neurite", ",", "a", "process", "that", "guides", "the", "neurite", "to", "its", "destination", "during", "neural", "development", "regeneration", "(", "2", ")", "."], "h": {"id": "C1427627", "name": "C1427627#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705504", "name": "C1705504#ent", "pos": [10, 11]}}
{"token": ["A", "four-year-old", "boy", "with", "C0394007#ent", "<e1>", "marked", "myoglobinemia", "and", "developed", "C3854173#ent", "<e2>"], "h": {"id": "C0394007", "name": "C0394007#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [10, 11]}}
{"token": ["Culture", "supernatants", "from", "Treponema", "maltophilum", "associated", "with", "C0001342#ent", "<e1>", "in", "humans", "and", "Treponema", "brennaborense", "in", "a", "bovine", "cattle", "disease", "with", "C1516009#ent", "<e2>", "caused", "a", "dose-dependent", "TNF-alpha", "synthesis", "in", "human", "monocytes", "increasing", "with", "culture", "time"], "h": {"id": "C0001342", "name": "C0001342#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516009", "name": "C1516009#ent", "pos": [20, 21]}}
{"token": ["The", "NF-kappaB", "inhibition", "C1705265#ent", "<e1>", "transactivation", "was", "likely", "due", "to", "the", "competition", "of", "p65", "for", "C1705265#ent", "<e1>", "binding", "with", "C1422492#ent", "<e1>", "."], "h": {"id": "C1705265", "name": "C1705265#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [19, 20]}}
{"token": ["Three", "parotid", "salivary", "fractions", "the", "high-molecular-weight", ",", "C1424869#ent", "<e1>", "PRP", ")", ",", "and", "statherin", "fractions", ",", "promote", "C1825858#ent", "<e2>", "beta-sensitive", "adherence", "of", "strain", "12104", ",", "whereas", "only", "the", "high-molecular-weight", "fraction", "submaxillary", "saliva", "such", "adherence", "."], "h": {"id": "C1424869", "name": "C1424869#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1825858", "name": "C1825858#ent", "pos": [17, 18]}}
{"token": ["C0001911#ent", "<e1>", "proved", "as", "effective", "as", "metronidazole", "in", "the", "treatment", "of", "C0017536#ent", "<e2>", "children", "with", "the", "added", "advantage", "of", "the", "absence", "of", "anorexia", "."], "h": {"id": "C0001911", "name": "C0001911#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0017536", "name": "C0017536#ent", "pos": [11, 12]}}
{"token": ["Upon", "stimulation", "of", "platelets", "with", "C1414504#ent", "<e1>", ",", "the", "rapid", "and", "complete", "translocation", "of", "C0250935#ent", "<e2>", "away", "from", "Lyn", "caused", "concomitant", "activation", "of", "Lyn", "."], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0250935", "name": "C0250935#ent", "pos": [14, 15]}}
{"token": ["Alfentanil", ",", "an", "C0002772#ent", "<e1>", "used", "in", "the", "critical", "care", "patients", "with", "C0036690#ent", "<e2>", ",", "has", "been", "shown", "to", "enhance", "ventricular", "contractility"], "h": {"id": "C0002772", "name": "C0002772#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [12, 13]}}
{"token": ["The", "presence", "of", "the", "C1417453#ent", "<e1>", "and", "pen", "genes", "in", "increased", "resistance", "to", "C0030841#ent", "<e2>"], "h": {"id": "C1417453", "name": "C1417453#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030841", "name": "C0030841#ent", "pos": [13, 14]}}
{"token": ["C0724636#ent", "<e1>", "Ethmozine", ")", ",", "a", "relatively", "unknown", "C0003195#ent", "<e2>", "France", ",", "is", "a", "derivative", "of", "Phenothiazine", ",", "related", "to", "the", "Vaughan-Williams", "Class", "IB", "drugs", "."], "h": {"id": "C0724636", "name": "C0724636#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [8, 9]}}
{"token": ["Curcumin", ",", "C0615748#ent", "<e1>", "C4055175#ent", "<e2>", ",", "bis", "demethoxy", "C4055175#ent", "<e2>", "and", "diacetyl", "C4055175#ent", "<e2>", "inhibited", "nitrite", "induced", "oxidation", "of", "hemoglobin", "in", "both", "erythrocytes", "and", "purified", "human", "hemoglobin", "."], "h": {"id": "C0615748", "name": "C0615748#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4055175", "name": "C4055175#ent", "pos": [4, 5]}}
{"token": ["C1413226#ent", "<e1>", "expression", "was", "increased", "24", "h", "after", "the", "initial", "C1705750#ent", "<e2>", "infusion", "and", "peaked", "within", "1", "week", "."], "h": {"id": "C1413226", "name": "C1413226#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705750", "name": "C1705750#ent", "pos": [10, 11]}}
{"token": ["Both", "C1419866#ent", "<e1>", "mRNA", "and", "protein", "were", "detected", "in", "the", "spinal", "cord", "C3273601#ent", "<e2>", "and", "were", "expressed", "clearly", "at", "P7", "in", "motor", "neurons"], "h": {"id": "C1419866", "name": "C1419866#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273601", "name": "C3273601#ent", "pos": [12, 13]}}
{"token": ["Phenylketonuria", "(", "PKU", ")", "and", "benign", "hyperphenylalaninaemia", "C1367469#ent", "<e1>", ")", "result", "from", "a", "variety", "of", "mutations", "in", "the", "C0017337#ent", "<e2>", "for", "the", "hepatic", "enzyme", "phenylalanine", "hydroxylase"], "h": {"id": "C1367469", "name": "C1367469#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["Total", "number", "of", "lymphocytes", ",", "CD21", "+", "B", "cells", "and", "CD4+", "T", "cells", "ileal", "Peyer", "patches", "were", "not", "significantly", "different", "in", "C0162429#ent", "<e1>", "pigs", "fed", "with", "C0050407#ent", "<e2>", "and", "in", "healthy", "pigs", "."], "h": {"id": "C0162429", "name": "C0162429#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0050407", "name": "C0050407#ent", "pos": [26, 27]}}
{"token": ["Thus", ",", "C1415619#ent", "<e1>", "plays", "a", "key", "role", "during", "C0026946#ent", "<e2>", "plants", ",", "but", "not", "of", "mammalian", "hosts", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [9, 10]}}
{"token": ["Although", "NF-kappaB", "appears", "to", "stimulate", "the", "expression", "of", "specific", "C0033613#ent", "<e1>", "neither", "the", "identities", "of", "these", "C1417679#ent", "<e2>", "nor", "the", "precise", "role", "of", "IAP", "proteins", "this", "anti-apoptotic", "process", "known", "."], "h": {"id": "C0033613", "name": "C0033613#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [16, 17]}}
{"token": ["Norfloxacin", "was", "at", "least", "as", "effective", "as", "currently", "used", "agents", "in", "treating", "urinary", "tract", "infections", "and", ",", "in", "limited", "studies", ",", "bacterial", "gastroenteritis", "C0018081#ent", "<e1>", ",", "bacterial", "prostatitis", "and", "prevention", "of", "gram-negative", "bacillary", "infection", "C0027947#ent", "<e2>", "patients", "."], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [34, 35]}}
{"token": ["It", "was", "synthesized", "in", "four", "steps", "starting", "from", "C1660063#ent", "<e1>", "and", "was", "converted", "to", "its", "C1099664#ent", "<e2>", "as", "to", "afford", "efficient", "cross-linking", "in", "an", "aqueous", "medium", "."], "h": {"id": "C1660063", "name": "C1660063#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1099664", "name": "C1099664#ent", "pos": [15, 16]}}
{"token": ["To", "assess", "the", "efficacy", "of", "the", "phosphodiesterase", "5", "inhibitor", "C0963941#ent", "<e1>", ",", "in", "selective", "C2911696#ent", "<e2>", "rat", "erectile", "dysfunction", "by", "measuring", "intracavernous", "pressure", "ICP", ")", "."], "h": {"id": "C0963941", "name": "C0963941#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2911696", "name": "C2911696#ent", "pos": [14, 15]}}
{"token": ["The", "highest", "levels", "of", "IgE", "were", "detected", "in", "the", "culture", "supernatants", "of", "MLN", "cells", "infection", ":", "IgE", "levels", "were", "modest", "in", "C1418650#ent", "<e1>", "and", "negligible", "in", "C0037982#ent", "<e2>", "."], "h": {"id": "C1418650", "name": "C1418650#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [26, 27]}}
{"token": ["Cas", "(", "Crk-associated", "substrate", "and", "C2348445#ent", "<e1>", "(", "human", "enhancer", "of", "filamentation", ")", "are", "related", "C1332163#ent", "<e2>", "function", "in", "integrin-mediated", "cell", "adhesion", "antigen", "receptor", "signaling", "pathways"], "h": {"id": "C2348445", "name": "C2348445#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332163", "name": "C1332163#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "forskolin", "(", "10(-4", ")", "and", "10(-5", ")", "mol/L", ")", ",", "an", "C1422492#ent", "<e1>", "of", "adenylate", "cyclase", "reduced", "PDGF-induced", "C3273436#ent", "<e2>", "production", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3273436", "name": "C3273436#ent", "pos": [20, 21]}}
{"token": ["Levels", "of", "catecholamines", "and", "C1420718#ent", "<e1>", "immunoreactivity", "were", "dramatically", "reduced", "in", "the", "SG", "and", "the", "C1567075#ent", "<e2>", "but", "not", "in", "the", "SCG", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1567075", "name": "C1567075#ent", "pos": [15, 16]}}
{"token": ["Of", "nine", "subjects", "tested", "with", "C3539618#ent", "<e1>", ",", "three", "gave", "C0004096#ent", "<e2>", "and", "all", "three", "also", "reacted", "to", "TDI", "and", "MDI", "."], "h": {"id": "C3539618", "name": "C3539618#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [10, 11]}}
{"token": ["C0342288#ent", "<e1>", "is", "a", "fatal", "disorder", "characterized", "by", "immune", "dysregulation", "polyendocrinopathy", ",", "C0021831#ent", "<e2>", "and", "X-linked", "inheritance", "MIM", "304930", ")", "."], "h": {"id": "C0342288", "name": "C0342288#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0021831", "name": "C0021831#ent", "pos": [12, 13]}}
{"token": ["Four", "of", "the", "C2936526#ent", "<e1>", "dolasetron", ",", "ondansetron", ",", "C0220578#ent", "<e2>", ",", "and", "tropisetron", ")", "are", "metabolized", "in", "various", "degrees", "via", "CYP2D6", ",", "an", "isoform", "subject", "to", "marked", "genetic", "polymorphism"], "h": {"id": "C2936526", "name": "C2936526#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0220578", "name": "C0220578#ent", "pos": [9, 10]}}
{"token": ["The", "NP185-clathrin", "light", "chain", "complex", "was", "associated", "with", "C0054846#ent", "<e1>", ",", "which", ",", "in", "the", "presence", "of", "C0032518#ent", "<e2>", ",", "phosphorylated", "clathrin", "light", "chain", "b", "but", "not", "the", "NP185", "."], "h": {"id": "C0054846", "name": "C0054846#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032518", "name": "C0032518#ent", "pos": [17, 18]}}
{"token": ["The", "finding", "that", "atropine", "and", "vagotomy", "increased", "latency", "of", "response", "to", "intraduodenal", "C0002763#ent", "<e1>", "indicates", "that", "a", "vagovagal", "cholinergic", "reflex", "mediates", "the", "early", "C0920330#ent", "<e2>", "to", "intestinal", "C0002763#ent", "<e1>", "."], "h": {"id": "C0002763", "name": "C0002763#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0920330", "name": "C0920330#ent", "pos": [23, 24]}}
{"token": ["C3280011#ent", "<e1>", "BCS", ")", "is", "an", "autosomal-recessive", "disorder", "by", "a", "C1096274#ent", "<e2>", "tends", "to", "perforate", ",", "causing", "progressive", "visual", "loss", "blindness", "."], "h": {"id": "C3280011", "name": "C3280011#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C1096274", "name": "C1096274#ent", "pos": [10, 11]}}
{"token": ["In", "vitro", "studies", "demonstrated", "a", "significant", "decrease", "in", "proliferative", "responses", "to", "the", "C1419428#ent", "<e1>", "in", "lymph", "node", "cells", "draining", "the", "site", "of", "immunization", "from", "C0342895#ent", "<e2>", "vs", "nonfed", "animals"], "h": {"id": "C1419428", "name": "C1419428#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [24, 25]}}
{"token": ["However", ",", "none", "of", "the", "14", "cases", "of", "nontumorous", "liver", "samples", "(", "i.e.", ",", "normal", "parenchyma", "steatosis", ",", "and", "nonspecific", "reactive", "and", "C0524909#ent", "<e1>", "showed", "detectable", "levels", "of", "C0042071#ent", "<e2>", "mRNA", "."], "h": {"id": "C0524909", "name": "C0524909#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [28, 29]}}
{"token": ["Seven", "C0013295#ent", "<e1>", "patients", "were", "treated", "for", "3", "months", "with", "C0008783#ent", "<e2>", "."], "h": {"id": "C0013295", "name": "C0013295#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [10, 11]}}
{"token": ["These", "data", "define", "C1540033#ent", "<e1>", "as", "a", "novel", "interaction", "partner", "of", "C2698447#ent", "<e2>", "and", "implicate", "cell-cell", "junctions", "the", "renal", "collecting", "duct", "the", "pathology", "of", "nephronophthisis", "."], "h": {"id": "C1540033", "name": "C1540033#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2698447", "name": "C2698447#ent", "pos": [11, 12]}}
{"token": ["This", "has", "been", "offset", ",", "however", ",", "by", "a", "fatal", "complacency", "stemming", "from", "previous", "successes", "such", "as", "the", "development", "of", "C0003207#ent", "<e1>", "the", "eradication", "of", "C0037354#ent", "<e2>", ",", "and", "global", "immunization", "programs"], "h": {"id": "C0003207", "name": "C0003207#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0037354", "name": "C0037354#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "the", "principle", "emerges", "that", "quantitative", "heterozygote", "tests", "for", "rare", "C3899988#ent", "<e1>", "not", "fulfill", "the", "C1416596#ent", "<e2>", "they", "were", "designed", "for", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [16, 17]}}
{"token": ["This", "patient", "represents", "a", "unique", "case", "of", "chronic", "cyclic", "urticaria", "and", "C3273421#ent", "<e1>", "that", "appears", "to", "be", "modulated", "by", "the", "effects", "of", "C2757070#ent", "<e2>", "."], "h": {"id": "C3273421", "name": "C3273421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [22, 23]}}
{"token": ["We", "confirmed", "interactions", "of", "the", "receptor", "with", "cAMP", "regulated", "C0120465#ent", "<e1>", "Epac1", ")", ",", "beta-spectrin", ",", "PIASy", ",", "and", "C1332803#ent", "<e2>", "immunoblotting", "."], "h": {"id": "C0120465", "name": "C0120465#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [19, 20]}}
{"token": ["Taken", "together", "our", "results", "suggest", "that", "several", "C1414564#ent", "<e1>", "isoforms", "are", "involved", "in", "C3888279#ent", "<e2>", "and", "that", "C1414564#ent", "<e1>", "genes", "are", "mostly", "expressed", "in", "relation", "to", "cell", "division", "enlargement", "."], "h": {"id": "C3888279", "name": "C3888279#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414564", "name": "C1414564#ent", "pos": [7, 8]}}
{"token": ["The", "IMT", "reflects", "diffuse", "early-phase", "C0004153#ent", "<e1>", ",", "whereas", "the", "angiographically", "determined", "C0242231#ent", "<e2>", "a", "late-phase", "phenomenon", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242231", "name": "C0242231#ent", "pos": [12, 13]}}
{"token": ["C1096458#ent", "<e1>", "BFO", ")", "as", "a", "regional", "therapy", "gemcitabine", "(", "C1334895#ent", "<e2>", ")", "was", "evaluated", "in", "a", "rat", "model", "."], "h": {"id": "C1096458", "name": "C1096458#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334895", "name": "C1334895#ent", "pos": [10, 11]}}
{"token": ["In", "the", "alpha-thalassemias", ",", "C1417679#ent", "<e1>", "encoding", "the", "C0544482#ent", "<e2>", "often", "deleted", ";", "abnormal", "transcription", "can", "also", "occur", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0544482", "name": "C0544482#ent", "pos": [8, 9]}}
{"token": ["The", "binding", "specificity", "C1823517#ent", "<e1>", "mAbs", "to", "nuclear", "and", "cytoplasmic", "antigens", "as", "C0010803#ent", "<e2>", ",", "actin", ",", "vimentin", ",", "and", "mitochondria", "was", "determined", "."], "h": {"id": "C1823517", "name": "C1823517#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [12, 13]}}
{"token": ["The", "FADD", "death", "domain", "binds", "to", "activated", "receptors", "such", "as", "Fas", "or", "other", "adapters", "such", "as", "C1336664#ent", "<e1>", ",", "whereas", "the", "C1333530#ent", "<e2>", "domain", "binds", "to", "procaspase", "8"], "h": {"id": "C1336664", "name": "C1336664#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333530", "name": "C1333530#ent", "pos": [21, 22]}}
{"token": ["The", "deglycosylated", "C0027203#ent", "<e1>", "more", "rapidly", "generated", "fibrinopeptide", "A", "native", "C0658380#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0658380", "name": "C0658380#ent", "pos": [10, 11]}}
{"token": ["C0025041#ent", "<e1>", "judged", "effective", "and", "safe", "in", "the", "treatment", "of", "C0949690#ent", "<e2>", "of", "the", "hip", "and", "knee", "."], "h": {"id": "C0025041", "name": "C0025041#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "the", "effect", "of", "inflammatory", "responses", "induced", "by", "intramuscular", "injection", "of", "turpentine", "on", "the", "C0234533#ent", "<e1>", "phenomenon", "in", "C1516876#ent", "<e2>", "C0234533#ent", "<e1>", "El", "mice"], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [19, 20]}}
{"token": ["C3160858#ent", "<e1>", "a", "treatable", "and", "reversible", "cause", "of", "C0085584#ent", "<e2>", "blindness", ",", "as", "long", "as", "an", "early", "diagnosis", "made", "."], "h": {"id": "C3160858", "name": "C3160858#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [8, 9]}}
{"token": ["Although", "C1420583#ent", "<e1>", "can", "maintain", "the", "nutritional", "and", "metabolic", "status", "a", "patient", "with", "C1412000#ent", "<e2>", "the", "associated", "risk", "catheter", "sepsis", "the", "necessity", "for", "expedient", "treatment", "of", "the", "primary", "pathology"], "h": {"id": "C1420583", "name": "C1420583#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412000", "name": "C1412000#ent", "pos": [13, 14]}}
{"token": ["The", "C0079429#ent", "<e1>", "belongs", "to", "the", "family", "of", "C0037207#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0037207", "name": "C0037207#ent", "pos": [8, 9]}}
{"token": ["Epithelial", "and", "C1384557#ent", "<e1>", "Etk", ")", ",", "also", "known", "as", "bone", "marrow", "X", "kinase", "C1332433#ent", "<e2>", ")", "plays", "an", "important", "role", "in", "the", "growth", ",", "differentiation", ",", "apoptosis", ",", "proliferation", ",", "and", "tumorigenicity", "of", "epithelial", "cells"], "h": {"id": "C1384557", "name": "C1384557#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332433", "name": "C1332433#ent", "pos": [14, 15]}}
{"token": ["A", "case", "of", "C0014121#ent", "<e1>", "Enterococcus", "faecalis", "colonoscopy", "in", "a", "patient", "with", "aortic", "stenoinsufficiency", "C0854242#ent", "<e2>", "Heyde's", "syndrome", "is", "reported", "."], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0854242", "name": "C0854242#ent", "pos": [14, 15]}}
{"token": ["We", "found", "no", "mutations", "in", "C1333543#ent", "<e1>", ",", "deletions", "of", "C0795832#ent", "<e2>", "9q", "or", "17p", ",", "MSI", "or", "MRP", "loss", ",", "or", "HPV", "positivity", "in", "any", "of", "the", "patients", "."], "h": {"id": "C1333543", "name": "C1333543#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0795832", "name": "C0795832#ent", "pos": [10, 11]}}
{"token": ["PET-derived", "estimates", "of", "MBF", "showed", "an", "abnormal", "C2827469#ent", "<e1>", "women", "with", "chest", "pain", "non-obstructive", "C0010068#ent", "<e2>", "and", "in", "women", "with", "high-risk", "conditions", "C0010068#ent", "<e2>", "."], "h": {"id": "C2827469", "name": "C2827469#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [14, 15]}}
{"token": ["The", "same", "sequence", "contains", "the", "cleavage", "site", "C0163582#ent", "<e1>", "residue", "248", ")", "previously", "shown", "to", "convert", "C1427631#ent", "<e2>", "into", "a", "nicked", "derivative", "which", "the", "two", "fragments", "still", "form", "a", "tight", "complex", "do", "n't", "display", "enzymatic", "activity"], "h": {"id": "C0163582", "name": "C0163582#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1427631", "name": "C1427631#ent", "pos": [16, 17]}}
{"token": ["Similar", "pathways", "likely", "operate", "in", "germ", "cells", "somatic", "cells", "with", "C1419310#ent", "<e1>", ",", "hnRNPGT", "and", "T-STAR", "proteins", "providing", "germ", "C1332691#ent", "<e2>", "components", "."], "h": {"id": "C1419310", "name": "C1419310#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [19, 20]}}
{"token": ["Thus", ",", "the", "HL-A", "haplotype", "segregation", "did", "not", "prove", "that", "a", "C0596707#ent", "<e1>", "related", "to", "the", "cause", "of", "C0026769#ent", "<e2>", "but", "study", "of", "additional", "multiplex", "families", "certainly", "warranted", "."], "h": {"id": "C0596707", "name": "C0596707#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [18, 19]}}
{"token": ["The", "effects", "of", "DHPA", "150", "mg", "+", "C3273628#ent", "<e1>", "10", "mg", "on", "HDL/LDL-cholesterol", "copper", ",", "ceruloplasmin", ",", "C1413150#ent", "<e2>", ",", "total", "and", "free", "cortisol", "SHBG", "were", "rare", "or", "non-existent", "."], "h": {"id": "C3273628", "name": "C3273628#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413150", "name": "C1413150#ent", "pos": [17, 18]}}
{"token": ["We", "have", "used", "a", "transgenic", "mouse", "line", "overexpressing", "the", "human", "C1417932#ent", "<e1>", "their", "neurons", "with", "C0669365#ent", "<e2>", "high", "putrescine", "to", "study", "the", "possible", "role", "of", "putrescine", "in", "development", "of", "neuronal", "damage", "forebrain", "ischaemia"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [15, 16]}}
{"token": ["Oxidative", "modifications", "also", "were", "not", "detected", "in", "sequences", "of", "the", "hypoxia", "down-regulated", "C1417932#ent", "<e1>", "TFAM", "genes", "or", "the", "C0669365#ent", "<e2>", "expressed", "beta-actin", "gene"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [18, 19]}}
{"token": ["The", "variations", "in", "levels", "of", "putrescine", "and", "arginine", "and", "C1417932#ent", "<e1>", "activities", "paralleled", "the", "C0669365#ent", "<e2>", "variation", "of", "antioxidant", "enzymes", "as", "well", "as", "oxidant", "resistance"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [14, 15]}}
{"token": ["Mutations", "in", "the", "C0021699#ent", "<e1>", "CRB1", "are", "associated", "with", "severe", "forms", "of", "retinal", "dystrophy", "C1838647#ent", "<e2>", "RP12", ")", ",", "and", "Leber's", "congenital", "amaurosis", "LCA", ")", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1838647", "name": "C1838647#ent", "pos": [14, 15]}}
{"token": ["This", "has", "lead", "to", "a", "number", "of", "significant", "advances", "including", "C2936526#ent", "<e1>", "the", "treatment", "of", "C0011991#ent", "<e2>", "5HT4", "agonists", "the", "treatment", "of", "constipation", "and", "5HT1", "agonists", "the", "treatment", "of", "impaired", "fundal", "relaxation", "."], "h": {"id": "C2936526", "name": "C2936526#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [15, 16]}}
{"token": ["This", "syndrome", "of", "adrenal", "insufficiency", "achalasia", ",", "alacrima", ",", "microcephaly", ",", "and", "C0235025#ent", "<e1>", "different", "from", "either", "adrenomyeloneuropathy", "or", "C0162309#ent", "<e2>", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0162309", "name": "C0162309#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", "to", "this", ",", "all", "C0018013#ent", "<e1>", "species", "investigated", "lacked", "C1417656#ent", "<e2>", "in", "cardiac", "muscles", "while", "it", "was", "present", "in", "the", "respective", "skeletal", "muscles"], "h": {"id": "C0018013", "name": "C0018013#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417656", "name": "C1417656#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "seven", "patients", "who", "developed", "a", "neurological", "syndrome", "the", "predominant", "manifestation", "of", "melioidosis", ":", "this", "C0039082#ent", "<e1>", "was", "characterized", "by", "peripheral", "motor", "weakness", "mimicking", "C0018378#ent", "<e2>", ",", "brain-stem", "encephalitis", ",", "aseptic", "meningitis", "and", "respiratory", "failure"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [25, 26]}}
{"token": ["The", "C1416809#ent", "<e1>", "resistant", "to", "C0041236#ent", "<e2>", "but", "was", "cleaved", "by", "chymotrypsin", "either", "in", "the", "presence", "or", "in", "the", "absence", "of", "poly(G", ")", ",", "indicating", "exposure", "of", "phenylalanines", "in", "this", "region", "."], "h": {"id": "C1416809", "name": "C1416809#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [5, 6]}}
{"token": ["However", ",", "the", "level", "and", "activity", "of", "cytochrome", "c", "oxidase", "decreased", "by", "about", "90", "%", ",", "whereas", "that", "of", "C0027293#ent", "<e1>", "cytochrome", "c", "reductase", "unchanged", "as", "compared", "with", "the", "C2987364#ent", "<e2>", "enzymes", "."], "h": {"id": "C0027293", "name": "C0027293#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [29, 30]}}
{"token": ["Antibacterials", "penetrate", "less", "into", "the", "C1420388#ent", "<e1>", "than", "into", "the", "bronchial", "mucosa", "but", "C0949665#ent", "<e2>", "appear", "to", "concentrate", "more", "into", "alveolar", "lavage", "into", "bronchial", "mucosa"], "h": {"id": "C1420388", "name": "C1420388#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0949665", "name": "C0949665#ent", "pos": [13, 14]}}
{"token": ["One", "of", "the", "pleiotropic", "activators", "of", "C0017347#ent", "<e1>", "Drosophila", ",", "the", "C1705665#ent", "<e2>", "encodes", "a", "protein", "similar", "to", "a", "yeast", "protein", "is", "required", "for", "transcriptional", "activation", "multiple", "tightly", "regulated", "genes", "."], "h": {"id": "C0017347", "name": "C0017347#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705665", "name": "C1705665#ent", "pos": [11, 12]}}
{"token": ["To", "compare", "the", "effects", "of", "C0009905#ent", "<e1>", "combination", "with", "C0770893#ent", "<e2>", "on", "the", "clinical", ",", "endocrine", "and", "metabolic", "parameters", "in", "obese", "and", "non-obese", "patients", "with", "PCOS", "."], "h": {"id": "C0009905", "name": "C0009905#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [9, 10]}}
{"token": ["Patients", "were", "treated", "with", "weight-stabilization", "and", "-reduction", "program", ",", "C0009905#ent", "<e1>", "and", "in", "most", "cases", "C0770893#ent", "<e2>", "."], "h": {"id": "C0009905", "name": "C0009905#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [15, 16]}}
{"token": ["The", "biochemical", "aspects", "human", "C0151747#ent", "<e1>", "analysed", "by", "in", "vitro", "culture", "in", "the", "presence", "of", "C0733397#ent", "<e2>", "NDGA", ")", "."], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0733397", "name": "C0733397#ent", "pos": [15, 16]}}
{"token": ["These", "include", "fatal", "familial", "insomnia", "with", "involvement", "of", "the", "C0033164#ent", "<e1>", "chromosome", "20", "Norrie", "disease", "the", "Prader-Willi", "syndrome", "the", "C0221060#ent", "<e2>"], "h": {"id": "C0033164", "name": "C0033164#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0221060", "name": "C0221060#ent", "pos": [19, 20]}}
{"token": ["These", "results", "suggest", "that", "the", "transcript", "levels", "of", "C1865361#ent", "<e1>", "are", "co-regulated", "with", "those", "of", "C0070788#ent", "<e2>", "and", "CMO", "to", "supply", "SAM", "for", "betaine", "synthesis", "in", "the", "leaves", "."], "h": {"id": "C1865361", "name": "C1865361#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0070788", "name": "C0070788#ent", "pos": [15, 16]}}
{"token": ["C2239904#ent", "<e1>", "conductances", "were", "higher", "and", "C0029899#ent", "<e2>", "shorter", "when", "compared", "to", "LVH", "."], "h": {"id": "C2239904", "name": "C2239904#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029899", "name": "C0029899#ent", "pos": [6, 7]}}
{"token": ["Immunoprecipitation", "of", "C0031727#ent", "<e1>", "associated", "with", "BCR", "and", "CD21/CD19/CD81", "complexes", "demonstrated", "that", "C1442804#ent", "<e2>", "is", "preferentially", "depleted", "from", "the", "BCR", "complex", "following", "excess", "binding", "of", "CD21", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1442804", "name": "C1442804#ent", "pos": [12, 13]}}
{"token": ["It", "may", "be", "useful", "in", "differential", "diagnosis", "as", "an", "objective", "means", "of", "monitoring", "therapy", "progress", "in", "conditions", "such", "as", "C0235946#ent", "<e1>", "hydrocephalus", ",", "and", "benign", "C0151740#ent", "<e2>"], "h": {"id": "C0235946", "name": "C0235946#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0151740", "name": "C0151740#ent", "pos": [25, 26]}}
{"token": ["Previous", "studies", "have", "shown", "that", "nefazodone", "is", "a", "potent", "antagonist", "of", "C1708300#ent", "<e1>", "binds", "to", "the", "C1420214#ent", "<e2>", "in", "vitro", "in", "vivo"], "h": {"id": "C1708300", "name": "C1708300#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420214", "name": "C1420214#ent", "pos": [16, 17]}}
{"token": ["77", "patients", "with", "serious", "resistant", "C0038160#ent", "<e1>", "including", "septicemia", ",", "C0149725#ent", "<e2>", "intraabdominal", "infection", "skin", "and", "soft", "tissue", "infections", "urinary", "tract", "infection", "were", "treated", "with", "."], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149725", "name": "C0149725#ent", "pos": [10, 11]}}
{"token": ["Sanguinarine", "appears", "to", "be", "the", "most", "effective", "inhibitor", "of", "C4082365#ent", "<e1>", "IC50", "284", "nM", ")", ",", "while", "the", "C0005117#ent", "<e2>", "were", "inactive", "at", "this", "target", "."], "h": {"id": "C4082365", "name": "C4082365#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0005117", "name": "C0005117#ent", "pos": [18, 19]}}
{"token": ["Escherichia", "coli", "TAP", "C0087079#ent", "<e1>", "EC", "3.1.2.2", ")", "is", "a", "C3658346#ent", "<e2>", "thioesterase", ",", "esterase", ",", "arylesterase", ",", "protease", "and", "lysophospholipase", "activities"], "h": {"id": "C0087079", "name": "C0087079#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3658346", "name": "C3658346#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "the", "effect", "of", "C0389573#ent", "<e1>", "on", "human", "keratinocyte", "(", "C0022575#ent", "<e2>", ")", "production", "of", "interferon-alpha", "(", "IFN-alpha", ")", "and", "other", "proinflammatory", "cytokines", "including", "interleukin", "(IL)-1alpha", "IL-8", ",", "and", "tumor", "necrosis", "factor-alpha", "TNF-alpha", ")", "."], "h": {"id": "C0389573", "name": "C0389573#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022575", "name": "C0022575#ent", "pos": [11, 12]}}
{"token": ["The", "dissection", "of", "the", "papilla", "was", "carried", "out", "in", "70", "patients", "with", "pure", "C0030353#ent", "<e1>", "with", "papillitis", "combined", "with", "choledocholithiasis", "and", "C0267917#ent", "<e2>", "."], "h": {"id": "C0030353", "name": "C0030353#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0267917", "name": "C0267917#ent", "pos": [21, 22]}}
{"token": ["Virulent", "strains", "Yersinia", "enterocolitica", "disease", "syndromes", "from", "C0152517#ent", "<e1>", "lymphadenitis", "and", "C0036690#ent", "<e2>", "."], "h": {"id": "C0152517", "name": "C0152517#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [11, 12]}}
{"token": ["Spinocerebellar", "ataxia", "type", "2", "SCA2", ")", "is", "a", "member", "of", "a", "group", "of", "C0751870#ent", "<e1>", "are", "caused", "by", "instability", "of", "a", "C3275238#ent", "<e2>"], "h": {"id": "C0751870", "name": "C0751870#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3275238", "name": "C3275238#ent", "pos": [21, 22]}}
{"token": ["To", "investigate", "the", "efficacy", "of", "the", "cholesterol", "absorption", "C1142985#ent", "<e1>", "in", "patients", "with", "refractory", "C0020474#ent", "<e2>", "intolerant", "to", "statin", "therapy"], "h": {"id": "C1142985", "name": "C1142985#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0020474", "name": "C0020474#ent", "pos": [14, 15]}}
{"token": ["Considering", "these", "results", ",", "it", "does", "not", "appear", "that", "C0015967#ent", "<e1>", "neutropenia", "is", "reduced", "by", "C0008809#ent", "<e2>", "during", "grade", "IV", "neutropenia"], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [15, 16]}}
{"token": ["Adequate", "tissue", "perfusion", "important", "and", "can", "be", "achieved", "by", "controlling", "C0002932#ent", "<e1>", "increasing", "intravascular", "volume", "fluid", "administration", "and", "by", "administering", "C0030512#ent", "<e2>"], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030512", "name": "C0030512#ent", "pos": [20, 21]}}
{"token": ["Cardiopathy", "did", "not", "antedate", "C0026848#ent", "<e1>", "patients", "had", "no", "symptoms", "of", "C0878544#ent", "<e2>", "until", "a", "late", "phase", "the", "disease", "."], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0878544", "name": "C0878544#ent", "pos": [11, 12]}}
{"token": ["Methysergide", "and", "C0025654#ent", "<e1>", ",", "mixed", "5-HT1/2", "antagonists", "as", "well", "as", "ondansetron", ",", "a", "C0360055#ent", "<e2>", "showed", "an", "intrinsic", "effect", "ACh", "release", ",", "their", "effects", "being", "additive", "to", "that", "of", "SKF", "38393", "."], "h": {"id": "C0025654", "name": "C0025654#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0360055", "name": "C0360055#ent", "pos": [14, 15]}}
{"token": ["C1572795#ent", "<e1>", "prevented", "IkB-alpha", "degradation", "and", "C2986464#ent", "<e2>", "confirming", "the", "involvement", "of", "this", "transcriptional", "factor", "the", "control", "of", "peripheral", "inflammation"], "h": {"id": "C1572795", "name": "C1572795#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [6, 7]}}
{"token": ["We", "compared", "the", "results", "of", "cystometry", "and", "urethral", "profilometry", "with", "and", "without", "C0237406#ent", "<e1>", "(", "and", "L", "dopa", "in", "12", "idiopathic", "parkinsonians", "C0042075#ent", "<e2>", "dopaminergic", "treatment"], "h": {"id": "C0237406", "name": "C0237406#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [22, 23]}}
{"token": ["It", "has", "been", "suggested", "that", "chronically", "reduced", "myocardial", "adenosine", "triphosphate", "C2744579#ent", "<e1>", ")", "content", "causes", "C0543968#ent", "<e2>", "dilated", "cardiomyopathy"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0543968", "name": "C0543968#ent", "pos": [15, 16]}}
{"token": ["The", "present", "results", "suggest", "that", "the", "bombesin-induced", "increases", "in", "plasma", "levels", "of", "catecholamines", "are", "probably", "due", "to", "C0033568#ent", "<e1>", "the", "brain", "with", "this", "C1334960#ent", "<e2>", "."], "h": {"id": "C0033568", "name": "C0033568#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1334960", "name": "C1334960#ent", "pos": [23, 24]}}
{"token": ["The", "results", "of", "these", "immunoneutralization", "studies", "suggest", "that", "endogenous", "C1417807#ent", "<e1>", "does", "not", "play", "a", "role", "in", "C1336679#ent", "<e2>", "release", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1336679", "name": "C1336679#ent", "pos": [17, 18]}}
{"token": ["Conversion", "of", "testosterone", "(", "T", ")", "to", "dihydrotestosterone", "(", "DHT", ")", "in", "genital", "tissue", "catalysed", "by", "the", "C0039602#ent", "<e1>", "which", "is", "encoded", "by", "the", "C0919429#ent", "<e2>"], "h": {"id": "C0039602", "name": "C0039602#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0919429", "name": "C0919429#ent", "pos": [24, 25]}}
{"token": ["Mutations", "in", "the", "protein", "O-mannose", "beta-1", ",", "2-N-acetylglucosaminyltransferase", "(", "POMGnT-1", ")", "and", "C0219164#ent", "<e1>", "2", "(", "POMT1", "and", "POMT2", ")", "genes", "cause", "C0457133#ent", "<e2>", "Walker-Warburg", "syndrome", "respectively", "."], "h": {"id": "C0219164", "name": "C0219164#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0457133", "name": "C0457133#ent", "pos": [22, 23]}}
{"token": ["While", "C0010525#ent", "<e1>", "is", "widely", "used", "in", "the", "therapy", "of", "C0085096#ent", "<e2>", "objective", "evidence", "of", "its", "efficacy", "remains", "controversial", "."], "h": {"id": "C0010525", "name": "C0010525#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "in", "NIH", "3T3", "NG108", "cells", "endogenous", "C1706479#ent", "<e1>", "is", "phosphorylated", "specifically", "by", "EphB3", "and", "C1705767#ent", "<e2>", "in", "a", "ligand-dependent", "fashion", "."], "h": {"id": "C1706479", "name": "C1706479#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705767", "name": "C1705767#ent", "pos": [16, 17]}}
{"token": ["Measurements", "of", "plasma", "IGFBP-1", ",", "IGFBP-2", ",", "and", "C1334095#ent", "<e1>", "revealed", "no", "significant", "changes", "in", "response", "to", "C0038880#ent", "<e2>", "."], "h": {"id": "C1334095", "name": "C1334095#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [17, 18]}}
{"token": ["A", "polypeptide", "tag", "the", "N-terminus", "is", "selectively", "cleaved", "from", "the", "C0035334#ent", "<e1>", "after", "limited", "C0041236#ent", "<e2>", "digestion", "in", "further", "support", "of", "a", "compact", "folded", "structure"], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "demonstrates", "that", "C0073716#ent", "<e1>", "induces", "QR", "activity", "and", "gene", "expression", "transactivation", "of", "C0087140#ent", "<e2>", "."], "h": {"id": "C0073716", "name": "C0073716#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [15, 16]}}
{"token": ["Still", "defying", "understanding", "are", "the", "roles", "of", "C0003940#ent", "<e1>", "acting", "on", "adenosine", "5'-phosphosulphate", "C1427290#ent", "<e2>", ")", "and", "3'-phosphoadenosine", "5'-phosphosulphate", "PAPA", ")", "."], "h": {"id": "C0003940", "name": "C0003940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1427290", "name": "C1427290#ent", "pos": [13, 14]}}
{"token": ["No", "C1416669#ent", "<e1>", "activity", "is", "generated", "in", "factor", "XII", "C0313532#ent", "<e2>", "only", "small", "amounts", "8", "%", ")", "in", "high", "molecular", "weight", "HMW", ")", "kininogen-deficient", "plasma", "."], "h": {"id": "C1416669", "name": "C1416669#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0313532", "name": "C0313532#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "prolonged", "infusion", "of", "C0070426#ent", "<e1>", "(", "1", "mg/kg/d", ")", "were", "studied", "on", "C2745953#ent", "<e2>", "rats", "and", "spontaneously", "hypertensive", "SHR", "rats", "compared", "to", "control", "animals"], "h": {"id": "C0070426", "name": "C0070426#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2745953", "name": "C2745953#ent", "pos": [15, 16]}}
{"token": ["Quantitative", "analyses", "that", "C1366463#ent", "<e1>", "increased", "the", "adipocyte", "differentiation", "induced", "by", "the", "peroxisome", "proliferator-activated", "receptor", "gamma", "agonist", "BRL49653", "C1412820#ent", "<e2>", ")", "in", "RC", "cell", "."], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412820", "name": "C1412820#ent", "pos": [18, 19]}}
{"token": ["S-SI", ",", "plasminostreptin", ",", "elastatinal", ",", "antipain", "and", "C0035100#ent", "<e1>", ",", "which", "are", "inhibitors", "for", "C0030940#ent", "<e2>", "partly", "but", "significantly", "inhibited", "ovulation", "."], "h": {"id": "C0035100", "name": "C0035100#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [15, 16]}}
{"token": ["WISH", "cells", "treated", "with", "C0085536#ent", "<e1>", "vanadate/", "H2O2", ",", "resulted", "in", "increased", "levels", "of", "C2346918#ent", "<e2>", "secretion", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2346918", "name": "C2346918#ent", "pos": [14, 15]}}
{"token": ["Consistent", "with", "C3537142#ent", "<e1>", "potency", "in", "vitro", "intra-cutaneous", "5-hydroxypropafenone", "had", "a", "smaller", "local", "C0002932#ent", "<e2>", "the", "guinea", "pig", "wheal", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002932", "name": "C0002932#ent", "pos": [13, 14]}}
{"token": ["In", "this", "simplified", "model", "for", "gene", "activation", "C0733688#ent", "<e1>", "recruits", "the", "general", "factors", "and", "the", "cofactors", "Mediator", "C1705589#ent", "<e2>", ",", "CBP", ",", "and", "PC4", ",", "within", "minutes", "to", "the", "promoter", "region"], "h": {"id": "C0733688", "name": "C0733688#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705589", "name": "C1705589#ent", "pos": [17, 18]}}
{"token": ["Carbamazepine", ",", "phenytoin", ",", "gabapentin", ",", "C0060135#ent", "<e1>", "and", "lamotrigine", "inhibited", "only", "C0270844#ent", "<e2>", "mortality", "."], "h": {"id": "C0060135", "name": "C0060135#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0270844", "name": "C0270844#ent", "pos": [12, 13]}}
{"token": ["The", "requirement", "for", "C0035679#ent", "<e1>", "to", "prevent", "oncogene-induced", "apoptosis", "implies", "the", "need", "for", "the", "C0907533#ent", "<e2>", "expression", "of", "an", "antiapoptotic", "gene(s", ")", "to", "maintain", "the", "transformed", "state"], "h": {"id": "C0035679", "name": "C0035679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}}
{"token": ["The", "efficacy", "of", "terbinafine", "in", "the", "treatment", "of", "C0040261#ent", "<e1>", "and", "other", "C0037274#ent", "<e2>", "is", "reviewed", "."], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [12, 13]}}
{"token": ["This", "inhibitory", "effect", "of", "the", "venom", "was", "significantly", "reduced", "by", "prior", "incubation", "of", "the", "venom", "with", "C0065711#ent", "<e1>", "(", "1", "microM", ")", "indicating", "involvement", "of", "a", "C1744607#ent", "<e2>", "."], "h": {"id": "C0065711", "name": "C0065711#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1744607", "name": "C1744607#ent", "pos": [26, 27]}}
{"token": ["The", "genes", "C1415617#ent", "<e1>", ",", "FDPS", ",", "RAFTLIN", ",", "C1412106#ent", "<e2>", ",", "NPC2", ",", "and", "ABCG1", "were", "associated", "with", "AD", "at", "a", "significance", "level", "P", "<", "or", "=", "0.05", "in", "this", "sample", "."], "h": {"id": "C1415617", "name": "C1415617#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412106", "name": "C1412106#ent", "pos": [9, 10]}}
{"token": ["Two", "haplotypes", "were", "frequently", "associated", "with", "C0011854#ent", "<e1>", "patients", "in", "whom", "the", "C4A", "and", "C1413000#ent", "<e2>", "were", "deleted", "genes"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413000", "name": "C1413000#ent", "pos": [14, 15]}}
{"token": ["C0038463#ent", "<e1>", "is", "an", "intestinal", "C0747256#ent", "<e2>", "by", "Strongyloides", "stercoralis"], "h": {"id": "C0038463", "name": "C0038463#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [5, 6]}}
{"token": ["A", "comparison", "of", "total", "cellular", "protein", "early", "passage", "and", "proliferatively", "aged", "fibroblasts", "identified", "an", "altered", "form", "of", "the", "C0164005#ent", "<e1>", "senescent", "cells", "a", "result", "that", "could", "explain", "the", "increase", "in", "C1956096#ent", "<e2>", "these", "cells", "."], "h": {"id": "C0164005", "name": "C0164005#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1956096", "name": "C1956096#ent", "pos": [30, 31]}}
{"token": ["Cultured", "cardiac", "myocytes", "stained", "with", "antibodies", "to", "sarcomeric", "alpha-actinin", ",", "troponin-I", ",", "alpha-actin", ",", "C3815884#ent", "<e1>", "MHC", ")", ",", "titin", ",", "C1417576#ent", "<e2>", ",", "C-protein", ",", "and", "vinculin", "."], "h": {"id": "C3815884", "name": "C3815884#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417576", "name": "C1417576#ent", "pos": [21, 22]}}
{"token": ["In", "the", "case-history", "we", "must", "always", "focus", "attention", "on", "risk", "factors", "associated", "with", "C0015732#ent", "<e1>", "and", "questions", "on", "the", "abuse", "of", "C0001962#ent", "<e2>", "are", "also", "justified", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [21, 22]}}
{"token": ["Affinity-purified", "C1826761#ent", "<e1>", "also", "contained", "the", "previously", "identified", "p25", "and", "C1424876#ent", "<e2>", "as", "well", "as", "a", "Mr", "32,000", "peptide", "(", "p32", ")", "."], "h": {"id": "C1826761", "name": "C1826761#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1424876", "name": "C1424876#ent", "pos": [10, 11]}}
{"token": ["Such", "upregulated", "C0017337#ent", "<e1>", "included", "those", "involved", "in", "nuclear", "structure", "meiosis", "(", "C1420540#ent", "<e2>", ")", ",", "DNA", "repair", "RFC5", ")", ",", "and", "transcription", "regulation", "ZNF238", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420540", "name": "C1420540#ent", "pos": [12, 13]}}
{"token": ["Lipid-related", "oxidative", "stress", ",", "such", "as", "that", "caused", "by", "malondialdehyde", "(", "MDA", ")", ",", "acrolein", ",", "and", "C0048297#ent", "<e1>", "(", "4-HNE", ")", ",", "is", "involved", "in", "vascular", "injury", "C0011847#ent", "<e2>", "and", "hypertension", "."], "h": {"id": "C0048297", "name": "C0048297#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [28, 29]}}
{"token": ["To", "observe", "the", "protective", "effect", "the", "intercellular", "communication", "retinal", "pigment", "epithelial", "RPE", ")", "cells", "of", "C0011777#ent", "<e1>", "(", "Dex", ")", "and", "C0042523#ent", "<e2>", "(", "Ver", ")", "at", "different", "concentrations", "after", "laser", "photocoagulation"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [21, 22]}}
{"token": ["Other", "adhesion", "receptors", "members", "of", "the", "VLA", "subclass", "of", "the", "integrin", "family", "VLA-2", ",", "C1704700#ent", "<e1>", "and", "VLA-6", ",", "which", "mediate", "platelet", "adhesion", "C0009325#ent", "<e2>", ",", "fibronectin", "and", "laminin", ",", "respectively", "."], "h": {"id": "C1704700", "name": "C1704700#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [23, 24]}}
{"token": ["While", "the", "contents", "of", "TL", ",", "TG", "and", "ChE", "in", "the", "C0023899#ent", "<e1>", "of", "the", "deficient", "rats", "increased", "significantly", ",", "those", "of", "C1705270#ent", "<e2>", "and", "Ch", "were", "hardly", "affected", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705270", "name": "C1705270#ent", "pos": [22, 23]}}
{"token": ["Children", "with", "severe", "reflux", "and", "C0014863#ent", "<e1>", "have", "a", "loose", "C0120465#ent", "<e2>", "performed", "."], "h": {"id": "C0014863", "name": "C0014863#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [10, 11]}}
{"token": ["Only", "four", "C0017337#ent", "<e1>", "were", "discovered", "in", "this", "interval", ",", "namely", ",", "C1824131#ent", "<e2>", ",", "ITGA9", ",", "HYA22", "and", "VILL", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1824131", "name": "C1824131#ent", "pos": [12, 13]}}
{"token": ["C0221056#ent", "<e1>", ",", "polymyositis", ",", "inclusion", "body", "myositis", "myositis", "overlap", "syndromes", "are", "C1334156#ent", "<e2>", "unknown", "origin", "with", "muscle", "weakness", "elevated", "values", "of", "creatinkinase", "in", "the", "serum", "."], "h": {"id": "C0221056", "name": "C0221056#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334156", "name": "C1334156#ent", "pos": [12, 13]}}
{"token": ["The", "hemodynamic", "and", "clinical", "effects", "parenteral", "and", "oral", "C1615605#ent", "<e1>", ",", "a", "new", "phosphodiesterase", "type", "III", "inhibitor", "combined", "C0042402#ent", "<e2>", "and", "inotropic", "properties", "were", "studied", "in", "12", "patients", "with", "severe", "congestive", "heart", "failure", "to", "therapy", "including", "captopril", "."], "h": {"id": "C1615605", "name": "C1615605#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [18, 19]}}
{"token": ["The", "crucial", "role", "of", "the", "human", "C1416498#ent", "<e1>", "maintaining", "normal", "hemostasis", "is", "best", "exemplified", "by", "the", "C0040015#ent", "<e2>", "GT", ")", "."], "h": {"id": "C1416498", "name": "C1416498#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0040015", "name": "C0040015#ent", "pos": [16, 17]}}
{"token": ["We", "describe", "here", "a", "woman", "in", "whom", "marked", "peripheral", "eosinophilia", "liver", "disease", "and", "systemic", "vasculitis", "while", "taking", "C0086073#ent", "<e1>", "and", "resolved", "or", "improved", "on", "discontinuation", "of", "the", "C0013227#ent", "<e2>", "and", "treatment", "with", "corticosteroids", "."], "h": {"id": "C0086073", "name": "C0086073#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [27, 28]}}
{"token": ["Six", "(", "Importin-7", ",", "MGC10471", ",", "FOXC1", ",", "subunit", "p20", "Arp2/3", "complex", "mitochondrial", "ribosomal", "protein", "L32", "and", "the", "serine/threonine", "kinase-4", "C3274759#ent", "<e1>", ")", ")", "of", "these", "C0017337#ent", "<e2>", "were", "confirmed", "by", "quantitative", "real", "time", "PCR"], "h": {"id": "C3274759", "name": "C3274759#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [26, 27]}}
{"token": ["LPB5", ",", "a", "common", "C1706112#ent", "<e1>", "associated", "with", "reduced", "low", "density", "clearance", "and", "C0020445#ent", "<e2>", "in", "pigs", ",", "is", "identified", "by", "a", "283-bp", "insertion", "in", "intron", "28", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [13, 14]}}
{"token": ["These", "findings", "suggest", "that", "EPO", "may", "provide", "benefit", "after", "C0752304#ent", "<e1>", "the", "developing", "brain", ",", "a", "major", "contributor", "to", "C0085584#ent", "<e2>", "cerebral", "palsy"], "h": {"id": "C0752304", "name": "C0752304#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [19, 20]}}
{"token": ["Over", "expression", "of", "C0376515#ent", "<e1>", "blocked", "TRAIL-induced", "apoptosis", "in", "the", "presence", "of", "C0755562#ent", "<e2>", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "C1334887#ent", "<e1>", ",", "acting", "via", "the", "C1366488#ent", "<e2>", "CRH", ")", "system", ",", "induces", "gross", "locomotor", "activity", "stress", "responses"], "h": {"id": "C1334887", "name": "C1334887#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366488", "name": "C1366488#ent", "pos": [9, 10]}}
{"token": ["A", "patient", "with", "cancer", "of", "unknown", "primary", "site", "suffering", "from", "diffuse", "bone", "marrow", "metastasis", "C1420151#ent", "<e1>", ",", "was", "treated", "with", "FAM", "(", "5-fluorouracil", ",", "C0014582#ent", "<e2>", "and", "mitomycin", "C", "combination", "chemotherapy"], "h": {"id": "C1420151", "name": "C1420151#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014582", "name": "C0014582#ent", "pos": [24, 25]}}
{"token": ["We", "describe", "a", "case", "of", "a", "premature", "neonate", "developed", "C0235591#ent", "<e1>", "a", "hypervirulent", "strain", "of", "C0343401#ent", "<e2>"], "h": {"id": "C0235591", "name": "C0235591#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0343401", "name": "C0343401#ent", "pos": [15, 16]}}
{"token": ["When", "neurons", "are", "incubated", "with", "3-OH", "glutarate", "-", "a", "substance", "accumulating", "in", "C0268594#ent", "<e1>", "a", "model", "for", "C0268595#ent", "<e2>", "ATP-synthase", "activity", "compromised", "."], "h": {"id": "C0268594", "name": "C0268594#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0268595", "name": "C0268595#ent", "pos": [17, 18]}}
{"token": ["XRCC1", "functions", "as", "a", "scaffold", "protein", "interacting", "and", "modulating", "polypeptide", "components", "the", "single-strand", "break", "repair", "machinery", "including", "AP", "endonuclease-1", "C1565517#ent", "<e1>", "poly", "(", "ADP-ribose", ")", "polymerase", ",", "DNA", "polymerase", "beta", "human", "C1418707#ent", "<e2>"], "h": {"id": "C1565517", "name": "C1565517#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1418707", "name": "C1418707#ent", "pos": [31, 32]}}
{"token": ["Lower", "respiratory", "infection", "disease", "considered", "to", "include", "the", "following", "entities", ":", "acute", "lower", "respiratory", "infections", ",", "pneumonia", ",", "C1412002#ent", "<e1>", "bronchitis", ",", "and", "C0006271#ent", "<e2>", "."], "h": {"id": "C1412002", "name": "C1412002#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0006271", "name": "C0006271#ent", "pos": [23, 24]}}
{"token": ["The", "effects", "of", "glycyrrhizin", "on", "the", "rate", "of", "metabolism", "of", "cortisol", "as", "well", "as", "C0032950#ent", "<e1>", "were", "studied", "in", "23", "patients", "with", "or", "without", "C0001623#ent", "<e2>"], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0001623", "name": "C0001623#ent", "pos": [24, 25]}}
{"token": ["High", "doses", "C3540725#ent", "<e1>", "improved", "the", "skin", "condition", "failed", "to", "prevent", "the", "C0442874#ent", "<e2>", "."], "h": {"id": "C3540725", "name": "C3540725#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [12, 13]}}
{"token": ["To", "establish", "if", "the", "C3536880#ent", "<e1>", "patients", "with", "C1561643#ent", "<e2>", "significantly", "and", "with", "security", "the", "levels", "of", "lipids", "and", "serum", "phosphate", "refractory", "patients", "to", "the", "classical", "management"], "h": {"id": "C3536880", "name": "C3536880#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [8, 9]}}
{"token": ["The", "DOXP/MEP", "pathway", "leads", "to", "the", "formation", "of", "various", "phosphorylated", "intermediates", ",", "including", "DOXP", ",", "4-hydroxy-3-methylbutenyl", "diphosphate", "C1417057#ent", "<e1>", ")", ",", "and", "finally", "C0020823#ent", "<e2>", "."], "h": {"id": "C1417057", "name": "C1417057#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [23, 24]}}
{"token": ["The", "incidence", "of", "C0010054#ent", "<e1>", "detected", "by", "Holter", "monitor", "36", "%", "with", "C0002697#ent", "<e2>", "and", "33", "%", "with", "dobutamine", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002697", "name": "C0002697#ent", "pos": [12, 13]}}
{"token": ["The", "authors", "present", "a", "case", "of", "C0041312#ent", "<e1>", "affecting", "exclusively", "the", "left", "colon", "severe", "C0162429#ent", "<e2>", ",", "abdominal", "pain", "and", "bowel", "obstruction", "a", "sealed", "colonic", "fistula", "a", "10-year-old", "child", "."], "h": {"id": "C0041312", "name": "C0041312#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [14, 15]}}
{"token": ["Severe", "C0024535#ent", "<e1>", "malaria", "is", "one", "of", "the", "most", "lethal", "C0747256#ent", "<e2>", "the", "world", "and", "is", "responsible", "for", "more", "than", "one", "million", "deaths", "in", "African", "children", "per", "year", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [10, 11]}}
{"token": ["Positional", "cloning", "six", "novel", "genes", "(", "C1417782#ent", "<e1>", "through", "6", ")", "as", "mutated", "in", "C3539770#ent", "<e2>", "and", "functional", "characterization", "of", "their", "encoded", "proteins", "have", "contributed", "to", "the", "concept", "of", "\"", "ciliopathies", "."], "h": {"id": "C1417782", "name": "C1417782#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539770", "name": "C3539770#ent", "pos": [14, 15]}}
{"token": ["IL-1beta", "and", "TNF-alpha", "strongly", "stimulated", "IL-6-type", "cytokine", "release", "(", "except", "for", "C0279238#ent", "<e1>", ")", "by", "both", "C2986870#ent", "<e2>", "and", "BMSC", "."], "h": {"id": "C0279238", "name": "C0279238#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2986870", "name": "C2986870#ent", "pos": [16, 17]}}
{"token": ["These", "findings", "confirm", "the", "heavy", "burden", "C0041466#ent", "<e1>", "pneumonia", "in", "Kathmandu", ",", "and", "highlight", "the", "importance", "of", "C0041472#ent", "<e2>", "scrub", "typhus", "and", "leptospirosis", "."], "h": {"id": "C0041466", "name": "C0041466#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041472", "name": "C0041472#ent", "pos": [17, 18]}}
{"token": ["The", "high", "substrate", "specificity", "of", "human", "C4085186#ent", "<e1>", "Ang", "I", "it", "from", "other", "Ang", "II-forming", "enzymes", "including", "Ang", "I", "C0014442#ent", "<e2>", ",", "tonin", ",", "kallikrein", ",", "cathepsin", "G", "and", "other", "known", "chymases", "."], "h": {"id": "C4085186", "name": "C4085186#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [19, 20]}}
{"token": ["This", "report", "concerns", "two", "patients", "with", "C0004775#ent", "<e1>", "were", "treated", "with", "propranolol", ",", "C0037982#ent", "<e2>", ",", "and", "potassium", "supplements"], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037982", "name": "C0037982#ent", "pos": [13, 14]}}
{"token": ["Rodents", "immunized", "with", "complete", "C0281643#ent", "<e1>", "CFA", ")", "are", "resistant", "to", "subsequent", "attempts", "to", "induce", "C0004364#ent", "<e2>", "while", "animals", "immunized", "with", "incomplete", "C0281643#ent", "<e1>", "IFA", ")", "remain", "susceptible", "."], "h": {"id": "C0281643", "name": "C0281643#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [15, 16]}}
{"token": ["Replication", "factor", "C", "RFC", ",", "also", "called", "C1419349#ent", "<e1>", ",", "in", "conjunction", "with", "C1366837#ent", "<e2>", "PCNA", ")", ",", "is", "responsible", "for", "processive", "DNA", "synthesis", "catalyzed", "by", "the", "eukaryotic", "replicative", "DNA", "polymerases", "delta", "and", "epsilon", "."], "h": {"id": "C1419349", "name": "C1419349#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [13, 14]}}
{"token": ["C0206157#ent", "<e1>", ",", "neuropathy", "and", "C0265213#ent", "<e2>", "essentially", "revealed", "group", "1", "patterns", ",", "whereas", "idiopathic", "toe-walkers", "mainly", "displayed", "group", "2", "patterns", "."], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0265213", "name": "C0265213#ent", "pos": [5, 6]}}
{"token": ["It", "has", "been", "proposed", "that", "C3814866#ent", "<e1>", "sequences", "containing", "homology", "to", "C0019611#ent", "<e2>", "HisRS", ")", "bind", "uncharged", "tRNA", "that", "accumulate", "during", "amino", "acid", "and", "stimulate", "the", "activity", "of", "GCN2", "kinase", "."], "h": {"id": "C3814866", "name": "C3814866#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019611", "name": "C0019611#ent", "pos": [11, 12]}}
{"token": ["Similarly", ",", "araC-resistant", "cells", ",", "normally", "unable", "to", "die", "in", "response", "to", "C0060103#ent", "<e1>", ",", "initiated", "apoptosis", "when", "electroporated", "with", "active", "C1335240#ent", "<e2>", "."], "h": {"id": "C0060103", "name": "C0060103#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335240", "name": "C1335240#ent", "pos": [21, 22]}}
{"token": ["Wilson's", "Disease", "be", "excluded", "in", "children", "presenting", "with", "frank", "liver", "disease", "well", "as", "those", "with", "C1387532#ent", "<e1>", "persisting", "lethargy", ",", "C0000737#ent", "<e2>", "or", "deteriorating", "school", "performance"], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [20, 21]}}
{"token": ["This", "organism", "contains", "the", "enzyme", "C0244989#ent", "<e1>", "and", "a", "beta", "-catenin", "C1334043#ent", "<e2>", ",", "Aardvark", "(", "Aar", ")", "."], "h": {"id": "C0244989", "name": "C0244989#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}}
{"token": ["As", "shown", "by", "31P", "and", "proton", "NMR", "perchloric", "extracts", ",", "the", "chemical", "shift", "some", "of", "the", "compounds", "was", "characteristic", "of", "glycerophosphorylcholine", ",", "glycerophosphorylinositol", ",", "C0031716#ent", "<e1>", ",", "phosphorylserine", ",", "phosphorylethanolamine", "and", "C0034348#ent", "<e2>", "."], "h": {"id": "C0031716", "name": "C0031716#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0034348", "name": "C0034348#ent", "pos": [31, 32]}}
{"token": ["We", "describe", "a", "new", "form", "of", "a", "C1415740#ent", "<e1>", "the", "enzyme", "activities", "of", "delta", "3", "delta", "2-enoyl-CoA", "isomerase", "3-hydroxyacyl-CoA", "epimerase", "C0000404#ent", "<e2>", "L-3-hydroxyacyl-CoA", "forming", "2-trans-enoyl-CoA", "hydratase"], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0000404", "name": "C0000404#ent", "pos": [20, 21]}}
{"token": ["C1515406#ent", "<e1>", "a", "negative", "regulator", "of", "fetal", "liver", "growth", ",", "increased", "C1704823#ent", "<e2>", "mRNA", "levels", "48", "hours", "after", "the", "addition", "of", "the", "factor", ",", "whereas", "glucocorticoids", "had", "a", "negative", "effect"], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704823", "name": "C1704823#ent", "pos": [11, 12]}}
{"token": ["C0871189#ent", "<e1>", "not", "included", "under", "accepted", "definitions", "of", "premenstrual", "syndrome", "C0033046#ent", "<e2>", ")", "."], "h": {"id": "C0871189", "name": "C0871189#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033046", "name": "C0033046#ent", "pos": [10, 11]}}
{"token": ["C1538681#ent", "<e1>", "release", "following", "MPN-ECS", "was", "not", "appreciably", "affected", "in", "these", "rats", "nor", "did", "C1335834#ent", "<e2>", "alter", "the", "amplifying", "effects", "of", "LC-ES", "on", "C1538681#ent", "<e1>", "."], "h": {"id": "C1335834", "name": "C1335834#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1538681", "name": "C1538681#ent", "pos": [0, 1]}}
{"token": ["Receiver", "operating", "characteristic", "analysis", "that", "in", "our", "sample", "population", "the", "measurement", "of", "total", "C0885520#ent", "<e1>", "for", "the", "prediction", "of", "neonatal", "C0476273#ent", "<e2>", "to", "demonstrate", "an", "advantage", "over", "the", "measurement", "of", "unsaturated", "lecithin", "alone", "."], "h": {"id": "C0885520", "name": "C0885520#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [20, 21]}}
{"token": ["This", "novel", "gene", "(", "called", "C1744635#ent", "<e1>", ")", "belongs", "to", "a", "C1517488#ent", "<e2>", "members", "in", "several", "chromosome", "regions", "3q24-q25", ",", "6q22", ",", "9q21", ",", "12q13", ",", "18q12", ",", "20p12", "and", "Xq25", "."], "h": {"id": "C1744635", "name": "C1744635#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [11, 12]}}
{"token": ["Overexpression", "of", "dominant-negative", "mutants", "of", "beta-arrestin1-V53D", "and", "C1119970#ent", "<e1>", "I-K44A", "prevented", "agonist-mediated", "internalization", "of", "C1417064#ent", "<e2>", "."], "h": {"id": "C1119970", "name": "C1119970#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417064", "name": "C1417064#ent", "pos": [14, 15]}}
{"token": ["The", "binding", "property", "of", "some", "tertiary", "amines", "chlorpromazine", ",", "promethazine", "and", "imipramine", ")", "and", "quaternary", "ammonium", "compounds", "C0033448#ent", "<e1>", ",", "mepenzolate", "and", "C0006519#ent", "<e2>", ")", "for", "gastric", "mucin", "investigated", "."], "h": {"id": "C0033448", "name": "C0033448#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006519", "name": "C0006519#ent", "pos": [22, 23]}}
{"token": ["The", "cells", "were", "lysed", "with", "C0012789#ent", "<e1>", "at", "pH", "9", "and", "C1705446#ent", "<e2>", "was", "purified", "by", "ammonium", "sulfate", "precipitation", ",", "gel", "filtration", "Sephadex", "G-200", "and", "three", "isoelectric", "focusing", "steps", "."], "h": {"id": "C0012789", "name": "C0012789#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705446", "name": "C1705446#ent", "pos": [11, 12]}}
{"token": ["Inhibition", "of", "nitric", "oxide", "synthetase", "NOS", ")", "activity", "with", "C0390776#ent", "<e1>", "increased", "the", "percentage", "of", "leukemia", "cells", "depolarized", "mitochondria", "membranes", "after", "C0003402#ent", "<e2>"], "h": {"id": "C0390776", "name": "C0390776#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [21, 22]}}
{"token": ["When", "C0029904#ent", "<e1>", "was", "added", "to", "the", "corticosterone", "treated", "cells", "effect", "on", "the", "C1825410#ent", "<e2>", "was", "impaired", "."], "h": {"id": "C0029904", "name": "C0029904#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1825410", "name": "C1825410#ent", "pos": [13, 14]}}
{"token": ["Explotab", "showed", "a", "significant", "decrease", "in", "the", "C4283936#ent", "<e1>", "followed", "by", "C0010353#ent", "<e2>", "finally", "by", "Starch", "RX", "1500", "."], "h": {"id": "C4283936", "name": "C4283936#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010353", "name": "C0010353#ent", "pos": [11, 12]}}
{"token": ["The", "serum", "of", "over", "half", "of", "a", "group", "of", "acutely", "C0231218#ent", "<e1>", "patients", "agglutinated", "\"", "C0733854#ent", "<e2>", "'", "a", "fat", "emulsion", "on", "soya", "bean", "oil", "for", "intravenous", "infusion"], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0733854", "name": "C0733854#ent", "pos": [15, 16]}}
{"token": ["The", "heat", "shock", "treatment", "of", "the", "intact", "spinach", "plants", "resulted", "in", "a", "2.4-fold", "induction", "of", "the", "C3537327#ent", "<e1>", "and", "additionally", "facilitated", "association", "of", "this", "C1332924#ent", "<e2>", "with", "the", "mitochondrial", "membrane"], "h": {"id": "C3537327", "name": "C3537327#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332924", "name": "C1332924#ent", "pos": [24, 25]}}
{"token": ["Comparisons", "were", "made", "of", "the", "specific", "activities", "of", "fatty", "acyl-CoA", "synthetase", "C0243546#ent", "<e1>", "diacylglycerol", "acyltransferase", "the", "mitochondrial", "and", "microsomal", "forms", "of", "C1709420#ent", "<e2>", "in", "homogenates", "from", "cardiac", "myocytes", "ventricle", "muscle"], "h": {"id": "C0243546", "name": "C0243546#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1709420", "name": "C1709420#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", "with", "both", "control", "groups", "surfactant-depleted", "animals", "challenged", "with", "C4083008#ent", "<e1>", "and", "conventional", "ventilation", "high", "levels", "of", "interleukin", "(IL)-8", "tumour", "necrosis", "factor", "and", "C0027021#ent", "<e2>", "in", "bronchoalveolar", "lavage", "fluid", "5", "h", "of", "ventilation", "."], "h": {"id": "C4083008", "name": "C4083008#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [24, 25]}}
{"token": ["C0743178#ent", "<e1>", "an", "important", "cause", "of", "severe", "C0162429#ent", "<e2>", "and", "growth", "failure", "infancy", "."], "h": {"id": "C0743178", "name": "C0743178#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [7, 8]}}
{"token": ["PCP", "causes", "a", "range", "of", "effects", "that", "include", "hallucinations", ",", "delirium", ",", "disorientation", ",", "agitation", ",", "C0026837#ent", "<e1>", "ataxia", ",", "nystagmus", ",", "C0036572#ent", "<e2>", ",", "and", "stupor", "."], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [22, 23]}}
{"token": ["It", "may", "be", "included", "in", "the", "differential", "diagnoses", "nodular", "and/or", "pigmented", "C0037284#ent", "<e1>", "include", "melanoma", ",", "pyogranuloma", ",", "mycetoma", ",", "squamous", "cell", "carcinoma", "C0018469#ent", "<e2>", ",", "and", "onchocerciasis", "."], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018469", "name": "C0018469#ent", "pos": [23, 24]}}
{"token": ["C0025644#ent", "<e1>", ",", "which", "inhibits", "C1417245#ent", "<e2>", ",", "was", "also", "without", "effect", "."], "h": {"id": "C0025644", "name": "C0025644#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417245", "name": "C1417245#ent", "pos": [5, 6]}}
{"token": ["The", "presence", "of", "NADPH", "diaphorase", "staining", "compared", "with", "the", "immunohistochemical", "localization", "of", "four", "NADPH-dependent", "enzymes-neuronal", "(", "type", "I", ",", "inducible", "(", "type", "II", ",", "and", "endothelial", "(", "C0907532#ent", "<e1>", "NOS", ")", "and", "C0027310#ent", "<e2>"], "h": {"id": "C0907532", "name": "C0907532#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0027310", "name": "C0027310#ent", "pos": [32, 33]}}
{"token": ["To", "determine", "the", "safety", "and", "efficacy", "of", "intermittent", "C0001641#ent", "<e1>", "men", "with", "lower", "urinary", "tract", "symptoms", "C0574785#ent", "<e2>", ")", "in", "a", "prospective", "study"], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0574785", "name": "C0574785#ent", "pos": [16, 17]}}
{"token": ["Among", "these", "was", "the", "C1421309#ent", "<e1>", "also", "known", "as", "C1436157#ent", "<e2>", ")", ",", "which", "is", "involved", "in", "regulation", "of", "cellular", "ubiquitin", "levels", "."], "h": {"id": "C1421309", "name": "C1421309#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1436157", "name": "C1436157#ent", "pos": [9, 10]}}
{"token": ["GLUT1", "protein", "content", "of", "total", "membranes", "C0011860#ent", "<e1>", "subjects", "was", "decreased", "compared", "with", "control", "subjects", "while", "C2982484#ent", "<e2>", "levels", "were", "similar", "between", "groups", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [6, 7]}, "relation": "disease_has_associated_gene", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "therapeutic", "effects", "insulin-stimulated", "glucose", "disposal", "can", "be", "achieved", "in", "C0011860#ent", "<e1>", "subjects", "without", "altering", "C2982484#ent", "<e2>", "expression", "in", "muscle", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "suffering", "from", "C0023890#ent", "<e1>", "secondary", "gastroduodenal", "ulcers", "multiple", "erosions", "the", "5-week", "treatment", "either", "with", "C0051245#ent", "<e2>", "and", "platyphylline", "or", "gastrozepine", "provided", "approximately", "similar", "results", "and", "promoted", "ulcer", "and", "erosion", "healing", "half", "the", "cases", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0051245", "name": "C0051245#ent", "pos": [16, 17]}}
{"token": ["C2751310#ent", "<e1>", "FJHN", ")", "and", "medullary", "cystic", "kidney", "disease", "type", "2", "MCKD2", ")", "are", "autosomal", "dominant", "disorders", "by", "C0740394#ent", "<e2>", "the", "underexcretion", "type", ",", "juvenile", "gout", "chronic", "renal", "failure", "the", "adult", "."], "h": {"id": "C2751310", "name": "C2751310#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0740394", "name": "C0740394#ent", "pos": [18, 19]}}
{"token": ["Growth-associated", "protein-43", "GAP-43", ")", "and", "synaptosomal-associated", "protein-25", "SNAP-25", ")", "was", "analyzed", "by", "Western", "Blotting", "the", "mitochondrial", "transmembrane", "potential", "C0065610#ent", "<e1>", ")", "by", "fluorescence", "imaging", "and", "C0011501#ent", "<e2>", "(", "[3H]2-DG", ")", "uptake", "by", "scintillation", "spectrometry"], "h": {"id": "C0065610", "name": "C0065610#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0011501", "name": "C0011501#ent", "pos": [25, 26]}}
{"token": ["Implementation", "is", "through", "community", "drug", "distributors", "(", "CDDs", ")", "who", "distribute", "pre-packaged", "chloroquine", "plus", "C0700599#ent", "<e1>", "(", "HOMAPAK", ")", "free", "of", "charge", "to", "caretakers", "of", "C0009952#ent", "<e2>", "children", "."], "h": {"id": "C0700599", "name": "C0700599#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [25, 26]}}
{"token": ["The", "C0950080#ent", "<e1>", "this", "complex", "were", "identified", "as", "E2A", "and", "HeLa", "E-box", "binding", "protein", "C1420632#ent", "<e2>", ")", ",", "and", "overexpression", "of", "E2A", "and", "C1420632#ent", "<e2>", "resulted", "in", "activation", "of", "the", "pTalpha", "promoter", "."], "h": {"id": "C0950080", "name": "C0950080#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [14, 15]}}
{"token": ["C0012258#ent", "<e1>", "and", "other", "cardiac", "glycosides", "important", ",", "centuries-old", "drugs", "for", "treating", "C0018802#ent", "<e2>"], "h": {"id": "C0012258", "name": "C0012258#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "administration", "of", "C1415285#ent", "<e1>", "reduced", "the", "level", "of", "C1968833#ent", "<e2>", "in", "the", "peritoneal", "exudate", "cells"], "h": {"id": "C1415285", "name": "C1415285#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [11, 12]}}
{"token": ["Since", "KRM-1648", "is", "a", "rifamycin", "derivative", "we", "included", "some", "strains", "of", "Mycobacterium", "tuberculosis", "resistant", "to", "rifampin", "(", "C1424884#ent", "<e1>", ")", "among", "the", "C0206526#ent", "<e2>"], "h": {"id": "C1424884", "name": "C1424884#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0206526", "name": "C0206526#ent", "pos": [22, 23]}}
{"token": ["We", "expressed", "recombinant", "Fabs", "incorporating", "the", "VH", "and", "VL", "C1417679#ent", "<e1>", "from", "RV-specific", "B", "cell", "using", "a", "new", "modified", "bacterial", "C1414528#ent", "<e2>", "expression", "vector", "we", "describe", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414528", "name": "C1414528#ent", "pos": [20, 21]}}
{"token": ["C0380804#ent", "<e1>", "a", "lysosomal", "hydrolase", "removes", "long", "chain", "fatty", "acyl", "from", "modified", "cysteine", "residues", "in", "C0086376#ent", "<e2>", "."], "h": {"id": "C0380804", "name": "C0380804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}}
{"token": ["C0342731#ent", "<e1>", "MVA", ")", "and", "C0031485#ent", "<e2>", "(", "PKU", ")", "are", "inborn", "errors", "metabolism", "caused", "by", "deficiencies", "in", "the", "enzymes", "mevalonate", "kinase", "and", "phenylalanine", "4-hydroxylase", "respectively", "."], "h": {"id": "C0342731", "name": "C0342731#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031485", "name": "C0031485#ent", "pos": [5, 6]}}
{"token": ["The", "prostate", "androgen-regulated", "C4283882#ent", "<e1>", ")", "gene", "is", "ubiquitously", "C3889446#ent", "<e2>", "in", "prostate", "cancer", "PCa", ")", "cells", "and", "is", "involved", "in", "proliferation", "of", "PCa", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [9, 10]}}
{"token": ["We", "have", "compared", "the", "C4283882#ent", "<e1>", "of", "the", "individual", "receptors", "C3889446#ent", "<e2>", "transiently", "at", "high", "or", "at", "lower", "levels", "following", "stable", "transfection", "in", "LPA-nonresponsive", "RH7777", "cells", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [10, 11]}}
{"token": ["Differing", "from", "these", "findings", ",", "under", "C0017887#ent", "<e1>", "hypotensive", "anesthesia", "no", "difference", "from", "the", "control", "group", "observed", "in", "C1428360#ent", "<e2>", "in", "N-group", ",", "while", "in", "H-group", "C1428360#ent", "<e2>", "decreased", "significantly", "from", "the", "control", "value"], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [18, 19]}}
{"token": ["C0017887#ent", "<e1>", "increased", "global", "C1428360#ent", "<e2>", "while", "flow", "velocities", "decreased", "."], "h": {"id": "C0017887", "name": "C0017887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [4, 5]}}
{"token": ["In", "this", "study", "we", "examined", "whether", "subcutaneous", "administration", "amifostine", "can", "reduce", "the", "toxicity", "of", "a", "highly", "aggressive", "chemo-radiotherapy", "scheme", "C1522690#ent", "<e1>", "Caelyx", "and", "Docetaxel", "(", "C0699967#ent", "<e2>", "in", "non-small", "cell", "lung", "cancer"], "h": {"id": "C1522690", "name": "C1522690#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0699967", "name": "C0699967#ent", "pos": [25, 26]}}
{"token": ["Once", "the", "reaction", "has", "occurred", ",", "C1417932#ent", "<e1>", "no", "longer", "available", "to", "combine", "with", "and", "to", "activate", "C0035678#ent", "<e2>"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035678", "name": "C0035678#ent", "pos": [17, 18]}}
{"token": ["In", "the", "title", "compound", "[", "Cd(C12H8F2N3)2(C5H5N)2", "]", ",", "the", "C1705969#ent", "<e1>", "atom", "lies", "on", "a", "crystallographic", "twofold", "axis", "in", "space", "group", "C1428750#ent", "<e2>", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1428750", "name": "C1428750#ent", "pos": [21, 22]}}
{"token": ["Collagen-induced", "arthritis", "CIA", ")", "is", "a", "widely", "accepted", "model", "of", "C0004364#ent", "<e1>", "significant", "similarities", "to", "C0003873#ent", "<e2>", "humans", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "C0158995#ent", "<e1>", "not", "associated", "with", "birthweight", ",", "but", "was", "related", "to", "C0002871#ent", "<e2>", "at", "birth", "in", "infants", "born", "women", "who", "had", "only", "received", "active", "case", "management", "their", "pregnancies", "."], "h": {"id": "C0158995", "name": "C0158995#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [14, 15]}}
{"token": ["C0669365#ent", "<e1>", "expression", "of", "C1710602#ent", "<e2>", "in", "the", "chvD", "mutant", "strain", "restored", "virulence", ",", "supporting", "the", "hypothesis", "that", "ChvD", "controls", "virulence", "through", "effects", "on", "C1710602#ent", "<e2>", "expression", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1710602", "name": "C1710602#ent", "pos": [4, 5]}}
{"token": ["They", "include", "C1533126#ent", "<e1>", ",", "venlafaxine", ",", "duloxetine", ",", "MCI-225", "and", "C0771310#ent", "<e2>", ",", "however", ",", "only", "C1533126#ent", "<e1>", "is", "currently", "used", "in", "Japan", "."], "h": {"id": "C1533126", "name": "C1533126#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0771310", "name": "C0771310#ent", "pos": [11, 12]}}
{"token": ["A", "43-year-old", "man", "presented", "with", "splenomegaly", "and", "a", "20-year", "history", "of", "a", "neurologic", "disorder", "included", "C0038868#ent", "<e1>", "mild", "dementia", "and", "a", "C0026650#ent", "<e2>"], "h": {"id": "C0038868", "name": "C0038868#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [21, 22]}}
{"token": ["This", "ruled", "out", "C4277588#ent", "<e1>", "phospholipase", "C", "but", "raised", "the", "possibility", "of", "C0031671#ent", "<e2>", "hydrolysis", "of", "phosphatidylinositol", "."], "h": {"id": "C4277588", "name": "C4277588#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [12, 13]}}
{"token": ["The", "present", "study", "was", "designed", "to", "determine", "by", "means", "of", "video", "urodynamic", "study", "or", "not", "C3854305#ent", "<e1>", "be", "of", "the", "same", "nature", "as", "detrusor", "bladder", "neck", "dyssynergia", "C1997362#ent", "<e2>", "."], "h": {"id": "C3854305", "name": "C3854305#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1997362", "name": "C1997362#ent", "pos": [27, 28]}}
{"token": ["C0238106#ent", "<e1>", "present", "as", "severe", "C2118460#ent", "<e2>", "can", "carry", "a", "high", "mortality", ",", "especially", "in", "the", "aged", "."], "h": {"id": "C0238106", "name": "C0238106#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2118460", "name": "C2118460#ent", "pos": [5, 6]}}
{"token": ["An", "anaerobically", "inducible", "promoter", "of", "Pseudomonas", "aeruginosa", "which", "depends", "on", "the", "C1332409#ent", "<e1>", "(", "fumarate", "and", "nitrate", "reductase", "transcriptional", "regulator", "ANR", "anaerobic", "regulation", "of", "C0052332#ent", "<e2>", "nitrate", "reductase", "pathways", ",", "was", "fused", "to", "the", "structural", "lacZ", "gene", "Escherichia", "coli"], "h": {"id": "C1332409", "name": "C1332409#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0052332", "name": "C0052332#ent", "pos": [24, 25]}}
{"token": ["The", "complication", "of", "C0017668#ent", "<e1>", "and", "C0024790#ent", "<e2>", "is", "every", "rare", "and", "there", "has", "been", "no", "report", "of", "C0017668#ent", "<e1>", "in", "a", "case", "with", "C0024790#ent", "<e2>", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024790", "name": "C0024790#ent", "pos": [6, 7]}}
{"token": ["Although", "epicutaneous", "testing", "no", "positive", "reaction", "the", "C0521471#ent", "<e1>", "could", "be", "induced", "in", "identical", "sites", "by", "oral", "administration", "C0771029#ent", "<e2>", "."], "h": {"id": "C0521471", "name": "C0521471#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0771029", "name": "C0771029#ent", "pos": [18, 19]}}
{"token": ["However", ",", "other", "C3540772#ent", "<e1>", "of", "the", "catabolic", "pathway", "namely", ",", "N-acetylmannosamine-2-epimerase", ",", "N-acetylglucosamine", "kinase", "C0207230#ent", "<e2>", "induced", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0207230", "name": "C0207230#ent", "pos": [15, 16]}}
{"token": ["We", ",", "for", "the", "first", "time", ",", "demonstrate", "that", "binding", "of", "staphylococcal", "enterotoxin", "B", "C1415492#ent", "<e1>", "results", "in", "activation", "of", "C1569773#ent", "<e2>", "enzyme", ",", "epidermal", "growth", "factor", "receptor", "p38MAPK", ",", "and", "NF-kappaB", "inducing", "biphasic", "TNF-alpha", "production", "."], "h": {"id": "C1415492", "name": "C1415492#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1569773", "name": "C1569773#ent", "pos": [20, 21]}}
{"token": ["Recent", "work", "from", "our", "laboratory", "indicates", "that", "C1420295#ent", "<e1>", "expression", "of", "aromatase", "cytochrome", "P450", "C3254086#ent", "<e2>", ")", ",", "the", "enzyme", "responsible", "for", "estrogen", "biosynthesis", "is", "determined", ",", "in", "part", ",", "by", "the", "use", "of", "tissue-specific", "promoters"], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3254086", "name": "C3254086#ent", "pos": [14, 15]}}
{"token": ["Pulse-chase", "labeling", "indicated", "that", "the", "NP", "and", "C0086376#ent", "<e1>", "early", "and", "the", "M", "and", "C1257945#ent", "<e2>", "synthesized", "late", "were", "preferentially", "incorporated", "into", "virus", "relative", "to", "the", "other", "viral", "proteins"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1257945", "name": "C1257945#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "increasing", "brain", "GABA", "with", "C0283073#ent", "<e1>", "GAG", ")", ",", "a", "C1254351#ent", "<e2>", "that", "inhibits", "GABA", "transaminase", "were", "evaluated", "in", "ten", "patients", "with", "stable", "tardive", "dyskinesia", "a", "blind", "placebo-controlled", "trial"], "h": {"id": "C0283073", "name": "C0283073#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggested", "that", "the", "effects", "of", "C2697645#ent", "<e1>", "on", "reperfusion", "arrhythmias", "deteriorated", "in", "C0011860#ent", "<e2>", "rats", "."], "h": {"id": "C2697645", "name": "C2697645#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [14, 15]}}
{"token": ["Graves'", "ophthalmopathy", "C0432255#ent", "<e1>", ")", "and", "Graves'", "hyperthyroidism", "closely", "associated", "C0012634#ent", "<e2>", "and", "thought", "to", "be", "caused", "by", "the", "same", "autoimmune", "process"], "h": {"id": "C0432255", "name": "C0432255#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["Women", "with", "lower", "abdominal", "pain", "be", "assessed", "carefully", "and", "if", "PID", "is", "the", "cause", "they", "should", "be", "treated", "for", "C0018081#ent", "<e1>", ",", "chlamydial", "and", "anaerobic", "C0004623#ent", "<e2>"], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [19, 20]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [25, 26]}}
{"token": ["Phages", "displaying", "C0059102#ent", "<e1>", "were", "strongly", "enriched", "from", "background", "phages", "displaying", "unrelated", "C0086376#ent", "<e2>", "."], "h": {"id": "C0059102", "name": "C0059102#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["These", "studies", "have", "for", "the", "first", "time", "localized", "C1705323#ent", "<e1>", "to", "the", "C0008928#ent", "<e2>", "and", "provided", "evidence", "that", "the", "intercalated", "cells", "the", "C0008928#ent", "<e2>", "express", "both", "COX-1", "and", "C1705323#ent", "<e1>", "."], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [8, 9]}}
{"token": ["In", "this", "experimental", "study", "Sprague-Dawley", "rats", "treated", "with", "different", "ACE", "inhibitors", "enalapril", ",", "C0070426#ent", "<e1>", ",", "quinapril", ",", "ramipril", ",", "and", "C0076891#ent", "<e2>", ")", "at", "equihypotensive", "doses", "."], "h": {"id": "C0070426", "name": "C0070426#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0076891", "name": "C0076891#ent", "pos": [21, 22]}}
{"token": ["Levels", "of", "C3540820#ent", "<e1>", "distinguished", "diabetic", "from", "nondiabetic", "patients", "more", "reliably", "than", "amniotic", "fluid", "C4049859#ent", "<e2>", ")", "insulin", "or", "glucose", "."], "h": {"id": "C3540820", "name": "C3540820#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [14, 15]}}
{"token": ["Comparative", "analysis", "performed", "for", "human", ",", "primate", ",", "and", "rodent", "C0019562#ent", "<e1>", "genes", "and", "for", "a", "putative", "Caenorhabditis", "elegans", "C0019562#ent", "<e1>", "C1334043#ent", "<e1>", "identified", "by", "database", "analysis"], "h": {"id": "C0019562", "name": "C0019562#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [21, 22]}}
{"token": ["Staff", "have", "found", "that", "the", "stress", "of", "doing", "C0030193#ent", "<e1>", "children", "is", "reduced", "when", "C0700541#ent", "<e2>", "is", "used", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0700541", "name": "C0700541#ent", "pos": [14, 15]}}
{"token": ["The", "intensity", "of", "pain", "sensations", "by", "single", ",", "C0030193#ent", "<e1>", ",", "electrical", "stimuli", "to", "the", "primary", "hyperalgesic", "region", "reduced", "after", "C0700541#ent", "<e2>", "infusion", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0700541", "name": "C0700541#ent", "pos": [20, 21]}}
{"token": ["Expression", "of", "an", "HreP-His(6", ")", "tag", "fusion", "protein", "E.", "coli", "that", "C1422603#ent", "<e1>", "undergoes", "autocatalytic", "processing", "at", "a", "consensus", "cleavage", "site", "C1438155#ent", "<e2>", "thereby", "releasing", "the", "proprotein", "."], "h": {"id": "C1422603", "name": "C1422603#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1438155", "name": "C1438155#ent", "pos": [21, 22]}}
{"token": ["C2047520#ent", "<e1>", "an", "important", "risk", "factor", "the", "development", "of", "C0007222#ent", "<e2>"], "h": {"id": "C2047520", "name": "C2047520#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [9, 10]}}
{"token": ["These", "C3541394#ent", "<e1>", "were", "studied", "in", "C0036572#ent", "<e2>", ",", "convulsive", "and", "postconvulsive", "phases", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [6, 7]}}
{"token": ["Using", "two", "ODNs", "we", "corrected", "an", "inactivating", "mutation", "in", "the", "C0041484#ent", "<e1>", "introduced", "an", "activating", "mutation", "into", "the", "C1416655#ent", "<e2>", "a", "single", "albino", "mouse", "melanocyte", "."], "h": {"id": "C0041484", "name": "C0041484#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [18, 19]}}
{"token": ["Severe", "acute", "respiratory", "syndrome", "C1419818#ent", "<e1>", ")", "is", "a", "recently", "recognized", "and", "highly", "contagious", "C0221423#ent", "<e2>", "caused", "by", "a", "novel", "coronavirus", "."], "h": {"id": "C1419818", "name": "C1419818#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "describe", "the", "identification", "and", "expression", "pattern", "of", "C1424333#ent", "<e1>", ",", "a", "novel", "member", "of", "the", "heterogeneous", "group", "genes", "encoding", "C0086376#ent", "<e2>", "with", "LIM/double", "zinc", "finger", "domains", "."], "h": {"id": "C1424333", "name": "C1424333#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [21, 22]}}
{"token": ["C0242889#ent", "<e1>", "no", "effect", "on", "LAD", "cross-sectional", "area", "while", "C0028005#ent", "<e2>", "partially", "reversed", "the", "ethanol-induced", "vasoconstriction", "."], "h": {"id": "C0242889", "name": "C0242889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0028005", "name": "C0028005#ent", "pos": [9, 10]}}
{"token": ["The", "pyridoxal", "phosphate", "converted", "to", "the", "C0034265#ent", "<e1>", "form", "in", "the", "presence", "of", "excess", "C0017789#ent", "<e2>", "."], "h": {"id": "C0034265", "name": "C0034265#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [14, 15]}}
{"token": ["The", "C1537624#ent", "<e1>", "and", "Tct", "sites", "of", "C2984593#ent", "<e2>", "were", "mapped", "by", "S1", "nuclease", "analyses", "to", "nts", "13,637", "and", "11,408", ",", "respectively", "."], "h": {"id": "C1537624", "name": "C1537624#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2984593", "name": "C2984593#ent", "pos": [7, 8]}}
{"token": ["Conversely", ",", "C1333666#ent", "<e1>", "expression", "was", "suppressed", "by", "the", "over-expression", "of", "C0432233#ent", "<e2>", "."], "h": {"id": "C1333666", "name": "C1333666#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0432233", "name": "C0432233#ent", "pos": [11, 12]}}
{"token": ["C1418423#ent", "<e1>", "is", "the", "predominant", "C3828567#ent", "<e2>", "form", "in", "tracheal", "extracts", "C1418423#ent", "<e1>", "mRNA", "is", "expressed", "in", "smooth", "muscle", "muscarinic", "binding", "sites", "most", "abundant", "."], "h": {"id": "C3828567", "name": "C3828567#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418423", "name": "C1418423#ent", "pos": [0, 1]}}
{"token": ["Moreover", ",", "iodixanol", "density", "gradient", "analyses", "revealed", "that", "C1336654#ent", "<e1>", "knockdown", "altered", "the", "basal-state", "partitioning", "of", "C1420175#ent", "<e2>", "and", "IRAP", "within", "endosomal", "compartments", "apparently", "by", "shifting", "both", "proteins", "toward", "less", "buoyant", "compartments", "."], "h": {"id": "C1336654", "name": "C1336654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [16, 17]}}
{"token": ["A", "total", "of", "26", "C1875400#ent", "<e1>", "belonging", "to", "10", "clusters", "of", "related", "C1875400#ent", "<e1>", "were", "compared", "by", "pulsed-field", "gel", "electrophoresis", "with", "all", "related", "C1875400#ent", "<e1>", "giving", "identical", "C3469921#ent", "<e1>", "patterns", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3469921", "name": "C3469921#ent", "pos": [27, 28]}}
{"token": ["This", "study", "has", "shown", "that", "there", "is", "statistically", "significant", "in", "activity", "of", "C1424792#ent", "<e1>", "diabetic", "and", "non-diabetic", "patients", ",", "irrespectively", "of", "C0085096#ent", "<e2>", "presence", "."], "h": {"id": "C1424792", "name": "C1424792#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0085096", "name": "C0085096#ent", "pos": [21, 22]}}
{"token": ["In", "order", "to", "understand", "the", "pathology", "of", "C0015732#ent", "<e1>", ",", "it", "is", "important", "to", "investigate", "C0426359#ent", "<e2>", "urological", "and", "neurological", "examinations", "urodynamics", "."], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0426359", "name": "C0426359#ent", "pos": [15, 16]}}
{"token": ["To", "investigate", "the", "change", "of", "telomerase", "activity", "C0087071#ent", "<e1>", "hTERT", ")", "gene", "expression", "HL-60", "cells", "transfected", "with", "C1883559#ent", "<e2>", "C1883559#ent", "<e2>", "introduced", "into", "HL-60", "cells", "Lipofectin", "transfection"], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [17, 18]}}
{"token": ["Going", "through", "examples", "of", "endogenous", "psychoses", ",", "psychosomatic", "illnesses", "and", "C0683323#ent", "<e1>", "is", "pointed", "out", ",", "that", "being", "C0231218#ent", "<e2>", "can", "not", "be", "early", "differentiated", "in", "either", "being", "physically", "or", "mentally", "ill"], "h": {"id": "C0683323", "name": "C0683323#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "the", "suppression", "of", "P450", "by", "C0010592#ent", "<e1>", "may", "involve", "C3539616#ent", "<e2>", "as", "an", "intermediate", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "C0010592#ent", "<e1>", "does", "not", "seem", "to", "alter", "C3539616#ent", "<e2>", "levels", "as", "a", "mediating", "event", "in", "suppressing", "P450", "expression", "and", "activity", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [10, 11]}}
{"token": ["C0000608#ent", "<e1>", "was", "found", "to", "inhibit", "the", "intrinsic", "activation", "of", "C1418485#ent", "<e2>", "without", "inhibiting", "the", "already", "active", "molecule"], "h": {"id": "C0000608", "name": "C0000608#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418485", "name": "C1418485#ent", "pos": [10, 11]}}
{"token": ["Two", "isoforms", "of", "C1565860#ent", "<e1>", "exist", ",", "designated", "C4284184#ent", "<e2>", "and", "COX2", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4284184", "name": "C4284184#ent", "pos": [8, 9]}}
{"token": ["We", "found", "that", ",", "in", "SEG1", "EA", "cells", "the", "acid-induced", "increase", "in", "prostaglandin", "E2", "PGE2", ")", "production", "was", "mediated", "by", "activation", "of", "C1565860#ent", "<e1>", "(", "COX2", ")", "but", "not", "by", "C4284184#ent", "<e2>", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C4284184", "name": "C4284184#ent", "pos": [30, 31]}}
{"token": ["The", "limited", "avidity", "of", "C0276180#ent", "<e1>", "human", "beings", "indicates", "that", "monkeypox", "is", "probably", "a", "C0043528#ent", "<e2>", ",", "although", "the", "animal", "reservoir(s", ")", "have", "not", "yet", "been", "identified", "."], "h": {"id": "C0276180", "name": "C0276180#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [14, 15]}}
{"token": ["Human", "C0276180#ent", "<e1>", "is", "a", "C0043528#ent", "<e2>", "that", "occurs", "sporadically", "in", "the", "tropical", "rainforest", "western", "and", "central", "Africa"], "h": {"id": "C0276180", "name": "C0276180#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [5, 6]}}
{"token": ["These", "studies", "show", "that", "ExoS", ",", "a", "TLR", "C0243192#ent", "<e1>", ",", "requires", "direct", "binding", "to", "C1539614#ent", "<e2>", "for", "optimal", "signaling", ",", "which", "suggests", "that", "C1539614#ent", "<e2>", "are", "possible", "therapeutic", "targets", "in", "cystic", "fibrosis"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539614", "name": "C1539614#ent", "pos": [15, 16]}}
{"token": ["Barbiturate", "cytotoxicity", "primary", "cultures", "cerebral", "cortex", "neurons", "was", "only", "apparent", "with", "C0002640#ent", "<e1>", ",", "pentobarbital", "and", "C0039925#ent", "<e2>", ",", "in", "which", "carbon", "5", "of", "the", "parent", "barbiturate", "ring", "modified", "with", "a", "methyl", "substituted", "4-carbon", "chain", "."], "h": {"id": "C0002640", "name": "C0002640#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [16, 17]}}
{"token": ["On", "the", "manual", "pointing", "C1416596#ent", "<e1>", ",", "children", "with", "C1422826#ent", "<e2>", "made", "inconsistent", "responses", "towards", "the", "targets", "in", "all", "three", "conditions", "(", "visual", ",", "visual-proprioceptive", "and", "proprioceptive", "condition", ")", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422826", "name": "C1422826#ent", "pos": [9, 10]}}
{"token": ["The", "p160", "coactivators", "bind", "to", "and", "potentiate", "transcriptional", "activation", "nuclear", "receptors", "recruiting", "secondary", "coactivators", "such", "as", "the", "histone", "acetyltransferases", "p300", "and", "C1538565#ent", "<e1>", "and", "the", "protein", "methyltransferase", "C1428067#ent", "<e2>", "."], "h": {"id": "C1538565", "name": "C1538565#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1428067", "name": "C1428067#ent", "pos": [27, 28]}}
{"token": ["Calibration", "curves", "C1420400#ent", "<e1>", "appreciably", "lower", "for", "(", "N", ",", "O-didansyl", ")", "aminophenol", "C0041484#ent", "<e2>", "and", "(", "N", ",", "O", ",", "O'-tridansyl", ")", "DA", "and", "SAL", "than", "for", "N-dansylamines", "."], "h": {"id": "C1420400", "name": "C1420400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0041484", "name": "C0041484#ent", "pos": [13, 14]}}
{"token": ["C0037889#ent", "<e1>", "HX", ")", "is", "a", "rare", "C1263988#ent", "<e2>", "to", "dehydrated", "red", "blood", "cells", "RBCs", ")", "."], "h": {"id": "C0037889", "name": "C0037889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1263988", "name": "C1263988#ent", "pos": [7, 8]}}
{"token": ["The", "cDNA", "contains", "an", "C0079941#ent", "<e1>", "a", "new", "C0919336#ent", "<e2>", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [8, 9]}}
{"token": ["Three", "patients", "with", "C0600260#ent", "<e1>", "COPD", ")", "and", "C0026896#ent", "<e2>", "pulmonary", "symptoms", "worsened", "by", "therapy", "with", "cholinesterase", "inhibitors", "improved", "by", "inhaled", "ipratropium", "bromide"], "h": {"id": "C0600260", "name": "C0600260#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "we", "have", "developed", "a", "new", "specific", "ELISA", "for", "serum", "ucOC", ",", "with", "low", "cross-reactivity", "with", "carboxylated", "C3539565#ent", "<e1>", "and", "increased", "specificity", "and", "sensitivity", "over", "the", "C1705662#ent", "<e2>", "assay", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705662", "name": "C1705662#ent", "pos": [28, 29]}}
{"token": ["Liposomes", "composed", "of", "C0000039#ent", "<e1>", "the", "lowest", "liposomal", "C0012695#ent", "<e2>", "uptake", "observed", "in", "liver", "and", "marrow", "but", "modrate", "uptake", "by", "lungs", "."], "h": {"id": "C0000039", "name": "C0000039#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [8, 9]}}
{"token": ["L-R", "shunt", "flow", "was", "decreased", "by", "C0282210#ent", "<e1>", "and", "increased", "by", "C0086140#ent", "<e2>", "loading", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [11, 12]}}
{"token": ["C1332124#ent", "<e1>", "is", "caused", "by", "gain", "of", "function", "mutations", "in", "the", "C1414605#ent", "<e2>", "FGF23", ")", "."], "h": {"id": "C1332124", "name": "C1332124#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414605", "name": "C1414605#ent", "pos": [11, 12]}}
{"token": ["3", "The", "vasodilator", "effect", "fenoldopam", "was", "abolished", "by", "sectioning", "of", "the", "lumbar", "sympathetic", "nerves", "by", "pretreatment", "with", "the", "C3536867#ent", "<e1>", "hexamethonium", "or", "the", "alpha-adrenoreceptor", "antagonists", "C0031448#ent", "<e2>", "and", "prazosin", "."], "h": {"id": "C3536867", "name": "C3536867#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031448", "name": "C0031448#ent", "pos": [25, 26]}}
{"token": ["Subsequent", "research", "showed", "that", "C2830173#ent", "<e1>", "activated", "by", "C1420714#ent", "<e2>", "TGase", "2", "."], "h": {"id": "C2830173", "name": "C2830173#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420714", "name": "C1420714#ent", "pos": [8, 9]}}
{"token": ["Inhibition", "of", "PI3K", "C0251991#ent", "<e1>", "prevented", "EGF-induced", "increases", "in", "GAPDH", "and", "C1418274#ent", "<e2>", "abundance", "in", "NRK-52E", "renal", "tubular", "cells"], "h": {"id": "C0251991", "name": "C0251991#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418274", "name": "C1418274#ent", "pos": [11, 12]}}
{"token": ["The", "presumed", "role", "of", "the", "human", "liver-", "and", "intestinal-dominant", "carboxylesterases", "C1419431#ent", "<e1>", "and", "hCE2", ",", "respectively", ",", "in", "the", "conversion", "of", "C2683417#ent", "<e2>", "to", "R-95913", "was", "determined", "using", "expressed", "and", "purified", "enzymes", "."], "h": {"id": "C1419431", "name": "C1419431#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2683417", "name": "C2683417#ent", "pos": [21, 22]}}
{"token": ["It", "was", "confirmed", "that", "C0025023#ent", "<e1>", "is", "very", "effective", ",", "broad-spectrum", "C0003158#ent", "<e2>", ",", "especially", "against", "Ascaris", ",", "Ancylostoma", ",", "Trichostrongylus", "and", "Enterobius", "infections"], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [4, 5]}, "relation": "has_therapeutic_class", "t": {"id": "C0003158", "name": "C0003158#ent", "pos": [11, 12]}}
{"token": ["Alternatively", ",", "the", "autoimmune", "process", "led", "to", "C0011854#ent", "<e1>", "may", "also", "trigger", "an", "C3542501#ent", "<e2>", "vasculitis", "(", "patient", "2", "or", "demyelinative", "nerve", "lesions", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3542501", "name": "C3542501#ent", "pos": [13, 14]}}
{"token": ["C1414542#ent", "<e1>", "a", "hereditary", "disease", "connective", "tissue", "predominant", "involvement", "of", "cardiovascular", "system", "skeleton", "and", "C0235267#ent", "<e2>", "."], "h": {"id": "C1414542", "name": "C1414542#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "show", "that", "exposure", "to", "C1418938#ent", "<e1>", "is", "necessary", "to", "allow", "C1427643#ent", "<e2>", "LM", "expression", "in", "postmetamorphic", "froglets", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1427643", "name": "C1427643#ent", "pos": [13, 14]}}
{"token": ["We", "report", "a", "young", "man", "with", "myoclonic", "dystonia", "displayed", "only", "little", "response", "to", "alcohol", "but", "improved", "significantly", "with", "a", "combination", "of", "C0037567#ent", "<e1>", "myoclonus", "and", "trihexiphenidyl", "hydrochloride", "C0393593#ent", "<e2>", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0393593", "name": "C0393593#ent", "pos": [27, 28]}}
{"token": ["In", "addition", "to", "the", "chemokine", "receptor", "protein", "Duffy", "blood", "group", "antigen", "receptor", "chemokines", ",", "these", "factors", "include", "the", "C0907533#ent", "<e1>", "expressed", "chemokine", "C1366566#ent", "<e2>", ",", "which", "is", "responsible", "for", "the", "accumulation", "of", "pathogenic", "CCR10", "+", "T", "lymphocytes", "human", "inflammatory", "skin", "diseases"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1366566", "name": "C1366566#ent", "pos": [22, 23]}}
{"token": ["Bladder", "dysfunction", "C0017178#ent", "<e1>", "common", "complications", "of", "diabetes", "mellitus", "are", "attributed", "in", "part", "to", "C0031117#ent", "<e2>"], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [14, 15]}}
{"token": ["C0005059#ent", "<e1>", "is", "a", "required", "C0812325#ent", "<e2>"], "h": {"id": "C0005059", "name": "C0005059#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [5, 6]}}
{"token": ["In", "this", "study", ",", "we", "examined", "the", "localization", "of", "proteoglycans", "and", "C0009325#ent", "<e1>", "in", "the", "granulomatous", "lung", "conditions", "sarcoidosis", ",", "extrinsic", "allergic", "alveolitis", "EAA", ")", "and", "C0041296#ent", "<e2>", "(", "TB", ")", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [26, 27]}}
{"token": ["Molecular", "basis", "the", "C0014442#ent", "<e1>", "induction", "by", "2-AP", "was", "studied", "in", "comparison", "with", "C0069456#ent", "<e2>", "(", "Olt", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0069456", "name": "C0069456#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "evidence", "is", "presented", "for", "C1336604#ent", "<e1>", "also", "being", "C0669365#ent", "<e2>", "expressed", "at", "certain", "stages", "in", "the", "development", "of", "both", "tomato", "and", "potato", "flowers"], "h": {"id": "C1336604", "name": "C1336604#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}}
{"token": ["C4082937#ent", "<e1>", "NEC", ")", "is", "usually", "considered", "to", "be", "a", "C0021290#ent", "<e2>", "and", "is", "rarely", "described", "beyond", "the", "newborn", "period", "."], "h": {"id": "C4082937", "name": "C4082937#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0021290", "name": "C0021290#ent", "pos": [10, 11]}}
{"token": ["The", "C3711161#ent", "<e1>", "ABC", ")", "transporter", "superfamily", "a", "large", "C1517488#ent", "<e2>", "has", "been", "highly", "conserved", "throughout", "evolution", "."], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1517488", "name": "C1517488#ent", "pos": [9, 10]}}
{"token": ["In", "vivo", "C0173383#ent", "<e1>", "activity", "was", "confirmed", "by", "functional", "expression", "of", "the", "corresponding", "genes", "in", "Escherichia", "coli", "and", "C0173383#ent", "<e1>", "activity", "could", "also", "be", "measured", "in", "vitro", "the", "C3540790#ent", "<e1>", "."], "h": {"id": "C0173383", "name": "C0173383#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [28, 29]}}
{"token": ["Cells", "which", "were", "furnished", "with", "affinity-purified", "antibody", "to", "the", "C1336838#ent", "<e1>", "the", "introduction", "of", "the", "C0031727#ent", "<e2>", "remained", "unresponsive", "to", "the", "effects", "of", "atriopeptin", "."], "h": {"id": "C1336838", "name": "C1336838#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [15, 16]}}
{"token": ["Clinical", "symptoms", "occur", "within", "the", "first", "3", "months", "after", "transplantation", ",", "sometimes", "as", "early", "as", "2", "weeks", "post", "transplant", "and", "involve", "C0027059#ent", "<e1>", "encephalitis", "or", "C3714636#ent", "<e2>", "."], "h": {"id": "C0027059", "name": "C0027059#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [25, 26]}}
{"token": ["Operative", "complications", "significantly", "higher", "in", "the", "case", "of", "emergency", "procedures", "impaction", "of", "the", "C0006863#ent", "<e1>", "by", "multiple", "stones", "and", "associated", "C0149520#ent", "<e2>"], "h": {"id": "C0006863", "name": "C0006863#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0149520", "name": "C0149520#ent", "pos": [20, 21]}}
{"token": ["Some", "C0003290#ent", "<e1>", "as", "clomipramine", "and", "imipramine", "are", "effective", "in", "controlling", "C0007384#ent", "<e2>", ",", "sleep", "paralysis", "hypnagogic", "hallucination"], "h": {"id": "C0003290", "name": "C0003290#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007384", "name": "C0007384#ent", "pos": [11, 12]}}
{"token": ["Tempeh", "is", "a", "traditional", "Indonesian", "soybean-fermented", "food", "produced", "by", "filamentous", "fungi", "Rhizopus", "sp.", "Fusarium", "sp.", "isolated", "and", "sequenced", "the", "genomic", "gene", "a", "cDNA", "clone", "encoding", "a", "novel", "C1947941#ent", "<e1>", "(", "FP", ")", "from", "Fusarium", "sp.", "C1332672#ent", "<e2>", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1332672", "name": "C1332672#ent", "pos": [35, 36]}}
{"token": ["Our", "results", "suggest", "that", "the", "clinical", "pattern", "parthenium", "dermatitis", "undergoes", "a", "significant", "change", "after", "the", "onset", ",", "i.e.", "progresses", "from", "airborne", "C0011616#ent", "<e1>", "mixed", "pattern", "or", "C1956346#ent", "<e2>", "pattern", "."], "h": {"id": "C0011616", "name": "C0011616#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [26, 27]}}
{"token": ["C0020625#ent", "<e1>", "hypochloremic", "dehydration", "with", "C0220983#ent", "<e2>", "a", "rare", "but", "typical", "presentation", "of", "CF", "in", "infants", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0220983", "name": "C0220983#ent", "pos": [5, 6]}}
{"token": ["C1419289#ent", "<e1>", "encodes", "a", "protein", "similar", "to", "C3538823#ent", "<e2>", ",", "a", "mammalian", "protein", "binds", "Rb", "."], "h": {"id": "C1419289", "name": "C1419289#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538823", "name": "C3538823#ent", "pos": [7, 8]}}
{"token": ["We", "reported", "previously", "that", "overexpression", "of", "p202", ",", "an", "C3273299#ent", "<e1>", "cell", "growth", "negatively", "regulates", "the", "transcriptional", "activity", "C1705526#ent", "<e2>", "."], "h": {"id": "C3273299", "name": "C3273299#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [18, 19]}}
{"token": ["C0857751#ent", "<e1>", "ulcers", "and", "xerostomia", "are", "the", "main", "oral", "side", "effects", "associated", "with", "C0282519#ent", "<e2>"], "h": {"id": "C0857751", "name": "C0857751#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282519", "name": "C0282519#ent", "pos": [13, 14]}}
{"token": ["Buformin", "treatment", "resulted", "in", "significant", "increase", "of", "blood", "glucose", "values", "180", "and", "360", "min", "after", "oral", "glucose", "challenge", "in", "considerable", "improvement", "of", "hypoglycemia", "in", "nine", "obese", "patients", "with", "C0271710#ent", "<e1>", "in", "the", "patient", "with", "C0271650#ent", "<e2>"], "h": {"id": "C0271710", "name": "C0271710#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0271650", "name": "C0271650#ent", "pos": [34, 35]}}
{"token": ["The", "association", "of", "the", "two", "C0086376#ent", "<e1>", "raises", "the", "intriguing", "possibility", "that", "nucleolin", "binding", "C0287666#ent", "<e2>", "may", "function", "to", "regulate", "homologous", "recombinational", "repair", "chromosomal", "DNA"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0287666", "name": "C0287666#ent", "pos": [14, 15]}}
{"token": ["Important", "C0086376#ent", "<e1>", "in", "this", "pathway", "are", "C0287666#ent", "<e2>", "and", "Rad54", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0287666", "name": "C0287666#ent", "pos": [7, 8]}}
{"token": ["Both", "NET", "and", "C3494348#ent", "<e1>", "nisoxetine", "and", "fluoxetine", ")", "produced", "significant", "CPPs", "in", "DAT", "C1416746#ent", "<e2>", "mice", ",", "but", "not", "in", "wild-type", "(", "WT", ")", "mice", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416746", "name": "C1416746#ent", "pos": [14, 15]}}
{"token": ["One", "previously", "untreated", "C1851585#ent", "<e1>", "patient", "received", "C0042682#ent", "<e2>", "without", "prednisone", "and", "obtained", "a", "complete", "long-lasting", "remission", "."], "h": {"id": "C1851585", "name": "C1851585#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042682", "name": "C0042682#ent", "pos": [7, 8]}}
{"token": ["The", "most", "common", "symptoms", "of", "C1961835#ent", "<e1>", "hepatosplenomegaly", "and", "anemia", "and", "thrombocytopenia", "due", "to", "C0020532#ent", "<e2>", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0020532", "name": "C0020532#ent", "pos": [14, 15]}}
{"token": ["In", "another", "child", "afflicted", "with", "C1961835#ent", "<e1>", "whom", "splenectomy", "was", "performed", "for", "severe", "splenomegaly", "and", "C0020532#ent", "<e2>", "there", "was", "a", "progressive", "increase", "in", "the", "level", "of", "this", "lipid", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0020532", "name": "C0020532#ent", "pos": [15, 16]}}
{"token": ["C1961835#ent", "<e1>", "the", "most", "prevalent", "lysosomal", "storage", "disorder", "is", "characterized", "by", "hepatosplenomegaly", ",", "C0020532#ent", "<e2>", ",", "and", "rarely", ",", "neurological", "involvement", "."], "h": {"id": "C1961835", "name": "C1961835#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020532", "name": "C0020532#ent", "pos": [13, 14]}}
{"token": ["The", "cationic-exchange", "separation", "method", "developed", "has", "enabled", "the", "detection", "of", "six", "arsenic", "species", "AsIII", ",", "C1417198#ent", "<e1>", ",", "AsV", ",", "DMA", ",", "C2348921#ent", "<e2>", ",", "TMAO", ")", "in", "different", "landfill", "leachates", "."], "h": {"id": "C1417198", "name": "C1417198#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2348921", "name": "C2348921#ent", "pos": [22, 23]}}
{"token": ["Amitriptyline", ",", "the", "most", "potent", "compound", ",", "had", "214", "X", "the", "potency", "of", "the", "weakest", ",", "C0057223#ent", "<e1>", ",", "but", "was", "itself", "20", "X", "weaker", "than", "C0004259#ent", "<e2>", "."], "h": {"id": "C0057223", "name": "C0057223#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [26, 27]}}
{"token": ["Other", "genetic", "abnormalities", "associated", "with", "C1848862#ent", "<e1>", "range", "from", "defective", "C0524889#ent", "<e2>", "to", "non-functional", "signaling", "molecules"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0524889", "name": "C0524889#ent", "pos": [10, 11]}}
{"token": ["No", "antigenic", "relatedness", "between", "intracellular", "C0002272#ent", "<e1>", "and", "glucosyl-", "and", "fructosyl-", "C0085748#ent", "<e2>", "was", "detected", "since", "cross-reactivity", "with", "antibody", "prepared", "against", "either", "enzyme", "fraction", "was", "not", "observed", "after", "immunodiffusion", "."], "h": {"id": "C0002272", "name": "C0002272#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085748", "name": "C0085748#ent", "pos": [11, 12]}}
{"token": ["C0165477#ent", "<e1>", "is", "a", "newly", "developed", "C3536837#ent", "<e2>", "ACEI", ")", "whose", "characteristic", "is", "that", "it", "undergoes", "hepatic", "excretion", "."], "h": {"id": "C0165477", "name": "C0165477#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536837", "name": "C3536837#ent", "pos": [6, 7]}}
{"token": ["In", "contrast", "to", "those", "occurring", "in", "immunocompetent", "patients", ",", "nearly", "all", "C0019686#ent", "<e1>", "PBLs", "are", "associated", "with", "Epstein-Barr", "virus", "C0149678#ent", "<e2>", ")", "."], "h": {"id": "C0019686", "name": "C0019686#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [19, 20]}}
{"token": ["Phenylketonuria", "(", "PKU", ",", "MIM", "261600", ";", "C4285344#ent", "<e1>", "results", "from", "mutations", "in", "the", "phenylalanine", "hydroxylase", "C3203102#ent", "<e2>", ")", "gene", "."], "h": {"id": "C4285344", "name": "C4285344#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3203102", "name": "C3203102#ent", "pos": [16, 17]}}
{"token": ["Examples", "are", "the", "C0013261#ent", "<e1>", "the", "Marcus", "Gunn", "phenomenon", "or", "secondary", "C0234362#ent", "<e2>", "oculomotor", "nerve", "palsy"], "h": {"id": "C0013261", "name": "C0013261#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0234362", "name": "C0234362#ent", "pos": [11, 12]}}
{"token": ["AF4", "antibodies", "be", "useful", "for", "further", "elucidation", "of", "the", "function", "of", "C1826604#ent", "<e1>", "in", "normal", "cellular", "physiology", "as", "well", "as", "the", "function", "of", "C2674774#ent", "<e2>", "in", "leukemogenesis", "."], "h": {"id": "C1826604", "name": "C1826604#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C2674774", "name": "C2674774#ent", "pos": [23, 24]}}
{"token": ["Repeated", "dosing", "of", "1", "mg", "kg-1", "C0014025#ent", "<e1>", "also", "significantly", "augmented", "the", "C0006931#ent", "<e2>"], "h": {"id": "C0014025", "name": "C0014025#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", "to", "C1367553#ent", "<e1>", ",", "Lp(a)", "not", "be", "activated", "by", "C0078956#ent", "<e2>", ",", "streptokinase", "or", "urokinase", "to", "give", "proteolytic", "activity"], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [11, 12]}}
{"token": ["trans-PGE2", "was", "found", "to", "enhance", "C1367553#ent", "<e1>", "(", "PLG", ")", "activation", "mediated", "by", "tissue-type", "plasminogen", "activator", "C0078956#ent", "<e2>", ")", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [16, 17]}}
{"token": ["The", "patient", "showed", "C0151559#ent", "<e1>", "bradycardia", ",", "hypotonia", ")", "with", "C0221155#ent", "<e2>", "peripheral", "vasoconstriction"], "h": {"id": "C0151559", "name": "C0151559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0221155", "name": "C0221155#ent", "pos": [10, 11]}}
{"token": ["Eight", "weeks", "after", "implantation", "of", "the", "DOCA", "pellets", ",", "C1420175#ent", "<e1>", "expression", "decreased", "by", "75", "%", "in", "aortas", "of", "C0003364#ent", "<e2>", "mice", ",", "but", "not", "in", "C1420175#ent", "<e1>", "TG", "hypertensive", "aortas", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420175", "name": "C1420175#ent", "pos": [9, 10]}}
{"token": ["The", "reviewed", "data", "indicate", "that", "METH", "and", "C0079522#ent", "<e1>", "including", "gp120", ",", "gp41", ",", "Tat", ",", "C0079405#ent", "<e2>", "and", "Nef", ",", "converge", "on", "various", "caspase-dependent", "death", "pathways", "to", "cause", "neuronal", "apoptosis"], "h": {"id": "C0079522", "name": "C0079522#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079405", "name": "C0079405#ent", "pos": [16, 17]}}
{"token": ["The", "sympathetic", "nervous", "system", "blocked", "at", "the", "peripheral", "alpha1-receptor", "by", "prazosin", ",", "at", "central", "nervous", "system", "alpha-receptor", "sites", "via", "alpha-adrenoceptor", "agonism", "by", "C0009014#ent", "<e1>", ",", "and", "at", "peripheral", "and", "central", "sites", "C0021252#ent", "<e2>", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0021252", "name": "C0021252#ent", "pos": [31, 32]}}
{"token": ["Occurrence", "of", "Hodgkin", "lymphoma", "C1416867#ent", "<e1>", ")", "has", "been", "reported", "in", "2", "families", "with", "C1328840#ent", "<e2>", "."], "h": {"id": "C1416867", "name": "C1416867#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1328840", "name": "C1328840#ent", "pos": [14, 15]}}
{"token": ["The", "authors", "identified", "eight", "patients", "with", "Rubinstein-Taybi", "syndrome", "C1705776#ent", "<e1>", ")", "and", "examined", "how", "the", "underlying", "conditions", "of", "this", "C0039082#ent", "<e2>", "can", "impede", "the", "detection", "of", "symptoms", "associated", "with", "tethered", "spinal", "cord"], "h": {"id": "C1705776", "name": "C1705776#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [19, 20]}}
{"token": ["Our", "findings", "suggest", "that", "severe", "C1705776#ent", "<e1>", "is", "distinct", "from", "C1705776#ent", "<e1>", "and", "represents", "a", "novel", "true", "contiguous", "C0039082#ent", "<e1>", "chromosome", "16p13.3", "deletion", "syndrome", "."], "h": {"id": "C1705776", "name": "C1705776#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [18, 19]}}
{"token": ["The", "C3653979#ent", "<e1>", "sorbinil", "and", "C0085066#ent", "<e2>", "mitigated", "endotoxin-induced", "pulmonary", "hypertension", "ET-1", "stimulation", ",", "and", "differential", "ET(B", ")", "receptor", "regulation", "."], "h": {"id": "C3653979", "name": "C3653979#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085066", "name": "C0085066#ent", "pos": [5, 6]}}
{"token": ["The", "present", "study", "was", "thus", "undertaken", "to", "investigate", "the", "feasibility", "of", "C0003209#ent", "<e1>", "prevent", "CIA", "by", "delivery", "of", "C0017337#ent", "<e2>", "encoding", "truncated", "sCR1", "(", "tsCR1", ")", "and", "dimeric", "tsCR1-Ig", "."], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["Butyrate", "activation", "of", "p21WAF1", "is", "potentiated", "by", "C1421639#ent", "<e1>", "through", "the", "recruitment", "of", "the", "C3275267#ent", "<e2>", "p300", ",", "while", "chronic", "stimulation", "butyrate", "increases", "ZBP-89", "gene", "expression", "correlating", "with", "cell", "differentiation"], "h": {"id": "C1421639", "name": "C1421639#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3275267", "name": "C3275267#ent", "pos": [14, 15]}}
{"token": ["Pretreatment", "of", "GT1", "-", "7", "cells", "for", "2", "h", "with", "morphine", ",", "suppressed", "the", "C1706334#ent", "<e1>", "response", "to", "C0022245#ent", "<e2>", "and", "dopamine", "but", "had", "no", "apparent", "effect", "on", "serotonin-induced", "C1706334#ent", "<e1>", "release", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1706334", "name": "C1706334#ent", "pos": [14, 15]}}
{"token": ["C1414141#ent", "<e1>", "is", "a", "lymphocyte", "C1447020#ent", "<e2>", "DPP", "IV", ",", "which", "is", "able", "to", "inactivate", "chemokines", "such", "as", "RANTES", "or", "eotaxin", "by", "cleaving", "dipeptides", "the", "NH2-terminus", "of", "proteins", "."], "h": {"id": "C1414141", "name": "C1414141#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1447020", "name": "C1447020#ent", "pos": [5, 6]}}
{"token": ["Apparent", "C1839259#ent", "<e1>", "values", "for", "alpha-ANP", "in", "AM", ",", "C1425440#ent", "<e2>", ",", "and", "SFO", "were", "1", "-", "6", "nM", "and", "they", "were", "lowest", "in", "SHR", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1425440", "name": "C1425440#ent", "pos": [9, 10]}}
{"token": ["Further", "50", "mostly", "missense", "mutations", "C1416877#ent", "<e1>", "result", "in", "autosomal-dominant", "EDMD", ",", "autosomal-recessive", "EDMD", ",", "C1834653#ent", "<e2>", ",", "DCM-CD", ",", "FPLD", ",", "or", "CMT2B", "."], "h": {"id": "C1416877", "name": "C1416877#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1834653", "name": "C1834653#ent", "pos": [15, 16]}}
{"token": ["C1422484#ent", "<e1>", "have", "both", "the", "ability", "to", "suppress", "C1415615#ent", "<e2>", "in", "cells", "which", "possess", "low", "density", "lipoproteins", "receptors", "to", "activate", "the", "enzyme", "in", "receptor-negative", "cells", "."], "h": {"id": "C1422484", "name": "C1422484#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415615", "name": "C1415615#ent", "pos": [8, 9]}}
{"token": ["Our", "findings", "demonstrate", "that", "thalamocortical", "axons", "are", "directed", "by", "sequential", ",", "positional", "cues", "within", "the", "C0001614#ent", "<e1>", "and", "implicate", "C1333539#ent", "<e2>", "as", "an", "indirect", "regulator", "of", "thalamocortical", "innervation", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333539", "name": "C1333539#ent", "pos": [19, 20]}}
{"token": ["Our", "results", "demonstrated", "that", "C1333570#ent", "<e1>", "exerts", "antioxidant", "effects", "in", "vitro", "indicating", "the", "therapeutic", "potential", "of", "this", "C0013227#ent", "<e2>", "."], "h": {"id": "C1333570", "name": "C1333570#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["Consistent", "with", "conserved", "role", "for", "this", "C0079429#ent", "<e1>", "in", "the", "cochlea", ",", "the", "genetic", "mapping", "presented", "here", "support", "human", "TMIE", "as", "the", "C0079429#ent", "<e1>", "affected", "at", "C1832992#ent", "<e1>", ",", "a", "non-syndromic", "hearing", "loss", "locus", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1832992", "name": "C1832992#ent", "pos": [26, 27]}}
{"token": ["The", "C0258855#ent", "<e1>", "since", "proven", "to", "be", "identical", "to", "C0812384#ent", "<e2>", "CA", "IX"], "h": {"id": "C0258855", "name": "C0258855#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812384", "name": "C0812384#ent", "pos": [9, 10]}}
{"token": ["A", "boy", "with", "a", "suspected", "lymphoid", "malignancy", "with", "gross", "head", "C0497156#ent", "<e1>", "a", "middle", "mediastinal", "mass", "and", "rapidly", "worsening", "C0001883#ent", "<e2>"], "h": {"id": "C0497156", "name": "C0497156#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001883", "name": "C0001883#ent", "pos": [19, 20]}}
{"token": ["Acromegaly", "is", "a", "rare", "C0014130#ent", "<e1>", "characterized", "by", "C0001206#ent", "<e2>", "is", "usually", "caused", "by", "a", "pituitary", "macroadenoma"], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [8, 9]}}
{"token": ["bFGF", "was", "increased", "in", "the", "plasma", "of", "several", "subjects", "with", "C0014130#ent", "<e1>", "including", "3", "with", "untreated", "or", "persistent", "C0001206#ent", "<e2>", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0001206", "name": "C0001206#ent", "pos": [18, 19]}}
{"token": ["C0342728#ent", "<e1>", "patients", "deficient", "in", "C0295398#ent", "<e2>", "urinary", "excretion", "3-methylglutaconic", "acid", ",", "in", "contrast", "to", "the", "other", "three", "types", "of", "methylglutaconic", "acidurias", "3-hydroxyisovaleric", "acid", "excretion", "."], "h": {"id": "C0342728", "name": "C0342728#ent", "pos": [0, 1]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C0295398", "name": "C0295398#ent", "pos": [5, 6]}}
{"token": ["A", "Dictyostelium", "discoideum", "cDNA", "encoding", "an", "alpha-type", "subunit", "C0108555#ent", "<e1>", "isolated", ",", "and", "its", "cDNA", "was", "used", "to", "study", "C1836830#ent", "<e2>", "C0108555#ent", "<e1>", "the", "Dictyostelium", "life", "cycle"], "h": {"id": "C0108555", "name": "C0108555#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1836830", "name": "C1836830#ent", "pos": [19, 20]}}
{"token": ["In", "this", "pilot", "study", "we", "have", "investigated", "the", "effects", "of", "switching", "from", "C0171023#ent", "<e1>", "or", "risperidone", "treatment", "to", "low-dose", "perphenazine", "combined", "with", "C0006462#ent", "<e2>", "in", "six", "schizophrenic", "patients", "who", "had", "experienced", "weight", "gain"], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006462", "name": "C0006462#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "GSI", "and", "C3539565#ent", "<e1>", "accumulation", "within", "the", "BHP", "complex", ",", "C0018050#ent", "<e2>", ",", "and", "fillets", "of", "mature", "males", "were", "negatively", "related", "."], "h": {"id": "C3539565", "name": "C3539565#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "deficiency", "of", "Rac1", "and", "C1419228#ent", "<e1>", "GTPases", "in", "mice", "C2712370#ent", "<e2>", "actin", "assembly", "RBCs", "and", "causes", "microcytic", "anemia", "reticulocytosis", ",", "implicating", "Rac", "GTPases", "dynamic", "regulators", "of", "the", "erythrocyte", "cytoskeleton", "organization", "."], "h": {"id": "C1419228", "name": "C1419228#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [11, 12]}}
{"token": ["In", "23", "patients", "with", "uncomplicated", "C0042029#ent", "<e1>", ",", "a", "positive", "effect", "of", "the", "C0030372#ent", "<e2>", "therapy", "with", "100", "mg", "of", "ciprofloxacin", "at", "12-hour", "intervals", "was", "observed", "in", "91", "%", "of", "subjects", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030372", "name": "C0030372#ent", "pos": [13, 14]}}
{"token": ["In", "uncomplicated", "C0042029#ent", "<e1>", "women", "seen", "in", "general", "practice", "C0030372#ent", "<e2>", "course", "of", "amoxycillin", "was", "as", "effective", "as", "a", "10-day", "course", "of", "the", "same", "drug", "in", "the", "same", "dose", "."], "h": {"id": "C0042029", "name": "C0042029#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030372", "name": "C0030372#ent", "pos": [9, 10]}}
{"token": ["A", "41-year-old", "woman", "who", "presented", "with", "purpura", ",", "glomerulonephritis", "and", "C0010403#ent", "<e1>", "found", "subsequently", "to", "have", "developed", "C0034362#ent", "<e2>"], "h": {"id": "C0010403", "name": "C0010403#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034362", "name": "C0034362#ent", "pos": [17, 18]}}
{"token": ["Prenylation", "(", "or", "geranylgeranylation", ")", "of", "Rab", "GTPases", "catalysed", "by", "RGGT", "(", "C0170210#ent", "<e1>", "and", "requires", "REP", "(", "C1413394#ent", "<e2>", "."], "h": {"id": "C0170210", "name": "C0170210#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413394", "name": "C1413394#ent", "pos": [18, 19]}}
{"token": ["In", "3", "of", "the", "more", "severely", "affected", "cows", ",", "C0025517#ent", "<e1>", "a", "rapidly", "developing", "primary", "hypochloremic", ",", "secondary", "hypokalemic", "C0857122#ent", "<e2>", "metabolic", "alkalosis", "and", "hemoconcentration", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0857122", "name": "C0857122#ent", "pos": [19, 20]}}
{"token": ["Severe", "C1705610#ent", "<e1>", "most", "often", "results", "from", "left-sided", "heart", "disease", "C0155616#ent", "<e2>"], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0155616", "name": "C0155616#ent", "pos": [10, 11]}}
{"token": ["We", "describe", "a", "patient", "with", "C0011849#ent", "<e1>", "who", "had", "C0019158#ent", "<e2>", "and", "dermatitis", "in", "association", "with", "the", "use", "of", "chlorpropamide", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [9, 10]}}
{"token": ["The", "patient", "was", "admitted", "twice", "to", "our", "hospital", "and", "finally", "diagnosed", "as", "suffering", "from", "a", "C0014012#ent", "<e1>", "complicated", "by", "a", "C0023885#ent", "<e2>", "for", "which", "he", "underwent", "surgery", "."], "h": {"id": "C0014012", "name": "C0014012#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0023885", "name": "C0023885#ent", "pos": [20, 21]}}
{"token": ["C0042900#ent", "<e1>", "preceded", "the", "C0263526#ent", "<e2>"], "h": {"id": "C0042900", "name": "C0042900#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0263526", "name": "C0263526#ent", "pos": [4, 5]}}
{"token": ["Ongoing", "clinical", "research", "to", "better", "define", "the", "renal", "and", "extra-renal", "manifestations", "of", "C2936739#ent", "<e1>", "polycystic", "and", "other", "C1691228#ent", "<e2>"], "h": {"id": "C2936739", "name": "C2936739#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1691228", "name": "C1691228#ent", "pos": [17, 18]}}
{"token": ["Protective", "and", "antistress", "effects", "three", "glyprolines", "--", "C1422070#ent", "<e1>", ",", "PG", "and", "C1705010#ent", "<e2>", ",", "were", "studied", "."], "h": {"id": "C1422070", "name": "C1422070#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705010", "name": "C1705010#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "examined", "the", "alterations", "of", "H(+)-peptide", "cotransporters", "(", "PEPT1", "and", "PEPT2", ")", "and", "Na(+)-D-glucose", "cotransporters", "(", "C2699249#ent", "<e1>", "and", "SGLT2", ")", "in", "C0022661#ent", "<e2>"], "h": {"id": "C2699249", "name": "C2699249#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [26, 27]}}
{"token": ["Here", "we", "report", "that", "the", "mRNA", "of", "a", "homeobox", "gene", "C2697613#ent", "<e1>", ",", "a", "candidate", "C0079427#ent", "<e2>", "suffers", "adenosine-to-inosine", "nucleotide", "conversion", "and", "loses", "tumor-suppressive", "functions", "in", "a", "subset", "of", "human", "cancers", "."], "h": {"id": "C2697613", "name": "C2697613#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [15, 16]}}
{"token": ["The", "selective", "NK-1", "(", "C0247133#ent", "<e1>", ")", "or", "NK-2", "(", "SR-48968", ")", "antagonists", "before", "C3274161#ent", "<e2>", "challenge", "failed", "to", "reduce", "the", "allergic", "early", "airway", "responses", "."], "h": {"id": "C0247133", "name": "C0247133#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3274161", "name": "C3274161#ent", "pos": [14, 15]}}
{"token": ["The", "failure", "of", "C0106169#ent", "<e1>", "induce", "voiding", "in", "patients", "with", "C0005697#ent", "<e2>", "despite", "a", "positive", "bethanechol", "test", ",", "is", "being", "reported", "more", "frequently", "."], "h": {"id": "C0106169", "name": "C0106169#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [10, 11]}}
{"token": ["TNFR1/Fas", "engagement", "results", "in", "the", "cleavage", "of", "cytosolic", "C1332410#ent", "<e1>", "to", "truncated", "C3641819#ent", "<e2>", ",", "which", "translocates", "to", "mitochondria", "."], "h": {"id": "C1332410", "name": "C1332410#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3641819", "name": "C3641819#ent", "pos": [12, 13]}}
{"token": ["One", "of", "the", "C0127400#ent", "<e1>", "of", "interferon", "action", "a", "latent", "endoribonuclease", "C0071795#ent", "<e2>", "that", "is", "activated", "by", "(2'-5')oligoadenylates", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0071795", "name": "C0071795#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "C2936882#ent", "<e1>", "on", "the", "glycosylation", "of", "C1418186#ent", "<e2>", "studied", "in", "women", "using", "oral", "contraceptives", "in", "male-to-female", "transsexuals", "oral", "or", "transdermal", "estrogen", "treatment", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418186", "name": "C1418186#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "disrupting", "interaction", "between", "C1366514#ent", "<e1>", "and", "Hse1", "caused", "severe", "defects", "in", "C0108471#ent", "<e2>", "MVB", "formation", "."], "h": {"id": "C1366514", "name": "C1366514#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0108471", "name": "C0108471#ent", "pos": [14, 15]}}
{"token": ["Recent", "studies", "showed", "beneficial", "effects", "of", "C1705323#ent", "<e1>", "inhibition", "on", "C1418888#ent", "<e2>", "turnover", "of", "both", "IL-1beta/tumour", "necrosis", "factor", "alpha", "(", "TNFalpha", ")", "damaged", "cartilage", "and", "of", "osteoarthritic", "cartilage"], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418888", "name": "C1418888#ent", "pos": [10, 11]}}
{"token": ["We", "report", "10", "heterozygous", "mutations", "in", "the", "human", "C1337112#ent", "<e1>", "16", "probands", "with", "neonatal", "C0011849#ent", "<e2>", "."], "h": {"id": "C1337112", "name": "C1337112#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "the", "effect", "of", "acute", "cold", "exposure", "leptin", ",", "and", "the", "somatostatin", "analog", "octreotide", "(", "C1418661#ent", "<e1>", ")", "on", "thyroid", "type", "I", "D1", ")", "and", "C3273406#ent", "<e2>", "(", "D2", ")", "deiodinase", "activities", "."], "h": {"id": "C1418661", "name": "C1418661#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [26, 27]}}
{"token": ["Intracerebral", "infection", "baby", "mice", "such", "samples", "resulted", "in", "transient", "C0030552#ent", "<e1>", "and", "motion", "disturbances", "instead", "of", "the", "usually", "fatal", "C0014038#ent", "<e2>", "."], "h": {"id": "C0030552", "name": "C0030552#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [19, 20]}}
{"token": ["Instead", ",", "primase", "appears", "to", "interact", "with", "the", "C0920283#ent", "<e1>", "forming", "a", "tighter", "complex", "with", "enhanced", "C1706373#ent", "<e2>", "and", "C0920283#ent", "<e1>", "activities", "."], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [16, 17]}}
{"token": ["This", "mechanism", "is", "different", "from", "that", "deduced", "previously", "for", "C0920283#ent", "<e1>", "Complicated", "results", "were", "obtained", "using", "C1706373#ent", "<e2>", "prepared", "from", "rep3", "mutant", "cells"], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706373", "name": "C1706373#ent", "pos": [16, 17]}}
{"token": ["In", "HeLa", "cells", "recombinant", "human", "concentrative", "nucleoside", "transporter", "C3272517#ent", "<e1>", ")", "1", "or", "hCNT3", "and", "pharmacologically", "blocked", "hENT1", "and", "C3540531#ent", "<e2>", ",", "transport", "of", "10", "microM[3H]TaraC", "and", "[3H]araC", "was", "not", "detected", "."], "h": {"id": "C3272517", "name": "C3272517#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540531", "name": "C3540531#ent", "pos": [19, 20]}}
{"token": ["Using", "in", "situ", "hybridization", "immunohistochemical", "techniques", "we", "found", "that", "the", "duodenum", "expressed", "C3272517#ent", "<e1>", "and", "hCNT2", "mRNAs", "in", "enterocytes", "and", "hENT1", "and", "C3540531#ent", "<e2>", "mRNAs", "in", "crypt", "cells"], "h": {"id": "C3272517", "name": "C3272517#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540531", "name": "C3540531#ent", "pos": [22, 23]}}
{"token": ["The", "major", "activity", "is", "encoded", "by", "C1705121#ent", "<e1>", ",", "which", "is", "a", "distantly", "related", "member", "of", "the", "C1335554#ent", "<e2>"], "h": {"id": "C1705121", "name": "C1705121#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [17, 18]}}
{"token": ["The", "results", "are", "discussed", "with", "reference", "to", "the", "relationship", "between", "the", "C1416886#ent", "<e1>", "receptor-stimulated", "increase", "in", "cAMP", "formation", "and", "the", "induction", "of", "C0013384#ent", "<e2>", "in", "humans", "by", "these", "anti-parkinsonian", "drugs"], "h": {"id": "C1416886", "name": "C1416886#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [22, 23]}}
{"token": ["The", "role", "of", "C1416886#ent", "<e1>", "and", "D2", "dopaminergic", "receptors", "the", "occurrence", "of", "C0013384#ent", "<e2>", ",", "particularly", "that", "of", "tics", ",", "is", "discussed", "."], "h": {"id": "C1416886", "name": "C1416886#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [12, 13]}}
{"token": ["To", "determine", "whether", "antenatal", "exposure", "to", "terbutaline", "C2712370#ent", "<e1>", "the", "lung", "C0178695#ent", "<e2>", "concentration", "or", "lung", "water", "content", "at", "birth", "in", "preterm", "rabbit", "pups", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0178695", "name": "C0178695#ent", "pos": [11, 12]}}
{"token": ["Wolfram", "syndrome", "C2699843#ent", "<e1>", ")", "is", "an", "autosomal", "recessive", "neurodegenerative", "disorder", "by", "early", "onset", "diabetes", "mellitus", "progressive", "C0338508#ent", "<e2>", "the", "first", "decade", "of", "life", "."], "h": {"id": "C2699843", "name": "C2699843#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0338508", "name": "C0338508#ent", "pos": [17, 18]}}
{"token": ["We", "investigated", "whether", "NO", "synthase", "C0669372#ent", "<e1>", ")", "inhibition", "modulates", "basal", "sympathetic", "nerve", "discharge", "(", "C1822796#ent", "<e2>", ")", "in", "baroreceptor-innervated", "and", "-denervated", ",", "chloralose-anesthetized", "Sprague-Dawley", "rats"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1822796", "name": "C1822796#ent", "pos": [15, 16]}}
{"token": ["Adverse", "effects", "epidurally", "administered", "C3541403#ent", "<e1>", "urinary", "retention", "hypotension", ",", "numbness", ",", "C0427055#ent", "<e2>", "tachyphylaxis", ",", "and", ",", "rarely", ",", "systemic", "toxicity"], "h": {"id": "C3541403", "name": "C3541403#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [12, 13]}}
{"token": ["A", "behavioral", "test", "C0007758#ent", "<e1>", "was", "performed", "on", "pigeons", "given", "lead", "by", "C1836205#ent", "<e2>", "intubation", "or", "i.m", "."], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1836205", "name": "C1836205#ent", "pos": [12, 13]}}
{"token": ["This", "development", "occurred", "first", "for", "C3275124#ent", "<e1>", "more", "recently", "for", "primary", "diseases", "the", "C0771711#ent", "<e2>", "."], "h": {"id": "C3275124", "name": "C3275124#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [13, 14]}}
{"token": ["Over", "the", "last", "3", "years", "at", "our", "hospital", ",", "two", "patients", "with", "the", "acquired", "immunodeficiency", "syndrome", "acute", "pancreatic", "C3275124#ent", "<e1>", "demonstrated", "at", "autopsy", "to", "be", "secondary", "to", "cytomegalovirus", "infection", "the", "C0771711#ent", "<e2>", ",", "have", "been", "evaluated", "."], "h": {"id": "C3275124", "name": "C3275124#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [30, 31]}}
{"token": ["This", "was", "accomplished", "by", "an", "increase", "in", "cholesteryl", "esterification", "measured", "by", "C1258847#ent", "<e1>", "but", "no", "change", "in", "C1334064#ent", "<e2>", "activity", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334064", "name": "C1334064#ent", "pos": [17, 18]}}
{"token": ["In", "arthritic", "rat", "stomachs", ",", "cyclooxygenase", "(COX)-2", "was", "also", "up-regulated", ",", "where", "COX-2", "C0003015#ent", "<e1>", "as", "rofecoxib", "or", "C0538927#ent", "<e2>", "provoked", "gross", "lesions", "although", "they", "caused", "no", "damage", "in", "normal", "rats", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "it", "is", "reported", "for", "the", "first", "time", "that", "C0290149#ent", "<e1>", "is", "also", "implicated", "in", "C1442864#ent", "<e2>", "DN", ")", "."], "h": {"id": "C0290149", "name": "C0290149#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [16, 17]}}
{"token": ["Variant", "genotypes", "of", "uridine", "diphosphate", "glucuronsyltransferase", "isoenzyme", "1A6", "C1421330#ent", "<e1>", ")", "associated", "with", "decreased", "metabolic", "activity", "been", "associated", "with", "enhanced", "protective", "effect", "C0004057#ent", "<e2>", "on", "the", "development", "of", "colorectal", "adenomas"], "h": {"id": "C1421330", "name": "C1421330#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [22, 23]}}
{"token": ["The", "FA-6", "cells", "now", "established", "are", "the", "first", "cells", "of", "pancreatic", "cancer", "associated", "with", "C0149911#ent", "<e1>", "producing", "both", "PTH-like", "and", "TGF-alpha", "activities", "along", "with", "C0106893#ent", "<e2>"], "h": {"id": "C0149911", "name": "C0149911#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0106893", "name": "C0106893#ent", "pos": [24, 25]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "expression", "and", "production", "of", "C0013765#ent", "<e1>", "in", "the", "lung", "in", "newborn", "rats", "with", "C3542407#ent", "<e2>", "during", "mechanical", "ventilation"], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [22, 23]}}
{"token": ["Pre-treatment", "of", "C0399440#ent", "<e1>", "dramatically", "protected", "glycerol-induced", "C0022660#ent", "<e2>", "rats", "against", "death", ",", "and", "prevented", "deterioration", "of", "biochemical", "parameters", "for", "renal", "function"], "h": {"id": "C0399440", "name": "C0399440#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [7, 8]}}
{"token": ["There", "is", "strong", "evidence", "that", "NCA-50", "is", "bound", "to", "a", "C1418563#ent", "<e1>", "via", "an", "amide", "linkage", "ethanolamine", "at", "C2917660#ent", "<e2>", "287", ",", "which", "has", "replaced", "the", "last", "24", "amino", "acids"], "h": {"id": "C1418563", "name": "C1418563#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [18, 19]}}
{"token": ["C0015732#ent", "<e1>", "is", "one", "of", "the", "most", "common", "C0008679#ent", "<e2>", "women", "and", "is", "found", "in", "17", "-", "60", "%", "of", "the", "whole", "population"], "h": {"id": "C0015732", "name": "C0015732#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [8, 9]}}
{"token": ["One", "laboratory", "has", "reported", "the", "in", "vivo", "tumour", "inhibitory", "effect", "of", "phosphorothioate", "antisense", "oligonucleotide", "directed", "against", "the", "C0808901#ent", "<e1>", "part", "of", "C1860425#ent", "<e2>", "when", "injected", "intratumourally", "."], "h": {"id": "C0808901", "name": "C0808901#ent", "pos": [17, 18]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1860425", "name": "C1860425#ent", "pos": [21, 22]}}
{"token": ["We", "present", "data", "here", "to", "show", "that", "intestinal", "mast", "cell", "hyperplasia", "induced", "by", "C0018889#ent", "<e1>", "also", "dependent", "upon", "the", "production", "of", "stem", "cell", "factor", "C1366480#ent", "<e2>", ")", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366480", "name": "C1366480#ent", "pos": [24, 25]}}
{"token": ["It", "appeared", "to", "be", "possible", "to", "determine", "alkaloid", "halides", "C0036079#ent", "<e1>", "hexachlorophene", "and", "C0066282#ent", "<e2>", "previous", "clean-up", "of", "the", "cream", "samples", "."], "h": {"id": "C0036079", "name": "C0036079#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0066282", "name": "C0066282#ent", "pos": [13, 14]}}
{"token": ["C0071649#ent", "<e1>", "inhibited", "the", "transport", "of", "C0073983#ent", "<e2>", "and", "ferulic", "acids", ",", "suggesting", "tea", "polyphenols", "be", "substrates", "of", "MCT", "."], "h": {"id": "C0071649", "name": "C0071649#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0073983", "name": "C0073983#ent", "pos": [6, 7]}}
{"token": ["Diffuse", ",", "concentric", "thickening", "seen", "with", "C0008311#ent", "<e1>", "diffuse", ",", "eccentric", "thickening", "was", "associated", "with", "oriental", "cholangiohepatitis", "C0566602#ent", "<e2>"], "h": {"id": "C0008311", "name": "C0008311#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [17, 18]}}
{"token": ["Drug-induced", "cholestasis", "may", "be", "due", "to", "impairment", "of", "hepatocellular", "bile", "secretion", "pure", "cholestasis", "or", "cholestatic", "hepatitis", ",", "obstruction", "of", "ductules", "(", "C0008311#ent", "<e1>", ")", "or", "interlobular", "ducts", "cholangitis", ")", ",", "or", "extrahepatic", "obstruction", "C0566602#ent", "<e2>", "."], "h": {"id": "C0008311", "name": "C0008311#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [33, 34]}}
{"token": ["IgG4", "C0008311#ent", "<e1>", "should", "therefore", "be", "differentiated", "from", "C0566602#ent", "<e2>", "on", "clinics", ",", "radiological", "and", "biological", "markers"], "h": {"id": "C0008311", "name": "C0008311#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [8, 9]}}
{"token": ["Movement", "disorders", "adversely", "affected", "by", "C0001975#ent", "<e1>", ",", "drugs", ",", "lack", "of", "sleep", ",", "C0034362#ent", "<e2>", ",", "stress", ",", "age", ",", "and", "trauma", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034362", "name": "C0034362#ent", "pos": [14, 15]}}
{"token": ["C0036734#ent", "<e1>", "to", "the", "most", "studied", "class", "of", "C3540759#ent", "<e2>", "and", "are", "a", "primary", "target", "in", "the", "drug", "development", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540759", "name": "C3540759#ent", "pos": [8, 9]}}
{"token": ["These", "observations", "provide", "clues", "for", "the", "design", "of", "more", "specific", "inhibitors", "and", "show", "how", "ST3", "can", "accommodate", "a", "C0597221#ent", "<e1>", "a", "(", "d", ",", "l", ")", "C0030956#ent", "<e2>", "."], "h": {"id": "C0597221", "name": "C0597221#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [26, 27]}}
{"token": ["This", "indicates", "that", "consumption", "of", "red", "wine", "two", "separate", "mechanisms", "in", "elevation", "of", "plasma", "C1705621#ent", "<e1>", "values", "and", "both", "C0031428#ent", "<e2>", "plasma", "urate", "to", "that", "effect", "."], "h": {"id": "C1705621", "name": "C1705621#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [19, 20]}}
{"token": ["Increased", "synthesis", "of", "L-ornithine", "by", "C1412515#ent", "<e1>", "may", "also", "contribute", "to", "airway", "remodelling", "in", "these", "C0029896#ent", "<e2>", "."], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [15, 16]}}
{"token": ["These", "findings", "suggest", "a", "new", "alternative", "strategy", "for", "controlling", "the", "deleterious", "roles", "of", "these", "C3494976#ent", "<e1>", "in", "breast", "cancer", "inhibiting", "their", "upstream", "coregulator", "C1334868#ent", "<e2>", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334868", "name": "C1334868#ent", "pos": [23, 24]}}
{"token": ["Because", "these", "agents", "lead", "to", "the", "production", "of", "symptoms", "in", "patients", "that", "are", "C0004096#ent", "<e1>", ",", "the", "use", "of", "leukotriene", "enzyme", "inhibitors", "particularly", "C0298130#ent", "<e2>", ",", "and", "zafirlukasts", "seem", "appropriate", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0298130", "name": "C0298130#ent", "pos": [23, 24]}}
{"token": ["The", "C0027849#ent", "<e1>", "was", "effectively", "treated", "with", "C0010976#ent", "<e2>", "the", "patient", "recovered", "on", "both", "occasions", "."], "h": {"id": "C0027849", "name": "C0027849#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0010976", "name": "C0010976#ent", "pos": [7, 8]}}
{"token": ["Moreover", ",", "we", "demonstrated", "that", "C1421350#ent", "<e1>", "specifically", "inhibits", "C2827383#ent", "<e2>", "by", "blocking", "phosphorylation", "of", "C2827383#ent", "<e2>", "Thr", "389", "."], "h": {"id": "C1421350", "name": "C1421350#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [9, 10]}}
{"token": ["In", "the", "immunosuppressive", "treatment", "C0024143#ent", "<e1>", "insertion", "of", "a", "C0521530#ent", "<e2>", "rituximab", "combined", "with", "cyclophosphamide", "achieves", "a", "therapeutically", "important", "and", "lasting", "deletion", "of", "the", "lymphocyte", "clone", "for", "autoimmunity", "."], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0521530", "name": "C0521530#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "if", "the", "microorganism", "was", "allowed", "to", "grow", "on", "a", "minimal", "medium", ",", "several", "soluble", "C0030940#ent", "<e1>", "were", "extracted", ",", "among", "them", "the", "TGase-activating", "protease", "(", "C1707163#ent", "<e2>", ")", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1707163", "name": "C1707163#ent", "pos": [28, 29]}}
{"token": ["However", ",", "the", "VEGF", "hybridization", "signal", "was", "markedly", "less", "in", "adult", "C0268731#ent", "<e1>", "than", "those", "for", "neuropilin-1", "and", "C1705712#ent", "<e2>", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705712", "name": "C1705712#ent", "pos": [18, 19]}}
{"token": ["TAO2", "is", "a", "MAP3K", "kinase", "that", "activates", "the", "MAP2Ks", "MEK3", "C1334475#ent", "<e1>", "to", "activate", "C1705633#ent", "<e2>", "MAPKs", "."], "h": {"id": "C1334475", "name": "C1334475#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [14, 15]}}
{"token": ["We", "administered", "the", "C0593802#ent", "<e1>", "fadrozole", "to", "16", "girls", "with", "C0342549#ent", "<e2>", "to", "the", "McCune-Albright", "syndrome"], "h": {"id": "C0593802", "name": "C0593802#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0342549", "name": "C0342549#ent", "pos": [10, 11]}}
{"token": ["Activation", "of", "the", "C3853563#ent", "<e1>", "but", "not", "the", "C1537502#ent", "<e2>", "or", "N-ras", "genes", "has", "been", "found", "in", "mammary", "gland", "carcinomas", "induced", "in", "female", "rats", "by", "a", "single", "dose", "methylnitrosourea", "(", "MNU", ")", "."], "h": {"id": "C3853563", "name": "C3853563#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [8, 9]}}
{"token": ["Upon", "TWEAK", "stimulation", ",", "IkappaBalpha", "is", "rapidly", "phosphorylated", ",", "generating", "NF-kappaB", "DNA-binding", "complexes", "containing", "C1423613#ent", "<e1>", "and", "RelA", "in", "a", "manner", "dependent", "on", "the", "C0663914#ent", "<e2>"], "h": {"id": "C1423613", "name": "C1423613#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0663914", "name": "C0663914#ent", "pos": [24, 25]}}
{"token": ["C3540592#ent", "<e1>", "and", "proteasome", "C2", "subunit", "proteins", "as", "insulin", "increased", ",", "with", "C1540067#ent", "<e2>", "expression", "largely", "unchanged", "."], "h": {"id": "C3540592", "name": "C3540592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1540067", "name": "C1540067#ent", "pos": [12, 13]}}
{"token": ["C0003864#ent", "<e1>", "the", "only", "C3899281#ent", "<e2>", "which", "the", "specific", "cause", "is", "known", "and", "can", "be", "cured", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C3899281", "name": "C3899281#ent", "pos": [4, 5]}}
{"token": ["A23187", ",", "a", "C0022022#ent", "<e1>", "reduced", "DNA", "synthesis", "and", "C0000546#ent", "<e2>", "rapidly", "increased", "[Ca2+]i", "measured", "with", "the", "Fura", "II", "technique"], "h": {"id": "C0022022", "name": "C0022022#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000546", "name": "C0000546#ent", "pos": [9, 10]}}
{"token": ["We", "report", "eight", "children", "with", "autoimmune", "cytopenias", "autoimmune", "haemolytic", "anaemia", "C0242584#ent", "<e1>", "autoimmune", "neutropenia", "complicating", "immune", "deficiency", "states", "common", "variable", "immunodeficiency", ",", "C1421478#ent", "<e2>", "autoimmune", "lymphoproliferative", "syndrome", "combined", "immunodeficiency", "treated", "with", "1", "and", "3", "courses", "of", "rituximab", "(", "anti-CD20", ")", "."], "h": {"id": "C0242584", "name": "C0242584#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1421478", "name": "C1421478#ent", "pos": [22, 23]}}
{"token": ["The", "cDNA", "and", "the", "C0079429#ent", "<e1>", "for", "the", "C3811771#ent", "<e2>", "cloned", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3811771", "name": "C3811771#ent", "pos": [8, 9]}}
{"token": ["Treatment", ",", "as", "described", ",", "with", "topical", "L-betaxolol", "completely", "blunted", "the", "effects", "upon", "C0124604#ent", "<e1>", "immunoreactivity", "and", "caused", "a", "significant", "reversal", "of", "the", "C0599295#ent", "<e2>", "changes", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0599295", "name": "C0599295#ent", "pos": [23, 24]}}
{"token": ["Diet", "induced", "C0854110#ent", "<e1>", "Psammomys", "and", "streptozotocin", "induced", "low", "C0854110#ent", "<e1>", "rats", ",", "modulated", "[3H]oleate", "binding", "in", "the", "same", "manner", "."], "h": {"id": "C0854110", "name": "C0854110#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0854110", "name": "C0854110#ent", "pos": [2, 3]}}
{"token": ["No", "significant", "in", "tissue", "level", "of", "C0214788#ent", "<e1>", "observed", "during", "time", "course", "after", "C0086154#ent", "<e2>", "administration", "."], "h": {"id": "C0214788", "name": "C0214788#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086154", "name": "C0086154#ent", "pos": [13, 14]}}
{"token": ["Direct", "C1705556#ent", "<e1>", "binding", "measurements", "showed", "that", "C1414349#ent", "<e2>", "had", "a", "higher", "binding", "affinity", "for", "ADP", "than", "C1705556#ent", "<e1>", ",", "resulting", "in", "a", "limited", "hydrolysis", "and", "procession", "along", "the", "RNA", "in", "the", "helicase", "assay"], "h": {"id": "C1414349", "name": "C1414349#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [1, 2]}}
{"token": ["C0004259#ent", "<e1>", "did", "not", "inhibit", "the", "contractions", "to", "C1417815#ent", "<e2>", ",", "PYY", "and", "[Leu31,Pro34]NPY", "but", "significantly", "affected", "those", "to", "NPY(13", "-", "36", ")", ",", "[D-Trp32]NPY", ",", "rPP", "and", "hPP", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [8, 9]}}
{"token": ["C0699918#ent", "<e1>", "concentrations", "did", "not", "correlate", "with", "alcohol", "consumption", "C0011849#ent", "<e2>", "diabetes", "therapy"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["We", "examined", "the", "predictive", "value", "survival", "of", "various", "clinical", "and", "laboratory", "parameters", ",", "including", "C1366489#ent", "<e1>", "PSA", ")", ",", "in", "HRPC", "patients", "treated", "with", "C0038880#ent", "<e2>", "."], "h": {"id": "C1366489", "name": "C1366489#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [24, 25]}}
{"token": ["To", "see", "relations", "between", "DHP-CCB", "and", "episodes", "of", "C0427055#ent", "<e1>", "patients", "with", "C0221043#ent", "<e2>", "we", "surveyed", "retrospectively", "the", "history", "of", "C0427055#ent", "<e1>", "anti-hypertensive", "drugs", "14", "consecutive", "cases", "with", "C0221043#ent", "<e2>", "our", "institute", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0221043", "name": "C0221043#ent", "pos": [12, 13]}}
{"token": ["C4023510#ent", "<e1>", "ES", ")", "may", "complicate", "the", "clinical", "course", "patients", "with", "C0038454#ent", "<e2>"], "h": {"id": "C4023510", "name": "C4023510#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [11, 12]}}
{"token": ["We", "have", "recently", "shown", "that", "phosphoprotein", "phosphatase", "PP", ")", "activity", "is", "essential", "for", "C1514550#ent", "<e1>", "transcription", "of", "the", "human", "C1706114#ent", "<e2>", "(", "hCYP17", ")", "gene", "in", "H295R", "adrenocortical", "cells", "."], "h": {"id": "C1514550", "name": "C1514550#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706114", "name": "C1706114#ent", "pos": [19, 20]}}
{"token": ["The", "above", "sampling", "method", "moderately", "adequate", "method", "for", "trace", "element", "sampling", "C0009137#ent", "<e1>", "as", "well", "as", "C3541397#ent", "<e2>", "fired", "power", "plants", "for", "Hg", "."], "h": {"id": "C0009137", "name": "C0009137#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3541397", "name": "C3541397#ent", "pos": [16, 17]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "describe", "a", "C0205721#ent", "<e1>", "outbreak", "of", "influenza", "during", "a", "period", "without", "C0856238#ent", "<e2>", "in", "the", "community", "."], "h": {"id": "C0205721", "name": "C0205721#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0856238", "name": "C0856238#ent", "pos": [18, 19]}}
{"token": ["C0528166#ent", "<e1>", "is", "a", "selective", "C0162754#ent", "<e2>", "'", "triptan", "'", ")", "."], "h": {"id": "C0528166", "name": "C0528166#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162754", "name": "C0162754#ent", "pos": [5, 6]}}
{"token": ["Orally", "dosed", "itraconazole", "(", "ITZ", ")", "compositions", ",", "formed", "by", "SFL", ",", "produce", "higher", "serum", "levels", "of", "the", "C1254351#ent", "<e1>", "compared", "to", "the", "commercial", "product", "C0699614#ent", "<e2>", "oral", "solution"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0699614", "name": "C0699614#ent", "pos": [25, 26]}}
{"token": ["C0379199#ent", "<e1>", "is", "thus", "an", "effective", ",", "flexible", ",", "and", "well-tolerated", "C0012544#ent", "<e2>", "that", "can", "meet", "the", "varying", "requirements", "of", "patients", "with", "MBD", "."], "h": {"id": "C0379199", "name": "C0379199#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [11, 12]}}
{"token": ["Immunoblot", "experiments", "anti-(MAP", "kinase", ")", "and", "anti-phosphotyrosine", "antibodies", "showed", "changes", "in", "both", "electrophoretic", "mobility", "C0085536#ent", "<e1>", "content", "of", "40", "and", "44", "kDa", "C0022173#ent", "<e2>", "suggesting", "that", "prolactin", "affects", "these", "isoforms", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [22, 23]}}
{"token": ["We", "found", "that", "vanadate", ",", "an", "inhibitor", "of", "C0085536#ent", "<e1>", "induced", "the", "expression", "of", "two", "COX", "C0022173#ent", "<e2>", "mRNAs", "in", "human", "umbilical", "vein", "endothelial", "cells", "HUVEC", ")", "in", "a", "time-", "and", "dose-dependent", "manner", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [16, 17]}}
{"token": ["C3826857#ent", "<e1>", "analysis", "identified", "a", "C0947622#ent", "<e2>", "chromosome", "17", "Lith3", ")", "."], "h": {"id": "C3826857", "name": "C3826857#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [5, 6]}}
{"token": ["C3826857#ent", "<e1>", "analyses", "were", "performed", "using", "C0947622#ent", "<e2>", "gallstone", "absence/presence", "as", "phenotypes", ";", "various", "models", "were", "explored", "for", "genome", "scans"], "h": {"id": "C3826857", "name": "C3826857#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [6, 7]}}
{"token": ["C3826857#ent", "<e1>", "mapping", "detected", "one", "significant", "new", "C0947622#ent", "<e2>", "susceptibility", "(", "Lith", ")", "locus", "on", "Chromosome", "13", "Lith15", ")", "."], "h": {"id": "C3826857", "name": "C3826857#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0947622", "name": "C0947622#ent", "pos": [7, 8]}}
{"token": ["The", "pool", "of", "cyclins", "B", "after", "CDK1", "inactivation", "in", "the", "presence", "of", "C0246694#ent", "<e1>", "is", "mitotically", "inert", ",", "while", "exogenous", "or", "newly", "synthesized", "C1332695#ent", "<e2>", "CDK1", "."], "h": {"id": "C0246694", "name": "C0246694#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332695", "name": "C1332695#ent", "pos": [23, 24]}}
{"token": ["C0246694#ent", "<e1>", "abrogated", "the", "GA-induced", "decrease", "of", "Cdc2", "and", "C1332695#ent", "<e2>", "that", "these", "proteins", "were", "degraded", "by", "proteasomes", "."], "h": {"id": "C0246694", "name": "C0246694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332695", "name": "C1332695#ent", "pos": [9, 10]}}
{"token": ["After", "transfection", "of", "the", "mutant", "C1336679#ent", "<e1>", "cDNAs", "into", "Cos-7", "cells", "we", "show", "that", "the", "C1564139#ent", "<e2>", "normally", "synthesized", ",", "processed", ",", "and", "incorporated", "into", "the", "membrane", "bilayer", "Western", "blotting", "a", "specific", "receptor", "antibody"], "h": {"id": "C1336679", "name": "C1336679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1564139", "name": "C1564139#ent", "pos": [15, 16]}}
{"token": ["C0030779#ent", "<e1>", "consisting", "of", "3-HB", "and", "3-hydroxyvalerate", "(", "3-HV", ")", "could", "be", "produced", "by", "both", "C1883559#ent", "<e2>", "recombinant", "A.", "hydrophila", "4AK4", "and", "the", "latter", "could", "produce", "C0030779#ent", "<e1>", "with", "more", "3-HB", "monomer", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [0, 1]}}
{"token": ["We", "show", "that", "both", "DNA-PK", "and", "C0004135#ent", "<e1>", "phosphorylate", "RPA32", "on", "C2985427#ent", "<e2>", "in", "vitro"], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2985427", "name": "C2985427#ent", "pos": [11, 12]}}
{"token": ["We", "have", "now", "characterized", "the", "human", "C0079429#ent", "<e1>", "encoding", "kidney", "11", "beta", "HSD", "(", "C1857550#ent", "<e2>", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1857550", "name": "C1857550#ent", "pos": [14, 15]}}
{"token": ["The", "younger", "brother", "C1426204#ent", "<e1>", "cryptorchidism", ",", "inguinal", "herniae", "and", "hypohidrosis", ",", "while", "the", "older", "brother", "C0162361#ent", "<e2>", "juvenile", "autoimmune", "thyroiditis", "hypolacrimation", ",", "photophobia", ",", "and", "optic", "atrophy"], "h": {"id": "C1426204", "name": "C1426204#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162361", "name": "C0162361#ent", "pos": [16, 17]}}
{"token": ["C0907533#ent", "<e1>", "NOS", ")", "genes", "(", "C1417759#ent", "<e2>", ",", "NOS2A", ",", "and", "NOS3", ")", "may", "create", "excess", "nitric", "oxide", "contributes", "to", "neurodegeneration", "in", "Parkinson's", "disease", "PD", ")", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417759", "name": "C1417759#ent", "pos": [6, 7]}}
{"token": ["The", "effects", "of", "two", "central", "nervous", "system", "CNS", ")", "C0003289#ent", "<e1>", "drugs", "ethanol", "and", "C0037567#ent", "<e2>", "compared", "using", "two", "pairs", "of", "mouse", "lines", "had", "been", "selected", "from", "a", "heterogeneous", "stock", "for", "differential", "sensitivity", "to", "ethanol", "."], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [9, 10]}, "relation": "therapeutic_class_of", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [14, 15]}}
{"token": ["We", "have", "devised", "a", "method", "for", "the", "parallel", "determination", "of", "C0008407#ent", "<e1>", "CAT", ")", "and", "C1413400#ent", "<e2>", "mCh-R", ")", "in", "the", "same", "brain", "tissue"], "h": {"id": "C0008407", "name": "C0008407#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413400", "name": "C1413400#ent", "pos": [15, 16]}}
{"token": ["The", "influences", "of", "mass", "transfer", "adsorption-desorption", "kinetics", "on", "the", "binding", "of", "staphylococcal", "enterotoxin", "B", "C3815268#ent", "<e1>", ")", "to", "an", "affinity", "resin", "the", "C0030956#ent", "<e2>", "Tyr-Tyr-Trp-Leu-His-His", "(", "YYWLHH", ")", "have", "been", "studied", "."], "h": {"id": "C3815268", "name": "C3815268#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [22, 23]}}
{"token": ["C0221261#ent", "<e1>", "is", "a", "well-recognized", "clinical", "sign", "C0162316#ent", "<e2>", "either", "with", "or", "without", "anemia", "."], "h": {"id": "C0221261", "name": "C0221261#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [7, 8]}}
{"token": ["Perhaps", "the", "best", "known", "example", "of", "this", "is", "C0221261#ent", "<e1>", "as", "a", "sequale", "of", "C0162316#ent", "<e2>", "anemia", "."], "h": {"id": "C0221261", "name": "C0221261#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162316", "name": "C0162316#ent", "pos": [14, 15]}}
{"token": ["Of", "the", "15,584", "patients", "with", "an", "index", "sildenafil", "claim", ",", "10,863", "had", "a", "second", "C2923059#ent", "<e1>", "prescription", "(", "10,137", "for", "sildenafil", ",", "726", "for", "C0971579#ent", "<e2>", "or", "tadalafil", ")", "."], "h": {"id": "C2923059", "name": "C2923059#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0971579", "name": "C0971579#ent", "pos": [24, 25]}}
{"token": ["The", "authors", "report", "a", "case", "of", "hyperkeratosis", "C0022596#ent", "<e1>", "with", "periodontosis", "(", "C0030360#ent", "<e2>", "in", "a", "five", "year", "old", "male", "patient", "."], "h": {"id": "C0022596", "name": "C0022596#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C0030360", "name": "C0030360#ent", "pos": [12, 13]}}
{"token": ["A", "correlation", "between", "the", "induction", "by", "C0011777#ent", "<e1>", "of", "the", "GS-mRNA", "level", "and", "the", "GS", "biological", "activity", "a", "C1710463#ent", "<e2>", "GS", "expression", "by", "the", "aforesaid", "hormone", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "C0085300#ent", "<e1>", "overrides", "the", "C0026249#ent", "<e2>", "dependence", "of", "S-phase", "entry", "by", "deregulating", "Rb", "phosphorylation", ",", "E2F-pocket", "protein", "interactions", ",", "and", "ultimately", "cyclin", "A-cdk2", "activity", "."], "h": {"id": "C0085300", "name": "C0085300#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [6, 7]}}
{"token": ["However", ",", "the", "relative", "potencies", "of", "the", "mono-ortho-substituted", "PCBs", "were", "higher", "for", "C0162533#ent", "<e1>", "accumulation", "than", "for", "hepatic", "C0919425#ent", "<e2>", "and", "CYP1A2", "induction", "."], "h": {"id": "C0162533", "name": "C0162533#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [18, 19]}}
{"token": ["O2.-", "formation", "induced", "by", "Pam3Cys-Ser-(Lys)4", "and", "C3489445#ent", "<e1>", "was", "enhanced", "by", "cytochalasin", "B", "by", "a", "phorbol", "ester", "by", "a", "C0113519#ent", "<e2>"], "h": {"id": "C3489445", "name": "C3489445#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0113519", "name": "C0113519#ent", "pos": [19, 20]}}
{"token": ["The", "metabolism", "of", "C0541218#ent", "<e1>", "investigated", "in", "rat", "C0669372#ent", "<e2>", "."], "h": {"id": "C0541218", "name": "C0541218#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}}
{"token": ["The", "amniotic", "fluid", "volume", "of", "the", "C1332416#ent", "<e1>", "twin", "became", "normal", "and", "the", "C0020305#ent", "<e2>", "spontaneously", "in", "utero", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020305", "name": "C0020305#ent", "pos": [13, 14]}}
{"token": ["These", "modulations", "of", "gene", "expression", "clinostat", "culture", "were", "blocked", "by", "a", "protein", "kinase", "A", "PKA", ")", "inhibitor", ",", "C0082782#ent", "<e1>", ",", "but", "not", "by", "a", "C3536910#ent", "<e2>", "indomethacin", "."], "h": {"id": "C0082782", "name": "C0082782#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3536910", "name": "C3536910#ent", "pos": [25, 26]}}
{"token": ["Captopril", "was", "administered", "to", "indomethacin-treated", "dogs", "to", "assess", "the", "role", "of", "C2698414#ent", "<e1>", "independent", "of", "prostaglandins", "(", "PGs", ")", "in", "the", "haemodynamic", "response", "C0020452#ent", "<e2>", "."], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020452", "name": "C0020452#ent", "pos": [23, 24]}}
{"token": ["The", "influence", "that", "previous", "clinical", "expressions", "C0004153#ent", "<e1>", "have", "on", "evolution", "and", "early", "mortality", "in", "patients", "with", "C0948008#ent", "<e2>", "not", "known", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0948008", "name": "C0948008#ent", "pos": [17, 18]}}
{"token": ["The", "occurrence", "of", "urinary", "stones", "significantly", "associated", "with", "of", "gallstones", ",", "high", "blood", "pressure", "C0024031#ent", "<e1>", ",", "arthritis", "and", "C0018099#ent", "<e2>", "but", "not", "with", "that", "of", "peptic", "ulcer", "diabetes", ",", "thyroid", "disease", "bronchitis", "."], "h": {"id": "C0024031", "name": "C0024031#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [19, 20]}}
{"token": ["As", "an", "example", ",", "the", "analysis", "of", "a", "segment", "of", "the", "gene", "for", "C1421374#ent", "<e1>", "patients", "with", "C0162566#ent", "<e2>", "described", "."], "h": {"id": "C1421374", "name": "C1421374#ent", "pos": [13, 14]}, "relation": "gene_associated_with_disease", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [17, 18]}}
{"token": ["Subnormal", "activity", "C1421374#ent", "<e1>", "responsible", "for", "the", "derangement", "of", "porphyrin", "biosynthesis", "both", "sporadic", "and", "C0162566#ent", "<e2>", "but", "the", "enzymatic", "defect", "is", "not", "clinically", "expressed", "in", "the", "absence", "of", "hepatic", "siderosis"], "h": {"id": "C1421374", "name": "C1421374#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0162566", "name": "C0162566#ent", "pos": [14, 15]}}
{"token": ["In", "patients", "with", "C0007785#ent", "<e1>", "of", "noncardiac", "origin", ",", "C0004057#ent", "<e2>", "and", "ticlopidine", "reduce", "the", "risk", "of", "stroke", ",", "but", "the", "benefit", "is", "modest", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [9, 10]}}
{"token": ["We", "present", "2", "cases", "of", "C0010481#ent", "<e1>", "secondary", "adrenal", "insufficiency", "concomitant", "use", "of", "ritonavir", "and", "inhaled", "corticosteroids", "children", "with", "C0019693#ent", "<e2>"], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [19, 20]}}
{"token": ["Account", "should", "also", "be", "taken", "of", "pseudo-asthmas", ",", "i.e.", "other", "C0679247#ent", "<e1>", "accompanying", "the", "C0013404#ent", "<e2>"], "h": {"id": "C0679247", "name": "C0679247#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [14, 15]}}
{"token": ["C1412332#ent", "<e1>", "was", "in", "the", "normal", "range", "both", "C0733482#ent", "<e2>", "alone", "and", "C0733482#ent", "<e2>", "plus", "CSA", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0733482", "name": "C0733482#ent", "pos": [8, 9]}}
{"token": ["The", "production", "of", "C0009450#ent", "<e1>", "human", "immunodeficiency", "virus", "type", "1", "dependent", "on", "the", "accurate", "cleavage", "of", "its", "C0017346#ent", "<e2>", "and", "Gag/Pol", "precursors", "by", "a", "virally", "encoded", "protease", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [17, 18]}}
{"token": ["The", "intracellular", "location", "of", "C0034340#ent", "<e1>", "EC", "6.4.1.1", ",", "citrate", "synthase", "EC", "4.1.3.7", ")", "and", "C0085889#ent", "<e2>", "EC", "1.1.1.35", ")", "in", "rat", "mammary", "gland", "investigated", "by", "using", "a", "fractional-extraction", "technique"], "h": {"id": "C0034340", "name": "C0034340#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085889", "name": "C0085889#ent", "pos": [15, 16]}}
{"token": ["The", "increased", "selectivity", "of", "ShK-Dap22", "is", "achieved", "by", "strong", "interactions", "of", "C1412739#ent", "<e1>", "with", "His404", "and", "Asp386", "on", "C1416546#ent", "<e2>", ",", "with", "only", "weak", "interactions", "between", "the", "channel", "pore", "the", "toxin", "."], "h": {"id": "C1412739", "name": "C1412739#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416546", "name": "C1416546#ent", "pos": [18, 19]}}
{"token": ["There", "are", "2", "types", "of", "NDM", ":", "C0158981#ent", "<e1>", "PNDM", ")", "and", "C0342273#ent", "<e2>", "TNDM", ")", "."], "h": {"id": "C0158981", "name": "C0158981#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0342273", "name": "C0342273#ent", "pos": [12, 13]}}
{"token": ["FBN1", "at", "15q21.1", "was", "found", "to", "cause", "Marfan", "syndrome", "1991", ",", "and", "in", "2004", "C1705614#ent", "<e1>", "at", "3p24.1", "was", "newly", "identified", "as", "the", "C0024796#ent", "<e2>"], "h": {"id": "C1705614", "name": "C1705614#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [23, 24]}}
{"token": ["To", "explore", "the", "function", "of", "the", "C1415619#ent", "<e1>", "we", "isolated", "a", "C0017361#ent", "<e2>", "temperature-sensitive", "mutation", "RHO1", ",", "rho1", "-", "104", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [11, 12]}}
{"token": ["The", "C0178664#ent", "<e1>", "GSI", ")", "was", "higher", "in", "the", "C1823902#ent", "<e2>", "group", "than", "in", "the", "control", "group"], "h": {"id": "C0178664", "name": "C0178664#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823902", "name": "C1823902#ent", "pos": [9, 10]}}
{"token": ["C0299505#ent", "<e1>", "also", "ubiquitylates", "the", "large", "subunit", "of", "RNA", "polymerase", "II", "C1333229#ent", "<e2>", ",", "phosphorylated", "on", "serine", "5", "Ser5", ")", "within", "the", "C-terminal", "domain", "CTD", ")", "."], "h": {"id": "C0299505", "name": "C0299505#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333229", "name": "C1333229#ent", "pos": [11, 12]}}
{"token": ["A", "70-year-old", "woman", ",", "with", "a", "history", "of", "C0011849#ent", "<e1>", "and", "persistent", "corneal", "ulceration", "developed", "a", "severe", "C0022568#ent", "<e2>", "caused", "by", "Candida", "albicans"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022568", "name": "C0022568#ent", "pos": [17, 18]}}
{"token": ["Binding", "of", "subfragment", "1", "C2350558#ent", "<e1>", "Affi-Gel", "Blue", "does", "not", "involve", "the", "C1705556#ent", "<e2>", "binding", "site", "myosin", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [12, 13]}}
{"token": ["The", "C2350558#ent", "<e1>", "ATPase/synthase", "was", "used", "for", "generation", "of", "C1705556#ent", "<e2>", "from", "ADP", "and", "P(i", ")", "at", "the", "expense", "of", "electrochemical", "potential", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [9, 10]}}
{"token": ["Forty-seven", "percent", "of", "these", "C1420459#ent", "<e1>", "clones", "had", "significant", "homology", "to", "functional", "proteins", "as", "protein", "kinases", "C0207564#ent", "<e2>", "nucleic", "acid", "binding", "protein", "chloride", "channel", "protein"], "h": {"id": "C1420459", "name": "C1420459#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0207564", "name": "C0207564#ent", "pos": [16, 17]}}
{"token": ["The", "effects", "of", "C0121300#ent", "<e1>", "cobalt", "protoporphyrin", "the", "activity", "of", "C0053602#ent", "<e2>", "been", "examined", "."], "h": {"id": "C0121300", "name": "C0121300#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0053602", "name": "C0053602#ent", "pos": [10, 11]}}
{"token": ["More", "specifically", ",", "a", "C1705831#ent", "<e1>", "knock-out", "cell", "line", "expressing", "NS5A", "and", "other", "nonstructural", "proteins", "prevented", "the", "NF-kappaB", "activation", "indicating", "the", "involvement", "of", "C1705831#ent", "<e1>", "as", "a", "probable", "C1421249#ent", "<e1>", "the", "activation", "process"], "h": {"id": "C1705831", "name": "C1705831#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [28, 29]}}
{"token": ["STAM", "is", "associated", "with", "Jak3", "and", "C1527617#ent", "<e1>", "its", "ITAM", "region", "phosphorylated", "by", "Jak3", "and", "C1334291#ent", "<e2>", "upon", "stimulation", "with", "IL-2", "and", "GM-CSF", ",", "respectively", "."], "h": {"id": "C1527617", "name": "C1527617#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334291", "name": "C1334291#ent", "pos": [15, 16]}}
{"token": ["The", "constitutive", "activation", "of", "C1527617#ent", "<e1>", "does", "not", "result", "from", "chromosomal", "aberrations", "the", "C1334291#ent", "<e2>", "but", "most", "probably", "from", "abnormally", "activated", "transduction", "systems", "operative", "in", "glioblastoma", "cells"], "h": {"id": "C1527617", "name": "C1527617#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334291", "name": "C1334291#ent", "pos": [13, 14]}}
{"token": ["These", "are", ",", "azathioprine", ",", "estrogens", ",", "furosemide", ",", "C0025741#ent", "<e1>", ",", "pentamidine", ",", "procainamide", ",", "C3539179#ent", "<e2>", ",", "and", "thiazide", "diuretics"], "h": {"id": "C0025741", "name": "C0025741#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539179", "name": "C3539179#ent", "pos": [16, 17]}}
{"token": ["A", "key", "step", "in", "this", "process", "is", "catalyzed", "by", "a", "C1307637#ent", "<e1>", "as", "the", "anaphase-promoting", "complex", "C0033036#ent", "<e2>", ")", ",", "the", "regulation", "of", "which", "is", "poorly", "understood", "."], "h": {"id": "C1307637", "name": "C1307637#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [16, 17]}}
{"token": ["This", "role", "may", "be", "taken", "up", "by", "certain", "antineoplastic", "drugs", "such", "as", "alkylphosphocholine-1", "(", "C0068006#ent", "<e1>", ")", ",", "that", "also", "have", "C0003416#ent", "<e2>"], "h": {"id": "C0068006", "name": "C0068006#ent", "pos": [14, 15]}, "relation": "has_therapeutic_class", "t": {"id": "C0003416", "name": "C0003416#ent", "pos": [21, 22]}}
{"token": ["The", "natriuretic", "effects", "furosemide", "and", "the", "long-acting", "loop", "diuretic", "C0076840#ent", "<e1>", "have", "been", "compared", "in", "patients", "with", "C0022661#ent", "<e2>", "and", "without", "nephrotic", "syndrome"], "h": {"id": "C0076840", "name": "C0076840#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [17, 18]}}
{"token": ["A", "primary", "bovine", "herpesvirus-1", "BHV-1", ")", "C0035243#ent", "<e1>", "by", "a", "secondary", "challenge", "Mannheimia", "haemolytica", "results", "in", "fatal", "C1449809#ent", "<e2>", "BRD", ")", "and", "host", "responses", "these", "two", "pathogens", "have", "been", "studied", "extensively", "."], "h": {"id": "C0035243", "name": "C0035243#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1449809", "name": "C1449809#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", "the", "role", "of", "C1424792#ent", "<e1>", "the", "antimutagenic", "actions", "riboflavin", "and", "reduced", "glutathione", "against", "mutagenic", "potentials", "4-nitroquinoline", "1-oxide", "C0026254#ent", "<e2>", "been", "investigated", "."], "h": {"id": "C1424792", "name": "C1424792#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [20, 21]}}
{"token": ["Although", "primary", "angle-closure", "glaucoma", "treated", "with", "miotics", "and", "peripheral", "iridectomy", "such", "therapy", "may", "worsen", "the", "C0017601#ent", "<e1>", "in", "eyes", "with", "C0017605#ent", "<e2>", "to", "a", "ciliochoridal", "detachment", "."], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [20, 21]}}
{"token": ["Multiple", "biomarker", "patterns", "clearly", "distinguished", "healthy", "controls", "C0010068#ent", "<e1>", "patients", ",", "and", "we", "extracted", "15", "C0030956#ent", "<e2>", "that", "define", "a", "characteristic", "C0010068#ent", "<e1>", "signature", "panel", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [7, 8]}}
{"token": ["Charged", "derivatives", "of", "C0030956#ent", "<e1>", "are", "useful", "in", "obtaining", "simpler", "collision-activated", "dissociation", "(", "C0010068#ent", "<e2>", ")", "mass", "spectra"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [13, 14]}}
{"token": ["C0002260#ent", "<e1>", "is", "a", "specific", "inhibitor", "of", "C1417932#ent", "<e2>", "the", "rate-limiting", "enzyme", "of", "polyamine", "biosynthesis"], "h": {"id": "C0002260", "name": "C0002260#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417932", "name": "C1417932#ent", "pos": [7, 8]}}
{"token": ["Systemic", "signs", "a", "severe", "hepatopathy", ",", "C0013404#ent", "<e1>", ",", "pyrexia", "and", "C1516009#ent", "<e2>", "."], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516009", "name": "C1516009#ent", "pos": [11, 12]}}
{"token": ["Obesity", "resides", "upstream", "of", "the", "constituents", "of", "C0006112#ent", "<e1>", "as", "diabetes", ",", "hypertension", ",", "hyperlipidemia", ",", "and", "C0003850#ent", "<e2>", "."], "h": {"id": "C0006112", "name": "C0006112#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [17, 18]}}
{"token": ["Tyrosine-phosphorylated", "Erk-2", ",", "a", "C0170168#ent", "<e1>", "identified", "as", "one", "of", "the", "proteins", "in", "C1705010#ent", "<e2>", "was", "significantly", "decreased", "in", "hyperapoB", "cells", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705010", "name": "C1705010#ent", "pos": [13, 14]}}
{"token": ["To", "investigate", "the", "effect", "of", "tanshinone", "IIA", "HL-60", "and", "K562", "cells", "apoptosis", ",", "and", "to", "assay", "the", "inhibition", "of", "the", "C0087071#ent", "<e1>", "the", "leukemia", "cell", "apoptosis", "induced", "by", "C0075810#ent", "<e2>", "."], "h": {"id": "C0087071", "name": "C0087071#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0075810", "name": "C0075810#ent", "pos": [28, 29]}}
{"token": ["After", "the", "onset", "of", "parasite", "egg", "deposition", "mice", "infected", "with", "the", "C0162667#ent", "<e1>", "Schistosoma", "mansoni", "mount", "strong", "Th2", "cytokine", "responses", "the", "absence", "of", "significant", "C3540579#ent", "<e2>", "cytokine", "synthesis"], "h": {"id": "C0162667", "name": "C0162667#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [24, 25]}}
{"token": ["However", ",", "this", "C0285558#ent", "<e1>", "mutant", "did", "partially", "block", "C1335645#ent", "<e2>", "activation", "by", "insulin", ",", "indicating", "C0285558#ent", "<e1>", "is", "required", "here", "."], "h": {"id": "C0285558", "name": "C0285558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335645", "name": "C1335645#ent", "pos": [9, 10]}}
{"token": ["The", "specific", "C0007407#ent", "<e1>", "inhibitors", ",", "nitecapone", "and", "C0134032#ent", "<e2>", ",", "effectively", "inhibited", "in", "vitro", "human", "intestinal", "C0007407#ent", "<e1>", "activity", "."], "h": {"id": "C0007407", "name": "C0007407#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0134032", "name": "C0134032#ent", "pos": [8, 9]}}
{"token": ["We", "report", "on", "a", "19-year-old", "woman", "with", "C0000889#ent", "<e1>", "the", "inherited", "type", "and", "concomitant", "C0042900#ent", "<e2>", "."], "h": {"id": "C0000889", "name": "C0000889#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [14, 15]}}
{"token": ["Zafirlukast", "is", "a", "C0595726#ent", "<e1>", "to", "treat", "allergic", "and", "C0004099#ent", "<e2>"], "h": {"id": "C0595726", "name": "C0595726#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [9, 10]}}
{"token": ["Previously", ",", "we", "demonstrated", "that", "bradykinin", "excited", "sensory", "neurons", "by", "activating", "C1421467#ent", "<e1>", "via", "the", "C1744607#ent", "<e2>", "PLA(2", ")", ")", "and", "lipoxygenase", "(", "LO", ")", "pathway", "."], "h": {"id": "C1421467", "name": "C1421467#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1744607", "name": "C1744607#ent", "pos": [15, 16]}}
{"token": ["In", "3", "regressor", "dogs", "that", "received", "a", "second", "transplant", "of", "C3538751#ent", "<e1>", ",", "the", "mean", "concentration", "of", "circulating", "C0020951#ent", "<e2>", "significantly", "greater", "than", "the", "mean", "for", "progressor", "dogs", "."], "h": {"id": "C3538751", "name": "C3538751#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [18, 19]}}
{"token": ["C1415001#ent", "<e1>", "GSD-IV", ")", "is", "a", "rare", "C3899988#ent", "<e2>", "to", "mutations", "in", "the", "GBE1", "gene", "deficiency", "of", "the", "glycogen", "branching", "enzyme", "GBE", ")", "."], "h": {"id": "C1415001", "name": "C1415001#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [7, 8]}}
{"token": ["The", "Caenorhabditis", "elegans", "genome", "encodes", "two", "Ptc", "C4277608#ent", "<e1>", "and", "one", "related", "pseudogene", "but", "does", "not", "encode", "obvious", "C0062941#ent", "<e2>", "or", "Smo", "C4277608#ent", "<e1>", "."], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [7, 8]}}
{"token": ["In", "these", "G1-arrested", "cells", "C0079933#ent", "<e1>", "does", "not", "interfere", "with", "the", "activation", "of", "cyclin", "D1", "C0080054#ent", "<e2>"], "h": {"id": "C0079933", "name": "C0079933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [15, 16]}}
{"token": ["In", "humans", "there", "is", "increased", "lipid", "peroxidation", "C1420193#ent", "<e1>", "reduction", "in", "some", "C0003402#ent", "<e2>", "and", "increased", "urinary", "excretion", "8-iso-prostaglandin", "F(2alpha", "and", "8-oxo-7,8", "dihydro-2", "deoxyguanosine"], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003402", "name": "C0003402#ent", "pos": [12, 13]}}
{"token": ["Inhibition", "of", "thyroid", "hormone", "effect", "in", "the", "heart", "may", "contribute", "to", "the", "C0003195#ent", "<e1>", "properties", "of", "C0002598#ent", "<e2>", ";", "however", ",", "it", "can", "not", "be", "concluded", "that", "C0002598#ent", "<e2>", "is", "responsible", "for", "the", "tardive", "drug", "effect"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [12, 13]}, "relation": "therapeutic_class_of", "t": {"id": "C0002598", "name": "C0002598#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "compare", "the", "concentrations", "of", "TGF-beta1", "and", "TGF-beta2", "in", "the", "C1704942#ent", "<e1>", "of", "patients", "with", "C1535939#ent", "<e2>", "and", "other", "lung", "diseases"], "h": {"id": "C1704942", "name": "C1704942#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [21, 22]}}
{"token": ["Nevertheless", ",", "we", "found", "neither", "C0001942#ent", "<e1>", "activity", "in", "LuHNL", "nor", "C2346625#ent", "<e2>", "activity", "in", "ADH", "."], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2346625", "name": "C2346625#ent", "pos": [11, 12]}}
{"token": ["An", "extract", "of", "the", "C0771711#ent", "<e1>", "of", "one", "such", "fish", ",", "the", "Pacific", "ratfish", "Hydrolagus", "colliei", "contained", "C0143060#ent", "<e2>", "141", "pmol/g", "wet", "wt", ")", ",", "measured", "with", "an", "antiserum", "raised", "against", "mammalian", "somatostatin-14", "."], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0143060", "name": "C0143060#ent", "pos": [17, 18]}}
{"token": ["The", "feedforward", "intentional", "theory", "C0234507#ent", "<e1>", "suggests", "that", "the", "discovery", "of", "C0427055#ent", "<e2>", "is", "dependent", "on", "attempted", "action", "and", "some", "patients", "might", "have", "C0234507#ent", "<e1>", "because", "they", "do", "not", "attempt", "to", "move", "."], "h": {"id": "C0234507", "name": "C0234507#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [11, 12]}}
{"token": ["Bik", "and", "C1332397#ent", "<e1>", "were", "expressed", "in", "other", "endocrine", "islet", "cells", "well", "as", "in", "the", "C0700138#ent", "<e2>"], "h": {"id": "C1332397", "name": "C1332397#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700138", "name": "C0700138#ent", "pos": [15, 16]}}
{"token": ["Whereas", "C0937932#ent", "<e1>", "homogeneously", "distributed", "through", "the", "acinus", ",", "the", "activities", "of", "C1450094#ent", "<e2>", "alpha-hydroxyacid", "oxidase", "respectively", "1.80-", "and", "2.71-fold", "higher", "in", "the", "periportal", "hepatocytes", "than", "in", "the", "perivenous", "hepatocytes", "."], "h": {"id": "C0937932", "name": "C0937932#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1450094", "name": "C1450094#ent", "pos": [12, 13]}}
{"token": ["The", "difference", "in", "the", "excitation", "maxima", "for", "the", "two", "complexes", "has", "been", "used", "to", "advantage", "for", "the", "estimation", "of", "C1704663#ent", "<e1>", "in", "the", "presence", "of", "C1705304#ent", "<e2>", "."], "h": {"id": "C1704663", "name": "C1704663#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [25, 26]}}
{"token": ["C1416800#ent", "<e1>", "and", "SP-2", "each", "consist", "of", "six", "C0599220#ent", "<e2>", "and", "have", "the", "molecular", "mass", "79", "KDa", "and", "82.5", "KDa", ",", "respectively", "."], "h": {"id": "C1416800", "name": "C1416800#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "show", "that", "ablation", "of", "proteins", "required", "for", "MT-kinetochore", "attachment", "(", "Hec1/Ndc80", ",", "C1826495#ent", "<e1>", ")", "disrupts", "RanGAP1", "and", "C1419259#ent", "<e2>", "targeting", "to", "kinetochores", "."], "h": {"id": "C1826495", "name": "C1826495#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419259", "name": "C1419259#ent", "pos": [20, 21]}}
{"token": ["Heritable", "disorders", "C0009325#ent", "<e1>", "include", "Ehler-Danlos", "syndromes", "11", "types", "are", "actually", "known", ")", ",", "C1867020#ent", "<e2>", "osteogenesis", "imperfecta"], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1867020", "name": "C1867020#ent", "pos": [14, 15]}}
{"token": ["Forskolin", "and", "C0000096#ent", "<e1>", "did", "not", "change", "the", "levels", "of", "the", "general", "neuronal", "markers", "C1414404#ent", "<e2>", "synaptophysin", ",", "suggesting", "that", "the", "effect", "of", "these", "drugs", "was", "specific", "for", "vasopressin-expressing", "cells"], "h": {"id": "C0000096", "name": "C0000096#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414404", "name": "C1414404#ent", "pos": [14, 15]}}
{"token": ["Surprisingly", ",", "this", "compound", "acts", "in", "a", "gene-selective", "manner", "in", "vivo", "it", "is", "an", "C2987634#ent", "<e1>", "on", "CYP7A1", ",", "an", "antagonist", "on", "C3890553#ent", "<e2>", ",", "and", "is", "neutral", "on", "SHP", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3890553", "name": "C3890553#ent", "pos": [22, 23]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "assess", "the", "cumulative", "prevalence", "of", "C0001309#ent", "<e1>", "children", "with", "C0035455#ent", "<e2>", ",", "asthma", "and", "eczema", "in", "a", "secondary", "pediatric", "outpatient", "clinic", "."], "h": {"id": "C0001309", "name": "C0001309#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [16, 17]}}
{"token": ["C0001309#ent", "<e1>", "often", "occurs", "simultaneously", "with", "C0035455#ent", "<e2>", "in", "seasonal", "allergy", "sufferers", "."], "h": {"id": "C0001309", "name": "C0001309#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [6, 7]}}
{"token": ["The", "effect", "of", "orally", "fed", "C1260024#ent", "<e1>", "examined", "on", "the", "activities", "of", "cholinergic", "C0014442#ent", "<e2>", "in", "the", "guinea", "pig", "brain", "."], "h": {"id": "C1260024", "name": "C1260024#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["The", "obtained", "results", "can", "be", "used", "for", "more", "profound", "understanding", "of", "interdependence", "between", "the", "C0633225#ent", "<e1>", "activity", "and", "lipid", "mechanisms", "cell", "injury", "their", "role", "in", "pathogenesis", "of", "C0027719#ent", "<e2>", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027719", "name": "C0027719#ent", "pos": [27, 28]}}
{"token": ["C0965129#ent", "<e1>", "is", "a", "highly", "potent", "C3536932#ent", "<e2>"], "h": {"id": "C0965129", "name": "C0965129#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536932", "name": "C3536932#ent", "pos": [6, 7]}}
{"token": ["When", "C-terminal-truncated", "Smad1", "and", "C1416963#ent", "<e1>", "were", "transfected", "into", "C0907533#ent", "<e2>", "active", "BMP", "receptor", "type", "IB", "C2C12", "cells", ",", "BMP", "signals", "were", "blocked", ",", "resulting", "in", "an", "increase", "in", "myogenin-CAT", "activity", "."], "h": {"id": "C1416963", "name": "C1416963#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}}
{"token": ["Sixty-six", "adults", "with", "chronic", "autoimmune", "thrombocytopenic", "purpura", "C0398650#ent", "<e1>", "and", "platelet", "count", "50", "x", "10(9)/l", "were", "treated", "with", "C0010980#ent", "<e2>", "(", "75", "-", "100", "mg", "orally", ")", "."], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [18, 19]}}
{"token": ["Nevertheless", ",", "patients", "with", "frequent", "and", "recurring", "C0149931#ent", "<e1>", ",", "who", "suffer", "a", "reduced", "C0518214#ent", "<e2>", ",", "continue", "to", "be", "underrecognized", "and", "undertreated", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0518214", "name": "C0518214#ent", "pos": [14, 15]}}
{"token": ["C0020197#ent", "<e1>", "inhibits", "reversibly", "the", "insulinotropic", "action", "of", "C0724709#ent", "<e2>", "without", "affecting", "that", "of", "glucose", "also", "in", "mouse", "and", "rat", "isolated", "pancreatic", "islets"], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0724709", "name": "C0724709#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "C1710644#ent", "<e1>", "coexpression", "enhances", "C1333891#ent", "<e2>", "and", "HDAC2-mediated", "repression", "in", "transcriptional", "reporter", "assays", "."], "h": {"id": "C1710644", "name": "C1710644#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [6, 7]}}
{"token": ["Mdr2", "protein", "levels", "were", "increased", ",", "whereas", "C4084714#ent", "<e1>", ",", "Ntcp", "and", "C1422214#ent", "<e2>", "were", "drastically", "decreased", "."], "h": {"id": "C4084714", "name": "C4084714#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422214", "name": "C1422214#ent", "pos": [12, 13]}}
{"token": ["The", "Bmax", "and", "C0026691#ent", "<e1>", "for", "both", "C1416886#ent", "<e2>", "and", "D2", "receptors", "not", "changed", "in", "rat", "striatum", "by", "neonatal", "6-OHDA", "treatment", ",", "even", "though", "dopamine", "content", "was", "reduced", "by", "96", "%", "."], "h": {"id": "C0026691", "name": "C0026691#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416886", "name": "C1416886#ent", "pos": [7, 8]}}
{"token": ["Conventional", "and", "conservative", "restorations", "are", "vulnerable", "to", "C0333519#ent", "<e1>", "recurrence", ",", "material", "failure", "and", "C0268487#ent", "<e2>"], "h": {"id": "C0333519", "name": "C0333519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [14, 15]}}
{"token": ["C0085196#ent", "<e1>", "lesions", "of", "the", "C0052080#ent", "<e2>", "in", "the", "prefrontal", "cortex", "the", "anterior", "striatum", "the", "nucleus", "accumbens", "to", "similar", "behavioural", "deficits"], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0052080", "name": "C0052080#ent", "pos": [5, 6]}}
{"token": ["We", "used", "denaturing", "gradient", "gel", "electrophoresis", "DGGE", ")", "to", "screen", "PCR", "amplified", "exons", "of", "C1413586#ent", "<e1>", "for", "point", "mutations", "in", "a", "set", "of", "18", "C1567741#ent", "<e2>", "patients", "previously", "characterized", "by", "Southern", "blotting"], "h": {"id": "C1413586", "name": "C1413586#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C1567741", "name": "C1567741#ent", "pos": [24, 25]}}
{"token": ["Mutations", "in", "the", "COL4A5", "gene", "the", "C1413586#ent", "<e1>", "been", "found", "in", "linkage", "with", "C1567741#ent", "<e2>", "AS", ")", "."], "h": {"id": "C1413586", "name": "C1413586#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C1567741", "name": "C1567741#ent", "pos": [13, 14]}}
{"token": ["Thus", "ATR", "is", "a", "new", "member", "of", "a", "sub-family", "of", "PIK", "related", "C0031727#ent", "<e1>", ",", "founded", "by", "the", "C1528018#ent", "<e2>", ",", "which", "are", "activated", "in", "the", "presence", "of", "DNA", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528018", "name": "C1528018#ent", "pos": [18, 19]}}
{"token": ["To", "identify", "substrates", "for", "ATM", "and", "the", "related", "C0031727#ent", "<e1>", "ATR", "and", "C1528018#ent", "<e2>", ",", "we", "optimized", "in", "vitro", "assays", "and", "developed", "a", "rapid", "peptide", "screening", "method", "determine", "general", "phosphorylation", "consensus", "sequences", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1528018", "name": "C1528018#ent", "pos": [12, 13]}}
{"token": ["Among", "the", "genes", "deregulated", "by", "C1706265#ent", "<e1>", ",", "the", "expression", "of", "C0387583#ent", "<e2>", "(", "COX-2", ")", "mRNA", "was", "significantly", "suppressed", "by", "C1706265#ent", "<e1>", "(", "2.4-fold", ")", "."], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1706265", "name": "C1706265#ent", "pos": [5, 6]}}
{"token": ["Interestingly", ",", "treatment", "with", "either", "C0663262#ent", "<e1>", "or", "A192621", "significantly", "decreased", "cardiac", "hypertrophy", "rats", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0663262", "name": "C0663262#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [15, 16]}}
{"token": ["In", "postmenopausal", "women", ",", "C0076836#ent", "<e1>", "had", "little", "or", "no", "effect", "C1414083#ent", "<e2>", "trends", "."], "h": {"id": "C0076836", "name": "C0076836#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [11, 12]}}
{"token": ["Although", "mineralocorticoid", "receptor", "antagonism", "reduces", "mortality", "in", "patients", "with", "C0018802#ent", "<e1>", "the", "progestational", "and", "C0002842#ent", "<e2>", "side", "effects", "of", "the", "nonspecific", "mineralocorticoid", "receptor", "antagonist", "spironolactone", ",", "have", "limited", "its", "usefulness", "in", "the", "treatment", "of", "cardiovascular", "diseases"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [14, 15]}}
{"token": ["C0042769#ent", "<e1>", "induced", "microglial", "and", "macrophage", "expression", "of", "two", "disintegrins", "and", "C1334706#ent", "<e2>", "with", "thrombospondin", "motifs", "ADAMTS-1", "and", "ADAMTS-4", ")", ",", "with", "high", "substrate", "specificity", "for", "matrix", "proteoglycans"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [11, 12]}}
{"token": ["Regulation", "of", "expression", "of", "C0041487#ent", "<e1>", "TAT", ")", "is", "examined", "in", "two", "cell", "lines", "C0064906#ent", "<e2>", ")", "obtained", "by", "chemical", "transformation", "cultured", "fetal", "hepatocytes", "derived", "from", "19-day", "rat", "fetuses", "(", "FL19", ")", "."], "h": {"id": "C0041487", "name": "C0041487#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0064906", "name": "C0064906#ent", "pos": [14, 15]}}
{"token": ["Activation", "of", "C0027103#ent", "<e1>", "phosphorylation", "of", "the", "20", "kDa", "regulatory", "light", "chains", "C1423704#ent", "<e2>", ")", "has", "been", "implicated", "in", "numerous", "contractile", "and", "motile", "events", "e.g.", ",", "smooth", "muscle", "contraction", "cytokinesis", ",", "and", "cell", "migration"], "h": {"id": "C0027103", "name": "C0027103#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423704", "name": "C1423704#ent", "pos": [12, 13]}}
{"token": ["With", "increasing", "extent", "of", "blood", "loss", "there", "were", "increases", "in", "serum", "TNF-alpha", "levels", ",", "phosphorylation", "of", "C1334140#ent", "<e1>", "serine", "307", ",", "and", "C0380051#ent", "<e2>"], "h": {"id": "C1334140", "name": "C1334140#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [22, 23]}}
{"token": ["Contrary", "to", "expectation", ",", "leucocyte", "movement", "over", "surfaces", "and", "through", "both", "rigid", "and", "deformable", "three-dimensional", "matrices", "(", "micropore", "filters", "C0009325#ent", "<e1>", "is", "unaffected", "by", "C0033607#ent", "<e2>", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [24, 25]}}
{"token": ["C2828027#ent", "<e1>", "classification", "was", "not", "predictive", "of", "C3887634#ent", "<e2>", "expression", ",", "and", "there", "was", "no", "difference", "in", "the", "distribution", "of", "C2828027#ent", "<e1>", "subtypes", "between", "the", "groups", "."], "h": {"id": "C2828027", "name": "C2828027#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887634", "name": "C3887634#ent", "pos": [7, 8]}}
{"token": ["Tumor", "necrosis", "factor", "alpha", "TNFalpha", ")", "blockade", "has", "recently", "been", "found", "to", "be", "ineffective", "in", "treating", "glandular", "and", "extraglandular", "manifestations", "of", "adult", "C1527336#ent", "<e1>", "SS", ")", ",", "including", "arthralgia", "and", "C0003864#ent", "<e2>", "."], "h": {"id": "C1527336", "name": "C1527336#ent", "pos": [22, 23]}, "relation": "related_to", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [30, 31]}}
{"token": ["This", "review", "describes", "new", "drugs", "targeting", "BCR-Abl", ",", "C1704888#ent", "<e1>", ",", "EGFR", "(", "epidermal", "growth", "factor", "receptor", ",", "tumor", "angiogenesis", "VEGF", "(", "C1522575#ent", "<e2>", ",", "HER2/neu", "and", "\"", "multitarget", "\"", "tyrosine", "kinase", "inhibitors"], "h": {"id": "C1704888", "name": "C1704888#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "report", "an", "interaction", "uncovered", "in", "this", "screening", "with", "C1419922#ent", "<e1>", ",", "a", "mammalian", "C3815886#ent", "<e2>", "may", "function", "as", "a", "phospholipid", "transfer", "protein"], "h": {"id": "C1419922", "name": "C1419922#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3815886", "name": "C3815886#ent", "pos": [15, 16]}}
{"token": ["Transfections", "into", "the", "cultured", "GnRH-secreting", "hypothalamic", "neuronal", "cell", "line", "C1417549#ent", "<e1>", "have", "identified", "a", "C1880904#ent", "<e2>", "1.5", "kb", "upstream", "of", "the", "GnRH", "gene", "which", "binds", "multiple", "GT1", "nuclear", "proteins"], "h": {"id": "C1417549", "name": "C1417549#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [14, 15]}}
{"token": ["It", "is", "likely", "that", "C0534137#ent", "<e1>", "functions", "as", "a", "substrate", "transporter", "some", "isoforms", "of", "C4284131#ent", "<e2>", "via", "possible", "interactions", "between", "C4284131#ent", "<e2>", "and", "C0534137#ent", "<e1>", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4284131", "name": "C4284131#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "lower", "frequencies", "of", "C0012634#ent", "<e1>", "been", "seen", "in", "those", "on", "HIV", "therapy", "except", "that", "C1705714#ent", "<e2>", "become", "more", "common", "as", "the", "viral", "load", "falls", "CD4", "count", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705714", "name": "C1705714#ent", "pos": [16, 17]}}
{"token": ["The", "former", "two", "C0026249#ent", "<e1>", "phosphorylated", "ERK1/2", ",", "its", "substrate", "p90rsk", ",", "and", "C1413702#ent", "<e2>", "."], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413702", "name": "C1413702#ent", "pos": [13, 14]}}
{"token": ["We", "determined", "whether", "C0342257#ent", "<e1>", "complications", "or", "treatments", "are", "associated", "with", "risk", "of", "falls", "in", "C0362046#ent", "<e2>", "adults", "."], "h": {"id": "C0342257", "name": "C0342257#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [15, 16]}}
{"token": ["delta", "C0271829#ent", "<e1>", "evoked", "by", "C0065600#ent", "<e2>", "or", "palatinose", "were", "low", ",", "and", "delta", "C0271829#ent", "<e1>", "evoked", "by", "fructo-oligosaccharides", "were", "negligible", "."], "h": {"id": "C0271829", "name": "C0271829#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0065600", "name": "C0065600#ent", "pos": [5, 6]}}
{"token": ["The", "results", "indicate", "that", "C1420621#ent", "<e1>", "may", "play", "a", "C0242912#ent", "<e2>", "periods", "of", "pH", "stress", "upregulating", "oxygen", "radical", "scavenging", "systems", "."], "h": {"id": "C1420621", "name": "C1420621#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [9, 10]}}
{"token": ["Peptides", "corresponding", "to", "epitopes", "SLP-76", "C3813239#ent", "<e1>", ",", "SoS", "and", "other", "C0086376#ent", "<e2>", "with", "related", "sequences", ",", "as", "well", "as", "mutant", "peptides", "were", "synthesized", "and", "analysed", "by", "tryptophan-fluorescence", "spectrometry", "by", "in", "vitro", "competition", "experiments", "."], "h": {"id": "C3813239", "name": "C3813239#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Different", "biochemical", "procedures", "us", "to", "identify", "the", "defective", "C0079429#ent", "<e1>", "in", "9", "PCCA", "deficient", "and", "28", "C1418304#ent", "<e2>", "deficient", "patients", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418304", "name": "C1418304#ent", "pos": [16, 17]}}
{"token": ["The", "modulatory", "effect", "heparin", "and", "C0079224#ent", "<e1>", "(", "sulfated", "polysaccharides", "was", "studied", "on", "ATPDase", "and", "C2932861#ent", "<e2>", "activities", "."], "h": {"id": "C0079224", "name": "C0079224#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2932861", "name": "C2932861#ent", "pos": [15, 16]}}
{"token": ["A", "comparison", "of", "promoter", "sequences", "that", "sequences", "within", "this", "region", "of", "the", "C0017337#ent", "<e1>", "highly", "homologous", "to", "C1418457#ent", "<e2>", "between", "-110", "and", "-80", ")", "designated", "ENKCRE-1", "and", "ENKCRE-2", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418457", "name": "C1418457#ent", "pos": [17, 18]}}
{"token": ["Naive", "rats", "receiving", "a", "stress", "stimulus", "a", "significant", "decrease", "of", "C1418457#ent", "<e1>", "derived", "peptides", "in", "BMMC", ",", "C1823138#ent", "<e2>", "and", "SMC", "."], "h": {"id": "C1418457", "name": "C1418457#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1823138", "name": "C1823138#ent", "pos": [17, 18]}}
{"token": ["We", "present", "a", "case", "of", "C0494475#ent", "<e1>", "on", "day", "four", "post", "partum", "associated", "with", "severe", "C0270697#ent", "<e2>"], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [15, 16]}}
{"token": ["Two", "of", "the", "patients", "presented", "with", "C0494475#ent", "<e1>", "one", "presented", "with", "a", "C0270697#ent", "<e2>", "."], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0270697", "name": "C0270697#ent", "pos": [12, 13]}}
{"token": ["It", "is", "suggested", "that", "long-term", "use", "of", "C0086073#ent", "<e1>", "bronchial", "hyperresponsiveness", "concomitant", "with", "improved", "symptomatology", "in", "C0004096#ent", "<e2>", "children", "."], "h": {"id": "C0086073", "name": "C0086073#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["It", "follows", "that", "quinolinic", "acid", "C3536880#ent", "<e1>", "directly", "converted", "to", "nicotinic", "acid", "mononucleotide", "the", "respective", "C0729570#ent", "<e2>", ",", "but", "nicotinamide", "appeared", "to", "be", "converted", "to", "nicotinic", "acid", "mononucleotide", "conversion", "to", "C3536880#ent", "<e1>"], "h": {"id": "C3536880", "name": "C3536880#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0729570", "name": "C0729570#ent", "pos": [15, 16]}}
{"token": ["Normal", "brain", "no", "staining", "C1420084#ent", "<e1>", ",", "and", "in", "C0038522#ent", "<e2>", "brain", "only", "subsets", "of", "leukocytes", "in", "inflammatory", "infiltrates", "positive", "."], "h": {"id": "C1420084", "name": "C1420084#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038522", "name": "C0038522#ent", "pos": [9, 10]}}
{"token": ["These", "results", "indicate", "that", "inositol-1,4,5-triphosphate", "formation", "and", "arachidonate", "release", "and", "C0040060#ent", "<e1>", "controlled", "separately", "and", "are", "mediated", "by", "different", "C0086376#ent", "<e2>", "which", "are", "coupled", "to", "phospholipase", "C", "phospholipase", "A2", "in", "platelets", "."], "h": {"id": "C0040060", "name": "C0040060#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}}
{"token": ["There", "is", "debate", "concerning", "the", "involvement", "of", "C1456378#ent", "<e1>", "MAPK", ")", "in", "ischemic", "preconditioning", "C1418943#ent", "<e2>", ")", "."], "h": {"id": "C1456378", "name": "C1456378#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418943", "name": "C1418943#ent", "pos": [14, 15]}}
{"token": ["In", "otitis", "media", "19", "and", "3", "predominated", ",", "in", "C0009774#ent", "<e1>", "types", "19", "and", "6", ",", "and", "in", "C0149512#ent", "<e2>", "types", "6", "and", "19", "."], "h": {"id": "C0009774", "name": "C0009774#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [18, 19]}}
{"token": ["Thirteen", "subjects", "with", "seasonal", "allergic", "rhinitis", "nasal", "challenge", "C3537324#ent", "<e1>", "after", "a", "single", "oral", "2", "mg", "dose", "of", "C0052762#ent", "<e2>", "."], "h": {"id": "C3537324", "name": "C3537324#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0052762", "name": "C0052762#ent", "pos": [18, 19]}}
{"token": ["As", "a", "result", ",", "pancreatic", "acinar", "AR42J", "cells", "C0669365#ent", "<e1>", "express", "NADPH", "oxidase", "subunits", "p67phox", "and", "p47phox", "in", "the", "cytosol", "and", "C1456389#ent", "<e2>", "and", "p22phox", "in", "the", "membrane", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1456389", "name": "C1456389#ent", "pos": [21, 22]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "skeletal", "muscle", "cells", "C0669365#ent", "<e1>", "express", "the", "C2830173#ent", "<e2>", "iPLA2", ")", "isoform", "and", "that", "iPLA2", "modulates", "both", "cytosolic", "oxidant", "activity", "and", "contractile", "function"], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2830173", "name": "C2830173#ent", "pos": [12, 13]}}
{"token": ["C3274681#ent", "<e1>", "is", "the", "most", "frequent", "C0919528#ent", "<e2>", "rearrangement", "in", "childhood", "acute", "myeloid", "leukemia", "AML", ")", "and", "it", "may", "be", "also", "found", "in", "acute", "lymphoblastic", "leukemia", "ALL", ")", "of", "patients", "younger", "than", "1-year-old", "(", "infants", ")", "."], "h": {"id": "C3274681", "name": "C3274681#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0919528", "name": "C0919528#ent", "pos": [6, 7]}}
{"token": ["In", "addition", ",", "Southern", "blot", "analysis", "DNA", "from", "interspecific", "backcross", "mice", "indicated", "that", "the", "mouse", "homologues", "C3810538#ent", "<e1>", ",", "Epl3", ",", "and", "Epl4", "map", "to", "a", "C1334043#ent", "<e2>", "mouse", "chromosome", "3"], "h": {"id": "C3810538", "name": "C3810538#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [26, 27]}}
{"token": ["A", "19-year-old", "man", "born", "with", "thyroprivic", "hypothyroidism", "due", "to", "congenital", "development", "defect", "manifested", "hypogonadism", ",", "stunted", "growth", "C0162674#ent", "<e1>", "CPEO", ")", ",", "diffuse", "muscle", "weakness", "wasting", ",", "right", "bundle", "branch", "block", "C0236642#ent", "<e2>"], "h": {"id": "C0162674", "name": "C0162674#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0236642", "name": "C0236642#ent", "pos": [31, 32]}}
{"token": ["The", "formation", "of", "the", "exoenzymes", ",", "neutral", "and", "C1563389#ent", "<e1>", "well", "as", "C0002245#ent", "<e2>", "of", "Bacillus", "subtilis", "is", "characterized", "by", "the", "same", "time", "course"], "h": {"id": "C1563389", "name": "C1563389#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [12, 13]}}
{"token": ["Cathepsin", "L", "avian", "osteoclasts", "was", "also", "25-fold", "higher", "than", "C0007428#ent", "<e1>", "Chicken", "osteoclasts", "treated", "with", "C0053318#ent", "<e2>", ",", "a", "generalized", "cysteine", "proteinase", "inhibitor", "had", "both", "cathepsins", "inhibited", "to", "the", "same", "extent", "."], "h": {"id": "C0007428", "name": "C0007428#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0053318", "name": "C0053318#ent", "pos": [15, 16]}}
{"token": ["A", "64-year-old", "woman", "suffered", "from", "C0024894#ent", "<e1>", "while", "being", "treated", "by", "corticosteroid", "therapy", "C0030805#ent", "<e2>", "."], "h": {"id": "C0024894", "name": "C0024894#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030805", "name": "C0030805#ent", "pos": [13, 14]}}
{"token": ["Infusion", "of", "a", "C2347168#ent", "<e1>", "estradiol-primed", "rats", "blocks", "C3536710#ent", "<e2>", "facilitation", "and", "sequential", "inhibition", "of", "lordosis", "and", "proceptive", "behaviors"], "h": {"id": "C2347168", "name": "C2347168#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3536710", "name": "C3536710#ent", "pos": [8, 9]}}
{"token": ["In", "Experiment", "1", "the", "C2347168#ent", "<e1>", "PD98059", "was", "infused", "intracerebroventricularly", "before", "C3536710#ent", "<e2>", "administration", "."], "h": {"id": "C2347168", "name": "C2347168#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536710", "name": "C3536710#ent", "pos": [11, 12]}}
{"token": ["For", "etoposide", "(", "VP-16", ")", ",", "increased", "expression", "of", "MDR-1", "or", "C1825410#ent", "<e1>", "and", "alterations", "in", "C1172436#ent", "<e2>", "been", "shown", "to", "confer", "tolerance", "."], "h": {"id": "C1825410", "name": "C1825410#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1172436", "name": "C1172436#ent", "pos": [16, 17]}}
{"token": ["The", "LIFE", "study", "\"", "Losartan", "Intervention", "For", "Endpoint", "reduction", "in", "C0020538#ent", "<e1>", ")", "demonstrated", "a", "significant", "cardiovascular", "protection", "an", "angiotensin", "AT1", "receptor", "antagonist", "C0126174#ent", "<e2>", ",", "in", "hypertensive", "patients", "with", "left", "ventricular", "hypertrophy"], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [23, 24]}}
{"token": ["In", "conclusion", ",", "C0020538#ent", "<e1>", "interferes", "in", "lipid", "metabolism", "reducing", "LPL", "activity", "in", "adipose", "tissue", "while", "C0126174#ent", "<e2>", "administration", "reverses", "this", "effect", "by", "enhancing", "insulin", "release", "and", "reducing", "sympathetic", "nervous", "system", "SNS", ")", "stimulation", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0126174", "name": "C0126174#ent", "pos": [16, 17]}}
{"token": ["Two", "groups", "of", "C0054452#ent", "<e1>", "can", "be", "distinguished", "regarding", "the", "lipoprotein", "lipase", "releasing", "activity", "C1334332#ent", "<e2>", ")", "and", "the", "activated", "partial", "thromboplastin", "time", "APTT", ")", "."], "h": {"id": "C0054452", "name": "C0054452#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334332", "name": "C1334332#ent", "pos": [14, 15]}}
{"token": ["Hyperphagia", "is", "one", "of", "the", "most", "serious", "problems", ",", "which", "is", "organic", "in", "origin", ",", "inducing", "C0028756#ent", "<e1>", "leading", "to", "C0264490#ent", "<e2>"], "h": {"id": "C0028756", "name": "C0028756#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [20, 21]}}
{"token": ["Since", "neuronal", "degeneration", "a", "defining", "feature", "of", "CNS", "C1456654#ent", "<e1>", "TGF-beta", "may", "be", "important", "because", "it", "can", "influence", "C1420257#ent", "<e2>"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420257", "name": "C1420257#ent", "pos": [18, 19]}}
{"token": ["Some", "patients", "with", "nonmalignant", "systemic", "diseases", "like", "collagen", "vascular", "disease", "C0007820#ent", "<e1>", ")", ",", "hypertension", ",", "diabetes", "mellitus", "and", "C0010346#ent", "<e2>", "IBD", ")", ",", "tolerate", "radiation", "therapy", "."], "h": {"id": "C0007820", "name": "C0007820#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [19, 20]}}
{"token": ["These", "include", "human", "C0971087#ent", "<e1>", ",", "a", "bacterial", "C0669516#ent", "<e2>", "SOD", ")", ",", "plant", "cytochrome", "b", "559", "the", "insect", "nuclear", "receptor", "E75", "horse", "heart", "cytochrome", "c", "and", "the", "heme", "domain", "the", "bacterial", "sensor", "protein", "Dos"], "h": {"id": "C0971087", "name": "C0971087#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [8, 9]}}
{"token": ["Transformations", "of", "vindoline", "by", "these", "C0007841#ent", "<e1>", "enhanced", "when", "C0027203#ent", "<e2>", "incubations", "are", "performed", "with", "cofactors", "such", "as", "chlorpromazine", "."], "h": {"id": "C0007841", "name": "C0007841#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["Treatment", "of", "C4284889#ent", "<e1>", "with", "alpha-galactosidase", "gave", "a", "glycolipid", "migrating", "C1417837#ent", "<e2>", "and", "C4284889#ent", "<e1>", ",", "which", "did", "not", "react", "with", "either", "GSL-IB4", "or", "anti-NOR", "antibodies", "did", "react", "with", "GalNAc-specific", "soybean", "agglutinin", "."], "h": {"id": "C4284889", "name": "C4284889#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417837", "name": "C1417837#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", ",", "inhibition", "of", "Src", "or", "C1334706#ent", "<e1>", "caused", "distinct", "effects", "on", "ERK", "activation", "by", "E2", "and", "C0039286#ent", "<e2>", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [18, 19]}}
{"token": ["Moreover", ",", "our", "results", "indicate", "that", "vacuolar", "accumulation", "of", "C0175820#ent", "<e1>", "does", "not", "depend", "solely", "on", "glutathione", "S-transferase", "activity", "C0101555#ent", "<e2>", "transport", "mechanisms", "."], "h": {"id": "C0175820", "name": "C0175820#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [19, 20]}}
{"token": ["Studying", "the", "function/structure", "relationship", "of", "the", "same", "lung", "slices", ",", "we", "evaluated", "C0600370#ent", "<e1>", "airway", "responsiveness", "and", "histology", "of", "C0006267#ent", "<e2>", "and", "respiratory", "bronchioles"], "h": {"id": "C0600370", "name": "C0600370#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [19, 20]}}
{"token": ["Five", "of", "the", "six", "cases", "with", "prior", "clinical", "diagnosis", "C1414137#ent", "<e1>", "were", "found", "to", "have", "C2987364#ent", "<e2>", "JAK2", "."], "h": {"id": "C1414137", "name": "C1414137#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [15, 16]}}
{"token": ["C0244404#ent", "<e1>", "is", "approved", "in", "prevention", "of", "breast", "cancer", "treatment", "of", "C0029458#ent", "<e2>", "but", "its", "use", "can", "increase", "the", "risk", "of", "fatal", "stroke", "."], "h": {"id": "C0244404", "name": "C0244404#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0029458", "name": "C0029458#ent", "pos": [11, 12]}}
{"token": ["C0151747#ent", "<e1>", "plasma", "renin", "activity", "PRA", ")", "elevation", "from", "cyclosporine", "(", "C0520680#ent", "<e2>", ")", "may", "also", "be", "major", "factor", "in", "the", "progress", "of", "hypertension", "."], "h": {"id": "C0151747", "name": "C0151747#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0520680", "name": "C0520680#ent", "pos": [11, 12]}}
{"token": ["A", "total", "of", "89", "adult", "C0020635#ent", "<e1>", "patients", "with", "severe", "GHD", "were", "evaluated", "for", "bone", "mineral", "density", "C0339510#ent", "<e2>", ")", "and", "vertebral", "deformities", "quantitative", "morphometric", "analysis", "."], "h": {"id": "C0020635", "name": "C0020635#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0339510", "name": "C0339510#ent", "pos": [17, 18]}}
{"token": ["Approved", "for", "the", "treatment", "of", "mild", "pneumonia", "this", "C1254351#ent", "<e1>", "was", "investigated", "in", "a", "study", "of", "patients", "hospitalized", "for", "C0694549#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0694549", "name": "C0694549#ent", "pos": [19, 20]}}
{"token": ["The", "immunosuppressive", "effects", "C1412228#ent", "<e1>", "may", "be", "due", "to", "modulation", "of", "cytokine", "production", "and", "C1413243#ent", "<e2>", "expression", "."], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413243", "name": "C1413243#ent", "pos": [14, 15]}}
{"token": ["In", "the", "lower", "pathway", "C1742019#ent", "<e1>", "transformed", "to", "C0054858#ent", "<e2>", ",", "which", "was", "then", "metabolized", "by", "catechol-2,3-dioxygenase", "to", "2-hydroxymuconaldehyde", "acid", "ultimately", "forming", "TCA", "cycle", "intermediates", "."], "h": {"id": "C1742019", "name": "C1742019#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0054858", "name": "C0054858#ent", "pos": [8, 9]}}
{"token": ["To", "identify", "novel", "causes", "of", "C0524851#ent", "<e1>", "we", "extended", "our", "previous", "studies", "of", "TAR", "DNA-binding", "protein", "43", "C1420588#ent", "<e2>", ")", "proteinopathies", "to", "investigate", "C1420588#ent", "<e2>", "as", "a", "candidate", "gene", "in", "familial", "cases", "of", "motor", "neuron", "disease"], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420588", "name": "C1420588#ent", "pos": [17, 18]}}
{"token": ["The", "experiments", "described", "herein", "show", "for", "the", "first", "time", "that", "C0694883#ent", "<e1>", "is", "a", "dynamic", ",", "C1332770#ent", "<e2>", "rapidly", "polarizes", "to", "the", "leading", "edge", "of", "motile", "cancer", "cells"], "h": {"id": "C0694883", "name": "C0694883#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332770", "name": "C1332770#ent", "pos": [16, 17]}}
{"token": ["C0007785#ent", "<e1>", "infarction", ",", "intracerebral", "hemorrhage", "subarachnoid", "hemorrhage", "cerebral", "venous", "thrombosis", "and", "C0042384#ent", "<e2>", "dreaded", "but", "largely", "uncommon", "complications", "of", "most", "rheumatic", "diseases"], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [12, 13]}}
{"token": ["We", "have", "thus", "demonstrated", "that", "the", "activation", "of", "tyrosine", "kinases", "an", "important", "proximate", "step", "in", "PAF-mediated", "signal", "transduction", "B", "cells", "leading", "to", "tyrosine", "phosphorylation", "activation", "of", "C0136864#ent", "<e1>", "Fyn", "and", "Lyn", "kinases", ",", "and", "C2713509#ent", "<e2>"], "h": {"id": "C0136864", "name": "C0136864#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C2713509", "name": "C2713509#ent", "pos": [34, 35]}}
{"token": ["These", "data", "have", "implications", "for", "the", "impact", "of", "C0268576#ent", "<e1>", "on", "obesity-related", "pathophysiological", "conditions", "as", "diabetes", ",", "C0007222#ent", "<e2>", "and", "cancer", "."], "h": {"id": "C0268576", "name": "C0268576#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [17, 18]}}
{"token": ["With", "a", "fluorescent", "conjugate", "the", "heat-stable", "protein", "kinase", "inhibitor", "the", "time-", "and", "dose-dependent", "dissociation", "of", "C0010531#ent", "<e1>", "be", "demonstrated", "following", "C1704793#ent", "<e2>", "stimulation", "of", "Y-1", "adrenal", "tumour", "cells", "and", "the", "kinetics", "of", "its", "free", "catalytic", "subunits", "be", "followed", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [20, 21]}}
{"token": ["Overall", ",", "there", "was", "a", "significant", "relationship", "between", "daily", "stress", "and", "the", "occurrence", "of", "both", "concurrent", "and", "subsequent", "health", "problems", "as", "flu", ",", "C0723402#ent", "<e1>", "headaches", ",", "and", "C0004604#ent", "<e2>", "."], "h": {"id": "C0723402", "name": "C0723402#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0004604", "name": "C0004604#ent", "pos": [28, 29]}}
{"token": ["These", "data", "indicate", "that", "endocytosis", "of", "C1416545#ent", "<e1>", "from", "the", "cell", "surface", "a", "key", "mechanism", "for", "channel", "suppression", "C0033681#ent", "<e2>"], "h": {"id": "C1416545", "name": "C1416545#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [18, 19]}}
{"token": ["Examination", "was", "made", "mainly", "in", "patients", "with", "pulmonary", "and", "extrapulmonary", "tuberculosis", "C0264487#ent", "<e1>", "silicosis", ",", "cancer", ",", "and", "concomitant", "C0029896#ent", "<e2>", "of", "the", "heart", ",", "liver", ",", "kidney", ",", "etc", "."], "h": {"id": "C0264487", "name": "C0264487#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [19, 20]}}
{"token": ["These", "include", "members", "of", "C0162508#ent", "<e1>", "or", "fos", "and", "early", "growth", "response", "C1367595#ent", "<e2>", ")", "gene", "families"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367595", "name": "C1367595#ent", "pos": [12, 13]}}
{"token": ["As", "expected", ",", "caveolin", "and", "GPI-bound", "proteins", "CD55", ",", "C1504686#ent", "<e1>", "and", "GPI-bound", "form", "of", "C1332715#ent", "<e2>", "were", "preferentially", "localized", "in", "detergent-resistant", "membrane", "domains", "(", "DRMs", ")", "."], "h": {"id": "C1504686", "name": "C1504686#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332715", "name": "C1332715#ent", "pos": [15, 16]}}
{"token": ["The", "effects", "of", "increasing", "concentrations", "of", "C0033216#ent", "<e1>", "on", "the", "composition", "of", "the", "C0857393#ent", "<e2>", "gap", "were", "determined", "in", "a", "canine", "model", "of", "atrial", "flutter"], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0857393", "name": "C0857393#ent", "pos": [13, 14]}}
{"token": ["21", "C0017601#ent", "<e1>", "and", "31", "normal", "eyes", "diagnosed", "using", "HRT", "and", "C3538773#ent", "<e2>", "."], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3538773", "name": "C3538773#ent", "pos": [11, 12]}}
{"token": ["Mulberry", "(", "Morus", "indica", "L.", ")", "is", "C0221777#ent", "<e1>", "natural", "therapeutic", "agent", "to", "possess", "hypoglycemic", ",", "hypotensive", ",", "and", "C0596110#ent", "<e2>", "properties", "."], "h": {"id": "C0221777", "name": "C0221777#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [19, 20]}}
{"token": ["Sephadex", "G-50", "column", "chromatography", "the", "C0037500#ent", "<e1>", "extracts", "of", "the", "lysosome-enriched", "fractions", "suggested", "that", "the", "C0079286#ent", "<e2>", "was", "bound", "to", "macromolecules", "intracellularly", "."], "h": {"id": "C0037500", "name": "C0037500#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079286", "name": "C0079286#ent", "pos": [15, 16]}}
{"token": ["In", "the", "present", "study", ",", "different", "antioxidant", "drugs", "(", "C0669516#ent", "<e1>", ",", "allopurinol", "and", "C3273487#ent", "<e2>", "are", "administered", "prior", "to", "liver", "reperfusion", "order", "to", "reduce", "ischemic", "damage"], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273487", "name": "C3273487#ent", "pos": [14, 15]}}
{"token": ["Although", "it", "seems", "to", "cause", "less", "cardiovascular", "effects", "tricyclic", "antidepressants", "the", "C0360108#ent", "<e1>", "mianserin", "also", "has", "been", "reported", "to", "be", "an", "C1516869#ent", "<e2>", "may", ",", "therefore", ",", "also", "interfere", "with", "the", "antihypertensive", "activity", "centrally-acting", "drugs"], "h": {"id": "C0360108", "name": "C0360108#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [21, 22]}}
{"token": ["Three", "families", "of", "C3540790#ent", "<e1>", "can", "perform", "this", "C1416596#ent", "<e2>", "and", "differ", "remarkably", "in", "their", "complexity", "and", "role", "in", "energy", "conversion"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416596", "name": "C1416596#ent", "pos": [8, 9]}}
{"token": ["Twenty-one", "young", "female", "patients", "are", "described", "who", "presented", "with", "amenorrhoea", ",", "C0235660#ent", "<e1>", "or", "infertility", ",", "and", "were", "treated", "by", "C0032002#ent", "<e2>", "20,000", "rads", "."], "h": {"id": "C0235660", "name": "C0235660#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [20, 21]}}
{"token": ["Acute", "interstitial", "pneumonia", "AIP", ")", "and", "acute", "exacerbations", "C0085786#ent", "<e1>", "AEIPF", ")", "are", "similar", "C0035242#ent", "<e2>", "characterized", "by", "the", "rapid", "development", "of", "progressive", "dyspnea", "and", "cough", "."], "h": {"id": "C0085786", "name": "C0085786#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [14, 15]}}
{"token": ["We", "describe", "in", "this", "report", "the", "isolation", "and", "characterization", "of", "a", "murine", "C1334043#ent", "<e1>", "of", "human", "C1413978#ent", "<e2>", "hBD-2", ")", "called", "mouse", "beta-defensin", "3", "mBD-3", ")", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1413978", "name": "C1413978#ent", "pos": [16, 17]}}
{"token": ["To", "describe", "a", "child", "with", "a", "craniopharyngioma", "and", "C0030353#ent", "<e1>", "who", "developed", "a", "unilateral", "epiretinal", "membrane", "C3273434#ent", "<e2>", ")", "after", "completing", "radiation", "therapy", "his", "tumor", "."], "h": {"id": "C0030353", "name": "C0030353#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3273434", "name": "C3273434#ent", "pos": [16, 17]}}
{"token": ["A", "33-year-old", "woman", "admitted", "for", "C0025309#ent", "<e1>", "had", "features", "of", "C0014040#ent", "<e2>", "on", "her", "third", "day", "of", "illness", "."], "h": {"id": "C0025309", "name": "C0025309#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014040", "name": "C0014040#ent", "pos": [10, 11]}}
{"token": ["Symptoms", "and", "signs", "of", "sick", "sinus", "syndrome", "C0012833#ent", "<e1>", ",", "palpitation", ",", "syncope", "and", "peripheral", "or", "C0007780#ent", "<e2>"], "h": {"id": "C0012833", "name": "C0012833#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007780", "name": "C0007780#ent", "pos": [16, 17]}}
{"token": ["According", "to", "morphometric", "analysis", "the", "C0085648#ent", "<e1>", "the", "number", "of", "ganglion", "cells", "significantly", "smaller", "in", "both", "the", "C0362046#ent", "<e2>", "and", "the", "diabetic", "animals", "than", "in", "the", "age-matched", "control", "Wistar", "rats"], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [17, 18]}}
{"token": ["All", "patients", "were", "randomized", "except", "for", "63", "with", "known", "C0018799#ent", "<e1>", "were", "assigned", "to", "regimen", "1", "(", "to", "avoid", "C0085752#ent", "<e2>", ")", "and", "studied", "separately", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [19, 20]}}
{"token": ["There", "is", "controversy", "regarding", "the", "possible", "role", "of", "glial", "cells", "C0033036#ent", "<e1>", "in", "the", "pathogenesis", "of", "central", "nervous", "system", "CNS", ")", "C0011303#ent", "<e2>", "as", "multiple", "sclerosis", "its", "animal", "model", "experimental", "autoimmune", "encephalomyelitis", "EAE", ")", "."], "h": {"id": "C0033036", "name": "C0033036#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011303", "name": "C0011303#ent", "pos": [21, 22]}}
{"token": ["The", "effect", "of", "aspirin", "on", "normal", "and", "C0008354#ent", "<e1>", "toxin-stimulated", "electrolyte", "transport", "has", "been", "investigated", "in", "vitro", "because", "this", "C1254351#ent", "<e2>", "appears", "to", "inhibit", "C0008354#ent", "<e1>", "toxin-induced", "intestinal", "secretion", "in", "in", "vivo", "animal", "models"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0008354", "name": "C0008354#ent", "pos": [7, 8]}}
{"token": ["The", "complex", "retroviruses", "a", "C3273437#ent", "<e1>", "uses", "a", "leucine-rich", "NES", "interact", "with", "C1421544#ent", "<e2>", "and", "the", "U", "snRNA-export", "pathway", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421544", "name": "C1421544#ent", "pos": [12, 13]}}
{"token": ["We", "report", "on", "the", "clinical", ",", "pathological", ",", "and", "C1517495#ent", "<e1>", "7", "patients", "with", "C1869123#ent", "<e2>", "LGMD2A", ")", "from", "three", "Japanese", "families", "."], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1869123", "name": "C1869123#ent", "pos": [14, 15]}}
{"token": ["On", "the", "following", "day", "she", "developed", "C0013404#ent", "<e1>", ",", "tachycardia", ",", "hypotension", "and", "rising", "C0004002#ent", "<e2>", "levels", "."], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004002", "name": "C0004002#ent", "pos": [14, 15]}}
{"token": ["We", "report", "a", "brother", "and", "sister", ",", "both", "of", "whom", "have", "C0151860#ent", "<e1>", ",", "hydrocephalus", ",", "optic", "atrophy", "severe", "mental", "retardation", "and", "C0034372#ent", "<e2>"], "h": {"id": "C0151860", "name": "C0151860#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0034372", "name": "C0034372#ent", "pos": [22, 23]}}
{"token": ["Loss", "of", "membrane", "E-cadherin", "expression", "was", "consistently", "found", "in", "all", "nine", "cases", "with", "C1428414#ent", "<e1>", "mutation", ",", "suggesting", "that", "tumors", "inactivated", "the", "remaining", "C1428414#ent", "<e1>", "C1706112#ent", "<e1>", "via", "a", "different", "mechanism", "."], "h": {"id": "C1428414", "name": "C1428414#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [25, 26]}}
{"token": ["We", "also", "can", "evaluate", "the", "fraction", "of", "low", "protein", "content", "cells", "(", "C3273549#ent", "<e1>", "fraction", ")", "that", "seems", "to", "be", "the", "C1822658#ent", "<e2>", "and", "early", "G1", "fraction", "."], "h": {"id": "C3273549", "name": "C3273549#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1822658", "name": "C1822658#ent", "pos": [21, 22]}}
{"token": ["If", "adopted", "for", "such", "use", ",", "this", "C1254351#ent", "<e1>", "might", "be", "helpful", "in", "protecting", "against", "the", "development", "of", "C0004153#ent", "<e2>", "and", "microvascular", "complications", "via", "its", "improvement", "of", "insulin", "resistance"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [18, 19]}}
{"token": ["Preoperative", "diagnoses", "were", "C0029408#ent", "<e1>", "(", "OA", ")", ",", "37", ";", "osteonecrosis", "(", "C2985244#ent", "<e2>", ")", ",", "six", ";", "dysplasia", ",", "nine", ";", "rheumatoid", "ankylosing", "spondylitis", "three", ";", "and", "other", ",", "two", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2985244", "name": "C2985244#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "the", "C0043194#ent", "<e1>", "locus", "lies", "within", "the", "pericentric", "region", "of", "the", "X", "chromosome", "provide", "an", "initial", "step", "toward", "identifying", "the", "C1421478#ent", "<e2>", "improving", "the", "genetic", "counseling", "C0043194#ent", "<e1>", "families", "."], "h": {"id": "C1421478", "name": "C1421478#ent", "pos": [24, 25]}, "relation": "gene_associated_with_disease", "t": {"id": "C0043194", "name": "C0043194#ent", "pos": [5, 6]}}
{"token": ["The", "objective", "of", "our", "study", "was", "to", "describe", "the", "occurrence", "of", "local", "complications", "and", "the", "C1539479#ent", "<e1>", "of", "fluid", "collections", "in", "milder", "forms", "of", "C0267941#ent", "<e2>"], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0267941", "name": "C0267941#ent", "pos": [24, 25]}}
{"token": ["C1424697#ent", "<e1>", "-", "72", "markedly", "elevated", "the", "C1337092#ent", "<e2>", "mRNA", "levels", "in", "brain", "tissue"], "h": {"id": "C1424697", "name": "C1424697#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337092", "name": "C1337092#ent", "pos": [7, 8]}}
{"token": ["Etidronate", "is", "less", "effective", "than", "other", "C0012544#ent", "<e1>", ",", "such", "as", "alendronate", "and", "C0246719#ent", "<e2>", ",", "in", "reduction", "of", "fracture", "risk", "especially", "non-vertebral", "fracture", "although", "bone", "mineral", "density", "femoral", "neck", "significantly", "increased", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [6, 7]}, "relation": "structural_class_of", "t": {"id": "C0246719", "name": "C0246719#ent", "pos": [13, 14]}}
{"token": ["It", "was", "concluded", "that", "dobutamine", "and", "dipyridamole", "stress", "echocardiography", "similar", "sensitivities", "and", "specificities", "for", "detection", "of", "C0010054#ent", "<e1>", "coronary", "artery", "disease", "the", "haemodynamic", "effects", "the", "two", "C0035064#ent", "<e2>", "are", "different", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [26, 27]}}
{"token": ["Routine", "clinical", "evaluation", "often", "includes", "the", "determination", "of", "serum", "tumor", "markers", "AFP", ",", "CA19", "-", "9", ",", "CEA", ",", "C2346918#ent", "<e1>", ",", "CA15-3", "PSA", ",", "and", "C1367551#ent", "<e2>", "."], "h": {"id": "C2346918", "name": "C2346918#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1367551", "name": "C1367551#ent", "pos": [26, 27]}}
{"token": ["Proteins", "that", "increased", "in", "abundance", "included", "authophagy-linked", "microtubule-associated", "protein", "light", "chain", "3", "C1417005#ent", "<e1>", ")", ",", "synapsin-1", ",", "and", "Parkinsonism", "linked", "ubiquitin", "carboxy-terminal", "hydroxylase-L1", "C3541328#ent", "<e2>", ")", "."], "h": {"id": "C1417005", "name": "C1417005#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3541328", "name": "C3541328#ent", "pos": [24, 25]}}
{"token": ["Caterpillar", "spicule", "venoms", "were", "extracted", "and", "studied", "for", "the", "following", "activities", ":", "arginine", "ester", "BAEE", ")", "C1334064#ent", "<e1>", ",", "tyrosine", "ester", "ATEE", ")", "hydrolase", ",", "C1947941#ent", "<e2>", "(", "casein", "digestion", "and", "phospholipase", "A", "indirect", "hemolytic", "activity", "."], "h": {"id": "C1334064", "name": "C1334064#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [25, 26]}}
{"token": ["In", "all", "regions", "C0917713#ent", "<e1>", "was", "unrelated", "to", "dose", "or", "duration", "of", "C0038317#ent", "<e2>", "treatment", "."], "h": {"id": "C0917713", "name": "C0917713#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [12, 13]}}
{"token": ["Of", "interest", ",", "MEKK1", "immunoprecipitates", "from", "IL-1-stimulated", "FLS", "appeared", "to", "activate", "c-Jun", "through", "the", "JNK", "pathway", "C1417830#ent", "<e1>", "activation", "of", "c-Jun", "was", "dependent", "on", "JNK", ",", "C1705791#ent", "<e2>", ",", "and", "p38", "."], "h": {"id": "C1417830", "name": "C1417830#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [26, 27]}}
{"token": ["However", ",", "SP", "and", "C1704715#ent", "<e1>", "did", "not", "stimulate", "bovine", "C1860224#ent", "<e2>", "."], "h": {"id": "C1704715", "name": "C1704715#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1860224", "name": "C1860224#ent", "pos": [10, 11]}}
{"token": ["Some", "C3889446#ent", "<e1>", "genes", ",", "such", "as", "S100A4", ",", "prostate", "stem", "cell", "antigen", "carcinoembryonic", "antigen-related", "cell", "adhesion", "molecule", "6", "and", "C1334533#ent", "<e2>", ",", "suggest", "potential", "use", "as", "diagnostic", "markers"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334533", "name": "C1334533#ent", "pos": [20, 21]}}
{"token": ["Thus", "a", "deletion", "in", "one", "allele", "of", "the", "C1334133#ent", "<e1>", "be", "at", "least", "partly", "responsible", "for", "some", "instances", "of", "C0854110#ent", "<e2>"], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0854110", "name": "C0854110#ent", "pos": [19, 20]}}
{"token": ["The", "ability", "of", "the", "differentiating", "C0142812#ent", "<e1>", "NaB", ")", "to", "modulate", "total", "C1414426#ent", "<e2>", "activity", "was", "also", "examined", "."], "h": {"id": "C0142812", "name": "C0142812#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414426", "name": "C1414426#ent", "pos": [12, 13]}}
{"token": ["Voltammetric", "selectivity", "measurements", "revealed", "negligible", "interferences", "from", "C0012091#ent", "<e1>", "family", "of", "anti-inflammatory", "drugs", "such", "as", "niflumic", "or", "C0025042#ent", "<e2>"], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025042", "name": "C0025042#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "reported", "that", "the", "genomic", "lotus", "of", "C1420884#ent", "<e1>", "also", "transcribes", "a", "natural", "antisense", "transcript", "C0124604#ent", "<e2>", ")", "with", "an", "overlapping", "and", "reverse", "complement", "region", "against", "C1420884#ent", "<e1>", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1420884", "name": "C1420884#ent", "pos": [8, 9]}}
{"token": ["This", "study", "has", "shown", "C0018801#ent", "<e1>", "be", "as", "well", "controlled", "by", "once-daily", "C0072857#ent", "<e2>", "as", "by", "twice-daily", "captopril", ",", "with", "comparable", "effects", "on", "first-dose", "blood-pressure", "response", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0072857", "name": "C0072857#ent", "pos": [12, 13]}}
{"token": ["The", "phosphorylation", "of", "two", "C4284026#ent", "<e1>", "increased", "by", "C0282210#ent", "<e2>", "(", "Mr", "20,500", "and", "22,500", ")", ",", "as", "was", "an", "Mr", "31,000", "protein", "which", "was", "probably", "the", "S6", "ribosomal", "protein"], "h": {"id": "C4284026", "name": "C4284026#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [8, 9]}}
{"token": ["Chlamydia", "pneumoniae", "an", "important", "human", "respiratory", "pathogen", "is", "responsible", "for", "an", "estimated", "10", "%", "of", "C0694549#ent", "<e1>", "5", "%", "of", "bronchitis", "and", "C0037199#ent", "<e2>", "cases", "."], "h": {"id": "C0694549", "name": "C0694549#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [22, 23]}}
{"token": ["Interestingly", ",", "both", "stimuli", "induced", "the", "expression", "of", "the", "Fas", "receptor", "but", "with", "different", "kinetics", ",", "while", "the", "C1515370#ent", "<e1>", "FasL", ")", "was", "expressed", "C0669365#ent", "<e2>", "in", "SPGM-1", "cells", "."], "h": {"id": "C1515370", "name": "C1515370#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [24, 25]}}
{"token": ["C1515370#ent", "<e1>", "FasL", ")", ",", "an", "apoptosis-inducing", "cytokine", "is", "C0669365#ent", "<e2>", "expressed", "on", "endothelial", "cells", "EC", ")", "."], "h": {"id": "C1515370", "name": "C1515370#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [9, 10]}}
{"token": ["These", "data", "suggest", "that", "CSD", "promotes", "the", "expression", "of", "C1968833#ent", "<e1>", ",", "HIF-1alpha", ",", "and", "LDH-A", "in", "C0027769#ent", "<e2>", "a", "neuroprotective", "effect"], "h": {"id": "C1968833", "name": "C1968833#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027769", "name": "C0027769#ent", "pos": [17, 18]}}
{"token": ["To", "investigate", "the", "relationship", "between", "C0520680#ent", "<e1>", "SDB", ")", "and", "C0085580#ent", "<e2>", "a", "population", "of", "older", "male", "hypertensives", "."], "h": {"id": "C0520680", "name": "C0520680#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085580", "name": "C0085580#ent", "pos": [10, 11]}}
{"token": ["C0600311#ent", "<e1>", "administered", "to", "ouabain-intoxicated", "dogs", "to", "determine", "an", "C0003195#ent", "<e2>", "plasma", "concentration", "of", "procainamide", "."], "h": {"id": "C0600311", "name": "C0600311#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [9, 10]}}
{"token": ["We", "evaluate", "the", "potential", "role", "of", "direct", "thrombin", "inhibitors", "patients", "with", "C0035086#ent", "<e1>", "have", "acute", "coronary", "syndromes", "with", "particular", "focus", "on", "the", "clinical", "efficacy", "C0168273#ent", "<e2>", "."], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0168273", "name": "C0168273#ent", "pos": [24, 25]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "investigate", "the", "presence", "of", "anti-AADC", "antibodies", "a", "large", "cohort", "of", "patients", "with", "C0085859#ent", "<e1>", "and", "in", "patients", "with", "isolated", "insulin-dependent", "diabetes", "mellitus", "C0011854#ent", "<e2>", ")", "."], "h": {"id": "C0085859", "name": "C0085859#ent", "pos": [20, 21]}, "relation": "has_manifestation", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [30, 31]}}
{"token": ["These", "results", "indicate", "that", "TRAF2", "and", "C1420889#ent", "<e1>", "are", "involved", "in", "NF-kappaB", "and", "SAPK/JNK", "activation", "by", "CD27", ",", "and", "NIK", "is", "a", "common", "downstream", "kinase", "TRAF2", "and", "C1420889#ent", "<e1>", "for", "NF-kappaB", "and", "C0380051#ent", "<e1>"], "h": {"id": "C1420889", "name": "C1420889#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [32, 33]}}
{"token": ["However", ",", "two", "patients", "(", "one", "from", "Kenya", "and", "the", "other", "from", "Somalia", ")", "whose", "illness", "met", "the", "C0019104#ent", "<e1>", "case", "definition", "virus", "isolates", "were", "not", "C0035613#ent", "<e2>", "."], "h": {"id": "C0019104", "name": "C0019104#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0035613", "name": "C0035613#ent", "pos": [26, 27]}}
{"token": ["All-trans", "retinoic", "acid", "C0003873#ent", "<e1>", ")", "can", "be", "catabolized", "to", "polar", "metabolites", "microsomal", "P450s", "C0534137#ent", "<e2>", ")", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [14, 15]}}
{"token": ["The", "C0298973#ent", "<e1>", "characterized", "with", "respect", "to", "C0084378#ent", "<e2>", "nucleic", "acid-dependent", "ATPase", ",", "and", "RNA", "binding", "."], "h": {"id": "C0298973", "name": "C0298973#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0084378", "name": "C0084378#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "indicate", "that", "C1849718#ent", "<e1>", "is", "a", "partial", "C0243192#ent", "<e2>", "for", "the", "TXA2/endoperoxide", "receptors", "."], "h": {"id": "C1849718", "name": "C1849718#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [9, 10]}}
{"token": ["It", "can", "present", "with", "unusual", "forms", "of", "conjunctivitis", ",", "keratitis", ",", "C0262576#ent", "<e1>", "optic", "nerve", "disease", "uveitis", ",", "vitritis", ",", "and", "other", "forms", "of", "C0029400#ent", "<e2>"], "h": {"id": "C0262576", "name": "C0262576#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029400", "name": "C0029400#ent", "pos": [24, 25]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "compare", "the", "concurrent", "use", "of", "C0008161#ent", "<e1>", "CH", ")", ",", "intramuscular", "C0702208#ent", "<e2>", "(", "IMN", ")", "and", "intravenous", "Nembutal", "IVN", ")", "for", "sedation", "."], "h": {"id": "C0008161", "name": "C0008161#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0702208", "name": "C0702208#ent", "pos": [18, 19]}}
{"token": ["The", "C1254351#ent", "<e1>", "had", "similar", "efficacy", "to", "equivalent-dosage", "SC", "C0724579#ent", "<e2>", "orthopaedic", "surgery"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0724579", "name": "C0724579#ent", "pos": [9, 10]}}
{"token": ["A", "high", "prevalence", "of", "antibodies", "to", "the", "polymerase", "gene", "products", "p65", "and", "C1412677#ent", "<e1>", ")", "and", "to", "a", "C1416479#ent", "<e2>", "which", "is", "not", "yet", "fully", "defined", ",", "was", "also", "noted", "."], "h": {"id": "C1412677", "name": "C1412677#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416479", "name": "C1416479#ent", "pos": [18, 19]}}
{"token": ["Despite", "the", "unchanging", "APD80", "and", "CV", ",", "a", "decrease", "in", "Kv4.3", "expression", "and", "an", "increase", "in", "NCX", "expression", "were", "observed", "in", "C0919550#ent", "<e1>", "compared", "with", "non-paced", "C0872351#ent", "<e2>", "."], "h": {"id": "C0919550", "name": "C0919550#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [26, 27]}}
{"token": ["C2936788#ent", "<e1>", "which", "prazosin", "belongs", "are", "potent", "C0042402#ent", "<e2>"], "h": {"id": "C2936788", "name": "C2936788#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "a", "correlation", "between", "Fos", "expression", "and", "the", "C0170168#ent", "<e1>", "initiation", "of", "DNA", "synthesis", "a", "correlation", "between", "high", "levels", "of", "C0086661#ent", "<e2>", "mRNA", "and", "Src", "kinase", "activity", "the", "regulation", "of", "cell", "migration"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [22, 23]}}
{"token": ["Thus", ",", "calmodulin", "and", "the", "heat-labile", "calmodulin-binding", "protein", "play", "a", "role", "in", "the", "nervous", "system", "the", "site", "of", "C0243051#ent", "<e1>", "action", "and", "at", "the", "level", "of", "C0003379#ent", "<e2>"], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0003379", "name": "C0003379#ent", "pos": [26, 27]}}
{"token": ["As", "for", "C0086661#ent", "<e1>", ",", "PMA", "and", "C1414504#ent", "<e2>", "synergistically", "increased", "expression", "of", "the", "PDGF", "A-chain", "under", "conditions", "where", "PMA", "inhibits", "thrombin-induced", "DNA", "synthesis", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [7, 8]}}
{"token": ["The", "expressed", "C1423607#ent", "<e1>", "existed", "in", "the", "form", "of", "inclusion", "bodies", "was", "purified", "by", "C1705077#ent", "<e2>", "under", "denaturation", "condition"], "h": {"id": "C1423607", "name": "C1423607#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705077", "name": "C1705077#ent", "pos": [14, 15]}}
{"token": ["The", "effectiveness", "and", "tolerance", "of", "C0051162#ent", "<e1>", "and", "metopimazine", "used", "to", "treat", "vomiting", "induced", "by", "C0009450#ent", "<e2>", "evaluated", "in", "47", "infants", "and", "children", "seen", "in", "five", "hospitals", "."], "h": {"id": "C0051162", "name": "C0051162#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "alpha-MSH", "significantly", "upregulated", "C1538975#ent", "<e1>", "mRNA", "expression", ",", "suggesting", "that", "the", "C0003620#ent", "<e2>", "alpha-MSH", "is", "mediated", "by", "C1538975#ent", "<e1>", "."], "h": {"id": "C1538975", "name": "C1538975#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [14, 15]}}
{"token": ["To", "evaluate", "C1333497#ent", "<e1>", "quantitative", "real-time", "reverse-transcriptase", "polymerase", "chain", "reaction", "applied", "for", "collagen", "I", "collagen", "II", "biglycan", ",", "C1413930#ent", "<e2>", ",", "fibromodulin", ",", "fibronectin", ",", "aggrecan", ",", "and", "osteonectin", "."], "h": {"id": "C1333497", "name": "C1333497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413930", "name": "C1413930#ent", "pos": [18, 19]}}
{"token": ["To", "quantify", "and", "evaluate", "the", "distribution", "of", "angiotensin", "II", "C3273406#ent", "<e1>", "and", "its", "receptors", "in", "the", "C1421355#ent", "<e2>"], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421355", "name": "C1421355#ent", "pos": [16, 17]}}
{"token": ["We", "studied", "the", "efficacy", "and", "safety", "of", "the", "drug", "in", "113", "pediatric", "patients", "with", "mild-to-moderate", "bacterial", "C0005943#ent", "<e1>", "upper", "respiratory", "tract", "infection", "pharyngitis", "or", "tonsillitis", ")", ",", "C0149514#ent", "<e2>", "otitis", "media", "urinary", "tract", "infection", "UTI", ")", "."], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [27, 28]}}
{"token": ["Among", "the", "examined", "group", ",", "the", "most", "frequently", "occurring", "C0005943#ent", "<e1>", "infections", "of", "the", "ureter", ",", "C0149514#ent", "<e2>", ",", "flu", "and", "ear", "infection"], "h": {"id": "C0005943", "name": "C0005943#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [16, 17]}}
{"token": ["The", "influence", "of", "doxapram", "(", "a", "C0282685#ent", "<e1>", "pretreatment", "on", "C0030883#ent", "<e2>", "mice", "was", "assessed", "by", "measurements", "of", "sleeping", "times", "hypothermia", ",", "LD50", "values", ",", "hepatic", "microsomal", "metabolism", "relative", "plasma", "and", "brain", "levels", "pentobarbital", "."], "h": {"id": "C0282685", "name": "C0282685#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [10, 11]}}
{"token": ["We", "discuss", "recent", "data", "demonstrating", "that", "in", "macrophages", ",", "cytosolic", "Francisella", "induce", "the", "activation", "of", "the", "C2717970#ent", "<e1>", "caspase-1", "within", "a", "C0751283#ent", "<e2>", "the", "inflammasome", "."], "h": {"id": "C2717970", "name": "C2717970#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0751283", "name": "C0751283#ent", "pos": [21, 22]}}
{"token": ["After", "4", "and", "18", "hr", "of", "incubation", "of", "the", "Clara", "cells", "major", "radiolabelled", "C1313497#ent", "<e1>", "those", "with", "molecular", "weights", "6", ",", "48", ",", "and", "180", "C1705240#ent", "<e2>", "."], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [25, 26]}}
{"token": ["The", "demonstration", "of", "4-hydroxyisovaleric", "acid", "the", "contention", "that", "urinary", "methylsuccinic", "acid", "seen", "in", "patients", "with", "C0268575#ent", "<e1>", "arisen", "by", "omega-oxidation", "of", "C0268575#ent", "<e1>"], "h": {"id": "C0268575", "name": "C0268575#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0268575", "name": "C0268575#ent", "pos": [15, 16]}}
{"token": ["The", "evaluating", "the", "cause", "of", "death", "within", "two", "years", "after", "first", "treatment", ",", "C0162557#ent", "<e1>", "more", "common", "in", "patients", "treated", "with", "C0071449#ent", "<e2>", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0071449", "name": "C0071449#ent", "pos": [21, 22]}}
{"token": ["No", "further", "decrease", "of", "C0018834#ent", "<e1>", "was", "observed", "when", "the", "dose", "of", "C0028978#ent", "<e2>", "was", "doubled", "to", "60", "mg/day", ",", "or", "after", "a", "second", "week", "of", "treatment", "with", "30", "mg/day", "."], "h": {"id": "C0018834", "name": "C0018834#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [12, 13]}}
{"token": ["Regulation", "of", "substance", "P", "receptor", "C1420565#ent", "<e1>", ")", "mRNA", "was", "examined", "in", "the", "rat", "sympathetic", "superior", "cervical", "ganglion", "C0012694#ent", "<e2>", ")", "in", "vitro", "in", "vivo", "axotomy", "."], "h": {"id": "C1420565", "name": "C1420565#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [18, 19]}}
{"token": ["Second", ",", "xIAP", "can", "inhibit", "cell", "proliferation", "downregulation", "of", "cyclins", "A", "C3889128#ent", "<e1>", "and", "induction", "of", "the", "cyclin-dependent", "kinase", "inhibitors", "p21(Cip1/Waf1", ")", "and", "C1332737#ent", "<e2>", ")", "."], "h": {"id": "C3889128", "name": "C3889128#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [23, 24]}}
{"token": ["The", "current", "study", "investigated", "the", "effect", "of", "C0700541#ent", "<e1>", "on", "spinal", "dorsal", "horn", "neurons", "excited", "by", "urinary", "bladder", "distension", "C1425779#ent", "<e2>", ")", "."], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1425779", "name": "C1425779#ent", "pos": [19, 20]}}
{"token": ["Restoration", "of", "C0285590#ent", "<e1>", "expression", "in", "Colo", "205", "cells", "induced", "C1414157#ent", "<e2>", "mRNA", "and", "protein", "and", "the", "formation", "of", "desmosomes", "."], "h": {"id": "C0285590", "name": "C0285590#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414157", "name": "C1414157#ent", "pos": [10, 11]}}
{"token": ["Recent", "findings", "suggest", "that", "the", "pathway", "involving", "bone", "mineral", "effects", "is", "important", "for", "the", "development", "of", "C0001342#ent", "<e1>", ",", "but", "their", "effects", "of", "combined", "C0919430#ent", "<e2>", "polymorphisms", "have", "not", "been", "confirmed", "on", "C0001342#ent", "<e1>", "."], "h": {"id": "C0001342", "name": "C0001342#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0919430", "name": "C0919430#ent", "pos": [24, 25]}}
{"token": ["The", "inhibition", "of", "C0608437#ent", "<e1>", "be", "a", "possible", "explanation", "for", "the", "drug-drug", "interaction", "C0039286#ent", "<e2>", "with", "CYP2C9", "substrates"], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [3, 4]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "identify", "a", "centrosomal", "C3896756#ent", "<e1>", "substrate", ",", "termed", "C1865069#ent", "<e2>", "(", "ninein-like", "protein", ",", "whose", "properties", "suggest", "an", "important", "role", "in", "microtubule", "organization"], "h": {"id": "C3896756", "name": "C3896756#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1865069", "name": "C1865069#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "the", "efficacy", "of", "C0085174#ent", "<e1>", "for", "the", "prevention", "of", "nonsteroidal", "anti-inflammatory", "drug", "duodenal", "and", "C0038358#ent", "<e2>", "arthritis", "patients", "receiving", "NSAID", "therapy", "."], "h": {"id": "C0085174", "name": "C0085174#ent", "pos": [5, 6]}, "relation": "may_prevent", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [16, 17]}}
{"token": ["We", "maintain", "that", "in", "each", "C0019693#ent", "<e1>", "infected", "patient", ",", "with", "or", "without", "C0006840#ent", "<e2>", "who", "shows", "dysphonia", ",", "candidiasic", "laryngitis", "be", "ruled", "out", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [13, 14]}}
{"token": ["In", "this", "note", ",", "the", "effect", "of", "fenticonazole", "on", "secretory", "aspartic", "proteinase", "the", "human", "C0029118#ent", "<e1>", "Candida", "albicans", "shown", ",", "in", "a", "comparison", "with", "C0013547#ent", "<e2>", "."], "h": {"id": "C0029118", "name": "C0029118#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013547", "name": "C0013547#ent", "pos": [24, 25]}}
{"token": ["These", "findings", "throw", "the", "spotlight", "on", "HBV", "infection", "and", "syphilis", "and", "suggest", "that", "these", "two", "C0036916#ent", "<e1>", "infections", "should", "be", "carefully", "surveyed", "in", "patients", "with", "C0497169#ent", "<e2>", "in", "Jamaica", "."], "h": {"id": "C0036916", "name": "C0036916#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0497169", "name": "C0497169#ent", "pos": [25, 26]}}
{"token": ["These", "data", "suggest", "a", "novel", "role", "for", "ICAM-1", "in", "modulating", "VEGF-A-induced", "angiogenesis", "and", "C1328053#ent", "<e1>", "activity", "through", "regulation", "of", "C1430988#ent", "<e2>", "expression", "via", "modulation", "of", "intracellular", "GSH", "status", "."], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [19, 20]}}
{"token": ["C1412276#ent", "<e1>", "from", "patients", "with", "various", "bullous", "diseases", "the", "same", "polypeptides", "thus", "suggesting", "that", "the", "presence", "of", "C1412276#ent", "<e1>", "can", "not", "be", "regarded", "as", "a", "serological", "marker", "C1832586#ent", "<e1>", "."], "h": {"id": "C1412276", "name": "C1412276#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1832586", "name": "C1832586#ent", "pos": [27, 28]}}
{"token": ["The", "C0013227#ent", "<e1>", "is", "an", "C2267010#ent", "<e2>", "a", "S2", "and", "alpha", "1", "receptor", "antagonist", "this", "action", "favors", "a", "blood", "pressure", "reduction", "due", "to", "a", "decrease", "of", "peripheral", "resistances"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2267010", "name": "C2267010#ent", "pos": [5, 6]}}
{"token": ["They", "are", "fatal", "neurodegenerative", "diseases", "include", "\"", "scrapie", "\"", "in", "sheep", ",", "Creutzfeldt-Jakob", "disease", "C2347435#ent", "<e1>", ")", "and", "kuru", "in", "humans", ",", "and", "C1135993#ent", "<e2>", "deers", "."], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1135993", "name": "C1135993#ent", "pos": [23, 24]}}
{"token": ["We", "have", "determined", "the", "crystal", "structures", "HA-1077", ",", "H-1152P", ",", "and", "C0667301#ent", "<e1>", "in", "complexes", "with", "C0033640#ent", "<e2>", "PKA", ")", "as", "a", "surrogate", "kinase", "to", "analyze", "Rho-kinase", "inhibitor", "binding", "properties", "."], "h": {"id": "C0667301", "name": "C0667301#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [16, 17]}}
{"token": ["The", "mutational", "specificities", "DNA", "cross-linking", "compounds", "such", "as", "cisplatin", ",", "transplatin", ",", "C0079083#ent", "<e1>", ",", "mitomycin", "C", "psoralen", ",", "and", "8-methoxypsoralen", "were", "investigated", "in", "C0022959#ent", "<e2>", "reversion", "assay", "systems", "of", "Escherichia", "coli"], "h": {"id": "C0079083", "name": "C0079083#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022959", "name": "C0022959#ent", "pos": [24, 25]}}
{"token": ["Regulation", "of", "gastric", "acid", "secretion", "by", "acid-inhibitory", "drugs", "has", "been", "shown", "to", "decrease", "acute", "C1319853#ent", "<e1>", "varying", "extents", ",", "depending", "on", "the", "C0013227#ent", "<e2>", "used", "and", "the", "method", "of", "assessing", "mucosal", "damage"], "h": {"id": "C1319853", "name": "C1319853#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [22, 23]}}
{"token": ["Treatment", "of", "C1319853#ent", "<e1>", "be", "to", "discontinue", "the", "C0013227#ent", "<e2>", ",", "or", "at", "least", ",", "to", "reduce", "the", "dose", "as", "much", "as", "possible", "."], "h": {"id": "C1319853", "name": "C1319853#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}}
{"token": ["After", "C4049865#ent", "<e1>", "committed", "to", "differentiation", ",", "the", "synthesis", "of", "complex", "C0017083#ent", "<e2>", "was", "elevated", "more", "than", "20-fold", ",", "coinciding", "with", "the", "stage", "of", "neurite", "outgrowth"], "h": {"id": "C4049865", "name": "C4049865#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017083", "name": "C0017083#ent", "pos": [11, 12]}}
{"token": ["The", "C1420439#ent", "<e1>", "proto-oncoprotein", "(", "also", "known", "as", "C3273634#ent", "<e2>", ")", "is", "a", "gene", "expression", "conserved", "across", "species", "."], "h": {"id": "C1420439", "name": "C1420439#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273634", "name": "C3273634#ent", "pos": [8, 9]}}
{"token": ["The", "results", "demonstrate", "that", "expression", "of", "C1826766#ent", "<e1>", "in", "oropharyngeal", "SCC", "down-regulated", "active", "rap1", ",", "C1705791#ent", "<e2>", "activation", ",", "and", "proliferation", "."], "h": {"id": "C1826766", "name": "C1826766#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "the", "possible", "presence", "of", "small", "amounts", "C0015505#ent", "<e1>", "some", "concentrates", ",", "but", "differences", "in", "C1336938#ent", "<e2>", "content", "could", "also", "contribute", "towards", "the", "different", "rates", "of", "factor", "Xa", "generation", "observed", "."], "h": {"id": "C0015505", "name": "C0015505#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [17, 18]}}
{"token": ["Numerous", "factors", "should", "be", "considered", "when", "prescribing", "medications", "from", "an", "ever-growing", "antidepressant", "armamentarium", ",", "including", "selective", "serotonin-reuptake", "inhibitors", "C0162758#ent", "<e1>", "serotonin", "antagonist-reuptake", "inhibitors", "norepinephrine", "dopamine", "modulators", "monoamine", "oxidase", "inhibitors", "reversible", "inhibitors", "of", "C0026455#ent", "<e2>", "tricyclic", "antidepressants", "and", "psychostimulants", "."], "h": {"id": "C0162758", "name": "C0162758#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0026455", "name": "C0026455#ent", "pos": [32, 33]}}
{"token": ["The", "C1259497#ent", "<e1>", "(", "UGTs", ")", "are", "C0021699#ent", "<e2>", "the", "endoplasmic", "reticulum", "play", "important", "roles", "in", "the", "defense", "against", "potentially", "hazardous", "xenobiotics", "."], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [1, 2]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [7, 8]}}
{"token": ["The", "p53-family", "of", "C0086376#ent", "<e1>", ",", "including", "p53", ",", "p63", ",", "and", "C0812244#ent", "<e2>", ",", "shares", "a", "high", "degree", "of", "structural", "similarity", "and", "can", "carry", "out", "some", "redundant", "functions", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812244", "name": "C0812244#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "C0022860#ent", "<e1>", ",", "diltiazem", "and", "verapamil", "on", "C0003420#ent", "<e2>", "and", "indocyanine", "green", "clearance", "were", "evaluated", "in", "a", "placebo-controlled", ",", "repeated", "measures", "evaluation", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003420", "name": "C0003420#ent", "pos": [10, 11]}}
{"token": ["We", "now", "report", "that", "two", "C0001645#ent", "<e1>", "of", "arachidonic", "acid", "metabolism", "indomethacin", "and", "C0000546#ent", "<e2>", "inhibit", "this", "arachidonic", "acid-mediated", "response"], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000546", "name": "C0000546#ent", "pos": [13, 14]}}
{"token": ["The", "AMBP", "[", "A1M", "precursor", "]", "gene", "encodes", "C0072522#ent", "<e1>", "A1M", "an", "immunosuppressive", "lipocalin", "and", "bikunin", ",", "a", "member", "of", "C2717971#ent", "<e2>", "family", "with", "prototypical", "Kunitz-type", "domain"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [20, 21]}}
{"token": ["The", "C3540471#ent", "<e1>", "was", "to", "investigate", "the", "influence", "of", "amine", "fluoride", "fluoride", "(", "C1335843#ent", "<e2>", ")", "containing", "toothpaste", "and", "mouthrinse", "on", "plaque", "accumulation", "and", "gingival", "health", "young", "adults", "4", "weeks", "use", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1335843", "name": "C1335843#ent", "pos": [13, 14]}}
{"token": ["The", "OSNs", "expressed", "a", "diversity", "of", "C0935996#ent", "<e1>", "including", "stomatin", "(", "Epb7.2", ")", ",", "S100A5", ",", "C1413947#ent", "<e2>", ",", "Sirt2", ",", "CD81", ",", "Sdc2", ",", "Omp", ",", "and", "Ptpla", "."], "h": {"id": "C0935996", "name": "C0935996#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413947", "name": "C1413947#ent", "pos": [16, 17]}}
{"token": ["In", "our", "studies", "in", "SAMP1/Yit", "mice", ",", "the", "aim", "was", "to", "investigate", "whether", "C1367307#ent", "<e1>", "activation", "contributes", "to", "C0020877#ent", "<e2>", "and", "to", "examine", "the", "therapeutic", "effects", "this", "signal", "blockade", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020877", "name": "C0020877#ent", "pos": [18, 19]}}
{"token": ["When", "the", "mammalian", "C1334043#ent", "<e1>", "of", "S.", "pombe", "C1419245#ent", "<e2>", "was", "inactivated", ",", "however", ",", "chromosomal", "instability", "observed", "even", "in", "the", "absence", "of", "DNA", "damaging", "agents"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419245", "name": "C1419245#ent", "pos": [8, 9]}}
{"token": ["In", "the", "absence", "of", "C2744579#ent", "<e1>", ",", "where", "the", "head-to-tail", "polymerization", "mechanism", "was", "not", "operative", "C1414292#ent", "<e2>", "brought", "about", "by", "the", "slow", "process", "of", "length", "fluctuation", "polymers", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414292", "name": "C1414292#ent", "pos": [15, 16]}}
{"token": ["Acute", "exacerbations", "C0026769#ent", "<e1>", "MS", ")", "are", "commonly", "treated", "with", "high", "doses", "C3539185#ent", "<e2>", "that", "can", "influence", "sleep", "regulation", "hypothalamo-pituitary-adrenal", "(HPA)", "activity", "."], "h": {"id": "C0026769", "name": "C0026769#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539185", "name": "C3539185#ent", "pos": [12, 13]}}
{"token": ["The", "present", "study", "sought", "to", "determine", "the", "effect", "of", "C0311989#ent", "<e1>", ",", "the", "product", "of", "the", "reaction", "catalyzed", "by", "C1872855#ent", "<e2>", "on", "ornithine", "decarboxylase", "activity", "."], "h": {"id": "C0311989", "name": "C0311989#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1872855", "name": "C1872855#ent", "pos": [19, 20]}}
{"token": ["These", "observations", "indicate", "that", "C1423775#ent", "<e1>", "is", "implicated", "in", "membrane", "association", "C1333571#ent", "<e2>", ",", "but", "not", "that", "of", "COPI", ",", "through", "activating", "ARF", "."], "h": {"id": "C1423775", "name": "C1423775#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [11, 12]}}
{"token": ["The", "present", "experiments", "were", "designed", "to", "test", "the", "hypothesis", "that", "prostaglandin", "(", "C1868501#ent", "<e1>", ")", "E(2", ")", "causes", "vasodilatation", "through", "activation", "of", "endothelial", "NO", "synthase", "C1328053#ent", "<e2>", ")", "."], "h": {"id": "C1868501", "name": "C1868501#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [25, 26]}}
{"token": ["In", "a", "subsequent", "double-blind", "study", "it", "was", "attempted", "for", "the", "first", "time", "to", "determine", "the", "efficacy", "of", "C0009010#ent", "<e1>", "compared", "to", "that", "of", "acetylsalicylic", "acid", "48", "patients", "with", "C0030193#ent", "<e2>", "mono-", "and", "polyneuropathies", "."], "h": {"id": "C0009010", "name": "C0009010#ent", "pos": [17, 18]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [28, 29]}}
{"token": ["At", "7", "weeks", ",", "DD", "C3815598#ent", "<e1>", "of", "both", "strains", "showed", "significantly", "decreased", "isometric", "twitch", "and", "C0039614#ent", "<e2>", "tensions", "compared", "with", "their", "non-DD", "controls", "."], "h": {"id": "C3815598", "name": "C3815598#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039614", "name": "C0039614#ent", "pos": [16, 17]}}
{"token": ["Chromatin-associated", "high", "mobility", "group", "HMG", ")", "C0086376#ent", "<e1>", "of", "the", "C1333911#ent", "<e2>", "versatile", "architectural", "factors", "various", "DNA-dependent", "processes", "as", "transcription", "and", "recombination", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333911", "name": "C1333911#ent", "pos": [10, 11]}}
{"token": ["C3887685#ent", "<e1>", "is", "an", "important", "intermediate", "enzyme", "in", "metabolism", "of", "C0002600#ent", "<e2>", "to", "nortriptyline", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [0, 1]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [10, 11]}}
{"token": ["In", "a", "series", "of", "202", "postmortem", "toxicology", "cases", ",", "the", "C3887685#ent", "<e1>", "and", "CYP2C19", "genes", "genotyped", ",", "and", "the", "concentrations", "of", "C0002600#ent", "<e2>", "(", "AT", ")", "and", "six", "metabolites", "were", "analyzed", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [10, 11]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [21, 22]}}
{"token": ["HCV", "core-induced", "impairment", "of", "C0752312#ent", "<e1>", "in", "the", "inhibition", "of", "C1522405#ent", "<e2>", "and", "IL-2Ralpha", "gene", "transcription", ",", "which", "led", "to", "the", "inhibition", "of", "C1522405#ent", "<e2>", "production", "and", "high-affinity", "IL-2R", "expression", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [10, 11]}}
{"token": ["The", "genes", "for", "Klebsiella", "aerogenes", "K.", "pneumoniae", "C0041945#ent", "<e1>", "were", "cloned", "and", "the", "protein", "was", "C3889446#ent", "<e2>", "(", "up", "to", "18", "%", "of", "total", "protein", "of", "this", "enzyme", ")", "in", "several", "hosts", "."], "h": {"id": "C0041945", "name": "C0041945#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [15, 16]}}
{"token": ["C1880991#ent", "<e1>", "embedded", "tissues", "used", "to", "localize", "C1412239#ent", "<e2>", "activity", "in", "the", "rat", "respiratory", "tract", "kidney", ",", "liver", ",", "and", "brain", "."], "h": {"id": "C1880991", "name": "C1880991#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412239", "name": "C1412239#ent", "pos": [7, 8]}}
{"token": ["C1414962#ent", "<e1>", "exists", "in", "the", "Golgi", "complex", "similar", "to", "many", "other", "C1333828#ent", "<e2>", ",", "as", "well", "as", "on", "the", "cell", "surface", "where", "it", "functions", "as", "a", "signaling", "receptor", "extracellular", "glycoside", "ligands", "."], "h": {"id": "C1414962", "name": "C1414962#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "target", "or", "acceptor", "molecules", "C1418773#ent", "<e1>", "appear", "to", "be", "coded", "for", "by", "C0017337#ent", "<e2>", "within", "the", "H-2", "K", "and", "H-2D", "loci", "."], "h": {"id": "C1418773", "name": "C1418773#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["To", "explore", "whether", "striatal", "dopamine", "transporters", "involved", "in", "C0751383#ent", "<e1>", "JNCL", ")", "with", "C0234133#ent", "<e2>"], "h": {"id": "C0751383", "name": "C0751383#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [13, 14]}}
{"token": ["Sucralphate", ",", "an", "aluminium", "hydroxide", "complex", "C0038633#ent", "<e1>", "in", "the", "treatment", "of", "C0038358#ent", "<e2>", "seems", "to", "be", "of", "value", "in", "preventing", "radiation-induced", "bowel", "discomfort", "."], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [12, 13]}}
{"token": ["We", "investigated", "the", "effect", "of", "C0038633#ent", "<e1>", "on", "angiogenesis", "in", "granulation", "tissue", "C0038358#ent", "<e2>", "induced", "by", "acetic", "acid", "rats", "using", "the", "carmine", "dye", "method", "."], "h": {"id": "C0038633", "name": "C0038633#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [12, 13]}}
{"token": ["C0263666#ent", "<e1>", "also", "occur", "as", "part", "of", "other", "C0751871#ent", "<e2>", "as", "scleroderma", "and", "systemic", "lupus", "erythematosus"], "h": {"id": "C0263666", "name": "C0263666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751871", "name": "C0751871#ent", "pos": [8, 9]}}
{"token": ["This", "study", "determined", "the", "cost", "effectiveness", "of", "adding", "salmeterol", "(", "S", ")", "or", "C0939232#ent", "<e1>", "(", "FS", ")", "to", "tiotropium", "(", "T", ")", "for", "C1647218#ent", "<e2>", "."], "h": {"id": "C0939232", "name": "C0939232#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [24, 25]}}
{"token": ["Here", ",", "we", "present", "a", "new", "model", "of", "EC", "migration", "and", "morphogenesis", "within", "three-dimensional", "C3889469#ent", "<e1>", "termed", "\"", "radial", "invasion", "matrix", "by", "aggregated", "cells", "\"", "(", "C1705077#ent", "<e2>", ")", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705077", "name": "C1705077#ent", "pos": [26, 27]}}
{"token": ["In", "this", "study", ",", "we", "have", "identified", "C1419781#ent", "<e1>", ",", "but", "not", "calmodulin", "or", "other", "C3274824#ent", "<e2>", "as", "a", "potent", "molecular", "chaperone", "a", "new", "member", "of", "the", "multichaperone", "complex"], "h": {"id": "C1419781", "name": "C1419781#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3274824", "name": "C3274824#ent", "pos": [15, 16]}}
{"token": ["If", "anything", ",", "Bosentan", "enhanced", "the", "C0013604#ent", "<e1>", "formation", "in", "parallel", "with", "increased", "ET-1-LI", "in", "C1704942#ent", "<e2>", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [15, 16]}}
{"token": ["C1333574#ent", "<e1>", "stimulates", "increased", "guanine", "nucleotide-binding", "protein", "C0060916#ent", "<e2>", "activation", "in", "IFN-M", "as", "evidenced", "by", "enhanced", "guanosine", "5'-[gamma-thio]triphosphate", "binding", "and", "GTPase", "activity"], "h": {"id": "C1333574", "name": "C1333574#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0060916", "name": "C0060916#ent", "pos": [7, 8]}}
{"token": ["C3536873#ent", "<e1>", "IgG", ")", "purified", "from", "C0796085#ent", "<e2>", "was", "shown", "to", "be", "the", "blocking", "agent"], "h": {"id": "C3536873", "name": "C3536873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0796085", "name": "C0796085#ent", "pos": [6, 7]}}
{"token": ["Using", "a", "novel", "expression", "cloning", "strategy", "recently", "developed", "to", "identify", "cDNAs", "encoding", "caspase", "substrates", ",", "we", "isolated", "the", "C1415042#ent", "<e1>", "vimentin", "as", "a", "C0534519#ent", "<e2>"], "h": {"id": "C1415042", "name": "C1415042#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [23, 24]}}
{"token": ["While", "the", "human", "genome", "has", "138", "pseudogenes", "related", "to", "K8", "and", "C3829362#ent", "<e1>", ",", "the", "mouse", "and", "rat", "C0242965#ent", "<e2>", "contain", "only", "4", "and", "6", "such", "pseudogenes", "."], "h": {"id": "C3829362", "name": "C3829362#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [18, 19]}}
{"token": ["This", "C1848862#ent", "<e1>", "can", "develop", "into", "the", "more", "complex", "and", "disabling", ",", "C0039585#ent", "<e2>", "so", "preventing", "early", "exposure", "to", "toxins", "at", "home", "is", "critical", "in", "reducing", "the", "likelihood", "of", "health", "problems", "the", "community", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0039585", "name": "C0039585#ent", "pos": [12, 13]}}
{"token": ["The", "C1848862#ent", "<e1>", "of", "androgen", "insensitivity", ",", "a", "paradigm", "of", "a", "C0039585#ent", "<e2>", "manifests", "as", "failure", "of", "masculinization", "despite", "normal", "or", "high", "concentrations", "of", "serum", "testosterone"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0039585", "name": "C0039585#ent", "pos": [11, 12]}}
{"token": ["To", "study", "the", "regulation", "of", "C1413505#ent", "<e1>", "expression", ",", "we", "have", "first", "isolated", "the", "C0079429#ent", "<e2>", "for", "human", "C1413505#ent", "<e1>", "from", "a", "cosmid", "library", "a", "cDNA", "probe"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413505", "name": "C1413505#ent", "pos": [5, 6]}}
{"token": ["In", "the", "absence", "of", "the", "IFN-gamma-inducible", "proteasome", "subunits", "LMP2", "and", "C3811068#ent", "<e1>", ",", "the", "trypsin-like", "(", "but", "not", "the", "C0008742#ent", "<e2>", "of", "the", "proteasome", "is", "directly", "related", "to", "MHC", "class", "I", "peptide", "loading", "."], "h": {"id": "C3811068", "name": "C3811068#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008742", "name": "C0008742#ent", "pos": [19, 20]}}
{"token": ["Both", "the", "human", "pregnane", "X", "receptor", "hPXR", ")", "and", "constitutive", "androstane", "receptor", "C3540475#ent", "<e1>", ")", "are", "capable", "of", "regulating", "C1142644#ent", "<e2>", "and", "CYP2B6", "gene", "expression", "."], "h": {"id": "C3540475", "name": "C3540475#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "show", "that", "the", "polycomb", "group", "protein", "Pc2", "binds", "to", "and", "colocalizes", "with", "C1447702#ent", "<e1>", "HIPK2", ")", "and", "serves", "as", "a", "SUMO", "E3", "ligase", "this", "C0031727#ent", "<e2>", "."], "h": {"id": "C1447702", "name": "C1447702#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [26, 27]}}
{"token": ["PCR/restriction-enzyme", "analysis", "in", "chimpanzees", "revealed", "an", "APOE", "profile", "similar", "to", "the", "human", "C2827465#ent", "<e1>", "associated", "with", "increased", "risk", "of", "C0002395#ent", "<e2>"], "h": {"id": "C2827465", "name": "C2827465#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [19, 20]}}
{"token": ["C1427643#ent", "<e1>", "and", "prostate", "epithelium-specific", "C1426033#ent", "<e2>", "expression", "is", "regulated", "by", "a", "proximal", "promoter", "and", "an", "upstream", "enhancer", "several", "androgen", "receptor", "binding", "sites"], "h": {"id": "C1427643", "name": "C1427643#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1426033", "name": "C1426033#ent", "pos": [5, 6]}}
{"token": ["PRL", "synthesis", "stimulated", "by", "the", "C0220821#ent", "<e1>", "agonist", "R5417", "or", "thyrotropin", "releasing", "hormone", "C1705225#ent", "<e2>", ")", "was", "also", "inhibited", "."], "h": {"id": "C0220821", "name": "C0220821#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [13, 14]}}
{"token": ["In", "populations", "exposed", "to", "Leishmania", "braziliensis", "certain", "subjects", "develop", "C0037299#ent", "<e1>", "whereas", "others", "are", "naturally", "protected", "against", "C0276878#ent", "<e2>"], "h": {"id": "C0037299", "name": "C0037299#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0276878", "name": "C0276878#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "we", "investigated", "whether", "the", "Raf1", ",", "Mdm2", ",", "c-Myc", ",", "Cdc25a", "and", "C1413258#ent", "<e1>", "proto-oncogenes", ",", "which", "are", "implicated", "in", "the", "ras", "or", "C1705526#ent", "<e2>", "or", "pRb", "pathways", "are", "alternative", "oncogenic", "target", "genes"], "h": {"id": "C1413258", "name": "C1413258#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [25, 26]}}
{"token": ["C0029408#ent", "<e1>", "the", "acromioclavicular", "joint", "found", "in", "all", "cases", ",", "whereas", "C0151434#ent", "<e2>", "noted", "in", "less", "than", "half", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0151434", "name": "C0151434#ent", "pos": [11, 12]}}
{"token": ["However", ",", "procarbazine", "failed", "to", "exert", "this", "effect", "after", "the", "C3541394#ent", "<e1>", "had", "been", "induced", "by", "continuous", "administration", "C0700349#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0700349", "name": "C0700349#ent", "pos": [18, 19]}}
{"token": ["Blocking", "of", "murine", "C1416397#ent", "<e1>", "with", "the", "neutralizing", "antibody", "inhibits", "response", "of", "mouse", "thymoma", "cells", "BMD", "mast", "cells", "C3540587#ent", "<e2>", "."], "h": {"id": "C1416397", "name": "C1416397#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540587", "name": "C3540587#ent", "pos": [18, 19]}}
{"token": ["Mechanistically", ",", "C0012582#ent", "<e1>", "induced", "transcriptional", "shutdown", "of", "C1332416#ent", "<e2>", "expression", "accompanying", "G(1", ")", "arrest", "that", "was", "characterized", "by", "downregulation", "of", "D-type", "cyclins", "and", "cdk6", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [8, 9]}}
{"token": ["Equal", "performance", "for", "C1415692#ent", "<e1>", "and", "LP", "items", "would", "indicate", "C0004303#ent", "<e2>"], "h": {"id": "C1415692", "name": "C1415692#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004303", "name": "C0004303#ent", "pos": [10, 11]}}
{"token": ["C1417215#ent", "<e1>", "SP-D", "was", "partially", "digested", "by", "human", "leukocyte", "elastase", "C3538705#ent", "<e2>", ")", "dose-", "and", "time-dependently", "."], "h": {"id": "C1417215", "name": "C1417215#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538705", "name": "C3538705#ent", "pos": [10, 11]}}
{"token": ["C0020640#ent", "<e1>", "is", "one", "of", "the", "most", "significant", "haematological", "abnormalities", "C3844565#ent", "<e2>", "."], "h": {"id": "C0020640", "name": "C0020640#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3844565", "name": "C3844565#ent", "pos": [10, 11]}}
{"token": ["In", "this", "stage", ",", "the", "activation", "of", "proteolytic", "enzymes", "such", "as", "C0030946#ent", "<e1>", "of", "the", "plasmin", "system", "serine", "proteinases", "and", "matrix", "metalloproteinases", "C0623362#ent", "<e2>", ")", ",", "is", "necessary", "."], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [22, 23]}}
{"token": ["C1415254#ent", "<e1>", "of", "DWA2114R", "by", "the", "serial", "administration", "higher", "than", "that", "of", "C0079083#ent", "<e2>", "at", "the", "doses", "to", "induce", "the", "same", "toxicity", "which", "was", "estimated", "by", "body", "weight", "loss"], "h": {"id": "C1415254", "name": "C1415254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [12, 13]}}
{"token": ["The", "patient", "also", "had", "C0022680#ent", "<e1>", "Potter", "type", "3", ")", "with", "C0221155#ent", "<e2>"], "h": {"id": "C0022680", "name": "C0022680#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0221155", "name": "C0221155#ent", "pos": [11, 12]}}
{"token": ["Both", "GE", "inhibitions", "and", "C1418224#ent", "<e1>", "accelerations", "by", "C0014838#ent", "<e2>", "Ia-IIb", "(", "25", "mg/kg", ")", "were", "markedly", "attenuated", "by", "pretreatment", "with", "indomethacin", "(", "10", "mg/kg", ",", "s.c", ".", ","], "h": {"id": "C1418224", "name": "C1418224#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014838", "name": "C0014838#ent", "pos": [8, 9]}}
{"token": ["The", "myositis", "syndromes", "the", "most", "common", "forms", "of", "which", "are", "C0011633#ent", "<e1>", "and", "dermatomyositis", ",", "are", "defined", "by", "C0085270#ent", "<e2>", "skeletal", "muscle"], "h": {"id": "C0011633", "name": "C0011633#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085270", "name": "C0085270#ent", "pos": [18, 19]}}
{"token": ["Hepatic", "disease", "C0003873#ent", "<e1>", "not", "significantly", "alter", "the", "disposition", "of", "C0069739#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0069739", "name": "C0069739#ent", "pos": [10, 11]}}
{"token": ["The", "C0031727#ent", "<e1>", "a", "distinct", "bias", "for", "S-MCT", ",", "while", "C0012892#ent", "<e2>", "exclusively", "incorporate", "the", "North", "5'-triphosphate", "N-MCT-TP", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [1, 2]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [10, 11]}}
{"token": ["The", "C1424580#ent", "<e1>", "null", "mutant", "strains", "were", "avirulent", "in", "a", "mouse", "model", "C0006840#ent", "<e2>"], "h": {"id": "C1424580", "name": "C1424580#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0006840", "name": "C0006840#ent", "pos": [12, 13]}}
{"token": ["We", "have", "purified", "and", "characterized", "two", "C0012906#ent", "<e1>", "the", "saprophyte", "Mycobacterium", "chelonei", "C0406810#ent", "<e2>", "82", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0406810", "name": "C0406810#ent", "pos": [12, 13]}}
{"token": ["These", "experiments", "demonstrate", "that", "C1172344#ent", "<e1>", "has", "cytotoxic", "activity", "all", "B-cell", "lines", "tested", ",", "regardless", "of", "C0149678#ent", "<e2>", "status", "or", "Bcl-2", "and", "Bcl-x(L", ")", "expression", "levels"], "h": {"id": "C1172344", "name": "C1172344#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [16, 17]}}
{"token": ["Silencing", "of", "C1428414#ent", "<e1>", "by", "RNA", "interference", "in", "G1", "cells", "stabilizes", "Skp2", "and", "C1425999#ent", "<e2>", ",", "with", "a", "consequent", "increase", "in", "p21", "and", "p27", "proteolysis", "."], "h": {"id": "C1428414", "name": "C1428414#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1425999", "name": "C1425999#ent", "pos": [13, 14]}}
{"token": ["These", "results", "reveal", "the", "biochemical", "mechanism", "underlying", "the", "essential", "signaling", "function", "of", "C1416380#ent", "<e1>", "and", "provide", "direct", "evidence", "that", "signal-induced", "site-specific", "ubiquitination", "of", "C1421371#ent", "<e2>", "is", "required", "for", "IKK", "activation", "."], "h": {"id": "C1416380", "name": "C1416380#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421371", "name": "C1421371#ent", "pos": [23, 24]}}
{"token": ["The", "present", "study", "tested", "the", "hypothesis", "that", "C1539778#ent", "<e1>", "plays", "a", "crucial", "role", "in", "[Ca2+]i", "overload", "and", "C1706544#ent", "<e2>", "synthesis", "in", "CMECs", "."], "h": {"id": "C1539778", "name": "C1539778#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706544", "name": "C1706544#ent", "pos": [17, 18]}}
{"token": ["Delayed-type", "hypersensitivity", "DTH", ")", "reaction", "to", "C1367475#ent", "<e1>", "was", "increased", "to", "normal", "levels", "by", "the", "combination", "of", "C0221055#ent", "<e2>", "and", "ethanol", ",", "compared", "with", "the", "treatment", "of", "ethanol", "alone", "."], "h": {"id": "C1367475", "name": "C1367475#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221055", "name": "C0221055#ent", "pos": [17, 18]}}
{"token": ["Activation", "of", "the", "C1307407#ent", "<e1>", "pathway", ",", "which", "is", "probably", "mediated", "by", "PAR1", "and/or", "C1539608#ent", "<e2>", ",", "was", "associated", "with", "enhanced", "cell", "migration", "a", "key", "step", "in", "the", "metastatic", "cascade"], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539608", "name": "C1539608#ent", "pos": [14, 15]}}
{"token": ["Virus", "recoveries", "based", "on", "cell", "culture", "infectivity", "were", "25", "to", "35", "%", "for", "C1422123#ent", "<e1>", "and", "5", "to", "10", "%", "for", "C0019159#ent", "<e2>", "."], "h": {"id": "C1422123", "name": "C1422123#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [21, 22]}}
{"token": ["Virus", "recoveries", "in", "secondary", "PEG", "concentrates", "ranged", "from", "10", "to", "70", "%", "for", "C1422123#ent", "<e1>", "and", "2", "to", "4", "%", "for", "C0019159#ent", "<e2>", "as", "evaluated", "by", "mammalian", "cell", "culture", "assay", "."], "h": {"id": "C1422123", "name": "C1422123#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [21, 22]}}
{"token": ["However", ",", "the", "immunopathologic", "findings", "are", "distinctive", "enough", "to", "be", "useful", "in", "differentiating", "the", "porphyrias", "and", "C0521616#ent", "<e1>", "other", "subepidermal", "bullous", "diseases", "as", "C0079293#ent", "<e2>", "bullous", "pemphigoid"], "h": {"id": "C0521616", "name": "C0521616#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0079293", "name": "C0079293#ent", "pos": [23, 24]}}
{"token": ["Laboratory", "investigations", "significant", "C0002871#ent", "<e1>", ",", "reticulocytosis", "and", "indirect", "C0022350#ent", "<e2>", "among", "the", "index", "newborns", "compared", "with", "controls", "(", "p", "<", "0.001", ")", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022350", "name": "C0022350#ent", "pos": [9, 10]}}
{"token": ["One", "comprises", "C1413394#ent", "<e1>", ",", "REP2", "and", "REP5", ",", "and", "the", "other", "C1423875#ent", "<e2>", "and", "REP4", "."], "h": {"id": "C1413394", "name": "C1413394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1423875", "name": "C1423875#ent", "pos": [12, 13]}}
{"token": ["The", "most", "commonly", "occurring", "manifestations", "were", ":", "C0013595#ent", "<e1>", "and", "dermatitis", ",", "C0032285#ent", "<e2>", ",", "upper", "respiratory", "tract", "infections", "cutaneous", "abscesses", "diarrhoea", ",", "deep", "abscesses", "and", "otitis", "media"], "h": {"id": "C0013595", "name": "C0013595#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032285", "name": "C0032285#ent", "pos": [12, 13]}}
{"token": ["The", "rates", "of", "C1420645#ent", "<e1>", "and", "deprenyl", "N-demethylation", "by", "rat", "C0111863#ent", "<e2>", "and", "2C13", "were", "far", "greater", "than", "those", "of", "the", "reactions", "at", "other", "N-alpha-positions", "."], "h": {"id": "C1420645", "name": "C1420645#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0111863", "name": "C0111863#ent", "pos": [10, 11]}}
{"token": ["For", "fifteen", "years", "oral", "C0008809#ent", "<e1>", "has", "been", "the", "standard", "treatment", "C0029878#ent", "<e2>", "a", "sometimes", "fatal", "osteomyelitis", "of", "the", "skull", "base", "caused", "by", "Pseudomonas", "aeruginosa"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0029878", "name": "C0029878#ent", "pos": [11, 12]}}
{"token": ["1H", "and", "13C", "NMR", "shifts", "for", "catechin", "gallate", "C3540479#ent", "<e1>", ")", ",", "EGC", ",", "ECG", ",", "C0059438#ent", "<e2>", "and", "epigallocatechin", "3,5-di-O-gallate", "EGCDG", ")", "in", "CD3OD", "were", "also", "recorded", "."], "h": {"id": "C3540479", "name": "C3540479#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059438", "name": "C0059438#ent", "pos": [16, 17]}}
{"token": ["The", "preponderance", "of", "data", "supports", "the", "safety", "of", "C0002934#ent", "<e1>", "such", "patients", ",", "and", "these", "C0991617#ent", "<e2>", "should", "not", "be", "withheld", "from", "persons", "at", "risk", "for", "developing", "the", "syndrome", "."], "h": {"id": "C0002934", "name": "C0002934#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [15, 16]}}
{"token": ["C1332667#ent", "<e1>", "activity", "increased", "in", "the", "C0206157#ent", "<e2>", "group", "."], "h": {"id": "C1332667", "name": "C1332667#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0206157", "name": "C0206157#ent", "pos": [6, 7]}}
{"token": ["We", "recommend", "the", "use", "of", "intermittent", "oral", "cyclosporin", "for", "recurrent", ",", "C3714552#ent", "<e1>", "episodes", "of", "C0014742#ent", "<e2>"], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014742", "name": "C0014742#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "determine", "whether", "pitavastatin", ",", "a", "newly", "developed", "statin", ",", "modulates", "the", "urinary", "C1706127#ent", "<e1>", "levels", "in", "normolipidemic", "patients", "with", "C1561643#ent", "<e2>", "."], "h": {"id": "C1706127", "name": "C1706127#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [27, 28]}}
{"token": ["We", "present", "two", "patients", "with", "exercise-induced", "bundle", "branch", "block", "(", "C1801950#ent", "<e1>", ")", ",", "in", "which", "C0010054#ent", "<e2>", "not", "be", "diagnosed", "by", "noninvasive", "techniques"], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [16, 17]}}
{"token": ["There", "is", "good", "evidence", "for", "recommending", "the", "use", "of", "oral", "glucocorticoids", "and", "cyclosporin", "for", "the", "treatment", "of", "canine", "C0011615#ent", "<e1>", "and", "fair", "evidence", "for", "using", "C0040864#ent", "<e2>", "topical", "tacrolimus", "lotion", "oral", "pentoxifylline", "oral", "misoprostol"], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0040864", "name": "C0040864#ent", "pos": [25, 26]}}
{"token": ["The", "bacterium", "was", "resistant", "to", "cotrimoxazole", ",", "the", "C0013227#ent", "<e1>", "of", "choice", "for", "C0028242#ent", "<e2>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028242", "name": "C0028242#ent", "pos": [13, 14]}}
{"token": ["The", "group", "I", "mGluRs", "(", "mGlu1", "and", "C1706589#ent", "<e1>", ")", "modulate", "nociceptive", "plasticity", "via", "activation", "of", "C4082284#ent", "<e2>", "ERK", ")", "signaling", "."], "h": {"id": "C1706589", "name": "C1706589#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [16, 17]}}
{"token": ["The", "Melkersson-Rosenthal", "syndrome", "of", "recurrent", "swelling", "the", "C1846919#ent", "<e1>", "or", "face", ",", "intermittent", "C0015469#ent", "<e2>", "and", "fissured", "tongue"], "h": {"id": "C1846919", "name": "C1846919#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015469", "name": "C0015469#ent", "pos": [13, 14]}}
{"token": ["It", "was", "found", "that", "both", "the", "esterase", "and", "C0109060#ent", "<e1>", "activities", "of", "C0002313#ent", "<e2>", "were", "inhibited", "by", "antithrombin", "III", "the", "reactions", "were", "accelerated", "by", "heparin", "."], "h": {"id": "C0109060", "name": "C0109060#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002313", "name": "C0002313#ent", "pos": [12, 13]}}
{"token": ["The", "non-selective", "beta-antagonist", ",", "C0026289#ent", "<e1>", ",", "was", "used", "to", "estimate", "C0001644#ent", "<e2>", "involvement", "."], "h": {"id": "C0026289", "name": "C0026289#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [11, 12]}}
{"token": ["As", "coxsackievirus", "B3", "CoxB3", ")", "and", "adenoviruses", "may", "cause", "acute", "myocarditis", "C0027121#ent", "<e1>", "isolation", "of", "the", "common", "C1413828#ent", "<e2>", "(", "CAR", ")", "has", "provided", "an", "interesting", "new", "target", "for", "molecular", "antiviral", "therapy"], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413828", "name": "C1413828#ent", "pos": [17, 18]}}
{"token": ["The", "1186-bp", "C3890000#ent", "<e1>", "cDNA", "contains", "a", "single", "C0013570#ent", "<e2>", "which", "encodes", "201", "aa", "(", "M(r", ")", "22,601", ")", "."], "h": {"id": "C3890000", "name": "C3890000#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [8, 9]}}
{"token": ["C1412332#ent", "<e1>", "and", "alpha-fetoprotein", "(", "AFP", ")", "are", "members", "of", "a", "C0017363#ent", "<e2>", "also", "includes", "vitamin-D-binding", "protein"], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [11, 12]}}
{"token": ["Sequencing", "of", "the", "11", "exons", "of", "the", "C0017337#ent", "<e1>", "for", "the", "C1416843#ent", "<e2>", "no", "abnormality"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416843", "name": "C1416843#ent", "pos": [11, 12]}}
{"token": ["But", "most", "patients", "revealed", "C0042940#ent", "<e1>", "ventilation", "resistant", "to", "the", "effect", "of", "C0085926#ent", "<e2>"], "h": {"id": "C0042940", "name": "C0042940#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085926", "name": "C0085926#ent", "pos": [12, 13]}}
{"token": ["Over", "the", "last", "decade", ",", "the", "increasing", "use", "of", "serum", "and", "urine", "protein", "screening", "of", "patients", "with", "C0041848#ent", "<e1>", "led", "to", "greater", "recognition", "of", "C0031117#ent", "<e2>", "are", "associated", "with", "monoclonal", "proteins", "plasma", "cell", "."], "h": {"id": "C0041848", "name": "C0041848#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [24, 25]}}
{"token": ["Chronic", "exposure", "to", "C0242293#ent", "<e1>", "(", "a", "high", "efficacy", "C0005064#ent", "<e2>", ")", "elicits", "no", "change", "in", "the", "number", "of", "benzodiazepine", "binding", "sites", "the", "affinity", "of", "benzodiazepine", "binding", "the", "absence", "of", "GABA", "."], "h": {"id": "C0242293", "name": "C0242293#ent", "pos": [3, 4]}, "relation": "has_structural_class", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [9, 10]}}
{"token": ["The", "presence", "of", "C0085078#ent", "<e1>", "as", "lysozyme", "suggest", "that", "C3810618#ent", "<e2>", "are", "lysosomal", "organelle", "participate", "in", "the", "uptake", "of", "vWf", "."], "h": {"id": "C0085078", "name": "C0085078#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3810618", "name": "C3810618#ent", "pos": [9, 10]}}
{"token": ["We", "investigated", "the", "effect", "of", "estrogen", ",", "C0618111#ent", "<e1>", "and", "levormeloxifene", "on", "C1332026#ent", "<e2>", "expression", "."], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332026", "name": "C1332026#ent", "pos": [12, 13]}}
{"token": ["This", "group", "included", "55", "children", "with", "anterior", "uveitis", "59", "with", "C0042167#ent", "<e1>", "and", "three", "with", "C0042164#ent", "<e2>"], "h": {"id": "C0042167", "name": "C0042167#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "it", "was", "shown", "that", "the", "unloaded", "nanoparticles", ",", "by", "mechanisms", "not", "completely", "elucidated", ",", "had", "a", "C0041214#ent", "<e1>", "activity", "similar", "to", "that", "of", "standard", "solutions", "C0002144#ent", "<e2>", "."], "h": {"id": "C0041214", "name": "C0041214#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002144", "name": "C0002144#ent", "pos": [28, 29]}}
{"token": ["Reduction", "in", "corneal", "transparence", "leading", "to", "the", "loss", "of", "sight", "be", "caused", "by", "different", "factors", ",", "such", "as", "eye", "burns", "injuries", ",", "C0022568#ent", "<e1>", ",", "corneal", "ulcers", "primary", "and", "secondary", "dystrophy", "C0022578#ent", "<e2>", ",", "and", "keratoglobus", "."], "h": {"id": "C0022568", "name": "C0022568#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0022578", "name": "C0022578#ent", "pos": [31, 32]}}
{"token": ["PECAM-1(-/-", ")", "neutrophils", "also", "exhibited", "intracellularly", "dislocalized", "Src", "homology", "2", "domain", "phosphatase", "1", "C1335283#ent", "<e1>", ")", "and", "had", "less", "IL-8-induced", "C1384543#ent", "<e2>", "."], "h": {"id": "C1335283", "name": "C1335283#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1384543", "name": "C1384543#ent", "pos": [20, 21]}}
{"token": ["Prospective", "studies", "the", "incidence", "of", "C0024138#ent", "<e1>", "inhibitor/antiphospholipid", "syndromes", "and", "vWF", "C2713546#ent", "<e2>", "are", "needed", "to", "assess", "this", "question", "."], "h": {"id": "C0024138", "name": "C0024138#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [11, 12]}}
{"token": ["This", "C0031667#ent", "<e1>", "discovered", "to", "be", "structurally", "homologous", "to", "lecithin", "cholesterol", "acyltransferase", "C0023194#ent", "<e2>", ")", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023194", "name": "C0023194#ent", "pos": [12, 13]}}
{"token": ["The", "co-existence", "of", "active", "forms", "both", "glycogen", "synthase", "C0917783#ent", "<e1>", "promoted", "by", "C0011777#ent", "<e2>", "leads", "to", "a", "situation", "that", "is", "analogous", "to", "that", "of", "the", "fasted", "liver", "."], "h": {"id": "C0917783", "name": "C0917783#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}}
{"token": ["By", "selecting", "random", "HAP1-binding", "sites", ",", "we", "found", "that", "HAP1", ",", "like", "C3541252#ent", "<e1>", ",", "binds", "to", "two", "C1864172#ent", "<e2>", "triplets", "."], "h": {"id": "C3541252", "name": "C3541252#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1864172", "name": "C1864172#ent", "pos": [18, 19]}}
{"token": ["Pharmacotherapy", ",", "including", "C3540711#ent", "<e1>", ",", "dopaminergic", "depleting", "and", "blocking", "C0991617#ent", "<e2>", ",", "and", "other", "muscle", "relaxants", "be", "used", "alone", "or", "in", "combination", "with", "other", "therapeutic", "interventions"], "h": {"id": "C3540711", "name": "C3540711#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [10, 11]}}
{"token": ["MC", "induced", "C1705633#ent", "<e1>", "MAPK", "activation", "in", "C1705526#ent", "<e2>", "expressing", "cells", "but", "not", "in", "p53-deficient", "cells", ",", "indicating", "that", "the", "C1705633#ent", "<e1>", "MAPK", "activation", "was", "dependent", "on", "early", "C1705526#ent", "<e2>", "activation", "."], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [7, 8]}}
{"token": ["In", "a", "T-cell", "lymphoblastic", "lymphoma", "cell", "line", "HT-1", ",", "the", "TCBA1", "fused", "to", "C1427200#ent", "<e1>", "(", "SUMO-1-specific", "protease", ",", "creating", "a", "C1857982#ent", "<e2>"], "h": {"id": "C1427200", "name": "C1427200#ent", "pos": [13, 14]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1857982", "name": "C1857982#ent", "pos": [21, 22]}}
{"token": ["Bilateral", "endogenous", "endophthalmitis", "in", "the", "setting", "of", "C1142127#ent", "<e1>", "diagnosed", "in", "a", "woman", "with", "C0019034#ent", "<e2>", "presented", "with", "decreased", "vision", ",", "increased", "redness", ",", "burning", "pain", "and", "photophobia", "."], "h": {"id": "C1142127", "name": "C1142127#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019034", "name": "C0019034#ent", "pos": [14, 15]}}
{"token": ["In", "cells", "co-expressing", "high", "levels", "of", "the", "p38(MAPK", ")", "kinase", "(", "C4084906#ent", "<e1>", ")", "together", "with", "the", "C1456380#ent", "<e2>", ")", ",", "a", "significant", "inhibition", "of", "mitogen-induced", "cyclin", "D1", "expression", "was", "observed", "."], "h": {"id": "C4084906", "name": "C4084906#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [17, 18]}}
{"token": ["Patients", "with", "C0024408#ent", "<e1>", "usually", "present", "with", "cerebellar", "ataxia", "external", "ophthalmoplegia", "pyramidal", "and", "C0234133#ent", "<e2>", "and", "muscle", "wasting"], "h": {"id": "C0024408", "name": "C0024408#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [13, 14]}}
{"token": ["Substrate", "specificity", "demonstrated", "that", "the", "serum", "activity", "the", "long-chain", "ester", "C0256103#ent", "<e1>", "and", "the", "long-chain", "primary", "acyl", "group", "of", "C0012262#ent", "<e2>", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012262", "name": "C0012262#ent", "pos": [19, 20]}}
{"token": ["Besides", "C0008286#ent", "<e1>", ",", "N-demethylation", "of", "promazine", ",", "promethazine", "and", "C0041031#ent", "<e2>", "was", "also", "observed", "."], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041031", "name": "C0041031#ent", "pos": [10, 11]}}
{"token": ["NAC", "can", "also", "prevent", "apoptosis", "and", "promote", "cell", "survival", "C4082284#ent", "<e1>", "a", "concept", "useful", "for", "treating", "certain", "C1285162#ent", "<e2>"], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [17, 18]}}
{"token": ["The", "putative", "receptor", "protein", "C1412289#ent", "<e1>", ",", "shares", "closest", "identity", "to", "the", "angiotensin", "receptor", "C1439284#ent", "<e2>", ")", "ranging", "from", "40", "to", "50", "%", "in", "the", "hydrophobic", "TM", "regions", "of", "these", "receptors", "."], "h": {"id": "C1412289", "name": "C1412289#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1439284", "name": "C1439284#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "describe", "C2987134#ent", "<e1>", "(", "dkk-1", ")", ",", "which", "encodes", "C1414057#ent", "<e2>", ",", "a", "secreted", "inducer", "of", "Spemann's", "organizer", "Xenopus", "and", "a", "member", "of", "a", "new", "protein", "family"], "h": {"id": "C2987134", "name": "C2987134#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414057", "name": "C1414057#ent", "pos": [11, 12]}}
{"token": ["An", "increase", "in", "the", "activities", "of", "C0215825#ent", "<e1>", "in", "the", "short", "and", "median", "term", "application", "of", "C0009014#ent", "<e2>", "and", "of", "7-ERO-D", "in", "the", "long", "term", "was", "detected", "."], "h": {"id": "C0215825", "name": "C0215825#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [16, 17]}}
{"token": ["Erdheim-Chester", "disease", "lipoid", "granulomatosis", "is", "a", "rare", "type", "II", "C0019624#ent", "<e1>", "histiocytosis", "with", "C0029166#ent", "<e2>"], "h": {"id": "C0019624", "name": "C0019624#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [13, 14]}}
{"token": ["We", "also", "measured", "the", "urinary", "excretion", "C3536869#ent", "<e1>", "in", "children", "with", "C1704321#ent", "<e2>", "both", "congenital", "and", "acquired", ",", "and", "in", "healthy", "children", "."], "h": {"id": "C3536869", "name": "C3536869#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704321", "name": "C1704321#ent", "pos": [11, 12]}}
{"token": ["The", "C0597336#ent", "<e1>", "on", "chromosome", "11", "its", "associated", "epistatic", "TST-QTL", "on", "chromosome", "X", "C0242898#ent", "<e2>", "GABA(A", ")", ")", "receptor", "subunits", "candidates", "."], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [13, 14]}}
{"token": ["Analysis", "of", "a", "chimeric", "construct", "C1422009#ent", "<e1>", "and", "the", "C1447020#ent", "<e2>", "revealed", "that", "C1422009#ent", "<e1>", "palmitoylation", "is", "not", "dependent", "on", "its", "transmembrane", "domain"], "h": {"id": "C1447020", "name": "C1447020#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422009", "name": "C1422009#ent", "pos": [5, 6]}}
{"token": ["In", "addition", ",", "there", "is", "evidence", "of", "a", "role", "for", "CRF-like", "C0030956#ent", "<e1>", "in", "acute", "and", "protracted", "C1332133#ent", "<e2>", "relapse", "to", "drug-taking", "behavior"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332133", "name": "C1332133#ent", "pos": [17, 18]}}
{"token": ["Two", "mAbs", "formed", "a", "new", "cluster", ",", "WC13", ",", "which", "may", "be", "C1512488#ent", "<e1>", "to", "human", "C1706508#ent", "<e2>", "(", "in", "PC27", ")", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706508", "name": "C1706508#ent", "pos": [16, 17]}}
{"token": ["The", "therapeutic", "activity", "C0700482#ent", "<e1>", "was", "tested", "in", "vivo", "a", "model", "of", "C0021390#ent", "<e2>"], "h": {"id": "C0700482", "name": "C0700482#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [12, 13]}}
{"token": ["Outward", "currents", "were", "not", "seen", "with", "either", "recording", "method", "in", "response", "to", "kainate", "or", "C0080073#ent", "<e1>", ",", "nor", "in", "response", "to", "NMDA", "when", "C0730328#ent", "<e2>", "was", "the", "major", "intracellular", "cation", "."], "h": {"id": "C0080073", "name": "C0080073#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0730328", "name": "C0730328#ent", "pos": [23, 24]}}
{"token": ["Resveratrol", ",", "an", "activator", "of", "Sirt1", ",", "increases", "the", "transcriptional", "activity", "C1333572#ent", "<e1>", "and", "triggers", "C0164786#ent", "<e2>", "phosphorylation", "in", "heart", "."], "h": {"id": "C1333572", "name": "C1333572#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [15, 16]}}
{"token": ["CCK-1", "receptor", "antagonist", "C0065197#ent", "<e1>", "also", "greatly", "decreased", "CCK-8-stimulated", "C0077923#ent", "<e2>", "OLETF", "rat", ",", "which", "indicates", "that", "C0065197#ent", "<e1>", "is", "not", "a", "specific", "CCK-1", "receptor", "antagonist", "."], "h": {"id": "C0077923", "name": "C0077923#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0065197", "name": "C0065197#ent", "pos": [3, 4]}}
{"token": ["The", "lower", "molecular", "weight", "band", "with", "a", "component", "of", "constitutive", "PKC", "activity", "eluting", "from", "C0046079#ent", "<e1>", "cellulose", "that", "was", "defined", "by", "inhibition", "of", "basal", "activity", "C0119104#ent", "<e2>", "H7", "."], "h": {"id": "C0046079", "name": "C0046079#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0119104", "name": "C0119104#ent", "pos": [25, 26]}}
{"token": ["Similarly", ",", "multivariate", "models", "that", "included", "HLA", "mismatch", "C0276253#ent", "<e1>", "community", "acquired", "C0042769#ent", "<e2>", "underlying", "disease", "and", "type", "of", "transplant", "that", "A1", "rejection", "a", "distinct", "risk", "factor", "BOS", "."], "h": {"id": "C0276253", "name": "C0276253#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [12, 13]}}
{"token": ["There", "was", "a", "significant", "positive", "correlation", "between", "anti-erythrocytic", "antibody", "C0812382#ent", "<e1>", "NMS", "as", "well", "as", "C2697656#ent", "<e2>", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [15, 16]}}
{"token": ["Mutations", "in", "the", "gene", "coding", "the", "transmembrane", "receptor", "protein", "Patched", "C0694887#ent", "<e1>", ")", "are", "implicated", "in", "the", "C3899989#ent", "<e2>", "Gorlin", "syndrome", "also", "known", "as", "naevoid", "basal", "cell", "carcinoma", "syndrome", ",", "characterized", "by", "congenital", "abnormalities", "cancer", "predisposition"], "h": {"id": "C0694887", "name": "C0694887#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3899989", "name": "C3899989#ent", "pos": [17, 18]}}
{"token": ["Mucous", "membrane", "pemphigoid", "C0623362#ent", "<e1>", ")", "is", "often", "accompanied", "with", "a", "C0155145#ent", "<e2>", "may", "eventually", "lead", "to", "loss", "of", "vision"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0155145", "name": "C0155145#ent", "pos": [11, 12]}}
{"token": ["Quinidine", ",", "C0006378#ent", "<e1>", "and", "ajmaline", "stimulated", "glycolysis", ",", "C0033216#ent", "<e2>", "was", "inactive", "while", "xylocaine", "and", "propranolol", "inhibited", "it", "."], "h": {"id": "C0006378", "name": "C0006378#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [9, 10]}}
{"token": ["Phorbol", "esters", "induce", "apoptosis", "in", "androgen-sensitive", "LNCaP", "cells", ",", "which", "express", "neutral", "endopeptidase", "C1366499#ent", "<e1>", ")", ",", "but", "not", "in", "androgen-independent", "prostate", "cancer", "C3811118#ent", "<e2>", ")", "cells", ",", "which", "lack", "C1366499#ent", "<e1>", "expression", "."], "h": {"id": "C1366499", "name": "C1366499#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [23, 24]}}
{"token": ["In", "cloning", "of", "the", "C4084714#ent", "<e1>", "we", "found", "a", "binding", "site", "the", "promoter", "for", "the", "C1417825#ent", "<e2>", "FXR", ")", ",", "a", "nuclear", "receptor", "bile", "acids"], "h": {"id": "C4084714", "name": "C4084714#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417825", "name": "C1417825#ent", "pos": [15, 16]}}
{"token": ["We", "report", "a", "case", "of", "unilateral", "anterior", "segment", "necrosis", "associated", "with", "bilateral", "metastatic", "group", "C0014236#ent", "<e1>", "a", "68-year-old", "black", "man", "multiple", "systemic", "disorders", "by", "culture-confirmed", "group", "C", "streptococcal", "septicemia", "C0014118#ent", "<e2>", "."], "h": {"id": "C0014236", "name": "C0014236#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [29, 30]}}
{"token": ["Extracellular", "toxins", "as", "cytolysin", "can", "induce", "tissue", "damage", "shown", "in", "an", "C0014236#ent", "<e1>", "increase", "mortality", "in", "combination", "with", "aggregation", "substance", "an", "C0014118#ent", "<e2>", "model", ",", "and", "cause", "systemic", "toxicity", "in", "a", "murine", "peritonitis", "model", "."], "h": {"id": "C0014236", "name": "C0014236#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014118", "name": "C0014118#ent", "pos": [21, 22]}}
{"token": ["Among", "the", "substances", "included", "are", "steroidal", "and", "peptide", "hormones", "their", "modulators", ",", "stimulants", ",", "glucocorticosteroids", ",", "C2936789#ent", "<e1>", ",", "diuretics", "and", "masking", "agents", ",", "narcotics", ",", "and", "C0006864#ent", "<e2>", "."], "h": {"id": "C2936789", "name": "C2936789#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0006864", "name": "C0006864#ent", "pos": [27, 28]}}
{"token": ["During", "G1", ",", "C1704938#ent", "<e1>", ",", "encoding", "a", "C3539812#ent", "<e2>", "and", "CDC34", ",", "encoding", "a", "ubiquitin-conjugating", "enzyme", "are", "involved", "in", "the", "destruction", "of", "these", "regulators", "."], "h": {"id": "C1704938", "name": "C1704938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539812", "name": "C3539812#ent", "pos": [8, 9]}}
{"token": ["Antibodies", ",", "although", "critical", "for", "host", "defense", "against", "C1096184#ent", "<e1>", "WNV", ")", ",", "can", "both", "neutralize", "and", "enhance", "C0042769#ent", "<e2>"], "h": {"id": "C1096184", "name": "C1096184#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [18, 19]}}
{"token": ["Chronic", "pain", "states", "C0014544#ent", "<e1>", "are", "common", "therapeutic", "targets", "of", "C3494198#ent", "<e2>"], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3494198", "name": "C3494198#ent", "pos": [10, 11]}}
{"token": ["For", "the", "first", "time", ",", "we", "demonstrated", "a", "temporal", "relationship", "between", "C0242666#ent", "<e1>", "antibodies", "to", "protein", "S", "C0398623#ent", "<e2>", ",", "thus", "supporting", "the", "pathogenic", "role", "of", "these", "antibodies", "."], "h": {"id": "C0242666", "name": "C0242666#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [17, 18]}}
{"token": ["The", "study", "of", "liver", "disease", "HIV-infected", "patients", "could", "lead", "to", "a", "better", "understanding", "of", "C0029896#ent", "<e1>", "such", "as", "C0524909#ent", "<e2>", "sclerosing", "cholangitis"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [18, 19]}}
{"token": ["C0026088#ent", "<e1>", "clearly", "improved", "skin", "lesions", "C0011847#ent", "<e2>", "associated", "with", "hypercorticism", "."], "h": {"id": "C0026088", "name": "C0026088#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", ":", "The", "low", "degree", "of", "C3889156#ent", "<e1>", "labelling", "of", "the", "C1423498#ent", "<e2>", "makes", "it", "unlikely", "that", "secretory", "granules", "their", "C3889156#ent", "<e1>", "by", "budding", "from", "HRP-labelled", "cisternae", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3889156", "name": "C3889156#ent", "pos": [9, 10]}}
{"token": ["IL-1", "appears", "to", "increase", "mRNA", "for", "C0042071#ent", "<e1>", "to", "a", "greater", "extent", "than", "does", "C0879590#ent", "<e2>", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [14, 15]}}
{"token": ["Hyperthyroidism", "is", "the", "most", "common", "C0014130#ent", "<e1>", "cats", ",", "and", "C0020676#ent", "<e2>", "is", "the", "most", "common", "C0014130#ent", "<e1>", "dogs", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [5, 6]}}
{"token": ["The", "C1516018#ent", "<e1>", "tissue", "distribution", "of", "propranolol", ",", "pindolol", "and", "C0026289#ent", "<e2>", "were", "investigated", "in", "both", "normotensive", "Sprague-Dawley", "and", "spontaneously", "hypertensive", "rats", "."], "h": {"id": "C1516018", "name": "C1516018#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0026289", "name": "C0026289#ent", "pos": [10, 11]}}
{"token": ["C0030903#ent", "<e1>", "does", "not", "affect", "the", "specific", "activities", "of", "glutamine", "synthetase", "C0017796#ent", "<e2>", ",", "or", "glutamate", "decarboxylase", "it", "inhibits", "those", "of", "glutamate", "dehydrogenase", "aspartate", "aminotransferase", "and", "stimulates", "that", "of", "gamma-aminobutyric", "acid", "GABA", ")", "aminotransferase", "."], "h": {"id": "C0030903", "name": "C0030903#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017796", "name": "C0017796#ent", "pos": [11, 12]}}
{"token": ["EGFR", "ligands", "epiregulin", ",", "amphiregulin", ",", "and", "C1539630#ent", "<e1>", "were", "induced", "by", "RV16", "infection", ",", "and", "inhibition", "of", "C2350349#ent", "<e2>", "responsible", "for", "ligand", "shedding", "partially", "suppressed", "this", "response", "."], "h": {"id": "C1539630", "name": "C1539630#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2350349", "name": "C2350349#ent", "pos": [18, 19]}}
{"token": ["The", "high", "level", "of", "FDDCAs", "that", "were", "found", "suggests", "that", "their", "synthesis", "is", "the", "major", "metabolic", "C1539479#ent", "<e1>", "for", "carbon", "diverted", "from", "cholesterol", "synthesis", "a", "C1414563#ent", "<e2>", "inhibitor", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1414563", "name": "C1414563#ent", "pos": [25, 26]}}
{"token": ["Twenty-eight", "subjects", "were", "normal", "and", "59", "patients", "were", "affected", "by", "carotid", "occlusive", "disease", "C0035309#ent", "<e1>", "and", "without", "macular", "involvement", ",", "and", "C0009782#ent", "<e2>", "treated", "with", "antimalarial", "drugs"], "h": {"id": "C0035309", "name": "C0035309#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009782", "name": "C0009782#ent", "pos": [21, 22]}}
{"token": ["Multiple", "copies", "C3539695#ent", "<e1>", "were", "also", "able", "to", "suppress", "C0016937#ent", "<e2>", "expression", "driven", "by", "the", "CYC1", "promoter", "but", "not", "the", "TEF1", "promoter", "."], "h": {"id": "C3539695", "name": "C3539695#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0016937", "name": "C0016937#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "we", "demonstrate", "that", "C1419798#ent", "<e1>", "mediates", "cellular", "cholesterol", "efflux", "via", "the", "C1412058#ent", "<e2>", "and/or", "SR-BI", "pathway", "in", "a", "similar", "way", "to", "apoA-I."], "h": {"id": "C1419798", "name": "C1419798#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412058", "name": "C1412058#ent", "pos": [14, 15]}}
{"token": ["In", "view", "of", "the", "combination", "of", "profound", "hearing", "loss", "vestibular", "dysfunction", "and", "C0035334#ent", "<e1>", "the", "patients", ",", "we", "classified", "the", "disease", "as", "C1568247#ent", "<e2>", "."], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C1568247", "name": "C1568247#ent", "pos": [22, 23]}}
{"token": ["C0014121#ent", "<e1>", "in", "a", "patient", "with", "C0010346#ent", "<e2>"], "h": {"id": "C0014121", "name": "C0014121#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [6, 7]}}
{"token": ["The", "ability", "of", "C3888148#ent", "<e1>", "to", "induce", "C1846919#ent", "<e2>", "translation", "during", "APR", "depends", "on", "phosphorylation", "of", "C3888148#ent", "<e1>", "."], "h": {"id": "C1846919", "name": "C1846919#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3888148", "name": "C3888148#ent", "pos": [3, 4]}}
{"token": ["These", "findings", "also", "indicate", "that", "selective", "C0162757#ent", "<e1>", "represent", "a", "novel", "C0003289#ent", "<e2>"], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [11, 12]}}
{"token": ["Familial", "SLE", "provides", "a", "unique", "opportunity", "to", "study", "the", "relationships", "of", "previously", "associated", "genetic", "factors", "HLA", "and", "C3150275#ent", "<e1>", "to", "the", "occurrence", "of", "SLE", ",", "other", "C0004364#ent", "<e2>", "and", "autoantibodies", "in", "families", "."], "h": {"id": "C3150275", "name": "C3150275#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [26, 27]}}
{"token": ["In", "many", "cases", ",", "a", "C0072399#ent", "<e1>", "a", "response", "regulator", "encoded", "in", "the", "same", "C0029073#ent", "<e2>", "and", ",", "in", "such", "cases", ",", "the", "two", "molecules", "usually", "interact", "in", "an", "exclusive", "one-to-one", "fashion", "."], "h": {"id": "C0072399", "name": "C0072399#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "examined", "the", "possible", "function", "of", "C1334090#ent", "<e1>", "MPR", ")", "and", "low-density", "lipoprotein-receptor", "related", "protein", "C1539696#ent", "<e2>", ")", ",", "recently", "implicated", "in", "cellular", "uptake", "heparanase", ",", "as", "heparanase", "receptors", "Akt", "phosphorylation", "."], "h": {"id": "C1334090", "name": "C1334090#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [17, 18]}}
{"token": ["The", "addition", "of", "etoposide", "as", "a", "third", "C1254351#ent", "<e1>", "has", "yielded", "C1366489#ent", "<e2>", "rates", "of", ">", "50", "%", ",", "but", "data", "on", "quality", "of", "life", "survival", "time", "not", "been", "reported", "for", "these", "combinations", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366489", "name": "C1366489#ent", "pos": [11, 12]}}
{"token": ["We", "assessed", "four", "patients", "who", "had", "non-small", "cell", "lung", "cancer", "severe", "C0206061#ent", "<e1>", "association", "with", "C1122962#ent", "<e2>", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1122962", "name": "C1122962#ent", "pos": [15, 16]}}
{"token": ["A", "77C", ">", "G", "transversion", "exon", "A", "the", "C1706240#ent", "<e1>", "investigated", "in", "patients", "with", "inflammatory", "bowel", "disease", "C0022104#ent", "<e2>", ")", "and", "controls", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "C1706240#ent", "<e1>", "expression", "by", "C0022104#ent", "<e2>", "IEC", "appears", "to", "be", "altered", ",", "and", "correlates", "with", "a", "functional", "alteration", "of", "lck", "activation", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [6, 7]}}
{"token": ["Silencing", "of", "C0069197#ent", "<e1>", "MGMT", ")", "protein", "expression", "of", "C1334505#ent", "<e2>", "hypermethylation", "is", "considered", "to", "be", "associated", "with", "postoperative", "chemoradiotherapy", "benefits", "in", "glioblastoma", "multiforme", "GBM", ")", "patients", "."], "h": {"id": "C0069197", "name": "C0069197#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334505", "name": "C1334505#ent", "pos": [9, 10]}}
{"token": ["The", "T", "cell", "immunoglobulin", "mucin", "domain", "C1420737#ent", "<e1>", ")", "family", "of", "proteins", "are", "cell", "surface", "proteins", "in", "regulating", "C1423842#ent", "<e2>", "and", "Th2", "immune", "responses"], "h": {"id": "C1420737", "name": "C1420737#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [18, 19]}}
{"token": ["Determination", "of", "C1366480#ent", "<e1>", "L-lactic", "acid", "an", "important", "part", "of", "the", "diagnostic", "setup", "C0263678#ent", "<e2>"], "h": {"id": "C1366480", "name": "C1366480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0263678", "name": "C0263678#ent", "pos": [13, 14]}}
{"token": ["There", "was", "a", "significant", "correlation", "between", "intestinal", "nematodes", "or", "Toxocara", "infection", "C0038160#ent", "<e1>", "children", ",", "reinforced", "by", "higher", "C1306759#ent", "<e2>", "counts", "and", "higher", "IgE", "levels", "in", "these", "children", "than", "in", "the", "control", "group"], "h": {"id": "C0038160", "name": "C0038160#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [18, 19]}}
{"token": ["From", "these", "findings", "it", "is", "concluded", "that", "C0378481#ent", "<e1>", "a", "potent", ",", "competitive", "TXA2/endoperoxide", "receptor", "antagonist", "in", "C1412137#ent", "<e2>"], "h": {"id": "C0378481", "name": "C0378481#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [17, 18]}}
{"token": ["Because", "of", "its", "C0026837#ent", "<e1>", "and", "specificity", ",", "the", "components", "of", "the", "C1420406#ent", "<e2>", "may", "serve", "as", "a", "heuristic", "for", "thinking", "about", "interpersonal", "feedback", "group", "therapy"], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420406", "name": "C1420406#ent", "pos": [12, 13]}}
{"token": ["Differences", "in", "the", "polypeptide", "conformations", "unirradiated", "RNAase", "denatured", "by", "heat", "and", "C0037556#ent", "<e1>", "and", "irradiated", "C0011522#ent", "<e2>", "treated", "with", "heat", "and", "C0037556#ent", "<e1>", "discussed", "."], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0037556", "name": "C0037556#ent", "pos": [11, 12]}}
{"token": ["Infection", "with", "E.", "coli", "O157", "usually", "manifests", "as", "acute", ",", "afebrile", ",", "C0030193#ent", "<e1>", ",", "bloody", "diarrhoea", "is", "the", "commonest", "cause", "of", "C0019061#ent", "<e2>", "HUS", ")", ",", "an", "important", "cause", "of", "childhood", "renal", "failure"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0019061", "name": "C0019061#ent", "pos": [22, 23]}}
{"token": ["C0003892#ent", "<e1>", "also", "know", "as", "Charcot", "joint", "disease", "C0022336#ent", "<e2>", ")", ",", "is", "a", "progressive", ",", "degenerative", "arthropathy", "associated", "with", "types", "of", "neuropathic", "diseases", "however", ",", "diabetes", "mellitus", "the", "leading", "cause", "of", "C0022336#ent", "<e2>", "today", "."], "h": {"id": "C0003892", "name": "C0003892#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022336", "name": "C0022336#ent", "pos": [8, 9]}}
{"token": ["Citrinin", "(", "1.0", "mM", ")", "inhibits", "almost", "all", "C3540772#ent", "<e1>", "linked", "to", "the", "respiratory", "chain", "increases", "the", "activity", "of", "C0038613#ent", "<e2>", "succinate", "oxidase", "coupled", ")", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038613", "name": "C0038613#ent", "pos": [19, 20]}}
{"token": ["The", "effect", "of", "bezafibrate", "on", "serum", "lipids", "lipoproteins", "and", "the", "C0052179#ent", "<e1>", "A-II", "and", "B", "was", "studied", "in", "18", "patients", "with", "C0342879#ent", "<e2>"], "h": {"id": "C0052179", "name": "C0052179#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0342879", "name": "C0342879#ent", "pos": [21, 22]}}
{"token": ["Here", "we", "show", "that", "C1704998#ent", "<e1>", "binds", "to", "model", "replication", "forks", "four-way", "junctions", "in", "vitro", "a", "C0252912#ent", "<e2>", "but", "sequence-independent", "manner", "."], "h": {"id": "C1704998", "name": "C1704998#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0252912", "name": "C0252912#ent", "pos": [16, 17]}}
{"token": ["The", "\u03b1-adrenoceptor", "antagonist", "phenoxybenzamine", ",", "the", "antimuscarinic", "agent", "atropine", ",", "the", "D-1", "dopamine", "receptor", "antagonist", "23390", ",", "the", "C0242702#ent", "<e1>", "domperidone", "and", "the", "C0242948#ent", "<e2>", "hexamethonium", "did", "not", "alter", "the", "nicotine-induced", "hypothermia", "."], "h": {"id": "C0242702", "name": "C0242702#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0242948", "name": "C0242948#ent", "pos": [23, 24]}}
{"token": ["In", "order", "to", "study", "the", "involvement", "of", "C0534519#ent", "<e1>", "in", "neuronal", "cell", "death", "we", "have", "examined", "the", "effects", "of", "viral", "caspase", "inhibitor", "C1334101#ent", "<e2>", "and", "peptide", "caspase", "inhibitors", "sympathetic", "neurons", "isolated", "from", "the", "superior", "cervical", "ganglion", "SCG", ")", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334101", "name": "C1334101#ent", "pos": [22, 23]}}
{"token": ["Instead", ",", "C1705928#ent", "<e1>", "activated", "calpain", "in", "rat", "C0669372#ent", "<e2>", ",", "probably", "through", "the", "increase", "of", "intracellular", "Ca(2+)", "from", "mitochondria", "."], "h": {"id": "C1705928", "name": "C1705928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [8, 9]}}
{"token": ["including", "tricyclic", "antidepressants", "C4048284#ent", "<e1>", ",", "phenothiazines", ",", "barbiturates", ",", "alcohol", ",", "amizepine", ",", "C0036077#ent", "<e2>", "."], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036077", "name": "C0036077#ent", "pos": [14, 15]}}
{"token": ["C1366448#ent", "<e1>", "mice", "did", "not", "correlate", "with", "cure", "rates", "the", "3", "C3540781#ent", "<e2>", "giving", "high", "cure", "rates", "."], "h": {"id": "C1366448", "name": "C1366448#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540781", "name": "C3540781#ent", "pos": [11, 12]}}
{"token": ["Strains", "that", "overexpress", "the", "C0079429#ent", "<e1>", "encoding", "the", "catalytic", "subunit", "PKA", "(", "C1418901#ent", "<e2>", ")", "or", "lack", "a", "functional", "regulatory", "subunit", "(", "rdeC", "strains", ")", "undergo", "rapid", ",", "heterochronic", "development"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418901", "name": "C1418901#ent", "pos": [12, 13]}}
{"token": ["The", "cleavage", "of", "these", "PLC-beta", "3", "C3540790#ent", "<e1>", "was", "completely", "blocked", "by", "calpain", "inhibitor", "C0108192#ent", "<e2>", ",", "indicating", "that", "the", "PLC-beta", "3", "modification", "may", "be", "a", "consequence", "of", "platelet", "activation", "to", "activation", "of", "calpain", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0108192", "name": "C0108192#ent", "pos": [14, 15]}}
{"token": ["We", "have", "discovered", "that", "several", "cryptic", "C3815527#ent", "<e1>", "and", "Delta14", "desaturase", "genes", "in", "the", "C0017428#ent", "<e2>", "of", "the", "European", "and", "Asian", "corn", "borers", "(", "Ostrinia", "nubilalis", "Ostrinia", "furnacalis", "respectively", ")", "."], "h": {"id": "C3815527", "name": "C3815527#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017428", "name": "C0017428#ent", "pos": [14, 15]}}
{"token": ["Escherichia", "coli", "strain", "5C15", "contains", "a", "mutation", "in", "the", "cca", "C0079429#ent", "<e1>", "that", "decreases", "AMP", "incorporation", "by", "C0077328#ent", "<e2>", "leaving", "CMP", "incorporation", "unaffected", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0077328", "name": "C0077328#ent", "pos": [17, 18]}}
{"token": ["Myasthenia", "gravis", "MG", ")", "is", "a", "well", "known", "side-effect", "of", "C0030817#ent", "<e1>", "used", "in", "the", "treatment", "of", "C0035436#ent", "<e2>"], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035436", "name": "C0035436#ent", "pos": [17, 18]}}
{"token": ["Antinuclear", "factors", "demonstrated", "during", "C0030817#ent", "<e1>", "treatment", "in", "patients", "with", "C0035436#ent", "<e2>", "72", ")", "and", "scleroderma", "(", "7", ")", "."], "h": {"id": "C0030817", "name": "C0030817#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035436", "name": "C0035436#ent", "pos": [10, 11]}}
{"token": ["C1567710#ent", "<e1>", "PARP-1", ";", "EC", "2.4.2.30", ",", "also", "termed", "as", "C1538577#ent", "<e2>", "is", "a", "key", "enzyme", "in", "the", "recognition", "and", "repair", "of", "damaged", "DNA", "."], "h": {"id": "C1567710", "name": "C1567710#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1538577", "name": "C1538577#ent", "pos": [10, 11]}}
{"token": ["An", "increased", "intake", "of", "long", "chain", "n-3", "fatty", "acids", "decreases", "fasting", "plasma", "triglyceride", "apoprotein", "C1424250#ent", "<e1>", "concentrations", "and", "increases", "C1422484#ent", "<e2>", "cholesterol", "concentrations", "and", "results", "in", "less", "postprandial", "lipemia", "but", "leads", "to", "an", "increase", "in", "VIIc", "."], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1422484", "name": "C1422484#ent", "pos": [19, 20]}}
{"token": ["We", "introduced", "one", "of", "these", "mutations", ",", "which", "is", "highly", "conserved", "to", "C1419856#ent", "<e1>", ",", "into", "the", "cDNA", "of", "the", "C1419862#ent", "<e2>", "encoding", "the", "a-subunit", "of", "the", "human", "skeletal", "muscle", "sodium", "channel", "hSkm1", ")", "."], "h": {"id": "C1419856", "name": "C1419856#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419862", "name": "C1419862#ent", "pos": [20, 21]}}
{"token": ["Based", "on", "gel", "shift", "assays", "nucleotide", "variations", "the", "promoters", "of", "these", "C1425774#ent", "<e1>", "or", "reduce", "binding", "of", "several", "histone", "gene", "transcription", "factors", "including", "C1334138#ent", "<e2>", ",", "HiNF-D", ",", "SP-1", "and/or", "YY1", "."], "h": {"id": "C1425774", "name": "C1425774#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334138", "name": "C1334138#ent", "pos": [23, 24]}}
{"token": ["We", "show", "here", "that", "C1421544#ent", "<e1>", "the", "NES-containing", "human", "immunodeficiency", "virus", "HIV", ")", "type", "1", "C3273437#ent", "<e2>", "relocalize", "each", "other", "to", "a", "characteristic", "dotlike", "structure", "within", "the", "nucleoli", "of", "human", "cells"], "h": {"id": "C1421544", "name": "C1421544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273437", "name": "C3273437#ent", "pos": [15, 16]}}
{"token": ["Interestingly", ",", "C1413132#ent", "<e1>", "cleaved", "at", "p3", "site", "immediately", "after", "C1539477#ent", "<e2>", "stimulation", ",", "and", "the", "cleavage", "at", "p17", "site", "became", "detectable", "later", "."], "h": {"id": "C1413132", "name": "C1413132#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [10, 11]}}
{"token": ["In", "conclusion", ",", "the", "potent", "contractile", "effects", "ET-1", "on", "C1412137#ent", "<e1>", "be", "effectively", "reversed", "but", "not", "prevented", "by", "C1335239#ent", "<e2>", "."], "h": {"id": "C1412137", "name": "C1412137#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335239", "name": "C1335239#ent", "pos": [18, 19]}}
{"token": ["Eighty-three", "samples", "from", "subjects", "with", "determined", "CYP2C19", "and", "C3887685#ent", "<e1>", "genotype", "receiving", "racemic", "C0724555#ent", "<e2>", "or", "S-citalopram", "as", "part", "of", "their", "clinical", "treatment", "collected", "from", "a", "routine", "therapeutic", "drug", "monitoring", "database", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [8, 9]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0724555", "name": "C0724555#ent", "pos": [13, 14]}}
{"token": ["The", "approval", "of", "C0247025#ent", "<e1>", "covers", "conservative", "treatment", "myocardial", "infarction", "C0002965#ent", "<e2>", "as", "well", "as", "percutaneous", "coronary", "intervention", "for", "which", "treatment", "with", "C0247025#ent", "<e1>", "is", "recommended", "in", "moderate-to-high-risk", "patients", "."], "h": {"id": "C0002965", "name": "C0002965#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0247025", "name": "C0247025#ent", "pos": [3, 4]}}
{"token": ["It", "must", "be", "distinguished", "by", "exclusion", "from", "mild", "forms", "the", "C0268579#ent", "<e1>", "may", "present", "clinically", "as", "C0268559#ent", "<e2>", "without", "ketosis", "."], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [10, 11]}, "relation": "has_manifestation", "t": {"id": "C0268559", "name": "C0268559#ent", "pos": [16, 17]}}
{"token": ["The", "C0151317#ent", "<e1>", "by", "P.", "aeruginosa", "punctuated", "by", "acute", "exacerbations", "the", "C0034049#ent", "<e2>", "which", "lead", "to", "significant", "morbidity", "and", "mortality", "."], "h": {"id": "C0151317", "name": "C0151317#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034049", "name": "C0034049#ent", "pos": [11, 12]}}
{"token": ["Although", "the", "role", "of", "abnormal", "C0033164#ent", "<e1>", "PrP", ")", "conformation", "in", "generating", "C1264609#ent", "<e2>", "transmissible", "spongiform", "encephalopathy", "has", "been", "recognized", ",", "the", "function", "of", "PrP", "in", "the", "normal", "brain", "mostly", "unknown", "."], "h": {"id": "C0033164", "name": "C0033164#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1264609", "name": "C1264609#ent", "pos": [12, 13]}}
{"token": ["Previously", "pp60v-src", ",", "cyclin", "A", "p39mos", ",", "and", "maturation-promoting", "factor", "composed", "of", "Cdc2", "and", "C1332695#ent", "<e1>", "have", "been", "shown", "to", "activate", "C0170168#ent", "<e2>", "MAPK", ")", "and", "MAPK", "kinase", "MEK", ")", "in", "cell-free", "extracts", "Xenopus", "oocytes"], "h": {"id": "C1332695", "name": "C1332695#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0170168", "name": "C0170168#ent", "pos": [21, 22]}}
{"token": ["In", "this", "report", "we", "show", "that", "C3539608#ent", "<e1>", "mRNA", "levels", "are", "induced", "by", "C0011777#ent", "<e2>", "in", "cultured", "rat", "intestinal", "epithelial", "cells", "IEC-6", ")", "."], "h": {"id": "C3539608", "name": "C3539608#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "we", "investigated", "the", "effect", "of", "treatment", "with", "C0770893#ent", "<e1>", "on", "PAI-1", "and", "C0078956#ent", "<e2>", "antigen", "levels", "in", "patients", "with", "HIV-associated", "fat", "redistribution", "."], "h": {"id": "C0770893", "name": "C0770893#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [14, 15]}}
{"token": ["C0010206#ent", "<e1>", "a", "new", "C1512076#ent", "<e2>", "was", "identified", "by", "spectroscopic", "methods", "."], "h": {"id": "C0010206", "name": "C0010206#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512076", "name": "C1512076#ent", "pos": [4, 5]}}
{"token": ["The", "sym/sub", "system", "will", "facilitate", "mechanistic", "analysis", "of", "3D(pol", ")", "and", "permit", "a", "direct", "kinetic", "and", "thermodynamic", "comparison", "of", "the", "C0035685#ent", "<e1>", "the", "other", "classes", "of", "C0035681#ent", "<e2>"], "h": {"id": "C0035685", "name": "C0035685#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [26, 27]}}
{"token": ["Variants", "within", "two", "C0017337#ent", "<e1>", ",", "the", "complement", "factor", "H", "CFH", ")", "and", "the", "poorly", "characterized", "C1824219#ent", "<e2>", "(", "ARMS2", ")", ",", "are", "widely", "recognized", "as", "ARM", "risk", "factors"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1824219", "name": "C1824219#ent", "pos": [16, 17]}}
{"token": ["In", "cultured", "cell", "experiments", "aldosterone", "directly", "increased", "the", "MCP-1", ",", "collagen", "secretion", "C0037982#ent", "<e1>", "treatment", "abolished", "aldosterone-induced", "MCP-1", "and", "C0009325#ent", "<e2>", "synthesis", "."], "h": {"id": "C0037982", "name": "C0037982#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [19, 20]}}
{"token": ["The", "association", "of", "TrkA", "receptors", "with", "C1825351#ent", "<e1>", "and", "C1709816#ent", "<e2>", "plus", "the", "inhibition", "of", "MAP", "kinase", "C1825351#ent", "<e1>", "suggests", "that", "C1825351#ent", "<e1>", "may", "provide", "a", "link", "between", "TrkA", "and", "G", "protein", "signaling", "pathways"], "h": {"id": "C1709816", "name": "C1709816#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1825351", "name": "C1825351#ent", "pos": [6, 7]}}
{"token": ["The", "Ru", "label", "specifically", "incorporated", "into", "the", "C-terminal", "C2000261#ent", "<e1>", "residue", "of", "a", "synthetic", "peptide", "23mer", ")", "containing", "the", "C1456385#ent", "<e2>", "cleavage", "sequence", "LF", "."], "h": {"id": "C2000261", "name": "C2000261#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1456385", "name": "C1456385#ent", "pos": [19, 20]}}
{"token": ["Altered", "homeostasis", "of", "CoA", "has", "been", "observed", "in", "diverse", "disease", "states", "starvation", ",", "C0011847#ent", "<e1>", ",", "alcoholism", ",", "Reye", "syndrome", "RS", ")", ",", "C0050688#ent", "<e2>", "vitamin", "B12", "deficiency", "and", "certain", "tumors", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0050688", "name": "C0050688#ent", "pos": [23, 24]}}
{"token": ["C0733397#ent", "<e1>", "significantly", "inhibited", "edema", ",", "C0020429#ent", "<e2>", ",", "and", "arthritis", "score", "TRPV1+/+", ",", "but", "not", "in", "TRPV1-/-", "mice", "."], "h": {"id": "C0733397", "name": "C0733397#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020429", "name": "C0020429#ent", "pos": [6, 7]}}
{"token": ["C0744898#ent", "<e1>", "often", "associated", "with", "increased", "response", "to", "C0003449#ent", "<e2>", "as", "capsaicin", "."], "h": {"id": "C0744898", "name": "C0744898#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003449", "name": "C0003449#ent", "pos": [8, 9]}}
{"token": ["Comparative", "genomic", "analysis", "that", "the", "gene", "arrangement", "fugu", "C2745793#ent", "<e1>", "agreed", "with", "that", "of", "human", "C1332076#ent", "<e2>", "."], "h": {"id": "C2745793", "name": "C2745793#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332076", "name": "C1332076#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "activation", "of", "C1707108#ent", "<e1>", "a", "critical", "determinant", "of", "cell", "death", "by", "C1539477#ent", "<e2>", "and", "ICE", "family", "proteases"], "h": {"id": "C1707108", "name": "C1707108#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [15, 16]}}
{"token": ["It", "is", "characterized", "by", "C0031117#ent", "<e1>", "ophthalmoplegia", ",", "deafness", ",", "leukoencephalopathy", ",", "and", "C0426576#ent", "<e2>", "to", "visceral", "neuropathy"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [13, 14]}}
{"token": ["Interestingly", ",", "we", "showed", "that", "IL-10", "modulated", "conversely", "on", "Teflon(R", ")", "and", "plastic", "the", "expression", "of", "16", "C0017337#ent", "<e1>", ",", "of", "which", "SOCS", "molecules", ",", "C0009985#ent", "<e2>", "matrix", "metalloproteinases", "complement", "receptor-1", "CD35", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0009985", "name": "C0009985#ent", "pos": [25, 26]}}
{"token": ["It", "results", "from", "mutations", "in", "the", "CPO", "C0017337#ent", "<e1>", "that", "encodes", "the", "mitochondrial", "enzyme", "C0009985#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009985", "name": "C0009985#ent", "pos": [14, 15]}}
{"token": ["This", "expression", "continues", "through", "C2983131#ent", "<e1>", ",", "with", "peak", "somatodendritic", "expression", "at", "C0079471#ent", "<e2>", "."], "h": {"id": "C2983131", "name": "C2983131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [12, 13]}}
{"token": ["In", "this", "role", "he", "provides", "the", "leadership", "and", "general", "strategy", "for", "the", "company", "'s", "drug", "discovery", "into", "C0025517#ent", "<e1>", "cardiovascular", "disorders", "inflammation", ",", "cancer", "and", "C0003205#ent", "<e2>", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0003205", "name": "C0003205#ent", "pos": [25, 26]}}
{"token": ["Muscle", "insulin", "binding", "and", "peptide", "contents", "of", "insulin", "receptor", "IRS-1", ",", "p85", "subunit", "C2713509#ent", "<e1>", ",", "Akt/PKB", ",", "and", "atypical", "PKC", "isoform", "C3889400#ent", "<e2>", "were", "not", "different", "between", "EtOH-exposed", "rats", "and", "controls", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3889400", "name": "C3889400#ent", "pos": [22, 23]}}
{"token": ["Protofibrillar", "C1415831#ent", "<e1>", ",", "like", "protofibrillar", "C1420276#ent", "<e2>", ",", "which", "is", "implicated", "in", "Parkinson's", "disease", "pathogenesis", ",", "permeabilizes", "synthetic", "vesicles", "a", "pore-like", "mechanism", "."], "h": {"id": "C1415831", "name": "C1415831#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [6, 7]}}
{"token": ["RPR-mediated", "apoptosis", "was", "blocked", "by", "N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone", "(", "C0383779#ent", "<e1>", ")", ",", "which", "suggests", "that", "an", "C1705786#ent", "<e2>", "required", "for", "RPR", "function", "."], "h": {"id": "C0383779", "name": "C0383779#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705786", "name": "C1705786#ent", "pos": [15, 16]}}
{"token": ["C1421249#ent", "<e1>", "inhibition", "blocked", "wild", "type", "C3889257#ent", "<e2>", "down-regulation", "by", "50", "%", ",", "and", "the", "genistein-resistant", "wild", "type", "C3889257#ent", "<e2>", "down-regulation", "was", "completely", "pertussis", "toxin-sensitive", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889257", "name": "C3889257#ent", "pos": [6, 7]}}
{"token": ["Analysis", "of", "the", "-14", "gene", "promoter", "that", "it", "is", "GC", "rich", "and", "associated", "with", "constitutively", "expressed", "C0011519#ent", "<e1>", "hypersensitive", "site", "unlike", "the", "C0544482#ent", "<e2>", "it", "does", "not", "contain", "a", "TATA", "or", "CCAAT", "box", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0544482", "name": "C0544482#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "report", "that", "mossy", "fiber", "LTP", "was", "reduced", "by", "perfusion", "of", "postsynaptic", "neurons", "C0030956#ent", "<e1>", "and", "antibodies", "that", "interfere", "with", "binding", "of", "C0812262#ent", "<e2>", "EphRs", ")", "to", "the", "PDZ", "protein", "GRIP", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812262", "name": "C0812262#ent", "pos": [23, 24]}}
{"token": ["In", "differentiated", ",", "but", "not", "undifferentiated", "cells", "C1704467#ent", "<e1>", "and", "Akt", "also", "inhibited", "apoptosis", "downstream", "of", "C1415491#ent", "<e2>", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415491", "name": "C1415491#ent", "pos": [16, 17]}}
{"token": ["This", "C0039082#ent", "<e1>", "is", "now", "called", "C1519711#ent", "<e2>", "ALPS", "I", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1519711", "name": "C1519711#ent", "pos": [6, 7]}}
{"token": ["Renal-transplant", "patients", "who", "are", "immunosuppressed", "with", "C0010592#ent", "<e1>", "CyA", ")", "are", "often", "treated", "with", "C0358591#ent", "<e2>", "prevent", "ulcer", "disease"], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0358591", "name": "C0358591#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "we", "found", "that", "C1420225#ent", "<e1>", "secretion", "could", "be", "down-regulated", "by", "C0011777#ent", "<e2>", "in", "HT", "1080", "cells", "but", "not", "in", "COLO", "205", "cells", "."], "h": {"id": "C1420225", "name": "C1420225#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [13, 14]}}
{"token": ["The", "mechanisms", "underlying", "these", "clocks", "are", "remarkably", "conserved", "across", "evolution", "and", "typically", "consist", "of", "auto-regulatory", "loops", "in", "which", "specific", "proteins", "(", "C1413503#ent", "<e1>", "rhythmically", "repress", "expression", "of", "their", "own", "C0017337#ent", "<e2>", "."], "h": {"id": "C1413503", "name": "C1413503#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [29, 30]}}
{"token": ["Of", "the", "C1705981#ent", "<e1>", "characterized", ",", "only", "C3813712#ent", "<e2>", ",", "M", "and", "O", "were", "closely", "linked", "."], "h": {"id": "C1705981", "name": "C1705981#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3813712", "name": "C3813712#ent", "pos": [7, 8]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "compare", "the", "inhibitory", "effects", "of", "fluvoxamine", ",", "an", "inhibitor", "of", "C0960580#ent", "<e1>", ",", "on", "the", "metabolism", "of", "C0050940#ent", "<e2>", "between", "CYP2C19", "genotypes"], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [17, 18]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0050940", "name": "C0050940#ent", "pos": [24, 25]}}
{"token": ["Section", "of", "the", "C1842743#ent", "<e1>", "and", "S1", "dorsal", "roots", "did", "not", "affect", "the", "C3889697#ent", "<e2>", "seen", "with", "5-Hz", "ventral", "root", "stimulation", "."], "h": {"id": "C1842743", "name": "C1842743#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889697", "name": "C3889697#ent", "pos": [13, 14]}}
{"token": ["Duplex", "scanning", "has", "the", "potential", "for", "improved", "detection", "of", "early", "C0007273#ent", "<e1>", "study", "of", "the", "natural", "history", "C0004153#ent", "<e2>", "."], "h": {"id": "C0007273", "name": "C0007273#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [17, 18]}}
{"token": ["There", "is", "a", "significant", "correlation", "between", "the", "regional", "distribution", "of", "PH4", "and", "C0001962#ent", "<e1>", "but", "not", "between", "PH4", "and", "C1420870#ent", "<e2>", "between", "either", "C0001962#ent", "<e1>", "or", "C1420870#ent", "<e2>", "QDPR", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [19, 20]}}
{"token": ["Despite", "improved", "supportive", "care", "and", "the", "introduction", "of", "less", "toxic", "lipid-formulations", "of", "C0051761#ent", "<e1>", "other", "new", "antifungal", "agents", "mortality", "from", "invasive", "fungal", "infection", "C1334085#ent", "<e2>", ")", "in", "hematology", "patients", "remains", "high", "."], "h": {"id": "C0051761", "name": "C0051761#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334085", "name": "C1334085#ent", "pos": [23, 24]}}
{"token": ["Although", "acute", "myocardial", "infarction", "C0027051#ent", "<e1>", ")", "is", "the", "most", "serious", "C1956346#ent", "<e2>", "the", "background", "of", "its", "onset", "and", "the", "mortality", "are", "not", "fully", "understood", ",", "especially", "in", "Japan", "."], "h": {"id": "C0027051", "name": "C0027051#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [11, 12]}}
{"token": ["The", "renal", "clearance", "the", "main", "oxidative", "metabolites", "antipyrine", "(", "4-hydroxyantipyrine", ",", "3-hydroxymethylantipyrine", "and", "C0003420#ent", "<e1>", ")", "were", "increased", "after", "C0038742#ent", "<e2>", "(", "p", "less", "than", "0.02", ")", "."], "h": {"id": "C0003420", "name": "C0003420#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038742", "name": "C0038742#ent", "pos": [19, 20]}}
{"token": ["In", "conclusion", ",", "C1419131#ent", "<e1>", "may", "play", "a", "role", "in", "inflammatory", "circuits", "of", "C0003873#ent", "<e2>", ",", "and", "its", "relevance", "as", "a", "marker", "of", "disease", "activity", "further", "study", "."], "h": {"id": "C1419131", "name": "C1419131#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}}
{"token": ["Compared", "with", "the", "normal", "subjects", "the", "C0231218#ent", "<e1>", "patients", "had", "large", "amounts", "of", "mannosidase", ",", "C0016787#ent", "<e2>", ",", "hexosaminidase", ",", "and", "sialidase", "activity"], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016787", "name": "C0016787#ent", "pos": [15, 16]}}
{"token": ["A", "49", "year", "old", "caucasian", "female", "with", "C0677607#ent", "<e1>", "developed", "during", "two", "years", "a", "neurological", "disorder", "C0494475#ent", "<e2>", "and", "myoclonic", "seizures", "confusional", "states"], "h": {"id": "C0677607", "name": "C0677607#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0494475", "name": "C0494475#ent", "pos": [16, 17]}}
{"token": ["The", "addition", "of", "C1562036#ent", "<e1>", "okadaic", "acid", "calyculin", "A", "completely", "abolished", "the", "effects", "of", "insulin", "on", "both", "C3541394#ent", "<e2>", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [17, 18]}}
{"token": ["For", "curative", "liver", "protective", "agents", "inhibitors", "of", "RNA", "and", "protein", "synthesis", "C1562036#ent", "<e1>", "inhibitors", "of", "sulfhydryl", "(", "-SH", ")", "containing", "C3541394#ent", "<e2>", "are", "proposed", "and", "substantiated", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [20, 21]}}
{"token": ["By", "using", "the", "Cre-loxP", "recombination", "system", "we", "show", "that", "the", "mammary", "gland", "C1423996#ent", "<e1>", "mice", ",", "in", "which", "secretory", "epithelial", "cells", "the", "C0022959#ent", "<e2>", "pregnancy", ",", "contains", "labeled", "adipocytes", "during", "involution", "."], "h": {"id": "C1423996", "name": "C1423996#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022959", "name": "C0022959#ent", "pos": [22, 23]}}
{"token": ["Based", "on", "these", "results", ",", "we", "conclude", "that", "the", "ERK5", "signaling", "pathway", "promotes", "cell", "survival", "downregulating", "C1539478#ent", "<e1>", "expression", "via", "a", "mechanism", "that", "implicates", "PKB-dependent", "inhibition", "of", "C1333573#ent", "<e2>", "downstream", "of", "phosphoinositide", "3", "kinase"], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333573", "name": "C1333573#ent", "pos": [27, 28]}}
{"token": ["Second", ",", "nisoldipine", "was", "administered", "into", "the", "canine", "coronary", "artery", "the", "ischemic", "myocardium", "with", "and", "without", "administration", "of", "either", "C2930448#ent", "<e1>", "NaHCO3", ")", ",", "sodium", "hydroxide", "NaOH", ")", ",", "or", "C0002502#ent", "<e2>", "."], "h": {"id": "C2930448", "name": "C2930448#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0002502", "name": "C0002502#ent", "pos": [30, 31]}}
{"token": ["The", "inserted", "DNA", "contained", "a", "C1421976#ent", "<e1>", "to", "create", "an", "in-frame", "fusion", "with", "the", "int-2", "C0079941#ent", "<e2>"], "h": {"id": "C1421976", "name": "C1421976#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}}
{"token": ["However", ",", "it", "is", "not", "completely", "clear", "that", "C3273648#ent", "<e1>", "and", "HNF-1beta", "play", "a", "role", "in", "regulation", "of", "C1420044#ent", "<e2>", "."], "h": {"id": "C3273648", "name": "C3273648#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420044", "name": "C1420044#ent", "pos": [18, 19]}}
{"token": ["Decreases", "in", "bone", "resorption", "markers", "including", "urinary", "total", "deoxypyridinoline", "NTX", "were", "significantly", "greater", "in", "the", "C0246719#ent", "<e1>", "group", "than", "in", "the", "C0037507#ent", "<e2>", "group", "throughout", "the", "treatment", "period", "."], "h": {"id": "C0246719", "name": "C0246719#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0037507", "name": "C0037507#ent", "pos": [21, 22]}}
{"token": ["Treatment", "of", "C0020514#ent", "<e1>", "with", "oral", "C0006230#ent", "<e2>", "has", "been", "associated", "with", "high", "incidence", "of", "side", "effects"], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0006230", "name": "C0006230#ent", "pos": [6, 7]}}
{"token": ["Two", "children", "with", "C0401151#ent", "<e1>", "the", "dominating", "symptom", "of", "C3539598#ent", "<e2>", "are", "presented", "."], "h": {"id": "C0401151", "name": "C0401151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539598", "name": "C3539598#ent", "pos": [9, 10]}}
{"token": ["The", "activity", "of", "both", "C0597094#ent", "<e1>", "determined", "in", "a", "new", "assay", "allows", "to", "discriminate", "C1336670#ent", "<e2>", "DNase", "I", "the", "same", "extract", "."], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336670", "name": "C1336670#ent", "pos": [14, 15]}}
{"token": ["Sections", "of", "six", "brain", "regions", "each", "animal", "were", "analyzed", "by", "radioimmunoassay", "for", "C1333714#ent", "<e1>", ",", "cholecystokinin", ",", "neurotensin", "and", "C0143060#ent", "<e2>"], "h": {"id": "C1333714", "name": "C1333714#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0143060", "name": "C0143060#ent", "pos": [19, 20]}}
{"token": ["This", "report", "details", "the", "management", "of", "status", "epilepticus", "high-dose", "lorazepam", "in", "a", "14-year-old", "patient", "who", "was", "receiving", "oral", "clonazepam", ",", "C0015043#ent", "<e1>", ",", "and", "phenobarbital", "for", "an", "C0014544#ent", "<e2>"], "h": {"id": "C0015043", "name": "C0015043#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [27, 28]}}
{"token": ["Dent's", "disease", "C0268164#ent", "<e1>", "inherited", "causes", "of", "C1833683#ent", "<e2>", "are", "both", "associated", "with", "nephrocalcinosis", "and", "urolithiasis", "in", "early", "childhood", "renal", "failure", "can", "occur", "at", "any", "age", "but", "is", "seen", "more", "often", "in", "adulthood", "."], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C1833683", "name": "C1833683#ent", "pos": [7, 8]}}
{"token": ["It", "has", "been", "suggested", "that", "C1423996#ent", "<e1>", "WAP", ")", "may", "function", "as", "a", "C0033607#ent", "<e2>"], "h": {"id": "C1423996", "name": "C1423996#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [13, 14]}}
{"token": ["To", "define", "the", "basis", "of", "inhibition", "of", "CRP-Fn", "interaction", "by", "Ca2", "+", "at", "pH", "7.0", ",", "we", "hypothesized", "that", "Fn-binding", "site", "on", "C1826658#ent", "<e1>", "consisted", "of", "C3539947#ent", "<e2>", "Ca2", "+", "."], "h": {"id": "C1826658", "name": "C1826658#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [26, 27]}}
{"token": ["Recent", "studies", "have", "shown", "that", "HK", "C0026794#ent", "<e1>", "with", "a", "C1416810#ent", "<e2>", "a", "role", "in", "mitochondrial", "integrity", "suggesting", "that", "HK-I-deficient", "erythroid", "cells", "might", "be", "eliminated", "by", "apoptosis", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416810", "name": "C1416810#ent", "pos": [10, 11]}}
{"token": ["We", "investigated", "the", "function", "of", "estrogen", "receptor-alpha", "C0151744#ent", "<e1>", "reperfusion", "injury", "male", "estrogen", "receptor-alpha", "knockout", "(", "ERKO", ")", "and", "C2987364#ent", "<e2>"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [19, 20]}}
{"token": ["C0007684#ent", "<e1>", "free-living", "amebas", "should", "be", "considered", "in", "C0025309#ent", "<e2>", "with", "bacterial-free", "cerebro-spinal", "fluid", "."], "h": {"id": "C0007684", "name": "C0007684#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0025309", "name": "C0025309#ent", "pos": [8, 9]}}
{"token": ["We", "characterized", "one", "of", "the", "H1", "genes", "was", "linked", "to", "an", "H2a", ",", "an", "H2b", ",", "an", "C1424771#ent", "<e1>", ",", "and", "an", "C1425774#ent", "<e2>"], "h": {"id": "C1424771", "name": "C1424771#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1425774", "name": "C1425774#ent", "pos": [22, 23]}}
{"token": ["In", "conclusion", ",", "we", "have", "demonstrated", "that", "isoflurane", "and", "C0074414#ent", "<e1>", "produce", "bronchodilation", "in", "patients", "with", "C3714496#ent", "<e2>", "."], "h": {"id": "C0074414", "name": "C0074414#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3714496", "name": "C3714496#ent", "pos": [16, 17]}}
{"token": ["Secretion", "of", "SP-B", "and", "C1442758#ent", "<e1>", "was", "increased", "sevenfold", "by", "C0039542#ent", "<e2>", "and", "threefold", "by", "ATP", ",", "effects", "similar", "those", "in", "rat", "type", "II", "cells"], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039542", "name": "C0039542#ent", "pos": [10, 11]}}
{"token": ["Secretion", "of", "phosphatidylcholine", ",", "surfactant", "protein", "and", "C1442758#ent", "<e1>", "was", "stimulated", "by", "C0039542#ent", "<e2>", ",", "5'-N-ethylcarboxyamidoadenosine", "(", "NECA", ")", ",", "ATP", ",", "UTP", ",", "TPA", ",", "and", "ionomycin", "."], "h": {"id": "C1442758", "name": "C1442758#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039542", "name": "C0039542#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "C1336938#ent", "<e1>", "is", "also", "able", "to", "potentiate", "5-HT", "secretion", "responses", "to", "C1097538#ent", "<e2>", "confirming", "that", "GPVI", "is", "able", "to", "support", "synergy", "with", "C1336938#ent", "<e1>", "."], "h": {"id": "C1097538", "name": "C1097538#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [3, 4]}}
{"token": ["Accordingly", ",", "several", "C1417679#ent", "<e1>", "involved", "in", "cell", "proliferation", "signaling", ",", "such", "as", "Lck", ",", "Kcnn4", ",", "Cdc37", ",", "cyclin", "D3", "C1412719#ent", "<e2>", ",", "and", "Ms4a11", ",", "have", "been", "identified", "as", "OCA-B-dependent", "C1417679#ent", "<e1>", "."], "h": {"id": "C1412719", "name": "C1412719#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}}
{"token": ["These", "findings", "indicate", "that", "C3714497#ent", "<e1>", "a", "decrease", "in", "diffusing", "capacity", "not", "rare", "in", "C0007222#ent", "<e2>", "patients", ",", "even", "if", "they", "had", "neither", "a", "smoking", "history", "abnormal", "findings", "in", "their", "chest", "x-ray", "films"], "h": {"id": "C3714497", "name": "C3714497#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [14, 15]}}
{"token": ["Characteristic", "white", "matter", "lesions", "were", "also", "demonstrated", "in", "adrenoleukodystrophy", ",", "C0162534#ent", "<e1>", "progressive", "multifocal", "leukoencephalopathy", "disseminated", "necrotizing", "leukoencephalopathy", "and", "an", "undiagnosed", "C0270612#ent", "<e2>", "associated", "with", "malignancy", "."], "h": {"id": "C0162534", "name": "C0162534#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0270612", "name": "C0270612#ent", "pos": [21, 22]}}
{"token": ["We", "have", "used", "here", "polyclonal", "antisera", "and", "monoclonal", "antibodies", "indirect", "immunofluorescence", "microscopy", "study", "the", "subcellular", "location", "C2983131#ent", "<e1>", "and", "the", "C0069879#ent", "<e2>", ",", "which", "is", "a", "subplasmalemmal", "polypeptide", "showing", "immunologic", "cross-reactivity", "with", "erythrocyte", "alpha-spectrin", "."], "h": {"id": "C2983131", "name": "C2983131#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0069879", "name": "C0069879#ent", "pos": [20, 21]}}
{"token": ["We", "found", "that", "80", "%", "of", "patients", "with", "rheumatic", "fever", "C1263744#ent", "<e1>", "an", "elevation", "of", "the", "group", "A", "C0032594#ent", "<e2>", "titer", "."], "h": {"id": "C1263744", "name": "C1263744#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [18, 19]}}
{"token": ["Nevertheless", ",", "Xa4", "T", "still", "acted", "as", "a", "recessive", "C0597336#ent", "<e1>", "with", "a", "significant", "residual", "effect", "against", "C1332701#ent", "<e2>", "."], "h": {"id": "C0597336", "name": "C0597336#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332701", "name": "C1332701#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "the", "expression", "of", "MHC", "class", "II", "DQ", "beta1", "(", "C1415572#ent", "<e1>", ")", "was", "significantly", "reduced", "in", "C0003873#ent", "<e2>", "patients", "compared", "to", "healthy", "controls"], "h": {"id": "C1415572", "name": "C1415572#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["A", "gradient", ",", "reversed-phase", "liquid", "chromatographic", "RP-LC", ")", "method", "was", "developed", "for", "the", "quantitative", "determination", "of", "C0772420#ent", "<e1>", "used", "to", "treat", "relieves", "C0149931#ent", "<e2>", "symptoms", "."], "h": {"id": "C0772420", "name": "C0772420#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [22, 23]}}
{"token": ["The", "consequence", "of", "t(5;7)(q33;q11.2", ")", "is", "an", "C3274773#ent", "<e1>", "encodes", "amino", "acids", "1", "950", "of", "C1415546#ent", "<e2>", "joined", "in-frame", "to", "the", "transmembrane", "and", "tyrosine", "kinase", "domains", "the", "PDGFbetaR.", "The", "reciprocal", "PDGFbetaR/HIP1", "transcript", "is", "not", "expressed", "."], "h": {"id": "C3274773", "name": "C3274773#ent", "pos": [7, 8]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1415546", "name": "C1415546#ent", "pos": [15, 16]}}
{"token": ["The", "serum", "levels", "of", "the", "BB", "C1412365#ent", "<e1>", "of", "creatine", "kinase", "CK-BB", ")", "and", "C1880904#ent", "<e2>", "NSE", ")", "were", "measured", "before", "therapy", "in", "35", "patients", "with", "neuroblastoma", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [14, 15]}}
{"token": ["A", "21-year-old", "woman", "developed", "epilepsy", ",", "disturbance", "of", "mental", "state", "and", "C0575059#ent", "<e1>", "the", "convalescent", "period", "after", "C0546994#ent", "<e2>"], "h": {"id": "C0575059", "name": "C0575059#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0546994", "name": "C0546994#ent", "pos": [17, 18]}}
{"token": ["In", "the", "yeast", "Saccharomyces", "cerevisiae", "the", "activation", "of", "adenylate", "cyclase", "the", "products", "of", "the", "RAS", "C1417679#ent", "<e1>", "and", "of", "C1705121#ent", "<e2>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705121", "name": "C1705121#ent", "pos": [19, 20]}}
{"token": ["C1417679#ent", "<e1>", "involved", "in", "Ras", "and", "ubiquitin", "pathways", "C1705121#ent", "<e2>", ",", "RAC3", ",", "and", "UBE2D3", ",", "were", "downregulated", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705121", "name": "C1705121#ent", "pos": [8, 9]}}
{"token": ["The", "aim", "of", "the", "present", "investigation", "was", "to", "study", "the", "effect", "of", "acute", "swimming", "training", "an", "anaerobic", "component", "on", "matrix", "metallopeptidase", "C0919336#ent", "<e1>", ")", "activity", "and", "C3815884#ent", "<e2>", "expression", "in", "the", "rat", "myocardium", "."], "h": {"id": "C0919336", "name": "C0919336#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3815884", "name": "C3815884#ent", "pos": [26, 27]}}
{"token": ["C0025654#ent", "<e1>", "antagonized", "the", "effects", "of", "C0357797#ent", "<e2>", "(", "7.4", "less", "than", "pKB", "less", "than", "8.8", ")", "."], "h": {"id": "C0025654", "name": "C0025654#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0357797", "name": "C0357797#ent", "pos": [6, 7]}}
{"token": ["C0017428#ent", "<e1>", "in", "which", "the", "MHV", "5'UTR", "C1420571#ent", "<e2>", ",", "SL2", ",", "and", "SL4", "were", "individually", "replaced", "by", "their", "SCoV", "counterparts", "were", "viable", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420571", "name": "C1420571#ent", "pos": [7, 8]}}
{"token": ["Correlations", "between", "C3887648#ent", "<e1>", ",", "soluble", "sugars", "and", "C0054259#ent", "<e2>", "concentration", "have", "been", "recently", "reported", "for", "potato", "plants", "tyrosine", "decarboxylase", "the", "enzyme", "mediating", "the", "first", "step", "of", "catecholamine", "synthesis", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0054259", "name": "C0054259#ent", "pos": [8, 9]}}
{"token": ["WRN", "gene", "one", "of", "the", "RecQ", "helicase", "family", "proteins", "C0388246#ent", "<e1>", ",", "which", "has", "ATPase", ",", "C0920283#ent", "<e2>", ",", "exonuclease", "and", "single", "stranded", "DNA", "annealing", "activities"], "h": {"id": "C0388246", "name": "C0388246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0920283", "name": "C0920283#ent", "pos": [16, 17]}}
{"token": ["While", "the", "oxygen-containing", "coumaran", "and", "benzofuran", "both", "increased", "the", "NADH", ":", "C1136197#ent", "<e1>", "in", "hepatic", "cytosol", "the", "nitrogen-containing", "indole", "and", "C0063491#ent", "<e2>", "did", "not", "."], "h": {"id": "C1136197", "name": "C1136197#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0063491", "name": "C0063491#ent", "pos": [20, 21]}}
{"token": ["Two", "dimensional", "flow", "cytometric", "analysis", "indicated", "that", "the", "vast", "majority", "of", "the", "E-positive", "fraction", "were", "C3274824#ent", "<e1>", "beta", "TLC", "expressing", "CD3", "and", "C1706438#ent", "<e2>"], "h": {"id": "C3274824", "name": "C3274824#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [22, 23]}}
{"token": ["The", "major", "amyloid", "protein", "the", "C0271408#ent", "<e1>", "in", "C0740340#ent", "<e2>", "but", "not", "control", "C0271408#ent", "<e1>", ")", "was", "found", "to", "be", "prealbumin", "."], "h": {"id": "C0740340", "name": "C0740340#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0271408", "name": "C0271408#ent", "pos": [5, 6]}}
{"token": ["Recent", "studies", "have", "shown", "that", "inhibitors", "of", "C0019643#ent", "<e1>", "relieve", "transcriptional", "repression", "by", "the", "products", "of", "certain", "C0037207#ent", "<e2>", "."], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037207", "name": "C0037207#ent", "pos": [17, 18]}}
{"token": ["C3537282#ent", "<e1>", "PV-1", ")", "is", "an", "C0021699#ent", "<e2>", "associated", "with", "endothelial", "cell", "caveolae", "fenestrae", "."], "h": {"id": "C3537282", "name": "C3537282#ent", "pos": [0, 1]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}}
{"token": ["Previously", ",", "we", "reported", "on", "the", "approximately", "60-kDa", "C0119452#ent", "<e1>", "(", "Lgt1", ")", "from", "Legionella", "pneumophila", "which", "modified", "C1870461#ent", "<e2>"], "h": {"id": "C0119452", "name": "C0119452#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1870461", "name": "C1870461#ent", "pos": [18, 19]}}
{"token": ["The", "decrease", "in", "C1366439#ent", "<e1>", "was", "greater", "with", "bisoprolol", "than", "with", "C0287041#ent", "<e2>", "."], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "two", "different", "response", "patterns", "were", "obtained", "from", "C3889643#ent", "<e1>", "and", "CN", "following", "chronic", "C0700545#ent", "<e2>", "administration", "."], "h": {"id": "C3889643", "name": "C3889643#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0700545", "name": "C0700545#ent", "pos": [15, 16]}}
{"token": ["This", "study", "determined", "the", "efficacy", "of", "C0937846#ent", "<e1>", "for", "reducing", "the", "risk", "of", "gastric", "and/or", "C0013295#ent", "<e2>", "dyspeptic", "symptoms", "patients", "receiving", "continuous", ",", "low-dose", "aspirin", "therapy"], "h": {"id": "C0937846", "name": "C0937846#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [15, 16]}}
{"token": ["C3541431#ent", "<e1>", ",", "or", "a", "closely", "related", "C0014442#ent", "<e2>", ",", "would", "thus", "seem", "to", "play", "a", "role", "in", "the", "control", "of", "autophagy", "as", "well", "as", "in", "the", "control", "of", "cytoskeletal", "organization"], "h": {"id": "C3541431", "name": "C3541431#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["Three", "of", "the", "enzymatic", "activities", "of", "de", "novo", "purine", "synthesis", "C1414989#ent", "<e1>", "GARS", ")", ",", "aminoimidazole", "ribonucleotide", "synthetase", "AIRS", ")", "and", "C1530787#ent", "<e2>", "GART", ")", ",", "can", "be", "catalyzed", "by", "a", "single", "110-kDa", "protein", "in", "mouse", "cells"], "h": {"id": "C1414989", "name": "C1414989#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1530787", "name": "C1530787#ent", "pos": [21, 22]}}
{"token": ["A", "single", "mouse", "genomic", "locus", "proteins", "catalyzing", "three", "steps", "of", "purine", "synthesis", "C1414989#ent", "<e1>", "GARS", ")", ",", "aminoimidazole", "ribonucleotide", "synthetase", "AIRS", ")", ",", "and", "C1530787#ent", "<e2>", "GART", ")", "."], "h": {"id": "C1414989", "name": "C1414989#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1530787", "name": "C1530787#ent", "pos": [24, 25]}}
{"token": ["One", "gene", "encodes", "enzymes", "in", "the", "de", "novo", "purine", "nucleotide", "biosynthesis", "pathway", "C1414989#ent", "<e1>", "GARS", ")", ",", "aminoimidazole", "ribonucleotide", "synthetase", "AIRS", ")", ",", "and", "glycinamide", "ribonucleotide", "transformylase", "C1530787#ent", "<e2>", ")", "]", "."], "h": {"id": "C1414989", "name": "C1414989#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1530787", "name": "C1530787#ent", "pos": [27, 28]}}
{"token": ["Although", "AA", "stimulates", "C1333673#ent", "<e1>", "secretion", ",", "its", "C0023835#ent", "<e2>", "and", "cyclooxygenase", "metabolites", "probably", "do", "not", "mediate", "sGnRH", "action", "on", "somatotropes", "."], "h": {"id": "C1333673", "name": "C1333673#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023835", "name": "C0023835#ent", "pos": [8, 9]}}
{"token": ["Third", ",", "Lefty", "restricts", "the", "range", "of", "Squint", "activity", "in", "C0038379#ent", "<e1>", "mutant", "embryos", ",", "in", "which", "the", "endogenous", "C0079429#ent", "<e2>", "is", "not", "subject", "to", "autoregulation", "."], "h": {"id": "C0038379", "name": "C0038379#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [19, 20]}}
{"token": ["Propranolol", ",", "prazosin", ",", "C0729169#ent", "<e1>", ",", "methysergide", ",", "sulpiride", "and", "C0031935#ent", "<e2>", "were", "unable", "to", "block", "its", "activity", "."], "h": {"id": "C0729169", "name": "C0729169#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031935", "name": "C0031935#ent", "pos": [11, 12]}}
{"token": ["Increased", "activity", "of", "HAT", "was", "suppressed", "by", "C0038317#ent", "<e1>", "treatment", ",", "but", "the", "marked", "diminution", "of", "C0768528#ent", "<e2>", "activity", "and", "increased", "activity", "of", "nuclear", "factor-kappaB", "not", "reversed", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0768528", "name": "C0768528#ent", "pos": [16, 17]}}
{"token": ["\"", "Cone", "dystrophy", "supernormal", "rod", "electroretinogram", "C1705964#ent", "<e1>", ")", "\"", "is", "an", "autosomal", "recessive", "disorder", "causes", "lifelong", "visual", "loss", "with", "a", "supernormal", "C1705964#ent", "<e1>", "response", "to", "a", "C3539536#ent", "<e1>"], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3539536", "name": "C3539536#ent", "pos": [27, 28]}}
{"token": ["The", "inhibition", "pattern", "suggests", "a", "metallo-endopeptidase", "thermolysin-like", "character", "with", "the", "involvement", "of", "C0599532#ent", "<e1>", "group(s", ")", ",", "clearly", "distinct", "from", "neutral", "endopeptidase", "NEP", ";", "C3887624#ent", "<e2>", "."], "h": {"id": "C0599532", "name": "C0599532#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3887624", "name": "C3887624#ent", "pos": [24, 25]}}
{"token": ["Transient", "co-transfection", "of", "bovine", "CRLR", "cDNA", "with", "human", "receptor", "modifying", "protein", "1", "hRAMP1", ")", "cDNA", "in", "HEK-293", "cells", "resulted", "in", "the", "expression", "of", "a", "C1424497#ent", "<e1>", "that", "displayed", "C1721278#ent", "<e2>", "calcitonin", "gene-related", "peptide"], "h": {"id": "C1424497", "name": "C1424497#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1721278", "name": "C1721278#ent", "pos": [28, 29]}}
{"token": ["Blood", "pressures", "25", "stable", "end-stage", "renal", "disease", "patients", "with", "C0581384#ent", "<e1>", "mean", "hemoglobin", "g/dL", ")", "who", "had", "received", "2", "units", "of", "C2316467#ent", "<e2>", "hemodialysis", "were", "studied", "."], "h": {"id": "C0581384", "name": "C0581384#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2316467", "name": "C2316467#ent", "pos": [21, 22]}}
{"token": ["A", "C3889703#ent", "<e1>", "reporter", "gene", "knocked", "into", "the", "CARMA1", "locus", "confirmed", "C1416925#ent", "<e2>", "CARMA1", "."], "h": {"id": "C3889703", "name": "C3889703#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416925", "name": "C1416925#ent", "pos": [11, 12]}}
{"token": ["Cervical", "spinal", "cord", "stimulation", "SCS", ")", "was", "used", "to", "increase", "cerebral", "blood", "flow", "C1428360#ent", "<e1>", ")", "in", "10", "patients", "with", "C1290398#ent", "<e2>", "Hunt", "and", "Hess", "grade", "3", "4", "and", "with", "Fisher", "group", "3", "subarachnoid", "hemorrhage", "SAH", ")", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1290398", "name": "C1290398#ent", "pos": [20, 21]}}
{"token": ["Polycystin-1", "(", "C3849253#ent", "<e1>", ")", "is", "a", "large", "C0021699#ent", "<e2>", "in", "renal", "differentiation", "defective", "in", "most", "cases", "of", "autosomal", "dominant", "polycystic", "kidney", "disease", "ADPKD", ")", ",", "a", "common", "cause", "of", "renal", "failure", "adults", "."], "h": {"id": "C3849253", "name": "C3849253#ent", "pos": [2, 3]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}}
{"token": ["However", ",", "if", "this", "C2239482#ent", "<e1>", "site", "is", "first", "methylated", "by", "Dam", ",", "binding", "of", "C1416912#ent", "<e2>", "and", "Papl", "is", "inhibited", "."], "h": {"id": "C2239482", "name": "C2239482#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416912", "name": "C1416912#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "a", "10-year-old", "girl", "with", "C0392514#ent", "<e1>", "is", "associated", "with", "normal", "concentration", "of", "S-ferritin", ",", "C0033141#ent", "<e2>", "diabetes", "mellitus"], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033141", "name": "C0033141#ent", "pos": [16, 17]}}
{"token": ["Peribiliary", "cysts", "been", "reported", "in", "various", "liver", "diseases", "including", "portal", "hypertension", "portal", "thrombosis", "C0023890#ent", "<e1>", ",", "hepatocellular", "carcinoma", "and", "adult", "C3149841#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [20, 21]}}
{"token": ["A", "clinical", "C1875400#ent", "<e1>", "of", "Enterococcus", "faecium", "contains", "a", "chromosomally", "encoded", "C1413514#ent", "<e2>", "Tn1546::IS1251", ",", "transferred", "vancomycin", "resistance", "to", "the", "plasmid-free", "strain", "Enterococcus", "faecalis", "JH2", "2", "during", "filter", "matings"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413514", "name": "C1413514#ent", "pos": [11, 12]}}
{"token": ["The", "171-bp", "fragment", "obtained", "encodes", "an", "C1412821#ent", "<e1>", "57", "amino", "acids", "65", "%", "identity", "to", "the", "rat", "C1511396#ent", "<e2>"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1511396", "name": "C1511396#ent", "pos": [17, 18]}}
{"token": ["These", "reagents", "have", "allowed", "the", "isolation", "and", "characterization", "of", "the", "cDNAs", "of", "the", "various", "preformed", "C0127400#ent", "<e1>", "the", "secretory", "granule", "proteoglycan", "peptide", "core", ",", "C0036734#ent", "<e2>", "carboxypeptidase", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [24, 25]}}
{"token": ["Sixty", "patients", "had", "C0008325#ent", "<e1>", "64", "had", "chronic", "cholecystitis", "and", "87", "had", "no", "demonstrable", "C2609268#ent", "<e2>"], "h": {"id": "C0008325", "name": "C0008325#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C2609268", "name": "C2609268#ent", "pos": [14, 15]}}
{"token": ["C0008035#ent", "<e1>", "complications", "include", "diskitis", "and", "vertebral", "osteomyelitis", "C0270629#ent", "<e2>", "necrotizing", "fasciitis", "costochondritis", ",", "and", "septic", "arthritis"], "h": {"id": "C0008035", "name": "C0008035#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270629", "name": "C0270629#ent", "pos": [8, 9]}}
{"token": ["Two", "percent", "of", "oil", "from", "C3541860#ent", "<e1>", "added", "to", "a", "yeast", "isolation", "medium", "as", "a", "sole", "C0524928#ent", "<e2>", "source", "."], "h": {"id": "C3541860", "name": "C3541860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "resistin", "(", "C0014758#ent", "<e1>", ")", "mRNA", "was", "increased", "in", "the", "C0001614#ent", "<e2>", "only", "at", "21", "days", "after", "hypoxia/ischaemia", "."], "h": {"id": "C0014758", "name": "C0014758#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [13, 14]}}
{"token": ["These", "results", "suggest", "that", "C0171016#ent", "<e1>", "acts", "as", "a", "reversible", "mu", "C0243192#ent", "<e2>", "with", "a", "relatively", "slow", "onset", "and", "a", "duration", "of", "action", "and", "relative", "efficacy", "similar", "to", "those", "of", "morphine", "in", "rhesus", "monkeys"], "h": {"id": "C0171016", "name": "C0171016#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [11, 12]}}
{"token": ["This", "effect", "is", "not", "mediated", "through", "a", "cAMP", "metabolite", "since", "a", "membrane-permeable", "form", "of", "C4084937#ent", "<e1>", "had", "no", "effect", "H3", "phosphorylation", "a", "C0757672#ent", "<e2>", "cAMP", "analog", "reduced", "it", "."], "h": {"id": "C4084937", "name": "C4084937#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0757672", "name": "C0757672#ent", "pos": [22, 23]}}
{"token": ["To", "report", "an", "C0021400#ent", "<e1>", "associated", "myocarditis", "and", "severe", "C0949660#ent", "<e2>"], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0949660", "name": "C0949660#ent", "pos": [9, 10]}}
{"token": ["Biochemical", "study", "has", "revealed", "a", "high", "activity", "of", "C1420521#ent", "<e1>", "in", "the", "C0023899#ent", "<e2>", ",", "heart", "and", "kidney", "with", "lesser", "activity", "in", "other", "tissues", "."], "h": {"id": "C1420521", "name": "C1420521#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}}
{"token": ["The", "isoprenoid", "quinones", "C1875400#ent", "<e1>", "6T19", "T", "were", "MK-9", ",", "MK-8", ",", "MK-7", ",", "C1704805#ent", "<e2>", "and", "MK-6", "(", "45:27:18:5:4", "%", ")", ",", "the", "peptidoglycan", "type", "L-lys<--D-Asp", "and", "the", "main", "cellular", "fatty", "acid", "i-C(16:0", ")", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704805", "name": "C1704805#ent", "pos": [14, 15]}}
{"token": ["Analysis", "of", "nuclear", "extracts", "that", "activator", "protein", "was", "reduced", "in", "TLR2-neutralized", "monocytic", "cells", ",", "suggesting", "that", "C0162508#ent", "<e1>", "plays", "a", "role", "in", "the", "transcriptional", "activation", "MMP-9", "through", "C1336634#ent", "<e2>", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1336634", "name": "C1336634#ent", "pos": [27, 28]}}
{"token": ["The", "T", "F", "L", "flap", "was", "used", "in", "the", "second", "case", "to", "resurface", "a", "left", "trochanteric", "bedsore", "in", "a", "patient", "recovering", "from", "C0037771#ent", "<e1>", "sustained", "from", "an", "attack", "of", "C0026976#ent", "<e2>"], "h": {"id": "C0037771", "name": "C0037771#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0026976", "name": "C0026976#ent", "pos": [29, 30]}}
{"token": ["Within", "C1335654#ent", "<e1>", ",", "S48", ",", "S303", ",", "and", "S424", "fit", "the", "C0080054#ent", "<e2>", "cdk", ")", "phosphorylation", "consensus", ",", "(S/T)PX(R/K", ")", "."], "h": {"id": "C1335654", "name": "C1335654#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [12, 13]}}
{"token": ["This", "study", "confirms", "that", "C3540471#ent", "<e1>", "may", "represent", "the", "availability", "of", "useful", "real-time", "technology", "study", "conjunctival", "microvascular", "abnormalities", "C0162819#ent", "<e2>", "juvenile", "as", "well", "as", "adult", "patients", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0162819", "name": "C0162819#ent", "pos": [18, 19]}}
{"token": ["The", "therapeutic", "potential", "of", "C2347556#ent", "<e1>", "has", "been", "described", "previously", "for", "several", "C0033581#ent", "<e2>", "but", "the", "molecular", "mechanisms", "the", "anti-inflammatory", "properties", "C2347556#ent", "<e1>", "are", "not", "well", "understood", "."], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2347556", "name": "C2347556#ent", "pos": [4, 5]}}
{"token": ["Steroid", "pulse", "oral", "C0032950#ent", "<e1>", "treatment", "resulted", "in", "ameriolation", "of", "cerebral", "complications", "as", "disorientation", "and", "C4048158#ent", "<e2>", ",", "but", "muscle", "weakness", "paresthesia", "in", "the", "lower", "limbs", "urinary", "retention", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4048158", "name": "C4048158#ent", "pos": [15, 16]}}
{"token": ["During", "storage", "of", "CSF", "and", "plasma", "the", "single", "cys-10", "in", "the", "C0599220#ent", "<e1>", "an", "extra", "negative", "charge", "and", "became", "unreactive", "towards", "C1414177#ent", "<e2>", "due", "to", "oxidation", "mainly", "without", "formation", "of", "disulphides", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414177", "name": "C1414177#ent", "pos": [21, 22]}}
{"token": ["Membrane", "angiotensin", "II", "receptors", "measured", "in", "human", "placenta", "by", "means", "of", "125I", "[", "Sar1", "Ile8", "]", "All", "(", "C0521942#ent", "<e1>", "and", "characterized", "by", "using", "2", "other", "antagonists", "of", "angiotensin", "II", "C0700620#ent", "<e2>", "CGP", "42112A", "."], "h": {"id": "C0521942", "name": "C0521942#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0700620", "name": "C0700620#ent", "pos": [30, 31]}}
{"token": ["C1417708#ent", "<e1>", "elevated", "in", "mice", "fed", "a", "C0042842#ent", "<e2>", "VAD", ")", "diet", ",", "and", "suppressed", "by", "surplus", "doses", "of", "retinoic", "acid", "RA", ")", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042842", "name": "C0042842#ent", "pos": [7, 8]}}
{"token": ["The", "ability", "of", "C0004259#ent", "<e1>", "to", "inhibit", "C0015263#ent", "<e2>", "evaluated", "in", "18", "children", "with", "chronic", ",", "perennial", "asthma"], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015263", "name": "C0015263#ent", "pos": [7, 8]}}
{"token": ["C0044549#ent", "<e1>", ")", "is", "an", "analogue", "of", "the", "naturally", "occurring", "C0024361#ent", "<e2>", "belonging", "to", "the", "class", "of", "antitumor", "lipids"], "h": {"id": "C0044549", "name": "C0044549#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024361", "name": "C0024361#ent", "pos": [10, 11]}}
{"token": ["04", ")", "in", "C1515406#ent", "<e1>", "induced", "reporter", "expression", "in", "both", "C0525678#ent", "<e2>", "transfected", "cell", "lines", "."], "h": {"id": "C1515406", "name": "C1515406#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}}
{"token": ["C3830285#ent", "<e1>", "(", "a", "progesterone", "antagonist", "or", "ICI", "182780", "an", "C0014930#ent", "<e2>", "administered", "to", "guinea-pigs", "on", "days", "11", "-", "14", "of", "the", "cycle", "significantly", "reduced", "uterine", "PGF2", "alpha", "output", "on", "day", "15", "."], "h": {"id": "C3830285", "name": "C3830285#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014930", "name": "C0014930#ent", "pos": [10, 11]}}
{"token": ["These", "are", "domains", "comprised", "of", "about", "160", "amino", "acids", "are", "present", "in", "C0021699#ent", "<e1>", "as", "the", "meprins", "and", "C0289499#ent", "<e2>", "where", "they", "appear", "to", "function", "in", "cell/cell", "interactions", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [12, 13]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C0289499", "name": "C0289499#ent", "pos": [18, 19]}}
{"token": ["Northern", "blot", "hybridization", "employing", "(32)P-labeled", "cDNA", "probes", ",", "showed", "that", "C1412277#ent", "<e1>", "steady-state", "mRNA", "levels", "were", "increased", "by", "forskolin", "and", "C0000096#ent", "<e2>", "after", "1", "h", "and", "5", "h", "incubation", "."], "h": {"id": "C1412277", "name": "C1412277#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0000096", "name": "C0000096#ent", "pos": [20, 21]}}
{"token": ["This", "report", "describes", "a", "71-year-old", "man", "with", "rapidly", "C0221239#ent", "<e1>", "RPGN", ")", "and", "C0206061#ent", "<e2>", "associated", "with", "MPO", "ANCA", "."], "h": {"id": "C0221239", "name": "C0221239#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "the", "present", "study", "demonstrated", "that", "the", "antinociceptive", "effect", "of", "C0006949#ent", "<e1>", "is", "enhanced", "by", "combination", "with", "imipramine", ",", "C0085228#ent", "<e2>", "and", "milnacipran", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085228", "name": "C0085228#ent", "pos": [20, 21]}}
{"token": ["Acetylation", "increased", "the", "5HT", "releasing", "effect", "of", "amphetamine", ",", "C0033798#ent", "<e1>", "and", "tyramine", "but", "decreased", "this", "effect", "of", "phenylephrine", "and", "C0029193#ent", "<e2>", "."], "h": {"id": "C0033798", "name": "C0033798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029193", "name": "C0029193#ent", "pos": [20, 21]}}
{"token": ["A", "45", "year", "old", "patient", "wad", "admitted", "with", "C0232495#ent", "<e1>", "a", "palpable", "mass", "the", "epigastrium", "of", "3", "months", "C0720099#ent", "<e2>", "."], "h": {"id": "C0232495", "name": "C0232495#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [18, 19]}}
{"token": ["If", "lactate", "was", "detectable", "in", "the", "culture", "broth", "C0017789#ent", "<e1>", "was", "not", ",", "poly-hydroxy-butyrate", "(", "C1335208#ent", "<e2>", ")", "was", "formed", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335208", "name": "C1335208#ent", "pos": [15, 16]}}
{"token": ["Haemorrhages", "in", "the", "upper", "GI", "tract", "lead", "to", "severe", "C0042749#ent", "<e1>", "and", ",", "in", "patients", "with", "liver", "failure", "to", "C0220994#ent", "<e2>", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0220994", "name": "C0220994#ent", "pos": [19, 20]}}
{"token": ["The", "downregulation", "of", "PDEF", ",", "PSA", ",", "C1705316#ent", "<e1>", "and", "IGF-1", "receptor", "gene", "expression", "by", "tectorigenin", "demonstrates", "the", "C0003392#ent", "<e2>", "these", "agents", "."], "h": {"id": "C1705316", "name": "C1705316#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [18, 19]}}
{"token": ["To", "determine", "whether", "C1415619#ent", "<e1>", "induction", "resulted", "in", "a", "decrease", "in", "C0051844#ent", "<e2>", "II-stimulated", "ROS", "generation", "in", "the", "renal", "medulla", "superoxide", "production", "measured", "."], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [11, 12]}}
{"token": ["C0050652#ent", "<e1>", "also", "inhibited", "with", "an", "IC50", "value", "of", "1.1", "microM", "C0165270#ent", "<e2>", "tested", "on", "whole", "brain", "homogenate", "of", "rats", "in", "the", "presence", "of", "thiorphan", "and", "bestatin", "."], "h": {"id": "C0050652", "name": "C0050652#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0165270", "name": "C0165270#ent", "pos": [11, 12]}}
{"token": ["One", "case", "each", "of", "C0030804#ent", "<e1>", "BMMP", ")", "and", "C0206139#ent", "<e2>", "RLP", ")", "served", "as", "examples", "to", "demonstrate", "the", "applicability", "of", "this", "methodology", "."], "h": {"id": "C0030804", "name": "C0030804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0206139", "name": "C0206139#ent", "pos": [9, 10]}}
{"token": ["5", "CBZ", "appears", "to", "have", "a", "marked", "C0027203#ent", "<e1>", "inducing", "effect", "in", "young", "epileptics", "indicated", "by", "C0003420#ent", "<e2>", "kinetics", "and", "6", "beta-hydroxycortisol", "excretion", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003420", "name": "C0003420#ent", "pos": [16, 17]}}
{"token": ["The", "study", "by", "SSCP", "of", "STR", "in", "loci", "CSF1PO", ",", "C0812295#ent", "<e1>", ",", "and", "THO1", "and", "the", "C0002085#ent", "<e2>", "of", "locus", "DIS80", "is", "shown", "in", "a", "representative", "case", "of", "paternity", "dispute", "."], "h": {"id": "C0812295", "name": "C0812295#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [17, 18]}}
{"token": ["C1959635#ent", "<e1>", "recently", "been", "implicated", "in", "various", "vasculitic", "syndromes", "C2721603#ent", "<e2>", "HSP", ")", ",", "Wegener's", "granulomatosis", "microscopic", "polyarteritis"], "h": {"id": "C1959635", "name": "C1959635#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2721603", "name": "C2721603#ent", "pos": [9, 10]}}
{"token": ["Side", "effects", "throat", "irritation", "flushing", ",", "and", "C0270697#ent", "<e1>", "were", "more", "frequent", "with", "histamine", "than", "C0600370#ent", "<e2>", ",", "and", "were", "dose-related", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0600370", "name": "C0600370#ent", "pos": [15, 16]}}
{"token": ["This", "contrasts", "markedly", "with", "Bloom's", "syndrome", "BLM", ")", "patients", ",", "whose", "C1367455#ent", "<e1>", "and", "TCR", "C0024796#ent", "<e2>", "were", "previously", "reported", "to", "increase", "about", "50-", "and", "15-fold", ",", "respectively", "."], "h": {"id": "C1367455", "name": "C1367455#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [15, 16]}}
{"token": ["During", "extinction", "learning", ",", "some", "C1413366#ent", "<e1>", "neurons", "enhanced", "or", "reversed", "the", "responses", "to", "C2605495#ent", "<e2>", "in", "the", "stressed", "rats", ",", "whereas", "no", "C1413366#ent", "<e1>", "neurons", "showed", "such", "response", "changes", "in", "the", "control", "rats"], "h": {"id": "C1413366", "name": "C1413366#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2605495", "name": "C2605495#ent", "pos": [14, 15]}}
{"token": ["Mutations", "in", "the", "fibrillar", "collagen", "genes", "COL11A1", "and", "C1413571#ent", "<e1>", "can", "cause", "C0018784#ent", "<e2>", "associated", "with", "Stickler", "syndrome"], "h": {"id": "C1413571", "name": "C1413571#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [12, 13]}}
{"token": ["GF", "I", "C1336620#ent", "<e1>", "TGFalpha", ")", ",", "insulin-like", "growth", "factor", "type", "one", "IGF-1", ")", ",", "and", "retinoic", "acid", "C0003873#ent", "<e2>", ")", ",", "whereas", "GF", "II", "those", "three", "factors", "and", "brain-derived", "neurotrophic", "factor"], "h": {"id": "C1336620", "name": "C1336620#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [18, 19]}}
{"token": ["Patients", "with", "familial", "Mediterranean", "fever", "take", "daily", "multiple", "doses", "C0009262#ent", "<e1>", "to", "prevent", "acute", "attacks", "to", "reduce", "the", "risk", "of", "C0002726#ent", "<e2>", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [20, 21]}}
{"token": ["Moreover", ",", "the", "decay", "of", "C1417932#ent", "<e1>", "activity", "in", "the", "cells", "treated", "with", "phytohemagglutinin", "plus", "dibutyryl", "cyclic", "C4285220#ent", "<e2>", "and", "3-isobutyl-1-methylxanthine", "was", "significantly", "slower", "than", "that", "of", "control", "cells", "stimulated", "with", "phytohemagglutinin", "alone", "."], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4285220", "name": "C4285220#ent", "pos": [17, 18]}}
{"token": ["Indinavir", ",", "which", "also", "was", "metabolized", "predominantly", "by", "CYP3A", "enzymes", ",", "extensively", "inhibited", "C0044729#ent", "<e1>", "metabolism", "in", "microsomes", ",", "whereas", "C0044729#ent", "<e1>", "weak", "inhibitory", "potency", "on", "C0700483#ent", "<e1>", "metabolism", "."], "h": {"id": "C0044729", "name": "C0044729#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0700483", "name": "C0700483#ent", "pos": [26, 27]}}
{"token": ["Therefore", "we", "can", "describe", "particular", "alterations", "of", "the", "thyroidal", "pattern", "typical", "of", "chronic", "liver", "diseases", "C0024043#ent", "<e1>", "low", "T3", "and", "C0039082#ent", "<e2>", "high", "T4", "syndrome", "mixed", "forms"], "h": {"id": "C0024043", "name": "C0024043#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [20, 21]}}
{"token": ["We", "propose", "that", "external", "signals", "can", "partly", "segregate", "two", "C3812755#ent", "<e1>", "pathways", "by", "modulating", "C1423839#ent", "<e2>", "expression", "and", "that", "GEFs", "can", "influence", "how", "Ras", "is", "coupled", "to", "specific", "effectors", "."], "h": {"id": "C3812755", "name": "C3812755#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1423839", "name": "C1423839#ent", "pos": [14, 15]}}
{"token": ["Seven", "weeks", "later", ",", "an", "anterior", "vitrectomy", "removal", "of", "the", "IOL", "was", "performed", "because", "of", "C0014236#ent", "<e1>", "resistant", "to", "topical", "and", "systemic", "amoxicillin", ",", "cephalosporin", ",", "C3536835#ent", "<e2>", ",", "and", "steroids", "."], "h": {"id": "C0014236", "name": "C0014236#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3536835", "name": "C3536835#ent", "pos": [26, 27]}}
{"token": ["Pretreatment", "with", "either", "systemic", "or", "topical", "C1161352#ent", "<e1>", "prevented", "the", "C1421143#ent", "<e2>", "or", "a-VP", "induced", "increase", "in", "IOP", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [10, 11]}}
{"token": ["The", "types", "of", "C0002871#ent", "<e1>", "seen", "and", "their", "mechanisms", "are", "discussed", ":", "C0085576#ent", "<e2>", "to", "disturbed", "iron", "metabolism", "to", "its", "impaired", "intestinal", "absorption", "normocytic", "anaemia", "macrocytic", "anaemia", "preceding", "pernicious", "anaemia"], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0085576", "name": "C0085576#ent", "pos": [12, 13]}}
{"token": ["C0587248#ent", "<e1>", "complicate", "fatal", "C0007194#ent", "<e2>"], "h": {"id": "C0587248", "name": "C0587248#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0007194", "name": "C0007194#ent", "pos": [4, 5]}}
{"token": ["Conditions", "of", "the", "obtaining", "polymer", "compositions", ",", "containing", "C0257770#ent", "<e1>", "lysozyme", "and", "C0032594#ent", "<e2>", "alginate", "and", "their", "properties", "were", "developed", "and", "investigated", "."], "h": {"id": "C0257770", "name": "C0257770#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [12, 13]}}
{"token": ["To", "better", "understand", "the", "inflammatory", "process", "we", "recently", "introduced", "a", "profiling", "methodology", "to", "identify", "common", "C1417679#ent", "<e1>", "involved", "in", "C0010692#ent", "<e2>"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010692", "name": "C0010692#ent", "pos": [19, 20]}}
{"token": ["C1415286#ent", "<e1>", "mainly", "responsible", "of", "C0451641#ent", "<e2>", "."], "h": {"id": "C1415286", "name": "C1415286#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0451641", "name": "C0451641#ent", "pos": [5, 6]}}
{"token": ["C4082270#ent", "<e1>", "is", "highly", "perishable", "when", "exposed", "to", "air", ",", "generating", "C3539984#ent", "<e2>", "which", "can", "degrade", "amino", "acids", "mainly", "lysine", ",", "leading", "to", "uncertainty", "in", "chromatogram", "interpretations", "."], "h": {"id": "C4082270", "name": "C4082270#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3539984", "name": "C3539984#ent", "pos": [11, 12]}}
{"token": ["Here", "we", "report", "that", "IL-27", "upregulated", "IL-10", "in", "effector", "T", "cells", "produced", "interferon-gamma", "and", "expressed", "the", "transcription", "factor", "C1420610#ent", "<e1>", "but", "did", "not", "express", "the", "transcription", "factor", "C1416467#ent", "<e2>", "."], "h": {"id": "C1420610", "name": "C1420610#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1416467", "name": "C1416467#ent", "pos": [27, 28]}}
{"token": ["Real-time", "quantitative", "reverse", "transcription-polymerase", "chain", "reaction", "decrease", "in", "matrix", "metalloproteinase-1", "mRNA", "levels", "by", "pretreatment", "with", "both", "C0991617#ent", "<e1>", ",", "but", "mRNA", "levels", "of", "tissue", "inhibitor", "C2001899#ent", "<e2>", "-2", "were", "differently", "modulated", "by", "interferon-alpha", "and", "sodium", "butyrate"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [25, 26]}}
{"token": ["In", "cell", "culture", "systems", "the", "C0170168#ent", "<e1>", "ERK", ")", "and", "C3539803#ent", "<e2>", "RSK", ")", "couple", "synaptic", "signals", "CRE-mediated", "gene", "expression", "modulating", "CRE-binding", "protein", "CREB", ")", "phosphorylation", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539803", "name": "C3539803#ent", "pos": [10, 11]}}
{"token": ["Activation", "of", "C0170168#ent", "<e1>", "demonstrated", "to", "lead", "to", "the", "downstream", "activation", "of", "p90", "RSK", "C3539803#ent", "<e2>", "as", "well", "as", "ATF-1", "and", "CREB", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539803", "name": "C3539803#ent", "pos": [14, 15]}}
{"token": ["These", "stretch-induced", "endothelium", "dependent", "tissue", "cGMP", "elevations", "were", "unaffected", "by", "Ca2", "+", "C2985407#ent", "<e1>", "nicardipine", "and", "C0282138#ent", "<e2>", "."], "h": {"id": "C2985407", "name": "C2985407#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [16, 17]}}
{"token": ["Since", "C1334879#ent", "<e1>", "was", "recently", "shown", "to", "undergo", "C0379528#ent", "<e2>", "regulated", "intramembrane", "proteolysis", "this", "study", "examines", "the", "effect", "of", "familial", "Alzheimer", "mutations", "on", "processing", "of", "C1334879#ent", "<e1>", "."], "h": {"id": "C1334879", "name": "C1334879#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0379528", "name": "C0379528#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "blockers", "of", "lipoxygenase", "(", "nordihydroguaiaretic", "acid", "NDGA", ";", "C0050341#ent", "<e1>", ")", "or", "lipoxygenase", "plus", "cyclooxygenase", "BW755C", ";", "eicosatetraynoic", "acid", "ETYA", ")", "on", "C1955949#ent", "<e2>", "of", "beta-End-IR", "were", "diverse", "."], "h": {"id": "C0050341", "name": "C0050341#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1955949", "name": "C1955949#ent", "pos": [25, 26]}}
{"token": ["In", "addition", ",", "C0001622#ent", "<e1>", "of", "the", "normal", "product", "some", "C0029016#ent", "<e2>", "may", "be", "a", "factor", "in", "the", "development", "of", "cancer", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [10, 11]}}
{"token": ["PLTP", "and", "C1412481#ent", "<e1>", "play", "important", "roles", "in", "lipoprotein", "metabolism", "C0004153#ent", "<e2>", "."], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [2, 3]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [10, 11]}}
{"token": ["Consequently", ",", "a", "concerted", "action", "either", "of", "PLA2", "and", "CEL", "or", "of", "C1423073#ent", "<e1>", "and", "CEL", "made", "the", "substrate", "cholesteryl", "C0220884#ent", "<e2>", "available", "for", "hydrolysis", "by", "CEL", "."], "h": {"id": "C1423073", "name": "C1423073#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0220884", "name": "C0220884#ent", "pos": [20, 21]}}
{"token": ["Common", "variable", "immunodeficiency", "disorder", "CVID", ")", "is", "an", "C0021053#ent", "<e1>", "can", "present", "with", "gastrointestinal", "(GI)", "symptoms", "including", "chronic", "diarrhea", "C0000737#ent", "<e2>"], "h": {"id": "C0021053", "name": "C0021053#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [19, 20]}}
{"token": ["The", "most", "common", "infections", "in", "these", "patients", "were", "C0032285#ent", "<e1>", ",", "septicemia", ",", "peritonitis", "and", "C1141927#ent", "<e2>"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1141927", "name": "C1141927#ent", "pos": [15, 16]}}
{"token": ["The", "right", "atrial", "wall", "partially", "resected", ",", "contained", "few", "C0231531#ent", "<e1>", "showed", "patchy", "C0014117#ent", "<e2>", "."], "h": {"id": "C0231531", "name": "C0231531#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014117", "name": "C0014117#ent", "pos": [13, 14]}}
{"token": ["C1517755#ent", "<e1>", "11beta-hydroxysteroid", "dehydrogenase", "type", "1", "11beta-HSD1", ")", "have", "considerable", "potential", "as", "treatments", "for", "C0025517#ent", "<e2>", "such", "as", "diabetes", "mellitus", "type", "2", "obesity", "."], "h": {"id": "C1517755", "name": "C1517755#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [14, 15]}}
{"token": ["The", "90-kDa", "protein", "induced", "by", "Cd", "reacted", "negatively", "with", "three", "monoclonal", "antibodies", "C3273507#ent", "<e1>", "and", "was", "subsequently", "identified", "as", "a", "C1333935#ent", "<e2>", "grp94", ")", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333935", "name": "C1333935#ent", "pos": [20, 21]}}
{"token": ["We", "did", "not", "find", "any", "regulation", "of", "the", "C1705547#ent", "<e1>", "promoter", "region", "by", "SRIF", ",", "forskolin", ",", "C0872913#ent", "<e2>", ",", "IGF-1", ",", "EGF", ",", "T3", ",", "glucocorticoids", "or", "17beta-estradiol", "."], "h": {"id": "C1705547", "name": "C1705547#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0872913", "name": "C0872913#ent", "pos": [17, 18]}}
{"token": ["The", "modifying", "effects", "of", "exposure", "to", "two", "natural", "products", "C0072489#ent", "<e1>", "PCA", ")", "and", "C0056413#ent", "<e2>", "during", "the", "development", "of", "neoplasms", "in", "oral", "carcinogenesis", "with", "7,12-dimethylbenz[a]anthracene", "(", "DMBA", ")", "were", "investigated", "in", "male", "Syrian", "golden", "hamsters"], "h": {"id": "C0072489", "name": "C0072489#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0056413", "name": "C0056413#ent", "pos": [14, 15]}}
{"token": ["This", "assay", "should", "be", "useful", "for", "generic", "analysis", "N-", "and", "C0030018#ent", "<e1>", "activities", "of", "xenobiotic", "and", "endobiotic", "chemicals", "by", "C0796517#ent", "<e2>", "enzymes", "."], "h": {"id": "C0030018", "name": "C0030018#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0796517", "name": "C0796517#ent", "pos": [19, 20]}}
{"token": ["Indirect", "signs", "C3714497#ent", "<e1>", "from", "changes", "in", "the", "lung", "parenchyma", "distal", "to", "the", "C0012634#ent", "<e2>", "small", "airway", "include", "air", "trapping", "subsegmental", "atelectasis", ",", "centrilobular", "emphysema", "and", "air-space", "nodules", "."], "h": {"id": "C3714497", "name": "C3714497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [13, 14]}}
{"token": ["C1413167#ent", "<e1>", "treatment", "produced", "the", "expected", "marked", "rise", "in", "plasma", "C1705587#ent", "<e2>", "levels", "in", "control", "rats", "pretreated", "intracerebroventricularly", "with", "artificial", "cerebrospinal", "fluid"], "h": {"id": "C1413167", "name": "C1413167#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705587", "name": "C1705587#ent", "pos": [10, 11]}}
{"token": ["Here", "we", "demonstrate", "that", "overexpression", "of", "C3538887#ent", "<e1>", "activates", "NF-kappaB", "and", "stress-activated", "protein", "kinase", "C1367731#ent", "<e2>", "JNK", ")", "."], "h": {"id": "C3538887", "name": "C3538887#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [14, 15]}}
{"token": ["Microsomes", "from", "rat", "and", "mouse", "C0023899#ent", "<e1>", "were", "incubated", "in", "a", "sealed", "vial", "with", "C0042510#ent", "<e2>", "and", "an", "NADPH-regenerating", "system", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042510", "name": "C0042510#ent", "pos": [14, 15]}}
{"token": ["It", "is", "possible", "therefore", "that", "sensitization", "to", "antigens", "other", "than", "C1420131#ent", "<e1>", "play", "a", "part", "in", "the", "pathogenesis", "of", "C0520463#ent", "<e2>"], "h": {"id": "C1420131", "name": "C1420131#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0520463", "name": "C0520463#ent", "pos": [19, 20]}}
{"token": ["The", "lateral", "nucleus", "the", "amygdala", "(", "C1420423#ent", "<e1>", ")", "receives", "axonal", "projections", "from", "the", "auditory", "thalamus", "the", "medial", "geniculate", "nucleus", "C2681564#ent", "<e2>", ")", ",", "and", "mediates", "auditory", "fear", "conditioning", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2681564", "name": "C2681564#ent", "pos": [20, 21]}}
{"token": ["These", "results", "suggest", "that", "aptamer", "C1420563#ent", "<e1>", "has", "inhibitory", "effects", "on", "M.", "tuberculosis", "can", "be", "used", "as", "C0360390#ent", "<e2>"], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0360390", "name": "C0360390#ent", "pos": [17, 18]}}
{"token": ["We", "have", "determined", "C0311370#ent", "<e1>", "anti-beta2", "glycoprotein", "I", "beta2GPI", ")", "and", "antiprothrombin", "antibodies", "in", "the", "C0398623#ent", "<e2>", "a", "population-based", "case-control", "study", "to", "determine", "risk", "factors", "deep", "venous", "thrombosis", "DVT", ")", "."], "h": {"id": "C0311370", "name": "C0311370#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0398623", "name": "C0398623#ent", "pos": [15, 16]}}
{"token": ["Importantly", ",", "a", "striking", "increase", "in", "the", "expression", "of", "specific", "C0255873#ent", "<e1>", ",", "LAR", "and", "C1335281#ent", "<e2>", ",", "was", "observed", "in", "3", "independently", "neu", "transformed", "cell", "lines", "their", "derived", "tumors", "."], "h": {"id": "C0255873", "name": "C0255873#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335281", "name": "C1335281#ent", "pos": [15, 16]}}
{"token": ["C0812325#ent", "<e1>", "mRNA", "expression", "analyses", "revealed", "a", "higher", "expression", "of", "C1332089#ent", "<e2>", "low-grade", "CC-RCC", "."], "h": {"id": "C0812325", "name": "C0812325#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332089", "name": "C1332089#ent", "pos": [10, 11]}}
{"token": ["C0018889#ent", "<e1>", "more", "susceptible", "to", "C0038880#ent", "<e2>", "than", "female", "worms"], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [5, 6]}}
{"token": ["of", "C0699604#ent", "<e1>", "Neoral", "(", "NEO", ")", ",", "Novartis", "Pharma", "and", "C0751039#ent", "<e2>", "(", "United", "States", "Pharmacopeia", "modified", ",", "Eon", "Labs", "EON", ")", ",", "as", "capsules", "dissolved", "in", "water", "by", "oral", "gavage"], "h": {"id": "C0699604", "name": "C0699604#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [11, 12]}}
{"token": ["Inhibition", "of", "mitochondrial", "ROS", "generation", "with", "rotenone", "or", "C0067087#ent", "<e1>", "prevented", "hypoxic", "activation", "of", "C0063555#ent", "<e2>", "."], "h": {"id": "C0067087", "name": "C0067087#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0063555", "name": "C0063555#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "have", "used", "pure", "alpha", ",", "epsilon", ",", "and", "tau", "subunits", "in", "binding", "studies", "to", "determine", "whether", "C1446659#ent", "<e1>", "can", "dimerize", "the", "C1335440#ent", "<e2>", "."], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [24, 25]}}
{"token": ["Sixteen", "cases", "revealed", "various", "types", "of", "brain", "pathology", "as", "C0019151#ent", "<e1>", "traumatic", "cortical", "scars", ",", "C0206083#ent", "<e2>", "."], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0206083", "name": "C0206083#ent", "pos": [15, 16]}}
{"token": ["The", "most", "significant", "C0035064#ent", "<e1>", "are", "verapamil", ",", "gallopamil", ",", "nifedipine", ",", "diltiazem", "and", "C0145904#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0145904", "name": "C0145904#ent", "pos": [14, 15]}}
{"token": ["Although", "no", "disulfide-linked", "association", "was", "observed", "between", "GPIbbeta", "Ser122", "C4281938#ent", "<e1>", ",", "GPIbbeta", "Ser122", "non-covalently", "associated", "with", "C4281938#ent", "<e1>", "and", "GPIX", "subunits", "the", "cell", "surface", "cotransfected", "with", "C2987364#ent", "<e1>", "C4281938#ent", "<e1>", "and", "GPIX", "."], "h": {"id": "C4281938", "name": "C4281938#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [27, 28]}}
{"token": ["C0486797#ent", "<e1>", ",", "sertraline", "and", "fluvoxamine", "inhibited", "C0919425#ent", "<e2>", "(", "7-ethoxyresorufin", "O-deethylase", "in", "microsomes", "from", "human", "placenta", "(", "IC50", "values", "29", "microM", ",", "35", "microM", "and", "80", "microM", ",", "respectively", ")", "."], "h": {"id": "C0486797", "name": "C0486797#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919425", "name": "C0919425#ent", "pos": [7, 8]}}
{"token": ["We", "studied", "the", "antihistaminic", "property", "of", "a", "new", "compound", ",", "C0052762#ent", "<e1>", ",", "on", "histamine-induced", "bronchoconstriction", "and", "compared", "it", "with", "C0022642#ent", "<e2>", "and", "placebo", "."], "h": {"id": "C0052762", "name": "C0052762#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022642", "name": "C0022642#ent", "pos": [20, 21]}}
{"token": ["Serious", "complications", "pneumonia", ",", "presumed", "viral", "(", "67", "%", ")", ",", "secondary", "C0004623#ent", "<e1>", "shock", ",", "cardiomyopathy", ",", "myocarditis", "and", "C0020616#ent", "<e2>", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [20, 21]}}
{"token": ["Bacterially", "expressed", "recombinant", "C1367476#ent", "<e1>", "exerted", "the", "C1528775#ent", "<e2>", "and", "GTPase", "activities", "."], "h": {"id": "C1367476", "name": "C1367476#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1528775", "name": "C1528775#ent", "pos": [7, 8]}}
{"token": ["The", "patient's", "findings", "were", "compatible", "with", "a", "rare", "C1848862#ent", "<e1>", "designated", "as", "C0268436#ent", "<e2>", "Gordon's", "syndrome"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268436", "name": "C0268436#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "C1366487#ent", "<e1>", ",", "FAPalpha", ",", "and", "DPPIV", "are", "related", "C1622401#ent", "<e2>", "that", "C1366487#ent", "<e1>", "is", "similar", "to", "DPPIV", ",", "the", "proteolytic", "activities", "which", "are", "dependent", "upon", "subunit", "association", "."], "h": {"id": "C1366487", "name": "C1366487#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1622401", "name": "C1622401#ent", "pos": [12, 13]}}
{"token": ["To", "evaluate", "Ped/pea-15", "(", "C0031686#ent", "<e1>", "enriched", "in", "C0011847#ent", "<e2>", ")", "expression", "in", "polycystic", "ovary", "syndrome", "PCOS", ")", "women", "."], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [8, 9]}}
{"token": ["To", "elucidate", "the", "role", "of", "anti-endothelial", "cell", "antibodies", "(", "AECA", ")", "in", "C0042384#ent", "<e1>", "patients", "with", "Wegener's", "granulomatosis", "C3495801#ent", "<e2>", ")", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C3495801", "name": "C3495801#ent", "pos": [18, 19]}}
{"token": ["Studies", "in", "C0019187#ent", "<e1>", "suggest", "a", "hit-and-run", "effect", "of", "alcohol", ",", "whereas", "other", "C0008679#ent", "<e2>", "evidence", "of", "gradual", "increase", "in", "prevalence", "of", "Mallory", "bodies", "severity", "of", "hepatic", "pathology"], "h": {"id": "C0019187", "name": "C0019187#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [13, 14]}}
{"token": ["Our", "data", "demonstrate", "that", "14", "-", "3", "-", "3zeta", "mediates", "C1446659#ent", "<e1>", "phosphorylation", "by", "Ser9-phosphorylated", "C0244988#ent", "<e2>", "in", "HEK-293", "cells", "."], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [15, 16]}}
{"token": ["It", "suggests", "that", "betaE2", "may", "arrest", "AD-like", "C1446659#ent", "<e1>", "hyperphosphorylation", "by", "directly", "targeting", "C0244988#ent", "<e2>", "."], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [13, 14]}}
{"token": ["Extraprostatic", "production", "C1426033#ent", "<e1>", "is", "provided", "mainly", "by", "the", "periurethral", "glands", "leading", "to", "measurable", "urine", "but", "undetectable", "serum", "levels", "C1426033#ent", "<e1>", "in", "women", "and", "in", "men", "following", "radical", "prostatectomy", "C0277565#ent", "<e1>"], "h": {"id": "C1426033", "name": "C1426033#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [29, 30]}}
{"token": ["C0297817#ent", "<e1>", "RR", ")", "small", "subunits", ",", "M2", "and", "C1424883#ent", "<e2>", ",", "play", "key", "roles", "in", "forming", "RR", "holoenzyme", "supplying", "nucleotide", "precursors", "for", "DNA", "replication", "repair", "."], "h": {"id": "C0297817", "name": "C0297817#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424883", "name": "C1424883#ent", "pos": [9, 10]}}
{"token": ["C0030858#ent", "<e1>", "degradation", "was", "approximately", "ten", "times", "slower", "in", "rat", "plasma", "than", "in", "rat", "blood", ",", "suggesting", "that", "C3541394#ent", "<e2>", "in", "erythrocytes", "are", "important", "for", "C0030858#ent", "<e1>", "metabolism", "in", "rat", "whole", "blood"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0030858", "name": "C0030858#ent", "pos": [0, 1]}}
{"token": ["To", "examine", "stress-related", "neurohormonal", "and", "metabolic", "effects", "of", "butorphanol", ",", "C0015846#ent", "<e1>", ",", "and", "ketamine", "administration", "alone", "and", "in", "combination", "with", "C0113293#ent", "<e2>", "in", "dogs", "."], "h": {"id": "C0015846", "name": "C0015846#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0113293", "name": "C0113293#ent", "pos": [21, 22]}}
{"token": ["Possible", "explanations", "for", "combined", "HTCII", "and", "25(OH)D", "C0268487#ent", "<e1>", "include", "patient", "age", "presence", "of", "C0017154#ent", "<e2>", "and", "lack", "of", "sun", "exposure"], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017154", "name": "C0017154#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "in", "certain", "C0029896#ent", "<e1>", "such", "as", "diabetes", "mellitus", "C0001623#ent", "<e2>", "incidence", "of", "pigmentation", "disorders", "higher", "than", "in", "the", "general", "population"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001623", "name": "C0001623#ent", "pos": [10, 11]}}
{"token": ["Tuberculosis", "and", "other", "potentially", "treatable", "C0029896#ent", "<e1>", "remain", "important", "causes", "of", "C0001623#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001623", "name": "C0001623#ent", "pos": [11, 12]}}
{"token": ["TNPA", "caused", "dose-dependent", "suppression", "of", "contractions", "of", "the", "cat", "nictitans", "which", "was", "inhibited", "competitively", "by", "C0013015#ent", "<e1>", ",", "a", "relatively", "selective", "C1516869#ent", "<e2>"], "h": {"id": "C0013015", "name": "C0013015#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [21, 22]}}
{"token": ["A", "186-bp", "fragment", "from", "the", "human", "C0403399#ent", "<e1>", "promoter", "is", "capable", "of", "directing", "podocyte-specific", "expression", "of", "a", "C0005220#ent", "<e2>", "placed", "in", "front", "of", "a", "heterologous", "minimal", "promoter", "in", "transgenic", "mice"], "h": {"id": "C0403399", "name": "C0403399#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [17, 18]}}
{"token": ["In", "C0684275#ent", "<e1>", "A", ",", "the", "C0398711#ent", "<e2>", "the", "molecular", "level", "most", "factor", "VIII", "FVIII", ")", "missense", "mutations", "unknown", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0398711", "name": "C0398711#ent", "pos": [6, 7]}}
{"token": ["Elderly", ",", "debilitated", ",", "or", "C0010340#ent", "<e1>", "patients", "are", "at", "high", "risk", "hospital", "acquired", "or", "C0877203#ent", "<e2>"], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0877203", "name": "C0877203#ent", "pos": [15, 16]}}
{"token": ["Available", "data", "indicate", "that", "whereas", "in", "ulcerative", "colitis", "and", "to", "a", "lesser", "extent", "in", "C0156147#ent", "<e1>", "the", "innate", "immune", "response", "enhanced", ",", "it", "is", "C0907533#ent", "<e2>", "depressed", "in", "ileal", "Crohn's", "disease"], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [24, 25]}}
{"token": ["This", "novel", "C3539645#ent", "<e1>", "isoform", "is", "essential", "for", "Ag", "signaling", "through", "the", "C0524890#ent", "<e2>", "a", "costimulation-dependent", "fashion", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0524890", "name": "C0524890#ent", "pos": [12, 13]}}
{"token": ["C0014236#ent", "<e1>", "is", "a", "severe", "C0029877#ent", "<e2>", "profound", "visual", "consequences", "."], "h": {"id": "C0014236", "name": "C0014236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [5, 6]}}
{"token": ["Conversely", ",", "cytosolic", "C0007407#ent", "<e1>", "and", "MAO-B", "activities", "in", "the", "C0872351#ent", "<e2>", "are", "negligible", "and", "much", "lower", ",", "respectively", ",", "compared", "to", "activities", "in", "gray", "matter"], "h": {"id": "C0007407", "name": "C0007407#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [10, 11]}}
{"token": ["The", "impairment", "of", "the", "respiratory", "cardiac", "arrhythmia", "statistical", "relations", "the", "electroneurographic", "changes", "of", "somatic", "nerves", "to", "the", "duration", "of", "C0011849#ent", "<e1>", "and", "to", "the", "occurrence", "of", "C2717961#ent", "<e2>", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [26, 27]}}
{"token": ["C3830285#ent", "<e1>", "stimulated", "preterm", "labor", "increasing", "the", "iNOS", "and", "C1705323#ent", "<e2>", "mRNA", "(", "p<0.05", ")", "."], "h": {"id": "C3830285", "name": "C3830285#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [9, 10]}}
{"token": ["Osteoporosis", "in", "TM", "female", "was", "strongly", "associated", "with", "primary", "amenorrhea", "P", "<", ".0001", ")", ",", "while", "in", "male", "patients", "with", "C0151721#ent", "<e1>", "not", "significantly", "related", "to", "C1826421#ent", "<e2>", "(", "P", "=", ".0001", ")", "."], "h": {"id": "C0151721", "name": "C0151721#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1826421", "name": "C1826421#ent", "pos": [26, 27]}}
{"token": ["In", "contrast", "C1367482#ent", "<e1>", "enhanced", "forskolin", "stimulation", "of", "adenylate", "cyclase", "an", "effect", "previously", "linked", "with", "C0243192#ent", "<e2>", "activation", "of", "protein", "kinase", "C.", "effect", "of", "C1367482#ent", "<e1>", "on", "cellular", "cAMP", "was", "abolished", "by", "pre-incubation", "with", "pertussis", "toxin"], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1367482", "name": "C1367482#ent", "pos": [2, 3]}}
{"token": ["Diffuse", "white", "matter", "changes", "on", "brain", "imaging", "C0031117#ent", "<e1>", "associated", "features", "of", "merosin-deficient", "C1416776#ent", "<e2>", "CMD", ")", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416776", "name": "C1416776#ent", "pos": [13, 14]}}
{"token": ["C0967449#ent", "<e1>", "(", "also", "known", "as", "1229U91", "and", "C0537162#ent", "<e2>", ")", ",", "a", "purported", "Y(1", ")", "antagonist", "and", "Y(4", ")", "agonist", "was", "radiolabelled", "using", "the", "chloramine", "T", "method"], "h": {"id": "C0967449", "name": "C0967449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0537162", "name": "C0537162#ent", "pos": [8, 9]}}
{"token": ["Most", "cases", "with", "t(1;19)", "been", "identified", "to", "have", "rearranged", "band", "of", "C1336596#ent", "<e1>", "by", "Southern", "blotting", "analysis", "and", "to", "contain", "identical", "C1867800#ent", "<e2>", "chimeric", "transcripts", "by", "use", "of", "polymerase", "chain", "reaction", "assay"], "h": {"id": "C1336596", "name": "C1336596#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1867800", "name": "C1867800#ent", "pos": [21, 22]}}
{"token": ["1;19", "translocation", "can", "alter", "the", "C1336596#ent", "<e1>", "leading", "to", "formation", "of", "a", "chimeric", "C1867800#ent", "<e2>", "retain", "the", "activator", "domain", "of", "the", "C1336596#ent", "<e1>", "substitute", "a", "homeobox", "domain", "the", "PBX1", "gene", "the", "helix-loop-helix", "DNA", "binding", "dimerization", "domain", "E2A", "."], "h": {"id": "C1336596", "name": "C1336596#ent", "pos": [5, 6]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1867800", "name": "C1867800#ent", "pos": [13, 14]}}
{"token": ["Loss", "of", "5-HT", "transporter", "C1420214#ent", "<e1>", ")", "sites", "has", "been", "implicated", "in", "various", "C0751870#ent", "<e2>", "users", "of", "some", "amphetamine", "derivatives", "as", "MDMA", "."], "h": {"id": "C1420214", "name": "C1420214#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751870", "name": "C0751870#ent", "pos": [13, 14]}}
{"token": ["CYP2C19", "is", "a", "polymorphically", "expressed", "cytochrome", "P450", "for", "the", "metabolism", "of", "several", "clinically", "used", "drugs", ",", "including", "some", "barbiturates", ",", "diazepam", ",", "proguanil", ",", "C0033497#ent", "<e1>", "and", "several", "C0358591#ent", "<e2>"], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0358591", "name": "C0358591#ent", "pos": [28, 29]}}
{"token": ["Proteolysis", "maps", "of", "C1538319#ent", "<e1>", "the", "two", "subunits", "of", "C1418440#ent", "<e2>", "different", ",", "suggesting", "that", "all", "subunits", "are", "different", "entities", "."], "h": {"id": "C1538319", "name": "C1538319#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418440", "name": "C1418440#ent", "pos": [9, 10]}}
{"token": ["Case", "studies", "discussions", "are", "provided", "in", "this", "article", "to", "update", "physicians", "on", "the", "diagnosis", "and", "management", "of", "potentially", "unfamiliar", "ailments", ",", "including", "strongyloidiasis", ",", "C0019911#ent", "<e1>", "cysticercosis", ",", "clonorchiasis", "and", "C0030305#ent", "<e2>"], "h": {"id": "C0019911", "name": "C0019911#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0030305", "name": "C0030305#ent", "pos": [30, 31]}}
{"token": ["Among", "others", ",", "C0404484#ent", "<e1>", "CPPS", ")", ",", "enuresis", ",", "C0015732#ent", "<e2>", ",", "and", "sexual", "dysfunction", "occur", "."], "h": {"id": "C0404484", "name": "C0404484#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015732", "name": "C0015732#ent", "pos": [10, 11]}}
{"token": ["The", "C0669472#ent", "<e1>", "UBP", ")", "are", "a", "family", "of", "C3540790#ent", "<e2>", "that", "cleave", "ubiquitin", "from", "ubiquitinated", "protein", "."], "h": {"id": "C0669472", "name": "C0669472#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [9, 10]}}
{"token": ["The", "results", "taken", "together", "suggest", "that", "myristoylation", "of", "the", "C3853644#ent", "<e1>", "be", "very", "important", "for", "tumorigenicity", "of", "C0080298#ent", "<e2>", "cells", "."], "h": {"id": "C3853644", "name": "C3853644#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [17, 18]}}
{"token": ["Analysis", "of", "42", "human", "arterial", "sections", "immunohistochemistry", "and", "double", "label", "fluorescence", "microscopy", "that", "C1456795#ent", "<e1>", "and", "apoA-I", ",", "apoB", ",", "apoC-II", ",", "and", "C1412481#ent", "<e2>", "were", "increased", "significantly", "in", "atherosclerotic", "lesions", "with", "nonatherosclerotic", "segments", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [23, 24]}}
{"token": ["C0040259#ent", "<e1>", "interdigitalis", "may", "present", "as", "asymptomatic", "C0040247#ent", "<e2>", "dermatophytosis", "complex", ",", "which", "is", "symptomatic", ",", "with", "secondary", "bacterial", "infection"], "h": {"id": "C0040259", "name": "C0040259#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0040247", "name": "C0040247#ent", "pos": [7, 8]}}
{"token": ["Downregulation", "of", "C0669372#ent", "<e1>", "and", "NO", "is", "a", "pathway", "common", "for", "flavones", "and", "C0071649#ent", "<e2>", ",", "two", "distinct", "families", "of", "phytoalexins", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0071649", "name": "C0071649#ent", "pos": [13, 14]}}
{"token": ["In", "vitro", "studies", "were", "conducted", "to", "identify", "the", "hepatic", "cytochrome", "P450", "isoform", "involved", "in", "the", "metabolism", "of", "C0538555#ent", "<e1>", ",", "(", "(S)-2-[[(fluoro-4-indanyl)oxy]methyl]morpholine", "monohydrochloride", ")", ",", "a", "novel", "C0162758#ent", "<e2>", "in", "human", "liver", "microsomes", "."], "h": {"id": "C0538555", "name": "C0538555#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0162758", "name": "C0162758#ent", "pos": [27, 28]}}
{"token": ["The", "clinical", "picture", "general", "management", "C0878544#ent", "<e1>", "not", "differ", "substantially", "from", "those", "of", "C0007193#ent", "<e2>", "any", "type", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0007193", "name": "C0007193#ent", "pos": [13, 14]}}
{"token": ["The", "first", "episode", "occurred", "when", "C0456386#ent", "<e1>", "was", "shifted", "from", "bupropion", "to", "C0245561#ent", "<e2>", "abruptly", "."], "h": {"id": "C0456386", "name": "C0456386#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0245561", "name": "C0245561#ent", "pos": [12, 13]}}
{"token": ["Serum", "specimens", "79", "of", "87", "(", "91", "%", ")", "C0020102#ent", "<e1>", "patients", "reacted", "with", "the", "synthetic", "peptide", "Gag-1a", "(", "C3539947#ent", "<e2>", "a.a", ".", "]"], "h": {"id": "C0020102", "name": "C0020102#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [19, 20]}}
{"token": ["These", "data", "suggest", "that", "differential", "processing", "of", "the", "primary", "transcript", "the", "C1414833#ent", "<e1>", "mRNA", "in", "human", "brain", "and", "C0023899#ent", "<e2>", "could", "generate", "two", "mature", "mRNAs", "of", "1.4", "and", "1.1", "kb", "."], "h": {"id": "C1414833", "name": "C1414833#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [18, 19]}}
{"token": ["Sequence", "analysis", "suggests", "a", "differential", "poly(A)", "selection", "in", "the", "production", "of", "C1414833#ent", "<e1>", "mRNA", "in", "FB", "and", "C0023899#ent", "<e2>", "."], "h": {"id": "C1414833", "name": "C1414833#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [17, 18]}}
{"token": ["The", "new", "drug", "proved", "to", "be", "remarkably", "effective", "in", "symptoms", "as", "anxiety", ",", "restlessness", ",", "irritations", ",", "C0033893#ent", "<e1>", "well", "as", "functional", "cardiovascular", "diseases", "C0017178#ent", "<e2>"], "h": {"id": "C0033893", "name": "C0033893#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [24, 25]}}
{"token": ["This", "study", "demonstrates", "that", "in", "most", "patients", "with", "type", "5", "HLP", "there", "is", "a", "dual", "defect", "TG", "metabolism", "--", "C0001622#ent", "<e1>", "of", "VLDL", "C1537574#ent", "<e2>", "and", "a", "clearance", "defect", "for", "TG-rich", "lipoproteins", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1537574", "name": "C1537574#ent", "pos": [23, 24]}}
{"token": ["Tunicamycin", "was", "used", "for", "the", "synthesis", "of", "unglycosylated", "(glyco)proteins", ",", "the", "mannosidase", "I", "C0089267#ent", "<e1>", "for", "the", "synthesis", "of", "high-mannose", "type", "and", "the", "C0284655#ent", "<e2>", "swainsonine", "for", "the", "synthesis", "of", "hybrid-type", "glycoproteins", "."], "h": {"id": "C0089267", "name": "C0089267#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0284655", "name": "C0284655#ent", "pos": [23, 24]}}
{"token": ["In", "a", "postoperative", "patient", "with", "pre-existent", "myasthenia", "gravis", "oral", "C0042523#ent", "<e1>", "caused", "a", "marked", "exacerbation", "in", "C0947912#ent", "<e2>"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0947912", "name": "C0947912#ent", "pos": [16, 17]}}
{"token": ["We", "present", "C1414649#ent", "<e1>", "mRNA", "and", "C1414649#ent", "<e1>", "levels", "and", "the", "presence", "of", "intranuclear", "inclusions", "at", "different", "repeat", "lengths", "."], "h": {"id": "C1414649", "name": "C1414649#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414649", "name": "C1414649#ent", "pos": [2, 3]}}
{"token": ["Our", "previous", "results", "demonstrated", "that", "OSM", "is", "a", "scaffold", "for", "the", "assembly", "of", "the", "GTPase", "Rac", "the", "C0528266#ent", "<e1>", "for", "the", "hyperosmotic", "stress-dependent", "activation", "of", "C1456380#ent", "<e2>"], "h": {"id": "C0528266", "name": "C0528266#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1456380", "name": "C1456380#ent", "pos": [25, 26]}}
{"token": ["A", "right", "ventricular", "endomyocardial", "biopsy", "from", "a", "30-year-old", "male", "with", "C1579397#ent", "<e1>", "progressive", "external", "ophthalmoplegia", ",", "retinal", "pigmentation", "and", "complete", "C0151517#ent", "<e2>", "Kearns-Sayre", "syndrome", "was", "examined", "in", "the", "electron", "microscope"], "h": {"id": "C1579397", "name": "C1579397#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151517", "name": "C0151517#ent", "pos": [20, 21]}}
{"token": ["Receptors", "decrease", "found", "in", "these", "regions", "might", "be", "associated", "with", "chronic", "inactivation", "C1416273#ent", "<e1>", "DA", "neurons", ",", "to", "which", "the", "antipsychotic", "effect", "the", "C0013227#ent", "<e2>", "is", "attributed", "."], "h": {"id": "C1416273", "name": "C1416273#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [23, 24]}}
{"token": ["Newly", "developed", ",", "simple", ",", "low-cost", "and", "sensitive", "ion-selective", "electrodes", "been", "proposed", "for", "determination", "of", "some", "antiepileptic", "drugs", "as", "lamotrigine", ",", "felbamate", ",", "and", "C0033148#ent", "<e1>", "in", "their", "C0013227#ent", "<e2>", "well", "as", "in", "biological", "fluids"], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [28, 29]}}
{"token": ["A", "patient", "who", "is", "intellectually", "and", "emotionally", "intact", "with", "no", "past", "history", "of", "behavioral", "disturbances", "may", "do", "better", "on", "C0033148#ent", "<e1>", "than", "carbamazepine", ",", "because", "this", "C0013227#ent", "<e2>", "gives", "fewer", "side", "effects"], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [26, 27]}}
{"token": ["Addition", "of", "C0076281#ent", "<e1>", "does", "not", "significantly", "change", "the", "iron", "coordination", "the", "Fe(II", ")", "C0027203#ent", "<e2>", "."], "h": {"id": "C0076281", "name": "C0076281#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}}
{"token": ["Factor", "VIIa", "which", "also", "possesses", "C1335808#ent", "<e1>", ",", "bound", "soluble", "C3889715#ent", "<e2>", "with", "similar", "affinity", "to", "wild-type", "protein", "C", ",", "collectively", "confirming", "C1335808#ent", "<e1>", "as", "the", "critical", "residue", "for", "C3889715#ent", "<e2>", "recognition", "."], "h": {"id": "C1335808", "name": "C1335808#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889715", "name": "C3889715#ent", "pos": [10, 11]}}
{"token": ["An", "important", "aspect", "of", "the", "function", "of", "the", "C1824740#ent", "<e1>", "been", "suggested", "to", "be", "to", "trap", "and", "retain", "selected", "C0021699#ent", "<e2>", "points", "on", "the", "cell", "surface", "by", "cell", "adhesion", "molecules"], "h": {"id": "C1824740", "name": "C1824740#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [19, 20]}}
{"token": ["We", "performed", "flow", "cytometry", "lymphocyte", "subtypes", "and", "for", "activation", "markers", "HLA-DR", ",", "C1705979#ent", "<e1>", ",", "and", "CD69", "or", "C1420708#ent", "<e2>", ")", "."], "h": {"id": "C1705979", "name": "C1705979#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [18, 19]}}
{"token": ["Comparisons", "between", "the", "development", "of", "embryos", "revealed", "significant", "differences", "between", "normo-", "and", "C0403823#ent", "<e1>", "men", "versus", "C0028960#ent", "<e2>", "patients", "."], "h": {"id": "C0403823", "name": "C0403823#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0028960", "name": "C0028960#ent", "pos": [16, 17]}}
{"token": ["Six", "types", "of", "corneal", "pathologic", "lesions", "treated", ":", "recurrent", "corneal", "erosions", "corneal", "scars", "C0019357#ent", "<e1>", "anterior", "stromal", "dystrophy", "band", "keratopathy", "mucous", "plaque", "and", "scar", "after", "C0042769#ent", "<e2>"], "h": {"id": "C0019357", "name": "C0019357#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [25, 26]}}
{"token": ["Finally", ",", "responses", "were", "attenuated", "by", "inhibitors", "of", "protein", "kinase", "C", "C1826724#ent", "<e1>", ")", "but", "not", "by", "inhibitors", "of", "C0001492#ent", "<e2>"], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [19, 20]}}
{"token": ["At", "higher", "concentrations", "the", "C0304402#ent", "<e1>", "activity", "of", "C0062124#ent", "<e2>", "(", "10(-5)-10(-4", ")", "M", ")", "counteracts", "its", "GABA-potentiating", "effects", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0062124", "name": "C0062124#ent", "pos": [8, 9]}}
{"token": ["We", "have", "examined", "cyclic", "AMP", "responses", "to", "isoprenaline", ",", "histamine", ",", "and", "prostaglandin", "E2", "peripheral", "blood", "mononuclear", "leukocytes", "from", "patients", "with", "C1419789#ent", "<e1>", ",", "in", "the", "presence", "and", "absence", "of", "a", "potent", "C1318700#ent", "<e2>"], "h": {"id": "C1419789", "name": "C1419789#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1318700", "name": "C1318700#ent", "pos": [32, 33]}}
{"token": ["Left", "ventricular", "free", "wall", "thickness", "increased", "4", "weeks", "after", "production", "of", "C0003504#ent", "<e1>", "and", "plasma", "C3887648#ent", "<e2>", "increased", "1", "day", "after", "the", "procedure", "."], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [15, 16]}}
{"token": ["The", "enzyme-linked", "immunosorbent", "assay", "serum", "human", "C0669372#ent", "<e1>", "C0812325#ent", "<e2>", "prove", "useful", "for", "serum", "human", "C0669372#ent", "<e1>", "C0812325#ent", "<e2>", "measurement", "in", "patients", "with", "various", "liver", "diseases"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [8, 9]}}
{"token": ["While", "C3887694#ent", "<e1>", "induces", "a", "number", "of", "strong", "tyrosine", "phosphorylations", "including", "C0597721#ent", "<e2>", "Jak", ")", "and", "the", "signal", "transducer", "activator", "of", "transcription", "Stat", ")", "proteins", ",", "LIF", "induces", "only", "minor", "tyrosine", "phosphorylation", "Tyk2", "and", "Stat3", "."], "h": {"id": "C3887694", "name": "C3887694#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0597721", "name": "C0597721#ent", "pos": [11, 12]}}
{"token": ["We", "reported", "previously", "that", "patients", "with", "C0023896#ent", "<e1>", "ALD", ")", "have", "circulating", "immunoglobulins", "reacting", "with", "C0010763#ent", "<e2>", "CYP2E1", ")", "complexed", "with", "hydroxyethyl", "free", "radicals"], "h": {"id": "C0023896", "name": "C0023896#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [15, 16]}}
{"token": ["Moreover", ",", "the", "integrity", "of", "the", "epithelial", "barrier", "preserved", "because", "DCs", "express", "C1420744#ent", "<e1>", "such", "as", "occludin", ",", "claudin", "1", "Junctional", "Adhesion", "Molecule", "C3890557#ent", "<e2>", ")", "and", "can", "establish", "tight", "junctions-like", "structures", "with", "neighbouring", "epithelial", "cells"], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3890557", "name": "C3890557#ent", "pos": [23, 24]}}
{"token": ["AF-6", "as", "well", "as", "C1420744#ent", "<e1>", "could", "be", "coprecipitated", "with", "C3890557#ent", "<e2>", "from", "endothelial", "cell", "extracts", "demonstrating", "the", "association", "of", "the", "endogenously", "expressed", "molecules", "in", "vivo"], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890557", "name": "C3890557#ent", "pos": [10, 11]}}
{"token": ["After", "four", "months", "of", "excessive", "nitrous", "oxide", "N2O", ")", "exposure", ",", "a", "dentist", "had", "C0162309#ent", "<e1>", "with", "spastic", "paraparesis", "Lhermitte's", "sign", "sensory", "shading", ",", "loss", "of", "position", "vibration", "sense", "C0004134#ent", "<e2>", ",", "and", "impotence", "."], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [29, 30]}}
{"token": ["In", "addition", ",", "we", "studied", "whether", "risk", "of", "IBD", "is", "associated", "with", "functional", "variants", "of", "two", "C1332838#ent", "<e1>", "the", "chemokine", "receptor", "CCR5", "gene", "chromosome", "3p21", "the", "interleukin-4", "receptor", "alpha-subunit", "gene", "C1705220#ent", "<e2>", ")", "on", "chromosome", "16"], "h": {"id": "C1332838", "name": "C1332838#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705220", "name": "C1705220#ent", "pos": [30, 31]}}
{"token": ["Here", "we", "identify", "the", "CPH", "domains", "(", "conserved", "domain", "within", "Cul7", ",", "PARC", ",", "and", "C1415512#ent", "<e1>", "of", "both", "Cul7", "and", "PARC", "as", "C1705526#ent", "<e2>", "interaction", "domains", "using", "size", "exclusion", "chromatography", "NMR", "spectroscopy"], "h": {"id": "C1415512", "name": "C1415512#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [23, 24]}}
{"token": ["The", "usual", "symptoms", "of", "acute", "mountain", "sickness", "headache", ",", "nausea", ",", "vomiting", ",", "C1950154#ent", "<e1>", ",", "lassitude", ",", "dizziness", "and", "C0004134#ent", "<e2>", "."], "h": {"id": "C1950154", "name": "C1950154#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [20, 21]}}
{"token": ["We", "have", "previously", "documented", "that", "prostate-specific", "antigen", "PSA", ")", ",", "a", "C2717971#ent", "<e1>", "the", "kallikrein", "family", ",", "is", "an", "C0123707#ent", "<e2>"], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0123707", "name": "C0123707#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "C0001477#ent", "<e1>", "Ca2", "+", "entry", "through", "C1425225#ent", "<e2>", "is", "enhanced", "three-", "to", "fourfold", "by", "2-APB", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1425225", "name": "C1425225#ent", "pos": [8, 9]}}
{"token": ["Combined", "therapy", "PUVASOL", "and", "C0358518#ent", "<e1>", "dispropionate", "0.05", "%", "with", "C0036079#ent", "<e2>", "application", "appears", "to", "be", "safe", "and", "an", "effective", "treatment", "for", "scalp", "psoriasis"], "h": {"id": "C0358518", "name": "C0358518#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036079", "name": "C0036079#ent", "pos": [10, 11]}}
{"token": ["Others", "have", "focused", "on", "trying", "to", "capture", "other", "important", "neurochemical", "events", ",", "such", "as", "excitotoxicity", ",", "cell", "membrane", "degradation", "reactive", "oxygen", "species", "C0812281#ent", "<e1>", ")", "and", "nitric", "oxide", "NO", ")", "formation", ",", "C0013604#ent", "<e2>", "and", "BBB", "dysfunction"], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [32, 33]}}
{"token": ["Based", "on", "our", "6-month", "evaluation", ",", "C0050559#ent", "<e1>", "does", "not", "produce", "a", "consistent", "toxic", "effect", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C0050559", "name": "C0050559#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["This", "is", "the", "first", "reported", "case", "of", "C0153225#ent", "<e1>", "in", "a", "patient", "with", "a", "C0272242#ent", "<e2>"], "h": {"id": "C0153225", "name": "C0153225#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0272242", "name": "C0272242#ent", "pos": [14, 15]}}
{"token": ["Of", "the", "three", "major", "C0031727#ent", "<e1>", "that", "phosphorylated", "the", "SP2", "peptide", "C0915195#ent", "<e2>", "(", "partially", "Ca2", "+", "sensitive", ")", "and", "PKIII", "(", "Ca2", "+", "insensitive", ")", "inactivated", "native", "spinach", "leaf", "SPS", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0915195", "name": "C0915195#ent", "pos": [11, 12]}}
{"token": ["Possession", "of", "the", "antigen", "HLA", "B27", "severity", "and", "prognosis", "of", "the", "C0003864#ent", "<e1>", "and", "is", "more", "often", "associated", "with", "C0038012#ent", "<e2>", "and", "Reiter's", "syndrome"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0038012", "name": "C0038012#ent", "pos": [19, 20]}}
{"token": ["One", "year", "after", "start", "of", "interferon", "(", "C1415900#ent", "<e1>", ")", "treatment", ",", "only", "one", "patient", "developed", "C0030517#ent", "<e2>"], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030517", "name": "C0030517#ent", "pos": [16, 17]}}
{"token": ["Taken", "together", ",", "these", "results", "suggest", "that", "NCI-H345", "cells", "express", "C0072522#ent", "<e1>", "P-selectin", "that", "are", "distinct", "from", "leukocyte", "C1419941#ent", "<e2>", "."], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419941", "name": "C1419941#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "ESL(lo", ")", "MDA", "cells", "did", "not", "display", "sLe(X", ")", "on", "C0072522#ent", "<e1>", "capable", "of", "bearing", "sLe(X", ")", ",", "notably", "C1419941#ent", "<e2>"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419941", "name": "C1419941#ent", "pos": [21, 22]}}
{"token": ["The", "latter", "response", "was", "also", "insensitive", "to", "the", "phospholipase", "C", "inhibitor", "U-73122", ",", "the", "protein", "kinase", "inhibitor", "C0075193#ent", "<e1>", "and", "to", "the", "inhibitors", "of", "arachidonic", "acid", "indomethacin", "and", "C0733397#ent", "<e2>"], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0733397", "name": "C0733397#ent", "pos": [28, 29]}}
{"token": ["In", "hepatoma", "Hep3B", "cells", ",", "IL-6", "induces", "C1413766#ent", "<e1>", "expression", "by", "activating", "transcription", "factors", "C1367307#ent", "<e2>", "and", "C/EBPbeta", "."], "h": {"id": "C1413766", "name": "C1413766#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [14, 15]}}
{"token": ["These", "results", "support", "common", "use", "of", "stem", "bark", "C1313497#ent", "<e1>", "and", "conessine", "isolated", "from", "C1313497#ent", "<e1>", "in", "the", "treatment", "of", "some", "C0005943#ent", "<e1>"], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005943", "name": "C0005943#ent", "pos": [21, 22]}}
{"token": ["Mitogenic", "effect", "HB-EGF", "was", "as", "potent", "as", "that", "of", "other", "known", "C0026249#ent", "<e1>", "for", "gastric", "epithelial", "cells", "such", "as", "hepatocyte", "growth", "factor", "C1524023#ent", "<e2>", ")", "and", "transforming", "growth", "factor", "(TGF)-alpha"], "h": {"id": "C0026249", "name": "C0026249#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1524023", "name": "C1524023#ent", "pos": [22, 23]}}
{"token": ["C0054040#ent", "<e1>", "kinetics", "were", "examined", "in", "patients", "with", "varying", "degrees", "of", "C1565662#ent", "<e2>", "a", "single", "intravenous", "dose", "bretylium", "tosylate"], "h": {"id": "C0054040", "name": "C0054040#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1565662", "name": "C1565662#ent", "pos": [11, 12]}}
{"token": ["Transposition", "of", "the", "extraocular", "muscles", "an", "effective", "treatment", "for", "C0152221#ent", "<e1>", "was", "reexamined", "and", "a", "new", "surgical", "procedure", "developed", "for", "C0271355#ent", "<e2>"], "h": {"id": "C0152221", "name": "C0152221#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0271355", "name": "C0271355#ent", "pos": [20, 21]}}
{"token": ["The", "diagnosis", "of", "Lyme", "borreliosis", "made", "according", "to", "following", "data", ":", "origin", "from", "an", "area", "endemic", "for", "Lyme", "borreliosis", "tick", "bite", "C0017677#ent", "<e1>", "significant", "levels", "of", "the", "antibodies", "to", "the", "Borrelia", "burgdorferi", "C3892044#ent", "<e2>", "."], "h": {"id": "C0017677", "name": "C0017677#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3892044", "name": "C3892044#ent", "pos": [32, 33]}}
{"token": ["Bile", "salts", "potent", "inhibitors", "of", "C0007034#ent", "<e1>", "human", "carbonic", "anhydrase", "I", "human", "C0007034#ent", "<e1>"], "h": {"id": "C0007034", "name": "C0007034#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007034", "name": "C0007034#ent", "pos": [5, 6]}}
{"token": ["Electron", "microscopy", "performed", "in", "5", "patients", "(", "4", "considered", "to", "have", "C1424700#ent", "<e1>", ",", "and", "1", "with", "C0264511#ent", "<e2>", "and", "in", "all", "cases", "showed", "whorled", "myelin", "figures", "characteristic", "of", "surfactant", "."], "h": {"id": "C1424700", "name": "C1424700#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0264511", "name": "C0264511#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "we", "show", "that", "this", "C0729218#ent", "<e1>", "like", "cyclophilin", ",", "has", "C1422813#ent", "<e2>", "activity", "."], "h": {"id": "C0729218", "name": "C0729218#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422813", "name": "C1422813#ent", "pos": [13, 14]}}
{"token": ["Accompanying", "changes", "in", "2", "synaptic", "vesicle-associated", "proteins", "synapsin", "I", "C1366876#ent", "<e1>", ",", "and", "the", "astrocyte-associated", "protein", "glial", "fibrillary", "acidic", "protein", "C1415042#ent", "<e2>", ")", ",", "were", "measured", "by", "radioimmunoassay", "(", "RIA", ")", "."], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415042", "name": "C1415042#ent", "pos": [20, 21]}}
{"token": ["Our", "results", "point", "out", "that", "BAI2", "controls", "VEGF", "transcription", "through", "C1366439#ent", "<e1>", "under", "normal", "conditions", "and", "C0007785#ent", "<e2>"], "h": {"id": "C1366439", "name": "C1366439#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [16, 17]}}
{"token": ["Differential", "diagnoses", "bullous", "impetigo", "C0549208#ent", "<e1>", "immunobullous", "disease", "neonatal", "lupus", "and", "C0857751#ent", "<e2>"], "h": {"id": "C0549208", "name": "C0549208#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0857751", "name": "C0857751#ent", "pos": [11, 12]}}
{"token": ["The", "extent", "of", "angiogenesis", "and/or", "C1522575#ent", "<e1>", "VEGF", ")", "expression", "in", "neuroblastoma", "tumors", "correlates", "with", "metastases", ",", "C0812287#ent", "<e2>", "amplification", ",", "and", "poor", "clinical", "outcome"], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812287", "name": "C0812287#ent", "pos": [17, 18]}}
{"token": ["The", "authors", "report", "irritable", "mood", "anxiety", ",", "sleeplessness", ",", "C0270697#ent", "<e1>", ",", "and", "generalized", "aches", "pains", "associated", "with", "abrupt", "discontinuation", "of", "C0085208#ent", "<e2>", "treatment", "in", "a", "32-year-old", "man", "being", "treated", "for", "nicotine", "dependence", "."], "h": {"id": "C0270697", "name": "C0270697#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085208", "name": "C0085208#ent", "pos": [21, 22]}}
{"token": ["Plasma", "retinoid", "levels", "were", "evaluated", "by", "reverse-phase", "HPLC", "and", "confirmed", "that", "blood-level", "concentrations", "of", "13-cis", "C0003873#ent", "<e1>", "and", "metabolites", "in", "these", "C0001144#ent", "<e2>", "patients", "reached", "values", "previously", "demonstrated", "to", "be", "immunomodulatory", "in", "vitro"], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001144", "name": "C0001144#ent", "pos": [21, 22]}}
{"token": ["C0752501#ent", "<e1>", "is", "thus", "required", "for", "promoting", "C1706006#ent", "<e2>", "expression", "and", "for", "potentiating", "Fas-mediated", "apoptosis", "."], "h": {"id": "C0752501", "name": "C0752501#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706006", "name": "C1706006#ent", "pos": [7, 8]}}
{"token": ["A", "consanguineous", "Israeli", "Bedouin", "kindred", "presented", "with", "an", "C3899988#ent", "<e1>", "nonlethal", "phenotype", "of", "severe", "psychomotor", "retardation", "extrapyramidal", "signs", "dystonia", ",", "C0004158#ent", "<e2>", "and", "ataxia", ",", "mild", "axial", "hypotonia", "and", "marked", "global", "dementia", "defects", "in", "verbal", "and", "expressive", "communication", "skills"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004158", "name": "C0004158#ent", "pos": [20, 21]}}
{"token": ["Both", "ampC3", "and", "C3538714#ent", "<e1>", "showed", "transformation", "linkage", "to", "C1424884#ent", "<e2>", "and", "str", "."], "h": {"id": "C3538714", "name": "C3538714#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1424884", "name": "C1424884#ent", "pos": [9, 10]}}
{"token": ["Using", "immunoblotting", "techniques", "the", "Kv3.2", "protein", "was", "weakly", "detected", "at", "postnatal", "age", "7", "(", "C1424742#ent", "<e1>", ")", ",", "and", "full", "expression", "was", "attained", "at", "C0079471#ent", "<e2>", "in", "tissue", "extracts", "homogenized", "hippocampal", "preparations", "."], "h": {"id": "C1424742", "name": "C1424742#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [24, 25]}}
{"token": ["These", "effects", "were", "attenuated", "by", "EGFR", "tyrosine", "kinase", "inhibitor", "PD153035", "or", "an", "anti-EGFR", "monoclonal", "antibody", "whereas", "protein", "kinase", "C", "inhibitors", "H7", "and", "bisindolylmaleimide", "I", "mitogen-activated", "protein", "kinase/extracellular", "signal-regulated", "kinase", "kinase", "inhibitor", "C0298346#ent", "<e1>", "abolished", "profilaggrin", "up-regulation", "but", "not", "C3810565#ent", "<e2>", "suppression", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [31, 32]}, "relation": "NA", "t": {"id": "C3810565", "name": "C3810565#ent", "pos": [38, 39]}}
{"token": ["These", "observations", "indicate", "that", "abnormal", "regulation", "of", "C3537249#ent", "<e1>", "metabolism", "in", "C0733682#ent", "<e2>", "in", "the", "proximal", "convoluted", "tubule", "results", ",", "not", "from", "aberrant", "transcriptional", "regulation", "but", "from", "a", "defect", "in", "translational", "or", "post-translational", "activity"], "h": {"id": "C3537249", "name": "C3537249#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0733682", "name": "C0733682#ent", "pos": [11, 12]}}
{"token": ["The", "C3538730#ent", "<e1>", "encoded", "a", "protein", "of", "1,313", "amino", "acids", "carried", "a", "C3539812#ent", "<e2>", "the", "C-terminal", "region", "was", "apparently", "conserved", "among", "eukaryotes", "."], "h": {"id": "C3538730", "name": "C3538730#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3539812", "name": "C3539812#ent", "pos": [12, 13]}}
{"token": ["TGF-betas", "have", "been", "reported", "to", "mediate", "the", "repression", "by", "C2757070#ent", "<e1>", "of", "several", "C0127082#ent", "<e2>", "the", "human", "endometrium", ",", "thereby", "preventing", "menstrual", "breakdown", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0127082", "name": "C0127082#ent", "pos": [13, 14]}}
{"token": ["Posttranslational", "acetylation", "deacetylation", "of", "this", "subunit", "by", "an", "acetyltransferase", "called", "C1538918#ent", "<e1>", "(", "ARD1", ")", "and", "by", "different", "C1333891#ent", "<e2>", "HDACs", ")", ",", "respectively", ",", "has", "been", "suggested", "as", "a", "mechanism", "."], "h": {"id": "C1538918", "name": "C1538918#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [18, 19]}}
{"token": ["C0009088#ent", "<e1>", "a", "rare", "C0018681#ent", "<e2>", "entity", "that", "predominantly", "occurs", "in", "younger", "males", "."], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [4, 5]}}
{"token": ["The", "abnormal", "fibrin", "resulting", "from", "C0002823#ent", "<e1>", "either", "does", "not", "bind", "C1706331#ent", "<e2>", "in", "vivo", "does", "so", "reversibly", "."], "h": {"id": "C0002823", "name": "C0002823#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [11, 12]}}
{"token": ["Several", "reports", "of", "C0015674#ent", "<e1>", "showed", "the", "high", "rate", "sleep", "disturbance", "as", "insomnia", ",", "C0206085#ent", "<e2>", ",", "circadian", "rhythm", "sleep", "disorder", "sleep", "apnea/hypopnea", "syndrome", "so", "on", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0206085", "name": "C0206085#ent", "pos": [14, 15]}}
{"token": ["Our", "C3540471#ent", "<e1>", "was", "to", "compare", "the", "analgesic", "efficacy", "pamidronate", "(", "C1428063#ent", "<e2>", ")", "and", "synthetic", "human", "calcitonin", "(", "CT", ")", "in", "intravenous", "infusion", "recent", "painful", "benign", "vertebral", "compression", "a", "randomised", "prospective", "double-blind", "study"], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1428063", "name": "C1428063#ent", "pos": [11, 12]}}
{"token": ["Ten", "patients", "had", "symptoms", "related", "to", "C0836924#ent", "<e1>", ",", "eight", "at", "the", "time", "of", "starting", "C0051809#ent", "<e2>", "treatment", "."], "h": {"id": "C0836924", "name": "C0836924#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0051809", "name": "C0051809#ent", "pos": [15, 16]}}
{"token": ["Computer-assisted", "analysis", "LIYV", "RNA", "1", "C0341703#ent", "<e1>", "identified", "domains", "for", "a", "C0006784#ent", "<e2>", "methyltransferase", "(", "MTR", ")", ",", "RNA", "helicase", "HEL", ")", ",", "and", "RNA-dependent", "RNA", "polymerase", "RdRp", ")", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [11, 12]}}
{"token": ["This", "effect", "was", "most", "notable", "for", "xR2DLV", ",", "which", "possessed", "a", "binding", "affinity", "for", "C0535906#ent", "<e1>", "approximately", "15-fold", "greater", "for", "C0535906#ent", "<e1>", "than", "C0074087#ent", "<e1>", "."], "h": {"id": "C0535906", "name": "C0535906#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0074087", "name": "C0074087#ent", "pos": [23, 24]}}
{"token": ["The", "C1413769#ent", "<e1>", "showed", "higher", "activity", "but", "the", "C3887634#ent", "<e2>", "promoter", "showed", "lower", "activity", "in", "TLP-null", "cells", "than", "in", "the", "wild-type", "cells", "."], "h": {"id": "C1413769", "name": "C1413769#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3887634", "name": "C3887634#ent", "pos": [8, 9]}}
{"token": ["Toxic", "mussels", "held", "in", "tanks", "and", "C0600142#ent", "<e1>", "with", "uncontaminated", "sea", "water", "a", "decline", "in", "C0058678#ent", "<e2>", "concentration", "in", "mussel", "tissue", "time", "."], "h": {"id": "C0600142", "name": "C0600142#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0058678", "name": "C0058678#ent", "pos": [15, 16]}}
{"token": ["Elevated", "blood", "levels", "the", "proinflammatory", "cytokines", "interleukin-6", "(", "IL-6", ")", ",", "interleukin-8", "(", "IL-8", ")", ",", "and", "C1705079#ent", "<e1>", "(", "monocyte", "chemoattractant", "protein-1", "increase", "insulin", "resistance", "the", "risk", "of", "C0007222#ent", "<e2>", "CVD", ")", "."], "h": {"id": "C1705079", "name": "C1705079#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [29, 30]}}
{"token": ["C0001486#ent", "<e1>", "found", "more", "often", "than", "all", "the", "other", "C0042769#ent", "<e2>", "(", "if", "influenza", "was", "excluded", ")", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}}
{"token": ["The", "actin", "superfamily", "ATPases", "includes", "cytoskeletal", "actins", "the", "stress", "70", "proteins", "e.g.", "C1415764#ent", "<e1>", ")", ",", "sugar", "kinases", ",", "C0017868#ent", "<e2>", "and", "several", "prokaryotic", "cell", "cycle", "proteins"], "h": {"id": "C1415764", "name": "C1415764#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [19, 20]}}
{"token": ["C0751434#ent", "<e1>", "(", "PKU", ",", "MIM", "261600", ";", "C4285344#ent", "<e2>", "results", "from", "mutations", "in", "the", "phenylalanine", "hydroxylase", "PAH", ")", "gene", "."], "h": {"id": "C0751434", "name": "C0751434#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4285344", "name": "C4285344#ent", "pos": [8, 9]}}
{"token": ["This", "study", "compares", "the", "cardiovascular", "and", "C0003195#ent", "<e1>", "sparteine", "and", "a", "3,7-diheterobicyclo[3.3.1]nonane", "analogue", "of", "sparteine", ",", "C0107136#ent", "<e2>", ",", "in", "pentobarbitone-anaesthetized", "rats", "subjected", "to", "left-ventricle", "electrical", "stimulation", "and", "occlusion", "of", "the", "left", "anterior", "descending", "coronary", "artery"], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0107136", "name": "C0107136#ent", "pos": [16, 17]}}
{"token": ["Inhibitory", "effects", "myocardial", "Na+,K(+)-ATPase", "and", "Mg(2+)-activated", "ATPase", "activities", "may", "be", "the", "basis", "of", "some", "electrophysiological", "effects", "C0003195#ent", "<e1>", "properties", "of", "C0107136#ent", "<e2>", ",", "SAZ-VII-22", ",", "SAZ-VII-23", ",", "and", "tedisamil", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0107136", "name": "C0107136#ent", "pos": [20, 21]}}
{"token": ["Atrial", "natriuretic", "peptide", "C1417807#ent", "<e1>", ")", "is", "rapidly", "degraded", "by", "C1442934#ent", "<e2>", "EC", "3.4.24.11", "NEP", ")", ",", "with", "the", "kidney", "being", "a", "major", "site", "of", "C1417807#ent", "<e1>", "clearance", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1442934", "name": "C1442934#ent", "pos": [10, 11]}}
{"token": ["Binding", "to", "these", "sites", "was", "rapid", ",", "and", "relatively", "independent", "of", "temperature", "between", "37", "and", "0degreeC.", "C0042680#ent", "<e1>", "desacetylvinblastine", "sulfate", "two", "other", "active", "C0042672#ent", "<e2>", "competitively", "inhibited", "the", "binding", "of", "vinblastine", "."], "h": {"id": "C0042680", "name": "C0042680#ent", "pos": [16, 17]}, "relation": "has_structural_class", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [23, 24]}}
{"token": ["C1418947#ent", "<e1>", "mutations", "are", "usually", "associated", "with", "childhood", "onset", "GH", "and", "TSH", "C2713546#ent", "<e2>", ",", "whereas", "gonadotroph", "deficiency", "diagnosed", "at", "pubertal", "age", "."], "h": {"id": "C1418947", "name": "C1418947#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [12, 13]}}
{"token": ["Besides", ",", "repression", "of", "insulin", "signalling", "either", "PI-3K", "C0169101#ent", "<e1>", "inhibitor", "diminished", "expression", "of", "selected", "C0599220#ent", "<e2>", "of", "the", "mitochondrial", "oxidative", "phosphorylation", "enzymes", "OXPHOS", ")", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [15, 16]}}
{"token": ["The", "mechanism", "of", "C1332777#ent", "<e1>", "hypokalemia", "and", "its", "implications", "in", "C0027051#ent", "<e2>", "were", "discussed", "in", "detail", "."], "h": {"id": "C1332777", "name": "C1332777#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [10, 11]}}
{"token": ["B.", "dermatitidis", "incubated", "with", "BALF", "and", "washed", ",", "plus", "C1706320#ent", "<e1>", ",", "stimulated", "63", "%", "less", "production", "of", "C0812246#ent", "<e2>", "than", "did", "unwashed", "B.", "dermatitidis", "(", "P", "<", "0.05", ")", "."], "h": {"id": "C1706320", "name": "C1706320#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [18, 19]}}
{"token": ["In", "C0403396#ent", "<e1>", "patients", ",", "activation", "of", "NF-kappaB", ",", "C1333571#ent", "<e2>", ",", "p38", ",", "and", "JNK", "was", "mainly", "found", "in", "lamina", "propria", "macrophages", "."], "h": {"id": "C0403396", "name": "C0403396#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [9, 10]}}
{"token": ["Injection", "of", "secretin", "resulted", "in", "duodenal", "juice", "less", "C0041236#ent", "<e1>", "but", "more", "lipase", "activity", "that", "elicited", "by", "C0039659#ent", "<e2>"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039659", "name": "C0039659#ent", "pos": [17, 18]}}
{"token": ["We", "conclude", "that", "a", "mixed", "adrenergic", "C2987634#ent", "<e1>", "such", "as", "C0033798#ent", "<e2>", "more", "ideally", "corrects", "the", "noncardiac", "circulatory", "sequelae", "of", "spinal", "anesthesia", "does", "either", "a", "pure", "alpha-", "or", "beta-adrenergic", "agonist"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [10, 11]}}
{"token": ["Kelch", "domain", "BTB/POZ", "proteins", "like", "Mayven", "and", "C1427969#ent", "<e1>", "display", "limited", "sequence", "similarity", "the", "actin-fragmin", "kinase", "Physarum", ",", "a", "C0010536#ent", "<e2>", "a", "kelch", "domain"], "h": {"id": "C1427969", "name": "C1427969#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [19, 20]}}
{"token": ["Rett", "and", "C0162635#ent", "<e1>", "emerged", "slowly", "from", "their", "initial", "classifications", "as", "degenerative", "disorders", "C0019151#ent", "<e2>", "the", "terms", "development", "and", "developmental", "arrest", "been", "used", "for", "200", "years", "."], "h": {"id": "C0162635", "name": "C0162635#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [13, 14]}}
{"token": ["Neither", "C1623038#ent", "<e1>", "nor", "alcoholism", "altered", "the", "C4049614#ent", "<e2>", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4049614", "name": "C4049614#ent", "pos": [7, 8]}}
{"token": ["C0004259#ent", "<e1>", "induced", "a", "significant", "prolongation", "and", "C0024003#ent", "<e2>", "of", "the", "postexcitatory", "inhibitory", "phases", "water-deprived", "trained", "rats", ",", "to", "which", "light", "flashes", "as", "conditioned", "stimuli", "initiated", "a", "drinking", "behaviour"], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024003", "name": "C0024003#ent", "pos": [7, 8]}}
{"token": ["The", "most", "frequent", "problems", "justifying", "drug", "use", "classified", "as", ":", "Endocrine", ",", "nutritional", "and", "C0025517#ent", "<e1>", "immunity", "disorders", "Symptoms", ",", "signs", "and", "C0231218#ent", "<e2>", "defined", "conditions", ";", "Infectious", "and", "parasitic", "diseases"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [22, 23]}}
{"token": ["A", "confirmed", "causal", "relationship", "between", "drug", "and", "acute", "pancreatitis", "far", "exists", "only", "for", "8", "compounds", ":", "azathioprine", ",", "chlorothiazide", ",", "furosemide", ",", "C3539179#ent", "<e1>", ",", "tetracycline", ",", "estrogens", ",", "valproic", "acid", "C0003993#ent", "<e2>", "."], "h": {"id": "C3539179", "name": "C3539179#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0003993", "name": "C0003993#ent", "pos": [31, 32]}}
{"token": ["The", "effect", "of", "C0033497#ent", "<e1>", "on", "renal", "haemodynamics", "studied", "in", "nine", "patients", "with", "C0020538#ent", "<e2>", "moderate", "to", "severe", "chronic", "renal", "failure"], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [13, 14]}}
{"token": ["Thus", "molsidomine", "showed", "C3537168#ent", "<e1>", "and", "anti-ischemic", "efficacy", "in", "the", "treatment", "of", "stable", "C0002962#ent", "<e2>", "to", "the", "effect", "of", "long-term", "therapy", "with", "beta-adrenergic", "blockers"], "h": {"id": "C3537168", "name": "C3537168#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0002962", "name": "C0002962#ent", "pos": [13, 14]}}
{"token": ["The", "efficacy", "of", "each", "treatment", "was", "assessed", "by", "the", "percentage", "changes", "in", "C1538066#ent", "<e1>", "and", "C1705520#ent", "<e2>", "(", "%", "C1538066#ent", "<e1>", "and", "%", "C1705520#ent", "<e2>", ",", "respectively", ")", "."], "h": {"id": "C1538066", "name": "C1538066#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705520", "name": "C1705520#ent", "pos": [15, 16]}}
{"token": ["TNF", ",", "C1415900#ent", "<e1>", ",", "LT", "and", "C1522428#ent", "<e2>", "are", "well-known", "biological", "response", "modifiers", "BRM", ")", "with", "cytocidal", "activity", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [7, 8]}}
{"token": ["Rather", ",", "C1415900#ent", "<e1>", "augmented", "production", "of", "C1522428#ent", "<e2>", "and", "IL-2", "by", "PBL", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [7, 8]}}
{"token": ["The", "authors", "recently", "have", "shown", "that", "triplication", "of", "the", "C2983377#ent", "<e1>", "SNCA", ")", "can", "cause", "Parkinson", "disease", "PD", ")", "and", "C0752347#ent", "<e2>", "the", "same", "kindred", "."], "h": {"id": "C2983377", "name": "C2983377#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0752347", "name": "C0752347#ent", "pos": [20, 21]}}
{"token": ["Tobramycin", "alone", "and", "in", "combination", "with", "C0032950#ent", "<e1>", "also", "significantly", "reduced", "C0024141#ent", "<e2>", ",", "compared", "with", "no", "treatment", "P", "<", "or", "=", "0.006", ")", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [11, 12]}}
{"token": ["This", "study", "was", "aimed", "to", "verify", "if", "captopril", "was", "able", "to", "reduce", "plasma", "C3273436#ent", "<e1>", "during", "thrombolysis", "in", "C0155626#ent", "<e2>", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0155626", "name": "C0155626#ent", "pos": [18, 19]}}
{"token": ["C0073243#ent", "<e1>", "partially", "purified", ",", "with", "only", "a", "few", "C0086376#ent", "<e2>", "detectable", "in", "active", "fractions", "a", "final", "glycerol", "gradient", "."], "h": {"id": "C0073243", "name": "C0073243#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["Therefore", ",", "C1516312#ent", "<e1>", "be", "useful", "tools", "to", "study", "the", "role", "of", "C0255873#ent", "<e2>", "in", "these", "diseases", "and", "other", "biological", "phenomena", "and", "which", "can", "be", "developed", "into", "chemotherapeutic", "agents"], "h": {"id": "C1516312", "name": "C1516312#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0255873", "name": "C0255873#ent", "pos": [12, 13]}}
{"token": ["C1415301#ent", "<e1>", "mRNA", "expression", "predominated", "over", "those", "of", "NR2A", "and", "C3538769#ent", "<e2>", "mRNA", "in", "most", "neurones", "."], "h": {"id": "C1415301", "name": "C1415301#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538769", "name": "C3538769#ent", "pos": [10, 11]}}
{"token": ["The", "in", "vitro", "of", "thymosin", "fraction", "5", "a", "C1305923#ent", "<e1>", "the", "thymus", "gland", "on", "C2986972#ent", "<e2>", "ER", "formatin", "also", "determined", "in", "these", "patients", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2986972", "name": "C2986972#ent", "pos": [14, 15]}}
{"token": ["Deficiency", "of", "these", "C0014442#ent", "<e1>", ",", "especially", "very", "C1439272#ent", "<e2>", "VLCAD", ")", ",", "usually", "leads", "to", "severe", "human", "organic", "diseases", "such", "as", "sudden", "death", "infancy", ",", "infantile", "cardiomyopathy", "CM", ")", ",", "hypoketotic", "hypoglycemia", "or", "hepatic", "dysfunction"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1439272", "name": "C1439272#ent", "pos": [8, 9]}}
{"token": ["These", "data", "suggested", "that", "the", "metabolism", "of", "C0005096#ent", "<e1>", "was", "mediated", "by", "three", "slightly", "different", "C0014442#ent", "<e2>"], "h": {"id": "C0005096", "name": "C0005096#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["The", "C8-inactivated", "P450", "had", "a", "62", "%", "lower", "rate", "of", "reduction", "in", "the", "absence", "or", "presence", "of", "C0005096#ent", "<e1>", "compared", "to", "the", "native", "C0014442#ent", "<e2>", "."], "h": {"id": "C0005096", "name": "C0005096#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [23, 24]}}
{"token": ["Genetic", "exploration", "other", "family", "members", "C0011849#ent", "<e1>", "might", "provide", "further", "insight", "into", "the", "nature", "of", "C0158981#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0158981", "name": "C0158981#ent", "pos": [15, 16]}}
{"token": ["The", "inductive", "effects", "of", "C0001002#ent", "<e1>", "on", "cytochromes", "P450", "1A", "2B", "and", "2E", "in", "C0023899#ent", "<e2>", ",", "kidney", "and", "lung", "were", "studied", "using", "hamsters", "administered", "C0001002#ent", "<e1>", "in", "drinking", "water"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0001002", "name": "C0001002#ent", "pos": [4, 5]}}
{"token": ["Here", ",", "we", "show", "that", "C2936882#ent", "<e1>", "down-regulates", "while", "nicotine", "up-regulates", "C0389995#ent", "<e2>", "and", "that", "nicotine", "counteracts", "the", "inhibitory", "effect", "of", "C2936882#ent", "<e1>", "on", "angiotensin", "II-induced", "Rho-kinase", "expression", "."], "h": {"id": "C0389995", "name": "C0389995#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [5, 6]}}
{"token": ["The", "recent", "observation", "that", "Rho", "kinase", "phosphorylates", "RLC", "in", "vitro", "that", "C1420479#ent", "<e1>", "than", "those", "in", "the", "C0027120#ent", "<e2>", "MLCK", ")", "family", "have", "the", "potential", "to", "activate", "myosin", "II"], "h": {"id": "C1420479", "name": "C1420479#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027120", "name": "C0027120#ent", "pos": [17, 18]}}
{"token": ["We", "have", "briefly", "presented", "practical", "approaches", "to", "the", "management", "of", "the", "most", "common", "disorders", "caused", "by", "sexually", "transmitted", "pathogens", ",", "including", "C0242172#ent", "<e1>", "urethritis", "in", "men", ",", "genital", "lesions", "vaginal", "discharge", "and", "C0153188#ent", "<e2>", "."], "h": {"id": "C0242172", "name": "C0242172#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0153188", "name": "C0153188#ent", "pos": [32, 33]}}
{"token": ["The", "inhibition", "of", "C0001214#ent", "<e1>", "release", "by", "C0733397#ent", "<e2>", "can", "be", "eliminated", "by", "adding", "15-HETE", "or", "15-HPETE", "to", "the", "incubation", "medium"], "h": {"id": "C0001214", "name": "C0001214#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0733397", "name": "C0733397#ent", "pos": [7, 8]}}
{"token": ["HDL", "fractions", "from", "C0020473#ent", "<e1>", "patients", "are", "unable", "to", "displace", "C2826547#ent", "<e2>", "from", "the", "cell", "surface"], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C2826547", "name": "C2826547#ent", "pos": [10, 11]}}
{"token": ["Single", "photon", "emission", "computed", "tomography", "SPECT", ")", "with", "[123I]beta-CIT", "as", "a", "dopamine", "transporter", "ligand", "was", "used", "to", "assess", "nigrostriatal", "dopaminergic", "function", "25", "C2364082#ent", "<e1>", "and", "23", "normosmic", "relatives", "of", "C3160718#ent", "<e2>", "patients", "."], "h": {"id": "C2364082", "name": "C2364082#ent", "pos": [22, 23]}, "relation": "manifestation_of", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [29, 30]}}
{"token": ["The", "inhibitory", "effects", "of", "C0038766#ent", "<e1>", "on", "the", "contractions", "induced", "by", "prostaglandins", "F2", "alpha", "E2", "and", "C1415944#ent", "<e2>", ",", "norepinephrine", ",", "5-hydroxytryptamine", "(", "5-HT", ")", "or", "potassium", "chloride", "KCl", ")", "were", "examined", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415944", "name": "C1415944#ent", "pos": [16, 17]}}
{"token": ["Since", "cytochrome", "c", "the", "mitochondrially", "made", "C4284184#ent", "<e1>", "typical", "peripheral", "and", "C0021699#ent", "<e2>", "respectively", ",", "the", "present", "study", "suggests", "a", "useful", "approach", "for", "analyzing", "specific", "interactions", "between", "these", "different", "classes", "of", "membrane", "proteins"], "h": {"id": "C4284184", "name": "C4284184#ent", "pos": [6, 7]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [11, 12]}}
{"token": ["Clinical", "signs", "anorexia", ",", "hyperthermia", ",", "C0013404#ent", "<e1>", ",", "polyuria", ",", "ataxy", ",", "C0235082#ent", "<e2>", "seizures", "."], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0235082", "name": "C0235082#ent", "pos": [13, 14]}}
{"token": ["Substitution", "of", "C3539946#ent", "<e1>", "the", "core", "Rb-binding", "sequence", "reduced", "pRb", "and", "C2984536#ent", "<e2>", "binding", "in", "vitro", "decreased", "or", "abolished", "immortalization", "of", "rat", "embryo", "fibroblasts", "in", "vivo"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2984536", "name": "C2984536#ent", "pos": [11, 12]}}
{"token": ["Human", "C0002313#ent", "<e1>", "is", "a", "very", "important", "C2717971#ent", "<e2>", "which", "is", "involved", "in", "physiologically", "vital", "processes", "hemostasis", ",", "thrombosis", ",", "and", "activation", "of", "platelets", "."], "h": {"id": "C0002313", "name": "C0002313#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [7, 8]}}
{"token": ["We", "investigated", "the", "effects", "of", "biglycan", "and", "decorin", "on", "the", "inhibition", "of", "C0002313#ent", "<e1>", "by", "the", "C2717971#ent", "<e2>", "heparin", "cofactor", "II"], "h": {"id": "C0002313", "name": "C0002313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [16, 17]}}
{"token": ["This", "was", "not", "significantly", "changed", "by", "both", "C2936568#ent", "<e1>", "while", "these", "C0035064#ent", "<e2>", "alone", "probably", "stimulate", "tumour", "cell", "division", "4", "and", "24", "h", "after", "administration", "."], "h": {"id": "C2936568", "name": "C2936568#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["After", "nigral", "grafting", "however", ",", "intense", "C1706383#ent", "<e1>", "expression", "was", "observed", "in", "the", "striatum", ",", "and", "C0071924#ent", "<e2>", "and", "C0071924#ent", "<e2>", "mRNA", "levels", "returned", "to", "normal", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0071924", "name": "C0071924#ent", "pos": [16, 17]}}
{"token": ["Upon", "tyrosine", "phosphorylation", "C1416857#ent", "<e1>", "and", "LIR-2", "associate", "with", "the", "C1430988#ent", "<e2>", "SHP-1", ",", "and", "have", "been", "shown", "to", "inhibit", "Fc", "gamma", "RI", "when", "co-crosslinked", "in", "monocytes", "."], "h": {"id": "C1416857", "name": "C1416857#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [10, 11]}}
{"token": ["The", "predicted", "C3274867#ent", "<e1>", "the", "FOP", "N-terminus", "leucine-rich", "region", "fused", "to", "the", "catalytic", "domain", "C0919509#ent", "<e2>", "."], "h": {"id": "C3274867", "name": "C3274867#ent", "pos": [2, 3]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C0919509", "name": "C0919509#ent", "pos": [14, 15]}}
{"token": ["C1706574#ent", "<e1>", ",", "neurotensin", ",", "and", "C1337111#ent", "<e2>", "were", "identified", "in", "extracts", "of", "smooth", "muscle", "immuno-chemical", "and", "chromatographic", "analysis"], "h": {"id": "C1706574", "name": "C1706574#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [6, 7]}}
{"token": ["Bronchial", "endocrine", "cells", "gastrin-releasing", "peptide", "C1706574#ent", "<e1>", ")", ",", "a", "mammalian", "analog", "bombesin", ",", "and", "C1337111#ent", "<e2>", "ACTH", ")", "were", "immunohistochemically", "localized", "in", "paraffin", "sections", "of", "normal", "and", "pathologic", "human", "lungs", "."], "h": {"id": "C1706574", "name": "C1706574#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [15, 16]}}
{"token": ["We", "studied", "the", "role", "of", "cyclooxygenase", "products", "C0127400#ent", "<e1>", "of", "these", "pathophysiological", "responses", "pretreating", "sheep", "with", "either", "C0025041#ent", "<e2>", "(", "4", "mg/kg", ")", "or", "ibuprofen", "(", "12.5", "mg/kg", ")", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025041", "name": "C0025041#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "a", "kinase", "inhibitor", "on", "growth", "of", "C1367721#ent", "<e1>", "estrogen", "receptor", "negative", "ER-", ")", "breast", "cancer", "in", "vivo", "role", "of", "nuclear", "factor", "kappa", "B", "C1417708#ent", "<e2>", ")", "on", "tumorogenesis", "have", "been", "investigated", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [26, 27]}}
{"token": ["Because", "of", "significant", "substrate", "specificity", "differences", "among", "the", "C0055673#ent", "<e1>", "group", "of", "C3540790#ent", "<e2>", ",", "animal", "models", "overexpress", "primate", "chymases", "are", "crucial", "for", "delineating", "the", "in", "vivo", "function", "of", "these", "C3540790#ent", "<e2>", "."], "h": {"id": "C0055673", "name": "C0055673#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [12, 13]}}
{"token": ["C1414518#ent", "<e1>", "and", "MgCl2", "induced", "gelation", "of", "C0010803#ent", "<e2>", "by", "formation", "of", "bundles", "of", "birefringent", "macrofilaments", "."], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [7, 8]}}
{"token": ["The", "history", "and", "examination", "must", "bear", "in", "mind", "alternative", "and", "concomitant", "C0009326#ent", "<e1>", "such", "as", "mild", "systemic", "lupus", "erythematosus", "polyarticular", "osteoarthritis", "rheumatoid", "arthritis", "polymyalgia", "rheumatica", "C0268337#ent", "<e2>", "even", "osteomalacia", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268337", "name": "C0268337#ent", "pos": [25, 26]}}
{"token": ["The", "effect", "of", "C1421452#ent", "<e1>", "C0243192#ent", "<e2>", "(", "but", "not", "of", "the", "VPAC1", "C0243192#ent", "<e2>", ")", "persisted", "upon", "blockade", "of", "GABAergic", "transmission", "and", "was", "strongly", "attenuated", "upon", "inhibition", "of", "PKA", "."], "h": {"id": "C1421452", "name": "C1421452#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [5, 6]}}
{"token": ["Neither", "the", "OV-1", "nor", "the", "PRL-1", "protein", "strong", "homology", "with", "any", "previously", "characterised", "C0085536#ent", "<e1>", "suggesting", "that", "they", "probably", "belong", "to", "a", "new", "C1335403#ent", "<e2>"], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335403", "name": "C1335403#ent", "pos": [23, 24]}}
{"token": ["These", "data", "strongly", "support", "the", "hypothesis", "that", "C0284930#ent", "<e1>", "a", "novel", "C0010656#ent", "<e2>", "is", "expressed", "at", "high", "levels", "in", "osteoclasts", "."], "h": {"id": "C0284930", "name": "C0284930#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [11, 12]}}
{"token": ["The", "complete", "coding", "sequences", "the", "C1415155#ent", "<e1>", "of", "the", "beta", "subunit", "C0599208#ent", "<e2>", "the", "proband", "were", "analyzed", "for", "the", "presence", "of", "mutations", ",", "by", "either", "reverse-transcribed", "PCR", "or", "SSCP", "analysis"], "h": {"id": "C1415155", "name": "C1415155#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0599208", "name": "C0599208#ent", "pos": [11, 12]}}
{"token": ["The", "vegetable", "diets", "no", "effect", "C0796516#ent", "<e1>", "(", "CDNB", ")", "activity", ",", "irrespective", "of", "C1738886#ent", "<e2>", "genotype", "or", "sex", "."], "h": {"id": "C0796516", "name": "C0796516#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1738886", "name": "C1738886#ent", "pos": [14, 15]}}
{"token": ["Based", "on", "neuroprotective", "efficacy", "animal", "models", "we", "evaluated", "the", "N-methyl", "D-aspartate", "antagonist", "C0285608#ent", "<e1>", "in", "patients", "with", "C0948008#ent", "<e2>", "after", "doses", "up", "to", "1.5", "mg/kg", "were", "shown", "to", "be", "safe", "in", "phase", "1", "phase", "2a", "studies"], "h": {"id": "C0285608", "name": "C0285608#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0948008", "name": "C0948008#ent", "pos": [17, 18]}}
{"token": ["C1367710#ent", "<e1>", "generated", "by", "activated", "C1860224#ent", "<e2>", "was", "biologically", "(", "chemotactically", ")", "active", "."], "h": {"id": "C1367710", "name": "C1367710#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1860224", "name": "C1860224#ent", "pos": [5, 6]}}
{"token": ["Cell", "accumulation", "not", "inhibited", "by", "the", "C0085387#ent", "<e1>", "naproxen", ",", "indomethacin", ",", "C0040377#ent", "<e2>", "or", "aspirin", ",", "nor", "by", "the", "dual", "cyclo-oxygenase", "lipoxygenase", "inhibitors", "BW", "755C", "and", "benoxaprofen", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040377", "name": "C0040377#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "we", "show", "that", "the", "activation", "of", "Tpl2", "by", "C0812246#ent", "<e1>", "depends", "on", "signals", "transduced", "both", "C1366777#ent", "<e2>", "and", "RIP1", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366777", "name": "C1366777#ent", "pos": [18, 19]}}
{"token": ["Some", "years", "ago", ",", "compelling", "evidence", "was", "provided", "that", "cAMP", "stimulates", "NaCl", "reabsorption", "through", "the", "activation", "of", "C1382029#ent", "<e1>", "several", "hormones", "other", "than", "antidiuretic", "hormone", "C0001942#ent", "<e2>", ")", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [25, 26]}}
{"token": ["Sequencing", "revealed", "that", "exon", "3", "deleted", "from", "the", "C1333205#ent", "<e1>", "cDNA", ",", "resulting", "in", "a", "74-aa-long", "C1412821#ent", "<e2>", "to", "the", "generation", "of", "a", "premature", "stop", "codon"], "h": {"id": "C1333205", "name": "C1333205#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [16, 17]}}
{"token": ["Normal", "and", "C0024790#ent", "<e1>", "hematopoietic", "progenitors", "paired", "wild-type", "(", "WT", ")", "and", "C3272445#ent", "<e2>", "used", "for", "analysis", "of", "intracellular", "and", "surface", "PrP(c", ")", "expression", "using", "flow", "cytometry", "Western", "blot"], "h": {"id": "C0024790", "name": "C0024790#ent", "pos": [2, 3]}, "relation": "associated_with_malfunction_of_gene_product", "t": {"id": "C3272445", "name": "C3272445#ent", "pos": [12, 13]}}
{"token": ["This", "heterodimer", ",", "but", "neither", "P1", "or", "C1419693#ent", "<e1>", "alone", ",", "tightly", "bound", "to", "C1419691#ent", "<e2>", "and", "formed", "a", "pentameric", "complex", ",", "presumably", "as", "P0(P1-P2)2", ",", "assumed", "from", "its", "molecular", "weight", "from", "sedimentation", "analysis"], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419691", "name": "C1419691#ent", "pos": [14, 15]}}
{"token": ["Primitive", "corticostriate", "arbors", "form", "by", "postnatal", "day", "2", "C1419693#ent", "<e1>", ";", "day", "of", "birth", "is", "C1419691#ent", "<e2>", ")", "and", "develop", "further", "by", "P7", "."], "h": {"id": "C1419693", "name": "C1419693#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1419691", "name": "C1419691#ent", "pos": [15, 16]}}
{"token": ["The", "C2827557#ent", "<e1>", "potency", "for", "activating", "phosphoinositidase", "C", "increasing", "intracellular", "Ca2", "+", "(", "C1537501#ent", "<e2>", ">", "DABK", ")", "was", "opposite", "that", "for", "inhibiting", "mitogenesis", "(", "DABK", ">", "C1537501#ent", "<e2>", ")", "."], "h": {"id": "C2827557", "name": "C2827557#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [13, 14]}}
{"token": ["C1335591#ent", "<e1>", "RAR-beta", ")", "expression", "decreases", "in", "human", "premalignant", "oral", "lesions", "C1424494#ent", "<e2>", ")", "."], "h": {"id": "C1335591", "name": "C1335591#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424494", "name": "C1424494#ent", "pos": [11, 12]}}
{"token": ["Decreased", "C1367675#ent", "<e1>", "and", "increased", "C1415619#ent", "<e2>", "were", "commonly", "observed", "among", "the", "four", "direct", "toxicants", ",", "which", "appeared", "to", "be", "responses", "to", "cellular", "damage"], "h": {"id": "C1367675", "name": "C1367675#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415619", "name": "C1415619#ent", "pos": [5, 6]}}
{"token": ["We", "speculate", "that", "the", "underlying", "C0522274#ent", "<e1>", "associated", "with", "cirrhosis", "increase", "the", "risk", "of", "spontaneous", "C0270629#ent", "<e2>", "should", "raise", "concern", "for", "this", "infection", "when", "cirrhotic", "patients", "present", "with", "fever", "and", "back", "pain"], "h": {"id": "C0522274", "name": "C0522274#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0270629", "name": "C0270629#ent", "pos": [15, 16]}}
{"token": ["This", "also", "suggests", "a", "pathway", "by", "which", "a", "C1364081#ent", "<e1>", "influence", "the", "transcription", "of", "several", "C1417679#ent", "<e2>", "in", "the", "nucleus", "."], "h": {"id": "C1364081", "name": "C1364081#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [15, 16]}}
{"token": ["C1523975#ent", "<e1>", "which", "replicates", "and", "repairs", "mitochondrial", "DNA", "requires", "the", "C1415155#ent", "<e2>", "processivity", "."], "h": {"id": "C1523975", "name": "C1523975#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415155", "name": "C1415155#ent", "pos": [10, 11]}}
{"token": ["The", "genome", "structure", "C1119918#ent", "<e1>", "similar", "in", "size", "and", "C0079429#ent", "<e2>", "order", "to", "that", "of", "tobacco", "cpDNA", "."], "h": {"id": "C1119918", "name": "C1119918#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["Thoracic", "stent-grafts", "(", "C1421245#ent", "<e1>", ")", "show", "excellent", "early", "and", "mid-term", "results", "for", "localized", "C0012634#ent", "<e2>", "of", "the", "descending", "aorta"], "h": {"id": "C1421245", "name": "C1421245#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["The", "C0034861#ent", "<e1>", "with", "our", "specific", "monoclonal", "antibody", "with", "IgE", "from", "patients", "with", "C0011615#ent", "<e2>"], "h": {"id": "C0034861", "name": "C0034861#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "the", "filamin", "C", "gene", "C1414637#ent", "<e1>", ")", "cause", "a", "C2678065#ent", "<e2>", "MFM", ")", ",", "morphologically", "characterized", "by", "focal", "myofibrillar", "destruction", "abnormal", "accumulation", "of", "several", "proteins", "within", "skeletal", "muscle", "fibres"], "h": {"id": "C1414637", "name": "C1414637#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C2678065", "name": "C2678065#ent", "pos": [11, 12]}}
{"token": ["C0022478#ent", "<e1>", "excretion", "was", "also", "measured", "in", "New", "Zealand", "C1516876#ent", "<e2>", "hypertensive", "rats", "and", "in", "normotensive", "Wistar-Otago", "rats", "(", "controls", ")", "."], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [9, 10]}}
{"token": ["These", "results", "show", "that", "C0022478#ent", "<e1>", "causes", "a", "sustained", "reduction", "of", "blood", "pressure", "C1516876#ent", "<e2>", "hypertensive", "rats", "and", "provide", "important", "information", "for", "a", "potential", "gene", "therapy", "to", "human", "hypertension", "and", "related", "diseases", "."], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [13, 14]}}
{"token": ["To", "examine", "whether", "2", "sympatholytic", "medications", "decrease", "C0751771#ent", "<e1>", "prevent", "the", "rise", "in", "sympathetic", "activity", "preceding", "the", "onset", "of", "C0751771#ent", "<e1>", "propranolol", ",", "a", "C0304516#ent", "<e1>", "and", "clonidine", ",", "a", "selective", "alpha2-agonist", "."], "h": {"id": "C0751771", "name": "C0751771#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [24, 25]}}
{"token": ["While", "the", "effects", "of", "IL-6", "are", "mediated", "through", "stimulation", "of", "its", "C1366325#ent", "<e1>", "the", "IFN-alpha-induced", "survival", "of", "myeloma", "cells", "independent", "of", "C1325331#ent", "<e2>", "as", "demonstrated", "using", "a", "neutralizing", "anti-gp130", "Ab", ")", "."], "h": {"id": "C1366325", "name": "C1366325#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1325331", "name": "C1325331#ent", "pos": [21, 22]}}
{"token": ["None", "of", "57", "brain-derived", "T", "cell", "clones", "proliferated", "to", "either", "MBP", "or", "C1418882#ent", "<e1>", ",", "although", "they", "responded", "well", "to", "C0030779#ent", "<e2>", "and", "IL", "2"], "h": {"id": "C1418882", "name": "C1418882#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [20, 21]}}
{"token": ["These", "observations", "are", "discussed", "in", "light", "of", "potential", "mechanisms", "regulating", "the", "C1420295#ent", "<e1>", "expression", "of", "the", "C1707844#ent", "<e2>", "and", "Ren-2", "loci", "."], "h": {"id": "C1420295", "name": "C1420295#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1707844", "name": "C1707844#ent", "pos": [16, 17]}}
{"token": ["In", "experimental", "C0023290#ent", "<e1>", "interleukin", "(IL)-12", "initiates", "control", "over", "Leishmania", "donovani", "C3540579#ent", "<e2>", "activation", ",", "interferon", "(IFN)-gamma", "secretion", ",", "and", "granuloma", "formation"], "h": {"id": "C0023290", "name": "C0023290#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [11, 12]}}
{"token": ["All", "except", "1", "C4084798#ent", "<e1>", "patient", "exhibited", "slowness", "of", "C0030196#ent", "<e2>", "movements", "without", "rigidity", "or", "rest", "tremor"], "h": {"id": "C4084798", "name": "C4084798#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [9, 10]}}
{"token": ["C0017337#ent", "<e1>", "expressed", "at", "similar", "levels", "included", "gastrin", ",", "C1417498#ent", "<e2>", "and", "pS2", ",", "which", "are", "important", "in", "gastric", "function"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417498", "name": "C1417498#ent", "pos": [9, 10]}}
{"token": ["There", "are", "close", "sequence", "similarities", "between", "C1704947#ent", "<e1>", "and", "both", "growth", "hormone", "releasing", "factor", "C1706512#ent", "<e2>", ")", "and", "vasoactive", "intestinal", "polypeptide", "VIP", ")", "and", "between", "NPY", "and", "pancreatic", "polypeptide"], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706512", "name": "C1706512#ent", "pos": [14, 15]}}
{"token": ["The", "expression", "of", "C1334087#ent", "<e1>", "investigated", "in", "several", "autoimmune", "blistering", "C0162628#ent", "<e2>", "bullous", "pemphigoid", "BP", ")", ",", "epidermolysis", "bullosa", "acquisita", "EBA", ")", ",", "bullous", "systemic", "lupus", "erythematosus", "BSLE", ")", ",", "and", "pemphigus", "vulgaris", "PV", ")", "by", "an", "indirect", "immunofluorescence", "technique"], "h": {"id": "C1334087", "name": "C1334087#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "we", "found", "that", "C1321914#ent", "<e1>", "and", "Puma", "synergistically", "activate", "Bax", "and", "C1706876#ent", "<e2>", ",", "and", "induce", "apoptosis", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1706876", "name": "C1706876#ent", "pos": [15, 16]}}
{"token": ["Our", "objective", "was", "to", "evaluate", "the", "relationship", "between", "the", "disposition", "of", "sertraline", "and", "the", "presence", "of", "the", "C0960580#ent", "<e1>", "to", "define", "the", "contribution", "of", "cytochrome", "P450", "2C19", "C1332828#ent", "<e2>", ")", "to", "sertraline", "N-demethylation", "."], "h": {"id": "C0960580", "name": "C0960580#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1332828", "name": "C1332828#ent", "pos": [27, 28]}}
{"token": ["Prevalence", "and", "risk", "factors", "given", "so", "that", "clinicians", "may", "identify", "those", "C0009952#ent", "<e1>", "children", "at", "particularly", "high", "or", "low", "risk", "C1412376#ent", "<e2>", "for", "selective", "management"], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412376", "name": "C1412376#ent", "pos": [20, 21]}}
{"token": ["Preliminary", "results", "of", "our", "ongoing", "treatment", "trial", "that", "management", "of", "young", "C0009952#ent", "<e1>", "children", "with", "C1412376#ent", "<e2>", "as", "outpatients", "receiving", "oral", "cefixime", "as", "efficacious", "as", "inpatient", "management", "intravenous", "cefotaxime"], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412376", "name": "C1412376#ent", "pos": [15, 16]}}
{"token": ["In", "C0009952#ent", "<e1>", "children", "with", "chronic", "liver", "disease", "C1412376#ent", "<e2>", "should", "be", "considered", "in", "the", "differential", "diagnosis"], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412376", "name": "C1412376#ent", "pos": [8, 9]}}
{"token": ["Specific", "methylating", "activities", "caffeic", "acid", "C0054858#ent", "<e1>", "were", "obtained", "from", "the", "C0034861#ent", "<e2>", "renaturation", "of", "protein", "extracted", "from", "inclusion", "bodies", "from", "bacteria", "grown", "and", "induced", "at", "low", "temperature", "."], "h": {"id": "C0054858", "name": "C0054858#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "C0001975#ent", "<e1>", "act", "mainly", "as", "hydrogen", "bond", "donors", "whose", "binding", "to", "the", "C1305923#ent", "<e2>", "stabilized", "by", "hydrophobic", "interactions", "."], "h": {"id": "C0001975", "name": "C0001975#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [16, 17]}}
{"token": ["Two", "of", "these", "motifs", "are", "part", "of", "a", "highly", "conserved", "and", "inducible", "dyad", "symmetry", "element", "shown", "previously", "to", "control", "a", "remote", "C0879590#ent", "<e1>", "enhancer", "and", "the", "C1706333#ent", "<e2>", "promoter", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1706333", "name": "C1706333#ent", "pos": [26, 27]}}
{"token": ["Moreover", "in", "T", "cells", "C0879590#ent", "<e1>", "promoter", "activity", "enhanced", "upon", "coexpression", "of", "C1706333#ent", "<e2>", "but", "was", "inhibited", "by", "the", "coexpression", "of", "antisense", "Lad", "RNA", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706333", "name": "C1706333#ent", "pos": [12, 13]}}
{"token": ["The", "order", "of", "potency", "of", "drugs", "was", ":", "C0025853#ent", "<e1>", ">", "haloperidol", ">", "raclopride", ">", "C0073047#ent", "<e2>", ">"], "h": {"id": "C0025853", "name": "C0025853#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0073047", "name": "C0073047#ent", "pos": [15, 16]}}
{"token": ["Wortmannin", "(", "PI", "3-kinase", ";", "1", "microM", ")", "blocked", "C4082284#ent", "<e1>", "GSK-3", "phosphorylation", "completely", ",", "but", "adrenaline", "increased", "C4283740#ent", "<e2>", "Ser9", "phosphorylation", "in", "the", "presence", "of", "wortmannin", "."], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [18, 19]}}
{"token": ["The", "pathogenesis", "of", "C0004943#ent", "<e1>", "BD", ")", "and", "C0343190#ent", "<e2>", "PAN", ")", "is", "not", "yet", "well", "established", "."], "h": {"id": "C0004943", "name": "C0004943#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0343190", "name": "C0343190#ent", "pos": [8, 9]}}
{"token": ["We", "pre-exposed", "murine", "peritoneal-elicited", "macrophages", "soluble", "extracts", "of", "Brugia", "malayi", "C0018889#ent", "<e1>", "BMFE", ")", "before", "restimulating", "with", "BMFE", "or", "TLR", "C2987634#ent", "<e2>", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [20, 21]}}
{"token": ["All", "patients", "had", "severe", "or", "life-threatening", "disease", "manifestations", "including", "C0037299#ent", "<e1>", "renal", "disease", "hyperviscosity", "or", "C0042384#ent", "<e2>"], "h": {"id": "C0037299", "name": "C0037299#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [15, 16]}}
{"token": ["Immunofluorescence", "staining", "that", "PIC1/SUMO-1", "colocalized", "with", "Sp100", "and", "C0023524#ent", "<e1>", "in", "C0057753#ent", "<e2>", "except", "in", "mitotic", "cells", "in", "which", "C0023524#ent", "<e1>", "and", "Sp100", "are", "dissociated", "."], "h": {"id": "C0057753", "name": "C0057753#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [8, 9]}}
{"token": ["A", "case", "is", "described", "of", "deliberate", "ingestion", "of", "15", "g", "of", "C0077854#ent", "<e1>", "resulted", "in", "C3854173#ent", "<e2>", "dialytic", "therapy", "2", "weeks", ",", "refractory", "anaemia", "rhabdomyolysis", ",", "myocarditis", ",", "liver", "dysfunction", "a", "disproportionate", "coagulopathy", "and", "paralytic", "ileus"], "h": {"id": "C0077854", "name": "C0077854#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [15, 16]}}
{"token": ["This", "compound", "was", "found", "to", "inhibit", "the", "chymotrypsin-like", "site", "the", "C0286330#ent", "<e1>", "similar", "levels", "to", "known", "inhibitor", "clasto-lactacystin", "beta-lactone", "C0764177#ent", "<e2>", ")", "."], "h": {"id": "C0286330", "name": "C0286330#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0764177", "name": "C0764177#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "other", "common", "fatty", "acids", "as", "palmitate", "and", "C0220884#ent", "<e1>", "significantly", "stimulated", "C0011967#ent", "<e2>", "syntheisis", ",", "although", "arachidonate", "did", "not", "affect", "it", "."], "h": {"id": "C0220884", "name": "C0220884#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011967", "name": "C0011967#ent", "pos": [14, 15]}}
{"token": ["We", "report", "a", "Turkish", "boy", "who", "had", "C3665349#ent", "<e1>", "to", "a", "mutation", "in", "the", "thyroid", "peroxidase", "C1364508#ent", "<e2>", ")", "gene", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1364508", "name": "C1364508#ent", "pos": [16, 17]}}
{"token": ["Three", "siblings", "with", "goitre", "and", "latent", "to", "C3665349#ent", "<e1>", "suspected", "of", "having", "thyroid", "peroxidase", "C1364508#ent", "<e2>", ")", "abnormality", "."], "h": {"id": "C3665349", "name": "C3665349#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1364508", "name": "C1364508#ent", "pos": [14, 15]}}
{"token": ["Pick", "bodies", "ballooned", "neurons", "(", "Pick", "cells", "in", "C0006982#ent", "<e1>", "and", "C1417406#ent", "<e2>", ",", "and", "nigral", "corticobasal", "inclusions", "in", "C0006982#ent", "<e1>", "were", "immunoreactive", "for", "tau", "but", "not", "Ki-67", "."], "h": {"id": "C1417406", "name": "C1417406#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006982", "name": "C0006982#ent", "pos": [8, 9]}}
{"token": ["11-dihydrooracin", "(", "DHO", ")", "arises", "from", "the", "potential", "C0010858#ent", "<e1>", "the", "metabolic", "conversion", "of", "its", "prochiral", "centre", "(", "C1422418#ent", "<e2>", ")", "."], "h": {"id": "C0010858", "name": "C0010858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1422418", "name": "C1422418#ent", "pos": [18, 19]}}
{"token": ["Apo", "may", "be", "a", "useful", "agent", "to", "evaluate", "DA", "function", "in", "C0242350#ent", "<e1>", "patients", "and", "predict", "a", "therapeutic", "response", "long-acting", "C0013036#ent", "<e2>"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013036", "name": "C0013036#ent", "pos": [20, 21]}}
{"token": ["Other", "C0043528#ent", "<e1>", "under", "investigation", "include", "borrelosis", ",", "ehrlichiosis", ",", "the", "C0032064#ent", "<e2>", ",", "and", "other", "rickettsial", "diseases"], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0032064", "name": "C0032064#ent", "pos": [11, 12]}}
{"token": ["Because", "the", "hepatic", "lesions", "this", "animal", "resemble", "those", "of", "other", "C0043528#ent", "<e1>", "such", "as", "C0032064#ent", "<e2>", "and", "tularemia", ",", "veterinarians", "and", "laboratory", "personnel", "handle", "samples", "should", "take", "adequate", "safety", "precautions", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0032064", "name": "C0032064#ent", "pos": [14, 15]}}
{"token": ["Dextranomer", "is", "a", "hydrophilic", "dextran", "polymer", "advocated", "as", "a", "'", "cleansing", "agent", "'", "for", "various", "types", "of", "exudating", "wounds", "or", "C0149745#ent", "<e1>", ",", "including", "stasis", "(", "venous", ")", "ulcers", "and", "C0011127#ent", "<e2>"], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0011127", "name": "C0011127#ent", "pos": [30, 31]}}
{"token": ["In", "addition", ",", "aluminum", "fluoride", "an", "artificial", "activator", "C1708136#ent", "<e1>", "stimulates", "IP1", "and", "C2697645#ent", "<e2>", "formation", "."], "h": {"id": "C1708136", "name": "C1708136#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2697645", "name": "C2697645#ent", "pos": [13, 14]}}
{"token": ["We", "previously", "described", "that", "C3853652#ent", "<e1>", "LCK", ")", "and", "FYN", "C1417123#ent", "<e2>", "related", "to", "SRC", ",", "FGR", ",", "YES", "(", "FYN", ")", "mediate", "GC-induced", "inhibition", "of", "T-cell-receptor", "(", "TCR", ")", "signalling", "."], "h": {"id": "C3853652", "name": "C3853652#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [10, 11]}}
{"token": ["C0155616#ent", "<e1>", "uncertain", "mechanism", "may", "occur", "in", "hyperparathyroidism", ",", "C0020676#ent", "<e2>", "or", "acromegaly", "."], "h": {"id": "C0155616", "name": "C0155616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [9, 10]}}
{"token": ["The", "patients", "have", "therefore", "been", "classified", "as", "having", "C0026707#ent", "<e1>", "atypical", "mental", "regression", "rather", "than", "C4289847#ent", "<e2>", "variants", "with", "particularly", "severe", "bony", "abnormalities"], "h": {"id": "C0026707", "name": "C0026707#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4289847", "name": "C4289847#ent", "pos": [15, 16]}}
{"token": ["Babesiosis", ",", "a", "C0043528#ent", "<e1>", "caused", "by", "the", "protozoan", "C3666154#ent", "<e2>", "is", "usually", "not", "treated", "when", "the", "symptoms", "are", "mild", ",", "because", "the", "parasitemia", "appears", "to", "be", "transient", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3666154", "name": "C3666154#ent", "pos": [9, 10]}}
{"token": ["It", "was", "shown", "that", "epidermal", "growth", "factor", "EGF", ")", "requires", "intact", "C1335875#ent", "<e1>", ";", "on", "the", "other", "hand", "IL-4", "induces", "C3489584#ent", "<e2>", "expression", ",", "along", "with", "IL-13", ",", "through", "STAT", "6", "activation", "."], "h": {"id": "C1335875", "name": "C1335875#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3489584", "name": "C3489584#ent", "pos": [20, 21]}}
{"token": ["The", "loss", "of", "function", "WRN", ",", "a", "DNA", "helicase", "C0015296#ent", "<e1>", ",", "causes", "the", "C0231341#ent", "<e2>", "Werner", "syndrome"], "h": {"id": "C0015296", "name": "C0015296#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0231341", "name": "C0231341#ent", "pos": [14, 15]}}
{"token": ["DN", "T", "cells", "for", "C1826467#ent", "<e1>", "-", "69", "effectively", "presented", "GPMBP", "and", "were", "superior", "C0033036#ent", "<e2>", "compared", "to", "other", "CD4+", "T", "cells", "presentation", "of", "this", "antigen", "."], "h": {"id": "C1826467", "name": "C1826467#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [14, 15]}}
{"token": ["C2674616#ent", "<e1>", "then", "converts", "coagulation", "factor", "XI", "activated", "factor", "XI", "XIa", ")", "and", "C1416681#ent", "<e2>", "to", "kallikrein", "."], "h": {"id": "C2674616", "name": "C2674616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416681", "name": "C1416681#ent", "pos": [13, 14]}}
{"token": ["Two", "patients", "with", "apparent", "active", "lupus", "nephritis", "intermediate", "C1412179#ent", "<e1>", "levels", ",", "which", "were", "probably", "caused", "by", "antigen-antibody", "formation", "C0020951#ent", "<e2>", "deposition", "in", "the", "kidneys", "."], "h": {"id": "C1412179", "name": "C1412179#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [19, 20]}}
{"token": ["We", "believe", "C3899988#ent", "<e1>", "inheritance", "is", "the", "possible", "genetic", "etiology", "C3542407#ent", "<e2>", "in", "this", "family", "."], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3542407", "name": "C3542407#ent", "pos": [10, 11]}}
{"token": ["Hantaviruses", "cause", "2", "C0043528#ent", "<e1>", "hemorrhagic", "fever", "renal", "syndrome", "HFRS", ")", "and", "C0243025#ent", "<e2>"], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0243025", "name": "C0243025#ent", "pos": [12, 13]}}
{"token": ["We", "report", "a", "78-year-old", "man", "with", "C3890941#ent", "<e1>", "GBS", ")", "who", "showed", "upper", "limb", "dominant", "weakness", "following", "an", "C0041912#ent", "<e2>"], "h": {"id": "C3890941", "name": "C3890941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [18, 19]}}
{"token": ["Ebf2-null", "mice", "reveal", "a", "novel", "genetic", "cause", "hypogonadotropic", "hypogonadism", "C0235025#ent", "<e1>", "the", "mouse", ",", "disclosing", "an", "important", "role", "for", "C1426006#ent", "<e2>", "in", "neuronal", "migration", "nerve", "development", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1426006", "name": "C1426006#ent", "pos": [19, 20]}}
{"token": ["Melanocyte", "proliferation", "C0304402#ent", "<e1>", "are", "of", "interest", "as", "potential", "treatments", "for", "the", "depigmentary", "skin", "disorder", "C0042900#ent", "<e2>", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042900", "name": "C0042900#ent", "pos": [15, 16]}}
{"token": ["C1333365#ent", "<e1>", "hExo1", ")", "possesses", "both", "5'exonuclease", "and", "C0252912#ent", "<e2>", "activities", "and", "plays", "a", "role", "in", "DNA", "repair", "recombination", ",", "and", "replication", "."], "h": {"id": "C1333365", "name": "C1333365#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0252912", "name": "C0252912#ent", "pos": [8, 9]}}
{"token": ["Eleven", "out", "of", "24", "patients", "with", "C1290138#ent", "<e1>", "radiological", "features", "of", "C1692871#ent", "<e2>"], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1692871", "name": "C1692871#ent", "pos": [11, 12]}}
{"token": ["Because", "the", "transcription", "factor", "nuclear", "factor", "kappaB", "C2986464#ent", "<e1>", ")", "is", "involved", "in", "C0033581#ent", "<e2>", "oncogenesis", ",", "we", "tested", "whether", "Res", "could", "modulate", "NF-kappaB", "activity"], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [13, 14]}}
{"token": ["In", "patients", "with", "DCM", ",", "C0126174#ent", "<e1>", "treatment", "improves", "the", "cardiac", "autonomic", "adaptation", "increases", "urine", "output", "response", "to", "C0020488#ent", "<e2>"], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020488", "name": "C0020488#ent", "pos": [18, 19]}}
{"token": ["C0001927#ent", "<e1>", "aerosol", "is", "the", "drug", "of", "choice", "for", "prevention", "of", "C0004099#ent", "<e2>"], "h": {"id": "C0001927", "name": "C0001927#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [11, 12]}}
{"token": ["Further", "studies", "demonstrated", "that", "ESW", "induced", "ERK", "activation", ",", "and", "blockage", "of", "O(2)(-", ")", "production", "or", "inhibition", "of", "C1421249#ent", "<e1>", "but", "not", "protein", "kinase", "A", "C3494348#ent", "<e2>", "suppressed", "ESW-induced", "ERK", "activation", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3494348", "name": "C3494348#ent", "pos": [25, 26]}}
{"token": ["We", "performed", "an", "analysis", "of", "the", "regulatory", "region", "C0342684#ent", "<e1>", ",", "the", "murine", "C1334043#ent", "<e2>", "of", "the", "gene", "that", "is", "mutated", "in", "the", "X-linked", "form", "ocular", "albinism", "as", "Oa1", "'s", "function", "affects", "melanosome", "biogenesis"], "h": {"id": "C0342684", "name": "C0342684#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}}
{"token": ["Our", "conclusion", "suggests", "that", "the", "electrophysiological", "actions", "of", "dopamine", "and", "C0013036#ent", "<e1>", "dopaminergic", "cells", "the", "ventral", "mesencephalon", "be", "indicative", "of", "the", "pharmacological", "effects", "these", "C0991617#ent", "<e2>", "on", "the", "brain", "."], "h": {"id": "C0013036", "name": "C0013036#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [24, 25]}}
{"token": ["The", "hallmarks", "of", "rheumatic", "fever", "arthritis", ",", "carditis", ",", "cutaneous", "disease", "C0152113#ent", "<e1>", ",", "and", "subsequent", "acquired", "C3258293#ent", "<e2>"], "h": {"id": "C0152113", "name": "C0152113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3258293", "name": "C3258293#ent", "pos": [17, 18]}}
{"token": ["C0139121#ent", "<e1>", "and", "verapamil", "also", "increased", "C1705526#ent", "<e2>", "expression", "at", "48", "h", "(", "p<0.05", ")", "."], "h": {"id": "C0139121", "name": "C0139121#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [6, 7]}}
{"token": ["In", "vivo", "studies", "in", "this", "model", "of", "C0008370#ent", "<e1>", "with", "the", "use", "of", "C1883695#ent", "<e2>", "antagonist", "will", "shed", "light", "on", "the", "possible", "role", "of", "opioidergic", "regulation", "of", "liver", "regeneration"], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1883695", "name": "C1883695#ent", "pos": [13, 14]}}
{"token": ["By", "contrast", ",", "neither", "the", "11", "C0038296#ent", "<e1>", "metyrapone", ",", "nor", "the", "C0003277#ent", "<e2>", "aminoglutethimide", ",", "diminished", "the", "effects", "of", "SL", "or", "of", "7", "alpha-thio-SL", "on", "cortisol", "secretion"], "h": {"id": "C0038296", "name": "C0038296#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003277", "name": "C0003277#ent", "pos": [12, 13]}}
{"token": ["Although", "many", "studies", "indicate", "that", "the", "stimulation", "of", "C3890198#ent", "<e1>", "leads", "to", "C2986464#ent", "<e2>", "the", "molecular", "mechanism", "which", "C3890198#ent", "<e1>", "induced", "C2986464#ent", "<e2>", "largely", "unknown", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3890198", "name": "C3890198#ent", "pos": [8, 9]}}
{"token": ["The", "same", "doses", "of", "C0525773#ent", "<e1>", "that", "increased", "preference", "in", "sham-lesioned", "animals", ",", "decreased", "C0036023#ent", "<e2>", "and", "water", "intakes", "lesioned", "rats", "."], "h": {"id": "C0525773", "name": "C0525773#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036023", "name": "C0036023#ent", "pos": [14, 15]}}
{"token": ["Our", "studies", "suggest", "that", "SFFV-infected", "erythroid", "cells", "become", "transformed", "when", "differentiation", "signals", "activated", "by", "STAT1/3", "are", "blocked", "due", "to", "high", "C1335283#ent", "<e1>", "levels", "induced", "by", "inappropriate", "expression", "of", "the", "C0919490#ent", "<e2>"], "h": {"id": "C1335283", "name": "C1335283#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [29, 30]}}
{"token": ["C0633460#ent", "<e1>", "was", "more", "potent", "than", "C0020740#ent", "<e2>", "and", "orpanoxin", "in", "the", "rat", "brewer's", "pyresis", "model", "."], "h": {"id": "C0633460", "name": "C0633460#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [6, 7]}}
{"token": ["Both", "NS-398", "and", "Dup-697", "exhibited", "time-dependent", "inactivation", "of", "hCOX-2", ",", "as", "did", "C0021246#ent", "<e1>", "on", "both", "C3540790#ent", "<e2>", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}}
{"token": ["This", "effect", "disappeared", "in", "presence", "of", "C0021246#ent", "<e1>", ",", "an", "inhibitor", "of", "COX", "C3540790#ent", "<e2>", ",", "and", "PGE2", "injected", "to", "the", "animals", "imitated", "the", "effect", "of", "TNF-alpha", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [13, 14]}}
{"token": ["All", "participants", "had", "a", "SHBG", "serum", "concentration", "below", "60", "nmol/liter", "at", "baseline", "and", "had", "stable", "C0011849#ent", "<e1>", "controlled", "by", "either", "oral", "C0020616#ent", "<e2>", "diet", "for", "1", "month", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0020616", "name": "C0020616#ent", "pos": [21, 22]}}
{"token": ["The", "tyrosine", "kinase", "blocker", "C0600438#ent", "<e1>", "prevented", "activation", "of", "Jak2", "but", "not", "C0812307#ent", "<e2>", ",", "suggesting", "that", "Jak2", "is", "the", "specific", "target", "for", "C0600438#ent", "<e1>", "eosinophils", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0600438", "name": "C0600438#ent", "pos": [4, 5]}}
{"token": ["In", "addition", ",", "since", "C0812307#ent", "<e1>", "remained", "unaffected", "by", "C0600438#ent", "<e2>", "it", "is", "unlikely", "that", "Jak2", "is", "required", "for", "Lyn", "activation", "in", "this", "model", "."], "h": {"id": "C0812307", "name": "C0812307#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0600438", "name": "C0600438#ent", "pos": [9, 10]}}
{"token": ["C1415900#ent", "<e1>", "binding", "initiated", "phosphorylation", "of", "Jak1", "and", "Tyk2", "C0031727#ent", "<e2>", "leading", "to", "Stat1/Stat2", "activation", ",", "nuclear", "translocation", "and", "transactivation", "of", "an", "ISRE-luciferase", "reporter", "gene", "construct", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [9, 10]}}
{"token": ["While", "screening", "a", "cohort", "of", "women", "with", "POF", "for", "C2700049#ent", "<e1>", "premutations", ",", "a", "more", "distal", "trinucleotide", "repeat", "C1414810#ent", "<e2>", ",", "was", "also", "tested", "."], "h": {"id": "C2700049", "name": "C2700049#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414810", "name": "C1414810#ent", "pos": [18, 19]}}
{"token": ["The", "stereoselectivity", "of", "the", "C0010762#ent", "<e1>", "flavin", "containing", "C0038311#ent", "<e2>", "as", "well", "as", "the", "role", "of", "hemoglobin", "and", "lipid", "peroxidation", "the", "primary", "metabolism", "xenobiotics", "is", "discussed", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038311", "name": "C0038311#ent", "pos": [8, 9]}}
{"token": ["The", "ROT3", "gene", "a", "C0010762#ent", "<e1>", "CYP90C1", ")", "with", "domains", "homologous", "to", "regions", "of", "C0038311#ent", "<e2>", "animals", "and", "plants", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0038311", "name": "C0038311#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "the", "involvement", "of", "IL-6/STAT3", "signaling", "in", "C1705631#ent", "<e1>", "Ialpha", "protein", "and", "examined", "whether", "REG", "Ialpha", "protein", "an", "anti-apoptotic", "effect", "of", "C1367307#ent", "<e2>", "signaling", "in", "gastric", "cancer", "cells"], "h": {"id": "C1705631", "name": "C1705631#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [22, 23]}}
{"token": ["We", "report", "our", "experience", "of", "sinus", "tract", "endoscopy", "C3811127#ent", "<e1>", ")", "and", "endoscopic", "retrograde", "cholangiopancreatography", "ERCP", ")", "in", "the", "treatment", "of", "C0267953#ent", "<e2>", "abscess", "."], "h": {"id": "C3811127", "name": "C3811127#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0267953", "name": "C0267953#ent", "pos": [21, 22]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "assess", "the", "health", "status", "patients", "with", "severe", "C0003873#ent", "<e1>", "over", "a", "long-term", "followup", "period", "after", "treatment", "with", "C1427267#ent", "<e2>", "+", "HSCT", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1427267", "name": "C1427267#ent", "pos": [23, 24]}}
{"token": ["Drug-induced", "gingival", "is", "an", "C0020732#ent", "<e1>", "by", "the", "use", "of", "C0031507#ent", "<e2>", ",", "cyclosporine", ",", "nifedipine", ",", "and", "other", "medications", "in", "the", "susceptible", "patient", "."], "h": {"id": "C0020732", "name": "C0020732#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [10, 11]}}
{"token": ["The", "enzyme", "activity", "inhibited", "by", "soy", "bean", "trypsin", "inhibitor", "alpha", "1", "antitrypsin", "but", "not", "by", "C0013618#ent", "<e1>", "suggesting", "that", "it", "was", "predominantly", "a", "serine", "proteinase", "probably", "C0064833#ent", "<e2>"], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [26, 27]}}
{"token": ["The", "fluoride", "combination", "a", "significant", "C0011334#ent", "<e1>", "protective", "influence", "which", "was", "equal", "to", "C1333690#ent", "<e2>", "when", "the", "last", "was", "used", "in", "the", "same", "concentration", "."], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [13, 14]}}
{"token": ["2", "The", "5-hydroxytryptophan-induced", "increase", "of", "MTA", "of", "suprahyoideal", "muscle", "in", "rats", "pretreated", "with", "C0030557#ent", "<e1>", "was", "not", "blocked", "by", "C0020934#ent", "<e2>", "but", "was", "blocked", "by", "methysergide", "."], "h": {"id": "C0030557", "name": "C0030557#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020934", "name": "C0020934#ent", "pos": [19, 20]}}
{"token": ["Primary", "infections", "infected", "decubitus", "ulcer", "7", ")", ",", "peritonitis", ",", "intra", "abdominal", "abscess", "C0036690#ent", "<e1>", "(", "2", "cases", "in", "each", "group", ")", ",", "C0034215#ent", "<e2>", ",", "Bartholin's", "gland", "abscess", "and", "Fournier's", "gangrene", "1", "case", "in", "each", "group", ")", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0034215", "name": "C0034215#ent", "pos": [23, 24]}}
{"token": ["However", ",", "administration", "of", "a", "beta(3)-adrenoceptor", "C0243192#ent", "<e1>", ",", "BRL-35153A", ",", "led", "to", "a", "significant", "increase", "in", "C2987341#ent", "<e2>", "mRNA", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987341", "name": "C2987341#ent", "pos": [17, 18]}}
{"token": ["Isonicotinic", "acid", "hydrazide", "isoniazid", ")", "and", "C0022209#ent", "<e1>", "iproniazid", ")", "were", "reversible", "noncompetitive", "inhibitors", "of", "C0796002#ent", "<e2>", "and", "exhibited", "K(i", ")", "values", "of", "8", "and", "186", "microM", ",", "respectively", "."], "h": {"id": "C0022209", "name": "C0022209#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0796002", "name": "C0796002#ent", "pos": [15, 16]}}
{"token": ["of", "the", "non-competitive", "NMDA", "receptor", "antagonist", ",", "MK-801", "(", "C0079246#ent", "<e1>", ")", ",", "and", "the", "C0003299#ent", "<e2>", "valproate", ",", "were", "studied", "in", "amygdala-kindled", "and", "non-kindled", "rats", "."], "h": {"id": "C0079246", "name": "C0079246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [15, 16]}}
{"token": ["However", ",", "the", "diuretic", "response", "C0016860#ent", "<e1>", "was", "increased", "in", "C0035436#ent", "<e2>", "rats", "compared", "with", "control", "rats"], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035436", "name": "C0035436#ent", "pos": [10, 11]}}
{"token": ["We", "hypothesized", "that", "C1412849#ent", "<e1>", "variants", "might", "confer", "a", "human", "leukocyte", "antigen", "risk", "for", "chronic", "beryllium", "disease", "C0006863#ent", "<e2>", ")", ",", "a", "granulomatous", "lung", "disease", "similar", "clinical", ",", "radiological", ",", "and", "pathological", "features", "to", "sarcoidosis", "."], "h": {"id": "C1412849", "name": "C1412849#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006863", "name": "C0006863#ent", "pos": [17, 18]}}
{"token": ["She", "suffered", "from", "C0085605#ent", "<e1>", "mild", "encephalopathy", "by", "several", "exacerbations", "associated", "with", "C0020592#ent", "<e2>", "and", "opioid", "therapy"], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [12, 13]}}
{"token": ["The", "constrictor", "effects", "of", "C0700481#ent", "<e1>", "and", "5-HT", "were", "competitively", "antagonized", "by", "the", "5-HT2", "antagonist", "C0022616#ent", "<e2>", ",", "with", "pKB", "values", "of", "8.81", "+", "/-", "0.11", "and", "8.83", "+", "/-", "0.10", "respectively", "."], "h": {"id": "C0700481", "name": "C0700481#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022616", "name": "C0022616#ent", "pos": [15, 16]}}
{"token": ["In", "this", "preparation", "mecamylamine", "block", "of", "C1839729#ent", "<e1>", "was", "accompanied", "by", "a", "use-dependent", "block", "relief", "induced", "by", "membrane", "depolarization", "with", "the", "activation", "of", "C1839729#ent", "<e1>", "by", "endogenous", "C0242894#ent", "<e1>", "ACh", ")", "."], "h": {"id": "C1839729", "name": "C1839729#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242894", "name": "C0242894#ent", "pos": [27, 28]}}
{"token": ["The", "C0014442#ent", "<e1>", "in", "the", "C1417453#ent", "<e2>", "lines", "required", "higher", "levels", "of", "tryptophan", "for", "feedback", "inhibition", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417453", "name": "C1417453#ent", "pos": [5, 6]}}
{"token": ["Taken", "together", ",", "this", "murine", "C4082486#ent", "<e1>", "model", "identifies", "CXCR3", "as", "C1539893#ent", "<e2>", "indicates", "that", "inflammatory", "glial", "responses", "act", "in", "concert", "with", "PrP(Sc", ")", "in", "disease", "development"], "h": {"id": "C4082486", "name": "C4082486#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539893", "name": "C1539893#ent", "pos": [11, 12]}}
{"token": ["As", "the", "sole", "site", "of", "nucleocytoplasmic", "communication", ",", "the", "C1136365#ent", "<e1>", "nuclear", "pore", "complex", "such", "as", "NUP98", ",", "NUP88", ",", "C1704852#ent", "<e2>", "were", "also", "deregulated", "in", "Jurkat", "cells"], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704852", "name": "C1704852#ent", "pos": [20, 21]}}
{"token": ["The", "gene", "for", "tumor", "necrosis", "factor-alpha", "C0812246#ent", "<e1>", ")", "is", "encoded", "in", "the", "MHC", "locus", "and", "C0812246#ent", "<e1>", "is", "involved", "in", "the", "pathogenesis", "of", "C1419798#ent", "<e1>", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419798", "name": "C1419798#ent", "pos": [24, 25]}}
{"token": ["Unlike", "the", "C1423108#ent", "<e1>", "from", "yeast", "nucleus", "which", "is", "specific", "for", "C1705556#ent", "<e2>", ",", "E.coli", "PAP", "I", "use", "all", "four", "nucleotide", "triphosphates", "substrates", "for", "addition", "of", "long", "ribohomopolymers", "to", "RNA", "."], "h": {"id": "C1423108", "name": "C1423108#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [11, 12]}}
{"token": ["Evolution", "of", "the", "PB1", "and", "PB2", "genes", "is", "less", "correlated", "with", "host-specific", "factors", "and", "their", "C0086376#ent", "<e1>", "appear", "to", "be", "evolving", "more", "slowly", "than", "NP", "and", "C1418225#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418225", "name": "C1418225#ent", "pos": [26, 27]}}
{"token": ["The", "C0012906#ent", "<e1>", "an", "absolute", "requirement", "for", "C1417500#ent", "<e2>", "+", "and", "is", "stimulated", "by", "AdoMet", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [7, 8]}}
{"token": ["The", "dynamics", "of", "the", "complex", "formation", "between", "pyridoxal", "5'-phosphate", "C1335272#ent", "<e1>", ")", "and", "histidine", "in", "the", "presence", "of", "C1415505#ent", "<e2>", "examined", "."], "h": {"id": "C1335272", "name": "C1335272#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415505", "name": "C1415505#ent", "pos": [18, 19]}}
{"token": ["The", "cell", "surface", "hyaluronan", "receptor", "C1332712#ent", "<e1>", ",", "two", "hyaluronidases", ",", "C1577331#ent", "<e2>", "and", "Hyal-2", ",", "and", "two", "lysosomal", "enzymes", "beta-glucuronidase", "and", "beta-N-acetylglucosaminidase", ",", "are", "involved", "."], "h": {"id": "C1332712", "name": "C1332712#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1577331", "name": "C1577331#ent", "pos": [11, 12]}}
{"token": ["CEM15", "is", "identical", "to", "C4255227#ent", "<e1>", "belongs", "to", "a", "family", "of", "C0086376#ent", "<e2>", "involved", "in", "RNA", "and", "DNA", "deamination"], "h": {"id": "C4255227", "name": "C4255227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["Experimental", "infusion", "of", "the", "cancer", "chemotherapeutic", "agents", "cisplatin", "and", "C0079083#ent", "<e1>", "and", "the", "C1136254#ent", "<e2>", "doxycycline", "are", "reported", "herein", "."], "h": {"id": "C0079083", "name": "C0079083#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [13, 14]}}
{"token": ["The", "monomeric", "and", "C1417215#ent", "<e1>", "forms", "of", "the", "C0027203#ent", "<e2>", "are", "similar", "in", "their", "catalytic", "activities"], "h": {"id": "C1417215", "name": "C1417215#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["Acidification", "is", "not", "a", "primary", "cause", "of", "C0268494#ent", "<e1>", "during", "regular", "C3811816#ent", "<e2>", "storage", "."], "h": {"id": "C0268494", "name": "C0268494#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811816", "name": "C3811816#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "show", "that", "activation", "of", "C0031667#ent", "<e1>", "subsequent", "metabolism", "of", "arachidonic", "acid", "the", "COX-2", "and", "LOX", "pathways", "C1705516#ent", "<e2>", "contribute", "to", "cyanide-induced", "ROS", "production", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705516", "name": "C1705516#ent", "pos": [18, 19]}}
{"token": ["Typical", "genes", "including", "transfer", "DNA", "T-DNA", ")", ",", "nopaline", "utilizing", "genes", ",", "trb", "genes", "C1335822#ent", "<e1>", ",", "rep", "genes", "tra", "genes", "acc", "and", "C0017376#ent", "<e2>", "assigned", "in", "this", "order", "to", "pTi-SAKURA", "."], "h": {"id": "C1335822", "name": "C1335822#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017376", "name": "C0017376#ent", "pos": [23, 24]}}
{"token": ["Use", "of", "the", "C0268314#ent", "<e1>", "produced", "a", "significant", "reduction", "in", "the", "time", "required", "for", "C1822653#ent", "<e2>", "division", "and", "in", "the", "charges", "to", "the", "patient", "."], "h": {"id": "C0268314", "name": "C0268314#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1822653", "name": "C1822653#ent", "pos": [14, 15]}}
{"token": ["We", "examined", "the", "possibility", "that", ",", "in", "sympathetic", "ganglia", "stress-induced", "C1825375#ent", "<e1>", "may", "be", "responsible", "for", "the", "expression", "of", "C0235222#ent", "<e2>"], "h": {"id": "C1825375", "name": "C1825375#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0235222", "name": "C0235222#ent", "pos": [19, 20]}}
{"token": ["On", "the", "other", "hand", ",", "C0340861#ent", "<e1>", "rapidly", "stimulated", "translocation", "of", "C1566790#ent", "<e2>", "into", "the", "nucleus", "in", "both", "cell", "types"], "h": {"id": "C0340861", "name": "C0340861#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [11, 12]}}
{"token": ["Based", "on", "our", "survey", "of", "the", "C0017366#ent", "<e1>", "we", "selected", "enoyl-acyl", "carrier", "protein", "reductase", "C1413979#ent", "<e2>", ")", "as", "a", "promising", "candidate", "for", "virtual", "screening", "inhibitor", "discovery", "."], "h": {"id": "C0017366", "name": "C0017366#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413979", "name": "C1413979#ent", "pos": [14, 15]}}
{"token": ["Primary", "sclerosing", "cholangitis", "described", "in", "a", "19-year-old", "woman", "suffering", "from", "undifferentiated", "autoimmune", "disease", "C0151859#ent", "<e1>", ",", "monarthritis", ",", "positive", "anti-nuclear", "antibodies", "anti-myeloperoxidase", "antibodies", "Coombs-test-positive", "anaemia", "and", "C0271623#ent", "<e2>"], "h": {"id": "C0151859", "name": "C0151859#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [26, 27]}}
{"token": ["Data", "on", "relative", "safety", "suggest", "that", "C0008287#ent", "<e1>", "is", "the", "most", "toxic", "C0038766#ent", "<e2>", "but", "glyburide", "causes", "dangerous", "hypoglycemia", "as", "often", "as", "C0008287#ent", "<e1>", "."], "h": {"id": "C0008287", "name": "C0008287#ent", "pos": [6, 7]}, "relation": "has_chemical_structure", "t": {"id": "C0038766", "name": "C0038766#ent", "pos": [12, 13]}}
{"token": ["The", "genes", "coding", "for", "C3272408#ent", "<e1>", "and", "DP2", ",", "the", "subunits", "of", "this", "C0012892#ent", "<e2>", "are", "highly", "conserved", "in", "the", "Euryarchaeota", "."], "h": {"id": "C3272408", "name": "C3272408#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012892", "name": "C0012892#ent", "pos": [13, 14]}}
{"token": ["We", "report", "successful", "treatment", "of", "paroxysmal", "dystonia", "C0270844#ent", "<e1>", "in", "three", "patients", "with", "central", "demyelinating", "disease", "C2698602#ent", "<e2>", ")", "using", "acetazolamide", "alone", "or", "in", "combination", "with", "carbamazepine", "."], "h": {"id": "C0270844", "name": "C0270844#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2698602", "name": "C2698602#ent", "pos": [16, 17]}}
{"token": ["Several", "very", "selective", "C0595726#ent", "<e1>", "and", "a", "C0235480#ent", "<e2>", "inhibitor", ",", "suitable", "for", "in", "vivo", ",", "have", "been", "tested", "for", "their", "effects", "on", "hyperbaric", "oxygen", "toxicity"], "h": {"id": "C0595726", "name": "C0595726#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [7, 8]}}
{"token": ["By", "the", "affinity", "chromatography/mass-spectrometry", "approach", "and", "the", "yeast", "two-hybrid", "screening", ",", "we", "identified", "Misshapen/NIKs-related", "kinase", "(", "MINK", ")", "as", "a", "novel", "C1854259#ent", "<e1>", "does", "not", "interact", "with", "Rap1", "or", "C0034678#ent", "<e2>", "."], "h": {"id": "C1854259", "name": "C1854259#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [29, 30]}}
{"token": ["C0005578#ent", "<e1>", "was", "discontinued", "in", "33", "patients", "with", "or", "without", "C0030567#ent", "<e2>", "and", "commenced", "in", "15", "patients", "with", "C0030567#ent", "<e2>", "."], "h": {"id": "C0005578", "name": "C0005578#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0030567", "name": "C0030567#ent", "pos": [10, 11]}}
{"token": ["High", "levels", "of", "expression", "were", "not", "accompanied", "by", "either", "amplification", "or", "rearrangements", "of", "the", "C0879468#ent", "<e1>", "AML", "cell", "C0011522#ent", "<e2>", "."], "h": {"id": "C0879468", "name": "C0879468#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [18, 19]}}
{"token": ["Here", "we", "show", "that", "a", "mammalian", "homolog", "of", "C4284306#ent", "<e1>", ",", "Apaf-1", ",", "can", "associate", "with", "several", "death", "proteases", "including", "C1705062#ent", "<e2>", ",", "caspase-8", ",", "caspase-9", ",", "and", "nematode", "CED-3", "in", "mammalian", "cells"], "h": {"id": "C4284306", "name": "C4284306#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705062", "name": "C1705062#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "we", "demonstrate", "that", "the", "C1423091#ent", "<e1>", "specifically", "regulated", "by", "C4049727#ent", "<e2>", ",", "and", "suggest", "this", "to", "be", "a", "contributory", "factor", "in", "the", "tissue-specific", "distribution", "of", "GPR10", "in", "vivo"], "h": {"id": "C1423091", "name": "C1423091#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4049727", "name": "C4049727#ent", "pos": [12, 13]}}
{"token": ["Cytochromes", "P450", "P450s", ")", "and", "glutathione", "S-transferases", "C1865138#ent", "<e1>", ")", "constitute", "two", "important", "C0014442#ent", "<e2>", "families", "involved", "in", "carcinogen", "metabolism", "."], "h": {"id": "C1865138", "name": "C1865138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [13, 14]}}
{"token": ["A", "key", "step", "in", "the", "processing", "of", "the", "C0021699#ent", "<e1>", "APP", ",", "or", "Amyloid", "Precursor", "Protein", "through", "the", "proteolytic", "cleavage", "the", "C3811065#ent", "<e2>", "BACE", ")", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C3811065", "name": "C3811065#ent", "pos": [21, 22]}}
{"token": ["C0021699#ent", "<e1>", "visualized", "as", "intramembrane", "particles", "(", "IMP", ";", "also", "called", "C3811065#ent", "<e2>", "at", "the", "cleaved", "surfaces", "of", "freeze-fractured", "plasma", "membranes", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [0, 1]}, "relation": "is_chemical_classification_of_gene_product", "t": {"id": "C3811065", "name": "C3811065#ent", "pos": [11, 12]}}
{"token": ["The", "amount", "of", "retinol", "bound", "to", "C1708152#ent", "<e1>", "increases", "when", "the", "C0235267#ent", "<e2>", "are", "illuminated", "."], "h": {"id": "C1708152", "name": "C1708152#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [11, 12]}}
{"token": ["Cyclooxygenase-2", "(", "C1565860#ent", "<e1>", ")", "gene", "and", "C1412356#ent", "<e2>", "(", "12-LO", ")", "gene", "are", "preferentially", "expressed", "over", "other", "types", "of", "cyclooxygenase", "and", "lipoxygenase", "in", "pancreatic", "beta-cells"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412356", "name": "C1412356#ent", "pos": [7, 8]}}
{"token": ["Microarray", "analysis", "semiquantitative", "and", "quantitative", "reverse", "transcriptase", "polymerase", "chain", "reaction", "SF", "PMN", "from", "patients", "with", "C0002893#ent", "<e1>", "as", "a", "novel", "source", "for", "C1332681#ent", "<e2>", "in", "diseased", "joints", "."], "h": {"id": "C0002893", "name": "C0002893#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332681", "name": "C1332681#ent", "pos": [22, 23]}}
{"token": ["In", "comparison", ",", "recruited", "SF", "PMN", "from", "patients", "with", "C0002893#ent", "<e1>", "were", "sensitized", "for", "C1332681#ent", "<e2>", "production", ",", "because", "IL-10", "alone", "was", "sufficient", "to", "induce", "C1332681#ent", "<e2>", "release", "."], "h": {"id": "C0002893", "name": "C0002893#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332681", "name": "C1332681#ent", "pos": [14, 15]}}
{"token": ["Extraction", "of", "intestinal", "membranes", "C0146953#ent", "<e1>", "their", "treatment", "with", "C0043376#ent", "<e2>", "indicated", "that", "the", "protein", "is", "an", "integral", "membrane", "glycoprotein", "apparent", "molecular", "weight", "kDa", "by", "sodium", "dodecyl", "sulfate", "polyacrylamide", "gel", "electrophoresis", "SDS-PAGE", ")", "."], "h": {"id": "C0146953", "name": "C0146953#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0043376", "name": "C0043376#ent", "pos": [9, 10]}}
{"token": ["The", "indications", "(", "usually", "multiple", ")", "for", "VS", "in", "C1868117#ent", "<e1>", "patients", "were", "C0032290#ent", "<e2>", "poor", "ventilation", "of", "mucous", "plugging", "mechanical", "failure", "and", "airway", "control/protection", "for", "seizures", "and", "coma", "."], "h": {"id": "C1868117", "name": "C1868117#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032290", "name": "C0032290#ent", "pos": [13, 14]}}
{"token": ["Both", "ERalpha", "C2987634#ent", "<e1>", "and", "ERalpha", "C2987634#ent", "<e1>", "enhanced", "C1706005#ent", "<e1>", "production", "of", "mouse", "splenocytes", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [9, 10]}}
{"token": ["HLA-DRB1", ",", "HLA-DQB1", ",", "and", "C0919430#ent", "<e1>", "VDR", ")", "polymorphisms", "were", "previously", "associated", "with", "C0041323#ent", "<e2>", "(", "TB", ")", "and", "are", "here", "investigated", "as", "candidates", "for", "TB", "susceptibility", "in", "the", "Venda", "population", "South", "Africa"], "h": {"id": "C0919430", "name": "C0919430#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [14, 15]}}
{"token": ["AS-3201", "[", "(3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetrone", "]", "is", "a", "structurally", "novel", "and", "stereospecifically", "potent", "aldose", "reductase", "AKR1B", ";", "C1456345#ent", "<e1>", "inhibitor", ",", "which", "contains", "a", "succinimide", "ring", "undergoes", "C0018293#ent", "<e2>", "at", "physiological", "pH", "levels", "."], "h": {"id": "C1456345", "name": "C1456345#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0018293", "name": "C0018293#ent", "pos": [25, 26]}}
{"token": ["With", "exception", "of", "C0004134#ent", "<e1>", "and", "myoclonus", ",", "C0026650#ent", "<e2>", "not", "typical", "features", "of", "POLG1", "associated", "disorders"], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [8, 9]}}
{"token": ["This", "C0014442#ent", "<e1>", "also", "catalyzed", "the", "transesterification", "of", "C0068006#ent", "<e2>", "into", "octadecylphosphoglycerol", "or", "octadecylphosphoethanolamine", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0068006", "name": "C0068006#ent", "pos": [8, 9]}}
{"token": ["The", "effects", "of", "C0110270#ent", "<e1>", "(", "N-[(6-methyl-5-oxo-3-thiomorpholinyl", ")", "carbonyl]-L-histidyl-L-prolinamide", ")", ",", "a", "novel", "C1421143#ent", "<e2>", "were", "investigated", "on", "absence-like", "seizure", "tonic", "convulsion", "the", "spontaneously", "epileptic", "rat", "SER", ")", ",", "which", "is", "a", "genetically", "defined", "double-mutant", "."], "h": {"id": "C0110270", "name": "C0110270#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [13, 14]}}
{"token": ["Neonatal", "lupus", "is", "a", "C0039082#ent", "<e1>", "characterized", "by", "C0746306#ent", "<e2>", "congenital", "heart", "block", "CHB", ")", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0746306", "name": "C0746306#ent", "pos": [8, 9]}}
{"token": ["C1413309#ent", "<e1>", "with", "mammalian", "ovine", "C0022661#ent", "<e2>", "and", "rat/human", "C0022661#ent", "<e2>", "was", "negligible", "."], "h": {"id": "C1413309", "name": "C1413309#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [5, 6]}}
{"token": ["Accordingly", ",", "the", "inhibitory", "potential", "of", "pranlukast", "was", "evaluated", "and", "compared", "with", "that", "of", "C0378466#ent", "<e1>", ",", "a", "known", "C1828473#ent", "<e2>", "in", "in", "vitro", "microsomal", "incubation", "studies", "."], "h": {"id": "C0378466", "name": "C0378466#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1828473", "name": "C1828473#ent", "pos": [19, 20]}}
{"token": ["Other", "regions", "are", "inhibited", "from", "forming", "clouds", "because", "of", "C0058836#ent", "<e1>", "transports", "of", "C0067320#ent", "<e2>", "and", "strong", "subsidence", "."], "h": {"id": "C0058836", "name": "C0058836#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0067320", "name": "C0067320#ent", "pos": [13, 14]}}
{"token": ["Adenoviral", "infection", "found", "to", "prevail", "among", "non-influenza", "infections", "the", "Ukraine", ",", "C0035235#ent", "<e1>", "the", "north", "of", "the", "Russian", "Federation", "in", "the", "Far", "East", "C0042769#ent", "<e2>", "by", "Echo", "and", "Coxsackievirus", "B", "the", "Urals", "and", "Byelarus", "Republic", "."], "h": {"id": "C0035235", "name": "C0035235#ent", "pos": [11, 12]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [23, 24]}}
{"token": ["C1142183#ent", "<e1>", "mammalian", "hosts", "through", "insect", "vectors", "cause", "economically", "important", "C0012634#ent", "<e2>", "of", "domesticated", "animals", "."], "h": {"id": "C1142183", "name": "C1142183#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [10, 11]}}
{"token": ["The", "method", "is", "based", "on", "the", "simultaneous", "separation", "of", "lipids", "on", "high-performance", "thin-layer", "chromatography", "plates", "followed", "by", "a", "microassay", "for", "phosphorus", "of", "PI", "C0848332#ent", "<e1>", "and", "a", "densitometric", "assay", "of", "DPI", "and", "C3541335#ent", "<e2>", "."], "h": {"id": "C0848332", "name": "C0848332#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3541335", "name": "C3541335#ent", "pos": [32, 33]}}
{"token": ["Two", "major", "C0848332#ent", "<e1>", "were", "identified", "as", "human", "triosephosphate", "isomerase", "C3541335#ent", "<e2>", ")", "by", "MALDI-TOF", "mass", "spectrometry"], "h": {"id": "C0848332", "name": "C0848332#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541335", "name": "C3541335#ent", "pos": [10, 11]}}
{"token": ["Slight", "increases", "in", "susceptibility", "were", "observed", "with", "Pseudomonas", "aeruginosa", "cefotaxime", "and", "moxalactam", "and", "for", "C1456246#ent", "<e1>", "cefoxitin", "and", "C1707322#ent", "<e2>", "."], "h": {"id": "C1456246", "name": "C1456246#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1707322", "name": "C1707322#ent", "pos": [18, 19]}}
{"token": ["Statistical", "analysis", "strain-dependent", "expression", "of", "serine/threonine", "protein", "phosphatase", "1", "serine/threonine", "protein", "phosphatase", "2A", "large", "GTP", "binding", "protein", "C1537677#ent", "<e1>", ",", "guanine", "nucleotide-binding", "protein", "beta", "putative", "GTP-binding", "protein", "Ran", "receptor", "of", "activated", "protein", "kinase", "C1", "WASP-family", "protein", "member", "1", "C1336931#ent", "<e2>", "14", "-", "3", "-", "3", "protein", "gamma"], "h": {"id": "C1537677", "name": "C1537677#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1336931", "name": "C1336931#ent", "pos": [38, 39]}}
{"token": ["The", "reduction", "of", "the", "carotid", "sinus", "reflex", "the", "cat", "is", "more", "distinct", "after", "WA", "335", "than", "after", "C0071069#ent", "<e1>", "and", "corresponds", "to", "that", "produced", "by", "C0010620#ent", "<e2>", "."], "h": {"id": "C0071069", "name": "C0071069#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010620", "name": "C0010620#ent", "pos": [25, 26]}}
{"token": ["These", "findings", "suggest", "that", "higher", "C1567299#ent", "<e1>", "amplitudes", "associated", "with", "medication", "probably", "reflected", "improved", "C0310298#ent", "<e2>", "performance", "with", "medication", ",", "rather", "than", "a", "direct", "action", "of", "the", "drugs", "on", "C1567299#ent", "<e1>", "."], "h": {"id": "C1567299", "name": "C1567299#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0310298", "name": "C0310298#ent", "pos": [14, 15]}}
{"token": ["They", "are", "the", "colony-stimulating", "factor-1", "CSF1", ")", "and", "Steel", "factor", "SLF", ")", "receptors", ",", "encoded", "by", "the", "C0016053#ent", "<e1>", "and", "KIT", "C1417123#ent", "<e2>", ",", "respectively", ",", "and", "the", "product", "of", "the", "FLT3/FLK2", "gene", "."], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [21, 22]}}
{"token": ["Benzothiadiazines", ",", "potent", "oral", "diuretics", ",", "also", "inhibit", "C1413038#ent", "<e1>", "although", "to", "a", "lesser", "degree", "than", "acetazolamide", "(", "C0591362#ent", "<e2>", ")", "."], "h": {"id": "C1413038", "name": "C1413038#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0591362", "name": "C0591362#ent", "pos": [18, 19]}}
{"token": ["CO2", "diffusing", "capacities", "DmCO2", ")", "were", "measured", "at", "22", "degrees", "C", "on", "12", "isolated", "perfused", "dog", "lung", "lobes", "and", "after", "inhibition", "of", "lung", "tissue", "C1413038#ent", "<e1>", "CA", ")", "by", "acetazolamide", "(", "C0591362#ent", "<e2>", ")", "."], "h": {"id": "C1413038", "name": "C1413038#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0591362", "name": "C0591362#ent", "pos": [31, 32]}}
{"token": ["In", "this", "study", "we", "screened", "the", "C0671924#ent", "<e1>", "CBP", "and", "C3887789#ent", "<e2>", "for", "mutations", "in", "human", "epithelial", "cancer", "cell", "lines", "primary", "tumours"], "h": {"id": "C0671924", "name": "C0671924#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3887789", "name": "C3887789#ent", "pos": [10, 11]}}
{"token": ["The", "C1420603#ent", "<e1>", "binding", "site", "be", "bound", "by", "and", "respond", "to", "C2699748#ent", "<e2>"], "h": {"id": "C1420603", "name": "C1420603#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2699748", "name": "C2699748#ent", "pos": [11, 12]}}
{"token": ["In", "several", "tissues", ",", "SNAIL", "(", "C2984121#ent", "<e1>", ")", "and", "SLUG", "(", "SNAI2", ")", "induce", "epithelial-mesenchymal", "transition", "C2712370#ent", "<e2>", "target", "gene", "transcription", "including", "CDH1", "repression", ",", "but", "these", "transcription", "factors", "not", "been", "studied", "in", "thyroid", "carcinoma"], "h": {"id": "C2984121", "name": "C2984121#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [17, 18]}}
{"token": ["Oocytes", "were", "injected", "with", "cRNA", "for", "the", "C3529801#ent", "<e1>", "mouse", "to", "express", "homomeric", "receptors", "with", "C1419007#ent", "<e2>", "combination", "with", "either", "epsilon", "1", "epsilon", "2", "epsilon", "3", "epsilon", "4", "subunits", "to", "express", "heteromeric", "receptors"], "h": {"id": "C3529801", "name": "C3529801#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419007", "name": "C1419007#ent", "pos": [15, 16]}}
{"token": ["Synthetic", "analogs", "and", "homologs", "of", "G1", "and", "C1422272#ent", "<e1>", "were", "all", "shown", "to", "be", "C0003364#ent", "<e2>", "low-mild", "potency", ",", "not", "affecting", "appreciably", "cardiac", "inotropism", "breathing", "."], "h": {"id": "C1422272", "name": "C1422272#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [14, 15]}}
{"token": ["We", "report", "on", "a", "case", "of", "C0008732#ent", "<e1>", "the", "operation", "of", "a", "C0741160#ent", "<e2>"], "h": {"id": "C0008732", "name": "C0008732#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0741160", "name": "C0741160#ent", "pos": [12, 13]}}
{"token": ["Elevated", "plasma", "C1412471#ent", "<e1>", "is", "an", "independent", "risk", "factor", "C0010054#ent", "<e2>"], "h": {"id": "C1412471", "name": "C1412471#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [9, 10]}}
{"token": ["In", "this", "study", ",", "six", "polymorphic", "sites", "the", "C1412471#ent", "<e1>", "anlaysed", "in", "235", "patients", "with", "C0010054#ent", "<e2>", "CAD", ")", "and", "216", "normal", "control", "."], "h": {"id": "C1412471", "name": "C1412471#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [15, 16]}}
{"token": ["In", "PT", "cells", "activation", "of", "the", "C1366882#ent", "<e1>", "pathway", "by", "insulin-like", "growth", "factor", "I", "C1334089#ent", "<e2>", ")", "increased", "survival", "by", "threefold", "(", "P", "<", "0.001", ")", ",", "and", "this", "IGF-I-enhanced", "cell", "survival", "inhibited", "by", "PD-098059", "."], "h": {"id": "C1366882", "name": "C1366882#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [14, 15]}}
{"token": ["In", "humans", ",", "there", "are", "only", "two", "known", "C1417635#ent", "<e1>", "or", "cobalamin-dependent", "enzymes", ":", "C0039676#ent", "<e2>", "methylmalonyl-CoA", "mutase"], "h": {"id": "C1417635", "name": "C1417635#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0039676", "name": "C0039676#ent", "pos": [14, 15]}}
{"token": ["Neurological", "deficit", "more", "frequently", "in", "C0003869#ent", "<e1>", "than", "in", "C0041296#ent", "<e2>", "79", "%", "vs", "59", "%", ")", ",", "while", "bowel", "bladder", "involvement", "was", "more", "commonly", "found", "in", "tuberculous", "spondylitis"], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [9, 10]}}
{"token": ["Fever", "was", "more", "frequent", "in", "patients", "with", "C0003869#ent", "<e1>", "etiology", "than", "in", "those", "with", "C0041296#ent", "<e2>", "SIS", "(", "p", "=", "0.004", ")", "."], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [14, 15]}}
{"token": ["Elevated", "levels", "of", "drug-induced", "DSBs", "in", "leukemia", "cells", "associated", "with", "activity", "of", "C0031727#ent", "<e1>", "and", "enhanced", "phosphorylation", "of", "C1415406#ent", "<e2>", "serine", "139", "(", "gamma-H2AX", ")", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415406", "name": "C1415406#ent", "pos": [18, 19]}}
{"token": ["Most", "babies", "who", "now", "develop", "C0746102#ent", "<e1>", "a", "birth", "weight", "1000", "g", "and", "have", "only", "mild", "early", "C0035242#ent", "<e2>", "requiring", "minimal", "ventilation", "and", "low", "concentrations", "of", "inspired", "oxygen"], "h": {"id": "C0746102", "name": "C0746102#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [17, 18]}}
{"token": ["C0746102#ent", "<e1>", "prematurity", "(", "CLD", ")", "is", "a", "common", "C0035242#ent", "<e2>", "preterm", "infants"], "h": {"id": "C0746102", "name": "C0746102#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [9, 10]}}
{"token": ["We", "have", "studied", "the", "C0812382#ent", "<e1>", "properties", "of", "a", "NUCKS-derived", ",", "synthetic", "peptide", "an", "extended", "C1706574#ent", "<e2>", "motif", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706574", "name": "C1706574#ent", "pos": [15, 16]}}
{"token": ["The", "observed", "decrease", "of", "blood", "lead", "C0031381#ent", "<e1>", "levels", "over", "time", "is", "a", "consequence", "of", "C1335208#ent", "<e2>", "restriction", "."], "h": {"id": "C0031381", "name": "C0031381#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335208", "name": "C1335208#ent", "pos": [15, 16]}}
{"token": ["They", "also", "suggest", "that", "C1417951#ent", "<e1>", "is", "a", "candidate", "C0079429#ent", "<e2>", "for", "diabetes", "mellitus", "humans", "."], "h": {"id": "C1417951", "name": "C1417951#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [9, 10]}}
{"token": ["Although", "the", "subject", "was", "found", "to", "be", "homozygous", "for", "C4264458#ent", "<e1>", "genetic", "findings", "not", "significant", "for", "a", "number", "of", "other", "C1142644#ent", "<e2>", "and", "CYP3A5", "allelic", "variants", "."], "h": {"id": "C4264458", "name": "C4264458#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1142644", "name": "C1142644#ent", "pos": [20, 21]}}
{"token": ["We", "chose", "C0011516#ent", "<e1>", "EcoRV", "from", "E.", "coli", "model", "proteins", "despite", "the", "observation", "that", "C0221406#ent", "<e2>", "can", "result", "in", "a", "toxic", "effect", "the", "cells", "."], "h": {"id": "C0011516", "name": "C0011516#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [14, 15]}}
{"token": ["Tissue", "inhibitor", "C0025543#ent", "<e1>", "(", "TIMP-3", ")", "is", "a", "natural", "inhibitor", "C1334706#ent", "<e2>", "involved", "in", "matrix", "degradation", "ectodomain", "shedding", "of", "many", "cell-surface", "proteins", "including", "death", "receptors", "their", "ligands", "."], "h": {"id": "C0025543", "name": "C0025543#ent", "pos": [2, 3]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "a", "possibility", "that", "C0033634#ent", "<e1>", "potentiate", "AA", "liberation", "through", "a", "C0120465#ent", "<e2>", "protein-mediated", "mechanism", "in", "saponin-permeabilized", "rabbit", "platelets", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "H2", "but", "not", "C1136312#ent", "<e1>", "the", "histamine-induced", "cyclic", "AMP", "elevation", ",", "suggesting", "histamine", "activates", "C1382029#ent", "<e2>", "an", "H2", "receptor"], "h": {"id": "C1136312", "name": "C1136312#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [17, 18]}}
{"token": ["The", "mitogenic", "effect", "mox-LDL", "may", "be", "mediated", "via", "its", "oxidation", "products", "C1418392#ent", "<e1>", ",", "H2O2", "(", "reactive", "oxygen", "species", "donor", ")", ",", "and", "C1414369#ent", "<e2>", "."], "h": {"id": "C1418392", "name": "C1418392#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414369", "name": "C1414369#ent", "pos": [23, 24]}}
{"token": ["The", "defect", "in", "C1420708#ent", "<e1>", "gene", "expression", "selective", "since", "C1334114#ent", "<e2>", "expression", "was", "induced", "in", "T-TIL", "."], "h": {"id": "C1420708", "name": "C1420708#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334114", "name": "C1334114#ent", "pos": [9, 10]}}
{"token": ["These", "complications", "can", "occur", "under", "C0360105#ent", "<e1>", "alone", "and", "in", "combination", "with", "C0003280#ent", "<e2>", "whereas", "the", "coagulation", "parameters", "can", "remain", "unchanged", "."], "h": {"id": "C0360105", "name": "C0360105#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [12, 13]}}
{"token": ["The", "skin", "lesions", "leukocytopenia", "rapidly", "disappeared", "on", "discontinuation", "of", "the", "C0013227#ent", "<e1>", ",", "while", "the", "C0003862#ent", "<e2>", "continued", "for", "weeks", "or", "months", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [15, 16]}}
{"token": ["The", "C1538314#ent", "<e1>", "to", "which", "C1333706#ent", "<e2>", "binds", "include", "the", "insulin", "receptor", "IR", ")", ",", "the", "fibroblast", "growth", "factor", "receptor", "FGFR", ")", ",", "the", "platelet-derived", "growth", "factor", "receptor", "PDGFR", ")", ",", "and", "the", "tunica", "endothelial", "kinase", "Tek/Tie2", ")", "receptor", "."], "h": {"id": "C1538314", "name": "C1538314#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1333706", "name": "C1333706#ent", "pos": [5, 6]}}
{"token": ["The", "study", "shows", "that", "the", "device", "can", "detect", "frequent", "(", "AF4", ",", "AF6", ",", "AF10", ",", "ELL", "or", "C1334513#ent", "<e1>", ")", "as", "well", "as", "rare", "partner", "genes", "AF17", ",", "C1418891#ent", "<e2>", ")", "."], "h": {"id": "C1334513", "name": "C1334513#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1418891", "name": "C1418891#ent", "pos": [29, 30]}}
{"token": ["Peptide", "fragments", "L-phenylalanine", ",", "and", "C0053355#ent", "<e1>", "(", "an", "aminopeptidase", "inhibitor", "did", "not", "interfere", "with", "C1708407#ent", "<e2>", "uptake", "."], "h": {"id": "C0053355", "name": "C0053355#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1708407", "name": "C1708407#ent", "pos": [15, 16]}}
{"token": ["C1858663#ent", "<e1>", "recruits", "mSin3", "and", "its", "associated", "C0019643#ent", "<e2>", "2", ";", "C1858663#ent", "<e1>", "also", "competes", "with", "p300", "for", "binding", "to", "MEF2", "."], "h": {"id": "C1858663", "name": "C1858663#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019643", "name": "C0019643#ent", "pos": [7, 8]}}
{"token": ["Previously", "reported", "proteins", "in", "the", "ALK", "signal", "pathway", "identified", "including", "PI3-K", ",", "Jak2", ",", "Jak3", ",", "C1367307#ent", "<e1>", ",", "Grb2", ",", "IRS", ",", "and", "C1418640#ent", "<e2>", "."], "h": {"id": "C1367307", "name": "C1367307#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418640", "name": "C1418640#ent", "pos": [24, 25]}}
{"token": ["These", "results", "suggest", "that", "continuous", "intravenous", "infusion", "of", "C0060180#ent", "<e1>", "is", "safe", "and", "produces", "favorable", "hemodynamic", "responses", "in", "severe", "C0018801#ent", "<e2>"], "h": {"id": "C0060180", "name": "C0060180#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["Electrostatic", "potentials", "C1332694#ent", "<e1>", "C1412756#ent", "<e2>", "and", "B1", "show", "that", "anionic", "regions", "of", "C1332694#ent", "<e1>", "C1412756#ent", "<e2>", "enable", "them", "to", "bind", "peptides", "while", "cationic", "regions", "at", "homologous", "locations", "cyclin", "B1", "binding", "."], "h": {"id": "C1332694", "name": "C1332694#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412756", "name": "C1412756#ent", "pos": [4, 5]}}
{"token": ["We", "propose", "that", "C2987024#ent", "<e1>", "is", "an", "excellent", "candidate", "for", "as", "yet", "unmapped", "C2931187#ent", "<e2>", "man", "and", "animals", "."], "h": {"id": "C2987024", "name": "C2987024#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2931187", "name": "C2931187#ent", "pos": [13, 14]}}
{"token": ["These", "results", "demonstrate", "that", "combining", "multicopies", "or", "single", "copies", "of", "C0030956#ent", "<e1>", "with", "hinge", "fragment", "human", "IgG", "and", "C0030953#ent", "<e2>", "measles", "virus", "protein", "induce", "anti-peptide", "immune", "responses"], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030953", "name": "C0030953#ent", "pos": [18, 19]}}
{"token": ["Response", "variability", "to", "C0085826#ent", "<e1>", "been", "described", "and", "the", "widespread", "use", "of", "acetylsalicylic", "acid", "C0007804#ent", "<e2>", ")", "and", "clopidogrel", "requires", "clarification", "of", "the", "residual", "platelet", "reactivity", "RPR", ")", "."], "h": {"id": "C0085826", "name": "C0085826#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [14, 15]}}
{"token": ["The", "newer", "C0085826#ent", "<e1>", ",", "however", ",", "are", "more", "expensive", "than", "C0007804#ent", "<e2>", ",", "and", "their", "cost-effectiveness", "is", "not", "easily", "estimated", "."], "h": {"id": "C0085826", "name": "C0085826#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [11, 12]}}
{"token": ["C0149521#ent", "<e1>", "a", "persistent", "C0029400#ent", "<e2>", "the", "pancreas", ",", "in", "which", "the", "digestive", "protease", "trypsin", "a", "fundamental", "pathogenetic", "role", "."], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029400", "name": "C0029400#ent", "pos": [4, 5]}}
{"token": ["Activation", "of", "the", "C1414313#ent", "<e1>", "antimicrobial", "concentrations", "of", "human", "C1539241#ent", "<e2>", "and", "increased", "the", "activity", "of", "organotypic", "epidermal", "cultures", "against", "Staphylococcus", "aureus"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539241", "name": "C1539241#ent", "pos": [9, 10]}}
{"token": ["In", "the", "second", "group", ",", "there", "were", "20", "subjects", "with", "C0525678#ent", "<e1>", "who", "were", "administered", "placebo", "(", "C0053409#ent", "<e2>", ")", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0053409", "name": "C0053409#ent", "pos": [17, 18]}}
{"token": ["CLSM", "demonstrated", "a", "colocalization", "of", "C1420744#ent", "<e1>", "and", "F-actin", "in", "control", "liver", "its", "deterioration", "in", "CBDL", "C0023899#ent", "<e2>", "."], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "analyze", "C0149751#ent", "<e1>", "lacked", "the", "histological", "features", "of", "C0302180#ent", "<e2>", "for", "human", "papillomavirus", "HPV", ")", "DNA", "."], "h": {"id": "C0149751", "name": "C0149751#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0302180", "name": "C0302180#ent", "pos": [15, 16]}}
{"token": ["The", "proteins", "that", "bear", "the", "O-GlcNAc", "modification", "are", "very", "diverse", ",", "including", "C0035680#ent", "<e1>", "many", "of", "its", "transcription", "factors", "numerous", "chromatin-associated", "proteins", "nuclear", "pore", "proteins", "C0694890#ent", "<e2>", ",", "tumor", "suppressors", "proteins", "involved", "in", "translation", "."], "h": {"id": "C0035680", "name": "C0035680#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [25, 26]}}
{"token": ["biliary", "fibrosis", "associated", "with", "Progamotaenia", "festiva", "fibrous", "peritonitis", "C0008033#ent", "<e1>", ",", "pericarditis", "and", "C0154652#ent", "<e2>", "to", "Breinlia", "mundayi"], "h": {"id": "C0008033", "name": "C0008033#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0154652", "name": "C0154652#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "examine", "whether", "C1710463#ent", "<e1>", "to", "the", "production", "of", "the", "developmental", "profiles", "C0029282#ent", "<e2>", "activity", "."], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [13, 14]}}
{"token": ["A", "relevant", "consequence", "of", "AICD", "defect", "is", "the", "demonstrated", "development", "of", "C2931071#ent", "<e1>", "IL-2", ",", "IL-2R", "alpha", "and", "IL-2R", "beta", "knockout", "mice", "but", "not", "in", "C1334119#ent", "<e2>", ",", "IL-7", ",", "or", "IL-7R", "knockout", "mice"], "h": {"id": "C2931071", "name": "C2931071#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334119", "name": "C1334119#ent", "pos": [25, 26]}}
{"token": ["C0030305#ent", "<e1>", "numerous", "unique", "challenges", "to", "the", "practicing", "C0017178#ent", "<e2>", "specialist", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0017178", "name": "C0017178#ent", "pos": [8, 9]}}
{"token": ["Administration", "of", "C2349086#ent", "<e1>", "inhibitors", "reduced", "the", "pathophysiological", "signs", "of", "C0024117#ent", "<e2>", "decreased", "the", "increased", "TGF-beta(1)", "and", "peribronchial", "fibrosis", "including", "phosphoinositide", "3-kinase", "PI3K", "activity", "after", "OVA", "inhalation", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [10, 11]}}
{"token": ["Patients", "with", "New", "York", "Heart", "Association", "class", "II", "C0018802#ent", "<e1>", "also", "receive", "a", "beta", "blocker", "metoprolol", ",", "C1815010#ent", "<e2>", "or", "bisoprolol", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C1815010", "name": "C1815010#ent", "pos": [17, 18]}}
{"token": ["The", "two", "groups", "did", "not", "differ", "statistically", "in", "the", "frequencies", "of", "C0002085#ent", "<e1>", "at", "the", "D3S1358", ",", "vWA", ",", "or", "C1414592#ent", "<e2>", "loci", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414592", "name": "C1414592#ent", "pos": [20, 21]}}
{"token": ["Total", "amounts", "CCNU", "and", "C0036637#ent", "<e1>", "hydroxylation", "with", "C0608437#ent", "<e2>", "twice", "that", "with", "hepatic", "microsomes", "Aroclor", "1254-treated", "rats", "."], "h": {"id": "C0036637", "name": "C0036637#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0608437", "name": "C0608437#ent", "pos": [8, 9]}}
{"token": ["Review", "of", "the", "literature", "disclosed", "that", "C0156221#ent", "<e1>", "seems", "to", "be", "not", "uncommon", "in", "C0393819#ent", "<e2>"], "h": {"id": "C0156221", "name": "C0156221#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0393819", "name": "C0393819#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "study", ",", "nicotine", "induced", "NE", "release", "in", "the", "C0002707#ent", "<e1>", "(", "AMYG", ")", "and", "the", "hippocampus", "(", "C1415692#ent", "<e2>", ")", "of", "the", "same", "rat", "in", "vivo"], "h": {"id": "C0002707", "name": "C0002707#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [20, 21]}}
{"token": ["Low-grade", "fever", "leukocytosis", "persisted", "and", "follow-up", "CT", "scanning", "ring", "enhancement", "the", "thalamic", "lesion", "C0014473#ent", "<e1>", "suggesting", "a", "C0006105#ent", "<e2>"], "h": {"id": "C0014473", "name": "C0014473#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006105", "name": "C0006105#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "sera", "from", "10", "patients", "with", "Addison's", "disease", "10", "patients", "with", "C0042900#ent", "<e1>", "(", "without", "associated", "C1705846#ent", "<e2>", ")", "were", "all", "negative", "for", "antibody", "reactivity", "to", "the", "symporter", "."], "h": {"id": "C0042900", "name": "C0042900#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705846", "name": "C1705846#ent", "pos": [18, 19]}}
{"token": ["C0030360#ent", "<e1>", "a", "rare", "C0019247#ent", "<e2>"], "h": {"id": "C0030360", "name": "C0030360#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [4, 5]}}
{"token": ["C0014964#ent", "<e1>", "is", "commonly", "used", "for", "the", "treatment", "of", "C0041296#ent", "<e2>", "and", "atypical", "mycobacterial", "infection"], "h": {"id": "C0014964", "name": "C0014964#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [9, 10]}}
{"token": ["In", "vitro", "screening", "assays", "developed", "in", "HepG2", "cells", "rat", "primary", "C0669372#ent", "<e1>", ",", "and", "rhesus", "monkey", "C0669372#ent", "<e1>", "using", "the", "fluorescent-labeled", "phospholipid", "probe", "N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine", "(", "C0067563#ent", "<e1>", ")", "or", "Nile", "Red", "lipid", "stain"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0067563", "name": "C0067563#ent", "pos": [25, 26]}}
{"token": ["We", "conclude", "that", "this", "boy", "'s", "illness", ",", "including", "the", "C0206061#ent", "<e1>", "represented", "a", "reaction", "to", "C0022625#ent", "<e2>", "which", "was", "dose-related", "rather", "than", "idiosyncratic", "."], "h": {"id": "C0206061", "name": "C0206061#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [16, 17]}}
{"token": ["In", "this", "report", ",", "we", "have", "characterized", "four", "members", "of", "the", "C1420603#ent", "<e1>", "the", "nematode", "C0949990#ent", "<e2>"], "h": {"id": "C1420603", "name": "C1420603#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0949990", "name": "C0949990#ent", "pos": [15, 16]}}
{"token": ["Together", ",", "the", "results", "reveal", "an", "unexpected", "mechanism", "of", "action", "for", "this", "unique", "C2266975#ent", "<e1>", "and", "suggest", "future", "development", "of", "this", "and", "similar", "C0991617#ent", "<e2>", "as", "antiangiogenesis", "and", "anticancer", "drugs"], "h": {"id": "C2266975", "name": "C2266975#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [23, 24]}}
{"token": ["These", "data", "suggest", "that", "C1332701#ent", "<e1>", "plays", "similar", ",", "but", "not", "identical", ",", "roles", "to", "C3814151#ent", "<e2>", "and", "Gadd45", "in", "negative", "control", "of", "cell", "growth"], "h": {"id": "C1332701", "name": "C1332701#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3814151", "name": "C3814151#ent", "pos": [15, 16]}}
{"token": ["Nail", "avulsion", "by", "long-term", "occlusive", "application", "of", "C0126169#ent", "<e1>", "cleared", "the", "C0040261#ent", "<e2>", ",", "whereas", "the", "sole", "and", "palm", "infection", "resistant", "to", "C0126169#ent", "<e1>", "and", "glutaraldehyde", "treatment", "."], "h": {"id": "C0040261", "name": "C0040261#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0126169", "name": "C0126169#ent", "pos": [7, 8]}}
{"token": ["C0031117#ent", "<e1>", "induced", "in", "rats", "with", "a", "C1289971#ent", "<e2>", "CGS", "21,595", "was", "characterized", "using", "special", "functional", "tests", "pathological", "procedures"], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1289971", "name": "C1289971#ent", "pos": [7, 8]}}
{"token": ["Nitroblue", "tetrazolium", "NBT", ")", "in", "the", "presence", "of", "phenazine", "methosulfate", "C0033046#ent", "<e1>", ")", "reacts", "with", "the", "NADPH", "produced", "by", "C0022917#ent", "<e2>", "to", "produce", "an", "insoluble", "blue-purple", "formazan", "."], "h": {"id": "C0033046", "name": "C0033046#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022917", "name": "C0022917#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "a", "7.2-kDa", "protein", ",", "encoded", "by", "the", "C1412821#ent", "<e1>", ",", "was", "co-isolated", "with", "the", "C0056934#ent", "<e2>", "the", "cyanobacterium", "Synechocystis", "sp.", "PCC", "6803", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0056934", "name": "C0056934#ent", "pos": [16, 17]}}
{"token": ["This", "region", "is", "C1419895#ent", "<e1>", "to", "human", "C0795833#ent", "<e2>", "which", "frequently", "exhibits", "loss", "of", "heterozygosity", "neoplastic", "diseases"], "h": {"id": "C1419895", "name": "C1419895#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0795833", "name": "C0795833#ent", "pos": [7, 8]}}
{"token": ["The", "expression", "of", "proteins", "involved", "in", "erythropoiesis", "regulation", "is", "controlled", "by", "erythropoietin", "(", "C1414438#ent", "<e1>", ")", ",", "which", "decreases", "erythroblast", "susceptibility", "C1539478#ent", "<e2>", "and", "TRAIL", "stimulation", "and", "prevents", "apoptosis", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [21, 22]}}
{"token": ["C0008149#ent", "<e1>", "the", "most", "common", "sexually", "transmitted", "C0004623#ent", "<e2>", "the", "United", "States", "with", "an", "estimated", "3", "million", "new", "cases", "annually", "."], "h": {"id": "C0008149", "name": "C0008149#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}}
{"token": ["Main", "areas", "of", "proliferation", "are", "the", "C0030593#ent", "<e1>", "the", "ciliary", "body", "the", "optic", "disc", "the", "base", "of", "the", "C1256254#ent", "<e2>", "."], "h": {"id": "C0030593", "name": "C0030593#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1256254", "name": "C1256254#ent", "pos": [18, 19]}}
{"token": ["It", "has", "been", "stated", "that", "C0235025#ent", "<e1>", "be", "a", "feature", "of", "so-called", "C0022541#ent", "<e2>", "but", "to", "date", "only", "one", "case", "of", "hypertrophic", "neuropathy", "been", "reported", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0022541", "name": "C0022541#ent", "pos": [12, 13]}}
{"token": ["One", "case", "concerned", "a", "male", "patient", "of", "unknown", "age", "who", "experienced", "weight", "loss", "C1950154#ent", "<e1>", ",", "impatience", "and", "irritability", "soon", "after", "the", "start", "of", "C0005301#ent", "<e2>"], "h": {"id": "C1950154", "name": "C1950154#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0005301", "name": "C0005301#ent", "pos": [24, 25]}}
{"token": ["In", "type", "2", "diabetic", "patients", "with", "C0011881#ent", "<e1>", "6", "months", "of", "treatment", "with", "low", "dose", "C0216784#ent", "<e2>", ",", "an", "angiotensin-II", "receptor", "antagonist", "thus", "reduced", "UAE", "with", "no", "reduction", "in", "systemic", "blood", "pressure"], "h": {"id": "C0011881", "name": "C0011881#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0216784", "name": "C0216784#ent", "pos": [15, 16]}}
{"token": ["Under", "normal", "conditions", ",", "HEMA", "hydrogels", "tend", "to", "swell", "when", "placed", "in", "C0020677#ent", "<e1>", "to", "shrink", "during", "C0001942#ent", "<e2>"], "h": {"id": "C0020677", "name": "C0020677#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [17, 18]}}
{"token": ["The", "apparent", "C0014442#ent", "<e1>", "activation", "energy", "of", "C1415537#ent", "<e2>", "using", "the", "chromogenic", "substrate", "3,3'-dichlorophenolsulfonphthaleinyl", "N-acetyl-beta-D-glucosaminide", "is", "related", "directly", "to", "the", "relative", "proportions", "of", "Hex", "A", "Hex", "B", "isoenzymes", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415537", "name": "C1415537#ent", "pos": [7, 8]}}
{"token": ["They", "include", "the", "products", "of", "at", "least", "three", "genes", "which", "code", "for", "the", "alpha", "and", "beta", "polypeptides", "well", "as", "for", "an", "C0014442#ent", "<e1>", "that", "we", "have", "called", "C1415537#ent", "<e2>", "D."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1415537", "name": "C1415537#ent", "pos": [27, 28]}}
{"token": ["The", "eukaryotic", "transcript", "elongation", "factor", "C1420622#ent", "<e1>", "is", "encoded", "by", "a", "C0600449#ent", "<e2>", "PPR2", ",", "in", "Saccharomyces", "cerevisiae"], "h": {"id": "C1420622", "name": "C1420622#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0600449", "name": "C0600449#ent", "pos": [11, 12]}}
{"token": ["C0151317#ent", "<e1>", "hepatitis", "C", "virus", "HCV", ")", "is", "the", "leading", "cause", "of", "severe", "C0019159#ent", "<e2>", "that", "often", "develops", "into", "liver", "cirrhosis", "hepatocellular", "carcinoma"], "h": {"id": "C0151317", "name": "C0151317#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [13, 14]}}
{"token": ["The", "major", "Ap", "endo", "human", "cells", "Ape1", ",", "an", "abundant", "C0536221#ent", "<e1>", "known", "as", "Ref-1", ",", "C1333571#ent", "<e2>", ",", "and", "Apex", "."], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333571", "name": "C1333571#ent", "pos": [16, 17]}}
{"token": ["The", "use", "of", "a", "C3889123#ent", "<e1>", "stimulator", ",", "veratryl", "alcohol", "did", "not", "increase", "C1418251#ent", "<e2>", "degradation", "but", "significantly", "enhanced", "C3889123#ent", "<e1>", "activity", "."], "h": {"id": "C3889123", "name": "C3889123#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418251", "name": "C1418251#ent", "pos": [13, 14]}}
{"token": ["Here", "we", "demonstrated", "in", "the", "chick", "using", "replication-competent", "retroviruses", "C0669365#ent", "<e1>", "activation", "of", "Calcium/Calmodulin-dependent", "kinase", "II", "CaMKII", ")", "in", "the", "developing", "C3538717#ent", "<e2>", "resulted", "in", "elongation", "of", "skeletal", "elements", "associated", "with", "premature", "differentiation", "chondrocytes", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538717", "name": "C3538717#ent", "pos": [21, 22]}}
{"token": ["SCEs", "were", "significantly", "increased", "in", "cells", "treated", "with", "EDTA", ",", "while", "the", "C1332757#ent", "<e1>", "and", "MI", "were", "significantly", "decreased", "in", "cultures", "treated", "with", "C0002873#ent", "<e2>", "or", "EDTA", "when", "compared", "to", "cultures", "treated", "with", "heparin", "."], "h": {"id": "C1332757", "name": "C1332757#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0002873", "name": "C0002873#ent", "pos": [23, 24]}}
{"token": ["C0030759#ent", "<e1>", "V+S+P+", ")", "show", "good", "stabilisation", "of", "the", "C0235267#ent", "<e2>", "in", "space", ",", "the", "only", "movements", "with", "respect", "to", "external", "coordinates", "being", "saccadic", "resetting", "movements", "fast", "phases", "nystagmus", ")", "."], "h": {"id": "C0030759", "name": "C0030759#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [9, 10]}}
{"token": ["The", "orf", "adjacent", "to", "C1823589#ent", "<e1>", "predicts", "a", "385-amino-acid", "protein", "that", "presents", "significant", "similarity", "with", "C0527356#ent", "<e2>", "the", "integrase", "family"], "h": {"id": "C1823589", "name": "C1823589#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0527356", "name": "C0527356#ent", "pos": [15, 16]}}
{"token": ["Rho", "and", "C0812228#ent", "<e1>", "small", "GTPases", "associate", "with", "type-I", "phosphatidylinositol", "4-phosphate", "5-kinase", "regulate", "the", "production", "of", "C0136804#ent", "<e2>"], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0136804", "name": "C0136804#ent", "pos": [16, 17]}}
{"token": ["5-Lipoxygenase", "produces", "5-hydroperoxy-arachidonic", "acid", ",", "which", "is", "C0025517#ent", "<e1>", "to", "leukotrienes", "B4", "C4", "and", "C1412526#ent", "<e2>", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412526", "name": "C1412526#ent", "pos": [14, 15]}}
{"token": ["A", "higher", "frequency", "of", "C1822794#ent", "<e1>", "uptake", "in", "the", "FA", "was", "seen", "in", "patients", "with", "C0010068#ent", "<e2>", "compared", "with", "those", "without", "C0010068#ent", "<e2>", "."], "h": {"id": "C1822794", "name": "C1822794#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [15, 16]}}
{"token": ["Notable", "exceptions", "included", "RNAi", "of", "C1419034#ent", "<e1>", ",", "a", "polyubiquitin", "binding", "subunit", "and", "dUCH37", ",", "a", "C0294105#ent", "<e2>"], "h": {"id": "C1419034", "name": "C1419034#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0294105", "name": "C0294105#ent", "pos": [16, 17]}}
{"token": ["Among", "the", "serine", "proteinases", ",", "human", "neutrophil", "elastase", "trypsin", "and", "C1413806#ent", "<e1>", "destroyed", "the", "inhibitory", "activity", "of", "C1705819#ent", "<e2>", "against", "MMP-3", "by", "degrading", "the", "inhibitor", "molecule", "into", "small", "fragments"], "h": {"id": "C1413806", "name": "C1413806#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705819", "name": "C1705819#ent", "pos": [17, 18]}}
{"token": ["Corticosteroid", "inhalants", "beclomethasone", "dipropionate", "BDP", ")", "and", "budesonide", ",", "were", "compared", "with", "each", "other", "and", "with", "C0358513#ent", "<e1>", "patients", "with", "steroid", "dependent", "C0004096#ent", "<e2>"], "h": {"id": "C0358513", "name": "C0358513#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [22, 23]}}
{"token": ["C0282616#ent", "<e1>", "HIVAN", ")", "and", "C1535939#ent", "<e2>", "PCP", ")", "typically", "occur", "during", "advanced", "HIV", "infection"], "h": {"id": "C0282616", "name": "C0282616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [5, 6]}}
{"token": ["Mg2+", "Mn2", "+", "inhibited", "hydrolysis", "of", "FPP", "and", "C0210158#ent", "<e1>", ",", "and", "C0210158#ent", "<e1>", "was", "more", "sensitive", "to", "C1417500#ent", "<e1>", "+", "inhibition", "than", "FPP", "."], "h": {"id": "C0210158", "name": "C0210158#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [18, 19]}}
{"token": ["In", "the", "treatment", "of", "the", "C0007286#ent", "<e1>", "simple", "division", "of", "the", "transverse", "carpal", "ligament", "causes", "a", "certain", "C0427055#ent", "<e2>", "of", "the", "grip", "strength", "which", "takes", "a", "very", "long", "to", "recover", "."], "h": {"id": "C0007286", "name": "C0007286#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [17, 18]}}
{"token": ["To", "explore", "the", "involvement", "of", "EEN", "in", "leukemogenesis", "caused", "by", "C1866327#ent", "<e1>", ",", "we", "studied", "the", "transformation", "potential", "of", "the", "C3274774#ent", "<e2>"], "h": {"id": "C1866327", "name": "C1866327#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3274774", "name": "C3274774#ent", "pos": [20, 21]}}
{"token": ["Neurotoxic", "amyloid", "beta", "peptide", "C1705543#ent", "<e1>", ")", "accumulates", "in", "the", "brains", "of", "individuals", "with", "C0002395#ent", "<e2>", "AD", ")", "."], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [14, 15]}}
{"token": ["C0836924#ent", "<e1>", "has", "not", "yet", "been", "described", "in", "C0034068#ent", "<e2>"], "h": {"id": "C0836924", "name": "C0836924#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034068", "name": "C0034068#ent", "pos": [8, 9]}}
{"token": ["Importantly", ",", "C1418845#ent", "<e1>", "not", "only", "dephosphorylates", "the", "C1623430#ent", "<e2>", "at", "Ser-243", "but", "also", "interacts", "with", "C1623430#ent", "<e2>", "in", "PMA-treated", "cells", "."], "h": {"id": "C1418845", "name": "C1418845#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [8, 9]}}
{"token": ["To", "define", "their", "functions", "in", "an", "insulin", "secreting", "system", "effects", "of", "ATRA", ",", "9cRA", "and", "the", "C1335238#ent", "<e1>", "rosiglitazone", "on", "cell", "proliferation", "insulin", "release", "and", "glucose", "transporter", "C1335837#ent", "<e2>", ")", "2", "of", "INS-1", "cells", "were", "tested", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1335837", "name": "C1335837#ent", "pos": [27, 28]}}
{"token": ["Plasma", "levels", "and", "diuretic", "response", "determined", "in", "seven", "healthy", "subjects", "six", "patients", "with", "severe", "C0027726#ent", "<e1>", "NS", ")", "after", "40", "mg", "C0016860#ent", "<e2>", "(", "Fu", ")", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0016860", "name": "C0016860#ent", "pos": [21, 22]}}
{"token": ["Kallmann", "syndrome", "to", "C2697833#ent", "<e1>", "and", "adrenal", "hypoplasia", "caused", "by", "C2698419#ent", "<e2>", "gene", "mutations", "both", "X-linked", "recessive", "disorders"], "h": {"id": "C2697833", "name": "C2697833#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2698419", "name": "C2698419#ent", "pos": [10, 11]}}
{"token": ["These", "findings", "show", "that", "acute", "administration", "C0031507#ent", "<e1>", "augmented", "the", "neuromuscular", "blocking", "of", "C0069632#ent", "<e2>", ",", "whereas", "chronic", "C0031507#ent", "<e1>", "treatment", "causes", "resistance", "to", "the", "neuromuscular", "blocking", "of", "C0069632#ent", "<e2>", "in", "target", "organs", "."], "h": {"id": "C0069632", "name": "C0069632#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031507", "name": "C0031507#ent", "pos": [6, 7]}}
{"token": ["Although", "generally", "well", "tolerated", ",", "gastrointestinal", "adverse", "effects", "relatively", "common", "with", "C0663241#ent", "<e1>", "and", "it", "has", "been", "associated", "with", "C1839163#ent", "<e2>", "and", "myelosuppression", "."], "h": {"id": "C0663241", "name": "C0663241#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [19, 20]}}
{"token": ["C0021246#ent", "<e1>", "significantly", "inhibited", "the", "IOP", "reduction", "after", "one", "dose", "of", "C0054222#ent", "<e2>", ",", "whereas", "flurbiprofen", "did", "not", "(", "repeated", "measures", "ANOVA", ")", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054222", "name": "C0054222#ent", "pos": [11, 12]}}
{"token": ["It", "has", "been", "shown", "previously", "that", "mutations", "in", "the", "C1418887#ent", "<e1>", "PRF1", ")", "and", "in", "UNC13D", "are", "associated", "with", "FHL2", "and", "C1414613#ent", "<e2>", ",", "respectively", ",", "indicating", "genetic", "heterogeneity"], "h": {"id": "C1418887", "name": "C1418887#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414613", "name": "C1414613#ent", "pos": [21, 22]}}
{"token": ["The", "clinical", "and", "radiologic", "phenotype", "of", "atelosteogenesis", ",", "type", "III", "with", "that", "of", "another", "skeletal", "dysplasia", "autosomal", "dominant", "C0175778#ent", "<e1>", "these", "most", "likely", "represent", "C0002085#ent", "<e2>", "conditions", "."], "h": {"id": "C0175778", "name": "C0175778#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [24, 25]}}
{"token": ["Altogether", "the", "present", "results", "suggest", "that", "focal", "cerebral", "ischemia", "induce", "in", "different", "cell", "types", "C0907533#ent", "<e1>", "which", "is", "equivalent", "to", "C1417616#ent", "<e2>", "in", "fixed", "tissue"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417616", "name": "C1417616#ent", "pos": [20, 21]}}
{"token": ["Mouse", "glomerular", "C0268747#ent", "<e1>", "and", "proximal", "tubular", "epithelial", "cells", "constitutively", "express", "C0057252#ent", "<e2>", ",", "and", "high", "glucose", "450", "mg/dl", ")", "increases", "C0057252#ent", "<e2>", "mRNA", "fourfold", "compared", "with", "100", "mg/dl", "glucose", "."], "h": {"id": "C0268747", "name": "C0268747#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0057252", "name": "C0057252#ent", "pos": [11, 12]}}
{"token": ["This", "D1R-mediated", "JNK", "activation", "required", "the", "participation", "of", "Gbetagamma", ",", "Src-like", "kinases", "and", "C0751984#ent", "<e1>", "whereas", "disruptions", "of", "cAMP-", ",", "C1418575#ent", "<e2>", ",", "and", "epidermal", "growth", "factor", "receptor-mediated", "signaling", "no", "effect"], "h": {"id": "C0751984", "name": "C0751984#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418575", "name": "C1418575#ent", "pos": [20, 21]}}
{"token": ["The", "CD94/NKG2", "and", "C1425775#ent", "<e1>", "lectin-like", "molecules", ",", "respectively", ",", "interact", "with", "C1415585#ent", "<e2>", "and", "MICA", ";", "CD94/NKG2A", "functions", "as", "an", "inhibitory", "receptor", "while", "CD94/NKG2C", "and", "C1425775#ent", "<e1>", "trigger", "NK", "cell", "."], "h": {"id": "C1425775", "name": "C1425775#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415585", "name": "C1415585#ent", "pos": [12, 13]}}
{"token": ["C0047123#ent", "<e1>", "and", "TFMPP", "were", "partial", "C2987634#ent", "<e2>", "in", "the", "rat", "stomach", "fundus", "LY165163", "showed", "no", "agonist", "activity", "this", "smooth", "muscle", "concentrations", "up", "to", "10(-4)M.", "All", "three", "phenylpiperazines", "antagonized", "serotonin-induced", "contractions", "in", "the", "rat", "stomach", "fundus"], "h": {"id": "C0047123", "name": "C0047123#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}}
{"token": ["Recombinant", "human", "glucocerebrosidase", "C0291140#ent", "<e1>", ",", "Cerezyme", ")", "is", "used", "in", "enzyme", "replacement", "therapy", "C0017205#ent", "<e2>"], "h": {"id": "C0291140", "name": "C0291140#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0017205", "name": "C0017205#ent", "pos": [14, 15]}}
{"token": ["The", "present", "study", "provides", "the", "first", "demonstration", "that", "C0064858#ent", "<e1>", "induces", "lipofuscin-like", "substances", "in", "normal", "young", "rat", "C0669372#ent", "<e2>", "."], "h": {"id": "C0064858", "name": "C0064858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [17, 18]}}
{"token": ["The", "National", "Animal", "Disease", "Laboratory", "NADL", ")", "vaccine", "strain", "bovine", "viral", "diarrhea", "virus", "BVDV", ")", "C0017337#ent", "<e1>", "for", "gp48", "and", "C1708432#ent", "<e2>", "were", "expressed", "in", "Escherichia", "coli"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1708432", "name": "C1708432#ent", "pos": [20, 21]}}
{"token": ["The", "results", "in", "sporotrichosis", ",", "non-meningeal", "blastomycosis", "and", "C0030409#ent", "<e1>", "suggest", "that", "for", "these", "C0012634#ent", "<e2>", "itraconazole", "may", "be", "the", "drug", "of", "choice", "."], "h": {"id": "C0030409", "name": "C0030409#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["The", "pharmacological", "targeting", "of", "C0694888#ent", "<e1>", "may", "constitute", "a", "new", "strategy", "for", "the", "treatment", "of", "C1306759#ent", "<e2>"], "h": {"id": "C0694888", "name": "C0694888#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [15, 16]}}
{"token": ["These", "points", "of", "intervention", "form", "the", "basis", "for", "our", "discussion", "of", "such", "varied", "potential", "therapies", "for", "C0017665#ent", "<e1>", ":", "vaccines", ",", "inhibitors", "of", "C0032143#ent", "<e2>", "humanized", "monoclonal", "antibodies", "mycophenolate", "mofetil", "pentoxifylline", ",", "and", "others", "."], "h": {"id": "C0017665", "name": "C0017665#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0032143", "name": "C0032143#ent", "pos": [23, 24]}}
{"token": ["Representative", "examples", "from", "different", "studies", "include", "C0085196#ent", "<e1>", ",", "muscimol", ",", "and", "C0037567#ent", "<e2>"], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0037567", "name": "C0037567#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "the", "polyamine", "synthesis", "inhibitors", "difluoromethylornithine", "(", "DFMO", ")", ",", "and", "methylglyoxal", "bis-(guanylhydrazone)", "C0026251#ent", "<e1>", ")", ",", "inhibited", "cell", "proliferation", "delayed", "(3)H-thymidine", "incorporation", "in", "C3811170#ent", "<e2>", "cultured", "on", "all", "of", "the", "substrates", "."], "h": {"id": "C0026251", "name": "C0026251#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3811170", "name": "C3811170#ent", "pos": [25, 26]}}
{"token": ["Isoleucine-restricted", "growth", "caused", "a", "maximal", "derepression", "of", "isoleucyl-tRNA", "synthetase", "formation", "in", "5", "min", "and", "derepression", "of", "C0042301#ent", "<e1>", "formation", "in", "15", "min", "with", "no", "effect", "C0023414#ent", "<e2>", "formation", "."], "h": {"id": "C0042301", "name": "C0042301#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0023414", "name": "C0023414#ent", "pos": [25, 26]}}
{"token": ["A", "condition", "called", "C1959620#ent", "<e1>", "been", "described", "that", "is", "due", "to", "a", "lack", "of", "C1366555#ent", "<e2>", "DPD", ")", "activity", "."], "h": {"id": "C1959620", "name": "C1959620#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1366555", "name": "C1366555#ent", "pos": [14, 15]}}
{"token": ["C0069765#ent", "<e1>", ",", "a", "new", "imidazole", "derivative", "has", "a", "broad", "C0003308#ent", "<e2>", "in", "vitro", "in", "vivo"], "h": {"id": "C0069765", "name": "C0069765#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [10, 11]}}
{"token": ["C1622105#ent", "<e1>", "may", "act", "by", "enhancing", "the", "effect", "of", "NO", "on", "C0671566#ent", "<e2>", "increasing", "the", "formation", "of", "cyclic", "3',5'-guanosine", "monophosphate", "cGMP", ")", ",", "and", "thereby", "resulting", "in", "vasodilatation", "."], "h": {"id": "C1622105", "name": "C1622105#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0671566", "name": "C0671566#ent", "pos": [11, 12]}}
{"token": ["Biophysical", "studies", "the", "interactions", "of", "various", "benzodiazepine", "derivatives", "annexins", "were", "performed", "to", "analyze", "the", "binding", "of", "C4048284#ent", "<e1>", "to", "annexins", "and", "their", "effects", "on", "the", "annexin-induced", "calcium", "influx", "C1450468#ent", "<e2>"], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1450468", "name": "C1450468#ent", "pos": [28, 29]}}
{"token": ["Serum", "ionized", "calcium", "increased", "by", "6", "%", "to", "8", "%", "after", "each", "C3710848#ent", "<e1>", "bolus", "but", "remained", "stable", "in", "the", "C0014479#ent", "<e2>", "and", "placebo", "groups", "."], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014479", "name": "C0014479#ent", "pos": [20, 21]}}
{"token": ["C1332806#ent", "<e1>", "hydrolyzing", "activity", "was", "low", "and", "not", "significantly", "affected", "by", "C0055730#ent", "<e2>", "treatment", "."], "h": {"id": "C1332806", "name": "C1332806#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0055730", "name": "C0055730#ent", "pos": [11, 12]}}
{"token": ["In", "mammals", ",", "three", "ras", "genes", "H-ras", ",", "C1705519#ent", "<e1>", "and", "K-ras", ",", "encode", "C1512488#ent", "<e2>", "but", "distinct", "21-kDa", "Ras", "proteins"], "h": {"id": "C1705519", "name": "C1705519#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [14, 15]}}
{"token": ["In", "mammalian", "cells", "three", "ras", "genes", "four", "Ras", "isoforms", "H-Ras", ",", "K-Ras4A", ",", "K-Ras4B", "and", "C1705519#ent", "<e1>", ")", "that", "are", "highly", "C1512488#ent", "<e2>", "but", "functionally", "distinct", "."], "h": {"id": "C1705519", "name": "C1705519#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [21, 22]}}
{"token": ["Esomeprazole", "20", "mg", "od", "has", "also", "been", "shown", "to", "be", "more", "effective", "in", "maintaining", "healing", "of", "erosive", "C0017168#ent", "<e1>", "compared", "with", "C0050940#ent", "<e2>", "15", "mg", "od", "or", "pantoprazole", "20", "mg", "od", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0050940", "name": "C0050940#ent", "pos": [21, 22]}}
{"token": ["The", "dosage", "range", "used", "for", "the", "management", "of", "C0017168#ent", "<e1>", "and", "related", "disorders", "with", "C0050940#ent", "<e2>", "was", "0.73", "-", "1.66", "mg/kg/day", "(", "maximum", "30", "mg/day", ")", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0050940", "name": "C0050940#ent", "pos": [14, 15]}}
{"token": ["Tumor", "cell-derived", "supernatant", "suppressed", "C0144576#ent", "<e1>", "capacity", "to", "induce", "IL-12", ",", "C0812246#ent", "<e2>", ",", "and", "NO", "production", "by", "RAW264.7", "M\u00f8", "."], "h": {"id": "C0144576", "name": "C0144576#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [11, 12]}}
{"token": ["Additionally", ",", "higher", "enzimatic", "activity", "of", "proteases", ",", "C0031672#ent", "<e1>", ",", "phenoloxidase", "and", "C0005223#ent", "<e2>", "was", "observed", "in", "var", "."], "h": {"id": "C0031672", "name": "C0031672#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005223", "name": "C0005223#ent", "pos": [13, 14]}}
{"token": ["We", "have", "studied", "the", "possible", "involvement", "of", "the", "activation", "of", "calcium-dependent", "phospholipid-activated", "protein", "kinase", "PK-C", ")", "in", "the", "stimulatory", "action", "C1415169#ent", "<e1>", "on", "Leydig", "cells", "using", "4", "C1321914#ent", "<e2>", "(", "PMA", ")", "and", "phospholipase", "C", "PL-C", ")", "."], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [27, 28]}}
{"token": ["The", "caries", "susceptibility", "and", "the", "apical", "periodontitis", "the", "intact", "anterior", "tooth", "the", "female", "patient", "indicate", "the", "possibility", "of", "C0221023#ent", "<e1>", "a", "role", "in", "caries", "and", "C0011407#ent", "<e2>", "pathology", "."], "h": {"id": "C0221023", "name": "C0221023#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0011407", "name": "C0011407#ent", "pos": [25, 26]}}
{"token": ["Twenty-two", "patients", "with", "chronic", "productive", "bronchitis", "C0006267#ent", "<e1>", "were", "treated", "by", "instillations", "of", "normal", "saline", "and", "C0001047#ent", "<e2>", "into", "the", "trachea", "through", "a", "percutaneous", "catheter", "a", "period", "of", "conventional", "routine", "therapy", "."], "h": {"id": "C0006267", "name": "C0006267#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0001047", "name": "C0001047#ent", "pos": [16, 17]}}
{"token": ["Concomitant", "chronic", "C0771848#ent", "<e1>", "treatment", "with", "inhibitors", "of", "C2936824#ent", "<e2>", "mitogen-activated", "protein", "kinase", "pathways", "inhibited", "nicotinic", "receptor", "up-regulation", "and", "enhancement", "of", "the", "response", "to", "nicotine", ",", "and", "enhanced", "the", "sensitivity", "to", "C0771848#ent", "<e1>", "."], "h": {"id": "C0771848", "name": "C0771848#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggested", "that", "C0115343#ent", "<e1>", "has", "both", "bradycardiac", "and", "C0596385#ent", "<e2>", "and", "that", "activation", "of", "ATP-sensitive", "K+", "channel", "to", "the", "vasodilating", "action", "C0115343#ent", "<e1>", "but", "not", "to", "the", "bradycardiac", "action"], "h": {"id": "C0596385", "name": "C0596385#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0115343", "name": "C0115343#ent", "pos": [4, 5]}}
{"token": ["Before", "1990", ",", "and", "for", "most", "of", "the", "20th", "century", ",", "C0016053#ent", "<e1>", "was", "considered", "to", "be", "predominantly", "a", "C0026848#ent", "<e2>", "now", "the", "critical", "abnormality", "described", "as", "\"", "central", "sensitization"], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [11, 12]}, "relation": "related_to", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [19, 20]}}
{"token": ["Several", "initiation", "factors", "eIF-2", ",", "eIF-3", ",", "eIF-4A", ",", "C0058985#ent", "<e1>", ",", "eIF-4C", ",", "eIF-4E", "and", "eIF-5", ")", "and", "C0059036#ent", "<e2>", "found", "to", "have", "no", "such", "discriminatory", "effect", "."], "h": {"id": "C0058985", "name": "C0058985#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [19, 20]}}
{"token": ["This", "pA2", "value", "was", "lower", "than", "that", "when", "C0001927#ent", "<e1>", "was", "used", "as", "an", "C0243192#ent", "<e2>", "(", "p", "<", "0.05", ")", "."], "h": {"id": "C0001927", "name": "C0001927#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [14, 15]}}
{"token": ["C0669372#ent", "<e1>", "was", "localized", "to", "nerve", "cell", "bodies", "nerve", "fibre", "C0042345#ent", "<e2>", "of", "the", "myenteric", "plexus", "wholemounts", "of", "the", "longitudinal", "muscle-myenteric", "plexus", "of", "the", "stomach", "fundus"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [10, 11]}}
{"token": ["Together", "these", "studies", "suggest", "a", "dynamic", "model", "for", "the", "cooperation", "of", "pRb", "and", "C1423614#ent", "<e1>", "in", "repression", "of", "C1333216#ent", "<e2>", "expression", "during", "withdrawal", "from", "the", "cell", "cycle"], "h": {"id": "C1423614", "name": "C1423614#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333216", "name": "C1333216#ent", "pos": [18, 19]}}
{"token": ["Both", "CGS", "19755", "C0045376#ent", "<e1>", "significantly", "attenuated", "the", "sensitized", "response", "to", "C0035334#ent", "<e2>", "in", "intact", "and", "spinalized", "animals", "."], "h": {"id": "C0045376", "name": "C0045376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [11, 12]}}
{"token": ["On", "the", "other", "hand", ",", "the", "other", "3", "cases", "with", "C0014013#ent", "<e1>", "who", "underwent", "open", "drainage", "thoracotomy", "recovered", "without", "complication", "showed", "recovery", "of", "C1416706#ent", "<e2>", "and", "MEP", "one", "month", "after", "surgery", "."], "h": {"id": "C0014013", "name": "C0014013#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416706", "name": "C1416706#ent", "pos": [23, 24]}}
{"token": ["Some", "patients", "had", "only", "ocular", "myopathy", "whereas", "others", "had", "C0022541#ent", "<e1>", "a", "multisystem", "disorder", "by", "ophthalmoplegia", ",", "pigmentary", "retinopathy", "heart", "block", "and", "C0007758#ent", "<e2>"], "h": {"id": "C0022541", "name": "C0022541#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0007758", "name": "C0007758#ent", "pos": [22, 23]}}
{"token": ["The", "usefulness", "of", "selective", "inhibitors", "type", "4", "phosphodiesterase", "C2936609#ent", "<e1>", ")", "in", "the", "treatment", "of", "inflammation", "and", "C0024115#ent", "<e2>", "limited", "by", "their", "side", "effects", "nausea", "and", "vomiting", "."], "h": {"id": "C2936609", "name": "C2936609#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [17, 18]}}
{"token": ["C1861185#ent", "<e1>", "common", "in", "isolated", "falciparum", "and", "mixed", "falciparum/vivax", "C0024530#ent", "<e2>", ",", "but", "is", "very", "rare", "in", "isolated", "P.vivax", "infection", "."], "h": {"id": "C1861185", "name": "C1861185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [9, 10]}}
{"token": ["The", "C0298973#ent", "<e1>", "used", "to", "determine", "Peripheral", "blood", "mononuclear", "cell", "proliferation", "activity", "C0003392#ent", "<e2>", "in", "vitro"], "h": {"id": "C0298973", "name": "C0298973#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [12, 13]}}
{"token": ["This", "prospective", "randomized", "study", "the", "efficacy", "and", "toxicity", "of", "C0543476#ent", "<e1>", "and", "C0011777#ent", "<e2>", "to", "those", "of", "C0543476#ent", "<e1>", "alone", "for", "antiemetic", "control", "in", "patients", "receiving", "high-dose", "chemotherapy", "or", "without", "total", "body", "irradiation", "TBI", ")", "for", "stem", "cell", "transplantation"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0543476", "name": "C0543476#ent", "pos": [9, 10]}}
{"token": ["The", "three", "proteins", "do", "not", "bind", "to", "other", "anionic", "lipids", "including", "C0017083#ent", "<e1>", ",", "phospholipids", ",", "or", "C0052456#ent", "<e2>"], "h": {"id": "C0017083", "name": "C0017083#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0052456", "name": "C0052456#ent", "pos": [17, 18]}}
{"token": ["Each", "C1254351#ent", "<e1>", "was", "given", "for", "a", "two-month", "period", ",", "the", "maximum", "C0000946#ent", "<e2>", "dosage", "reaching", "600", "mg", "tid", "and", "the", "maximum", "propranolol", "dosage", "80", "mg", "tid", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000946", "name": "C0000946#ent", "pos": [12, 13]}}
{"token": ["Here", "we", "show", "that", "14", "-", "3", "-", "3", "C0086376#ent", "<e1>", "interact", "with", "phosphorylated", "serine", "9", "the", "N", "terminus", "of", "C1428807#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1428807", "name": "C1428807#ent", "pos": [20, 21]}}
{"token": ["Of", "those", "with", "nephrotic", "syndrome", "five", "had", "minimal", "change", "disease", "nine", "C0017668#ent", "<e1>", "six", "membraneous", "nephropathy", "three", "C0002726#ent", "<e2>", "."], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002726", "name": "C0002726#ent", "pos": [17, 18]}}
{"token": ["We", "have", "produced", "hybrid", "chitinases", "with", "stronger", "chitin-binding", "capacity", "by", "fusing", "to", "Chit42", "a", "C1415483#ent", "<e1>", "from", "Nicotiana", "tabacum", "ChiA", "chitinase", "the", "cellulose-binding", "domain", "from", "C0752535#ent", "<e2>", "Trichoderma", "reesei"], "h": {"id": "C1415483", "name": "C1415483#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0752535", "name": "C0752535#ent", "pos": [25, 26]}}
{"token": ["Comparative", "analysis", "the", "deduced", "amino", "acid", "sequence", "high", "similarity", "to", "C1334043#ent", "<e1>", "for", "other", "eukaryotic", "C2699545#ent", "<e2>", "enzymes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2699545", "name": "C2699545#ent", "pos": [15, 16]}}
{"token": ["The", "pharmaceutical", "compounds/metabolites", "clofibric", "acid", ",", "clotrimazole", ",", "C0033493#ent", "<e1>", ",", "diclofenac", ",", "ibuprofen", ",", "C0025152#ent", "<e2>", "propranolol", ",", "tamoxifen", "and", "trimethoprim", "were", "detected", "at", "measurable", "concentrations", "in", "the", "samples", "collected", "."], "h": {"id": "C0033493", "name": "C0033493#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025152", "name": "C0025152#ent", "pos": [15, 16]}}
{"token": ["The", "activation", "of", "the", "NADPH", "oxidase", "largely", "involved", "in", "inflammation", "associated", "diseases", "such", "as", "asthma", ",", "C0242966#ent", "<e1>", "aging", "associated", "diseases", "such", "as", "C0004153#ent", "<e2>", "and", "neurodeneratives", "diseases"], "h": {"id": "C0242966", "name": "C0242966#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [23, 24]}}
{"token": ["The", "hypothetical", "product", "of", "the", "C1413694#ent", "<e1>", "similar", "to", "the", "transcriptional", "regulatory", "proteins", "encoded", "by", "C1424135#ent", "<e2>", ",", "and", "YAP2", "genes", "S.", "cerevisiae"], "h": {"id": "C1413694", "name": "C1413694#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424135", "name": "C1424135#ent", "pos": [15, 16]}}
{"token": ["Mice", "expressing", "wild-type", "and", "Y175A", "rbCRP", "were", "protected", "against", "challenge", "by", "C0235480#ent", "<e1>", "whereas", "mice", "expressing", "F66Y/E81", "K", "C1332002#ent", "<e2>", "were", "not", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332002", "name": "C1332002#ent", "pos": [18, 19]}}
{"token": ["Frequencies", "of", "DAP-kinase", "and", "C1419772#ent", "<e1>", "methylation", "differed", "significantly", "in", "C1709246#ent", "<e2>", "P", "<", "0.01", ")", ",", "although", "those", "in", "gastric", "cancers", "almost", "the", "same", "."], "h": {"id": "C1419772", "name": "C1419772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709246", "name": "C1709246#ent", "pos": [10, 11]}}
{"token": ["In", "LH", ",", "severe", "C0018681#ent", "<e1>", "was", "more", "common", "than", "in", "C1832586#ent", "<e2>", ",", "while", "hypertension", "and", "motor", "deficit", "significantly", "less", "common", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1832586", "name": "C1832586#ent", "pos": [11, 12]}}
{"token": ["Radioiodination", "with", "lactoperoxidase", "showed", "the", "presence", "of", "the", "C1305923#ent", "<e1>", "of", "glycoprotein", "C2700453#ent", "<e2>", "in", "S-s-cells", ",", "although", "it", "was", "more", "weakly", "labelled", "than", "the", "protein", "in", "the", "normal", "erythrocyte", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2700453", "name": "C2700453#ent", "pos": [12, 13]}}
{"token": ["In", "this", "report", ",", "we", "prospectively", "evaluated", "for", "one", "year", ",", "anatomical", ",", "functional", "and", "C0034951#ent", "<e1>", "results", "of", "a", "group", "of", "18", "eyes", "treated", "with", "C0076549#ent", "<e2>", "(", "14", "patients", ")", "."], "h": {"id": "C0034951", "name": "C0034951#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0076549", "name": "C0076549#ent", "pos": [26, 27]}}
{"token": ["The", "acute-phase", "reaction", "C1705517#ent", "<e1>", ")", "induces", "the", "production", "by", "the", "C0023899#ent", "<e2>", "of", "short-lived", "glycoproteins", "."], "h": {"id": "C1705517", "name": "C1705517#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}}
{"token": ["In", "the", "guinea-pig", "isolated", "bladder", ",", "FMLP", "(", "10", "nM-10", "microM", ")", "produced", "a", "concentration-dependent", "contraction", "which", "was", "unchanged", "by", "previous", "in", "vitro", "C0006931#ent", "<e1>", ",", "TTX", "or", "C0631180#ent", "<e2>", "pretreatment", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0631180", "name": "C0631180#ent", "pos": [28, 29]}}
{"token": ["BAY11", "-", "7085", "and", "C0054434#ent", "<e1>", ",", "inhibitors", "of", "NF-kappaB", "activity", "did", "not", "alter", "the", "C0597861#ent", "<e2>", "A-stimulated", "TNF-alpha", "mRNA", "expression", "."], "h": {"id": "C0054434", "name": "C0054434#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597861", "name": "C0597861#ent", "pos": [15, 16]}}
{"token": ["During", "the", "first", "trimester", "of", "pregnancy", "C0008370#ent", "<e1>", "may", "occur", "in", "C0020450#ent", "<e2>", "gravidorum", ",", "and", "in", "the", "third", "trimester", "gestation", "C0008370#ent", "<e1>", "of", "pregnancy", "should", "be", "suspected", "."], "h": {"id": "C0020450", "name": "C0020450#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008370", "name": "C0008370#ent", "pos": [6, 7]}}
{"token": ["Recently", ",", "an", "autosomal", "recessive", "form", "C0034152#ent", "<e1>", "was", "mapped", "to", "16q24.3", ",", "and", "subsequently", "the", "defective", "C0017337#ent", "<e2>", "associated", "to", "C0034152#ent", "<e1>", "was", "identified", "and", "designated", "SPG7", "."], "h": {"id": "C0034152", "name": "C0034152#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}}
{"token": ["Over", "the", "last", "decade", ",", "eosinophilic", "C0017178#ent", "<e1>", "emerged", "as", "increasingly", "recognised", "C0012634#ent", "<e2>", "affecting", "both", "adults", "and", "children", "."], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [6, 7]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [12, 13]}}
{"token": ["Archaea", "possess", "C1334043#ent", "<e1>", "of", "alpha", ",", "beta", ",", "and", "delta", "subunits", "of", "C1414330#ent", "<e2>", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414330", "name": "C1414330#ent", "pos": [13, 14]}}
{"token": ["However", ",", "C0031117#ent", "<e1>", "recently", "reported", "in", "a", "group", "of", "healthy", "volunteers", "received", "C0074414#ent", "<e2>", "."], "h": {"id": "C0031117", "name": "C0031117#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0074414", "name": "C0074414#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "H.", "pylori", ",", "in", "part", ",", "aspirin-induced", "delay", "ulcer", "healing", "to", "suppression", "of", "acid", "secretion", "the", "enhancement", "in", "prostaglandin", "E(2)", "derived", "from", "C1565860#ent", "<e1>", "and", "the", "overexpression", "of", "C1336620#ent", "<e2>", "vascular", "endothelial", "growth", "factor", "the", "ulcer", "area"], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1336620", "name": "C1336620#ent", "pos": [31, 32]}}
{"token": ["The", "hexokinase", "from", "Y.", "lipolytica", "effectively", "for", "C0019472#ent", "<e1>", "S.", "cerevisiae", "catabolite", "repression", "of", "C0053409#ent", "<e2>", "."], "h": {"id": "C0019472", "name": "C0019472#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0053409", "name": "C0053409#ent", "pos": [14, 15]}}
{"token": ["AMPA", "(", "7", ")", "and", "the", "higher", "homologue", "of", "homo-AMPA", "(", "8)", ",", "(RS)-2-amino-5-(3-hydroxy-5-methylisoxazol-4-yl)pentanoic", "acid", "(", "9", ")", ",", "showed", "relatively", "weak", "C0243192#ent", "<e1>", "effects", "at", "C1706588#ent", "<e2>", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1706588", "name": "C1706588#ent", "pos": [26, 27]}}
{"token": ["Thus", ",", "the", "block", "of", "apoptosis", "imposed", "by", "C3274663#ent", "<e1>", "in", "pro-B", "lymphocytes", "critically", "on", "the", "transactivating", "regions", "C1336596#ent", "<e2>", "."], "h": {"id": "C3274663", "name": "C3274663#ent", "pos": [8, 9]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [18, 19]}}
{"token": ["To", "study", "the", "role", "of", "intercellular", "adhesion", "molecule-1", "ICAM-1", ")", "and", "lymphocyte", "function-associated", "antigen-1", "C1334146#ent", "<e1>", ")", "in", "the", "pathogenesis", "of", "C0019159#ent", "<e2>"], "h": {"id": "C1334146", "name": "C1334146#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [21, 22]}}
{"token": ["We", "have", "concluded", "that", "C0796126#ent", "<e1>", "represent", "a", "fundamental", "genetic", "feature", "the", "C4049728#ent", "<e2>", "."], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4049728", "name": "C4049728#ent", "pos": [12, 13]}}
{"token": ["One", "of", "the", "gene", "fragments", "was", "C1512488#ent", "<e1>", "to", "human", "C1419992#ent", "<e2>", "the", "mouse", "counterpart", "had", "not", "then", "been", "cloned", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419992", "name": "C1419992#ent", "pos": [10, 11]}}
{"token": ["MAPKs", ",", "which", "activate", "MEF2", "by", "phosphorylation", "of", "the", "transcription", "activation", "domain", "maximally", "stimulate", "MEF2", "activity", "only", "when", "repression", "by", "C0019643#ent", "<e1>", "is", "relieved", "by", "C0769224#ent", "<e2>", "signaling", "to", "the", "DNA-binding", "domain"], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0769224", "name": "C0769224#ent", "pos": [25, 26]}}
{"token": ["Rho-kinase", "inhibition", "reduces", "cerebral", "infarct", "in", "C1883559#ent", "<e1>", "but", "not", "C0907532#ent", "<e2>", "eNOS-/-", ")", "mice", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0907532", "name": "C0907532#ent", "pos": [10, 11]}}
{"token": ["Repeated", "administration", "of", "either", "imipramine", ",", "C0024778#ent", "<e1>", ",", "mianserin", ",", "carbamazepine", "or", "C0078849#ent", "<e2>", "were", "without", "effect", "on", "somatostatin", "levels"], "h": {"id": "C0024778", "name": "C0024778#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0078849", "name": "C0078849#ent", "pos": [13, 14]}}
{"token": ["Most", "previous", "studies", "on", "surgery", "for", "C0014118#ent", "<e1>", "included", "cases", "of", "both", "prosthetic", "and", "native", "C1142550#ent", "<e2>", "NVE", ")", ",", "which", "clearly", "differ", "in", "their", "course", "and", "prognosis", "."], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C1142550", "name": "C1142550#ent", "pos": [15, 16]}}
{"token": ["The", "C1538856#ent", "<e1>", "been", "implicated", "in", "plexin-B1", ",", "a", "receptor", "for", "C1419950#ent", "<e2>", "Sema4D", ")", ",", "mediating", "signal", "transduction"], "h": {"id": "C1538856", "name": "C1538856#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1419950", "name": "C1419950#ent", "pos": [11, 12]}}
{"token": ["C8", "denaturation", "by", "C3273614#ent", "<e1>", "and", "urea", "in", "the", "absence", "of", "reducing", "C0991617#ent", "<e2>", "revealed", "two", "noncovalently", "linked", "subunits", ":", "alpha-gamma", ",", "99,000", "daltons", ",", "and", "beta", ",", "75,000", "daltons", "."], "h": {"id": "C3273614", "name": "C3273614#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [12, 13]}}
{"token": ["As", "a", "result", ",", "medications", "that", "contain", "salmeterol", "(", "Serevent", ",", "C0965130#ent", "<e1>", ")", "or", "formoterol", "(", "C0592533#ent", "<e2>", ")", "carry", "a", "\"", "black", "box", "warning", "."], "h": {"id": "C0965130", "name": "C0965130#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0592533", "name": "C0592533#ent", "pos": [17, 18]}}
{"token": ["The", "protein", "lacks", "the", "extensive", "proline", "rich", "domain", "C0079686#ent", "<e1>", "in", "c-cbl", "and", "C1332672#ent", "<e2>", "and", "structurally", "most", "resembles", "the", "C.", "elegans", "Drosophila", "cbl", "proteins"], "h": {"id": "C0079686", "name": "C0079686#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332672", "name": "C1332672#ent", "pos": [13, 14]}}
{"token": ["Some", "of", "the", "collagen-vascular", "diseases", "overlap", "syndromes", "are", "C0085655#ent", "<e1>", ",", "systemic", "lupus", "erythematosus", "scleroderma", ",", "Sj\u00f6gren's", "syndrome", "and", "C0034734#ent", "<e2>", "phenomenon", "."], "h": {"id": "C0085655", "name": "C0085655#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034734", "name": "C0034734#ent", "pos": [19, 20]}}
{"token": ["This", "protective", "effect", "CsA", "was", "strongly", "associated", "with", "C1334912#ent", "<e1>", "inhibition", ",", "increased", "expression", "of", "anti-apoptotic", "factors", "as", "C1332397#ent", "<e2>", ")", "and", "NF-kappaB", ",", "as", "well", "as", "suppression", "of", "caspase-3", "activity"], "h": {"id": "C1334912", "name": "C1334912#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332397", "name": "C1332397#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "the", "native", "structure", "of", "the", "transmembrane", "component", "is", "required", "to", "form", "a", "normal", "C0056562#ent", "<e1>", "ER", "and", "to", "allow", "the", "C0014442#ent", "<e2>", "to", "undergo", "regulated", "degradation", "by", "sterols", "."], "h": {"id": "C0056562", "name": "C0056562#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [23, 24]}}
{"token": ["Although", "not", "absolutely", "required", "for", "C0004135#ent", "<e1>", "activation", ",", "the", "C0597094#ent", "<e2>", "may", "help", "reach", "the", "threshold", "activity", "of", "C0004135#ent", "<e1>", "necessary", "for", "optimal", "genome", "maintenance", "and", "prevention", "of", "cancer", "."], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [5, 6]}}
{"token": ["A", "decreased", "efficiency", "of", "C1332701#ent", "<e1>", "to", "work", "as", "decoy", "receptor", "C1336646#ent", "<e2>", ",", "would", "facilitate", "the", "apoptotic", "pathway", "cells", "at", "risk", "."], "h": {"id": "C1332701", "name": "C1332701#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336646", "name": "C1336646#ent", "pos": [11, 12]}}
{"token": ["The", "case", "is", "presented", "of", "C0027726#ent", "<e1>", "in", "the", "form", "of", "C0950121#ent", "<e2>"], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0950121", "name": "C0950121#ent", "pos": [11, 12]}}
{"token": ["Similarity", "of", "C0154830#ent", "<e1>", "to", "the", "C0014442#ent", "<e2>", "of", "the", "glutathione", "reductase", "family", "discussed", "."], "h": {"id": "C0154830", "name": "C0154830#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}}
{"token": ["Eighty", "kDa", "preparation", "supported", "the", "metabolism", "of", "aminopyrine", "and", "C0724709#ent", "<e1>", "by", "hepatic", "P4502C", "and", "erythromycin", ",", "ethylmorphine", "and", "C0028066#ent", "<e2>", "by", "hepatic", "P450", "3A", ",", "respectively", "."], "h": {"id": "C0724709", "name": "C0724709#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [19, 20]}}
{"token": ["We", "identified", "three", "children", "with", "mendelian", "susceptibility", "C0026918#ent", "<e1>", "were", "homozygous", "with", "respect", "to", "a", "missense", "mutation", "C1334084#ent", "<e2>", "creating", "a", "new", "N-glycosylation", "site", "the", "IFNgammaR2", "chain", "."], "h": {"id": "C0026918", "name": "C0026918#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C1334084", "name": "C1334084#ent", "pos": [17, 18]}}
{"token": ["Activation", "of", "primary", "afferent", "C-fibers", "by", "repeated", "intrathecal", "injection", "of", "C0022471#ent", "<e1>", "KA", ")", "in", "mice", "is", "inhibited", "after", "pretreatment", "with", "C0006931#ent", "<e2>", "."], "h": {"id": "C0022471", "name": "C0022471#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [21, 22]}}
{"token": ["A", "period", "of", "direct", "contact", "with", "a", "concentration", "of", "20", "mug/ml", "or", "less", "of", "either", "famotine", "(", "C0950996#ent", "<e1>", "or", "memotine", "(", "1-(p-methoxyphenoxymethyl)-3,4-dihydroisoquinoline", "C0546849#ent", "<e2>", ")", "inactivates", "myxoviruses", "and", "paramyxoviruses", "."], "h": {"id": "C0950996", "name": "C0950996#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0546849", "name": "C0546849#ent", "pos": [23, 24]}}
{"token": ["In", "these", "two", "C0011860#ent", "<e1>", "models", ",", "several", "common", "alterations", "in", "glucose-induced", "C1413043#ent", "<e2>", "+", "handling", "were", "revealed", "which", "may", "contribute", "to", "their", "poor", "glucose-induced", "insulin", "secretion"], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [12, 13]}}
{"token": ["Conversely", ",", "U0126", ",", "a", "C0169101#ent", "<e1>", "inhibitor", ",", "and", "C0672708#ent", "<e2>", "or", "SBHA", ",", "2", "histone", "deacetylase", "inhibitors", "reduced", "the", "expression", "of", "involucrin", "during", "calcium-induced", "stratification", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0672708", "name": "C0672708#ent", "pos": [10, 11]}}
{"token": ["A", "58-year-old", "male", "presented", "with", "reversible", "C3160858#ent", "<e1>", "RPLS", ")", "manifesting", "as", "headache", ",", "papilledema", ",", "and", "C0020544#ent", "<e2>"], "h": {"id": "C3160858", "name": "C3160858#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020544", "name": "C0020544#ent", "pos": [17, 18]}}
{"token": ["The", "highly", "lipid-soluble", "opioids", ",", "fentanyl", "and", "C0162792#ent", "<e1>", ",", "frequently", "are", "used", "in", "combination", "with", "local", "C0017302#ent", "<e2>", "epinephrine", "to", "provide", "postoperative", "epidural", "analgesia"], "h": {"id": "C0162792", "name": "C0162792#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017302", "name": "C0017302#ent", "pos": [17, 18]}}
{"token": ["The", "hemodynamic", "response", "of", "lambs", "to", "injections", "of", "oleic", "acid", "was", "compared", "to", "their", "response", "after", "pretreatment", "with", "either", "FPL57231", ",", "a", "C0595726#ent", "<e1>", "or", "indomethacin", ",", "a", "C1565830#ent", "<e2>", "inhibitor", "."], "h": {"id": "C0595726", "name": "C0595726#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [28, 29]}}
{"token": ["As", "cord", "blood", "lymphocytes", "be", "induced", "to", "differentiate", "into", "effector", "cells", "predominantly", "C1423842#ent", "<e1>", "or", "Th2", "cytokines", ",", "C0024530#ent", "<e2>", "during", "pregnancy", "might", "direct", "the", "functional", "capacity", "of", "fetal", "T", "cells", "respond", "to", "further", "infection", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [18, 19]}}
{"token": ["C0678046#ent", "<e1>", "similarly", "improved", "the", "effectiveness", "of", "cisplatin", "in", "producing", "C0043891#ent", "<e2>", "when", "screened", "against", "the", "SD", "human", "neuroblastoma", "xenograft", "."], "h": {"id": "C0678046", "name": "C0678046#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0043891", "name": "C0043891#ent", "pos": [10, 11]}}
{"token": ["High", "constitutive", "levels", "of", "IL-18", "may", "contribute", "to", "the", "skewing", "towards", "a", "C3537293#ent", "<e1>", "environment", ",", "which", "is", "apparent", "in", "many", "human", "C1290884#ent", "<e2>"], "h": {"id": "C3537293", "name": "C3537293#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [22, 23]}}
{"token": ["The", "intact", "and", "cleaved", "forms", "of", "C1332668#ent", "<e1>", "increased", "in", "diabetic", "rat", "C0032002#ent", "<e2>", "compared", "with", "controls", "."], "h": {"id": "C1332668", "name": "C1332668#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [12, 13]}}
{"token": ["We", "found", "profound", "and", "persistent", "C0206744#ent", "<e1>", "all", "but", "one", "studied", "patients", "after", "C1275685#ent", "<e2>", "treatment", "."], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1275685", "name": "C1275685#ent", "pos": [13, 14]}}
{"token": ["We", "show", "also", "that", "the", "regulation", "of", "C0031644#ent", "<e1>", "by", "PPARs", "is", "C1332691#ent", "<e2>", "and", "isotype-specific", "since", "rosiglitazone", "induces", "C0031644#ent", "<e1>", "gene", "expression", "in", "adipocytes", ",", "and", "PPARalpha-", "and", "PPARbeta-specific", "activators", "are", "inefficient", "."], "h": {"id": "C0031644", "name": "C0031644#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [12, 13]}}
{"token": ["Cleavage", "of", "C1538577#ent", "<e1>", "degradation", "of", "C1332695#ent", "<e2>", "events", "that", "are", "known", "to", "be", "associated", "with", "apoptosis", ",", "were", "also", "observed", "following", "overexpression", "of", "p27Kip1", "."], "h": {"id": "C1538577", "name": "C1538577#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332695", "name": "C1332695#ent", "pos": [6, 7]}}
{"token": ["Here", "we", "show", "that", "C1706435#ent", "<e1>", "activates", "the", "C0082529#ent", "<e2>", "ERK", ")", "pathway", "and", "that", "the", "kinase", "activity", "C1706435#ent", "<e1>", "appears", "to", "be", "important", "in", "this", "process", "."], "h": {"id": "C1706435", "name": "C1706435#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [8, 9]}}
{"token": ["This", "C0039082#ent", "<e1>", "should", "be", "distinguished", "from", "the", "C0242292#ent", "<e2>", "as", "it", "is", "reversible", "with", "thyroid", "replacement", "therapy"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0242292", "name": "C0242292#ent", "pos": [8, 9]}}
{"token": ["C3541309#ent", "<e1>", "was", "identified", "in", "31.7", "%", "of", "C0012833#ent", "<e2>", "patients", "vs", "24", "%", "of", "control", "subjects"], "h": {"id": "C3541309", "name": "C3541309#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012833", "name": "C0012833#ent", "pos": [8, 9]}}
{"token": ["The", "compounds", "have", "been", "evaluated", "with", "in", "vitro", "cellular", "assays", "measure", "the", "ability", "of", "the", "C1709384#ent", "<e1>", "inhibitors", "to", "enhance", "the", "effect", "of", "C0304497#ent", "<e2>", "cancer", "cell", "lines"], "h": {"id": "C1709384", "name": "C1709384#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0304497", "name": "C0304497#ent", "pos": [23, 24]}}
{"token": ["The", "binding", "studies", "between", "C1413001#ent", "<e1>", "and", "protein", "S", "performed", "on", "C0034861#ent", "<e2>", "mutations", "had", "been", "introduced", "."], "h": {"id": "C1413001", "name": "C1413001#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [11, 12]}}
{"token": ["CSA", "is", "dispensable", "for", "attraction", "of", "NER", "proteins", "yet", "in", "cooperation", "with", "C1707866#ent", "<e1>", "is", "required", "to", "recruit", "XAB2", ",", "the", "nucleosomal", "binding", "protein", "C1333912#ent", "<e2>", "and", "TFIIS", "."], "h": {"id": "C1707866", "name": "C1707866#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333912", "name": "C1333912#ent", "pos": [24, 25]}}
{"token": ["In", "the", "present", "study", ",", "the", "dietary", "fatty", "acids", "FA", ")", ",", "phytanic", "acid", "PA", ")", ",", "and", "docosahexaenoic", "acid", "C1415467#ent", "<e1>", ")", "have", "been", "used", "as", "substrates", "for", "C1259497#ent", "<e2>", "UGTs", ")", "."], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1259497", "name": "C1259497#ent", "pos": [29, 30]}}
{"token": ["Incorporation", "of", "C0044549#ent", "<e1>", "into", "well-characterized", "liposomes", "known", "as", "C1313443#ent", "<e2>", "has", "eliminated", "its", "gastrointestinal", "and", "hemolytic", "toxicity", "without", "loss", "of", "growth", "inhibiting", "activity", "."], "h": {"id": "C0044549", "name": "C0044549#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1313443", "name": "C1313443#ent", "pos": [9, 10]}}
{"token": ["Association", "of", "the", "ether", "lipid", "C0044549#ent", "<e1>", "(", "ET-18-OCH3", ")", "with", "liposomes", "(", "C1313443#ent", "<e2>", ")", "reduces", "acute", "toxicity", "while", "maintaining", "or", "enhancing", "anticancer", "activity", "in", "experimental", "tumor", "models", "."], "h": {"id": "C0044549", "name": "C0044549#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1313443", "name": "C1313443#ent", "pos": [13, 14]}}
{"token": ["NAFLD", "(", "non-alcoholic", "fatty", "liver", "disease", "encompasses", "the", "spectrum", "of", "C2711227#ent", "<e1>", "insulin-resistant", "individuals", "who", "often", "display", "T2DM", "(", "C0011854#ent", "<e2>", "and", "obesity", "."], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [19, 20]}}
{"token": ["C2711227#ent", "<e1>", "rare", "in", "C0011854#ent", "<e2>", "patients", "and", "is", "indicative", "of", "a", "poor", "diabetic", "control", "."], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [4, 5]}}
{"token": ["It", "has", "been", "suggested", ",", "although", "not", "confirmed", ",", "that", "deficiency", "in", "C0030946#ent", "<e1>", "inhibiting", "capacity", "could", "be", "correlated", "with", "susceptibility", "to", "C0031090#ent", "<e2>"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0031090", "name": "C0031090#ent", "pos": [22, 23]}}
{"token": ["Transforming", "growth", "factor", "beta", "C1366557#ent", "<e1>", ")", "belongs", "to", "a", "family", "of", "C1305923#ent", "<e2>", "diverse", "biological", "functions"], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}}
{"token": ["C1366557#ent", "<e1>", "TGB-beta", "1", ")", "belongs", "to", "a", "family", "of", "C1305923#ent", "<e2>", "with", "regulatory", "effects", "growth", "and", "differentiation", "of", "a", "variety", "of", "cell", "types"], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [10, 11]}}
{"token": ["The", "degree", "of", "C2347054#ent", "<e1>", "staining", "was", "less", "marked", "than", "that", "of", "C1415042#ent", "<e2>", "in", "examined", "fetal", "cases", "."], "h": {"id": "C2347054", "name": "C2347054#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415042", "name": "C1415042#ent", "pos": [12, 13]}}
{"token": ["Effects", "of", "dexamethasone", "(", "DEX", ")", "on", "the", "relative", "abundance", "of", "myelin", "basic", "protein", "C2347054#ent", "<e1>", ")", ",", "proteolipid", "protein", "PLP", ")", "and", "glial", "fibrillary", "acidic", "protein", "C1415042#ent", "<e2>", ")", "mRNAs", "in", "the", "developing", "rat", "brain", "were", "examined", "."], "h": {"id": "C2347054", "name": "C2347054#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1415042", "name": "C1415042#ent", "pos": [27, 28]}}
{"token": ["Of", "these", ",", "the", "C1333183#ent", "<e1>", "cdk2", "were", "significantly", "C3889446#ent", "<e2>", "in", "comparison", "with", "levels", "in", "proliferating", ",", "undifferentiated", "myoblasts", "."], "h": {"id": "C1333183", "name": "C1333183#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [9, 10]}}
{"token": ["In", "the", "treatment", "of", "C0024131#ent", "<e1>", "GLN", ",", "several", "therapeutic", "approaches", "all", "including", "immunosuppressive", "drugs", "such", "as", "C1161438#ent", "<e2>", ",", "azathioprine", ",", "or", "cyclosporine", "A", "have", "been", "used", "."], "h": {"id": "C0024131", "name": "C0024131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [17, 18]}}
{"token": ["The", "results", "presented", "here", "demonstrate", "that", "a", "replication-defective", "murine", "retrovirus", "expressing", "the", "human", "C1420874#ent", "<e1>", "abrogate", "the", "C0812325#ent", "<e2>", "requirements", "of", "hematopoietic", "cells", "a", "non-autocrine", "mechanism", "."], "h": {"id": "C1420874", "name": "C1420874#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [17, 18]}}
{"token": ["These", "data", "suggest", "a", "therapeutic", "potential", "for", "C0700478#ent", "<e1>", "in", "obstructive", "sleep-disordered", "breathing", "particularly", "C0520680#ent", "<e2>"], "h": {"id": "C0700478", "name": "C0700478#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0520680", "name": "C0520680#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "the", "mechanism", "of", "C0009325#ent", "<e1>", "deposition", "in", "CAN", ",", "we", "studied", "the", "effects", "of", "prolyl-hydroxylase", "inhibitor", "C2975867#ent", "<e2>", ")", ",", "an", "enzyme", "essential", "for", "C0009325#ent", "<e1>", "formation", ",", "using", "a", "mouse", "model", "kidney", "transplantation"], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [5, 6]}}
{"token": ["Forty-six", "C0028309#ent", "<e1>", "significant", "quantities", "of", "bone-resorbing", "prostaglandins", "(", "C0796254#ent", "<e2>", ")", "in", "tissue", "culture"], "h": {"id": "C0028309", "name": "C0028309#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [9, 10]}}
{"token": ["Receptor", "binding", "biological", "action", "insulin", "and", "insulin-like", "growth", "factor", "I", "IGF-I", ")", "were", "studied", "in", "fibroblasts", "from", "a", "patient", "with", "C0265344#ent", "<e1>", "and", "a", "patient", "with", "C0039082#ent", "<e2>", "insulin", "resistance"], "h": {"id": "C0265344", "name": "C0265344#ent", "pos": [20, 21]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [26, 27]}}
{"token": ["There", "was", "a", "significant", "treatment", "difference", "in", "C0018802#ent", "<e1>", "hospitalisations", "(", "candesartan", "C0527379#ent", "<e2>", ":", "3.0", "%", "vs.", "placebo", ":", "5.6", "%", ")", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0527379", "name": "C0527379#ent", "pos": [12, 13]}}
{"token": ["An", "inhibitor", "of", "p38", "MAPK", "phosphorylation", "(", "C0291985#ent", "<e1>", ")", "partially", "reversed", "the", "effects", "of", "the", "C0013604#ent", "<e2>", "net", "fluid", "transport", "well", "as", "gene", "and", "protein", "expression", "the", "main", "ion", "transporters"], "h": {"id": "C0291985", "name": "C0291985#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [16, 17]}}
{"token": ["Virtually", "all", "areas", "containing", "neurons", "positive", "for", "C1419595#ent", "<e1>", "also", "expressed", "C1704920#ent", "<e2>", ",", "whereas", "many", "Y1-positive", "cells", "clearly", "did", "not", "express", "C1419595#ent", "<e1>", "."], "h": {"id": "C1704920", "name": "C1704920#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419595", "name": "C1419595#ent", "pos": [7, 8]}}
{"token": ["Additionally", "factors", "including", "the", "Brahma-related", "gene", "1", "C1706022#ent", "<e1>", ")", "that", "are", "involved", "in", "the", "structural", "remodeling", "C0008546#ent", "<e2>", "also", "mediate", "hormone-dependent", "transcriptional", "activation", "by", "nuclear", "receptors"], "h": {"id": "C1706022", "name": "C1706022#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [17, 18]}}
{"token": ["The", "atypical", "character", "of", "the", "skin", "lesions", "the", "patient", "presented", "here", "incites", "to", "discuss", "the", "nosological", "relationship", "Sweet's", "syndrome", "C0034212#ent", "<e1>", "an", "entity", "closely", "associated", "with", "C0178650#ent", "<e2>", "."], "h": {"id": "C0034212", "name": "C0034212#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0178650", "name": "C0178650#ent", "pos": [26, 27]}}
{"token": ["These", "observations", "may", "be", "relevant", "for", "our", "understanding", "of", "GVH", "reactions", ",", "of", "C0021053#ent", "<e1>", "associated", "with", "GVH", ",", "and", "possibly", "of", "primary", "and", "acquired", "C0021051#ent", "<e2>", "in", "general", "."], "h": {"id": "C0021053", "name": "C0021053#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0021051", "name": "C0021051#ent", "pos": [25, 26]}}
{"token": ["Our", "study", "addresses", "relationships", "between", "chromosomal", "aberrations", "CAs", ")", ",", "chromosome", "(", "C0751039#ent", "<e1>", ")", ",", "and", "chromatid", "(", "C3540513#ent", "<e2>", ")", "types", "and", "polymorphisms", "in", "DNA", "repair", "genes", "XRCC1", "and", "XRCC3", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3540513", "name": "C3540513#ent", "pos": [19, 20]}}
{"token": ["Similarly", ",", "p22phox", "(", "P156Q", ")", ",", "a", "mutation", "that", "disrupts", "Src", "homology", "3", "binding", "by", "the", "PRR", ",", "potently", "inhibited", "reactive", "oxygen", "production", "C1418951#ent", "<e1>", "and", "Nox2", "but", "not", "from", "Nox4", "and", "C0003693#ent", "<e2>", "."], "h": {"id": "C1418951", "name": "C1418951#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0003693", "name": "C0003693#ent", "pos": [33, 34]}}
{"token": ["RTN1", "and", "C1419770#ent", "<e1>", "belong", "to", "the", "reticulon", "(", "RTN", ")", "C1335597#ent", "<e2>", "which", "are", "primarily", "expressed", "in", "the", "endoplasmic", "reticulum"], "h": {"id": "C1419770", "name": "C1419770#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335597", "name": "C1335597#ent", "pos": [11, 12]}}
{"token": ["C1538837#ent", "<e1>", "and", "CT301", "(", "encoding", "C0252902#ent", "<e2>", "and", "PknD", ",", "respectively", ")", "were", "expressed", "in", "Escherichia", "coli", "GST", "fusion", "proteins"], "h": {"id": "C1538837", "name": "C1538837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0252902", "name": "C0252902#ent", "pos": [6, 7]}}
{"token": ["These", "results", "confirm", "and", "extend", "previous", "observations", "about", "the", "anti-inflammatory", "effects", "androgen", "therapy", "C1456795#ent", "<e1>", "in", "a", "new", ",", "previously", "unexplored", "model", "of", "C0039585#ent", "<e2>", "namely", ",", "aging", "type-2", "diabetic", "men", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0039585", "name": "C0039585#ent", "pos": [23, 24]}}
{"token": ["In", "a", "second", "step", "visual", "fields", "C0005742#ent", "<e1>", "were", "compared", "with", "those", "in", "C0005745#ent", "<e2>", "."], "h": {"id": "C0005742", "name": "C0005742#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [13, 14]}}
{"token": ["However", ",", "immediately", "after", "C0812380#ent", "<e1>", "exposure", ",", "immunohistochemistry", "revealed", "increased", "staining", "for", "C0059735#ent", "<e2>", "in", "airway", "epithelia", "and", "lung", "parenchyma", "following", "recovery", "in", "air", ",", "the", "staining", "disappeared", "again", "."], "h": {"id": "C0812380", "name": "C0812380#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [13, 14]}}
{"token": ["C0002170#ent", "<e1>", "is", "a", "C0037274#ent", "<e2>", "psychosocial", "implications", "on", "patients", "with", "hair", "loss"], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [4, 5]}}
{"token": ["Using", "co-sedimentation", "and", "co-immunoprecipitation", "we", "have", "defined", "a", "macromolecular", "complex", "of", "RyR2", ",", "C1414619#ent", "<e1>", ",", "PKA", ",", "the", "C0031686#ent", "<e2>", "PP1", "and", "PP2A", ",", "and", "an", "anchoring", "protein", "mAKAP", "."], "h": {"id": "C1414619", "name": "C1414619#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [19, 20]}}
{"token": ["Previously", "we", "found", "that", "the", "amino-terminal", "region", "the", "C0028326#ent", "<e1>", "influenza", "A", "virus", "a", "key", "role", "in", "preventing", "the", "induction", "of", "C0751599#ent", "<e2>", "IFN-beta", ")", "in", "virus-infected", "cells", "."], "h": {"id": "C0028326", "name": "C0028326#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0751599", "name": "C0751599#ent", "pos": [21, 22]}}
{"token": ["A", "fragment", "corresponding", "to", "the", "homeodomain", "region", "KNAP1", "was", "used", "to", "C1875400#ent", "<e1>", "a", "cDNA", "(", "KNAP3", ")", "belonging", "to", "the", "C1422043#ent", "<e2>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422043", "name": "C1422043#ent", "pos": [21, 22]}}
{"token": ["We", "conclude", "that", "nerve", "growth", "factor", "brain-derived", "neurotrophic", "factor", "not", "C2984225#ent", "<e1>", "expression", "are", "inhibited", "by", "C3887648#ent", "<e2>", ",", "arising", "from", "the", "locus", "coeruleus"], "h": {"id": "C2984225", "name": "C2984225#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [16, 17]}}
{"token": ["C0563238#ent", "<e1>", "is", "a", "common", "finding", "in", "patients", "with", "C0021390#ent", "<e2>"], "h": {"id": "C0563238", "name": "C0563238#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [9, 10]}}
{"token": ["Since", "monocytes", "are", "an", "important", "source", "of", "the", "chemoattractant", "cytokine", "C1366571#ent", "<e1>", ",", "we", "studied", "the", "effects", "of", "C0879590#ent", "<e2>", "on", "the", "expression", "of", "C1366571#ent", "<e1>", "in", "human", "monocytes", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [10, 11]}}
{"token": ["A", "55-year-old", "man", "with", "a", "subacute", "onset", "of", "slurred", "speech", "ataxia", ",", "nystagmus", ",", "extrapyramidal", "rigidity", "decreased", "tendon", "reflexes", "vomiting", ",", "C0029124#ent", "<e1>", "and", "clonic", "jerks", "died", "of", "C0006285#ent", "<e2>", "and", "respiratory", "failure"], "h": {"id": "C0029124", "name": "C0029124#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0006285", "name": "C0006285#ent", "pos": [28, 29]}}
{"token": ["RED2", "further", "differs", "from", "C3812251#ent", "<e1>", "in", "having", "a", "54-residue", "amino-terminal", "extension", "which", "includes", "an", "C1332114#ent", "<e2>"], "h": {"id": "C3812251", "name": "C3812251#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332114", "name": "C1332114#ent", "pos": [15, 16]}}
{"token": ["Although", "intradermal", "injection", "of", "capsaicin", "produces", "C0184567#ent", "<e1>", "secondary", "hyperalgesia", ",", "long-term", "topical", "application", "of", "C0006931#ent", "<e2>", "been", "used", "as", "a", "medication", "for", "pain", "relief", "various", "pain", "conditions"], "h": {"id": "C0184567", "name": "C0184567#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0006931", "name": "C0006931#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "evaluate", "the", "presence", "of", "aCL", "in", "cerebrospinal", "fluid", "CSF", ")", "in", "C0024141#ent", "<e1>", "patients", "with", "C1706141#ent", "<e2>", "features", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1706141", "name": "C1706141#ent", "pos": [22, 23]}}
{"token": ["C1334032#ent", "<e1>", ",", "a", "member", "of", "the", "C1333891#ent", "<e2>", "is", "involved", "in", "transcription", "regulation", "through", "the", "modification", "of", "chromatin", "structure"], "h": {"id": "C1334032", "name": "C1334032#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [7, 8]}}
{"token": ["C0073237#ent", "<e1>", "an", "essential", "C1333398#ent", "<e2>", "in", "the", "turnover", "of", "messenger", "RNA", "the", "maturation", "of", "structured", "RNA", "precursors", "in", "Escherichia", "coli"], "h": {"id": "C0073237", "name": "C0073237#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333398", "name": "C1333398#ent", "pos": [4, 5]}}
{"token": ["He", "presented", "with", "C0000737#ent", "<e1>", "constipation", ",", "subsequently", "developed", "status", "epilepticus", "C0264490#ent", "<e2>", "quadriparesis", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "a", "60-year-old", "male", "patient", "with", "acute", "intermittent", "porphyria", "AIP", ")", "who", "presented", "with", "initial", "C0000737#ent", "<e1>", "subsequent", "quadriplegia", "and", "C0264490#ent", "<e2>"], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0264490", "name": "C0264490#ent", "pos": [21, 22]}}
{"token": ["C0145108#ent", "<e1>", "is", "a", "veterinary", "anesthetic", "agent", "is", "composed", "of", "equal", "parts", "of", "C0040217#ent", "<e2>", "and", "zolazepam", "."], "h": {"id": "C0145108", "name": "C0145108#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040217", "name": "C0040217#ent", "pos": [13, 14]}}
{"token": ["C0127082#ent", "<e1>", "MMPs", ")", "are", "C1142638#ent", "<e2>", "have", "been", "implicated", "in", "the", "malignancy", "of", "gliomas", "."], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1142638", "name": "C1142638#ent", "pos": [5, 6]}}
{"token": ["We", "find", "that", "it", "might", "be", "worthwhile", "to", "evaluate", "whether", "C0162820#ent", "<e1>", "compounds", "other", "than", "C3540725#ent", "<e2>", "may", "be", "easier", "to", "detect", "with", "intradermal", "than", "patch", "test"], "h": {"id": "C0162820", "name": "C0162820#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540725", "name": "C3540725#ent", "pos": [15, 16]}}
{"token": ["Conversely", ",", "cells", "taking", "up", "C1417679#ent", "<e1>", "that", "elevate", "C0082645#ent", "<e2>", "levels", "remained", "mesenchymal", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "H-Ras", "V12", "downregulated", "by", ">", "eightfold", "52", "C1417679#ent", "<e1>", "compared", "to", "only", "three", "C1417679#ent", "<e1>", "by", "RhoA", "QL", ",", "Rac1", "QL", "and", "C0082645#ent", "<e1>", "QL", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0082645", "name": "C0082645#ent", "pos": [24, 25]}}
{"token": ["Stripping", "the", "C0751995#ent", "<e1>", "proteins", "or", "incubating", "one-layer", "SIS", "with", "neutralizing", "antibodies", "basic", "fibroblast", "growth", "factor", "C1522505#ent", "<e2>", ")", "or", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "resulted", "in", "decreased", "angiogenesis", "."], "h": {"id": "C0751995", "name": "C0751995#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522505", "name": "C1522505#ent", "pos": [16, 17]}}
{"token": ["induce", "the", "expression", "of", "C1415652#ent", "<e1>", "in", "vitro", "and", "proatherogenic", "conditions", ",", "e.g.", ",", "hypertension", ",", "hyperlipidemia", ",", "and", "C0011849#ent", "<e2>", ",", "induce", "the", "expression", "of", "C1415652#ent", "<e1>", "in", "vivo"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415652", "name": "C1415652#ent", "pos": [4, 5]}}
{"token": ["BMP-9", "bound", "with", "high", "affinity", "to", "C1366565#ent", "<e1>", "and", "endoglin", ",", "and", "weakly", "to", "the", "type-I", "receptor", "C1704931#ent", "<e2>", "and", "to", "the", "BMP", "type-II", "receptor", "BMPR-II", ")", "and", "activin", "type-II", "receptor", "ActR-II", ")", "in", "transfected", "COS", "cells"], "h": {"id": "C1366565", "name": "C1366565#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704931", "name": "C1704931#ent", "pos": [17, 18]}}
{"token": ["The", "syndrome-causing", "gene", "encodes", "the", "X-linked", "E3", "ubiquitin", "ligase", "MID1", "that", "mediates", "C0669472#ent", "<e1>", "degradation", "of", "the", "catalytic", "subunit", "the", "translation", "regulator", "protein", "phosphatase", "2A", "C1704708#ent", "<e2>", ")", "."], "h": {"id": "C0669472", "name": "C0669472#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704708", "name": "C1704708#ent", "pos": [25, 26]}}
{"token": ["Thus", ",", "the", "aim", "of", "this", "study", "was", "to", "investigate", "the", "expressivity", "of", "C1704467#ent", "<e1>", ",", "bax", "and", "C1366837#ent", "<e2>", "in", "the", "rat", "tongue", "mucosa", "exposed", "to", "cigarette", "smoke", "means", "of", "immunohistochemistry", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [18, 19]}}
{"token": ["Although", "general", "blockade", "of", "CCL5", "receptors", "reduces", "C0004153#ent", "<e1>", ",", "specific", "roles", "of", "C1332699#ent", "<e2>", "and", "CCR5", "have", "not", "been", "unequivocally", "determined", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1332699", "name": "C1332699#ent", "pos": [13, 14]}}
{"token": ["Neither", "C0002561#ent", "<e1>", "a", "system", "A-specific", "substrate", ")", "nor", "C0045875#ent", "<e2>", "a", "system", "L-specific", "substrate", ")", "inhibited", "the", "uptake", "of", "L-[(3)H]serine", "in", "both", "neurons", "and", "astrocytes", "."], "h": {"id": "C0002561", "name": "C0002561#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0045875", "name": "C0045875#ent", "pos": [9, 10]}}
{"token": ["C0018312#ent", "<e1>", "'", "in", "vitro", "inhibits", "pig", "plasma", "C0005105#ent", "<e2>", "a", "IC50", "M", "+", "/-", "0.8", "X", "10(-6", ")", "M.", "It", "also", "inhibits", "pig", "kidney", "diamine", "oxidase", "rat", "liver", "mitochondrial", "monoamine", "oxidase", "higher", "concentrations", "."], "h": {"id": "C0018312", "name": "C0018312#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005105", "name": "C0005105#ent", "pos": [8, 9]}}
{"token": ["Because", "neither", "C0002245#ent", "<e1>", "nor", "C4283740#ent", "<e2>", "has", "been", "localized", "to", "the", "nuclear", "envelope", "intranuclear", "sites", "C0002245#ent", "<e1>", "and", "C4283740#ent", "<e2>", "activites", "were", "measured", "in", "rat", "liver", "nuclei", "and", "nuclear", "reformation", "extracts", "."], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [2, 3]}}
{"token": ["As", "a", "serine-threonine", "protein", "kinase", "glycogen", "synthase", "kinase-3", "C4283740#ent", "<e1>", ")", "regulates", "the", "synthesis", "of", "C0002245#ent", "<e2>", "and", "plays", "important", "roles", "in", "several", "signaling", "pathways"], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002245", "name": "C0002245#ent", "pos": [15, 16]}}
{"token": ["Potassium", "and", "C3714642#ent", "<e1>", "ion-selective", "microelectrodes", "used", "in", "vitro", "investigate", "the", "depolarization", "of", "skeletal", "muscle", "fibers", "associated", "with", "C0026850#ent", "<e2>"], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026850", "name": "C0026850#ent", "pos": [18, 19]}}
{"token": ["Pharmacologic", "manipulation", "C1958958#ent", "<e1>", "levels", "may", "provide", "a", "novel", "therapeutic", "approach", "C0029896#ent", "<e2>", "that", "represent", "the", "most", "common", "causes", "of", "mortality", "in", "Western", "society", "including", "cancer", ",", "chronic", "lung", "disease", "and", "myocardial", "ischemia"], "h": {"id": "C1958958", "name": "C1958958#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [11, 12]}}
{"token": ["C0012634#ent", "<e1>", "of", "newborns", "infected", "by", "Chlamydia", "trachomatis", "inclusion", "conjunctivitis", "infant", "C0339959#ent", "<e2>"], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0339959", "name": "C0339959#ent", "pos": [11, 12]}}
{"token": ["The", "genes", "involved", "in", "bacilysin", "biosynthesis", "identified", "as", "thyA", "(", "C1366824#ent", "<e1>", ",", "ybgG", "(", "unknown", ";", "similar", "to", "C0062934#ent", "<e2>", "and", "oppA", "(", "oligopeptide", "permease", ",", "respectively", "."], "h": {"id": "C1366824", "name": "C1366824#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0062934", "name": "C0062934#ent", "pos": [19, 20]}}
{"token": ["Downstream", "of", "mitogen-activated", "protein", "kinases", "MAPKs", ")", ",", "three", "structurally", "related", "C1431394#ent", "<e1>", "MAPKAPKs", "or", "MKs", ")", "-", "MK2", ",", "MK3", "and", "C1417029#ent", "<e2>", "-", "signal", "to", "diverse", "cellular", "targets"], "h": {"id": "C1431394", "name": "C1431394#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417029", "name": "C1417029#ent", "pos": [22, 23]}}
{"token": ["The", "C1110602#ent", "<e1>", "ether-soluble", "fraction", "ofE.", "crassipes", "induced", "high", "weevil", "C1412696#ent", "<e2>", "in", "all", "methods", "employed", "."], "h": {"id": "C1110602", "name": "C1110602#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412696", "name": "C1412696#ent", "pos": [10, 11]}}
{"token": ["Expression", "of", "the", "PKCepsilon", "inhibitor", "inhibited", "C1321914#ent", "<e1>", "APPs", "secretion", "and", "suppression", "of", "C1705543#ent", "<e2>", "production", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705543", "name": "C1705543#ent", "pos": [13, 14]}}
{"token": ["One", "subtracted", "C0079429#ent", "<e1>", "that", "showed", "the", "Abeta-induced", "expression", "was", "rat", "C4255123#ent", "<e2>", "(", "a", "disintegrin", "and", "metalloproteinase", "with", "thrombospondin", "motifs", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4255123", "name": "C4255123#ent", "pos": [11, 12]}}
{"token": ["Two", "mutations", "resulting", "in", "C0669365#ent", "<e1>", "expression", "of", "glucose-repressible", "functions", ",", "C1417167#ent", "<e2>", "and", "reg1", ",", "resulted", "in", "C0669365#ent", "<e1>", "expression", "of", "high-affinity", "glucose", "uptake"], "h": {"id": "C1417167", "name": "C1417167#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [4, 5]}}
{"token": ["C0042679#ent", "<e1>", "induces", "depolymerization", "of", "microtubules+", ",", "appearance", "of", "crystalloid", "structures", "platelet", "cytoplasm", "C2712370#ent", "<e2>", "the", "biogenesis", "of", "lysosomal", "enzymes", "for", "the", "first", "time", "the", "activity", "of", "acid", "phosphatase", "been", "shown", "in", "cisterns", "of", "the", "dense", "tubular", "system"], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [13, 14]}}
{"token": ["These", "are", "known", "collectively", "as", "the", "extraesophageal", "manifestations", "of", "GERD", ",", "such", "as", "non-cardiac", "chest", "pain", "laryngitis", ",", "C0744898#ent", "<e1>", "hoarseness", ",", "asthma", "or", "C3887524#ent", "<e2>"], "h": {"id": "C0744898", "name": "C0744898#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3887524", "name": "C3887524#ent", "pos": [24, 25]}}
{"token": ["Our", "results", "suggest", "that", "PKC", "activation", "enhanced", "C1706331#ent", "<e1>", "fibrillogenesis", ",", "whereas", "C0010531#ent", "<e2>", "activation", "inhibited", "extracellular", "C1706331#ent", "<e1>", "fibrillogenesis", "in", "primary", "cultured", "osteoblasts", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [7, 8]}}
{"token": ["Although", "the", "alpha", "2", "beta", "1", "be", "activated", "by", "several", "intracellular", "second", "messengers", ",", "including", "C0010531#ent", "<e1>", "intracellular", "calcium", ",", "the", "potentiating", "effect", "of", "C1706331#ent", "<e2>", "was", "mediated", "only", "by", "PKC", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [24, 25]}}
{"token": ["Sequencing", "of", "genomic", "polymerase", "chain", "reaction", "PCR", ")", "products", "synthesized", "using", "primers", "generated", "from", "the", "C1413873#ent", "<e1>", "and", "CYP2C9", "cDNAs", "revealed", "the", "presence", "of", "a", "new", "C1378702#ent", "<e2>", "the", "human", "genome", "."], "h": {"id": "C1413873", "name": "C1413873#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1378702", "name": "C1378702#ent", "pos": [26, 27]}}
{"token": ["We", "present", "evidence", "that", "C1537933#ent", "<e1>", "is", "involved", "in", "trafficking", "of", "C1456396#ent", "<e2>", ",", "the", "major", "mammalian", "iron", "exporter", "to", "the", "surface", "of", "iron-recycling", "macrophages", "."], "h": {"id": "C1537933", "name": "C1537933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1456396", "name": "C1456396#ent", "pos": [11, 12]}}
{"token": ["A", "two-generation", "consanguineous", "Pakistani", "family", "autosomal", "recessive", "Leber", "congenital", "amaurosis", "C1413510#ent", "<e1>", ",", "MIM", "204,000", ")", "and", "C0022578#ent", "<e2>", "was", "identified", "."], "h": {"id": "C1413510", "name": "C1413510#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022578", "name": "C0022578#ent", "pos": [17, 18]}}
{"token": ["Out", "of", "the", "50", "selected", "cases", ",", "survival", "analysis", "done", "for", "comparison", "of", "the", "C0036421#ent", "<e1>", "period", "and", "the", "clinical", "factors", "associated", "with", "ANCA-associated", "vasculitis", "C1412056#ent", "<e2>", ")", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412056", "name": "C1412056#ent", "pos": [25, 26]}}
{"token": ["C1417679#ent", "<e1>", "encoding", "the", "C1414910#ent", "<e2>", "beta2", ",", "beta3", ",", "epsilon", ",", "and", "pi", "subunits", "as", "well", "as", "the", "GABA(B", ")", "receptor", "1", "subunit", ",", "were", "evident", "in", "all", "three", "cell", "lines"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414910", "name": "C1414910#ent", "pos": [4, 5]}}
{"token": ["Neither", "the", "individual", "SNPs", "in", "the", "studied", "C1417679#ent", "<e1>", "nor", "the", "haplotypes", "in", "the", "C1412854#ent", "<e2>", ",", "CENPE", "and", "TTK", "C1417679#ent", "<e1>", "caused", "any", "significant", "effect", "on", "the", "risk", "of", "BC", "."], "h": {"id": "C1412854", "name": "C1412854#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [7, 8]}}
{"token": ["Although", "aspirin", "and", "C0982192#ent", "<e1>", "cornerstones", "in", "the", "management", "of", "C0002965#ent", "<e2>", "non-Q-wave", "MI", ",", "both", "have", "significant", "limitations", "that", "have", "prompted", "the", "development", "of", "new", "agents", "."], "h": {"id": "C0982192", "name": "C0982192#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [10, 11]}}
{"token": ["C0394006#ent", "<e1>", "increases", "the", "risk", "of", "breast", "cancer", "women", "who", "took", "the", "C0013227#ent", "<e2>", "and", "the", "risk", "of", "reproductive", "tract", "abnormalities", "in", "their", "offspring", "."], "h": {"id": "C0394006", "name": "C0394006#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["We", "determined", "the", "platelet", "count", "MPV", "in", "100", "normal", "subjects", "in", "147", "subjects", "with", "thrombocytopenia", "or", "C3277671#ent", "<e1>", "due", "to", "other", "than", "C0018939#ent", "<e2>", "and", "in", "smaller", "groups", "with", "immune", "or", "septic", "thrombocytopenia", "iron", "deficiency"], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [22, 23]}}
{"token": ["All", "15", "C0042847#ent", "<e1>", "patients", "without", "anemia", "had", "normal", "C1366564#ent", "<e2>", "levels", ",", "including", "the", "4", "patients", "with", "macrocytosis", "and", "3", "in", "whom", "metabolic", "cobalamin", "deficiency", "the", "marrow", "cells", "documented", "with", "the", "deoxyuridine", "suppression", "test"], "h": {"id": "C0042847", "name": "C0042847#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366564", "name": "C1366564#ent", "pos": [9, 10]}}
{"token": ["The", "C0062941#ent", "<e1>", "represents", "haplotypes", "of", "both", "copies", "of", "C1334043#ent", "<e2>", "allowing", "for", "direct", "comparisons", "of", "the", "autosomes", "among", "multiple", "patients", "and", "enabling", "the", "identification", "of", "the", "shared", "segments", "."], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["C0003292#ent", "<e1>", "including", "loperamide", ",", "diphenoxylate", ",", "and", "C0012525#ent", "<e2>", ")", "and", "the", "tricyclic", "antidepressant", "amitriptyline", "improve", "continence", "in", "patients", "with", "diarrhea-associated", "incontinence"], "h": {"id": "C0003292", "name": "C0003292#ent", "pos": [0, 1]}, "relation": "therapeutic_class_of", "t": {"id": "C0012525", "name": "C0012525#ent", "pos": [8, 9]}}
{"token": ["Nonspecific", "C0003292#ent", "<e1>", "eg", ",", "loperamide", ",", "C0012525#ent", "<e2>", ")", "may", "be", "administered", ",", "but", "appear", "to", "be", "largely", "ineffective", "in", "this", "population", "."], "h": {"id": "C0003292", "name": "C0003292#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0012525", "name": "C0012525#ent", "pos": [7, 8]}}
{"token": ["C1420401#ent", "<e1>", "is", "present", "in", "C0669365#ent", "<e2>", "and", "smooth", "muscle", "cells", "as", "assessed", "by", "immunocytochemical", "and", "Western", "blot", "analyses"], "h": {"id": "C1420401", "name": "C1420401#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [5, 6]}}
{"token": ["The", "US", "found", "22", "with", "C1623038#ent", "<e1>", ",", "24", "with", "chronic", "liver", "disease", "133", "with", "C2711227#ent", "<e2>", "and", "14", "with", "a", "liver", "cyst"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "this", "review", "is", "to", "discuss", "recent", "findings", "regarding", "prevalence", ",", "risk", "factors", "outcome", "of", "severe", "C0024117#ent", "<e1>", "exacerbations", "caused", "by", "C0206526#ent", "<e2>"], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0206526", "name": "C0206526#ent", "pos": [23, 24]}}
{"token": ["Some", "of", "the", "identified", "C0017337#ent", "<e1>", ",", "such", "as", "C1417874#ent", "<e2>", ",", "interferon", "regulatory", "factor", "4", "and", "tissue", "inhibitor", "metalloproteinases", "1", "are", "already", "known", "to", "be", "associated", "with", "high-grade", "non-Hodgkin's", "lymphoma"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417874", "name": "C1417874#ent", "pos": [9, 10]}}
{"token": ["For", "the", "S5", ",", "S4S5", ",", "S5S5", ",", "and", "C1419736#ent", "<e1>", "phenotypes", ",", "the", "mean", "concentrations", "of", "serum", "C1439335#ent", "<e2>", "substantially", "higher", "among", "the", "APR", "patients", "."], "h": {"id": "C1419736", "name": "C1419736#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1439335", "name": "C1439335#ent", "pos": [18, 19]}}
{"token": ["MPTP", "was", "found", "to", "elicit", "not", "only", "the", "activation", "of", "the", "C1720985#ent", "<e1>", "also", "the", "initiators", "C1705065#ent", "<e2>", "and", "caspase-9", ",", "mitochondrial", "cytochrome", "c", ",", "and", "Bid", "cleavage", "the", "SN", "of", "wild-type", "mice"], "h": {"id": "C1720985", "name": "C1720985#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [16, 17]}}
{"token": ["The", "orofacial", "manifestations", "associated", "with", "autoimmune", "disorders", "oral", "mucosa", "alterations", ",", "salivary", "gland", "pathosis", "C0699739#ent", "<e1>", "headaches", ",", "and", "C0039494#ent", "<e2>"], "h": {"id": "C0699739", "name": "C0699739#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039494", "name": "C0039494#ent", "pos": [19, 20]}}
{"token": ["The", "results", "of", "the", "present", "study", "showed", "activation", "of", "C1413138#ent", "<e1>", "and", "glutathione-S-transferase", "after", "C3539739#ent", "<e2>", "and", "EE", "exposure", ",", "as", "well", "as", "increased", "emergence", "failure", "EE", "exposure", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539739", "name": "C3539739#ent", "pos": [14, 15]}}
{"token": ["All", "the", "C1562036#ent", "<e1>", "had", "inhibitory", "effects", "on", "ouabain-sensitive", "(", "Na+", "+", "K+)-ATPase", "C1417500#ent", "<e2>", "+", "-ATPase", "and", "Ca2", "+", "-ATPase", "activities", "in", "synaptosomes", "at", "high", "concentrations", "(", "10", "or", "100", "microM", ")", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [13, 14]}}
{"token": ["The", "expression", "of", "neuronal", "nitric", "oxide", "synthase", "nNOS", ")", ",", "C1623430#ent", "<e1>", ",", "and", "the", "low-affinity", "neurotrophin", "receptor", "C1420062#ent", "<e2>", ")", "following", "treatment", "with", "these", "neurotrophic", "factors", "also", "examined", "."], "h": {"id": "C1623430", "name": "C1623430#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420062", "name": "C1420062#ent", "pos": [18, 19]}}
{"token": ["Thus", ",", "C1540072#ent", "<e1>", "represents", "a", "new", "member", "of", "the", "C0085077#ent", "<e2>", "family", "of", "autoantigens", "and", "could", "become", "an", "additional", "and", "important", "diagnostic", "marker", "C0085077#ent", "<e2>", "and", "SLE", "."], "h": {"id": "C1540072", "name": "C1540072#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085077", "name": "C0085077#ent", "pos": [10, 11]}}
{"token": ["Consistent", "with", ",", "C0812385#ent", "<e1>", "stimulation", "induced", "rapid", "and", "transient", "translocation", "of", "the", "Src", "homology", "2", "C0259479#ent", "<e2>", "SHIP", ",", "into", "lipid", "rafts"], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0259479", "name": "C0259479#ent", "pos": [16, 17]}}
{"token": ["The", "expression", "pattern", "of", "C1415537#ent", "<e1>", "was", "similar", "to", "that", "of", "SMemb/NMHC-B", ",", "a", "nonmuscle", "C0597298#ent", "<e2>", "of", "myosin", "heavy", "chain", "we", "have", "previously", "reported", "to", "be", "a", "molecular", "marker", "dedifferentiated", "VSMCs", "."], "h": {"id": "C1415537", "name": "C1415537#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [15, 16]}}
{"token": ["Tamoxifen", "clearly", "reduced", "the", "C4284890#ent", "<e1>", "increase", "of", "apolipoprotein", "AI", "C1847987#ent", "<e2>", "total", "HDL", "cholesterol"], "h": {"id": "C4284890", "name": "C4284890#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1847987", "name": "C1847987#ent", "pos": [10, 11]}}
{"token": ["A", "phospholipase", "C", "inhibitor", "U-73122", ")", "and", "a", "protein", "kinase", "C", "PKC", ")", "inhibitor", "(", "C1420357#ent", "<e1>", ")", "inhibited", "57-kDa", "protein-stimulated", "he-patocyte", "DNA", "synthesis", "whereas", "a", "C1449702#ent", "<e2>", "H-89", ")", "did", "not", "."], "h": {"id": "C1420357", "name": "C1420357#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1449702", "name": "C1449702#ent", "pos": [26, 27]}}
{"token": ["C0017601#ent", "<e1>", "is", "a", "C0015397#ent", "<e2>", "leads", "to", "irreversible", "blindness", "."], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [4, 5]}}
{"token": ["Autopsy", "of", "a", "4-year-old", "girl", "with", "C0268490#ent", "<e1>", "a", "hepatocellular", "carcinoma", "addition", "to", "C0023890#ent", "<e2>", "and", "renal", "tubular", "dysplasia"], "h": {"id": "C0268490", "name": "C0268490#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [13, 14]}}
{"token": ["Haptoglobin-related", "protein", "HPR", ")", "is", "a", "serum", "protein", "is", ">", "90", "%", "C1512488#ent", "<e1>", "to", "the", "acute-phase", "reactant", "haptoglobin", "C1704665#ent", "<e2>", ")", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [19, 20]}}
{"token": ["Recently", "we", "found", "that", "Chit", "activity", "higher", "in", "patients", "affected", "by", "Plasmodium", "falciparum", "C0024530#ent", "<e1>", "infection", ",", "suggesting", "that", "C3889440#ent", "<e2>", "may", "reflect", "induction", "of", "an", "immunological", "response"], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3889440", "name": "C3889440#ent", "pos": [19, 20]}}
{"token": ["Outside", "the", "protein-coding", "region", "the", "C1436312#ent", "<e1>", "not", "share", "significant", "sequence", "similarity", "other", "class", "mu", "C0017837#ent", "<e2>"], "h": {"id": "C1436312", "name": "C1436312#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [15, 16]}}
{"token": ["Using", "information", "obtained", "from", "experiments", "with", "peptide", "substrates", "of", "C3853557#ent", "<e1>", ",", "a", "motif", "within", "the", "cGMP-binding", "domain", "cGMP-dependent", "protein", "kinase", "C4084713#ent", "<e2>", ")", "was", "identified", "as", "a", "potential", "phosphorylation", "site", "for", "C3853557#ent", "<e1>", "."], "h": {"id": "C4084713", "name": "C4084713#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3853557", "name": "C3853557#ent", "pos": [9, 10]}}
{"token": ["C3539620#ent", "<e1>", "activation", "is", "required", "for", "the", "phosphorylation", "of", "C0600388#ent", "<e2>", "2", "by", "NGF", "that", "is", "necessary", "for", "neurite", "growth"], "h": {"id": "C3539620", "name": "C3539620#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0600388", "name": "C0600388#ent", "pos": [9, 10]}}
{"token": ["An", "epidemiological", "study", "conducted", "in", "France", "to", "estimate", "the", "prevalence", "of", "C0162309#ent", "<e1>", ",", "a", "severe", "C1848144#ent", "<e2>", "boys", "and", "young", "men", "."], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1848144", "name": "C1848144#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "C2699120#ent", "<e1>", "behaves", "as", "a", "C1413078#ent", "<e2>", "could", "act", "as", "a", "basic", "peptide", "peptidase", "a", "somewhat", "regulatory", "protein", "other", "protein", "activities", "rickettsiae", "."], "h": {"id": "C2699120", "name": "C2699120#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413078", "name": "C1413078#ent", "pos": [7, 8]}}
{"token": ["In", "the", "current", "study", ",", "yeast", "two-hybrid", "analysis", "used", "to", "demonstrate", "that", "C1332708#ent", "<e1>", "interacts", "with", "AP50", ",", "the", "medium", "chain", "subunit", "the", "C0919496#ent", "<e2>", "complex", ",", "via", "tyrosine-based", "internalization", "motifs", "in", "its", "cytoplasmic", "domain"], "h": {"id": "C1332708", "name": "C1332708#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0919496", "name": "C0919496#ent", "pos": [23, 24]}}
{"token": ["Those", "findings", "suggest", "that", "C1417771#ent", "<e1>", "might", "indirectly", "influence", "disease", "progression", "C0027726#ent", "<e2>"], "h": {"id": "C1417771", "name": "C1417771#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [11, 12]}}
{"token": ["C0908935#ent", "<e1>", "and", "norastemizole", ",", "metabolites", "of", "loratadine", "and", "C0085170#ent", "<e2>", ",", "respectively", ",", "are", "2", "other", "second", "generation", "antihistamines", "found", "to", "be", "effective", "treatments", "for", "seasonal", "allergic", "rhinitis"], "h": {"id": "C0908935", "name": "C0908935#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085170", "name": "C0085170#ent", "pos": [9, 10]}}
{"token": ["C0010762#ent", "<e1>", ")", "is", "the", "isozyme", "most", "closely", "associated", "with", "aryl", "hydrocarbon", "hydroxylase", "C1705794#ent", "<e2>", ")", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705794", "name": "C1705794#ent", "pos": [13, 14]}}
{"token": ["Neither", "PMSG", "nor", "oestradiol", "benzoate", "stimulated", "C0010762#ent", "<e1>", "levels", "or", "C1705794#ent", "<e2>", "activity", "in", "hypophysectomized", "rats.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705794", "name": "C1705794#ent", "pos": [10, 11]}}
{"token": ["Both", "macrophage", "lysosomal", "lysate", "and", "commercial", "C0062507#ent", "<e1>", "at", "neutral", "pH", "induced", "smooth", "muscle", "phenotypic", "change", "while", "other", "C3540772#ent", "<e2>", "such", "as", "trypsin", "and", "chondroitin", "ABC", "lyase", "no", "effect"], "h": {"id": "C0062507", "name": "C0062507#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [18, 19]}}
{"token": ["This", "protein", "act", "as", "a", "C0027021#ent", "<e1>", "linked", "to", "thioredoxin", "(Trx)/thioredoxin", "reductase", "C1705610#ent", "<e2>", ")", "."], "h": {"id": "C0027021", "name": "C0027021#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705610", "name": "C1705610#ent", "pos": [12, 13]}}
{"token": ["Clinical", "studies", "heart", "failure", "losartan", ",", "an", "C0521942#ent", "<e1>", "found", "that", "this", "C1254351#ent", "<e2>", "is", "well", "tolerated", "and", "demonstrates", "hemodynamic", ",", "neurohormonal", ",", "and", "symptomatic", "improvement", "."], "h": {"id": "C0521942", "name": "C0521942#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["An", "antagonist", "of", "platelet-activating", "factor", "PAF", ")", ",", "WEB", "2086", "completely", "inhibited", "the", "platelet", "adhesion", "induced", "by", "C1705725#ent", "<e1>", ",", "while", "indomethacin", "and", "C0050341#ent", "<e2>", "had", "no", "effect"], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0050341", "name": "C0050341#ent", "pos": [23, 24]}}
{"token": ["Our", "findings", "reveal", "that", "the", "C0214604#ent", "<e1>", "regulate", "the", "C0282625#ent", "<e2>", "a", "non-enzymatic", "mechanism", "."], "h": {"id": "C0214604", "name": "C0214604#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0282625", "name": "C0282625#ent", "pos": [9, 10]}}
{"token": ["Given", "the", "severity", "of", "the", "ocular", "and", "systemic", "complications", "of", "C0009763#ent", "<e1>", "clinicians", "are", "reminded", "that", "prompt", "detection", "and", "treatment", "of", "C0149866#ent", "<e2>", "critical", "."], "h": {"id": "C0009763", "name": "C0009763#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C0149866", "name": "C0149866#ent", "pos": [21, 22]}}
{"token": ["Inhibition", "of", "the", "STA2-induced", "aggregation", "by", "C0133967#ent", "<e1>", "may", "be", "associated", "with", "cAMP-dependent", "protein", "phosphorylation", "while", "C0055728#ent", "<e2>", "may", "have", "inhibitory", "effects", "on", "STA2-induced", "platelet", "activation", "mechanisms", "other", "than", "the", "activation", "of", "A", "kinase", "."], "h": {"id": "C0133967", "name": "C0133967#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0055728", "name": "C0055728#ent", "pos": [16, 17]}}
{"token": ["Gene", "mapping", "that", "the", "dwarf", "mutation", "closely", "linked", "to", "the", "thyroid", "peroxidase", "C1364508#ent", "<e1>", ")", "gene", "on", "C0795843#ent", "<e2>"], "h": {"id": "C1364508", "name": "C1364508#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0795843", "name": "C0795843#ent", "pos": [17, 18]}}
{"token": ["The", "role", "of", "ERK", ",", "Ras", "and", "C0033634#ent", "<e1>", "were", "investigated", "using", "specific", "inhibitors", ",", "PD", "98059", ",", "C0065712#ent", "<e2>", "calphostin", "C", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0065712", "name": "C0065712#ent", "pos": [18, 19]}}
{"token": ["Gerstmann-Str\u00e4ussler-Scheinker", "(", "C0017495#ent", "<e1>", ")", "disease", "is", "a", "C0027765#ent", "<e2>", "pathologically", "characterized", "by", "accumulation", "of", "prion", "protein", "PrP", ")", "in", "the", "form", "of", "fibrillary", "and", "non-fibrillary", "deposits", "within", "the", "cerebrum", "and", "cerebellum", "."], "h": {"id": "C0017495", "name": "C0017495#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [8, 9]}}
{"token": ["Omeprazole", "also", "provided", "significantly", "greater", "relief", "from", "C0018834#ent", "<e1>", "nighttime", "heartburn", "and", "acid", "regurgitation", "and", "was", "associated", "with", "decreased", "concomitant", "C0003216#ent", "<e2>", "use", "."], "h": {"id": "C0018834", "name": "C0018834#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003216", "name": "C0003216#ent", "pos": [20, 21]}}
{"token": ["However", ",", "this", "diet", "affects", "neither", "nucleotides", "(", "inosine", "monophosphate", "adenosine", "monophosphate", "adenosine", "diphosphate", "adenosine", "triphosphate", "in", "red", "blood", "cells", "enzymes", "(", "C0034135#ent", "<e1>", "adenosine", "deaminase", "hypoxanthine", "guanine", "phosphoribosyl", "transferase", "in", "red", "blood", "cells", "the", "fractional", "clearance", "of", "C0030086#ent", "<e2>", "."], "h": {"id": "C0034135", "name": "C0034135#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0030086", "name": "C0030086#ent", "pos": [38, 39]}}
{"token": ["C1706041#ent", "<e1>", "is", "encoded", "by", "one", "or", "several", "closely", "related", "C1417679#ent", "<e2>", "found", "at", "a", "single", "locus", ",", "position", "99A", "on", "the", "right", "arm", "of", "chromosome", "3"], "h": {"id": "C1706041", "name": "C1706041#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["The", "intralobular", "distribution", "of", "activity", "of", "glycogen", "phosphorylase", "C1705010#ent", "<e1>", ")", ",", "a", "key", "C0014442#ent", "<e2>", "in", "the", "breakdown", "of", "glycogen", ",", "was", "evaluated", "to", "determine", "changes", "during", "early", "glycogen", "synthesis"], "h": {"id": "C1705010", "name": "C1705010#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}}
{"token": ["C0597094#ent", "<e1>", "potentially", "required", "for", "resistance", "of", "the", "C1819716#ent", "<e2>", "such", "agents", "."], "h": {"id": "C0597094", "name": "C0597094#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1819716", "name": "C1819716#ent", "pos": [8, 9]}}
{"token": ["However", ",", "we", "did", "find", "that", "mutants", "with", "disruptions", "in", "the", "ubc1", "gene", ",", "which", "encodes", "the", "regulatory", "subunit", "C0010531#ent", "<e1>", ",", "were", "resistant", "to", "both", "C0078245#ent", "<e2>", "and", "chloroneb", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0078245", "name": "C0078245#ent", "pos": [26, 27]}}
{"token": ["These", "data", "indicate", "that", "C1417739#ent", "<e1>", "abnormal", "in", "the", "course", "of", "C1419789#ent", "<e2>", "and", "that", "it", "could", "be", "modified", "by", "different", "proportions", "of", "both", "inhibitors", "and", "stimulators", "of", "chemotaxis", "."], "h": {"id": "C1417739", "name": "C1417739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419789", "name": "C1419789#ent", "pos": [11, 12]}}
{"token": ["and", "that", "both", "the", "increased", "C0962754#ent", "<e1>", "and", "CIF", "activities", "are", "reflections", "of", "collagen", "C0221406#ent", "<e2>", "in", "CML", "."], "h": {"id": "C0962754", "name": "C0962754#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [14, 15]}}
{"token": ["Temporary", "responses", "were", "noted", "after", "combination", "chemotherapy", "with", "vincristine", ",", "actinomycin", "D", "and", "C0010583#ent", "<e1>", "or", "with", "C1170010#ent", "<e2>", "and", "etoposide", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1170010", "name": "C1170010#ent", "pos": [17, 18]}}
{"token": ["The", "gastroprotective", "properties", "of", "C4289847#ent", "<e1>", ",", "an", "indigenous", "component", "of", "C0812384#ent", "<e2>", "was", "investigated", "."], "h": {"id": "C4289847", "name": "C4289847#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812384", "name": "C0812384#ent", "pos": [11, 12]}}
{"token": ["Botulinum", "toxin", "therapy", "be", "considered", "for", "both", "temporary", "and", "permanent", "facial", "asymmetries", "to", "C0015469#ent", "<e1>", "well", "as", "C0026821#ent", "<e2>", "."], "h": {"id": "C0015469", "name": "C0015469#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0026821", "name": "C0026821#ent", "pos": [17, 18]}}
{"token": ["The", "critical", "period", "of", "C1337091#ent", "<e1>", "probably", "short", "and", "the", "process", "leading", "to", "C0011849#ent", "<e2>", "probably", "has", "a", "long", "prodrome", "but", "of", "variable", "duration", "that", "determines", "the", "age", "at", "presentation", "with", "clinical", "disease"], "h": {"id": "C1337091", "name": "C1337091#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [13, 14]}}
{"token": ["Experiments", "performed", "in", "vivo", "hypophysectomized", "female", "rats", "indicate", "that", "the", "C0041236#ent", "<e1>", "digest", "of", "16k", "fragment", "stimulates", "cholesterol", "ester", "hydrolase", "cholesterol", "esterase", "C0008385#ent", "<e2>", "EC", "3.1.1.13)", "activity", "in", "the", "adrenal", "cortex", "fails", "to", "activate", "cholesterol", "side-chain", "cleavage"], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [22, 23]}}
{"token": ["C0041236#ent", "<e1>", "pretreatment", "was", "not", "required", "for", "C0008385#ent", "<e2>", "hydrolysis", "of", "LDL", "oxidized", "with", "copper", ",", "a", "treatment", "that", "also", "degrades", "apolipoprotein", "B", "the", "major", "protein", "moiety", "LDL", "."], "h": {"id": "C0041236", "name": "C0041236#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [7, 8]}}
{"token": ["To", "study", "how", "mitochondria", "dynamics", "affects", "cell", "Ca2", "homeostasis", ",", "we", "C3889446#ent", "<e1>", "two", "mitochondrial", "fission", "proteins", "hFis1", "and", "C1413979#ent", "<e2>", ",", "and", "measured", "Ca2", "+", "changes", "within", "the", "cytosol", "and", "the", "ER", "in", "HeLa", "cells"], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413979", "name": "C1413979#ent", "pos": [19, 20]}}
{"token": ["No", "relationship", "was", "found", "between", "C0242209#ent", "<e1>", "consumption", ",", "plasma", "zinc", ",", "and", "taste", "acuity", "in", "C0010346#ent", "<e2>"], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [16, 17]}}
{"token": ["Interacting", "proteins", "included", "amylase", ",", "C1424869#ent", "<e1>", "basic", "proline-rich", "protein", "3", "lacrimal", "proline-rich", "protein", "4", "statherin", "and", "C1415800#ent", "<e2>"], "h": {"id": "C1424869", "name": "C1424869#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1415800", "name": "C1415800#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "the", "concentration", "of", "the", "two", "soluble", "C1363984#ent", "<e1>", "sTNFR", ")", ",", "sp55", "and", "C1420337#ent", "<e2>", ",", "in", "healthy", "pregnant", "."], "h": {"id": "C1363984", "name": "C1363984#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420337", "name": "C1420337#ent", "pos": [15, 16]}}
{"token": ["The", "sequence", "thus", "includes", "the", "C0017337#ent", "<e1>", ",", "N", ",", "ral", ",", "C1416971#ent", "<e2>", ",", "cIII", ",", "kil", "and", "gam", ",", "as", "well", "as", "the", "transcription", "terminators", "TL1", "TL2", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416971", "name": "C1416971#ent", "pos": [12, 13]}}
{"token": ["C0008783#ent", "<e1>", "inhibited", "meperidine", "and", "C0030883#ent", "<e2>", "both", "rat", "and", "human", "hepatic", "microsomes", "ranitidine", "did", "not", "affect", "these", "two", "cytochrome", "P450-medicated", "biotransformation", "reactions", "."], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [5, 6]}}
{"token": ["Our", "results", "indicate", "that", "cyclosporin", "administered", "by", "the", "central", "route", "as", "effective", "as", "by", "the", "systemic", "route", "to", "reduce", "C0020429#ent", "<e1>", "hindpaw", "edema", "in", "C0035012#ent", "<e2>", "rats", "."], "h": {"id": "C0020429", "name": "C0020429#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0035012", "name": "C0035012#ent", "pos": [24, 25]}}
{"token": ["The", "effects", "of", "calcium", "antagonists", "C0012373#ent", "<e1>", "and", "nicardipine", "on", "portal", "pressure", "C4022560#ent", "<e2>", "studied", "in", "awake", ",", "unrestrained", "portal", "hypertensive", "rats", "."], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4022560", "name": "C4022560#ent", "pos": [12, 13]}}
{"token": ["The", "study", "also", "showed", "that", "the", "activated", "C3540546#ent", "<e1>", "augmented", "the", "SAL-triggered", "C1336605#ent", "<e2>", "disruption", ",", "whereas", "C1336605#ent", "<e2>", "reduction", "in", "turn", "enhanced", "C3540546#ent", "<e1>", "function", "."], "h": {"id": "C3540546", "name": "C3540546#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1336605", "name": "C1336605#ent", "pos": [12, 13]}}
{"token": ["This", "study", "demonstrates", "that", "continuous", "TPA", "treatment", ",", "although", "initially", "down-regulating", "the", "protein", "kinase", "effect", "of", "carbachol", "on", "C1537503#ent", "<e1>", "redistribution", ",", "uncouples", "carbachol", "and", "C0033634#ent", "<e2>", "longer", "times", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0033634", "name": "C0033634#ent", "pos": [25, 26]}}
{"token": ["Dopamine-deficient", "DAT-KO", "mice", "(", "DDD", "mice", ")", "demonstrate", "a", "striking", "behavioral", "phenotype", "manifested", "as", "severe", "C1276035#ent", "<e1>", ",", "rigidity", ",", "tremor", ",", "and", "C0005745#ent", "<e2>", "."], "h": {"id": "C1276035", "name": "C1276035#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [23, 24]}}
{"token": ["Subcutaneous", "injections", "apomorphine", "in", "bilaterally", "lesioned", "rats", "abolished", "C1276035#ent", "<e1>", "and", "catalepsy", "while", "rigidity", "and", "C0005745#ent", "<e2>", "were", "unaffected", "."], "h": {"id": "C1276035", "name": "C1276035#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0005745", "name": "C0005745#ent", "pos": [15, 16]}}
{"token": ["This", "disorder", "can", "result", "either", "from", "deficient", "secretion", "of", "vasopressin", "(", "C0011848#ent", "<e1>", ",", "or", "from", "renal", "resistance", "vasopressin", "(", "C0162283#ent", "<e2>", ",", "primary", "polydipsia", "osmotic", "diuresis", "electrolytic", "disorders", "drugs", "."], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0162283", "name": "C0162283#ent", "pos": [20, 21]}}
{"token": ["The", "inhibitory", "effect", "of", "ANP", "on", "C0039902#ent", "<e1>", "mRNA", "level", "was", "reverted", "in", "the", "presence", "of", "C0043167#ent", "<e2>", "an", "inhibitor", "of", "the", "G(i)-protein-mediated", "reduction", "of", "the", "adenylate", "cyclase", "activity", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [16, 17]}}
{"token": ["The", "C1420369#ent", "<e1>", "FDP", "(", "fibrinogen", "degradation", "products", ",", "and", "C1842690#ent", "<e2>", "(", "N-acetyl-beta-D-glucosaminidase", ")", "in", "renal", "transplanted", "patients", "were", "studied", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1842690", "name": "C1842690#ent", "pos": [10, 11]}}
{"token": ["C1095795#ent", "<e1>", "is", "among", "the", "most", "popular", "C0013231#ent", "<e2>", "Europe", "and", "is", "also", "available", "in", "the", "United", "States", "primarily", "in", "health", "food", "stores", "."], "h": {"id": "C1095795", "name": "C1095795#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013231", "name": "C0013231#ent", "pos": [7, 8]}}
{"token": ["After", "transfection", "of", "INS-1E", "cells", "with", "C0001486#ent", "<e1>", "containing", "the", "CSE", "gene", "Ad-CSE", ")", "to", "overexpress", "C2984132#ent", "<e2>", ",", "high", "glucose-stimulated", "insulin", "secretion", "was", "virtually", "abolished", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2984132", "name": "C2984132#ent", "pos": [16, 17]}}
{"token": ["Our", "objectives", "were", "to", "describe", "the", "presentation", "and", "course", "of", "hyperemesis", "gravidarum", "respect", "to", "thyroid", "function", "to", "test", "the", "hypothesis", "that", "patients", "with", "C0020550#ent", "<e1>", "in", "clinical", "presentation", "euthyroid", "C0235250#ent", "<e2>", "patients", "."], "h": {"id": "C0020550", "name": "C0020550#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0235250", "name": "C0235250#ent", "pos": [29, 30]}}
{"token": ["Analysis", "by", "1H", "NMR", "spectroscopy", "hydrolysis", "of", "C0769628#ent", "<e1>", "showed", "that", "the", "C0027203#ent", "<e2>", "acts", "by", "the", "retaining", "mechanism", "."], "h": {"id": "C0769628", "name": "C0769628#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [12, 13]}}
{"token": ["Neither", "the", "C3536910#ent", "<e1>", "indomethacin", "nor", "the", "C0304512#ent", "<e2>", "propranolol", "influenced", "levosimendan-induced", "vasorelaxation", "."], "h": {"id": "C3536910", "name": "C3536910#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0304512", "name": "C0304512#ent", "pos": [7, 8]}}
{"token": ["Medical", "management", "C0429468#ent", "<e1>", "dysfunctional", "uterine", "bleeding", "may", "include", "oral", "C0009905#ent", "<e2>", "cyclic", "progestins"], "h": {"id": "C0429468", "name": "C0429468#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0009905", "name": "C0009905#ent", "pos": [10, 11]}}
{"token": ["ER", "alpha", "activation", "of", "C1333711#ent", "<e1>", "is", "dependent", "on", "C1332669#ent", "<e2>", ",", "whereas", "CAV3", "is", "necessary", "for", "ER", "alpha", "ER", "beta", "of", "mGluR2/3", "."], "h": {"id": "C1333711", "name": "C1333711#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332669", "name": "C1332669#ent", "pos": [9, 10]}}
{"token": ["Newer", "pharmacological", "approaches", "butyrophenones", ",", "cannabinoids", ",", "metoclopramide", ",", "high-dose", "corticosteroids", "and", "C4048284#ent", "<e1>", "have", "shown", "increased", "C3536993#ent", "<e2>", "efficacy", ",", "as", "have", "combinations", "of", "these", "agents", "which", "are", "directed", "against", "multiple", "sites", "emetogenic", "activity"], "h": {"id": "C4048284", "name": "C4048284#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3536993", "name": "C3536993#ent", "pos": [17, 18]}}
{"token": ["The", "MSH", "release-inhibiting", "effect", "of", "C0062961#ent", "<e1>", "and", "isoguvacine", "could", "be", "antagonized", "by", "the", "specific", "C2936801#ent", "<e2>", "bicuculline", "."], "h": {"id": "C0062961", "name": "C0062961#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936801", "name": "C2936801#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "all", "C0030956#ent", "<e1>", "derived", "from", "pro-enkephalin", "A", "full", "agonistic", "activity", "BAM-22P", "and", "C0070342#ent", "<e2>", "the", "most", "potent", "C0030956#ent", "<e1>", "."], "h": {"id": "C0070342", "name": "C0070342#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [4, 5]}}
{"token": ["Immunohistochemistry", "and", "ligand-binding", "studies", "here", "demonstrate", ",", "however", ",", "that", "C5aR", "is", "expressed", "by", "parenchymal", "cells", "several", "solid", "organs", "including", "human", "C0023899#ent", "<e1>", "hepatocytes", ",", "lung", "bronchial", "alveolar", "epithelial", "cells", "and", "C1412137#ent", "<e2>", "endothelial", "cells"], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [31, 32]}}
{"token": ["Since", "alkylsulfonates", "are", "C3810625#ent", "<e1>", "substrates", ",", "it", "suggests", "that", "the", "C0015625#ent", "<e2>", "binding", "site", "located", "in", "the", "anion", "channel"], "h": {"id": "C3810625", "name": "C3810625#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [11, 12]}}
{"token": ["C0055729#ent", "<e1>", "was", "perorally", "administered", "at", "day", "1", "after", "having", "confirmed", "significant", "C3252090#ent", "<e2>", "using", "BB-MRI", "."], "h": {"id": "C0055729", "name": "C0055729#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3252090", "name": "C3252090#ent", "pos": [12, 13]}}
{"token": ["Damage", "to", "the", "basal", "ganglia", "cerebellar", "components", "circuits", "with", "motor", "areas", "C0001614#ent", "<e1>", "leads", "to", "C1457887#ent", "<e2>", "whereas", "damage", "of", "the", "subcortical", "components", "of", "circuits", "with", "non-motor", "areas", "of", "C0001614#ent", "<e1>", "causes", "higher-order", "deficits", "."], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [15, 16]}}
{"token": ["The", "metalloproteinase", "inhibitor", "1", "10-phenanthroline", "inhibited", "the", "cleavage", "of", "the", "extracellular", "domain", "C1413277#ent", "<e1>", "and", "concomitantly", "inhibited", "the", "serum-deprivation-induced", "apoptosis", "of", "aggregated", "C1522376#ent", "<e2>", "."], "h": {"id": "C1413277", "name": "C1413277#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1522376", "name": "C1522376#ent", "pos": [22, 23]}}
{"token": ["C0017923#ent", "<e1>", "GSD-IV", ";", "Andersen", "disease", "is", "an", "autosomal", "recessive", "disorder", "by", "C0023890#ent", "<e2>", "leading", "to", "severe", "liver", "failure"], "h": {"id": "C0017923", "name": "C0017923#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "the", "primary", "pharmacodynamic", "alteration", "in", "patients", "with", "C0018801#ent", "<e1>", "with", "healthy", "subjects", "less", "total", "sodium", "excretion", "per", "molecule", "of", "C0076840#ent", "<e2>", "reaching", "the", "renal", "tubule"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0076840", "name": "C0076840#ent", "pos": [21, 22]}}
{"token": ["AMP-activated", "protein", "kinase", "C2350345#ent", "<e1>", ")", "is", "an", "C0014442#ent", "<e2>", "that", "works", "as", "a", "fuel", "gauge", "being", "activated", "in", "situations", "of", "high-energy", "phosphate", "depletion", "."], "h": {"id": "C2350345", "name": "C2350345#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}}
{"token": ["4.8->7.2", "log", "of", "all", "the", "viruses", "tested", ",", "i.e.", "Sindbis", ",", "HSV-1", ",", "vaccinia", ",", "polio-1", ",", "EMC", ",", "C0019159#ent", "<e1>", ",", "CPV", ",", "BPV", "and", "C1456377#ent", "<e2>", "."], "h": {"id": "C0019159", "name": "C0019159#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1456377", "name": "C1456377#ent", "pos": [26, 27]}}
{"token": ["C0031727#ent", "<e1>", "henceforth", "be", "referred", "to", "as", "C2003410#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C2003410", "name": "C2003410#ent", "pos": [7, 8]}}
{"token": ["Reverse", "transcription", "polymerase", "chain", "reaction", "performed", "with", "primers", "specific", "for", "C3538973#ent", "<e1>", "AID", ")", "and", "for", "C4284744#ent", "<e2>", "IgG4", "."], "h": {"id": "C3538973", "name": "C3538973#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4284744", "name": "C4284744#ent", "pos": [16, 17]}}
{"token": ["C4255970#ent", "<e1>", "is", "an", "C3850168#ent", "<e2>", "is", "used", "for", "the", "treatment", "of", "breast", "cancer"], "h": {"id": "C4255970", "name": "C4255970#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3850168", "name": "C3850168#ent", "pos": [4, 5]}}
{"token": ["Two", "cases", "of", "acute", "carpal", "tunnel", "syndrome", "to", "median", "C0000833#ent", "<e1>", "a", "consequence", "of", "C0023343#ent", "<e2>", "reported", "."], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023343", "name": "C0023343#ent", "pos": [14, 15]}}
{"token": ["However", ",", "C1705325#ent", "<e1>", "not", "account", "for", "the", "Src-independent", "pathway", ",", "since", "simultaneous", "inhibition", "of", "both", "C1705325#ent", "<e1>", "Src", "did", "not", "completely", "block", "effects", "C1706604#ent", "<e1>", "on", "FAK", "phosphorylation", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706604", "name": "C1706604#ent", "pos": [24, 25]}}
{"token": ["C0006945#ent", "<e1>", ",", "a", "non-specific", "cholinergic", "C2987634#ent", "<e2>", ",", "selectively", "induced", "phosphorylation", "of", "TH", "at", "serine", "31", "in", "darkness", ",", "an", "effect", "which", "was", "blocked", "by", "the", "nicotinic", "antagonist", "d-tubocurarine", "."], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [6, 7]}}
{"token": ["Xorc2", "(", "C2984561#ent", "<e1>", ")", "is", "specifically", "associated", "with", "Xorc1", "(", "C1864009#ent", "<e2>", ")", "and", "up", "to", "four", "additional", "polypeptides", "(", "p81", ",", "p78", ",", "p45", ",", "and", "p40", ")", "."], "h": {"id": "C2984561", "name": "C2984561#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1864009", "name": "C1864009#ent", "pos": [11, 12]}}
{"token": ["Although", "no", "antigenic", "component", "the", "C0744421#ent", "<e1>", "detected", ",", "this", "C0156221#ent", "<e2>", "and", "arteritis", "may", "be", "diagnosed", "morphologically", "as", "an", "immune", "complex", "disease"], "h": {"id": "C0744421", "name": "C0744421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [10, 11]}}
{"token": ["The", "presentation", "of", "metastatic", "disease", "the", "hand", "in", "an", "occult", "malignancy", "be", "deceptive", ",", "often", "mimicking", "pulp", "space", "infection", ",", "C0029443#ent", "<e1>", ",", "septic", "arthritis", "gout", ",", "acute", "rheumatoid", "monoarticular", "arthritis", "tenosynovitis", ",", "or", "C0034931#ent", "<e2>"], "h": {"id": "C0029443", "name": "C0029443#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0034931", "name": "C0034931#ent", "pos": [34, 35]}}
{"token": ["Beta-thalassemia", "(", "beta-thal", ")", "is", "a", "C0019247#ent", "<e1>", "decreased", "or", "absent", "C1415481#ent", "<e2>"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415481", "name": "C1415481#ent", "pos": [11, 12]}}
{"token": ["To", "facilitate", "a", "better", "understanding", "of", "the", "regulation", "of", "aldA", ",", "the", "C0017337#ent", "<e1>", "encoding", "C0684287#ent", "<e2>", "AldDH", ")", "in", "the", "ascomycete", "fungus", "Aspergillus", "niger", "the", "C0017337#ent", "<e1>", "has", "been", "physically", "characterized", "."], "h": {"id": "C0684287", "name": "C0684287#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["C0072497#ent", "<e1>", "competed", "with", "heme", "for", "the", "C0014442#ent", "<e2>", ",", "suggesting", "that", "the", "native", "C0014442#ent", "<e2>", "is", "a", "hemoprotein", "."], "h": {"id": "C0072497", "name": "C0072497#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["The", "PKC", "inhibitor", "C0054537#ent", "<e1>", "decreased", "IL-6", "responses", "to", "C1705340#ent", "<e2>", "."], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [9, 10]}}
{"token": ["Our", "aims", "were", "to", "quantify", "and", "compare", "hepatic", "expression", "eNOS", ",", "C1426772#ent", "<e1>", ",", "NOSIP", ",", "and", "caveolin-1", "in", "alcoholic", "cirrhosis", "or", "without", "C0001306#ent", "<e2>", "in", "normal", "livers", "."], "h": {"id": "C1426772", "name": "C1426772#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001306", "name": "C0001306#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "cSrc", "and", "C0812303#ent", "<e1>", "siRNA", "significantly", "suppressed", "S1P-induced", "C1706508#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C0812303", "name": "C0812303#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706508", "name": "C1706508#ent", "pos": [10, 11]}}
{"token": ["This", "differential", "effect", "BFA", "was", "not", "caused", "by", "differences", "in", "the", "palmitoylation", "kinetics", "between", "wild-type", "C1706271#ent", "<e1>", "and", "the", "mutants", "and", "was", "not", "mimicked", "by", "C0028247#ent", "<e2>", "and", "monensin", "."], "h": {"id": "C1706271", "name": "C1706271#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0028247", "name": "C0028247#ent", "pos": [25, 26]}}
{"token": ["Among", "the", "possible", "renal", "complications", "can", "develop", "a", "human", "immunodeficiency", "virus-", "C0019693#ent", "<e1>", ")", "infected", "patient", ",", "C2717961#ent", "<e2>", "TMA", ")", "is", "one", "of", "them", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [17, 18]}}
{"token": ["C1418520#ent", "<e1>", "peptide", "had", "a", "protective", "effect", "C0242350#ent", "<e2>", "the", "rat", "mesenteric", "lymph", "vessels", "conditions", "of", "inflammation", ",", "irrespective", "of", "the", "time", "of", "its", "injection", "(", "before", "or", "after", "inflammatory", "agent", "."], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242350", "name": "C0242350#ent", "pos": [7, 8]}}
{"token": ["It", "is", "also", "concluded", "that", "C1424448#ent", "<e1>", "is", "not", "caused", "by", "the", "C1259236#ent", "<e2>", "germline", "variants", "R117", "G", ",", "R137Q", ",", "R145W", ",", "I157", "T", ",", "and", "R180H", "in", "familial", "colorectal", "cancer"], "h": {"id": "C1424448", "name": "C1424448#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1259236", "name": "C1259236#ent", "pos": [12, 13]}}
{"token": ["There", "are", "conflicting", "reports", "of", "an", "increase", "in", "the", "activity", "of", "C0010289#ent", "<e1>", "CK-BB", ")", "in", "the", "serum", "of", "patients", "with", "C0007820#ent", "<e2>"], "h": {"id": "C0010289", "name": "C0010289#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [21, 22]}}
{"token": ["The", "C0005064#ent", "<e1>", "diazepam", "and", "C0072828#ent", "<e2>", "produced", "behavioral", "and", "EEG", "effects", "which", "were", "completely", "antagonized", "by", "FG", "7142", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [1, 2]}, "relation": "chemical_structure_of", "t": {"id": "C0072828", "name": "C0072828#ent", "pos": [5, 6]}}
{"token": ["When", "C0076651#ent", "<e1>", "was", "added", "to", "the", "incubation", "medium", "N-demethylation", "rate", "of", "C0009214#ent", "<e2>", "and", "the", "hydroxylation", "of", "testosterone", "at", "the", "6", "beta-", "and", "11", "alpha-positions", "was", "strongly", "inhibited", "."], "h": {"id": "C0076651", "name": "C0076651#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0009214", "name": "C0009214#ent", "pos": [12, 13]}}
{"token": ["These", "data", "indicate", "that", "C1417085#ent", "<e1>", "is", "a", "novel", "C1336778#ent", "<e2>", "expressed", "in", "osteoblasts", "and", "that", "its", "level", "is", "under", "the", "control", "of", "1,25-dihydroxyvitamin", "D(3", ")", "."], "h": {"id": "C1417085", "name": "C1417085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1336778", "name": "C1336778#ent", "pos": [9, 10]}}
{"token": ["Induction", "of", "heat", "shock", "proteins", "C3890018#ent", "<e1>", ")", "or", "inhibition", "of", "C1417760#ent", "<e2>", "expression", "improves", "survival", "in", "LPS-challenged", "rodents", "."], "h": {"id": "C3890018", "name": "C3890018#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [11, 12]}}
{"token": ["C0175694#ent", "<e1>", "SLOS", ")", "is", "an", "autosomal", "recessive", "syndrome", "characterized", "by", "severe", "C0015544#ent", "<e2>", "congenital", "anomalies", "for", "example", "dysgenesis", ",", "mental", "retardation", "renal", "and", "cardiac", "defects", "and", "various", "malformation", ")", "."], "h": {"id": "C0175694", "name": "C0175694#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0015544", "name": "C0015544#ent", "pos": [12, 13]}}
{"token": ["We", "report", "a", "68-year-old", "man", "who", "developed", "C0042514#ent", "<e1>", "induced", "by", "combined", "use", "of", "mosapride", "and", "C0086303#ent", "<e2>", "."], "h": {"id": "C0042514", "name": "C0042514#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0086303", "name": "C0086303#ent", "pos": [16, 17]}}
{"token": ["The", "level", "of", "C0015683#ent", "<e1>", "mRNA", "varied", "in", "parallel", "with", "SREBP-1c", ",", "while", "C1417019#ent", "<e2>", "mRNA", "was", "unaffected", "."], "h": {"id": "C0015683", "name": "C0015683#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417019", "name": "C1417019#ent", "pos": [13, 14]}}
{"token": ["No", "significant", "between", "the", "effects", "of", "Pirenzepine", "and", "C0027235#ent", "<e1>", "on", "histamine", "induced", "C0006266#ent", "<e2>", "were", "observed", "."], "h": {"id": "C0027235", "name": "C0027235#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [13, 14]}}
{"token": ["The", "selectivity", "decreased", "in", "the", "following", "order", ":", "CCM", "(", "inverse", "agonist", ")", ",", "C0060309#ent", "<e1>", "partial", "inverse", "agonist", ")", ",", "ZK", "93426", "antagonist", ")", "and", "C0078826#ent", "<e2>", "agonist", ")", "."], "h": {"id": "C0060309", "name": "C0060309#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0078826", "name": "C0078826#ent", "pos": [26, 27]}}
{"token": ["Here", ",", "we", "show", "that", "C1335624#ent", "<e1>", "is", "regulated", "by", "a", "ubiquitin-like", "protein", "C1539895#ent", "<e2>", "."], "h": {"id": "C1335624", "name": "C1335624#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539895", "name": "C1539895#ent", "pos": [13, 14]}}
{"token": ["C1414182#ent", "<e1>", "exhibited", "a", "nuclear-staining", "pattern", "that", "was", "sensitive", "to", "C0035542#ent", "<e2>", "but", "not", "to", "DNase", "I", "suggesting", "that", "C1414182#ent", "<e1>", "in", "the", "cells", "are", "associated", "with", "RNA", "and/or", "ribonucleoprotein", "particles"], "h": {"id": "C1414182", "name": "C1414182#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035542", "name": "C0035542#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "C1419007#ent", "<e1>", "a", "highly", "specialized", "C1335440#ent", "<e2>", "that", "can", "proficiently", "extend", "from", "the", "primer", "ends", "opposite", "DNA", "lesions", "irrespective", "of", "their", "degree", "of", "geometric", "distortion"], "h": {"id": "C1419007", "name": "C1419007#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [7, 8]}}
{"token": ["More", "subjects", "receiving", "C0770559#ent", "<e1>", "systemic", "or", "localized", "adverse", "effects", "those", "receiving", "hydrocortisone", "C0142928#ent", "<e2>"], "h": {"id": "C0770559", "name": "C0770559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0142928", "name": "C0142928#ent", "pos": [13, 14]}}
{"token": ["C0075193#ent", "<e1>", ",", "a", "non-specific", "inhibitor", "of", "C1420479#ent", "<e2>", "reduced", "RacQ61-induced", "phosphorylation", "of", "MLC", "by", "about", "58", "%", ",", "at", "the", "maximum", "concentration", "that", "did", "not", "kill", "cells"], "h": {"id": "C0075193", "name": "C0075193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420479", "name": "C1420479#ent", "pos": [7, 8]}}
{"token": ["Blood", "lymphocytes", "different", "individuals", "displayed", "different", "behaviors", "both", "in", "their", "sensitivity", "to", "C3540781#ent", "<e1>", "and", "in", "their", "proliferative", "response", "to", "C0026249#ent", "<e2>", "lectins", "."], "h": {"id": "C3540781", "name": "C3540781#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [20, 21]}}
{"token": ["Muscarine", ",", "8-Br-cAMP", ",", "forskolin", ",", "C1366646#ent", "<e1>", "isoproterenol", ",", "deoxycholate", "and", "C0031669#ent", "<e2>", "stimulated", "the", "incorporation", "of", "32P", "into", "tyrosine", "hydroxylase"], "h": {"id": "C1366646", "name": "C1366646#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [12, 13]}}
{"token": ["C0304516#ent", "<e1>", "as", "propranolol", ",", "oxprenolol", "and", "C0032896#ent", "<e2>", "have", "been", "asssociated", "with", "numerous", "adverse", "reactions"], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032896", "name": "C0032896#ent", "pos": [7, 8]}}
{"token": ["C0304516#ent", "<e1>", "alprenolol", ",", "propranolol", "and", "C0032896#ent", "<e2>", "were", "given", "as", "a", "prophylactic", "measure", "patients", "undergoing", "middle-ear", "microsurgery", "adrenaline", "was", "deliberately", "infiltrated", "during", "halothane-N2O/O2", "anaesthesia", "."], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032896", "name": "C0032896#ent", "pos": [6, 7]}}
{"token": ["In", "the", "management", "of", "a", "child", "with", "C0002895#ent", "<e1>", "iron", "administration", "not", "recommended", "unless", "there", "is", "evidence", "of", "coexisting", "C0240066#ent", "<e2>"], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0240066", "name": "C0240066#ent", "pos": [19, 20]}}
{"token": ["These", "data", "support", "the", "hypothesis", "that", "C0206064#ent", "<e1>", "associated", "to", "changes", "in", "C3888088#ent", "<e2>", "proliferation", "and", "endothelial", "dysfunction", "which", "could", "be", "involved", "in", "the", "onset", "or", "progression", "of", "the", "atherogenic", "process", "."], "h": {"id": "C0206064", "name": "C0206064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "of", "this", "preliminary", "study", "was", "to", "investigate", "whether", "C1413789#ent", "<e1>", "of", "motor", "cortex", "have", "any", "beneficial", "effect", "in", "patients", "with", "C1862939#ent", "<e2>", "ALS", ")", "."], "h": {"id": "C1413789", "name": "C1413789#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1862939", "name": "C1862939#ent", "pos": [22, 23]}}
{"token": ["The", "effects", "of", "(", "ASE", ")", ",", "and", "retinoic", "acids", "RAs", ")", "and", "their", "precursors", "on", "the", "phenobarbital", "(PB)-mediated", "induction", "of", "CYP2B1", "and", "C1854150#ent", "<e1>", "were", "examined", "in", "cultured", "rat", "C0669372#ent", "<e2>", "."], "h": {"id": "C1854150", "name": "C1854150#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [30, 31]}}
{"token": ["This", "C0039082#ent", "<e1>", ",", "observed", "mainly", "with", "C0033229#ent", "<e2>", "and", "uncommonly", "with", "twenty", "other", "drugs", ",", "is", "characterized", "by", "the", "progressive", "disappearance", "of", "small", "bile", "ducts", "by", "manifestations", "mimicking", "primary", "biliary", "cirrhosis"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033229", "name": "C0033229#ent", "pos": [7, 8]}}
{"token": ["C1327830#ent", "<e1>", "treatment", "also", "suppresses", "the", "phosphorylation", "of", "C0244988#ent", "<e2>", ",", "ribosomal", "protein", "S6(S240/244", ")", ",", "and", "AKT(Thr308", ")", "."], "h": {"id": "C1327830", "name": "C1327830#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [8, 9]}}
{"token": ["In", "patients", "with", "radiological", "evidence", "of", "C0034067#ent", "<e1>", "bronchodilator", "drugs", "fenoterol", "and", "C0027235#ent", "<e2>", "a", "considerable", "increase", "in", "vital", "capacity", "reduction", "in", "residual", "volume", "."], "h": {"id": "C0034067", "name": "C0034067#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0027235", "name": "C0027235#ent", "pos": [12, 13]}}
{"token": ["These", "results", "demonstrate", "that", "the", "pathways", "used", "by", "C0534519#ent", "<e1>", "and", "tumor", "necrosis", "factor-alpha", "induce", "adhesion", "molecule", "expression", "are", "antagonized", "by", "C0010531#ent", "<e2>", "kinase-mediated", "signaling", "pathways"], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010531", "name": "C0010531#ent", "pos": [21, 22]}}
{"token": ["These", "C0014996#ent", "<e1>", "show", "chromatographic", "properties", "very", "similar", "to", "those", "of", "the", "C1136365#ent", "<e2>", "Hpd", "."], "h": {"id": "C0014996", "name": "C0014996#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1136365", "name": "C1136365#ent", "pos": [12, 13]}}
{"token": ["A", "51-year-old", "man", "has", "been", "sequentially", "treated", "for", "two", "years", "with", "atenolol", ",", "indapamide", ",", "enalapril", ",", "and", "C0118168#ent", "<e1>", "due", "to", "C0020538#ent", "<e2>"], "h": {"id": "C0118168", "name": "C0118168#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [22, 23]}}
{"token": ["Chromatin", "immunoprecipitation", "assays", "that", "the", "recruitment", "of", "C1335193#ent", "<e1>", "to", "the", "promoter", "induced", "C3829685#ent", "<e2>", "H4", "hyperacetylation", "chromatin", "."], "h": {"id": "C1335193", "name": "C1335193#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3829685", "name": "C3829685#ent", "pos": [13, 14]}}
{"token": ["The", "computational", "structure", "also", "shows", "the", "interactive", "region", "C1413285#ent", "<e1>", "the", "T-loop", "of", "Cdk5", ",", "a", "critical", "region", "C3640794#ent", "<e2>", "which", "functions", "as", "a", "gate-control-lever", "of", "the", "catalytic", "cleft"], "h": {"id": "C1413285", "name": "C1413285#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3640794", "name": "C3640794#ent", "pos": [18, 19]}}
{"token": ["In", "addition", "to", "the", "daily", "injection", "of", "C1705969#ent", "<e1>", ",", "a", "single", "intraperitoneal", "injection", "of", "C1539862#ent", "<e2>", "was", "also", "given", "on", "d", "13", "of", "pregnancy", "in", "the", "Cd+STZ-treated", "group", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539862", "name": "C1539862#ent", "pos": [15, 16]}}
{"token": ["The", "most", "striking", "observation", "in", "the", "present", "study", "is", "that", "ABU-LAO", "causes", "severe", "pneumorrhagia", ",", "C0748120#ent", "<e1>", "fusion", "of", "pulmonary", "alveoli", "C0013604#ent", "<e2>", "bleeding", "when", "being", "intravenously", "injected", "into", "BALB/c", "mice"], "h": {"id": "C0748120", "name": "C0748120#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [21, 22]}}
{"token": ["In", "study", "2", "we", "assessed", "the", "C2926735#ent", "<e1>", "of", "action", "of", "sustained-release", "C0042523#ent", "<e2>", "(", "240", "mg", "once", "daily", ")", "in", "14", "patients", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [12, 13]}}
{"token": ["This", "oligosaccharide-specific", "reaction", "can", "be", "competed", "out", "by", "adding", "excess", "C0053413#ent", "<e1>", "without", "affecting", "C0015278#ent", "<e2>", "reactivity", "."], "h": {"id": "C0053413", "name": "C0053413#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0015278", "name": "C0015278#ent", "pos": [14, 15]}}
{"token": ["In", "recent-onset", "C0004238#ent", "<e1>", ",", "sotalol", "was", "more", "effective", ",", "whereas", "in", "chronic", "AF", "C0034414#ent", "<e2>", "had", "a", "better", "result", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [14, 15]}}
{"token": ["The", "coordinated", "action", "of", "C0062773#ent", "<e1>", "HATs", ")", "and", "C0059946#ent", "<e2>", "chromatin", "remodeling", "enzymes", "in", "promoter-dependent", "transcription", "initiation", "represents", "a", "paradigm", "for", "how", "epigenetic", "information", "regulates", "gene", "expression"], "h": {"id": "C0062773", "name": "C0062773#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [9, 10]}}
{"token": ["alpha-Adrenergic", "antagonists", "the", "ligand", "mimetic", "peptide", "RGDS", ",", "C0043167#ent", "<e1>", "PTX", ")", ",", "or", "C0013618#ent", "<e2>", ",", "they", "all", "prevented", "the", "alpha-adrenergic", "stimulation", "adhesion", "and", "aggregation", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [14, 15]}}
{"token": ["Interestingly", ",", "the", "previously", "described", "potent", "inhibitors", "of", "C1335233#ent", "<e1>", ",", "cyanine", "863", ",", "quinine", ",", "and", "C0282372#ent", "<e2>", "were", "substrates", "themselves", "."], "h": {"id": "C1335233", "name": "C1335233#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0282372", "name": "C0282372#ent", "pos": [17, 18]}}
{"token": ["In", "summary", ",", "while", "neither", "1B4", "M", "nor", "C0088359#ent", "<e1>", "was", "equally", "stable", "for", "111In", "and", "88Y", ",", "the", "C1539479#ent", "<e2>", "of", "88Y-(DOTA)-B3", "could", "be", "closely", "traced", "by", "that", "of", "111In-(1B4M)-B3", "."], "h": {"id": "C0088359", "name": "C0088359#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [19, 20]}}
{"token": ["The", "membrane-spanning", "and", "cytoplasmic", "domains", "C1332714#ent", "<e1>", "and", "CD8", "were", "replaced", "by", "those", "of", "C1423496#ent", "<e2>", "."], "h": {"id": "C1332714", "name": "C1332714#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1423496", "name": "C1423496#ent", "pos": [14, 15]}}
{"token": ["The", "causative", "agent", "American", "foulbrood", "is", "Bacillus", "larvae", "the", "causes", "of", "the", "European", "foulbrood", "diseases", "are", "Streptococcus", "pluton", "Bacillus", "alvei", "the", "causes", "of", "the", "C0036690#ent", "<e1>", "are", "Pseudomonas", "apiseptica", "and", "Escherichia", "coli", "honeybees", "(", "C0939871#ent", "<e2>", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0939871", "name": "C0939871#ent", "pos": [34, 35]}}
{"token": ["The", "present", "study", "was", "undertaken", "to", "determine", "the", "prevalence", "of", "iron", "deficiency", "C0002871#ent", "<e1>", "and", "the", "response", "of", "iron", "supplementation", "C0002895#ent", "<e2>", "tribal", "population", "the", "four", "States", "viz", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [20, 21]}}
{"token": ["Also", ",", "iron", "deficiency", "C0002871#ent", "<e1>", "can", "often", "go", "unnoticed", "because", "the", "C0002895#ent", "<e2>", "patients", "are", "already", "anaemic", "."], "h": {"id": "C0002871", "name": "C0002871#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [12, 13]}}
{"token": ["Aliphatic", "substrates", "were", "hydrolyzed", "at", "a", "rate", "in", "the", "order", "C0040853#ent", "<e1>", ">", "tributyrin", ">", "tripropionin", ",", "and", "C0059747#ent", "<e2>", "ethyl", "formate"], "h": {"id": "C0040853", "name": "C0040853#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0059747", "name": "C0059747#ent", "pos": [18, 19]}}
{"token": ["Mean", "AgNOR", "values", "were", "significantly", "higher", "the", "presence", "of", "C1705526#ent", "<e1>", "expression", "were", "different", "in", "C0699919#ent", "<e2>", "positive", "and", "negative", "tumor", "and", "stromal", "cells"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [15, 16]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "the", "relation", "between", "silver-strained", "nucleolar", "organizer", "regions", "(", "AgNOR", ")", ",", "tumor", "stage", "tumor", "grade", "C1705526#ent", "<e1>", "expression", "with", "C0699919#ent", "<e2>", "transitional", "cell", "carcinoma", "bladder", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0699919", "name": "C0699919#ent", "pos": [27, 28]}}
{"token": ["As", "photoreactive", "groups", "p-benzoyl-phenylalanine", "(", "Bpa", ")", "and", "the", "arylazides", "azidobenzoic", "acid", "(", "ABA", ")", "and", "azidosalicylic", "acid", "C0004057#ent", "<e1>", ")", "were", "attached", "to", "the", "N-terminus", "of", "the", "C1705889#ent", "<e2>", "agonists", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705889", "name": "C1705889#ent", "pos": [28, 29]}}
{"token": ["Neither", "C0051427#ent", "<e1>", "nor", "FLA-63", "inhibited", "the", "effects", "of", "C0058537#ent", "<e2>", ",", "whereas", "p-chlorophenylalanine", "not", "only", "inhibited", "the", "antagonistic", "effect", "of", "C0058537#ent", "<e2>", "on", "the", "EC50", "but", "also", "prevented", "the", "stimulation", "effect", "on", "5-HT", "turnover"], "h": {"id": "C0051427", "name": "C0051427#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058537", "name": "C0058537#ent", "pos": [9, 10]}}
{"token": ["The", "effects", "of", "therapy", "on", "the", "responsiveness", "of", "lymphocyte", "beta-adrenergic", "receptors", "evaluated", "by", "measuring", "cyclic", "AMP", "elevations", "caused", "by", "C0022245#ent", "<e1>", "in", "cells", "isolated", "from", "patients", "treated", "with", "C0043443#ent", "<e2>", "for", "more", "than", "1", "year", "."], "h": {"id": "C0022245", "name": "C0022245#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0043443", "name": "C0043443#ent", "pos": [28, 29]}}
{"token": ["Granulocyte-macrophage", "colony", "formation", "by", "C57BL", "bone", "marrow", "cells", "was", "initiated", "in", "C0026818#ent", "<e1>", "cultures", "either", "by", "the", "C1332791#ent", "<e2>", "GM-CSF", ",", "or", "by", "the", "predominantly", "macrophage", "stimulus", ",", "M-CSF", "."], "h": {"id": "C0026818", "name": "C0026818#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332791", "name": "C1332791#ent", "pos": [17, 18]}}
{"token": ["The", "recombinant", "domains", "been", "crystallized", "in", "30", "%", "C0032483#ent", "<e1>", "PEG", ")", ",", "0.2", "M", "sodium", "acetate", "0.1", "M", "C0772446#ent", "<e2>", "pH", "4.6", "using", "the", "sitting-drop", "vapour-diffusion", "method", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0772446", "name": "C0772446#ent", "pos": [19, 20]}}
{"token": ["The", "clinical", "symptoms", "C1849096#ent", "<e1>", "include", "ataxia", ",", "athetosis", ",", "hypotonia", ",", "hearing", "deficit", "C0029089#ent", "<e2>", ",", "sensory", "neuropathy", "female", "hypogonadism", "and", "epilepsy", "as", "a", "late", "manifestation"], "h": {"id": "C1849096", "name": "C1849096#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0029089", "name": "C0029089#ent", "pos": [14, 15]}}
{"token": ["The", "C1415757#ent", "<e1>", "a", "protein", "that", "is", "highly", "related", "to", "C1527149#ent", "<e2>", "-", "1", ",", "but", "which", "is", "not", "heat-inducible", "."], "h": {"id": "C1415757", "name": "C1415757#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [10, 11]}}
{"token": ["Sites", "of", "in", "vivo", "glycation", "of", "human", "and", "horse", "liver", "C3659502#ent", "<e1>", "identified", "by", "cleavage", "of", "the", "borotritide-treated", "enzyme", "with", "C0960371#ent", "<e2>", ",", "followed", "by", "gas-phase", "sequencing", "of", "the", "resulting", "tritium-labeled", "glycated", "peptides"], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [20, 21]}}
{"token": ["The", "metabolic", "pathways", "by", "the", "NMR", "results", "were", "confirmed", "by", "high", "activities", "of", "the", "C0014442#ent", "<e1>", "GS", ",", "NADH-GOGAT", "and", "ornithine", "carbamoyltransferase", "C1418661#ent", "<e2>", ";", "EC", "2.1.3.3", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418661", "name": "C1418661#ent", "pos": [22, 23]}}
{"token": ["Seven", "C3540809#ent", "<e1>", "patients", "and", "one", "C0270911#ent", "<e2>", "patient", "had", "increased", "staining", "of", "vimentin", "in", "some", "atrophic", "muscle", "fibres"], "h": {"id": "C3540809", "name": "C3540809#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [6, 7]}}
{"token": ["These", "results", "suggest", "that", "both", "Heptest", "and", "C0019139#ent", "<e1>", "be", "used", "to", "monitor", "patients", "receiving", "C0354599#ent", "<e2>", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [7, 8]}, "relation": "chemical_structure_of", "t": {"id": "C0354599", "name": "C0354599#ent", "pos": [15, 16]}}
{"token": ["We", "found", "elevated", "MCT1", "mRNA", "levels", "in", "fresh", "neuroblastoma", "biopsy", "samples", "that", "correlated", "positively", "with", "risk", "of", "C0270075#ent", "<e1>", "amplification", "of", "the", "\"", "C0812327#ent", "<e2>", "MYCN", "."], "h": {"id": "C0270075", "name": "C0270075#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [23, 24]}}
{"token": ["DTPA", ",", "C0054984#ent", "<e1>", ",", "and", "EDTA", "appear", "to", "be", "the", "most", "effective", "C0035064#ent", "<e2>", "of", "those", "tested", "in", "offsetting", "acute", "zinc", "intoxication", "mice", "."], "h": {"id": "C0054984", "name": "C0054984#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}}
{"token": ["Following", "3", "generations", "of", "selection", "with", "50", "mg/kg", "thiabendazole", "the", "number", "of", "C0018889#ent", "<e1>", "removed", "by", "the", "C3536838#ent", "<e2>", "was", "too", "small", "to", "detect", "differences", "between", "treated", "and", "control", "groups"], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C3536838", "name": "C3536838#ent", "pos": [17, 18]}}
{"token": ["One", "field", "strain", "TAS", ")", "was", "isolated", "from", "a", "dairy", "goat", "herd", "had", "experienced", "severe", "C0018889#ent", "<e1>", "despite", "intensive", "C3536838#ent", "<e2>", "usage", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C3536838", "name": "C3536838#ent", "pos": [19, 20]}}
{"token": ["The", "patients", "were", "composed", "of", "18", "patients", "with", "acute", "bacterial", "pneumonia", "bacterial", "infection", "9", "patients", "with", "C0034067#ent", "<e1>", "27", "patients", "with", "C0008677#ent", "<e2>", "10", "patients", "with", "bronchiectasis", "."], "h": {"id": "C0034067", "name": "C0034067#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [21, 22]}}
{"token": ["Step", "3", "agents", ",", "which", "also", "include", "C0010592#ent", "<e1>", "and", "methotrexate", ",", "may", "be", "contemplated", "when", "C0033860#ent", "<e2>", "is", "moderate", "or", "severe", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0033860", "name": "C0033860#ent", "pos": [16, 17]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "test", "the", "inhibitory", "activity", "of", "methanol", "extract", "Euonymus", "alatus", "C1420044#ent", "<e1>", "in", "vitro", "in", "vivo", "evaluate", "its", "possible", "use", "as", "an", "C0935929#ent", "<e2>"], "h": {"id": "C1420044", "name": "C1420044#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [28, 29]}}
{"token": ["Our", "studies", "revealed", "that", "ROR", "alpha1", "C1417822#ent", "<e1>", "specifically", "bind", "to", "the", "human", "and", "mouse", "C0812287#ent", "<e2>", "ROREs", "and", "transactivate", "and", "transrepress", ",", "respectively", ",", "reporter", "constructs", "containing", "the", "ROREs", "."], "h": {"id": "C1417822", "name": "C1417822#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812287", "name": "C0812287#ent", "pos": [15, 16]}}
{"token": ["Inhibition", "of", "ERBB1", "function", "using", "C0919281#ent", "<e1>", "(", "gefitinib", ")", "or", "the", "C0600438#ent", "<e2>", "AG1478", "had", "more", "modest", "effects", "at", "enhancing", "DCA", "lethality", "than", "inhibition", "of", "the", "insulin/IGF-1", "receptor", "function", "."], "h": {"id": "C0919281", "name": "C0919281#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0600438", "name": "C0600438#ent", "pos": [12, 13]}}
{"token": ["Our", "previous", "results", "demonstrated", "that", "C1367456#ent", "<e1>", "binds", "to", "the", "C1419655#ent", "<e2>", "depurinate", "the", "alpha-sarcin/ricin", "loop", "and", "binding", "of", "C1367456#ent", "<e1>", "to", "L3", "was", "critical", "for", "its", "cytotoxicity", "."], "h": {"id": "C1367456", "name": "C1367456#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419655", "name": "C1419655#ent", "pos": [10, 11]}}
{"token": ["Expression", "of", "CoFac2", "in", "yeast", "revealed", "that", "the", "encoded", "C0014442#ent", "<e1>", "acts", "as", "a", "C4082489#ent", "<e2>", "18:2(9Z", ",", "12Z", ")", "to", "calendic", "acid", "18:3(8E", ",", "10E", ",", "12Z", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4082489", "name": "C4082489#ent", "pos": [14, 15]}}
{"token": ["GH", "C0039585#ent", "<e1>", "GHIS", ")", ",", "otherwise", "known", "as", "C0271568#ent", "<e2>", "is", "a", "heterogeneous", "disorder"], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0271568", "name": "C0271568#ent", "pos": [9, 10]}}
{"token": ["The", "bcl-2", "and", "c-myc", "proto-oncogenes", "are", "brought", "into", "juxtaposition", "with", "the", "C0017351#ent", "<e1>", "particular", "B-cell", "lymphomas", "resulting", "in", "high", "levels", "of", "C0669365#ent", "<e2>", "accumulation", "of", "their", "messenger", "RNAs", "."], "h": {"id": "C0017351", "name": "C0017351#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [21, 22]}}
{"token": ["The", "transport", "inhibitor", "4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonate", "C0058041#ent", "<e1>", ")", ",", "acting", "from", "the", "extracellular", "side", "blocks", "C0041236#ent", "<e2>", "cleavage", "at", "K743", "in", "unsealed", "membranes", "by", "inducing", "a", "protease-resistant", "conformation", "."], "h": {"id": "C0058041", "name": "C0058041#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [14, 15]}}
{"token": ["Here", ",", "we", "show", "that", "suppressing", "the", "kinase", "function", "the", "C1414313#ent", "<e1>", "EGFR", ")", "blocks", "the", "activities", "of", "both", "C0021643#ent", "<e2>", "chondroitin", "sulfate", "proteoglycans", "inhibiting", "neurite", "outgrowth"], "h": {"id": "C1414313", "name": "C1414313#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021643", "name": "C0021643#ent", "pos": [19, 20]}}
{"token": ["C0599930#ent", "<e1>", "the", "main", "human", "nicotine", "metabolizing", "C0014442#ent", "<e2>", "coded", "for", "by", "a", "highly", "polymorphic", "gene", "CYP2A6", "."], "h": {"id": "C0599930", "name": "C0599930#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}}
{"token": ["The", "phytochemical", "C0073096#ent", "<e1>", "has", "been", "reported", "to", "induce", "C0919428#ent", "<e2>", ",", "an", "enzyme", "involved", "in", "detoxification", "reactions", "by", "as", "yet", "undetermined", "mechanisms", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919428", "name": "C0919428#ent", "pos": [9, 10]}}
{"token": ["C0003374#ent", "<e1>", "effects", "were", "ranked", "as", "follows", ":", "C0033126#ent", "<e2>", ">", "proguanil", ">", "mefloquine", ">", "quinine", ">", "quinidine", ">", "artemether", ">", "amodiaquine", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [0, 1]}, "relation": "therapeutic_class_of", "t": {"id": "C0033126", "name": "C0033126#ent", "pos": [8, 9]}}
{"token": ["The", "expression", "of", "CAP", "mRNA", "and", "proteins", "are", "increased", "in", "3T3-L1", "adipocytes", "by", "the", "insulin", "C0162830#ent", "<e1>", "thiazolidinedione", "drugs", "which", "are", "activators", "of", "the", "peroxisome", "proliferator-activated", "receptor", "gamma", "C1335238#ent", "<e2>", ")", "."], "h": {"id": "C0162830", "name": "C0162830#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [28, 29]}}
{"token": ["In", "this", "report", "we", "studied", "synapses", "established", "by", "R2", ",", "a", "C0017547#ent", "<e1>", "cholinergic", "neuron", "onto", "neurons", "C3539854#ent", "<e2>", "and", "L11", ",", "and", "a", "group", "of", "left", "upper", "quadrant", "LUQ", ")", "cells", "."], "h": {"id": "C0017547", "name": "C0017547#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539854", "name": "C3539854#ent", "pos": [17, 18]}}
{"token": ["Hybridization", "with", "the", "3", "'", "untranslated", "region", "a", "rat", "C1384510#ent", "<e1>", "that", "round", "spermatids", "higher", "levels", "of", "C1384510#ent", "<e1>", "mRNA", "than", "did", "pachytene", "spermatocytes", "residual", "bodies", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1384510", "name": "C1384510#ent", "pos": [9, 10]}}
{"token": ["C0102947#ent", "<e1>", "was", "much", "less", "effective", "than", "C0030557#ent", "<e2>", "at", "protecting", "dopamine", ",", "but", "equieffective", "with", "respect", "to", "serotonin.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0102947", "name": "C0102947#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030557", "name": "C0030557#ent", "pos": [7, 8]}}
{"token": ["Seventeen", "children", "with", "asthma", "were", "studied", "in", "a", "double-blind", ",", "crossover", ",", "placebo-controlled", "study", "to", "compare", "the", "efficacy", "of", "C0012694#ent", "<e1>", "that", "of", "nedocromil", "sodium", "preventing", "C0004099#ent", "<e2>"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [19, 20]}, "relation": "may_prevent", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [26, 27]}}
{"token": ["This", "decrease", "was", "verified", "by", "differential", "inhibition", "studies", "using", "clorgyline", "and", "C0700467#ent", "<e1>", ",", "specific", "type", "A", "and", "C0003015#ent", "<e2>", "."], "h": {"id": "C0700467", "name": "C0700467#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [18, 19]}}
{"token": ["C1161334#ent", "<e1>", "found", "to", "be", "hydroxylated", "by", "a", "mixture", "of", "C0027021#ent", "<e2>", "(", "MPO", ")", "and", "the", "mycobactericidal", "drug", ",", "isoniazid", "."], "h": {"id": "C1161334", "name": "C1161334#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [10, 11]}}
{"token": ["Northern", "blot", "analysis", "that", "one", "unknown", "C0079429#ent", "<e1>", "and", "eight", "known", "genes", ",", "namely", "C1442491#ent", "<e2>", "L6", "antigen", "annexin", "VIII", "BVL-1", "retrotransposon", "protective", "protein", "replacement", "variant", "3.3", ",", "alpha-catenin", "and", "LPS-binding", "protein", "are", "over-expressed", "in", "invasive", "GC-1spg", "cells", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1442491", "name": "C1442491#ent", "pos": [14, 15]}}
{"token": ["Introduction", "of", "this", "transgene", "into", "mice", "caused", "C0017547#ent", "<e1>", ",", "elevated", "serum", "GH", "levels", ",", "somatotroph", "proliferation", "and", "C0948740#ent", "<e2>"], "h": {"id": "C0017547", "name": "C0017547#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0948740", "name": "C0948740#ent", "pos": [18, 19]}}
{"token": ["Sequences", "in", "C1538092#ent", "<e1>", ",", "the", "most", "C1512488#ent", "<e2>", "pestiviruses", ",", "showed", "similarity", "to", "six", "sequence", "motifs", "found", "conserved", "in", "helicase-like", "proteins", "by", "eIF-4A", "."], "h": {"id": "C1538092", "name": "C1538092#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [7, 8]}}
{"token": ["In", "this", "study", ",", "we", "have", "used", "a", "C0034857#ent", "<e1>", "part", "of", "the", "epsilon", "subunit", "the", "C1439292#ent", "<e2>", "generate", "a", "novel", "monoclonal", "antibody", "NCL-CD3-PS1", ")", "effective", "in", "paraffin", "sections", "."], "h": {"id": "C0034857", "name": "C0034857#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1439292", "name": "C1439292#ent", "pos": [16, 17]}}
{"token": ["The", "C1412821#ent", "<e1>", "GTP", "cyclohydrolase", "I", "not", "affected", "by", "the", "C3540628#ent", "<e2>", "mutation", "as", "shown", "by", "sequencing", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3540628", "name": "C3540628#ent", "pos": [10, 11]}}
{"token": ["The", "enzyme", "propanediol", "oxidoreductase", ",", "which", "converts", "the", "lactaldehyde", "formed", "in", "the", "metabolism", "of", "fucose", "and", "rhamnose", "into", "C0072225#ent", "<e1>", "under", "anaerobic", "conditions", ",", "was", "investigated", "in", "Escherichia", "coli", "C0519030#ent", "<e2>", "Salmonella", "typhimurium"], "h": {"id": "C0072225", "name": "C0072225#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0519030", "name": "C0519030#ent", "pos": [29, 30]}}
{"token": ["Postoperative", "complications", "included", "one", "death", "due", "to", "C0085605#ent", "<e1>", "two", "cases", "of", "acute", "pneumonitis", "and", "one", "persistent", "C2364135#ent", "<e2>", "the", "trocar", "sites"], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [17, 18]}}
{"token": ["Accordingly", ",", "increasing", "the", "brain", "extracellular", "concentration", "of", "this", "metabolite", "may", "be", "a", "suitable", "alternative", "to", "administration", "of", "exogenous", "C0022614#ent", "<e1>", "antagonists", "for", "the", "treatment", "of", "C0042075#ent", "<e2>", "excessive", "NMDA-receptor", "activation", "."], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0042075", "name": "C0042075#ent", "pos": [26, 27]}}
{"token": ["Either", "IV", "C0022635#ent", "<e1>", "or", "saline", "was", "administered", "in", "addition", "to", "an", "epidural", "C0162792#ent", "<e2>", "infusion", ",", "which", "was", "adjusted", "as", "required", "clinically", "."], "h": {"id": "C0022635", "name": "C0022635#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0162792", "name": "C0162792#ent", "pos": [13, 14]}}
{"token": ["Complications", "included", "abscess", "formation", "nine", ")", ",", "spontaneous", "rupture", "the", "auditory", "canal", "five", ")", ",", "C0376175#ent", "<e1>", "two", ")", ",", "and", "C0036690#ent", "<e2>", "and", "osteomyelitis", "with", "septic", "arthritis", "one", "each", ")", "."], "h": {"id": "C0376175", "name": "C0376175#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [21, 22]}}
{"token": ["C1412102#ent", "<e1>", "significantly", "decreased", "M-stimulated", "C1333673#ent", "<e2>", "secretion", "(", "1", "mg/kg", ",", "i.a", ".", ")"], "h": {"id": "C1412102", "name": "C1412102#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333673", "name": "C1333673#ent", "pos": [5, 6]}}
{"token": ["We", "have", "purified", "three", "NifS", "C4277608#ent", "<e1>", "from", "Escherichia", "coli", "CSD", ",", "C1823882#ent", "<e2>", ",", "and", "IscS", ",", "that", "appear", "to", "be", "involved", "in", "iron-sulfur", "cluster", "formation", "the", "biosynthesis", "of", "selenophosphate", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1823882", "name": "C1823882#ent", "pos": [12, 13]}}
{"token": ["In", "addition", "to", "iscS", ",", "E.", "coli", "two", "other", "nifS", "C4277608#ent", "<e1>", ",", "csdA", "and", "C1823882#ent", "<e2>", ",", "each", "of", "which", "has", "cysteine", "desulfurase", "activity", "and", "could", "potentially", "donate", "sulfur", "for", "thionucleoside", "biosynthesis"], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1823882", "name": "C1823882#ent", "pos": [15, 16]}}
{"token": ["These", "findings", "suggest", "that", "the", "inflammatory", "response", "which", "is", "in", "part", "mediated", "by", "C0669372#ent", "<e1>", "and", "TNF-alpha", ",", "may", "contribute", "to", "neurodegeneration", "following", "C0014053#ent", "<e2>"], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014053", "name": "C0014053#ent", "pos": [23, 24]}}
{"token": ["By", "contrast", ",", "low", "levels", "of", "C1333522#ent", "<e1>", "expression", "markedly", "reduced", "CRAG", "degradation", ",", "while", "an", "C0221406#ent", "<e2>", "of", "C1333522#ent", "<e1>", "greatly", "stimulated", "this", "process", "."], "h": {"id": "C1333522", "name": "C1333522#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [16, 17]}}
{"token": ["Its", "homology", "to", "the", "C1336804#ent", "<e1>", "which", "includes", "several", "C0086376#ent", "<e2>", "with", "mesoderm-inducing", "activity", ",", "suggests", "a", "role", "for", "Vg1", "as", "an", "endogenous", "mesoderm-inducing", "factor", "."], "h": {"id": "C1336804", "name": "C1336804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["The", "ultimobranchial", "gland", "C1421235#ent", "<e1>", ")", "of", "birds", "is", "particularly", "rich", "in", "C1367551#ent", "<e2>", ",", "the", "hypocalcaemic", "hypophosphataemic", "hormone", "that", "is", "secreted", "by", "the", "C-cells", "of", "the", "mammalian", "thyroid", "."], "h": {"id": "C1421235", "name": "C1421235#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367551", "name": "C1367551#ent", "pos": [12, 13]}}
{"token": ["C0031463#ent", "<e1>", "dose-dependently", "decreased", "cyclic", "3',5'-AMP", "levels", "and", "C0017346#ent", "<e2>", "secretion", "both", "in", "unstimulated", "and", "PGE1", "stimulated", "cells", "."], "h": {"id": "C0031463", "name": "C0031463#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [8, 9]}}
{"token": ["The", "second", "leaflet", "consisted", "of", "the", "anionic", "phospholipid", "phosphatidylglycerol", "PG", ")", ",", "in", "either", "the", "C0919289#ent", "<e1>", "or", "liquid", "phase", ",", "for", "comparison", ",", "of", "C3810569#ent", "<e2>", "."], "h": {"id": "C0919289", "name": "C0919289#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3810569", "name": "C3810569#ent", "pos": [25, 26]}}
{"token": ["The", "C0678928#ent", "<e1>", "dominant", "form", "of", "CMT", "(", "C0393808#ent", "<e2>", ")", "is", "associated", "with", "mutations", "in", "the", "connexin32", "gene", "(", "Cx32", ")", "."], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0393808", "name": "C0393808#ent", "pos": [8, 9]}}
{"token": ["The", "C0678928#ent", "<e1>", "dominant", "form", "of", "CMT", "(", "C0393808#ent", "<e2>", ")", "is", "associated", "with", "mutations", "in", "the", "gene", "for", "the", "gap", "junction", "protein", "connexin32", "."], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0393808", "name": "C0393808#ent", "pos": [8, 9]}}
{"token": ["Cellular", "ligands", "hL-31", "were", "found", "to", "be", "composed", "of", "the", "two", "lysosome-associated", "membrane", "proteins", "LAMP-1", "and", "C3890213#ent", "<e1>", ",", "while", "secreted", "ligands", "consisted", "of", "two", "C0072522#ent", "<e2>", "of", "98", "and", "70", "kDa", "."], "h": {"id": "C3890213", "name": "C3890213#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [25, 26]}}
{"token": ["The", "efficacy", "of", "C0033978#ent", "<e1>", "combination", "with", "antihistaminics", "or", "antiallergics", "in", "patients", "with", "C0042109#ent", "<e2>", "investigated", "."], "h": {"id": "C0033978", "name": "C0033978#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042109", "name": "C0042109#ent", "pos": [13, 14]}}
{"token": ["The", "other", "five", "patients", "had", "either", "C0024799#ent", "<e1>", "the", "basis", "of", "dermatoses", "(", "C0011616#ent", "<e2>", "eczema", ",", "or", "bullous", "pemphigoid", "or", "contact", "ulcers", "to", "face-plate", "pressure", "and", "parastomal", "dermatitis"], "h": {"id": "C0024799", "name": "C0024799#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011616", "name": "C0011616#ent", "pos": [13, 14]}}
{"token": ["C0919477#ent", "<e1>", ")", "is", "a", "C3853652#ent", "<e2>", "plays", "an", "important", "role", "in", "both", "T-cell", "maturation", "activation", "."], "h": {"id": "C0919477", "name": "C0919477#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853652", "name": "C3853652#ent", "pos": [5, 6]}}
{"token": ["Therefore", "it", "is", "no", "surprise", ",", "that", "allergic", "diseases", "the", "skin", "are", "the", "most", "often", "diagnosed", "C0037274#ent", "<e1>", "as", "urticaria", ",", "angioedema", ",", "vasculitis", ",", "C0011616#ent", "<e2>", "atopic", "dermatitis"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0011616", "name": "C0011616#ent", "pos": [25, 26]}}
{"token": ["Oxidative", "stress", "inflammation", "have", "recently", "been", "linked", "to", "cutaneous", "damage", "T-lymphocyte", "mediated", "C0037274#ent", "<e1>", "particularly", "in", "C0011616#ent", "<e2>"], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0011616", "name": "C0011616#ent", "pos": [16, 17]}}
{"token": ["Compounds", "selected", "for", "evaluation", "were", "C0050537#ent", "<e1>", "mitomycin", "C", "cyclophosphamide", ",", "colchicine", ",", "6-mercaptopurine", ",", "and", "C0015133#ent", "<e2>", "."], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [16, 17]}}
{"token": ["We", "also", "showed", "that", "C4283933#ent", "<e1>", "may", "stimulate", "C1420214#ent", "<e2>", "expression", "but", "that", "there", "likely", "exist", "faster-acting", "transcriptional", "regulators", "C1420214#ent", "<e2>", "that", "are", "in", "place", "as", "a", "function", "of", "experience", "."], "h": {"id": "C4283933", "name": "C4283933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420214", "name": "C1420214#ent", "pos": [8, 9]}}
{"token": ["C3711161#ent", "<e1>", "ABC", ")", "transporters", "are", "C0021699#ent", "<e2>", "utilise", "the", "energy", "of", "ATP", "hydrolysis", "to", "translocate", "solutes", "across", "cellular", "membranes", "all", "phyla", "."], "h": {"id": "C3711161", "name": "C3711161#ent", "pos": [0, 1]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}}
{"token": ["Although", "there", "are", "no", "apparent", "similarities", "between", "the", "phenotypes", "of", "mutations", "in", "the", "C1415316#ent", "<e1>", "flies", "and", "mice", ",", "all", "known", "C1711252#ent", "<e2>", "rescue", "dorsoanterior", "structures", "in", "ventralized", "Xenopus", "embryos"], "h": {"id": "C1415316", "name": "C1415316#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1711252", "name": "C1711252#ent", "pos": [21, 22]}}
{"token": ["It", "was", "concluded", "that", "C2936882#ent", "<e1>", "and", "mutant", "p53", "are", "related", "to", "the", "regulation", "of", "C1704467#ent", "<e2>", "expression", "and", "that", "the", "ability", "to", "prevent", "tumor", "cell", "death", "to", "C1704467#ent", "<e2>", "can", "be", "developed", "by", "breast", "cancers"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [15, 16]}}
{"token": ["Accordingly", ",", "it", "has", "been", "suggested", "that", "C2936882#ent", "<e1>", "exposure", "reduces", "apoptosis", "through", "the", "up-regulation", "of", "the", "anti-apoptosis", "protein", "C1704467#ent", "<e2>", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [19, 20]}}
{"token": ["The", "DU", "healing", "rate", "was", "evaluated", "by", "endoscopy", "and", "the", "C1415692#ent", "<e1>", "status", "by", "rapid", "C0041945#ent", "<e2>", "CLO-test", "and", "14C-urea", "breath", "test", "UBT", ")", "."], "h": {"id": "C1415692", "name": "C1415692#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041945", "name": "C0041945#ent", "pos": [15, 16]}}
{"token": ["The", "in", "vitro", "susceptibilities", "of", "C4049728#ent", "<e1>", "isolates", "to", "C0360390#ent", "<e2>", "similar", "for", "these", "7", "and", "for", "the", "13", "who", "did", "not", "respond", "to", "antimycobacterial", "treatment", "."], "h": {"id": "C4049728", "name": "C4049728#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0360390", "name": "C0360390#ent", "pos": [9, 10]}}
{"token": ["C0700465#ent", "<e1>", "is", "an", "investigational", "type", "Ic", "C0003195#ent", "<e2>", "markedly", "slows", "conduction", "velocity", "in", "all", "cardiac", "tissues"], "h": {"id": "C0700465", "name": "C0700465#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [7, 8]}}
{"token": ["C0700465#ent", "<e1>", "is", "a", "potent", "C0003195#ent", "<e2>", "effective", "in", "either", "supraventricular", "or", "ventricular", "tachyarrhythmias"], "h": {"id": "C0700465", "name": "C0700465#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [5, 6]}}
{"token": ["These", "data", "demonstrate", "that", "sugar", "and", "C0001962#ent", "<e1>", "reduce", "the", "polymerization", "of", "C0035179#ent", "<e2>", "mutants", "that", "cause", "disease", ",", "possibly", "by", "binding", "to", "and", "stabilizing", "beta-sheet", "A."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035179", "name": "C0035179#ent", "pos": [12, 13]}}
{"token": ["The", "emerging", "mechanisms", "comprise", "interactions", "of", "agrin", ",", "integrin", "ligands", "and", "C1419337#ent", "<e1>", ",", "with", "their", "cognate", "cell-surface", "receptors", "coupled", "to", "C0033681#ent", "<e2>", "."], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033681", "name": "C0033681#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "C1413108#ent", "<e1>", "interacts", "with", "NTF2", ",", "associates", "with", "C0034665#ent", "<e2>", "and", "is", "furthermore", "able", "to", "bind", "the", "NTF2-Ran", "complex", "."], "h": {"id": "C1413108", "name": "C1413108#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [11, 12]}}
{"token": ["Blood", "pressure", "ACTH", ",", "and", "cortisol", "increased", "in", "response", "to", "C1854310#ent", "<e1>", ",", "and", "these", "responses", "were", "prevented", "by", "C0060502#ent", "<e2>", "."], "h": {"id": "C1854310", "name": "C1854310#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0060502", "name": "C0060502#ent", "pos": [19, 20]}}
{"token": ["Hematocrit", "decreased", "significantly", "in", "response", "to", "C1854310#ent", "<e1>", "but", "only", "following", "C0060502#ent", "<e2>", "treatment", "."], "h": {"id": "C1854310", "name": "C1854310#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0060502", "name": "C0060502#ent", "pos": [11, 12]}}
{"token": ["Challenge", "of", "these", "mice", "with", "shigatoxin", "(", "derived", "from", "bacterial", "pathogens", "associated", "with", "related", "human", "disease", "C1268936#ent", "<e1>", "resulted", "in", "a", "striking", "C0039082#ent", "<e2>", "closely", "resembling", "human", "TTP", "."], "h": {"id": "C1268936", "name": "C1268936#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [22, 23]}}
{"token": ["This", "study", "investigates", "the", "source", "of", "the", "C0376261#ent", "<e1>", "and", "examines", "the", "effect", "of", "C0770893#ent", "<e2>", "on", "glucose", "metabolism", "the", "intestine", "and", "liver", "of", "rats", "."], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [14, 15]}}
{"token": ["Circulating", "C0376261#ent", "<e1>", "concentrations", "increased", "during", "the", "regimen", "including", "C0770893#ent", "<e2>", ",", "but", "they", "remained", "well", "within", "the", "reference", "values", "normal", "subjects"], "h": {"id": "C0376261", "name": "C0376261#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [9, 10]}}
{"token": ["We", "treated", "14", "patients", "with", "C0036416#ent", "<e1>", "with", "intermittent", "pulse", "doses", "intravenous", "C0360556#ent", "<e2>", "."], "h": {"id": "C0036416", "name": "C0036416#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0360556", "name": "C0360556#ent", "pos": [12, 13]}}
{"token": ["At", "a", "constant", "flow", "rate", "with", "a", "contact", "time", "limited", "to", "few", "seconds", ",", "C2240523#ent", "<e1>", "filtered", "through", "C2350558#ent", "<e2>", "trypsin", "."], "h": {"id": "C2240523", "name": "C2240523#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [18, 19]}}
{"token": ["The", "highest", "doses", "of", "C0030438#ent", "<e1>", "were", "cytotoxic", "and", "reduced", "the", "C1420713#ent", "<e2>", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420713", "name": "C1420713#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "C1705556#ent", "<e1>", "analogues", "on", "phosphatidylcholine", "secretion", "also", "inhibited", "by", "the", "C0016411#ent", "<e2>", "with", "the", "greatest", "degree", "of", "inhibition", "being", "observed", "with", "the", "analogue", "that", "increased", "cAMP", "to", "the", "greatest", "extent", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016411", "name": "C0016411#ent", "pos": [13, 14]}}
{"token": ["Similarly", ",", "direct", "reduction", "of", "C1705556#ent", "<e1>", "by", "various", "combinations", "of", "C0016411#ent", "<e2>", "by", "ouabain", "was", "closely", "paralleled", "by", "loss", "of", "phosphoCx43", "and", "recovery", "of", "phosphoCx43", "accompanied", "restoration", "of", "C1705556#ent", "<e1>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016411", "name": "C0016411#ent", "pos": [11, 12]}}
{"token": ["Higher", "doses", "of", "irradiation", "at", ">", "1", "Gy", "accumulated", "C1705526#ent", "<e1>", "induced", "phosphorylation", "of", "C4082284#ent", "<e2>", "ERK", ")", "1/2", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [14, 15]}}
{"token": ["These", "results", "demonstrate", "that", "cJun", "and", "C1705123#ent", "<e1>", "are", "crucial", "C0127400#ent", "<e2>", "of", "the", "Ras-transformation", "process", "."], "h": {"id": "C1705123", "name": "C1705123#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [10, 11]}}
{"token": ["TLC", "spray", "reagents", "that", "the", "component", "was", "a", "sterol", ",", "terpene", "or", "C0242209#ent", "<e1>", "but", "not", "a", "C2348680#ent", "<e2>", ",", "while", "the", "pigmented", "nature", "suggested", "a", "carotenoid", "."], "h": {"id": "C0242209", "name": "C0242209#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2348680", "name": "C2348680#ent", "pos": [17, 18]}}
{"token": ["C0812198#ent", "<e1>", "an", "important", "C1332323#ent", "<e2>"], "h": {"id": "C0812198", "name": "C0812198#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332323", "name": "C1332323#ent", "pos": [4, 5]}}
{"token": ["When", "the", "C1704867#ent", "<e1>", "promoter", "was", "derepressed", ",", "cells", "containing", "the", "complete", "C1426113#ent", "<e2>", "to", "show", "any", "significant", "growth", ",", "suggesting", "that", "Rap1p", "is", "toxic", "."], "h": {"id": "C1704867", "name": "C1704867#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1426113", "name": "C1426113#ent", "pos": [12, 13]}}
{"token": ["Synergistic", "anti-Candida", "activity", "was", "observed", "between", "egg", "white", "lysozyme", "itraconazole", ",", "C0009074#ent", "<e1>", ",", "miconazole", "and", "C0125333#ent", "<e2>", "."], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0125333", "name": "C0125333#ent", "pos": [16, 17]}}
{"token": ["The", "diagnosis", "of", "C0023003#ent", "<e1>", "sometimes", "be", "confused", "with", "hypohidrotic", "ectodermal", "dysplasia", "C1539327#ent", "<e2>", ")", "."], "h": {"id": "C0023003", "name": "C0023003#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539327", "name": "C1539327#ent", "pos": [12, 13]}}
{"token": ["The", "activities", "of", "DA", "and", "C0701351#ent", "<e1>", "are", "not", "entirely", "the", "same", "as", "that", "of", "C1420262#ent", "<e2>", "."], "h": {"id": "C0701351", "name": "C0701351#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420262", "name": "C1420262#ent", "pos": [15, 16]}}
{"token": ["C0034282#ent", "<e1>", "(", "[3H]-pyrilamine", ")", "has", "a", "high", "affinity", "for", "C3711338#ent", "<e2>", "CYP2D1", ")", "in", "rat", "liver", "microsomes", ",", "the", "isoenzyme", "involved", "in", "the", "oxidative", "metabolism", "debrisoquine", "."], "h": {"id": "C0034282", "name": "C0034282#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3711338", "name": "C3711338#ent", "pos": [10, 11]}}
{"token": ["Deletion", "of", "the", "carboxyl-terminal", "tail", "NF-H", "shows", "that", "this", "region", "is", "not", "essential", "for", "coassembly", "with", "C1421451#ent", "<e1>", "but", "is", "important", "for", "coassembly", "with", "C2981619#ent", "<e2>", "into", "an", "extensive", "filamentous", "network", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2981619", "name": "C2981619#ent", "pos": [24, 25]}}
{"token": ["Interestingly", ",", "ligation", "of", "the", "C0524889#ent", "<e1>", "complex", "with", "anti-CD3", "mAb", "phosphorylated", "C1334468#ent", "<e2>", ",", "but", "failed", "to", "induce", "interaction", "between", "C1334468#ent", "<e2>", "and", "Smad4", "in", "the", "Jurkat", "T", "cell", "line"], "h": {"id": "C0524889", "name": "C0524889#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334468", "name": "C1334468#ent", "pos": [12, 13]}}
{"token": ["These", "results", "indicate", "that", "manganese", "is", "involved", "in", "arterial", "C0017346#ent", "<e1>", "metabolism", "by", "affecting", "the", "C1412719#ent", "<e2>", "that", "changes", "in", "C0017346#ent", "<e1>", "concentration", "and", "composition", "with", "manganese", "deficiency", "ultimately", "affect", "arterial", "wall", "integrity", "subsequently", "cardiovascular", "health"], "h": {"id": "C0017346", "name": "C0017346#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412719", "name": "C1412719#ent", "pos": [15, 16]}}
{"token": ["However", ",", "C0259419#ent", "<e1>", "not", "overcome", "gametogenic", "failure", "from", "meiotic", "recombination", "defects", "in", "C0919524#ent", "<e2>", "Atm", ")", "null", "female", "mice", "."], "h": {"id": "C0259419", "name": "C0259419#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919524", "name": "C0919524#ent", "pos": [13, 14]}}
{"token": ["A", "double-blind", ",", "placebo-controlled", "multicenter", "study", "34", "centers", "from", "different", "Brazilian", "regions", "was", "performed", "to", "evaluate", "the", "antihypertensive", "efficacy", "tolerability", "of", "C0076891#ent", "<e1>", ",", "an", "angiotensin", "I", "enzyme", "inhibitor", "in", "the", "treatment", "of", "mild-to-moderate", "C0020538#ent", "<e2>"], "h": {"id": "C0076891", "name": "C0076891#ent", "pos": [21, 22]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [34, 35]}}
{"token": ["Two", "isoforms", "of", "the", "C3889259#ent", "<e1>", "FLIP", ")", "short", "(", "FLIPS", ")", "and", "C3272498#ent", "<e2>", "FLIPL", ")", ",", "which", "modulate", "TRAIL", "signals", ",", "showed", "disease-stage-dependent", "differential", "regulation", "."], "h": {"id": "C3889259", "name": "C3889259#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3272498", "name": "C3272498#ent", "pos": [13, 14]}}
{"token": ["These", "human", "monoclonal", "antibodies", "C1416970#ent", "<e1>", "appear", "different", "from", "the", "C0258855#ent", "<e2>", "by", "serological", "approaches", "by", "most", "mouse", "monoclonal", "antibodies"], "h": {"id": "C1416970", "name": "C1416970#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0258855", "name": "C0258855#ent", "pos": [10, 11]}}
{"token": ["Our", "finding", "suggests", "that", "the", "treatment", "of", "C0014241#ent", "<e1>", "its", "inhibitor", "destroys", "the", "C1420044#ent", "<e2>", "ability", "on", "an", "in", "vitro", "growth", "test", "."], "h": {"id": "C0014241", "name": "C0014241#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420044", "name": "C1420044#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "normal", "GH", "response", "to", "C1333674#ent", "<e1>", "in", "DS", "indicates", "normal", "pituitary", "function", "normal", "somatotroph", "response", "to", "C1333674#ent", "<e1>", ")", "and", "supports", "C0751230#ent", "<e1>", "DS", "."], "h": {"id": "C1333674", "name": "C1333674#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751230", "name": "C0751230#ent", "pos": [23, 24]}}
{"token": ["Consistent", "with", "observation", ",", "C2350558#ent", "<e1>", ",", "purified", "ICAM-2", ",", "a", "specific", "counter-receptor", "for", "C1706332#ent", "<e2>", ",", "did", "not", "support", "the", "adhesion-dependent", "phase", "of-superoxide", "production", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706332", "name": "C1706332#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "vanadate", "is", "an", "effective", "inhibitor", "of", "many", "ATPases", ",", "C0031727#ent", "<e1>", ",", "lyases", ",", "and", "C0524926#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0524926", "name": "C0524926#ent", "pos": [18, 19]}}
{"token": ["The", "C0008385#ent", "<e1>", "level", "in", "the", "monocytes", "of", "C0003872#ent", "<e2>", "patients", "was", "high", ",", "but", "this", "does", "not", "seem", "to", "play", "an", "important", "role", "in", "the", "pathogenesis", "of", "psoriasis", "."], "h": {"id": "C0008385", "name": "C0008385#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [8, 9]}}
{"token": ["Some", "cells", "were", "treated", "with", "siRNA", "to", "paxillin", "or", "C0059239#ent", "<e1>", ",", "or", "the", "Src", "inhibitor", "C1417819#ent", "<e2>", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417819", "name": "C1417819#ent", "pos": [16, 17]}}
{"token": ["C4255437#ent", "<e1>", "to", "recapitulate", "the", "normal", "C2986638#ent", "<e2>", "development", "to", "the", "point", "that", "the", "more", "mature", "neoplastic", "cells", "represent", "terminally", "differentiated", "elements", "withdrawn", "from", "cell", "cycle"], "h": {"id": "C4255437", "name": "C4255437#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2986638", "name": "C2986638#ent", "pos": [6, 7]}}
{"token": ["Sternal", "abnormalities", "sickle-cell", "disease", "been", "documented", "by", "bone", "scintigraphy", "radiography", "in", "patients", "with", "C0002895#ent", "<e1>", "but", "not", "in", "patients", "with", "C2242796#ent", "<e2>", "."], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C2242796", "name": "C2242796#ent", "pos": [20, 21]}}
{"token": ["C0040921#ent", "<e1>", ",", "bacterial", "vaginosis", "BV", ")", "and", "candidiasis", "are", "C1171315#ent", "<e2>", "RTIs", ")", "of", "the", "vagina", "."], "h": {"id": "C0040921", "name": "C0040921#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1171315", "name": "C1171315#ent", "pos": [10, 11]}}
{"token": ["C0024530#ent", "<e1>", "ranks", "with", "C0041296#ent", "<e2>", "and", "AIDS", "in", "terms", "of", "its", "ability", "to", "destroy", "human", "health", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [4, 5]}}
{"token": ["It", "appears", "that", "only", "betahistine", "and", "C0012798#ent", "<e1>", "have", "a", "proven", "effect", "in", "double-blind", "studies", "long-term", "control", "of", "C0042571#ent", "<e2>", "in", "Meni\u00e8re's", "disease"], "h": {"id": "C0012798", "name": "C0012798#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042571", "name": "C0042571#ent", "pos": [18, 19]}}
{"token": ["These", "IC(50", ")", "values", "are", "comparable", "or", "superior", "to", "those", "for", "C0216660#ent", "<e1>", "and", "oseltamivir", ",", "C0991617#ent", "<e2>", "recently", "approved", "by", "the", "FDA", "for", "treatment", "of", "influenza", "."], "h": {"id": "C0216660", "name": "C0216660#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}}
{"token": ["Verapamil", "appears", "to", "be", "a", "safe", "and", "effective", "treatment", "alternative", "to", "propranolol", "for", "relieving", "anginal", "symptoms", "improving", "exercise", "tolerance", "and", "reducing", "elevated", "systemic", "blood", "pressure", "patients", "with", "both", "C0340288#ent", "<e1>", "mild", "to", "moderate", "C0221155#ent", "<e2>"], "h": {"id": "C0340288", "name": "C0340288#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C0221155", "name": "C0221155#ent", "pos": [33, 34]}}
{"token": ["In", "present", "study", ",", "HDAC", "inhibitor", "apicidin", "was", "used", "to", "elucidate", "the", "effect", "on", "expression", "of", "cell", "cycle", "proteins", "and", "the", "molecular", "mechanism", "transcriptional", "regulation", "C1413175#ent", "<e1>", "response", "to", "C2001522#ent", "<e2>", "human", "colon", "cancer", "cells"], "h": {"id": "C1413175", "name": "C1413175#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C2001522", "name": "C2001522#ent", "pos": [29, 30]}}
{"token": ["The", "major", "causes", "of", "death", "were", "diseases", "of", "the", "alimentary", "tract", "C0017160#ent", "<e1>", "(", "76/108", ")", "due", "to", "colibacillosis", ",", "salmonellosis", ",", "C1299919#ent", "<e2>", "and", "helminthiasis", ",", "and", "bloat", "(", "20/108", ")", "."], "h": {"id": "C0017160", "name": "C0017160#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1299919", "name": "C1299919#ent", "pos": [22, 23]}}
{"token": ["Superfusion", "with", "C0242561#ent", "<e1>", ",", "a", "competitive", "C0598695#ent", "<e2>", "reversibly", "reduced", "the", "duration", "of", "the", "events", "was", "also", "reduced", "."], "h": {"id": "C0242561", "name": "C0242561#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0598695", "name": "C0598695#ent", "pos": [7, 8]}}
{"token": ["Generalized", "epilepsy", "febrile", "seizures-plus", "C3502809#ent", "<e1>", ")", "is", "a", "benign", "Mendelian", "syndrome", "by", "childhood-onset", "C0015967#ent", "<e2>", "and", "afebrile", "seizures", "."], "h": {"id": "C3502809", "name": "C3502809#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [14, 15]}}
{"token": ["Methylation", "interference", "used", "to", "compare", "the", "contacts", "made", "by", "the", "C0025831#ent", "<e1>", "unmodified", ",", "hemimethylated", "or", "fully", "modified", "C0011519#ent", "<e2>", "."], "h": {"id": "C0025831", "name": "C0025831#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [18, 19]}}
{"token": ["C1824738#ent", "<e1>", "has", "four", "promoters", ",", "which", "are", "transcribed", "in", "a", "C1420295#ent", "<e2>"], "h": {"id": "C1824738", "name": "C1824738#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [11, 12]}}
{"token": ["Histochemical", "procedures", "performed", "for", "glycogen", ",", "acid", "mucosaccharides", "inorganic", "substances", "and", "enzymes", "including", "alkaline", "phosphatase", "acid", "phosphatase", "beta", "glucuronidase", "C0008429#ent", "<e1>", ",", "aminopeptidase", ",", "oxidases", "and", "C0030016#ent", "<e2>", "."], "h": {"id": "C0008429", "name": "C0008429#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [26, 27]}}
{"token": ["The", "new", "photosensitizer", ",", "meso-tetrahydroxyphenylchlorin", "(", "mTPHC", ")", "was", "compared", "with", "C0729236#ent", "<e1>", "in", "the", "murine", "C1538841#ent", "<e2>", "in", "normal", "mouse", "skin", "."], "h": {"id": "C0729236", "name": "C0729236#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1538841", "name": "C1538841#ent", "pos": [16, 17]}}
{"token": ["Ethambutol", "optic", "neuropathy", "a", "well-recognised", "adverse", "ocular", "event", "in", "patients", "who", "receive", "C0546863#ent", "<e1>", "for", "the", "treatment", "of", "C0026918#ent", "<e2>"], "h": {"id": "C0546863", "name": "C0546863#ent", "pos": [12, 13]}, "relation": "may_prevent", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [18, 19]}}
{"token": ["We", "report", "our", "experience", "with", "rapid", "oral", "desensitization", "C0546863#ent", "<e1>", "and", "rifampin", "in", "a", "group", "of", "10", "patients", "with", "C0026918#ent", "<e2>", "had", "experienced", "cutaneous", "hypersensitivity", "reactions", "these", "drugs", "."], "h": {"id": "C0546863", "name": "C0546863#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C0026918", "name": "C0026918#ent", "pos": [19, 20]}}
{"token": ["These", "properties", "distinguish", "C0299456#ent", "<e1>", "from", "all", "other", "known", "C0077678#ent", "<e2>", "and", "we", "speculate", "that", "C0299456#ent", "<e1>", "exerts", "its", "catalytic", "effect", "altering", "Ubc9", "'s", "properties", "rather", "than", "by", "mediating", "target", "interactions", "."], "h": {"id": "C0077678", "name": "C0077678#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0299456", "name": "C0299456#ent", "pos": [3, 4]}}
{"token": ["C0001640#ent", "<e1>", "denervation", "atrophy", "with", "further", "increase", "in", "C0009325#ent", "<e2>", "content", "of", "denervated", "gastrocnemius", "muscle"], "h": {"id": "C0001640", "name": "C0001640#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [8, 9]}}
{"token": ["The", "effect", "of", "these", "agents", "on", "nitrite", "release", "was", "blocked", "by", "L-NAME", ",", "which", "inhibits", "C0132555#ent", "<e1>", "HOE-140", ",", "which", "blocks", "C1332407#ent", "<e2>", "and", "dichloroisocoumarin", ",", "which", "blocks", "kinin-forming", "enzymes"], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1332407", "name": "C1332407#ent", "pos": [21, 22]}}
{"token": ["We", "examined", "the", "effects", "of", "inhibitor", "of", "leukotriene", "biosynthesis", "C0733397#ent", "<e1>", "two", "leukotriene", "antagonists", "FPL-55712", "and", "FPL-57231", ",", "and", "a", "C2936829#ent", "<e2>", "8-phenyltheophylline", ",", "on", "this", "increase", "."], "h": {"id": "C0733397", "name": "C0733397#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2936829", "name": "C2936829#ent", "pos": [20, 21]}}
{"token": ["To", "elucidate", "the", "mechanism(s", ")", "by", "which", "C1336927#ent", "<e1>", ",", "a", "new", "member", "of", "the", "Vav", "family", "proteins", "participates", "in", "B", "cell", "antigen", "receptor", "C0105421#ent", "<e2>", ")", "signaling", ",", "we", "have", "generated", "a", "B", "cell", "line", "deficient", "C1336927#ent", "<e1>", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1336927", "name": "C1336927#ent", "pos": [7, 8]}}
{"token": ["A", "C0021051#ent", "<e1>", "disseminated", "lupus", "erythematosis", "a", "sister", ",", "and", "C0034150#ent", "<e2>", "one", "of", "the", "patient's", "children", "are", "interesting", "features", "of", "this", "text", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034150", "name": "C0034150#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "C2916905#ent", "<e1>", "ibuprofen", ",", "on", "experimentally-induced", "local", "C0013604#ent", "<e2>", "responses", "in", "rabbit", "skin", "were", "investigated", "."], "h": {"id": "C2916905", "name": "C2916905#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [10, 11]}}
{"token": ["Numerical", "values", "properties", "for", "C3536880#ent", "<e1>", "very", "high", "correlation", "with", "the", "values", "from", "C0012315#ent", "<e2>", ",", "barbital", ",", "metharbital", ",", "phenobarbital", ",", "methohexital", ",", "4-aminohex-5-enoic", "acid", ",", "and", "(4-chlorophenyl)(5-fluoro-2-hydroxyphenyl)methanone", "."], "h": {"id": "C3536880", "name": "C3536880#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [13, 14]}}
{"token": ["Our", "conclusion", "is", "that", "C0038792#ent", "<e1>", "is", "a", "very", "useful", "drug", "in", "the", "treatment", "of", "C0003868#ent", "<e2>"], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0003868", "name": "C0003868#ent", "pos": [15, 16]}}
{"token": ["All", "kinds", "of", "the", "compounds", "(", "HCS", ",", "C1423693#ent", "<e1>", ",", "HCSS", ",", "LCSS", ",", "HSACS", ",", "LSACS", ",", "C3641622#ent", "<e2>", ",", "LSACSS", ")", "showed", "stronger", "scavenging", "activity", "hydroxyl", "radical", "ascorbic", "acid", "Vc", ")", "."], "h": {"id": "C1423693", "name": "C1423693#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3641622", "name": "C3641622#ent", "pos": [19, 20]}}
{"token": ["Subepithelial", "deposits", "are", "a", "common", "feature", "of", "C0086445#ent", "<e1>", "MGN", ")", "and", "C0017665#ent", "<e2>", "LMGN", ")", "."], "h": {"id": "C0086445", "name": "C0086445#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0017665", "name": "C0017665#ent", "pos": [12, 13]}}
{"token": ["To", "assess", "the", "effects", "of", "lipid", "lowering", "using", "a", "hydroxymethyl", "glutaryl", "coenzyme", "A", "reductase", "inhibitor", "C0085542#ent", "<e1>", ")", "in", "symptomatic", "men", "with", "C1956346#ent", "<e2>"], "h": {"id": "C0085542", "name": "C0085542#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [22, 23]}}
{"token": ["The", "chimera", "was", "fully", "functional", ",", "and", "associated", "with", "C1418640#ent", "<e1>", "PLC", "gamma", ",", "ras", "GTPase-activating", "protein", "GAP", ")", "and", "the", "non-catalytic", "subunit", "C0089793#ent", "<e2>", ",", "p85", ",", "in", "a", "ligand-dependent", "manner", "."], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [23, 24]}}
{"token": ["The", "vitamin", "D-binding", "protein", "C3813197#ent", "<e1>", ")", ",", "also", "known", "as", "C1367452#ent", "<e2>", "Gc-globulin", ",", "is", "a", "multifunctional", "plasma", "protein", "can", "significantly", "enhance", "the", "leukocyte", "chemotactic", "activity", "to", "C5a", "and", "C5a", "des-Arg"], "h": {"id": "C3813197", "name": "C3813197#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [11, 12]}}
{"token": ["As", "described", "here", ",", "fluorescence", "in", "situ", "hybridization", "FISH", ")", "analysis", "of", "35", "primary", "C0812385#ent", "<e1>", "samples", "with", "cytogenetic", "evidence", "12p", "abnormalities", "hemizygous", "deletions", "C1705523#ent", "<e2>", "in", "29", "cases", "."], "h": {"id": "C0812385", "name": "C0812385#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705523", "name": "C1705523#ent", "pos": [24, 25]}}
{"token": ["Our", "study", "thus", "provides", "the", "first", "functional", "evidence", "of", "C1335654#ent", "<e1>", "transcriptional", "activity", "to", "C0699918#ent", "<e2>", "offers", "novel", "insights", "into", "the", "broader", "biological", "significance", "of", "C1335654#ent", "<e1>", "in", "nonmyeloid", "cells"], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [9, 10]}}
{"token": ["STI571-induced", "downregulation", "of", "C0026900#ent", "<e1>", "mRNA", "was", "prevented", "by", "the", "pretreatment", "of", "K562", "cells", "C0297666#ent", "<e2>", "."], "h": {"id": "C0026900", "name": "C0026900#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0297666", "name": "C0297666#ent", "pos": [14, 15]}}
{"token": ["C1540159#ent", "<e1>", "and", "SR", "interact", "via", "their", "C1512488#ent", "<e2>", "core", "GTPase", "domains", "and", "N-terminal", "four-helix", "bundles", "(", "N", "domains", "."], "h": {"id": "C1540159", "name": "C1540159#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [7, 8]}}
{"token": ["C1428997#ent", "<e1>", "possesses", "an", "C1367731#ent", "<e2>", "to", "STE20", ",", "the", "Saccharomyces", "cerevisiae", "mitogen-activated", "protein", "kinase", "kinase", "kinase", "kinase", "and", "a", "C-terminal", "regulatory", "domain", "termed", "the", "citron", "homology", "(", "CNH", ")", "domain", "."], "h": {"id": "C1428997", "name": "C1428997#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367731", "name": "C1367731#ent", "pos": [4, 5]}}
{"token": ["Betulinic", "acid", "a", "naturally", "occurring", "pentacyclic", "triterpenoid", "has", "been", "shown", "to", "exhibit", "a", "variety", "of", "biological", "activities", "inhibition", "of", "human", "immunodeficiency", "virus", "C0019693#ent", "<e1>", ")", ",", "antibacterial", ",", "antimalarial", ",", "antiinflammatory", ",", "C3536838#ent", "<e2>", "and", "antioxidant", "properties"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C3536838", "name": "C3536838#ent", "pos": [32, 33]}}
{"token": ["Comparative", "studies", "anthranilate", "hydroxylase", "2,3-dihydroxybenzoate", "carboxy-lyase", "and", "C0054859#ent", "<e1>", "that", "these", "C3540790#ent", "<e2>", "were", "not", "coordinately", "induced", "by", "either", "anthranilate", "or", "3-hydroxyanthranilate", "."], "h": {"id": "C0054859", "name": "C0054859#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}}
{"token": ["This", "indicates", "that", "rough", "acts", ",", "similar", "to", "other", "homeobox", "genes", "as", "a", "C1706112#ent", "<e1>", "determines", "the", "C1539479#ent", "<e2>", "of", "single", "cells"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1539479", "name": "C1539479#ent", "pos": [17, 18]}}
{"token": ["Common", "causes", "of", "orofacial", "neuropathic", "pain", "reviewed", "here", ",", "with", "a", "focus", "on", "the", "2", "most", "common", ":", "C0032768#ent", "<e1>", "posttraumatic", "painful", "C0031117#ent", "<e2>"], "h": {"id": "C0032768", "name": "C0032768#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [22, 23]}}
{"token": ["The", "metabolic", "basis", "of", "coumarin", "hepatotoxicity", "and", "its", "modulation", "by", "C0443764#ent", "<e1>", "inducers", ",", "beta-naphthoflavone", "(", "beta", "NF", "and", "aroclor", "1254", "C1705771#ent", "<e2>", ")", ",", "were", "investigated", "in", "C3H/He", "and", "DBA/2", "mice"], "h": {"id": "C0443764", "name": "C0443764#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705771", "name": "C1705771#ent", "pos": [21, 22]}}
{"token": ["The", "C0031179#ent", "<e1>", "tomato", ",", "tap1", "and", "C1704920#ent", "<e2>", ",", "are", "induced", "by", "wounding", "in", "tomato", "fruits", "by", "elicitor", "treatment", "in", "cell", "suspension", "cultures"], "h": {"id": "C0031179", "name": "C0031179#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704920", "name": "C1704920#ent", "pos": [7, 8]}}
{"token": ["We", "have", "recently", "described", "an", "involvement", "of", "C1705660#ent", "<e1>", "into", "the", "Fanconi", "anemia", "FA", ")", "C0596223#ent", "<e2>", "pathway", "through", "recruitment", "of", "FA", "protein", "FANCD2", "to", "the", "sites", "of", "stalled", "replication", "forks", "."], "h": {"id": "C1705660", "name": "C1705660#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0596223", "name": "C0596223#ent", "pos": [15, 16]}}
{"token": ["No", "C1420044#ent", "<e1>", "and", "C0751039#ent", "<e2>", "changes", "were", "found", "in", "the", "inactive", "neck", "muscle", "no", "C1420044#ent", "<e1>", "changes", "in", "the", "mandibular", "bone", "marrow", "p", ">", "0.05", ")", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420044", "name": "C1420044#ent", "pos": [1, 2]}}
{"token": ["Immunocytochemical", "detections", "that", "C0967483#ent", "<e1>", ",", "striatin", "and", "C1423683#ent", "<e2>", "are", "expressed", "in", "neurones", "of", "vagal", ",", "petrosal", "and", "dorsal", "root", "ganglia"], "h": {"id": "C0967483", "name": "C0967483#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423683", "name": "C1423683#ent", "pos": [8, 9]}}
{"token": ["Bromocriptine", ",", "amantadine", ",", "C0010977#ent", "<e1>", "and", "electroconvulsive", "therapy", "been", "used", "effectively", "in", "the", "treatment", "of", "C0027849#ent", "<e2>", "."], "h": {"id": "C0010977", "name": "C0010977#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0027849", "name": "C0027849#ent", "pos": [16, 17]}}
{"token": ["The", "greatest", "enzymatic", "activity", "characteristic", "of", "Candida", "albicans", "isolated", "from", "patients", "with", "stomatitis", "atrophica", "or", "C0038362#ent", "<e1>", "and", "the", "lowest", "in", "strains", "from", "C0017574#ent", "<e2>", "or", "juvenile", "periodontitis", "cases", "."], "h": {"id": "C0038362", "name": "C0038362#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017574", "name": "C0017574#ent", "pos": [23, 24]}}
{"token": ["The", "results", "show", "that", "C0525773#ent", "<e1>", "dose-dependently", "increased", "electrochemical", "signals", "both", "in", "Nacc", "and", "C1418482#ent", "<e2>", "within", "a", "few", "minutes", "of", "injection", "."], "h": {"id": "C0525773", "name": "C0525773#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [14, 15]}}
{"token": ["C0022408#ent", "<e1>", "to", "digestive", "tract", "infections", "have", "been", "well", "studied", "for", "C0036117#ent", "<e2>", ",", "Shigella", ",", "Yersinia", "and", "Campylobacter", "."], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "YB-1", "affinity", "chromatography", "have", "indicated", "that", "in", "addition", "to", "prespliceosome", "factors", "C1417613#ent", "<e1>", "and", "ALY", ",", "YB-1", "binds", "the", "DNA", "repair", "proteins", "C0879290#ent", "<e2>", ",", "DNA", "polymerase", "delta", "Ku80", "and", "WRN", "proteins", "in", "vitro"], "h": {"id": "C1417613", "name": "C1417613#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0879290", "name": "C0879290#ent", "pos": [24, 25]}}
{"token": ["Once", "diagnosed", ",", "C0003216#ent", "<e1>", "abuse", "is", "a", "readily", "reversible", "cause", "of", "hypercalciuria", "and", "C0392525#ent", "<e2>"], "h": {"id": "C0003216", "name": "C0003216#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [14, 15]}}
{"token": ["In", "the", "mouse", "air-pouch", "model", ",", "systemic", "treatment", "the", "C0030956#ent", "<e1>", "produced", "a", "dramatic", "reduction", "in", "C3273763#ent", "<e2>", "leukocyte", "migration", "with", "an", "ID50", "of", "approximately", "40", "micrograms", "per", "mouse", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273763", "name": "C3273763#ent", "pos": [16, 17]}}
{"token": ["Secondly", ",", "we", "studied", "the", "transport", "of", "C0795650#ent", "<e1>", "in", "MDCKII", "C0872351#ent", "<e2>", "transfected", "with", "mouse", "Bcrp1", "or", "human", "MRP2", "."], "h": {"id": "C0795650", "name": "C0795650#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [11, 12]}}
{"token": ["Antibodies", "to", "C1824738#ent", "<e1>", "produced", "to", "verify", "that", "these", "C1564140#ent", "<e2>", "expressed", "."], "h": {"id": "C1824738", "name": "C1824738#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1564140", "name": "C1564140#ent", "pos": [9, 10]}}
{"token": ["Therefore", ",", "we", "examined", "the", "effect", "of", "C1307407#ent", "<e1>", "signaling", "on", "C0156259#ent", "<e2>", "using", "the", "specific", "inhibitor", "for", "C1307407#ent", "<e1>", ",", "rapamycin", "."], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0156259", "name": "C0156259#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "evaluate", "the", "C0002932#ent", "<e1>", "oocyte", "aspiration", "of", "a", "paracervical", "block", "C1418288#ent", "<e2>", ")", "in", "combination", "with", "either", "electro-acupuncture", "(", "EA", ")", "or", "intravenous", "alfentanil", "."], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1418288", "name": "C1418288#ent", "pos": [18, 19]}}
{"token": ["However", "the", "number", "of", "patients", "with", "C3275121#ent", "<e1>", "greater", "in", "the", "group", "with", "C0042584#ent", "<e2>", "on", "ambulatory", "monitoring", "57", "p.", "100", "compared", "with", "13", "p.", "100", ")", "."], "h": {"id": "C3275121", "name": "C3275121#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042584", "name": "C0042584#ent", "pos": [13, 14]}}
{"token": ["C0072354#ent", "<e1>", "PDI", ")", "functions", "as", "an", "C0022202#ent", "<e2>", "to", "catalyze", "thiol", ":", "disulfide", "exchange", "as", "a", "chaperone", "to", "assist", "protein", "folding", "and", "as", "a", "subunit", "of", "prolyl-4-hydroxylase", "and", "microsomal", "triglyceride", "transfer", "protein"], "h": {"id": "C0072354", "name": "C0072354#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0022202", "name": "C0022202#ent", "pos": [7, 8]}}
{"token": ["To", "evaluate", "the", "effectiveness", "of", "cyclophosphamide", "in", "the", "treatment", "of", "C0024143#ent", "<e1>", "we", "designed", "a", "prospective", "study", "patients", "with", "C4053955#ent", "<e2>"], "h": {"id": "C0024143", "name": "C0024143#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C4053955", "name": "C4053955#ent", "pos": [19, 20]}}
{"token": ["We", "investigated", "the", "role", "of", "C0242898#ent", "<e1>", "GABA", ")", "type", "A", "receptors", "in", "the", "C1427627#ent", "<e2>", "of", "the", "newborn", "rat", "parietal", "cortex", "in", "vivo", "in", "vitro"], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1427627", "name": "C1427627#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "type", "IV", "regulate", "C1419283#ent", "<e1>", ",", "but", "the", "downstream", "effects", "differ", "depending", "on", "the", "C1414032#ent", "<e2>", "."], "h": {"id": "C1419283", "name": "C1419283#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414032", "name": "C1414032#ent", "pos": [16, 17]}}
{"token": ["The", "evolutionarily", "conserved", "C0084178#ent", "<e1>", "located", "on", "human", "C1864871#ent", "<e2>", "and", "two", "alleles", "have", "been", "identified", "."], "h": {"id": "C0084178", "name": "C0084178#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1864871", "name": "C1864871#ent", "pos": [8, 9]}}
{"token": ["A", "sample", "of", "52", "adult", "child", "caregivers", "sorted", "25", "C0035222#ent", "<e1>", "with", "caregiving", "tasks", "printed", "on", "them", "into", "different", "C0265034#ent", "<e2>", "based", "on", "the", "similarity", "of", "the", "tasks", "."], "h": {"id": "C0035222", "name": "C0035222#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0265034", "name": "C0265034#ent", "pos": [19, 20]}}
{"token": ["The", "abnormal", "involuntary", "movements", "C0686347#ent", "<e1>", "be", "reduced", "by", "the", "dopamine", "antagonist", "drugs", "C0031436#ent", "<e2>", "and", "butyrophenones", ",", "but", "most", "cause", "an", "increase", "in", "Parkinsonian", "signs", "."], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031436", "name": "C0031436#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "C2987364#ent", "<e1>", "or", "mutant", "ABCG2", "in", "human", "cell", "lines", "resistance", "to", "C0146224#ent", "<e2>", "but", "not", "to", "gimatecan", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0146224", "name": "C0146224#ent", "pos": [13, 14]}}
{"token": ["This", "indicates", "C1705231#ent", "<e1>", "may", "be", "contributing", "to", "drug", "resistance", "C1707163#ent", "<e2>", "patients", ",", "and", "the", "suppression", "of", "C1705231#ent", "<e1>", "function", "could", "be", "a", "new", "strategy", "for", "C1707163#ent", "<e2>", "treatment", "."], "h": {"id": "C1705231", "name": "C1705231#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1707163", "name": "C1707163#ent", "pos": [10, 11]}}
{"token": ["To", "review", "the", "occurrence", "and", "pathophysiology", "of", "C0206157#ent", "<e1>", "associated", "with", "use", "of", "neuromuscular", "blocking", "agents", "C3811197#ent", "<e2>", ")", "and", "systemic", "corticosteroids"], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811197", "name": "C3811197#ent", "pos": [16, 17]}}
{"token": ["To", "study", "activation", "of", "T-lymphocytes", "by", "the", "CD3", "(", "antigen-dependent", ")", "and", "C1367475#ent", "<e1>", ")", "routes", "in", "patients", "with", "systemic", "lupus", "erythematosus", "C0014060#ent", "<e2>", ")", "."], "h": {"id": "C1367475", "name": "C1367475#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [22, 23]}}
{"token": ["Lower", "basal", "C1620185#ent", "<e1>", "mRNA", "levels", "and", "lower", "expression", "of", "C1620185#ent", "<e1>", "and", "Cyp3a11", "mRNAs", "after", "C0000970#ent", "<e1>", "dosing", "were", "also", "observed", "in", "females", "compared", "with", "males", "."], "h": {"id": "C1620185", "name": "C1620185#ent", "pos": [2, 3]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [16, 17]}}
{"token": ["Decrease", "of", "C1704963#ent", "<e1>", "with", "lidocaine", "is", "consistent", "with", "previous", "reports", "of", "similar", "dose-related", "effects", "of", "C0936073#ent", "<e2>", ",", "etomidate", ",", "midazolam", ",", "and", "fentanyl", "on", "C1704963#ent", "<e1>", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1704963", "name": "C1704963#ent", "pos": [2, 3]}}
{"token": ["These", "are", "directly", "related", "to", "the", "primary", "disease", "due", "to", "the", "C0427055#ent", "<e1>", "of", "ankle", "dorsiflexors", "and", "everters", "characteristic", "of", "this", "C0598589#ent", "<e2>"], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0598589", "name": "C0598589#ent", "pos": [21, 22]}}
{"token": ["Antibodies", "raised", "to", "pure", "L1210", "cell", "C1530787#ent", "<e1>", "able", "to", "precipitate", "the", "C1414989#ent", "<e2>", "GAR", "synthetase", "activities", "from", "HeLa", "and", "L1210", "cells", "both", "in", "their", "native", "and", "in", "their", "proteolytically", "shortened", "forms", "."], "h": {"id": "C1530787", "name": "C1530787#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414989", "name": "C1414989#ent", "pos": [12, 13]}}
{"token": ["Local", "C0426575#ent", "<e1>", "such", "as", "nausea", "and", "constipation", ",", "are", "common", "with", "C0042523#ent", "<e2>", "."], "h": {"id": "C0426575", "name": "C0426575#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042523", "name": "C0042523#ent", "pos": [12, 13]}}
{"token": ["Neither", "of", "these", "'", "natural", "retinoids", "augmented", "C3710940#ent", "<e1>", "activity", "in", "a", "HL60", "sub-line", "that", "expresses", "a", "C1366536#ent", "<e2>", "RARalpha", ")", "."], "h": {"id": "C3710940", "name": "C3710940#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [17, 18]}}
{"token": ["Using", "hepatic", "microsomes", "rats", "treated", "with", "C0991617#ent", "<e1>", "that", "induce", "specific", "CYP", "C0022173#ent", "<e2>", ",", "it", "was", "shown", "that", "the", "dexamethasone-inducible", "rat", "isozyme(s", ")", "play", "a", "major", "role", "in", "DFH", "formation", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "the", "C2746050#ent", "<e1>", "5-aza-2'-deoxycytidine", ",", "resulted", "in", "reexpression", "of", "CRBP1", "and", "C1428959#ent", "<e2>", "gene", "expression", "NPC", "cell", "lines"], "h": {"id": "C2746050", "name": "C2746050#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428959", "name": "C1428959#ent", "pos": [13, 14]}}
{"token": ["We", "found", "increased", "TNF-alpha", "and", "C1706006#ent", "<e1>", "immunoreactivity", "in", "lumbar", "spinal", "cord", "sections", "C1704945#ent", "<e2>", "patients", "and", "G93A", "transgenic", "mice"], "h": {"id": "C1706006", "name": "C1706006#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [13, 14]}}
{"token": ["A", "pre-existing", "pathologic", "factor", "found", "in", "two", "cases", "(", "one", "child", "with", "C3495559#ent", "<e1>", "treated", "by", "corticoids", "and", "one", "child", "with", "C1537501#ent", "<e2>", "and", "Van", "Beuren's", "syndrome", "."], "h": {"id": "C3495559", "name": "C3495559#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [21, 22]}}
{"token": ["As", "thrombin", "receptors", "focal", "adhesion", "kinase", "FAK", ")", "potently", ",", "we", "explored", "whether", "this", "C0812329#ent", "<e1>", "in", "the", "activation", "of", "Rho", "by", "C3812695#ent", "<e2>", "."], "h": {"id": "C0812329", "name": "C0812329#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3812695", "name": "C3812695#ent", "pos": [22, 23]}}
{"token": ["Rad51", "and", "RecA", "share", "a", "core", "ATPase", "domain", "is", "structurally", "similar", "to", "the", "ATPase", "domains", "C0084378#ent", "<e1>", "and", "the", "C0001473#ent", "<e2>"], "h": {"id": "C0084378", "name": "C0084378#ent", "pos": [15, 16]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [19, 20]}}
{"token": ["C0162714#ent", "<e1>", "PR", ")", "is", "a", "prime", "target", "for", "rational", "C0376565#ent", "<e2>"], "h": {"id": "C0162714", "name": "C0162714#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0376565", "name": "C0376565#ent", "pos": [10, 11]}}
{"token": ["Three", "C0040615#ent", "<e1>", "produced", "dose-dependent", "antagonism", "of", "the", "behavioral", "effects", "of", "C0031381#ent", "<e2>", "administration", "."], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [11, 12]}}
{"token": ["A", "sensitive", "immunoassay", "system", "a", "specific", "monoclonal", "antibody", "C0023816#ent", "<e1>", "C1416902#ent", "<e2>", ")", "recently", "demonstrated", "the", "presence", "of", "an", "C1416902#ent", "<e2>", "mass", "in", "preheparin", "serum", "."], "h": {"id": "C0023816", "name": "C0023816#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1416902", "name": "C1416902#ent", "pos": [10, 11]}}
{"token": ["An", "C0022173#ent", "<e1>", "of", "alpha-D-mannosidase", "and", "beta-D-mannosidase", "was", "identified", "in", "control", "and", "C2930997#ent", "<e2>", "sera", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2930997", "name": "C2930997#ent", "pos": [12, 13]}}
{"token": ["Although", "sleep", "disturbances", "common", "in", "C0014547#ent", "<e1>", ",", "few", "studies", "examined", "the", "prevalence", "and", "impact", "of", "C0037317#ent", "<e2>", "C0014547#ent", "<e1>", "patients", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037317", "name": "C0037317#ent", "pos": [16, 17]}}
{"token": ["Topical", "administration", "1", "%", "epinephrine", "to", "C0235267#ent", "<e1>", "injected", "with", "C0085196#ent", "<e2>", "resulted", "in", "a", "mean", "fall", "of", "IOP", "of", "40", "%", "that", "persisted", "for", "as", "long", "as", "three", "months", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085196", "name": "C0085196#ent", "pos": [10, 11]}}
{"token": ["A", "200-patient", "phase", "III", "trial", "testing", "C3827184#ent", "<e1>", "in", "children", "with", "severe", "C0025306#ent", "<e2>", ",", "is", "being", "carried", "out", "in", "the", "UK", "and", "North", "America"], "h": {"id": "C3827184", "name": "C3827184#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025306", "name": "C0025306#ent", "pos": [12, 13]}}
{"token": ["A", "comparison", "of", "clofazimine", "and", "C1639494#ent", "<e1>", "in", "the", "management", "of", "untreated", "C0023348#ent", "<e2>", "no", "significant", "differences", "between", "the", "two", "drugs", "in", "terms", "of", "morphological", "and", "bacterial", "indices", "."], "h": {"id": "C1639494", "name": "C1639494#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0023348", "name": "C0023348#ent", "pos": [12, 13]}}
{"token": ["Chemical", "modification", "the", "enzyme", "showed", "that", "C1366526#ent", "<e1>", "was", "rapidly", "inactivated", "by", "His", ",", "Cys", ",", "C1705940#ent", "<e2>", "and", "Lys-specific", "reagents", "."], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705940", "name": "C1705940#ent", "pos": [16, 17]}}
{"token": ["The", "beneficial", "effects", "of", "C0242893#ent", "<e1>", "beta", "25", "35-induced", "amnesia", "was", "examined", "using", "the", "cholinesterase", "inhibitor", "tacrine", "C0039245#ent", "<e2>", ",", "1.3", "and", "4.3", "mumol/kg", "i.p", ".", ")"], "h": {"id": "C0242893", "name": "C0242893#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039245", "name": "C0039245#ent", "pos": [17, 18]}}
{"token": ["We", "report", "on", "a", "29-year-old", "severely", "compromised", "acquired", "immunodeficiency", "syndrome", "patient", "who", "developed", "C0085582#ent", "<e1>", "weeks", "after", "an", "episode", "of", "C0017409#ent", "<e2>"], "h": {"id": "C0085582", "name": "C0085582#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017409", "name": "C0017409#ent", "pos": [20, 21]}}
{"token": ["A", "study", "of", "the", "distribution", "of", "pyrrolidone", "carboxylyl", "peptidase", "PCP", ")", "activity", "among", "cell", "fractions", "Streptococcus", "cremoris", "C1704665#ent", "<e1>", "revealed", "that", "this", "C0027203#ent", "<e2>", "is", "associated", "with", "particulate", "fraction", ",", "which", "mainly", "consists", "of", "membrane", "material"], "h": {"id": "C1704665", "name": "C1704665#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [22, 23]}}
{"token": ["beta-adrenergic", "hyporesponsiveness", "in", "many", "C0878544#ent", "<e1>", "is", "linked", "to", "expression", "of", "C1533698#ent", "<e2>", "iNOS", ")", "and", "increased", "production", "of", "NO", "."], "h": {"id": "C0878544", "name": "C0878544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [11, 12]}}
{"token": ["The", "introduction", "of", "a", "nitro-group", "at", "the", "4-position", "of", "C1161334#ent", "<e1>", "not", "alter", "remarkably", "the", "metabolic", "pattern", "of", "C0053225#ent", "<e2>", "the", "fruit", "bat"], "h": {"id": "C1161334", "name": "C1161334#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0053225", "name": "C0053225#ent", "pos": [18, 19]}}
{"token": ["Late", "stages", "the", "disease", "were", "characterized", "by", "C0554309#ent", "<e1>", "and", "chronic", "renal", "interstitial", "inflammatory", "infiltrates", "all", "affected", "animals", "and", "C1290398#ent", "<e2>", "a", "few", "."], "h": {"id": "C0554309", "name": "C0554309#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1290398", "name": "C1290398#ent", "pos": [19, 20]}}
{"token": ["C0000975#ent", "<e1>", "inducibility", "of", "the", "hybrid", "promoter", "dependent", "on", "the", "C2828027#ent", "<e2>", "demonstrating", "that", "a", "facB-dependent", "upstream", "activating", "sequence", "(", "UAS", ")", "for", "acetate", "must", "be", "located", "in", "the", "208", "bp", "acuD", "fragment"], "h": {"id": "C0000975", "name": "C0000975#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2828027", "name": "C2828027#ent", "pos": [10, 11]}}
{"token": ["In", "this", "report", ",", "we", "show", "that", "C3494506#ent", "<e1>", "stimulates", "both", "tyrosine", "phosphorylation", "Pyk2", "and", "C0752312#ent", "<e2>", "activation", "in", "a", "transient", "and", "dose-dependent", "manner", "in", "rat", "aortic", "smooth", "muscle", "cells"], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [15, 16]}}
{"token": ["In", "view", "of", "its", "crucial", "role", "in", "the", "development", "of", "C3540579#ent", "<e1>", "immune", "responses", "we", "studied", "the", "expression", "of", "IL-12", "C1826761#ent", "<e2>", "in", "the", "CNS", "and", "lymphoid", "organs", "mice", "with", "EAE", "."], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1826761", "name": "C1826761#ent", "pos": [20, 21]}}
{"token": ["An", "autopsy", "case", "of", "a", "65-year-old", "male", "who", "died", "of", "hepatocellular", "carcinoma", "on", "C0023890#ent", "<e1>", "complicated", "with", "C0036203#ent", "<e2>", "presented", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0036203", "name": "C0036203#ent", "pos": [17, 18]}}
{"token": ["In", "17", "patients", "with", "C1847493#ent", "<e1>", "influence", "of", "intra-veinously", "applicated", "C0004969#ent", "<e2>", "(", "Fludilat", ")", "on", "cardiac", "output", "central-hemodynamic", "parameter", "has", "been", "investigated", "."], "h": {"id": "C1847493", "name": "C1847493#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0004969", "name": "C0004969#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "we", "demonstrated", "that", "the", "presence", "of", "the", "C1854520#ent", "<e1>", "alone", "is", "sufficient", "to", "direct", "expression", "of", "a", "C1334435#ent", "<e2>", "suggesting", "that", "hStaf/ZNF143", "can", "recruit", "per", "se", "the", "transcription", "machinery"], "h": {"id": "C1854520", "name": "C1854520#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334435", "name": "C1334435#ent", "pos": [19, 20]}}
{"token": ["C0039483#ent", "<e1>", "GCA", ")", "and", "C0032533#ent", "<e2>", "PMR", ")", "are", "closely", "related", "disorders", "found", "in", "older", "patients", "and", "vasculitis", "has", "been", "proposed", "as", "a", "part", "of", "the", "pathogenesis", "of", "PMR", "."], "h": {"id": "C0039483", "name": "C0039483#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0032533", "name": "C0032533#ent", "pos": [5, 6]}}
{"token": ["The", "expression", "of", "C4255327#ent", "<e1>", "TFF1", "and", "TFF2", ")", "and", "mucins", "(", "C1705281#ent", "<e2>", ",", "MUC2", ",", "MUC5AC", ",", "and", "MUC6", ")", "has", "previously", "been", "described", "in", "gastric", "polyps"], "h": {"id": "C4255327", "name": "C4255327#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [12, 13]}}
{"token": ["Because", "1,3-butanediol", "does", "not", "stimulate", "increases", "of", "insulin", "in", "plasma", ",", "it", "may", "be", "more", "desirable", "than", "C0077025#ent", "<e1>", "for", "inducing", "metabolic", "changes", "characteristic", "of", "C0022638#ent", "<e2>"], "h": {"id": "C0077025", "name": "C0077025#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0022638", "name": "C0022638#ent", "pos": [25, 26]}}
{"token": ["Both", "ST", "and", "C1420066#ent", "<e1>", "resulted", "in", "decreased", "type", "I", "increased", "C1417537#ent", "<e2>", "as", "well", "as", "de", "novo", "expression", "of", "IIb", "MHC"], "h": {"id": "C1420066", "name": "C1420066#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417537", "name": "C1417537#ent", "pos": [11, 12]}}
{"token": ["These", "results", "suggest", "that", "sphingoid", "bases", "inhibit", "C1414402#ent", "<e1>", "activity", "without", "altering", "C0031671#ent", "<e2>", "activation", "and", "that", "they", "exhibit", "a", "similar", "structure-activity", "relationship", "for", "both", "C1414402#ent", "<e1>", "and", "PKC", "."], "h": {"id": "C1414402", "name": "C1414402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [12, 13]}}
{"token": ["CYP1A1", "modulation", "was", "abolished", "by", "a", "cotreatment", "with", "resveratrol", ",", "an", "established", "AhR", "antagonist", "arguing", "for", "C1706481#ent", "<e1>", "activation", "by", "C0755562#ent", "<e2>", "."], "h": {"id": "C1706481", "name": "C1706481#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0755562", "name": "C0755562#ent", "pos": [20, 21]}}
{"token": ["Amplitude", "of", "the", "primary", "cortical", "SEP", "N20", "was", "found", "to", "be", "unchanged", "after", "thiopentone", "and", "to", "be", "increased", "after", "C0015131#ent", "<e1>", ",", "indicating", "the", "synchronizing", "properties", "of", "this", "C1254351#ent", "<e2>", "."], "h": {"id": "C0015131", "name": "C0015131#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [28, 29]}}
{"token": ["The", "idiopathic", "inflammatory", "myopathies", "IIM", ")", "of", "childhood", "are", "rare", ",", "C0004364#ent", "<e1>", "of", "which", "the", "most", "common", "is", "juvenile", "dermatomyositis", "C0263666#ent", "<e2>", ")", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0263666", "name": "C0263666#ent", "pos": [21, 22]}}
{"token": ["It", "has", "moderate", "affinity", "for", "the", "C1366500#ent", "<e1>", "significant", "antiproliferative", "and", "C0002842#ent", "<e2>", "and", "produces", "secretory", "transformation", "the", "endometrium", "."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [11, 12]}}
{"token": ["Onset", "to", "first", "seizure", ",", "first", "seizure", "C2926735#ent", "<e1>", ",", "seizure", "frequency", "total", "duration", "of", "C0036572#ent", "<e2>", "were", "determined", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [15, 16]}}
{"token": ["In", "order", "to", "determine", "the", "natural", "history", "this", "disorder", ",", "the", "outcome", "of", "12", "infants", "with", "neonatal", "C0019158#ent", "<e1>", "secondary", "to", "C0020635#ent", "<e2>", "is", "reviewed", "."], "h": {"id": "C0019158", "name": "C0019158#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020635", "name": "C0020635#ent", "pos": [21, 22]}}
{"token": ["Factors", "that", "predispose", "pediatric", "patients", "to", "the", "development", "of", "C0039007#ent", "<e1>", "include", "very", "young", "age", ",", "diabetes", "mellitus", "an", "immunocompromised", "state", "and", "C0027726#ent", "<e2>"], "h": {"id": "C0039007", "name": "C0039007#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [22, 23]}}
{"token": ["Two", "C0010531#ent", "<e1>", "isolated", "from", "rabbit", "liver", "extracts", "C0007332#ent", "<e2>", "far", "more", "effectively", "than", "histones", "."], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0007332", "name": "C0007332#ent", "pos": [8, 9]}}
{"token": ["Treatments", "with", "UtSMCs", "CM", "to", "C1425042#ent", "<e1>", "and", "RL95", "cells", "stimulated", "C0164786#ent", "<e2>", "phosphorylation", "in", "a", "time-dependent", "manner", "."], "h": {"id": "C1425042", "name": "C1425042#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0164786", "name": "C0164786#ent", "pos": [11, 12]}}
{"token": ["These", "isozymes", "play", "a", "crucial", "role", "in", "the", "developing", "of", "the", "inflammatory", "cascade", "and", "in", "the", "C1414672#ent", "<e1>", "of", "various", "C0127400#ent", "<e2>", "released", "from", "tissue", "injury"], "h": {"id": "C1414672", "name": "C1414672#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [20, 21]}}
{"token": ["Special", "emphasis", "placed", "on", "C0016667#ent", "<e1>", "representative", "of", "a", "newly-discovered", "class", "of", "C0019247#ent", "<e2>", "by", "an", "unstable", "trinucleotide", "repeat"], "h": {"id": "C0016667", "name": "C0016667#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [12, 13]}}
{"token": ["It", "is", "well", "recognized", "that", "adenoid", "hypertrophy", "C2607914#ent", "<e1>", "common", "in", "children", "and", "that", "recurrent", "C0581381#ent", "<e2>", "a", "fact", "of", "life", "."], "h": {"id": "C2607914", "name": "C2607914#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0581381", "name": "C0581381#ent", "pos": [15, 16]}}
{"token": ["Clenbuterol", "(", "C", ")", ",", "a", "long-acting", "beta", "2-selective", "bronchodilator", "was", "compared", "with", "C0543495#ent", "<e1>", "(", "S", ")", "in", "C0004099#ent", "<e2>", "EIA", ")", "at", "two", "premedication", "time", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [13, 14]}, "relation": "may_prevent", "t": {"id": "C0004099", "name": "C0004099#ent", "pos": [19, 20]}}
{"token": ["According", "to", "several", "studies", ",", "green", "tea", "individual", "C0059438#ent", "<e1>", "can", "inhibit", "the", "induction", "of", "C0029282#ent", "<e2>", "ODC", ")", ",", "the", "key", "enzyme", "in", "the", "biosynthesis", "of", "polyamines", "."], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0029282", "name": "C0029282#ent", "pos": [15, 16]}}
{"token": ["Ym1/2", "expression", "was", "completely", "inhibited", "by", "C0011777#ent", "<e1>", "(", "Dex", ")", "in", "C1332077#ent", "<e2>", "and", "weakly", "inhibited", "in", "the", "lung", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332077", "name": "C1332077#ent", "pos": [12, 13]}}
{"token": ["The", "normal", "anion", "C2984553#ent", "<e1>", "could", "be", "explained", "by", "normophosphatemia", "or", "C0085681#ent", "<e2>", "even", "in", "the", "patients", "with", "advanced", "renal", "failure"], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085681", "name": "C0085681#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "do", "not", "support", "the", "concept", "that", "C0267370#ent", "<e1>", "occurs", "principally", "in", "combination", "with", "C0003507#ent", "<e2>"], "h": {"id": "C0267370", "name": "C0267370#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003507", "name": "C0003507#ent", "pos": [15, 16]}}
{"token": ["It", "is", "shown", "that", "C0010592#ent", "<e1>", "A", "inhibited", "C0055530#ent", "<e2>", "of", "bile", "acid", "intermediates", ",", "depending", "on", "their", "polarity", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0055530", "name": "C0055530#ent", "pos": [8, 9]}}
{"token": ["C1332791#ent", "<e1>", "GM-CSF", ")", "showed", "a", "capacity", "for", "up-regulation", "of", "C1366561#ent", "<e2>", "and", "CD86", "expression", "on", "monocytes", ",", "of", "a", "magnitude", "that", "was", "similar", "both", "in", "patients", "with", "SLE", "and", "in", "normal", "subjects"], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366561", "name": "C1366561#ent", "pos": [10, 11]}}
{"token": ["These", "results", "show", "that", "C2975867#ent", "<e1>", "specifically", "regulates", "the", "C1417099#ent", "<e2>", "activity", "required", "for", "anterior", "formation", "in", "Xenopus", "development"], "h": {"id": "C2975867", "name": "C2975867#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417099", "name": "C1417099#ent", "pos": [9, 10]}}
{"token": ["To", "determine", "the", "effect", "of", "expression", "of", "C1417574#ent", "<e1>", "on", "C1367721#ent", "<e2>", "responsiveness", ",", "DD-1", "cells", "were", "cotransfected", "with", "a", "C1417574#ent", "<e1>", "expression", "vector", "with", "pRSVneo", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [7, 8]}}
{"token": ["When", "patients", "requiring", "tracheal", "intubation", "with", "potential", "contraindications", "to", "succinylcholine", "use", ",", "the", "emergency", "physician", "need", "to", "substitute", "a", "C2985520#ent", "<e1>", "nondepolarizing", "neuromuscular", "blocking", "agent", "such", "as", "rocuronium", "or", "C0066621#ent", "<e2>", "."], "h": {"id": "C2985520", "name": "C2985520#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0066621", "name": "C0066621#ent", "pos": [29, 30]}}
{"token": ["We", "observed", "that", "the", "N-SH3", "and", "C-SH3", "domains", "C1333707#ent", "<e1>", "fusion", "proteins", "coprecipitated", "with", "C1414120#ent", "<e2>", "Sos1", "."], "h": {"id": "C1333707", "name": "C1333707#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrate", "that", "Tctex-1", "and", "C1417031#ent", "<e1>", "compete", "for", "binding", "to", "C1425753#ent", "<e2>", "that", "overexpressed", "C1417031#ent", "<e1>", "displaces", "endogenous", "Tctex-1", "from", "dynein", "complexes", "MDCK", "cells"], "h": {"id": "C1417031", "name": "C1417031#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1425753", "name": "C1425753#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", "C1167732#ent", "<e1>", "must", "be", "considered", "a", "systemic", "complication", "inflammatory", "bowel", "disease", "C0022104#ent", "<e2>", ")", "if", "adverse", "reaction", "5-ASA", "and", "sulfasalazine", "as", "well", "as", "other", "possible", "pathogenetic", "factors", "been", "ruled", "out", "."], "h": {"id": "C1167732", "name": "C1167732#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [13, 14]}}
{"token": ["Data", "obtained", "indicate", "that", "the", "lipase", "and", "the", "C0054741#ent", "<e1>", "are", "identical", "and", "coded", "for", "by", "the", "same", "C0079429#ent", "<e2>", "."], "h": {"id": "C0054741", "name": "C0054741#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [18, 19]}}
{"token": ["These", "drugs", "include", ":", "the", "C0242948#ent", "<e1>", "e.g.", "levamisole", ",", "the", "C0242898#ent", "<e2>", "piperazine", ",", "and", "the", "avermectins", "which", "open", "Cl-", "channels", "."], "h": {"id": "C0242948", "name": "C0242948#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242898", "name": "C0242898#ent", "pos": [11, 12]}}
{"token": ["As", "to", "the", "sensitivity", "of", "the", "test", ",", "two", "\"", "false", "negatives", "were", "obtained", ":", "the", "C0009079#ent", "<e1>", "the", "antidepressant", "C0025912#ent", "<e2>", "."], "h": {"id": "C0009079", "name": "C0009079#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0025912", "name": "C0025912#ent", "pos": [20, 21]}}
{"token": ["Probabilities", "of", "atrial", "or", "ventricular", "emboli", "similar", "to", "the", "other", "dilated", "cardiomyopathies", "C0018801#ent", "<e1>", "are", "treated", "accordingly", ",", "i.e.", ",", "with", "C0265374#ent", "<e2>", "or", "enoxaparin", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0265374", "name": "C0265374#ent", "pos": [21, 22]}}
{"token": ["He", "was", "diagnosed", "with", "C0023885#ent", "<e1>", "sepsis", ",", "acute", "renal", "failure", "and", "C0012739#ent", "<e2>", "and", "received", "intensive", "care", "but", "died", "on", "April", "1", "."], "h": {"id": "C0023885", "name": "C0023885#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012739", "name": "C0012739#ent", "pos": [12, 13]}}
{"token": ["The", "inhibitory", "effect", "of", "cGMP", "on", "C0388638#ent", "<e1>", "could", "be", "reversed", "by", "N-(2-[methylamino]ethyl)-5-isoquinolinesulfonamide", ",", "a", "C0001645#ent", "<e2>", "of", "cGMP-dependent", "protein", "kinase"], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [15, 16]}}
{"token": ["Altered", "C0033679#ent", "<e1>", "TG2", ")", "expression", "is", "associated", "with", "development", "of", "many", "C1290884#ent", "<e2>"], "h": {"id": "C0033679", "name": "C0033679#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [12, 13]}}
{"token": ["Whereas", "C0017953#ent", "<e1>", "no", "effect", "the", "macrolide", "erythromycin", "several", "C0002556#ent", "<e2>", "reduced", "and", "fluoroquinolones", "slightly", "stimulated", "hla", "expression", "."], "h": {"id": "C0017953", "name": "C0017953#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002556", "name": "C0002556#ent", "pos": [9, 10]}}
{"token": ["Dipiperidinoethane", "(", "C0058415#ent", "<e1>", ")", "administration", "produces", "C0751495#ent", "<e2>", "and", "CNS", "lesions", "."], "h": {"id": "C0058415", "name": "C0058415#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [7, 8]}}
{"token": ["Three", "mammalian", "hedgehog", "genes", "sonic", "hedgehog", "C0672708#ent", "<e1>", ")", ",", "indian", "hedgehog", "Ihh", ")", ",", "and", "desert", "hedgehog", "C1414044#ent", "<e2>", ")", "have", "been", "identified", "."], "h": {"id": "C0672708", "name": "C0672708#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414044", "name": "C1414044#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", ",", "we", "analyzed", "collagen", "and", "C0962754#ent", "<e1>", "expression", "in", "dermal", "fibroblasts", "from", "eight", "patients", "with", "C1290138#ent", "<e2>", "compared", "the", "findings", "with", "those", "from", "nine", "sex-", "and", "age-matched", "healthy", "subjects"], "h": {"id": "C0962754", "name": "C0962754#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [18, 19]}}
{"token": ["Therefore", ",", "using", "the", "kinase", "inhibitors", "C0109289#ent", "<e1>", "genistein", ",", "we", "showed", "that", "PKC", "and", "C1705341#ent", "<e2>", "activities", ",", "respectively", ",", "participated", "in", "TGF-beta1-", "and", "BMP-2-induced", "increases", "in", "junB", "mRNA", "levels", "."], "h": {"id": "C0109289", "name": "C0109289#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [15, 16]}}
{"token": ["Seven", "had", "antegrade", "cardioplegia", "C0010575#ent", "<e1>", ")", "alone", ",", "while", "seven", "had", "C0010575#ent", "<e1>", "until", "arrest", ",", "then", "C1419325#ent", "<e1>", "."], "h": {"id": "C0010575", "name": "C0010575#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419325", "name": "C1419325#ent", "pos": [18, 19]}}
{"token": ["The", "authors", "describe", "the", "case", "of", "a", "70-year-old", "male", "who", "developed", "a", "peculiar", "C1848862#ent", "<e1>", "characterized", "by", "pathological", "gambling", "PG", ")", ",", "delusional", "parasitosis", "adipsia", "with", "C1457887#ent", "<e2>"], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [26, 27]}}
{"token": ["For", "example", ",", "while", "Ig", "alpha", "src-family", "kinases", "the", "C0134982#ent", "<e1>", "binds", "Shc", "avidly", ",", "CD3", "epsilon", "C1335892#ent", "<e2>", "over", "src-kinases", "and", "does", "not", "bind", "Shc", "."], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [17, 18]}}
{"token": ["Although", "SB239063", "and", "SP600125", "significantly", "reversed", "glutamate", "uptake", "inhibition", "and", "ammonia-induced", "decline", "in", "glutamate-aspartate", "transporter", "protein", "levels", "C0755562#ent", "<e1>", "did", "not", ",", "indicating", "a", "differential", "effect", "these", "C0010536#ent", "<e2>", "in", "ammonia-induced", "astrocyte", "swelling", "and", "glutamate", "transport", "impairment"], "h": {"id": "C0755562", "name": "C0755562#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010536", "name": "C0010536#ent", "pos": [27, 28]}}
{"token": ["We", "show", "by", "gene", "expression", "analysis", "C1413430#ent", "<e1>", "acts", "upstream", "of", "Nodal", ",", "Lefty2", "and", "C1418596#ent", "<e2>", "in", "the", "lateral", "mesoderm", "and", "of", "Lefty1", "in", "the", "presumptive", "floor", "plate", "."], "h": {"id": "C1413430", "name": "C1413430#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1418596", "name": "C1418596#ent", "pos": [15, 16]}}
{"token": ["Cysteine", ",", "at", "all", "concentrations", "tested", ",", "did", "not", "protect", "the", "inhibitory", "effect", "of", "1", "and", "4", "mM", "DMPS", "and", "C0012384#ent", "<e1>", ",", "but", "protected", "1", "mM", "C1538586#ent", "<e2>", "inhibition", "."], "h": {"id": "C0012384", "name": "C0012384#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1538586", "name": "C1538586#ent", "pos": [27, 28]}}
{"token": ["The", "effects", "of", "dithiol", "chelating", "agents", "meso-2,3-dimercaptosuccinic", "acid", "C0012384#ent", "<e1>", ")", ",", "2,3-dimercaptopropane-1-sulfonic", "acid", "DMPS", ")", ",", "and", "2,3-dimercaptopropanol", "(", "C1538586#ent", "<e2>", ")", "on", "delta-aminolevulinate", "dehydratase", "delta-ALA-D", ")", "from", "human", "erythrocytes", "were", "evaluated", "."], "h": {"id": "C0012384", "name": "C0012384#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1538586", "name": "C1538586#ent", "pos": [20, 21]}}
{"token": ["Homologous", "sequences", "C3539530#ent", "<e1>", "comparison", "indicated", "that", "the", "similarities", "among", "the", "C1417679#ent", "<e2>", "at", "nucleotide", "and", "amino", "acid", "levels", "were", "over", "87", "%", "and", "90", "%", ",", "respectively", "."], "h": {"id": "C3539530", "name": "C3539530#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["An", "C3812173#ent", "<e1>", "ara-CTP", "was", "extracted", "from", "blastic", "cells", "ara-C", "treatment", "with", "C0600203#ent", "<e2>", "final", "concentration", ",", "0.3", "M", ")", "neutralized", "with", "an", "equal", "volume", "of", "cold", "freon", "containing", "0.5", "M", "tri-n-octylamine", "."], "h": {"id": "C3812173", "name": "C3812173#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0600203", "name": "C0600203#ent", "pos": [12, 13]}}
{"token": ["Two", "genes", "for", "virus-associated", "VA", "RNAs", "in", "the", "human", "adenovirus", "type", "7", "Ad7", ")", "genome", "are", "compared", "to", "Ad2", ",", "Ad4", ",", "C1865868#ent", "<e1>", ",", "simian", "VA", "RNAs", ",", "and", "C0012890#ent", "<e2>", "transcripts", "of", "Epstein-Barr", "virus"], "h": {"id": "C1865868", "name": "C1865868#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0012890", "name": "C0012890#ent", "pos": [30, 31]}}
{"token": ["This", "study", "evaluates", "the", "value", "of", "contrast-enhanced", "pulse-inversion", "harmonic", "imaging", "(", "PIHI", ")", "to", "detect", "synovial", "vascularization", "thus", "the", "therapeutic", "effects", "C0032950#ent", "<e1>", "treatment", "on", "the", "inflammation", "in", "finger", "joints", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C0032950", "name": "C0032950#ent", "pos": [21, 22]}, "relation": "may_prevent", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [32, 33]}}
{"token": ["The", "important", "clinical", "features", "were", "C0751837#ent", "<e1>", "poor", "coordination", "hands", ",", "intention", "tremors", "exaggerated", "deep", "tendon", "reflexes", "C0234133#ent", "<e2>", "extensor", "plantar", "."], "h": {"id": "C0751837", "name": "C0751837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0234133", "name": "C0234133#ent", "pos": [17, 18]}}
{"token": ["We", "propose", "that", "C0031727#ent", "<e1>", "and", "phosphatase", "anchoring", "at", "the", "NE", "by", "C1412311#ent", "<e2>", "plays", "in", "a", "role", "in", "modulating", "nuclear", "reassembly", "the", "end", "of", "mitosis", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412311", "name": "C1412311#ent", "pos": [12, 13]}}
{"token": ["High", "titer", "autoantibodies", "Aabs", ")", "toward", "intracellular", "C3541394#ent", "<e1>", "are", "a", "hallmark", "for", "C0085859#ent", "<e2>", "and", "serve", "as", "diagnostic", "markers", "predictors", "for", "disease", "manifestations"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0085859", "name": "C0085859#ent", "pos": [13, 14]}}
{"token": ["C2697656#ent", "<e1>", "fractions", "released", "by", "NHS", "or", "C0012695#ent", "<e2>", "appeared", "to", "a", "large", "degree", "to", "overlap", ",", "suggesting", "that", "NHS-mediated", "C2697656#ent", "<e1>", "release", "may", "involve", "the", "action", "of", "a", "serum", "chelator"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [7, 8]}}
{"token": ["C1839264#ent", "<e1>", "shows", "mutations", "in", "one", "of", "the", "major", "myelin", "proteins", "the", "C1418655#ent", "<e2>", "PLP", ")", "gene", ",", "and", "is", "allelic", "to", "Pelizaeus-Merzbacher", "disease"], "h": {"id": "C1839264", "name": "C1839264#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418655", "name": "C1418655#ent", "pos": [12, 13]}}
{"token": ["We", "conclude", "that", "the", "careful", "administration", "of", "small", "doses", "C0286651#ent", "<e1>", "in", "patients", "with", "mixed", "dyslipidemia", "C1449704#ent", "<e2>", "is", "associated", "with", "significant", "amelioration", "of", "lipid", "abnormalities"], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1449704", "name": "C1449704#ent", "pos": [16, 17]}}
{"token": ["C0165603#ent", "<e1>", "is", "a", "C0003416#ent", "<e2>", "a", "novel", "mechanism", "of", "action", ",", "via", "inhibition", "of", "parasite", "mitochondrial", "electron", "transport", "and", "a", "favorable", "safety", "profile", "."], "h": {"id": "C0165603", "name": "C0165603#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003416", "name": "C0003416#ent", "pos": [4, 5]}}
{"token": ["Although", "the", "pathophysiology", "of", "C1413821#ent", "<e1>", "cystatin", "C", "atherosclerosis", "and", "diabetes", "requires", "further", "investigation", ",", "increased", "serum", "C1413821#ent", "<e1>", "serve", "as", "a", "biomarker", "for", "both", "C0012634#ent", "<e1>", "."], "h": {"id": "C1413821", "name": "C1413821#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [25, 26]}}
{"token": ["C0035339#ent", "<e1>", "such", "as", "C0165631#ent", "<e2>", "tazarotene", "cream", "are", "considered", "first-line", "therapy", "the", "treatment", "of", "acne", "vulgaris"], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0165631", "name": "C0165631#ent", "pos": [4, 5]}}
{"token": ["The", "C0669365#ent", "<e1>", "AGBM", "surfaces", "were", "smooth", "in", "stages", "I", "C3273406#ent", "<e2>", "MGN", ",", "but", "in", "stage", "III", "MGN", "endothelial", "surfaces", "irregular", "and", "perforated", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [10, 11]}}
{"token": ["Multivariable", "predictors", "development", "of", "DSWI", "were", "old", "age", "C0011847#ent", "<e1>", ",", "previous", "stroke", "or", "TIA", ",", "and", "C0018802#ent", "<e2>"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [17, 18]}}
{"token": ["A", "healthy", "21-year-old", "man", "receiving", "C0027396#ent", "<e1>", "for", "muscle", "spasm", "admitted", "with", "chief", "complaint", "severe", "C0018681#ent", "<e2>", "."], "h": {"id": "C0027396", "name": "C0027396#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [15, 16]}}
{"token": ["Injections", "of", "strychnine", "(", "C1516869#ent", "<e1>", "n", "=", "5", ")", "or", "phaclofen", "(", "C2936801#ent", "<e2>", "n", "=", "2", ")", "into", "RVLM", "were", "without", "effect", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2936801", "name": "C2936801#ent", "pos": [13, 14]}}
{"token": ["Consistent", "with", "findings", ",", "substitution", "of", "the", "amino-terminal", ",", "cytoplasmic", "loop", "or", "C1416810#ent", "<e1>", "into", "GLUT1", "backbone", "did", "not", "recapitulate", "normal", "C2982484#ent", "<e2>", "trafficking", "."], "h": {"id": "C1416810", "name": "C1416810#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [21, 22]}}
{"token": ["In", "some", "individuals", ",", "concentration", "of", "C1420002#ent", "<e1>", "optimal", "for", "IgG", "and", "C1706005#ent", "<e2>", "secretion", "inhibited", "IgA", "production", "."], "h": {"id": "C1420002", "name": "C1420002#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [12, 13]}}
{"token": ["These", "744", "C1875400#ent", "<e1>", "were", "identified", "by", "means", "of", "the", "AUTO-MICROBIC-SYSTEM", "(", "C1860224#ent", "<e2>", ")", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1860224", "name": "C1860224#ent", "pos": [12, 13]}}
{"token": ["31", "critically", "ill", "patients", "(", "mean", "age", "+", "/-", "3", "years", ")", "entered", "the", "clinical", "study", "23", "subjects", "were", "on", "artificial", "ventilation", "15", "acquired", "C0243026#ent", "<e1>", ",", "9", "renal", "insufficiency", "and", "7", "acute", "or", "C2936476#ent", "<e2>"], "h": {"id": "C0243026", "name": "C0243026#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C2936476", "name": "C2936476#ent", "pos": [34, 35]}}
{"token": ["By", "contrast", ",", "C1413291#ent", "<e1>", "selectively", "binds", "unsumoylated", "C1704851#ent", "<e2>", "mutants", "."], "h": {"id": "C1413291", "name": "C1413291#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704851", "name": "C1704851#ent", "pos": [8, 9]}}
{"token": ["The", "marked", "difference", "between", "pulmonary", "gas", "trapping", "and", "Evans'", "blue", "responses", "suggest", "that", "[Sar9,Met(O2)11]-SP-induced", "C0001883#ent", "<e1>", "not", "secondary", "to", "increased", "C0034063#ent", "<e2>"], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [20, 21]}}
{"token": ["Four", "cases", "are", "presented", "of", "spontaneously", "breathing", "patients", "who", "sustained", "C0001883#ent", "<e1>", "from", "one", "to", "several", "hours", ",", "leading", "to", "manifest", "C0034063#ent", "<e2>"], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0034063", "name": "C0034063#ent", "pos": [21, 22]}}
{"token": ["C0023522#ent", "<e1>", "a", "well", "know", "side", "effect", "C1417487#ent", "<e2>", ",", "especially", "in", "conjunction", "with", "intrathecal", "administration", "whole", "brain", "radio", "therapy"], "h": {"id": "C0023522", "name": "C0023522#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [7, 8]}}
{"token": ["Only", "the", "synthetic", "homolog", "C0068333#ent", "<e1>", ",", "has", "been", "approved", "for", "use", "to", "C0027497#ent", "<e2>", "vomiting", "associated", "with", "cancer", "chemotherapy.(ABSTRACT", "TRUNCATED", "AT", "400", "WORDS", ")"], "h": {"id": "C0068333", "name": "C0068333#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0027497", "name": "C0027497#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "we", "proposed", "that", "C1333924#ent", "<e1>", "was", "involved", "in", "C0082529#ent", "<e2>", "PLD2", "expression", "."], "h": {"id": "C1333924", "name": "C1333924#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0082529", "name": "C0082529#ent", "pos": [10, 11]}}
{"token": ["With", "C1705878#ent", "<e1>", "being", "the", "first", "C0079429#ent", "<e2>", "found", "with", "increased", "copy", "number", "low", "grade", "glioma", "this", "study", "provides", "the", "first", "evidence", "that", "gene", "amplification", "occur", "in", "early", "tumor", "development", "."], "h": {"id": "C1705878", "name": "C1705878#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}}
{"token": ["HDL", "removes", "cholesterol", "from", "the", "arterial", "wall", "stimulates", "C0072259#ent", "<e1>", "inhibits", "adhesion", "molecules", "expression", ",", "has", "antioxidant", "properties", "protects", "against", "C0004153#ent", "<e2>", "."], "h": {"id": "C0072259", "name": "C0072259#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [20, 21]}}
{"token": ["Human", "protein", "Z", "PZ", ")", "is", "a", "62,000-Mr", ",", "C2002622#ent", "<e1>", "structure", "is", "similar", "to", "C1333523#ent", "<e2>", "IX", ",", "X", ",", "protein", "C", "and", "protein", "S", "but", "whose", "function", "is", "not", "known", "."], "h": {"id": "C2002622", "name": "C2002622#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1333523", "name": "C1333523#ent", "pos": [15, 16]}}
{"token": ["C0031923#ent", "<e1>", ",", "a", "first", "choice", "drug", "for", "C0017605#ent", "<e2>", "PACG", ")", ",", "is", "reported", "to", "produce", "shallow", "anterior", "chamber", "posterior", "synechia", "consequently", "a", "small", "immobile", "pupil", "."], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [8, 9]}}
{"token": ["Altogether", "119", "eyes", "at", "risk", "of", "developing", "C0017605#ent", "<e1>", "provoked", "with", "simultaneous", "C0031923#ent", "<e2>", "and", "phenylephrine", ";", "of", "these", "74", "developed", "C0017605#ent", "<e1>"], "h": {"id": "C0031923", "name": "C0031923#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [7, 8]}}
{"token": ["In", "conclusion", ",", "in", "areas", "with", "a", "high", "frequency", "of", "tuberculous", "strains", "a", "primary", "resistance", "isoniazid", ",", "a", "9-month", "regimen", "of", "rifampicin", ",", "isoniazid", "and", "C0014964#ent", "<e1>", "is", "recommended", "for", "C0041316#ent", "<e2>"], "h": {"id": "C0014964", "name": "C0014964#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0041316", "name": "C0041316#ent", "pos": [30, 31]}}
{"token": ["C0118120#ent", "<e1>", "(", "Fpg", "protein", ",", "C1335081#ent", "<e2>", ")", "catalyses", "excision", "of", "8-oxoguanine", "(", "8-oxoG", ")", "and", "other", "oxidatively", "damaged", "purines", "from", "DNA", "in", "a", "glycosylase/apurinic/apyrimidinic-lyase", "reaction", "."], "h": {"id": "C0118120", "name": "C0118120#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335081", "name": "C1335081#ent", "pos": [6, 7]}}
{"token": ["Plants", "contain", "the", "genes", "for", "both", "C0118120#ent", "<e1>", "FPG", ")", "and", "C1335081#ent", "<e2>", "OGG", ")", "."], "h": {"id": "C0118120", "name": "C0118120#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335081", "name": "C1335081#ent", "pos": [11, 12]}}
{"token": ["The", "hydrolysis", "of", "amide", "compounds", "coupled", "hydrolysis", "of", "ATP", "were", "observed", "with", "C0020209#ent", "<e1>", ",", "DL-5-methylhydantoin", ",", "glutarimide", "and", "C0038623#ent", "<e2>", "in", "addition", "to", "N-methylhydantoin", "."], "h": {"id": "C0020209", "name": "C0020209#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038623", "name": "C0038623#ent", "pos": [19, 20]}}
{"token": ["Comparison", "of", "NH2-terminal", "protein", "sequence", "of", "OX44", "rat", "Ag", "and", "C1413228#ent", "<e1>", "suggest", "that", "C1413228#ent", "<e1>", "is", "the", "human", "C1334043#ent", "<e1>", "of", "OX44", "."], "h": {"id": "C1413228", "name": "C1413228#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [19, 20]}}
{"token": ["Sar1", ",", "Ile8", "]", "C2698414#ent", "<e1>", "is", "a", "potent", "and", "specific", "C0001641#ent", "<e2>", "of", "the", "pressor", "response", "to", "angiotensinII", ";", "in", "the", "adrenal", "cortex", "it", "is", "a", "much", "less", "effective", "inhibitor", "of", "aldosterone", "biosynthesis"], "h": {"id": "C2698414", "name": "C2698414#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [11, 12]}}
{"token": ["We", "wished", "to", "determine", "whether", "hMLH1", "hypermethylation", "was", "associated", "with", "C1704807#ent", "<e1>", "expression", "and", "MSI", "in", "C0021390#ent", "<e2>", "neoplasms", "."], "h": {"id": "C1704807", "name": "C1704807#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [16, 17]}}
{"token": ["Guanine", "nucleotide", "binding", "proteins", "G", "proteins", "are", "largely", "grouped", "into", "three", "classes", ":", "C0752348#ent", "<e1>", "ras-like", "or", "small", "molecular", "weight", "GTP", "binding", "proteins", "and", "others", "like", "C3539616#ent", "<e2>", "."], "h": {"id": "C0752348", "name": "C0752348#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [26, 27]}}
{"token": ["Based", "on", "these", "findings", ",", "D8-PS", "is", "investigated", "by", "C1424214#ent", "<e1>", "in", "pure", "H-toluene", "and", "three", "different", "C1705281#ent", "<e2>", "concentrations", "in", "H-toluene", "."], "h": {"id": "C1424214", "name": "C1424214#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705281", "name": "C1705281#ent", "pos": [17, 18]}}
{"token": ["Topical", "terbinafine", "also", "been", "compared", "to", "C0009074#ent", "<e1>", "for", "the", "treatment", "of", "C0040259#ent", "<e2>"], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0040259", "name": "C0040259#ent", "pos": [12, 13]}}
{"token": ["To", "evaluate", "efficiency", "of", "C0106556#ent", "<e1>", "CBS", ")", "in", "C0038354#ent", "<e2>", "induced", "by", "nonsteroid", "anti-inflammatory", "drugs", "NSAID", ")", "."], "h": {"id": "C0106556", "name": "C0106556#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0038354", "name": "C0038354#ent", "pos": [9, 10]}}
{"token": ["Specific", "inhibition", "of", "C0534519#ent", "<e1>", "by", "Ac-Asp-Glu-Val-Asp-CHO", ",", "but", "not", "by", "C0530316#ent", "<e2>", ",", "was", "accompanied", "by", "inhibition", "of", "VT-induced", "apoptosis", "in", "FMVEC", "and", "TNF-alpha-treated", "GMVEC", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0530316", "name": "C0530316#ent", "pos": [11, 12]}}
{"token": ["Staurosporine-induced", "apoptosis", "in", "myocytes", "was", "reduced", "by", "a", "cell-permeable", ",", "irreversible", "tripeptide", "inhibitor", "of", "C0534519#ent", "<e1>", ",", "ZVAD-fmk", ",", "but", "not", "by", "the", "ICE-specific", "inhibitor", "C0530316#ent", "<e2>", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0530316", "name": "C0530316#ent", "pos": [25, 26]}}
{"token": ["The", "C0271408#ent", "<e1>", "of", "three", "patients", "with", "C0521770#ent", "<e2>", "average", "age", ":", "57", "years", ")", "was", "obtained", "by", "a", "two-hand", "closed", "pars", "plana", "vitrectomy", "."], "h": {"id": "C0271408", "name": "C0271408#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0521770", "name": "C0521770#ent", "pos": [7, 8]}}
{"token": ["The", "peaks", "for", "C1257966#ent", "<e1>", "were", "absent", "in", "ether", "fraction", "those", "ones", "for", "polyacetylene", "in", "C0014996#ent", "<e2>", ":", "methanol", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0014996", "name": "C0014996#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", "we", "investigated", "some", "biological", "properties", "C1257966#ent", "<e1>", "recovered", "in", "the", "aqueous", "(", "AqE", ")", "and", "C0014996#ent", "<e2>", "(", "EtE", ")", "extracts", "from", "four", "Italian", "multifloral", "honeys", "."], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014996", "name": "C0014996#ent", "pos": [18, 19]}}
{"token": ["Whole", "blood", "choline", "WBCHO", ")", "and", "C4082696#ent", "<e1>", "PLCHO", ")", "concentrations", "increase", "rapidly", "after", "stimulation", "of", "C0031670#ent", "<e2>", "acute", "coronary", "syndromes", "ACS", ")", "."], "h": {"id": "C4082696", "name": "C4082696#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031670", "name": "C0031670#ent", "pos": [16, 17]}}
{"token": ["Topics", "included", "preeclampsia", ",", "C0085207#ent", "<e1>", "breastfeeding", "and", "weight", "loss", "C0026857#ent", "<e2>", "mental", "health", "and", "offspring", "health", "and", "development", "."], "h": {"id": "C0085207", "name": "C0085207#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026857", "name": "C0026857#ent", "pos": [10, 11]}}
{"token": ["Other", "nutraceuticals", "of", "interest", "in", "patients", "with", "cancer", "include", "C0003402#ent", "<e1>", "trace", "minerals", "glutamine", ",", "protease", "inhibitors", "garlic", ",", "tea", "polyphenols", "vitamin", "A", "and", "C0281563#ent", "<e2>"], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0281563", "name": "C0281563#ent", "pos": [24, 25]}}
{"token": ["ARDS", "occurs", "in", "patients", "with", "no", "underlying", "C0034072#ent", "<e1>", "induced", "by", "stresses", ",", "such", "as", "lung", "injury", "C0001339#ent", "<e2>", "infections", "."], "h": {"id": "C0034072", "name": "C0034072#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [17, 18]}}
{"token": ["As", "the", "C1527358#ent", "<e1>", "potential", "of", "C0033228#ent", "<e2>", "lies", "in", "the", "UVB", "and", "UVA", "range", ",", "this", "might", "be", "of", "relevance", "with", "regard", "to", "clinical", "photosensitivity"], "h": {"id": "C1527358", "name": "C1527358#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033228", "name": "C0033228#ent", "pos": [6, 7]}}
{"token": ["It", "is", "suggested", "to", "recognize", "among", "the", "VIII", "group", "registrants", "subgroups", "A", ",", "B", "and", "D", "including", "patients", "with", "C0036202#ent", "<e1>", "stable", "regression", "marked", "pneumosclerosis", "with", "C0476273#ent", "<e2>"], "h": {"id": "C0036202", "name": "C0036202#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0476273", "name": "C0476273#ent", "pos": [26, 27]}}
{"token": ["C1843247#ent", "<e1>", "CMTX1", ")", "is", "an", "C0031117#ent", "<e2>", "by", "mutations", "in", "the", "GJB1", "gene"], "h": {"id": "C1843247", "name": "C1843247#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [6, 7]}}
{"token": ["These", "C1366515#ent", "<e1>", "signals", "induced", "by", "hydroperoxide", "may", "reflect", "C0015880#ent", "<e2>", "the", "ferryl", "state", "complexed", "with", "a", "free", "radical", "from", "hydroperoxide", "or", "fragments", "of", "hydroperoxide", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015880", "name": "C0015880#ent", "pos": [9, 10]}}
{"token": ["C1366515#ent", "<e1>", "and", "UV-visible", "absorption", "purified", "recombinant", "human", "C0015880#ent", "<e2>", "provides", "evidence", "that", "NO", "is", "targeting", "the", "[", "2Fe-2S", "]", "center", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015880", "name": "C0015880#ent", "pos": [8, 9]}}
{"token": ["Multi-model", "distributions", "were", "observed", "for", "the", "fluxes", "of", "NP", "and", "C1539312#ent", "<e1>", "in", "the", "C0175699#ent", "<e2>", "with", "the", "peak", "fluxes", "occurring", "in", "the", "late", "1950s", "and", "the", "mid-1970s", "respectively", "."], "h": {"id": "C1539312", "name": "C1539312#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0175699", "name": "C0175699#ent", "pos": [14, 15]}}
{"token": ["C1413221#ent", "<e1>", "differed", "from", "cytokine-induced", "signaling", "that", "it", "did", "not", "cause", "tyrosine", "phosphorylation", "C1334290#ent", "<e2>", "and", "Jak2", "."], "h": {"id": "C1413221", "name": "C1413221#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334290", "name": "C1334290#ent", "pos": [13, 14]}}
{"token": ["However", ",", "C1260386#ent", "<e1>", "levels", "were", "enhanced", "in", "both", "wt", "and", "C4283853#ent", "<e2>", "tert-butyl", "hydroquinone", "(", "TBHQ", ")", "."], "h": {"id": "C1260386", "name": "C1260386#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283853", "name": "C4283853#ent", "pos": [11, 12]}}
{"token": ["These", "data", "indicate", "that", "leukemia", "cells", "C1335866#ent", "<e1>", "and", "SS", "reduce", "C0085940#ent", "<e2>", "with", "resultant", "suppression", "of", "leukemia", "cell", "growth", "possibly", "mediated", "by", "the", "SSTRI", "."], "h": {"id": "C1335866", "name": "C1335866#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085940", "name": "C0085940#ent", "pos": [11, 12]}}
{"token": ["These", "changes", "are", "accompanied", "by", "reduced", "expression", "of", "Hes1", "and", "C2827373#ent", "<e1>", "and", "increased", "expression", "of", "Mash1", "and", "C1417685#ent", "<e2>", "2", "."], "h": {"id": "C2827373", "name": "C2827373#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417685", "name": "C1417685#ent", "pos": [18, 19]}}
{"token": ["C2699492#ent", "<e1>", "Stearate", "was", "hydrolyzed", "to", "stearic", "acid", "anhydrides", "of", "C0037688#ent", "<e2>", "in", "the", "rat", "."], "h": {"id": "C2699492", "name": "C2699492#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037688", "name": "C0037688#ent", "pos": [10, 11]}}
{"token": ["The", "most", "common", "forms", "of", "primary", "glomerular", "diseases", "elderly", "are", "C0017665#ent", "<e1>", "focal-segmental", "glomerulosclerosis", "whereas", "diabetic", "nephropathy", "amyloidosis", "are", "common", "causes", "of", "C4288763#ent", "<e2>"], "h": {"id": "C0017665", "name": "C0017665#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C4288763", "name": "C4288763#ent", "pos": [22, 23]}}
{"token": ["Although", "C0011777#ent", "<e1>", "treatment", "significantly", "reduced", "ascites", "in", "C1416933#ent", "<e2>", "rats", ",", "the", "plasma", "albumin", "total", "protein", "levels", "decreased", "in", "fibrotic", "rats", "were", "not", "restored", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416933", "name": "C1416933#ent", "pos": [8, 9]}}
{"token": ["To", "analyze", "in", "detail", "the", "C0017363#ent", "<e1>", "encoding", "the", "C0379099#ent", "<e2>", "pma", ")", "in", "Nicotiana", "plumbaginifolia", "Viv", ".", ","], "h": {"id": "C0017363", "name": "C0017363#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [9, 10]}}
{"token": ["Desmin", "is", "cleaved", "selectively", "at", "a", "conserved", "Asp", "residue", "its", "L1-L2", "linker", "domain", "(", "C0340861#ent", "<e1>", "downward", "arrow", "M(264", ")", ")", "by", "C0538091#ent", "<e2>", "in", "vitro", "in", "myogenic", "cells", "apoptosis", "."], "h": {"id": "C0340861", "name": "C0340861#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0538091", "name": "C0538091#ent", "pos": [22, 23]}}
{"token": ["alpha-Momorcharin", ",", "beta-momorcharin", "and", "trichosanthin", "increased", "the", "secretion", "of", "glutamate-pyruvate", "transaminase", "lactate", "dehydrogenase", "C0022157#ent", "<e1>", "isolated", "rat", "C0669372#ent", "<e2>", "into", "the", "culture", "medium"], "h": {"id": "C0022157", "name": "C0022157#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [17, 18]}}
{"token": ["These", "observations", "help", "to", "account", "for", "the", "constellation", "of", "C0525041#ent", "<e1>", "individual", "patients", "with", "C1332754#ent", "<e2>", "and", "the", "difficulty", "encountered", "in", "identifying", "a", "characteristic", "psychometric", "profile", "this", "group", "of", "patients", "."], "h": {"id": "C0525041", "name": "C0525041#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332754", "name": "C1332754#ent", "pos": [14, 15]}}
{"token": ["Quantification", "of", "bacterial", "flora", "in", "C0029883#ent", "<e1>", "MEE", ")", "and", "adenoids", "in", "children", "with", "C0029882#ent", "<e2>", "effusion", "(", "OME", ")", "was", "performed", "."], "h": {"id": "C0029883", "name": "C0029883#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [14, 15]}}
{"token": ["A", "subgroup", "of", "the", "C1336652#ent", "<e1>", "composed", "of", "Edar", ",", "Troy", "and", "C1539328#ent", "<e2>", ",", "are", "implicated", "in", "the", "development", "of", "ectodermal", "appendages", "such", "as", "hair", "follicles", "teeth", "and", "sweat", "glands"], "h": {"id": "C1336652", "name": "C1336652#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1539328", "name": "C1539328#ent", "pos": [12, 13]}}
{"token": ["Methylcarbamylcholine", "(", "MCC", ")", ",", "a", "structural", "analog", "carbachol", "(", "an", "C0242897#ent", "<e1>", ",", "has", "been", "reported", "to", "be", "a", "specific", "C1413410#ent", "<e2>", "."], "h": {"id": "C0242897", "name": "C0242897#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413410", "name": "C1413410#ent", "pos": [21, 22]}}
{"token": ["Nine", "of", "the", "11", "point", "mutations", "altered", "C3539946#ent", "<e1>", "are", "identical", "in", "all", "of", "the", "C0919550#ent", "<e2>", "so", "far", ",", "suggesting", "that", "these", "C3539946#ent", "<e1>", "play", "important", "structural", "or", "functional", "roles", "in", "Fur", "activity"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0919550", "name": "C0919550#ent", "pos": [15, 16]}}
{"token": ["Three", "copies", "of", "the", "C0030350#ent", "<e1>", "found", "in", "16/51", "canine", "and", "9/22", "feline", "C0042029#ent", "<e2>", "E.", "coli", "pap", "positive", "strains", "."], "h": {"id": "C0030350", "name": "C0030350#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [13, 14]}}
{"token": ["Neoxanthin", "treatment", "increased", "the", "activities", "of", "caspase-3", ",", "-8", "and", "-9", ",", "and", "the", "protein", "levels", "their", "C0599220#ent", "<e1>", "except", "in", "the", "case", "of", "C1705065#ent", "<e2>", "."], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705065", "name": "C1705065#ent", "pos": [24, 25]}}
{"token": ["Among", "hepatotropic", "viruses", ",", "hepatitis", "C", "frequently", "is", "associated", "with", "C0267917#ent", "<e1>", "than", "is", "hepatitis", "B.", "both", "C0019163#ent", "<e2>", "hepatitis", "C", "the", "lymphocytic", "cholangitis", "duct", "damage", "reversible", "and", "does", "not", "adversely", "influence", "the", "course", "of", "disease", "or", "response", "to", "therapy"], "h": {"id": "C0267917", "name": "C0267917#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019163", "name": "C0019163#ent", "pos": [17, 18]}}
{"token": ["Around", "16", "%", "to", "45", "%", "of", "adults", "have", "C0878773#ent", "<e1>", "urgency", "with", "frequency", "and/or", "urge", "incontinence", "'", "C0878773#ent", "<e1>", ")", "."], "h": {"id": "C0878773", "name": "C0878773#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0878773", "name": "C0878773#ent", "pos": [9, 10]}}
{"token": ["Because", "C1415561#ent", "<e1>", "and", "DRB1", "genes", "independently", "associated", ",", "both", "of", "these", "C0017337#ent", "<e2>", "may", "be", "contributed", "primarily", "to", "the", "pathogenesis", "of", "type", "1", "diabetes", "Japanese", "."], "h": {"id": "C1415561", "name": "C1415561#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [12, 13]}}
{"token": ["This", "study", "provides", "evidence", "that", "C0982025#ent", "<e1>", "is", "an", "effective", "agent", "in", "acquired", "C0019069#ent", "<e2>", "and", "suitable", "for", "all", "types", "of", "patients", "regardless", "of", "severity", "of", "haemorrhage", ",", "underlying", "disease", "or", "inhibitor", "titre"], "h": {"id": "C0982025", "name": "C0982025#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [13, 14]}}
{"token": ["The", "influence", "of", "treatment", "with", "an", "activated", "prothrombin", "complex", "preparation", "C0982025#ent", "<e1>", ")", "on", "the", "antibody", "level", "was", "studied", "in", "10", "C0019069#ent", "<e2>", "with", "an", "antibody", "to", "factor", "VIII"], "h": {"id": "C0982025", "name": "C0982025#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0019069", "name": "C0019069#ent", "pos": [21, 22]}}
{"token": ["C1419786#ent", "<e1>", "is", "a", "C0280950#ent", "<e2>", "to", "be", "overexpressed", "during", "tumor", "metastasis", "formation", "."], "h": {"id": "C1419786", "name": "C1419786#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0280950", "name": "C0280950#ent", "pos": [4, 5]}}
{"token": ["The", "applied", "l-serine", ",", "l-lysine", ",", "and", "C0281255#ent", "<e1>", ",", "as", "well", "as", "C1161331#ent", "<e2>", ",", "entered", "the", "phloem", "and", "were", "transported", "to", "the", "sink", "leaf", "rates", "between", "1.16", "and", "1.83", "cm/min", "."], "h": {"id": "C0281255", "name": "C0281255#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "ABC", "values", "of", "leukocyte", "membrane", "antigens", "as", "CD16", ",", "CD46", ",", "and", "C1824670#ent", "<e1>", "on", "all", "leukocytes", "and", "CD11b", ",", "C1706507#ent", "<e2>", ",", "and", "CD35", "on", "myeloid", "cells", "not", "change", "."], "h": {"id": "C1824670", "name": "C1824670#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1706507", "name": "C1706507#ent", "pos": [23, 24]}}
{"token": ["By", "analyzing", "the", "genetic", "defect", "C1850168#ent", "<e1>", "which", "is", "characterized", "by", "a", "pyridinoline", "deficiency", "C0009325#ent", "<e2>", "we", "found", "two", "missense", "mutations", "exon", "17", "PLOD2", ",", "thereby", "identifying", "PLOD2", "as", "a", "putative", "TLH", "gene", "."], "h": {"id": "C1850168", "name": "C1850168#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [14, 15]}}
{"token": ["Although", "erythromycin", "has", "historically", "been", "used", "to", "treat", "patients", "with", "C0023241#ent", "<e1>", "newer", "macrolides", "and", "C0949665#ent", "<e2>", "are", "gaining", "acceptance", "as", "the", "first", "choice", "for", "treatment", "."], "h": {"id": "C0023241", "name": "C0023241#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0949665", "name": "C0949665#ent", "pos": [15, 16]}}
{"token": ["Five", "patients", "with", "the", "\"", "on-off", "\"", "phenomenon", "of", "C0030567#ent", "<e1>", "who", "developed", "C0013384#ent", "<e2>", "associated", "with", "reduction", "in", "akinesia", "during", "treatment", "with", "lithium", "carbonate", "described", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013384", "name": "C0013384#ent", "pos": [13, 14]}}
{"token": ["Most", "interest", "in", "the", "C0017337#ent", "<e1>", "encoding", "the", "alpha-thalassemia", ",", "mental", "retardation", "X-linked", "protein", "C1845055#ent", "<e2>", ")", "has", "traditionally", "been", "focused", "on", "its", "role", "in", "brain", "development", "globin", "regulation"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1845055", "name": "C1845055#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "provide", "evidence", "that", "redox", "properties", "of", "tetracaine", ",", "C0005059#ent", "<e1>", ",", "and", "their", "C4277608#ent", "<e2>", "correlate", "with", "their", "ability", "to", "enhance", "Na+", "channel", "inactivation", "in", "BTX-modified", "Na+", "channels", "."], "h": {"id": "C0005059", "name": "C0005059#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4277608", "name": "C4277608#ent", "pos": [15, 16]}}
{"token": ["It", "was", "demonstrated", "that", "the", "new", "sustained", "release", "formulation", "of", "C0064079#ent", "<e1>", "could", "be", "useful", "in", "clinical", "practice", "the", "treatment", "of", "angina", "pectoris", "C0018802#ent", "<e2>"], "h": {"id": "C0064079", "name": "C0064079#ent", "pos": [10, 11]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [23, 24]}}
{"token": ["C3536715#ent", "<e1>", "in", "19", "cases", "(", "associated", "with", "rheumatoid", "arthritis", "C0029443#ent", "<e2>", "in", "two-thirds", "of", "them", ")", "."], "h": {"id": "C3536715", "name": "C3536715#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [10, 11]}}
{"token": ["These", "considerations", "permitted", "us", "to", "delineate", "four", "categories", "of", "C2741638#ent", "<e1>", "The", "first", "category", "included", "C2741638#ent", "<e1>", "by", "a", "cerebral", "lesion", "manifested", "through", "C0020538#ent", "<e1>"], "h": {"id": "C2741638", "name": "C2741638#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [23, 24]}}
{"token": ["To", "examine", "whether", "C1414438#ent", "<e1>", "has", "a", "neuroprotective", "action", "the", "C0001614#ent", "<e2>", ",", "C1414438#ent", "<e1>", "was", "infused", "into", "the", "cerebroventricles", "of", "stroke-prone", "spontaneously", "hypertensive", "rats", "with", "permanent", "occlusion", "the", "left", "middle", "cerebral", "artery"], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [10, 11]}}
{"token": ["Tagging", "recombinant", "C1422836#ent", "<e1>", "with", "the", "green", "fluorescent", "protein", "GFP", ")", "and", "expressing", "the", "C1305923#ent", "<e2>", "HLtat", "transfected", "cells", "indicated", "that", "C1422836#ent", "<e1>", "is", "located", "in", "the", "nucleus", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1422836", "name": "C1422836#ent", "pos": [2, 3]}}
{"token": ["Since", "p53", "inhibits", "invasion", "and", "angiogenesis", "of", "melanoma", "cells", "we", "sought", "to", "investigate", "if", "C1334129#ent", "<e1>", "(", "one", "of", "C1334129#ent", "<e1>", "isoforms", ")", "is", "also", "involved", "in", "these", "biological", "processes"], "h": {"id": "C1334129", "name": "C1334129#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334129", "name": "C1334129#ent", "pos": [14, 15]}}
{"token": ["Both", "C0280858#ent", "<e1>", "and", "propranolol", "exerted", "an", "antiarrhythmic", "effect", "C0002575#ent", "<e2>", "induced", "ventricular", "arrhythmias"], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [9, 10]}}
{"token": ["C1815010#ent", "<e1>", "was", "shown", "to", "be", "well", "tolerated", "and", "effective", "in", "C0018802#ent", "<e2>", "patients", "in", "the", "observational", "COLA", "II", "study"], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [11, 12]}}
{"token": ["C0271407#ent", "<e1>", "a", "complication", "of", "pathological", "C0235267#ent", "<e2>", "."], "h": {"id": "C0271407", "name": "C0271407#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [6, 7]}}
{"token": ["In", "the", "present", "studies", "we", "examined", "the", "influence", "of", "the", "muscarinic", "cholinergic", "agonist", "C0006945#ent", "<e1>", "on", "intracellular", "pH", "(", "C1333690#ent", "<e2>", ")", "in", "chicken", "granulosa", "cells"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [19, 20]}}
{"token": ["Reflux", "oesophagitis", "C0043515#ent", "<e1>", "also", "healed", "by", "C0050940#ent", "<e2>", "."], "h": {"id": "C0043515", "name": "C0043515#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0050940", "name": "C0050940#ent", "pos": [7, 8]}}
{"token": ["These", "findings", "are", "consistent", "with", "existence", "at", "the", "carboxyl", "terminus", "C1705700#ent", "<e1>", "of", "a", "catalytically", "active", "domain", "capable", "of", "C0033993#ent", "<e2>", "NAD", ",", "but", "not", "of", "transferring", "ADP-ribose", "to", "a", "guanidino", "acceptor", "."], "h": {"id": "C1705700", "name": "C1705700#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033993", "name": "C0033993#ent", "pos": [19, 20]}}
{"token": ["Downregulation", "of", "C3272498#ent", "<e1>", "with", "siRNA", "decreased", "phosphorylation", "of", "C0059239#ent", "<e2>", "and", "ERK", ",", "while", "overexpression", "of", "C3272498#ent", "<e1>", "increased", "their", "phosphorylation", "."], "h": {"id": "C0059239", "name": "C0059239#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3272498", "name": "C3272498#ent", "pos": [2, 3]}}
{"token": ["The", "purpose", "of", "the", "present", "study", "was", "to", "examine", "the", "C0599295#ent", "<e1>", "lumbar", "bone", "mineral", "density", "BMD", ")", ",", "bone", "resorption", "and", "back", "pain", "C0102118#ent", "<e2>", "after", "treatment", "with", "cyclical", "etidronate", "in", "postmenopausal", "women", "with", "osteoporosis", "."], "h": {"id": "C0599295", "name": "C0599295#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0102118", "name": "C0102118#ent", "pos": [24, 25]}}
{"token": ["These", "data", "suggest", "that", "GRK6A", "phosphorylates", "C0297119#ent", "<e1>", "via", "a", "PDZ", "domain-mediated", "interaction", "and", "that", "GRK6A", "is", "the", "C0211705#ent", "<e2>", "in", "HEK-293", "cells", "responsible", "for", "the", "constitutive", "phosphorylation", "of", "C0297119#ent", "<e1>", "."], "h": {"id": "C0211705", "name": "C0211705#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0297119", "name": "C0297119#ent", "pos": [6, 7]}}
{"token": ["Parkin-associated", "endothelin", "receptor-like", "receptor", "Pael-R", ")", "is", "a", "substrate", "of", "the", "E3", "ubiquitin", "ligase", "parkin", "which", "has", "been", "implicated", "in", "C1414461#ent", "<e1>", "stress-induced", "cell", "death", "dopamine", "neurons", "in", "autosomal", "recessive", "juvenile", "parkinsonism", "C2983548#ent", "<e2>", ")", "."], "h": {"id": "C1414461", "name": "C1414461#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C2983548", "name": "C2983548#ent", "pos": [32, 33]}}
{"token": ["The", "field", "has", "benefited", "greatly", "from", "C0026837#ent", "<e1>", "cell", "biological", "biophysical", "studies", "the", "mechanism", "used", "by", "cell", "penetrating", "C0030956#ent", "<e2>", "to", "enter", "cells", "and", "deliver", "their", "cargo", "."], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [18, 19]}}
{"token": ["Southern", "blot", "experiments", "that", "C1704920#ent", "<e1>", "belongs", "to", "a", "C0017363#ent", "<e2>", "all", "or", "part", "of", "which", "has", "been", "amplified", "in", "mutant", "lines"], "h": {"id": "C1704920", "name": "C1704920#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [9, 10]}}
{"token": ["The", "active", "component", "C0770612#ent", "<e1>", "glycyrrhizin", ",", "has", "been", "shown", "to", "reduce", "alanine", "transaminase", "C0242192#ent", "<e2>", "values", "in", "the", "serum", "."], "h": {"id": "C0770612", "name": "C0770612#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242192", "name": "C0242192#ent", "pos": [14, 15]}}
{"token": ["The", "patient", "was", "implanted", "with", "a", "ventriculoperitoneal", "shunt", "a", "pseudo-tumour", "cerebri", "C0030353#ent", "<e1>", ",", "which", "eventually", "lead", "to", "C0339527#ent", "<e2>", "."], "h": {"id": "C0030353", "name": "C0030353#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0339527", "name": "C0339527#ent", "pos": [18, 19]}}
{"token": ["This", "is", "partly", "due", "to", "decreased", "release", "of", "C1522670#ent", "<e1>", "response", "to", "C2757070#ent", "<e2>", "."], "h": {"id": "C1522670", "name": "C1522670#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "assess", "the", "short-", "and", "long-term", "effects", "of", "C0005129#ent", "<e1>", "on", "HP", ",", "C0017152#ent", "<e2>", ",", "and", "symptoms", "in", "patients", "with", "NUD", "."], "h": {"id": "C0005129", "name": "C0005129#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017152", "name": "C0017152#ent", "pos": [19, 20]}}
{"token": ["The", "growing", "resistance", "of", "H.", "influenzae", "M.", "catarrhalis", "amoxycillin", ",", "due", "to", "C0005244#ent", "<e1>", "production", ",", "increases", "the", "risk", "of", "treatment", "failure", "acute", "and", "C0029883#ent", "<e2>", "."], "h": {"id": "C0005244", "name": "C0005244#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0029883", "name": "C0029883#ent", "pos": [24, 25]}}
{"token": ["The", "xanthomatous", "lesions", "in", "the", "Apoe", "knock-out", "mouse", "differed", "in", "location", "from", "C0221253#ent", "<e1>", "previously", "found", "in", "C1366529#ent", "<e2>"], "h": {"id": "C0221253", "name": "C0221253#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1366529", "name": "C1366529#ent", "pos": [17, 18]}}
{"token": ["In", "16", "patients", "with", "PF", ",", "localized", "C0043037#ent", "<e1>", "seborrhoeic", "keratoses", "observed", "when", "oral", "C3536709#ent", "<e2>", "treatment", "was", "decreased", "."], "h": {"id": "C0043037", "name": "C0043037#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536709", "name": "C3536709#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "the", "concentrations", "of", "inhibitory", "drugs", "required", "to", "maximally", "affect", "C0002335#ent", "<e1>", "closely", "resembled", "those", "mediating", "maximal", "C1382029#ent", "<e2>", "inhibition", "."], "h": {"id": "C0002335", "name": "C0002335#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [19, 20]}}
{"token": ["Significantly", "more", "often", "C0017152#ent", "<e1>", "in", "CD", "than", "C0009324#ent", "<e2>", "patients", "."], "h": {"id": "C0017152", "name": "C0017152#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [8, 9]}}
{"token": ["RSK2", "C1442905#ent", "<e1>", "is", "a", "much", "more", "selective", "peptide", "kinase", "C0672273#ent", "<e2>"], "h": {"id": "C1442905", "name": "C1442905#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0672273", "name": "C0672273#ent", "pos": [10, 11]}}
{"token": ["Cyclin", "D1", "the", "regulatory", "subunit", "mid-G(1", ")", "C0080054#ent", "<e1>", "controls", "the", "expression", "of", "numerous", "C0243037#ent", "<e2>"], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0243037", "name": "C0243037#ent", "pos": [14, 15]}}
{"token": ["Subsequently", ",", "secondary", "structural", "elements", "the", "minimal", "sequence", "were", "determined", "by", "probing", "with", "C0018364#ent", "<e1>", "V1", "and", "the", "C0012186#ent", "<e2>"], "h": {"id": "C0018364", "name": "C0018364#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0012186", "name": "C0012186#ent", "pos": [18, 19]}}
{"token": ["Since", "monoamine", "oxidase", "MAO", ")", "was", "not", "inhibited", "during", "the", "assay", ",", "the", "[3H]2-phenylethylamine", "binding", "may", "have", "been", "affected", "by", "an", "interaction", "between", "C0031399#ent", "<e1>", "and", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C0031399", "name": "C0031399#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [27, 28]}}
{"token": ["Two", "proteins", "that", "play", "key", "roles", "in", "coordinating", "stress", "are", "the", "C1705633#ent", "<e1>", "MAPK14", ")", "and", "the", "transcription", "factor", "p53", "C0079419#ent", "<e2>", ")", "."], "h": {"id": "C1705633", "name": "C1705633#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079419", "name": "C0079419#ent", "pos": [20, 21]}}
{"token": ["C1825991#ent", "<e1>", "is", "a", "C0812290#ent", "<e2>", "expression", "is", "differentially", "regulated", "in", "breast", "tumours"], "h": {"id": "C1825991", "name": "C1825991#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812290", "name": "C0812290#ent", "pos": [4, 5]}}
{"token": ["The", "group", "was", "comprised", "of", "patients", "without", "C0035086#ent", "<e1>", "and", "patients", "with", "diffuse", "parenchymal", "disease", "C4287919#ent", "<e2>", "renal", "cysts", "renal", "tumors"], "h": {"id": "C0035086", "name": "C0035086#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4287919", "name": "C4287919#ent", "pos": [15, 16]}}
{"token": ["The", "use", "of", "recombinant", "human", "IL-11", "has", "also", "been", "extended", "to", "include", "patients", "with", "prolonged", "C0040034#ent", "<e1>", ",", "such", "as", "those", "with", "C2931245#ent", "<e2>"], "h": {"id": "C0040034", "name": "C0040034#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2931245", "name": "C2931245#ent", "pos": [22, 23]}}
{"token": ["In", "vitro", "transformation", "of", "protoheme", "to", "biliverdin", "IX", "alpha", "biliverdin", "IX", "alpha", "phycobilins", "were", "previously", "shown", "to", "require", "NADPH", ",", "ferredoxin", ",", "and", "ferredoxin-NADP+", "reductase", "as", "well", "as", "specific", "C0538674#ent", "<e1>", "phycobilin", "formation", "C3540772#ent", "<e2>", "."], "h": {"id": "C0538674", "name": "C0538674#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [33, 34]}}
{"token": ["The", "following", "drugs", "seem", "to", "cause", "pancreatitis", ":", "azathioprine", ",", "C0304489#ent", "<e1>", "and", "hydrochlorothiazide", ",", "oestrogens", ",", "frusemide", ",", "6-mercaptopurine", ",", "C3540782#ent", "<e2>", ",", "sulphonamides", ",", "sulindac", ",", "tetracycline", "and", "valproic", "acid"], "h": {"id": "C0304489", "name": "C0304489#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3540782", "name": "C3540782#ent", "pos": [21, 22]}}
{"token": ["We", "suggest", "that", "male", "cases", "of", "C1852502#ent", "<e1>", "should", "undergo", "C1414083#ent", "<e2>", "if", "there", "is", "calf", "hypertrophy", "markedly", "elevated", "CK", "(", ">", "2000", "U/l", ")", "."], "h": {"id": "C1852502", "name": "C1852502#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [10, 11]}}
{"token": ["These", "results", "reveal", "novel", "roles", "for", "C1418627#ent", "<e1>", "in", "helping", "to", "process", "C1956096#ent", "<e2>", "sorting", "into", "MVBs", "."], "h": {"id": "C1418627", "name": "C1418627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956096", "name": "C1956096#ent", "pos": [12, 13]}}
{"token": ["With", "C0699918#ent", "<e1>", "an", "excellent", "correlation", "is", "observed", "between", "C0915195#ent", "<e2>", "and", "the", "infrared", "carbonyl-stretching", "frequency", "of", "the", "inhibitor", "."], "h": {"id": "C0699918", "name": "C0699918#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0915195", "name": "C0915195#ent", "pos": [9, 10]}}
{"token": ["In", "summary", ",", "in", "this", "study", ",", "we", "found", "that", "C0360714#ent", "<e1>", "such", "as", "pravastatin", "and", "cerivastatin", "inhibited", "C0947751#ent", "<e2>", "arteriosclerosis", "through", "their", "lipid-lowering", "independent", "actions", "in", "this", "model", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0947751", "name": "C0947751#ent", "pos": [18, 19]}}
{"token": ["On", "the", "case", "of", "27", "old", "woman", "with", "clinical", "symptoms", "acute", "abdomen", "severe", "electrolyte", "disturbances", "and", "attacks", "of", "C0036572#ent", "<e1>", "different", "clinical", "masks", "actual", "treatment", "guidelines", "C0162565#ent", "<e2>", "presented", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [18, 19]}, "relation": "manifestation_of", "t": {"id": "C0162565", "name": "C0162565#ent", "pos": [26, 27]}}
{"token": ["C0011882#ent", "<e1>", "other", "chronic", "pain", "syndromes", "also", "shown", "to", "benefit", "from", "C0245561#ent", "<e2>", "and", "venlafaxine", "."], "h": {"id": "C0011882", "name": "C0011882#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0245561", "name": "C0245561#ent", "pos": [11, 12]}}
{"token": ["To", "evaluate", "the", "impact", "of", "baseline", "disease", "variables", "related", "to", "diabetes", "and", "C0011882#ent", "<e1>", "severity", "on", "efficacy", "and", "safety", "of", "C0245561#ent", "<e2>", "in", "the", "management", "of", "diabetic", "peripheral", "neuropathic", "pain"], "h": {"id": "C0011882", "name": "C0011882#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0245561", "name": "C0245561#ent", "pos": [20, 21]}}
{"token": ["Neurons", "that", "contain", "GAD", "also", "receive", "a", "C0242898#ent", "<e1>", "input", "in", "the", "SNR", "and", "C1420280#ent", "<e2>", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420280", "name": "C1420280#ent", "pos": [14, 15]}}
{"token": ["This", "study", "demonstrates", "a", "strong", "C0242898#ent", "<e1>", "input", "onto", "nigral", "dopaminergic", "neurons", "C0242898#ent", "<e1>", "neurons", "in", "the", "SNR", "and", "C1420280#ent", "<e1>", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420280", "name": "C1420280#ent", "pos": [19, 20]}}
{"token": ["Liver", "microsomes", "contain", "an", "enzyme", "which", "catalyzes", "the", "reduction", "of", "the", "epoxide", "to", "the", "vitamin", ",", "C0148517#ent", "<e1>", "and", "a", "number", "of", "C0030016#ent", "<e2>"], "h": {"id": "C0148517", "name": "C0148517#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [22, 23]}}
{"token": ["The", "authors", "emphasized", "that", "these", "lesions", "might", "be", "similar", "to", "those", "observed", "in", "C0015634#ent", "<e1>", "lung", "or", "extrinsic", "allergic", "alveolitis", "C0243046#ent", "<e2>", ")", "."], "h": {"id": "C0015634", "name": "C0015634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [20, 21]}}
{"token": ["The", "C3889265#ent", "<e1>", "values", "of", "C0033229#ent", "<e2>", "on", "the", "alpha-adrenergic", ",", "muscarinic", "and", "histaminic", "(", "H1", ")", "receptors", "are", "8.96", ",", "7.17", ",", "and", "7.90", ",", "respectively", "."], "h": {"id": "C3889265", "name": "C3889265#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033229", "name": "C0033229#ent", "pos": [5, 6]}}
{"token": ["The", "highest", "heterogeneity", "LOD", "score", "was", "obtained", "for", "chromosome", "12", "in", "an", "interval", "containing", "CEP290", ",", "a", "C0079429#ent", "<e1>", "recently", "identified", "as", "causative", "of", "C0431399#ent", "<e2>", "JS", ")", "and", "isolated", "Leber", "congenital", "amaurosis"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0431399", "name": "C0431399#ent", "pos": [24, 25]}}
{"token": ["The", "breakpoint", "was", "located", "C1427959#ent", "<e1>", "to", "the", "Miller-Dieker", "syndrome", "C3273937#ent", "<e2>", ")", "marker", "(", "D17S379", ")", ",", "and", "telomeric", "to", "the", "marker", "D17S1566", ",", "which", "is", "located", "C1427959#ent", "<e1>", "to", "the", "LIS1", "gene"], "h": {"id": "C1427959", "name": "C1427959#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3273937", "name": "C3273937#ent", "pos": [10, 11]}}
{"token": ["Our", "objective", "was", "to", "investigate", "the", "effect", "of", "C0071097#ent", "<e1>", "on", "bone", "mineral", "density", "BMD", ")", "and", "bone", "turnover", "markers", "C0032460#ent", "<e2>", "PCOS", ")", "."], "h": {"id": "C0071097", "name": "C0071097#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032460", "name": "C0032460#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "C0044013#ent", "<e1>", "is", "converted", "to", "p-benzoquinone", "and", "C0001962#ent", "<e2>", "."], "h": {"id": "C0044013", "name": "C0044013#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [9, 10]}}
{"token": ["A", "protein", "of", "62", "C1839259#ent", "<e1>", "is", "a", "substrate", "of", "a", "C1413098#ent", "<e2>", "and", "both", "proteins", "copurify", "with", "isolated", "mitotic", "apparatuses", "Dinsmore", ",", "J.", "H.", ",", "and", "R.", "D.", "Sloboda", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413098", "name": "C1413098#ent", "pos": [11, 12]}}
{"token": ["After", "stopping", "C0002600#ent", "<e1>", "(", "3", "months", "later", ")", "C0015043#ent", "<e2>", "was", "also", "stopped", "and", "the", "patient", "remained", ",", "as", "before", ",", "seizure-free", "on", "valproic", "acid", "monotherapy", "."], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015043", "name": "C0015043#ent", "pos": [9, 10]}}
{"token": ["The", "effect", "of", "cannabinoid", "on", "the", "tyrosine", "phosphorylation", "C1366894#ent", "<e1>", "FAK", ")", "and", "focal", "adhesion", "kinase-related", "non-kinase", "C1565427#ent", "<e2>", ")", "was", "investigated", "in", "differentiated", "mouse", "neuroblastoma", "N1E-115", "cells", "."], "h": {"id": "C1366894", "name": "C1366894#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [17, 18]}}
{"token": ["FR172516", "showed", "more", "potent", "hypotensive", "action", "C0051696#ent", "<e1>", "when", "administered", "intravenously", "to", "C0968917#ent", "<e2>", ",", "and", "apparent", "bradycardia", "was", "seen", "only", "with", "FR172516", "."], "h": {"id": "C0051696", "name": "C0051696#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0968917", "name": "C0968917#ent", "pos": [12, 13]}}
{"token": ["C0037926#ent", "<e1>", "an", "extremely", "serious", "complication", "of", "hereditary", "multiple", "exostoses", "C1417201#ent", "<e2>", ")", "."], "h": {"id": "C0037926", "name": "C0037926#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417201", "name": "C1417201#ent", "pos": [10, 11]}}
{"token": ["Overall", ",", "imipenem", ",", "C0025872#ent", "<e1>", "and", "chloramphenicol", "were", "the", "most", "active", "C1136254#ent", "<e2>", "anaerobic", "bacteria", "by", "clindamycin", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [4, 5]}, "relation": "has_therapeutic_class", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [12, 13]}}
{"token": ["Inhibitors", "of", "protein", "kinase", "C", "C0769224#ent", "<e1>", "and", "protein", "tyrosine", "kinases", "not", "block", "the", "inhibitory", "effect", "of", "C1333711#ent", "<e2>", "."], "h": {"id": "C0769224", "name": "C0769224#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333711", "name": "C1333711#ent", "pos": [17, 18]}}
{"token": ["CSF", "examination", "showed", "some", "uncommon", "features", "of", "C0025297#ent", "<e1>", "predominance", "of", "C0064833#ent", "<e2>", "PMN", ")", "was", "noted", "in", "62.5", "%", "of", "patients", "and", "hypoglycorrhachia", "in", "64", "%", "of", "patients", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [11, 12]}}
{"token": ["Peripheral", "lung", "infiltrates", "C0014457#ent", "<e1>", "a", "rare", "side", "effect", "C2239905#ent", "<e2>", "therapy", "."], "h": {"id": "C0014457", "name": "C0014457#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2239905", "name": "C2239905#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", "to", "IL-4-derived", "DCs", ",", "IFN-alpha-derived", "DCs", "were", "CD14", "+", ",", "CD1a-", ",", "CD123", "+", ",", "C1414554#ent", "<e1>", "and", "CD38", "+", "and", "expressed", "high", "levels", "of", "C1413243#ent", "<e2>", "and", "MHC", "class", "II"], "h": {"id": "C1414554", "name": "C1414554#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413243", "name": "C1413243#ent", "pos": [27, 28]}}
{"token": ["We", "present", "here", "a", "series", "of", "21", "cases", "(", "including", "15", "unreported", "patients", ")", "with", "C0342784#ent", "<e1>", "describe", "mitochondrial", "DNA", "deletions", "consistent", "features", "in", "this", "C0039082#ent", "<e2>", "."], "h": {"id": "C0342784", "name": "C0342784#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [25, 26]}}
{"token": ["C0342784#ent", "<e1>", "PS", ")", "is", "an", "uncommon", "specific", "C0039082#ent", "<e2>", "among", "mitochondrial", "diseases"], "h": {"id": "C0342784", "name": "C0342784#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}}
{"token": ["In", "this", "work", ",", "we", "describe", "a", "rational", "approach", "to", "the", "optimization", "of", "hit", "compounds", "discovered", "during", "screening", "of", "a", "C0031727#ent", "<e1>", "focused", "library", "against", "C1439337#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [20, 21]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1439337", "name": "C1439337#ent", "pos": [25, 26]}}
{"token": ["C1333828#ent", "<e1>", "are", "involved", "in", "synthesis", "of", "various", "glycolipids", "and", "C0072522#ent", "<e2>", "that", "play", "important", "roles", "in", "many", "biological", "processes"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [10, 11]}}
{"token": ["The", "glycosylation", "patterns", "of", "recombinant", "therapeutic", "glycoproteins", "be", "engineered", "by", "overexpression", "of", "C1333828#ent", "<e1>", "in", "the", "host", "cells", "for", "C0072522#ent", "<e2>", "production", "."], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [19, 20]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "clarify", "the", "effect", "of", "C0011847#ent", "<e1>", "on", "aortic", "NO", "synthesis", "in", "a", "model", "of", "C0598428#ent", "<e2>", "determine", "whether", "captopril", "modulates", "this", "effect", "."], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0598428", "name": "C0598428#ent", "pos": [21, 22]}}
{"token": ["Cellular", "responses", "C0700349#ent", "<e1>", "were", "microvilli", "formation", ",", "reduction", "in", "C0007906#ent", "<e2>", "chloride-stainable", "surface", "coat", "and", "epithelial", "dissociation", "with", "thinning", "of", "the", "basement", "membrane"], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007906", "name": "C0007906#ent", "pos": [10, 11]}}
{"token": ["Its", "major", "metabolite", ",", "C0008161#ent", "<e1>", "widely", "used", "as", "a", "C0020592#ent", "<e2>", "in", "both", "adults", "and", "children", ",", "is", "in", "danger", "of", "being", "banned", "by", "comparable", "studies", "."], "h": {"id": "C0008161", "name": "C0008161#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [10, 11]}}
{"token": ["The", "binding", "of", "five", "barbiturates", ":", "amylobarbitone", ",", "secbutobarbitone", ",", "C0030883#ent", "<e1>", ",", "phenobarbitone", "and", "quinalbarbitone", "to", "human", "serum", "albumin", "C0304925#ent", "<e2>", ")", "was", "studied", "by", "difference", "spectroscopy", "and", "spectrofluorimetric", "titrations", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0304925", "name": "C0304925#ent", "pos": [20, 21]}}
{"token": ["Inhibition", "of", "C0020289#ent", "<e1>", "orthovanadate", "also", "C2350558#ent", "<e2>", "cell", "surface", "transferrin", "receptors", "altered", "cell", "surface", "receptor", "expression", ",", "in", "a", "concentration-dependent", "manner", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [6, 7]}}
{"token": ["C0536036#ent", "<e1>", "is", "a", "potent", "anticancer", "natural", "product", "lowers", "the", "mRNA", "levels", "of", "C0037207#ent", "<e2>", "and", "tumor", "suppressor", "genes"], "h": {"id": "C0536036", "name": "C0536036#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037207", "name": "C0037207#ent", "pos": [13, 14]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "compare", "secretin", "MRCP", "and", "pancreatic", "sphincter", "Oddi", "manometry", "for", "evaluation", "of", "sphincter", "of", "C0878588#ent", "<e1>", "patients", "with", "C0149521#ent", "<e2>"], "h": {"id": "C0878588", "name": "C0878588#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0149521", "name": "C0149521#ent", "pos": [24, 25]}}
{"token": ["Immunocytochemistry", "indicated", "that", "C0300252#ent", "<e1>", "was", "expressed", "predominantly", "on", "the", "plasma", "membrane", "C0812281#ent", "<e2>", "17/2.8", "cells", "."], "h": {"id": "C0300252", "name": "C0300252#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [12, 13]}}
{"token": ["In", "mouse", "models", "C0338395#ent", "<e1>", "sepsis", "and", "of", "C0025295#ent", "<e2>", "lower", "release", "of", "proinflammatory", "bacterial", "compounds", "was", "associated", "with", "reduced", "mortality", "."], "h": {"id": "C0338395", "name": "C0338395#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025295", "name": "C0025295#ent", "pos": [8, 9]}}
{"token": ["To", "investigate", "ultrastructural", "alterations", "in", "the", "distribution", "of", "collagen", "fibrils", "C0015674#ent", "<e1>", ")", "and", "proteoglycans", "(", "C0796254#ent", "<e2>", ")", "in", "the", "keratoconus", "cornea", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [16, 17]}}
{"token": ["TAP", "is", "a", "trimeric", "complex", "of", "TAP1", ",", "C1704920#ent", "<e1>", ",", "and", "tapasin", "(", "C1705397#ent", "<e2>", ")", "as", "indicated", "for", "human", "cells", "reciprocal", "coprecipitation", "with", "anti-TAP1/2", "and", "anti-tapasin", "antibodies", ",", "respectively", "."], "h": {"id": "C1704920", "name": "C1704920#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [14, 15]}}
{"token": ["C0276623#ent", "<e1>", "HBV", ")", "infection", ",", "which", "can", "lead", "to", "C1623038#ent", "<e2>", "and", "hepatocellular", "carcinoma", "is", "a", "major", "health", "threat", "."], "h": {"id": "C0276623", "name": "C0276623#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1623038", "name": "C1623038#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "C0042523#ent", "<e1>", "is", "safe", "and", "effective", "in", "the", "therapy", "of", "C0002963#ent", "<e2>"], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0002963", "name": "C0002963#ent", "pos": [13, 14]}}
{"token": ["Inhibition", "of", "MAPK14", "(", "also", "known", "as", "p38", "MAPK", "resulted", "in", "a", "reduction", "of", "C1333928#ent", "<e1>", "phosphorylation", "and", "an", "increase", "in", "cell", "death", "C0040963#ent", "<e2>", "cell", "differentiation"], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040963", "name": "C0040963#ent", "pos": [23, 24]}}
{"token": ["DNA", "fragment", "probes", "used", "to", "determine", "the", "distribution", "of", "specific", "C0079941#ent", "<e1>", "two", "distinct", "collections", "of", "mercury-resistant", "(", "Hgr", ")", "C0085423#ent", "<e2>"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085423", "name": "C0085423#ent", "pos": [20, 21]}}
{"token": ["C0271901#ent", "<e1>", "a", "common", "condition", "in", "clinical", "practice", "C0472762#ent", "<e2>", "has", "to", "be", "considered", "as", "a", "differential", "diagnosis"], "h": {"id": "C0271901", "name": "C0271901#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0472762", "name": "C0472762#ent", "pos": [8, 9]}}
{"token": ["None", "of", "the", "organisms", "examined", "had", "C0051604#ent", "<e1>", "activity", "which", "could", "have", "contributed", "to", "C0022956#ent", "<e2>", "production", "from", "aminoacetone", "."], "h": {"id": "C0051604", "name": "C0051604#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022956", "name": "C0022956#ent", "pos": [14, 15]}}
{"token": ["It", "appeared", "from", "the", "study", "on", "metacarpal", "bone", "explants", "that", "fibroblasts", "in", "perichondrium", "and", "C0151846#ent", "<e1>", "contained", "a", "relatively", "high", "C1332804#ent", "<e2>", "activity", "whereas", "chondrocytes", "showed", "a", "low", "but", "distinct", "activity", "."], "h": {"id": "C0151846", "name": "C0151846#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332804", "name": "C1332804#ent", "pos": [20, 21]}}
{"token": ["In", "this", "paper", ",", "techniques", "are", "demonstrated", "for", "unambiguously", "mapping", "phosphoproteins", "and", "C0072522#ent", "<e1>", "into", "a", "protein", "database", "unfractionated", "C4255177#ent", "<e2>"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4255177", "name": "C4255177#ent", "pos": [19, 20]}}
{"token": ["To", "evaluate", "the", "effectiveness", "of", "eletriptan", "as", "a", "treatment", "for", "acute", "migraine", "patients", "who", "were", "poor", "responders", "to", "C0720328#ent", "<e1>", "and", "had", "not", "yet", "been", "exposed", "to", "C1567966#ent", "<e2>", "."], "h": {"id": "C0720328", "name": "C0720328#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1567966", "name": "C1567966#ent", "pos": [27, 28]}}
{"token": ["A", "relatively", "tight", "association", "between", "this", "C0031727#ent", "<e1>", "and", "C1458146#ent", "<e2>", "demonstrated", "by", "the", "ability", "to", "coprecipitate", "the", "C0031727#ent", "<e1>", "with", "scleroderma", "autoimmune", "anti-Topo", "I", "antibodies"], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [6, 7]}}
{"token": ["Inhibition", "of", "the", "prostaglandin", "C0009227#ent", "<e1>", "cyclooxygenase", ",", "by", "C0003211#ent", "<e2>", "NSAIDs", ")", ",", "is", "associated", "with", "increased", "gastroduodenal", "mucosal", "damage", "and", "ulceration", "."], "h": {"id": "C0009227", "name": "C0009227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [9, 10]}}
{"token": ["This", "suggested", "that", "our", "results", "were", "due", "to", "inhibition", "of", "C1414968#ent", "<e1>", "possibly", "as", "a", "consequence", "of", "NAD", "depletion", "following", "C0032405#ent", "<e2>"], "h": {"id": "C1414968", "name": "C1414968#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032405", "name": "C0032405#ent", "pos": [20, 21]}}
{"token": ["A", "decade", "after", "losing", "favor", "as", "an", "'", "uninteresting", "'", "C0544420#ent", "<e1>", "pancreatic", "ribonuclease", "been", "found", "to", "be", "C1334043#ent", "<e2>", "to", "a", "series", "of", "extracellular", "proteins", "may", "influence", "tumor", "cell", "growth", "neurological", "development", "biological", "differentiation"], "h": {"id": "C0544420", "name": "C0544420#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["Ag", ",", "UO(2", ")", ",", "and", "C1420423#ent", "<e1>", "also", "inhibit", "the", "C0058980#ent", "<e2>", "fraction", "of", "alanine", "influx", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [11, 12]}}
{"token": ["We", "show", "that", "C1328049#ent", "<e1>", "is", "tyrosine-phosphorylated", "in", "Jurkat", "TAg", "T", "cells", "which", "requires", "expression", "of", "the", "C1333577#ent", "<e2>", "Lck", "and", "Fyn", "."], "h": {"id": "C1328049", "name": "C1328049#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333577", "name": "C1333577#ent", "pos": [17, 18]}}
{"token": ["In", "view", "of", "these", "results", ",", "and", "comparing", "them", "with", "apparent", "C1420369#ent", "<e1>", "IC50", "values", "as", "reported", "in", "the", "literature", ",", "C0025859#ent", "<e2>", "can", "be", "considered", "a", "relatively", "beta-1", "selective", "agent", "."], "h": {"id": "C1420369", "name": "C1420369#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0025859", "name": "C0025859#ent", "pos": [21, 22]}}
{"token": ["A", "C3265462#ent", "<e1>", "active", "on", "C0054685#ent", "<e2>", "and", "on", "other", "CBZ-dipeptides", "with", "a", "pH", "optimum", "of", "5.5", "has", "been", "partially", "purified", "by", "CM-cellulose", "chromatography"], "h": {"id": "C3265462", "name": "C3265462#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054685", "name": "C0054685#ent", "pos": [5, 6]}}
{"token": ["Mutation", "screening", "of", "C1826340#ent", "<e1>", "in", "a", "panel", "of", "C2698412#ent", "<e2>", "patient", "DNA", "samples", "to", "identify", "patient-specific", "mutations"], "h": {"id": "C1826340", "name": "C1826340#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2698412", "name": "C2698412#ent", "pos": [9, 10]}}
{"token": ["However", ",", "pups", "exposed", "to", "C0166979#ent", "<e1>", "marked", ",", "ODC", "responses", "to", "these", "same", "C0035064#ent", "<e2>", "as", "early", "as", "10", "to", "19", "days", "of", "postnatal", "age", "accompanied", "by", "a", "significant", "renal", "hypertrophy"], "h": {"id": "C0166979", "name": "C0166979#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "show", "that", "C0812253#ent", "<e1>", "associates", "independently", "with", "Cbl", "or", "C1423078#ent", "<e2>", "and", "suggest", "that", "it", "also", "participates", "in", "larger", "complexes", "containing", "Cbl", "and", "C1423078#ent", "<e2>", "."], "h": {"id": "C0812253", "name": "C0812253#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1423078", "name": "C1423078#ent", "pos": [11, 12]}}
{"token": ["This", "inhibition", "of", "C0812215#ent", "<e1>", "hyperphosphorylation", "resulted", "in", "increased", "kinase", "activity", "C0812215#ent", "<e1>", "and", "increased", "phosphorylation", "of", "C0752313#ent", "<e1>", ",", "suggesting", "that", "the", "hyperphosphorylation", "of", "C0812215#ent", "<e1>", "inhibits", "its", "MEK", "kinase", "activity"], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [3, 4]}, "relation": "exhibited_by", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [17, 18]}}
{"token": ["Obesity", "is", "a", "major", "risk", "factor", "insulin", "resistance", "C0011849#ent", "<e1>", ",", "hypertension", ",", "cancer", ",", "C0016977#ent", "<e2>", "and", "atherosclerosis", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0016977", "name": "C0016977#ent", "pos": [15, 16]}}
{"token": ["The", "distinction", "between", "C1424852#ent", "<e1>", "and", "cone", "photoreceptor", "cells", "based", "on", "their", "location", ",", "morphology", ",", "C0082874#ent", "<e2>", "pattern", "and", "the", "electron", "density", "their", "inner", "segments"], "h": {"id": "C1424852", "name": "C1424852#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0082874", "name": "C0082874#ent", "pos": [16, 17]}}
{"token": ["In", "order", "to", "elucidate", "the", "NAD-recycling", "pathway", "following", "enzyme", "activities", "been", "characterized", "in", "different", "tobacco", "tissues", "and", "in", "tomato", "root", "NAD", "pyrophosphatase", "nicotinamide", "mononucleotide", "(NMN)/nicotinic", "acid", "mononucleotide", "NaMN", ")", "C0027277#ent", "<e1>", ",", "nicotinamidase", "and", "C1826348#ent", "<e2>"], "h": {"id": "C0027277", "name": "C0027277#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C1826348", "name": "C1826348#ent", "pos": [34, 35]}}
{"token": ["The", "patients", "graded", "C1260880#ent", "<e1>", "congestion", ",", "and", "C0031350#ent", "<e2>", "and", "sneezes", "were", "counted", "."], "h": {"id": "C1260880", "name": "C1260880#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [8, 9]}}
{"token": ["With", "the", "exception", "of", "methacholine", ",", "all", "substances", "caused", "symptoms", "of", "C1260880#ent", "<e1>", ",", "congestion", ",", "and", "C0031350#ent", "<e2>"], "h": {"id": "C1260880", "name": "C1260880#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [17, 18]}}
{"token": ["beta-", "And", "alpha", "1-adrenoceptor", "antagonist", "properties", "of", "bufuralol", ",", "carvedilol", ",", "C0055021#ent", "<e1>", ",", "dilevalol", ",", "labetalol", ",", "and", "C0031937#ent", "<e2>", "were", "investigated", "in", "human", "myocardium", "and", "mammary", "artery", "binding", "techniques", "functional", "studies", "."], "h": {"id": "C0055021", "name": "C0055021#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031937", "name": "C0031937#ent", "pos": [19, 20]}}
{"token": ["Dural", "ectasia", "defined", "as", "a", "ballooning", "of", "the", "dural", "sac", "is", "more", "common", "in", "patients", "with", "C0009782#ent", "<e1>", "as", "the", "C0024796#ent", "<e2>"], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [16, 17]}, "relation": "related_to", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [20, 21]}}
{"token": ["The", "aortic", "lesions", "similar", "to", "those", "described", "in", "other", "C0009782#ent", "<e1>", "particularly", "the", "C0024796#ent", "<e2>"], "h": {"id": "C0009782", "name": "C0009782#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0024796", "name": "C0024796#ent", "pos": [13, 14]}}
{"token": ["In", "mammals", ",", "C0392514#ent", "<e1>", "exists", "in", "three", "homologs", ":", "Desert", "hedgehog", "Dhh", ")", ",", "C1416377#ent", "<e2>", "Ihh", ")", "and", "Sonic", "hedgehog", "Shh", ")", "."], "h": {"id": "C0392514", "name": "C0392514#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416377", "name": "C1416377#ent", "pos": [15, 16]}}
{"token": ["On", "the", "other", "hand", ",", "non", "MHC", "encoded", "C1417679#ent", "<e1>", "are", "CCR5", ",", "CCR2", ",", "RANTES", ",", "CXCL12", ",", "C1332824#ent", "<e2>", ",", "CCL3L1", ",", "Interleukin-10", "(", "IL-10", ")", ",", "and", "interferon", "gamma"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332824", "name": "C1332824#ent", "pos": [19, 20]}}
{"token": ["Only", "hydroxyurea", "has", "shown", "significant", "clinical", "effects", "terms", "of", "reduction", "of", "pain-crises", ",", "C0742343#ent", "<e1>", "transfusions", "in", "C0002895#ent", "<e2>", "patients", "."], "h": {"id": "C0742343", "name": "C0742343#ent", "pos": [13, 14]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [17, 18]}}
{"token": ["Under", "diabetic", "and", "C0271801#ent", "<e1>", "conditions", ",", "both", "currents", "were", "also", "augmented", "by", "an", "C3850097#ent", "<e2>", "PD142893", ")", "or", "by", "an", "endothelin-converting", "enzyme", "inhibitor"], "h": {"id": "C0271801", "name": "C0271801#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3850097", "name": "C3850097#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "the", "C1705616#ent", "<e1>", "and", "WAVE", "family", "proteins", "C1705616#ent", "<e1>", "and", "N-WASP", ",", "and", "WAVE1", ",", "C4084757#ent", "<e1>", "and", "WAVE3", "have", "been", "shown", "to", "regulate", "cortical", "actin", "reorganization", "in", "response", "to", "extracellular", "stimuli", "."], "h": {"id": "C1705616", "name": "C1705616#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4084757", "name": "C4084757#ent", "pos": [17, 18]}}
{"token": ["To", "describe", "a", "case", "of", "a", "65-year-old", "woman", "with", "persistent", "C0233765#ent", "<e1>", "delusional", "self-reference", "successfully", "treated", "by", "C0299792#ent", "<e2>", "augmentation", "of", "antidepressant", "therapy"], "h": {"id": "C0233765", "name": "C0233765#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0299792", "name": "C0299792#ent", "pos": [17, 18]}}
{"token": ["Phosphodiesterase", "activity", "not", "related", "to", "the", "extent", "or", "activity", "of", "the", "C0007761#ent", "<e1>", "the", "presence", "or", "absence", "of", "C0035204#ent", "<e2>"], "h": {"id": "C0007761", "name": "C0007761#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [18, 19]}}
{"token": ["These", "results", "could", "indicate", "distinct", "behavior", "of", "the", "C1706373#ent", "<e1>", "and", "ADPase", "activities", "of", "NTPDase", "1", "relation", "to", "C0017789#ent", "<e2>", "or", "the", "simultaneous", "action", "of", "the", "ecto-ATPase", "."], "h": {"id": "C1706373", "name": "C1706373#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [18, 19]}}
{"token": ["With", "C0032483#ent", "<e1>", "however", ",", "only", "a", "limited", "C0063220#ent", "<e2>", "skin", "concentration", "(", "0.38+/-0", "-", "34", "microg", "g(-1", ")", ",", "n", "=", "5", ")", "was", "achieved", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0063220", "name": "C0063220#ent", "pos": [8, 9]}}
{"token": ["To", "elucidate", "the", "role", "of", "physical", "activity", "the", "pathogenesis", "of", "C0001363#ent", "<e1>", "patients", "with", "C1956346#ent", "<e2>", "CAD", ")", ",", "we", "hypothesized", "that", "platelet", "activation", "when", "coronary", "blood", "flow", "velocity", "shear", "stress", "increase", "across", "an", "atherosclerotic", "vascular", "bed"], "h": {"id": "C0001363", "name": "C0001363#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["The", "fact", "that", "C0003504#ent", "<e1>", "is", "inhibited", "by", "C0733397#ent", "<e2>", "and", "not", "by", "indomethacin", "indicates", "that", "the", "lipoxygenase", ",", "rather", "than", "prostaglandin-synthetase", ",", "is", "involved", "in", "the", "mechanism", "of", "C0003504#ent", "<e1>", "."], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0733397", "name": "C0733397#ent", "pos": [8, 9]}}
{"token": ["Response", "of", "sugar", "beet", "cultivars", "C1540219#ent", "<e1>", "and", "USH11", "to", "syringe", "infiltration", "live", "and", "dead", "Bacillus", "mycoides", "C1875400#ent", "<e2>", "Bac", "J", "a", "biological", "control", "agent", "and", "virulent", "and", "avirulent", "isolates", "of", "Erwinia", "carotovora", "pv"], "h": {"id": "C1540219", "name": "C1540219#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [17, 18]}}
{"token": ["C0001962#ent", "<e1>", "was", "also", "approximately", "3-fold", "more", "effective", "than", "C0006180#ent", "<e2>", "in", "identifying", "leucine-rich", "repeat", "receptor-like", "kinases"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006180", "name": "C0006180#ent", "pos": [9, 10]}}
{"token": ["C0069535#ent", "<e1>", "was", "efficiently", "expressed", "by", "cloning", "the", "C1335093#ent", "<e2>", "GST", "fusion", "expression", "vector"], "h": {"id": "C0069535", "name": "C0069535#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335093", "name": "C1335093#ent", "pos": [8, 9]}}
{"token": ["Human", "epidermal", "cells", "cultured", "with", "C0030807#ent", "<e1>", "the", "presence", "of", "hydrocortisone", ",", "C0700546#ent", "<e2>", "dapsone", "and", "gold", "."], "h": {"id": "C0030807", "name": "C0030807#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0700546", "name": "C0700546#ent", "pos": [12, 13]}}
{"token": ["Stimulation", "by", "isoprenaline", "of", "renal", "and", "C1382029#ent", "<e1>", "blocked", "by", "C0033497#ent", "<e2>", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [10, 11]}}
{"token": ["Non-receptor", "mediated", "stimulation", "of", "C1382029#ent", "<e1>", "by", "manganese", "ion", "forskolin", "and", "NaF", "is", "similarly", "enhanced", "following", "C0033497#ent", "<e2>", "pretreatment", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [16, 17]}}
{"token": ["Macrophages", "from", "other", "pathological", "processes", "closely", "resembling", "malakoplakia", "cells", "without", "M.G.", "bodies", ",", "did", "not", "contain", "C1418544#ent", "<e1>", ",", "except", "for", "a", "few", "macrophages", "in", "tuberculosis", "and", "C0034188#ent", "<e2>"], "h": {"id": "C1418544", "name": "C1418544#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034188", "name": "C0034188#ent", "pos": [27, 28]}}
{"token": ["C1563719#ent", "<e1>", "hypogonadotrophic", "hypogonadism", "anosmia", "or", "hyposmia", ")", "associated", "with", "C2720163#ent", "<e2>", "due", "to", "a", "contiguous", "gene", "syndrome", "is", "an", "uncommon", "finding", "."], "h": {"id": "C1563719", "name": "C1563719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2720163", "name": "C2720163#ent", "pos": [10, 11]}}
{"token": ["T4/T8", "cell", "ratios", "were", "reversed", "in", "symptomatic", "C0085315#ent", "<e1>", "(", "0.7", "+", "/-", "0.3", ")", "and", "normal", "in", "C0151317#ent", "<e2>", "1.7", "+", "/-", "0.5", ")", "."], "h": {"id": "C0085315", "name": "C0085315#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0151317", "name": "C0151317#ent", "pos": [18, 19]}}
{"token": ["C0733398#ent", "<e1>", "and", "adrenalectomy", "eliminated", "the", "hindquarters", "pressor", "response", "to", "C1412228#ent", "<e2>", "and", "D-Phe2-VIP", ",", "a", "VIP", "antagonist", ",", "reduced", "responses", "to", "VIP", "but", "not", "to", "C1412228#ent", "<e2>", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [10, 11]}}
{"token": ["However", ",", "the", "failure", "of", "the", "C0040416#ent", "<e1>", "to", "react", "to", "a", "potent", "cholinesterase", "inhibitor", "C0057361#ent", "<e2>", "%", ")", "suggested", "an", "abnormality", "relative", "to", "acetylcholine", "production", "in", "the", "iris", "."], "h": {"id": "C0040416", "name": "C0040416#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0057361", "name": "C0057361#ent", "pos": [15, 16]}}
{"token": ["C0207647#ent", "<e1>", "was", "shown", "to", "improve", "the", "C0036442#ent", "<e2>", "at", "doses", "of", "25", "to", "100", "mg/kg", "p.o", "."], "h": {"id": "C0207647", "name": "C0207647#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036442", "name": "C0036442#ent", "pos": [7, 8]}}
{"token": ["Because", "atherogenic", "effects", "not", "be", "limited", "to", "proliferation", ",", "we", "decided", "to", "examine", "whether", "Neu3", "exerted", "inhibitory", "effects", "on", "C0623362#ent", "<e1>", "MMP-9", ")", "activity", "in", "C1710304#ent", "<e2>", "VSMC", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [25, 26]}}
{"token": ["Inhibiting", "Tdp1", "has", "the", "potential", "to", "enhance", "the", "anticancer", "activity", "of", "C0003015#ent", "<e1>", "http://discover.nci.nih.gov/pommier/pommier.htm", ")", "and", "to", "act", "as", "C0003392#ent", "<e2>"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [19, 20]}}
{"token": ["The", "C0341703#ent", "<e1>", "children", "with", "C2931187#ent", "<e2>", "plasma", "and", "muscle", "carnitine", "depletion", "."], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C2931187", "name": "C2931187#ent", "pos": [5, 6]}}
{"token": ["Here", "we", "investigate", "the", "function", "of", "histamine", "by", "immunohistochemical", "and", "behavioral", "analysis", "mutants", "deficient", "in", "the", "C1415505#ent", "<e1>", "codes", "for", "C0019605#ent", "<e2>"], "h": {"id": "C1415505", "name": "C1415505#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0019605", "name": "C0019605#ent", "pos": [20, 21]}}
{"token": ["were", "almost", "completely", "inhibited", "by", "treatment", "with", "C0080138#ent", "<e1>", "a", "selective", "C0178601#ent", "<e2>"], "h": {"id": "C0080138", "name": "C0080138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0178601", "name": "C0178601#ent", "pos": [11, 12]}}
{"token": ["C0080138#ent", "<e1>", ",", "a", "selective", "C0178601#ent", "<e2>", "and", "(-)-butaclamol", "did", "not", "alter", "basal", "cyclase", "activity", ",", "whereas", "dopamine", "increased", "enzyme", "activity", "membranes", "expressing", "the", "D(1A", ")", "dopamine", "receptor"], "h": {"id": "C0080138", "name": "C0080138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0178601", "name": "C0178601#ent", "pos": [5, 6]}}
{"token": ["A", "reduction", "in", "the", "reserved", "secretory", "capacity", "of", "cortisol", "after", "prolonged", "C0032950#ent", "<e1>", "treatment", "was", "considered", "to", "have", "induced", "C0271738#ent", "<e2>", "even", "after", "4", "years", "of", "total", "withdrawal", "from", "C0032950#ent", "<e1>", "."], "h": {"id": "C0271738", "name": "C0271738#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [11, 12]}}
{"token": ["Chromatin", "immunoprecipitation", "experiments", "that", "C0812258#ent", "<e1>", "and", "E2F4", "associate", "with", "the", "C1426147#ent", "<e2>", "promoter", "in", "unperturbed", "cells", "."], "h": {"id": "C0812258", "name": "C0812258#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1426147", "name": "C1426147#ent", "pos": [11, 12]}}
{"token": ["The", "C2936862#ent", "<e1>", "an", "autosomal", "recessive", "disorder", "polydactyly", ",", "obesity", ",", "C0035334#ent", "<e2>", "mental", "retardation", "hypogenitalism", ",", "and", "renal", "involvement", "."], "h": {"id": "C2936862", "name": "C2936862#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [11, 12]}}
{"token": ["Ambulatory", "blood", "pressure", "monitoring", "ABPM", ")", "provides", "superior", "information", "for", "diagnosis", "and", "treatment", "of", "C0020538#ent", "<e1>", "but", "for", "reasons", "of", "practicality", ",", "clinic", "blood", "pressure", "measurements", "C1337090#ent", "<e2>", ")", "are", "still", "the", "primary", "diagnostic", "tool", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1337090", "name": "C1337090#ent", "pos": [26, 27]}}
{"token": ["The", "objective", "of", "this", "randomised", ",", "nonblind", "study", "to", "assess", "the", "efficacy", "of", "C0015843#ent", "<e1>", "as", "complementary", "anti-inflammatory", "therapy", "combination", "with", "C0700580#ent", "<e2>", "patients", "with", "chronic", "bronchitis", "CB", ")", "."], "h": {"id": "C0015843", "name": "C0015843#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0700580", "name": "C0700580#ent", "pos": [21, 22]}}
{"token": ["C0114873#ent", "<e1>", "is", "a", "competitive", "inhibitor", "of", "norepinephrine", "at", "alpha", "1", "adrenoceptors", "C1412137#ent", "<e2>", "where", "it", "blocks", "vasoconstriction", "."], "h": {"id": "C0114873", "name": "C0114873#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [12, 13]}}
{"token": ["Ligation", "of", "the", "C0000294#ent", "<e1>", "in", "fat-tailed", "sheep", "induced", "a", "significant", "reduction", "in", "C0723176#ent", "<e2>", ",", "suggesting", "that", "the", "presence", "of", "tail", "fat", "affects", "halothane", "metabolism", "during", "the", "peri-anaesthetic", "period", "in", "sheep", "."], "h": {"id": "C0000294", "name": "C0000294#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0723176", "name": "C0723176#ent", "pos": [13, 14]}}
{"token": ["Among", "the", "four", "C0026794#ent", "<e1>", "SOD", "and", "C1422198#ent", "<e2>", "revealed", "best", "discriminating", "power", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1422198", "name": "C1422198#ent", "pos": [7, 8]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "evaluate", "the", "C0271408#ent", "<e1>", "penetration", "of", "two", "commercially", "available", "C0949665#ent", "<e2>", "ofloxacin", "and", "levofloxacin", "."], "h": {"id": "C0271408", "name": "C0271408#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0949665", "name": "C0949665#ent", "pos": [16, 17]}}
{"token": ["C3642322#ent", "<e1>", "which", "is", "encoded", "by", "the", "C1413078#ent", "<e2>", "is", "required", "for", "the", "first", "three", "rate-limiting", "steps", "of", "de", "novo", "pyrimidine", "biosynthesis"], "h": {"id": "C3642322", "name": "C3642322#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413078", "name": "C1413078#ent", "pos": [7, 8]}}
{"token": ["The", "patient", "suffered", "from", "recurrent", "C1457887#ent", "<e1>", "which", "were", "attributed", "to", "C0021847#ent", "<e2>", "DIOS", ")", "until", "a", "soft", "tissue", "inflammation", "at", "the", "right", "lumbar", "region", "iliac", "crest", "an", "enterosubcutaneous", "fistula"], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021847", "name": "C0021847#ent", "pos": [11, 12]}}
{"token": ["Alcohol", ",", "spices", "or", "drugs", "may", "produce", "a", "\"", "toxic", "damage", "of", "the", "mucosa", ",", "but", "they", "do", "not", "cause", "an", "C0149518#ent", "<e1>", "just", "as", "little", "as", "some", "C0042769#ent", "<e2>", "staphylococcal", "toxins"], "h": {"id": "C0149518", "name": "C0149518#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [28, 29]}}
{"token": ["Moreover", "C0021246#ent", "<e1>", "diminished", "the", "homocysteine", "effect", "C3853644#ent", "<e2>", ",", "p72syk", "and", "PLCgamma2", ",", "suggesting", "that", "thromboxane", "A(2)", "be", "involved", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3853644", "name": "C3853644#ent", "pos": [7, 8]}}
{"token": ["These", "data", "demonstrate", "that", "the", "C0356622#ent", "<e1>", "do", "not", "mediate", "the", "ability", "of", "captopril", "to", "increase", "C3274822#ent", "<e2>", "or", "effective", "renal", "plasma", "flow", "this", "experimental", "model"], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", ",", "we", "have", "used", "computational", "methods", "model", "the", "selectivity", "for", "six", "thiadiazole", "urea", "inhibitors", "with", "C0164371#ent", "<e1>", "and", "gelatinase-A", ",", "two", "C1334043#ent", "<e2>", "MMPs", "that", "have", "been", "implicated", "in", "breast", "cancer"], "h": {"id": "C0164371", "name": "C0164371#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [24, 25]}}
{"token": ["sCD40L", "failed", "to", "correlate", "significantly", "with", "C1705674#ent", "<e1>", "(", "p=0.264", ")", ",", "unlike", "%", "platelets", "C1705801#ent", "<e2>", "(", "p=0.0032", ")", "and", "CD63+ve", "(", "p=0.009", ")", "."], "h": {"id": "C1705674", "name": "C1705674#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705801", "name": "C1705801#ent", "pos": [15, 16]}}
{"token": ["A", "decreasing", "order", "of", "potency", "was", "obtained", "with", "C0700580#ent", "<e1>", ",", "scopolamine", ",", "atropine", ",", "trihexyphenidyl", ",", "C0002600#ent", "<e2>", ",", "and", "gallamine", ",", "both", "for", "pre-", "and", "postsynaptic", "responses"], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "LPA", "and", "ET-1", "treatment", "of", "PLCgamma1+/+", "and", "C1418640#ent", "<e1>", "not", "cause", "tyrosine", "phosphorylation", "C0136864#ent", "<e2>", "or", "PLC-gamma2", "."], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0136864", "name": "C0136864#ent", "pos": [15, 16]}}
{"token": ["We", "present", "the", "immunological", "studies", "2", "patients", ",", "one", "with", "the", "C0043194#ent", "<e1>", "another", "with", "common", "variable", "C0086438#ent", "<e2>", "."], "h": {"id": "C0043194", "name": "C0043194#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0086438", "name": "C0086438#ent", "pos": [17, 18]}}
{"token": ["This", "observation", "seems", "to", "indicate", "lesser", "contribution", "of", "C0010073#ent", "<e1>", "cancerous", "population", "justifies", "the", "discussion", "of", "possible", "significance", "of", "C1425284#ent", "<e2>", "(", "endothelium-derived", "relaxing", "factor", "and", "catecholamines", "."], "h": {"id": "C0010073", "name": "C0010073#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425284", "name": "C1425284#ent", "pos": [19, 20]}}
{"token": ["Their", "ability", "to", "induce", "lytic", "gene", "supports", "a", "role", "for", "phorbol-ester", "and", "proteasome-regulated", "signalling", "pathways", "in", "C3891713#ent", "<e1>", "reactivation", "and", "prompts", "further", "investigation", "of", "C0277794#ent", "<e2>", "and", "bortezomib", "as", "therapeutic", "agents", "KSHV-associated", "malignancies", "."], "h": {"id": "C3891713", "name": "C3891713#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0277794", "name": "C0277794#ent", "pos": [24, 25]}}
{"token": ["Most", ",", "if", "not", "all", ",", "of", "the", "C0268731#ent", "<e1>", "found", "to", "be", "firmly", "membrane-bound", ",", "whereas", "the", "C0671566#ent", "<e2>", "of", "the", "tubules", "was", "mainly", "soluble", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0671566", "name": "C0671566#ent", "pos": [18, 19]}}
{"token": ["beta", "2-Glycoprotein", "I", "beta", "2GI", ")", "was", "identified", "as", "a", "major", "urinary", "protein", "excreted", "by", "patients", "with", "several", "C0022658#ent", "<e1>", "including", "adult", "C0015624#ent", "<e2>", "nephrocalcinosis", "associated", "with", "autoimmune", "diseases", "Lowe's", "syndrome", "and", "Dent's", "disease", "a", "familial", "renal", "tubular", "disease", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [18, 19]}, "relation": "nichd_parent_of", "t": {"id": "C0015624", "name": "C0015624#ent", "pos": [22, 23]}}
{"token": ["Macrophage", "membranes", "incubated", "with", "different", "agents", "i.e.", "prostaglandin", "E2", "PGE2", ")", ",", "C1419071#ent", "<e1>", "PGI2", ")", ",", "isoprenalin", "(", "ISO", ")", "and", "sodium", "fluoride", "C0876942#ent", "<e2>", ")", "."], "h": {"id": "C1419071", "name": "C1419071#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0876942", "name": "C0876942#ent", "pos": [24, 25]}}
{"token": ["To", "report", "the", "efficacy", "of", "extracorporeal", "life", "support", "ECLS", ")", "in", "C0006949#ent", "<e1>", "sustained", "refractory", "C0018801#ent", "<e2>", "a", "high", "degree", "of", "conductance", "disturbances"], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [15, 16]}}
{"token": ["The", "apolipoprotein", "E4", "APOE4", ")", "allele", "is", "associated", "with", "early", "age", "of", "onset", "of", "the", "nonfamilial", "form", "of", "C0002395#ent", "<e1>", "AD", ")", "and", "with", "increased", "C2362547#ent", "<e2>", "deposition", "in", "the", "brain", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2362547", "name": "C2362547#ent", "pos": [25, 26]}}
{"token": ["The", "mean", "percentage", "increase", "of", "C0016424#ent", "<e1>", "and", "LH", "was", "higher", "the", "greater", "the", "severity", "of", "C0023890#ent", "<e2>"], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [16, 17]}}
{"token": ["We", "present", "a", "case", "of", "a", "young", "child", "developed", "eight-and-a-half", "C0039082#ent", "<e1>", "following", "a", "C0041295#ent", "<e2>", "an", "unusual", "complication", "of", "central", "nervous", "system", "tuberculosis", "not", "previously", "described", "in", "an", "immunocompetent", "child", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041295", "name": "C0041295#ent", "pos": [14, 15]}}
{"token": ["Here", "we", "described", "the", "characteristics", "of", "polyarthritis", "in", "C0079556#ent", "<e1>", "careers", ",", "which", "is", "indistinguishable", "from", "C0038013#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0079556", "name": "C0079556#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [16, 17]}}
{"token": ["However", ",", "recent", "studies", "have", "revealed", "that", "C0079556#ent", "<e1>", "may", "disrupt", "the", "immune", "system", "lead", "to", "the", "development", "of", "C0038013#ent", "<e2>", "Sj\u00f6gren", "syndrome"], "h": {"id": "C0079556", "name": "C0079556#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [19, 20]}}
{"token": ["We", "describe", "a", "54-year-old", "woman", "with", "long-standing", "C0038013#ent", "<e1>", "by", "Felty's", "syndrome", "lung", "involvement", "who", "developed", "C1527383#ent", "<e2>", "no", "features", "of", "systemic", "sclerosis"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1527383", "name": "C1527383#ent", "pos": [16, 17]}}
{"token": ["Counterparts", "of", "the", "rabbit", "C1421318#ent", "<e1>", "or", "its", "C0079429#ent", "<e2>", "are", "described", "in", "rat", ",", "mouse", ",", "hamster", ",", "hare", ",", "pig", ",", "horse", "and", "human", "."], "h": {"id": "C1421318", "name": "C1421318#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [8, 9]}}
{"token": ["In", "order", "to", "express", "C1421318#ent", "<e1>", "in", "Escherichia", "coli", "have", "constructed", "a", "DNA", "coding", "complete", "mature", "rabbit", "C1421318#ent", "<e1>", "by", "fusing", "genomic", "sequences", "the", "second", "exon", "of", "the", "C0079429#ent", "<e1>", "to", "an", "incomplete", "cDNA", "."], "h": {"id": "C1421318", "name": "C1421318#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [28, 29]}}
{"token": ["By", "applying", "fluorescence-activated", "cell", "sorting", "FACS", ")", "to", "quantify", "the", "cellular", "dimensions", "multiple", "C1705594#ent", "<e1>", "mutants", ",", "we", "found", "that", "the", "C0036734#ent", "<e2>", "PBP", "4", "C1705594#ent", "<e1>", "7", "also", "influence", "cell", "shape", "concert", "with", "C1705594#ent", "<e1>", "5", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1705594", "name": "C1705594#ent", "pos": [13, 14]}}
{"token": ["Murine", "C3542477#ent", "<e1>", "been", "shown", "to", "be", "C0033713#ent", "<e2>", "."], "h": {"id": "C3542477", "name": "C3542477#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033713", "name": "C0033713#ent", "pos": [7, 8]}}
{"token": ["Therefore", ",", "the", "blockade", "by", "cicletanine", "of", "histamine-enhanced", "phosphoinositide", "turnover", "may", "participate", "in", "the", "mechanism", "by", "which", "the", "C1254351#ent", "<e1>", "exerts", "its", "C1516018#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1516018", "name": "C1516018#ent", "pos": [22, 23]}}
{"token": ["Recessive", "mutations", "of", "C1413269#ent", "<e1>", "in", "early", "onset", "hyperphagia", ",", "morbid", "obesity", "C0025517#ent", "<e2>", "early", "mortality", "shortened", "life-span", "."], "h": {"id": "C1413269", "name": "C1413269#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [12, 13]}}
{"token": ["Potential", "target", "autoantigens", "in", "the", "demyelinating", "form", "of", "C0018378#ent", "<e1>", "GBS", ")", "include", "the", "myelin", "proteins", "PMP22", ",", "C1417248#ent", "<e2>", "and", "P2", "."], "h": {"id": "C0018378", "name": "C0018378#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417248", "name": "C1417248#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "the", "changes", "in", "the", "acidic", "and", "basic", "properties", "on", "the", "surface", "of", "C0287573#ent", "<e1>", "powder", "were", "investigated", "using", "IGC", "under", "various", "relative", "humidities", "C1785148#ent", "<e2>", ")", "."], "h": {"id": "C0287573", "name": "C0287573#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1785148", "name": "C1785148#ent", "pos": [25, 26]}}
{"token": ["We", "conclude", "that", "the", "dietary", "regulation", "C1367475#ent", "<e1>", "affinity", "in", "C0011860#ent", "<e2>", "abnormal", ",", "and", "insulin", "receptor", "affinity", "is", "regulated", "by", "factors", "other", "than", "insulin", "."], "h": {"id": "C1367475", "name": "C1367475#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [10, 11]}}
{"token": ["Her", "morphological", "features", "were", "a", "mask-like", "face", "limitation", "of", "horizontal", "eye", "movements", "severe", "C4082299#ent", "<e1>", "multiple", "and", "C0265213#ent", "<e2>", "the", "elbow", ",", "knee", ",", "and", "ankle", "joints", "and", "clubfeet", "."], "h": {"id": "C4082299", "name": "C4082299#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0265213", "name": "C0265213#ent", "pos": [17, 18]}}
{"token": ["Identified", "cell", "signaling", "have", "defined", "many", "potential", "mechanisms", "for", "initiating", "smooth", "muscle", "contraction", "with", "or", "without", "C1417547#ent", "<e1>", "RLC", ")", "phosphorylation", "by", "myosin", "light", "chain", "kinase", "C1706585#ent", "<e2>", ")", "."], "h": {"id": "C1417547", "name": "C1417547#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1706585", "name": "C1706585#ent", "pos": [26, 27]}}
{"token": ["The", "findings", "in", "the", "present", "study", "indicate", "that", "C0039832#ent", "<e1>", "caused", "a", "slight", "C0002871#ent", "<e2>", "and", "liver", "or", "kidney", "injury", "both", "levels", "tested", ",", "under", "these", "conditions", "."], "h": {"id": "C0039832", "name": "C0039832#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002871", "name": "C0002871#ent", "pos": [13, 14]}}
{"token": ["The", "causative", "agent", "TGEV", ")", "of", "porcine", "C0017162#ent", "<e1>", "to", "the", "C0010078#ent", "<e2>", ",", "a", "family", "of", "enveloped", "viruses", "a", "positive", ",", "single-stranded", "RNA", "genome", "."], "h": {"id": "C0017162", "name": "C0017162#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010078", "name": "C0010078#ent", "pos": [11, 12]}}
{"token": ["Removal", "of", "the", "Nup153-interacting", "region", "of", "C1427927#ent", "<e1>", "results", "in", "a", "significant", "change", "in", "the", "spectrum", "of", "C1539895#ent", "<e2>", "conjugates", "within", "the", "cell", "."], "h": {"id": "C1427927", "name": "C1427927#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539895", "name": "C1539895#ent", "pos": [17, 18]}}
{"token": ["A", "C0017337#ent", "<e1>", "involved", "in", "C1538164#ent", "<e2>", "DPH2", ",", "was", "cloned", "from", "Saccharomyces", "cerevisiae", "complementation", "of", "a", "diphthamide", "mutant", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538164", "name": "C1538164#ent", "pos": [5, 6]}}
{"token": ["Raltitrexed", ",", "pemetrexed", ",", "lometrexol", ",", "and", "C0299046#ent", "<e1>", "are", "antifolate", "drugs", "transported", "into", "cells", "via", "the", "ubiquitously", "expressed", "C1420117#ent", "<e2>"], "h": {"id": "C0299046", "name": "C0299046#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420117", "name": "C1420117#ent", "pos": [19, 20]}}
{"token": ["To", "evaluate", "the", "efficacy", "of", "C0025872#ent", "<e1>", "on", "cyclosporine-induced", "gingival", "overgrowth", "(", "C1822658#ent", "<e2>", ")", ",", "a", "prospective", "intra-subject", "double-blind", "longitudinal", "study", "performed", "on", "six", "heart", "transplant", "patients", "with", "C1822658#ent", "<e2>", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1822658", "name": "C1822658#ent", "pos": [12, 13]}}
{"token": ["The", "parameter", "evaluated", "was", "the", "latency", "between", "the", "contraction", "of", "C0524890#ent", "<e1>", "and", "the", "prime", "mover", "the", "C0030196#ent", "<e2>", "."], "h": {"id": "C0524890", "name": "C0524890#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [17, 18]}}
{"token": ["Incubation", "of", "dephosphorylated", "outer", "membranes", "with", "protein", "kinases", "[gamma-32P]ATP", "resulted", "in", "radiolabeling", "of", "C0342790#ent", "<e1>", "only", "by", "C1707154#ent", "<e2>", "."], "h": {"id": "C0342790", "name": "C0342790#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1707154", "name": "C1707154#ent", "pos": [17, 18]}}
{"token": ["Eight", "C0242994#ent", "<e1>", "and", "desferrioxamine", "(", "DFO", ")", ",", "the", "C0013227#ent", "<e2>", "currently", "used", "to", "treat", "Al", "intoxication", ",", "were", "studied", "."], "h": {"id": "C0242994", "name": "C0242994#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [10, 11]}}
{"token": ["These", "data", "demonstrate", "that", "C2983365#ent", "<e1>", "signaling", "is", "dispensable", "to", "raise", "an", "acquired", "immune", "response", "C1826313#ent", "<e2>", "."], "h": {"id": "C2983365", "name": "C2983365#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1826313", "name": "C1826313#ent", "pos": [15, 16]}}
{"token": ["In", "contrast", ",", "infection", "by", "live", ",", "virulent", "Mycobacterium", "tuberculosis", "C1826313#ent", "<e1>", ")", "activated", "macrophages", "largely", "through", "MyD88-independent", "pathways", "and", "macrophages", "did", "not", "need", "C2983365#ent", "<e2>", "to", "kill", "C1826313#ent", "<e1>", "in", "vitro"], "h": {"id": "C2983365", "name": "C2983365#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1826313", "name": "C1826313#ent", "pos": [10, 11]}}
{"token": ["Gip2", "and", "v-Src", "activated", "C1434639#ent", "<e1>", "in", "transfected", "Rat", "1a", "cells", ",", "whereas", "C0949794#ent", "<e2>", "activated", "C1434639#ent", "<e1>", "in", "transfected", "NIH3T3", "cells", "."], "h": {"id": "C1434639", "name": "C1434639#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0949794", "name": "C0949794#ent", "pos": [13, 14]}}
{"token": ["When", "C0297666#ent", "<e1>", ",", "a", "p38MAPK", "inhibitor", "was", "added", ",", "C1367028#ent", "<e2>", "mRNA", "and", "RANKL", "protein", "expression", "were", "increased", "in", "these", "cells", "."], "h": {"id": "C0297666", "name": "C0297666#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367028", "name": "C1367028#ent", "pos": [10, 11]}}
{"token": ["Recently", ",", "connection", "between", "this", "termolabile", "mutation", "of", "the", "C0066357#ent", "<e1>", "numerous", "conditions", "and", "C0029896#ent", "<e2>", "has", "been", "established", "."], "h": {"id": "C0066357", "name": "C0066357#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}}
{"token": ["Our", "observation", "suggests", "that", "C0027697#ent", "<e1>", "hypoalbuminemia", "is", "a", "major", "risk", "factor", "severe", "pulmonary", "hemorrhage", "C0024141#ent", "<e2>", "patients", "and", "that", "high", "dose", "corticosteroid", "use", "can", "not", "prevent", "the", "occurrence", "of", "severe", "pulmonary", "hemorrhage", "C0024141#ent", "<e2>", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "cilnidipine", "may", "serve", "as", "a", "useful", "antihypertensive", "medication", "the", "treatment", "of", "C0235222#ent", "<e1>", "and", "also", "attenuate", "the", "white-coat", "effect", "in", "patients", "with", "C0155583#ent", "<e2>"], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0155583", "name": "C0155583#ent", "pos": [26, 27]}}
{"token": ["Clinical", "manifestations", "C0018681#ent", "<e1>", "with", "visual", "and", "C0018050#ent", "<e2>", "impotence", ",", "infertiligy", ",", "and", "gynecomastia", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [7, 8]}}
{"token": ["Our", "results", "demonstrate", "that", "IR", "is", "a", "new", "target", "gene", "of", "C1706243#ent", "<e1>", ",", "and", "support", "a", "potential", "use", "of", "TZDs", "as", "C0003392#ent", "<e2>", "selected", "neoplastic", "tissues", "overexpressing", "IRs", "."], "h": {"id": "C1706243", "name": "C1706243#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [22, 23]}}
{"token": ["In", "view", "of", "this", "similarity", "with", "amyotrophic", "lateral", "sclerosis", "C0154682#ent", "<e1>", "represent", "a", "slowly", "progressive", "syndrome", "closely", "related", "to", "C0085084#ent", "<e2>", "amyotrophic", "lateral", "sclerosis"], "h": {"id": "C0154682", "name": "C0154682#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [19, 20]}}
{"token": ["Motor", "neurone", "disease", "or", "amyotrophic", "lateral", "sclerosis", "is", "a", "serious", "progressive", "C0027765#ent", "<e1>", "characterized", "by", "loss", "of", "UMN", "and", "C1705895#ent", "<e2>", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705895", "name": "C1705895#ent", "pos": [19, 20]}}
{"token": ["Multiple", "resistances", "C0003207#ent", "<e1>", "in", "Escherichia", "coli", "isolates", "may", "complicate", "therapeutic", "management", "C0262655#ent", "<e2>", "UTI", ")", "by", "this", "organism", "."], "h": {"id": "C0003207", "name": "C0003207#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0262655", "name": "C0262655#ent", "pos": [12, 13]}}
{"token": ["A", "variety", "of", "pending", "new", "therapies", "are", "briefly", "presented", "including", "C0003209#ent", "<e1>", "protease", "inhibitors", "ion", "transport", "inhibitors", "antiviscosity", "agents", ",", "C1413451#ent", "<e2>", "modifiers", ",", "and", "immunomodifiers", "."], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413451", "name": "C1413451#ent", "pos": [20, 21]}}
{"token": ["Tau", "levels", "did", "not", "allow", "differential", "diagnosis", "of", "dementia", "type", "for", "C2347435#ent", "<e1>", ",", "where", "we", "observed", "extremely", "high", "C3889436#ent", "<e2>", "levels", "."], "h": {"id": "C2347435", "name": "C2347435#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3889436", "name": "C3889436#ent", "pos": [19, 20]}}
{"token": ["Cystinosis", "is", "a", "C0019247#ent", "<e1>", "by", "a", "C0043208#ent", "<e2>", "cystine", "in", "most", "tissues", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0043208", "name": "C0043208#ent", "pos": [7, 8]}}
{"token": ["Phosphatidylinositol", "3-kinase", "C0173879#ent", "<e1>", "and", "p70", "kinase", "inhibited", "with", "C0251991#ent", "<e2>", ",", "PD98059", ",", "and", "rapamycin", ",", "respectively", "."], "h": {"id": "C0173879", "name": "C0173879#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0251991", "name": "C0251991#ent", "pos": [9, 10]}}
{"token": ["The", "more", "important", "food-borne", "diseases", "Singapore", "are", "food", "poisoning", "C0015967#ent", "<e1>", "cholera", "and", "hepatitis", "A.", "Bacterial", "food", "poisoning", "by", "Staphylococcus", "aureus", "C0036117#ent", "<e2>", "and", "Vibrio", "parahaemolyticus", "prevalent", ",", "but", "chemical", "poisoning", "to", "ingestion", "of", "toxic", "plants", "animals", "is", "uncommon", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0036117", "name": "C0036117#ent", "pos": [21, 22]}}
{"token": ["Several", "recent", "studies", "indicate", "that", "type", "2", "diabetes", "C0020538#ent", "<e1>", "lipid", "disorders", "well", "as", "C2936179#ent", "<e2>", "coronary", "risk", "factors", "might", "belong", "to", "a", "syndrome", "which", "is", "caused", "by", "decreased", "insulin", "sensitivity", "with", "compensatory", "hyperinsulinaemia", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2936179", "name": "C2936179#ent", "pos": [14, 15]}}
{"token": ["This", "inhibitory", "effect", "of", "C0795864#ent", "<e1>", "was", "not", "seen", "in", "tissue", "pretreated", "with", "C0043167#ent", "<e2>"], "h": {"id": "C0795864", "name": "C0795864#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [13, 14]}}
{"token": ["Individuals", "with", "C0016053#ent", "<e1>", "(", "FM", ")", "and/or", "chronic", "fatigue", "syndrome", "CFS", ")", "report", "C0003862#ent", "<e2>", "and", "myalgias", "."], "h": {"id": "C0016053", "name": "C0016053#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003862", "name": "C0003862#ent", "pos": [14, 15]}}
{"token": ["Coexposure", "to", "TRAIL/Apo2L", "and", "cytotoxic", "drugs", "as", "topotecan", ",", "C0023972#ent", "<e1>", "(", "1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea", ",", "CCNU", ")", "or", "C0076080#ent", "<e2>", "resulted", "in", "synergistic", "killing"], "h": {"id": "C0023972", "name": "C0023972#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0076080", "name": "C0076080#ent", "pos": [17, 18]}}
{"token": ["With", "enzyme-linked", "immunosorbent", "assays", "we", "found", "more", "PLAP", "in", "synovial", "fluid", "specimens", "from", "patients", "with", "rheumatoid", "arthritis", "with", "samples", "from", "patients", "with", "other", "C0003864#ent", "<e1>", "well", "as", "C0949690#ent", "<e2>", ",", "a", "noninflammatory", "arthropathy"], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [23, 24]}, "relation": "nichd_parent_of", "t": {"id": "C0949690", "name": "C0949690#ent", "pos": [27, 28]}}
{"token": ["These", "five", "isolated", "alkaloids", "were", "examined", "for", "C0003449#ent", "<e1>", "guinea", "pig", "after", "cough", "induction", "C1171556#ent", "<e2>", "stimulation", "."], "h": {"id": "C0003449", "name": "C0003449#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1171556", "name": "C1171556#ent", "pos": [14, 15]}}
{"token": ["Tissue", "distribution", "analysis", "C4085183#ent", "<e1>", "by", "HPLC", "showed", "an", "increase", "in", "concentration", "of", "the", "C1254351#ent", "<e2>", "in", "lung", "for", "both", "free", "and", "liposomal", "Amp-B", "in", "infected", "animals", "as", "compared", "to", "normal", "."], "h": {"id": "C4085183", "name": "C4085183#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [14, 15]}}
{"token": ["The", "aim", "of", "this", "work", "was", "to", "investigate", "the", "effects", "of", "C0815017#ent", "<e1>", "on", "the", "contraction", "induced", "by", "C2698414#ent", "<e2>", "and", "other", "vasoconstrictors", "in", "isolated", "human", "internal", "mammary", "artery", "IMA", ")", "preparations", "."], "h": {"id": "C0815017", "name": "C0815017#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [18, 19]}}
{"token": ["The", "C0032143#ent", "<e1>", "uPA", "was", "significantly", "decreased", "by", "doxycycline", "indicating", "an", "C0919336#ent", "<e2>", "inhibiting", "mechanism", "including", "the", "plasminogen/plasmin", "system"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [11, 12]}}
{"token": ["In", "summary", ",", "our", "data", "suggest", "that", "14", "-", "3", "-", "3", "interacts", "with", "phosphoserine", "residues", "the", "COOH", "terminus", "of", "the", "C1334088#ent", "<e1>", "and", "within", "the", "central", "domain", "C1704984#ent", "<e2>", "."], "h": {"id": "C1334088", "name": "C1334088#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1704984", "name": "C1704984#ent", "pos": [28, 29]}}
{"token": ["We", "conclude", "that", "the", "initial", "burst", "of", "Src", "activity", "required", "for", "efficient", "tyrosine", "phosphorylation", "C3640117#ent", "<e1>", "as", "PLCgamma", ",", "RasGAP", ",", "C1705297#ent", "<e2>", ",", "and", "SHP-2", "and", "for", "maximal", "activation", "of", "Erk", "."], "h": {"id": "C3640117", "name": "C3640117#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705297", "name": "C1705297#ent", "pos": [21, 22]}}
{"token": ["Propanediol", "oxidoreductase", "41.7", "%", "identity", "with", "the", "C0001942#ent", "<e1>", "Zymomonas", "mobilis", "39.5", "%", "identity", "with", "C1412238#ent", "<e2>", "from", "Saccharomyces", "cerevisiae"], "h": {"id": "C0001942", "name": "C0001942#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412238", "name": "C1412238#ent", "pos": [15, 16]}}
{"token": ["The", "series", "included", "non-inflammatory", "diseases", "as", "epilepsy", ",", "C1862939#ent", "<e1>", "and", "polyneuropathy", ";", "and", "inflammatory", "diseases", "as", "C0026769#ent", "<e2>", "neurolues", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [17, 18]}}
{"token": ["The", "primary", "role", "of", "imaging", "in", "C1862939#ent", "<e1>", "to", "exclude", "other", "causes", "such", "as", "cervical", "degenerative", "disk", "disease", "Chiari", "malformation", "C0026769#ent", "<e2>"], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [20, 21]}}
{"token": ["According", "to", "Hille", "'s", "modulated", "receptor", "hypothesis", ",", "C0005059#ent", "<e1>", "shares", "a", "common", "receptor", "with", "all", "other", "C3541403#ent", "<e2>", "LAs", ")", "in", "the", "voltage-gated", "Na+", "channel"], "h": {"id": "C0005059", "name": "C0005059#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3541403", "name": "C3541403#ent", "pos": [17, 18]}}
{"token": ["The", "pharmacodynamic", "interaction", "between", "retinol", "and", "C0048060#ent", "<e1>", "has", "been", "investigated", "in", "29", "fresh", "C1875400#ent", "<e2>", "of", "Plasmodium", "falciparum"], "h": {"id": "C0048060", "name": "C0048060#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [14, 15]}}
{"token": ["The", "clinical", "differentiation", "Parkinson's", "disease", "the", "C0270733#ent", "<e1>", "SND", ")", "type", "of", "multiple", "system", "atrophy", "MSA", ")", "and", "C0038868#ent", "<e2>", "SRO", ")", "may", "be", "difficult", "."], "h": {"id": "C0270733", "name": "C0270733#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038868", "name": "C0038868#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", "we", "use", "surface-enhanced", "Raman", "spectroscopy", "(", "C1425041#ent", "<e1>", ")", "to", "characterize", "the", "adsorption", "of", "C3273879#ent", "<e2>", "colloidal", "gold"], "h": {"id": "C1425041", "name": "C1425041#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3273879", "name": "C3273879#ent", "pos": [17, 18]}}
{"token": ["Recently", "we", "cloned", "the", "C1707866#ent", "<e1>", "the", "Saccharomyces", "cerevisiae", "homolog", "human", "CSB/ERCC6", ",", "a", "C0017337#ent", "<e2>", "involved", "in", "transcription-coupled", "repair", "the", "disorder", "Cockayne", "syndrome"], "h": {"id": "C1707866", "name": "C1707866#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [14, 15]}}
{"token": ["To", "understand", "the", "breadth", "of", "functions", "in", "which", "C1707866#ent", "<e1>", ",", "the", "transcriptional", "organization", "predicted", "products", "of", "two", "such", "C0017337#ent", "<e2>", "previously", "identified", "in", "a", "screen", "for", "sigmaB-dependent", "lacZ", "fusions", "were", "analysed", "."], "h": {"id": "C1707866", "name": "C1707866#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["We", "suggest", "that", "NAC", "can", "perpetuate", "the", "redox", "cycle", "between", "the", "quinone", "and", "the", "semiquinone", "forms", "of", "the", "C0046200#ent", "<e1>", ",", "thereby", "enhancing", "the", "production", "of", "C0289313#ent", "<e2>", "."], "h": {"id": "C0046200", "name": "C0046200#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [26, 27]}}
{"token": ["We", "have", "sequenced", "the", "penicillin-binding", "domain", "C2698695#ent", "<e1>", "penicillin-resistant", "South", "African", "pneumococcal", "isolates", "and", "have", "identified", "C2917660#ent", "<e2>", "substitutions", "which", "are", "common", "to", "all", "the", "resistant", "isolates", "analyzed", "."], "h": {"id": "C2698695", "name": "C2698695#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [16, 17]}}
{"token": ["Site-directed", "mutagenesis", "the", "C2698695#ent", "<e1>", "from", "isolate", "8303", "was", "then", "used", "to", "reverse", "particular", "C2917660#ent", "<e2>", "substitutions", ",", "followed", "by", "transformation", "of", "PBP", "2X/2B-R6", "transformants", "with", "the", "mutagenized", "C2698695#ent", "<e1>", "DNA", "."], "h": {"id": "C2698695", "name": "C2698695#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [14, 15]}}
{"token": ["Differences", "between", "albumin", "and", "lactated", "Ringer's", "solution", "between", "the", "C0206141#ent", "<e1>", "and", "lactated", "C1875730#ent", "<e2>", "groups", "were", "significant", "(", "p", "less", "than", "0.02", "and", "p", "less", "than", "0.05", ")", "."], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1875730", "name": "C1875730#ent", "pos": [13, 14]}}
{"token": ["In", "a", "blinded", "in", "vitro", "study", ",", "we", "compared", "the", "effects", "on", "hemostasis", "of", "a", "new", "C0206141#ent", "<e1>", ",", "prepared", "in", "a", "balanced", "solution", "with", "a", "conventional", "C0206141#ent", "<e1>", "preparation", "and", "C1875730#ent", "<e1>", "lactate", "solution"], "h": {"id": "C0206141", "name": "C0206141#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1875730", "name": "C1875730#ent", "pos": [31, 32]}}
{"token": ["In", "addition", "to", "the", "established", ",", "but", "restricted", ",", "efficacy", "of", "C0001046#ent", "<e1>", "attempts", "are", "being", "made", "to", "develop", "C0035064#ent", "<e2>", "which", "will", "stimulate", "muscarinic", "receptors", "."], "h": {"id": "C0001046", "name": "C0001046#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [19, 20]}}
{"token": ["Glucose", "transporter", "1", "GLUT-1", ")", ",", "a", "downstream", "product", "of", "C1333897#ent", "<e1>", "activation", ",", "is", "C3890227#ent", "<e2>", "in", "a", "variety", "of", "human", "tumours", "."], "h": {"id": "C1333897", "name": "C1333897#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3890227", "name": "C3890227#ent", "pos": [15, 16]}}
{"token": ["Caspase-9", "was", "among", "several", "C1720986#ent", "<e1>", "activated", "by", "C0031669#ent", "<e2>", ",", "suggesting", "a", "potential", "contribution", "of", "the", "intrinsic", "apoptotic", "pathway", "mediating", "the", "response", "to", "C0031669#ent", "<e2>", "."], "h": {"id": "C1720986", "name": "C1720986#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031669", "name": "C0031669#ent", "pos": [8, 9]}}
{"token": ["One", "gene", "encoding", "C1540075#ent", "<e1>", "(", "glucocorticoid-induced", "leucine", "zipper", "protein", ",", "a", "putative", "C1425411#ent", "<e2>", "is", "rapidly", "down-regulated", "by", "estrogen", "in", "these", "cells", "."], "h": {"id": "C1540075", "name": "C1540075#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425411", "name": "C1425411#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "we", "found", "that", "indoline", "is", "aromatized", "by", "cytochrome", "P450", "P450", ")", "C3540790#ent", "<e1>", "to", "produce", "C0021236#ent", "<e2>", "through", "a", "novel", "dehydrogenation", "pathway"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0021236", "name": "C0021236#ent", "pos": [19, 20]}}
{"token": ["No", "significant", "of", "reactivity", "were", "observed", "between", "the", "C1517282#ent", "<e1>", "N-acetyl", "and", "N-glycolyl", ",", "in", "these", "C0017082#ent", "<e2>", "."], "h": {"id": "C1517282", "name": "C1517282#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017082", "name": "C0017082#ent", "pos": [16, 17]}}
{"token": ["One", "worker", "without", "C0038034#ent", "<e1>", "have", "had", "asymptomatic", "C0276728#ent", "<e2>"], "h": {"id": "C0038034", "name": "C0038034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0276728", "name": "C0276728#ent", "pos": [8, 9]}}
{"token": ["A", "clinical", "study", "performed", "on", "13", "children", "with", "infections", ",", "including", "6", "with", "C0006285#ent", "<e1>", "1", "each", "with", "C0001344#ent", "<e2>", "acute", "bronchitis", "sepsis", ",", "staphylococcal", "scalded", "skin", "syndrome", "urinary", "tract", "infection", "subcutaneous", "abscess", "furuncle", "."], "h": {"id": "C0006285", "name": "C0006285#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001344", "name": "C0001344#ent", "pos": [18, 19]}}
{"token": ["When", "used", "in", "conjunction", "with", "systemic", "antifungal", "agents", "such", "as", "nystatin", "or", "C0009074#ent", "<e1>", ",", "a", "significantly", "decreased", "incidence", "of", "clinical", "oral", "candidiasis", "C0036690#ent", "<e2>", "observed", "."], "h": {"id": "C0009074", "name": "C0009074#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [23, 24]}}
{"token": ["Muscle", "injury", "to", "the", "C0042769#ent", "<e1>", "rise", "to", "rhabdomyolysis", "with", "efflux", "of", "C1417048#ent", "<e2>", "from", "the", "muscles", ",", "causing", "renal", "failure"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417048", "name": "C1417048#ent", "pos": [12, 13]}}
{"token": ["Interestingly", ",", "the", "linoleate", "products", "not", "enhance", "the", "C1367721#ent", "<e1>", "mitogenic", "effect", "variant", "SHE", "cells", "had", "lost", "C0079427#ent", "<e2>"], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0079427", "name": "C0079427#ent", "pos": [17, 18]}}
{"token": ["C0000424#ent", "<e1>", "prevented", "these", "pharmacological", "actions", "induced", "by", "C1539327#ent", "<e2>", "without", "affecting", "responses", "to", "GABA", ",", "3-aminopropranesulphonic", "acid", "muscimol", ",", "baclofen", "or", "the", "twitch", "responses", "transmural", "stimulation", "."], "h": {"id": "C0000424", "name": "C0000424#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539327", "name": "C1539327#ent", "pos": [8, 9]}}
{"token": ["C0020809#ent", "<e1>", "present", "in", "92.1", "%", "while", "C0005220#ent", "<e2>", "was", "present", "in", "70", "%", "of", "transconjugants", "."], "h": {"id": "C0020809", "name": "C0020809#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005220", "name": "C0005220#ent", "pos": [7, 8]}}
{"token": ["Prucalopride", ",", "a", "full", "5HT(4", ")", "C0243192#ent", "<e1>", "that", "has", "been", "promising", "in", "C0401149#ent", "<e2>", "may", "also", "be", "limited", "by", "toxicity", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0401149", "name": "C0401149#ent", "pos": [13, 14]}}
{"token": ["The", "role", "of", "magnesium", "ions", "in", "the", "activation", "of", "NADPH", "oxidase", "been", "investigated", "using", "flavocytochrome", "b-245", "and", "either", "C3538760#ent", "<e1>", "mixtures", "of", "recombinant", "p40phox", ",", "p47phox", ",", "C1417609#ent", "<e2>", "and", "Rac2", "."], "h": {"id": "C3538760", "name": "C3538760#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417609", "name": "C1417609#ent", "pos": [27, 28]}}
{"token": ["To", "varying", "extents", ",", "these", "microorganisms", "cause", "such", "classical", "genital", "infections", "urethritis", ",", "C0014534#ent", "<e1>", "and", "prostatitis", "as", "well", "as", "C2314882#ent", "<e2>"], "h": {"id": "C0014534", "name": "C0014534#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2314882", "name": "C2314882#ent", "pos": [20, 21]}}
{"token": ["The", "caspase", "inhibitor", "acetyl-Asp-Glu-Val-Asp-aldehyde", "(", "Ac-DEVD-CHO", ")", "effectively", "inhibited", "JNK/SAPK", "activation", ",", "bcl-2", "phosphorylation", "and", "partially", "attenuated", "the", "C0812281#ent", "<e1>", "production", "induced", "by", "C0246415#ent", "<e2>", "."], "h": {"id": "C0812281", "name": "C0812281#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0246415", "name": "C0246415#ent", "pos": [23, 24]}}
{"token": ["Paradoxically", ",", "MgcRacGAP", ",", "a", "C2984553#ent", "<e1>", "associates", "during", "cytokinesis", "with", "ECT2", ",", "a", "guanine", "nucleotide", "exchange", "factor", "C0812234#ent", "<e2>", ",", "and", "the", "localization", "of", "ECT2", "to", "both", "the", "central", "spindle", "the", "contractile", "ring", "on", "MgcRacGAP", "."], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812234", "name": "C0812234#ent", "pos": [18, 19]}}
{"token": ["Gel", "mobility", "shift", "assays", "that", "nuclear", "factor", "binding", "this", "25-base", "pair", "region", "of", "C1704811#ent", "<e1>", "competed", "by", "C0812312#ent", "<e2>", ",", "but", "not", "NF-1", "or", "NF-kappaB", ",", "oligonucleotides", "."], "h": {"id": "C1704811", "name": "C1704811#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [17, 18]}}
{"token": ["We", "assessed", "the", "effect", "of", "candesartan", "on", "cause-specific", "mortality", "in", "patients", "enrolled", "in", "the", "Candesartan", "in", "C0018801#ent", "<e1>", "Assessment", "of", "Reduction", "in", "Mortality", "and", "morbidity", "(", "C0849759#ent", "<e2>", ")", "program", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0849759", "name": "C0849759#ent", "pos": [26, 27]}}
{"token": ["We", "have", "carried", "out", "a", "prospective", "economic", "analysis", "of", "the", "Candesartan", "in", "C0018801#ent", "<e1>", "Assessment", "of", "Reduction", "in", "Mortality", "and", "morbidity", "(", "C0849759#ent", "<e2>", ")", "programme", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0849759", "name": "C0849759#ent", "pos": [22, 23]}}
{"token": ["Replacement", "of", "C0024730#ent", "<e1>", "with", "sucrose", "decreases", "the", "binding", "of", "[(203)Hg]-p-chloromercuribenzenesulphonic", "acid", "(", "C0008249#ent", "<e2>", ")", "to", "Vicia", "faba", "leaf", "discs", "without", "epidermis", "."], "h": {"id": "C0024730", "name": "C0024730#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008249", "name": "C0008249#ent", "pos": [13, 14]}}
{"token": ["We", "demonstrated", "that", "C1095795#ent", "<e1>", "induced", "typical", "phase", "2", "genes", ":", "C1415097#ent", "<e2>", "GCLC", ")", "and", "glutathione-S-transferase", "subunit-P1", "GST-P1", ")", ",", "by", "real-time", "PCR"], "h": {"id": "C1095795", "name": "C1095795#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415097", "name": "C1415097#ent", "pos": [11, 12]}}
{"token": ["A", "47-yr-old", "woman", "presenting", "with", "high", "fever", "C0015230#ent", "<e1>", ",", "and", "melena", "was", "diagnosed", "with", "C0014060#ent", "<e2>", "from", "positive", "antinuclear", "antibodies", "anti-dsDNA", ",", "and", "low", "complement", "titers"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [15, 16]}}
{"token": ["We", "evaluated", "the", "effects", "of", "five", "C0991617#ent", "<e1>", "in", "transgenic", "mice", "the", "G93A", "Cu", ",", "Zn", "C0038838#ent", "<e2>", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [16, 17]}}
{"token": ["The", "most", "common", "C0037274#ent", "<e1>", "noted", "was", "acne", "vulgaris", "followed", "by", "eczema", ",", "C0549567#ent", "<e2>", "seborrheic", "dermatitis", "and", "alopecias", "."], "h": {"id": "C0037274", "name": "C0037274#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0549567", "name": "C0549567#ent", "pos": [13, 14]}}
{"token": ["Linkage", "of", "C1366767#ent", "<e1>", "to", "the", "C1336938#ent", "<e2>", "not", "detected", ",", "and", "vWF", "was", "ruled", "out", "as", "a", "candidate", "gene", "for", "C1366767#ent", "<e1>", "."], "h": {"id": "C1366767", "name": "C1366767#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [6, 7]}}
{"token": ["Dipteran", "C0017428#ent", "<e1>", "contain", "one", "C1420875#ent", "<e2>", "encodes", "one", "or", "two", "high-molecular", "weight", "isoforms", "(", "TmH", ")", "incorporating", "APPAEGA-rich", "sequences", ",", "specifically", "expressed", "in", "IFM", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420875", "name": "C1420875#ent", "pos": [5, 6]}}
{"token": ["Mononuclear", "cells", "patients", "with", "C0041296#ent", "<e1>", ",", "however", ",", "did", "not", "suppress", "the", "C3889643#ent", "<e2>", "responses", "of", "allogeneic", "normal", "mononuclear", "cells", "(", "P", "greater", "than", "0.02", ")", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3889643", "name": "C3889643#ent", "pos": [13, 14]}}
{"token": ["The", "use", "of", "the", "ABCA1-transporter", "inhibitors", "C0311907#ent", "<e1>", "sulfobromophthalein", "significantly", "inhibited", "C2985364#ent", "<e2>", "externalization", "."], "h": {"id": "C0311907", "name": "C0311907#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2985364", "name": "C2985364#ent", "pos": [11, 12]}}
{"token": ["C1801950#ent", "<e1>", "a", "malformation", "syndrome", "the", "ventral", "midline", "characterized", "by", "hypertelorism", ",", "C0011168#ent", "<e2>", "hypospadias", "and", "developmental", "delay"], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [12, 13]}}
{"token": ["Three", "families", "including", "five", "subjects", "with", "the", "G", "or", "C1801950#ent", "<e1>", "added", "to", "23", "published", "cases", "had", "C0011168#ent", "<e2>", ";", "characteristics", "of", "the", "two", "affected", "relatives", "were", "added", "to", "19", "well", "documented", "published", "reports"], "h": {"id": "C1801950", "name": "C1801950#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0011168", "name": "C0011168#ent", "pos": [17, 18]}}
{"token": ["The", "C0242417#ent", "<e1>", "is", "further", "characterized", "by", "electron", "paramagnetic", "resonance", "C1366515#ent", "<e2>", ")", ",", "circular", "dichroism", "CD", ")", "and", "magnetic", "circular", "dichroism", "MCD", ")", "spectroscopy", "."], "h": {"id": "C0242417", "name": "C0242417#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1366515", "name": "C1366515#ent", "pos": [10, 11]}}
{"token": ["Measurement", "of", "peroxide", "production", "in", "regions", "normally", "displaying", "induction", "of", "HSP70", "under", "hyperthermia", "revealed", "high", "levels", "of", "C3539984#ent", "<e1>", "in", "normal", "mice", "low", "levels", "in", "C3811116#ent", "<e2>", "transgenic", "mice"], "h": {"id": "C3539984", "name": "C3539984#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3811116", "name": "C3811116#ent", "pos": [25, 26]}}
{"token": ["A", "case", "is", "described", "of", "C0017921#ent", "<e1>", "with", "an", "isolated", "rise", "in", "C0004002#ent", "<e2>", "."], "h": {"id": "C0017921", "name": "C0017921#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004002", "name": "C0004002#ent", "pos": [12, 13]}}
{"token": ["In", "dissociated", "rat", "cerebrocortical", "cell", "cultures", "long-term", "treatment", "with", "C0002555#ent", "<e1>", "(", "10", "-", "1000", "microM", ")", "attenuated", "C0022614#ent", "<e2>", "receptor-mediated", "glutamate", "cytotoxicity", "but", "produced", "no", "significant", "on", "glutamate-induced", "increases", "in", "intracellular", "Ca2", "+", "."], "h": {"id": "C0002555", "name": "C0002555#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [18, 19]}}
{"token": ["C0751951#ent", "<e1>", "patients", "present", "with", "C0746674#ent", "<e2>", "are", "also", "at", "risk", "of", "MH", "."], "h": {"id": "C0751951", "name": "C0751951#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0746674", "name": "C0746674#ent", "pos": [5, 6]}}
{"token": ["Paroxysmal", "cold", "hemoglobinuria", "a", "rare", "and", "potentially", "life-threatening", "acquired", "C0002878#ent", "<e1>", "either", "as", "an", "acute", "transient", "anemia", "following", "several", "different", "C0042740#ent", "<e2>", "or", "in", "a", "chronic", "idiopathic", "form"], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042740", "name": "C0042740#ent", "pos": [20, 21]}}
{"token": ["This", "study", "focused", "on", "the", "investigation", "of", "PON1", ",", "arylesterase", "and", "C0008429#ent", "<e1>", "activities", "in", "28", "acute", "C0338271#ent", "<e2>", "insecticide", "poisoning", "cases", "."], "h": {"id": "C0008429", "name": "C0008429#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0338271", "name": "C0338271#ent", "pos": [17, 18]}}
{"token": ["In", "hereditary", "hemochromatosis", "length", "C1384665#ent", "<e1>", "was", "the", "predominant", "C0597298#ent", "<e2>", "present", "in", "the", "duodenum", "similar", "to", "iron", "deficiency"], "h": {"id": "C1384665", "name": "C1384665#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [9, 10]}}
{"token": ["Although", "neuropsychological", "symptoms", "associated", "with", "multiple", "system", "atrophy", "MSA", ")", ",", "sporadic", "olivopontocerebellar", "atrophy", "C0752120#ent", "<e1>", ")", ",", "and", "dominantly", "inherited", "C0028968#ent", "<e2>", "dOPCA", ")", ",", "the", "differences", "between", "these", "groups", "have", "not", "been", "explored", "."], "h": {"id": "C0752120", "name": "C0752120#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0028968", "name": "C0028968#ent", "pos": [21, 22]}}
{"token": ["Both", "crude", "extracts", "homogeneous", "GS1", "and", "C3890009#ent", "<e1>", "preparations", "required", "divalent", "metal", "ions", "C1333909#ent", "<e2>", "+", ",", "Mn2", "+", ",", "Co2", "+", ")", "for", "their", "activities", "."], "h": {"id": "C3890009", "name": "C3890009#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333909", "name": "C1333909#ent", "pos": [13, 14]}}
{"token": ["To", "test", "the", "tolerability", "of", "long-term", "administration", "of", "C0053091#ent", "<e1>", "in", "dogs", "with", "C0018802#ent", "<e2>", "CHF", ")", "."], "h": {"id": "C0053091", "name": "C0053091#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["In", "the", "kidney", ",", "C0538927#ent", "<e1>", "can", "result", "in", "glomerular", "and", "C0041349#ent", "<e2>", "papillary", "necrosis"], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041349", "name": "C0041349#ent", "pos": [11, 12]}}
{"token": ["C1704693#ent", "<e1>", "also", "inhibited", "LPS-activated", "murine", "iNOS", "and", "C1705323#ent", "<e2>", "promoter", "activities", "transiently", "transfected", "RAW264.7", "cells", "."], "h": {"id": "C1704693", "name": "C1704693#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705323", "name": "C1705323#ent", "pos": [8, 9]}}
{"token": ["The", "C0302809#ent", "<e1>", "course", "of", "C0019340#ent", "<e2>", "the", "newborn", "and", "the", "generalized", "herpes", "infection", "the", "immunodeficient", "patient", "can", "be", "treated", "only", "with", "difficulty", "."], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0019340", "name": "C0019340#ent", "pos": [5, 6]}}
{"token": ["These", "proteins", "bind", "to", "a", "membrane", "receptor", "complex", "of", "a", "frizzled", "(", "FZD", ")", "G-protein-coupled", "receptor", "(", "C3890198#ent", "<e1>", ")", "and", "a", "low-density", "lipoprotein", "LDL", ")", "receptor-related", "protein", "C1417509#ent", "<e2>", ")", "."], "h": {"id": "C3890198", "name": "C3890198#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417509", "name": "C1417509#ent", "pos": [28, 29]}}
{"token": ["The", "relations", "between", "C0042109#ent", "<e1>", "and", "various", "diseases", "of", "the", "gastrointestinal", "tract", "C1418224#ent", "<e2>", ")", "are", "under", "discussion", "."], "h": {"id": "C0042109", "name": "C0042109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418224", "name": "C1418224#ent", "pos": [12, 13]}}
{"token": ["The", "dual", "regulatory", "role", "of", "ET-1", "consist", "on", "stimulation", "of", "collagen", "I", "III", "synthesis", "simultaneously", "on", "inhibition", "of", "C2001899#ent", "<e1>", "expression", "through", "inhibition", "of", "tissue", "inhibitors", "C1334706#ent", "<e2>", ":", "TIMP-1", "and", "TIMP-3", "."], "h": {"id": "C2001899", "name": "C2001899#ent", "pos": [18, 19]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334706", "name": "C1334706#ent", "pos": [26, 27]}}
{"token": ["TUCAN", "is", "expressed", "in", "the", "gut", "and", "is", "a", "negative", "regulator", "of", "C1417708#ent", "<e1>", ",", "making", "it", "an", "excellent", "candidate", "gene", "for", "C0017160#ent", "<e2>"], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017160", "name": "C0017160#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "whether", "interleukin", "1", "beta", "IL-1", "beta)", "5", "and", "IL-1", "receptor", "antagonist", "C1504688#ent", "<e1>", ")", "gene", "polymorphisms", "be", "used", "as", "markers", "of", "susceptibility", "to", "C0009952#ent", "<e2>", "convulsions", "in", "children", "."], "h": {"id": "C1504688", "name": "C1504688#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [25, 26]}}
{"token": ["The", "sequence", "data", "the", "NH2-terminal", "and", "seven", "internal", "peptides", "obtained", "by", "sequential", "digestions", "with", "Achromobacter", "protease", "I", "endoproteinase", "Asp-N", "that", "C1414110#ent", "<e1>", "a", "novel", "endonuclease", "that", "shows", "sequence", "homology", "with", "C0011522#ent", "<e2>", "I."], "h": {"id": "C1414110", "name": "C1414110#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [30, 31]}}
{"token": ["Reverse", "transcriptase-PCR", "analysis", "that", "the", "induction", "of", "C1414110#ent", "<e1>", "a", "member", "of", "the", "DNase", "I", "family", "of", "C0011522#ent", "<e2>", ",", "is", "correlated", "with", "the", "appearance", "of", "inducible", "DNase", "activity"], "h": {"id": "C1414110", "name": "C1414110#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [17, 18]}}
{"token": ["The", "C0029454#ent", "<e1>", "(", "op", ")", "mutation", "is", "within", "the", "C0017337#ent", "<e2>", "for", "macrophage", "colony-stimulating", "factor", "M-CSF", ")", "."], "h": {"id": "C0029454", "name": "C0029454#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["We", "have", "tested", "Galardin/GM6001", ",", "a", "potent", "C1417244#ent", "<e1>", "that", "reacts", "with", "most", "C0623362#ent", "<e2>", ",", "in", "the", "MMTV-PymT", "transgenic", "breast", "cancer", "model", "."], "h": {"id": "C1417244", "name": "C1417244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [13, 14]}}
{"token": ["The", "putative", "human", "and", "mouse", "C2698901#ent", "<e1>", "100", "%", "identical", ";", "the", "chicken", "C1439347#ent", "<e2>", "cDNA", "contains", "an", "open", "reading", "frame", "170", "amino", "acids", "a", "91", "%", "identity", "to", "its", "human", "and", "murine", "counterparts", "."], "h": {"id": "C2698901", "name": "C2698901#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1439347", "name": "C1439347#ent", "pos": [13, 14]}}
{"token": ["Compound-related", "nonneoplastic", "lesions", "included", "basal", "cell", "C0014599#ent", "<e1>", "the", "forestomach", "(", "rats", "and", "mice", ")", ",", "C0014599#ent", "<e1>", "the", "urinary", "bladder", "mice", ")", ",", "and", "C0020295#ent", "<e1>", "mice", ")", "."], "h": {"id": "C0014599", "name": "C0014599#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020295", "name": "C0020295#ent", "pos": [25, 26]}}
{"token": ["The", "combination", "of", "poor", "growth", "parathyroid", "and", "C0003462#ent", "<e1>", "the", "diagnosis", "of", "renal", "bone", "disease", "children", "with", "C0403447#ent", "<e2>", "CRI", ")", ",", "and", "the", "role", "of", "dual", "X-ray", "absorptiometry", "DXA", ")", "is", "unclear", "."], "h": {"id": "C0003462", "name": "C0003462#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0403447", "name": "C0403447#ent", "pos": [17, 18]}}
{"token": ["To", "perform", "a", "clinical", "and", "molecular", "study", "a", "large", "autosomal", "dominant", "family", "with", "a", "complex", "C0751911#ent", "<e1>", "comprises", "early-onset", "dementia", ",", "C0015371#ent", "<e2>", "and", "cerebellar", "features", ",", "and", "epilepsy", "."], "h": {"id": "C0751911", "name": "C0751911#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [21, 22]}}
{"token": ["Between", "September", "1987", "and", "January", "1989", "101", "drug", "users", "The", "C0085593#ent", "<e1>", "were", "studied", "for", "C0019693#ent", "<e2>", "seroprevalence", "and", "risky", "injecting", "behaviour", "."], "h": {"id": "C0085593", "name": "C0085593#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [15, 16]}}
{"token": ["We", "present", "a", "case", "of", "delirium", "due", "to", "C0002600#ent", "<e1>", "overdose", ",", "which", "resolved", "rapidly", "following", "initiation", "of", "the", "C3536756#ent", "<e2>", "donepezil", "."], "h": {"id": "C0002600", "name": "C0002600#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536756", "name": "C3536756#ent", "pos": [19, 20]}}
{"token": ["The", "second", "has", "presented", "the", "same", "oedema", "of", "the", "four", "C0030196#ent", "<e1>", ",", "with", "myalgias", ",", "but", "also", "C1282916#ent", "<e2>", "histological", "fasciitis", "and", "eosinophilia", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1282916", "name": "C1282916#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "examined", "the", "susceptibility", "of", "neural", "cell", "lines", "human", "(", "OL", ")", "and", "rat", "(", "C1419009#ent", "<e1>", ")", "origins", "to", "C1175175#ent", "<e2>"], "h": {"id": "C1419009", "name": "C1419009#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1175175", "name": "C1175175#ent", "pos": [22, 23]}}
{"token": ["A", "prospective", "randomized", "study", "conducted", "to", "compare", "the", "C3536993#ent", "<e1>", "efficacy", "of", "metoclopramide", "(", "C4283801#ent", "<e2>", ")", "versus", "its", "recent", "derivative", "alizapride", "(", "ALZ", ")", "in", "patients", "undergoing", "cancer", "chemotherapy"], "h": {"id": "C3536993", "name": "C3536993#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4283801", "name": "C4283801#ent", "pos": [14, 15]}}
{"token": ["In", "this", "report", ",", "we", "describe", "the", "cloning", "and", "partial", "DNA", "sequence", "analysis", "the", "C0079429#ent", "<e1>", "encoding", "the", "alpha", "2/delta-subunits", ",", "C1413065#ent", "<e2>", ",", "and", "its", "localization", "on", "the", "proximal", "long", "arm", "of", "chromosome", "7q"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413065", "name": "C1413065#ent", "pos": [21, 22]}}
{"token": ["In", "this", "paper", ",", "the", "C0036023#ent", "<e1>", "process", "of", "okara", "fiber", "with", "pectinase", ",", "xylanase", "and", "C1260229#ent", "<e2>", "was", "investigated", "as", "a", "preliminary", "attempt", "to", "effectively", "utilize", "okara", "fiber", "."], "h": {"id": "C0036023", "name": "C0036023#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1260229", "name": "C1260229#ent", "pos": [16, 17]}}
{"token": ["In", "patients", "with", "hyperbilirubinemic", "C0023895#ent", "<e1>", "serum", "protein", "of", "the", "C0935929#ent", "<e2>", "glymidine", "is", "reduced", "considerably", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [10, 11]}}
{"token": ["A", "new", "ulcer", "appeared", "while", "the", "patient", "was", "being", "treated", "with", "C0064113#ent", "<e1>", ",", "and", "the", "C0079429#ent", "<e2>", "for", "16S", "rRNA", "Cellulosimicrobium", "cellulans", "amplified", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [16, 17]}}
{"token": ["Coexpression", "of", "C1413072#ent", "<e1>", "similarly", "enhanced", "C0314619#ent", "<e2>", "."], "h": {"id": "C1413072", "name": "C1413072#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0314619", "name": "C0314619#ent", "pos": [6, 7]}}
{"token": ["Cutaneous", "and", "C0009663#ent", "<e1>", "the", "most", "frequent", "C0042769#ent", "<e2>", "the", "skin", "."], "h": {"id": "C0009663", "name": "C0009663#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["C0108225#ent", "<e1>", "CM", ")", ",", "an", "C1418544#ent", "<e2>", "has", "been", "used", "clinically", "for", "the", "treatment", "of", "chronic", "pancreatitis", "Japan", "."], "h": {"id": "C0108225", "name": "C0108225#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418544", "name": "C1418544#ent", "pos": [6, 7]}}
{"token": ["In", "the", "present", "study", "we", "describe", "the", "expression", "of", "C0760292#ent", "<e1>", "(", "GPC-4", ")", ",", "belonging", "to", "the", "C1415194#ent", "<e2>", "in", "bone-marrow-stromal", "cells", "and", "haematopoietic-progenitor", "cells", "human", "and", "murine", "origin", "."], "h": {"id": "C0760292", "name": "C0760292#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415194", "name": "C1415194#ent", "pos": [18, 19]}}
{"token": ["The", "outward", "K+", "current", "increased", "by", "lowering", "the", "intracellular", "C2744579#ent", "<e1>", "concentration", "(", "0.5", "mM", ")", "was", "efficiently", "blocked", "by", "C0098450#ent", "<e2>", "when", "recording", "in", "the", "whole", "cell", "configuration", "the", "application", "of", "voltage", "ramps"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0098450", "name": "C0098450#ent", "pos": [20, 21]}}
{"token": ["In", "patients", "with", "C0018939#ent", "<e1>", "especially", ",", "leukemias", "and", "lymphomas", ",", "complicated", "C0004623#ent", "<e2>", "becomes", "serious", "."], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [12, 13]}}
{"token": ["Compared", "with", "the", "product", "from", "monolayer", "cultures", "C1413930#ent", "<e1>", "collagen", "gels", "a", "longer", "C0032594#ent", "<e2>", "is", "characterized", "by", "a", "larger", "proportion", "of", "disulphated", "and", "a", "smaller", "proportion", "of", "monosulphated", "glucuronic", "acid-containing", "disaccharides", "."], "h": {"id": "C1413930", "name": "C1413930#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [13, 14]}}
{"token": ["The", "RVD", "was", "suppressed", "by", "an", "ATP", "C0033993#ent", "<e1>", "enzyme", ",", "apyrase", ",", "or", "by", "a", "purinergic", "receptor", "antagonist", "C0038880#ent", "<e2>", "."], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [19, 20]}}
{"token": ["C0018013#ent", "<e1>", "is", "the", "C0747256#ent", "<e2>", "by", "the", "migration", "of", "an", "advanced", "third-stage", "larva", "of", "Gnathostoma", "spinigerum"], "h": {"id": "C0018013", "name": "C0018013#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0747256", "name": "C0747256#ent", "pos": [4, 5]}}
{"token": ["The", "objective", "of", "this", "report", "is", "to", "demonstrate", "that", "children", "with", "CRPS-I", "can", "have", "additional", "C0013363#ent", "<e1>", "to", "an", "underlying", "maternally", "inherited", "C0751651#ent", "<e2>", "an", "association", "not", "previously", "published", "."], "h": {"id": "C0013363", "name": "C0013363#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0751651", "name": "C0751651#ent", "pos": [22, 23]}}
{"token": ["There", "was", "no", "evidence", "of", "hypoparathyroidism", "or", "C0001623#ent", "<e1>", "females", "with", "C0677669#ent", "<e2>", "."], "h": {"id": "C0001623", "name": "C0001623#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0677669", "name": "C0677669#ent", "pos": [11, 12]}}
{"token": ["C1412469#ent", "<e1>", "apoA-II", ")", "is", "the", "second", "most", "abundant", "protein", "in", "C3711381#ent", "<e2>", "."], "h": {"id": "C1412469", "name": "C1412469#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3711381", "name": "C3711381#ent", "pos": [11, 12]}}
{"token": ["In", "this", "paper", "we", "describe", "the", "controlled", "C1422826#ent", "<e1>", "process", "at", "one", "institution", "that", "utilizes", "the", "C3811118#ent", "<e2>", "team", "to", "provide", "expert", "end-of-life", "care", "including", "comprehensive", "medical", "management", "family", "support"], "h": {"id": "C1422826", "name": "C1422826#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3811118", "name": "C3811118#ent", "pos": [16, 17]}}
{"token": ["ICF", "(", "Immunodeficiency", ",", "Centromeric", "instability", "and", "Facial", "anomalies", "C1848862#ent", "<e1>", "is", "a", "rare", "autosomal", "recessive", "disease", "by", "mutations", "in", "the", "C0012873#ent", "<e2>", "DNMT3B", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012873", "name": "C0012873#ent", "pos": [21, 22]}}
{"token": ["C1419874#ent", "<e1>", ",", "as", "assayed", "by", "radioimmunoassay", "or", "ability", "to", "stimulate", "C1414040#ent", "<e2>", "was", "not", "elevated", "in", "adrenal", "cytosol", "other", "subcellular", "fractions", "ACTH", "treatment", "."], "h": {"id": "C1419874", "name": "C1419874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414040", "name": "C1414040#ent", "pos": [11, 12]}}
{"token": ["Overall", ",", "the", "results", "presented", "here", "clarify", "the", "mechanism", "of", "C0234238#ent", "<e1>", "inhibition", "by", "CPT-11", "and", "detail", "the", "interaction", "of", "the", "C0013227#ent", "<e2>", "with", "the", "protein", "."], "h": {"id": "C0234238", "name": "C0234238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [21, 22]}}
{"token": ["C0037354#ent", "<e1>", "is", "a", "recently", "extinct", "human", "C0042769#ent", "<e2>", "which", "herd", "immunity", "rapidly", "waned", "."], "h": {"id": "C0037354", "name": "C0037354#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["Using", "a", "sensitive", "graphics", "method", "for", "protein", "comparison", "conserved", "structural", "features", "found", "in", "some", "of", "the", "C0016964#ent", "<e1>", "and", "other", "classes", "of", "C1333828#ent", "<e2>", ",", "resulting", "in", "the", "definition", "of", "five", "families", "."], "h": {"id": "C0016964", "name": "C0016964#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333828", "name": "C1333828#ent", "pos": [22, 23]}}
{"token": ["Onset", "and", "intensity", "of", "motor", "blockade", "similar", "with", "all", "C0991617#ent", "<e1>", ",", "but", "motor", "blockade", "of", "significantly", "shorter", "C2926735#ent", "<e2>", "with", "hyperbaric", "bupivacaine", "the", "other", "C0991617#ent", "<e1>", "(", "p", "less", "than", "0.0005", ")", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [9, 10]}}
{"token": ["Elevated", "serum", "IgE", "eosinophilic", "counts", "were", "found", "in", "patients", "with", "C0011615#ent", "<e1>", "and", "high", "serum", "and", "fibrinogen", "levels", "found", "in", "the", "C0151436#ent", "<e2>", "group", "."], "h": {"id": "C0011615", "name": "C0011615#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151436", "name": "C0151436#ent", "pos": [21, 22]}}
{"token": ["To", "examine", "the", "relationship", "between", "C2931384#ent", "<e1>", "C0004623#ent", "<e2>", "authors", "studied", "the", "serum", "of", "85", "cases", "of", "C2931384#ent", "<e1>", "the", "influence", "of", "Propionibacterium", "acnes", "P.", "acnes", ")", "infection", "on", "intracranial", "arteries", "rats", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2931384", "name": "C2931384#ent", "pos": [5, 6]}}
{"token": ["Elevated", "levels", "were", "found", "in", "93", "%", "of", "patients", "with", "C0026848#ent", "<e1>", "in", "54", "%", "with", "myasthenia", "gravis", "in", "50", "%", "with", "C0027868#ent", "<e2>"], "h": {"id": "C0026848", "name": "C0026848#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [22, 23]}}
{"token": ["C1417701#ent", "<e1>", "expression", "significantly", "increased", "C1705592#ent", "<e2>", "mRNA", "levels", "and", "protein", "secretion"], "h": {"id": "C1417701", "name": "C1417701#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [5, 6]}}
{"token": ["We", "present", "a", "patient", "with", "C1647218#ent", "<e1>", ",", "in", "whom", "C1279945#ent", "<e2>", "radiologic", "features", "organizing", "pneumonia", "after", "one", "year", "of", "amiodaron", "treatment", "due", "to", "supraventricular", "and", "ventricular", "arrhythmias"], "h": {"id": "C1647218", "name": "C1647218#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1279945", "name": "C1279945#ent", "pos": [10, 11]}}
{"token": ["Their", "interaction", "is", "disrupted", "by", "either", "mutations", "in", "RPGRIP1", ",", "found", "in", "patients", "with", "LCA", ",", "or", "by", "mutations", "in", "C1847013#ent", "<e1>", ",", "found", "in", "patients", "with", "C0687120#ent", "<e2>", "or", "SLSN", "."], "h": {"id": "C1847013", "name": "C1847013#ent", "pos": [20, 21]}, "relation": "has_manifestation", "t": {"id": "C0687120", "name": "C0687120#ent", "pos": [27, 28]}}
{"token": ["To", "evaluate", "whether", "C1705519#ent", "<e1>", "could", "directly", "modulate", "C1538265#ent", "<e2>", "susceptibility", "to", "lysis", ",", "N-RAS/61", "+", "gene", "was", "transfected", "in", "two", "N-RAS", "wild", "type", "N-RAS/61-", ")", "665/2", "melanoma", "clones", "by", "a", "cosmid", "vector"], "h": {"id": "C1705519", "name": "C1705519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1538265", "name": "C1538265#ent", "pos": [8, 9]}}
{"token": ["Primary", "and", "recurrent", "visceral", "forms", "C0033740#ent", "<e1>", "been", "treated", "with", "liposomal", "amphotericin", "B", "while", "C0030864#ent", "<e2>", "successfully", "employed", "as", "treatment", "for", "subsequent", "cutaneous", "relapse", "as", "secondary", "prophylaxis"], "h": {"id": "C0033740", "name": "C0033740#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0030864", "name": "C0030864#ent", "pos": [14, 15]}}
{"token": ["The", "addition", "of", "the", "bone-modulation", "hormones", "to", "the", "culture", "medium", "increased", "C1427121#ent", "<e1>", "activity", "in", "the", "osteoblasts", "derived", "from", "the", "C1539715#ent", "<e2>", "animals", ",", "while", "decreasing", "C1427121#ent", "<e1>", "activity", "in", "the", "CDs", "."], "h": {"id": "C1539715", "name": "C1539715#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1427121", "name": "C1427121#ent", "pos": [11, 12]}}
{"token": ["Visually", "evoked", "responses", "(", "VERs", ")", "were", "recorded", "from", "primary", "visual", "cortex", "unanesthetized", "albino", "rats", "during", "pharmacological", "modulation", "one", "of", "the", "following", "convulsant", "agents", "C0031849#ent", "<e1>", ",", "picrotoxin", ",", "strychnine", "and", "C0947691#ent", "<e2>", "."], "h": {"id": "C0031849", "name": "C0031849#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0947691", "name": "C0947691#ent", "pos": [31, 32]}}
{"token": ["The", "C0398791#ent", "<e1>", "NBS", ")", "is", "caused", "by", "germ", "line", "mutations", "in", "the", "C1705041#ent", "<e2>"], "h": {"id": "C0398791", "name": "C0398791#ent", "pos": [1, 2]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705041", "name": "C1705041#ent", "pos": [13, 14]}}
{"token": ["We", "have", "therefore", "analyzed", "V(D)J", "recombination", "cells", "from", "patients", "with", "C0398791#ent", "<e1>", "carrying", "a", "mutation", "in", "the", "C1705041#ent", "<e2>"], "h": {"id": "C0398791", "name": "C0398791#ent", "pos": [10, 11]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705041", "name": "C1705041#ent", "pos": [17, 18]}}
{"token": ["We", "present", "evidence", "that", "the", "C0812202#ent", "<e1>", "necessary", "and", "sufficient", "for", "resistance", "to", "C1705694#ent", "<e2>", "inhibitors", "."], "h": {"id": "C0812202", "name": "C0812202#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705694", "name": "C1705694#ent", "pos": [13, 14]}}
{"token": ["MS", "treatment", "increased", "C0268731#ent", "<e1>", "both", "mu-OR", "(", "MOR", ")", "C4284124#ent", "<e2>", "and", "delta-OR", "(", "DOR", ")", "KO", "mice", "but", "not", "in", "kappa-OR", "(", "KOR", ")", "KO", "mice"], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [10, 11]}}
{"token": ["Our", "results", "indicate", "that", "LMPTP", ",", "like", "C1706240#ent", "<e1>", ",", "dephosphorylates", "a", "negative", "regulatory", "tyrosine", "site", "in", "a", "C0812288#ent", "<e2>", "thereby", "strengthens", "T", "cell", "receptor", "signaling", "."], "h": {"id": "C1706240", "name": "C1706240#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0812288", "name": "C0812288#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "TTD", "as", "well", "as", "two", "Ca++", "channel", "antagonists", ",", "verapamil", "and", "C0028066#ent", "<e1>", ",", "markedly", "diminished", "C1705725#ent", "<e2>", "and", "PMA-induced", "Ca++", "influx", ",", "Mac-1", "up-regulation", ",", "and", "adhesion", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "anthropometric", "variables", "and", "prevalence", "of", "diabetes", "mellitus", "dyslipidemia", ",", "hypertension", ",", "and", "C0004153#ent", "<e1>", "compared", "among", "17", "postpubertal", "men", "and", "22", "women", "with", "C1720860#ent", "<e2>", "from", "eight", "pedigrees", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [14, 15]}, "relation": "manifestation_of", "t": {"id": "C1720860", "name": "C1720860#ent", "pos": [25, 26]}}
{"token": ["An", "11", "years", "old", "boy", "was", "admitted", "with", "history", "of", "repeated", "C0238990#ent", "<e1>", "constipation", "and", "C0013404#ent", "<e2>", "on", "eating", "solid", "diet", "since", "birth", "."], "h": {"id": "C0238990", "name": "C0238990#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [15, 16]}}
{"token": ["It", "encompasses", "a", "spectrum", "of", "disorders", "including", "multiple", "endocrine", "neoplasia", "types", "1", "MEN1", ")", "and", "2A", ",", "hyperparathyroidism-jaw", "tumour", "syndrome", "HPT-JT", ")", ",", "C4048195#ent", "<e1>", "FHH", ")", ",", "and", "familial", "isolated", "hyperparathyroidism", "C1708291#ent", "<e2>", ")", "."], "h": {"id": "C4048195", "name": "C4048195#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1708291", "name": "C1708291#ent", "pos": [32, 33]}}
{"token": ["In", "contrast", ",", "C1335796#ent", "<e1>", "does", "not", "affect", "transcription", "mediated", "by", "the", "C0812312#ent", "<e2>", "and", "NFAT", "transcription", "factors", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [12, 13]}}
{"token": ["Anopheles", "darlingi", "fed", "on", "eight", "C0024535#ent", "<e1>", "malaria", "patients", "with", "gametocytes", "before", "and", "after", "treatment", "with", "C0034415#ent", "<e2>", "C0034415#ent", "<e2>", "tetracycline", "became", "infected", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0034415", "name": "C0034415#ent", "pos": [16, 17]}}
{"token": ["A", "65-year-old", "man", "developed", "an", "extensive", "C0011603#ent", "<e1>", "with", "pruritus", ",", "urticaria", ",", "and", "C0031256#ent", "<e2>", "1", "week", "after", "receiving", "an", "intramuscular", "injection", "o", "the", "vaccine", "."], "h": {"id": "C0011603", "name": "C0011603#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031256", "name": "C0031256#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "it", "is", "shown", "that", "C1413221#ent", "<e1>", "may", "reduce", "osteoclastogenesis", "and", "increase", "inflammatory", "gene", "induction", "decreasing", "C1333891#ent", "<e2>", "activity", "."], "h": {"id": "C1413221", "name": "C1413221#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [17, 18]}}
{"token": ["Antisense", "oligonucleotides", "AS", ")", "were", "used", "to", "deplete", "neurons", "of", "JNK1", "and", "C1708805#ent", "<e1>", "in", "order", "to", "elucidate", "their", "respective", "roles", "in", "C1705616#ent", "<e2>", "signalling", "."], "h": {"id": "C1708805", "name": "C1708805#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [22, 23]}}
{"token": ["Structurally", "C1334043#ent", "<e1>", "the", "lipocalin", "family", "human", "placental", "protein", "14", "human", "alpha", "1", "microglobulin", "and", "human", "C0243769#ent", "<e2>", "have", "been", "mapped", "to", "this", "region", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0243769", "name": "C0243769#ent", "pos": [16, 17]}}
{"token": ["C1850674#ent", "<e1>", "a", "rare", "congenital", "myopathy", "can", "cause", "progressive", "C0427055#ent", "<e2>", ",", "but", "it", "has", "not", "been", "recognized", "previously", "to", "have", "respiratory", "consequences"], "h": {"id": "C1850674", "name": "C1850674#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [9, 10]}}
{"token": ["Assays", "of", "the", "C0003927#ent", "<e1>", "AHH", ")", "activity", "in", "the", "C4085198#ent", "<e2>", "preparation", "revealed", "decreased", "AHH", "activity", "with", "increase", "in", "Se", "concentration", "."], "h": {"id": "C0003927", "name": "C0003927#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4085198", "name": "C4085198#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "develop", "an", "improved", "test", "to", "detect", "the", "codon", "616", "C0678941#ent", "<e1>", "the", "alpha", "cyclic", "GMP", "phosphodiesterase", "gene", "causes", "progressive", "C0521694#ent", "<e2>", "the", "Cardigan", "Welsh", "Corgi"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0521694", "name": "C0521694#ent", "pos": [26, 27]}}
{"token": ["In", "conclusion", ",", "TA3", "is", "effectively", "C0025517#ent", "<e1>", "in", "rat", "liver", "by", "glucuronidation", "and", "subsequent", "biliary", "excretion", "C1143167#ent", "<e2>", "which", "may", "explain", "its", "rapid", "in", "vivo", "clearance", "relative", "to", "T3", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1143167", "name": "C1143167#ent", "pos": [17, 18]}}
{"token": ["All", "the", "tumors", "were", "stained", "with", "antibodies", "against", "keratin", ",", "vimentin", ",", "S-100", "protein", "Leu-7", ",", "C1880904#ent", "<e1>", "desmin", ",", "muscle-specific", "actin", "myoglobin", ",", "C0949661#ent", "<e2>", "and", "fast", "and", "slow", "myosins", "."], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0949661", "name": "C0949661#ent", "pos": [24, 25]}}
{"token": ["The", "Saccharomyces", "cerevisiae", "gene", "encodes", "a", "RecQ-like", "DNA", "helicase", "human", "homologues", "of", "which", "are", "implicated", "in", "the", "C0019247#ent", "<e1>", "Bloom", "syndrome", "BS", ")", ",", "Rothmund-Thomson", "syndrome", "RTS", ")", ",", "and", "C0043119#ent", "<e2>", "WS", ")", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0043119", "name": "C0043119#ent", "pos": [30, 31]}}
{"token": ["Estrogen", "receptors", "been", "found", "in", "the", "C0700138#ent", "<e1>", "however", ",", "the", "exact", "role", "of", "C2936882#ent", "<e2>", "in", "pancreatic", "enzyme", "synthesis", "and", "secretion", "remains", "to", "be", "elucidated", "."], "h": {"id": "C0700138", "name": "C0700138#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [14, 15]}}
{"token": ["At", "all", "fetal", "ages", ",", "C1442757#ent", "<e1>", "was", "decreased", "in", "the", "C1539862#ent", "<e2>", "group", "compared", "with", "control", "animals"], "h": {"id": "C1442757", "name": "C1442757#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539862", "name": "C1539862#ent", "pos": [11, 12]}}
{"token": ["Two", "antiarrhythmics", "(", "C0059688#ent", "<e1>", "and", "ethmozine", ")", "and", "two", "C0040615#ent", "<e2>", "(", "trifluoperazine", "and", "chlorpromazine", ")", "were", "evaluated", "."], "h": {"id": "C0059688", "name": "C0059688#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [10, 11]}}
{"token": ["The", "patient", "had", "severe", "hydrocephalus", ",", "proximal", "esophageal", "atresia", "distal", "tracheoesophageal", "fistula", "gastric", "outlet", "obstruction", "imperforated", "anus", "C0268875#ent", "<e1>", "patent", "ductus", "arterious", "a", "bifid", "scrotum", "a", "vertebral", "defect", "sacral", "dimple", "C0271801#ent", "<e2>"], "h": {"id": "C0268875", "name": "C0268875#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0271801", "name": "C0271801#ent", "pos": [30, 31]}}
{"token": ["The", "antifungal", "activity", "ZJ-522", ",", "a", "new", "C0003308#ent", "<e1>", "from", "fluconazole", "and", "C0107497#ent", "<e2>", ",", "was", "compared", "to", "that", "of", "fluconazole", "and", "C0107497#ent", "<e2>", "against", "43", "strains", "of", "fungi", "representing", "13", "fungal", "species", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [7, 8]}, "relation": "therapeutic_class_of", "t": {"id": "C0107497", "name": "C0107497#ent", "pos": [12, 13]}}
{"token": ["Treatment", "of", "intact", "human", "neuroblastoma", "CHP100", "cells", "with", "anandamide", "(", "arachidonoylethanolamide", ",", "AEA", ")", "or", "C0299477#ent", "<e1>", "(", "2-AG", ")", "inhibits", "intracellular", "C0531004#ent", "<e2>", "FAAH", ")", "."], "h": {"id": "C0299477", "name": "C0299477#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0531004", "name": "C0531004#ent", "pos": [22, 23]}}
{"token": ["Clinical", "features", "are", "similar", "to", "those", "of", "C0014118#ent", "<e1>", "due", "to", "nonanaerobic", "organisms", ",", "but", "underlying", "C0018799#ent", "<e2>", "less", "common", "and", "the", "rate", "of", "thromboembolic", "complications", "is", "high", "."], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [16, 17]}}
{"token": ["C0600438#ent", "<e1>", ",", "which", "are", "inhibitors", "of", "C1421249#ent", "<e2>", "abolished", "the", "anti-phosphotyrosine", "staining", "inhibited", "the", "kinase", "activity", "slowed", "tip", "growth", "affected", "the", "organisation", "of", "the", "actin", "cytoskeleton", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0600438", "name": "C0600438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [7, 8]}}
{"token": ["Disseminated", "disease", "constitutional", "signs", "symptoms", ",", "intermittent", "oligoarticular", "arthritis", ",", "C0025297#ent", "<e1>", ",", "cranial", "neuritis", "radiculoneuropathy", ",", "encephalopathy", ",", "C0004245#ent", "<e2>", "and", "myopericarditis", "."], "h": {"id": "C0025297", "name": "C0025297#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004245", "name": "C0004245#ent", "pos": [19, 20]}}
{"token": ["The", "Ki", "values", "of", "C0910065#ent", "<e1>", "for", "inhibition", "of", "C0960371#ent", "<e2>", "human", "plasmin", "are", "in", "the", "nanomolar", "range", ";", "no", "inhibition", "was", "detected", "for", "factor", "Xa", "thrombin", ",", "tissue", "kallikrein", "plasma", "kallikrein", "chymotrypsin", "."], "h": {"id": "C0910065", "name": "C0910065#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0960371", "name": "C0960371#ent", "pos": [9, 10]}}
{"token": ["The", "effect", "of", "C0286651#ent", "<e1>", "on", "warfarin-induced", "aortic", "medial", "calcification", "and", "systolic", "blood", "pressure", "C1705296#ent", "<e2>", ")", "of", "rats", "induced", "by", "warfarin", "was", "studied", "."], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705296", "name": "C1705296#ent", "pos": [14, 15]}}
{"token": ["Recent", "case", "reports", "C0036474#ent", "<e1>", "indicate", "that", "C0036474#ent", "<e1>", "be", "more", "prevalent", "that", "generally", "assumed", "."], "h": {"id": "C0036474", "name": "C0036474#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0036474", "name": "C0036474#ent", "pos": [3, 4]}}
{"token": ["According", "to", "this", "latest", "publication", "major", "manifestations", "are", "C0869523#ent", "<e1>", ",", "polyarthritis", ",", "chorea", ",", "C0041834#ent", "<e2>", "subcutaneous", "nodules"], "h": {"id": "C0869523", "name": "C0869523#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [15, 16]}}
{"token": ["Of", "these", "20", "patients", ",", "17", "had", "neuroborreliosis", ",", "one", "had", "arthritis", "and", "C0869523#ent", "<e1>", ",", "one", "had", "myalgia", ",", "and", "one", "had", "C0041834#ent", "<e2>", "and", "arthralgia", "."], "h": {"id": "C0869523", "name": "C0869523#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [23, 24]}}
{"token": ["Two-", "to", "three-fold", "increases", "in", "both", "the", "sensitivity", "and", "maximum", "responsiveness", "of", "AC", "to", "the", "C0001644#ent", "<e1>", "isoproterenol", "were", "consistently", "observed", "in", "fractions", "prepared", "from", "the", "C1307053#ent", "<e2>", "overexpressing", "cells"], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1307053", "name": "C1307053#ent", "pos": [26, 27]}}
{"token": ["Inhibitors", "of", "corticosteroid", "production", "(", "e.g.", "C0022625#ent", "<e1>", ",", "metyrapone", ",", "aminoglutethimide", ")", ",", "rather", "than", "C0003290#ent", "<e2>", "are", "generally", "successful", "in", "relieving", "depressive", "symptoms", "as", "well", "as", "other", "disabling", "symptoms", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003290", "name": "C0003290#ent", "pos": [16, 17]}}
{"token": ["Some", "bipolar", "cells", "positively", "to", "C1880904#ent", "<e1>", "were", "immunonegative", "for", "C0010803#ent", "<e2>", "and", "glia-specific", "proteins", ",", "suggesting", "that", "they", "were", "ORNs", "."], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [10, 11]}}
{"token": ["They", "also", "showed", "focally", "positive", "staining", "with", "a", "C1880904#ent", "<e1>", "while", "they", "showed", "no", "immunoreactivity", "to", "C0010803#ent", "<e2>", "or", "epithelial", "membrane", "antigen"], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010803", "name": "C0010803#ent", "pos": [16, 17]}}
{"token": ["Therefore", ",", "the", "cAMP", "responsiveness", "of", "the", "tyrosinase", "promoter", "probably", "is", "mediated", "by", "C0206138#ent", "<e1>", "and", "not", "C1415350#ent", "<e2>", "sites", ",", "since", "the", "truncated", "promoter", "the", "former", "but", "not", "the", "latter", "regions", "."], "h": {"id": "C0206138", "name": "C0206138#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415350", "name": "C1415350#ent", "pos": [17, 18]}}
{"token": ["A", "Caenorhabditis", "elegans", "gene", "was", "cloned", "encoding", "a", "HECT", "domain", "protein", "C1538115#ent", "<e1>", ")", ",", "which", "was", "highly", "C1334043#ent", "<e2>", "to", "murine", "and", "human", "WWP1", "."], "h": {"id": "C1538115", "name": "C1538115#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [18, 19]}}
{"token": ["We", "have", "identified", "two", "highly", "conserved", "RING", "finger", "proteins", "ROC1", "and", "C1419428#ent", "<e1>", ",", "that", "are", "C1334043#ent", "<e2>", "to", "APC11", ",", "a", "subunit", "of", "the", "anaphase-promoting", "complex"], "h": {"id": "C1419428", "name": "C1419428#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}}
{"token": ["Potent", "and", "selective", "receptor", "antagonists", "been", "developed", "and", "have", "shown", "promising", "results", "in", "the", "treatment", "of", "cardiovascular", "diseases", "as", "C2973725#ent", "<e1>", "acute", "and", "chronic", "heart", "failure", "hypertension", ",", "renal", "failure", "and", "C0004153#ent", "<e2>", "."], "h": {"id": "C2973725", "name": "C2973725#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [31, 32]}}
{"token": ["This", "monoclonal", "antibody", "with", "PG1", "and", "C1414069#ent", "<e1>", "from", "shark", "cartilage", "also", "with", "C1412277#ent", "<e2>", "from", "bovine", "trachea", "cartilage", "."], "h": {"id": "C1414069", "name": "C1414069#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412277", "name": "C1412277#ent", "pos": [13, 14]}}
{"token": ["In", "DRN", ",", "the", "effect", "of", "C0075632#ent", "<e1>", "was", "blocked", "by", "C1412820#ent", "<e2>", "15572", "but", "not", "by", "WAY", "100635", "SB", "216641", "."], "h": {"id": "C0075632", "name": "C0075632#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412820", "name": "C1412820#ent", "pos": [11, 12]}}
{"token": ["We", "hypothesized", "that", "this", "C1419024#ent", "<e1>", "hyperphosphorylation", "could", "reflect", "mutational", "activation", "C1419384#ent", "<e2>", "or", "Rheb-like", "protein", "(", "RhebL1", ")", ",", "Ras", "family", "members", "directly", "activate", "mTOR", "."], "h": {"id": "C1419024", "name": "C1419024#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419384", "name": "C1419384#ent", "pos": [11, 12]}}
{"token": ["Exploitation", "of", "the", "three", "sites", "of", "diversity", "present", "in", "the", "cyclosulfamide", "scaffold", "yielded", "compounds", "which", "inhibited", "C1414369#ent", "<e1>", "but", "not", "proteinase", "3", "PR", "3", ")", "or", "C0041236#ent", "<e2>"], "h": {"id": "C1414369", "name": "C1414369#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [26, 27]}}
{"token": ["A", "strong", "in", "vitro", "inhibiting", "activity", "toward", "chymotrypsin", "and", ",", "to", "a", "lesser", "extent", ",", "toward", "human", "C1414369#ent", "<e1>", "present", ",", "while", "C0041236#ent", "<e2>", ",", "Carlsberg", "subtilisin", "human", "thrombin", "and", "pancreatic", "elastase", "to", "react", "."], "h": {"id": "C1414369", "name": "C1414369#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [22, 23]}}
{"token": ["CYFRA", "21", "-", "1", "serum", "levels", "were", "elevated", "in", "benign", "conditions", "such", "as", "C0023890#ent", "<e1>", "but", "not", "in", "endometriosis", "and", "C1290884#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [20, 21]}}
{"token": ["Chlamydia", "trachomatis", "a", "common", "cause", "of", "genital", "infection", "can", "give", "rise", "to", "urethritis", "and", "C0014534#ent", "<e1>", "in", "men", "and", "C0007860#ent", "<e2>", "and", "pelvic", "inflammatory", "disease", "women", "."], "h": {"id": "C0014534", "name": "C0014534#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0007860", "name": "C0007860#ent", "pos": [19, 20]}}
{"token": ["The", "expression", "of", "C1417679#ent", "<e1>", "involved", "in", "primary", "nitrogen", "assimilation", "such", "as", "C3890009#ent", "<e2>", "(", "chloroplastic", "glutamine", "synthetase", "and", "Nia", "(nitrate", "reductase", "EC", "1.6.1.1", ")", "was", "also", "analysed", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3890009", "name": "C3890009#ent", "pos": [12, 13]}}
{"token": ["In", "a", "genetically", "unique", "colony", "of", "C0039663#ent", "<e1>", "susceptible", "(", "THC-SS", ")", "rabbits", ",", "C0159020#ent", "<e2>", "elicited", "by", "delta", "9THC", ",", "the", "major", "psychoactive", "ingredient", "of", "marijuana", "."], "h": {"id": "C0039663", "name": "C0039663#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0159020", "name": "C0159020#ent", "pos": [14, 15]}}
{"token": ["An", "analogous", "expression", "pattern", "of", "the", "C0001473#ent", "<e1>", "found", "in", "C1412726#ent", "<e2>", "of", "adult", "rat", "and", "hamster", "."], "h": {"id": "C0001473", "name": "C0001473#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [10, 11]}}
{"token": ["The", "calculated", "activities", "of", "the", "ATP-activated", "cytosolic", "and", "lysosomal", "C3540017#ent", "<e1>", "and", "of", "the", "ATP-inhibited", "C1425101#ent", "<e2>", "not", "explain", "the", "observed", "release", "of", "purines", "under", "the", "conditions", "examined", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1425101", "name": "C1425101#ent", "pos": [15, 16]}}
{"token": ["The", "global", "dissemination", "drug-resistant", "Plasmodium", "falciparum", "spurring", "intense", "efforts", "to", "implement", "artemisinin", "(ART)-based", "combination", "therapies", "C0024530#ent", "<e1>", ",", "including", "mefloquine", "(MFQ)-artesunate", "and", "C0531104#ent", "<e2>", "(LUM)-artemether", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0531104", "name": "C0531104#ent", "pos": [22, 23]}}
{"token": ["Deletion", "of", "repetitive", "extragenic", "palindromic", "elements", "between", "aceA", "and", "C0919509#ent", "<e1>", "had", "little", "effect", "on", "the", "relative", "expression", "of", "these", "C1417679#ent", "<e2>", "."], "h": {"id": "C0919509", "name": "C0919509#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}}
{"token": ["The", "LTK", "binding", "site", "C1705297#ent", "<e1>", "was", "tyrosine", "862", "at", "the", "C1416809#ent", "<e2>", "to", "a", "lesser", "extent", "tyrosine", "485", "at", "the", "juxtamembrane", "domain", "."], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416809", "name": "C1416809#ent", "pos": [11, 12]}}
{"token": ["C0024027#ent", "<e1>", "increases", "mRNA", "levels", "for", "C0243650#ent", "<e2>", "while", "mevalonic", "acid", "low-density", "lipoprotein", "and", "25-hydroxycholesterol", "decrease", "mRNA", "levels", "to", "40", "-", "50", "%", "of", "control", "values", "."], "h": {"id": "C0024027", "name": "C0024027#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243650", "name": "C0243650#ent", "pos": [6, 7]}}
{"token": ["Infantile", "Refsum's", "disease", "IRD", ")", "is", "a", "peroxisomal", "deficiency", "disease", "is", "closely", "related", "to", "C0282525#ent", "<e1>", "NALD", ")", "and", "the", "Zellweger", "syndrome", "C0043459#ent", "<e2>", ")", "."], "h": {"id": "C0282525", "name": "C0282525#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "show", "that", "flight", "metabolic", "rate", "and", "the", "frequency", "of", "a", "specific", "C1706112#ent", "<e1>", "of", "the", "C1333690#ent", "<e2>", "pgi", ")", "were", "both", "highest", "in", "newly", "established", ",", "isolated", "populations", "."], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333690", "name": "C1333690#ent", "pos": [17, 18]}}
{"token": ["This", "study", "suggests", "that", "C1413752#ent", "<e1>", "acts", "by", "inhibiting", "IL-2", "production", "(", "via", "blockade", "of", "C1705753#ent", "<e2>", "expression", ")", "rather", "than", "by", "preventing", "the", "expression", "of", "the", "IL-2", "receptor"], "h": {"id": "C1413752", "name": "C1413752#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705753", "name": "C1705753#ent", "pos": [15, 16]}}
{"token": ["These", "results", "reveal", "a", "novel", "BCR", "signaling", "pathway", "to", "the", "activation", "of", "C1417018#ent", "<e1>", "and", "subsequently", "C3272750#ent", "<e2>", ",", "in", "which", "BASH", "recruits", "tyrosine-phosphorylated", "C1417018#ent", "<e1>", "into", "the", "BCR", "signaling", "complex"], "h": {"id": "C3272750", "name": "C3272750#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417018", "name": "C1417018#ent", "pos": [12, 13]}}
{"token": ["Then", ",", "the", "mRNA", "level", "of", "cytosolic", "phospholipase", "A2", "C1333931#ent", "<e1>", ")", ",", "cyclooxygenases", "(COX)-1", "and", "-2", ",", "C0243769#ent", "<e2>", "and", "-2", "was", "detected", "using", "reverse", "transcription", "polymerase", "chain", "reaction", "RT-PCR", ")", "."], "h": {"id": "C1333931", "name": "C1333931#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243769", "name": "C0243769#ent", "pos": [18, 19]}}
{"token": ["The", "therapy", "had", "a", "significant", "effect", "on", "symptoms", "(", "vaginal", "dryness", "C0033778#ent", "<e1>", "dyspareunia", ",", "urinary", "urgency", "and", "on", "signs", "of", "C0156409#ent", "<e2>", "with", "cure/improvement", "registered", "in", ">", "or", "=", "90", "%", "."], "h": {"id": "C0033778", "name": "C0033778#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0156409", "name": "C0156409#ent", "pos": [21, 22]}}
{"token": ["Hyrec", "plants", "were", "found", "to", "perform", "C1826402#ent", "<e1>", "efficiently", "as", "the", "C1883559#ent", "<e2>", "ruling", "out", "the", "possibility", "that", "the", "increase", "in", "homologous", "recombination", "due", "to", "a", "defect", "in", "end", "joining", "."], "h": {"id": "C1826402", "name": "C1826402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "show", "that", "C1314754#ent", "<e1>", "and", "its", "homologs", "APOBEC3C", "and", "C1424930#ent", "<e2>", "potent", "DNA", "mutator", "activity", "in", "an", "E.", "coli", "assay"], "h": {"id": "C1314754", "name": "C1314754#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424930", "name": "C1424930#ent", "pos": [12, 13]}}
{"token": ["Oral", "treatment", "C0022625#ent", "<e1>", "prevented", "and", "cured", "artificial", "crop", "candidosis", "of", "the", "turkey", ",", "C0700345#ent", "<e2>", "the", "rat", "and", "skin", "candidosis", "the", "guinea-pig", "."], "h": {"id": "C0022625", "name": "C0022625#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0700345", "name": "C0700345#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "the", "Rad", "family", "C0752092#ent", "<e1>", "unique", "characteristics", "of", "binding", "CaM", "C0248868#ent", "<e2>", "suggesting", "a", "role", "for", "Rad-like", "GTPases", "in", "calcium", "activation", "serine/threonine", "kinase", "cascades"], "h": {"id": "C0752092", "name": "C0752092#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0248868", "name": "C0248868#ent", "pos": [12, 13]}}
{"token": ["Oral", "long-acting", "C0012373#ent", "<e1>", "was", "77", "%", "effective", "in", "controlling", "ventricular", "response", "48", "hours", "in", "patients", "with", "C0004238#ent", "<e2>", "or", "AFl", "in", "whom", "ventricular", "response", "initially", "controlled", "with", "intravenous", "C0012373#ent", "<e1>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0012373", "name": "C0012373#ent", "pos": [2, 3]}}
{"token": ["In", "this", "work", ",", "CE", "separation", "with", "end-column", "Ru(bpy)3(2", "+", ")", "C1705075#ent", "<e1>", "detection", "for", "the", "quantitative", "determination", "of", "C0054668#ent", "<e2>", "was", "firstly", "performed", "."], "h": {"id": "C1705075", "name": "C1705075#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0054668", "name": "C0054668#ent", "pos": [19, 20]}}
{"token": ["The", "mRNA", "expression", "levels", "of", "C1413893#ent", "<e1>", "and", "several", "nuclear", "receptors", "to", "regulate", "the", "C2976704#ent", "<e2>", "assayed", "in", "human", "primary", "hepatocytes", "by", "quantitative", "real-time", "PCR", "Q-PCR", ")", "."], "h": {"id": "C1413893", "name": "C1413893#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2976704", "name": "C2976704#ent", "pos": [14, 15]}}
{"token": ["The", "C0006938#ent", "<e1>", "C1YVV", "isolates", "of", "strain", "1", "including", "the", "Australian", "C1875400#ent", "<e2>", "C1YVV-B", ",", "had", "93", "to", "98", "%", "nucleotide", "identities", "97", "to", "99.6", "%", "amino", "acid", "identities", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [11, 12]}}
{"token": ["Endothelial", "cells", "biopsied", "blood", "vessels", "C1336938#ent", "<e1>", "Doberman", "pinscher", "dogs", "contain", "immunologically", "detectable", "C1336938#ent", "<e1>", "."], "h": {"id": "C1336938", "name": "C1336938#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [5, 6]}}
{"token": ["This", "observation", "is", "consistent", "with", "previous", "findings", "that", "both", "the", "ability", "of", "endothelial", "cells", "proliferate", "in", "response", "to", "C1367482#ent", "<e1>", "and", "the", "expression", "of", "an", "C0051844#ent", "<e2>", "the", "cell", "surface", "on", "cell", "density"], "h": {"id": "C1367482", "name": "C1367482#ent", "pos": [18, 19]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [25, 26]}}
{"token": ["These", "properties", ",", "the", "amino", "acid", "composition", ",", "insensitivity", "to", "C0013618#ent", "<e1>", ",", "and", "inhibition", "patterns", "show", "general", "similarities", "to", "other", "C0054318#ent", "<e2>"], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0054318", "name": "C0054318#ent", "pos": [21, 22]}}
{"token": ["However", ",", "MMP", "species", "are", "not", "uniformly", "increased", "in", "patients", "with", "end-stage", "C0019099#ent", "<e1>", ",", "suggesting", "that", "a", "specific", "portfolio", "of", "C0623362#ent", "<e2>", "are", "expressed", "in", "the", "failing", "myocardium", "."], "h": {"id": "C0019099", "name": "C0019099#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [21, 22]}}
{"token": ["For", "yeast", "cells", "in", "media", "with", "different", "C0524928#ent", "<e1>", "sources", ",", "no", "correlation", "was", "found", "between", "repression", "of", "C0016755#ent", "<e2>", "and", "intracellular", "levels", "of", "glucose", "6-phosphate", "fructose", "1,6-bisphosphate"], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0016755", "name": "C0016755#ent", "pos": [18, 19]}}
{"token": ["Information", "on", "several", "new", "and", "specific", "C0040085#ent", "<e1>", "including", "ICI-D1694", ",", "1843U89", ",", "AG-331", ",", "and", "C0281733#ent", "<e2>", ",", "is", "presented", "."], "h": {"id": "C0040085", "name": "C0040085#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0281733", "name": "C0281733#ent", "pos": [16, 17]}}
{"token": ["C0028096#ent", "<e1>", "was", "administered", "on", "C1414052#ent", "<e2>", "and", "D3", "at", "the", "dosage", "of", "1", "mg/kg", "body", "weight"], "h": {"id": "C0028096", "name": "C0028096#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [5, 6]}}
{"token": ["Irrespective", "of", "the", "type", "of", "leprosy", "the", "sex", "of", "leprosy", "patient", ",", "mortalities", "were", "increased", "from", "tuberculosis", ",", "C1535939#ent", "<e1>", "and", "bronchitis", ",", "C0031065#ent", "<e2>", "and", "nephrosis", ",", "and", "from", "total", "causes", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0031065", "name": "C0031065#ent", "pos": [23, 24]}}
{"token": ["We", "report", "a", "case", "of", "C0002726#ent", "<e1>", "in", "association", "with", "hyperimmunoglobulinemia", "D", "syndrome", "C0342731#ent", "<e2>", ")", "."], "h": {"id": "C0002726", "name": "C0002726#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0342731", "name": "C0342731#ent", "pos": [13, 14]}}
{"token": ["Combination", "therapy", "a", "significant", "advance", "in", "the", "treatment", "of", "C0019196#ent", "<e1>", "patients", "with", "C0019247#ent", "<e2>"], "h": {"id": "C0019196", "name": "C0019196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [13, 14]}}
{"token": ["Our", "main", "C1413231#ent", "<e1>", "consists", "of", "investigating", "the", "clinical", "usefulness", "gelatinases", "and", "their", "C0003015#ent", "<e2>", "non-small", "cell", "lung", "cancer", "NSCLC", ")", "."], "h": {"id": "C1413231", "name": "C1413231#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003015", "name": "C0003015#ent", "pos": [13, 14]}}
{"token": ["C0086376#ent", "<e1>", "coded", "by", "C1709313#ent", "<e2>", "are", "responsible", "for", "immortalization", "and", "initiation", "of", "transformation", ",", "those", "coded", "by", "E1b", "--", "for", "complete", "transformation", "and", "tumourigenicity", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [4, 5]}}
{"token": ["This", "suggests", "that", "the", "inability", "of", "the", "C0031727#ent", "<e1>", "confer", "resistance", "to", "C0596823#ent", "<e2>", "tomato", "is", "not", "caused", "by", "altered", "recognition", "specificity", "Pti1", "phosphorylation", "sites", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0596823", "name": "C0596823#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "stimulated", "C1860224#ent", "<e1>", "from", "AIDS", "patients", "who", "receive", "CCs", "for", "treatment", "of", "C0031381#ent", "<e2>", "release", "significantly", "less", "IL1", "beta", "TNF", "alpha", "AM", "from", "patients", "not", "receiving", "CCs", "."], "h": {"id": "C1860224", "name": "C1860224#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [14, 15]}}
{"token": ["The", "C1416661#ent", "<e1>", "Klfs", ")", "family", "of", "C0017362#ent", "<e2>", "transcription", "factors", "in", "many", "biological", "processes", "including", "proliferation", ",", "apoptosis", ",", "differentiation", "and", "development", "."], "h": {"id": "C1416661", "name": "C1416661#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017362", "name": "C0017362#ent", "pos": [7, 8]}}
{"token": ["A", "great", "number", "of", "azole", "derivatives", ",", "such", "as", "oxiconazole", ",", "isoconazole", ",", "C0144004#ent", "<e1>", ",", "and", "terconazole", ",", "are", "used", "as", "C0003308#ent", "<e2>"], "h": {"id": "C0144004", "name": "C0144004#ent", "pos": [13, 14]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [22, 23]}}
{"token": ["In", "liver", "cell", "nuclei", "male", "rats", "but", "not", "female", "rats", ",", "constitutive", "androstane", "receptor", "CAR", ")", "and", "proliferator-activated", "receptor", "alpha", "C2984537#ent", "<e1>", ")", "protein", "levels", "significantly", "enhanced", "by", "intake", "of", "the", "C1538440#ent", "<e2>"], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [31, 32]}}
{"token": ["This", "was", "not", "the", "case", "for", "the", "SH2", "domain", "C0812317#ent", "<e1>", ",", "however", ",", "as", "binding", "of", "the", "C0084219#ent", "<e2>", "Cbl", "appeared", "to", "require", "multiple", "domains"], "h": {"id": "C0812317", "name": "C0812317#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0084219", "name": "C0084219#ent", "pos": [18, 19]}}
{"token": ["C0426576#ent", "<e1>", "commonly", "reported", "as", "side-effects", "of", "C0020615#ent", "<e2>"], "h": {"id": "C0426576", "name": "C0426576#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [7, 8]}}
{"token": ["The", "epidermis", "represented", "the", "major", "transport", "barrier", "in", "vitro", "C0066412#ent", "<e1>", "nicotinic", "acid", "not", "for", "C0062684#ent", "<e2>"], "h": {"id": "C0066412", "name": "C0066412#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0062684", "name": "C0062684#ent", "pos": [15, 16]}}
{"token": ["C0033321#ent", "<e1>", "has", "been", "reported", "to", "antagonize", "C0039659#ent", "<e2>", "CCK-8", ")", "in", "peripheral", "tissue", "in", "neurophysiological", "single", "unit", "preparations", "."], "h": {"id": "C0033321", "name": "C0033321#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039659", "name": "C0039659#ent", "pos": [7, 8]}}
{"token": ["The", "ATP", "phosphohydrolase", "activity", "of", "the", "C0300252#ent", "<e1>", "not", "activated", "by", "trypsin", "treatment", "and", "the", "C0001473#ent", "<e2>", "(", "BF0F1", ")", "contained", "no", "trypsin-sensitive", "inhibitor", "protein", "subunit", "."], "h": {"id": "C0300252", "name": "C0300252#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [15, 16]}}
{"token": ["S100A4", "had", "a", "greater", "affinity", "for", "wild-type", "or", "mutant", "arg-175-his", "C1705526#ent", "<e1>", "than", "for", "C0949646#ent", "<e2>"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0949646", "name": "C0949646#ent", "pos": [14, 15]}}
{"token": ["Experimentally", ",", "halothane", "and", "enflurane", "have", "direct", "cardiac", "inhibitory", "similar", "to", "C0042523#ent", "<e1>", "and", "diltiazem", ",", "whereas", "C0022180#ent", "<e2>", "properties", "seem", "closer", "to", "the", "dihydropyridines", "(", "nifedipine", "and", "nicardipine", ")", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [17, 18]}}
{"token": ["To", "compare", "the", "effects", "between", "isoprenoids", "and", "C1419277#ent", "<e1>", "on", "the", "GTP-hydrolysis", "of", "C0525678#ent", "<e2>", ",", "we", "applied", "the", "GTP-locked", "shrimp", "mutant", "S-Ras(Q(61)K", ")", "and", "GTP-locked", "rat", "mutant", "K(B)-ras(Q(61)K", ")", "."], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [13, 14]}}
{"token": ["The", "anti-inflammatory", "drug", "celecoxib", "potentiates", "the", "efficacy", "of", "several", "C0010858#ent", "<e1>", "and", "neurotropic", "drugs", "are", "known", "C1422070#ent", "<e2>", "substrates", "."], "h": {"id": "C0010858", "name": "C0010858#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422070", "name": "C1422070#ent", "pos": [16, 17]}}
{"token": ["L-Leucine", ",", "but", "not", "D-leucine", ",", "was", "converted", "to", "C0001002#ent", "<e1>", "with", "a", "stoichiometry", "of", "approximately", "0.61", "mol", "of", "C0001002#ent", "<e1>", "per", "mol", "of", "C0281255#ent", "<e1>", "."], "h": {"id": "C0001002", "name": "C0001002#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0281255", "name": "C0281255#ent", "pos": [24, 25]}}
{"token": ["Pre-treatment", "with", "C0025853#ent", "<e1>", "appeared", "to", "reduce", "both", "of", "these", "effects", "of", "C1413167#ent", "<e2>", ",", "but", "only", "the", "decrease", "in", "cortisol", "was", "statistically", "significant"], "h": {"id": "C0025853", "name": "C0025853#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413167", "name": "C1413167#ent", "pos": [12, 13]}}
{"token": ["The", "slow", "C1425078#ent", "<e1>", "depends", "on", "both", "substance", "P", "C0017789#ent", "<e2>", "NMDA-receptor-mediated", "neurotransmission", ";", "isoflurance", "and", "dexmedetomidine", "depressed", "responses", "both", "substance", "P", "NMDA", "."], "h": {"id": "C1425078", "name": "C1425078#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [9, 10]}}
{"token": ["Our", "data", "indicate", "resemblance", "of", "the", "clinical", "manifestations", "RE", "with", "C0270853#ent", "<e1>", "and", "other", "cognitive", "function-related", "C0751495#ent", "<e2>", "and", "point", "toward", "an", "overlap", "with", "them", "."], "h": {"id": "C0270853", "name": "C0270853#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [16, 17]}}
{"token": ["He", "was", "found", "to", "have", "C1855119#ent", "<e1>", "79", "mumol", "per", "milligram", "of", "creatinine", ")", "and", "C0019880#ent", "<e2>", "(", "0.85", "mumol", "per", "milligram", "of", "creatinine", ")", "."], "h": {"id": "C1855119", "name": "C1855119#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0019880", "name": "C0019880#ent", "pos": [15, 16]}}
{"token": ["To", "study", "this", "phenomenon", "in", "vitro", "rat", "C0699919#ent", "<e1>", "EC", "3.4.22.1", ")", ",", "a", "lysosomal", "proteinase", "and", "a", "typical", "C2987171#ent", "<e2>", ",", "rat", "serum", "haptoglobin", "were", "purified", "."], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987171", "name": "C2987171#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "we", "show", "that", "the", "EGFR", "associates", "with", "NF-kappaB-inducing", "kinase", "NIK", ")", "and", "provide", "evidence", "suggesting", "C0751283#ent", "<e1>", "formation", "between", "the", "EGFR", ",", "C1826849#ent", "<e2>", ",", "and", "NIK", "."], "h": {"id": "C0751283", "name": "C0751283#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1826849", "name": "C1826849#ent", "pos": [24, 25]}}
{"token": ["End-tidal", "C1537986#ent", "<e1>", "tensions", "rose", "during", "sleep", "stages", "I", "C3273406#ent", "<e2>", "and", "V", "(", "REM", ")", "in", "association", "with", "reduced", "chest", "wall", "excursion", ",", "suggesting", "transient", "episodes", "of", "mild", "hypoventilation", "were", "not", "associated", "with", "arousals", "."], "h": {"id": "C1537986", "name": "C1537986#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [9, 10]}}
{"token": ["C0017082#ent", "<e1>", "absent", "in", "C1512488#ent", "<e2>", "normal", "tissues", "have", "been", "found", "in", "minute", "amounts", "human", "gastric", "and", "mammary", "tumours"], "h": {"id": "C0017082", "name": "C0017082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [4, 5]}}
{"token": ["The", "C0105421#ent", "<e1>", "associates", "with", "two", "classes", "of", "tyrosine", "kinase", "Src-family", "kinase", "Lyn", ",", "C1442788#ent", "<e2>", ",", "Blk", "or", "Lck", ")", "and", "Syk", "kinase"], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [14, 15]}}
{"token": ["Besides", "beta-blockers", "and", "antidepressants", ",", "several", "drugs", "used", "in", "cancer", "therapy", "as", "well", "as", "PPIs", ",", "C0003211#ent", "<e1>", ",", "vitamin", "K-antagonists", "and", "C0362046#ent", "<e2>", "metabolized", "via", "these", "enzymes", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [22, 23]}}
{"token": ["In", "the", "Western", "blot", "analysis", "C0633225#ent", "<e1>", "the", "antiapoptotic", "Bcl-2", "protein", "down-regulated", ",", "and", "C0010656#ent", "<e2>", "were", "up-regulated", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [14, 15]}}
{"token": ["Five", "patients", "had", "C0339573#ent", "<e1>", "three", "and", "pigmentary", "glaucoma", "one", "and", "juvenile", "glaucoma", "and", "one", "had", "C1280768#ent", "<e2>"], "h": {"id": "C0339573", "name": "C0339573#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1280768", "name": "C1280768#ent", "pos": [16, 17]}}
{"token": ["We", "now", "report", "the", "sequence", "of", "the", "cloned", "2", "129-base", "C1333237#ent", "<e1>", "the", "location", "of", "the", "C1413284#ent", "<e2>", "coding", "region", "the", "sequence", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413284", "name": "C1413284#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "the", "brain", "IGF-I", "receptor", "not", "cleaved", "by", "neuraminidase", ",", "whereas", ",", "the", "placental", "IGF-I", "receptor", "increased", "mobility", "on", "C0272170#ent", "<e1>", "gels", "following", "C0027803#ent", "<e2>"], "h": {"id": "C0272170", "name": "C0272170#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0027803", "name": "C0027803#ent", "pos": [24, 25]}}
{"token": ["The", "C0042397#ent", "<e1>", "vasodilator", "capacity", "was", "tested", "in", "the", "acute", "phase", "C0002575#ent", "<e2>", "and", "acetazolamide", ",", "respectively", "."], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [11, 12]}}
{"token": ["C0393992#ent", "<e1>", "in", "approximately", "20", "%", "of", "C1332416#ent", "<e2>", "cotwins", "after", "second-", "and", "third-trimester", "intrauterine", "fetal", "death", "one", "twin", "in", "monochorionic", "pregnancies"], "h": {"id": "C0393992", "name": "C0393992#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [7, 8]}}
{"token": ["In", "our", "institution", ",", "0.05", "%", "C0357797#ent", "<e1>", "is", "the", "preferred", "C0042397#ent", "<e2>", "for", "FESS", "in", "children", "."], "h": {"id": "C0357797", "name": "C0357797#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [11, 12]}}
{"token": ["Four", "principal", "components", "their", "C0003864#ent", "<e1>", "emerged", ",", "namely", ":", "spondylitis", ",", "sacroiliitis", ",", "C0162323#ent", "<e2>", "oligoarthritis", "(", "involvement", "of", "one", "or", "two", "large", "joints", ")", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0162323", "name": "C0162323#ent", "pos": [14, 15]}}
{"token": ["However", ",", "more", "C0234376#ent", "<e1>", "were", "associated", "with", "zuclopenthixol", "as", "was", "a", "tendency", "for", "C3714760#ent", "<e2>", "be", "unmasked", "at", "the", "end", "of", "the", "injection", "interval"], "h": {"id": "C0234376", "name": "C0234376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714760", "name": "C3714760#ent", "pos": [14, 15]}}
{"token": ["In", "order", "to", "investigate", "the", "dietary", "effect", "C2936886#ent", "<e1>", "on", "aluminum-induced", "hypophosphatemia", ",", "five", "types", "of", "diet", ",", "C1161331#ent", "<e2>", ",", "lactose", ",", "milk", ",", "casein", "and", "soy", "protein", "were", "prepared", "."], "h": {"id": "C2936886", "name": "C2936886#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [18, 19]}}
{"token": ["Enzyme", "activity", "inhibited", "by", "C0012695#ent", "<e1>", "and", "2,3-bisphosphoglycerate", ",", "both", "inhibitors", "of", "native", "C1416444#ent", "<e2>", "but", "not", "by", "EGTA", "and", "LiCl", ",", "as", "previously", "shown", "for", "the", "bovine", "brain", "enzyme"], "h": {"id": "C0012695", "name": "C0012695#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416444", "name": "C1416444#ent", "pos": [13, 14]}}
{"token": ["The", "key", "question", "may", "be", "of", "whether", "this", "disorder", "involves", "virus", "specific", "immune", "attacks", "the", "C0036091#ent", "<e1>", "a", "site", "for", "C0149678#ent", "<e2>", "latency", "."], "h": {"id": "C0036091", "name": "C0036091#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0149678", "name": "C0149678#ent", "pos": [20, 21]}}
{"token": ["Pharmacokinetic", "and", "pharmacodynamic", "gender", "in", "C0017302#ent", "<e1>", "especially", "significant", "for", "propofol", "and", "C0010464#ent", "<e2>"], "h": {"id": "C0017302", "name": "C0017302#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010464", "name": "C0010464#ent", "pos": [12, 13]}}
{"token": ["The", "present", "findings", "suggest", "that", "bradykinin", "and", "C3850105#ent", "<e1>", "converted", "by", "C0007075#ent", "<e2>", "into", "biologically", "active", "receptor", "agonist", "or", "antagonists", "."], "h": {"id": "C3850105", "name": "C3850105#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007075", "name": "C0007075#ent", "pos": [11, 12]}}
{"token": ["The", "C1416920#ent", "<e1>", "and", "Spo0E", "families", "of", "C0031686#ent", "<e2>", "dephosphorylate", "the", "sporulation", "response", "regulators", "Spo0F", "and", "Spo0A", ",", "respectively", "."], "h": {"id": "C1416920", "name": "C1416920#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [7, 8]}}
{"token": ["Unlike", "the", "C0031727#ent", "<e1>", "purified", "homologous", "NI", "kinase", "did", "not", "phosphorylate", "C0035681#ent", "<e2>", ",", "as", "a", "result", ",", "did", "not", "alter", "transcription", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [11, 12]}}
{"token": ["Cells", "containing", "the", "C1564139#ent", "<e1>", "able", "to", "regulate", "normally", "the", "production", "of", "OmpF", "and", "C0755857#ent", "<e2>", "in", "response", "to", "changes", "in", "osmolarity", "."], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0755857", "name": "C0755857#ent", "pos": [14, 15]}}
{"token": ["On", "the", "basis", "of", "the", "discovery", "that", "the", "leukemogenic", "gene", "C1333922#ent", "<e1>", "can", "also", "expand", "hematopoietic", "stem", "cells", "we", "compared", "the", "ability", "of", "C1840524#ent", "<e2>", "that", "of", "HOXB4", "to", "trigger", "HSC", "expansion", "in", "vitro"], "h": {"id": "C1333922", "name": "C1333922#ent", "pos": [10, 11]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1840524", "name": "C1840524#ent", "pos": [23, 24]}}
{"token": ["DYT1", "C3888090#ent", "<e1>", "an", "autosomal", "dominant", "movement", "disorder", "due", "to", "a", "3-bp", "C0017346#ent", "<e2>", "deletion", "in", "the", "TOR1A", "gene", "which", "becomes", "manifest", "in", "only", "30", "-", "40", "%", "of", "mutation", "carriers", "."], "h": {"id": "C3888090", "name": "C3888090#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [12, 13]}}
{"token": ["C3888090#ent", "<e1>", "caused", "by", "a", "single", "C0017346#ent", "<e2>", "deletion", "in", "exon", "5", "TOR1A", ",", "the", "gene", "encoding", "torsinA", ",", "a", "putative", "chaperone", "protein"], "h": {"id": "C3888090", "name": "C3888090#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017346", "name": "C0017346#ent", "pos": [6, 7]}}
{"token": ["The", "character", "of", "the", "usual", "C0162823#ent", "<e1>", "to", "that", "of", "an", "C0162820#ent", "<e2>"], "h": {"id": "C0162823", "name": "C0162823#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162820", "name": "C0162820#ent", "pos": [11, 12]}}
{"token": ["C0268487#ent", "<e1>", "of", "another", "factor", ",", "C1416681#ent", "<e2>", ",", "were", "detected", "with", "a", "human", "prekallikrein-deficient", "plasma", "(", "16", "and", "6", "U/dl", ",", "control", "population", "to", "173", "U/dl", ")", "."], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416681", "name": "C1416681#ent", "pos": [6, 7]}}
{"token": ["Merkel", "cells", "sinus", "hair", "follicles", "nude", "mice", "investigated", "by", "fluorescence", "and", "electron", "microscopy", "pretreatment", "with", "amine", "precursors", "L-Dopa", ",", "C4083155#ent", "<e1>", ")", "and", "monoaminoxidase-inhibitors", "(", "Marsilid", ",", "C0018602#ent", "<e2>", ")", "."], "h": {"id": "C4083155", "name": "C4083155#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0018602", "name": "C0018602#ent", "pos": [27, 28]}}
{"token": ["Here", ",", "we", "examined", "the", "efficacy", "of", "intraventricular", "injection", "of", "a", "recombinant", "adenovirus-expressing", "heparin-binding", "epidermal", "growth", "factor-like", "growth", "factor", "(", "C1704816#ent", "<e1>", ")", "on", "neurogenesis", ",", "angiogenesis", ",", "and", "functional", "outcome", "C0007785#ent", "<e2>"], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0007785", "name": "C0007785#ent", "pos": [31, 32]}}
{"token": ["The", "preliminary", "findings", "of", "this", "study", "suggest", "that", "C0076829#ent", "<e1>", "is", "very", "effective", "against", "C0014549#ent", "<e2>", "alcohol", "withdrawal", "syndrome"], "h": {"id": "C0076829", "name": "C0076829#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0014549", "name": "C0014549#ent", "pos": [14, 15]}}
{"token": ["The", "C0022658#ent", "<e1>", "presents", "as", "rapidly", "progressive", "renal", "failure", "C0027697#ent", "<e2>", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0027697", "name": "C0027697#ent", "pos": [9, 10]}}
{"token": ["They", "suffered", "from", "invasive", "aspergillosis", "C0149521#ent", "<e1>", "pseudocyst", "formation", ",", "and", "acute", "pancreatitis", "with", "C0078911#ent", "<e2>"], "h": {"id": "C0149521", "name": "C0149521#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0078911", "name": "C0078911#ent", "pos": [14, 15]}}
{"token": ["TRK-fused", "gene", "TFG", ")", "was", "first", "identified", "as", "a", "partner", "of", "C0919487#ent", "<e1>", "in", "generating", "the", "C1420703#ent", "<e2>", "and", "is", "also", "involved", "in", "oncogenic", "rearrangements", "ALK", "in", "anaplastic", "lymphoma", "NOR1", "in", "mixoid", "chondrosarcoma"], "h": {"id": "C0919487", "name": "C0919487#ent", "pos": [11, 12]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1420703", "name": "C1420703#ent", "pos": [16, 17]}}
{"token": ["The", "predicted", "amino", "acid", "sequence", "the", "C0216991#ent", "<e1>", "very", "few", "changes", "when", "compared", "to", "the", "C0014442#ent", "<e2>", "82", "%", "of", "the", "residues", "are", "identical", ")", "."], "h": {"id": "C0216991", "name": "C0216991#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["Marked", "C0001622#ent", "<e1>", "of", "oxalate", "by", "hepatic", "cells", "in", "the", "C0020500#ent", "<e2>", "responsible", "for", "clinical", "features", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0020500", "name": "C0020500#ent", "pos": [10, 11]}}
{"token": ["Finally", ",", "N-terminal", "amino", "acid", "sequencing", "C1704867#ent", "<e1>", "purified", "from", "Day", "15", "pregnant", "C0016382#ent", "<e2>", "the", "secreted", "form", "of", "C1704867#ent", "<e1>", "mRNA", "."], "h": {"id": "C0016382", "name": "C0016382#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704867", "name": "C1704867#ent", "pos": [6, 7]}}
{"token": ["The", "increase", "of", "C1421451#ent", "<e1>", "expression", "was", "also", "observed", "by", "adding", "with", "C3495555#ent", "<e2>", "related", "dipeptides", ",", "N-acetylcarnosine", "and", "anserine", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3495555", "name": "C3495555#ent", "pos": [12, 13]}}
{"token": ["Sanyanusin", "et", "al.", "have", "identified", "frameshift", "mutations", "exon", "5", "PAX2", "in", "several", "patients", "with", "C1852759#ent", "<e1>", "which", "involved", "C0042580#ent", "<e2>", "as", "part", "of", "the", "phenotype", "."], "h": {"id": "C1852759", "name": "C1852759#ent", "pos": [14, 15]}, "relation": "has_manifestation", "t": {"id": "C0042580", "name": "C0042580#ent", "pos": [18, 19]}}
{"token": ["C0272126#ent", "<e1>", "an", "unusual", "illness", "of", "autoimmune", "etiology", "characterized", "by", "C1839163#ent", "<e2>", "and", "hemolytic", "anemia"], "h": {"id": "C0272126", "name": "C0272126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [10, 11]}}
{"token": ["Gel", "mobility", "assays", "that", "both", "A1", "and", "C1417326#ent", "<e1>", "bind", "TRs", "in", "the", "presence", "of", "C0919499#ent", "<e2>", "auxiliary", "proteins", "the", "retinoid", "X", "beta", "receptor"], "h": {"id": "C1417326", "name": "C1417326#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0919499", "name": "C0919499#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "we", "also", "found", "that", "PP1", "and", "LY294002", ",", "but", "not", "C0298346#ent", "<e1>", "inhibit", "the", "C4049859#ent", "<e2>", "promoter", "activity"], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [16, 17]}}
{"token": ["The", "C0521622#ent", "<e1>", "brought", "on", "by", "urinary", "retention", "by", "a", "C0005697#ent", "<e2>"], "h": {"id": "C0521622", "name": "C0521622#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0005697", "name": "C0005697#ent", "pos": [10, 11]}}
{"token": ["C0036323#ent", "<e1>", "is", "a", "parasitic", "C1112211#ent", "<e2>", "is", "known", "to", "affect", "many", "aspects", "of", "drug", "metabolism"], "h": {"id": "C0036323", "name": "C0036323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1112211", "name": "C1112211#ent", "pos": [5, 6]}}
{"token": ["We", "studied", "the", "environmental", "regulation", "the", "Synechocystis", "sp.", "PCC", "6803", "deg", "genes", "at", "the", "level", "of", "transcription", "and", "C0175168#ent", "<e1>", "the", "gene", "products", "evaluate", "their", "hypothetical", "role", "in", "C1538716#ent", "<e2>", "."], "h": {"id": "C0175168", "name": "C0175168#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1538716", "name": "C1538716#ent", "pos": [28, 29]}}
{"token": ["The", "antitumor", "effects", "combination", "chemotherapies", "CDDP", "and", "the", "C0006812#ent", "<e1>", "CPT-11", "were", "compared", "with", "those", "of", "C0042672#ent", "<e2>", "podophyllotoxins", ",", "and", "those", "of", "CPT-11", "and", "cisplatinum", "analogues", "were", "also", "estimated", "."], "h": {"id": "C0006812", "name": "C0006812#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042672", "name": "C0042672#ent", "pos": [16, 17]}}
{"token": ["A", "genotype/phenotype", "correlation", "study", "that", "the", "C0442874#ent", "<e1>", "segregates", "with", "the", "duplication", "and", "that", "the", "C2917660#ent", "<e2>", "substitution", "does", "not", "seem", "to", "modify", "the", "clinical", "characteristics", "the", "severity", "of", "the", "peripheral", "neuropathy"], "h": {"id": "C0442874", "name": "C0442874#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [15, 16]}}
{"token": ["2", ")", "Slow", "inactivation", "--", "a", "physiological", "mechanism", "to", "suppress", "ectopic", "activity", "response", "to", "slow", "shifts", "in", "membrane", "potential", "increases", "binding", "affinity", "for", "C0162792#ent", "<e1>", ",", "fentanyl", "and", "C2350083#ent", "<e2>", "."], "h": {"id": "C0162792", "name": "C0162792#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2350083", "name": "C2350083#ent", "pos": [28, 29]}}
{"token": ["Germin-like", "proteins", "GLPs", ")", "are", "ubiquitous", "C0032089#ent", "<e1>", "encoded", "by", "diverse", "C0017363#ent", "<e2>"], "h": {"id": "C0032089", "name": "C0032089#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [11, 12]}}
{"token": ["Phorbol", ",", "an", "analogue", "of", "C0256103#ent", "<e1>", "with", "neither", "tumor-promoting", "nor", "differentiation-inhibitory", "activity", "did", "not", "induce", "C2347319#ent", "<e2>", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2347319", "name": "C2347319#ent", "pos": [16, 17]}}
{"token": ["Cidofovir", ",", "pamidronic", "acid", "C0038760#ent", "<e1>", ",", "rifabutin", "and", "C0041030#ent", "<e2>", "'", "probably", "'", "cause", "uveitis", "."], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041030", "name": "C0041030#ent", "pos": [9, 10]}}
{"token": ["Cultures", "from", "the", "C1706113#ent", "<e1>", "null", "mice", "expressed", "higher", "levels", "of", "mRNA", "encoding", "DKK1", "and", "C3541991#ent", "<e2>", "than", "did", "the", "wild-type", "cultures", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541991", "name": "C3541991#ent", "pos": [15, 16]}}
{"token": ["To", "address", "whether", "the", "increased", "adipogenesis", "observed", "in", "the", "C1706113#ent", "<e1>", "null", "cultures", "associated", "with", "inhibition", "of", "the", "canonical", "Wnt", "signaling", "pathway", "mRNA", "levels", "DKK1", "and", "C3541991#ent", "<e2>", "were", "examined", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3541991", "name": "C3541991#ent", "pos": [26, 27]}}
{"token": ["Client", "proteins", "of", "C3273507#ent", "<e1>", "include", "many", "C3889446#ent", "<e2>", "or", "mutated", "oncogenes", "that", "are", "known", "to", "be", "critical", "for", "the", "transformed", "phenotype", "observed", "in", "tumors", "."], "h": {"id": "C3273507", "name": "C3273507#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [7, 8]}}
{"token": ["Using", "cotransfection", "assays", "in", "P19", "embryonal", "carcinoma", "cells", "we", "show", "that", "NF-L", "promoter", "fragments", "to", "the", "C0008169#ent", "<e1>", "be", "trans-activated", "by", "expression", "vectors", "encoding", "FOS", "and", "JUN", "(", "C0162508#ent", "<e2>", ")", "and", "by", "Krox-24", "protein"], "h": {"id": "C0008169", "name": "C0008169#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [28, 29]}}
{"token": ["The", "viral", "proteins", "such", "as", "Tat", ",", "C0017343#ent", "<e1>", ",", "and", "Nef", ",", "are", "associated", "with", "C1337091#ent", "<e2>", "the", "continuous", "induction", "apoptotic", "factors"], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [16, 17]}}
{"token": ["Additionally", ",", "AM251", "administered", "alone", ",", "in", "the", "absence", "of", "exogenous", "cannabinoid", "agonists", "inhibited", "C1705518#ent", "<e1>", "release", "demonstrating", "the", "role", "of", "endogenous", "C2347556#ent", "<e2>", "in", "C1705518#ent", "<e1>", "release", "."], "h": {"id": "C1705518", "name": "C1705518#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2347556", "name": "C2347556#ent", "pos": [22, 23]}}
{"token": ["Oxitropium", "bromide", "Oxivent", ")", ",", "an", "C0354764#ent", "<e1>", "inhibits", "coughing", "induced", "by", "hypotonic", "aerosols", "in", "both", "C0004096#ent", "<e2>", "and", "non-asthmatic", "individuals", "."], "h": {"id": "C0354764", "name": "C0354764#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["We", "report", "three", "examples", "of", "community-acquired", "toxigenic", "C0235952#ent", "<e1>", "elderly", "patients", "who", "had", "neither", "received", "C1136254#ent", "<e2>", "been", "institutionalised", "."], "h": {"id": "C0235952", "name": "C0235952#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [15, 16]}}
{"token": ["After", "infection", "with", "Mycoplasma", "hyorhinis", "HIR", "developed", "more", "severe", "C0029408#ent", "<e1>", "and", "less", "C0151859#ent", "<e2>", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151859", "name": "C0151859#ent", "pos": [13, 14]}}
{"token": ["The", "most", "common", "autonomic", "symptoms", "MS", "are", "disorders", "of", "micturation", ",", "C0242350#ent", "<e1>", ",", "sudomotor", "and", "gastrointestinal", "disturbances", "orthostatic", "intolerance", "well", "as", "C0037317#ent", "<e2>"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037317", "name": "C0037317#ent", "pos": [22, 23]}}
{"token": ["The", "SGS1", "of", "Saccharomyces", "cerevisiae", "a", "C1334043#ent", "<e1>", "of", "the", "C0005859#ent", "<e2>", "Werner's", "syndrome", "genes", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005859", "name": "C0005859#ent", "pos": [10, 11]}}
{"token": ["In", "animals", ",", "genes", "that", "are", "C1334043#ent", "<e1>", "to", "RecQ", "protein", "such", "as", "the", "human", "genes", "for", "C0005859#ent", "<e2>", "Werner's", "syndrome", "may", "also", "function", "in", "PTGS", "."], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0005859", "name": "C0005859#ent", "pos": [17, 18]}}
{"token": ["C1319018#ent", "<e1>", "be", "the", "first", "sign", "of", "C0004096#ent", "<e2>"], "h": {"id": "C1319018", "name": "C1319018#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [7, 8]}}
{"token": ["iii", ")", "Phosphorylation", "of", "the", "soluble", "inositol", "phosphodiesters", "GPI", ",", "C1417215#ent", "<e1>", ",", "and", "GPIP2", "enhances", "C3810542#ent", "<e2>", "delta1", "activity", "by", "dramatically", "increasing", "kcat", "and", "decreasing", "Km", "."], "h": {"id": "C1417215", "name": "C1417215#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3810542", "name": "C3810542#ent", "pos": [16, 17]}}
{"token": ["Our", "data", "suggest", "that", "C0913506#ent", "<e1>", "may", "be", "a", "promising", "and", "effective", "drug", "to", "treat", "C0008780#ent", "<e2>", "scleroderma", "."], "h": {"id": "C0913506", "name": "C0913506#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0008780", "name": "C0008780#ent", "pos": [15, 16]}}
{"token": ["Our", "data", "indicate", "that", ",", "in", "addition", "to", "MMP", "activities", ",", "suppression", "of", "C3889469#ent", "<e1>", "biosynthesis", "may", "contribute", "to", "the", "C0003486#ent", "<e2>", "pathogenesis", "because", "local", "LOX", "gene", "prevented", "C0003486#ent", "<e2>", "formation", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [20, 21]}}
{"token": ["The", "C0003308#ent", "<e1>", "econazole", "and", "C0009074#ent", "<e2>", "are", "known", "cytochrome", "P450", "enzyme", "inhibitors"], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0009074", "name": "C0009074#ent", "pos": [5, 6]}}
{"token": ["There", "is", "a", "good", "correlation", "between", "the", "results", "for", "C1335803#ent", "<e1>", "tests", "on", "a", "variety", "of", "C0072735#ent", "<e2>", ",", "phenols", "and", "isothiazolinones", ",", "and", "the", "corresponding", "data", "based", "on", "Draize", "tests", "."], "h": {"id": "C1335803", "name": "C1335803#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0072735", "name": "C0072735#ent", "pos": [16, 17]}}
{"token": ["Because", "drug", "therapy", "diabetes", "mellitus", "hypertension", "is", "capable", "of", "producing", "C0023656#ent", "<e1>", "the", "oral", "mucosa", "the", "question", "arises", "as", "to", "whether", "C1306792#ent", "<e2>", "an", "iatrogenically", "induced", "syndrome", "."], "h": {"id": "C0023656", "name": "C0023656#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1306792", "name": "C1306792#ent", "pos": [21, 22]}}
{"token": ["These", "results", "suggest", "that", "axonal", "C1826396#ent", "<e1>", "are", "not", "an", "exacerbating", "factor", "in", "C0085084#ent", "<e2>", "by", "mutant", "SOD1", "and", "that", "perikaryal", "C1826396#ent", "<e1>", "may", "even", "have", "beneficial", "effects", "."], "h": {"id": "C0085084", "name": "C0085084#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1826396", "name": "C1826396#ent", "pos": [5, 6]}}
{"token": ["An", "involvement", "of", "strychnine", "sensitive", "C0242901#ent", "<e1>", "receptor-mediated", "events", "in", "the", "mechanism", "of", "the", "anticonvulsive", "activity", "C0242909#ent", "<e2>", "valproate", "may", "be", "postulated", "."], "h": {"id": "C0242901", "name": "C0242901#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242909", "name": "C0242909#ent", "pos": [16, 17]}}
{"token": ["The", "Src", "family", "pathway", "the", "TLR9-MyD88", "pathway", "by", "promoting", "the", "tyrosine", "phosphorylation", "C1423633#ent", "<e1>", "and", "the", "recruitment", "of", "C1335892#ent", "<e2>", "to", "this", "receptor", "."], "h": {"id": "C1423633", "name": "C1423633#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "C0000294#ent", "<e1>", "was", "susceptible", "to", "degradation", "by", "pronase", ",", "C0752243#ent", "<e2>", "and", "proteinase", "K", "gave", "a", "different", "peptide", "profile", "from", "that", "of", "the", "PAS-O", "glycoprotein", "of", "human", "milk", "."], "h": {"id": "C0000294", "name": "C0000294#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752243", "name": "C0752243#ent", "pos": [11, 12]}}
{"token": ["The", "authors", "conclude", "that", "the", "test", "formulation", "be", "considered", "bioequivalent", "with", "the", "reference", "with", "C0590743#ent", "<e1>", "and", "in", "the", "borderline", "of", "bioequivalence", "with", "C0004147#ent", "<e2>", "."], "h": {"id": "C0590743", "name": "C0590743#ent", "pos": [14, 15]}, "relation": "has_constitutional_part", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [23, 24]}}
{"token": ["SDS-polyacrylamide", "gel", "electrophoresis", "Western", "blot", "analysis", "only", "one", "immunoreactive", "protein", "corresponding", "to", "the", "molecular", "weight", "C3812647#ent", "<e1>", "present", "in", "the", "soluble", "fraction", "after", "C3810542#ent", "<e2>", "treatment", "."], "h": {"id": "C3812647", "name": "C3812647#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3810542", "name": "C3810542#ent", "pos": [23, 24]}}
{"token": ["The", "viruses", "responsible", "for", "C0007684#ent", "<e1>", "easily", "detected", "with", "various", "C0009450#ent", "<e2>", "and", "serial", "patterns", "of", "herpesviruses", ",", "by", "this", "consensus", "primer-based", "PCR", "method", "."], "h": {"id": "C0007684", "name": "C0007684#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [10, 11]}}
{"token": ["Port-wine", "stains", "from", "a", "C0042373#ent", "<e1>", "than", "a", "C0027868#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [8, 9]}}
{"token": ["C0002699#ent", "<e1>", "is", "safe", "and", "effective", "therapy", "for", "patients", "with", "acute", "leukemia", "C0018824#ent", "<e2>"], "h": {"id": "C0002699", "name": "C0002699#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018824", "name": "C0018824#ent", "pos": [12, 13]}}
{"token": ["The", "mitogen-activated", "protein", "kinase/ERK", "MEK", ")", "inhibitor", "C0298346#ent", "<e1>", "as", "well", "as", "native", "laminin", "and", "C0527359#ent", "<e2>", "laminin-derived", "peptide", "prevented", "that", "downregulation", "."], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0527359", "name": "C0527359#ent", "pos": [15, 16]}}
{"token": ["The", "CMC", "of", "C0133689#ent", "<e1>", "4.4", "times", "larger", "than", "that", "of", "C0077539#ent", "<e2>", "."], "h": {"id": "C0133689", "name": "C0133689#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0077539", "name": "C0077539#ent", "pos": [11, 12]}}
{"token": ["Cumulative", "C0004093#ent", "<e1>", "resulted", "in", "C3273706#ent", "<e2>", "at", "7.0", "g", "m(-2", ")", "."], "h": {"id": "C0004093", "name": "C0004093#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3273706", "name": "C3273706#ent", "pos": [5, 6]}}
{"token": ["The", "C0013227#ent", "<e1>", "sulfadoxine", "and", "C0034283#ent", "<e2>", "are", "commonly", "used", "to", "treat", "Plasmodium", "falciparum", "malaria", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [5, 6]}}
{"token": ["To", "identify", "the", "most", "appropriate", "dose", "of", "C0016277#ent", "<e1>", "for", "the", "treatment", "of", "symptomatic", "fungal", "C0042029#ent", "<e2>", "UTI", ")", "."], "h": {"id": "C0016277", "name": "C0016277#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [15, 16]}}
{"token": ["The", "potency", "order", "of", "C1866257#ent", "<e1>", "constructs", "for", "activation", "of", "C1413365#ent", "<e2>", "(", "cGK", "II", "membrane-bound", "cGK", "I", "chimer", ">", ">"], "h": {"id": "C1866257", "name": "C1866257#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413365", "name": "C1413365#ent", "pos": [10, 11]}}
{"token": ["C1-inhibitor", "inhibited", "MASP-2", "50-fold", "faster", "than", "C1412937#ent", "<e1>", "and", "much", "faster", "than", "any", "other", "C1947941#ent", "<e2>", "tested", "to", "date", ",", "implying", "that", "MASP-2", "is", "a", "major", "physiological", "target", "of", "C1-inhibitor", "."], "h": {"id": "C1412937", "name": "C1412937#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [14, 15]}}
{"token": ["These", "data", "suggest", "that", "C3538705#ent", "<e1>", "may", "inhibit", "mitochondrial", "COX", "by", "forming", "adducts", "with", "the", "C0014442#ent", "<e2>", ",", "and", "that", "this", "could", "be", "one", "mechanism", "underlying", "mitochondrial", "damage", "by", "oxidative", "stress"], "h": {"id": "C3538705", "name": "C3538705#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["alpha", "1PI", "and", "eglin", "C", "elastin", "solubilization", "largely", "by", "enhancing", "net", "dissociation", "of", "C3538705#ent", "<e1>", "from", "the", "complexes", ";", "C0014442#ent", "<e2>", "remaining", "bound", "to", "the", "substrate", "retained", "essentially", "full", "activity", "."], "h": {"id": "C3538705", "name": "C3538705#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "there", "was", "a", "decrease", "in", "C1705610#ent", "<e1>", "mRNA", "levels", "despite", "an", "increase", "in", "C1412126#ent", "<e2>", "RNA-binding", "activity", "a", "marked", "increase", "in", "inducible", "nitric", "oxide", "synthase", "mRNA", "expression", "."], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412126", "name": "C1412126#ent", "pos": [15, 16]}}
{"token": ["5", ")", "The", "parallel", "induction", "of", "C1412104#ent", "<e1>", "of", "ATP", "citrate", "lyase", "a", "co-ordinate", "long-term", "regulation", "of", "lipogenic", "C3540790#ent", "<e2>", "."], "h": {"id": "C1412104", "name": "C1412104#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [18, 19]}}
{"token": ["Using", "4", "human", "cancer", "cell", "lines", "the", "relevance", "of", "C0068355#ent", "<e1>", ":", "quinone", "oxidoreductase", "DT-diaphorase", ")", "activity", "to", "C0026254#ent", "<e2>", "cytotoxicity", "was", "investigated", "."], "h": {"id": "C0068355", "name": "C0068355#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0026254", "name": "C0026254#ent", "pos": [18, 19]}}
{"token": ["Interaction", "studies", "unique", "epigenetic", "regulatory", "complexes", "associated", "with", "H3-K4", "methylation", "in", "the", "testis", ",", "including", "the", "association", "of", "C1428785#ent", "<e1>", "and", "methyl-CpG-binding", "domain", "protein", "2", "MBD2a/b", ")", "in", "a", "complex", "with", "C1333891#ent", "<e2>", "HDAC1", ")", "."], "h": {"id": "C1428785", "name": "C1428785#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1333891", "name": "C1333891#ent", "pos": [31, 32]}}
{"token": ["Activating", "transcription", "factor", "3", "ATF3", ")", "is", "a", "basic", "C1423111#ent", "<e1>", "is", "highly", "C1512488#ent", "<e2>", "to", "c-Jun", "dimerization", "protein", "2", "JDP2", ")", ",", "especially", "within", "the", "threonine/proline", "phosphoacceptor", "site", ",", "Thr-148", "."], "h": {"id": "C1423111", "name": "C1423111#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [13, 14]}}
{"token": ["Before", "first", "sampling", "a", "moderate", "C0162316#ent", "<e1>", "10.3", "g.dL-1", ")", "was", "treated", "with", "mg", "of", "intravenous", "C0060241#ent", "<e2>"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0060241", "name": "C0060241#ent", "pos": [16, 17]}}
{"token": ["In", "the", "yeast", "Saccharomyces", "cerevisiae", "two", "C4283758#ent", "<e1>", "glutamate", "dehydrogenases", "NADP-GDHs", ")", "encoded", "by", "GDH1", "and", "C3274756#ent", "<e2>", "catalyze", "the", "synthesis", "of", "glutamate", "from", "ammonium", "and", "alpha-ketoglutarate", "."], "h": {"id": "C4283758", "name": "C4283758#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3274756", "name": "C3274756#ent", "pos": [16, 17]}}
{"token": ["Association", "of", "polymorphism", "of", "b1-adrenoreceptors", "gene", "and", "cytochrome", "2D6", "gene", "efficacy", "of", "b-adrenoblocker", "C0543470#ent", "<e1>", "was", "studied", "in", "81", "patients", "with", "I", "and", "C3273406#ent", "<e2>", "degree", "arterial", "hypertension", "."], "h": {"id": "C0543470", "name": "C0543470#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [23, 24]}}
{"token": ["Because", "p27", "protein", "been", "shown", "to", "be", "abnormally", "expressed", "both", "in", "dysplasia", "associated", "with", "Barrett's", "esophagus", "in", "sporadic", "colorectal", "adenomas", "we", "used", "immunohistochemistry", "to", "evaluate", "C1420433#ent", "<e1>", "expression", "in", "C0021390#ent", "<e2>", "dysplasia", "and", "carcinomas", "."], "h": {"id": "C1420433", "name": "C1420433#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [29, 30]}}
{"token": ["Whereas", "myalgias", "are", "ubiquitous", "in", "C0023364#ent", "<e1>", "and", "most", "patients", "show", "mildly", "elevated", "muscle", "C3540790#ent", "<e2>", ",", "life-threatening", "rhabdomyolysis", "is", "rare", "."], "h": {"id": "C0023364", "name": "C0023364#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "C0085222#ent", "<e1>", "a", "very", "rare", "complication", "of", "C0022104#ent", "<e2>", "in", "patients", "seen", "at", "our", "institution", "."], "h": {"id": "C0085222", "name": "C0085222#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [9, 10]}}
{"token": ["FDG", "PET/CT", "clearly", "demonstrated", "a", "C2947985#ent", "<e1>", "the", "atlantoaxial", "area", "suggesting", "high", "metabolic", "activity", "C1739148#ent", "<e2>", "."], "h": {"id": "C2947985", "name": "C2947985#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1739148", "name": "C1739148#ent", "pos": [14, 15]}}
{"token": ["The", "expression", "of", "ABCA1", "and", "SR-BI", "was", "inhibited", "by", "the", "PXR", "activators", "rifampicin", "and", "lithocholic", "acid", "LCA", ")", "in", "HepG2", "cells", "pregnenolone", "16alpha-carbonitrile", "C1826553#ent", "<e1>", ")", "in", "primary", "rat", "C0669372#ent", "<e2>", "."], "h": {"id": "C1826553", "name": "C1826553#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [29, 30]}}
{"token": ["Kininogens", "'", "C0002313#ent", "<e1>", "inhibitory", "activity", "exists", "in", "intact", "kininogens", ",", "C1537501#ent", "<e2>", ",", "and", "all", "of", "BK", "'s", "breakdown", "products", "."], "h": {"id": "C0002313", "name": "C0002313#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [11, 12]}}
{"token": ["The", "efficacy", "and", "safety", "of", "C0127615#ent", "<e1>", "enema", "were", "examined", "in", "20", "patients", "with", "C3266102#ent", "<e2>", "or", "dependent", ",", "distal", "ulcerative", "colitis"], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3266102", "name": "C3266102#ent", "pos": [14, 15]}}
{"token": ["We", "describe", "a", "patient", "who", "had", "an", "immediate", ",", "intense", ",", "localized", "C0039103#ent", "<e1>", "due", "to", "C0040866#ent", "<e2>", "injection", "."], "h": {"id": "C0039103", "name": "C0039103#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0040866", "name": "C0040866#ent", "pos": [16, 17]}}
{"token": ["But", "a", "minority", "of", "underlying", "diseases", "(", "angiokeratoma", "corporis", "diffusum", "C1413864#ent", "<e1>", "diabetes", "mellitus", "galactosemia", ",", "hypocalcemia", ",", "Refsum's", "disease", "Wilson's", "disease", "Charles", "Bonnet", "syndrome", "relapsing", "C0031053#ent", "<e2>", ";", "adverse", "effects", "medication", "and", "intoxications", ")", "can", "be", "treated", "causally", "."], "h": {"id": "C1413864", "name": "C1413864#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031053", "name": "C0031053#ent", "pos": [26, 27]}}
{"token": ["Overexpression", "of", "C1705323#ent", "<e1>", ",", "one", "of", "the", "COX", "C0026794#ent", "<e2>", ",", "has", "been", "shown", "to", "be", "an", "early", "event", "lung", "carcinogenesis", "may", "play", "an", "important", "role", "in", "lung", "cancer", "development", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026794", "name": "C0026794#ent", "pos": [9, 10]}}
{"token": ["The", "AMPA/cyclothiazide", "stimulation", "was", "blocked", "by", "C0099122#ent", "<e1>", "and", "by", "C0062021#ent", "<e2>", "an", "antagonist", "at", "the", "cyclothiazide", "site"], "h": {"id": "C0099122", "name": "C0099122#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0062021", "name": "C0062021#ent", "pos": [10, 11]}}
{"token": ["Neither", "the", "duration", "(", "35", "+", "/-", "10", "to", "39", "+", "/-", "13", "ms", ")", "nor", "the", "composition", "of", "the", "C0857393#ent", "<e1>", "gap", "changed", "on", "C1254351#ent", "<e2>", "."], "h": {"id": "C0857393", "name": "C0857393#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [25, 26]}}
{"token": ["Some", "studies", "have", "reported", "the", "effectiveness", "of", "pharmacologic", "therapies", "calcium", "antagonists", "C0001645#ent", "<e1>", ")", "in", "facilitating", "C0041952#ent", "<e2>", "expulsion", "after", "ESWL", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041952", "name": "C0041952#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "neither", "C3713294#ent", "<e1>", "methionine", "adenosyl-transferase", "significantly", "associated", "with", "C3179066#ent", "<e2>", ",", "and", "only", "a", "small", "proportion", "of", "the", "C3713294#ent", "<e1>", "associated", "with", "mitochondrial", "fraction"], "h": {"id": "C3179066", "name": "C3179066#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3713294", "name": "C3713294#ent", "pos": [4, 5]}}
{"token": ["These", "features", "make", "the", "fly", "an", "ideal", "system", "to", "analyse", "the", "role", "of", "the", "C3889135#ent", "<e1>", "family", "and", "to", "identify", "genes", "in", "the", "C2700049#ent", "<e2>", "pathway", "."], "h": {"id": "C3889135", "name": "C3889135#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2700049", "name": "C2700049#ent", "pos": [23, 24]}}
{"token": ["Using", "a", "novel", "methodology", "capable", "of", "C1456390#ent", "<e1>", "miRNA", "expression", "in", "small", "numbers", "of", "primary", "cells", "we", "identify", "C3811719#ent", "<e2>", "as", "preferentially", "expressed", "in", "the", "megakaryocytic", "lineage", "."], "h": {"id": "C1456390", "name": "C1456390#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3811719", "name": "C3811719#ent", "pos": [18, 19]}}
{"token": ["These", "studies", "show", "that", "the", "regulation", "of", "synaptic", "Ras", "signaling", "C1420546#ent", "<e1>", "is", "important", "for", "proper", "neuronal", "development", "C1415287#ent", "<e2>", "trafficking", "and", "is", "critical", "for", "the", "induction", "of", "LTP", "."], "h": {"id": "C1420546", "name": "C1420546#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1415287", "name": "C1415287#ent", "pos": [18, 19]}}
{"token": ["We", "identified", "2", "clinical", "C1875400#ent", "<e1>", "of", "E.", "coli", "produced", "the", "plasmid-mediated", "AmpC", "enzyme", "C0532996#ent", "<e2>"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0532996", "name": "C0532996#ent", "pos": [14, 15]}}
{"token": ["3-Hydroxykynurenine", "is", "condensed", "to", "C0043325#ent", "<e1>", "by", "cytochrome", "c", "cytochrome", "oxidase", "rat", "C0023899#ent", "<e2>", "mitochondria", "."], "h": {"id": "C0043325", "name": "C0043325#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}}
{"token": ["Genetic", "tests", "an", "expanded", "C1706112#ent", "<e1>", "of", "24", "CAG", "repeats", "the", "C0752124#ent", "<e2>"], "h": {"id": "C1706112", "name": "C1706112#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752124", "name": "C0752124#ent", "pos": [11, 12]}}
{"token": ["C1424053#ent", "<e1>", "is", "a", "recently", "described", "C0017337#ent", "<e2>", "which", "is", "upregulated", "in", "murine", "stromal", "cells", "lining", "tumors"], "h": {"id": "C1424053", "name": "C1424053#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}}
{"token": ["The", "glycine-rich", "phosphate", "anchor", "of", "the", "nucleotide", "binding", "fold", "of", "the", "C0010536#ent", "<e1>", "a", "beta", "ribbon", "acting", "as", "a", "C1412362#ent", "<e2>", "with", "conformational", "flexibility", "over", "the", "triphosphate", "group", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412362", "name": "C1412362#ent", "pos": [19, 20]}}
{"token": ["The", "C0014544#ent", "<e1>", "that", "occurs", "in", "C0342783#ent", "<e2>", "a", "seizure", "phenotype", "similar", "to", "that", "occurring", "in", "the", "SSADH(-/-", ")", "mouse", "."], "h": {"id": "C0014544", "name": "C0014544#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0342783", "name": "C0342783#ent", "pos": [6, 7]}}
{"token": ["PATIENTS", "C2827389#ent", "<e1>", "METHODS", ":", "The", "characteristics", "of", "12", "cases", "of", "C0153188#ent", "<e2>", "diagnosed", "in", "our", "dermatology", "department", "June", "and", "December", "2004", "were", "studied", "."], "h": {"id": "C2827389", "name": "C2827389#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0153188", "name": "C0153188#ent", "pos": [11, 12]}}
{"token": ["Since", "THP-1", "cells", "interact", "with", "ICAM-1", "and", "FG", "through", "beta2", "integrins", "and", "with", "VCAM-1", "and", "C1706331#ent", "<e1>", "via", "beta1", "integrins", "regulation", "of", "C1704816#ent", "<e2>", "expression", "appears", "to", "be", "specific", "to", "beta1", "integrin", "ligation"], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704816", "name": "C1704816#ent", "pos": [22, 23]}}
{"token": ["Whereas", "L35", "cells", "do", "not", "express", "C1826328#ent", "<e1>", "MTP", ")", ",", "which", "regulates", "lipoprotein", "secretion", "they", "express", "C1413893#ent", "<e2>", ",", "which", "regulates", "bile", "acid", "synthesis", "from", "cholesterol", "."], "h": {"id": "C1826328", "name": "C1826328#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413893", "name": "C1413893#ent", "pos": [17, 18]}}
{"token": ["FAO", "cells", "display", "the", "opposite", "phenotype", "(", "i.e.", "expression", "of", "C1826328#ent", "<e1>", "but", "not", "C1413893#ent", "<e2>", ")", "."], "h": {"id": "C1826328", "name": "C1826328#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413893", "name": "C1413893#ent", "pos": [14, 15]}}
{"token": ["C0011777#ent", "<e1>", "or", "dexamethasone", "and", "C0009262#ent", "<e2>", "delivered", "via", "this", "system", ",", "however", ",", "failed", "to", "reduce", "the", "degree", "of", "intimal", "hyperplasia", "overstretch", "balloon", "injury", "to", "the", "rabbit", "carotid", "arteries"], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009262", "name": "C0009262#ent", "pos": [5, 6]}}
{"token": ["Our", "aim", "was", "to", "investigate", "possible", "effects", "of", "sequence", "variations", "in", "C3540577#ent", "<e1>", ",", "encoding", "the", "C1412077#ent", "<e2>", "MRP2", ")", ",", "on", "the", "pharmacokinetics", "of", "the", "MRP2", "substrate", "pravastatin", "."], "h": {"id": "C3540577", "name": "C3540577#ent", "pos": [11, 12]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412077", "name": "C1412077#ent", "pos": [16, 17]}}
{"token": ["Selective", "beta(3)-adrenoceptor", "agonists", "and", "antimuscarinics", "are", "potentially", "useful", "C0991617#ent", "<e1>", "for", "treating", "C0574785#ent", "<e2>", ",", "particularly", "for", "storage", "symptoms", "secondary", "to", "outflow", "obstruction"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0574785", "name": "C0574785#ent", "pos": [12, 13]}}
{"token": ["However", ",", "the", "viral", "protein", "a", "unique", "contact", ":", "a", "hydrogen", "bond", "network", "formed", "between", "C3812648#ent", "<e1>", "in", "LMP1", "and", "Tyr395", "and", "Arg393", "in", "C1420888#ent", "<e2>", "."], "h": {"id": "C3812648", "name": "C3812648#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420888", "name": "C1420888#ent", "pos": [24, 25]}}
{"token": ["In", "this", "study", "we", "examined", "whether", "the", "DOG1", "C0678941#ent", "<e1>", "as", "with", "the", "C1416655#ent", "<e2>", "PDGFRA", "gene"], "h": {"id": "C0678941", "name": "C0678941#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [13, 14]}}
{"token": ["C0010980#ent", "<e1>", "is", "used", "in", "dermatology", "to", "treat", "inflammatory", "dermatoses", "as", "C0011608#ent", "<e2>", "pyoderma", "gangrenosum", "and", "was", "formerly", "the", "treatment", "of", "choice", "for", "acne", "conglobata"], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011608", "name": "C0011608#ent", "pos": [11, 12]}}
{"token": ["4,4'-Diaminodiphenyl", "sulfone", "(", "dapsone", ",", "C0010980#ent", "<e1>", ")", "is", "highly", "effective", "in", "C0011608#ent", "<e2>", "immune", "complex", "disease", "which", "polymorphonuclear", "leukocytes", "PMN", ")", "play", "an", "important", "role", "."], "h": {"id": "C0010980", "name": "C0010980#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0011608", "name": "C0011608#ent", "pos": [12, 13]}}
{"token": ["Both", "C1947941#ent", "<e1>", "share", "similar", "structural", "organization", "a", "prodomain", ",", "a", "catalytic", "domain", "via", "C3253985#ent", "<e2>", "and", "DSG", "active", "site", "motifs", ",", "a", "single", "transmembrane", "domain", "and", "a", "short", "C-terminal", "tail"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3253985", "name": "C3253985#ent", "pos": [14, 15]}}
{"token": ["Both", "pineoblastoma", "and", "pineocytoma", "exhibited", "variable", "immunoreactivity", "to", "neurofilament", "proteins", "C1420554#ent", "<e1>", ",", "glial", "fibrillary", "acidic", "protein", "S-100", "protein", "retinal-S", "antigen", ",", "and", "C1419385#ent", "<e2>", ";", "the", "highest", "percentages", "of", "positive", "cells", "stained", "with", "C1420554#ent", "<e1>", "."], "h": {"id": "C1420554", "name": "C1420554#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [23, 24]}}
{"token": ["Clinically", "significant", "drug", "interactions", "been", "reported", "with", "C0674428#ent", "<e1>", "and", "indinavir", "and", "C0286737#ent", "<e2>", "."], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0286737", "name": "C0286737#ent", "pos": [12, 13]}}
{"token": ["Use", "of", "C0674428#ent", "<e1>", "in", "combination", "with", "C0286737#ent", "<e2>", "as", "the", "sole", "protease", "inhibitor", "not", "recommended", "."], "h": {"id": "C0674428", "name": "C0674428#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0286737", "name": "C0286737#ent", "pos": [7, 8]}}
{"token": ["The", "diagnostic", "survey", "usually", "limited", "to", "searching", "for", "acquired", "causes", "(", "C0037926#ent", "<e1>", "inflammatory", ",", "metabolic", ",", "infectious", "diseases", "and", "the", "so-called", "'", "C0037773#ent", "<e2>", "."], "h": {"id": "C0037926", "name": "C0037926#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0037773", "name": "C0037773#ent", "pos": [23, 24]}}
{"token": ["Among", "biological", "hazards", "are", "for", "instant", "C0043528#ent", "<e1>", "and", "ornithosis", ",", "Q-fever", ",", "C0041351#ent", "<e2>", "and", "tuberculosis", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0041351", "name": "C0041351#ent", "pos": [13, 14]}}
{"token": ["The", "present", "epidemiology", "of", "selected", "C0043528#ent", "<e1>", "brucellosis", ",", "anthrax", ",", "C0041351#ent", "<e2>", ",", "Q", "fever", "Chlamydia", "infections", "tuberculosis", ",", "respectively", "mycobacteriosis", "and", "EHEC", "infections", ",", "is", "discussed", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0041351", "name": "C0041351#ent", "pos": [11, 12]}}
{"token": ["One", "hundred", "and", "twenty", "patients", "with", "C0038358#ent", "<e1>", "who", "had", "been", "receiving", "maintenance", "treatment", "C0034665#ent", "<e2>", "(", "150", "or", "300", "mg/day", ")", "for", "periods", "up", "to", "7", "years", ",", "were", "studied", "retrospectively", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [6, 7]}, "relation": "may_be_prevented_by", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [14, 15]}}
{"token": ["Similar", "to", "other", "C0008679#ent", "<e1>", "personal", "factors", "play", "an", "important", "role", "in", "determining", "risk", "for", "C0007286#ent", "<e2>", "."], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007286", "name": "C0007286#ent", "pos": [15, 16]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "determine", "whether", "probenecid", "(PBD)-sensitive", "C1422678#ent", "<e1>", "the", "choroidal", "epithelium", "brain", "capillary", "endothelium", "involved", "in", "the", "clearance", "of", "C0042291#ent", "<e2>", "from", "the", "CNS", "of", "the", "rabbit", "."], "h": {"id": "C1422678", "name": "C1422678#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [24, 25]}}
{"token": ["Skeletal", "muscle", "three", "tropomyosin", "(", "Tm", ")", "isoforms", "from", "separate", "genes", ":", "alphaTm(fast)(alphaTm", ",", "TPM1", ")", ",", "betaTm", "(", "C1420873#ent", "<e1>", ")", ",", "and", "alphaTm(slow", ")", "(", "gammaTm", ",", "C1420874#ent", "<e2>", ")", "."], "h": {"id": "C1420873", "name": "C1420873#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420874", "name": "C1420874#ent", "pos": [29, 30]}}
{"token": ["Inclusion", "and", "exclusion", "criteria", "eighty-eight", "patients", "taking", "corticosteroids", "for", "at", "least", "two", "years", "who", "had", "not", "taken", "estrogen", "or", "C3541971#ent", "<e1>", "and", "had", "no", "causes", "of", "C0029456#ent", "<e2>"], "h": {"id": "C3541971", "name": "C3541971#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0029456", "name": "C0029456#ent", "pos": [26, 27]}}
{"token": ["C0912933#ent", "<e1>", "also", "attenuated", "phosphoinositide", "breakdown", "intracellular", "Ca(2+)", "elevation", "induced", "by", "C0009325#ent", "<e2>", ",", "arachidonic", "acid", "thrombin", "."], "h": {"id": "C0912933", "name": "C0912933#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [11, 12]}}
{"token": ["A", "method", "based", "on", "capillary", "electrophoresis", "electrochemical", "detection", "CE-ED", ")", "was", "developed", "for", "the", "simultaneous", "determination", "of", "C0000970#ent", "<e1>", "and", "C2917659#ent", "<e2>", "in", "the", "hydrolysates", "of", "C2917659#ent", "<e2>", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [17, 18]}, "relation": "structural_class_of", "t": {"id": "C2917659", "name": "C2917659#ent", "pos": [20, 21]}}
{"token": ["The", "possibility", "that", "C0000970#ent", "<e1>", "could", "be", "an", "attractive", "alternative", "to", "C2917659#ent", "<e2>", "in", "the", "clinic", "is", "discussed", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [3, 4]}, "relation": "structural_class_of", "t": {"id": "C2917659", "name": "C2917659#ent", "pos": [11, 12]}}
{"token": ["It", "was", "concluded", "that", "C0008402#ent", "<e1>", "is", "effective", "in", "preventing", "C0011991#ent", "<e2>", "induced", "by", "pelvic", "irradiation", "patients", "receiving", "a", "low", "fat", "diet", "is", "associated", "with", "side", "effects"], "h": {"id": "C0008402", "name": "C0008402#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [10, 11]}}
{"token": ["In", "two", "of", "three", "patients", "with", "C0001627#ent", "<e1>", "BH", ")", ",", "excretion", "of", "both", "C0038317#ent", "<e2>", "was", "normal", "."], "h": {"id": "C0001627", "name": "C0001627#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [14, 15]}}
{"token": ["It", "has", "been", "shown", "that", "prenatal", "C0022806#ent", "<e1>", "results", "at", "birth", "in", "increased", "concentration", "of", "C3887648#ent", "<e2>", "(", "NA", ")", "in", "the", "brain", "."], "h": {"id": "C0022806", "name": "C0022806#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [15, 16]}}
{"token": ["C2744579#ent", "<e1>", "hyperpolarization", "was", "enhanced", "in", "the", "presence", "of", "C1456349#ent", "<e2>", "and", "abolished", "after", "endothelium", "removal", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1456349", "name": "C1456349#ent", "pos": [9, 10]}}
{"token": ["Bile", "acids", "activate", "a", "nuclear", "receptor", "farnesoid", "X", "receptor", "FXR", ")", ",", "that", "induces", "C1412070#ent", "<e1>", "BSEP", ")", "but", "inhibits", "cholesterol", "7alpha-hydroxylase", "(", ")", "C0812327#ent", "<e2>", "the", "liver", "."], "h": {"id": "C1412070", "name": "C1412070#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0812327", "name": "C0812327#ent", "pos": [24, 25]}}
{"token": ["We", "propose", "that", "the", "UFO", "and", "ASK1", "proteins", "components", "of", "a", "C0077678#ent", "<e1>", "mediates", "the", "proteolysis", "of", "a", "repressor", "of", "C3537272#ent", "<e2>", "and", "PI", "expression", "."], "h": {"id": "C0077678", "name": "C0077678#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3537272", "name": "C3537272#ent", "pos": [20, 21]}}
{"token": ["All", "four", "proteases", "cleaved", "C0013352#ent", "<e1>", "proteins", "necessary", "for", "motility", ")", ",", "though", "treatment", "with", "C0041236#ent", "<e2>", "resulted", "in", "the", "most", "extensive", "solubilization", "of", "axonemal", "proteins"], "h": {"id": "C0013352", "name": "C0013352#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [15, 16]}}
{"token": ["We", "show", "that", "C1425034#ent", "<e1>", "binds", "to", "both", "Elipsa", "and", "C1417108#ent", "<e2>", ",", "suggesting", "that", "these", "proteins", "provide", "a", "bridging", "mechanism", "between", "the", "IFT", "particle", "and", "protein", "complexes", "assemble", "at", "the", "ciliary", "membrane"], "h": {"id": "C1425034", "name": "C1425034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417108", "name": "C1417108#ent", "pos": [10, 11]}}
{"token": ["C1706331#ent", "<e1>", "saturated", "with", "C0069678#ent", "<e2>", "hydrolysed", "at", "a", "higher", "rate", "by", "trypsin", ",", "cathepsin", "D", "thermolysin", "and", "pancreatic", "elastase", "native", "C1706331#ent", "<e1>", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0069678", "name": "C0069678#ent", "pos": [4, 5]}}
{"token": ["Western", "blot", "analysis", "a", "significant", "increase", "in", "the", "level", "of", "phosphorylated", "C3849574#ent", "<e1>", "(", "p-ERK", ")", "6", "hr", "after", "C0022614#ent", "<e2>", "injection", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [19, 20]}}
{"token": ["Using", "stable", "transfection", "techniques", "the", "estrogen", "receptor", "ER", ")", "expressing", "human", "endometrial", "cancer", "cell", "line", "C1823096#ent", "<e1>", ",", "was", "altered", "to", "also", "express", "both", "progesterone", "receptors", "C1418963#ent", "<e2>", ")", "."], "h": {"id": "C1823096", "name": "C1823096#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1418963", "name": "C1418963#ent", "pos": [26, 27]}}
{"token": ["To", "investigate", "the", "mechanisms", "regulating", "physiological", "and", "pathophysiological", "C1419867#ent", "<e1>", "expression", "we", "identified", "the", "core", "promoter", "of", "this", "C0017337#ent", "<e2>", "(", "SCN9A", ")", "in", "the", "human", "genome", "."], "h": {"id": "C1419867", "name": "C1419867#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [18, 19]}}
{"token": ["C1706006#ent", "<e1>", "induced", "cell", "death", "be", "inhibited", "by", "the", "C1516312#ent", "<e2>", "."], "h": {"id": "C1706006", "name": "C1706006#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516312", "name": "C1516312#ent", "pos": [9, 10]}}
{"token": ["Bartonella", "henselae", "infect", "humans", "resulting", "in", "a", "wide", "range", "of", "C0221163#ent", "<e1>", "cat-scratch", "disease", "fever", "with", "bacteremia", ",", "endocarditis", ",", "bacillary", "angiomatosis", "and", "C0030781#ent", "<e2>", "among", "others", "."], "h": {"id": "C0221163", "name": "C0221163#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030781", "name": "C0030781#ent", "pos": [23, 24]}}
{"token": ["Similar", "to", "anti-XyG", "antibodies", ",", "anti-bupleuran", "2IIC", ",", "a", "polyclonal", "antibody", "for", "galactosyl", "epitopes", "associated", "with", "C0070203#ent", "<e1>", ",", "stained", "all", "root", "epidermal", "cells", "both", "wild", "type", "C1413702#ent", "<e2>", "-", "1", "."], "h": {"id": "C0070203", "name": "C0070203#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413702", "name": "C1413702#ent", "pos": [27, 28]}}
{"token": ["Twelve", "tumors", "were", "treated", "with", "digesting", "C3541394#ent", "<e1>", "in", "order", "to", "isolate", "tumor-infiltrating", "lymphocytes", "well", "as", "tumor", "cells", "C1366477#ent", "<e2>", "were", "expanded", "by", "culture", "in", "the", "presence", "of", "human", "interleukin-2", "IL-2", ")", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366477", "name": "C1366477#ent", "pos": [18, 19]}}
{"token": ["C0126174#ent", "<e1>", "and", "CGP42112A", "together", "increased", "the", "actions", "of", "C1334081#ent", "<e2>", ",", "showing", "more", "pronounced", "effects", "than", "when", "the", "two", "antagonists", "were", "injected", "alone", "."], "h": {"id": "C0126174", "name": "C0126174#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334081", "name": "C1334081#ent", "pos": [9, 10]}}
{"token": ["To", "elucidate", "the", "significance", "of", "fibrinolytic", "enzymes", "ovulation", ",", "the", "changes", "in", "the", "levels", "of", "plasminogen", "activator", "C1367553#ent", "<e1>", "and", "plasmin", "activity", "examined", "using", "prepubertal", "rats", "and", "sows", "treated", "with", "C1868117#ent", "<e2>", "and", "hCG", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1868117", "name": "C1868117#ent", "pos": [30, 31]}}
{"token": ["C0960371#ent", "<e1>", ",", "in", "addition", "to", "PAR-2", ",", "can", "also", "activate", "C1705939#ent", "<e2>", "and", "PAR-4", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705939", "name": "C1705939#ent", "pos": [11, 12]}}
{"token": ["Two", "recently", "published", "papers", "C0752121#ent", "<e1>", "together", "with", "studies", "on", "C0752353#ent", "<e2>", "year", ",", "indicate", "that", "host", "protein", "context", "is", "the", "key", "arbiter", "of", "polyglutamine", "disease", "toxicity", "."], "h": {"id": "C0752121", "name": "C0752121#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0752353", "name": "C0752353#ent", "pos": [10, 11]}}
{"token": ["The", "HLA-B27", "tissue", "antigen", "associated", "with", "reactive", "arthritis", "by", "different", "C0004623#ent", "<e1>", "its", "occurrence", "in", "C1692886#ent", "<e2>", "not", "been", "studied", "earlier", "."], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C1692886", "name": "C1692886#ent", "pos": [15, 16]}}
{"token": ["The", "protective", "effect", "C1705225#ent", "<e1>", "1.5", "ng", ")", "was", "completely", "abolished", "by", "C0021246#ent", "<e2>", "(", "5", "mg/kg", "IP", ")", "and", "atropine", "(", "2", "mg/kg", "SC", ")", "pretreatment", "."], "h": {"id": "C1705225", "name": "C1705225#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [12, 13]}}
{"token": ["C0762592#ent", "<e1>", "is", "a", "small", "molecule", "inhibitor", "VEGF", "receptors", "C1416655#ent", "<e2>", "and", "FLT3", "and", "therefore", "provides", "a", "novel", "opportunity", "to", "target", "both", "angiogenesis", "and", "proliferation", "in", "AML", "."], "h": {"id": "C0762592", "name": "C0762592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416655", "name": "C1416655#ent", "pos": [9, 10]}}
{"token": ["The", "increase", "in", "C1417245#ent", "<e1>", "expression", "we", "observed", "in", "C2931257#ent", "<e2>", "brains", "raises", "the", "possibility", "that", "the", "enzyme", "contributes", "to", "the", "oxidative", "stress", "in", "the", "pathogenesis", "of", "the", "neurodegenerative", "disorder"], "h": {"id": "C1417245", "name": "C1417245#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2931257", "name": "C2931257#ent", "pos": [9, 10]}}
{"token": ["We", "have", "determined", "the", "role", "played", "by", "the", "phosphoenolpyruvate", ":", "C0031646#ent", "<e1>", "PTS", ")", "in", "C0524928#ent", "<e2>", "catabolite", "repression", "(", "CCR", ")", "of", "xylose", "utilization", "in", "Bacillus", "megaterium"], "h": {"id": "C0031646", "name": "C0031646#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [15, 16]}}
{"token": ["Experiments", "with", "different", "pts", "mutants", "showed", "that", "the", "phosphoenolpyruvate", ":", "C0031646#ent", "<e1>", "not", "involved", "in", "C0524928#ent", "<e2>", "catabolite", "repression", "of", "beta-glucanase", "synthesis"], "h": {"id": "C0031646", "name": "C0031646#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [15, 16]}}
{"token": ["In", "sterol-depleted", "cells", ",", "SCAP", "escorts", "SREBPs", "from", "ER", "to", "C1423498#ent", "<e1>", ",", "where", "SREBPs", "are", "cleaved", "by", "C0759784#ent", "<e2>", "S1P", ")", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0759784", "name": "C0759784#ent", "pos": [18, 19]}}
{"token": ["Yet", "splenocytes", "from", "hyperglycemic", "mutant", "donors", "failed", "to", "C0011854#ent", "<e1>", "NOD.Rag1(-/-", ")", "recipients", "over", "a", "13-week", "period", ",", "whereas", "C2987364#ent", "<e2>", "donor", "cells", "so", "."], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [19, 20]}}
{"token": ["Basal", "C1337111#ent", "<e1>", "secretion", "was", "elevated", "by", "the", "C3850099#ent", "<e2>", "sulpiride", ",", "but", "acetylcholine", "was", "without", "effect", "in", "the", "10-day-old", "and", "in", "the", "adult", "neurointermediate", "lobe", "even", "after", "dopamine", "receptor", "blockade", "."], "h": {"id": "C1337111", "name": "C1337111#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3850099", "name": "C3850099#ent", "pos": [8, 9]}}
{"token": ["RSTS", "is", "caused", "by", "chromosomal", "rearrangements", "point", "mutations", "in", "one", "copy", "of", "the", "C1530423#ent", "<e1>", "CREBBP", "or", "C1337090#ent", "<e2>", ")", "in", "16p13.3", "."], "h": {"id": "C1530423", "name": "C1530423#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1337090", "name": "C1337090#ent", "pos": [17, 18]}}
{"token": ["C3640123#ent", "<e1>", "usually", "requires", "the", "use", "of", "C0001645#ent", "<e2>", "however", ",", "and", "these", "may", "also", "carry", "the", "risk", "of", "cardiac", "ischemia", "especially", "in", "patients", "with", "ischemic", "diseases"], "h": {"id": "C3640123", "name": "C3640123#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [7, 8]}}
{"token": ["The", "results", "of", "this", "study", "may", "suggest", "that", "women", "on", "antiepileptic", "treatment", "with", "C0031507#ent", "<e1>", "should", "be", "given", "an", "oral", "contraceptive", "a", "comparatively", "high", "dose", "the", "C0038317#ent", "<e2>", "to", "provide", "contraceptive", "efficacy", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [26, 27]}}
{"token": ["Eight", "cases", "had", "C0038220#ent", "<e1>", "and", "seven", "of", "them", "had", "C0085543#ent", "<e2>"], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [10, 11]}}
{"token": ["Bathing", "the", "CC", "in", "10(-7", ")", "M", "octopamine", "resulted", "in", "the", "release", "of", "C0020473#ent", "<e1>", "and", "this", "release", "was", "blocked", "by", "C0031441#ent", "<e2>", "."], "h": {"id": "C0020473", "name": "C0020473#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031441", "name": "C0031441#ent", "pos": [21, 22]}}
{"token": ["In", "a", "modified", "case-control", "study", "obstructive", "pulmonary", "disease", "COPD", ")", ",", "C0001883#ent", "<e1>", "been", "found", "to", "be", "associated", "with", "age", ",", "sex", ",", "C0033607#ent", "<e2>", "socioeconomic", "status", "SES", ")", "and", "smoking", "."], "h": {"id": "C0001883", "name": "C0001883#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033607", "name": "C0033607#ent", "pos": [23, 24]}}
{"token": ["The", "trial", "evaluated", "the", "effectiveness", "of", "the", "investigational", "antihistaminic", "and", "antiallergic", "compound", "C0052762#ent", "<e1>", "Eye", "Drops", "AZE", ")", "in", "the", "treatment", "of", "C0009766#ent", "<e2>", "an", "allergen", "challenge", "model"], "h": {"id": "C0052762", "name": "C0052762#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0009766", "name": "C0009766#ent", "pos": [22, 23]}}
{"token": ["C0031727#ent", "<e1>", "henceforth", "be", "referred", "to", "as", "C1739697#ent", "<e2>"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1739697", "name": "C1739697#ent", "pos": [7, 8]}}
{"token": ["In", "vitro", "receptor", "binding", "studies", "that", "phosphorylated", "C0209245#ent", "<e1>", "did", "not", "bind", "the", "C1335265#ent", "<e2>"], "h": {"id": "C0209245", "name": "C0209245#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335265", "name": "C1335265#ent", "pos": [13, 14]}}
{"token": ["The", "study", "population", "children", "with", "C3714552#ent", "<e1>", "spasticity", "who", "underwent", "C1420371#ent", "<e2>", "and", "were", "evaluated", "by", "a", "multidisciplinary", "team", "preoperatively", ",", "at", "6", "months", "and", "1", "year", "postoperatively", "."], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420371", "name": "C1420371#ent", "pos": [10, 11]}}
{"token": ["C1451099#ent", "<e1>", "is", "a", "potent", "selective", "inhibitor", "of", "C0243045#ent", "<e2>", "7", ",", "and", "9", ",", "and", "inhibits", "both", "transcription", "and", "cell", "cycle"], "h": {"id": "C1451099", "name": "C1451099#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_affects_gene_product", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [8, 9]}}
{"token": ["The", "relative", "contributions", "of", "cellular", "and", "humoral", "immunity", "cartilage", "destruction", "C0263680#ent", "<e1>", "been", "investigated", "in", "a", "model", "of", "C0039103#ent", "<e2>", "the", "rabbit", "."], "h": {"id": "C0263680", "name": "C0263680#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0039103", "name": "C0039103#ent", "pos": [18, 19]}}
{"token": ["C0030071#ent", "<e1>", "is", "often", "used", "as", "a", "decongestant", "in", "C0035455#ent", "<e2>", "patients", "who", "are", "suffering", "from", "nasal", "obstruction"], "h": {"id": "C0030071", "name": "C0030071#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0035455", "name": "C0035455#ent", "pos": [9, 10]}}
{"token": ["Skin", "manifestations", "C0009186#ent", "<e1>", "can", "either", "be", "C0015230#ent", "<e2>", "such", "as", "erythema", "multiforme", "erythema", "nodosum", "associated", "with", "primary", "pulmonary", "infection", "or", "they", "can", "be", "the", "result", "of", "extrapulmonary", "dissemination", "of", "the", "infection", "to", "the", "skin", "."], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [7, 8]}}
{"token": ["To", "this", "extent", ",", "then", ",", "MS", "would", "be", "comparable", "to", "other", "chronic-inflammatory", "C0007682#ent", "<e1>", "as", "AIDS", ",", "C0752235#ent", "<e2>", ",", "syphilis", "and", "certain", "forms", "of", "viral", "encephalitis"], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [18, 19]}}
{"token": ["2D", "NMR", "data", "showed", "that", "the", "C0032594#ent", "<e1>", "of", "a", "tetrasaccharide", "repeating", "unit", "containing", "C1135697#ent", "<e2>", "as", "well", "as", "O-acetylated", "or", "O-methylated", "6-deoxytalopyranose", "residues", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1135697", "name": "C1135697#ent", "pos": [14, 15]}}
{"token": ["We", "report", "that", "human", "glioma", "cells", "the", "C3642258#ent", "<e1>", "MICA", ",", "MICB", ",", "and", "members", "of", "the", "C1423032#ent", "<e2>", "."], "h": {"id": "C3642258", "name": "C3642258#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1423032", "name": "C1423032#ent", "pos": [17, 18]}}
{"token": ["Specific", "and", "tertiary", "granules", "C3811805#ent", "<e1>", ",", "VAMP-2", ",", "and", "C4284285#ent", "<e2>", ",", "whereas", "the", "azurophilic", "granule", "membranes", "were", "enriched", "in", "C3811805#ent", "<e1>", "and", "VAMP-7", "."], "h": {"id": "C4284285", "name": "C4284285#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3811805", "name": "C3811805#ent", "pos": [4, 5]}}
{"token": ["Methyl", "CCNU", "first", "dissolved", "in", "absolute", "C0001962#ent", "<e1>", "and", "slowly", "added", "to", "a", "fat", "emulsion", "C0733854#ent", "<e2>", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0733854", "name": "C0733854#ent", "pos": [15, 16]}}
{"token": ["Patients", "with", "the", "X-linked", "form", "C3811755#ent", "<e1>", "have", "mutations", "in", "the", "C0079429#ent", "<e2>", "for", "the", "beta-subunit", "of", "cytochrome", "b558", "gp91-phox", ")", "."], "h": {"id": "C3811755", "name": "C3811755#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["C0086444#ent", "<e1>", "was", "developed", "as", "a", "specific", "cardioprotectant", "\"", "C3536843#ent", "<e2>", "\"", "which", "can", "prevent", "anthracycline", "cardiotoxicity", "without", "inhibiting", "its", "antitumor", "effect"], "h": {"id": "C0086444", "name": "C0086444#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536843", "name": "C3536843#ent", "pos": [9, 10]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "coding", "sequence", "polymorphisms", "in", "the", "C1704463#ent", "<e1>", "to", "the", "C0012634#ent", "<e2>", "patients", "with", "cystic", "fibrosis"], "h": {"id": "C1704463", "name": "C1704463#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["We", "have", "investigated", "C0017355#ent", "<e1>", "class", "II", "antigens", "patients", "with", "C0524909#ent", "<e2>", "to", "a", "healthy", "control", "population"], "h": {"id": "C0017355", "name": "C0017355#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524909", "name": "C0524909#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "this", "work", "was", "to", "investigate", "the", "distribution", "of", "C0049289#ent", "<e1>", "in", "the", "skin", "after", "oral", "administration", "the", "C1254351#ent", "<e2>", "and", "to", "examine", "the", "correlation", "between", "skin", "and", "plasma", "concentrations"], "h": {"id": "C0049289", "name": "C0049289#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [20, 21]}}
{"token": ["DNA", "cleavage", "sites", "stimulated", "by", "two", "anthracycline", "analogues", ",", "dh-EPI", "and", "C1846006#ent", "<e1>", ",", "were", "investigated", "at", "the", "C3890742#ent", "<e2>", "cultured", "Drosophila", "Kc", "cells", "."], "h": {"id": "C1846006", "name": "C1846006#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3890742", "name": "C3890742#ent", "pos": [18, 19]}}
{"token": ["Older", "age", "female", "gender", ",", "recent", "congestive", "heart", "failure", "decreasing", "fractional", "shortening", "recent", "onset", "of", "AF", ",", "and", "C0010054#ent", "<e1>", "each", "univariately", "associated", "with", "levels", "of", "C1423108#ent", "<e2>", "(", "all", "p<0.05", ",", "two-sample", "t-test", ",", "simple", "linear", "regression", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1423108", "name": "C1423108#ent", "pos": [26, 27]}}
{"token": ["To", "test", "this", "hypothesis", ",", "we", "studied", "the", "effects", "of", "dietary", "protein", "restriction", "DNA", "synthesis", "c-myc", "and", "C0079060#ent", "<e1>", "mRNA", "responses", "to", "growth", "hormone", "the", "C0023899#ent", "<e2>", "of", "hypophysectomized", "rats", "."], "h": {"id": "C0079060", "name": "C0079060#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [25, 26]}}
{"token": ["There", "are", "few", "studies", "quantifying", "the", "effects", "of", "C0020591#ent", "<e1>", "on", "oxygenation", "during", "sleep", "in", "patients", "with", "stable", "hypoxemic", "C1647218#ent", "<e2>", "."], "h": {"id": "C0020591", "name": "C0020591#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [19, 20]}}
{"token": ["Whereas", "C0751039#ent", "<e1>", "also", "inhibited", "ADF/TRX", "expression", "in", "OKT3", "mAb-stimulated", "PBMC", ",", "C1416920#ent", "<e2>", "failed", "to", "affect", "it", "in", "spite", "of", "exhibiting", "growth", "inhibition"], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416920", "name": "C1416920#ent", "pos": [12, 13]}}
{"token": ["Trials", "in", "patients", "with", "C0003873#ent", "<e1>", "osteoarthritis", "showed", "C0038792#ent", "<e2>", "to", "be", "an", "analgesic", "with", "anti-inflammatory", "properties", "at", "least", "as", "effective", "as", "aspirin", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [8, 9]}}
{"token": ["Complications", "of", "C0018190#ent", "<e1>", "such", "as", "C0013884#ent", "<e2>", ",", "stricture", "and", "pelvic", "abscess", "require", "surgery", "."], "h": {"id": "C0018190", "name": "C0018190#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013884", "name": "C0013884#ent", "pos": [6, 7]}}
{"token": ["These", "findings", "are", "concordant", "with", "the", "observation", "that", "both", "genes", "are", "expressed", "in", "C1171315#ent", "<e1>", "but", "only", "C0013570#ent", "<e2>", "29", "expression", "has", "been", "identified", "in", "latency", "."], "h": {"id": "C1171315", "name": "C1171315#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013570", "name": "C0013570#ent", "pos": [17, 18]}}
{"token": ["C0059037#ent", "<e1>", "Bart's", "disease", "an", "uncommon", "form", "of", "C0271979#ent", "<e2>", "from", "the", "co-inheritance", "of", "alpha-thalassaemia", "and", "haemoglobin", "E", "the", "same", "subject", "."], "h": {"id": "C0059037", "name": "C0059037#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0271979", "name": "C0271979#ent", "pos": [8, 9]}}
{"token": ["Five", "patterns", "have", "been", "defined", ":", "C0017668#ent", "<e1>", "not", "otherwise", "specified", ",", "C4054944#ent", "<e2>", "cellular", "variant", "tip", "variant", "and", "collapsing", "variant"], "h": {"id": "C0017668", "name": "C0017668#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C4054944", "name": "C4054944#ent", "pos": [12, 13]}}
{"token": ["Also", ",", "antibodies", "to", "uPAR", "and", "gC1qR", "each", "inhibited", "86", "%", "of", "C0022478#ent", "<e1>", ",", "2-chain", "urokinase", "plasminogen", ",", "whereas", "antibodies", "to", "C1332795#ent", "<e2>", "only", "inhibited", "24", "%", "of", "plasminogen", "activation"], "h": {"id": "C0022478", "name": "C0022478#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332795", "name": "C1332795#ent", "pos": [22, 23]}}
{"token": ["We", "also", "show", "that", "C1705458#ent", "<e1>", "was", "involved", "in", "activation", "of", "C0525037#ent", "<e2>", "expression", "in", "293", "T", "cells"], "h": {"id": "C1705458", "name": "C1705458#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0525037", "name": "C0525037#ent", "pos": [11, 12]}}
{"token": ["Activation", "of", "p42", "and", "C4082284#ent", "<e1>", "MAPKs", "increases", "C1366500#ent", "<e2>", "PR", ")", "transcriptional", "activity", "the", "presence", "of", "progestins", ",", "and", "triggers", "their", "rapid", "down-regulation", "by", "the", "ubiquitin-proteasome", "pathway"], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1366500", "name": "C1366500#ent", "pos": [8, 9]}}
{"token": ["We", "report", "a", "patient", "with", "muscle-specific", "tyrosine", "kinase", "MuSK", ")", "antibody-positive", "C0026896#ent", "<e1>", "experienced", "worsening", "of", "myasthenic", "weakness", "associated", "with", "alterations", "in", "estrogen", "and", "C2757070#ent", "<e2>", "levels", "during", "the", "administration", "of", "oral", "contraceptive", "therapy"], "h": {"id": "C0026896", "name": "C0026896#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2757070", "name": "C2757070#ent", "pos": [24, 25]}}
{"token": ["In", "addition", ",", "blocking", "C1416933#ent", "<e1>", "STAT5", "activation", "with", "a", "C4086530#ent", "<e2>", "AG-490", ")", "significantly", "reduced", "Foxp3", "expression", "in", "Treg", "."], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4086530", "name": "C4086530#ent", "pos": [10, 11]}}
{"token": ["Patients", "with", "C0684275#ent", "<e1>", "(", "1", "x", "hemophilia", "A", "1", "x", "C0015523#ent", "<e2>", "gave", "normal", "PFA-100", "CT", ",", "while", "those", "with", "clinical", "thrombocytopaenia", "N", "=", "3", ")", "gave", "prolonged", "PFA-100", "CT", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0015523", "name": "C0015523#ent", "pos": [11, 12]}}
{"token": ["The", "C0299505#ent", "<e1>", "modulates", "the", "ubiquitination", "and", "subsequent", "destruction", "of", "hypoxia-inducible", "factor", "1", "subunit", "alpha", "C0906566#ent", "<e2>", ")", "."], "h": {"id": "C0299505", "name": "C0299505#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0906566", "name": "C0906566#ent", "pos": [15, 16]}}
{"token": ["Localized", "C0023283#ent", "<e1>", "LCL", ")", "is", "a", "common", "cause", "of", "C0018567#ent", "<e2>", "in", "travelers", "returning", "from", "the", "tropics", "."], "h": {"id": "C0023283", "name": "C0023283#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0018567", "name": "C0018567#ent", "pos": [10, 11]}}
{"token": ["Determination", "of", "specific", "C1335837#ent", "<e1>", "revealed", "that", "this", "C0025598#ent", "<e2>", "effect", "is", "not", "associated", "with", "increase", "in", "glucose", "transporter", "gene", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C1335837", "name": "C1335837#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [8, 9]}}
{"token": ["We", "review", "the", "different", "ways", "that", "TMS", "has", "been", "used", "to", "investigate", "pathophysiological", "mechanisms", "and", "effects", "of", "C0003299#ent", "<e1>", "patients", "with", "epilepsy", "and", "C0751785#ent", "<e2>"], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0751785", "name": "C0751785#ent", "pos": [23, 24]}}
{"token": ["For", "migraine", ",", "C0016295#ent", "<e1>", "was", "compared", "to", "propranolol", "in", "686", "patients", ";", "for", "vertigo", ",", "C0016295#ent", "<e1>", "was", "compared", "to", "C0005301#ent", "<e1>", "in", "198", "patients", "."], "h": {"id": "C0016295", "name": "C0016295#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0005301", "name": "C0005301#ent", "pos": [21, 22]}}
{"token": ["Using", "a", "model", "of", "integrin-triggered", "random", "migration", "of", "T", "cells", "we", "show", "that", "stimulation", "of", "C1334144#ent", "<e1>", "to", "the", "activation", "of", "Rap1", "and", "C1419269#ent", "<e2>", "small", "GTPases", "."], "h": {"id": "C1334144", "name": "C1334144#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1419269", "name": "C1419269#ent", "pos": [23, 24]}}
{"token": ["Six", "cats", "with", "chronic", "progressive", "neurologic", "signs", "ataxia", ",", "C0221166#ent", "<e1>", ",", "tremors", ",", "pupillary", "abnormalities", "seizures", "had", "C0864670#ent", "<e2>", "of", "probable", "viral", "origin"], "h": {"id": "C0221166", "name": "C0221166#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0864670", "name": "C0864670#ent", "pos": [18, 19]}}
{"token": ["Recently", ",", "farnesol", "was", "shown", "to", "be", "C0025517#ent", "<e1>", "by", "cytochromes", "P450", "rabbit", ";", "however", ",", "neither", "C0015637#ent", "<e2>", "glucuronidation", "in", "humans", "have", "been", "reported", "to", "date", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0015637", "name": "C0015637#ent", "pos": [17, 18]}}
{"token": ["Overexpression", "of", "Xenopus", "C1420069#ent", "<e1>", "causes", "ectopic", "neural", "induction", "inhibition", "of", "C0377148#ent", "<e2>", "BMP", ")", "signaling", "and", "inhibition", "of", "Xbra", "expression", "."], "h": {"id": "C1420069", "name": "C1420069#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0377148", "name": "C0377148#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "the", "data", "reported", "here", "demonstrate", "that", "miR-221", "and", "C1537860#ent", "<e1>", "are", "endogenous", "regulators", "of", "C1332737#ent", "<e2>", "expression", ",", "and", "thereby", ",", "the", "cell", "cycle"], "h": {"id": "C1537860", "name": "C1537860#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1332737", "name": "C1332737#ent", "pos": [16, 17]}}
{"token": ["Treatment", "with", "C0034235#ent", "<e1>", "in", "this", "herd", "also", "indicated", "cross-resistance", "to", "this", "C0013227#ent", "<e2>", "."], "h": {"id": "C0034235", "name": "C0034235#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "PDBu", ",", "IDB", ",", "or", "C0006945#ent", "<e1>", "resulted", "in", "a", "time-", "and", "concentration-dependent", "translocation", "of", "C1538842#ent", "<e2>", "from", "the", "cytoplasm", "to", "filamentous", "structures", "smooth", "muscle", "cells"], "h": {"id": "C0006945", "name": "C0006945#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538842", "name": "C1538842#ent", "pos": [17, 18]}}
{"token": ["In", "C0011860#ent", "<e1>", "observation", "of", "a", "decreased", "release", "of", "C1522405#ent", "<e2>", "(", "IL-2", ")", "and", "soluble", "IL-2", "receptors", "means", "of", "stimulated", "lymphocytes", "in", "vitro", "that", "a", "primary", "immunoregulatory", "defect", "be", "involved", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "a", "possible", "association", "with", "C1418625#ent", "<e1>", "PAF-AH", ")", "gene", "mutation", "the", "risk", "of", "abdominal", "aortic", "aneurysm", "C1364818#ent", "<e2>", ")", "."], "h": {"id": "C1418625", "name": "C1418625#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [18, 19]}}
{"token": ["In", "addition", ",", "C0024115#ent", "<e1>", "often", "a", "component", "of", "collagen", "diseases", "C0028797#ent", "<e2>", "idiopathic", "pulmonary", "fibrosis"], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028797", "name": "C0028797#ent", "pos": [11, 12]}}
{"token": ["C0021246#ent", "<e1>", "did", "not", "affect", "the", "hemodynamic", "responses", "to", "C0078107#ent", "<e2>", "administration", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0078107", "name": "C0078107#ent", "pos": [9, 10]}}
{"token": ["To", "identify", "these", "transporters", ",", "we", "examined", "mGluR1", "EPSCs", "in", "mice", "lacking", "GLAST", "(", "for", "glutamate-aspartate", "transporter", "C1420121#ent", "<e1>", ")", "or", "EAAC1", "(", "for", "C0243046#ent", "<e2>", "EAAT3", ")", "."], "h": {"id": "C1420121", "name": "C1420121#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0243046", "name": "C0243046#ent", "pos": [24, 25]}}
{"token": ["Diacylglycerol", "(", "DAG", ")", ",", "a", "physiological", "C0304402#ent", "<e1>", "of", "PKC", ",", "also", "increased", "the", "expression", "of", "C1704939#ent", "<e2>", "mRNA", "and", "P-glycoprotein", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [17, 18]}}
{"token": ["A", "28-year-old", "man", "was", "transferred", "to", "our", "hospital", "because", "of", "C0235704#ent", "<e1>", ",", "nausea", "and", "C0013404#ent", "<e2>", "."], "h": {"id": "C0235704", "name": "C0235704#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [15, 16]}}
{"token": ["Both", "EDN", "and", "the", "related", "granule", "protein", "eosinophil", "cationic", "protein", "have", "ribonucleolytic", "activity", "sequence", "similarities", "among", "EDN", ",", "eosinophil", "cationic", "protein", "C0035542#ent", "<e1>", "from", "liver", ",", "urine", ",", "and", "pancreas", ",", "and", "C0051844#ent", "<e2>", "define", "a", "ribonuclease", "multigene", "family"], "h": {"id": "C0035542", "name": "C0035542#ent", "pos": [21, 22]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0051844", "name": "C0051844#ent", "pos": [32, 33]}}
{"token": ["Antisense", "src", "RNA", "expression", "in", "K562", "cells", "inhibited", "the", "erythropoietin-induced", "activation", "of", "C0044602#ent", "<e1>", "and", "its", "association", "with", "C1333342#ent", "<e2>"], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333342", "name": "C1333342#ent", "pos": [18, 19]}}
{"token": ["The", "methylation", "status", "C0525037#ent", "<e1>", ",", "p14ARF", ",", "VHL", ",", "and", "C1882525#ent", "<e2>", "was", "analysed", "together", "with", "clinicopathological", "factors", "."], "h": {"id": "C0525037", "name": "C0525037#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1882525", "name": "C1882525#ent", "pos": [11, 12]}}
{"token": ["The", "inhibitory", "activity", "of", "C0004320#ent", "<e1>", "on", "adjuvant", "arthritis", "weaker", "than", "that", "of", "C0021246#ent", "<e2>", "."], "h": {"id": "C0004320", "name": "C0004320#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [13, 14]}}
{"token": ["Using", "small", "interfering", "RNA", "to", "suppress", "endogenous", "ubiquitin", "expression", "and", "C1443643#ent", "<e1>", "repress", "ubiquitin-mediated", "protein", "degradation", "we", "showed", "that", "HMGA2", "confers", "C0023524#ent", "<e2>", "down-regulation", "through", "ubiquitin-proteasome-dependent", "protein", "degradation", "."], "h": {"id": "C1443643", "name": "C1443643#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [21, 22]}}
{"token": ["A", "simple", ",", "rapid", ",", "and", "precise", "reversed-phase", "liquid", "chromatographic", "method", "developed", "for", "simultaneous", "determination", "of", "paracetamol", ",", "C0050403#ent", "<e1>", ",", "and", "chlorzoxazone", "in", "their", "ternary", "mixtures", "commercial", "C1720946#ent", "<e2>"], "h": {"id": "C0050403", "name": "C0050403#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1720946", "name": "C1720946#ent", "pos": [28, 29]}}
{"token": ["A", "recent", "study", "of", "thrombohemorrhagic", "phenomena", "infusion", "with", "C1366464#ent", "<e1>", "concentrates", "in", "patients", "with", "congenital", "Factor", "IX", "deficiency", "C0008533#ent", "<e2>", "or", "liver", "disease", "revealed", "an", "incidence", "of", "twenty", "episodes", "in", "188", "cases", "(", "11", "%", ")", "."], "h": {"id": "C1366464", "name": "C1366464#ent", "pos": [8, 9]}, "relation": "gene_associated_with_disease", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [18, 19]}}
{"token": ["Because", "tubular", "damage", "monocyte", "infiltration", "are", "two", "hallmarks", "of", "C0041349#ent", "<e1>", "the", "effect", "of", "C1414504#ent", "<e2>", "on", "DNA", "synthesis", "monocyte", "chemotactic", "peptide-1", "MCP-1", ")", "gene", "and", "protein", "expression", "evaluated", "in", "cultured", "hPTC", "."], "h": {"id": "C0041349", "name": "C0041349#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "suggest", "that", "inflammation", "and", "C0042769#ent", "<e1>", "the", "lower", "airway", "are", "present", "during", "C0009443#ent", "<e2>", "and", "that", "inflammation", "is", "also", "present", "during", "the", "convalescent", "period", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0009443", "name": "C0009443#ent", "pos": [14, 15]}}
{"token": ["The", "dorsal", "expression", "of", "C1421581#ent", "<e1>", "was", "regulated", "by", "Sonic", "hedgehog", "C1412805#ent", "<e2>", ",", "and", "BMP7", ",", "as", "revealed", "by", "their", "overexpressions", "in", "the", "spinal", "cord"], "h": {"id": "C1421581", "name": "C1421581#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412805", "name": "C1412805#ent", "pos": [11, 12]}}
{"token": ["An", "open", "reading", "frame", "184", "C3539946#ent", "<e1>", "encoding", "the", "C1414527#ent", "<e2>", "precursor", ",", "which", "is", "processed", "to", "the", "mature", "protein", ",", "was", "found", ";", "it", "consisted", "of", "156", "C3539946#ent", "<e1>", "a", "calculated", "molecular", "weight", "16,000", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414527", "name": "C1414527#ent", "pos": [9, 10]}}
{"token": ["HPLC", "analysis", "of", "products", "revealed", "that", "the", "intermediate", "malonyl-AMP", "is", "not", "accumulated", "during", "C1417081#ent", "<e1>", "catalysis", "and", "that", "none", "of", "the", "mutant", "C3541394#ent", "<e2>", "accumulated", "it", "either", "."], "h": {"id": "C1417081", "name": "C1417081#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [22, 23]}}
{"token": ["Evidence", "has", "shown", "that", "aspirin", ",", "C0000598#ent", "<e1>", "and", "clopidogrel", "share", "C0242912#ent", "<e2>", "explained", "by", "the", "platelet", "paradigm", "and", "that", "are", "reminiscent", "of", "a", "preconditioning", "effect", "."], "h": {"id": "C0000598", "name": "C0000598#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [11, 12]}}
{"token": ["The", "C0609199#ent", "<e1>", "TruD", ",", "that", "modifies", "C1822917#ent", "<e2>", "in", "tRNA", ",", "belongs", "to", "a", "recently", "identified", "and", "large", "family", "of", "pseudouridine", "synthases", "in", "all", "kingdoms", "of", "."], "h": {"id": "C0609199", "name": "C0609199#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1822917", "name": "C1822917#ent", "pos": [7, 8]}}
{"token": ["Both", "the", "human", "C1420214#ent", "<e1>", "5-HTT", ")", "and", "human", "dopamine", "transporter", "C1416882#ent", "<e2>", ")", "genes", "are", "good", "candidates", "for", "etiological", "involvement", "in", "various", "psychiatric", "conditions"], "h": {"id": "C1420214", "name": "C1420214#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416882", "name": "C1416882#ent", "pos": [11, 12]}}
{"token": ["Compounds", "4a", "b", "and", "5a-c", "antagonize", "seizures", "induced", "by", "AMPA", "and", "kainate", "(", "KA", ")", "and", "their", "C0003286#ent", "<e1>", "reversed", "by", "pretreatment", "with", "C0051917#ent", "<e2>", "."], "h": {"id": "C0003286", "name": "C0003286#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0051917", "name": "C0051917#ent", "pos": [23, 24]}}
{"token": ["Here", ",", "we", "report", "that", "C1705730#ent", "<e1>", "(", "FRS2", ")", ",", "an", "adaptor", "protein", "links", "C1333542#ent", "<e2>", "multiple", "signaling", "pathways", "mediates", "crucial", "aspects", "of", "FGF-dependent", "OFT", "development", "in", "mouse", "."], "h": {"id": "C1705730", "name": "C1705730#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333542", "name": "C1333542#ent", "pos": [15, 16]}}
{"token": ["Both", "SETA", "and", "AIP1", "interacted", "with", "C1366894#ent", "<e1>", "FAK", ")", "and", "proline", "rich", "tyrosine", "kinase", "2", "PYK-2", ")", ",", "and", "C1707078#ent", "<e2>", "interacted", "with", "PYK-2", "."], "h": {"id": "C1366894", "name": "C1366894#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1707078", "name": "C1707078#ent", "pos": [20, 21]}}
{"token": ["The", "activity", "of", "alanine", "aminotransferase", "C1418544#ent", "<e1>", ")", "increased", "only", "in", "C0036572#ent", "<e2>"], "h": {"id": "C1418544", "name": "C1418544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [11, 12]}}
{"token": ["Patients", "without", "C0520575#ent", "<e1>", "changes", "and", "with", "normal", "serum", "creatinine", "showed", "normal", "excretion", "of", "C0443534#ent", "<e2>", "."], "h": {"id": "C0520575", "name": "C0520575#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0443534", "name": "C0443534#ent", "pos": [14, 15]}}
{"token": ["We", "show", "here", "in", "primary", "cultures", "hepatocytes", "that", "the", "adenovirus-mediated", "transduction", "of", "a", "dominant", "negative", "form", "of", "C1420398#ent", "<e1>", "inhibits", "the", "insulin", "effect", "endogenous", "C1415014#ent", "<e2>", "expression", "."], "h": {"id": "C1420398", "name": "C1420398#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415014", "name": "C1415014#ent", "pos": [24, 25]}}
{"token": ["Conversely", ",", "in", "the", "absence", "of", "insulin", ",", "the", "adenovirus-mediated", "transduction", "of", "a", "dominant", "positive", "form", "of", "C1420398#ent", "<e1>", "overcomes", "the", "insulin", "dependency", "of", "C1415014#ent", "<e2>", "expression", "."], "h": {"id": "C1420398", "name": "C1420398#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415014", "name": "C1415014#ent", "pos": [24, 25]}}
{"token": ["Fingernail", "growth", "studied", "in", "28", "patients", "who", "were", "receiving", "systemic", "treatment", "the", "C0035339#ent", "<e1>", "Ro", "10", "9359", "known", "as", "C0729231#ent", "<e2>", "(", "etretinate", ";", "AR", ")", "."], "h": {"id": "C0035339", "name": "C0035339#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0729231", "name": "C0729231#ent", "pos": [19, 20]}}
{"token": ["Galactosyltransferase", "(", "C0040015#ent", "<e1>", ")", "belongs", "to", "the", "C0085249#ent", "<e2>", "."], "h": {"id": "C0040015", "name": "C0040015#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [8, 9]}}
{"token": ["We", "found", "that", "levels", "of", "sIL-6R", "in", "serum", ",", "BALF", ",", "and", "C1420388#ent", "<e1>", "from", "patients", "with", "C3273618#ent", "<e2>", "or", "sarcoidosis", "were", "significantly", "higher", "those", "from", "normal", "subjects"], "h": {"id": "C1420388", "name": "C1420388#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3273618", "name": "C3273618#ent", "pos": [17, 18]}}
{"token": ["Sequence", "analysis", "this", "fragment", "predicted", "five", "C1412821#ent", "<e1>", "encoding", "xyloglucan", "fucosyltransferases", "dnak-type", "molecular", "chaperone", "BiP", "a", "putative", "C2717969#ent", "<e2>", "and", "a", "hypothetical", "protein", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2717969", "name": "C2717969#ent", "pos": [17, 18]}}
{"token": ["Previous", "work", "using", "viral", "polypeptide", "substrates", "synthesized", "by", "in", "vitro", "transcription", "and", "translation", "from", "the", "C0178827#ent", "<e1>", "both", "cis", "and", "trans", "cleavage", "activities", "for", "C0298455#ent", "<e2>", "."], "h": {"id": "C0178827", "name": "C0178827#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0298455", "name": "C0298455#ent", "pos": [24, 25]}}
{"token": ["Thoracentesis", "yielded", "3", "L", "of", "C0008733#ent", "<e1>", "confirmed", "by", "the", "C0242339#ent", "<e2>", "0.14", ")", "."], "h": {"id": "C0008733", "name": "C0008733#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242339", "name": "C0242339#ent", "pos": [10, 11]}}
{"token": ["These", "data", "indicate", "that", "at", "least", "one", "form", "of", "PI", ",", "PIP", ",", "and", "C3888278#ent", "<e1>", "associates", "with", "actin", "filaments", "actin", "binding", "proteins", "that", "cytoskeletal-associated", "PI", "C0031727#ent", "<e2>", "can", "change", "in", "response", "to", "external", "stimulation", "."], "h": {"id": "C3888278", "name": "C3888278#ent", "pos": [14, 15]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [26, 27]}}
{"token": ["One", "of", "the", "transcribed", "sequences", "isolated", "from", "this", "region", "corresponds", "to", "a", "novel", "C0079429#ent", "<e1>", "with", "homology", "to", "the", "C0537447#ent", "<e2>", "and", "harbours", "inactivating", "mutations", "in", "different", "patients", "with", "hereditary", "multiple", "exostoses"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0537447", "name": "C0537447#ent", "pos": [19, 20]}}
{"token": ["Iatrogenic", "hyperadrenocorticism", "(", "or", "C0010481#ent", "<e1>", "is", "an", "C0001621#ent", "<e2>", "may", "result", "from", "long-term", "administration", "of", "glucocorticoids", "for", "therapeutic", "purposes", "most", "often", "given", "to", "treat", "allergic", "or", "immune-mediated", "disorders"], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C0001621", "name": "C0001621#ent", "pos": [8, 9]}}
{"token": ["Therefore", ",", "C0362046#ent", "<e1>", "(", "lean", "and", "obese", ")", "and", "C0011860#ent", "<e2>", "subjects", "were", "studied", "on", "two", "occasions", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [10, 11]}}
{"token": ["Oxymetholone", ",", "a", "C0038317#ent", "<e1>", "of", "proven", "clinical", "value", "the", "treatment", "of", "C2981142#ent", "<e2>", "was", "without", "effect", "on", "endogenous", "or", "erythropoietin-mediated", "heme", "synthesis", "in", "fetal", "mouse", "liver", "cell", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2981142", "name": "C2981142#ent", "pos": [12, 13]}}
{"token": ["Empiric", "treatment", "C0277528#ent", "<e1>", "antibiotics", "and", "C0282221#ent", "<e2>", "is", "effective", "and", "often", "limits", "symptoms", "to", "one", "day", "."], "h": {"id": "C0277528", "name": "C0277528#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0282221", "name": "C0282221#ent", "pos": [6, 7]}}
{"token": ["C1142738#ent", "<e1>", "is", "a", "semi-synthetic", "echinocandin", "C0003308#ent", "<e2>", "for", "treatment", "of", "candidemia", "and", "invasive", "candidiasis"], "h": {"id": "C1142738", "name": "C1142738#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [6, 7]}}
{"token": ["We", "describe", "two", "patients", "with", "C0040517#ent", "<e1>", "whom", "severe", "motor", "tics", "the", "neck", "were", "complicated", "by", "C0149645#ent", "<e2>"], "h": {"id": "C0040517", "name": "C0040517#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149645", "name": "C0149645#ent", "pos": [16, 17]}}
{"token": ["For", "example", ",", "the", "mechanisms", "that", "C1539696#ent", "<e1>", "production", "with", "C3814378#ent", "<e2>", "oocytes", "remain", "to", "be", "determined", "."], "h": {"id": "C1539696", "name": "C1539696#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3814378", "name": "C3814378#ent", "pos": [10, 11]}}
{"token": ["Thus", ",", "C0666248#ent", "<e1>", "mediates", "the", "action", "of", "C1414928#ent", "<e2>", "and", "GADD45gamma", "on", "p38", "activation", "and", "IFNgamma", "production", "."], "h": {"id": "C0666248", "name": "C0666248#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414928", "name": "C1414928#ent", "pos": [8, 9]}}
{"token": ["Inhibition", "of", "monoamine", "oxidases", "MAOs", ")", "by", "C0030557#ent", "<e1>", ",", "but", "not", "of", "C1135159#ent", "<e2>", "(", "COMT", ")", "by", "tolcapone", ",", "slowed", "down", "DA", "elimination", "in", "knockout", "mice"], "h": {"id": "C0030557", "name": "C0030557#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1135159", "name": "C1135159#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "the", "enhanced", "production", "of", "C1332817#ent", "<e1>", "was", "suppressed", "by", "the", "C0919336#ent", "<e2>", "inhibitor", "."], "h": {"id": "C1332817", "name": "C1332817#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [12, 13]}}
{"token": ["This", "article", "discusses", "the", "pharmacology", "of", "dextroamphetamine", ",", "methylphenidate", ",", "C0030800#ent", "<e1>", "(", "and", "other", "psychostimulants", "such", "as", "caffeine", "and", "C0014479#ent", "<e2>", ")", ",", "their", "use", "in", "general", "medicine", "cancer", "care", "side", "effects", "and", "abuse", "potential"], "h": {"id": "C0030800", "name": "C0030800#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014479", "name": "C0014479#ent", "pos": [20, 21]}}
{"token": ["Systemic", "vascular", "alterations", "caused", "by", "deletion", "of", "the", "elastin", "gene", "occur", "early", "in", "individuals", "with", "C0175702#ent", "<e1>", "leading", "to", "the", "clinical", "manifestation", "C0020538#ent", "<e2>", "refractory", "to", "drug", "treatment"], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [15, 16]}, "relation": "has_manifestation", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [22, 23]}}
{"token": ["Treating", "C1416437#ent", "<e1>", "mutants", "with", "the", "C3537120#ent", "<e2>", "trichostatin", "A", "suppressed", "the", "mitotic", "delay", "restored", "global", "histone", "H4", "acetylation", "arguing", "that", "reduced", "H4", "acetylation", "underlie", "the", "cell", "cycle", "delay"], "h": {"id": "C1416437", "name": "C1416437#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3537120", "name": "C3537120#ent", "pos": [6, 7]}}
{"token": ["Overexpression", "of", "C1333897#ent", "<e1>", "increases", "C1413931#ent", "<e2>", "mRNA", "and", "protein", "level", "whereas", "down-regulation", "of", "C1333897#ent", "<e1>", "reduced", "the", "level", "of", "C1413931#ent", "<e2>", "."], "h": {"id": "C1333897", "name": "C1333897#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413931", "name": "C1413931#ent", "pos": [5, 6]}}
{"token": ["This", "PCD", "pathway", "is", "triggered", "through", "the", "Fas", "receptor", "involves", "the", "apoptosis", "signal-regulating", "kinase", "1", "C1417014#ent", "<e1>", ")", ",", "the", "p38", "MAP", "kinase", "and", "the", "neuronal", "form", "of", "C0132555#ent", "<e2>", "nNOS", ")", "."], "h": {"id": "C1417014", "name": "C1417014#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0132555", "name": "C0132555#ent", "pos": [28, 29]}}
{"token": ["Acroangiodermatitis", "is", "a", "special", "form", "of", "the", "'", "angiodermite", "'", "of", "C0024286#ent", "<e1>", "and", "Chaix", "in", "patients", "presenting", "with", "C0042485#ent", "<e2>", "localized", "on", "the", "dorsal", "areas", "the", "feet", "and", "toes", "."], "h": {"id": "C0024286", "name": "C0024286#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0042485", "name": "C0042485#ent", "pos": [19, 20]}}
{"token": ["The", "mineralization", "C4283936#ent", "<e1>", "shortened", "in", "C3831153#ent", "<e2>", ",", "normal", "in", "anticonvulsant", "bone", "disease", "in", "primary", "hyperparathyroidism", "and", "markedly", "prolonged", "in", "hypothyroidism", "and", "following", "jejunoileal", "bypass"], "h": {"id": "C4283936", "name": "C4283936#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3831153", "name": "C3831153#ent", "pos": [6, 7]}}
{"token": ["The", "ectonucleotide", "pyrophosphatase/phosphodiesterase", "1", "C1414407#ent", "<e1>", ")", "is", "an", "inhibitor", "of", "the", "C1334133#ent", "<e2>"], "h": {"id": "C1414407", "name": "C1414407#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [12, 13]}}
{"token": ["Like", "greater", "C0027796#ent", "<e1>", "trochleitis", "may", "sustain", "or", "trigger", "the", "pain", "of", "C1960870#ent", "<e2>"], "h": {"id": "C0027796", "name": "C0027796#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1960870", "name": "C1960870#ent", "pos": [12, 13]}}
{"token": ["Best", "results", "were", "obtained", "with", "an", "C0052822#ent", "<e1>", ",", "acenaphthene", "or", "C0027375#ent", "<e2>", "the", "two", "basic", "nitrogen", "functions"], "h": {"id": "C0052822", "name": "C0052822#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0027375", "name": "C0027375#ent", "pos": [11, 12]}}
{"token": ["To", "elucidate", "the", "role", "of", "anti-endothelial", "cell", "antibodies", "(", "AECA", ")", "in", "C0947751#ent", "<e1>", "patients", "with", "C3495801#ent", "<e2>", "WG", ")", "."], "h": {"id": "C0947751", "name": "C0947751#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3495801", "name": "C3495801#ent", "pos": [16, 17]}}
{"token": ["In", "contrast", ",", "C1956089#ent", "<e1>", "were", "not", "seen", "when", "the", "leg", "was", "C2350558#ent", "<e2>", "in", "flexion", "immediately", "after", "transection", "of", "the", "ligament", ",", "and", "the", "articular", "surface", "intact", "."], "h": {"id": "C1956089", "name": "C1956089#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2350558", "name": "C2350558#ent", "pos": [12, 13]}}
{"token": ["Apoptosis", "was", "characterised", "by", ":", "change", "in", "mitochondrial", "potential", ",", "C0291573#ent", "<e1>", "down-regulation", "of", "mRNA", "and", "protein", "for", "survivin", ",", "C1337109#ent", "<e2>", ",", "IAP1", ",", "IAP2", "and", "Bcl-XL", ",", "inhibition", "by", "caspase-3", "inhibitor"], "h": {"id": "C0291573", "name": "C0291573#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1337109", "name": "C1337109#ent", "pos": [20, 21]}}
{"token": ["In", "this", "report", "we", "would", "like", "to", "stress", "that", "the", "presence", "of", "C0040963#ent", "<e1>", "TS", ")", "is", "an", "additional", "significant", "cause", "of", "silent", "C0026769#ent", "<e2>", "."], "h": {"id": "C0040963", "name": "C0040963#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [23, 24]}}
{"token": ["Cytochalasin", "D", "which", "disrupts", "C1334752#ent", "<e1>", "network", ",", "completely", "inhibited", "C0006945#ent", "<e2>", "stimulated", "tyrosine", "phosphorylation", "these", "proteins", "without", "having", "significant", "effects", "in", "carbachol-stimulated", "amylase", "secretion", "."], "h": {"id": "C1334752", "name": "C1334752#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [10, 11]}}
{"token": ["This", "study", "tested", "the", "hypothesis", "that", "phencyclidine", "(", "C1418873#ent", "<e1>", ")", "is", "an", "indirect", "dopamine", "(", "DA", ")", "C2987634#ent", "<e2>", "in", "the", "caudate", "nucleus"], "h": {"id": "C1418873", "name": "C1418873#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [18, 19]}}
{"token": ["A", "five-year-old", "labrador", "bitch", "had", "whelped", "10", "pups", "three", "days", "previously", "was", "given", "booster", "vaccination", "distemper", ",", "C0001486#ent", "<e1>", ",", "parvovirus", ",", "parainfluenzavirus", "and", "C0023364#ent", "<e2>", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0023364", "name": "C0023364#ent", "pos": [24, 25]}}
{"token": ["C1335824#ent", "<e1>", ">", "CPT-11", ",", "where", "MDC", ",", "CMMDC", ",", "and", "C0142710#ent", "<e2>", "were", "over", "an", "order", "of", "magnitude", "more", "cytotoxic", "than", "C1335824#ent", "<e1>", "and", "CPT-11", "."], "h": {"id": "C1335824", "name": "C1335824#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0142710", "name": "C0142710#ent", "pos": [11, 12]}}
{"token": ["Other", "reported", "children", "with", "a", "similar", "distinctive", "clinical", "condition", "compared", "with", "adults", "with", "a", "C0039082#ent", "<e1>", "termed", "reversible", "C0878576#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0878576", "name": "C0878576#ent", "pos": [18, 19]}}
{"token": ["Indomethacin", "significantly", "increased", "C1705462#ent", "<e1>", "C0022575#ent", "<e2>", "TNF-alpha", "levels", ",", "but", "did", "not", "affect", "those", "for", "sham", "C0022575#ent", "<e2>", ",", "suggesting", "autoregulation", "by", "arachidonic", "acid", "cyclooxygenase", "metabolites", "following", "C1705462#ent", "<e1>", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705462", "name": "C1705462#ent", "pos": [3, 4]}}
{"token": ["Second", ",", "the", "human", "atherosclerotic", "coronary", "arteries", "isolated", "mainly", "from", "patients", "with", "C0018801#ent", "<e1>", "a", "condition", "that", "C2712370#ent", "<e2>", "the", "responses", "of", "coronary", "smooth", "muscle", "vasoactive", "amines"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [17, 18]}}
{"token": ["We", "obtained", "blood", "for", "measurement", "of", "C1423108#ent", "<e1>", "in", "a", "non-random", "sample", "586", "patients", "with", "C4049859#ent", "<e2>", "on", "entering", "the", "Stroke", "Prevention", "Atrial", "Fibrillation", "III", "Study", "."], "h": {"id": "C1423108", "name": "C1423108#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [15, 16]}}
{"token": ["Mutation", "of", "the", "GATA", "binding", "site", "the", "C0003805#ent", "<e1>", "promoter", "and", "inhibition", "of", "C2700223#ent", "<e2>", "expression", "with", "specific", "small", "interfering", "RNA", "significantly", "reduced", "FSH-enhanced", "C0003805#ent", "<e1>", "expression", ",", "whereas", "overexpression", "of", "C2700223#ent", "<e2>", "increased", "C0003805#ent", "<e1>", "promoter", "activity"], "h": {"id": "C2700223", "name": "C2700223#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003805", "name": "C0003805#ent", "pos": [7, 8]}}
{"token": ["The", "physiological", "roles", "played", "by", "hepatocytes", "and", "nonparenchymal", "cells", "rat", "C0023899#ent", "<e1>", "in", "the", "metabolism", "of", "C3265062#ent", "<e2>", "been", "investigated", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3265062", "name": "C3265062#ent", "pos": [16, 17]}}
{"token": ["After", "TBLB", ",", "corticosteroid", "was", "administered", "repetitively", ",", "but", "C0013404#ent", "<e1>", "was", "deteriorating", "as", "the", "ground", "glass", "opacities", "more", "widespread", ",", "and", "C0006267#ent", "<e2>", "throughout", "the", "lung", "fields"], "h": {"id": "C0013404", "name": "C0013404#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0006267", "name": "C0006267#ent", "pos": [22, 23]}}
{"token": ["The", "involvement", "of", "C0608437#ent", "<e1>", "in", "this", "third", "step", "(", "from", "C0001962#ent", "<e2>", "aldehyde", ")", "was", "demonstrated", "by", "photochemical", "action", "spectra", "and", "determination", "of", "stoichiometry", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [11, 12]}}
{"token": ["C0270958#ent", "<e1>", "characterized", "as", "atrophic", "thyroid", "gland", "positive", "autoantibodies", "thyroid", "gland", "including", "C0766868#ent", "<e2>", "."], "h": {"id": "C0270958", "name": "C0270958#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0766868", "name": "C0766868#ent", "pos": [12, 13]}}
{"token": ["Both", "alveolar", "type", "II", "cells", "alveolar", "macrophages", "be", "potential", "target", "cells", "for", "C0047964#ent", "<e1>", "toxicity", "based", "on", "their", "C0034342#ent", "<e2>", "capabilities", "."], "h": {"id": "C0047964", "name": "C0047964#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0034342", "name": "C0034342#ent", "pos": [18, 19]}}
{"token": ["To", "compare", "the", "titre", "of", "anti-ganglioside", "antibodies", "C0162311#ent", "<e1>", ")", "to", "GM1", "ganglioside", "patients", "with", "central", "and", "C0752235#ent", "<e2>", "pure", "motor", "and", "sensorimotor", "neuropathy", "in", "patients", "with", "classic", "autoimmune", "diseases", "and", "controls", "."], "h": {"id": "C0162311", "name": "C0162311#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [17, 18]}}
{"token": ["However", ",", "SDS", "interferes", "with", "other", "techniques", "used", "for", "characterization", "of", "C0086376#ent", "<e1>", ",", "such", "as", "mass", "spectrometry", "C0026269#ent", "<e2>", ")", "and", "amino", "acid", "sequencing"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [18, 19]}}
{"token": ["The", "conversion", "(", "ectodomain", "shedding", ")", "of", "C1704816#ent", "<e1>", "to", "sHB-EGF", "is", "tightly", "regulated", "by", "specific", "C0025543#ent", "<e2>", "."], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [16, 17]}}
{"token": ["An", "attenuation", "of", "adverse", "experiences", "during", "C0028066#ent", "<e1>", "monotherapy", "was", "obtained", "when", "C0105523#ent", "<e2>", "was", "added", "to", "the", "C0028066#ent", "<e1>", "regimen", "."], "h": {"id": "C0028066", "name": "C0028066#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0105523", "name": "C0105523#ent", "pos": [12, 13]}}
{"token": ["Previously", ",", "we", "have", "reported", "the", "design", "and", "characterization", "of", "a", "self-assembling", "peptide", "fiber", "(", "C2829390#ent", "<e1>", ")", "system", "based", "on", "C1539075#ent", "<e2>"], "h": {"id": "C2829390", "name": "C2829390#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1539075", "name": "C1539075#ent", "pos": [21, 22]}}
{"token": ["Common", "infections", "cervical", "lymphadenitis", "tuberculous", "lymphadenitis", "C0007361#ent", "<e1>", "infection", "in", "the", "neck", "spaces", ",", "infectious", "mononucleosis", "and", "C0039128#ent", "<e2>", "."], "h": {"id": "C0007361", "name": "C0007361#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039128", "name": "C0039128#ent", "pos": [17, 18]}}
{"token": ["Changing", "C0075632#ent", "<e1>", "resulted", "in", "2-h", "C0722420#ent", "<e2>", "25", "-", "81", "%", "in", "patients", "with", "a", "history", "of", "poor", "response", "sumatriptan", "."], "h": {"id": "C0075632", "name": "C0075632#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0722420", "name": "C0722420#ent", "pos": [6, 7]}}
{"token": ["Abnormalities", "in", "the", "sagittal", "plane", "C.F.S.", ")", "lead", "to", "C0015310#ent", "<e1>", "with", "exorbitism", ",", "the", "C0024141#ent", "<e2>", "double", "up-shoot", "."], "h": {"id": "C0015310", "name": "C0015310#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [15, 16]}}
{"token": ["Ten", "patients", "with", "large", "melanomas", "and", "one", "patient", "with", "recurrent", "retinoblastoma", "treated", "with", "localized", "current", "field", "(", "C1955822#ent", "<e1>", ")", "hyperthermia", "and", "C0885449#ent", "<e2>", "125", "irradiation", "delivered", "by", "episcleral", "plaque", "."], "h": {"id": "C1955822", "name": "C1955822#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0885449", "name": "C0885449#ent", "pos": [22, 23]}}
{"token": ["C2700171#ent", "<e1>", "Duragesic", ")", "is", "an", "C0027410#ent", "<e2>", "has", "been", "shown", "to", "be", "safe", "and", "effective", "for", "the", "treatment", "of", "cancer", "pain"], "h": {"id": "C2700171", "name": "C2700171#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027410", "name": "C0027410#ent", "pos": [6, 7]}}
{"token": ["Diabetic", "muscle", "infarction", "(", "C0011685#ent", "<e1>", ")", "is", "a", "C0030193#ent", "<e2>", "and", "potentially", "serious", "complication", "in", "patients", "with", "poorly", "controlled", "diabetes", "mellitus"], "h": {"id": "C0011685", "name": "C0011685#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [9, 10]}}
{"token": ["In", "a", "controlled", "double", "blind", "trial", "the", "symptomatic", "effect", "of", "the", "calcium", "channel", "blocker", "C0028116#ent", "<e1>", "was", "assessed", "in", "19", "patients", "with", "C0151445#ent", "<e2>", "phenomenon", "."], "h": {"id": "C0028116", "name": "C0028116#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0151445", "name": "C0151445#ent", "pos": [22, 23]}}
{"token": ["COX-2", "inhibitors", "such", "as", "C0538927#ent", "<e1>", ",", "and", "ubiquitin-proteasome", "pathway", "inhibitors", "such", "as", "bortezomib", ",", "can", "down-regulate", "C2986464#ent", "<e2>", ",", "a", "transcription", "factor", "in", "tumor", "growth"], "h": {"id": "C0538927", "name": "C0538927#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [17, 18]}}
{"token": ["Effects", "of", "doses", "of", "C0237406#ent", "<e1>", "on", "the", "C1418938#ent", "<e2>", "PRL", ")", "levels", "and", "on", "the", "ultrastructure", "of", "PRL", "cells", "in", "young", "and", "aged", "male", "Wistar", "rats", "investigated", "."], "h": {"id": "C0237406", "name": "C0237406#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [8, 9]}}
{"token": ["C1709830#ent", "<e1>", "is", "an", "C0021699#ent", "<e2>", "localizes", "to", "CNS", ",", "but", "not", "peripheral", "nervous", "system", "myelin", "."], "h": {"id": "C1709830", "name": "C1709830#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [4, 5]}}
{"token": ["Vibrio", "cholerae", "neuraminidase", "VCNA", ")", "plays", "a", "significant", "role", "in", "the", "pathogenesis", "of", "C0008354#ent", "<e1>", "by", "removing", "sialic", "acid", "higher", "order", "C0017082#ent", "<e2>", "to", "unmask", "GM1", ",", "the", "receptor", "for", "cholera", "toxin"], "h": {"id": "C0008354", "name": "C0008354#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017082", "name": "C0017082#ent", "pos": [21, 22]}}
{"token": ["The", "effects", "of", "C1367721#ent", "<e1>", "and", "estradiol", "were", "not", "additive", ",", "suggesting", "that", "C1367721#ent", "<e1>", "and", "estradiol", "are", "acting", "through", "common", "mechanisms", "where", "C0752229#ent", "<e1>", "could", "possibly", "intervene", "."], "h": {"id": "C1367721", "name": "C1367721#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752229", "name": "C0752229#ent", "pos": [23, 24]}}
{"token": ["Twenty-four", "C0235267#ent", "<e1>", "removed", "for", "complications", "of", "C0022570#ent", "<e2>", "studied", "histopathologically", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022570", "name": "C0022570#ent", "pos": [7, 8]}}
{"token": ["C3536793#ent", "<e1>", "ARB", ")", ",", "another", "C0033613#ent", "<e2>", "can", "decrease", "podocyte", "loss", "in", "DN", "."], "h": {"id": "C3536793", "name": "C3536793#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033613", "name": "C0033613#ent", "pos": [6, 7]}}
{"token": ["The", "culture", "supernatants", "were", "negative", "for", "IL-1beta", "and", "C0812246#ent", "<e1>", ",", "which", "demonstrates", "that", "C1332789#ent", "<e2>", "did", "not", "activate", "the", "macrophages", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332789", "name": "C1332789#ent", "pos": [14, 15]}}
{"token": ["WAY100635", "antagonized", "the", "effect", "of", "C0380393#ent", "<e1>", "and", "of", "aripiprazole", "but", "only", "slightly", "attenuated", "that", "of", "C0009079#ent", "<e2>", "."], "h": {"id": "C0380393", "name": "C0380393#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009079", "name": "C0009079#ent", "pos": [16, 17]}}
{"token": ["This", "study", "examined", "the", "effects", "of", "NPY", "on", "seizures", "and", "C1706584#ent", "<e1>", "elicited", "in", "hippocampal", "C1413044#ent", "<e2>", "."], "h": {"id": "C1706584", "name": "C1706584#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413044", "name": "C1413044#ent", "pos": [15, 16]}}
{"token": ["Experiments", "were", "carried", "out", "to", "assess", "the", "susceptibility", "of", "normal", "and", "C0021390#ent", "<e1>", "rectal", "mucus", "desulphation", "and", "desialation", "by", "faecal", "extracts", "and", "by", "C0027803#ent", "<e2>"], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027803", "name": "C0027803#ent", "pos": [23, 24]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "influence", "of", "cPLA2", "and", "secreted", "phospholipase", "A2", "C1706169#ent", "<e1>", ")", "Group", "IIA", ",", "Group", "V", "and", "Group", "X", "C1705592#ent", "<e2>", "and", "COX-2", "expression", "in", "human", "lung", "epithelial", "cells", "A549", "cells", "."], "h": {"id": "C1706169", "name": "C1706169#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [24, 25]}}
{"token": ["Fifty", "patients", "suffering", "from", "C0008679#ent", "<e1>", "treated", "for", "30", "days", "with", "C0086647#ent", "<e2>", "mg", "per", "os", ",", "b.i.d", ".", ","], "h": {"id": "C0008679", "name": "C0008679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086647", "name": "C0086647#ent", "pos": [11, 12]}}
{"token": ["On", "6", "properties", "in", "south-western", "Queensland", "an", "outbreak", "of", "C0007682#ent", "<e1>", "horses", "due", "to", "ingestion", "of", "C0085535#ent", "<e2>", "Darling", "pea", "."], "h": {"id": "C0007682", "name": "C0007682#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085535", "name": "C0085535#ent", "pos": [16, 17]}}
{"token": ["Pre-treatment", "of", "cells", "with", "C0011816#ent", "<e1>", "inhibited", "apoptosis", "induced", "by", "staurosporine", ",", "C0015133#ent", "<e2>", "and", "thapsigargin", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015133", "name": "C0015133#ent", "pos": [12, 13]}}
{"token": ["Mortality", "and", "post-operative", "complications", "are", "elevated", "in", "C0010346#ent", "<e1>", "for", "many", "reasons", ":", "pre-existing", "septic", "complications", ",", "C0162429#ent", "<e2>", ",", "impaired", "cell-mediated", "immunity", "failure", "to", "identify", "enteric", "fistulas", "abdominal", "abscess", "surgical", "operation", "."], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [17, 18]}}
{"token": ["We", "have", "demonstrated", "that", "amyloid", "beta", "C1705543#ent", "<e1>", ")", ",", "which", "is", "deposited", "in", "C1260959#ent", "<e2>", ",", "causes", "an", "imbalance", "in", "the", "angiogenesis-related", "factors", "in", "retinal", "pigment", "epithelial", "cells"], "h": {"id": "C1705543", "name": "C1705543#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1260959", "name": "C1260959#ent", "pos": [14, 15]}}
{"token": ["C0025023#ent", "<e1>", "was", "tested", "for", "its", "efficacy", "in", "individual", "treatment", "mass", "control", "C0040954#ent", "<e2>", "Korea", "."], "h": {"id": "C0025023", "name": "C0025023#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0040954", "name": "C0040954#ent", "pos": [12, 13]}}
{"token": ["C0686347#ent", "<e1>", "TD", ")", "is", "an", "adverse", "effect", "several", "C0033978#ent", "<e2>", "long-term", "therapy", "for", "schizophrenia", "and", "other", "psychoses", "."], "h": {"id": "C0686347", "name": "C0686347#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [9, 10]}}
{"token": ["The", "Michaelis", "constant", "was", "1.58", "10(-3", ")", "M/L.", "C1424288#ent", "<e1>", "was", "inhibited", "by", "L-homoarginine", "and", "C0023556#ent", "<e2>", "but", "not", "by", "L-phenylalanine", "."], "h": {"id": "C1424288", "name": "C1424288#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023556", "name": "C0023556#ent", "pos": [15, 16]}}
{"token": ["While", "organic", "nitrogen", "increased", "activities", "of", "acetyl-CoA", "carboxylase", "ACC", ")", "and", "C0065558#ent", "<e1>", "ME", ")", ",", "ATP", ":", "citrate", "lyase", "C1412125#ent", "<e2>", ")", "was", "rapidly", "enhanced", "by", "ammonium", "ion"], "h": {"id": "C0065558", "name": "C0065558#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412125", "name": "C1412125#ent", "pos": [20, 21]}}
{"token": ["The", "18", "amino", "acid", "COOH", "terminus", "of", "the", "56-kDa", "subunit", "of", "the", "C0018440#ent", "<e1>", "NHERF-1", "and", "NBC3", ",", "but", "the", "truncated", "and", "modified", "C0030956#ent", "<e2>", "did", "not", "."], "h": {"id": "C0018440", "name": "C0018440#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [23, 24]}}
{"token": ["A", "56-year-old", "woman", "with", "C0038013#ent", "<e1>", "RA", ")", "suddenly", "developed", "severe", "respiratory", "distress", "C0023066#ent", "<e2>", "which", "required", "endotracheal", "intubation"], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023066", "name": "C0023066#ent", "pos": [13, 14]}}
{"token": ["Together", ",", "our", "data", "indicate", "that", "targeting", "of", "the", "C1706172#ent", "<e1>", "histone", "deacetylase", "osmoresponsive", "promoters", "by", "the", "MAPK", "C3889446#ent", "<e2>", "is", "required", "to", "induce", "gene", "expression", "stress", "."], "h": {"id": "C1706172", "name": "C1706172#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [18, 19]}}
{"token": ["Increased", "expression", "of", "IL-1alpha", "mRNA", "by", "C0055721#ent", "<e1>", "was", "not", "linked", "to", "resorption", "stimulated", "by", "the", "C0289779#ent", "<e2>", "."], "h": {"id": "C0055721", "name": "C0055721#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0289779", "name": "C0289779#ent", "pos": [16, 17]}}
{"token": ["C1332679#ent", "<e1>", "also", "induced", "the", "transient", "expression", "of", "C0812246#ent", "<e2>", ",", "IL-8", ",", "and", "MCP-1", "within", "15", "min", "of", "the", "treatment", "of", "the", "THP-1", "cells", "."], "h": {"id": "C1332679", "name": "C1332679#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [8, 9]}}
{"token": ["In", "normal", "nucleus", "interpeduncularis", "activities", "of", "carnitine", "acetyltransferase", "pyruvate", "dehydrogenase", "complex", "higher", "than", "the", "activity", "of", "C4082365#ent", "<e1>", "(", "choline", "acetyltransferase", ",", "whereas", "the", "activities", "of", "acetyl-CoA", "synthetase", "C0008855#ent", "<e2>", "considerably", "lower", "than", "that", "of", "C4082365#ent", "<e1>", "."], "h": {"id": "C4082365", "name": "C4082365#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008855", "name": "C0008855#ent", "pos": [28, 29]}}
{"token": ["Initial", "studies", "indicated", "that", "neutrophils", "provided", "C1425280#ent", "<e1>", "in", "vitro", "rapidly", "elongate", "it", "(", "by", "two", "C0524928#ent", "<e2>", ")", "to", "dihomogammalinolenic", "acid", "DGLA", ")", "."], "h": {"id": "C1425280", "name": "C1425280#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [16, 17]}}
{"token": ["Amyloidosis", "is", "the", "most", "significant", "complication", "of", "C0031069#ent", "<e1>", ",", "leading", "to", "end", "stage", "renal", "disease", "C0035078#ent", "<e2>", ")", "."], "h": {"id": "C0031069", "name": "C0031069#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0035078", "name": "C0035078#ent", "pos": [16, 17]}}
{"token": ["We", "hypothesized", "that", "transcatheter", "left", "atrial", "(", "LA", ")", "decompression", "in", "C0152101#ent", "<e1>", "with", "rAS", "would", "safely", "and", "effectively", "relieve", "C0235222#ent", "<e2>", "improve", "oxygenation", ",", "and", "improve", "Norwood", "survival", "."], "h": {"id": "C0152101", "name": "C0152101#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0235222", "name": "C0235222#ent", "pos": [20, 21]}}
{"token": ["Antibodies", "against", "the", "glial", "fibrillary", "acidic", "protein", "the", "microglia/brain", "macrophage", "epitope", "C0162359#ent", "<e1>", "were", "used", "to", "detect", "colocalization", "of", "C0669372#ent", "<e2>", "astrocytes", "or", "activated", "microglia/brain", "macrophages", ",", "respectively", "."], "h": {"id": "C0162359", "name": "C0162359#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [19, 20]}}
{"token": ["Phosphorylation", "of", "C1423495#ent", "<e1>", "and", "pp105", "was", "established", "with", "C1705556#ent", "<e2>", "as", "well", "as", "with", "GTP", "and", "was", "not", "dependent", "on", "cyclic", "nucleotides", "cyclic", "AMP", "cyclic", "GMP", "cyclic", "CMP"], "h": {"id": "C1423495", "name": "C1423495#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [9, 10]}}
{"token": ["Similarly", ",", "C1823480#ent", "<e1>", "may", "serve", "to", "target", "C1417945#ent", "<e2>", "to", "GABA(A)", "receptor", "for", "mediating", "GABA", "signaling", "cascades"], "h": {"id": "C1823480", "name": "C1823480#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417945", "name": "C1417945#ent", "pos": [8, 9]}}
{"token": ["Here", "we", "use", "viral-mediated", "RNA", "interference", "RNAi", ")", "to", "generate", "a", "specific", "knockdown", "of", "C4285344#ent", "<e1>", ",", "the", "gene", "encoding", "the", "dopamine", "synthesis", "C1420718#ent", "<e2>", "within", "midbrain", "neurons", "of", "adult", "mice", "."], "h": {"id": "C4285344", "name": "C4285344#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420718", "name": "C1420718#ent", "pos": [23, 24]}}
{"token": ["Peroxidase-antiperoxidase", "immunohistology", "consistent", "positive", "reaction", "C0031667#ent", "<e1>", "lipase", "and", "C0009304#ent", "<e2>", "at", "the", "border", "of", "fat", "necrosis", "pancreatic", "interlobular", "adipose", "tissue", "in", "peripancreatic", ",", "mesenterial", "and", "retroperitoneal", "fat"], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009304", "name": "C0009304#ent", "pos": [9, 10]}}
{"token": ["Neither", "Ca-free", "media", "nor", "a", "variety", "of", "C1562036#ent", "<e1>", "the", "ACh", "or", "C0009014#ent", "<e2>", "inhibitions", "."], "h": {"id": "C1562036", "name": "C1562036#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0009014", "name": "C0009014#ent", "pos": [12, 13]}}
{"token": ["It", "includes", "at", "least", "four", "distinct", "genetic", "entities", ":", "ataxia-telangiectasia", ",", "C1858391#ent", "<e1>", "and", "ataxia", "with", "oculomotor", "apraxia", "type", "1", "C1859598#ent", "<e2>", ")", "and", "type", "2", "AOA2", ")", "."], "h": {"id": "C1858391", "name": "C1858391#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1859598", "name": "C1859598#ent", "pos": [20, 21]}}
{"token": ["Genes", "encoding", "C0066357#ent", "<e1>", "MTHFR", ")", "or", "methylenetetrahydrofolate", "dehydrogenase", "C3541989#ent", "<e2>", ")", "belong", "to", "the", "first", "group", "."], "h": {"id": "C0066357", "name": "C0066357#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541989", "name": "C3541989#ent", "pos": [9, 10]}}
{"token": ["Presentation", "of", "six", "drugs", ":", "clopidogrel", ",", "C0618111#ent", "<e1>", ",", "mecillinam", ",", "natiglinide", "and", "C0246689#ent", "<e2>", ",", "pneumococcal", "conjugate", "vaccine"], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0246689", "name": "C0246689#ent", "pos": [14, 15]}}
{"token": ["Each", "mutation", "cosegregated", "with", "the", "phenotype", "of", "C0011848#ent", "<e1>", "supposed", "to", "be", "a", "cause", "for", "resistance", "to", "C1366535#ent", "<e2>"], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [7, 8]}, "relation": "disease_has_associated_gene", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [17, 18]}}
{"token": ["C0235025#ent", "<e1>", "an", "inflammatory", ",", "demyelinating", "neuropathy", ",", "like", "chronic", "inflammatory", "demyelinating", "polyneuropathy", "C2697642#ent", "<e2>", ")", ",", "is", "probably", "immune-mediated", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697642", "name": "C2697642#ent", "pos": [13, 14]}}
{"token": ["C0038363#ent", "<e1>", "a", "common", "and", "C0030193#ent", "<e2>", "problem", "."], "h": {"id": "C0038363", "name": "C0038363#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [5, 6]}}
{"token": ["D.", "africanus", "C1710596#ent", "<e1>", "is", "a", "256", "kDa", "homodimer", "which", "contains", "C0039847#ent", "<e2>", "TPP", ")", "and", "iron-sulfur", "clusters"], "h": {"id": "C1710596", "name": "C1710596#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039847", "name": "C0039847#ent", "pos": [11, 12]}}
{"token": ["Absence", "of", "oxygen", "or", "decreased", "cellular", "ATP", "content", "(", "e.g.", ",", "by", "C0003015#ent", "<e1>", "xylulose", ")", "blocks", "hepatocellular", "uptake", "of", "C1414386#ent", "<e2>", "51921", "."], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414386", "name": "C1414386#ent", "pos": [20, 21]}}
{"token": ["After", "informed", "consent", "was", "obtained", "and", "with", "the", "approval", "of", "the", "Local", "Ethical", "Committee", "cyclosporine", "A", "C0751039#ent", "<e1>", ")", "kinetics", "was", "studied", "in", "63", "C0003872#ent", "<e2>", "patients", "by", "giving", "them", "2.5", "mg/kg", "C0751039#ent", "<e1>", "orally", "."], "h": {"id": "C0003872", "name": "C0003872#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [16, 17]}}
{"token": ["Smoking", "can", "also", "improve", "C0015371#ent", "<e1>", "secondary", "effects", "of", "antipsychotic", "medication", "it", "induces", "C0207509#ent", "<e2>", "an", "enzyme", "system", "in", "the", "metabolism", "of", "several", "antipsychotics", "."], "h": {"id": "C0015371", "name": "C0015371#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0207509", "name": "C0207509#ent", "pos": [13, 14]}}
{"token": ["The", "data", "on", "combined", "treatment", "CGP", "37849", "and", "C0037567#ent", "<e1>", "substantiate", "that", "kindling", "alters", "the", "susceptibility", "to", "manipulations", "of", "C0022614#ent", "<e2>", "receptor-mediated", "events", "."], "h": {"id": "C0037567", "name": "C0037567#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [19, 20]}}
{"token": ["Classical", "C0694577#ent", "<e1>", "in", "11", "patients", "whilst", "the", "C0003864#ent", "<e2>", "in", "the", "remaining", "21", "was", "additive", "in", "type", ",", "rapidly", "becoming", "symmetrical", "."], "h": {"id": "C0694577", "name": "C0694577#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [8, 9]}}
{"token": ["We", "describe", "a", "54-year-old", "man", "with", "dominant", "adult-onset", "C1851920#ent", "<e1>", "DRD", ")", "with", "C0242422#ent", "<e2>", "caused", "by", "an", "Arg184His", "mutation", "in", "guanosine", "5'-triphosphate", "cyclohydrolase", "I", "GCH-I", ")", "."], "h": {"id": "C1851920", "name": "C1851920#ent", "pos": [8, 9]}, "relation": "has_manifestation", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [13, 14]}}
{"token": ["There", "were", "minor", "but", "significant", "changes", "in", "C3887648#ent", "<e1>", ",", "renin", "and", "systolic", "pressure", "multiple", "dose", "clonidine", "and", "C3540782#ent", "<e2>", "and", "in", "renin", ",", "heart", "rate", "systolic", "and", "diastolic", "pressure", "propranolol", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540782", "name": "C3540782#ent", "pos": [18, 19]}}
{"token": ["And", "5-HT(6", ")", "receptor", "gene", "(", "C1415815#ent", "<e1>", ")", "variants", "may", "be", "a", "genetic", "risk", "factor", "C0002395#ent", "<e2>", "LOAD", ")", "."], "h": {"id": "C1415815", "name": "C1415815#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [16, 17]}}
{"token": ["Using", "isotopic", "in", "situ", "hybridization", "immunohistochemistry", ",", "we", "have", "localized", "the", "expression", "of", "hGH", "receptor", "(", "hGHR", ")", "and", "C1706337#ent", "<e1>", "hPRLR", ")", "in", "a", "panel", "of", "human", "C0006145#ent", "<e2>"], "h": {"id": "C1706337", "name": "C1706337#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0006145", "name": "C0006145#ent", "pos": [28, 29]}}
{"token": ["The", "aim", "of", "this", "study", "is", "to", "determine", "whether", "the", "degree", "of", "C1456654#ent", "<e1>", "correlated", "with", "lumbar", "spine", "C1414083#ent", "<e2>"], "h": {"id": "C1456654", "name": "C1456654#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [18, 19]}}
{"token": ["In", "vitro", "stimulation", "with", "C1419805#ent", "<e1>", "resulted", "in", "an", "increase", "in", "interleukin", "(IL)-2", "C1334119#ent", "<e2>", ",", "IL-5", ",", "and", "tumor", "necrosis", "factor-alpha", "mRNA", "cytokine", "expression", "from", "splenocytes", "of", "infected", "BALB/cGKO", "mice", "."], "h": {"id": "C1419805", "name": "C1419805#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334119", "name": "C1334119#ent", "pos": [13, 14]}}
{"token": ["On", "the", "contrary", ",", "isoprenaline", "produced", "an", "increase", "in", "C1537486#ent", "<e1>", "which", "was", "attenuated", "by", "C0033497#ent", "<e2>", "."], "h": {"id": "C1537486", "name": "C1537486#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [15, 16]}}
{"token": ["Although", "an", "IgE-mediated", "type-1", "hypersensitivity", "reaction", "been", "demonstrated", "or", "postulated", "in", "many", "types", "of", "C0015397#ent", "<e1>", "the", "pathophysiology", "underlying", "the", "C0009763#ent", "<e2>", "not", "fully", "understood", "."], "h": {"id": "C0015397", "name": "C0015397#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "epidemiological", "studies", "that", "high", "C1415467#ent", "<e1>", "intake", "might", "have", "protective", "properties", "C0524851#ent", "<e2>"], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0524851", "name": "C0524851#ent", "pos": [13, 14]}}
{"token": ["C3696376#ent", "<e1>", "detected", "in", "four", "patients", "with", "C0342784#ent", "<e2>", "a", "multitissue", "disorder", "with", "hematologic", "abnormalities", "lactic", "acidosis", "from", "defective", "oxidative", "phosphorylation", "and", "deletions", "in", "the", "mitochondrial", "genome"], "h": {"id": "C3696376", "name": "C3696376#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0342784", "name": "C0342784#ent", "pos": [7, 8]}}
{"token": ["Members", "of", "the", "cdc25", "family", "are", "C1956003#ent", "<e1>", "play", "pivotal", "roles", "in", "C1539078#ent", "<e2>"], "h": {"id": "C1956003", "name": "C1956003#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [12, 13]}}
{"token": ["Polysomnographic", "recordings", "performed", "in", "50", "children", "free", "from", "any", "familial", "or", "personal", "history", "seizure", "or", "C0027765#ent", "<e1>", "evaluate", "the", "frequency", "of", "C0040997#ent", "<e2>", "and", "unusual", "electroencephalographic", "patterns", "a", "normal", "population"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0040997", "name": "C0040997#ent", "pos": [21, 22]}}
{"token": ["C3711796#ent", "<e1>", "is", "found", "in", "many", "ethnic", "groups", "and", "is", "C1516876#ent", "<e2>", "heterogeneous", ":", "four", "complementation", "groups", "have", "been", "identified", "in", "C3711796#ent", "<e1>", "so", "far", "."], "h": {"id": "C3711796", "name": "C3711796#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [10, 11]}}
{"token": ["Both", "C0035690#ent", "<e1>", "used", "to", "study", "oral", "treatment", "C0874161#ent", "<e2>", "and", "ribavirin", ",", "both", "alone", "and", "in", "combination", "."], "h": {"id": "C0035690", "name": "C0035690#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0874161", "name": "C0874161#ent", "pos": [8, 9]}}
{"token": ["Timentin", "(", "ticarcillin", "+", "clavulanic", "acid", "combined", "with", "an", "C3536835#ent", "<e1>", "usually", "netilmicin", ",", "was", "given", "to", "33", "children", "with", "C0023530#ent", "<e2>", "haematological", "malignancies"], "h": {"id": "C3536835", "name": "C3536835#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [20, 21]}}
{"token": ["Serial", "consecutive", "sections", "were", "stained", "for", "AChE", ",", "C2678065#ent", "<e1>", "after", "alkaline", "and", "acid", "preincubation", ")", ",", "and", "C0010760#ent", "<e2>"], "h": {"id": "C2678065", "name": "C2678065#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010760", "name": "C0010760#ent", "pos": [18, 19]}}
{"token": ["Chlorpromazine", ",", "trifluoperazine", ",", "C0039943#ent", "<e1>", ",", "chlorprothixene", "and", "C0002600#ent", "<e2>", "inhibited", "amylase", "secretion", "stimulated", "by", "carbachol", ",", "A-23187", ",", "and", "cholecystokinin-pancreozymin", "but", "not", "that", "elicited", "by", "dibutyryl", "cyclic", "AMP", "secretin", "vasoactive", "intestinal", "peptide", "VIP", ")", "."], "h": {"id": "C0039943", "name": "C0039943#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [9, 10]}}
{"token": ["In", "the", "neuron", ",", "soluble", "C1417599#ent", "<e1>", "SNARE", ")", "proteins", "assemble", "into", "an", "C3275243#ent", "<e2>", "bridges", "the", "synaptic", "vesicle", "the", "plasma", "membrane", "drives", "membrane", "fusion", "a", "required", "process", "for", "neurotransmitter", "release", "at", "the", "nerve", "terminal"], "h": {"id": "C1417599", "name": "C1417599#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3275243", "name": "C3275243#ent", "pos": [13, 14]}}
{"token": ["C0030409#ent", "<e1>", "may", "be", "effectively", "treated", "with", "prolonged", "and", "sometimes", "life-long", "C0064113#ent", "<e2>", "or", "fluconazole", "therapy", "."], "h": {"id": "C0030409", "name": "C0030409#ent", "pos": [0, 1]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [11, 12]}}
{"token": ["The", "activities", "of", "C0003448#ent", "<e1>", "evaluated", "in", "a", "murine", "C0041296#ent", "<e2>", "model", "using", "a", "drug-resistant", "isolate", "."], "h": {"id": "C0003448", "name": "C0003448#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [9, 10]}}
{"token": ["Standard", "C0003448#ent", "<e1>", "extremely", "effective", "in", "treating", "C0041296#ent", "<e2>", "in", "this", "setting", "."], "h": {"id": "C0003448", "name": "C0003448#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [7, 8]}}
{"token": ["Our", "purpose", "was", "to", "establish", "the", "efficacy", "of", "human", "fibrin", "glue", "C1841679#ent", "<e1>", ")", "in", "preventing", "coagulative", "complications", "inguinal", "hernia", "repair", "patients", "with", "C0600503#ent", "<e2>"], "h": {"id": "C1841679", "name": "C1841679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0600503", "name": "C0600503#ent", "pos": [23, 24]}}
{"token": ["To", "assess", "possible", "peripheral", "effects", "intracerebroventricular", "C0287041#ent", "<e1>", ",", "one", "set", "of", "C0018802#ent", "<e2>", "rats", "received", "the", "same", "rate", "of", "C0287041#ent", "<e1>", "subcutaneously", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [6, 7]}}
{"token": ["In", "C0018802#ent", "<e1>", "rats", ",", "the", "same", "rate", "of", "infusion", "of", "C0287041#ent", "<e2>", "subcutaneously", "was", "ineffective", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [11, 12]}}
{"token": ["These", "data", "indicate", "the", "presence", "of", "a", "modulated", "enzyme-enzyme", "interaction", "between", "FBPase", "and", "isoenzyme", "B.", "affirm", "that", "in", "kidney", ",", "C0001999#ent", "<e1>", "participates", ",", "along", "the", "gluconeogenic", "pathway", "and", "C1412344#ent", "<e2>", "glycolysis", "."], "h": {"id": "C0001999", "name": "C0001999#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1412344", "name": "C1412344#ent", "pos": [29, 30]}}
{"token": ["We", "show", "that", "this", "mutation", "abolishes", "the", "binding", "of", "C0812231#ent", "<e1>", "in", "vitro", "leads", "to", "a", "high", "C0907533#ent", "<e2>", ",", "poorly", "regulated", "L-ferritin", "synthesis", "in", "cultured", "lymphoblastoid", "cells", "from", "affected", "patients", "."], "h": {"id": "C0812231", "name": "C0812231#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [17, 18]}}
{"token": ["Improvement", "of", "efficacy", "of", "C0279175#ent", "<e1>", "inducing", "longlasting", "remission", "of", "C0339143#ent", "<e2>", "therefore", "been", "an", "elusive", "goal", "."], "h": {"id": "C0279175", "name": "C0279175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "evaluate", "the", "screening", "of", "a", "group", "of", "short-stature", "girls", "for", "C0040963#ent", "<e1>", "based", "on", "the", "number", "of", "CAG", "repeats", "the", "C1367578#ent", "<e2>", "by", "GeneScan", "software"], "h": {"id": "C0040963", "name": "C0040963#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1367578", "name": "C1367578#ent", "pos": [28, 29]}}
{"token": ["These", "findings", "suggest", "that", "insulin", "secretion", "response", "to", "C0475718#ent", "<e1>", "is", "stimulated", "by", "spinal", "analgesia", "thiopentone", "anaesthesia", "depressed", "by", "C0018549#ent", "<e2>", "and", "enflurane", "anaesthesia", "unchanged", "during", "neuroleptanesthesia", "."], "h": {"id": "C0475718", "name": "C0475718#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0018549", "name": "C0018549#ent", "pos": [19, 20]}}
{"token": ["Wild-type", "gp160", "and", "gp160A123", "induced", "comparable", "T", "cell", "responses", "to", "those", "of", "epitopes", "which", "with", "respect", "to", "the", "secondary", "structure", "C1414406#ent", "<e1>", "were", "distant", "from", "the", "deleted", "C0032594#ent", "<e2>", "."], "h": {"id": "C1414406", "name": "C1414406#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [27, 28]}}
{"token": ["Large", "amounts", "of", "cholesteryl", "esters", "bound", "to", "cytoplasmic", "membranes", "permanently", "affected", "by", "C0020289#ent", "<e1>", "repeated", "re-esterification", "by", "C1412111#ent", "<e2>", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412111", "name": "C1412111#ent", "pos": [17, 18]}}
{"token": ["These", "movements", "were", "not", "expressed", "by", "animals", "treated", "with", "C0244821#ent", "<e1>", "or", "KW-6002", "at", "doses", "that", "improved", "forelimb", "C0085623#ent", "<e2>", "."], "h": {"id": "C0244821", "name": "C0244821#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085623", "name": "C0085623#ent", "pos": [18, 19]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "evaluate", "the", "premise", "(", "Jenzano", "1992", ")", "that", "C2936882#ent", "<e1>", "influences", "the", "female", "mixed", "saliva", "kallikrein", "level", "(", "C1420279#ent", "<e2>", ")", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1420279", "name": "C1420279#ent", "pos": [25, 26]}}
{"token": ["C1413697#ent", "<e1>", "CRABP", ")", "are", "cytoplasmic", "proteins", "bind", "C0338222#ent", "<e2>", "RA", ")", "and", "other", "retinoids", "."], "h": {"id": "C1413697", "name": "C1413697#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0338222", "name": "C0338222#ent", "pos": [8, 9]}}
{"token": ["Several", "N-acyl-Gly-", "and", "N-blocked-boroPro", "compounds", "showed", "low", "nanomolar", "inhibitory", "activity", "fibroblast", "activation", "protein", "FAP", ")", "and", "C1418885#ent", "<e1>", "POP", ")", "and", "selectivity", "against", "dipeptidyl", "peptidase-4", "C1447020#ent", "<e2>", ")", "."], "h": {"id": "C1418885", "name": "C1418885#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1447020", "name": "C1447020#ent", "pos": [25, 26]}}
{"token": ["C3537143#ent", "<e1>", "is", "inactivated", "with", "C2744579#ent", "<e2>", "plus", "crude", "extract", "of", "Escherichia", "coli", "macrolide", "2'-phosphotransferase", "MPH(2", "'", ")", ")", ",", "but", "not", "by", "living", "cells"], "h": {"id": "C3537143", "name": "C3537143#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [5, 6]}}
{"token": ["Protein", "B", "shown", "to", "prevent", "electron", "transfer", "protein", "C", "C0220304#ent", "<e1>", "the", "absence", "of", "C0067320#ent", "<e2>", "."], "h": {"id": "C0220304", "name": "C0220304#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0067320", "name": "C0067320#ent", "pos": [14, 15]}}
{"token": ["The", "mechanisms", "that", "account", "for", "nonantioxidant", "effects", "of", "AT", "include", "the", "inhibition", "of", "C0033634#ent", "<e1>", "5-lipoxygenase", ",", "tyrosine-kinase", "as", "well", "as", "C0387583#ent", "<e2>", "."], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0387583", "name": "C0387583#ent", "pos": [21, 22]}}
{"token": ["beta-glucuronidase", ",", "beta-N-acetyl", "glucosaminidase", "C1332805#ent", "<e1>", "liver", ",", "kidney", "and", "spleen", "and", "urinary", "excretion", "C0019484#ent", "<e2>", "and", "uronic", "acid"], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0019484", "name": "C0019484#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "dexamethasone", ",", "C3539616#ent", "<e1>", ",", "TNFalpha", "and", "C0022245#ent", "<e2>", "were", "time-", "and", "dose-dependent", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [10, 11]}}
{"token": ["beta", "1", "beta", "2", "receptor", "C2362546#ent", "<e1>", "similar", "in", "TGR", ",", "SHR", "and", "C1413085#ent", "<e2>", "."], "h": {"id": "C2362546", "name": "C2362546#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413085", "name": "C1413085#ent", "pos": [13, 14]}}
{"token": ["The", "p38", "inhibitor", "SB203580", "and", "the", "ERK", "inhibitor", "C0755562#ent", "<e1>", "reduced", "not", "only", "AP-1", "activity", ",", "but", "also", "decreased", "C1705592#ent", "<e2>", "and", "MCP-1", "expression", "."], "h": {"id": "C0755562", "name": "C0755562#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [19, 20]}}
{"token": ["Furthermore", "C0755562#ent", "<e1>", "treatment", "entirely", "blocked", "nerve", "growth", "C1705592#ent", "<e2>", "ERK1/2", "activation", "in", "MGC", ",", "as", "well", "as", "FGF2-induced", "ERK1/2", "activation", "in", "cerebral", "glial", "cells"], "h": {"id": "C0755562", "name": "C0755562#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [8, 9]}}
{"token": ["The", "Japanese", "female", "patient", "presented", "here", "with", "C2020284#ent", "<e1>", "characterized", "by", "a", "flat", "midface", "had", "high", "myopia", "C0018784#ent", "<e2>", "enlarged", "joints", "and", "cleft", "of", "the", "soft", "palate"], "h": {"id": "C2020284", "name": "C2020284#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "C1420459#ent", "<e1>", "had", "no", "effect", "LPS-induced", "C1413285#ent", "<e2>", "and", "p40", "promoter", "activity", "diminished", "IFN-gamma/LPS-induced", "C1413285#ent", "<e2>", "promoter", "activity"], "h": {"id": "C1420459", "name": "C1420459#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413285", "name": "C1413285#ent", "pos": [9, 10]}}
{"token": ["Luminal", "C3540772#ent", "<e1>", "thus", "play", "an", "insignifcant", "role", "in", "the", "terminal", "digestion", "C0030956#ent", "<e2>", "in", "the", "jejunum", ",", "but", "have", "a", "much", "more", "important", "role", "in", "the", "ileal", "digestion", "C0030956#ent", "<e2>", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["A", "sample", "of", "neurones", "(", "n", "=", "7", ")", "that", "responded", "to", "the", "C1705645#ent", "<e1>", "agonist", "were", "morphologically", "characterised", "after", "filling", "with", "the", "intracellular", "dye", "C0053653#ent", "<e2>", "."], "h": {"id": "C1705645", "name": "C1705645#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0053653", "name": "C0053653#ent", "pos": [25, 26]}}
{"token": ["The", "Syk", "family", "of", "C0031727#ent", "<e1>", ",", "consisting", "of", "C1527940#ent", "<e2>", "and", "Syk", ",", "play", "essential", "roles", "in", "a", "variety", "of", "immune", "and", "non-immune", "cells", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1527940", "name": "C1527940#ent", "pos": [9, 10]}}
{"token": ["Mutation", "in", "the", "C1412058#ent", "<e1>", "D1", ",", "but", "not", "C1414052#ent", "<e2>", ",", "domain", "abolishes", "the", "ATP", "acceleration", "effect", "and", "further", "delays", "the", "reassembly", "."], "h": {"id": "C1412058", "name": "C1412058#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414052", "name": "C1414052#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "the", "efficacy", "and", "safety", "of", "a", "standardized", "willow", "bark", "extract", "in", "patients", "with", "C0029408#ent", "<e1>", "(", "OA", ")", "and", "rheumatoid", "arthritis", "C0003873#ent", "<e2>", ")", "."], "h": {"id": "C0029408", "name": "C0029408#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [23, 24]}}
{"token": ["C0012694#ent", "<e1>", "seem", "to", "reduce", "the", "exacerbations", "of", "C0013595#ent", "<e2>", "by", "food", "allergens"], "h": {"id": "C0012694", "name": "C0012694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013595", "name": "C0013595#ent", "pos": [8, 9]}}
{"token": ["Many", "C0086376#ent", "<e1>", "and", "RNAs", "associated", "with", "C2349178#ent", "<e2>", "excluded", "from", "A3G-containing", "virions", ",", "implying", "that", "C2349178#ent", "<e2>", "partitions", "into", "virions", "based", "on", "affinity", "for", "HIV-1", "RNA"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2349178", "name": "C2349178#ent", "pos": [7, 8]}}
{"token": ["Here", "we", "show", "that", "TAK1", ",", "a", "member", "of", "the", "C1367798#ent", "<e1>", "is", "activated", "by", "treatment", "of", "cells", "with", "C0991617#ent", "<e2>", "and", "stresses", "that", "induce", "an", "increase", "in", "ceramide", "."], "h": {"id": "C1367798", "name": "C1367798#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [19, 20]}}
{"token": ["We", "speculate", "that", "C0700580#ent", "<e1>", "prove", "beneficial", "for", "the", "treatment", "of", "rhinorrhea", "in", "C0035457#ent", "<e2>"], "h": {"id": "C0700580", "name": "C0700580#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0035457", "name": "C0035457#ent", "pos": [13, 14]}}
{"token": ["As", "such", ",", "we", "propose", "that", "our", "patients", "represent", "either", "a", "new", "dysmorphic", "syndrome", "a", "thus", "far", "unrecognized", "variation", "of", "a", "known", "C0039082#ent", "<e1>", ",", "such", "as", "C1846009#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [22, 23]}, "relation": "nichd_parent_of", "t": {"id": "C1846009", "name": "C1846009#ent", "pos": [27, 28]}}
{"token": ["In", "addition", ",", "C0022350#ent", "<e1>", ",", "intravascular", "haemolysis", "sepsis", "were", "responsible", "for", "C1705280#ent", "<e2>", "in", "64.2", "%", ",", "70.3", "%", "and", "25.9", "%", "cases", "respectively", "."], "h": {"id": "C0022350", "name": "C0022350#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [12, 13]}}
{"token": ["C0068006#ent", "<e1>", "was", "the", "most", "active", "of", "the", "C1510852#ent", "<e2>", ",", "especially", "in", "the", "inhibition", "of", "the", "RNA", "synthesis"], "h": {"id": "C0068006", "name": "C0068006#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1510852", "name": "C1510852#ent", "pos": [8, 9]}}
{"token": ["At", "autopsy", ",", "C0015300#ent", "<e1>", ",", "prune", "belly", "sequence", "urethal", "atresia", "megacystis", ",", "tetralogy", "of", "C1418436#ent", "<e2>", ",", "atrioventricular", "canal", "defect", "and", "complete", "malrotation", "of", "the", "gut", "were", "identified", "."], "h": {"id": "C0015300", "name": "C0015300#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418436", "name": "C1418436#ent", "pos": [15, 16]}}
{"token": ["An", "initial", "subsensitivity", "to", "carbachol", "at", "30", "-", "100", "days", "of", "C0011849#ent", "<e1>", "subsequently", "converted", "to", "a", "supersensitivity", "to", "the", "C0003385#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0003385", "name": "C0003385#ent", "pos": [20, 21]}}
{"token": ["The", "C0815040#ent", "<e1>", ",", "bilobed", "protein", "calmodulin", "(", "C1537503#ent", "<e2>", ";", "molecular", "mass", "16.7", "kDa", ")", "can", "activate", "some", "40", "distinct", "proteins", "in", "a", "calcium-dependent", "manner", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1537503", "name": "C1537503#ent", "pos": [8, 9]}}
{"token": ["Using", "MBD2", "as", "bait", ",", "we", "isolated", "a", "novel", "C1421587#ent", "<e1>", "referred", "to", "as", "C1826255#ent", "<e2>", "."], "h": {"id": "C1421587", "name": "C1421587#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826255", "name": "C1826255#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "rats", "were", "treated", "with", "structurally", "related", "barbiturates", "C0030883#ent", "<e1>", ",", "amobarbital", ",", "barbital", ",", "and", "C0052970#ent", "<e2>"], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0052970", "name": "C0052970#ent", "pos": [18, 19]}}
{"token": ["Comparison", "of", "cDNA", "and", "protein", "sequences", "that", "at", "least", "four", "different", "C1540252#ent", "<e1>", "expressed", "in", "the", "C0340861#ent", "<e2>", "genome", "."], "h": {"id": "C1540252", "name": "C1540252#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0340861", "name": "C0340861#ent", "pos": [16, 17]}}
{"token": ["The", "unusually", "broad", "histologic", "spectrum", "C0264988#ent", "<e1>", "nodosa-like", "lesions", "in", "medium-sized", "vessels", "C2973529#ent", "<e2>", "small", "vessels", "as", "well", "as", "capillaritis", "."], "h": {"id": "C0264988", "name": "C0264988#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2973529", "name": "C2973529#ent", "pos": [12, 13]}}
{"token": ["Superior", "mesenteric", "arteriography", "C0333101#ent", "<e1>", "in", "jejunal", "branches", "with", "C0553548#ent", "<e2>", "small", "and", "medium", "sized", "muscular", "arteries", "the", "jejunum", "."], "h": {"id": "C0333101", "name": "C0333101#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0553548", "name": "C0553548#ent", "pos": [9, 10]}}
{"token": ["All", "of", "these", "compounds", "are", "unique", "from", "the", "classical", "C0265326#ent", "<e1>", "in", "that", "each", "has", "a", "reduced", "propensity", "to", "produce", "the", "C0020592#ent", "<e2>", "and/or", "muscle", "relaxant", "effects", "characteristically", "associated", "with", "C0265326#ent", "<e1>", "."], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0265326", "name": "C0265326#ent", "pos": [9, 10]}}
{"token": ["From", "the", "human", "PBMCs", "treated", "with", "C2983762#ent", "<e1>", ",", "TNF-alpha", "was", "a", "first", "C1333196#ent", "<e2>", "to", "be", "activated", ",", "detectable", "at", "2", "hr", "post-treatment", "followed", "by", "IL-1beta", "at", "6", "hr", "post-treatment", "."], "h": {"id": "C2983762", "name": "C2983762#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [13, 14]}}
{"token": ["Reference", "is", "made", "to", "studies", "carried", "out", "by", "the", "World", "Organization", "of", "Gastroenterology", "involving", "1,500", "patients", "with", "C0010346#ent", "<e1>", "6,000", "patients", "with", "C0000737#ent", "<e2>", "and", "1,300", "patients", "with", "upper", "GI", "bleeding"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [22, 23]}}
{"token": ["C3888090#ent", "<e1>", "a", "clinically", "and", "genetically", "heterogeneous", "group", "of", "C0026650#ent", "<e2>"], "h": {"id": "C3888090", "name": "C3888090#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [9, 10]}}
{"token": ["A", "double-blind", "study", "conducted", "to", "compare", "the", "efficacies", "of", "a", "C0003209#ent", "<e1>", "ketoprofen", ")", "and", "a", "central", "analgesic", "drug", "C0025376#ent", "<e2>", ")", "."], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025376", "name": "C0025376#ent", "pos": [19, 20]}}
{"token": ["To", "test", "the", "hypothesis", "that", "intracoronary", "infusion", "of", "pre-oxygenated", "C0383956#ent", "<e1>", "during", "brief", ",", "C0151814#ent", "<e2>", "preserve", "left", "ventricular", "function"], "h": {"id": "C0383956", "name": "C0383956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0151814", "name": "C0151814#ent", "pos": [14, 15]}}
{"token": ["Our", "data", "show", "that", "in", "C0919442#ent", "<e1>", "Ku70", "binds", "to", "C0812198#ent", "<e2>", "in", "an", "acetylation-sensitive", "manner", "."], "h": {"id": "C0919442", "name": "C0919442#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [10, 11]}}
{"token": ["Although", "several", "studies", "have", "been", "focused", "on", "the", "expression", "of", "C0085292#ent", "<e1>", ",", "little", "is", "known", "about", "C3273507#ent", "<e2>", "expression", "in", "glial", "cells", "neuropathological", "conditions"], "h": {"id": "C0085292", "name": "C0085292#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273507", "name": "C3273507#ent", "pos": [17, 18]}}
{"token": ["Studies", "suggested", "that", "insulin-", "or", "growth", "factor-induced", "4E-BP1", "phosphorylation", "is", "mediated", "by", "phosphatidylinositol", "3-kinase", "C2713509#ent", "<e1>", ")", "and", "its", "C1333246#ent", "<e2>", "Akt", "."], "h": {"id": "C2713509", "name": "C2713509#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1333246", "name": "C1333246#ent", "pos": [19, 20]}}
{"token": ["Ketoprofen", ",", "indomethacin", ",", "C0016377#ent", "<e1>", ",", "naproxen", "and", "acetylsalicylic", "acid", "reduced", "the", "release", "of", "C0058310#ent", "<e2>", "PGE", "from", "the", "isolated", "rabbit", "uterus", "."], "h": {"id": "C0016377", "name": "C0016377#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", ",", "we", "have", "demonstrated", "the", "dose-", "and", "time-dependent", "induction", "of", "DNA", "fragmentation", "by", "elevation", "of", "p53", "and", "C0249197#ent", "<e1>", "expression", "by", "C0950790#ent", "<e2>", "."], "h": {"id": "C0249197", "name": "C0249197#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0950790", "name": "C0950790#ent", "pos": [24, 25]}}
{"token": ["C0043153#ent", "<e1>", "sarcoplasmic", "reticulum", "vesicles", "contain", "a", "small", "amount", "of", "39-kDa", "CA", "IV-type", "C0027203#ent", "<e2>", "."], "h": {"id": "C0043153", "name": "C0043153#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}}
{"token": ["Other", "forms", "of", "renal", "disease", "lymphosarcoma", ",", "C1833683#ent", "<e1>", "acute", "and", "C0238304#ent", "<e2>", "and", "microabscessation", "related", "to", "septicaemia", "."], "h": {"id": "C1833683", "name": "C1833683#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0238304", "name": "C0238304#ent", "pos": [11, 12]}}
{"token": ["We", "compared", "the", "expression", "levels", "C2926735#ent", "<e1>", "of", "a", "model", "gene", "C1522405#ent", "<e2>", ",", "generated", "by", "the", "cellular", "promoters", "those", "by", "the", "cytomegalovirus", "(", "CMV", ")", "promoter", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [11, 12]}}
{"token": ["The", "excretion", "rates", "of", "the", "two", "urine", "proteins", "all", "enzymes", "except", "for", "C0017040#ent", "<e1>", "were", "the", "highest", "in", "patients", "suffering", "from", "C1442864#ent", "<e2>"], "h": {"id": "C0017040", "name": "C0017040#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [21, 22]}}
{"token": ["Increases", "in", "adipose", "C1706480#ent", "<e1>", "mRNA", "abundance", "in", "AT(2)R(-/-", ")", "mice", "were", "abolished", "by", "C0287041#ent", "<e2>", "."], "h": {"id": "C1706480", "name": "C1706480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0287041", "name": "C0287041#ent", "pos": [14, 15]}}
{"token": ["The", "plasma", "gamma-aminobutyric", "acid", "GABA", ")", "concentration", "was", "measured", "by", "a", "radio-receptor", "assay", "rat", "model", "of", "hepatic", "encephalopathy", "to", "C0162557#ent", "<e1>", "FHF", ")", "induced", "by", "intraperitoneal", "injection", "of", "D-galactosamine", "(", "C1414945#ent", "<e2>", ")", "."], "h": {"id": "C0162557", "name": "C0162557#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1414945", "name": "C1414945#ent", "pos": [30, 31]}}
{"token": ["We", "have", "investigated", "affected", "individuals", "from", "six", "pedigrees", ":", "five", "with", "C0678928#ent", "<e1>", "and", "one", "with", "C0678928#ent", "<e1>", "C0079588#ent", "<e1>", "XLI", ")", "."], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079588", "name": "C0079588#ent", "pos": [18, 19]}}
{"token": ["The", "combined", "application", "of", "C0040373#ent", "<e1>", "and", "Dopamine", "for", "the", "treatment", "of", "the", "persistent", "C0031190#ent", "<e2>", "that", "Dopamine", "prevented", "the", "most", "common", "side", "effects", "C0040373#ent", "<e1>", "i.e.", "systemic", "hypotension", "oliguria", "."], "h": {"id": "C0040373", "name": "C0040373#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0031190", "name": "C0031190#ent", "pos": [14, 15]}}
{"token": ["C1436155#ent", "<e1>", "ASK1", ")", "is", "a", "C1367798#ent", "<e2>", "plays", "an", "important", "role", "in", "stress-induced", "apoptosis"], "h": {"id": "C1436155", "name": "C1436155#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367798", "name": "C1367798#ent", "pos": [6, 7]}}
{"token": ["C0019825#ent", "<e1>", "ORF", "is", "predicted", "to", "encode", "an", "C0815040#ent", "<e2>", ",", "arginine", "residue", "rich", "."], "h": {"id": "C0019825", "name": "C0019825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [8, 9]}}
{"token": ["We", "describe", "a", "63-year-old", "patient", "in", "whom", "CNS", "involvement", "with", "C0023788#ent", "<e1>", "the", "clinical", "and", "imaging", "features", "of", "a", "C0521542#ent", "<e2>"], "h": {"id": "C0023788", "name": "C0023788#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0521542", "name": "C0521542#ent", "pos": [19, 20]}}
{"token": ["Modulation", "of", "resistance", "was", "observed", "with", "C0044667#ent", "<e1>", "0.2", "microM", "for", "1", "h", ")", "prior", "to", "C0079083#ent", "<e2>", "."], "h": {"id": "C0044667", "name": "C0044667#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079083", "name": "C0079083#ent", "pos": [16, 17]}}
{"token": ["Progress", "in", "understanding", "basic", "immune", "mechanisms", "C0268731#ent", "<e1>", "outlined", ",", "including", "the", "roles", "of", "chemoattractants", ",", "adhesion", "molecules", "C0025543#ent", "<e2>", ",", "and", "cytokines", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025543", "name": "C0025543#ent", "pos": [18, 19]}}
{"token": ["Balloon", "cells", "large", "dysplastic", "neurons", "in", "all", "specimens", "expressed", "Otx1", ",", "phospho-vimentin", ",", "C1418276#ent", "<e1>", "and", "BLBP", ",", "C0086376#ent", "<e2>", "normally", "expressed", "by", "cells", "in", "the", "embryonic", "ventricular", "zone", "."], "h": {"id": "C1418276", "name": "C1418276#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [18, 19]}}
{"token": ["Patients", "who", "received", "the", "combination", "of", "C0027556#ent", "<e1>", "and", "C0700583#ent", "<e2>", "required", "significantly", "less", "morphine", "than", "those", "who", "received", "C0027556#ent", "<e1>", "alone", "(", "p", "less", "than", "0.01", ")", "."], "h": {"id": "C0700583", "name": "C0700583#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027556", "name": "C0027556#ent", "pos": [6, 7]}}
{"token": ["We", "describe", "a", "case", "of", "persistent", "C0427055#ent", "<e1>", "in", "a", "31-year-old", "woman", "with", "C0026896#ent", "<e2>", "therapeutic", "electric", "stimulation", "."], "h": {"id": "C0427055", "name": "C0427055#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [13, 14]}}
{"token": ["It", "is", "suggested", "that", "C0175697#ent", "<e1>", "causes", "alterations", "in", "intracellular", "C3653518#ent", "<e2>", "perturbations", "in", "the", "calcium-dependent", "signal", "transduction", "pathway"], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3653518", "name": "C3653518#ent", "pos": [10, 11]}}
{"token": ["Dose-response", "curves", "to", "ET-1", "were", "determined", ",", "and", "the", "vasoactive", "properties", "of", "E(2)", "propylpyrazole", "triol", "PPT", ",", "ER-alpha", "C2987634#ent", "<e1>", ")", ",", "and", "diarylpropionitrile", "(", "DPN", ",", "C1414462#ent", "<e2>", "were", "determined", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414462", "name": "C1414462#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", ",", "DPCPX", "increased", "C1366535#ent", "<e1>", "IscCl", ",", "an", "effect", "that", "was", "reversed", "by", "C1420648#ent", "<e2>", "."], "h": {"id": "C1366535", "name": "C1366535#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420648", "name": "C1420648#ent", "pos": [15, 16]}}
{"token": ["C0147003#ent", "<e1>", "a", "free", "radical", "scavenger", "prevented", "most", "of", "this", "C4283796#ent", "<e2>", "increase", "."], "h": {"id": "C0147003", "name": "C0147003#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4283796", "name": "C4283796#ent", "pos": [10, 11]}}
{"token": ["Diffuse", "alveolar", "deposits", "of", "C1161320#ent", "<e1>", "been", "identified", "in", "the", "lungs", "of", "two", "C0032950#ent", "<e2>", "beagles", "with", "chronic", "S", "stercoralis", "infection", "."], "h": {"id": "C1161320", "name": "C1161320#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [13, 14]}}
{"token": ["C0019587#ent", "<e1>", "SSAO", ")", "is", "located", "in", "the", "C1412137#ent", "<e2>", "retina", ",", "kidney", "and", "the", "cartilage", "tissues", "and", "it", "circulates", "in", "the", "blood", "."], "h": {"id": "C0019587", "name": "C0019587#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412137", "name": "C1412137#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "demonstrate", "that", "two", "C0907533#ent", "<e1>", "activating", "mutations", "occurring", "in", "distant", "receptor", "domains", "of", "the", "C1865268#ent", "<e2>", "divergent", "effects", "on", "the", "regulatory", "properties", "the", "receptor", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1865268", "name": "C1865268#ent", "pos": [16, 17]}}
{"token": ["C0242350#ent", "<e1>", "in", "diabetic", "men", "is", "associated", "with", "C0475718#ent", "<e2>", ",", "stress", "and", "definite", "autonomic", "neuropathy"], "h": {"id": "C0242350", "name": "C0242350#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0475718", "name": "C0475718#ent", "pos": [8, 9]}}
{"token": ["Intrathecal", "acetylsalicylic", "acid", "C0021246#ent", "<e1>", "are", "analgesic", "for", "C0030193#ent", "<e2>", "stimuli", ",", "and", "this", "has", "been", "demonstrated", "when", "the", "noxious", "stimuli", "are", "applied", "to", "normal", "and", "inflamed", "tissue", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [8, 9]}}
{"token": ["Severe", "systemic", "hypertension", "in", "a", "patient", "who", "took", "C0021246#ent", "<e1>", "shortly", "after", "ingesting", "an", "C0003620#ent", "<e2>", "'", "Trimolets", "'", ")", "containing", "phenylpropanolamine", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [14, 15]}}
{"token": ["Two", "C1861833#ent", "<e1>", "genes", "within", "the", "direct", "repeat", "C0341703#ent", "<e2>", "3", ",", "expressed", "IE", "transcripts", "."], "h": {"id": "C1861833", "name": "C1861833#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0341703", "name": "C0341703#ent", "pos": [8, 9]}}
{"token": ["Overall", ",", "the", "results", "presented", "in", "this", "paper", "provided", "strong", "evidence", "that", "the", "proteins", "VP5", "and", "VP7", "of", "C1706012#ent", "<e1>", "play", "an", "indispensable", "role", "in", "C0042769#ent", "<e2>"], "h": {"id": "C1706012", "name": "C1706012#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [25, 26]}}
{"token": ["Using", "mass", "spectrometry", "NMR", "spectroscopy", "and", "fluorescence", "experiments", "have", "demonstrated", "that", "compound", "1", "binds", "reversibly", "to", "the", "C1412058#ent", "<e1>", "the", "24", "kDa", "N-terminal", "fragment", "C0120543#ent", "<e2>", "Escherichia", "coli", "GyrB24", ")", "with", "low", "micromolar", "affinity", "."], "h": {"id": "C1412058", "name": "C1412058#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0120543", "name": "C0120543#ent", "pos": [24, 25]}}
{"token": ["C0032910#ent", "<e1>", "also", "modified", "the", "concentration-response", "curves", "C1414518#ent", "<e2>", "in", "calcium-free", "and", "high", "K/", "medium", "as", "soon", "as", "concentration-response", "curves", "acetylcholine", "in", "Tyrode", "solution", "."], "h": {"id": "C0032910", "name": "C0032910#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414518", "name": "C1414518#ent", "pos": [7, 8]}}
{"token": ["The", "pmsB", "gene", "induced", "low", "levels", "of", "C1825840#ent", "<e1>", "production", "in", "E.", "coli", "expressed", "under", "control", "of", "the", "C3889703#ent", "<e2>", "promoter", "."], "h": {"id": "C1825840", "name": "C1825840#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3889703", "name": "C3889703#ent", "pos": [18, 19]}}
{"token": ["The", "alcohol", "sensitivity", "delta-containing", "receptors", "underlie", "the", "reinforcing", "effects", "of", "C0001962#ent", "<e1>", "during", "C1868117#ent", "<e2>", ",", "when", "eye", "saccade", "responses", "to", "low", "doses", "C0001962#ent", "<e1>", "are", "increased", "."], "h": {"id": "C1868117", "name": "C1868117#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [10, 11]}}
{"token": ["The", "modulation", "of", "spontaneous", "release", "of", "acetylcholine", "by", "specific", "Ca2", "+", "C0870261#ent", "<e1>", "studied", "at", "neonatal", "rat", "C0751950#ent", "<e2>"], "h": {"id": "C0870261", "name": "C0870261#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [17, 18]}}
{"token": ["Mutagenesis", "of", "threonine", "391", "to", "alanine", "significantly", "impaired", "14", "-", "3", "-", "3", "binding", "to", "the", "C1706337#ent", "<e1>", "in", "both", "C0017837#ent", "<e2>", "coimmunoprecipitation", "assays"], "h": {"id": "C1706337", "name": "C1706337#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [20, 21]}}
{"token": ["The", "inactivating", "enzyme", "contributing", "to", "C0796126#ent", "<e1>", "resistance", "was", "AAC", "for", "almost", "Gram-negative", "bacillis", "C1332101#ent", "<e2>", "+", "AAC", "for", "S.", "aureus"], "h": {"id": "C0796126", "name": "C0796126#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332101", "name": "C1332101#ent", "pos": [14, 15]}}
{"token": ["Direct", "comparison", "to", "maladaptive", "hypertrophy", "enabled", "by", "quantitative", "PCR", "key", "metabolic", "C0014442#ent", "<e1>", "including", "uncoupling", "protein", "2", "UCP2", ")", "and", "C1366645#ent", "<e2>", "CD36", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1366645", "name": "C1366645#ent", "pos": [20, 21]}}
{"token": ["Contrasting", "with", "other", "GAPs", ",", "OCRL1", "C1412520#ent", "<e1>", "exhibited", "a", "significant", "interaction", "with", "GDP", "bound", "C0285558#ent", "<e2>", "in", "vitro"], "h": {"id": "C1412520", "name": "C1412520#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [15, 16]}}
{"token": ["Two", "antibodies", "were", "prepared", "for", "use", "in", "a", "sandwich", "enzyme", "immunoassay", "human", "IgG.", "Completely", "purified", "guinea", "pig", "anti-human", "IgG", "labelled", "with", "C0005220#ent", "<e1>", "(", "EC", "3.2.1.23", ",", "using", "a", "heterobifunctional", "cross-linker", "named", "C0067581#ent", "<e2>", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0067581", "name": "C0067581#ent", "pos": [32, 33]}}
{"token": ["Rheumatoid", "arthritis", "RA", ")", "is", "a", "chronic", ",", "autoimmune", "disease", "has", "traditionally", "been", "treated", "with", "C4054347#ent", "<e1>", "and", "biologic", "disease-modifying", "antirheumatic", "drugs", "C0242708#ent", "<e2>", ")", "."], "h": {"id": "C4054347", "name": "C4054347#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0242708", "name": "C0242708#ent", "pos": [22, 23]}}
{"token": ["Bronchoconstrictor", "responses", "C0914069#ent", "<e1>", "PAF", ")", "were", "blocked", "by", "SK&F", "95587", "by", "the", "novel", "C0019593#ent", "<e2>", "BN", "50730", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [14, 15]}}
{"token": ["Olfactory", "neuropathy", "which", "rarely", "occurred", "in", "typical", "C0235025#ent", "<e1>", "could", "be", "a", "special", "type", "of", "neuropathy", "induced", "by", "C0042769#ent", "<e2>", "SARS", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [18, 19]}}
{"token": ["BAL", "cells", "14", "patients", "with", "different", "C0034087#ent", "<e1>", "stained", "with", "C1706001#ent", "<e2>", "and", "anti-CD120b", "monoclonal", "antibodies", "were", "differentiated", "by", "FACS", "analysis", "."], "h": {"id": "C0034087", "name": "C0034087#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706001", "name": "C1706001#ent", "pos": [10, 11]}}
{"token": ["These", "C0796126#ent", "<e1>", "are", "encoded", "by", "the", "C0079941#ent", "<e2>", "the", "3", "'", "long", "terminal", "repeat", "MMTV", ",", "termed", "MMTV", "C0796126#ent", "<e1>", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0796126", "name": "C0796126#ent", "pos": [1, 2]}}
{"token": ["A", "comprehensive", ",", "practical", "review", "of", "the", "short-", "and", "long-term", "therapy", "for", "patients", "with", "C0011848#ent", "<e1>", "including", "central", "diabetes", "insipidus", "nephrogenic", "diabetes", "insipidus", "and", "the", "\"", "excessive", "C0687720#ent", "<e2>", "\"", "is", "presented", "."], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [14, 15]}, "relation": "nichd_parent_of", "t": {"id": "C0687720", "name": "C0687720#ent", "pos": [27, 28]}}
{"token": ["Western", "blot", "analysis", "that", "HOXB13", "down-regulates", "the", "expression", "of", "C3811072#ent", "<e1>", "and", "its", "responsive", "genes", ",", "C0079068#ent", "<e2>", "and", "cyclin", "D1"], "h": {"id": "C3811072", "name": "C3811072#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [16, 17]}}
{"token": ["On", "the", "other", "hand", ",", "piribedil", ",", "C0002403#ent", "<e1>", ",", "imipramine", "or", "C0011685#ent", "<e2>", "treatment", "failed", "to", "reverse", "the", "reserpine-induced", "hyperalgesia", "."], "h": {"id": "C0002403", "name": "C0002403#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [12, 13]}}
{"token": ["C0950430#ent", "<e1>", ",", "a", "member", "of", "a", "family", "of", "microbial", "C0018364#ent", "<e2>", "catalyzes", "the", "endonucleotic", "cleavage", "of", "single-stranded", "RNA"], "h": {"id": "C0950430", "name": "C0950430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018364", "name": "C0018364#ent", "pos": [10, 11]}}
{"token": ["A", "case", "of", "C1835677#ent", "<e1>", "in", "a", "patient", "with", "probable", "C0268338#ent", "<e2>", "described", "."], "h": {"id": "C1835677", "name": "C1835677#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268338", "name": "C0268338#ent", "pos": [10, 11]}}
{"token": ["Structure", "of", "C0035204#ent", "<e1>", "represented", "mainly", "by", "C0003165#ent", "<e2>", "by", "toxic", "and", "dust", "factors", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003165", "name": "C0003165#ent", "pos": [7, 8]}}
{"token": ["LEOPARD", "is", "an", "acronym", "for", "the", "major", "features", "of", "this", "disorder", ",", "including", "multiple", "Lentigines", "ECG", "conduction", "abnormalities", ",", "Ocular", "hypertelorism", "C1956257#ent", "<e1>", "Abnormal", "genitalia", ",", "Retardation", "of", "growth", "and", "C0452138#ent", "<e2>"], "h": {"id": "C1956257", "name": "C1956257#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0452138", "name": "C0452138#ent", "pos": [30, 31]}}
{"token": ["In", "the", "work", "reported", "here", "we", "have", "shown", "that", "C0238239#ent", "<e1>", "Fd", "fragments", "be", "separated", "completely", "in", "C0072186#ent", "<e2>", "then", "recombined", "to", "form", "Fab", "fragments", "antibody", "activity"], "h": {"id": "C0238239", "name": "C0238239#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0072186", "name": "C0072186#ent", "pos": [17, 18]}}
{"token": ["We", "managed", "four", "patients", "with", "C0553730#ent", "<e1>", "and", "hypomagnesemia", "who", "met", "criteria", "for", "C0268450#ent", "<e2>", "including", "hypomagnesemia", ",", "hypokalemia", "with", "normal", "or", "high", "urinary", "potassium", "excretion", ",", "hypocalciuria", ",", "and", "normal", "blood", "pressure"], "h": {"id": "C0553730", "name": "C0553730#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0268450", "name": "C0268450#ent", "pos": [13, 14]}}
{"token": ["Blocking", "antibodies", "integrin", "beta1", "C1332712#ent", "<e1>", ",", "or", "CD9", "affected", "neither", "the", "C1417154#ent", "<e2>", "PaCa-2", "binding", "to", "HUVEC", "nor", "the", "reduction", "of", "TEER", "."], "h": {"id": "C1332712", "name": "C1332712#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417154", "name": "C1417154#ent", "pos": [12, 13]}}
{"token": ["C0380051#ent", "<e1>", "a", "key", "C0027203#ent", "<e2>", "mediating", "the", "cellular", "response", "a", "variety", "of", "extracellular", "stimuli", "."], "h": {"id": "C0380051", "name": "C0380051#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [4, 5]}}
{"token": ["The", "C0079429#ent", "<e1>", "does", "not", "increase", "the", "activity", "of", "C1510851#ent", "<e2>", "in", "the", "cell", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1510851", "name": "C1510851#ent", "pos": [9, 10]}}
{"token": ["The", "ratio", "of", "C1706005#ent", "<e1>", ",", "IgG", "and", "IgA", "PFC", "was", "unaffected", "by", "C0004057#ent", "<e2>", "and", "ST", "."], "h": {"id": "C1706005", "name": "C1706005#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [13, 14]}}
{"token": ["C0043116#ent", "<e1>", "the", "most", "severe", "and", "mortality", "is", "usually", "due", "to", "C1145670#ent", "<e2>"], "h": {"id": "C0043116", "name": "C0043116#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C1145670", "name": "C1145670#ent", "pos": [11, 12]}}
{"token": ["Headache", ",", "breast", "pain", "C2364135#ent", "<e1>", ",", "abdominal", "pain", "C2364135#ent", "<e1>", ",", "uterine", "bleeding", "dysmenorrhoea", ",", "C0013604#ent", "<e1>", ",", "nausea", "and", "depression", "were", "the", "most", "commonly", "reported", "adverse", "events"], "h": {"id": "C2364135", "name": "C2364135#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013604", "name": "C0013604#ent", "pos": [16, 17]}}
{"token": ["The", "intravenous", "glucagon", "tolerance", "test", "not", "discriminate", "between", "phosphorylase", "kinase", "deficiency", "C0017920#ent", "<e1>", "GSD", ")", "IX", "]", "and", "phosphorylase", "deficiency", "C0017925#ent", "<e2>", "."], "h": {"id": "C0017920", "name": "C0017920#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017925", "name": "C0017925#ent", "pos": [20, 21]}}
{"token": ["Inherited", "deficiencies", "of", "the", "enzymes", "adenosine", "deaminase", "C0164674#ent", "<e1>", "EC", "3.5.4.4", ")", "and", "purine", "nucleoside", "phosphorylase", "purine-nucleoside", ":", "C0002492#ent", "<e2>", "EC", "2.4.2.1", "preferentially", "interfere", "with", "lymphocyte", "development", "while", "sparing", "most", "other", "organ", "systems"], "h": {"id": "C0164674", "name": "C0164674#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002492", "name": "C0002492#ent", "pos": [18, 19]}}
{"token": ["The", "C0029896#ent", "<e1>", "include", "the", "theilerioses", ",", "brown", "tick", "toxicosis", "and", "C0027345#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0027345", "name": "C0027345#ent", "pos": [11, 12]}}
{"token": ["increased", "MAP", "and", "decreased", "HR", ",", "effects", "that", "were", "antagonized", "by", "carbidopa", "and", "C0032912#ent", "<e1>", "but", "not", "by", "C0011685#ent", "<e2>", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011685", "name": "C0011685#ent", "pos": [18, 19]}}
{"token": ["We", "describe", "the", "case", "of", "an", "acromegalic", "woman", "with", "C0553573#ent", "<e1>", "was", "treated", "with", "clomiphene", ",", "and", "subsequently", "developed", "C0038454#ent", "<e2>"], "h": {"id": "C0553573", "name": "C0553573#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [19, 20]}}
{"token": ["Several", "C0019247#ent", "<e1>", "immunodeficiency", "(", "ID", ")", "syndromes", "or", "C0012634#ent", "<e2>", "Ataxia", "Telangiectasia", "AT", ")", ",", "and", "Nijmegen", "breakage", "syndrome", "NBS", ")", "were", "associated", "with", "elevated", "risk", "for", "severe", "treatment", "related", "toxicity", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [9, 10]}}
{"token": ["The", "amino", "acid", "sequence", "PHBP", "is", "C1512488#ent", "<e1>", "to", "that", "of", "C1415534#ent", "<e2>"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415534", "name": "C1415534#ent", "pos": [11, 12]}}
{"token": ["The", "proportion", "of", "T-cell", "subsets", "normal", "in", "all", "patients", "with", "C0221026#ent", "<e1>", "for", "an", "8-month", "patient", "who", "showed", "a", "decrease", "in", "C1413244#ent", "<e2>", "population", "."], "h": {"id": "C0221026", "name": "C0221026#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413244", "name": "C1413244#ent", "pos": [21, 22]}}
{"token": ["The", "motor-evoked", "potential", "amplitude", "in", "the", "right", "abductor", "pollicis", "brevis", "muscle", "increased", "by", "C1423757#ent", "<e1>", "in", "healthy", "volunteers", "but", "not", "in", "C3160718#ent", "<e2>", "patients", "."], "h": {"id": "C1423757", "name": "C1423757#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3160718", "name": "C3160718#ent", "pos": [21, 22]}}
{"token": ["In", "humans", ",", "it", "is", "linked", "to", "several", "C0009450#ent", "<e1>", "including", "leprosy", ",", "pulmonary", "tuberculosis", "C0023290#ent", "<e2>", "meningococcal", "meningitis", "and", "human", "immunodeficiency", "virus", "well", "as", "to", "autoimmune", "diseases", "as", "rheumatoid", "arthritis", "Crohn's", "disease"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [15, 16]}}
{"token": ["However", ",", "inclusion", "bodies", "abnormal", "glycogen", "accumulate", "in", "several", "C0027765#ent", "<e1>", "particularly", "in", "progressive", "myoclonus", "epilepsy", "C0751783#ent", "<e2>"], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0751783", "name": "C0751783#ent", "pos": [16, 17]}}
{"token": ["C0282625#ent", "<e1>", "Fyn", ",", "Lyn", ",", "and", "Lck", "associate", "with", "C1705969#ent", "<e2>", "and", "phosphorylate", "both", "Y-165", "and", "Y-182", "that", "are", "mainly", "responsible", "for", "interaction", "with", "Fyn", "through", "its", "SH2", "domain"], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [10, 11]}}
{"token": ["Normal", "human", "lung", "parenchyma", "passively", "sensitized", "with", "an", "C1366263#ent", "<e1>", "releases", "eicosanoids", "from", "the", "cyclo-oxygenase", "pathway", "from", "different", "C0023837#ent", "<e2>", "(", "5-", ",", "12-", ",", "15-HETE", ")", "upon", "anti-IgE", "challenge", "."], "h": {"id": "C1366263", "name": "C1366263#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [18, 19]}}
{"token": ["Gender", ",", "coexisting", "hypercholesterolaemia", ",", "arterial", "hypertension", "C0011849#ent", "<e1>", "had", "no", "impact", "on", "concentrations", "of", "C0030350#ent", "<e2>", "and", "D-dimers", "in", "blood", "of", "patients", "suffering", "from", "acute", "coronary", "syndrome", "ST", "segment", "elevation", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030350", "name": "C0030350#ent", "pos": [15, 16]}}
{"token": ["The", "subcellular", "distribution", "of", "carnitine", "acetyl-", "octanoyl-", ",", "and", "C0074375#ent", "<e1>", "the", "livers", "of", "normal", "and", "C0009002#ent", "<e2>", "male", "rats", "was", "studied", "with", "isopycnic", "sucrose", "density", "gradient", "fractionation", "."], "h": {"id": "C0074375", "name": "C0074375#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [16, 17]}}
{"token": ["New", "cytotoxic", "therapies", "including", "the", "C3541958#ent", "<e1>", ",", "gemcitabine", "(", "Gemzar", ")", ",", "vinorelbine", "(", "C0131965#ent", "<e2>", ")", "and", "irinotecan", "(", "Campto", ")", ",", "have", "improved", "treatment", "outcome", "expanded", "treatment", "options", "in", "advanced", "non-small", "cell", "lung", "cancer"], "h": {"id": "C3541958", "name": "C3541958#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0131965", "name": "C0131965#ent", "pos": [15, 16]}}
{"token": ["In", "healthy", "human", "volunteers", ",", "the", "psychotomimetic", "effects", "psilocybin", "were", "blocked", "dose-dependently", "by", "the", "serotonin-2A", "antagonist", "C0022616#ent", "<e1>", "or", "the", "atypical", "C0040615#ent", "<e2>", "but", "were", "increased", "by", "the", "dopamine", "antagonist", "typical", "antipsychotic", "haloperidol"], "h": {"id": "C0022616", "name": "C0022616#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0040615", "name": "C0040615#ent", "pos": [21, 22]}}
{"token": ["Results", "indicate", "that", "C0044729#ent", "<e1>", "by", "contrast", "with", "C0008932#ent", "<e2>", ")", "is", "not", "efficiently", "retained", "on", "the", "CN", ",", "SCX", ",", "and", "MPH", "SPE", "columns", "recovery", "<", "10", "%", ")", "."], "h": {"id": "C0044729", "name": "C0044729#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008932", "name": "C0008932#ent", "pos": [8, 9]}}
{"token": ["The", "HLA", "DQA1", "DQB1", "high-risk", "genotypes", "associated", "with", "C0007570#ent", "<e1>", "similar", "in", "these", "Bedouin", "families", "with", "C1705969#ent", "<e2>", "to", "what", "is", "observed", "in", "Northern", "and", "Southern", "Europeans", "."], "h": {"id": "C0007570", "name": "C0007570#ent", "pos": [8, 9]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [16, 17]}}
{"token": ["Also", "analyzed", "were", "the", "same", "parameters", "in", "99", "C0011860#ent", "<e1>", "patients", "before", "and", "after", "therapy", "with", "Acarbose", "or", "C0061323#ent", "<e2>", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0061323", "name": "C0061323#ent", "pos": [18, 19]}}
{"token": ["We", "propose", "that", "the", "absence", "of", "C0919524#ent", "<e1>", "modifies", "the", "organization", "of", "the", "telomeres", ",", "which", "allows", "C3889407#ent", "<e2>", "and", "Reb1", "to", "cis-inhibit", "telomerase"], "h": {"id": "C0919524", "name": "C0919524#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3889407", "name": "C3889407#ent", "pos": [17, 18]}}
{"token": ["Aging", "was", "also", "associated", "with", "marked", "increase", "in", "the", "activity", "of", "the", "degradation", "enzymes", "AMP", "deaminase", "C0034135#ent", "<e1>", "PNP", ")", "and", "guanine", "deaminase", "C1415029#ent", "<e2>", ")", "."], "h": {"id": "C0034135", "name": "C0034135#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1415029", "name": "C1415029#ent", "pos": [23, 24]}}
{"token": ["Overexpression", "of", "cyclooxygenase-2", "and", "C4082991#ent", "<e1>", "in", "tumors", "and", "contributes", "to", "increased", "C1868501#ent", "<e2>", "synthesis", "."], "h": {"id": "C4082991", "name": "C4082991#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1868501", "name": "C1868501#ent", "pos": [12, 13]}}
{"token": ["C1865322#ent", "<e1>", "FHM-2", ")", "and", "common", "types", "of", "C0149931#ent", "<e2>", "show", "phenotypic", "similarities", "which", "may", "indicate", "a", "common", "neurobiological", "background"], "h": {"id": "C1865322", "name": "C1865322#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [8, 9]}}
{"token": ["This", "suggests", "that", "some", "variant", "of", "the", "triple", "A", "Syndrome", "C1321756#ent", "<e1>", ",", "alacrima", ",", "and", "C0405580#ent", "<e2>", "may", "exist", "in", "adult", "patients", "with", "C1321756#ent", "<e1>", "as", "well", "."], "h": {"id": "C0405580", "name": "C0405580#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1321756", "name": "C1321756#ent", "pos": [10, 11]}}
{"token": ["We", "observed", "that", "monomeric", "human", "C3536873#ent", "<e1>", "IgG", ")", "sensitizes", "these", "cells", "to", "the", "chemotactic", "peptide", "N-formylmethionylleucylphenylalanine", "C1705725#ent", "<e2>", ")", "."], "h": {"id": "C3536873", "name": "C3536873#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [17, 18]}}
{"token": ["Three", "candidate", "C0079427#ent", "<e1>", "been", "identified", "in", "it", ":", "DCC", ",", "Smad4/DPC4", "and", "C1566790#ent", "<e2>", ";", "the", "mechanisms", "involving", "their", "inactivation", "have", "not", "been", "completely", "elucidated", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1566790", "name": "C1566790#ent", "pos": [13, 14]}}
{"token": ["Deletion", "or", "substitution", "within", "the", "C-terminal", "domain", "C1705526#ent", "<e1>", "can", "also", "compromise", "its", "ability", "to", "repress", "C0012890#ent", "<e2>", "in", "vitro", "in", "transfected", "cells", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0012890", "name": "C0012890#ent", "pos": [16, 17]}}
{"token": ["C0030920#ent", "<e1>", "been", "shown", "to", "be", "an", "extremely", "important", "C0003438#ent", "<e2>", "in", "HIV", "transmission", "."], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [9, 10]}}
{"token": ["By", "freeze-fracture", "replica", "immunogold", "labeling", ",", "C1846885#ent", "<e1>", "was", "found", "in", "ultrastructurally-defined", "neuronal", "gap", "junctions", "whereas", "C1415076#ent", "<e2>", "and", "Cx26", "were", "not", "detected", "in", "neurons", "and", "only", "rarely", "detected", "in", "glia", "."], "h": {"id": "C1846885", "name": "C1846885#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415076", "name": "C1415076#ent", "pos": [16, 17]}}
{"token": ["The", "hydrolase", "and", "C0023689#ent", "<e1>", "remarkable", "similarities", "to", "the", "catalytic", "domains", "the", "cyclic", "phosphodiesterase", "C0028632#ent", "<e2>", "respectively", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028632", "name": "C0028632#ent", "pos": [14, 15]}}
{"token": ["Glucuronidation", "is", "often", "considered", "to", "be", "affected", "to", "a", "lesser", "extent", "than", "CYP450-mediated", "reactions", "in", "mild", "to", "moderate", "C1623038#ent", "<e1>", "but", "can", "also", "be", "substantially", "impaired", "in", "patients", "with", "C1263666#ent", "<e2>"], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1263666", "name": "C1263666#ent", "pos": [29, 30]}}
{"token": ["We", "demonstrate", "that", "cooperation", "between", "C1824738#ent", "<e1>", "and", "CBP", "is", "independent", "of", "CBP", "C1540026#ent", "<e2>", "activity", "."], "h": {"id": "C1824738", "name": "C1824738#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1540026", "name": "C1540026#ent", "pos": [13, 14]}}
{"token": ["Prolonged", "administration", "of", "transgalacto-oligosaccharides", ",", "at", "a", "dose", "which", "does", "not", "induce", "C1457887#ent", "<e1>", "increases", "the", "number", "of", "bifidobacteria", "and", "C2712370#ent", "<e2>", "the", "fermentative", "activity", "of", "colonic", "flora", "humans", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [20, 21]}}
{"token": ["The", "interaction", "of", "C2983693#ent", "<e1>", "and", "deltaENaC", "was", "confirmed", "by", "C0017837#ent", "<e2>", "coimmunoprecipitation", "."], "h": {"id": "C2983693", "name": "C2983693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [10, 11]}}
{"token": ["Corticotrophic", "signaling", "by", "LIF", "is", "thus", "subject", "to", "2", "forms", "of", "negative", "autoregulation", ":", "dephosphorylation", "of", "C1334291#ent", "<e1>", "and", "STAT3", "by", "the", "C1384543#ent", "<e2>", "and", "SOCS-3-dependent", "inactivation", "of", "C1334291#ent", "<e1>", "."], "h": {"id": "C1334291", "name": "C1334291#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1384543", "name": "C1384543#ent", "pos": [22, 23]}}
{"token": ["Here", ",", "the", "history", "of", "how", "the", "XPG", "gene", "discovered", ",", "the", "biochemical", "properties", "of", "the", "C1705470#ent", "<e1>", "the", "molecular", "defects", "in", "C0268141#ent", "<e2>", "patients", "and", "mouse", "models", "reviewed", "."], "h": {"id": "C1705470", "name": "C1705470#ent", "pos": [16, 17]}, "relation": "gene_associated_with_disease", "t": {"id": "C0268141", "name": "C0268141#ent", "pos": [22, 23]}}
{"token": ["In", "this", "article", ",", "the", "author", "reviews", "of", "the", "most", "common", "C0042384#ent", "<e1>", "including", ":", "polyarteritis", "nodosa", "Churg-Strauss", "syndrome", "Wegener's", "granulomatosis", "hypersensitivity", "vasculitis", "Henoch-Schonlein", "purpura", "giant", "cell", "arteritis", "and", "C0039263#ent", "<e2>"], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [11, 12]}, "relation": "nichd_parent_of", "t": {"id": "C0039263", "name": "C0039263#ent", "pos": [29, 30]}}
{"token": ["This", "study", "examines", "the", "effects", "of", "sodium", "homeostasis", "circadian", "rhythm", "C0000172#ent", "<e1>", "18-OHB", ")", "responses", "to", "the", "C0178601#ent", "<e2>", "metoclopramide", "in", "seven", "normal", "individuals", "."], "h": {"id": "C0000172", "name": "C0000172#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0178601", "name": "C0178601#ent", "pos": [17, 18]}}
{"token": ["Interestingly", ",", "a", "lower", "dose", "C0175697#ent", "<e1>", "(", "1", "ng/kg", ")", "induced", "C0175697#ent", "<e1>", "tolerance", "accompanied", "with", "C1334136#ent", "<e1>", "up-regulation", "but", "without", "depletion", "of", "IRAK-1", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334136", "name": "C1334136#ent", "pos": [17, 18]}}
{"token": ["In", "conclusion", ",", "for", "the", "first", "time", "it", "is", "reported", "that", "the", "binding", "of", "a", "small", "synthetic", "fragment", "sufficient", "to", "promote", "efficient", "capping", "by", "C0879262#ent", "<e1>", "at", "the", "C0687751#ent", "<e2>", "end", "of", "actin", "filaments"], "h": {"id": "C0879262", "name": "C0879262#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0687751", "name": "C0687751#ent", "pos": [28, 29]}}
{"token": ["Strong", "anti-PACAP", "immunoreactivity", "was", "found", "in", "the", "pituitary", "pars", "nervosa", "PN", ")", ",", "suggesting", "that", "this", "neurohemal", "organ", "a", "source", "of", "neurohormonal", "C1412228#ent", "<e1>", "action", "on", "the", "C1337111#ent", "<e2>", "in", "the", "intermediate", "pituitary"], "h": {"id": "C1412228", "name": "C1412228#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1337111", "name": "C1337111#ent", "pos": [27, 28]}}
{"token": ["C0879590#ent", "<e1>", "was", "most", "successfully", "induced", "with", "a", "high", "dose", "the", "C0022022#ent", "<e2>", "A23187", "combined", "with", "phorbol", "12-myristate", "13-acetate", "PMA", ")", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [11, 12]}}
{"token": ["Analysis", "of", "the", "functional", "responsiveness", "of", "the", "three", "distinct", "groups", "of", "JA3", "cell", "variants", "to", "different", "stimuli", "showed", "that", "all", "produced", "C0879590#ent", "<e1>", "response", "to", "A23187", "C0022022#ent", "<e2>", "phorbol", "12-myristate", "13-acetate", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0022022", "name": "C0022022#ent", "pos": [26, 27]}}
{"token": ["The", "C0020443#ent", "<e1>", "effects", "of", "C0024027#ent", "<e2>", "can", "be", "potentiated", "by", "combination", "therapy", "other", "currently", "approved", "lipid", "lowering", "medications", "including", "bile", "acid", "sequestrants", "nicotinic", "acid"], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0024027", "name": "C0024027#ent", "pos": [5, 6]}}
{"token": ["However", ",", "under", "toxicity", "conditions", "associated", "with", "C2697656#ent", "<e1>", "doses", ",", "VIP", "and", "C1412228#ent", "<e2>", "could", "act", "as", "protective", "mediators", "regulate", "the", "excessive", "release", "of", "IL-6", "in", "order", "to", "reduce", "inflammation", "or", "shock", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412228", "name": "C1412228#ent", "pos": [13, 14]}}
{"token": ["AngII", "activates", "various", "signalling", "molecules", "including", "G-protein-derived", "second", "messengers", ",", "C0030940#ent", "<e1>", "small", "G-proteins", "Ras", ",", "Rho", ",", "C1705328#ent", "<e2>", "etc", ")", ",", "through", "the", "AT(1", ")", "receptor", "leading", "to", "vascular", "remodelling"], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705328", "name": "C1705328#ent", "pos": [18, 19]}}
{"token": ["Repeated", "administrations", "of", "C0039373#ent", "<e1>", "significantly", "enhanced", "perceived", "mood", "levels", "placebo-treated", "patients", ",", "while", "C0051607#ent", "<e2>", "administration", "blocked", "the", "antidepressant", "action", "of", "C0039373#ent", "<e1>", "."], "h": {"id": "C0039373", "name": "C0039373#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0051607", "name": "C0051607#ent", "pos": [14, 15]}}
{"token": ["We", "identified", "a", "group", "of", "23", "C1857355#ent", "<e1>", "cases", "belonging", "to", "17", "families", "affected", "by", "an", "autosomal", "recessive", "C0004134#ent", "<e2>", "associated", "with", "frequent", "white", "matter", "changes", "."], "h": {"id": "C1857355", "name": "C1857355#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [18, 19]}}
{"token": ["The", "mutations", "causing", "C1421313#ent", "<e1>", "were", "cotransducible", "with", "the", "C1420066#ent", "<e2>"], "h": {"id": "C1421313", "name": "C1421313#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420066", "name": "C1420066#ent", "pos": [9, 10]}}
{"token": ["Nikkomycins", "X", "Z", ",", "competitive", "inhibitors", "of", "fungal", "C0079115#ent", "<e1>", "were", "evaluated", "as", "therapeutic", "agents", "in", "vitro", "in", "mouse", "models", "C0009186#ent", "<e2>", ",", "histoplasmosis", ",", "and", "blastomycosis", "."], "h": {"id": "C0079115", "name": "C0079115#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009186", "name": "C0009186#ent", "pos": [20, 21]}}
{"token": ["Cyclospora", "respond", "well", "to", "co-trimoxazole", ",", "microsporidia", "respond", "variably", "to", "albendazole", ",", "and", "C0010418#ent", "<e1>", "can", "often", "be", "eradicated", "by", "C0068788#ent", "<e2>", "."], "h": {"id": "C0010418", "name": "C0010418#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0068788", "name": "C0068788#ent", "pos": [20, 21]}}
{"token": ["C0079504#ent", "<e1>", "HPS", ")", "is", "genetically", "heterogeneous", "and", "mutations", "in", "seven", "C1417679#ent", "<e2>", "have", "been", "reported", "to", "cause", "HPS", "."], "h": {"id": "C0079504", "name": "C0079504#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}}
{"token": ["These", "results", "show", "that", "C0002333#ent", "<e1>", "has", "a", "cardioprotective", "effect", "rats", "treated", "with", "damaging", "doses", "of", "C0022245#ent", "<e2>", "."], "h": {"id": "C0002333", "name": "C0002333#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [16, 17]}}
{"token": ["TCDD", "treatment", ",", "in", "vivo", "in", "vitro", "led", "to", "colocalization", "and", "translocation", "of", "NF-kappaB", "subunits", "p50", ",", "C1420556#ent", "<e1>", ")", "to", "the", "nucleus", "in", "stromal", "but", "not", "T", "cells", "C1706481#ent", "<e2>", "wild-type", "mice", "."], "h": {"id": "C1420556", "name": "C1420556#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1706481", "name": "C1706481#ent", "pos": [29, 30]}}
{"token": ["The", "general", "structure", "C1382029#ent", "<e1>", "composed", "of", "two", "cytoplasmic", "domains", "two", "C1417326#ent", "<e2>", "each", "of", "which", "contains", "6", "transmembrane", "spans", "(", "12", "spans", "in", "a", "molecule", ")", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417326", "name": "C1417326#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "the", "suppression", "of", "C1415076#ent", "<e1>", "expression", "in", "Caki-2", "cells", "by", "short", "interfering", "RNA", "the", "activation", "of", "C0242957#ent", "<e2>", "."], "h": {"id": "C1415076", "name": "C1415076#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [18, 19]}}
{"token": ["Increasing", "experimental", ",", "clinical", ",", "and", "epidemiological", "studies", "to", "the", "pivotal", "role", "of", "inflammation", "in", "the", "pathogenesis", "of", "acute", "and", "C0524851#ent", "<e1>", "to", "the", "protective", "effects", "nonsteroidal", "antiinflammatory", "drug", "C3536840#ent", "<e2>", ")", "therapies", "."], "h": {"id": "C0524851", "name": "C0524851#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3536840", "name": "C3536840#ent", "pos": [29, 30]}}
{"token": ["DATS", "treatment", "resulted", "in", "activation", "of", "extracellular-signal", "regulated", "kinase", "1/2", "ERK1/2", ")", "and", "c-jun", "N-terminal", "kinase", "1", "JNK1", ")", "and/or", "C1334482#ent", "<e1>", ",", "but", "not", "C1456378#ent", "<e2>"], "h": {"id": "C1334482", "name": "C1334482#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [25, 26]}}
{"token": ["In", "the", "presence", "of", "catecholamines", "(", "epinephrine", ",", "norepinephrine", ",", "isoproterenol", ",", "C0031469#ent", "<e1>", ")", "SQ", "22536", "reduced", "their", "activating", "effect", "on", "C0001492#ent", "<e2>", "both", "catfish", "and", "rat", "membranes", "."], "h": {"id": "C0031469", "name": "C0031469#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [22, 23]}}
{"token": ["C1623038#ent", "<e1>", "of", "the", "liver", "(", "standardized", "mortality", "ratio", "238", ")", "and", "C0175708#ent", "<e2>", "standardized", "mortality", "ratio", "199", ")", "were", "the", "only", "causes", "of", "death", "found", "to", "be", "significantly", "in", "excess", "."], "h": {"id": "C1623038", "name": "C1623038#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0175708", "name": "C0175708#ent", "pos": [12, 13]}}
{"token": ["The", "haematological", "parameters", "were", "determined", "using", "Coulter", "S", "automated", "counter", "the", "steady", "state", "periods", "while", "the", "AVEADM", "was", "computed", "from", "all", "admissions", "for", "C0030193#ent", "<e1>", "acute", "anaemia", "acute", "chest", "syndrome", "priapism", ",", "and", "C0038454#ent", "<e2>"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0038454", "name": "C0038454#ent", "pos": [33, 34]}}
{"token": ["In", "children", "with", "nasal", "discharge", "distinction", "between", "the", "group", "with", "a", "diagnosis", "of", "C0009443#ent", "<e1>", "and", "the", "group", "with", "a", "diagnosis", "of", "C0037199#ent", "<e2>", "was", "vague", "."], "h": {"id": "C0009443", "name": "C0009443#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [22, 23]}}
{"token": ["We", "then", "examined", "C1416677#ent", "<e1>", "mRNA", "expression", "using", "reverse", "transcription-polymerase", "chain", "reaction", "established", "its", "good", "concordance", "with", "C0534101#ent", "<e2>", "expression", "."], "h": {"id": "C1416677", "name": "C1416677#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0534101", "name": "C0534101#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "C1142183#ent", "<e1>", "infected", "BHK-2", "1", "cells", "were", "treated", "with", "C0037506#ent", "<e2>", "for", "increased", "sensitivity", "in", "antigen", "detection", "ELISA", "."], "h": {"id": "C1142183", "name": "C1142183#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [13, 14]}}
{"token": ["One", "hundred", "and", "nineteen", "patients", "who", "were", "operated", "on", "for", "C3489393#ent", "<e1>", "GERD", "were", "compared", "with", "89", "patients", "treated", "with", "proton", "pump", "inhibitor", "C0028978#ent", "<e2>", "concerning", "bronchial", "symptoms", "before", "and", "after", "treatment", "."], "h": {"id": "C3489393", "name": "C3489393#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [23, 24]}}
{"token": ["min", ")", "begun", "60", "min", "before", "the", "administration", "of", "metoclopramide", "markedly", "decreased", "the", "18-OHB", "as", "well", "as", "the", "aldosterone", "and", "C1418938#ent", "<e1>", "responses", "to", "the", "C0178601#ent", "<e2>"], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0178601", "name": "C0178601#ent", "pos": [25, 26]}}
{"token": ["Rather", ",", "RACK1", "selectively", "inhibits", "G", "betagamma-stimulated", "phosphatidylinositol", "3-kinase", "gamma", "C1705590#ent", "<e1>", "and", "phospholipase", "C", "C2987154#ent", "<e2>", ")", "beta", "activity", "due", "to", "the", "competitive", "binding", "RACK1", ",", "C1705590#ent", "<e1>", "and", "PLC", "beta", "to", "G", "betagamma"], "h": {"id": "C2987154", "name": "C2987154#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [10, 11]}}
{"token": ["Combination", "of", "C1366515#ent", "<e1>", "and", "paramagnetic", "1H", "NMR", "shows", "that", "the", "C0040263#ent", "<e2>", "the", "zinc", "species", "be", "further", "extended", "to", "the", "iron(III)", "species", "in", "dilute", "conditions", "."], "h": {"id": "C1366515", "name": "C1366515#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0040263", "name": "C0040263#ent", "pos": [11, 12]}}
{"token": ["Using", "these", "methods", ",", "and", "a", "highly", "sensitive", "immunofluorometric", "assay", "measuring", "C0070942#ent", "<e1>", "we", "have", "assessed", "the", "concentrations", "of", "C1426033#ent", "<e2>", "mRNA", "and", "C0070942#ent", "<e1>", "30", "primary", "breast", "tumors", "a", "few", "other", "control", "tissues"], "h": {"id": "C1426033", "name": "C1426033#ent", "pos": [19, 20]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0070942", "name": "C0070942#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "child", "who", "underwent", "a", "T-depleted", "unrelated", "donor", "bone", "marrow", "transplant", "severe", "C0002874#ent", "<e1>", "a", "manifestation", "of", "Schwachman-Diamond", "syndrome", "developed", "severe", "C0948441#ent", "<e2>", "."], "h": {"id": "C0002874", "name": "C0002874#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0948441", "name": "C0948441#ent", "pos": [23, 24]}}
{"token": ["This", "review", "summarizes", "our", "current", "understanding", "of", "human", "iron", "metabolism", "focuses", "on", "the", "clinically", "relevant", "features", "of", "hereditary", "and", "secondary", "hemochromatosis", "C0162316#ent", "<e1>", "anemia", "of", "chronic", "disease", "anemia", "of", "C0221423#ent", "<e2>"], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0221423", "name": "C0221423#ent", "pos": [29, 30]}}
{"token": ["Further", "MS", "C1456390#ent", "<e1>", "led", "to", "detection", "of", "two", "post-translationally", "modified", "variants", "of", "C1419788#ent", "<e2>", ",", "namely", "glutathionylated", "and", "cysteinylated", "forms", "."], "h": {"id": "C1456390", "name": "C1456390#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419788", "name": "C1419788#ent", "pos": [13, 14]}}
{"token": ["These", "C0086376#ent", "<e1>", "were", "not", "induced", "by", "an", "alkylating", "agent", "antitumor", "antibiotics", "or", "an", "C3536950#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3536950", "name": "C3536950#ent", "pos": [14, 15]}}
{"token": ["C0011777#ent", "<e1>", "potentiates", "the", "effect", "of", "FSH", "on", "granulosa", "cell", ",", "whereas", "C1366557#ent", "<e2>", "counteracts", "the", "effect", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366557", "name": "C1366557#ent", "pos": [12, 13]}}
{"token": ["Agar", "culture", "analyses", "and", "a", "specific", "Escherichia", "coli", "C0005220#ent", "<e1>", "carried", "out", "to", "detect", "gut", "indigenous", "bacterial", "invasion", "intestinal", "wall", "extraintestinal", "mesenteric", "lymph", "nodes", "C1417190#ent", "<e2>", ")", "."], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417190", "name": "C1417190#ent", "pos": [24, 25]}}
{"token": ["Enzyme", "activity", "poorly", "expressed", "in", "the", "absence", "of", "thiol", "groups", "the", "presence", "of", "monothioglycerol", "stimulating", "C0567085#ent", "<e1>", "and", "chorion", "C3541394#ent", "<e2>", "by", "5-", "and", "15-fold", ",", "respectively", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [19, 20]}}
{"token": ["11-deoxy", "PGE1", "16,16-dimethyl", "PGE2", "and", "C0085174#ent", "<e1>", "were", "all", "full", "agonists", "at", "this", "receptor", ",", "whilst", "C0215899#ent", "<e2>", "was", "a", "low", "potency", "agonist", ",", "and", "sulprostone", "was", "inactive", "."], "h": {"id": "C0085174", "name": "C0085174#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0215899", "name": "C0215899#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "to", "these", "subtle", "C1420816#ent", "<e1>", "effects", "shared", "by", "many", "viruses", ",", "C0021400#ent", "<e2>", "and", "paramyxoviruses", "activate", "a", "respiratory", "burst", "phagocytic", "cells"], "h": {"id": "C1420816", "name": "C1420816#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [13, 14]}}
{"token": ["One", "sporadic", "chondrosarcoma", "LOH", "for", "EXT1", "and", "C1414488#ent", "<e1>", ",", "while", "a", "second", "underwent", "LOH", "for", "C0694879#ent", "<e2>", "and", "chromosome", "10"], "h": {"id": "C1414488", "name": "C1414488#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0694879", "name": "C0694879#ent", "pos": [16, 17]}}
{"token": ["High", "plasma", "homocysteine", "concentration", "had", "a", "direct", "effect", "on", "the", "risk", "of", "C3813548#ent", "<e1>", "independent", "of", "C0066357#ent", "<e2>", "677C-->T", "genotypes", "."], "h": {"id": "C3813548", "name": "C3813548#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0066357", "name": "C0066357#ent", "pos": [16, 17]}}
{"token": ["The", "reduction", "in", "mRNA", "levels", "and", "the", "general", "transcriptional", "repression", "both", "dependent", "on", "C1458146#ent", "<e1>", "encoded", "by", "C1336656#ent", "<e2>", ")", "."], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [13, 14]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1336656", "name": "C1336656#ent", "pos": [17, 18]}}
{"token": ["Vesicular", "transport", "the", "endoplasmic", "reticulum", "ER", ")", "and", "the", "C1423498#ent", "<e1>", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "a", "C0812284#ent", "<e2>", ",", "small", "GTP-binding", "protein", "Sar1p", "[", "1", "-", "3", "]", "."], "h": {"id": "C1423498", "name": "C1423498#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0812284", "name": "C0812284#ent", "pos": [17, 18]}}
{"token": ["The", "molecular", "genetic", "clinical", "data", "C0010691#ent", "<e1>", "patients", "and", "their", "relatives", "were", "combined", "to", "construct", "the", "C1420228#ent", "<e2>", "haplotypes", "and", "evaluate", "the", "manifestation", "of", "the", "disorder", "in", "carriers", "for", "a", "SLC7A9", "gene", "mutation", "."], "h": {"id": "C0010691", "name": "C0010691#ent", "pos": [5, 6]}, "relation": "disease_has_associated_gene", "t": {"id": "C1420228", "name": "C1420228#ent", "pos": [16, 17]}}
{"token": ["Putative", "androgen", "and", "estrogen", "response", "elements", "present", "in", "the", "promoters", "of", "several", "of", "these", "C0017376#ent", "<e1>", "suggesting", "the", "propensity", "for", "C0038317#ent", "<e2>", "directly", "affect", "dimorphic", "antiviral", "responses", "Seoul", "virus", "infection"], "h": {"id": "C0017376", "name": "C0017376#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [20, 21]}}
{"token": ["Glucoamylase", ",", "invertase", ",", "and", "C0007641#ent", "<e1>", "were", "entrapped", "within", "poly(vinyl", "alcohol", ")", "(", "C1414170#ent", "<e2>", ")", "membrane", "cross-linked", "by", "means", "of", "irradiation", "of", "ultraviolet", "light"], "h": {"id": "C0007641", "name": "C0007641#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414170", "name": "C1414170#ent", "pos": [14, 15]}}
{"token": ["We", "investigated", "whether", "intravenous", "C0360097#ent", "<e1>", "prior", "to", "endotracheal", "intubation", "influences", "the", "postoperative", "airway", "symptoms", "of", "C0031350#ent", "<e2>", "cough", ",", "and", "sputum", "."], "h": {"id": "C0360097", "name": "C0360097#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031350", "name": "C0031350#ent", "pos": [16, 17]}}
{"token": ["More", "recently", ",", "the", "HIV", "Dementia", "Scale", "C1427027#ent", "<e1>", ")", "was", "developed", "as", "a", "bedside", "evaluation", "test", "differentiate", "patients", "with", "C0019686#ent", "<e2>", "frank", "dementia", "from", "those", "who", "are", "cognitively", "normal", "."], "h": {"id": "C1427027", "name": "C1427027#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019686", "name": "C0019686#ent", "pos": [20, 21]}}
{"token": ["A", "3-year-old", "female", "receiving", "Pediazole", "(", "erythromycin", "ethylsuccinate", "and", "C0038745#ent", "<e1>", ")", "for", "tonsillitis", "and", "C0029882#ent", "<e2>", "severe", "hemolytic", "anemia"], "h": {"id": "C0038745", "name": "C0038745#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0029882", "name": "C0029882#ent", "pos": [15, 16]}}
{"token": ["Lower", "forward-mutation", "frequencies", "than", "were", "found", "in", "C2987364#ent", "<e1>", "were", "obtained", "with", "uvs-2", "after", "C0020775#ent", "<e2>", "treatment", "and", "with", "uvs-5", "after", "MNNG", ",", "4NQO", "or", "C0020775#ent", "<e2>", "treatment", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020775", "name": "C0020775#ent", "pos": [14, 15]}}
{"token": ["Two", "isozymes", "have", "been", "identified", ":", "11beta", "HSD", "type", "1", "a", "predominant", "reductase", ",", "reactivating", "glucocorticoids", "from", "inert", "metabolites", "whereas", "11beta", "C3890918#ent", "<e1>", "a", "potent", "C0024544#ent", "<e2>", ",", "inactivating", "glucocorticoids", "."], "h": {"id": "C3890918", "name": "C3890918#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [25, 26]}}
{"token": ["There", "was", "a", "significant", "increase", "in", "fibrous", "tissue", "the", "urethrovaginal", "septum", ",", "accompanied", "by", "a", "loss", "of", "smooth", "muscle", "fibres", "focal", "clumping", "C0013765#ent", "<e1>", "in", "patients", "with", "the", "C0156279#ent", "<e2>"], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0156279", "name": "C0156279#ent", "pos": [28, 29]}}
{"token": ["With", "the", "use", "of", "a", "renin-luciferase", "reporter", "system", "in", "As4.1", "cells", ",", "C3273437#ent", "<e1>", "reduced", "luciferase", "activity", "51", "%", ",", "suggesting", "that", "C1710463#ent", "<e2>", "directly", "modified", "by", "C3273437#ent", "<e1>", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [12, 13]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [22, 23]}}
{"token": ["C1134446#ent", "<e1>", "induction", "by", "dietary", "butylated", "hydroxyanisole", "inhibition", "by", "C0056764#ent", "<e2>", "the", "rate", "of", "hepatic", "microsomal", "formation", "of", "naphthalene", "dihydrodiol", "the", "expected", "manner", "and", "increased", "the", "production", "of", "conjugate", "peak", "2"], "h": {"id": "C1134446", "name": "C1134446#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0056764", "name": "C0056764#ent", "pos": [9, 10]}}
{"token": ["To", "clarify", "the", "effects", "of", "bedtime", "administration", "of", "the", "centrally", "acting", ",", "C0018312#ent", "<e1>", "and", "clonidine", ",", "on", "C0020538#ent", "<e2>"], "h": {"id": "C0018312", "name": "C0018312#ent", "pos": [12, 13]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["The", "present", "study", "describes", "the", "cellular", "effects", "a", "new", "dihydropyridine", "analogue", "C0169798#ent", "<e1>", ",", "on", "P-gp-mediated", "resistance", "to", "C0146224#ent", "<e2>", "in", "human", "breast", "and", "ovarian", "tumour", "cells"], "h": {"id": "C0169798", "name": "C0169798#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0146224", "name": "C0146224#ent", "pos": [18, 19]}}
{"token": ["The", "clinical", "signs", "C0020437#ent", "<e1>", "and", "elevated", "serum", "concentrations", "of", "1,25", "dihydroxyvitamin", "D", "following", "C0032950#ent", "<e2>", "treatment", "."], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [14, 15]}}
{"token": ["Her", "C0020437#ent", "<e1>", "was", "partially", "corrected", "by", "C0032950#ent", "<e2>", ",", "but", "resolved", "with", "the", "addition", "of", "cellulose", "phosphate"], "h": {"id": "C0020437", "name": "C0020437#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [7, 8]}}
{"token": ["S-1", "is", "a", "novel", "oral", "fluorouracil", "antitumor", "drug", "combines", "tegafur", "(", "FT", ")", ",", "C0535459#ent", "<e1>", "(", "CDHP", ")", ",", "which", "inhibits", "C1366555#ent", "<e2>", "DPD", ")", ",", "and", "potassium", "oxonate", "Oxo", ")", "."], "h": {"id": "C0535459", "name": "C0535459#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1366555", "name": "C1366555#ent", "pos": [22, 23]}}
{"token": ["S-1", "is", "an", "oral", "5-FU", "anti-tumor", "drug", "combines", "three", "pharmacological", "agents", "tegafur", ",", "C0535459#ent", "<e1>", ",", "which", "inhibits", "C1366555#ent", "<e2>", ",", "and", "potassium", "oxonate", "which", "reduces", "gastrointestinal", "toxicity"], "h": {"id": "C0535459", "name": "C0535459#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1366555", "name": "C1366555#ent", "pos": [18, 19]}}
{"token": ["The", "C3543842#ent", "<e1>", "component", "of", "the", "K+", "response", "more", "affected", "by", "the", "C1562036#ent", "<e2>", "the", "phasic", "component", "."], "h": {"id": "C3543842", "name": "C3543842#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1562036", "name": "C1562036#ent", "pos": [12, 13]}}
{"token": ["To", "test", "this", "idea", ",", "we", "have", "used", "in", "vitro", "translation", "of", "PLD1", "and", "C1418642#ent", "<e1>", "which", "generated", "active", "C3540790#ent", "<e2>", "exhibiting", "properties", "mimicking", "those", "of", "the", "endogenous", "proteins", "."], "h": {"id": "C1418642", "name": "C1418642#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [19, 20]}}
{"token": ["Immunoisolated", "HA-tagged", "PLD1", "and", "C1418642#ent", "<e1>", "are", "not", "stimulated", "by", "the", "peptides", ",", "although", "both", "C3540790#ent", "<e2>", "retain", "sensitivity", "to", "their", "inhibitory", "effect"], "h": {"id": "C1418642", "name": "C1418642#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [15, 16]}}
{"token": ["Only", "CDs", "that", "lowered", "cholesterol", "levels", "redistributed", "the", "NMDA", "receptor", "NR2B", "subunit", ",", "PSD-95", "(", "postsynaptic", "density", "protein", "95", "kDa", "and", "C0669368#ent", "<e1>", "nNOS", ")", "from", "C0146951#ent", "<e2>", "insoluble", "membrane", "domains", "soluble", "fractions", "."], "h": {"id": "C0669368", "name": "C0669368#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0146951", "name": "C0146951#ent", "pos": [26, 27]}}
{"token": ["We", "previously", "reported", "that", "mice", "lacking", "C2987364#ent", "<e1>", "HIF-2alpha", ",", "encoded", "by", "the", "EPAS1", "gene", "exhibit", "C0015625#ent", "<e2>", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015625", "name": "C0015625#ent", "pos": [16, 17]}}
{"token": ["Demethylation", "of", "dimethylvinphos", "occurs", "in", "liver", "fractions", "the", "action", "of", "two", "C3540772#ent", "<e1>", ":", "glutathione", "S-methyl", "transferase", "the", "cytosol", ",", "and", "C1620185#ent", "<e2>"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [21, 22]}}
{"token": ["Histophilus", "somni", "Haemophilus", "somnus", "is", "an", "obligate", "inhabitant", "of", "the", "mucosal", "surfaces", "of", "bovines", "and", "sheep", "and", "an", "opportunistic", "pathogen", "for", "C0035204#ent", "<e1>", "meningoencephalitis", ",", "myocarditis", ",", "arthritis", ",", "and", "other", "C0153252#ent", "<e2>"], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0153252", "name": "C0153252#ent", "pos": [31, 32]}}
{"token": ["We", "describe", "our", "experience", "managing", "a", "16-year-old", "girl", "with", "systemic", "lupus", "erythematosus", "SLE", ")", "who", "presented", "concomitantly", "with", "rapidly", "C0017658#ent", "<e1>", "RPGN", ")", "and", "a", "C2717961#ent", "<e2>", "TMAHA", ")", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [25, 26]}}
{"token": ["These", "observations", "suggest", "that", "constitutional", "dysregulation", "of", "the", "alternative", "pathway", "associated", "with", "wide", "spectrum", "of", "kidney", "diseases", "and", "C0017658#ent", "<e1>", "with", "isolated", "C3", "deposits", "C2717961#ent", "<e2>", "be", "different", "expressions", "of", "the", "same", "condition", "."], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2717961", "name": "C2717961#ent", "pos": [24, 25]}}
{"token": ["Current", "research", "evidence", "suggests", "that", "interactions", "between", "genetic", "and", "environmental", "factors", "to", "modulate", "the", "susceptibility", "to", "C0154671#ent", "<e1>", "including", "inflammatory", "and", "C0004364#ent", "<e2>", "the", "central", "nervous", "system", "CNS", ")", "."], "h": {"id": "C0154671", "name": "C0154671#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [21, 22]}}
{"token": ["We", "also", "detected", "gene", "expression", "SIRPalpha", ",", "anti-apoptotic", "A-20", ",", "signal", "regulatory", "C1705639#ent", "<e1>", "and", "BCAR3", ",", "DNA", "binding", "proteins", "EGR2", "and", "C1412793#ent", "<e2>", "in", "addition", "to", "some", "new", "genes", "."], "h": {"id": "C1705639", "name": "C1705639#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412793", "name": "C1412793#ent", "pos": [22, 23]}}
{"token": ["The", "crystal", "structures", "the", "human", "androgen", "receptor", "hAR", ")", "and", "human", "C1366500#ent", "<e1>", "ligand-binding", "domains", "complex", "with", "the", "same", "ligand", "metribolone", "C0878449#ent", "<e2>", ")", "have", "been", "determined", "."], "h": {"id": "C1366500", "name": "C1366500#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0878449", "name": "C0878449#ent", "pos": [21, 22]}}
{"token": ["Therefore", ",", "effects", "on", "C1413043#ent", "<e1>", "+", "membrane", "transport", "be", "involved", "in", "acute", "C1705616#ent", "<e2>", "actions", "on", "hormonal", "activity", "these", "HPG", "sites", "."], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [13, 14]}}
{"token": ["Experimental", "ventilator-associated", "C0006246#ent", "<e1>", "is", "frequently", "C0275524#ent", "<e2>", ",", "and", "bacterial", "lung", "burden", "increases", "with", "the", "severity", "of", "lung", "infection"], "h": {"id": "C0006246", "name": "C0006246#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [6, 7]}}
{"token": ["Allele", "frequencies", "C1539081#ent", "<e1>", "did", "not", "differ", "from", "controls", "in", "patients", "with", "C0677607#ent", "<e2>"], "h": {"id": "C1539081", "name": "C1539081#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [12, 13]}}
{"token": ["Because", "of", "the", "effectiveness", "of", "C0022209#ent", "<e1>", "in", "treating", "tuberculosis", "infection", "progression", "to", "C0041296#ent", "<e2>", "should", "be", "largely", "preventable", "."], "h": {"id": "C0022209", "name": "C0022209#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [13, 14]}}
{"token": ["Molecular", "diagnosis", "unfeasible", "because", "the", "C1858664#ent", "<e1>", "still", "unknown", ",", "although", "it", "is", "known", "that", "the", "C0277565#ent", "<e2>", "to", "chromosome", "1q"], "h": {"id": "C1858664", "name": "C1858664#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [16, 17]}}
{"token": ["We", "assessed", "bone", "mineral", "density", "C1826421#ent", "<e1>", ")", "and", "body", "composition", "children", "with", "C0028326#ent", "<e2>", "NS", ")", "before", "and", "during", "growth", "hormone", "GH", ")", "treatment", "."], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0028326", "name": "C0028326#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "HOE", "668", "against", "C0023290#ent", "<e1>", "superior", "to", "that", "of", "C0030864#ent", "<e2>", "the", "pentavalent", "antimonial", "drugs", ",", "sodium", "stibogluconate", "N-methylglucamine", "antimoniate"], "h": {"id": "C0023290", "name": "C0023290#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0030864", "name": "C0030864#ent", "pos": [12, 13]}}
{"token": ["The", "35", "C0072366#ent", "<e1>", "finally", "identified", "as", "C1414968#ent", "<e2>", "properties", "such", "as", "mobility", "on", "SDS-polyacrylamide", "gel", "electrophoresis", "cleavage", "pattern", "on", "limited", "proteolysis", ",", "ability", "to", "bind", "to", "tubulin", ",", "and", "so", "on", "."], "h": {"id": "C0072366", "name": "C0072366#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414968", "name": "C1414968#ent", "pos": [7, 8]}}
{"token": ["In", "the", "xenografted", "heart", "treated", "with", "C3889643#ent", "<e1>", "compounds", ",", "no", "pathologic", "changes", "such", "as", "C0010072#ent", "<e2>", "to", "hyperacute", "rejection", "had", "occurred", "by", "3", "-", "4", "h", "after", "reperfusion", ",", "and", "the", "endothelial", "cells", "well", "preserved", "."], "h": {"id": "C3889643", "name": "C3889643#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010072", "name": "C0010072#ent", "pos": [15, 16]}}
{"token": ["The", "combination", "of", "highly", "effective", "inhibition", "of", "prostaglandin", "H", "synthase", "prostacyclin", "receptor-mediated", "vasodilation", "may", "contribute", "to", "the", "increased", "efficacy", "of", "indomethacin", "compared", "with", "other", "C0033529#ent", "<e1>", "blocking", "certain", "C0042402#ent", "<e2>", "associated", "with", "prostanoids", "."], "h": {"id": "C0033529", "name": "C0033529#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [28, 29]}}
{"token": ["Furthermore", ",", "we", "observed", "no", "effect", "invariant", "chain", "processing", "C1456349#ent", "<e1>", "inhibition", "for", "several", "distinct", "allelic", "variants", "of", "C0017349#ent", "<e2>"], "h": {"id": "C1456349", "name": "C1456349#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017349", "name": "C0017349#ent", "pos": [18, 19]}}
{"token": ["Within", "3", "days", ",", "the", "alginate-seeded", "cells", "expressed", "genes", "for", "mature", "liver", "enzymes", "such", "as", "C0041256#ent", "<e1>", "secreted", "a", "high", "level", "of", "C1412332#ent", "<e2>", ",", "and", "performed", "phase", "I", "drug", "metabolism"], "h": {"id": "C0041256", "name": "C0041256#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [22, 23]}}
{"token": ["Treatment", "with", "low-dose", "insulin", "(", "to", "control", "for", "the", "transient", "glucose-lowering", "effects", "of", "C1334089#ent", "<e1>", ")", "failed", "to", "affect", "the", "frequency", "of", "ganglionic", "or", "C0270724#ent", "<e2>", "the", "severity", "of", "diabetes", "."], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0270724", "name": "C0270724#ent", "pos": [24, 25]}}
{"token": ["The", "DMSO-induced", "upregulation", "of", "C1430988#ent", "<e1>", "might", "be", "mediated", "by", "NF-kappaB", "activation", "which", "was", "evidenced", "by", "the", "blockage", "of", "DMSO-induced", "C1430988#ent", "<e1>", "upregulation", "with", "an", "NF-kappaB", "inhibitor", "C0163305#ent", "<e1>", "PDTC", ")", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0163305", "name": "C0163305#ent", "pos": [27, 28]}}
{"token": ["The", "mean", "apparent", "C3889265#ent", "<e1>", "value", "for", "C2343921#ent", "<e2>", "(", "with", "95", "%", "C.L.", ")", "in", "the", "control", "group", "7.7", "(", "7.5", ",", "7.9", ")", "."], "h": {"id": "C3889265", "name": "C3889265#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2343921", "name": "C2343921#ent", "pos": [7, 8]}}
{"token": ["The", "paper", "describes", "the", "results", "of", "comparatively", "analyzing", "the", "parameters", "of", "apoptosis", ",", "micro-", "and", "macroelement", "spectrum", "of", "peripheral", "blood", "lymphocytes", "healthy", "donors", "in", "patients", "with", "C0024117#ent", "<e1>", "COPD", ")", "and", "C0041327#ent", "<e2>"], "h": {"id": "C0024117", "name": "C0024117#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [31, 32]}}
{"token": ["The", "O-acetyl", "group", "located", "on", "O-3", "of", "the", "C1825858#ent", "<e1>", "and", "the", "structure", "of", "the", "C0032594#ent", "<e2>", "can", "be", "written", "as", "[", "sequence", ":", "see", "text", "]"], "h": {"id": "C1825858", "name": "C1825858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [15, 16]}}
{"token": ["Own", "investigations", "show", "that", "the", "pancytopenia", "in", "HCL", "is", "a", "result", "of", "a", "lack", "of", "C1334117#ent", "<e1>", "a", "dominance", "of", "C3669283#ent", "<e2>", "as", "TNF-alpha", "."], "h": {"id": "C1334117", "name": "C1334117#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3669283", "name": "C3669283#ent", "pos": [20, 21]}}
{"token": ["We", "found", "that", "these", "genes", "encoding", "mitochondrial", "proteases", "C1421554#ent", "<e1>", "and", "MPP", "beta", ",", "import", "component", "C1424895#ent", "<e2>", "and", "enzymes", "NDUFB2", ",", "endonuclease", "G", "thioredoxin", "2", "all", "contain", "a", "CHOP", "element", "in", "their", "promoters", "."], "h": {"id": "C1421554", "name": "C1421554#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1424895", "name": "C1424895#ent", "pos": [16, 17]}}
{"token": ["C0149887#ent", "<e1>", "to", "be", "associated", "with", "variety", "of", "C0014130#ent", "<e2>", "particularly", "hypothyroidism", "."], "h": {"id": "C0149887", "name": "C0149887#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [8, 9]}}
{"token": ["The", "first", "member", "of", "this", "group", "of", "C0086376#ent", "<e1>", "was", "identified", "in", "a", "Staphylococcus", "aureus", "C3668816#ent", "<e2>", "isolate", "and", "was", "named", "Bap", "(", "biofilm-associated", "protein", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3668816", "name": "C3668816#ent", "pos": [15, 16]}}
{"token": ["The", "second", "set", "of", "experiments", "demonstrated", "that", "localized", "cholinergic", "stimulation", "of", "the", "P-wave", "generator", "increased", "expression", "of", "C1854562#ent", "<e1>", ",", "BDNF", "and", "Egr-1", "mRNAs", "in", "the", "C0171406#ent", "<e2>", "."], "h": {"id": "C1854562", "name": "C1854562#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [26, 27]}}
{"token": ["C0030956#ent", "<e1>", "c-fos", "mRNA", "were", "undetectable", "in", "control", "animals", "and", "C0812302#ent", "<e2>", "immunoreactivity", "increased", "in", "a", "dose-dependent", "manner", "following", "i.p", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812302", "name": "C0812302#ent", "pos": [10, 11]}}
{"token": ["C0010324#ent", "<e1>", "CN-I", ")", "is", "a", "rare", "and", "severe", "C0025517#ent", "<e2>"], "h": {"id": "C0010324", "name": "C0010324#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}}
{"token": ["C4283742#ent", "<e1>", "did", "not", "depress", "baseline", "C2744579#ent", "<e2>", "levels", "but", "did", "accelerate", "the", "rate", "of", "the", "decline", "in", "C2744579#ent", "<e2>", "concentrations", "observed", "during", "the", "metabolic", "insults", "."], "h": {"id": "C4283742", "name": "C4283742#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [6, 7]}}
{"token": ["FB-positive", "neurones", "containing", "C1420718#ent", "<e1>", ",", "NPY", ",", "VIP", "and", "C0059338#ent", "<e2>", "were", "numerous", ",", "while", "those", "containing", "CGRP", "were", "scarce", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059338", "name": "C0059338#ent", "pos": [10, 11]}}
{"token": ["We", "report", "that", "Lim-domain", "only", "7", "(", "C1416885#ent", "<e1>", ")", "binds", "C0295734#ent", "<e2>", "directly", "with", "125", "nM", "affinity", ";", "the", "C-terminal", "half", "human", "C1416885#ent", "<e1>", "(", "hLmo7C", ")", "was", "sufficient", "to", "bind", "C0295734#ent", "<e2>", "in", "vitro"], "h": {"id": "C0295734", "name": "C0295734#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416885", "name": "C1416885#ent", "pos": [7, 8]}}
{"token": ["C0007965#ent", "<e1>", "is", "related", "to", "one", "gene", ":", "C1537630#ent", "<e2>", "."], "h": {"id": "C0007965", "name": "C0007965#ent", "pos": [0, 1]}, "relation": "disease_has_associated_gene", "t": {"id": "C1537630", "name": "C1537630#ent", "pos": [8, 9]}}
{"token": ["In", "the", "C1704827#ent", "<e1>", "group", ",", "MABP", "markedly", "increased", "with", "rises", "in", "plasma", "C1708407#ent", "<e2>", "and", "ANP", ",", "but", "urine", "flow", "urinary", "osmolality", "and", "urinary", "Na", "and", "K", "excretion", "decreased", "."], "h": {"id": "C1704827", "name": "C1704827#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1708407", "name": "C1708407#ent", "pos": [13, 14]}}
{"token": ["There", "was", "no", "correlation", "between", "C0003805#ent", "<e1>", "values", "and", "either", "C1366644#ent", "<e2>", "or", "PR", "and", "also", "no", "correlation", "between", "C1366644#ent", "<e2>", "and", "PR", "and", "response", "to", "aminoglutethimide", "."], "h": {"id": "C0003805", "name": "C0003805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366644", "name": "C1366644#ent", "pos": [10, 11]}}
{"token": ["C0085084#ent", "<e1>", "as", "scleroderma", "(", "ScI", ")", ",", "C0035436#ent", "<e2>", "PR", ")", ",", "Gougerot-Sj\u00f6gren", "Syndrome", "(", "GS", ")", "have", "a", "well", "known", "propensity", "for", "the", "lungs", "."], "h": {"id": "C0085084", "name": "C0085084#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035436", "name": "C0035436#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "Arg776", "is", "conserved", "in", "a", "diversity", "of", "eukaryotic", "and", "prokaryotic", "proteins", "posses", "a", "domain", "C1512488#ent", "<e1>", "to", "the", "C-terminal", "domain", "C0948368#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0948368", "name": "C0948368#ent", "pos": [22, 23]}}
{"token": ["The", "distribution", "of", "detectable", "antibodies", "against", "antigen", "Dd", "has", "been", "studied", "in", "rheumatoid", "arthritis", "goitre", ",", "nephrotic", "syndrome", "C0023890#ent", "<e1>", ",", "gastrointestinal", "tract", "diseases", "neurological", "diseases", "liver", "and", "C0016977#ent", "<e2>", "breast", "cancer", "respiratory", "diseases", "cardiovascular", "diseases"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0016977", "name": "C0016977#ent", "pos": [28, 29]}}
{"token": ["C0162316#ent", "<e1>", "anaemia", "is", "one", "of", "most", "prevalent", "C3714509#ent", "<e2>", "."], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3714509", "name": "C3714509#ent", "pos": [8, 9]}}
{"token": ["When", "it", "does", "not", "depend", "on", "foods", "it", "is", "used", "a", "prophylactic", "pharmacotherapy", "C0019590#ent", "<e1>", ",", "cromones", "or", "C0074722#ent", "<e2>"], "h": {"id": "C0019590", "name": "C0019590#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0074722", "name": "C0074722#ent", "pos": [18, 19]}}
{"token": ["The", "function", "of", "thrombopoietin", "(", "C0812443#ent", "<e1>", ")", "in", "megakaryocytopoiesis", "and", "thrombopoiesis", "as", "well", "as", "its", "chromosomal", "location", "marked", "C0812443#ent", "<e1>", "as", "a", "candidate", "C0079429#ent", "<e1>", "for", "malignancies", "with", "3q", "rearrangements", "with", "dysmegakaryopoiesis", "."], "h": {"id": "C0812443", "name": "C0812443#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [24, 25]}}
{"token": ["None", "of", "nine", "family", "contacts", "of", "those", "with", "C1413603#ent", "<e1>", "appeared", "to", "shed", "C0001486#ent", "<e2>", "in", "stool", "."], "h": {"id": "C1413603", "name": "C1413603#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [13, 14]}}
{"token": ["Major", "drugs", "used", "in", "the", "management", "of", "C0014547#ent", "<e1>", "are", "phenytoin", ",", "phenobarbital", ",", "C0033148#ent", "<e2>", ",", "carbamazepine", ",", "ethosuximide", "and", "valproic", "acid"], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0033148", "name": "C0033148#ent", "pos": [14, 15]}}
{"token": ["Moreover", ",", "many", "growth", "factors", "i.e.", ",", "IGF-I", ",", "C1416377#ent", "<e1>", "PTHrP", ",", "fibroblast", "growth", "factors", "bone", "morphogenetic", "proteins", "and", "C1522575#ent", "<e2>", "are", "now", "considered", "as", "crucial", "regulators", "of", "chondrocyte", "proliferation", "differentiation", "."], "h": {"id": "C1416377", "name": "C1416377#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1522575", "name": "C1522575#ent", "pos": [20, 21]}}
{"token": ["The", "enzymes", "have", "been", "identified", "as", "aldehyde", "dehydrogenase", "EC", "1.2.1.3", ")", ",", "C0075426#ent", "<e1>", "EC", "1.2.1.24", ")", ",", "and", "C1414968#ent", "<e2>", "EC", "1.2.1.12", "."], "h": {"id": "C0075426", "name": "C0075426#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414968", "name": "C1414968#ent", "pos": [19, 20]}}
{"token": ["Only", "four", "had", "a", "diagnosis", "of", "C0455990#ent", "<e1>", "while", "the", "remainder", "had", "varied", "C0455988#ent", "<e2>", "causes", "."], "h": {"id": "C0455990", "name": "C0455990#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0455988", "name": "C0455988#ent", "pos": [13, 14]}}
{"token": ["The", "C1321567#ent", "<e1>", "response", "to", "C0011501#ent", "<e2>", "was", "not", "affected", "in", "any", "of", "the", "experimental", "groups"], "h": {"id": "C1321567", "name": "C1321567#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011501", "name": "C0011501#ent", "pos": [5, 6]}}
{"token": ["Consistent", "with", "data", "in", "the", "literature", ",", "the", "author", "is", "in", "favour", "of", "the", "view", "that", "the", "C0235031#ent", "<e1>", "mitral", "with", "C0026267#ent", "<e2>", "conditioned", "by", "a", "thromboembolic", "mechanism", "."], "h": {"id": "C0235031", "name": "C0235031#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0026267", "name": "C0026267#ent", "pos": [21, 22]}}
{"token": ["It", "seems", "to", "be", "justified", "to", "consider", "C0032064#ent", "<e1>", "a", "cause", "of", "C1843274#ent", "<e2>"], "h": {"id": "C0032064", "name": "C0032064#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1843274", "name": "C1843274#ent", "pos": [12, 13]}}
{"token": ["This", "increase", "could", "account", "for", "suppressed", "circulating", "renin", ",", "the", "exaggerated", "renal", "vasodilator", "response", "C0288171#ent", "<e1>", ",", "and", "the", "therapeutic", "effectiveness", "interrupting", "the", "renin", "system", "C0011881#ent", "<e2>"], "h": {"id": "C0288171", "name": "C0288171#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [25, 26]}}
{"token": ["C0040247#ent", "<e1>", "and", "onychomycosis", "and", "cryptococcuria", "also", "improved", "in", "the", "C0016277#ent", "<e2>", "patients", ",", "and", "fungal", "colonization", "was", "significantly", "decreased", "."], "h": {"id": "C0040247", "name": "C0040247#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [10, 11]}}
{"token": ["Finally", ",", "treatment", "of", "neutrophils", "with", "the", "C0010531#ent", "<e1>", "inhibitor", "H-89", "prevented", "PGE2-", "and", "C2987048#ent", "<e2>", "20", "-", "1724-induced", "inhibition", "of", "cell", "apoptosis"], "h": {"id": "C0010531", "name": "C0010531#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987048", "name": "C2987048#ent", "pos": [14, 15]}}
{"token": ["Thus", ",", "we", "have", "analyzed", "the", "effects", "of", "two", "major", "OMPs", "(", "C1425923#ent", "<e1>", "and", "Omp31", ")", "of", "Brucella", "suis", "1330", "C2987364#ent", "<e2>", "[", "WT", "]", "B.", "suis", ")", "on", "TNF-alpha", "production", "."], "h": {"id": "C1425923", "name": "C1425923#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [21, 22]}}
{"token": ["4-HEB", "also", "led", "to", "reactive", "oxygen", "species", "ROS", ")", "formation", "in", "melanoma", "cells", "exacerbated", "by", "C0015056#ent", "<e1>", "and", "1-bromoheptane", "whereas", "cyclosporin", "A", "C0040979#ent", "<e2>", "prevented", "it", "."], "h": {"id": "C0015056", "name": "C0015056#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [22, 23]}}
{"token": ["Reporter", "gene", "assays", "that", "the", "binding", "of", "C0035018#ent", "<e1>", "to", "the", "C1335875#ent", "<e2>", "site", "present", "in", "the", "Fc", "gammaR1", "gene", "to", "potent", "transactivation", "of", "this", "enhancer", "."], "h": {"id": "C0035018", "name": "C0035018#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335875", "name": "C1335875#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "the", "focal", "adhesion", "kinase", "FAK", "C1335596#ent", "<e1>", "whereas", "the", "FAK-related", "kinase", "C1335273#ent", "<e2>", "increases", "the", "basal", "levels", "apoptosis", "."], "h": {"id": "C1335596", "name": "C1335596#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335273", "name": "C1335273#ent", "pos": [14, 15]}}
{"token": ["The", "third", ",", "50th", "and", "97th", "centiles", "were", "calculated", "for", "the", "development", "of", "C0024902#ent", "<e1>", ",", "axillary", "and", "pubic", "hair", "and", "the", "shape", "of", "the", "C0019559#ent", "<e2>", "."], "h": {"id": "C0024902", "name": "C0024902#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019559", "name": "C0019559#ent", "pos": [25, 26]}}
{"token": ["Evidence", "is", "presented", "showing", "that", "idiosyncratic", "C0003211#ent", "<e1>", "drugs", "form", "prooxidant", "radicals", "when", "metabolised", "by", "C0031179#ent", "<e2>", "known", "to", "be", "present", "in", "these", "tissues", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031179", "name": "C0031179#ent", "pos": [15, 16]}}
{"token": ["Prostaglandin", "H2", "synthase", "EC", "1.14.99.1", ")", "is", "an", "integral", "membrane", "enzyme", "a", "cyclooxygenase", "site", "which", "is", "the", "target", "for", "the", "C0003211#ent", "<e1>", "and", "a", "spatially", "distinct", "C0031179#ent", "<e2>"], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0031179", "name": "C0031179#ent", "pos": [26, 27]}}
{"token": ["Defects", "of", "early", "steps", "intracellular", "cobalamin", "(", "C1848578#ent", "<e1>", ",", "cbl", "C/D", ")", "result", "in", "marked", "C2713546#ent", "<e2>", "of", "both", "cobalamin", "co-enzymes", "and", "homocystinuria", "combined", "with", "methylmalonic", "aciduria"], "h": {"id": "C1848578", "name": "C1848578#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2713546", "name": "C2713546#ent", "pos": [16, 17]}}
{"token": ["Both", "tryptophan", "mutations", "were", "combined", "to", "give", "a", "third", "mutant", "C0002085#ent", "<e1>", "that", "was", "found", "both", "unable", "to", "bind", "C0071665#ent", "<e2>", "and", "to", "suppress", "the", "lethality", "of", "a", "pfy1", "deletion", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0071665", "name": "C0071665#ent", "pos": [19, 20]}}
{"token": ["The", "Escherichia", "coli", "heat-stable", "enterotoxins", "STs", ")", "are", "small", "peptide", "toxins", "consisting", "of", "18", "(", "C1705352#ent", "<e1>", ")", "or", "19", "(", "STh", ")", "C3539946#ent", "<e2>"], "h": {"id": "C1705352", "name": "C1705352#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [23, 24]}}
{"token": ["The", "expression", "of", "c-fos", "and", "C0086661#ent", "<e1>", "mRNA", "in", "Balb/c", "3T3", "cells", "differentially", "regulated", "with", "respect", "to", "C3273324#ent", "<e2>", "cell", "cycle", "dependence"], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273324", "name": "C3273324#ent", "pos": [17, 18]}}
{"token": ["C0287935#ent", "<e1>", "CPD", ")", ",", "a", "C3265462#ent", "<e2>", "with", "CPE-like", "activity", ",", "is", "widely", "distributed", "in", "tissues", "and", "is", "present", "in", "the", "trans-Golgi", "network", "."], "h": {"id": "C0287935", "name": "C0287935#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3265462", "name": "C3265462#ent", "pos": [6, 7]}}
{"token": ["1", "The", "pharmacokinetics", "of", "C0016860#ent", "<e1>", "have", "been", "studied", "in", "thirteen", "patients", "with", "severe", "C0022661#ent", "<e2>", "using", "35", "S-frusemide", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [14, 15]}}
{"token": ["All", "these", "C0127400#ent", "<e1>", "could", "alter", "the", "proliferation", "and", "C0948245#ent", "<e2>", "interleukin", "(", "IL", ")", "1beta", ",", "IL6", ",", "IL8", ",", "tumor", "necrosis", "factor", "alpha", "for", "a", "minority", "of", "patients", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0948245", "name": "C0948245#ent", "pos": [9, 10]}}
{"token": ["Coagulation", "studies", "performed", "on", "16", "children", "with", "C0036685#ent", "<e1>", "the", "complications", "of", "septic", "shock", "C0023895#ent", "<e2>", "malnutrition", ",", "or", "laboratory", "evidence", "classic", "disseminated", "intravascular", "coagulation", "DIC", ")", "."], "h": {"id": "C0036685", "name": "C0036685#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [14, 15]}}
{"token": ["OP-41483", ",", "a", "derivative", "of", "prostacyclin", "which", "is", "about", "five", "times", "more", "active", "than", "PGE1", "in", "inhibiting", "platelet", "aggregation", "and", "other", "anti-platelet", "drugs", "for", "C0040207#ent", "<e1>", "were", "not", "effective", "in", "preventing", "C0268731#ent", "<e2>"], "h": {"id": "C0040207", "name": "C0040207#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [31, 32]}}
{"token": ["Further", "addition", "of", "C0032143#ent", "<e1>", "to", "the", "22-h", "treated", "cells", "not", "cause", "an", "increase", "in", "C1416746#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416746", "name": "C1416746#ent", "pos": [15, 16]}}
{"token": ["C0069197#ent", "<e1>", "suppression", "and", "hypermethylation", "at", "the", "CpG", "island", "the", "C0069197#ent", "<e1>", "promoter", "occurred", "6", "days", "after", "C1420204#ent", "<e1>", "treatment", ",", "indicating", "that", "epigenetic", "modifications", "C0069197#ent", "<e1>", "might", "be", "an", "early", "event", "tumorigenesis", "."], "h": {"id": "C1420204", "name": "C1420204#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0069197", "name": "C0069197#ent", "pos": [0, 1]}}
{"token": ["We", "aimed", "to", "objectively", "determine", "whether", "C0771774#ent", "<e1>", "as", "an", "alpha(1)-blocker", "was", "effective", "in", "patients", "who", "had", "C0162301#ent", "<e2>", "located", "in", "the", "lower", "part", "of", "the", "ureter", "."], "h": {"id": "C0771774", "name": "C0771774#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162301", "name": "C0162301#ent", "pos": [17, 18]}}
{"token": ["Immunohistochemistry", "was", "used", "to", "evaluate", "C0699919#ent", "<e1>", "overexpression", "in", "cancer", "cells", "to", "visualize", "microvessels", "with", "antibodies", "against", "C1336938#ent", "<e2>"], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [17, 18]}}
{"token": ["The", "involvement", "of", "caspases", "in", "the", "IR", "response", "demonstrated", "by", "using", "C0383779#ent", "<e1>", "and", "zDEVD-FMK", "caspase", "inhibitors", ";", "both", "apoptosis", "and", "C0019693#ent", "<e2>", "expression", "were", "inhibited", "to", "similar", "extent", "."], "h": {"id": "C0383779", "name": "C0383779#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [21, 22]}}
{"token": ["In", "one", "study", "C0400807#ent", "<e1>", "prophylaxis", "with", "C0028978#ent", "<e2>", "more", "effective", "than", "prophylaxis", "with", "intravenous", "ranitidine", "."], "h": {"id": "C0400807", "name": "C0400807#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [7, 8]}}
{"token": ["In", "critically", "ill", "patients", "with", "bleeding", "peptic", "ulcer", "which", "developed", "despite", "prophylactic", "measures", "for", "C0400807#ent", "<e1>", "bleeding", "stopped", "in", "16", "out", "of", "19", "patients", "treated", "with", "C0028978#ent", "<e2>", "given", "as", "a", "40-mg", "i.v", "."], "h": {"id": "C0400807", "name": "C0400807#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [26, 27]}}
{"token": ["C0058031#ent", "<e1>", "appears", "to", "be", "bound", "to", "an", "alpha", "2-adrenergic", "receptor", "C0724441#ent", "<e2>", "had", "a", "much", "greater", "ability", "to", "compete", "for", "C0058031#ent", "<e1>", "binding", "sites", "than", "did", "prazosin", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0058031", "name": "C0058031#ent", "pos": [0, 1]}}
{"token": ["Glutathione", "S-transferase", "pull-down", "co-immunoprecipitation", "assays", "that", "C3889381#ent", "<e1>", "interacts", "specifically", "with", "C1709442#ent", "<e2>", "under", "both", "in", "vitro", "in", "vivo", "conditions", "."], "h": {"id": "C3889381", "name": "C3889381#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1709442", "name": "C1709442#ent", "pos": [11, 12]}}
{"token": ["C4082489#ent", "<e1>", "is", "reported", "to", "act", "as", "either", "an", "C0030946#ent", "<e2>", "or", "an", "exopeptidase", ",", "exhibiting", "species", "differences", "in", "these", "functions", "."], "h": {"id": "C4082489", "name": "C4082489#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [9, 10]}}
{"token": ["Both", "viral", "infections", "dysregulated", "cytokine", "synthesis", "been", "implicated", "in", "the", "pathogenesis", "of", "C2919502#ent", "<e1>", "IgAN", ")", "and", "C2721603#ent", "<e2>", "HSP", ")", "."], "h": {"id": "C2919502", "name": "C2919502#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2721603", "name": "C2721603#ent", "pos": [17, 18]}}
{"token": ["Activation", "of", "either", "the", "calcineurin", "or", "the", "C4082284#ent", "<e1>", "ERK1/2", ")", "pathway", "increases", "the", "percentage", "of", "C0225326#ent", "<e2>", "in", "vivo", "that", "both", "pathways", "can", "regulate", "fibre", "phenotypes", "in", "skeletal", "muscle"], "h": {"id": "C4082284", "name": "C4082284#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [16, 17]}}
{"token": ["The", "MCB", ",", "ZB", "and", "CB", "resembled", "those", "in", "C0268274#ent", "<e1>", "GMG", ")", ",", "and", "the", "BTS", "that", "in", "C0270724#ent", "<e2>", "INAD", ")", "."], "h": {"id": "C0268274", "name": "C0268274#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0270724", "name": "C0270724#ent", "pos": [19, 20]}}
{"token": ["We", "conclude", "that", "NPPV", "is", "a", "feasible", "and", "appropriate", "treatment", "for", "C0022660#ent", "<e1>", "occurring", "as", "a", "result", "of", "a", "C1419818#ent", "<e2>", "infection", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1419818", "name": "C1419818#ent", "pos": [19, 20]}}
{"token": ["The", "C4019039#ent", "<e1>", "resolved", "only", "after", "the", "administration", "of", "C0025853#ent", "<e2>", "."], "h": {"id": "C4019039", "name": "C4019039#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0025853", "name": "C0025853#ent", "pos": [9, 10]}}
{"token": ["Phagocytic", "capacity", "(", "C1418724#ent", "<e1>", ")", "was", "significantly", "higher", "in", "the", "C1413108#ent", "<e2>", "group", "(", "p<0.001", ")", "."], "h": {"id": "C1418724", "name": "C1418724#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413108", "name": "C1413108#ent", "pos": [11, 12]}}
{"token": ["Cl-", "and", "K+", "channels", "recorded", "simultaneously", "from", "two", "patches", "(", "4", "%", "of", "patches", ")", "in", "the", "C3272518#ent", "<e1>", "and", "from", "none", "of", "the", "patches", "in", "the", "C0751951#ent", "<e2>", "."], "h": {"id": "C3272518", "name": "C3272518#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0751951", "name": "C0751951#ent", "pos": [27, 28]}}
{"token": ["The", "results", "suggested", "that", "C1136254#ent", "<e1>", "cellular", "immunity", "occur", "as", "a", "phenomenon", "independent", "of", "C1832586#ent", "<e2>", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1832586", "name": "C1832586#ent", "pos": [14, 15]}}
{"token": ["Cells", "were", "characterized", "by", "heterogeneous", "expression", "of", "C0210657#ent", "<e1>", "determinants", ",", "including", "thymidylate", "synthase", "C0040963#ent", "<e2>", ")", "and", "dihydrofolate", "reductase", "DHFR", ")", ",", "and", "mutations", "potentially", "affecting", "chemosensitivity", "."], "h": {"id": "C0210657", "name": "C0210657#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040963", "name": "C0040963#ent", "pos": [14, 15]}}
{"token": ["C0027121#ent", "<e1>", "ranging", "from", "the", "vasculitides", "(", "C0039263#ent", "<e2>", "giant", "cell", "arteritis", "and", "polyarteritis", "nodosa", "to", "atherosclerosis", ",", "display", "remarkable", "target", "tissue", "tropisms", "for", "selected", "vascular", "beds"], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039263", "name": "C0039263#ent", "pos": [7, 8]}}
{"token": ["We", "find", "that", "purified", "mouse", "NBD1", ",", "human", "NBD1", ",", "and", "human", "NBD2", "function", "as", "C0001497#ent", "<e1>", "not", "as", "C0001473#ent", "<e2>", "."], "h": {"id": "C0001497", "name": "C0001497#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [19, 20]}}
{"token": ["When", "microtubules", "were", "depolymerized", "with", "C0028247#ent", "<e1>", ",", "this", "accumulation", "disappeared", "and", "C1424489#ent", "<e2>", "was", "confined", "to", "the", "ER", "."], "h": {"id": "C0028247", "name": "C0028247#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424489", "name": "C1424489#ent", "pos": [12, 13]}}
{"token": ["Two", "inherited", "C0029132#ent", "<e1>", ",", "Charcot-Marie-Tooth", "type", "2A", "autosomal", "dominant", "optic", "atrophy", "are", "caused", "by", "mutations", "in", "C3816215#ent", "<e2>", "OPA1", ",", "suggesting", "that", "proper", "regulation", "of", "mitochondrial", "dynamics", "is", "particularly", "vital", "to", "neurons", "."], "h": {"id": "C0029132", "name": "C0029132#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3816215", "name": "C3816215#ent", "pos": [17, 18]}}
{"token": ["Consistent", "with", "data", ",", "the", "C1419771#ent", "<e1>", "a", "strong", "repressor", "of", "the", "promoter", "of", "the", "C1511576#ent", "<e2>", "p21(CIP1", ")", ",", "while", "RUNX2Delta8", "was", "a", "competitive", "inhibitor", "of", "RUNX2", "and", "exhibited", "weak", "repression", "activity"], "h": {"id": "C1419771", "name": "C1419771#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1511576", "name": "C1511576#ent", "pos": [15, 16]}}
{"token": ["Our", "results", "support", "a", "role", "for", "phospholipase", "D-derived", "products", "modulating", "the", "activation", "of", "C1333201#ent", "<e1>", ",", "further", "supporting", "the", "idea", "of", "cross-talk", "among", "various", "C0031671#ent", "<e2>", "."], "h": {"id": "C1333201", "name": "C1333201#ent", "pos": [13, 14]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [24, 25]}}
{"token": ["To", "analyze", "the", "correlation", "between", "C0751937#ent", "<e1>", "the", "morphology", "of", "nasal", "cavity", "C0948780#ent", "<e2>", "CRS", ")", "."], "h": {"id": "C0751937", "name": "C0751937#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0948780", "name": "C0948780#ent", "pos": [12, 13]}}
{"token": ["C0012010#ent", "<e1>", "is", "metabolized", "by", "C0960580#ent", "<e2>", "and", "CYP3A4", "in", "the", "liver", "."], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [0, 1]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C0960580", "name": "C0960580#ent", "pos": [5, 6]}}
{"token": ["In", "an", "African", "American", "in", "which", "autosomal", "recessive", "C1567741#ent", "<e1>", "rarely", "seen", ",", "complete", "sequencing", "of", "the", "C1332774#ent", "<e2>", "and", "COL4A4", "genes", "be", "necessary", "to", "identify", "the", "underlying", "mutation", "and", "confirm", "the", "diagnosis", "."], "h": {"id": "C1567741", "name": "C1567741#ent", "pos": [8, 9]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332774", "name": "C1332774#ent", "pos": [17, 18]}}
{"token": ["C0617763#ent", "<e1>", "selectively", "increased", "the", "C1414910#ent", "<e2>", "subunit", "expression", "in", "amygdala", "of", "mouse", "brain"], "h": {"id": "C0617763", "name": "C0617763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414910", "name": "C1414910#ent", "pos": [5, 6]}}
{"token": ["While", "most", "patients", "with", "C0024535#ent", "<e1>", "cured", "with", "the", "standard", "chloroquine", "and", "C0033126#ent", "<e2>", "regimen", ",", "a", "higher", "dosage", "was", "required", "for", "one", "case", "acquired", "in", "Papua", "New", "Guinea"], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0033126", "name": "C0033126#ent", "pos": [12, 13]}}
{"token": ["After", "his", "illness", "was", "diagnosed", "as", "C0024535#ent", "<e1>", "he", "was", "managed", "with", "hydroxychloroquine", "and", "then", "C0033126#ent", "<e2>", "(", "C0033126#ent", "<e2>", "base", "15", "mg/day", "for", "14", "days", ")", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0033126", "name": "C0033126#ent", "pos": [15, 16]}}
{"token": ["Effects", "of", "C0002934#ent", "<e1>", "procaine", ",", "lidocaine", ",", "C0033124#ent", "<e2>", ",", "mepivacaine", "and", "bupivacaine", ")", "on", "AV", "conductivity", "studied", "using", "a", "direct", "perfusion", "technique", "of", "the", "canine", "AV", "node", "artery", "in", "situ"], "h": {"id": "C0002934", "name": "C0002934#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033124", "name": "C0033124#ent", "pos": [8, 9]}}
{"token": ["C0025845#ent", "<e1>", "was", "ineffective", "in", "antagonising", "responses", "to", "histamine", "and", "related", "C2987634#ent", "<e2>", "as", "was", "mepyramine", "."], "h": {"id": "C0025845", "name": "C0025845#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [11, 12]}}
{"token": ["While", "considering", "related", "mechanisms", ",", "we", "noted", "higher", "levels", "of", "TNF-alpha", ",", "an", "up-regulator", "of", "C1332823#ent", "<e1>", ",", "and", "of", "VSMC", "proliferation", "in", "the", "injured", "C1416746#ent", "<e2>"], "h": {"id": "C1332823", "name": "C1332823#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1416746", "name": "C1416746#ent", "pos": [25, 26]}}
{"token": ["No", "significant", "influence", "was", "found", "on", "the", "time", "of", "ischaemia", ",", "previous", "C0018799#ent", "<e1>", "previous", "treatment", "with", "C1448410#ent", "<e2>", ",", "clinical", "condition", "etc.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1448410", "name": "C1448410#ent", "pos": [17, 18]}}
{"token": ["Our", "C1416596#ent", "<e1>", "is", "to", "fully", "identify", "the", "impact", "of", "riluzole", "in", "C1704945#ent", "<e2>", "treatment", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [12, 13]}}
{"token": ["While", "DAFs", "and", "the", "structurally", "related", "diaminorhodamines", "(", "C1413909#ent", "<e1>", ")", "both", "react", "with", "NO", "and", "C2348308#ent", "<e2>", ",", "they", "do", "so", "to", "different", "extents", "."], "h": {"id": "C1413909", "name": "C1413909#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2348308", "name": "C2348308#ent", "pos": [16, 17]}}
{"token": ["Thiolated", "additives", "based", "on", "PVA", "and", "other", "substrates", "were", "previously", "presented", "as", "effective", "means", "of", "improving", "the", "strength", "and", "toughness", "of", "compression", "molded", "native", "C3495801#ent", "<e1>", "bars", "via", "C0072354#ent", "<e2>"], "h": {"id": "C3495801", "name": "C3495801#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0072354", "name": "C0072354#ent", "pos": [28, 29]}}
{"token": ["C1332691#ent", "<e1>", "induced", "phosphorylation/activation", "of", "C1414805#ent", "<e2>", ",", "p70", "S6K1", ",", "and", "ribosomal", "protein", "S6"], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414805", "name": "C1414805#ent", "pos": [5, 6]}}
{"token": ["Angiostatin", ",", "a", "C1367553#ent", "<e1>", "3", "-", "4", "N-terminal", "kringle", "domains", "is", "a", "potent", "inhibitor", "of", "C1366571#ent", "<e2>", "angiogenesis", ",", "but", "its", "mechanism", "of", "action", "is", "unclear", "."], "h": {"id": "C1367553", "name": "C1367553#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1366571", "name": "C1366571#ent", "pos": [16, 17]}}
{"token": ["However", ",", "acute", "effects", "C0058310#ent", "<e1>", "on", "mRNA", "encoding", "C3538859#ent", "<e2>", "and", "StAR", "were", "observed", "when", "concentrations", "of", "mRNA", "encoding", "SF-1", "were", "not", "influenced", "."], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3538859", "name": "C3538859#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "the", "mRNA", "levels", "of", "C1413784#ent", "<e1>", ",", "GATA5", ",", "VEGF", ",", "GATA1", "and", "C1414993#ent", "<e2>", "genes", "in", "defective", "embryos", "were", "significantly", "reduced", "by", "rtEa4-peptide", "."], "h": {"id": "C1413784", "name": "C1413784#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414993", "name": "C1414993#ent", "pos": [15, 16]}}
{"token": ["The", "following", "reference", "drugs", "tested", "for", "comparison", ":", "prolyl-leucylglycine", "amide", "MIF", ")", ",", "atropine", ",", "haloperidol", ",", "C0005578#ent", "<e1>", ",", "ethopropazine", ",", "trihexyphenidyl", ",", "C0066139#ent", "<e2>", "and", "clonazepam", "."], "h": {"id": "C0005578", "name": "C0005578#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0066139", "name": "C0066139#ent", "pos": [24, 25]}}
{"token": ["Posttranslational", "processing", "preproendothelin", "in", "endothelial", "cells", "rise", "to", "endothelin", ",", "a", "21", "C1305923#ent", "<e1>", "is", "a", "potent", "C0042397#ent", "<e2>", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [17, 18]}}
{"token": ["Similarly", ",", "caffeine", ",", "nicotine", ",", "C0936073#ent", "<e1>", ",", "salicylic", "acid", "antipyrine", ",", "barbital", ",", "and", "C0022209#ent", "<e2>", "enter", "the", "uterine", "secretion", "penetrate", "the", "preimplantation", "blastocyst", "mice", ",", "rats", "and", "rabbits", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0022209", "name": "C0022209#ent", "pos": [16, 17]}}
{"token": ["The", "electrocardiogram", "of", "27", "patients", "with", "C0007193#ent", "<e1>", "CMC", ")", ",", "15", "with", "obstructive", "(", "C1413857#ent", "<e2>", ")", "and", "13", "with", "hypertrophic", "without", "obstruction", "(", "CMH", ")", "have", "been", "studied", "."], "h": {"id": "C0007193", "name": "C0007193#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413857", "name": "C1413857#ent", "pos": [15, 16]}}
{"token": ["CR", "and", "C3811118#ent", "<e1>", ",", "which", "were", "each", "an", "ingredient", "of", "C1417945#ent", "<e2>", ",", "might", "contain", "some", "components", "with", "strong", "antibacterial", "activity", "P.", "acnes", "."], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417945", "name": "C1417945#ent", "pos": [11, 12]}}
{"token": ["Deficiency", "of", "C1413076#ent", "<e1>", "CACT", ")", "is", "an", "C3899988#ent", "<e2>", "the", "carnitine", "cycle", "in", "the", "inability", "to", "transfer", "fatty", "acids", "the", "inner", "mitochondrial", "membrane"], "h": {"id": "C1413076", "name": "C1413076#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [8, 9]}}
{"token": ["The", "C0003158#ent", "<e1>", "efficacy", "of", "C0001911#ent", "<e2>", "intra-ruminal", "slow-release", "capsules", "(", "SRC", ")", "and", "C0001911#ent", "<e2>", "drench", "against", "field", "strains", "5", "genera", "of", "nematode", "parasites", "of", "sheep", ",", "where", "compared", "."], "h": {"id": "C0003158", "name": "C0003158#ent", "pos": [1, 2]}, "relation": "therapeutic_class_of", "t": {"id": "C0001911", "name": "C0001911#ent", "pos": [5, 6]}}
{"token": ["C0019643#ent", "<e1>", "HDAC", ")", "inhibitors", "such", "as", "suberoylanilide", "hydroxamic", "acid", "C0672708#ent", "<e2>", ")", "are", "known", "to", "induce", "apoptosis", "of", "cancer", "cells", "reduce", "production", "of", "proinflammatory", "cytokines", "by", "nonmalignant", "cells"], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [0, 1]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0672708", "name": "C0672708#ent", "pos": [10, 11]}}
{"token": ["To", "investigate", "the", "specific", "phenotype", "of", "hyperplastic", "nodules", "C3538884#ent", "<e1>", ")", "in", "rat", "C0023899#ent", "<e2>", ",", "we", "produced", "a", "monoclonal", "antibody", "HAM-6", ")", "."], "h": {"id": "C3538884", "name": "C3538884#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "a", "case", "of", "hypopituitarism", "and", "C0020514#ent", "<e1>", "in", "a", "patient", "with", "pituitary", "metastases", "a", "colon", "carcinoma", "C2350529#ent", "<e2>", "."], "h": {"id": "C0020514", "name": "C0020514#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2350529", "name": "C2350529#ent", "pos": [18, 19]}}
{"token": ["Linkage", "analysis", "performed", "on", "49", "C1413138#ent", "<e1>", "families", "with", "autosomal", "dominant", "C3149841#ent", "<e2>", "via", "the", "Nephrology", "Department", "related", "nephrology", "centers"], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [11, 12]}}
{"token": ["rBAT", "heterodimerizes", "with", "b(0,+)AT", "(", "C1420228#ent", "<e1>", ")", "constituting", "the", "C2986633#ent", "<e2>", ",", "the", "main", "system", "responsible", "for", "the", "apical", "reabsorption", "cystine", "in", "kidney", "."], "h": {"id": "C1420228", "name": "C1420228#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2986633", "name": "C2986633#ent", "pos": [10, 11]}}
{"token": ["These", "observations", "are", "interpreted", "as", "being", "the", "result", "of", "a", "rapid", "turnover", "of", "ATP", "stimulating", "C0010287#ent", "<e1>", "production", "by", "the", "mitochondrial", "isozyme", "creatine", "kinase", "ATP", ":", "creatine", "N-phosphotransferase", "C3714613#ent", "<e2>", "."], "h": {"id": "C0010287", "name": "C0010287#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3714613", "name": "C3714613#ent", "pos": [28, 29]}}
{"token": ["A", "78-year-old", "woman", "developed", "fatal", "C0014118#ent", "<e1>", "of", "her", "prosthetic", "aortic", "valve", "caused", "by", "C1456246#ent", "<e2>", "and", "associated", "with", "ovarian", "carcinoma"], "h": {"id": "C0014118", "name": "C0014118#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1456246", "name": "C1456246#ent", "pos": [14, 15]}}
{"token": ["The", "C0398349#ent", "<e1>", "DIOS", ")", "is", "a", "current", "complication", "in", "patients", "with", "C0010674#ent", "<e2>"], "h": {"id": "C0398349", "name": "C0398349#ent", "pos": [1, 2]}, "relation": "manifestation_of", "t": {"id": "C0010674", "name": "C0010674#ent", "pos": [12, 13]}}
{"token": ["The", "modulation", "of", "the", "C1332675#ent", "<e1>", "by", "fear", "depends", "critically", "on", "the", "C0002707#ent", "<e2>", "."], "h": {"id": "C1332675", "name": "C1332675#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002707", "name": "C0002707#ent", "pos": [12, 13]}}
{"token": ["A", "45-year-old", "woman", "with", "an", "acquired", "multifocal", "neurologic", "syndrome", ",", "including", "chorea", ",", "dystonia", ",", "cerebellar", "dysfunction", "C0751059#ent", "<e1>", "and", "pure", "C0151313#ent", "<e2>", "was", "found", "at", "autopsy", "to", "have", "oat", "cell", "carcinoma"], "h": {"id": "C0751059", "name": "C0751059#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [21, 22]}}
{"token": ["The", "relationship", "between", "a", "C0020554#ent", "<e1>", "suxamethonium", "and", "C0027868#ent", "<e2>", "including", "myotonic", "disorders", "the", "malignant", "hyperpyrexia", "myopathy", "is", "considered", "."], "h": {"id": "C0020554", "name": "C0020554#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [8, 9]}}
{"token": ["Both", "proteins", "contain", "two", "putative", "zinc", "fingers", "are", "identical", "throughout", "the", "DNA", "binding", "region", "and", "deletion", "of", "both", "C2827376#ent", "<e1>", "and", "GIS1", "is", "required", "to", "fully", "derepress", "C0242988#ent", "<e2>", "in", "the", "absence", "of", "damage", "."], "h": {"id": "C2827376", "name": "C2827376#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0242988", "name": "C0242988#ent", "pos": [27, 28]}}
{"token": ["Yohimbine-induced", "enhancement", "of", "sympathetic", "tone", "patients", "with", "C1744687#ent", "<e1>", "improves", "orthostatic", "tolerance", "raises", "the", "possibility", "that", "this", "C0013227#ent", "<e2>", "may", "be", "a", "useful", "agent", "in", "the", "treatment", "of", "C1744687#ent", "<e1>", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1744687", "name": "C1744687#ent", "pos": [7, 8]}}
{"token": ["The", "variable", "manifestations", "of", "respiratory", "problems", "finishing", "pigs", "have", "led", "to", "the", "concept", "of", "a", "multiple-factor", "aetiology", "for", "C0035242#ent", "<e1>", "in", "particular", "for", "C0276046#ent", "<e2>"], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0276046", "name": "C0276046#ent", "pos": [23, 24]}}
{"token": ["We", "have", "identified", "miss-sense", "mutations", "C0022564#ent", "<e1>", "8", "in", "a", "subset", "of", "patients", "with", "C0010346#ent", "<e2>", "Crohn", "disease", "ulcerative", "colitis", "."], "h": {"id": "C0022564", "name": "C0022564#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [14, 15]}}
{"token": ["The", "scaffold", "protein", "MEK1", "(", "mitogen-activated", "protein", "kinase", "ERK", "kinase", "1", ")", "partner", "(", "C1425030#ent", "<e1>", ")", "is", "localized", "to", "late", "endosomes", "by", "the", "C1332163#ent", "<e2>"], "h": {"id": "C1425030", "name": "C1425030#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332163", "name": "C1332163#ent", "pos": [24, 25]}}
{"token": ["Those", "describing", "the", "use", "of", "C0008196#ent", "<e1>", "for", "oral", "decontamination", "reporting", "the", "incidence", "of", "C0149725#ent", "<e2>", "as", "a", "study", "outcome", "included", "in", "the", "meta-analysis", "."], "h": {"id": "C0008196", "name": "C0008196#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149725", "name": "C0149725#ent", "pos": [14, 15]}}
{"token": ["Enterokinase", "(", "C3816181#ent", "<e1>", "is", "a", "C0072402#ent", "<e2>", "a", "specific", "digest", "sequence", "(Asp)4-Lys", "in", "the", "duodenum", "."], "h": {"id": "C3816181", "name": "C3816181#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [6, 7]}}
{"token": ["Apoptosis", "appeared", "after", "the", "onset", "of", "C0054757#ent", "<e1>", "and", "completion", "of", "virus", "replication", "and", "could", "be", "prevented", "by", "C1704467#ent", "<e2>", "expression", "."], "h": {"id": "C0054757", "name": "C0054757#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [18, 19]}}
{"token": ["The", "C0027203#ent", "<e1>", "also", "showed", "approximately", "35", "%", "similarity", "with", "C1418514#ent", "<e2>", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418514", "name": "C1418514#ent", "pos": [10, 11]}}
{"token": ["Normal", "CSEP", "showed", "typical", "triphasic", "potential", "starting", "with", "an", "initial", "C1424701#ent", "<e1>", ",", "followed", "by", "N13", "and", "a", "final", "positivity", ",", "C3273601#ent", "<e2>", "."], "h": {"id": "C1424701", "name": "C1424701#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273601", "name": "C3273601#ent", "pos": [21, 22]}}
{"token": ["Of", "those", "tested", ",", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "induced", "phosphorylation", "of", "C4042483#ent", "<e1>", "blunted", "cytochrome", "c", "during", "chemotherapy", "or", "C1144558#ent", "<e2>", "treatment", "of", "ALL", "cells"], "h": {"id": "C4042483", "name": "C4042483#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1144558", "name": "C1144558#ent", "pos": [21, 22]}}
{"token": ["To", "study", "whether", "zearalenone", "(", "ZEA", ")", ",", "a", "fungal", "C2936882#ent", "<e1>", ",", "can", "transcriptionally", "up-regulate", "the", "expression", "of", "C3714798#ent", "<e2>", "CYP3A4", ")", "transcription", "by", "activating", "human", "steroid", "hormone", "xenobiotic", "receptor", "SXR", ")", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "we", "addressed", "the", "C1413240#ent", "<e1>", "potential", "of", "galectin-1", "(", "C0060947#ent", "<e2>", ")", "in", "a", "panel", "of", "carcinoma", "cell", "lines"], "h": {"id": "C1413240", "name": "C1413240#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0060947", "name": "C0060947#ent", "pos": [11, 12]}}
{"token": ["Transcription", "of", "the", "P.", "gingivalis", "rubrerythrin", "gene", "is", "induced", "above", "its", "C0669365#ent", "<e1>", "anaerobic", "level", "in", "response", "to", "C0599874#ent", "<e2>", "or", "hydrogen", "peroxide", "exposures", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0599874", "name": "C0599874#ent", "pos": [18, 19]}}
{"token": ["C1418552#ent", "<e1>", "inhibits", "both", "tumor", "cell", "C1367553#ent", "<e2>", "destruction", "of", "extracellular", "matrix"], "h": {"id": "C1418552", "name": "C1418552#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [6, 7]}}
{"token": ["Hereditary", "spastic", "paraplegia", "HSP", ")", "is", "a", "C1285162#ent", "<e1>", "the", "motor", "system", "defined", "by", "progressive", "C3714552#ent", "<e2>", "and", "spasticity", "of", "the", "lower", "limbs"], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [15, 16]}}
{"token": ["Amyotrophic", "lateral", "sclerosis", "ALS", ")", ",", "or", "motor", "neuron", "disease", "MND", ")", "as", "it", "is", "usually", "termed", "in", "the", "United", "Kingdom", "is", "a", "fatal", "C1285162#ent", "<e1>", "in", "progressive", "C3714552#ent", "<e2>", "and", "wasting", "of", "voluntary", "muscles", "."], "h": {"id": "C1285162", "name": "C1285162#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C3714552", "name": "C3714552#ent", "pos": [28, 29]}}
{"token": ["Therapies", "for", "C0011432#ent", "<e1>", "both", "C0035064#ent", "<e2>", "that", "obstruct", "the", "dentinal", "tubules", "C0035064#ent", "<e2>", "that", "can", "decrease", "the", "excitability", "of", "the", "intradental", "nerves", "."], "h": {"id": "C0011432", "name": "C0011432#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}}
{"token": ["The", "use", "of", "plasma-derived", "factor", "products", "to", "treat", "hemophilia", "A", "hemophilia", "B", "and", "von", "Willebrand", "disease", "C1264041#ent", "<e1>", ")", "has", "changed", "since", "the", "start", "of", "the", "C3854222#ent", "<e2>", "HIV", ")", "epidemic", "."], "h": {"id": "C1264041", "name": "C1264041#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3854222", "name": "C3854222#ent", "pos": [26, 27]}}
{"token": ["Other", "clones", "shared", "sequence", "homology", "with", "C1417679#ent", "<e1>", "encoding", "ribosomal", "and", "mitochondrial", "proteins", "the", "translation", "initiation", "factor", "C1414356#ent", "<e2>", "and", "the", "bovine", "pancreatic", "thread", "protein"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414356", "name": "C1414356#ent", "pos": [17, 18]}}
{"token": ["Causal", "chains", "leading", "to", "two", "illnesses", ",", "C0155668#ent", "<e1>", "depression", ",", "were", "elicited", "from", "participant", "groups", ":", "registered", "nurses", "C1850106#ent", "<e2>", ")", ",", "energy", "healers", "RN", "energy", "healers", ",", "and", "undergraduates", "."], "h": {"id": "C0155668", "name": "C0155668#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1850106", "name": "C1850106#ent", "pos": [19, 20]}}
{"token": ["Here", "we", "report", "that", "SAG", ",", "an", "C1418881#ent", "<e1>", "Ring-H2", "finger", "motif", "is", "a", "cellular", "partner", "with", "the", "beta", "subunit", "C1707154#ent", "<e2>", "."], "h": {"id": "C1418881", "name": "C1418881#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1707154", "name": "C1707154#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "the", "metabolism", "of", "C4284038#ent", "<e1>", "by", "expressed", "human", "C3714798#ent", "<e2>", "specific", "for", "keto", "alcohol", "formation"], "h": {"id": "C4284038", "name": "C4284038#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3714798", "name": "C3714798#ent", "pos": [11, 12]}}
{"token": ["Examination", "disclosed", "a", "C3810629#ent", "<e1>", "male", "with", "frontal", "alopecia", "C0235394#ent", "<e2>", "facial", "and", "proximal", "limb", "muscles", "."], "h": {"id": "C3810629", "name": "C3810629#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235394", "name": "C0235394#ent", "pos": [9, 10]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "examine", "the", "association", "between", "common", "polymorphisms", "of", "the", "adiponectin", "gene", "C1859372#ent", "<e1>", ")", "and", "carotid", "atherosclerosis", "patients", "with", "C0011860#ent", "<e2>"], "h": {"id": "C1859372", "name": "C1859372#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [25, 26]}}
{"token": ["C0338902#ent", "<e1>", "the", "most", "common", "form", "of", "C1969807#ent", "<e2>"], "h": {"id": "C0338902", "name": "C0338902#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1969807", "name": "C1969807#ent", "pos": [7, 8]}}
{"token": ["The", "authors", "present", "a", "10-year-old", "boy", "chronically", "treated", "with", "C0065374#ent", "<e1>", ",", "an", "angiotensin", "converting", "enzyme", "inhibitor", "to", "C0020538#ent", "<e2>", "developed", "hypotension", "following", "the", "addition", "of", "tizanidine", ",", "an", "alpha-2", "agonist", "for", "the", "treatment", "of", "spasticity", "."], "h": {"id": "C0065374", "name": "C0065374#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}}
{"token": ["These", "inhibitors", "were", "C0002641#ent", "<e1>", ",", "thioridazine", ",", "thiothixene", ",", "C0040979#ent", "<e2>", ",", "tetrandrine", ",", "tannic", "acid", "polyphenolic", "extracts", "of", "tea", ",", "grape", "seed", "pine", "bark"], "h": {"id": "C0002641", "name": "C0002641#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0040979", "name": "C0040979#ent", "pos": [10, 11]}}
{"token": ["We", "have", "investigated", "whether", "C3540800#ent", "<e1>", "has", "effects", "on", "transcription", "factor", "binding", "consensus", "DNA", "sequences", "AP-1", "and", "cyclic", "AMP-responsive", "element", "C1511573#ent", "<e2>", ")", "in", "cultured", "rat", "neurons", "and", "in", "vivo"], "h": {"id": "C3540800", "name": "C3540800#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [20, 21]}}
{"token": ["In", "the", "stroma", ",", "there", "was", "a", "gain", "of", "C1538842#ent", "<e1>", "(", "P", "<", ".05", ")", "and", "loss", "of", "C2987024#ent", "<e2>", "(", "P", "<", ".0001", ")", "."], "h": {"id": "C1538842", "name": "C1538842#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2987024", "name": "C2987024#ent", "pos": [19, 20]}}
{"token": ["Pretreatment", "with", "C0591120#ent", "<e1>", "did", "not", "prolong", "the", "survival", "rate", "probably", "because", "of", "an", "C0282193#ent", "<e2>", "of", "the", "reticuloendothelial", "system", "fibrin", "degradation", "products", "."], "h": {"id": "C0591120", "name": "C0591120#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0282193", "name": "C0282193#ent", "pos": [14, 15]}}
{"token": ["In", "conclusion", ",", "C0039082#ent", "<e1>", "patients", "had", "better", "exercise", "performance", "than", "C1504769#ent", "<e2>", "patients", ",", "but", "less", "ED", "and", "similar", "workload", "when", "compared", "with", "control", "subjects"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1504769", "name": "C1504769#ent", "pos": [11, 12]}}
{"token": ["This", "inactivation", "was", "associated", "with", "deacetylation", "and", "lysine", "9", "trimethylation", "of", "C3829685#ent", "<e1>", "an", "impaired", "binding", "of", "Sp1", "at", "the", "C1882525#ent", "<e2>", "promoter", "."], "h": {"id": "C3829685", "name": "C3829685#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1882525", "name": "C1882525#ent", "pos": [20, 21]}}
{"token": ["C2936592#ent", "<e1>", "constitute", "a", "family", "of", "C3540772#ent", "<e2>", "which", "are", "implicated", "in", "a", "variety", "of", "inflammatory", "disorders", "asthma", "."], "h": {"id": "C2936592", "name": "C2936592#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [6, 7]}}
{"token": ["Treatment", "varies", "from", "observation", "or", "C0003451#ent", "<e1>", "for", "varicella", "to", "cryosurgery", "and", "C0165032#ent", "<e2>", "warts", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0165032", "name": "C0165032#ent", "pos": [12, 13]}}
{"token": ["Each", "of", "these", "C0035064#ent", "<e1>", "effectively", "inhibited", "C0001622#ent", "<e2>", "stimulated", "by", "the", "peptides", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [7, 8]}}
{"token": ["This", "phosphorylation", "was", "suppressed", "by", "the", "C3539645#ent", "<e1>", "inhibitors", ",", "although", "C1335877#ent", "<e2>", "activation", "was", "unaffected", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335877", "name": "C1335877#ent", "pos": [11, 12]}}
{"token": ["Immulectin-2", ",", "C0146224#ent", "<e1>", "and", "PAP-1", "in", "hemolymph", "bound", "to", "the", "immobilized", "recombinant", "C3641725#ent", "<e2>", "SPH-1", ",", "indicating", "that", "a", "complex", "containing", "these", "proteins", "may", "exist", "in", "hemolymph", "."], "h": {"id": "C0146224", "name": "C0146224#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3641725", "name": "C3641725#ent", "pos": [13, 14]}}
{"token": ["Neurofilaments", ",", "part", "of", "the", "C1333200#ent", "<e1>", "network", ",", "and", "neuron", "specific", "enolase", ",", "a", "major", "C0014442#ent", "<e2>", "in", "glycolysis", ",", "are", "both", "present", "in", "central", "and", "peripheral", "neurons", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["The", "concentrations", "of", "extracellularly", "released", "nucleotides", "are", "controlled", "by", "metabolism", "via", "C1740167#ent", "<e1>", ",", "but", "the", "precise", "physiological", "roles", "of", "the", "C1099165#ent", "<e2>", "the", "modulation", "of", "purinergic", "receptor", "are", "still", "unclear", "."], "h": {"id": "C1740167", "name": "C1740167#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1099165", "name": "C1099165#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "indomethacin", ",", "a", "C0085387#ent", "<e1>", "was", "anti-inflammatory", "and", "reduced", "the", "formation", "of", "C0796254#ent", "<e2>", "in", "AIA", "rat", "paws", "."], "h": {"id": "C0085387", "name": "C0085387#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0796254", "name": "C0796254#ent", "pos": [15, 16]}}
{"token": ["RBP4", "levels", "were", "similar", "in", "C0456065#ent", "<e1>", "and", "term", "C0162311#ent", "<e2>", "women", ",", "while", "composite", "ISI", "was", "significantly", "lower", "in", "the", "former", "group"], "h": {"id": "C0456065", "name": "C0456065#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162311", "name": "C0162311#ent", "pos": [9, 10]}}
{"token": ["Furthermore", ",", "C1704947#ent", "<e1>", "induced", "with", "proteose", "peptone", "(", "PP", ")", "containing", "C1427674#ent", "<e2>", "could", "generate", "greater", "NO", "production", "than", "C1704947#ent", "<e1>", "induced", "with", "PP", "alone", "."], "h": {"id": "C1427674", "name": "C1427674#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [2, 3]}}
{"token": ["Hereditary", "hyperekplexia", "or", "familial", "startle", "disease", "C1835614#ent", "<e1>", ")", ",", "is", "an", "autosomal", "dominant", "neurologic", "disorder", "by", "marked", "C0026837#ent", "<e2>", "central", "nervous", "system", "and", "an", "exaggerated", "startle", "response", "unexpected", "acoustic", "or", "tactile", "stimuli", "."], "h": {"id": "C1835614", "name": "C1835614#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [18, 19]}}
{"token": ["NF-L", "should", "be", "investigated", "in", "CMT2", "as", "well", "as", "in", "C0270911#ent", "<e1>", "not", "associated", "with", "usual", "genes", "PMP22", ",", "Cx32", ",", "and", "C1419691#ent", "<e2>", "."], "h": {"id": "C0270911", "name": "C0270911#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1419691", "name": "C1419691#ent", "pos": [22, 23]}}
{"token": ["2", ")", "During", "neuroglucopenia", "or", "C0020616#ent", "<e1>", ",", "plasma", "PP", "is", "increased", "via", "nicotinic", "and", "C0026815#ent", "<e2>", "mechanisms", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026815", "name": "C0026815#ent", "pos": [15, 16]}}
{"token": ["Analysis", "of", "C1305923#ent", "<e1>", "mutations", "in", "the", "C3541334#ent", "<e2>", "and", "RT", "(", "reverse", "transcriptase", "domains", "indicated", "that", "both", "domains", "were", "required", "for", "in", "vitro", "nucleotide", "priming", "activity"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541334", "name": "C3541334#ent", "pos": [7, 8]}}
{"token": ["Following", "single", "dosage", "of", "pentazocine", "subjects", "more", "often", "reported", "a", "general", "feeling", "of", "discomfort", ",", "including", "nausea", ",", "dizziness", "and", "C0026603#ent", "<e1>", "than", "was", "the", "case", "after", "administration", "of", "C0060583#ent", "<e2>", "."], "h": {"id": "C0026603", "name": "C0026603#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0060583", "name": "C0060583#ent", "pos": [29, 30]}}
{"token": ["The", "results", "suggest", "that", "MMP-9", "is", "differentially", "regulated", "at", "mRNA", "and", "C0027203#ent", "<e1>", "by", "BPs", ",", "which", "affect", "ATP-dependent", "intracellular", "enzymes", "(", "C0008994#ent", "<e2>", ")", "or", "post-translational", "modification", "GTPases", "(", "pamidronate", ")", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0008994", "name": "C0008994#ent", "pos": [22, 23]}}
{"token": ["The", "duration", "of", "afterdischarges", "induced", "by", "electrical", "stimulation", "the", "dorsal", "hippocampus", "slightly", "inhibited", "by", "C0164488#ent", "<e1>", "and", "markedly", "inhibited", "by", "C0012010#ent", "<e2>", ",", "while", "buspirone", "enhanced", "the", "duration", "."], "h": {"id": "C0164488", "name": "C0164488#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0012010", "name": "C0012010#ent", "pos": [20, 21]}}
{"token": ["these", "results", ",", "taken", "together", "with", "previously", "published", "data", "suggest", "that", "oral", "administration", "C0067413#ent", "<e1>", "could", "be", "a", "useful", "strategy", "for", "stimulating", "endogenous", "insulin", "secretion", "C0011854#ent", "<e2>", "patients", "."], "h": {"id": "C0067413", "name": "C0067413#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [25, 26]}}
{"token": ["These", "distinct", "localization", "patterns", "of", "C1835417#ent", "<e1>", "and", "Bcr-Abl-AD", "enabled", "us", "to", "examine", "the", "localization", "of", "C1835417#ent", "<e1>", "substrate", "and", "C3539609#ent", "<e1>", "relation", "to", "C1835417#ent", "<e1>", "."], "h": {"id": "C3539609", "name": "C3539609#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1835417", "name": "C1835417#ent", "pos": [5, 6]}}
{"token": ["The", "fact", "that", "intracellular", "sterol", "sensors", "C3889135#ent", "<e1>", ",", "LXR", "and", "C3538602#ent", "<e2>", ")", "are", "involved", "in", "the", "control", "of", "I-BABP", "gene", "expression", "strongly", "suggest", "a", "crucial", "role", "for", "I-BABP", "in", "the", "ileum", "."], "h": {"id": "C3889135", "name": "C3889135#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3538602", "name": "C3538602#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "our", "results", "suggest", "that", "modulation", "of", "specific", "IgG4", "response", "and", "specific", "C1415975#ent", "<e1>", "response", "might", "be", "involved", "in", "the", "early", "and", "C0016204#ent", "<e2>", "during", "immunotherapy", ",", "respectively", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0016204", "name": "C0016204#ent", "pos": [24, 25]}}
{"token": ["This", "region", "contains", "the", "C0016719#ent", "<e1>", "raising", "the", "possibility", "that", "C0238190#ent", "<e2>", "may", "be", "a", "related", "neurogenic", "disorder"], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0238190", "name": "C0238190#ent", "pos": [10, 11]}}
{"token": ["The", "antihypertensive", "effect", "to", "be", "restricted", "to", "compounds", "with", "oxidation", "rates", "within", "a", "narrow", "range", ",", "indicating", "the", "unlikelihood", "of", "increasing", "the", "C0720099#ent", "<e1>", "of", "the", "pharmacologic", "effect", "stabilisation", "of", "the", "C0012315#ent", "<e2>"], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0012315", "name": "C0012315#ent", "pos": [31, 32]}}
{"token": ["Placebo-treated", "patients", "who", "were", "unable", "to", "complete", "the", "full", "8", "weeks", "because", "of", "uncontrolled", "C0042109#ent", "<e1>", "symptoms", "were", "entered", "into", "a", "2-month", "open", "C0085170#ent", "<e2>"], "h": {"id": "C0042109", "name": "C0042109#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0085170", "name": "C0085170#ent", "pos": [23, 24]}}
{"token": ["During", "sequence", "analysis", "the", "first", "intron", "of", "the", "human", "c-fms", "oncogene", "we", "identified", "an", "C1412821#ent", "<e1>", "encoding", "the", "C1419686#ent", "<e2>", "RPL7", ")", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419686", "name": "C1419686#ent", "pos": [18, 19]}}
{"token": ["The", "effects", "of", "dietary", "manipulations", "excretion", "of", "the", "porphyrin", "precursors", ",", "C0876231#ent", "<e1>", "ALA", ")", ",", "and", "C0032706#ent", "<e2>", "(", "PBG", ")", "were", "studied", "in", "eight", "patients", "with", "acute", "intermittent", "porphyria"], "h": {"id": "C0876231", "name": "C0876231#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0032706", "name": "C0032706#ent", "pos": [17, 18]}}
{"token": ["The", "Carvedilol", "or", "Metoprolol", "European", "Trial", "(", "COMET", ")", "demonstrated", "improved", "survival", "with", "carvedilol", "vs.", "C0700548#ent", "<e1>", "patients", "with", "C0018801#ent", "<e2>"], "h": {"id": "C0700548", "name": "C0700548#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [19, 20]}}
{"token": ["Increased", "NF-kappaB", "activity", "cytoplasmic", "accumulation", "of", "C0249197#ent", "<e1>", ")", "might", "counteract", "death-promoting", "effects", "elicited", "by", "overexpressed", "C1430988#ent", "<e2>", "and", "reduced", "activation", "of", "Akt", "and", "STAT3", "previously", "noted", "in", "these", "tissues", "."], "h": {"id": "C0249197", "name": "C0249197#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [16, 17]}}
{"token": ["Prokinetic", "agents", "as", "C0025853#ent", "<e1>", ",", "cisapride", "or", "erythromycin", "and", "substances", "like", "C0023992#ent", "<e2>", ",", "octreotide", "or", "clonidine", "are", "used", "to", "improve", "gastrointestinal", "dysfunction"], "h": {"id": "C0025853", "name": "C0025853#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023992", "name": "C0023992#ent", "pos": [12, 13]}}
{"token": ["Other", "nontraumatic", "disorders", "in", "both", "children", "and", "adults", ";", "these", "include", "anterior", "subluxation", "the", "sternoclavicular", "joint", "C0016719#ent", "<e1>", "hypertrophic", "osteitis", "chronic", "multifocal", "periosteitis", "and", "arthropathy", ",", "and", "C0029443#ent", "<e2>", "."], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0029443", "name": "C0029443#ent", "pos": [27, 28]}}
{"token": ["Furthermore", ",", "calcitonin", "decreased", "C1413085#ent", "<e1>", "mRNA", "expression", "in", "wildtype", "osteoclasts", ",", "but", "not", "in", "C1413706#ent", "<e2>", "knockout", "osteoclasts", "."], "h": {"id": "C1413085", "name": "C1413085#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413706", "name": "C1413706#ent", "pos": [15, 16]}}
{"token": ["Our", "models", "were", "well", "able", "to", "tackle", "the", "difficult", "problem", "of", "correctly", "predicting", "the", "MHC", "class", "C3539609#ent", "<e1>", "activities", "of", "a", "majority", "of", "the", "test", "set", "C0030956#ent", "<e2>", "."], "h": {"id": "C3539609", "name": "C3539609#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [26, 27]}}
{"token": ["C0040373#ent", "<e1>", "was", "ineffective", "as", "a", "blocking", "agent", "the", "effects", "of", "C0057577#ent", "<e2>", "."], "h": {"id": "C0040373", "name": "C0040373#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0057577", "name": "C0057577#ent", "pos": [11, 12]}}
{"token": ["Thus", "17beta-estradiol", "seemed", "to", "exert", "a", "dual", "effect", "activating", "the", "PI3K-Akt", "pathway", "by", "inhibiting", "C1430988#ent", "<e1>", "mRNA", "expression", "and", "also", "inhibiting", "nrf1", "and", "C1420696#ent", "<e2>", "mRNA", "expression", "."], "h": {"id": "C1430988", "name": "C1430988#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420696", "name": "C1420696#ent", "pos": [23, 24]}}
{"token": ["priB", "encodes", "a", "104-amino", "acid", "11.4-kDa", "polypeptide", "and", "corresponds", "to", "an", "previously", "identified", "open", "reading", "frame", "C1415932#ent", "<e1>", "and", "rps", "R", "within", "a", "C1539696#ent", "<e2>", "95.5", "min", "on", "the", "E.", "coli", "chromosome"], "h": {"id": "C1415932", "name": "C1415932#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [23, 24]}}
{"token": ["One", "sequence", "(", "C0067533#ent", "<e1>", ")", "maps", "in", "the", "L", "component", "whereas", "two", "sequences", "(", "C2369738#ent", "<e2>", ")", "map", "in", "the", "S", "component"], "h": {"id": "C0067533", "name": "C0067533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2369738", "name": "C2369738#ent", "pos": [15, 16]}}
{"token": ["The", "C0010709#ent", "<e1>", "was", "tentatively", "diagnosed", "as", "an", "C0078981#ent", "<e2>"], "h": {"id": "C0010709", "name": "C0010709#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0078981", "name": "C0078981#ent", "pos": [8, 9]}}
{"token": ["Only", "one", "C0010709#ent", "<e1>", "failed", "to", "detect", "during", "metrizamide", "myelography", "but", "a", "metrizamide", "CT", "the", "C0078981#ent", "<e2>", "in", "this", "case", "."], "h": {"id": "C0010709", "name": "C0010709#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0078981", "name": "C0078981#ent", "pos": [15, 16]}}
{"token": ["These", "findings", "raise", "the", "possibility", "that", "certain", "pathologic", "conditions", "be", "treated", "by", "C2712370#ent", "<e1>", "the", "cell", "death-inducing", "capability", "of", "C1539478#ent", "<e2>", "with", "drugs", "affecting", "its", "raft", "localization", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [19, 20]}}
{"token": ["The", "centrally", "mediated", "increase", "in", "sympathetic", "outflow", "caused", "by", "C2825234#ent", "<e1>", "attended", "by", "induction", "of", "heart", "C1704862#ent", "<e2>", "activity", "and", "depletion", "of", "adrenal", "epinephrine", "EPI", ")", "."], "h": {"id": "C2825234", "name": "C2825234#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704862", "name": "C1704862#ent", "pos": [16, 17]}}
{"token": ["Diarrhoea", ",", "C0004775#ent", "<e1>", "conjunctivitis", "and", "C0038358#ent", "<e2>", "occurred", "on", "the", "farms", "where", "the", "diagnoses", "were", "made", "."], "h": {"id": "C0004775", "name": "C0004775#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [6, 7]}}
{"token": ["To", "study", "the", "interaction", "between", "the", "human", "C1333188#ent", "<e1>", "cystatin", "C", "and", "proteinases", "of", "C0031099#ent", "<e2>", "associated", "bacteria", "."], "h": {"id": "C1333188", "name": "C1333188#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031099", "name": "C0031099#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "behavioral", "sensitization", "to", "an", "intra-accumbens", "challenge", "with", "the", "C0022614#ent", "<e1>", "receptor-specific", "agonist", ",", "1-aminocyclobutane-cis-1,3-dicarboxylic", "acid", "(", "C0526665#ent", "<e2>", ")", ",", "was", "seen", "in", "both", "cocaine-treated", "subject", "groups"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0526665", "name": "C0526665#ent", "pos": [19, 20]}}
{"token": ["C1705969#ent", "<e1>", "exposure", "had", "no", "effect", "C0081434#ent", "<e2>", "in", "liver", "cytosol", "male", "rats", "."], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0081434", "name": "C0081434#ent", "pos": [6, 7]}}
{"token": ["Pain", "or", "C0231218#ent", "<e1>", ",", "pruritus", "and", "faecal", "soiling", "much", "commoner", "in", "the", "pretreatment", "C0019112#ent", "<e2>", "compared", "to", "controls", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019112", "name": "C0019112#ent", "pos": [14, 15]}}
{"token": ["In", "type", "1", "diabetes", "pancreatic", "beta", "cells", "destroyed", "by", "autoimmune", "phenomena", "a", "linear", "sequence", "homology", "between", "a", "major", "C1413096#ent", "<e1>", ",", "glutamate", "decarboxylase", "GAD", ")", ",", "and", "the", "C0247248#ent", "<e2>", "coxsackie", "B4", "identified", "."], "h": {"id": "C1413096", "name": "C1413096#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0247248", "name": "C0247248#ent", "pos": [28, 29]}}
{"token": ["Thus", ",", "the", "methylation", "status", "of", "C0596240#ent", "<e1>", "distinct", "in", "different", "STS", "and", "methylation", "of", "C1419285#ent", "<e2>", "promoter", "can", "serve", "as", "prognostic", "marker", "STSs", "."], "h": {"id": "C0596240", "name": "C0596240#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419285", "name": "C1419285#ent", "pos": [15, 16]}}
{"token": ["The", "tumor", "suppressor", "C0596240#ent", "<e1>", "except", "APC", "and", "C1419285#ent", "<e2>", ",", "were", "generally", "unmethylated", "in", "samples", "obtained", "from", "people", "who", "were", "less", "than", "32", "years", "old", "(", "n=11", ")", "."], "h": {"id": "C0596240", "name": "C0596240#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419285", "name": "C1419285#ent", "pos": [8, 9]}}
{"token": ["Many", "PC", "substrates", "are", "well", "known", "C0965053#ent", "<e1>", "as", "growth", "factors", "growth", "factor", "receptors", "integrins", ",", "and", "matrix", "metalloproteases", "C0623362#ent", "<e2>", ")", "."], "h": {"id": "C0965053", "name": "C0965053#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [19, 20]}}
{"token": ["Consecutive", "C0044602#ent", "<e1>", "and", "PIKK-independent", "steps", "in", "activation", "of", "C1706047#ent", "<e2>", "are", "key", "steps", "for", "controlling", "and", "transmitting", "diverse", "downstream", "responses", "to", "DNA", "damage"], "h": {"id": "C0044602", "name": "C0044602#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706047", "name": "C1706047#ent", "pos": [9, 10]}}
{"token": ["A", "total", "of", "9,759", "patients", "with", "chronic", "obstructive", "pulmonary", "disease", "COPD", ")", ",", "sequelae", "of", "C0041296#ent", "<e1>", "(", "TBsq", ")", ",", "and", "chronic", "interstitial", "pneumonia", "C3273618#ent", "<e2>", ")", "were", "selected", "in", "1,212", "medical", "institutions", "analysis", "of", "survival", "rates"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3273618", "name": "C3273618#ent", "pos": [25, 26]}}
{"token": ["These", "results", "suggest", "that", "BmNPV", "C1705001#ent", "<e1>", "oligomerization", "and", "C1336849#ent", "<e2>", "functional", "domains", "nuclear", "foci", "formation", "."], "h": {"id": "C1705001", "name": "C1705001#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1336849", "name": "C1336849#ent", "pos": [9, 10]}}
{"token": ["Consistent", "with", "its", "interaction", "with", "LNA", ",", "nuclear", "localization", "and", "possession", "of", "two", "leucine", "zipper", "motifs", "C1427498#ent", "<e1>", "behaved", "like", "a", "transcriptional", "factor", "repressed", "C1333929#ent", "<e2>", "TK", ")", "promoter", "activity", "a", "mammalian", "one-hybrid", "assay", "."], "h": {"id": "C1427498", "name": "C1427498#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1333929", "name": "C1333929#ent", "pos": [24, 25]}}
{"token": ["We", "have", "identified", "Kr\u00fcppel-like", "factor-6", "KLF6", ")", ",", "a", "recently", "described", "C0079427#ent", "<e1>", "as", "a", "repressor", "of", "the", "proto-oncogene", "Delta-like", "1", "C3274855#ent", "<e2>", ")", ",", "a", "gene", "encoding", "a", "transmembrane", "protein", "inhibits", "adipocyte", "differentiation", "."], "h": {"id": "C0079427", "name": "C0079427#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3274855", "name": "C3274855#ent", "pos": [21, 22]}}
{"token": ["These", "unusual", "electroretinographic", "findings", "are", "pathognomonic", "of", "Alstr\u00f6m", "'s", "syndrome", "and", "different", "from", "other", "C0035334#ent", "<e1>", "other", "syndromes", "with", "similar", "phenotypes", "such", "as", "Bardet-Biedl", ",", "C0023138#ent", "<e2>", ",", "and", "Cohen", "syndromes"], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0023138", "name": "C0023138#ent", "pos": [25, 26]}}
{"token": ["Cardiac", "expression", "Irx1", ",", "Irx2", ",", "and", "C1422593#ent", "<e1>", "may", "partially", "compensate", "for", "loss", "of", "C1416477#ent", "<e2>", "function", "."], "h": {"id": "C1422593", "name": "C1422593#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416477", "name": "C1416477#ent", "pos": [15, 16]}}
{"token": ["C1415652#ent", "<e1>", "and", "COX-2", "mRNA", "expression", "in", "C2826547#ent", "<e2>", "chlamydial", "infection", "quantified", "with", "real-time", "polymerase", "chain", "reaction"], "h": {"id": "C1415652", "name": "C1415652#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2826547", "name": "C2826547#ent", "pos": [7, 8]}}
{"token": ["Eight", "C0079941#ent", "<e1>", "correspond", "to", "the", "C3541884#ent", "<e2>", ",", "SMP3", ",", "PDR5", ",", "NFI1", ",", "PUP1", ",", "PET123", "and", "MTR10", "loci", ",", "described", "previously", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3541884", "name": "C3541884#ent", "pos": [6, 7]}}
{"token": ["The", "second", "mitogenic", "signal", ",", "which", "can", "be", "provided", "by", "the", "C0879590#ent", "<e1>", "leads", "to", "inactivation", "of", "this", "inhibitor", ",", "thereby", "allowing", "C0108855#ent", "<e2>", "activation", "and", "progression", "into", "S", "phase"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0108855", "name": "C0108855#ent", "pos": [22, 23]}}
{"token": ["Groups", "of", "patients", "with", "C0079173#ent", "<e1>", "arthrogenic", "or", "C1417575#ent", "<e2>", "also", "tested", "."], "h": {"id": "C0079173", "name": "C0079173#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417575", "name": "C1417575#ent", "pos": [8, 9]}}
{"token": ["We", "have", "reported", "three", "cases", "of", "hyperornithinaemia", "associated", "with", "C0220994#ent", "<e1>", "and", "homocitrullinuria", "(", "C0268540#ent", "<e2>", ")", "."], "h": {"id": "C0220994", "name": "C0220994#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0268540", "name": "C0268540#ent", "pos": [14, 15]}}
{"token": ["In", "contrast", ",", "Ig", "eluted", "from", "RBC", "obtained", "from", "C0024141#ent", "<e1>", "patients", "with", "DAT", "positive", "C0002878#ent", "<e2>", "to", "be", "polyclonal", "autoantibodies", "both", "light", "chain", "types", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [15, 16]}}
{"token": ["Considering", "that", "C0265220#ent", "<e1>", "is", "a", "recently", "described", "C0039082#ent", "<e2>", "and", "is", "also", "very", "rare", ",", "therapeutic", "approaches", "still", "not", "consensual", "."], "h": {"id": "C0265220", "name": "C0265220#ent", "pos": [2, 3]}, "relation": "has_nichd_parent", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [8, 9]}}
{"token": ["This", "result", "suggested", "that", "G2", "delay", "not", "expressed", "until", "the", "cells", "that", "were", "in", "S-phase", "at", "the", "time", "of", "treatment", "with", "C0594375#ent", "<e1>", "proceeded", "into", "C1824309#ent", "<e2>", "."], "h": {"id": "C0594375", "name": "C0594375#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1824309", "name": "C1824309#ent", "pos": [25, 26]}}
{"token": ["the", "drug", "was", "found", "to", "possess", "potent", "antigastric", "secretory", "C0003216#ent", "<e1>", "both", "in", "shay", "and", "C0400807#ent", "<e2>", "and", "did", "not", "exhibit", "any", "peripheral", "parasympathetic", "blocking", "activity"], "h": {"id": "C0003216", "name": "C0003216#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0400807", "name": "C0400807#ent", "pos": [15, 16]}}
{"token": ["These", "results", "provide", "evidence", "that", "C0072115#ent", "<e1>", "is", "C0085536#ent", "<e2>", "suggest", "that", "the", "activity", "of", "C0072115#ent", "<e1>", "may", "be", "up", "regulated", "by", "the", "enzyme", "phosphorylation", "."], "h": {"id": "C0085536", "name": "C0085536#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0072115", "name": "C0072115#ent", "pos": [5, 6]}}
{"token": ["3", ")", "Cephaeline", "and", "emetine", "did", "not", "affect", "activities", "of", "metabolic", "C3541394#ent", "<e1>", "of", "5-HT", "and", "dopamine", "(", "MAO-A", ",", "MAO-B", ",", "C1566598#ent", "<e2>", "tyrosine", "hydroxylase", "in", "vitro"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1566598", "name": "C1566598#ent", "pos": [22, 23]}}
{"token": ["Immunostaining", "against", "the", "nuclear", "antigen", "C0087140#ent", "<e1>", "and", "the", "C0041491#ent", "<e2>", "TH", ")", "showed", "that", "40", "%", "of", "all", "c-Fos-LI-positive", "cells", "in", "the", "LC/SC", "were", "TH-LI", "positive", "at", "25", "micrograms", "CCK/kg", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0041491", "name": "C0041491#ent", "pos": [9, 10]}}
{"token": ["Consequently", ",", "our", "results", "suggest", "that", "C0087140#ent", "<e1>", "exerts", "its", "influence", "on", "the", "C0041491#ent", "<e2>", "multiple", "mechanisms", "that", "are", "dependent", "and", "independent", "of", "the", "proximal", "promoter", "AP1", "site", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0041491", "name": "C0041491#ent", "pos": [13, 14]}}
{"token": ["We", "have", "identified", "a", "new", "basic", "helix-loop-helix", "(", "BHLH", ")", "C0812382#ent", "<e1>", "designated", "TFEC", ",", "which", "is", "closely", "related", "to", "C1336608#ent", "<e2>", "and", "TFEB", "."], "h": {"id": "C0812382", "name": "C0812382#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1336608", "name": "C1336608#ent", "pos": [20, 21]}}
{"token": ["For", "example", ",", "C1417500#ent", "<e1>", "+", "is", "a", "cofactor", "for", "the", "C1417857#ent", "<e2>", "NSF", ")", "ATPase", ",", "and", "the", "Ca2", "+", "signal", "from", "neuronal", "membrane", "depolarization", "required", "for", "synaptotagmin", "activation"], "h": {"id": "C1417500", "name": "C1417500#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417857", "name": "C1417857#ent", "pos": [11, 12]}}
{"token": ["Platelet", "activating", "factor", "C0235480#ent", "<e1>", ")", ",", "a", "phospholipid", "associated", "with", "C0029877#ent", "<e2>", "has", "been", "shown", "to", "both", "prime", "and", "amplify", "the", "release", "of", "superoxide", "anion", "hydrogen", "peroxide", "polymorphonuclear", "neutrophils", "macrophages", "stimulated", "by", "FMLP", "or", "PMA", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [11, 12]}}
{"token": ["Mitochondrial", "disorder", "mimic", "motor", "neuron", "disease", "muscle", "biopsy", "mimic", "C0027121#ent", "<e1>", ",", "and", "may", "show", "only", "little", "evidence", "for", "C0035204#ent", "<e2>"], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [19, 20]}}
{"token": ["Neuroleptic", "malignant", "syndrome", "C1744687#ent", "<e1>", ")", "is", "an", "C0272178#ent", "<e2>", "and", "uncommon", "but", "serious", "adverse", "effect", "has", "been", "reported", "with", "both", "typical", "and", "atypical", "antipsychotic", "agents"], "h": {"id": "C1744687", "name": "C1744687#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0272178", "name": "C0272178#ent", "pos": [8, 9]}}
{"token": ["To", "evaluate", "the", "efficacy", "of", "4-aminopyridine", "sustained", "release", "(", "4AP", "SR", ")", "(", "C0000477#ent", "<e1>", ",", "EL-970", ")", "using", "quantitative", "measures", "of", "motor", "function", "multiple", "sclerosis", "C0026769#ent", "<e2>", ")", "patients", "."], "h": {"id": "C0000477", "name": "C0000477#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [26, 27]}}
{"token": ["Systemic", "manifestations", "arthritis", "or", "C0003862#ent", "<e1>", ",", "Raynaud's", "phenomenon", ",", "serositis", ",", "vascular", "headaches", "C0022658#ent", "<e2>", "myositis", ",", "and", "sicca", "syndrome"], "h": {"id": "C0003862", "name": "C0003862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [14, 15]}}
{"token": ["In", "T24", "cells", ",", "the", "maximum", "effect", "was", "achieved", "by", "1,000", "U/ml", "of", "C1415900#ent", "<e1>", ",", "which", "increased", "the", "expression", "of", "C1565860#ent", "<e2>", "up", "to", "2.4-fold", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1565860", "name": "C1565860#ent", "pos": [21, 22]}}
{"token": ["The", "antigonadal", "effects", "of", "C0083220#ent", "<e1>", "GnRH-A", ")", "are", "mediated", "both", "through", "C0032002#ent", "<e2>", "and", "testicular", "inhibitory", "mechanisms", "in", "the", "rat", "."], "h": {"id": "C0083220", "name": "C0083220#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [12, 13]}}
{"token": ["This", "review", "will", "focus", "on", "the", "role", "of", "ERCP", "in", "specific", "causes", "of", "acute", "pancreatitis", "including", "microlithiasis", "and", "C0008350#ent", "<e1>", "pancreas", "divisum", "Sphincter", "of", "Oddi", "dysfunction", "tumors", "of", "the", "C4054251#ent", "<e2>", "pancreatic", "pseudocysts", "and", "pancreatic", "duct", "injury"], "h": {"id": "C0008350", "name": "C0008350#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C4054251", "name": "C4054251#ent", "pos": [29, 30]}}
{"token": ["Based", "on", "an", "analysis", "of", "published", "data", "the", "C1335278#ent", "<e1>", "effect", "of", "formates", ",", "C0060276#ent", "<e2>", "and", "citrates", "did", "not", "differ", "in", "weaned", "piglets", "."], "h": {"id": "C1335278", "name": "C1335278#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0060276", "name": "C0060276#ent", "pos": [14, 15]}}
{"token": ["Binding", "of", "2", "mol", "trypsin", "as", "1", "mol", "elastase", "I", "C0069695#ent", "<e1>", "does", "not", "interfere", "with", "the", "binding", "of", "C0030306#ent", "<e2>"], "h": {"id": "C0069695", "name": "C0069695#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [19, 20]}}
{"token": ["Photochemotherapy", "with", "C0740123#ent", "<e1>", "und", "UV-A", "is", "a", "modality", "to", "treat", "C0263361#ent", "<e2>", "."], "h": {"id": "C0740123", "name": "C0740123#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0263361", "name": "C0263361#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "investigate", "the", "existence", "of", "allelic", "imbalance", "at", "C3828460#ent", "<e1>", ",", "CAPN5", ",", "and", "PAK1", ",", "as", "candidate", "C1417679#ent", "<e2>", "within", "11q13.5-q14", "region", "using", "a", "single", "nucleotide", "polymorphism-based", "analysis"], "h": {"id": "C3828460", "name": "C3828460#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [24, 25]}}
{"token": ["Furthermore", ",", "MRI", "can", "accurately", "depict", "cases", "of", "labyrinthitis", "or", "of", "C0029134#ent", "<e1>", "of", "the", "facial", "nerve", "of", "C0007820#ent", "<e2>", "by", "middle", "ear", "processes", "while", "this", "is", "not", "always", "possible", "by", "HRCT", "."], "h": {"id": "C0029134", "name": "C0029134#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [18, 19]}}
{"token": ["The", "treatment", "of", "cholestasis", "should", "include", "a", "management", "of", "complications", "such", "as", "pruritus", ",", "C0029453#ent", "<e1>", "and", "correction", "of", "fat", "soluble", "C0376286#ent", "<e2>"], "h": {"id": "C0029453", "name": "C0029453#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0376286", "name": "C0376286#ent", "pos": [21, 22]}}
{"token": ["As", "a", "consequence", ",", "expression", "of", "the", "C0216876#ent", "<e1>", "targets", ",", "ANF", "and", "C1423951#ent", "<e2>", ",", "is", "drastically", "downregulated", "."], "h": {"id": "C0216876", "name": "C0216876#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423951", "name": "C1423951#ent", "pos": [13, 14]}}
{"token": ["The", "5HT", "antagonists", "cyproheptadine", "and", "C0025912#ent", "<e1>", "blocked", "the", "contractile", "effects", "all", "of", "the", "C2987634#ent", "<e2>", "."], "h": {"id": "C0025912", "name": "C0025912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [14, 15]}}
{"token": ["Without", "exception", "C1706331#ent", "<e1>", ",", "NPC", ",", "ND", "and", "PAG", "C0042345#ent", "<e2>", "are", "presynaptic", "to", "dendritic", "profiles", "in", "the", "EW", "nucleus", "contain", "electron", "dense", "mitochondria", ",", "round", "vesicles", "make", "asymmetric", "synaptic", "contacts", "."], "h": {"id": "C1706331", "name": "C1706331#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [10, 11]}}
{"token": ["A", "2-year-old", "boy", "with", "macrocephaly", ",", "C0009451#ent", "<e1>", "and", "mild", "hepatosplenomegaly", "found", "to", "have", "mild", "Hunter", "syndrome", "C0086647#ent", "<e2>", "."], "h": {"id": "C0009451", "name": "C0009451#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0086647", "name": "C0086647#ent", "pos": [17, 18]}}
{"token": ["C1418660#ent", "<e1>", "is", "a", "member", "of", "an", "emerging", "family", "of", "proteins", "the", "C3890221#ent", "<e2>", "family", ",", "implicated", "in", "the", "control", "of", "cell", "growth", "differentiation", "."], "h": {"id": "C1418660", "name": "C1418660#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890221", "name": "C3890221#ent", "pos": [12, 13]}}
{"token": ["In", "the", "model", ",", "we", "examined", "the", "effects", "of", "pituitary", "adenylate", "cyclase-activating", "polypeptide", "C0017789#ent", "<e1>", "alone", "and", "in", "combination", "on", "C1418464#ent", "<e2>", "and", "per2", "gene", "expression", "late", "subjective", "night", "circadian", "time", "19", ")", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418464", "name": "C1418464#ent", "pos": [20, 21]}}
{"token": ["The", "mechanism", "of", "C0171023#ent", "<e1>", "oxidation", "with", "C0075432#ent", "<e2>", "was", "also", "proposed", "."], "h": {"id": "C0171023", "name": "C0171023#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0075432", "name": "C0075432#ent", "pos": [7, 8]}}
{"token": ["This", "increase", "in", "C0086661#ent", "<e1>", "mRNA", "was", "abolished", "by", "C0298346#ent", "<e2>", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0298346", "name": "C0298346#ent", "pos": [9, 10]}}
{"token": ["That", "is", "especially", "a", "C1848862#ent", "<e1>", "of", "a", "low", "trijodthyronin", "level", "marked", "as", "euthyroid", "C0037050#ent", "<e2>", "is", "significantly", "more", "frequent", "in", "patients", "with", "chronic", "heart", "failure", "to", "a", "population", "of", "healthy", "individuals", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037050", "name": "C0037050#ent", "pos": [14, 15]}}
{"token": ["SOD", ",", "CAT", ",", "RBCs", ",", "and", "C0059804#ent", "<e1>", "are", "antioxidants", ",", "whereas", "RR", "is", "a", "C0001645#ent", "<e2>", "of", "transmembrane", "Ca2", "fluxes", "."], "h": {"id": "C0059804", "name": "C0059804#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [16, 17]}}
{"token": ["Antigenic", "determinants", "the", "C0086376#ent", "<e1>", "recognized", "by", "the", "mAb", "were", "resistant", "to", "sodium", "periodate", "C0001057#ent", "<e2>", "treatment", ",", "suggesting", "reactivity", "with", "peptide", "and", "not", "carbohydrate", "structures"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001057", "name": "C0001057#ent", "pos": [14, 15]}}
{"token": ["BACKGROUND", ":", "Polymorphisms", "in", "several", "genes", "(", "NOD2", ",", "C1704939#ent", "<e1>", ",", "SLC22A4", ")", "have", "been", "associated", "with", "susceptibility", "to", "C0010346#ent", "<e2>"], "h": {"id": "C1704939", "name": "C1704939#ent", "pos": [9, 10]}, "relation": "gene_associated_with_disease", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [20, 21]}}
{"token": ["Cardiohemodynamic", "effects", "and", "the", "C0001645#ent", "<e1>", "a", "new", "beta-adrenoceptor", "blocking", "agent", "bopindolol", "(", "C4255576#ent", "<e2>", ")", "were", "compared", "with", "those", "of", "pindolol", "in", "conscious", "unrestrained", "dogs", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C4255576", "name": "C4255576#ent", "pos": [13, 14]}}
{"token": ["The", "results", "suggest", "that", "M-CSF", "enhances", "net", "hydrolysis", "CE", "by", "stimulating", "the", "two", "CE", "C0020289#ent", "<e1>", "to", "a", "greater", "extent", "than", "C1258847#ent", "<e2>", ",", "and", "M-CSF", "may", "reduce", "the", "rate", "of", "atherogenesis", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [14, 15]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [21, 22]}}
{"token": ["C0020289#ent", "<e1>", "B", ",", "C", ",", "and", "C1258847#ent", "<e2>", "all", "have", "a", "C-terminal", "consensus", "sequence", "HXEL", ")", "for", "retaining", "proteins", "in", "the", "endoplasmic", "reticulum", "and", "these", "carboxylesterases", "are", "found", "in", "rat", "liver", "microsomes", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [0, 1]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1258847", "name": "C1258847#ent", "pos": [7, 8]}}
{"token": ["Mononeuritis", "was", "present", "in", "13", ",", "C0032541#ent", "<e1>", "62", ",", "and", "distal", "symmetrical", "sensory", "or", "C1112256#ent", "<e2>", "19", "patients", "."], "h": {"id": "C0032541", "name": "C0032541#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1112256", "name": "C1112256#ent", "pos": [15, 16]}}
{"token": ["Necropsy", "demonstrated", "C0040558#ent", "<e1>", "axonal", "degeneration", "nerve", "roots", "compatible", "with", "the", "axonal", "form", "of", "C0018378#ent", "<e2>", "."], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [14, 15]}}
{"token": ["The", "incidence", "figures", "for", "asthma", ",", "C2607914#ent", "<e1>", "dermatitis", ",", "as", "well", "as", "the", "occurrence", "of", "recurrent", "C0699744#ent", "<e2>", ",", "were", "three", "to", "four", "times", "higher", "than", "in", "the", "controls", "."], "h": {"id": "C2607914", "name": "C2607914#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0699744", "name": "C0699744#ent", "pos": [17, 18]}}
{"token": ["In", "vitro", "in", "vivo", "studies", "demonstrated", "the", "insulinotropic", "effect", "of", "C0906166#ent", "<e1>", "is", "more", "potent", "than", "that", "of", "C0903898#ent", "<e2>", ",", "and", "C0906166#ent", "<e1>", "surpassed", "in", "controlling", "postprandial", "hyperglycemia", "in", "normal", "and", "diabetic", "animals", "."], "h": {"id": "C0906166", "name": "C0906166#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0903898", "name": "C0903898#ent", "pos": [18, 19]}}
{"token": ["Andersen", "syndrome", "AS", ")", "is", "a", "rare", "C0019247#ent", "<e1>", "by", "mutations", "of", "the", "potassium", "channel", "Kir2.1", "C1416584#ent", "<e2>", ")", "."], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1416584", "name": "C1416584#ent", "pos": [16, 17]}}
{"token": ["MMP-1", ",", "MMP-9", ",", "and", "C0042071#ent", "<e1>", "ECs", "were", "strongly", "up-regulated", "by", "C1704952#ent", "<e2>", "in", "the", "presence", "of", "VEGF", "in", "vitro"], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704952", "name": "C1704952#ent", "pos": [12, 13]}}
{"token": ["The", "same", "homogenates", "also", "showed", "a", "significant", "decrease", "in", "C1839259#ent", "<e1>", "after", "treatment", "with", "0.5", "mM", "C0031428#ent", "<e2>", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [16, 17]}}
{"token": ["Unlike", "other", "characterized", "C1334539#ent", "<e1>", "this", "enzyme", "is", "not", "regulated", "by", "C1413098#ent", "<e2>", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413098", "name": "C1413098#ent", "pos": [11, 12]}}
{"token": ["In", "the", "present", "study", ",", "we", "show", "that", "the", "expression", "of", "type", "2", "glucose", "transporter", "isoform", "C1420172#ent", "<e1>", ")", "could", "be", "regulated", "by", "C1418779#ent", "<e2>", "in", "the", "liver", "."], "h": {"id": "C1420172", "name": "C1420172#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [23, 24]}}
{"token": ["C0521668#ent", "<e1>", "to", "reversible", "cerebral", "vasoconstriction", "THARCV", ")", "is", "a", "C0039082#ent", "<e2>", "observed", "in", "a", "number", "of", "reported", "cases", "."], "h": {"id": "C0521668", "name": "C0521668#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [10, 11]}}
{"token": ["Pretreatment", "with", "Org", "6582", "C0724555#ent", "<e1>", ",", "zimelidine", "or", "C0060145#ent", "<e2>", "at", "doses", "devoid", "of", "antinociceptive", "activity", "potentiated", "morphine-", "but", "not", "methadone-", "or", "pethidine-induced", "antinociception", "."], "h": {"id": "C0724555", "name": "C0724555#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060145", "name": "C0060145#ent", "pos": [9, 10]}}
{"token": ["Attention", "was", "focused", "on", "emphatic", "predisposition", "cancer", "localized", "on", "subhyoid", "part", "of", "C0014541#ent", "<e1>", "to", "penetrate", "into", "C1825832#ent", "<e2>", "space", "."], "h": {"id": "C0014541", "name": "C0014541#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1825832", "name": "C1825832#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "after", "unilateral", "administration", ",", "significant", "dilation", "of", "pupil", "in", "the", "control", "eyes", "observed", "with", "C0041190#ent", "<e1>", "and", "atropine", "but", "not", "with", "C0013227#ent", "<e2>", "suggesting", "the", "systemic", "activity", "C0013227#ent", "<e2>", "minimal", "."], "h": {"id": "C0041190", "name": "C0041190#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [24, 25]}}
{"token": ["Barrier", "function", "intestinal", "segments", "impaired", "only", "in", "the", "T/HS", "rats", "resuscitated", "with", "C1419337#ent", "<e1>", "and", "histological", "analysis", "fewer", "injured", "C1421450#ent", "<e2>", "in", "the", "T/HS", "rats", "resuscitated", "with", "HTS", "than", "C1419337#ent", "<e1>", "."], "h": {"id": "C1419337", "name": "C1419337#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1421450", "name": "C1421450#ent", "pos": [19, 20]}}
{"token": ["C0011880#ent", "<e1>", "DKA", ")", "may", "be", "defined", "as", "a", "C0025517#ent", "<e2>", "characterized", "by", "hyperglycemia", ",", "acidosis", "and", "ketonuria", "."], "h": {"id": "C0011880", "name": "C0011880#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [9, 10]}}
{"token": ["Also", "3", "patients", "with", "C0014057#ent", "<e1>", "3", "with", "fungal", "meningitis", "each", "one", "with", "C0025297#ent", "<e2>", "tuberculous", "meningitis", "brainstem", "encephalitis", "analyzed", "."], "h": {"id": "C0014057", "name": "C0014057#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [13, 14]}}
{"token": ["Our", "results", "suggest", "stable", "core", "complexes", "components", "comprised", "of", "C1335803#ent", "<e1>", ",", "SAFB2", "and", "the", "RNA", "binding", "proteins", "C3539665#ent", "<e2>", "and", "hnRNPG", "exist", "in", "parallel", "with", "free", "SAFB1", "protein"], "h": {"id": "C1335803", "name": "C1335803#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3539665", "name": "C3539665#ent", "pos": [18, 19]}}
{"token": ["Using", "patient", "related", "examples", ",", "the", "toxicity", "of", "C0003211#ent", "<e1>", "disease", "modifying", "antirheumatic", "drugs", "DMARD", ")", "in", "C3714757#ent", "<e2>", "JA", ")", "is", "discussed", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [17, 18]}}
{"token": ["FLRX", ",", "a", "quinoline", "derivative", "be", "a", "C3826984#ent", "<e1>", "as", "well", "as", "C0008806#ent", "<e2>", ",", "lomefloxacin", "and", "sparfloxacin", "."], "h": {"id": "C3826984", "name": "C3826984#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0008806", "name": "C0008806#ent", "pos": [12, 13]}}
{"token": ["To", "introduce", "a", "C4283853#ent", "<e1>", "starting", "molecule", "3-formylpinane", "was", "reduced", "to", "the", "C0001975#ent", "<e2>", "followed", "by", "a", "substitution", "of", "the", "hydroxy", "group", "a", "bromide", "."], "h": {"id": "C4283853", "name": "C4283853#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [12, 13]}}
{"token": ["Prolactin", "restored", "normal", "activity", "ATP", "citrate", "lyase", "malic", "enzyme", "C1367441#ent", "<e1>", "not", "of", "C0022157#ent", "<e2>", "malate", "dehydrogenase", "MDH", ")", "."], "h": {"id": "C1367441", "name": "C1367441#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022157", "name": "C0022157#ent", "pos": [13, 14]}}
{"token": ["Ten", "patients", "improved", "with", "C0350422#ent", "<e1>", "D", ")", "and", "C0134337#ent", "<e2>", "(", "O", ")", "."], "h": {"id": "C0350422", "name": "C0350422#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0134337", "name": "C0134337#ent", "pos": [9, 10]}}
{"token": ["Moreover", ",", "quantitative", "chromatin", "immunoprecipitation", "assays", "that", "RTEF-1", "bound", "to", "the", "C1825950#ent", "<e1>", "element-containing", "region", "within", "the", "SM", "alpha-actin", "promoter", "myofibroblasts", ",", "whereas", "C1420682#ent", "<e2>", "was", "bound", "to", "the", "same", "region", "in", "differentiated", "SMCs", "."], "h": {"id": "C1825950", "name": "C1825950#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420682", "name": "C1420682#ent", "pos": [23, 24]}}
{"token": ["Patient", "presented", "with", "C0034216#ent", "<e1>", "of", "the", "left", "kidney", "to", "a", "large", "C0333014#ent", "<e2>", "was", "treated", "with", "tube", "nephrostomy", "by", "nephrectomy", "."], "h": {"id": "C0034216", "name": "C0034216#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0333014", "name": "C0333014#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "C0004057#ent", "<e1>", ",", "oxybutynin", "and", "C0033216#ent", "<e2>", "were", "hydrolyzed", "by", "only", "carboxylesterase", "pI", "4.5", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "C1419141#ent", "<e1>", "clearly", "identified", "non-high", "risk", "group", "clinical", "VT", "or", "C0002895#ent", "<e2>", "which", "have", "no", "inducible", "sustained", "monomorphic", "VT", "with", "high", "negative", "predictive", "value", "."], "h": {"id": "C1419141", "name": "C1419141#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "a", "patient", "diagnosed", "with", "lethal", "C0268412#ent", "<e1>", "a", "unique", "clinical", "presentation", "C0036572#ent", "<e2>", "that", "responded", "to", "vitamin", "B6"], "h": {"id": "C0268412", "name": "C0268412#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [13, 14]}}
{"token": ["A", "thrombin", "(", "C4084825#ent", "<e1>", "inhibitor", "(", "americanin", ")", "was", "isolated", "from", "the", "C0036091#ent", "<e2>", "the", "lone", "star", "tick", "Amblyomma", "americanum", "L.", ")", "using", "reversed-phase", "chromatography", "anion-exchange", "chromatography"], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "ROS", "inhibitor", "C0007367#ent", "<e1>", "and", "the", "nonantioxidant", "LT", "synthesis", "blocker", "C0022716#ent", "<e2>", "886", "inhibited", "the", "PMN", "+", "FMLP", "increase", "in", "Kf", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022716", "name": "C0022716#ent", "pos": [13, 14]}}
{"token": ["PC-3", "cells", "expressed", "PKCalpha", ",", "epsilon", ",", "zeta", ",", "iota", ",", "and", "C1868682#ent", "<e1>", "(", "PKCmicro", ")", ",", "as", "did", "another", "human", "AI", "C1415793#ent", "<e2>", "cell", "line", "distinct", "genetic", "origin", "DU145", "."], "h": {"id": "C1868682", "name": "C1868682#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1415793", "name": "C1415793#ent", "pos": [23, 24]}}
{"token": ["The", "tremorolytic", "effects", "of", "C0033148#ent", "<e1>", "and", "phenobarbital", "in", "essential", "C0040822#ent", "<e2>", "hands", "and", "head", "were", "compared", "in", "a", "double-blind", ",", "placebo-controlled", "trial"], "h": {"id": "C0033148", "name": "C0033148#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0040822", "name": "C0040822#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "an", "C0234533#ent", "<e1>", "focus", "and", "C0085584#ent", "<e2>", "diagnosed", "."], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [7, 8]}}
{"token": ["A", "patient", "with", "C0234533#ent", "<e1>", "mental", "and", "psychotic", "signs", "was", "diagnosed", "as", "suffering", "from", "C0085584#ent", "<e2>"], "h": {"id": "C0234533", "name": "C0234533#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [14, 15]}}
{"token": ["Other", "complications", "include", "protein-energy", "malnutrition", "C0041296#ent", "<e1>", ",", "croup", ",", "keratopathy", ",", "otitis", "media", "heart", "failure", "C0264558#ent", "<e2>"], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0264558", "name": "C0264558#ent", "pos": [16, 17]}}
{"token": ["Microinjection", "of", "the", "cholinoceptor", "agonist", "carbachol", ",", "the", "C0008425#ent", "<e1>", "physostigmine", "and", "the", "C0242900#ent", "<e2>", "the", "PHN", "caused", "increases", "in", "firing", "rate", "of", "AHA", "angiotensin-II-sensitive", "neurons", "in", "anesthetized", "WKY", "and", "SHR", "."], "h": {"id": "C0008425", "name": "C0008425#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242900", "name": "C0242900#ent", "pos": [13, 14]}}
{"token": ["The", "conservative", "treatment", "C0037384#ent", "<e1>", "encompasses", "weight", "loss", "alcohol", "and", "C0020592#ent", "<e2>", "avoidance", ",", "as", "well", "as", "smoking", "cessation"], "h": {"id": "C0037384", "name": "C0037384#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [10, 11]}}
{"token": ["Chromosome", "in", "situ", "hybridizations", "demonstrated", "that", "the", "PBX", "C0017337#ent", "<e1>", "are", "not", "clustered", "but", "map", "to", "separate", "chromosomal", "loci", "C1418285#ent", "<e2>", ",", "1q23", ";", "PBX2", ",", "3q22", "-", "23", ";", "PBX3", ",", "9q33-34"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418285", "name": "C1418285#ent", "pos": [19, 20]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "determine", "if", "prepartum", "PRL", "or", "C3537453#ent", "<e1>", "supplementation", "would", "override", "the", "HG-induced", "repression", "of", "C1706337#ent", "<e2>", "along", "with", "lipogenic", "genes", "increase", "tissue", "fatty", "acid", "synthesis", "."], "h": {"id": "C3537453", "name": "C3537453#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706337", "name": "C1706337#ent", "pos": [21, 22]}}
{"token": ["One", "hundred", "percent", "of", "patients", "with", "neuroborreliosis", "(", "C1705347#ent", "<e1>", ")", "and", "93", "%", "of", "patients", "with", "C0242381#ent", "<e2>", "LA", ")", "reacted", "positively", "."], "h": {"id": "C1705347", "name": "C1705347#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242381", "name": "C0242381#ent", "pos": [17, 18]}}
{"token": ["Toluene", "diisocyanate", "TDI", ")", "causes", "occupational", "asthma", "characterized", "by", "inflammation", "and", "C0085129#ent", "<e1>", "of", "airways", "to", "irritants", "and", "C0079044#ent", "<e2>"], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0079044", "name": "C0079044#ent", "pos": [18, 19]}}
{"token": ["In", "spinalised", "animals", ",", "C0079246#ent", "<e1>", "selectively", "reduced", "late", "reflexes", "and", "the", "C0027410#ent", "<e2>", "100", "microg", "i.t", ".", ")"], "h": {"id": "C0079246", "name": "C0079246#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027410", "name": "C0027410#ent", "pos": [12, 13]}}
{"token": ["If", "we", "can", "clarify", "the", "regulatory", "mechanism", "the", "C1413376#ent", "<e1>", "this", "will", "lead", "us", "to", "the", "molecular", "pathogenesis", "C2931257#ent", "<e2>"], "h": {"id": "C1413376", "name": "C1413376#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2931257", "name": "C2931257#ent", "pos": [18, 19]}}
{"token": ["The", "Jarisch-Herxheimer", "reaction", "an", "acute", "worsening", "of", "C0037285#ent", "<e1>", "systemic", "symptoms", "after", "administration", "of", "C1136254#ent", "<e2>", "spirochetal", "infections"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1136254", "name": "C1136254#ent", "pos": [14, 15]}}
{"token": ["C1446659#ent", "<e1>", "definitely", "is", "present", "also", "in", "C3469646#ent", "<e2>", "tangles", "and", "possibly", "in", "Pick", "bodies", "not", "in", "Lewy", "bodies"], "h": {"id": "C1446659", "name": "C1446659#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3469646", "name": "C3469646#ent", "pos": [7, 8]}}
{"token": ["We", "hypothesized", "that", "variations", "in", "C1571622#ent", "<e1>", "gene", "polymorphisms", "the", "risk", "of", "developing", "C0035220#ent", "<e2>", "ARDS", ")", "."], "h": {"id": "C1571622", "name": "C1571622#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035220", "name": "C0035220#ent", "pos": [13, 14]}}
{"token": ["Accumulating", "evidence", "demonstrates", "a", "critical", "involvement", "of", "C0032143#ent", "<e1>", "tPA", ")", "in", "pathological", "and", "physiological", "C0006111#ent", "<e2>"], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0006111", "name": "C0006111#ent", "pos": [15, 16]}}
{"token": ["Penetration", "studies", "have", "revealed", "that", "when", "C1413933#ent", "<e1>", "is", "injected", "under", "DPPC", "C0872351#ent", "<e2>", "compressed", "to", "different", "surface", "pressures", ",", "it", "penetrates", "into", "the", "lipid", "monolayer", "an", "increase", "in", "the", "surface", "pressure"], "h": {"id": "C1413933", "name": "C1413933#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [12, 13]}}
{"token": ["Post-venous", "occlusion", "values", "for", "C0267964#ent", "<e1>", "in", "the", "C0770893#ent", "<e2>", "treated", "patients", "were", "increased", "at", "3", "weeks", "(", "p", "less", "than", "0.05", ")", "although", "there", "was", "no", "difference", "at", "6", "weeks", "."], "h": {"id": "C0267964", "name": "C0267964#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [8, 9]}}
{"token": ["We", "have", "previously", "shown", "that", "C0286651#ent", "<e1>", "attenuates", "lethal", "reperfusion-induced", "injury", "activation", "of", "the", "phosphatidyl", "inositol", "3-kinase", "C1709402#ent", "<e2>", "prosurvival", "signaling", "pathway"], "h": {"id": "C0286651", "name": "C0286651#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1709402", "name": "C1709402#ent", "pos": [17, 18]}}
{"token": ["Coronary", "heart", "disease", "CHD", ")", ",", "cerebrovascular", "disease(CVD)", "and", "C1306889#ent", "<e1>", "are", "three", "main", "life-threatening", "macrovascular", "complications", "in", "C0011847#ent", "<e2>", "."], "h": {"id": "C1306889", "name": "C1306889#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [18, 19]}}
{"token": ["Waardenburg", "syndrome", "type", "I", "C1705528#ent", "<e1>", ")", "is", "an", "autosomal", "dominant", "disorder", "by", "C0018784#ent", "<e2>", "pigmental", "abnormalities", "the", "eye", ",", "hair", "and", "skin", ",", "and", "dystopia", "canthorum"], "h": {"id": "C1705528", "name": "C1705528#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [13, 14]}}
{"token": ["In", "vertebrates", ",", "the", "alpha-tropomyosin", "gene", "Tpm-1", ",", "codes", "for", "at", "least", "9", "C1420872#ent", "<e1>", "isoforms", "that", "are", "expressed", "by", "C1420295#ent", "<e2>", "alternative", "splicing", "."], "h": {"id": "C1420872", "name": "C1420872#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [20, 21]}}
{"token": ["The", "different", "diagnoses", "studied", "were", "bacterial", "meningitis", "pneumonia", ",", "viral", "meningitis", "C0006105#ent", "<e1>", "enteritis", ",", "erysipelas", ",", "viral", "encephalitis", "C0752235#ent", "<e2>", "."], "h": {"id": "C0006105", "name": "C0006105#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0752235", "name": "C0752235#ent", "pos": [19, 20]}}
{"token": ["Pharmacological", "effects", "C0356649#ent", "<e1>", "ritodrine", ")", ",", "a", "C0001640#ent", "<e2>", "were", "investigated", "in", "comparison", "with", "that", "of", "isoxsuprine", "hydrochloride", "isoxsuprine", ")", "on", "the", "motor", "nervous", "system", "the", "central", "nervous", "system"], "h": {"id": "C0356649", "name": "C0356649#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [8, 9]}}
{"token": ["We", "report", "a", "case", "of", "C0031019#ent", "<e1>", "cardiac", "tamponade", "to", "intrapericardial", "rupture", "an", "C0002444#ent", "<e2>", "liver", "abscess"], "h": {"id": "C0031019", "name": "C0031019#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002444", "name": "C0002444#ent", "pos": [13, 14]}}
{"token": ["We", "recommend", "a", "trial", "of", "C0004057#ent", "<e1>", "adjunctive", "therapy", "intractable", "cases", "of", "C0009773#ent", "<e2>"], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009773", "name": "C0009773#ent", "pos": [12, 13]}}
{"token": ["Sel1l", ",", "Nfic", ",", "C1414061#ent", "<e1>", ",", "GATA6", ",", "and", "some", "novel", "C1417679#ent", "<e2>", "were", "found", "differentially", "expressed", ",", "which", "were", "strongly", "related", "the", "tooth", "root", "."], "h": {"id": "C1414061", "name": "C1414061#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["No", "statistically", "significant", "associations", "were", "found", "when", "patients", "without", "C0342245#ent", "<e1>", "with", "other", "categories", "of", "C0015397#ent", "<e2>", "compared", "to", "controls", "."], "h": {"id": "C0342245", "name": "C0342245#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0015397", "name": "C0015397#ent", "pos": [15, 16]}}
{"token": ["These", "findings", "suggest", "that", "C2936882#ent", "<e1>", "can", "exert", "neuroprotective", "effects", "a", "model", "of", "C0085543#ent", "<e2>", "in", "the", "absence", "of", "anti-epileptic", "properties", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [13, 14]}}
{"token": ["By", "using", "antibodies", "specific", "for", "C1378702#ent", "<e1>", "enzymes", "and", "C0298987#ent", "<e2>", ",", "respectively", ",", "immunoreactive", "bands", ",", "which", "differed", "slightly", "in", "mobility", "from", "corresponding", "standards", ",", "were", "detectable", "."], "h": {"id": "C1378702", "name": "C1378702#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0298987", "name": "C0298987#ent", "pos": [9, 10]}}
{"token": ["Immunoblot", "analysis", "that", "C4084713#ent", "<e1>", "and", "not", "cGK", "I", "was", "present", "in", "freshly", "isolated", "C3810553#ent", "<e2>", "and", "CCD", "but", "underwent", "a", "complete", "down-regulation", "during", "the", "primary", "cell", "culture"], "h": {"id": "C4084713", "name": "C4084713#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3810553", "name": "C3810553#ent", "pos": [14, 15]}}
{"token": ["An", "anti-glucosyltransferase", "serum", "prepared", "against", "a", "pure", "enzyme", "preparation", "from", "Streptococcus", "sanguis", "C0028978#ent", "<e1>", "9", ",", "which", "synthesized", "both", "soluble", "and", "insoluble", "C0086140#ent", "<e2>", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [22, 23]}}
{"token": ["In", "conclusion", ",", "our", "data", "suggest", "that", "insulin", "and", "TNF", "alpha", "regulate", "the", "expression", "of", "C1705360#ent", "<e1>", "via", "a", "PI3K-", "and", "C1370600#ent", "<e2>", "1/2-dependent", "pathway", "in", "3T3-L1", "adipocytes", "."], "h": {"id": "C1705360", "name": "C1705360#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [21, 22]}}
{"token": ["C1425141#ent", "<e1>", "was", "tested", "for", "kinase", "activity", "a", "variety", "of", "C0086376#ent", "<e2>", "and", "peptides", "known", "to", "be", "substrates", "for", "either", "mammalian", "protein-serine/threonine", "or", "protein-tyrosine", "kinases", "was", "found", "to", "phosphorylate", "serine/threonine", "residues", "in", "vitro"], "h": {"id": "C1425141", "name": "C1425141#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [10, 11]}}
{"token": ["Methylobacterium", "extorquens", "C1335808#ent", "<e1>", "possesses", "a", "formaldehyde-oxidation", "pathway", "that", "involves", "C0014442#ent", "<e2>", "with", "high", "sequence", "with", "C0014442#ent", "<e2>", "from", "methanogenic", "and", "sulfate-reducing", "archaea", "."], "h": {"id": "C1335808", "name": "C1335808#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}}
{"token": ["In", "both", "types", "of", "C0011849#ent", "<e1>", ",", "hypertension", "is", "involved", "in", "fast", "progress", "C3534591#ent", "<e2>"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [4, 5]}, "relation": "related_to", "t": {"id": "C3534591", "name": "C3534591#ent", "pos": [13, 14]}}
{"token": ["Our", "studies", "indicate", "that", "C1710463#ent", "<e1>", "the", "somatostatin", "gene", "cAMP", "requires", "C0033640#ent", "<e2>", "activity", "and", "may", "depend", "upon", "a", "highly", "conserved", "promoter", "element"], "h": {"id": "C1710463", "name": "C1710463#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [11, 12]}}
{"token": ["C1415804#ent", "<e1>", "KO", "showed", "selective", "decreases", "in", "C0086376#ent", "<e2>", "mu-opioid", "receptors", "the", "paraventricular", "thalamic", "nucleus", "and", "to", "GABAB", "receptors", "the", "basolateral", "nucleus", "of", "amygdala", "."], "h": {"id": "C1415804", "name": "C1415804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [7, 8]}}
{"token": ["Responses", "of", "C1413237#ent", "<e1>", "to", "alternative", "levels", "of", "forage", "allowance", "(", "C3469521#ent", "<e2>", ")", "were", "summarized", "by", "a", "quadratic", "function", "and", "the", "associated", "gains/hectare", "were", "calculated", "."], "h": {"id": "C1413237", "name": "C1413237#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3469521", "name": "C3469521#ent", "pos": [11, 12]}}
{"token": ["In", "electroblots", "both", "calcium-dependent", "and", "-independent", "serum", "C2347054#ent", "<e1>", "radioiodinated", "mannan", "and", "C0002272#ent", "<e2>", "in", "the", "presence", "of", "calcium", "ions", "but", "the", "binding", "of", "calcium-dependent", "serum", "C2347054#ent", "<e1>", "abolished", "by", "EDTA", "."], "h": {"id": "C2347054", "name": "C2347054#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [12, 13]}}
{"token": ["C3539791#ent", "<e1>", "binds", "to", "RBP", "with", "high", "affinity", "and", "has", "robust", "C2825076#ent", "<e2>", "uptake", "activity", "from", "the", "vitamin", "A-RBP", "complex", "."], "h": {"id": "C3539791", "name": "C3539791#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2825076", "name": "C2825076#ent", "pos": [11, 12]}}
{"token": ["This", "implies", "that", "prophylactic", "C0012544#ent", "<e1>", "alone", "would", "be", "unlikely", "to", "reduce", "the", "incidence", "of", "C0037926#ent", "<e2>"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037926", "name": "C0037926#ent", "pos": [15, 16]}}
{"token": ["Renal", "disease", "rare", "in", "children", "with", "juvenile", "idiopathic", "arthritis", "although", "a", "number", "of", "associated", "C0078911#ent", "<e1>", "have", "been", "described", ",", "including", "C0221238#ent", "<e2>"], "h": {"id": "C0078911", "name": "C0078911#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0221238", "name": "C0221238#ent", "pos": [21, 22]}}
{"token": ["The", "effect", "of", "C0028116#ent", "<e1>", ",", "a", "new", "calcium", "antagonist", "on", "rats", "with", "C0020538#ent", "<e2>", "evaluated", "."], "h": {"id": "C0028116", "name": "C0028116#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020538", "name": "C0020538#ent", "pos": [13, 14]}}
{"token": ["Adrenal", "hormones", "modulate", "this", "C1951340#ent", "<e1>", ",", "since", "adrenalectomized", "animals", "responded", "to", "PAF-acether", "with", "exacerbated", "C1839163#ent", "<e2>", "."], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1839163", "name": "C1839163#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "in", "a", "C0018802#ent", "<e1>", "population", "receiving", "high-dose", "ACE", "inhibitor", "background", "therapy", "beta-blockade", "with", "C0004147#ent", "<e2>", "produced", "additional", "benefit", "by", "reversing", "left", "ventricular", "dysfunction"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0004147", "name": "C0004147#ent", "pos": [15, 16]}}
{"token": ["Erythrocyte", "delta-aminolaevulinic", "acid", "dehydratase", "ALAD", ")", "activity", "was", "estimated", "in", "C0341439#ent", "<e1>", "correlated", "with", "some", "tests", "of", "liver", "function", "compared", "with", "enzyme", "activity", "C0341439#ent", "<e1>"], "h": {"id": "C0341439", "name": "C0341439#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0341439", "name": "C0341439#ent", "pos": [10, 11]}}
{"token": ["C1366449#ent", "<e1>", "inhibition", "was", "improved", ":", "the", "most", "potent", "inhibitor", "(", "IC50", "=", "200", "nM", ")", "was", "selective", "towards", "C1366449#ent", "<e1>", "versus", "human", "C0017824#ent", "<e1>", "corresponded", "to", "a", "single", "myristyl", "group", "."], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017824", "name": "C0017824#ent", "pos": [23, 24]}}
{"token": ["Spinocerebellar", "ataxia", "7", "SCA7", ")", "is", "a", "neurodegenerative", "disease", "by", "the", "association", "of", "C0007758#ent", "<e1>", ",", "in", "most", "patients", ",", "progressive", "C0024437#ent", "<e2>", "to", "loss", "of", "autonomy", "blindness", "."], "h": {"id": "C0007758", "name": "C0007758#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0024437", "name": "C0024437#ent", "pos": [21, 22]}}
{"token": ["The", "C0919528#ent", "<e1>", "genomic", "disruption", "detected", "by", "Southern", "blot", "the", "RT-PCR", "for", "the", "C3274678#ent", "<e2>", "chimeric", "transcript", "expression", "are", "molecular", "evidence", "this", "chromosomal", "translocation"], "h": {"id": "C0919528", "name": "C0919528#ent", "pos": [1, 2]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274678", "name": "C3274678#ent", "pos": [13, 14]}}
{"token": ["MDA-7/IL-24", "inhibited", "migration", "and", "invasion", "by", "down-regulating", "the", "production", "of", "C2936824#ent", "<e1>", "focal", "adhesion", "kinase", "and", "matrix", "metalloproteinase-2", "-9", "relative", "to", "C1823521#ent", "<e2>", "and", "Ad-Luc", "."], "h": {"id": "C2936824", "name": "C2936824#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [21, 22]}}
{"token": ["C0033788#ent", "<e1>", "the", "most", "effective", "to", "induce", "apoptosis", ",", "followed", "by", "C0020725#ent", "<e2>", "ML", "I", "while", "the", "viscotoxins", "and", "oligosaccharides", "from", "VAL", "did", "not", "."], "h": {"id": "C0033788", "name": "C0033788#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0020725", "name": "C0020725#ent", "pos": [11, 12]}}
{"token": ["CEACAM1", "(", "also", "known", "as", "C1413306#ent", "<e1>", "C-CAM", "or", "CD66a", ")", "is", "a", "cell", "adhesion", "molecule", "the", "C1334163#ent", "<e2>", "as", "a", "tumor", "inhibitory", "protein", "colon", ",", "prostate", ",", "liver", ",", "endometrial", "and", "breast", "cancers"], "h": {"id": "C1413306", "name": "C1413306#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334163", "name": "C1334163#ent", "pos": [17, 18]}}
{"token": ["A", "case", "is", "reported", "of", "chronic", ",", "inadequately", "treated", "tuberculosis", "with", "C0041834#ent", "<e1>", "which", "clinical", "and", "histologic", "lesions", "compatible", "with", "C0085074#ent", "<e2>", "."], "h": {"id": "C0041834", "name": "C0041834#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085074", "name": "C0085074#ent", "pos": [20, 21]}}
{"token": ["Some", "medicines", "with", "a", "systemic", "aim", "have", "a", "topical", "effect", "aerosol", "administration", "furosemide", ",", "C0546849#ent", "<e1>", ",", "morphine", ",", "interferons", ",", "C0010592#ent", "<e2>", "and", "prostacyclin", "."], "h": {"id": "C0546849", "name": "C0546849#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [21, 22]}}
{"token": ["Despite", "the", "systemic", "nature", "of", "many", "C0035064#ent", "<e1>", "that", "provoke", "C0016382#ent", "<e2>", "the", "erythema", "is", "most", "prominent", "in", "the", "\"", "blush", "area"], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0016382", "name": "C0016382#ent", "pos": [10, 11]}}
{"token": ["However", ",", "co-ligation", "of", "the", "B", "cell", "antigen", "receptor", "FcgammaRIIB", "inhibits", "the", "C1418575#ent", "<e1>", "phosphorylation", "of", "PKB", "and", "ERK1/2", "in", "response", "to", "C1332817#ent", "<e2>", "."], "h": {"id": "C1418575", "name": "C1418575#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332817", "name": "C1332817#ent", "pos": [22, 23]}}
{"token": ["The", "gap", "around", "the", "implants", "was", "filled", "with", "325", "microg", "OP-1", "in", "130", "mg", "C3282676#ent", "<e1>", "carrier", "(", "OP-1", "device", ")", "or", "C0009325#ent", "<e2>", "or", "left", "empty", "."], "h": {"id": "C3282676", "name": "C3282676#ent", "pos": [14, 15]}, "relation": "has_structural_class", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [22, 23]}}
{"token": ["Testis-specific", "poly(A)", "polymerase", "C1423874#ent", "<e1>", ")", "is", "a", "C1514208#ent", "<e2>", "is", "highly", "expressed", "in", "round", "spermatids"], "h": {"id": "C1423874", "name": "C1423874#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1514208", "name": "C1514208#ent", "pos": [8, 9]}}
{"token": ["This", "report", "presents", "a", "case", "of", "severe", "asthmatic", "attack", "adult", "C0852283#ent", "<e1>", "which", "occurred", "in", "an", "C0004096#ent", "<e2>", "subject", "following", "acute", "short-term", "exposure", "to", "used", "cleaning", "detergents"], "h": {"id": "C0852283", "name": "C0852283#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["We", "report", "the", "case", "of", "a", "55-years", "old", "woman", "with", "SLE", "and", "C3813548#ent", "<e1>", "that", "did", "not", "respond", "to", "high-dose", "methylprednisolone", "C0010592#ent", "<e2>", "and", "double", "filtration", "plasma", "pheresis", "."], "h": {"id": "C3813548", "name": "C3813548#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [21, 22]}}
{"token": ["Trypsin", "inhibitors", "Phaseolus", "lunatus", "Glycine", "max", "C0061824#ent", "<e1>", "and", "alkaloids", "from", "Corydalis", "yanhusuo", "able", "to", "inhibit", "C1955880#ent", "<e2>"], "h": {"id": "C0061824", "name": "C0061824#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1955880", "name": "C1955880#ent", "pos": [16, 17]}}
{"token": ["Several", "signaling", "pathways", "been", "shown", "to", "be", "modulated", "by", "C3538705#ent", "<e1>", ",", "including", "MAP", "kinases", "PKC", "isoforms", ",", "cell-cycle", "regulators", "receptor", "tyrosine", "kinases", "C0534519#ent", "<e2>", "."], "h": {"id": "C3538705", "name": "C3538705#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [23, 24]}}
{"token": ["Northern", "blot", "analysis", "a", "50", "%", "reduction", "of", "C2348722#ent", "<e1>", "mRNA", "in", "C0059037#ent", "<e2>", "brain", "relative", "to", "that", "in", "the", "AF", "and", "PF", "groups", "."], "h": {"id": "C2348722", "name": "C2348722#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [12, 13]}}
{"token": ["Glutathione", "S-transferase", "pull-down", "assays", "used", "to", "examine", "whether", "DTACs", "alter", "the", "interaction", "between", "C1414463#ent", "<e1>", "and", "the", "p160", "coactivator", "C1423730#ent", "<e2>", "."], "h": {"id": "C1414463", "name": "C1414463#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1423730", "name": "C1423730#ent", "pos": [19, 20]}}
{"token": ["Serum", "LLH", "was", "activated", "by", "thiol", "compounds", "C0013618#ent", "<e1>", "and", "strongly", "inhibited", "by", "sulfhydryl", "reagents", "serum", "C1704793#ent", "<e2>", "was", "inhibited", "by", "sulfhydryl", "reagents", "not", "activated", "by", "thiol", "compounds", "C0013618#ent", "<e1>", "."], "h": {"id": "C0013618", "name": "C0013618#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [16, 17]}}
{"token": ["C0031670#ent", "<e1>", "PLD", ")", "and", "C1566685#ent", "<e2>", "PP2C", ")", "both", "play", "a", "role", "in", "mediating", "plant", "responses", "to", "abscisic", "acid", "ABA", ")", "."], "h": {"id": "C0031670", "name": "C0031670#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1566685", "name": "C1566685#ent", "pos": [5, 6]}}
{"token": ["Popular", "ingredients", "include", "C1134558#ent", "<e1>", "vitamins", ",", "minerals", ",", "antioxidants", ",", "C3541394#ent", "<e2>", ",", "hormones", ",", "and", "a", "multitude", "of", "\"", "naturals", "\"", "."], "h": {"id": "C1134558", "name": "C1134558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "high-speed", "stirring", "on", "the", "extraction", "of", "C0053001#ent", "<e1>", "(", "L", ")", "complexes", "into", "C0008232#ent", "<e2>", "was", "examined", "for", "the", "copper(II)/perchlorate", ",", "copper(II)/chloride", "and", "zinc(II)/perchlorate", "systems", "."], "h": {"id": "C0053001", "name": "C0053001#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008232", "name": "C0008232#ent", "pos": [16, 17]}}
{"token": ["Urinary", "protein", "enzyme", "excretion", "was", "measured", "in", "33", "patients", "with", "solid", "tumours", "chemotherapy", "with", "the", "cis-platinum", "analogs", "carboplatin", "C0729066#ent", "<e1>", ",", "CBDCA", ")", "and", "iproplatin", "(", "JM9", ",", "C1420492#ent", "<e2>", ")", "."], "h": {"id": "C0729066", "name": "C0729066#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1420492", "name": "C1420492#ent", "pos": [28, 29]}}
{"token": ["The", "compaction", "process", "increased", "bulk", "density", "(", "g/cm(3", ")", ")", "of", "MSB", ",", "C1705133#ent", "<e1>", ",", "MSSL", "and", "C1704876#ent", "<e2>", "by", "2.9", ",", "1.79", ",", "2.40", "and", "2.26", "times", ",", "respectively", "."], "h": {"id": "C1705133", "name": "C1705133#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704876", "name": "C1704876#ent", "pos": [18, 19]}}
{"token": ["These", "data", "suggest", "that", "C1412131#ent", "<e1>", "negatively", "regulates", "the", "pathogenesis", "of", "C0003850#ent", "<e2>", "and", "that", "glucose-dependent", "suppression", "of", "C1412131#ent", "<e1>", "expression", "may", "promote", "the", "development", "of", "C0003850#ent", "<e2>", "in", "diabetics", "."], "h": {"id": "C1412131", "name": "C1412131#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [11, 12]}}
{"token": ["C0282210#ent", "<e1>", ",", "which", "increases", "cyclic", "AMP", "C-6-cells", ",", "increased", "C0017801#ent", "<e2>", "activity", "."], "h": {"id": "C0282210", "name": "C0282210#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017801", "name": "C0017801#ent", "pos": [10, 11]}}
{"token": ["We", "have", "identified", "three", "CD8+", "DNAase", "I", "hypersensitive", "sites", "C1423814#ent", "<e1>", ")", "located", "upstream", "of", "the", "murine", "C1706438#ent", "<e2>"], "h": {"id": "C1423814", "name": "C1423814#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706438", "name": "C1706438#ent", "pos": [17, 18]}}
{"token": ["The", "Vmax", "of", "C0015278#ent", "<e1>", "also", "decreased", ",", "but", "the", "Km", "of", "this", "C0020289#ent", "<e2>", "was", "not", "affected", "by", "ethanol", "."], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [13, 14]}}
{"token": ["The", "functional", "role", "of", "a", "loop", "region", ",", "highly", "conserved", "among", "C0015278#ent", "<e1>", "and", "other", "C0020289#ent", "<e2>", "also", "includes", "the", "essential", "Trp120", "of", "Aspergillus", "awamori", "is", "investigated", "."], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020289", "name": "C0020289#ent", "pos": [15, 16]}}
{"token": ["Proximal", "muscles", "were", "usually", "more", "affected", "than", "distal", ",", "leading", "to", "a", "'", "C0686353#ent", "<e1>", "of", "weakness", ";", "although", "C0033377#ent", "<e2>", "was", "often", "present", "from", "an", "early", "age", "eye", "movements", "rarely", "involved", "."], "h": {"id": "C0686353", "name": "C0686353#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033377", "name": "C0033377#ent", "pos": [19, 20]}}
{"token": ["The", "gene", "XYL1", "encoding", "a", "C0057072#ent", "<e1>", "from", "Pichia", "stipitis", "transformed", "into", "a", "mutant", "of", "Saccharomyces", "cerevisiae", "of", "C0017868#ent", "<e2>", "production", "because", "of", "deletion", "of", "the", "genes", "GPD1", "and", "GPD2", "."], "h": {"id": "C0057072", "name": "C0057072#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [18, 19]}}
{"token": ["The", "peroxisome", "proliferator-activated", "receptor", "gamma", "PPARgamma", ")", "ligand", "C1257987#ent", "<e1>", "was", "found", "to", "activate", "the", "C1418945#ent", "<e2>", "promoter", "in", "colon", "cancer", "cells"], "h": {"id": "C1257987", "name": "C1257987#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418945", "name": "C1418945#ent", "pos": [15, 16]}}
{"token": ["Levosimendan", "has", "a", "more", "beneficial", "profile", "than", "C0600487#ent", "<e1>", "regarding", "the", "development", "of", "ventricular", "arrhythmias", "and", "after", "C0010054#ent", "<e2>"], "h": {"id": "C0600487", "name": "C0600487#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [17, 18]}}
{"token": ["This", "trend", "towards", "oxygen", "imbalance", "suggests", "the", "need", "for", "caution", "in", "the", "use", "of", "C0600487#ent", "<e1>", "in", "patients", "with", "severe", "C0010054#ent", "<e2>"], "h": {"id": "C0600487", "name": "C0600487#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [20, 21]}}
{"token": ["Co-immunoprecipitation", "experiments", "showed", "that", "C1416526#ent", "<e1>", "bound", "to", "C1418821#ent", "<e2>", "in", "transfected", "HEK-293", "cells", "."], "h": {"id": "C1416526", "name": "C1416526#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418821", "name": "C1418821#ent", "pos": [8, 9]}}
{"token": ["A", "62-year-old", "patient", "with", "low", "grade", "fever", "fatigue", ",", "C0019559#ent", "<e1>", "and", "newly", "discovered", "mitral", "regurgitation", "diagnosed", "with", "C0264863#ent", "<e2>"], "h": {"id": "C0019559", "name": "C0019559#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0264863", "name": "C0264863#ent", "pos": [18, 19]}}
{"token": ["The", "changes", "in", "serum", "lipids", "men", "treated", "with", "C0017245#ent", "<e1>", "in", "the", "Helsinki", "Heart", "Study", ",", "a", "controlled", "primary", "prevention", "trial", "C1956346#ent", "<e2>", "varied", "according", "to", "baseline", "lipid", "levels", "type", "of", "dyslipidaemia", "and", "treatment", "compliance"], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [8, 9]}, "relation": "may_prevent", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [21, 22]}}
{"token": ["Attenuated", "forces", "transmitted", "to", "the", "spine", "through", "the", "C0023222#ent", "<e1>", "while", "additional", "forces", "at", "the", "lumbo-sacral", "junction", "caused", "by", "C0231451#ent", "<e2>", "lateral", "flexion", "twisting", "during", "the", "delivery", "stride"], "h": {"id": "C0023222", "name": "C0023222#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0231451", "name": "C0231451#ent", "pos": [19, 20]}}
{"token": ["The", "specific", "binding", "for", "C0028928#ent", "<e1>", "was", "around", "1.5", "nmol", "per", "mg", "of", "C1334693#ent", "<e2>"], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334693", "name": "C1334693#ent", "pos": [13, 14]}}
{"token": ["We", "also", "describe", "methods", "to", "perform", "in", "vitro", "processing", "reactions", "of", "mitochondrial", "precursors", "recombinant", "C1417248#ent", "<e1>", "and", "to", "identify", "the", "cleavage", "sites", "used", "by", "this", "C0027203#ent", "<e2>", "."], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [25, 26]}}
{"token": ["Fluorescence", "quenching", "analysis", "showed", "that", "the", "peptide", "bound", "to", "C1417248#ent", "<e1>", "was", "buried", "in", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C1417248", "name": "C1417248#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [15, 16]}}
{"token": ["However", ",", "while", "both", "C3540772#ent", "<e1>", "readily", "hydrolysed", "cephaloridine", "and", "showed", "no", "C1332788#ent", "<e2>", "with", "this", "substrate", ",", "they", "only", "conferred", "a", "very", "weak", "protection", "against", "it", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332788", "name": "C1332788#ent", "pos": [12, 13]}}
{"token": ["C0019202#ent", "<e1>", "a", "disorder", "of", "copper", "metabolism", "by", "C0023890#ent", "<e2>", "neuronal", "degeneration", "to", "inherited", "mutations", "in", "a", "gene", "encoding", "a", "putative", "copper-transporting", "P-type", "ATPase"], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [8, 9]}}
{"token": ["To", "analyze", "pituitary", "hormone", "melatonin", "circadian", "rhythms", ",", "and", "to", "correlate", "hormonal", "alterations", "with", "clinical", "performance", "C0019202#ent", "<e1>", "severity", "and", "diagnostic", "tests", "for", "the", "detection", "of", "hepatic", "encephalopathy", "C0023890#ent", "<e2>", "."], "h": {"id": "C0019202", "name": "C0019202#ent", "pos": [16, 17]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [28, 29]}}
{"token": ["Inhibition", "of", "C1366555#ent", "<e1>", "activity", "by", "C1337110#ent", "<e2>", "may", "enhance", "the", "efficacy", "of", "IFN-alpha", "and", "5-FU", "combination", "therapy", "patients", "with", "HCC", "showing", "resistance", "to", "this", "therapy", "."], "h": {"id": "C1366555", "name": "C1366555#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1337110", "name": "C1337110#ent", "pos": [6, 7]}}
{"token": ["C0149958#ent", "<e1>", "present", "in", "7", "patients", "and", "C0877017#ent", "<e2>", "present", "in", "1", "patient", "."], "h": {"id": "C0149958", "name": "C0149958#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0877017", "name": "C0877017#ent", "pos": [7, 8]}}
{"token": ["Four", "patients", "had", "generalized", "seizures", "two", "patients", "had", "C0149958#ent", "<e1>", "extended", "to", "C0877017#ent", "<e2>"], "h": {"id": "C0149958", "name": "C0149958#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0877017", "name": "C0877017#ent", "pos": [12, 13]}}
{"token": ["There", "were", "positive", "correlations", "between", "the", "C1826536#ent", "<e1>", "and", "pKP", "values", "of", "C0146011#ent", "<e2>", "and", "also", "between", "the", "two", "C1826536#ent", "<e1>", "values", "of", "norepinephrine", "and", "C0146011#ent", "<e2>", "."], "h": {"id": "C0146011", "name": "C0146011#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1826536", "name": "C1826536#ent", "pos": [6, 7]}}
{"token": ["In", "human", "heart", "C1415638#ent", "<e1>", "mRNA", "and", "protein", "was", "significantly", "increased", "in", "individuals", "with", "C0018801#ent", "<e2>", "a", "condition", "associated", "with", "increases", "in", "the", "beta-adrenergic", "receptor", "norepinephrine", "."], "h": {"id": "C1415638", "name": "C1415638#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [14, 15]}}
{"token": ["C0041466#ent", "<e1>", "TF", ")", "is", "a", "severe", "C0009952#ent", "<e2>", "illness", "caused", "by", "Salmonella", "typhi"], "h": {"id": "C0041466", "name": "C0041466#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [7, 8]}}
{"token": ["A", "number", "of", "C0042672#ent", "<e1>", "including", "vincristine", ",", "vinblastine", ",", "and", "C0078257#ent", "<e2>", ",", "are", "currently", "used", "in", "cancer", "chemotherapy"], "h": {"id": "C0042672", "name": "C0042672#ent", "pos": [3, 4]}, "relation": "chemical_structure_of", "t": {"id": "C0078257", "name": "C0078257#ent", "pos": [11, 12]}}
{"token": ["In", "Saccharomyces", "cerevisiae", "the", "P-type", "ATPase", "transports", "C0001477#ent", "<e1>", "Mn(2", "+", ")", "ions", "into", "the", "C1423498#ent", "<e2>", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1423498", "name": "C1423498#ent", "pos": [15, 16]}}
{"token": ["Subsequent", "transfection", "assays", "that", "SHP-1", "and", "C1419105#ent", "<e1>", "are", "the", "two", "principal", "C0255873#ent", "<e2>", "capable", "of", "regulating", "the", "phosphorylation", "state", "of", "the", "TCR", "zeta", "ITAMs", ",", "with", "C1419105#ent", "<e1>", "directly", "dephosphorylating", "zeta"], "h": {"id": "C1419105", "name": "C1419105#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0255873", "name": "C0255873#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", "to", "Arg-gingipain", ",", "C0250557#ent", "<e1>", "was", "not", "inhibited", "by", "hemin", ",", "suggesting", "that", "this", "C0030946#ent", "<e2>", "played", "a", "role", "near", "the", "cell", "surface", "high", "concentrations", "of", "hemin", "confer", "the", "black", "pigmentation"], "h": {"id": "C0250557", "name": "C0250557#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [16, 17]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "identify", "possible", "disease-associated", "mutations", "in", "the", "canine", "C1334043#ent", "<e1>", "of", "the", "polycystic", "kidney", "disease", "gene", "1", "PKD1", ")", "in", "Bull", "Terriers", "autosomal", "dominant", "C3149841#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [30, 31]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "identify", "possible", "disease-associated", "mutations", "in", "the", "canine", "C1334043#ent", "<e1>", "of", "the", "C3149841#ent", "<e2>", "PKD1", ")", "in", "Bull", "Terriers", "autosomal", "dominant", "polycystic", "kidney", "disease"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [18, 19]}}
{"token": ["Sections", "digested", "with", "the", "C0162745#ent", "<e1>", "\"", "V'ase", "\"", ")", "showed", "no", "removal", "of", "C0165519#ent", "<e2>"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [4, 5]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0165519", "name": "C0165519#ent", "pos": [14, 15]}}
{"token": ["Of", "these", "three", "genes", ",", "the", "C0079429#ent", "<e1>", "most", "distal", "to", "GBA", "is", "a", "protein", "kinase", "C1413490#ent", "<e2>", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413490", "name": "C1413490#ent", "pos": [16, 17]}}
{"token": ["The", "calcium-entry", "blocker", "flunarizine", "(", "C0037044#ent", "<e1>", ";", "Janssen", ")", "was", "compared", "with", "the", "C0001645#ent", "<e2>", "propranolol", "in", "the", "prophylaxis", "of", "migraine", "."], "h": {"id": "C0037044", "name": "C0037044#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "how", "the", "renin-angiotensin", "system", "RAS", ")", "might", "be", "involved", "in", "C0003850#ent", "<e1>", "we", "studied", "the", "effects", "of", "nonsulhydryl", "angiotensin", "converting", "enzyme", "(ACE)", "inhibitor", "enalapril", ",", "and", "an", "C0521942#ent", "<e2>", "E-4177", ",", "in", "cholesterol", "fed", "rabbits", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0521942", "name": "C0521942#ent", "pos": [29, 30]}}
{"token": ["Signaling", "endosomes", "travel", "from", "the", "nerve", "terminals", "remote", "cell", "bodies", "where", "they", "selectively", "activate", "a", "novel", "MAP", "kinase", "C1708804#ent", "<e1>", ",", "as", "well", "as", "C0044602#ent", "<e2>", "and", "thereby", "stimulate", "neuronal", "survival"], "h": {"id": "C1708804", "name": "C1708804#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [24, 25]}}
{"token": ["Our", "studies", "also", "indicated", "that", "induction", "of", "C1708266#ent", "<e1>", "expression", "affected", "the", "molecular", "partnership", "C1705813#ent", "<e2>", "and", "translocated", "C1705813#ent", "<e2>", "into", "nuclei", "where", "it", "colocalized", "with", "C1708266#ent", "<e1>", "."], "h": {"id": "C1708266", "name": "C1708266#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705813", "name": "C1705813#ent", "pos": [14, 15]}}
{"token": ["In", "order", "to", "allow", "dose", "intensification", ",", "minimize", "leukopenia", ",", "and", "improve", "efficacy", "granulocyte", "colony-stimulating", "factor", "C1705750#ent", "<e1>", ")", "was", "used", "in", "combination", "with", "C0631180#ent", "<e2>", "and", "etoposide", "."], "h": {"id": "C1705750", "name": "C1705750#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0631180", "name": "C0631180#ent", "pos": [24, 25]}}
{"token": ["A", "comparative", "study", "the", "toxicity", "of", "the", "inotropic", "amines", "isoproterenol", "hydrochloride", "IP", ")", ",", "C0028333#ent", "<e1>", "NE", ")", ",", "dopamine", "hydrochloride", "DP", ")", ",", "and", "C0700450#ent", "<e2>", "DB", ")", "was", "conducted", "in", "beagle", "dogs", "2/sex/dose", "group", ")", "."], "h": {"id": "C0028333", "name": "C0028333#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0700450", "name": "C0700450#ent", "pos": [25, 26]}}
{"token": ["The", "relative", "potencies", "and", "efficacies", "of", "l-isoproterenol", ",", "l-epinephrine", ",", "C0028333#ent", "<e1>", ",", "terbutaline", ",", "and", "C0700450#ent", "<e2>", "for", "physiological", "and", "biochemical", "events", "similar", "."], "h": {"id": "C0028333", "name": "C0028333#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0700450", "name": "C0700450#ent", "pos": [16, 17]}}
{"token": ["C1849508#ent", "<e1>", "a", "rare", "autosomal", "recessive", "disorder", "usually", "presents", "with", "neonatal", "intractable", "C0036572#ent", "<e2>", "."], "h": {"id": "C1849508", "name": "C1849508#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "C1419998#ent", "<e1>", "is", "a", "C0031686#ent", "<e2>", "in", "vivo", "is", "a", "substrate", "for", "CDK11(p110", ")", "phosphorylation", "in", "vitro"], "h": {"id": "C1419998", "name": "C1419998#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [6, 7]}}
{"token": ["A", "model", "was", "presented", "which", "suggested", "the", "presence", "of", "two", "noninteracting", "pools", "of", "enzyme", "or", "C0022173#ent", "<e1>", "which", "exhibit", "either", "a", "high", "or", "low", "affinity", "for", "C0029904#ent", "<e2>", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0029904", "name": "C0029904#ent", "pos": [26, 27]}}
{"token": ["They", "might", "be", "lipids", "(", "e.g.", "slow", "irreversible", "inhibition", "by", "fatty", "acids", "relieved", "by", "serum", "albumin", "or", "C1415142#ent", "<e1>", "RF", "and", "enzymes", "(", "C0030940#ent", "<e2>", "and", "phospholipases", ")", "."], "h": {"id": "C1415142", "name": "C1415142#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [23, 24]}}
{"token": ["We", "treated", "a", "patient", "who", "had", "acquired", "C0004030#ent", "<e1>", "some", "80", "days", "after", "allogeneic", "bone", "marrow", "transplantation", "with", "C0064113#ent", "<e2>", "600", "mg", "daily", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [18, 19]}}
{"token": ["The", "early", "endosomal", "marker", "C1414266#ent", "<e1>", "is", "colocalized", "with", "some", "of", "C1412492#ent", "<e2>", "vesicles", "."], "h": {"id": "C1414266", "name": "C1414266#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412492", "name": "C1412492#ent", "pos": [11, 12]}}
{"token": ["C1333890#ent", "<e1>", "is", "the", "catalytic", "subunit", "the", "only", "C0671924#ent", "<e2>", "(", "HAT-B", ")", "."], "h": {"id": "C1333890", "name": "C1333890#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0671924", "name": "C0671924#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "the", "difference", "between", "two", "types", "of", "C0035305#ent", "<e1>", "postoperative", "visual", "recovery", "in", "the", "management", "of", "C0271055#ent", "<e2>"], "h": {"id": "C0035305", "name": "C0035305#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0271055", "name": "C0271055#ent", "pos": [17, 18]}}
{"token": ["The", "presence", "of", "only", "one", "thiolase", "(", "C1334858#ent", "<e1>", "in", "wild-type", "Escherichia", "coli", "induced", "for", "C3540772#ent", "<e2>", "of", "beta", "oxidation", "demonstrated", "."], "h": {"id": "C1334858", "name": "C1334858#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [15, 16]}}
{"token": ["The", "C1706229#ent", "<e1>", "cultures", "resulted", "in", "a", "microbiologic", "diagnosis", "C0004626#ent", "<e2>", "eight", "patients", "(", "11", "percent", ")", "from", "the", "study", "group", "in", "one", "patient", "(", "8", "percent", ")", "from", "the", "control", "group"], "h": {"id": "C1706229", "name": "C1706229#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004626", "name": "C0004626#ent", "pos": [9, 10]}}
{"token": ["These", "findings", "suggested", "that", "basal", "levels", "C0042071#ent", "<e1>", "secretion", "were", "modulated", "in", "response", "to", "C1333536#ent", "<e2>", "that", "these", "growth", "factors", "also", "have", "mediated", "the", "effect", "of", "UVR", "on", "C0042071#ent", "<e1>", "levels", "."], "h": {"id": "C0042071", "name": "C0042071#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333536", "name": "C1333536#ent", "pos": [14, 15]}}
{"token": ["Free-floating", "adrenal", "gland", "sections", "hybridized", "with", "35S-labeled", "cDNA", "probes", "for", "tyrosine", "hydroxylase", "TH", ")", ",", "dopamine", "beta-hydroxylase", "DBH", ")", ",", "C0031397#ent", "<e1>", "PNMT", ")", ",", "PAM", ",", "and", "C1417815#ent", "<e2>", "."], "h": {"id": "C0031397", "name": "C0031397#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [28, 29]}}
{"token": ["Here", "we", "show", "that", "overexpression", "of", "extracellular", "signal-regulated", "kinase", "1", "C1366765#ent", "<e1>", ")", "cDNA", ",", "encoding", "C4082284#ent", "<e2>", ",", "results", "in", "the", "activation", "of", "Elk-1", ",", "the", "serum", "response", "factor", "accessory", "protein"], "h": {"id": "C1366765", "name": "C1366765#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4082284", "name": "C4082284#ent", "pos": [16, 17]}}
{"token": ["In", "addition", "to", "PDI", "and", "gp96", ",", "previously", "identified", "as", "peptide-binding", "chaperones", "in", "the", "ER", ",", "we", "show", "that", "C1538609#ent", "<e1>", ",", "calnexin", ",", "and", "C1333935#ent", "<e2>", "interact", "with", "TAP-translocated", "peptides", "."], "h": {"id": "C1538609", "name": "C1538609#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1333935", "name": "C1333935#ent", "pos": [25, 26]}}
{"token": ["Tumor-suppressor", "genes", "C0029016#ent", "<e1>", "or", "recessive", "oncogenes", "are", "C0919437#ent", "<e2>", "achieve", "their", "oncogenic", "effect", "by", "mutational", "inactivation", "both", "normal", "alleles"], "h": {"id": "C0029016", "name": "C0029016#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919437", "name": "C0919437#ent", "pos": [8, 9]}}
{"token": ["Acute", "renal", "failure", "C0035436#ent", "<e1>", ")", "is", "a", "common", "complication", "of", "C0036690#ent", "<e2>", "and", "often", "occurs", "as", "a", "component", "of", "multiple", "organ", "dysfunction", "syndrome"], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [11, 12]}}
{"token": ["Oral", "challenge", "tests", "with", "other", "C0003211#ent", "<e1>", ",", "even", "of", "the", "same", "group", "as", "C0068334#ent", "<e2>", ",", "were", "negative", "in", "both", "patients", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0068334", "name": "C0068334#ent", "pos": [14, 15]}}
{"token": ["There", "was", "no", "difference", "in", "the", "C0720099#ent", "<e1>", "of", "phase", "II", "the", "MMC", "cycle", "MM", ",", "C1705457#ent", "<e2>", ",", "and", "LM", "even", "though", "subjects", "were", "asleep", "during", "the", "MMC", "cycles", "after", "LM", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705457", "name": "C1705457#ent", "pos": [16, 17]}}
{"token": ["Although", "C0031392#ent", "<e1>", "shows", "the", "most", "efficacy", "in", "this", "population", ",", "treatment", "with", "TCAs", ",", "C0360105#ent", "<e2>", "cognitive-behavioral", "therapy", "MAOIs", "other", "than", "C0031392#ent", "<e1>", ",", "and", "other", "agents", "are", "discussed", "."], "h": {"id": "C0360105", "name": "C0360105#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0031392", "name": "C0031392#ent", "pos": [1, 2]}}
{"token": ["Importantly", ",", "a", "prerequisite", "to", "C0063083#ent", "<e1>", "is", "that", "the", "C0030956#ent", "<e2>", "must", "first", "fold", "into", "a", "conformation", "conducive", "to", "self-assembly", "."], "h": {"id": "C0063083", "name": "C0063083#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}}
{"token": ["The", "low", "incidence", "has", "been", "sustainable", "due", "to", "these", "interventions", ",", "and", "since", "1994", "C0035921#ent", "<e1>", "rubella", "in", "pregnancy", "have", "been", "listed", "as", "notifiable", "C0009450#ent", "<e2>", "Denmark", "."], "h": {"id": "C0035921", "name": "C0035921#ent", "pos": [14, 15]}, "relation": "has_nichd_parent", "t": {"id": "C0009450", "name": "C0009450#ent", "pos": [24, 25]}}
{"token": ["C0018293#ent", "<e1>", "activity", "increased", "2-fold", "in", "vivo", "C2697656#ent", "<e2>", "."], "h": {"id": "C0018293", "name": "C0018293#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [7, 8]}}
{"token": ["Two", "coenzyme-dependent", "oxidoreductases", ",", "glucose", "dehydrogenase", "C3659502#ent", "<e1>", "were", "immobilized", "in", "polyacrylamide", "gel", "a", "C1171558#ent", "<e2>", "grid", "matrix", "used", "as", "enzyme", "electrodes", "measure", "their", "substrate", "concentrations", "in", "buffered", "aqueous", "solutions", "."], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1171558", "name": "C1171558#ent", "pos": [14, 15]}}
{"token": ["C1414069#ent", "<e1>", "is", "only", "the", "second", "C3272493#ent", "<e2>", "factor", "shown", "to", "influence", "carriage", "of", "the", "bacteria", "in", "the", "bovine", "intestine"], "h": {"id": "C1414069", "name": "C1414069#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272493", "name": "C3272493#ent", "pos": [6, 7]}}
{"token": ["The", "incorporation", "of", "C0028928#ent", "<e1>", "was", "dependent", "upon", "ATP", "and", "coenzyme", "A", "and", "C0050691#ent", "<e2>", "activities", "were", "demonstrated", "in", "N1", "and", "P3", "(", "specific", "activity", "ratio", "N1:P3", "=", "4.5", ")", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0050691", "name": "C0050691#ent", "pos": [13, 14]}}
{"token": ["Coincident", "expression", "of", "Robo1", "with", "C1420245#ent", "<e1>", "in", "the", "metanephric", "mesenchyme", "Robo2", ",", "C1420244#ent", "<e2>", "and", "Slit3", "in", "the", "far", "proximal", "end", "of", "the", "S-shaped", "bodies", "observed", "during", "metanephric", "development"], "h": {"id": "C1420245", "name": "C1420245#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420244", "name": "C1420244#ent", "pos": [13, 14]}}
{"token": ["Suppression", "of", "erythroid", "maturation", "by", "C1335222#ent", "<e1>", "did", "not", "result", "from", "down-regulation", "of", "C1333663#ent", "<e2>", "and", "TAL-1", ",", "transcription", "factors", "for", "erythroid", "differentiation", "."], "h": {"id": "C1335222", "name": "C1335222#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333663", "name": "C1333663#ent", "pos": [13, 14]}}
{"token": ["An", "important", "difference", "between", "the", "activities", "of", "the", "C3265462#ent", "<e1>", "and", "the", "C1334397#ent", "<e2>", "was", "that", "the", "former", "was", "active", "on", "denatured", "tubulin", "whereas", "the", "latter", "was", "not", "."], "h": {"id": "C3265462", "name": "C3265462#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334397", "name": "C1334397#ent", "pos": [12, 13]}}
{"token": ["Both", "the", "C1335440#ent", "<e1>", "and", "the", "C1335439#ent", "<e2>", "enzymes", "are", "active", "components", "the", "structure", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [2, 3]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1335439", "name": "C1335439#ent", "pos": [6, 7]}}
{"token": ["The", "two", "disconnect", "systems", "were", "identical", "in", "principle", ",", "except", "that", "Twinbag", "used", "C0885449#ent", "<e1>", "as", "disinfectant", "of", "connections", "and", "Gemini", "used", "C0001975#ent", "<e2>", "as", "disinfectant", "."], "h": {"id": "C0885449", "name": "C0885449#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [22, 23]}}
{"token": ["The", "C3714952#ent", "<e1>", "three", "ankyrin", "domains", "a", "sterile", "alpha", "motif", "and", "its", "C-terminal", "tripeptide", "a", "class", "I", "C1538117#ent", "<e2>"], "h": {"id": "C3714952", "name": "C3714952#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1538117", "name": "C1538117#ent", "pos": [17, 18]}}
{"token": ["When", "male", "Sprague-Dawley", "rats", "treated", "with", "daily", "intragastric", "dose", "C0057188#ent", "<e1>", "(", "200", "mg.kg-1", ")", "for", "3", "d", ",", "the", "C0059735#ent", "<e2>", "P-450", "2B1", "protein", "levels", "were", "markedly", "increased", "."], "h": {"id": "C0057188", "name": "C0057188#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [20, 21]}}
{"token": ["C0057188#ent", "<e1>", "induced", "rat", "C0059735#ent", "<e2>", "IIB1", "and", "glutathione", "S-transferase", "activities"], "h": {"id": "C0057188", "name": "C0057188#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [4, 5]}}
{"token": ["Other", "investigational", "agents", "may", "play", "a", "role", "in", "treatment", "of", "patients", "resistant", "to", "conventional", "drugs", "include", "C0029276#ent", "<e1>", "(", "a", "vasopressin", "analogue", "and", "C1417807#ent", "<e2>"], "h": {"id": "C0029276", "name": "C0029276#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [23, 24]}}
{"token": ["The", "C1539479#ent", "<e1>", "in", "vivo", "topically", "applied", "1,8-dihydroxy-9-anthrone", "(", "C0003166#ent", "<e2>", ",", "anthralin", ")", "was", "investigated", "in", "the", "skin", "of", "the", "hairless", "rat", ",", "using", "a", "specially", "designed", "drug", "delivery", "system", "film", ")", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003166", "name": "C0003166#ent", "pos": [9, 10]}}
{"token": ["The", "C1539479#ent", "<e1>", "in", "vivo", "topically", "applied", "C0003166#ent", "<e2>", "(", "dithranol", ",", "anthralin", ")", "was", "investigated", "in", "the", "skin", "of", "the", "hairless", "rat", ",", "using", "a", "specially", "designed", "drug", "delivery", "system", "film", ")", "."], "h": {"id": "C1539479", "name": "C1539479#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003166", "name": "C0003166#ent", "pos": [7, 8]}}
{"token": ["Xanthine", "allows", "both", "genotypes", "to", "grow", "in", "the", "presence", "of", "C2347126#ent", "<e1>", "whereas", "guanine", "only", "allows", "growth", "of", "C1442521#ent", "<e2>"], "h": {"id": "C2347126", "name": "C2347126#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [18, 19]}}
{"token": ["This", "increment", "of", "both", "TNF-alpha", "and", "nitrate", "levels", "was", "significantly", "reduced", "in", "C2697656#ent", "<e1>", "rats", "pretreated", "with", "C1706000#ent", "<e2>", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706000", "name": "C1706000#ent", "pos": [17, 18]}}
{"token": ["The", "typical", "presentation", "is", "severe", "sore", "throat", "with", "C0011168#ent", "<e1>", "fever", "and", "C0013404#ent", "<e2>", ".--"], "h": {"id": "C0011168", "name": "C0011168#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013404", "name": "C0013404#ent", "pos": [12, 13]}}
{"token": ["There", "is", ",", "thus", ",", "no", "direct", "evidence", "that", "C0003451#ent", "<e1>", "involved", "in", "the", "aetiology", "of", "C1414860#ent", "<e2>", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414860", "name": "C1414860#ent", "pos": [16, 17]}}
{"token": ["Our", "findings", "suggest", "that", "C1418406#ent", "<e1>", "may", "function", "as", "a", "C1413043#ent", "<e2>", "+", "-dependent", "accessory", "protein", "the", "endosomal", "sorting", "machinery", "by", "interacting", "directly", "with", "TSG101", "as", "well", "as", "with", "Alix", "."], "h": {"id": "C1418406", "name": "C1418406#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [10, 11]}}
{"token": ["C1418406#ent", "<e1>", "(", "apoptosis-linked", "gene", "2", "is", "a", "C1413043#ent", "<e2>", "+", "-binding", "protein", "that", "belongs", "to", "the", "PEF", "(", "penta-EF-hand", ")", "protein", "family"], "h": {"id": "C1418406", "name": "C1418406#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [8, 9]}}
{"token": ["When", "Kringle", "domains", "C0036734#ent", "<e1>", "a", "Kunitz-type", "protease", "inhibitor", "domain", "the", "C0085151#ent", "<e2>", "Alzheimer's", "disease", "patients", "were", "examined", "by", "the", "molecular", "evolutionary", "analysis", "the", "phylogenetic", "trees", "constructed", "showed", "that", "these", "functional", "domains", "undergone", "dynamic", "changes", "in", "the", "evolutionary", "process", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [11, 12]}}
{"token": ["3", "The", "addition", "of", "captopril", "of", "C0020261#ent", "<e1>", "blunted", "the", "hypokalaemia", "and", "C0740394#ent", "<e2>", "observed", "with", "C0020261#ent", "<e1>", "alone", "in", "addition", "to", "its", "antihypertensive", "synergy"], "h": {"id": "C0740394", "name": "C0740394#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020261", "name": "C0020261#ent", "pos": [6, 7]}}
{"token": ["Identification", "of", "the", "newly", "synthesised", "C0086376#ent", "<e1>", "which", "are", "required", "for", "C0962754#ent", "<e2>", "mRNA", "induction", "would", "greatly", "advance", "our", "understanding", "of", "collagenase", "gene", "expression", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [11, 12]}}
{"token": ["As", "for", "p35", ",", "cleavage", "of", "C1705378#ent", "<e1>", "is", "required", "for", "C0010656#ent", "<e2>", "inhibition", "."], "h": {"id": "C1705378", "name": "C1705378#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [11, 12]}}
{"token": ["The", "increase", "in", "the", "activity", "ratio", "the", "C0031727#ent", "<e1>", "with", "10(-5", ")", "M", "C0031469#ent", "<e2>", "was", "much", "smaller", "than", "that", "produced", "by", "a", "glycogenolytically", "equivalent", "dose", "of", "glucagon", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031469", "name": "C0031469#ent", "pos": [13, 14]}}
{"token": ["Based", "on", "a", "routine", "ultrasonic", "screening", "program", "of", "patients", "suffering", "from", "C0000727#ent", "<e1>", "the", "efficacy", "of", "ultrasonic", "diagnosis", "C0021843#ent", "<e2>", "assessed", "prospectively", "in", "a", "series", "of", "48", "patients", "."], "h": {"id": "C0000727", "name": "C0000727#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0021843", "name": "C0021843#ent", "pos": [18, 19]}}
{"token": ["In", "this", "study", ",", "we", "investigated", "hydrogen", "peroxide-dependent", "oxidation", "of", "six", "C0304370#ent", "<e1>", "by", "purified", "lipoxygenase", "from", "C0947608#ent", "<e2>", "(", "SLO", ")", "and", "human", "term", "placenta", "(", "HTPLO", ")", "."], "h": {"id": "C0304370", "name": "C0304370#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0947608", "name": "C0947608#ent", "pos": [17, 18]}}
{"token": ["For", "several", "years", ",", "interferon", "alpha-1", "also", "known", "as", "interferon", "alpha-D", "has", "been", "studied", "for", "treatment", "of", "various", "C0042769#ent", "<e1>", "such", "as", "hepatic", "fibrosis", "by", "hepatitis", "B", "herpes", "simplex", "virus", "keratitis", "and", "C0035242#ent", "<e2>", "calves", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0035242", "name": "C0035242#ent", "pos": [32, 33]}}
{"token": ["When", "treatment", "with", "C0012022#ent", "<e1>", "and", "somatostatin", "for", "persistent", "hyperinsulinaemic", "C0020615#ent", "<e2>", "of", "infancy", "failed", ",", "subtotal", "pancreatectomy", "performed", "on", "a", "neonate", "on", "day", "41", "."], "h": {"id": "C0012022", "name": "C0012022#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [10, 11]}}
{"token": ["RES", "cells", "produced", "comparable", "amounts", "of", "nitrite/nitrate", "in", "response", "to", "C0243192#ent", "<e1>", "treatment", "but", "showed", "no", "apoptotic", "markers", "i.e.", "chromatin", "condensation", "C1705526#ent", "<e2>", "accumulation", "."], "h": {"id": "C0243192", "name": "C0243192#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [21, 22]}}
{"token": ["Simultaneous", "C0009450#ent", "<e1>", "of", "purified", "B", "cells", "EBV", "and", "C0019693#ent", "<e2>", "resulted", "in", "a", "marked", "reduction", "of", "C0019693#ent", "<e2>", "expression", ",", "whereas", "EBV-induced", "transformation", "enhanced", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [9, 10]}}
{"token": ["Possible", "implications", "of", "the", "interaction", "of", "HMG1", "and", "C1333909#ent", "<e1>", "histones", "for", "the", "structure", "and", "functioning", "of", "C0008546#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C1333909", "name": "C1333909#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [17, 18]}}
{"token": ["Presection", "of", "the", "vagus", "at", "the", "neck", "level", "prevented", "the", "development", "of", "bradycardia", "and", "accelerated", "the", "formation", "of", "C0020538#ent", "<e1>", "administration", "of", "C0022471#ent", "<e2>", "the", "caudal", "ventral", "medulla", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0022471", "name": "C0022471#ent", "pos": [22, 23]}}
{"token": ["This", "study", "delineates", "for", "the", "first", "time", "the", "molecular", "mechanisms", "modulate", "caveolin-1", "C0812327#ent", "<e1>", "oxidative", "stress", "brings", "new", "insights", "into", "the", "redox", "control", "of", "C1423721#ent", "<e2>", "both", "normal", "and", "cancer", "cells"], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1423721", "name": "C1423721#ent", "pos": [24, 25]}}
{"token": ["Because", "C0277794#ent", "<e1>", "is", "a", "protein", "kinase", "C", "PKC", ")", "activator", ",", "we", "next", "examined", "the", "potential", "contribution", "of", "distinct", "C1826724#ent", "<e2>", "isoforms", "to", "down-regulate", "CD4", "and", "CXCR4", "in", "response", "to", "C0277794#ent", "<e1>", "stimulation", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0277794", "name": "C0277794#ent", "pos": [1, 2]}}
{"token": ["However", ",", "in", "contrast", "to", "the", "latter", ",", "C1427812#ent", "<e1>", "is", "a", "constitutively", "C1420084#ent", "<e2>"], "h": {"id": "C1427812", "name": "C1427812#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420084", "name": "C1420084#ent", "pos": [13, 14]}}
{"token": ["As", "proven", "in", "numerous", "clinical", "trials", "C0040259#ent", "<e1>", "be", "effectively", "and", "safely", "treated", "by", "C0076110#ent", "<e2>"], "h": {"id": "C0040259", "name": "C0040259#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [14, 15]}}
{"token": ["In", "the", "management", "of", "C0040259#ent", "<e1>", "a", "cost", "analysis", "that", "initial", "therapy", "with", "C0076110#ent", "<e2>", "1", "%", "cream", "was", "more", "costly", "than", "initial", "therapy", "with", "miconazole", ",", "oxiconazole", "or", "clotrimazole", "."], "h": {"id": "C0040259", "name": "C0040259#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [13, 14]}}
{"token": ["It", "is", "still", "difficult", "to", "directly", "prove", "the", "involvement", "of", "hemodynamic", "ischemia", "C0007787#ent", "<e1>", "patients", "with", "C0003838#ent", "<e2>"], "h": {"id": "C0007787", "name": "C0007787#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003838", "name": "C0003838#ent", "pos": [16, 17]}}
{"token": ["C1420492#ent", "<e1>", "analyses", "showed", "that", "both", "Twist", "and", "C1419771#ent", "<e2>", "in", "mutant", "osteoblast", "nuclear", "extracts", "bind", "to", "a", "specific", "region", "in", "the", "Fgfr2", "promoter", "."], "h": {"id": "C1420492", "name": "C1420492#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [8, 9]}}
{"token": ["The", "direction", "of", "effects", "of", "QTL", "alleles", "and", "a", "coincidence", "between", "the", "behavioral", "profiles", "of", "C0040616#ent", "<e1>", "genetic", "action", "consistent", "with", "QTL", "containing", "at", "least", "one", "C0017337#ent", "<e2>", "with", "a", "pleiotropic", "action", "fear", "responses"], "h": {"id": "C0040616", "name": "C0040616#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [26, 27]}}
{"token": ["In", "eWAT", "obtained", "from", "C1413277#ent", "<e1>", "or", "CAD", "patients", ",", "immunoreactivity", "for", "AM", ",", "C1424497#ent", "<e2>", ",", "and", "RAMP2", "and", "-3", "was", "detected", "in", "blood", "vessel", "walls", "isolated", "stromal", "cells", "to", "adipocytes", "."], "h": {"id": "C1413277", "name": "C1413277#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424497", "name": "C1424497#ent", "pos": [14, 15]}}
{"token": ["C0075616#ent", "<e1>", "sulfide", "treatment", "was", "associated", "with", "activation", "of", "ERKp44/42", "and", "C1705633#ent", "<e2>", "MAPK", "in", "a", "dosage-", "and", "time-dependent", "manner", ",", "and", "also", "activated", "upstream", "MEK", "."], "h": {"id": "C0075616", "name": "C0075616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705633", "name": "C1705633#ent", "pos": [11, 12]}}
{"token": ["We", "propose", "that", "Ttk69", "represses", "some", "target", "C0017337#ent", "<e1>", "by", "remodelling", "chromatin", "structure", "the", "recruitment", "of", "the", "C0960948#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0960948", "name": "C0960948#ent", "pos": [17, 18]}}
{"token": ["However", ",", "full", "inhibition", "of", "translation", "by", "either", "C1254351#ent", "<e1>", "leads", "to", "prolonged", "activation", "of", "SAPK", "activity", ",", "while", "C0752312#ent", "<e2>", "induction", "is", "transient", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [19, 20]}}
{"token": ["The", "recombinant", "Propionibacterium", "ALA", "at", "a", "maximum", "concentration", "of", "8.6", "mM", "in", "the", "absence", "of", "levulinic", "acid", "an", "inhibitor", "of", "C0002564#ent", "<e1>", "with", "1", "%", "glucose", "as", "a", "C0524928#ent", "<e2>", "source", "."], "h": {"id": "C0002564", "name": "C0002564#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [28, 29]}}
{"token": ["The", "AML1-MTG16", "fusion", "protein", "targeted", "to", "the", "nucleoplasm", "where", "it", "is", "capable", "to", "oligomerize", "with", "C3273417#ent", "<e1>", "and", "interact", "with", "HDAC1", "and", "C1098658#ent", "<e2>", "."], "h": {"id": "C3273417", "name": "C3273417#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1098658", "name": "C1098658#ent", "pos": [22, 23]}}
{"token": ["Cytochromes", "P-450", "C1539600#ent", "<e1>", ",", "NADPH", "and", "NADH", "cytochrome", "c", "reductase", "methadone", "and", "meperidine", "N-demethylase", "morphine", "C0311878#ent", "<e2>", "activities", "were", "detected", "in", "microsomes", "from", "both", "maternal", "and", "fetal", "livers", "."], "h": {"id": "C1539600", "name": "C1539600#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0311878", "name": "C0311878#ent", "pos": [16, 17]}}
{"token": ["C2986630#ent", "<e1>", "displayed", "65", "%", "amino", "acid", "sequence", "homology", "with", "human", "C1412726#ent", "<e2>", "(", "hBAT", ")", "and", "85", "%", "homology", "with", "mouse", "C1412726#ent", "<e2>", "(", "mBAT", ")", "."], "h": {"id": "C2986630", "name": "C2986630#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412726", "name": "C1412726#ent", "pos": [11, 12]}}
{"token": ["When", "a", "microsomal", "preparation", "from", "these", "cells", "is", "incubated", "in", "vitro", "C1705556#ent", "<e1>", ",", "the", "principal", "tyrosine", "protein", "kinase", "substrate", "is", "a", "56,000-dalton", "protein", ",", "C1824618#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1824618", "name": "C1824618#ent", "pos": [25, 26]}}
{"token": ["Large", ",", "slowly", "desensitizing", "macroscopic", "currents", "were", "induced", "by", "rapidly", "infusing", "an", "C3536863#ent", "<e1>", "solution", "containing", "50", "microM", "ACh", "in", "the", "presence", "of", "C1161352#ent", "<e2>", "."], "h": {"id": "C3536863", "name": "C3536863#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [23, 24]}}
{"token": ["Clinically", "isolated", "syndromes", "(", "CIS", ")", "classically", "refer", "to", "optic", "neuritis", "C1420342#ent", "<e1>", ")", ",", "brainstem", "or", "C0080218#ent", "<e2>"], "h": {"id": "C1420342", "name": "C1420342#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0080218", "name": "C0080218#ent", "pos": [17, 18]}}
{"token": ["Various", "C3540772#ent", "<e1>", "and", "protein", "reagents", "inhibited", "C0058310#ent", "<e2>", "to", "bovine", "corpus", "cell", "membranes"], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0058310", "name": "C0058310#ent", "pos": [7, 8]}}
{"token": ["The", "discovery", "of", "mis-sense", "mutations", "the", "alpha1A", "subunit", "of", "the", "P/Q-type", "calcium", "channel", "patients", "with", "C0338484#ent", "<e1>", "the", "potential", "involvement", "of", "dysfunctional", "ion", "channels", "C0149931#ent", "<e2>", "."], "h": {"id": "C0338484", "name": "C0338484#ent", "pos": [15, 16]}, "relation": "has_nichd_parent", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [24, 25]}}
{"token": ["2,8-Dihydroxyadeninuria", "is", "a", "rare", "C0025517#ent", "<e1>", "has", "been", "reported", "to", "have", "caused", "C0403719#ent", "<e2>", "in", "14", "cases", ",", "mostly", "children", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0403719", "name": "C0403719#ent", "pos": [12, 13]}}
{"token": ["An", "C2917660#ent", "<e1>", "substitution", "in", "the", "enoyl-ACP", "reductase", "the", "C1826448#ent", "<e2>", "mutant", "causes", "a", "marked", "decrease", "in", "its", "enzymatic", "activity", "impairing", "fatty", "acid", "biosynthesis", "decreasing", "the", "amount", "of", "total", "lipids", "in", "C1826448#ent", "<e2>", "plants", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1826448", "name": "C1826448#ent", "pos": [9, 10]}}
{"token": ["Extracellular", "superoxide", "dismutase", "C1099812#ent", "<e1>", ")", "controls", "the", "availability", "of", "C1420308#ent", "<e2>", ")", ",", "which", "is", "important", "for", "a", "variety", "of", "physiological", "pathways", ",", "including", "the", "primary", "means", "of", "inactivating", "nitric", "oxide", "NO", ")", "."], "h": {"id": "C1099812", "name": "C1099812#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420308", "name": "C1420308#ent", "pos": [10, 11]}}
{"token": ["C0037501#ent", "<e1>", "has", "been", "shown", "to", "have", "therapeutic", "effects", "C0243026#ent", "<e2>", "and", "endotoxin", "shock", "to", "reduce", "liver", "damage", "rats", "intoxicated", "with", "ethanol", "or", "carbon", "tetrachloride"], "h": {"id": "C0037501", "name": "C0037501#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [9, 10]}}
{"token": ["C0178503#ent", "<e1>", "cause", "a", "hyperdynamic", "circulation", "thus", "aggravate", "the", "effects", "of", "C0005122#ent", "<e2>"], "h": {"id": "C0178503", "name": "C0178503#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0005122", "name": "C0005122#ent", "pos": [11, 12]}}
{"token": ["To", "evaluate", "the", "efficacy", "and", "safety", "of", "outpatient", "C0012291#ent", "<e1>", "DHE", ")", "for", "treatment", "of", "C0009088#ent", "<e2>"], "h": {"id": "C0012291", "name": "C0012291#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0009088", "name": "C0009088#ent", "pos": [15, 16]}}
{"token": ["Responsible", "drugs", "were", "mainly", "angiotensin-converting", "enzyme", "inhibitors", "alone", "or", "in", "combination", "with", "C0020261#ent", "<e1>", ",", "followed", "by", "one", "case", "each", "for", "C0717825#ent", "<e2>", "allopurinol", ",", "nimesulide", ",", "acetyl", "salicylic", "acid"], "h": {"id": "C0020261", "name": "C0020261#ent", "pos": [12, 13]}, "relation": "part_of", "t": {"id": "C0717825", "name": "C0717825#ent", "pos": [21, 22]}}
{"token": ["Under", "higher", "salt", "conditions", ",", "which", "inhibited", "the", "binding", "of", "C1528018#ent", "<e1>", ",", "activation", "of", "the", "C0031727#ent", "<e2>", "required", "the", "addition", "of", "Ku", "."], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [10, 11]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [16, 17]}}
{"token": ["Nebulization", "has", "multiple", "clinical", "indications", ",", "such", "as", "asthma", ",", "C0010674#ent", "<e1>", "chronic", "obstructive", "pulmonary", "disease", "Pneumocystis", "carinii", "pneumonia", "acute", "laryngitis", "and", "in", "infants", ",", "C0001311#ent", "<e2>"], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001311", "name": "C0001311#ent", "pos": [25, 26]}}
{"token": ["C3542928#ent", "<e1>", "may", "provide", "novel", "therapeutic", "strategies", "the", "treatment", "of", "C0268790#ent", "<e2>", "be", "a", "potential", "therapeutic", "target", "in", "aberrant", "vessel", "formation", "."], "h": {"id": "C3542928", "name": "C3542928#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [10, 11]}}
{"token": ["In", "contrast", "to", "conditional", "knock-out", "of", "PDK1", "in", "muscle", ",", "the", "knock-in", "mice", "not", "develop", "dilated", "cardiomyopathy", "suggesting", "that", "C1705341#ent", "<e1>", "plays", "a", "key", "role", "in", "protecting", "mice", "from", "C0018801#ent", "<e2>"], "h": {"id": "C1705341", "name": "C1705341#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [29, 30]}}
{"token": ["Mice", "sensitized", "to", "native", "C0041931#ent", "<e1>", "were", "injected", "with", "C0041931#ent", "<e1>", ",", "C2350656#ent", "<e1>", "35", "%", "or", "70", "%", "to", "induce", "tolerance", "."], "h": {"id": "C0041931", "name": "C0041931#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C2350656", "name": "C2350656#ent", "pos": [12, 13]}}
{"token": ["Glycoamidases", "(", "peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine", "amidase", "EC", "3.5.1.52", ";", "also", "known", "as", "peptide", ":", "C0061642#ent", "<e1>", ")", "release", "N-linked", "oligosaccharides", "glycopeptides", "and/or", "glycoproteins", "by", "C0054741#ent", "<e2>", "the", "glycosylated", "beta-amide", "bond", "of", "the", "asparagine", "side", "chain"], "h": {"id": "C0061642", "name": "C0061642#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0054741", "name": "C0054741#ent", "pos": [22, 23]}}
{"token": ["Periventricular", "leukomalacia", "found", "in", "8", "twins", "and", "7", "also", "had", "mild", "ventriculomegaly", "of", "the", "C1332416#ent", "<e1>", "17", "twins", ",", "5", "had", "either", "C0751280#ent", "<e2>", "mild", "ventriculomegaly", "both", "."], "h": {"id": "C1332416", "name": "C1332416#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751280", "name": "C0751280#ent", "pos": [22, 23]}}
{"token": ["The", "difference", "in", "C0003364#ent", "<e1>", "a", "function", "of", "the", "circadian", "dosing-time", "of", "C0076840#ent", "<e2>", "here", "documented", "should", "be", "taken", "into", "account", "when", "prescribing", "this", "loop", "diuretic", "treat", "essential", "hypertensive", "patients", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0076840", "name": "C0076840#ent", "pos": [12, 13]}}
{"token": ["C0362046#ent", "<e1>", "thought", "to", "be", "a", "negative", "factor", "the", "response", "of", "C0529793#ent", "<e2>", "treatment", "in", "dialysis", "patients", "."], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0529793", "name": "C0529793#ent", "pos": [11, 12]}}
{"token": ["The", "patient", "presented", "with", "C0221166#ent", "<e1>", "providing", "a", "wide", "differential", "diagnosis", "ranging", "from", "C3890941#ent", "<e2>", "spinal", "neoplasm"], "h": {"id": "C0221166", "name": "C0221166#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890941", "name": "C3890941#ent", "pos": [13, 14]}}
{"token": ["The", "objective", "of", "our", "study", "was", "to", "assess", "the", "impact", "of", "entacapone", ",", "a", "C0007407#ent", "<e1>", "inhibitor", ",", "on", "plasma", "levels", "homocysteine", ",", "serum", "folate", "and", "C2936883#ent", "<e2>", "levodopa-treated", "PD", "patients", "."], "h": {"id": "C0007407", "name": "C0007407#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2936883", "name": "C2936883#ent", "pos": [26, 27]}}
{"token": ["On", "investigation", "the", "cause", "of", "C0010520#ent", "<e1>", "was", "found", "to", "be", "congenital", "methaemoglobinaemia", "to", "C0268193#ent", "<e2>"], "h": {"id": "C0010520", "name": "C0010520#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0268193", "name": "C0268193#ent", "pos": [14, 15]}}
{"token": ["A", "predictive", "model", "can", "be", "constructed", "with", "three", "LM", "(", "hyalinosis", ",", "tubular", "atrophy", "C0178664#ent", "<e1>", "and", "three", "C1705457#ent", "<e2>", "variables", "(", "subepithelial", ",", "mesangial", "and", "intramembranous", "deposits", ")", "."], "h": {"id": "C0178664", "name": "C0178664#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705457", "name": "C1705457#ent", "pos": [18, 19]}}
{"token": ["C0059032#ent", "<e1>", "analogs", "displayed", "a", "range", "of", "correlation", "coefficients", "r", ")", "with", "C1704939#ent", "<e2>", "(", "ABCB1", ",", "encoding", "multidrug", "resistance", "MDR", ")", "protein", "C1704939#ent", "<e2>", "or", "P-glycoprotein", ")", "."], "h": {"id": "C0059032", "name": "C0059032#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [12, 13]}}
{"token": ["One", "exceptional", "polypeptide", "observed", "in", "C1333213#ent", "<e1>", "was", "present", "neither", "in", "AB1", "nor", "C1416886#ent", "<e2>", "."], "h": {"id": "C1333213", "name": "C1333213#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416886", "name": "C1416886#ent", "pos": [13, 14]}}
{"token": ["We", "evaluated", "whether", "C0014556#ent", "<e1>", "MTE", ")", "and", "neocortical", "temporal", "lobe", "epilepsy", "C1417861#ent", "<e2>", ")", "can", "be", "distinguished", "on", "electroclinical", "grounds", "."], "h": {"id": "C0014556", "name": "C0014556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1417861", "name": "C1417861#ent", "pos": [12, 13]}}
{"token": ["The", "risk", "factors", "pathophysiology", "of", "C0024141#ent", "<e1>", "reviewed", "with", "respect", "to", "the", "biomechanical", "effects", "of", "and", "C0018606#ent", "<e2>", "and", "segmental", "instrumentation", "systems", "on", "the", "spine", "."], "h": {"id": "C0024141", "name": "C0024141#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018606", "name": "C0018606#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "SU5416", "was", "found", "to", "inhibit", "C0033681#ent", "<e1>", "Flt-1", "in", "response", "to", "C3537355#ent", "<e2>", "in", "vitro"], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3537355", "name": "C3537355#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "C1706441#ent", "<e1>", "induced", "tumoricidal", "activity", "was", "enhanced", "by", "adding", "C0175697#ent", "<e2>", "to", "the", "culture", "medium"], "h": {"id": "C1706441", "name": "C1706441#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [12, 13]}}
{"token": ["Recently", "identified", "single", "nucleotide", "polymorphisms", "in", "the", "C1419070#ent", "<e1>", "compromise", "receptor", "function", "that", "some", "genetic", "variations", "predispose", "individuals", "to", "increased", "C0007222#ent", "<e2>"], "h": {"id": "C1419070", "name": "C1419070#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [20, 21]}}
{"token": ["C1366763#ent", "<e1>", "can", "bind", "to", "the", "p50", "subunit", "NF-kappaB", ",", "and", "cotransfection", "of", "C1366763#ent", "<e1>", "with", "the", "p50", "and", "C1453853#ent", "<e1>", "NF-kappaB", "synergistically", "enhances", "transactivation", "of", "the", "NOS2", "promoter", "by", "C1366763#ent", "<e1>", "."], "h": {"id": "C1366763", "name": "C1366763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1453853", "name": "C1453853#ent", "pos": [19, 20]}}
{"token": ["C1337052#ent", "<e1>", "PAK", ")", "2", "is", "a", "small", "C0380931#ent", "<e2>", "various", "cytoskeletal", "functions", "is", "cleaved", "by", "caspase-3", "during", "apoptosis", "."], "h": {"id": "C1337052", "name": "C1337052#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0380931", "name": "C0380931#ent", "pos": [8, 9]}}
{"token": ["Further", ",", "BMP2", "partially", "reverses", "the", "inhibitory", "effect", "of", "C1421245#ent", "<e1>", "and", "Chd", "on", "C1427121#ent", "<e2>", "activity", "."], "h": {"id": "C1421245", "name": "C1421245#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1427121", "name": "C1427121#ent", "pos": [14, 15]}}
{"token": ["CGF", "caused", "a", "transient", "increase", "in", "cytoplasmic", "Ca2", "+", "concentration", ",", "and", "this", "was", "accompanied", "by", "enhancement", "of", "membrane", "protein", "kinase", "C", "activity", "myelin", "basic", "protein", "C0073337#ent", "<e1>", "inositol", "phosphate", ",", "and", "activation", "of", "C0087140#ent", "<e2>", "and", "jun-B", "gene", "."], "h": {"id": "C0073337", "name": "C0073337#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [34, 35]}}
{"token": ["There", "is", "increasing", "evidence", "that", "C1417544#ent", "<e1>", "regulated", "by", "C1420872#ent", "<e2>", "in", "these", "compartments", "via", "the", "regulation", "of", "actin", "attachment", "ATPase", "kinetics", ",", "or", "by", "stabilization", "of", "cytoskeletal", "tracks", "for", "myosin-based", "transport", "."], "h": {"id": "C1417544", "name": "C1417544#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420872", "name": "C1420872#ent", "pos": [9, 10]}}
{"token": ["Most", "of", "these", "hybrid", "drugs", "beta-adrenoceptor", "blockers", "an", "additional", "C0042402#ent", "<e1>", "component", ",", "such", "as", "C0699440#ent", "<e2>", ",", "dilevalol", ",", "carvedilol", "and", "celiprolol", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0699440", "name": "C0699440#ent", "pos": [15, 16]}}
{"token": ["Schistosoma", "japonicum", "paramyosin", "a", "97", "kDa", "C2678065#ent", "<e1>", "is", "a", "recognized", "vaccine", "candidate", "against", "C0036323#ent", "<e2>", "."], "h": {"id": "C2678065", "name": "C2678065#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0036323", "name": "C0036323#ent", "pos": [14, 15]}}
{"token": ["These", "conditions", "include", "the", "long", "QT", "syndrome", "Brugada", "syndrome", "C4053736#ent", "<e1>", "tachycardia", "and", "the", "C1865020#ent", "<e2>"], "h": {"id": "C4053736", "name": "C4053736#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1865020", "name": "C1865020#ent", "pos": [14, 15]}}
{"token": ["The", "smallest", "deletion", "detected", "in", "a", "C1956097#ent", "<e1>", "patient", "thus", "far", "includes", "two", "candidate", "genes", ",", "C1421505#ent", "<e2>", "and", "WHSC2", "."], "h": {"id": "C1956097", "name": "C1956097#ent", "pos": [6, 7]}, "relation": "disease_has_associated_gene", "t": {"id": "C1421505", "name": "C1421505#ent", "pos": [16, 17]}}
{"token": ["As", "the", "mutation", "of", "the", "gene", "coding", "nephrin", "induces", "C3501848#ent", "<e1>", "Finnish", "type", "which", "is", "a", "prototype", "of", "C0027726#ent", "<e2>", "it", "has", "been", "suggested", "that", "nephrin", "also", "plays", "a", "role", "in", "acquired", "proteinuric", "kidney", "disease"], "h": {"id": "C3501848", "name": "C3501848#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [18, 19]}}
{"token": ["In", "fat", "body", "tissue", "activities", "of", "C1417092#ent", "<e1>", "3-hydroxyacyl-CoA", "dehydrogenase", "increased", "during", "food", "deprivation", "activities", "of", "glyceraldehyde-3-phosphate", "dehydrogenase", "malate", "dehydrogenase", "C0001899#ent", "<e2>", "unchanged", "."], "h": {"id": "C1417092", "name": "C1417092#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001899", "name": "C0001899#ent", "pos": [20, 21]}}
{"token": ["The", "acute", "attack", "C0018099#ent", "<e1>", "responds", "to", "any", "nonsteroidal", "anti-inflammatory", "drug", "and", "antihyperuricemic", "therapy", "with", "C0002144#ent", "<e2>", ",", "probenecid", "or", "sulfinpyrazone", "is", "effective", "in", "lowering", "uric", "acid", "preventing", "further", "attacks", "."], "h": {"id": "C0018099", "name": "C0018099#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0002144", "name": "C0002144#ent", "pos": [15, 16]}}
{"token": ["We", "demonstrate", "here", "that", "PKA", "'s", "activation", "of", "C1426113#ent", "<e1>", "was", "mediated", "by", "the", "C1426113#ent", "<e1>", "guanine", "nucleotide", "exchange", "factor", "C3G", "the", "adaptor", "Crk-L", "the", "scaffold", "protein", "Cbl", ",", "and", "the", "C1332794#ent", "<e1>"], "h": {"id": "C1426113", "name": "C1426113#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332794", "name": "C1332794#ent", "pos": [31, 32]}}
{"token": ["C1419756#ent", "<e1>", "reveal", "a", "single", ",", "high", "affinity", "C1839259#ent", "<e2>", ",", "5.8", "nM", ")", ",", "saturable", ",", "low", "abundance", "binding", "species", "carboxy-terminal", "rhMIS", "."], "h": {"id": "C1419756", "name": "C1419756#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [8, 9]}}
{"token": ["Clinically", ",", "it", "can", "be", "misdiagnosed", "as", "retropharyngeal", "abscess", "traumatic", "injury", "infectious", "spondylitis", "C0002949#ent", "<e1>", "or", "even", "C0025289#ent", "<e2>", "."], "h": {"id": "C0002949", "name": "C0002949#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "C0007971#ent", "<e1>", "treated", "with", "photodynamic", "therapy", "PDT", ")", "using", "C3815531#ent", "<e2>", "ALA", ")", ",", "with", "satisfactory", "outcome", "in", "both", "clinical", "and", "pathological", "aspects"], "h": {"id": "C0007971", "name": "C0007971#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3815531", "name": "C3815531#ent", "pos": [14, 15]}}
{"token": ["However", ",", "only", "C0764610#ent", "<e1>", ",", "not", "specific", "caspase", "inhibitors", "Z-DEVD", "for", "caspase", "3", "Z-YVAD", "for", "C0534519#ent", "<e2>", ",", "was", "effective", "in", "the", "suppression", "of", "cell", "spreading"], "h": {"id": "C0764610", "name": "C0764610#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [16, 17]}}
{"token": ["Two", "NAD-dependent", "enzymatic", "activities", ",", "an", "C1412333#ent", "<e1>", "CoA-acetylating", ")", "(", "EC", "1.2.1.10", ")", "and", "an", "alcohol", "dehydrogenase", "C0001942#ent", "<e2>", "were", "detected", "."], "h": {"id": "C1412333", "name": "C1412333#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "the", "gene", "MCOLN1", "for", "the", "TRP", "(", "C1421171#ent", "<e1>", "family", "ion", "channel", "lead", "to", "the", "lipid", "storage", "disorder", "mucolipidosis", "type", "IV", "C1421947#ent", "<e2>", ")", "."], "h": {"id": "C1421171", "name": "C1421171#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1421947", "name": "C1421947#ent", "pos": [23, 24]}}
{"token": ["Treatment", "of", "T47D", "cells", "with", "the", "C0014941#ent", "<e1>", "R5020", "induced", "a", "time-", "and", "dose-dependent", "increase", "in", "C1334133#ent", "<e2>", "content", "as", "measured", "by", "both", "ligand-binding", "studies", "radioimmunoassay", "."], "h": {"id": "C0014941", "name": "C0014941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334133", "name": "C1334133#ent", "pos": [16, 17]}}
{"token": ["C0035242#ent", "<e1>", "including", "asthma", "and", "chronic", "obstructive", "pulmonary", "disease", "are", "among", "the", "most", "significant", "C0029896#ent", "<e2>", "in", "terms", "of", "their", "disabling", "effects", "healthcare", "burden"], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [14, 15]}}
{"token": ["Gel", "shift", "reporter", "gene", "ChIP", "assays", "identified", "in", "total", "10", "functional", "C1706113#ent", "<e1>", "in", "the", "genes", "IGFBP1", ",", "IGFBP3", "and", "C1334096#ent", "<e2>", "."], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334096", "name": "C1334096#ent", "pos": [20, 21]}}
{"token": ["C1257763#ent", "<e1>", "is", "associated", "with", "developmental", "defects", "the", "enamel", "which", "increase", "susceptibility", "to", "C0011334#ent", "<e2>"], "h": {"id": "C1257763", "name": "C1257763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0011334", "name": "C0011334#ent", "pos": [13, 14]}}
{"token": ["A", "21-year-old", "white", "woman", "presented", "with", "virilization", ",", "hirsutism", ",", "and", "C0001144#ent", "<e1>", "of", "1.5", "years", "'", "C0720099#ent", "<e2>", "."], "h": {"id": "C0001144", "name": "C0001144#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0720099", "name": "C0720099#ent", "pos": [17, 18]}}
{"token": ["C0037549#ent", "<e1>", "increased", "fibrinolytic", "activities", "blood", "and", "of", "purified", "C0064833#ent", "<e2>", "in", "vitro", "whereas", "aspirin", "had", "little", "effect", "."], "h": {"id": "C0037549", "name": "C0037549#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [9, 10]}}
{"token": ["Western", "analysis", "confocal", "immunofluorescent", "microscopy", "a", "marked", "increase", "in", "hepatic", "expression", "of", "multidrug", "resistance-associated", "protein", "3", "Mrp3", ")", "in", "both", "groups", "pretreated", "with", "C0000970#ent", "<e1>", ",", "relative", "to", "expression", "of", "C2828741#ent", "<e2>", "."], "h": {"id": "C0000970", "name": "C0000970#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C2828741", "name": "C2828741#ent", "pos": [30, 31]}}
{"token": ["As", "shown", "by", "gelatin", "zymography", "HL-60", "cells", "C0907533#ent", "<e1>", "released", "significant", "amounts", "of", "C0907856#ent", "<e2>", "(", "92", "kDa", ")", "and", "moderate", "amounts", "proMMP-2", "(", "72", "kDa", ")", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0907856", "name": "C0907856#ent", "pos": [13, 14]}}
{"token": ["The", "decrease", "in", "coronary", "blood", "flow", "velocity", "abolished", "by", "stellate", "ganglionectomy", "C1332027#ent", "<e1>", "blockade", "without", "C2712370#ent", "<e2>", "pressor", "or", "femoral", "responses"], "h": {"id": "C1332027", "name": "C1332027#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [15, 16]}}
{"token": ["There", "is", "no", "evidence", "for", "cross-reactivity", "with", "drugs", "that", "have", "different", "underlying", "structures", "but", "share", "a", "C0038760#ent", "<e1>", "such", "as", "C0000981#ent", "<e2>", ",", "furosemide", ",", "glipizide", ",", "or", "hydrochlorthiazide", "."], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [16, 17]}, "relation": "chemical_structure_of", "t": {"id": "C0000981", "name": "C0000981#ent", "pos": [20, 21]}}
{"token": ["Reports", "of", "hyperostosis", "in", "patients", "receiving", "prostaglandin", "E", "maintain", "a", "patent", "ductus", "arteriosus", "that", "C0356622#ent", "<e1>", "may", "play", "a", "role", "in", "the", "etiology", "of", "C0020497#ent", "<e2>"], "h": {"id": "C0356622", "name": "C0356622#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020497", "name": "C0020497#ent", "pos": [24, 25]}}
{"token": ["The", "survival", "signal", "pathway", "transduced", "by", "C0525678#ent", "<e1>", "was", "essentially", "mediated", "by", "inhibition", "of", "C1705066#ent", "<e2>", "PI3K/Akt", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705066", "name": "C1705066#ent", "pos": [14, 15]}}
{"token": ["The", "C0024776#ent", "<e1>", "alpha-ketoisocaproate", "and", "alpha-ketoisovalerate", "were", "also", "potent", "inhibitors", "of", "hepatocyte", "C1420102#ent", "<e2>", "with", "K0.5", "values", "of", "270", "and", "340", "microM", ",", "respectively", "."], "h": {"id": "C0024776", "name": "C0024776#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420102", "name": "C1420102#ent", "pos": [12, 13]}}
{"token": ["One", "of", "the", "GBP", "pathway", "components", "is", "phospholipase", "C", "whose", "activation", "is", "essential", "for", "the", "activation", "of", "C3849574#ent", "<e1>", "and", "elevation", "of", "expression", "of", "both", "C1333402#ent", "<e2>"], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [17, 18]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [25, 26]}}
{"token": ["Here", ",", "we", "report", "the", "identification", "of", "a", "third", "gene", "C1413160#ent", "<e1>", "HP1alpha", ",", "also", "known", "as", "C2347769#ent", "<e2>", ")", ",", "which", "is", "located", "downstream", "of", "HnRNP", "A1", "and", "p45", "NFE2"], "h": {"id": "C1413160", "name": "C1413160#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2347769", "name": "C2347769#ent", "pos": [17, 18]}}
{"token": ["Two", "newborn", "infants", "with", "C0476273#ent", "<e1>", "all", "the", "clinical", "and", "radiologic", "stigmata", "the", "C1861922#ent", "<e2>", "campomelia", "itself", "."], "h": {"id": "C0476273", "name": "C0476273#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C1861922", "name": "C1861922#ent", "pos": [13, 14]}}
{"token": ["Two", "newborn", "infants", "with", "C0476273#ent", "<e1>", "all", "the", "clinical", "and", "radiologic", "stigmata", "the", "campomelic", "dysplasia", "C1861922#ent", "<e2>", "itself", "."], "h": {"id": "C0476273", "name": "C0476273#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C1861922", "name": "C1861922#ent", "pos": [15, 16]}}
{"token": ["Therefore", ",", "C3495555#ent", "<e1>", "may", "be", "applied", "to", "human", "being", "as", "a", "C1254351#ent", "<e2>", "against", "aging", "."], "h": {"id": "C3495555", "name": "C3495555#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [12, 13]}}
{"token": ["Strong", "chemical", "evidence", "the", "existence", "of", "a", "covalent", "binary", "complex", "between", "5-fluorodeoxyuridylate", "and", "C1366824#ent", "<e1>", "provided", "by", "the", "isolation", "of", "the", "complex", "by", "C0600203#ent", "<e2>", "precipitation", "."], "h": {"id": "C1366824", "name": "C1366824#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0600203", "name": "C0600203#ent", "pos": [23, 24]}}
{"token": ["The", "relapse", "rates", "lowest", "in", "patients", "with", "C0270851#ent", "<e1>", "childhood", "and", "C0014544#ent", "<e2>", "with", "absence", "seizures", "only", "and", "those", "with", "a", "short", "duration", "of", "epilepsy", "."], "h": {"id": "C0270851", "name": "C0270851#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [11, 12]}}
{"token": ["These", "perineuronal", "C1423506#ent", "<e1>", "of", "proteoglycans", "are", "digested", "by", "chondroitinase", "ABC", "C0020197#ent", "<e2>", ",", "or", "collagenase", ",", "but", "not", "by", "endo-alpha-N-acetylgalactosaminidase", ",", "which", "is", "reactive", "to", "the", "nerve", "cell", "glycoproteins", "."], "h": {"id": "C1423506", "name": "C1423506#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020197", "name": "C0020197#ent", "pos": [11, 12]}}
{"token": ["Reduced", "or", "absent", "C0029454#ent", "<e1>", "distinguish", "these", "patients", "from", "those", "with", "C0878544#ent", "<e2>", "normal", "septa", "or", "dilated", "LV", "'s", "due", "to", "volume", "overload"], "h": {"id": "C0029454", "name": "C0029454#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0878544", "name": "C0878544#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "we", "demonstrate", "that", "stage-specific", "C2986464#ent", "<e1>", "mediated", "by", "C1334882#ent", "<e2>", ",", "regulates", "chondrocyte", "viability", "during", "cartilage", "maturation", "."], "h": {"id": "C2986464", "name": "C2986464#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334882", "name": "C1334882#ent", "pos": [10, 11]}}
{"token": ["We", "report", "that", "stable", "overexpression", "of", "C1883559#ent", "<e1>", "PS1", "led", "to", "a", "decrease", "in", "C1527860#ent", "<e2>", "CDK", "4", "activity", "and", "retinoblastoma", "tumor", "suppressor", "protein", "pRb", ")", "phosphorylation", "that", "correlated", "with", "decreased", "levels", "of", "beta-catenin", "and", "cyclin", "D1"], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1527860", "name": "C1527860#ent", "pos": [14, 15]}}
{"token": ["In", "C0062941#ent", "<e1>", ",", "the", "rate", "of", "rise", "in", "C1421114#ent", "<e2>", "was", "significantly", "higher", "than", "in", "CD", "."], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421114", "name": "C1421114#ent", "pos": [9, 10]}}
{"token": ["Previous", "workers", "have", "reported", "that", "ethyl", "methylene", "blue", "C0014964#ent", "<e1>", ")", "diminishes", "cyanide-induced", "increases", "in", "blood", "lactate", "C1564717#ent", "<e2>", ")", ";", "the", "present", "study", "investigates", "the", "mechanism", "underlying", "this", "interaction", "."], "h": {"id": "C0014964", "name": "C0014964#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1564717", "name": "C1564717#ent", "pos": [17, 18]}}
{"token": ["It", "is", "well", "documented", "that", "nitric", "oxide", "NO", ")", "stimulates", "C1706334#ent", "<e1>", ",", "LH", "and", "C3539616#ent", "<e2>", "release", "."], "h": {"id": "C1706334", "name": "C1706334#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3539616", "name": "C3539616#ent", "pos": [15, 16]}}
{"token": ["C0282625#ent", "<e1>", "whose", "involvement", "in", "cell-ECM", "signaling", "and", "C1419019#ent", "<e2>", "phosphorylation", "in", "B", "lymphocytes", "been", "well", "established", ",", "were", "found", "not", "to", "be", "responsible", "for", "C1419019#ent", "<e2>", "phosphorylation", "in", "epithelial", "cells"], "h": {"id": "C0282625", "name": "C0282625#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1419019", "name": "C1419019#ent", "pos": [8, 9]}}
{"token": ["Histone", "deacetylase", "HDAC", ")", "inhibitors", ",", "but", "not", "C0012873#ent", "<e1>", "upregulated", "maspin", ",", "and", "C1334032#ent", "<e2>", "inhibited", "the", "transactivation", "of", "maspin", "promoter", "."], "h": {"id": "C0012873", "name": "C0012873#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334032", "name": "C1334032#ent", "pos": [14, 15]}}
{"token": ["C0298998#ent", "<e1>", "is", "used", "clinically", "to", "locate", "tumors", "overexpressing", "primarily", "somatostatin", "receptor", "type", "2", "C1335867#ent", "<e2>", ")", "."], "h": {"id": "C0298998", "name": "C0298998#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335867", "name": "C1335867#ent", "pos": [14, 15]}}
{"token": ["In", "doses", "of", "3", "-", "10", "mg/kg", ",", "the", "serotonin", "receptor", "agonist", "C0066633#ent", "<e1>", "caused", "a", "dose-dependent", "blockade", "of", "the", "response", "of", "C0026818#ent", "<e2>", "."], "h": {"id": "C0066633", "name": "C0066633#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [22, 23]}}
{"token": ["C0019357#ent", "<e1>", "HSK", ")", "is", "an", "C0029877#ent", "<e2>", "induced", "by", "HSV-1", "infection", "and", "characterized", "by", "T", "cell-dependent", "destruction", "of", "corneal", "tissues"], "h": {"id": "C0019357", "name": "C0019357#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029877", "name": "C0029877#ent", "pos": [6, 7]}}
{"token": ["The", "relaxation", "of", "supercoiled", "pBR322", "DNA", "by", "C1458146#ent", "<e1>", "inhibited", "by", "these", "metabolites", "as", "potently", "as", "by", "C0594375#ent", "<e2>", "."], "h": {"id": "C1458146", "name": "C1458146#ent", "pos": [7, 8]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [17, 18]}}
{"token": ["Halothane", "and", "isoflurane", "either", "significantly", "(", "P", "less", "than", "0.05", ")", "decreased", "or", "eliminated", "BS", "during", "steady-state", "decreases", "in", "C1456795#ent", "<e1>", ",", "with", "no", "significant", "detected", "between", "C0017302#ent", "<e2>"], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0017302", "name": "C0017302#ent", "pos": [27, 28]}}
{"token": ["Since", "low", "dose", "IL-1", "beta", "diabetes-prone", "rats", "from", "IDDM", ",", "we", "conclude", "that", "C1522428#ent", "<e1>", "beta", "is", "a", "potent", "modulator", "of", "autoimmune", "diabetes", "thyroid", "disease", "C1516876#ent", "<e2>", "susceptible", "rats", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [25, 26]}}
{"token": ["When", "the", "epidermis", "was", "separated", "from", "dermis", "before", "rather", "than", "after", "culture", "(", "using", "CaCl2", ",", "dispase", ",", "C0960371#ent", "<e1>", "or", "suction", ")", "the", "labelled", "C3536869#ent", "<e2>", "peak", "was", "never", "observed", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C3536869", "name": "C3536869#ent", "pos": [25, 26]}}
{"token": ["The", "objective", "of", "this", "study", "was", "to", "delineate", "whether", "the", "presence", "of", "the", "risk", "factors", "C3898144#ent", "<e1>", "MD", ")", "contribute", "to", "the", "prognostic", "outcome", "patients", "with", "C1148477#ent", "<e2>", "ISD", ")", "."], "h": {"id": "C3898144", "name": "C3898144#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1148477", "name": "C1148477#ent", "pos": [26, 27]}}
{"token": ["The", "data", "indicate", "that", "C0077857#ent", "<e1>", "is", "a", "potent", "C0042397#ent", "<e2>"], "h": {"id": "C0077857", "name": "C0077857#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [9, 10]}}
{"token": ["Indeed", "C1692886#ent", "<e1>", "other", "possible", "cause", "of", "C0003864#ent", "<e2>", "were", "ruled", "out", "."], "h": {"id": "C1692886", "name": "C1692886#ent", "pos": [1, 2]}, "relation": "has_nichd_parent", "t": {"id": "C0003864", "name": "C0003864#ent", "pos": [7, 8]}}
{"token": ["Post-HST1", "neuralgia", "may", "simulate", "postherpetic", "neuralgia", "clinically", ",", "and", "C0030193#ent", "<e1>", "respond", "to", "C0002600#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [13, 14]}}
{"token": ["The", "ICR-derived", "glomerulonephritis", "ICGN", ")", "mouse", "is", "a", "novel", "inbred", "mouse", "strain", "with", "a", "C0027706#ent", "<e1>", "considered", "to", "be", "a", "good", "model", "of", "human", "C3496337#ent", "<e2>", "develops", "proteinuria", ",", "hypoproteinemia", "and", "anemia", "."], "h": {"id": "C0027706", "name": "C0027706#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3496337", "name": "C3496337#ent", "pos": [24, 25]}}
{"token": ["In", "rabbit", ",", "after", "short-time", "rapid", "atrial", "pacing", "C0079423#ent", "<e1>", ")", ",", "atrial", "ion", "currents", "reduced", "similarly", "as", "in", "human", "chronic", "atrial", "fibrillation", "C4049859#ent", "<e2>", ")", "."], "h": {"id": "C0079423", "name": "C0079423#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4049859", "name": "C4049859#ent", "pos": [23, 24]}}
{"token": ["We", "also", "present", "evidence", "for", "the", "existence", "of", "two", "gene", "products", "namely", ",", "C2700041#ent", "<e1>", "and", "CfxB", ",", "which", "are", "encoded", "by", "C1417679#ent", "<e2>", "immediately", "upstream", "of", "and", "rbcR", ",", "respectively", "."], "h": {"id": "C2700041", "name": "C2700041#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [22, 23]}}
{"token": ["This", "subset", "included", "poly", "(ADP-ribose)", "polymerase", "the", "70-kD", "protein", "the", "U1", "small", "nuclear", "ribonucleoprotein", "particle", "lamin", "B", "the", "nuclear", "mitotic", "apparatus", "protein", "NuMA", ",", "C0949775#ent", "<e1>", "II", ",", "and", "the", "C0035681#ent", "<e2>", "upstream", "binding", "factor", "UBF", "."], "h": {"id": "C0949775", "name": "C0949775#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [30, 31]}}
{"token": ["In", "both", "species", ",", "the", "corpora", "allata", "CA", ")", "of", "adult", "females", "released", "fmol", "quantities", "of", "C0268060#ent", "<e1>", ",", "with", "JH", "II", "the", "major", "C1334043#ent", "<e2>", "produced", "."], "h": {"id": "C0268060", "name": "C0268060#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [24, 25]}}
{"token": ["The", "C1517495#ent", "<e1>", "functional", "organization", "of", "a", "Bacteroides", "conjugative", "transposon", "(", "C0917591#ent", "<e2>", ")", ",", "CTn341", ",", "were", "determined", "."], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0917591", "name": "C0917591#ent", "pos": [11, 12]}}
{"token": ["Studies", "of", "recent", "years", "have", "revealed", "that", "C1309084#ent", "<e1>", "participates", "in", "HIV", "and", "C0019196#ent", "<e2>", "and", "in", "hepatocellular", "carcinoma", "a", "complication", "of", "hepatitis", "B", "hepatitis", "C", "infections"], "h": {"id": "C1309084", "name": "C1309084#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0019196", "name": "C0019196#ent", "pos": [13, 14]}}
{"token": ["We", "found", "that", "in", "vivo", "estrogen", "treatment", "primes", "splenocytes", "for", "early", "upregulation", "of", "C1420610#ent", "<e1>", "upon", "activation", "by", "C0002763#ent", "<e2>", "Concanavalin-A", "(", "Con-A", ")", "or", "anti-CD3", "antibodies"], "h": {"id": "C1420610", "name": "C1420610#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [18, 19]}}
{"token": ["C0019045#ent", "<e1>", "has", "a", "milder", "course", "than", "C0002895#ent", "<e2>"], "h": {"id": "C0019045", "name": "C0019045#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [7, 8]}}
{"token": ["This", "increased", "trafficking", "of", "C1412493#ent", "<e1>", "was", "suppressed", "by", "C0031671#ent", "<e2>", "protein", "kinase", "C", "PKC", ")", "inhibitors", "and", "a", "phorbol", "ester", "accelerated", "the", "trafficking", "of", "C1412493#ent", "<e1>", "to", "the", "membrane", "fraction"], "h": {"id": "C1412493", "name": "C1412493#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [9, 10]}}
{"token": ["When", "tested", "in", "a", "clinically", "predictive", "rat", "model", "of", "acute", "ischemic", "stroke", "this", "C3555655#ent", "<e1>", "reduced", "brain", "infarction", "indicating", "that", "it", "is", "C0242912#ent", "<e2>", "after", "permanent", "focal", "cerebral", "ischemia"], "h": {"id": "C3555655", "name": "C3555655#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0242912", "name": "C0242912#ent", "pos": [22, 23]}}
{"token": ["In", "this", "study", ",", "we", "characterized", "the", "lipid", "composition", "C1832370#ent", "<e1>", "from", "a", "cell", "model", "the", "sphingolipid", "storage", "disorder", "C1961835#ent", "<e2>", "in", "which", "the", "catabolism", "of", "the", "sphingolipid", "glucosylceramide", "GC", ")", "is", "impaired", "."], "h": {"id": "C1832370", "name": "C1832370#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [19, 20]}}
{"token": ["C1826396#ent", "<e1>", "heterogeneity", "has", "been", "demonstrated", "using", "a", "monoclonal", "antibody", "C1412930#ent", "<e2>", ")", "specific", "for", "the", "150,000", "molecular", "weight", "neurofilament", "subunit"], "h": {"id": "C1826396", "name": "C1826396#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412930", "name": "C1412930#ent", "pos": [10, 11]}}
{"token": ["Monocyte", "chemoattractant", "protein", ",", "macrophage", "inflammatory", "protein", "(MIP)-1alpha", "MIP-1beta", "and", "C1522712#ent", "<e1>", "measured", "in", "30", "patients", "with", "culture-proven", "C0243026#ent", "<e2>", "during", "a", "3-day", "follow-up", "and", "in", "11", "healthy", "humans", "after", "intravenous", "injection", "endotoxin", "(", "4", "ng/kg", ")", "."], "h": {"id": "C1522712", "name": "C1522712#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [18, 19]}}
{"token": ["Pre-exposure", "of", "myocytes", "to", "the", "cytoskeletal", "disrupting", "agents", "C0028247#ent", "<e1>", "(", "microtubule", "specific", ")", "or", "cytochalasin", "D", "C1334752#ent", "<e2>", "specific", ")", "prevented", "the", "effects", "of", "increases", "in", "P(o", ")", "of", "LTCCs", "in", "excised", "membrane", "patches"], "h": {"id": "C0028247", "name": "C0028247#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1334752", "name": "C1334752#ent", "pos": [17, 18]}}
{"token": ["the", "pluronic", "polyol", "L121", "and", "C0376944#ent", "<e1>", "DDA", ")", "instead", "of", "C1414134#ent", "<e2>", "."], "h": {"id": "C0376944", "name": "C0376944#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414134", "name": "C1414134#ent", "pos": [11, 12]}}
{"token": ["In", "this", "study", "we", "report", "the", "identification", ",", "cloning", ",", "and", "characterization", "of", "the", "mouse", "C1412296#ent", "<e1>", "its", "function", "as", "an", "C1443775#ent", "<e2>"], "h": {"id": "C1412296", "name": "C1412296#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1443775", "name": "C1443775#ent", "pos": [21, 22]}}
{"token": ["To", "determine", "the", "relative", "susceptibility", "C0036330#ent", "<e1>", "treatment", "with", "the", "C0029994#ent", "<e2>", "(", "OXA", ")", "and", "praziquantel", "(", "PZQ", ")", "."], "h": {"id": "C0036330", "name": "C0036330#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0029994", "name": "C0029994#ent", "pos": [10, 11]}}
{"token": ["C3537294#ent", "<e1>", "furthermore", "induces", "indirect", "activation", "of", "C0751984#ent", "<e2>", "Rac", ")", "in", "intact", "cells", "."], "h": {"id": "C3537294", "name": "C3537294#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [7, 8]}}
{"token": ["C0543495#ent", "<e1>", "significantly", "reduced", "the", "acute", "bronchoconstrictor", "effects", "of", "C0235480#ent", "<e2>", ",", "but", "did", "not", "affect", "the", "increase", "in", "lung", "epithelial", "permeability", ",", "which", "was", "58", "+", "/-", "10", "%", "."], "h": {"id": "C0543495", "name": "C0543495#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [9, 10]}}
{"token": ["There", "was", "no", "difference", "in", "A(1)", "A(3)", "C1419386#ent", "<e1>", "between", "WT", "and", "C4284124#ent", "<e2>", "animals", "."], "h": {"id": "C1419386", "name": "C1419386#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4284124", "name": "C4284124#ent", "pos": [12, 13]}}
{"token": ["A", "22-year-old", "multigravid", "female", "presented", "to", "the", "emergency", "department", "a", "C0030193#ent", "<e1>", "high", "fever", "and", "severe", "C0032238#ent", "<e2>", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032238", "name": "C0032238#ent", "pos": [16, 17]}}
{"token": ["In", "the", "cortex", ",", "C0085437#ent", "<e1>", "to", "a", "significant", "upregulation", "of", "mRNA", "encoding", "C1706044#ent", "<e2>", "."], "h": {"id": "C0085437", "name": "C0085437#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [13, 14]}}
{"token": ["In", "particular", ",", "plasma", "membrane-located", "responses", "such", "as", "(Na/K)-ATPase", "and", "C0058980#ent", "<e1>", "aminoacid", "transport", "studied", "together", "with", "cytoplasmic", "responses", "as", "the", "C0041487#ent", "<e2>"], "h": {"id": "C0058980", "name": "C0058980#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041487", "name": "C0041487#ent", "pos": [21, 22]}}
{"token": ["Inhibitors", "of", "both", "NF-kappaB", "and", "C1333571#ent", "<e1>", "prevented", "HG-", "and", "ET-induced", "C1706331#ent", "<e2>", "production", "."], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [11, 12]}}
{"token": ["treatment", "with", "blocking", "doses", "of", "the", "putative", "5-HT", "receptor", "antagonists", "C0290799#ent", "<e1>", "5-HT1A", ")", ",", "cyanopindolol", "(", "5-HT(1A/1B", ")", ")", "or", "C0291459#ent", "<e2>", "5-HT(1B/1D", ")", ")", "."], "h": {"id": "C0290799", "name": "C0290799#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0291459", "name": "C0291459#ent", "pos": [21, 22]}}
{"token": ["Glyceraldehyde-3-phosphate", "oxidation", "catalysed", "by", "glyceraldehyde-3-phosphate", "dehydrogenase", "the", "presence", "of", "C1334289#ent", "<e1>", "(", "which", "ensures", "rapid", "equilibration", "of", "the", "C3887669#ent", "<e2>", ")", "follows", "single", "first-order", "kinetics", "."], "h": {"id": "C1334289", "name": "C1334289#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3887669", "name": "C3887669#ent", "pos": [18, 19]}}
{"token": ["C0006931#ent", "<e1>", "also", "markedly", "induced", "the", "phosphorylation", "of", "C0812228#ent", "<e2>", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [8, 9]}}
{"token": ["Both", "MAP2", "and", "C1418556#ent", "<e1>", "showed", "differential", "expression", "patterns", "of", "their", "component", "C0030956#ent", "<e2>", "."], "h": {"id": "C1418556", "name": "C1418556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}}
{"token": ["During", "4", "weeks", "the", "rapidly", "progressive", "hearing", "loss", "accompanied", "by", "tinnitus", "and", "C0042571#ent", "<e1>", "and", "an", "C0155088#ent", "<e2>"], "h": {"id": "C0042571", "name": "C0042571#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0155088", "name": "C0155088#ent", "pos": [16, 17]}}
{"token": ["Two", "related", "segmental", "progerias", "C0009207#ent", "<e1>", "CS", ")", "and", "C3495483#ent", "<e2>", "(", "TTD", ")", ",", "do", "n't", "fit", "this", "pattern", "."], "h": {"id": "C0009207", "name": "C0009207#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3495483", "name": "C3495483#ent", "pos": [9, 10]}}
{"token": ["This", "meeting", "focused", "on", "three", "disorders", "of", "DNA", "repair", "transcription", ":", "C0009207#ent", "<e1>", "CS", ")", ",", "xeroderma", "pigmentosum", "XP", ")", "and", "C3495483#ent", "<e2>", "(", "TTD", ")", "."], "h": {"id": "C0009207", "name": "C0009207#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3495483", "name": "C3495483#ent", "pos": [21, 22]}}
{"token": ["The", "highest", "absolute", "levels", "of", "C3714750#ent", "<e1>", "transcripts", "were", "found", "following", "rifampin", "treatment", "in", "C0669372#ent", "<e2>", "and", "intestines", "from", "carriers", "of", "CYP3A5*1", "alleles"], "h": {"id": "C3714750", "name": "C3714750#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [14, 15]}}
{"token": ["In", "vitro", "binding", "of", "64Cu", "to", "serum", "proteins", "were", "transferred", "to", "C0600190#ent", "<e1>", "by", "Western", "blotting", "techniques", "showed", "that", "C1412332#ent", "<e2>", "is", "essentially", "the", "only", "protein", "that", "binds", "appreciable", "amounts", "of", "copper", "."], "h": {"id": "C0600190", "name": "C0600190#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", "to", "TNF", "and", "IL-1", ",", "C2697656#ent", "<e1>", "did", "not", "cause", "sphingomyelin", "hydrolysis", "and", "thus", "stimulates", "C1442514#ent", "<e2>", "generating", "ceramide", "."], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1442514", "name": "C1442514#ent", "pos": [17, 18]}}
{"token": ["These", "results", "provide", "evidence", "that", "normal", "human", "skin", "keratinocytes", "fibroblasts", "express", "genes", "encoding", "laminin", "A", "C1706319#ent", "<e1>", ",", "B2", ",", "alpha", "1(IV", ")", ",", "and", "C1539312#ent", "<e2>", "at", "a", "steady-state", "level", "."], "h": {"id": "C1706319", "name": "C1706319#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [25, 26]}}
{"token": ["These", "W6", "C3540790#ent", "<e1>", "showed", "strong", "C1332127#ent", "<e2>", "capable", "of", "inducing", "edema", "in", "rat", "paws", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332127", "name": "C1332127#ent", "pos": [6, 7]}}
{"token": ["More", "specifically", ",", "there", "will", "be", "an", "examination", "of", "the", "effect", "of", "smoking", "on", "the", "outcome", "of", "a", "carotid", "endarterectomy", "C0038525#ent", "<e1>", "the", "progression", "of", "C0004153#ent", "<e2>", "."], "h": {"id": "C0038525", "name": "C0038525#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [25, 26]}}
{"token": ["The", "study", "revealed", "the", "efficacy", "of", "high", "dosages", "of", "nootropil", "in", "combination", "with", "basic", "C0003299#ent", "<e1>", "the", "treatment", "of", "C0085543#ent", "<e2>"], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [19, 20]}}
{"token": ["Interest", "has", "focused", "on", "C3494348#ent", "<e1>", "of", "voltage-dependent", "Na+", "channels", "potential", "neuroprotective", "agents", "they", "prevent", "neuronal", "death", "various", "experimental", "models", "C0007787#ent", "<e2>", "act", "cytoprotectively", "in", "models", "of", "white", "matter", "damage", "."], "h": {"id": "C3494348", "name": "C3494348#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [20, 21]}}
{"token": ["Three", "patients", "had", "a", "C0000833#ent", "<e1>", "one", "a", "tuberculous", "abscess", "the", "other", "had", "a", "C0343401#ent", "<e2>"], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0343401", "name": "C0343401#ent", "pos": [14, 15]}}
{"token": ["C0055895#ent", "<e1>", "was", "faster", "in", "restoring", "barrier", "function", "C0065767#ent", "<e2>", "."], "h": {"id": "C0055895", "name": "C0055895#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0065767", "name": "C0065767#ent", "pos": [8, 9]}}
{"token": ["DNA-PK", "is", "composed", "of", "a", "large", "catalytic", "subunit", "C1528018#ent", "<e1>", ")", "and", "a", "heterodimer", "of", "Ku70", "and", "C1337034#ent", "<e2>", "that", "assemble", "on", "the", "ends", "of", "double-stranded", "DNA", "form", "an", "active", "serine/threonine", "protein", "kinase", "complex"], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1337034", "name": "C1337034#ent", "pos": [17, 18]}}
{"token": ["Factor", "H", "a", "C0086903#ent", "<e1>", "the", "alternative", "pathway", "of", "complement", "activation", "of", "20", "tandem", "repeating", "units", "60", "C3539946#ent", "<e2>", "."], "h": {"id": "C0086903", "name": "C0086903#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [17, 18]}}
{"token": ["On", "the", "other", "hand", ",", "the", "omega-amino", "acids", "with", "long-chain", "structure", "(", "C0619807#ent", "<e1>", "6-guanidinohexanesulfonic", "acid", "acted", "as", "excitants", ",", "induced", "C0036572#ent", "<e2>", "and", "developed", "typical", "biphasic", "spikes", "high", "amplitudes", "in", "the", "EEG", "."], "h": {"id": "C0619807", "name": "C0619807#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "it", "was", "proved", "that", "the", "peptides", "in", "soybean", "protein", "hydrolysate", "C2674218#ent", "<e1>", ")", "made", "by", "certain", "C0030940#ent", "<e2>", "have", "a", "hypocholesterolemic", "effect"], "h": {"id": "C2674218", "name": "C2674218#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [20, 21]}}
{"token": ["C0002395#ent", "<e1>", "treatment", "caused", "a", "marked", "increase", "in", "the", "level", "of", "C1414509#ent", "<e2>", "iron", "that", "was", "accompanied", "by", "degradation", "of", "light", "chain", "iron", "storage", "protein", "ferritin", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1414509", "name": "C1414509#ent", "pos": [11, 12]}}
{"token": ["At", "post-mortem", "both", "a", "C1956391#ent", "<e1>", "the", "congenital", "cardiac", "anomaly", "Tetralogy", "of", "C1418436#ent", "<e2>", "were", "found", "."], "h": {"id": "C1956391", "name": "C1956391#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418436", "name": "C1418436#ent", "pos": [12, 13]}}
{"token": ["C0048134#ent", "<e1>", "a", "potent", "alkylating", "agent", "inhibitor", "of", "phospholipase", "A2", "C0001492#ent", "<e2>", "potentiates", "hydrogen", "peroxide", "production", "in", "human", "platelets", "activated", "with", "thrombin", "."], "h": {"id": "C0048134", "name": "C0048134#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "the", "regulatory", "effect", "C1705526#ent", "<e1>", ",", "on", "the", "spaciotemporal", "recruitment", "XPC", "and", "C1333356#ent", "<e2>", "to", "DNA", "damage", ",", "was", "investigated", "in", "repair-proficient", "and", "-deficient", "human", "cells", "in", "situ"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333356", "name": "C1333356#ent", "pos": [16, 17]}}
{"token": ["HIV-1", "gp120", "binds", "to", "T", "cells", "C1332714#ent", "<e1>", "and", "the", "chemokine", "coreceptor", "C1332823#ent", "<e2>", "(", "fusin/LESTR", ")", "."], "h": {"id": "C1332714", "name": "C1332714#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332823", "name": "C1332823#ent", "pos": [12, 13]}}
{"token": ["In", "the", "serum", ",", "a", "distribution", "of", "C0796055#ent", "<e1>", "specifically", "S-sulfonated", "and", "S-cysteinylated", "forms", "of", "C1421224#ent", "<e2>", ",", "as", "well", "as", "the", "unmodified", "protein", "were", "identified", "."], "h": {"id": "C0796055", "name": "C0796055#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421224", "name": "C1421224#ent", "pos": [15, 16]}}
{"token": ["Since", "PrPSc", "from", "scrapie-infected", "brain", "and", "cultured", "cells", "also", "inefficiently", "released", "from", "membranes", "by", "phospholipase", ",", "resistance", "to", "this", "C0014442#ent", "<e1>", "may", "be", "a", "molecular", "marker", "the", "C0036457#ent", "<e2>", "state", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0036457", "name": "C0036457#ent", "pos": [27, 28]}}
{"token": ["The", "most", "common", "adverse", "effects", "for", "felodipine", ":", "C0018681#ent", "<e1>", ",", "flushing", ",", "ankle", "swelling", "and", "for", "C0014025#ent", "<e2>", ":", "cough", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [17, 18]}}
{"token": ["All", "C1426391#ent", "<e1>", "able", "to", "physically", "interact", "with", "C1414995#ent", "<e2>", "and", "function", "as", "transcriptional", "co-repressors"], "h": {"id": "C1426391", "name": "C1426391#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414995", "name": "C1414995#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "C2350558#ent", "<e1>", "RANK.Fc", "fusion", "protein", "augments", "IFN-gamma", "secretion", "by", "C3540579#ent", "<e2>", "indicating", "the", "occurrence", "of", "reverse", "signaling", "TRANCE", "during", "T", "cell/APC", "interaction", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540579", "name": "C3540579#ent", "pos": [12, 13]}}
{"token": ["We", "have", "investigated", "the", "regulation", "of", "C1706876#ent", "<e1>", "and", "find", "that", ",", "in", "healthy", "cells", "C1706876#ent", "<e1>", "associates", "with", "Mcl-1", "and", "Bcl-x(L", ")", "but", "surprisingly", "not", "C0376515#ent", "<e1>", ",", "Bcl-w", ",", "or", "A1", "."], "h": {"id": "C1706876", "name": "C1706876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [26, 27]}}
{"token": ["There", "was", "no", "significant", "in", "the", "mean", "maximum", "percentage", "fall", "in", "FEV1", "from", "baseline", "after", "exercise", "between", "C1254351#ent", "<e1>", "and", "placebo", "(", "placebo", "30.2", "%", ",", "C0286162#ent", "<e2>", "day", "31.6", "%", ")", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0286162", "name": "C0286162#ent", "pos": [26, 27]}}
{"token": ["Animals", "received", "intramuscularly", "10", "mg/kg", "ketamine", "(", "C2984561#ent", "<e1>", ")", "combined", "with", "0.20", "mg/kg", "medetomidine", "(", "C1413596#ent", "<e2>", ")", ",", "antagonized", "by", "1.00", "mg/kg", "atipamezole", "(", "ATI", ")", "."], "h": {"id": "C2984561", "name": "C2984561#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413596", "name": "C1413596#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "the", "existence", "of", "a", "C1423060#ent", "<e1>", "isoform", "of", "C1424985#ent", "<e2>", "suggests", "a", "role", "in", "spermatogenesis", "."], "h": {"id": "C1423060", "name": "C1423060#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1424985", "name": "C1424985#ent", "pos": [10, 11]}}
{"token": ["A", "homogeneous", "preparation", "of", "C0059114#ent", "<e1>", "rabbit", "brain", "cleaves", "C1415169#ent", "<e2>", "less", "than", "Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2", ")", "at", "the", "Tyr-Gly", "bond", "only", "after", "the", "removal", "of", "Gly-NH2", "from", "the", "COOH-terminal", "position", "the", "molecule", "."], "h": {"id": "C0059114", "name": "C0059114#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [9, 10]}}
{"token": ["The", "patient", "had", "been", "taking", "deferoxamine", "for", "C0018995#ent", "<e1>", ",", "and", "this", "chelating", "agent", "have", "been", "the", "predisposing", "factor", "developing", "C0026718#ent", "<e2>", "."], "h": {"id": "C0018995", "name": "C0018995#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026718", "name": "C0026718#ent", "pos": [20, 21]}}
{"token": ["The", "risks", "and", "benefits", "of", "coxibs", ",", "C0003211#ent", "<e1>", "NSAIDs", ")", ",", "and", "C0004057#ent", "<e2>", "treatment", "are", "under", "intense", "debate", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [7, 8]}, "relation": "structural_class_of", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [13, 14]}}
{"token": ["In", "contrast", ",", "C1413787#ent", "<e1>", "exhibited", "ectopic", "C0795965#ent", "<e2>", "expression", "associated", "with", "root", "vascular", "tissue", "even", "in", "the", "absence", "of", "exogenous", "IAA", "."], "h": {"id": "C1413787", "name": "C1413787#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0795965", "name": "C0795965#ent", "pos": [7, 8]}}
{"token": ["The", "PCR", "products", "subcloned", "and", "sequenced", ",", "and", "one", "of", "these", "clones", "was", "found", "to", "encode", "a", "novel", "C2717971#ent", "<e1>", "named", "tumor-associated", "differentially", "expressed", "gene-14", "(", "C1416679#ent", "<e2>", ")", "."], "h": {"id": "C2717971", "name": "C2717971#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1416679", "name": "C1416679#ent", "pos": [26, 27]}}
{"token": ["We", "now", "provide", "evidence", "that", "the", "mechanism", "of", "neurotoxicity", "of", "two", "other", "amyloidogenic", "peptides", "APs", ")", ",", "human", "amylin", "and", "C1412709#ent", "<e1>", "also", "involves", "induction", "of", "C0289313#ent", "<e2>", "and", "elevation", "of", "[Ca2+]i", "."], "h": {"id": "C1412709", "name": "C1412709#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [26, 27]}}
{"token": ["We", "present", "11", "cases", "(", "16", "C0019559#ent", "<e1>", ")", "of", "neglected", "C1412324#ent", "<e2>", "that", "were", "treated", "operatively", "by", "means", "of", "open", "reduction", "and", "derotational", "subtrochanteric", "osteotomy", "."], "h": {"id": "C0019559", "name": "C0019559#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1412324", "name": "C1412324#ent", "pos": [11, 12]}}
{"token": ["We", "reported", "a", "case", "of", "C0001339#ent", "<e1>", "during", "administration", "of", "valproic", "acid", "C0014547#ent", "<e2>", "."], "h": {"id": "C0001339", "name": "C0001339#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [12, 13]}}
{"token": ["The", "selected", "starch-", "and", "cellulose-based", "polymers", "including", "pre-gelatinized", "starch", "(", "PS", ")", ",", "sodium", "alginate", "sodium", "starch", "glycolate", "C0063242#ent", "<e1>", "HPMC", ")", ",", "sodium", "carboxymethyl", "cellulose", "and", "C0010353#ent", "<e2>", "employed", "."], "h": {"id": "C0063242", "name": "C0063242#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0010353", "name": "C0010353#ent", "pos": [27, 28]}}
{"token": ["This", "stimulation", "could", "not", "be", "reduced", "by", "adding", "PMA", ",", "which", "indicates", "that", "C1259877#ent", "<e1>", "not", "involved", "in", "the", "stimulation", "of", "POMC", "biosynthesis", "by", "C1421143#ent", "<e2>", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1421143", "name": "C1421143#ent", "pos": [24, 25]}}
{"token": ["A", "pharmacogenetic", "interaction", "suggested", "because", "C0001645#ent", "<e1>", "more", "effective", "in", "beta1", "-", "389Arg", "C1706112#ent", "<e2>", "carriers", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [13, 14]}}
{"token": ["Four", "C1418440#ent", "<e1>", "two", "pyruvate", "dehydrogenase", "phosphatase", "isoforms", "function", "in", "adjusting", "the", "activation", "state", "the", "C0034344#ent", "<e2>", "PDC", ")", "through", "determining", "the", "fraction", "of", "active", "(", "nonphosphorylated", ")", "pyruvate", "dehydrogenase", "."], "h": {"id": "C1418440", "name": "C1418440#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034344", "name": "C0034344#ent", "pos": [15, 16]}}
{"token": ["To", "examine", "the", "spatial", "patterning", "the", "individuals", "with", "C0018081#ent", "<e1>", "or", "chlamydia", "infection", "the", "Calgary", "Health", "Region", "(", "C0043459#ent", "<e2>", ")", "to", "target", "prevention", "and", "control", "activities"], "h": {"id": "C0018081", "name": "C0018081#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0043459", "name": "C0043459#ent", "pos": [18, 19]}}
{"token": ["C1705784#ent", "<e1>", "recovery", "was", "enhanced", "in", "patients", "with", "C4255078#ent", "<e2>", "."], "h": {"id": "C1705784", "name": "C1705784#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4255078", "name": "C4255078#ent", "pos": [8, 9]}}
{"token": ["To", "evaluate", "the", "effect", "of", "low", "C0019139#ent", "<e1>", "LMWH", ")", "and", "C0042071#ent", "<e2>", "UK", ")", "on", "unstable", "angina", "UA", ")", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042071", "name": "C0042071#ent", "pos": [11, 12]}}
{"token": ["Consistent", "with", "role", "for", "C1368108#ent", "<e1>", "PI3K", "was", "inhibition", "by", "both", "wortmannin", "and", "C0251991#ent", "<e2>", "(", "p", "<", "0.05", ")", ",", "as", "well", "as", "phosphorylation", "of", "Akt", ",", "while", "MAP", "kinase", "inhibitors", "no", "effect"], "h": {"id": "C1368108", "name": "C1368108#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0251991", "name": "C0251991#ent", "pos": [13, 14]}}
{"token": ["The", "C0020306#ent", "<e1>", "a", "broad", "anti-inflammatory", "activity", "cyclooxygenase", "2", "COX-2", ")", ",", "xanthine", "oxidase", "C1704669#ent", "<e2>", ")", ",", "and", "horseradish", "peroxidase", "HRP", ")", "at", "micromolar", "concentrations", "."], "h": {"id": "C0020306", "name": "C0020306#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704669", "name": "C1704669#ent", "pos": [14, 15]}}
{"token": ["This", "study", "compares", "the", "inotropic", "versus", "relaxation", "response", "cyclic", "AMP-dependent", "and", "cyclic", "AMP-independent", "agents", "in", "myocardium", "from", "patients", "with", "C2316810#ent", "<e1>", "control", "patients", "without", "C0018801#ent", "<e2>"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [24, 25]}}
{"token": ["The", "radical-radical", "distance", "determined", "to", "be", "29.5", "A", "and", "its", "direction", "was", "50", "degrees", "from", "the", "membrane", "normal", "indicating", "that", "a", "chlorophyll", "on", "the", "C1538717#ent", "<e1>", "responsible", "for", "the", "C1366515#ent", "<e2>", "Chlz+", "signal", "."], "h": {"id": "C1538717", "name": "C1538717#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1366515", "name": "C1366515#ent", "pos": [29, 30]}}
{"token": ["In", "the", "network", "meta-analysis", ",", "all", "antiplatelet", "regimens", "(", "C0004057#ent", "<e1>", ",", "C0732279#ent", "<e2>", "thienopyridines", ",", "and", "combination", "of", "C0004057#ent", "<e1>", "and", "thienopyridines", ")", "were", "significantly", "more", "effective", "than", "placebo", "."], "h": {"id": "C0732279", "name": "C0732279#ent", "pos": [12, 13]}, "relation": "has_constitutional_part", "t": {"id": "C0004057", "name": "C0004057#ent", "pos": [9, 10]}}
{"token": ["C1570559#ent", "<e1>", "Pol", "eta", "is", "the", "product", "of", "the", "C1418733#ent", "<e2>", "which", "is", "responsible", "for", "the", "group", "variant", "of", "xeroderma", "pigmentosum", "a", "rare", "inherited", "recessive", "disease", "is", "characterized", "by", "susceptibility", "to", "sunlight-induced", "skin", "cancer", "."], "h": {"id": "C1570559", "name": "C1570559#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1418733", "name": "C1418733#ent", "pos": [9, 10]}}
{"token": ["In", "addition", ",", "cellular", "levels", "C0028123#ent", "<e1>", "present", "in", "freshly", "isolated", "rat", "C0669372#ent", "<e2>", "are", "considerably", "greater", "than", "concentrations", "found", "in", "freshly", "isolated", "rat", "enterocytes", "."], "h": {"id": "C0028123", "name": "C0028123#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [12, 13]}}
{"token": ["On", "further", "phenotypic", "analysis", "these", "cells", "co-expressed", "high", "levels", "of", "TCRV", "beta", "8.1/8.2", "and", "C1366562#ent", "<e1>", ",", "moderate", "levels", "of", "CD90", "and", "low", "levels", "of", "C1332714#ent", "<e2>", "or", "CD8", "."], "h": {"id": "C1366562", "name": "C1366562#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1332714", "name": "C1332714#ent", "pos": [25, 26]}}
{"token": ["In", "the", "Rap", "group", "proteinuria", "was", "more", "severe", "than", "in", "the", "C2829390#ent", "<e1>", ",", "Per", "and", "DHA/Soy", "group", ",", "and", "C1453952#ent", "<e2>", "accumulation", "was", "greater", "than", "in", "the", "other", "groups", "."], "h": {"id": "C2829390", "name": "C2829390#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1453952", "name": "C1453952#ent", "pos": [20, 21]}}
{"token": ["beta-Naphthoflavone", "(", "beta-NF", ")", "and", "rifampicin", "(", "C3890420#ent", "<e1>", ")", "elevated", "the", "levels", "of", "7-ethoxyresorufin", "O-deethylase", "C0059735#ent", "<e2>", ")", "and", "6", "beta-OHP", ",", "respectively", "."], "h": {"id": "C3890420", "name": "C3890420#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [16, 17]}}
{"token": ["C1705079#ent", "<e1>", "levels", "in", "C0003873#ent", "<e2>", "sera", "(", "8.44", "+", "/-", "2.33", ")", "were", "significantly", "greater", "than", "C1705079#ent", "<e1>", "in", "normal", "sera", "0.16", "+", "/-", "0.06", ")", "."], "h": {"id": "C1705079", "name": "C1705079#ent", "pos": [0, 1]}, "relation": "gene_associated_with_disease", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [4, 5]}}
{"token": ["It", "is", "concluded", "that", "intravenous", "C0002575#ent", "<e1>", "in", "patients", "with", "C0948008#ent", "<e2>", "bring", "about", "an", "immediate", "symptomatic", "relief", ",", "but", "without", "appreciably", "influencing", "the", "ultimate", "recovery", "."], "h": {"id": "C0002575", "name": "C0002575#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0948008", "name": "C0948008#ent", "pos": [10, 11]}}
{"token": ["C0021843#ent", "<e1>", "to", "ascariasis", "results", "from", "C0018889#ent", "<e2>"], "h": {"id": "C0021843", "name": "C0021843#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [6, 7]}}
{"token": ["Analysis", "of", "soluble", "and", "C1832370#ent", "<e1>", "fractions", "prepared", "from", "unstressed", "Caco-2", "epithelial", "cells", "that", "C1415760#ent", "<e2>", ",", "and", "to", "a", "lesser", "extent", "calnexin", ",", "were", "present", "in", "C1832370#ent", "<e1>", "fractions", "."], "h": {"id": "C1832370", "name": "C1832370#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [14, 15]}}
{"token": ["Cerebral", "autosomal", "dominant", "arteriopathy", "with", "subcortical", "infarcts", "C0270612#ent", "<e1>", "(", "CADASIL", ")", "is", "a", "C0268790#ent", "<e2>", "associated", "with", "migraines", ",", "recurrent", "ischemic", "strokes", "and", "early-onset", "multiinfarct", "dementia"], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0268790", "name": "C0268790#ent", "pos": [14, 15]}}
{"token": ["The", "response", "to", "C1419178#ent", "<e1>", "was", "inhibited", "by", "diphenylamine", "2-carboxylate", ",", "a", "specific", "C0001641#ent", "<e2>", "of", "the", "Cl-channel", ",", "but", "not", "by", "amiloride", ",", "a", "Na-channel", "blocker"], "h": {"id": "C1419178", "name": "C1419178#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0001641", "name": "C0001641#ent", "pos": [13, 14]}}
{"token": ["Furthermore", ",", "short", "interference", "RNA-mediated", "reduction", "of", "the", "R2", "protein", "a", "marked", "increase", "in", "sensitivity", "to", "the", "DNA-damaging", "agent", "cisplatin", "as", "well", "as", "to", "the", "C3896727#ent", "<e1>", "Triapine", "and", "C0020402#ent", "<e2>", "."], "h": {"id": "C3896727", "name": "C3896727#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [29, 30]}}
{"token": ["Spinal-fluid", "glycine", "concentrations", "were", "15", "to", "30", "times", "above", "normal", "in", "patients", "with", "C0751748#ent", "<e1>", "but", "were", "normal", "in", "those", "with", "C0268559#ent", "<e2>", "of", "undetermined", "type", "who", "had", "comparable", "elevations", "of", "plasma", "glycine"], "h": {"id": "C0751748", "name": "C0751748#ent", "pos": [13, 14]}, "relation": "has_manifestation", "t": {"id": "C0268559", "name": "C0268559#ent", "pos": [21, 22]}}
{"token": ["C0019348#ent", "<e1>", "to", "be", "the", "most", "common", "C0042769#ent", "<e2>", "the", "hand", "."], "h": {"id": "C0019348", "name": "C0019348#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["Further", "studies", "suggest", "that", "v-Src", "phosphorylation", "sites", "on", "C1412753#ent", "<e1>", "are", "critical", "for", "its", "binding", "to", "C2984552#ent", "<e2>", "and", "Csk", ",", "negative", "regulators", "Src", "signaling"], "h": {"id": "C1412753", "name": "C1412753#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2984552", "name": "C2984552#ent", "pos": [16, 17]}}
{"token": ["Changes", "in", "the", "expression", "of", "C1412515#ent", "<e1>", "and", "their", "association", "with", "nitrosative", "stress", "investigated", "using", "an", "C0004096#ent", "<e2>", "established", "in", "NC/Nga", "mice", "with", "mite", "extract"], "h": {"id": "C1412515", "name": "C1412515#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["The", "contribution", "of", "lupus", "anticoagulant", "to", "the", "pathogenesis", "of", "C0242380#ent", "<e1>", "systemic", "lupus", "erythematosus", "and", "its", "possible", "relationship", "to", "C2363973#ent", "<e2>", "discussed", "."], "h": {"id": "C0242380", "name": "C0242380#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2363973", "name": "C2363973#ent", "pos": [19, 20]}}
{"token": ["When", "cumulated", "with", "previously", "published", "results", "with", "overlapping", "families", "removed", ",", "the", "affected-sib-pair", "tests", "had", "a", "significance", "of", "P", "=", ".0001", "for", "C1838260#ent", "<e1>", "and", "P", "=", ".00004", "for", "C1415873#ent", "<e2>", "."], "h": {"id": "C1838260", "name": "C1838260#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1415873", "name": "C1415873#ent", "pos": [29, 30]}}
{"token": ["These", "are", "the", "major", "phenotypes", "observed", "during", "the", "aging", "of", "worms", ",", "suggesting", "that", "the", "reduction", "of", "C3539602#ent", "<e1>", "causes", "early", "aging", "or", "C0009207#ent", "<e2>", "phenotypes", "."], "h": {"id": "C3539602", "name": "C3539602#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [23, 24]}}
{"token": ["There", "were", "13", "cases", "of", "invasive", "pulmonary", "aspergillosis", "two", "cases", "of", "C0276651#ent", "<e1>", ",", "and", "two", "cases", "of", "C0043541#ent", "<e2>", "."], "h": {"id": "C0276651", "name": "C0276651#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0043541", "name": "C0043541#ent", "pos": [18, 19]}}
{"token": ["In", "the", "C2936904#ent", "<e1>", "Carney", "complex", "intracardiac", "myxomas", "in", "the", "setting", "of", "C0031269#ent", "<e2>", "and", "other", "lesions", "associated", "with", "cutaneous", "hyperpigmentation", "extracardiac", "myxomas", "and", "nonmyxomatous", "tumors", "."], "h": {"id": "C2936904", "name": "C2936904#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031269", "name": "C0031269#ent", "pos": [12, 13]}}
{"token": ["Human", "T-cell", "lymphotropic", "virus", "type", "1", "HTLV-1", ")", ",", "causes", "adult", "C0796355#ent", "<e1>", "ATLL", ")", ",", "and", "initiates", "a", "variety", "of", "C1334156#ent", "<e2>"], "h": {"id": "C0796355", "name": "C0796355#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334156", "name": "C1334156#ent", "pos": [21, 22]}}
{"token": ["The", "inhibitory", "effects", "of", "absence", "of", "metabolic", "substrate", "and", "iodoacetic", "acid", "removed", "by", "reexposure", "to", "glucose", "and", "C0281255#ent", "<e1>", "and", "by", "exogenous", "C2744579#ent", "<e2>", ",", "respectively.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0281255", "name": "C0281255#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [22, 23]}}
{"token": ["Her", "father", ",", "an", "obligate", "apo-E3-deficient", "heterozygote", ",", "and", "his", "similarly", "affected", "brother", "died", "prematurely", "with", "severe", "C0020443#ent", "<e1>", "which", "had", "been", "refractory", "to", "C0009002#ent", "<e2>", "."], "h": {"id": "C0020443", "name": "C0020443#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0009002", "name": "C0009002#ent", "pos": [24, 25]}}
{"token": ["Cerebrotendinous", "xanthomatosis", "CTX", ")", "is", "a", "hereditary", "disorder", "which", "is", "inherited", "as", "an", "C3899988#ent", "<e1>", "causing", "production", "of", "cholesterol", "and", "C0302314#ent", "<e2>", "mental", "retardation"], "h": {"id": "C3899988", "name": "C3899988#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0302314", "name": "C0302314#ent", "pos": [20, 21]}}
{"token": ["In", "the", "longitudinal", "muscle", "the", "contractile", "responses", "SFLLRN-NH2", "and", "C0675133#ent", "<e1>", "were", "significantly", "reduced", "by", "nifedipine", ",", "an", "L-type", "calcium", "channel", "blocker", "C0035983#ent", "<e2>", ",", "GF109203X", ",", "genistein", ",", "and", "abolished", "by", "U73122", "."], "h": {"id": "C0675133", "name": "C0675133#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035983", "name": "C0035983#ent", "pos": [22, 23]}}
{"token": ["In", "conclusion", ",", "C1417826#ent", "<e1>", "(", "A7635", "G", ")", "rather", "than", "C3714750#ent", "<e2>", "or", "ABCB1", "allelic", "variants", "affected", "patient", "variability", "of", "plasma", "prednisolone", "concentration", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714750", "name": "C3714750#ent", "pos": [11, 12]}}
{"token": ["Low-renin", "C0598428#ent", "<e1>", "hypokalemia", "encompass", "C3838731#ent", "<e2>", "in", "which", "aldosterone", "levels", "are", "elevated", ",", "and", "familial", "pseudohyperaldosteronisms", "mimicking", "aldosteronism", "despite", "appropriately", "suppressed", "aldosterone", "levels", "."], "h": {"id": "C0598428", "name": "C0598428#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3838731", "name": "C3838731#ent", "pos": [5, 6]}}
{"token": ["WW", "domains", "the", "essential", "mitotic", "prolyl", "isomerase", "Pin1", "and", "the", "ubiquitin", "ligase", "C1417659#ent", "<e1>", "bound", "to", "phosphoproteins", ",", "including", "physiological", "substrates", "of", "C3541394#ent", "<e2>", ",", "in", "a", "phosphorylation-dependent", "manner", "."], "h": {"id": "C1417659", "name": "C1417659#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [22, 23]}}
{"token": ["On", "the", "other", "hand", ",", "microvascularly-localized", "agents", "like", "C0245179#ent", "<e1>", "appear", "to", "have", "better", "ability", "to", "limit", "C1801950#ent", "<e2>", "damage", "."], "h": {"id": "C0245179", "name": "C0245179#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1801950", "name": "C1801950#ent", "pos": [17, 18]}}
{"token": ["Charcot-Marie-Tooth", "type", "4C4", "disease", "C1866636#ent", "<e1>", ")", "is", "an", "early", "onset", "C1850386#ent", "<e2>", "hoarseness", "caused", "by", "mutations", "in", "the", "GDAP1", "gene", "maps", "to", "the", "8q13", "region", "."], "h": {"id": "C1866636", "name": "C1866636#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1850386", "name": "C1850386#ent", "pos": [11, 12]}}
{"token": ["We", "conclude", "that", "the", "elevated", "respiratory", "burst", "PMN", "in", "C0033860#ent", "<e1>", "normalizes", "under", "treatment", "with", "both", "C0050559#ent", "<e2>", "and", "CyA."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0050559", "name": "C0050559#ent", "pos": [16, 17]}}
{"token": ["The", "major", "fatty", "acyl", "constituents", "are", "palmitic", ",", "stearic", ",", "C0028928#ent", "<e1>", ",", "and", "linoleic", "acids", "cerebrosides", ",", "C0007804#ent", "<e2>", "and", "two", "kinds", "of", "gangliosides", "are", "also", "found", "in", "the", "NDV", "membrane", "."], "h": {"id": "C0028928", "name": "C0028928#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [18, 19]}}
{"token": ["When", "compared", "with", "native", "C0009325#ent", "<e1>", ",", "early", "passage", "showed", "increased", "p53", ",", "p21(CIP1", ")", "(", "C0079471#ent", "<e2>", ")", ",", "and", "p16(INK4a", ")", "(", "p16", ")", "mRNA", "expression", "after", "exposure", "to", "GC", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079471", "name": "C0079471#ent", "pos": [16, 17]}}
{"token": ["Field", "loss", "neovascular", "glaucoma", "optic", "atrophy", "C0152222#ent", "<e1>", "hemiparesis", ",", "hemiplegia", ",", "and", "proptosis", "may", "be", "associated", "with", "C0812228#ent", "<e2>", "."], "h": {"id": "C0152222", "name": "C0152222#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [18, 19]}}
{"token": ["C3273763#ent", "<e1>", "inflammation", "is", "the", "predominant", "underlying", "mechanism", "in", "chronic", "obstructive", "pulmonary", "disease", "C1647218#ent", "<e2>", ")", "."], "h": {"id": "C3273763", "name": "C3273763#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1647218", "name": "C1647218#ent", "pos": [13, 14]}}
{"token": ["Involvement", "of", "nervous", "system", "toxocariasis", "is", "rare", "and", "can", "produce", "a", "spectrum", "of", "pathology", "that", "includes", "C0221397#ent", "<e1>", "meningomyelitis", ",", "space", "occupying", "lesions", ",", "vasculitis", "causing", "C0036572#ent", "<e2>", "or", "behavioral", "abnormalities", "diagnostic", "dilemmas", "."], "h": {"id": "C0221397", "name": "C0221397#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [26, 27]}}
{"token": ["This", "has", "also", "been", "demonstrated", "in", "an", "analysis", "comparing", "C0795650#ent", "<e1>", "to", "both", "omeprazoles", ",", "with", "C0795650#ent", "<e1>", "showing", "superior", "relief", "of", "C0018834#ent", "<e1>", "patients", "with", "GERD", "."], "h": {"id": "C0795650", "name": "C0795650#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0018834", "name": "C0018834#ent", "pos": [22, 23]}}
{"token": ["Although", "salbutamol", "may", "be", "infused", "safely", "for", "a", "prolonged", "period", "to", "patients", "with", "C0004096#ent", "<e1>", "it", "has", "no", "particular", "advantage", "over", "C0002575#ent", "<e2>", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [13, 14]}, "relation": "may_be_treated_by", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [21, 22]}}
{"token": ["Pharmacokinetic", "studies", "theophylline", "were", "carried", "out", "in", "12", "Thai", "C0004096#ent", "<e1>", "children", "after", "oral", "administration", "Elixir", "Quibron", "Tablet", "C0002575#ent", "<e2>", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [18, 19]}}
{"token": ["We", "investigated", "the", "effect", "of", "interleukin", "1beta", "IL-1beta", ")", "on", "C3710940#ent", "<e1>", "C1420490#ent", "<e2>", ")", "activity", "and", "the", "expression", "of", "C1420490#ent", "<e2>", "mRNA", "in", "human", "endometrial", "stromal", "cells"], "h": {"id": "C3710940", "name": "C3710940#ent", "pos": [10, 11]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420490", "name": "C1420490#ent", "pos": [12, 13]}}
{"token": ["This", "is", "the", "first", "study", "of", "the", "effects", "of", "rapid", "correction", "(", "9", "h", ")", "of", "C0268007#ent", "<e1>", "3", "d", ")", "on", "brain", "electrolyte", "water", ",", "and", "C2917660#ent", "<e2>", "contents", "in", "young", "mice", "."], "h": {"id": "C0268007", "name": "C0268007#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [27, 28]}}
{"token": ["We", "studied", "the", "clinical", "effectiveness", "C0722495#ent", "<e1>", "in", "dilating", "heavily", "pigmented", "eyes", "by", "comparing", "its", "C0026964#ent", "<e2>", "efficacy", "in", "Blacks", ",", "Asians", "and", "Caucasians", "with", "light", "and", "dark", "brown", "irides", "."], "h": {"id": "C0722495", "name": "C0722495#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026964", "name": "C0026964#ent", "pos": [15, 16]}}
{"token": ["Familial", "hypobetalipoproteinaemia", "C1862596#ent", "<e1>", ")", "is", "an", "autosomal", "C0019247#ent", "<e2>", "lipoprotein", "metabolism", "by", "decreased", "low", "density", "lipoprotein", "LDL", ")", "cholesterol", "and", "apolipoprotein", "B", "APOB", ")", "plasma", "levels"], "h": {"id": "C1862596", "name": "C1862596#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0019247", "name": "C0019247#ent", "pos": [8, 9]}}
{"token": ["Changes", "in", "C0085593#ent", "<e1>", "resistance", "were", "analyzed", "under", "fluctuating", "temperatures", "and", "C2984561#ent", "<e2>", ",", "and", "explained", "taking", "into", "consideration", "the", "functioning", "of", "the", "circadian", "clock", "environmental", "induction", "resistance", "."], "h": {"id": "C0085593", "name": "C0085593#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2984561", "name": "C2984561#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "C0538724#ent", "<e1>", "acts", "as", "a", "C2984537#ent", "<e2>", "agonist", "in", "hepatocytes", "and", "that", "C0538724#ent", "<e1>", "may", "improve", "lipid", "abnormality", "C2984537#ent", "<e2>", "activation", "in", "the", "liver", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0538724", "name": "C0538724#ent", "pos": [4, 5]}}
{"token": ["Nitrous", "oxide", "a", "C0304402#ent", "<e1>", "effect", "on", "cerebral", "metabolism", "is", "associated", "with", "increase", "in", "C1428360#ent", "<e2>", "."], "h": {"id": "C0304402", "name": "C0304402#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [14, 15]}}
{"token": ["This", "method", "yields", "membranous", "vesicles", "contain", ",", "in", "addition", "to", "C1415014#ent", "<e1>", ",", "uridylyl-transferase", ",", "phosphoglucomutase", ",", "sialyl-transferase", "and", "C1382029#ent", "<e2>"], "h": {"id": "C1415014", "name": "C1415014#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1382029", "name": "C1382029#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "we", "found", "that", "expression", "of", "two", "of", "these", "potential", "targets", ",", "the", "C0169661#ent", "<e1>", "and", "thyroid", "hormone", "receptor", "beta2", "genes", "was", "lost", "in", "the", "neuroendocrine", "hypothalamus", "the", "C1420067#ent", "<e2>", "mutant", "."], "h": {"id": "C0169661", "name": "C0169661#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420067", "name": "C1420067#ent", "pos": [29, 30]}}
{"token": ["The", "ratio", "of", "C0017723#ent", "<e1>", "glucosamine", "was", "higher", "in", "the", "C2697656#ent", "<e2>", "of", "the", "non-nodulating", "strain", "SM", "15", "than", "in", "the", "corresponding", "material", "of", "the", "nodulating", "one", "."], "h": {"id": "C0017723", "name": "C0017723#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [10, 11]}}
{"token": ["The", "greatest", "number", "of", "second-stage", "juveniles", "(", "C1416167#ent", "<e1>", ")", "occurred", "on", "Guatemalan", "and", "fewest", "C1416167#ent", "<e1>", "on", "C0034150#ent", "<e1>", "and", "Deweveri", "rootstocks", "."], "h": {"id": "C1416167", "name": "C1416167#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034150", "name": "C0034150#ent", "pos": [18, 19]}}
{"token": ["Heat", "shock", "protein", "C1333928#ent", "<e1>", ")", "is", "a", "cytoskeleton-interacting", "substrate", "of", "C1452441#ent", "<e2>", "."], "h": {"id": "C1333928", "name": "C1333928#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1452441", "name": "C1452441#ent", "pos": [11, 12]}}
{"token": ["C1826449#ent", "<e1>", "and", "its", "downstream", "effector", "C1706435#ent", "<e2>", "associated", "with", "activated", "TAK1", "."], "h": {"id": "C1826449", "name": "C1826449#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1706435", "name": "C1706435#ent", "pos": [6, 7]}}
{"token": ["Drug-dose", "enhancement", "ratios", "were", "1.6", ",", "2.8", ",", "2", ",", "and", "1:1", "for", "C0007257#ent", "<e1>", ",", "AZQ", ",", "cis-DDP", ",", "and", "C0075019#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0007257", "name": "C0007257#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0075019", "name": "C0075019#ent", "pos": [21, 22]}}
{"token": ["The", "assay", "is", "based", "on", "kinetic", "analysis", "irreversible", "C0008429#ent", "<e1>", "inhibition", "by", "the", "organophosphorus", "compound", "N", "N'-di-isopropylphosphorodiamidic", "fluoride", "(", "C0066579#ent", "<e2>", ")", "."], "h": {"id": "C0008429", "name": "C0008429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0066579", "name": "C0066579#ent", "pos": [19, 20]}}
{"token": ["Although", "the", "FLI", "LRR", "module", "is", "most", "closely", "related", "to", "the", "LRR", "domains", "C1428404#ent", "<e1>", "FLI", "does", "not", "associate", "with", "C0525678#ent", "<e2>", ",", "selected", "Ras", "effectors", "or", "other", "Ras-related", "small", "GTPases"], "h": {"id": "C1428404", "name": "C1428404#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0525678", "name": "C0525678#ent", "pos": [20, 21]}}
{"token": ["On", "the", "other", "hand", ",", "when", "cholinergic", "neurons", "are", "cultured", "on", "a", "preformed", "layer", "of", "astrocytes", ",", "addition", "of", "basal", "fibroblast", "growth", "factor", "C1522505#ent", "<e1>", ")", "failed", "to", "increase", "further", "the", "C0124604#ent", "<e2>", "activity", "."], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [31, 32]}}
{"token": ["Interestingly", ",", "these", "cells", "have", "maintained", "not", "only", "the", "expression", "of", "C2698421#ent", "<e1>", "but", "also", "that", "of", "C1417820#ent", "<e2>", "."], "h": {"id": "C2698421", "name": "C2698421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417820", "name": "C1417820#ent", "pos": [17, 18]}}
{"token": ["We", "report", "a", "case", "of", "C0001261#ent", "<e1>", "of", "the", "prostate", "with", "symptoms", "of", "C0149524#ent", "<e2>"], "h": {"id": "C0001261", "name": "C0001261#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0149524", "name": "C0149524#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "the", "determination", "of", "the", "C0376565#ent", "<e1>", "lopinavir", ",", "and", "C0939237#ent", "<e2>", "concentration", "in", "the", "plasma", "of", "HIV-infected", "patients", "by", "MALDI-TOF/TOF", "is", "reported", "."], "h": {"id": "C0376565", "name": "C0376565#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0939237", "name": "C0939237#ent", "pos": [11, 12]}}
{"token": ["C0019937#ent", "<e1>", "associated", "with", "decreased", "sensitivity", "of", "peripheral", "blood", "mononuclear", "cells", "GH", "and", "to", "C1334089#ent", "<e2>", ",", "as", "is", "evident", "by", "the", "reduction", "in", "LDL", "degradation", ",", "monocyte-stimulated", "T-lymphocyte", "proliferation", "IL-2", "secretion", "by", "blastoid", "T", "cells"], "h": {"id": "C0019937", "name": "C0019937#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [14, 15]}}
{"token": ["Other", "C2985420#ent", "<e1>", "such", "as", "C1367475#ent", "<e2>", ",", "FcRgamma", ",", "and", "Thy-1", ",", "had", "no", "effect", "on", "the", "CD3-dependent", "proliferation", "of", "day", "16", "fetal", "thymocytes", "."], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1367475", "name": "C1367475#ent", "pos": [5, 6]}}
{"token": ["Valproate", "(", "VPA", ")", "is", "usually", "regarded", "as", "the", "C1254351#ent", "<e1>", "of", "choice", "in", "idiopathic", "generalized", "epilepsies", "C1840252#ent", "<e2>", ")", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1840252", "name": "C1840252#ent", "pos": [17, 18]}}
{"token": ["The", "regional", "distribution", "of", "C1743818#ent", "<e1>", "ALDH", ")", "and", "C0001942#ent", "<e2>", "activities", "in", "mouse", "ocular", "tissues", "examined", "using", "spectrophotometric", "and", "agarose-isoelectric", "focusing", "techniques", "."], "h": {"id": "C1743818", "name": "C1743818#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001942", "name": "C0001942#ent", "pos": [9, 10]}}
{"token": ["C0206062#ent", "<e1>", "inactive", "calcifications", "present", "primarily", "with", "C0751495#ent", "<e2>", ";", "ventricular", "disease", "headaches", "and", "symptoms", "of", "acute", "hydrocephalus", "and", "cisternal", "disease", "with", "basilar", "meningitis", "hydrocephalus", ",", "or", "C0751495#ent", "<e2>", "from", "coexisting", "parenchymal", "disease"], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [7, 8]}}
{"token": ["The", "chemical", "model", "system", "therefore", "used", "on", "a", "microscale", "to", "react", "AFB1", "with", "plasmid", "pHR1800", ",", "a", "plasmid", "containing", "the", "C1417679#ent", "<e1>", "for", "beta-lactamase", "(", "amp-r", ")", "and", "C1414948#ent", "<e2>", "(", "galK", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1414948", "name": "C1414948#ent", "pos": [28, 29]}}
{"token": ["Unlike", "the", "tachykinins", ",", "C1367551#ent", "<e1>", "per", "se", "was", "without", "effect", "on", "the", "C0034124#ent", "<e2>", "disrupting", "the", "blood-aqueous", "barrier", "resulting", "in", "aqueous", "flare", ")", "upon", "intravitreal", "injection", "."], "h": {"id": "C1367551", "name": "C1367551#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034124", "name": "C0034124#ent", "pos": [13, 14]}}
{"token": ["On", "the", "other", "hand", ",", "her7", ",", "a", "member", "of", "the", "hairy/Enhancer-of-split", "related", "Her", ")", "C1517488#ent", "<e1>", "shows", "cyclic", "expression", "the", "medaka", "C1310550#ent", "<e2>", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1310550", "name": "C1310550#ent", "pos": [22, 23]}}
{"token": ["Methyladenine", "was", "present", "in", "the", "C1705846#ent", "<e1>", "sequence", "of", "DNA", "from", "15", "C0037974#ent", "<e2>", "of", "human", "origin", ",", "and", "methylcytosine", "was", "present", "in", "several", "sequences", "occurring", "in", "all", "strains", "."], "h": {"id": "C1705846", "name": "C1705846#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0037974", "name": "C0037974#ent", "pos": [12, 13]}}
{"token": ["Previous", "work", "has", "shown", "that", "soluble", "heat", "shock", "protein", "60", "HSP60", ";", "C3538704#ent", "<e1>", ")", ",", "present", "in", "circulating", "blood", "is", "associated", "with", "C0577631#ent", "<e2>"], "h": {"id": "C3538704", "name": "C3538704#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0577631", "name": "C0577631#ent", "pos": [23, 24]}}
{"token": ["Also", ",", "are", "some", "people", "more", "C1516876#ent", "<e1>", "at", "risk", "for", "acquiring", "variant", "C2347435#ent", "<e2>", "than", "others", "?"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2347435", "name": "C2347435#ent", "pos": [13, 14]}}
{"token": ["Both", "C0699930#ent", "<e1>", "and", "Evoxac", "are", "FDA", "approved", "C0304402#ent", "<e2>"], "h": {"id": "C0699930", "name": "C0699930#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0304402", "name": "C0304402#ent", "pos": [8, 9]}}
{"token": ["A", "eukaryotic", "3-methyladenine", "DNA", "glycosylase", "gene", "the", "Saccharomyces", "cerevisiae", "C1416969#ent", "<e1>", "gene", ",", "was", "shown", "to", "prevent", "C0023972#ent", "<e2>", "toxicity", "."], "h": {"id": "C1416969", "name": "C1416969#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023972", "name": "C0023972#ent", "pos": [17, 18]}}
{"token": ["These", "results", "indicate", "that", "circulating", "C0002842#ent", "<e1>", "are", "exerting", "a", "down-regulation", "of", "pro", "C1421413#ent", "<e2>", "expression", "possibly", "by", "a", "direct", "action", "at", "the", "level", "of", "motoneurons", "."], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1421413", "name": "C1421413#ent", "pos": [13, 14]}}
{"token": ["In", "vivo", "interaction", "between", "the", "C1705287#ent", "<e1>", "and", "SAD", "C0086376#ent", "<e2>", "was", "shown", "in", "the", "yeast", "two-hybrid", "system", "where", "C1705287#ent", "<e1>", "potentiates", "the", "SAD", "trans-activation", "capacity", "through", "interaction", "with", "its", "C-terminal", "domain"], "h": {"id": "C1705287", "name": "C1705287#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [9, 10]}}
{"token": ["Microarray", "gene", "C0072074#ent", "<e1>", "was", "used", "to", "examine", "the", "role", "of", "C3890008#ent", "<e2>", "in", "the", "light", "control", "Arabidopsis", "genome", "expression"], "h": {"id": "C0072074", "name": "C0072074#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3890008", "name": "C3890008#ent", "pos": [11, 12]}}
{"token": ["To", "determine", "the", "diagnostic", "value", "empirical", "treatment", "C0028978#ent", "<e1>", "in", "the", "diagnosis", "of", "gastroesophageal", "reflux", "disease", "C0017168#ent", "<e2>", ")", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0017168", "name": "C0017168#ent", "pos": [16, 17]}}
{"token": ["The", "diagnosis", "of", "C3536715#ent", "<e1>", "not", "be", "made", "in", "eight", "patients", "with", "pediatric", "C0035435#ent", "<e2>", "later", "verified", "employing", "the", "more", "sensitive", "combination", "of", "Congo", "red", "additional", "immunocytochemistry", "(", "CRIC", ")", "."], "h": {"id": "C3536715", "name": "C3536715#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035435", "name": "C0035435#ent", "pos": [13, 14]}}
{"token": ["The", "three-dimensional", "structures", "tryptophan", "synthase", "carbamoyl", "phosphate", "synthetase", "C1418780#ent", "<e1>", "and", "asparagine", "synthetase", "revealed", "the", "relative", "locations", "of", "multiple", "active", "sites", "these", "C0086376#ent", "<e2>", "."], "h": {"id": "C1418780", "name": "C1418780#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [22, 23]}}
{"token": ["C0035690#ent", "<e1>", "the", "most", "common", "human", "diseases", "particularly", "C0035243#ent", "<e2>", "mostly", "in", "children", "and", "young", "adults", "."], "h": {"id": "C0035690", "name": "C0035690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [8, 9]}}
{"token": ["A", "few", "neurons", "in", "the", "pontine", "reticular", "formation", "nucleus", "coeruleus", "labeled", "by", "horseradish", "peroxidase", "C3889156#ent", "<e1>", ")", "injections", "of", "the", "thoracic", "cord", "early", "as", "postnatal", "day", "C1956415#ent", "<e2>", ")", "3", "."], "h": {"id": "C3889156", "name": "C3889156#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1956415", "name": "C1956415#ent", "pos": [26, 27]}}
{"token": ["The", "C0935989#ent", "<e1>", "effect", "was", "mimicked", "by", "siRNA-mediated", "knockdown", "of", "C1704928#ent", "<e2>", "mRNA", "."], "h": {"id": "C0935989", "name": "C0935989#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1704928", "name": "C1704928#ent", "pos": [10, 11]}}
{"token": ["Levels", "of", "C1334706#ent", "<e1>", "and", "TIMP-1", "mRNA", "expression", "in", "progeria", "and", "C1333359#ent", "<e2>", "similar", "to", "those", "of", "early-passage", "cell", "cultures", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333359", "name": "C1333359#ent", "pos": [11, 12]}}
{"token": ["However", ",", "immunoprecipitation", "of", "EHV-3", "infected", "cell", "extracts", "polyvalent", "rabbit", "antisera", "to", "C1705742#ent", "<e1>", "of", "EHV-1", "revealed", "at", "least", "two", "other", "viral", "specific", "IE", "C1305923#ent", "<e2>", "."], "h": {"id": "C1705742", "name": "C1705742#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [24, 25]}}
{"token": ["C0043528#ent", "<e1>", "such", "as", "C0036262#ent", "<e2>", ",", "lice", "and", "cimicosis", "are", "common", ",", "vexing", "disorders", "that", "occur", "worldwide", "."], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C0036262", "name": "C0036262#ent", "pos": [4, 5]}}
{"token": ["PDGF", ",", "C1420314#ent", "<e1>", "and", "bFGF", "stimulated", "cell", "migration", "and", "enhanced", "the", "expression", "of", "C1367469#ent", "<e2>", "mRNA", "in", "the", "human", "lung", "adenocarcinoma", "cell", "line", "A549", "."], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1367469", "name": "C1367469#ent", "pos": [14, 15]}}
{"token": ["The", "genes", "located", "between", "IMPA1", "and", "C1539715#ent", "<e1>", "are", "the", "most", "likely", "candidates", "for", "C0162674#ent", "<e2>"], "h": {"id": "C1539715", "name": "C1539715#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0162674", "name": "C0162674#ent", "pos": [14, 15]}}
{"token": ["The", "complex", "consists", "of", "a", "C1417509#ent", "<e1>", "MVP", ")", ",", "two", "minor", "vault", "proteins", "(", "C0042291#ent", "<e2>", "and", "TEP1", ")", ",", "and", "several", "small", "untranslated", "RNA", "molecules"], "h": {"id": "C1417509", "name": "C1417509#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [15, 16]}}
{"token": ["Recent", "studies", "suggest", "that", "mitochondrial", "aldehyde", "dehydrogenase", "C1705626#ent", "<e1>", ")", "plays", "a", "central", "role", "in", "the", "process", "of", "C0017887#ent", "<e2>", "(", "glyceryl", "trinitrate", "GTN", ")", "biotransformation", "in", "vivo", "that", "its", "inhibition", "accounts", "for", "mechanism-based", "tolerance", "in", "vitro"], "h": {"id": "C1705626", "name": "C1705626#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017887", "name": "C0017887#ent", "pos": [18, 19]}}
{"token": ["Progesterone", "production", "in", "vitro", "in", "the", "presence", "and", "absence", "of", "exogenous", "C3536870#ent", "<e1>", ",", "was", "examined", "in", "suspensions", "of", "luteal", "cells", "isolated", "by", "C0172956#ent", "<e2>", "rhesus", "monkeys", "corpus", "luteum", "various", "stages", "of", "the", "menstrual", "cycle"], "h": {"id": "C3536870", "name": "C3536870#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0172956", "name": "C0172956#ent", "pos": [23, 24]}}
{"token": ["The", "human", "homologue", "of", "C3810629#ent", "<e1>", "is", "located", "on", "chromosome", "8p21.2", "encodes", "a", "C1413488#ent", "<e2>", "PDLIM2", ")", "."], "h": {"id": "C3810629", "name": "C3810629#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413488", "name": "C1413488#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "C0017337#ent", "<e1>", "coding", "these", "proteins", "result", "in", "conformational", "disturbances", "the", "C0175168#ent", "<e2>", "their", "accumulation", "and", "aggregation", "manifesting", "at", "the", "level", "of", "light", "microscope", "various", "intracellular", "inclusions", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0175168", "name": "C0175168#ent", "pos": [12, 13]}}
{"token": ["BCMA", "and", "TACI", "additionally", "bind", "C3715025#ent", "<e1>", "(", "a", "proliferation-inducing", "ligand", ",", "the", "TNF", "family", "ligand", "C1512488#ent", "<e2>", "to", "BAFF", "."], "h": {"id": "C3715025", "name": "C3715025#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [16, 17]}}
{"token": ["As", "a", "result", "of", "the", "high", "degree", "of", "condensation", "and", "inactivation", "of", "spermatid", "and", "C0008546#ent", "<e1>", "Sertoli", "cells", "responsible", "for", "the", "C0162429#ent", "<e2>", "of", "germ", "cells", "ribosomal", "RNA", "nutritive", "substances"], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [21, 22]}}
{"token": ["The", "C0023138#ent", "<e1>", "characterized", "by", "retinitis", "pigmentosa", "obesity", ",", "psychic", "disturbances", "polydactily", "and", "C0151721#ent", "<e2>", "."], "h": {"id": "C0023138", "name": "C0023138#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0151721", "name": "C0151721#ent", "pos": [13, 14]}}
{"token": ["This", "study", "examined", "the", "influence", "of", "a", "repeat", "length", "in", "the", "promoter", "region", "the", "5-HTT", "gene", "C1367456#ent", "<e1>", "between", "patients", "with", "C1313497#ent", "<e2>", "and", "healthy", "control", "participants", "."], "h": {"id": "C1367456", "name": "C1367456#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1313497", "name": "C1313497#ent", "pos": [21, 22]}}
{"token": ["Risperidone", "and", "C0771848#ent", "<e1>", "are", "both", "metabolized", "through", "C3887685#ent", "<e2>", "3A4", ",", "raising", "the", "possibility", "of", "drug", "interactions", "combination", "therapy"], "h": {"id": "C0771848", "name": "C0771848#ent", "pos": [2, 3]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [8, 9]}}
{"token": ["cDNAs", "encoding", "three", "alpha-glucosidases", "(", "C2827563#ent", "<e1>", "II", ",", "and", "III", ")", "from", "European", "honeybees", ",", "C0939871#ent", "<e2>", "were", "cloned", "and", "sequenced", ",", "two", "of", "which", "were", "expressed", "in", "Pichia", "pastoris", "."], "h": {"id": "C2827563", "name": "C2827563#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0939871", "name": "C0939871#ent", "pos": [16, 17]}}
{"token": ["The", "rise", "in", "intracellular", "calcium", "induced", "by", "C1705725#ent", "<e1>", "stimulation", "was", "also", "inhibited", "by", "native", "C1415692#ent", "<e2>", "."], "h": {"id": "C1705725", "name": "C1705725#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [15, 16]}}
{"token": ["Elimination", "of", "the", "e2", "glycosylation", "site", "missing", "in", "the", "monoglycosylated", "TRPC3", ",", "was", "sufficient", "to", "convert", "the", "tightly", "C3828360#ent", "<e1>", "TRPC6", "into", "a", "C0907533#ent", "<e2>", "active", "channel", "displaying", "functional", "characteristics", "of", "TRPC3", "."], "h": {"id": "C3828360", "name": "C3828360#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [23, 24]}}
{"token": ["The", "chloroform", "extract", "CHE", ")", "shared", "almost", "all", "the", "same", "C0015230#ent", "<e1>", "with", "the", "PEF", "and", "C0019099#ent", "<e2>", "and", "was", "plentiful", "enough", "to", "carry", "out", "further", "separations", "."], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [16, 17]}}
{"token": ["The", "C0289579#ent", "<e1>", "the", "second", "largest", "family", "of", "mammalian", "C0387990#ent", "<e2>", "are", "distinguished", "by", "the", "presence", "of", "distinct", "proline-rich", "regions", "pleckstrin", "homology", "domains", "are", "required", "for", "proper", "regulation", "and", "activation", "."], "h": {"id": "C0289579", "name": "C0289579#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0387990", "name": "C0387990#ent", "pos": [9, 10]}}
{"token": ["To", "examine", "the", "costs", "and", "benefits", "associated", "with", "long-term", "C0717758#ent", "<e1>", "(", "ETN", ")", "treatment", "in", "patients", "with", "severe", "C0038013#ent", "<e2>", "AS", ")", "in", "the", "UK", "in", "accordance", "with", "the", "BSR", "guidelines", "."], "h": {"id": "C0717758", "name": "C0717758#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [19, 20]}}
{"token": ["This", "study", "investigated", "and", "compared", "the", "gait", "of", "two", "patients", "with", "spinal", "muscular", "atrophy", "type", "II", "C0393538#ent", "<e1>", "and", "two", "patients", "with", "C0013264#ent", "<e2>", "DMD", ")", "."], "h": {"id": "C0393538", "name": "C0393538#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0013264", "name": "C0013264#ent", "pos": [22, 23]}}
{"token": ["Bovine", "parathyroid", "A", "inhibits", "the", "cleavage", "of", "Z-Ala-Lys-Arg-AMC", "by", "either", "trypsin", "or", "C0063848#ent", "<e1>", "IRCM-SP1", ")", ",", "a", "putative", "novel", "processing", "C0014442#ent", "<e2>", "originally", "isolated", "from", "porcine", "pituitary", "anterior", "neurointermediate", "lobes", "."], "h": {"id": "C0063848", "name": "C0063848#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "soybean", "C0885100#ent", "<e1>", "performance", "is", "affected", "by", "C0042769#ent", "<e2>", "soybean", "plants"], "h": {"id": "C0885100", "name": "C0885100#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [12, 13]}}
{"token": ["The", "inhibitory", "effect", "of", "SeO2", "on", "C1259877#ent", "<e1>", "additive", "to", "that", "of", "another", "inhibitor", "of", "the", "C0014442#ent", "<e2>", "(", "alkyl-lysophospholipid", ")", "when", "present", "together", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [16, 17]}}
{"token": ["Using", "this", "model", "system", "we", "have", "shown", "that", "the", "effects", "of", "are", "transmitted", "by", "C1259877#ent", "<e1>", "abolished", "by", "downregulation", "of", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["Common", "causes", "of", "C0151434#ent", "<e1>", "C0263912#ent", "<e2>", "subluxation", "of", "the", "biceps", "tendon", "and", "attrition", "tendinitis", "whereas", "C0151434#ent", "<e1>", "secondary", "to", "bone", "neoplasm", "rare", "."], "h": {"id": "C0263912", "name": "C0263912#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0151434", "name": "C0151434#ent", "pos": [3, 4]}}
{"token": ["The", "C1334353#ent", "<e1>", "strain", "reverted", "in", "five", "generations", "to", "both", "cyromazine", "and", "C0961781#ent", "<e2>", "."], "h": {"id": "C1334353", "name": "C1334353#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0961781", "name": "C0961781#ent", "pos": [12, 13]}}
{"token": ["Baclofen-potentiated", "acid", "secretion", "evoked", "by", "bethanechol", "was", "partly", "prevented", "by", "bicuculline", "methiodide", "is", "a", "GABA(A)", "receptor", "antagonist", "but", "not", "by", "phaclofen", "which", "is", "a", "C2936801#ent", "<e1>", "suggesting", "an", "involvement", "of", "C1414919#ent", "<e2>"], "h": {"id": "C2936801", "name": "C2936801#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1414919", "name": "C1414919#ent", "pos": [30, 31]}}
{"token": ["X-linked", "polymorphic", "genetic", "markers", "were", "used", "in", "linkage", "studies", "these", "families", ",", "and", "the", "genes", "causing", "Dent's", "disease", "C0403720#ent", "<e1>", "were", "mapped", "to", "C1337030#ent", "<e2>", "."], "h": {"id": "C0403720", "name": "C0403720#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1337030", "name": "C1337030#ent", "pos": [23, 24]}}
{"token": ["As", "5-ASA", "has", "been", "shown", "to", "be", "the", "active", "therapeutic", "moiety", "sulphasalazine", ",", "C0353940#ent", "<e1>", "to", "be", "suitable", "for", "therapeutic", "trial", "C0009324#ent", "<e2>"], "h": {"id": "C0353940", "name": "C0353940#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0009324", "name": "C0009324#ent", "pos": [21, 22]}}
{"token": ["Rb+", "uptake", "through", "Rbo+/Ki+", "exchange", "contributes", "about", "25", "%", "to", "total", "Rb+", "uptake", "in", "145", "mM", "C1412125#ent", "<e1>", "media", "containing", "5", "mM", "RbCl", "at", "normal", "C1425360#ent", "<e2>", "(", "pH", "7.4", ")", "."], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1425360", "name": "C1425360#ent", "pos": [25, 26]}}
{"token": ["Hereditary", "diabetes", "insipidus", "occur", "in", "two", "forms", ":", "the", "first", ",", "referred", "to", "as", "C0011848#ent", "<e1>", "is", "responsive", "to", "vasopressin", "whereas", "the", "second", ",", "termed", "C1332124#ent", "<e2>", "is", "resistant", "to", "treatment", "."], "h": {"id": "C0011848", "name": "C0011848#ent", "pos": [14, 15]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332124", "name": "C1332124#ent", "pos": [25, 26]}}
{"token": ["Its", "expression", "in", "human", "liver", "is", "induced", "during", "C4288963#ent", "<e1>", "suggesting", "that", "C0050975#ent", "<e2>", "may", "play", "a", "role", "in", "the", "pathophysiology", "of", "this", "disease", "."], "h": {"id": "C4288963", "name": "C4288963#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0050975", "name": "C0050975#ent", "pos": [12, 13]}}
{"token": ["Accumulating", "evidence", "has", "indicated", "that", "gain-of-function", "in", "beta-amyloid", "production", "may", "be", "not", "the", "necessary", "mechanism", "for", "mutant", "presenilin-1", "PS1", ")", "or", "C2986919#ent", "<e1>", "to", "cause", "C0002395#ent", "<e2>", "AD", ")", "."], "h": {"id": "C2986919", "name": "C2986919#ent", "pos": [21, 22]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [25, 26]}}
{"token": ["These", "findings", "provide", "support", "for", "the", "hypothesis", "that", "C1705458#ent", "<e1>", "can", "serve", "as", "a", "scaffold", "for", "the", "C1709313#ent", "<e2>", "repression", "domain", "to", "access", "specific", "cellular", "gene", "promoters", "involved", "in", "growth", "regulation"], "h": {"id": "C1705458", "name": "C1705458#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [17, 18]}}
{"token": ["To", "better", "understand", "the", "role", "of", "these", "factors", "in", "bridging", "the", "C0105421#ent", "<e1>", "and", "CD40", "signaling", "pathways", "C0105421#ent", "<e1>", "signal", "regulation", "of", "C1538917#ent", "<e1>", "function", "was", "examined", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1538917", "name": "C1538917#ent", "pos": [22, 23]}}
{"token": ["This", "resulted", "in", "C0018133#ent", "<e1>", "aGVHD", ")", "and", "C0867389#ent", "<e2>", "cGVHD", ")", "in", "both", ",", "but", "they", "did", "not", "relapse", "."], "h": {"id": "C0018133", "name": "C0018133#ent", "pos": [3, 4]}, "relation": "nichd_parent_of", "t": {"id": "C0867389", "name": "C0867389#ent", "pos": [8, 9]}}
{"token": ["This", "paper", "reviews", "the", "history", "of", "C3536891#ent", "<e1>", "use", "in", "acne", ",", "including", "retinol", ",", "C3212626#ent", "<e2>", "topical", "and", "systemic", "isotretinoin", "systemic", "etretinate", "and", "new", "investigational", "retinoid", "molecules", "."], "h": {"id": "C3536891", "name": "C3536891#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3212626", "name": "C3212626#ent", "pos": [15, 16]}}
{"token": ["C3899313#ent", "<e1>", "was", "located", "between", "C1417546#ent", "<e2>", "muscle", "2", "MYL2", ")", "and", "D1Mgh11", "loci", "on", "Chr", "1", "and", "Ten-2", "was", "located", "between", "synaptotagmin", "II", "SYT2", ")", "and", "D13N2", "loci", "on", "Chr", "13"], "h": {"id": "C3899313", "name": "C3899313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417546", "name": "C1417546#ent", "pos": [5, 6]}}
{"token": ["Mutational", "inactivation", "tumor", "suppressor", "tuberous", "sclerosis", "complex", "2", "TSC2", ")", "in", "LAM", "C0907533#ent", "<e1>", "activates", "the", "mammalian", "target", "of", "rapamycin", "(mTOR)/p70", "C0073337#ent", "<e2>", "S6K1", ")", "signaling", "pathway", "promotes", "neoplastic", "growth", "LAM", "cells"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0073337", "name": "C0073337#ent", "pos": [21, 22]}}
{"token": ["To", "purify", "novel", "ligands", "for", "the", "corticotrophin-releasing", "factor", "binding", "protein", "C1413708#ent", "<e1>", ")", "from", "ovine", "brain", "whole", "brain", "homogenised", "in", "C0001962#ent", "<e2>", "and", "the", "supernatant", "extracted", "on", "Sep-pak", "C18", "cartridges", "followed", "by", "a", "preliminary", "HPLC", "step", "."], "h": {"id": "C1413708", "name": "C1413708#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [20, 21]}}
{"token": ["This", "case", "highlights", "the", "clinical", "course", "neonatal", "hypocalcemic", "seizures", "EEG", "findings", "in", "several", "cases", ",", "and", "possible", "mechanisms", "for", "both", "C0020598#ent", "<e1>", "precipitation", "of", "seizures", "and", "C0003286#ent", "<e2>", "ineffectiveness", "."], "h": {"id": "C0020598", "name": "C0020598#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [26, 27]}}
{"token": ["Furthermore", ",", "the", "translocation", "of", "C3540589#ent", "<e1>", "was", "regulated", "by", "C1366876#ent", "<e2>", "but", "not", "ERK", "or", "JNK", ",", "and", "the", "increase", "in", "endogenous", "N-SMase", "activity", "was", "abrogated", "by", "p38", "MAPK", "inhibition", "."], "h": {"id": "C3540589", "name": "C3540589#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366876", "name": "C1366876#ent", "pos": [10, 11]}}
{"token": ["The", "subjects", "of", "this", "study", "were", "14", "patients", "with", "C0042075#ent", "<e1>", "10", "patients", "with", "cerebral", "infarction", "4", "patients", "with", "other", "C0012634#ent", "<e2>", "."], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [20, 21]}}
{"token": ["Sub-inflammatory", "doses", "of", "C1417826#ent", "<e1>", "agonist", "still", "induced", "C0020429#ent", "<e2>", "and", "allodynia", "while", "C1417826#ent", "<e1>", "has", "been", "shown", "to", "be", "implicated", "in", "the", "generation", "of", "C0020429#ent", "<e2>", "in", "different", "inflammatory", "models"], "h": {"id": "C0020429", "name": "C0020429#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417826", "name": "C1417826#ent", "pos": [3, 4]}}
{"token": ["The", "NCC", "C3828360#ent", "<e1>", "PKC", "consisted", "of", "a", "60,000", "M(r", ")", "C0597298#ent", "<e2>", "and", "a", "30,000", "M(r", ")", "homologue", "equivalent", "to", "the", "mammalian", "PKC", "catalytic", "subunit"], "h": {"id": "C3828360", "name": "C3828360#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}}
{"token": ["C0812260#ent", "<e1>", "was", "localized", "to", "band", "10q11.2", "the", "subband", "where", "C1704885#ent", "<e2>", "also", "maps", ",", "at", "a", "minimum", "distance", "of", "more", "than", "500", "kb", "from", "the", "proto-oncogene", "."], "h": {"id": "C0812260", "name": "C0812260#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704885", "name": "C1704885#ent", "pos": [10, 11]}}
{"token": ["LPS", "was", "endocytosed", "by", "a", "receptor-mediated", "mechanism", "dependent", "on", "C1119970#ent", "<e1>", "and", "clathrin", "and", "colocalized", "with", "C1705581#ent", "<e2>", "on", "early/sorting", "endosomes", "."], "h": {"id": "C1119970", "name": "C1119970#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705581", "name": "C1705581#ent", "pos": [16, 17]}}
{"token": ["Alanine-scanning", "mutagenesis", "was", "used", "to", "examine", "the", "roles", "of", "residues", "surrounding", "serine", "293", "in", "catalysis", "by", "the", "C0030016#ent", "<e1>", "and", "in", "substrate", "recognition", "C1538319#ent", "<e2>"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1538319", "name": "C1538319#ent", "pos": [23, 24]}}
{"token": ["Subsequently", ",", "microsatellite", "markers", "used", "to", "assess", "linkage", "to", "the", "nonexcluded", "regions", "the", "genome", ",", "revealing", "tight", "linkage", "the", "locus", "of", "Col2a1", ",", "the", "C0079429#ent", "<e1>", "encoding", "the", "C1413580#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1413580", "name": "C1413580#ent", "pos": [28, 29]}}
{"token": ["This", "pericentromeric", "clustering", "of", "C2931498#ent", "<e1>", "families", "suggests", "allelism", ",", "with", "a", "minimum", "of", "2", "C1136249#ent", "<e2>", "XLMR", ")", "genes", "in", "this", "region", "."], "h": {"id": "C2931498", "name": "C2931498#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1136249", "name": "C1136249#ent", "pos": [15, 16]}}
{"token": ["All", "amino", "acids", "the", "LSQE", "sequence", "were", "critical", "for", "maximum", "C0030956#ent", "<e1>", "substrate", "suitability", "for", "C0919524#ent", "<e2>", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0919524", "name": "C0919524#ent", "pos": [15, 16]}}
{"token": ["The", "results", "indicate", "that", "capsaicin", "may", "activate", "the", "neurons", "of", "the", "brainstem", "nuclei", "in", "cardiovascular", "regulation", "C1519952#ent", "<e1>", "but", "does", "not", "exert", "any", "effects", "on", "C1705981#ent", "<e2>", "and", "RN", "."], "h": {"id": "C1519952", "name": "C1519952#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705981", "name": "C1705981#ent", "pos": [25, 26]}}
{"token": ["Similarly", ",", "pretreatment", "with", "R", "(+)-p-aminoglutethimide", "(", "C1412382#ent", "<e1>", ")", ",", "an", "inhibitor", "of", "C1413855#ent", "<e2>", "attenuated", "acute", "retinal", "cell", "damage"], "h": {"id": "C1412382", "name": "C1412382#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413855", "name": "C1413855#ent", "pos": [14, 15]}}
{"token": ["C4055175#ent", "<e1>", "induced", "cell", "cycle", "arrest", "reducing", "the", "expression", "of", "cyclin", "D1", "C0080054#ent", "<e2>", "and", "Cdc25C", "and", "apoptosis", "by", "reducing", "the", "expression", "of", "XIAP", "and", "survivin", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0080054", "name": "C0080054#ent", "pos": [12, 13]}}
{"token": ["Six", "additional", "C0015230#ent", "<e1>", "were", "shown", "to", "comprise", "proteins", "encoded", "by", "C0079941#ent", "<e2>", "have", "not", "been", "predicted", "for", "M.", "tuberculosis", "by", "genomic", "investigations"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [11, 12]}}
{"token": ["The", "mechanism", "of", "these", "effects", "was", "studied", "using", "doses", "of", "bradykinin", "or", "A23187", "which", "resulted", "in", "increases", "in", "Ca2", "+", "influx", "and", "C0072259#ent", "<e1>", "similar", "magnitude", "for", "each", "C0243192#ent", "<e2>", "."], "h": {"id": "C0072259", "name": "C0072259#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [28, 29]}}
{"token": ["These", "C0086376#ent", "<e1>", "probably", "correspond", "to", "cyclin", "A", "B", "and", "C0035547#ent", "<e2>"], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035547", "name": "C0035547#ent", "pos": [10, 11]}}
{"token": ["To", "assess", "whether", "C1419034#ent", "<e1>", "is", "directly", "linked", "to", "the", "pathogenesis", "of", "C3536715#ent", "<e2>", "we", "have", "developed", "a", "C1419034#ent", "<e1>", "transgenic", "mouse", "model", "."], "h": {"id": "C3536715", "name": "C3536715#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419034", "name": "C1419034#ent", "pos": [3, 4]}}
{"token": ["Treatment", "of", "C1705859#ent", "<e1>", "and", "ChIMP-a", "with", "C0114612#ent", "<e2>", "indicates", "that", "ChIMP-a", "is", "N-glycosylated", "whereas", "C1705859#ent", "<e1>", "is", "not", "."], "h": {"id": "C1705859", "name": "C1705859#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0114612", "name": "C0114612#ent", "pos": [7, 8]}}
{"token": ["This", "study", "examines", "the", "effect", "of", "C0724624#ent", "<e1>", "pneumotoxicity", "on", "C1422342#ent", "<e2>", "the", "rat", "diaphragm", "."], "h": {"id": "C0724624", "name": "C0724624#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1422342", "name": "C1422342#ent", "pos": [10, 11]}}
{"token": ["Expression", "of", "genes", "involved", "in", "C1333237#ent", "<e1>", "DNA", "synthesis", "including", "ribonucleotide", "reductase", "M1", "RRM1", ")", "and", "excision", "repair", "cross-complementation", "1", "C1333483#ent", "<e2>", ")", "has", "been", "reported", "to", "be", "associated", "with", "chemosensitivity", "to", "platinum", "agents", "gemcitabine", "."], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1333483", "name": "C1333483#ent", "pos": [20, 21]}}
{"token": ["We", "have", "studied", "the", "therapeutic", "effects", "ketanserin", ",", "a", "specific", "C0162757#ent", "<e1>", "on", "digital", "ischaemia", "11", "patients", "with", "the", "C0206138#ent", "<e2>", "systemic", "sclerosis"], "h": {"id": "C0162757", "name": "C0162757#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0206138", "name": "C0206138#ent", "pos": [19, 20]}}
{"token": ["The", "VHL", "protein", "shown", "to", "bind", "tightly", "and", "specifically", "to", "the", "Elongin", "B", "C0599220#ent", "<e1>", "to", "inhibit", "Elongin", "(", "C3890779#ent", "<e2>", ")", "transcriptional", "activity", "in", "vitro"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3890779", "name": "C3890779#ent", "pos": [19, 20]}}
{"token": ["VHL", "forms", "a", "multimeric", "complex", "two", "C0599220#ent", "<e1>", "(", "B", "and", "C", ")", "of", "the", "C3890779#ent", "<e2>", "(", "elongin", ")", "transcriptional", "elongation", "complex", "CUL2", ",", "a", "member", "of", "the", "cullin", "family"], "h": {"id": "C0599220", "name": "C0599220#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3890779", "name": "C3890779#ent", "pos": [15, 16]}}
{"token": ["Analysis", "of", "C1417244#ent", "<e1>", "leaf", "cross", "sections", "revealed", "that", "regardless", "of", "the", "light", "condition", "C3179066#ent", "<e2>", "are", "more", "evenly", "distributed", "in", "leaf", "mesophyll", "cells", "in", "the", "wild", "type"], "h": {"id": "C1417244", "name": "C1417244#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3179066", "name": "C3179066#ent", "pos": [14, 15]}}
{"token": ["C0243025#ent", "<e1>", "was", "likely", "induced", "by", "C0020740#ent", "<e2>", ",", "based", "on", "the", "presence", "of", "pancytopenia", "and", "a", "weakly", "positive", "drug", "lymphocyte", "stimulating", "test", "DLST", ")", "."], "h": {"id": "C0243025", "name": "C0243025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020740", "name": "C0020740#ent", "pos": [6, 7]}}
{"token": ["In", "a", "phase", "I", "trial", "several", "patients", "with", "AIPC", "had", "elevated", "serum", "C1418948#ent", "<e1>", "levels", "while", "receiving", "C0950779#ent", "<e2>", "that", "reversed", "upon", "discontinuation", "."], "h": {"id": "C1418948", "name": "C1418948#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0950779", "name": "C0950779#ent", "pos": [17, 18]}}
{"token": ["The", "cis-acting", "DNA", "elements", "in", "the", "5'-flanking", "region", "the", "AdoMet", "synthetase", "gene", "drive", "chloramphenicol", "C0001390#ent", "<e1>", "expression", "in", "mouse", "C0669372#ent", "<e2>", "were", "identified", "by", "transient", "expression", "assays"], "h": {"id": "C0001390", "name": "C0001390#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [19, 20]}}
{"token": ["Decreased", "activity", "of", "these", "C3540790#ent", "<e1>", "may", "cause", "many", "neurological", "syndromes", "such", "as", "C0085292#ent", "<e2>", "chronic", "fatigue", "syndrome", "anxiety", "disorders", "seizures", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085292", "name": "C0085292#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "PTEN-induced", "putative", "kinase", "1", "C0812377#ent", "<e1>", ")", "gene", "have", "been", "linked", "to", "an", "autosomal", "C0017361#ent", "<e2>", "familial", "Parkinson's", "disease"], "h": {"id": "C0812377", "name": "C0812377#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017361", "name": "C0017361#ent", "pos": [16, 17]}}
{"token": ["Ventricular", "fibrillation", "C0042510#ent", "<e1>", ")", "occurred", "only", "in", "the", "C0027051#ent", "<e2>", "group", "and", "appeared", "in", "9", "(", "5.66", "%", ")", "of", "these", "cases", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027051", "name": "C0027051#ent", "pos": [9, 10]}}
{"token": ["These", "data", "demonstrate", "that", "LPS", "treatment", ",", "in", "vivo", "in", "vitro", "induced", "C1522428#ent", "<e1>", "expression", "in", "TIMs", ",", "and", "that", "IL-1", "inhibits", "C1706114#ent", "<e2>", "mRNA", "in", "vitro"], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706114", "name": "C1706114#ent", "pos": [22, 23]}}
{"token": ["The", "same", "gene", "was", "subsequently", "found", "to", "be", "involved", "in", "C0271097#ent", "<e1>", "which", "features", "deafness", ",", "vestibular", "dysfunction", "and", "progressive", "C0220701#ent", "<e2>"], "h": {"id": "C0271097", "name": "C0271097#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0220701", "name": "C0220701#ent", "pos": [20, 21]}}
{"token": ["Although", "mouse", "platelets", "cause", "immune", "adherence", "hemagglutination", "with", "C3b-bearing", "C3891070#ent", "<e1>", ",", "they", "are", "C1413694#ent", "<e2>", "negative", "."], "h": {"id": "C3891070", "name": "C3891070#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413694", "name": "C1413694#ent", "pos": [14, 15]}}
{"token": ["Sarafotoxin", "S6C", "an", "ETB", "receptor", "C2987634#ent", "<e1>", ",", "also", "inhibited", "basal", "PRL", "release", ",", "whereas", "C0379142#ent", "<e2>", ",", "an", "ETA", "receptor", "antagonist", "had", "no", "effect", "on", "basal", "or", "on", "ET-1-mediated", "inhibition", "of", "PRL", "release", "."], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0379142", "name": "C0379142#ent", "pos": [15, 16]}}
{"token": ["Using", "various", "C2987634#ent", "<e1>", ",", "and", "the", "specific", "antagonist", "C0379142#ent", "<e2>", ",", "we", "have", "examined", "the", "sensitivity", "to", "endothelin", "of", "the", "vascular", "smooth", "muscle", "the", "ventral", "aorta", "the", "spiny", "dogfish", "shark", "Squalus", "acanthias"], "h": {"id": "C2987634", "name": "C2987634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0379142", "name": "C0379142#ent", "pos": [9, 10]}}
{"token": ["In", "contrast", ",", "C0162316#ent", "<e1>", "reversed", "at", "similar", "rates", "after", "intravenous", "treatment", "C0022092#ent", "<e2>", "control", "hematocrit", "values", "were", "reached", "after", "4", "and", "5", "days", "in", "the", "50-and", "100-day-old", "rats", ",", "respectively", "."], "h": {"id": "C0162316", "name": "C0162316#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0022092", "name": "C0022092#ent", "pos": [12, 13]}}
{"token": ["Famotidine", "and", "C0021246#ent", "<e1>", "pretreatment", "only", "partially", "counteracted", "the", "C3273545#ent", "<e2>", "effect", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3273545", "name": "C3273545#ent", "pos": [9, 10]}}
{"token": ["To", "study", "the", "effect", "of", "heparin", "on", "thrombin", "formation", "in", "vivo", "we", "measured", "thrombin-antithrombin", "III", "complexes", "C0017375#ent", "<e1>", ")", "in", "26", "patients", "treated", "with", "heparin", "for", "C1956346#ent", "<e2>", "deep", "vein", "thrombosis"], "h": {"id": "C0017375", "name": "C0017375#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [26, 27]}}
{"token": ["Phosphatidic", "acid", "PA", ")", "phosphatase", "2a", "C1335404#ent", "<e1>", ")", "is", "an", "C1427295#ent", "<e2>", "hydrolyzes", "a", "number", "of", "structurally", "related", "lipid", "phosphate", "substrates", "when", "presented", "in", "mixed", "phospholipid", "and", "detergent", "micelles", "."], "h": {"id": "C1335404", "name": "C1335404#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1427295", "name": "C1427295#ent", "pos": [11, 12]}}
{"token": ["Treatment", "of", "corneal", "infection", "antibiotics", "does", "not", "necessarily", "halt", "the", "process", "of", "C0010043#ent", "<e1>", "which", "is", "characterized", "by", "excessive", "degradation", "of", "C0009325#ent", "<e2>", "or", "resolve", "persistent", "corneal", "epithelial", "defects", "."], "h": {"id": "C0010043", "name": "C0010043#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [21, 22]}}
{"token": ["Exogenous", "C0010481#ent", "<e1>", "CS", ")", "in", "HIV-infected", "patients", "receiving", "ritonavir", "and", "C0082607#ent", "<e2>", "has", "been", "reported", "frequently", "in", "adults", "but", "not", "in", "children", "."], "h": {"id": "C0010481", "name": "C0010481#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0082607", "name": "C0082607#ent", "pos": [11, 12]}}
{"token": ["Transgenic", "(", "C0039902#ent", "<e1>", ")", "mice", "overexpressing", "rat", "C1527149#ent", "<e2>", "hsp70", ")", "demonstrated", "less", "infarction", "than", "did", "wild-type", "(", "WT", ")", "littermates", "after", "permanent", "focal", "cerebral", "ischemia"], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1527149", "name": "C1527149#ent", "pos": [8, 9]}}
{"token": ["C1413193#ent", "<e1>", "and", "CKI", "C0017337#ent", "<e2>", "on", "pCKG55", "were", "designed", "to", "be", "expressed", "as", "a", "single", "CCT/CKI", "fused", "protein", "."], "h": {"id": "C1413193", "name": "C1413193#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}}
{"token": ["Type", "2", "diabetes", "associated", "with", "obesity", ",", "insulin", "resistance", "hyperglycemia", ",", "hyperphagia", ",", "polyuria", ",", "body", "weight", "gain", "excessive", "secretion", "of", "glucocorticoids", "(", "C1704697#ent", "<e1>", ")", ",", "thymus", "involution", ",", "adrenal", "gland", "hypertrophy", "C1442864#ent", "<e2>", "etc", "."], "h": {"id": "C1704697", "name": "C1704697#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [33, 34]}}
{"token": ["Our", "findings", "indicate", "that", "C1522670#ent", "<e1>", "treatment", "may", "be", "of", "value", "in", "C0948008#ent", "<e2>"], "h": {"id": "C1522670", "name": "C1522670#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0948008", "name": "C0948008#ent", "pos": [12, 13]}}
{"token": ["C1421469#ent", "<e1>", "is", "expressed", "at", "lower", "levels", "than", "VRK1", "and", "C1425940#ent", "<e2>", "in", "the", "mouse", "embryo"], "h": {"id": "C1421469", "name": "C1421469#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1425940", "name": "C1425940#ent", "pos": [10, 11]}}
{"token": ["Consistent", "with", "findings", ",", "C0769198#ent", "<e1>", "led", "to", "increased", "BSEP", "promoter", "activity", "an", "intact", "C1417825#ent", "<e2>", "regulatory", "element", ",", "whereas", "C0769198#ent", "<e1>", "failed", "to", "transactivate", "the", "BSEP", "promoter", "with", "a", "mutated", "FXRE", "."], "h": {"id": "C0769198", "name": "C0769198#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417825", "name": "C1417825#ent", "pos": [14, 15]}}
{"token": ["It", "has", "been", "suggested", "that", "both", "C0030805#ent", "<e1>", "BP", ")", "and", "C0011633#ent", "<e2>", "are", "associated", "with", "internal", "malignancies"], "h": {"id": "C0030805", "name": "C0030805#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011633", "name": "C0011633#ent", "pos": [11, 12]}}
{"token": ["Sequence", "comparison", "of", "gapC", "with", "related", "C0017337#ent", "<e1>", "suggests", "its", "acquisition", "by", "horizontal", "gene", "transfer", "C0085426#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0085426", "name": "C0085426#ent", "pos": [15, 16]}}
{"token": ["C0027697#ent", "<e1>", "developed", "in", "81", "of", "278", "patients", "with", "C2721603#ent", "<e2>", "29", "%", ")", "."], "h": {"id": "C0027697", "name": "C0027697#ent", "pos": [0, 1]}, "relation": "nichd_parent_of", "t": {"id": "C2721603", "name": "C2721603#ent", "pos": [9, 10]}}
{"token": ["However", ",", "flat", "revertants", "retransformed", "by", "5-azacytidine", ",", "without", "concomitant", "reactivation", "of", "C1709313#ent", "<e1>", ",", "were", "resistant", "to", "C1710304#ent", "<e2>", "."], "h": {"id": "C1709313", "name": "C1709313#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [18, 19]}}
{"token": ["Nucleotide", "sequence", "analysis", "that", "the", "cDNA", "clone", "21", "carries", "a", "mitochondrial", "sequence", "to", "the", "3", "'", "portion", "of", "the", "C1335641#ent", "<e1>", "by", "the", "5", "'", "portion", "of", "the", "C1335643#ent", "<e2>"], "h": {"id": "C1335641", "name": "C1335641#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1335643", "name": "C1335643#ent", "pos": [28, 29]}}
{"token": ["These", "include", "interactions", "between", "the", "C1335439#ent", "<e1>", "and", "the", "helicase", ",", "the", "helicase", "and", "the", "C1335494#ent", "<e2>", ",", "and", "the", "C1335494#ent", "<e2>", "and", "the", "C1335439#ent", "<e1>", "."], "h": {"id": "C1335439", "name": "C1335439#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1335494", "name": "C1335494#ent", "pos": [15, 16]}}
{"token": ["C0267963#ent", "<e1>", "with", "hepatitis", "B", "surface", "antigen", "HBsAg", ")", "and", "a", "synthetic", "peptide", "C1979730#ent", "<e2>", "NP", "peptide", "elicited", "antigen-specific", "CTL", "responses", "as", "well", "as", "antibody", "responses"], "h": {"id": "C0267963", "name": "C0267963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1979730", "name": "C1979730#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "our", "experience", "with", "3", "cases", "and", "a", "literature", "review", "whether", "C0723402#ent", "<e1>", "an", "early", "manifestation", "adult", "C0087031#ent", "<e2>", "AOSD", ")", "."], "h": {"id": "C0723402", "name": "C0723402#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0087031", "name": "C0087031#ent", "pos": [18, 19]}}
{"token": ["Furthermore", ",", "we", "found", "that", "mitogen", "induction", "of", "the", "C1705786#ent", "<e1>", ")", "gene", ",", "a", "mammalian", "C1334043#ent", "<e2>", "of", "the", "Caenorhabditis", "elegans", "cell", "death", "ced-3", ",", "is", "also", "IRF-1-dependent", "."], "h": {"id": "C1705786", "name": "C1705786#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [16, 17]}}
{"token": ["These", "data", "document", "a", "mechanism", "of", "action", "of", "the", "C3887659#ent", "<e1>", "inhibitors", "independent", "of", "deoxyguanosine", "and", "partially", "reversible", "by", "C0879590#ent", "<e2>", "."], "h": {"id": "C3887659", "name": "C3887659#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [19, 20]}}
{"token": ["The", "extent", "of", "ATP", "release", "decreased", "in", "parallel", "with", "the", "decrease", "in", "activation", "ratio", "calpain", "I", "treatment", "of", "platelets", "with", "EGTA", "or", "C1420459#ent", "<e1>", ",", "a", "membrane-permeable", "inhibitor", "of", "C0006784#ent", "<e2>", "."], "h": {"id": "C1420459", "name": "C1420459#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [29, 30]}}
{"token": ["Indeed", ",", "C1334294#ent", "<e1>", "expression", "correlates", "with", "cancer", "malignancy", "clinical", "studies", "that", "C3536711#ent", "<e2>", "treatment", "is", "beneficial", "in", "cancer", "patients", "."], "h": {"id": "C1334294", "name": "C1334294#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [12, 13]}}
{"token": ["These", "effects", "were", "inhibited", "by", "the", "C0038766#ent", "<e1>", ",", "glibenclamide", "and", "C0040374#ent", "<e2>", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [6, 7]}, "relation": "structural_class_of", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [11, 12]}}
{"token": ["C0038766#ent", "<e1>", "e.g.", ",", "glibenclamide", ",", "glipizide", ",", "and", "C0040374#ent", "<e2>", ")", "exert", "their", "stimulatory", "effect", "on", "excitatory", "cells", "by", "closure", "of", "ATP-sensitive", "potassium", "KATP", ")", "channels", "."], "h": {"id": "C0038766", "name": "C0038766#ent", "pos": [0, 1]}, "relation": "structural_class_of", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [9, 10]}}
{"token": ["This", "study", "was", "undertaken", "to", "determine", "whether", "there", "is", "any", "association", "between", "C1704264#ent", "<e1>", "polymorphism", "and", "C0162309#ent", "<e2>", "in", "a", "Chinese", "population"], "h": {"id": "C1704264", "name": "C1704264#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0162309", "name": "C0162309#ent", "pos": [16, 17]}}
{"token": ["We", "found", "that", "human", "fetal", "astrocytes", "(", "C0015458#ent", "<e1>", ")", "are", "able", "to", "support", "superantigen", "(", "C1419805#ent", "<e2>", ")", "staphylococcal", "enterotoxin", "B", "SEB", ")", "and", "toxic", "shock", "syndrome", "toxin-1", "activation", "of", "immediately", "ex", "vivo", "allogenic", "human", "CD4", "T", "cells"], "h": {"id": "C0015458", "name": "C0015458#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1419805", "name": "C1419805#ent", "pos": [16, 17]}}
{"token": ["Neither", "ANP", "nor", "C0282211#ent", "<e1>", "inhibited", "the", "arachidonic", "acid-induced", "in", "C1167782#ent", "<e2>"], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1167782", "name": "C1167782#ent", "pos": [10, 11]}}
{"token": ["Relative", "potency", "varied", "with", "assay", "type", "but", "C1880218#ent", "<e1>", "and", "l-centchroman", ",", "surprisingly", ",", "inhibited", "both", "C0379099#ent", "<e2>", "and", "phosphodiesterase", "activity", "similar", "concentrations", "."], "h": {"id": "C1880218", "name": "C1880218#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0379099", "name": "C0379099#ent", "pos": [16, 17]}}
{"token": ["TPA", "(", "0.3", "microM", ")", "blocked", "the", "maximal", "response", "to", "C0282211#ent", "<e1>", "but", "not", "to", "C0037533#ent", "<e2>", "that", "TPA", "did", "selectively", "activate", "protein", "kinase", "C", "these", "experimental", "conditions"], "h": {"id": "C0282211", "name": "C0282211#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037533", "name": "C0037533#ent", "pos": [15, 16]}}
{"token": ["To", "characterize", "C0240940#ent", "<e1>", "involvement", "in", "patients", "with", "C0221056#ent", "<e2>", "."], "h": {"id": "C0240940", "name": "C0240940#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221056", "name": "C0221056#ent", "pos": [8, 9]}}
{"token": ["Various", "C0037284#ent", "<e1>", "including", "multiple", "nevi", "skin", "tags", "hemangiomas", ",", "one", "C0017547#ent", "<e2>", "melanotic", "nevus", "and", "a", "history", "of", "a", "previously", "removed", "angiosarcoma", ")", "were", "present", "in", "8/40", "(", "20", "%", ")", "."], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017547", "name": "C0017547#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "these", "drugs", "were", "found", "to", "enhance", "MMP", "secretion", "from", "MEC", ",", "although", "the", "activity", "of", "the", "secreted", "C3494976#ent", "<e1>", "was", "inhibited", "as", "long", "as", "the", "C1254351#ent", "<e2>", "was", "present", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [27, 28]}}
{"token": ["A", "21-year-old", "female", "developed", "purplish-red", "round", "eruptions", "on", "her", "neck", "and", "left", "thigh", "taking", "an", "analgesic", "containing", "isopropylantipyrine", ",", "C0052234#ent", "<e1>", ",", "phenacetin", "and", "C1170114#ent", "<e2>"], "h": {"id": "C0052234", "name": "C0052234#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1170114", "name": "C1170114#ent", "pos": [24, 25]}}
{"token": ["C0013765#ent", "<e1>", "is", "an", "C1333497#ent", "<e2>", "imparts", "elasticity", "to", "tissues", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333497", "name": "C1333497#ent", "pos": [4, 5]}}
{"token": ["The", "indications", "for", "antibiotic", "treatment", "bronchopulmonary", "infections", "peritonitis", ",", "C0149778#ent", "<e1>", "biliary", "and", "urinary", "tract", "infections", "postoperative", "C0009952#ent", "<e2>", "conditions", "of", "unknown", "origin", "."], "h": {"id": "C0149778", "name": "C0149778#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0009952", "name": "C0009952#ent", "pos": [17, 18]}}
{"token": ["The", "mean", "gestational", "age", "delivery", "was", "significantly", "higher", "for", "C0164398#ent", "<e1>", "compared", "with", "C0035661#ent", "<e2>", "(", "36", "vs", "33", "weeks", ";", "p", "<", "0.001", ")", "."], "h": {"id": "C0164398", "name": "C0164398#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035661", "name": "C0035661#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "mutant", "C1705316#ent", "<e1>", "compromised", "telomerase", "activity", "by", "C2987364#ent", "<e2>", "C1705316#ent", "<e1>", "in", "a", "manner", "directly", "attributable", "to", "mutant", "C1705316#ent", "<e1>", "expression", "level", "."], "h": {"id": "C1705316", "name": "C1705316#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}}
{"token": ["The", "vacuolar", "aspartyl", "protease", "proteinase", "A", "C3274822#ent", "<e1>", ")", "of", "Saccharomyces", "cerevisiae", "encoded", "as", "a", "preproenzyme", "by", "the", "C1419064#ent", "<e2>", "transported", "to", "the", "vacuole", "via", "the", "secretory", "route"], "h": {"id": "C3274822", "name": "C3274822#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419064", "name": "C1419064#ent", "pos": [18, 19]}}
{"token": ["C0664750#ent", "<e1>", "downregulates", "the", "expression", "of", "NPM", ",", "Nup88", "and", "C1704852#ent", "<e2>", "in", "a", "dose-dependent", "manner", "and", "reverts", "the", "localization", "of", "Nup88", "and", "C1704852#ent", "<e2>", "to", "nuclear", "rim"], "h": {"id": "C0664750", "name": "C0664750#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704852", "name": "C1704852#ent", "pos": [10, 11]}}
{"token": ["C0376175#ent", "<e1>", "to", "cat", "scratch", "disease", "C1425926#ent", "<e2>", ")", "has", "not", "been", "described", "previously", "."], "h": {"id": "C0376175", "name": "C0376175#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1425926", "name": "C1425926#ent", "pos": [6, 7]}}
{"token": ["We", "conducted", "a", "double-blind", "study", "66", "women", "with", "C0029458#ent", "<e1>", "therapy", "with", "C0037507#ent", "<e2>", ",", "a", "diphosphonate", "compound", "reduces", "bone", "resorption", "inhibiting", "osteoclastic", "activity"], "h": {"id": "C0029458", "name": "C0029458#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0037507", "name": "C0037507#ent", "pos": [12, 13]}}
{"token": ["The", "murine", "model", "of", "haematogenously", "acquired", "C0003869#ent", "<e1>", "used", ",", "injecting", "intravenously", "C0600327#ent", "<e2>", "TSST-1", ")", ",", "producing", "S.", "aureus", "."], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0600327", "name": "C0600327#ent", "pos": [12, 13]}}
{"token": ["Using", "selective", "agonists", "and", "antagonists", "of", "alpha1", "and", "alpha2", "adrenergic", "receptors", "ARs", ")", ",", "we", "show", "that", "C1705443#ent", "<e1>", "neurons", "have", "functional", "alpha1-", "and", "C3811649#ent", "<e2>", "controlling", "C1705443#ent", "<e1>", "firing", "with", "an", "impact", "on", "locomotor", "activity"], "h": {"id": "C1705443", "name": "C1705443#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3811649", "name": "C3811649#ent", "pos": [24, 25]}}
{"token": ["C3541394#ent", "<e1>", "can", "cause", "C0155877#ent", "<e2>", "rhinitis", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0155877", "name": "C0155877#ent", "pos": [4, 5]}}
{"token": ["Our", "model", "provides", "a", "useful", "tool", "for", "studying", "hPXR", "activation", "and", "for", "identifying", "C0035064#ent", "<e1>", "capable", "of", "inducing", "CYP3A4", "and", "C1828468#ent", "<e2>", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1828468", "name": "C1828468#ent", "pos": [20, 21]}}
{"token": ["C0076316#ent", "<e1>", "also", "inhibits", "C3887648#ent", "<e2>", "(NE)-induced", "vasocontraction", "in", "the", "presence", "of", "extracellular", "Ca++", "."], "h": {"id": "C0076316", "name": "C0076316#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887648", "name": "C3887648#ent", "pos": [4, 5]}}
{"token": ["A", "kinase-encoding", "C0971285#ent", "<e1>", "is", "located", "in", "20q13", "and", "recently", "a", "Phe31Ile", "(", "91", "T", ">", "A", ")", "change", "of", "C0971285#ent", "<e1>", "was", "suggested", "to", "function", "as", "a", "low", "penetrance", "C1336678#ent", "<e1>"], "h": {"id": "C0971285", "name": "C0971285#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1336678", "name": "C1336678#ent", "pos": [30, 31]}}
{"token": ["To", "investigate", "the", "effects", "of", "C0066677#ent", "<e1>", "on", "regional", "cerebral", "blood", "flow", "rCBF", ")", "in", "C0027404#ent", "<e2>", ",", "we", "performed", "99mTc-ethylcysteinate", "dimer", "single", "photon", "emission", "computed", "tomography", "SPECT", ")", "before", "and", "after", "C0066677#ent", "<e1>", "or", "placebo", "medication", "."], "h": {"id": "C0066677", "name": "C0066677#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0027404", "name": "C0027404#ent", "pos": [15, 16]}}
{"token": ["Transient", "neurological", "symptoms", "in", "12", "patients", "(", "39", "%", ")", ",", "including", "dizziness", "or", "C0012833#ent", "<e1>", ",", "marked", "fatigue", ",", "visual", "blurring", "C0004134#ent", "<e2>", ",", "paresthesia", ",", "and", "nausea", "."], "h": {"id": "C0012833", "name": "C0012833#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [22, 23]}}
{"token": ["C0038742#ent", "<e1>", "normalises", "the", "shortened", "platelet", "survival", "associated", "with", "C0018099#ent", "<e2>", "or", "artificial", "heart", "valves", "has", "shown", "benefit", "in", "secondary", "prevention", "myocardial", "infarction"], "h": {"id": "C0038742", "name": "C0038742#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [9, 10]}}
{"token": ["The", "ability", "of", "two", "C0003211#ent", "<e1>", "piroxicam", "and", "C0012091#ent", "<e2>", "--", "to", "control", "endodontic", "pain", "compared", "with", "that", "of", "a", "placebo", "control", "in", "a", "double-blind", "study", "267", "patients", "requiring", "endodontic", "therapy", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [4, 5]}, "relation": "structural_class_of", "t": {"id": "C0012091", "name": "C0012091#ent", "pos": [8, 9]}}
{"token": ["These", "data", "suggest", "that", "endogenous", "C3273437#ent", "<e1>", "plays", "an", "important", "role", "in", "C1171556#ent", "<e2>", "airway", "constriction", "in", "guinea", "pigs", "."], "h": {"id": "C3273437", "name": "C3273437#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1171556", "name": "C1171556#ent", "pos": [12, 13]}}
{"token": ["Whilst", "the", "numerical", "density", "of", "Schwann", "cells", "not", "change", "with", "disease", ",", "fewer", "varicosities", "were", "identified", "within", "Schwann", "cells", "motor", "neurone", "disease", "C0270984#ent", "<e1>", "neuropathy", "and", "C0026848#ent", "<e2>", "due", "to", "toxins", "or", "vascular", "disease"], "h": {"id": "C0270984", "name": "C0270984#ent", "pos": [22, 23]}, "relation": "has_nichd_parent", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [26, 27]}}
{"token": ["We", "suggest", "that", "C1416661#ent", "<e1>", ",", "Erbin", ",", "and", "TCFL5", "are", "essential", "for", "C3890389#ent", "<e2>", "formation", "and", "play", "a", "key", "role", "in", "the", "development", "of", "tumor", "diseases"], "h": {"id": "C1416661", "name": "C1416661#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3890389", "name": "C3890389#ent", "pos": [13, 14]}}
{"token": ["Venlafaxine", ",", "aripiprazole", ",", "C0245561#ent", "<e1>", ",", "and", "atomoxetine", "are", "newer", "drugs", "C0025517#ent", "<e2>", "by", "CYP2D6", "but", "studies", "of", "the", "clinical", "relevance", "of", "CYP2D6", "genotypes", "are", "needed", "."], "h": {"id": "C0245561", "name": "C0245561#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [12, 13]}}
{"token": ["In", "double", "immunofluorescent", "staining", "experiments", ",", "many", "cells", "expressed", "both", "N-CAM", "and", "C0080059#ent", "<e1>", "shortly", "after", "C0042769#ent", "<e2>", "which", "implies", "that", "the", "N-CAM-positive", "neuroepithelial", "cells", "transformed", "by", "RSV", "."], "h": {"id": "C0080059", "name": "C0080059#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [16, 17]}}
{"token": ["We", "demonstrate", "that", "cGK", "phosphorylates", "C0084340#ent", "<e1>", "in", "vitro", "Ser188", ",", "the", "same", "residue", "phosphorylated", "by", "C1514550#ent", "<e2>"], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1514550", "name": "C1514550#ent", "pos": [16, 17]}}
{"token": ["This", "mutation", "is", "located", "in", "the", "second", "extracellular", "loop", "the", "C1414828#ent", "<e1>", "within", "a", "motif", "highly", "conserved", "in", "C3536870#ent", "<e2>", "and", "TSH", "receptors"], "h": {"id": "C1414828", "name": "C1414828#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536870", "name": "C3536870#ent", "pos": [18, 19]}}
{"token": ["However", ",", "further", "addition", "of", "higher", "concentrations", "of", "the", "extract", "produced", "a", "marked", "inhibition", "of", "the", "C1537503#ent", "<e1>", "stimulation", "of", "C0031640#ent", "<e2>", "in", "13", "of", "15", "specimens", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0031640", "name": "C0031640#ent", "pos": [20, 21]}}
{"token": ["These", "data", "suggest", "that", "C1419304#ent", "<e1>", "comprises", "an", "important", "target", "for", "C1831954#ent", "<e2>", "cellular", "cytotoxicity"], "h": {"id": "C1419304", "name": "C1419304#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1831954", "name": "C1831954#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "effects", "of", "PGE2", ",", "a", "principal", "downstream", "prostaglandin", "product", "of", "C1705323#ent", "<e1>", "activity", ",", "on", "motor", "neuron", "survival", "in", "an", "organotypic", "culture", "model", "C1704945#ent", "<e2>", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [26, 27]}}
{"token": ["C1705323#ent", "<e1>", "expression", "was", "dramatically", "increased", "in", "the", "spinal", "cord", "patients", "with", "C1704945#ent", "<e2>", "."], "h": {"id": "C1705323", "name": "C1705323#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [12, 13]}}
{"token": ["HCA-7", ",", "a", "human", "colorectal", "adenocarcinoma", "cell", "line", "displays", "C1565860#ent", "<e1>", "and", "PGE2-dependent", "proliferation", ",", "expressed", "both", "COX-2", "and", "C3538682#ent", "<e2>", "constitutively", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3538682", "name": "C3538682#ent", "pos": [19, 20]}}
{"token": ["The", "sulfamoyl", "group", "on", "zonisamide", "was", "expected", "to", "suppress", "C0036572#ent", "<e1>", "in", "a", "manner", "similar", "to", "another", "sulfonamide", "analogue", "C0000981#ent", "<e2>", ",", "through", "inhibition", "of", "carbonic", "anhydrase"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}, "relation": "may_be_treated_by", "t": {"id": "C0000981", "name": "C0000981#ent", "pos": [19, 20]}}
{"token": ["Overall", ",", "Siglec-9", "is", "approximately", "80", "%", "identical", "in", "amino", "acid", "sequence", "C1420062#ent", "<e1>", ",", "suggesting", "that", "the", "C1417679#ent", "<e2>", "encoding", "these", "two", "proteins", "arose", "relatively", "recently", "by", "gene", "duplication"], "h": {"id": "C1420062", "name": "C1420062#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["For", "this", "reason", ",", "we", "used", "electron", "microscopic", "immunocytochemistry", "determine", "the", "subcellular", "localization", "the", "dopamine", "storage", "vesicles", "identified", "by", "the", "presence", "of", "C1420115#ent", "<e1>", ")", "in", "relation", "to", "the", "C1707622#ent", "<e2>", "in", "these", "VTA", "subdivisions", "."], "h": {"id": "C1420115", "name": "C1420115#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1707622", "name": "C1707622#ent", "pos": [29, 30]}}
{"token": ["GST-LANA(1", "-", "340", ")", "was", "phosphorylated", "by", "C4283740#ent", "<e1>", ",", "and", "mitogen-activated", "protein", "kinase", "MAPK", ")", "and", "casein", "kinase", "I", "as", "C0031727#ent", "<e2>", "in", "vitro"], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [21, 22]}}
{"token": ["After", "a", "14-", "to", "30-day", "recovery", "period", ",", "each", "animal", "was", "anesthetized", "with", "C0700349#ent", "<e1>", "estimated", "blood", "volume", "volume-expanded", "20", "%", "with", "6", "%", "C0011806#ent", "<e2>", "in", "isotonic", "saline"], "h": {"id": "C0700349", "name": "C0700349#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0011806", "name": "C0011806#ent", "pos": [24, 25]}}
{"token": ["Three", "had", "idiopathic", "pulmonary", "fibrosis", "2", "had", "pulmonary", "emphysema", "1", "had", "C0006274#ent", "<e1>", "and", "the", "other", "had", "a", "sequelae", "of", "C0041327#ent", "<e2>"], "h": {"id": "C0006274", "name": "C0006274#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "case", "of", "C0041296#ent", "<e1>", "treated", "with", "rifampin", ",", "isoniazid", "and", "C0034239#ent", "<e2>", "."], "h": {"id": "C0041296", "name": "C0041296#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0034239", "name": "C0034239#ent", "pos": [13, 14]}}
{"token": ["Disruption", "of", "caveolae", "with", "methyl-beta-cyclodextrin", "(", "C0285590#ent", "<e1>", ")", "resulted", "in", "(mis)sorting", "of", "C3540050#ent", "<e2>", "to", "the", "basolateral", "membrane"], "h": {"id": "C0285590", "name": "C0285590#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540050", "name": "C3540050#ent", "pos": [13, 14]}}
{"token": ["C0026056#ent", "<e1>", "is", "a", "water", "soluble", "C0005064#ent", "<e2>", ",", "with", "a", "short", "elimination", "half-life", "in", "adults", "and", "children", "."], "h": {"id": "C0026056", "name": "C0026056#ent", "pos": [0, 1]}, "relation": "has_chemical_structure", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [6, 7]}}
{"token": ["Orbach", "described", "an", "air", "block", "technique", "froth", "in", "1944", "and", "in", "1993", "Cabrera", "proposed", "use", "of", "a", "true", "foam", "of", "C0037556#ent", "<e1>", "polidocanol", "to", "treat", "C0042345#ent", "<e2>"], "h": {"id": "C0037556", "name": "C0037556#ent", "pos": [20, 21]}, "relation": "may_treat", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [25, 26]}}
{"token": ["This", "study", "assessed", "the", "C0728960#ent", "<e1>", "tramadol", "compared", "with", "placebo", "in", "patients", "suffering", "from", "C0016053#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016053", "name": "C0016053#ent", "pos": [14, 15]}}
{"token": ["Our", "program", "was", "tested", "on", "the", "fold", "recognition", "targets", "from", "C1413132#ent", "<e1>", "with", "known", "PDB", "codes", "and", "some", "available", "targets", "from", "C1437927#ent", "<e2>", "."], "h": {"id": "C1413132", "name": "C1413132#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1437927", "name": "C1437927#ent", "pos": [21, 22]}}
{"token": ["Here", "we", "demonstrate", "that", "induction", "of", "VMAT2", "and", "DAT", "specifically", "in", "mesDA", "neurons", "requires", "C2983693#ent", "<e1>", "expression", ",", "whereas", "C4042618#ent", "<e2>", "expression", "in", "mesDA", "neurons", "is", "induced", "independently", "of", "C2983693#ent", "<e1>", "function", "."], "h": {"id": "C4042618", "name": "C4042618#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2983693", "name": "C2983693#ent", "pos": [14, 15]}}
{"token": ["Lower", "inhibition", "was", "detected", "for", "1'-hydroxylation", "of", "bufurarol", ",", "21-hydroxylation", "of", "progesterone", "and", "6-hydroxylation", "of", "C0008296#ent", "<e1>", "catalyzed", "by", "CYP2D", ",", "C1378702#ent", "<e2>", "and", "CYP2E1", ",", "respectively", "."], "h": {"id": "C0008296", "name": "C0008296#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1378702", "name": "C1378702#ent", "pos": [21, 22]}}
{"token": ["The", "decrease", "in", "tumor-derived", "C1332691#ent", "<e1>", "also", "correlated", "with", "decreased", "C1332807#ent", "<e2>", "MMP-2", ",", "MMP-3", ",", "MMP-10", "and", "MMP-17", "gene", "expression", "."], "h": {"id": "C1332691", "name": "C1332691#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [10, 11]}}
{"token": ["Choline", "acetyltransferase", "in", "the", "brain", "remained", "unchanged", "during", "both", "C0042769#ent", "<e1>", "suggesting", "that", "the", "decrease", "in", "C1332390#ent", "<e2>", "activity", "does", "not", "reflect", "a", "generalized", "neuronal", "loss", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332390", "name": "C1332390#ent", "pos": [16, 17]}}
{"token": ["The", "results", "indicated", "that", "besides", "testosterone", "other", "C0949635#ent", "<e1>", "be", "involved", "in", "the", "development", "of", "C0178664#ent", "<e2>", "in", "male", "Imai", "rats", "."], "h": {"id": "C0949635", "name": "C0949635#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [15, 16]}}
{"token": ["The", "C0003211#ent", "<e1>", "studied", "included", "C0040377#ent", "<e2>", ",", "indomethacin", ",", "naproxen", ",", "and", "aspirin", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [1, 2]}, "relation": "structural_class_of", "t": {"id": "C0040377", "name": "C0040377#ent", "pos": [5, 6]}}
{"token": ["We", "now", "identify", "a", "novel", "repressive", "element", "from", "the", "C1414967#ent", "<e1>", "GAP-43", ")", "gene", "that", "can", "contribute", "to", "C1880904#ent", "<e2>", "gene", "expression", "inhibiting", "transcription", "in", "a", "wide", "range", "of", "non-neuronal", "cell", "types"], "h": {"id": "C1414967", "name": "C1414967#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [18, 19]}}
{"token": ["The", "C0235394#ent", "<e1>", "mouse", ",", "an", "animal", "model", "for", "the", "genetically", "transmitted", "C0004135#ent", "<e2>", "AT", ")", ",", "was", "examined", "for", "its", "biological", ",", "cytogenetic", "and", "biochemical", "properties"], "h": {"id": "C0235394", "name": "C0235394#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0004135", "name": "C0004135#ent", "pos": [12, 13]}}
{"token": ["Despite", "the", "high", "prevalence", "C0020676#ent", "<e1>", "patients", "with", "C2316401#ent", "<e2>", "little", "is", "known", "about", "the", "clinical", "features", "and", "implications", "of", "this", "disorder", "in", "end-stage", "renal", "disease", "patients", "."], "h": {"id": "C0020676", "name": "C0020676#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2316401", "name": "C2316401#ent", "pos": [8, 9]}}
{"token": ["Tissue-type", "plasminogen", "activator", "C1417510#ent", "<e1>", "MxB", ")", ",", "an", "C1420459#ent", "<e2>", "similar", "to", "galectin-1", ",", "follistatin", ",", "fatty", "acid-binding", "protein", "5", "C1420459#ent", "<e2>", "AA609749", ",", "annexin", "I", "the", "interferon-inducible", "gene", "1", "8U", ",", "and", "phospholipase", "D1", "highly", "overexpressed", "in", "androgen-independent", "LNCaP", "cells"], "h": {"id": "C1417510", "name": "C1417510#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420459", "name": "C1420459#ent", "pos": [9, 10]}}
{"token": ["Substance", "P", "C1420563#ent", "<e1>", "NK-1", ")", "receptors", "and", "C1537501#ent", "<e2>", "via", "B2", "receptors", "described", "to", "play", "important", "roles", "in", "the", "pathophysiology", "of", "acute", "pancreatitis"], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [8, 9]}}
{"token": ["C-fiber-independent", "extravasation", "also", "developed", "in", "this", "tissue", "after", "intravenous", "injections", "substance", "P", "C1420563#ent", "<e1>", "two", "constituents", "of", "unmyelinated", "C", "fibers", "and", "after", "serotonin", ",", "C1537501#ent", "<e2>", ",", "or", "allergic", "challenge", "in", "presensitized", "animals", "."], "h": {"id": "C1420563", "name": "C1420563#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1537501", "name": "C1537501#ent", "pos": [24, 25]}}
{"token": ["Although", "the", "expression", "of", "PDGF-alpha", "R", "been", "found", "to", "accompany", "that", "of", "C0210108#ent", "<e1>", ",", "its", "actual", "relevance", "for", "the", "development", "of", "the", "C0268731#ent", "<e2>", "not", "clear", "."], "h": {"id": "C0210108", "name": "C0210108#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [23, 24]}}
{"token": ["median", "convulsant", "dose", "C1334076#ent", "<e1>", ")", "of", "lidocaine", "and", "C0033216#ent", "<e2>", "with", "saline", "pre-treatment", "was", "95", "and", "240", "mg/kg", ",", "respectively", "."], "h": {"id": "C1334076", "name": "C1334076#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033216", "name": "C0033216#ent", "pos": [9, 10]}}
{"token": ["C0085584#ent", "<e1>", "associated", "with", "protozoan", "and", "C0018889#ent", "<e2>", "side-effects", "of", "drugs", "commonly", "used", "to", "treat", "parasitoses", "may", "impair", "mood", "and", "cause", "anxiety", ",", "agitation", "or", "psychosis", "."], "h": {"id": "C0085584", "name": "C0085584#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018889", "name": "C0018889#ent", "pos": [6, 7]}}
{"token": ["Interleukin-15", "(", "C1334105#ent", "<e1>", ")", "is", "a", "potent", "C1522405#ent", "<e2>", "activator", "."], "h": {"id": "C1334105", "name": "C1334105#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1522405", "name": "C1522405#ent", "pos": [8, 9]}}
{"token": ["Moreover", ",", "affinity", "purifications", "dextranase", ",", "C0007641#ent", "<e1>", ",", "and", "pectinase", "were", "done", "by", "gels", "with", "C0011806#ent", "<e2>", ",", "cellulose", ",", "and", "pectin", "structures", ",", "respectively", "."], "h": {"id": "C0007641", "name": "C0007641#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0011806", "name": "C0011806#ent", "pos": [16, 17]}}
{"token": ["Diazepam", ",", "5", "mg/kg", ",", "C1419070#ent", "<e1>", ",", "blocked", "the", "stimulus", "produced", "by", "PTZ", ",", "and", "C0025029#ent", "<e2>", ",", "5", "mg/kg", ",", "C1419070#ent", "<e1>", ",", "blocked", "the", "stimulus", "produced", "by", "nicotine", "."], "h": {"id": "C1419070", "name": "C1419070#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025029", "name": "C0025029#ent", "pos": [16, 17]}}
{"token": ["The", "genome", "of", "Tacaribe", "virus", "TV", ")", ",", "prototype", "of", "the", "New", "World", "arenaviruses", "comprises", "two", "RNA", "segments", "encoding", "two", "C0086376#ent", "<e1>", "in", "an", "ambisense", "orientation", "separated", "by", "an", "intergenic", "region", "C3889721#ent", "<e2>", ")", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3889721", "name": "C3889721#ent", "pos": [31, 32]}}
{"token": ["Animals", "with", "a", "history", "of", "multiple", "seizures", "3", "x", "KA", ")", "were", "given", "KA", "on", "P6", ",", "C1424701#ent", "<e1>", ",", "and", "then", "on", "P20", "or", "C0069919#ent", "<e2>", "."], "h": {"id": "C1424701", "name": "C1424701#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0069919", "name": "C0069919#ent", "pos": [25, 26]}}
{"token": ["RNAPII", "core", "C0027203#ent", "<e1>", "is", "composed", "of", "12", "polypeptides", "where", "C1335231#ent", "<e2>", "is", "the", "largest", "subunit", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335231", "name": "C1335231#ent", "pos": [10, 11]}}
{"token": ["These", "results", "suggest", "that", "C1419270#ent", "<e1>", ",", "like", "the", "other", "C0072986#ent", "<e2>", "is", "a", "low", "molecular", "weight", "GTP-binding", "protein", "human", "platelets", "."], "h": {"id": "C1419270", "name": "C1419270#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072986", "name": "C0072986#ent", "pos": [10, 11]}}
{"token": ["The", "use", "of", "both", "C0812246#ent", "<e1>", "and", "serum", "tests", "AEmA", "and", "tTG", "reveals", "C0171406#ent", "<e2>", "cases", "not", "detected", "by", "C0812246#ent", "<e1>", "alone", "that", "respond", "to", "gluten-free", "diet"], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0812246", "name": "C0812246#ent", "pos": [4, 5]}}
{"token": ["Because", "C1968833#ent", "<e1>", "is", "ubiquitously", "expressed", ",", "our", "aim", "was", "to", "determine", "which", "cellular", "source(s", ")", "of", "C1968833#ent", "<e1>", "plays", "the", "central", "role", "in", "mediating", "C0014335#ent", "<e1>"], "h": {"id": "C1968833", "name": "C1968833#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014335", "name": "C0014335#ent", "pos": [25, 26]}}
{"token": ["Characteristic", "clinical", "findings", "include", "immediate", "onset", "of", "C0452136#ent", "<e1>", "with", "ipsilateral", "sixth", "and", "seventh", "C0028866#ent", "<e2>"], "h": {"id": "C0452136", "name": "C0452136#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028866", "name": "C0028866#ent", "pos": [14, 15]}}
{"token": ["Recent", "studies", "have", "implicated", "calmodulin", "in", "the", "Ca2", "+", "control", "of", "three", "C3541394#ent", "<e1>", "in", "skeletal", "muscle", "phosphorylase", "kinase", "myosin", "light", "chain", "kinase", "a", "C0033640#ent", "<e2>", "the", "sarcoplasmic", "reticulum"], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [24, 25]}}
{"token": ["Protein", "phosphorylation", "a", "post-translational", "modification", "by", "a", "group", "of", "C3541394#ent", "<e1>", "known", "as", "the", "C0033640#ent", "<e2>", "phosphotransferases", "(", "Enzyme", "Commission", "classification", ")", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [14, 15]}}
{"token": ["In", "patients", "with", "C0743332#ent", "<e1>", "abnormal", "digit", "representations", "the", "primary", "somatosensory", "cortex", "C1835435#ent", "<e2>", ")", "could", "be", "the", "result", "of", "enlarged", "and", "overlapping", "receptor", "fields", "as", "suggested", "by", "an", "animal", "model", "dystonia", "."], "h": {"id": "C0743332", "name": "C0743332#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1835435", "name": "C1835435#ent", "pos": [12, 13]}}
{"token": ["Unlike", "classical", "DHFR", "inhibitors", "with", "a", "glutamate", "side", "chain", "such", "as", "methotrexate", "and", "C0795939#ent", "<e1>", ",", "PT523", "can", "not", "form", "C0392213#ent", "<e2>", "."], "h": {"id": "C0795939", "name": "C0795939#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0392213", "name": "C0392213#ent", "pos": [20, 21]}}
{"token": ["Charcot-Marie-Tooth", "disease", "type", "1", "C2698698#ent", "<e1>", ")", "is", "a", "hereditary", "motor", "C0699739#ent", "<e2>"], "h": {"id": "C2698698", "name": "C2698698#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0699739", "name": "C0699739#ent", "pos": [11, 12]}}
{"token": ["This", "study", "shows", "that", "C0004096#ent", "<e1>", "adolescents", "prefer", "C0378466#ent", "<e2>", "a", "ratio", "of", "2.6:1", "over", "inhaled", "BDP", ",", "and", "these", "results", "may", "have", "implications", "for", "improving", "adolescent", "patient", "compliance", "with", "asthma", "therapy"], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0378466", "name": "C0378466#ent", "pos": [8, 9]}}
{"token": ["Therefore", ",", "interventions", "directed", "towards", "the", "potential", "mechanisms", "that", "promote", "C0042373#ent", "<e1>", "and", "occlusion", "in", "C0002895#ent", "<e2>", "be", "investigated", "."], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [15, 16]}}
{"token": ["PTP3", ",", "the", "C1955972#ent", "<e1>", "in", "Dictyostelium", "discoideum", "has", "a", "single", "C1335554#ent", "<e2>"], "h": {"id": "C1955972", "name": "C1955972#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [11, 12]}}
{"token": ["The", "results", "indicate", "that", "C2936569#ent", "<e1>", "protect", "against", "NMDA-evoked", "C0036572#ent", "<e2>", "and", "that", "the", "adenosine", "A1", "receptor", "be", "directly", "involved", "in", "these", "actions", "."], "h": {"id": "C2936569", "name": "C2936569#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [9, 10]}}
{"token": ["Selective", "elimination", "of", "MCN1", "and", "C1413857#ent", "<e1>", "access", "to", "the", "STG", "also", "prevents", "C1367690#ent", "<e2>", "activation", "of", "this", "rhythm", "."], "h": {"id": "C1413857", "name": "C1413857#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1367690", "name": "C1367690#ent", "pos": [13, 14]}}
{"token": ["The", "increase", "in", "C1415619#ent", "<e1>", "together", "with", "the", "decrease", "in", "C0030016#ent", "<e2>", "may", "be", "part", "of", "a", "common", "defense", "mechanism", "to", "minimize", "tissue", "damage", "several", "neurological", "conditions"], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030016", "name": "C0030016#ent", "pos": [10, 11]}}
{"token": ["The", "enhanced", "fibrinolytic", "potential", "attributed", "to", "increased", "urokinase", "plasminogen", "activator", "C1706177#ent", "<e1>", ")", ",", "probably", "released", "from", "perturbed", "endothelial", "cells", "C1416867#ent", "<e2>", "."], "h": {"id": "C1706177", "name": "C1706177#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [20, 21]}}
{"token": ["To", "characterise", "the", "clinical", "features", ",", "emergency", "pre-paediatric", "intensive", "care", "(", "C0730321#ent", "<e1>", ")", "treatment", ",", "and", "course", "of", "C0085543#ent", "<e2>", "SE", ")", "in", "children", "admitted", "to", "C0730321#ent", "<e1>", "."], "h": {"id": "C0730321", "name": "C0730321#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0085543", "name": "C0085543#ent", "pos": [19, 20]}}
{"token": ["Early", "imaging", "4", "-", "6", "h", "is", "useful", "to", "detect", "C4082764#ent", "<e1>", "whereas", "24", "h", "imaging", "is", "used", "to", "evaluate", "C0238990#ent", "<e2>"], "h": {"id": "C4082764", "name": "C4082764#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0238990", "name": "C0238990#ent", "pos": [20, 21]}}
{"token": ["Determination", "of", "the", "long", "term", "incidence", "of", "C0042749#ent", "<e1>", ",", "hypertension", ",", "and", "C0040524#ent", "<e2>", "in", "pregnancy", "associated", "with", "focal", "renal", "scarring", "after", "pyelonephritis", "in", "childhood", "25", "-", "35", "years", "earlier", "."], "h": {"id": "C0042749", "name": "C0042749#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040524", "name": "C0040524#ent", "pos": [13, 14]}}
{"token": ["The", "analysis", "of", "anamnestic", "data", "about", "early", "minimal", "brain", "damage", "C0005944#ent", "<e1>", ")", "differentiated", "4", "groups", ":", "with", "an", "without", "C0014547#ent", "<e2>", ",", "with", "and", "without", "C0005944#ent", "<e1>", "."], "h": {"id": "C0005944", "name": "C0005944#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [20, 21]}}
{"token": ["Cells", "were", "stimulated", "with", "the", "Ca(2+)-", "elevating", "C0991617#ent", "<e1>", "ATP", "and", "ionomycin", "in", "isotonic", "medium", "or", "in", "C0020677#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020677", "name": "C0020677#ent", "pos": [17, 18]}}
{"token": ["However", ",", "the", "presence", "of", "aCL", "antibodies", "especially", "in", "conjunction", "with", "anti-beta2", "GP1", "antibodies", ",", "suggests", "that", "in", "some", "patients", ",", "C0018784#ent", "<e1>", "is", "included", "among", "the", "rare", "symptoms", "of", "the", "C0085278#ent", "<e2>"], "h": {"id": "C0018784", "name": "C0018784#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0085278", "name": "C0085278#ent", "pos": [31, 32]}}
{"token": ["To", "determine", "whether", "IP-10", "and", "C1332821#ent", "<e1>", "are", "released", "during", "bacterial", "infection", "humans", ",", "we", "measured", "plasma", "levels", "of", "IP-10", "and", "C1332821#ent", "<e1>", "in", "patients", "with", "C0025229#ent", "<e1>", ",", "a", "severe", "gram-negative", "infection", "by", "Burkholderia", "pseudomallei"], "h": {"id": "C1332821", "name": "C1332821#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025229", "name": "C0025229#ent", "pos": [26, 27]}}
{"token": ["In", "acutely", "C0231218#ent", "<e1>", "HIT", "patients", ",", "C0048470#ent", "<e2>", ",", "versus", "historical", "control", "provides", "effective", "antithrombotic", "therapy", "increasing", "major", "bleeding", "."], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0048470", "name": "C0048470#ent", "pos": [7, 8]}}
{"token": ["Observation", "of", "patients", "with", "recurrent", "C0026946#ent", "<e1>", "revealed", "that", "repeated", "monotherapy", "with", "C0076110#ent", "<e2>", "or", "itraconazole", "is", "the", "least", "efficient", "regimen", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0076110", "name": "C0076110#ent", "pos": [12, 13]}}
{"token": ["C0206172#ent", "<e1>", "among", "the", "most", "common", "severe", "complications", "of", "C0011849#ent", "<e2>", ",", "affecting", "up", "to", "68", "per", "1,000", "persons", "with", "C0011849#ent", "<e2>", "per", "year", "in", "the", "United", "States"], "h": {"id": "C0206172", "name": "C0206172#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["In", "consuming", "H2O2", "and", "being", "reduced", "by", "glutathione", ",", "C0377952#ent", "<e1>", "acts", "as", "a", "C0017822#ent", "<e2>", "replaces", "the", "function", "of", "the", "enzyme", "in", "eggs", "."], "h": {"id": "C0377952", "name": "C0377952#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017822", "name": "C0017822#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "of", "a", "single", "oral", "dose", "C0033497#ent", "<e1>", "(", "120", "mg", ")", "on", "C0270736#ent", "<e2>", "investigated", "in", "a", "double-blind", ",", "placebo-controlled", "study", "26", "patients", "."], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0270736", "name": "C0270736#ent", "pos": [14, 15]}}
{"token": ["When", "C3890227#ent", "<e1>", "by", "transient", "transfection", ",", "SMRT", "inhibits", "C2001899#ent", "<e2>", "promoter", "activity", "induced", "by", "interleukin-1", "(", "IL-1", ")", ",", "phorbol", "phorbol", "myristate", "acetate", "PMA", ")", "or", "v-Src", "."], "h": {"id": "C3890227", "name": "C3890227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2001899", "name": "C2001899#ent", "pos": [9, 10]}}
{"token": ["Loss", "of", "C1425762#ent", "<e1>", "expression", "correlates", "with", "loss", "of", "C1332818#ent", "<e2>", "secretion", "by", "head", "and", "neck", "squamous", "cell", "carcinoma", "cell", "lines", "whereas", "reintroduction", "of", "C1425762#ent", "<e1>", "restores", "C1332818#ent", "<e2>", "secretion", "."], "h": {"id": "C1425762", "name": "C1425762#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332818", "name": "C1332818#ent", "pos": [9, 10]}}
{"token": ["With", "monitoring", ",", "patient", "education", "and", "continued", "research", "to", "further", "elucidate", "risk", "factors", "C0060135#ent", "<e1>", "can", "be", "a", "viable", "therapeutic", "agent", "patients", "with", "C0014544#ent", "<e2>", "."], "h": {"id": "C0060135", "name": "C0060135#ent", "pos": [13, 14]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [23, 24]}}
{"token": ["Felbamate", "(", "C0060135#ent", "<e1>", "is", "clinically", "available", "for", "the", "treatment", "of", "refractory", "C0014544#ent", "<e2>", "and", "is", "known", "to", "modulate", "several", "ion", "channels", "gamma-aminobutyric", "acid", "type", "A", "GABA(A", ")", ")", "receptors", "."], "h": {"id": "C0060135", "name": "C0060135#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [12, 13]}}
{"token": ["Previous", "studies", "have", "demonstrated", "that", "felbamate", "(", "FBM", ",", "C0060135#ent", "<e1>", "at", "nontoxic", "doses", "potent", "anticonvulsant", "activity", "a", "variety", "of", "C0014544#ent", "<e2>", "seizure", "models", "."], "h": {"id": "C0060135", "name": "C0060135#ent", "pos": [9, 10]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [20, 21]}}
{"token": ["Ghilanten", "consists", "of", "119", "C3539947#ent", "<e1>", "twenty", "cysteines", "and", "a", "consensus", "sequence", "C1332127#ent", "<e2>", "at", "its", "carboxyl-terminus", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332127", "name": "C1332127#ent", "pos": [12, 13]}}
{"token": ["Congenital", "C1096184#ent", "<e1>", "infection", "has", "been", "accompanied", "by", "C0008513#ent", "<e2>", "severe", "malformation", "of", "the", "fetal", "central", "nervous", "system"], "h": {"id": "C1096184", "name": "C1096184#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0008513", "name": "C0008513#ent", "pos": [8, 9]}}
{"token": ["We", "demonstrated", "that", "IL-1beta-induced", "downregulation", "of", "C0013765#ent", "<e1>", "mRNA", "is", "dependent", "on", "C1417708#ent", "<e2>", "C/EBPbeta", "expression", "."], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417708", "name": "C1417708#ent", "pos": [12, 13]}}
{"token": ["To", "this", "end", ",", "different", "fusion", "proteins", "of", "the", "extracellular", "domain", "tissue", "factor", "truncated", "tissue", "factor", "C1705840#ent", "<e1>", ")", "were", "fused", "to", "the", "peptides", "C0061709#ent", "<e2>", "(", "abbr", "."], "h": {"id": "C1705840", "name": "C1705840#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0061709", "name": "C0061709#ent", "pos": [24, 25]}}
{"token": ["Drug", "therapy", "the", "treatment", "of", "obstetric", "emergencies", "consists", "of", "medications", "not", "commonly", "used", "by", "the", "emergency", "physician", "as", "Rho(D", ")", "immune", "globulin", "C0007047#ent", "<e1>", "carboprost", ")", ",", "and", "C0356649#ent", "<e2>"], "h": {"id": "C0007047", "name": "C0007047#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0356649", "name": "C0356649#ent", "pos": [28, 29]}}
{"token": ["C0021099#ent", "<e1>", "considered", "to", "be", "a", "C0038160#ent", "<e2>"], "h": {"id": "C0021099", "name": "C0021099#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0038160", "name": "C0038160#ent", "pos": [6, 7]}}
{"token": ["Western", "blot", "real-time", "PCR", "showed", "that", "a", "dose-dependent", "increase", "of", "the", "proapoptotic", "BH3-only", "proteins", "C1321914#ent", "<e1>", "and", "Puma", "contributed", "to", "the", "cell", "death", "induced", "by", "C2698930#ent", "<e2>", "and", "to", "the", "synergistic", "effects", "C2698930#ent", "<e2>", "and", "docetaxel", "."], "h": {"id": "C1321914", "name": "C1321914#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2698930", "name": "C2698930#ent", "pos": [25, 26]}}
{"token": ["Consecutive", "reactions", "of", "two", "enzymes", ",", "C3489580#ent", "<e1>", "MDH", ")", "and", "serine", "hydroxymethyltransferase", "C3538858#ent", "<e2>", ")", "are", "involved", "in", "the", "production", "."], "h": {"id": "C3489580", "name": "C3489580#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3538858", "name": "C3538858#ent", "pos": [13, 14]}}
{"token": ["A", "total", "of", "71", "sera", "had", "positive", "reactions", "C0285526#ent", "<e1>", "and", "those", "sera", "were", "also", "positive", "in", "C3540469#ent", "<e2>", "."], "h": {"id": "C0285526", "name": "C0285526#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540469", "name": "C3540469#ent", "pos": [17, 18]}}
{"token": ["Liver", "tissue", "fatty", "degeneration", "from", "animals", "poisoned", "with", "phosphorus", "or", "C0008232#ent", "<e1>", "contains", "a", "decreased", "amount", "of", "C0014894#ent", "<e2>", "."], "h": {"id": "C0008232", "name": "C0008232#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014894", "name": "C0014894#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "sera", "from", "10", "patients", "with", "C0001403#ent", "<e1>", "10", "patients", "with", "vitiligo", "(", "without", "associated", "C1705846#ent", "<e2>", ")", "were", "all", "negative", "for", "antibody", "reactivity", "to", "the", "symporter", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705846", "name": "C1705846#ent", "pos": [17, 18]}}
{"token": ["In", "the", "absence", "of", "C0042075#ent", "<e1>", "the", "treatment", "of", "lower", "C0042029#ent", "<e2>", "the", "woman", "is", "not", "based", "upon", "any", "particular", "rules", "since", "short-term", "treatment", "seems", "just", "as", "effective", "as", "long-term", "treatment", "."], "h": {"id": "C0042075", "name": "C0042075#ent", "pos": [4, 5]}, "relation": "nichd_parent_of", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [10, 11]}}
{"token": ["All", "strains", "were", "included", "in", "a", "multilocus", "sequence", "analysis", "MLSA", ")", "study", "for", "species", "identification", "of", "Lactobacillus", "using", "the", "C1417679#ent", "<e1>", "encoding", "the", "phenylalanyl-tRNA", "synthase", "alpha", "subunit", "pheS", ")", "and", "C0754910#ent", "<e2>", "rpoA", ")", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0754910", "name": "C0754910#ent", "pos": [30, 31]}}
{"token": ["Antibodies", "directed", "against", "certain", "macrophage", "surface", "glycoproteins", "i.e.", ",", "C1416831#ent", "<e1>", "and", "Mac-3", ")", "and", "those", "against", "lysosome-associated", "membrane", "glycoproteins", "i.e.", ",", "C3540818#ent", "<e2>", "and", "LAMP-2", ")", "reacted", "specifically", "with", "cell", "surface", "determinants", "on", "the", "embryos", "."], "h": {"id": "C1416831", "name": "C1416831#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3540818", "name": "C3540818#ent", "pos": [22, 23]}}
{"token": ["The", "present", "family", "emphasises", "that", "C0231528#ent", "<e1>", "is", "a", "prominent", "symptom", "in", "C3273677#ent", "<e2>", "and", "the", "clinical", "differences", "be", "explained", "by", "genetic", "heterogeneity"], "h": {"id": "C0231528", "name": "C0231528#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273677", "name": "C3273677#ent", "pos": [12, 13]}}
{"token": ["There", "is", "a", "clear", "correlation", "between", "patient's", "satisfaction", "with", "C1705581#ent", "<e1>", "done", "for", "C0877389#ent", "<e2>", "and", "the", "correction", "of", "femorotibial", "deformity", "."], "h": {"id": "C1705581", "name": "C1705581#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0877389", "name": "C0877389#ent", "pos": [13, 14]}}
{"token": ["However", ",", "the", "C1969646#ent", "<e1>", "did", "recommend", "stopping", "C1135135#ent", "<e2>", "at", "the", "time", "of", "disease", "progression", "at", "the", "start", "of", "second-line", "therapy"], "h": {"id": "C1969646", "name": "C1969646#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1135135", "name": "C1135135#ent", "pos": [8, 9]}}
{"token": ["These", "findings", "are", "linked", "to", "the", "development", "of", "C0156312#ent", "<e1>", "cases", "of", "severe", "C0023374#ent", "<e2>", "man", "."], "h": {"id": "C0156312", "name": "C0156312#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C0023374", "name": "C0023374#ent", "pos": [13, 14]}}
{"token": ["C0302361#ent", "<e1>", "152", "isolates", ")", "and", "C0302359#ent", "<e2>", "151", "isolates", ")", "were", "the", "most", "common", "species", "."], "h": {"id": "C0302361", "name": "C0302361#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0302359", "name": "C0302359#ent", "pos": [6, 7]}}
{"token": ["When", "short-chain", "fatty", "acids", "C0025517#ent", "<e1>", "by", "hepatocytes", ",", "C1706611#ent", "<e2>", "is", "readily", "formed", "within", "the", "matrix", "by", "the", "butyryl-CoA", "ligase", "AMP-forming", ")", "reaction", "(", "EC", "6.2.1.2", ")", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706611", "name": "C1706611#ent", "pos": [9, 10]}}
{"token": ["During", "this", "culture", "period", "GAL", "but", "not", "C1420280#ent", "<e1>", "continued", "to", "express", "C1538265#ent", "<e2>", "killing", "against", "natural", "killer-resistant", "tumor", "targets", "."], "h": {"id": "C1420280", "name": "C1420280#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538265", "name": "C1538265#ent", "pos": [12, 13]}}
{"token": ["This", "substrate", "is", "cleaved", "by", "trypsin", ",", "chymotrypsin", ",", "C0030306#ent", "<e1>", ",", "subtilisin", ",", "and", "C0039815#ent", "<e2>", "in", "a", "linear", "time-dependent", "manner", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039815", "name": "C0039815#ent", "pos": [15, 16]}}
{"token": ["The", "C0012906#ent", "<e1>", "Apal", ",", "Xbal", ",", "and", "C0812377#ent", "<e2>", "were", "found", "to", "be", "most", "useful", "for", "comparison", "of", "plasmid", "DNAs", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0812377", "name": "C0812377#ent", "pos": [8, 9]}}
{"token": ["Human", "chromosome", "banding", "carried", "out", "with", "C0012906#ent", "<e1>", "REs", ")", "HaeIII", ",", "HinfI", ",", "C0812377#ent", "<e2>", "and", "the", "effects", "of", "factors", "on", "it", "were", "examined", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812377", "name": "C0812377#ent", "pos": [14, 15]}}
{"token": ["The", "most", "relevant", "clinical", "aspects", "hyperprolactinemia", ",", "acromegaly", ",", "Cushing's", "disease", "secondary", "hyperthyroidism", "C0039082#ent", "<e1>", "of", "inappropriate", "ADH", "secretion", ",", "C0020635#ent", "<e2>", ",", "growth", "hormone", "deficiency", "gonadotropin", "deficiency", "ACTH", "deficiency", "TSH", "deficiency", "and", "diabetes", "insipidus", "discussed", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020635", "name": "C0020635#ent", "pos": [20, 21]}}
{"token": ["Twenty", "cases", "with", "32", "C1290398#ent", "<e1>", "eight", "families", "of", "C0007766#ent", "<e2>", "presented", "."], "h": {"id": "C1290398", "name": "C1290398#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0007766", "name": "C0007766#ent", "pos": [9, 10]}}
{"token": ["In", "mammalian", "cells", "a", "multiprotein", "complex", "of", "WAVE", ",", "PIR121/Sra-1", ",", "Nap1", ",", "C1332005#ent", "<e1>", "and", "HSPC300", "mediates", "responsiveness", "of", "WAVE", "to", "upstream", "regulators", "as", "C0285558#ent", "<e2>", "."], "h": {"id": "C1332005", "name": "C1332005#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0285558", "name": "C0285558#ent", "pos": [25, 26]}}
{"token": ["Splenocytes", "from", "IFN", "C4284124#ent", "<e1>", "mice", "stimulated", "with", "a", "C0026249#ent", "<e2>", "proliferated", "to", "a", "significantly", "greater", "extent", "and", "produced", "more", "IL-2", "compared", "with", "splenocytes", "obtained", "from", "IL-4", "C4284124#ent", "<e1>", "or", "control", "mice"], "h": {"id": "C4284124", "name": "C4284124#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [9, 10]}}
{"token": ["The", "other", "two", ",", "C1824035#ent", "<e1>", "and", "ZNF75C", ",", "maintain", "an", "C0079941#ent", "<e2>", "in", "the", "sequenced", "region", "and", "at", "least", "the", "latter", "is", "expressed", "in", "the", "U937", "cell", "line", "."], "h": {"id": "C1824035", "name": "C1824035#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079941", "name": "C0079941#ent", "pos": [11, 12]}}
{"token": ["We", "report", "a", "girl", "with", "the", "C0004763#ent", "<e1>", "had", "acute", "encephalopathy", "induced", "by", "calcium", "hopantenate", "C1537677#ent", "<e2>", ")", "."], "h": {"id": "C0004763", "name": "C0004763#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1537677", "name": "C1537677#ent", "pos": [15, 16]}}
{"token": ["In", "conclusion", ",", "3D", "echocardiography", "be", "utilized", "to", "follow", "C1420423#ent", "<e1>", "function", "after", "C2984561#ent", "<e2>", "for", "HCM", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2984561", "name": "C2984561#ent", "pos": [13, 14]}}
{"token": ["In", "our", "study", ",", "we", "purified", "C1826761#ent", "<e1>", "from", "human", "colon", "to", "apparent", "homogeneity", ",", "sequenced", "two", "C0030956#ent", "<e2>", "after", "proteolytic", "digestion", ",", "and", "demonstrated", "that", "the", "C1826761#ent", "<e1>", "belongs", "to", "the", "tropomyosin", "family"], "h": {"id": "C1826761", "name": "C1826761#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [17, 18]}}
{"token": ["Clinically", "important", "\"", "newer", "\"", "C0035064#ent", "<e1>", "include", "members", "of", "the", "echinocandin", "class", "eg", ",", "C0537894#ent", "<e2>", ")", "and", "second-generation", "triazoles", "(", "eg", ",", "voriconazole", "and", "posaconazole", ")", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0537894", "name": "C0537894#ent", "pos": [15, 16]}}
{"token": ["Selenoprotein", "S1", "C1842829#ent", "<e1>", ")", ",", "a", "novel", "C0017337#ent", "<e2>", "involved", "in", "the", "stress", "response", "endoplasmic", "reticulum", "inflammation", "control"], "h": {"id": "C1842829", "name": "C1842829#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [8, 9]}}
{"token": ["Identification", "and", "characterization", "of", "C3179455#ent", "<e1>", "C2698416#ent", "<e2>", ")", "has", "established", "C2698416#ent", "<e2>", "as", "an", "essential", "protein", "in", "the", "intestinal", "cholesterol", "absorption", "."], "h": {"id": "C3179455", "name": "C3179455#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2698416", "name": "C2698416#ent", "pos": [6, 7]}}
{"token": ["On", "the", "basis", "of", "homology", "comparisons", ",", "some", "of", "them", "could", "be", "assigned", "to", "possible", "functions", ",", "such", "as", "a", "C1333949#ent", "<e1>", ",", "a", "nucleic", "acid", "polymerase", "a", "C0030946#ent", "<e2>", "."], "h": {"id": "C1333949", "name": "C1333949#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [28, 29]}}
{"token": ["32P-DFP", ",", "which", "binds", "to", "the", "active", "site", "C0036734#ent", "<e1>", "was", "added", "to", "serum", "free", "medium", "from", "normal", "and", "C3890184#ent", "<e2>", "cultures", "."], "h": {"id": "C0036734", "name": "C0036734#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3890184", "name": "C3890184#ent", "pos": [19, 20]}}
{"token": ["DAX-1", "may", "therefore", "play", "a", "separate", "or", "complementary", "role", "to", "that", "of", "C1417838#ent", "<e1>", "in", "the", "modulation", "of", "C0039591#ent", "<e2>", "expression", "and", "differentiation", "."], "h": {"id": "C1417838", "name": "C1417838#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0039591", "name": "C0039591#ent", "pos": [18, 19]}}
{"token": ["To", "evaluate", "this", "possibility", ",", "the", "effect", "of", "C0042523#ent", "<e1>", "on", "the", "median", "lethal", "dose", "LD50", ")", "of", "lidocaine", "and", "C0887621#ent", "<e2>", "in", "mice", "was", "determined", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0887621", "name": "C0887621#ent", "pos": [20, 21]}}
{"token": ["Therefore", ",", "it", "was", "considered", "that", "the", "BA", "of", "C0010592#ent", "<e1>", "after", "treatment", "with", "RTV-boosted", "C1334862#ent", "<e2>", "would", "decrease", "by", "the", "induction", "effect", "of", "RTV", "in", "chronic", "phase", "described", "above", "."], "h": {"id": "C0010592", "name": "C0010592#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334862", "name": "C1334862#ent", "pos": [15, 16]}}
{"token": ["Ipratropium", "is", "a", "useful", "C0013227#ent", "<e1>", "in", "the", "treatment", "of", "C1260880#ent", "<e2>", "appears", "safe", "for", "long-term", "use", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [10, 11]}}
{"token": ["C1420610#ent", "<e1>", "is", "a", "C0913648#ent", "<e2>", "expressed", "in", "several", "hematopoietic", "cell", "types"], "h": {"id": "C1420610", "name": "C1420610#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0913648", "name": "C0913648#ent", "pos": [4, 5]}}
{"token": ["The", "dose", "of", "3", "mg/kg", "of", "C0068390#ent", "<e1>", "(", "1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine", ")", "produced", "a", "slight", "decrease", "in", "C0721797#ent", "<e2>", "added", "to", "the", "suppression", "of", "C0721797#ent", "<e2>", "low", "doses", "flesinoxan", "via", "an", "uncertain", "mechanism", "."], "h": {"id": "C0068390", "name": "C0068390#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0721797", "name": "C0721797#ent", "pos": [16, 17]}}
{"token": ["To", "better", "understand", "the", "cellular", "function", "RSC", ",", "a", "screen", "was", "undertaken", "for", "gene", "dosage", "of", "sth1", "-", "3ts", ",", "a", "temperature-sensitive", "mutation", "C1423842#ent", "<e1>", ",", "which", "encodes", "the", "essential", "C1412687#ent", "<e2>"], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1412687", "name": "C1412687#ent", "pos": [30, 31]}}
{"token": ["An", "antibody", "to", "unsulfated", "C0020197#ent", "<e1>", "strongly", "immunostained", "intracellular", "NFTs", "and", "the", "dystrophic", "neurites", "of", "C1843919#ent", "<e2>", "."], "h": {"id": "C0020197", "name": "C0020197#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1843919", "name": "C1843919#ent", "pos": [15, 16]}}
{"token": ["Alternative", "diagnostic", "labels", "allergy", ",", "bronchitis", "(", "C0043144#ent", "<e1>", ")", ",", "pneumonia", "(", "chest", "infection", ",", "and", "C0041323#ent", "<e2>", ",", "were", "used", "in", "29", "(", "64.4", "%", ")", "."], "h": {"id": "C0043144", "name": "C0043144#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [17, 18]}}
{"token": ["During", "C0032285#ent", "<e1>", "increased", "amounts", "of", "reactive", "oxygen", "species", "C0289313#ent", "<e2>", ")", "and", "reactive", "nitrogen", "intermediates", "(", "RNI", ")", "are", "produced", "as", "a", "consequence", "of", "phagocyte", "respiratory", "burst"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [9, 10]}}
{"token": ["Ovarian", "follicular", "development", "involves", "continual", "remodelling", "of", "the", "extracellular", "matrix", "C3889469#ent", "<e1>", ")", "forming", "the", "basement", "membrane", "intercellular", "framework", "that", "support", "granulosa", "cell", "C1367452#ent", "<e2>", ")", "growth", "and", "differentiation", "."], "h": {"id": "C3889469", "name": "C3889469#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [23, 24]}}
{"token": ["C1416540#ent", "<e1>", "isolated", "from", "rat", "liver", "cleaves", "C0007158#ent", "<e2>", "5-Fluorouridine", "and", "5-Fluoro-2'-deoxyuridine", "to", "generate", "5-Fluorouracil", "."], "h": {"id": "C1416540", "name": "C1416540#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007158", "name": "C0007158#ent", "pos": [7, 8]}}
{"token": ["Furthermore", ",", "ectopic", "C1704894#ent", "<e1>", "expression", "exacerbates", "C1336596#ent", "<e2>", "haplo-insufficiency", "in", "B-cell", "differentiation", "indicating", "that", "C1704894#ent", "<e1>", "genetically", "interacts", "with", "C1336596#ent", "<e2>", "."], "h": {"id": "C1704894", "name": "C1704894#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1336596", "name": "C1336596#ent", "pos": [7, 8]}}
{"token": ["The", "results", "of", "phantom", "experiments", "showed", "increased", "signal-to-noise", "ratio", "SNR", ")", "with", "prolonging", "repetition", "time", "C1705610#ent", "<e1>", ")", "on", "both", "3D", "C1539477#ent", "<e2>", "and", "3D", "FSE", "sequences", "."], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1539477", "name": "C1539477#ent", "pos": [21, 22]}}
{"token": ["These", "results", "underscore", "that", "the", "beneficial", "effect", "of", "an", "C1422646#ent", "<e1>", "on", "protein", "excretion", "paralleled", "by", "a", "substantial", "reduction", "in", "intrarenal", "C1417809#ent", "<e2>", "release", "."], "h": {"id": "C1422646", "name": "C1422646#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417809", "name": "C1417809#ent", "pos": [21, 22]}}
{"token": ["In", "the", "C0040610#ent", "<e1>", "and", "the", "Tramadol-Lidocaine", "Groups", ",", "the", "incidence", "of", "skin", "rash", "C0030193#ent", "<e2>", "or", "burning", "sensation", "the", "injection", "site", "increased", "."], "h": {"id": "C0040610", "name": "C0040610#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [14, 15]}}
{"token": ["C3494506#ent", "<e1>", "a", "rare", "C1848862#ent", "<e2>", ",", "in", "which", "cutaneous", "and", "superficial", "soft", "tissue", "lesions", "traditionally", "include", "osteomas", "and", "calcifications", "."], "h": {"id": "C3494506", "name": "C3494506#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}}
{"token": ["All", "C0018799#ent", "<e1>", "disappeared", "after", "IV", "atropine", "and", "C0022180#ent", "<e2>", "administration", "instead", "of", "propofol", "infusion", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [8, 9]}}
{"token": ["A", "38-year-old", "C0362046#ent", "<e1>", "female", "developed", "fatal", "hypoglycemia", "when", "chlorpropamide", "(", "C0591359#ent", "<e2>", ")", "was", "accidentally", "substituted", "for", "acetaminophen", "(", "Tylenol", ")", "with", "codeine", "no.", "3", "in", "a", "pharmacy", "dispensing", "error"], "h": {"id": "C0362046", "name": "C0362046#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0591359", "name": "C0591359#ent", "pos": [11, 12]}}
{"token": ["The", "distinction", "between", "amelogenesis", "imperfecta", "with", "C0266039#ent", "<e1>", "and", "the", "C0265333#ent", "<e2>", "discussed", "."], "h": {"id": "C0266039", "name": "C0266039#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C0265333", "name": "C0265333#ent", "pos": [10, 11]}}
{"token": ["Additionally", ",", "a", "specific", "C1514555#ent", "<e1>", "RO318220", ")", "inhibited", "CD8-mediated", "enhancement", "of", "C0879590#ent", "<e2>", "production", "far", "more", "effectively", "than", "CD4-mediated", "enhancement", "."], "h": {"id": "C1514555", "name": "C1514555#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0879590", "name": "C0879590#ent", "pos": [12, 13]}}
{"token": ["Both", "wild-type", "TGF-beta", "RI", "and", "a", "C1453853#ent", "<e1>", "mutant", "thereof", "are", "C0031727#ent", "<e2>", "by", "the", "coexpressed", "TGF-beta", "RII", "kinase", "in", "a", "ligand-independent", "fashion", "in", "these", "cells", "."], "h": {"id": "C1453853", "name": "C1453853#ent", "pos": [6, 7]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["The", "probe", "included", "the", "C0017337#ent", "<e1>", "for", "beta-galactosidase", "of", "E.", "coli", "the", "control", "of", "vaccinia", "virus", "C0072366#ent", "<e2>", "as", "well", "as", "the", "C0017337#ent", "<e1>", "for", "kanamycin", "resistance", "."], "h": {"id": "C0072366", "name": "C0072366#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}}
{"token": ["C0268487#ent", "<e1>", "in", "the", "glucose-6-phosphate", "transporter", "G6PT", ")", "cause", "C0017922#ent", "<e2>", "GSD-1b", ")", ",", "a", "heritable", "metabolic", "disorder"], "h": {"id": "C0268487", "name": "C0268487#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017922", "name": "C0017922#ent", "pos": [9, 10]}}
{"token": ["Free-floating", "adrenal", "gland", "sections", "hybridized", "with", "35S-labeled", "cDNA", "probes", "for", "tyrosine", "hydroxylase", "TH", ")", ",", "dopamine", "beta-hydroxylase", "DBH", ")", ",", "phenylethanolamine", "N-methyltransferase", "C3541302#ent", "<e1>", ")", ",", "PAM", ",", "and", "C1417815#ent", "<e2>", "."], "h": {"id": "C3541302", "name": "C3541302#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [29, 30]}}
{"token": ["Endoneurial", "capillary", "abnormalities", "have", "been", "assessed", "quantitatively", "in", "sural", "nerve", "biopsies", "diabetic", "patients", "with", "different", "syndromes", "of", "C0152025#ent", "<e1>", "chronic", "painful", "neuropathy", ",", "newly", "presenting", "C3276706#ent", "<e2>", "and", "painless", "neuropathy", "associated", "with", "neurotrophic", "foot", "ulceration"], "h": {"id": "C0152025", "name": "C0152025#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3276706", "name": "C3276706#ent", "pos": [25, 26]}}
{"token": ["Allele", "4", "the", "CA", "marker", "the", "C1417387#ent", "<e1>", "consisting", "of", "nine", "CA", "repeats", "was", "the", "most", "common", "C1706112#ent", "<e2>", "found", "in", "both", "the", "case", "and", "control", "triads", "."], "h": {"id": "C1417387", "name": "C1417387#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [17, 18]}}
{"token": ["To", "determine", "whether", "comorbid", "anxiety", "C2712370#ent", "<e1>", "response", "to", "methylphenidate", "(", "C0025810#ent", "<e2>", ")", "in", "children", "with", "attention-deficit", "hyperactivity", "disorder", "ADHD", ")", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0025810", "name": "C0025810#ent", "pos": [11, 12]}}
{"token": ["NMA", "injections", "destroyed", "the", "neurons", "of", "the", "IGL", "and", "the", "adjacent", "ventral", "dorsal", "divisions", "of", "the", "C1428865#ent", "<e1>", "and", "greatly", "reduced", "C1705518#ent", "<e2>", "immunoreactivity", "in", "the", "SCN", "."], "h": {"id": "C1428865", "name": "C1428865#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705518", "name": "C1705518#ent", "pos": [21, 22]}}
{"token": ["Human", "patients", "with", "dominant-negative", "mutations", "the", "Stat3", "gene", "recurrent", "C0032285#ent", "<e1>", ",", "suggesting", "a", "role", "for", "C1367307#ent", "<e2>", "in", "pulmonary", "host", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367307", "name": "C1367307#ent", "pos": [16, 17]}}
{"token": ["We", "have", "used", "mice", "rendered", "deficient", "for", "nitric", "oxide", "synthase", "2", "C1417760#ent", "<e1>", ")", "production", "to", "study", "the", "role", "of", "C0669372#ent", "<e2>", "NO", ")", "in", "the", "pathogenesis", "of", "allergic", "airways", "disease"], "h": {"id": "C1417760", "name": "C1417760#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [20, 21]}}
{"token": ["We", "found", "MRI", "superior", "to", "C3813556#ent", "<e1>", "in", "establishing", "the", "case", "of", "C0020635#ent", "<e2>", "."], "h": {"id": "C3813556", "name": "C3813556#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020635", "name": "C0020635#ent", "pos": [12, 13]}}
{"token": ["Elevated", "expression", "of", "C0138869#ent", "<e1>", "was", "found", "during", "the", "apoptosis", "induced", "by", "C0015133#ent", "<e2>", ",", "whereas", "most", "of", "C0138869#ent", "<e1>", "was", "proteolytically", "processed", "during", "apoptosis", "induced", "by", "cycloheximide", "and", "serum-withdrawal", "."], "h": {"id": "C0015133", "name": "C0015133#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0138869", "name": "C0138869#ent", "pos": [3, 4]}}
{"token": ["Nucleotide", "and", "amino", "acid", "sequence", "analysis", "AS", "to", "be", "a", "new", "member", "of", "the", "NRD1beta", "family", "of", "C0085249#ent", "<e1>", "placed", "the", "enzyme", "into", "the", "group", "of", "plant", "secondary", "product", "C0040517#ent", "<e2>", "."], "h": {"id": "C0085249", "name": "C0085249#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [29, 30]}}
{"token": ["These", "positions", "are", "conserved", "in", "other", "C0028954#ent", "<e1>", ",", "and", "they", "form", "tight", "and", "non-specific", "contacts", "C0065374#ent", "<e2>", ",", "enalapril", "and", "BPP9a", "inhibitors", "."], "h": {"id": "C0028954", "name": "C0028954#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0065374", "name": "C0065374#ent", "pos": [16, 17]}}
{"token": ["Overall", ",", "259", "of", "the", "372", "(", "70", "%", ")", "isolates", "were", "sensitive", "to", "C0038760#ent", "<e1>", ",", "identical", "results", "being", "obtained", "with", "sulphadiazine", ",", "C0038745#ent", "<e2>", "and", "a", "trimethoprim-sulphamethoxazole", "combination"], "h": {"id": "C0038760", "name": "C0038760#ent", "pos": [14, 15]}, "relation": "chemical_structure_of", "t": {"id": "C0038745", "name": "C0038745#ent", "pos": [24, 25]}}
{"token": ["In", "Saccharomyces", "cerevisiae", "C1382029#ent", "<e1>", "is", "controlled", "by", "C1537502#ent", "<e2>", "and", "Ras2p", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [8, 9]}}
{"token": ["Two", "cell", "specific", "C0030940#ent", "<e1>", "tryptase", "and", "C0055673#ent", "<e2>", ",", "are", "produced", "by", "human", "mast", "cells", "MC", ")", "."], "h": {"id": "C0030940", "name": "C0030940#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [7, 8]}}
{"token": ["Increased", "expression", "of", "both", "C1413391#ent", "<e1>", "has", "been", "observed", "in", "different", "pathological", "conditions", ":", "C3502322#ent", "<e2>", "in", "lysosomal", "lipid", "storage", "disorders", "like", "Gaucher", "disease", "AMCase", "in", "asthmatic", "lung", "disease"], "h": {"id": "C1413391", "name": "C1413391#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3502322", "name": "C3502322#ent", "pos": [14, 15]}}
{"token": ["C1705325#ent", "<e1>", "ERK1/2", "phosphorylation", "was", "significantly", "inhibited", "by", "C1417819#ent", "<e2>", ",", "thereby", "suggesting", "that", "both", "of", "these", "pathways", "may", "be", "activated", "via", "Src", "kinase"], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417819", "name": "C1417819#ent", "pos": [8, 9]}}
{"token": ["C1274184#ent", "<e1>", "the", "presenting", "sign", "the", "multiple", "lentigines", "syndrome", "C0175704#ent", "<e2>", "in", "a", "young", "woman", "."], "h": {"id": "C1274184", "name": "C1274184#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0175704", "name": "C0175704#ent", "pos": [9, 10]}}
{"token": ["A", "kidney", "and", "skin", "biopsy", "performed", "on", "a", "patient", "who", "developed", "cryoglobulinemia", ",", "C0162323#ent", "<e1>", ",", "a", "purpuric", "skin", "rash", "and", "C0022660#ent", "<e2>", "years", "following", "jejunoileal", "bypass", "morbid", "obesity"], "h": {"id": "C0162323", "name": "C0162323#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [21, 22]}}
{"token": ["Although", "cardiac", "CT-1", "gene", "expression", "is", "known", "to", "be", "upregulated", "in", "some", "animal", "models", "C0018802#ent", "<e1>", "the", "activation", "state", "the", "C1332801#ent", "<e2>", "patients", "with", "C0018802#ent", "<e1>", "unknown", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [14, 15]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332801", "name": "C1332801#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", "to", "amino-terminal", "fragments", ",", "those", "derived", "from", "the", "carboxy-terminal", "part", "EF-1", "beta", "still", "active", "in", "enhancing", "the", "C0120465#ent", "<e1>", "GDP", "bound", "to", "C0059036#ent", "<e2>"], "h": {"id": "C0120465", "name": "C0120465#ent", "pos": [19, 20]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0059036", "name": "C0059036#ent", "pos": [24, 25]}}
{"token": ["Therefore", ",", "in", "the", "present", "study", ",", "we", "investigated", "C4282122#ent", "<e1>", "polymorphisms", "in", "the", "prevalence", "of", "C0010054#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C4282122", "name": "C4282122#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [16, 17]}}
{"token": ["Stimulation", "of", "C0812329#ent", "<e1>", "e.g.", "Lyn", ",", "Lck", ",", "C1335892#ent", "<e2>", ",", "ZAP-70", ",", "Fyn", ",", "Btk", ",", "Itk", ")", "is", "the", "earliest", "detectable", "signaling", "response", "antigen-induced", "immunoreceptor", "activation", "in", "inflammatory", "cells"], "h": {"id": "C0812329", "name": "C0812329#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335892", "name": "C1335892#ent", "pos": [9, 10]}}
{"token": ["However", ",", "the", "63", "children", "without", "a", "fracture", "also", "included", "18", "(", "29", "%", ")", "who", "had", "C1837657#ent", "<e1>", "and", "11", "(", "17", "%", ")", "who", "had", "C3888065#ent", "<e2>", "."], "h": {"id": "C1837657", "name": "C1837657#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3888065", "name": "C3888065#ent", "pos": [27, 28]}}
{"token": ["Glutamate", ",", "the", "major", "excitatory", "C0243051#ent", "<e1>", "of", "the", "brain", ",", "mediates", "neuronal", "injury", "C0752308#ent", "<e2>", ",", "hypoglycemia", ",", "and", "status", "epilepticus"], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0752308", "name": "C0752308#ent", "pos": [14, 15]}}
{"token": ["We", "have", "explored", "these", "possibilities", "in", "seven", "families", "in", "whom", "C0221002#ent", "<e1>", "as", "the", "sole", "C0014130#ent", "<e2>", "."], "h": {"id": "C0221002", "name": "C0221002#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [15, 16]}}
{"token": ["C0156147#ent", "<e1>", "been", "documented", "in", "several", "families", "with", "the", "C0242994#ent", "<e2>", "."], "h": {"id": "C0156147", "name": "C0156147#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242994", "name": "C0242994#ent", "pos": [9, 10]}}
{"token": ["In", "this", "age", "group", "parental", "report", "C2926735#ent", "<e1>", "of", "OME", ",", "history", "of", "C0271429#ent", "<e2>", "parental", "smoking", "pars", "tensa", "retractions", "were", "not", "significant", "factors", "for", "persistence", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0271429", "name": "C0271429#ent", "pos": [13, 14]}}
{"token": ["Some", "human", "C0017601#ent", "<e1>", "are", "associated", "with", "anterior", "segment", "abnormalities", "as", "C0017612#ent", "<e2>", "PDS", ")", "and", "iris", "atrophy", "associated", "synechiae", "."], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [2, 3]}, "relation": "nichd_parent_of", "t": {"id": "C0017612", "name": "C0017612#ent", "pos": [11, 12]}}
{"token": ["Two", "related", "integral", "membrane", "Complex", "II", "superfamily", "members", "catalyze", "these", "reactions", ",", "succinate", ":", "C0171406#ent", "<e1>", "SQR", ")", "and", "C0220833#ent", "<e2>", ":", "menaquinol", "oxidoreductase", "QFR", ")", "."], "h": {"id": "C0171406", "name": "C0171406#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0220833", "name": "C0220833#ent", "pos": [19, 20]}}
{"token": ["During", "the", "post-initiation", "phase", "aspirin", ",", "C0006698#ent", "<e1>", "ketoprofen", ",", "piroxicam", ",", "9-cis-retinoic", "acid", "retinol", "and", "C0035976#ent", "<e2>", "inhibited", "the", "outgrowth", "of", "ACF", "into", "multiple", "crypt", "clusters", "."], "h": {"id": "C0006698", "name": "C0006698#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0035976", "name": "C0035976#ent", "pos": [16, 17]}}
{"token": ["Repression", "of", "C1418768#ent", "<e1>", "expression", "and", "recruitment", "of", "C1427862#ent", "<e2>", "are", "maintained", "in", "de", "novo", "methylation-deficient", "ES", "cells", "(", "Dnmt3A/3B-null", "cells", ")", ",", "while", "MBD2", "recruitment", "is", "lost", "."], "h": {"id": "C1418768", "name": "C1418768#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1427862", "name": "C1427862#ent", "pos": [8, 9]}}
{"token": ["Amitriptyline", "in", "combination", "with", "C0001975#ent", "<e1>", "increased", "cumulative", "choice", "reaction", "times", ",", "and", "C0013085#ent", "<e2>", "in", "combination", "with", "C0001975#ent", "<e1>", "increased", "both", "cumulative", "choice", "reaction", "times", "and", "inaccuracy", "of", "reactions", "."], "h": {"id": "C0013085", "name": "C0013085#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [4, 5]}}
{"token": ["Vinorine", "synthase", "EC", "2.3.1.160", ")", "catalyses", "the", "acetyl-CoA-", "or", "CoA-dependent", "reversible", "formation", "of", "the", "C0042672#ent", "<e1>", "or", "11-methoxy-vinorine", ")", "and", "16-epi-vellosimine", "(", "or", "C0085166#ent", "<e2>", ")", "."], "h": {"id": "C0042672", "name": "C0042672#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0085166", "name": "C0085166#ent", "pos": [23, 24]}}
{"token": ["Tetradecanoylphorbol", "13-acetate", "C0078956#ent", "<e1>", ")", "induced", "irreversible", "translocation", "of", "DGKgamma", ",", "but", "not", "C1414029#ent", "<e2>", ",", "from", "the", "cytoplasm", "to", "the", "plasma", "membrane"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414029", "name": "C1414029#ent", "pos": [13, 14]}}
{"token": ["The", "occurrence", "of", "a", "transient", "C0454543#ent", "<e1>", "a", "male", "C0003620#ent", "<e2>", "patient", "is", "described", "."], "h": {"id": "C0454543", "name": "C0454543#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003620", "name": "C0003620#ent", "pos": [9, 10]}}
{"token": ["We", "have", "characterized", "a", "homologous", "recombination", "event", "between", "two", "neighboring", "LINE-1", "sequences", "the", "human", "C0079429#ent", "<e1>", "encoding", "the", "beta", "subunit", "C0031713#ent", "<e2>", "PHKB", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0031713", "name": "C0031713#ent", "pos": [20, 21]}}
{"token": ["It", "has", "been", "demonstrated", "that", "the", "actin-severing", "activity", "C1413355#ent", "<e1>", "can", "be", "downregulated", "by", "C0294209#ent", "<e2>", "phosphorylation", "at", "residue", "Ser3", "."], "h": {"id": "C1413355", "name": "C1413355#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0294209", "name": "C0294209#ent", "pos": [14, 15]}}
{"token": ["Antagonists", "of", "dopamine", "receptors", "benzamides", ",", "phenotiazines", ",", "butyrophenones", "and", "C0013015#ent", "<e1>", ")", "induce", "adverse", "reactions", "CNS", "(", "mainly", "C0015371#ent", "<e2>", ",", "which", "are", "scarce", "with", "metoclopramide", "and", "practically", "absent", "with", "C0013015#ent", "<e1>", "."], "h": {"id": "C0013015", "name": "C0013015#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0015371", "name": "C0015371#ent", "pos": [19, 20]}}
{"token": ["The", "iron-binding", "protein", "lactoferrin", "is", "a", "C1415740#ent", "<e1>", "has", "antibacterial", ",", "antifungal", ",", "C0003451#ent", "<e2>", ",", "antitumour", ",", "anti-inflammatory", ",", "and", "immunoregulatory", "properties"], "h": {"id": "C1415740", "name": "C1415740#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [13, 14]}}
{"token": ["This", "paper", "will", "review", "the", "management", "of", "some", "of", "the", "more", "common", "diseases", "including", "C0311389#ent", "<e1>", ",", "vaginitis", ",", "cervicitis", ",", "herpes", ",", "genital", "warts", "C0026393#ent", "<e2>"], "h": {"id": "C0311389", "name": "C0311389#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0026393", "name": "C0026393#ent", "pos": [25, 26]}}
{"token": ["These", "data", "suggest", "that", "EDCs", "may", "affect", "endocrine", "functions", "C2712370#ent", "<e1>", "steroid", "hormone", "metabolism", "through", "C1417826#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417826", "name": "C1417826#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "we", "discuss", "the", "nature", "of", "these", "modifications", ",", "the", "C3540790#ent", "<e1>", "that", "bring", "them", "about", ",", "and", "how", "changes", "in", "C1705526#ent", "<e2>", "modification", "lead", "to", "C1705526#ent", "<e2>", "activation", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [22, 23]}}
{"token": ["Complex", "3D", "molecular", "models", "used", "to", "visualize", "new", "insights", "in", "the", "active", "site", "of", "cytochrome", "P450", "C3540790#ent", "<e1>", "and", "in", "the", "C1705526#ent", "<e2>", "protein-DNA", "binding", "by", "the", "use", "of", "computational", "methods"], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [21, 22]}}
{"token": ["C0042523#ent", "<e1>", "inhibits", "glucose-induced", "insulin", "release", "by", "the", "isolated", "perfused", "rat", "C0771711#ent", "<e2>", "."], "h": {"id": "C0042523", "name": "C0042523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [11, 12]}}
{"token": ["IL-8", ",", "C1334125#ent", "<e1>", "and", "CXCR2", "messenger", "RNA", "mRNA", ")", "expression", "in", "C1704969#ent", "<e2>", "upregulated", "in", "response", "to", "hypoxia", "in", "a", "time-dependent", "manner", "."], "h": {"id": "C1334125", "name": "C1334125#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704969", "name": "C1704969#ent", "pos": [12, 13]}}
{"token": ["As", "observed", "with", "C1858114#ent", "<e1>", "artificially", "enriched", "with", "apoAII", ",", "C1413353#ent", "<e2>", "significantly", "lower", "with", "plasma", "HDL3-AIAII", "than", "with", "plasma", "HDL3-AI", "particles", "."], "h": {"id": "C1858114", "name": "C1858114#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413353", "name": "C1413353#ent", "pos": [10, 11]}}
{"token": ["C0342276#ent", "<e1>", "the", "young", "(", "MODY", ")", "is", "a", "human", "C0567439#ent", "<e2>", "commonly", "due", "to", "mutations", "in", "hepatocyte", "nuclear", "factor-1alpha", "HNF-1alpha", ")", "."], "h": {"id": "C0342276", "name": "C0342276#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0567439", "name": "C0567439#ent", "pos": [10, 11]}}
{"token": ["To", "quantitate", "the", "relative", "contributions", "of", "rib", "cage", "abdomen", "to", "the", "hyperinflation", "of", "asthma", ",", "we", "examined", "C0008035#ent", "<e1>", "movements", "during", "histamine-induced", "bronchospasm", "7", "male", "C0004096#ent", "<e2>", "subjects", "."], "h": {"id": "C0008035", "name": "C0008035#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [25, 26]}}
{"token": ["These", "act", "by", "CD95L", "or", "granule", "cytotoxins", "such", "as", "C1567160#ent", "<e1>", "GrB", ")", "whose", "only", "known", "inhibitor", "is", "C1418549#ent", "<e2>", "PI-9", ")", "."], "h": {"id": "C1567160", "name": "C1567160#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1418549", "name": "C1418549#ent", "pos": [18, 19]}}
{"token": ["We", "found", "that", "all", "C1418733#ent", "<e1>", "carry", "mutations", "in", "their", "C1570559#ent", "<e2>"], "h": {"id": "C1418733", "name": "C1418733#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1570559", "name": "C1570559#ent", "pos": [10, 11]}}
{"token": ["Additionally", ",", "leaf", "C1337091#ent", "<e1>", "emissions", "were", "highest", "in", "the", "morning", ",", "when", "C0524928#ent", "<e2>", "pools", "are", "low", ",", "suggesting", "a", "link", "between", "contaminant", "metabolism", "leaf", "C0524928#ent", "<e2>", "utilization", "."], "h": {"id": "C1337091", "name": "C1337091#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [13, 14]}}
{"token": ["Annexins", "and", "C0033640#ent", "<e1>", "to", "two", "distinct", "families", "of", "ubiquitous", "C1333199#ent", "<e2>", "in", "signal", "transduction"], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333199", "name": "C1333199#ent", "pos": [10, 11]}}
{"token": ["C0053622#ent", "<e1>", "phloretin", "stimulated", ",", "whereas", "C0066801#ent", "<e2>", "and", "silymarin", "inhibited", "P-gp", "ATPase", "activity", "confirming", "that", "these", "flavonoids", "interact", "with", "P-gp", "."], "h": {"id": "C0053622", "name": "C0053622#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0066801", "name": "C0066801#ent", "pos": [6, 7]}}
{"token": ["To", "investigate", "the", "role", "of", "the", "endogenous", "urocortin", "C0030956#ent", "<e1>", "in", "heart", "failure", "HF", ")", "through", "blockade", "of", "the", "corticotropin-releasing", "factor", "receptor", "2", "C1413709#ent", "<e2>", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413709", "name": "C1413709#ent", "pos": [23, 24]}}
{"token": ["C0991617#ent", "<e1>", "in", "the", "quinolone", ",", "C3536763#ent", "<e2>", ",", "and", "tetracycline", "categories", "should", "be", "avoided", "unless", "maternal", "necessity", "for", "their", "use", "justifies", "the", "exposure", "of", "the", "fetus", "to", "their", "toxicity", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3536763", "name": "C3536763#ent", "pos": [6, 7]}}
{"token": ["Murine", "C0409974#ent", "<e1>", "is", "characterized", "by", "the", "production", "of", "numerous", "autoantibodies", "and", "C0017658#ent", "<e2>"], "h": {"id": "C0409974", "name": "C0409974#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017658", "name": "C0017658#ent", "pos": [12, 13]}}
{"token": ["Four", "vinca", "alkaloids", "in", "cancer", "therapy", "C2700251#ent", "<e1>", "were", "studied", "using", "C1565427#ent", "<e2>"], "h": {"id": "C2700251", "name": "C2700251#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1565427", "name": "C1565427#ent", "pos": [11, 12]}}
{"token": ["The", "decrease", "of", "AT", "may", "be", "caused", "by", "thrombin", "generation", "inflammatory", "reaction", "occurs", "in", "DIC", "associated", "with", "C0029896#ent", "<e1>", ",", "while", "the", "decrease", "of", "C3810551#ent", "<e2>", "might", "be", "caused", "by", "both", "thrombin", "generation", "inflammatory", "reaction"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3810551", "name": "C3810551#ent", "pos": [24, 25]}}
{"token": ["However", ",", "estimates", "of", "C1839259#ent", "<e1>", "are", "fundamentally", "similar", "for", "C3890010#ent", "<e2>", "from", "the", "Antarctic", "and", "temperate", "zone", "species", "examined", "at", "their", "native", "physiological", "temperature", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890010", "name": "C3890010#ent", "pos": [10, 11]}}
{"token": ["Pimozide", ",", "a", "C0001645#ent", "<e1>", "of", "dopamine", "receptors", "prevented", "the", "inhibitory", "effects", "seen", "following", "C0237406#ent", "<e2>", "."], "h": {"id": "C0001645", "name": "C0001645#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0237406", "name": "C0237406#ent", "pos": [14, 15]}}
{"token": ["Combination", "B", "a", "malaria", "vaccine", "that", "comprises", "recombinant", "Plasmodium", "falciparum", "P.", "falciparum", "blood-stage", "proteins", "MSP1", ",", "MSP2", "and", "C1704805#ent", "<e1>", ",", "formulated", "with", "the", "adjuvant", "C1311732#ent", "<e2>", "."], "h": {"id": "C1704805", "name": "C1704805#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1311732", "name": "C1311732#ent", "pos": [25, 26]}}
{"token": ["After", "removal", "of", "11", "C3539946#ent", "<e1>", "the", "C-terminus", "the", "residue", "peptide", "was", "a", "full", "C0243192#ent", "<e2>", "although", "higher", "concentrations", "were", "necessary", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [14, 15]}}
{"token": ["However", ",", "it", "is", "not", "known", "whether", "the", "short-term", "administration", "of", "G-CSF", "or", "C1332791#ent", "<e1>", "exerts", "beneficial", "effects", "on", "C0004153#ent", "<e2>", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [19, 20]}}
{"token": ["To", "compare", "the", "C0040349#ent", "<e1>", "the", "side", "effects", "nicardipine", "to", "those", "of", "C0543495#ent", "<e2>", "in", "patients", "presenting", "premature", "labor", "order", "to", "propose", "nicardipine", "as", "a", "promising", "alternative", "to", "C0543495#ent", "<e2>", "in", "the", "treatment", "of", "premature", "labor"], "h": {"id": "C0040349", "name": "C0040349#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0543495", "name": "C0543495#ent", "pos": [12, 13]}}
{"token": ["Although", "ablation", "of", "C2982484#ent", "<e1>", "in", "C1447747#ent", "<e2>", "did", "not", "affect", "normoxic", "glycogen", "levels", "restoration", "of", "C2982484#ent", "<e1>", "to", "C1447747#ent", "<e2>", "led", "to", "an", "increase", "in", "glycogen", "under", "hypoxic", "conditions", "."], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [3, 4]}}
{"token": ["Renal", "tubular", "function", "studied", "in", "an", "8-month-old", "male", "infant", "with", "Bartter's", "syndrome", "which", "is", "characterized", "by", "hypokalemic", "metabolic", "alkalosis", "normotensive", "C0342483#ent", "<e1>", "and", "reduced", "C0237795#ent", "<e2>", "response", "to", "angiotensin", "II"], "h": {"id": "C0342483", "name": "C0342483#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0237795", "name": "C0237795#ent", "pos": [24, 25]}}
{"token": ["DNA", "sequence", "analysis", "each", "individual", "inserted", "cDNAs", "revealed", "that", ">", "60", "%", "contained", "the", "full-length", "C0079941#ent", "<e1>", "many", "genes", "including", "cytokine", "receptors", "cytoplasmic", "proteins", "C1449702#ent", "<e2>", "and", "nuclear", "factors"], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1449702", "name": "C1449702#ent", "pos": [24, 25]}}
{"token": ["The", "second", "patient", "presented", "with", "quadriplegia", ",", "C0001127#ent", "<e1>", "had", "no", "signs", "symptoms", "of", "C0040156#ent", "<e2>", "."], "h": {"id": "C0001127", "name": "C0001127#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0040156", "name": "C0040156#ent", "pos": [14, 15]}}
{"token": ["Five", "significant", "photodegradation", "products", "were", "observed", "and", "a", "high-performance", "liquid", "chromatography", "HPLC", ")", "assay", "was", "employed", "to", "C1875400#ent", "<e1>", "them", "from", "C0594375#ent", "<e2>", "using", "gradient", "conditions", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [21, 22]}}
{"token": ["The", "etiology", "of", "C0026265#ent", "<e1>", ":", "previous", "rheumatic", "fever", "69", "cases", ")", "and", "C0155685#ent", "<e2>", "1", "case", ")", ";", "there", "were", "3", "cases", "of", "periprosthetic", "leak", "."], "h": {"id": "C0026265", "name": "C0026265#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0155685", "name": "C0155685#ent", "pos": [13, 14]}}
{"token": ["The", "etiology", "of", "C0026265#ent", "<e1>", "rheumatic", "in", "46", ",", "congenital", "in", "eight", ",", "and", "C0155685#ent", "<e2>", "two", "."], "h": {"id": "C0026265", "name": "C0026265#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0155685", "name": "C0155685#ent", "pos": [14, 15]}}
{"token": ["Development", "of", "C0001175#ent", "<e1>", "AIDS", ")", "or", "AIDS-related", "complex", "strongly", "associated", "with", "evidence", "of", "persistent", "C3539699#ent", "<e2>", "antigenemia", "during", "the", "early", ",", "postseroconversion", "period", "."], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [15, 16]}}
{"token": ["On", "the", "basis", "of", "these", "observations", ",", "we", "propose", "a", "model", "for", "the", "mechanism", "of", "cell-cell", "adhesion", "C1419142#ent", "<e1>", "and", "roles", "of", "C1706479#ent", "<e2>", "in", "this", "mechanism", "."], "h": {"id": "C1419142", "name": "C1419142#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1706479", "name": "C1706479#ent", "pos": [22, 23]}}
{"token": ["Susceptibility", "to", "C0042510#ent", "<e1>", "may", "be", "predicted", "by", "the", "C1415876#ent", "<e2>", "or", "RTcd", "in", "BS", "."], "h": {"id": "C0042510", "name": "C0042510#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415876", "name": "C1415876#ent", "pos": [9, 10]}}
{"token": ["Limited", "data", "that", "patients", "with", "C0009806#ent", "<e1>", "to", "underlying", "motility", "disorders", "benefit", "from", "C0072916#ent", "<e2>", "."], "h": {"id": "C0009806", "name": "C0009806#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0072916", "name": "C0072916#ent", "pos": [13, 14]}}
{"token": ["However", ",", "NGF", "stimulation", "caused", "transient", "activation", "of", "classical", "C0080058#ent", "<e1>", "sustained", "activation", "of", "C1367476#ent", "<e2>", "as", "well", "as", "sustained", "activating", "phosphorylation", "of", "ERK", "and", "CREB", "."], "h": {"id": "C0080058", "name": "C0080058#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367476", "name": "C1367476#ent", "pos": [14, 15]}}
{"token": ["On", "the", "other", "hand", ",", "IFCC", "recommends", "the", "measurement", "of", "both", "C0282109#ent", "<e1>", "and", "apoenzymes", "when", "C3812647#ent", "<e2>", "is", "added", ",", "reflecting", "the", "total", "diverted", "from", "the", "internal", "organs"], "h": {"id": "C0282109", "name": "C0282109#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3812647", "name": "C3812647#ent", "pos": [16, 17]}}
{"token": ["The", "inner", "cortex", "to", "ACTH", "with", "increased", "C1258847#ent", "<e1>", "activity", ",", "but", "was", "little", "affected", "by", "C0011816#ent", "<e2>", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011816", "name": "C0011816#ent", "pos": [16, 17]}}
{"token": ["C0033216#ent", "<e1>", "and", "hydralazine", "are", "drugs", "that", "cause", "C0024131#ent", "<e2>", "in", "genetically", "predisposed", "individuals", "."], "h": {"id": "C0033216", "name": "C0033216#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024131", "name": "C0024131#ent", "pos": [8, 9]}}
{"token": ["The", "presence", "of", "this", "domain", "raises", "the", "intriguing", "possibility", "that", "C3273689#ent", "<e1>", "may", "interact", "with", "a", "C2362546#ent", "<e2>", "providing", "a", "link", "between", "the", "signaling", "machinery", "the", "plasma", "membrane", "the", "downstream", "kinase"], "h": {"id": "C3273689", "name": "C3273689#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2362546", "name": "C2362546#ent", "pos": [16, 17]}}
{"token": ["Treatment", "of", "rats", "with", "C0752375#ent", "<e1>", "an", "inhibitor", "of", "C1412100#ent", "<e2>", "causes", "a", "decrease", "in", "the", "excretion", "of", "N-(3-aminopropyl)pyrrolidin-2-one", "and", "its", "derivatives", "."], "h": {"id": "C0752375", "name": "C0752375#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412100", "name": "C1412100#ent", "pos": [9, 10]}}
{"token": ["Fibrinogen", "binding", "alpha(IIb)beta3", "stimulated", "the", "association", "of", "PKCtheta", "with", "tyrosine", "kinases", "C1528376#ent", "<e1>", "and", "Syk", ",", "and", "tyrosine", "phosphorylation", "PKCtheta", ",", "C1528376#ent", "<e1>", "and", "the", "actin", "regulator", "Wiskott-Aldrich", "syndrome", "protein", "C1705616#ent", "<e1>", ")", "."], "h": {"id": "C1528376", "name": "C1528376#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705616", "name": "C1705616#ent", "pos": [30, 31]}}
{"token": ["In", "three", "patients", "with", "either", "hypertension", "or", "C0034734#ent", "<e1>", "phenomenon", "who", "were", "treated", "with", "types", "of", "vasodilatory", "drugs", "i.e.", "C0032912#ent", "<e2>", ",", "nifedipine", "and", "prostacyclin", ",", "a", "decrease", "in", "rectal", "body", "temperature", "measured", "."], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0032912", "name": "C0032912#ent", "pos": [19, 20]}}
{"token": ["Microglia", "stimulated", "with", "C2350558#ent", "<e1>", "murine", "immunoglobulin", "also", "produced", "MIP-1alpha", "and", "C1332691#ent", "<e2>", "(", "MIP-1alpha", ">", "C1332691#ent", "<e2>", ")", "."], "h": {"id": "C2350558", "name": "C2350558#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1332691", "name": "C1332691#ent", "pos": [11, 12]}}
{"token": ["Rumination", "is", "an", "unusual", "C0426576#ent", "<e1>", "is", "characterized", "by", "the", "C2004489#ent", "<e2>", "gastric", "contents", "into", "the", "oropharynx", "."], "h": {"id": "C0426576", "name": "C0426576#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2004489", "name": "C2004489#ent", "pos": [10, 11]}}
{"token": ["In", "progressive", "C1290138#ent", "<e1>", "a", "disease", "of", "C0029166#ent", "<e2>", "involvement", "of", "the", "gastrointestinal", "tract", "noted", "infrequently", "in", "patients", "who", "are", "asymptomatic", ",", "and", "is", "rarely", "fatal", "."], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [7, 8]}}
{"token": ["C1290138#ent", "<e1>", "SSc", ")", "is", "an", "autoimmune", "disorder", "a", "high", "mortality", "rate", "C0029166#ent", "<e2>", "such", "as", "interstitial", "lung", "disease", "pulmonary", "hypertension", "seen", "at", "autopsy", "in", "90", "%", "and", "75", "%", "of", "patients", ",", "respectively", "."], "h": {"id": "C1290138", "name": "C1290138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [12, 13]}}
{"token": ["For", "premenopausal", "women", ",", "ovarian", "function", "suppression", "with", "luteinizing", "hormone-releasing", "hormone", "analogues", "combined", "with", "C0039286#ent", "<e1>", "has", "generated", "similar", "results", "to", "C0010583#ent", "<e2>", ",", "methotrexate", ",", "5-fluorouracil", "(CMF)-based", "regimens", "."], "h": {"id": "C0039286", "name": "C0039286#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [21, 22]}}
{"token": ["The", "ABO", "blood", "group", "locus", "the", "Surfeit", "gene", "cluster", ",", "the", "C0013032#ent", "<e1>", "DBH", ")", "and", "VAV2", ",", "a", "homologue", "of", "the", "C1336926#ent", "<e2>", "have", "all", "been", "mapped", "within", "the", "contigs", "."], "h": {"id": "C0013032", "name": "C0013032#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1336926", "name": "C1336926#ent", "pos": [22, 23]}}
{"token": ["C0006931#ent", "<e1>", "or", "vehicle", "cream", "was", "applied", "to", "C0030193#ent", "<e2>", "times", "per", "day", "for", "8", "weeks", "in", "patients", "randomly", "assigned", "to", "one", "of", "two", "groups", "."], "h": {"id": "C0006931", "name": "C0006931#ent", "pos": [0, 1]}, "relation": "may_prevent", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [8, 9]}}
{"token": ["C0221002#ent", "<e1>", "states", "85", "%", "percent", "of", "all", "kinds", "of", "C1840402#ent", "<e2>", "is", "usually", "parathyroid", "adenoma", "in", "11", "-", "15", "%", "glandular", "hyperplasia", "in", "1", "-", "4", "%", "parathyroid", "cancer"], "h": {"id": "C0221002", "name": "C0221002#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [10, 11]}}
{"token": ["Zollinger-Ellison", "syndrome", "patients", "with", "MEN-1", "and", "C0221002#ent", "<e1>", "best", "managed", "initially", "by", "surgery", "directed", "at", "the", "C1840402#ent", "<e2>", "."], "h": {"id": "C0221002", "name": "C0221002#ent", "pos": [6, 7]}, "relation": "manifestation_of", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [16, 17]}}
{"token": ["C0029076#ent", "<e1>", "a", "form", "of", "C0009763#ent", "<e2>", "occurring", "in", "infants", "younger", "than", "4", "weeks", "."], "h": {"id": "C0029076", "name": "C0029076#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0009763", "name": "C0009763#ent", "pos": [5, 6]}}
{"token": ["C1417664#ent", "<e1>", "(", "human", "enhancer", "of", "C2348445#ent", "<e2>", "is", "a", "member", "of", "a", "docking", "protein", "family", "includes", "p130(Cas", ")", "and", "Efs", "."], "h": {"id": "C1417664", "name": "C1417664#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2348445", "name": "C2348445#ent", "pos": [6, 7]}}
{"token": ["In", "response", "to", "C0240066#ent", "<e1>", "Arabidopsis", "roots", "induce", "the", "expression", "of", "the", "divalent", "cation", "transporter", "C1412299#ent", "<e2>", "."], "h": {"id": "C0240066", "name": "C0240066#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412299", "name": "C1412299#ent", "pos": [15, 16]}}
{"token": ["This", "is", "the", "first", "association", "analysis", "polymorphisms", "within", "the", "C1417760#ent", "<e1>", "extended", "gene", "with", "C0021390#ent", "<e2>", "susceptibility", "."], "h": {"id": "C1417760", "name": "C1417760#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [14, 15]}}
{"token": ["Terminally", "ill", "cancer", "patients", "with", "complicated", "bowel", "obstructions", "have", "poor", "quality", "of", "life", "C0518214#ent", "<e1>", ")", "due", "to", "C0426576#ent", "<e2>", "as", "nausea", "and", "vomiting", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0426576", "name": "C0426576#ent", "pos": [18, 19]}}
{"token": ["We", "here", "demonstrate", "that", "C1412323#ent", "<e1>", "also", "acts", "as", "a", "C0002003#ent", "<e2>", "in", "vivo"], "h": {"id": "C1412323", "name": "C1412323#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002003", "name": "C0002003#ent", "pos": [10, 11]}}
{"token": ["Moreover", ",", "we", "identified", "deregulated", "genes", "both", "the", "retinoic", "acid", "the", "C0525678#ent", "<e1>", "pathways", ",", "such", "as", "ATX/ENPP2", "and", "C1823422#ent", "<e2>", ",", "suggesting", "an", "association", "between", "these", "two", "pathways", "with", "that", "of", "WNT", "."], "h": {"id": "C0525678", "name": "C0525678#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1823422", "name": "C1823422#ent", "pos": [19, 20]}}
{"token": ["C0170168#ent", "<e1>", "known", "to", "be", "activated", "by", "reactive", "oxygen", "species", "C0289313#ent", "<e2>", ")", ",", "such", "as", "H2O2", ",", "in", "several", "cell", "types"], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0289313", "name": "C0289313#ent", "pos": [10, 11]}}
{"token": ["The", "challenge", "facing", "clinicians", "is", "to", "determine", "whether", "these", "respiratory", "symptoms", "due", "to", "an", "C0029118#ent", "<e1>", "to", "a", "chronic", "process", "such", "as", "asthma", ",", "C0008677#ent", "<e2>", "bronchiectasis", ",", "or", "emphysema", "."], "h": {"id": "C0029118", "name": "C0029118#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0008677", "name": "C0008677#ent", "pos": [24, 25]}}
{"token": ["Wegener's", "granulomatosis", "WG", ")", "is", "characterized", "by", "C0018202#ent", "<e1>", "renal", "disease", "and", "upper", "and", "lower", "C0035204#ent", "<e2>"], "h": {"id": "C0018202", "name": "C0018202#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [15, 16]}}
{"token": ["The", "relationship", "between", "C0919427#ent", "<e1>", "(", "C677", "T", ")", "genotypes", "of", "the", "C0066357#ent", "<e2>", "bone", "mineral", "density", "BMD", ")", ",", "and", "vertebral", "fracture", "studied", "in", "657", "Chinese", "men", "and", "women", "."], "h": {"id": "C0919427", "name": "C0919427#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0066357", "name": "C0066357#ent", "pos": [12, 13]}}
{"token": ["C0949990#ent", "<e1>", "UNC-18", "protein", "homologous", "to", "yeast", "Sec1p", ",", "is", "important", "in", "C0243051#ent", "<e2>", "release", ",", "because", "the", "unc-18", "mutation", "leads", "to", "severe", "paralysis", "and", "presynaptic", "acetylcholine", "ACh", ")", "accumulation", "."], "h": {"id": "C0949990", "name": "C0949990#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [12, 13]}}
{"token": ["During", "the", "prospective", "follow-up", "three", "years", ",", "three", "asymptomatic", "boys", "with", "C0155765#ent", "<e1>", "have", "experienced", "C0917796#ent", "<e2>"], "h": {"id": "C0155765", "name": "C0155765#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0917796", "name": "C0917796#ent", "pos": [15, 16]}}
{"token": ["C2936331#ent", "<e1>", "are", "a", "group", "of", "congenital", "muscular", "dystrophies", "CMDs", ")", "with", "C3899988#ent", "<e2>", "inheritance", ",", "often", "associated", "with", "CNS", "and", "ocular", "involvement", "."], "h": {"id": "C2936331", "name": "C2936331#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3899988", "name": "C3899988#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "whereas", "TGF-beta", "induced", "C1421244#ent", "<e1>", "in", "mature", "chondrocytes", ",", "it", "inhibited", "C1419771#ent", "<e2>", "expression", "in", "these", "cells", "."], "h": {"id": "C1421244", "name": "C1421244#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [13, 14]}}
{"token": ["Early", "recognition", "ectrodactyly", ",", "ectodermal", "dysplasia", "and", "clefting", "of", "the", "C3889123#ent", "<e1>", "and", "palate", "as", "a", "C1848862#ent", "<e2>", "could", "result", "in", "more", "beneficial", "treatment", "for", "the", "patient", "."], "h": {"id": "C3889123", "name": "C3889123#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "a", "pharmacologically", "induced", "enhancement", "of", "C0242893#ent", "<e1>", "in", "an", "increase", "in", "C1335796#ent", "<e2>", ",", "whereas", "muscarinic", "receptor", "blockade", "had", "no", "effect", "C1335796#ent", "<e2>", "levels", "or", "blood", "pressure"], "h": {"id": "C0242893", "name": "C0242893#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335796", "name": "C1335796#ent", "pos": [14, 15]}}
{"token": ["In", "yeast", "cells", "C1D", "binds", "to", "C0669365#ent", "<e1>", "activated", "but", "not", "to", "GDP-bound", "C1705553#ent", "<e2>", "."], "h": {"id": "C0669365", "name": "C0669365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705553", "name": "C1705553#ent", "pos": [13, 14]}}
{"token": ["Aminopyridines", "have", "been", "used", "as", "beneficial", "symptomatic", "treatments", "in", "a", "variety", "of", "neurological", "conditions", "multiple", "sclerosis", "have", "been", "associated", "with", "toxicity", "in", "the", "form", "of", "C0000737#ent", "<e1>", "paraesthesias", "and", "(", "rarely", ")", "C0036572#ent", "<e2>", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [32, 33]}}
{"token": ["Acute", "porphyrias", "with", "severe", "C0000737#ent", "<e1>", "confusion", "and", "C0036572#ent", "<e2>", "which", "may", "be", "life-threatening", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}}
{"token": ["The", "xylazine-induced", "vomiting", "was", "antagonized", "by", "C2936568#ent", "<e1>", "alpha", "2-blocking", "activity", ",", "which", "were", "yohimbine", ",", "C0040373#ent", "<e2>", ",", "and", "phentolamine", "."], "h": {"id": "C2936568", "name": "C2936568#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040373", "name": "C0040373#ent", "pos": [16, 17]}}
{"token": ["Eight", "cases", "of", "symptomatic", "C3489393#ent", "<e1>", "investigated", ";", "four", "presented", "with", "C0037090#ent", "<e2>", "chronic", "asthmatic", "bronchitis", "bronchopneumonia", "."], "h": {"id": "C3489393", "name": "C3489393#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037090", "name": "C0037090#ent", "pos": [11, 12]}}
{"token": ["The", "recognition", "that", "inflammation", "is", "closely", "related", "to", "atherothrombosis", ",", "C0011849#ent", "<e1>", ",", "and", "the", "C0524620#ent", "<e2>", "represents", "an", "enormously", "important", "advance", "in", "medical", "science"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}, "relation": "related_to", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [15, 16]}}
{"token": ["We", "identified", "81", "children", "with", "NTM", ",", "14", "with", "C0041330#ent", "<e1>", "and", "192", "with", "C0024205#ent", "<e2>"], "h": {"id": "C0041330", "name": "C0041330#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024205", "name": "C0024205#ent", "pos": [14, 15]}}
{"token": ["Our", "results", "support", "the", "hypothesis", "that", "tissue-derived", "C0623362#ent", "<e1>", "may", "be", "involved", "in", "tissue", "remodelling", "C0017563#ent", "<e2>", "conclusively", "demonstrate", "that", "epithelial", "cells", "be", "involved", "as", "well", "as", "connective", "tissue", "cells"], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017563", "name": "C0017563#ent", "pos": [15, 16]}}
{"token": ["It", "also", "has", "a", "role", "where", "the", "endoscopy", "findings", "are", "normal", "and", "in", "patients", "with", "C3275051#ent", "<e1>", "such", "as", "chest", "pain", "asthma/cough", "or", "C0019825#ent", "<e2>", "."], "h": {"id": "C3275051", "name": "C3275051#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0019825", "name": "C0019825#ent", "pos": [23, 24]}}
{"token": ["The", "rank", "order", "of", "trans-repression", "potencies", "in", "A549", "lung", "cells", "transfected", "with", "an", "AP-1-", "or", "NF-kappaB-dependent", "luciferase", "gene", "was", "fluticasone", "propionate", "C0054201#ent", "<e1>", ">", "beclomethasone", "dipropionate", ",", "triamcinolone", "acetonide", "and", "C0060501#ent", "<e2>", "."], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0060501", "name": "C0060501#ent", "pos": [30, 31]}}
{"token": ["Propranolol", ",", "C0077158#ent", "<e1>", "or", "hexamethonium", "had", "no", "effect", "DCA", "stimulation", "of", "C0033036#ent", "<e2>", "activity", "."], "h": {"id": "C0077158", "name": "C0077158#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [12, 13]}}
{"token": ["The", "protective", "effects", "IB-MECA", "against", "stunning", "were", "completely", "blocked", "by", "pretreatment", "with", "the", "C2936569#ent", "<e1>", "theophylline", "or", "the", "specific", "C1415545#ent", "<e2>", "chelerythrine", "."], "h": {"id": "C2936569", "name": "C2936569#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415545", "name": "C1415545#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "we", "find", "that", "mouse", "embryonic", "fibroblasts", "(", "MEFs", ")", "deficient", "for", "C1423062#ent", "<e1>", ",", "a", "mammalian", "C1101544#ent", "<e2>", "have", "dramatically", "increased", "resistance", "to", "replicative", "senescence"], "h": {"id": "C1423062", "name": "C1423062#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1101544", "name": "C1101544#ent", "pos": [19, 20]}}
{"token": ["Severe", "C0034103#ent", "<e1>", "resulting", "from", "C0011334#ent", "<e2>", "characterized", "by", "marked", "inflammatory", "infiltrate", "as", "lymphocytes", "."], "h": {"id": "C0034103", "name": "C0034103#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011334", "name": "C0011334#ent", "pos": [5, 6]}}
{"token": ["The", "increased", "C1332102#ent", "<e1>", "in", "patients", "with", "C0271725#ent", "<e2>", "to", "an", "increased", "disorderliness", "of", "ACTH", "and", "cortisol", "secretion", "with", "healthy", "controls"], "h": {"id": "C1332102", "name": "C1332102#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0271725", "name": "C0271725#ent", "pos": [7, 8]}}
{"token": ["Metaproterenol", "and", "salbutamol", "in", "the", "presence", "of", "1", "MAC", "halothane", "anaesthesia", "methacholine-induced", "C0006266#ent", "<e1>", "more", "rapidly", "than", "did", "C0022176#ent", "<e2>", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [12, 13]}, "relation": "may_be_treated_by", "t": {"id": "C0022176", "name": "C0022176#ent", "pos": [18, 19]}}
{"token": ["In", "kidney", ",", "ALA", "synthetase", "C0002564#ent", "<e1>", "but", "not", "C1414580#ent", "<e2>", "were", "depressed", "in", "vivo", "32", "and", "20", "%", "of", "control", ",", "respectively", "."], "h": {"id": "C0002564", "name": "C0002564#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414580", "name": "C1414580#ent", "pos": [9, 10]}}
{"token": ["To", "investigate", "the", "pathology", "of", "osteonecrosis", "of", "the", "femoral", "head", "C2985244#ent", "<e1>", ")", "in", "patients", "with", "C0038013#ent", "<e2>", "RA", ")", ",", "we", "examined", "26", "hips", "clinically", "and", "histologically", "."], "h": {"id": "C2985244", "name": "C2985244#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [16, 17]}}
{"token": ["We", "also", "found", "that", "inhibitors", "of", "histone", "deacetylase", "as", "trichostatin", "A", "forestall", "the", "silencing", "of", "C0282641#ent", "<e1>", "suggesting", "that", "C0008546#ent", "<e2>", "mediates", "the", "silencing", "of", "transfected", "genes", "."], "h": {"id": "C0282641", "name": "C0282641#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0008546", "name": "C0008546#ent", "pos": [19, 20]}}
{"token": ["Deletion", "analysis", "that", "the", "N-terminal", "non-catalytic", "region", "of", "NtMKP1", "bound", "C1368110#ent", "<e1>", "and", "was", "essential", "for", "inactivating", "C1368110#ent", "<e1>", ",", "whereas", "the", "C1424659#ent", "<e1>", "and", "C-terminal", "domains", "dispensable", "."], "h": {"id": "C1368110", "name": "C1368110#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1424659", "name": "C1424659#ent", "pos": [22, 23]}}
{"token": ["Expression", "of", "EGFP-tagged", "TNGW1", "in", "HeLa", "cells", "colocalized", "to", "cytoplasmic", "foci", "in", "C1414333#ent", "<e1>", "(", "also", "known", "as", "C2827477#ent", "<e2>", ")", "and", "RNA", "decay", "factors", "."], "h": {"id": "C1414333", "name": "C1414333#ent", "pos": [12, 13]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2827477", "name": "C2827477#ent", "pos": [18, 19]}}
{"token": ["C1412071#ent", "<e1>", "(", "-/-", ")", "mice", "secrete", "phosphatidylcholine-free", ",", "cytotoxic", "bile", "develop", "C0267918#ent", "<e2>"], "h": {"id": "C1412071", "name": "C1412071#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0267918", "name": "C0267918#ent", "pos": [12, 13]}}
{"token": ["The", "small", "GTPase", "C1419195#ent", "<e1>", "and", "the", "C1427947#ent", "<e2>", "been", "shown", "to", "be", "required", "for", "both", "granule", "maturation", "and", "granule", "docking", "and", "priming", "at", "the", "immunologic", "synapse"], "h": {"id": "C1419195", "name": "C1419195#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1427947", "name": "C1427947#ent", "pos": [7, 8]}}
{"token": ["C1710304#ent", "<e1>", "is", "especially", "helpful", "in", "confirming", "cicatricial", "alopecia", "to", "C3542918#ent", "<e2>", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3542918", "name": "C3542918#ent", "pos": [10, 11]}}
{"token": ["These", "results", "identify", "C1825519#ent", "<e1>", "as", "a", "C1825064#ent", "<e2>", "c-Myc", "and", "suggest", "a", "novel", "role", "for", "C1825519#ent", "<e1>", "in", "regulating", "c-Myc-enhanced", "ribosomal", "biogenesis"], "h": {"id": "C1825519", "name": "C1825519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1825064", "name": "C1825064#ent", "pos": [7, 8]}}
{"token": ["In", "contrast", "to", "the", "increased", "mortality", "risk", "patients", "with", "C0751535#ent", "<e1>", "patients", "with", "C0042420#ent", "<e2>", "a", "benign", "prognosis", "."], "h": {"id": "C0751535", "name": "C0751535#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0042420", "name": "C0042420#ent", "pos": [13, 14]}}
{"token": ["Taken", "together", ",", "these", "data", "suggest", "C4055175#ent", "<e1>", "suppresses", "JAK-STAT", "signaling", "activation", "of", "C1335280#ent", "<e2>", ",", "thus", "attenuating", "inflammatory", "response", "brain", "microglial", "cells"], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335280", "name": "C1335280#ent", "pos": [13, 14]}}
{"token": ["However", ",", "differences", "in", "the", "C0002085#ent", "<e1>", "distribution", "in", "leukocyte", "and", "tumour", "C0011519#ent", "<e2>", "of", "cancer", "patients", "may", "be", "related", "to", "an", "involvement", "of", "the", "Ha-ras", "1", "gene", "tumorigenesis", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [12, 13]}}
{"token": ["Mutagenesis", "of", "CRE2", ",", "CRE3", "and", "CRE4", "blocked", "the", "stimulatory", "effect", "of", "C0061355#ent", "<e1>", "while", "mutagenesis", "of", "C1419420#ent", "<e2>", "had", "no", "effect"], "h": {"id": "C0061355", "name": "C0061355#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1419420", "name": "C1419420#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "we", "performed", "a", "prospective", "study", "compare", "the", "efficacy", "of", "combination", "therapy", "desmopressin", "and", "C0069805#ent", "<e1>", "vs", "the", "C0003290#ent", "<e2>", "imipramine", "in", "patients", "with", "attention", "deficit", "hyperactivity", "disorder", "have", "nocturnal", "enuresis"], "h": {"id": "C0069805", "name": "C0069805#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003290", "name": "C0003290#ent", "pos": [19, 20]}}
{"token": ["Limiting", "C1420884#ent", "<e1>", "expression", "by", "positive", "feedback", "the", "C1370600#ent", "<e2>", "mitogen-activated", "protein", "kinase", "pathway", "facilitate", "switching", "to", "a", "proangiogenic", "state", "low", "doses", "NO", "."], "h": {"id": "C1420884", "name": "C1420884#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [8, 9]}}
{"token": ["In", "vivo", "administration", "of", "LIF", ",", "C0279238#ent", "<e1>", ",", "IL-6", ",", "or", "SCF", ",", "but", "not", "C1524095#ent", "<e2>", ",", "i.p", "."], "h": {"id": "C0279238", "name": "C0279238#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1524095", "name": "C1524095#ent", "pos": [16, 17]}}
{"token": ["The", "breakpoint", "cluster", "region", "C0105421#ent", "<e1>", ")", "of", "the", "C0812385#ent", "<e2>", "found", "to", "be", "rearranged", "in", "these", "cells", "by", "Southern", "blot", "analysis", "a", "major", "3'-side", "bcr", "probe", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [9, 10]}}
{"token": ["Full-length", "C0105421#ent", "<e1>", "as", "well", "as", "C0812385#ent", "<e2>", "sequences", "retained", "in", "BCR-ABL", "bind", "specifically", "to", "the", "SH2", "domain", "ABL", "."], "h": {"id": "C0105421", "name": "C0105421#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812385", "name": "C0812385#ent", "pos": [6, 7]}}
{"token": ["Western", "blotting", "C1705321#ent", "<e1>", "was", "performed", "on", "C1366480#ent", "<e2>", "from", "three", "patients", "with", "rheumatoid", "arthritis", "RA", ")", "and", "primary", "inflammatory", "arthropathies"], "h": {"id": "C1705321", "name": "C1705321#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366480", "name": "C1366480#ent", "pos": [7, 8]}}
{"token": ["C0271408#ent", "<e1>", "IgG", "antibody", "levels", "to", "C1428415#ent", "<e2>", "were", "substantially", "higher", "than", "vitreous", "IgA", "antibody", "levels", "."], "h": {"id": "C0271408", "name": "C0271408#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1428415", "name": "C1428415#ent", "pos": [6, 7]}}
{"token": ["The", "presence", "in", "C1704942#ent", "<e1>", "of", "the", "Sec7", "domain", ",", "present", "in", "all", "C0120465#ent", "<e2>", "has", "suggested", "that", "recruitment", "of", "Arf", "is", "an", "early", "step", "in", "pathogenesis", "."], "h": {"id": "C1704942", "name": "C1704942#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0120465", "name": "C0120465#ent", "pos": [13, 14]}}
{"token": ["C0085535#ent", "<e1>", ",", "an", "inhibitor", "of", "C0024746#ent", "<e2>", "effected", "only", "a", "marginal", "reduction", "in", "the", "degree", "of", "fucosylation", "of", "secreted", "IRBP", "."], "h": {"id": "C0085535", "name": "C0085535#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024746", "name": "C0024746#ent", "pos": [6, 7]}}
{"token": ["The", "C0072497#ent", "<e1>", "production", "in", "tumor", "bladders", "instilled", "with", "8", "mM", "C1415465#ent", "<e2>", "was", "significantly", "higher", "than", "after", "16", "mM", "C1415465#ent", "<e2>", "."], "h": {"id": "C0072497", "name": "C0072497#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415465", "name": "C1415465#ent", "pos": [11, 12]}}
{"token": ["This", "NHA-driven", "NO", "formation", "completely", "relied", "on", "H(4)B", "and", "was", "not", "sensitive", "to", "C0669516#ent", "<e1>", "catalase", "but", "was", "inhibited", "by", "C0020923#ent", "<e2>", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020923", "name": "C0020923#ent", "pos": [20, 21]}}
{"token": ["This", "trial", "will", "enroll", "patients", "with", "symptoms", "of", "C0018802#ent", "<e1>", "depressed", "left", "ventricular", "ejection", "fraction", "randomly", "assign", "them", "to", "either", "captopril", ",", "C0216784#ent", "<e2>", ",", "or", "the", "combination", "."], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0216784", "name": "C0216784#ent", "pos": [22, 23]}}
{"token": ["The", "Tbeta4", "overexpressing", "cells", "approximately", "1.4x", "more", "C1565427#ent", "<e1>", "than", "the", "controls", ",", "and", "the", "C0031727#ent", "<e2>", "is", "approximately", "2-fold", "more", "phosphorylated", "in", "adherent", "OE", "cells", "in", "the", "vector", "controls"], "h": {"id": "C1565427", "name": "C1565427#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [15, 16]}}
{"token": ["Here", ",", "we", "draw", "analogies", "to", "monomeric", "and", "C0920283#ent", "<e1>", "propose", "that", "C0253166#ent", "<e2>", "and", "SWI/SNF", "complexes", "different", "outcomes", "in", "part", "because", "some", "C0253166#ent", "<e2>", "complexes", "function", "as", "dimers", "while", "SWI/SNF", "complexes", "function", "monomers", "."], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0253166", "name": "C0253166#ent", "pos": [12, 13]}}
{"token": ["We", "report", "here", "two", "sisters", "presenting", "with", "Holmes", "type", "cerebellar", "ataxia", "C0271623#ent", "<e1>", "retinochoroidal", "degeneration", "diagnosed", "as", "C1859093#ent", "<e2>"], "h": {"id": "C0271623", "name": "C0271623#ent", "pos": [11, 12]}, "relation": "manifestation_of", "t": {"id": "C1859093", "name": "C1859093#ent", "pos": [17, 18]}}
{"token": ["Unlike", "C3273700#ent", "<e1>", ",", "HIM-17", "is", "also", "required", "for", "proper", "accumulation", "of", "C3829685#ent", "<e2>", "methylation", "at", "lysine", "9", "meiotic", "prophase", "chromosomes"], "h": {"id": "C3273700", "name": "C3273700#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3829685", "name": "C3829685#ent", "pos": [12, 13]}}
{"token": ["With", "the", "advent", "of", "monoclonal", "antibodies", "new", "C0003209#ent", "<e1>", "prevention", "of", "progression", "from", "C0243026#ent", "<e2>", "to", "multiorgan", "failure", "become", "possible", "."], "h": {"id": "C0003209", "name": "C0003209#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [13, 14]}}
{"token": ["AKAP", "350", "was", "identified", "as", "a", "specific", "C1824717#ent", "<e1>", "demonstrated", "in", "the", "C1418374#ent", "<e2>"], "h": {"id": "C1824717", "name": "C1824717#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418374", "name": "C1418374#ent", "pos": [12, 13]}}
{"token": ["We", "suggest", "that", "C1413756#ent", "<e1>", "functions", "as", "a", "molecular", "switch", "direct", "C1414199#ent", "<e2>", "from", "the", "JNK", "pathway", "the", "beta-catenin", "pathway", "possibly", "by", "altering", "the", "conformation", "of", "the", "C", "terminus", "of", "C1414199#ent", "<e2>", "."], "h": {"id": "C1413756", "name": "C1413756#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414199", "name": "C1414199#ent", "pos": [11, 12]}}
{"token": ["Whether", "known", "C1415831#ent", "<e1>", "the", "transcription", "factor", "7-like", "2", "TCF7L2", ")", "gene", "are", "associated", "with", "chronic", "kidney", "disease", "C2974542#ent", "<e2>", ")", "progression", "and", "markers", "of", "kidney", "function", "unknown", "."], "h": {"id": "C1415831", "name": "C1415831#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2974542", "name": "C2974542#ent", "pos": [18, 19]}}
{"token": ["Newer", "C0991617#ent", "<e1>", "including", "levofloxacin", ",", "grepafloxacin", ",", "C2347728#ent", "<e2>", "and", "trovafloxacin", "have", "excellent", "activity", "against", "both", "Gram", "positive", "Gram", "negative", "pathogens", "likely", "to", "be", "involved", "in", "AECB", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2347728", "name": "C2347728#ent", "pos": [8, 9]}}
{"token": ["The", "nucleotide", "sequence", "these", "genes", "indicates", "PqqE", "belongs", "to", "an", "C0030946#ent", "<e1>", "including", "PqqF", "of", "C0519030#ent", "<e2>", "and", "M.", "extorquens", "AM1", "PqqF", "has", "low", "identity", "with", "the", "same", "C0030946#ent", "<e1>"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0519030", "name": "C0519030#ent", "pos": [15, 16]}}
{"token": ["No", "haematological", "abnormalities", "with", "C0014027#ent", "<e1>", "and", "there", "were", "no", "reports", "of", "C0015230#ent", "<e2>", ",", "taste", "disturbance", "proteinuria", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [12, 13]}}
{"token": ["In", "contrast", ",", "both", "cases", "of", "AGC", "were", "negative", "for", "CK5/6", "and", "C3811802#ent", "<e1>", "and", "were", "diffusely", "positive", "for", "C1416745#ent", "<e2>", "."], "h": {"id": "C3811802", "name": "C3811802#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416745", "name": "C1416745#ent", "pos": [19, 20]}}
{"token": ["A", "placebo-controlled", ",", "double-blind", "study", "evaluate", "the", "safety", "and", "prophylactic", "efficacy", "a", "low", "dose", "100", "mg", ")", "of", "C0282336#ent", "<e1>", "naturally", "occurring", "C0021400#ent", "<e2>", "in", "adults", "was", "conducted", "at", "two", "sites", "."], "h": {"id": "C0282336", "name": "C0282336#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [22, 23]}}
{"token": ["These", "effects", "were", "concomitant", "with", "increased", "activation", "status", "mitogen-activated", "protein", "kinase", "MAPK", ")", "family", "members", "extracellular", "regulated", "1", "and", "2", ",", "C1366876#ent", "<e1>", ",", "and", "c-Jun", "NH(2)-terminal", "kinase", "but", "not", "glycogen", "synthase", "kinase-3alphabeta", "C0249586#ent", "<e2>"], "h": {"id": "C1366876", "name": "C1366876#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0249586", "name": "C0249586#ent", "pos": [33, 34]}}
{"token": ["Five", "patients", "had", "a", "history", "of", "ischaemic", "heart", "disease", "three", "had", "hypertension", ",", "seven", "had", "heart", "failure", "two", "had", "C0001962#ent", "<e1>", "four", "had", "C0026265#ent", "<e2>", "and", "one", "patient", "with", "paroxysmal", "AF", "sick", "sinus", "syndrome"], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0026265", "name": "C0026265#ent", "pos": [23, 24]}}
{"token": ["After", "treatment", "with", "C0006230#ent", "<e1>", "a", "further", "reduction", "in", "C0022478#ent", "<e2>", "excretion", "was", "observed", "in", "SHR", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022478", "name": "C0022478#ent", "pos": [9, 10]}}
{"token": ["Both", "SULF1", "and", "C3539798#ent", "<e1>", "contain", "the", "cysteine", "residue", "in", "the", "active", "site", "many", "C1426909#ent", "<e2>", ",", "which", "is", "known", "to", "be", "posttranslationally", "modified", "into", "formylglycine", "in", "eukaryotic", "sulfatases", "."], "h": {"id": "C3539798", "name": "C3539798#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1426909", "name": "C1426909#ent", "pos": [14, 15]}}
{"token": ["Regimens", "using", "high-dose", "ara-C", "(", "C1422386#ent", "<e1>", ")", "in", "combination", "with", "mitoxantrone", ",", "C1271552#ent", "<e2>", ",", "or", "idarubicin", "are", "superior", "to", "C1422386#ent", "<e1>", "alone", "or", "with", "L-asparaginase", "."], "h": {"id": "C1271552", "name": "C1271552#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1422386", "name": "C1422386#ent", "pos": [5, 6]}}
{"token": ["However", ",", "the", "NLDs", "from", "human", "C2353079#ent", "<e1>", "and", "murine", "IRE1beta", "and", "the", "Caenorhabditis", "elegans", "C1414444#ent", "<e2>", "and", "PERK", "function", "as", "replacements", "for", "the", "S.", "cerevisiae", "to", "signal", "the", "unfolded", "protein", "response"], "h": {"id": "C2353079", "name": "C2353079#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1414444", "name": "C1414444#ent", "pos": [15, 16]}}
{"token": ["The", "C0006266#ent", "<e1>", "and", "cardiovascular", "effects", "of", "fenoterol", "hydrobromide", "C0700580#ent", "<e2>", "and", "in", "combination", "were", "investigated", "using", "metered", "aerosols", "guinea", "pigs", "and", "dogs", "and", "intravenous", "injection", "in", "dogs", "."], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0700580", "name": "C0700580#ent", "pos": [9, 10]}}
{"token": ["Quinpirole", ",", "7-OH-DPAT", ",", "C0006230#ent", "<e1>", "and", "apomorphine", "partially", "blocked", "the", "stimulus", "effects", "of", "C0040180#ent", "<e2>", "whereas", "SKF", "38393", "did", "not", "affect", "the", "discrimination", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0040180", "name": "C0040180#ent", "pos": [14, 15]}}
{"token": ["We", "demonstrate", "that", "C3537406#ent", "<e1>", "can", "interfere", "with", "C1538149#ent", "<e2>", "transcriptional", "repression", "that", "this", "is", "critical", "for", "APL", "pathogenesis", ",", "since", "leukemias", "in", "PLZF(-/-)/PLZF-RARalpha", "mutants", "and", "in", "PLZF-RARalpha/RARalpha-PLZF", "TM", "indistinguishable", "."], "h": {"id": "C3537406", "name": "C3537406#ent", "pos": [3, 4]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1538149", "name": "C1538149#ent", "pos": [8, 9]}}
{"token": ["Phosphoserine", "phosphatase", "C1868193#ent", "<e1>", ")", "is", "a", "member", "of", "a", "large", "class", "of", "C3541394#ent", "<e2>", "that", "catalyze", "phosphoester", "hydrolysis", "a", "phosphoaspartate-enzyme", "intermediate", "."], "h": {"id": "C1868193", "name": "C1868193#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [13, 14]}}
{"token": ["Taken", "together", ",", "these", "results", "indicate", "that", "35H", "is", "a", "new", ",", "widely", "expressed", "form", "of", "C0050734#ent", "<e1>", "capable", "of", "forming", "heterodimers", "with", "C1412230#ent", "<e2>", "."], "h": {"id": "C0050734", "name": "C0050734#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1412230", "name": "C1412230#ent", "pos": [23, 24]}}
{"token": ["Taken", "together", ",", "these", "results", "demonstrate", "that", "mammalian", "C0082874#ent", "<e1>", "biochemically", "distinct", "and", "suggest", "an", "entirely", "novel", "function", "for", "C1706022#ent", "<e2>", "in", "modulating", "HP1alpha-containing", "heterochromatic", "structures"], "h": {"id": "C0082874", "name": "C0082874#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706022", "name": "C1706022#ent", "pos": [19, 20]}}
{"token": ["During", "growth", "on", "C3669135#ent", "<e1>", ",", "all", "the", "organisms", "contain", "oxalyl-CoA", "decarboxylase", ",", "C0016570#ent", "<e2>", "oxalyl-CoA", "reductase", "."], "h": {"id": "C3669135", "name": "C3669135#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016570", "name": "C0016570#ent", "pos": [13, 14]}}
{"token": ["The", "relationship", "of", "C0154162#ent", "<e1>", "other", "forms", "of", "C0040147#ent", "<e2>", "is", "not", "clear", "."], "h": {"id": "C0154162", "name": "C0154162#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0040147", "name": "C0040147#ent", "pos": [8, 9]}}
{"token": ["It", "is", "not", "known", "whether", "C0154162#ent", "<e1>", "in", "the", "thyroid", "gland", "spreads", "or", "whether", "C0040147#ent", "<e2>", "part", "of", "a", "generalized", "process"], "h": {"id": "C0154162", "name": "C0154162#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0040147", "name": "C0040147#ent", "pos": [14, 15]}}
{"token": ["Patients", "with", "C0149931#ent", "<e1>", "and", "functional", "C0013395#ent", "<e2>", "may", "be", "characterised", "by", "meal-induced", "hypersensitivity", "of", "the", "stomach", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013395", "name": "C0013395#ent", "pos": [6, 7]}}
{"token": ["Diethylstilbestrol", "is", "a", "C3254086#ent", "<e1>", "has", "structural", "similarity", "to", "C0073096#ent", "<e2>", "."], "h": {"id": "C3254086", "name": "C3254086#ent", "pos": [3, 4]}, "relation": "gene_product_affected_by_chemical_or_drug", "t": {"id": "C0073096", "name": "C0073096#ent", "pos": [9, 10]}}
{"token": ["The", "amino", "acid", "sequence", "from", "the", "gene", "sequence", "well", "with", "members", "of", "the", "papain", "family", "C0769345#ent", "<e1>", "suggesting", "the", "name", "C0167118#ent", "<e2>", "."], "h": {"id": "C0769345", "name": "C0769345#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0167118", "name": "C0167118#ent", "pos": [20, 21]}}
{"token": ["Impaired", "C1420307#ent", "<e1>", "activity", "in", "humans", "has", "been", "associated", "with", "chronic", "diseases", "including", "ovarian", "cancer", "C0011860#ent", "<e2>", "and", "C1420307#ent", "<e1>", "overexpression", "appears", "to", "suppress", "malignancy", "in", "cultured", "cells"], "h": {"id": "C1420307", "name": "C1420307#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "co-expression", "of", "wildtype", "(", "wt", ")", "or", "S33A", "mutated", "C1332803#ent", "<e1>", "with", "Tcf-4", "did", "not", "influence", "C1332718#ent", "<e2>", "promoter", "activity"], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1332718", "name": "C1332718#ent", "pos": [18, 19]}}
{"token": ["PA", "did", "not", "affect", "C1826724#ent", "<e1>", "activity", ",", "but", "C1415467#ent", "<e2>", "treatment", "increased", "C1826724#ent", "<e1>", "activity", "the", "most", "."], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [4, 5]}}
{"token": ["Together", "with", "previous", "findings", ",", "these", "data", "firmly", "establish", "the", "concept", "that", "in", "mammalian", "tissues", "the", "two", "C0027203#ent", "<e1>", "activities", "are", "associated", "with", "single", "protein", "namely", "C1413943#ent", "<e2>"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1413943", "name": "C1413943#ent", "pos": [26, 27]}}
{"token": ["Brain", "SPECT", "C1421976#ent", "<e1>", "demonstrated", "the", "region", "of", "poor", "coronary", "vascular", "reserve", ",", "which", "suggested", "C0151744#ent", "<e2>", "induced", "by", "C1421976#ent", "<e1>", "in", "a", "patient", "with", "severe", "coronary", "artery", "disease"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1421976", "name": "C1421976#ent", "pos": [2, 3]}}
{"token": ["Cultured", "Cst10-/-", "chondrocytes", "showed", "a", "reduction", "in", "calcification", "with", "activation", "of", "an", "C1420418#ent", "<e1>", "site", "in", "the", "promoter", "of", "the", "gene", "encoding", "C0913019#ent", "<e2>", "NPP1", ",", "encoded", "by", "Enpp1", ")", "."], "h": {"id": "C1420418", "name": "C1420418#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0913019", "name": "C0913019#ent", "pos": [22, 23]}}
{"token": ["Those", "patients", "with", "a", "raised", "PCV", "but", "normal", "C1861861#ent", "<e1>", "either", "have", "apparent", "polycythaemia", "(", "normal", "plasma", "volume", "or", "C0221276#ent", "<e2>", "low", "plasma", "volume", "."], "h": {"id": "C1861861", "name": "C1861861#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0221276", "name": "C0221276#ent", "pos": [19, 20]}}
{"token": ["C1705658#ent", "<e1>", "also", "catalyzes", "the", "transamination", "of", "cystathionine", ",", "C0064651#ent", "<e2>", ",", "and", "thialysine", "to", "the", "corresponding", "alpha-keto", "acids", "which", "cyclize", "to", "ketimines", "."], "h": {"id": "C1705658", "name": "C1705658#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0064651", "name": "C0064651#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "BRCA2-dependent", "chromatin", "loading", "of", "C1419240#ent", "<e1>", "after", "mitomycin", "C", "treatment", "was", "not", "compromised", "by", "disruption", "of", "C1414529#ent", "<e2>", "or", "FANCD2", "."], "h": {"id": "C1419240", "name": "C1419240#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414529", "name": "C1414529#ent", "pos": [20, 21]}}
{"token": ["C1869199#ent", "<e1>", "PPs", ")", "represent", ",", "after", "C1335554#ent", "<e2>", "the", "second", "major", "class", "of", "enzymes", "that", "catalyze", "the", "dephosphorylation", "of", "proteins", "."], "h": {"id": "C1869199", "name": "C1869199#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [7, 8]}}
{"token": ["During", "C0009450#ent", "<e1>", "acrodermatitis", "chronica", "atrophicans", "an", "erythematous", ",", "atrophic", "plaque", "unique", "to", "C0024198#ent", "<e2>", "appear", ";", "it", "has", "been", "described", "in", "about", "10", "%", "of", "patients", "with", "C0024198#ent", "<e2>", "Europe", "."], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0024198", "name": "C0024198#ent", "pos": [13, 14]}}
{"token": ["Drugs", "can", "modulate", "the", "expression", "and", "actions", "of", "NO", ",", "a", "vasodilator", "with", "C0003392#ent", "<e1>", "and", "antithrombotic", "properties", "and", "of", "ET", ",", "a", "potent", "C0042397#ent", "<e2>", "and", "proliferative", "mitogenic", "agent"], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0042397", "name": "C0042397#ent", "pos": [24, 25]}}
{"token": ["C0003308#ent", "<e1>", "switched", "to", "caspofungin", "and", "C0064113#ent", "<e2>", "in", "two", "and", "one", "patients", ",", "respectively", "."], "h": {"id": "C0003308", "name": "C0003308#ent", "pos": [0, 1]}, "relation": "therapeutic_class_of", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [6, 7]}}
{"token": ["Enoxaparin", "(", "C0206460#ent", "<e1>", "is", "a", "low", "molecular", "weight", "heparin", "C0019139#ent", "<e2>", ")", "indicated", "for", "use", "in", "the", "treatment", "of", "ischaemic", "complications", "of", "unstable", "angina", "non-Q", "wave", "myocardial", "infarction", "MI", ")", "."], "h": {"id": "C0206460", "name": "C0206460#ent", "pos": [2, 3]}, "relation": "has_structural_class", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [10, 11]}}
{"token": ["T", "cell", "immunotherapies", "are", "particularly", "useful", "for", "the", "control", "of", "C0042769#ent", "<e1>", "provided", "that", "T", "cell", "populations", "are", "free", "of", "graft-vs-host", "C0856825#ent", "<e2>", ")", "activity", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0856825", "name": "C0856825#ent", "pos": [21, 22]}}
{"token": ["It", "is", "clear", "that", "the", "use", "of", "C0040615#ent", "<e1>", "treat", "psychiatric", "illness", "result", "in", "a", "variety", "of", "C0026650#ent", "<e2>"], "h": {"id": "C0040615", "name": "C0040615#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [17, 18]}}
{"token": ["Five", "additional", "patients", "had", "ocular", "manifestations", "uveitis", ",", "optic", "neuritis", "neuroretinitis", ",", "C0008513#ent", "<e1>", ",", "retinal", "hemorrhages", "arterial", "and", "venous", "occlusion", "vasculitis", ",", "and", "C0035333#ent", "<e2>", "."], "h": {"id": "C0008513", "name": "C0008513#ent", "pos": [12, 13]}, "relation": "has_nichd_parent", "t": {"id": "C0035333", "name": "C0035333#ent", "pos": [24, 25]}}
{"token": ["The", "clinical", "spectrum", "the", "cases", "varied", "widely", "from", "the", "tuberculoid", "to", "the", "lepromatous", "type", "one", "patient", "presented", "with", "C0017105#ent", "<e1>", "of", "the", "leg", "preceding", "an", "auto", "amputation", "was", "infested", "with", "C0027030#ent", "<e2>", "."], "h": {"id": "C0017105", "name": "C0017105#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0027030", "name": "C0027030#ent", "pos": [30, 31]}}
{"token": ["Additionally", ",", "C0017837#ent", "<e1>", "that", "E1B-AP5", "associates", "with", "RPA", "components", "C1419618#ent", "<e2>", "and", "RPA32", "directly", "in", "vitro"], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419618", "name": "C1419618#ent", "pos": [10, 11]}}
{"token": ["We", "have", "characterized", "mouse", "genomic", "clones", "the", "promoter", "regions", "for", "C1412215#ent", "<e1>", "gene", "transcription", "analyzed", "interferon", "induction", "the", "C2986617#ent", "<e2>", "mutant", "mouse", "cell", "lines", "."], "h": {"id": "C1412215", "name": "C1412215#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2986617", "name": "C2986617#ent", "pos": [18, 19]}}
{"token": ["Whereas", "the", "association", "of", "systemic", "illness", "musculoskeletal", "symptoms", "numerous", "C0042769#ent", "<e1>", "well", "known", ",", "such", "an", "association", "with", "C0019159#ent", "<e2>", "only", "been", "rarely", "reported", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0019159", "name": "C0019159#ent", "pos": [18, 19]}}
{"token": ["C1333690#ent", "<e1>", "changes", "which", "modify", "JNa", ",", "C0216660#ent", "<e2>", "and", "gK", ",", "do", "not", "affect", "the", "Na+", "transport", "by", "the", "pump", "as", "shown", "by", "kinetic", "and", "electrophysiological", "studies"], "h": {"id": "C1333690", "name": "C1333690#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0216660", "name": "C0216660#ent", "pos": [7, 8]}}
{"token": ["Treating", "elderly", "patients", "with", "pantoprazole", "(", "C0876139#ent", "<e1>", ")", "after", "resolution", "of", "C0149882#ent", "<e2>", "results", "in", "fewer", "relapses", "than", "with", "placebo", "(", "SOR", ":", "B", ",", "double-blind", "RCT", "."], "h": {"id": "C0876139", "name": "C0876139#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0149882", "name": "C0149882#ent", "pos": [12, 13]}}
{"token": ["Because", "c-fms", ",", "C0087140#ent", "<e1>", ",", "and", "c-myc", "are", "normally", "expressed", "early", "during", "C1704947#ent", "<e2>", "activation", ",", "our", "results", "suggest", "that", "tumor", "growth", "C1704947#ent", "<e2>", "inducing", "expression", "of", "these", "proto-oncogenes", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704947", "name": "C1704947#ent", "pos": [13, 14]}}
{"token": ["In", "two", "patients", ",", "C0004608#ent", "<e1>", "active", ",", "leading", "to", "significant", "C0024440#ent", "<e2>", "months", "and", "one", "year", "later", "."], "h": {"id": "C0004608", "name": "C0004608#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0024440", "name": "C0024440#ent", "pos": [11, 12]}}
{"token": ["We", "describe", "this", "phenomenon", "in", "the", "placenta", "of", "a", "19-year-old", "woman", "with", "C0024535#ent", "<e1>", "malaria", ",", "who", "was", "treated", "with", "combination", "of", "C0034414#ent", "<e2>", "and", "clindamycin", "."], "h": {"id": "C0024535", "name": "C0024535#ent", "pos": [12, 13]}, "relation": "may_be_prevented_by", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [22, 23]}}
{"token": ["This", "large", "intermediate", "product", "isolated", "and", "found", "to", "compete", "with", "intact", "C1413792#ent", "<e1>", "as", "a", "substrate", "for", "the", "C0030946#ent", "<e2>", "."], "h": {"id": "C1413792", "name": "C1413792#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [18, 19]}}
{"token": ["Additional", "studies", "are", "necessary", "to", "determine", "the", "effects", "of", "C0403559#ent", "<e1>", "rebound", "on", "the", "calculated", "clearance", "for", "C1412709#ent", "<e2>", "and", "other", "high-molecular-mass", "uraemic", "toxins", "."], "h": {"id": "C0403559", "name": "C0403559#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412709", "name": "C1412709#ent", "pos": [17, 18]}}
{"token": ["The", "C0039542#ent", "<e1>", "dose", "given", "resulted", "in", "plasma", "concentrations", "of", "C0039542#ent", "<e1>", "which", "improve", "lung", "function", "C0004096#ent", "<e1>", "patients", "."], "h": {"id": "C0039542", "name": "C0039542#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}}
{"token": ["We", "have", "constructed", "several", "strains", "with", "mitochondrial", "genomes", "different", "combinations", "of", "C1537988#ent", "<e1>", "and", "cox1", "introns", ",", "and", "associated", "these", "C0242965#ent", "<e2>", "with", "the", "disruption", "of", "SUV3", "."], "h": {"id": "C1537988", "name": "C1537988#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0242965", "name": "C0242965#ent", "pos": [20, 21]}}
{"token": ["These", "data", "support", "a", "model", "whereby", "CD5", "negatively", "regulates", "antigen", "receptor-mediated", "growth", "signals", "by", "recruiting", "C1335283#ent", "<e1>", "into", "the", "C0105421#ent", "<e2>", "B-1", "cells", "."], "h": {"id": "C1335283", "name": "C1335283#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0105421", "name": "C0105421#ent", "pos": [19, 20]}}
{"token": ["In", "general", ",", "the", "expression", "of", "C1704467#ent", "<e1>", "or", "bcl-x", "inhibits", "apoptosis", "while", "C0812198#ent", "<e2>", "promotes", "apoptosis", "."], "h": {"id": "C1704467", "name": "C1704467#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [13, 14]}}
{"token": ["Such", "success", "in", "animals", "encourages", "investigation", "of", "the", "potential", "use", "of", "vaccines", "in", "humans", "to", "prevent", "C0013502#ent", "<e1>", "from", "infection", "with", "Echinococcus", "granulosus", "cysticercosis", "from", "infection", "with", "C3488382#ent", "<e2>"], "h": {"id": "C0013502", "name": "C0013502#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3488382", "name": "C3488382#ent", "pos": [27, 28]}}
{"token": ["SHB", "operates", "downstream", "of", "C1705658#ent", "<e1>", "in", "cells", "that", "express", "this", "C0211705#ent", "<e2>", "."], "h": {"id": "C1705658", "name": "C1705658#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [11, 12]}}
{"token": ["Early", "diagnosis", "C1855648#ent", "<e1>", "and", "treatment", "with", "C1169994#ent", "<e2>", "avert", "a", "major", "cause", "of", "blindness", "in", "dogs", "."], "h": {"id": "C1855648", "name": "C1855648#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1169994", "name": "C1169994#ent", "pos": [7, 8]}}
{"token": ["The", "C1413248#ent", "<e1>", "of", "NDP", "was", "leukopenia", "and", "its", "MTD", "and", "C1418479#ent", "<e2>", "were", "160", "and", "150", "mg/m2", ",", "respectively", "."], "h": {"id": "C1413248", "name": "C1413248#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418479", "name": "C1418479#ent", "pos": [11, 12]}}
{"token": ["Administration", "of", "antihypertensive", "drugs", "diltiazem", ",", "C0014027#ent", "<e1>", "or", "propranolol", "to", "C0010592#ent", "<e2>", "treated", "animals", "augmented", "the", "endothelial", "damage", "induced", "by", "C0010592#ent", "<e2>", "."], "h": {"id": "C0014027", "name": "C0014027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [11, 12]}}
{"token": ["The", "etiology", "may", "be", "either", "idiopathic", "or", "in", "association", "with", "C0442893#ent", "<e1>", "as", "tuberculosis", ",", "rheumatoid", "arthritis", "C0027145#ent", "<e2>", "or", "hypercholesterolemia", "."], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027145", "name": "C0027145#ent", "pos": [17, 18]}}
{"token": ["A", "total", "of", "40", "transcripts", "were", "significantly", "upregulated", "by", "C0678021#ent", "<e1>", "in", "both", "control", "and", "bcl-2-transfectant", "C4282434#ent", "<e2>"], "h": {"id": "C0678021", "name": "C0678021#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4282434", "name": "C4282434#ent", "pos": [16, 17]}}
{"token": ["IL-1", "stimulation", "of", "IL-6", "or", "C0162745#ent", "<e1>", "production", "by", "fibroblasts", "was", "unaffected", "by", "C0043167#ent", "<e2>"], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [13, 14]}}
{"token": ["A", "long", "lasting", "sequence", "of", "co-operative", "negotiation", "meetings", "between", "the", "C0410422#ent", "<e1>", "and", "the", "chief", "information", "officer", "(", "C2678439#ent", "<e2>", ")", "led", "to", "appropriate", "outline", "of", "policies", "."], "h": {"id": "C0410422", "name": "C0410422#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2678439", "name": "C2678439#ent", "pos": [18, 19]}}
{"token": ["The", "earliest", "radiographics", "findings", "of", "C0010346#ent", "<e1>", "represented", "by", "C0038363#ent", "<e2>"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0038363", "name": "C0038363#ent", "pos": [9, 10]}}
{"token": ["In", "hepatocytes", "cultured", "in", "basal", "medium", "C1412624#ent", "<e1>", "was", "localized", "in", "the", "perinuclear", "cytoplasm", "and", "C3273406#ent", "<e2>", "observed", "in", "the", "Golgi", "region", "the", "cytoplasm", "."], "h": {"id": "C1412624", "name": "C1412624#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [15, 16]}}
{"token": ["Phenol", "sulfotransferase", "C1539876#ent", "<e1>", ")", "catalyzes", "the", "sulfate", "conjugation", "of", "phenolic", "monoamines", "and", "C0013227#ent", "<e2>"], "h": {"id": "C1539876", "name": "C1539876#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [13, 14]}}
{"token": ["The", "addition", "of", "calcium", "phosphate", "as", "in", "C1539201#ent", "<e1>", "scaffolds", "increased", "the", "ALP", "and", "C1412791#ent", "<e2>", "levels", "of", "MG63", "cells", "."], "h": {"id": "C1539201", "name": "C1539201#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412791", "name": "C1412791#ent", "pos": [14, 15]}}
{"token": ["To", "investigate", "immune", "aberration", "in", "the", "pathogenesis", "of", "BD", ",", "we", "studied", "the", "expression", "of", "Txk", "and", "C1423842#ent", "<e1>", "cytokines", "in", "peripheral", "blood", "lymphocytes", "PBL", ")", "and", "C0037284#ent", "<e2>", "patients", "with", "BD", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0037284", "name": "C0037284#ent", "pos": [27, 28]}}
{"token": ["For", "C1879767#ent", "<e1>", "only", "1/153", "(", "homozygous", ")", "tumours", "showed", "a", "contracted", "C1706112#ent", "<e2>", ",", "with", "minor", "size", "variations", "(", "1", "-", "6", "bp", ")", "between", "individuals", "."], "h": {"id": "C1879767", "name": "C1879767#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706112", "name": "C1706112#ent", "pos": [12, 13]}}
{"token": ["Staurosporine", ",", "a", "potent", "C1514555#ent", "<e1>", "blocked", "GVBD", "and", "the", "activation", "of", "C0079805#ent", "<e2>", "whereas", "HA1004", ",", "which", "preferentially", "antagonizes", "protein", "kinase", "A", "had", "no", "effect"], "h": {"id": "C1514555", "name": "C1514555#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0079805", "name": "C0079805#ent", "pos": [12, 13]}}
{"token": ["The", "inducible", "nature", "of", "the", "C0206256#ent", "<e1>", "IEGs", ")", "c-fos", "and", "C1414314#ent", "<e2>", "allows", "their", "products", "to", "be", "used", "as", "activity", "markers", "the", "brain", "."], "h": {"id": "C0206256", "name": "C0206256#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414314", "name": "C1414314#ent", "pos": [11, 12]}}
{"token": ["Delayed-early", "expression", "nur77", "is", "mediated", "by", "multiple", "AP-1-like", "and", "GC-rich", "elements", ",", "which", "can", "interact", "with", "products", "of", "C0206256#ent", "<e1>", "as", "Fos/Jun", "and", "C1414314#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0206256", "name": "C0206256#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1414314", "name": "C1414314#ent", "pos": [23, 24]}}
{"token": ["STAT1", "and", "C1333571#ent", "<e1>", "both", "required", "for", "C1428026#ent", "<e2>", "gene", "expression", "interact", "normally", "in", "CF", "cells"], "h": {"id": "C1333571", "name": "C1333571#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1428026", "name": "C1428026#ent", "pos": [7, 8]}}
{"token": ["In", "neurons", ",", "endogenous", "MKL1", "was", "associated", "with", "chromatin", "regions", "of", "several", "endogenous", "genes", "including", "C1706383#ent", "<e1>", ",", "JunB", ",", "Srf", ",", "and", "C1413896#ent", "<e2>", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1413896", "name": "C1413896#ent", "pos": [23, 24]}}
{"token": ["Since", "postprandial", "hyperglycemia", "could", "be", "well", "treated", "by", "C0903898#ent", "<e1>", ",", "we", "examined", "the", "background", "factors", "of", "C0011860#ent", "<e2>", "patients", "to", "determine", "the", "optimal", "indication", "for", "C0903898#ent", "<e1>", "."], "h": {"id": "C0903898", "name": "C0903898#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0011860", "name": "C0011860#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "C1840636#ent", "<e1>", "could", "transform", "cells", "direct", "regulation", "of", "downstream", "target", "C1417679#ent", "<e2>", ",", "acting", "through", "homodimeric", "or", "heterodimeric", "complexes", "or", "by", "sequestering", "normal", "PAR", "proteins", "nonfunctional", "heterocomplexes", "(", "dominant-negative", "interference", "."], "h": {"id": "C1840636", "name": "C1840636#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["C0014541#ent", "<e1>", "to", "infection", "with", "Haemophilus", "influenzae", "type", "b", "C0018482#ent", "<e2>", ")", "is", "much", "less", "common", "in", "children", "following", "the", "introduction", "of", "Hib", "vaccination", "however", ",", "adult", "epiglottitis", "cases", "have", "not", "decreased", "."], "h": {"id": "C0014541", "name": "C0014541#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018482", "name": "C0018482#ent", "pos": [9, 10]}}
{"token": ["In", "response", "to", "insulin", ",", "the", "C1421420#ent", "<e1>", "content", "decreased", "in", "the", "C4083146#ent", "<e2>", "and", "increased", "in", "the", "PM", ",", "suggesting", "translocation", "akin", "to", "that", "of", "the", "GLUT4", "glucose", "transporter"], "h": {"id": "C1421420", "name": "C1421420#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C4083146", "name": "C4083146#ent", "pos": [12, 13]}}
{"token": ["From", "the", "above", "results", ",", "PZ-177", "may", "be", "classified", "as", "a", "potent", "C0728960#ent", "<e1>", "and", "anti-inflammatory", "agent", "has", "no", "effect", "proliferation", "of", "granulation", "tissue", "C1290884#ent", "<e2>"], "h": {"id": "C0728960", "name": "C0728960#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [24, 25]}}
{"token": ["Laboratory", "findings", "include", "leukocytosis", ",", "neutrophilia", ",", "low", "hemoglobin", "hypoalbuminemia", ",", "hypobetaglobulinemia", ",", "C0154254#ent", "<e1>", ",", "decreased", "serum", "fatty", "acids", "hypocholesterolemia", ",", "C0268477#ent", "<e2>", ",", "low", "fecal", "pH", ",", "and", "increased", "fecal", "fat", "nitrogen", "."], "h": {"id": "C0154254", "name": "C0154254#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268477", "name": "C0268477#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "the", "expression", "and", "clinical", "significance", "C0812204#ent", "<e1>", ",", "Fas", "and", "C1539478#ent", "<e2>", "in", "colorectal", "carcinoma", "tissues", "."], "h": {"id": "C0812204", "name": "C0812204#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [12, 13]}}
{"token": ["Lastly", ",", "the", "elg1Delta", "mutation", "increases", "telomere", "size", "independently", "of", "other", "previously", "known", "C1336700#ent", "<e1>", "as", "the", "telomerase", "inhibitor", "C1332686#ent", "<e2>", "or", "the", "telomere", "size", "regulator", "Rif1", "."], "h": {"id": "C1336700", "name": "C1336700#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1332686", "name": "C1332686#ent", "pos": [19, 20]}}
{"token": ["We", "therefore", "phenotyped", "64", "C1334982#ent", "<e1>", "primates", "for", "debrisoquine", "and", "C0025381#ent", "<e2>", "polymorphisms", "and", "identified", "poor", "metabolizers", "of", "both", "drugs", "."], "h": {"id": "C1334982", "name": "C1334982#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025381", "name": "C0025381#ent", "pos": [10, 11]}}
{"token": ["Activities", "of", "two", "brush", "border", "enzymes", ",", "alkaline", "phosphatase", "C1366565#ent", "<e1>", ")", "and", "gamma-glutamyl-transpeptidase", "(", "GGT", ")", ",", "and", "a", "C0085078#ent", "<e2>", "N-acetyl-beta-D-glucosaminidase", "(", "NAG", ")", ",", "were", "measured", "in", "24-hr", "urine", "collections"], "h": {"id": "C1366565", "name": "C1366565#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0085078", "name": "C0085078#ent", "pos": [20, 21]}}
{"token": ["Addition", "of", "recombinant", "sFRP-1", "to", "ex", "vivo", "perfusion-cultured", "human", "C0235267#ent", "<e1>", "decreased", "outflow", "facility", ",", "concomitant", "with", "reduced", "levels", "of", "C1332803#ent", "<e2>", ",", "the", "Wnt", "signaling", "mediator", "in", "the", "TM", "."], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [20, 21]}}
{"token": ["Calcium", "pyrophosphate", "dihydrate", "CPPD", ")", "deposition", "disease", "C0856830#ent", "<e1>", ")", ",", "also", "known", "as", "C0033802#ent", "<e2>", ",", "is", "rarely", "known", "to", "affect", "the", "spine", "."], "h": {"id": "C0856830", "name": "C0856830#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0033802", "name": "C0033802#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "C1417018#ent", "<e1>", ",", "a", "mammalian", "Ste20-related", "protein-serine/threonine", "kinase", "can", "potentially", "associate", "with", "C0812288#ent", "<e2>", "interactions", "mediated", "by", "SH2/SH3", "adaptors", "as", "Grb2", "."], "h": {"id": "C1417018", "name": "C1417018#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812288", "name": "C0812288#ent", "pos": [16, 17]}}
{"token": ["Herein", "we", "describe", "a", "male", "homosexual", "with", "the", "acquired", "C0021051#ent", "<e1>", "became", "severely", "C0020625#ent", "<e2>", "during", "bowel", "preparation", "colonoscopy", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [13, 14]}}
{"token": ["Importantly", ",", "we", "identify", "an", "EcR", "mutant", "C0002085#ent", "<e1>", "that", "fails", "to", "bind", "C1334871#ent", "<e2>", "and", "is", "characterized", "by", "developmental", "defects", "lethality", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334871", "name": "C1334871#ent", "pos": [13, 14]}}
{"token": ["To", "improve", "haemodynamic", "assessment", "patients", "with", "C0007282#ent", "<e1>", "we", "evaluated", "a", "novel", "global", "cerebral", "blood", "flow", "C1428360#ent", "<e2>", ")", "heterogeneity", "index", "rest", "and", "after", "acetazolamide", "injection", "in", "patients", "undergoing", "carotid", "endarterectomy"], "h": {"id": "C0007282", "name": "C0007282#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1428360", "name": "C1428360#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "expression", "of", "a", "number", "of", "putative", "C1427164#ent", "<e1>", "target", "genes", "was", "sensitive", "to", "C1705590#ent", "<e2>", "inhibition", "."], "h": {"id": "C1427164", "name": "C1427164#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705590", "name": "C1705590#ent", "pos": [16, 17]}}
{"token": ["The", "deduced", "proteins", "from", "5", "'", "and", "3", "'", "cDNA", "ends", "have", "a", "high", "degree", "of", "homology", "to", "humans", "and", "mouse", "C1417861#ent", "<e1>", "at", "the", "C2917660#ent", "<e2>", "level", "."], "h": {"id": "C1417861", "name": "C1417861#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [25, 26]}}
{"token": ["It", "is", "concluded", "that", "coadministration", "of", "C0081408#ent", "<e1>", "1.6", "g/day", "has", "no", "significant", "effects", "on", "the", "pharmacokinetics", "of", "C2239905#ent", "<e2>", "2", "g/day", "or", "its", "metabolites", ",", "SP", "and", "ASP", "."], "h": {"id": "C0081408", "name": "C0081408#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2239905", "name": "C2239905#ent", "pos": [18, 19]}}
{"token": ["In", "the", "same", "patients", ",", "C1414083#ent", "<e1>", "values", "were", "obtained", "by", "dual-energy", "X-ray", "absorptiometry", "lumbar", "spine", "the", "beginning", "and", "C1704837#ent", "<e2>", "treatment", "."], "h": {"id": "C1414083", "name": "C1414083#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704837", "name": "C1704837#ent", "pos": [19, 20]}}
{"token": ["Cilia", "dysfunction", "also", "implicated", "in", "a", "wider", "spectrum", "of", "C0029896#ent", "<e1>", "due", "to", "impaired", "organ", "C1414672#ent", "<e2>", "and", "body", "symmetry"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [15, 16]}}
{"token": ["A", "synthesis", "of", "the", "C0007158#ent", "<e1>", "the", "tetrasaccharide", "side", "chain", "the", "major", "C0072522#ent", "<e2>", "of", "Bacillus", "anthracis", "a", "[", "3", "+", "1", "]", "approach", "is", "described", "."], "h": {"id": "C0007158", "name": "C0007158#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072522", "name": "C0072522#ent", "pos": [12, 13]}}
{"token": ["Such", "factors", "have", "been", "detected", "in", "the", "CNS", "of", "animal", "models", "C1417325#ent", "<e1>", "in", "the", "brains", "of", "human", "and", "nonhuman", "primates", "with", "C0014038#ent", "<e2>"], "h": {"id": "C1417325", "name": "C1417325#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [22, 23]}}
{"token": ["C0041364#ent", "<e1>", "manifested", "by", "various", "C0025517#ent", "<e2>", "is", "a", "known", "complication", "after", "treatment", "of", "some", "lymphoid", "malignancies"], "h": {"id": "C0041364", "name": "C0041364#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}}
{"token": ["The", "effect", "of", "methyl-p-hydroxybenzoate", ",", "propyl-p-hydroxybenzoate", ",", "C0008232#ent", "<e1>", ",", "chlorocresol", ",", "EDTA", ",", "benzalkonium", "chloride", "chlorhexidine", ",", "C0301304#ent", "<e2>", "phenylmercuric", "borate", "mucociliary", "transport", "rate", "of", "the", "frog", "palate", "been", "examined", "."], "h": {"id": "C0008232", "name": "C0008232#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0301304", "name": "C0301304#ent", "pos": [18, 19]}}
{"token": ["Search", "terms", "included", "C0010340#ent", "<e1>", "pediatric", "intensive", "care", ",", "trauma", ",", "sepsis", ",", "infectious", "diseases", "C0022806#ent", "<e2>", ",", "inflammatory", "response", "surgery", ",", "starvation", ",", "respiratory", "failure", "diuretic", ",", "steroid", ",", "antiacid", "therapy", "mechanical", "ventilation"], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022806", "name": "C0022806#ent", "pos": [15, 16]}}
{"token": ["Extensively", "drug-resistant", "tuberculosis", "C4287840#ent", "<e1>", ")", "is", "an", "emerging", "health", "problem", "threatens", "C0041296#ent", "<e2>", "(", "TB", ")", "control", "worldwide", ",", "since", "suitable", "treatment", "for", "this", "disease", "has", "not", "yet", "been", "found", "."], "h": {"id": "C4287840", "name": "C4287840#ent", "pos": [3, 4]}, "relation": "has_nichd_parent", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [12, 13]}}
{"token": ["The", "C0013227#ent", "<e1>", "is", "indicated", "for", "'", "severe", "C0150055#ent", "<e2>", "and", "is", "administered", "intrathecally", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0150055", "name": "C0150055#ent", "pos": [8, 9]}}
{"token": ["Both", "relaxation", "and", "activation", "of", "C0010287#ent", "<e1>", "were", "abolished", "during", "beta-adrenergic", "blockade", "C0033497#ent", "<e2>", "."], "h": {"id": "C0010287", "name": "C0010287#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [12, 13]}}
{"token": ["In", "Japan", ",", "some", "of", "these", "instruments", "are", "translated", "into", "the", "Japanese", "and", "are", "used", "for", "the", "measurement", "of", "C0518214#ent", "<e1>", "of", "various", "C0012634#ent", "<e2>", "."], "h": {"id": "C0518214", "name": "C0518214#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [23, 24]}}
{"token": ["Direct", "sequencing", "the", "amplified", "14q+", "junctions", "established", "that", "the", "C0376515#ent", "<e1>", "(", "major", "breakpoint", "region", "sequence", "was", "fused", "to", "an", "Ig", "joining", "region", "C1415529#ent", "<e2>", ")", "(", "J6", "in", "all", "four", "cases", ")", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1415529", "name": "C1415529#ent", "pos": [23, 24]}}
{"token": ["Recombinant", "human", "glucocerebrosidase", "imiglucerase", ",", "C0291139#ent", "<e1>", ")", "is", "used", "in", "enzyme", "replacement", "therapy", "C1961835#ent", "<e2>"], "h": {"id": "C0291139", "name": "C0291139#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1961835", "name": "C1961835#ent", "pos": [14, 15]}}
{"token": ["Likewise", "C1706508#ent", "<e1>", "phosphorylation", "was", "robust", "in", "the", "C1883559#ent", "<e2>", "scrambled-transfected", "HUVEC", "but", "not", "in", "the", "C1706508#ent", "<e1>", "antisense-HUVEC", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706508", "name": "C1706508#ent", "pos": [1, 2]}}
{"token": ["The", "diagnosis", "of", "neurological", "involvement", "in", "the", "context", "of", "C0442893#ent", "<e1>", "be", "helped", "by", "the", "detection", "of", "autoantibodies", "reacting", "against", "C1413096#ent", "<e2>"], "h": {"id": "C0442893", "name": "C0442893#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [20, 21]}}
{"token": ["Cotreatment", "with", "the", "antimigraine", "drug", "C0075632#ent", "<e1>", "greatly", "repressed", "nitric", "oxide", "stimulation", "of", "C1705783#ent", "<e2>", "promoter", "activity", "secretion", "."], "h": {"id": "C0075632", "name": "C0075632#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705783", "name": "C1705783#ent", "pos": [13, 14]}}
{"token": ["Mesalazine", "(", "C0127615#ent", "<e1>", ")", "is", "a", "C0085387#ent", "<e2>", "anti-inflammatory", "drug", "in", "Crohn's", "disease", "ulcerative-colitis", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [7, 8]}}
{"token": ["Release", "of", "[14C]Ach", "was", "evoked", "with", "NH2Cl", "in", "the", "absence", "and", "presence", "of", "C0127615#ent", "<e1>", "glutathione", ",", "nordihydroguaiarectic", "acid", "the", "C0085387#ent", "<e2>", "piroxicam", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [20, 21]}}
{"token": ["C0127615#ent", "<e1>", "(", "5-ASA", ")", "is", "a", "C0085387#ent", "<e2>", "anti-inflammatory", "drug", "in", "Crohn's", "disease", "ulcerative-colitis", "."], "h": {"id": "C0127615", "name": "C0127615#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0085387", "name": "C0085387#ent", "pos": [7, 8]}}
{"token": ["The", "mammalian", "D-type", "cyclins", "D1", ",", "C1415944#ent", "<e1>", ",", "and", "D3", "activate", "the", "cyclin-dependent", "kinases", "CDK4", "C1565313#ent", "<e2>", "in", "G1", "and", "thereby", "promote", "the", "cell", "'s", "commitment", "to", "enter", "S", "phase"], "h": {"id": "C1415944", "name": "C1415944#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1565313", "name": "C1565313#ent", "pos": [16, 17]}}
{"token": ["In", "common", "with", "several", "other", "respiratory", "and", "photosynthetic", "C0014442#ent", "<e1>", ",", "a", "sub-population", "of", "cytosolic", "phosphoglycerate", "kinase", "C1418929#ent", "<e2>", ")", "occurs", "in", "the", "nucleus", "in", "pea", "leaves", "shoots", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418929", "name": "C1418929#ent", "pos": [17, 18]}}
{"token": ["Preproenkephalin", "gene", "transcription", "was", "analysed", "by", "introducing", "the", "C1418457#ent", "<e1>", "fused", "to", "the", "C0008169#ent", "<e2>", "primary", "neurons", "."], "h": {"id": "C1418457", "name": "C1418457#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008169", "name": "C0008169#ent", "pos": [13, 14]}}
{"token": ["Infertility", "is", "sometime", "associated", "to", "C0042341#ent", "<e1>", "and", "with", "the", "unrelieved", "C0231218#ent", "<e2>", "the", "main", "indications", "for", "surgery", "."], "h": {"id": "C0042341", "name": "C0042341#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [11, 12]}}
{"token": ["C1420855#ent", "<e1>", "has", "potential", "binding", "sequences", "C1336678#ent", "<e2>", ",", "which", "is", "one", "of", "key", "regulators", "of", "the", "multivesicular", "body", "MVB", ")", "formation", "."], "h": {"id": "C1420855", "name": "C1420855#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1336678", "name": "C1336678#ent", "pos": [6, 7]}}
{"token": ["We", "have", "isolated", "the", "mouse", "C1420104#ent", "<e1>", "cDNA", "and", "C0017337#ent", "<e2>", "and", "characterized", "the", "pattern", "of", "tissue", "expression", "."], "h": {"id": "C1420104", "name": "C1420104#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [9, 10]}}
{"token": ["C1708291#ent", "<e1>", "was", "the", "only", "component", "of", "a", "C0282109#ent", "<e2>", "of", "transcription", "isolated", "as", "a", "Tuplp-interacting", "protein", "in", "this", "screen", "."], "h": {"id": "C1708291", "name": "C1708291#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0282109", "name": "C0282109#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "this", "study", "supports", "the", "hypothesis", "that", "a", "C3537293#ent", "<e1>", "response", "is", "required", "for", "optimal", "eradication", "of", "C0024198#ent", "<e2>", "."], "h": {"id": "C3537293", "name": "C3537293#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0024198", "name": "C0024198#ent", "pos": [19, 20]}}
{"token": ["Metoprolol", "(", "10(-6", ")", "M", ")", ",", "a", "selective", "C1516869#ent", "<e1>", "shifted", "the", "concentration-response", "curve", "C0282211#ent", "<e2>", "to", "the", "right", ",", "but", "left", "the", "maximal", "response", "unchanged", "."], "h": {"id": "C1516869", "name": "C1516869#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0282211", "name": "C0282211#ent", "pos": [15, 16]}}
{"token": ["To", "date", ",", "the", "short-acting", "C0242896#ent", "<e1>", "ipratropium", "and", "C0134499#ent", "<e2>", "been", "extensively", "employed", "as", "bronchodilator", "therapy", "patients", "with", "COPD", "."], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0134499", "name": "C0134499#ent", "pos": [9, 10]}}
{"token": ["We", "show", "here", "that", "Integrin-Linked", "Kinase", "ILK", ")", "regulates", "C0694872#ent", "<e1>", "expression", "through", "C0032405#ent", "<e2>", "PARP-1", ")", "."], "h": {"id": "C0694872", "name": "C0694872#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032405", "name": "C0032405#ent", "pos": [13, 14]}}
{"token": ["In", "the", "clinical", "study", "six", "infants", "with", "post-cardiac", "surgery", "low", "output", "syndrome", "maximal", "C3536742#ent", "<e1>", "inotropic", "support", "were", "given", "C0116190#ent", "<e2>", "(", "i.v", "."], "h": {"id": "C3536742", "name": "C3536742#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0116190", "name": "C0116190#ent", "pos": [19, 20]}}
{"token": ["In", "vitro", "C1415764#ent", "<e1>", "(", "70", "kDa", "heat", "shock", "cognate", "protein", "and", "SGT", "(", "small", "glutamine-rich", "tetratricopeptide", "repeat", "domain", "protein", "switch", "C1413231#ent", "<e2>", "from", "an", "inactive", "GEF", "to", "an", "active", "GEF", "."], "h": {"id": "C1415764", "name": "C1415764#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413231", "name": "C1413231#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", "to", "the", "C2987364#ent", "<e1>", ",", "strain", "AN70", "contained", "only", "C1414085#ent", "<e2>", ",", "but", "no", "MK", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414085", "name": "C1414085#ent", "pos": [11, 12]}}
{"token": ["We", "found", "that", "eNOS", ",", "which", "is", "endogenously", "expressed", "by", "these", "cells", ",", "was", "activated", "by", "tumour", "necrosis", "factor-alpha", "C1710304#ent", "<e1>", ")", ",", "a", "proinflammatory", "cytokine", "plays", "important", "roles", "in", "C1412367#ent", "<e2>", "and", "several", "neurodegenerative", "diseases"], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412367", "name": "C1412367#ent", "pos": [30, 31]}}
{"token": ["IL-2", "and/or", "C1824201#ent", "<e1>", "were", "injected", "into", "the", "pleural", "or", "pericardial", "spaces", "C0220655#ent", "<e2>", "showing", "significant", "effects", "on", "a", "lung", "cancer", "patient", "with", "cancerous", "pericarditis", "survived", "more", "than", "9", "months", "after", "this", "localized", "therapy"], "h": {"id": "C1824201", "name": "C1824201#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0220655", "name": "C0220655#ent", "pos": [12, 13]}}
{"token": ["However", ",", "local", "production", "C1418558#ent", "<e1>", "is", "significantly", "down-regulated", "in", "inflammatory", "bowel", "disease", "C0022104#ent", "<e2>", ")", ",", "as", "revealed", "by", "strikingly", "decreased", "J-chain", "expression", "."], "h": {"id": "C1418558", "name": "C1418558#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022104", "name": "C0022104#ent", "pos": [13, 14]}}
{"token": ["Tacrolimus", "(", "FK506", ",", "C1538925#ent", "<e1>", ")", "is", "marketed", "for", "the", "prophylaxis", "of", "organ", "rejection", "allogenic", "C0023899#ent", "<e2>", "or", "kidney", "transplantation"], "h": {"id": "C1538925", "name": "C1538925#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [16, 17]}}
{"token": ["A", "63-year-old", "man", "presented", "with", "C0011606#ent", "<e1>", ",", "peripheral", "blood", "eosinophilia", "elevated", "serum", "IgE", "levels", ",", "and", "a", "history", "of", "dermatitis", "C0016867#ent", "<e2>", ",", "and", "a", "cold", "abscess"], "h": {"id": "C0011606", "name": "C0011606#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0016867", "name": "C0016867#ent", "pos": [21, 22]}}
{"token": ["To", "establish", "clinical", "manifestations", "metabolic", "bone", "disease", "bone", "mineral", "density", "C1826421#ent", "<e1>", ")", "in", "young", "adult", "patients", "with", "C3714757#ent", "<e2>", "we", "performed", "a", "long-term", "outcome", "study"], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [18, 19]}}
{"token": ["C2606719#ent", "<e1>", "Hje", ")", "from", "Sulfolobus", "solfataricus", "a", "resolving", "C0027203#ent", "<e2>", "involved", "in", "cleaving", "specific", "sites", "on", "either", "side", "of", "recombinant", "four-way", "HolliDay", "junctions"], "h": {"id": "C2606719", "name": "C2606719#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}}
{"token": ["CC", "chemokine", "receptor", "9", "C1332673#ent", "<e1>", ")", "is", "a", "specific", "receptor", "for", "thymus-expressed", "CC", "chemokine", "C1707084#ent", "<e2>", ")", "."], "h": {"id": "C1332673", "name": "C1332673#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1707084", "name": "C1707084#ent", "pos": [15, 16]}}
{"token": ["To", "determine", "which", "biochemical", "test", "best", "to", "distinguish", "C0030305#ent", "<e1>", "other", "pancreatic", "and", "C0030286#ent", "<e2>", "associated", "with", "hyperamylasemia", "."], "h": {"id": "C0030305", "name": "C0030305#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0030286", "name": "C0030286#ent", "pos": [13, 14]}}
{"token": ["Chronic", "treatment", "neuroleptic", "drugs", "as", "haloperidol", "(", "C1327841#ent", "<e1>", ")", "can", "result", "in", "a", "C1848862#ent", "<e2>", "of", "abnormal", "involuntary", "movements", "as", "tardive", "dyskinesia", "TD", ")", "."], "h": {"id": "C1327841", "name": "C1327841#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [14, 15]}}
{"token": ["The", "disease", "manifested", "itself", "in", "a", "patient", "being", "treated", "for", "C0857305#ent", "<e1>", "by", "progressive", "administration", "of", "C0002600#ent", "<e2>", "."], "h": {"id": "C0857305", "name": "C0857305#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0002600", "name": "C0002600#ent", "pos": [16, 17]}}
{"token": ["Identification", "of", "C1419275#ent", "<e1>", "in", "these", "three", "additional", "species", "facilitated", "development", "of", "this", "C0079429#ent", "<e2>", "as", "a", "molecular", "marker", "diatom", "sexual", "events"], "h": {"id": "C1419275", "name": "C1419275#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}}
{"token": ["However", ",", "cotransfection", "of", "the", "C1334506#ent", "<e1>", "promoter", "with", "myogenic", "regulatory", "factors", "including", "MyoD", "and", "C2986638#ent", "<e2>", ",", "produced", "less", "than", "2-fold", "activation", "compared", "with", "20-fold", "activation", "of", "the", "desmin", "promoter"], "h": {"id": "C1334506", "name": "C1334506#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2986638", "name": "C2986638#ent", "pos": [15, 16]}}
{"token": ["Therefore", "citrin", "deficiency", "various", "and", "complicated", "metabolic", "disturbances", "such", "as", "C0020615#ent", "<e1>", ",", "hyperlactic", "acidemia", "hyperammonemia", ",", "hypoproteinemia", ",", "hyperlipidemia", ",", "and", "C0268151#ent", "<e2>", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268151", "name": "C0268151#ent", "pos": [22, 23]}}
{"token": ["The", "hGH", "response", "to", "C0020615#ent", "<e1>", "was", "significantly", "impaired", "after", "treatment", "with", "C0016368#ent", "<e2>", "."], "h": {"id": "C0020615", "name": "C0020615#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0016368", "name": "C0016368#ent", "pos": [12, 13]}}
{"token": ["dose", "of", "anti-Thy-1-gelonin", "killed", "90", "%", "to", "99", "%", "cells", "in", "vivo", "and", "that", "the", "C2698914#ent", "<e1>", "was", "about", "as", "effective", "in", "this", "model", "as", "either", "C0085752#ent", "<e2>", "or", "cytoxan", "."], "h": {"id": "C2698914", "name": "C2698914#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [26, 27]}}
{"token": ["Human", "plasma", "alpha", "1-", "and", "C1537501#ent", "<e1>", "alpha", "1,2TPIs", ")", "inhibited", "purified", "Ca-activated", "neutral", "protease", "C1825242#ent", "<e2>", ")", "most", "strongly", "among", "a", "number", "of", "thiol", "proteinases", "tested", "."], "h": {"id": "C1537501", "name": "C1537501#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1825242", "name": "C1825242#ent", "pos": [15, 16]}}
{"token": ["Proteolysis", "was", "more", "marked", "and", "rapid", "in", "cheese", "containing", "C.", "cardunculus", "as", "C0009117#ent", "<e1>", ",", "the", "SN", "and", "C2829948#ent", "<e2>", "contents", "of", "which", "were", "significantly", "higher", "p", "<", "0", "."], "h": {"id": "C0009117", "name": "C0009117#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2829948", "name": "C2829948#ent", "pos": [18, 19]}}
{"token": ["C0030193#ent", "<e1>", "osteoarthritis", "can", "be", "positively", "influenced", "by", "C0000970#ent", "<e2>", "and", "NSAR", ",", "in", "combination", "with", "orthopedic", "aids", "physical", "therapy", "early", "stages"], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [0, 1]}, "relation": "may_be_prevented_by", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [8, 9]}}
{"token": ["The", "ratios", "of", "sweetener", "to", "activated", "C0001275#ent", "<e1>", "were", "1:1", "for", "C1161331#ent", "<e2>", "and", "sorbitol", ",", "and", "1:20", "for", "saccharin", "sodium"], "h": {"id": "C0001275", "name": "C0001275#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [11, 12]}}
{"token": ["Similar", "to", "the", "tau-binding", "results", ",", "C0052199#ent", "<e1>", ",", "but", "not", "apoE4", ",", "bound", "C1417006#ent", "<e2>", "."], "h": {"id": "C0052199", "name": "C0052199#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417006", "name": "C1417006#ent", "pos": [14, 15]}}
{"token": ["With", "C1420459#ent", "<e1>", "impressive", "improvements", "in", "the", "clinical", "course", "obstructive", "jaundice", "cholangitis", "and", "C0001339#ent", "<e2>", "in", "children", "and", "adolescents", "can", "be", "reached", "."], "h": {"id": "C1420459", "name": "C1420459#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [13, 14]}}
{"token": ["SA", ":", "shikonin/alkannin", "PE", ":", "C0031469#ent", "<e1>", "Ach", ":", "acetylcholine", "SNP", ":", "sodium", "nitroprusside", "eNOS", ":", "C0907532#ent", "<e2>", "L-NAME", ":", "Nw-nitro-", "L-arginine", "methyl", "ester"], "h": {"id": "C0031469", "name": "C0031469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0907532", "name": "C0907532#ent", "pos": [16, 17]}}
{"token": ["Plasma", "membrane", "fluidity", "and", "heterogeneity", "of", "C0064833#ent", "<e1>", "PMN", ")", "were", "investigated", "in", "seven", "children", "with", "C0008780#ent", "<e2>", "PCD", ")", "and", "17", "healthy", "controls"], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0008780", "name": "C0008780#ent", "pos": [16, 17]}}
{"token": ["The", "induction", "of", "C3538729#ent", "<e1>", "may", "serve", "as", "a", "novel", "pharmacological", "pathway", "for", "C0245514#ent", "<e2>", "hypoglycemic", "effects", "in", "vivo"], "h": {"id": "C3538729", "name": "C3538729#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0245514", "name": "C0245514#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "acepromazine", "maleate", ",", "xylazine", "and", "C0936073#ent", "<e1>", "on", "the", "packed", "cell", "volume", "plasma", "protein", ",", "C1366370#ent", "<e2>", "and", "von", "Willebrand", "factor", "antigen", "concentration", "of", "blood", "was", "studied", "in", "normal", "dogs", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366370", "name": "C1366370#ent", "pos": [18, 19]}}
{"token": ["C3889152#ent", "<e1>", "serves", "as", "a", "costimulatory", "molecule", "C1516687#ent", "<e2>"], "h": {"id": "C3889152", "name": "C3889152#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1516687", "name": "C1516687#ent", "pos": [7, 8]}}
{"token": ["These", "results", "suggest", "that", "C0054332#ent", "<e1>", ",", "alone", "or", "combined", "with", "a", "C3536763#ent", "<e2>", ",", "may", "be", "a", "highly", "potent", "antitoxoplasma", "and", "antipneumocystis", "agent", "could", "provide", "major", "pharmacologic", "and", "clinical", "advantages", "available", "agents", "."], "h": {"id": "C0054332", "name": "C0054332#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3536763", "name": "C3536763#ent", "pos": [12, 13]}}
{"token": ["Peripheral", "loperamide", "C0030073#ent", "<e1>", "modulated", "the", "central", "mechanisms", "perception", "of", "C0030193#ent", "<e2>", "stimuli", "."], "h": {"id": "C0030073", "name": "C0030073#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0030193", "name": "C0030193#ent", "pos": [10, 11]}}
{"token": ["However", ",", "the", "reason", "why", "TFE", "and", "C3273420#ent", "<e1>", "are", "more", "effective", "than", "other", "C0001975#ent", "<e2>", "is", "unknown", "."], "h": {"id": "C3273420", "name": "C3273420#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [14, 15]}}
{"token": ["The", "increases", "in", "the", "concentrations", "of", "the", "C0010762#ent", "<e1>", "not", "affected", "by", "loading", "embryos", "ALA", "and", "C1428899#ent", "<e2>", "at", "the", "time", "of", "administration", "of", "the", "inducers", "."], "h": {"id": "C0010762", "name": "C0010762#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1428899", "name": "C1428899#ent", "pos": [16, 17]}}
{"token": ["Sj\u00f6gren's", "syndrome", "also", "be", "proceeding", "--", "without", "demonstrating", "any", "C0035436#ent", "<e1>", "symptoms", "--", "with", "an", "isolated", "C0034069#ent", "<e2>", "as", "it", "had", "been", "evident", "in", "another", "case", "mentioned", "."], "h": {"id": "C0035436", "name": "C0035436#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [16, 17]}}
{"token": ["Food", "intake", "body", "weight", "correlated", "negatively", "to", "C1704950#ent", "<e1>", ",", "but", "not", "C1417815#ent", "<e2>", "in", "PVN", "."], "h": {"id": "C1704950", "name": "C1704950#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [12, 13]}}
{"token": ["We", "hypothesized", "that", ",", "on", "balance", ",", "the", "PPARgamma", "activator", "C0289313#ent", "<e1>", "would", "be", "beneficial", "in", "C0018801#ent", "<e2>", "post-myocardial", "infarction"], "h": {"id": "C0289313", "name": "C0289313#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018801", "name": "C0018801#ent", "pos": [16, 17]}}
{"token": ["The", "regulation", "of", "C1414543#ent", "<e1>", "expression", "may", "be", "associated", "with", "functional", "changes", "in", "C0013765#ent", "<e2>", "development", "and", "growth", "."], "h": {"id": "C1414543", "name": "C1414543#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [13, 14]}}
{"token": ["This", "polymorphism", ",", "absent", "in", "the", "normal", "population", "is", "correlated", "with", "the", "reduction", "of", "C0015528#ent", "<e1>", "activity", "and", "enables", "the", "identification", "of", "C0015530#ent", "<e2>"], "h": {"id": "C0015528", "name": "C0015528#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0015530", "name": "C0015530#ent", "pos": [22, 23]}}
{"token": ["Instead", ",", "the", "protein", "kinase", "CK2", "and", "the", "C1704968#ent", "<e1>", "DPE-specific", "transcription", "in", "an", "in", "vitro", "transcription", "system", "TFIID", ",", "C0127400#ent", "<e2>", ",", "and", "the", "GTFs", "."], "h": {"id": "C1704968", "name": "C1704968#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [20, 21]}}
{"token": ["C1847835#ent", "<e1>", "is", "characterized", "by", "progressive", "C0162835#ent", "<e2>", "from", "an", "autoimmune", "response", "targeting", "epidermal", "melanocytes", "."], "h": {"id": "C1847835", "name": "C1847835#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162835", "name": "C0162835#ent", "pos": [6, 7]}}
{"token": ["Hepcidin", "levels", "are", "reduced", "in", "patients", "with", "C1858664#ent", "<e1>", "due", "to", "mutations", "in", "the", "C3469186#ent", "<e2>", "and", "HJV", "genes", "."], "h": {"id": "C1858664", "name": "C1858664#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3469186", "name": "C3469186#ent", "pos": [14, 15]}}
{"token": ["C0022252#ent", "<e1>", "used", "in", "16", "patients", ",", "nitroglycerin", "in", "36", ",", "C0032906#ent", "<e2>", "in", "24", ",", "and", "captopryl", "in", "20", "patients", "."], "h": {"id": "C0022252", "name": "C0022252#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032906", "name": "C0032906#ent", "pos": [11, 12]}}
{"token": ["C0001175#ent", "<e1>", "AIDS", ")", "in", "childhood", "is", "characterized", "by", "recurrent", "C0004623#ent", "<e2>", "a", "feature", "common", "in", "antibody", "deficiency", "disorders"], "h": {"id": "C0001175", "name": "C0001175#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "are", "specific", "since", "up-regulation", "was", "not", "seen", "for", "other", "C0017337#ent", "<e1>", "associated", "with", "apoptosis", ",", "such", "as", "C0910167#ent", "<e2>", "in", "either", "neurons", "or", "astrocytes", ",", "or", "Bax", "in", "neurons", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0910167", "name": "C0910167#ent", "pos": [19, 20]}}
{"token": ["Three", "C0022173#ent", "<e1>", "were", "observed", "in", "extensor", "digitorum", "longus", "C1447747#ent", "<e2>", ")", ",", "two", "in", "soleus", "(", "SOL", ")", ",", "four", "in", "neonatal", "muscles", "three", "days", "before", "birth", "."], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1447747", "name": "C1447747#ent", "pos": [9, 10]}}
{"token": ["Co-transfection", "and", "immunoblotting", "experiments", "revealed", "that", "dematin", "blocks", "transcriptional", "activation", "Jun", "by", "C1706518#ent", "<e1>", "and", "activates", "C1705524#ent", "<e2>", "via", "a", "C1706518#ent", "<e1>", "independent", "pathway", "."], "h": {"id": "C1706518", "name": "C1706518#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705524", "name": "C1705524#ent", "pos": [16, 17]}}
{"token": ["The", "gravest", "course", "of", "both", "types", "of", "C0011849#ent", "<e1>", "is", "frequently", "encountered", "in", "those", "having", "C1704665#ent", "<e2>", "2", "phenotypes", "and", "slightly", "less", "frequently", "in", "those", "with", "Hp", "1-1"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704665", "name": "C1704665#ent", "pos": [15, 16]}}
{"token": ["C1516119#ent", "<e1>", "and", "erlotinib", "are", "potent", ",", "orally", "administered", "receptor", "tyrosine", "kinase", "inhibitors", "C1413240#ent", "<e2>", "and", "antiangiogenic", "activities"], "h": {"id": "C1516119", "name": "C1516119#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413240", "name": "C1413240#ent", "pos": [13, 14]}}
{"token": ["Because", "surgical", "treatment", "difficult", ",", "and", "outpatient", "radiation", "therapy", "not", "available", "in", "the", "local", "area", "chemotherapy", "with", "C0020402#ent", "<e1>", "combined", "with", "C0011777#ent", "<e2>", "was", "selected", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0011777", "name": "C0011777#ent", "pos": [21, 22]}}
{"token": ["These", "genes", "were", "transcribed", "during", "growth", "on", "C0267964#ent", "<e1>", ",", "with", "11", "of", "the", "genes", "apparently", "in", "an", "C0029073#ent", "<e2>", "yielding", "a", "single", "transcript", "."], "h": {"id": "C0267964", "name": "C0267964#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029073", "name": "C0029073#ent", "pos": [18, 19]}}
{"token": ["Both", "DARPP-32", "and", "its", "truncated", "isoform", "t-DARPP", "were", "C3889446#ent", "<e1>", "in", "colorectal", "adenocarcinoma", "t=2.306", ",", "p=0.028", ")", ",", "while", "C0597715#ent", "<e2>", "was", "more", "frequently", "detected", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0597715", "name": "C0597715#ent", "pos": [19, 20]}}
{"token": ["The", "C0003873#ent", "<e1>", "treated", "with", "prednisone", "and", "C0031990#ent", "<e2>", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0031990", "name": "C0031990#ent", "pos": [7, 8]}}
{"token": ["The", "electrophoretic", "capillary", "filled", "with", "a", "background", "C3536863#ent", "<e1>", "(", "BGE", ")", "containing", "an", "UV", "absorbing", "ion", ":", "C1161334#ent", "<e2>", "BA", ")", "or", "5,5-diethylbarbituric", "acid", "DBA", ")", "."], "h": {"id": "C3536863", "name": "C3536863#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1161334", "name": "C1161334#ent", "pos": [18, 19]}}
{"token": ["This", "report", "describes", "the", "clinical", "and", "C1517495#ent", "<e1>", "two", "large", "and", "unrelated", "families", "with", "C0175697#ent", "<e2>", "Brazil", ",", "emphasizing", "the", "range", "of", "anomalies", "found", "within", "and", "between", "the", "families", "."], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [14, 15]}}
{"token": ["Mixed", "mania", "not", "predict", "different", "maintenance", "response", "C0886883#ent", "<e1>", "or", "lithium", "but", "predicted", "more", "side", "effects", "either", "C1254351#ent", "<e2>", ",", "and", "reduced", "efficacy", "of", "olanzapine", "or", "lamotrigine", "."], "h": {"id": "C0886883", "name": "C0886883#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [17, 18]}}
{"token": ["C1332807#ent", "<e1>", "significantly", "more", "active", "in", "degrading", "GBM", "than", "was", "C3890046#ent", "<e2>", "trypsin", "or", "bacterial", "collagenase"], "h": {"id": "C1332807", "name": "C1332807#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3890046", "name": "C3890046#ent", "pos": [10, 11]}}
{"token": ["Compared", "with", "C1333253#ent", "<e1>", "carriers", ",", "subjects", "homozygous", "for", "the", "C1333252#ent", "<e2>", "poorer", "in", "a", "measure", "of", "general", "cognitive", "functioning", "MMSE", ")", "and", "in", "long", "term", "verbal", "memory", "and", "presented", "reduced", "left", "caudate", "nucleus", "volumes", "."], "h": {"id": "C1333253", "name": "C1333253#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333252", "name": "C1333252#ent", "pos": [10, 11]}}
{"token": ["We", "demonstrate", "direct", "binding", "of", "both", "p66", "family", "members", "C1427861#ent", "<e1>", "as", "well", "as", "C1427862#ent", "<e2>", "."], "h": {"id": "C1427861", "name": "C1427861#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1427862", "name": "C1427862#ent", "pos": [14, 15]}}
{"token": ["C0039543#ent", "<e1>", "blocked", "the", "marked", "fall", "in", "peak", "expiratory", "flow", "arterial", "oxygen", "tension", "in", "the", "C0004096#ent", "<e2>", "subjects", "following", "the", "first", "test", "."], "h": {"id": "C0039543", "name": "C0039543#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [15, 16]}}
{"token": ["To", "further", "examine", "the", "process", "of", "apoptosis", "in", "the", "C0030196#ent", "<e1>", ",", "the", "effects", "of", "4-hydroperoxycyclophosphamide", "exposure", "on", "C0007427#ent", "<e2>", "concentration", "and", "on", "the", "immunolocalization", "of", "cathepsin", "D", "limb", "buds", "assessed", "."], "h": {"id": "C0030196", "name": "C0030196#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [18, 19]}}
{"token": ["The", "convulsions", "continued", "during", "hospitalization", "and", "investigation", "led", "to", "the", "diagnosis", "of", "C0025309#ent", "<e1>", "based", "on", "the", "presence", "of", "C1706005#ent", "<e2>", "anti-CMV", "antibodies"], "h": {"id": "C0025309", "name": "C0025309#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706005", "name": "C1706005#ent", "pos": [19, 20]}}
{"token": ["Platelet", "sensitivity", "C0205911#ent", "<e1>", "was", "studied", "in", "30", "diabetic", "patients", "with", "C0011854#ent", "<e2>", "12", "with", "and", "18", "without", "clinical", "evidence", "vascular", "disease", "in", "10", "healthy", ",", "normal", "volunteers"], "h": {"id": "C0205911", "name": "C0205911#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [11, 12]}}
{"token": ["We", "also", "examined", "whether", "C3811221#ent", "<e1>", "interacts", "with", "selective", "C2911696#ent", "<e2>", "SSRIs", ")", "using", "MDCK", "cells", "expressing", "recombinant", "human", "C3811221#ent", "<e1>", "."], "h": {"id": "C2911696", "name": "C2911696#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811221", "name": "C3811221#ent", "pos": [4, 5]}}
{"token": ["The", "activation", "of", "extracellular", "signal-regulated", "kinase", "ERK", ")", "or", "mitogen-activated", "protein", "kinase", "MAPK", ")", "by", "a", "dual", "specific", "kinase", "C0169101#ent", "<e1>", "(", "MAPK", "or", "C0257151#ent", "<e2>", ",", "is", "a", "critical", "event", "in", "the", "mitogenic", "signal", "transduction", "pathway"], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0257151", "name": "C0257151#ent", "pos": [24, 25]}}
{"token": ["No", "interference", "observed", "from", "other", "accompanying", "drugs", "such", "as", "acetylsalicylic", "acid", "ascorbic", "acid", "betamethasone", ",", "caffeine", ",", "C0009217#ent", "<e1>", "diphenhydramine", ",", "lactose", ",", "C0000970#ent", "<e2>", ",", "and", "prednisolone", "."], "h": {"id": "C0009217", "name": "C0009217#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [23, 24]}}
{"token": ["To", "use", "C1366496#ent", "<e1>", "inhibition", "for", "induction", "of", "ovulation", "in", "women", "in", "whom", "C0086214#ent", "<e2>", "CC", ")", "treatment", "was", "unsuccessful", "."], "h": {"id": "C1366496", "name": "C1366496#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086214", "name": "C0086214#ent", "pos": [13, 14]}}
{"token": ["Wolf-Hirschhorn", "syndrome", "C1710644#ent", "<e1>", ")", ",", "a", "multiple", "congenital", "malformation", "syndrome", "and", "C0796117#ent", "<e2>", "PRDS", ")", ",", "a", "rare", "condition", "with", "similar", "anomalies", ",", "were", "previously", "thought", "to", "be", "clinically", "distinct", "conditions", "."], "h": {"id": "C1710644", "name": "C1710644#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0796117", "name": "C0796117#ent", "pos": [12, 13]}}
{"token": ["Two", "patients", "were", "C0026708#ent", "<e1>", "MPS", "I-S", ")", "and", "one", "was", "suspected", "to", "be", "C0238402#ent", "<e2>", "MPS", "VI", "."], "h": {"id": "C0026708", "name": "C0026708#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0238402", "name": "C0238402#ent", "pos": [14, 15]}}
{"token": ["These", "cases", "were", "classified", "by", "the", "enzyme", "assay", "one", "case", "of", "C0026708#ent", "<e1>", "three", "of", "Hunter", "syndrome", "one", "of", "Sanfilippo", "syndrome", "one", "of", "C0238402#ent", "<e2>"], "h": {"id": "C0026708", "name": "C0026708#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0238402", "name": "C0238402#ent", "pos": [23, 24]}}
{"token": ["These", "barbiturates", "also", "inhibited", "the", "initiators", "of", "the", "MAP", "kinase", "cascade", "the", "C0751984#ent", "<e1>", "rac-1", ",", "and", "prevented", "binding", "to", "their", "partners", "C0812215#ent", "<e2>", "and", "PAK", ",", "respectively", "."], "h": {"id": "C0751984", "name": "C0751984#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [22, 23]}}
{"token": ["We", "examined", "the", "contributions", "of", "the", "C0751984#ent", "<e1>", "Rap", "and", "Ras", "and", "the", "serine-threonine", "kinases", "B-Raf", "C0812215#ent", "<e2>", "to", "the", "activation", "of", "these", "kinases", "in", "human", "islet", "cells"], "h": {"id": "C0751984", "name": "C0751984#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812215", "name": "C0812215#ent", "pos": [16, 17]}}
{"token": ["Breast", "cancer", "patients", "with", "bone", "metastases", "commonly", "treated", "with", "C0729502#ent", "<e1>", "as", "doxorubicin", "and", "C2698656#ent", "<e2>", "control", "their", "bone", "disease"], "h": {"id": "C0729502", "name": "C0729502#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2698656", "name": "C2698656#ent", "pos": [14, 15]}}
{"token": ["Vitiligo", "is", "an", "C0004364#ent", "<e1>", "occurs", "with", "greatly", "increased", "frequency", "in", "the", "rare", "recessive", "autoimmune", "polyendocrinopathy-candidiasis-ectodermal", "dystrophy", "syndrome", "C3714974#ent", "<e2>", ")", "caused", "by", "mutations", "of", "the", "autoimmune", "regulator", "AIRE", ")", "gene", "on", "chromosome", "21q22.3"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3714974", "name": "C3714974#ent", "pos": [18, 19]}}
{"token": ["Gamma-hydroxybutyrate", "(", "GHB", ")", "is", "a", "C0242898#ent", "<e1>", "GABA", ")", "analog", "that", "is", "used", "to", "treat", "C1834372#ent", "<e2>", "but", "that", "is", "also", "abused", "."], "h": {"id": "C0242898", "name": "C0242898#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1834372", "name": "C1834372#ent", "pos": [16, 17]}}
{"token": ["We", "purified", "both", "C0030016#ent", "<e1>", "(", "TsaC", "and", "C1420018#ent", "<e2>", ")", "and", "determined", "their", "molecular", "weights", "N-terminal", "amino", "acid", "sequences"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420018", "name": "C1420018#ent", "pos": [8, 9]}}
{"token": ["A", "high", "molecular", "weight", "anticancer", "agent", "a", "conjugate", "of", "copolymer", "C0065571#ent", "<e1>", "to", "neocarzinostatin", "(", "C0071449#ent", "<e2>", ")", "was", "prepared", "in", "our", "laboratory", "and", "dissolved", "in", "a", "lymphographic", "oily", "contrast", "medium", "Lipiodol", "(", "SMANCS/Lipiodol", ")", "."], "h": {"id": "C0065571", "name": "C0065571#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0071449", "name": "C0071449#ent", "pos": [15, 16]}}
{"token": ["Pyruvate", "decarboxylase", "C1418706#ent", "<e1>", ")", "contains", "thiamine", "pyrophosphate", "TPP", ")", "and", "C1417500#ent", "<e2>", "+", "as", "cofactors", "."], "h": {"id": "C1418706", "name": "C1418706#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [11, 12]}}
{"token": ["C0126347#ent", "<e1>", "was", "effective", "as", "an", "appetite", "suppressant", "lower", "doses", "C0033798#ent", "<e2>", ",", "amphetamine", ",", "fenfluramine", ",", "naltrexone", "and", "nalmefene", "."], "h": {"id": "C0126347", "name": "C0126347#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [10, 11]}}
{"token": ["The", "suppressive", "effect", "the", "macrophages", "was", "not", "counteracted", "by", "C0021246#ent", "<e1>", ",", "a", "potent", "inhibitor", "of", "prostaglandin", "synthesis", "or", "C0007367#ent", "<e2>", ",", "a", "catabolic", "enzyme", "hydrogen", "peroxide", "H2O2", ")", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [19, 20]}}
{"token": ["Heme", "oxygenase-1", "a", "key", "C0014442#ent", "<e1>", "in", "heme", "catabolism", ",", "and", "C1533698#ent", "<e2>", "iNOS", ")", "are", "responsible", "for", "production", "of", "carbon", "monoxide", "nitric", "oxide", "NO", ")", ",", "respectively", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [11, 12]}}
{"token": ["Limb", "girdle", "muscular", "dystrophy", "type", "2A", "LGMD2A", ")", "is", "caused", "by", "single", "or", "small", "nucleotide", "changes", "widespread", "along", "the", "C1413113#ent", "<e1>", "gene", ",", "which", "encodes", "the", "C0030940#ent", "<e2>", "calpain-3", "."], "h": {"id": "C1413113", "name": "C1413113#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [26, 27]}}
{"token": ["The", "C1334133#ent", "<e1>", "preparations", "were", "subjected", "to", "sodium", "dodecyl", "sulfate", "C0272170#ent", "<e2>", ")", "polyacrylamide", "gel", "electrophoresis", "reducing", "or", "nonreducing", "conditions", "."], "h": {"id": "C1334133", "name": "C1334133#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [10, 11]}}
{"token": ["C0005064#ent", "<e1>", "inhibited", "in", "a", "differential", "degree", "the", "C0074059#ent", "<e2>", "activities", "for", "morphine", "and", "aminopyrine", "N-demethylation", "as", "well", "as", "glucuronyltransferase", "activity", "morphine", "."], "h": {"id": "C0005064", "name": "C0005064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0074059", "name": "C0074059#ent", "pos": [8, 9]}}
{"token": ["Studies", "with", "inhibitors", "and", "dominant", "negative", "expression", "plasmids", "that", "E2", "activates", "C1332719#ent", "<e1>", "expression", "through", "activation", "of", "genomic", "ERalpha/Sp1", "and", "C1705438#ent", "<e2>", "and", "cAMP-dependent", "activation", "of", "NF-YA", "."], "h": {"id": "C1332719", "name": "C1332719#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705438", "name": "C1705438#ent", "pos": [20, 21]}}
{"token": ["A", "second", "treatment", "with", "PMA", "or", "thrombin", ",", "48", "hrs", "after", "cells", "had", "been", "stimulated", "with", "these", "C0991617#ent", "<e1>", ",", "resulted", "again", "in", "the", "instantaneous", "release", "of", "C1336938#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1336938", "name": "C1336938#ent", "pos": [27, 28]}}
{"token": ["Desensitization", "of", "C0033634#ent", "<e1>", "performed", "by", "incubation", "of", "C1332684#ent", "<e2>", "1", "microM", "phorbol", "ester", "24", "h.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332684", "name": "C1332684#ent", "pos": [8, 9]}}
{"token": ["We", "report", "a", "35-year-old", "Japanese", "female", "patient", "with", "ovarian", "dysgerminoma", "elevated", "serum", "levels", "of", "placental", "alkaline", "phosphatase", "PLAP", ")", ",", "C1880904#ent", "<e1>", "NSE", ")", "and", "prolactin", "(", "C1418938#ent", "<e2>", ")", "."], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [27, 28]}}
{"token": ["Electrical", "stimulations", "regions", "of", "C0001614#ent", "<e1>", "projecting", "to", "the", "lateral", "suprasylvian", "area", "(", "C0023652#ent", "<e2>", ")", "were", "accompanied", "by", "enhanced", "levels", "of", "release", "of", "excitatory", "amino", "acids"], "h": {"id": "C0001614", "name": "C0001614#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0023652", "name": "C0023652#ent", "pos": [13, 14]}}
{"token": ["The", "structures", "of", "C1609899#ent", "<e1>", "eglin", "c", "both", "potent", "inhibitors", "of", "human", "C0064833#ent", "<e2>", "cathepsin", "G", "were", "compared", "by", "micro", "amino-acid", "analysis", "and", "peptide", "mapping", "techniques"], "h": {"id": "C1609899", "name": "C1609899#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [12, 13]}}
{"token": ["A", "novel", "C0597298#ent", "<e1>", "of", "Cbl-associated", "protein", "CAP", ")", "was", "identified", "in", "a", "yeast", "two-hybrid", "screen", "C1412312#ent", "<e2>", "expressed", "in", "the", "heart", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412312", "name": "C1412312#ent", "pos": [16, 17]}}
{"token": ["C0242422#ent", "<e1>", "a", "highly", "controversial", "concept", "since", "its", "first", "description", "by", "C0393576#ent", "<e2>", "in", "1929", "."], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0393576", "name": "C0393576#ent", "pos": [11, 12]}}
{"token": ["The", "effects", "of", "endothelins", "(", "C3273436#ent", "<e1>", "and", "ET-3", ")", "were", "investigated", "using", "C0030903#ent", "<e2>", ")", ",", "strychnine-", "(", "STR", ")", ",", "picrotoxin-", "(", "PIC", ")", "and", "bicuculline-induced", "(", "BIC", ")", "convulsions", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030903", "name": "C0030903#ent", "pos": [13, 14]}}
{"token": ["Injection", "of", "a", "sublethal", "dose", "of", "plancitoxin", "I", "or", "C3273406#ent", "<e1>", "into", "mice", "remarkably", "elevated", "serum", "levels", "of", "glutamic", "oxaloacetic", "transaminase", "C0001899#ent", "<e2>", "demonstrating", "that", "both", "toxins", "are", "potently", "hepatotoxic", "."], "h": {"id": "C3273406", "name": "C3273406#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001899", "name": "C0001899#ent", "pos": [21, 22]}}
{"token": ["Analysis", "of", "the", "genomic", "context", "genes", "encoding", "PduO", "and", "related", "proteins", "indicated", "that", "particular", "C0024750#ent", "<e1>", "tend", "to", "be", "specialized", "for", "particular", "AdoCbl-dependent", "C3541394#ent", "<e2>", "or", "for", "the", "de", "novo", "synthesis", "of", "AdoCbl", "."], "h": {"id": "C0024750", "name": "C0024750#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [23, 24]}}
{"token": ["The", "PUT1", "gene", "Saccharomyces", "cerevisiae", "believed", "to", "encode", "C1418945#ent", "<e1>", "has", "been", "completely", "sequenced", "and", "contains", "an", "C1412821#ent", "<e2>", "of", "encoding", "a", "polypeptide", "of", "476", "amino", "acids", "length", "."], "h": {"id": "C1418945", "name": "C1418945#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412821", "name": "C1412821#ent", "pos": [17, 18]}}
{"token": ["Combination", "therapy", "estramustine", "plus", "taxanes", ",", "other", "C0003379#ent", "<e1>", "or", "other", "C0035064#ent", "<e2>", "such", "as", "topoisomerase", "II", "inhibitors", "has", "been", "found", "to", "cause", "shrinkage", "of", "measurable", "soft", "tissue", "disease", "diminution", "of", "serum", "PSA", "levels", "."], "h": {"id": "C0003379", "name": "C0003379#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [11, 12]}}
{"token": ["Additionally", ",", "C3811170#ent", "<e1>", "(", "60", "mg/kg", ")", "could", "inhibit", "C1968833#ent", "<e2>", "expression", "in", "both", "models", "."], "h": {"id": "C3811170", "name": "C3811170#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1968833", "name": "C1968833#ent", "pos": [10, 11]}}
{"token": ["C1415329#ent", "<e1>", "GST", ")", "M1", "and", "C2347263#ent", "<e2>", "GST", "enzymes", ",", "and", "are", "polymorphic", "in", "humans", "."], "h": {"id": "C1415329", "name": "C1415329#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2347263", "name": "C2347263#ent", "pos": [6, 7]}}
{"token": ["The", "biosynthesis", "of", "fatty", "acids", "sterols", "from", "C0000979#ent", "<e1>", ",", "and", "of", "triacylglycerols", "and", "C0597522#ent", "<e2>", "palmitate", "was", "markedly", "augmented", "in", "the", "deficient", "cells"], "h": {"id": "C0000979", "name": "C0000979#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0597522", "name": "C0597522#ent", "pos": [14, 15]}}
{"token": ["Binding", "of", "a", "hydrophobic", "probe", "C1120034#ent", "<e1>", "(", "TNS", ")", ",", "to", "C4283758#ent", "<e2>", ",", "r-HDLs", "and", "apoHDL", "were", "evaluated", "on", "the", "basis", "of", "Halfman", "and", "Nishida", "'s", "method", "."], "h": {"id": "C1120034", "name": "C1120034#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4283758", "name": "C4283758#ent", "pos": [12, 13]}}
{"token": ["The", "present", "study", "aimed", "to", "elucidate", "the", "distribution", "of", "C0018969#ent", "<e1>", "HO-1", ")", "in", "the", "hippocampus", "after", "intracerebroventricular", "injections", "of", "C0205812#ent", "<e2>", "."], "h": {"id": "C0018969", "name": "C0018969#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [20, 21]}}
{"token": ["Although", "C0221014#ent", "<e1>", "RA", "patients", "is", "rarely", "complicated", "with", "C0001339#ent", "<e2>", "C0001339#ent", "<e2>", "such", "cases", "could", "be", "severe", "and", "intractable", "and", "might", "result", "in", "a", "fatal", "outcome", "."], "h": {"id": "C0221014", "name": "C0221014#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [9, 10]}}
{"token": ["Both", "wild-type", "FKBP12", "and", "an", "C1414618#ent", "<e1>", "mutant", "with", "reduced", "C0022202#ent", "<e2>", "supported", "mdr3", "function", "."], "h": {"id": "C1414618", "name": "C1414618#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022202", "name": "C0022202#ent", "pos": [10, 11]}}
{"token": ["Heightened", "threats", "of", "epidemics", "prevailed", "in", "that", "area", ",", "and", "C0030528#ent", "<e1>", "trachoma", ",", "tuberculois", "and", "C0036918#ent", "<e2>", "serious", "health", "problems"], "h": {"id": "C0030528", "name": "C0030528#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0036918", "name": "C0036918#ent", "pos": [16, 17]}}
{"token": ["p67", ",", "a", "cellular", "glycoprotein", "protects", "eIF2", "alpha", "phosphorylation", "by", "inhibitory", "C0031727#ent", "<e1>", "such", "as", "C3710914#ent", "<e2>", "and", "HCR", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3710914", "name": "C3710914#ent", "pos": [15, 16]}}
{"token": ["Topoisomerase", "IIalpha", "topoIIalpha", ")", "is", "an", "essential", "C1333402#ent", "<e1>", "regulating", "DNA", "structure", "cell", "proliferation", "is", "encoded", "by", "the", "C0256022#ent", "<e2>", "."], "h": {"id": "C1333402", "name": "C1333402#ent", "pos": [7, 8]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0256022", "name": "C0256022#ent", "pos": [18, 19]}}
{"token": ["Defects", "in", "tetrahydrobiopterin", "and", "a", "deficiency", "of", "aromatic", "L-amino", "acid", "decarboxylase", "C1420718#ent", "<e1>", "dopamine-beta-hydroxylase", "are", "candidate", "inborn", "errors", "C0243051#ent", "<e2>", "metabolites", "screening", "."], "h": {"id": "C1420718", "name": "C1420718#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0243051", "name": "C0243051#ent", "pos": [18, 19]}}
{"token": ["The", "yield", "of", "C0024054#ent", "<e1>", "per", "liver", "following", "C1337113#ent", "<e2>", "treatment", "corresponded", "to", "a", "10", "-", "50-fold", "increase", "as", "compared", "to", "normal", "mice"], "h": {"id": "C0024054", "name": "C0024054#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1337113", "name": "C1337113#ent", "pos": [8, 9]}}
{"token": ["At", "the", "highest", "dose", "of", "C0772125#ent", "<e1>", "(", "200", "mg/kg", ")", ",", "the", "immunostain", "for", "C1364818#ent", "<e2>", "and", "caspase-3", "was", "returned", "to", "normal", "levels", "."], "h": {"id": "C0772125", "name": "C0772125#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1364818", "name": "C1364818#ent", "pos": [15, 16]}}
{"token": ["Several", "recent", "reports", "have", "described", "C0036572#ent", "<e1>", "in", "patients", "with", "C0007570#ent", "<e2>", "and", "in", "some", ",", "folic", "acid", "deficiency", "brain", "calcifications"], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [10, 11]}}
{"token": ["Before", "C3887648#ent", "<e1>", "infusion", "myocardial", "adenosine", "and", "without", "C0002575#ent", "<e2>", "was", "12.7", "and", "14.3", "nmol/g", "dry", "wt", ",", "respectively", "(", "P", "greater", "than", "0.05", ")", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [8, 9]}}
{"token": ["The", "direct", "effects", "of", "C3887648#ent", "<e1>", ",", "epinephrine", ",", "isoproterenol", ",", "C0002575#ent", "<e2>", ",", "dopamine", "and", "papaverine", "on", "coronary", "blood", "flow", "oxygen", "consumption", "examined", "in", "an", "isolated", "heart-lung", "preparation"], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [11, 12]}}
{"token": ["infusion", "of", "either", "C3887648#ent", "<e1>", ",", "isoproterenol", ",", "or", "C0002575#ent", "<e2>", ",", "this", "effect", "was", "probably", "of", "hemodynamic", "origin", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0002575", "name": "C0002575#ent", "pos": [9, 10]}}
{"token": ["These", "forms", "of", "C3540820#ent", "<e1>", "together", "with", "C1442484#ent", "<e2>", "all", "capable", "of", "inactivating", "C3b", "to", "C3bi", "."], "h": {"id": "C3540820", "name": "C3540820#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1442484", "name": "C1442484#ent", "pos": [7, 8]}}
{"token": ["Non-competitive", "N-methyl-D-aspartate", "receptor", "antagonists", ",", "including", "phencyclidine", ",", "C0022614#ent", "<e1>", ",", "and", "MK801", ",", "produce", "vacuoles", "and", "induce", "the", "C0034152#ent", "<e2>", "stress", "gene", "layer", "III", "pyramidal", "neurons", "of", "the", "rat", "cingulate", "cortex"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [19, 20]}}
{"token": ["In", "these", "series", ",", "C0007034#ent", "<e1>", "presaturated", "at", "-24", "hours", "with", "C0013227#ent", "<e2>", "to", "remove", "a", "possible", "route", "for", "loss", "of", "drug", "sclera", ",", "that", "of", "the", "systemic", "circulation", "the", "high", "concentration", "of", "carbonic", "anhydrase", "red", "cells"], "h": {"id": "C0007034", "name": "C0007034#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [11, 12]}}
{"token": ["S-nitrosylation", "after", "agonist", "stimulation", "of", "the", "beta-adrenergic", "receptor", "a", "prototypical", "GPCR", ",", "dissociates", "C1328053#ent", "<e1>", "from", "C1412552#ent", "<e2>", "promotes", "binding", "of", "C1412552#ent", "<e2>", "clathrin", "heavy", ",", "thereby", "accelerating", "receptor", "internalization", "."], "h": {"id": "C1328053", "name": "C1328053#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1412552", "name": "C1412552#ent", "pos": [16, 17]}}
{"token": ["The", "aims", "of", "the", "study", "were", "to", "describe", "and", "compare", "the", "frequency", "and", "nature", "of", "histologically", "detectable", "C0206064#ent", "<e1>", "patients", "with", "various", "connective", "tissue", "diseases", "C1442905#ent", "<e2>", ")", "."], "h": {"id": "C0206064", "name": "C0206064#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1442905", "name": "C1442905#ent", "pos": [25, 26]}}
{"token": ["Each", "of", "PR", ",", "mescaline", "(", "C4283758#ent", "<e1>", ")", "and", "its", "derivatives", "gave", "almost", "the", "same", "C1839576#ent", "<e2>", "values", "for", "TMQ", "and", "ISO", "."], "h": {"id": "C4283758", "name": "C4283758#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1839576", "name": "C1839576#ent", "pos": [16, 17]}}
{"token": ["Both", "C3540017#ent", "<e1>", "were", "localized", "on", "isoelectric", "focusing", "gels", "and", "C0001057#ent", "<e2>", "was", "also", "demonstrated", "in", "an", "immunoprecipitate", "of", "DF1", "."], "h": {"id": "C3540017", "name": "C3540017#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0001057", "name": "C0001057#ent", "pos": [10, 11]}}
{"token": ["The", "most", "important", "of", "these", "are", "cutaneous", "leishmaniasis", "cutaneous", "amoebiasis", "tinea", "imbricata", "C0040254#ent", "<e1>", ",", "sporotrichosis", ",", "chromomycosis", ",", "C0041309#ent", "<e2>", "Buruli", "ulcer", "cutaneous", "larva", "migrans", "dracontiasis", "."], "h": {"id": "C0040254", "name": "C0040254#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041309", "name": "C0041309#ent", "pos": [19, 20]}}
{"token": ["C1335833#ent", "<e1>", "and", "AAC2", "genes", "in", "yeast", "each", "encode", "functional", "C1335833#ent", "<e1>", "AAC", ")", "proteins", "of", "the", "mitochondrial", "inner", "membrane"], "h": {"id": "C1335833", "name": "C1335833#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335833", "name": "C1335833#ent", "pos": [0, 1]}}
{"token": ["Moreover", ",", "epidermal", "growth", "factor", "treatment", "of", "COS-7", "cells", "co-localization", "of", "PACSIN", "1", "and", "C1420314#ent", "<e1>", "in", "actin-rich", "membrane", "ruffles", "and", "their", "interaction", "is", "regulated", "through", "C1367721#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C1420314", "name": "C1420314#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [26, 27]}}
{"token": ["4-S-cysteinylphenol", "(", "4-S-CP", ")", ",", "the", "C1334043#ent", "<e1>", "tyrosine", ",", "has", "been", "recently", "synthesized", "as", "a", "selective", "C0729502#ent", "<e2>", "malignant", "melanoma", "has", "been", "shown", "to", "be", "a", "specific", "substrate", "for", "tyrosinase", "in", "vitro"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [17, 18]}}
{"token": ["The", "most", "common", "clinical", "toxicities", "C0812246#ent", "<e1>", "consisted", "of", "C0424790#ent", "<e2>", ",", "anorexia", ",", "headache", ",", "and", "fatigue", "."], "h": {"id": "C0812246", "name": "C0812246#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0424790", "name": "C0424790#ent", "pos": [9, 10]}}
{"token": ["His", "C0002878#ent", "<e1>", "is", "moderate", "to", "mild", "and", "aggravated", "by", "C0041912#ent", "<e2>"], "h": {"id": "C0002878", "name": "C0002878#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0041912", "name": "C0041912#ent", "pos": [10, 11]}}
{"token": ["The", "coxsackie", "homology", "was", "in", "C3539946#ent", "<e1>", "-", "266", "and", "the", "C0001486#ent", "<e2>", "homology", "was", "in", "C3539946#ent", "<e1>", "-", "524", "of", "GAD65", "."], "h": {"id": "C0001486", "name": "C0001486#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539946", "name": "C3539946#ent", "pos": [5, 6]}}
{"token": ["To", "shed", "light", "on", "the", "activity", "and", "regulation", "of", "C1706023#ent", "<e1>", "and", "related", "C1421249#ent", "<e2>", "we", "expressed", "and", "purified", "C1706023#ent", "<e1>", "using", "the", "Sf9/baculovirus", "system", "."], "h": {"id": "C1421249", "name": "C1421249#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1706023", "name": "C1706023#ent", "pos": [9, 10]}}
{"token": ["Sulfonamides", "tested", "in", "an", "agar", "dilution", "method", "sulfachloropyridazine", ",", "sulfadiazine", ",", "sulfadimethoxine", ",", "sulfamethazine", ",", "C0700599#ent", "<e1>", ",", "sulfisoxazole", ",", "sulfamerazine", ",", "sulfamethoxazole", ",", "C0038683#ent", "<e2>", ",", "sulfanilamide", ",", "sulfatroxazole", ",", "and", "sulfisomidine", "."], "h": {"id": "C0700599", "name": "C0700599#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0038683", "name": "C0038683#ent", "pos": [24, 25]}}
{"token": ["The", "levels", "of", "both", "thymidylate", "synthase", "C0039667#ent", "<e1>", "relatively", "constant", "during", "cell", "cycle", "transit", "following", "release", "from", "the", "C1516035#ent", "<e2>", "blockade", "."], "h": {"id": "C0039667", "name": "C0039667#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1516035", "name": "C1516035#ent", "pos": [18, 19]}}
{"token": ["The", "formation", "of", "duplications", "and", "deletions", "was", "demonstrated", "in", "the", "his", "C0022895#ent", "<e1>", "using", "insertions", "of", "C4048826#ent", "<e2>", "8", "(", "a", "transposition-defective", "Mud-lac", "phage", ")", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4048826", "name": "C4048826#ent", "pos": [16, 17]}}
{"token": ["Injection", "of", "MPG", "after", "C0729078#ent", "<e1>", "helps", "to", "maintain", "the", "higher", "C1260386#ent", "<e2>", "level", "for", "a", "longer", "duration", "compared", "to", "treatment", "with", "C0729078#ent", "<e1>", "alone", "."], "h": {"id": "C0729078", "name": "C0729078#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1260386", "name": "C1260386#ent", "pos": [11, 12]}}
{"token": ["While", "catalase", "activity", "significantly", "(", "P", "<", "0.05", ")", "elevated", "in", "soleus", "and", "extensor", "digitorum", "longus", "muscles", "from", "C2985443#ent", "<e1>", "deactivated", "mice", ",", "C0038838#ent", "<e2>", "glutathione", "peroxidase", "activities", "were", "not", "."], "h": {"id": "C2985443", "name": "C2985443#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0038838", "name": "C0038838#ent", "pos": [23, 24]}}
{"token": ["The", "AAV", "vector", "encoding", "C0015278#ent", "<e1>", "hGAA", ")", "was", "cloned", "into", "an", "C2239387#ent", "<e2>", ",", "polymerase/preterminal", "protein-deleted", "adenovirus", ",", "such", "that", "it", "is", "packaged", "as", "an", "Ad", "vector"], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2239387", "name": "C2239387#ent", "pos": [12, 13]}}
{"token": ["Importantly", ",", "protease", "pathways", "represent", "prominent", "mechanisms", "in", "neurodegenerative", "diseases", "especially", "C0002395#ent", "<e1>", ",", "Huntington", ",", "and", "C0242422#ent", "<e2>"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [17, 18]}}
{"token": ["The", "injected", "C3710940#ent", "<e1>", "oxidoreduction", "at", "C-20", "and", "16", "C0599930#ent", "<e2>", "."], "h": {"id": "C3710940", "name": "C3710940#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0599930", "name": "C0599930#ent", "pos": [9, 10]}}
{"token": ["The", "oxidation", "of", "VA", "to", "veratryl", "aldehyde", "C3889123#ent", "<e1>", "was", "inhibited", "by", "C0031381#ent", "<e2>", "."], "h": {"id": "C3889123", "name": "C3889123#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031381", "name": "C0031381#ent", "pos": [12, 13]}}
{"token": ["In", "conclusion", ",", "C1417104#ent", "<e1>", "patients", "had", "lower", "BMC", ",", "C1414083#ent", "<e2>", "and", "z-scores", "than", "a", "control", "group"], "h": {"id": "C1417104", "name": "C1417104#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414083", "name": "C1414083#ent", "pos": [10, 11]}}
{"token": ["C1335056#ent", "<e1>", "is", "a", "ubiquitously", "expressed", "intracellular", "C1335554#ent", "<e2>", "PTP", ")", "that", "has", "been", "implicated", "in", "the", "negative", "regulation", "of", "insulin", "signaling"], "h": {"id": "C1335056", "name": "C1335056#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [7, 8]}}
{"token": ["There", "is", "no", "C0001623#ent", "<e1>", "APS-III", "which", "includes", "C0677607#ent", "<e2>", "type", "1", "diabetes", "and", "other", "autoimmune", "extra-endocrine", "processes", "(", "like", "pernicious", "anemia", "vitiligo", ")", "."], "h": {"id": "C0001623", "name": "C0001623#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0677607", "name": "C0677607#ent", "pos": [8, 9]}}
{"token": ["The", "C1420193#ent", "<e1>", "patients", "with", "non-insulin", "dependent", "diabetes", "mellitus", "treated", "with", "C0770893#ent", "<e2>", "were", "more", "fluid", "than", "those", "from", "non-insulin", "dependent", "diabetes", "mellitus", "patients", "treated", "by", "diet", "or", "healthy", "controls"], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0770893", "name": "C0770893#ent", "pos": [11, 12]}}
{"token": ["Eflornithine", "(", "C0282042#ent", "<e1>", ";", "DFMO", ")", "is", "a", "recently", "developed", "drug", "against", "C0041228#ent", "<e2>", "sleeping", "sickness", "."], "h": {"id": "C0282042", "name": "C0282042#ent", "pos": [2, 3]}, "relation": "may_treat", "t": {"id": "C0041228", "name": "C0041228#ent", "pos": [13, 14]}}
{"token": ["Moreover", ",", "activation", "of", "ERKs", "and", "C0257535#ent", "<e1>", "not", "required", "for", "the", "up-regulation", "of", "PAF-AH", "(", "C3273406#ent", "<e2>", ")", "in", "differentiated", "macrophages"], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3273406", "name": "C3273406#ent", "pos": [16, 17]}}
{"token": ["We", "demonstrate", "that", "the", "C3536831#ent", "<e1>", "phenylephrine", ",", "induces", "C0034152#ent", "<e2>", "expression", "in", "brown", "adipose", "tissue", "BAT", ")", "."], "h": {"id": "C3536831", "name": "C3536831#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034152", "name": "C0034152#ent", "pos": [9, 10]}}
{"token": ["C0029089#ent", "<e1>", "described", "in", "an", "eight-year-old", "boy", "with", "C0936251#ent", "<e2>", "."], "h": {"id": "C0029089", "name": "C0029089#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0936251", "name": "C0936251#ent", "pos": [8, 9]}}
{"token": ["The", "changes", "of", "lipid", "peroxidation", "thiol", "disulfide", "equilibrium", ",", "glucoso-6-phosphate", "dehydrogenase", "C0007367#ent", "<e1>", "and", "superoxide", "dismutase", "activity", "under", "influence", "of", "immunostimulants", "during", "C0070054#ent", "<e2>", "inhalation", "were", "studied", "."], "h": {"id": "C0007367", "name": "C0007367#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0070054", "name": "C0070054#ent", "pos": [22, 23]}}
{"token": ["Inhibition", "of", "MEK1/2", "but", "not", "C2936824#ent", "<e1>", "p38", "kinase", "JNK", "abolished", "quercetin-induced", "phosphorylation", "of", "C1623430#ent", "<e2>", ",", "cleavage", "of", "caspase-3", "and", "-7", ",", "cleavage", "of", "PARP", "and", "apoptosis", "."], "h": {"id": "C2936824", "name": "C2936824#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [14, 15]}}
{"token": ["Past", "medical", "therapy", "C3203102#ent", "<e1>", "the", "use", "of", "C0006683#ent", "<e2>", "acute", "vasoreactive", "subjects", "and", "oral", "anticoagulants", "continuous", "intravenous", "administration", "epoprostenol", "in", "the", "more", "severe", "cases", "."], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0006683", "name": "C0006683#ent", "pos": [8, 9]}}
{"token": ["We", "describe", "a", "9-year-old", "girl", "with", "classical", "features", "of", "C0175702#ent", "<e1>", "presented", "with", "C0042928#ent", "<e2>", "which", "no", "other", "cause", "was", "found", "."], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0042928", "name": "C0042928#ent", "pos": [13, 14]}}
{"token": ["The", "C1419619#ent", "<e1>", "values", "of", "CP-060S", ",", "CP-060R", "and", "C0012373#ent", "<e2>", "were", "9.16", "+", "/-", "0.18", ",", "8.24", "+", "/-", "0.14", "and", "7.66", "+", "/-", "0.09", ",", "respectively", "."], "h": {"id": "C1419619", "name": "C1419619#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0012373", "name": "C0012373#ent", "pos": [9, 10]}}
{"token": ["The", "adhesion", "of", "human", "peripheral", "lymphocytes", "C3538683#ent", "<e1>", ")", "was", "studied", "after", "preadsorption", "of", "fibronectin", "(", "C1706331#ent", "<e2>", ")", "and", "vitronectin", "(", "VN", ")", "on", "hydrophilic", "glass", "and", "hydrophobic", "octadecyl", "glass", "."], "h": {"id": "C3538683", "name": "C3538683#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706331", "name": "C1706331#ent", "pos": [16, 17]}}
{"token": ["In", "conclusion", ",", "parenteral", "high-dose", "methotrexate", "and", "C4082693#ent", "<e1>", "are", "the", "only", "two", "C0035064#ent", "<e2>", "with", "well-demonstrated", "published", "efficacy", "in", "psoriatic", "arthritis"], "h": {"id": "C4082693", "name": "C4082693#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [13, 14]}}
{"token": ["The", "human", "C1413354#ent", "<e1>", "cDNA", "suppressed", "the", "growth", "defect", "nas1", "disruptant", "cells", ",", "when", "expressed", "from", "single-copy", "or", "multi-copy", "vectors", ",", "indicating", "that", "C1413354#ent", "<e1>", "is", "functionally", "equivalent", "to", "yeast", "C1537502#ent", "<e1>", "."], "h": {"id": "C1413354", "name": "C1413354#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [30, 31]}}
{"token": ["C1419631#ent", "<e1>", "is", "one", "of", "the", "most", "conserved", "C1539696#ent", "<e2>", "appears", "to", "have", "a", "central", "role", "the", "ribonucleoprotein", "complex"], "h": {"id": "C1419631", "name": "C1419631#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [8, 9]}}
{"token": ["Exposure", "of", "female", "rats", "for", "48", "h", "to", "physiologically", "relevant", "doses", "of", "oestrogen", "attenuates", "beta-adrenoceptor", "function", "the", "C0813171#ent", "<e1>", "and", "POA", "as", "indicated", "by", "reduced", "C0282210#ent", "<e2>", "(", "beta-adrenoceptor", "agonist)", "stimulation", "of", "adenylyl", "cyclase", "."], "h": {"id": "C0813171", "name": "C0813171#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [25, 26]}}
{"token": ["Future", "experiments", "are", "focused", "on", "the", "regulation", "of", "C3810625#ent", "<e1>", "expression", "by", "C0012177#ent", "<e2>", "which", "could", "be", "important", "for", "body-weight", "management", "."], "h": {"id": "C3810625", "name": "C3810625#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012177", "name": "C0012177#ent", "pos": [12, 13]}}
{"token": ["The", "action", "of", "methadone-mediated", "uncoupling", "of", "the", "receptor", "from", "the", "C0060916#ent", "<e1>", "blocked", "by", "the", "C1449702#ent", "<e2>", ")", ",", "but", "not", "by", "the", "specific", "protein", "kinase", "C", "inhibitor", "chelerythrine", "."], "h": {"id": "C0060916", "name": "C0060916#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1449702", "name": "C1449702#ent", "pos": [15, 16]}}
{"token": ["Altogether", ",", "the", "data", "suggest", "a", "complex", "type", "of", "involvement", "of", "C1428430#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0151744#ent", "<e2>"], "h": {"id": "C1428430", "name": "C1428430#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0151744", "name": "C0151744#ent", "pos": [17, 18]}}
{"token": ["C0054846#ent", "<e1>", "both", "sources", "phosphorylates", "the", "same", "subunits", "of", "C0035679#ent", "<e2>", "an", "identical", "set", "of", "proteins", "in", "a", "complex", "mixture", "of", "acid-soluble", "proteins", "Drosophila", "tissue", "culture", "cells"], "h": {"id": "C0054846", "name": "C0054846#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035679", "name": "C0035679#ent", "pos": [9, 10]}}
{"token": ["C0002842#ent", "<e1>", "treatment", "abrogated", "the", "increases", "in", "nuclear", "AR", "content", "and", "BrdU", "C1420713#ent", "<e2>", ",", "and", "prevented", "immunohistochemical", "staining"], "h": {"id": "C0002842", "name": "C0002842#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1420713", "name": "C1420713#ent", "pos": [12, 13]}}
{"token": ["Vitamin", "deficiencies", "especially", "vitamin", "B6", "C3538796#ent", "<e1>", "and", "folates", ",", "and", "C0175683#ent", "<e2>", "vitamins", "E", "C", ")", "could", "also", "influence", "the", "memory", "capabilities", "and", "have", "an", "effect", "on", "cognitive", "decline"], "h": {"id": "C3538796", "name": "C3538796#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0175683", "name": "C0175683#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "may", "suggest", "a", "control", "role", "for", "C1334077#ent", "<e1>", "in", "hepatocyte", "priming", ",", "through", "a", "C1826756#ent", "<e2>", "dissociation-independent", "regulation", "of", "c-myc", "."], "h": {"id": "C1334077", "name": "C1334077#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1826756", "name": "C1826756#ent", "pos": [16, 17]}}
{"token": ["For", "patients", "with", "C0003873#ent", "<e1>", "a", "review", "of", "several", "trials", "found", "C0016377#ent", "<e2>", "often", "superior", "to", "aspirin", "and", "naproxen", ",", "and", "equivalent", "to", "indomethacin", "and", "ibuprofen", "in", "efficacy", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0016377", "name": "C0016377#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "the", "presence", "of", "the", "C0013570#ent", "<e1>", "protein", "results", "in", "a", "down-regulation", "of", "IE62", "activation", "in", "C0662453#ent", "<e2>", "rat", "neuronal", "cells"], "h": {"id": "C0013570", "name": "C0013570#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0662453", "name": "C0662453#ent", "pos": [18, 19]}}
{"token": ["We", "estimated", "the", "effect", "of", "atorvastatin", "and", "C0246203#ent", "<e1>", "on", "plasma", "antioxidative", "activity", "in", "C1956346#ent", "<e2>", "CHD", ")", "primary", "prevention"], "h": {"id": "C0246203", "name": "C0246203#ent", "pos": [7, 8]}, "relation": "may_prevent", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [14, 15]}}
{"token": ["The", "flow", "rate-mediated", "increase", "in", "perfusion", "pressure", "significantly", "enhanced", "by", "N(G)-nitro-L-arginine", "(", "L-NOARG", ")", "plus", "methylene", "blue", "C1417048#ent", "<e1>", ")", "and", "slightly", "enhanced", "by", "treatment", "with", "C0076252#ent", "<e2>", "(", "TEA", ")", "."], "h": {"id": "C1417048", "name": "C1417048#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0076252", "name": "C0076252#ent", "pos": [26, 27]}}
{"token": ["Familial", "chylomicronemia", "an", "autosomal", "recessive", "disease", "by", "fasting", "C0542037#ent", "<e1>", "and", "an", "absence", "of", "lipoprotein", "lipase", "C0023816#ent", "<e2>", ")", "activity", "in", "post-heparin", "plasma", "."], "h": {"id": "C0542037", "name": "C0542037#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0023816", "name": "C0023816#ent", "pos": [16, 17]}}
{"token": ["C1418938#ent", "<e1>", "is", "an", "anterior", "pituitary", "hormone", ",", "along", "with", "GH", "and", "C0030360#ent", "<e2>", ",", "forms", "a", "family", "of", "hormones", "that", "probably", "resulted", "from", "the", "duplication", "of", "an", "ancestral", "gene", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030360", "name": "C0030360#ent", "pos": [12, 13]}}
{"token": ["This", "response", "is", "signaled", "by", "the", "two", "peptide", "hormones", "glucose-dependent", "insulinotropic", "polypeptide", "GIP", ")", "(", "also", "known", "as", "gastric", "inhibitory", "polypeptide", "and", "C0061355#ent", "<e1>", "binding", "and", "activation", "of", "their", "C1333692#ent", "<e2>", "GPCRs", ")", "."], "h": {"id": "C0061355", "name": "C0061355#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1333692", "name": "C1333692#ent", "pos": [29, 30]}}
{"token": ["The", "C0751955#ent", "<e1>", "volume", "was", "measured", "from", "the", "C1421224#ent", "<e2>", "."], "h": {"id": "C0751955", "name": "C0751955#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1421224", "name": "C1421224#ent", "pos": [8, 9]}}
{"token": ["Six", "patients", "with", "C1337098#ent", "<e1>", "met", "the", "New", "York", "criteria", "C0574960#ent", "<e2>", "."], "h": {"id": "C1337098", "name": "C1337098#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0574960", "name": "C0574960#ent", "pos": [10, 11]}}
{"token": ["Whereas", "high", "baseline", "expression", "of", "CLCA1", ",", "periostin", ",", "and", "C1418253#ent", "<e1>", "was", "associated", "with", "good", "clinical", "response", "corticosteroids", ",", "high", "expression", "of", "C1414627#ent", "<e2>", "was", "associated", "with", "poor", "response"], "h": {"id": "C1418253", "name": "C1418253#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414627", "name": "C1414627#ent", "pos": [23, 24]}}
{"token": ["The", "hydrolysate", "of", "porcine", "skin", "collagen", "C0039815#ent", "<e1>", "or", "bacterial", "collagenase", "inhibited", "C3896655#ent", "<e2>", "but", "did", "not", "inhibit", "the", "activity", "of", "thrombin", "."], "h": {"id": "C0039815", "name": "C0039815#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3896655", "name": "C3896655#ent", "pos": [12, 13]}}
{"token": ["The", "cottontail", "rabbit", "papillomavirus", "CRPV", ")", "a", "and", "b", "subtypes", "display", "a", "conserved", "E8", "open", "reading", "frame", "a", "50-amino-acid", "hydrophobic", "protein", "with", "structural", "similarities", "to", "the", "C0021699#ent", "<e1>", "genital", "human", "C1419141#ent", "<e2>", "(", "HPVs", ")", "."], "h": {"id": "C0021699", "name": "C0021699#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1419141", "name": "C1419141#ent", "pos": [30, 31]}}
{"token": ["These", "malignancies", "result", "from", "the", "disorganization", "of", "a", "C1333200#ent", "<e1>", "network", "in", "which", "the", "C2984547#ent", "<e2>", "."], "h": {"id": "C1333200", "name": "C1333200#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2984547", "name": "C2984547#ent", "pos": [14, 15]}}
{"token": ["C0008145#ent", "<e1>", "pretreatment", "with", "either", "wheat", "germ", "agglutinin", "membrane", "proteins", "C0026705#ent", "<e2>", ")", "from", "V.", "alginolyticus", "caused", "a", "reduction", "in", "attachment", ",", "of", "50", "-", "57", "%", "and", "53", "-", "70", "%", ",", "respectively", "."], "h": {"id": "C0008145", "name": "C0008145#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026705", "name": "C0026705#ent", "pos": [10, 11]}}
{"token": ["C4284184#ent", "<e1>", "expected", "to", "be", "C0050397#ent", "<e2>", "rather", "than", "AUG", "."], "h": {"id": "C4284184", "name": "C4284184#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0050397", "name": "C0050397#ent", "pos": [5, 6]}}
{"token": ["These", "data", "are", "consistent", "with", "previous", "observations", "in", "MPTP", "monkeys", "developing", "dyskinesias", "following", "C1539521#ent", "<e1>", "or", "dopamine", "C0243192#ent", "<e2>", "treatment", "."], "h": {"id": "C1539521", "name": "C1539521#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [17, 18]}}
{"token": ["Two", "excision-deficient", "mutants", "of", "Neurospora", "crassa", "normal", "levels", "of", "two", "C3540772#ent", "<e1>", ",", "a", "single-strand-specific", "exonuclease", "and", "a", "C2350176#ent", "<e2>", "which", "attack", "UV-irradiated", "DNA", "."], "h": {"id": "C3540772", "name": "C3540772#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C2350176", "name": "C2350176#ent", "pos": [18, 19]}}
{"token": ["This", "article", "describes", "the", "clinical", "and", "pathologic", "features", "two", "spontaneously", "occurring", "murine", "models", "of", "inherited", "C3149841#ent", "<e1>", "to", "independent", "C0002085#ent", "<e2>", "mutations", "on", "mouse", "chromosome", "8"], "h": {"id": "C3149841", "name": "C3149841#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [19, 20]}}
{"token": ["We", "describe", "herein", "three", "cases", "of", "unusual", "presentation", ":", "an", "C0038833#ent", "<e1>", "an", "acute", "cholecystitis", "and", "an", "C0007177#ent", "<e2>"], "h": {"id": "C0038833", "name": "C0038833#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007177", "name": "C0007177#ent", "pos": [17, 18]}}
{"token": ["The", "effect", "of", "intramuscular", "injections", "of", "the", "C0006400#ent", "<e1>", "the", "isometric", "contractile", "properties", "of", "rat", "extensor", "digitorum", "longus", "C3815598#ent", "<e2>", ")", "muscle", "was", "studied", "."], "h": {"id": "C0006400", "name": "C0006400#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3815598", "name": "C3815598#ent", "pos": [18, 19]}}
{"token": ["Mutations", "in", "genes", "encoding", "proteins", "essential", "for", "the", "prenylation", "reaction", "C1413394#ent", "<e1>", "Rab", "geranylgeranyl", "transferase", "lead", "to", "genetic", "diseases", "Choroideremia", "and", "C0079504#ent", "<e2>"], "h": {"id": "C1413394", "name": "C1413394#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0079504", "name": "C0079504#ent", "pos": [21, 22]}}
{"token": ["24-Oxa-D3", "is", "thus", "a", "new", "metabolic", "weak", "antagonist", "of", "C3265062#ent", "<e1>", "but", "adding", "a", "hydroxyl", "group", "C-1", "creates", "a", "weak", "C0243192#ent", "<e2>", "."], "h": {"id": "C3265062", "name": "C3265062#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [20, 21]}}
{"token": ["Disease-specific", "oligosaccharides", "identified", "for", "several", "oligosaccharidurias", ",", "including", "GM1", "gangliosidosis", "GM2", "gangliosidosis", "C0342853#ent", "<e1>", "sialidase/neuraminidase", "deficiency", "galactosialidosis", ",", "I-cell", "disease", "fucosidosis", ",", "Pompe", "and", "C0017205#ent", "<e2>", "and", "alpha-mannosidosis", "."], "h": {"id": "C0342853", "name": "C0342853#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017205", "name": "C0017205#ent", "pos": [24, 25]}}
{"token": ["Both", "ICI-182780", "and", "C0618111#ent", "<e1>", "inhibited", "the", "ERE-dependent", "agonist", "activity", "of", "17beta-estradiol", "and", "C0139560#ent", "<e2>", "in", "osteoblastic", "cells"], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0139560", "name": "C0139560#ent", "pos": [13, 14]}}
{"token": ["These", "promising", "results", "support", "the", "continued", "development", "of", "mutant", "E6", "and", "E7", "C1336933#ent", "<e1>", "as", "safe", "and", "effective", "C1332838#ent", "<e2>", "for", "clinical", "evaluation", "HPV-associated", "disease", "."], "h": {"id": "C1336933", "name": "C1336933#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332838", "name": "C1332838#ent", "pos": [18, 19]}}
{"token": ["The", "X", ":", "A", "signal", "is", "then", "equivalent", "between", "C1704669#ent", "<e1>", "and", "XX", "animals", ",", "causing", "sexual", "differentiation", "be", "controlled", "by", "C1417679#ent", "<e2>", "downstream", "of", "xol-1", "in", "the", "sex-determination", "pathway", "."], "h": {"id": "C1704669", "name": "C1704669#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [21, 22]}}
{"token": ["The", "human", "gene", "found", "to", "contain", "five", "exons", "encoding", "a", "protein", "composed", "of", "402", "C3539946#ent", "<e1>", "is", "98.8", "%", "identical", "to", "mouse", "C1422491#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1422491", "name": "C1422491#ent", "pos": [22, 23]}}
{"token": ["ALG11", "suppressed", "the", "gmd3", "mutation", ",", "indicating", "that", "gmd3(+", ")", "gene", "is", "a", "functional", "C1334043#ent", "<e1>", "of", "the", "C1876205#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1876205", "name": "C1876205#ent", "pos": [18, 19]}}
{"token": ["Thirty-three", "patients", "with", "C0016034#ent", "<e1>", "laparoscopic", "nephrectomy", "23", "by", "the", "C3541334#ent", "<e2>", "and", "10", "by", "the", "RP", "approach", "."], "h": {"id": "C0016034", "name": "C0016034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541334", "name": "C3541334#ent", "pos": [10, 11]}}
{"token": ["Smooth", "muscle", "cells", "C3888088#ent", "<e1>", ")", "are", "a", "major", "source", "of", "C1705527#ent", "<e2>", "within", "the", "vascular", "wall", "and", "C1705527#ent", "<e2>", "was", "implicated", "in", "C3888088#ent", "<e1>", "migration", ",", "proliferation", ",", "and", "apoptosis", "."], "h": {"id": "C1705527", "name": "C1705527#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3888088", "name": "C3888088#ent", "pos": [3, 4]}}
{"token": ["Therapeutic", "modalities", "antihypertensive", "drug", "therapy", "81", "patients", ",", "C0003448#ent", "<e1>", "8", "patients", ",", "steroids", "in", "16", "patients", "and", "C1161438#ent", "<e2>", "in", "one", "patient", "."], "h": {"id": "C0003448", "name": "C0003448#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [18, 19]}}
{"token": ["Activation", "of", "the", "human", "complement", "system", "plasma", "proteins", "response", "to", "infection", "or", "injury", "produces", "a", "4-helix", "bundle", "glycoprotein", "(", "74", "C3539946#ent", "<e1>", "known", "as", "C1367710#ent", "<e2>", "."], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1367710", "name": "C1367710#ent", "pos": [24, 25]}}
{"token": ["Furthermore", ",", "treatment", "of", "3T3-L1", "fibroblasts", "with", "C0036075#ent", "<e1>", ",", "a", "potent", "stimulator", "of", "p38", ",", "produces", "C1540187#ent", "<e2>", "changes", "consistent", "with", "observed", "with", "induction", "of", "MKK6(Glu", ")", "."], "h": {"id": "C0036075", "name": "C0036075#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1540187", "name": "C1540187#ent", "pos": [17, 18]}}
{"token": ["Finally", ",", "we", "identified", "a", "linear", "epitope", "amino", "acids", "residues", "-", "22", "of", "C1414926#ent", "<e1>", "that", "was", "recognized", "solely", "by", "autoantibodies", "from", "patients", "with", "C4255078#ent", "<e2>", "but", "not", "by", "serum", "from", "type", "1", "diabetes", "patients", "."], "h": {"id": "C1414926", "name": "C1414926#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4255078", "name": "C4255078#ent", "pos": [24, 25]}}
{"token": ["The", "definitive", "diagnosis", "of", "C1384588#ent", "<e1>", "biopsy", "or", "morphologically", "proven", "C0027059#ent", "<e2>", "evidence", "of", "bacterial", "invasion", "positive", "tissue", "cultures", "."], "h": {"id": "C1384588", "name": "C1384588#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0027059", "name": "C0027059#ent", "pos": [10, 11]}}
{"token": ["C1418457#ent", "<e1>", "colocalized", "with", "C1424492#ent", "<e2>", "in", "up", "to", "77", "%", "of", "varicosities", "(", "17", "+", "/-", "21", "%", ",", "n", "=", "21", "neurons", ")", "."], "h": {"id": "C1418457", "name": "C1418457#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424492", "name": "C1424492#ent", "pos": [4, 5]}}
{"token": ["Cepacidine", "A", "a", "novel", "C0061642#ent", "<e1>", "with", "a", "potent", "C0003308#ent", "<e2>", "which", "is", "produced", "by", "Pseudomonas", "cepacia", "AF", "."], "h": {"id": "C0061642", "name": "C0061642#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [9, 10]}}
{"token": ["Rat", "neonatal", "cardiac", "myocytes", "exposed", "to", "H2O2", ",", "and", "changes", "in", "c-fos", "and", "c-jun", "mRNAs", ",", "immunoreactive", "c-Fos", "and", "c-Jun", "proteins", "components", "of", "C0162508#ent", "<e1>", ")", ",", "and", "immunoreactive", "C1423613#ent", "<e2>", "NF-kappa", "B", "determined", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1423613", "name": "C1423613#ent", "pos": [29, 30]}}
{"token": ["A", "five", "week", "old", "male", "infant", "is", "treated", "under", "suspicion", "of", "C0043168#ent", "<e1>", "of", "pertussis", "like", "cough", ",", "C0521800#ent", "<e2>", ",", "and", "attacks", "of", "reflex", "apnea"], "h": {"id": "C0043168", "name": "C0043168#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0521800", "name": "C0521800#ent", "pos": [18, 19]}}
{"token": ["pRB-deficient", "MEFs", "exhibit", "an", "increased", "expression", "of", "the", "Forkhead", "transcription", "factor", "C1414669#ent", "<e1>", "and", "its", "target", "C1418910#ent", "<e2>", "resulting", "in", "increased", "cAMP", "sensitivity", "."], "h": {"id": "C1414669", "name": "C1414669#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1418910", "name": "C1418910#ent", "pos": [16, 17]}}
{"token": ["2B4-L", "is", "a", "member", "of", "the", "CD2", "subgroup", "the", "C1334163#ent", "<e1>", "which", "includes", "C1413226#ent", "<e2>", ",", "LFA-3", ",", "CD84", ",", "Ly9", "and", "SLAM", "."], "h": {"id": "C1334163", "name": "C1334163#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1413226", "name": "C1413226#ent", "pos": [13, 14]}}
{"token": ["C0299046#ent", "<e1>", "is", "a", "novel", "C0016411#ent", "<e2>", "thymidylate", "synthase", "TS", ")", "."], "h": {"id": "C0299046", "name": "C0299046#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0016411", "name": "C0016411#ent", "pos": [5, 6]}}
{"token": ["Decreased", "salivary", "flow", "achieved", "by", "oral", "administration", "either", "C0087119#ent", "<e1>", ",", "Benadryl", "or", "C0004259#ent", "<e2>", "."], "h": {"id": "C0087119", "name": "C0087119#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0004259", "name": "C0004259#ent", "pos": [13, 14]}}
{"token": ["Sandwich-complex", "formation", "of", "C0030956#ent", "<e1>", "two", "DNA", "fragments", "two", "symmetrical", "C1511573#ent", "<e2>", "binding", "sites", "(", "5'-ATGACGTCAT-3", "'", ")", "at", "a", "distance", "of", "21", "bp", "suggests", "antiparallel", "aggregation", "the", "Lac", "leucine", "heptad", "repeats", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1511573", "name": "C1511573#ent", "pos": [10, 11]}}
{"token": ["Looking", "for", "HFE", "mutations", "help", "to", "separate", "C1853733#ent", "<e1>", "other", "conditions", "mainly", "C0037061#ent", "<e2>", "metabolic", "disorders", "."], "h": {"id": "C1853733", "name": "C1853733#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0037061", "name": "C0037061#ent", "pos": [12, 13]}}
{"token": ["Clinical", "drug-drug", "interaction", "studies", "well", "as", "in", "vitro", "drug", "metabolism", "studies", "that", "CYP1A2", ",", "in", "addition", "to", "C3887685#ent", "<e1>", ",", "is", "involved", "in", "the", "metabolism", "of", "C0543459#ent", "<e2>", "in", "man", "."], "h": {"id": "C3887685", "name": "C3887685#ent", "pos": [17, 18]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0543459", "name": "C0543459#ent", "pos": [26, 27]}}
{"token": ["In", "contrast", ",", "the", "drug", "failed", "to", "affect", "endogenous", ",", "C1538577#ent", "<e1>", "induced", "in", "nuclei", "of", "S49-leukemia", "cells", "by", "C0011522#ent", "<e2>", "."], "h": {"id": "C1538577", "name": "C1538577#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011522", "name": "C0011522#ent", "pos": [19, 20]}}
{"token": ["The", "effect", "of", "C0001475#ent", "<e1>", "ATPase", ")", "on", "relaxation", "induced", "by", "C0282210#ent", "<e2>", ",", "prostaglandin", "E2", "sodium", "nitroprusside", "and", "forskolin", ",", "a", "specific", "stimulant", "of", "adenylate", "cyclase", "was", "investigated", "in", "canine", "tracheal", "smooth", "muscle", "strips", "."], "h": {"id": "C0001475", "name": "C0001475#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "showed", "that", "levels", "of", "C1512213#ent", "<e1>", "GPT", ")", ",", "as", "well", "as", "glutamate-oxalate-transaminase", "(", "C0004002#ent", "<e2>", ")", ",", "were", "increased", "by", "the", "administration", "of", "CCl(4", ")", "."], "h": {"id": "C1512213", "name": "C1512213#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0004002", "name": "C0004002#ent", "pos": [16, 17]}}
{"token": ["Effects", "of", "thiophenecarboxamide", "hydrochloride", "(", "C0104221#ent", "<e1>", ",", "S-596", ")", "on", "hemodynamic", "and", "C0001637#ent", "<e2>", "induced", "renin", "release", "and", "renal", "vasoconstriction", "investigated", "in", "pentobarbital", "anesthetized", "dogs", "."], "h": {"id": "C0104221", "name": "C0104221#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001637", "name": "C0001637#ent", "pos": [13, 14]}}
{"token": ["The", "outcomes", "of", "20", "C0303755#ent", "<e1>", "coal", "workers", "pneumoconiosis", "and", "C0041327#ent", "<e2>", "treated", "with", "chemotherapeutic", "regimens", "determined", "by", "a", "retrospective", "review"], "h": {"id": "C0303755", "name": "C0303755#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041327", "name": "C0041327#ent", "pos": [10, 11]}}
{"token": ["Additional", "questions", "concerning", "the", "reduction", "of", "proteinuria", "and", "its", "relationship", "to", "end-stage", "renal", "disease", "C0035078#ent", "<e1>", ")", "as", "well", "as", "C2242703#ent", "<e2>", "the", "safety", "and", "tolerability", "of", "losartan", "remain", "to", "be", "addressed", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2242703", "name": "C2242703#ent", "pos": [20, 21]}}
{"token": ["The", "occurrence", "of", "MRSA", "in", "C1704461#ent", "<e1>", "and", "the", "relative", "roles", "of", "C0015674#ent", "<e2>", "and", "C1704461#ent", "<e1>", "in", "MRSA", "transmission", "have", "not", "been", "well", "characterized", "."], "h": {"id": "C1704461", "name": "C1704461#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0015674", "name": "C0015674#ent", "pos": [12, 13]}}
{"token": ["In", "the", "following", "we", "describe", "a", "case", "of", "C0004698#ent", "<e1>", "which", "exhibited", ",", "a", "few", "years", "after", "acute", "infection", "arterial", "hypertension", "C0022667#ent", "<e2>"], "h": {"id": "C0004698", "name": "C0004698#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022667", "name": "C0022667#ent", "pos": [21, 22]}}
{"token": ["We", "report", "here", "the", "effects", "of", "antagonists", ",", "C0280858#ent", "<e1>", ",", "diltiazem", "and", "nifedipine", ";", "the", "C0243192#ent", "<e2>", ",", "bay", "K8644", "the", "calcium", "ionophore", "A23187", "on", "the", "release", "of", "endogenous", "glutamate", "from", "rat", "cerebellar", "slices"], "h": {"id": "C0280858", "name": "C0280858#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [16, 17]}}
{"token": ["C1412498#ent", "<e1>", "is", "expressed", "in", "the", "intestinal", "epithelia", ",", "C0036091#ent", "<e2>", "pancreas", ",", "and", "liver", "."], "h": {"id": "C1412498", "name": "C1412498#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [9, 10]}}
{"token": ["We", "examined", "the", "acute", "postprandial", "effects", "of", "meals", "containing", "unsaturated", "fatty", "acids", "flow-mediated", "dilation", "C3810599#ent", "<e1>", ")", "of", "the", "brachial", "artery", "C0017860#ent", "<e2>", "in", "individuals", "with", "type", "2", "diabetes"], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [21, 22]}}
{"token": ["Only", "those", "rho-", "mitochondrial", "C0017428#ent", "<e1>", "lacking", "the", "CT", "recognition", "sequence", "unaffected", "by", "the", "C1413931#ent", "<e2>", "allele", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1413931", "name": "C1413931#ent", "pos": [14, 15]}}
{"token": ["Hence", ",", "it", "appears", "that", "C3711837#ent", "<e1>", "not", "an", "C0084378#ent", "<e2>"], "h": {"id": "C3711837", "name": "C3711837#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0084378", "name": "C0084378#ent", "pos": [9, 10]}}
{"token": ["Age-related", "modulation", "in", "vasodilating", "actions", "induced", "by", "C2929388#ent", "<e1>", "C0772125#ent", "<e2>", ")", "and", "bilobalide", ",", "a", "main", "constituent", "of", "C0772125#ent", "<e2>", ",", "were", "examined", "using", "rat", "aorta", "ring", "strips", "."], "h": {"id": "C2929388", "name": "C2929388#ent", "pos": [7, 8]}, "relation": "has_constitutional_part", "t": {"id": "C0772125", "name": "C0772125#ent", "pos": [9, 10]}}
{"token": ["Biochemical", "experiments", "the", "presence", "of", "AsnRS", "and", "GlnRS", ",", "as", "well", "as", "C1825021#ent", "<e1>", "GluRS", ")", ",", "a", "discriminating", "and", "a", "nondiscriminating", "aspartyl-tRNA", "synthetase", "C1839730#ent", "<e2>", ")", "."], "h": {"id": "C1825021", "name": "C1825021#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1839730", "name": "C1839730#ent", "pos": [24, 25]}}
{"token": ["C0010346#ent", "<e1>", "CD", ")", "and", "ulcerative", "colitis", "UC", ")", "are", "associated", "with", "C0006109#ent", "<e2>", "continuous", "tissue", "repair"], "h": {"id": "C0010346", "name": "C0010346#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006109", "name": "C0006109#ent", "pos": [12, 13]}}
{"token": ["C0245109#ent", "<e1>", "is", "used", "in", "the", "treatment", "of", "C0003873#ent", "<e2>", "but", "its", "therapeutic", "potential", "has", "not", "been", "proved", "in", "patients", "with", "SLE", "."], "h": {"id": "C0245109", "name": "C0245109#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [8, 9]}}
{"token": ["However", ",", "in", "the", "presence", "of", "C0025842#ent", "<e1>", "or", "following", "destruction", "of", "descending", "spinal", "serotonergic", "projections", "by", "C0000543#ent", "<e2>", ",", "central", "serotonin", "produces", "hyperlocomotion", "."], "h": {"id": "C0025842", "name": "C0025842#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0000543", "name": "C0000543#ent", "pos": [17, 18]}}
{"token": ["In", "axial", "muscle", "fibers", "H.", "contortus", ",", "C0282372#ent", "<e1>", "did", "not", "block", "the", "depolarizing", "actions", "of", "pyrantel", ",", "C0023556#ent", "<e2>", ",", "or", "nicotine", "."], "h": {"id": "C0282372", "name": "C0282372#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023556", "name": "C0023556#ent", "pos": [18, 19]}}
{"token": ["H7", ",", "a", "C1517755#ent", "<e1>", "protein", "kinase", "C", "completely", "blocked", "C0162508#ent", "<e2>", "expression", "in", "20(S)-camptothecin-treated", "cells", ",", "while", "another", "protein", "kinase", "inhibitor", "HA1004", ",", "had", "no", "detectable", "effect", "."], "h": {"id": "C1517755", "name": "C1517755#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [10, 11]}}
{"token": ["The", "C1415793#ent", "<e1>", "selectively", "augmented", "the", "release", "of", "C0124604#ent", "<e2>", ";", "also", ",", "the", "glycosylphosphatidylinositol-PLC", "inhibitor", "zinc", ",", "blocked", "this", "increase", "in", "release", "."], "h": {"id": "C1415793", "name": "C1415793#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0124604", "name": "C0124604#ent", "pos": [8, 9]}}
{"token": ["While", "the", "gamma", "subunits", "C1705766#ent", "<e1>", ",", "Gi", ",", "and", "Go", "have", "identical", "electrophoretic", "mobility", "C0272170#ent", "<e2>", "gels", ",", "they", "differ", "significantly", "in", "this", "respect", "from", "the", "gamma", "subunit", "transducin", "."], "h": {"id": "C1705766", "name": "C1705766#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0272170", "name": "C0272170#ent", "pos": [15, 16]}}
{"token": ["Simultaneously", ",", "C0006938#ent", "<e1>", "lead", "to", "reduction", "in", "C0026848#ent", "<e2>", "lactate", "and", "pyruvate", "."], "h": {"id": "C0006938", "name": "C0006938#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [8, 9]}}
{"token": ["C0010621#ent", "<e1>", "the", "lowest", "doses", "no", "inhibitory", "effect", "on", "thymus", "or", "C1705087#ent", "<e2>", "formation", "but", "also", "did", "not", "affect", "spermatogenesis", "in", "albino", "guinea", "pigs", "."], "h": {"id": "C0010621", "name": "C0010621#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705087", "name": "C1705087#ent", "pos": [11, 12]}}
{"token": ["Further", ",", "PON1", "promoter", "activity", "enhanced", "by", "C1517132#ent", "<e1>", "FTI", ")", ",", "but", "not", "by", "geranylgeranyl", "transferase", "inhibitor", "C1514546#ent", "<e2>", ")", "."], "h": {"id": "C1517132", "name": "C1517132#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1514546", "name": "C1514546#ent", "pos": [18, 19]}}
{"token": ["Myeloperoxidase", "is", "a", "member", "of", "a", "family", "of", "C1512488#ent", "<e1>", "mammalian", "peroxidases", "that", "includes", "thyroid", "peroxidase", "eosinophil", "peroxidase", "C1416903#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1416903", "name": "C1416903#ent", "pos": [18, 19]}}
{"token": ["The", "results", "are", "discussed", "with", "respect", "to", "known", "kinetic", "data", "of", "C1512488#ent", "<e1>", "mammalian", "peroxidases", "and", "to", "the", "physiological", "role", "of", "C1416903#ent", "<e2>", "in", "antimicrobial", "defense"], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1416903", "name": "C1416903#ent", "pos": [21, 22]}}
{"token": ["Warren", "has", "shown", "that", "DTT", "and", "mercaptoethanol", "produce", "significantly", "greater", "C1872855#ent", "<e1>", "activities", "than", "cysteine", ",", "dithioerythritol", "(", "C1539218#ent", "<e2>", ")", ",", "glutathione", ",", "or", "mercaptoacetate", "(", "3", ")", "."], "h": {"id": "C1872855", "name": "C1872855#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539218", "name": "C1539218#ent", "pos": [18, 19]}}
{"token": ["Although", "C1512488#ent", "<e1>", "to", "murine", "C1420708#ent", "<e2>", "in", "the", "coding", "region", "the", "TfR2", "transcript", "does", "not", "contain", "the", "iron-responsive", "elements", "in", "the", "3", "'", "untranslated", "sequence", "of", "C1420708#ent", "<e2>", "mRNA", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420708", "name": "C1420708#ent", "pos": [5, 6]}}
{"token": ["The", "C0003191#ent", "<e1>", "no", "effect", "isolated", "neutrophil", "membrane", "protease", ",", "a", "C0055673#ent", "<e2>", "has", "been", "implicated", "in", "the", "activation", "of", "NAD(P)H", "oxidase"], "h": {"id": "C0003191", "name": "C0003191#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [11, 12]}}
{"token": ["Here", ",", "we", "provide", "evidence", "that", "physical", "activity", "against", "C0948008#ent", "<e1>", "mechanisms", "related", "to", "the", "upregulation", "of", "endothelial", "nitric", "oxide", "synthase", "C1328053#ent", "<e2>", ")", "in", "the", "vasculature", "."], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1328053", "name": "C1328053#ent", "pos": [21, 22]}}
{"token": ["Culture", "of", "H4IIEC3", "cells", "at", "low", "density", "on", "C0009325#ent", "<e1>", "promoted", "a", "flattened", "morphology", "and", "low", "C1418372#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418372", "name": "C1418372#ent", "pos": [16, 17]}}
{"token": ["At", "high", "density", "cells", "assumed", "a", "cuboidal", "shape", "on", "both", "plastic", "and", "C0009325#ent", "<e1>", "and", "expressed", "high", "C1418372#ent", "<e2>", "mRNA", "levels", "."], "h": {"id": "C0009325", "name": "C0009325#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418372", "name": "C1418372#ent", "pos": [17, 18]}}
{"token": ["We", "have", "investigated", "the", "role", "of", "cell-cell", "cooperation", "the", "activation", "of", "C0526871#ent", "<e1>", "in", "the", "liver", ",", "using", "pure", "cultures", "co-cultures", "of", "C0669372#ent", "<e2>", "and", "hepatic", "stellate", "cells", "HSCs", ")", "."], "h": {"id": "C0526871", "name": "C0526871#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [22, 23]}}
{"token": ["Values", "48", "h", "after", "the", "last", "C1412446#ent", "<e1>", "were", "similar", "to", "those", "obtained", "before", "the", "second", "C1412446#ent", "<e1>", ",", "suggesting", "that", "repeated", "infusions", "of", "C0020352#ent", "<e1>", "had", "no", "detrimental", "effect", "on", "monocyte", "function"], "h": {"id": "C1412446", "name": "C1412446#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020352", "name": "C0020352#ent", "pos": [24, 25]}}
{"token": ["Abundance", "of", "PDH1", "and", "CgCDR1", "mRNA", "in", "C.", "glabrata", "increased", "by", "C0073193#ent", "<e1>", "cycloheximide", "and", "oligomycin", ",", "properties", "in", "common", "with", "C1705132#ent", "<e2>", "."], "h": {"id": "C0073193", "name": "C0073193#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705132", "name": "C1705132#ent", "pos": [21, 22]}}
{"token": ["C0752304#ent", "<e1>", "the", "immediate", "cause", "of", "death", "in", "all", "delayed", "C2697643#ent", "<e2>", "cases", "."], "h": {"id": "C0752304", "name": "C0752304#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697643", "name": "C2697643#ent", "pos": [10, 11]}}
{"token": ["Microarray", "analysis", "angiogenesis-related", "genes", "the", "enhanced", "expression", "of", "a", "number", "of", "C0017337#ent", "<e1>", ",", "among", "these", "was", "C4277634#ent", "<e2>", "(", "a", "disintegrin", "and", "metalloproteinase", "with", "thrombospondin", "motif-1", ",", "a", "secreted", "VEGF", "inhibitor", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4277634", "name": "C4277634#ent", "pos": [17, 18]}}
{"token": ["The", "deduced", "amino", "acid", "sequence", "C3811249#ent", "<e1>", "shows", "similarity", "to", "S-adenosyl-L-methionine", ":", "C0672164#ent", "<e2>", "Clarkia", "breweri", "is", "expressed", "mostly", "in", "petals", "."], "h": {"id": "C3811249", "name": "C3811249#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0672164", "name": "C0672164#ent", "pos": [12, 13]}}
{"token": ["The", "potential", "angiotensin", "II-forming", "enzymes", "are", "angiotensin-converting", "enzyme", "ACE", ")", "and", "chymostatin-sensitive", "angiotensin", "II-generating", "enzyme", "CAGE", ")", "which", "is", "highly", "C1334043#ent", "<e1>", "to", "or", "could", "be", "identical", "to", "the", "C4085186#ent", "<e2>"], "h": {"id": "C1334043", "name": "C1334043#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C4085186", "name": "C4085186#ent", "pos": [29, 30]}}
{"token": ["An", "in-gel", "kinase", "assay", "demonstrated", "that", "C3811163#ent", "<e1>", "is", "a", "major", "C0380051#ent", "<e2>", "can", "phosphorylate", "small", "heat", "shock", "protein", "suggesting", "a", "potential", "role", "for", "C3811163#ent", "<e1>", "in", "mediating", "stress-induced", "HSP27", "phosphorylation", "in", "vivo"], "h": {"id": "C3811163", "name": "C3811163#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [11, 12]}}
{"token": ["C0406563#ent", "<e1>", "always", "been", "associated", "with", "congenital", "malformations", ",", "C0282102#ent", "<e2>", "Bazex", "'s", "syndrome", "and", "keratosis", "palmaris", "plantaris", "dissipata", "."], "h": {"id": "C0406563", "name": "C0406563#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0282102", "name": "C0282102#ent", "pos": [9, 10]}}
{"token": ["There", "is", "no", "preferential", "in", "vitro", "inhibition", "of", "induced", "versus", "C1537381#ent", "<e1>", "activities", "by", "either", "C0053490#ent", "<e2>", "or", "metyrapone", "."], "h": {"id": "C1537381", "name": "C1537381#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0053490", "name": "C0053490#ent", "pos": [15, 16]}}
{"token": ["Mice", "lacking", "C1970208#ent", "<e1>", "exhibit", "reduced", "locomotor", "activity", "lower", "expression", "of", "C1417815#ent", "<e2>", "and", "Agrp", "."], "h": {"id": "C1970208", "name": "C1970208#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417815", "name": "C1417815#ent", "pos": [11, 12]}}
{"token": ["NF-kappaB", "is", "an", "inducible", "C3275238#ent", "<e1>", "the", "expression", "of", "many", "C1417679#ent", "<e2>", "."], "h": {"id": "C3275238", "name": "C3275238#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [10, 11]}}
{"token": ["Heterozygous", "microdeletion", "chromosome", "7q11.23", "this", "patient", "is", "typical", "for", "WS", ",", "the", "delction", "including", "C0013765#ent", "<e1>", "(", "ELN", ")", "and", "C1334342#ent", "<e2>"], "h": {"id": "C0013765", "name": "C0013765#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334342", "name": "C1334342#ent", "pos": [20, 21]}}
{"token": ["Melanin", "biosynthesis", "regulated", "by", "a", "number", "of", "melanocyte-specific", "proteins", "including", "tyrosinase", ",", "C0114832#ent", "<e1>", "DCT", ")", ",", "and", "tyrosinase-related", "protein-1", "TRP-1", ",", "C1336694#ent", "<e2>", ")", "."], "h": {"id": "C0114832", "name": "C0114832#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1336694", "name": "C1336694#ent", "pos": [22, 23]}}
{"token": ["Pretreatment", "of", "OK", "cells", "with", "the", "nonreceptor", "tyrosine", "kinase", "inhibitors", "genistein", "and", "C0062566#ent", "<e1>", "A", "or", "with", "the", "C2936824#ent", "<e2>", "PI-3K", "inhibitors", "wortmannin", "and", "LY294002", "blocked", "the", "early", "and", "late", "peaks", "PTH-stimulated", "ERK", "activity", "."], "h": {"id": "C0062566", "name": "C0062566#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2936824", "name": "C2936824#ent", "pos": [18, 19]}}
{"token": ["In", "bilaterally", "castrated", "rats", ",", "immediate", "and", "delayed", "testosterone", "replacement", "the", "dependence", "of", "C4049874#ent", "<e1>", "expression", "on", "circulating", "C0002842#ent", "<e2>", "."], "h": {"id": "C4049874", "name": "C4049874#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002842", "name": "C0002842#ent", "pos": [18, 19]}}
{"token": ["The", "blood", "glucose-lowering", "hormone", "glucagon-like", "peptide-1", "C0061355#ent", "<e1>", ")", "stimulates", "cAMP", "production", ",", "promotes", "C1413043#ent", "<e2>", "+", "influx", ",", "and", "mobilizes", "an", "intracellular", "source", "of", "C1413043#ent", "<e2>", "+", "in", "pancreatic", "beta", "cells"], "h": {"id": "C0061355", "name": "C0061355#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [14, 15]}}
{"token": ["In", "disorders", "accompanied", "by", "parakeratosis", ",", "a", "sign", "of", "incomplete", "differentiation", "(", "psoriasis", ",", "C0033771#ent", "<e1>", "loricrin", "was", "not", "detected", ",", "whereas", "the", "tissue", "expressed", "C1414633#ent", "<e2>", "."], "h": {"id": "C0033771", "name": "C0033771#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414633", "name": "C1414633#ent", "pos": [25, 26]}}
{"token": ["C0146868#ent", "<e1>", "is", "no", "more", "efficacious", "than", "C0039286#ent", "<e2>", "and", "has", "more", "toxicity", "."], "h": {"id": "C0146868", "name": "C0146868#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [7, 8]}}
{"token": ["Mass", "newborn", "was", "started", "in", "October", "1977", "throughout", "Japan", "in", "order", "to", "detect", "five", "inborn", "errors", "metabolism", "including", "phenylketonuria", ",", "maple", "syrup", "C0012634#ent", "<e1>", "homocystinuria", ",", "histidinemia", ",", "and", "C0016952#ent", "<e2>", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0016952", "name": "C0016952#ent", "pos": [29, 30]}}
{"token": ["Southern", "analysis", "that", "the", "C0079429#ent", "<e1>", "that", "encodes", "C1420648#ent", "<e2>", "is", "conserved", "among", "clinical", "isolates", "the", "Haemophilus", "cryptic", "genospecies", "is", "absent", "from", "the", "closely", "related", "species", "Haemophilus", "influenzae"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1420648", "name": "C1420648#ent", "pos": [8, 9]}}
{"token": ["The", "results", "suggest", "that", "C0038366#ent", "<e1>", "and", "postherpetic", "allodynia", "is", "mediated", "by", "nitric", "oxide", "the", "dorsal", "horn", "that", "C0669372#ent", "<e2>", "and", "NOS1", "are", "responsible", "for", "C0038366#ent", "<e1>", "and", "postherpetic", "allodynia", ",", "respectively", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0038366", "name": "C0038366#ent", "pos": [4, 5]}}
{"token": ["Paradoxically", ",", "C0085859#ent", "<e1>", "patients", "suffer", "from", "C0006845#ent", "<e2>"], "h": {"id": "C0085859", "name": "C0085859#ent", "pos": [2, 3]}, "relation": "has_manifestation", "t": {"id": "C0006845", "name": "C0006845#ent", "pos": [7, 8]}}
{"token": ["Dazoxiben", "did", "not", "alleviate", "the", "C0014805#ent", "<e1>", "in", "patients", "with", "C0040028#ent", "<e2>", "complete", "inhibition", "of", "platelet", "malondialdehyde", "thromboxane", "B(2", ")", "synthesis", "and", "no", "inhibition", "of", "prostaglandin-E-like", "material", "."], "h": {"id": "C0014805", "name": "C0014805#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0040028", "name": "C0040028#ent", "pos": [10, 11]}}
{"token": ["C4289986#ent", "<e1>", "salt-wasting", "forms", "congenital", "adrenal", "hyperplasia", "and", "adrenal", "hypoplasia", "congenita", "cause", "C0020595#ent", "<e2>", "signs", "of", "which", "include", "hyponatremia", ",", "hyperkalemia", ",", "hypovolemia", ",", "elevated", "plasma", "renin", "activity", ",", "and", "sometimes", "shock", "and", "death", "."], "h": {"id": "C4289986", "name": "C4289986#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0020595", "name": "C0020595#ent", "pos": [12, 13]}}
{"token": ["The", "findings", "support", "that", "muscarinic-receptor-inhibitory", "actions", "in", "human", "bladder", "mainly", "contribute", "to", "the", "usefulness", "of", "C1099677#ent", "<e1>", "as", "a", "therapeutic", "drug", "C0878773#ent", "<e2>"], "h": {"id": "C1099677", "name": "C1099677#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0878773", "name": "C0878773#ent", "pos": [21, 22]}}
{"token": ["Thus", ",", "C1423062#ent", "<e1>", "share", "functions", "at", "many", "genomic", "targets", ",", "but", "C0812296#ent", "<e2>", "and", "Hst4", "have", "also", "evolved", "unique", "functions", "in", "gene", "regulation"], "h": {"id": "C1423062", "name": "C1423062#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0812296", "name": "C0812296#ent", "pos": [12, 13]}}
{"token": ["This", "group", "is", "unrelated", "to", "the", "classical", "trypsin", "C0752243#ent", "<e1>", "and", "includes", "dipeptidyl", "peptidase", "IV", "acylaminoacyl", "peptidase", "C0069437#ent", "<e2>", "in", "addition", "to", "the", "prototype", "prolyl", "oligopeptidase"], "h": {"id": "C0752243", "name": "C0752243#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0069437", "name": "C0069437#ent", "pos": [17, 18]}}
{"token": ["Run-on", "analysis", "demonstrated", "that", "C1335224#ent", "<e1>", "transcription", "was", "unaffected", "by", "C0919490#ent", "<e2>", ",", "suggesting", "that", "this", "enhancement", "mainly", "occurs", "at", "a", "post-transcriptional", "level"], "h": {"id": "C1335224", "name": "C1335224#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919490", "name": "C0919490#ent", "pos": [10, 11]}}
{"token": ["Three", "serological", "tests", "the", "diagnosis", "of", "C0026918#ent", "<e1>", "evaluated", "on", "29", "possums", "(", "Trichosurus", "vulpecula", "with", "C0041296#ent", "<e2>", "and", "on", "100", "possums", "from", "a", "tuberculosis-free", "area", "."], "h": {"id": "C0026918", "name": "C0026918#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [16, 17]}}
{"token": ["The", "clinical", "features", "of", "this", "atypical", "C0026918#ent", "<e1>", "are", "similar", "to", "C0041296#ent", "<e2>", "."], "h": {"id": "C0026918", "name": "C0026918#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0041296", "name": "C0041296#ent", "pos": [11, 12]}}
{"token": ["The", "obtained", "results", "have", "shown", "an", "overall", "decrease", "of", "liver", "microsomal", "cytochrome", "P450", "cytochrome", "b5", "C4078840#ent", "<e1>", "NADH-cytochrome", "b5", "reductase", "and", "aniline", "hydroxylase", "a", "subsequent", "decrease", "of", "phase", "II", "C3540790#ent", "<e2>", ",", "glutathione-S-transferase", "and", "UDP-glucuronyl", "transferase", "cancer-bearing", "animals", "."], "h": {"id": "C4078840", "name": "C4078840#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [29, 30]}}
{"token": ["Adult", "Refsum's", "disease", "ARD", ")", "is", "characterised", "by", "the", "presence", "of", "C0220701#ent", "<e1>", "ataxia", ",", "deafness", ",", "C0151313#ent", "<e2>", "and", "bony", "changes"], "h": {"id": "C0220701", "name": "C0220701#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0151313", "name": "C0151313#ent", "pos": [17, 18]}}
{"token": ["Therefore", ",", "C0038317#ent", "<e1>", "treatment", "may", "have", "a", "beneficial", "effect", "in", "C1412502#ent", "<e2>", "patients", "with", "bronchial", "hyperresponsiveness", "BHR", ")", "."], "h": {"id": "C0038317", "name": "C0038317#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1412502", "name": "C1412502#ent", "pos": [11, 12]}}
{"token": ["C0000737#ent", "<e1>", "a", "common", "presenting", "symptom", "in", "adults", "with", "sickle", "cell", "disease", "C0002895#ent", "<e2>", ")", "."], "h": {"id": "C0000737", "name": "C0000737#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [12, 13]}}
{"token": ["C0014130#ent", "<e1>", "such", "as", "thyroid", "dysfunction", "C0011849#ent", "<e2>", ",", "may", "be", "comorbidities", "in", "patients", "with", "epilepsy", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [6, 7]}}
{"token": ["We", "found", "that", "CT", "responses", "to", "C1412125#ent", "<e1>", "and", "HCl", "were", "increased", "by", "CCK-8", "and", "decreased", "by", "C1705783#ent", "<e2>", "."], "h": {"id": "C1412125", "name": "C1412125#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705783", "name": "C1705783#ent", "pos": [17, 18]}}
{"token": ["In", "addition", ",", "recent", "evidence", "has", "demonstrated", "that", "mutations", "in", "Nod1", "and", "Nod2", "are", "associated", "with", "number", "of", "human", "C1290884#ent", "<e1>", "including", "Crohn's", "disease", "Blau", "syndrome", "early-onset", "sarcoidosis", ",", "and", "C1336827#ent", "<e2>"], "h": {"id": "C1290884", "name": "C1290884#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1336827", "name": "C1336827#ent", "pos": [30, 31]}}
{"token": ["In", "this", "work", ",", "we", "showed", "that", "this", "phosphorylation", "did", "not", "necessitate", "the", "main", "cell", "wall", "sensors", "and", "Mid2p", ",", "but", "was", "abolished", "upon", "deletion", "of", "C1706390#ent", "<e1>", "encoding", "a", "C1366909#ent", "<e2>", "Rho1p", "."], "h": {"id": "C1706390", "name": "C1706390#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1366909", "name": "C1366909#ent", "pos": [30, 31]}}
{"token": ["Two", "of", "the", "genetic", "factors", "to", "this", "syndrome", "are", "the", "major", "histocompatibility", "complex", "C2348924#ent", "<e1>", ")", "and", "a", "Gimap5", "mutation", "(", "C3273648#ent", "<e2>", ")", "responsible", "for", "a", "T-lymphopenia", "."], "h": {"id": "C2348924", "name": "C2348924#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3273648", "name": "C3273648#ent", "pos": [21, 22]}}
{"token": ["Chronic", "obstructive", "pulmonary", "disease", "C1647218#ent", "<e1>", ")", "is", "disabling", ",", "with", "symptoms", "such", "as", "C0744898#ent", "<e2>", "phlegm", ",", "wheezing", ",", "shortness", "of", "breath", "increased", "infections", "of", "the", "respiratory", "passage"], "h": {"id": "C1647218", "name": "C1647218#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0744898", "name": "C0744898#ent", "pos": [14, 15]}}
{"token": ["The", "range", "of", "C0030438#ent", "<e1>", "substrates", "that", "serve", "as", "effective", "C1412050#ent", "<e2>", "substrates", "include", "sterically", "hindered", "aldehydes", "such", "as", "cyclohexanecarboxaldehyde", "and", "pivaldehyde", "."], "h": {"id": "C0030438", "name": "C0030438#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1412050", "name": "C1412050#ent", "pos": [10, 11]}}
{"token": ["Mutations", "of", "the", "bone", "morphogenetic", "protein", "receptor", "II", "BMPR2", ")", "C0017337#ent", "<e1>", "on", "chromosome", "2q33", "cause", "C0340543#ent", "<e2>", "PPH", ")", "and", "may", "occur", "in", "26", "%", "adult", "patients", "with", "sporadic", "disease"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0340543", "name": "C0340543#ent", "pos": [16, 17]}}
{"token": ["When", "HeLa", "cells", "expressing", "HA-tagged", "C3539535#ent", "<e1>", "were", "co-transfected", "with", "active", "C1705341#ent", "<e2>", "or", "stimulated", "with", "IGF-1", ",", "HA-PFK-2", "was", "phosphorylated", "and", "bound", "to", "14", "-", "3", "-", "3s", "."], "h": {"id": "C3539535", "name": "C3539535#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705341", "name": "C1705341#ent", "pos": [11, 12]}}
{"token": ["A", "low", "concentration", "of", "C0022020#ent", "<e1>", "(", "100", "nM", ")", "greatly", "enhanced", "secretion", "stimulated", "by", "C0039542#ent", "<e2>", "or", "by", "8-bromo-cAMP", "but", "only", "had", "an", "additive", "effect", "secretion", "stimulated", "by", "TPA", "."], "h": {"id": "C0022020", "name": "C0022020#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039542", "name": "C0039542#ent", "pos": [15, 16]}}
{"token": ["It", "potentiates", "C1366462#ent", "<e1>", "HAT", "activity", "while", "inhibiting", "those", "of", "p300/CBP", "and", "recombinant", "C1705776#ent", "<e2>", "."], "h": {"id": "C1366462", "name": "C1366462#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705776", "name": "C1705776#ent", "pos": [13, 14]}}
{"token": ["Excellent", "clinical", "efficacy", "obtained", "in", "2/3", "cases", "with", "pneumonia", ",", "3/4", "cases", "with", "C0009443#ent", "<e1>", "2/2", "cases", "with", "cutaneous", "and", "soft", "tissue", "infection", "1/1", "case", "with", "C0262655#ent", "<e2>"], "h": {"id": "C0009443", "name": "C0009443#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0262655", "name": "C0262655#ent", "pos": [26, 27]}}
{"token": ["To", "determine", "how", "BRCA2", "is", "C3889446#ent", "<e1>", "in", "tumors", ",", "we", "investigated", "the", "C1710463#ent", "<e2>", "the", "BRCA2", "promoter", "."], "h": {"id": "C3889446", "name": "C3889446#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1710463", "name": "C1710463#ent", "pos": [13, 14]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "identify", "membrane", "proteins", "PMNs", ",", "and/or", "C0268731#ent", "<e1>", "as", "additional", "C1413096#ent", "<e2>", "ANCA", "targets", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1413096", "name": "C1413096#ent", "pos": [17, 18]}}
{"token": ["IL-1", "alpha", "but", "not", "thrombin", ",", "activated", "C0812215#ent", "<e1>", "as", "assessed", "by", "immune-complex", "kinase", "assay", ",", "as", "did", "C0297666#ent", "<e2>", "alone", "."], "h": {"id": "C0812215", "name": "C0812215#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0297666", "name": "C0297666#ent", "pos": [18, 19]}}
{"token": ["In", "contrast", ",", "C1414134#ent", "<e1>", "(", "0.01", ",", "0.1", "and", "1", "microM", ")", "did", "not", "significantly", "stimulate", "C0162745#ent", "<e2>", "or", "TIMP", "levels", ",", "indicating", "that", "C1414134#ent", "<e1>", "may", "not", "interact", "with", "osteoblasts", "."], "h": {"id": "C0162745", "name": "C0162745#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414134", "name": "C1414134#ent", "pos": [3, 4]}}
{"token": ["The", "authors", "describe", "their", "experience", ",", "using", "this", "approach", ",", "in", "herpetic", "encephalitis", "acute", "and", "recurrent", "herpetic", "meningitis", ",", "C0008049#ent", "<e1>", "zoster-induced", "neurological", "diseases", ",", "C0341335#ent", "<e2>", "progressive", "multifocal", "leukoencephalitis", "tuberculous", "meningitis"], "h": {"id": "C0008049", "name": "C0008049#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0341335", "name": "C0341335#ent", "pos": [25, 26]}}
{"token": ["Western", "immunoblotting", "analysis", "significantly", "higher", "approximately", "40", "%", ")", "levels", "of", "sarco(endo)plasmic", "reticulum", "Ca2+-ATPase", "2", "(", "C0916183#ent", "<e1>", ")", "in", "JSR", ",", "but", "not", "in", "C1825916#ent", "<e2>", ",", "from", "hyperthyroid", "than", "from", "euthyroid", "rabbit", "heart"], "h": {"id": "C0916183", "name": "C0916183#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1825916", "name": "C1825916#ent", "pos": [25, 26]}}
{"token": ["This", "may", "result", "in", "organ", "dysfunction", "organ", "failure", "C0036690#ent", "<e1>", ",", "since", "increased", "C0030306#ent", "<e2>", "plasma", "levels", "correlate", "with", "the", "mortality", "rate", "patients", "with", "C0036690#ent", "<e1>", "."], "h": {"id": "C0036690", "name": "C0036690#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0030306", "name": "C0030306#ent", "pos": [13, 14]}}
{"token": ["Furthermore", "the", "purified", "inhibitor", "reacted", "with", "orcinol", "but", "not", "with", "C0012528#ent", "<e1>", ",", "and", "its", "inhibitory", "activity", "completely", "destroyed", "by", "treatment", "with", "C0085431#ent", "<e2>", "."], "h": {"id": "C0012528", "name": "C0012528#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0085431", "name": "C0085431#ent", "pos": [22, 23]}}
{"token": ["To", "understand", "the", "status", "of", "the", "HPA", "axis", "during", "this", "phase", "of", "C0019693#ent", "<e1>", "25", "non-AIDS", "ambulatory", "patients", "with", "advanced", "C0019693#ent", "<e1>", "without", "evidence", "of", "adrenal", "or", "C0020635#ent", "<e1>", "studied", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020635", "name": "C0020635#ent", "pos": [27, 28]}}
{"token": ["The", "present", "study", "was", "designed", "to", "assess", "pain", "score", "documentation", "and", "provision", "of", "C0242937#ent", "<e1>", "children", "and", "adults", "with", "confirmed", "C0003615#ent", "<e2>", "in", "a", "mixed", "Australian", "ED", "."], "h": {"id": "C0242937", "name": "C0242937#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003615", "name": "C0003615#ent", "pos": [20, 21]}}
{"token": ["Radical", "surgery", "be", "considered", "in", "cases", "with", "C1420259#ent", "<e1>", "who", "recurred", "C0025297#ent", "<e2>"], "h": {"id": "C1420259", "name": "C1420259#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [11, 12]}}
{"token": ["Although", "recurrent", "C0024116#ent", "<e1>", "pulmonary", "insufficiency", "the", "principal", "causes", "of", "morbidity", "and", "death", ",", "C0426575#ent", "<e2>", "precede", "the", "pulmonary", "findings", "may", "suggest", "the", "diagnosis", "in", "infants", "and", "young", "children", "."], "h": {"id": "C0024116", "name": "C0024116#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0426575", "name": "C0426575#ent", "pos": [14, 15]}}
{"token": ["C2936882#ent", "<e1>", "significantly", "inhibited", "the", "LPS-induced", "increase", "in", "C2986464#ent", "<e2>", "cerebral", "vessels", "animals", "at", "both", "ages", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2986464", "name": "C2986464#ent", "pos": [8, 9]}}
{"token": ["Whereas", "PKD", "has", "been", "the", "focus", "of", "most", "studies", ",", "virtually", "nothing", "is", "known", "about", "the", "effect", "of", "G", "protein-coupled", "receptor", "agonists", "C1428424#ent", "<e1>", ")", "on", "the", "regulatory", "properties", "intracellular", "distribution", "of", "C1418603#ent", "<e2>", "."], "h": {"id": "C1428424", "name": "C1428424#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1418603", "name": "C1418603#ent", "pos": [32, 33]}}
{"token": ["CR", "decreases", "the", "C0151449#ent", "<e1>", "inflammation", "of", "C0036091#ent", "<e2>", "B/W", "animals", "while", "increasing", "expression", "of", "the", "immunosuppressive", "cytokine", "TGF\u03b21", "decreasing", "expression", "of", "the", "pro-inflammatory", "cytokines", "IL-6", "and", "TNF\u03b1", "."], "h": {"id": "C0151449", "name": "C0151449#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0036091", "name": "C0036091#ent", "pos": [7, 8]}}
{"token": ["C0008429#ent", "<e1>", "are", "measured", "to", "assess", "exposures", "to", "or", "effects", "of", "organophosphorus", "esters", "C3540024#ent", "<e2>", "."], "h": {"id": "C0008429", "name": "C0008429#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540024", "name": "C3540024#ent", "pos": [13, 14]}}
{"token": ["Ectopic", "Shh", "suppressed", "expression", "of", "Bone", "Morphogenetic", "Protein", "4", "C1412805#ent", "<e1>", ")", "in", "the", "dorsal", "retina", "whereas", "reducing", "endogenous", "C1335824#ent", "<e2>", "resulted", "in", "a", "ventral", "expansion", "C1412805#ent", "<e1>", "territory", "."], "h": {"id": "C1412805", "name": "C1412805#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335824", "name": "C1335824#ent", "pos": [19, 20]}}
{"token": ["Enamel", "matrix", "serine", "proteinase", "1", "C1833662#ent", "<e1>", ")", ",", "now", "officially", "designated", "C1416675#ent", "<e2>", "KLK4", ")", ",", "is", "believed", "to", "be", "the", "predominant", "degradative", "enzyme", "clears", "enamel", "proteins", "the", "matrix", "during", "maturation", "."], "h": {"id": "C1833662", "name": "C1833662#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416675", "name": "C1416675#ent", "pos": [12, 13]}}
{"token": ["These", "studies", "also", "identified", "two", "identical", "sequences", "(", "GCAGGA", ")", "flanking", "C3889388#ent", "<e1>", ",", "termed", "the", "binding", "CRALBP", "element", "(", "C1705334#ent", "<e2>", ")", ",", "that", "are", "also", "important", "for", "complex", "formation", "."], "h": {"id": "C3889388", "name": "C3889388#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705334", "name": "C1705334#ent", "pos": [20, 21]}}
{"token": ["The", "antifungal", "activity", "sertaconazole", "(", "SZ", ")", ",", "1-(2-[(7-chlorobenzo[b]thien-3-yl)methoxyl]-", "2-(2,4-dichlorophenyl)ethyl)-1H-imidazole", ",", "has", "been", "assessed", "in", "vivo", "comparison", "with", "C0025942#ent", "<e1>", "(", "MZ", ")", "in", "a", "murine", "C0700345#ent", "<e2>", "model", "."], "h": {"id": "C0025942", "name": "C0025942#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0700345", "name": "C0700345#ent", "pos": [26, 27]}}
{"token": ["In", "this", "tissue", "C0340861#ent", "<e1>", "was", "deaminated", "by", "the", "A", "form", "of", "the", "C0027203#ent", "<e2>", "."], "h": {"id": "C0340861", "name": "C0340861#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}}
{"token": ["Blocking", "hyperploid", "progression", "through", "C0020402#ent", "<e1>", "or", "ectopically", "expressed", ")", ",", "a", "G1-specific", "Cdk", "inhibitor", "abrogates", "C0242383#ent", "<e2>", "cytotoxicity", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242383", "name": "C0242383#ent", "pos": [16, 17]}}
{"token": ["Carbidopa", "administered", "before", "the", "second", "C0011777#ent", "<e1>", "dose", "blunted", "both", "the", "C0012798#ent", "<e2>", "and", "the", "natriuretic", "response", "haloperidol", "abolished", "or", "blunted", "all", "the", "effects", "of", "the", "second", "C0011777#ent", "<e1>", "dose", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012798", "name": "C0012798#ent", "pos": [11, 12]}}
{"token": ["In", "all", "transformants", ",", "C1417732#ent", "<e1>", "mRNA", "and", "C0028123#ent", "<e2>", "activity", "were", "repressed", "in", "cells", "grown", "on", "ammonium", "medium", ",", "showing", "that", "expression", "of", "the", "integrated", "nit1", "genes", "regulated", "normally", "."], "h": {"id": "C1417732", "name": "C1417732#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0028123", "name": "C0028123#ent", "pos": [8, 9]}}
{"token": ["We", "believe", "that", "in", "this", "patient", "C1538440#ent", "<e1>", "led", "to", "the", "pathogenesis", "of", "C2931384#ent", "<e2>"], "h": {"id": "C1538440", "name": "C1538440#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2931384", "name": "C2931384#ent", "pos": [13, 14]}}
{"token": ["By", "maintaining", "high", "ectopic", "expression", "of", "C1417833#ent", "<e1>", "in", "preplate", "cells", "we", "show", "that", "C1417833#ent", "<e1>", "represses", "the", "CR", "cell", "markers", "C1419337#ent", "<e1>", "and", "calretinin", ",", "and", "with", "lower", "efficiency", "the", "transcription", "factor", "Tbr1"], "h": {"id": "C1417833", "name": "C1417833#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1419337", "name": "C1419337#ent", "pos": [21, 22]}}
{"token": ["A", "patient", "presented", "with", "decreased", "visual", "acuity", "retinal", "findings", "compatible", "with", "C0730330#ent", "<e1>", "years", "after", "discontinuing", "regular", "usage", "of", "C0055461#ent", "<e2>", "for", "rheumatoid", "arthritis"], "h": {"id": "C0730330", "name": "C0730330#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [19, 20]}}
{"token": ["In", "order", "to", "investigate", "C0730330#ent", "<e1>", "the", "effect", "of", "C0055461#ent", "<e2>", "on", "the", "viability", "and", "differentiation", "of", "primary", "cell", "cultures", "embryonic", "chick", "neuronal", "retina", "retinal", "pigment", "epithelium", "RPE", ")", ",", "brain", "and", "meninges", "were", "investigated", "."], "h": {"id": "C0730330", "name": "C0730330#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0055461", "name": "C0055461#ent", "pos": [9, 10]}}
{"token": ["The", "pseudoautosomal", "regions", "C1414437#ent", "<e1>", ")", "pair", "and", "C0073020#ent", "<e2>", "during", "meiosis", "like", "autosomes", ",", "but", "the", "recombination", "activity", "PAR1", "is", "extremely", "different", "between", "sexes", "."], "h": {"id": "C1414437", "name": "C1414437#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0073020", "name": "C0073020#ent", "pos": [8, 9]}}
{"token": ["Dopamine-depleting", "lesions", "increased", "the", "density", "of", "D2", "receptors", "the", "denervated", "neostriatum", "29", "%", "without", "C2712370#ent", "<e1>", "the", "affinity", "of", "the", "receptors", "for", "C0037956#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0037956", "name": "C0037956#ent", "pos": [22, 23]}}
{"token": ["A", "37-year-old", "female", "developed", "C0014742#ent", "<e1>", "days", "after", "beginning", "carbamazepine", "for", "complex", "partial", "C0751495#ent", "<e2>", "."], "h": {"id": "C0014742", "name": "C0014742#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [13, 14]}}
{"token": ["Activities", "of", "C0018358#ent", "<e1>", "platelet", "homogenate", "cytosolic", "fraction", "activated", "by", "C2714964#ent", "<e2>", ",", "whereas", "particulate", "guanylate", "cyclase", "activity", "unaffected", "."], "h": {"id": "C0018358", "name": "C0018358#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2714964", "name": "C2714964#ent", "pos": [10, 11]}}
{"token": ["C0020223#ent", "<e1>", "and", "labetalol", "are", "the", "safest", "C0035064#ent", "<e2>", ",", "but", "they", "are", "inadequate", "to", "control", "blood", "pressure", "some", "women", "."], "h": {"id": "C0020223", "name": "C0020223#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [7, 8]}}
{"token": ["The", "C1709545#ent", "<e1>", "reported", "earlier", "to", "have", "significant", "anti-oxidant", "effect", "C0040616#ent", "<e2>", "improve", "memory", "retention", "Alzheimer's", "disease"], "h": {"id": "C1709545", "name": "C1709545#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0040616", "name": "C0040616#ent", "pos": [10, 11]}}
{"token": ["We", "report", "here", "the", "first", "case", ",", "to", "our", "knowledge", ",", "of", "a", "C0270639#ent", "<e1>", "complicating", "a", "nephrotic", "syndrome", "minimal", "C0268731#ent", "<e2>", "changes", "."], "h": {"id": "C0270639", "name": "C0270639#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [20, 21]}}
{"token": ["C3539609#ent", "<e1>", "has", "recently", "been", "recognized", "as", "a", "small", "ubiquitin-like", "modifier", "SUMO", ")", "C1334397#ent", "<e2>", "."], "h": {"id": "C3539609", "name": "C3539609#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334397", "name": "C1334397#ent", "pos": [13, 14]}}
{"token": ["Mutations", "in", "the", "sodium", "channel", "genes", "SCN1A", "and", "SCN2A", "have", "been", "identified", "in", "monogenic", "childhood", "epilepsies", "but", "C1419861#ent", "<e1>", "has", "not", "previously", "been", "investigated", "as", "a", "candidate", "C0017337#ent", "<e2>", "for", "epilepsy", "."], "h": {"id": "C1419861", "name": "C1419861#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [27, 28]}}
{"token": ["Osteonecrosis", "(", "C2985244#ent", "<e1>", ")", "is", "a", "well-known", "complication", "in", "patients", "with", "systemic", "lupus", "erythematosus", "C0014060#ent", "<e2>", ")", "often", "associated", "with", "steroid", "therapy"], "h": {"id": "C2985244", "name": "C2985244#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014060", "name": "C0014060#ent", "pos": [15, 16]}}
{"token": ["We", "show", "here", "that", "TAC", "in", "mice", "C1516876#ent", "<e1>", "engineered", "to", "lack", "C1418779#ent", "<e2>", "leads", "to", "accelerated", "cardiac", "dysfunction", "which", "is", "accompanied", "by", "signs", "of", "significant", "clinical", "heart", "failure"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418779", "name": "C1418779#ent", "pos": [12, 13]}}
{"token": ["An", "open-controlled", "trial", "performed", "in", "C0038358#ent", "<e1>", "cases", "resistant", "to", "previous", "C0008783#ent", "<e2>", ",", "antacids", ",", "vitamin", "A", "polyvinylbutylether", "therapy", "applied", "for", "at", "least", "4", "weeks", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [11, 12]}}
{"token": ["C0015278#ent", "<e1>", "are", "cellular", "enzymes", ",", "able", "to", "split", "the", "C0032594#ent", "<e2>", "into", "glucose", "."], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [10, 11]}}
{"token": ["Our", "data", "suggest", "that", "loss", "of", "AP-2", "in", "metastatic", "cells", "C2712370#ent", "<e1>", "the", "AP-2/Sp1", "ratio", ",", "resulting", "in", "overexpression", "of", "C1705939#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705939", "name": "C1705939#ent", "pos": [20, 21]}}
{"token": ["C1705240#ent", "<e1>", ",", "calculated", "from", "the", "ratio", "of", "and", "C3272787#ent", "<e2>", ",", "was", "1.2", "+", "/-", "0.3", "nM", ",", "a", "value", "close", "to", "that", "calculated", "from", "Scatchard", "plots", "of", "binding", "isotherms", "."], "h": {"id": "C1705240", "name": "C1705240#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3272787", "name": "C3272787#ent", "pos": [9, 10]}}
{"token": ["Limiting-dilution", "reverse", "transcription-PCR", "confirmed", "that", "these", "changes", "in", "C3273671#ent", "<e1>", "expression", "occurred", "in", "clinical", "isolates", "uropathogenic", "Escherichia", "coli", "in", "media", "with", "different", "C0265220#ent", "<e2>", "and", "different", "osmolarities", "."], "h": {"id": "C3273671", "name": "C3273671#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0265220", "name": "C0265220#ent", "pos": [22, 23]}}
{"token": ["Here", ",", "using", "cultured", "mouse", "hepatocytes", "isolated", "from", "C2984537#ent", "<e1>", "null", "mice", "we", "have", "examined", "the", "role", "of", "the", "peroxisome", "proliferator", "activated", "receptor", "alpha", "C2984537#ent", "<e1>", ")", "in", "mediating", "the", "suppression", "of", "apoptosis", "caused", "by", "C2697656#ent", "<e1>", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [35, 36]}}
{"token": ["These", "data", "confirm", "the", "dependence", "of", "the", "response", "to", "C2697656#ent", "<e1>", "on", "C2984537#ent", "<e2>", "by", "demonstrating", "that", "C2984537#ent", "<e2>", "mediates", "the", "suppression", "of", "hepatocyte", "apoptosis", "in", "response", "to", "C2697656#ent", "<e1>", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}}
{"token": ["PEG", "C1456390#ent", "<e1>", "revealed", "significant", "differences", "between", "the", "effects", "of", "EGTA", "and", "C0142815#ent", "<e2>", "C10", ")", "."], "h": {"id": "C1456390", "name": "C1456390#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0142815", "name": "C0142815#ent", "pos": [12, 13]}}
{"token": ["Introducing", "GATA-3", "into", "Stat6-deficient", "T", "cells", "completely", "restored", "Th2", "development", ",", "inducing", "c-Maf", ",", "Th2-specific", "C0011519#ent", "<e1>", "hypersensitive", "sites", "the", "IL-4", "locus", ",", "and", "Th2", "C1333196#ent", "<e2>", "expression", "."], "h": {"id": "C0011519", "name": "C0011519#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [25, 26]}}
{"token": ["C0242913#ent", "<e1>", "be", "safest", "to", "administer", "to", "patients", "without", "C0010054#ent", "<e2>", "but", "the", "oxygen-consuming", "effect", "of", "these", "drugs", "need", "not", "necessarily", "have", "an", "adverse", "effect", "patients", "with", "ischemic", "heart", "disease"], "h": {"id": "C0242913", "name": "C0242913#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [9, 10]}}
{"token": ["Serum", "C1537986#ent", "<e1>", "declined", "in", "C2316810#ent", "<e2>", ",", "but", "not", "in", "control", "subjects", "while", "glucose", "levels", "not", "different", "in", "the", "two", "groups", "."], "h": {"id": "C1537986", "name": "C1537986#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [5, 6]}}
{"token": ["Overxpression", "of", "inhibitory", "C1305923#ent", "<e1>", "that", "block", "signals", "generated", "from", "C0034678#ent", "<e2>", "and", "Cdc42", "was", "found", "to", "reverse", "the", "retinoic", "acid", "induction", "of", "GST", "expression", "in", "PC12", "cells"], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034678", "name": "C0034678#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "Hsp105alpha", "was", "found", "to", "localize", "in", "nuclear", "inclusions", "by", "ARs", "containing", "an", "expanded", "C0392213#ent", "<e1>", "tissues", "of", "patients", "and", "transgenic", "mice", "C1839259#ent", "<e2>", "."], "h": {"id": "C0392213", "name": "C0392213#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [23, 24]}}
{"token": ["These", "data", "indicate", "that", "two", "conditions", "must", "be", "satisfied", "to", "observe", "glial", "C0242912#ent", "<e1>", ":", "maturation", "of", "C0017801#ent", "<e2>", "expression", ",", "and", "neuron-glial", "signalling", "through", "glutamate-elicited", "responses", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017801", "name": "C0017801#ent", "pos": [17, 18]}}
{"token": ["Hypoxia", "also", "reduced", "hENT1", "protein", "mRNA", "levels", ",", "effects", "unaltered", "by", "N(omega)-nitro-l-arginine", "methyl", "ester", "l-NAME", ",", "C0132555#ent", "<e1>", "NOS", "]", "inhibitor", ")", "or", "PD-98059", "(", "inhibitor", "of", "C1334474#ent", "<e2>", "2", "[", "MEK1/2", "]", ")", "."], "h": {"id": "C0132555", "name": "C0132555#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [27, 28]}}
{"token": ["Overall", "results", "indicate", "the", "effect", "of", "increasing", "severity", "of", "riboflavin", "deficiency", "greater", "with", "flavokinase", ",", "which", "is", "physiologically", "rate-limiting", "in", "the", "biosynthesis", "of", "C1258127#ent", "<e1>", ",", "than", "with", "C1825303#ent", "<e2>"], "h": {"id": "C1258127", "name": "C1258127#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1825303", "name": "C1825303#ent", "pos": [28, 29]}}
{"token": ["Hormones", "such", "as", "C1418938#ent", "<e1>", "and", "leptin", "have", "recently", "been", "recognized", "as", "potent", "platelet", "aggregation", "C3275267#ent", "<e2>", ",", "and", "have", "therefore", "been", "postulated", "as", "an", "additional", "risk", "factor", "both", "arterial", "and", "venous", "thrombosis"], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3275267", "name": "C3275267#ent", "pos": [15, 16]}}
{"token": ["Tamoxifen", "allows", "strong", "C1419034#ent", "<e1>", "activity", ",", "whereas", "C0618111#ent", "<e2>", "allows", "less", "and", "ICI", "182,780", "ICI", ")", "allows", "none", "."], "h": {"id": "C1419034", "name": "C1419034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0618111", "name": "C0618111#ent", "pos": [8, 9]}}
{"token": ["These", "cases", "are", "thought", "to", "be", "caused", "by", "C0014473#ent", "<e1>", "due", "to", "C0042769#ent", "<e2>"], "h": {"id": "C0014473", "name": "C0014473#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [12, 13]}}
{"token": ["The", "data", "suggest", "that", "the", "bacterial", "C0388638#ent", "<e1>", "fails", "to", "act", "as", "a", "C0040676#ent", "<e2>", "because", "it", "hydrolyzes", "the", "transphosphatidylation", "products", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0040676", "name": "C0040676#ent", "pos": [13, 14]}}
{"token": ["Somatostatin", "analogue", "octreotide", ")", "treatment", "initiated", "at", "the", "onset", "of", "C0011847#ent", "<e1>", "prevents", "kidney", "C1334089#ent", "<e2>", "accumulation", "and", "renal", "growth"], "h": {"id": "C0011847", "name": "C0011847#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [14, 15]}}
{"token": ["We", "have", "described", "a", "28-year-old", "male", "sheepfarmer", "who", "had", "fever", ",", "C0018681#ent", "<e1>", ",", "chills", ",", "malaise", ",", "and", "C0158617#ent", "<e2>"], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0158617", "name": "C0158617#ent", "pos": [19, 20]}}
{"token": ["The", "VHL", "tumor", "suppressor", "protein", "C0299505#ent", "<e1>", ")", "is", "part", "of", "an", "C1418270#ent", "<e2>", "targets", "HIF", "for", "destruction", "."], "h": {"id": "C0299505", "name": "C0299505#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [12, 13]}}
{"token": ["It", "is", "suggested", "that", "the", "same", "pathogenetic", "factors", "operate", "in", "the", "C4255166#ent", "<e1>", "of", "gastric", "carcinoid", "gastric", "carcinoma", "patients", "with", "C0002892#ent", "<e2>"], "h": {"id": "C4255166", "name": "C4255166#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0002892", "name": "C0002892#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "C0598034#ent", "<e1>", "may", "have", "chromatin", "modifying", "activity", "through", "interaction", "with", "a", "C0671924#ent", "<e2>", "p300/CBP-associated", "factor", "P/CAF", ")", "."], "h": {"id": "C0598034", "name": "C0598034#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0671924", "name": "C0671924#ent", "pos": [14, 15]}}
{"token": ["Recent", "research", "has", "suggested", "that", "the", "C0012236#ent", "<e1>", "region", "gene", "14", "(", "C2697539#ent", "<e2>", ")", "exhibits", "activity", "differences", "of", "more", "than", "1.5", "fold", "between", "the", "haplotypes", "of", "the", "variants", "in", "the", "promoter", "region"], "h": {"id": "C0012236", "name": "C0012236#ent", "pos": [6, 7]}, "relation": "disease_has_associated_gene", "t": {"id": "C2697539", "name": "C2697539#ent", "pos": [12, 13]}}
{"token": ["The", "expression", "of", "C0065661#ent", "<e1>", "mRNA", "was", "up-regulated", "by", "C2697656#ent", "<e2>", "challenge", "after", "18", "days", "post", "fertilization", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}}
{"token": ["Understanding", "patterns", "of", "linkage", "disequilibrium", "LD", ")", "across", "C0242965#ent", "<e1>", "may", "facilitate", "association", "mapping", "studies", "localize", "genetic", "variants", "C0020951#ent", "<e2>", "a", "recognition", "that", "led", "to", "the", "International", "Haplotype", "Mapping", "Project", "(", "HapMap", ")", "."], "h": {"id": "C0242965", "name": "C0242965#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020951", "name": "C0020951#ent", "pos": [18, 19]}}
{"token": ["The", "differentiation", "of", "HL-60", "cells", "induced", "by", "all-trans", "retinoic", "acid", "C0012403#ent", "<e1>", "phorbol-12-myristate", "13-acetate", "also", "enhanced", "by", "C0014963#ent", "<e2>", "increasing", "NBT-reducing", "and", "lysozyme", "activities", "and", "the", "expression", "of", "CD11b", "or", "CD14", "surface", "antigen"], "h": {"id": "C0012403", "name": "C0012403#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0014963", "name": "C0014963#ent", "pos": [17, 18]}}
{"token": ["These", "results", "illustrate", "the", "molecular", "mechanism", "which", "C1415343#ent", "<e1>", "efficiently", "recruits", "FCP1", "to", "the", "pol", "II", "transcription", "machinery", "recycling", "of", "the", "C1335440#ent", "<e2>", "."], "h": {"id": "C1415343", "name": "C1415343#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [21, 22]}}
{"token": ["Spinocerebellar", "ataxia", "type", "10", "an", "C3899989#ent", "<e1>", "by", "ataxia", "and", "C0751495#ent", "<e2>", ",", "is", "caused", "by", "a", "large", "expansion", "of", "an", "unstable", "ATTCT", "pentanucleotide", "repeat", "."], "h": {"id": "C3899989", "name": "C3899989#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [10, 11]}}
{"token": ["There", "is", "now", "extensive", "experience", "in", "the", "use", "of", "several", "of", "the", "low-molecular-weight", "heparins", "particularly", "C0282471#ent", "<e1>", "and", "enoxaparin", ",", "in", "the", "management", "of", "patients", "with", "C0002965#ent", "<e2>"], "h": {"id": "C0282471", "name": "C0282471#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [26, 27]}}
{"token": ["5", "Propranolol", "and", "phenoxybenzamine", "had", "no", "effect", "the", "C4255305#ent", "<e1>", "action", "of", "C0012695#ent", "<e2>", "."], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0012695", "name": "C0012695#ent", "pos": [12, 13]}}
{"token": ["The", "nonsulfated", "mammary", "C0169362#ent", "<e1>", "unable", "to", "interact", "with", "C1335808#ent", "<e2>", "consistent", "with", "hypothesis", "that", "milk", "C0169362#ent", "<e1>", "a", "different", "function", "than", "endothelial", "GlyCAM", "1"], "h": {"id": "C0169362", "name": "C0169362#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335808", "name": "C1335808#ent", "pos": [9, 10]}}
{"token": ["In", "the", "reverse", "library", "C0017337#ent", "<e1>", "that", "encoded", "CD59/neurotoxin/Ly-6-like", "protein", ",", "C1258086#ent", "<e2>", "and", "goose-type", "lysozyme", "were", "down-regulated", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1258086", "name": "C1258086#ent", "pos": [11, 12]}}
{"token": ["A", "retrospective", "controlled", "study", "a", "variety", "of", "C0003374#ent", "<e1>", "and", "a", "randomized", "discontinuation", "trial", "of", "C0596007#ent", "<e2>", "support", "the", "considerable", "clinical", "belief", "that", "C0003374#ent", "<e1>", "are", "of", "benefit", "in", "mild-to-moderate", "SLE", "."], "h": {"id": "C0596007", "name": "C0596007#ent", "pos": [15, 16]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [7, 8]}}
{"token": ["The", "nuclear", "localization", "signal", "the", "boundary", "between", "C1424868#ent", "<e1>", "and", "the", "hinge", "region", "in", "the", "association", "of", "AR", "with", "C1420299#ent", "<e2>", ",", "and", "a", "receptor", "mutant", "the", "C-terminal", "part", "the", "bipartite", "nuclear", "localization", "signal", "attenuated", "response", "to", "coexpressed", "C1420299#ent", "<e2>", "."], "h": {"id": "C1424868", "name": "C1424868#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420299", "name": "C1420299#ent", "pos": [19, 20]}}
{"token": ["Autosomal-dominant", ",", "C1384666#ent", "<e1>", "clinically", "and", "C1516876#ent", "<e2>", "heterogeneous", "."], "h": {"id": "C1384666", "name": "C1384666#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [6, 7]}}
{"token": ["Nitroblue", "tetrazolium", "NBT", ")", "in", "the", "presence", "of", "phenazine", "methosulfate", "C1868117#ent", "<e1>", ")", "reacts", "with", "the", "NADPH", "produced", "by", "C0022917#ent", "<e2>", "to", "produce", "an", "insoluble", "blue-purple", "formazan", "."], "h": {"id": "C1868117", "name": "C1868117#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0022917", "name": "C0022917#ent", "pos": [19, 20]}}
{"token": ["Effects", "of", "nipradilol", ",", "a", "C0304512#ent", "<e1>", "a", "nitroxy", "moiety", ",", "on", "C0251211#ent", "<e2>", "PEPCK", ")", "gene", "transcription", "examined", "using", "a", "rat", "hepatoma", "cell", "line", "H4IIE", "cells", "."], "h": {"id": "C0304512", "name": "C0304512#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0251211", "name": "C0251211#ent", "pos": [12, 13]}}
{"token": ["Increased", "levels", "of", "immunoglobulin", "D", "IgD", ")", "and", ",", "in", "most", "patients", "of", "immunoglobulin", "A", "IgA", ")", ",", "in", "combination", "with", "enhanced", "excretion", "of", "C0342731#ent", "<e1>", "strong", "evidence", "for", "C0342731#ent", "<e1>", "."], "h": {"id": "C0342731", "name": "C0342731#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0342731", "name": "C0342731#ent", "pos": [24, 25]}}
{"token": ["C3538766#ent", "<e1>", "synergized", "with", "3", "other", "receptors", ",", "C3538763#ent", "<e2>", "and", "DNAM-1", "each", "synergized", "with", "2", "other", "receptors", ",", "and", "CD2", "synergized", "with", "NKp46", "only", "."], "h": {"id": "C3538766", "name": "C3538766#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538763", "name": "C3538763#ent", "pos": [8, 9]}}
{"token": ["The", "presence", "of", "C0733398#ent", "<e1>", "(", "10(-4", ")", "M", ")", "completely", "blocked", "the", "strip", "response", "C0340861#ent", "<e2>", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0340861", "name": "C0340861#ent", "pos": [15, 16]}}
{"token": ["We", "found", "in", "the", "present", "study", "that", "LMW", "slow", "C2240312#ent", "<e1>", "was", "significantly", "upregulated", "in", "demyelination", "form", "type", "1", "CMT", "C2698698#ent", "<e2>", ")", "but", "not", "axonal", "form", "type", "2", "CMT", "CMT2", ")", "muscles", "."], "h": {"id": "C2240312", "name": "C2240312#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2698698", "name": "C2698698#ent", "pos": [20, 21]}}
{"token": ["C0162568#ent", "<e1>", "complicated", "by", "C0023892#ent", "<e2>", "progressive", "hepatic", "failure", "10", "%", ",", "of", "patients", "."], "h": {"id": "C0162568", "name": "C0162568#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023892", "name": "C0023892#ent", "pos": [4, 5]}}
{"token": ["C3538938#ent", "<e1>", ",", "which", "is", "also", "called", "as", "C1412456#ent", "<e2>", "or", "mammalian", "Lin10", ",", "protein", "has", "been", "implicated", "in", "the", "synaptic", "vesicle", "exocytosis", "and", "the", "targeting", "and", "localization", "of", "synaptic", "membrane", "proteins"], "h": {"id": "C3538938", "name": "C3538938#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412456", "name": "C1412456#ent", "pos": [8, 9]}}
{"token": ["C1435846#ent", "<e1>", "TAB1", ")", "binds", "and", "induces", "autophosphorylation", "of", "TGF-beta", "activating", "kinase", "C1334477#ent", "<e2>", ")", "."], "h": {"id": "C1435846", "name": "C1435846#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1334477", "name": "C1334477#ent", "pos": [12, 13]}}
{"token": ["When", "unresolved", "C0004659#ent", "<e1>", "is", "caused", "by", "organisms", "sensitive", "to", "the", "initial", "antimicrobial", "therapy", "C0554309#ent", "<e2>", "or", "a", "large", "bacterial", "mass", "density", "be", "suspected", "."], "h": {"id": "C0004659", "name": "C0004659#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0554309", "name": "C0554309#ent", "pos": [14, 15]}}
{"token": ["As", "assessed", "by", "echocardiography", ",", "C1413134#ent", "<e1>", "mice", "at", "7", "weeks", "showed", "C0162770#ent", "<e2>", "mild", "decreased", "fractional", "shortening", "increased", "wall", "thickness"], "h": {"id": "C1413134", "name": "C1413134#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0162770", "name": "C0162770#ent", "pos": [12, 13]}}
{"token": ["However", ",", "within", "the", "nucleus", "basalis", "Meynert", ",", "the", "large", "cholinergic", "neurons", "expressed", "C1707622#ent", "<e1>", "mRNA", ",", "but", "the", "neurons", "producing", "C1418457#ent", "<e2>", "expressed", "neither", "D1R", "nor", "C1707622#ent", "<e1>", "mRNA", "."], "h": {"id": "C1707622", "name": "C1707622#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418457", "name": "C1418457#ent", "pos": [21, 22]}}
{"token": ["Immunohistochemical", "analyses", "that", "C1707622#ent", "<e1>", "and", "D3R", "GFP", "fluorescent", "cells", "colocalized", "with", "C1418457#ent", "<e2>", "and", "substance", "P", "medium", "spiny", "neurons", "."], "h": {"id": "C1707622", "name": "C1707622#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418457", "name": "C1418457#ent", "pos": [12, 13]}}
{"token": ["With", "an", "emphasis", "on", "population", "subdivision", "the", "goal", "of", "this", "paper", "is", "to", "investigate", "the", "causes", "of", "linkage", "disequilibrium", "C4083146#ent", "<e1>", ",", "the", "gene", "that", "encodes", "C1412335#ent", "<e2>"], "h": {"id": "C4083146", "name": "C4083146#ent", "pos": [19, 20]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1412335", "name": "C1412335#ent", "pos": [26, 27]}}
{"token": ["In", "C0263374#ent", "<e1>", "senescent", "lichenoid", "patterns", "resemble", "those", "seen", "in", "C0162849#ent", "<e2>"], "h": {"id": "C0263374", "name": "C0263374#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0162849", "name": "C0162849#ent", "pos": [10, 11]}}
{"token": ["Some", "clinical", "reports", "C0242911#ent", "<e1>", ",", "antidepressant", "and", "prophylactic", "effects", "C0006949#ent", "<e2>", "(", "CBZ", ")", "in", "manic-depressive", "illness", "appeared", "since", "its", "initial", "use", "as", "an", "anticonvulsant", "drug"], "h": {"id": "C0242911", "name": "C0242911#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0006949", "name": "C0006949#ent", "pos": [10, 11]}}
{"token": ["This", "study", "provides", "insights", "into", "the", "properties", "of", "different", "activities", "involved", "in", "protein", "ectodomain", "shedding", "and", "has", "implications", "for", "the", "functional", "regulation", "of", "C1367028#ent", "<e1>", "by", "potentially", "more", "than", "one", "C1947941#ent", "<e2>", "."], "h": {"id": "C1367028", "name": "C1367028#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [30, 31]}}
{"token": ["In", "particular", ",", "p53", "promoted", "mdm2", ",", "C1420626#ent", "<e1>", ",", "puma", "and", "C1705517#ent", "<e2>", "expression", "in", "PC12", "cells"], "h": {"id": "C1420626", "name": "C1420626#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705517", "name": "C1705517#ent", "pos": [12, 13]}}
{"token": ["Liquid", "chromatography", "tandem", "mass", "spectrometry", "MS-MS", ")", "analysis", "of", "human", "Keap1", "modified", "by", "IAB", "or", "C1826727#ent", "<e1>", "in", "vitro", "that", "IAB", "adduction", "occurred", "primarily", "in", "the", "central", "linker", "domain", ",", "whereas", "C1826727#ent", "<e1>", "modified", "other", "C1427969#ent", "<e1>"], "h": {"id": "C1826727", "name": "C1826727#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1427969", "name": "C1427969#ent", "pos": [35, 36]}}
{"token": ["We", "conclude", "that", "C0022104#ent", "<e1>", "a", "chronic", "relapsing", "disorder", "that", "treatment", "with", "a", "combination", "of", "ispaghula", "husk", "C0033448#ent", "<e2>", "is", "effective", ",", "both", "in", "relieving", "symptoms", "and", "in", "the", "maintenance", "of", "remission", "."], "h": {"id": "C0022104", "name": "C0022104#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0033448", "name": "C0033448#ent", "pos": [17, 18]}}
{"token": ["Clinically", ",", "backward", "falls", "C0277845#ent", "<e1>", "may", "occur", "early", "in", "C1704945#ent", "<e2>", "."], "h": {"id": "C0277845", "name": "C0277845#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [10, 11]}}
{"token": ["A", "fourth", "MR", "examination", "performed", ",", "in", "conjunction", "with", "both", "oral", "administration", "C0022957#ent", "<e1>", "and", "rectal", "application", "of", "C0012772#ent", "<e2>", "."], "h": {"id": "C0022957", "name": "C0022957#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0012772", "name": "C0012772#ent", "pos": [18, 19]}}
{"token": ["Somato-Sensory", "Evoked", "Potential", "SSEP", ")", "and", "Peripheral", "Nerve", "Conduction", "PNC", ")", "studies", "were", "performed", "in", "twenty", "patients", "with", "C0700502#ent", "<e1>", "elucidate", "the", "changes", "of", "central", "and", "peripheral", "nervous", "systems", "C0020676#ent", "<e2>", "state", "and", "the", "effects", "of", "thyroxine", "replacement"], "h": {"id": "C0700502", "name": "C0700502#ent", "pos": [18, 19]}, "relation": "has_nichd_parent", "t": {"id": "C0020676", "name": "C0020676#ent", "pos": [29, 30]}}
{"token": ["Our", "findings", "demonstrate", "that", "CT", "caused", "the", "inhibition", "of", "C0907533#ent", "<e1>", "MAP", "kinase", "phosphorylation", "in", "a", "C0058980#ent", "<e2>", "in", "DU145", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0058980", "name": "C0058980#ent", "pos": [16, 17]}}
{"token": ["C0276447#ent", "<e1>", "the", "lower", "airways", "now", "a", "recognized", "disease", ",", "associated", "with", "C0006274#ent", "<e2>", "and", "asthma", "."], "h": {"id": "C0276447", "name": "C0276447#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006274", "name": "C0006274#ent", "pos": [12, 13]}}
{"token": ["Caspase-3", "activation", "and", "cleavage", "of", "C1436356#ent", "<e1>", "PARP", ")", "occurred", "at", "a", "late", "stage", "but", "the", "C1516312#ent", "<e2>", "zVAD-fmk", "did", "not", "block", "TTA-induced", "apoptosis", "."], "h": {"id": "C1436356", "name": "C1436356#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1516312", "name": "C1516312#ent", "pos": [16, 17]}}
{"token": ["mutant", "C1704975#ent", "<e1>", "-", "1", "exhibits", "a", "pale", "phenotype", "compared", "to", "the", "C1883559#ent", "<e2>"], "h": {"id": "C1704975", "name": "C1704975#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1883559", "name": "C1883559#ent", "pos": [12, 13]}}
{"token": ["Grafted", "cells", "were", "not", "C0178601#ent", "<e1>", ",", "but", "they", "expressed", "glial", "cell", "line-derived", "neurotrophic", "factor", "C1333669#ent", "<e2>", ")", "and", "transforming", "growth", "factor-beta(1", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1333669", "name": "C1333669#ent", "pos": [15, 16]}}
{"token": ["The", "formulations", "were", "a", "combination", "glibenclamide/metformin", "tablet", "(", "C0939344#ent", "<e1>", ";", "controlled-particle-size", "glibenclamide", "and", "metformin", ")", "versus", "C0017628#ent", "<e2>", "(", "Micronase", ")", "and", "metformin", "(", "Glucophage", ")", "coadministered", "separately", "."], "h": {"id": "C0939344", "name": "C0939344#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017628", "name": "C0017628#ent", "pos": [17, 18]}}
{"token": ["These", "biopsies", "showed", "a", "lobular", "panniculitis", "C1280433#ent", "<e1>", "that", "more", "closely", "resembled", "C0030327#ent", "<e2>", "previous", "reports", "of", "localized", "panniculitis", "at", "glatiramer", "acetate", "injection", "sites"], "h": {"id": "C1280433", "name": "C1280433#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030327", "name": "C0030327#ent", "pos": [12, 13]}}
{"token": ["C0377401#ent", "<e1>", "(", "VNB", ")", "is", "one", "of", "new", "semi-synthesized", "vinka", "C0949738#ent", "<e2>", "developed", "in", "France", ",", "of", "which", "anti-tumor", "activity", "susceptible", "mainly", "to", "non-small", "cell", "lung", "cancer", "breast", "cancer"], "h": {"id": "C0377401", "name": "C0377401#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0949738", "name": "C0949738#ent", "pos": [11, 12]}}
{"token": ["Congenital", "abnormalities", "include", "holoprosencephaly", ",", "hydranencephaly", ",", "agenesis", "of", "the", "corpus", "callosum", "interhemispheric", "cyst", "C4082173#ent", "<e1>", ",", "schizencephaly", ",", "and", "C0078981#ent", "<e2>"], "h": {"id": "C4082173", "name": "C4082173#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0078981", "name": "C0078981#ent", "pos": [20, 21]}}
{"token": ["166", "patients", "receiving", "moderately", "emetogenic", "chemotherapy", "entered", "into", "a", "randomised", "prospective", "study", "which", "the", "efficacy", "of", "single", "dose", "ondansetron", "8", "mg", ",", "tropisetron", "5", "mg", "C0061863#ent", "<e1>", "in", "the", "prophylaxis", "of", "C0232597#ent", "<e2>", "evaluated", "."], "h": {"id": "C0061863", "name": "C0061863#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0232597", "name": "C0232597#ent", "pos": [31, 32]}}
{"token": ["The", "C0015625#ent", "<e1>", "patients", "received", "134.0", "+", "/-", "15.3", "microg/kg", "C0015846#ent", "<e2>", "citrate", "and", "the", "CA", "patients", "15.7", "+", "/-", "7.4", "microg/kg", "C0015846#ent", "<e2>", "during", "the", "surgery", "."], "h": {"id": "C0015625", "name": "C0015625#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0015846", "name": "C0015846#ent", "pos": [10, 11]}}
{"token": ["7,8-Dihydroxyflavone", ",", "an", "antioxidant", "and", "C0033613#ent", "<e1>", "in", "vitro", "decreased", "serum", "glutamate-pyruvate", "transaminase", "levels", "C0001899#ent", "<e2>", ")", "in", "a", "dose-related", "manner", ",", "and", "at", "200", "mg/kg", "inhibited", "bromobenzene-induced", "glutathione", "depletion", "in", "liver", "."], "h": {"id": "C0033613", "name": "C0033613#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001899", "name": "C0001899#ent", "pos": [14, 15]}}
{"token": ["Since", "myosin", "II", "regulated", "by", "both", "the", "myosin", "light", "chain", "kinase", "C1334539#ent", "<e1>", ")", "and", ",", "directly", "or", "indirectly", ",", "the", "C1738267#ent", "<e2>", "ROCK", ")", ",", "we", "examined", "the", "effects", "of", "inhibitors", "against", "these", "kinases", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1738267", "name": "C1738267#ent", "pos": [21, 22]}}
{"token": ["Samples", "of", "P", "and", "BC", "were", "also", "precipitated", "with", "C0600203#ent", "<e1>", "centrifuged", "and", "soluble", "(", "C1705295#ent", "<e2>", ")", "and", "insoluble", "fractions", "(", "IF", ")", "isolated", "."], "h": {"id": "C0600203", "name": "C0600203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705295", "name": "C1705295#ent", "pos": [15, 16]}}
{"token": ["Consistent", "with", "direct", "role", "for", "Hh", "signaling", "C0032002#ent", "<e1>", "patterning", ",", "overexpression", "of", "C0672708#ent", "<e2>", "results", "in", "expanded", "adenohypophyseal", "expression", "lim3", ",", "expansion", "of", "nk2.2", "into", "the", "posterior", "adenohypophysis", "and", "an", "increase", "in", "Prolactin-", "and", "Somatolactin-secreting", "cells"], "h": {"id": "C0032002", "name": "C0032002#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0672708", "name": "C0672708#ent", "pos": [13, 14]}}
{"token": ["This", "study", "shows", "that", "the", "mutation", "in", "subunit", "AddB", "hardly", "affected", "the", "ATPase", ",", "C0920283#ent", "<e1>", ",", "and", "exonuclease", "activities", "the", "C0913945#ent", "<e2>"], "h": {"id": "C0920283", "name": "C0920283#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0913945", "name": "C0913945#ent", "pos": [21, 22]}}
{"token": ["Early", "in", "the", "course", "of", "C4284744#ent", "<e1>", ",", "the", "risk", "of", "progression", "to", "C0023890#ent", "<e2>", "concerns", "1/18", "VHB", ",", "3/4", "VHD", ",", "8/47", "C4284744#ent", "<e1>", "NA", "NB", "."], "h": {"id": "C4284744", "name": "C4284744#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [13, 14]}}
{"token": ["LY-83583", "(", "100", "microM", ")", "inhibited", "the", "release", "of", "both", "C2986618#ent", "<e1>", "and", "MPO", "after", "stimulation", "with", "C1705725#ent", "<e2>", "or", "A-23187", "."], "h": {"id": "C2986618", "name": "C2986618#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705725", "name": "C1705725#ent", "pos": [17, 18]}}
{"token": ["C1421451#ent", "<e1>", "was", "positive", "in", "all", "tumors", ",", "C1425409#ent", "<e2>", "in", "12", ",", "cytokeratin", "in", "8", ",", "desmin", "in", "2", "and", "myoglobin", "in", "one", "."], "h": {"id": "C1421451", "name": "C1421451#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1425409", "name": "C1425409#ent", "pos": [8, 9]}}
{"token": ["Among", "the", "14", "patients", "treated", "with", "C0004057#ent", "<e1>", "alone", ",", "large", "coronary", "aneurysms", "noted", "in", "four", ",", "moderate", "C0751003#ent", "<e2>", "in", "three", "and", "transient", "C0751003#ent", "<e2>", "in", "one", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0751003", "name": "C0751003#ent", "pos": [18, 19]}}
{"token": ["In", "Poland", "the", "high", "prevalence", "of", "the", "risk", "factors", "C0162819#ent", "<e1>", "frequent", "coexistence", "of", "C0018799#ent", "<e2>", "among", "the", "main", "causes", "of", "the", "high", "death", "rate", "in", "stroke", "."], "h": {"id": "C0162819", "name": "C0162819#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [14, 15]}}
{"token": ["It", "is", "concluded", "that", "Ca2", "+", "released", "from", "stores", "accounts", "for", "C3538854#ent", "<e1>", "and", "most", "of", "the", "'", "C1422492#ent", "<e2>", "calcium", "'", "."], "h": {"id": "C3538854", "name": "C3538854#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1422492", "name": "C1422492#ent", "pos": [18, 19]}}
{"token": ["In", "C0338451#ent", "<e1>", "patients", ",", "we", "identified", "dose", "dependent", "effects", "of", "C1412481#ent", "<e2>", "epsilon4", "on", "the", "Behave-AD", "total", "and", "cluster", "aggressiveness", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1412481", "name": "C1412481#ent", "pos": [11, 12]}}
{"token": ["The", "pathophysiologic", "mechanism", "underlying", "the", "association", "between", "C1412332#ent", "<e1>", "excretion", "and", "C0007820#ent", "<e2>", "is", "not", "fully", "defined", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [11, 12]}}
{"token": ["Furthermore", ",", "exposure", "of", "cultured", "motor", "neurons", "oxidized", "WT", "C1420306#ent", "<e1>", "caused", "dose-dependent", "cell", "death", "mutant", "C0010461#ent", "<e2>"], "h": {"id": "C1420306", "name": "C1420306#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0010461", "name": "C0010461#ent", "pos": [16, 17]}}
{"token": ["The", "recently", "cloned", "PMP22", "gene", "the", "rat", "variant", "of", "the", "murine", "growth", "C1333659#ent", "<e1>", ",", "encodes", "a", "new", "22", "C1705240#ent", "<e2>", "integral", "membrane", "glycoprotein", "peripheral", "myelin"], "h": {"id": "C1333659", "name": "C1333659#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705240", "name": "C1705240#ent", "pos": [19, 20]}}
{"token": ["This", "phenotype", "is", "similar", "to", "human", "conjugated", "hyperbilirubinemia", "in", "Dubin-Johnson", "syndrome", "which", "is", "caused", "by", "mutations", "in", "the", "C0763572#ent", "<e1>", "MRP2", ",", "gene", "symbol", "ABCC2", ",", "although", "this", "C1848862#ent", "<e2>", "is", "not", "associated", "with", "overt", "liver", "injury"], "h": {"id": "C0763572", "name": "C0763572#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [28, 29]}}
{"token": ["Administration", "of", "C0207800#ent", "<e1>", ",", "a", "selective", "inhibitor", "of", "C1421249#ent", "<e2>", "attenuated", "stimulation", "of", "tyrosine", "phosphorylation", "hippocampal", "degeneration", "after", "ischemia", "or", "kainic", "acid", "injection", "."], "h": {"id": "C0207800", "name": "C0207800#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [9, 10]}}
{"token": ["We", "studied", "the", "association", "of", "the", "VDR", "polymorphisms", "and", "their", "haplotypes", "with", "patients", "'", "C1826421#ent", "<e1>", "and", "also", "SNPs", "and", "haplotypes", "association", "with", "C0339143#ent", "<e2>"], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0339143", "name": "C0339143#ent", "pos": [23, 24]}}
{"token": ["The", "cleft-type", "cyclophanes", "(", "C3890221#ent", "<e1>", ",", "DNCn", "and", "C1419893#ent", "<e2>", ")", "were", "found", "to", "strongly", "inhibit", "macroscopic", "currents", "heteromeric", "NMDA", "receptors", "NR1/NR2", ")", "but", "not", "AMPA", "receptors", "expressed", "in", "Xenopus", "oocytes", "voltage-clamp", "recording", "."], "h": {"id": "C3890221", "name": "C3890221#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1419893", "name": "C1419893#ent", "pos": [9, 10]}}
{"token": ["To", "report", "a", "clinical", "case", "a", "21-year", "old", "male", "with", "a", "severe", "C0000833#ent", "<e1>", "to", "Pseudomonas", "aeruginosa", "refractory", "to", "intensive", "treatment", "topical", "C0008809#ent", "<e2>", "."], "h": {"id": "C0000833", "name": "C0000833#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [22, 23]}}
{"token": ["The", "newer", "C3542473#ent", "<e1>", "are", "potent", "SAC", "C0991617#ent", "<e2>", "to", "deal", "with", "enterobacteria", "."], "h": {"id": "C3542473", "name": "C3542473#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [7, 8]}}
{"token": ["The", "effects", "of", "C0025677#ent", "<e1>", "(", "MTX", ")", "on", "the", "expression", "of", "selected", "C0907533#ent", "<e2>", "cytochrome", "P450", "CYP", ")", "isozymes", "in", "the", "liver", "of", "male", "rats", "at", "the", "catalytic", "activity", "mRNA", "levels", "examined", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [13, 14]}}
{"token": ["Another", "possibility", "is", "the", "use", "of", "C0025677#ent", "<e1>", "in", "patients", "with", "refractory", "ulcerative", "colitis", "C0010346#ent", "<e2>"], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [14, 15]}}
{"token": ["C0023067#ent", "<e1>", "secondary", "to", "gastric", "acid", "reflux", "a", "prevalent", ",", "yet", "incompletely", "understood", ",", "C3898066#ent", "<e2>"], "h": {"id": "C0023067", "name": "C0023067#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C3898066", "name": "C3898066#ent", "pos": [14, 15]}}
{"token": ["C0009186#ent", "<e1>", "is", "an", "endemic", "C0026946#ent", "<e2>", "the", "southwestern", "United", "States", "causes", "considerable", "morbidity", "and", "mortality", "in", "transplant", "recipients", ",", "often", "as", "the", "result", "of", "reactivated", "infection", "."], "h": {"id": "C0009186", "name": "C0009186#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [5, 6]}}
{"token": ["C0085019#ent", "<e1>", "XAA", ")", "and", "its", "5,6-dimethyl", "derivative", "(", "C2930490#ent", "<e2>", ")", "were", "synthesised", "during", "a", "search", "for", "better", "analogues", "of", "FAA", "."], "h": {"id": "C0085019", "name": "C0085019#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2930490", "name": "C2930490#ent", "pos": [9, 10]}}
{"token": ["Although", "the", "process", "of", "clonal", "evolution", "ATL", "cells", "may", "involve", "multiple", "steps", "ATL", "cells", "from", "half", "of", "the", "ATL", "cases", "still", "retain", "the", "ability", "to", "express", "C0079559#ent", "<e1>", "a", "key", "molecule", "of", "C0079556#ent", "<e2>"], "h": {"id": "C0079559", "name": "C0079559#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0079556", "name": "C0079556#ent", "pos": [32, 33]}}
{"token": ["The", "aim", "of", "this", "study", "is", "to", "assess", "the", "serum", "concentrations", "of", "these", "cytokines", "in", "myeloproliferative", "disorders", "MPD", ")", "with", "C3277671#ent", "<e1>", "and", "in", "rheumatoid", "arthritis", "RA", ")", "with", "marked", "C0836924#ent", "<e2>"], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [20, 21]}, "relation": "has_manifestation", "t": {"id": "C0836924", "name": "C0836924#ent", "pos": [30, 31]}}
{"token": ["Platelet", "phospholipids", "analyzed", "in", "patients", "with", "C3277671#ent", "<e1>", "due", "to", "myeloproliferative", "disorders", "C0836924#ent", "<e2>"], "h": {"id": "C3277671", "name": "C3277671#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0836924", "name": "C0836924#ent", "pos": [12, 13]}}
{"token": ["C1705002#ent", "<e1>", ",", "AtERF2", ",", "and", "AtERF5", "functioned", "as", "activators", "of", "C4084890#ent", "<e2>", "box-dependent", "transcription", "Arabidopsis", "leaves", "."], "h": {"id": "C1705002", "name": "C1705002#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C4084890", "name": "C4084890#ent", "pos": [11, 12]}}
{"token": ["The", "projections", "to", "the", "RCA", "and", "POA", "are", "present", "by", "C1335796#ent", "<e1>", "and", "reach", "the", "adult", "pattern", "by", "C1704968#ent", "<e2>", "."], "h": {"id": "C1335796", "name": "C1335796#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704968", "name": "C1704968#ent", "pos": [18, 19]}}
{"token": ["A", "58-year-old", "woman", "who", "had", "been", "treated", "with", "oxygen", "therapy", "C0264492#ent", "<e1>", "by", "interstitial", "pneumonia", "admitted", "to", "Metropolitan", "Ohtsuka", "Hospital", "because", "of", "C1291077#ent", "<e2>"], "h": {"id": "C0264492", "name": "C0264492#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1291077", "name": "C1291077#ent", "pos": [22, 23]}}
{"token": ["These", "exosomes", "are", "similar", "to", "C1413852#ent", "<e1>", "derived", "exosomes", "as", "they", "express", "MHC", "class", "I", "II", ",", "C1334074#ent", "<e2>", ",", "CD63", "and", "the", "co-stimulatory", "molecule", "CD86", "."], "h": {"id": "C1413852", "name": "C1413852#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334074", "name": "C1334074#ent", "pos": [17, 18]}}
{"token": ["In", "motoneurons", "receiving", "C0242901#ent", "<e1>", "and", "GABAergic", "innervation", "from", "spinal", "interneurons", "C1423507#ent", "<e2>", ",", "GlyRalpha/beta", ",", "and", "GABA(A)Rbeta", "formed", "mosaics", "at", "synaptic", "loci", "."], "h": {"id": "C0242901", "name": "C0242901#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1423507", "name": "C1423507#ent", "pos": [11, 12]}}
{"token": ["Is", "this", "elaboration", "the", "analysis", "of", "a", "return", "to", "C0030193#ent", "<e1>", "work", "by", "76", "consecutive", "suffering", "from", "back", "pain", "C0027796#ent", "<e2>", "to", "the", "lumbar", "discopathy", "after", "rehabilitation", "has", "been", "presented", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0027796", "name": "C0027796#ent", "pos": [19, 20]}}
{"token": ["To", "better", "understand", "the", "phylogeny", "and", "pharmacology", "of", "NPY", "in", "C1334982#ent", "<e1>", "we", "have", "cloned", "and", "expressed", "the", "NPY", "Y1", "Y2", "and", "C1417818#ent", "<e2>", "subtypes", "from", "the", "Rhesus", "monkey"], "h": {"id": "C1334982", "name": "C1334982#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417818", "name": "C1417818#ent", "pos": [22, 23]}}
{"token": ["Embolectomy", "under", "local", "anesthesia", "advocated", "in", "all", "cases", "after", "prompt", "correction", "of", "fluid", "and", "electrolyte", "imbalance", "and", "stabilization", "of", "the", "underlying", "C0018824#ent", "<e1>", "except", "in", "patients", "with", "frank", "gangrene", "irreversible", "C0026837#ent", "<e2>", "."], "h": {"id": "C0018824", "name": "C0018824#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [30, 31]}}
{"token": ["Results", "from", "real", "time", "binding", "experiments", "evidence", "for", "direct", "interaction", "of", "Ca(2+)/calmodulin", "with", "HDAC5", "inhibiting", "C1417099#ent", "<e1>", "association", "with", "this", "C0014442#ent", "<e2>", "."], "h": {"id": "C1417099", "name": "C1417099#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [20, 21]}}
{"token": ["Iron", "mobilization", "to", "the", "metabolism", "of", "ethanol", "to", "acetaldehyde", "by", "C3659502#ent", "<e1>", "increased", "100", "%", "by", "the", "addition", "of", "C1412433#ent", "<e2>"], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412433", "name": "C1412433#ent", "pos": [19, 20]}}
{"token": ["When", "transfected", "into", "BSC-1", "cell", "monolayers", ",", "only", "the", "combination", "of", "E", "and", "C0017428#ent", "<e1>", "a", "lytic", "infection", "followed", "by", "the", "synthesis", "of", "C3811848#ent", "<e2>", "SV40", "."], "h": {"id": "C0017428", "name": "C0017428#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3811848", "name": "C3811848#ent", "pos": [23, 24]}}
{"token": ["The", "following", "oculomotor", "problems", "were", "seen", ":", "mystagmus", "in", "11", ",", "ocular", "motor", "apraxia", "six", ",", "isolated", "C0005745#ent", "<e1>", "in", "two", ",", "and", "C0152222#ent", "<e2>", "three", "."], "h": {"id": "C0005745", "name": "C0005745#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0152222", "name": "C0152222#ent", "pos": [23, 24]}}
{"token": ["Downstream", "of", "mitogen-activated", "protein", "kinases", "MAPKs", ")", ",", "three", "structurally", "related", "MAPK-activated", "protein", "kinases", "C1442514#ent", "<e1>", "or", "MKs", ")", "-", "C1452441#ent", "<e2>", ",", "MK3", "and", "MK5", "-", "signal", "to", "diverse", "cellular", "targets"], "h": {"id": "C1442514", "name": "C1442514#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1452441", "name": "C1452441#ent", "pos": [20, 21]}}
{"token": ["The", "clinical", "presentations", "C0155686#ent", "<e1>", "variable", ",", "ranging", "from", "an", "initial", "C0231218#ent", "<e2>", "acute", "progressive", "heart", "failure", ",", "and", "at", "times", ",", "even", "death", "."], "h": {"id": "C0155686", "name": "C0155686#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0231218", "name": "C0231218#ent", "pos": [11, 12]}}
{"token": ["A", "novel", "potential", "regulatory", "pathway", "brown", "adipose", "tissue", "C1412726#ent", "<e1>", ")", "thermogenesis", "was", "recently", "recognized", "after", "identifying", "retinoic", "acid", "C0003873#ent", "<e2>", ")", "as", "a", "transcriptional", "activator", "the", "uncoupling", "protein", "UCP", ")", "gene", "."], "h": {"id": "C1412726", "name": "C1412726#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [19, 20]}}
{"token": ["Of", "primary", "importance", "is", "the", "inhibiting", "effect", "of", "TNF-alpha", "on", "PTKase", ",", "since", "this", "induces", "insulin", "resistance", "C0011860#ent", "<e1>", "and", "carcinoma", ",", "and", "C0085536#ent", "<e2>", ",", "which", "inhibits", "MHC", "class", "I", "molecule", "expression", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085536", "name": "C0085536#ent", "pos": [23, 24]}}
{"token": ["These", "results", "suggest", "that", "C1415700#ent", "<e1>", "may", "be", "the", "first", "C0036734#ent", "<e2>", "expressed", "during", "mammalian", "development", ",", "making", "its", "ability", "to", "autoactivate", "critical", "to", "its", "function", "."], "h": {"id": "C1415700", "name": "C1415700#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0036734", "name": "C0036734#ent", "pos": [10, 11]}}
{"token": ["Whereas", "clobenpropit", "and", "C0760067#ent", "<e1>", "were", "consistently", "antagonists", ",", "GT-2331", ",", "proxyfan", ",", "and", "C0173792#ent", "<e2>", "exhibited", "differential", "activity"], "h": {"id": "C0760067", "name": "C0760067#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0173792", "name": "C0173792#ent", "pos": [14, 15]}}
{"token": ["Scleroderma", "in", "plaque", "must", "be", "differentiated", "from", "hypodermitis", "sclerotisans", ",", "panatrophy", "and", "localized", "C0023787#ent", "<e1>", ",", "hypodermitis", "after", "vitamin", "K", "injection", ",", "basal", "cell", "carcinoma", "C0027538#ent", "<e2>", "vitiligo", ",", "chronic", "radiodermatitis", "cutaneous", "lymphatic", "invasion"], "h": {"id": "C0023787", "name": "C0023787#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0027538", "name": "C0027538#ent", "pos": [25, 26]}}
{"token": ["Apiaceous", "vegetable", "decreased", "C0769262#ent", "<e1>", "in", "the", "C1738886#ent", "<e2>", "+", "men", "(", "P", "=", "0.03", ")", "."], "h": {"id": "C0769262", "name": "C0769262#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1738886", "name": "C1738886#ent", "pos": [7, 8]}}
{"token": ["Liver", "cytosol", "mice", "fed", "on", "a", "normal", "diet", "C0769262#ent", "<e1>", "GST", ")", "subunits", "of", "Mr", "25,800", ",", "Mu-class", "C1738886#ent", "<e2>", "Mr", "26,400", "and", "Pi-class", "C1738886#ent", "<e2>", "Mr", "24,800", "."], "h": {"id": "C0769262", "name": "C0769262#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1738886", "name": "C1738886#ent", "pos": [18, 19]}}
{"token": ["25-Hydroxycholesterol", "(", "25HC", ")", "in", "particular", "has", "been", "demonstrated", "to", "regulate", "cholesterol", "homeostasis", "C1418188#ent", "<e1>", "oxysterol-related", "proteins", "the", "sterol", "regulatory", "element", "binding", "protein", "and", "the", "rate-limiting", "enzyme", "of", "cholesterol", "biosynthesis", "C0063164#ent", "<e2>"], "h": {"id": "C1418188", "name": "C1418188#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0063164", "name": "C0063164#ent", "pos": [30, 31]}}
{"token": ["C0717758#ent", "<e1>", "is", "the", "first", "anticytokine", "drug", "approved", "to", "treat", "C0003873#ent", "<e2>"], "h": {"id": "C0717758", "name": "C0717758#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [10, 11]}}
{"token": ["We", "evaluated", "the", "factors", "that", "influence", "the", "use", "of", "complementary", "and", "alternative", "medicine", "(", "C1861821#ent", "<e1>", ")", "by", "people", "with", "C0014547#ent", "<e2>", "."], "h": {"id": "C1861821", "name": "C1861821#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [20, 21]}}
{"token": ["As", "expected", ",", "C1258073#ent", "<e1>", "substantially", "impaired", "in", "cells", "deficient", "for", "the", "NHEJ", "components", "C1823878#ent", "<e2>", ",", "XRCC4", ",", "and", "DNA-PKcs", "."], "h": {"id": "C1258073", "name": "C1258073#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1823878", "name": "C1823878#ent", "pos": [14, 15]}}
{"token": ["These", "data", "implicate", "C0006784#ent", "<e1>", "in", "the", "pathogenesis", "of", "C0442874#ent", "<e2>", "and", "demonstrate", "that", "AK295", "can", "prevent", "axonal", "degeneration", "clinical", "neuropathy", "mice", "."], "h": {"id": "C0006784", "name": "C0006784#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [9, 10]}}
{"token": ["Disorders", "in", "the", "DNA", "repair", "the", "human", "lymphocytes", "isolated", "from", "patients", "with", "C1414542#ent", "<e1>", "homocystinuria", ",", "schizophrenia", ",", "and", "C0018099#ent", "<e2>", "have", "been", "found", "."], "h": {"id": "C1414542", "name": "C1414542#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0018099", "name": "C0018099#ent", "pos": [19, 20]}}
{"token": ["Acetylcholine-induced", "hypothalamic", "C1705056#ent", "<e1>", "activity", "was", "also", "antagonized", "by", "C0354872#ent", "<e2>", "but", "not", "by", "methysergide.5", "."], "h": {"id": "C1705056", "name": "C1705056#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0354872", "name": "C0354872#ent", "pos": [9, 10]}}
{"token": ["Etoricoxib", "is", "a", "cyclo-oxygenase", "(COX)-2-selective", "NSAID", "with", "a", "higher", "COX-1", "to", "COX-2", "selectivity", "ratio", "than", "the", "other", "COX-2-selective", "C0003211#ent", "<e1>", "rofecoxib", ",", "valdecoxib", "or", "C0538927#ent", "<e2>", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [18, 19]}, "relation": "structural_class_of", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [24, 25]}}
{"token": ["For", "women", "with", "C0029458#ent", "<e1>", "therapy", "with", "hormone", "replacement", "bisphosphonates", "(", "alendronate", "sodium", "C0166025#ent", "<e2>", ",", "raloxifene", "hydrochloride", "or", "calcitonin", "should", "be", "considered", "."], "h": {"id": "C0029458", "name": "C0029458#ent", "pos": [3, 4]}, "relation": "may_be_prevented_by", "t": {"id": "C0166025", "name": "C0166025#ent", "pos": [13, 14]}}
{"token": ["Like", "MedB-1", ",", "Karpas1106P", "harbors", "gains", "of", "the", "C1334291#ent", "<e1>", "chromosomal", "region", "9p24", "elevated", "levels", "of", "C1527617#ent", "<e2>", "mRNA", "."], "h": {"id": "C1334291", "name": "C1334291#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1527617", "name": "C1527617#ent", "pos": [16, 17]}}
{"token": ["Muscle", "wasting", "seen", "in", "both", "groups", "of", "mice", "4", "days", "after", "a", "single", "C0067099#ent", "<e1>", "injection", ",", "and", "the", "C0013227#ent", "<e2>", "further", "increased", "the", "loss", "of", "muscle", "proteins", "apparent", "in", "tumor-bearing", "animals", "."], "h": {"id": "C0067099", "name": "C0067099#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [19, 20]}}
{"token": ["Six", "patients", "had", "spinal", "cord", "lesions", "one", "had", "a", "brain", "injury", "one", "had", "C0007789#ent", "<e1>", "one", "had", "multiple", "sclerosis", "and", "one", "had", "progressive", "C0037928#ent", "<e2>", "."], "h": {"id": "C0007789", "name": "C0007789#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0037928", "name": "C0037928#ent", "pos": [23, 24]}}
{"token": ["After", "a", "6-week", "open-label", ",", "fixed-flexible", "dosing", "schedule", ",", "response", "to", "C0031008#ent", "<e1>", "on", "standard", "C0040517#ent", "<e2>", "severity", "outcome", "measures", "assessed", "."], "h": {"id": "C0031008", "name": "C0031008#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [15, 16]}}
{"token": ["However", ",", "C1522507#ent", "<e1>", "can", "also", "be", "proteolytically", "cleaved", "from", "its", "C1417326#ent", "<e2>", "release", "a", "freely", "diffusible", "form", "."], "h": {"id": "C1522507", "name": "C1522507#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1417326", "name": "C1417326#ent", "pos": [11, 12]}}
{"token": ["Daily", "inhalation", "by", "mice", "of", "an", "environmental", "irritant", "H2SO4", ")", "followed", "by", "consequent", "respiratory", "immunization", "with", "a", "particulate", "antigen", "sheep", "red", "blood", "cells", "C1705087#ent", "<e1>", ")", "induced", "severe", "C0206061#ent", "<e2>"], "h": {"id": "C1705087", "name": "C1705087#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0206061", "name": "C0206061#ent", "pos": [28, 29]}}
{"token": ["Lymphoid", "enhancer", "cell", "factor", "proteins", "(", "LEF/TCFs", ")", "mediate", "Wnt", "signals", "the", "nucleus", "by", "recruiting", "C1332803#ent", "<e1>", "and", "its", "C3275267#ent", "<e2>", "to", "Wnt", "response", "elements", "WREs", ")", "of", "target", "genes", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3275267", "name": "C3275267#ent", "pos": [19, 20]}}
{"token": ["In", "contrast", ",", "F-IHA", "patients", "showed", "increases", "in", "the", "above", "mineralocorticoids", "except", "18-OH-B.", "Following", "DA", "infusion", "in", "normal", "subjects", "basal", "plasma", "C0162309#ent", "<e1>", "secretion", "nor", "the", "responsivenesses", "to", "C3540820#ent", "<e2>", "were", "modified", "."], "h": {"id": "C0162309", "name": "C0162309#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C3540820", "name": "C3540820#ent", "pos": [28, 29]}}
{"token": ["Early", "patterning", "of", "the", "endoderm", "as", "a", "prerequisite", "for", "C0771711#ent", "<e1>", "specification", "involves", "C0022265#ent", "<e2>", "RA", ")", "as", "a", "critical", "signalling", "molecule", "gastrula", "stage", "Xenopus", "embryos"], "h": {"id": "C0771711", "name": "C0771711#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022265", "name": "C0022265#ent", "pos": [13, 14]}}
{"token": ["The", "Fas-based", "mechanism", "involves", "the", "C0040663#ent", "<e1>", "Fas", "and", "its", "ligand", "(", "C1539478#ent", "<e2>", ")", "."], "h": {"id": "C0040663", "name": "C0040663#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539478", "name": "C1539478#ent", "pos": [12, 13]}}
{"token": ["Both", "in", "vitro", "in", "vivo", "results", "support", "the", "hypothesis", "that", "C1258847#ent", "<e1>", "activation", "with", "subsequent", "synthesis", "of", "regulatory", "factors", "as", "C1522428#ent", "<e2>", "a", "significant", "role", "in", "determining", "the", "host", "response", "to", "biomedical", "polymer", "implants", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1522428", "name": "C1522428#ent", "pos": [20, 21]}}
{"token": ["2", ")", "To", "review", ",", "in", "a", "retrospective", "study", "for", "comparison", ",", "the", "natural", "evolution", "neovascular", "C0017921#ent", "<e1>", "eyes", "with", "C1538023#ent", "<e2>", "."], "h": {"id": "C0017921", "name": "C0017921#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1538023", "name": "C1538023#ent", "pos": [20, 21]}}
{"token": ["Intra-articular", "pressure", "measured", "in", "94", "hips", "in", "81", "children", "with", "Perthes'", "disease", "various", "forms", "of", "C1739148#ent", "<e1>", "of", "the", "C1335638#ent", "<e2>", "."], "h": {"id": "C1739148", "name": "C1739148#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1335638", "name": "C1335638#ent", "pos": [19, 20]}}
{"token": ["SF-1", "was", "acetylated", "in", "vitro", "in", "vivo", "C1333336#ent", "<e1>", "at", "the", "KQQKK", "motif", "in", "the", "C3813144#ent", "<e2>", "(", "Fushi-tarazu", "factor", "1", "box", "adjacent", "to", "its", "DNA-binding", "domain"], "h": {"id": "C1333336", "name": "C1333336#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3813144", "name": "C3813144#ent", "pos": [15, 16]}}
{"token": ["Recent", "studies", "identified", "that", "the", "C0017337#ent", "<e1>", "coding", "for", "human", "beta-defensin", "2", "C1539243#ent", "<e2>", ")", ",", "human", "beta-defensin", "3", "DEFB103", ")", "and", "human", "beta-defensin", "4", "DEFB104", ")", "showed", "variation", "in", "copy", "numbers"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1539243", "name": "C1539243#ent", "pos": [12, 13]}}
{"token": ["C0056539#ent", "<e1>", "and", "the", "mammalian", "C0030940#ent", "<e2>", "cleaved", "cystatin-derived", "substrates", "at", "the", "same", "site", ",", "but", "their", "specificities", "differed", "significantly", "."], "h": {"id": "C0056539", "name": "C0056539#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030940", "name": "C0030940#ent", "pos": [5, 6]}}
{"token": ["Juvenile", "dermatomyositis", "JDM", ")", "is", "a", "C0004364#ent", "<e1>", "at", "times", "resembles", "C0018133#ent", "<e2>"], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0018133", "name": "C0018133#ent", "pos": [11, 12]}}
{"token": ["It", "has", "been", "reported", "that", "the", "acquired", "C0021051#ent", "<e1>", "present", "neuropsychiatric", "symptoms", "of", "major", "depressive", "disorders", "adjustment", "disorder", "depressed", "mood", "C0029221#ent", "<e2>", "affective", ",", "delusional", "and", "demented", "features", "."], "h": {"id": "C0021051", "name": "C0021051#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029221", "name": "C0029221#ent", "pos": [20, 21]}}
{"token": ["Blockade", "of", "the", "C0751950#ent", "<e1>", "pancuronium", "did", "not", "induce", "any", "changes", "in", "C1704876#ent", "<e2>", "responses", "to", "CSN", "stimulation", ",", "showing", "that", "these", "responses", "were", "not", "secondary", "to", "changes", "in", "extrafusal", "or", "fusimotor", "activity"], "h": {"id": "C0751950", "name": "C0751950#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704876", "name": "C1704876#ent", "pos": [12, 13]}}
{"token": ["The", "effects", "of", "Ca2", "+", "channel", "blocker", ",", "C0012373#ent", "<e1>", ",", "on", "the", "epileptiform", "activity", "induced", "by", "4-aminopyridine", "(", "C0000477#ent", "<e2>", ")", "were", "studied", "in", "rat", "amygdaloid", "slices", "using", "intracellular", "recording", "techniques"], "h": {"id": "C0012373", "name": "C0012373#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [19, 20]}}
{"token": ["Rac1", "probe", "also", "detected", "the", "66", "-", "68-kDa", "proteins", ",", "suggesting", "the", "possibility", "that", "C0213574#ent", "<e1>", "may", "be", "a", "binding", "protein", "both", "of", "these", "C0029007#ent", "<e2>"], "h": {"id": "C0213574", "name": "C0213574#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0029007", "name": "C0029007#ent", "pos": [24, 25]}}
{"token": ["Here", "we", "show", "that", "SPP", "signals", "through", "the", "EDG-1", "receptor", "the", "C0752348#ent", "<e1>", ",", "leading", "to", "activation", "of", "the", "C1414387#ent", "<e2>", "phosphorylation", "of", "the", "Akt", "substrate", ",", "endothelial", "nitric-oxide", "synthase", "eNOS", ")", "."], "h": {"id": "C0752348", "name": "C0752348#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414387", "name": "C1414387#ent", "pos": [19, 20]}}
{"token": ["Despite", "the", "anabolic", "setting", "by", "the", "transgenic", "animals", "the", "C1416870#ent", "<e1>", "only", "is", "completely", "protected", "against", "C0006625#ent", "<e2>", "."], "h": {"id": "C1416870", "name": "C1416870#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0006625", "name": "C0006625#ent", "pos": [16, 17]}}
{"token": ["C0057856#ent", "<e1>", "analysis", "revealed", "that", "C1823242#ent", "<e2>", "gene", "expression", "remained", "stable", "in", "TSA-treated", "OV1-VCR", "cells", "despite", "a", "localized", "increase", "in", "H4", "acetylation", "the", "promoter", "level"], "h": {"id": "C0057856", "name": "C0057856#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1823242", "name": "C1823242#ent", "pos": [5, 6]}}
{"token": ["Tandem", "mass", "spectrometric", "analysis", "this", "C0030956#ent", "<e1>", "revealed", "that", "C1332661#ent", "<e2>", "was", "labeled", "with", "two", "18O", "atoms", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332661", "name": "C1332661#ent", "pos": [9, 10]}}
{"token": ["The", "large", "C0008733#ent", "<e1>", "compromised", "breathing", "and", "required", "chest", "tube", "drainage", "pleurodesis", ",", "medium", "chain", "triglyceride", "C0724624#ent", "<e2>", ")", "diet", ",", "and", ",", "later", ",", "total", "parenteral", "nutrition", "TPN", ")", "."], "h": {"id": "C0008733", "name": "C0008733#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [16, 17]}}
{"token": ["Five", "classes", "of", "drugs", "accounted", "for", "two", "thirds", "of", "prescriptions", ",", "i.e.", "C0280004#ent", "<e1>", ",", "usual", "antibiotics", ",", "antimalarials", ",", "non-steroid", "anti-inflammatory", "drugs", "and", "C3714649#ent", "<e2>", "."], "h": {"id": "C0280004", "name": "C0280004#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [24, 25]}}
{"token": ["Consistently", ",", "cotransfection", "assays", "demonstrate", "that", "STRA13", "and", "C1419241#ent", "<e1>", "both", "antagonize", "CLOCK", ":", "BMAL1", "dependent", "transactivation", "of", "the", "C1417821#ent", "<e2>", "and", "Dbp", "promoters"], "h": {"id": "C1419241", "name": "C1419241#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417821", "name": "C1417821#ent", "pos": [19, 20]}}
{"token": ["In", "this", "report", ",", "we", "have", "demonstrated", "the", "role", "of", "tyrosine", "phosphorylation", "an", "adaptor", "protein", "3BP2", "C3537390#ent", "<e1>", "also", "known", "as", "C1420022#ent", "<e2>", ")", "in", "T", "cell", "receptor", "activation", "of", "transcription", "factor"], "h": {"id": "C3537390", "name": "C3537390#ent", "pos": [16, 17]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420022", "name": "C1420022#ent", "pos": [21, 22]}}
{"token": ["The", "predicted", "amino", "acid", "sequences", "C0879262#ent", "<e1>", "dsRNA", "showed", "high", "sequence", "homology", "with", "the", "putative", "C0035681#ent", "<e2>", "RNA", "viruses"], "h": {"id": "C0879262", "name": "C0879262#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035681", "name": "C0035681#ent", "pos": [15, 16]}}
{"token": ["Transfer", "from", "insulin", "to", "C1511894#ent", "<e1>", "patients", "with", "neonatal", "C0011849#ent", "<e2>", "due", "to", "Kir6.2", "mutations", "is", "well", "described", ",", "but", "less", "is", "known", "about", "changing", "therapy", "in", "patients", "with", "SUR1", "mutations", "."], "h": {"id": "C1511894", "name": "C1511894#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "our", "data", "suggest", "that", "NaAsO(2", ")", "induces", "chromatin", "opening", "by", "histone", "hyperacetylation", "to", "C1422386#ent", "<e1>", "inhibition", "and", "increase", "of", "the", "mobility", "of", "C2985259#ent", "<e2>"], "h": {"id": "C1422386", "name": "C1422386#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2985259", "name": "C2985259#ent", "pos": [24, 25]}}
{"token": ["C0016860#ent", "<e1>", "which", "is", "claimed", "to", "prevent", "C0238284#ent", "<e2>", "pulmonary", "oedema", "high", "altitude", "tried", "in", "experimental", "animals", "evaluate", "its", "usefulness", "or", "otherwise", "as", "a", "measure", "of", "prophylaxis", "."], "h": {"id": "C0016860", "name": "C0016860#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0238284", "name": "C0238284#ent", "pos": [7, 8]}}
{"token": ["Presents", "a", "case", "of", "an", "atypical", "dermoid", "cyst", "an", "outbreak", "of", "the", "C0010709#ent", "<e1>", "contents", "to", "the", "brain", "ventricles", "origination", "of", "C0865440#ent", "<e2>"], "h": {"id": "C0010709", "name": "C0010709#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0865440", "name": "C0865440#ent", "pos": [21, 22]}}
{"token": ["The", "regulation", "of", "C0538269#ent", "<e1>", "and", "PLO", "by", "C1259877#ent", "<e2>", "related", "oncogenes", "were", "discussed", "."], "h": {"id": "C0538269", "name": "C0538269#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1259877", "name": "C1259877#ent", "pos": [8, 9]}}
{"token": ["Over-expression", "of", "C1420813#ent", "<e1>", "found", "to", "result", "in", "the", "activation", "of", "C0380051#ent", "<e2>", "JNK", ")", "in", "the", "human", "embryonic", "kidney", "cell", "line", "293"], "h": {"id": "C1420813", "name": "C1420813#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [11, 12]}}
{"token": ["Lisinopril", "increased", "rat", "renin", "and", "angiotensinogen", "gene", "expression", "both", "in", "SDH", "and", "C1427067#ent", "<e1>", ",", "but", "it", "did", "not", "influence", "mouse", "C1419338#ent", "<e2>", "expression", "in", "C1427067#ent", "<e1>", "."], "h": {"id": "C1419338", "name": "C1419338#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1427067", "name": "C1427067#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "our", "data", "suggest", "that", "bacterial", "products", "as", "C2697656#ent", "<e1>", "may", "enhance", "cellular", "immune", "responses", "augmenting", "the", "ability", "of", "C1335872#ent", "<e2>", "to", "regulate", "IFN-gamma-inducible", "genes"], "h": {"id": "C2697656", "name": "C2697656#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1335872", "name": "C1335872#ent", "pos": [20, 21]}}
{"token": ["Genetic", "and", "biochemical", "studies", "indicate", "that", "Rad60", "functions", "codependently", "with", "C1822781#ent", "<e1>", "and", "Smc6", ",", "subunits", "of", "an", "C1539322#ent", "<e2>", "(", "structural", "maintenance", "chromosomes", ")", "complex", "required", "for", "recombinational", "repair"], "h": {"id": "C1822781", "name": "C1822781#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [18, 19]}}
{"token": ["The", "turnover", "of", "C0001109#ent", "<e1>", "groups", "of", "C0063566#ent", "<e2>", "PtdIns4P", ")", "and", "phosphatidylinositol", "4,5-bisphosphate", "PtdIns(4,5)P2", "]", "was", "investigated", "in", "human", "erythrocytes", "by", "short-term", "labelling", "with", "[32P]Pi", "."], "h": {"id": "C0001109", "name": "C0001109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0063566", "name": "C0063566#ent", "pos": [7, 8]}}
{"token": ["We", "have", "previously", "demonstrated", "that", "C1419187#ent", "<e1>", "differentially", "modulates", "the", "export", "trafficking", "of", "distinct", "G", "protein-coupled", "receptors", "C3890198#ent", "<e2>", ")", "."], "h": {"id": "C1419187", "name": "C1419187#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3890198", "name": "C3890198#ent", "pos": [17, 18]}}
{"token": ["These", "data", "are", "therefore", "consistent", "with", "induction", "by", "X-irradiation", "of", "a", "positive", "regulator", "of", "telomerase", "activity", "than", "Tnks", "or", "C0086661#ent", "<e1>", "or", "the", "core", "protein", "RNA", "components", "of", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [29, 30]}}
{"token": ["In", "ten", "patients", "with", "C0155127#ent", "<e1>", "FAP", ")", ",", "the", "effects", "of", "atropine", "and", "C0282210#ent", "<e2>", "on", "the", "cardiac", "conduction", "system", "studied", "using", "surface", "electrocardiogram", "ECG", ")", "and", "His", "bundle", "electrograms"], "h": {"id": "C0155127", "name": "C0155127#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0282210", "name": "C0282210#ent", "pos": [14, 15]}}
{"token": ["C0006230#ent", "<e1>", "was", "started", "without", "effect", "and", "a", "new", "treatment", "with", "C0026256#ent", "<e2>", "was", "began", "."], "h": {"id": "C0006230", "name": "C0006230#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026256", "name": "C0026256#ent", "pos": [11, 12]}}
{"token": ["Transforming", "growth", "factor-beta-activated", "kinase", "1", "C1417830#ent", "<e1>", ")", "has", "been", "linked", "to", "C1416395#ent", "<e2>", "tumor", "necrosis", "factor", "receptor", "signaling"], "h": {"id": "C1417830", "name": "C1417830#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1416395", "name": "C1416395#ent", "pos": [12, 13]}}
{"token": ["The", "N-terminal", "SUMO-1", "modification", "site", "is", "conserved", "between", "all", "vertebrate", "C1422622#ent", "<e1>", "is", "found", "in", "all", "members", "of", "the", "C1706138#ent", "<e2>", "family", "of", "protein", "kinases"], "h": {"id": "C1422622", "name": "C1422622#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706138", "name": "C1706138#ent", "pos": [19, 20]}}
{"token": ["The", "pressor", "response", "to", "cocaine", "was", "attenuated", "by", "calcium", "channel", "blockers", "clonidine", ",", "phentolamine", "and", "C1648700#ent", "<e1>", "or", "l-propranolol", ",", "but", "not", "by", "C0033497#ent", "<e2>", "."], "h": {"id": "C1648700", "name": "C1648700#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [23, 24]}}
{"token": ["The", "C1648700#ent", "<e1>", ",", "l-", "and", "d-isomers", "of", "C0033497#ent", "<e2>", "attenuated", "the", "decrease", "in", "ventricular", "fibrillation", "threshold", "and", "the", "increase", "in", "ischaemic", "myocardial", "cyclic", "AMP", "without", "altering", "the", "tissue", "depletion", "of", "ATP", "."], "h": {"id": "C1648700", "name": "C1648700#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0033497", "name": "C0033497#ent", "pos": [8, 9]}}
{"token": ["In", "patients", "with", "prolonged", "or", "complicated", "febrile", "C0036572#ent", "<e1>", "such", "as", "hemiconvulsion-hemiplegia-epilepsy", "syndrome", "C2746066#ent", "<e2>", "be", "included", "in", "the", "differential", "diagnosis", "especially", "in", "children", "with", "concomitant", "macrocephaly", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [7, 8]}, "relation": "manifestation_of", "t": {"id": "C2746066", "name": "C2746066#ent", "pos": [13, 14]}}
{"token": ["C0914069#ent", "<e1>", "Lp-PLA(2)", "is", "an", "C0027203#ent", "<e2>", "that", "is", "produced", "by", "inflammatory", "cells", "macrophages", ",", "T-lymphocytes", "and", "mast", "cells", "and", "hydrolyzes", "oxidized", "phospholipids", "LDL", "."], "h": {"id": "C0914069", "name": "C0914069#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [5, 6]}}
{"token": ["The", "corresponding", "appearance", "of", "the", "C1442804#ent", "<e1>", "expression", "and", "the", "formation", "of", "Purkinje", "cell", "dendritic", "arbors", "that", "C0812307#ent", "<e2>", "involved", "in", "dendrogenesis", "."], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C0812307", "name": "C0812307#ent", "pos": [17, 18]}}
{"token": ["C1439284#ent", "<e1>", "antagonists", "are", "a", "new", "class", "of", "C0035064#ent", "<e2>", "that", ",", "without", "the", "side-effects", "mediated", "by", "kinins", ",", "have", "shown", "their", "efficacy", "in", "the", "treatment", "of", "hypertension", "and", "heart", "failure"], "h": {"id": "C1439284", "name": "C1439284#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [8, 9]}}
{"token": ["Early", "diagnosis", "proper", "management", "could", "prevent", "the", "development", "of", "C0023890#ent", "<e1>", "in", "patients", "with", "galactosemia", ",", "C0016751#ent", "<e2>", "intolerance", ",", "etc", "."], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [9, 10]}, "relation": "manifestation_of", "t": {"id": "C0016751", "name": "C0016751#ent", "pos": [16, 17]}}
{"token": ["Hepatotoxic", "parameters", "studied", "in", "vivo", "serum", "transaminases", "C1420113#ent", "<e1>", "and", "ALT", ")", ",", "serum", "triglyceride", "C1422277#ent", "<e2>", ")", ",", "hepatic", "triglyceride", "HTG", ")", ",", "tumor", "necrosis", "factor", "alpha", "TNF-alpha", ")", ",", "interleukin", "1", "beta", "IL-1beta", ")", ",", "together", "with", "histopathological", "examination"], "h": {"id": "C1420113", "name": "C1420113#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1422277", "name": "C1422277#ent", "pos": [15, 16]}}
{"token": ["Addition", "of", "0.2", "%", "C0039294#ent", "<e1>", "the", "glutaraldehyde", "fixative", "significantly", "reduces", "the", "shrinkage", "of", "C0055816#ent", "<e2>", "microtubules", ",", "but", "has", "no", "effect", "FD", "microtubules", "."], "h": {"id": "C0039294", "name": "C0039294#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0055816", "name": "C0055816#ent", "pos": [14, 15]}}
{"token": ["It", "is", "important", "to", "distinguish", "SS", "(", "an", "idiopathic", "autoimmune", "process", "from", "other", "processes", "including", "hepatitis", "C", "infection", "C0035369#ent", "<e1>", "lymphoma", ",", "autonomic", "neuropathy", "depression", ",", "C0016053#ent", "<e2>", "and", "drug", "side", "effects", "can", "result", "in", "sicca", "symptoms", "."], "h": {"id": "C0035369", "name": "C0035369#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0016053", "name": "C0016053#ent", "pos": [26, 27]}}
{"token": ["Laminin-5", "gamma2", "or", "C2698300#ent", "<e1>", "subunit-reactive", "budding", "carcinoma", "cells", "expressed", "cytokeratins", "but", "not", "C1421451#ent", "<e2>", ";", "they", "did", "not", "proliferate", "and", "were", "not", "apoptotic", "."], "h": {"id": "C2698300", "name": "C2698300#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1421451", "name": "C1421451#ent", "pos": [13, 14]}}
{"token": ["The", "mean", "concentration", "of", "C1417154#ent", "<e1>", "in", "synovial", "fluid", "significantly", "higher", "in", "OA", "than", "in", "C0003873#ent", "<e2>", "."], "h": {"id": "C1417154", "name": "C1417154#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [15, 16]}}
{"token": ["C0080138#ent", "<e1>", "attenuated", "morphine", "induction", "of", "C0162508#ent", "<e2>", "striatum", ",", "suggesting", "that", "c-fos", "and", "junB", "contribute", "to", "C0162508#ent", "<e2>"], "h": {"id": "C0080138", "name": "C0080138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [6, 7]}}
{"token": ["These", "manifestations", "are", "more", "frequent", "in", "patients", "with", "C0867389#ent", "<e1>", "in", "patients", "with", "C0018133#ent", "<e2>"], "h": {"id": "C0867389", "name": "C0867389#ent", "pos": [8, 9]}, "relation": "has_nichd_parent", "t": {"id": "C0018133", "name": "C0018133#ent", "pos": [13, 14]}}
{"token": ["When", "mutant", "cells", "pulse-labeled", "for", "10", "min", "with", "[C]acetate", ",", "a", "greatly", "reduced", "amount", "of", "labeled", "C1538717#ent", "<e1>", "observed", ",", "while", "all", "other", "PSII", "C1305923#ent", "<e2>", "are", "synthesized", "normally", "."], "h": {"id": "C1538717", "name": "C1538717#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [24, 25]}}
{"token": ["The", "ability", "of", "captopril", "to", "inhibit", "the", "C4255305#ent", "<e1>", "action", "of", "angiotensin", "I", "C1439284#ent", "<e2>", ")", "in", "the", "rabbit", "aortic", "rings", "was", "not", "reduced", "by", "rHb1.1", "(", "15", "microM", ")", "."], "h": {"id": "C4255305", "name": "C4255305#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1439284", "name": "C1439284#ent", "pos": [13, 14]}}
{"token": ["C0381163#ent", "<e1>", "induced", "a", "rapid", "C0169101#ent", "<e2>", "activation", "followed", "by", "phosphorylation", "of", "the", "C0169101#ent", "<e2>", "substrates", "ERK1/2", "while", "FGF-2", "showed", "a", "less", "pronounced", "and", "delayed", "activation", "."], "h": {"id": "C0381163", "name": "C0381163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [5, 6]}}
{"token": ["C1539312#ent", "<e1>", "and", "the", "brominated", "analogs", "except", "TeBBPA", ",", "induced", "C1366500#ent", "<e2>", "pS2", "to", "the", "same", "extent", "as", "17beta-estradiol", ",", "although", "at", "much", "higher", "concentrations", "."], "h": {"id": "C1539312", "name": "C1539312#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366500", "name": "C1366500#ent", "pos": [10, 11]}}
{"token": ["The", "human", "C1425326#ent", "<e1>", "hOAT4", ")", "has", "been", "identified", "as", "the", "fourth", "C0597298#ent", "<e2>", "of", "OAT", "family", "."], "h": {"id": "C1425326", "name": "C1425326#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [12, 13]}}
{"token": ["This", "may", "be", "C0042373#ent", "<e1>", "such", "as", "nephropathy", ",", "retinopathy", "or", "C0152025#ent", "<e2>", ",", "and", "also", "macrovascular", "disease", "such", "as", "coronary", "heart", "disease", "stroke", "or", "peripheral", "artery", "disease"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0152025", "name": "C0152025#ent", "pos": [11, 12]}}
{"token": ["In", "a", "double-blind", "controlled", "study", "27", "indoor", "patients", "good", "results", "were", "achieved", "in", "the", "treatment", "of", "infected", "C0018567#ent", "<e1>", "by", "fusidic", "acid", "by", "the", "combination", "of", "fusidic", "acid", "C0063076#ent", "<e2>", "."], "h": {"id": "C0018567", "name": "C0018567#ent", "pos": [17, 18]}, "relation": "may_be_treated_by", "t": {"id": "C0063076", "name": "C0063076#ent", "pos": [28, 29]}}
{"token": ["C0529334#ent", "<e1>", "tissue", "transglutaminase", "TGase", "2", "was", "recently", "identified", "as", "an", "endomysial", "autoantigen", "C0007570#ent", "<e2>", "CD", ")", "."], "h": {"id": "C0529334", "name": "C0529334#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0007570", "name": "C0007570#ent", "pos": [13, 14]}}
{"token": ["C1268936#ent", "<e1>", "HUS", ")", "is", "characterized", "by", "the", "C1861185#ent", "<e2>", "microangiopathic", "hemolytic", "anemia", "and", "acute", "renal", "failure"], "h": {"id": "C1268936", "name": "C1268936#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1861185", "name": "C1861185#ent", "pos": [8, 9]}}
{"token": ["To", "determine", "the", "occupational", "significance", "tick-borne", "zoonoses", "sought", "serological", "evidence", "of", "C0024198#ent", "<e1>", "human", "monocytic", "ehrlichiosis", "HME", ")", "and", "C0483368#ent", "<e2>", "HGE", ")", "in", "a", "representative", "sample", "of", "farmworkers", "."], "h": {"id": "C0024198", "name": "C0024198#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0483368", "name": "C0483368#ent", "pos": [19, 20]}}
{"token": ["The", "study", "of", "the", "magnetic", "resonance", "pattern", "for", "identification", "and", "description", "of", "many", "genetic", "disorders", "to", "a", "group", "of", "non-specific", "leukodystrophy", "C0270612#ent", "<e1>", "with", "macrocephaly", "and", "mild", "clinical", "course", "van", "der", "Knaap", "syndrome", ",", "C2751843#ent", "<e2>", "subcortical", "cysts", "."], "h": {"id": "C0270612", "name": "C0270612#ent", "pos": [21, 22]}, "relation": "manifestation_of", "t": {"id": "C2751843", "name": "C2751843#ent", "pos": [34, 35]}}
{"token": ["Of", "the", "30", "patients", "with", "C0220655#ent", "<e1>", "eight", "patients", "(", "27", "%", ")", "showed", "C0008035#ent", "<e2>", "changes", "similar", "to", "those", "of", "the", "patients", "with", "empyema", "."], "h": {"id": "C0220655", "name": "C0220655#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008035", "name": "C0008035#ent", "pos": [14, 15]}}
{"token": ["The", "D-D-E", "motif", "identified", "in", "C0377359#ent", "<e1>", "from", "those", "in", "the", "other", "C0086376#ent", "<e2>", "in", "that", "the", "polypeptide", "segment", "between", "the", "second", "D", "third", "E", "C0377359#ent", "<e1>", "the", "shortest", ",", "24", "amino", "acids", "length", "."], "h": {"id": "C0377359", "name": "C0377359#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [12, 13]}}
{"token": ["Deletion", "analyses", "showed", "that", "C1423865#ent", "<e1>", "utilizes", "the", "different", "structural", "modules", "interact", "with", "its", "distinct", "target", "C0086376#ent", "<e2>", ",", "CIPKs", "and", "AtMTAN", "."], "h": {"id": "C1423865", "name": "C1423865#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}}
{"token": ["Non-steroidal", "anti-inflammatory", "drugs", "C0003211#ent", "<e1>", ")", "are", "used", "to", "treat", "diverse", "C1290884#ent", "<e2>", "of", "their", "ability", "to", "inhibit", "cyclooxygenase", "(", "COX", ")", ",", "which", "constitutes", "the", "rate-limiting", "enzyme", "in", "the", "biosynthetic", "cascade", "of", "prostaglandin", "PG", ")", "."], "h": {"id": "C0003211", "name": "C0003211#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [11, 12]}}
{"token": ["An", "analysis", "of", "inbred", "and", "congenic", "strains", "that", "the", "responsiveness", "to", "C1414134#ent", "<e1>", "was", "influenced", "by", "at", "least", "two", "C0017337#ent", "<e2>", ",", "one", "inside", "and", "one", "outside", "of", "the", "major", "histocompatibility", "complex"], "h": {"id": "C1414134", "name": "C1414134#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [19, 20]}}
{"token": ["Furthermore", ",", "the", "reduction", "of", "apoptosis", "by", "C1412322#ent", "<e1>", "inhibitor", "suggests", "that", "this", "apoptosis", "is", "associated", "with", "accumulation", "of", "C0001975#ent", "<e2>"], "h": {"id": "C1412322", "name": "C1412322#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0001975", "name": "C0001975#ent", "pos": [19, 20]}}
{"token": ["Intragonadal", "mechanisms", "regulating", "C3536949#ent", "<e1>", "production", "are", "the", "C0056677#ent", "<e2>", "for", "testicles", "and", "ovaries", "."], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0056677", "name": "C0056677#ent", "pos": [8, 9]}}
{"token": ["The", "present", "study", "investigated", "the", "clinical", "effects", "safety", "of", "open", "lung", "biopsy", "C1335230#ent", "<e1>", ")", "in", "patients", "with", "early-stage", "ARDS", "of", "suspected", "C0403632#ent", "<e2>"], "h": {"id": "C1335230", "name": "C1335230#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0403632", "name": "C0403632#ent", "pos": [22, 23]}}
{"token": ["The", "effects", "of", "dietary", "evening", "primrose", "oil", "rich", "in", "linoleic", "acid", "C0061078#ent", "<e1>", "were", "studied", "on", "platelets", "of", "multiple", "sclerosis", "C0026269#ent", "<e2>", ")", "patients", "and", "controls", "."], "h": {"id": "C0061078", "name": "C0061078#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026269", "name": "C0026269#ent", "pos": [20, 21]}}
{"token": ["Preincubation", "of", "microsomes", "of", "beta-naphthoflavone-treated", "rats", "with", "dihydralazine", "resulted", "in", "time-dependent", "loss", "of", "phenacetin", "O-deethylase", "activity", "(", "an", "indicator", "of", "C0207509#ent", "<e1>", ",", "showing", "inactivation", "of", "CYP1A2", "during", "the", "C0012271#ent", "<e2>"], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0012271", "name": "C0012271#ent", "pos": [29, 30]}}
{"token": ["Transplasma", "membrane", "electron", "transport", "HeLa", "cells", "measured", "by", "reduction", "of", "ferricyanide", "or", "diferric", "transferrin", "the", "presence", "of", "C0105267#ent", "<e1>", "is", "inhibited", "by", "low", "concentrations", "of", "C0085752#ent", "<e2>", "and", "C0085752#ent", "<e2>", "conjugated", "to", "diferric", "transferrin"], "h": {"id": "C0105267", "name": "C0105267#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0085752", "name": "C0085752#ent", "pos": [25, 26]}}
{"token": ["C0042847#ent", "<e1>", "be", "induced", "by", "long-term", "use", "of", "C0025598#ent", "<e2>", ",", "which", "may", "in", "turn", "lead", "to", "hyperhomocysteinemia", "."], "h": {"id": "C0042847", "name": "C0042847#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025598", "name": "C0025598#ent", "pos": [8, 9]}}
{"token": ["C4310614#ent", "<e1>", "shows", "no", "significant", "homology", "to", "other", "C0086376#ent", "<e2>", "in", "the", "Swiss-Prot", "data", "base"], "h": {"id": "C4310614", "name": "C4310614#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [8, 9]}}
{"token": ["A", "new", "H1", "antihistamine", "C0055147#ent", "<e1>", ",", "was", "studied", "to", "determine", "its", "effects", "on", "C0127400#ent", "<e2>", "and", "cellular", "infiltration", "the", "cutaneous", "late-phase", "response", "LPR", ")", "."], "h": {"id": "C0055147", "name": "C0055147#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0127400", "name": "C0127400#ent", "pos": [14, 15]}}
{"token": ["The", "results", "in", "the", "present", "study", "emphasize", "that", "in", "Arabidopsis", "thaliana", "genome", ",", "gamma-GTase", "encoded", "by", "a", "C1517488#ent", "<e1>", "of", "four", "C1417679#ent", "<e2>", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [21, 22]}}
{"token": ["In", "view", "of", "the", "prolonged", "C1368107#ent", "<e1>", "with", "use", "of", "teniposide", "and", "cytarabine", "as", "inducing", "C0035064#ent", "<e2>", ",", "the", "optimal", "role", "of", "this", "combination", "may", "be", "that", "of", "\"", "remission", "reinforcement", "therapy", "."], "h": {"id": "C1368107", "name": "C1368107#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [15, 16]}}
{"token": ["It", "has", "been", "shown", "that", "C0073393#ent", "<e1>", "(+)-9-hydroxylation", "is", "enantioselectively", "catalyzed", "by", "the", "polymorphic", "C3887685#ent", "<e2>", "in", "human", "liver", "."], "h": {"id": "C0073393", "name": "C0073393#ent", "pos": [5, 6]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [14, 15]}}
{"token": ["Acquired", "neuromuscular", "weakness", "to", "C0221423#ent", "<e1>", "polyneuropathy", "and", "C0026848#ent", "<e2>", "(", "CIPNM", ")", "frequently", "develops", "in", "patients", "hospitalized", "in", "the", "intensive", "care", "unit", "more", "than", "1", "week", "."], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [8, 9]}}
{"token": ["and", "C1428059#ent", "<e1>", "are", "important", "pathogens", "in", "C0031099#ent", "<e2>", "that", "the", "RefTx", "protocol", "is", "an", "acceptable", ",", "non-invasive", "alternative", "for", "the", "management", "of", "these", "patients", "."], "h": {"id": "C1428059", "name": "C1428059#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0031099", "name": "C0031099#ent", "pos": [7, 8]}}
{"token": ["The", "following", "liver", "C0003927#ent", "<e1>", "activities", "were", "measured", ":", "aldrin", "epoxidase", "ethoxyresorufin", "dealkylation", "EROD", ")", ",", "C0070319#ent", "<e2>", "BROD", ")", "and", "pentoxyresorufin", "dealkylation", "PROD", ")", "."], "h": {"id": "C0003927", "name": "C0003927#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0070319", "name": "C0070319#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "the", "3", "'", "splice", "site", "in", "C2681290#ent", "<e1>", "is", "a", "very", "rare", "C1417239#ent", "<e2>", "sequence", ";", "only", "three", "other", "genes", "in", "yeast", "use", "this", "nonconsensus", "sequence"], "h": {"id": "C2681290", "name": "C2681290#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417239", "name": "C1417239#ent", "pos": [14, 15]}}
{"token": ["C0052430#ent", "<e1>", "is", "characterised", "by", "a", "rapid", "onset", "of", "C1720748#ent", "<e2>", "a", "short", "half-life", "."], "h": {"id": "C0052430", "name": "C0052430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1720748", "name": "C1720748#ent", "pos": [9, 10]}}
{"token": ["C0086620#ent", "<e1>", "tested", "in-vitro", "for", "C0003308#ent", "<e2>", "and", "anti-microbial", "properties"], "h": {"id": "C0086620", "name": "C0086620#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [5, 6]}}
{"token": ["of", "tissue", ")", "of", "hepatic", "glycerol", "3-phosphate", "dehydrogenase", "was", "compared", "with", "the", "activities", "of", "the", "beta-oxoacyl-(acyl-carrier", "protein", "reductase", "component", "of", "C3658233#ent", "<e1>", "glycerol", "kinase", "EC", "2.7.1.30", ")", "and", "lactate", "dehydrogenase", "C3814816#ent", "<e2>", "."], "h": {"id": "C3658233", "name": "C3658233#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3814816", "name": "C3814816#ent", "pos": [30, 31]}}
{"token": ["The", "tissue", "inhibitor", "metalloproteases-1", ";", "an", "inhibitor", "of", "C0623362#ent", "<e1>", "does", "not", "inhibit", "cleavage", "by", "the", "C1335528#ent", "<e2>", "shedding", "machinery", ",", "also", "inhibited", "HER2", "ECD", "shedding", ",", "whereas", "tissue", "inhibitor", "metalloproteases-2", "did", "not", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [8, 9]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335528", "name": "C1335528#ent", "pos": [16, 17]}}
{"token": ["C0012422#ent", "<e1>", "(", "DDTC", ")", "and", "N-acetylcysteine", "(", "C1622105#ent", "<e2>", ")", "are", "nucleophile", "sulfur-containing", "compounds", "can", "protect", "the", "platinum-induced", "nephrotoxicity", "."], "h": {"id": "C0012422", "name": "C0012422#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1622105", "name": "C1622105#ent", "pos": [8, 9]}}
{"token": ["Cotransfection", "experiments", "suggested", "that", "TAO2", "selectively", "activates", "C1456386#ent", "<e1>", "and", "MEK6", "but", "not", "C0752313#ent", "<e2>", "4", ",", "or", "7", "."], "h": {"id": "C1456386", "name": "C1456386#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752313", "name": "C0752313#ent", "pos": [13, 14]}}
{"token": ["As", "the", "disease", "duration", "increasing", ",", "there", "was", "a", "higher", "C1422169#ent", "<e1>", "observed", "at", "earlier", "C0011849#ent", "<e2>", "stages", "and", "its", "decrease", "with", "the", "progressing", "of", "C0011849#ent", "<e2>", "."], "h": {"id": "C1422169", "name": "C1422169#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [15, 16]}}
{"token": ["The", "mean", "plasma", "clozapine/norclozapine", "and", "C0073393#ent", "<e1>", "not", "modified", "during", "C0168388#ent", "<e2>", "treatment", "."], "h": {"id": "C0073393", "name": "C0073393#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0168388", "name": "C0168388#ent", "pos": [10, 11]}}
{"token": ["C0850666#ent", "<e1>", "cause", "atrophic", "body", "gastritis", "achlorhydria", ",", "decreased", "iron", "absorption", "and", "consequent", "C3889248#ent", "<e2>", "."], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889248", "name": "C3889248#ent", "pos": [13, 14]}}
{"token": ["The", "author", "comes", "to", "a", "conclusion", "that", "C0004623#ent", "<e1>", "to", "the", "pathogenesis", "of", "viral", "hepatitides", "C0038160#ent", "<e2>", "other", "ones", ",", "that", "essentially", "influences", "the", "disease", "course"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}, "relation": "related_to", "t": {"id": "C0038160", "name": "C0038160#ent", "pos": [15, 16]}}
{"token": ["C0004698#ent", "<e1>", "NE", ")", "is", "a", "prevalent", "C0043528#ent", "<e2>", "throughout", "Europe", "and", "is", "caused", "by", "the", "Puumala", "type", "of", "hantavirus"], "h": {"id": "C0004698", "name": "C0004698#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [7, 8]}}
{"token": ["The", "impact", "of", "treatment", "of", "C0034013#ent", "<e1>", "CPP", ")", "with", "C1518041#ent", "<e2>", "GnRHa", ")", "on", "final", "height", "controversial", "."], "h": {"id": "C0034013", "name": "C0034013#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1518041", "name": "C1518041#ent", "pos": [10, 11]}}
{"token": ["Unlike", "a", "simple", "fungus", "ball", "the", "saprophytic", "form", "of", "aspergillosis", ")", ",", "the", "rounded", "density", "invasive", "C2350529#ent", "<e1>", "of", "sequestrum", "of", "C0011407#ent", "<e2>", "lung", "tissue", "to", "blood", "vessel", "invasion", "by", "Aspergillus", "hyphae"], "h": {"id": "C2350529", "name": "C2350529#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011407", "name": "C0011407#ent", "pos": [21, 22]}}
{"token": ["Almost", "all", "FTM-type", "C0009225#ent", "<e1>", "patients", "started", "to", "feel", "C2364135#ent", "<e2>", "with", "their", "sex", "before", "puberty", "and", "were", "sexually", "attracted", "to", "females", "."], "h": {"id": "C0009225", "name": "C0009225#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2364135", "name": "C2364135#ent", "pos": [9, 10]}}
{"token": ["To", "prevent", "delayed", "cardiomyopathy", "induced", "by", "C0085752#ent", "<e1>", "and", "subsequent", "severe", "congestive", "heart", "failure", "a", "monitoring", "schedule", "noninvasive", "techniques", "measure", "cardiac", "performance", "C0010290#ent", "<e2>", ",", "electrocardiographic", ",", "systolic", "time", "intervals", "echocardiography", "and", "quantitative", "radionuclide", "angiography", "has", "been", "used", "."], "h": {"id": "C0085752", "name": "C0085752#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010290", "name": "C0010290#ent", "pos": [22, 23]}}
{"token": ["Since", "the", "effect", "of", "blood", "vessels", "the", "activity", "of", "C3889275#ent", "<e1>", "has", "not", "yet", "been", "clarified", ",", "C0032144#ent", "<e2>", "PA", ")", "activity", "of", "C3889275#ent", "<e1>", "in", "the", "presence", "or", "absence", "of", "endothelial", "cells", "analyzed", "."], "h": {"id": "C3889275", "name": "C3889275#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032144", "name": "C0032144#ent", "pos": [17, 18]}}
{"token": ["Residues", "of", "C1540040#ent", "<e1>", ",", "IVR", ",", "and", "C1366515#ent", "<e2>", "are", "confirmed", "in", "fortified", "milk", "the", "20", "ppb", "level", "and", "in", "fortified", "beef", "liver", "40", "ppb", "."], "h": {"id": "C1540040", "name": "C1540040#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366515", "name": "C1366515#ent", "pos": [8, 9]}}
{"token": ["Four", "cases", "required", "hospitalization", "for", "complications", "including", "severe", "toxicity", ",", "C0042963#ent", "<e1>", "thrombophlebitis", "and", "C0020625#ent", "<e2>", "."], "h": {"id": "C0042963", "name": "C0042963#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0020625", "name": "C0020625#ent", "pos": [14, 15]}}
{"token": ["When", "C0037284#ent", "<e1>", "healing", "or", "absent", ",", "the", "levels", "of", "C0268532#ent", "<e2>", "in", "the", "patient's", "serum", "and", "superoxide", "generation", "neutrophils", "were", "higher", "than", "those", "of", "healthy", "controls", "lower", "than", "those", "in", "the", "inflammatory", "stages"], "h": {"id": "C0037284", "name": "C0037284#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0268532", "name": "C0268532#ent", "pos": [10, 11]}}
{"token": ["C3810659#ent", "<e1>", "has", "three", "conserved", "sequence", "motifs", "in", "common", "with", "C1426113#ent", "<e2>", ",", "is", "located", "at", "telomeres", ",", "and", "affects", "telomere", "length"], "h": {"id": "C3810659", "name": "C3810659#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1426113", "name": "C1426113#ent", "pos": [10, 11]}}
{"token": ["The", "following", "enzyme", "activities", "of", "the", "tryptophan-nicotinic", "acid", "pathway", "were", "studied", "in", "male", "New", "Zealand", "rabbits", "C0041260#ent", "<e1>", "intestine", "indole", "2,3-dioxygenase", "liver", "and", "kidney", "kynurenine", "3-monooxygenase", "kynureninase", ",", "kynurenine-oxoglutarate", "transaminase", "C0047442#ent", "<e2>", "and", "aminocarboxymuconate-semialdehyde", "decarboxylase"], "h": {"id": "C0041260", "name": "C0041260#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0047442", "name": "C0047442#ent", "pos": [30, 31]}}
{"token": ["The", "C1455836#ent", "<e1>", "HRPII", ")", "from", "Plasmodium", "falciparum", "been", "implicated", "as", "a", "C0121315#ent", "<e2>", "detoxifies", "free", "heme", "by", "its", "polymerization", "to", "inactive", "hemozoin", "."], "h": {"id": "C1455836", "name": "C1455836#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0121315", "name": "C0121315#ent", "pos": [12, 13]}}
{"token": ["In", "this", "study", ",", "we", "evaluated", "whether", "in", "vivo", "inhibition", "of", "C1522575#ent", "<e1>", "action", "could", "suppress", "retinal", "neovascularization", "a", "murine", "model", "of", "C0238309#ent", "<e2>"], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0238309", "name": "C0238309#ent", "pos": [22, 23]}}
{"token": ["Leu1011Pro", "C2712370#ent", "<e1>", "a", "conserved", "leucine", "residue", "in", "the", "C2D", "domain", "of", "C1418195#ent", "<e2>", "."], "h": {"id": "C2712370", "name": "C2712370#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1418195", "name": "C1418195#ent", "pos": [12, 13]}}
{"token": ["Authors", "present", "a", "rare", "case", "of", "a", "mild", "variant", "C0175702#ent", "<e1>", "IIH", ")", ",", "in", "a", "girl", "in", "whom", "C0027709#ent", "<e2>", "was", "diagnosed", "in", "the", "8th", "week", "of", "life", "."], "h": {"id": "C0175702", "name": "C0175702#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0027709", "name": "C0027709#ent", "pos": [19, 20]}}
{"token": ["Leptin-mediated", "activation", "of", "C1334291#ent", "<e1>", "(", "janus", "kinase", "2", "was", "upstream", "to", "the", "activation", "of", "PI-3K", "C0089793#ent", "<e2>", "and/or", "MAPK", "(", "mitogen-activated", "protein", "kinase", "signaling", "pathways"], "h": {"id": "C1334291", "name": "C1334291#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "it", "has", "been", "demonstrated", "that", "a", "single", "nucleotide", "polymorphism", "the", "C1708423#ent", "<e1>", "genetically", "correlated", "with", "C0004096#ent", "<e2>"], "h": {"id": "C1708423", "name": "C1708423#ent", "pos": [12, 13]}, "relation": "gene_associated_with_disease", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [17, 18]}}
{"token": ["From", "these", "results", "we", "concluded", "that", "Kupffer", "cells", "secrete", "a", "hepatocyte-stimulating", "factor", "stimulated", "by", "C0175697#ent", "<e1>", "and", "that", "glucocorticoid", "is", "essential", "for", "the", "induction", "of", "C1412046#ent", "<e2>", "rat", "hepatocytes", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1412046", "name": "C1412046#ent", "pos": [25, 26]}}
{"token": ["Serum", "eosinophil", "cationic", "protein", "ECP", ")", ",", "soluble", "interleukin-2", "receptor", "sIL-2R", ")", ",", "total", "serum", "IgE", ",", "IgG", "and", "IgM", "anti-IgE", "antibodies", "and", "C1415975#ent", "<e1>", "immune", "complexes", "evaluated", "in", "monitoring", "C1290884#ent", "<e2>", "as", "atopic", "dermatitis", "psoriasis", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [30, 31]}}
{"token": ["The", "authors", "suggest", "that", "C0064039#ent", "<e1>", "directly", "related", "to", "this", "patient's", "fatal", "case", "of", "C1279945#ent", "<e2>"], "h": {"id": "C0064039", "name": "C0064039#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1279945", "name": "C1279945#ent", "pos": [14, 15]}}
{"token": ["Even", "when", "treated", "with", "protocols", ",", "25", "to", "30", "%", "of", "systemic", "lupus", "erythematosus", "SLE", ")", "patients", "with", "C0744422#ent", "<e1>", "DPGN", ")", "evolve", "to", "end-stage", "renal", "disease", "C2316810#ent", "<e2>", ")", "."], "h": {"id": "C0744422", "name": "C0744422#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [27, 28]}}
{"token": ["C1706138#ent", "<e1>", "overexpression", "decreased", "gelsolin", ",", "C1456390#ent", "<e2>", ",", "and", "capping", "protein", "binding", "actin", "and", "increased", "that", "of", "ezrin", "."], "h": {"id": "C1706138", "name": "C1706138#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1456390", "name": "C1456390#ent", "pos": [6, 7]}}
{"token": ["Two", "such", "C0031727#ent", "<e1>", "have", "been", "identified", ",", "SPHK1", "and", "C3884157#ent", "<e2>", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [2, 3]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3884157", "name": "C3884157#ent", "pos": [10, 11]}}
{"token": ["This", "C1848862#ent", "<e1>", "is", "usually", "caused", "by", "C0017154#ent", "<e2>", "related", "or", "unrelated", "to", "Helicobacter", "pylori", "infection", "and", "long-term", "ingestion", "of", "antacids", "and", "biguanides", "."], "h": {"id": "C1848862", "name": "C1848862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0017154", "name": "C0017154#ent", "pos": [7, 8]}}
{"token": ["To", "provide", "information", "about", "the", "characteristics", "of", "diarrheal", "stool", "multi-drug", "resistant", "C0041466#ent", "<e1>", "observe", "the", "clinical", "course", "treatment", "with", "furazolidone", "or", "C0008809#ent", "<e2>", "."], "h": {"id": "C0041466", "name": "C0041466#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0008809", "name": "C0008809#ent", "pos": [21, 22]}}
{"token": ["C0050537#ent", "<e1>", "ASA", ")", "inhibits", "irreversibly", "the", "key", "C0027203#ent", "<e2>", "of", "the", "synthesis", "of", "these", "prostanoids", ",", "i.e.", "cyclo-oxygenase", "."], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [8, 9]}}
{"token": ["C2607914#ent", "<e1>", "rhinosinusitis", "are", "common", "C0029896#ent", "<e2>", "occurring", "in", "both", "children", "and", "adults", "that", "consume", "enormous", "amounts", "of", "health", "care", "dollars"], "h": {"id": "C2607914", "name": "C2607914#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [5, 6]}}
{"token": ["Two", "genes", "encoding", "NDST", "C0026794#ent", "<e1>", "have", "been", "described", ",", "one", "from", "rat", "liver", "(", "C1417617#ent", "<e2>", ")", "and", "another", "from", "murine", "mastocytoma", "NDST2", ")", "."], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417617", "name": "C1417617#ent", "pos": [15, 16]}}
{"token": ["Severe", "myoclonic", "epilepsy", "infancy", "(", "SMEI", ")", ",", "severe", "C0270850#ent", "<e1>", "infancy", "(", "SIGEI", ")", "with", "C0494475#ent", "<e2>", "GTCS", ")", ",", "and", "myoclonic", "astatic", "epilepsy", "MAE", ")", "may", "show", "semiological", "overlaps", "."], "h": {"id": "C0270850", "name": "C0270850#ent", "pos": [9, 10]}, "relation": "has_manifestation", "t": {"id": "C0494475", "name": "C0494475#ent", "pos": [16, 17]}}
{"token": ["We", "characterized", "rice", "cDNA", "sequences", "for", "OsDr1", "and", "OsDrAp1", ",", "which", "encode", "structural", "C4277608#ent", "<e1>", "of", "the", "eukaryotic", "general", "repressors", "C1333247#ent", "<e2>", "and", "DrAp1", ",", "respectively", "."], "h": {"id": "C4277608", "name": "C4277608#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333247", "name": "C1333247#ent", "pos": [20, 21]}}
{"token": ["The", "generation", "of", "these", "high-capacity", "AAV/Ad", "hybrid", "vectors", "takes", "place", "in", "Ad", "early", "region", "1", "cells", "and", "requires", "an", "Ad", "vector", "C2239387#ent", "<e1>", "deleted", "to", "complement", "in", "trans", "both", "C1412056#ent", "<e2>", "helper", "functions", "Ad", "structural", "proteins"], "h": {"id": "C2239387", "name": "C2239387#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1412056", "name": "C1412056#ent", "pos": [29, 30]}}
{"token": ["Expressed", "in", "the", "small", "intestine", "testis", ",", "and", "brain", "but", "not", "in", "normal", "lymphoid", "cells", "C1663627#ent", "<e1>", "shows", "greatest", "sequence", "similarity", "the", "insulin", "receptor", "subfamily", "C0031727#ent", "<e2>", "."], "h": {"id": "C1663627", "name": "C1663627#ent", "pos": [15, 16]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [25, 26]}}
{"token": ["C0096069#ent", "<e1>", "DUSP1", "(", "otherwise", "known", "as", "C0298690#ent", "<e2>", "MKP-1", ")", "dephosphorylates", "MAPKs", ",", "particularly", "p38", ",", "and", "negatively", "regulates", "innate", "immunity"], "h": {"id": "C0096069", "name": "C0096069#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0298690", "name": "C0298690#ent", "pos": [7, 8]}}
{"token": ["Further", "understanding", "of", "the", "mode", "of", "interaction", "of", "mutant", "C1335285#ent", "<e1>", "with", "other", "susceptibility", "genes", "uncover", "mechanisms", "common", "in", "various", "C0004364#ent", "<e2>"], "h": {"id": "C1335285", "name": "C1335285#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [20, 21]}}
{"token": ["Antibiotic", "prophylaxis", "routinely", "with", "ampicillin", "and", "C0025872#ent", "<e1>", "for", "48", "hours", "--", "prevented", "progression", "to", "C0036690#ent", "<e2>", ",", "and", "four", "days", "after", "the", "procedure", "all", "blood", "samples", "negative", "."], "h": {"id": "C0025872", "name": "C0025872#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0036690", "name": "C0036690#ent", "pos": [15, 16]}}
{"token": ["Methylation", "of", "PP2Ac", "subunit", "in", "vitro", "increases", "its", "activity", "toward", "both", "C0917783#ent", "<e1>", "a", "and", "a", "C0031684#ent", "<e2>", "."], "h": {"id": "C0917783", "name": "C0917783#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031684", "name": "C0031684#ent", "pos": [16, 17]}}
{"token": ["This", "regulon", "was", "comprised", "of", "mostly", "glycolytic", "enzymes", "(", "C0016762#ent", "<e1>", "enolase", ",", "pyruvate", "kinase", "and", "translation", "elongation", "factors", "GTPases", ":", "C1705442#ent", "<e2>", ",", "EF-G", ")", "."], "h": {"id": "C0016762", "name": "C0016762#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705442", "name": "C1705442#ent", "pos": [21, 22]}}
{"token": ["C0017375#ent", "<e1>", "encoding", "muscle", "creatine", "kinase", "gene", "ckm", "and", "brain", "creatine", "kinase", "C1332763#ent", "<e2>", "have", "been", "cloned", "."], "h": {"id": "C0017375", "name": "C0017375#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332763", "name": "C1332763#ent", "pos": [12, 13]}}
{"token": ["C0684275#ent", "<e1>", "B", "are", "C3641106#ent", "<e2>", "by", "a", "deficiency", "of", "factor", "VIII", "C", "or", "IX", ":", "C", "in", "plasma", "."], "h": {"id": "C0684275", "name": "C0684275#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C3641106", "name": "C3641106#ent", "pos": [4, 5]}}
{"token": ["C0014038#ent", "<e1>", "to", "the", "tissue", "injury", "by", "C0948008#ent", "<e2>"], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0948008", "name": "C0948008#ent", "pos": [7, 8]}}
{"token": ["Neither", "C1336937#ent", "<e1>", "or", "the", "C0052352#ent", "<e2>", "able", "to", "inhibit", "the", "binding", "of", "TSP", "or", "140", "K", "to", "11B", "cells", "."], "h": {"id": "C1336937", "name": "C1336937#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0052352", "name": "C0052352#ent", "pos": [5, 6]}}
{"token": ["The", "C3540471#ent", "<e1>", "was", "to", "investigate", "pancreatic", "B-cell", "function", "insulin", "sensitivity", "simultaneous", "pancreas-kidney", "(", "C2985150#ent", "<e2>", ")", "recipients", "with", "systemic", "or", "portal", "venous", "drained", "pancreas", "allograft", "using", "simple", "and", "easy", "tests", "."], "h": {"id": "C3540471", "name": "C3540471#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2985150", "name": "C2985150#ent", "pos": [14, 15]}}
{"token": ["A", "significant", "association", "between", "colitic", "arthropathy", "other", "complications", "of", "C0009324#ent", "<e1>", "such", "as", "C0032568#ent", "<e2>", ",", "perianal", "disease", "eye", "lesions", "skin", "eruptions", "aphthous", "ulceration", "and", "liver", "disease", "been", "demonstrated", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0032568", "name": "C0032568#ent", "pos": [13, 14]}}
{"token": ["Colonoscopy", "showed", "2-cm", "terminal", "ileal", "polyp", ",", "focal", "ulcer", "the", "cecum", ",", "and", "severe", "C0009324#ent", "<e1>", "mid-ascending", "colon", "rectum", ",", "with", "touch", "friability", ",", "spontaneous", "bleeding", "C0032568#ent", "<e2>", ",", "and", "ulceration", "."], "h": {"id": "C0009324", "name": "C0009324#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032568", "name": "C0032568#ent", "pos": [26, 27]}}
{"token": ["When", "C1565919#ent", "<e1>", "was", "expressed", ",", "the", "5'-promoter", "region", "of", "the", "C1527149#ent", "<e2>", "responded", "robustly", ",", "indicating", "that", "C1565919#ent", "<e1>", "induction", "of", "C1527149#ent", "<e2>", "expression", "is", "through", "transcription", "activation", "."], "h": {"id": "C1527149", "name": "C1527149#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1565919", "name": "C1565919#ent", "pos": [1, 2]}}
{"token": ["Eighteen", "serious", "C0024116#ent", "<e1>", "been", "encountered", "in", "10", "of", "16", "C1332416#ent", "<e2>", "cardiac", "transplant", "recipients", "."], "h": {"id": "C0024116", "name": "C0024116#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332416", "name": "C1332416#ent", "pos": [10, 11]}}
{"token": ["However", ",", "a", "non-linear", "relationship", "between", "both", "parameters", "was", "recorded", "when", "C0917964#ent", "<e1>", "was", "given", "in", "C3811061#ent", "<e2>", "Ringer's", "solution"], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3811061", "name": "C3811061#ent", "pos": [16, 17]}}
{"token": ["It", "was", "established", ",", "that", "ceruloplasmin", "at", "the", "concentration", "of", "1", "-", "40", "mg/kg", "stimulated", "both", "C0078956#ent", "<e1>", "and", "B", "--", "systems", "of", "immunity", "and", "prevented", "C1334159#ent", "<e2>", "activity", "of", "tumor", "growth"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1334159", "name": "C1334159#ent", "pos": [26, 27]}}
{"token": ["However", ",", "suppression", "of", "C0108855#ent", "<e1>", "activity", "after", "C1135135#ent", "<e2>", "treatment", "correlated", "with", "C1135135#ent", "<e2>", "sensitivity", "(", "P", "<", "0.0001", ")", "."], "h": {"id": "C0108855", "name": "C0108855#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1135135", "name": "C1135135#ent", "pos": [8, 9]}}
{"token": ["Whereas", "bile", "ducts", "vascular", "endothelia", "not", "show", "relevant", "changes", "in", "alpha", "chain", "expression", "in", "C0023895#ent", "<e1>", "hepatocytes", "de", "novo", "membranous", "alpha", "3", "6", "in", "C0019158#ent", "<e2>"], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [14, 15]}, "relation": "related_to", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [24, 25]}}
{"token": ["His", "C0023895#ent", "<e1>", "over", "4", "yr", "from", "mild", "hepatitis", "moderate", "C0019158#ent", "<e2>", "with", "cirrhosis", "despite", "therapy", "with", "interferon-alpha", ",", "and", "phlebotomy", "plus", "interferon", "."], "h": {"id": "C0023895", "name": "C0023895#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0019158", "name": "C0019158#ent", "pos": [10, 11]}}
{"token": ["and", "Km", "values", "for", "the", "mutants", "P286Q", "and", "E288A", "with", "L-asparagine", "and", "C4284130#ent", "<e1>", "were", "comparable", "with", "those", "of", "the", "C2987364#ent", "<e2>", "enzyme", "."], "h": {"id": "C4284130", "name": "C4284130#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}}
{"token": ["The", "available", "data", "suggest", "that", "C0025039#ent", "<e1>", "and", "dimenhydrinate", "are", "the", "C0003297#ent", "<e2>", "that", "present", "the", "lowest", "risk", "of", "teratogenicity", ";", "C0025039#ent", "<e1>", "is", "the", "drug", "of", "first", "choice", "."], "h": {"id": "C0025039", "name": "C0025039#ent", "pos": [5, 6]}, "relation": "has_therapeutic_class", "t": {"id": "C0003297", "name": "C0003297#ent", "pos": [11, 12]}}
{"token": ["Multidrug", "resistance", "mammalian", "cancer", "cells", "the", "result", "of", "C0001622#ent", "<e1>", "of", "the", "P-glycoprotein", ",", "can", "be", "reversed", "by", "certain", "C0010592#ent", "<e2>", ",", "particularly", "valspodar", "."], "h": {"id": "C0001622", "name": "C0001622#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [19, 20]}}
{"token": ["Progress", "has", "been", "made", "in", "the", "development", "of", "POC", "tests", "for", "HIV", ",", "C0153188#ent", "<e1>", ",", "trichomonas", ",", "and", "C0085166#ent", "<e2>", "but", "more", "work", "is", "needed", "for", "chlamydia", "and", "gonorrhea", "."], "h": {"id": "C0153188", "name": "C0153188#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085166", "name": "C0085166#ent", "pos": [19, 20]}}
{"token": ["Terminally", "differentiating", "mouse", "muscle", "cells", "used", "to", "examine", "the", "relationship", "between", "C1417575#ent", "<e1>", "withdrawal", "from", "the", "cell", "cycle", "the", "levels", "of", "C3853636#ent", "<e2>", "DHFR", ")", "mRNA", "and", "DHFR", "activity", "."], "h": {"id": "C1417575", "name": "C1417575#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3853636", "name": "C3853636#ent", "pos": [21, 22]}}
{"token": ["In", "contrast", ",", "C1417575#ent", "<e1>", "withdrawal", "did", "not", "result", "in", "reduced", "C3853636#ent", "<e2>", "activity", "."], "h": {"id": "C1417575", "name": "C1417575#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3853636", "name": "C3853636#ent", "pos": [11, 12]}}
{"token": ["C1456390#ent", "<e1>", "of", "surface-bound", "proteins", "uncovers", "a", "tumor-selective", "heat", "shock", "protein", "70", "C1415760#ent", "<e2>", ")", "membrane", "expression", "provides", "a", "target", "structure", "for", "human", "NK", "cells"], "h": {"id": "C1456390", "name": "C1456390#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415760", "name": "C1415760#ent", "pos": [12, 13]}}
{"token": ["Children", "with", "C0865440#ent", "<e1>", "a", "significantly", "shorter", "duration", "of", "symptoms", "than", "children", "without", "C0025297#ent", "<e2>", "."], "h": {"id": "C0865440", "name": "C0865440#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0025297", "name": "C0025297#ent", "pos": [13, 14]}}
{"token": ["Recent", "research", "has", "demonstrated", "a", "strong", "genetic", "linkage", "C1867743#ent", "<e1>", "pCAD", ")", "and", "C0242339#ent", "<e2>", "."], "h": {"id": "C1867743", "name": "C1867743#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0242339", "name": "C0242339#ent", "pos": [13, 14]}}
{"token": ["He", "showed", "C0006430#ent", "<e1>", "and", "C0030554#ent", "<e2>", "in", "left", "half", "body", "clavicular", ",", "C0006430#ent", "<e1>", "in", "left", "hand", "vertical", "gaze", "palsy", "convergence", "disturbance"], "h": {"id": "C0030554", "name": "C0030554#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0006430", "name": "C0006430#ent", "pos": [2, 3]}}
{"token": ["We", "demonstrate", "a", "lack", "of", "ciliary", "localization", "of", "somatostatin", "receptor", "type", "3", "Sstr3", ")", "and", "melanin-concentrating", "hormone", "receptor", "1", "C1825952#ent", "<e1>", ")", "in", "neurons", "from", "mice", "lacking", "the", "C1412747#ent", "<e2>", "or", "Bbs4", "gene"], "h": {"id": "C1825952", "name": "C1825952#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1412747", "name": "C1412747#ent", "pos": [28, 29]}}
{"token": ["Treatment", "with", "the", "adipogenic", "inducers", "dexamethasone", "C0006644#ent", "<e1>", "causes", "an", "increase", "in", "C1414398#ent", "<e2>", "mRNA", "levels", "specifically", "in", "preadipocytes", ",", "and", "C0006644#ent", "<e1>", "is", "the", "main", "effector", "of", "ENC-1", "expression"], "h": {"id": "C1414398", "name": "C1414398#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0006644", "name": "C0006644#ent", "pos": [6, 7]}}
{"token": ["These", "cases", "illustrate", "the", "discussion", "and", "demonstrate", "that", "C0042384#ent", "<e1>", "mechanisms", "may", "be", "involved", "in", "the", "C0042373#ent", "<e2>", "of", "primary", "antiphospholipid", "syndrome", "though", "thrombosis", "occur", "more", "frequently", "."], "h": {"id": "C0042384", "name": "C0042384#ent", "pos": [8, 9]}, "relation": "related_to", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [16, 17]}}
{"token": ["The", "clinical", "sensitivity", "specificity", "of", "the", "assay", "for", "C0751339#ent", "<e1>", "79", "%", "and", "96", "%", ",", "and", "for", "C0026896#ent", "<e2>", "%", "and", "96", "%", ",", "respectively", "."], "h": {"id": "C0751339", "name": "C0751339#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0026896", "name": "C0026896#ent", "pos": [18, 19]}}
{"token": ["Postoperative", "complications", "included", "one", "death", "due", "to", "C0085605#ent", "<e1>", "two", "cases", "of", "C0740766#ent", "<e2>", "and", "one", "persistent", "chest", "wall", "discomfort", "the", "trocar", "sites"], "h": {"id": "C0085605", "name": "C0085605#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0740766", "name": "C0740766#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "other", "protein-tyrosine", "phosphatases", "C0284927#ent", "<e1>", ")", "appear", "to", "be", "critically", "involved", "in", "major", "C0029896#ent", "<e2>", "such", "as", "cancer", "and", "autoimmunity", "."], "h": {"id": "C0284927", "name": "C0284927#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029896", "name": "C0029896#ent", "pos": [16, 17]}}
{"token": ["Huntington's", "disease", "HD", ")", "and", "other", "C0032500#ent", "<e1>", "(", "polyQ", ")", "neurodegenerative", "diseases", "characterized", "by", "neuronal", "accumulation", "the", "C0012634#ent", "<e2>", "suggesting", "that", "the", "cellular", "ability", "handle", "abnormal", "proteins", "is", "compromised", "."], "h": {"id": "C0032500", "name": "C0032500#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [18, 19]}}
{"token": ["The", "treatment", "of", "complications", "such", "as", "reversal", "reaction", "C0343467#ent", "<e1>", "involves", "the", "use", "of", "C0032950#ent", "<e2>", "."], "h": {"id": "C0343467", "name": "C0343467#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "the", "effect", "of", "C1416933#ent", "<e1>", "in", "this", "oral", "candidiasis", "model", "is", "not", "due", "to", "direct", "C0003308#ent", "<e2>"], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003308", "name": "C0003308#ent", "pos": [19, 20]}}
{"token": ["Two", "dosage", "schedules", ",", "8", "mg/kg", "per", "dose", "daily", "and", "10", "mg/kg", "per", "dose", "tds", "of", "C0039771#ent", "<e1>", "evaluated", "in", "C0004096#ent", "<e2>", "children", "."], "h": {"id": "C0039771", "name": "C0039771#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [20, 21]}}
{"token": ["However", ",", "when", "C3274822#ent", "<e1>", "was", "measured", "without", "these", "C0003015#ent", "<e2>", "the", "inhibition", "of", "C3274822#ent", "<e1>", "was", "parallel", "to", "the", "suppression", "of", "ANG", "I", "II.(ABSTRACT", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0003015", "name": "C0003015#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3274822", "name": "C3274822#ent", "pos": [3, 4]}}
{"token": ["Blood", "mononuclear", "cells", "MNC", ")", "from", "9", "randomly", "selected", "patients", "with", "C0677607#ent", "<e1>", "stimulated", "in", "vitro", "pokeweed", "C0026249#ent", "<e2>", "(", "PWM", ")", ",", "a", "polyclonal", "B", "lymphocyte", "activator"], "h": {"id": "C0677607", "name": "C0677607#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026249", "name": "C0026249#ent", "pos": [17, 18]}}
{"token": ["These", "data", "suggest", "that", ",", "although", "C1333216#ent", "<e1>", "inhibition", "during", "C0085176#ent", "<e2>", "exposure", "produced", "growth", "inhibition", "C1333216#ent", "<e1>", "catalytic", "activity", "h", "after", "drug", "removal", "a", "more", "accurate", "predictor", "of", "lethality", "in", "these", "two", "cell", "lines"], "h": {"id": "C0085176", "name": "C0085176#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333216", "name": "C1333216#ent", "pos": [6, 7]}}
{"token": ["Hypogonadism", "has", "been", "described", "in", "patients", "with", "C2931689#ent", "<e1>", "has", "not", "been", "evaluated", "in", "other", "C0206157#ent", "<e2>", "."], "h": {"id": "C2931689", "name": "C2931689#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0206157", "name": "C0206157#ent", "pos": [15, 16]}}
{"token": ["Ninety-two", "patients", "with", "C0018801#ent", "<e1>", "to", "digitalis", "and", "diuretic", "therapy", "C0006938#ent", "<e2>", "(", "n", "=", "50", ")", "or", "placebo", "(", "n", "=", "42", ")", "added", "to", "their", "therapeutic", "regimen", "a", "randomized", ",", "double-blind", "trial"], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [10, 11]}}
{"token": ["A", "randomized", "open-label", "clinical", "trial", "conducted", "to", "determine", "whether", "mortality", ",", "readmission", ",", "or", "quality", "of", "life", "between", "C0018801#ent", "<e1>", "patients", "managed", "with", "C0006938#ent", "<e2>", "plus", "diuretics", "and", "those", "with", "digoxin", "plus", "diuretics", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [18, 19]}, "relation": "may_be_treated_by", "t": {"id": "C0006938", "name": "C0006938#ent", "pos": [23, 24]}}
{"token": ["C1334353#ent", "<e1>", "is", "an", "autosomal", "dominant", "inherited", "disorder", "by", "C0004134#ent", "<e2>", ",", "slow", "saccades", "and", "hyporeflexia", "."], "h": {"id": "C1334353", "name": "C1334353#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [9, 10]}}
{"token": ["We", "have", "studied", "the", "capacity", "of", "various", "C0127082#ent", "<e1>", "interstitial", "collagenase", "stromelysin", ",", "matrilysin", ",", "and", "C1334523#ent", "<e2>", "to", "degrade", "the", "COL1", "domain", "of", "collagen", "XIV"], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334523", "name": "C1334523#ent", "pos": [16, 17]}}
{"token": ["C3887898#ent", "<e1>", "a", "unique", "age-specific", "epileptic", "syndrome", "is", "often", "associated", "with", "focal", "or", "C0743491#ent", "<e2>", "can", "result", "in", "severe", "neurodevelopmental", "delay", "retardation", "."], "h": {"id": "C3887898", "name": "C3887898#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0743491", "name": "C0743491#ent", "pos": [13, 14]}}
{"token": ["This", "patient", "illustrates", "for", "the", "first", "time", "that", "a", "C1414083#ent", "<e1>", "abnormality", "can", "cause", "a", "secondary", "deficiency", "of", "C1416776#ent", "<e2>", "in", "dystrophinopathy", "."], "h": {"id": "C1414083", "name": "C1414083#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416776", "name": "C1416776#ent", "pos": [18, 19]}}
{"token": ["While", "traditional", "surgical", "approaches", "been", "directed", "at", "the", "relief", "of", "cholangitis", "and", "C0400979#ent", "<e1>", "liver", "transplantation", "emerged", "as", "definitive", "therapy", "for", "patients", "with", "C0566602#ent", "<e2>", "complicated", "by", "cirrhosis", "or", "recurrent", "bouts", "of", "cholangitis", "."], "h": {"id": "C0400979", "name": "C0400979#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0566602", "name": "C0566602#ent", "pos": [23, 24]}}
{"token": ["Haemoglobin-based", "oxygen", "carriers", "(", "HBOCs", ")", "are", "assessed", "as", "C0032121#ent", "<e1>", "patients", "with", "perioperative", "anaemia", "patients", "at", "risk", "for", "perioperative", "C0010054#ent", "<e2>"], "h": {"id": "C0032121", "name": "C0032121#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [20, 21]}}
{"token": ["Patients", "with", "unimpaired", "renal", "function", "be", "treated", "in", "normal", "dosage", "great", "danger", "of", "renal", "or", "other", "side", "effects", "C0014838#ent", "<e1>", "for", "avoiding", "oedema", "while", "passing", "C0392525#ent", "<e2>", "after", "plastic", "surgery"], "h": {"id": "C0014838", "name": "C0014838#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0392525", "name": "C0392525#ent", "pos": [25, 26]}}
{"token": ["The", "organic", "polycations", "C0031957#ent", "<e1>", "and", "ruthenium", "red", "modulated", "the", "conductance", "of", "C1416601#ent", "<e2>", "in", "a", "similar", "way", "as", "Ca2", "+", "or", "Mg2", "+", "."], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416601", "name": "C1416601#ent", "pos": [12, 13]}}
{"token": ["C0019025#ent", "<e1>", "frequent", "in", "South", "East", "Asia", "results", "in", "a", "C0002878#ent", "<e2>", "homozygous", "patients", "."], "h": {"id": "C0019025", "name": "C0019025#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0002878", "name": "C0002878#ent", "pos": [10, 11]}}
{"token": ["Seventeen", "patients", "with", "intractable", "C0036572#ent", "<e1>", "have", "been", "treated", "with", "medium-chain", "triglyceride", "C0724624#ent", "<e2>", ")", "diet", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0724624", "name": "C0724624#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "two", "cases", "of", "TTP", "which", "have", "been", "presented", "during", "rapidly", "progressive", "lupus", "nephritis", "with", "C0494475#ent", "<e1>", "thrombocytopenia", "and", "C0221021#ent", "<e2>"], "h": {"id": "C0494475", "name": "C0494475#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0221021", "name": "C0221021#ent", "pos": [20, 21]}}
{"token": ["Full-length", "RT-PCR", "analysis", "the", "CYP", "27", "gene", "in", "a", "patient", "from", "one", "of", "the", "C0631180#ent", "<e1>", "families", "revealed", "one", "major", "and", "an", "additional", "C0039070#ent", "<e2>"], "h": {"id": "C0631180", "name": "C0631180#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0039070", "name": "C0039070#ent", "pos": [23, 24]}}
{"token": ["In", "conclusion", ",", "C3539691#ent", "<e1>", "is", "an", "obligatory", "partner", "of", "C1826259#ent", "<e2>", "in", "regulating", "lipogenic", "enzyme", "genes", "in", "liver", "."], "h": {"id": "C3539691", "name": "C3539691#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1826259", "name": "C1826259#ent", "pos": [10, 11]}}
{"token": ["A", "variety", "of", "drugs", "effective", "against", "clinical", "C0004238#ent", "<e1>", ",", "including", "flecainide", ",", "C0033429#ent", "<e2>", ",", "procainamide", ",", "and", "sotalol", ",", "have", "been", "found", "to", "terminate", "experimental", "C0004238#ent", "<e1>", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0033429", "name": "C0033429#ent", "pos": [13, 14]}}
{"token": ["The", "positive", "effect", "of", "valsartan/amlodipine", "combination", "on", "C0004238#ent", "<e1>", "recurrence", "was", "more", "evident", "in", "patients", "treated", "with", "amiodarone", "or", "C0033429#ent", "<e2>", "than", "in", "patients", "treated", "with", "antiarrhythmic", "drugs", "without", "antiarrhythmic", "treatment", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0033429", "name": "C0033429#ent", "pos": [19, 20]}}
{"token": ["In", "this", "paper", "we", "report", "the", "sequence", "analysis", "11", "additional", "familial", "cases", ":", "8", "were", "diagnosed", "as", "possibly", "affected", "with", "C1336578#ent", "<e1>", ",", "and", "3", "were", "affected", "with", "C0013264#ent", "<e2>"], "h": {"id": "C1336578", "name": "C1336578#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0013264", "name": "C0013264#ent", "pos": [28, 29]}}
{"token": ["The", "method", "was", "validated", "and", "then", "applied", "to", "determine", "the", "pharmacokinetic", "of", "C0740123#ent", "<e1>", "in", "ten", "C0003872#ent", "<e2>", "patient", "dermis", "after", "oral", "intake", "this", "drug", "."], "h": {"id": "C0740123", "name": "C0740123#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003872", "name": "C0003872#ent", "pos": [16, 17]}}
{"token": ["COS", "cells", "transfected", "with", "C3540804#ent", "<e1>", "resulted", "in", "the", "formation", "of", "intracellular", "C0088353#ent", "<e2>", "treated", "with", "thrombin", "or", "trypsin", "."], "h": {"id": "C3540804", "name": "C3540804#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0088353", "name": "C0088353#ent", "pos": [12, 13]}}
{"token": ["Moreover", ",", "activation", "of", "C0086376#ent", "<e1>", "by", "Mas-7", "augmented", "IL-18", "reverse", "transcriptase", "polymerase", "chain", "reaction", "in", "OA", "C1705295#ent", "<e2>", "but", "not", "in", "RA", "C1705295#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705295", "name": "C1705295#ent", "pos": [17, 18]}}
{"token": ["Eicosapentaenoic", "acid", "EPA", ")", "has", "been", "reported", "to", "have", "a", "potent", "anti-aggregatory", "activity", "and", "to", "be", "efficiently", "metabolized", "by", "C0003691#ent", "<e1>", ",", "not", "by", "C1565830#ent", "<e2>", "in", "platelets", "."], "h": {"id": "C0003691", "name": "C0003691#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [24, 25]}}
{"token": ["Boswellic", "acids", "inhibited", "the", "leukotriene", "synthesis", "5-lipoxygenase", ",", "but", "did", "not", "affect", "the", "C0003691#ent", "<e1>", "and", "the", "C1565830#ent", "<e2>"], "h": {"id": "C0003691", "name": "C0003691#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [17, 18]}}
{"token": ["Phosphorylation", "elicited", "by", "C1418727#ent", "<e1>", "prior", "to", "PKC", "prevents", "nuclear", "envelope", "disassembly", "even", "though", "C3537289#ent", "<e2>", "is", "phosphorylated", "."], "h": {"id": "C1418727", "name": "C1418727#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3537289", "name": "C3537289#ent", "pos": [14, 15]}}
{"token": ["The", "crystal", "structure", "the", "C1307053#ent", "<e1>", "complex", "with", "imatinib", "closely", "resembles", "that", "of", "C0939537#ent", "<e2>", "and", "c-Kit*imatinib", ",", "and", "differs", "significantly", "from", "the", "inactive", "\"", "Src/CDK", "\"", "conformation", "of", "the", "Src", "family", "kinases"], "h": {"id": "C1307053", "name": "C1307053#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0939537", "name": "C0939537#ent", "pos": [13, 14]}}
{"token": ["In", "conclusion", ",", "the", "long-term", "efficacy", "of", "alkali", "therapy", "prevention", "of", "recurrent", "stone", "formation", "with", "C3849574#ent", "<e1>", "is", "confirmed", "when", "the", "patient", "takes", "enough", "alkali", "agents", "the", "C0262655#ent", "<e2>", "well", "controlled", "."], "h": {"id": "C3849574", "name": "C3849574#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0262655", "name": "C0262655#ent", "pos": [27, 28]}}
{"token": ["The", "location", "of", "the", "endogenous", "inhibitor", "protein", "C1412690#ent", "<e1>", ")", "in", "the", "rotor/stator", "architecture", "of", "the", "bovine", "C0949692#ent", "<e2>", "studied", "by", "reversible", "cross-linking", "with", "dithiobis(succinimidylpropionate)", "soluble", "F1I", "and", "intact", "F1F0I", "complexes", "of", "submitochondrial", "particles"], "h": {"id": "C1412690", "name": "C1412690#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0949692", "name": "C0949692#ent", "pos": [17, 18]}}
{"token": ["Inhibition", "of", "C0257535#ent", "<e1>", "achieved", "with", "the", "chemical", "inhibitor", "SB203580", ",", "or", "C0851887#ent", "<e2>", "a", "dominant-negative", "form", "of", "p38alpha", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0851887", "name": "C0851887#ent", "pos": [12, 13]}}
{"token": ["High", "doses", "10", "and", "20", "mg/kg", ")", "of", "C0733398#ent", "<e1>", ",", "an", "alpha-receptor", "blocker", ",", "significantly", "antagonized", "the", "C0002763#ent", "<e2>", "ETOH", "action", "but", "had", "no", "significant", "effect", "on", "the", "depressant", "phase"], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002763", "name": "C0002763#ent", "pos": [18, 19]}}
{"token": ["Thus", "the", "FHBL", "mice", "are", "more", "susceptible", "to", "diet-induced", "fatty", "liver", "despite", "relatively", "reduced", "intestinal", "C1420709#ent", "<e1>", "absorption", "capacity", "on", "a", "C1538440#ent", "<e2>"], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [21, 22]}}
{"token": ["Thus", "C1412365#ent", "<e1>", "a", "structurally", "similar", "cytochrome", "P450", "to", "catalyse", "almost", "all", "microsomal", "metabolism", "C0014277#ent", "<e2>", "."], "h": {"id": "C1412365", "name": "C1412365#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0014277", "name": "C0014277#ent", "pos": [14, 15]}}
{"token": ["The", "interaction", "of", "Cdk4", "with", "C1332722#ent", "<e1>", "in", "vitro", "not", "sensitive", "to", "changes", "in", "C1705556#ent", "<e2>", "levels", "."], "h": {"id": "C1332722", "name": "C1332722#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [14, 15]}}
{"token": ["Neither", "the", "phosphorylation", "of", "histone", "H3", "accompanies", "chromosome", "condensation", "condensin", "recruitment", "to", "C0008546#ent", "<e1>", "seen", "when", "C1706168#ent", "<e2>", "function", "was", "compromised", "."], "h": {"id": "C0008546", "name": "C0008546#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1706168", "name": "C1706168#ent", "pos": [16, 17]}}
{"token": ["The", "competitive", "NMDA", "antagonist", "3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic", "acid", "(", "C0047123#ent", "<e1>", ")", "substituted", "for", "C0030883#ent", "<e2>", "at", "doses", "that", "did", "not", "disrupt", "rates", "of", "responding", "."], "h": {"id": "C0047123", "name": "C0047123#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030883", "name": "C0030883#ent", "pos": [12, 13]}}
{"token": ["Esophageal", "candidiasis", "often", "recognized", "in", "C0004096#ent", "<e1>", "patients", "receiving", "long-term", "C0117996#ent", "<e2>", "FP", ")", "dry", "powder", "Diskhaler", ")", "inhalation", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [5, 6]}, "relation": "may_be_prevented_by", "t": {"id": "C0117996", "name": "C0117996#ent", "pos": [10, 11]}}
{"token": ["The", "pentavalent", "antimonial", "(", "Sb5", "+", ")", "C0025179#ent", "<e1>", "is", "the", "drug", "of", "choice", "for", "the", "treatment", "of", "C0023283#ent", "<e2>", "CL", ")", "in", "Brazil", "."], "h": {"id": "C0025179", "name": "C0025179#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0023283", "name": "C0023283#ent", "pos": [18, 19]}}
{"token": ["Renal", "biopsy", "a", "membranoproliferative", "pattern", "of", "C0268731#ent", "<e1>", "five", "cases", ",", "and", "a", "C4288921#ent", "<e2>", "mesangial", "proliferative", "features", "in", "one", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C4288921", "name": "C4288921#ent", "pos": [13, 14]}}
{"token": ["Since", "the", "eosinophil", "cationic", "protein", "ECP", ")", ",", "in", "its", "activated", "form", ",", "is", "cytotoxic", ",", "we", "propose", "a", "pathogenic", "role", "of", "the", "C1306759#ent", "<e1>", "infiltration", "in", "C0014848#ent", "<e2>", "."], "h": {"id": "C1306759", "name": "C1306759#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0014848", "name": "C0014848#ent", "pos": [27, 28]}}
{"token": ["Overall", ",", "we", "demonstrate", "that", "the", "loss", "of", "C2987364#ent", "<e1>", "htt", "influences", "motor", "dysfunction", "hyperkinesia", ",", "C0156312#ent", "<e2>", "impaired", "lifespan", "in", "YAC128", "mice", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0156312", "name": "C0156312#ent", "pos": [16, 17]}}
{"token": ["It", "generally", "affects", "patients", "over", "50", "years", "of", "age", "suffering", "from", "myocardial", "infarction", "congestive", "heart", "failure", "C0003504#ent", "<e1>", "renal", "or", "C0019202#ent", "<e2>", "patients", "following", "cardiac", "surgery"], "h": {"id": "C0003504", "name": "C0003504#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0019202", "name": "C0019202#ent", "pos": [20, 21]}}
{"token": ["C0014070#ent", "<e1>", "ME", ")", "is", "a", "C0476214#ent", "<e2>", "dominant", "clinical", "features", "are", "exercise-induced", "muscle", "fatigue", "disturbances", "in", "cognitive", "functioning", "symptoms", "of", "overactivity", "of", "the", "autonomic", "nervous", "system"], "h": {"id": "C0014070", "name": "C0014070#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0476214", "name": "C0476214#ent", "pos": [6, 7]}}
{"token": ["However", ",", "a", "phenotype", "very", "similar", "to", "FH", "may", "also", "be", "caused", "by", "defects", "in", "other", "C0017337#ent", "<e1>", "like", "the", "C0017337#ent", "<e1>", "for", "apolipoprotein", "(apo)", "B-100", "autosomal", "recessive", "hypercholesterolaemia", "C1863512#ent", "<e1>", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1863512", "name": "C1863512#ent", "pos": [29, 30]}}
{"token": ["In", "fact", ",", "the", "most", "potent", "polyamine", "C0003376#ent", "<e1>", "were", "among", "the", "least", "effective", "C0003195#ent", "<e2>", "."], "h": {"id": "C0003376", "name": "C0003376#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [14, 15]}}
{"token": ["Mucopolysaccharidosis", "type", "I", "a", "lysosomal", "disease", "to", "mutations", "in", "the", "C1442485#ent", "<e1>", "resulting", "in", "deficiency", "of", "C0020818#ent", "<e2>", "and", "accumulation", "of", "glycosaminoglycans", "(", "GAGs", ")", "."], "h": {"id": "C1442485", "name": "C1442485#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0020818", "name": "C0020818#ent", "pos": [16, 17]}}
{"token": ["alpha", "1-protease", "inhibitor", "C0443619#ent", "<e1>", "but", "not", "immunoreactive", "C0812377#ent", "<e2>", "inhibitor", "increased", "proportionally", "to", "EP", "score", "."], "h": {"id": "C0443619", "name": "C0443619#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0812377", "name": "C0812377#ent", "pos": [8, 9]}}
{"token": ["Two", "human", "neuroblastoma", "cell", "lines", "NCG", "and", "C0004002#ent", "<e1>", ",", "were", "used", "to", "study", "the", "cytotoxic", "effect", "gamma", "linolenic", "acid", "C0061078#ent", "<e2>", ")", "."], "h": {"id": "C0004002", "name": "C0004002#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061078", "name": "C0061078#ent", "pos": [20, 21]}}
{"token": ["Taken", "alone", ",", "these", "data", "would", "suggest", "that", "Ca2", "+", "and", "C0700541#ent", "<e1>", "were", "competing", "for", "the", "same", "site", "on", "the", "C1334284#ent", "<e2>"], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1334284", "name": "C1334284#ent", "pos": [21, 22]}}
{"token": ["These", "data", "suggest", "that", "C0119104#ent", "<e1>", "is", "an", "effective", "C0003211#ent", "<e2>", "evaluated", "in", "the", "PMA", "model", "of", "edema", ",", "and", "implicates", "PKC", "as", "a", "potential", "target", "in", "the", "development", "of", "novel", "anti-inflammatory", "agents"], "h": {"id": "C0119104", "name": "C0119104#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [9, 10]}}
{"token": ["Glycogen", "storage", "disease", "type", "1b", "C0268146#ent", "<e1>", ")", "is", "a", "rare", "autosomal", "recessive", "disorder", "by", "C0020615#ent", "<e2>", ",", "hepatomegaly", ",", "and", "growth", "retardation", "and", "associated-for", "unknown", "reasons-", "with", "neutropenia", "and", "neutrophil", "dysfunction"], "h": {"id": "C0268146", "name": "C0268146#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [15, 16]}}
{"token": ["Rats", "were", "injected", "with", "C0885378#ent", "<e1>", "or", "the", "C0072225#ent", "<e2>", "control", "for", "4", "-", "7", "days", "."], "h": {"id": "C0885378", "name": "C0885378#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0072225", "name": "C0072225#ent", "pos": [8, 9]}}
{"token": ["In", "four", "patients", "with", "clinical", "and", "laboratory", "manifestations", "the", "C0019061#ent", "<e1>", "the", "administration", "of", "aspirin", "and", "C0012582#ent", "<e2>", "was", "associated", "with", "dramatic", "and", "rapid", "increase", "in", "the", "platelet", "count"], "h": {"id": "C0019061", "name": "C0019061#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012582", "name": "C0012582#ent", "pos": [16, 17]}}
{"token": ["Three", "children", "with", "the", "C0019061#ent", "<e1>", "treated", "with", "heparin", ",", "aspirin", ",", "and", "C0012582#ent", "<e2>", "."], "h": {"id": "C0019061", "name": "C0019061#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0012582", "name": "C0012582#ent", "pos": [13, 14]}}
{"token": ["C1257843#ent", "<e1>", "associated", "with", "white", "blood", "over", "15", "000/mm3", "in", "17", "patients", "and", "C1412332#ent", "<e2>", "concentrations", "of", "less", "than", "30", "g/1", "in", "18", "."], "h": {"id": "C1257843", "name": "C1257843#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412332", "name": "C1412332#ent", "pos": [13, 14]}}
{"token": ["Traditionally", ",", "most", "patients", "are", "treated", "with", "C3539185#ent", "<e1>", ",", "cyclophosphamide", "(", "CTX", ")", "or", "C1562036#ent", "<e2>", "(", "C-I", ")", "."], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1562036", "name": "C1562036#ent", "pos": [15, 16]}}
{"token": ["The", "neuromuscular", "effects", "equipotent", "doses", "of", "non-depolarizing", "muscle", "relaxants", "for", "endotracheal", "intubation", "studied", "in", "27", "children", "anesthetized", "with", "C0936073#ent", "<e1>", ",", "nitrous", "oxide/oxygen", ",", "and", "C0028426#ent", "<e2>", "."], "h": {"id": "C0936073", "name": "C0936073#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0028426", "name": "C0028426#ent", "pos": [25, 26]}}
{"token": ["This", "study", "aimed", "to", "explore", "the", "C0242912#ent", "<e1>", "of", "androgen", "against", "C0021390#ent", "<e2>", "in", "neonatal", "rats", "and", "the", "possible", "mechanism", "."], "h": {"id": "C0242912", "name": "C0242912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0021390", "name": "C0021390#ent", "pos": [11, 12]}}
{"token": ["The", "stoichiometry", "of", "heme", "interaction", "with", "C0389003#ent", "<e1>", "determined", "by", "titration", "of", "the", "C0003589#ent", "<e2>", "purified", "from", "sheep", "seminal", "vesicles"], "h": {"id": "C0389003", "name": "C0389003#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003589", "name": "C0003589#ent", "pos": [13, 14]}}
{"token": ["There", "was", "little", "change", "in", "C1704947#ent", "<e1>", ",", "indicating", "that", "the", "Ca++", "desensitization", "by", "C0246904#ent", "<e2>", "was", "not", "attributable", "to", "decreasing", "C1704947#ent", "<e1>", "."], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0246904", "name": "C0246904#ent", "pos": [14, 15]}}
{"token": ["There", "were", "no", "synergistic", "effects", "C0147513#ent", "<e1>", "acting", "on", "the", "HF", "and", "guanabenz", "acting", "on", "the", "C1417869#ent", "<e2>", "or", "the", "LC", "."], "h": {"id": "C0147513", "name": "C0147513#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417869", "name": "C1417869#ent", "pos": [16, 17]}}
{"token": ["In", "addition", ",", "C0245514#ent", "<e1>", "also", "suppressed", "low-potassium-induced", "apoptosis", "in", "cerebellar", "granule", "neurons", "in", "a", "C0044602#ent", "<e2>", "manner", "."], "h": {"id": "C0245514", "name": "C0245514#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [15, 16]}}
{"token": ["At", "comparable", "levels", "of", "arterial", "pressure", "left", "ventricular", "oxygen", "consumption", "normal", "zone", "blood", "flow", "was", "significantly", "higher", "during", "C0012582#ent", "<e1>", "than", "during", "C0022180#ent", "<e2>", "and", "norepinephrine", "."], "h": {"id": "C0012582", "name": "C0012582#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0022180", "name": "C0022180#ent", "pos": [22, 23]}}
{"token": ["The", "lack", "of", "the", "alpha6", "chain", "does", "not", "obviously", "result", "in", "disease", ",", "in", "particular", "leiomyomatosis", ",", "as", "is", "seen", "in", "C1567741#ent", "<e1>", "patients", "with", "deletions", "involving", "the", "C2347281#ent", "<e2>", "and", "COL4A6", "genes"], "h": {"id": "C1567741", "name": "C1567741#ent", "pos": [21, 22]}, "relation": "disease_has_associated_gene", "t": {"id": "C2347281", "name": "C2347281#ent", "pos": [28, 29]}}
{"token": ["To", "compare", "vigabatrin", "with", "C0006949#ent", "<e1>", "as", "monotherapy", "in", "newly", "diagnosed", "children", "with", "C0085417#ent", "<e2>", "order", "to", "evaluate", "the", "efficacy", "and", "tolerability", "of", "both", "drugs", "."], "h": {"id": "C0006949", "name": "C0006949#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0085417", "name": "C0085417#ent", "pos": [13, 14]}}
{"token": ["In", "patients", "with", "C0038358#ent", "<e1>", "optimal", "dose", "duration", "of", "Helicobacter", "pylori", "treatment", "containing", "C0028978#ent", "<e2>", "(", "O", ")", ",", "metronidazole", "(", "M", ")", "and", "clarithromycin", "(", "C", ")", "has", "yet", "to", "be", "established", "."], "h": {"id": "C0038358", "name": "C0038358#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0028978", "name": "C0028978#ent", "pos": [13, 14]}}
{"token": ["The", "remaining", "3", "genes", "direct", "the", "synthesis", "of", "C0033164#ent", "<e1>", "env", "(", "envelope", "proteins", ",", "pol", "(", "C1335440#ent", "<e2>", ")", ",", "and", "gag", "(", "internal", "proteins", "."], "h": {"id": "C0033164", "name": "C0033164#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1335440", "name": "C1335440#ent", "pos": [17, 18]}}
{"token": ["Clinical", "trials", "caloric", "restriction", "sirtuin", "activators", "and", "C1513344#ent", "<e1>", "both", "pathological", "aging", "such", "as", "C0524620#ent", "<e2>", "diabetes", "mellitus", "rheumatoid", "arthritis", "and", "Werner", "syndrome", "physiological", "aging", "been", "proposed", "."], "h": {"id": "C1513344", "name": "C1513344#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [14, 15]}}
{"token": ["A", "combination", "of", "medical", "therapy-often", ",", "C0064113#ent", "<e1>", "or", "fluconazole-and", "surgical", "d\u00e9bridement", "is", "often", "needed", "to", "control", "C0030409#ent", "<e2>"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0030409", "name": "C0030409#ent", "pos": [17, 18]}}
{"token": ["C1846059#ent", "<e1>", "a", "constellation", "of", "antibody", "deficiency", "spondyloepiphyseal", "dysplasia", "facial", "dysmorphism", "growth", "retardation", "and", "C0854723#ent", "<e2>"], "h": {"id": "C1846059", "name": "C1846059#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0854723", "name": "C0854723#ent", "pos": [14, 15]}}
{"token": ["The", "results", "strongly", "suggest", "that", "gsp", "mutation", "is", "absent", "in", "affected", "and", "normal", "tissues", "this", "patient", "and", "that", "the", "association", "of", "C0020502#ent", "<e1>", "and", "fibrous", "dysplasia", "not", "represent", "a", "variant", "of", "the", "C0242292#ent", "<e2>"], "h": {"id": "C0020502", "name": "C0020502#ent", "pos": [21, 22]}, "relation": "manifestation_of", "t": {"id": "C0242292", "name": "C0242292#ent", "pos": [32, 33]}}
{"token": ["Furthermore", ",", "we", "report", "that", "C2002111#ent", "<e1>", ",", "an", "alternatively", "spliced", "isoform", "of", "C1420552#ent", "<e2>", "binds", "Eps15", ",", "a", "clathrin", "coat-associated", "protein", "."], "h": {"id": "C2002111", "name": "C2002111#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420552", "name": "C1420552#ent", "pos": [13, 14]}}
{"token": ["Based", "on", "the", "Michaelis-Menten", "kinetics", ",", "the", "C1420727#ent", "<e1>", "had", "an", "increasing", "reactivity", "with", "C2239387#ent", "<e2>", ",", "E3", ",", "E2", ",", "and", "EE2", ",", "in", "increasing", "order", "."], "h": {"id": "C1420727", "name": "C1420727#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2239387", "name": "C2239387#ent", "pos": [14, 15]}}
{"token": ["Multicellular", "tumor", "spheroids", "C1420740#ent", "<e1>", ")", "have", "been", "exposed", "to", "C0729502#ent", "<e2>", "in", "vitro", "nitrogen", "mustard", "or", "in", "vivo", "cyclophosphamide", ")", "and", "analyzed", "in", "vitro", "terms", "of", "altered", "growth", "patterns"], "h": {"id": "C1420740", "name": "C1420740#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [10, 11]}}
{"token": ["It", "has", "been", "found", "that", "patients", "suffering", "from", "chronic", "renal", "failure", "C0022661#ent", "<e1>", ")", "are", "prone", "to", "develop", "acquired", "C1691228#ent", "<e2>", "which", "may", "subsequently", "lead", "to", "the", "development", "of", "renal", "cell", "carcinoma", "RCC", ")", "."], "h": {"id": "C0022661", "name": "C0022661#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1691228", "name": "C1691228#ent", "pos": [19, 20]}}
{"token": ["The", "experiments", "demonstrate", "an", "oncogenic", "role", "for", "C1335238#ent", "<e1>", "and", "suggest", "that", "C3274701#ent", "<e2>", "may", "be", "useful", "in", "the", "diagnosis", "and", "treatment", "of", "thyroid", "carcinoma"], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [7, 8]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C3274701", "name": "C3274701#ent", "pos": [12, 13]}}
{"token": ["We", "found", "that", "2", "-", "3-fold", "overexpression", "of", "the", "protein", "stimulated", "the", "homologous", "recombination", "integrated", "genes", "by", "20-fold", "indicating", "that", "C0287666#ent", "<e1>", "is", "a", "functional", "and", "key", "C0027203#ent", "<e2>", "of", "an", "intrachromosomal", "recombination", "pathway"], "h": {"id": "C0287666", "name": "C0287666#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [27, 28]}}
{"token": ["C0268450#ent", "<e1>", "manifested", "by", "C0085570#ent", "<e2>", "hypomagnesemia", ",", "hypocalciuria", ",", "normotensive", "hyperreninemia", "hyperaldosteronism", "."], "h": {"id": "C0268450", "name": "C0268450#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0085570", "name": "C0085570#ent", "pos": [4, 5]}}
{"token": ["Previous", "reports", "of", "autoantibodies", "to", "C0031691#ent", "<e1>", "have", "suggested", "associations", "with", "autoimmune", "polyglandular", "syndrome", "type", "I", "C0730307#ent", "<e2>"], "h": {"id": "C0031691", "name": "C0031691#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0730307", "name": "C0730307#ent", "pos": [16, 17]}}
{"token": ["This", "sequence", "is", "highly", "homologous", "with", "the", "translated", "reading", "frame", "RCC1", ",", "a", "C0079429#ent", "<e1>", "reportedly", "involved", "in", "regulating", "onset", "of", "mammalian", "C1826786#ent", "<e2>"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1826786", "name": "C1826786#ent", "pos": [22, 23]}}
{"token": ["Using", "tsBN2", "cells", "as", "a", "recipient", "of", "DNA-mediated", "gene", "transfer", "we", "investigated", "a", "human", "C0079429#ent", "<e1>", "that", "is", "responsible", "for", "regulation", "of", "C1826786#ent", "<e2>", "cell", "proliferation"], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1826786", "name": "C1826786#ent", "pos": [22, 23]}}
{"token": ["The", "present", "paper", "reports", "the", "study", "on", "a", "C1334456#ent", "<e1>", "in", "rat", "liver", "which", "decomposes", "S-adenosylmethionine", "into", "5'-methylthioadenosine", "and", "C0000481#ent", "<e2>", "."], "h": {"id": "C1334456", "name": "C1334456#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000481", "name": "C0000481#ent", "pos": [19, 20]}}
{"token": ["These", "data", "indicate", "that", "C3831153#ent", "<e1>", "may", "impair", "both", "C1417685#ent", "<e2>", "and", "endothelium-dependent", "relaxation", "of", "corporal", "smooth", "muscle", "and", "may", "contribute", "to", "the", "etiology", "of", "impotence", "."], "h": {"id": "C3831153", "name": "C3831153#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417685", "name": "C1417685#ent", "pos": [9, 10]}}
{"token": ["This", "may", "explain", "the", "high", "level", "of", "putrescine", "but", "low", "levels", "of", "spermidine", "and", "C0031957#ent", "<e1>", "in", "the", "C0240225#ent", "<e2>"], "h": {"id": "C0031957", "name": "C0031957#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0240225", "name": "C0240225#ent", "pos": [18, 19]}}
{"token": ["To", "measure", "PA", ",", "C3540525#ent", "<e1>", "was", "incubated", "with", "C1367553#ent", "<e2>", ",", "and", "the", "formation", "of", "plasmin", "was", "followed", "by", "its", "ability", "to", "cleave", "globin", "."], "h": {"id": "C3540525", "name": "C3540525#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1367553", "name": "C1367553#ent", "pos": [9, 10]}}
{"token": ["We", "evaluated", "the", "long-term", "effects", "of", "C0068897#ent", "<e1>", "on", "cognition", "and", "EEG", "in", "37", "patients", "with", "C0014547#ent", "<e2>"], "h": {"id": "C0068897", "name": "C0068897#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0014547", "name": "C0014547#ent", "pos": [16, 17]}}
{"token": ["Although", "the", "rate", "of", "synonymous", "substitutions", "very", "similar", "between", "C1415467#ent", "<e1>", "and", "COI", "C1417679#ent", "<e2>", "there", "were", "strong", "discrepancies", "between", "them", "in", "terms", "of", "the", "number", "of", "nonsynonymous", "substitutions"], "h": {"id": "C1415467", "name": "C1415467#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [13, 14]}}
{"token": ["On", "GTP", "hydrolysis", "induced", "by", "the", "GTPase-activating", "protein", "C1423774#ent", "<e1>", ",", "the", "complexes", "were", "disassembled", "and", "C0162508#ent", "<e2>", "dissociated", "from", "the", "membrane", "."], "h": {"id": "C1423774", "name": "C1423774#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [16, 17]}}
{"token": ["Both", "mutations", "cause", "a", "degradation", "of", "C1705831#ent", "<e1>", "a", "temperature-sensitive", "manner", "through", "an", "C0101555#ent", "<e2>", "and", "proteasome-independent", "pathway", "."], "h": {"id": "C1705831", "name": "C1705831#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [13, 14]}}
{"token": ["We", "report", "the", "case", "of", "a", "38-year-old", "female", "patient", ",", "affected", "with", "Kartagener", "syndrome", "C0008780#ent", "<e1>", ",", "who", "developed", "seropositive", "and", "C0038013#ent", "<e2>"], "h": {"id": "C0008780", "name": "C0008780#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0038013", "name": "C0038013#ent", "pos": [21, 22]}}
{"token": ["Cytochromes", "P450", "P450s", ")", "and", "glutathione", "S-transferases", "C1865138#ent", "<e1>", ")", "constitute", "two", "important", "C0027203#ent", "<e2>", "families", "involved", "in", "carcinogen", "metabolism", "."], "h": {"id": "C1865138", "name": "C1865138#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [13, 14]}}
{"token": ["The", "authors", "describe", "a", "young", "man", "with", "hemophilia", "complicated", "by", "chronic", "hepatic", "dysfunction", "C1260903#ent", "<e1>", ",", "and", "immune", "thrombocytopenia", "resulted", "in", "a", "C0005779#ent", "<e2>"], "h": {"id": "C1260903", "name": "C1260903#ent", "pos": [13, 14]}, "relation": "has_nichd_parent", "t": {"id": "C0005779", "name": "C0005779#ent", "pos": [22, 23]}}
{"token": ["Many", "of", "the", "C0086376#ent", "<e1>", "that", "form", "the", "complexes", "in", "C1425993#ent", "<e2>", "are", "shared", "with", "the", "other", "two", "NCRs", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1425993", "name": "C1425993#ent", "pos": [10, 11]}}
{"token": ["C3640008#ent", "<e1>", "these", "effects", "with", "BQ-123", ",", "PD", "142893", ",", "C0253336#ent", "<e2>", ",", "and", "S6c", "suggests", "signaling", "through", "an", "ET(A", ")", "receptor", "subtype", "in", "osteoblasts", "."], "h": {"id": "C3640008", "name": "C3640008#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0253336", "name": "C0253336#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "focus", "on", "C1425697#ent", "<e1>", "and", "show", "that", "the", "protein", "evolutionary", "rate", "of", "this", "C0017337#ent", "<e2>", "is", "significantly", "higher", "in", "primates", "than", "rodents", "or", "carnivores", "."], "h": {"id": "C1425697", "name": "C1425697#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["The", "presence", "of", "C0854706#ent", "<e1>", "PDA", ",", "and", "C0034067#ent", "<e2>", "ILE", ")", "was", "assessed", "."], "h": {"id": "C0854706", "name": "C0854706#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034067", "name": "C0034067#ent", "pos": [8, 9]}}
{"token": ["Lipid", "peroxidation", "initiated", "by", "the", "production", "of", "oxygen-free", "radicals", "it", "is", "increased", "in", "a", "wide", "variety", "of", "C0029896#ent", "<e1>", ",", "including", "various", "C0852336#ent", "<e2>", "and", "in", "hemoglobin", "disorders"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0852336", "name": "C0852336#ent", "pos": [22, 23]}}
{"token": ["A", "patient", "with", "an", "11", "year", "history", "of", "C0024790#ent", "<e1>", "with", "severe", "C0000737#ent", "<e2>"], "h": {"id": "C0024790", "name": "C0024790#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0000737", "name": "C0000737#ent", "pos": [12, 13]}}
{"token": ["C0157749#ent", "<e1>", "bone", "are", "unusual", "manifestations", "of", "C0023860#ent", "<e2>"], "h": {"id": "C0157749", "name": "C0157749#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023860", "name": "C0023860#ent", "pos": [7, 8]}}
{"token": ["Selective", "oestrogen", "receptor", "modulators", "C0618111#ent", "<e1>", ")", "and", "statins", "(", "C0286651#ent", "<e2>", ")", "have", "been", "shown", "to", "reduce", "the", "risk", "of", "cardiovascular", "disease", "associated", "with", "postmenopausal", "status", "."], "h": {"id": "C0618111", "name": "C0618111#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0286651", "name": "C0286651#ent", "pos": [10, 11]}}
{"token": ["Polyinosinic", ":", "polycytidylic", "acid", "poly", "I", "C", ")", "is", "a", "C0032589#ent", "<e1>", "elicits", "immune", "responses", "to", "those", "observed", "during", "C0042769#ent", "<e2>"], "h": {"id": "C0032589", "name": "C0032589#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [19, 20]}}
{"token": ["In", "this", "study", ",", "we", "report", "a", "novel", "interaction", "between", "C1538716#ent", "<e1>", "PKD1", ";", "formerly", "known", "as", "C2987025#ent", "<e2>", "PKCmu", ")", "]", "and", "E-cadherin", "."], "h": {"id": "C1538716", "name": "C1538716#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2987025", "name": "C2987025#ent", "pos": [17, 18]}}
{"token": ["Metallothionein", "(", "MT", ")", "an", "intracellular", ",", "low-molecular", ",", "cysteine-rich", "protein", "which", "is", "inducible", "by", "dietary", "C3541396#ent", "<e1>", "(", "Zn", ")", ",", "has", "been", "implicated", "in", "sequestering", "C0812281#ent", "<e2>", "."], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [27, 28]}}
{"token": ["In", "the", "present", "experiments", "it", "was", "shown", "that", "the", "C0003158#ent", "<e1>", "efficacy", "of", "C0025023#ent", "<e2>", "was", "significantly", "impaired", "in", "the", "rat", "on", "either", "an", "iron", "deficient", "a", "protein", "deficient", "diet", "."], "h": {"id": "C0003158", "name": "C0003158#ent", "pos": [9, 10]}, "relation": "therapeutic_class_of", "t": {"id": "C0025023", "name": "C0025023#ent", "pos": [13, 14]}}
{"token": ["Participants", "were", "then", "given", "a", "C1416596#ent", "<e1>", "requiring", "them", "to", "match", "rotated", "blocks", "used", "in", "the", "C0723303#ent", "<e2>", "and", "Metzler", "[", "13", "]", "experiment", "."], "h": {"id": "C1416596", "name": "C1416596#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0723303", "name": "C0723303#ent", "pos": [16, 17]}}
{"token": ["Overexpression", "of", "C1416448#ent", "<e1>", "led", "to", "a", "decrease", "of", "the", "C0011854#ent", "<e2>", "PIP3", "production", "as", "well", "as", "Akt/PKB", "activation", "and", "MAPK", "stimulation", "."], "h": {"id": "C1416448", "name": "C1416448#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [10, 11]}}
{"token": ["Multiparameter", ",", "side", "by", "side", "comparisons", "that", "only", "those", "cells", "that", "expressed", "wild", "type", "IL-2R", "beta", "to", "C0879590#ent", "<e1>", "by", "increased", "cellular", "proliferation", "accumulation", "of", "the", "c-myc", "C0694890#ent", "<e2>", ",", "and", "activation", "of", "protein", "tyrosine", "kinase"], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0694890", "name": "C0694890#ent", "pos": [27, 28]}}
{"token": ["Before", "matching", ",", "the", "47", "subjects", "with", "prevalent", "C4049859#ent", "<e1>", "had", "higher", "levels", "of", "fibrinogen", ",", "von", "Willebrand", "factor", "and", "C0078956#ent", "<e2>", "those", "without", "C4049859#ent", "<e1>", ",", "all", "p", "<", "or", "=", "0.03", "."], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0078956", "name": "C0078956#ent", "pos": [20, 21]}}
{"token": ["Glycine", "is", "metabolized", "in", "isolated", "renal", "cortical", "tubules", "to", "stochiometric", "qualities", "of", "ammonia", ",", "C1537986#ent", "<e1>", "and", "serine", "by", "the", "combined", "actions", "of", "the", "glycine-cleavage-enzyme", "complex", "C1420038#ent", "<e2>"], "h": {"id": "C1537986", "name": "C1537986#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1420038", "name": "C1420038#ent", "pos": [26, 27]}}
{"token": ["p21rasGAP", "antibodies", "were", "used", "to", "examine", "the", "phosphorylated", "state", "of", "C2984553#ent", "<e1>", "in", "agonist-treated", "platelets", "and", "to", "C1875400#ent", "<e2>", "potential", "GAP-kinase", "complexes", "."], "h": {"id": "C2984553", "name": "C2984553#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [17, 18]}}
{"token": ["Here", "we", "report", "that", "C1420466#ent", "<e1>", "protects", "ovarian", "cancer", "from", "apoptosis", "induced", "by", "C0729502#ent", "<e2>", "activates", "Akt", "pathway", "a", "p53-dependent", "manner", "."], "h": {"id": "C1420466", "name": "C1420466#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0729502", "name": "C0729502#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "we", "conclude", "that", "PEA3", "and", "C1421565#ent", "<e1>", "synergistically", "stimulate", "the", "transcription", "of", "the", "C1421580#ent", "<e2>"], "h": {"id": "C1421565", "name": "C1421565#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421580", "name": "C1421580#ent", "pos": [15, 16]}}
{"token": ["The", "C3888274#ent", "<e1>", "generated", "by", "the", "C3888274#ent", "<e1>", "3-OST-3", ")", ",", "and", "it", "provides", "binding", "sites", "viral", "glycoprotein", "D", "gD", ")", "."], "h": {"id": "C3888274", "name": "C3888274#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3888274", "name": "C3888274#ent", "pos": [1, 2]}}
{"token": ["The", "ability", "of", "the", "benzodiazepine", "antagonist", "flumazenil", "to", "precipitate", "a", "withdrawal", "subjective", "state", "rats", "receiving", "C0012010#ent", "<e1>", "investigated", "in", "a", "biased", "conditioned", "place", "aversion", "C3812677#ent", "<e2>", ")", "procedure", "."], "h": {"id": "C0012010", "name": "C0012010#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C3812677", "name": "C3812677#ent", "pos": [24, 25]}}
{"token": ["The", "Ala12", "allele", "of", "the", "peroxisome", "proliferator-activated", "receptor-gamma", "gene", "C1706243#ent", "<e1>", ")", "decreases", "the", "lipolysis", "of", "C0017860#ent", "<e2>", "in", "adipose", "tissue", "which", "results", "in", "the", "accumulation", "of", "fatty", "acids", "adipocytes", "."], "h": {"id": "C1706243", "name": "C1706243#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [16, 17]}}
{"token": ["The", "phorbol", "ester", "12-O-tetradecanoylphorbol-13-acetate", "(", "C0078956#ent", "<e1>", ")", ",", "a", "potent", "activator", "of", "Ca(2+)-", "and", "phospholipid-dependent", "protein", "kinase", "C0211705#ent", "<e2>", ",", "stimulates", "luteinizing", "hormone", "LH", ")", "release", "from", "rat", "pituitary", "cells"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [18, 19]}}
{"token": ["C0151313#ent", "<e1>", "found", "to", "be", "associated", "with", "C1997249#ent", "<e2>"], "h": {"id": "C0151313", "name": "C0151313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1997249", "name": "C1997249#ent", "pos": [7, 8]}}
{"token": ["Five", "diseases", "are", "covered", "in", "the", "screening", "program", "C0010308#ent", "<e1>", "phenylketonuria", ",", "homocystinuria", ",", "C0268151#ent", "<e2>", ",", "and", "glucose-6-phosphate", "dehydrogenase", "deficiency"], "h": {"id": "C0010308", "name": "C0010308#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0268151", "name": "C0268151#ent", "pos": [14, 15]}}
{"token": ["We", "conclude", "that", "SP", "coupling", "to", "PI-PLC", "through", "the", "C4050010#ent", "<e1>", "the", "rat", "anterior", "pituitary", "a", "C0086376#ent", "<e2>", "mechanism", "distinct", "from", "the", "G-proteins", "associated", "with", "adenylate", "cyclase", "Gs", "and", "Gi", "."], "h": {"id": "C4050010", "name": "C4050010#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [16, 17]}}
{"token": ["The", "associations", "of", "five", "volatile", "analytes", "hydrogen", "sulfide", "C0010648#ent", "<e1>", ",", "dimethyl", "sulfide", "dichloromethane", ",", "and", "C3495432#ent", "<e2>", "with", "various", "cyclodextrins", "were", "examined", "."], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3495432", "name": "C3495432#ent", "pos": [16, 17]}}
{"token": ["A", "growing", "interest", "in", "the", "beneficial", "properties", "of", "manipulating", "the", "endocannabinoid", "system", "led", "to", "the", "possible", "involvement", "of", "C1413154#ent", "<e1>", "in", "the", "control", "of", "C0014038#ent", "<e2>"], "h": {"id": "C1413154", "name": "C1413154#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [24, 25]}}
{"token": ["Concomitantly", ",", "they", "up-regulated", "C1417679#ent", "<e1>", "involved", "in", "lymphocyte", "proliferation", "survival", ",", "most", "notably", "interleukin", "10", "receptor", "alpha", "C1416381#ent", "<e2>", ")", "and", "CD20", ",", "the", "target", "for", "antibody", "therapy", "Rituxan", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416381", "name": "C1416381#ent", "pos": [18, 19]}}
{"token": ["We", "report", "a", "case", "of", "a", "young", "female", "with", "cervicalgia", "and", "C0018681#ent", "<e1>", "with", "fatal", "posterior", "circulation", "cerebrovascular", "accident", "after", "C1413752#ent", "<e2>", "."], "h": {"id": "C0018681", "name": "C0018681#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1413752", "name": "C1413752#ent", "pos": [20, 21]}}
{"token": ["We", "have", "recently", "reported", "the", "cloning", "and", "characterization", "of", "the", "human", "C1704897#ent", "<e1>", "H-twist", ")", ",", "which", "encodes", "an", "evolutionarily", "conserved", "C1420632#ent", "<e2>"], "h": {"id": "C1704897", "name": "C1704897#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1420632", "name": "C1420632#ent", "pos": [21, 22]}}
{"token": ["To", "describe", "the", "laboratory", "and", "C0037285#ent", "<e1>", "lamotrigine", "toxicity", "presenting", "as", "C3541994#ent", "<e2>"], "h": {"id": "C0037285", "name": "C0037285#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3541994", "name": "C3541994#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "the", "drug", "was", "ineffective", "when", "these", "lesions", "were", "already", "established", ",", "and", "also", "failed", "to", "inhibit", "the", "C0302809#ent", "<e1>", "course", "of", "C0152451#ent", "<e2>", "an", "enhanced", "autologous", "phase"], "h": {"id": "C0302809", "name": "C0302809#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0152451", "name": "C0152451#ent", "pos": [24, 25]}}
{"token": ["The", "effect", "of", "C3540783#ent", "<e1>", "is", "specific", "for", "peroxisome", "proliferator-activated", "receptor-alpha", "PPARalpha", ")", "because", "a", "high-affinity", "ligand", "C1335238#ent", "<e2>", ",", "the", "thiazolidinedione", "BRL", ",", "lowered", "triglyceride", "levels", ",", "but", "was", "unable", "to", "suppress", "fibrinogen", "expression", "."], "h": {"id": "C3540783", "name": "C3540783#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335238", "name": "C1335238#ent", "pos": [17, 18]}}
{"token": ["CLR", "and", "CTR", "are", "members", "of", "the", "class", "II", "family", "B", "G-protein-coupled", "receptors", "(", "C3812695#ent", "<e1>", ")", "and", "bind", "calcitonin", "gene-related", "peptide", "C1705783#ent", "<e2>", ")", "with", "similar", "affinities", "when", "coexpressed", "with", "RAMP1", "."], "h": {"id": "C3812695", "name": "C3812695#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705783", "name": "C1705783#ent", "pos": [22, 23]}}
{"token": ["C0101202#ent", "<e1>", "than", "acetylsalicylic", "acid-vitamin", "C", "reduced", "C1439341#ent", "<e2>", "expression", "of", "these", "antioxidant", "enzymes"], "h": {"id": "C0101202", "name": "C0101202#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1439341", "name": "C1439341#ent", "pos": [7, 8]}}
{"token": ["We", "constructed", "and", "characterized", "a", "series", "of", "C1335202#ent", "<e1>", "mutants", "which", "contain", "binding", "sites", "C0044602#ent", "<e2>", "well", "as", "one", "additional", "protein", ",", "either", "RasGAP", ",", "SHP-2", ",", "or", "PLC", "gamma"], "h": {"id": "C1335202", "name": "C1335202#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0044602", "name": "C0044602#ent", "pos": [14, 15]}}
{"token": ["Initial", "symptoms", "of", "amyotrophic", "lateral", "sclerosis", "ALS", ")", "may", "mimic", "C0700594#ent", "<e1>", ",", "myelopathy", ",", "mononeuropathy", ",", "or", "C0003892#ent", "<e2>", "."], "h": {"id": "C0700594", "name": "C0700594#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003892", "name": "C0003892#ent", "pos": [18, 19]}}
{"token": ["Intriguingly", ",", "C1538659#ent", "<e1>", "phosphorylation", "inactive", "mutant", "ESE1-S207A", "is", "more", "unstable", "than", "either", "wild-type", "C1706322#ent", "<e2>", "or", "its", "C1538659#ent", "<e1>", "phosphorylation", "mimetic", "mutant", ",", "i.e.", "ESE1-S207E", "."], "h": {"id": "C1706322", "name": "C1706322#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1538659", "name": "C1538659#ent", "pos": [2, 3]}}
{"token": ["The", "Gram-negative", "aerobic", "bacteria", "the", "major", "responsible", "for", "C1705296#ent", "<e1>", "episodes", "and", "C0085426#ent", "<e2>", "mainly", "Staphylococcus", "aureus", "are", "being", "considered", "an", "emergent", "agent", "C1705296#ent", "<e1>", "."], "h": {"id": "C1705296", "name": "C1705296#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0085426", "name": "C0085426#ent", "pos": [12, 13]}}
{"token": ["C0006111#ent", "<e1>", "psychiatric", "and", "C0027765#ent", "<e2>", "represents", "a", "considerable", "social", "and", "economic", "burden", "Europe", "."], "h": {"id": "C0006111", "name": "C0006111#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [4, 5]}}
{"token": ["Three", "of", "the", "five", "genes", "are", "involved", "in", "chromosome", "stabilization", "Pituitary", "tumor", "transforming", "gene", "1", "Pttg1", ",", "Establishment", "of", "cohesion", "1", "homolog", "1", "or", "C1539366#ent", "<e1>", ",", "and", "a", "C0079429#ent", "<e2>", "similar", "to", "histone", "H2B", "."], "h": {"id": "C1539366", "name": "C1539366#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [29, 30]}}
{"token": ["We", "examined", "how", "cells", "transduce", "the", "C1366557#ent", "<e1>", "the", "cell", "surface", "the", "gadd45beta", "genomic", "locus", "and", "describe", "how", "C1414928#ent", "<e2>", "contributes", "to", "TGFbeta", "biology", "."], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1414928", "name": "C1414928#ent", "pos": [18, 19]}}
{"token": ["Last", ",", "SMAD3", "and", "SMAD4", "reconstitution", "in", "SMAD-deficient", "cancer", "cells", "restored", "C1366557#ent", "<e1>", "induction", "of", "C1414928#ent", "<e2>", "."], "h": {"id": "C1366557", "name": "C1366557#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414928", "name": "C1414928#ent", "pos": [15, 16]}}
{"token": ["C3887648#ent", "<e1>", "and", "epinephrine", "concentrations", "in", "plasma", "and", "cerebrospinal", "fluid", "C0031406#ent", "<e2>", "7", "and", "12", "increased", "significantly", "as", "compared", "with", "control", "values", ",", "while", "plasma", "dopamine", "concentration", "increased", "significantly", "on", "C0031406#ent", "<e2>", "7", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031406", "name": "C0031406#ent", "pos": [10, 11]}}
{"token": ["Genome-wide", "association", "studies", "recently", "identified", "a", "locus", "on", "C2736876#ent", "<e1>", "influences", "risk", "of", "C1956346#ent", "<e2>", "CAD", ")", "."], "h": {"id": "C2736876", "name": "C2736876#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [13, 14]}}
{"token": ["The", "present", "studies", "examine", "the", "subcellular", "location", "of", "NHERF-1", "and", "C1705710#ent", "<e1>", "and", "their", "interactions", "with", "target", "proteins", "NHE3", ",", "C1420185#ent", "<e2>", ",", "and", "ezrin", "."], "h": {"id": "C1705710", "name": "C1705710#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420185", "name": "C1420185#ent", "pos": [20, 21]}}
{"token": ["Degradation", "of", "cartilage", "in", "C0949690#ent", "<e1>", "of", "man", "results", "in", "the", "release", "of", "sulphated", "glycosaminoglycans", "particularly", "C0026707#ent", "<e2>", "into", "tissue", "fluids"], "h": {"id": "C0949690", "name": "C0949690#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0026707", "name": "C0026707#ent", "pos": [16, 17]}}
{"token": ["The", "bronchial", "epithelium-dependent", "relaxation", "could", "be", "inhibited", "by", "indomethacin", "but", "not", "be", "blocked", "by", "the", "following", "C0991617#ent", "<e1>", ":", "atropine", ",", "propranolol", ",", "gossypol", ",", "methylene", "blue", "C0008281#ent", "<e2>", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0008281", "name": "C0008281#ent", "pos": [27, 28]}}
{"token": ["Histamine", "H1-receptor", "blocking", "C0991617#ent", "<e1>", "such", "as", "diphenhydramine", ",", "promethazine", "and", "C0008281#ent", "<e2>", "also", "showed", "muricidal", "suppression", ",", "but", "astemizole", "which", "lacks", "central", "effects", "not", "show", "muricidal", "suppression", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008281", "name": "C0008281#ent", "pos": [11, 12]}}
{"token": ["The", "frequency", "of", "asymmetric", "sacroiliitis", "be", "higher", "in", "other", "inflammatory", "disorders", "e.g.", ",", "reactive", "arthritis", "Reiters", "syndrome", "C0038012#ent", "<e1>", "associated", "with", "psoriasis", ",", "or", "C0010346#ent", "<e2>"], "h": {"id": "C0038012", "name": "C0038012#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [24, 25]}}
{"token": ["C3538811#ent", "<e1>", "immunoprecipitated", "from", "stage", "IV", "stage", "VI", "oocytes", "had", "C0059946#ent", "<e2>", "RNA", "helicase", "activity", "."], "h": {"id": "C3538811", "name": "C3538811#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [10, 11]}}
{"token": ["Positive", "associations", "were", "observed", "between", "BMI", "and", "the", "presence", "of", "C0151744#ent", "<e1>", "high", "blood", "pressure", "gout", ",", "arthritis", "and", "C0016977#ent", "<e2>", "not", "with", "diabetes", "mellitus"], "h": {"id": "C0151744", "name": "C0151744#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0016977", "name": "C0016977#ent", "pos": [19, 20]}}
{"token": ["However", ",", "cerulenin", "showed", "a", "marked", "inhibitory", "activity", "to", "the", "C1538973#ent", "<e1>", "if", "the", "reducing", "C0003438#ent", "<e2>", "was", "omitted", "from", "the", "assay", "mixture"], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0003438", "name": "C0003438#ent", "pos": [15, 16]}}
{"token": ["By", "using", "cultured", "keratinocytes", "treated", "with", "and", "-antagonists", ",", "we", "demonstrated", "that", "down-regulation", "of", "C1705124#ent", "<e1>", "is", "mediated", "by", "C1705401#ent", "<e2>", "."], "h": {"id": "C1705124", "name": "C1705124#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1705401", "name": "C1705401#ent", "pos": [19, 20]}}
{"token": ["Components", "of", "grapefruit", "juice", "interfere", "with", "the", "function", "of", "intestinal", "C1142644#ent", "<e1>", "which", "degrades", "C0085173#ent", "<e2>", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [10, 11]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0085173", "name": "C0085173#ent", "pos": [14, 15]}}
{"token": ["Supplementing", "SO", "increased", "C(18:2", ")", "trans-10", ",", "cis-12", "C4283784#ent", "<e1>", "in", "adipose", "tissue", "the", "C1414435#ent", "<e2>", "."], "h": {"id": "C4283784", "name": "C4283784#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414435", "name": "C1414435#ent", "pos": [14, 15]}}
{"token": ["Cysticercosis", "is", "a", "human", "C0030499#ent", "<e1>", ",", "which", "is", "considered", "the", "most", "common", "cause", "of", "C0751495#ent", "<e2>", "worldwide", "."], "h": {"id": "C0030499", "name": "C0030499#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [15, 16]}}
{"token": ["Taenia", "solium", "the", "commonest", "C0030499#ent", "<e1>", "CNS", "and", "an", "important", "cause", "of", "new-onset", "C0751495#ent", "<e2>", "and", "epilepsy", "in", "children", "and", "adults", "."], "h": {"id": "C0030499", "name": "C0030499#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [13, 14]}}
{"token": ["These", "results", "indicate", "that", "the", "reduced", "activity", "of", "SM-12502", "S-oxidase", "and", "no", "activity", "of", "C1828472#ent", "<e1>", "caused", "by", "the", "lack", "of", "C1413868#ent", "<e2>", "mRNA", "and", "CYP2A6", "protein", "by", "the", "CYP2A6", "gene", "deletion"], "h": {"id": "C1828472", "name": "C1828472#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1413868", "name": "C1413868#ent", "pos": [21, 22]}}
{"token": ["These", "results", "demonstrate", "that", "the", "C1705999#ent", "<e1>", "members", "associate", "with", "C1430988#ent", "<e2>"], "h": {"id": "C1705999", "name": "C1705999#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [10, 11]}}
{"token": ["C0221036#ent", "<e1>", "defined", "as", "C0011991#ent", "<e2>", "bile", "acid", "malabsorption", "unknown", "cause", "and", "a", "symptomatic", "response", "to", "cholestyramine", "."], "h": {"id": "C0221036", "name": "C0221036#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [4, 5]}}
{"token": ["This", "study", "was", "undertaken", "to", "examine", "whether", "gamma", "delta", "T", "cells", "from", "cerebrospinal", "fluid", "blood", "of", "C0026269#ent", "<e1>", "patients", "could", "be", "stimulated", "by", "bacterial", "superantigens", "staphylococcal", "enterotoxins", "A", "B", "and", "C0600327#ent", "<e2>"], "h": {"id": "C0026269", "name": "C0026269#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0600327", "name": "C0600327#ent", "pos": [30, 31]}}
{"token": ["Serum", "levels", "of", "complement", "components", "C3", "C4", "and", "C1824728#ent", "<e1>", "measured", "in", "twenty-five", "patients", "with", "C1142423#ent", "<e2>"], "h": {"id": "C1824728", "name": "C1824728#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1142423", "name": "C1142423#ent", "pos": [15, 16]}}
{"token": ["Thus", ",", "cultured", "C3812675#ent", "<e1>", "from", "F-344", "rats", "are", "highly", "responsive", "to", "C1367657#ent", "<e2>", "demonstrate", "age-related", "changes", ",", "but", "undergo", "phenotypic", "modulation", "during", "passage", "."], "h": {"id": "C3812675", "name": "C3812675#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1367657", "name": "C1367657#ent", "pos": [12, 13]}}
{"token": ["Substrate", "hydrolysis", "prevented", "by", "preincubating", "the", "cells", "with", "C0056236#ent", "<e1>", "CBE", ")", ",", "a", "specific", "active", "site-directed", "inhibitor", "of", "C1425933#ent", "<e2>"], "h": {"id": "C0056236", "name": "C0056236#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1425933", "name": "C1425933#ent", "pos": [19, 20]}}
{"token": ["Our", "data", "suggest", "that", "C1417760#ent", "<e1>", "is", "induced", "through", "IFNAR1", "and", "C1706299#ent", "<e2>", "in", "Mac3-positive", "cells", "which", "are", "the", "main", "source", "of", "C1417760#ent", "<e1>", "in", "spleen", "and", "lung", "."], "h": {"id": "C1706299", "name": "C1706299#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [4, 5]}}
{"token": ["Macrophages", "deficient", "IFNalphabeta", "receptor", "chain", "1", "(", "IFNAR1", ")", "or", "C1706299#ent", "<e1>", "were", "shown", "to", "have", "an", "impaired", "LPS-induced", "C1417760#ent", "<e2>", "expression", "."], "h": {"id": "C1706299", "name": "C1706299#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417760", "name": "C1417760#ent", "pos": [19, 20]}}
{"token": ["Therefore", ",", "based", "on", "isotype", "specificity", "and", "antitumor", "activity", "C1566319#ent", "<e1>", "and", "SK-7068", "HDAC", "inhibitors", "expected", "to", "be", "promising", "C0003392#ent", "<e2>", "therapeutic", "agents", "need", "additional", "clinical", "development"], "h": {"id": "C1566319", "name": "C1566319#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [19, 20]}}
{"token": ["The", "introduction", "of", "an", "C0054666#ent", "<e1>", "link", "between", "the", "ring", "and", "the", "ethanolamine", "side", "chain", "some", "C0001644#ent", "<e2>", "compounds", "with", "beta", "1-receptor", "stimulant", "actions", "coupled", "with", "weak", "beta-receptor", "antagonistic", "activity"], "h": {"id": "C0054666", "name": "C0054666#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001644", "name": "C0001644#ent", "pos": [16, 17]}}
{"token": ["No", "clinical", "manifestations", "C0002986#ent", "<e1>", "observed", "except", "for", "C0020620#ent", "<e2>", "and", "angiokeratoma", "."], "h": {"id": "C0002986", "name": "C0002986#ent", "pos": [3, 4]}, "relation": "has_manifestation", "t": {"id": "C0020620", "name": "C0020620#ent", "pos": [8, 9]}}
{"token": ["In", "conclusion", ",", "reKT", "represents", "an", "effective", "treatment", "option", "in", "SPK", "patients", "with", "C0022660#ent", "<e1>", "account", "of", "C1414170#ent", "<e2>", "."], "h": {"id": "C0022660", "name": "C0022660#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1414170", "name": "C1414170#ent", "pos": [17, 18]}}
{"token": ["Tamoxifen-induced", "C0069197#ent", "<e1>", "degradation", "could", "be", "blocked", "by", "MG-132", ",", "a", "C1443643#ent", "<e2>"], "h": {"id": "C0069197", "name": "C0069197#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1443643", "name": "C1443643#ent", "pos": [11, 12]}}
{"token": ["It", "is", "concluded", "that", "C0072495#ent", "<e1>", "has", "an", "inhibitory", "activity", "on", "platelet", "aggregation", "activates", "C0001492#ent", "<e2>", "increases", "cyclic", "AMP", "content", "in", "platelets", ",", "in", "addition", "to", "other", "inhibitory", "actions", "in", "the", "metabolic", "system", "cyclic", "AMP"], "h": {"id": "C0072495", "name": "C0072495#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001492", "name": "C0001492#ent", "pos": [14, 15]}}
{"token": ["Coadministration", "of", "C0038792#ent", "<e1>", "sulfide", "and", "the", "small-molecule", "C4086018#ent", "<e2>", "-", "1", "increased", "apoptosis", "induction", "and", "enhanced", "caspase-8", "and", "caspase-9", "cleavage", "Bax", "redistribution", ",", "and", "cytochrome", "c", "second", "mitochondria-derived", "activator", "of", "caspase", "release", "."], "h": {"id": "C0038792", "name": "C0038792#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4086018", "name": "C4086018#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "recombinant", "NP2", ",", "but", "not", "recombinant", "C1334905#ent", "<e1>", "or", "NP4", ",", "is", "a", "potent", "C3536711#ent", "<e2>", ";", "recombinant", "NP3", "also", "displays", "minor", "activity", "."], "h": {"id": "C1334905", "name": "C1334905#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3536711", "name": "C3536711#ent", "pos": [19, 20]}}
{"token": ["Because", "72-kD", "tyrosine", "kinase", "was", "distinct", "from", "C1706351#ent", "<e1>", ",", "Tec", ",", "and", "C1528376#ent", "<e2>", "and", "coimmunoprecipitated", "with", "anti-Stat", "antiserum", ",", "we", "termed", "it", "Stat-associated", "72-kD", "tyrosine", "kinase", "(", "p72sak", ")", "."], "h": {"id": "C1706351", "name": "C1706351#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1528376", "name": "C1528376#ent", "pos": [13, 14]}}
{"token": ["The", "initial", "sign", "C0013428#ent", "<e1>", "followed", "by", "diarrhea", ",", "melena", ",", "and", "C4019039#ent", "<e2>", "."], "h": {"id": "C0013428", "name": "C0013428#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4019039", "name": "C4019039#ent", "pos": [12, 13]}}
{"token": ["This", "suggests", "that", "dihydrogenated", "ergot", "compounds", ",", "especially", "C0014708#ent", "<e1>", ",", "possess", "appreciable", "binding", "activity", "comparable", "to", "that", "of", "C4048284#ent", "<e2>", "and", "barbiturates", ")", "at", "the", "GABAA", "receptor-associated", "C1-", "ionophore", "."], "h": {"id": "C0014708", "name": "C0014708#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [19, 20]}}
{"token": ["From", "the", "sequence", "analysis", "we", "found", "that", "the", "C1424865#ent", "<e1>", "gene", "product", "one", "of", "a", "group", "of", "C0086376#ent", "<e2>", "that", "share", "multiple", "zinc", "finger", "motifs", "and", "an", "adjacent", "leucine", "zipper", "motif"], "h": {"id": "C1424865", "name": "C1424865#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [17, 18]}}
{"token": ["Escherichia", "coil", "signal", "peptidase", "I", "(", "C0142292#ent", "<e1>", "SPase", "I", "is", "an", "C1622401#ent", "<e2>", "catalyzes", "the", "cleavage", "of", "signal", "(", "leader", ")", "peptides", "from", "pre-forms", "of", "membrane", "or", "secretory", "proteins"], "h": {"id": "C0142292", "name": "C0142292#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1622401", "name": "C1622401#ent", "pos": [12, 13]}}
{"token": ["The", "results", "suggest", "that", "C1422161#ent", "<e1>", "is", "responsible", "for", "proteolytic", "removal", "of", "the", "C-terminal", "aaX", "C0769557#ent", "<e2>", "these", "parasites", "."], "h": {"id": "C1422161", "name": "C1422161#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0769557", "name": "C0769557#ent", "pos": [15, 16]}}
{"token": ["Their", "adverse", "effects", "include", "gastric", "distress", "possibly", "hemorrhage", ")", ",", "C0042109#ent", "<e1>", "bronchospasm", "in", "asthma", "patients", ",", "C0242528#ent", "<e2>", ",", "arrested", "labor", "skin", "reactions", "and", "water", "retention"], "h": {"id": "C0042109", "name": "C0042109#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242528", "name": "C0242528#ent", "pos": [17, 18]}}
{"token": ["C0282221#ent", "<e1>", ",", "a", "mu", "opioid", "receptor", "agonist", "which", "is", "commonly", "used", "as", "an", "C0011991#ent", "<e2>", "been", "reported", "to", "possess", "analgesic", "activity", "intrathecal", "administration"], "h": {"id": "C0282221", "name": "C0282221#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [14, 15]}}
{"token": ["Fungal", "phytases", "belonging", "to", "\"", "C0001109#ent", "<e1>", "or", "HAP", "class", "of", "C0031678#ent", "<e2>", "that", "catalyze", "the", "hydrolysis", "of", "phytic", "acid", "also", "hydrolyze", "O-phospho-L-tyrosine", ",", "which", "is", "also", "called", "phosphotyrosine", "."], "h": {"id": "C0001109", "name": "C0001109#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031678", "name": "C0031678#ent", "pos": [11, 12]}}
{"token": ["Treatment", "of", "C0038054#ent", "<e1>", "folate", "and", "B(12", ")", "cures", "the", "C1420653#ent", "<e2>", "the", "accompanying", "glossitis", ",", "and", "often", "results", "in", "increased", "appetite", "and", "weight", "gain"], "h": {"id": "C0038054", "name": "C0038054#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420653", "name": "C1420653#ent", "pos": [10, 11]}}
{"token": ["CYP2C8", "and", "C1142644#ent", "<e1>", "are", "the", "major", "enzymes", "responsible", "for", "the", "metabolism", "of", "C0724549#ent", "<e2>", ",", "and", "a", "transporter", ",", "OATP2", ",", "contributes", "to", "uptake", "of", "C0724549#ent", "<e2>", "to", "the", "liver", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [2, 3]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0724549", "name": "C0724549#ent", "pos": [13, 14]}}
{"token": ["To", "determine", "the", "effects", "of", "itraconazole", ",", "a", "potent", "inhibitor", "of", "C1142644#ent", "<e1>", ",", "on", "the", "pharmacokinetics", "of", "C0724549#ent", "<e2>", ",", "a", "competitive", "3-hydroxy-3-methylglutaryl", "coenzyme", "A", "HMG-CoA", ")", "reductase", "inhibitor", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [11, 12]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0724549", "name": "C0724549#ent", "pos": [18, 19]}}
{"token": ["424:516", "-", "523", ")", "have", "shown", "that", "C1705526#ent", "<e1>", "is", "also", "induced", "in", "response", "to", "C0162628#ent", "<e2>", "a", "downstream", "transcriptional", "target", "of", "type", "I", "interferon", "IFN", ")", "signaling", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0162628", "name": "C0162628#ent", "pos": [15, 16]}}
{"token": ["Soluble", "enzymes", ",", "extracted", "from", "bovine", "retinal", "rod", "outer", "segments", "ROS", ")", ",", "were", "recombined", "with", "native", "ROS", "discs", "and", "discs", "which", "had", "been", "modified", "either", "by", "C0030946#ent", "<e1>", "treatment", "or", "phosphorylation", "with", "C1384522#ent", "<e2>"], "h": {"id": "C0030946", "name": "C0030946#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C1384522", "name": "C1384522#ent", "pos": [33, 34]}}
{"token": ["Confirmation", "was", "established", "of", "the", "connection", "between", "the", "development", "of", "atrial", "tachycardia", "C0151517#ent", "<e1>", "changes", "in", "the", "myocardium", ",", "circulatory", "insufficiency", "C0022660#ent", "<e2>", "toxicosis", "with", "cardiac", "glucosides"], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [21, 22]}}
{"token": ["To", "explore", "the", "physiological", "roles", "of", "two", "major", "regulatory", "isoforms", "p85", "alpha", "C1423080#ent", "<e1>", "we", "have", "established", "brown", "adipose", "cell", "lines", "disruption", "of", "the", "Pik3r1", "or", "C3541313#ent", "<e2>"], "h": {"id": "C1423080", "name": "C1423080#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3541313", "name": "C3541313#ent", "pos": [26, 27]}}
{"token": ["D-RNAs", "expressing", "the", "C1413138#ent", "<e1>", "demonstrated", "to", "be", "capable", "of", "producing", "C0007367#ent", "<e2>", "a", "helper-dependent", "expression", "system", "to", "about", "1.6", "microgram", "per", "10(6", ")", "cells", "."], "h": {"id": "C1413138", "name": "C1413138#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0007367", "name": "C0007367#ent", "pos": [11, 12]}}
{"token": ["The", "fluoroquinolones", "in", "general", ",", "and", "particularly", "C0008806#ent", "<e1>", ",", "show", "great", "promise", "in", "the", "treatment", "of", "C0042029#ent", "<e2>"], "h": {"id": "C0008806", "name": "C0008806#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [17, 18]}}
{"token": ["These", "findings", "have", "important", "implications", "for", "any", "control", "programme", "for", "diseases", "that", "can", "be", "spread", "by", "the", "same", "routes", "as", "C0242338#ent", "<e1>", "the", "human", "immunodeficiency", "viruses", "hepatitis", "B", "and", "C0814152#ent", "<e2>", "."], "h": {"id": "C0242338", "name": "C0242338#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0814152", "name": "C0814152#ent", "pos": [29, 30]}}
{"token": ["A", "clone", "containing", "the", "C1334084#ent", "<e1>", "the", "second", "chain", "IFN-gamma", "R2", "of", "the", "C1334083#ent", "<e2>", "isolated", "from", "a", "cosmid", "library", "of", "129/Sv", "mouse", "genomic", "DNA"], "h": {"id": "C1334084", "name": "C1334084#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334083", "name": "C1334083#ent", "pos": [13, 14]}}
{"token": ["Mdm-2", ",", "a", "C1421688#ent", "<e1>", "negatively", "regulates", "the", "C0079419#ent", "<e2>", "binding", "to", "it", "and", "preventing", "transcriptional", "activation", "16", ")", "."], "h": {"id": "C1421688", "name": "C1421688#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0079419", "name": "C0079419#ent", "pos": [8, 9]}}
{"token": ["Ectopic", "expression", "of", "USF1", "or", "USF2", "enhanced", "C1418569#ent", "<e1>", "promoter", "activity", "while", "exogenous", "C0079068#ent", "<e2>", "did", "not", "."], "h": {"id": "C1418569", "name": "C1418569#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0079068", "name": "C0079068#ent", "pos": [13, 14]}}
{"token": ["It", "was", "investigated", "in", "rats", "whether", "chronic", "administration", "C0005632#ent", "<e1>", "reduces", "the", "effects", "of", "acute", "bisacodyl", "administration", "on", "net", "water", "C3536863#ent", "<e2>", "flux", "in", "the", "rat", "colon", "transport", "in-vivo", "."], "h": {"id": "C0005632", "name": "C0005632#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3536863", "name": "C3536863#ent", "pos": [20, 21]}}
{"token": ["Deletion", "of", "a", "loop", "unique", "to", "C1434268#ent", "<e1>", "eliminated", "its", "activation", "by", "RhoA", "but", "not", "C1705572#ent", "<e2>", "."], "h": {"id": "C1434268", "name": "C1434268#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [15, 16]}}
{"token": ["DNA", "rearrangement", "IRF-1", "was", "detected", "in", "C3538705#ent", "<e1>", "and", "PLC/PRF/5", "by", "Southern", "blotting", "while", "C1708450#ent", "<e2>", "preserved", "."], "h": {"id": "C3538705", "name": "C3538705#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1708450", "name": "C1708450#ent", "pos": [14, 15]}}
{"token": ["A", "magnetic", "resonance", "imaging", "was", "initially", "requested", "to", "exclude", "C0003869#ent", "<e1>", "and", "demonstrated", "a", "joint", "effusion", "C1739148#ent", "<e2>", ",", "and", "a", "2-cm", "linear", "opacity", "in", "the", "synovium", "."], "h": {"id": "C0003869", "name": "C0003869#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1739148", "name": "C1739148#ent", "pos": [16, 17]}}
{"token": ["C0020455#ent", "<e1>", "found", "in", "90", "%", "of", "patients", "and", "C1262202#ent", "<e2>", "80", "%", "."], "h": {"id": "C0020455", "name": "C0020455#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1262202", "name": "C1262202#ent", "pos": [9, 10]}}
{"token": ["However", ",", "C0887621#ent", "<e1>", "may", "induce", "adverse", "effects", "infants", "(", "C0036572#ent", "<e2>", "or", "cardiac", "arrhythmias", ",", "likely", "because", "of", "decreased", "hepatic", "clearance", "and", "serum", "protein", "binding", "."], "h": {"id": "C0887621", "name": "C0887621#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [10, 11]}}
{"token": ["The", "ISM1", "gene", "C1825559#ent", "<e1>", "been", "localized", "to", "chromosome", "XVI", "next", "to", "C1708004#ent", "<e2>", "."], "h": {"id": "C1825559", "name": "C1825559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1708004", "name": "C1708004#ent", "pos": [12, 13]}}
{"token": ["In", "our", "previous", "study", "we", "demonstrated", "that", "presenilin", "1", "C2986918#ent", "<e1>", ")", "interacts", "with", "C1824746#ent", "<e2>", "CLIP-170/Restin", ")", "."], "h": {"id": "C2986918", "name": "C2986918#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1824746", "name": "C1824746#ent", "pos": [14, 15]}}
{"token": ["Bridges", "(", "1916", ")", "observed", "that", "X", "chromosome", "nondisjunction", "much", "more", "frequent", "in", "C2827598#ent", "<e1>", "females", "than", "it", "was", "in", "C1516876#ent", "<e2>", "normal", "XX", "females", "."], "h": {"id": "C2827598", "name": "C2827598#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [20, 21]}}
{"token": ["Finally", ",", "NRP1", "expression", "and", "its", "C0017346#ent", "<e1>", "modification", "post-transcriptionally", "regulate", "C1334306#ent", "<e2>", "expression", "."], "h": {"id": "C0017346", "name": "C0017346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334306", "name": "C1334306#ent", "pos": [11, 12]}}
{"token": ["The", "mutant", "shows", "markedly", "reduced", "activity", "of", "C0039850#ent", "<e1>", "EC", "2.7.6.2", ")", "and", "high", "resistance", "C0030093#ent", "<e2>", ",", "a", "thiamine", "antagonist", "whose", "potency", "depends", "on", "C0039850#ent", "<e1>", "activity", "."], "h": {"id": "C0039850", "name": "C0039850#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0030093", "name": "C0030093#ent", "pos": [15, 16]}}
{"token": ["However", ",", "the", "incomplete", "overlap", "with", "a", "neural", "crest", "marker", "C1420317#ent", "<e1>", ",", "suggests", "that", "C1417167#ent", "<e2>", "is", "a", "marker", "for", "somitomeric", "mesoderm", "and", "potentially", "for", "a", "subset", "of", "neural", "crest", "cells"], "h": {"id": "C1420317", "name": "C1420317#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417167", "name": "C1417167#ent", "pos": [15, 16]}}
{"token": ["We", "used", "a", "repressible", "promoter", "fused", "to", "the", "C1332721#ent", "<e1>", "cDNA", "to", "C1875400#ent", "<e2>", "conditionally", "dominant", "negative", "mutants", "of", "C1332721#ent", "<e1>", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1332721", "name": "C1332721#ent", "pos": [8, 9]}}
{"token": ["It", "is", "concluded", "that", "placebo", "suspension", "has", "a", "considerable", "effect", "on", "C0017168#ent", "<e1>", "symptoms", ",", "but", "C0008783#ent", "<e2>", "suspension", "provides", "significantly", "better", "relief", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0008783", "name": "C0008783#ent", "pos": [16, 17]}}
{"token": ["The", "activation", "of", "C0257535#ent", "<e1>", "Galpha(q", ")", "and", "Gbetagamma", "was", "blocked", "by", "C1453853#ent", "<e2>", "MKK3", "and", "MKK6", "but", "not", "by", "kinase-deficient", "MKK4", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1453853", "name": "C1453853#ent", "pos": [12, 13]}}
{"token": ["Imipramine", "hydrochloride", "IPH", ")", "and", "C0700529#ent", "<e1>", "DPH", ")", ",", "two", "widely", "used", "C0003289#ent", "<e2>", "are", "proposed", "as", "new", "reagents", "for", "detection", "of", "faecal", "occult", "blood"], "h": {"id": "C0700529", "name": "C0700529#ent", "pos": [5, 6]}, "relation": "has_therapeutic_class", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [13, 14]}}
{"token": ["Only", "15", "%", "of", "the", "AML", "samples", "were", "\"", "intermediately", "\"", "sensitive", "to", "C3540778#ent", "<e1>", ",", "mainly", "in", "C2828027#ent", "<e2>", "M1/M2", "."], "h": {"id": "C3540778", "name": "C3540778#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2828027", "name": "C2828027#ent", "pos": [18, 19]}}
{"token": ["Similar", "C1522575#ent", "<e1>", "mRNA", "accumulation", "was", "observed", "also", "with", "C1706260#ent", "<e2>", ",", "another", "chemical", "NO", "generator", "."], "h": {"id": "C1522575", "name": "C1522575#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706260", "name": "C1706260#ent", "pos": [9, 10]}}
{"token": ["Here", "we", "show", "that", "those", "Ets", "family", "proteins", "participate", "in", "Ewing's", "sarcoma", "including", "C0808900#ent", "<e1>", ",", "ERG", ",", "and", "C1333361#ent", "<e2>", ",", "cooperatively", "bind", "these", "tandem", "elements", "Fos-Jun", "while", "other", "Ets", "family", "members", "not", "."], "h": {"id": "C0808900", "name": "C0808900#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1333361", "name": "C1333361#ent", "pos": [19, 20]}}
{"token": ["C0004743#ent", "<e1>", "induces", "all", "these", "C1417679#ent", "<e2>", "in", "all", "three", "strains", "and", "increases", "the", "levels", "of", "the", "two", "Cyp6a8", "transcripts", "and", "the", "1.8-kb", "RNA", "produced", "by", "the", "Cyp6a9", "and/or", "Cyp6a9-related", "genes", "."], "h": {"id": "C0004743", "name": "C0004743#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [5, 6]}}
{"token": ["Finally", ",", "the", "affects", "of", "other", "C1136365#ent", "<e1>", "such", "as", "C0359916#ent", "<e2>", ",", "are", "discussed", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0359916", "name": "C0359916#ent", "pos": [10, 11]}}
{"token": ["There", "was", "no", "difference", "between", "the", "groups", "in", "the", "plasma", "levels", ",", "which", "were", "within", "the", "recognized", "C0003195#ent", "<e1>", "range", "for", "C0016229#ent", "<e2>", "(", "200", "to", "1000", "ng/ml", ")", "throughout", "the", "infusion", "."], "h": {"id": "C0003195", "name": "C0003195#ent", "pos": [17, 18]}, "relation": "therapeutic_class_of", "t": {"id": "C0016229", "name": "C0016229#ent", "pos": [21, 22]}}
{"token": ["They", "have", "congenital", "complete", "insensitivity", "to", "C3536949#ent", "<e1>", "due", "to", "an", "C0678928#ent", "<e2>"], "h": {"id": "C3536949", "name": "C3536949#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0678928", "name": "C0678928#ent", "pos": [11, 12]}}
{"token": ["Tumor", "necrosis", "factor", "receptor-1", "TNFR-1", ")", "and", "CD95", "(", "also", "called", "C0015923#ent", "<e1>", "or", "APO-1", ")", "are", "C1333197#ent", "<e2>", "engage", "the", "apoptosis", "pathway", "through", "a", "region", "of", "intracellular", "homology", ",", "designated", "the", "\"", "death", "domain"], "h": {"id": "C0015923", "name": "C0015923#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1333197", "name": "C1333197#ent", "pos": [17, 18]}}
{"token": ["In", "this", "study", ",", "the", "levels", "of", "C1522428#ent", "<e1>", "IL-1", "beta", "were", "measured", "in", "pleural", "fluid", "patients", "with", "C0080032#ent", "<e2>", "before", "and", "during", "quinacrine-induced", "pleurodesis", "."], "h": {"id": "C1522428", "name": "C1522428#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0080032", "name": "C0080032#ent", "pos": [18, 19]}}
{"token": ["Escherichia", "coli", "recombinant", "cells", "were", "immobilized", "by", "entrapment", "in", "a", "carrageenan", "gel", "cultivated", "in", "nonselective", "media", "to", "investigate", "the", "effect", "of", "C0085631#ent", "<e1>", "plasmid", "stability", ",", "biomass", "concentration", ",", "and", "C0014442#ent", "<e2>", "productivity", "."], "h": {"id": "C0085631", "name": "C0085631#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [30, 31]}}
{"token": ["The", "rat", "creatine", "kinase", "B", "C3714613#ent", "<e1>", ")", "gene", "is", "induced", "by", "C2936882#ent", "<e2>", "in", "the", "uterus", ",", "and", "constructs", "containing", "rat", "CKB", "gene", "inserts", "are", "highly", "estrogen-responsive", "in", "cell", "culture"], "h": {"id": "C3714613", "name": "C3714613#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2936882", "name": "C2936882#ent", "pos": [12, 13]}}
{"token": ["Propylthiouracil", "(", "PTU", ")", "has", "recently", "been", "observed", "to", "be", "associated", "with", "antineutrophil", "cytoplasmic", "antibody", "C0151436#ent", "<e1>", "resulting", "in", "crescentic", "glomerulonephritis", ",", "infrequently", ",", "C0852879#ent", "<e2>", "DAH", ")", "."], "h": {"id": "C0151436", "name": "C0151436#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0852879", "name": "C0852879#ent", "pos": [24, 25]}}
{"token": ["Eleven", "individuals", "with", "a", "normal", "C1706333#ent", "<e1>", "and", "8", "patients", "with", "a", "C0277565#ent", "<e2>", "C1706333#ent", "<e1>", "underwent", "MR", "imaging"], "h": {"id": "C1706333", "name": "C1706333#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [12, 13]}}
{"token": ["Consideration", "is", "given", "to", "the", "biological", "reasons", "the", "considerable", "polymorphism", "in", "the", "numbers", "of", "repeats", "in", "C1539099#ent", "<e1>", ",", "but", "not", "C1332707#ent", "<e2>", "."], "h": {"id": "C1539099", "name": "C1539099#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1332707", "name": "C1332707#ent", "pos": [21, 22]}}
{"token": ["The", "results", "show", "that", "the", "central", "effects", "systemically", "administered", "adenosine", "analogs", "are", "altered", "by", "procedures", "that", "disrupt", "the", "normal", "C0007681#ent", "<e1>", "effect", "of", "C3543842#ent", "<e2>", "noradrenergic", "input", "."], "h": {"id": "C0007681", "name": "C0007681#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [23, 24]}}
{"token": ["CoAM", "functionally", "inhibits", "C1422492#ent", "<e1>", ",", "and", "their", "switched", "expression", "up-regulates", "differentiation", "marker", "C1424266#ent", "<e2>", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1424266", "name": "C1424266#ent", "pos": [13, 14]}}
{"token": ["The", "in", "vivo", "of", "amantadine", ",", "C0008286#ent", "<e1>", "and", "reserpine", "on", "C0684287#ent", "<e2>", "T-ALDH", ")", "was", "studied", "as", "a", "function", "of", "mouse", "strain"], "h": {"id": "C0008286", "name": "C0008286#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0684287", "name": "C0684287#ent", "pos": [11, 12]}}
{"token": ["The", "radiographs", "of", "393", "coal-cutters", "(", "or", "hewers", ")", "and", "187", "drillers", "were", "read", "independently", "by", "two", "C0032273#ent", "<e1>", "experts", "following", "the", "complete", "12", "grade", "classification", "C1705300#ent", "<e2>", "1980", ")", "."], "h": {"id": "C0032273", "name": "C0032273#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1705300", "name": "C1705300#ent", "pos": [26, 27]}}
{"token": ["Here", ",", "we", "show", "that", "absence", "of", "the", "C3540808#ent", "<e1>", "gene", "product", "reduces", "plasma", "triglycerides", "reduces", "weight", "gain", "severely", "hyperlipidemic", "C1366529#ent", "<e2>", "mice", "challenged", "with", "a", "Western", "diet"], "h": {"id": "C3540808", "name": "C3540808#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1366529", "name": "C1366529#ent", "pos": [20, 21]}}
{"token": ["Piceatannol", "inhibited", "NF-kappaB", "in", "cells", "with", "deleted", "C1335892#ent", "<e1>", ",", "indicating", "the", "lack", "of", "involvement", "of", "this", "C0211705#ent", "<e2>", "."], "h": {"id": "C1335892", "name": "C1335892#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [17, 18]}}
{"token": ["To", "specifically", "inhibit", "the", "proliferation", "of", "leukemic", "cells", "the", "C1332085#ent", "<e1>", "we", "constructed", "two", "hammerhead", "ribozymes", "against", "C1851466#ent", "<e2>", "."], "h": {"id": "C1332085", "name": "C1332085#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1851466", "name": "C1851466#ent", "pos": [17, 18]}}
{"token": ["This", "report", "describes", "two", "patients", "in", "whom", "essential", "IgG-IgM", "C0010403#ent", "<e1>", "EMC", ")", "glomerulonephritis", "led", "to", "C2316810#ent", "<e2>"], "h": {"id": "C0010403", "name": "C0010403#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2316810", "name": "C2316810#ent", "pos": [16, 17]}}
{"token": ["Connective", "tissue", "growth", "factor", "CTGF", ")", "is", "a", "novel", ",", "C1420342#ent", "<e1>", "which", "is", "implicated", "in", "fibrotic", "disorders", "C0004153#ent", "<e2>", "."], "h": {"id": "C1420342", "name": "C1420342#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [18, 19]}}
{"token": ["Major", "C0019079#ent", "<e1>", "is", "a", "potentially", "life-threatening", "complication", "of", "cystic", "fibrosis", "CF", ")", "C0034049#ent", "<e2>"], "h": {"id": "C0019079", "name": "C0019079#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0034049", "name": "C0034049#ent", "pos": [13, 14]}}
{"token": ["The", "reported", "success", "of", "heterotopic", "parathyroid", "autotransplantation", "C1367469#ent", "<e1>", ")", "in", "patients", "with", "C0221002#ent", "<e2>", "from", "20", "%", "to", "60", "%", "."], "h": {"id": "C1367469", "name": "C1367469#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0221002", "name": "C0221002#ent", "pos": [13, 14]}}
{"token": ["We", "conclude", "that", "fetal", "growth", "restriction", "late", "in", "nephrogenesis", "can", "lead", "to", "a", "marked", "reduction", "in", "C0722058#ent", "<e1>", "endowment", "but", "does", "not", "affect", "renal", "corpuscle", "macula", "densa", "size", "or", "C0034677#ent", "<e2>", "expression", "."], "h": {"id": "C0722058", "name": "C0722058#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0034677", "name": "C0034677#ent", "pos": [29, 30]}}
{"token": ["With", "potent", "C0012544#ent", "<e1>", ",", "such", "as", "C0257685#ent", "<e2>", "it", "may", "be", "possible", "to", "maintain", "efficacy", "with", "relatively", "infrequent", "administration", "."], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [2, 3]}, "relation": "chemical_structure_of", "t": {"id": "C0257685", "name": "C0257685#ent", "pos": [7, 8]}}
{"token": ["In", "conclusion", ",", "CCL27", "and", "C1705083#ent", "<e1>", "interaction", "is", "important", "for", "the", "development", "of", "C3875321#ent", "<e2>", "our", "AD", "model", "."], "h": {"id": "C1705083", "name": "C1705083#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3875321", "name": "C3875321#ent", "pos": [14, 15]}}
{"token": ["To", "prevent", "the", "cicatrization", "of", "filtering", "blebs", "glaucoma", "filtering", "surgery", "subconjunctival", "injections", "of", "low", "dosage", "C0018606#ent", "<e1>", "were", "administered", "to", "22", "glaucomatous", "C0235267#ent", "<e2>", "(", "20", "patients", ")", "postoperatively", "."], "h": {"id": "C0018606", "name": "C0018606#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0235267", "name": "C0235267#ent", "pos": [22, 23]}}
{"token": ["C1428918#ent", "<e1>", "if", "borne", "by", "appropriate", "strains", "was", "also", "C0040663#ent", "<e2>", "by", "the", "virulent", "phage", "A25", "."], "h": {"id": "C1428918", "name": "C1428918#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0040663", "name": "C0040663#ent", "pos": [9, 10]}}
{"token": ["Protein-protein", "interactions", "Gbetagamma", "and", "C1335829#ent", "<e1>", "are", "inhibited", "by", "the", "C0120466#ent", "<e2>", "Gi3", ",", "suggesting", "that", "C1335829#ent", "<e1>", "can", "bind", "only", "free", "Gbetagamma", "."], "h": {"id": "C1335829", "name": "C1335829#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0120466", "name": "C0120466#ent", "pos": [10, 11]}}
{"token": ["DA-depleted", "rats", "exhibited", "severe", "deficits", "in", "the", "operant", "C0310298#ent", "<e1>", ",", "among", "which", "the", "inability", "to", "perform", "the", "C0310298#ent", "<e1>", "was", "not", "alleviated", "by", "C1705443#ent", "<e1>", "HFS", "."], "h": {"id": "C0310298", "name": "C0310298#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1705443", "name": "C1705443#ent", "pos": [24, 25]}}
{"token": ["Here", "we", "describe", "the", "first", "example", "of", "2", "nm", "gold", "nanoparticles", "(", "Au", "C1836075#ent", "<e1>", ")", "covalently", "functionalized", "with", "a", "C4055261#ent", "<e2>", "paclitaxel", "."], "h": {"id": "C1836075", "name": "C1836075#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4055261", "name": "C4055261#ent", "pos": [20, 21]}}
{"token": ["C0010927#ent", "<e1>", "was", "induced", "in", "guinea", "pigs", "by", "infusing", "Staphylococcus", "aureus", "C1825840#ent", "<e2>", ")", "isolated", "from", "blood", "cultures", "patients", "with", "C0010927#ent", "<e1>", "(", "DIC-SA", ")", "or", "without", "C0010927#ent", "<e1>", "(", "non-DIC-SA", ")", "."], "h": {"id": "C0010927", "name": "C0010927#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1825840", "name": "C1825840#ent", "pos": [11, 12]}}
{"token": ["C0850666#ent", "<e1>", "induces", "a", "biased", "T", "helper", "type", "1", "C1423842#ent", "<e2>", ")", "response", "that", "produces", "IFN-gamma", "and", "Fas", "ligand", "FasL", ")", "."], "h": {"id": "C0850666", "name": "C0850666#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1423842", "name": "C1423842#ent", "pos": [9, 10]}}
{"token": ["Our", "objective", "was", "to", "examine", "the", "influence", "of", "C1142644#ent", "<e1>", "induction", "on", "cholestanol", "elimination", "in", "C0010583#ent", "<e2>", "patients", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [8, 9]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [15, 16]}}
{"token": ["We", "used", "Nav1.8-Cre", "mice", "to", "delete", "C1419861#ent", "<e1>", "in", "nociceptors", "at", "C1417775#ent", "<e2>", "and", "NFH-Cre", "mice", "to", "delete", "C1419861#ent", "<e1>", "throughout", "the", "nervous", "system", "postnatally", "."], "h": {"id": "C1419861", "name": "C1419861#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417775", "name": "C1417775#ent", "pos": [11, 12]}}
{"token": ["At", "the", "dose", "corresponding", "to", "its", "content", "in", "ethyl", "acetate", "extract", ",", "C0075810#ent", "<e1>", "IIA-treatment", "increased", "mouse", "liver", "microsomal", "C0171552#ent", "<e2>", "activity", "."], "h": {"id": "C0075810", "name": "C0075810#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0171552", "name": "C0171552#ent", "pos": [19, 20]}}
{"token": ["To", "detect", "another", "modifying", "genetic", "factor", "C0752124#ent", "<e1>", ",", "we", "studied", "polymorphisms", "in", "the", "C1417679#ent", "<e2>", "for", "interleukin", "(IL)-1beta", "tumor", "necrosis", "factor", "122", "Japanese", "patients", "with", "C0752124#ent", "<e1>", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0752124", "name": "C0752124#ent", "pos": [6, 7]}}
{"token": ["C0037501#ent", "<e1>", "(", "DCA", ")", "infusion", "activates", "muscle", "pyruvate", "dehydrogenase", "complex", "C0309720#ent", "<e2>", ")", "at", "rest", ",", "reducing", "inertia", "in", "mitochondrial", "energy", "delivery", "the", "onset", "of", "exercise", "and", "diminishing", "anaerobic", "energy", "production", "."], "h": {"id": "C0037501", "name": "C0037501#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0309720", "name": "C0309720#ent", "pos": [11, 12]}}
{"token": ["We", "identified", "2", "patients", "who", "presented", "with", "clinical", "features", "consistent", "with", "C2700553#ent", "<e1>", "had", "no", "mutations", "in", "RAG", "or", "C1425020#ent", "<e2>", "."], "h": {"id": "C2700553", "name": "C2700553#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C1425020", "name": "C1425020#ent", "pos": [19, 20]}}
{"token": ["Intriguingly", ",", "among", "FRG1P-associated", "proteins", "are", "SMN", "and", "C1418237#ent", "<e1>", ",", "both", "being", "involved", "in", "C0027868#ent", "<e2>", "possibly", "through", "RNA", "biogenesis-related", "processes", "."], "h": {"id": "C1418237", "name": "C1418237#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027868", "name": "C0027868#ent", "pos": [15, 16]}}
{"token": ["Estradiol", "benzoate", "EB", ")", ",", "a", "C3254086#ent", "<e1>", "was", "injected", "to", "C2004456#ent", "<e2>", "rats", ",", "and", "the", "reversibility", "of", "the", "lesion", "was", "investigated", "."], "h": {"id": "C3254086", "name": "C3254086#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2004456", "name": "C2004456#ent", "pos": [11, 12]}}
{"token": ["Treatment", "of", "rats", "with", "human", "chorionic", "gonadotropin", "hCG", ")", "resulted", "in", "elevated", "levels", "of", "microsomal", "heme", "C0051169#ent", "<e1>", "increased", "activity", "of", "C0876231#ent", "<e2>", "ALA", ")", "synthase", "(", "EC", "2.3.1.37", ")", "."], "h": {"id": "C0051169", "name": "C0051169#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0876231", "name": "C0876231#ent", "pos": [21, 22]}}
{"token": ["The", "analysis", "of", "157", "menstrual", "in", "50", "patients", "on", "ovulation-inducing", "regimens", "showed", "that", "in", "restoring", "ovulation", "C0086213#ent", "<e1>", "citrate", "inhibited", "cervical", "mucus", "production", "and", "caused", "C0037036#ent", "<e2>", "of", "oestradiol", "."], "h": {"id": "C0086213", "name": "C0086213#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0037036", "name": "C0037036#ent", "pos": [25, 26]}}
{"token": ["C3539616#ent", "<e1>", "stimulation", "of", "murine", "NIH", "3T3-F442A", "fibroblasts", ",", "cells", "that", "C1334043#ent", "<e2>", "express", "GHRs", ",", "resulted", "in", "tyrosine", "phosphorylation", "SHP-2", "."], "h": {"id": "C3539616", "name": "C3539616#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [11, 12]}}
{"token": ["In", "addition", "to", "fluorescein", "angiography", "degree", "of", "transitory", "C0020575#ent", "<e1>", "was", "an", "excellent", "indicator", "of", "the", "activity", "of", "the", "C0027721#ent", "<e2>"], "h": {"id": "C0020575", "name": "C0020575#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0027721", "name": "C0027721#ent", "pos": [19, 20]}}
{"token": ["Electron", "microscopic", "analyses", "confirmed", "the", "presence", "of", "C3890744#ent", "<e1>", "in", "the", "C0702216#ent", "<e2>", "and", "dendrites", "of", "GABAergic", "interneurons", "well", "as", "in", "the", "C0702216#ent", "<e2>", ",", "spines", "and", "dendritic", "shafts", "pyramidal", "cells"], "h": {"id": "C3890744", "name": "C3890744#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0702216", "name": "C0702216#ent", "pos": [11, 12]}}
{"token": ["The", "inhibition", "of", "C0019693#ent", "<e1>", "transcytosis", "by", "blocking", "C1332700#ent", "<e2>", "the", "implication", "of", "specific", "interaction", "between", "the", "viral", "gp120", "sulfated", "moiety", "of", "syndecans", "during", "the", "transcytosis", "of", "mostly", "R5-", "and", "X4-HIV-1", "."], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1332700", "name": "C1332700#ent", "pos": [8, 9]}}
{"token": ["Firstly", ",", "we", "developed", "a", "multicolour", "fluorescent", "in", "situ", "hybridisation", "FISH", ")", "assay", "using", "probes", "for", "the", "four", "major", "C3273590#ent", "<e1>", "genes", "and", "for", "two", "candidate", "genes", "(", "C1426351#ent", "<e2>", "and", "FOXA2", ")", "."], "h": {"id": "C3273590", "name": "C3273590#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1426351", "name": "C1426351#ent", "pos": [28, 29]}}
{"token": ["The", "data", "suggest", "that", "C1721358#ent", "<e1>", "may", "influence", "breast", "cancer", "prognosis", "and", "support", "the", "notion", "that", "C1417213#ent", "<e2>", "has", "an", "inhibitory", "effect", "on", "cancer", "metastasis"], "h": {"id": "C1721358", "name": "C1721358#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1417213", "name": "C1417213#ent", "pos": [16, 17]}}
{"token": ["The", "secretion", "of", "prostate-specific", "antigen", "PSA", ")", "and", "the", "mRNA", "expression", "of", "PSA", ",", "C0312402#ent", "<e1>", "PAP", ")", ",", "and", "diazepam-binding", "inhibitor", "C1413917#ent", "<e2>", ")", "were", "used", "as", "parameters", "reflecting", "differentiated", "function"], "h": {"id": "C0312402", "name": "C0312402#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1413917", "name": "C1413917#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "clinical", "factors", "related", "to", "the", "aqueous", "humor", "levels", "of", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "and", "hepatocyte", "growth", "factor", "C1524023#ent", "<e1>", ")", "in", "patients", "with", "C0004606#ent", "<e2>", "PDR", ")", "."], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0004606", "name": "C0004606#ent", "pos": [27, 28]}}
{"token": ["Toxicity", "was", "sometimes", "severe", "with", "3", "infectious", "deaths", "1", "pneumocystis", "carinii", "C0032285#ent", "<e1>", ",", "1", "gram", "negative", "septicemia", ",", "and", "1", "C0339961#ent", "<e2>", ",", "and", "6", "grade", "3", "4", "infectious", "episodes"], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0339961", "name": "C0339961#ent", "pos": [21, 22]}}
{"token": ["C0700482#ent", "<e1>", "is", "an", "C0012544#ent", "<e2>", "that", "is", "able", "to", "increase", "bone", "mass", "by", "inhibiting", "bone", "resorption"], "h": {"id": "C0700482", "name": "C0700482#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0012544", "name": "C0012544#ent", "pos": [4, 5]}}
{"token": ["This", "step", "is", "prevented", "by", "glutathionylation", "of", "the", "sulfenic", "derivative", "to", "form", "a", "S-glutathionylated", "C1709439#ent", "<e1>", ",", "which", "can", "be", "reactivated", "by", "dithiothreitol", "or", "C1870389#ent", "<e2>", "."], "h": {"id": "C1709439", "name": "C1709439#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1870389", "name": "C1870389#ent", "pos": [24, 25]}}
{"token": ["Addition", "of", "C1511755#ent", "<e1>", "completely", "prevented", "detection", "of", "1-hydroxyethyl", "radicals", "with", "C1849722#ent", "<e2>", "or", "DMPO", ",", "but", "caused", "only", "50", "%", "decrease", "in", "EPR", "signals", "when", "POBN", "was", "the", "spin", "trap"], "h": {"id": "C1511755", "name": "C1511755#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1849722", "name": "C1849722#ent", "pos": [11, 12]}}
{"token": ["C2987232#ent", "<e1>", "selective", "and", "C0304516#ent", "<e2>", "triglycerides", "(", "average", "of", "30", "%", ")", "and", "lower", "HDL", "cholesterol", "average", "of", "5", "-", "15", "%", ")", "."], "h": {"id": "C2987232", "name": "C2987232#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0304516", "name": "C0304516#ent", "pos": [4, 5]}}
{"token": ["Furthermore", ",", "to", "evaluate", "the", "immune", "surveillance", "system", "the", "susceptibility", "to", "apoptosis", ",", "immunohistochemical", "staining", "human", "leukocyte", "antigen", "(HLA)-DRalpha", "C1332805#ent", "<e1>", "B", "cell", "leukemia-2", "bcl-2", ")", ",", "bcl-2-associated", "X", "protein", "bax", ")", "and", "C0291573#ent", "<e2>", "also", "performed", "."], "h": {"id": "C1332805", "name": "C1332805#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [33, 34]}}
{"token": ["Using", "this", "model", ",", "we", "tested", "DNA", "and", "C0042214#ent", "<e1>", "their", "ability", "to", "control", "tumors", "downregulated", "C0017355#ent", "<e2>", "expression", "."], "h": {"id": "C0042214", "name": "C0042214#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017355", "name": "C0017355#ent", "pos": [16, 17]}}
{"token": ["In", "two", "clinical", "trials", "C0043369#ent", "<e1>", "was", "found", "efficient", "to", "prevent", "the", "development", "of", "C2827407#ent", "<e2>", "with", "a", "daily", "dose", "8.4", "-", "10", "g", "of", "C0043369#ent", "<e1>", "given", "in", "five", "divided", "doses", "."], "h": {"id": "C2827407", "name": "C2827407#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0043369", "name": "C0043369#ent", "pos": [4, 5]}}
{"token": ["We", "also", "included", "a", "nonconsecutive", "AIDS", "patient", "with", "recent", "worsening", "of", "C0037090#ent", "<e1>", "had", "had", "lymphocytic", "interstitial", "pneumonitis", "C0264511#ent", "<e2>", ")", "diagnosed", "six", "months", "earlier", "."], "h": {"id": "C0037090", "name": "C0037090#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0264511", "name": "C0264511#ent", "pos": [18, 19]}}
{"token": ["Consequently", ",", "muscle", "fatigue", "a", "debilitating", "aspect", "of", "MG", "often", "leading", "to", "more", "general", "feelings", "of", "C0015672#ent", "<e1>", "not", "directly", "due", "to", "C0030552#ent", "<e2>"], "h": {"id": "C0015672", "name": "C0015672#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [22, 23]}}
{"token": ["Roughly", "half", "of", "C0948008#ent", "<e1>", "heralded", "by", "transient", "ischemic", "attacks", "C0007787#ent", "<e2>", ")", "."], "h": {"id": "C0948008", "name": "C0948008#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0007787", "name": "C0007787#ent", "pos": [10, 11]}}
{"token": ["In", "SS", "neurons", "for", "the", "C0036091#ent", "<e1>", "the", "ratio", "of", "the", "C0022614#ent", "<e2>", "component", "to", "the", "total", "excitatory", "postsynaptic", "current", "(", "EPSC", ")", "was", "larger", "than", "that", "of", "the", "non-NMDA", "component", "."], "h": {"id": "C0036091", "name": "C0036091#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022614", "name": "C0022614#ent", "pos": [11, 12]}}
{"token": ["C0010324#ent", "<e1>", "II", "and", "C0017551#ent", "<e2>", "familial", "unconjugated", "hyperbilirubinemias", "caused", "by", "genetic", "lesions", "a", "single", "complex", "locus", "encoding", "for", "bilirubin-UDP-glucuronosyltransferase", "which", "is", "involved", "in", "the", "detoxification", "of", "bilirubin", "by", "conjugation", "with", "glucuronic", "acid"], "h": {"id": "C0010324", "name": "C0010324#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0017551", "name": "C0017551#ent", "pos": [4, 5]}}
{"token": ["L-DOPA", "as", "a", "probable", "C0243051#ent", "<e1>", "of", "baroreceptor", "afferents", "functions", "as", "a", "C3543842#ent", "<e2>", "to", "mediate", "cardiodepressor", "control", "in", "the", "nucleus", "tractus", "solitarii", "NTS", ")", "."], "h": {"id": "C0243051", "name": "C0243051#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [12, 13]}}
{"token": ["The", "infection", "can", "originate", "from", "contiguous", "sites", "of", "existing", "infections", ",", "such", "as", "C0271441#ent", "<e1>", "dental", "infection", "mastoiditis", ",", "or", "C0149512#ent", "<e2>", ",", "where", "anaerobic", "bacteria", "."], "h": {"id": "C0271441", "name": "C0271441#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0149512", "name": "C0149512#ent", "pos": [20, 21]}}
{"token": ["Sensor", "chips", "with", "C0052128#ent", "<e1>", "TAT-complex", ")", "were", "digested", "with", "C1947941#ent", "<e2>", "on", "the", "sensor", "element", "subsequently", "identified", "by", "peptide", "mass", "fingerprint", "PMF", ")", "with", "matrix", "assisted", "laser", "desorption/ionization", "time-of-flight", "(MALDI-ToF)", "mass", "spectrometry"], "h": {"id": "C0052128", "name": "C0052128#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [10, 11]}}
{"token": ["The", "experimental", "results", "that", "the", "SGP", "mediated", "its", "cell", "cycle", "arrest", "a", "site", "in", "the", "cell", "cycle", "was", "at", "the", "time", "of", "C0694889#ent", "<e1>", "phosphorylation", "or", "somewhat", "upstream", "of", "the", "modification", "of", "this", "C0086903#ent", "<e2>", "cell", "division"], "h": {"id": "C0694889", "name": "C0694889#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0086903", "name": "C0086903#ent", "pos": [33, 34]}}
{"token": ["Once", "MMP", "has", "been", "induced", ",", "it", "causes", "the", "release", "of", "C0020289#ent", "<e1>", "activators", "of", "such", "enzymes", "(", "including", "those", "of", "C0010656#ent", "<e2>", ")", "from", "mitochondria", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [21, 22]}}
{"token": ["Type", "II", "ulcers", "mimic", "C0042344#ent", "<e1>", "may", "be", "overlooked", "as", "evidence", "of", "C0025677#ent", "<e2>", "toxicity", "."], "h": {"id": "C0042344", "name": "C0042344#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0025677", "name": "C0025677#ent", "pos": [12, 13]}}
{"token": ["PMA-induced", "mitochondrial", "localization", "of", "PKCalpha", "was", "accompanied", "by", "increased", "mitochondrial", "C1826724#ent", "<e1>", "activity", ",", "altered", "cell", "morphology", "disruption", "of", "mitochondrial", "membrane", "potential", "decreased", "C0171406#ent", "<e2>", "pyruvate", "dehydrogenase", "activities", ",", "and", "increased", "mitochondrial", "ROS", "production", "."], "h": {"id": "C1826724", "name": "C1826724#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [23, 24]}}
{"token": ["The", "function", "of", "several", "of", "the", "major", "muscles", "crossing", "the", "C1709823#ent", "<e1>", "and", "knee", "joints", "reported", "for", "the", "different", "C0030196#ent", "<e2>", "positions", "corresponding", "to", "normal", "gait"], "h": {"id": "C1709823", "name": "C1709823#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [19, 20]}}
{"token": ["C0004609#ent", "<e1>", "did", "not", "alter", "the", "magnitude", "of", "ethanol-induced", "C3540513#ent", "<e2>", "at", "any", "dose", "."], "h": {"id": "C0004609", "name": "C0004609#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540513", "name": "C3540513#ent", "pos": [9, 10]}}
{"token": ["Combination", "therapy", "selective", "cholesterol", "absorption", "inhibitors", "as", "ezetimibe", "along", "with", "statins", "or", "C1449704#ent", "<e1>", "may", "allow", "more", "patients", "with", "C0020445#ent", "<e2>", "to", "achieve", "target", "LDL-C", "levels", "compared", "with", "treatment", "with", "monotherapy", "."], "h": {"id": "C1449704", "name": "C1449704#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0020445", "name": "C0020445#ent", "pos": [19, 20]}}
{"token": ["Neuroleptic", "agents", "pimozide", ",", "haloperidol", ",", "chlorpromazine", "and", "C0033399#ent", "<e1>", "were", "far", "less", "potent", "C0003364#ent", "<e2>"], "h": {"id": "C0033399", "name": "C0033399#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [14, 15]}}
{"token": ["In", "the", "present", "study", ",", "we", "examined", "the", "possible", "role", "of", "C0033551#ent", "<e1>", "(", "COX", ")", "in", "the", "C1414672#ent", "<e2>", "of", "mouse", "paw", "oedema", "by", "BaV", "and", "BjV", "injections", "."], "h": {"id": "C0033551", "name": "C0033551#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414672", "name": "C1414672#ent", "pos": [18, 19]}}
{"token": ["S1P-induced", "migration", "of", "adult-medial", "VSMCs", "expressing", "exogenous", "C3539578#ent", "<e1>", "required", "G(i)", "activation", "but", "not", "C1138418#ent", "<e2>"], "h": {"id": "C3539578", "name": "C3539578#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1138418", "name": "C1138418#ent", "pos": [14, 15]}}
{"token": ["DNA", "microarray", "between", "B", "cells", "wild-type", "and", "mutant", "for", "the", "master", "regulator", "MHC", "class", "II", "transcription", "class", "II", "transactivator", "C1824738#ent", "<e1>", ")", ",", "identified", "HLA-DOA", "and", "C1415566#ent", "<e2>", "as", "being", "up-regulated", "by", "C1824738#ent", "<e1>", "."], "h": {"id": "C1824738", "name": "C1824738#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1415566", "name": "C1415566#ent", "pos": [26, 27]}}
{"token": ["Seventeen", "missense", "mutations", "C0000340#ent", "<e1>", "CYP27B1", ")", "that", "cause", "C0268689#ent", "<e2>", "VDDR-I", ")", "have", "been", "identified", "."], "h": {"id": "C0000340", "name": "C0000340#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268689", "name": "C0268689#ent", "pos": [9, 10]}}
{"token": ["Human", "C0076726#ent", "<e1>", "identified", "in", "pancreas", ",", "salivary", "gland", "kidney", ",", "C0023899#ent", "<e2>", ",", "and", "spleen", "of", "the", "transgenic", "mice", "a", "specific", "radioimmunoassay", "for", "human", "C0076726#ent", "<e1>"], "h": {"id": "C0076726", "name": "C0076726#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [11, 12]}}
{"token": ["In", "conclusion", ",", "administration", "of", "C0054201#ent", "<e1>", "leads", "to", "markedly", "elevated", "plasma", "levels", "cirrhotic", "patients", "with", "C0008312#ent", "<e2>", "associated", "with", "adverse", "drug", "reactions"], "h": {"id": "C0054201", "name": "C0054201#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0008312", "name": "C0008312#ent", "pos": [16, 17]}}
{"token": ["Trichostatin", "A", "TSA", ")", ",", "a", "potent", "histone", "deacetylase", "HDAC", ")", "C0919438#ent", "<e1>", "used", "to", "test", "the", "role", "of", "histone", "hyperacetylation", "the", "transcriptional", "regulation", "C0087140#ent", "<e2>", "and", "c-jun", "genes", "neuronal", "cells", "in", "vivo", "in", "vitro"], "h": {"id": "C0919438", "name": "C0919438#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [24, 25]}}
{"token": ["Syndromic", "MCDs", "with", "CNS", "involvement", "include", "mitochondrial", "encephalomyopathy", "lactacidosis", ",", "stroke-like", "episodes", "syndrome", ",", "myoclonic", "epilepsy", "ragged", "red", "fibers", "syndrome", "mitochondrial", "neuro-gastrointestinal", "encephalomyopathy", "syndrome", "neurogenic", "muscle", "weakness", "C0004134#ent", "<e1>", ",", "and", "retinitis", "pigmentosa", "syndrome", "mitochondrial", "depletion", "syndrome", "Kearns-Sayre", "syndrome", "and", "Leigh", "syndrome", "C0917796#ent", "<e2>", "Friedreich's", "ataxia", "and", "multiple", "systemic", "lipomatosis"], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [27, 28]}, "relation": "manifestation_of", "t": {"id": "C0917796", "name": "C0917796#ent", "pos": [42, 43]}}
{"token": ["Since", "the", "long", "arm", "of", "8", "is", "frequently", "the", "site", "of", "increased", "gene", "copy", "number", "ICN", ")", "in", "breast", "cancer", "we", "screened", "442", "breast", "tumor", "C0011522#ent", "<e1>", "for", "gains", "of", "E2F5", ",", "MOS", ",", "and", "C0026902#ent", "<e2>"], "h": {"id": "C0011522", "name": "C0011522#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0026902", "name": "C0026902#ent", "pos": [35, 36]}}
{"token": ["Among", "patients", "with", "the", "C3496337#ent", "<e1>", "have", "focal", "and", "C0017668#ent", "<e2>", "undergo", "renal", "transplantation", "15", "to", "55", "percent", "have", "recurrent", "nephrotic", "syndrome"], "h": {"id": "C3496337", "name": "C3496337#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0017668", "name": "C0017668#ent", "pos": [9, 10]}}
{"token": ["DNMT3B", "also", "interacts", "with", "histone", "deacetylase", "1", "HDAC1", ")", ",", "the", "co-repressor", "C1426185#ent", "<e1>", "and", "the", "C0101555#ent", "<e2>", "chromatin", "remodeling", "enzyme", "hSNF2H", "."], "h": {"id": "C1426185", "name": "C1426185#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [16, 17]}}
{"token": ["The", "brainiac", "gene", "encodes", "a", "C1335807#ent", "<e1>", "similar", "to", "mammalian", "C0085249#ent", "<e2>", "."], "h": {"id": "C1335807", "name": "C1335807#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085249", "name": "C0085249#ent", "pos": [10, 11]}}
{"token": ["C0000744#ent", "<e1>", "(", "CHAC", ")", "is", "an", "autosomal", "recessive", "disease", "by", "neurodegeneration", "and", "C0000744#ent", "<e1>", "."], "h": {"id": "C0000744", "name": "C0000744#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0000744", "name": "C0000744#ent", "pos": [0, 1]}}
{"token": ["Diseases", "in", "which", "transfer", "factor", "to", "cause", "improvement", "include", "the", "Wiskott-Aldrich", "syndrome", "severe", "combined", "immunodeficiency", "disease", "C0006845#ent", "<e1>", "chronic", "active", "hepatitis", "coccidioidmycosis", ",", "dysgammaglobulinemia", ",", "Behcet", "disease", "aphthous", "stomatitis", "C1527383#ent", "<e2>", "familial", "keratoacanthoma", "malignancy", "."], "h": {"id": "C0006845", "name": "C0006845#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1527383", "name": "C1527383#ent", "pos": [29, 30]}}
{"token": ["We", "established", "a", "bacterial", "system", "high-level", "over-expression", "of", "the", "spinach", "C3179066#ent", "<e1>", "encodes", "the", "C1412653#ent", "<e2>"], "h": {"id": "C3179066", "name": "C3179066#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1412653", "name": "C1412653#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "fon-RNAi", "larvae", "exhibit", "melanotic", "tumors", "and", "C0907533#ent", "<e1>", "expression", "of", "the", "antifungal", "peptide", "gene", "Drosomycin", "(", "C0013261#ent", "<e2>", ")", ",", "while", "fon-RNAi", "pupae", "display", "an", "aberrant", "pupal", "phenotype", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013261", "name": "C0013261#ent", "pos": [19, 20]}}
{"token": ["It", "has", "been", "demonstrated", "that", "the", "NO", "*", "produced", "by", "C0907533#ent", "<e1>", "by", "the", "reduction", "of", "nitrite", "by", "C0068800#ent", "<e2>", "an", "important", "role", "in", "plants", "'", "defense", "against", "microbial", "pathogens", "."], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0068800", "name": "C0068800#ent", "pos": [18, 19]}}
{"token": ["We", "have", "compared", "ADH2", ",", "ADH3", "and", "C1412335#ent", "<e1>", "allele", "frequencies", "patients", "with", "C0023891#ent", "<e2>", "n", "=", "59", ")", "and", "chronic", "pancreatitis", "n", "=", "13", ")", "with", "79", "local", "healthy", "control", "subjects", "."], "h": {"id": "C1412335", "name": "C1412335#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023891", "name": "C0023891#ent", "pos": [13, 14]}}
{"token": ["80", "adult", "outpatients", "suffering", "from", "otitis", "media", "C0149512#ent", "<e1>", "(", "maxillaris", "or", "frontalis", ")", "or", "C0877267#ent", "<e2>", "were", "treated", "with", "mg", "ciprofloxacin", "b.i.d", "."], "h": {"id": "C0149512", "name": "C0149512#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0877267", "name": "C0877267#ent", "pos": [15, 16]}}
{"token": ["This", "regulatory", "role", "become", "displaced", "under", "certain", "circumstances", "such", "as", "aging", ",", "autoimmune", "responses", "C0042769#ent", "<e1>", "leading", "to", "the", "pathological", "outcome", "associated", "with", "inflammatory", "and", "C1285162#ent", "<e2>", "the", "CNS", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [25, 26]}}
{"token": ["Neuropathological", "and", "epidemiological", "data", "in", "investigated", "patients", "are", "discussed", "from", "the", "point", "of", "view", "of", "a", "possible", "relationship", "between", "the", "C0042769#ent", "<e1>", "by", "unconventional", "agents", "and", "C1285162#ent", "<e2>", "affecting", "the", "ocular", "system"], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1285162", "name": "C1285162#ent", "pos": [26, 27]}}
{"token": ["Pharmacologically", ",", "some", "of", "these", "agents", "can", "be", "distinguished", "from", "pure", "C1413043#ent", "<e1>", "+", "entry", "blockers", "being", "more", "effective", "vs.", "vasoconstrictor", "agents", "in", "vitro", "less", "C0027048#ent", "<e2>", "and", "more", "effective", "as", "platelet", "aggregation", "inhibitors"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027048", "name": "C0027048#ent", "pos": [25, 26]}}
{"token": ["Here", ",", "lipophilicity", "is", "discussed", "with", "reference", "to", "the", "human", "drug-metabolizing", "P450", "C0014442#ent", "<e1>", "of", "families", "CYP1", ",", "CYP2", "and", "C1418799#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418799", "name": "C1418799#ent", "pos": [20, 21]}}
{"token": ["The", "risks", "faced", "in", "C0001206#ent", "<e1>", ",", "for", "instance", ",", "are", "not", "necessarily", "shared", "by", "C0041408#ent", "<e2>", "patients", "treated", "with", "GH", "."], "h": {"id": "C0001206", "name": "C0001206#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0041408", "name": "C0041408#ent", "pos": [15, 16]}}
{"token": ["If", "unchecked", ",", "the", "disease", "may", "lead", "to", "C0006267#ent", "<e1>", "and", "ultimately", "C0034069#ent", "<e2>"], "h": {"id": "C0006267", "name": "C0006267#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [12, 13]}}
{"token": ["Aripiprazole", ",", "(+)terguride", ",", "C0069564#ent", "<e1>", "and", "(-)3-PPP", "have", "been", "classified", "as", "C1707622#ent", "<e2>", "largely", "on", "their", "activity", "in", "second", "messenger-based", "assays", "of", "dopamine", "D(2)", "receptor", "signalling", "."], "h": {"id": "C0069564", "name": "C0069564#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1707622", "name": "C1707622#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "here", "a", "second", "strategy", "to", "increase", "the", "amount", "of", "intracellular", "triphosphorylated", "GCV", "by", "involving", "the", "second", "C0014442#ent", "<e1>", "in", "the", "GCV", "activation", "pathway", "C1415367#ent", "<e2>", "GMK", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1415367", "name": "C1415367#ent", "pos": [25, 26]}}
{"token": ["Possible", "predisposing", "causes", "include", "smoking", "and", "sexual", "behaviour", "particularly", "homosexual", "anal", "intercourse", "chronic", "inflammation", "Crohn", ",", "anal", "fistula", "fissure", ",", "sepsis", ",", "hydradenitis", "suppurativa", ",", "and", "C0162534#ent", "<e1>", "human", "papillomavirus", "type", "16", "y", "18", ",", "C0009663#ent", "<e2>", "."], "h": {"id": "C0162534", "name": "C0162534#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C0009663", "name": "C0009663#ent", "pos": [35, 36]}}
{"token": ["Furthermore", ",", "impaired", "cytokine", "production", "observed", "in", "PBMCs", "from", "C0151517#ent", "<e1>", "patients", "after", "challenged", "with", "C1336634#ent", "<e2>", "and", "TLR4", "ligands", "and", "was", "correlated", "with", "the", "levels", "of", "plasma", "hepatitis", "B", "virus", "surface", "antigen", "HBsAg", ")", "."], "h": {"id": "C0151517", "name": "C0151517#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1336634", "name": "C1336634#ent", "pos": [15, 16]}}
{"token": ["The", "systemic", "levels", "the", "proangiogenic", "bFGF", ",", "the", "antiangiogenic", "endostatin", "the", "C1540291#ent", "<e1>", "sE-selectin", "showed", "significant", "correlations", ",", "whereas", "C1367482#ent", "<e2>", "and", "sE-selectin", "levels", "were", "not", "correlated", "."], "h": {"id": "C1540291", "name": "C1540291#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1367482", "name": "C1367482#ent", "pos": [19, 20]}}
{"token": ["The", "C0071894#ent", "<e1>", "determined", "to", "be", "a", "28.5-kDa", "protein", "consisting", "of", "a", "C1305923#ent", "<e2>"], "h": {"id": "C0071894", "name": "C0071894#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1305923", "name": "C1305923#ent", "pos": [12, 13]}}
{"token": ["In", "addition", "to", "corticosteroids", ",", "treatment", "options", "include", "immunosuppressant", "agents", "C0010583#ent", "<e1>", "or", "azathioprine", ")", "aspirin", ",", "calcium", "channel", "blockers", "C0028094#ent", "<e2>", ")", ",", "intravenous", "immunoglobulin", "and", "plasmapheresis", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0028094", "name": "C0028094#ent", "pos": [20, 21]}}
{"token": ["The", "morbilliviruses", "which", "infect", "ruminants", ",", "C0035637#ent", "<e1>", "(", "RPV", ")", "and", "C0949885#ent", "<e2>", "PPRV", ")", ",", "are", "difficult", "to", "distinguish", "serologically", "."], "h": {"id": "C0035637", "name": "C0035637#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0949885", "name": "C0949885#ent", "pos": [12, 13]}}
{"token": ["To", "our", "surprise", ",", "deglycosylated", "C1456795#ent", "<e1>", "precursor", "was", "taken", "up", "by", "C1334090#ent", "<e2>", "knock", "out", "mouse", "fibroblasts", "more", "efficiently", "than", "the", "glycosylated", "protein"], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1334090", "name": "C1334090#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "the", "reported", "linkage", "of", "acquired", "sideroblastic", "anemia", "sideroblastic", "anemia", "C0004134#ent", "<e1>", "to", "Xq13", "presumably", "results", "from", "C1417679#ent", "<e2>", "other", "than", "ALAS2", "."], "h": {"id": "C0004134", "name": "C0004134#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [18, 19]}}
{"token": ["The", "Bardet-Biedl", "syndrome", "characterized", "by", "five", "main", "features", ":", "obesity", ",", "polydactyly", ",", "pigmentary", "retinopathy", "mental", "deficiency", "C0151721#ent", "<e1>", ";", "recently", "a", "sixth", "feature", ",", "C0022658#ent", "<e2>", "has", "been", "described", "."], "h": {"id": "C0151721", "name": "C0151721#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [25, 26]}}
{"token": ["Here", ",", "interdependencies", "between", "C3890227#ent", "<e1>", "and", "the", "C1416692#ent", "<e2>", "MCAK", "were", "analyzed", "in", "human", "leukemia", "cells"], "h": {"id": "C3890227", "name": "C3890227#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416692", "name": "C1416692#ent", "pos": [8, 9]}}
{"token": ["We", "show", "that", "endothelin-1", "(", "C3273436#ent", "<e1>", ")", "stimulation", "of", "primary", "human", "mesangial", "cells", "C0948368#ent", "<e2>", ")", "induces", "betaPix", "and", "p66Shc", "up-regulation", ",", "resulting", "in", "the", "formation", "of", "the", "betaPix/p66Shc", "complex", "."], "h": {"id": "C3273436", "name": "C3273436#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0948368", "name": "C0948368#ent", "pos": [14, 15]}}
{"token": ["Surgical", "treatment", "C0017168#ent", "<e1>", "highly", "effective", "although", "postoperative", "C2930966#ent", "<e2>", "dysphagia", "and", "recurrence", "may", "occur", "in", "a", "small", "number", "of", "patients", "."], "h": {"id": "C0017168", "name": "C0017168#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2930966", "name": "C2930966#ent", "pos": [8, 9]}}
{"token": ["Tc-99m-sestaMIBI", "(", "MIBI", ")", "uptake", "determined", "by", "breast", "scintigraphy", "C1413274#ent", "<e1>", "expression", "of", "tumor", "tissue", "by", "immunohistochemistry", "are", "suggested", "as", "potential", "C0035064#ent", "<e2>", "for", "this", "purpose", "."], "h": {"id": "C1413274", "name": "C1413274#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [21, 22]}}
{"token": ["In", "vitro", "studies", "using", "cultured", "hepatocytes", "indicated", "that", "expression", "of", "C1420134#ent", "<e1>", "was", "up-regulated", "by", "treatment", "with", "C0033017#ent", "<e2>", "PCN", ")", "and", "by", "overexpression", "of", "rat", "pregnane", "X", "receptor", "PXR", ")", "."], "h": {"id": "C1420134", "name": "C1420134#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0033017", "name": "C0033017#ent", "pos": [17, 18]}}
{"token": ["1", "Labetalol", ",", "an", "alpha-", "and", "beta-", "adrenoceptor", "blocking", "C0013227#ent", "<e1>", ",", "was", "compared", "with", "acebutolol", ",", "alone", "or", "associated", "with", "C0012271#ent", "<e2>", "in", "forty", "patients", "with", "moderate", "essential", "hypertension"], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0012271", "name": "C0012271#ent", "pos": [21, 22]}}
{"token": ["The", "C0017337#ent", "<e1>", "encoding", "whirlin", "also", "underlies", "the", "human", "autosomal", "recessive", "deafness", "C4085316#ent", "<e2>"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4085316", "name": "C4085316#ent", "pos": [12, 13]}}
{"token": ["The", "observed", "structural", "complementation", "between", "the", "interacting", "surfaces", "of", "C1624014#ent", "<e1>", "and", "Exophilin4", "sheds", "light", "on", "the", "disparities", "among", "the", "C1419195#ent", "<e2>", "effectors", "and", "outlines", "a", "general", "mechanism", "for", "their", "recruitment", "."], "h": {"id": "C1624014", "name": "C1624014#ent", "pos": [9, 10]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1419195", "name": "C1419195#ent", "pos": [20, 21]}}
{"token": ["All", "C1456390#ent", "<e1>", "contain", "highly", "conserved", "aromatic", "residues", "involved", "in", "C2698697#ent", "<e2>", "binding", "which", "are", "presumably", "implicated", "in", "the", "interaction", "with", "proline-rich", "motif", "proteins"], "h": {"id": "C1456390", "name": "C1456390#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2698697", "name": "C2698697#ent", "pos": [10, 11]}}
{"token": ["A", "second", "gel", "containing", "C0010656#ent", "<e1>", "then", "laid", "above", "the", "C1333402#ent", "<e2>", "initiate", "the", "reaction", "."], "h": {"id": "C0010656", "name": "C0010656#ent", "pos": [4, 5]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [10, 11]}}
{"token": ["The", "mutant", "spores", "sensitive", "to", "UV-light", "compared", "to", "the", "C2987364#ent", "<e1>", "spores", ",", "indicating", "that", "C1706870#ent", "<e2>", "protects", "spores", "from", "cellular", "damage", "by", "UV-light", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1706870", "name": "C1706870#ent", "pos": [15, 16]}}
{"token": ["We", "have", "previously", "identified", "mutant", "alleles", "of", "C0017337#ent", "<e1>", "encoding", "two", "C0752065#ent", "<e2>", "Ypt3", "and", "Ryh1", ",", "through", "a", "genetic", "screen", "the", "immunosuppressant", "drug", "FK506", "in", "fission", "yeast"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0752065", "name": "C0752065#ent", "pos": [11, 12]}}
{"token": ["In", "contrast", ",", "unlike", "normal", "peripheral", "blood", "monocytes", "or", "alveolar", "macrophages", "C0003873#ent", "<e1>", "synovial", "tissue", "constitutively", "expressed", "C1705079#ent", "<e2>", "mRNA", "and", "antigen", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [11, 12]}, "relation": "disease_has_associated_gene", "t": {"id": "C1705079", "name": "C1705079#ent", "pos": [17, 18]}}
{"token": ["The", "high-resolution", "crystal", "structure", "of", "C3539751#ent", "<e1>", "in", "complex", "with", "the", "C-terminal", "peptide", "C1332803#ent", "<e2>", "provides", "molecular", "details", "the", "recognition", "of", "C1332803#ent", "<e2>", "by", "C3539751#ent", "<e1>", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3539751", "name": "C3539751#ent", "pos": [5, 6]}}
{"token": ["The", "clinical", "feature", "the", "C0025289#ent", "<e1>", "is", "characteristic", "with", "severe", "C4021534#ent", "<e2>", "developing", "early", "during", "the", "course", "of", "C0025289#ent", "<e1>", "."], "h": {"id": "C4021534", "name": "C4021534#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [4, 5]}}
{"token": ["There", "was", "no", "significant", "in", "head", "circumference", "no", "detectable", "C4021534#ent", "<e1>", "and", "no", "detected", "difference", "in", "intellectual", "functioning", "the", "C0025289#ent", "<e2>", "group", "and", "matched", "control", "."], "h": {"id": "C4021534", "name": "C4021534#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0025289", "name": "C0025289#ent", "pos": [19, 20]}}
{"token": ["At", "low", "membrane", "protein", "30", "microM", "calmidazolium", "completely", "blocked", "C0249866#ent", "<e1>", "pumping", "ATPase", "whereas", "the", "inhibition", "caused", "by", "30", "microM", "C0015772#ent", "<e2>", "or", "bepridil", "remained", "partially", "."], "h": {"id": "C0249866", "name": "C0249866#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0015772", "name": "C0015772#ent", "pos": [20, 21]}}
{"token": ["The", "mitogenic", "activity", "C0065610#ent", "<e1>", "was", "generally", "in", "agreement", "with", "the", "C1418482#ent", "<e2>", "response", "stimulation", "by", "it", "."], "h": {"id": "C0065610", "name": "C0065610#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418482", "name": "C1418482#ent", "pos": [11, 12]}}
{"token": ["C0031667#ent", "<e1>", "response", "followed", "those", "of", "TNF", "and", "C1334122#ent", "<e2>", "but", "was", "quantitatively", "different", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1334122", "name": "C1334122#ent", "pos": [8, 9]}}
{"token": ["As", "the", "patient", "refused", "surgical", "resection", "the", "pancreas", "tumor", "we", "started", "to", "use", "the", "C3536825#ent", "<e1>", "octreotide", ",", "for", "treatment", "of", "C0020615#ent", "<e2>", "."], "h": {"id": "C3536825", "name": "C3536825#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [21, 22]}}
{"token": ["We", "suspected", "C0020615#ent", "<e1>", "or", "central", "apnea", "be", "the", "cause", "of", "apnea", "and", "started", "the", "administration", "of", "C3536825#ent", "<e2>", "a", "treatment", "for", "C0020615#ent", "<e1>", "."], "h": {"id": "C3536825", "name": "C3536825#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [2, 3]}}
{"token": ["The", "values", "of", "C0058310#ent", "<e1>", "studied", "in", "20", "renal", "patients", "with", "C0020544#ent", "<e2>", "with", "and", "without", "chronic", "renal", "insufficiency", "a", "radioimmunologic", "method", "."], "h": {"id": "C0058310", "name": "C0058310#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020544", "name": "C0020544#ent", "pos": [11, 12]}}
{"token": ["The", "increase", "in", "contractility", "by", "C1705396#ent", "<e1>", "was", "associated", "with", "increases", "in", "delta", "C0206042#ent", "<e2>", "and", "+", "/-VT", ",", "and", "shortening", "of", "TPT/TPS", "and", "RT(90)/TR(90", ")", "."], "h": {"id": "C1705396", "name": "C1705396#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0206042", "name": "C0206042#ent", "pos": [13, 14]}}
{"token": ["Loss", "of", "one", "allele", "of", "C1332720#ent", "<e1>", "and", "reduced", "C1705432#ent", "<e2>", "expression", "has", "been", "observed", "in", "several", "cancers", ",", "implicating", "its", "association", "with", "carcinogenesis", "."], "h": {"id": "C1332720", "name": "C1332720#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1705432", "name": "C1705432#ent", "pos": [9, 10]}}
{"token": ["C0050396#ent", "<e1>", "(", "N-[(3,5-di(pyrrolidinylmethyl)-4-hydroxy)benzoyl]aniline", ")", "is", "a", "newly", "developed", "analogue", "of", "C0055265#ent", "<e2>", ",", "an", "antiarrhythmic", "agent", "in", "the", "Peoples", "Republic", "of", "China"], "h": {"id": "C0050396", "name": "C0050396#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0055265", "name": "C0055265#ent", "pos": [11, 12]}}
{"token": ["In", "summary", ",", "our", "results", "do", "not", "support", "a", "major", "role", "of", "the", "human", "C1706234#ent", "<e1>", "gene", "in", "the", "development", "of", "C0028754#ent", "<e2>", "our", "population", "."], "h": {"id": "C1706234", "name": "C1706234#ent", "pos": [14, 15]}, "relation": "gene_associated_with_disease", "t": {"id": "C0028754", "name": "C0028754#ent", "pos": [21, 22]}}
{"token": ["The", "particular", "translocation", "in", "follicular", "lymphomas", "FLs", ")", "is", "a", "t(14;18)(q32;q21", ")", ",", "recombining", "the", "C0017351#ent", "<e1>", "IgH", ")", "gene", "on", "chromosome", "14", "the", "C1412765#ent", "<e2>", "BCL2", ")", "gene", "on", "chromosome", "18"], "h": {"id": "C0017351", "name": "C0017351#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1412765", "name": "C1412765#ent", "pos": [24, 25]}}
{"token": ["Virulence", "is", "also", "associated", "with", "bacterial", "surface", "C0032594#ent", "<e1>", ",", "which", "may", "help", "to", "avoid", "host", "defense", "responses", "and", "C0017362#ent", "<e2>", "which", "can", "control", "virulence", "gene", "expression", "."], "h": {"id": "C0032594", "name": "C0032594#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0017362", "name": "C0017362#ent", "pos": [19, 20]}}
{"token": ["It", "has", "been", "suggested", "recently", "that", "the", "bioactivation", "of", "C0008241#ent", "<e1>", "proguanil", ")", "to", "its", "active", "C0003374#ent", "<e2>", "metabolite", "cycloguanil", "cosegregates", "with", "the", "genetically", "determined", "polymorphism", "of", "mephenytoin", "hydroxylation", "."], "h": {"id": "C0008241", "name": "C0008241#ent", "pos": [9, 10]}, "relation": "has_therapeutic_class", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [16, 17]}}
{"token": ["Further", "human", "clinical", "trials", "C0935942#ent", "<e1>", "against", "serious", "C0026946#ent", "<e2>", "in", "progress", "."], "h": {"id": "C0935942", "name": "C0935942#ent", "pos": [4, 5]}, "relation": "may_prevent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [8, 9]}}
{"token": ["The", "subjects", "had", "loaisis", ",", "streptocercosis", "or", "C0024759#ent", "<e1>", "in", "addition", "to", "C0029002#ent", "<e2>", "."], "h": {"id": "C0024759", "name": "C0024759#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0029002", "name": "C0029002#ent", "pos": [12, 13]}}
{"token": ["A", "yeast", "strain", "constructed", "in", "which", "GLN1", ",", "encoding", "C0017801#ent", "<e1>", "and", "GLT1", ",", "encoding", "glutamate", "synthase", "were", "C3889446#ent", "<e2>", ",", "and", "GDH1", ",", "encoding", "the", "NADPH-dependent", "glutamate", "dehydrogenase", "was", "deleted", "."], "h": {"id": "C0017801", "name": "C0017801#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [18, 19]}}
{"token": ["During", "toe-down", ",", "JM", "did", "not", "affect", "TA", "C1856186#ent", "<e1>", ",", "but", "strongly", "diminished", "C1825801#ent", "<e2>", "."], "h": {"id": "C1856186", "name": "C1856186#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1825801", "name": "C1825801#ent", "pos": [14, 15]}}
{"token": ["Exposure", "of", "PC12", "cells", "C1095795#ent", "<e1>", "761", "decreased", "the", "processing", "of", "C0085151#ent", "<e2>", "abolished", "cholesterol-induced", "overproduction", "of", "this", "protein", "."], "h": {"id": "C1095795", "name": "C1095795#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085151", "name": "C0085151#ent", "pos": [11, 12]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "investigate", "the", "haemodynamic", "and", "endocrine", "effects", "the", "C1366499#ent", "<e1>", "inhibitor", "candoxatril", "in", "patients", "with", "congestive", "heart", "failure", "C0019099#ent", "<e2>", ")", "."], "h": {"id": "C1366499", "name": "C1366499#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0019099", "name": "C0019099#ent", "pos": [24, 25]}}
{"token": ["To", "determine", "the", "full-length", "sequence", "of", "a", "C0017337#ent", "<e1>", "with", "similarity", "to", "C1417030#ent", "<e2>", "and", "to", "screen", "for", "mutations", "in", "this", "newly", "characterized", "C0017337#ent", "<e1>", ",", "named", "retinitis", "pigmentosa", "1-like", "1(RP1L1", ")", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417030", "name": "C1417030#ent", "pos": [12, 13]}}
{"token": ["BS69", "mutants", "lacking", "the", "C1423543#ent", "<e1>", "not", "bind", "to", "C1709313#ent", "<e2>", "and", "did", "not", "inhibit", "ubiquitination", "of", "C1709313#ent", "<e2>", "."], "h": {"id": "C1423543", "name": "C1423543#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1709313", "name": "C1709313#ent", "pos": [9, 10]}}
{"token": ["A", "shuttle", "vector", "either", "C1097583#ent", "<e1>", "human", "topoisomerase", "II", "alpha", "yeast", "topoisomerase", "II", "the", "control", "of", "a", "C1416829#ent", "<e2>", "promoter", "was", "used", "."], "h": {"id": "C1097583", "name": "C1097583#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416829", "name": "C1416829#ent", "pos": [17, 18]}}
{"token": ["Quisqualate", "or", "ACPD", ",", "both", "of", "which", "are", "C1333711#ent", "<e1>", "had", "no", "C0728960#ent", "<e2>", "effect", "."], "h": {"id": "C1333711", "name": "C1333711#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [12, 13]}}
{"token": ["Fetal", "global", "C0178540#ent", "<e1>", "is", "most", "commonly", "a", "consequence", "of", "C0032051#ent", "<e2>"], "h": {"id": "C0178540", "name": "C0178540#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0032051", "name": "C0032051#ent", "pos": [10, 11]}}
{"token": ["Only", "ectopic", "expression", "of", "c-K(B)-Ras", ",", "not", "c-K(A)-Ras", "nor", "oncogenic", "C1705519#ent", "<e1>", ",", "could", "restore", "both", "PDGF-dependent", "C0812228#ent", "<e2>", "activation", "and", "cell", "migration"], "h": {"id": "C1705519", "name": "C1705519#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "the", "bolus", "intravenous", "infusion", "of", "C0378974#ent", "<e1>", "is", "considered", "superior", "to", "the", "non-bolus", "intravenous", "infusion", "C0061863#ent", "<e2>", "from", "a", "pharmacoeconomic", "standpoint", "."], "h": {"id": "C0378974", "name": "C0378974#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0061863", "name": "C0061863#ent", "pos": [17, 18]}}
{"token": ["It", "is", "proposed", "that", "C0017920#ent", "<e1>", "depletion", ",", "or", "some", "correlate", ",", "C2712370#ent", "<e2>", "liver", "glucostatic", "regulation", "and", "determines", "refeeding", "after", "deprivation", "."], "h": {"id": "C0017920", "name": "C0017920#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [12, 13]}}
{"token": ["Thus", ",", "the", "C3641847#ent", "<e1>", "and", "VP16", "acidic", "domains", "can", "utilize", "the", "intrinsic", "C0062773#ent", "<e2>", "or", "scaffolding", "properties", "of", "p300", "to", "activate", "transcription", "."], "h": {"id": "C3641847", "name": "C3641847#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0062773", "name": "C0062773#ent", "pos": [13, 14]}}
{"token": ["The", "mitochondrial", "ATP-activated", "potassium", "channel", "K(ATP", ")", ")", "antagonist", "5-hydroxydecanoic", "acid", "inhibited", "C1416867#ent", "<e1>", "and", "diazoxide-induced", "preconditioning", "in", "C1422480#ent", "<e2>", "hearts", ",", "whereas", "it", "had", "no", "effect", "on", "ZO", "hearts", "."], "h": {"id": "C1416867", "name": "C1416867#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1422480", "name": "C1422480#ent", "pos": [18, 19]}}
{"token": ["The", "purified", "C0014442#ent", "<e1>", "was", "susceptible", "to", "hydrolysis", "by", "C0014159#ent", "<e2>", "which", "resulted", "in", "at", "least", "two", "new", "forms", ",", "reduced", "in", "apparent", "molecular", "weight", "approximately", "4,000", "-", "6,000", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014159", "name": "C0014159#ent", "pos": [9, 10]}}
{"token": ["Comparison", "of", "116", "C0026769#ent", "<e1>", "patients", "with", "Caucasoid", "controls", "not", "reveal", "any", "significant", "correlation", "between", "the", "previously", "described", "alleles", "of", "the", "TAP1", "and", "C1704920#ent", "<e2>", "genes", "and", "C0026769#ent", "<e1>", "."], "h": {"id": "C1704920", "name": "C1704920#ent", "pos": [23, 24]}, "relation": "gene_associated_with_disease", "t": {"id": "C0026769", "name": "C0026769#ent", "pos": [3, 4]}}
{"token": ["C0010674#ent", "<e1>", "a", "specific", "disease", "entity", "been", "known", "to", "be", "associated", "with", "C0022806#ent", "<e2>", "for", "almost", "half", "a", "century", "."], "h": {"id": "C0010674", "name": "C0010674#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0022806", "name": "C0022806#ent", "pos": [12, 13]}}
{"token": ["C0287531#ent", "<e1>", "DSPs", ")", "are", "a", "subclass", "within", "the", "C1335554#ent", "<e2>", "PTPs", ")", "."], "h": {"id": "C0287531", "name": "C0287531#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335554", "name": "C1335554#ent", "pos": [9, 10]}}
{"token": ["C0024530#ent", "<e1>", "continues", "to", "be", "the", "most", "important", "C0033740#ent", "<e2>", "the", "world", ",", "and", "currently", "a", "possible", "reintroduction", "of", "this", "infection", "is", "observed", "in", "Spain", "."], "h": {"id": "C0024530", "name": "C0024530#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0033740", "name": "C0033740#ent", "pos": [8, 9]}}
{"token": ["Alteration", "of", "the", "components", "of", "the", "C0633227#ent", "<e1>", "including", "cytochrome", "P450", "cytochrome", "b5", "cytochrome", "P450", "reductase", "and", "C0056921#ent", "<e2>", "was", "examined", "in", "liver", "microsomes", "prepared", "from", "needle", "biopsy", "samples", "of", "12", "patients", "with", "intrahepatic", "cholestasis"], "h": {"id": "C0633227", "name": "C0633227#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0056921", "name": "C0056921#ent", "pos": [17, 18]}}
{"token": ["To", "study", "the", "mechanisms", "of", "MDR1", "activation", "related", "to", "taxanes", ",", "we", "established", "11", "C0206526#ent", "<e1>", "variants", "from", "six", "ovarian", "cancer", "cell", "lines", "continuous", "exposure", "to", "paclitaxel", "or", "C0246415#ent", "<e2>", "."], "h": {"id": "C0206526", "name": "C0206526#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0246415", "name": "C0246415#ent", "pos": [28, 29]}}
{"token": ["By", "electron", "microscopic", "studies", "collagenase", "C1615665#ent", "<e1>", ",", "HCl", ",", "ascorbic", "acid", "and", "C1166521#ent", "<e2>", "been", "found", "to", "attack", "the", "collagen", "fibers", "bovine", "vitreous", "."], "h": {"id": "C1615665", "name": "C1615665#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1166521", "name": "C1166521#ent", "pos": [13, 14]}}
{"token": ["The", "cytosol", "from", "A.", "actinomycetemcomitans-infected", "J774.1", "cells", "induced", "C1705628#ent", "<e1>", "proteolysis", "in", "vitro", "which", "was", "inhibited", "by", "the", "C0291573#ent", "<e2>", "Z-DEVD-FMK", "."], "h": {"id": "C1705628", "name": "C1705628#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [18, 19]}}
{"token": ["It", "is", "classified", "as", "a", "MAP", "subspecies", "from", "MAP1", ",", "C1424480#ent", "<e1>", ",", "tau", ",", "and", "C1417017#ent", "<e2>", ",", "as", "judged", "from", "its", "electrophoretic", "mobility", "heat", "stability", "immunoreactivity", "."], "h": {"id": "C1424480", "name": "C1424480#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417017", "name": "C1417017#ent", "pos": [16, 17]}}
{"token": ["Here", ",", "we", "demonstrate", "that", "C1418946#ent", "<e1>", "-", "2", "is", "the", "C0597298#ent", "<e2>", "expressed", "on", "hematopoietic", "stem", "cells", "from", "fetal", "liver", ",", "bone", "marrow", "and", "peripheral", "blood"], "h": {"id": "C1418946", "name": "C1418946#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [11, 12]}}
{"token": ["Medications", "used", "to", "treat", "respiratory", "diseases", "C0001644#ent", "<e1>", ",", "antimuscarinics", ",", "inhaled", "and", "C0304604#ent", "<e2>", "and", "theophyllines", "."], "h": {"id": "C0001644", "name": "C0001644#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0304604", "name": "C0304604#ent", "pos": [13, 14]}}
{"token": ["Semiquantitative", "evaluation", "of", "pathologic", "changes", "the", "small", "intestine", "a", "target", "of", "C0057671#ent", "<e1>", ",", "indicated", "partial", "protection", "by", "C0596005#ent", "<e2>", "anguidine", "toxicity", "that", "site", "."], "h": {"id": "C0057671", "name": "C0057671#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0596005", "name": "C0596005#ent", "pos": [18, 19]}}
{"token": ["A", "risk", "profile", "score", "for", "C0497169#ent", "<e1>", "was", "developed", "and", "the", "contribution", "of", "C0001962#ent", "<e2>", "and", "drug", "use", "C0497169#ent", "<e1>", "risk", "was", "determined", "."], "h": {"id": "C0497169", "name": "C0497169#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0001962", "name": "C0001962#ent", "pos": [13, 14]}}
{"token": ["The", "response", "of", "the", "C1447747#ent", "<e1>", "was", "also", "attenuated", "after", "previous", "treatment", "with", "C0039542#ent", "<e2>", "in", "vivo"], "h": {"id": "C1447747", "name": "C1447747#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039542", "name": "C0039542#ent", "pos": [13, 14]}}
{"token": ["Plasma", "prednisolone", "levels", "have", "been", "compared", "in", "healthy", "volunteers", "in", "patients", "suffering", "from", "idiopathic", "proctocolitis", "the", "administration", "of", "standard", "retention", "enemata", "containing", "either", "C1882444#ent", "<e1>", "or", "prednisolone", "C0889299#ent", "<e2>"], "h": {"id": "C1882444", "name": "C1882444#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0889299", "name": "C0889299#ent", "pos": [27, 28]}}
{"token": ["Importantly", ",", "this", "phenotype", "was", "reversible", "(", "i.e.", ",", "discontinuation", "of", "Dox", "treatment", "led", "to", "C1705861#ent", "<e1>", "re-expression", "and", "remission", "of", "C0011849#ent", "<e2>", "symptoms", ")", "."], "h": {"id": "C1705861", "name": "C1705861#ent", "pos": [15, 16]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [21, 22]}}
{"token": ["Co-expression", "of", "C1415298#ent", "<e1>", "and", "a", "C0949684#ent", "<e2>", "validated", "using", "an", "isoform", "specific", "anti-nonmuscle", "myosin", "II-B", "heavy", "chain", "NMHC", "II-B", ")", "antibody", "."], "h": {"id": "C1415298", "name": "C1415298#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0949684", "name": "C0949684#ent", "pos": [6, 7]}}
{"token": ["In", "contrast", ",", "inhibition", "of", "protein", "export", "apical", "recycling", "endosomes", "upon", "expression", "of", "dominant-negative", "constructs", "of", "C1417566#ent", "<e1>", "Sec15", "selectively", "perturbed", "apical", "delivery", "C1413205#ent", "<e2>", "."], "h": {"id": "C1417566", "name": "C1417566#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1413205", "name": "C1413205#ent", "pos": [23, 24]}}
{"token": ["The", "v-erbA", "oncogene", "isolated", "from", "a", "retrovirus", "which", "contains", ",", "in", "addition", "to", "v-erbA", ",", "the", "oncogene", "v-erbB.", "The", "C0242984#ent", "<e1>", "an", "EGF-receptor", "derivative", ",", "which", "is", "a", "constitutively", "active", "C1421249#ent", "<e2>"], "h": {"id": "C0242984", "name": "C0242984#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [30, 31]}}
{"token": ["B.S.P.", ")", "for", "C0220701#ent", "<e1>", ",", "and", "to", "Cladonia-Kalmia-black", "spruce", "for", "types", "C1826492#ent", "<e2>", "and", "RP3", "."], "h": {"id": "C0220701", "name": "C0220701#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1826492", "name": "C1826492#ent", "pos": [12, 13]}}
{"token": ["C3536840#ent", "<e1>", "gene-1", "(", "NAG-1", ")", "is", "a", "C1333196#ent", "<e2>", "associated", "with", "pro-apoptotic", "and", "anti-tumorigenic", "properties", "."], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [8, 9]}}
{"token": ["Multiple", "endocrine", "neoplasia", "type", "1", "MEN", "1", ")", "represents", "an", "C1333387#ent", "<e1>", "characterized", "by", "C0032002#ent", "<e2>", "parathyroid", "and", "pancreatic", "neoplasia"], "h": {"id": "C1333387", "name": "C1333387#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032002", "name": "C0032002#ent", "pos": [14, 15]}}
{"token": ["Predictive", "quantitative", "structure-toxicity", "and", "toxicophore", "models", "were", "developed", "for", "a", "diverse", "series", "of", "C2985407#ent", "<e1>", "acting", "as", "C0003195#ent", "<e2>", "QSAR+", "module", "in", "Cerius2", "and", "HypoGen", "module", "in", "Catalyst", "software", "respectively", "."], "h": {"id": "C2985407", "name": "C2985407#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0003195", "name": "C0003195#ent", "pos": [17, 18]}}
{"token": ["Three", "sites", "were", "excavated", ",", "two", "in", "Kibish", "Member", "I", "(", "KHS", "and", "C0205710#ent", "<e1>", ")", "and", "one", "at", "the", "base", "of", "Member", "III", "C0099085#ent", "<e2>", ")", "."], "h": {"id": "C0205710", "name": "C0205710#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0099085", "name": "C0099085#ent", "pos": [24, 25]}}
{"token": ["The", "chemokine", "receptor", "C1332823#ent", "<e1>", "is", "rapidly", "targeted", "for", "lysosomal", "degradation", "the", "C0077678#ent", "<e2>", "AIP4", ")", "."], "h": {"id": "C1332823", "name": "C1332823#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0077678", "name": "C0077678#ent", "pos": [12, 13]}}
{"token": ["C1414315#ent", "<e1>", "mutation", "is", "rare", "cause", "of", "C0270911#ent", "<e2>", "in", "Japan", "as", "in", "other", "nations", "."], "h": {"id": "C1414315", "name": "C1414315#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0270911", "name": "C0270911#ent", "pos": [7, 8]}}
{"token": ["and", "suggest", "that", "the", "sex", "differences", "schizophrenia", "may", "also", "be", "due", "to", "an", "action", "of", "C2936882#ent", "<e1>", "mediated", "by", "way", "of", "C1708300#ent", "<e2>"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1708300", "name": "C1708300#ent", "pos": [21, 22]}}
{"token": ["In", "addition", ",", "INSL3", "and", "C1424771#ent", "<e1>", "found", "to", "be", "specific", "ligands", "for", "C1424898#ent", "<e2>", "and", "LGR7", ",", "respectively", "."], "h": {"id": "C1424771", "name": "C1424771#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1424898", "name": "C1424898#ent", "pos": [13, 14]}}
{"token": ["Overexpression", "of", "ODC", "increased", "the", "expression", "of", "Cyclin", "A", "D", ",", "E", "and", "Cdk4", "and", "the", "enzyme", "activity", "C0080054#ent", "<e1>", "and", "Cdk2", "after", "the", "treatment", "of", "C0733688#ent", "<e2>", "and", "TAX", ",", "respectively", "."], "h": {"id": "C0080054", "name": "C0080054#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0733688", "name": "C0733688#ent", "pos": [26, 27]}}
{"token": ["PCP", ",", "dextrorphan", ",", "C0011816#ent", "<e1>", ",", "(+)-", "and", "(-)-MK-801", "decreased", "rates", "of", "lever", "C3640016#ent", "<e2>", "and", "increased", "errors", "in", "both", "components", "of", "the", "multiple", "acquisition", ",", "performance", "schedule"], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3640016", "name": "C3640016#ent", "pos": [14, 15]}}
{"token": ["Elevated", "IgE", "levels", "hallmark", "the", "C1423842#ent", "<e1>", "to", "TH2", "switch", "occurring", "in", "advanced", "infection", "such", "an", "unbalanced", "C1333196#ent", "<e2>", "network", "may", "affect", "the", "IgG", "subclass", "production", "."], "h": {"id": "C1423842", "name": "C1423842#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1333196", "name": "C1333196#ent", "pos": [17, 18]}}
{"token": ["Stimulated", "platelets", "of", "C1527037#ent", "<e1>", "rats", "exhibited", "a", "decreased", "production", "of", "cyclooxygenase", "and", "C0023837#ent", "<e2>", "particularly", "after", "8", "weeks", "of", "diet", "."], "h": {"id": "C1527037", "name": "C1527037#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0023837", "name": "C0023837#ent", "pos": [13, 14]}}
{"token": ["We", "sought", "to", "evaluate", "the", "performance", "of", "new", "markers", ":", "brachyury", ",", "SOX-9", ",", "and", "C3537357#ent", "<e1>", "alongside", "the", "more", "traditional", "markers", "C1415042#ent", "<e2>", "carcinoembryonic", "antigen", "CD24", ",", "and", "epithelial", "membrane", "antigen"], "h": {"id": "C3537357", "name": "C3537357#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1415042", "name": "C1415042#ent", "pos": [22, 23]}}
{"token": ["C3539645#ent", "<e1>", "activation", "after", "germinal", "vesicle", "breakdown", "leads", "to", "the", "inhibition", "of", "C0298690#ent", "<e2>", "the", "arrest", "of", "cell", "cycle", "MI", "stage"], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0298690", "name": "C0298690#ent", "pos": [12, 13]}}
{"token": ["Incubation", "of", "the", "NR", "cells", "with", "either", "form", "of", "C1522455#ent", "<e1>", "resulted", "in", "its", "binding", "to", "cell-surface", "FGF", "receptors", "activation", "of", "C0752312#ent", "<e2>", "MAP", ")", "kinase", ",", "and", "induction", "of", "c-fos", "and", "c-myc", "."], "h": {"id": "C1522455", "name": "C1522455#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [21, 22]}}
{"token": ["Experiments", "indicate", "that", "C0015075#ent", "<e1>", "is", "derived", "from", "C0000975#ent", "<e2>", "or", "acids", "of", "the", "Krebs", "cycle", "acts", "by", "binding", "to", "a", "metal", "receptor", "in", "the", "tissue", "."], "h": {"id": "C0015075", "name": "C0015075#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0000975", "name": "C0000975#ent", "pos": [8, 9]}}
{"token": ["The", "high-pressure-promoted", "reaction", "of", "C3542457#ent", "<e1>", "with", "pyrazoles", "and", "C0020924#ent", "<e2>", "provided", "access", "to", "a", "variety", "of", "chiral", "diazole", "derivative", "ligands", "such", "as", "11", "-", "23", "."], "h": {"id": "C3542457", "name": "C3542457#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0020924", "name": "C0020924#ent", "pos": [9, 10]}}
{"token": ["A", "closed", ",", "ring-shaped", "conformation", "of", "C0023689#ent", "<e1>", "catalyzes", "a", "DNA", "end-joining", "reaction", "is", "strongly", "stimulated", "by", "C1366837#ent", "<e2>", "."], "h": {"id": "C0023689", "name": "C0023689#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [17, 18]}}
{"token": ["In", "contrast", ",", "photoaging", "increased", "the", "UV", "inducibility", "of", "C0087140#ent", "<e1>", "but", "decreased", "the", "baseline", "expression", "of", "the", "C3888243#ent", "<e2>", "IL-1", "receptor", "antagonist", "SPR2", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3888243", "name": "C3888243#ent", "pos": [18, 19]}}
{"token": ["Analysis", "of", "TGR", "mutants", "revealed", "that", "the", "glutaredoxin", "domain", "required", "for", "the", "C1705401#ent", "<e1>", "activity", "but", "did", "not", "affect", "the", "C0040961#ent", "<e2>", "activity", "."], "h": {"id": "C1705401", "name": "C1705401#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040961", "name": "C0040961#ent", "pos": [20, 21]}}
{"token": ["Urethane", "(", "1.25", "g/kg", ")", "given", "intraperitoneally", ",", "caused", "a", "progressive", "and", "significant", "rise", "in", "C1413266#ent", "<e1>", ",", "while", "C0030883#ent", "<e2>", "(", "30", "mg/kg", ")", "given", "intraperitoneally", "did", "not", "affect", "C1413266#ent", "<e1>", "."], "h": {"id": "C0030883", "name": "C0030883#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1413266", "name": "C1413266#ent", "pos": [15, 16]}}
{"token": ["We", "present", "evidence", "supporting", "a", "novel", "role", "for", "the", "C1334468#ent", "<e1>", "Mad3", "in", "the", "Shh", "pathway", "to", "regulate", "C1705027#ent", "<e2>", "expression", "and", "GNP", "proliferation", "."], "h": {"id": "C1334468", "name": "C1334468#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705027", "name": "C1705027#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "describe", "the", "localization", "and", "identification", "of", "the", "photoreceptor", "C1335077#ent", "<e1>", "as", "a", "novel", "C0277565#ent", "<e2>", "gene", "for", "adRP", "."], "h": {"id": "C1335077", "name": "C1335077#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0277565", "name": "C0277565#ent", "pos": [16, 17]}}
{"token": ["C0268579#ent", "<e1>", "presents", "in", "the", "newborn", "period", "with", "severe", "metabolic", "acidosis", "C0023380#ent", "<e2>", "."], "h": {"id": "C0268579", "name": "C0268579#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [11, 12]}}
{"token": ["C0018891#ent", "<e1>", "treated", "with", "pyrantel", "pamoate", "mebendazole", ",", "thiabendazole", ",", "C0001911#ent", "<e2>", ",", "praziquantel", "or", "niclosamide", "."], "h": {"id": "C0018891", "name": "C0018891#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001911", "name": "C0001911#ent", "pos": [10, 11]}}
{"token": ["The", "C0030956#ent", "<e1>", "binds", "to", "C2830173#ent", "<e2>", "the", "active", "site", "fills", "the", "hydrophobic", "channel", "completely", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2830173", "name": "C2830173#ent", "pos": [5, 6]}}
{"token": ["Long", "thoracic", "nerve", "injury", "to", "scapular", "winging", "common", ",", "often", "caused", "by", "closed", "trauma", "compression", ",", "stretching", ",", "traction", ",", "direct", "extrinsic", "force", ",", "penetrating", "injury", "or", "C0027813#ent", "<e1>", "such", "as", "C0221759#ent", "<e2>"], "h": {"id": "C0027813", "name": "C0027813#ent", "pos": [27, 28]}, "relation": "NA", "t": {"id": "C0221759", "name": "C0221759#ent", "pos": [31, 32]}}
{"token": ["In", "contrast", ",", "competition", "binding", "curves", "the", "antagonists", "C0174490#ent", "<e1>", ",", "thioperamide", "and", "C0006408#ent", "<e2>", "were", "not", "affected", "by", "GTPgammaS", "(10", "microM", "."], "h": {"id": "C0174490", "name": "C0174490#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006408", "name": "C0006408#ent", "pos": [13, 14]}}
{"token": ["Preliminary", "intravenous", "injection", "of", "C1421143#ent", "<e1>", "a", "dose", "of", "20", "g/kg", "to", "cats", "with", "developing", "C0010054#ent", "<e2>", "stimulation", "of", "the", "cerebrocortical", "sensorimotor", "zone", "a", "pronounced", "antiarrhythmic", "effect"], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010054", "name": "C0010054#ent", "pos": [15, 16]}}
{"token": ["It", "is", "proposed", "that", "the", "primary", "oxygen-sensing", "reaction", "may", "trigger", "the", "release", "of", "several", "C0127400#ent", "<e1>", "that", "stimulate", "adenylate", "cyclase", "a", "C3828360#ent", "<e2>", "a", "G", "protein", "the", "renal", "cell", "membrane"], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3828360", "name": "C3828360#ent", "pos": [21, 22]}}
{"token": ["We", "conclude", "that", "the", "activities", "of", "C0037039#ent", "<e1>", "can", "be", "modulated", "by", "protein", "kinase", "C", "C0031686#ent", "<e2>", "this", "may", "represent", "a", "potential", "regulatory", "mechanism", "ganglioside", "biosynthesis"], "h": {"id": "C0037039", "name": "C0037039#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [15, 16]}}
{"token": ["11", "C0004096#ent", "<e1>", "outpatients", "were", "treated", "with", "placebo", ",", "C0033798#ent", "<e2>", "+", "theophylline", "+", "hydroxyzine", ",", "C0033798#ent", "<e2>", "+", "theophylline", ",", "and", "C0033798#ent", "<e2>", "+", "hydroxyzine", ",", "orally", "t.i.d", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0033798", "name": "C0033798#ent", "pos": [9, 10]}}
{"token": ["Further", "analysis", "indicates", "a", "C0039585#ent", "<e1>", "to", "TRAIL", "resistance", "in", "C1705347#ent", "<e2>", "."], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705347", "name": "C1705347#ent", "pos": [10, 11]}}
{"token": ["Mechanistically", ",", "these", "data", "suggest", "that", "C3812730#ent", "<e1>", "binding", "results", "in", "nuclear", "retention", "the", "C3540509#ent", "<e2>", "mRNA", "and", "is", "consistent", "with", "C3812730#ent", "<e1>", "control", ",", "at", "least", "in", "part", ",", "of", "mRNA", "processing", "."], "h": {"id": "C3540509", "name": "C3540509#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3812730", "name": "C3812730#ent", "pos": [6, 7]}}
{"token": ["Other", "studies", "have", "suggested", "that", "NO", "exacerbates", "IRI", "and", "that", "C1538973#ent", "<e1>", "NOS", ")", "inhibitors", "act", "C0007209#ent", "<e2>", "."], "h": {"id": "C1538973", "name": "C1538973#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0007209", "name": "C0007209#ent", "pos": [16, 17]}}
{"token": ["Tolosa-Hunt-Syndrome", ",", "C0221058#ent", "<e1>", "blepharospasm", ",", "and", "C0314719#ent", "<e2>"], "h": {"id": "C0221058", "name": "C0221058#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0314719", "name": "C0314719#ent", "pos": [7, 8]}}
{"token": ["Because", "of", "low", "activity", "of", "C0031456#ent", "<e1>", "cystathionase", ",", "hyperphenylalaninemia", "and", "C4048705#ent", "<e2>", "tend", "to", "occur", ",", "whereas", "tyrosine", "and", "cysteine", "tend", "to", "be", "deficient", "."], "h": {"id": "C0031456", "name": "C0031456#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4048705", "name": "C4048705#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C1704944#ent", "<e1>", "appears", "to", "participate", "with", "SusR", "in", "regulation", "of", "the", "C0017337#ent", "<e2>"], "h": {"id": "C1704944", "name": "C1704944#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [13, 14]}}
{"token": ["Monoclonal", "antibodies", "mAbs", ")", "(", "C1420192#ent", "<e1>", "and", "7E12", ")", "were", "prepared", "against", "heparan", "sulfate", "proteoglycan", "C3540635#ent", "<e2>", ")", "isolated", "from", "bovine", "glomeruli", "."], "h": {"id": "C1420192", "name": "C1420192#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3540635", "name": "C3540635#ent", "pos": [16, 17]}}
{"token": ["To", "investigate", "the", "phenotype", "and", "T", "cell", "receptor", "TCR", ")", "use", "in", "peripheral", "blood", "T", "cells", "patients", "with", "C0032533#ent", "<e1>", "PMR", ")", "and", "C0039483#ent", "<e2>", "GCA", ")", "."], "h": {"id": "C0032533", "name": "C0032533#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0039483", "name": "C0039483#ent", "pos": [23, 24]}}
{"token": ["The", "purified", "material", "predominantly", "H-lysin", ",", "devoid", "of", "detectable", "T-lysin", ",", "C0054846#ent", "<e1>", "or", "gelatinase", "activity", "although", "glycerophospholipid", ":", "cholesterol", "acyltransferase", "C1415008#ent", "<e2>", ")", "activity", "was", "present", "."], "h": {"id": "C0054846", "name": "C0054846#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415008", "name": "C1415008#ent", "pos": [21, 22]}}
{"token": ["The", "contraction", "profiles", "of", "both", "C0035334#ent", "<e1>", "and", "nodule", "C0013312#ent", "<e2>", "fibroblasts", "demonstrated", "delays", "in", "the", "attainment", "of", "tensional", "homeostasis", "with", "an", "absence", "of", "a", "plateau", "phase", "by", "20", "hours", "."], "h": {"id": "C0035334", "name": "C0035334#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013312", "name": "C0013312#ent", "pos": [9, 10]}}
{"token": ["C0027103#ent", "<e1>", "XV", ",", "and", "C1429078#ent", "<e2>", "appeared", "after", "this", "group", ",", "and", "X", "appeared", "during", "the", "formative", "phases", "of", "vertebrate", "evolution"], "h": {"id": "C0027103", "name": "C0027103#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1429078", "name": "C1429078#ent", "pos": [5, 6]}}
{"token": ["The", "20S", "proteasome", "a", "multicatalytic", "protease", "complex", "exhibits", "trypsin-like", ",", "C0008742#ent", "<e1>", "and", "post-glutamyl-peptide", "hydrolytic", "activities", "associated", "with", "active", "sites", "the", "C3273872#ent", "<e2>", ",", "beta5", "and", "beta1", "subunits", ",", "respectively", "."], "h": {"id": "C0008742", "name": "C0008742#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273872", "name": "C3273872#ent", "pos": [21, 22]}}
{"token": ["Regarding", "metabolism", ",", "the", "embryos", "synthesize", "estrone", "(", "C2239387#ent", "<e1>", ")", "from", "E2", "by", "means", "of", "17beta-hydroxysteroid", "C0024544#ent", "<e2>", "."], "h": {"id": "C2239387", "name": "C2239387#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024544", "name": "C0024544#ent", "pos": [17, 18]}}
{"token": ["The", "alpha", "3", "C1334087#ent", "<e1>", "beta", ",", "and", "C0030956#ent", "<e2>", "C4c", ")", "were", "released", "into", "the", "fluid", "phase", "and", "the", "alpha", "2", "fragment", "C4d", ")", "remained", "linked", "covalently", "to", "the", "cell", "membrane", "an", "ester", "bond"], "h": {"id": "C1334087", "name": "C1334087#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [8, 9]}}
{"token": ["C1417134#ent", "<e1>", "appeared", "to", "C0017860#ent", "<e2>", "unsaturated", "fatty", "acyls", "preference", "to", "saturated", "ones"], "h": {"id": "C1417134", "name": "C1417134#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017860", "name": "C0017860#ent", "pos": [4, 5]}}
{"token": ["RBM", "and", "C1421207#ent", "<e1>", "are", "Y-specifically", "conserved", "in", "simians", ",", "whereas", "C1539219#ent", "<e2>", "can", "not", "be", "detected", "on", "the", "Y", "chromosomes", "New", "World", "monkeys"], "h": {"id": "C1421207", "name": "C1421207#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539219", "name": "C1539219#ent", "pos": [11, 12]}}
{"token": ["Men", "with", "bothersome", "LUTS/BPH", "often", "present", "with", "various", "other", "age-related", "conditions", ",", "including", "sexual", "dysfunction", "C0018799#ent", "<e1>", "hypertension", ",", "diabetes", ",", "and", "the", "C0524620#ent", "<e2>", "which", "can", "complicate", "management", "decisions", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [15, 16]}, "relation": "related_to", "t": {"id": "C0524620", "name": "C0524620#ent", "pos": [23, 24]}}
{"token": ["To", "investigate", "the", "phenomenon", "further", ",", "human", "C1412179#ent", "<e1>", "ADA", ")", "expression", "was", "monitored", "in", "C1516876#ent", "<e2>", "modified", "skin", "fibroblasts", "transplanted", "in", "beagle", "dogs"], "h": {"id": "C1412179", "name": "C1412179#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [15, 16]}}
{"token": ["In", "the", "frequency", "domain", "analysis", "the", "C1538440#ent", "<e1>", "component", "of", "the", "C0238288#ent", "<e2>", "group", "was", "significantly", "lower", "than", "that", "of", "the", "control", "group"], "h": {"id": "C1538440", "name": "C1538440#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0238288", "name": "C0238288#ent", "pos": [11, 12]}}
{"token": ["The", "patient's", "C0019655#ent", "<e1>", "resolved", "with", "C0064113#ent", "<e2>", "monotherapy", "."], "h": {"id": "C0019655", "name": "C0019655#ent", "pos": [2, 3]}, "relation": "may_be_treated_by", "t": {"id": "C0064113", "name": "C0064113#ent", "pos": [6, 7]}}
{"token": ["Cells", "grown", "on", "ethanol-acetate-yeast", "extract", "or", "succinate-yeast", "extract", "were", "added", "to", "a", "medium", "containing", "ethanol", "or", "C0220918#ent", "<e1>", ",", "and", "the", "C1418715#ent", "<e2>", "of", "each", "enzyme", "was", "followed", "."], "h": {"id": "C0220918", "name": "C0220918#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1418715", "name": "C1418715#ent", "pos": [21, 22]}}
{"token": ["When", "a", "method", "specific", "for", "C1875400#ent", "<e1>", "amino-terminal", "tryptic", "peptides", "from", "proteins", "is", "applied", "to", "C1419385#ent", "<e2>", ",", "peptide", "T1", "demonstrated", "to", "be", "the", "amino-terminal", "peptide", "of", "rhodopsin", "."], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419385", "name": "C1419385#ent", "pos": [15, 16]}}
{"token": ["C1947941#ent", "<e1>", "and", "reverse", "transcriptase", "genes", "many", "mutations", "that", "were", "due", "to", "C0003451#ent", "<e2>"], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003451", "name": "C0003451#ent", "pos": [12, 13]}}
{"token": ["The", "enzyme", "was", "separated", "completely", "from", "C0031653#ent", "<e1>", "and", "significantly", "from", "C0017723#ent", "<e2>"], "h": {"id": "C0031653", "name": "C0031653#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0017723", "name": "C0017723#ent", "pos": [11, 12]}}
{"token": ["C1412131#ent", "<e1>", "contains", "two", "C2717970#ent", "<e2>", "located", "in", "position", "12", "and", "17", ",", "both", "inside", "the", "catalytic", "pocket", "this", "is", "a", "unique", "feature", "of", "C1412131#ent", "<e1>", "among", "all", "protein", "tyrosine", "phosphatases"], "h": {"id": "C1412131", "name": "C1412131#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [4, 5]}}
{"token": ["The", "data", "confirm", "previous", "observations", "that", "abnormal", "hip", "morphology", "C0022408#ent", "<e1>", "and", "is", "not", "secondary", "to", "the", "C0029408#ent", "<e2>"], "h": {"id": "C0022408", "name": "C0022408#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0029408", "name": "C0029408#ent", "pos": [17, 18]}}
{"token": ["The", "N-terminal", "domain", "of", "the", "C1418946#ent", "<e1>", "similarity", "with", "HGS", "(", "hepatocyte", "growth", "C1366514#ent", "<e2>", "and", "STAM", "(", "signal-transducing", "adaptor", "molecule", ",", "which", "are", "associated", "with", "vesicular", "trafficking", "the", "endosome", "."], "h": {"id": "C1418946", "name": "C1418946#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1366514", "name": "C1366514#ent", "pos": [13, 14]}}
{"token": ["Inactivated", "EBOV", "also", "effected", "increased", "C1705952#ent", "<e1>", "expression", "in", "C1456357#ent", "<e2>", ",", "suggesting", "that", "the", "TNF", "receptor", "superfamily", "be", "involved", "in", "apoptosis", "of", "the", "host", "lymphoid", "cells", "and", "that", "induction", "may", "occur", "independent", "of", "viral", "replication"], "h": {"id": "C1705952", "name": "C1705952#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1456357", "name": "C1456357#ent", "pos": [9, 10]}}
{"token": ["Stimulation", "of", "platelets", "by", "the", "ionophore", "A23187", "in", "the", "presence", "of", "C1414518#ent", "<e1>", "induced", "a", "C0006784#ent", "<e2>", "dependent", "cleavage", "of", "SHP-1", "."], "h": {"id": "C1414518", "name": "C1414518#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0006784", "name": "C0006784#ent", "pos": [15, 16]}}
{"token": ["C0009326#ent", "<e1>", "become", "a", "less", "common", "cause", "of", "pure", "C0003504#ent", "<e2>", "and", "a", "number", "of", "etiologies", "primarily", "involving", "the", "wall", "of", "the", "aorta", "are", "now", "recognized", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003504", "name": "C0003504#ent", "pos": [9, 10]}}
{"token": ["By", "means", "of", "a", "case-control", "study", "investigated", "the", "association", "between", "HLA", "phenotypes", "and", "the", "development", "of", "proteinuria", "after", "C0018033#ent", "<e1>", "or", "D-penicillamine", "treatment", "in", "patients", "with", "C0003873#ent", "<e2>", "RA", ")", "."], "h": {"id": "C0018033", "name": "C0018033#ent", "pos": [18, 19]}, "relation": "may_treat", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [26, 27]}}
{"token": ["Homogentisate", "is", "then", "catabolized", "by", "a", "central", "catabolic", "pathway", "involves", "three", "enzymes", ",", "homogentisate", "dioxygenase", "C1333907#ent", "<e1>", ")", ",", "fumarylacetoacetate", "hydrolase", "HmgB", ")", ",", "and", "C0065576#ent", "<e2>", "HmgC", ")", ",", "finally", "yielding", "fumarate", "and", "acetoacetate", "."], "h": {"id": "C1333907", "name": "C1333907#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0065576", "name": "C0065576#ent", "pos": [25, 26]}}
{"token": ["The", "activity", "was", "inhibited", "strongly", "by", "DFP", "or", "C0055676#ent", "<e1>", "and", "only", "partially", "by", "HgCl2", "or", "C0008249#ent", "<e2>", "."], "h": {"id": "C0055676", "name": "C0055676#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0008249", "name": "C0008249#ent", "pos": [16, 17]}}
{"token": ["Considering", "C0720099#ent", "<e1>", "of", "incapacity", "for", "work", "and", "its", "repeatability", ",", "C3241938#ent", "<e2>", "seem", "to", "be", "the", "most", "relevant", "health", "problem", "employees", "in", "heavy", "industry", "and", "especially", "in", "women", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3241938", "name": "C3241938#ent", "pos": [11, 12]}}
{"token": ["To", "explore", "the", "prevalence", "of", "C2711227#ent", "<e1>", "neonatal", "intrahepatic", "cholestasis", "by", "C1863844#ent", "<e2>", "NICCD", ")", "in", "Taiwanese", "infants", "with", "idiopathic", "intrahepatic", "cholestasis"], "h": {"id": "C2711227", "name": "C2711227#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C1863844", "name": "C1863844#ent", "pos": [11, 12]}}
{"token": ["In", "vitro", "assays", "demonstrated", "that", "both", "S10", "and", "C3539697#ent", "<e1>", "bind", "to", "C0919521#ent", "<e2>", "specifically", "and", "that", "C0919521#ent", "<e2>", "can", "be", "co-immunoprecipitated", "with", "S10", "and", "C3539697#ent", "<e1>", "from", "transfected", "cells", "."], "h": {"id": "C0919521", "name": "C0919521#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3539697", "name": "C3539697#ent", "pos": [8, 9]}}
{"token": ["If", "the", "C0271408#ent", "<e1>", "was", "placed", "on", "RPE", "cells", "cultured", "in", "monolayer", "instead", "of", "placing", "the", "cells", "on", "the", "C0271408#ent", "<e1>", ",", "keratin", "and", "vimentin", "were", "expressed", "these", "C1413980#ent", "<e1>", "with", "time", "."], "h": {"id": "C0271408", "name": "C0271408#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1413980", "name": "C1413980#ent", "pos": [28, 29]}}
{"token": ["Haematological", "toxicity", "moderate", ",", "other", "than", "in", "two", "patients", ",", "one", "of", "whom", "developed", "C0175816#ent", "<e1>", "the", "other", "C0040034#ent", "<e2>", "."], "h": {"id": "C0175816", "name": "C0175816#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [18, 19]}}
{"token": ["Temporary", "splenomegaly", "was", "noted", "also", "in", "two", "children", "with", "varicella", "(", "one", "of", "whom", "also", "had", "C0038395#ent", "<e1>", "and", "in", "an", "adult", "with", "probable", "C0035920#ent", "<e2>", "."], "h": {"id": "C0038395", "name": "C0038395#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0035920", "name": "C0035920#ent", "pos": [24, 25]}}
{"token": ["In", "C3714642#ent", "<e1>", "replete", "rats", ",", "intraoral", "infusions", "C3811061#ent", "<e2>", "elicited", "a", "mixed", "response", "of", "a", "similar", "number", "of", "ingestive", "and", "aversive", "responses", "following", "i.c.v", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3811061", "name": "C3811061#ent", "pos": [8, 9]}}
{"token": ["A", "number", "of", "drug", "resistance", ",", "whose", "products", "include", "mutant", "forms", "of", "C3541394#ent", "<e1>", "that", "confer", "resistance", "to", "C0033978#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033978", "name": "C0033978#ent", "pos": [18, 19]}}
{"token": ["C0016719#ent", "<e1>", "a", "rare", "disorder", "of", "C0007760#ent", "<e2>", "is", "inherited", "dominantly", "and", "has", "a", "benign", "prognosis", "."], "h": {"id": "C0016719", "name": "C0016719#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0007760", "name": "C0007760#ent", "pos": [6, 7]}}
{"token": ["Hyperornithinemia", ",", "hyperammonemia", "and", "homocitrullinuria", "(", "C0268540#ent", "<e1>", ")", "syndrome", "presents", "with", "various", "neurological", "symptoms", "including", "mental", "retardation", "C0037771#ent", "<e2>", "pyramidal", "signs", ",", "cerebellar", "ataxia", "and", "episodic", "disturbance", "consciousness", "or", "coma", "caused", "by", "hyperammonemia", "."], "h": {"id": "C0268540", "name": "C0268540#ent", "pos": [6, 7]}, "relation": "has_manifestation", "t": {"id": "C0037771", "name": "C0037771#ent", "pos": [18, 19]}}
{"token": ["The", "aim", "of", "this", "study", "was", "to", "investigate", "the", "long-term", "effects", "on", "bone", "mineral", "density", "C1826421#ent", "<e1>", ")", "and", "bone", "turnover", "various", "C0102118#ent", "<e2>", "treatment", "withdrawal", "."], "h": {"id": "C1826421", "name": "C1826421#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0102118", "name": "C0102118#ent", "pos": [22, 23]}}
{"token": ["These", "findings", "include", "(", "i", ")", "blockage", "of", "the", "transforming", "activity", "constitutively", "active", "C1421249#ent", "<e1>", "inhibiting", "ras", "function", "(", "ii", ")", "genetic", "screens", "Caenorhabditis", "elegans", "in", "Drosophila", "that", "identified", "C1705572#ent", "<e2>", "downstream", "effectors", "of", "C1421249#ent", "<e1>"], "h": {"id": "C1705572", "name": "C1705572#ent", "pos": [29, 30]}, "relation": "NA", "t": {"id": "C1421249", "name": "C1421249#ent", "pos": [13, 14]}}
{"token": ["The", "serum", "C0016424#ent", "<e1>", "concentration", "was", "statistically", "significantly", "in", "the", "ERT", "group", "(", "Group", "I", "and", "a", "statistically", "significant", "correlation", "between", "C0016424#ent", "<e1>", "level", "and", "average", "C0917713#ent", "<e1>", "(", "Lmean", ")", "was", "present", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0917713", "name": "C0917713#ent", "pos": [26, 27]}}
{"token": ["Aspartase", "(", "l-aspartate", "ammonia-lyase", "C3887563#ent", "<e1>", ",", "which", "catalyzes", "the", "reversible", "deamination", "of", "l-aspartic", "acid", "yield", "C0060825#ent", "<e2>", "ammonia", ",", "is", "highly", "selective", "towards", "l-aspartic", "acid"], "h": {"id": "C3887563", "name": "C3887563#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0060825", "name": "C0060825#ent", "pos": [16, 17]}}
{"token": ["Thus", ",", "C0017245#ent", "<e1>", "reduced", "thrombin", "generation", "men", "with", "combined", "C0700623#ent", "<e2>", ",", "without", "influencing", "the", "plasma", "levels", "of", "fibrinogen", ",", "VIIa", "and", "XIIa", ",", "or", "fibrin", "gel", "structure", "."], "h": {"id": "C0017245", "name": "C0017245#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700623", "name": "C0700623#ent", "pos": [10, 11]}}
{"token": ["Also", ",", "DADLE", "at", "1", "pM", "selectively", "increases", "c-Jun", "and", "C0087140#ent", "<e1>", ",", "but", "not", "C1704703#ent", "<e2>", "."], "h": {"id": "C0087140", "name": "C0087140#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1704703", "name": "C1704703#ent", "pos": [15, 16]}}
{"token": ["A", "total", "of", "3", "C3146244#ent", "<e1>", ",", "18", "TRBJ", "and", "3", "substantially", "identical", "TRBC", "C1417679#ent", "<e2>", "were", "identified", "in", "about", "28", "kb", "."], "h": {"id": "C3146244", "name": "C3146244#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [14, 15]}}
{"token": ["In", "this", "report", ",", "longitudinal", "genetic", "changes", "C0028326#ent", "<e1>", "and", "VP1", "gene", "of", "B19", "C1875400#ent", "<e2>", "from", "three", "AIDS", "patients", "with", "persistent", "B19", "infection", "studied", "."], "h": {"id": "C0028326", "name": "C0028326#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [14, 15]}}
{"token": ["Further", ",", "close", "inter-correlations", "exist", "between", "QUIN", "C0022816#ent", "<e1>", "L-kynurenine", "with", "both", "C1412709#ent", "<e2>", "neopterin", "in", "CSF", "and", "serum", "."], "h": {"id": "C0022816", "name": "C0022816#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412709", "name": "C1412709#ent", "pos": [12, 13]}}
{"token": ["It", "may", "be", "concluded", "that", "astrocytes", "play", "an", "important", "role", "supplying", "neurons", "with", "precursors", "for", "biosynthesis", "of", "C0017789#ent", "<e1>", "and", "GABA", "such", "as", "glutamine", "and", "C1415587#ent", "<e2>", "cycle", "constituents", "."], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1415587", "name": "C1415587#ent", "pos": [25, 26]}}
{"token": ["C1700874#ent", "<e1>", "is", "an", "oral", "inhibitor", "the", "VEGF", ",", "PDGF", "and", "C0879468#ent", "<e2>", "is", "currently", "in", "development", "by", "Pfizer", "Inc", "for", "the", "potential", "treatment", "of", "various", "solid", "tumors"], "h": {"id": "C1700874", "name": "C1700874#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0879468", "name": "C0879468#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "recombinant", "LIP4", "had", "higher", "C0014894#ent", "<e1>", "activities", "toward", "long-chain", "ester", "lower", "lipase", "activities", "C0023764#ent", "<e2>", ",", "triolein", ",", "and", "olive", "oil"], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0023764", "name": "C0023764#ent", "pos": [16, 17]}}
{"token": ["Helicobacter", "pylori", "the", "most", "important", "etiologic", "factor", "gastritis", "and", "C0030920#ent", "<e1>", "has", "recently", "been", "associated", "with", "C0012242#ent", "<e2>"], "h": {"id": "C0030920", "name": "C0030920#ent", "pos": [9, 10]}, "relation": "related_to", "t": {"id": "C0012242", "name": "C0012242#ent", "pos": [16, 17]}}
{"token": ["Chloramphenicol", "resistance", "was", "due", "to", "the", "C1333663#ent", "<e1>", "all", "the", "chloramphenicol", "resistant", "C1875400#ent", "<e2>", "."], "h": {"id": "C1333663", "name": "C1333663#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [12, 13]}}
{"token": ["Low-threshold", "intervention", "programmes", "may", "reduce", "both", "the", "individual", "and", "societal", "burden", "of", "C0917801#ent", "<e1>", ",", "coexisting", "with", "or", "without", "other", "mental", "or", "C0683323#ent", "<e2>"], "h": {"id": "C0917801", "name": "C0917801#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0683323", "name": "C0683323#ent", "pos": [22, 23]}}
{"token": ["In", "a", "global", "screen", "transcriptional", "targets", "of", "Fgf10", ",", "we", "identified", "C0054869#ent", "<e1>", "cathepsin", "H", ",", "a", "gene", "encoding", "a", "C1667078#ent", "<e2>", "the", "papain", "family", "highly", "up-regulated", "in", "the", "developing", "lung", "epithelium"], "h": {"id": "C0054869", "name": "C0054869#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1667078", "name": "C1667078#ent", "pos": [20, 21]}}
{"token": ["X-linked", "congenital", "stationary", "night", "blindness", "CSNB", ")", "is", "a", "C0017361#ent", "<e1>", "non-progressive", "retinal", "disorder", "by", "night", "blindness", "decreased", "visual", "acuity", "C0027092#ent", "<e2>", ",", "nystagmus", "and", "strabismus", "."], "h": {"id": "C0017361", "name": "C0017361#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027092", "name": "C0027092#ent", "pos": [20, 21]}}
{"token": ["Here", ",", "we", "identify", "the", "C0031727#ent", "<e1>", "responsible", "for", "S10", "phosphorylation", "C0539636#ent", "<e2>", "stathmin", "(", "hKIS", ")", "and", "show", "that", "it", "regulates", "cell", "cycle", "progression"], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [5, 6]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0539636", "name": "C0539636#ent", "pos": [11, 12]}}
{"token": ["The", "reported", "therapeutic", "success", "rate", "(", "95", "%", ")", "and", "bacteriological", "analysis", "confirmed", "the", "effectiveness", "of", "C0008809#ent", "<e1>", "in", "subjects", "with", "bacterial", "conjunctivitis", "C0009768#ent", "<e2>"], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0009768", "name": "C0009768#ent", "pos": [23, 24]}}
{"token": ["The", "current", "study", "examines", "the", "stimulation", "of", "healing", "processes", "and", "signal", "transduction", "is", "mediated", "by", "insulin-like", "growth", "factor-I", "C1334089#ent", "<e1>", ")", "in", "an", "ex", "vivo", "esophageal", "explant", "when", "using", "C0213654#ent", "<e2>", "inhibition", "of", "receptor", "tyrosine", "kinase"], "h": {"id": "C1334089", "name": "C1334089#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0213654", "name": "C0213654#ent", "pos": [29, 30]}}
{"token": ["However", ",", "overexpression", "of", "C3272498#ent", "<e1>", "resulted", "in", "increased", "NF-kappaB", "activity", "rendered", "C1424252#ent", "<e2>", "resistant", "to", "ATO-induced", "apoptosis", "."], "h": {"id": "C3272498", "name": "C3272498#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1424252", "name": "C1424252#ent", "pos": [12, 13]}}
{"token": ["In", "spite", "of", "the", "absence", "of", "C0017536#ent", "<e1>", ",", "treatment", "with", "C0025872#ent", "<e2>", "produced", "objective", "clinical", "improvement", "biological", "signs", "healing", "of", "the", "malabsorption", "syndrome", "but", "no", "alteration", "in", "the", "agammaglobulinemia", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [11, 12]}}
{"token": ["The", "delayed", "activation", "of", "C3889721#ent", "<e1>", "derives", "from", "an", "upregulated", "mRNA", "and", "protein", "expression", "is", "due", "to", "increased", "C3889721#ent", "<e1>", "promoter", "activity", "mechanistically", "involves", "C1705050#ent", "<e1>", "activation", "as", "well", "as", "protein", "kinase", "C", "the", "classical", "mitogen-activated", "protein", "kinases"], "h": {"id": "C3889721", "name": "C3889721#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705050", "name": "C1705050#ent", "pos": [24, 25]}}
{"token": ["In", "this", "review", ",", "recent", "findings", "concerning", "the", "adrenocortical", "function", "radiological", "changes", "in", "adrenal", "glands", "C1367469#ent", "<e1>", "axis", "involvement", "in", "C0041323#ent", "<e2>", "are", "discussed", "."], "h": {"id": "C1367469", "name": "C1367469#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0041323", "name": "C0041323#ent", "pos": [20, 21]}}
{"token": ["C0027947#ent", "<e1>", "produced", "by", "injections", "of", "antineutrophil", "serum", "C1161438#ent", "<e2>", "failed", "to", "inhibit", "activation", "of", "DNA", "synthesis", "fibroblasts", "or", "endothelial", "cells"], "h": {"id": "C0027947", "name": "C0027947#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1161438", "name": "C1161438#ent", "pos": [8, 9]}}
{"token": ["In", "the", "clinical", "picture", "C1457887#ent", "<e1>", "was", "predominant", "including", ":", "C0238637#ent", "<e2>", ",", "vertigo", ",", "feeling", "of", "fatigue", "after", "work", ",", "difficulties", "with", "attention", "concentration", "memorizing", ",", "paresthesia", "."], "h": {"id": "C1457887", "name": "C1457887#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0238637", "name": "C0238637#ent", "pos": [10, 11]}}
{"token": ["The", "dosage", "of", "C0004057#ent", "<e1>", "was", "30", "mg/kg", "orally", "during", "the", "C0015967#ent", "<e2>", "5", "-", "10", "mg/kg", "orally", "after", "lysis", "of", "fever", "."], "h": {"id": "C0004057", "name": "C0004057#ent", "pos": [3, 4]}, "relation": "may_treat", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [11, 12]}}
{"token": ["Today", ",", "some", "postgenomic", "biotechnologies", "such", "as", "transcriptome", "analyses", "allow", "characterization", "of", "the", "full", "expressed", "C0017337#ent", "<e1>", "involved", "in", "the", "majority", "of", "C0003047#ent", "<e2>", "genetic", "control"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003047", "name": "C0003047#ent", "pos": [22, 23]}}
{"token": ["In", "this", "study", "we", "compared", "platelet", "serotonin", "concentration", "in", "95", "patients", "with", "C1413792#ent", "<e1>", ",", "166", "patients", "with", "C0149931#ent", "<e2>", "and", "35", "normal", "control", "."], "h": {"id": "C1413792", "name": "C1413792#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [18, 19]}}
{"token": ["The", "inactivation", "of", "C0015278#ent", "<e1>", "and", "maltose", "permease", "sporulation", "conditions", "in", "MAL", "C0669365#ent", "<e2>", "strains", "suggests", "an", "alternative", "mechanism", "for", "the", "regulation", "of", "the", "MAL", "gene", "expression", "the", "sporulation", "process", "."], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}}
{"token": ["It", "prevented", "derepression", "of", "isocitrate", "lyase", "fructose-1,6-diphosphatase", "and", "C0015278#ent", "<e1>", "in", "a", "C0669365#ent", "<e2>", "but", "glucose", "sensitive", "C0015278#ent", "<e1>", "mutant", "."], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [12, 13]}}
{"token": ["Since", "cyclins", "D/CDK2", "and", "cyclin", "A/CDK2", "phosphorylate", "pRB", ",", "C3538705#ent", "<e1>", "caused", "an", "increase", "of", "hypophosphorylated", "C1334895#ent", "<e2>", "."], "h": {"id": "C3538705", "name": "C3538705#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334895", "name": "C1334895#ent", "pos": [16, 17]}}
{"token": ["In", "carcinomas", ",", "C0795974#ent", "<e1>", "staining", "for", "all", "C0599220#ent", "<e2>", "was", "invariably", "discontinuous", "or", "absent", ",", "consistent", "with", "presence", "of", "complete", "C0795974#ent", "<e1>", "breaks", "."], "h": {"id": "C0795974", "name": "C0795974#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [8, 9]}}
{"token": ["C1335273#ent", "<e1>", "activation", "was", "independent", "of", "C1333649#ent", "<e2>", "Src", "and", "was", "dependent", "on", "Rho", "."], "h": {"id": "C1335273", "name": "C1335273#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333649", "name": "C1333649#ent", "pos": [6, 7]}}
{"token": ["C0532010#ent", "<e1>", "promotes", "binding", "of", "C3470429#ent", "<e2>", "and", "p27", "to", "CDK2", "while", "decreasing", "their", "binding", "to", "CDK6", "."], "h": {"id": "C0532010", "name": "C0532010#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3470429", "name": "C3470429#ent", "pos": [5, 6]}}
{"token": ["HPA", "involved", "another", "pathway", "resulting", "from", "the", "activity", "of", "an", "C0030016#ent", "<e1>", ",", "which", "is", "suggested", "to", "be", "responsible", "for", "both", "C0048386#ent", "<e2>", "and", "hydroxytyrosol", "oxidation"], "h": {"id": "C0030016", "name": "C0030016#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0048386", "name": "C0048386#ent", "pos": [21, 22]}}
{"token": ["Four", "neonates", "with", "vesicopustular", "skin", "eruptions", "1", "girl", "and", "3", "boys", ",", "were", "diagnosed", "with", "feeding", "blisters", "C0021100#ent", "<e1>", "erythema", "toxicum", "neonatorum", "transient", "neonatal", "C0406782#ent", "<e2>", "respectively", "."], "h": {"id": "C0021100", "name": "C0021100#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0406782", "name": "C0406782#ent", "pos": [24, 25]}}
{"token": ["The", "current", "work", "identifies", "the", "human", "mast", "cell", "chymase", "gene", "C1413516#ent", "<e1>", ")", "as", "the", "fourth", "C1947941#ent", "<e2>", "in", "this", "cluster", "and", "maps", "the", "gene", "to", "within", "150", "kb", "of", "the", "cathepsin", "G", "gene"], "h": {"id": "C1413516", "name": "C1413516#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [16, 17]}}
{"token": ["C0012963#ent", "<e1>", "therefore", "is", "a", "potent", "C0597058#ent", "<e2>", "limited", "chronotropic", "and", "peripheral", "vascular", "effects", "and", "deserves", "therapeutic", "trial", "the", "short-term", "management", "of", "low", "output", "heart", "failure"], "h": {"id": "C0012963", "name": "C0012963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597058", "name": "C0597058#ent", "pos": [6, 7]}}
{"token": ["Furthermore", ",", "both", "the", "C1706175#ent", "<e1>", "and", "the", "tum-", "peptides", "can", "bind", "to", "C1705360#ent", "<e2>", "as", "octamers", "."], "h": {"id": "C1706175", "name": "C1706175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705360", "name": "C1705360#ent", "pos": [13, 14]}}
{"token": ["Surface", "plasmon", "resonance", "appreciable", "reduction", "in", "binding", "affinity", "between", "C1413036#ent", "<e1>", "and", "VWF115", "mutants", "(", "C1839259#ent", "<e2>", "up", "to", "approximately", "1.3", "microM", ")", ",", "compared", "with", "VWF115", "(", "C1839259#ent", "<e2>", "20", "nM", ")", "."], "h": {"id": "C1413036", "name": "C1413036#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [15, 16]}}
{"token": ["C0015371#ent", "<e1>", "(", "EP", ")", "symptoms", "and", "neuropsychological", "(", "C1824810#ent", "<e2>", ")", "deficits", "are", "both", "frequently", "present", "among", "schizophrenia", "patients", "."], "h": {"id": "C0015371", "name": "C0015371#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1824810", "name": "C1824810#ent", "pos": [9, 10]}}
{"token": ["Two", "C0341703#ent", "<e1>", "potentially", "encoding", "novel", "C0527356#ent", "<e2>", "found", "in", "mec", "DNA"], "h": {"id": "C0341703", "name": "C0341703#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0527356", "name": "C0527356#ent", "pos": [6, 7]}}
{"token": ["The", "potency", "ranking", "for", "both", "veins", "was", "SQ26655", "greater", "than", "U44069", "greater", "than", "C1705889#ent", "<e1>", "greater", "than", "PGF2", "alpha", "than", "TXB2", "much", "greater", "than", "C1865138#ent", "<e2>", "."], "h": {"id": "C1705889", "name": "C1705889#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1865138", "name": "C1865138#ent", "pos": [24, 25]}}
{"token": ["Finally", ",", "basal", "C0124604#ent", "<e1>", "phosphorylation", "in", "neurons", "is", "mediated", "predominantly", "by", "C1826724#ent", "<e2>", "at", "Ser-476", ",", "with", "C1826724#ent", "<e2>", "activation", "increasing", "phosphorylation", "at", "Ser-440", "and", "enhancing", "C0124604#ent", "<e1>", "activity", "."], "h": {"id": "C0124604", "name": "C0124604#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [12, 13]}}
{"token": ["We", "have", "reported", "that", "peroxynitrite", "(", "C1418754#ent", "<e1>", ")", "selectively", "inactivated", "prostacyclin", "synthase", "C3272780#ent", "<e2>", ")", "by", "a", "mechanism", "of", "tyrosine", "nitration", "the", "active", "site", "Zou", ",", "Martin", "and", "Ullrich", "(", "1997", ")", "Biol", "."], "h": {"id": "C1418754", "name": "C1418754#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3272780", "name": "C3272780#ent", "pos": [13, 14]}}
{"token": ["Expression", "of", "the", "glycosyl-phosphatidylinositol-anchored", "molecule-like", "protein", "(", "C1415134#ent", "<e1>", ")", "gene", ",", "a", "C1705526#ent", "<e2>", "target", ",", "correlates", "with", "the", "sensitivity", "of", "some", "cancer", "cell", "lines", "anticancer", "drugs", "ionizing", "radiation"], "h": {"id": "C1415134", "name": "C1415134#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705526", "name": "C1705526#ent", "pos": [13, 14]}}
{"token": ["Therefore", ",", "we", "investigated", "the", "role", "of", "C0051874#ent", "<e1>", "the", "development", "of", "endothelial", "dysfunction", "C0020479#ent", "<e2>", "ApoE-/-", ")", "mice", "."], "h": {"id": "C0051874", "name": "C0051874#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020479", "name": "C0020479#ent", "pos": [14, 15]}}
{"token": ["We", "sought", "to", "evaluate", "the", "diagnostic", "use", "of", "multidetector", "computed", "tomography", "MDCT", ")", "cholangiography", "with", "multiplanar", "reformation", "(", "C4284033#ent", "<e1>", ")", "for", "the", "assessment", "of", "patients", "with", "C0400979#ent", "<e2>"], "h": {"id": "C4284033", "name": "C4284033#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0400979", "name": "C0400979#ent", "pos": [27, 28]}}
{"token": ["To", "evaluate", "this", "C0079429#ent", "<e1>", "in", "non-insulin-dependent", "diabetes", "mellitus", "NIDDM", ")", ",", "a", "full-length", "human", "C1705599#ent", "<e2>", "cDNA", "was", "isolated", "and", "the", "genomic", "structure", "characterized", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705599", "name": "C1705599#ent", "pos": [15, 16]}}
{"token": ["Of", "these", "isomerases", ",", "cPGES", "and", "C4082991#ent", "<e1>", "are", "constitutive", "C3540790#ent", "<e2>", ",", "whereas", "mPGES-1", "is", "mainly", "an", "induced", "isomerase", "."], "h": {"id": "C4082991", "name": "C4082991#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [10, 11]}}
{"token": ["Among", "the", "patients", "33", "%", "had", "total", "blindness", "of", "which", "03", "had", "C0029124#ent", "<e1>", "1", "has", "secondary", "C0338508#ent", "<e2>"], "h": {"id": "C0029124", "name": "C0029124#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0338508", "name": "C0338508#ent", "pos": [17, 18]}}
{"token": ["Cytochrome", "P450", "C0534137#ent", "<e1>", ")", "C3542456#ent", "<e2>", "include", "a", "family", "of", "related", "C3542456#ent", "<e2>", "that", "are", "involved", "in", "metabolism", "of", "vitamins", ",", "steroids", ",", "fatty", "acids", "and", "other", "chemicals", "."], "h": {"id": "C0534137", "name": "C0534137#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3542456", "name": "C3542456#ent", "pos": [5, 6]}}
{"token": ["C0040377#ent", "<e1>", ",", "which", "is", "an", "C0003211#ent", "<e2>", "a", "short", "half-life", "can", "provide", "adequate", ",", "safe", "therapy", "in", "the", "geriatric", "population"], "h": {"id": "C0040377", "name": "C0040377#ent", "pos": [0, 1]}, "relation": "has_structural_class", "t": {"id": "C0003211", "name": "C0003211#ent", "pos": [6, 7]}}
{"token": ["Secondly", ",", "there", "has", "been", "some", "disenchantment", "with", "the", "long", "term", "of", "regular", "beta", "2-adrenergic", "agonists", "these", "C0991617#ent", "<e1>", "do", "not", "appear", "to", "control", "C0006277#ent", "<e2>", "have", "been", "associated", "with", "deaths", "from", "asthma", "."], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0006277", "name": "C0006277#ent", "pos": [24, 25]}}
{"token": ["The", "digestibility", "was", "significantly", "higher", "LSD", "and", "C0268263#ent", "<e1>", "than", "in", "C3890918#ent", "<e2>", ",", "while", "that", "in", "LSD", "and", "C0268263#ent", "<e1>", "was", "nearly", "the", "same", "."], "h": {"id": "C3890918", "name": "C3890918#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0268263", "name": "C0268263#ent", "pos": [7, 8]}}
{"token": ["Following", "this", "region", ",", "there", "was", "an", "C1412821#ent", "<e1>", "encoded", "with", "an", "C0544482#ent", "<e2>", "of", "142", "amino", "acids"], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0544482", "name": "C0544482#ent", "pos": [12, 13]}}
{"token": ["The", "markers", "studied", "were", "C1423594#ent", "<e1>", "CA125", ")", ",", "squamous", "cell", "carcinoma", "antigen", "SCC", ")", "and", "tissue", "polypeptide", "antigen", "C0256103#ent", "<e2>", ")", "."], "h": {"id": "C1423594", "name": "C1423594#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [19, 20]}}
{"token": ["The", "most", "common", "cause", "of", "oropharyngeal", "dysphagia", "cerebrovascular", "accidents", "other", "causes", "may", "include", "oropharyngeal", "structural", "lesions", "systematic", "and", "C0027868#ent", "<e1>", "and", "diverse", "C0027765#ent", "<e2>"], "h": {"id": "C0027868", "name": "C0027868#ent", "pos": [18, 19]}, "relation": "related_to", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [22, 23]}}
{"token": ["Single-dose", "versus", "conventional", "six-day", "therapy", "with", "C0038687#ent", "<e1>", "for", "asymptomatic", "C0042029#ent", "<e2>", "pregnant", "women", "investigated", "in", "a", "prospective", ",", "randomised", "open", "study", "."], "h": {"id": "C0038687", "name": "C0038687#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0042029", "name": "C0042029#ent", "pos": [10, 11]}}
{"token": ["Individuals", "with", "C0039585#ent", "<e1>", "a", "spectrum", "of", "phenotypic", "abnormalities", "from", "complete", "C1367578#ent", "<e2>", "undervirilized", "men", "."], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [2, 3]}, "relation": "disease_has_associated_gene", "t": {"id": "C1367578", "name": "C1367578#ent", "pos": [11, 12]}}
{"token": ["Point", "mutations", "deletions", "in", "the", "androgen", "receptor", "gene", "C0039585#ent", "<e1>", "however", "subjects", "with", "C1367578#ent", "<e2>", "normal", "virilization", "although", "progressive", "gynaecomastia", ",", "testicular", "atrophy", "infertility", "may", "occur", "."], "h": {"id": "C0039585", "name": "C0039585#ent", "pos": [8, 9]}, "relation": "disease_has_associated_gene", "t": {"id": "C1367578", "name": "C1367578#ent", "pos": [13, 14]}}
{"token": ["Previously", ",", "we", "constructed", "and", "purified", "nine", "recombinant", "C4BP", "molecules", "in", "which", "solvent", "exposed", "positively", "charged", "C3539946#ent", "<e1>", "the", "interface", "between", "C1824644#ent", "<e2>", "and", "CCP2", "were", "mutated", "to", "polar", "glutamines"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1824644", "name": "C1824644#ent", "pos": [21, 22]}}
{"token": ["Downregulation", "of", "C0537086#ent", "<e1>", "increased", "necrosis", "induced", "by", "C0594375#ent", "<e2>", "in", "A549", "cells", "not", "in", "PC-14", "and", "RERF-LC-KJ", "cells", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0594375", "name": "C0594375#ent", "pos": [8, 9]}}
{"token": ["Nucleotides", "that", "enhance", "the", "activity", "of", "GlcNAc", "2-epimerases", "these", "C3541394#ent", "<e1>", "against", "degradation", "by", "C0039815#ent", "<e2>", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0039815", "name": "C0039815#ent", "pos": [14, 15]}}
{"token": ["The", "effects", "of", "ten", "metabolites", "of", "the", "branched-chain", "amino", "acids", "CoA", "and", "C0010648#ent", "<e1>", "(", "beta-mercaptoethylamine", ")", ",", "on", "the", "C0082730#ent", "<e2>", "investigated", "with", "the", "liver", "extracts"], "h": {"id": "C0010648", "name": "C0010648#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0082730", "name": "C0082730#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "differences", "exist", "between", "sensitive", "and", "resistant", "cells", "in", "the", "expression", "of", "C1538611#ent", "<e1>", "in", "the", "control", "of", "intracellular", "C3653518#ent", "<e2>", "calcium-dependent", "processes"], "h": {"id": "C1538611", "name": "C1538611#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3653518", "name": "C3653518#ent", "pos": [20, 21]}}
{"token": ["To", "investigate", "the", "value", "of", "detecting", "cytokeratin", "19(CK19", ")", "and", "thyroperoxidase", "(", "C1364508#ent", "<e1>", ")", "expression", "in", "the", "diagnosis", "of", "C0040128#ent", "<e2>", "thyroid", "carcinoma", "multinodular", "goiter", "adenoma", "and", "Hashimoto", "thyroiditis"], "h": {"id": "C1364508", "name": "C1364508#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0040128", "name": "C0040128#ent", "pos": [20, 21]}}
{"token": ["The", "following", "therapies", "were", "used", "in", "this", "group", "of", "patients", ":", "low", "molecular", "weight", "heparin", "warfarin", ",", "calcium-channel", "blockers", "aspirin", ",", "C1161438#ent", "<e1>", ",", "bosentan", ",", "iloprost", ",", "and", "C0529793#ent", "<e2>", "."], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0529793", "name": "C0529793#ent", "pos": [29, 30]}}
{"token": ["Only", "in", "cells", "overexpressing", "the", "wild-type", "liver", "PFK-2/FBPase-2", "C0597298#ent", "<e1>", "was", "the", "increase", "of", "C0017868#ent", "<e2>", "activity", "abolished", "by", "forskolin", ",", "apparently", "due", "to", "the", "regulatory", "site", "phosphorylation", "by", "a", "cAMP-dependent", "protein", "kinase"], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017868", "name": "C0017868#ent", "pos": [14, 15]}}
{"token": ["Commercially", "available", "C0055461#ent", "<e1>", "preparations", "were", "perceived", "as", "more", "effective", "than", "either", "C0003419#ent", "<e2>", "or", "herbal", "remedies", "the", "treatment", "of", "malaria", ",", "and", "injections", "were", "regarded", "as", "more", "effective", "than", "oral", "medications"], "h": {"id": "C0055461", "name": "C0055461#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003419", "name": "C0003419#ent", "pos": [12, 13]}}
{"token": ["This", "was", "originally", "demonstrated", "in", "individuals", "with", "the", "rare", "C0019247#ent", "<e1>", "xeroderma", "pigmentosum", "the", "paradigm", "of", "C0919437#ent", "<e2>", "and", "subsequently", "in", "the", "relationship", "between", "mismatch", "repair", "colon", "cancer"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0919437", "name": "C0919437#ent", "pos": [16, 17]}}
{"token": ["C0052694#ent", "<e1>", "and", "avarol", "are", "novel", "C0010858#ent", "<e2>", "have", "potent", "antileukemic", "activity", "in", "vitro", "in", "vivo", "mice", ")", "."], "h": {"id": "C0052694", "name": "C0052694#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010858", "name": "C0010858#ent", "pos": [6, 7]}}
{"token": ["In", "children", ",", "there", "are", "several", "C0042373#ent", "<e1>", "responsible", "for", "C0750151#ent", "<e2>", "as", "sickle-cell", "anemia", "acute", "regressive", "angiopathy", "and", "Moya-Moya", "disease", "neurofibromatosis", ",", "dissections", ",", "vasculitis", "associated", "with", "intracranial", "and", "systemic", "infections"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0750151", "name": "C0750151#ent", "pos": [10, 11]}}
{"token": ["Conversely", ",", "bound", "C1537503#ent", "<e1>", "slows", "oxidation-induced", "cross-linking", "between", "C0599220#ent", "<e2>", "of", "the", "RyR1", "tetramer", "."], "h": {"id": "C1537503", "name": "C1537503#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [9, 10]}}
{"token": ["Ponciretin", ",", "C0062585#ent", "<e1>", ",", "naringenin", "and", "diosmetin", "were", "active", "against", "C1415692#ent", "<e2>", "."], "h": {"id": "C0062585", "name": "C0062585#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415692", "name": "C1415692#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "downregulation", "of", "C0376515#ent", "<e1>", "plays", "a", "major", "role", "in", "activation", "of", "caspase-3", "following", "C3149631#ent", "<e2>", "exposure", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3149631", "name": "C3149631#ent", "pos": [17, 18]}}
{"token": ["C1705526#ent", "<e1>", "deletion", "did", "not", "phenocopy", "the", "effects", "of", "C1332412#ent", "<e2>", "deletion", "."], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332412", "name": "C1332412#ent", "pos": [9, 10]}}
{"token": ["In", "unstimulated", "cells", ",", "beta-catenin", "is", "continuously", "targeted", "for", "ubiquitin-dependent", "degradation", "which", "depends", "on", "its", "NH(2)-terminal", "phosphorylation", "by", "glycogen", "synthase", "kinase-3beta", "C4283740#ent", "<e1>", ")", "in", "association", "with", "a", "C0751283#ent", "<e2>"], "h": {"id": "C4283740", "name": "C4283740#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0751283", "name": "C0751283#ent", "pos": [28, 29]}}
{"token": ["In", "venous", "malformations", "the", "expression", "of", "C3811816#ent", "<e1>", "is", "not", "altered", ",", "but", "both", "ephrinB2", "and", "C1705767#ent", "<e2>", "are", "ectopically", "expressed", "in", "venous", "ECs"], "h": {"id": "C3811816", "name": "C3811816#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705767", "name": "C1705767#ent", "pos": [16, 17]}}
{"token": ["C0253596#ent", "<e1>", "ATF3", ")", "is", "rapidly", "induced", "by", "C2697656#ent", "<e2>", "in", "mouse", "macrophages", "regulates", "TLR4", "responses", "."], "h": {"id": "C0253596", "name": "C0253596#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [8, 9]}}
{"token": ["The", "hydrolysis", "of", "ATP", "to", "AMP", "can", "be", "mediated", "either", "by", "the", "concerted", "action", "of", "C3541394#ent", "<e1>", "or", "by", "an", "ATP-diphosphohydrolase", "(", "EC", "3.6.1.5", ";", "C0003652#ent", "<e2>", ")", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0003652", "name": "C0003652#ent", "pos": [25, 26]}}
{"token": ["Incubation", "with", "globular", "C1420276#ent", "<e1>", "inhibited", "autophosphorylation", "of", "C0299856#ent", "<e2>", "PAK4", ")", "compared", "to", "treatment", "with", "monomeric", "alpha-synuclein", "or", "beta-synuclein", "."], "h": {"id": "C1420276", "name": "C1420276#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0299856", "name": "C0299856#ent", "pos": [8, 9]}}
{"token": ["Varying", "protein", "concentrations", "not", "affect", "the", "potencies", "of", "any", "of", "the", "drugs", "against", "C1565860#ent", "<e1>", ",", "with", "the", "exception", "of", "C0301336#ent", "<e2>", "A549", "cells", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0301336", "name": "C0301336#ent", "pos": [20, 21]}}
{"token": ["In", "contrast", ",", "despite", "prolonged", "C0002555#ent", "<e1>", "treatment", "and", "persisting", "hypoestrogenemia", ",", "both", "cortisol", "levels", "adrenal", "responses", "C1704793#ent", "<e2>", "remained", "unaltered", "."], "h": {"id": "C0002555", "name": "C0002555#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704793", "name": "C1704793#ent", "pos": [17, 18]}}
{"token": ["The", "study", "population", "of", "187", "patients", "from", "an", "C0004238#ent", "<e1>", "registry", "with", "paroxysmal", "AF", "were", "orally", "treated", "with", "C0086303#ent", "<e2>", "(", "n", "=", "96", ")", "or", "propafenone", "(", "n", "=", "91", ")", "."], "h": {"id": "C0004238", "name": "C0004238#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0086303", "name": "C0086303#ent", "pos": [18, 19]}}
{"token": ["Additional", "acute", "bronchitis", "pharyngitis", ",", "stomatitis", ",", "C0001361#ent", "<e1>", ",", "conjunctivitis", "and", "C0041976#ent", "<e2>", "indicated", "extensive", "mucosal", "involvement", "."], "h": {"id": "C0001361", "name": "C0001361#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0041976", "name": "C0041976#ent", "pos": [12, 13]}}
{"token": ["We", "describe", "a", "second", "mammalian", "rdgB", "homolog", "m-rdgB2", ")", "that", "possesses", "46", "%", "amino", "acid", "to", "Drosophila", "C1427271#ent", "<e1>", "and", "56", "%", "identity", "to", "C3640149#ent", "<e2>", "."], "h": {"id": "C1427271", "name": "C1427271#ent", "pos": [17, 18]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3640149", "name": "C3640149#ent", "pos": [24, 25]}}
{"token": ["In", "transfected", "cells", ",", "C3539739#ent", "<e1>", "coaligns", "neurofilaments", "and", "microfilaments", ",", "establishing", "this", "as", "a", "C1414120#ent", "<e2>", "intermediate", "filament", "cytoskeletons", "."], "h": {"id": "C3539739", "name": "C3539739#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1414120", "name": "C1414120#ent", "pos": [15, 16]}}
{"token": ["Progesterone", "treatment", "of", "cultured", "cells", "an", "integrated", "single", "copy", "of", "an", "C1710651#ent", "<e1>", "transgene", "leads", "to", "recruitment", "of", "progesterone", "receptor", "PR", ")", ",", "C1337050#ent", "<e2>", ",", "and", "SNF2h-related", "complexes", "to", "C1710651#ent", "<e1>", "promoter", "."], "h": {"id": "C1710651", "name": "C1710651#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1337050", "name": "C1337050#ent", "pos": [23, 24]}}
{"token": ["Other", "proteolytic", "enzymes", "trypsin", ",", "chymotrypsin", ",", "papain", ",", "and", "C0038599#ent", "<e1>", ",", "digested", "the", "C0027096#ent", "<e2>", "in", "the", "same", "way", "as", "skeletal", "myosin"], "h": {"id": "C0038599", "name": "C0038599#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0027096", "name": "C0027096#ent", "pos": [15, 16]}}
{"token": ["C1858559#ent", "<e1>", "is", "highly", "expressed", "in", "skeletal", "muscle", "heart", ",", "ovary", "and", "C0771711#ent", "<e2>", ",", "tissues", "in", "which", "AKT2", "mRNA", "is", "abundant", "."], "h": {"id": "C1858559", "name": "C1858559#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0771711", "name": "C0771711#ent", "pos": [12, 13]}}
{"token": ["Most", "of", "the", "dystrophic", "axonal", "processes", "are", "incorporated", "in", "the", "peripheral", "area", "the", "C4255078#ent", "<e1>", "and", "are", "positive", "for", "phosphorylated", "tau", "[", "C1336986#ent", "<e2>", "]", "and", "tau-5", "."], "h": {"id": "C4255078", "name": "C4255078#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1336986", "name": "C1336986#ent", "pos": [22, 23]}}
{"token": ["The", "isolated", "insert-a", "BamHI", "5.6-kb", "fragment-was", "sequenced", "and", "shown", "to", "contain", "three", "open-reading", "frames", "in", "an", "C0022895#ent", "<e1>", "and", "coding", "for", "proteins", "analogous", "to", "DnaK", ",", "C1426341#ent", "<e2>", "and", "DnaJ", ",", "successively", "."], "h": {"id": "C0022895", "name": "C0022895#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1426341", "name": "C1426341#ent", "pos": [26, 27]}}
{"token": ["Although", "overall", "C0239739#ent", "<e1>", "was", "not", "affected", "by", "C0700583#ent", "<e2>", ",", "individual", "C0239739#ent", "<e1>", "measurements", "were", "reduced", "by", "C0700583#ent", "<e2>", "at", "the", "first", "period", "of", "the", "study", "."], "h": {"id": "C0239739", "name": "C0239739#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0700583", "name": "C0700583#ent", "pos": [8, 9]}}
{"token": ["Functional", "studies", "in", "HEK293", "cells", "that", "C1540185#ent", "<e1>", "mutations", "lead", "to", "reduced", "secretion", "of", "the", "C0298973#ent", "<e2>", "possibly", "owing", "to", "the", "misfolding", "of", "C1540185#ent", "<e1>", "."], "h": {"id": "C0298973", "name": "C0298973#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1540185", "name": "C1540185#ent", "pos": [6, 7]}}
{"token": ["The", "murine", "monoclonal", "antibody", "selectively", "and", "specifically", "inhibits", "the", "activity", "of", "human", "C0206528#ent", "<e1>", "cDNA", "fragments", "encode", "the", "variable", "regions", "of", "the", "light", "and", "C1420192#ent", "<e2>", "isolated", "by", "PCR-mediated", "cloning", "and", "sequenced", "."], "h": {"id": "C0206528", "name": "C0206528#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420192", "name": "C1420192#ent", "pos": [24, 25]}}
{"token": ["Thus", ",", "IL-1", "reduced", "hepatocyte", "growth", "factor", "C0399440#ent", "<e1>", ")", "and", "promoted", "C1366557#ent", "<e2>", "release", ",", "thus", "contributing", "to", "the", "impaired", "liver", "regeneration", "associated", "with", "ROLT", "."], "h": {"id": "C0399440", "name": "C0399440#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1366557", "name": "C1366557#ent", "pos": [12, 13]}}
{"token": ["Using", "human", "COX-1", "and", "human", "and", "murine", "COX-2", ",", "we", "have", "identified", "two", "C3539947#ent", "<e1>", "in", "the", "C0030065#ent", "<e2>", "control", "the", "stereochemistry", "at", "C-15", "."], "h": {"id": "C3539947", "name": "C3539947#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0030065", "name": "C0030065#ent", "pos": [17, 18]}}
{"token": ["An", "ultraviolet", "spectrophotometric", "method", "been", "developed", "for", "indirect", "determination", "of", "aspirin", "(", "C3853627#ent", "<e1>", ")", "using", "the", "difference", "between", "C0073983#ent", "<e2>", "free", "salicylic", "acid", "rabbit", "plasma", "."], "h": {"id": "C3853627", "name": "C3853627#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0073983", "name": "C0073983#ent", "pos": [19, 20]}}
{"token": ["The", "toxicity", "of", "thapsigargin", ",", "a", "selective", "inhibitor", "of", "C0916181#ent", "<e1>", "was", "investigated", "in", "C3537450#ent", "<e2>", "-", "7", "cells", ",", "a", "murine", "hypothalamic", "cell", "line"], "h": {"id": "C0916181", "name": "C0916181#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3537450", "name": "C3537450#ent", "pos": [14, 15]}}
{"token": ["We", "isolated", "AR1", "and", "C1417826#ent", "<e1>", "cDNAs", "using", "a", "mung", "bean", "Phaseolus", "aureus", "L.", ")", "NADPH-Cyt", "C0027310#ent", "<e2>", "cDNA", "as", "a", "probe", "."], "h": {"id": "C1417826", "name": "C1417826#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027310", "name": "C0027310#ent", "pos": [16, 17]}}
{"token": ["Sj\u00f6gren's", "syndrome", "C0085077#ent", "<e1>", ")", "is", "an", "incurable", ",", "C0341305#ent", "<e2>", "predominantly", "affects", "females", "and", "whose", "pathogenesis", "remains", "unknown", "."], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0341305", "name": "C0341305#ent", "pos": [9, 10]}}
{"token": ["Sj\u00f6gren's", "syndrome", "C0085077#ent", "<e1>", ")", "is", "an", "C0341305#ent", "<e2>", "associated", "with", "multiple", "autoantibodies", "lymphocyte", "infiltration", "various", "organs", ",", "and", "functional", "deficiency", "T", "cells"], "h": {"id": "C0085077", "name": "C0085077#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0341305", "name": "C0341305#ent", "pos": [7, 8]}}
{"token": ["We", "show", "that", "GnRH", "treatment", "promotes", "the", "nuclear", "accumulation", "C1332803#ent", "<e1>", ",", "activation", "of", "T", "cell", "factor-dependent", "transcription", "and", "up-regulation", "of", "Wnt", "target", "genes", "C0162508#ent", "<e2>", ",", "Fra-1", ",", "and", "c-Myc", "."], "h": {"id": "C1332803", "name": "C1332803#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162508", "name": "C0162508#ent", "pos": [24, 25]}}
{"token": ["We", "found", "that", "the", "main", "constituent", "of", "aortic", "medial", "amyloid", "is", "a", "50-aa-long", "peptide", ",", "here", "called", "C1334502#ent", "<e1>", ",", "that", "is", "positioned", "within", "the", "C1414508#ent", "<e2>", "lactadherin", "."], "h": {"id": "C1334502", "name": "C1334502#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1414508", "name": "C1414508#ent", "pos": [25, 26]}}
{"token": ["The", "two", "C3541394#ent", "<e1>", "had", "opposite", "substrate", "specificities", ",", "and", "C0014982#ent", "<e2>", "showed", "a", "high", "preference", "to", "plasmalogen", "synthesis", "especially", "in", "the", "presence", "of", "CDP-choline", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014982", "name": "C0014982#ent", "pos": [10, 11]}}
{"token": ["C1384665#ent", "<e1>", ",", "or", "primary", "iron", "overload", "is", "a", "variably", "expressed", "C0025517#ent", "<e2>", "modified", "by", "sex", ",", "age", ",", "diet", ",", "and", "alcohol", "consumption"], "h": {"id": "C1384665", "name": "C1384665#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0025517", "name": "C0025517#ent", "pos": [11, 12]}}
{"token": ["Twenty-seven", "patients", "with", "C0011860#ent", "<e1>", "divided", "into", "C0071097#ent", "<e2>", "(", "Pio", ")", ",", "metformin-treated", "(", "Met", ")", ",", "and", "exercise-treated", "(", "Ex", ")", "groups", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0071097", "name": "C0071097#ent", "pos": [7, 8]}}
{"token": ["Our", "aim", "was", "to", "examine", "the", "role", "of", "NO", "and", "intestinal", "mast", "cells", "investigating", "the", "effects", "of", "NO", "synthase", "NOS", ")", "inhibitors", "and", "a", "C3537042#ent", "<e1>", "induction", "of", "C0079225#ent", "<e2>", "DSS", ")", "colitis", "."], "h": {"id": "C3537042", "name": "C3537042#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0079225", "name": "C0079225#ent", "pos": [28, 29]}}
{"token": ["The", "present", "work", "outlines", "the", "possible", "adverse", "interactions", "the", "three", "main", "calcium", "antagonists", "other", "therapeutic", "agents", "including", "digoxin", ",", "beta", "blockers", "C3537142#ent", "<e1>", ",", "anesthetic", ",", "antihypertensive", ",", "C0282556#ent", "<e2>", ",", "and", "antidiabetic", "drugs", "contrast", "media"], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0282556", "name": "C0282556#ent", "pos": [28, 29]}}
{"token": ["The", "monoamine", "and", "glutamate", "agonists", "induced", "Fos-like", "protein", "in", "striatal", "neurons", "that", "constitutively", "expressed", "the", "C1418823#ent", "<e1>", "DARPP-32", "(", "dopamine", "and", "C0056694#ent", "<e2>", "."], "h": {"id": "C1418823", "name": "C1418823#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0056694", "name": "C0056694#ent", "pos": [21, 22]}}
{"token": ["Bull", "sperm", "treated", "with", "levels", "of", "cholesterol-loaded", "cyclodextrin", "(", "C1538472#ent", "<e1>", ")", "and", "frozen", "in", "egg", "yolk", "diluents", "containing", "either", "C0041175#ent", "<e2>", "or", "sodium", "citrate", "to", "determine", "the", "C1538472#ent", "<e1>", "concentration", "that", "best", "benefits", "bull", "sperm", "."], "h": {"id": "C0041175", "name": "C0041175#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1538472", "name": "C1538472#ent", "pos": [9, 10]}}
{"token": ["C0078442#ent", "<e1>", ",", "ketotifen", "and", "C0771004#ent", "<e2>", "also", "significantly", "inhibited", "the", "BK-induced", "BC", ";", "epinastine", "had", "the", "strongest", "anti-BK", "effect", "among", "them", "."], "h": {"id": "C0078442", "name": "C0078442#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0771004", "name": "C0771004#ent", "pos": [5, 6]}}
{"token": ["Unlike", "dopamine", "antagonists", "C2917322#ent", "<e1>", "inhibited", "apomorphine-induced", "cage", "climbing", "only", "at", "doses", "that", "caused", "C0004134#ent", "<e2>", "."], "h": {"id": "C2917322", "name": "C2917322#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [14, 15]}}
{"token": ["A", "recent", "report", "suggested", "C2983386#ent", "<e1>", "(", "Slit", "and", "Trk-like", "1", "as", "a", "candidate", "gene", "for", "C0040517#ent", "<e2>", "TS", ")", "."], "h": {"id": "C2983386", "name": "C2983386#ent", "pos": [4, 5]}, "relation": "gene_associated_with_disease", "t": {"id": "C0040517", "name": "C0040517#ent", "pos": [16, 17]}}
{"token": ["Gastric", "basal", "secretions", "H+", "and", "HCO3-", "were", "not", "affected", "by", "atropine", "or", "C0062637#ent", "<e1>", ",", "but", "both", "C0035064#ent", "<e2>", "inhibited", "basal", "duodenal", "secretion", "."], "h": {"id": "C0062637", "name": "C0062637#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [17, 18]}}
{"token": ["The", "first", "target", "autoantigen", "to", "have", "been", "identified", "in", "C0271560#ent", "<e1>", "a", "49", "kDa", "protein", ",", "identified", "as", "C2364020#ent", "<e2>", "."], "h": {"id": "C0271560", "name": "C0271560#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2364020", "name": "C2364020#ent", "pos": [18, 19]}}
{"token": ["Southern", "blot", "analysis", "that", "C1414998#ent", "<e1>", "belonged", "to", "a", "C0017363#ent", "<e2>"], "h": {"id": "C1414998", "name": "C1414998#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017363", "name": "C0017363#ent", "pos": [9, 10]}}
{"token": ["This", "is", "a", "first", "reported", "case", "of", "C2711248#ent", "<e1>", "induced", "by", "C1881172#ent", "<e2>", "."], "h": {"id": "C2711248", "name": "C2711248#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1881172", "name": "C1881172#ent", "pos": [11, 12]}}
{"token": ["N-methyl-d-aspartate", "activated", "phosphorylation", "of", "C0752312#ent", "<e1>", "increased", "expression", "level", "of", "C1418464#ent", "<e2>", "and", "Per2", "mRNA", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418464", "name": "C1418464#ent", "pos": [10, 11]}}
{"token": ["Aztreonam", "was", "well", "tolerated", ",", "although", "one", "case", "of", "C0011606#ent", "<e1>", "one", "of", "C0238106#ent", "<e2>", "."], "h": {"id": "C0011606", "name": "C0011606#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0238106", "name": "C0238106#ent", "pos": [13, 14]}}
{"token": ["The", "mean", "cost", "for", "treating", "one", "C0023223#ent", "<e1>", "skin", "grafting", "estimated", "at", "C1704820#ent", "<e2>", "89000", "(", "US$", "11125", ")", "."], "h": {"id": "C0023223", "name": "C0023223#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704820", "name": "C1704820#ent", "pos": [12, 13]}}
{"token": ["The", "possible", "significance", "of", "prepartum", "monocytic", "infiltration", "is", "discussed", "in", "relation", "to", "the", "effect", "of", "changing", "plasma", "and", "C0567085#ent", "<e1>", "concentrations", "of", "progesterone", "on", "C0162745#ent", "<e2>", "activity", "."], "h": {"id": "C0567085", "name": "C0567085#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [24, 25]}}
{"token": ["However", ",", "selective", "PKC", "inhibitor", "C0054537#ent", "<e1>", "100", "nM", ")", "did", "not", "inhibit", "C0669365#ent", "<e2>", "induction", "by", "shear", "stress"], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [13, 14]}}
{"token": ["Fibromuscular", "dysplasia", "C3810599#ent", "<e1>", ")", "is", "a", "rare", "non-atherosclerotic", "and", "C1290884#ent", "<e2>", "the", "arterial", "system"], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [10, 11]}}
{"token": ["A", "sialidase-susceptible", "C0017978#ent", "<e1>", "was", "isolated", "from", "normal", "human", "brain", "by", "C0057214#ent", "<e2>", "Iatrobeads", "column", "chromatography"], "h": {"id": "C0017978", "name": "C0017978#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0057214", "name": "C0057214#ent", "pos": [11, 12]}}
{"token": ["Two", "potent", "new", "ribonucleotide", "reductase", "inhibitors", "C0094454#ent", "<e1>", "C1704963#ent", "<e2>", "122", ")", "and", "3,4-dihydroxybenzohydroxamic", "acid", "C1704963#ent", "<e2>", "147", ")", ",", "were", "investigated", "for", "their", "ability", "to", "modulate", "the", "cellular", "pharmacology", "cytarabine", "(", "ara-C", ")", "in", "HL-60", "cells"], "h": {"id": "C0094454", "name": "C0094454#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704963", "name": "C1704963#ent", "pos": [8, 9]}}
{"token": ["The", "C0286330#ent", "<e1>", "a", "large", "multi-protein", "complex", "that", "functions", "to", "degrade", "C0086376#ent", "<e2>", "tagged", "with", "multi-ubiquitin", "chains", "."], "h": {"id": "C0286330", "name": "C0286330#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0086376", "name": "C0086376#ent", "pos": [11, 12]}}
{"token": ["aex-3", "mutations", "also", "show", "strong", "genetic", "interactions", "mutations", "in", "C1413079#ent", "<e1>", "and", "unc-64", ",", "two", "other", "C0017337#ent", "<e2>", "implicated", "in", "synaptic", "transmission"], "h": {"id": "C1413079", "name": "C1413079#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [16, 17]}}
{"token": ["However", ",", "Dna2p", "has", "a", "role", "in", "a", "pathway", "for", "processing", "structured", "flaps", ",", "in", "which", "it", "aids", "C0252912#ent", "<e1>", "using", "both", "its", "nuclease", "and", "C1333949#ent", "<e2>", "activities", "."], "h": {"id": "C0252912", "name": "C0252912#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [25, 26]}}
{"token": ["It", "is", "assumed", "that", "analgesia", "is", "underutilized", "among", "those", "with", "C0002395#ent", "<e1>", "that", "these", "patients", "may", "be", "inappropriately", "prescribed", "neuroleptics", "and", "C4048284#ent", "<e2>", "."], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C4048284", "name": "C4048284#ent", "pos": [21, 22]}}
{"token": ["The", "subcellular", "mechanism", "and", "site", "of", "action", "of", "linopirdine", "or", "C0058810#ent", "<e1>", "3,3-bis(4-pyridinylmethyl)-1-phenylindolin-2-one", ")", "was", "investigated", "at", "the", "C0751950#ent", "<e2>", "using", "miniature", "endplate", "potential", "m.e.p.p", ".", ")"], "h": {"id": "C0058810", "name": "C0058810#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [18, 19]}}
{"token": ["Sequencing", ",", "denaturing", "HPLC", "restriction", "fragment-length", "polymorphism", "and", "polymerase", "chain", "reaction", "used", "to", "detect", "polymorphisms", "on", "the", "promoters", "and", "complete", "coding", "regions", "NQO1", ",", "C0919426#ent", "<e1>", ",", "MPO", ",", "and", "the", "null", "genotypes", "C0919534#ent", "<e2>", "and", "GSTT1", "."], "h": {"id": "C0919426", "name": "C0919426#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0919534", "name": "C0919534#ent", "pos": [33, 34]}}
{"token": ["C0017337#ent", "<e1>", "of", "the", "C1537474#ent", "<e2>", "MAGE", ")", "family", "are", "characterized", "by", "the", "expression", "of", "tumor", "antigens", "a", "malignant", "melanoma", "by", "autologous", "cytolytic", "T", "lymphocytes"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1537474", "name": "C1537474#ent", "pos": [4, 5]}}
{"token": ["The", "prophylactic", "efficacy", "of", "a", "single", "oral", "dose", "C0146196#ent", "<e1>", "against", "coccidiosis", "(", "C0275524#ent", "<e2>", "in", "naturally", "infected", "lambs", "was", "evaluated", "in", "two", "experiments", "."], "h": {"id": "C0146196", "name": "C0146196#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0275524", "name": "C0275524#ent", "pos": [13, 14]}}
{"token": ["C4021534#ent", "<e1>", "SNHL", ")", "is", "infrequently", "associated", "with", "C0031117#ent", "<e2>"], "h": {"id": "C4021534", "name": "C4021534#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [8, 9]}}
{"token": ["These", "results", "indicate", "that", "C1419142#ent", "<e1>", "induce", "the", "activation", "of", "Cdc42", "through", "C0080298#ent", "<e2>", "and", "FRG", "locally", "at", "the", "nectin-based", "cell-cell", "adhesion", "sites"], "h": {"id": "C1419142", "name": "C1419142#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0080298", "name": "C0080298#ent", "pos": [12, 13]}}
{"token": ["The", "protein", ",", "which", "might", "play", "an", "important", "role", "in", "denitrification", ",", "dissociates", "mainly", "into", "two", "components", "after", "exposure", "to", "air", ":", "a", "C0024708#ent", "<e1>", "GP-MnSOD", ")", "and", "a", "C0028615#ent", "<e2>"], "h": {"id": "C0024708", "name": "C0024708#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0028615", "name": "C0028615#ent", "pos": [29, 30]}}
{"token": ["In", "fact", ",", "contraction", "and", "SAP", "could", "also", "be", "induced", "by", "C0812384#ent", "<e1>", "itself", "at", "3.0", "mmol/L", "concentration", "and", "antagonized", "by", "C0280858#ent", "<e2>", "(", "1", "mumol/L", ")", "within", "10", "min", "."], "h": {"id": "C0812384", "name": "C0812384#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0280858", "name": "C0280858#ent", "pos": [21, 22]}}
{"token": ["PD-123319", "aggravated", "C0268731#ent", "<e1>", "increased", "glomerular", "TGF-beta1", "and", "C3540638#ent", "<e2>", "."], "h": {"id": "C0268731", "name": "C0268731#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540638", "name": "C3540638#ent", "pos": [8, 9]}}
{"token": ["Rheumatoid", "arthritis", "RA", ")", "is", "a", "C3714552#ent", "<e1>", "autoimmune", "disease", "has", "traditionally", "been", "treated", "with", "C0242708#ent", "<e2>", "DMARDs", ")", "."], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242708", "name": "C0242708#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "the", "significant", "increase", "of", "vertebral", "arterial", "blood", "flow", "induced", "by", "C0952164#ent", "<e1>", "due", "to", "the", "peculiarity", "of", "vascular", "myorelaxation", "by", "this", "C1254351#ent", "<e2>", "."], "h": {"id": "C0952164", "name": "C0952164#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [25, 26]}}
{"token": ["In", "addition", ",", "data", "are", "reviewed", "on", "the", "use", "of", "C0962603#ent", "<e1>", "in", "combination", "with", "other", "C0991617#ent", "<e2>", "and", "in", "other", "diseases", ",", "including", "psoriatic", "arthritis"], "h": {"id": "C0962603", "name": "C0962603#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [16, 17]}}
{"token": ["Mutations", "in", "C1417679#ent", "<e1>", "encoding", "the", "gamma2", "subunit", "of", "AMP-activated", "protein", "kinase", "C1418905#ent", "<e2>", ")", ",", "alpha-galactosidase", "A", "GLA", ")", "and", "lysosome-associated", "membrane", "proteine-2", "LAMP2", ")", "can", "cause", "profound", "myocardial", "hypertrophy", "association", "with", "electrophysiological", "defects"], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1418905", "name": "C1418905#ent", "pos": [12, 13]}}
{"token": ["Accumulation", "of", "oxidative", "damage", "in", "neurons", "either", "primarily", "or", "secondarily", "may", "account", "for", "the", "increased", "incidence", "of", "C0795956#ent", "<e1>", "such", "as", "AD", ",", "C1704945#ent", "<e2>", "and", "stroke", "in", "aged", "populations", "."], "h": {"id": "C0795956", "name": "C0795956#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [23, 24]}}
{"token": ["In", "contrast", ",", "C1335822#ent", "<e1>", "interact", "with", "non-phosphorylated", "forms", "of", "C1335875#ent", "<e2>", "."], "h": {"id": "C1335822", "name": "C1335822#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1335875", "name": "C1335875#ent", "pos": [10, 11]}}
{"token": ["Methylprednisolone", "succinate", "unesterified", "hydrocortisone", "produced", "similar", "impairment", "of", "monocyte", "chemotaxis", "two", "drugs", "which", "unmodified", "do", "not", "enter", "cells", ",", "C0056383#ent", "<e1>", "HCP", ")", "and", "C0063077#ent", "<e2>", "had", "no", "effect", "chemotaxis", "."], "h": {"id": "C0056383", "name": "C0056383#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0063077", "name": "C0063077#ent", "pos": [24, 25]}}
{"token": ["C0039496#ent", "<e1>", "a", "multiple", "congenital", "anomaly", "mental", "retardation", "syndrome", "by", "coarse", "face", "C0010495#ent", "<e2>", "cardiomyopathy", "and", "predisposition", "to", "tumors", "."], "h": {"id": "C0039496", "name": "C0039496#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010495", "name": "C0010495#ent", "pos": [12, 13]}}
{"token": ["Localisation", "of", "C1413389#ent", "<e1>", ",", "its", "human", "homolog", "has", "shown", "the", "C0017337#ent", "<e2>", "to", "be", "located", "within", "the", "orthologous", "but", "inverted", "human", "CDX4-XIST", "segment", "."], "h": {"id": "C1413389", "name": "C1413389#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["We", "investigated", "the", "conformation", "of", "C0678133#ent", "<e1>", "and", "the", "interaction", "of", "C0678133#ent", "<e1>", "with", "C0216971#ent", "<e1>", "(", "DPPC", ")", "liposomes", "using", "fluorescence", ",", "circular", "dichroism", "differential", "scanning", "calorimetry", "fluorescence", "polarization", "and", "X-ray", "diffraction"], "h": {"id": "C0678133", "name": "C0678133#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0216971", "name": "C0216971#ent", "pos": [14, 15]}}
{"token": ["Protein", "analysis", "the", "C0017837#ent", "<e1>", "normal", "testicular", "tissue", "the", "presence", "of", "the", "C0769262#ent", "<e2>", "mu", "and", "pi", ",", "with", "a", "predominance", "of", "the", "mu", "class"], "h": {"id": "C0017837", "name": "C0017837#ent", "pos": [3, 4]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0769262", "name": "C0769262#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "supported", "the", "pathogenesis", "that", "immune", "deposits", "tissues", "caused", "C0033680#ent", "<e1>", "PLGE", ")", "in", "C0026272#ent", "<e2>", "."], "h": {"id": "C0033680", "name": "C0033680#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026272", "name": "C0026272#ent", "pos": [15, 16]}}
{"token": ["Non-lytic", "C1424628#ent", "<e1>", "detachment", "was", "determined", "to", "be", "largely", "oxygen", "radical", ",", "because", "PMA-activated", "C0018203#ent", "<e2>", "neutrophils", "and", "PMA-activated", "normal", "neutrophils", "produced", "similar", "disruption", "of", "C1424628#ent", "<e1>", "monolayers", "."], "h": {"id": "C0018203", "name": "C0018203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1424628", "name": "C1424628#ent", "pos": [1, 2]}}
{"token": ["The", "C0752229#ent", "<e1>", "tested", "were", "tamoxifen", "(", "C1823559#ent", "<e2>", "5.10(-7", ")", "M", "and", "5.10(-6", ")", "M", ")", "and", "40H", "C1823559#ent", "<e2>", "(", "5.10(-8", ")", "M", "and", "5.10(-7", ")", "M", ")", "."], "h": {"id": "C0752229", "name": "C0752229#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1823559", "name": "C1823559#ent", "pos": [7, 8]}}
{"token": ["Chronic", "fatigue", "syndrome", "C0015674#ent", "<e1>", ")", "has", "been", "associated", "with", "increased", "C1418938#ent", "<e2>", "(", "PRL", ")", "responses", "to", "the", "serotonin", "(", "5-HT", ")", "releasing", "agent", "fenfluramine", "."], "h": {"id": "C0015674", "name": "C0015674#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418938", "name": "C1418938#ent", "pos": [11, 12]}}
{"token": ["In", "the", "C1258666#ent", "<e1>", "neurons", ",", "GluR2/R3", "and", "C1415289#ent", "<e2>", "may", "represent", "reserve", "intracytoplasmic", "pools", "of", "receptor", "subunits", "transit", "to", "the", "postsynaptic", "sites"], "h": {"id": "C1258666", "name": "C1258666#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1415289", "name": "C1415289#ent", "pos": [8, 9]}}
{"token": ["In", "contrast", ",", "catalytically", "inactive", "mutants", "of", "C1442489#ent", "<e1>", "do", "not", "block", "NIK-mediated", "phosphorylation", "of", "IKKalpha", "in", "these", "C0751283#ent", "<e2>"], "h": {"id": "C1442489", "name": "C1442489#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0751283", "name": "C0751283#ent", "pos": [18, 19]}}
{"token": ["The", "effects", "of", "GABA", "or", "(+/-)-baclofen", "were", "antagonized", "by", "the", "GABAB", "receptor", "homotaurine", "and", "C0049055#ent", "<e1>", "while", "the", "C0242975#ent", "<e2>", "picrotoxin", "had", "no", "effect"], "h": {"id": "C0049055", "name": "C0049055#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0242975", "name": "C0242975#ent", "pos": [18, 19]}}
{"token": ["In", "order", "to", "study", "the", "C0086376#ent", "<e1>", "encoded", "by", "ETV6", "and", "C0919449#ent", "<e2>", ",", "we", "raised", "polyclonal", "antibodies", "against", "a", "recombinant", "peptide", "to", "the", "junctional", "region", "C0919449#ent", "<e2>", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0919449", "name": "C0919449#ent", "pos": [11, 12]}}
{"token": ["Concordance", "studies", "between", "AGE", "and", "CZE", "involving", "dysproteinemias", "including", "C0086438#ent", "<e1>", ",", "polyclonal", "and", "monoclonal", "gammopathies", "acute", "and", "chronic", "inflammation", "C0027720#ent", "<e2>", ",", "hepatodegenerative", "disease", "cirrhosis", ",", "and", "iron", "deficiency", "anemia", "showed", "96", "%", "agreement", "."], "h": {"id": "C0086438", "name": "C0086438#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0027720", "name": "C0027720#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "preliminary", "clinical", "experience", "in", "the", "use", "of", "C0020402#ent", "<e1>", "(", "HU", ")", "for", "the", "treatment", "of", "C0023223#ent", "<e2>", "thalassaemia", "intermedia", "patients", "with", "associated", "endocrine", "complications", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0023223", "name": "C0023223#ent", "pos": [19, 20]}}
{"token": ["Conformation", "changes", "on", "the", "C1567357#ent", "<e1>", "appear", "to", "be", "localised", "to", "small", "regions", "of", "the", "C0001473#ent", "<e2>", "."], "h": {"id": "C1567357", "name": "C1567357#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [15, 16]}}
{"token": ["With", "the", "exception", "of", "the", "C1567357#ent", "<e1>", "aging", "induced", "a", "decrease", "in", "the", "C0001473#ent", "<e2>", "activities", "from", "normoxic", "rats", "."], "h": {"id": "C1567357", "name": "C1567357#ent", "pos": [5, 6]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0001473", "name": "C0001473#ent", "pos": [13, 14]}}
{"token": ["The", "effects", "of", "agents", "reported", "to", "inhibit", "phospholipase", "A2", "activity", "quinacrine", ",", "spermine", "and", "C0021246#ent", "<e1>", ")", ",", "tubocurarine", "and", "C0010976#ent", "<e2>", "were", "examined", "on", "these", "contractures", "."], "h": {"id": "C0021246", "name": "C0021246#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010976", "name": "C0010976#ent", "pos": [20, 21]}}
{"token": ["We", "also", "interviewed", "29", "age-matched", "survivors", "of", "C0221423#ent", "<e1>", "that", "required", "intubation", ",", "narcotics", ",", "C0005064#ent", "<e2>", ",", "and", "admission", "to", "an", "intensive", "care", "unit"], "h": {"id": "C0221423", "name": "C0221423#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [15, 16]}}
{"token": ["Another", "C2936526#ent", "<e1>", "1-phenylbiguanide", ")", "and", "a", "C2936522#ent", "<e2>", "1-(4-bromophenyl-2,5-dimethoxy)-2-aminopropane", "(", "DOB", ")", "]", "had", "no", "significant", "effect", "."], "h": {"id": "C2936526", "name": "C2936526#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2936522", "name": "C2936522#ent", "pos": [7, 8]}}
{"token": ["We", "compared", "the", "effects", "of", "C0019139#ent", "<e1>", "LMWH", ")", ",", "bemiparin", ",", "and", "C0206461#ent", "<e2>", "with", "unfractionated", "heparin", "UFH", ")", "on", "the", "platelet", "subendothelium", "interaction", "under", "flow", "conditions", "."], "h": {"id": "C0019139", "name": "C0019139#ent", "pos": [5, 6]}, "relation": "structural_class_of", "t": {"id": "C0206461", "name": "C0206461#ent", "pos": [13, 14]}}
{"token": ["An", "association", "between", "C0080298#ent", "<e1>", "and", "STAT1", "was", "increased", "by", "IFN-gamma", "and", "C0872913#ent", "<e2>", ",", "indicating", "the", "direct", "phosphorylation", "of", "STAT1", "by", "PKC-dependent", "C0080298#ent", "<e1>", "activation", "."], "h": {"id": "C0080298", "name": "C0080298#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0872913", "name": "C0872913#ent", "pos": [12, 13]}}
{"token": ["The", "three-dimensional", "structure", "C0030137#ent", "<e1>", "(", "PFF", ")", "in", "its", "complex", "with", "the", "C0007075#ent", "<e2>", "CPA", ")", "has", "been", "determined", "at", "2.0", "A", "resolution", "by", "X-ray", "crystallographic", "methods"], "h": {"id": "C0030137", "name": "C0030137#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0007075", "name": "C0007075#ent", "pos": [13, 14]}}
{"token": ["A", "wise", "heterogeneity", "was", "detected", ",", "characterized", "by", "11", "C0005283#ent", "<e1>", ",", "3", "Hb", "variant", "and", "4", "C0544482#ent", "<e2>"], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0544482", "name": "C0544482#ent", "pos": [17, 18]}}
{"token": ["The", "molecular", "cloning", "in", "vitro", "expression", "in", "Escherichia", "coli", "E.", "caproni", "C0031691#ent", "<e1>", "allowed", "us", "to", "determine", "that", "the", "protein", "contains", "431", "C3539947#ent", "<e2>", "a", "theoretical", "MW", "46272", "Da", "."], "h": {"id": "C0031691", "name": "C0031691#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [22, 23]}}
{"token": ["To", "investigate", "the", "effects", "of", "C0025677#ent", "<e1>", "(", "MTX", ")", "and", "platelet", "activating", "factor", "C0235480#ent", "<e2>", ")", "antagonist", "ginkgolide", "B", "BN52021", ")", "on", "C0235480#ent", "<e2>", "induced", "chemotaxis", "of", "neutrophils", "."], "h": {"id": "C0025677", "name": "C0025677#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0235480", "name": "C0235480#ent", "pos": [14, 15]}}
{"token": ["Beta-methyldigoxin", "does", "not", "appear", "to", "be", "a", "satisfactory", "alternative", "to", "other", "effective", "C0991617#ent", "<e1>", "available", "for", "the", "prompt", "correction", "of", "C0030591#ent", "<e2>"], "h": {"id": "C0991617", "name": "C0991617#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0030591", "name": "C0030591#ent", "pos": [20, 21]}}
{"token": ["Quantitative", "polymerase", "chain", "reaction", "PCR", ")", "was", "used", "to", "monitor", "C1422342#ent", "<e1>", "ECaC", ")", "and", "C1420229#ent", "<e2>", "NCX", ")", "mRNA", "levels", "following", "7", "-", "28", "days", "of", "exposure", "to", "treatments", "."], "h": {"id": "C1422342", "name": "C1422342#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1420229", "name": "C1420229#ent", "pos": [15, 16]}}
{"token": ["Upregulation", "of", "C1366449#ent", "<e1>", "expression", "is", "considered", "important", "in", "C0003850#ent", "<e2>", ",", "angiogenesis", "and", "tumor", "metastasis"], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [9, 10]}}
{"token": ["Their", "function", "is", "mediated", "by", "the", "C1414332#ent", "<e1>", "AGOs", ")", ",", "which", "colocalize", "to", "P-bodies", "with", "mRNA", "degradation", "C3541394#ent", "<e2>", "."], "h": {"id": "C1414332", "name": "C1414332#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [18, 19]}}
{"token": ["These", "results", "indicate", "that", "C3272782#ent", "<e1>", "derived", "from", "C0003873#ent", "<e2>", "synovial", "tissue", "a", "role", "in", "promoting", "B", "cell", "by", "inducing", "Bcl-xL", "expression", "and", "blocking", "B", "cell", "apoptosis", "in", "a", "CD49d/CD29-CD106-dependent", "manner", "."], "h": {"id": "C3272782", "name": "C3272782#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [8, 9]}}
{"token": ["For", "this", "purpose", "we", "studied", "C1366370#ent", "<e1>", "and", "FVIIag", "in", "relation", "to", "C0542037#ent", "<e2>", "after", "a", "standardized", "test", "meal", "."], "h": {"id": "C1366370", "name": "C1366370#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0542037", "name": "C0542037#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "stimulation", "of", "C4084713#ent", "<e1>", "leads", "to", "the", "accumulation", "of", "GTP-bound", "C0084340#ent", "<e2>", "in", "the", "cytoplasm", "."], "h": {"id": "C4084713", "name": "C4084713#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0084340", "name": "C0084340#ent", "pos": [13, 14]}}
{"token": ["The", "role", "of", "cathepsins", "D", "potent", "inflammatory", "agents", "for", "the", "generation", "of", "biologically", "active", "peptides", "--", "C0127400#ent", "<e1>", "of", "inflammation", "from", "the", "protein", "substrates", "including", "C0086509#ent", "<e2>", "under", "desintegration", "of", "lysosomes", "is", "discussed", "."], "h": {"id": "C0127400", "name": "C0127400#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0086509", "name": "C0086509#ent", "pos": [25, 26]}}
{"token": ["To", "investigate", "the", "genomic", "imbalances", "and", "identify", "the", "C0280950#ent", "<e1>", "associated", "with", "tumor", ",", "we", "applied", "comparative", "genomic", "hybridization", "C1415796#ent", "<e2>", ")", "in", "OC", "cell", "lines"], "h": {"id": "C0280950", "name": "C0280950#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415796", "name": "C1415796#ent", "pos": [19, 20]}}
{"token": ["Because", "the", "pathology", "of", "diseases", "such", "as", "C0042900#ent", "<e1>", ",", "alopecia", "and", "C0023646#ent", "<e2>", "thought", "to", "involve", "immune", "mechanisms", "the", "beneficial", "effect", "of", "PUVA", "may", "be", "due", "to", "immunosuppression", "."], "h": {"id": "C0042900", "name": "C0042900#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023646", "name": "C0023646#ent", "pos": [12, 13]}}
{"token": ["This", "effect", "was", "specific", "for", "transforming", "C0079972#ent", "<e1>", "and", "was", "not", "seen", "after", "overexpression", "of", "the", "C3853563#ent", "<e2>", "v-mos", "."], "h": {"id": "C0079972", "name": "C0079972#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3853563", "name": "C3853563#ent", "pos": [16, 17]}}
{"token": ["C0001126#ent", "<e1>", "RTA", ")", "can", "lead", "to", "rickets", "in", "children", "or", "C3887650#ent", "<e2>", "in", "adults", "if", "undetected", "."], "h": {"id": "C0001126", "name": "C0001126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887650", "name": "C3887650#ent", "pos": [11, 12]}}
{"token": ["C1538931#ent", "<e1>", ",", "like", "JM4", ",", "is", "a", "C0021699#ent", "<e2>", "which", "binds", "to", "the", "CCR5", "receptor"], "h": {"id": "C1538931", "name": "C1538931#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [8, 9]}}
{"token": ["To", "date", ",", "C0234133#ent", "<e1>", "involuntary", "movements", "been", "rarely", "reported", "in", "C0752120#ent", "<e2>", "."], "h": {"id": "C0234133", "name": "C0234133#ent", "pos": [3, 4]}, "relation": "manifestation_of", "t": {"id": "C0752120", "name": "C0752120#ent", "pos": [11, 12]}}
{"token": ["It", "was", "concluded", "that", "the", "novel", "25", "K", "and", "80/27", "K", "proteins", "endogenous", "components", "of", "the", "human", "C1418610#ent", "<e1>", "than", "fragments", "or", "aggregates", "of", "the", "known", "C1420598#ent", "<e2>"], "h": {"id": "C1418610", "name": "C1418610#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420598", "name": "C1420598#ent", "pos": [26, 27]}}
{"token": ["Microcystins", "(", "C1822783#ent", "<e1>", ")", "are", "a", "group", "of", "closely", "related", "C0030957#ent", "<e2>", "by", "a", "variety", "of", "common", "cyanobacteria", "."], "h": {"id": "C1822783", "name": "C1822783#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0030957", "name": "C0030957#ent", "pos": [11, 12]}}
{"token": ["Among", "104", "men", "who", "had", "organic", "disorders", "erection", "half", "due", "to", "C0030846#ent", "<e1>", "the", "remainder", "to", "vascular", "disease", "C0011875#ent", "<e2>", "arteriosclerosis", ",", "abnormal", "venous", "drainage", "."], "h": {"id": "C0030846", "name": "C0030846#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0011875", "name": "C0011875#ent", "pos": [18, 19]}}
{"token": ["Previous", "studies", "showed", "that", "barren", "inflorescence2", "(", "C1334867#ent", "<e1>", ")", "encodes", "a", "C1413288#ent", "<e2>", "regulates", "auxin", "transport", "and", "barren", "stalk1", "(", "ba1", ")", "encodes", "a", "basic", "helix-loop-helix", "transcription", "factor", "acts", "downstream", "of", "auxin", "transport"], "h": {"id": "C1334867", "name": "C1334867#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413288", "name": "C1413288#ent", "pos": [12, 13]}}
{"token": ["Bacterial", "pneumonia", "the", "most", "common", "cause", "of", "death", "from", "C1535939#ent", "<e1>", "in", "patients", "with", "C0343755#ent", "<e2>", "causing", "greater", "mortality", "than", "Pneumocystis", "carinii", "C1535939#ent", "<e1>", "."], "h": {"id": "C0343755", "name": "C0343755#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1535939", "name": "C1535939#ent", "pos": [9, 10]}}
{"token": ["Hearts", "transplanted", "into", "C1420709#ent", "<e1>", "recipients", "showed", "decreased", "CD4(+", ")", "lymphocyte", "infiltration", "and", "diminished", "C1337091#ent", "<e2>", "as", "judged", "by", "CD25", "expression", "."], "h": {"id": "C1420709", "name": "C1420709#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1337091", "name": "C1337091#ent", "pos": [14, 15]}}
{"token": ["Down-regulation", "of", "EGf", "receptor", "activated", "C1705572#ent", "<e1>", "and", "the", "possible", "involvement", "of", "a", "transcription", "factor", "C0812312#ent", "<e2>", "will", "be", "discussed", "."], "h": {"id": "C1705572", "name": "C1705572#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [15, 16]}}
{"token": ["This", "nucleotide", "change", "a", "C1704466#ent", "<e1>", "codon", "to", "a", "C0003486#ent", "<e2>", "(", "stop", ")", "codon", "at", "amino", "acid", "Gln195", "in", "the", "runt", "domain", "CBFA1", "."], "h": {"id": "C1704466", "name": "C1704466#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0003486", "name": "C0003486#ent", "pos": [9, 10]}}
{"token": ["Because", "of", "the", "C0003451#ent", "<e1>", "CD8+", "cells", "we", "examined", "the", "potential", "anti-HIV", "activity", "C1333877#ent", "<e2>", "can", "be", "found", "in", "CD8", "+", "cell", "culture", "fluids", "."], "h": {"id": "C0003451", "name": "C0003451#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333877", "name": "C1333877#ent", "pos": [13, 14]}}
{"token": ["Restriction", "enzyme", "shows", "that", "the", "C1257646#ent", "<e1>", "lies", "within", "2.2", "kb", "of", "the", "C1333471#ent", "<e2>"], "h": {"id": "C1257646", "name": "C1257646#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333471", "name": "C1333471#ent", "pos": [13, 14]}}
{"token": ["Knockdown", "of", "Rab8A", "and", "Rab14", ",", "but", "not", "of", "C1428953#ent", "<e1>", "or", "Rab10", ",", "inhibited", "insulin-induced", "C2982484#ent", "<e2>", "translocation", "."], "h": {"id": "C1428953", "name": "C1428953#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [16, 17]}}
{"token": ["C0026654#ent", "<e1>", "(", "MM", ")", "disease", "is", "a", "rare", "C0948441#ent", "<e2>", "to", "occur", "in", "children", "and", "adults", "."], "h": {"id": "C0026654", "name": "C0026654#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0948441", "name": "C0948441#ent", "pos": [9, 10]}}
{"token": ["This", "molecular", "mechanism", "the", "inhibition", "of", "CAD", "DNase", "C0010068#ent", "<e1>", "is", "similar", "to", "that", "proposed", "for", "C0014230#ent", "<e2>", "its", "inhibitor", ",", "immunity", "protein"], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0014230", "name": "C0014230#ent", "pos": [16, 17]}}
{"token": ["We", "examined", "the", "efficacy", "of", "C0385385#ent", "<e1>", "in", "a", "C0079224#ent", "<e2>", "colitis", "model"], "h": {"id": "C0385385", "name": "C0385385#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0079224", "name": "C0079224#ent", "pos": [9, 10]}}
{"token": ["All", "C1535939#ent", "<e1>", "animals", "tested", "in", "adulthood", "(", "C1417807#ent", "<e2>", "53", "-", "93", ")", "showed", "deficits", "in", "cognitive", "flexibility", "specifically", "in", "their", "ability", "to", "shift", "attentional", "set", "compared", "to", "controls", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417807", "name": "C1417807#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "we", "compared", "the", "stimulation", "of", "C0032143#ent", "<e1>", "activity", "by", "PrP(c", ")", "and", "C0078939#ent", "<e2>", "1", "-", "42", ")", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0078939", "name": "C0078939#ent", "pos": [14, 15]}}
{"token": ["Since", "the", "discovery", "of", "the", "FMR1", "gene", "for", "the", "C0039082#ent", "<e1>", ",", "molecular", ",", "rather", "than", "cytogenetic", ",", "diagnosis", "of", "C0016667#ent", "<e2>", "become", "the", "gold", "standard"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0016667", "name": "C0016667#ent", "pos": [20, 21]}}
{"token": ["These", "data", "indicate", "that", "C1704816#ent", "<e1>", "expression", "can", "be", "regulated", "by", "C1706038#ent", "<e2>", "and", "serves", "to", "mediate", "the", "control", "of", "C1706038#ent", "<e2>", "of", "the", "proliferation", "and", "migration", "of", "IEC-6", "cells", "."], "h": {"id": "C1704816", "name": "C1704816#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1706038", "name": "C1706038#ent", "pos": [11, 12]}}
{"token": ["C0242430#ent", "<e1>", "effectively", "reduces", "radial", "artery", "RA", ")", "C0026821#ent", "<e2>", "in", "vitro", "but", "clinical", "data", "its", "use", "during", "coronary", "revascularization", "lacking", "."], "h": {"id": "C0242430", "name": "C0242430#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026821", "name": "C0026821#ent", "pos": [8, 9]}}
{"token": ["The", "dephosphorylation", "of", "phosphorylase", "by", "protein", "phosphatase-1", "suppressed", "by", "basic", "C1305923#ent", "<e1>", ",", "protamine", "and", "C0032518#ent", "<e2>", "being", "the", "most", "potent", "inhibitors", "."], "h": {"id": "C1305923", "name": "C1305923#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0032518", "name": "C0032518#ent", "pos": [15, 16]}}
{"token": ["C0055729#ent", "<e1>", ",", "a", "novel", "C0032177#ent", "<e2>", "inhibits", "intimal", "proliferation", "animal", "models"], "h": {"id": "C0055729", "name": "C0055729#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032177", "name": "C0032177#ent", "pos": [5, 6]}}
{"token": ["In", "contrast", ",", "our", "data", "do", "not", "support", "an", "association", "between", "C0524620#ent", "<e1>", "hypertension", "in", "pregnant", "women", "C1412446#ent", "<e2>", "and", "chronic", "hypertension"], "h": {"id": "C0524620", "name": "C0524620#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1412446", "name": "C1412446#ent", "pos": [17, 18]}}
{"token": ["The", "synthetic", "rate", "lipase", ",", "ribonclease", ",", "proelastase", ",", "another", "chymotrypsinogen", "and", "of", "two", "C0960371#ent", "<e1>", "was", "unaffected", "when", "feeding", "RSD", "is", "compared", "to", "feeding", "C1837657#ent", "<e2>", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1837657", "name": "C1837657#ent", "pos": [25, 26]}}
{"token": ["C1413917#ent", "<e1>", "consists", "of", "4", "alpha-helixes", ",", "covering", "the", "sequence", "from", "C0815040#ent", "<e2>", "11", ",", "20", "-", "38", ",", "51", "-", "62", "and", "72", "-", "85", ",", "respectively", "."], "h": {"id": "C1413917", "name": "C1413917#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0815040", "name": "C0815040#ent", "pos": [11, 12]}}
{"token": ["The", "combined", "effect", "of", "thyroid", "hormone", "receptor", "retinoid", "X", "receptors", "T3-stimulated", "SERCA2", "C0812327#ent", "<e1>", "also", "markedly", "attenuated", "by", "C0178469#ent", "<e2>", "stimulation", "."], "h": {"id": "C0812327", "name": "C0812327#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0178469", "name": "C0178469#ent", "pos": [18, 19]}}
{"token": ["The", "ED(50", ")", "values", "of", "C0062021#ent", "<e1>", "suppression", "of", "the", "C3543842#ent", "<e2>", "and", "clonic", "phases", "of", "sound-induced", "seizures", "were", "3.6", "and", "4.3", "mg/kg", ",", "respectively", "."], "h": {"id": "C0062021", "name": "C0062021#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [10, 11]}}
{"token": ["Drugs", "blocking", "C1708300#ent", "<e1>", "5-HT2C", "receptors", "be", "preferred", "over", "those", "whose", "C0020592#ent", "<e2>", "caused", "by", "histamine", "receptor", "blockade", "only", "."], "h": {"id": "C1708300", "name": "C1708300#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020592", "name": "C0020592#ent", "pos": [11, 12]}}
{"token": ["A", "56-year-old", "Japanese", "female", "simultaneously", "developed", "thrombocytopenia", ",", "C0074494#ent", "<e1>", "symptoms", ",", "and", "an", "elevation", "of", "C0002594#ent", "<e2>", "."], "h": {"id": "C0074494", "name": "C0074494#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002594", "name": "C0002594#ent", "pos": [16, 17]}}
{"token": ["There", "were", "no", "seroconversion", "or", "C0002594#ent", "<e1>", "changes", "in", "comparison", "with", "values", "before", "C0443121#ent", "<e2>", "."], "h": {"id": "C0002594", "name": "C0002594#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0443121", "name": "C0443121#ent", "pos": [13, 14]}}
{"token": ["Binding", "sites", "the", "consensus", "were", "also", "obtained", "for", "Pbx1", "complexed", "with", "C1366503#ent", "<e1>", ",", "which", "lacks", "a", "C0633070#ent", "<e2>", "but", "requires", "a", "conserved", "tryptophan-containing", "motif", "for", "cooperativity", "with", "Pbx", "."], "h": {"id": "C1366503", "name": "C1366503#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0633070", "name": "C0633070#ent", "pos": [17, 18]}}
{"token": ["Nine", "premature", "infants", "with", "C3898352#ent", "<e1>", "C0006287#ent", "<e2>", ")", "have", "undergone", "fundoplication", "for", "FTT", ",", "worsening", "C0006287#ent", "<e2>", ",", "and", "pneumonia", "."], "h": {"id": "C3898352", "name": "C3898352#ent", "pos": [4, 5]}, "relation": "has_nichd_parent", "t": {"id": "C0006287", "name": "C0006287#ent", "pos": [6, 7]}}
{"token": ["Patients", "with", "neurofibromatosis", "type", "1", "NF1", ")", "can", "manifest", "a", "C0042373#ent", "<e1>", "in", "adults", "is", "rarely", "associated", "with", "fatal", "C0151814#ent", "<e2>"], "h": {"id": "C0042373", "name": "C0042373#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0151814", "name": "C0151814#ent", "pos": [19, 20]}}
{"token": ["C0960865#ent", "<e1>", "is", "the", "master", "regulator", "activates", "the", "virulence", "determinant", "C0017337#ent", "<e2>", "of", "Shigella", "spp"], "h": {"id": "C0960865", "name": "C0960865#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "C1883559#ent", "<e1>", "co-immunoprecipitates", "with", "a", "prominent", "component", "of", "the", "multiprotein", "replication", "complex", "C1366837#ent", "<e2>", "PCNA", ")", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [14, 15]}}
{"token": ["Furthermore", ",", "C1883559#ent", "<e1>", "co-immunoprecipitates", "with", "a", "prominent", "component", "of", "the", "multiprotein", "replication", "complex", "proliferating", "cell", "nuclear", "antigen", "C1366837#ent", "<e2>", ")", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1366837", "name": "C1366837#ent", "pos": [18, 19]}}
{"token": ["Differentiation", "of", "Ml", "cells", "induced", "by", "C0011777#ent", "<e1>", "was", "markedly", "inhibited", "by", "C0256103#ent", "<e2>", "and", "high", "mol", "."], "h": {"id": "C0011777", "name": "C0011777#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0256103", "name": "C0256103#ent", "pos": [12, 13]}}
{"token": ["Phase", "I", "studies", "shown", "that", "dose-limiting", "toxicities", "C1135132#ent", "<e1>", "are", "generally", "neurotoxicity", "and", "C0023530#ent", "<e2>", "although", "initial", "studies", "with", "patupilone", "indicated", "that", "diarrhoea", "was", "dose", "limiting", "."], "h": {"id": "C1135132", "name": "C1135132#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023530", "name": "C0023530#ent", "pos": [13, 14]}}
{"token": ["After", "long-term", "CCl(4", ")", "treatment", ",", "C0239946#ent", "<e1>", "strongly", "aggravated", "in", "the", "C1417701#ent", "<e2>", "knockout", "mice", "inflammation", "was", "enhanced", "."], "h": {"id": "C0239946", "name": "C0239946#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1417701", "name": "C1417701#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "sulfalene", "(", "1500", "mg", ")", "+", "C0034283#ent", "<e1>", "(", "75", "mg", ")", "has", "no", "advantage", "over", "the", "C1412999#ent", "<e2>", "(", "1000", "+", "50", ")", "mg", "."], "h": {"id": "C0034283", "name": "C0034283#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [19, 20]}}
{"token": ["The", "clinical", "and", "pathological", "features", "of", "acute", "non-infectious", "arthritis", "the", "C1709823#ent", "<e1>", "appear", "to", "delineate", "a", "distinct", "C1848862#ent", "<e2>", "."], "h": {"id": "C1709823", "name": "C1709823#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [17, 18]}}
{"token": ["4", "C0699440#ent", "<e1>", "administered", "in", "single", "doses", "patients", "with", "stable", ",", "treated", "C0018802#ent", "<e2>", "impaired", "blood", "pressure", "during", "exercise", "."], "h": {"id": "C0699440", "name": "C0699440#ent", "pos": [1, 2]}, "relation": "may_treat", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [12, 13]}}
{"token": ["This", "study", "showed", "that", "PRL", "stimulated", "the", "phosphorylation", "of", "C1307407#ent", "<e1>", ",", "p70S6K", "Akt", ",", "and", "C0169661#ent", "<e2>", "a", "dose-", "and", "time-dependent", "manner", "in", "PRL-dependent", "rat", "Nb2", "lymphoma", "cells"], "h": {"id": "C1307407", "name": "C1307407#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0169661", "name": "C0169661#ent", "pos": [16, 17]}}
{"token": ["Whole", "animal", "C1705610#ent", "<e1>", "was", "significantly", "greater", "in", "P", "than", "in", "C1824810#ent", "<e2>", "animals", "(", "42.7", "+", "/-", "1.7", "versus", "31.9", "+", "/-", "1.8", "mumol.min-1", ",", "respectively", ",", "p", "<", "0.001", ")", "."], "h": {"id": "C1705610", "name": "C1705610#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1824810", "name": "C1824810#ent", "pos": [11, 12]}}
{"token": ["Rats", "pretreated", "with", "the", "nonspecific", "catecholamine", "depletors", "reserpine", "or", "C0018318#ent", "<e1>", "had", "a", "significantly", "less", "severe", "C0041976#ent", "<e2>", "vehicle-treated", "controls", "."], "h": {"id": "C0018318", "name": "C0018318#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0041976", "name": "C0041976#ent", "pos": [16, 17]}}
{"token": ["Here", "we", "have", "hypothesized", "that", "pinealectomy", "may", "increase", "hippocampal", "vulnerability", "by", "eliminating", "the", "C3543842#ent", "<e1>", "inhibitory", "action", "of", "melatonin", "on", "C2348848#ent", "<e2>", "."], "h": {"id": "C3543842", "name": "C3543842#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2348848", "name": "C2348848#ent", "pos": [20, 21]}}
{"token": ["The", "present", "study", "reports", "cerebral", "blood", "flow", "C1428360#ent", "<e1>", ")", "measurements", "in", "11", "patients", "during", "attacks", "of", "classic", "C0149931#ent", "<e2>", "(CM)--migraine", "with", "aura", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [18, 19]}}
{"token": ["Secondary", "structure", "between", "control", "Mb", "and", "Mb", "incubated", "with", "C3538705#ent", "<e1>", "were", "not", "detected", "by", "C1705969#ent", "<e2>", "."], "h": {"id": "C3538705", "name": "C3538705#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705969", "name": "C1705969#ent", "pos": [15, 16]}}
{"token": ["Metformin", ",", "a", "C0005382#ent", "<e1>", "antidiabetic", "agent", "was", "shown", "to", "affect", "insulin", "resistance", "decreasing", "enzymatic", "activity", "overexpressed", "C1418599#ent", "<e2>", "obese", "type", "2", "diabetics"], "h": {"id": "C0005382", "name": "C0005382#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418599", "name": "C1418599#ent", "pos": [17, 18]}}
{"token": ["Nineteen", "patients", "with", "C0409326#ent", "<e1>", "the", "classical", "features", "of", "C0034931#ent", "<e2>", "RSD", ")", "were", "investigated", "by", "local", "anesthetic", "sympathetic", "blockade"], "h": {"id": "C0409326", "name": "C0409326#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034931", "name": "C0034931#ent", "pos": [9, 10]}}
{"token": ["We", "describe", "two", "cases", "of", "C0206062#ent", "<e1>", "patients", "with", "non-Hodgkin's", "lymphoma", "were", "treated", "with", "combination", "chemotherapy", "C0026259#ent", "<e2>", "."], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026259", "name": "C0026259#ent", "pos": [16, 17]}}
{"token": ["Seven", "patients", "with", "C0026946#ent", "<e1>", "the", "bones", "and", "joints", "were", "treated", "with", "C0022625#ent", "<e2>", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0022625", "name": "C0022625#ent", "pos": [12, 13]}}
{"token": ["Fragmentation", "of", "the", "neuronal", "Golgi", "apparatus", "GA", ")", "was", "reported", "in", "C1862939#ent", "<e1>", "ALS", ")", ",", "corticobasal", "degeneration", "Alzheimer's", "Creutzfeldt-Jacob", "disease", "and", "in", "C0752121#ent", "<e2>", "SCA2", ")", "."], "h": {"id": "C1862939", "name": "C1862939#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0752121", "name": "C0752121#ent", "pos": [23, 24]}}
{"token": ["The", "methods", "used", "are", "C1418676#ent", "<e1>", ",", "CCSD", ",", "CCSD(T", ")", "and", "C2931461#ent", "<e2>", "with", "6", "-", "311G(d", ")", ",", "cc-pVTZ", "and", "aug-cc-pVTZ", "basis", "sets", "."], "h": {"id": "C1418676", "name": "C1418676#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2931461", "name": "C2931461#ent", "pos": [12, 13]}}
{"token": ["In", "batch", "cultures", "valine", "dehydrogenase", "VDH", ";", "EC", "1.4.1.8", ")", ",", "threonine", "dehydratase", "C3887634#ent", "<e1>", ";", "EC", "4.2.1.16", ")", "and", "aspartate", "aminotransferase", "ASAT", ";", "C0684153#ent", "<e2>", "reached", "their", "highest", "specific", "activities", "at", "120", "h."], "h": {"id": "C3887634", "name": "C3887634#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0684153", "name": "C0684153#ent", "pos": [24, 25]}}
{"token": ["Based", "on", "clinical", "features", ",", "infantile", "seborrheic", "dermatitis", "C0375381#ent", "<e1>", ")", "can", "be", "classified", "as", "follows", ":", "C0036508#ent", "<e2>", "SD", ")", ",", "psoriasiform", "seborrheic", "dermatitis", "Psor", "SD", ")", ",", "and", "erythrodermic", "seborrheic", "dermatitis"], "h": {"id": "C0375381", "name": "C0375381#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036508", "name": "C0036508#ent", "pos": [17, 18]}}
{"token": ["As", "for", "C0021847#ent", "<e1>", ",", "the", "frequency", "of", "symptomatic", "C0021847#ent", "<e1>", "was", "higher", "in", "patients", "with", "inactive", "ALDH2", "and", "usual", "C1705836#ent", "<e1>", "."], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705836", "name": "C1705836#ent", "pos": [20, 21]}}
{"token": ["Patients", "who", "received", "nimesulide", "showed", "improvement", "in", "the", "signs", "and", "symptoms", "evaluated", ":", "pharyngeal", "redness", "tonsillar", "redness", "tonsillar", "swelling", "hoarseness", ",", "C0723402#ent", "<e1>", "headache", ",", "and", "C0019559#ent", "<e2>", "."], "h": {"id": "C0723402", "name": "C0723402#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0019559", "name": "C0019559#ent", "pos": [26, 27]}}
{"token": ["The", "plasma", "concentrations", "of", "glutathione", "and", "C0061516#ent", "<e1>", "measured", "in", "rats", "following", "the", "administration", "of", "diquat", ",", "C0025872#ent", "<e2>", ",", "nitrofurantoin", ",", "doxorubicin", ",", "dimethylnitrosamine", "or", "carbon", "tetrachloride"], "h": {"id": "C0061516", "name": "C0061516#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0025872", "name": "C0025872#ent", "pos": [17, 18]}}
{"token": ["The", "domestic", "ferret", "Mustela", "putorius", "furo", "is", "an", "ideal", "animal", "model", "influenza", "infections", "potentially", "other", "human", "C0035204#ent", "<e1>", "as", "cystic", "fibrosis", "where", "mouse", "models", "failed", "to", "reproduce", "the", "C0012634#ent", "<e2>", "phenotype", "."], "h": {"id": "C0035204", "name": "C0035204#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [28, 29]}}
{"token": ["Inhibition", "of", "the", "C0257151#ent", "<e1>", "similar", "results", ",", "whereas", "C0297666#ent", "<e2>", "had", "no", "effect", "LPS-reduced", "apoptosis", "."], "h": {"id": "C0257151", "name": "C0257151#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0297666", "name": "C0297666#ent", "pos": [9, 10]}}
{"token": ["Recent", "studies", "have", "demonstrated", "cleavage", "of", "C0085114#ent", "<e1>", "by", "calpain", ",", "a", "calcium-dependent", "C1667078#ent", "<e2>", "and", "marked", "activation", "of", "the", "calpain", "system", "in", "the", "degradation", "of", "C0085114#ent", "<e1>", "in", "these", "tumors", "."], "h": {"id": "C0085114", "name": "C0085114#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1667078", "name": "C1667078#ent", "pos": [13, 14]}}
{"token": ["25", "skin", "biopsy", "isolates", "of", "Borrelia", "burgdorferi", "sensu", "lato", "mainly", "from", "German", "patients", "with", "erythema", "migrans", "C1705457#ent", "<e1>", "]", ",", "borrelial", "lymphocytoma", "BL", "]", "and", "C0263421#ent", "<e2>", "ACA", "]", ",", "were", "species-differentiated", "using", "pulsed-field", "gel", "electrophoresis", "PFGE", ")", "."], "h": {"id": "C1705457", "name": "C1705457#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0263421", "name": "C0263421#ent", "pos": [25, 26]}}
{"token": ["A", "decrease", "in", "the", "levels", "of", "serum", "total", "protein", "C1412332#ent", "<e1>", ",", "serum", "total", ",", "free", "and", "C0008385#ent", "<e2>", "observed", "in", "vivax", "malaria", "."], "h": {"id": "C1412332", "name": "C1412332#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [17, 18]}}
{"token": ["A", "C0040709#ent", "<e1>", "S.", "cerevisiae", "strain", "accumulated", "D-xylulose", "5-phosphate", "intracellularly", "and", "released", "ribitol", "and", "C0242209#ent", "<e2>", "D-ribose", ",", "D-ribulose", ",", "and", "D-xylulose", ")", "into", "the", "growth", "medium"], "h": {"id": "C0040709", "name": "C0040709#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242209", "name": "C0242209#ent", "pos": [14, 15]}}
{"token": ["The", "risk", "factors", "postoperative", "C0015967#ent", "<e1>", "were", "the", "patient's", "age", ",", "diabetes", "mellitus", "obesity", ",", "preoperative", "C0238990#ent", "<e2>", "smoking", ",", "duration", "of", "surgery", "operator", "'s", "surgical", "experience", "and", "urethral", "catheterisation"], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0238990", "name": "C0238990#ent", "pos": [16, 17]}}
{"token": ["C1881502#ent", "<e1>", "cDNA", "suppressed", "the", "mutator", "phenotype", "of", "E.coli", "mutY.", "In", "vitro", "expressed", "C1881502#ent", "<e1>", "showed", "adenine", "DNA", "glycosylase", "toward", "the", "A", ":", "C1822658#ent", "<e1>", "substrate", "."], "h": {"id": "C1881502", "name": "C1881502#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1822658", "name": "C1822658#ent", "pos": [23, 24]}}
{"token": ["C0009262#ent", "<e1>", ",", "a", "microtubule", "inhibitor", "disorganized", "the", "tubulin-", "and", "C0054521#ent", "<e2>", "fluorescent", "structure", "of", "mitotic", "3Y1", "cells", "."], "h": {"id": "C0009262", "name": "C0009262#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0054521", "name": "C0054521#ent", "pos": [10, 11]}}
{"token": ["Incubation", "with", "[1-(14)C]C6-ceramide", "showed", "that", "cells", "converted", "short-chain", "ceramide", "into", "C1367452#ent", "<e1>", ",", "lactosylceramide", ",", "and", "C0037903#ent", "<e2>", "."], "h": {"id": "C1367452", "name": "C1367452#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037903", "name": "C0037903#ent", "pos": [16, 17]}}
{"token": ["C1418441#ent", "<e1>", "PDHK2", ")", "is", "a", "unique", "C0914594#ent", "<e2>", "regulates", "the", "activity", "of", "the", "pyruvate", "dehydrogenase", "multienzyme", "complex", "PDC", ")", "."], "h": {"id": "C1418441", "name": "C1418441#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0914594", "name": "C0914594#ent", "pos": [7, 8]}}
{"token": ["The", "primary", "purpose", "of", "this", "study", "was", "to", "compare", "the", "efficacy", "and", "tolerability", "of", "C0732569#ent", "<e1>", "versus", "ranitidine", "in", "the", "treatment", "of", "patients", "with", "C0013295#ent", "<e2>"], "h": {"id": "C0732569", "name": "C0732569#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0013295", "name": "C0013295#ent", "pos": [24, 25]}}
{"token": ["At", "the", "protein", "level", "the", "expressions", "of", "C1823242#ent", "<e1>", ",", "BCRP", "and", "C1539696#ent", "<e2>", "but", "MRP1", "in", "HepG2/ADM", "were", "significantly", "higher", "than", "those", "of", "HepG2", "and", "L02", "."], "h": {"id": "C1823242", "name": "C1823242#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1539696", "name": "C1539696#ent", "pos": [12, 13]}}
{"token": ["Among", "the", "medications", "used", "in", "metabolic", "syndrome", "therapy", "also", "C3540783#ent", "<e1>", "and", "statins", "for", "atherogenic", "dyslipidemia", "those", "lowering", "blood", "pressure", "such", "as", "angiotensin-converting", "enzyme", "inhibitors", "C0815017#ent", "<e2>"], "h": {"id": "C3540783", "name": "C3540783#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0815017", "name": "C0815017#ent", "pos": [25, 26]}}
{"token": ["C0267782#ent", "<e1>", "a", "rare", "cause", "of", "acute", "abdominal", "pain", "and", "clinically", "mimics", "C0003615#ent", "<e2>"], "h": {"id": "C0267782", "name": "C0267782#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003615", "name": "C0003615#ent", "pos": [12, 13]}}
{"token": ["This", "structure", ",", "which", "only", "contains", "the", "C0086648#ent", "<e1>", "isoform", "of", "C1417739#ent", "<e2>", ",", "also", "contains", "beta-catenin", "and", "N-cadherin", ",", "consistent", "with", "role", "in", "cell", "adhesion"], "h": {"id": "C0086648", "name": "C0086648#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1417739", "name": "C1417739#ent", "pos": [11, 12]}}
{"token": ["As", "the", "only", "exceptions", ",", "the", "two", "S.cerevisiae", "GAPs", ",", "Ira1p", "and", "Ira2p", ",", "are", "strictly", "specific", "for", "C0242853#ent", "<e1>", "can", "not", "stimulate", "the", "C1333729#ent", "<e2>", "of", "mammalian", "Ras", "."], "h": {"id": "C0242853", "name": "C0242853#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1333729", "name": "C1333729#ent", "pos": [24, 25]}}
{"token": ["These", "data", "indicate", "that", "altered", "dopaminergic", "neurotransmission", "not", "be", "important", "for", "the", "anti-anxiety", "effect", "C0006462#ent", "<e1>", "and", "that", "C0006462#ent", "<e1>", "should", "be", "tested", "for", "efficacy", "in", "various", "models", "of", "C0026650#ent", "<e1>"], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0026650", "name": "C0026650#ent", "pos": [29, 30]}}
{"token": ["C0035064#ent", "<e1>", "for", "NLA", "with", "C0059306#ent", "<e2>", "are", "preferable", "for", "general", "anesthesia", "patients", "undergoing", "operations", "on", "the", "hepatopancreatoduodenal", "zone", "."], "h": {"id": "C0035064", "name": "C0035064#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0059306", "name": "C0059306#ent", "pos": [5, 6]}}
{"token": ["To", "confirm", "the", "identity", "of", "the", "C1415877#ent", "<e1>", "examine", "the", "relationship", "between", "IDH1", "and", "C2714104#ent", "<e2>", ",", "the", "C1415877#ent", "<e1>", "disrupted", "by", "genomic", "replacement", "a", "haploid", "yeast", "strain", "."], "h": {"id": "C1415877", "name": "C1415877#ent", "pos": [6, 7]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2714104", "name": "C2714104#ent", "pos": [14, 15]}}
{"token": ["Kin28", "and", "C3540050#ent", "<e1>", "also", "have", "overlapping", "roles", "in", "promoting", "C0101555#ent", "<e2>", "dissociation", "of", "the", "preinitiation", "complex", "PIC", ")", "into", "the", "Scaffold", "complex"], "h": {"id": "C3540050", "name": "C3540050#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [10, 11]}}
{"token": ["In", "this", "study", ",", "the", "effects", "of", "colchicine", "on", "C0033681#ent", "<e1>", "phosphorylation", "induced", "by", "C1412759#ent", "<e2>", "and", "CPPD", "crystals", "in", "human", "blood", "neutrophils", "investigated", "."], "h": {"id": "C0033681", "name": "C0033681#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1412759", "name": "C1412759#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "both", "C0030306#ent", "<e1>", "and", "cysteine", "proteinases", "which", "are", "increased", "in", "patients", "with", "C3899281#ent", "<e2>", "are", "involved", "in", "cartilage", "degradation", "in", "these", "arthropathies", "."], "h": {"id": "C0030306", "name": "C0030306#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3899281", "name": "C3899281#ent", "pos": [16, 17]}}
{"token": ["Caspase-3", "activity", "and", "C1539477#ent", "<e1>", "ligand", "mRNA", "expression", "were", "determined", "in", "hepatocytes", ",", "C1855648#ent", "<e2>", ",", "and", "SECs", "."], "h": {"id": "C1539477", "name": "C1539477#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1855648", "name": "C1855648#ent", "pos": [13, 14]}}
{"token": ["We", "compared", "the", "outcome", "of", "patients", "with", "recurrent", "C0340293#ent", "<e1>", "hospitalized", "in", "coronary", "care", "units", "the", "prereperfusion", "and", "reperfusion", "C1415714#ent", "<e2>", "."], "h": {"id": "C0340293", "name": "C0340293#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1415714", "name": "C1415714#ent", "pos": [19, 20]}}
{"token": ["Coronary", "flow", "measurements", ",", "using", "radiolabeled", "microspheres", ",", "demonstrated", "a", "significant", "(", "p", "<", "0.01", ")", "C0020538#ent", "<e1>", "and", "age-related", "decline", "maximal", "C0596385#ent", "<e2>", "capacity", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0596385", "name": "C0596385#ent", "pos": [22, 23]}}
{"token": ["The", "products", "of", "the", "human", "Arg", "gene", "human", ",", "mouse", ",", "Drosophila", ",", "and", "nematode", "C0080279#ent", "<e1>", "the", "Abelson", "family", "of", "C1336653#ent", "<e2>"], "h": {"id": "C0080279", "name": "C0080279#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1336653", "name": "C1336653#ent", "pos": [21, 22]}}
{"token": ["Transformation", "requires", "C3274826#ent", "<e1>", "C1706044#ent", "<e2>", "and", "the", "C1706044#ent", "<e2>", "binding", "protein", "Gab2", ",", "and", "is", "associated", "with", "hyperactivation", "of", "the", "Erk", ",", "Akt", ",", "and", "Stat5", "pathways"], "h": {"id": "C3274826", "name": "C3274826#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706044", "name": "C1706044#ent", "pos": [4, 5]}}
{"token": ["Co-immunoprecipitation", "studies", "demonstrated", "that", "TRPC1", ",", "but", "not", "TRPC4", ",", "interacts", "with", "C1418640#ent", "<e1>", "and", "the", "inositol", "1,4,5-trisphosphate", "receptor", "C1334148#ent", "<e2>", ")", "."], "h": {"id": "C1418640", "name": "C1418640#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1334148", "name": "C1334148#ent", "pos": [19, 20]}}
{"token": ["We", "describe", "the", "different", "effects", "of", "C0057671#ent", "<e1>", "and", "DADS", "on", "hepatic", "CYP2B1/2", ",", "CYP3A", "and", "C1134446#ent", "<e2>", "EpH", ")", "mRNAs", "in", "rats", ",", "in", "terms", "of", "activation", "profile", "doses", "and", "kinetics", "."], "h": {"id": "C0057671", "name": "C0057671#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1134446", "name": "C1134446#ent", "pos": [16, 17]}}
{"token": ["TPA", "treatment", "leads", "to", "the", "rapid", "activation", "of", "extracellular", "signal-regulated", "kinase", "C1370600#ent", "<e1>", ")", "and", "c-Jun", "NH2-terminal", "kinase", "JNK", ")", ",", "the", "inactivation", "of", "C1456378#ent", "<e2>", "MAPK", ")", ",", "and", "the", "downregulation", "of", "PKCdelta", "."], "h": {"id": "C1370600", "name": "C1370600#ent", "pos": [11, 12]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1456378", "name": "C1456378#ent", "pos": [24, 25]}}
{"token": ["Morphine-induced", "analgesia", "has", "been", "shown", "to", "be", "antagonized", "by", "ginseng", "total", "saponins", "(", "C3891714#ent", "<e1>", ")", ",", "which", "also", "inhibit", "the", "development", "of", "C0728960#ent", "<e2>", "and", "physical", "dependence", "morphine", "."], "h": {"id": "C3891714", "name": "C3891714#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [23, 24]}}
{"token": ["A", "number", "of", "mammalian", "MKPs", "have", "been", "identified", "so", "far", ",", "but", "their", "specific", "physiological", "functions", "negative", "regulation", "of", "C0169101#ent", "<e1>", "not", "been", "C1516876#ent", "<e2>", "defined", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [23, 24]}}
{"token": ["Furthermore", ",", "administration", "of", "oral", "adsorbent", "Kremezin", ")", "significantly", "attenuated", "the", "increase", "in", "C1417708#ent", "<e1>", "concomitantly", "reduced", "interstitial", "inflammation", "renal", "fibrosis", "C0022661#ent", "<e2>", "rats", "."], "h": {"id": "C1417708", "name": "C1417708#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0022661", "name": "C0022661#ent", "pos": [21, 22]}}
{"token": ["C0004259#ent", "<e1>", "(", "1", "mM", ")", "or", "C0034308#ent", "<e2>", "(", "0.5", "mM", ")", "had", "no", "short-term", "effects", "on", "amino", "acid", "uptake", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0034308", "name": "C0034308#ent", "pos": [7, 8]}}
{"token": ["Particularly", "high", "clustering", "activity", "found", "in", "patients", "with", "SLE", "with", "C0017658#ent", "<e1>", "in", "certain", "patients", "with", "C0348165#ent", "<e2>"], "h": {"id": "C0017658", "name": "C0017658#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0348165", "name": "C0348165#ent", "pos": [16, 17]}}
{"token": ["Finally", ",", "TPA", "treatment", "dramatically", "increases", "the", "number", "of", "transformation", "foci", "induced", "in", "C3811118#ent", "<e1>", "Cl", "3", "cells", "retroviruses", "carrying", "v-Ki-ras", ",", "v-Ha-ras", ",", "and", "C0069518#ent", "<e2>"], "h": {"id": "C3811118", "name": "C3811118#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0069518", "name": "C0069518#ent", "pos": [25, 26]}}
{"token": ["The", "aim", "of", "the", "study", "was", "to", "measure", "the", "impact", "of", "Schistosoma", "japonicum", "C0040954#ent", "<e1>", "young", "growing", "pigs", "C0342895#ent", "<e2>", "low-", "or", "high-protein", "diets", "."], "h": {"id": "C0040954", "name": "C0040954#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0342895", "name": "C0342895#ent", "pos": [18, 19]}}
{"token": ["monoglycerides", "(", "MG", ")", ",", "diglycerides", "(", "DG", ")", ",", "and", "triglycerides", "(", "C0039902#ent", "<e1>", ")", ",", "were", "studied", "in", "liver", ",", "plasma", ",", "C0018050#ent", "<e2>", ",", "and", "muscle", "."], "h": {"id": "C0039902", "name": "C0039902#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0018050", "name": "C0018050#ent", "pos": [24, 25]}}
{"token": ["Recent", "in", "vitro", "have", "implicated", "C0010763#ent", "<e1>", "and", "CYP2F2", "in", "the", "bioactivation", "of", "DCE", "to", "2-S-glutathionyl", "C0000979#ent", "<e2>", "[", "C", "]", ",", "a", "putative", "conjugate", "of", "DCE", "epoxide", "with", "glutathione", "."], "h": {"id": "C0010763", "name": "C0010763#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0000979", "name": "C0000979#ent", "pos": [16, 17]}}
{"token": ["The", "synthesis", "and", "analytical", "properties", "two", "asymmetric", "derivatives", "of", "carbohydrazide", "and", "C0076449#ent", "<e1>", "with", "pyridine", "and", "C0031428#ent", "<e2>", "have", "been", "studied", "."], "h": {"id": "C0076449", "name": "C0076449#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0031428", "name": "C0031428#ent", "pos": [16, 17]}}
{"token": ["An", "in", "vivo", "model", "of", "bacterial", "C0024118#ent", "<e1>", "an", "accelerated", "progression", "of", "disease", "in", "C3884157#ent", "<e2>", "(", "but", "not", "SPHK1", ")", "knockout", "mice", "compared", "to", "wild-type", "controls", "."], "h": {"id": "C0024118", "name": "C0024118#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3884157", "name": "C3884157#ent", "pos": [14, 15]}}
{"token": ["Whereas", "C1420543#ent", "<e1>", "associated", "with", "C1420554#ent", "<e2>", "and", "protein", "65", "immunoprecipitated", "vesicle", "populations", ",", "C1420554#ent", "<e2>", "appears", "to", "be", "only", "a", "minor", "constituent", "of", "vesicles", "precipitated", "with", "anti-protein", "65"], "h": {"id": "C1420543", "name": "C1420543#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420554", "name": "C1420554#ent", "pos": [5, 6]}}
{"token": ["Mean", "C3272370#ent", "<e1>", "was", "14", "-", "19", "%", "higher", "in", "the", "C0003364#ent", "<e2>", "compared", "with", "the", "normotensives", "and", "values", "of", "C3272370#ent", "<e1>", "correlated", "significantly", "to", "values", "of", "mean", "BP"], "h": {"id": "C3272370", "name": "C3272370#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003364", "name": "C0003364#ent", "pos": [11, 12]}}
{"token": ["We", "show", "that", "the", "SH3", "domain", "C1420744#ent", "<e1>", "binds", "a", "C0072402#ent", "<e2>", "phosphorylates", "a", "region", "immediately", "C-terminal", "to", "SH3", "domain"], "h": {"id": "C1420744", "name": "C1420744#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0072402", "name": "C0072402#ent", "pos": [10, 11]}}
{"token": ["Tissue-type", "plasminogen", "activator", "tPA", ")", "is", "secreted", "by", "rat", "granulosa", "cells", "response", "to", "treatment", "with", "activators", "of", "protein", "kinase", "A", "follitropin", ",", "FSH", ")", ",", "protein", "kinase", "C", "C1415169#ent", "<e1>", "GnRH", ")", "and", "tyrosine", "kinase", "C1367721#ent", "<e2>", "EGF", ")", "."], "h": {"id": "C1415169", "name": "C1415169#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C1367721", "name": "C1367721#ent", "pos": [35, 36]}}
{"token": ["One", "hundred", "C0015967#ent", "<e1>", "children", "with", "C0026837#ent", "<e2>", "were", "studied", "and", "compared", "to", "334", "C0015967#ent", "<e1>", "matched", "controls", "without", "C0026837#ent", "<e2>", "."], "h": {"id": "C0026837", "name": "C0026837#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015967", "name": "C0015967#ent", "pos": [2, 3]}}
{"token": ["It", "is", "well", "known", "that", "allergen-specific", "nasal", "challenge", "ASNC", ")", "is", "a", "fruitful", "tool", "with", "which", "to", "evaluate", "C0282555#ent", "<e1>", "by", "a", "C1254351#ent", "<e2>", "."], "h": {"id": "C0282555", "name": "C0282555#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [22, 23]}}
{"token": ["C0024002#ent", "<e1>", "was", "compared", "with", "diazepam", "for", "the", "treatment", "of", "C0038220#ent", "<e2>", "a", "double-blind", ",", "randomized", "trial"], "h": {"id": "C0024002", "name": "C0024002#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0038220", "name": "C0038220#ent", "pos": [10, 11]}}
{"token": ["F1", "is", "the", "C0081888#ent", "<e1>", "its", "activity", "is", "inhibited", "by", "calmodulin", "antagonists", "W-7", ",", "C1419423#ent", "<e2>", ",", "tamoxifen", ")", "via", "a", "mechanism", "typical", "for", "the", "majority", "of", "Ca(2+)-calmodulin-dependent", "enzymes", "."], "h": {"id": "C0081888", "name": "C0081888#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1419423", "name": "C1419423#ent", "pos": [14, 15]}}
{"token": ["The", "MMP", "inhibitor", "TIMP-1", ",", "was", "expressed", "in", "both", "stromal", "and", "C1136365#ent", "<e1>", "most", "tumors", ",", "and", "neither", "C0164371#ent", "<e2>", "nor", "neutrophil", "collagenase", "detected", "in", "any", "of", "the", "tumors", "."], "h": {"id": "C1136365", "name": "C1136365#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0164371", "name": "C0164371#ent", "pos": [18, 19]}}
{"token": ["Thus", "about", "10", "times", "higher", "doses", "of", "C2698196#ent", "<e1>", "were", "required", "than", "of", "C0666497#ent", "<e2>", "to", "cause", "a", "similar", "cholesterol-lowering", "effect"], "h": {"id": "C2698196", "name": "C2698196#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0666497", "name": "C0666497#ent", "pos": [13, 14]}}
{"token": ["PROBE", "DRUGS", ":", "Debrisoquine", ",", "C0037760#ent", "<e1>", ",", "metoprolol", "or", "dextromethorphan", "represent", "well-established", "probe", "drugs", "C2350083#ent", "<e2>", "has", "been", "recently", "investigated", "for", "this", "purpose", "."], "h": {"id": "C0037760", "name": "C0037760#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2350083", "name": "C2350083#ent", "pos": [15, 16]}}
{"token": ["IgG", "and", "IgA", "antibodies", "milk", "and", "egg", "proteins", "a", "specificity", "similar", "to", "that", "of", "C1412276#ent", "<e1>", ",", "although", "some", "IgA", "antibodies", "than", "C1412276#ent", "<e1>", "were", "found", "in", "disease", "controls", "C0010346#ent", "<e1>", "ulcerative", "colitis", "post-enteritis", "syndrome", ")", "."], "h": {"id": "C1412276", "name": "C1412276#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0010346", "name": "C0010346#ent", "pos": [29, 30]}}
{"token": ["Risk", "factors", "formation", "of", "stones", "include", "urinary", "promoters", "(", "calcium", ",", "urate", ",", "cystine", ",", "and", "sodium", ")", "and", "C0280038#ent", "<e1>", "magnesium", ",", "citrate", ",", "and", "C0027709#ent", "<e2>", ")", "."], "h": {"id": "C0280038", "name": "C0280038#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0027709", "name": "C0027709#ent", "pos": [26, 27]}}
{"token": ["Systemic", "administration", "anti-NGF", "neutralizing", "antibodies", "the", "behavioral", "sensitivity", ",", "the", "up-regulation", "of", "neuropeptides", "and", "the", "inflammation-induced", "expression", "the", "immediate", "early", "C1706383#ent", "<e1>", "dorsal", "horn", "neurons", ",", "without", "modifying", "swelling", "and", "C0041834#ent", "<e2>", "."], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0041834", "name": "C0041834#ent", "pos": [30, 31]}}
{"token": ["C0040374#ent", "<e1>", "did", "not", "affect", "C1415533#ent", "<e2>", "(", "fasting", "or", "during", "the", "glucose", "infusion", "."], "h": {"id": "C0040374", "name": "C0040374#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415533", "name": "C1415533#ent", "pos": [5, 6]}}
{"token": ["The", "efficacy", "of", "C3255829#ent", "<e1>", "theophylline", "is", "examined", "in", "patients", "with", "stabilized", "C0004096#ent", "<e2>"], "h": {"id": "C3255829", "name": "C3255829#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [12, 13]}}
{"token": ["A", "case", "in", "which", "there", "was", "a", "mixed", "sensorimotor", "C0235025#ent", "<e1>", "neurotropic", "ulceration", "in", "a", "patient", "with", "C1290138#ent", "<e2>", "reported", "."], "h": {"id": "C0235025", "name": "C0235025#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1290138", "name": "C1290138#ent", "pos": [17, 18]}}
{"token": ["C1516876#ent", "<e1>", "determined", "polymorphisms", "of", "N-acetylation", "and", "oxidative", "capacity", "been", "studied", "using", "C0010980#ent", "<e2>", "and", "metoprolol", "in", "51", "Japanese", "patients", "with", "spontaneous", "bladder", "cancer", "203", "healthy", "control", "."], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [12, 13]}}
{"token": ["Pretreatment", "of", "C1332814#ent", "<e1>", "mice", "with", "C0008994#ent", "<e2>", "but", "not", "control", "liposomes", "completely", "prevented", "CRP-mediated", "protection", "."], "h": {"id": "C1332814", "name": "C1332814#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0008994", "name": "C0008994#ent", "pos": [6, 7]}}
{"token": ["The", "decrease", "of", "C1418997#ent", "<e1>", "between", "biological", "stage", "effluent", "and", "the", "increase", "of", "C1832588#ent", "<e2>", "within", "the", "same", "time", "correlate", "well", "."], "h": {"id": "C1418997", "name": "C1418997#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1832588", "name": "C1832588#ent", "pos": [13, 14]}}
{"token": ["In", "this", "study", ",", "the", "interaction", "of", "EAR-2", ",", "C1417833#ent", "<e1>", ",", "and", "RARgamma", "with", "C0879262#ent", "<e2>", "was", "confirmed", "by", "DNA", "mobility", "shift", "analysis", "."], "h": {"id": "C1417833", "name": "C1417833#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0879262", "name": "C0879262#ent", "pos": [15, 16]}}
{"token": ["Although", "small", "C2699123#ent", "<e1>", "expressed", "not", "Oatps", "and", "C1416664#ent", "<e2>", "but", "Mrp3", ",", "rising/piled-up", "C2699123#ent", "<e1>", "expressed", "Oatp1", "and", "2", "and", "Mrp2", "proteins", "the", "sinusoidal", "and", "BC", "membranes", ",", "respectively", "."], "h": {"id": "C2699123", "name": "C2699123#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1416664", "name": "C1416664#ent", "pos": [8, 9]}}
{"token": ["This", "is", "the", "first", "demonstration", "that", "galectin-8", "binds", "to", "specific", "sulfated", "or", "C0017978#ent", "<e1>", "high", "affinity", "(", "C1839259#ent", "<e2>", "approximately", "10", "-", "8", "-", "10", "-", "9", "M", ")", "."], "h": {"id": "C0017978", "name": "C0017978#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [17, 18]}}
{"token": ["C0020498#ent", "<e1>", "confirmed", "that", "SSX", "expression", "originated", "in", "C1416867#ent", "<e2>", "all", "5", "RT-PCR-positive", "tumor", "samples"], "h": {"id": "C0020498", "name": "C0020498#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1416867", "name": "C1416867#ent", "pos": [8, 9]}}
{"token": ["Taken", "together", ",", "these", "findings", "outline", "a", "novel", "signal", "transduction", "pathway", "links", "C3539645#ent", "<e1>", "stimulation", "with", "cyclic", "nucleotide-independent", "activation", "of", "C4084713#ent", "<e2>", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4084713", "name": "C4084713#ent", "pos": [20, 21]}}
{"token": ["C1307220#ent", "<e1>", "was", "found", "C3889446#ent", "<e2>", "in", "30", "%", "of", "the", "endometrial", "carcinoma", "samples", "."], "h": {"id": "C1307220", "name": "C1307220#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889446", "name": "C3889446#ent", "pos": [4, 5]}}
{"token": ["The", "aim", "of", "our", "study", "is", "to", "evaluate", "the", "increase", "of", "bone", "mineral", "density", "BMD", ")", "in", "C0521170#ent", "<e1>", "and", "hyperthyroid", "patients", "treated", "with", "C0279175#ent", "<e2>", "patients", "treated", "with", "C0279175#ent", "<e2>", "diphosphonates", "."], "h": {"id": "C0521170", "name": "C0521170#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0279175", "name": "C0279175#ent", "pos": [24, 25]}}
{"token": ["To", "our", "knowledge", ",", "this", "is", "the", "first", "report", "on", "C1535939#ent", "<e1>", "administration", "of", "C0210657#ent", "<e2>", "containing", "regimen", "."], "h": {"id": "C1535939", "name": "C1535939#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0210657", "name": "C0210657#ent", "pos": [14, 15]}}
{"token": ["The", "results", "with", "C.", "albicans", "amorolfine", "and", "C0076110#ent", "<e1>", "accord", "with", "their", "known", "in", "vivo", "efficacy", "in", "C0026946#ent", "<e2>", "involving", "low-temperature", "superficial", "sites", "and", "poor", "activity", "C0026946#ent", "<e2>", "involving", "deep", "body", "sites"], "h": {"id": "C0076110", "name": "C0076110#ent", "pos": [7, 8]}, "relation": "may_prevent", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [17, 18]}}
{"token": ["The", "dihydroxyacetone", "pathway", "an", "alternative", "pathway", "the", "dissimilation", "of", "glycerol", "via", "reduction", "by", "C0061557#ent", "<e1>", "subsequent", "phosphorylation", "by", "dihydroxyacetone", "(", "C1415467#ent", "<e2>", ")", "kinase", ",", "is", "activated", "in", "the", "yeasts", "Saccharomyces", "cerevisiae", "Zygosaccharomyces", "rouxii", "osmotic", "stress"], "h": {"id": "C0061557", "name": "C0061557#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415467", "name": "C1415467#ent", "pos": [20, 21]}}
{"token": ["Blood", "coagulation", "factor", "IXa", "fIXa", ")", "is", "a", "C0758336#ent", "<e1>", "low", "inherent", "activity", "that", "is", "greatly", "enhanced", "in", "the", "C0015520#ent", "<e2>"], "h": {"id": "C0758336", "name": "C0758336#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0015520", "name": "C0015520#ent", "pos": [19, 20]}}
{"token": ["C0079225#ent", "<e1>", "aggregates", "several", "C0014378#ent", "<e2>", "depending", "not", "only", "on", "the", "pH", ",", "the", "ionic", "strength", "the", "medium", ",", "but", "also", "on", "the", "protein", "content", "the", "fluids", "and", "on", "strain", "specificities", "the", "viruses", "."], "h": {"id": "C0079225", "name": "C0079225#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0014378", "name": "C0014378#ent", "pos": [4, 5]}}
{"token": ["Low", "levels", "of", "neuropeptide", "Y", "somatostatin", "and", "C1366488#ent", "<e1>", "described", "in", "C0002395#ent", "<e2>", "AD", ")", ",", "were", "related", "to", "a", "defect", "in", "proteolytic", "processing", "their", "protein", "precursors"], "h": {"id": "C1366488", "name": "C1366488#ent", "pos": [7, 8]}, "relation": "gene_associated_with_disease", "t": {"id": "C0002395", "name": "C0002395#ent", "pos": [11, 12]}}
{"token": ["From", "the", "isotope", "ratios", "the", "total", "protein", "of", "the", "C0848332#ent", "<e1>", "containing", "the", "synthetase", "chains", "the", "chemical", "amount", "each", "C0023689#ent", "<e2>", "relative", "to", "that", "of", "the", "reference", "culture", "determined", "."], "h": {"id": "C0848332", "name": "C0848332#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023689", "name": "C0023689#ent", "pos": [19, 20]}}
{"token": ["Our", "findings", "suggest", "that", "children", "with", "C0005283#ent", "<e1>", "major", "have", "mild", "restrictive", "C0034049#ent", "<e2>"], "h": {"id": "C0005283", "name": "C0005283#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034049", "name": "C0034049#ent", "pos": [12, 13]}}
{"token": ["The", "ganglion", "blocking", "agents", ",", "C0008211#ent", "<e1>", ",", "pentamethonium", ",", "mecamylamine", ",", "C0057231#ent", "<e2>", "and", "hexamethonium", "all", "block", "nicotine", "extensor", "convulsions", "when", "administered", "intraventricularly", "in", "mice", "."], "h": {"id": "C0008211", "name": "C0008211#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0057231", "name": "C0057231#ent", "pos": [12, 13]}}
{"token": ["High", "extracellular", "Ca2", "+", "concentration", ",", "which", "activated", "C0031651#ent", "<e1>", "in", "hearts", "from", "lean", "animals", "C0917783#ent", "<e2>", "in", "all", "hearts", ",", "failed", "to", "activate", "C0031651#ent", "<e1>", "in", "hearts", "from", "obese", "rats", "."], "h": {"id": "C0031651", "name": "C0031651#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0917783", "name": "C0917783#ent", "pos": [15, 16]}}
{"token": ["The", "predicted", "zebrafish", "C1706514#ent", "<e1>", "hormone", "is", "also", "shorter", ",", "being", "only", "31", "C3539947#ent", "<e2>", "length", "."], "h": {"id": "C1706514", "name": "C1706514#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [13, 14]}}
{"token": ["We", "show", "that", "expression", "of", "C1420667#ent", "<e1>", "is", "directly", "repressed", "by", "C1417840#ent", "<e2>", "during", "differentiation", "of", "the", "human", "teratocarcinoma", "cell", "line", "NT2", "."], "h": {"id": "C1420667", "name": "C1420667#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417840", "name": "C1417840#ent", "pos": [11, 12]}}
{"token": ["Training", "attenuated", "the", "exercise-induced", "drop", "malonyl-CoA", "and", "prevented", "the", "C0004099#ent", "<e1>", "increase", "in", "the", "constant", "for", "citrate", "activation", "of", "C0001022#ent", "<e2>", "the", "red", "quadriceps", "muscle", "rats", "run", "for", "20", "and", "60", "min", "."], "h": {"id": "C0004099", "name": "C0004099#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001022", "name": "C0001022#ent", "pos": [19, 20]}}
{"token": ["It", "is", "concluded", "that", "intravenous", "administration", "C0012381#ent", "<e1>", "has", "no", "advantage", "over", "C0728960#ent", "<e2>", "administered", "by", "other", "routes", "and", "has", "a", "limited", "use", "in", "current", "obstetrical", "practice"], "h": {"id": "C0012381", "name": "C0012381#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0728960", "name": "C0728960#ent", "pos": [12, 13]}}
{"token": ["We", "postulate", "that", "C3714636#ent", "<e1>", "a", "major", "determinant", "of", "the", "severity", "of", "C1418873#ent", "<e2>", "in", "AIDS", ",", "and", "that", "this", "inflammation", "may", "be", "diminished", "by", "high-dose", "corticosteroid", "therapy"], "h": {"id": "C3714636", "name": "C3714636#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418873", "name": "C1418873#ent", "pos": [12, 13]}}
{"token": ["Stability", "of", "the", "derivatives", "in", "sample", "for", "long-term", "storage", "was", "ensured", "by", "C0033993#ent", "<e1>", "excess", "derivatizing", "reagent", ",", "C4283946#ent", "<e2>", ",", "with", "a", "spike", "of", "water", "followed", "by", "dehydration", "using", "anhydrous", "sodium", "sulfate"], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C4283946", "name": "C4283946#ent", "pos": [18, 19]}}
{"token": ["The", "overexpression", "of", "the", "C1412071#ent", "<e1>", "which", "is", "the", "C1334043#ent", "<e2>", "of", "human", "mdr1", "gene", "in", "hepatocellular", "carcinomas", "be", "responsible", "for", "the", "poor", "response", "these", "tumors", "to", "cancer", "chemotherapeutic", "agents"], "h": {"id": "C1412071", "name": "C1412071#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["C1313437#ent", "<e1>", "hereafter", "named", "CPS", ")", "catalyzes", "the", "formation", "of", "the", "C0597979#ent", "<e2>", "the", "biosynthetic", "pathway", "(5R)-carbapen-2-em-3-carboxylate", ",", "the", "simplest", "of", "the", "carbapenem", "antibiotics", "."], "h": {"id": "C1313437", "name": "C1313437#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0597979", "name": "C0597979#ent", "pos": [11, 12]}}
{"token": ["Greater", "than", "40", "mol", "32P", "is", "incorporated", "into", "MAP-2", "by", "C3810565#ent", "<e1>", "compared", "to", "only", "14", "mol", "32P", "observed", "when", "C1956039#ent", "<e2>", "A-kinase", ")", "is", "the", "catalyst", "."], "h": {"id": "C3810565", "name": "C3810565#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1956039", "name": "C1956039#ent", "pos": [20, 21]}}
{"token": ["We", "verified", "that", "C0163159#ent", "<e1>", "significantly", "augmented", "expression", "of", "the", "phase", "II", "enzyme", "genes", "C1738886#ent", "<e2>", "and", "NQO1", "and", "confirmed", "that", "C0163159#ent", "<e1>", "treatment", "increased", "glutathione", "S-transferase", "activity", "epithelial", "cells", "inducing", "cell", "death", "apoptosis", "."], "h": {"id": "C1738886", "name": "C1738886#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0163159", "name": "C0163159#ent", "pos": [3, 4]}}
{"token": ["The", "C1418302#ent", "<e1>", "and", "MCG10as", "proteins", "contain", "two", "domains", "C1334043#ent", "<e2>", "to", "the", "heterogeneous", "nuclear", "ribonucleoprotein", "K", "homology", "KH", ")", "domain", "."], "h": {"id": "C1418302", "name": "C1418302#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [9, 10]}}
{"token": ["In", "experimental", "C0206586#ent", "<e1>", "the", "expression", "of", "C4283800#ent", "<e2>", "significantly", "decreased", ",", "whereas", "there", "were", "no", "obvious", "changes", "in", "the", "expression", "of", "ZO-1", "."], "h": {"id": "C0206586", "name": "C0206586#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C4283800", "name": "C4283800#ent", "pos": [7, 8]}}
{"token": ["C0795959#ent", "<e1>", "is", "a", "rare", "neurocutaneous", "syndrome", "craniosynostosis", ",", "C0004134#ent", "<e2>", ",", "trigeminal", "anesthesia", "scalp", "alopecia", "cerebellar", "anomaly", "midface", "hypoplasia", "corneal", "opacities", "apparently", "low-set", "ears", "mental", "retardation", "and", "short", "stature"], "h": {"id": "C0795959", "name": "C0795959#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0004134", "name": "C0004134#ent", "pos": [9, 10]}}
{"token": ["Adverse", "effects", "the", "first", "type", "include", "bronchospasm", ",", "heart", "failure", "prolonged", "C0020616#ent", "<e1>", ",", "bradycardia", ",", "heart", "block", "intermittent", "claudication", "and", "C0151445#ent", "<e2>", "phenomenon", "."], "h": {"id": "C0020616", "name": "C0020616#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0151445", "name": "C0151445#ent", "pos": [21, 22]}}
{"token": ["Similar", "hearing", "loss", "phenotype", "was", "observed", "in", "patients", "with", "familial", "nonsyndromic", "supravalvular", "aortic", "stenosis", "C1414382#ent", "<e1>", ")", ",", "suggesting", "that", "molecular", "defects", "the", "C0013765#ent", "<e2>", "the", "pathogenesis", "of", "SNHL", "in", "WS", "."], "h": {"id": "C1414382", "name": "C1414382#ent", "pos": [14, 15]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [23, 24]}}
{"token": ["We", "document", "that", "FOXOA3", "enhanced", "the", "hormone-dependent", "transcriptional", "activity", "of", "liganded", "progesterone", "receptors", "A", "C1705324#ent", "<e1>", ")", "on", "a", "glucocorticoid", "response", "promoter", ",", "C1705324#ent", "<e1>", "on", "the", "C1334092#ent", "<e1>", "promoter", ",", "and", "estrogen", "receptor", "alpha", "an", "estrogen", "response", "promoter", "."], "h": {"id": "C1705324", "name": "C1705324#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1334092", "name": "C1334092#ent", "pos": [27, 28]}}
{"token": ["We", "have", "isolated", "and", "characterized", "a", "human", "C0752939#ent", "<e1>", "hGSTA4", ")", "subunit", "gene", "a", "yeast", "artificial", "chromosome", "several", "other", "C0017837#ent", "<e2>", "pseudogenes", "."], "h": {"id": "C0752939", "name": "C0752939#ent", "pos": [7, 8]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0017837", "name": "C0017837#ent", "pos": [19, 20]}}
{"token": ["We", "present", "a", "case", "of", "C0038454#ent", "<e1>", "who", "presented", "with", "features", "of", "C1848862#ent", "<e2>", "of", "inappropriate", "anti-diuretic", "hormone", "secretion", "SIADH", ")", "and", "monocular", "blindness"], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [12, 13]}}
{"token": ["However", ",", "we", "describe", "two", "patients", "with", "C0038019#ent", "<e1>", "who", "developed", "staphylococcal", "osteomyelitis", "the", "cervical", "spine", "progressive", "C0034372#ent", "<e2>", ",", "apparently", "following", "manipulation", "of", "the", "neck", "by", "a", "chiropractor", "."], "h": {"id": "C0038019", "name": "C0038019#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0034372", "name": "C0034372#ent", "pos": [17, 18]}}
{"token": ["The", "SsuDAT1I", "restriction-modification", "(", "R-M", ")", "system", ",", "which", "contains", "two", "C0033649#ent", "<e1>", "and", "two", "C0012906#ent", "<e2>", "recognition", "sequence", "'", ",", "was", "first", "found", "in", "a", "field", "isolate", "of", "Streptococcus", "suis", "serotype", "2"], "h": {"id": "C0033649", "name": "C0033649#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0012906", "name": "C0012906#ent", "pos": [15, 16]}}
{"token": ["Other", "work", "on", "enzymes", "associated", "with", "cell", "death", "aspartate", "aminotransferase", "lactate", "dehydrogenase", "and", "several", "neutrophil", "lysosomal", "enzymes", "(", "C1439345#ent", "<e1>", "arylsulphatase", ",", "cathepsins", ")", "has", "demonstrated", "positive", "associations", "between", "C0014442#ent", "<e2>", "levels", "and", "attachment", "loss", "inflammation", "."], "h": {"id": "C1439345", "name": "C1439345#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [29, 30]}}
{"token": ["The", "enzymes", "are", "C1416630#ent", "<e1>", ",", "aldolase", ",", "NAD-", "and", "NADP-dependent", "alcohol", "dehydrogenase", "C0684287#ent", "<e2>", "triokinase", "and", "glycerate", "kinase", "hexose", "biphosphatase", "sorbitol", "dehydrogenase", "also", "investigated", "."], "h": {"id": "C1416630", "name": "C1416630#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0684287", "name": "C0684287#ent", "pos": [13, 14]}}
{"token": ["Indeed", ",", "the", "inhibitory", "effect", "of", "the", "peptide", "on", "growth", "hormone", "mRNA", "levels", "was", "totally", "insensitive", "to", "C0043167#ent", "<e1>", "toxin", "treatment", "but", "was", "totally", "abolished", "under", "conditions", "which", "C1335866#ent", "<e2>", "internalization", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1335866", "name": "C1335866#ent", "pos": [28, 29]}}
{"token": ["We", "report", "here", "that", "in", "the", "rat", ",", "while", "insulin", "mRNA", "is", "detected", "in", "the", "pancreas", "as", "early", "as", "C1422634#ent", "<e1>", ",", "TRH", "mRNA", "can", "not", "be", "detected", "before", "C3811108#ent", "<e2>", "."], "h": {"id": "C1422634", "name": "C1422634#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3811108", "name": "C3811108#ent", "pos": [29, 30]}}
{"token": ["On", "the", "contrary", ",", "there", "was", "no", "difference", "regarding", "the", "mean", "C0720099#ent", "<e1>", "of", "the", "RA", "course", ",", "the", "mean", "age", "C0020437#ent", "<e2>", ",", "and", "alkaline", "phosphatases", "level", "."], "h": {"id": "C0720099", "name": "C0720099#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0020437", "name": "C0020437#ent", "pos": [21, 22]}}
{"token": ["We", "investigated", "whether", "prolonged", "C0010054#ent", "<e1>", "activation", "of", "C0010656#ent", "<e2>", "and", "whether", "this", "activation", "is", "related", "to", "cytochrome", "c", "from", "mitochondria", "to", "cytosol", "during", "ischaemia", "."], "h": {"id": "C0010054", "name": "C0010054#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0010656", "name": "C0010656#ent", "pos": [8, 9]}}
{"token": ["Together", ",", "these", "data", "indicate", "that", "C3273433#ent", "<e1>", "modulates", "IRES-dependent", "translation", "of", "C1415761#ent", "<e2>", "mRNA", "through", "an", "RNA-protein", "interaction", "under", "heat", "stress", "."], "h": {"id": "C3273433", "name": "C3273433#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1415761", "name": "C1415761#ent", "pos": [12, 13]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "estimate", "the", "drug", "interaction", "potential", "of", "psychtropic", "medication", "on", "buprenorphine", "(", "C1428040#ent", "<e1>", ")", "N-dealkylation", "using", "cDNA-expressed", "cytochrome", "P450", "(", "CYP", ")", "C3541394#ent", "<e2>", "."], "h": {"id": "C1428040", "name": "C1428040#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [30, 31]}}
{"token": ["C0039542#ent", "<e1>", "was", "found", "to", "significantly", "elevate", "plasma", "C1366564#ent", "<e2>", "titers", "in", "rabbits", "while", "producing", "a", "slight", "but", "nonsignificant", "decrease", "in", "mean", "blood", "pressure"], "h": {"id": "C0039542", "name": "C0039542#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1366564", "name": "C1366564#ent", "pos": [8, 9]}}
{"token": ["C0018213#ent", "<e1>", "an", "autoimmune", "disease", "thyroidal", "and", "extra-thyroidal", "manifestations", "such", "as", "C0014130#ent", "<e2>", "which", "is", "caused", "by", "a", "dense", "lymphocytic", "infiltrate"], "h": {"id": "C0018213", "name": "C0018213#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0014130", "name": "C0014130#ent", "pos": [11, 12]}}
{"token": ["We", "also", "found", "activation", "of", "the", "C0003402#ent", "<e1>", "gills", "and", "brain", "of", "exposed", "C3274826#ent", "<e2>", "."], "h": {"id": "C0003402", "name": "C0003402#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3274826", "name": "C3274826#ent", "pos": [13, 14]}}
{"token": ["The", "expression", "of", "a", "small", "subset", "of", "C0017337#ent", "<e1>", "is", "upregulated", "by", "C3554225#ent", "<e2>", "not", "modulated", "by", "caloric", "restriction", "and", "markedly", "suppressed", "by", "short-term", "leptin", "treatment", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3554225", "name": "C3554225#ent", "pos": [12, 13]}}
{"token": ["Here", ",", "after", "a", "brief", "analysis", "on", "clinical", "indications", "on", "the", "last", "generation", "C0012544#ent", "<e1>", "(", "N-BP", ")", "and", "on", "biochemical", "pathways", "molecular", "targets", "C1849718#ent", "<e2>", ",", "we", "will", "discuss", "the", "molecular", "mechanisms", "these", "antitumor", "effects"], "h": {"id": "C0012544", "name": "C0012544#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1849718", "name": "C1849718#ent", "pos": [24, 25]}}
{"token": ["We", "engineered", "an", "C2239763#ent", "<e1>", "fragment", "containing", "the", "C1416810#ent", "<e2>", "devoid", "of", "a", "catalytic", "domain", "explore", "how", "myosin", "is", "stimulated", "by", "this", "non-kinase", "pathway", "."], "h": {"id": "C2239763", "name": "C2239763#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1416810", "name": "C1416810#ent", "pos": [8, 9]}}
{"token": ["This", "study", "investigated", "and", "compared", "the", "effects", "of", "particle", "size", "reduction", "on", "the", "C0003277#ent", "<e1>", "carrot", "insoluble", "fiber-rich", "fraction", "(", "C0020823#ent", "<e2>", ")", "and", "plant", "cellulose"], "h": {"id": "C0003277", "name": "C0003277#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [20, 21]}}
{"token": ["The", "presence", "of", "AADC", "autoantibodies", "patients", "with", "C0085859#ent", "<e1>", "a", "subgroup", "of", "C0002892#ent", "<e2>", "patients", "who", "may", "have", "a", "milder", "atypical", "form", "of", "C0085859#ent", "<e1>", "represent", "a", "distinct", "entity", "."], "h": {"id": "C0085859", "name": "C0085859#ent", "pos": [7, 8]}, "relation": "has_manifestation", "t": {"id": "C0002892", "name": "C0002892#ent", "pos": [12, 13]}}
{"token": ["Maximum", "effects", "with", "serum-inactivated", "HF", "extract", "were", "achieved", "with", "2", "C1313497#ent", "<e1>", "equivalents", "containing", "2.6", "ng", "of", "C1705225#ent", "<e2>", "."], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705225", "name": "C1705225#ent", "pos": [17, 18]}}
{"token": ["Paeonol", ",", "a", "major", "C0031428#ent", "<e1>", "component", "of", "C0001614#ent", "<e2>", "was", "known", "to", "have", "antiaggregatory", ",", "antioxidant", "and", "antiinflammatory", "activities"], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [8, 9]}}
{"token": ["Only", "for", "a", "succinic", "acid", "C0013227#ent", "<e1>", ">", "or", "=", "5", "was", "C0700481#ent", "<e2>", "release", "constant", "for", "6", "-", "8", "h", "and", "independent", "of", "the", "pH-value", "of", "dissolution", "media", "."], "h": {"id": "C0013227", "name": "C0013227#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0700481", "name": "C0700481#ent", "pos": [12, 13]}}
{"token": ["Chromatin", "immunoprecipitation", "C1420492#ent", "<e1>", ")", "in", "HCT116", "cells", "their", "hypermethylated", "variant", "showed", "that", "C3812165#ent", "<e2>", "binds", "to", "methylated", "DNA", "sequences", "whereas", "CTCF", "binds", "to", "unmethylated", "DNA", "."], "h": {"id": "C1420492", "name": "C1420492#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3812165", "name": "C3812165#ent", "pos": [13, 14]}}
{"token": ["Statistically", "significant", "negative", "correlation", "between", "Kt/V", "and", "C1705593#ent", "<e1>", "was", "found", "only", "in", "C0171406#ent", "<e2>", "subjects", "(", "r=-0.466", ",", "p", "=", "0.010", ")", "."], "h": {"id": "C1705593", "name": "C1705593#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0171406", "name": "C0171406#ent", "pos": [13, 14]}}
{"token": ["C0770456#ent", "<e1>", "increased", "in", "vivo", "phosphoinositide", "(", "PI", ")", "hydrolysis", "in", "C0001614#ent", "<e2>", ",", "striatum", ",", "and", "to", "the", "greatest", "extent", "in", "the", "hippocampus", "."], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "arginine", "vasopressin", "C1706109#ent", "<e1>", ")", "on", "rat", "renal", "ornithine", "decarboxylase", "C1704862#ent", "<e2>", ")", "activity", "was", "investigated", "by", "a", "cytochemical", "technique", "for", "use", "in", "the", "medullary", "thick", "ascending", "limb", "of", "Henle's", "loop", "mTAL", ")", "."], "h": {"id": "C1706109", "name": "C1706109#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704862", "name": "C1704862#ent", "pos": [13, 14]}}
{"token": ["In", "addition", ",", "introduction", "of", "a", "constitutively", "active", "C0173879#ent", "<e1>", "enhanced", "ALP", "activity", "in", "the", "absence", "of", "C0009325#ent", "<e2>", "production", "."], "h": {"id": "C0173879", "name": "C0173879#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [17, 18]}}
{"token": ["The", "LRIG2", "amino", "acid", "sequence", "47", "%", "identical", "to", "human", "LRIG1", "and", "mouse", "C1424933#ent", "<e1>", "(", "also", "known", "as", "C2697911#ent", "<e2>", ")", "."], "h": {"id": "C1424933", "name": "C1424933#ent", "pos": [13, 14]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2697911", "name": "C2697911#ent", "pos": [19, 20]}}
{"token": ["Oncogenic", "Ras", "is", "known", "to", "block", "differentiation", "C2C12", "cells", "via", "downregulation", "of", "MyoD.", "Reexpression", "of", "C1332740#ent", "<e1>", "in", "C2C12/Ras", "cells", "induces", "C1417574#ent", "<e2>", ";", "conversely", ",", "C1417574#ent", "<e2>", "induces", "C1332740#ent", "<e1>", "."], "h": {"id": "C1417574", "name": "C1417574#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1332740", "name": "C1332740#ent", "pos": [15, 16]}}
{"token": ["The", "concentration", "of", "1-nitropyrene", "was", "measured", "after", "reduction", "by", "a", "specific", "C0028195#ent", "<e1>", "purified", "from", "C1456246#ent", "<e2>"], "h": {"id": "C0028195", "name": "C0028195#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1456246", "name": "C1456246#ent", "pos": [15, 16]}}
{"token": ["The", "abilities", "of", "alpha", "Th", "induce", "myocyte", "hypertrophy", "to", "augment", "C1417807#ent", "<e1>", "transcription", "and", "peptide", "production", "were", "inhibited", "by", "the", "C1514555#ent", "<e2>", "chelerythrine", ",", "and", "by", "the", "tyrosine", "kinase", "inhibitor", "tyrphostin", "."], "h": {"id": "C1417807", "name": "C1417807#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1514555", "name": "C1514555#ent", "pos": [20, 21]}}
{"token": ["Cisapride-induced", "gastric", "motility", "was", "inhibited", "by", "C1161352#ent", "<e1>", "and", "acute", "vagal", "blockade", "but", "not", "by", "C0061851#ent", "<e2>", "."], "h": {"id": "C1161352", "name": "C1161352#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0061851", "name": "C0061851#ent", "pos": [15, 16]}}
{"token": ["Administration", "of", "endosulfan", "significantly", "increased", "C0251914#ent", "<e1>", "cytochrome", "P-450", "content", "and", "the", "activity", "of", "C0002587#ent", "<e2>"], "h": {"id": "C0251914", "name": "C0251914#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0002587", "name": "C0002587#ent", "pos": [14, 15]}}
{"token": ["The", "differential", "expression", "observed", "in", "neurons", "and", "fibroblasts", "suggests", "that", "the", "C1416797#ent", "<e1>", "genes", "play", "a", "C1880904#ent", "<e2>", "role", "during", "development", "."], "h": {"id": "C1416797", "name": "C1416797#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [16, 17]}}
{"token": ["A", "paramount", "question", "in", "spinal", "muscular", "atrophy", "SMA", ")", "research", "is", "why", "reduced", "levels", "of", "C1416797#ent", "<e1>", ",", "a", "ubiquitously", "expressed", "protein", ",", "leads", "to", "a", "C1880904#ent", "<e2>"], "h": {"id": "C1416797", "name": "C1416797#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [26, 27]}}
{"token": ["This", "study", "was", "performed", "to", "determine", "changes", "in", "RIF", "C0043388#ent", "<e1>", "and", "AngII", "concentrations", "during", "interstitial", "administration", "ACE", "inhibitors", "C0014025#ent", "<e2>", "and", "perindoprilat", ")", "."], "h": {"id": "C0043388", "name": "C0043388#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0014025", "name": "C0014025#ent", "pos": [19, 20]}}
{"token": ["The", "experiments", "have", "shown", "that", "C0275524#ent", "<e1>", "E.", "coli", "uncommon", "even", "when", "both", "pathogens", "are", "equally", "C0022658#ent", "<e2>", "and", "are", "introduced", "simultaneously", "into", "the", "bladder", "."], "h": {"id": "C0275524", "name": "C0275524#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [16, 17]}}
{"token": ["The", "mutation", "of", "TRK-T3", "tyrosine", "291", ",", "docking", "site", "both", "C1705297#ent", "<e1>", "and", "FRS2", ",", "abrogates", "the", "C1417123#ent", "<e2>", "biological", "activity"], "h": {"id": "C1705297", "name": "C1705297#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417123", "name": "C1417123#ent", "pos": [17, 18]}}
{"token": ["Exposure", "to", "occupational", "vibration", "\"", "white", "finger", "syndrome", "or", "C0034734#ent", "<e1>", "phenomenon", "together", "with", "C0007820#ent", "<e2>"], "h": {"id": "C0034734", "name": "C0034734#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [14, 15]}}
{"token": ["Reversibility", "was", "also", "observed", "with", "both", "C2987364#ent", "<e1>", "P450", "2B4", "the", "T302A", "mutant", "of", "C3538766#ent", "<e2>", ",", "although", "this", "inactivation", "and", "reversibility", "did", "not", "seem", "to", "depend", "on", "the", "T302", "residue", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3538766", "name": "C3538766#ent", "pos": [14, 15]}}
{"token": ["Lysozymuria", "was", "studied", "in", "70", "patients", "with", "C0085697#ent", "<e1>", "preserved", "renal", "function", "two", "groups", "of", "18", "patients", "each", "with", "C0034186#ent", "<e2>", ",", "with", "chronic", "renal", "insufficiency", "CRI", ")", "and", "glomerulonephritis", "without", "CRI", "."], "h": {"id": "C0085697", "name": "C0085697#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [19, 20]}}
{"token": ["Mif1", "contains", "a", "ubiquitin-like", "domain", "is", "most", "probably", "involved", "in", "binding", "to", "C4049859#ent", "<e1>", ",", "a", "subunit", "of", "the", "19S", "regulatory", "complex", "the", "C0286330#ent", "<e2>"], "h": {"id": "C4049859", "name": "C4049859#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0286330", "name": "C0286330#ent", "pos": [23, 24]}}
{"token": ["With", "delayed", "kinetics", ",", "C1420816#ent", "<e1>", "promotes", "the", "processing", "of", "C2987236#ent", "<e2>", "to", "p52", "and", "sustained", "formation", "of", "p52/RelB", "complexes", "via", "the", "alternative", "NF-kappaB", "pathway"], "h": {"id": "C1420816", "name": "C1420816#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C2987236", "name": "C2987236#ent", "pos": [10, 11]}}
{"token": ["The", "rhythmic", "discharges", "produced", "by", "the", "MLR", "stimulation", "were", "recorded", "from", "hindlimb", "extensor", "muscle", "C0238111#ent", "<e1>", ":", "lateral", "gastrocnemius", "soleus", ")", "and", "flexor", "muscle", "C1823521#ent", "<e2>", ":", "posterior", "biceps", "semitendinosus", ")", "nerves", "."], "h": {"id": "C0238111", "name": "C0238111#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1823521", "name": "C1823521#ent", "pos": [24, 25]}}
{"token": ["Expression", "of", "ferritin", "light", "chain", "rhoA", ",", "inosine", "monophosphatdgehydrogenase", "II", "C1335649#ent", "<e1>", "pro2000", "and", "pro1859", "were", "increased", "after", "drug", "treatment", "whereas", "C1335208#ent", "<e2>", "and", "alpha-actinin", "expressions", "were", "significantly", "downregulated", "."], "h": {"id": "C1335649", "name": "C1335649#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1335208", "name": "C1335208#ent", "pos": [21, 22]}}
{"token": ["This", "prompted", "us", "to", "examine", "the", "involvement", "of", "C1958958#ent", "<e1>", "in", "the", "regulation", "of", "C1706349#ent", "<e2>", "expression", "in", "tumor", "hypoxia"], "h": {"id": "C1958958", "name": "C1958958#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1706349", "name": "C1706349#ent", "pos": [14, 15]}}
{"token": ["Site-directed", "mutagenesis", "the", "large", "fragment", "of", "C0012888#ent", "<e1>", "Klenow", "fragment", "yielded", "two", "C1564139#ent", "<e2>", "3',5'-exonuclease", "activity", "having", "normal", "polymerase", "activity"], "h": {"id": "C0012888", "name": "C0012888#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1564139", "name": "C1564139#ent", "pos": [12, 13]}}
{"token": ["Sulphapyridine", ",", "auranofin", ",", "C0596007#ent", "<e1>", "and", "methotrexate", ",", "had", "no", "effect", "C1705592#ent", "<e2>", "secretion", "in", "endothelial", "cells"], "h": {"id": "C0596007", "name": "C0596007#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [12, 13]}}
{"token": ["The", "C1706475#ent", "<e1>", "significantly", "reduced", "the", "teratogenic", "potential", "of", "C2348923#ent", "<e2>", "by", "a", "TI", "factor", "2.7", "."], "h": {"id": "C1706475", "name": "C1706475#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2348923", "name": "C2348923#ent", "pos": [9, 10]}}
{"token": ["These", "include", "nail", "matrix", "nevi", ";", "physical", "induction", "secondary", "to", "trauma", ";", "malignant", "melanoma", "nutritional", "deficiencies", "inflammation", "secondary", "to", "C0023646#ent", "<e1>", "endocrine", "causes", "such", "as", "C0001403#ent", "<e2>", "or", "secondary", "to", "bacterial", ",", "fungal", ",", "or", "viral", "infections"], "h": {"id": "C0023646", "name": "C0023646#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [25, 26]}}
{"token": ["Capecitabine", "was", "converted", "to", "5'-DFUR", "by", "either", "human", "carboxyestelase", "C1413247#ent", "<e1>", "which", "were", "mainly", "localized", "in", "human", "C0023899#ent", "<e2>", "."], "h": {"id": "C1413247", "name": "C1413247#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [17, 18]}}
{"token": ["Systemic", "injection", "of", "C0031495#ent", "<e1>", "(", "PPA", ")", ",", "an", "alpha", "1-adrenergic", "receptor", "C2987634#ent", "<e2>", "with", "some", "activity", "at", "alpha", "2-adrenergic", "receptors", "suppresses", "food", "intake", "rats", "."], "h": {"id": "C0031495", "name": "C0031495#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [13, 14]}}
{"token": ["By", "Western", "blotting", "C0172537#ent", "<e1>", "was", "detected", "in", "odontoblasts", "and", "C0399408#ent", "<e2>", "both", "sound", "and", "carious", "teeth", "in", "dentinal", "fluid", "dentin", "of", "sound", "teeth", "but", "not", "in", "soft", "carious", "dentin", "."], "h": {"id": "C0172537", "name": "C0172537#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0399408", "name": "C0399408#ent", "pos": [10, 11]}}
{"token": ["Formulating", "topical", "combination", "therapies", "moisturizers", "and", "C0003417#ent", "<e1>", "can", "significantly", "reduce", "the", "itch", "associated", "with", "C0720057#ent", "<e2>"], "h": {"id": "C0003417", "name": "C0003417#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0720057", "name": "C0720057#ent", "pos": [15, 16]}}
{"token": ["In", "vitro", "Bcl-xL", "and", "C0376515#ent", "<e1>", "were", "poor", "substrates", "relative", "to", "c-Jun", "and", "C1332119#ent", "<e2>", "for", "active", "recombinant", "JNK1", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332119", "name": "C1332119#ent", "pos": [13, 14]}}
{"token": ["Treatment", ",", "therefore", ",", "should", "essentially", "be", "based", "on", "C0003280#ent", "<e1>", "and", "antiaggregant", "therapy", ",", "so", "as", "to", "prevent", "ischemic", "attacks", "C0007274#ent", "<e2>"], "h": {"id": "C0003280", "name": "C0003280#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007274", "name": "C0007274#ent", "pos": [21, 22]}}
{"token": ["The", "atopic", "and", "C0023897#ent", "<e1>", "as", "well", "as", "hipereosinophilic", "syndrome", "C0020352#ent", "<e2>", ")", "are", "the", "most", "typical", "processes", "in", "which", "they", "take", "part", "."], "h": {"id": "C0023897", "name": "C0023897#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0020352", "name": "C0020352#ent", "pos": [10, 11]}}
{"token": ["C0030956#ent", "<e1>", "were", "designed", "to", "be", "selective", "for", "TR", "over", "human", "C0017824#ent", "<e2>", "GR", ")", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017824", "name": "C0017824#ent", "pos": [11, 12]}}
{"token": ["Thus", ",", "C1418458#ent", "<e1>", "appears", "to", "be", "the", "most", "common", "C0017337#ent", "<e2>", "associated", "with", "in", "Australian", "families", "."], "h": {"id": "C1418458", "name": "C1418458#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [10, 11]}}
{"token": ["COX-deficient", "skeletal", "muscle", "contained", "supra-threshold", "levels", "of", "multiple", "mtDNA", "deletions", ",", "and", "genetic", "linkage", "sequencing", "and", "expression", "analysis", "POLG1", ",", "C1418458#ent", "<e1>", "and", "SLC25A4", ",", "the", "C0017337#ent", "<e2>", "encoding", "Ant", "1", "as", "the", "cause", "."], "h": {"id": "C1418458", "name": "C1418458#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [26, 27]}}
{"token": ["Proteinuria", "was", "prominent", "in", "SHR/NDmcr-cp", "compared", "with", "nonobese", "SHR", ",", "which", "was", "accompanied", "by", "podocyte", "injury", "evidenced", "by", "foot", "process", "effacement", "induction", "of", "C1413980#ent", "<e1>", "and", "attenuation", "of", "C1417784#ent", "<e2>", "."], "h": {"id": "C1413980", "name": "C1413980#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1417784", "name": "C1417784#ent", "pos": [28, 29]}}
{"token": ["C0080151#ent", "<e1>", "also", "elevate", "the", "level", "of", "C0669516#ent", "<e2>", "cells", "."], "h": {"id": "C0080151", "name": "C0080151#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669516", "name": "C0669516#ent", "pos": [7, 8]}}
{"token": ["A", "clinical", "trial", "the", "drug", "was", "performed", "in", "11", "patients", ",", "8", "with", "nephrotic", "syndrome", "1", "with", "oedema", "and", "ascites", "due", "to", "C0023890#ent", "<e1>", "and", "2", "with", "congestive", "cardiac", "failure", "to", "C1449563#ent", "<e2>"], "h": {"id": "C0023890", "name": "C0023890#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1449563", "name": "C1449563#ent", "pos": [31, 32]}}
{"token": ["However", ",", "after", "C1336929#ent", "<e1>", ",", "two", "died", "of", "C0243026#ent", "<e2>", "and", "two", "survivors", "had", "caval", "abscess"], "h": {"id": "C1336929", "name": "C1336929#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0243026", "name": "C0243026#ent", "pos": [9, 10]}}
{"token": ["Synchronized", "FDC-P1", "cells", "exhibited", "modulation", "of", "C1334087#ent", "<e1>", "expression", "through", "C1539078#ent", "<e2>", "both", "by", "quantitative", "RT-PCR", "flow", "cytometry"], "h": {"id": "C1334087", "name": "C1334087#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [10, 11]}}
{"token": ["A", "deletion", "of", "Lobe", "A", "COG", "subunits", "in", "yeasts", "causes", "severe", "growth", "defects", "mutations", "in", "COG1", ",", "C1425654#ent", "<e1>", ",", "and", "COG8", "in", "humans", "cause", "novel", "types", "of", "C0543793#ent", "<e2>", "glycosylation", "."], "h": {"id": "C1425654", "name": "C1425654#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0543793", "name": "C0543793#ent", "pos": [28, 29]}}
{"token": ["The", "complete", "nucleotide", "(nt)", "of", "two", "Bacillus", "megaterium", "genes", "for", "small", ",", "C1412739#ent", "<e1>", "SASP", ")", ",", "termed", "C1418485#ent", "<e2>", "and", "C-2", ",", "has", "been", "determined", "."], "h": {"id": "C1412739", "name": "C1412739#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1418485", "name": "C1418485#ent", "pos": [18, 19]}}
{"token": ["We", "sought", "to", "compare", "the", "prevalence", "of", "systemic", "disease", "C0024140#ent", "<e1>", "SCLE", ")", "with", "systemic", "lupus", "erythematosus", "C0024141#ent", "<e2>", ")", "."], "h": {"id": "C0024140", "name": "C0024140#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0024141", "name": "C0024141#ent", "pos": [17, 18]}}
{"token": ["Of", "importance", ",", "a", "90", "%", "RNAi", "knockdown", "of", "C3541976#ent", "<e1>", "reduced", "EBNALP", "coactivation", "with", "C3641847#ent", "<e2>", "of", "transfected", "EBV", "LMP1", "and", "Cp", "promoters", "by", "approximately", "50", "%", "."], "h": {"id": "C3541976", "name": "C3541976#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3641847", "name": "C3641847#ent", "pos": [15, 16]}}
{"token": ["C0013264#ent", "<e1>", "DMD", ")", "is", "a", "C0154671#ent", "<e2>", "the", "skeletal", "muscle", "human", "and", "is", "caused", "by", "mutations", "in", "the", "dystrophin", "gene"], "h": {"id": "C0013264", "name": "C0013264#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0154671", "name": "C0154671#ent", "pos": [6, 7]}}
{"token": ["Microorganisms", "including", "Bacteroides", "bivius", "Bacteroides", "melaninogenicus", "C1456246#ent", "<e1>", "Staphylococcus", "aureus", "Staphylococcus", "epidermidis", "Pseudomonas", "aeruginosa", "Proteus", "species", "and", "Propionibacterium", "acnes", "various", "C1947941#ent", "<e2>", "."], "h": {"id": "C1456246", "name": "C1456246#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1947941", "name": "C1947941#ent", "pos": [20, 21]}}
{"token": ["The", "actions", "of", "four", "C0178601#ent", "<e1>", "apomorphine", ",", "bromocriptine", ",", "C0035629#ent", "<e2>", ",", "piribedil", ")", "on", "a", "conditioned", "avoidance", "response", "studied", "in", "normoxic", "or", "hypobaric", "hypoxic", "rats", "."], "h": {"id": "C0178601", "name": "C0178601#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035629", "name": "C0035629#ent", "pos": [10, 11]}}
{"token": ["There", "were", "no", "statistically", "significant", "correlations", "between", "the", "presence", "of", "C0267964#ent", "<e1>", "and", "the", "different", "C0037274#ent", "<e2>", "for", "thrombocytopenia", "(", "P", "=", "0.0005", ")", "."], "h": {"id": "C0267964", "name": "C0267964#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0037274", "name": "C0037274#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "the", "effects", "of", "short-term", "C0907956#ent", "<e1>", "treatment", "on", "cardiac", "function", "pulmonary", "edema", "long-term", "evolution", "of", "heart", "failure", "C1538440#ent", "<e2>", ")", "in", "a", "rat", "model", "of", "myocardial", "infarction", "MI", ")", "."], "h": {"id": "C0907956", "name": "C0907956#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [19, 20]}}
{"token": ["We", "sought", "to", "investigate", "the", "efficacy", "and", "safety", "of", "C0907956#ent", "<e1>", ",", "a", "dual", "endothelin", "receptor", "antagonist", "in", "patients", "hospitalized", "for", "acute", "heart", "failure", "C1538440#ent", "<e2>", ")", "."], "h": {"id": "C0907956", "name": "C0907956#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1538440", "name": "C1538440#ent", "pos": [24, 25]}}
{"token": ["The", "objective", "was", "to", "compare", "the", "contribution", "to", "perinatal", "bilirubinemia", "hemolysis", "and", "C1259497#ent", "<e1>", "(", "UGT", ")", "gene", "promoter", "polymorphism", "seen", "in", "C0017551#ent", "<e2>", "between", "glucose-6-phosphate", "dehydrogenase", "and", "-normal", "neonates", "."], "h": {"id": "C1259497", "name": "C1259497#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017551", "name": "C0017551#ent", "pos": [22, 23]}}
{"token": ["The", "various", "etiological", "possibilities", "resulting", "in", "the", "manifestation", "of", "C0013604#ent", "<e1>", "this", "case", "of", "C0035334#ent", "<e2>", "considered", "."], "h": {"id": "C0013604", "name": "C0013604#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [14, 15]}}
{"token": ["Cogan's", "syndrome", "been", "described", "as", "entity", "of", "progressive", "deafness", "and", "C0155088#ent", "<e1>", "variable", "cardiovascular", "involvement", "leading", "to", "C0158617#ent", "<e2>", "orificial", "stenosis", "of", "coronary", "or", "aortic", "arch", "vessels"], "h": {"id": "C0155088", "name": "C0155088#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0158617", "name": "C0158617#ent", "pos": [17, 18]}}
{"token": ["Early", "and", "aggressive", "fluid", "resuscitation", "with", "C0020554#ent", "<e1>", "clinical", "end-points", "should", "be", "investigated", "in", "patients", "with", "C0242966#ent", "<e2>", "sepsis", ",", "and", "septic", "shock"], "h": {"id": "C0020554", "name": "C0020554#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242966", "name": "C0242966#ent", "pos": [16, 17]}}
{"token": ["C0020554#ent", "<e1>", "be", "an", "effective", "treatment", "for", "systemic", "inflammatory", "response", "syndrome", "C0242966#ent", "<e2>", ")", "."], "h": {"id": "C0020554", "name": "C0020554#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0242966", "name": "C0242966#ent", "pos": [11, 12]}}
{"token": ["Concurrent", "with", "the", "rise", "in", "obesity", ",", "C0400966#ent", "<e1>", "recognized", "as", "the", "leading", "cause", "of", "C0002484#ent", "<e2>", "elevations", "in", "obese", "youth", "."], "h": {"id": "C0400966", "name": "C0400966#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0002484", "name": "C0002484#ent", "pos": [15, 16]}}
{"token": ["C1420686#ent", "<e1>", "is", "an", "evolutionarily", "conserved", "C0021699#ent", "<e2>", "multiple", "membrane-spanning", "segments", "and", "is", "predominantly", "localized", "to", "intracellular", "membranes", ",", "similar", "to", "Bcl-2", "family", "proteins"], "h": {"id": "C1420686", "name": "C1420686#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}}
{"token": ["The", "proportion", "of", "isolates", "susceptible", "to", "linezolid", ",", "C0526513#ent", "<e1>", ",", "fosfomycin", "and", "C0028156#ent", "<e2>", "was", "100", "%", ",", "98.7", "%", ",", "98.7", "%", "and", "78.7", "%", ",", "respectively", "."], "h": {"id": "C0526513", "name": "C0526513#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0028156", "name": "C0028156#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "the", "binding", "of", "fructose-6-P", "or", "MgATP2-", "on", "the", "polarization", "fluorescence", "the", "emission", "of", "Trp88", "in", "C3540810#ent", "<e1>", "indicates", "changes", "in", "the", "local", "mobility", "the", "Trp88", "in", "both", "C0026741#ent", "<e2>"], "h": {"id": "C3540810", "name": "C3540810#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [30, 31]}}
{"token": ["In", "LQT1", ",", "physical", "stress", "more", "likely", "induce", "C0040479#ent", "<e1>", "in", "the", "C1859062#ent", "<e2>", ",", "which", "is", "more", "sensitive", "to", "emotional", "stress"], "h": {"id": "C0040479", "name": "C0040479#ent", "pos": [8, 9]}, "relation": "manifestation_of", "t": {"id": "C1859062", "name": "C1859062#ent", "pos": [12, 13]}}
{"token": ["The", "reaction", "is", "potentiated", "by", "C0242702#ent", "<e1>", "the", "group", "of", "neuroleptics", "(", "specifically", "C0031184#ent", "<e2>", "and", "thioridazine", ")", "."], "h": {"id": "C0242702", "name": "C0242702#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0031184", "name": "C0031184#ent", "pos": [13, 14]}}
{"token": ["Two", "of", "the", "persisting", "controversies", "concerning", "C0024591#ent", "<e1>", "MH", ")", "are", "discussed", ":", "storing", "and", "dosage", "of", "C0010976#ent", "<e2>", "and", "preoperative", "tactics", "to", "be", "followed", "with", "patients", "who", "are", "MH-susceptible", "."], "h": {"id": "C0024591", "name": "C0024591#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0010976", "name": "C0010976#ent", "pos": [17, 18]}}
{"token": ["Under", "halothane", ",", "the", "C0024591#ent", "<e1>", "animals", "had", "significantly", "augmented", "dantrolene", "response", "compared", "to", "MHR", "pigs", ",", "but", "three", "C0024591#ent", "<e1>", "animals", "had", "developed", "the", "MH", "syndrome", "to", "receiving", "C0010976#ent", "<e1>", "."], "h": {"id": "C0024591", "name": "C0024591#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0010976", "name": "C0010976#ent", "pos": [29, 30]}}
{"token": ["In", "1855", "Bernard", "described", "glucose", "as", "an", "internal", "secretion", "the", "liver", "and", "C0001403#ent", "<e1>", "reported", "the", "effects", "of", "C0001621#ent", "<e2>", "man", "."], "h": {"id": "C0001403", "name": "C0001403#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0001621", "name": "C0001621#ent", "pos": [18, 19]}}
{"token": ["Since", "C0020538#ent", "<e1>", "a", "high", "correlation", "with", "cardiovascular", "events", "expectations", "that", "C0248719#ent", "<e2>", ",", "a", "long-acting", "angiotensin-II", "type-1", "receptor", "blocker", "(", "ARB", ")", ",", "can", "improve", "cardiovascular", "mortality", "high", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [1, 2]}, "relation": "may_be_treated_by", "t": {"id": "C0248719", "name": "C0248719#ent", "pos": [11, 12]}}
{"token": ["As", "controls", ",", "we", "used", "extracts", "from", "C0221228#ent", "<e1>", "milia", "and", "epidermal", "inclusion", "cysts", "follicular", "extracts", "acne", "rosacea", "lesions", ",", "pustules", "of", "C0275798#ent", "<e2>", "extracts", "from", "normal", "follicles", "acne-prone", "individuals", "."], "h": {"id": "C0221228", "name": "C0221228#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0275798", "name": "C0275798#ent", "pos": [22, 23]}}
{"token": ["These", "findings", "suggest", "that", "the", "proportion", "of", "NK", "cells", "C1705977#ent", "<e1>", "and", "CD158b", ",", "but", "not", "CD158a", "nor", "C1416652#ent", "<e2>", ",", "is", "influenced", "by", "zygosity", "for", "the", "HLA-Cw7", "(", "NK1", "ligand", "haplotype", "."], "h": {"id": "C1705977", "name": "C1705977#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1416652", "name": "C1416652#ent", "pos": [18, 19]}}
{"token": ["Intestinal", "pseudoobstruction", "C1112565#ent", "<e1>", "uncommon", "complications", "of", "progressive", "C0036421#ent", "<e2>"], "h": {"id": "C1112565", "name": "C1112565#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0036421", "name": "C0036421#ent", "pos": [8, 9]}}
{"token": ["Less", "than", "100", "organisms", "of", "an", "C1875400#ent", "<e1>", "cultured", "from", "apparently", "normal", "pigs", "caused", "C0275522#ent", "<e2>", "1-day-old", "piglets", "after", "intranasal", "inoculation"], "h": {"id": "C1875400", "name": "C1875400#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0275522", "name": "C0275522#ent", "pos": [14, 15]}}
{"token": ["Tracer", "flux", "measurements", "showed", "that", "ACh", "is", "transported", "by", "C1706343#ent", "<e1>", "and", "OCT2", "but", "not", "by", "C1420138#ent", "<e2>", "."], "h": {"id": "C1706343", "name": "C1706343#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1420138", "name": "C1420138#ent", "pos": [16, 17]}}
{"token": ["To", "this", "end", ",", "we", "studied", "the", "effects", "on", "sleep", "of", "an", "AD", "C0597607#ent", "<e1>", "nitrobenzyl-thio-inosine", "(", "NBTI", ")", "and", "A1", "and", "A2A", "receptor", "C0243192#ent", "<e2>", "by", "microdialyzing", "them", "into", "the", "LPOA", "."], "h": {"id": "C0597607", "name": "C0597607#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [24, 25]}}
{"token": ["Excessive", "wall", "stretch", "distensible", "hollow", "organs", "cardiovascular", "and", "urinary", "systems", "activate", "C0127082#ent", "<e1>", "MMPs", ")", ",", "thereby", "releasing", "matrix", "neoepitopes", "and", "C0812325#ent", "<e2>", "leading", "to", "ERK1/2", "activation", "."], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [21, 22]}}
{"token": ["Despite", "detection", "of", "alpha-glucosidase", "in", "the", "renal", "tubules", "all", "the", "animals", "studied", ",", "the", "C0027203#ent", "<e1>", "was", "not", "detectable", "in", "C0014534#ent", "<e2>", "of", "hamsters", "or", "mice", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014534", "name": "C0014534#ent", "pos": [20, 21]}}
{"token": ["The", "effects", "of", "treatments", "on", "superoxide", "dismutase", "SOD", ")", "and", "C0017822#ent", "<e1>", "GSH-Px", ")", "in", "liver", "extracts", "homogenates", ",", "and", "on", "alkaline", "phosphatase", "C1366565#ent", "<e2>", ")", "in", "serum", "were", "investigated", "."], "h": {"id": "C0017822", "name": "C0017822#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1366565", "name": "C1366565#ent", "pos": [23, 24]}}
{"token": ["In", "rat", "aortic", "smooth", "muscle", "cells", "platelet-derived", "growth", "factor", "PDGF", ")", "stimulated", "a", "sustained", "activation", "of", "mitogen-activated", "protein", "kinase", "C0752312#ent", "<e1>", "while", "the", "response", "to", "angiotensin", "II", "C2698414#ent", "<e2>", ")", "was", "transient", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [27, 28]}}
{"token": ["Certain", "synthetic", ",", "nonionic", ",", "block", "copolymers", "of", "polyoxypropylene", "and", "C0032483#ent", "<e1>", "are", "potent", "C1516461#ent", "<e2>", "."], "h": {"id": "C0032483", "name": "C0032483#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1516461", "name": "C1516461#ent", "pos": [14, 15]}}
{"token": ["The", "human", "C0071511#ent", "<e1>", "SMO(PAOh1", ")", ",", "is", "one", "C0014442#ent", "<e2>", "that", "may", "play", "a", "direct", "role", "in", "the", "cellular", "response", "the", "antitumour", "polyamine", "analogues", "."], "h": {"id": "C0071511", "name": "C0071511#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [9, 10]}}
{"token": ["Deletion", "within", "the", "C1522376#ent", "<e1>", "completion", "by", "postnatal", "day", "(PND)14", ",", "and", "loss", "of", "C1415097#ent", "<e2>", "complete", "by", "PND21", "."], "h": {"id": "C1522376", "name": "C1522376#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1415097", "name": "C1415097#ent", "pos": [14, 15]}}
{"token": ["C0023529#ent", "<e1>", "for", "66", "%", "of", "abnormalities", "observed", "in", "patients", "with", "C0221165#ent", "<e2>", "other", "types", "of", "brain", "lesions", "uncommon", "."], "h": {"id": "C0023529", "name": "C0023529#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0221165", "name": "C0221165#ent", "pos": [11, 12]}}
{"token": ["We", "found", "that", "C0017789#ent", "<e1>", "stimulated", "activation", "of", "p38", "and", "C0380051#ent", "<e2>", "SAPK", ",", "also", "known", "as", "c-Jun", "N-terminal", "kinase", "JNK", ")", ")", ",", "two", "subgroup", "members", "the", "mitogen-activated", "protein", "kinase", "superfamily", "matured", "cerebellar", "granule", "cells"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0380051", "name": "C0380051#ent", "pos": [10, 11]}}
{"token": ["We", "studied", "the", "CD40-mediated", "activation", "of", "monocytes", "and", "dendritic", "cells", "patients", "affected", "with", "a", "C0398689#ent", "<e1>", "characterized", "by", "a", "defect", "of", "B", "lymphocyte", "to", "C2987634#ent", "<e2>"], "h": {"id": "C0398689", "name": "C0398689#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [24, 25]}}
{"token": ["C0127082#ent", "<e1>", "MMP", ")", "modulate", "end-organ", "complications", "of", "C0001339#ent", "<e2>", "but", "the", "correlation", "between", "increased", "MMP", "production", "and", "histological", "severity", "of", "disease", "remains", "unclear", "."], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001339", "name": "C0001339#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "C0210064#ent", "<e1>", "potently", "inhibited", "PCA", "in", "guinea", "pigs", "in", "which", "C0012694#ent", "<e2>", "and", "other", "reference", "drugs", "poor", "inhibitory", "activity", "."], "h": {"id": "C0210064", "name": "C0210064#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0012694", "name": "C0012694#ent", "pos": [12, 13]}}
{"token": ["Given", "iv", ",", "it", "prolongs", "C0012792#ent", "<e1>", "blockade", "in", "humans", "but", "the", "effects", "of", "chronic", "oral", "C0039245#ent", "<e2>", "are", "not", "known", "."], "h": {"id": "C0012792", "name": "C0012792#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0039245", "name": "C0039245#ent", "pos": [16, 17]}}
{"token": ["Interaction", "of", "M-component", "and", "nerve", "appears", "to", "have", "led", "to", "the", "C0021847#ent", "<e1>", "as", "an", "C0029166#ent", "<e2>", "Waldenstr\u00f6m's", "macroglobulinemia"], "h": {"id": "C0021847", "name": "C0021847#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0029166", "name": "C0029166#ent", "pos": [15, 16]}}
{"token": ["Furthermore", ",", "C1418938#ent", "<e1>", "stimulates", "the", "gene", "expression", "C1706383#ent", "<e2>", ",", "c-jun", ",", "and", "c-src", "."], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [8, 9]}}
{"token": ["Flavonols", "(", "quercetin", ",", "myricetin", ",", "and", "kaempferol", ")", "and", "flavones", "(", "C0912024#ent", "<e1>", "and", "luteolin", ")", "are", "the", "most", "common", "C0359916#ent", "<e2>", "in", "plant-based", "foods", "."], "h": {"id": "C0912024", "name": "C0912024#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0359916", "name": "C0359916#ent", "pos": [21, 22]}}
{"token": ["C0796074#ent", "<e1>", "adsorbs", "on", "Ag", "through", "a", "homolytic", "cleavage", "the", "S-S", "bond", "resultant", "C0001019#ent", "<e2>", "at", "the", "surface", "decomposes", "upon", "prolonged", "exposure", "to", "air", "."], "h": {"id": "C0796074", "name": "C0796074#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001019", "name": "C0001019#ent", "pos": [13, 14]}}
{"token": ["C1417108#ent", "<e1>", "may", "also", "influence", "haemopoiesis", "either", "by", "stimulating", "C0018939#ent", "<e2>", "cytokines", ",", "including", "opioids", ",", "or", "by", "directly", "affecting", "specific", "progenitor", "cells", "as", "pre-B", "cells", "monocytes", "and", "NK", "cells"], "h": {"id": "C1417108", "name": "C1417108#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018939", "name": "C0018939#ent", "pos": [9, 10]}}
{"token": ["Complete", "blindness", "occurred", "in", "four", "patients", ",", "C0750958#ent", "<e1>", "two", ",", "decreased", "visual", "acuity", "12", ",", "visual", "field", "loss", "10", "and", "C0155338#ent", "<e2>", "in", "15", "."], "h": {"id": "C0750958", "name": "C0750958#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0155338", "name": "C0155338#ent", "pos": [21, 22]}}
{"token": ["Several", "of", "the", "congenital", ",", "mitochondrial", "and", "other", "C0270984#ent", "<e1>", "spinal", "muscular", "atrophies", "recently", "recognized", "causes", "of", "C0238111#ent", "<e2>", "."], "h": {"id": "C0270984", "name": "C0270984#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0238111", "name": "C0238111#ent", "pos": [17, 18]}}
{"token": ["Human", "C3811065#ent", "<e1>", "beta-secretase", ",", "or", "BACE", ")", "belongs", "to", "the", "C2717969#ent", "<e2>", "and", "is", "responsible", "for", "generating", "the", "N-terminus", "of", "beta-amyloid", "peptide", "Abeta", ")", "."], "h": {"id": "C3811065", "name": "C3811065#ent", "pos": [1, 2]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717969", "name": "C2717969#ent", "pos": [11, 12]}}
{"token": ["C0012906#ent", "<e1>", "patterns", "corresponding", "to", "both", "the", "rbcS", "and", "cab", "multigene", "families", "C1572795#ent", "<e2>", "are", "each", "shown", "to", "segregate", "as", "single", "Mendelian", "units", "in", "the", "F(2", ")", "progeny", "of", "two", "separate", "crosses", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1572795", "name": "C1572795#ent", "pos": [12, 13]}}
{"token": ["This", "literature", "review", "a", "high", "prevalence", "of", "sympathetic", "deficits", "and", "parasympathetic", "deficits", "in", "acute", "or", "subacute", "dysautonomia", "C0011849#ent", "<e1>", ",", "amyloidosis", ",", "pure", "autonomic", "failure", "paraneoplastic", "syndromes", "C0151449#ent", "<e2>", "familial", "dysautonomia", "and", "dopamine", "beta-hydroxylase", "deficiency"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0151449", "name": "C0151449#ent", "pos": [27, 28]}}
{"token": ["MHI", "may", "also", "increase", "right", "ventricular", "load", "through", "raised", "intrathoracic", "pressures", "C1167782#ent", "<e1>", "and", "may", "therefore", "impair", "right", "ventricular", "function", "patients", "with", "evidence", "of", "C0034072#ent", "<e2>"], "h": {"id": "C1167782", "name": "C1167782#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0034072", "name": "C0034072#ent", "pos": [24, 25]}}
{"token": ["These", "results", "indicate", "that", "neuroactive", "steroids", "C0022614#ent", "<e1>", "cytotoxicity", "by", "modulation", "of", "Ca(2+)", "influx", "through", "C0022614#ent", "<e1>", "C3640117#ent", "<e1>"], "h": {"id": "C0022614", "name": "C0022614#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3640117", "name": "C3640117#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "C1419277#ent", "<e1>", "catenin", "association", "with", "C0126593#ent", "<e2>", "is", "decreased", "in", "RhoAV14-expressing", "cells", ",", "which", "is", "partially", "reverted", "by", "the", "inhibition", "of", "the", "RhoA", "effector", "Rho-associated", "kinase", "ROCK"], "h": {"id": "C1419277", "name": "C1419277#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0126593", "name": "C0126593#ent", "pos": [7, 8]}}
{"token": ["Moreover", "some", "C0003299#ent", "<e1>", "affect", "hormone", "metabolism", "inhibiting", "or", "stimulating", "C0051169#ent", "<e2>", "."], "h": {"id": "C0003299", "name": "C0003299#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0051169", "name": "C0051169#ent", "pos": [10, 11]}}
{"token": ["In", "a", "hyperglycemic", "environment", ",", "HEPTECs", "isolated", "from", "patients", "with", "type", "2", "diabetes", "expressed", "significantly", "more", "C1420201#ent", "<e1>", "and", "the", "facilitative", "glucose", "transporter", "C3889451#ent", "<e2>", "than", "cells", "from", "healthy", "individuals", "."], "h": {"id": "C1420201", "name": "C1420201#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C3889451", "name": "C3889451#ent", "pos": [23, 24]}}
{"token": ["C0246269#ent", "<e1>", "is", "a", "bradykinin-receptor-2", "antagonist", "blocks", "bradykinin-induced", "angioedema", "in", "C0019243#ent", "<e2>", "."], "h": {"id": "C0246269", "name": "C0246269#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0019243", "name": "C0019243#ent", "pos": [10, 11]}}
{"token": ["C0004626#ent", "<e1>", "pulmonary", "tuberculosis", "chronic", "bronchitis", "the", "underlying", "C0679247#ent", "<e2>", "in", "32", "(", "78", "%", ")", "while", "advanced", "malignancies", "present", "in", "two", "others", "."], "h": {"id": "C0004626", "name": "C0004626#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0679247", "name": "C0679247#ent", "pos": [8, 9]}}
{"token": ["RT-PCR", "assay", "this", "tissue", "revealed", "overexpression", "of", "MRP1", ",", "C0069197#ent", "<e1>", "and", "GST", "pi", "mRNA", ",", "but", "neither", "C1704939#ent", "<e2>", ",", "MRP2", "nor", "MXR1", "was", "observed", "."], "h": {"id": "C0069197", "name": "C0069197#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1704939", "name": "C1704939#ent", "pos": [18, 19]}}
{"token": ["The", "importance", "of", "these", "phosphoinositide", "phosphatases", "cell", "regulation", "illustrated", "by", "multiple", "examples", "of", "their", "implications", "in", "human", "diseases", "as", "C0028860#ent", "<e1>", "X-linked", "myotubular", "myopathy", "cancer", ",", "diabetes", "or", "C0004623#ent", "<e2>"], "h": {"id": "C0028860", "name": "C0028860#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [28, 29]}}
{"token": ["Downregulation", "of", "C1537676#ent", "<e1>", "specifically", "reduced", "RAR", "but", "not", "C0919499#ent", "<e2>", "TR", ")", "activity", "."], "h": {"id": "C1537676", "name": "C1537676#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0919499", "name": "C0919499#ent", "pos": [9, 10]}}
{"token": ["C1136254#ent", "<e1>", "combinations", "of", "C1704998#ent", "<e2>", "with", "NAF", "or", "VAN", "against", "CoNS", ",", "and", "C1704998#ent", "<e2>", "with", "AMB", "or", "FLC", "against", "C.", "albicans", "were", "evaluated", "by", "a", "checkerboard", "method", "with", "serial", "twofold", "dilutions", "."], "h": {"id": "C1136254", "name": "C1136254#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1704998", "name": "C1704998#ent", "pos": [4, 5]}}
{"token": ["The", "diagnosis", "of", "C0403529#ent", "<e1>", "patients", "with", "C0022660#ent", "<e2>", "relies", "on", "the", "use", "of", "immunoassays", "to", "detect", "circulating", "anti-GBM", "antibodies", "serum", "samples", "."], "h": {"id": "C0403529", "name": "C0403529#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022660", "name": "C0022660#ent", "pos": [7, 8]}}
{"token": ["However", ",", "it", "was", "only", "the", "C0879590#ent", "<e1>", "promoter", "whose", "activation", "by", "C1307220#ent", "<e2>", "was", "fully", "blocked", "by", "the", "dominant", "negative", "mutant", "MEK1S218/222A", "and", "the", "MEK1/MEK2", "inhibitor", "PD098059", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1307220", "name": "C1307220#ent", "pos": [12, 13]}}
{"token": ["In", "monkeys", ",", "benztropine", "markedly", "attenuated", "the", "effects", "of", "C0069771#ent", "<e1>", ",", "metoclopramide", ",", "halopemide", ",", "C0040180#ent", "<e2>", "and", "mezilamine", "as", "well", "as", "haloperidol", "."], "h": {"id": "C0069771", "name": "C0069771#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040180", "name": "C0040180#ent", "pos": [16, 17]}}
{"token": ["Previous", "data", "from", "our", "group", "show", "that", "C0050537#ent", "<e1>", "ASA", ")", ",", "especially", "at", "low", "dose", "C2712370#ent", "<e2>", "the", "network", "structure", "fibrin", ",", "rendering", "it", "more", "porous", "."], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [16, 17]}}
{"token": ["C0030290#ent", "<e1>", "usually", "a", "complication", "of", "acute", "and", "C0238339#ent", "<e2>", "can", "also", "occur", "postoperatively", "or", "after", "abdominal", "trauma"], "h": {"id": "C0030290", "name": "C0030290#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0238339", "name": "C0238339#ent", "pos": [8, 9]}}
{"token": ["These", "observations", "are", "consistent", "with", "idea", "that", "post-translational", "activation", "the", "kinase", "involves", "C0031686#ent", "<e1>", "activity", ",", "whereas", "C0017373#ent", "<e2>", "off", "the", "kinase", "requires", "an", "ATP-Mg2(+)-dependent", "reaction", ",", "perhaps", "due", "to", "protein", "phosphorylation"], "h": {"id": "C0031686", "name": "C0031686#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0017373", "name": "C0017373#ent", "pos": [17, 18]}}
{"token": ["In", "organ", "bath", "preparations", "of", "vaginal", "tissue", "strips", ",", "norepinephrine-induced", "contraction", "was", "attenuated", "by", "C2699403#ent", "<e1>", "and", "alpha-2", "AR", "antagonists", "prazosin", ",", "C0257343#ent", "<e2>", ",", "delequamine", "and", "phentolamine", ")", "."], "h": {"id": "C2699403", "name": "C2699403#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0257343", "name": "C0257343#ent", "pos": [22, 23]}}
{"token": ["However", ",", "when", "expressed", "per", "gram", "body", "weight", "activities", "of", "both", "epoxide", "hydratase", "GSH", "C0537086#ent", "<e1>", "were", "3", "times", "higher", "for", "Drosophila", "C3540772#ent", "<e2>", "."], "h": {"id": "C0537086", "name": "C0537086#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [22, 23]}}
{"token": ["The", "authors", "describe", "two", "patients", ",", "one", "with", "leukemia", "who", "developed", "recurrent", "C0343386#ent", "<e1>", "another", "who", "developed", "C0011991#ent", "<e2>", "bone", "marrow", "transplantation"], "h": {"id": "C0343386", "name": "C0343386#ent", "pos": [12, 13]}, "relation": "related_to", "t": {"id": "C0011991", "name": "C0011991#ent", "pos": [17, 18]}}
{"token": ["Despite", "phototherapy", "and", "correction", "of", "polycythaemia", "by", "partial", "exchange", "transfusion", "coagulopathy", ",", "hypoglycaemia", "and", "conjugated", "C0022350#ent", "<e1>", "persisted", ",", "suggesting", "C0085605#ent", "<e2>"], "h": {"id": "C0022350", "name": "C0022350#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0085605", "name": "C0085605#ent", "pos": [20, 21]}}
{"token": ["Activation", ",", "down", "regulation", "of", "C0033634#ent", "<e1>", ",", "formation", "of", "the", "C1431394#ent", "<e2>", "as", "well", "as", "proteolytic", "processing", "cytoskeleton", "have", "been", "demonstrated", "to", "be", "correlated", "to", "those", "biochemical", "responses", "characterize", "neutrophil", "activation"], "h": {"id": "C0033634", "name": "C0033634#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1431394", "name": "C1431394#ent", "pos": [11, 12]}}
{"token": ["The", "respiratory", "effects", "induction", "of", "anaesthesia", "with", "Minaxolone", "0.4", "mg/kg", "were", "studied", "following", "premedication", "with", "either", "C0004259#ent", "<e1>", "alone", ",", "lorazepam", "and", "C0004259#ent", "<e1>", "or", "papaveretum", "and", "C0036444#ent", "<e1>", "."], "h": {"id": "C0004259", "name": "C0004259#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0036444", "name": "C0036444#ent", "pos": [27, 28]}}
{"token": ["Genetic", "linkage", "the", "C0012634#ent", "<e1>", "the", "proximal", "short", "arm", "the", "X", "chromosome", "C1705709#ent", "<e2>", ")", "where", "a", "voltage", "gated", "chloride", "channel", "gene", "CLCN5", ",", "had", "previously", "been", "mapped", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705709", "name": "C1705709#ent", "pos": [12, 13]}}
{"token": ["Migraine", "headache", "variants", "consist", "of", "the", "complicated", "C0149931#ent", "<e1>", "subtypes", "such", "as", "C0270860#ent", "<e2>", "migraine", "equivalents", ",", "and", "late-life", "migraine", "accompanients", "."], "h": {"id": "C0149931", "name": "C0149931#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0270860", "name": "C0270860#ent", "pos": [12, 13]}}
{"token": ["Accompanying", "C0018799#ent", "<e1>", "such", "as", "inner", "ear", "deafness", "G6PDH", "deficiency", "C1840402#ent", "<e2>", "and", "vitamin", "D", "intoxication", "to", "be", "excluded", "."], "h": {"id": "C0018799", "name": "C0018799#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1840402", "name": "C1840402#ent", "pos": [10, 11]}}
{"token": ["From", "C1539862#ent", "<e1>", "injection", "to", "8", "weeks", ",", "the", "serum", "levels", "of", "C0000970#ent", "<e2>", "in", "the", "diabetic", "rats", "were", "significantly", "lower", "than", "in", "controls", ",", "indicating", "delayed", "gastric", "emptying"], "h": {"id": "C1539862", "name": "C1539862#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0000970", "name": "C0000970#ent", "pos": [12, 13]}}
{"token": ["C1539791#ent", "<e1>", "examined", "in", "six", "patients", "exhibiting", "the", "characteristic", "features", "of", "C0041408#ent", "<e2>"], "h": {"id": "C1539791", "name": "C1539791#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0041408", "name": "C0041408#ent", "pos": [11, 12]}}
{"token": ["In", "this", "report", ",", "we", "describe", "the", "function", "of", "the", "Btk-binding", "protein", "Sab", "(", "C1420022#ent", "<e1>", "preferentially", "associates", "with", "C1528376#ent", "<e2>", ")", ",", "which", "we", "reported", "previously", "as", "a", "newly", "identified", "Src", "homology", "3", "domain-binding", "protein"], "h": {"id": "C1420022", "name": "C1420022#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1528376", "name": "C1528376#ent", "pos": [19, 20]}}
{"token": ["GnRH", "Analogues", "therapy", "C0017411#ent", "<e1>", "at", "suppression", "of", "physiologic", "ciclic", "ovaric", "function", "a", "C0271623#ent", "<e2>", "condition", "."], "h": {"id": "C0017411", "name": "C0017411#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [13, 14]}}
{"token": ["Here", ",", "using", "a", "simple", "high-throughput", "screening", "assay", "search", "for", "Cl-", "channels", "modulators", "in", "the", "cystic", "fibrosis", "nasal", "epithelial", "cell", "line", ",", "the", "C0018312#ent", "<e1>", "Wytensin", ")", ",", "an", "alpha2-selective", "adrenergic", "C0243192#ent", "<e2>", "was", "found", "positive", "."], "h": {"id": "C0018312", "name": "C0018312#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0243192", "name": "C0243192#ent", "pos": [31, 32]}}
{"token": ["However", ",", "EMSA", "experiments", "that", "at", "the", "concentrations", "used", ",", "C0063041#ent", "<e1>", "neither", "interferes", "with", "IL-1beta-", "nor", "with", "C1321914#ent", "<e2>", "NF-kappaB", "translocation"], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [18, 19]}}
{"token": ["The", "deduced", "amino", "acid", "sequence", "the", "C0014442#ent", "<e1>", "belongs", "to", "the", "C1955949#ent", "<e2>", "and", "is", "almost", "completely", "identical", "to", "rat", "platelet", "and", "spleen", "membrane-associated", "phospholipase", "A2"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1955949", "name": "C1955949#ent", "pos": [11, 12]}}
{"token": ["10", "%", "of", "C3273872#ent", "<e1>", "patients", "developed", "primary", "resistance", "oral", "C0038760#ent", "<e2>"], "h": {"id": "C3273872", "name": "C3273872#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [10, 11]}}
{"token": ["C0032405#ent", "<e1>", "PARP-1", ")", "activation", "and", "cysteinyl", "cathepsin", "C0057459#ent", "<e2>", "release", "from", "lysosomes", "may", "occur", "following", "SE", "as", "well", ",", "but", "these", "events", "await", "future", "investigation", "."], "h": {"id": "C0032405", "name": "C0032405#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0057459", "name": "C0057459#ent", "pos": [8, 9]}}
{"token": ["To", "further", "characterize", "cytochrome", "P450", "CYP", ")", "and", "P-glycoprotein", "(", "C1418520#ent", "<e1>", ")", "expression", "in", "C0872351#ent", "<e2>", "of", "the", "Caco-2", "cell", "clone", "TC7", ",", "a", "cell", "culture", "model", "the", "human", "intestinal", "epithelium", "."], "h": {"id": "C1418520", "name": "C1418520#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0872351", "name": "C0872351#ent", "pos": [15, 16]}}
{"token": ["N-acetyltransferase", "2", "NAT2", ")", "is", "an", "important", "C0014442#ent", "<e1>", "catalyzing", "N-acetylation", "of", "C0036078#ent", "<e2>", "(", "SASP", ")", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0036078", "name": "C0036078#ent", "pos": [12, 13]}}
{"token": ["Part", "of", "the", "influence", "may", "be", "attributed", "to", "fructose", "2,6-bisphosphate", "which", ",", "in", "some", "conditions", ",", "acts", "synergistically", "with", "C0031654#ent", "<e1>", "to", "activate", "C0031651#ent", "<e2>", "."], "h": {"id": "C0031654", "name": "C0031654#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0031651", "name": "C0031651#ent", "pos": [23, 24]}}
{"token": ["The", "non-nucleoside", "antiviral", "drugs", "discussed", "are", "arildone", ",", "C0002403#ent", "<e1>", ",", "rimantidine", ",", "moroxydine", ",", "enviroxime", ",", "C0070895#ent", "<e2>", "and", "ampligen", "."], "h": {"id": "C0002403", "name": "C0002403#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0070895", "name": "C0070895#ent", "pos": [17, 18]}}
{"token": ["The", "alpha", "6", "beta", "2", "gamma", "2", "combination", "was", "modulated", "by", "the", "C0000481#ent", "<e1>", "but", "not", "C0008188#ent", "<e2>", "."], "h": {"id": "C0000481", "name": "C0000481#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0008188", "name": "C0008188#ent", "pos": [16, 17]}}
{"token": ["Especially", ",", "only", "minor", "amounts", "of", "the", "C0031727#ent", "<e1>", "LCK", "and", "C0084219#ent", "<e2>", "are", "expressed", "in", "the", "NBS1(-/-", ")", "cell", "lines", "as", "compared", "to", "the", "consanguineous", "NBS1(+/-", ")", "cells", "."], "h": {"id": "C0031727", "name": "C0031727#ent", "pos": [7, 8]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C0084219", "name": "C0084219#ent", "pos": [11, 12]}}
{"token": ["C0001126#ent", "<e1>", "RTA", ")", "with", "nerve", "deafness", "caused", "by", "mutations", "in", "the", "C1412673#ent", "<e2>", "defective", "function", "of", "the", "H+", "-ATPase", "proton", "pump", "."], "h": {"id": "C0001126", "name": "C0001126#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1412673", "name": "C1412673#ent", "pos": [12, 13]}}
{"token": ["The", "C3539788#ent", "<e1>", "SVMT", ")", ",", "alternatively", "C1420115#ent", "<e2>", "VMAT2", ")", ",", "pumps", "cytosolic", "monoamines", "including", "dopamine", ",", "norepinephrine", ",", "serotonin", ",", "and", "histamine", "into", "synaptic", "vesicles"], "h": {"id": "C3539788", "name": "C3539788#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1420115", "name": "C1420115#ent", "pos": [7, 8]}}
{"token": ["Eleven", "erbstatin", "and", "tyrphostin", "derivatives", ",", "which", "inhibit", "epidermal", "growth", "factor", "receptor", "PTK", "activity", "by", "competing", "with", "both", "the", "peptide", "substrate", "C2744579#ent", "<e1>", "were", "tested", "for", "their", "capacity", "to", "inhibit", "C0949775#ent", "<e2>", "II", "."], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0949775", "name": "C0949775#ent", "pos": [30, 31]}}
{"token": ["The", "equivalent", "secondary", "structure", "in", "each", "of", "these", "C3540790#ent", "<e1>", "donate", "four", "C0002523#ent", "<e2>", "hydrogen", "bonds", "for", "the", "common", "orientation", "of", "the", "\"", "AMP", "\"", "moieties", "of", "their", "ATP-ligands", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0002523", "name": "C0002523#ent", "pos": [12, 13]}}
{"token": ["The", "authors", "present", "a", "case", "of", "acute", "intermittent", "porphyria", "C1412302#ent", "<e1>", ")", "in", "an", "almost", "fatal", "relapse", "with", "quadriplegia", ",", "C4082299#ent", "<e2>", "coma", "."], "h": {"id": "C1412302", "name": "C1412302#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C4082299", "name": "C4082299#ent", "pos": [20, 21]}}
{"token": ["The", "anti-cancer", "effect", "of", "C1335071#ent", "<e1>", "may", "be", "closely", "associated", "with", "dysfunction", "of", "C1332725#ent", "<e2>", "and", "our", "report", "is", "the", "first", "to", "put", "forward", "this", "point", "of", "view", "."], "h": {"id": "C1335071", "name": "C1335071#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332725", "name": "C1332725#ent", "pos": [13, 14]}}
{"token": ["We", "found", "that", "C0012383#ent", "<e1>", "(", "BAL", ")", "induced", "a", "continuous", "activation", "in", "the", "C0026837#ent", "<e2>", "and", "in", "its", "parents", "."], "h": {"id": "C0012383", "name": "C0012383#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0026837", "name": "C0026837#ent", "pos": [14, 15]}}
{"token": ["We", "assessed", "the", "efficacy", "and", "safety", "of", "C0105523#ent", "<e1>", "in", "patients", "without", "C0011849#ent", "<e2>", "who", "had", "advanced", "renal", "insufficiency"], "h": {"id": "C0105523", "name": "C0105523#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011849", "name": "C0011849#ent", "pos": [12, 13]}}
{"token": ["However", ",", "C1704665#ent", "<e1>", "increased", "within", "20", "min", "in", "rabbits", "treated", "with", "C0014994#ent", "<e2>", "maleate", "prior", "to", "GSH", "monoethyl", "ester", "."], "h": {"id": "C1704665", "name": "C1704665#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014994", "name": "C0014994#ent", "pos": [12, 13]}}
{"token": ["The", "clarified", "culture", "was", "extracted", "with", "C0059747#ent", "<e1>", "and", "two", "C0030956#ent", "<e2>", "were", "purified", "from", "the", "extract", "."], "h": {"id": "C0059747", "name": "C0059747#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [10, 11]}}
{"token": ["Furthermore", ",", "only", "P450c18", "mRNA", "was", "induced", "by", "both", "low", "C3714642#ent", "<e1>", "or", "high", "potassium", "intake", "as", "C1413856#ent", "<e2>", "mRNA", "levels", "remained", "unchanged", "."], "h": {"id": "C3714642", "name": "C3714642#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1413856", "name": "C1413856#ent", "pos": [17, 18]}}
{"token": ["Moreover", ",", "C0376515#ent", "<e1>", "transfected", "clones", "express", "elevated", "levels", "of", "C0031607#ent", "<e2>", "a", "phospholipid", "produced", "during", "receptor", "stimulated", "breakdown", "of", "phosphoinositides", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0031607", "name": "C0031607#ent", "pos": [10, 11]}}
{"token": ["Infantile", "oxalosis", "the", "most", "severe", "form", "of", "primary", "hyperoxaluria", "type", "1", "an", "inborn", "C0025517#ent", "<e1>", "by", "a", "deficiency", "of", "the", "hepatic", "enzyme", "alanine", ":", "C0061759#ent", "<e2>", "AGT", ")", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0061759", "name": "C0061759#ent", "pos": [24, 25]}}
{"token": ["C2973725#ent", "<e1>", "individuals", "with", "primary", "pulmonary", "hypertension", "congenital", "heart", "disease", "connective", "tissue", "disease", "and", "C0023895#ent", "<e2>"], "h": {"id": "C2973725", "name": "C2973725#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [14, 15]}}
{"token": ["Portopulmonary", "hypertension", "PPH", ")", "is", "clinically", "defined", "as", "the", "development", "of", "C2973725#ent", "<e1>", "by", "portal", "hypertension", "with", "or", "without", "advanced", "C0023895#ent", "<e2>"], "h": {"id": "C2973725", "name": "C2973725#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0023895", "name": "C0023895#ent", "pos": [20, 21]}}
{"token": ["Symptoms", "of", "C0014868#ent", "<e1>", "nonspecific", "and", "include", "dysphagia", ",", "C0221150#ent", "<e2>", ",", "and", "chest", "pain"], "h": {"id": "C0014868", "name": "C0014868#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0221150", "name": "C0221150#ent", "pos": [9, 10]}}
{"token": ["Among", "pre-existing", "medical", "conditions", "some", "C0027765#ent", "<e1>", "including", "multiple", "sclerosis", "other", "C0011303#ent", "<e2>", "Guillain-Barr\u00e9", "syndrome", "myasthenia", "gravis", "create", "management", "problems", "to", "travel", "medicine", "practitioners", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0011303", "name": "C0011303#ent", "pos": [11, 12]}}
{"token": ["The", "effect", "of", "tetradecanoylphorbol", "acetate", "C0256103#ent", "<e1>", ")", "on", "follicle-stimulating", "hormone", "synthesis", "of", "the", "cholesterol", "side-chain", "cleavage", "SCC", ")", "C0026741#ent", "<e2>", "studied", "in", "rat", "ovarian", "granulosa", "cells", "cultured", "for", "48", "h", "in", "serum-free", "medium"], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026741", "name": "C0026741#ent", "pos": [19, 20]}}
{"token": ["C0172870#ent", "<e1>", "and", "Crb2", "interact", "with", "C1332753#ent", "<e2>", "in", "a", "two-hybrid", "system"], "h": {"id": "C0172870", "name": "C0172870#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332753", "name": "C1332753#ent", "pos": [6, 7]}}
{"token": ["The", "contributions", "of", "histamine", ",", "cysteinyl", "leukotrienes", "CysLTs", ")", "and", "thromboxane", "A2", "TXA2", ")", "to", "the", "C0004096#ent", "<e1>", "the", "magnitudes", "of", "blood", "and", "C0014457#ent", "<e2>", "acute", "and", "chronic", "stages", "our", "asthmatic", "model", "comparatively", "determined", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0014457", "name": "C0014457#ent", "pos": [23, 24]}}
{"token": ["Such", "treatment", "can", "be", "administered", "regardless", "of", "the", "inhibitor", "titer", "in", "these", "patients", ",", "and", "C0534191#ent", "<e1>", "is", "active", "hemostatically", "in", "C0008533#ent", "<e2>", "patients", "also", "."], "h": {"id": "C0534191", "name": "C0534191#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0008533", "name": "C0008533#ent", "pos": [21, 22]}}
{"token": ["The", "identification", "of", "C2699116#ent", "<e1>", "that", "the", "C1425218#ent", "<e2>", "beyond", "neuronal", "tissue", "that", "roundabout/slit", "interactions", "are", "likely", "to", "have", "a", "role", "in", "angiogenesis", "."], "h": {"id": "C2699116", "name": "C2699116#ent", "pos": [3, 4]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1425218", "name": "C1425218#ent", "pos": [7, 8]}}
{"token": ["Interactions", "between", "C1424742#ent", "<e1>", "and", "P8", "in", "the", "absence", "of", "C1425194#ent", "<e2>", "or", "interactions", "between", "P10", "and", "P8", "in", "the", "absence", "of", "C1424742#ent", "<e1>", "could", "not", "be", "detected", "."], "h": {"id": "C1424742", "name": "C1424742#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1425194", "name": "C1425194#ent", "pos": [10, 11]}}
{"token": ["Both", "C1442864#ent", "<e1>", "DN", ")", "and", "nondiabetic", "nephropathy", "C1417614#ent", "<e2>", ")", "are", "reported", "to", "occur", "in", "patients", "with", "type", "2", "diabetes", "mellitus", "DM", ")", "."], "h": {"id": "C1442864", "name": "C1442864#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417614", "name": "C1417614#ent", "pos": [8, 9]}}
{"token": ["ADH", "transgene", "prevented", "aging-induced", "reduction", "in", "SERCA2a", "and", "C1415651#ent", "<e1>", "without", "affecting", "up-regulated", "C1418650#ent", "<e2>", "."], "h": {"id": "C1415651", "name": "C1415651#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418650", "name": "C1418650#ent", "pos": [13, 14]}}
{"token": ["Using", "size", "exclusion", "chromatography", "co-immunoprecipitation", ",", "we", "demonstrate", "that", "the", "C1705325#ent", "<e1>", "recruited", "into", "a", "scaffolding", "complex", "C0812264#ent", "<e2>", "and", "beta-arrestins", "."], "h": {"id": "C1705325", "name": "C1705325#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812264", "name": "C0812264#ent", "pos": [17, 18]}}
{"token": ["Restoration", "of", "enzyme", "activity", "specific", "to", "the", "C1565919#ent", "<e1>", "isozyme", ",", "but", "not", "to", "the", "C1420369#ent", "<e2>", ",", "beta2", ",", "delta", "or", "gamma", "forms"], "h": {"id": "C1565919", "name": "C1565919#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420369", "name": "C1420369#ent", "pos": [15, 16]}}
{"token": ["Several", "parasitic", "infections", "fasciolosis", ",", "toxocariosis", "or", "C0003950#ent", "<e1>", "are", "important", "C0043528#ent", "<e2>", "."], "h": {"id": "C0003950", "name": "C0003950#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0043528", "name": "C0043528#ent", "pos": [11, 12]}}
{"token": ["C0023530#ent", "<e1>", "is", "an", "almost", "constant", "feature", "of", "C0007965#ent", "<e2>", "CHS", ")", "."], "h": {"id": "C0023530", "name": "C0023530#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C0007965", "name": "C0007965#ent", "pos": [8, 9]}}
{"token": ["A", "dose-dependent", "inhibition", "of", "C0011486#ent", "<e1>", "was", "observed", ",", "highlighting", "this", "C0031727#ent", "<e2>", "as", "a", "possible", "additional", "secondary", "molecular", "target", "imatinib", "."], "h": {"id": "C0011486", "name": "C0011486#ent", "pos": [4, 5]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [11, 12]}}
{"token": ["The", "C0108554#ent", "<e1>", "associated", "with", "microsomal", "fraction", "enriched", "in", "markers", "for", "plasma", "membrane", "C1423498#ent", "<e2>", "(", "5'-nucleotidase", "and", "galactosyltransferase", "respectively", ")", "."], "h": {"id": "C0108554", "name": "C0108554#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1423498", "name": "C1423498#ent", "pos": [13, 14]}}
{"token": ["Fifteen", "patients", "with", "osteogenic", "sarcoma", "high-dose", "methotrexate", "chemotherapy", "studied", "in", "a", "randomized", ",", "double-blind", ",", "placebo-controlled", "trial", "oral", "and", "smoked", "delta-9-tetrahydrocannabinol", "(", "C1705616#ent", "<e1>", ")", "as", "an", "C0003297#ent", "<e2>", "."], "h": {"id": "C1705616", "name": "C1705616#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0003297", "name": "C0003297#ent", "pos": [27, 28]}}
{"token": ["Bacteriophage", "lambda", "protein", "phosphatase", "lambdaPP", ")", "is", "a", "member", "of", "a", "large", "superfamily", "of", "metallophosphoesterases", ",", "including", "serine/threonine", "protein", "phosphatases", "purple", "acid", "phosphatases", "5'-nucleotidase", ",", "and", "DNA", "repair", "C0014442#ent", "<e1>", "such", "as", "C3273855#ent", "<e2>", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [28, 29]}, "relation": "NA", "t": {"id": "C3273855", "name": "C3273855#ent", "pos": [32, 33]}}
{"token": ["Together", "with", "the", "C0056909#ent", "<e1>", "abundance", "differences", ",", "we", "conclude", "that", "C0211705#ent", "<e2>", "and/or", "phosphatase", "activity", "different", "in", "CT", "and", "HPL", "."], "h": {"id": "C0056909", "name": "C0056909#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [11, 12]}}
{"token": ["Distribution", "of", "two", "C3541394#ent", "<e1>", "involved", "in", "the", "ectonucleotidase", "enzyme", "chain", "C1414412#ent", "<e2>", "NTPDase1", ")", "and", "ecto-5'-nucleotidase", ",", "was", "assessed", "by", "immunohistochemistry", "in", "the", "rat", "hippocampus", "."], "h": {"id": "C3541394", "name": "C3541394#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414412", "name": "C1414412#ent", "pos": [11, 12]}}
{"token": ["The", "authors", "present", "the", "case-history", "of", "a", "83-year-old", "patient", "hospitalized", "operated", "on", "account", "of", "C4019039#ent", "<e1>", "caused", "by", "C1112565#ent", "<e2>"], "h": {"id": "C4019039", "name": "C4019039#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1112565", "name": "C1112565#ent", "pos": [18, 19]}}
{"token": ["Analyses", "of", "lung", "lavage", "BAL", ")", "C0225326#ent", "<e1>", "content", "early", "in", "the", "disease", "showed", "that", ",", "despite", "identical", "injected", "doses", "the", "subset", "of", "sheep", "with", "C0206062#ent", "<e2>", "significantly", "more", "C0225326#ent", "<e1>", "retention", "."], "h": {"id": "C0206062", "name": "C0206062#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [6, 7]}}
{"token": ["Interestingly", ",", "the", "expression", "of", "C0387583#ent", "<e1>", "was", "not", "inhibited", "at", "1mM", "C0007804#ent", "<e2>", ",", "but", "was", "even", "enhanced", "significantly", "."], "h": {"id": "C0387583", "name": "C0387583#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0007804", "name": "C0007804#ent", "pos": [12, 13]}}
{"token": ["The", "pathways", "are", "those", "of", "C0151317#ent", "<e1>", "and", "several", "studies", "have", "revealed", "a", "relationship", "between", "arterial", "lesions", "C0004610#ent", "<e2>"], "h": {"id": "C0151317", "name": "C0151317#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004610", "name": "C0004610#ent", "pos": [17, 18]}}
{"token": ["The", "C0079429#ent", "<e1>", "is", "maternally", "imprinted", "is", "linked", "to", "developmental", "disorders", "as", "growth", "retardation", "transient", "C1833104#ent", "<e2>", "TNDM", ")", "."], "h": {"id": "C0079429", "name": "C0079429#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1833104", "name": "C1833104#ent", "pos": [15, 16]}}
{"token": ["The", "similarity", "between", "C3540480#ent", "<e1>", "and", "C1415638#ent", "<e2>", "suggests", "that", "C3540480#ent", "<e1>", "could", "be", "re-named", "AUF2", "."], "h": {"id": "C1415638", "name": "C1415638#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3540480", "name": "C3540480#ent", "pos": [3, 4]}}
{"token": ["Recombinants", "with", "the", "C1512488#ent", "<e1>", "L", ")", "chains", "were", "prepared", "to", "yield", "C0299505#ent", "<e2>", "molecules", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0299505", "name": "C0299505#ent", "pos": [12, 13]}}
{"token": ["The", "immediate", "and", "late", "results", "Weinberg", "'s", "operation", "have", "been", "studied", "in", "56", "patients", "with", "C0264694#ent", "<e1>", "CIHD", ")", "with", "C0007795#ent", "<e2>"], "h": {"id": "C0264694", "name": "C0264694#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0007795", "name": "C0007795#ent", "pos": [20, 21]}}
{"token": ["The", "density", "of", "serotonin", "positive", "C0042345#ent", "<e1>", "increased", "slightly", "by", "C1422587#ent", "<e2>", ",", "whereas", "substance", "P", "enkephalin", "positive", "fibers", "increased", "considerably", "by", "this", "age", "."], "h": {"id": "C0042345", "name": "C0042345#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1422587", "name": "C1422587#ent", "pos": [10, 11]}}
{"token": ["As", "expected", ",", "GC", "inhibited", "the", "expression", "of", "molecules", "responsible", "for", "inflammation", "such", "as", "cytokines", "(", "IFNbeta", "and", "C1332791#ent", "<e1>", ")", "and", "chemokines", "(", "RANTES", "and", "C1705592#ent", "<e2>", ")", "."], "h": {"id": "C1332791", "name": "C1332791#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1705592", "name": "C1705592#ent", "pos": [26, 27]}}
{"token": ["The", "effects", "of", "baclofen", "and", "C0030311#ent", "<e1>", "evoked", "electromyogram", "EMG", ")", ",", "cortical", "electroencephalogram", "EEG", ")", "and", "auditory", "brainstem", "responses", "C1412101#ent", "<e2>", ")", "were", "studied", "in", "pentobarbital", "anesthetized", "normal", "rabbits", "."], "h": {"id": "C0030311", "name": "C0030311#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1412101", "name": "C1412101#ent", "pos": [20, 21]}}
{"token": ["In", "this", "experimental", "study", "we", "measured", "the", "force", "needed", "to", "puncture", "the", "C0023899#ent", "<e1>", "(", "low", "elastin", "and", "the", "spleen", "(", "C0013765#ent", "<e2>", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0013765", "name": "C0013765#ent", "pos": [21, 22]}}
{"token": ["Extrapyramidal", "symptoms", "present", "clinically", "as", "acute", "dystonic", "reactions", ",", "tardive", "dyskinesia", "C1276035#ent", "<e1>", ",", "Parkinsonism", ",", "akathisia", ",", "and", "C0027849#ent", "<e2>"], "h": {"id": "C1276035", "name": "C1276035#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0027849", "name": "C0027849#ent", "pos": [19, 20]}}
{"token": ["In", "concert", "with", "the", "activation", "of", "C0084340#ent", "<e1>", "by", "C0812252#ent", "<e2>", ",", "C0812252#ent", "<e2>", "was", "found", "to", "associate", "with", "Rho-GDI", ",", "which", "has", "been", "shown", "to", "bind", "to", "ERMs", "."], "h": {"id": "C0084340", "name": "C0084340#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [9, 10]}}
{"token": ["BAY", "41", "-", "2272", "is", "a", "novel", "direct", "C1422492#ent", "<e1>", "of", "soluble", "guanylate", "cyclase", "but", "whether", "this", "C0013227#ent", "<e2>", "may", "be", "an", "effective", "therapy", "for", "PPHN", "is", "unknown", "."], "h": {"id": "C1422492", "name": "C1422492#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [17, 18]}}
{"token": ["Together", ",", "these", "findings", "suggest", "that", "C1704803#ent", "<e1>", "is", "a", "novel", "component", "of", "a", "RAS-dependent", "signaling", "pathway", "regulates", "C1706586#ent", "<e2>", "function", "and/or", "targets", "C1706586#ent", "<e2>", "to", "a", "specific", "subcellular", "compartment", "RAS", "activation", "."], "h": {"id": "C1704803", "name": "C1704803#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706586", "name": "C1706586#ent", "pos": [18, 19]}}
{"token": ["The", "elevated", "renal", "excretion", "C0675175#ent", "<e1>", "decreased", "after", "biliary", "drainage", "patients", "with", "C0022346#ent", "<e2>"], "h": {"id": "C0675175", "name": "C0675175#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0022346", "name": "C0022346#ent", "pos": [12, 13]}}
{"token": ["Monoclonal", "antibody", "C1423586#ent", "<e1>", "and", "MHV-A59", "virions", "bound", "only", "to", "C0034861#ent", "<e2>", "the", "entire", "first", "domain", "of", "MHV", "receptor", "."], "h": {"id": "C1423586", "name": "C1423586#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034861", "name": "C0034861#ent", "pos": [10, 11]}}
{"token": ["Retrospective", "growth", "data", "were", "evaluated", "for", "82", "C0004096#ent", "<e1>", "children", "(", "59", "%", "dependent", "on", "oral", "corticosteroids", "receiving", "C0040866#ent", "<e2>", "aerosol", "for", "1", "year", "."], "h": {"id": "C0004096", "name": "C0004096#ent", "pos": [7, 8]}, "relation": "may_be_prevented_by", "t": {"id": "C0040866", "name": "C0040866#ent", "pos": [18, 19]}}
{"token": ["Sowda", "is", "a", "form", "of", "C0029002#ent", "<e1>", "in", "Yemen", "characterized", "by", "unilateral", "dermatitis", "one", "C0030196#ent", "<e2>", ",", "with", "enlargement", "of", "the", "regional", "lymph", "nodes"], "h": {"id": "C0029002", "name": "C0029002#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0030196", "name": "C0030196#ent", "pos": [14, 15]}}
{"token": ["Hemodynamic", "and", "antiarrhythmic", "effects", "of", "and", "C0057941#ent", "<e1>", "were", "examined", "in", "51", "patients", "with", "premature", "ventricular", "contraction", "with", "neurocirculatory", "dystonia", "C1956346#ent", "<e2>"], "h": {"id": "C0057941", "name": "C0057941#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [20, 21]}}
{"token": ["The", "p66", "subunit", "both", "a", "C1335440#ent", "<e1>", "and", "an", "C0085431#ent", "<e2>", "proteolytic", "cleavage", "p66", "removes", "the", "C0085431#ent", "<e2>", "yield", "the", "p51", "subunit", "."], "h": {"id": "C1335440", "name": "C1335440#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0085431", "name": "C0085431#ent", "pos": [9, 10]}}
{"token": ["Besides", "the", "three", "known", "genes", "(", "RHO", ",", "RDS/Peripherin", ",", "NRL", ")", "involved", "in", "autosomal", "dominant", "retinitis", "pigmentosa", "C1412234#ent", "<e1>", ")", ",", "a", "fourth", "gene", ",", "C1417030#ent", "<e2>", ",", "has", "been", "recently", "identified", "."], "h": {"id": "C1412234", "name": "C1412234#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1417030", "name": "C1417030#ent", "pos": [26, 27]}}
{"token": ["APO", "eliminated", "PPI", "for", "a", "C4284306#ent", "<e1>", "reduced", "PPI", "for", "a", "brighter", "flash", "to", "a", "level", "normally", "obtained", "with", "the", "C4284306#ent", "<e1>", "while", "increasing", "both", "C1332675#ent", "<e1>", "control", "values", "and", "activity", "."], "h": {"id": "C4284306", "name": "C4284306#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332675", "name": "C1332675#ent", "pos": [25, 26]}}
{"token": ["Sulphatiazole", "was", "more", "acetylated", "(", "16.2", "per", "cent", ")", "than", "C0037134#ent", "<e1>", "(", "7.0", "per", "cent", ")", "or", "C0038684#ent", "<e2>", "(", "8.4", "per", "cent", ")", "."], "h": {"id": "C0037134", "name": "C0037134#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0038684", "name": "C0038684#ent", "pos": [18, 19]}}
{"token": ["The", "C0950121#ent", "<e1>", "characterised", "by", "the", "triad", ":", "progressive", "nephropathy", "due", "to", "C0268747#ent", "<e2>", "male", "pseudo-hermaphroditism", "(", "XY", "karyotype", "ambiguous", "or", "female", "genital", "organs", "and", "an", "increased", "risk", "of", "developing", "Wilms'", "tumour", "gonadoblastoma", "."], "h": {"id": "C0950121", "name": "C0950121#ent", "pos": [1, 2]}, "relation": "has_manifestation", "t": {"id": "C0268747", "name": "C0268747#ent", "pos": [12, 13]}}
{"token": ["With", "long", "duplex", "substrates", "(", ">", "500", "base", "pairs", ")", ",", "the", "presence", "of", "a", "fork", "substantially", "stimulated", "the", "C0610268#ent", "<e1>", "activity", "in", "the", "presence", "of", "E.", "coli", "C1420423#ent", "<e2>", "."], "h": {"id": "C0610268", "name": "C0610268#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [28, 29]}}
{"token": ["There", "was", "no", "significant", "relationship", "between", "either", "of", "the", "C0812204#ent", "<e1>", "isoforms", "and", "cathepsin", "D", "C3811130#ent", "<e2>", ")", ",", "urokinase", "plasminogen", "activator", "uPA", ")", ",", "its", "inhibitor", "(", "PAI-1", ")", ",", "steroid", "hormone", "receptors", "ploidy", "status", "."], "h": {"id": "C0812204", "name": "C0812204#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3811130", "name": "C3811130#ent", "pos": [15, 16]}}
{"token": ["Deletion", "of", "C3813546#ent", "<e1>", ",", "like", "depletion", "of", "RSC", "C0599220#ent", "<e2>", "Moreira", ",", "J.M.", ",", "Holmberg", ",", "S.", ",", "1999", "."], "h": {"id": "C3813546", "name": "C3813546#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0599220", "name": "C0599220#ent", "pos": [9, 10]}}
{"token": ["The", "virulence", "factors", "E.", "coli", "C0748023#ent", "<e1>", "studied", "using", "59", "E.", "coli", "isolated", "from", "uncomplicated", "C0033581#ent", "<e2>", "."], "h": {"id": "C0748023", "name": "C0748023#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [15, 16]}}
{"token": ["Up", "to", "the", "present", ",", "only", "one", "pedigree", "with", "autosomal", "dominant", "C1851920#ent", "<e1>", "linked", "to", "the", "C4284735#ent", "<e2>", "been", "reported", "."], "h": {"id": "C1851920", "name": "C1851920#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4284735", "name": "C4284735#ent", "pos": [16, 17]}}
{"token": ["However", ",", "when", "wild-type", "and", "C1704866#ent", "<e1>", "knockout", "mice", "subjected", "to", "C1510471#ent", "<e2>", "gestation", ",", "the", "survival", "rate", "birth", "was", "3.3-fold", "lower", "for", "C1704866#ent", "<e1>", "knockout", "mice"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704866", "name": "C1704866#ent", "pos": [5, 6]}}
{"token": ["In", "nearly", "all", "of", "these", "areas", ",", "however", ",", "C0023343#ent", "<e1>", "remains", "poorly", "understood", "compared", "to", "other", "major", "C0004623#ent", "<e2>"], "h": {"id": "C0023343", "name": "C0023343#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0004623", "name": "C0004623#ent", "pos": [18, 19]}}
{"token": ["A", "C0536221#ent", "<e1>", "bio-sensing", "chip", "was", "designed", "based", "on", "the", "electrochemiluminescent", "(", "C1705075#ent", "<e2>", ")", "detection", "of", "enzymatically", "produced", "hydrogen", "peroxide"], "h": {"id": "C0536221", "name": "C0536221#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705075", "name": "C1705075#ent", "pos": [12, 13]}}
{"token": ["Prior", "and", "ongoing", "use", "of", "narcotics", "and", "C0020592#ent", "<e1>", "acts", "to", "compound", "and", "aggravate", "the", "C1298685#ent", "<e2>"], "h": {"id": "C0020592", "name": "C0020592#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1298685", "name": "C1298685#ent", "pos": [15, 16]}}
{"token": ["In", "this", "study", ",", "the", "clinical", "and", "histologic", "severity", "of", "inflammatory", "bowel", "disease", "C0021390#ent", "<e1>", ")", "was", "determined", "in", "IL-10-/-", "mice", "treated", "orally", "with", "C0006217#ent", "<e2>", "in", "vivo"], "h": {"id": "C0021390", "name": "C0021390#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0006217", "name": "C0006217#ent", "pos": [24, 25]}}
{"token": ["In", "total", ",", "15", "patients", "in", "four", "autosomal", "dominant", "C0018790#ent", "<e1>", "families", "had", "CAG/CAA", "repeat", "expansions", "in", "the", "C1705304#ent", "<e2>", "gene", "ranging", "from", "45", "to", "54", "repeats", "."], "h": {"id": "C0018790", "name": "C0018790#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705304", "name": "C1705304#ent", "pos": [18, 19]}}
{"token": ["Before", "and", "after", "operation", ",", "the", "activities", "of", "serum", "phospholipase", "A2", "C1706169#ent", "<e1>", ")", "and", "amylase", "(", "C4284022#ent", "<e2>", ")", "were", "assayed", "and", "the", "basal", "pressures", "the", "ducts", "were", "measured", "when", "secretin", "was", "injected", "."], "h": {"id": "C1706169", "name": "C1706169#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C4284022", "name": "C4284022#ent", "pos": [17, 18]}}
{"token": ["C4020705#ent", "<e1>", "an", "uncommon", "cystic", "renal", "condition", "characterized", "by", "cystic", "dilatation", "a", "C0268731#ent", "<e2>"], "h": {"id": "C4020705", "name": "C4020705#ent", "pos": [0, 1]}, "relation": "has_nichd_parent", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [12, 13]}}
{"token": ["Treatment", "with", "nerolidol", "arrested", "development", "of", "the", "intraerythrocytic", "stages", "of", "the", "parasites", ",", "indicating", "that", "the", "C1254351#ent", "<e1>", "may", "have", "an", "C0003374#ent", "<e2>", "potential", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [16, 17]}, "relation": "nichd_parent_of", "t": {"id": "C0003374", "name": "C0003374#ent", "pos": [21, 22]}}
{"token": ["Tissue", "type", "plasminogen", "activator", "C0078956#ent", "<e1>", ")", "can", "be", "effective", "therapy", "for", "C0262469#ent", "<e2>", "restoring", "cerebral", "perfusion"], "h": {"id": "C0078956", "name": "C0078956#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0262469", "name": "C0262469#ent", "pos": [12, 13]}}
{"token": ["Antibiotics", "were", "administered", "in", "large", "doses", "customary", "intervals", "12", "to", "20", "h", "before", "total", "C1337104#ent", "<e1>", "or", "knee", "replacement", "anticipated", "levels", "of", "each", "C1254351#ent", "<e2>", "were", "achieved", "in", "the", "serum", "."], "h": {"id": "C1337104", "name": "C1337104#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1254351", "name": "C1254351#ent", "pos": [23, 24]}}
{"token": ["Analytical", "figures", "of", "merit", "are", "presented", "for", "C0007028#ent", "<e1>", "human", "serum", "albumin", "gamma-globulins", ",", "and", "C0039815#ent", "<e2>", "."], "h": {"id": "C0007028", "name": "C0007028#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039815", "name": "C0039815#ent", "pos": [15, 16]}}
{"token": ["This", "study", "provides", "evidence", "that", "C4086533#ent", "<e1>", ",", "a", "key", "metabolite", "accumulating", "in", "maple", "syrup", "C0012634#ent", "<e2>", "increases", "phosphorylation", "of", "IF", "proteins"], "h": {"id": "C4086533", "name": "C4086533#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [15, 16]}}
{"token": ["The", "mean", "serum", "creatinine", "concentration", "in", "these", "four", "patients", "fell", "from", "9.7", "to", "2.9", "mg/dL.", "Thus", ",", "impressive", "renal", "functional", "improvement", "may", "occur", "with", "C0026196#ent", "<e1>", "use", "in", "some", "patients", "with", "C0020540#ent", "<e2>"], "h": {"id": "C0026196", "name": "C0026196#ent", "pos": [24, 25]}, "relation": "may_treat", "t": {"id": "C0020540", "name": "C0020540#ent", "pos": [31, 32]}}
{"token": ["Purified", "C1426677#ent", "<e1>", "were", "retrieved", "by", "bronchoalveolar", "lavage", "11", "C0077025#ent", "<e2>", "patients", "and", "10", "normal", "subjects", "and", "were", "cultured", "with", "or", "without", "the", "NO", "inhibitor", "N(G)-monomethyl-L-arginine", "L-NMMA", ")", "."], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0077025", "name": "C0077025#ent", "pos": [9, 10]}}
{"token": ["Mitochondrial", "DNA", "depletion", "seen", "in", "C1850406#ent", "<e1>", "in", "respiratory", "chain", "disorders", "infancy", "was", "associated", "with", "C0008370#ent", "<e2>", "and", "cirrhosis", "in", "the", "former", "and", "microvesicular", "steatosis", "oncocytic", "transformation", "mitochondrial", "hyperplasia", "in", "the", "latter", "."], "h": {"id": "C1850406", "name": "C1850406#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0008370", "name": "C0008370#ent", "pos": [15, 16]}}
{"token": ["Mannitol", "and", "C0067726#ent", "<e1>", "were", "accumulated", "when", "C1161331#ent", "<e2>", "instead", "of", "salts", "was", "used", "to", "reduce", "the", "medium", "water", "activity"], "h": {"id": "C0067726", "name": "C0067726#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [7, 8]}}
{"token": ["An", "C0051510#ent", "<e1>", "target", "apparently", "resides", "on", "the", "C3811116#ent", "<e2>"], "h": {"id": "C0051510", "name": "C0051510#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3811116", "name": "C3811116#ent", "pos": [8, 9]}}
{"token": ["Cholesterol-lowering", "statins", "C0004153#ent", "<e1>", "and", "plasma", "C3540823#ent", "<e2>", "levels", "."], "h": {"id": "C0004153", "name": "C0004153#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540823", "name": "C3540823#ent", "pos": [6, 7]}}
{"token": ["C0022575#ent", "<e1>", "KCS", ")", ",", "more", "commonly", "known", "as", "C0013238#ent", "<e2>", "is", "an", "inflammatory", "condition", "the", "ocular", "surface", "caused", "by", "a", "pathologic", "reduction", "the", "aqueous", "component", "of", "the", "tear", "film", "."], "h": {"id": "C0022575", "name": "C0022575#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0013238", "name": "C0013238#ent", "pos": [9, 10]}}
{"token": ["Thus", ",", "the", "int", "function", "P2", "is", "expressed", "C0907533#ent", "<e1>", "by", "the", "C0038826#ent", "<e2>", "but", "is", "not", "expressed", "by", "the", "prophage", "even", "in", "the", "absence", "of", "phage", "repressor"], "h": {"id": "C0907533", "name": "C0907533#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0038826", "name": "C0038826#ent", "pos": [12, 13]}}
{"token": ["C0023523#ent", "<e1>", "may", "be", "confused", "with", "leukoplakia", ",", "Darier's", "disease", "C1721005#ent", "<e2>", "pachyonychia", "congenita", "or", "candidal", "infection"], "h": {"id": "C0023523", "name": "C0023523#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1721005", "name": "C1721005#ent", "pos": [10, 11]}}
{"token": ["The", "activity", "of", "the", "C0003589#ent", "<e1>", "could", "be", "restored", "with", "Ca2", "+", ",", "Zn2+", "C1417500#ent", "<e2>", "+", ",", "and", "Co2+"], "h": {"id": "C0003589", "name": "C0003589#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417500", "name": "C1417500#ent", "pos": [14, 15]}}
{"token": ["Cells", "deleted", "for", "Brca2", "exon", "27", "hypersensitive", "to", "gamma-radiation", ",", "streptonigrin", ",", "C0026254#ent", "<e1>", "camptothecin", "and", "mildly", "resistant", "to", "C0123145#ent", "<e2>", "which", "is", "similar", "to", "HR", "defective", "cells", "null", "for", "Rad54", "."], "h": {"id": "C0026254", "name": "C0026254#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0123145", "name": "C0123145#ent", "pos": [19, 20]}}
{"token": ["Analysis", "of", "a", "human", "pituitary", "adenoma", "cell", "line", "immortalized", "by", "recombinant", "defective", "adenovirus", "(", "HP75", ")", ",", "which", "expressed", "chromogranin", "A", "FSH", ",", "C1414407#ent", "<e1>", "and", "PC2", "showed", "that", "C3813590#ent", "<e2>", "was", "secreted", "by", "these", "immortalized", "cells"], "h": {"id": "C1414407", "name": "C1414407#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C3813590", "name": "C3813590#ent", "pos": [29, 30]}}
{"token": ["Recent", "clinical", "trials", "shown", "a", "beneficial", "effect", "of", "mizoribine", "(", "C1538642#ent", "<e1>", ")", ",", "an", "immunosuppressive", "drug", "in", "the", "treatment", "of", "new-onset", "C0017661#ent", "<e2>", "IgAN", ")", "."], "h": {"id": "C1538642", "name": "C1538642#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0017661", "name": "C0017661#ent", "pos": [22, 23]}}
{"token": ["This", "study", "was", "conducted", "to", "assess", "C0008370#ent", "<e1>", "in", "human", "C0015652#ent", "<e2>", "."], "h": {"id": "C0008370", "name": "C0008370#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0015652", "name": "C0015652#ent", "pos": [10, 11]}}
{"token": ["Glucocorticoids", "inhibit", "basal", "and", "C0031644#ent", "<e1>", "PEPCK", ")", "gene", "transcription", "adipocytes", "whereas", "beta-adrenergic", "agonists", "C3540783#ent", "<e2>", "are", "stimulatory", "."], "h": {"id": "C0031644", "name": "C0031644#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3540783", "name": "C3540783#ent", "pos": [14, 15]}}
{"token": ["Finally", ",", "while", "no", "C0339573#ent", "<e1>", "subjects", "had", "localized", "sensitivity", "loss", "for", "C0085635#ent", "<e2>", "the", "horizontal", "nasal", "retina", "four", "did", "show", "local", "field", "defects", "blue", "test", "TRUNCATED", "AT", "250", "WORDS", ")"], "h": {"id": "C0339573", "name": "C0339573#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0085635", "name": "C0085635#ent", "pos": [12, 13]}}
{"token": ["The", "nature", "and", "treatment", "of", "the", "three", "major", "types", "of", "C3495559#ent", "<e1>", "systemic", ",", "polyarticular", ",", "and", "C3898105#ent", "<e2>", "--", "are", "presented", "."], "h": {"id": "C3495559", "name": "C3495559#ent", "pos": [10, 11]}, "relation": "nichd_parent_of", "t": {"id": "C3898105", "name": "C3898105#ent", "pos": [17, 18]}}
{"token": ["The", "C2002622#ent", "<e1>", "a", "gamma-carboxylation", "recognition", "site", "in", "the", "C0030956#ent", "<e2>", ",", "between", "the", "signal", "peptide", "the", "mature", "protein", "that", "directs", "gamma-carboxylation", "of", "specific", "glutamic", "acid", "residues"], "h": {"id": "C2002622", "name": "C2002622#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0030956", "name": "C0030956#ent", "pos": [9, 10]}}
{"token": ["Studies", "using", "recombinant", "P450s", "suggested", "that", "the", "major", "P450", "isozymes", "in", "the", "bioactivation", "of", "C0016384#ent", "<e1>", "and", "its", "metabolites", "were", "C1620185#ent", "<e2>", ",", "CYP3A4", ",", "and", "CYP2C19", "."], "h": {"id": "C0016384", "name": "C0016384#ent", "pos": [14, 15]}, "relation": "chemical_or_drug_is_metabolized_by_enzyme", "t": {"id": "C1620185", "name": "C1620185#ent", "pos": [20, 21]}}
{"token": ["In", "this", "pulse-chase", "study", ",", "rainbow", "trout", "C0342895#ent", "<e1>", "a", "diet", "containing", "deuterated", "(", "D5", ")", "(17,17,18,18,18)-18:3n-3", "C0005059#ent", "<e2>", "D5", "-", "22:6n-3", "in", "pyloric", "ceca", "a", "greater", "extent", "than", "in", "liver", "2", "d", "."], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0005059", "name": "C0005059#ent", "pos": [17, 18]}}
{"token": ["The", "C1414998#ent", "<e1>", "located", "in", "a", "gene-rich", "region", "1q21", "that", "contains", "six", "C1417679#ent", "<e2>", "and", "two", "pseudogenes", "within", "75", "kb", "."], "h": {"id": "C1414998", "name": "C1414998#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [12, 13]}}
{"token": ["Low-dose", "C1880082#ent", "<e1>", "1", ",", "3", "and", "6", "mg", ")", "is", "a", "C0003290#ent", "<e2>", "being", "investigated", "for", "the", "treatment", "of", "primary", "insomnia", "in", "adult", "and", "geriatric", "patients", "."], "h": {"id": "C1880082", "name": "C1880082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0003290", "name": "C0003290#ent", "pos": [12, 13]}}
{"token": ["However", ",", "content", "and", "total", "activity", "C1334539#ent", "<e1>", "MLCK", ")", "and", "content", "of", "caldesmon", "(", "C1956346#ent", "<e2>", ")", "were", "three-", "to", "fourfold", "higher", "in", "EB", "than", "in", "LES", "."], "h": {"id": "C1334539", "name": "C1334539#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1956346", "name": "C1956346#ent", "pos": [15, 16]}}
{"token": ["We", "have", "previously", "cloned", "a", "novel", "guanine", "nucleotide-binding", "protein", "(G-protein)-coupled", "receptor", ",", "C1414257#ent", "<e1>", ",", "that", "has", "sequence", "similarity", "a", "C1414254#ent", "<e2>", "edg2", "."], "h": {"id": "C1414257", "name": "C1414257#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1414254", "name": "C1414254#ent", "pos": [20, 21]}}
{"token": ["In", "conclusion", ",", "the", "C0035460#ent", "<e1>", "increases", "the", "systemic", "absorption", "nasally", "administered", "C0027235#ent", "<e2>", "but", "the", "small", "increase", "in", "the", "absorption", "is", "not", "likely", "to", "have", "any", "clinical", "consequences"], "h": {"id": "C0035460", "name": "C0035460#ent", "pos": [4, 5]}, "relation": "may_be_treated_by", "t": {"id": "C0027235", "name": "C0027235#ent", "pos": [12, 13]}}
{"token": ["In", "three", "cases", ",", "an", "C1412821#ent", "<e1>", "homologue", "to", "the", "transcription", "regulator", "protein", "C1427242#ent", "<e2>", ")", "of", "the", "pheBA", "operon", "was", "determined", "."], "h": {"id": "C1412821", "name": "C1412821#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1427242", "name": "C1427242#ent", "pos": [13, 14]}}
{"token": ["These", "data", "suggest", "that", "beta-adrenergic", "receptor", "stimulation", "of", "vascular", "L-type", "Ca2", "+", "channels", "involves", "both", "C0002328#ent", "<e1>", "and", "betagamma", "G-protein", "subunits", "which", "exert", "their", "effects", "through", "PKA", "and", "C1826724#ent", "<e2>", ",", "respectively", "."], "h": {"id": "C0002328", "name": "C0002328#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1826724", "name": "C1826724#ent", "pos": [28, 29]}}
{"token": ["Based", "on", "Southern", "blotting", "analysis", "a", "single", "C1705766#ent", "<e1>", "gene", "gives", "rise", "to", "the", "C1420295#ent", "<e2>", "patterns", "of", "C1705766#ent", "<e1>", "mRNA", "expression", "."], "h": {"id": "C1705766", "name": "C1705766#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [14, 15]}}
{"token": ["In", "vitro", "activity", "assay", "that", "TNF-alpha", "increased", "the", "dithiothreitol", "(DTT)-resistant", "C0031667#ent", "<e1>", "activity", "which", "was", "blocked", "by", "the", "C1333201#ent", "<e2>", "AACOCF3", "."], "h": {"id": "C0031667", "name": "C0031667#ent", "pos": [10, 11]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C1333201", "name": "C1333201#ent", "pos": [18, 19]}}
{"token": ["We", "have", "investigated", "the", "effects", "of", "flavopiridol", ",", "a", "novel", "C0243459#ent", "<e1>", "is", "selective", "for", "C0243045#ent", "<e2>", "on", "hypoxia-induced", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "expression", "in", "human", "monocytes", "."], "h": {"id": "C0243459", "name": "C0243459#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0243045", "name": "C0243045#ent", "pos": [15, 16]}}
{"token": ["A", "C1368803#ent", "<e1>", "mutant", "lacking", "C4284622#ent", "<e2>", "and", "unable", "to", "bind", "filamin-A", "failed", "to", "induce", "the", "multinucleated", "phenotype", "."], "h": {"id": "C1368803", "name": "C1368803#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C4284622", "name": "C4284622#ent", "pos": [5, 6]}}
{"token": ["Although", "TMG", "could", "not", "degrade", "pullulan", ",", "it", "rapidly", "hydrolyzes", "C0050393#ent", "<e1>", ",", "a", "strong", "amylase", "and", "glucosidase", "inhibitor", "to", "C0171151#ent", "<e2>", "and", "glucose", "."], "h": {"id": "C0050393", "name": "C0050393#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0171151", "name": "C0171151#ent", "pos": [20, 21]}}
{"token": ["The", "role", "of", "thromboxane", "was", "investigated", "with", "an", "inhibitor", "of", "C0040060#ent", "<e1>", "Dazoxiben", ")", "and", "with", "a", "C1516869#ent", "<e2>", "13-APT", ")", "."], "h": {"id": "C0040060", "name": "C0040060#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1516869", "name": "C1516869#ent", "pos": [17, 18]}}
{"token": ["Older", "products", "eg", ",", "isoproterenol", "and", "C0022176#ent", "<e1>", ")", "contain", "enough", "sulfites", "to", "produce", "C0006266#ent", "<e2>", "in", "most", "patients", "with", "asthma", ",", "even", "in", "those", "without", "a", "prior", "history", "of", "sulfite", "sensitivity", "."], "h": {"id": "C0022176", "name": "C0022176#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0006266", "name": "C0006266#ent", "pos": [14, 15]}}
{"token": ["In", "fibroblasts", ",", "Shroom", "readily", "associates", "with", "actin", "stress", "fibers", "induces", "bundling", ",", "C3889722#ent", "<e1>", "is", "found", "on", "cortical", "actin", "and", "C1822722#ent", "<e2>", "is", "localized", "to", "a", "cytoplasmic", "population", "F-actin", "."], "h": {"id": "C3889722", "name": "C3889722#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1822722", "name": "C1822722#ent", "pos": [21, 22]}}
{"token": ["Peptides", "corresponding", "to", "unique", "amino", "acid", "sequences", "Yb3", "as", "well", "as", "a", "C0030956#ent", "<e1>", "from", "a", "region", "of", "homology", "with", "C2985446#ent", "<e2>", "and", "Yb2", "subunits", "were", "synthesized", "."], "h": {"id": "C0030956", "name": "C0030956#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C2985446", "name": "C2985446#ent", "pos": [20, 21]}}
{"token": ["With", "a", "possible", "relationship", "between", "DFO", "treatment", "and", "this", "fatal", "C0029118#ent", "<e1>", "caution", "should", "be", "given", "before", "using", "this", "C0013227#ent", "<e2>", "and", "the", "indications", "should", "be", "definitive", "."], "h": {"id": "C0029118", "name": "C0029118#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [19, 20]}}
{"token": ["Our", "data", "indicate", "that", "PGE(1", ")", "exerts", "a", "protective", "action", "NO", "neurotoxicity", "in", "cultured", "spinal", "neurons", "and", "suggests", "a", "therapeutic", "potential", "of", "PGE(1", ")", "against", "C0037928#ent", "<e1>", "such", "as", "C0002736#ent", "<e2>"], "h": {"id": "C0037928", "name": "C0037928#ent", "pos": [25, 26]}, "relation": "related_to", "t": {"id": "C0002736", "name": "C0002736#ent", "pos": [29, 30]}}
{"token": ["C0066535#ent", "<e1>", "treatment", "was", "associated", "with", "improvements", "in", "C1415014#ent", "<e2>", "and", "malic", "enzyme", "both", "strains", ",", "and", "in", "improvements", "in", "glycemic", "parameters", "in", "obese", "rats", "."], "h": {"id": "C0066535", "name": "C0066535#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415014", "name": "C1415014#ent", "pos": [8, 9]}}
{"token": ["Myelin-associated", "glycoprotein", "MAG", ")", "and", "C1420266#ent", "<e1>", "(", "Sn", ")", "bind", "to", "sialylated", "C0032594#ent", "<e2>", "on", "cell", "surfaces", "are", "thought", "to", "be", "involved", "in", "cell-cell", "interactions"], "h": {"id": "C1420266", "name": "C1420266#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0032594", "name": "C0032594#ent", "pos": [13, 14]}}
{"token": ["C0059438#ent", "<e1>", "decreased", "the", "mRNA", "expression", "of", "C0251211#ent", "<e2>", "H4IIE", "cells", "as", "well", "as", "in", "liver", "and", "adipose", "tissue", "db/db", "mice"], "h": {"id": "C0059438", "name": "C0059438#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0251211", "name": "C0251211#ent", "pos": [7, 8]}}
{"token": ["Whereas", "panic", "disorder", "C1956346#ent", "<e1>", "coexist", "in", "patients", "with", "C0008031#ent", "<e2>", "there", "appears", "to", "be", "a", "very", "high", "prevalence", "of", "panic", "disorder", "patients", "in", "whom", "cardiac", "disease", "been", "excluded", "."], "h": {"id": "C1956346", "name": "C1956346#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0008031", "name": "C0008031#ent", "pos": [9, 10]}}
{"token": ["K562", "cells", "not", "induced", "into", "a", "responsive", "state", "to", "C1416933#ent", "<e1>", ",", "TF", ",", "or", "C1826618#ent", "<e2>", "by", "HuIFN", "gamma", "."], "h": {"id": "C1416933", "name": "C1416933#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1826618", "name": "C1826618#ent", "pos": [15, 16]}}
{"token": ["Neonatal", "C0006111#ent", "<e1>", "of", "a", "wide", "chapter", "including", "brain", "malformations", "hypoxic-ischemic", "encephalopathy", "intracranial", "infections", "perinatal", "trauma", "C0085584#ent", "<e2>"], "h": {"id": "C0006111", "name": "C0006111#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0085584", "name": "C0085584#ent", "pos": [16, 17]}}
{"token": ["In", "this", "study", "we", "assessed", "whether", "polymorphisms", "in", "the", "promoter", "region", "Fas", "and", "FasL", "and", "sFas", "and", "C1539478#ent", "<e1>", "are", "related", "to", "C4083008#ent", "<e2>", "or", "its", "distinct", "clinical", "or", "serological", "subgroups", "."], "h": {"id": "C1539478", "name": "C1539478#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C4083008", "name": "C4083008#ent", "pos": [22, 23]}}
{"token": ["C0011501#ent", "<e1>", "and", "IAA", "reduced", "the", "rate", "of", "reuptake", "of", "C0001477#ent", "<e2>", "the", "SR", "which", "was", "accompanied", "by", "a", "15", "-", "20", "%", "decrease", "of", "SR", "C0001477#ent", "<e2>", "."], "h": {"id": "C0011501", "name": "C0011501#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [10, 11]}}
{"token": ["The", "potential", "adaptive", "value", "of", "differential", "gene", "expression", "evaluated", "for", "five", "C1417679#ent", "<e1>", "in", "two", "populations", "of", "early", "generation", "C1705391#ent", "<e2>", ")", "hybrids", "between", "the", "parental", "species", "grown", "in", "the", "H.", "deserticola", "habitat", "."], "h": {"id": "C1417679", "name": "C1417679#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705391", "name": "C1705391#ent", "pos": [19, 20]}}
{"token": ["All", "three", "C0392475#ent", "<e1>", "that", "failed", "chemotherapy", "without", "cyclosporine", "expressed", "C1704873#ent", "<e2>", "with", "p170", "."], "h": {"id": "C0392475", "name": "C0392475#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1704873", "name": "C1704873#ent", "pos": [10, 11]}}
{"token": ["Here", ",", "we", "describe", "characterization", "of", "the", "only", "human", "member", "of", "the", "Rh/T2/S", "family", "of", "C0020289#ent", "<e1>", "far", "described", ",", "named", "C1427695#ent", "<e2>", "."], "h": {"id": "C0020289", "name": "C0020289#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1427695", "name": "C1427695#ent", "pos": [21, 22]}}
{"token": ["Immunological", "mechanisms", "play", "a", "role", "in", "the", "bile", "duct", "obstruction", "observed", "in", "C0008312#ent", "<e1>", "graft-versus-host", "disease", "chronic", "liver", "transplant", "rejection", "and", "possibly", "also", "in", "primary", "sclerosing", "cholangitis", "sarcoidosis", "with", "C0268312#ent", "<e2>"], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0268312", "name": "C0268312#ent", "pos": [29, 30]}}
{"token": ["The", "bile", "acid", "pattern", "was", "distinctly", "different", "between", "extrahepatic", "cholestasis", "C0008312#ent", "<e1>", "which", "mainly", "reflects", "C0268312#ent", "<e2>"], "h": {"id": "C0008312", "name": "C0008312#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268312", "name": "C0268312#ent", "pos": [15, 16]}}
{"token": ["When", "expressed", "in", "cells", ",", "C1424242#ent", "<e1>", "binds", "to", "C1367449#ent", "<e2>", "and", "activates", "NF-kappaB.", "Furthermore", ",", "endogenous", "C1424242#ent", "<e1>", "is", "found", "associated", "with", "C1367449#ent", "<e2>", "suggesting", "that", "both", "proteins", "form", "a", "pre-existing", "signaling", "complex", "cells", "."], "h": {"id": "C1367449", "name": "C1367449#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1424242", "name": "C1424242#ent", "pos": [5, 6]}}
{"token": ["Furthermore", ",", "chromatin", "immunoprecipitation", "assay", "data", "in", "LMP1-inducible", "cells", "disclose", "that", "LMP1", "induces", "formation", "of", "a", "transcriptional", "repression", "complex", "composed", "of", "DNMT1", "and", "C0019643#ent", "<e1>", "which", "locates", "on", "C0694872#ent", "<e2>", "."], "h": {"id": "C0019643", "name": "C0019643#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0694872", "name": "C0694872#ent", "pos": [28, 29]}}
{"token": ["C1290140#ent", "<e1>", "PSGN", ")", "is", "a", "frequent", "cause", "of", "C0268733#ent", "<e2>", "children", "."], "h": {"id": "C1290140", "name": "C1290140#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0268733", "name": "C0268733#ent", "pos": [9, 10]}}
{"token": ["Sar(9", ")", ",", "Met(O(2))(11)]-SP", "and", "C0074331#ent", "<e1>", ",", "selective", "agonists", "of", "the", "C4050010#ent", "<e2>", "and", "NK3", "receptors", "respectively", ",", "failed", "to", "modify", "the", "ureteral", "tone"], "h": {"id": "C0074331", "name": "C0074331#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C4050010", "name": "C4050010#ent", "pos": [12, 13]}}
{"token": ["Co-artemether", "(", "Coartem", ",", "Riamet", ")", "is", "a", "tablet", "containing", "20", "mg", "artemether", "and", "120", "mg", "C0531104#ent", "<e1>", "for", "treatment", "of", "C0024535#ent", "<e2>", "malaria", "."], "h": {"id": "C0531104", "name": "C0531104#ent", "pos": [16, 17]}, "relation": "may_treat", "t": {"id": "C0024535", "name": "C0024535#ent", "pos": [21, 22]}}
{"token": ["HCV-associated", "manifestations", "also", "include", "porphyria", "cutanea", "tarda", "C0206139#ent", "<e1>", "nephropathies", ",", "thyreopathies", ",", "sicca", "syndrome", "C1800706#ent", "<e2>", "diabetes", ",", "chronic", "polyarthritis", "sexual", "dysfunctions", "cardiopathy/atherosclerosis", ",", "and", "psychopathological", "disorders"], "h": {"id": "C0206139", "name": "C0206139#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1800706", "name": "C1800706#ent", "pos": [15, 16]}}
{"token": ["Blood", "pH", "base", "excess", "BE", ")", ",", "lactate", "(", "C1420423#ent", "<e1>", ")", ",", "carnitine", "and", "C0007258#ent", "<e2>", "measured", "."], "h": {"id": "C1420423", "name": "C1420423#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0007258", "name": "C0007258#ent", "pos": [15, 16]}}
{"token": ["It", "was", "also", "observed", "that", "the", "expression", "of", "C2709268#ent", "<e1>", "and", "phosphorylation", "of", "C3849574#ent", "<e2>", "and", "S6K1", "was", "declined", "in", "senescent", "2BS", "."], "h": {"id": "C2709268", "name": "C2709268#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [13, 14]}}
{"token": ["A", "46-year-old", "man", "who", "was", "diagnosed", "as", "chorea-acanthocytosis", ",", "a", "subgroup", "of", "C0393576#ent", "<e1>", ",", "was", "investigated", "for", "severe", "drug", "resistant", "C0036572#ent", "<e2>", "."], "h": {"id": "C0393576", "name": "C0393576#ent", "pos": [12, 13]}, "relation": "has_manifestation", "t": {"id": "C0036572", "name": "C0036572#ent", "pos": [21, 22]}}
{"token": ["This", "novel", "nor-MDP", "analogue", "protects", "mice", "against", "the", "immunosuppressive", "effect", "C1161438#ent", "<e1>", "and", "increases", "the", "nonspecific", "resistance", "of", "mice", "against", "C0026946#ent", "<e2>"], "h": {"id": "C1161438", "name": "C1161438#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0026946", "name": "C0026946#ent", "pos": [20, 21]}}
{"token": ["Current", "antithrombotic", "agents", "anticoagulants", "(", "unfractionated", "and", "low-molecular-weight", "heparin", "and", "C0597668#ent", "<e1>", "and", "platelet", "aggregation", "inhibitors", "aspirin", ",", "ticlopidine", ",", "C0070166#ent", "<e2>", ")", "."], "h": {"id": "C0597668", "name": "C0597668#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0070166", "name": "C0070166#ent", "pos": [20, 21]}}
{"token": ["This", "116-kDa", "protein", "was", "itself", "immunoreactive", "with", "a", "polyclonal", "antiserum", "raised", "against", "C1527617#ent", "<e1>", "and", "appears", "to", "be", "a", "novel", "member", "of", "the", "C0597721#ent", "<e2>"], "h": {"id": "C1527617", "name": "C1527617#ent", "pos": [12, 13]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0597721", "name": "C0597721#ent", "pos": [23, 24]}}
{"token": ["The", "steady-state", "levels", "of", "C1705519#ent", "<e1>", "and", "C1417932#ent", "<e2>", "transcripts", "were", "positively", "correlated", "suggesting", "a", "positive", "relationship", "between", "C1705519#ent", "<e1>", "expression", "and", "the", "replication", "rate", "Hep", "G2", "cells"], "h": {"id": "C1417932", "name": "C1417932#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1705519", "name": "C1705519#ent", "pos": [4, 5]}}
{"token": ["In", "an", "open", "comparative", "study", "40", "patients", "suffering", "from", "pyoderma", ",", "combustion", "(", "1st", "and", "2nd", "degrees", ")", ",", "C0023223#ent", "<e1>", "or", "inflammatory", "white", "atrophy", "treated", "with", "topical", "preparation", "containing", "either", "C0032856#ent", "<e2>", "neomycin", "."], "h": {"id": "C0023223", "name": "C0023223#ent", "pos": [19, 20]}, "relation": "may_be_treated_by", "t": {"id": "C0032856", "name": "C0032856#ent", "pos": [31, 32]}}
{"token": ["Following", "work", "there", "was", "an", "enhanced", "response", "in", "both", "plasma", "C3887648#ent", "<e1>", "and", "adrenaline", "during", "C0030812#ent", "<e2>", "but", "only", "in", "plasma", "C3887648#ent", "<e1>", "during", "metoprolol", "treatment", "."], "h": {"id": "C3887648", "name": "C3887648#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0030812", "name": "C0030812#ent", "pos": [15, 16]}}
{"token": ["The", "BOMM", "regimen", "produced", "a", "response", "rate", "significantly", "better", "than", "C0042679#ent", "<e1>", ",", "BLM", ",", "and", "C1417487#ent", "<e2>", "combination", "(", "VBM", ")", "which", "we", "previously", "reported", "with", "improved", "response", "duration", "."], "h": {"id": "C0042679", "name": "C0042679#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417487", "name": "C1417487#ent", "pos": [16, 17]}}
{"token": ["rIL2", "stimulated", "C0024054#ent", "<e1>", ",", "Leu-11", "+", "and", "Leu-11-", "cells", "to", "produce", "C1539312#ent", "<e2>", "but", "not", "detectable", "GM-CSF", "or", "CFU-GM-inhibitory", "activity", "."], "h": {"id": "C0024054", "name": "C0024054#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1539312", "name": "C1539312#ent", "pos": [12, 13]}}
{"token": ["This", "C0002085#ent", "<e1>", "association", "with", "C1414558#ent", "<e2>", "was", "highly", "significant", "chi", "2", "=", "50.7", ";", "P", "<", ".0001", ")", "."], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1414558", "name": "C1414558#ent", "pos": [5, 6]}}
{"token": ["Our", "findings", "indicate", "that", "ceramides", "do", "not", "induce", "A1", "but", "do", "up-regulate", "C1623430#ent", "<e1>", "and", "induce", "C0669365#ent", "<e2>"], "h": {"id": "C1623430", "name": "C1623430#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [16, 17]}}
{"token": ["Inactivation", "of", "C1259877#ent", "<e1>", "inhibition", "of", "phosphatidylinositol-3", "kinase", "both", "B-Raf", "activation", "and", "EGF", "receptor-dependent", "C0752312#ent", "<e2>", "stimulation", "by", "Galpha(o", ")", "."], "h": {"id": "C1259877", "name": "C1259877#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0752312", "name": "C0752312#ent", "pos": [14, 15]}}
{"token": ["Partial", "albinism", "immunodeficiency", "(", "C1868679#ent", "<e1>", "is", "an", "uncommon", "disorder", "characterized", "by", "C0162835#ent", "<e2>", "variable", "immunodeficiency", "."], "h": {"id": "C1868679", "name": "C1868679#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0162835", "name": "C0162835#ent", "pos": [12, 13]}}
{"token": ["D-003", "is", "a", "mixture", "of", "high-molecular-weight", "acids", "purified", "from", "sugarcane", "wax", "inhibits", "cholesterol", "biosynthesis", "C0063164#ent", "<e1>", "preventing", "bone", "loss", "osteoporosis", "induced", "with", "ovariectomy", "and", "C0032950#ent", "<e2>", "in", "rats", "."], "h": {"id": "C0063164", "name": "C0063164#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0032950", "name": "C0032950#ent", "pos": [24, 25]}}
{"token": ["The", "effect", "of", "the", "combined", "application", "of", "the", "alpha", "2-adrenoreceptor", "C0009014#ent", "<e1>", "and", "of", "the", "C0242702#ent", "<e2>", "haloperidol", "on", "the", "memory", "processes", "was", "tested", "on", "albino", "rats", "."], "h": {"id": "C0009014", "name": "C0009014#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0242702", "name": "C0242702#ent", "pos": [15, 16]}}
{"token": ["The", "activities", "of", "alanine", "aminotransferase", "ALAT", ")", "and", "aspartate", "aminotransferase", "C1845028#ent", "<e1>", ")", "as", "well", "as", "the", "bile", "flow", "the", "C1705556#ent", "<e2>", "content", "were", "determined", "."], "h": {"id": "C1845028", "name": "C1845028#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [20, 21]}}
{"token": ["Nociceptin/orphanin", "FQ", "(", "N/OFQ", ")", ",", "the", "endogenous", "ligand", "of", "the", "opioid", "N/OFQ", "receptor", "(", "C1417756#ent", "<e1>", ")", ",", "possesses", "marked", "functional", "anti-stress", "and", "C1366488#ent", "<e2>", "CRF", ")", "actions", "."], "h": {"id": "C1417756", "name": "C1417756#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1366488", "name": "C1366488#ent", "pos": [24, 25]}}
{"token": ["The", "activity", "of", "C1382029#ent", "<e1>", "the", "yeast", "Saccharomyces", "cerevisiae", "controlled", "by", "two", "G-protein", "systems", "the", "C0242853#ent", "<e2>", "the", "Galpha", "protein", "Gpa2", "."], "h": {"id": "C1382029", "name": "C1382029#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0242853", "name": "C0242853#ent", "pos": [15, 16]}}
{"token": ["Numerous", "differences", "have", "been", "revealed", "in", "the", "C1517495#ent", "<e1>", "CPV-GRI", "DNA", "regions", ",", "C1334043#ent", "<e2>", "to", "fragments", "of", "the", "genomes", "of", "the", "above-mentioned", "orthopoxvirus", "strains"], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}}
{"token": ["The", "pAM", "beta", "1", "and", "Streptococcus", "agalactiae", "pIP501", ")", "C3273435#ent", "<e1>", "determinants", "appeared", "to", "have", "C1334468#ent", "<e2>", "but", "had", "similar", "internal", "973-", "or", "956-bp", "deletions", "in", "DR1", ",", "respectively", "."], "h": {"id": "C3273435", "name": "C3273435#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334468", "name": "C1334468#ent", "pos": [15, 16]}}
{"token": ["Growth", "factors", "insulin", "promote", "Akt/PKB-dependent", "phosphorylation", "of", "C0694895#ent", "<e1>", ",", "which", "in", "turn", ",", "releases", "C1419748#ent", "<e2>", "from", "negative", "regulation", "by", "C0694895#ent", "<e1>", "and", "results", "in", "the", "activation", "of", "C1419748#ent", "<e2>", "."], "h": {"id": "C1419748", "name": "C1419748#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0694895", "name": "C0694895#ent", "pos": [7, 8]}}
{"token": ["Mutations", "in", "the", "skeletal", "muscle", "C1419856#ent", "<e1>", "been", "found", "in", "patients", "with", "two", "distinct", "hereditary", "disorders", "sarcolemmal", "excitation", "C0238357#ent", "<e2>", "HYPP", ")", "and", "paramyotonia", "congenita", "PC", ")", "."], "h": {"id": "C1419856", "name": "C1419856#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0238357", "name": "C0238357#ent", "pos": [18, 19]}}
{"token": ["The", "permeation", "of", "lipophilic", "(", "C2348252#ent", "<e1>", ";", "D-Na", ")", "and", "hydrophilic", "(", "C0770456#ent", "<e2>", ";", "P-HCl", "model", "drugs", "were", "studied", "in", "vitro"], "h": {"id": "C2348252", "name": "C2348252#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0770456", "name": "C0770456#ent", "pos": [13, 14]}}
{"token": ["The", "effect", "of", "C0050537#ent", "<e1>", "ASA", ")", "on", "platelet", "aggregation", "C1418225#ent", "<e2>", ")", "and", "thromboxane", "A2", "TxA2", ")", "formation", "was", "investigated", "in", "vitro", "ex", "vivo", "1", "g", "or", "300", "mg", "ASA", "administration", "to", "healthy", "subjects"], "h": {"id": "C0050537", "name": "C0050537#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1418225", "name": "C1418225#ent", "pos": [10, 11]}}
{"token": ["Combined", "therapy", "Prednisolone", "and", "C0010583#ent", "<e1>", "had", "been", "given", "against", "C0027726#ent", "<e2>", "by", "purpura", "nephritis"], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [4, 5]}, "relation": "may_treat", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [10, 11]}}
{"token": ["In", "both", "studies", ",", "proof", "of", "principle", "was", "first", "established", "in", "the", "C0008533#ent", "<e1>", "with", "long-term", "expression", "of", "canine", "C1366464#ent", "<e2>", "at", "therapeutic", "levels", "before", "clinical", "studies", "initiated", "."], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [12, 13]}, "relation": "disease_has_associated_gene", "t": {"id": "C1366464", "name": "C1366464#ent", "pos": [19, 20]}}
{"token": ["To", "determine", "whether", "the", "features", "of", "syndrome", "X", "more", "common", "in", "first-degree", "relatives", "non-insulin-dependent", "diabetes", "mellitus", "C0011860#ent", "<e1>", ")", "patients", "than", "in", "control", "subjects", "no", "family", "history", "C0011847#ent", "<e2>", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [27, 28]}}
{"token": ["Protein", "purification", "by", "tryptic", "digestion", "mass", "spectra", "analysis", "allowed", "the", "identification", "of", "the", "70", "C1839259#ent", "<e1>", "and", "the", "65/60", "C1839259#ent", "<e1>", "molecules", "as", "PVR", "(", "C1419141#ent", "<e1>", ")", "and", "Nectin-2", "delta/alpha", "(", "CD112", ")", ",", "respectively", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1419141", "name": "C1419141#ent", "pos": [25, 26]}}
{"token": ["Hollow-type", "gold", "C1836075#ent", "<e1>", "modified", "with", "C0086140#ent", "<e2>", "were", "phagocytosed", "by", "macrophage", "cells"], "h": {"id": "C1836075", "name": "C1836075#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0086140", "name": "C0086140#ent", "pos": [6, 7]}}
{"token": ["This", "interest", "is", "justified", "by", "the", "strong", "association", "observed", "between", "these", "C0012634#ent", "<e1>", "and", "REM", "sleep", "behavior", "disorder", "C3146244#ent", "<e2>", ")", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3146244", "name": "C3146244#ent", "pos": [18, 19]}}
{"token": ["The", "ATM-controlled", "pathway", "includes", "the", "C3273855#ent", "<e1>", "and", "Nijmegen", "breakage", "syndrome", "but", "not", "the", "C0296594#ent", "<e2>", "whereas", "the", "ATR-regulated", "pathway", "includes", "its", "partner", "ATR-interacting", "protein", "not", "the", "Chk1", "kinase"], "h": {"id": "C3273855", "name": "C3273855#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0296594", "name": "C0296594#ent", "pos": [14, 15]}}
{"token": ["Extracellular", "signal-regulated", "kinase", "5", "ERK5", ")", ",", "the", "newest", "member", "of", "the", "mitogen-activated", "protein", "MAP", ")", "C1334324#ent", "<e1>", "is", "regulated", "differently", "than", "the", "other", "C0169101#ent", "<e2>"], "h": {"id": "C1334324", "name": "C1334324#ent", "pos": [16, 17]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0169101", "name": "C0169101#ent", "pos": [24, 25]}}
{"token": ["Its", "incidence", "in", "men", "is", "lower", ",", "associated", "with", "androgen", "on", "anabolic", "steroid", "treatment", ",", "C0011849#ent", "<e1>", ",", "storage", "diseases", "glycogenosis", "type", "I", "VI", ")", ",", "barbiturates", "and", "C0086213#ent", "<e2>", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086213", "name": "C0086213#ent", "pos": [28, 29]}}
{"token": ["The", "co-administration", "of", "C3494976#ent", "<e1>", "inhibitor", ",", "CGS27023A", ",", "with", "bleomycin", "resulted", "in", "worsening", "C0034069#ent", "<e2>", "inhibition", "of", "collagenase", "."], "h": {"id": "C3494976", "name": "C3494976#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034069", "name": "C0034069#ent", "pos": [14, 15]}}
{"token": ["Effects", "of", "C0001962#ent", "<e1>", "the", "morphology", "and", "conformational", "characteristics", "of", "silk", "sericin", "C1420041#ent", "<e2>", ")", "were", "studied", "."], "h": {"id": "C0001962", "name": "C0001962#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1420041", "name": "C1420041#ent", "pos": [12, 13]}}
{"token": ["C1417377#ent", "<e1>", "is", "a", "ubiquitously", "expressed", "serine-threonine", "kinase", "C1512488#ent", "<e2>", "to", "the", "budding", "yeast", "Ste20", "whose", "physiological", "regulation", "cellular", "function", "unknown", "."], "h": {"id": "C1417377", "name": "C1417377#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1512488", "name": "C1512488#ent", "pos": [8, 9]}}
{"token": ["Immunohistochemically", ",", "the", "tumor", "cells", "expressed", "strongly", "S100", "protein", "human", "melanoma", "black", "45", ",", "platelet-derived", "growth", "factor", "receptor", "alpha", "B-cell", "lymphoma", "2", "C1705526#ent", "<e1>", ",", "and", "to", "a", "lesser", "extent", "vimentin", ",", "C1880904#ent", "<e2>", "and", "epithelial", "membrane", "antigen"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C1880904", "name": "C1880904#ent", "pos": [32, 33]}}
{"token": ["Synthetic", "alamethicin", "analogs", ",", "in", "which", "all", "Aib", "residues", "had", "been", "replaced", "by", "Leu", "(L2", "then", "proline", "14", "by", "an", "alanine", "(", "C1969618#ent", "<e1>", ")", ",", "were", "studied", "in", "C0037506#ent", "<e2>", "micelles", "using", "circular", "dichroism", "NMR", "spectroscopy"], "h": {"id": "C1969618", "name": "C1969618#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0037506", "name": "C0037506#ent", "pos": [29, 30]}}
{"token": ["C1335439#ent", "<e1>", "transcript", "release", "factor", "(", "C1705002#ent", "<e2>", ")", "is", "in", "human", "adipocytes", "mainly", "localized", "at", "the", "plasma", "membrane"], "h": {"id": "C1335439", "name": "C1335439#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705002", "name": "C1705002#ent", "pos": [6, 7]}}
{"token": ["Five", "specimens", "had", "C1366463#ent", "<e1>", "and", "five", "had", "C1414833#ent", "<e2>", "at", "L4-L5", "."], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414833", "name": "C1414833#ent", "pos": [8, 9]}}
{"token": ["At", "36", "degrees", "C.", ",", "while", "C0035179#ent", "<e1>", "fails", "to", "potentiate", "C0039925#ent", "<e2>", ",", "chlorpromazine", "still", "does", "so", "."], "h": {"id": "C0035179", "name": "C0035179#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039925", "name": "C0039925#ent", "pos": [11, 12]}}
{"token": ["decreased", "nuclear", "accumulation", "the", "NF-kappaB", "p65", "subunit", "and", "conversely", ",", "ectopic", "activation", "of", "C1334481#ent", "<e1>", "led", "to", "constitutive", "nuclear", "localization", "C1420556#ent", "<e2>", "and", "increased", "its", "ability", "to", "trans", "activate", "reporter", "genes"], "h": {"id": "C1334481", "name": "C1334481#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1420556", "name": "C1420556#ent", "pos": [20, 21]}}
{"token": ["It", "implies", "that", "C0234233#ent", "<e1>", "contribute", "to", "the", "C0427055#ent", "<e2>", "experienced", "after", "a", "period", "of", "unaccustomed", "eccentric", "exercise", "."], "h": {"id": "C0234233", "name": "C0234233#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0427055", "name": "C0427055#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "the", "uptake", "of", "[(14)C]-UFX", "by", "isolated", "rat", "C0669372#ent", "<e1>", "was", "measured", ",", "and", "the", "effects", "of", "several", "C0597607#ent", "<e2>", "other", "quinolone", "antibiotics", "the", "uptake", "were", "examined", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0597607", "name": "C0597607#ent", "pos": [19, 20]}}
{"token": ["C0001309#ent", "<e1>", "best", "treated", "by", "local", "application", "antibiotics", "or", "C0038760#ent", "<e2>", "only", "."], "h": {"id": "C0001309", "name": "C0001309#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0038760", "name": "C0038760#ent", "pos": [9, 10]}}
{"token": ["The", "AMC5/B1", "line", "contained", "approximately", "5-fold", "decrease", "in", "C1336657#ent", "<e1>", "level", "and", "approximately", "2.5-fold", "decrease", "in", "C0256022#ent", "<e2>", "mRNA", "level", "."], "h": {"id": "C1336657", "name": "C1336657#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0256022", "name": "C0256022#ent", "pos": [16, 17]}}
{"token": ["Human", "topoisomerase", "IIalpha", "C1336657#ent", "<e1>", ")", "is", "encoded", "by", "the", "C0256022#ent", "<e2>", "chromosome", "17q21", "22", ",", "and", "human", "topoisomerase", "IIbeta", "TOP2B", ")", "is", "encoded", "by", "the", "TOP2B", "gene", "chromosome", "3p24"], "h": {"id": "C1336657", "name": "C1336657#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0256022", "name": "C0256022#ent", "pos": [10, 11]}}
{"token": ["Activation", "of", "C1366449#ent", "<e1>", "in", "the", "periphery", "is", "also", "considered", "to", "be", "a", "C1997362#ent", "<e2>", "mediator", "of", "inflammation", "that", "is", "involved", "in", "peptide", "release", "."], "h": {"id": "C1366449", "name": "C1366449#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1997362", "name": "C1997362#ent", "pos": [13, 14]}}
{"token": ["The", "presence", "of", "alpha-1-fetoprotein", ",", "the", "heat", "stable", "alkaline", "phosphatase", "Australia", "antigen", "examined", "in", "103", "patients", "with", "C0162566#ent", "<e1>", "300", "patients", "with", "C0023890#ent", "<e2>", "and", "18", "patients", "with", "primary", "liver", "carcinoma"], "h": {"id": "C0162566", "name": "C0162566#ent", "pos": [17, 18]}, "relation": "has_manifestation", "t": {"id": "C0023890", "name": "C0023890#ent", "pos": [22, 23]}}
{"token": ["We", "show", "that", "C4085342#ent", "<e1>", "is", "involved", "in", "the", "processing", "of", "murine", "C1413516#ent", "<e2>", "procathepsin", "G", "but", "does", "not", "process", "MC-pro-CPA", "or", "protryptase", "."], "h": {"id": "C4085342", "name": "C4085342#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413516", "name": "C1413516#ent", "pos": [12, 13]}}
{"token": ["In", "addition", ",", "phosphorylation", "of", "NR2A", "and", "NR2B", "C-terminal", "fusion", "proteins", "by", "C0812303#ent", "<e1>", "or", "Src", "enhanced", "their", "binding", "to", "spectrin", "and", "C1333226#ent", "<e2>", "."], "h": {"id": "C0812303", "name": "C0812303#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1333226", "name": "C1333226#ent", "pos": [22, 23]}}
{"token": ["Recently", ",", "Pitt-Rogers-Danks", "syndrome", "PRDS", ")", ",", "which", "is", "also", "due", "to", "a", "deletion", "of", "C1956097#ent", "<e1>", "has", "been", "shown", "to", "be", "allelic", "to", "C1710644#ent", "<e2>", "."], "h": {"id": "C1956097", "name": "C1956097#ent", "pos": [15, 16]}, "relation": "disease_has_associated_gene", "t": {"id": "C1710644", "name": "C1710644#ent", "pos": [24, 25]}}
{"token": ["Topics", "of", "interest", "included", "vitreous", "loss", "retained", "lens", "fragments", "diabetes", ",", "uveitis", ",", "C0220701#ent", "<e1>", "ocular", "hypotensive", "lipids", "internal", "limiting", "membrane", "peeling", ",", "and", "C0040864#ent", "<e2>", "injection", "."], "h": {"id": "C0220701", "name": "C0220701#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0040864", "name": "C0040864#ent", "pos": [24, 25]}}
{"token": ["Of", "ten", "bronchoscopic", "C1423088#ent", "<e1>", "isolates", ",", "seven", "were", "not", "related", "to", "C0024115#ent", "<e2>", "to", "dissemination", "within", "one", "month", "of", "FB", "."], "h": {"id": "C1423088", "name": "C1423088#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0024115", "name": "C0024115#ent", "pos": [12, 13]}}
{"token": ["Most", "cases", "are", "associated", "with", "malignant", "tumors", "non-malignant", "condition", "as", "porphyria", "cutanea", "tarda", "AIDS", ",", "anorexia", "nervosa", "C0040156#ent", "<e1>", ",", "or", "secondary", "to", "topical", "or", "C0243058#ent", "<e2>", "e.g.", "cyclosporine", ",", "phenytoin", ",", "diazoxide", ",", "minoxidil", ")", "."], "h": {"id": "C0040156", "name": "C0040156#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0243058", "name": "C0243058#ent", "pos": [25, 26]}}
{"token": ["Class", "I", "hemerythrin", ",", "C0067056#ent", "<e1>", ",", "and", ",", "possibly", ",", "C0292378#ent", "<e2>"], "h": {"id": "C0067056", "name": "C0067056#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0292378", "name": "C0292378#ent", "pos": [11, 12]}}
{"token": ["These", "data", "suggest", "that", "genetic", "predisposition", "the", "antitopo", "I", "response", "in", "C0036421#ent", "<e1>", "is", "associated", "most", "closely", "with", "the", "C1415572#ent", "<e2>"], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1415572", "name": "C1415572#ent", "pos": [19, 20]}}
{"token": ["While", "hormone", "replacement", "therapy", "HRT", ")", "has", "not", "been", "shown", "to", "be", "an", "effective", "treatment", "for", "major", "depression", ",", "preliminary", "studies", "that", "C2936882#ent", "<e1>", "may", "potentiate", "the", "effect", "of", "selective", "C2911696#ent", "<e2>"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C2911696", "name": "C2911696#ent", "pos": [30, 31]}}
{"token": ["Four", "factors", ",", "Cdx1", ",", "Cdx2", ",", "HNF1alpha", ",", "and", "C1420636#ent", "<e1>", ",", "could", "bind", "to", "C0751748#ent", "<e2>", "and", "transcriptionally", "activate", "the", "beta3Gal-T5", "gene"], "h": {"id": "C1420636", "name": "C1420636#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0751748", "name": "C0751748#ent", "pos": [16, 17]}}
{"token": ["The", "lesion-induced", "increases", "in", "GAD67", "transcripts", "were", "potentiated", "by", "L-dopa", "but", "unaffected", "by", "C0813872#ent", "<e1>", ",", "whereas", "the", "increases", "in", "C1414926#ent", "<e2>", "were", "suppressed", "by", "C0813872#ent", "<e1>", "but", "unaffected", "by", "L-dopa", "."], "h": {"id": "C1414926", "name": "C1414926#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0813872", "name": "C0813872#ent", "pos": [13, 14]}}
{"token": ["The", "modulation", "of", "cerebellar", "Purkinje", "cell", "and", "EEG", "from", "parietal", "cortex", "studied", "in", "the", "rat", "model", "of", "C0014547#ent", "<e1>", "induced", "by", "penicillin", "under", "C0018546#ent", "<e2>", "amphetamine", "treatment", "."], "h": {"id": "C0014547", "name": "C0014547#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0018546", "name": "C0018546#ent", "pos": [23, 24]}}
{"token": ["A", "combination", "of", "C0097109#ent", "<e1>", "and", "NO", "increased", "the", "level", "of", "single", "strand", "breaks", "C1420423#ent", "<e2>", ")", "in", "plasmid", "DNA", "by", "more", "than", "60", "%", "compared", "to", "vehicle", "controls", "a", "metal-free", "buffer", "system", "."], "h": {"id": "C0097109", "name": "C0097109#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420423", "name": "C1420423#ent", "pos": [14, 15]}}
{"token": ["Fractions", "were", "incubated", "with", "[gamma-32P]ATP", ",", "and", "labelling", "of", "C0063566#ent", "<e1>", "phosphatidylinositol", "4,5-bisphosphate", "used", "to", "measure", "C0089793#ent", "<e2>", "phosphatidylinositol", "4-phosphate", "kinase", ",", "respectively", "."], "h": {"id": "C0063566", "name": "C0063566#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0089793", "name": "C0089793#ent", "pos": [16, 17]}}
{"token": ["To", "assess", "peripheral", "vascular", "endothelial", "function", "in", "patients", "with", "C0152136#ent", "<e1>", "NTG", ")", "by", "using", "a", "noninvasive", "method", "endothelium-dependent", "flow-mediated", "vasodilation", "C3810599#ent", "<e2>", ")", "."], "h": {"id": "C0152136", "name": "C0152136#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C3810599", "name": "C3810599#ent", "pos": [21, 22]}}
{"token": ["Examined", "compounds", "inactive", "in", "both", "applied", "tests", ",", "where", "reference", "substances", "C1257966#ent", "<e1>", ",", "nitric", "oxide", "donors", "and", "C0040207#ent", "<e2>", ")", "inhibited", "non-enzymic", "lipid", "peroxidation", "and", "scavenged", "superoxide", "anions"], "h": {"id": "C1257966", "name": "C1257966#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0040207", "name": "C0040207#ent", "pos": [18, 19]}}
{"token": ["Cathepsin", "M", "which", "catalyzes", "inactivation", "of", "both", "rabbit", "C1414544#ent", "<e1>", "EC", "4.1.2.13", "and", "rabbit", "liver", "fructose", "1,6-bisphosphatase", "Fru-P2ase", ";", "C3889472#ent", "<e2>", ",", "has", "been", "characterized", "as", "a", "peptidyl", "peptidase"], "h": {"id": "C1414544", "name": "C1414544#ent", "pos": [8, 9]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3889472", "name": "C3889472#ent", "pos": [19, 20]}}
{"token": ["C0041834#ent", "<e1>", "Bazin", ",", "a", "chronic", "form", "C0042384#ent", "<e2>", "may", "be", "associated", "with", "chronic", "infections", "Mycobacterium", "tuberculosis"], "h": {"id": "C0041834", "name": "C0041834#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0042384", "name": "C0042384#ent", "pos": [7, 8]}}
{"token": ["To", "study", "prospectively", "two", "methods", "for", "the", "bacteriological", "diagnosis", "of", "osteomyelitis", "related", "to", "C1456868#ent", "<e1>", "needle", "puncture", "across", "normal", "skin", "the", "C0085119#ent", "<e2>", "superficial", "swabbing", "of", "the", "ulcer", "."], "h": {"id": "C1456868", "name": "C1456868#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0085119", "name": "C0085119#ent", "pos": [21, 22]}}
{"token": ["Human", "CYP2A6", "is", "a", "cytochrome", "P450", "CYP", ")", "isoform", "responsible", "for", "the", "metabolism", "of", "nicotine", ",", "C0010207#ent", "<e1>", ",", "tegafur", ",", "and", "C0042291#ent", "<e2>", "and", "metabolic", "activation", "nitrosamines", "."], "h": {"id": "C0010207", "name": "C0010207#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [22, 23]}}
{"token": ["In", "summary", ",", "our", "current", "data", "suggest", "that", "C0964965#ent", "<e1>", "can", "increase", "water", "and", "sodium", "reabsorption", "C0022672#ent", "<e2>", "stimulating", "the", "ENaC", "and", "Na", ",", "K-ATPase", "system", "."], "h": {"id": "C0964965", "name": "C0964965#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0022672", "name": "C0022672#ent", "pos": [16, 17]}}
{"token": ["Dopamine", "and", "C0003596#ent", "<e1>", "increased", "adenylate", "cyclase", "tubular", "membranes", "no", "increases", "were", "noted", "in", "C0268731#ent", "<e2>", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268731", "name": "C0268731#ent", "pos": [14, 15]}}
{"token": ["Preceding", "the", "two", "in", "vitro", "acylated", "HlyA", "lysines", "are", "glycines", "that", "appear", "to", "be", "the", "only", "C3539946#ent", "<e1>", "in", "alignments", "of", "these", "regions", "among", "the", "C0073081#ent", "<e2>"], "h": {"id": "C3539946", "name": "C3539946#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0073081", "name": "C0073081#ent", "pos": [25, 26]}}
{"token": ["The", "antimicrobial", "activity", "6-[(R)-2[3-methylsulfonyl-2-oxo-imidazolidine-1-carboxamido]-2-phenylacetamido]-penicillanic", "acid", "sodium", "salt", "(", "mezlocillin", ",", "Baypen", ")", "and", "6-[(R)-2-(2-oxo-imidazolidine-1-carboxamido)-2-phenylacetamido-a1-penicillanic", "C0142853#ent", "<e1>", "azlocillin", ",", "Securopen", ")", "was", "measured", "against", "545", "clinical", "C1875400#ent", "<e2>", ",", "including", "gram-negative", "rods", "gram-positive", "cocci", "Bacteroides", "."], "h": {"id": "C0142853", "name": "C0142853#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [25, 26]}}
{"token": ["Whereas", "C0008680#ent", "<e1>", "targets", "the", "lung", ",", "Churg-Strauss", "syndrome", "a", "C0085084#ent", "<e2>"], "h": {"id": "C0008680", "name": "C0008680#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0085084", "name": "C0085084#ent", "pos": [10, 11]}}
{"token": ["We", "conclude", "that", "the", "vasorelaxant", "effects", "of", "C0546849#ent", "<e1>", "are", "mediated", "via", "inhibition", "of", "C1334539#ent", "<e2>", "protein", "kinase", "C", "in", "addition", "to", "the", "inhibition", "of", "Ca2", "+", "influx", "."], "h": {"id": "C0546849", "name": "C0546849#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1334539", "name": "C1334539#ent", "pos": [14, 15]}}
{"token": ["In", "addition", ",", "some", "C0084378#ent", "<e1>", "such", "as", "BLM", "and", "C0388246#ent", "<e2>", "interact", "physically", "and", "functionally", "with", "telomerases", "and", "are", "involved", "in", "telomere", "maintenance", "."], "h": {"id": "C0084378", "name": "C0084378#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0388246", "name": "C0388246#ent", "pos": [10, 11]}}
{"token": ["The", "aims", "of", "the", "study", "were", "to", "investigate", "C3540613#ent", "<e1>", "concentrations", "in", "the", "vitreous", "fluid", "patients", "with", "C0154830#ent", "<e2>", "PDR", ")", "and", "to", "evaluate", "the", "relationship", "between", "C3540613#ent", "<e1>", "and", "vascular", "endothelial", "growth", "factor", "VEGF", ")", "."], "h": {"id": "C3540613", "name": "C3540613#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0154830", "name": "C0154830#ent", "pos": [17, 18]}}
{"token": ["Acetate", "kinase", "a", "member", "of", "the", "ASKHA", "(", "Acetate", "and", "Sugar", "Kinases", ",", "C1527149#ent", "<e1>", ",", "Actin", ")", "phosphotransferase", "superfamily", "a", "central", "enzyme", "prokaryotic", "C0524928#ent", "<e2>", "and", "energy", "metabolism"], "h": {"id": "C1527149", "name": "C1527149#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0524928", "name": "C0524928#ent", "pos": [24, 25]}}
{"token": ["Among", "the", "synthetic", "substances", ",", "vasoactive", "intestinal", "peptide", "VIP", ")", ",", "C1421143#ent", "<e1>", "TRH", ")", "and", "beta-endorphin", "(", "C1704837#ent", "<e2>", ")", "showed", "significant", "PRA", "."], "h": {"id": "C1421143", "name": "C1421143#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1704837", "name": "C1704837#ent", "pos": [18, 19]}}
{"token": ["C1815010#ent", "<e1>", "treatment", "increased", "activities", "of", "antioxidant", "C3541394#ent", "<e2>", "and", "expression", "of", "Bcl-2", "in", "healthy", "rats", "as", "well", "as", "diabetic", "rats", "."], "h": {"id": "C1815010", "name": "C1815010#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [7, 8]}}
{"token": ["Such", "Na", "retention", "the", "roots", "together", "with", "the", "special", "possibilities", "of", "C0524928#ent", "<e1>", "reutilization", "given", "by", "C1861821#ent", "<e2>", "are", "apparently", "survival", "mechanisms", "the", "temporarily", "saline", "conditions", "experienced", "in", "its", "natural", "habitat", "."], "h": {"id": "C0524928", "name": "C0524928#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1861821", "name": "C1861821#ent", "pos": [16, 17]}}
{"token": ["Furthermore", ",", "in", "C2936882#ent", "<e1>", "responsive", "xenotransplants", ",", "changes", "in", "the", "level", "of", "C1708416#ent", "<e2>", "mRNA", "correlate", "directly", "with", "estrogen-mediated", "changes", "in", "tumor", "growth"], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1708416", "name": "C1708416#ent", "pos": [13, 14]}}
{"token": ["These", "data", "show", "that", "Nef", "selectively", "activates", "Hck", ",", "C1442804#ent", "<e1>", ",", "and", "c-Src", "among", "SFKs", ",", "identifying", "these", "C0031727#ent", "<e2>", "as", "proximal", "effectors", "of", "Nef", "signaling", "potential", "targets", "for", "anti-HIV", "drug", "discovery"], "h": {"id": "C1442804", "name": "C1442804#ent", "pos": [9, 10]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [19, 20]}}
{"token": ["Two-thirds", "of", "those", "with", "C0031065#ent", "<e1>", "gave", "a", "history", "of", "a", "preceeding", "C0035243#ent", "<e2>", "compared", "with", "one-third", "of", "the", "controls", ")", "."], "h": {"id": "C0031065", "name": "C0031065#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0035243", "name": "C0035243#ent", "pos": [12, 13]}}
{"token": ["Activation", "of", "phagocytes", "(", "alveolar", "macrophages", "C1426677#ent", "<e1>", "]", "and", "neutrophil", "polymorphonuclear", "leukocytes", "PMN", "]", ")", "can", "cause", "tissue", "damage", "C0033581#ent", "<e2>"], "h": {"id": "C1426677", "name": "C1426677#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0033581", "name": "C0033581#ent", "pos": [20, 21]}}
{"token": ["Immunostaining", "of", "TAs", "was", "also", "seen", "with", "antibodies", "against", "heat", "shock", "protein", "C1414209#ent", "<e1>", ",", "but", "not", "with", "antibodies", "to", "C1416877#ent", "<e2>", "dystrophin", ",", "adhalin", ",", "beta", ",", "gamma", ",", "delta", "sarcoglycans", "and", "merosin", "."], "h": {"id": "C1414209", "name": "C1414209#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1416877", "name": "C1416877#ent", "pos": [20, 21]}}
{"token": ["Of", "the", "140", "polymorphic", "sites", ",", "68", "were", "located", "in", "the", "coding", "region", "of", "which", "28", "created", "C2917660#ent", "<e1>", "substitutions", "in", "C1420307#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1420307", "name": "C1420307#ent", "pos": [21, 22]}}
{"token": ["F9", "cells", "secreted", "newly", "synthesized", "C1412481#ent", "<e1>", "when", "incubated", "with", "radiolabeled", "C2917660#ent", "<e2>"], "h": {"id": "C1412481", "name": "C1412481#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2917660", "name": "C2917660#ent", "pos": [11, 12]}}
{"token": ["Little", "treatment", "data", "exist", "to", "direct", "the", "clinician", "to", "proper", "management", "of", "rare", "C0003864#ent", "<e1>", "from", "osteosclerotic", "myeloma", "POEMS", "syndrome", ";", "vasculitis", ";", "C1527336#ent", "<e2>", "and", "neoplasia", "(", "paraneoplastic", "neuropathy", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [13, 14]}, "relation": "related_to", "t": {"id": "C1527336", "name": "C1527336#ent", "pos": [23, 24]}}
{"token": ["This", "structure", "suggests", "that", "the", "parasite", "might", "contain", "a", "novel", "C1333828#ent", "<e1>", "that", "can", "add", "C4283926#ent", "<e2>", "to", "terminal", "GlcNAc", "residues", "in", "N-linked", "oligosaccharides"], "h": {"id": "C1333828", "name": "C1333828#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C4283926", "name": "C4283926#ent", "pos": [15, 16]}}
{"token": ["Most", "patients", "with", "acute", "vertigo", "C0027498#ent", "<e1>", ",", "and", "unsteady", "gait", "benign", "APV", "(", "vestibular", "neuritis", "C0022893#ent", "<e2>", ")", "as", "a", "cause", "."], "h": {"id": "C0027498", "name": "C0027498#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0022893", "name": "C0022893#ent", "pos": [16, 17]}}
{"token": ["2", "The", "expression", "of", "NO", "synthase", "NOS", ")", ",", "C1565860#ent", "<e1>", "(", "COX", ")", "isoforms", ",", "soluble", "C0671566#ent", "<e2>", "superoxide", "dismutase", "the", "NAD(P)H", "oxidase", "subunits", ")", "and", "p", "47(phox", ")", "were", "determined", "."], "h": {"id": "C1565860", "name": "C1565860#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0671566", "name": "C0671566#ent", "pos": [17, 18]}}
{"token": ["Unlike", "complexing", "agents", "such", "as", "C0108171#ent", "<e1>", ",", "cyclodextrines", "or", "C0010583#ent", "<e2>", ",", "reactands", "form", "a", "reversible", "covalent", "bond", "the", "analyte", "molecule"], "h": {"id": "C0108171", "name": "C0108171#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0010583", "name": "C0010583#ent", "pos": [10, 11]}}
{"token": ["Infusion", "of", "C0020924#ent", "<e1>", ",", "a", "thromboxane", "A2", "synthetase", "blocker", "did", "not", "reduce", "C3540498#ent", "<e2>", "after", "release", "of", "BUO", "."], "h": {"id": "C0020924", "name": "C0020924#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3540498", "name": "C3540498#ent", "pos": [13, 14]}}
{"token": ["We", "show", "here", "that", "budding", "yeast", "peptidyl-tRNA", "hydrolase", "2", "(", "C1842125#ent", "<e1>", ")", ",", "which", "was", "previously", "recognized", "as", "a", "C0051616#ent", "<e2>", "is", "a", "UBL", "domain-binding", "protein", "participates", "in", "the", "ubiquitin-proteasome", "pathway"], "h": {"id": "C1842125", "name": "C1842125#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0051616", "name": "C0051616#ent", "pos": [20, 21]}}
{"token": ["These", "results", "indicate", "that", "compound", "6L", "is", "a", "potent", "and", "specific", "C0235480#ent", "<e1>", "antagonist", "with", "C0220821#ent", "<e2>", "devoid", "of", "a", "significant", "cardiovascular", "activity", "to", "calcium-antagonist", "properties", "."], "h": {"id": "C0235480", "name": "C0235480#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0220821", "name": "C0220821#ent", "pos": [15, 16]}}
{"token": ["Two", "different", "monoclonal", "antibodies", "B7", "and", "C2981726#ent", "<e1>", ",", "were", "used", "to", "visualise", "C0055673#ent", "<e2>", "in", "purified", "lung", "mast", "cells", "two", "patients", "using", "ultrastructural", "immunogold", "labelling", "."], "h": {"id": "C2981726", "name": "C2981726#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0055673", "name": "C0055673#ent", "pos": [13, 14]}}
{"token": ["C1443768#ent", "<e1>", ",", "such", "as", "C1337242#ent", "<e2>", "(", "Cin", ")", ",", "increase", "the", "sensitivity", "of", "the", "CaR", "to", "Ca", "."], "h": {"id": "C1443768", "name": "C1443768#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337242", "name": "C1337242#ent", "pos": [5, 6]}}
{"token": ["A", "56", "year", "old", "male", "developed", "bilateral", "massive", "adrenal", "haemorrhage", "BMAH", ")", "resulting", "in", "C0403447#ent", "<e1>", "the", "course", "of", "C0272285#ent", "<e2>"], "h": {"id": "C0403447", "name": "C0403447#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0272285", "name": "C0272285#ent", "pos": [19, 20]}}
{"token": ["C0060135#ent", "<e1>", "is", "a", "new", "C0003299#ent", "<e2>", "glutamate", "antagonist", "GABA", "agonist", "properties", "."], "h": {"id": "C0060135", "name": "C0060135#ent", "pos": [0, 1]}, "relation": "has_therapeutic_class", "t": {"id": "C0003299", "name": "C0003299#ent", "pos": [5, 6]}}
{"token": ["The", "C0039082#ent", "<e1>", "TAZ", "has", "been", "identified", "and", "expression", "of", "the", "C0079429#ent", "<e2>", "yields", "proteins", "known", "as", "tafazzins", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [11, 12]}}
{"token": ["The", "rates", "of", "C0452138#ent", "<e1>", "disabilities", "in", "survivors", "fell", "significantly", "between", "the", "first", "2", "C1415714#ent", "<e2>", ",", "and", "remained", "low", "in", "the", "last", "era", "."], "h": {"id": "C0452138", "name": "C0452138#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1415714", "name": "C1415714#ent", "pos": [14, 15]}}
{"token": ["1,3,4-Thiadiazol-2-ylcyanamide", "(", "C0126339#ent", "<e1>", ")", "and", "its", "sodium", "salt", "shown", "to", "be", "effective", "against", "C0021400#ent", "<e2>", "B", "viruses", "in", "vitro", "in", "the", "mouse", "model"], "h": {"id": "C0126339", "name": "C0126339#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0021400", "name": "C0021400#ent", "pos": [14, 15]}}
{"token": ["Laboratory", "values", "compatible", "with", "anterior", "(", "abnormal", "concentrations", "of", "adrenocorticotropin", "hormone", "thyroid", "stimulating", "hormone", "C1418938#ent", "<e1>", ")", "and", "posterior", "(", "C1366535#ent", "<e2>", "pituitary", "gland", "insufficiency"], "h": {"id": "C1418938", "name": "C1418938#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1366535", "name": "C1366535#ent", "pos": [20, 21]}}
{"token": ["Activation", "of", "AKT", "by", "phosphatidylinositide-3", "kinase", "PI3K", ",", "a", "C0034678#ent", "<e1>", "effector", ",", "results", "in", "C0244988#ent", "<e2>", "phosphorylation", "and", "deactivation", "and", "subsequent", "beta-catenin", "upregulation", "in", "thyroid", "cancer"], "h": {"id": "C0034678", "name": "C0034678#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0244988", "name": "C0244988#ent", "pos": [15, 16]}}
{"token": ["Compared", "with", "normal", "T", "B", "cells", "LAX(-/-", ")", "T", "and", "B", "cells", "C0085129#ent", "<e1>", "and", "had", "enhanced", "calcium", "flux", "protein", "tyrosine", "phosphorylation", "MAPK", "and", "C0812228#ent", "<e2>", "activation", ",", "and", "cell", "survival", "engagement", "of", "the", "T", "or", "B", "AgRs", "."], "h": {"id": "C0085129", "name": "C0085129#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0812228", "name": "C0812228#ent", "pos": [24, 25]}}
{"token": ["Concentration", "of", "acetylcholine", "(", "ACh", ")", "in", "the", "perfusate", "was", "determined", "by", "high-performance", "liquid", "chromatography", "detection", "(", "C1825023#ent", "<e1>", ")", "with", "the", "enzyme-column", "on", "which", "acetylcholine", "esterase", "C0055571#ent", "<e2>", "immobilized", "."], "h": {"id": "C1825023", "name": "C1825023#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0055571", "name": "C0055571#ent", "pos": [27, 28]}}
{"token": ["The", "2", "patients", "with", "C0014548#ent", "<e1>", "both", "of", "whom", "were", "conscious", "during", "C3537320#ent", "<e2>", ",", "survived", "without", "sequelae", "."], "h": {"id": "C0014548", "name": "C0014548#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3537320", "name": "C3537320#ent", "pos": [12, 13]}}
{"token": ["Animals", "with", "low", "CETP", "and", "high", "C1334332#ent", "<e1>", "activities", "appear", "to", "be", "more", "sensitive", "to", "C0218076#ent", "<e2>", "than", "those", "with", "high", "CETP", "and", "low", "C1334332#ent", "<e1>", "activities", "."], "h": {"id": "C1334332", "name": "C1334332#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0218076", "name": "C0218076#ent", "pos": [15, 16]}}
{"token": ["These", "results", "suggest", "that", "a", "C0001637#ent", "<e1>", "stimulus", "increases", "progesterone", "release", "from", "the", "ovary", "on", "C3889128#ent", "<e2>", "and", "decreases", "it", "on", "D2", "."], "h": {"id": "C0001637", "name": "C0001637#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [15, 16]}}
{"token": ["Compared", "with", "other", "C3536840#ent", "<e1>", "NSAIDs", ")", "for", "local", "usage", "C2748507#ent", "<e2>", "is", "thus", "evidently", "well", "differentiated", "and", "innovative", "."], "h": {"id": "C3536840", "name": "C3536840#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2748507", "name": "C2748507#ent", "pos": [10, 11]}}
{"token": ["It", "may", "provide", "possibility", "that", "C0248719#ent", "<e1>", "works", "as", "a", "potential", "agent", "against", "C0011881#ent", "<e2>", "hypertensive", "renal", "disease"], "h": {"id": "C0248719", "name": "C0248719#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0011881", "name": "C0011881#ent", "pos": [13, 14]}}
{"token": ["Although", "Pim-1", "or", "C1453189#ent", "<e1>", "can", "contribute", "to", "lymphoid", "transformation", "overexpressed", ",", "the", "physiologic", "role", "these", "C0031727#ent", "<e2>", "in", "the", "immune", "response", "uncertain", "."], "h": {"id": "C1453189", "name": "C1453189#ent", "pos": [3, 4]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031727", "name": "C0031727#ent", "pos": [16, 17]}}
{"token": ["For", "analytical", "runs", "eluate", "is", "mixed", "with", "o-phthalaldehyde", "in", "C0991799#ent", "<e1>", "Brij", "35", "and", "C0000294#ent", "<e2>", "prior", "to", "its", "passage", "into", "the", "detector", "."], "h": {"id": "C0991799", "name": "C0991799#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0000294", "name": "C0000294#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", ",", "we", "examined", "the", "possible", "interaction", "among", "interleukin-1alpha", "(", "IL-1alpha", ")", ",", "IL-4", ",", "IL-6", ",", "and", "steroid", "C4284131#ent", "<e1>", "enzymes", "(", "UGT2B15", "and", "C1421339#ent", "<e2>", ")", "."], "h": {"id": "C4284131", "name": "C4284131#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1421339", "name": "C1421339#ent", "pos": [27, 28]}}
{"token": ["This", "increase", "in", "glucose", "transport", "prevented", "by", "the", "SR", "calcium", "channel", "blocker", "C0010977#ent", "<e1>", "and", "the", "C0769224#ent", "<e2>", "inhibitor", "KN93", "."], "h": {"id": "C0010977", "name": "C0010977#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0769224", "name": "C0769224#ent", "pos": [16, 17]}}
{"token": ["To", "clarify", "how", "the", "C0079933#ent", "<e1>", "Abelson", "murine", "leukemia", "virus", "to", "lymphoid", "tumorigenesis", ",", "we", "introduced", "the", "C0017337#ent", "<e2>", "linked", "to", "an", "immunoglobulin", "heavy", "chain", "enhancer", "E", "mu", "into", "the", "mouse", "germline"], "h": {"id": "C0079933", "name": "C0079933#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [17, 18]}}
{"token": ["Understanding", "the", "control", "and", "expression", "of", "this", "C1413746#ent", "<e1>", "shed", "light", "on", "the", "mechanism(s", ")", "of", "C0242957#ent", "<e2>", "its", "potential", "role", "in", "the", "pathogenesis", "of", "human", "adenocarcinomas", "."], "h": {"id": "C1413746", "name": "C1413746#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242957", "name": "C0242957#ent", "pos": [16, 17]}}
{"token": ["Mice", "with", "exacerbated", "C0032285#ent", "<e1>", "showed", "enhanced", "C0042769#ent", "<e2>", "the", "lungs", "and", "histopathological", "lesions", "similar", "to", "those", "found", "in", "human", "SARS", "cases", "."], "h": {"id": "C0032285", "name": "C0032285#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [7, 8]}}
{"token": ["This", "mutation", ",", "previously", "considered", "a", "model", "of", "amyotrophic", "lateral", "sclerosis", "may", "be", "a", "useful", "model", "for", "molecular", "and", "genetic", "studies", "human", "neuronal", "ceroid", "C0268279#ent", "<e1>", "because", "mice", "have", "been", "well", "characterized", "C1516876#ent", "<e2>", "."], "h": {"id": "C0268279", "name": "C0268279#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1516876", "name": "C1516876#ent", "pos": [32, 33]}}
{"token": ["The", "urea", "cycle", "disorders", "a", "group", "of", "rare", "C0242354#ent", "<e1>", "by", "a", "deficiency", "of", "the", "C3540790#ent", "<e2>", "or", "transport", "proteins", "to", "remove", "ammonia", "from", "the", "body", "."], "h": {"id": "C0242354", "name": "C0242354#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [15, 16]}}
{"token": ["These", "effects", "were", "blocked", "by", "both", "the", "C2927149#ent", "<e1>", "SR141716A", "and", "the", "C3536879#ent", "<e2>", "naloxone", "."], "h": {"id": "C2927149", "name": "C2927149#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3536879", "name": "C3536879#ent", "pos": [12, 13]}}
{"token": ["These", "findings", "support", "the", "hypothesis", "that", "C0812273#ent", "<e1>", "is", "a", "tumor", "suppressor", "schwannomas", "in", "the", "context", "of", "C0277558#ent", "<e2>"], "h": {"id": "C0812273", "name": "C0812273#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0277558", "name": "C0277558#ent", "pos": [17, 18]}}
{"token": ["TBI", "caused", "significant", "time-dependent", "upregulation", "of", "CSP", "activity", ",", "but", "not", "C0758336#ent", "<e1>", "in", "injured", "C0001614#ent", "<e2>", "."], "h": {"id": "C0758336", "name": "C0758336#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [15, 16]}}
{"token": ["Sindbis", "(", "SIND", ")", ",", "C0266999#ent", "<e1>", "VSV", ")", "Chandipura", "(", "C1846989#ent", "<e2>", ")", "and", "African", "horse", "sickness", "AHS", ")", "viruses", "multiplied", "in", "these", "cultures", "."], "h": {"id": "C0266999", "name": "C0266999#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1846989", "name": "C1846989#ent", "pos": [11, 12]}}
{"token": ["Food", "does", "not", "affect", "the", "absorption", "of", "C0754188#ent", "<e1>", "following", "administration", "of", "the", "C1321661#ent", "<e2>", ";", "therefore", ",", "fosamprenavir", "tablets", "may", "be", "administered", "without", "regard", "to", "food", "intake"], "h": {"id": "C0754188", "name": "C0754188#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1321661", "name": "C1321661#ent", "pos": [13, 14]}}
{"token": ["The", "gammadelta", "T", "cells", "an", "intrinsic", "preference", "for", "C4284739#ent", "<e1>", "+", "and", "major", "C0024518#ent", "<e2>", "leukocytes", "."], "h": {"id": "C4284739", "name": "C4284739#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0024518", "name": "C0024518#ent", "pos": [13, 14]}}
{"token": ["The", "sequence", "encoding", "the", "viral", "leader", "proteinase", "C3714956#ent", "<e1>", "was", "replaced", "by", "the", "murine", "C1421262#ent", "<e2>", "a", "full-length", "cDNA", "clone", "the", "classical", "swine", "fever", "virus", "CSFV", ")", "strain", "Alfort/187", "."], "h": {"id": "C3714956", "name": "C3714956#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1421262", "name": "C1421262#ent", "pos": [14, 15]}}
{"token": ["The", "C1567710#ent", "<e1>", "Trypanosoma", "brucei", "transcribed", "in", "an", "alpha-amanitin", "resistant", "manner", ",", "and", "it", "has", "been", "proposed", "that", "RNA", "polymerase", "I", "rather", "than", "C0035680#ent", "<e2>", "transcribes", "the", "C1567710#ent", "<e1>"], "h": {"id": "C0035680", "name": "C0035680#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C1567710", "name": "C1567710#ent", "pos": [1, 2]}}
{"token": ["The", "response", "to", "FMRFamide", "was", "relatively", "insensitive", "to", "extracellular", "tetraethylammonium", "TEA", ",", "C1839259#ent", "<e1>", "approximately", "75", "mM", ")", "and", "4-aminopyridine", "(", "C0000477#ent", "<e2>", ",", "C1839259#ent", "<e1>", "approximately", "6", "mM", ")", "."], "h": {"id": "C1839259", "name": "C1839259#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0000477", "name": "C0000477#ent", "pos": [21, 22]}}
{"token": ["To", "better", "understand", "this", "relationship", ",", "we", "systematically", "performed", "functional", "analyses", "previously", "identified", "single", "nucleotide", "variants", "C1416917#ent", "<e1>", ",", "FZD4", "and", "NDP", ",", "utilizing", "the", "C1417616#ent", "<e2>", "dependent", "Topflash", "reporter", "assay", "."], "h": {"id": "C1416917", "name": "C1416917#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C1417616", "name": "C1417616#ent", "pos": [25, 26]}}
{"token": ["The", "rises", "in", "[Ca2+]i", "in", "response", "to", "10", "microM", "PGF(2alpha", ")", "and", "0.01", "microM", "C0917834#ent", "<e1>", "were", "partially", "inhibited", "by", "C0282138#ent", "<e2>", "."], "h": {"id": "C0917834", "name": "C0917834#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0282138", "name": "C0282138#ent", "pos": [20, 21]}}
{"token": ["As", "more", "patients", "with", "hepatic", "cirrhosis", "live", "through", "episodes", "of", "gastrointestinal", "bleeding", "C0019151#ent", "<e1>", "death", "in", "C3854173#ent", "<e2>", "undoubtedly", "become", "more", "common", "."], "h": {"id": "C0019151", "name": "C0019151#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3854173", "name": "C3854173#ent", "pos": [16, 17]}}
{"token": ["C0037275#ent", "<e1>", "association", "with", "C0019693#ent", "<e2>", "extremely", "rare", "."], "h": {"id": "C0037275", "name": "C0037275#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019693", "name": "C0019693#ent", "pos": [4, 5]}}
{"token": ["C0051510#ent", "<e1>", "potentiated", "these", "effects", "of", "C2744579#ent", "<e2>", ",", "suggesting", "a", "possible", "link", "with", "the", "aetiology", "of", "amyloidoses", "in", "vivo"], "h": {"id": "C0051510", "name": "C0051510#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [6, 7]}}
{"token": ["The", "NO-induced", "cytostasis", "was", "not", "reversed", "by", "inhibitors", "of", "C1367798#ent", "<e1>", "poly(ADP-ribose)polymerase", ",", "or", "by", "treatments", "that", "bypass", "inhibition", "C0035547#ent", "<e2>", "ornithine", "decarboxylase"], "h": {"id": "C1367798", "name": "C1367798#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0035547", "name": "C0035547#ent", "pos": [19, 20]}}
{"token": ["To", "study", "the", "functional", "status", "health-related", "quality", "of", "life", "HRQOL", ")", "of", "patients", "with", "C0003873#ent", "<e1>", "RA", ")", "after", "treatment", "with", "C0538927#ent", "<e2>", ",", "compared", "with", "placebo", "and", "naproxen", "."], "h": {"id": "C0003873", "name": "C0003873#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0538927", "name": "C0538927#ent", "pos": [21, 22]}}
{"token": ["Because", "of", "its", "spectrum", "of", "activity", ",", "C0040263#ent", "<e1>", "was", "used", "in", "a", "patient", "with", "recurrent", "C0085166#ent", "<e2>"], "h": {"id": "C0040263", "name": "C0040263#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0085166", "name": "C0085166#ent", "pos": [16, 17]}}
{"token": ["The", "antagonism", "produced", "by", "C0288343#ent", "<e1>", "was", "specific", "for", "CCK", "in", "that", "the", "effects", "of", "receptor", "secretagogues", "C0991617#ent", "<e2>", "bypassing", "receptors", "were", "not", "altered", "."], "h": {"id": "C0288343", "name": "C0288343#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0991617", "name": "C0991617#ent", "pos": [17, 18]}}
{"token": ["C3889721#ent", "<e1>", "could", "effectively", "control", "C0024530#ent", "<e2>", "compared", "to", "the", "basin", "released", "predators", "."], "h": {"id": "C3889721", "name": "C3889721#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [5, 6]}}
{"token": ["Among", "current", "and", "former", "smokers", "the", "odds", "ratio", "OR", ")", "for", "having", "C0010068#ent", "<e1>", "among", "patients", "with", "at", "least", "one", "C1705754#ent", "<e2>", "3.58", "(", "1.45", "-", "9.53", ",", "P", "<", "0.01", ")", "."], "h": {"id": "C0010068", "name": "C0010068#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1705754", "name": "C1705754#ent", "pos": [20, 21]}}
{"token": ["Estrogen", "sulfotransferase", "EST", ";", "SULT", "1E1", "or", "STE", "gene", "C3536834#ent", "<e1>", "estrogens", "to", "inactive", "estrogen", "sulfates", "whereas", "steroid", "sulfatase", "STS", ")", "hydrolyzes", "C0052456#ent", "<e2>", "estrone", "."], "h": {"id": "C3536834", "name": "C3536834#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0052456", "name": "C0052456#ent", "pos": [22, 23]}}
{"token": ["Inhibition", "of", "C1335654#ent", "<e1>", "activity", "with", "the", "CBFbeta-SMMHC", "or", "AML1-ETO", "oncoproteins", "reduced", "C1413175#ent", "<e2>", "expression", ",", "and", "C1335654#ent", "<e1>", "bound", "and", "activated", "the", "cyclin", "D3", "promoter", "."], "h": {"id": "C1413175", "name": "C1413175#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1335654", "name": "C1335654#ent", "pos": [2, 3]}}
{"token": ["The", "antiestrogens", "tamoxifen", "4-OH", "tamoxifen", "and", "C0027328#ent", "<e1>", "produce", "similar", "increases", "in", "C0567085#ent", "<e2>", "VEGF", "mRNA", "levels", "within", "6", "h", ",", "with", "1", "mg/kg", "tamoxifen", "producing", "a", "maximum", "response", "of", "15", "-", "20-fold", "."], "h": {"id": "C0027328", "name": "C0027328#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0567085", "name": "C0567085#ent", "pos": [12, 13]}}
{"token": ["They", "differed", "from", "other", "kallikrein-related", "proteinases", "having", "high", "C1704947#ent", "<e1>", "values", "of", "6.20", "(", "C1420464#ent", "<e2>", ")", "and", "6.85", "(", "rK9", ")", "."], "h": {"id": "C1704947", "name": "C1704947#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420464", "name": "C1420464#ent", "pos": [14, 15]}}
{"token": ["Results", "showed", "transcription", "of", "cLhx9", ",", "cGATA4", ",", "cVnnl", ",", "cPptl", ",", "C3275264#ent", "<e1>", "were", "sexually", "dimorphic", "chicken", "gonadal", ",", "whereas", "cEki2", ",", "C1424490#ent", "<e2>", "were", "expressed", "at", "similar", "levels", "in", "both", "sexes", "."], "h": {"id": "C3275264", "name": "C3275264#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1424490", "name": "C1424490#ent", "pos": [23, 24]}}
{"token": ["In", "vivo", "C1705616#ent", "<e1>", "induced", "the", "expression", "of", "immediate-early", "genes", "products", "c-Fos", "protein", "C1414314#ent", "<e2>", ",", "and", "BDNF", "mRNAs", ")", ",", "and", "this", "induction", "was", "prevented", "by", "an", "inhibitor", "of", "MEK", "."], "h": {"id": "C1705616", "name": "C1705616#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1414314", "name": "C1414314#ent", "pos": [13, 14]}}
{"token": ["C1417815#ent", "<e1>", "proneurogenic", "properties", "are", "mediated", "via", "the", "C1417816#ent", "<e2>"], "h": {"id": "C1417815", "name": "C1417815#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417816", "name": "C1417816#ent", "pos": [8, 9]}}
{"token": ["Phenylalanine", "hydroxylase", "C0041491#ent", "<e1>", "and", "tryptophan", "hydroxylase", "a", "small", "family", "C0020364#ent", "<e2>", "that", "utilize", "tetrahydropterins", "as", "substrates", "."], "h": {"id": "C0041491", "name": "C0041491#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0020364", "name": "C0020364#ent", "pos": [10, 11]}}
{"token": ["This", "difference", "of", "Km", "values", "suggested", "that", "aldehyde", "reductase", "than", "aldose", "reductase", "mainly", "responsible", "for", "reducing", "glucose", "to", "C0037688#ent", "<e1>", "in", "the", "C0023899#ent", "<e2>", "."], "h": {"id": "C0037688", "name": "C0037688#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0023899", "name": "C0023899#ent", "pos": [22, 23]}}
{"token": ["We", "determined", "the", "incidence", "of", "hypercalciuria", "(", "HC", ")", "and", "its", "association", "with", "nephrocalcinosis", "and", "C0392525#ent", "<e1>", "in", "18", "consecutive", "patients", "with", "C0004903#ent", "<e2>", "BWS", ")", "."], "h": {"id": "C0392525", "name": "C0392525#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0004903", "name": "C0004903#ent", "pos": [22, 23]}}
{"token": ["Each", "analogue", "was", "tested", "in", "vitro", "the", "protozoa", "C0017536#ent", "<e1>", "Trichomonas", "vaginalis", "comparison", "with", "C0001911#ent", "<e2>", "and", "metronidazole", "."], "h": {"id": "C0017536", "name": "C0017536#ent", "pos": [8, 9]}, "relation": "may_be_treated_by", "t": {"id": "C0001911", "name": "C0001911#ent", "pos": [14, 15]}}
{"token": ["Overall", ",", "we", "demonstrated", "that", "RAP-PCR", ",", "as", "a", "first", "step", ",", "is", "a", "quick", "and", "sensitive", "method", "for", "the", "identification", "and", "isolation", "of", "novel", "C0017337#ent", "<e1>", "expressed", "in", "C1826313#ent", "<e2>", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C1826313", "name": "C1826313#ent", "pos": [29, 30]}}
{"token": ["Since", "PKC", "betaII", "requires", "Ca(2+)", "glucose", "is", "C0027867#ent", "<e1>", ",", "we", "have", "investigated", "whether", "C0271650#ent", "<e2>", "regulated", "by", "the", "entry", "of", "dietary", "Ca(2", "+", ")", "through", "Ca(v)1.3", "in", "the", "apical", "membrane"], "h": {"id": "C0027867", "name": "C0027867#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0271650", "name": "C0271650#ent", "pos": [14, 15]}}
{"token": ["Basal", "stem", "infection", "with", "H.", "annosum", "resulted", "in", "D.", "pinea", "causing", "longer", "necrotic", "lesions", "the", "shoots", ",", "indicating", "systemic", "induced", "susceptibility", "(", "C1705597#ent", "<e1>", ")", "to", "this", "shoot", "C0275586#ent", "<e2>", "pathogen", "."], "h": {"id": "C1705597", "name": "C1705597#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0275586", "name": "C0275586#ent", "pos": [28, 29]}}
{"token": ["C0694872#ent", "<e1>", "signaling", "increased", "C1415653#ent", "<e2>", "expression", "through", "Rac1", "."], "h": {"id": "C0694872", "name": "C0694872#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1415653", "name": "C1415653#ent", "pos": [4, 5]}}
{"token": ["F80", "contained", "the", "C0017346#ent", "<e1>", "determinants", "of", "C2698947#ent", "<e2>", "but", "did", "not", "react", "with", "Abelson-specific", "serum", "."], "h": {"id": "C0017346", "name": "C0017346#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2698947", "name": "C2698947#ent", "pos": [7, 8]}}
{"token": ["Greater", "understanding", "of", "the", "pathogenesis", "of", "the", "C0022658#ent", "<e1>", "lead", "to", "treatments", "which", "will", "forestall", "the", "development", "of", "C0078911#ent", "<e2>", "and", "possibly", "other", "forms", "of", "fibrotic", "renal", "disease"], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0078911", "name": "C0078911#ent", "pos": [18, 19]}}
{"token": ["We", "examined", "the", "C1517495#ent", "<e1>", "a", "global", "sample", "A.", "sydowii", ",", "including", "isolates", "from", "C0012634#ent", "<e2>", "corals", ",", "C0012634#ent", "<e2>", "humans", ",", "and", "environmental", "sources"], "h": {"id": "C1517495", "name": "C1517495#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0012634", "name": "C0012634#ent", "pos": [14, 15]}}
{"token": ["Cyclooxygenase-2", "(", "COX-2", ")", "is", "an", "C1705964#ent", "<e1>", "gene", "induced", "in", "renal", "mesangial", "cells", "C0534519#ent", "<e2>", "(", "IL-1beta", ")", "."], "h": {"id": "C1705964", "name": "C1705964#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0534519", "name": "C0534519#ent", "pos": [14, 15]}}
{"token": ["First", ",", "the", "concentration", "of", "free", "C1413043#ent", "<e1>", "+", "required", "for", "the", "maximum", "activation", "of", "C1428074#ent", "<e2>", "two", "to", "three", "orders", "of", "magnitude", "greater", "than", "the", "concentration", "required", "by", "typical", "calmodulin-dependent", "enzymes"], "h": {"id": "C1413043", "name": "C1413043#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1428074", "name": "C1428074#ent", "pos": [15, 16]}}
{"token": ["C1707866#ent", "<e1>", "in", "the", "yeast", "Saccharomyces", "cerevisiae", "the", "counterpart", "of", "the", "human", "C0009207#ent", "<e2>", "group", "B", "CSB", ")", "gene", "."], "h": {"id": "C1707866", "name": "C1707866#ent", "pos": [0, 1]}, "relation": "gene_associated_with_disease", "t": {"id": "C0009207", "name": "C0009207#ent", "pos": [12, 13]}}
{"token": ["Cerebral", "tuberculosis", "tuberculosis", "of", "the", "brain", "manifests", "predominantly", "as", "tuberculous", "meningitis", "by", "C0085388#ent", "<e1>", ",", "tuberculous", "abscess", "and", "other", "concomitant", "forms", "such", "as", "C0041321#ent", "<e2>", "tuberculous", "encephalopathy", "tuberculous", "encephalitis", "and", "tuberculous", "arteritis"], "h": {"id": "C0085388", "name": "C0085388#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0041321", "name": "C0041321#ent", "pos": [23, 24]}}
{"token": ["C0007804#ent", "<e1>", "also", "inhibited", "PGD2", "release", "in", "insensitive", "C0004096#ent", "<e2>", "patients", "but", "not", "in", "both", "sensitive", "patients", "and", "healthy", "subjects"], "h": {"id": "C0007804", "name": "C0007804#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004096", "name": "C0004096#ent", "pos": [8, 9]}}
{"token": ["We", "report", "three", "patients", "with", "C0338451#ent", "<e1>", "that", "developed", "C0242422#ent", "<e2>", "and", "prominent", "antecollis", "after", "treatment", "with", "newer", "antipsychotics", ",", "including", "olanzapine", ",", "risperidone", "and", "quetiapine", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [5, 6]}, "relation": "has_manifestation", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [9, 10]}}
{"token": ["C0030326#ent", "<e1>", "known", "as", "C0023787#ent", "<e2>", "is", "an", "inflammatory", "condition", "adipose", "tissue"], "h": {"id": "C0030326", "name": "C0030326#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023787", "name": "C0023787#ent", "pos": [4, 5]}}
{"token": ["Recently", "C0033497#ent", "<e1>", "was", "found", "to", "inhibit", "human", "lecithin", ":", "cholesterol", "acyl", "transferase", "C1416804#ent", "<e2>", ")", "activity", "both", "after", "oral", "treatment", "after", "addition", "to", "plasma", "in", "vitro"], "h": {"id": "C0033497", "name": "C0033497#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416804", "name": "C1416804#ent", "pos": [13, 14]}}
{"token": ["Although", "MCF-7", "cells", "to", "C2936882#ent", "<e1>", "by", "inducing", "the", "C0812312#ent", "<e2>", "c-Fos", "and", "c-Jun", ",", "HaCaT", "cells", "expressing", "estrogen", "receptor", "not", "."], "h": {"id": "C2936882", "name": "C2936882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812312", "name": "C0812312#ent", "pos": [9, 10]}}
{"token": ["Bromocriptine", "(", "intravenous", "and", "intraluminal", ")", "stimulated", "ileal", "and", "colonic", "water", "absorption", "which", "was", "inhibited", "by", "haloperidol", "and", "C0724441#ent", "<e1>", ",", "and", "reversed", "C0008354#ent", "<e2>", "toxin-induced", "ileal", "secretion", "."], "h": {"id": "C0724441", "name": "C0724441#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0008354", "name": "C0008354#ent", "pos": [23, 24]}}
{"token": ["This", "led", "to", "the", "identification", "of", "phosphorylation", "sites", "in", "the", "carboxyl", "terminus", "the", "minichromosome", "maintenance", "protein", "3", "(", "C1334490#ent", "<e1>", ")", ",", "a", "component", "of", "the", "hexameric", "MCM", "C0920283#ent", "<e2>"], "h": {"id": "C1334490", "name": "C1334490#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0920283", "name": "C0920283#ent", "pos": [28, 29]}}
{"token": ["In", "C0026946#ent", "<e1>", "fungoides", "elevated", "C1415975#ent", "<e2>", "is", "common", ",", "but", "normal", "levels", "are", "found", ",", "too", "."], "h": {"id": "C0026946", "name": "C0026946#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1415975", "name": "C1415975#ent", "pos": [5, 6]}}
{"token": ["We", "have", "identified", "three", "examples", "of", "female", "Wistar", "rats", "the", "tremor", "and", "C0036572#ent", "<e1>", "characteristic", "of", "the", "C0022716#ent", "<e2>", "md", ")", "mutation", ",", "which", "is", "ordinarily", "seen", "only", "in", "males", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [12, 13]}, "relation": "manifestation_of", "t": {"id": "C0022716", "name": "C0022716#ent", "pos": [17, 18]}}
{"token": ["C0065180#ent", "<e1>", "was", "particularly", "effective", "compared", "with", "placebo", "in", "relieving", "C1260880#ent", "<e2>", "sneezing", ",", "and", "itching/burning", "eyes", "."], "h": {"id": "C0065180", "name": "C0065180#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1260880", "name": "C1260880#ent", "pos": [10, 11]}}
{"token": ["Intraperitoneal", "(", "C0021171#ent", "<e1>", ")", "administration", "of", "5", "mg/kg", "C0175697#ent", "<e2>", "to", "CD-1", "mice", "by", "exposure", "to", "ppm", "O3", "for", "1.5", "hr", "produced", "synergistic", "effects", "measured", "by", "pulmonary", "edemagenesis", "lethality", "assays", "."], "h": {"id": "C0021171", "name": "C0021171#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [9, 10]}}
{"token": ["The", "clinical", "severity", "C0030567#ent", "<e1>", "did", "not", "correlate", "significantly", "with", "the", "C1420276#ent", "<e2>", "width", "or", "the", "score", "of", "putaminal", "hypointensity", "in", "MSA", "."], "h": {"id": "C0030567", "name": "C0030567#ent", "pos": [3, 4]}, "relation": "disease_has_associated_gene", "t": {"id": "C1420276", "name": "C1420276#ent", "pos": [11, 12]}}
{"token": ["Uncomplicated", "C0033860#ent", "<e1>", "patients", "had", "higher", "frequencies", "of", "C1417638#ent", "<e2>", ",", "Cw6", "and", "DR7", "than", "patients", "with", "psoriatic", "arthritis", "while", "B7", "and", "B27", "correlated", "with", "development", "of", "arthritis", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1417638", "name": "C1417638#ent", "pos": [8, 9]}}
{"token": ["We", "suggest", "that", "tetracyclines", "should", "be", "avoided", "in", "patients", "with", "C0033860#ent", "<e1>", "and", "in", "healthy", "persons", "a", "genetic", "predisposition", "positive", "family", "history", "human", "leukocyte", "antigens", "B13", "C1417638#ent", "<e2>", ",", "B27", ")", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1417638", "name": "C1417638#ent", "pos": [26, 27]}}
{"token": ["In", "initial", "C0011334#ent", "<e1>", "lesions", "and", "plaque", ",", "concentrated", "C0035064#ent", "<e2>", "form", "globules", "of", "a", "calcium", "fluoride-like", "material", "on", "the", "enamel", "surface"], "h": {"id": "C0011334", "name": "C0011334#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [9, 10]}}
{"token": ["Although", "C1333237#ent", "<e1>", "heterogeneity", "has", "been", "demonstrated", "in", "C3273670#ent", "<e2>", ",", "we", "have", "found", "that", "the", "preferentially", "repaired", "regions", "in", "these", "cells", "do", "not", "include", "the", "essential", "DHFR", "gene"], "h": {"id": "C1333237", "name": "C1333237#ent", "pos": [1, 2]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3273670", "name": "C3273670#ent", "pos": [8, 9]}}
{"token": ["The", "commonest", "rheumatic", "disorder", "osteoarthritis", "which", "accounted", "for", "55", "%", "of", "all", "C0009326#ent", "<e1>", "followed", "by", "C0683381#ent", "<e2>", "16", "%", ")", ",", "and", "osteoporosis", "(", "12", "%", ")", "."], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0683381", "name": "C0683381#ent", "pos": [16, 17]}}
{"token": ["C0340076#ent", "<e1>", "Loeffler's", "syndrome", "induced", "by", "C0010980#ent", "<e2>", "without", "cutaneous", "manifestation", "has", "been", "reported", "in", "a", "non", "leprosy", "patient", "by", "Janier", "et", "al."], "h": {"id": "C0340076", "name": "C0340076#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [6, 7]}}
{"token": ["Comparisons", "with", "the", "previously", "reported", "repository", "drugs", "cycloguanil", "pamoate", "and", "acedapsone", "(", "C0000949#ent", "<e1>", ",", "in", "mice", "demonstrated", "that", "C0034283#ent", "<e2>", "pamoate", "provides", "an", "equal", "or", "greater", "duration", "of", "protection", "."], "h": {"id": "C0000949", "name": "C0000949#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0034283", "name": "C0034283#ent", "pos": [19, 20]}}
{"token": ["The", "aim", "of", "the", "present", "prospective", "masked", "study", "to", "assess", "the", "effect", "of", "bimatoprost", "monotherapy", "on", "ocular", "blood", "flow", "intraocular", "pressure", "IOP", ")", "in", "eyes", "of", "C0017605#ent", "<e1>", "patients", "already", "on", "concomitant", "timolol", "and", "C0770456#ent", "<e2>", "."], "h": {"id": "C0017605", "name": "C0017605#ent", "pos": [26, 27]}, "relation": "may_be_treated_by", "t": {"id": "C0770456", "name": "C0770456#ent", "pos": [34, 35]}}
{"token": ["Here", "we", "show", "by", "combined", "congenic", ",", "linkage", "and", "microarray", "studies", "that", "the", "activator", "protein-1", "AP-1", ")", "transcription", "factor", "C1705887#ent", "<e1>", "is", "a", "major", "determinant", "of", "macrophage", "activity", "is", "associated", "with", "C0156221#ent", "<e2>"], "h": {"id": "C1705887", "name": "C1705887#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [31, 32]}}
{"token": ["In", "earlier", "studies", ",", "we", "reported", "the", "purification", "of", "CL", "synthase", "Saccharomyces", "cerevisiae", "the", "cloning", "of", "the", "gene", "CRD1", "(", "previously", "called", "C1824795#ent", "<e1>", ")", "that", "encodes", "the", "C0014442#ent", "<e2>", "."], "h": {"id": "C1824795", "name": "C1824795#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [28, 29]}}
{"token": ["In", "the", "same", "experimental", "group", "number", "of", "C0064833#ent", "<e1>", "PMNs", ")", "in", "C1704942#ent", "<e2>", "is", "elevated", "significantly", "on", "days", "1", "and", "3", "."], "h": {"id": "C0064833", "name": "C0064833#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1704942", "name": "C1704942#ent", "pos": [12, 13]}}
{"token": ["C0221002#ent", "<e1>", "HPT", ")", "in", "multiple", "endocrine", "neoplasia", "type", "1", "MEN1", ")", "patients", "with", "C0043515#ent", "<e2>", "ZES", ")", "is", "caused", "by", "parathyroid", "hyperplasia"], "h": {"id": "C0221002", "name": "C0221002#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [14, 15]}}
{"token": ["The", "patient", "remained", "C0028961#ent", "<e1>", "in", "the", "postoperative", "period", "and", "received", "additionally", "600", "ml", "C0024730#ent", "<e2>", "intravenously", "for", "osmodiuresis", "within", "a", "period", "of", "6", "days", "."], "h": {"id": "C0028961", "name": "C0028961#ent", "pos": [3, 4]}, "relation": "may_be_treated_by", "t": {"id": "C0024730", "name": "C0024730#ent", "pos": [14, 15]}}
{"token": ["C0010583#ent", "<e1>", "inhibited", "the", "mOscp1-mediated", "C3203102#ent", "<e2>", "uptake", "."], "h": {"id": "C0010583", "name": "C0010583#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3203102", "name": "C3203102#ent", "pos": [5, 6]}}
{"token": ["One", "of", "the", "returning", "travelers", "also", "acquired", "C0040896#ent", "<e1>", "and", "another", "C0013370#ent", "<e2>", "."], "h": {"id": "C0040896", "name": "C0040896#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0013370", "name": "C0013370#ent", "pos": [11, 12]}}
{"token": ["Moreover", ",", "the", "expression", "of", "C2698415#ent", "<e1>", "was", "considerably", "reduced", "in", "tobacco", "plants", "C3890227#ent", "<e2>", "NtHSP70", "-", "1", "."], "h": {"id": "C2698415", "name": "C2698415#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3890227", "name": "C3890227#ent", "pos": [13, 14]}}
{"token": ["C1334877#ent", "<e1>", ")", ",", "which", "prevents", "p65", "nuclear", "translocation", "inhibited", "AEG-1-induced", "enhanced", "C0026818#ent", "<e2>", "cloning", "efficiency", "and", "increased", "matrigel", "invasion", "of", "HeLa", "cells"], "h": {"id": "C1334877", "name": "C1334877#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026818", "name": "C0026818#ent", "pos": [12, 13]}}
{"token": ["One", "hundred", "forty", "three", "eyes", "of", "seventy-two", "patients", "divided", "in", "four", "subgroups", "normal", ",", "low-tension", "glaucoma", "C1420817#ent", "<e1>", ")", ",", "primary", "open", "angle", "glaucoma", "POAG", ")", "and", "C0597128#ent", "<e2>", "OH", ")", "."], "h": {"id": "C1420817", "name": "C1420817#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0597128", "name": "C0597128#ent", "pos": [27, 28]}}
{"token": ["C1099413#ent", "<e1>", "CTL2", ")", "is", "a", "C0021699#ent", "<e2>", "expressed", "on", "inner", "ear", "cells", "that", "was", "discovered", "as", "a", "target", "of", "antibody-induced", "hearing", "loss", "."], "h": {"id": "C1099413", "name": "C1099413#ent", "pos": [0, 1]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [6, 7]}}
{"token": ["The", "genome", "of", "feline", "herpesvirus", "type", "1", "FHV-1", ")", ",", "the", "major", "cause", "of", "C0035242#ent", "<e1>", "cats", ",", "contains", "several", "C0017337#ent", "<e2>", "encoding", "homologues", "of", "herpes", "simplex", "virus", "type", "1", "HSV-1", ")", "glycoproteins", "."], "h": {"id": "C0035242", "name": "C0035242#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [20, 21]}}
{"token": ["Thus", ",", "HPP", "subjects", ",", "who", "have", "the", "most", "severe", "C1387532#ent", "<e1>", "have", "the", "highest", "percentage", "of", "C3273505#ent", "<e2>", "as", "well", "as", "a", "decreased", "spectrin", "content", "."], "h": {"id": "C1387532", "name": "C1387532#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3273505", "name": "C3273505#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "the", "autosomal", "recessive", "type", "of", "JP", "AR-JP", ")", "was", "confirmed", "to", "be", "a", "C0029896#ent", "<e1>", "the", "detection", "of", "an", "abnormality", "of", "the", "'", "C2983548#ent", "<e2>"], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C2983548", "name": "C2983548#ent", "pos": [25, 26]}}
{"token": ["Its", "inotropic", "mechanism", "based", "on", "calcium", "sensitisation", "of", "myofilaments", "and", "its", "C0042402#ent", "<e1>", "actions", "are", "related", "to", "the", "opening", "of", "C0059946#ent", "<e2>", "K-channels", "in", "the", "vasculature", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0059946", "name": "C0059946#ent", "pos": [20, 21]}}
{"token": ["Src", "homology", "3", "domains", "several", "C0038085#ent", "<e1>", "including", "Lck", ",", "C1442788#ent", "<e2>", ",", "Abl", ",", "and", "Src", "associate", "with", "ADAM15", "in", "vitro"], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1442788", "name": "C1442788#ent", "pos": [10, 11]}}
{"token": ["Therefore", ",", "the", "C1425141#ent", "<e1>", "promoter", "appears", "to", "function", "C0907533#ent", "<e2>", ",", "and", "we", "conclude", "that", "distant", "elements", "regulate", "the", "tissue-selective", "expression", "of", "this", "gene", "."], "h": {"id": "C1425141", "name": "C1425141#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [9, 10]}}
{"token": ["The", "intravenous", "glycoprotein", "IIb/IIIa", "antagonists", "abciximab", "tirofiban", "and", "C0253563#ent", "<e1>", "are", "well", "accepted", "for", "the", "therapy", "of", "patients", "with", "C0002965#ent", "<e2>", "as", "concomitant", "medication", "during", "coronary", "interventions"], "h": {"id": "C0253563", "name": "C0253563#ent", "pos": [8, 9]}, "relation": "may_treat", "t": {"id": "C0002965", "name": "C0002965#ent", "pos": [19, 20]}}
{"token": ["The", "induction", "of", "STC2", "expression", "by", "E(2)", "C0002893#ent", "<e1>", "occurs", "at", "the", "transcriptional", "level", "through", "C1823488#ent", "<e2>"], "h": {"id": "C0002893", "name": "C0002893#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1823488", "name": "C1823488#ent", "pos": [15, 16]}}
{"token": ["Chronic", "periodontitis", "a", "C0029400#ent", "<e1>", "with", "unbalanced", "production", "between", "matrix", "metalloproteinases", "C0623362#ent", "<e2>", ")", ",", "such", "as", "interstitial", "collagenase", "MMP-1", ")", "and", "stromelysin-1", "(", "MMP-3", ")", "and", "their", "endogenous", "tissue", "inhibitors", "C0623362#ent", "<e2>", "(", "TIMPs", ")", "."], "h": {"id": "C0029400", "name": "C0029400#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0623362", "name": "C0623362#ent", "pos": [11, 12]}}
{"token": ["Participants", "were", "grouped", "as", "no", "atopic", "dermatitis", "C3811116#ent", "<e1>", "or", "in", "quartiles", "of", "increasing", "severity", "of", "C0011615#ent", "<e2>", "Gps", "1", "-", "4", ")", "quantified", "by", "days", "of", "topical", "steroid", "as", "reported", "monthly", "."], "h": {"id": "C3811116", "name": "C3811116#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0011615", "name": "C0011615#ent", "pos": [16, 17]}}
{"token": ["Forty-nine", "patients", "admitted", "to", "a", "Coronary", "Care", "Unit", "myocardial", "infarction", "by", "C0023212#ent", "<e1>", "were", "treated", "with", "mg", "C0699988#ent", "<e2>", "over", "36", "hours", "."], "h": {"id": "C0023212", "name": "C0023212#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0699988", "name": "C0699988#ent", "pos": [17, 18]}}
{"token": ["A", "patient", "with", "C0019880#ent", "<e1>", "presenting", "with", "fatal", "cerebral", "infarction", "resulted", "from", "C0265101#ent", "<e2>", "reported", "."], "h": {"id": "C0019880", "name": "C0019880#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0265101", "name": "C0265101#ent", "pos": [12, 13]}}
{"token": ["Many", "kinds", "of", "natural", "products", "such", "as", "terpenoids", ",", "alkaloids", ",", "flavonoids", ",", "C0359916#ent", "<e1>", ",", "and", "some", "others", ",", "have", "shown", "C0935929#ent", "<e2>"], "h": {"id": "C0359916", "name": "C0359916#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0935929", "name": "C0935929#ent", "pos": [22, 23]}}
{"token": ["The", "abnormalities", "found", "in", "the", "C0009326#ent", "<e1>", "with", "many", "C0004364#ent", "<e2>", "other", "inflammatory", "states"], "h": {"id": "C0009326", "name": "C0009326#ent", "pos": [5, 6]}, "relation": "has_nichd_parent", "t": {"id": "C0004364", "name": "C0004364#ent", "pos": [9, 10]}}
{"token": ["To", "determine", "the", "signaling", "mechanisms", "of", "C1424252#ent", "<e1>", ",", "we", "investigated", "activation", "of", "mitogen-activated", "protein", "MAP", ")", "C0010536#ent", "<e2>", "induced", "by", "C1424252#ent", "<e1>", "."], "h": {"id": "C0010536", "name": "C0010536#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1424252", "name": "C1424252#ent", "pos": [6, 7]}}
{"token": ["Further", "analysis", "shows", "that", ",", "with", "the", "exception", "of", "biglycan", ",", "all", "known", "C2338738#ent", "<e1>", "genes", "reside", "in", "three", "C0017258#ent", "<e2>"], "h": {"id": "C2338738", "name": "C2338738#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0017258", "name": "C0017258#ent", "pos": [19, 20]}}
{"token": ["After", "20", "min", "C0007785#ent", "<e1>", "pial", "arterioles", "not", "dilate", "to", "hypercapnia", "but", "responded", "to", "C0022245#ent", "<e2>", "in", "a", "fashion", "similar", "to", "before", "ischemia", "."], "h": {"id": "C0007785", "name": "C0007785#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022245", "name": "C0022245#ent", "pos": [14, 15]}}
{"token": ["This", "study", "compared", "the", "evolution", "of", "patients", "with", "C1539521#ent", "<e1>", "treated", "with", "macrolides", "and", "C3540047#ent", "<e2>", "."], "h": {"id": "C1539521", "name": "C1539521#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C3540047", "name": "C3540047#ent", "pos": [14, 15]}}
{"token": ["We", "tested", "this", "hypothesis", "by", "electron", "microscopic", "examination", "DRN", "sections", "dually", "labeled", "C0086140#ent", "<e1>", "anterogradely", "transported", "from", "the", "PFC", "and", "immunogold-silver", "labeling", "for", "C1420870#ent", "<e2>", "TrH", ")", "or", "for", "GABA", "."], "h": {"id": "C0086140", "name": "C0086140#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1420870", "name": "C1420870#ent", "pos": [23, 24]}}
{"token": ["Suppression", "of", "C2829145#ent", "<e1>", "by", "short", "interfering", "RNA", "leads", "to", "a", "marked", "reduction", "in", "C1705791#ent", "<e2>", "activity", "when", "cells", "are", "stimulated", "with", "serum", "."], "h": {"id": "C2829145", "name": "C2829145#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [14, 15]}}
{"token": ["The", "altered", "receptors", "were", "transfected", "into", "a", "mutant", "subline", "of", "PC12", "rat", "pheochromocytoma", "cells", "designated", "PC12nnr5", ")", "that", ",", "unlike", "C2987364#ent", "<e1>", "PC12", "cells", "lack", "expression", "of", "endogenous", "C3273659#ent", "<e2>", "and", "responsiveness", "to", "NGF", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C3273659", "name": "C3273659#ent", "pos": [28, 29]}}
{"token": ["Cystic", "kidneys", "C0376515#ent", "<e1>", "-/-", "mice", "exhibited", "sustained", "phosphorylation", "of", "Src", "and", "mitogen-activated", "protein", "kinase/extracellular", "signal-regulated", "kinase", "C1334474#ent", "<e2>", ",", "ERK1", ")", "."], "h": {"id": "C0376515", "name": "C0376515#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334474", "name": "C1334474#ent", "pos": [17, 18]}}
{"token": ["Nimesulide", ",", "meclofenamate", ",", "and", "C0031990#ent", "<e1>", "were", "more", "selective", "towards", "SULT1A1", "inhibition", ",", "while", "C0038792#ent", "<e2>", "and", "ibuprofen", "were", "more", "selective", "towards", "SULT1E1", "inhibition", "."], "h": {"id": "C0031990", "name": "C0031990#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0038792", "name": "C0038792#ent", "pos": [15, 16]}}
{"token": ["The", "tyrosine", "kinase", "blockers", "genistein", "and", "C0256167#ent", "<e1>", "significant", "concentration-dependent", "inhibitions", "of", "C2239920#ent", "<e2>", "increases", "due", "to", "vitronectin", "and", "zymosan-activated", "serum", "."], "h": {"id": "C0256167", "name": "C0256167#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2239920", "name": "C2239920#ent", "pos": [12, 13]}}
{"token": ["Finally", ",", "mouse", "embryo", "fibroblasts", "deficient", "in", "C1335281#ent", "<e1>", "displayed", "subtle", "changes", "in", "tyrosine", "phosphorylation", "including", "hyperphosphorylation", "of", "C0169661#ent", "<e2>", "."], "h": {"id": "C1335281", "name": "C1335281#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0169661", "name": "C0169661#ent", "pos": [18, 19]}}
{"token": ["Laminin", ",", "a", "major", "C0072522#ent", "<e1>", "component", "of", "C0148346#ent", "<e2>", "basement", "membranes", "is", "recognized", "by", "beta1-", "and", "beta3-integrins", "expressed", "on", "endothelial", "cells"], "h": {"id": "C0072522", "name": "C0072522#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0148346", "name": "C0148346#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "we", "demonstrated", "that", "endogenous", "C1417830#ent", "<e1>", "is", "phosphorylated", "upon", "simulation", "of", "RAW", "264.7", "cells", "with", "C0175697#ent", "<e2>", "."], "h": {"id": "C1417830", "name": "C1417830#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [17, 18]}}
{"token": ["The", "order", "of", "potency", "was", ":", "C0032912#ent", "<e1>", "greater", "than", "WB4101", "=", "C1569495#ent", "<e2>", "greater", "than", "tiodazosin", "greater", "than", "phentolamine", "greater", "than", "corynanthine", "greater", "than", "trimazosin", "greater", "than", "rauwolscine", "."], "h": {"id": "C0032912", "name": "C0032912#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1569495", "name": "C1569495#ent", "pos": [12, 13]}}
{"token": ["Taxol", ",", "a", "plant", "alkaloid", "promise", "as", "an", "C0003392#ent", "<e1>", "produced", "a", "predominantly", "C0699739#ent", "<e2>", "16", "of", "60", "patients", "treated", "in", "two", "phase", "I", "trials"], "h": {"id": "C0003392", "name": "C0003392#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0699739", "name": "C0699739#ent", "pos": [13, 14]}}
{"token": ["This", "gene", "is", "identical", "to", "C1701412#ent", "<e1>", ",", "encoding", "a", "C1333949#ent", "<e2>", "required", "for", "DNA", "replication"], "h": {"id": "C1701412", "name": "C1701412#ent", "pos": [5, 6]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333949", "name": "C1333949#ent", "pos": [10, 11]}}
{"token": ["This", "study", "describes", "the", "frequency", "of", "sonographically", "detected", "C0015929#ent", "<e1>", "the", "correlation", "of", "C2317073#ent", "<e2>", "RPD", ")", "with", "the", "need", "for", "postnatal", "surgery", "and", "proposed", "management", "of", "RPD", "."], "h": {"id": "C0015929", "name": "C0015929#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2317073", "name": "C2317073#ent", "pos": [13, 14]}}
{"token": ["C0125988#ent", "<e1>", "represents", "a", "cost-effective", "approach", "to", "the", "management", "of", "C0026838#ent", "<e2>", "primarily", "because", "of", "the", "rapid", "symptomatic", "relief", "that", "it", "provides", "."], "h": {"id": "C0125988", "name": "C0125988#ent", "pos": [0, 1]}, "relation": "may_treat", "t": {"id": "C0026838", "name": "C0026838#ent", "pos": [10, 11]}}
{"token": ["C0013065#ent", "<e1>", "in", "overdose", "seems", "to", "be", "C0003286#ent", "<e2>", "."], "h": {"id": "C0013065", "name": "C0013065#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003286", "name": "C0003286#ent", "pos": [7, 8]}}
{"token": ["The", "differential", "diagnosis", "C0015967#ent", "<e1>", "patients", "with", "a", "C0015230#ent", "<e2>", "is", "extensive", "."], "h": {"id": "C0015967", "name": "C0015967#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0015230", "name": "C0015230#ent", "pos": [8, 9]}}
{"token": ["In", "the", "sc", "implanted", "human", "prostate", "tumors", "22Rv-1", ")", "in", "nude", "mice", "AN-7", "significantly", "inhibited", "Ki-67", ",", "HIF-1alpha", ",", "HER-2/neu", ",", "C1522505#ent", "<e1>", "and", "increased", "C1430988#ent", "<e2>", "level", "."], "h": {"id": "C1522505", "name": "C1522505#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1430988", "name": "C1430988#ent", "pos": [25, 26]}}
{"token": ["Analysis", "of", "the", "C0678928#ent", "<e1>", "PIG-A", "from", "haemopoietic", "cells", "a", "female", "C3889380#ent", "<e2>", "patient", "showed", "a", "homozygous", "C-55-T", "substitution", "that", "caused", "replacement", "of", "arginine", "with", "tryptophan", "at", "codon", "19"], "h": {"id": "C0678928", "name": "C0678928#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3889380", "name": "C3889380#ent", "pos": [11, 12]}}
{"token": ["Some", "recent", "studies", "found", "that", "C2827469#ent", "<e1>", "patients", "have", "a", "C0270612#ent", "<e2>", "cerebellum", "atrophy"], "h": {"id": "C2827469", "name": "C2827469#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0270612", "name": "C0270612#ent", "pos": [10, 11]}}
{"token": ["Chondrocytes", "modulated", "by", "serial", "subcultures", "in", "monolayer", "secreted", "more", "C0699919#ent", "<e1>", "but", "less", "C0162745#ent", "<e2>", "than", "differentiated", "cells", "cultured", "within", "collagen", "gels", "."], "h": {"id": "C0699919", "name": "C0699919#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0162745", "name": "C0162745#ent", "pos": [13, 14]}}
{"token": ["C1824993#ent", "<e1>", "aroused", "worldwide", "enthusiasm", "for", "Visible", "Human", "Research", "(", "C1333258#ent", "<e2>", ")", ",", "and", "the", "data", "set", "being", "used", "in", "a", "variety", "of", "research", "and", "educational", "domains", "."], "h": {"id": "C1824993", "name": "C1824993#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333258", "name": "C1333258#ent", "pos": [10, 11]}}
{"token": ["C2364020#ent", "<e1>", "expression", "of", "Six1", "and", "C3828009#ent", "<e2>", "was", "observed", "with", "mesodermal", "head", "mesenchyme", "somites", "and", "their", "derivatives", ",", "the", "muscle", "anlagen", "of", "the", "embryonic", "trunk"], "h": {"id": "C2364020", "name": "C2364020#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3828009", "name": "C3828009#ent", "pos": [6, 7]}}
{"token": ["In", "contrast", "to", "all", "other", "C0017337#ent", "<e1>", "from", "the", "X-specific", "region", "of", "Xp22.3", ",", "C1418934#ent", "<e2>", "has", "a", "homologue", "on", "Yp", "rather", "than", "Yq", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1418934", "name": "C1418934#ent", "pos": [14, 15]}}
{"token": ["We", "analyzed", "the", "3", "'", "termini", "of", "the", "NNKOAc", "induced", "single-strand", "breaks", "a", "(32)P-post-labeling", "assay", "or", "a", "C1414292#ent", "<e1>", "the", "3'-termini", "catalyzed", "by", "T4", "DNA", "polymerase", "with", "C0057460#ent", "<e2>", "treatment", "."], "h": {"id": "C1414292", "name": "C1414292#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0057460", "name": "C0057460#ent", "pos": [27, 28]}}
{"token": ["Fasting", "(", "with", "vitamin", "C-supplementation", ")", "and", "C1510471#ent", "<e1>", "guinea-pigs", "are", "associated", "with", "decreased", "C1333079#ent", "<e2>", "expression", "in", "connective", "tissues"], "h": {"id": "C1510471", "name": "C1510471#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1333079", "name": "C1333079#ent", "pos": [14, 15]}}
{"token": ["Muscle", "samples", "analyzed", "for", "ATP", ",", "C0010287#ent", "<e1>", "(", "PCr", ")", ",", "lactate", ",", "and", "H+", ";", "C1428048#ent", "<e2>", "and", "MCT4", "relative", "abundance", "and", "betam(in", "vitro", ")", "were", "also", "determined", "in", "resting", "muscle", "."], "h": {"id": "C0010287", "name": "C0010287#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1428048", "name": "C1428048#ent", "pos": [17, 18]}}
{"token": ["This", "was", "demonstrated", "by", "release", "of", "low", "molecular", "weight", "oligosaccharides", "from", "high", "molecular", "weight", "C0061642#ent", "<e1>", "by", "mild", "base", "hydrolysis", "the", "conversion", "of", "C1414945#ent", "<e2>", "to", "galactosaminitol", "."], "h": {"id": "C0061642", "name": "C0061642#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1414945", "name": "C1414945#ent", "pos": [23, 24]}}
{"token": ["Moreover", ",", "the", "effects", "of", "C0812281#ent", "<e1>", "on", "Topo", "II", "C1528018#ent", "<e2>", "give", "new", "insights", "into", "the", "diverse", "biological", "activities", "C0812281#ent", "<e1>", "."], "h": {"id": "C1528018", "name": "C1528018#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812281", "name": "C0812281#ent", "pos": [5, 6]}}
{"token": ["In", "the", "restraint", "plus", "water-immersion", "stress", "model", "score", "for", "intraluminal", "bleeding", "and", "the", "cumulative", "C0341221#ent", "<e1>", "length", "was", "significantly", "lower", "for", "rats", "treated", "with", "C0700481#ent", "<e2>", "and", "sulpiride", "."], "h": {"id": "C0341221", "name": "C0341221#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0700481", "name": "C0700481#ent", "pos": [24, 25]}}
{"token": ["C0282213#ent", "<e1>", ",", "a", "peripheral", "arteriolar", "vasodilator", "was", "given", "to", "12", "patients", "with", "C0018802#ent", "<e2>"], "h": {"id": "C0282213", "name": "C0282213#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0018802", "name": "C0018802#ent", "pos": [13, 14]}}
{"token": ["The", "NO", "donor", "s-nitroso-n-acetylpenicillamine", ",", "the", "phosphodiesterase", "V", "antagonist", "zaprinast", "C1428222#ent", "<e1>", ")", "and", "PGI2", "each", "potentiated", "C1706383#ent", "<e2>", "messenger", "RNA", "expression", ",", "an", "index", "of", "initiation", "of", "the", "liver", "regeneration", "cascade", "following", "PHx", "."], "h": {"id": "C1428222", "name": "C1428222#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1706383", "name": "C1706383#ent", "pos": [17, 18]}}
{"token": ["The", "results", "suggest", "a", "potential", "role", "for", "progesterone", "in", "regulating", "C0022860#ent", "<e1>", "elimination", "by", "modulating", "the", "expression", "of", "C0537026#ent", "<e2>", ",", "leading", "to", "enhanced", "drug", "metabolism", "pregnancy", "."], "h": {"id": "C0022860", "name": "C0022860#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0537026", "name": "C0537026#ent", "pos": [18, 19]}}
{"token": ["We", "hypothesize", "that", "the", "observed", "effects", "of", "C0301336#ent", "<e1>", "salicylamide", "are", "due", "to", "their", "C0359916#ent", "<e2>", "character", "mediating", "a", "molecular", "hydrophobicity", "."], "h": {"id": "C0301336", "name": "C0301336#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0359916", "name": "C0359916#ent", "pos": [14, 15]}}
{"token": ["Therefore", ",", "C0011816#ent", "<e1>", "may", "activate", "some", "factors", "that", "inhibit", "negative", "action", "of", "C1419771#ent", "<e2>", "on", "DMP1", "expression", "."], "h": {"id": "C0011816", "name": "C0011816#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1419771", "name": "C1419771#ent", "pos": [13, 14]}}
{"token": ["Since", "C0812303#ent", "<e1>", ",", "one", "of", "C0919476#ent", "<e2>", "tyrosine++", "kinase", "function", ",", "is", "co-precipitated", "with", "TCR-CD3", "complex", "C0812303#ent", "<e1>", "seems", "to", "be", "involved", "in", "early", "phosphorylation", "for", "T", "cell", "."], "h": {"id": "C0812303", "name": "C0812303#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0919476", "name": "C0919476#ent", "pos": [6, 7]}}
{"token": ["C0729531#ent", "<e1>", "been", "associated", "with", "invasive", "meningococcal", "diseases", "they", "may", "contribute", "to", "these", "C3494361#ent", "<e2>", "symptoms", "."], "h": {"id": "C0729531", "name": "C0729531#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3494361", "name": "C3494361#ent", "pos": [13, 14]}}
{"token": ["Partial", "characterization", "of", "the", "Boc-Val-Pro-Arg-MCA", "C0033993#ent", "<e1>", "activity", "with", "diisopropyl", "fluorophosphate", "that", "the", "proteolytic", "activity", "a", "C2717971#ent", "<e2>"], "h": {"id": "C0033993", "name": "C0033993#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2717971", "name": "C2717971#ent", "pos": [16, 17]}}
{"token": ["Both", "C/EBPbeta", "and", "the", "co-activator", "C1705458#ent", "<e1>", "are", "recruited", "to", "c-fos", "in", "response", "to", "GH", ",", "C2712370#ent", "<e2>", "c-fos", "promoter", "activation", "."], "h": {"id": "C1705458", "name": "C1705458#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2712370", "name": "C2712370#ent", "pos": [16, 17]}}
{"token": ["Phorbol", "12-myristate", "13-acetate", "induced", "HEF1", "tyrosine", "phosphorylation", ",", "and", "the", "protein", "kinase", "C", "inhibitor", "C0054537#ent", "<e1>", "inhibited", "both", "calcitonin-", "and", "phorbol", "12-myristate", "13-acetate-stimulated", "C2348445#ent", "<e2>", "phosphorylation", "."], "h": {"id": "C0054537", "name": "C0054537#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2348445", "name": "C2348445#ent", "pos": [23, 24]}}
{"token": ["Glucose-induced", "accumulation", "of", "two", "hepatic", "gene", "mRNAs", "(", "C3889451#ent", "<e1>", "and", "C1418610#ent", "<e2>", "was", "specifically", "inhibited", "in", "cells", "transfected", "with", "the", "C3889451#ent", "<e1>", "loop", "and", "not", "with", "the", "GLUT2", "C", "terminus"], "h": {"id": "C1418610", "name": "C1418610#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3889451", "name": "C3889451#ent", "pos": [8, 9]}}
{"token": ["Energy", "balance", "not", "affect", "expression", "of", "C1335808#ent", "<e1>", "on", "any", "other", "cell", "types", "expression", "of", "CD11b", "or", "C3889161#ent", "<e2>", "."], "h": {"id": "C1335808", "name": "C1335808#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3889161", "name": "C3889161#ent", "pos": [17, 18]}}
{"token": ["Clozapine", "inhibited", "rotation", "induced", "by", "SK", "&", "F", "38393", ",", "C0003596#ent", "<e1>", "or", "N", ",", "N", "dipropyl", "A-5,6", "C1414176#ent", "<e2>", "but", "failed", "to", "inhibit", "stereotypy", "."], "h": {"id": "C0003596", "name": "C0003596#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1414176", "name": "C1414176#ent", "pos": [18, 19]}}
{"token": ["In", "two", "patients", "with", "C0002895#ent", "<e1>", "one", "hemoglobin", "SC", "one", "C0002895#ent", "<e1>", ",", "central", "retinal", "artery", "occlusions", "."], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [4, 5]}}
{"token": ["Recently", ",", "we", "showed", "that", "polymer", "formation", "correlated", "with", "the", "severity", "of", "hemolysis", "for", "12", "C0002895#ent", "<e1>", "from", "sickle", "trait", "to", "C0002895#ent", "<e1>", "African", ")", "disease", "."], "h": {"id": "C0002895", "name": "C0002895#ent", "pos": [15, 16]}, "relation": "manifestation_of", "t": {"id": "C0002895", "name": "C0002895#ent", "pos": [15, 16]}}
{"token": ["We", "isolated", "the", "complete", "cDNAs", "of", "two", "rab", "isoforms", "rab27a", "and", "rab27b", ",", "from", "human", "melanoma", "cells", "melanocytes", ",", "C1419195#ent", "<e1>", "is", "the", "human", "homolog", "of", "a", "rat", "megakaryocyte", "rab", "C1413285#ent", "<e2>"], "h": {"id": "C1419195", "name": "C1419195#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C1413285", "name": "C1413285#ent", "pos": [30, 31]}}
{"token": ["In", "cultured", "pineals", ",", "the", "serine/threonine", "phosphatase", "type", "1", "type", "2A", "inhibitors", "okadaic", "acid", "calyculin", "A", "significantly", "decreased", "C0001637#ent", "<e1>", "or", "cAMP-induced", "AA-NAT", "activity", ",", "whereas", "the", "C0084210#ent", "<e2>", "cypermethrin", "and", "tyrosine", "phosphatase", "dephostatin", "were", "ineffective", "."], "h": {"id": "C0001637", "name": "C0001637#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0084210", "name": "C0084210#ent", "pos": [27, 28]}}
{"token": ["In", "contrast", ",", "interleukin-1beta", "significantly", "impaired", "prostaglandin", "C2987147#ent", "<e1>", "cAMP", "accumulation", "by", "induction", "of", "C0033551#ent", "<e2>", ",", "prostaglandin", "E2", "production", ",", "and", "a", "resulting", "down-regulation", "of", "adenylyl", "cyclase"], "h": {"id": "C2987147", "name": "C2987147#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033551", "name": "C0033551#ent", "pos": [14, 15]}}
{"token": ["Another", "important", "human", "pharmacological", "implication", "is", "based", "on", "our", "recent", "observation", "that", "monoamine", "uptake", "C0003289#ent", "<e1>", "able", "to", "inhibit", "presynaptic", "C1839729#ent", "<e2>", "in", "the", "enteric", "nervous", "system"], "h": {"id": "C0003289", "name": "C0003289#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1839729", "name": "C1839729#ent", "pos": [20, 21]}}
{"token": ["Calculation", "of", "the", "apparent", "digestibility", "of", "C2827389#ent", "<e1>", "indicated", "that", "C0225326#ent", "<e2>", "may", "have", "provided", "ME", "in", "the", "form", "of", "short-chain", "fatty", "acids", "the", "low", "as", "well", "as", "during", "the", "high", "C0225326#ent", "<e2>", "intake", "."], "h": {"id": "C2827389", "name": "C2827389#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0225326", "name": "C0225326#ent", "pos": [10, 11]}}
{"token": ["Although", "we", "need", "further", "study", "of", "chemotherapeutic", "effect", "in", "vivo", "these", "results", "raise", "the", "possibility", "that", "C1413095#ent", "<e1>", "might", "be", "a", "suitable", "C0003392#ent", "<e2>", "treatment", "of", "osteosarcoma", "."], "h": {"id": "C1413095", "name": "C1413095#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [22, 23]}}
{"token": ["We", "studied", "the", "possible", "changes", "in", "expression", "level", "of", "abundant", "mitochondrial", "chaperon", "C1415782#ent", "<e1>", "and", "main", "human", "cytochrome", "P450", "monooxygenase", "C0010763#ent", "<e2>", "isoform", ")", "at", "dilated", "cardiomyopathy", "DCM", ")", "progression", "at", "the", "end", "stage", "heart", "failure", "Western", "blot", "analysis"], "h": {"id": "C1415782", "name": "C1415782#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0010763", "name": "C0010763#ent", "pos": [20, 21]}}
{"token": ["C1513327#ent", "<e1>", "such", "as", "C0032478#ent", "<e2>", "suppress", "cell", "death", "suggesting", "that", "insertion", "of", "a", "pore", "by", "Shigella", "into", "the", "host", "cell", "membrane", "the", "necrosis", "."], "h": {"id": "C1513327", "name": "C1513327#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032478", "name": "C0032478#ent", "pos": [4, 5]}}
{"token": ["Both", "noradrenaline", "and", "carbachol", "increased", "the", "basal", "level", "of", "IP3", ",", "C2697645#ent", "<e1>", "and", "IP", "by", "the", "activation", "of", "C0178469#ent", "<e2>", "muscarinic", "receptors", "respectively", "."], "h": {"id": "C2697645", "name": "C2697645#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0178469", "name": "C0178469#ent", "pos": [19, 20]}}
{"token": ["The", "trial", "was", "designed", "to", "study", "the", "toxicity", "of", "the", "C1254351#ent", "<e1>", "and", "the", "feasibility", "of", "a", "phase", "III", "trial", "the", "combination", "of", "C0059682#ent", "<e2>", "with", "radiotherapy", "for", "treating", "head", "and", "neck", "squamous", "cell", "carcinomas"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0059682", "name": "C0059682#ent", "pos": [23, 24]}}
{"token": ["Immunoprecipitation", "analysis", "that", "C3812730#ent", "<e1>", ",", "KSRP", "and", "C1420731#ent", "<e2>", "bound", "to", "one", "or", "more", "loci", "in", "the", "3'UTR", "."], "h": {"id": "C3812730", "name": "C3812730#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1420731", "name": "C1420731#ent", "pos": [8, 9]}}
{"token": ["C4084825#ent", "<e1>", "AIH", "and", "PBC", "was", "significantly", "more", "abundant", "than", "in", "C0267797#ent", "<e2>", "AH", ",", "2.72+/-2.23", "ng/mg", ",", "n=10", ";", "p<0.05", ")", "."], "h": {"id": "C4084825", "name": "C4084825#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0267797", "name": "C0267797#ent", "pos": [11, 12]}}
{"token": ["Hypercholesterolemia", "and", "C0043325#ent", "<e1>", "are", "known", "complications", "of", "C0742395#ent", "<e2>"], "h": {"id": "C0043325", "name": "C0043325#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0742395", "name": "C0742395#ent", "pos": [8, 9]}}
{"token": ["A", "stable", "cell", "clone", "J12#26", ",", "which", "continuously", "secretes", "large", "amounts", "of", "the", "C0017343#ent", "<e1>", "(", "E", ")", "antigen", "of", "C0014057#ent", "<e2>", "JE", ")", "virus", "(", "J.", "Virol", "."], "h": {"id": "C0017343", "name": "C0017343#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014057", "name": "C0014057#ent", "pos": [20, 21]}}
{"token": ["Other", "parameters", "of", "C1366463#ent", "<e1>", "production", "in", "vitro", "summarized", "briefly", ",", "and", "the", "effects", "of", "C0701303#ent", "<e2>", "are", "shown", "."], "h": {"id": "C1366463", "name": "C1366463#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0701303", "name": "C0701303#ent", "pos": [15, 16]}}
{"token": ["Mass", "spectrometry", "NMR", "analysis", "indicated", "that", "the", "C1418654#ent", "<e1>", "product", "is", "a", "prodigiosin", "derivative", ",", "called", "C0077826#ent", "<e2>", "."], "h": {"id": "C1418654", "name": "C1418654#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0077826", "name": "C0077826#ent", "pos": [16, 17]}}
{"token": ["DACH1", "inhibited", "induction", "of", "C0162508#ent", "<e1>", "by", "physiological", "stimuli", "repressed", "C1623430#ent", "<e2>", "cyclin", "A", "beta-PAK", ",", "and", "stathmin", ")", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [10, 11]}}
{"token": ["Electrophoretic", "mobility", "shift", "assays", "nuclear", "extracts", "Jurkat", "T", "cells", "well", "as", "TCR/CD3-restimulated", "primary", "human", "T", "cells", "demonstrated", "specific", "binding", "of", "C0162508#ent", "<e1>", ",", "predominantly", "composed", "of", "C1623430#ent", "<e2>", "and", "FosB", ",", "to", "this", "sequence", "."], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [26, 27]}}
{"token": ["Hemorrhagic", "fever", "renal", "syndrome", "HFRS", ")", "is", "a", "rodent-borne", "C0043528#ent", "<e1>", "by", "fever", ",", "hemorrhagic", "manifestations", ",", "and", "C0022658#ent", "<e2>"], "h": {"id": "C0043528", "name": "C0043528#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0022658", "name": "C0022658#ent", "pos": [18, 19]}}
{"token": ["Simultaneous", "hemodynamic", ",", "ventilation", "and", "blood", "gas", "measurements", "were", "performed", "in", "19", "males", "during", "cardiac", "catheterization", "evaluation", "of", "C1412041#ent", "<e1>", "and", "3", "to", "5", "min", "after", "0.4", "mg", "sublingual", "C0885378#ent", "<e2>", "."], "h": {"id": "C1412041", "name": "C1412041#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0885378", "name": "C0885378#ent", "pos": [29, 30]}}
{"token": ["In", "vitro", "exposure", "to", "recombinant", "IL-1", "beta", "increased", "(", "usually", "10", "to", "15-fold", ")", "C3890200#ent", "<e1>", "production", "by", "C1424628#ent", "<e2>", "."], "h": {"id": "C3890200", "name": "C3890200#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1424628", "name": "C1424628#ent", "pos": [18, 19]}}
{"token": ["About", "10", "%", "of", "C0085648#ent", "<e1>", "neurons", "and", "38", "%", "of", "petrosal", "ganglion", "neurons", "contained", "C0919487#ent", "<e2>", "mRNA", "."], "h": {"id": "C0085648", "name": "C0085648#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0919487", "name": "C0919487#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "a", "regimen", "of", "one", "infusion", "weekly", "was", "compared", "with", "that", "of", "two", "(", "C0008533#ent", "<e1>", "or", "three", "(", "C0684275#ent", "<e2>", "infusions", "weekly", "in", "each", "patient", "."], "h": {"id": "C0008533", "name": "C0008533#ent", "pos": [16, 17]}, "relation": "has_nichd_parent", "t": {"id": "C0684275", "name": "C0684275#ent", "pos": [21, 22]}}
{"token": ["Only", "the", "WEHI-279", "and", "BCL1", "lines", "produced", "detectable", "IL-6", "constitutively", ",", "and", "the", "C1706230#ent", "<e1>", "be", "further", "induced", "by", "treatment", "with", "C2697656#ent", "<e2>", "."], "h": {"id": "C1706230", "name": "C1706230#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2697656", "name": "C2697656#ent", "pos": [21, 22]}}
{"token": ["In", "this", "study", ",", "matrix-type", "transdermal", "patches", "containing", "C0012091#ent", "<e1>", "prepared", "using", "different", "ratios", "of", "C0032856#ent", "<e2>", "(", "PVP", ")", "and", "ethylcellulose", "(", "EC", ")", "by", "solvent", "evaporation", "technique", "."], "h": {"id": "C0012091", "name": "C0012091#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0032856", "name": "C0032856#ent", "pos": [15, 16]}}
{"token": ["C0753837#ent", "<e1>", "PLC", "gamma", "1", "and", "p21ras", "guanosine", "triphosphatase", "(", "C1333729#ent", "<e2>", ")", "activating", "protein", "GAP", ")", "bind", "to", "and", "are", "phosphorylated", "by", "activated", "growth", "factor", "receptors"], "h": {"id": "C0753837", "name": "C0753837#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1333729", "name": "C1333729#ent", "pos": [10, 11]}}
{"token": ["The", "efficacy", "of", "metronidazole", "and", "C0040263#ent", "<e1>", "has", "been", "compared", "in", "31", "patients", "with", "C0002438#ent", "<e2>"], "h": {"id": "C0040263", "name": "C0040263#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0002438", "name": "C0002438#ent", "pos": [14, 15]}}
{"token": ["The", "results", "of", "the", "study", "demonstrate", "that", "cAMP", ",", "EGF", ",", "C1524023#ent", "<e1>", "and", "PMA", "stimulate", "C2827383#ent", "<e2>", "p70", "S6", "kinase", "."], "h": {"id": "C1524023", "name": "C1524023#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C2827383", "name": "C2827383#ent", "pos": [16, 17]}}
{"token": ["Bleeding", "times", "are", "also", "prolonged", "by", "C1332027#ent", "<e1>", "antagonism", "with", "prazosin", "or", "C0733398#ent", "<e2>", ",", "by", "specific", "thromboxane", "A2-synthetase", "inhibition", "with", "R", "59", "655", "or", "dazoxiben", ",", "and", "by", "anticoagulant", "treatment", "."], "h": {"id": "C1332027", "name": "C1332027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0733398", "name": "C0733398#ent", "pos": [12, 13]}}
{"token": ["C0056696#ent", "<e1>", "PDEs", ")", "are", "the", "only", "C3540772#ent", "<e2>", "that", "inactivate", "intracellular", "cyclic", "AMP", "cAMP", ")", "."], "h": {"id": "C0056696", "name": "C0056696#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3540772", "name": "C3540772#ent", "pos": [7, 8]}}
{"token": ["The", "results", "of", "both", "phases", "of", "this", "study", "indicate", "that", "the", "specificity", "of", "the", "three", "antigens", "is", "C1538764#ent", "<e1>", "greater", "than", "SP", "greater", "than", "C1424729#ent", "<e2>", "."], "h": {"id": "C1538764", "name": "C1538764#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1424729", "name": "C1424729#ent", "pos": [24, 25]}}
{"token": ["We", "previously", "reported", "that", "in", "the", "female", "rat", "uterus", ",", "the", "levels", "of", "specific", "C3540626#ent", "<e1>", "isoform", "mRNAs", "(", "p40/p45", ")", "were", "increased", "by", "17", "C0014914#ent", "<e2>", "(", "E2", ")", "treatment", "."], "h": {"id": "C3540626", "name": "C3540626#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0014914", "name": "C0014914#ent", "pos": [25, 26]}}
{"token": ["After", "treatment", "of", "the", "patient", "with", "two", "cycles", "of", "chemotherapy", "with", "mechlorethamine", "hydrochloride", "C0042680#ent", "<e1>", "procarbazine", "hydrochloride", "and", "prednisone", ",", "serum", "calcium", "1,25-dihydroxycholecalciferol", ",", "and", "C1705340#ent", "<e2>", "levels", "normalized", "."], "h": {"id": "C0042680", "name": "C0042680#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705340", "name": "C1705340#ent", "pos": [25, 26]}}
{"token": ["Efficient", "export", "of", "cadherins", "from", "the", "endoplasmic", "reticulum", "C1414461#ent", "<e1>", ")", "is", "known", "to", "require", "complex", "formation", "with", "C1332803#ent", "<e2>", "."], "h": {"id": "C1414461", "name": "C1414461#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [18, 19]}}
{"token": ["Almost", "identical", "results", "were", "obtained", "with", "C0010620#ent", "<e1>", ",", "a", "serotoninergic", ",", "C0242704#ent", "<e2>", "and", "cholinergic", "blocker", "agent", "2", "mg", "q.i.d", ".", ";"], "h": {"id": "C0010620", "name": "C0010620#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0242704", "name": "C0242704#ent", "pos": [12, 13]}}
{"token": ["It", "does", "not", "appear", "to", "be", "androgen-induced", ",", "yet", "is", "absent", "in", "C3889249#ent", "<e1>", "of", "most", "patients", "with", "complete", "C0268301#ent", "<e2>", "CAI", ")", "."], "h": {"id": "C3889249", "name": "C3889249#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0268301", "name": "C0268301#ent", "pos": [19, 20]}}
{"token": ["LPS-unresponsive", "C3H/HeJ", "or", "C57BL/10Sc", "mice", "not", "respond", "to", "C0175697#ent", "<e1>", "with", "an", "increase", "in", "C1420017#ent", "<e2>", "synthesis", "."], "h": {"id": "C0175697", "name": "C0175697#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1420017", "name": "C1420017#ent", "pos": [14, 15]}}
{"token": ["The", "action", "of", "C1419240#ent", "<e1>", "blocked", "forks", "is", "not", "necessarily", "accompanied", "by", "a", "C1173619#ent", "<e2>", "may", "prevent", "rather", "than", "repair", "fork", "breakage", "."], "h": {"id": "C1419240", "name": "C1419240#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1173619", "name": "C1173619#ent", "pos": [13, 14]}}
{"token": ["A", "30-year-old", "woman", "with", "C0268164#ent", "<e1>", "PHI", ")", "developed", "C0085642#ent", "<e2>", "overlying", "ulcerations", "on", "her", "legs", "16", "months", "after", "receiving", "a", "liver-kidney", "transplant"], "h": {"id": "C0268164", "name": "C0268164#ent", "pos": [4, 5]}, "relation": "has_manifestation", "t": {"id": "C0085642", "name": "C0085642#ent", "pos": [9, 10]}}
{"token": ["Pulse-chase", "metabolic", "labelling", "of", "transfected", "COS", "cells", "that", "three", "chains", "(", "CD3", "gamma", "CD3", "epsilon", "and", "C1419007#ent", "<e1>", ")", "were", "stable", "while", "three", "(", "TCR", "alpha", "C0524891#ent", "<e2>", "CD3", "delta", "were", "rapidly", "degraded", "."], "h": {"id": "C1419007", "name": "C1419007#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0524891", "name": "C0524891#ent", "pos": [26, 27]}}
{"token": ["To", "determine", "whether", "IP-10", "and", "C1707170#ent", "<e1>", "are", "released", "during", "C0004623#ent", "<e2>", "humans", ",", "we", "measured", "plasma", "levels", "of", "IP-10", "and", "C1707170#ent", "<e1>", "in", "patients", "with", "melioidosis", ",", "a", "severe", "gram-negative", "infection", "by", "Burkholderia", "pseudomallei"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1707170", "name": "C1707170#ent", "pos": [5, 6]}}
{"token": ["Perindopril", ",", "losartan", "and", "C0053799#ent", "<e1>", "decreased", "BP", "to", "a", "similar", "extent", ",", "and", "either", "C0070426#ent", "<e2>", "or", "losartan", ",", "but", "not", "C0053799#ent", "<e1>", ",", "significantly", "decreased", "serum", "ADMA", "and", "plasma", "vWF", "."], "h": {"id": "C0053799", "name": "C0053799#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0070426", "name": "C0070426#ent", "pos": [15, 16]}}
{"token": ["C0011849#ent", "<e1>", "is", "specifically", "associated", "with", "categories", "of", "primary", "glaucoma", "C0017605#ent", "<e2>", "narrow-angle", "patients", "ocular", "hypertension", "open-angle", "glaucoma"], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017605", "name": "C0017605#ent", "pos": [10, 11]}}
{"token": ["The", "aim", "of", "the", "present", "study", "was", "to", "elucidate", "the", "role", "of", "the", "alpha-isoform", "of", "C0244989#ent", "<e1>", "in", "insulin", "resistance", "human", "skeletal", "muscle", "cells", "C0362046#ent", "<e2>", "subjects", "maintained", "in", "culture", "."], "h": {"id": "C0244989", "name": "C0244989#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0362046", "name": "C0362046#ent", "pos": [24, 25]}}
{"token": ["To", "investigate", "the", "C2926735#ent", "<e1>", "of", "bronchodilator", "action", "of", "a", "salmeterol/fluticasone", "combination", "(", "C0723176#ent", "<e2>", ")", "inhaler", "when", "administered", "in", "the", "evening", "to", "children", "with", "asthma", "."], "h": {"id": "C2926735", "name": "C2926735#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0723176", "name": "C0723176#ent", "pos": [13, 14]}}
{"token": ["C0694884#ent", "<e1>", "is", "a", "C1848862#ent", "<e2>", "of", "parathyroid", "adenomas", "gastrinomas", ",", "prolactinomas", ",", "and", "other", "endocrine", "tumors"], "h": {"id": "C0694884", "name": "C0694884#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1848862", "name": "C1848862#ent", "pos": [4, 5]}}
{"token": ["Several", "lines", "of", "evidence", ",", "including", "familial", "aggregation", "suggest", "that", "C0002085#ent", "<e1>", "variation", "contributes", "to", "risk", "of", "C1442864#ent", "<e2>"], "h": {"id": "C0002085", "name": "C0002085#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1442864", "name": "C1442864#ent", "pos": [17, 18]}}
{"token": ["This", "FMR2-related", "C1517488#ent", "<e1>", "nuclear", "proteins", "involvement", "in", "mental", "retardation", "C1826605#ent", "<e2>", ")", ",", "cancer", "(", "AF4", ")", ",", "and", "lymphocyte", "differentiation", "LAF4", ")", "or", "with", "unknown", "function", "(", "EST", "W26686", "and/or", "AA025630", ")", "."], "h": {"id": "C1517488", "name": "C1517488#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1826605", "name": "C1826605#ent", "pos": [10, 11]}}
{"token": ["The", "effects", "of", "FFA", "were", "blocked", "by", "the", "C1415803#ent", "<e1>", "not", "by", "the", "5-HT2", "antagonist", "C0025912#ent", "<e2>", "."], "h": {"id": "C1415803", "name": "C1415803#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0025912", "name": "C0025912#ent", "pos": [15, 16]}}
{"token": ["In", "addition", ",", "C3538961#ent", "<e1>", "CRBPs", "and", "CRABPs", ")", "and", "RA-metabolizing", "C3541394#ent", "<e2>", "may", "explain", "the", "pleiotropic", "effects", "of", "retinoids", "."], "h": {"id": "C3538961", "name": "C3538961#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [11, 12]}}
{"token": ["Taken", "together", ",", "these", "data", "demonstrate", "that", "the", "C0257535#ent", "<e1>", "down-regulates", "ERK", "via", "activation", "of", "C1414187#ent", "<e2>", "in", "human", "monocytes", "exposed", "to", "asbestos", "to", "enhance", "TNF-alpha", "gene", "expression", "."], "h": {"id": "C0257535", "name": "C0257535#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1414187", "name": "C1414187#ent", "pos": [15, 16]}}
{"token": ["Crigler-Najjar", "(", "CN", ")", "syndrome", "is", "a", "congenital", "familial", "C0242183#ent", "<e1>", "associated", "with", "level", "of", "unconjugated", "bilirubin", "due", "to", "deficient", "C1259497#ent", "<e2>", "UDPG-T", ")", "activity", "in", "the", "liver", "."], "h": {"id": "C0242183", "name": "C0242183#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1259497", "name": "C1259497#ent", "pos": [20, 21]}}
{"token": ["Patients", "develop", "severe", "intractable", "symptoms", ",", "incapacitating", "dysphagia", ",", "and", ",", "with", "C2316810#ent", "<e1>", "stricture", "formation", "or", "C0004763#ent", "<e2>"], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0004763", "name": "C0004763#ent", "pos": [17, 18]}}
{"token": ["Serum", "and", "leukocyte", "hexosaminidase", "profiles", "(", "total", "activity", "percent", "heat-labile", "activity", "levels", ")", "in", "obligate", "Sandhoff", "disease", "C1822716#ent", "<e1>", ")", "heterozygotes", "differ", "from", "those", "of", "obligate", "Tay-Sachs", "disease", "C0007427#ent", "<e2>", ")", "heterozygotes", "and", "noncarrier", "individuals", "."], "h": {"id": "C1822716", "name": "C1822716#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0007427", "name": "C0007427#ent", "pos": [28, 29]}}
{"token": ["A", "new", "potent", "proton", "pump", "inhibitor", "E3810", ",", "had", "an", "antibacterial", "effect", "H.", "pylori", "as", "has", "been", "reported", "for", "C0028978#ent", "<e1>", "and", "lansoprazole", ",", "two", "other", "C3540020#ent", "<e2>"], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3540020", "name": "C3540020#ent", "pos": [26, 27]}}
{"token": ["A", "member", "of", "the", "A", "disintegrin", "and", "C1334706#ent", "<e1>", "thrombospondin", "type-1", "motifs", "(", "C1412209#ent", "<e2>", ")", "protease", "family", "efficiently", "cleave", "aggrecan", "at", "several", "sites", "detected", "in", "joints", "of", "osteoarthritic", "patients", "."], "h": {"id": "C1334706", "name": "C1334706#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1412209", "name": "C1412209#ent", "pos": [13, 14]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "examine", "the", "relationship", "between", "IMT", "and", "brain", "activity", "a", "verbal", "working", "memory", "C1858991#ent", "<e1>", ")", "task", "in", "patients", "with", "cardiovascular", "disease", "C0007820#ent", "<e2>", ")", "."], "h": {"id": "C1858991", "name": "C1858991#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0007820", "name": "C0007820#ent", "pos": [28, 29]}}
{"token": ["Rats", "were", "C0342895#ent", "<e1>", "a", "grape", "seed", "extract", "GSE", ")", "containing", "(+)-catechin", ",", "C1881340#ent", "<e2>", "and", "dimers", ",", "trimers", ",", "tetramers", "and", "polymeric", "procyanidins"], "h": {"id": "C0342895", "name": "C0342895#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1881340", "name": "C1881340#ent", "pos": [13, 14]}}
{"token": ["Three", "different", "C0174045#ent", "<e1>", "been", "shown", "to", "mediate", "polarization", "in", "the", "C3538717#ent", "<e2>", "and", "the", "eye", "of", "Drosophila", "."], "h": {"id": "C0174045", "name": "C0174045#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3538717", "name": "C3538717#ent", "pos": [11, 12]}}
{"token": ["Knockdown", "of", "p53", "protein", "breast", "cancer", "cells", "siRNA", "followed", "by", "C1121519#ent", "<e1>", "treatment", "resulted", "in", "decline", "of", "C0812198#ent", "<e2>", "and", "PUMA", "proteins", "expression", "."], "h": {"id": "C1121519", "name": "C1121519#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [17, 18]}}
{"token": ["The", "upregulation", "of", "REG3A", "and", "C1419333#ent", "<e1>", "expression", "is", "significantly", "correlated", "to", "the", "C1332803#ent", "<e2>", "42", "HCC", "and", "28", "hepatoblastomas", "characterized", "for", "their", "C1332803#ent", "<e2>"], "h": {"id": "C1419333", "name": "C1419333#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [13, 14]}}
{"token": ["Dendritic", "cells", "DC", ")", "are", "the", "most", "potent", "C1456795#ent", "<e1>", "capable", "of", "priming", "both", "C0017349#ent", "<e2>", "II-restricted", ",", "Ag-specific", "T", "cell", "responses", "."], "h": {"id": "C1456795", "name": "C1456795#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017349", "name": "C0017349#ent", "pos": [14, 15]}}
{"token": ["In", "this", "study", "we", "investigated", "the", "relationship", "between", "C1332735#ent", "<e1>", "activity", "and", "regulation", "of", "the", "C1979930#ent", "<e2>", "MAP", ")", "kinase", "pathway"], "h": {"id": "C1332735", "name": "C1332735#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1979930", "name": "C1979930#ent", "pos": [15, 16]}}
{"token": ["To", "describe", "an", "association", "between", "continuous", "simple", "partial", "C0036572#ent", "<e1>", "and", "independent", "right", "and", "C0751495#ent", "<e2>", "children", "with", "benign", "childhood", "epilepsy", "with", "centrotemporal", "spikes", "(", "BCECTS", ")", "."], "h": {"id": "C0036572", "name": "C0036572#ent", "pos": [8, 9]}, "relation": "nichd_parent_of", "t": {"id": "C0751495", "name": "C0751495#ent", "pos": [14, 15]}}
{"token": ["Volume", "depletion", "to", "gastrointestinal", "fluid", "loss", "C0178879#ent", "<e1>", "account", "of", "enlarged", "prostate", "were", "the", "leading", "causes", "of", "C1705280#ent", "<e2>", "in", "20", "(", "35.7", "%", ")", "and", "8", "(", "14.3", "%", ")", "cases", "respectively", "."], "h": {"id": "C0178879", "name": "C0178879#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1705280", "name": "C1705280#ent", "pos": [17, 18]}}
{"token": ["12", "patients", "admitted", "for", "C0027765#ent", "<e1>", "suffering", "from", "C0037317#ent", "<e2>", "were", "given", "Flunitrazepam", "and", "placebo", "(", "double", "blind", "test", "in", "a", "single", "evening", "dose", "of", "1", "and", "2", "mg", "."], "h": {"id": "C0027765", "name": "C0027765#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0037317", "name": "C0037317#ent", "pos": [8, 9]}}
{"token": ["Here", ",", "we", "established", "an", "efficient", "proteomics", "method", "employing", "an", "immobilized", "C0048852#ent", "<e1>", "an", "affinity", "probe", "identified", "more", "than", "30", "human", "C0033640#ent", "<e2>", "by", "this", "class", "of", "compounds", "."], "h": {"id": "C0048852", "name": "C0048852#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [21, 22]}}
{"token": ["C0342482#ent", "<e1>", "AHC", ")", "is", "a", "disorder", "associated", "with", "C0001403#ent", "<e2>", "hypogonadotropic", "hypogonadism", "HH", ")", "."], "h": {"id": "C0342482", "name": "C0342482#ent", "pos": [0, 1]}, "relation": "has_manifestation", "t": {"id": "C0001403", "name": "C0001403#ent", "pos": [9, 10]}}
{"token": ["The", "mutant", "plasmid", "severely", "inhibited", "export", "of", "C0065661#ent", "<e1>", "less", "severely", "of", "C0039683#ent", "<e2>", ",", "when", "introduced", "into", "sec+", "cells", "."], "h": {"id": "C0065661", "name": "C0065661#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0039683", "name": "C0039683#ent", "pos": [12, 13]}}
{"token": ["C0059409#ent", "<e1>", "from", "normal", "eosinophils", "from", "eosinophils", "from", "one", "patient", "with", "C0745091#ent", "<e2>", "seemed", "to", "be", "identical", "."], "h": {"id": "C0059409", "name": "C0059409#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0745091", "name": "C0745091#ent", "pos": [11, 12]}}
{"token": ["Compared", "to", "the", "surrounding", "tissue", ",", "these", "foci", "also", "exhibited", "a", "more", "pronounced", "staining", "for", "C1415328#ent", "<e1>", "mu", "isoforms", "a", "stronger", "inducibility", "of", "the", "C0010762#ent", "<e2>", "expression", "due", "to", "beta-naphthoflavone", "."], "h": {"id": "C1415328", "name": "C1415328#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0010762", "name": "C0010762#ent", "pos": [24, 25]}}
{"token": ["The", "augmentation", "of", "antibody", "production", "to", "Coxsackie", "A13", "virus", "well", "as", "protective", "effect", "C0021400#ent", "<e1>", "been", "found", "out", "in", "mice", "after", "C1415169#ent", "<e2>", "injections", "."], "h": {"id": "C0021400", "name": "C0021400#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1415169", "name": "C1415169#ent", "pos": [21, 22]}}
{"token": ["C2242703#ent", "<e1>", "also", "known", "as", "microvascular", "angina", "is", "characterized", "by", "C1850830#ent", "<e2>", "despite", "a", "normal", "coronary", "angiogram"], "h": {"id": "C2242703", "name": "C2242703#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1850830", "name": "C1850830#ent", "pos": [10, 11]}}
{"token": ["A", "patient", "with", "C0149520#ent", "<e1>", "to", "Candida", "albicans", "Candida", "parapsilosis", "treated", "with", "percutaneous", "cholecystostomy", "daily", "C0016277#ent", "<e2>"], "h": {"id": "C0149520", "name": "C0149520#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0016277", "name": "C0016277#ent", "pos": [15, 16]}}
{"token": ["The", "C0000294#ent", "<e1>", "rats", "on", "injection", "of", "carbachol", "also", "preferred", "C0036023#ent", "<e2>", "apart", "from", "NaCl", "."], "h": {"id": "C0000294", "name": "C0000294#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0036023", "name": "C0036023#ent", "pos": [10, 11]}}
{"token": ["C1420786#ent", "<e1>", "mRNA", "was", "C0907533#ent", "<e2>", "expressed", "as", "a", "single", "(", "greater", "than", "600-nucleotide", ")", "abundant", "transcript", "in", "the", "immature", "rat", "ovary"], "h": {"id": "C1420786", "name": "C1420786#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0907533", "name": "C0907533#ent", "pos": [4, 5]}}
{"token": ["Chromatin", "immunoprecipitation", "that", "C1333573#ent", "<e1>", "complexes", "with", "C1333897#ent", "<e2>", "and", "p300", "on", "the", "Glut-1", "promoter", ",", "a", "HIF-1", "target", "gene", "."], "h": {"id": "C1333573", "name": "C1333573#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1333897", "name": "C1333897#ent", "pos": [7, 8]}}
{"token": ["Similarly", ",", "C0057223#ent", "<e1>", "inactivation", "also", "was", "prevented", "by", "C0034414#ent", "<e2>", ",", "a", "specific", "competitive", "inhibitor", "of", "this", "isoform", "."], "h": {"id": "C0057223", "name": "C0057223#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034414", "name": "C0034414#ent", "pos": [9, 10]}}
{"token": ["These", "results", "thus", "define", "three", "new", "groups", ",", "FA-F", ",", "FA-G", ",", "and", "C2828026#ent", "<e1>", ",", "providing", "evidence", "for", "a", "minimum", "of", "eight", "distinct", "C3469521#ent", "<e2>", "genes", "."], "h": {"id": "C2828026", "name": "C2828026#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3469521", "name": "C3469521#ent", "pos": [24, 25]}}
{"token": ["The", "results", "of", "this", "study", "indicate", "an", "imbalance", "between", "the", "utilization", "and", "resynthesis", "of", "C1705556#ent", "<e1>", "in", "resting", "muscle", "patients", "with", "stable", "C0024117#ent", "<e2>", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0024117", "name": "C0024117#ent", "pos": [22, 23]}}
{"token": ["C1416571#ent", "<e1>", "also", "increased", "the", "release", "of", "C1418616#ent", "<e2>", "in", "cells", "subsequently", "stimulated", "with", "fMLP", "."], "h": {"id": "C1416571", "name": "C1416571#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1418616", "name": "C1418616#ent", "pos": [7, 8]}}
{"token": ["We", "determined", "how", "C0063164#ent", "<e1>", "inhibition", "affected", "the", "mitogenic", "effects", "C1334089#ent", "<e2>", "and", "metabolic", "actions", "of", "insulin", "in", "3T3-L1", "cells", "examined", "the", "respective", "roles", "of", "receptor", "glycosylation", "Ras", "prenylation"], "h": {"id": "C0063164", "name": "C0063164#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1334089", "name": "C1334089#ent", "pos": [10, 11]}}
{"token": ["Like", "its", "homologue", "in", "vaccinia", "virus", "the", "mature", "HaEPV", "30", "C0072366#ent", "<e1>", "derived", "by", "post-translational", "cleavage", "a", "precursor", "at", "a", "conserved", "C0162311#ent", "<e2>", "motif", "."], "h": {"id": "C0072366", "name": "C0072366#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162311", "name": "C0162311#ent", "pos": [21, 22]}}
{"token": ["It", "was", "concluded", "that", "altered", "pharmacokinetics", "do", "not", "account", "for", "the", "increased", "drug", "requirement", "of", "C0028978#ent", "<e1>", "in", "patients", "with", "the", "C0043515#ent", "<e2>"], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [15, 16]}, "relation": "may_treat", "t": {"id": "C0043515", "name": "C0043515#ent", "pos": [21, 22]}}
{"token": ["N-methyl-d-aspartate", "(NMDA)-induced", "C0742078#ent", "<e1>", "not", "elicit", "a", "systemic", "C1321914#ent", "<e2>", "."], "h": {"id": "C0742078", "name": "C0742078#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1321914", "name": "C1321914#ent", "pos": [8, 9]}}
{"token": ["Western", "blot", "profile", "rarely", "of", "strong", "poly", "band", "more", "frequently", "of", "weak", "oligo", "band", "pattern", "with", "absent", "or", "weak", "C1423526#ent", "<e1>", "compared", "to", "C3539699#ent", "<e2>", "."], "h": {"id": "C1423526", "name": "C1423526#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C3539699", "name": "C3539699#ent", "pos": [23, 24]}}
{"token": ["The", "CAS", "can", "be", "caused", "by", "atropine", "sulphate", "C0036442#ent", "<e1>", "(", "scopolamine", ")", ",", "promethazine", ",", "C0005064#ent", "<e2>", ",", "opioids", ",", "halothane", ",", "influrane", ",", "ketamine", "."], "h": {"id": "C0036442", "name": "C0036442#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005064", "name": "C0005064#ent", "pos": [16, 17]}}
{"token": ["The", "C0035319#ent", "<e1>", "manifested", "by", "C0042164#ent", "<e2>", "vitritis", ",", "retinal", "vasculitis", "and", "acute", "necrotizing", "retinitis", "see", "Part", "1", ")", "."], "h": {"id": "C0035319", "name": "C0035319#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0042164", "name": "C0042164#ent", "pos": [5, 6]}}
{"token": ["C0031428#ent", "<e1>", "was", "coupled", "to", "C0019139#ent", "<e2>", "producing", "phenol-peptide", "conjugates", "."], "h": {"id": "C0031428", "name": "C0031428#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0019139", "name": "C0019139#ent", "pos": [5, 6]}}
{"token": ["The", "tissue", "inhibitor", "C0127082#ent", "<e1>", "TIMP-1", ")", "has", "been", "recognized", "as", "a", "C0536221#ent", "<e2>"], "h": {"id": "C0127082", "name": "C0127082#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0536221", "name": "C0536221#ent", "pos": [12, 13]}}
{"token": ["It", "seems", "probable", "that", "cell-mediated", "mechanisms", "are", "involved", "in", "the", "pathogenesis", "of", "certain", "forms", "of", "C0027707#ent", "<e1>", "and", "glomerular", "disease", "in", "particular", ",", "C2584556#ent", "<e2>", "pyelonephritis", ",", "anti-GBM", "nephritis", "and", "certain", "forms", "of", "acute", "glomerulonephritis"], "h": {"id": "C0027707", "name": "C0027707#ent", "pos": [15, 16]}, "relation": "nichd_parent_of", "t": {"id": "C2584556", "name": "C2584556#ent", "pos": [23, 24]}}
{"token": ["The", "leucine", "7", "proline", "7", "Leu7Pro", ")", "polymorphism", "in", "the", "signal", "peptide", "C1705518#ent", "<e1>", "is", "associated", "with", "high", "blood", "concentrations", "and", "accelerated", "rate", "of", "C0003850#ent", "<e2>", "as", "well", "as", "diabetic", "retinopathy"], "h": {"id": "C1705518", "name": "C1705518#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [24, 25]}}
{"token": ["Renal", "functional", "correlated", "with", "other", "manifestations", "of", "severe", "sepsis", "--", "GFR", "and", "sodium", "retention", "significantly", "with", "increased", "cardiac", "index", "decreased", "systemic", "vascular", "resistance", "C3203102#ent", "<e1>", "leukopenia", ",", "hypoproteinemia", ",", "and", "C0020615#ent", "<e2>", "."], "h": {"id": "C3203102", "name": "C3203102#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [30, 31]}}
{"token": ["A", "case", "of", "C1510428#ent", "<e1>", "a", "49-year-old", "female", "was", "initially", "diagnosed", "as", "a", "C0018681#ent", "<e2>", "."], "h": {"id": "C1510428", "name": "C1510428#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0018681", "name": "C0018681#ent", "pos": [13, 14]}}
{"token": ["Human", "C0656016#ent", "<e1>", "is", "a", "mast", "cell", "C1416671#ent", "<e2>", "is", "thought", "to", "play", "a", "key", "role", "in", "the", "pathogenesis", "of", "diverse", "allergic", "and", "inflammatory", "disorders", "asthma", "and", "psoriasis", "."], "h": {"id": "C0656016", "name": "C0656016#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1416671", "name": "C1416671#ent", "pos": [7, 8]}}
{"token": ["A", "middle", "aged", "female", "suffering", "from", "C0398650#ent", "<e1>", "ITP", ")", ",", "on", "treatment", "with", "C0038317#ent", "<e2>", ",", "developed", "bronchopneumonia", "and", "pyopneumothorax", "due", "to", "opportunistic", "infection", "Nocardia", "asteroides"], "h": {"id": "C0398650", "name": "C0398650#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0038317", "name": "C0038317#ent", "pos": [14, 15]}}
{"token": ["The", "effect", "of", "C0023556#ent", "<e1>", "on", "natural", "killer", "NK", ")", "and", "C1705132#ent", "<e2>", "(", "K", ")", "cell", "activities", "on", "interferon", "production", "determined", "in", "both", "normal", "subjects", "cancer", "patients", "."], "h": {"id": "C0023556", "name": "C0023556#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1705132", "name": "C1705132#ent", "pos": [11, 12]}}
{"token": ["Phosphatidylinositol-3-kinase", "(PI3K)-dependent", "C0812228#ent", "<e1>", "activation", "induced", "by", "C2698414#ent", "<e2>", "was", "also", "inhibited", "by", "simvastatin", "."], "h": {"id": "C0812228", "name": "C0812228#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C2698414", "name": "C2698414#ent", "pos": [7, 8]}}
{"token": ["Indeed", ",", "immortalized", "progenitor", "cell", "lines", "respond", "to", "both", "C1414438#ent", "<e1>", "and", "SCF", ",", "continue", "to", "express", "C1422793#ent", "<e2>", "switched", "from", "C1414438#ent", "<e1>", "to", "SCF", "."], "h": {"id": "C1414438", "name": "C1414438#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1422793", "name": "C1422793#ent", "pos": [17, 18]}}
{"token": ["C1420015#ent", "<e1>", "MPS", "IIIA", ";", "C0026706#ent", "<e2>", "is", "a", "lysosomal", "storage", "disorder", "by", "severe", "CNS", "degeneration", ",", "resulting", "in", "behavioral", "abnormalities", "loss", "of", "learned", "abilities", "."], "h": {"id": "C1420015", "name": "C1420015#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026706", "name": "C0026706#ent", "pos": [5, 6]}}
{"token": ["In", "this", "study", ",", "we", "examined", "a", "possible", "role", "of", "C0162508#ent", "<e1>", "in", "the", "transcription", "of", "C0035094#ent", "<e2>"], "h": {"id": "C0162508", "name": "C0162508#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0035094", "name": "C0035094#ent", "pos": [16, 17]}}
{"token": ["Beyond", "demonstrating", "the", "comorbidity", "between", "C0149931#ent", "<e1>", "and", "C0751152#ent", "<e2>", "the", "data", "suggest", "that", "C0149931#ent", "<e1>", "may", "represent", "a", "risk", "factor", "fibromyalgia", "."], "h": {"id": "C0751152", "name": "C0751152#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0149931", "name": "C0149931#ent", "pos": [5, 6]}}
{"token": ["This", "C0014442#ent", "<e1>", "was", "originally", "recognized", "by", "its", "action", "of", "producing", "C0039534#ent", "<e2>", "a", "plasma", "protein"], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0039534", "name": "C0039534#ent", "pos": [11, 12]}}
{"token": ["The", "inhibition", "was", "unaffected", "by", "rapamycin", "at", "concentrations", "which", "blocked", "the", "activation", "of", "C1138418#ent", "<e1>", "and", "reversed", "by", "incubation", "with", "C0031686#ent", "<e2>"], "h": {"id": "C1138418", "name": "C1138418#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0031686", "name": "C0031686#ent", "pos": [20, 21]}}
{"token": ["C1422243#ent", "<e1>", "binding", "to", "Cbl", "is", "increased", "after", "C0812325#ent", "<e2>", "stimulation", "and", "is", "critical", "for", "targeting", "receptor", "tyrosine", "kinases", "clathrin-mediated", "endocytosis", "."], "h": {"id": "C1422243", "name": "C1422243#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0812325", "name": "C0812325#ent", "pos": [8, 9]}}
{"token": ["Specific", "diseases", "associated", "with", "agricultural", "environment", "were", "identified", "as", "C1334103#ent", "<e1>", "asthma", ",", "pneumonitis/alveolitis", ",", "the", "organic", "dust", "toxic", "syndrome", "C0149514#ent", "<e2>", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0149514", "name": "C0149514#ent", "pos": [20, 21]}}
{"token": ["The", "C0039082#ent", "<e1>", "is", "due", "at", "least", "in", "part", "to", "C0010073#ent", "<e2>"], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010073", "name": "C0010073#ent", "pos": [10, 11]}}
{"token": ["Utilizing", "cholesteryl", "esters", "on", "either", "the", "cholesterol", "or", "the", "fatty", "acid", "moiety", "we", "demonstrated", "that", "C1142985#ent", "<e1>", "did", "not", "affect", "C0008385#ent", "<e2>", "hydrolysis", "and", "the", "absorption", "of", "fatty", "acid", "generated", "in", "both", "hamsters", "and", "rats", "."], "h": {"id": "C1142985", "name": "C1142985#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0008385", "name": "C0008385#ent", "pos": [20, 21]}}
{"token": ["C0020488#ent", "<e1>", "of", "rat", "liver", "lysosomes", "by", "Triton", "C3538902#ent", "<e2>", "1339", "was", "accompanied", "by", "the", "labilization", "of", "lysosomes", "and", "an", "increased", "uptake", "of", "[14C]-bovine", "serum", "albumin", "[14C]-BSA", ")", "by", "the", "rat", "liver", "."], "h": {"id": "C0020488", "name": "C0020488#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3538902", "name": "C3538902#ent", "pos": [8, 9]}}
{"token": ["We", "did", "not", "find", "evidence", "that", "C0086132#ent", "<e1>", "reliably", "associated", "with", "modulation", "of", "either", "C0919336#ent", "<e2>", "or", "TIMP", "expression", "."], "h": {"id": "C0086132", "name": "C0086132#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0919336", "name": "C0919336#ent", "pos": [14, 15]}}
{"token": ["Recently", ",", "mutations", "in", "barttin", ",", "a", "protein", "not", "related", "to", "any", "known", "ion", "transporter", "channel", ",", "were", "described", "in", "C1865270#ent", "<e1>", ",", "a", "variant", "of", "Bartter", "syndrome", "associated", "with", "C0018784#ent", "<e2>"], "h": {"id": "C1865270", "name": "C1865270#ent", "pos": [20, 21]}, "relation": "has_manifestation", "t": {"id": "C0018784", "name": "C0018784#ent", "pos": [30, 31]}}
{"token": ["The", "changes", "in", "LDH", "C0022173#ent", "<e1>", "were", "helpful", "to", "the", "differential", "diagnosis", "C0155388#ent", "<e2>", "and", "the", "increase", "of", "MDHm", "reflected", "sensitively", "the", "degree", "of", "injury", "to", "the", "corneal", "epithelium"], "h": {"id": "C0022173", "name": "C0022173#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0155388", "name": "C0155388#ent", "pos": [12, 13]}}
{"token": ["Next", ",", "we", "investigated", "the", "possibility", "of", "gliclazide", "inducing", "t-PA-related", "fibrinolysis", "in", "a", "subset", "of", "Type", "II", "diabetics", "without", "detectable", "concentrations", "of", "C0032143#ent", "<e1>", "during", "treatment", "with", "C0040374#ent", "<e2>", "."], "h": {"id": "C0032143", "name": "C0032143#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [27, 28]}}
{"token": ["These", "effects", "suggest", "that", "HCO3-", "and", "Cl-", "are", "involved", "in", "the", "C2984892#ent", "<e1>", "of", "the", "C1335499#ent", "<e2>", ",", "whereas", "Na+", "is", "not", "directly", "responsible", "of", "the", "C1335499#ent", "<e2>", "."], "h": {"id": "C2984892", "name": "C2984892#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1335499", "name": "C1335499#ent", "pos": [15, 16]}}
{"token": ["The", "results", "showed", "that", "the", "degradable", "speed", "of", "C0136335#ent", "<e1>", "was", "faster", "in", "C0036088#ent", "<e2>", "in", "PBS", "solution", "."], "h": {"id": "C0136335", "name": "C0136335#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0036088", "name": "C0036088#ent", "pos": [13, 14]}}
{"token": ["Of", "the", "tumors", "immunostaining", "for", "luteinizing", "hormone", "LH", ")", ",", "follicle-stimulating", "hormone", "C0016424#ent", "<e1>", ")", ",", "or", "both", ",", "C0038880#ent", "<e2>", "mRNA", "was", "present", "in", "small", "amounts", "5/11", "."], "h": {"id": "C0016424", "name": "C0016424#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0038880", "name": "C0038880#ent", "pos": [19, 20]}}
{"token": ["In", "all", "eukaryotes", "studied", ",", "C1563761#ent", "<e1>", "two", "highly", "hydrophobic", "proteins", "in", "respiration", ",", "C1419909#ent", "<e2>", "cytochrome", "oxidase"], "h": {"id": "C1563761", "name": "C1563761#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1419909", "name": "C1419909#ent", "pos": [14, 15]}}
{"token": ["Progressive", "dementia", "C0029089#ent", "<e1>", "and", "prominent", "hypothalamic", "dysfunction", "in", "one", "patient", "with", "documented", "intestinal", "C0023788#ent", "<e2>", "ongoing", "antibiotic", "therapy", "intestinal", "remission"], "h": {"id": "C0029089", "name": "C0029089#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023788", "name": "C0023788#ent", "pos": [14, 15]}}
{"token": ["Contrary", "to", "expectations", ",", "pretreatment", "with", "C1333674#ent", "<e1>", "did", "not", "suppress", "but", "enhanced", "secretion", "of", "cortisol", "upon", "C2825234#ent", "<e2>", "of", "the", "route", "of", "C1333674#ent", "<e1>", "pretreatment", "(", "p<0.05", ")", "."], "h": {"id": "C1333674", "name": "C1333674#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2825234", "name": "C2825234#ent", "pos": [17, 18]}}
{"token": ["Initial", "cleavage", "is", "catalysed", "by", "C1709966#ent", "<e1>", ",", "a", "nuclease", "of", "the", "C0073240#ent", "<e2>", "which", "acts", "on", "primary", "miRNA", "transcripts", "(", "pri-miRNAs", ")", "in", "the", "nucleus", "."], "h": {"id": "C1709966", "name": "C1709966#ent", "pos": [5, 6]}, "relation": "gene_encodes_gene_product", "t": {"id": "C0073240", "name": "C0073240#ent", "pos": [12, 13]}}
{"token": ["Human", "beta", "C1412851#ent", "<e1>", "identified", "by", "interaction", "with", "Vpu", "connects", "C1332714#ent", "<e2>", "to", "this", "proteolytic", "machinery", "and", "CD4-Vpu-beta", "TrCP", "ternary", "complexes", "been", "detected", "by", "coimmunoprecipitation", "."], "h": {"id": "C1412851", "name": "C1412851#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1332714", "name": "C1332714#ent", "pos": [10, 11]}}
{"token": ["The", "father", "has", "C1334103#ent", "<e1>", "his", "nephew", "suffers", "C4025277#ent", "<e2>", "collapse", "."], "h": {"id": "C1334103", "name": "C1334103#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C4025277", "name": "C4025277#ent", "pos": [8, 9]}}
{"token": ["nNOS", "has", "been", "known", "to", "interact", "with", "C1333226#ent", "<e1>", "and", "a", "related", "protein", ",", "C1414064#ent", "<e2>", ",", "in", "brain", "and", "with", "alpha1-syntrophin", "in", "skeletal", "muscle", "mammals", "."], "h": {"id": "C1333226", "name": "C1333226#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1414064", "name": "C1414064#ent", "pos": [14, 15]}}
{"token": ["Circulating", "sex", "steroids", "contribute", "little", "to", "the", "mating-induced", "stimulation", "of", "C1706383#ent", "<e1>", ",", "even", "in", "brain", "regions", "to", "contain", "high", "levels", "of", "C3536949#ent", "<e2>", "and", "estrogen", "receptor"], "h": {"id": "C1706383", "name": "C1706383#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3536949", "name": "C3536949#ent", "pos": [22, 23]}}
{"token": ["These", "results", "provide", "additional", "evidence", "supporting", "the", "combined", "systemic", "expression", "of", "antiangiogenic", "factors", "such", "as", "C0290149#ent", "<e1>", "3", ",", "endostatin", ",", "and", "C1137277#ent", "<e2>", ",", "as", "an", "alternative", "procedure", "antiangiogenic", "cancer", "therapy"], "h": {"id": "C0290149", "name": "C0290149#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1137277", "name": "C1137277#ent", "pos": [22, 23]}}
{"token": ["Here", "we", "report", "a", "patient", "with", "C0206744#ent", "<e1>", "presenting", "with", "an", "C0029118#ent", "<e2>", "Rhodococcus", "equi", "infection"], "h": {"id": "C0206744", "name": "C0206744#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0029118", "name": "C0029118#ent", "pos": [11, 12]}}
{"token": ["The", "vestibular", "examination", "proved", "that", "about", "half", "the", "patients", "(", "80/163", ")", "suffered", "from", "C0494559#ent", "<e1>", "mainly", "of", "peripheral", "origin", "BPV", ",", "Meni\u00e8re's", "disease", "C0751908#ent", "<e2>", "."], "h": {"id": "C0494559", "name": "C0494559#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0751908", "name": "C0751908#ent", "pos": [24, 25]}}
{"token": ["Antagonism", "of", "this", "current", "may", "contribute", "to", "the", "C3537142#ent", "<e1>", "actions", "of", "adenosine", "and", "C2744579#ent", "<e2>", "but", "their", "mechanisms", "of", "action", "are", "yet", "to", "be", "determined", "."], "h": {"id": "C3537142", "name": "C3537142#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2744579", "name": "C2744579#ent", "pos": [14, 15]}}
{"token": ["Our", "study", "investigates", "the", "role", "of", "the", "IL-1B-31", ",", "C3273854#ent", "<e1>", "and", "TNF-A-308", "gene", "polymorphisms", "as", "risk", "factors", "the", "development", "of", "C1367452#ent", "<e2>", "in", "a", "Mexican", "population"], "h": {"id": "C3273854", "name": "C3273854#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1367452", "name": "C1367452#ent", "pos": [21, 22]}}
{"token": ["GE-EPI", "measured", "a", "significant", "increase", "in", "C1428360#ent", "<e1>", "and", "CBV", "in", "response", "to", "C3889703#ent", "<e2>", ",", "while", "SE-EPI", "measured", "a", "significant", "increase", "in", "CBV", "and", "MTT", "."], "h": {"id": "C1428360", "name": "C1428360#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3889703", "name": "C3889703#ent", "pos": [13, 14]}}
{"token": ["Endo-beta-N-acetylglucosaminidase", "H", "C0014175#ent", "<e1>", ",", "an", "endoglycosidase", "secreted", "by", "Streptomyces", "plicatus", "hydrolyzes", "the", "C0007158#ent", "<e2>", "the", "core", "N-acetyglucosamine", "residues", "of", "asparagine-linked", "high-mannose", "oligosaccharides", "."], "h": {"id": "C0014175", "name": "C0014175#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0007158", "name": "C0007158#ent", "pos": [13, 14]}}
{"token": ["We", "identified", "an", "C0079941#ent", "<e1>", "a", "putative", "C0394005#ent", "<e2>", "in", "the", "b0968", "Escherichia", "coli", "gene", "and", "purified", "the", "recombinant", "enzyme", "after", "checking", "by", "RT-PCR", "that", "it", "was", "indeed", "expressed", "."], "h": {"id": "C0079941", "name": "C0079941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0394005", "name": "C0394005#ent", "pos": [7, 8]}}
{"token": ["We", "previously", "showed", "that", "suppression", "of", "C0086661#ent", "<e1>", "is", "a", "critical", "step", "in", "glucocorticoid-induced", "cell", "lysis", "C1706327#ent", "<e2>"], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1706327", "name": "C1706327#ent", "pos": [16, 17]}}
{"token": ["C0065432#ent", "<e1>", "suppressed", "the", "contractile", "responses", "1", "microM", "C0006945#ent", "<e2>", "and", "potentiated", "the", "response", "to", "high", "concentrations", "."], "h": {"id": "C0065432", "name": "C0065432#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0006945", "name": "C0006945#ent", "pos": [8, 9]}}
{"token": ["Furthermore", ",", "ERK", "inhibitors", "U0126", "and", "C0298346#ent", "<e1>", ")", "suppressed", "LPA-stimulated", "activation", "of", "NF-kappaB", "and", "C1420556#ent", "<e2>", "phosphorylation", "whereas", "wortmannin", "showed", "no", "effect", "NF-kappaB", "activation"], "h": {"id": "C0298346", "name": "C0298346#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420556", "name": "C1420556#ent", "pos": [15, 16]}}
{"token": ["Frentizole", ",", "lamprene", ",", "intal", "and", "C0733383#ent", "<e1>", "but", "not", "C0010980#ent", "<e2>", "enhanced", "phagocytosis", "in", "the", "presence", "of", "serum", "."], "h": {"id": "C0733383", "name": "C0733383#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0010980", "name": "C0010980#ent", "pos": [10, 11]}}
{"token": ["The", "peptide", "autoepitopes", "also", "triggered", "the", "pathogenic", "Th", "cells", "(", "SWR", "x", "NZB)F1", "C0024131#ent", "<e1>", "mice", "in", "vivo", "induce", "the", "development", "of", "severe", "C4053959#ent", "<e2>"], "h": {"id": "C0024131", "name": "C0024131#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C4053959", "name": "C4053959#ent", "pos": [23, 24]}}
{"token": ["Thrombotic", "microangiopathy", "C3854173#ent", "<e1>", "cardinal", "features", "of", "C1268936#ent", "<e2>", "HUS", ")", "."], "h": {"id": "C3854173", "name": "C3854173#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1268936", "name": "C1268936#ent", "pos": [7, 8]}}
{"token": ["Effects", "of", "vitamin", "E", "V.E", ")", "and", "C0003969#ent", "<e1>", "the", "progress", "of", "C0023896#ent", "<e2>", "72", "Osteogenic", "Disorder", "Shionogi", "(", "ODS", ")", "male", "rats", "were", "studied", "."], "h": {"id": "C0003969", "name": "C0003969#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0023896", "name": "C0023896#ent", "pos": [12, 13]}}
{"token": ["The", "addition", "of", "C1418941#ent", "<e1>", "does", "not", "significantly", "affect", "C1826354#ent", "<e2>", "activity", "."], "h": {"id": "C1418941", "name": "C1418941#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1826354", "name": "C1826354#ent", "pos": [9, 10]}}
{"token": ["Because", "of", "the", "central", "role", "of", "protein", "synthesis", "we", "have", "investigated", "the", "involvement", "of", "C1705451#ent", "<e1>", ",", "which", "is", "inhibited", "as", "a", "result", "of", "C4283740#ent", "<e2>", "phosphorylation", ",", "in", "programmed", "cell", "death"], "h": {"id": "C1705451", "name": "C1705451#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C4283740", "name": "C4283740#ent", "pos": [24, 25]}}
{"token": ["The", "study", "suggests", "that", "C0700541#ent", "<e1>", "is", "a", "good", "alternative", "to", "C0220791#ent", "<e2>", "as", "an", "induction", "agent", "caesarean", "section"], "h": {"id": "C0700541", "name": "C0700541#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0220791", "name": "C0220791#ent", "pos": [11, 12]}}
{"token": ["C0063041#ent", "<e1>", "diminished", "the", "tyrosine", "phosphorylation", "JAK3", "and", "C1335877#ent", "<e2>", "in", "the", "absence", "or", "presence", "of", "uridine", "."], "h": {"id": "C0063041", "name": "C0063041#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1335877", "name": "C1335877#ent", "pos": [8, 9]}}
{"token": ["Guanine", "nucleotide", "exchange", "factors", "GEFs", ")", "have", "been", "implicated", "in", "growth", "C1705592#ent", "<e1>", "neuronal", "differentiation", "through", "the", "activation", "of", "C0751984#ent", "<e2>"], "h": {"id": "C1705592", "name": "C1705592#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0751984", "name": "C0751984#ent", "pos": [19, 20]}}
{"token": ["A", "recent", "ex", "vivo", "study", "suggests", "that", "the", "metabolic", "activation", "of", "clopidogrel", "is", "catalyzed", "by", "cytochrom", "P450", "CYP", ")", "C1142644#ent", "<e1>", "and", "is", "competitively", "inhibited", "by", "C2698196#ent", "<e2>", ",", "but", "not", "pravastatin", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [19, 20]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C2698196", "name": "C2698196#ent", "pos": [26, 27]}}
{"token": ["First", "it", "allows", "a", "differentiation", "between", "C0011860#ent", "<e1>", "IDD", ")", "and", "non", "insulin", "dependent", "C0795956#ent", "<e2>", ")", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0795956", "name": "C0795956#ent", "pos": [14, 15]}}
{"token": ["The", "intracellular", "C1705556#ent", "<e1>", "in", "monocytes", "was", "decreased", "in", "C0263361#ent", "<e2>", "compared", "with", "the", "controls", "."], "h": {"id": "C1705556", "name": "C1705556#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0263361", "name": "C0263361#ent", "pos": [9, 10]}}
{"token": ["Specificity", ",", "established", "in", "controls", "and", "49", "patients", "with", "different", "C0017178#ent", "<e1>", "was", "77", "%", "for", "elastase", "1", "76", "%", "for", "immunoreactive", "C0041236#ent", "<e2>", ",", "83", "%", "for", "pancreatic", "lipase", "91", "%", "for", "pancreatic", "amylase"], "h": {"id": "C0017178", "name": "C0017178#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0041236", "name": "C0041236#ent", "pos": [22, 23]}}
{"token": ["Exposing", "C0872351#ent", "<e1>", "of", "human", "umbilical", "vein", "endothelial", "cells", "HUVECs", ")", "to", "recombinant", "human", "C1705079#ent", "<e2>", "(", "rhMCP-1", ")", "or", "to", "the", "culture", "supernatant", "DV2-infected", "human", "monocytes", "increased", "the", "vascular", "permeability", "the", "cells", "."], "h": {"id": "C0872351", "name": "C0872351#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1705079", "name": "C1705079#ent", "pos": [14, 15]}}
{"token": ["Antacids", ",", "such", "as", "C2930042#ent", "<e1>", "AIMg(OH)3", ")", ",", "or", "H2-receptor", "antagonists", ",", "such", "as", "C0034665#ent", "<e2>", ",", "are", "common", "drugs", "used", "for", "treating", "peptic", "ulcer", "disease", "acid-related", "symptoms", "."], "h": {"id": "C2930042", "name": "C2930042#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034665", "name": "C0034665#ent", "pos": [15, 16]}}
{"token": ["Diffuse", "CMV", "colitis", "present", "in", "eight", "patients", ",", "C0014335#ent", "<e1>", "in", "seven", ",", "esophagitis", "in", "four", ",", "C0563238#ent", "<e2>", "in", "two", ",", "cholangitis", "in", "one", ",", "and", "acute", "pancreatitis", "one", "."], "h": {"id": "C0014335", "name": "C0014335#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0563238", "name": "C0563238#ent", "pos": [17, 18]}}
{"token": ["It", "has", "been", "shown", "that", "some", "C0169101#ent", "<e1>", "such", "as", "the", "c-Jun", "N-terminal", "kinase", "the", "C3849574#ent", "<e2>", ",", "play", "important", "roles", "in", "the", "regulation", "of", "7alpha-hydroxylase", "transcription", "."], "h": {"id": "C0169101", "name": "C0169101#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C3849574", "name": "C3849574#ent", "pos": [15, 16]}}
{"token": ["Antiandrogens", "result", "in", "protection", "of", "both", "the", "hinge", "region", "C-terminus", "of", "androgen", "receptor", "proteolytic", "attack", "whereas", "other", "studies", "showed", "that", "antiestrogens", "and", "C1510932#ent", "<e1>", "expose", "the", "C-terminal", "end", "the", "ligand", "binding", "domain", "their", "respective", "receptors", "to", "C0030946#ent", "<e2>", "."], "h": {"id": "C1510932", "name": "C1510932#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0030946", "name": "C0030946#ent", "pos": [36, 37]}}
{"token": ["The", "use", "of", "probes", "selective", "for", "C0812287#ent", "<e1>", "N-myc", "1", "the", "normal", "mammalian", "C1334043#ent", "<e2>", ")", "revealed", "nearly", "exclusive", "expression", "of", "C0812287#ent", "<e1>", "AHFs", "."], "h": {"id": "C0812287", "name": "C0812287#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1334043", "name": "C1334043#ent", "pos": [13, 14]}}
{"token": ["We", "tested", "the", "hypothesis", "that", "low", "urinary", "C1705396#ent", "<e1>", "levels", "may", "predispose", "to", "C0262655#ent", "<e2>", "UTI", ")", "by", "measuring", "C1705396#ent", "<e1>", "levels", "in", "children", "."], "h": {"id": "C1705396", "name": "C1705396#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0262655", "name": "C0262655#ent", "pos": [13, 14]}}
{"token": ["Before", "virulent", "challenge", ",", "BCG", "vaccination", "clearly", "enhanced", "the", "ability", "of", "BALC", ",", "C1418724#ent", "<e1>", "and", "SPC", "to", "produce", "C1710304#ent", "<e2>", "in", "response", "to", "PPD", "stimulation", "ex", "vivo"], "h": {"id": "C1418724", "name": "C1418724#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [19, 20]}}
{"token": ["The", "TATA-less", "murine", "C0026267#ent", "<e1>", "and", "human", "C0042291#ent", "<e2>", "promoters", "were", "identified", "and", "functionally", "characterized", "."], "h": {"id": "C0026267", "name": "C0026267#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0042291", "name": "C0042291#ent", "pos": [7, 8]}}
{"token": ["Amongst", "H2", "receptor", "antagonists", "the", "more", "long-acting", "compounds", ",", "ranitidine", "and", "C0015620#ent", "<e1>", ",", "will", "improve", "C0018834#ent", "<e2>", "control", "througho"], "h": {"id": "C0015620", "name": "C0015620#ent", "pos": [11, 12]}, "relation": "may_treat", "t": {"id": "C0018834", "name": "C0018834#ent", "pos": [16, 17]}}
{"token": ["It", "seems", "unlikely", "that", "the", "antianginal", "activity", "of", "C0012367#ent", "<e1>", "can", "be", "fully", "explained", "by", "its", "weak", "C0006684#ent", "<e2>", "potency", "."], "h": {"id": "C0012367", "name": "C0012367#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [17, 18]}}
{"token": ["C1417784#ent", "<e1>", "expression", "is", "frequently", "decreased", "in", "C2974542#ent", "<e2>", "patients", "."], "h": {"id": "C1417784", "name": "C1417784#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2974542", "name": "C2974542#ent", "pos": [7, 8]}}
{"token": ["We", "have", "recently", "shown", "that", "the", "C1413827#ent", "<e1>", "transcription", "factor", "proteolytically", "processed", "at", "the", "G(1)/S", "transition", "by", "the", "C1332807#ent", "<e2>"], "h": {"id": "C1413827", "name": "C1413827#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1332807", "name": "C1332807#ent", "pos": [18, 19]}}
{"token": ["Acceptor", "substrate", "specificities", "of", "C3887936#ent", "<e1>", "and", "-T6", "were", "similar", "and", "different", "from", "other", "C0077730#ent", "<e2>", "."], "h": {"id": "C3887936", "name": "C3887936#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0077730", "name": "C0077730#ent", "pos": [14, 15]}}
{"token": ["We", "assessed", "the", "C0003374#ent", "<e1>", "and", "antischistosomal", "efficacies", "of", "C0052429#ent", "<e2>", "in", "mice", "infected", "with", "Plasmodium", "berghei", "Schistosoma", "mansoni", "both", "parasites", "concurrently", "."], "h": {"id": "C0003374", "name": "C0003374#ent", "pos": [3, 4]}, "relation": "therapeutic_class_of", "t": {"id": "C0052429", "name": "C0052429#ent", "pos": [9, 10]}}
{"token": ["The", "role", "of", "C1434623#ent", "<e1>", "(", "S1P", ")", "receptors", "in", "acute", "vascular", "injury", "smooth", "muscle", "cell", "C1539322#ent", "<e2>", ")", "phenotypic", "modulation", "is", "not", "completely", "resolved", "."], "h": {"id": "C1434623", "name": "C1434623#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539322", "name": "C1539322#ent", "pos": [16, 17]}}
{"token": ["The", "purpose", "of", "this", "study", "was", "to", "examine", "the", "beneficial", "effects", "of", "C0637063#ent", "<e1>", "on", "lipopolysaccharide", "(LPS)-induced", "C3714636#ent", "<e2>"], "h": {"id": "C0637063", "name": "C0637063#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C3714636", "name": "C3714636#ent", "pos": [17, 18]}}
{"token": ["Eight", "patients", "who", "became", "ill", "while", "taking", "tryptophan", "had", "myalgia", ",", "fatigue", ",", "rash", ",", "fever", ",", "edema", ",", "C0002170#ent", "<e1>", ",", "arthralgias", ",", "diminished", "joint", "motion", "skin", "tightening", "C0338467#ent", "<e2>", "and", "distal", "paresthesias"], "h": {"id": "C0002170", "name": "C0002170#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0338467", "name": "C0338467#ent", "pos": [29, 30]}}
{"token": ["We", "conclude", "that", "a", "significant", "component", "of", "C4048300#ent", "<e1>", "malfunction", "in", "C1421250#ent", "<e2>", "results", "from", "their", "retention", "and", "degradation", "in", "the", "ER", "compartment", "."], "h": {"id": "C4048300", "name": "C4048300#ent", "pos": [7, 8]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421250", "name": "C1421250#ent", "pos": [11, 12]}}
{"token": ["Another", "protein", "associated", "only", "with", "epitope-tagged", "temperature-sensitive", "(", "Rne-3071", ")", "mutant", "C0073237#ent", "<e1>", "not", "with", "the", "wild-type", "enzyme", "is", "C3538704#ent", "<e2>", "."], "h": {"id": "C0073237", "name": "C0073237#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3538704", "name": "C3538704#ent", "pos": [19, 20]}}
{"token": ["AtT-20", "cells", "synthesize", "87", "kDa", "and", "66", "kDa", "forms", "of", "the", "C1258132#ent", "<e1>", "PC3", "(", "also", "known", "as", "C1414407#ent", "<e2>", ")", "."], "h": {"id": "C1258132", "name": "C1258132#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1414407", "name": "C1414407#ent", "pos": [18, 19]}}
{"token": ["However", ",", "the", "occurrence", "of", "major", "C0042291#ent", "<e1>", ",", "significantly", "higher", "patients", "with", "documented", "C2987167#ent", "<e2>", ",", "including", "in", "asymptomatic", "patients", ",", "mandates", "the", "performance", "under", "appropriate", "medical", "supervision"], "h": {"id": "C0042291", "name": "C0042291#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2987167", "name": "C2987167#ent", "pos": [14, 15]}}
{"token": ["It", "differs", "from", "other", "C1705280#ent", "<e1>", "GAPs", "in", "its", "covalent", "association", "the", "C1528775#ent", "<e2>", "its", "specificity", "for", "the", "ARF", "domain", "ARD1", "."], "h": {"id": "C1705280", "name": "C1705280#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1528775", "name": "C1528775#ent", "pos": [12, 13]}}
{"token": ["To", "test", "how", "the", "Rb", "pathway", "with", "other", "pathways", "in", "tumor", "suppression", "we", "characterized", "mice", "with", "mutations", "in", "both", "the", "C0243045#ent", "<e1>", "CDK", ")", "inhibitor", "p18", "Ink4c", "the", "lipid", "phosphatase", "C0694888#ent", "<e2>", ",", "which", "regulates", "cell", "growth"], "h": {"id": "C0243045", "name": "C0243045#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0694888", "name": "C0694888#ent", "pos": [30, 31]}}
{"token": ["C1823700#ent", "<e1>", "significantly", "decreased", "extracellular", "C0017789#ent", "<e2>", "but", "not", "aspartate", "concentrations", "and", "significantly", "attenuated", "the", "development", "of", "mechanical", "but", "not", "thermal", "allodynia"], "h": {"id": "C1823700", "name": "C1823700#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0017789", "name": "C0017789#ent", "pos": [5, 6]}}
{"token": ["These", "findings", "establish", "the", "aberrant", "expression", "and", "distribution", "of", "C1417836#ent", "<e1>", "in", "psoriasis", "and", "suggest", "that", "clinical", "benefits", "C1710304#ent", "<e2>", "inhibition", "may", "be", "mediated", "through", "altered", "C1417836#ent", "<e1>", "activity", "."], "h": {"id": "C1417836", "name": "C1417836#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1710304", "name": "C1710304#ent", "pos": [18, 19]}}
{"token": ["Manganese", "poisoning", "cause", "C0234132#ent", "<e1>", "as", "parkinsonism", ",", "C0013421#ent", "<e2>", "and", "chorea", "."], "h": {"id": "C0234132", "name": "C0234132#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013421", "name": "C0013421#ent", "pos": [8, 9]}}
{"token": ["This", "study", "examined", "the", "effect", "of", "gliclazide", "on", "tissue-type", "plasminogen", "activator", "fibrinolysis", "in", "23", "C0011860#ent", "<e1>", "patients", "without", "residual", "beta-cell", "function", "17", "Type", "II", "diabetic", "patients", "initially", "treated", "with", "C0040374#ent", "<e2>", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [14, 15]}, "relation": "may_be_treated_by", "t": {"id": "C0040374", "name": "C0040374#ent", "pos": [29, 30]}}
{"token": ["Eleven", "days", "after", "the", "injection", "of", "M-Hb", ",", "other", "groups", "of", "rats", "received", "another", "equal", "dose", "of", "the", "C1254351#ent", "<e1>", "in", "order", "to", "induce", "a", "second", "episode", "of", "C1424611#ent", "<e2>", "."], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1424611", "name": "C1424611#ent", "pos": [28, 29]}}
{"token": ["Taken", "together", ",", "adenosine", "not", "only", "inhibits", "the", "spontaneous", "release", "of", "C0017789#ent", "<e1>", "independently", "of", "C0033640#ent", "<e2>", "C", "but", "also", "reverses", "the", "enhancement", "of", "exocytosis", "produced", "by", "C0033640#ent", "<e2>", "C", "activators"], "h": {"id": "C0017789", "name": "C0017789#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0033640", "name": "C0033640#ent", "pos": [15, 16]}}
{"token": ["Cases", "included", "Alzheimer", "disease", "Pick", "disease", "progressive", "supranuclear", "palsy", "corticobasal", "degeneration", "C0017495#ent", "<e1>", "disease-Indiana", "kindred", ",", "and", "frontotemporal", "dementia", "C0242422#ent", "<e2>", "linked", "to", "chromosome", "17"], "h": {"id": "C0017495", "name": "C0017495#ent", "pos": [11, 12]}, "relation": "has_manifestation", "t": {"id": "C0242422", "name": "C0242422#ent", "pos": [19, 20]}}
{"token": ["We", "report", "our", "observations", "of", "ketotic", "hypoglycaemia", "six", "children", "who", "were", "born", "with", "IUGR", "and", "developed", "hyperinsulinaemic", "hypoglycaemia", "C0062941#ent", "<e1>", ")", "that", "required", "treatment", "with", "C0012022#ent", "<e2>", "and", "chlorothiazide", "."], "h": {"id": "C0062941", "name": "C0062941#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0012022", "name": "C0012022#ent", "pos": [25, 26]}}
{"token": ["Lef-1/beta-cat", "stimulated", "expression", "of", "a", "known", "beta-catenin", "target", "(", "C0694872#ent", "<e1>", ")", ",", "suppressed", "expression", "of", "Apc", "and", "C1332125#ent", "<e2>", ",", "and", "induced", "apoptosis", "in", "129/Sv", "but", "not", "in", "neighboring", "B6-ROSA26", "epithelial", "cells"], "h": {"id": "C0694872", "name": "C0694872#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1332125", "name": "C1332125#ent", "pos": [18, 19]}}
{"token": ["Although", "prompt", "treatment", "with", "C0070895#ent", "<e1>", "stabilized", "encephalitis", "and", "there", "were", "no", "serious", "neurological", "sequelae", "the", "patient", "developed", "both", "C0020625#ent", "<e2>", "and", "natriuresis", "11", "days", "after", "intravenous", "administration", "C0070895#ent", "<e1>", "."], "h": {"id": "C0020625", "name": "C0020625#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0070895", "name": "C0070895#ent", "pos": [4, 5]}}
{"token": ["Furthermore", ",", "mice", "lacking", "the", "C1823135#ent", "<e1>", "highly", "susceptible", "to", "C0003850#ent", "<e2>", "and", "to", "OP", "poisoning"], "h": {"id": "C1823135", "name": "C1823135#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0003850", "name": "C0003850#ent", "pos": [10, 11]}}
{"token": ["We", "concluded", "that", "C1414504#ent", "<e1>", "can", "regulate", "the", "growth", ",", "C1539078#ent", "<e2>", "and", "functional", "reorganization", "of", "the", "pulp", "tissue", "pulp", "healing", "and", "inflammatory", "processes"], "h": {"id": "C1414504", "name": "C1414504#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1539078", "name": "C1539078#ent", "pos": [10, 11]}}
{"token": ["Combined", "therapy", "C1962523#ent", "<e1>", "did", "not", "attenuate", "the", "sympathetic", "activation", "induced", "by", "C0051696#ent", "<e2>", "."], "h": {"id": "C1962523", "name": "C1962523#ent", "pos": [2, 3]}, "relation": "has_constitutional_part", "t": {"id": "C0051696", "name": "C0051696#ent", "pos": [12, 13]}}
{"token": ["After", "transplantation", ",", "the", "patient", "developed", "C0018133#ent", "<e1>", "and", "was", "given", "methylprednisolone", ",", "cyclosporin", "and", "C0209368#ent", "<e2>"], "h": {"id": "C0018133", "name": "C0018133#ent", "pos": [6, 7]}, "relation": "may_be_treated_by", "t": {"id": "C0209368", "name": "C0209368#ent", "pos": [15, 16]}}
{"token": ["The", "transfectants", "of", "SC", "115", "with", "C0919466#ent", "<e1>", "still", "retained", "C0039585#ent", "<e2>", "growth", ",", "although", "the", "cells", "could", "grow", "without", "androgen", "."], "h": {"id": "C0919466", "name": "C0919466#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0039585", "name": "C0039585#ent", "pos": [10, 11]}}
{"token": ["A", "cohort", "study", "guests", "of", "the", "suspect", "hotel", "revealed", "23", "cases", "of", "C0009952#ent", "<e1>", "illness", "with", "C1457887#ent", "<e2>", "significant", "antibody", "titers", "to", "Legionella", "pneumophila", "or", "both", ",", "among", "291", "persons", "at", "risk", "."], "h": {"id": "C0009952", "name": "C0009952#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1457887", "name": "C1457887#ent", "pos": [16, 17]}}
{"token": ["The", "overall", "prevalence", "of", "pulmonary", "arterial", "hypertension", "this", "population", "of", "patients", "with", "progressive", "C0036421#ent", "<e1>", "33", "percent", ",", "and", "among", "10", "subjects", "with", "the", "C0206138#ent", "<e2>", "prevalence", "of", "pulmonary", "hypertension", "50", "percent", "."], "h": {"id": "C0036421", "name": "C0036421#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0206138", "name": "C0206138#ent", "pos": [24, 25]}}
{"token": ["This", "long", "term", "maintenance", "of", "Ag-specific", "reactivity", "in", "the", "allergic", "response", "also", "observed", "in", "normal", "mice", "sensitized", "with", "C1415975#ent", "<e1>", "even", "though", "the", "C2926735#ent", "<e2>", "was", "shorter", "than", "that", "in", "B", "cell-deficient", "mice", "."], "h": {"id": "C1415975", "name": "C1415975#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [23, 24]}}
{"token": ["Pretreatment", "with", "HQL-79", ",", "an", "inhibitor", "of", "C0072296#ent", "<e1>", "abolished", "LTC4", "synthesis", "and", "C1306759#ent", "<e2>", "lipid", "body", "triggered", "by", "allergic", "challenge", "."], "h": {"id": "C0072296", "name": "C0072296#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1306759", "name": "C1306759#ent", "pos": [13, 14]}}
{"token": ["By", "diverting", "2-amino", "3-carboxymuconate", "semialdehyde", "from", "quinolinate", "production", ",", "the", "C0014442#ent", "<e1>", "regulates", "NAD", "biosynthesis", "the", "amino", "acid", "directly", "affecting", "quinolinate", "and", "C0137028#ent", "<e2>", "formation", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0137028", "name": "C0137028#ent", "pos": [22, 23]}}
{"token": ["These", "observations", ",", "which", "suggest", "an", "C0011860#ent", "<e1>", "involvement", "of", "a", "C0031671#ent", "<e2>", "are", "strengthened", "by", "the", "increase", "of", "PC-derived", "phosphatidylethanol", "in", "presence", "of", "ethanol", "."], "h": {"id": "C0011860", "name": "C0011860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031671", "name": "C0031671#ent", "pos": [11, 12]}}
{"token": ["However", ",", "increased", "numbers", "of", "organelles", "in", "expanded", "perikarya", "and", "large", "processes", "occurred", "after", "C0025649#ent", "<e1>", "treatment", "with", "and", "without", "C0718495#ent", "<e2>", "infusion", "."], "h": {"id": "C0025649", "name": "C0025649#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0718495", "name": "C0718495#ent", "pos": [20, 21]}}
{"token": ["Estrogen", "decreased", "noradrenaline", "turnover", "in", "C0001614#ent", "<e1>", "and", "brain", "stem", "C2757070#ent", "<e2>", "enhanced", "this", "effect", "in", "brain", "stem", "prevented", "it", "in", "C0001614#ent", "<e1>", "."], "h": {"id": "C2757070", "name": "C2757070#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0001614", "name": "C0001614#ent", "pos": [5, 6]}}
{"token": ["In", "the", "C1313497#ent", "<e1>", "calculation", "with", "spin-orbit", "terms", ",", "the", "D3h", "structure", "C3542399#ent", "<e2>", "is", "a", "second-order", "saddle", "point", "."], "h": {"id": "C1313497", "name": "C1313497#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3542399", "name": "C3542399#ent", "pos": [12, 13]}}
{"token": ["Linsidomine", "or", "SIN-1", ",", "a", "C0042402#ent", "<e1>", "of", "epicardial", "arteries", ",", "is", "the", "active", "metabolite", "C0026400#ent", "<e2>", "which", "is", "regularly", "used", "for", "intracoronary", "injection", "."], "h": {"id": "C0042402", "name": "C0042402#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0026400", "name": "C0026400#ent", "pos": [15, 16]}}
{"token": ["Thus", "these", "data", "indicate", "that", "patients", "with", "C0018802#ent", "<e1>", "can", "receive", "C0118168#ent", "<e2>", "without", "undue", "increases", "in", "fosinoprilat", "concentrations"], "h": {"id": "C0018802", "name": "C0018802#ent", "pos": [7, 8]}, "relation": "may_be_treated_by", "t": {"id": "C0118168", "name": "C0118168#ent", "pos": [11, 12]}}
{"token": ["The", "kinetic", "constants", "for", "sodium-PZA", "cotransport", "were", "measured", "under", "initial", "linear", "flux", "zero", "C0013447#ent", "<e1>", "both", "sodium", "and", "C0280970#ent", "<e2>", "."], "h": {"id": "C0013447", "name": "C0013447#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0280970", "name": "C0280970#ent", "pos": [18, 19]}}
{"token": ["Second", ",", "consistent", "with", "cerebellar", "feature", "of", "the", "C0028850#ent", "<e1>", "a", "major", "C0087140#ent", "<e2>", "expression", "was", "found", "in", "the", "cerebellar", "circuitry", "(", "deep", "cerebellar", "nuclei", "pontine", "nuclei", "vestibular", "complex", "and", "inferior", "olive", "."], "h": {"id": "C0028850", "name": "C0028850#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0087140", "name": "C0087140#ent", "pos": [12, 13]}}
{"token": ["In", "fact", ",", "chimeric", "C0014442#ent", "<e1>", "containing", "the", "amino-terminal", "portion", "ST8Sia", "IV", "to", "downstream", "sequences", "of", "C0298692#ent", "<e2>", "inhibited", "NCAM", "polysialylation", "in", "vitro", "although", "they", "did", "not", "polysialylate", "NCAM", "."], "h": {"id": "C0014442", "name": "C0014442#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0298692", "name": "C0298692#ent", "pos": [16, 17]}}
{"token": ["Moreover", ",", "it", "is", "known", "that", "C0752312#ent", "<e1>", "capable", "of", "phosphorylating", "other", "mitogen-inducible", "transcription", "factors", "e.g.", ",", "Elk", ",", "C1456795#ent", "<e2>", "suggesting", "that", "Erk", "may", "also", "inducibly", "phosphorylate", "Sp1", "."], "h": {"id": "C0752312", "name": "C0752312#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1456795", "name": "C1456795#ent", "pos": [19, 20]}}
{"token": ["Mutations", "in", "C1364081#ent", "<e1>", "have", "also", "been", "described", "in", "patients", "with", "C0035334#ent", "<e2>", "RP", ")", "."], "h": {"id": "C1364081", "name": "C1364081#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0035334", "name": "C0035334#ent", "pos": [11, 12]}}
{"token": ["C0623362#ent", "<e1>", "MMPs", ")", "are", "overexpressed", "in", "the", "presence", "of", "some", "C0027765#ent", "<e2>", "which", "blood-brain", "barrier", "disruption", "exists", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027765", "name": "C0027765#ent", "pos": [11, 12]}}
{"token": ["Simultaneously", "to", "these", "electrophysiological", "effects", "C0766326#ent", "<e1>", "reduced", "contraction", "amplitudes", "of", "papillary", "muscle", "decreased", "C1413043#ent", "<e2>", "+", "transient", "and", "shortening", "of", "ventricular", "myocytes"], "h": {"id": "C0766326", "name": "C0766326#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413043", "name": "C1413043#ent", "pos": [14, 15]}}
{"token": ["While", "the", "implications", "of", "these", "results", "for", "human", "physiology", "require", "further", "studies", ",", "they", "suggest", "that", "male", "C0020619#ent", "<e1>", "may", "play", "a", "role", "in", "determining", "the", "risk", "of", "C0007222#ent", "<e2>", "diabetes", "."], "h": {"id": "C0020619", "name": "C0020619#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0007222", "name": "C0007222#ent", "pos": [28, 29]}}
{"token": ["Phages", "phi", "29", "C1425046#ent", "<e1>", "and", "SPO2c12", "or", "their", "C0011519#ent", "<e2>", "were", "irradiated", "by", "UVC", "(", "254", "nm", ")", "and", "quantum", "yields", "for", "inactivation", "were", "calculated", "."], "h": {"id": "C1425046", "name": "C1425046#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0011519", "name": "C0011519#ent", "pos": [9, 10]}}
{"token": ["Our", "previous", "studies", "implicated", "a", "structural", "and", "functional", "activity", "of", "the", "C1364818#ent", "<e1>", "family", "of", "proteins", "in", "the", "developing", "C0751950#ent", "<e2>", "NMJ", ")", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0751950", "name": "C0751950#ent", "pos": [19, 20]}}
{"token": ["The", "mucosal", "cytoprotector", "effect", "of", "sucralfate", ",", "misoprostol", ",", "C0085191#ent", "<e1>", ",", "cimetidine", ",", "ranitidine", ",", "C0600832#ent", "<e2>", "and", "10", "%", "aluminum", "sulphate", "almost", "complete", "macroscopic", "and", "histological", "protection", "to", "the", "gastric", "mucosa"], "h": {"id": "C0085191", "name": "C0085191#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0600832", "name": "C0600832#ent", "pos": [16, 17]}}
{"token": ["We", "have", "described", "a", "mobilisation", "regimen", "7", "days", "of", "C0020402#ent", "<e1>", "followed", "by", "C1705750#ent", "<e2>", "and", "have", "shown", "it", "to", "be", "substantially", "less", "toxic", "than", "other", "methods", "."], "h": {"id": "C0020402", "name": "C0020402#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705750", "name": "C1705750#ent", "pos": [13, 14]}}
{"token": ["NE-stimulated", "C0388638#ent", "<e1>", "activity", "was", "attenuated", "by", "C0138837#ent", "<e2>", "FPT", "III", "and", "SCH-56582", ")", ",", "which", "reduce", "activation", "of", "both", "Ras", "and", "mitogen-activated", "protein", "MAP", ")", "kinase", "."], "h": {"id": "C0388638", "name": "C0388638#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0138837", "name": "C0138837#ent", "pos": [7, 8]}}
{"token": ["Recent", "successes", "in", "the", "isolation", "of", "C0085249#ent", "<e1>", "their", "modification", "C1333402#ent", "<e2>", "enabled", "clearer", "demonstrations", "of", "the", "roles", "of", "complex", "carbohydrates"], "h": {"id": "C0085249", "name": "C0085249#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333402", "name": "C1333402#ent", "pos": [10, 11]}}
{"token": ["One", "complained", "of", "C0019559#ent", "<e1>", "and", "the", "other", "felt", "C0235318#ent", "<e2>"], "h": {"id": "C0019559", "name": "C0019559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0235318", "name": "C0235318#ent", "pos": [9, 10]}}
{"token": ["Provision", "of", "just", "1", "%", "dietary", "calcium", "C3710848#ent", "<e1>", "attenuated", "hypertension", "without", "inducing", "impaired", "weight", "gain", "C0020631#ent", "<e2>", "."], "h": {"id": "C3710848", "name": "C3710848#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0020631", "name": "C0020631#ent", "pos": [16, 17]}}
{"token": ["The", "C1512412#ent", "<e1>", "seen", "in", "these", "animal", "models", "the", "synthetic", "FXR", "agonist", "suggests", "C3889135#ent", "<e2>", "agonists", "may", "be", "useful", "in", "the", "treatment", "of", "cholestatic", "liver", "disease"], "h": {"id": "C1512412", "name": "C1512412#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C3889135", "name": "C3889135#ent", "pos": [13, 14]}}
{"token": ["None", "was", "serologically", "positive", "for", "C0039128#ent", "<e1>", "and", "had", "cryoglobulin", "and", "C0154254#ent", "<e2>", "."], "h": {"id": "C0039128", "name": "C0039128#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0154254", "name": "C0154254#ent", "pos": [11, 12]}}
{"token": ["(+)-Glaucine-induced", "contraction", "was", "reduced", "by", "indomethacin", ",", "C0733397#ent", "<e1>", "bisindolylmaleimide", "I", "abolished", "by", "verapamil", "and", "C0028066#ent", "<e2>", "."], "h": {"id": "C0733397", "name": "C0733397#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0028066", "name": "C0028066#ent", "pos": [15, 16]}}
{"token": ["PreproAM", ",", "calcitonin", "receptor-like", "receptor", "CRLR", ")", ",", "C1419254#ent", "<e1>", "RAMP", ")", "mRNA", ",", "HIF-1", "and", "peptidyl-glycine-amidating", "monooxygenase", "C2931826#ent", "<e2>", ")", "mRNA", "levels", "were", "measured", "by", "reverse", "transcription-polymerase", "chain", "reaction"], "h": {"id": "C1419254", "name": "C1419254#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2931826", "name": "C2931826#ent", "pos": [18, 19]}}
{"token": ["C3540801#ent", "<e1>", "extracted", "from", "red", "soybeans", "mostly", "C0056650#ent", "<e2>", "conjugated", "with", "glucose", "and", "rhamnose", ",", "whereas", "bioflavonoids", "of", "red", "beans", "C0056650#ent", "<e2>", "conjugated", "with", "rhamnose", "as", "revealed", "by", "thin-layer", "chromatogram"], "h": {"id": "C3540801", "name": "C3540801#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0056650", "name": "C0056650#ent", "pos": [7, 8]}}
{"token": ["Then", ",", "we", "studied", "the", "CT", "brain", "scans", "and", "after", "ACTH-Z", "therapy", "for", "infantile", "spasms", "C0270846#ent", "<e1>", "Lennox", "syndrome", "showed", "some", "relationship", "between", "apparent", "C0236642#ent", "<e2>", "the", "CT", "brain", "scans", "and", "ACTH-Z", "treatment", "."], "h": {"id": "C0270846", "name": "C0270846#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0236642", "name": "C0236642#ent", "pos": [24, 25]}}
{"token": ["These", "blood", "abnormalities", "C0240066#ent", "<e1>", "anemia", "with", "or", "without", "thrombocytosis", ",", "dysplasminogenia", ",", "C1264041#ent", "<e2>", "protein", "S", "deficiency", "protein", "C", "deficiency", "and", "abnormal", "platelet", "function"], "h": {"id": "C0240066", "name": "C0240066#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1264041", "name": "C1264041#ent", "pos": [13, 14]}}
{"token": ["C0024115#ent", "<e1>", "seen", "in", "4", "per", "cent", "of", "patients", "with", "C3714757#ent", "<e2>"], "h": {"id": "C0024115", "name": "C0024115#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3714757", "name": "C3714757#ent", "pos": [10, 11]}}
{"token": ["A", "C1333663#ent", "<e1>", "mutant", "defective", "in", "FOG-1", "binding", "occupied", "a", "C1416831#ent", "<e2>", "regulatory", "region", "levels", "higher", "than", "wild-type", "C1333663#ent", "<e1>", ",", "whereas", "FOG-1", "facilitated", "chromatin", "occupancy", "at", "a", "distinct", "target", "site", "."], "h": {"id": "C1416831", "name": "C1416831#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333663", "name": "C1333663#ent", "pos": [1, 2]}}
{"token": ["Mice", "deficient", "for", "neurotrophin-3", "(", "C1706578#ent", "<e1>", ")", "and", "its", "receptor", ",", "encoded", "by", "the", "C1704843#ent", "<e2>", "show", "abnormal", "movements", "caused", "by", "the", "loss", "of", "sensory", "proprioceptive", "neurons", "."], "h": {"id": "C1706578", "name": "C1706578#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1704843", "name": "C1704843#ent", "pos": [15, 16]}}
{"token": ["While", "little", "is", "known", "about", "C0085435#ent", "<e1>", "Campylobacter", "infection", "our", "knowledge", "on", "the", "pathogenesis", "of", "Campylobacter-induced", "C0018378#ent", "<e2>", "is", "expanding", "rapidly", "and", "is", "summarized", "in", "this", "review", "."], "h": {"id": "C0085435", "name": "C0085435#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0018378", "name": "C0018378#ent", "pos": [16, 17]}}
{"token": ["Long-term", "administration", "of", "C0030310#ent", "<e1>", "for", "ventilatory", "support", "adults", "with", "C0035222#ent", "<e2>", "may", "result", "in", "severe", "tetraparesis", ",", "with", "areflexia", "and", "atrophy", "of", "distal", "muscles"], "h": {"id": "C0030310", "name": "C0030310#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0035222", "name": "C0035222#ent", "pos": [10, 11]}}
{"token": ["We", "also", "investigated", "whether", "certain", "FPR", "haplotypes", "are", "associated", "with", "C0038013#ent", "<e1>", "RA", ")", "by", "sequencing", "C1333574#ent", "<e2>", "from", "148", "Caucasian", "individuals", "."], "h": {"id": "C0038013", "name": "C0038013#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1333574", "name": "C1333574#ent", "pos": [16, 17]}}
{"token": ["Active", "and", "direct", "passive", "C0003907#ent", "<e1>", "not", "develop", "or", "were", "extremely", "mild", "in", "such", "C1412999#ent", "<e2>", "inactivator-treated", "animals", "as", "judged", "by", "gross", "and", "histological", "observation", "."], "h": {"id": "C0003907", "name": "C0003907#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1412999", "name": "C1412999#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "C0534191#ent", "<e1>", "may", "be", "useful", "in", "serious", "bleeding", "complications", "in", "C1433124#ent", "<e2>", "treated", "patients", "."], "h": {"id": "C0534191", "name": "C0534191#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1433124", "name": "C1433124#ent", "pos": [14, 15]}}
{"token": ["Although", "FS", "and", "overlap", "of", "FS/GBS", "have", "been", "reported", "to", "be", "associated", "with", "C1538738#ent", "<e1>", "of", "C.", "jejuni", ",", "the", "C1875400#ent", "<e2>", "from", "our", "case", "belonged", "to", "PEN", "19", "."], "h": {"id": "C1538738", "name": "C1538738#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1875400", "name": "C1875400#ent", "pos": [20, 21]}}
{"token": ["A", "case", "of", "a", "51-year-old", "man", "admitted", "to", "the", "hospital", "for", "C0019079#ent", "<e1>", "after", "a", "three-week", "history", "of", "fever", "and", "C0010200#ent", "<e2>", "is", "presented", "."], "h": {"id": "C0019079", "name": "C0019079#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0010200", "name": "C0010200#ent", "pos": [20, 21]}}
{"token": ["We", "have", "examined", "the", "phosphorylation", "of", "the", "C0072402#ent", "<e1>", "the", "product", "of", "c-raf", "C0033713#ent", "<e2>", "in", "response", "to", "insulin", "or", "platelet-derived", "growth", "factor", "intact", "cells", "."], "h": {"id": "C0072402", "name": "C0072402#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0033713", "name": "C0033713#ent", "pos": [13, 14]}}
{"token": ["To", "present", "a", "case", "of", "severe", "drop", "in", "vision", "in", "both", "eyes", "caused", "by", "C1275499#ent", "<e1>", "was", "treated", "with", "intravitreal", "injection", "of", "C0040866#ent", "<e2>"], "h": {"id": "C1275499", "name": "C1275499#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040866", "name": "C0040866#ent", "pos": [22, 23]}}
{"token": ["In", "contrast", ",", "overexpression", "of", "C1414625#ent", "<e1>", "had", "no", "effect", "sensitivity", "to", "either", "C0013227#ent", "<e2>", "."], "h": {"id": "C1414625", "name": "C1414625#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [13, 14]}}
{"token": ["A", "screen-printed", "three-electrode", "amperometric", "biosensor", "incorporating", "C0065558#ent", "<e1>", "the", "measurement", "of", "C2827428#ent", "<e2>", "apple", ",", "potato", "and", "tomato", "horticultural", "samples", "has", "been", "developed", "."], "h": {"id": "C0065558", "name": "C0065558#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2827428", "name": "C2827428#ent", "pos": [11, 12]}}
{"token": ["Because", "DEC1", "and", "C1424440#ent", "<e1>", "are", "directly", "inducible", "by", "C2348110#ent", "<e2>", ",", "these", "transcription", "factors", "be", "crucial", "for", "the", "adaptation", "to", "hypoxia", "."], "h": {"id": "C1424440", "name": "C1424440#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C2348110", "name": "C2348110#ent", "pos": [9, 10]}}
{"token": ["The", "results", "indicate", "that", "the", "eukaryotic", "tRNA", "enzyme", ",", "C1428265#ent", "<e1>", ",", "is", "a", "downstream", "target", "of", "C0212694#ent", "<e2>"], "h": {"id": "C1428265", "name": "C1428265#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0212694", "name": "C0212694#ent", "pos": [17, 18]}}
{"token": ["We", "analyzed", "the", "effects", "of", "]", "inhibitors", ",", "dofetilide", "and", "C0082359#ent", "<e1>", ",", "and", "a", "class", "I", "antiarrhythmic", "agent", "C0012702#ent", "<e2>", ",", "on", "electrical", "cardiac", "responses", "to", "vagus", "stimulation", "anesthetized", "dogs", "."], "h": {"id": "C0082359", "name": "C0082359#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0012702", "name": "C0012702#ent", "pos": [19, 20]}}
{"token": ["There", "was", ",", "however", ",", "a", "marked", "improvement", "of", "the", "brush", "border", "abnormalities", "characteristic", "of", "C0007570#ent", "<e1>", "during", "culture", "with", "increased", "C0014442#ent", "<e2>", "activities", "and", "membrane", "equilibrium", "density", "the", "sucrose", "gradients"], "h": {"id": "C0007570", "name": "C0007570#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [21, 22]}}
{"token": ["C1419210#ent", "<e1>", "DeltaCT", "was", "then", "shown", "to", "prevent", "C2982484#ent", "<e2>", "translocation", "induced", "by", "the", "expression", "of", "an", "active", "form", "phosphatidylinositol", "3-kinase", "of", "protein", "kinase", "B", "without", "altering", "the", "activities", "of", "the", "enzymes", "."], "h": {"id": "C1419210", "name": "C1419210#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2982484", "name": "C2982484#ent", "pos": [8, 9]}}
{"token": ["These", "results", "suggest", "that", "lower", "nitric", "oxide", "production", "in", "the", "brain", "may", "be", "related", "to", "the", "susceptibility", "of", "the", "C3811848#ent", "<e1>", "mouse", "to", "C0751494#ent", "<e2>"], "h": {"id": "C3811848", "name": "C3811848#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0751494", "name": "C0751494#ent", "pos": [23, 24]}}
{"token": ["In", "this", "context", ",", "naturally", "emerging", "C0029896#ent", "<e1>", "such", "as", "SARS", ",", "C0276180#ent", "<e2>", "or", "West", "Nile", "fever", "new", "importance", "because", "it", "is", "difficult", "to", "distinguish", "between", "natural", "epidemics", "possible", "bioweapon", "assaults", "."], "h": {"id": "C0029896", "name": "C0029896#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0276180", "name": "C0276180#ent", "pos": [12, 13]}}
{"token": ["In", "a", "closed", "system", "mitochondrial", "respiration", "in", "decreased", "oxygen", "partial", "pressure", "pO(2", ")", ")", "and", "enhanced", "conversion", "of", "C0069830#ent", "<e1>", "(", "OxyMb", ")", "to", "C0057444#ent", "<e2>", "(", "DeoMb", ")", "or", "metmyoglobin", "(", "MetMb", ")", "."], "h": {"id": "C0069830", "name": "C0069830#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0057444", "name": "C0057444#ent", "pos": [24, 25]}}
{"token": ["Deoxymyoglobin", "reactivity", "was", "similar", "to", "that", "of", "met-myoglobin", ",", "but", "the", "reactivity", "of", "C0069830#ent", "<e1>", "was", "retarded", "compared", "to", "C0057444#ent", "<e2>", "."], "h": {"id": "C0069830", "name": "C0069830#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0057444", "name": "C0057444#ent", "pos": [19, 20]}}
{"token": ["The", "results", "suggest", "that", "there", "was", "no", "interaction", "between", "C0053105#ent", "<e1>", "and", "the", "C0003280#ent", "<e2>"], "h": {"id": "C0053105", "name": "C0053105#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0003280", "name": "C0003280#ent", "pos": [13, 14]}}
{"token": ["The", "major", "C0017835#ent", "<e1>", "GST", ")", "isoenzyme", "in", "human", "C0023524#ent", "<e2>", "is", "GST", "P1", "-", "1", ",", "a", "Pi-class", "form", "."], "h": {"id": "C0017835", "name": "C0017835#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0023524", "name": "C0023524#ent", "pos": [9, 10]}}
{"token": ["Incubation", "of", "C0008928#ent", "<e1>", "with", "lipopolysaccharide", "(", "C0175697#ent", "<e2>", ")", "and", "interferon-gamma", ",", "which", "induces", "NOS", "in", "macrophages", ",", "decreased", "H(+)-ATPase", "activity", "85", "%", "."], "h": {"id": "C0008928", "name": "C0008928#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [7, 8]}}
{"token": ["The", "gene", "appears", "to", "be", "the", "murine", "ortholog", "of", "the", "C1537647#ent", "<e1>", "that", "is", ",", "C1537647#ent", "<e1>", "."], "h": {"id": "C1537647", "name": "C1537647#ent", "pos": [10, 11]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1537647", "name": "C1537647#ent", "pos": [10, 11]}}
{"token": ["To", "compare", "the", "effect", "of", "an", "intravitreal", "injection", "of", "bevacizumab", ",", "an", "anti-vascular", "endothelial", "growth", "factor", "C2349086#ent", "<e1>", ")", "antibody", ",", "with", "that", "of", "C0040866#ent", "<e2>", "a", "corticosteroid", "for", "reduction", "of", "diabetic", "macular", "edema", "DME", ")", "."], "h": {"id": "C2349086", "name": "C2349086#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0040866", "name": "C0040866#ent", "pos": [24, 25]}}
{"token": ["In", "the", "second", "part", "of", "this", "experiment", ",", "single", "or", "combined", "effects", "of", "VCR", "and", "immunotherapeutic", "agents", "C0918027#ent", "<e1>", "(", "OK", ")", ",", "PSK", ",", "and", "C0751599#ent", "<e2>", "IFN", ")", "were", "examined", "."], "h": {"id": "C0918027", "name": "C0918027#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0751599", "name": "C0751599#ent", "pos": [26, 27]}}
{"token": ["Included", "in", "these", "will", "be", "the", "oxidative", "damage", "that", "occurs", "to", "these", "membranes", "and", "the", "dissociation", "of", "lipids", "and", "C0086376#ent", "<e1>", "that", "accompanies", "the", "C0003429#ent", "<e2>", "process", "."], "h": {"id": "C0086376", "name": "C0086376#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0003429", "name": "C0003429#ent", "pos": [24, 25]}}
{"token": ["The", "C0039082#ent", "<e1>", "is", "caused", "by", "mutations", "in", "the", "C1427193#ent", "<e2>", "gene", ",", "which", "maps", "to", "Xp11.4", "."], "h": {"id": "C0039082", "name": "C0039082#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1427193", "name": "C1427193#ent", "pos": [9, 10]}}
{"token": ["A", "positive", "relationship", "between", "enhanced", "interaction", "of", "C1415764#ent", "<e1>", "with", "either", "C1565830#ent", "<e2>", "or", "nitric", "oxide", "synthase", "mucosal", "protection", "against", "a", "strong", "irritant", "(", "100", "%", "ethanol", ")", "was", "observed", "."], "h": {"id": "C1415764", "name": "C1415764#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1565830", "name": "C1565830#ent", "pos": [11, 12]}}
{"token": ["In", "human", "fetal", "C0669372#ent", "<e1>", ",", "this", "aberrant", "induction", "of", "SOX9", "protein", "ectopic", "expression", "of", "C1852996#ent", "<e2>", "and", "COMP1", "that", "encode", "extracellular", "matrix", "ECM", ")", "components", "normally", "associated", "with", "chondrogenesis", "."], "h": {"id": "C0669372", "name": "C0669372#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1852996", "name": "C1852996#ent", "pos": [15, 16]}}
{"token": ["All", "C1564139#ent", "<e1>", "a", "decrease", "in", "accessibility", "to", "acrylamide", "once", "C0059037#ent", "<e2>", "bound", ",", "although", "the", "relative", "change", "varied", "for", "each", "labelled", "protein", "."], "h": {"id": "C1564139", "name": "C1564139#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0059037", "name": "C0059037#ent", "pos": [10, 11]}}
{"token": ["Uptake", "of", "C0025598#ent", "<e1>", "was", "facilitated", "by", "over-expression", "of", "hOCT1", "and", "C1335234#ent", "<e2>", "and", "showed", "saturable", "processes", ",", "indicating", "that", "C0025598#ent", "<e1>", "is", "a", "substrate", "of", "hOCT1", "and", "C1335234#ent", "<e2>", "."], "h": {"id": "C0025598", "name": "C0025598#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335234", "name": "C1335234#ent", "pos": [11, 12]}}
{"token": ["Malignant", "hyperthermia", "(", "MH", ")", "is", "a", "pharmacogenetic", "disease", "predisposes", "to", "the", "trigger", "of", "a", "life-threatening", ",", "hypermetabolic", "syndrome", "potent", "C0002932#ent", "<e1>", "by", "depolarizing", "skeletal", "muscle", "C0042402#ent", "<e2>", "."], "h": {"id": "C0002932", "name": "C0002932#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0042402", "name": "C0042402#ent", "pos": [26, 27]}}
{"token": ["Microsomal", "preparations", "from", "150", "mg/kg", "beta", "NF-pretreated", "mice", "showed", "a", "3-fold", "induction", "of", "C0919425#ent", "<e1>", "activity", "and", "a", "6.8-fold", "induction", "of", "AFB1", "-", "C0033384#ent", "<e2>", "activity", "."], "h": {"id": "C0919425", "name": "C0919425#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0033384", "name": "C0033384#ent", "pos": [23, 24]}}
{"token": ["The", "authors", "report", "an", "unusual", "case", "of", "bilateral", "short", "term", "C0029191#ent", "<e1>", "a", "patient", "with", "recurrent", "C0031069#ent", "<e2>", "(", "familial", "Mediterranean", "fever", "."], "h": {"id": "C0029191", "name": "C0029191#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0031069", "name": "C0031069#ent", "pos": [16, 17]}}
{"token": ["The", "influence", "of", "C0043167#ent", "<e1>", "and", "cholera", "toxin-sensitive", "G-proteins", "in", "the", "C0033568#ent", "<e2>", "been", "investigated", "."], "h": {"id": "C0043167", "name": "C0043167#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0033568", "name": "C0033568#ent", "pos": [11, 12]}}
{"token": ["Using", "the", "yeast", "two-hybrid", "screening", "system", "we", "found", "that", "the", "oxygen", "dependent", "degradation", "(", "C1415068#ent", "<e1>", ")", "domain", "of", "HIF-1alpha", "interacts", "with", "C1417614#ent", "<e2>", ",", "a", "growth", "suppressor"], "h": {"id": "C1415068", "name": "C1415068#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1417614", "name": "C1417614#ent", "pos": [22, 23]}}
{"token": ["In", "patients", "with", "C0263338#ent", "<e1>", "delayed", "reactions", "PAF", "and", "C0752224#ent", "<e2>", "were", "larger", "than", "in", "healthy", "subjects"], "h": {"id": "C0263338", "name": "C0263338#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0752224", "name": "C0752224#ent", "pos": [9, 10]}}
{"token": ["Our", "aim", "here", "was", "to", "study", "the", "postoperative", "outcomes", "of", "C0149516#ent", "<e1>", "complicated", "by", "bronchial", "asthma", "of", "cases", "with", "eosinophilic", "C0037199#ent", "<e2>"], "h": {"id": "C0149516", "name": "C0149516#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0037199", "name": "C0037199#ent", "pos": [20, 21]}}
{"token": ["The", "authors", "were", "unable", "to", "show", "that", "healthy", "elderly", "patients", "differ", "significantly", "from", "younger", "patients", "in", "the", "neuromuscular", "blocking", "of", "C0242531#ent", "<e1>", "and", "the", "reversal", "effect", "C0013617#ent", "<e2>", "."], "h": {"id": "C0242531", "name": "C0242531#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0013617", "name": "C0013617#ent", "pos": [26, 27]}}
{"token": ["C0004135#ent", "<e1>", ",", "SatD", ",", "and", "C2744672#ent", "<e2>", "have", "no", "homology", "to", "proteins", "with", "known", "functions", ",", "although", "YlxM", "may", "function", "as", "a", "transcriptional", "regulator", "to", "genes", "encoding", "SRP", "pathway", "proteins", "."], "h": {"id": "C0004135", "name": "C0004135#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C2744672", "name": "C2744672#ent", "pos": [6, 7]}}
{"token": ["Chlamydia", "organisms", "found", "in", "42", "per", "cent", "of", "patients", "with", "C1112709#ent", "<e1>", "these", "organisms", "probably", "were", "the", "cause", "of", "the", "C0041976#ent", "<e2>", "."], "h": {"id": "C1112709", "name": "C1112709#ent", "pos": [10, 11]}, "relation": "has_nichd_parent", "t": {"id": "C0041976", "name": "C0041976#ent", "pos": [20, 21]}}
{"token": ["58", "patients", "with", "severe", "C0020538#ent", "<e1>", "AH", ")", "refractory", "to", "antihypertensive", "drug", "therapy", "beta-blockers", ",", "calcium", "antagonists", "C0242889#ent", "<e2>", "diuretics", "with", "addition", "of", "captopril", "and/or", "minoxidil", "were", "studied", "."], "h": {"id": "C0020538", "name": "C0020538#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0242889", "name": "C0242889#ent", "pos": [17, 18]}}
{"token": ["Angiotensin", "II", "C1424250#ent", "<e1>", ")", ",", "aldosterone", "(", "Aldo", ")", "and", "arginine", "vasopressin", "C1706109#ent", "<e2>", ")", "in", "plasma", "were", "determined", "during", "basal", "conditions", "in", "seventeen", "patients", "with", "congestive", "heart", "failure", "in", "seventeen", "control", "subjects"], "h": {"id": "C1424250", "name": "C1424250#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1706109", "name": "C1706109#ent", "pos": [13, 14]}}
{"token": ["Hematopoietic", "stem", "cell", "HSC", ")", "development", "is", "regulated", "by", "several", "signaling", "pathways", "a", "number", "of", "key", "transcription", "factors", "which", "include", "C1420065#ent", "<e1>", ",", "Runx1", ",", "and", "members", "of", "the", "C1334468#ent", "<e2>"], "h": {"id": "C1420065", "name": "C1420065#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1334468", "name": "C1334468#ent", "pos": [29, 30]}}
{"token": ["This", "case", "was", "considered", "as", "one", "of", "the", "imported", "C0747256#ent", "<e1>", "Korea", ",", "and", "a", "rare", "case", "of", "C0019911#ent", "<e2>", "human", "rectal", "mucosa"], "h": {"id": "C0747256", "name": "C0747256#ent", "pos": [9, 10]}, "relation": "nichd_parent_of", "t": {"id": "C0019911", "name": "C0019911#ent", "pos": [18, 19]}}
{"token": ["When", "C3179011#ent", "<e1>", "traits", "are", "heritable", ",", "interspecific", "C1840252#ent", "<e2>", "cause", "species", "interactions", "to", "change", ",", "and", "community", "evolution", "occurs", "."], "h": {"id": "C3179011", "name": "C3179011#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1840252", "name": "C1840252#ent", "pos": [8, 9]}}
{"token": ["C0033806#ent", "<e1>", ":", "Often", "in", "families", "with", "type", "Ia", "pseudohypoparathyroidism", "subjects", "with", "C3494506#ent", "<e2>", ",", "with", "no", "features", "of", "PTH", "resistance", ",", "are", "said", "to", "have", "pseudopseudohypoparathyroidism", "."], "h": {"id": "C0033806", "name": "C0033806#ent", "pos": [0, 1]}, "relation": "manifestation_of", "t": {"id": "C3494506", "name": "C3494506#ent", "pos": [12, 13]}}
{"token": ["We", "examined", "whether", "stabilized", "C1705526#ent", "<e1>", "is", "functional", "in", "C1422512#ent", "<e2>", "transgenic", "mice"], "h": {"id": "C1705526", "name": "C1705526#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1422512", "name": "C1422512#ent", "pos": [9, 10]}}
{"token": ["CD14-HLA-DRhigh/DC", "expressed", "higher", "levels", "of", "C2985420#ent", "<e1>", "lower", "levels", "of", "C1413188#ent", "<e2>", "and", "CCR5", ",", "but", "all", "cell", "populations", "similar", "CCR7", "levels", "."], "h": {"id": "C2985420", "name": "C2985420#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1413188", "name": "C1413188#ent", "pos": [10, 11]}}
{"token": ["Guinea", "pig", "antiserum", "against", "C0608437#ent", "<e1>", "inhibited", "the", "omega-hydroxylation", "of", "C3714974#ent", "<e2>", "by", "kidney", "cortex", "microsomes", "from", "clofibrate-treated", "rabbits", "."], "h": {"id": "C0608437", "name": "C0608437#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3714974", "name": "C3714974#ent", "pos": [10, 11]}}
{"token": ["The", "most", "frequent", "partner", "genes", "BCR", ",", "C1824717#ent", "<e1>", ",", "FOP", ",", "and", "C1823958#ent", "<e2>", ",", "localized", "on", "22q11", ",", "9q33", ",", "6q27", ",", "and", "13q12", ",", "respectively", "."], "h": {"id": "C1824717", "name": "C1824717#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1823958", "name": "C1823958#ent", "pos": [13, 14]}}
{"token": ["Monoclonal", "anti-human", "erythropoietin", "antibody", "C1333342#ent", "<e1>", "abrogated", "the", "erythroid", "differentiative", "ability", "of", "C0812443#ent", "<e2>", "in", "the", "serum-containing", "systems", "."], "h": {"id": "C1333342", "name": "C1333342#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0812443", "name": "C0812443#ent", "pos": [12, 13]}}
{"token": ["C1839163#ent", "<e1>", "was", "incorporated", "in", "C0032483#ent", "<e2>", "hydroxypropylcellulose", "matrices", "a", "hot-melt", "fabrication", "procedure", ",", "utilizing", "various", "processing", "aids", "."], "h": {"id": "C1839163", "name": "C1839163#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0032483", "name": "C0032483#ent", "pos": [5, 6]}}
{"token": ["Our", "study", "thus", "reveals", "novel", "and", "nonredundant", "functions", "for", "C1422120#ent", "<e1>", ":", "It", "acts", "as", "a", "coactivator", "for", "C1417102#ent", "<e2>", "transcription", "and", "is", "essential", "for", "proper", "muscle", "development"], "h": {"id": "C1422120", "name": "C1422120#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1417102", "name": "C1417102#ent", "pos": [18, 19]}}
{"token": ["At", "four", "subsequent", "randomized", "visits", "subjects", "received", "this", "concentration", "of", "PGD2", "90", "min", "after", "dosing", "with", "placebo", "or", "20", ",", "50", "or", "100", "mg", "of", "C0378481#ent", "<e1>", "a", "potent", "competitive", "C0019593#ent", "<e2>"], "h": {"id": "C0378481", "name": "C0378481#ent", "pos": [25, 26]}, "relation": "NA", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [30, 31]}}
{"token": ["C3539185#ent", "<e1>", "(", "Cs", ")", "are", "widely", "used", "for", "treatment", "of", "C1417325#ent", "<e2>", "MS", ")", "acute", "relapses", "because", "of", "the", "potent", "immunosuppressive", "and", "anti-inflammatory", "properties"], "h": {"id": "C3539185", "name": "C3539185#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417325", "name": "C1417325#ent", "pos": [11, 12]}}
{"token": ["C1452313#ent", "<e1>", "1", ",", "DTM", "2", ",", "5-FU", "3", ",", "and", "C3887938#ent", "<e2>", "4", "were", "tested", "for", "their", "cytotoxic", "effects", "NIH", "3T3", "fibroblasts", "using", "two", "different", "assays", ",", "the", "MTT", "assay", "SRB", "assay", "."], "h": {"id": "C1452313", "name": "C1452313#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3887938", "name": "C3887938#ent", "pos": [11, 12]}}
{"token": ["C1418625#ent", "<e1>", "PAF-AH", ")", "is", "a", "C2351517#ent", "<e2>", "of", "hydrolyzing", "platelet-activating", "factor", "PAF", ")", "and", "oxidatively", "modified", "phospholipids", "."], "h": {"id": "C1418625", "name": "C1418625#ent", "pos": [0, 1]}, "relation": "gene_encodes_gene_product", "t": {"id": "C2351517", "name": "C2351517#ent", "pos": [6, 7]}}
{"token": ["Patients", "with", "head", "and", "neck", "C1824729#ent", "<e1>", "received", "preoperative", "adriamycin", "and", "5-(dimethyltriazeno", ")", "C0392206#ent", "<e2>", "or", "a", "combination", "of", "vincristine", ",", "actinomycin", "D", "and", "cyclophosphamide", "."], "h": {"id": "C1824729", "name": "C1824729#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0392206", "name": "C0392206#ent", "pos": [13, 14]}}
{"token": ["Mouse", "R-spondin2", "(", "Rspo2", ")", "is", "a", "member", "of", "the", "C1704989#ent", "<e1>", "which", "is", "characterized", "by", "furin-like", "cysteine-rich", "domains", "a", "C1336626#ent", "<e2>"], "h": {"id": "C1704989", "name": "C1704989#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1336626", "name": "C1336626#ent", "pos": [20, 21]}}
{"token": ["These", "C0012634#ent", "<e1>", "include", "desquamative", "interstitial", "pneumonia", "DIP", ")", ",", "C0238378#ent", "<e2>", "RB-ILD", ")", ",", "pulmonary", "Langerhans", "'", "cell", "histiocytosis", "LCH", ")", "and", "idiopathic", "pulmonary", "fibrosis", "IPF", ")", "."], "h": {"id": "C0012634", "name": "C0012634#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0238378", "name": "C0238378#ent", "pos": [10, 11]}}
{"token": ["C2939462#ent", "<e1>", "the", "cancer", ",", "multiple", "myeloma", "are", "characterized", "by", "the", "C0001622#ent", "<e2>", "of", "free", "antibody", "light", "chains"], "h": {"id": "C2939462", "name": "C2939462#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001622", "name": "C0001622#ent", "pos": [11, 12]}}
{"token": ["Plasma", "exchange", "also", "been", "used", "to", "remove", "other", "circulating", "nephrotoxic", "agents", "as", "antiglomerular", "basement", "antibodies", "that", "cause", "Goodpasture's", "syndrome", "protease", "inhibitor", "autoantibodies", "cause", "C0034155#ent", "<e1>", "and", "antiglomerular", "factors", "that", "cause", "some", "types", "of", "C0178664#ent", "<e2>"], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0178664", "name": "C0178664#ent", "pos": [33, 34]}}
{"token": ["A", "combination", "of", "C0034282#ent", "<e1>", "and", "metiamide", "abolished", "responses", "to", "all", "C0521879#ent", "<e2>"], "h": {"id": "C0034282", "name": "C0034282#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0521879", "name": "C0521879#ent", "pos": [11, 12]}}
{"token": ["In", "addition", ",", "we", "observed", ",", "for", "the", "first", "time", ",", "that", "upregulation", "of", "sterol", "response", "element-binding", "protein", "SREBP", ")", ",", "known", "to", "induce", "C1335238#ent", "<e1>", "expression", ",", "can", "increase", "C0694888#ent", "<e2>", "expression", "."], "h": {"id": "C1335238", "name": "C1335238#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0694888", "name": "C0694888#ent", "pos": [30, 31]}}
{"token": ["In", "45", "cases", "of", "trisomy", "18", "and", "493", "control", "pregnancies", "10", "-", "14", "weeks", "of", "gestation", ",", "maternal", "C1527057#ent", "<e1>", "total", "activin", "A", ",", "free", "beta-hCG", "and", "C2984583#ent", "<e2>", "were", "measured", "."], "h": {"id": "C1527057", "name": "C1527057#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C2984583", "name": "C2984583#ent", "pos": [27, 28]}}
{"token": ["Three", "C0290178#ent", "<e1>", "been", "identified", "in", "vertebrates", ":", "C1335227#ent", "<e2>", ",", "Plk2", "and", "Plk3", "."], "h": {"id": "C0290178", "name": "C0290178#ent", "pos": [1, 2]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1335227", "name": "C1335227#ent", "pos": [8, 9]}}
{"token": ["C0002963#ent", "<e1>", "complications", "have", "recently", "been", "reported", "after", "C0062512#ent", "<e2>", "."], "h": {"id": "C0002963", "name": "C0002963#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0062512", "name": "C0062512#ent", "pos": [8, 9]}}
{"token": ["PTPase", "activities", "were", "assayed", "by", "measuring", "the", "dephosphorylation", "of", "a", "rat", "insulin", "receptor", "kinase", "domain", "derivatized", "lysozyme", "C0028189#ent", "<e1>", ",", "and", "the", "C3541394#ent", "<e2>", "were", "further", "characterized", "by", "immunoblotting", "."], "h": {"id": "C0028189", "name": "C0028189#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C3541394", "name": "C3541394#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "69", "%", "had", "C0270860#ent", "<e1>", "BM", ")", "symptoms", "during", "C1832884#ent", "<e2>", "attacks", "."], "h": {"id": "C0270860", "name": "C0270860#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1832884", "name": "C1832884#ent", "pos": [12, 13]}}
{"token": ["They", "include", "vulvodynia", ",", "C0036396#ent", "<e1>", ",", "urethral", "syndrome", "penile", "pain", "prostatodynia", ",", "coccygodynia", ",", "perineal", "pain", "C0240812#ent", "<e2>", "and", "proctalgia", "fugax"], "h": {"id": "C0036396", "name": "C0036396#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0240812", "name": "C0240812#ent", "pos": [17, 18]}}
{"token": ["Administration", "of", "tyramine", "(", "with", "or", "without", "C0733398#ent", "<e1>", ")", "as", "well", "as", "induction", "of", "ether", "anesthesia", "C0858734#ent", "<e2>", "a", "sharp", "increase", "in", "plasma", "cyclic", "AMP", "in", "rats", "."], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0858734", "name": "C0858734#ent", "pos": [17, 18]}}
{"token": ["C1538440#ent", "<e1>", "in", "p53", "mutants", "are", "characterized", "by", "down-regulation", "of", "C0015923#ent", "<e2>", "and", "insulin-like", "growth", "factor-binding", "protein", "3", "by", "increased", "expression", "of", "Bcl-2", "."], "h": {"id": "C1538440", "name": "C1538440#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0015923", "name": "C0015923#ent", "pos": [10, 11]}}
{"token": ["This", "biochemical", "property", "is", "C1516876#ent", "<e1>", "determined", "and", "concerns", "the", "C0684287#ent", "<e2>", "the", "hepatic", "cytosol"], "h": {"id": "C1516876", "name": "C1516876#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0684287", "name": "C0684287#ent", "pos": [10, 11]}}
{"token": ["Numerous", "thin", "periportal", "VP", "and", "C0225326#ent", "<e1>", "in", "the", "normal", "and", "C1706171#ent", "<e2>", "rats", ";", "they", "have", "never", "been", "observed", "in", "the", "DI", "rats", "."], "h": {"id": "C0225326", "name": "C0225326#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1706171", "name": "C1706171#ent", "pos": [11, 12]}}
{"token": ["Our", "results", "further", "demonstrate", "the", "regulation", "of", "C3889152#ent", "<e1>", "transmission", "by", "C0242893#ent", "<e2>"], "h": {"id": "C3889152", "name": "C3889152#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0242893", "name": "C0242893#ent", "pos": [11, 12]}}
{"token": ["The", "correlation", "between", "C0008746#ent", "<e1>", "and", "the", "other", "C3540790#ent", "<e2>", "was", "markedly", "modulated", "by", "MK-329", "."], "h": {"id": "C0008746", "name": "C0008746#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3540790", "name": "C3540790#ent", "pos": [8, 9]}}
{"token": ["Adverse", "drug", "reactions", "observed", "were", "C0012242#ent", "<e1>", "anorexia", "and", "C0027498#ent", "<e2>", ")", "and", "malaise", "."], "h": {"id": "C0012242", "name": "C0012242#ent", "pos": [5, 6]}, "relation": "related_to", "t": {"id": "C0027498", "name": "C0027498#ent", "pos": [9, 10]}}
{"token": ["The", "C0027203#ent", "<e1>", "responsible", "for", "the", "4-hydroxylation", "of", "C0054655#ent", "<e2>", "in", "vitro", "shown", "by", "the", "use", "of", "inhibitors", "to", "be", "liver", "aldehyde", "oxidase"], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0054655", "name": "C0054655#ent", "pos": [8, 9]}}
{"token": ["In", "the", "yeast", "system", "C1419392#ent", "<e1>", "interacts", "with", "Rap", "1A", "C1705572#ent", "<e2>", "and", "R-Ras", ",", "but", "not", "with", "Rac", "and", "Rho", "."], "h": {"id": "C1419392", "name": "C1419392#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705572", "name": "C1705572#ent", "pos": [10, 11]}}
{"token": ["Visual", "outcome", "was", "analysed", "in", "16", "consecutive", "C0235267#ent", "<e1>", "with", "symptomatic", "C4024755#ent", "<e2>", "treated", "by", "direct", "laser", "photocoagulation", "26", "consecutive", "symptomatic", "C0235267#ent", "<e1>", "followed", "with", "no", "treatment"], "h": {"id": "C0235267", "name": "C0235267#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4024755", "name": "C4024755#ent", "pos": [11, 12]}}
{"token": ["An", "increase", "in", "interstitial", "adenosine", "preconditioning", "is", "thought", "to", "be", "derived", "primarily", "from", "hydrolysis", "of", "5'-AMP", "in", "the", "myocyte", "by", "C1425101#ent", "<e1>", "although", "a", "contribution", "of", "C1701467#ent", "<e2>", "controversial", "."], "h": {"id": "C1425101", "name": "C1425101#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C1701467", "name": "C1701467#ent", "pos": [26, 27]}}
{"token": ["The", "symptoms", "(", "C0010200#ent", "<e1>", ",", "fever", ",", "and", "C0038450#ent", "<e2>", ")", "resolved", "and", "the", "small", "nodules", "chest", "CT", "scan", ",", "but", "hypoxemia", "remained", "."], "h": {"id": "C0010200", "name": "C0010200#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0038450", "name": "C0038450#ent", "pos": [9, 10]}}
{"token": ["By", "inference", ",", "hypercortisolism", "in", "hospitalized", "patients", "with", "severe", "depression", "or", "in", "C0010340#ent", "<e1>", "induce", "down-regulation", "of", "the", "C1442521#ent", "<e2>", "axis", "at", "the", "level", "of", "the", "hypothalamus", "."], "h": {"id": "C0010340", "name": "C0010340#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1442521", "name": "C1442521#ent", "pos": [18, 19]}}
{"token": ["This", "study", "aims", "to", "investigate", "the", "difference", "of", "ECCA", "C0003850#ent", "<e1>", "between", "patients", "with", "C0302314#ent", "<e2>", "and", "control", "subjects", "normolipidaemia", "."], "h": {"id": "C0003850", "name": "C0003850#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0302314", "name": "C0302314#ent", "pos": [14, 15]}}
{"token": ["L-NIL-TA", "is", "C0025517#ent", "<e1>", "via", "a", "single", "hydrolysis", "pathway", "to", "form", "the", "active", "drug", "C0291371#ent", "<e2>", "(", "L-NIL", ")", "."], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0291371", "name": "C0291371#ent", "pos": [14, 15]}}
{"token": ["Purified", ",", "reconstituted", "human", "C0534137#ent", "<e1>", "also", "inactivated", "by", "C1420488#ent", "<e2>", "with", "a", "KI", "of", "12", "microM.", "The", "kinactivation", "for", "C0534137#ent", "<e1>", "0.06", "min-1", ",", "and", "the", "t1/2", "was", "11", "min", "."], "h": {"id": "C1420488", "name": "C1420488#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0534137", "name": "C0534137#ent", "pos": [4, 5]}}
{"token": ["Furthermore", ",", "expression", "of", "dominant-negative", "C3538776#ent", "<e1>", "(", "LSFdn", ")", "prevents", "the", "increase", "in", "TS", "C0014442#ent", "<e2>", "levels", "during", "G(1)-S", ",", "and", "induces", "apoptosis", "in", "growth-", "stimulated", "mouse", "and", "human", "cell", "lines"], "h": {"id": "C3538776", "name": "C3538776#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0014442", "name": "C0014442#ent", "pos": [15, 16]}}
{"token": ["In", "BAT", "of", "C1883559#ent", "<e1>", "(-)-norepinephrine", "maximally", "stimulated", "C1706390#ent", "<e2>", "4.1+/-0.8", "fold", "."], "h": {"id": "C1883559", "name": "C1883559#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1706390", "name": "C1706390#ent", "pos": [8, 9]}}
{"token": ["Acute", "promyelocytic", "leukemia", "caused", "by", "chromosomal", "translocations", "which", "in", "the", "large", "majority", "of", "cases", "generate", "the", "prototypic", "promyelocytic", "leukemia-retinoic-acid", "receptor", "alpha", "(", "C1709412#ent", "<e1>", ")", "an", "oncogenic", "fusion", "protein", "from", "the", "C1366536#ent", "<e2>", "the", "so-called", "PML", "protein"], "h": {"id": "C1709412", "name": "C1709412#ent", "pos": [22, 23]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [31, 32]}}
{"token": ["Corneal", "opacities", "C0149745#ent", "<e1>", ",", "circumscribed", "palmoplantar", "keratoderma", "subnormal", "intelligence", "form", "the", "classical", "triad", "this", "C0039082#ent", "<e2>", "."], "h": {"id": "C0149745", "name": "C0149745#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0039082", "name": "C0039082#ent", "pos": [15, 16]}}
{"token": ["In", "some", "patients", "C0010347#ent", "<e1>", "was", "successfully", "replaced", "by", "C0022642#ent", "<e2>", "."], "h": {"id": "C0010347", "name": "C0010347#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022642", "name": "C0022642#ent", "pos": [9, 10]}}
{"token": ["Co-immunoprecipitation", "experiments", "demonstrated", "that", "C0518948#ent", "<e1>", "the", "interaction", "of", "Rac", "with", "C1421480#ent", "<e2>", "and", "Abi-1", ",", "but", "not", "with", "IRSp53", "."], "h": {"id": "C0518948", "name": "C0518948#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1421480", "name": "C1421480#ent", "pos": [11, 12]}}
{"token": ["To", "discriminate", "between", "antineoplastic", "effects", "NSAIDs", "that", "are", "mediated", "by", "either", "C1412324#ent", "<e1>", "or", "cyclooxygenase", "(", "COX", ")", "C0026794#ent", "<e2>", ",", "selective", "inhibitors", "required", "."], "h": {"id": "C1412324", "name": "C1412324#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0026794", "name": "C0026794#ent", "pos": [18, 19]}}
{"token": ["C0207509#ent", "<e1>", "is", "not", "detected", "by", "sera", "of", "patients", "with", "isolated", "C0400936#ent", "<e2>", "might", "be", "a", "hepatic", "marker", "autoantigen", "patients", "with", "APS1", "."], "h": {"id": "C0207509", "name": "C0207509#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0400936", "name": "C0400936#ent", "pos": [11, 12]}}
{"token": ["Since", "membrane", "fluidity", "closely", "involved", "in", "various", "cell", "membrane", "functions", "the", "decreased", "membrane", "fluidity", "altered", "lipid", "composition", "C1420193#ent", "<e1>", "in", "patients", "with", "C0156147#ent", "<e2>", "have", "important", "effects", "on", "the", "pathological", "status", "this", "disease", "."], "h": {"id": "C1420193", "name": "C1420193#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C0156147", "name": "C0156147#ent", "pos": [22, 23]}}
{"token": ["These", "observations", "suggest", "that", "the", "C0022658#ent", "<e1>", "Arima", "syndrome", "in", "accordance", "with", "C0687120#ent", "<e2>", "both", "clinically", "and", "pathologically", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0687120", "name": "C0687120#ent", "pos": [12, 13]}}
{"token": ["We", "performed", "an", "open-label", "study", "C0002395#ent", "<e1>", "patients", "on", "the", "use", "of", "C0772415#ent", "<e2>", "in", "clinical", "routine"], "h": {"id": "C0002395", "name": "C0002395#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0772415", "name": "C0772415#ent", "pos": [12, 13]}}
{"token": ["WT", "mice", "showed", "increased", "levels", "of", "the", "endoplasmic", "reticulum", "stress", "pathway", "proteins", "phosphorylated", "eukaryotic", "translation", "initiation", "factor", "alpha", "phosphorylated", "pancreatic", "endoplasmic", "reticulum", "kinase", "and", "C1413947#ent", "<e1>", "along", "with", "inflammatory", "markers", "nuclear", "factor", "kappaB", "and", "phosphorylated", "C1623430#ent", "<e2>", "N-terminal", "kinase", "to", "chow-fed", "controls", "."], "h": {"id": "C1413947", "name": "C1413947#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C1623430", "name": "C1623430#ent", "pos": [35, 36]}}
{"token": ["The", "possible", "effects", "of", "C3541396#ent", "<e1>", "in", "the", "modulation", "of", "the", "activity", "of", "glycolytic", "enzymes", "phosphofructokinase", "C0034348#ent", "<e2>", "tyrosine", "kinase-mediated", "signal", "transduction", "isolated", "digestive", "gland", "cells", "from", "mussels", "(", "Mytilus", "galloprovincialis", "Lam", ".", ")"], "h": {"id": "C3541396", "name": "C3541396#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034348", "name": "C0034348#ent", "pos": [16, 17]}}
{"token": ["C0729570#ent", "<e1>", "(", "PRTase", ")", "and", "C0133234#ent", "<e2>", "NPase", ")", "activities", "were", "detected", "by", "radiometric", "methods", "extracts", "of", "Methanococcus", "voltae"], "h": {"id": "C0729570", "name": "C0729570#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0133234", "name": "C0133234#ent", "pos": [6, 7]}}
{"token": ["It", "is", "suggested", "that", "increased", "ANA", "and", "anti-DNA", "antibodies", "C0263664#ent", "<e1>", "associated", "with", "joint", "manifestations", "represents", "a", "systemic", "component", "this", "C0011644#ent", "<e2>", "with", "activation", "of", "the", "immune", "system", "similarities", "with", "generalized", "collagen", "diseases"], "h": {"id": "C0263664", "name": "C0263664#ent", "pos": [9, 10]}, "relation": "has_nichd_parent", "t": {"id": "C0011644", "name": "C0011644#ent", "pos": [20, 21]}}
{"token": ["Two", "forms", "(", "C1413109#ent", "<e1>", "and", "CANP2", ")", "of", "a", "C1436406#ent", "<e2>", "CANP", ")", "have", "been", "purified", ",", "1,950-", "and", "1,250-fold", ",", "respectively", ",", "to", "near", "homogeneity", "from", "calf", "brain", "."], "h": {"id": "C1413109", "name": "C1413109#ent", "pos": [3, 4]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1436406", "name": "C1436406#ent", "pos": [10, 11]}}
{"token": ["We", "observed", "increased", "SNO-Prx2", "in", "human", "Parkinson's", "disease", "C3160718#ent", "<e1>", ")", "brains", ",", "and", "S-nitrosylation", "of", "C1418880#ent", "<e2>", "inhibited", "both", "its", "enzymatic", "activity", "protective", "function", "oxidative", "stress"], "h": {"id": "C3160718", "name": "C3160718#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1418880", "name": "C1418880#ent", "pos": [16, 17]}}
{"token": ["Exposure", "to", "a", "sublethal", "concentration", "of", "methyl", "parathion", "C1707163#ent", "<e1>", ")", "reduced", "the", "activity", "of", "cytoplasmic", "malate", "dehydrogenase", "C4083833#ent", "<e2>", "and", "lactate", "dehydrogenase", "30", "to", "49", "%", "in", "the", "liver", "and", "the", "skeletal", "muscle", "the", "freshwater", "catfish"], "h": {"id": "C1707163", "name": "C1707163#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C4083833", "name": "C4083833#ent", "pos": [18, 19]}}
{"token": ["In", "saturation", "experiments", ",", "C0009011#ent", "<e1>", "and", "PK", "11195", "significantly", "increased", "C1839259#ent", "<e2>", "but", "not", "Bmax", "of", "the", "labelled", "ligand", "while", "Ro", "5", "4864", "increased", "both", "C1839259#ent", "<e2>", "and", "Bmax", "."], "h": {"id": "C0009011", "name": "C0009011#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1839259", "name": "C1839259#ent", "pos": [11, 12]}}
{"token": ["Concomitantly", ",", "insulin", "also", "up-regulated", "prosurvival", "mechanisms", "by", "elevating", "C1422599#ent", "<e1>", "and", "elements", "of", "the", "antiapoptotic", "pathway", "C0376515#ent", "<e2>", ",", "X-linked", "inhibitor", "apoptosis", ",", "and", "phosphorylated", "forkhead", "transcription", "factor"], "h": {"id": "C1422599", "name": "C1422599#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0376515", "name": "C0376515#ent", "pos": [17, 18]}}
{"token": ["The", "greatest", "C0001477#ent", "<e1>", "observed", "at", "pH", "7", ",", "while", "no", "activity", "observed", "between", "C1705397#ent", "<e2>", "2", "and", "5", "and", "at", "pH", "11", "."], "h": {"id": "C0001477", "name": "C0001477#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1705397", "name": "C1705397#ent", "pos": [14, 15]}}
{"token": ["Tubular", "secretion", "C0034665#ent", "<e1>", "was", "simplified", "to", "first-order", "brush-border", "and", "basolateral", "transport", "the", "C0268435#ent", "<e2>"], "h": {"id": "C0034665", "name": "C0034665#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268435", "name": "C0268435#ent", "pos": [13, 14]}}
{"token": ["Thus", ",", "C0066966#ent", "<e1>", "to", "be", "a", "Cytochrome", "P450", "1A1", "1A2", "C0022173#ent", "<e2>", "inducer", "in", "mammals", "."], "h": {"id": "C0066966", "name": "C0066966#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [11, 12]}}
{"token": ["Participants", "with", "a", "history", "of", "C0009766#ent", "<e1>", "SAC", ")", "were", "randomized", "to", "receive", "C0886658#ent", "<e2>", "60", ")", ",", "sodium", "cromoglycate", "61", ")", "or", "placebo", "(", "64", ")", "."], "h": {"id": "C0009766", "name": "C0009766#ent", "pos": [5, 6]}, "relation": "may_be_treated_by", "t": {"id": "C0886658", "name": "C0886658#ent", "pos": [13, 14]}}
{"token": ["The", "application", "of", "acetylcholine", ",", "short-chain", "fatty", "acids", "acetate", ",", "butyrate", "and", "C0133660#ent", "<e1>", ")", "and", "peptide", "hormones", "caerulein", "and", "bombesin", ")", "always", "caused", "C0033036#ent", "<e2>", "accompanied", "by", "a", "marked", "reduction", "in", "input", "resistance", "."], "h": {"id": "C0133660", "name": "C0133660#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0033036", "name": "C0033036#ent", "pos": [24, 25]}}
{"token": ["3-methylcholanthrene", "(MC)-induced", "mouse", "10", "embryonal", "ERSs", ")", "and", "24", "pleomorphic", "rhabdomyosarcomas", "C1415382#ent", "<e1>", ")", "of", "the", "dermis", "were", "examined", "immunohistochemically", "for", "nuclear", "reactivity", "C0812222#ent", "<e2>", ",", "p53", ",", "and", "proliferating", "cell", "nuclear", "antigen", "PCNA", ")", "."], "h": {"id": "C1415382", "name": "C1415382#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812222", "name": "C0812222#ent", "pos": [23, 24]}}
{"token": ["A", "simple", "heparin", "hexasaccharide", "cocrystallized", "with", "FGF-1", "and", "FGF-2", "and", "protected", "both", "against", "C1947941#ent", "<e1>", "in", "solution", "failed", "to", "exhibit", "the", "same", "properties", "with", "C1514773#ent", "<e2>", "."], "h": {"id": "C1947941", "name": "C1947941#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1514773", "name": "C1514773#ent", "pos": [24, 25]}}
{"token": ["In", "the", "presence", "of", "the", "C3537238#ent", "<e1>", "MG132", ",", "the", "amount", "of", "C1417767#ent", "<e2>", "its", "level", "of", "ubiquitination", "are", "increased", "."], "h": {"id": "C3537238", "name": "C3537238#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1417767", "name": "C1417767#ent", "pos": [12, 13]}}
{"token": ["The", "essential", "proteins", "NMD", "include", "SMG-1", ",", "a", "C0033640#ent", "<e1>", "and", "Upf", ",", "a", "substrate", "of", "SMG-1", "with", "C1413965#ent", "<e2>", "activity", "."], "h": {"id": "C0033640", "name": "C0033640#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1413965", "name": "C1413965#ent", "pos": [18, 19]}}
{"token": ["We", "conclude", "that", "G-CSF", "is", "rapidly", "raised", "in", "the", "blood", "in", "acute", "C0004623#ent", "<e1>", "not", "in", "acute", "viral", "infections", "in", "infections", "with", "C0032302#ent", "<e2>"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [12, 13]}, "relation": "nichd_parent_of", "t": {"id": "C0032302", "name": "C0032302#ent", "pos": [22, 23]}}
{"token": ["Other", "toxicities", "were", "also", "transient", ":", "grade", "2", "3", "C0034362#ent", "<e1>", "in", "5", "of", "16", "patients", ",", "C0040034#ent", "<e2>", "1", "of", "16", "patients", ",", "and", "grade", "2", "leucopenia", "3", "of", "16", "patients", "."], "h": {"id": "C0034362", "name": "C0034362#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0040034", "name": "C0040034#ent", "pos": [17, 18]}}
{"token": ["C0155127#ent", "<e1>", "a", "group", "of", "dominantly", "inherited", "C0442874#ent", "<e2>", ",", "with", "extracellular", "deposition", "of", "amyloid", "substance", "various", "tissues", "."], "h": {"id": "C0155127", "name": "C0155127#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0442874", "name": "C0442874#ent", "pos": [7, 8]}}
{"token": ["Imatinib", ",", "a", "C1268567#ent", "<e1>", "exhibits", "a", "competitive", "inhibition", "on", "the", "CYP450", "2D6", "C0022173#ent", "<e2>", "with", "a", "K(i", ")", "value", "of", "7.5", "microm", "."], "h": {"id": "C1268567", "name": "C1268567#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0022173", "name": "C0022173#ent", "pos": [13, 14]}}
{"token": ["Mice", "deficient", "in", "C1423507#ent", "<e1>", "develop", "a", "C0268119#ent", "<e2>", "a", "neurological", "phenotype", "mimics", "startle", "disease", "hyperekplexia", ")", "."], "h": {"id": "C1423507", "name": "C1423507#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268119", "name": "C0268119#ent", "pos": [7, 8]}}
{"token": ["To", "quantify", "the", "neuromuscular", "blockade", "C1415205#ent", "<e1>", ")", "produced", "by", "C0004234#ent", "<e2>", "in", "either", "sevoflurane", "or", "propofol-anaesthetized", "dogs", "."], "h": {"id": "C1415205", "name": "C1415205#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0004234", "name": "C0004234#ent", "pos": [10, 11]}}
{"token": ["Use", "of", "the", "C0012906#ent", "<e1>", "in", "combination", "with", "DNA", "probe", "analysis", "for", "the", "molecular", "genetic", "differentiation", "tick", "spotted", "fever", "and", "C0041472#ent", "<e2>", "group", "rickettsiae", "correlation", "between", "with", "the", "analysis", "of", "polypeptide", "composition", "the", "above", "group", "of", "rickettsiae", "are", "discussed", "."], "h": {"id": "C0012906", "name": "C0012906#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0041472", "name": "C0041472#ent", "pos": [20, 21]}}
{"token": ["C1413904#ent", "<e1>", "is", "a", "C1424798#ent", "<e2>", "to", "cytochrome", "b5", "activates", "Erg11", ",", "so", "that", "cells", "lacking", "C1413904#ent", "<e1>", "accumulate", "the", "Erg11", "substrate", "and", "are", "hypersensitive", "to", "Erg11", "inhibitors", "."], "h": {"id": "C1413904", "name": "C1413904#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1424798", "name": "C1424798#ent", "pos": [4, 5]}}
{"token": ["The", "postmortem", "study", "showed", "edema", ",", "hemorrhage", "and", "congestion", "of", "the", "lungs", ",", "C0002390#ent", "<e1>", ",", "fibrosis", "and", "lobar", "atelectasia", "renal", "tubular", "necrosis", "adrenal", "necrosis", "colestasia", ";", "C2711227#ent", "<e2>", "miocarditis", "."], "h": {"id": "C0002390", "name": "C0002390#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C2711227", "name": "C2711227#ent", "pos": [27, 28]}}
{"token": ["Methazolamide", "may", "be", "an", "effective", "C1254351#ent", "<e1>", "in", "the", "treatment", "of", "some", "patients", "with", "C1414474#ent", "<e2>", "particularly", "those", "with", "head", "and", "voice", "tremor"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1414474", "name": "C1414474#ent", "pos": [14, 15]}}
{"token": ["C2681389#ent", "<e1>", "were", "infected", "with", "C0001486#ent", "<e2>", "encoding", "either", "beta-galactosidase", "(", "control", ")", "or", "Nkx2.5", "."], "h": {"id": "C2681389", "name": "C2681389#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0001486", "name": "C0001486#ent", "pos": [5, 6]}}
{"token": ["There", "were", "five", "C2350386#ent", "<e1>", "of", "esterase", "A", "four", "of", "esterase", "B", "four", "of", "C0014894#ent", "<e2>", "C.", "Eighteen", "distinct", "combinations", "of", "C2350386#ent", "<e1>", "(", "zymotypes", ")", "were", "distinguished", "amongst", "105", "strains", "analysed", "."], "h": {"id": "C0014894", "name": "C0014894#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C2350386", "name": "C2350386#ent", "pos": [3, 4]}}
{"token": ["In", "conclusion", ",", "the", "two", "C0026794#ent", "<e1>", "s", "and", "f", "of", "C0052456#ent", "<e2>", "humans", "purified", "from", "placenta", "and", "liver", ",", "respectively", ",", "have", "similar", "KM", ",", "pI", "'", "and", "native", "molecular", "weight"], "h": {"id": "C0026794", "name": "C0026794#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0052456", "name": "C0052456#ent", "pos": [11, 12]}}
{"token": ["In", "the", "current", "study", "our", "objective", "was", "to", "develop", "a", "murine", "model", "of", "C0272236#ent", "<e1>", "HIDS", ")", "and", "severe", "mevalonic", "aciduria", "MA", ")", ",", "C1290884#ent", "<e2>", "associated", "with", "mevalonate", "kinase", "deficiency", "MKD", ")", "."], "h": {"id": "C0272236", "name": "C0272236#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1290884", "name": "C1290884#ent", "pos": [24, 25]}}
{"token": ["We", "randomly", "assigned", "230", "patients", "in", "sinus", "rhythm", "with", "moderately", "severe", "C0018801#ent", "<e1>", "treatment", "with", "digoxin", ",", "C0600487#ent", "<e2>", ",", "both", ",", "or", "placebo", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [11, 12]}, "relation": "may_be_treated_by", "t": {"id": "C0600487", "name": "C0600487#ent", "pos": [17, 18]}}
{"token": ["While", "the", "volume", "of", "distribution", "of", "amrinone", "appears", "to", "be", "unaffected", "by", "the", "presence", "of", "C0018801#ent", "<e1>", "that", "of", "C0600487#ent", "<e2>", "appears", "to", "be", "somewhat", "enhanced", "."], "h": {"id": "C0018801", "name": "C0018801#ent", "pos": [15, 16]}, "relation": "may_be_treated_by", "t": {"id": "C0600487", "name": "C0600487#ent", "pos": [19, 20]}}
{"token": ["There", "is", "an", "increased", "incidence", "of", "heart", "disease", "patients", "with", "C0027726#ent", "<e1>", "NS", ")", ",", "which", "may", "be", "attributable", "to", "the", "C0162429#ent", "<e2>", "and", "activated", "inflammatory", "state", "the", "sustained", "proteinuria", "."], "h": {"id": "C0027726", "name": "C0027726#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0162429", "name": "C0162429#ent", "pos": [21, 22]}}
{"token": ["Our", "study", "indicated", "that", "either", "C0008783#ent", "<e1>", "or", "bethanechol", "is", "an", "effective", "drug", "in", "treating", "C0014869#ent", "<e2>"], "h": {"id": "C0008783", "name": "C0008783#ent", "pos": [5, 6]}, "relation": "may_treat", "t": {"id": "C0014869", "name": "C0014869#ent", "pos": [15, 16]}}
{"token": ["Hepatic", "C3252639#ent", "<e1>", "mRNA", "was", "inducible", "in", "C0242830#ent", "<e2>", "Creek", "killifish"], "h": {"id": "C3252639", "name": "C3252639#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0242830", "name": "C0242830#ent", "pos": [7, 8]}}
{"token": ["The", "effect", "of", "prazosin", "on", "IOP", "was", "prevented", "by", "systemic", "pretreatment", "with", "phentolamine", "mesylate", ",", "an", "C0001641#ent", "<e1>", "but", "not", "by", "propranolol", "hydrochloride", "C0596005#ent", "<e2>"], "h": {"id": "C0001641", "name": "C0001641#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0596005", "name": "C0596005#ent", "pos": [23, 24]}}
{"token": ["Serum", "C1880904#ent", "<e1>", "NSE", ")", "and", "C0010289#ent", "<e2>", "CK-BB", ")", "were", "measured", "in", "43", "small", "cell", "lung", "cancer", "SCLC", ")", "patients", "."], "h": {"id": "C1880904", "name": "C1880904#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0010289", "name": "C0010289#ent", "pos": [6, 7]}}
{"token": ["The", "disease", "begun", "with", "uncharacteristic", "C3494361#ent", "<e1>", "symptoms", "of", "gastrointestinal", "infection", "by", "headache", "and", "C0042571#ent", "<e2>", "."], "h": {"id": "C3494361", "name": "C3494361#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0042571", "name": "C0042571#ent", "pos": [14, 15]}}
{"token": ["after", "the", "literature", "revision", "the", "autoantibodies", "in", "the", "C0004364#ent", "<e1>", "have", "examined", "the", "cases", "of", "acute", "and", "C0019189#ent", "<e2>", "in", "the", "period", "1972", "-", "1976", "."], "h": {"id": "C0004364", "name": "C0004364#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0019189", "name": "C0019189#ent", "pos": [17, 18]}}
{"token": ["The", "antigens", "for", "the", "C3810599#ent", "<e1>", "blood", "group", "system", "Glycophorins", "A", "B", "(", "GPA", ",", "C1415374#ent", "<e2>", ")", ",", "products", "of", "the", "GPA", "gene", "family"], "h": {"id": "C3810599", "name": "C3810599#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1415374", "name": "C1415374#ent", "pos": [15, 16]}}
{"token": ["In", "addition", "to", "mobilizing", "free", "arachidonate", ",", "C0007262#ent", "<e1>", "induced", "the", "release", "of", "free", "choline", "C0311989#ent", "<e2>", "presumably", "via", "the", "activation", "of", "phospholipases", "C", "D.", "Palmitoyl-L-carnitine", "also", "a", "cytotoxic", "effect", "the", "endothelial", "cells"], "h": {"id": "C0007262", "name": "C0007262#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0311989", "name": "C0311989#ent", "pos": [15, 16]}}
{"token": ["HGF", "alone", "induced", "moderate", "levels", "of", "C0380051#ent", "<e1>", "JNK", ")", "and", "p44/p42", "mitogen-activated", "protein", "kinase", "C1370600#ent", "<e2>", ")", ",", "resulting", "in", "moderate", "levels", "of", "AP-1-DNA", "binding", "activity", "."], "h": {"id": "C0380051", "name": "C0380051#ent", "pos": [6, 7]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1370600", "name": "C1370600#ent", "pos": [15, 16]}}
{"token": ["The", "serum", "concentration", "of", "SLPI", "in", "patients", "with", "C0033581#ent", "<e1>", "correlated", "with", "that", "of", "C-reactive", "protein", "C1879974#ent", "<e2>", ")", "or", "interleukin", "6", "IL-6", ")", "significantly", "but", "not", "strongly", "."], "h": {"id": "C0033581", "name": "C0033581#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1879974", "name": "C1879974#ent", "pos": [16, 17]}}
{"token": ["The", "capA", ",", "capB", ",", "C1537601#ent", "<e1>", ",", "and", "capE", "genes", "all", "necessary", "and", "are", "sufficient", "for", "C0220897#ent", "<e2>", "synthesis", "by", "B.", "anthracis", "."], "h": {"id": "C1537601", "name": "C1537601#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0220897", "name": "C0220897#ent", "pos": [17, 18]}}
{"token": ["The", "technique", "involving", "microacupuncture", ",", "originally", "designed", "manual", "therapeutic", "techniques", "corporal", "acupuncture", "applied", "to", "87", "patients", "with", "neurodystrophic", "syndromes", "of", "C0029429#ent", "<e1>", "patients", "with", "brachioclavicular", "periarthrosis", ",", "C0014488#ent", "<e2>", "styloiditis", "."], "h": {"id": "C0029429", "name": "C0029429#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0014488", "name": "C0014488#ent", "pos": [27, 28]}}
{"token": ["The", "management", "of", "female", "C0376571#ent", "<e1>", "gene", "carriers", "intensive", "surveillance", "prophylactic", "surgery", "the", "use", "of", "C0039286#ent", "<e2>", "."], "h": {"id": "C0376571", "name": "C0376571#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0039286", "name": "C0039286#ent", "pos": [15, 16]}}
{"token": ["C0038220#ent", "<e1>", "AS", ")", "is", "a", "prolonged", ",", "generalized", ",", "and", "C0877017#ent", "<e2>", "may", "occur", "in", "various", "circumstances", "."], "h": {"id": "C0038220", "name": "C0038220#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0877017", "name": "C0877017#ent", "pos": [11, 12]}}
{"token": ["Intradural", "spinal", "arteriovenous", "malformations", "been", "associated", "with", "C0751003#ent", "<e1>", "that", "present", "with", "subarachnoid", "hemorrhage", "with", "C0042345#ent", "<e2>", "produce", "mass", "effect", "but", "spinal", "DAVFs", "have", "not", "previously", "been", "described", "in", "association", "with", "feeding", "artery", "aneurysms"], "h": {"id": "C0751003", "name": "C0751003#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [15, 16]}}
{"token": ["Besides", "acute", "cholystitis", "was", "gangrene", "of", "gallbladder", "in", "10", ",", "C0701818#ent", "<e1>", "in", "7", "and", "C0008732#ent", "<e2>", "without", "perforation", "in", "7", "cases", "."], "h": {"id": "C0701818", "name": "C0701818#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008732", "name": "C0008732#ent", "pos": [15, 16]}}
{"token": ["We", "diagnosed", "and", "treated", "5", "children", "with", "huge", "bladders", "and", "C0020295#ent", "<e1>", "secondary", "to", "polyuria", ",", "resulting", "from", "either", "familial", "nephrogenic", "diabetes", "insipidus", "medullary", "cystic", "disease", "C0687720#ent", "<e2>", "secondary", "to", "panhypopituitarism", "or", "psychogenic", "polydipsia"], "h": {"id": "C0020295", "name": "C0020295#ent", "pos": [10, 11]}, "relation": "manifestation_of", "t": {"id": "C0687720", "name": "C0687720#ent", "pos": [26, 27]}}
{"token": ["C1413134#ent", "<e1>", "mRNA", "levels", "were", "unaffected", "by", "C0072970#ent", "<e2>", "administration", "."], "h": {"id": "C1413134", "name": "C1413134#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0072970", "name": "C0072970#ent", "pos": [7, 8]}}
{"token": ["On", "the", "other", "hand", ",", "no", "inhibition", "of", "CYP2B6-mediated", "7-benzyloxyresorufin", "O-debenzylation", ",", "CYP2D6-mediated", "C0054212#ent", "<e1>", "1'-hydroxylation", ",", "or", "CYP2E1-mediated", "chlorzoxazone", "6-hydroxylation", "by", "C0132512#ent", "<e2>", "at", "40", "microM", "concentration", "was", "observed", "."], "h": {"id": "C0054212", "name": "C0054212#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0132512", "name": "C0132512#ent", "pos": [22, 23]}}
{"token": ["However", ",", "three", "patients", "of", "the", "bulbar", "group", "significant", "SDB", ",", "and", "the", "patterns", "of", "C0520679#ent", "<e1>", "suggested", "that", "both", "bulbar", "weakness", "minimal", "diaphragmatic", "weakness", "cause", "SDB", "in", "C1704945#ent", "<e2>", "patients", "at", "an", "early", "clinical", "stage"], "h": {"id": "C0520679", "name": "C0520679#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1704945", "name": "C1704945#ent", "pos": [28, 29]}}
{"token": ["Usual", "etiologies", "include", "an", "C0027121#ent", "<e1>", "optic", "nerve", "sheath", "meningioma", "sphenoid", "wing", "meningioma", "exterioration", "of", "a", "C0030469#ent", "<e2>", "or", "an", "orbital", "tumor", "it", "primary", "or", "secondary", "."], "h": {"id": "C0027121", "name": "C0027121#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0030469", "name": "C0030469#ent", "pos": [16, 17]}}
{"token": ["Other", "approaches", "focus", "on", "C3540790#ent", "<e1>", "that", "cut", "inside", "the", "Abeta", "sequence", "as", "C3811065#ent", "<e2>", "and", "neprilysin", "."], "h": {"id": "C3540790", "name": "C3540790#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3811065", "name": "C3811065#ent", "pos": [13, 14]}}
{"token": ["We", "report", "here", "a", "one-step", "PCR", "amplification", "of", "the", "C1413868#ent", "<e1>", "human", "genomic", "DNA", "the", "detection", "of", "intact", "C1828472#ent", "<e2>", "restriction", "enzyme", "digestion"], "h": {"id": "C1413868", "name": "C1413868#ent", "pos": [9, 10]}, "relation": "gene_encodes_gene_product", "t": {"id": "C1828472", "name": "C1828472#ent", "pos": [18, 19]}}
{"token": ["Twelve", "nucleotide", "substitutions", "resulting", "in", "four", "amino", "acid", "changes", ",", "were", "identified", "in", "the", "DUMC136", "CYP51", "gene", "comparison", "with", "a", "reported", "C4277553#ent", "<e1>", "sequence", "from", "a", "C2987364#ent", "<e2>", ",", "fluconazole-susceptible", "C.", "albicans", "strain", "."], "h": {"id": "C4277553", "name": "C4277553#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C2987364", "name": "C2987364#ent", "pos": [26, 27]}}
{"token": ["Positive", "predictors", "for", "successful", "treatment", "were", "migraine", "as", "primary", "headache", "C0009088#ent", "<e1>", "less", "than", "10", "years", ",", "and", "regular", "intake", "C0014710#ent", "<e2>", "."], "h": {"id": "C0009088", "name": "C0009088#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0014710", "name": "C0014710#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "the", "distribution", "of", "a", "C1705969#ent", "<e1>", "polymorphism", "in", "110", "Japanese", "patients", "with", "C0011854#ent", "<e2>", "and", "200", "control", "subjects"], "h": {"id": "C1705969", "name": "C1705969#ent", "pos": [6, 7]}, "relation": "gene_associated_with_disease", "t": {"id": "C0011854", "name": "C0011854#ent", "pos": [14, 15]}}
{"token": ["Iodide", "exerted", "a", "modest", "inhibition", "of", "photohemolysis", "and", "loss", "of", "C0234238#ent", "<e1>", "sensitized", "by", "C3811108#ent", "<e2>", ",", "but", "had", "virtually", "no", "influence", "on", "sensitization", "by", "EYMA", "."], "h": {"id": "C0234238", "name": "C0234238#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C3811108", "name": "C3811108#ent", "pos": [14, 15]}}
{"token": ["Examples", "include", "the", "C0058980#ent", "<e1>", "PKR", "that", "functions", "in", "dsRNA", "signaling", "and", "host", "defense", "virus", "infection", "C1309483#ent", "<e2>", ",", "which", "is", "implicated", "in", "RNA", "interference", "RNAi", ")", "-mediated", "gene", "silencing"], "h": {"id": "C0058980", "name": "C0058980#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1309483", "name": "C1309483#ent", "pos": [16, 17]}}
{"token": ["In", "the", "gastroschisis", "plus", "methylene", "blue", "polymer", "(", "G+MBLP", ")", "group", ",", "C3273859#ent", "<e1>", "was", "placed", "into", "C1412050#ent", "<e2>", "after", "gastroschisis", "was", "created", "."], "h": {"id": "C3273859", "name": "C3273859#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1412050", "name": "C1412050#ent", "pos": [17, 18]}}
{"token": ["Induction", "of", "expression", "of", "the", "mutant", "C0005220#ent", "<e1>", "caused", "a", "measurable", "increase", "in", "C0101555#ent", "<e2>", "intracellular", "proteolytic", "activity", "resulted", "in", "no", "significant", "in", "ATP-independent", "proteolytic", "activity"], "h": {"id": "C0005220", "name": "C0005220#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0101555", "name": "C0101555#ent", "pos": [13, 14]}}
{"token": ["C1413784#ent", "<e1>", "expression", "of", "C0669365#ent", "<e2>", "active", "NFATc4", "in", "nfatc3-/-nfatc4-/-", "embryos", "prolongs", "embryonic", "viability", "embryonic", "day", "12", "and", "preserves", "ventricular", "myocyte", "proliferation", "compact", "zone", "density", ",", "and", "trabecular", "formation", "."], "h": {"id": "C1413784", "name": "C1413784#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0669365", "name": "C0669365#ent", "pos": [4, 5]}}
{"token": ["The", "average", "level", "of", "C1419396#ent", "<e1>", ",", "but", "not", "C1332751#ent", "<e2>", ",", "mRNA", "expression", "was", "statistically", "higher", "metastatic", "biopsies", "compared", "with", "primary", "tumour", "biopsies", "."], "h": {"id": "C1419396", "name": "C1419396#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1332751", "name": "C1332751#ent", "pos": [9, 10]}}
{"token": ["Lysine", "9", "of", "histone", "H3", "H3K9", ")", "is", "deacetylated", "by", "the", "C0960948#ent", "<e1>", "methylated", "by", "a", "C0062776#ent", "<e2>", "HMT", ")", "and", "then", "bound", "by", "a", "chromodomain-containing", "protein", "such", "as", "heterochromatin", "protein", "1", "HP1", ")", ",", "leading", "to", "transcriptional", "repression"], "h": {"id": "C0960948", "name": "C0960948#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0062776", "name": "C0062776#ent", "pos": [16, 17]}}
{"token": ["The", "C0243460#ent", "<e1>", "PKI", ")", "mRNA", "and", "protein", "are", "negatively", "and", "C1420295#ent", "<e2>", "regulated", "in", "the", "kidney", "by", "1", "alpha", ",", "25(OH)2D3", "."], "h": {"id": "C0243460", "name": "C0243460#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [11, 12]}}
{"token": ["Therefore", ",", "the", "aims", "of", "the", "present", "study", "were", "to", "compare", "the", "efficacy", "and", "safety", "of", "C1415900#ent", "<e1>", "alone", "or", "in", "combination", "with", "C0002404#ent", "<e2>", "nonresponders", "to", "previous", "C1415900#ent", "<e1>", "monotherapy", "."], "h": {"id": "C1415900", "name": "C1415900#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0002404", "name": "C0002404#ent", "pos": [23, 24]}}
{"token": ["Sorsby", "'s", "pseudo-inflammatory", "dystrophy", "and", "C0344297#ent", "<e1>", "autosomal", "dominant", "while", "gyrate", "atrophy", "the", "choroid", "and", "retina", "is", "autosomal", "recessive", "C0008525#ent", "<e2>", "intermediate", "sex-linked", "."], "h": {"id": "C0344297", "name": "C0344297#ent", "pos": [5, 6]}, "relation": "manifestation_of", "t": {"id": "C0008525", "name": "C0008525#ent", "pos": [19, 20]}}
{"token": ["In", "conclusion", ",", "our", "data", "indicate", "that", "specific", "IgA", "is", "intrathecally", "produced", "in", "herpes", "simplex", "encephalitis", "herpes", "zoster", "C0026780#ent", "<e1>", "is", "a", "rare", "finding", "in", "C0948264#ent", "<e2>", "."], "h": {"id": "C0026780", "name": "C0026780#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0948264", "name": "C0948264#ent", "pos": [25, 26]}}
{"token": ["This", "adhI", "mutant", "expressed", "high", "levels", "of", "a", "novel", "C3659502#ent", "<e1>", "AdhI", ")", "that", "uses", "ethanol", ",", "C0001964#ent", "<e2>", "and", "2-propanol", "as", "substrates", "."], "h": {"id": "C3659502", "name": "C3659502#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0001964", "name": "C0001964#ent", "pos": [17, 18]}}
{"token": ["In", "C0017601#ent", "<e1>", ",", "reactive", "astrocytes", "in", "the", "optic", "nerve", "head", "C1533698#ent", "<e2>", "which", "apparently", "produces", "excessive", "nitric", "oxide", "damages", "the", "axons", "."], "h": {"id": "C0017601", "name": "C0017601#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1533698", "name": "C1533698#ent", "pos": [11, 12]}}
{"token": ["Functional", "studies", "demonstrated", "that", "transcriptional", "activation", "a", "plasmid", "containing", "multimerized", "kappaB", "sites", "by", "C1420556#ent", "<e1>", "was", "inhibited", "by", "C0035064#ent", "<e2>", "that", "elevate", "cAMP", "and", "by", "overexpression", "of", "the", "catalytic", "subunit", "PKA", "."], "h": {"id": "C1420556", "name": "C1420556#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [18, 19]}}
{"token": ["Transcription", "of", "the", "structural", "gene", "glutamine", "synthetase", "glnA", ")", "in", "C0519030#ent", "<e1>", "controlled", "by", "the", "nitrogen", "regulatory", "genes", "C1424887#ent", "<e2>", ",", "ntrB", "and", "ntrC.", "The", "nucleotide", "sequence", "the", "regulatory", "region", "of", "the", "glnA", "gene", "is", "reported", "here", "."], "h": {"id": "C0519030", "name": "C0519030#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C1424887", "name": "C1424887#ent", "pos": [18, 19]}}
{"token": ["The", "activities", "of", "C0003039#ent", "<e1>", "p-nitroanisole-O-demethylase", "increased", "whereas", "ethoxyresorufin-O-dealkylase", "activity", "much", "less", "induced", "and", "C0059735#ent", "<e2>", "decreased", "."], "h": {"id": "C0003039", "name": "C0003039#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0059735", "name": "C0059735#ent", "pos": [14, 15]}}
{"token": ["Common", "clinical", "signs", "associated", "with", "ureteral", "obstruction", "abnormalities", "in", "urination", ",", "persistent", "C0262655#ent", "<e1>", "abdominal", "pain", "vomiting", ",", "anorexia", ",", "weight", "loss", "and", "depression", "or", "C0023380#ent", "<e2>", "."], "h": {"id": "C0262655", "name": "C0262655#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0023380", "name": "C0023380#ent", "pos": [25, 26]}}
{"token": ["In", "a", "prostate", "cancer", "cell", "line", "C1366526#ent", "<e1>", ",", "mevastatin", "treatment", "led", "to", "elevated", "levels", "of", "C1420626#ent", "<e2>", "and", "caused", "a", "small", "increase", "in", "the", "C1420626#ent", "<e2>", "associated", "with", "cdk2", "."], "h": {"id": "C1366526", "name": "C1366526#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420626", "name": "C1420626#ent", "pos": [16, 17]}}
{"token": ["The", "open", "reading", "frames", "the", "C4284182#ent", "<e1>", "1263", "bp", "encoding", "a", "protein", "of", "420", "C3539947#ent", "<e2>", "and", "the", "PRBI", "gene", "(", "1683", "bp", "encoding", "a", "protein", "of", "560", "C3539947#ent", "<e2>", "were", "found", "."], "h": {"id": "C4284182", "name": "C4284182#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3539947", "name": "C3539947#ent", "pos": [14, 15]}}
{"token": ["We", "have", "recently", "reported", "that", "mammalian", "pancreatic", "group", "I", "phospholipase", "A2", "C1333201#ent", "<e1>", ")", "has", "its", "specific", "receptor", "(", "C0031667#ent", "<e2>", "on", "a", "variety", "of", "mammalian", "cells", "that", "various", "biological", "responses", "elicited", "by", "C1333201#ent", "<e1>", "via", "this", "receptor", "."], "h": {"id": "C1333201", "name": "C1333201#ent", "pos": [11, 12]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C0031667", "name": "C0031667#ent", "pos": [19, 20]}}
{"token": ["This", "study", "was", "a", "double-blind", ",", "placebo-controlled", "parallel", "group", "study", "oral", "C0064113#ent", "<e1>", "or", "placebo", "for", "8", "weeks", "in", "patients", "with", "C0406326#ent", "<e2>"], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0406326", "name": "C0406326#ent", "pos": [21, 22]}}
{"token": ["The", "patient", "was", "a", "13-year-old", "boy", "with", "C4285064#ent", "<e1>", "who", "presented", "with", "C0403397#ent", "<e2>", "and", "cyclosporine-resistant", "nephrotic", "syndrome", "and", "hyperlipidemia", "."], "h": {"id": "C4285064", "name": "C4285064#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0403397", "name": "C0403397#ent", "pos": [12, 13]}}
{"token": ["Immunoblotting", "reveals", "that", "repeated", "low", "doses", "C2348308#ent", "<e1>", "results", "in", "activation", "of", "C0291573#ent", "<e2>", "implying", "induction", "of", "apoptosis", "."], "h": {"id": "C2348308", "name": "C2348308#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0291573", "name": "C0291573#ent", "pos": [12, 13]}}
{"token": ["We", "found", "that", "monoamine", "oxidase", "A", "C3657721#ent", "<e1>", ")", "was", "the", "most", "significantly", "up-regulated", "C0079429#ent", "<e2>", "."], "h": {"id": "C3657721", "name": "C3657721#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [14, 15]}}
{"token": ["These", "10", "proteins", "include", "alpha-1-antrypsin", ",", "apolipoprotein", "A-I", "cystatin", "A", "SA", ",", "SA-III", ",", "and", "SN", ",", "enolase", "I", "hemoglobin", "beta-chain", "C0633227#ent", "<e1>", "as", "well", "as", "a", "C1418587#ent", "<e2>"], "h": {"id": "C0633227", "name": "C0633227#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C1418587", "name": "C1418587#ent", "pos": [27, 28]}}
{"token": ["Following", "attachment", "to", "CEA", ",", "C0623362#ent", "<e1>", "cleavage", "of", "the", "C0017343#ent", "<e2>", "at", "the", "cell", "surface", "the", "scFv", "and", "proline-rich", "hinge", "allowing", "transduction", "."], "h": {"id": "C0623362", "name": "C0623362#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0017343", "name": "C0017343#ent", "pos": [10, 11]}}
{"token": ["We", "found", "that", "expression", "of", "the", "mRNA", "and", "protein", "of", "the", "glial", "glutamate", "transporters", "GLAST", "and", "C2985245#ent", "<e1>", "were", "down-regulated", "in", "the", "C0205812#ent", "<e2>", "acid-administered", "group", "."], "h": {"id": "C2985245", "name": "C2985245#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0205812", "name": "C0205812#ent", "pos": [22, 23]}}
{"token": ["There", "has", "been", "an", "increasing", "awareness", "recently", "of", "subtle", ",", "non-bleeding", "gastrointestinal", "conditions", "may", "result", "in", "abnormal", "iron", "absorption", "to", "iron-deficiency", "anaemia", "C3889248#ent", "<e1>", ")", "in", "the", "absence", "of", "C0426575#ent", "<e2>"], "h": {"id": "C3889248", "name": "C3889248#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0426575", "name": "C0426575#ent", "pos": [29, 30]}}
{"token": ["Sera", "used", "for", "this", "study", "were", "obtained", "from", "healthy", "blood", "donors", "from", "patients", "with", "one", "of", "the", "following", ":", "systemic", "candidiasis", "C0004030#ent", "<e1>", ",", "cryptococcosis", ",", "toxoplasmosis", ",", "or", "C0024530#ent", "<e2>", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0024530", "name": "C0024530#ent", "pos": [29, 30]}}
{"token": ["The", "Pkh2", "phosphorylation", "site", "in", "C3538849#ent", "<e1>", "(", "Thr-983", ")", "is", "part", "of", "a", "conserved", "C2000212#ent", "<e2>", "target", "motif", "and", "essential", "for", "C3538849#ent", "<e1>", "function", "."], "h": {"id": "C3538849", "name": "C3538849#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2000212", "name": "C2000212#ent", "pos": [15, 16]}}
{"token": ["Forty-five", "amino", "acid", "residues", "of", "the", "mature", "protein", "of", "C1097401#ent", "<e1>", "entirely", "independent", "of", "other", "C0752243#ent", "<e2>", "."], "h": {"id": "C1097401", "name": "C1097401#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0752243", "name": "C0752243#ent", "pos": [15, 16]}}
{"token": ["We", "investigated", "the", "effects", "of", "C0751039#ent", "<e1>", "on", "renal", "microvessels", "the", "efficacy", "of", "C2348358#ent", "<e2>", "or", "ETA/ETB", "receptor", "antagonists", "in", "ameliorating", "C0751039#ent", "<e1>", "effects", "in", "the", "hydronephrotic", "rat", "kidney", "."], "h": {"id": "C0751039", "name": "C0751039#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C2348358", "name": "C2348358#ent", "pos": [13, 14]}}
{"token": ["Risk", "factors", "C0038454#ent", "<e1>", "children", "include", "congenital", "heart", "malformations", "C0042373#ent", "<e2>", ",", "infectious", "diseases", "collagen", "tissue", "diseases", "and", "metabolic", "disorders"], "h": {"id": "C0038454", "name": "C0038454#ent", "pos": [2, 3]}, "relation": "related_to", "t": {"id": "C0042373", "name": "C0042373#ent", "pos": [9, 10]}}
{"token": ["Phosphorylation", "of", "synapsin", "I", "the", "COOH-terminal", "region", "Ca(2+)/calmodulin-dependent", "protein", "kinase", "II", "C0170168#ent", "<e1>", "the", "binding", "to", "the", "SH3", "domains", "amphiphysins", "I/II", ",", "C0812252#ent", "<e2>", ",", "and", "alpha-spectrin", "without", "affecting", "the", "high", "affinity", "interactions", "."], "h": {"id": "C0170168", "name": "C0170168#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0812252", "name": "C0812252#ent", "pos": [22, 23]}}
{"token": ["The", "structures", "indicate", "that", "C1414262#ent", "<e1>", "belongs", "to", "the", "C3890046#ent", "<e2>", "serine", "proteases", "cleaves", "substrates", "after", "acidic", "residues", "."], "h": {"id": "C1414262", "name": "C1414262#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C3890046", "name": "C3890046#ent", "pos": [9, 10]}}
{"token": ["In", "the", "first", "place", "are", "chorioiditis", "(", "C0701807#ent", "<e1>", ",", "iritis", "and", "iridocyclitis", "(", "C0042165#ent", "<e2>", ",", "uveitis", "totalis", "periphlebitis", "retinae", "by", "far", "less", "frequent", "."], "h": {"id": "C0701807", "name": "C0701807#ent", "pos": [7, 8]}, "relation": "has_nichd_parent", "t": {"id": "C0042165", "name": "C0042165#ent", "pos": [14, 15]}}
{"token": ["The", "most", "common", "indication", "for", "C0175699#ent", "<e1>", "is", "the", "failed", "C0024031#ent", "<e2>", "leg", "pain"], "h": {"id": "C0175699", "name": "C0175699#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0024031", "name": "C0024031#ent", "pos": [10, 11]}}
{"token": ["Cyclic", "C0009450#ent", "<e1>", "particularly", "reliable", "immunity", "are", "certain", "C0042769#ent", "<e2>", "such", "as", "measles", ",", "poliomyelitis", "and", "yellow", "fever"], "h": {"id": "C0009450", "name": "C0009450#ent", "pos": [1, 2]}, "relation": "related_to", "t": {"id": "C0042769", "name": "C0042769#ent", "pos": [8, 9]}}
{"token": ["Subsequently", ",", "etoposide", "caused", "activation", "of", "C1704796#ent", "<e1>", ",", "cleavage", "of", "C1426354#ent", "<e2>", ",", "and", "dephosphorylation", "of", "Chk1", "."], "h": {"id": "C1704796", "name": "C1704796#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1426354", "name": "C1426354#ent", "pos": [11, 12]}}
{"token": ["Circulating", "levels", "of", "angiotensin", "II", "ANGII", ")", ",", "a", "powerful", "C0042397#ent", "<e1>", "are", "frequently", "increased", "in", "C0008679#ent", "<e2>"], "h": {"id": "C0042397", "name": "C0042397#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0008679", "name": "C0008679#ent", "pos": [16, 17]}}
{"token": ["From", "this", ",", "a", "series", "of", "important", "C0017337#ent", "<e1>", "related", "to", "the", "C1413950#ent", "<e2>", "metabolism", "and", "detoxification", "were", "discovered", ",", "such", "as", "P450", "gene", "glutathione", "S-transferase", "gene", "sterol", "carrier", "protein", "2", "gene", "."], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413950", "name": "C1413950#ent", "pos": [12, 13]}}
{"token": ["C0073096#ent", "<e1>", "exhibited", "stronger", "antiradical", "activity", "than", "kaempferol", "and", "C0068450#ent", "<e2>", "and", "was", "also", "more", "efficient", "than", "alpha-tocopherol", ",", "a", "known", "strong", "endogenous", "non-flavonoid", "antioxidant", ",", "used", "for", "comparison", "."], "h": {"id": "C0073096", "name": "C0073096#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0068450", "name": "C0068450#ent", "pos": [9, 10]}}
{"token": ["Interestingly", ",", "the", "gastric", "lesions", "by", "C1707163#ent", "<e1>", "cell", "invasion", "improved", "by", "the", "administration", "of", "C0003392#ent", "<e2>", "5", "out", "of", "9", "patients", "."], "h": {"id": "C1707163", "name": "C1707163#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003392", "name": "C0003392#ent", "pos": [15, 16]}}
{"token": ["The", "universality", "of", "pyridinoline", "crosslinks", "skeletal", "damage", "markers", "has", "been", "confirmed", "by", "establishing", "a", "significant", "correlation", "between", "drug", "and", "therapeutic", "effect", "Pyd", "and", "C1366555#ent", "<e1>", "only", ",", "in", "patients", "receiving", "C0772244#ent", "<e2>", "."], "h": {"id": "C1366555", "name": "C1366555#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0772244", "name": "C0772244#ent", "pos": [30, 31]}}
{"token": ["C0143266#ent", "<e1>", "reduced", "the", "rotational", "response", "the", "C3889128#ent", "<e2>", "agonist", "SKF", "38393", "in", "a", "dose-dependent", "manner", "."], "h": {"id": "C0143266", "name": "C0143266#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C3889128", "name": "C3889128#ent", "pos": [7, 8]}}
{"token": ["Thus", "the", "induction", "of", "p53", "using", "C1443643#ent", "<e1>", "provide", "a", "new", "approach", "in", "the", "treatment", "of", "C0003873#ent", "<e2>", "."], "h": {"id": "C1443643", "name": "C1443643#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [16, 17]}}
{"token": ["Serum", "and", "C1176140#ent", "<e1>", "SGK1", ")", "was", "among", "the", "most", "up-regulated", "C0017337#ent", "<e2>", "following", "APC", "knockdown", "through", "small", "interfering", "RNA"], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0017337", "name": "C0017337#ent", "pos": [11, 12]}}
{"token": ["Finally", ",", "a", "significant", "increase", "in", "PUT", "and", "C3273505#ent", "<e1>", "excretion", "was", "observed", "after", "severe", "C0020615#ent", "<e2>", "due", "to", "the", "infusion", "of", "insulin", "."], "h": {"id": "C3273505", "name": "C3273505#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0020615", "name": "C0020615#ent", "pos": [15, 16]}}
{"token": ["C0018364#ent", "<e1>", "has", "amino", "acid", "sequence", "to", "other", "3", "'", "C0015284#ent", "<e2>", "including", "ExoI.", "These", "results", "suggest", "that", "C0018364#ent", "<e1>", "possess", "a", "3", "'", "DNase", "activity", "of", "substituting", "for", "ExoI", "in", "the", "recombinational", "repair", "UV-induced", "lesions", "."], "h": {"id": "C0015284", "name": "C0015284#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0018364", "name": "C0018364#ent", "pos": [0, 1]}}
{"token": ["The", "patient", "had", "been", "prescribed", "six", "psychotropic", "medications", "i.e.", ",", "thiothixene", ",", "lithium", ",", "C0886883#ent", "<e1>", "amitriptyline", ",", "benztropine", ",", "and", "C0040805#ent", "<e2>", "effects", "."], "h": {"id": "C0886883", "name": "C0886883#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0040805", "name": "C0040805#ent", "pos": [21, 22]}}
{"token": ["This", "assumption", "is", "further", "supported", "by", "the", "demonstration", "of", "structural", "and", "functional", "homology", "between", "the", "extracellular", "loop", "the", "C3813215#ent", "<e1>", "the", "M7", "and", "C0021699#ent", "<e2>", "and", "the", "P-loops", "of", "Na+", "channels", "."], "h": {"id": "C3813215", "name": "C3813215#ent", "pos": [18, 19]}, "relation": "gene_product_has_chemical_classification", "t": {"id": "C0021699", "name": "C0021699#ent", "pos": [23, 24]}}
{"token": ["Daily", "C0342384#ent", "<e1>", "exposure", "induces", "neuronal", "death", "C1706269#ent", "<e2>", "and", "non-NR1", "neurons", ",", "but", "the", "neuronal", "phenotype", "is", "consistent", "within", "affected", "brainstem", "nuclei"], "h": {"id": "C0342384", "name": "C0342384#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1706269", "name": "C1706269#ent", "pos": [7, 8]}}
{"token": ["The", "group", "of", "C0018939#ent", "<e1>", "complicated", "by", "SIO", "to", "the", "contrary", "of", "C0018995#ent", "<e2>", "is", "very", "heterogeneous", "."], "h": {"id": "C0018939", "name": "C0018939#ent", "pos": [3, 4]}, "relation": "related_to", "t": {"id": "C0018995", "name": "C0018995#ent", "pos": [12, 13]}}
{"token": ["The", "zinc-finger", "gene-7", "(", "C1421823#ent", "<e1>", ")", "was", "located", "90", "kb", "3", "'", "of", "C0086661#ent", "<e2>", "on", "human", "chromosome", "8", "band", "q24", "by", "pulsed-field", "gel", "electrophoresis", "PFGE", ")", "."], "h": {"id": "C1421823", "name": "C1421823#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0086661", "name": "C0086661#ent", "pos": [14, 15]}}
{"token": ["This", "group", "of", "paratuberculous", "nephritis", "of", "seriously", "C0231218#ent", "<e1>", "patients", ",", "all", "cases", "with", "common", "symptoms", "of", "C0031065#ent", "<e2>", "(", "edemas", ",", "hypertension", ",", "hematuria", ")", "and", "all", "cases", "with", "changes", "in", "serous", "cavities"], "h": {"id": "C0231218", "name": "C0231218#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0031065", "name": "C0031065#ent", "pos": [17, 18]}}
{"token": ["Furthermore", ",", "cytokine", "stimulation", "C0166027#ent", "<e1>", "and", "TIMP-1", "gene", "expressions", "be", "enhanced", "or", "blocked", "by", "C0021246#ent", "<e2>", ",", "respectively", ",", "and", "reversed", "by", "exogenous", "PGE2", "."], "h": {"id": "C0166027", "name": "C0166027#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0021246", "name": "C0021246#ent", "pos": [15, 16]}}
{"token": ["Expression", "of", "the", "chimera", ",", "but", "not", "that", "of", "the", "wild", "type", "C1663627#ent", "<e1>", "or", "of", "a", "C0211705#ent", "<e2>", "inactive", "form", "of", "the", "chimera", ",", "induced", "the", "differentiation", "of", "PC12", "cells"], "h": {"id": "C1663627", "name": "C1663627#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C0211705", "name": "C0211705#ent", "pos": [17, 18]}}
{"token": ["Accordingly", ",", "PTX", "also", "interfered", "with", "early", "cell", "activation", "such", "as", "the", "rise", "in", "intracellular", "Ca2", "+", "and", "the", "activation", "of", "the", "C1420232#ent", "<e1>", "antiporter", "induced", "by", "C0030779#ent", "<e2>", "and", "phorbol", "esters", "respectively", "."], "h": {"id": "C1420232", "name": "C1420232#ent", "pos": [22, 23]}, "relation": "NA", "t": {"id": "C0030779", "name": "C0030779#ent", "pos": [27, 28]}}
{"token": ["We", "report", "a", "43-year-old", "C0022972#ent", "<e1>", "female", "who", "was", "symptomatic", "until", "she", "developed", "proteinuria", "from", "C0027726#ent", "<e2>", "which", "caused", "a", "marked", "drop", "in", "acetylcholine", "receptor", "antibody", "titer", "with", "remission", "of", "myasthenia", "."], "h": {"id": "C0022972", "name": "C0022972#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [15, 16]}}
{"token": ["Clinical", "AR", "C4283882#ent", "<e1>", "are", "similar", "histologic", "lesions", "a", "capacity", "for", "C1334912#ent", "<e2>", "progression", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1334912", "name": "C1334912#ent", "pos": [11, 12]}}
{"token": ["Stimulation", "of", "Bac1.2F5", "macrophage", "cells", "with", "lipopolysaccharide", "was", "found", "to", "induce", "gradual", "and", "persistent", "tyrosine", "phosphorylation", "C0008163#ent", "<e1>", "in", "an", "C0038085#ent", "<e2>", "manner", "."], "h": {"id": "C0008163", "name": "C0008163#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0038085", "name": "C0038085#ent", "pos": [20, 21]}}
{"token": ["Recent", "studies", "have", "established", "essential", "roles", "of", "protein", "kinase", "C0000608#ent", "<e1>", "in", "signaling", "pathways", "various", "functions", "of", "microfilaments", "and", "C1334214#ent", "<e2>", "modulating", "multiple", "cytoskeletal", "proteins"], "h": {"id": "C0000608", "name": "C0000608#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334214", "name": "C1334214#ent", "pos": [19, 20]}}
{"token": ["The", "results", "demonstrate", "that", "heterologous", "C0001492#ent", "<e1>", "desensitization", "can", "precede", "the", "development", "of", "C0242350#ent", "<e2>", "later", "stages", "and", "can", "occur", "independently", "of", "changes", "in", "beta-adrenergic", "receptors"], "h": {"id": "C0001492", "name": "C0001492#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0242350", "name": "C0242350#ent", "pos": [13, 14]}}
{"token": ["Specific", "glycan", "structures", "terminal", "GalNAc", "moieties", ",", "expressed", "by", "the", "human", "C0018889#ent", "<e1>", "Schistosoma", "mansoni", "well", "as", "tumor", "antigens", "a", "subset", "of", "C0017083#ent", "<e2>", ",", "were", "identified", "as", "ligands", "for", "MGL", "."], "h": {"id": "C0018889", "name": "C0018889#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0017083", "name": "C0017083#ent", "pos": [22, 23]}}
{"token": ["Tris", ",", "C0070276#ent", "<e1>", "and", "turanose", "inhibited", "C0002272#ent", "<e2>", "from", "all", "the", "three", "tissues", ",", "but", "turanose", "inhibited", "the", "spleen", "and", "liver", "enzymes", "a", "higher", "degree", "than", "the", "intestinal", "enzyme", "."], "h": {"id": "C0070276", "name": "C0070276#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0002272", "name": "C0002272#ent", "pos": [7, 8]}}
{"token": ["Association", "constants", "recombinant", "Leu-8-CMTI", "I", "with", "bovine", "C0005289#ent", "<e1>", "and", "human", "C1413814#ent", "<e2>", "the", "same", ",", "within", "experimental", "error", "as", "for", "CMTI", "I", "isolated", "from", "a", "natural", "source"], "h": {"id": "C0005289", "name": "C0005289#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1413814", "name": "C1413814#ent", "pos": [11, 12]}}
{"token": ["In", "the", "C0034372#ent", "<e1>", "patients", ",", "after", "C0001640#ent", "<e2>", "blockade", "with", "thymoxamine", "(", "1", "mg", "kg-1", "h-1", ")", ",", "twice", "the", "dose", "of", "intravenous", "noradrenaline", "was", "needed", "to", "induce", "the", "same", "pressor", "response"], "h": {"id": "C0034372", "name": "C0034372#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0001640", "name": "C0001640#ent", "pos": [7, 8]}}
{"token": ["Thus", ",", "we", "assume", "that", "chondrocytes", "are", "depending", "on", "the", "adaptive", "functions", "of", "C1333897#ent", "<e1>", "in", "order", "to", "maintain", "C1705556#ent", "<e2>", "levels", "and", "thereby", "matrix", "synthesis", "the", "course", "of", "osteoarthritis", "."], "h": {"id": "C1333897", "name": "C1333897#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1705556", "name": "C1705556#ent", "pos": [19, 20]}}
{"token": ["This", "study", "was", "designed", "to", "investigate", "structural", "and", "functional", "changes", "in", "the", "left", "ventricle", "subjects", "at", "high", "risk", "C0007222#ent", "<e1>", "to", "assess", "their", "prognostic", "value", "respect", "to", "C0010068#ent", "<e2>"], "h": {"id": "C0007222", "name": "C0007222#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0010068", "name": "C0010068#ent", "pos": [27, 28]}}
{"token": ["Although", "glyceryl", "trinitrate", "C1704693#ent", "<e1>", ")", "is", "a", "C0013227#ent", "<e2>", "that", "easily", "permeates", "through", "skin", ",", "the", "variations", "in", "its", "transepidermal", "fluxes", "were", "high", "."], "h": {"id": "C1704693", "name": "C1704693#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0013227", "name": "C0013227#ent", "pos": [8, 9]}}
{"token": ["A(1)R", "agonist", "activation", "of", "C1420170#ent", "<e1>", "occurs", "in", "both", "C0669372#ent", "<e2>", "and", "FAO", "cells", ",", "which", "express", "Kir6.1", ",", "Kir6.2", ",", "SUR1", ",", "SUR2A", ",", "and", "SUR2B", "mRNA", "channel", "subunits", "."], "h": {"id": "C1420170", "name": "C1420170#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0669372", "name": "C0669372#ent", "pos": [9, 10]}}
{"token": ["A", "method", "for", "the", "determination", "of", "C0770456#ent", "<e1>", "was", "developed", "in", "which", "the", "C0020924#ent", "<e2>", "C0770456#ent", "<e1>", "was", "acylated", "with", "heptafluorobutyric", "anhydride", "using", "triethylamine", "as", "a", "catalyst", "."], "h": {"id": "C0770456", "name": "C0770456#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0020924", "name": "C0020924#ent", "pos": [13, 14]}}
{"token": ["Ondansetron", ",", "a", "5-HT3", "receptor", "antagonist", "as", "C0206046#ent", "<e1>", ",", "is", "a", "safe", "and", "effective", "C0003297#ent", "<e2>", "used", "extensively", "in", "oncology", "and", "postoperative", "patients", "."], "h": {"id": "C0206046", "name": "C0206046#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0003297", "name": "C0003297#ent", "pos": [15, 16]}}
{"token": ["During", "ADP", "plus", "C0101555#ent", "<e1>", "inactivation", "of", "pyruvate", ",", "C0034352#ent", "<e2>", "chloroplast", "extracts", "32P", "was", "incorporated", "into", "the", "enzyme", "from", "[beta-32P]ADP", "."], "h": {"id": "C0101555", "name": "C0101555#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0034352", "name": "C0034352#ent", "pos": [9, 10]}}
{"token": ["In", "the", "case", "of", "the", "biphasic", "responses", "to", "C2744579#ent", "<e1>", ",", "clonidine", "seemed", "to", "block", "only", "the", "C0003289#ent", "<e2>"], "h": {"id": "C2744579", "name": "C2744579#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0003289", "name": "C0003289#ent", "pos": [17, 18]}}
{"token": ["C0023264#ent", "<e1>", ",", "thus", ",", "offers", "C0003216#ent", "<e2>", "blocking", "acid", "secretion", "inhibition", "of", "H(+)K(+)ATPase", "and", "decrease", "of", "gastrin", "secretion", "."], "h": {"id": "C0023264", "name": "C0023264#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0003216", "name": "C0003216#ent", "pos": [6, 7]}}
{"token": ["HLA-DR5", "was", "associated", "with", "mild", "forms", "C0003864#ent", "<e1>", "and", "with", "absence", "of", ",", "or", "only", "mild", ",", "C0042166#ent", "<e2>", "."], "h": {"id": "C0003864", "name": "C0003864#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042166", "name": "C0042166#ent", "pos": [17, 18]}}
{"token": ["C0032460#ent", "<e1>", "PCOS", ")", "is", "associated", "with", "C0004153#ent", "<e2>"], "h": {"id": "C0032460", "name": "C0032460#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0004153", "name": "C0004153#ent", "pos": [7, 8]}}
{"token": ["Nowadays", "15", "C0567439#ent", "<e1>", "diseases", "caused", "by", "these", "mutations", "are", "known", "such", "as", "C0206064#ent", "<e2>", "FRA", "X", "E", "syndrome", "Kennedy", "syndrome", "spinobulbare", "muscle", "atrophy", "Curschmann-Steinert", "syndrome", "myotonic", "dystrophia", "Huntington", "disease", "Friedreich", "ataxia", "spinocerebellare", "ataxias", "types", ",", "II", ".", ","], "h": {"id": "C0567439", "name": "C0567439#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0206064", "name": "C0206064#ent", "pos": [13, 14]}}
{"token": ["before", "and", "12", "weeks", "after", "adding", "levetiracetam", "to", "the", "regimen", "of", "6", "subjects", "on", "C0031507#ent", "<e1>", "monotherapy", "for", "C0014544#ent", "<e2>", "."], "h": {"id": "C0031507", "name": "C0031507#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0014544", "name": "C0014544#ent", "pos": [18, 19]}}
{"token": ["Here", ",", "we", "show", "that", "at", "a", "subset", "of", "the", "JXP", ",", "PSD-93", "colocalizes", "with", "C2347280#ent", "<e1>", ",", "K(+", ")", "channels", "and", "its", "related", "C1422550#ent", "<e2>", "PSD-95", ")", "."], "h": {"id": "C2347280", "name": "C2347280#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1422550", "name": "C1422550#ent", "pos": [24, 25]}}
{"token": ["Aboriginal", "children", "living", "in", "remote", "Australia", "experience", "high", "rates", "of", "bacterial", "infection", "as", "trachoma", ",", "C0029882#ent", "<e1>", "streptococcal", "skin", "infection", "which", "often", "progress", "to", "associated", "C1561643#ent", "<e2>", "later", "life", "."], "h": {"id": "C0029882", "name": "C0029882#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1561643", "name": "C1561643#ent", "pos": [25, 26]}}
{"token": ["A", "kinetic-potentiometric", "procedure", "for", "the", "determination", "of", "pyridoxine", "in", "the", "presence", "of", "thiamine", "in", "C1720946#ent", "<e1>", "based", "on", "its", "reaction", "with", "C0038623#ent", "<e2>", ",", "is", "presented", "."], "h": {"id": "C1720946", "name": "C1720946#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0038623", "name": "C0038623#ent", "pos": [21, 22]}}
{"token": ["C1413796#ent", "<e1>", ",", "a", "'", "neuronal-specific", "'", "catenin", ",", "and", "C1332803#ent", "<e2>", "mRNAs", "were", "abundant", "in", "both", "DLPFC", "and", "hippocampus", ",", "with", "a", "distinct", "neuronal", "localization"], "h": {"id": "C1413796", "name": "C1413796#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1332803", "name": "C1332803#ent", "pos": [10, 11]}}
{"token": ["The", "effect", "of", "insulin", "on", "the", "serum", "levels", "of", "the", "amino-terminal", "propeptide", "of", "type", "III", "procollagen", "PIIINP", ")", "was", "investigated", "in", "patients", "with", "C0011854#ent", "<e1>", "whose", "disease", "was", "unsatisfactorily", "controlled", "C0035064#ent", "<e2>"], "h": {"id": "C0011854", "name": "C0011854#ent", "pos": [23, 24]}, "relation": "NA", "t": {"id": "C0035064", "name": "C0035064#ent", "pos": [30, 31]}}
{"token": ["1-O-Octadecyl-2-O-methyl-glycerophosphocholine", "(", "C0044549#ent", "<e1>", ")", "is", "an", "C0014996#ent", "<e2>", "lipid", "with", "selective", "antiproliferative", "properties", "mechanism", "of", "action", "is", "still", "unresolved", "."], "h": {"id": "C0044549", "name": "C0044549#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0014996", "name": "C0014996#ent", "pos": [7, 8]}}
{"token": ["Both", "presented", "with", "C0206157#ent", "<e1>", "and", "bone", "pain", "and", "showed", "hypophosphatemia", ",", "C0268559#ent", "<e2>", ",", "reduced", "tubular", "phosphate", "reabsorption", "TPR", ")", ",", "increased", "hydroxyprolinuria", "and", "normal", "iPTH", "and", "iCT", "values", "."], "h": {"id": "C0206157", "name": "C0206157#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0268559", "name": "C0268559#ent", "pos": [12, 13]}}
{"token": ["Also", "the", "effect", "of", "GSTT1", "gene", "polymorphism", "on", "smoking-related", "C3813548#ent", "<e1>", "showed", "the", "same", "tendency", "as", "C1738886#ent", "<e2>", "OR", ",", "2.00", ",", "CI", ",", "1.05", "-", "3.84", ")", "."], "h": {"id": "C3813548", "name": "C3813548#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1738886", "name": "C1738886#ent", "pos": [16, 17]}}
{"token": ["C0042769#ent", "<e1>", "in", "acute", "hearing", "loss", "rubella", ",", "measles", ",", "mumps", ",", "C0019360#ent", "<e2>", "cytomegalovirus", "and", "influenza", "."], "h": {"id": "C0042769", "name": "C0042769#ent", "pos": [0, 1]}, "relation": "related_to", "t": {"id": "C0019360", "name": "C0019360#ent", "pos": [12, 13]}}
{"token": ["The", "promoter", "region", "C1415619#ent", "<e1>", "shows", "a", "polymorphism", "with", "different", "(", "C1704693#ent", "<e2>", ")", "n", "repeats", "that", "has", "been", "reported", "to", "differently", "induce", "gene", "expression"], "h": {"id": "C1415619", "name": "C1415619#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1704693", "name": "C1704693#ent", "pos": [11, 12]}}
{"token": ["Molecular", "biologic", "techniques", "revealed", "that", "elevation", "of", "mRNA", "for", "cellular", "retinoic", "acid", "binding", "protein", "II", "a", "retinoid-related", "event", "and", "that", "nuclear", "receptors", "as", "retinoic", "acid", "receptors", "C3536891#ent", "<e1>", "X-receptors", "may", "transduce", "the", "C1514917#ent", "<e2>"], "h": {"id": "C3536891", "name": "C3536891#ent", "pos": [26, 27]}, "relation": "NA", "t": {"id": "C1514917", "name": "C1514917#ent", "pos": [32, 33]}}
{"token": ["Among", "C0265316#ent", "<e1>", "coarctation", "of", "the", "abdominal", "aorta", "C0035067#ent", "<e2>", "traditionally", "been", "associated", "with", "neurofibromatosis", "."], "h": {"id": "C0265316", "name": "C0265316#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C0035067", "name": "C0035067#ent", "pos": [8, 9]}}
{"token": ["In", "patients", "with", "diabetes", "mellitus", "the", "content", "of", "plasma", "fibronectin", "out", "to", "be", "higher", "depending", "on", "the", "C0025229#ent", "<e1>", "the", "presence", "of", "C2733158#ent", "<e2>", ",", "and", "status", "of", "compensation", "."], "h": {"id": "C0025229", "name": "C0025229#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C2733158", "name": "C2733158#ent", "pos": [22, 23]}}
{"token": ["The", "effects", "of", "gold", "sodium", "thiomalate", "C1428159#ent", "<e1>", ")", "on", "the", "production", "of", "specific", "C0962754#ent", "<e2>", "by", "thioglycolate-elicited", "macrophages", "was", "investigated", "."], "h": {"id": "C1428159", "name": "C1428159#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0962754", "name": "C0962754#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "blockade", "of", "adenosine", "A1", "receptors", "C0917964#ent", "<e1>", "long-term", "potentiation", ",", "and", "activation", "of", "C0757191#ent", "<e2>", "a", "form", "of", "long-term", "potentiation", "which", "is", "different", "from", "that", "induced", "by", "tetanic", "stimulation"], "h": {"id": "C0917964", "name": "C0917964#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0757191", "name": "C0757191#ent", "pos": [17, 18]}}
{"token": ["Thus", ",", "C1095795#ent", "<e1>", "and", "other", "plant", "flavonoids", "have", "potential", "as", "C0034540#ent", "<e2>", "apoptosis", "through", "scavenging", "ROS", "upon", "cerebral", "or", "myocardial", "diseases", "associated", "with", "free", "radical", "generation"], "h": {"id": "C1095795", "name": "C1095795#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0034540", "name": "C0034540#ent", "pos": [11, 12]}}
{"token": ["Thirty-five", "patients", "had", "overt", "clinical", "manifestations", "C0022658#ent", "<e1>", "by", "a", "C0027726#ent", "<e2>", "focal", "and", "segmental", "glomerular", "sclerosis", "FSS", ")", "."], "h": {"id": "C0022658", "name": "C0022658#ent", "pos": [6, 7]}, "relation": "nichd_parent_of", "t": {"id": "C0027726", "name": "C0027726#ent", "pos": [10, 11]}}
{"token": ["Hemolytic", "uremic", "syndrome", "HUS", ")", "was", "the", "commonest", "cause", "of", "ARF", "(", "30.8", "%", ")", "followed", "by", "acute", "tubular", "necrosis", "C0268494#ent", "<e1>", ")", "in", "28.84", "%", "and", "C0156221#ent", "<e2>", "19.23", "%", "."], "h": {"id": "C0268494", "name": "C0268494#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [27, 28]}}
{"token": ["Only", "1", "of", "C2316810#ent", "<e1>", "patients", "showed", "defective", "response", "to", "C1161352#ent", "<e2>", "whereas", "the", "remaining", "had", "a", "normal", "response", "suggesting", "an", "afferent", "lesion", "alone", "."], "h": {"id": "C2316810", "name": "C2316810#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1161352", "name": "C1161352#ent", "pos": [10, 11]}}
{"token": ["All", "five", "patients", "in", "the", "codeine", "phosphate", "arm", "adequate", "control", ",", "while", "the", "five", "patients", "allocated", "to", "the", "C0353946#ent", "<e1>", "all", "crossed-over", "to", "C0009217#ent", "<e2>", "resolution", "of", "their", "diarrhoea", "."], "h": {"id": "C0353946", "name": "C0353946#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0009217", "name": "C0009217#ent", "pos": [23, 24]}}
{"token": ["Two", "patients", "are", "described", "in", "whom", "the", "absorption", "of", "C1881373#ent", "<e1>", "was", "impaired", "by", "C0013231#ent", "<e2>", "nutritional", "remedies"], "h": {"id": "C1881373", "name": "C1881373#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013231", "name": "C0013231#ent", "pos": [14, 15]}}
{"token": ["The", "280-kD", "cation-independent", "mannose-6-phosphate", "receptor", "C4284033#ent", "<e1>", ")", "has", "been", "shown", "to", "play", "a", "role", "in", "endocytic", "uptake", "of", "C1567160#ent", "<e2>", "since", "target", "cells", "overexpressing", "C4284033#ent", "<e1>", "have", "an", "increased", "sensitivity", "to", "granzyme", "B-mediated", "apoptosis"], "h": {"id": "C1567160", "name": "C1567160#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C4284033", "name": "C4284033#ent", "pos": [5, 6]}}
{"token": ["In", "this", "report", "the", "importance", "of", "typhoid", "hepatitis", "its", "clinical", "significance", "the", "diagnosis", "of", "C0041466#ent", "<e1>", "highlighted", ",", "particularly", "at", "places", "where", "viral", "hepatitis", "C0002438#ent", "<e2>", "usually", "common", "and", "C0041466#ent", "<e1>", "endemic", "."], "h": {"id": "C0002438", "name": "C0002438#ent", "pos": [24, 25]}, "relation": "NA", "t": {"id": "C0041466", "name": "C0041466#ent", "pos": [14, 15]}}
{"token": ["However", ",", "other", "studies", "question", "the", "thrombotic", "relevance", "of", "both", "C1423896#ent", "<e1>", "and", "PZ", "C0268487#ent", "<e2>", "."], "h": {"id": "C1423896", "name": "C1423896#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [14, 15]}}
{"token": ["We", "have", "recently", "shown", "that", "C0001047#ent", "<e1>", "(", "NAC", ")", "at", "0.4", "mM", "prevents", "C0020823#ent", "<e2>", "nephrotoxicity", "in", "vitro"], "h": {"id": "C0001047", "name": "C0001047#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0020823", "name": "C0020823#ent", "pos": [14, 15]}}
{"token": ["Four", "main", "categories", "of", "possible", "therapeuticals", "are", "considered", ":", "inhibitors", "of", "C0633225#ent", "<e1>", "endogenous", "antioxidants", "and", "their", "precursors", ",", "C3714649#ent", "<e2>", "and", "related", "compounds", ",", "other", "natural", "antioxidants", "fruits", "and", "vegetables", "."], "h": {"id": "C0633225", "name": "C0633225#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C3714649", "name": "C3714649#ent", "pos": [19, 20]}}
{"token": ["C0008325#ent", "<e1>", "evaluated", "by", "quantitation", "of", "luminal", "water", "transport", "C0027021#ent", "<e2>"], "h": {"id": "C0008325", "name": "C0008325#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0027021", "name": "C0027021#ent", "pos": [9, 10]}}
{"token": ["C0174045#ent", "<e1>", "in", "various", "important", "signaling", "pathways", "have", "been", "implicated", "in", "C1417574#ent", "<e2>"], "h": {"id": "C0174045", "name": "C0174045#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1417574", "name": "C1417574#ent", "pos": [11, 12]}}
{"token": ["These", "data", "suggest", "a", "negative", "regulatory", "role", "for", "C3539645#ent", "<e1>", "phosphorylation", "of", "C1417857#ent", "<e2>", "."], "h": {"id": "C3539645", "name": "C3539645#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C1417857", "name": "C1417857#ent", "pos": [12, 13]}}
{"token": ["Airway", "obstruction", "induced", "by", "AMP", "or", "C1413662#ent", "<e1>", "was", "not", "inhibited", "by", "the", "H1", "receptor", "antagonist", "C0034282#ent", "<e2>", "(", "1", "mg", "kg(-1", ")", ")", "in", "passively", "sensitised", "guinea-pigs", "."], "h": {"id": "C1413662", "name": "C1413662#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0034282", "name": "C0034282#ent", "pos": [16, 17]}}
{"token": ["Sarcoma-45", "actin", "was", "found", "to", "contain", "beta-", "and", "gamma-actin", "isoforms", "and", "an", "unusual", "C0597298#ent", "<e1>", "which", "appeared", "to", "be", "more", "C0815040#ent", "<e2>", "than", "the", "alpha-actin", "C0597298#ent", "<e1>", "."], "h": {"id": "C0815040", "name": "C0815040#ent", "pos": [20, 21]}, "relation": "NA", "t": {"id": "C0597298", "name": "C0597298#ent", "pos": [13, 14]}}
{"token": ["Intriguingly", ",", "ARNIP", ",", "and", "in", "particular", "its", "RING-H2", "domain", ",", "functioned", "as", "a", "C1307637#ent", "<e1>", "in", "vitro", "the", "presence", "of", "a", "specific", "ubiquitin-conjugating", "enzyme", "C1421274#ent", "<e2>", "-", "1", "."], "h": {"id": "C1307637", "name": "C1307637#ent", "pos": [14, 15]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1421274", "name": "C1421274#ent", "pos": [25, 26]}}
{"token": ["Here", ",", "we", "report", "the", "identification", "of", "serum", "and", "C1176140#ent", "<e1>", "SGK", ")", "as", "a", "cellular", "protein", "physically", "interacts", "with", "C1334481#ent", "<e2>", "."], "h": {"id": "C1176140", "name": "C1176140#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1334481", "name": "C1334481#ent", "pos": [20, 21]}}
{"token": ["The", "lowest", "doses", "of", "the", "extract", "significantly", "decreased", "the", "levels", "of", "lipoperoxides", ",", "and", "C0669516#ent", "<e1>", "increased", "to", "a", "similar", "extent", "as", "with", "C0771315#ent", "<e2>", "(", "P<0.001", ")", "."], "h": {"id": "C0669516", "name": "C0669516#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0771315", "name": "C0771315#ent", "pos": [23, 24]}}
{"token": ["In", "summary", ",", "itraconazole", "showed", "activity", "in", "human", "studies", "of", "C0004030#ent", "<e1>", ",", "cryptococcosis", "and", "C0019655#ent", "<e2>", "with", "minimal", "toxicity", "."], "h": {"id": "C0004030", "name": "C0004030#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0019655", "name": "C0019655#ent", "pos": [15, 16]}}
{"token": ["C3888082#ent", "<e1>", "fusion", "was", "not", "evident", "by", "FISH", ",", "but", "the", "C1366536#ent", "<e2>", "signal", "was", "split", "in", "74.5", "%", "of", "cells", "."], "h": {"id": "C3888082", "name": "C3888082#ent", "pos": [0, 1]}, "relation": "related_to_genetic_biomarker", "t": {"id": "C1366536", "name": "C1366536#ent", "pos": [11, 12]}}
{"token": ["Newer", "antifungal", "agents", "including", "less", "toxic", "lipid", "preparations", "of", "AmBD", ",", "triazoles", "and", "the", "C1268551#ent", "<e1>", ",", "have", "been", "added", "to", "our", "armamentarium", "against", "C1688637#ent", "<e2>", "."], "h": {"id": "C1268551", "name": "C1268551#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1688637", "name": "C1688637#ent", "pos": [24, 25]}}
{"token": ["Mutations", "of", "the", "C1335077#ent", "<e1>", "adrenal", "hypoplasia", "congenita", "an", "X-linked", "disorder", "by", "adrenal", "insufficiency", "C0271623#ent", "<e2>"], "h": {"id": "C1335077", "name": "C1335077#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0271623", "name": "C0271623#ent", "pos": [14, 15]}}
{"token": ["Out", "of", "28", "with", "early", "evidence", "of", "C0035344#ent", "<e1>", "four", "had", "progressed", "to", "C0271217#ent", "<e2>", "the", "remaining", "24", "had", "at", "least", "a", "corrected", "visual", "acuity", "0.4", "at", "disposal", "."], "h": {"id": "C0035344", "name": "C0035344#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0271217", "name": "C0271217#ent", "pos": [13, 14]}}
{"token": ["The", "29", "positive", "cases", "were", "further", "studied", "using", "primers", "specific", "for", "either", "C1420434#ent", "<e1>", "or", "SSX2", ";", "19", "cases", "were", "positive", "for", "C1839329#ent", "<e2>", "and", "10", "for", "SYT-SSX2", "."], "h": {"id": "C1420434", "name": "C1420434#ent", "pos": [12, 13]}, "relation": "genetic_biomarker_related_to", "t": {"id": "C1839329", "name": "C1839329#ent", "pos": [22, 23]}}
{"token": ["In", "addition", ",", "C0383779#ent", "<e1>", "and", "mitochondrial", "permeability", "transition", "pore", "MPTP", ")", "inhibitors", "such", "as", "cyclosporin", "A", "C0751039#ent", "<e2>", ")", "and", "bongkrekic", "acid", "BA", ")", "did", "not", "block", "the", "release", "of", "cytochrome", "c", "mitochondria", "."], "h": {"id": "C0383779", "name": "C0383779#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0751039", "name": "C0751039#ent", "pos": [17, 18]}}
{"token": ["A", "considerable", "morbidity", "was", "found", ",", "not", "only", "in", "patients", "with", "primary", "viral", "encephalitis", "but", "also", "in", "patients", "with", "C0014038#ent", "<e1>", "of", "unknown", "aetiology", "and", "C0596773#ent", "<e2>"], "h": {"id": "C0014038", "name": "C0014038#ent", "pos": [19, 20]}, "relation": "nichd_parent_of", "t": {"id": "C0596773", "name": "C0596773#ent", "pos": [25, 26]}}
{"token": ["C1413916#ent", "<e1>", "DbetaH", ")", "deficiency", "is", "a", "very", "rare", "form", "of", "C0037019#ent", "<e2>", "by", "a", "complete", "absence", "of", "noradrenaline", "and", "adrenaline", "in", "plasma", "together", "with", "increased", "dopamine", "plasma", "levels", "."], "h": {"id": "C1413916", "name": "C1413916#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0037019", "name": "C0037019#ent", "pos": [11, 12]}}
{"token": ["These", "findings", "demonstrate", "that", "marked", "C3714552#ent", "<e1>", "in", "severely", "C0221166#ent", "<e2>", "patients", "with", "multiple", "sclerosis", "the", "weakness", "increases", "as", "the", "upper", "extremities", "increasingly", "involved", "."], "h": {"id": "C3714552", "name": "C3714552#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0221166", "name": "C0221166#ent", "pos": [9, 10]}}
{"token": ["C0087097#ent", "<e1>", "is", "displaced", ",", "in", "vitro", "from", "plasma", "proteins", "C1742019#ent", "<e2>"], "h": {"id": "C0087097", "name": "C0087097#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1742019", "name": "C1742019#ent", "pos": [10, 11]}}
{"token": ["The", "experimental", "rats", "received", "subcutaneous", "injections", "C0031479#ent", "<e1>", "manufactured", "by", "Sigma", "for", "the", "C2926735#ent", "<e2>", "of", "3", "days", "."], "h": {"id": "C0031479", "name": "C0031479#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C2926735", "name": "C2926735#ent", "pos": [13, 14]}}
{"token": ["We", "now", "report", "potentials", "evoked", "by", "C0030193#ent", "<e1>", "cutaneous", "stimulation", "with", "a", "CO2", "laser", "C1416825#ent", "<e2>", ")", "and", "recorded", "from", "subdural", "electrodes", "the", "medial", "wall", "the", "hemisphere", "."], "h": {"id": "C0030193", "name": "C0030193#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1416825", "name": "C1416825#ent", "pos": [14, 15]}}
{"token": ["C0040558#ent", "<e1>", ",", "filariasis", "and", "C0023290#ent", "<e2>", "."], "h": {"id": "C0040558", "name": "C0040558#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [5, 6]}}
{"token": ["Each", "group", "was", "divided", "into", "two", "subgroups", "receiving", "either", "C0003753#ent", "<e1>", "(", "ARE", ")", ",", "or", "ovine", "CRH", "C1705056#ent", "<e2>", ")", "stimulation", "tests"], "h": {"id": "C0003753", "name": "C0003753#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1705056", "name": "C1705056#ent", "pos": [18, 19]}}
{"token": ["We", "concluded", "that", "xenon", "and", "aerosol", "lung-imaging", "studies", "are", "sensitive", "and", "useful", "screening", "procedures", "detecting", "evidence", "of", "early", "localized", "C0600260#ent", "<e1>", "for", "locating", "regional", "abnormalities", "the", "airways", "of", "patients", "with", "C0035204#ent", "<e2>"], "h": {"id": "C0600260", "name": "C0600260#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0035204", "name": "C0035204#ent", "pos": [30, 31]}}
{"token": ["C1259141#ent", "<e1>", "(", "biricodar", ",", "VX-710", ")", "restores", "drug", "sensitivity", "P-glycoprotein", "and", "C0919458#ent", "<e2>"], "h": {"id": "C1259141", "name": "C1259141#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0919458", "name": "C0919458#ent", "pos": [12, 13]}}
{"token": ["A", "standardized", "palpatory", "examination", "determined", "whether", "there", "were", "specific", "motion", "asymmetries", "centered", "at", "spinal", "segments", "C1419009#ent", "<e1>", ",", "T2", ",", "and", "T6", "and", "confirmed", "by", "C1851100#ent", "<e2>", "motion", "asymmetries", "in", "adjacent", "segments", "."], "h": {"id": "C1419009", "name": "C1419009#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1851100", "name": "C1851100#ent", "pos": [25, 26]}}
{"token": ["C1332125#ent", "<e1>", "is", "a", "multifunctional", "protein", "regulating", "Wnt", "signaling", "the", "C0248813#ent", "<e2>", "JNK/SAPK", ")", "pathway", "as", "well", "as", "tumorigenesis", "."], "h": {"id": "C1332125", "name": "C1332125#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0248813", "name": "C0248813#ent", "pos": [10, 11]}}
{"token": ["The", "protein", ",", "designated", "C3539650#ent", "<e1>", ",", "is", "a", "member", "of", "the", "C1417249#ent", "<e2>", "contains", "a", "putative", "collagen-binding", "(", "fibronectin", "type", "II)", "in", "addition", "to", "8", "C-type", "carbohydrate", "recognition", "domains"], "h": {"id": "C3539650", "name": "C3539650#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1417249", "name": "C1417249#ent", "pos": [12, 13]}}
{"token": ["These", "patients", "are", "at", "a", "high", "risk", "C0004623#ent", "<e1>", "mainly", "spontaneous", "ascitis", "infection", "or", "C0341503#ent", "<e2>", "pneumonia", ",", "or", "pleural", "empyema"], "h": {"id": "C0004623", "name": "C0004623#ent", "pos": [7, 8]}, "relation": "nichd_parent_of", "t": {"id": "C0341503", "name": "C0341503#ent", "pos": [14, 15]}}
{"token": ["C0027583#ent", "<e1>", "intestinal", "infestation", "and", "granulomas", "of", "C0023049#ent", "<e2>", "common", "in", "several", "organs", "."], "h": {"id": "C0027583", "name": "C0027583#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0023049", "name": "C0023049#ent", "pos": [7, 8]}}
{"token": ["Using", "immunohistochemistry", ",", "C0134982#ent", "<e1>", "was", "detected", "in", "C0003873#ent", "<e2>", "synovial", "tissue", "ST", ")", ",", "primarily", "in", "the", "synovial", "intimal", "lining", "."], "h": {"id": "C0134982", "name": "C0134982#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0003873", "name": "C0003873#ent", "pos": [8, 9]}}
{"token": ["The", "decreased", "plasma", "AA", "concentration", "and", "granulation", "tissue", "activity", "in", "C0011849#ent", "<e1>", "can", "also", "be", "normalized", "by", "the", "aldose", "reductase", "C0076808#ent", "<e2>", "."], "h": {"id": "C0011849", "name": "C0011849#ent", "pos": [10, 11]}, "relation": "NA", "t": {"id": "C0076808", "name": "C0076808#ent", "pos": [20, 21]}}
{"token": ["We", "investigated", "the", "effects", "of", "cimetidine", "and", "C0028978#ent", "<e1>", "on", "angiogenesis", "in", "granulation", "tissue", "on", "the", "healing", "of", "C0038358#ent", "<e2>", "induced", "by", "acetic", "acid", "rats", "."], "h": {"id": "C0028978", "name": "C0028978#ent", "pos": [7, 8]}, "relation": "may_treat", "t": {"id": "C0038358", "name": "C0038358#ent", "pos": [18, 19]}}
{"token": ["9", "of", "our", "patients", "died", "from", "C0006111#ent", "<e1>", "stroke", "due", "to", "infarction", "4", "stroke", "due", "to", "hemorrhage", "1", "C0014038#ent", "<e2>", "head", "injury", "1", "brain", "tumor", "1", "."], "h": {"id": "C0006111", "name": "C0006111#ent", "pos": [6, 7]}, "relation": "related_to", "t": {"id": "C0014038", "name": "C0014038#ent", "pos": [18, 19]}}
{"token": ["orally", ")", "for", "persistent", "penile", "erection", "priapism", "resulting", "from", "injection", "of", "pharmacological", "agents", "such", "as", "C0733398#ent", "<e1>", ",", "phenoxybenzamine", "and", "C0030350#ent", "<e2>", ",", "into", "the", "penis", "for", "erectile", "impotence"], "h": {"id": "C0733398", "name": "C0733398#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0030350", "name": "C0030350#ent", "pos": [20, 21]}}
{"token": ["C0410190#ent", "<e1>", "EDMD", ")", "is", "a", "rare", "hereditary", "X-linked", "disease", "by", "progressive", "C0030552#ent", "<e2>", "cardiac", "conduction", "defects", "arrhythmias", "."], "h": {"id": "C0410190", "name": "C0410190#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0030552", "name": "C0030552#ent", "pos": [12, 13]}}
{"token": ["Various", "psychiatric", "syndromes", "been", "described", "either", "as", "C0029166#ent", "<e1>", "cerebral", "malaria", "part", "of", "post", "malaria", "C4287919#ent", "<e2>"], "h": {"id": "C0029166", "name": "C0029166#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C4287919", "name": "C4287919#ent", "pos": [15, 16]}}
{"token": ["We", "describe", "two", "patients", "with", "temporal", "artery", "amyloidosis", "presenting", "with", "symptoms", "of", "jaw", "claudication", "visual", "disturbance", ",", "and", "C1850794#ent", "<e1>", "suggestive", "of", "giant", "cell", "arteritis", "C1423891#ent", "<e2>", ")", "and", "polymyalgia", "rheumatica"], "h": {"id": "C1850794", "name": "C1850794#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C1423891", "name": "C1423891#ent", "pos": [25, 26]}}
{"token": ["Analysis", "of", "C0026900#ent", "<e1>", "putative", "response", "elements", "one", "preferred", "binding", "site", "intron", "1", "the", "C1335671#ent", "<e2>"], "h": {"id": "C0026900", "name": "C0026900#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1335671", "name": "C1335671#ent", "pos": [14, 15]}}
{"token": ["These", "results", "suggest", "that", "isolated", "mitochondria", "are", "capable", "of", "synthesizing", "three", "subunits", "of", "C0010760#ent", "<e1>", "assembling", "them", "into", "a", "C0282109#ent", "<e2>", "."], "h": {"id": "C0010760", "name": "C0010760#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0282109", "name": "C0282109#ent", "pos": [19, 20]}}
{"token": ["Apart", "from", "stricture", "formation", ",", "marked", "C0014869#ent", "<e1>", "coarsened", "folds", "may", "lead", "to", "a", "mistaken", "diagnosis", "of", "C0042345#ent", "<e2>", "or", "carcinoma", "."], "h": {"id": "C0014869", "name": "C0014869#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0042345", "name": "C0042345#ent", "pos": [17, 18]}}
{"token": ["Most", "notably", "C0023899#ent", "<e1>", "was", "particularly", "rich", "in", "PBR-I", "yet", "contained", "no", "detectable", "C3657721#ent", "<e2>", "."], "h": {"id": "C0023899", "name": "C0023899#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3657721", "name": "C3657721#ent", "pos": [13, 14]}}
{"token": ["These", "IPSP", "waves", "induced", "in", "both", "types", "of", "C1851710#ent", "<e1>", "were", "decreased", "in", "amplitude", "by", "iontophoresed", "C0005372#ent", "<e2>", "but", "not", "by", "strychnine", "."], "h": {"id": "C1851710", "name": "C1851710#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0005372", "name": "C0005372#ent", "pos": [16, 17]}}
{"token": ["The", "clinical", "and", "pathological", "findings", "suggest", "that", "the", "disorder", "should", "be", "distinguished", "from", "C0338451#ent", "<e1>", "as", "well", "as", "from", "other", "C0019151#ent", "<e2>"], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0019151", "name": "C0019151#ent", "pos": [20, 21]}}
{"token": ["Digestion", "was", "performed", "with", "the", "enzymes", "Sst", "II", ",", "Mlu", "I", ",", "and", "Pvu", "I", "and", "hybridization", "with", "C0038304#ent", "<e1>", ",", "DRA", ",", "DQB", ",", "C0301362#ent", "<e2>", "and", "DPA", "probes", "."], "h": {"id": "C0038304", "name": "C0038304#ent", "pos": [18, 19]}, "relation": "NA", "t": {"id": "C0301362", "name": "C0301362#ent", "pos": [25, 26]}}
{"token": ["The", "Par", "proteins", "C1335190#ent", "<e1>", ")", "Par3", "and", "Par6", ",", "plus", "atypical", "protein", "kinase", "C", "C3539645#ent", "<e2>", ")", "function", "in", "the", "formation", "or", "maintenance", "of", "TJs", "and", "more", "generally", "in", "metazoan", "cell", "polarity", "."], "h": {"id": "C1335190", "name": "C1335190#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3539645", "name": "C3539645#ent", "pos": [15, 16]}}
{"token": ["Kartagener's", "syndrome", "KS", ")", "is", "a", "C0019247#ent", "<e1>", "typical", "symptoms", "of", "situs", "inversus", "bronchiectasis", ",", "and", "C0151317#ent", "<e2>", "the", "nasal", "mucosa"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0151317", "name": "C0151317#ent", "pos": [16, 17]}}
{"token": ["However", ",", "C0074112#ent", "<e1>", "produced", "histological", "evidence", "(", "reduced", "numbers", "of", "C0064833#ent", "<e2>", "of", "anti-colitic", "efficacy", "an", "eight-week", "treatment", "period", "in", "CTTs", "with", "persistent", "active", "colitis"], "h": {"id": "C0074112", "name": "C0074112#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0064833", "name": "C0064833#ent", "pos": [11, 12]}}
{"token": ["The", "combined", "activity", "of", "C0076110#ent", "<e1>", "plus", "itraconazole", "or", "plus", "C0393080#ent", "<e2>", "was", "synergic", "against", "17", "%", "of", "the", "strains", "."], "h": {"id": "C0076110", "name": "C0076110#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0393080", "name": "C0393080#ent", "pos": [10, 11]}}
{"token": ["In", "an", "attempt", "to", "improve", "our", "understanding", "of", "this", "C1951340#ent", "<e1>", ",", "we", "have", "cloned", ",", "sequenced", "and", "characterized", "the", "C0079429#ent", "<e2>", "encoding", "the", "Pla", "phenotypes", "in", "Y.", "pestis", "and", "examined", "its", "temperature-dependent", "regulation"], "h": {"id": "C1951340", "name": "C1951340#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0079429", "name": "C0079429#ent", "pos": [20, 21]}}
{"token": ["15-deoxy-16-hydroxy-16-vinyl-PGE2", "(", "C0044875#ent", "<e1>", ")", "and", "its", "methyl", "ester", "(", "C0078298#ent", "<e2>", ")", "elicit", "a", "distinct", "and", "persistent", "erythema", "which", "is", "restricted", "to", "the", "area", "of", "and", "is", "not", "associated", "with", "wheal", "."], "h": {"id": "C0044875", "name": "C0044875#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0078298", "name": "C0078298#ent", "pos": [10, 11]}}
{"token": ["66", "%", "homologous", "at", "the", "C2917660#ent", "<e1>", "level", "to", "C1332764#ent", "<e2>", "."], "h": {"id": "C2917660", "name": "C2917660#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1332764", "name": "C1332764#ent", "pos": [9, 10]}}
{"token": ["Exposure", "of", "DCs", "to", "activated", "Vdelta2", "T", "cells", "was", "critical", "for", "C3540579#ent", "<e1>", "T-cell", "priming", "when", "C1705581#ent", "<e2>", "stimulation", "was", "limiting", "."], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1705581", "name": "C1705581#ent", "pos": [16, 17]}}
{"token": ["The", "C1254351#ent", "<e1>", "is", "also", "highly", "effective", "in", "patients", "poorly", "responsive", "to", "C0019593#ent", "<e2>"], "h": {"id": "C1254351", "name": "C1254351#ent", "pos": [1, 2]}, "relation": "nichd_parent_of", "t": {"id": "C0019593", "name": "C0019593#ent", "pos": [12, 13]}}
{"token": ["Furthermore", ",", "NMC", "from", "C4283882#ent", "<e1>", ",", "but", "not", "C1416587#ent", "<e2>", ",", "patients", "induced", "IgE", "synthesis", "by", "purified", "B", "cells", "the", "presence", "of", "Der", "fII", "mite", "antigen", "."], "h": {"id": "C4283882", "name": "C4283882#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1416587", "name": "C1416587#ent", "pos": [9, 10]}}
{"token": ["C1414905#ent", "<e1>", "also", "inhibited", "IL-1beta-induced", "C1337092#ent", "<e2>", "gene", "expression", "in", "human", "mesangial", "cells"], "h": {"id": "C1414905", "name": "C1414905#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1337092", "name": "C1337092#ent", "pos": [5, 6]}}
{"token": ["C3889271#ent", "<e1>", "bound", "to", "C1705001#ent", "<e2>", "was", "not", "tyrosine-phosphorylated", "under", "basal", "conditions", "or", "following", "C1705001#ent", "<e2>", "stimulation", "."], "h": {"id": "C3889271", "name": "C3889271#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705001", "name": "C1705001#ent", "pos": [4, 5]}}
{"token": ["Inhibition", "of", "C1705504#ent", "<e1>", ",", "or", "blockade", "of", "the", "C0914069#ent", "<e2>", "PAF", ")", "receptor", ",", "blocked", "antigen-induced", "airway", "hyperresponsiveness", "suppressed", "eosinophil", "infiltration", "."], "h": {"id": "C1705504", "name": "C1705504#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0914069", "name": "C0914069#ent", "pos": [9, 10]}}
{"token": ["The", "C1423836#ent", "<e1>", "gene", "encodes", "a", "putative", "C2826562#ent", "<e2>", "is", "located", "on", "chromosome", "20q13.13", "13.2", "."], "h": {"id": "C1423836", "name": "C1423836#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C2826562", "name": "C2826562#ent", "pos": [7, 8]}}
{"token": ["By", "contrast", ",", "none", "of", "the", "six", "cases", "of", "t(1;19)-positive", ",", "cIg-", "ALL", "had", "evidence", "of", "rearranged", "E2A", "genomic", "restriction", "fragments", ",", "detectable", "C0289575#ent", "<e1>", "chimeric", "transcripts", ",", "or", "hybrid", "C1867800#ent", "<e2>"], "h": {"id": "C0289575", "name": "C0289575#ent", "pos": [23, 24]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1867800", "name": "C1867800#ent", "pos": [30, 31]}}
{"token": ["PD98059", "and", "C4055175#ent", "<e1>", "enhanced", "Smad3-induced", "ALP", "activity", "and", "mineralization", ",", "whereas", "C0297666#ent", "<e2>", "inhibited", "them", "."], "h": {"id": "C4055175", "name": "C4055175#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0297666", "name": "C0297666#ent", "pos": [12, 13]}}
{"token": ["A", "variety", "of", "systemically", "administered", "drugs", "are", "used", "to", "treat", "C0033860#ent", "<e1>", ",", "including", "methotrexate", ",", "cyclosporine", ",", "acitretin", ",", "and", "C0020402#ent", "<e2>", "."], "h": {"id": "C0033860", "name": "C0033860#ent", "pos": [10, 11]}, "relation": "may_be_treated_by", "t": {"id": "C0020402", "name": "C0020402#ent", "pos": [21, 22]}}
{"token": ["In", "conclusion", ",", "isolated", "C0242422#ent", "<e1>", "is", "unusual", "in", "C1853578#ent", "<e2>", ",", "and", "unlike", "Huntington's", "disease", "cognitive", "changes", "absent", "or", "subtle", "in", "the", "early", "stages"], "h": {"id": "C0242422", "name": "C0242422#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C1853578", "name": "C1853578#ent", "pos": [9, 10]}}
{"token": ["C1822711#ent", "<e1>", "specialized", "protein", "structures", "in", "binding", "of", "phosphoinositides", "(", "C1413284#ent", "<e2>", ")", "."], "h": {"id": "C1822711", "name": "C1822711#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1413284", "name": "C1413284#ent", "pos": [10, 11]}}
{"token": ["Her", "medical", "history", "arterial", "hypertension", "C0025517#ent", "<e1>", "obesity", ",", "Takayasu", "disease", "dermatopolymyositis", ",", "and", "alleged", "allergy", "to", "C0885449#ent", "<e2>", "contrast", "and", "local", "anesthetics"], "h": {"id": "C0025517", "name": "C0025517#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0885449", "name": "C0885449#ent", "pos": [17, 18]}}
{"token": ["However", ",", "in", "the", "present", "study", "the", "D", "allele", "frequency", "not", "increased", "in", "C0034931#ent", "<e1>", "cases", "(", "0.51", "for", "D", "allele", "0.49", "for", "C0002085#ent", "<e2>", "."], "h": {"id": "C0034931", "name": "C0034931#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0002085", "name": "C0002085#ent", "pos": [23, 24]}}
{"token": ["Recently", ",", "a", "homologue", "of", "the", "small", "subunit", "C0035547#ent", "<e1>", "RNR", ")", "was", "discovered", ",", "called", "C3539802#ent", "<e2>", "."], "h": {"id": "C0035547", "name": "C0035547#ent", "pos": [8, 9]}, "relation": "is_biochemical_function_of_gene_product", "t": {"id": "C3539802", "name": "C3539802#ent", "pos": [16, 17]}}
{"token": ["To", "compare", "in", "vivo", "levels", ",", "spatial", "localization", "and", "in", "vitro", "secretion", "of", "C2717970#ent", "<e1>", "cystatin", "C", "cysC", ")", "in", "the", "retinal", "degeneration", "1", "C1418426#ent", "<e2>", ")", "mouse", "model", "retinitis", "pigmentosa", "control", "(", "wt", ")", "mouse", "retinas", "."], "h": {"id": "C2717970", "name": "C2717970#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1418426", "name": "C1418426#ent", "pos": [24, 25]}}
{"token": ["It", "is", "generally", "accepted", "that", "in", "aspirin-induced", "asthma", "AIA", ")", "the", "C0006266#ent", "<e1>", "is", "provoked", "by", "inhibition", "of", "prostaglandin", "synthesis", "C0221406#ent", "<e2>", "of", "cysteinyl", "leukotrienes"], "h": {"id": "C0006266", "name": "C0006266#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0221406", "name": "C0221406#ent", "pos": [20, 21]}}
{"token": ["The", "results", "indicated", "that", "in", "both", "STZ-C1", "and", "STZ-C8", ",", "the", "C0235222#ent", "<e1>", "be", "prevented", "or", "treated", "by", "anti-hypertensive", "doses", "C0055724#ent", "<e2>", "."], "h": {"id": "C0235222", "name": "C0235222#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0055724", "name": "C0055724#ent", "pos": [20, 21]}}
{"token": ["C0054871#ent", "<e1>", "94", "%", "amino", "acid", "identity", "with", "C2717970#ent", "<e2>"], "h": {"id": "C0054871", "name": "C0054871#ent", "pos": [0, 1]}, "relation": "gene_product_has_biochemical_function", "t": {"id": "C2717970", "name": "C2717970#ent", "pos": [8, 9]}}
{"token": ["Inhibition", "of", "C1423043#ent", "<e1>", "in", "primary", "neuronal", "cultures", "decreased", "the", "levels", "of", "endogenous", "C1420277#ent", "<e2>", ",", "indicating", "that", "C1420277#ent", "<e2>", "is", "a", "physiologic", "substrate", "C1423043#ent", "<e1>", "."], "h": {"id": "C1420277", "name": "C1420277#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C1423043", "name": "C1423043#ent", "pos": [2, 3]}}
{"token": ["When", "B", "cells", "depleted", "using", "C3272788#ent", "<e1>", "mAbs", "before", "C0009325#ent", "<e2>", "immunization", ",", "there", "was", "a", "delay", "in", "disease", "onset", "autoantibody", "production", ",", "with", "significantly", "diminished", "severity", "of", "arthritis", "both", "clinically", "and", "histologically", "."], "h": {"id": "C3272788", "name": "C3272788#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0009325", "name": "C0009325#ent", "pos": [9, 10]}}
{"token": ["To", "describe", "the", "development", "and", "treatment", "of", "cataracts", "following", "posterior", "lamellar", "keratoplasty", "(", "C1335227#ent", "<e1>", ")", "in", "phakic", "eyes", "with", "C0016781#ent", "<e2>"], "h": {"id": "C1335227", "name": "C1335227#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0016781", "name": "C0016781#ent", "pos": [20, 21]}}
{"token": ["Silencing", "of", "C1423774#ent", "<e1>", "or", "a", "combination", "of", "C1333676#ent", "<e2>", "and", "ARFGAP3", "in", "HeLa", "cells", "not", "decrease", "cell", "viability"], "h": {"id": "C1423774", "name": "C1423774#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1333676", "name": "C1333676#ent", "pos": [8, 9]}}
{"token": ["The", "C2240523#ent", "<e1>", "TSH", ")", "(", "rhTSH", ")", "stimulated", "thyroglobulin", "(", "C1420709#ent", "<e2>", ")", "level", "is", "a", "useful", "tumor", "marker", "disease", "surveillance", "adults", "with", "differentiated", "thyroid", "carcinoma", "DTC", ")", "."], "h": {"id": "C2240523", "name": "C2240523#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420709", "name": "C1420709#ent", "pos": [11, 12]}}
{"token": ["Because", "inhibition", "of", "p38", "is", "reported", "to", "reduce", "hypertonicity-induced", "activation", "of", "the", "osmoprotective", "transcription", "factor", "C1417693#ent", "<e1>", ",", "we", "anticipated", "that", "C1705047#ent", "<e2>", "expression", "might", "also", "."], "h": {"id": "C1417693", "name": "C1417693#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C1705047", "name": "C1705047#ent", "pos": [21, 22]}}
{"token": ["This", "report", "demonstrates", "the", "rapid", "activation", "of", "an", "C0879590#ent", "<e1>", "nuclear-activated", "factor", "that", "recognizes", "the", "same", "C0017921#ent", "<e2>", "inverted", "repeat", "in", "the", "IRF-1", "promoter", "."], "h": {"id": "C0879590", "name": "C0879590#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0017921", "name": "C0017921#ent", "pos": [16, 17]}}
{"token": ["All", "neonatal", "C0085196#ent", "<e1>", "treatments", "were", "associated", "with", "change", "in", "the", "C3543842#ent", "<e2>", "threshold", ",", "but", "increased", "the", "incidence", "and", "severity", "of", "HLE", "."], "h": {"id": "C0085196", "name": "C0085196#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C3543842", "name": "C3543842#ent", "pos": [11, 12]}}
{"token": ["Mice", "deficient", "in", "p27", "(", "p27", "-/-", ")", "and", "C2987364#ent", "<e1>", "p27", "+", "/+", ")", "were", "studied", "12", "wk", "after", "C0011847#ent", "<e2>", "induction", "by", "streptozotocin", "."], "h": {"id": "C2987364", "name": "C2987364#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0011847", "name": "C0011847#ent", "pos": [20, 21]}}
{"token": ["In", "addition", ",", "C0534519#ent", "<e1>", "stimulated", "the", "p38", "MAPK-dependent", "activation", "of", "the", "downstream", "MAPK-activated", "protein", "kinase", "C3811162#ent", "<e2>", "."], "h": {"id": "C0534519", "name": "C0534519#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C3811162", "name": "C3811162#ent", "pos": [16, 17]}}
{"token": ["C0263390#ent", "<e1>", "an", "uncommon", "condition", "sometimes", "associated", "with", "C0026848#ent", "<e2>", "as", "in", "our", "case", "."], "h": {"id": "C0263390", "name": "C0263390#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0026848", "name": "C0026848#ent", "pos": [8, 9]}}
{"token": ["In", "human", "liver", "microsomes", ",", "the", "activity", "of", "C1142644#ent", "<e1>", "the", "isozyme", "that", "metabolizes", "C0010592#ent", "<e2>", "in", "humans", ",", "was", "inhibited", "by", "norfloxacin", "."], "h": {"id": "C1142644", "name": "C1142644#ent", "pos": [8, 9]}, "relation": "enzyme_metabolizes_chemical_or_drug", "t": {"id": "C0010592", "name": "C0010592#ent", "pos": [14, 15]}}
{"token": ["An", "increased", "fixation", "rate", "of", "mutations", "in", "the", "C0019693#ent", "<e1>", "population", "of", "the", "C0596326#ent", "<e2>", "patient", "was", "demonstrated", "using", "molecular", "clock", "modeling"], "h": {"id": "C0019693", "name": "C0019693#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0596326", "name": "C0596326#ent", "pos": [13, 14]}}
{"token": ["We", "describe", "a", "case", "of", "C0005743#ent", "<e1>", "due", "to", "Leishmania", "donovani", "association", "with", "nodules", "of", "C0023290#ent", "<e2>", "dermal", "leishmaniasis", "PKDL", ")", "on", "the", "chin", "."], "h": {"id": "C0005743", "name": "C0005743#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0023290", "name": "C0023290#ent", "pos": [15, 16]}}
{"token": ["Primary", "dehydrogenase", "activities", "i.e.", "glutamate", "dehydrogenase", "malate", "dehydrogenase", "C1453024#ent", "<e1>", "were", "stimulated", "about", "2-fold", ";", "interestingly", "mitochondrial", "but", "not", "C0073099#ent", "<e2>", "activity", "was", "influenced", "under", "these", "conditions", "."], "h": {"id": "C1453024", "name": "C1453024#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0073099", "name": "C0073099#ent", "pos": [19, 20]}}
{"token": ["The", "protein", "kinase", "C", "inhibitor", "H-7", "reduced", "C0256103#ent", "<e1>", "desensitization", "but", "had", "no", "effect", "the", "C2987634#ent", "<e2>", "induced", "desensitization", "."], "h": {"id": "C0256103", "name": "C0256103#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2987634", "name": "C2987634#ent", "pos": [15, 16]}}
{"token": ["C1864903#ent", "<e1>", "a", "2.2-fold", "increment", "in", "plasma", "C1705587#ent", "<e2>", "levels", "in", "the", "control", "experiments"], "h": {"id": "C1864903", "name": "C1864903#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C1705587", "name": "C1705587#ent", "pos": [7, 8]}}
{"token": ["We", "show", "that", "memory", "CD4+", "T", "cells", "expressing", "CD62L", "were", "smaller", ",", "proliferated", "well", "in", "response", "to", "C0039614#ent", "<e1>", "toxoid", ",", "had", "longer", "telomeres", ",", "and", "expressed", "C1417679#ent", "<e2>", "and", "proteins", "consistent", "with", "immune", "surveillance", "function"], "h": {"id": "C0039614", "name": "C0039614#ent", "pos": [17, 18]}, "relation": "NA", "t": {"id": "C1417679", "name": "C1417679#ent", "pos": [27, 28]}}
{"token": ["IT", "pretreatment", "with", "atropine", "(", "a", "muscarinic", "receptor", "antagonist", "but", "not", "hexamethonium", "(", "a", "C0242948#ent", "<e1>", "completely", "blocked", "the", "IT", "C0027679#ent", "<e2>", "anti-inflammatory", "effect"], "h": {"id": "C0242948", "name": "C0242948#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C0027679", "name": "C0027679#ent", "pos": [20, 21]}}
{"token": ["The", "expression", "of", "the", "C0017337#ent", "<e1>", "is", "transcriptionally", "repressed", "by", "an", "excess", "of", "C0281255#ent", "<e2>", "added", "to", "the", "bacterial", "culture"], "h": {"id": "C0017337", "name": "C0017337#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0281255", "name": "C0281255#ent", "pos": [13, 14]}}
{"token": ["PP(i", ")", "is", "produced", "by", "the", "C0069152#ent", "<e1>", "activity", "of", "a", "family", "of", "C0026794#ent", "<e2>", ",", "with", "PC-1", "being", "the", "only", "member", "present", "in", "MVs", "."], "h": {"id": "C0069152", "name": "C0069152#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0026794", "name": "C0026794#ent", "pos": [13, 14]}}
{"token": ["Lastly", ",", "stable", "overexpression", "of", "C0035018#ent", "<e1>", "resulted", "in", "increased", "cyclin", "D1", "C0905070#ent", "<e2>", "p50", "subunit", "protein", "levels", "."], "h": {"id": "C0035018", "name": "C0035018#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0905070", "name": "C0905070#ent", "pos": [12, 13]}}
{"token": ["Intriguingly", ",", "we", "also", "identify", "a", "heterotrimeric", "G-protein", "alpha-subunit", "gustducin", ",", "as", "coexpressed", "with", "C1419374#ent", "<e1>", "in", "developing", "facial", "motor", ",", "also", "under", "the", "control", "of", "C1418697#ent", "<e2>", "."], "h": {"id": "C1419374", "name": "C1419374#ent", "pos": [14, 15]}, "relation": "NA", "t": {"id": "C1418697", "name": "C1418697#ent", "pos": [26, 27]}}
{"token": ["In", "a", "non-randomized", "study", "efficacy", "of", "C0064113#ent", "<e1>", "in", "preventing", "fungal", "infections", "C0027947#ent", "<e2>", "patients", "was", "investigated", "."], "h": {"id": "C0064113", "name": "C0064113#ent", "pos": [6, 7]}, "relation": "may_treat", "t": {"id": "C0027947", "name": "C0027947#ent", "pos": [12, 13]}}
{"token": ["The", "resulting", "C0149676#ent", "<e1>", "aspartylglucosamine", "(", "GlcNAc-Asn", ")", "and", "other", "C0268225#ent", "<e2>", "to", "accumulate", "in", "tissues", "and", "body", "fluids", "from", "early", "fetal", "life", "."], "h": {"id": "C0149676", "name": "C0149676#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0268225", "name": "C0268225#ent", "pos": [10, 11]}}
{"token": ["Accumulation", "of", "C1364818#ent", "<e1>", "observed", "in", "all", "the", "C0276548#ent", "<e2>", "brains", "studied", ";", "the", "appearance", "of", "the", "immunostaining", "varied", "from", "globular", "structures", "bundles", "of", "parallel", "formations", "."], "h": {"id": "C1364818", "name": "C1364818#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0276548", "name": "C0276548#ent", "pos": [8, 9]}}
{"token": ["As", "expected", ",", "C0026251#ent", "<e1>", "treatment", "resulted", "in", "decreased", "spermidine", "and", "C0031957#ent", "<e2>", "levels", ",", "concomitant", "with", "an", "increase", "in", "putrescine", "."], "h": {"id": "C0026251", "name": "C0026251#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0031957", "name": "C0031957#ent", "pos": [11, 12]}}
{"token": ["Clinical", "trials", "been", "performed", "in", "contact-", "and", "C0221244#ent", "<e1>", "genital", "lichen", "sclerosus", "intertriginous", "psoriasis", "and", "C0024137#ent", "<e2>"], "h": {"id": "C0221244", "name": "C0221244#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0024137", "name": "C0024137#ent", "pos": [15, 16]}}
{"token": ["Epitope", "tags", "C0086661#ent", "<e1>", ")", "were", "introduced", "into", "C1823643#ent", "<e2>", "and", "H2", "to", "investigate", "the", "tolerance", "of", "the", "variable", "regions", "to", "insertions", "and", "to", "probe", "the", "flexibility", "of", "the", "proposed", "domain", "structures", "spatial", "reorientation"], "h": {"id": "C0086661", "name": "C0086661#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1823643", "name": "C1823643#ent", "pos": [8, 9]}}
{"token": ["The", "authors", "report", "a", "case", "of", "a", "young", "girl", "C0024131#ent", "<e1>", "developed", "multiple", "vertebral", "collapses", "due", "to", "glucocorticoid", "therapy", "and", "C2698656#ent", "<e2>", "used", "producing", "significant", "clinical", "and", "densitometric", "improvement"], "h": {"id": "C0024131", "name": "C0024131#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C2698656", "name": "C2698656#ent", "pos": [20, 21]}}
{"token": ["Furthermore", ",", "Gypenoside", "XLIX-induced", "inhibition", "on", "C1710304#ent", "<e1>", "VCAM-1", "promoter", "hyperactivity", "completely", "abolished", "by", "a", "selective", "C0001645#ent", "<e2>", "of", "PPAR-alpha", ",", "MK-886", "."], "h": {"id": "C1710304", "name": "C1710304#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0001645", "name": "C0001645#ent", "pos": [16, 17]}}
{"token": ["We", "evaluated", "C1416373#ent", "<e1>", ",", "a", "putative", "C1421245#ent", "<e2>", "located", "in", "the", "region", ",", "for", "promoter", "methylation", "gene", "silencing", "CC", "cell", "lines", "cervical", "tissues"], "h": {"id": "C1416373", "name": "C1416373#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C1421245", "name": "C1421245#ent", "pos": [7, 8]}}
{"token": ["He", "developed", "muscular", "hypotonia", "psychomotor", "retardation", "C1527410#ent", "<e1>", ",", "and", "signs", "of", "C0031117#ent", "<e2>"], "h": {"id": "C1527410", "name": "C1527410#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0031117", "name": "C0031117#ent", "pos": [12, 13]}}
{"token": ["In", "vivo", "oral", "treatment", "levofloxacin", "was", "as", "efficacious", "or", "more", "efficacious", "than", "that", "with", "C0008809#ent", "<e1>", "in", "systemic", "as", "well", "as", "C0034186#ent", "<e2>", "mice", "."], "h": {"id": "C0008809", "name": "C0008809#ent", "pos": [14, 15]}, "relation": "may_treat", "t": {"id": "C0034186", "name": "C0034186#ent", "pos": [21, 22]}}
{"token": ["C1142946#ent", "<e1>", "is", "a", "130-kDa", "protein", "with", "a", "C1333187#ent", "<e2>", "N-", "and", "C-terminal", "domains", "for", "protein-protein", "interactions"], "h": {"id": "C1142946", "name": "C1142946#ent", "pos": [0, 1]}, "relation": "gene_product_encoded_by_gene", "t": {"id": "C1333187", "name": "C1333187#ent", "pos": [8, 9]}}
{"token": ["Thrombotic", "thrombocytopenic", "purpura", "C0034155#ent", "<e1>", ")", "complicated", "a", "vaso-occlusive", "crisis", "a", "patient", "with", "C0019034#ent", "<e2>", "HbSC", ")", "disease", "."], "h": {"id": "C0034155", "name": "C0034155#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0019034", "name": "C0019034#ent", "pos": [13, 14]}}
{"token": ["The", "expression", "of", "C1537381#ent", "<e1>", "caused", "an", "increase", "in", "the", "rate", "of", "C1413925#ent", "<e2>", "removal", "but", "a", "decrease", "in", "the", "rate", "of", "HBP", "production", "."], "h": {"id": "C1537381", "name": "C1537381#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1413925", "name": "C1413925#ent", "pos": [12, 13]}}
{"token": ["The", "levels", "of", "all", "four", "C0043376#ent", "<e1>", "were", "normal", "in", "patients", "with", "C3273505#ent", "<e2>", "."], "h": {"id": "C0043376", "name": "C0043376#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C3273505", "name": "C3273505#ent", "pos": [12, 13]}}
{"token": ["The", "bronchoconstrictor", "effect", "of", "C1705924#ent", "<e1>", "was", "unaffected", "by", "atropine", ",", "C0034282#ent", "<e2>", "and", "cimetidine", "."], "h": {"id": "C1705924", "name": "C1705924#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0034282", "name": "C0034282#ent", "pos": [11, 12]}}
{"token": ["A", "case", "of", "C0276622#ent", "<e1>", "features", "suggestive", "of", "C0021345#ent", "<e2>", "a", "20", "year", "girl", "is", "described", "."], "h": {"id": "C0276622", "name": "C0276622#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0021345", "name": "C0021345#ent", "pos": [8, 9]}}
{"token": ["In", "A.", "tamarense", "the", "main", "route", "of", "C0001906#ent", "<e1>", "transformation", "has", "C0964448#ent", "<e2>", "as", "a", "precursor", "of", "a", "sequential", "conversion", "resulting", "in", "the", "accumulation", "of", "palythene", "."], "h": {"id": "C0001906", "name": "C0001906#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C0964448", "name": "C0964448#ent", "pos": [11, 12]}}
{"token": ["The", "light-chain", "phosphorylation", "occurred", "when", "Ca-insensitive", "myosin", "was", "incubated", "with", "gizzard", "C1842796#ent", "<e1>", "and", "ATP", "(", "plus", "C0001477#ent", "<e2>", "in", "the", "presence", "of", "Ca2", "+", "."], "h": {"id": "C1842796", "name": "C1842796#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0001477", "name": "C0001477#ent", "pos": [17, 18]}}
{"token": ["It", "is", "usually", "hormonally", "inactive", "but", "there", "were", "several", "cases", "in", "which", "adrenal", "myelolipoma", "with", "various", "C0014130#ent", "<e1>", "as", "Cushing's", "syndrome", "Conn's", "syndrome", "Addison's", "disease", "hirsutism", ",", "hermaphroditism", ",", "C0268487#ent", "<e2>", "17-", "and", "21-hydroxylase", "."], "h": {"id": "C0014130", "name": "C0014130#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0268487", "name": "C0268487#ent", "pos": [29, 30]}}
{"token": ["Mutations", "in", "tau", "are", "found", "in", "familial", "frontotemporal", "dementia", "C0338451#ent", "<e1>", ")", "and", "the", "A0/A0", "genotype", "associated", "with", "progressive", "supranuclear", "palsy", "C1868193#ent", "<e2>", ")", "."], "h": {"id": "C0338451", "name": "C0338451#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1868193", "name": "C1868193#ent", "pos": [21, 22]}}
{"token": ["An", "effort", "was", "made", "to", "determine", "whether", "the", "C0304516#ent", "<e1>", "timolol", "maleate", "and", "C0876234#ent", "<e2>", "affect", "the", "activity", "of", "the", "plasma", "membrane", "transport", "ATPases", "corneal", "endothelial", "epithelial", "cells", "grown", "in", "culture", "."], "h": {"id": "C0304516", "name": "C0304516#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C0876234", "name": "C0876234#ent", "pos": [13, 14]}}
{"token": ["It", "thus", "appears", "that", "C1419407#ent", "<e1>", "acts", "upstream", "of", "C1705791#ent", "<e2>", "to", "signal", "chemotaxis", "these", "cells", ",", "and", "that", "a", "Rac-ERK-dependent", "cascade", "mediates", "the", "eotaxin-induced", "chemotactic", "motility", "RBL-2H3", "mast", "cells", "."], "h": {"id": "C1419407", "name": "C1419407#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1705791", "name": "C1705791#ent", "pos": [9, 10]}}
{"token": ["Importantly", ",", "complementation", "analysis", "that", "all", "mammalian", "C0597298#ent", "<e1>", "capable", "of", "restoring", "the", "levels", "of", "C1538050#ent", "<e2>", ",", "PS", ",", "and", "PEN-2", ",", "as", "well", "as", "Abeta", "secretion", "Aph-1a-/-", "cells", "."], "h": {"id": "C0597298", "name": "C0597298#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1538050", "name": "C1538050#ent", "pos": [15, 16]}}
{"token": ["Inhibition", "of", "intestinal", "C0015278#ent", "<e1>", "digestion", "of", "starch", "and", "C1161331#ent", "<e2>", ",", "flattens", "the", "postprandial", "blood", "glucose", "excursions", ",", "and", "thus", "mimics", "the", "effects", "of", "dieting", "on", "hyperglycaemia", ",", "hyperinsulinaemia", "and", "hypertriglyceridaemia", "."], "h": {"id": "C0015278", "name": "C0015278#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1161331", "name": "C1161331#ent", "pos": [9, 10]}}
{"token": ["Treatment", "was", "well", "tolerated", "except", "in", "two", "patients", ":", "one", "developed", "rhabdomyolysis", "and", "one", "severe", "C0020480#ent", "<e1>", "requiring", "an", "additional", "C0086440#ent", "<e2>"], "h": {"id": "C0020480", "name": "C0020480#ent", "pos": [15, 16]}, "relation": "NA", "t": {"id": "C0086440", "name": "C0086440#ent", "pos": [20, 21]}}
{"token": ["We", "report", "a", "case", "of", "Rocky", "Mountain", "spotless", "\"", "fever", "with", "a", "localized", "C0015230#ent", "<e1>", "at", "the", "site", "of", "the", "tick", "bite", "resembled", "the", "C0014740#ent", "<e2>", "Lyme", "borreliosis"], "h": {"id": "C0015230", "name": "C0015230#ent", "pos": [13, 14]}, "relation": "nichd_parent_of", "t": {"id": "C0014740", "name": "C0014740#ent", "pos": [24, 25]}}
{"token": ["Normal", "and", "sclerotic", "C0265338#ent", "<e1>", "accelerated", "the", "inactivation", "of", "C1414504#ent", "<e2>", "by", "antithrombin", "III", "an", "equal", "extent", "."], "h": {"id": "C0265338", "name": "C0265338#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C1414504", "name": "C1414504#ent", "pos": [9, 10]}}
{"token": ["GT1", "cells", "were", "shown", "to", "express", "three", "C0031640#ent", "<e1>", "by", "RT-PCR", "analysis", "the", "C1418421#ent", "<e2>", "PDE4D", "and", "the", "calmodulin-dependent", "PDE1B", "."], "h": {"id": "C0031640", "name": "C0031640#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C1418421", "name": "C1418421#ent", "pos": [13, 14]}}
{"token": ["Neither", "corticosteroid", "nor", "C0242896#ent", "<e1>", "24", "to", "32", "hours", "after", "C0028928#ent", "<e2>", "infusion", "altered", "the", "course", "of", "the", "disease", "."], "h": {"id": "C0242896", "name": "C0242896#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0028928", "name": "C0028928#ent", "pos": [10, 11]}}
{"token": ["Significantly", ",", "we", "show", "that", "C1412097#ent", "<e1>", "indeed", "enhanced", "p53", "DNA", "binding", "transcription", "from", "p21", "but", "not", "C0812198#ent", "<e2>", "."], "h": {"id": "C1412097", "name": "C1412097#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C0812198", "name": "C0812198#ent", "pos": [17, 18]}}
{"token": ["When", "the", "upstream", "sequences", "of", "the", "C1419385#ent", "<e1>", "the", "red", "pigment", "gene", "used", "as", "C1420295#ent", "<e2>", "consistent", "enhanced", "green", "fluorescent", "protein", "EGFP", ")", "expression", "was", "observed", "in", "rod", "and", "cone", "photoreceptor", "cells", "respectively", ",", "in", "retina", "."], "h": {"id": "C1419385", "name": "C1419385#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1420295", "name": "C1420295#ent", "pos": [14, 15]}}
{"token": ["We", "performed", "exchange", "and", "site-directed", "mutagenesis", "C3540579#ent", "<e1>", "and", "the", "resulting", "mutant", "C1517333#ent", "<e2>", "analyzed", "by", "gel", "electrophoresis", "tested", "for", "their", "efficiencies", "in", "the", "delivery", "of", "the", "C", "domain", "the", "cell", "cytosol"], "h": {"id": "C3540579", "name": "C3540579#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1517333", "name": "C1517333#ent", "pos": [12, 13]}}
{"token": ["The", "primary", "causes", "of", "C0035078#ent", "<e1>", "were", "glomerulonephritis", ",", "65", "%", ";", "C3149841#ent", "<e2>", "18", "%", ";", "tubulointerstitial/obstructive", "disorders", ",", "12", "%", ";", "and", "hypertension", ",", "6", "%", "."], "h": {"id": "C0035078", "name": "C0035078#ent", "pos": [4, 5]}, "relation": "manifestation_of", "t": {"id": "C3149841", "name": "C3149841#ent", "pos": [12, 13]}}
{"token": ["In", "293", "cells", ",", "FOG", "plus", "C1333663#ent", "<e1>", "but", "not", "FOG", "alone", "only", "moderately", "stimulated", "C1333718#ent", "<e2>", "and", "no", "direct", "interactions", "of", "FOG", "with", "the", "alpha", "IIb", "promoter", "were", "detectable", "."], "h": {"id": "C1333663", "name": "C1333663#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1333718", "name": "C1333718#ent", "pos": [15, 16]}}
{"token": ["LMP1", "belongs", "to", "latent", "C1335597#ent", "<e1>", "C1424571#ent", "<e2>", "is", "considered", "so", "far", "as", "one", "of", "early", "C1335597#ent", "<e1>"], "h": {"id": "C1424571", "name": "C1424571#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1335597", "name": "C1335597#ent", "pos": [4, 5]}}
{"token": ["The", "overall", "metabolism", "rate", "of", "5", "microM", "C0006462#ent", "<e1>", "by", "CYP3A4", "was", "18-fold", "greater", "than", "that", "by", "C3887685#ent", "<e2>", "and", "35-fold", "greater", "than", "that", "by", "CYP3A5", "."], "h": {"id": "C0006462", "name": "C0006462#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C3887685", "name": "C3887685#ent", "pos": [17, 18]}}
{"token": ["The", "lipid", "structure", "C1333570#ent", "<e1>", "and", "location", "of", "C0393584#ent", "<e2>", "in", "the", "formulation", "were", "assessed", "based", "on", "experimental", "results"], "h": {"id": "C1333570", "name": "C1333570#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0393584", "name": "C0393584#ent", "pos": [8, 9]}}
{"token": ["The", "antiproliferative", "effect", "of", "C0360714#ent", "<e1>", "on", "mesangial", "cells", "represent", "a", "new", "therapeutic", "approach", "C0156221#ent", "<e2>", "."], "h": {"id": "C0360714", "name": "C0360714#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0156221", "name": "C0156221#ent", "pos": [14, 15]}}
{"token": ["Other", "known", "risk", "factors", "some", "C0019247#ent", "<e1>", "such", "as", "hemochromatosis", ",", "porphyria", "cutanea", "tarda", "hereditary", "tyrosinemia", "and", "C0221757#ent", "<e2>"], "h": {"id": "C0019247", "name": "C0019247#ent", "pos": [5, 6]}, "relation": "nichd_parent_of", "t": {"id": "C0221757", "name": "C0221757#ent", "pos": [17, 18]}}
{"token": ["Of", "the", "transcription", "factor", "activators", "(", "AhR", ",", "CAR", ",", "Nrf2", ",", "C2984537#ent", "<e1>", "and", "PXR", ")", ",", "none", "were", "capable", "of", "altering", "C1853262#ent", "<e2>", "or", "MATE2", "."], "h": {"id": "C2984537", "name": "C2984537#ent", "pos": [12, 13]}, "relation": "NA", "t": {"id": "C1853262", "name": "C1853262#ent", "pos": [23, 24]}}
{"token": ["In", "previous", "research", ",", "a", "cognitive-behavioral", "therapy", "CBT", ")", "package", "was", "found", "to", "be", "effective", "in", "reducing", "children's", "distress", "associated", "with", "C0239377#ent", "<e1>", "medical", "procedures", "bone", "marrow", "aspirations", "BMAs", ")", "and", "lumbar", "punctures", "C0175697#ent", "<e2>", ")", "."], "h": {"id": "C0239377", "name": "C0239377#ent", "pos": [21, 22]}, "relation": "NA", "t": {"id": "C0175697", "name": "C0175697#ent", "pos": [33, 34]}}
{"token": ["CBL", "and", "the", "related", "C1332672#ent", "<e1>", "two", "members", "of", "a", "family", "of", "C1418270#ent", "<e2>", "are", "believed", "to", "function", "as", "negative", "regulators", "of", "signal", "transduction", "hematopoietic", "and", "immune", "cells"], "h": {"id": "C1332672", "name": "C1332672#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C1418270", "name": "C1418270#ent", "pos": [12, 13]}}
{"token": ["Calphostin", "C", "a", "selective", "C0243459#ent", "<e1>", "but", "not", "C0043167#ent", "<e2>", "toxin", "attenuated", "ACh-induced", "reduction", "in", "Vmax", "."], "h": {"id": "C0243459", "name": "C0243459#ent", "pos": [4, 5]}, "relation": "NA", "t": {"id": "C0043167", "name": "C0043167#ent", "pos": [8, 9]}}
{"token": ["The", "three", "C0003364#ent", "<e1>", "an", "angiotensin", "converting", "enzyme", "inhibitor", "ramipril", ")", ",", "a", "C0006684#ent", "<e2>", "amlodipine", ")", "or", "a", "beta-blocker", "(", "metoprolol", ")", "as", "initial", "therapy", "."], "h": {"id": "C0003364", "name": "C0003364#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0006684", "name": "C0006684#ent", "pos": [13, 14]}}
{"token": ["Dolastatin", "11", "qualitatively", "more", "active", "than", "C0165117#ent", "<e1>", "and", ",", "in", "a", "quantitative", "assay", "developed", ",", "C0971463#ent", "<e2>", "twice", "as", "active", "as", "C0165117#ent", "<e1>", "and", "4-fold", "more", "active", "than", "phalloidin", "."], "h": {"id": "C0165117", "name": "C0165117#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0971463", "name": "C0971463#ent", "pos": [16, 17]}}
{"token": ["The", "ability", "of", "the", "C0038085#ent", "<e1>", "Fyn", "and", "C3853652#ent", "<e2>", "to", "participate", "in", "signaling", "through", "the", "T", "cell", "receptor", "critically", "dependent", "on", "their", "dual", "fatty", "acylation", "myristate", "and", "palmitate", "."], "h": {"id": "C0038085", "name": "C0038085#ent", "pos": [4, 5]}, "relation": "gene_encodes_gene_product", "t": {"id": "C3853652", "name": "C3853652#ent", "pos": [8, 9]}}
{"token": ["These", "observations", "indicate", "that", "dephosphorylation", "of", "C0022564#ent", "<e1>", "in", "ethanol-fed", "animals", "may", "be", "an", "early", "step", "in", "C0019187#ent", "<e2>", "has", "occurred", "by", "6", "weeks", "of", "ethanol", "treatment", "."], "h": {"id": "C0022564", "name": "C0022564#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C0019187", "name": "C0019187#ent", "pos": [17, 18]}}
{"token": ["Two", "C1258847#ent", "<e1>", "been", "identified", ";", "C1420304#ent", "<e2>", "is", "expressed", "ubiquitously", "while", "ACAT2", "is", "primarily", "expressed", "in", "intestine", "and", "liver", "."], "h": {"id": "C1258847", "name": "C1258847#ent", "pos": [1, 2]}, "relation": "NA", "t": {"id": "C1420304", "name": "C1420304#ent", "pos": [6, 7]}}
{"token": ["One", "of", "the", "major", "genes", "influencing", "the", "C4255166#ent", "<e1>", "of", "the", "diseases", "seems", "to", "be", "C2348925#ent", "<e2>", "(", "or", "a", "closely", "linked", "gene", "in", "strong", "linkage", "disequilibrium", "."], "h": {"id": "C4255166", "name": "C4255166#ent", "pos": [7, 8]}, "relation": "NA", "t": {"id": "C2348925", "name": "C2348925#ent", "pos": [15, 16]}}
{"token": ["Phospholipids", "from", "all", "tissues", "of", "the", "octopus", "were", "highly", "C0268281#ent", "<e1>", "and", "contained", "high", "concentrations", "of", "the", "omega-3", "polyunsaturate", "C0556150#ent", "<e2>", "22:6", "(", "n-3", ")", ")", "."], "h": {"id": "C0268281", "name": "C0268281#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0556150", "name": "C0556150#ent", "pos": [19, 20]}}
{"token": ["In", "addition", ",", "C1420141#ent", "<e1>", "is", "also", "involved", "in", "the", "pharmacological", "effect", "C0596110#ent", "<e2>", "and", "the", "nephrotoxicity", "of", "antiviral", "drugs"], "h": {"id": "C1420141", "name": "C1420141#ent", "pos": [3, 4]}, "relation": "NA", "t": {"id": "C0596110", "name": "C0596110#ent", "pos": [12, 13]}}
{"token": ["In", "the", "experimental", "animals", "synthesis", "of", "oestrogen", "was", "blocked", "by", "implanting", "an", "Alzet", "pump", "containing", "the", "C0593802#ent", "<e1>", "AI", ")", "CGS", "16949A", "(", "C0117234#ent", "<e2>", "50", "micrograms/rat", "per", "day", ")", "."], "h": {"id": "C0593802", "name": "C0593802#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0117234", "name": "C0117234#ent", "pos": [23, 24]}}
{"token": ["p53", ",", "p21", ",", "Bax", "and", "C1854276#ent", "<e1>", "expression", "increased", "and", "C1704467#ent", "<e2>", "decreased", "in", "HCT116", "clone", "tumors", "24", "hr", "after", "DX", "exposure", ",", "independently", "of", "the", "presence", "of", "DeltaNp73alpha", "."], "h": {"id": "C1854276", "name": "C1854276#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1704467", "name": "C1704467#ent", "pos": [11, 12]}}
{"token": ["These", "results", "indicate", "that", "the", "CYP2E1", "subfamily", "the", "major", "C0027203#ent", "<e1>", "involved", "in", "TMO", "N-demethylation", "in", "rat", "in", "vitro", "the", "C1176140#ent", "<e2>", "is", "also", "involved", "in", "this", "transformation", "."], "h": {"id": "C0027203", "name": "C0027203#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C1176140", "name": "C1176140#ent", "pos": [20, 21]}}
{"token": ["The", "aim", "of", "our", "study", "was", "to", "evaluate", "the", "bronchodilator", "activity", "C0134499#ent", "<e1>", "outpatients", "suffering", "from", "exacerbations", "of", "COPD", "associated", "with", "C0018799#ent", "<e2>", "ischaemic", "heart", "disease", "arrhythmias", ")", "."], "h": {"id": "C0134499", "name": "C0134499#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C0018799", "name": "C0018799#ent", "pos": [21, 22]}}
{"token": ["Use", "of", "TEDTA", "simplifies", "sample", "preparation", "by", "eliminating", "the", "C1510848#ent", "<e1>", "step", "needed", "to", "dissolve", "C0013618#ent", "<e2>", "or", "disodium", "EDTA"], "h": {"id": "C1510848", "name": "C1510848#ent", "pos": [9, 10]}, "relation": "NA", "t": {"id": "C0013618", "name": "C0013618#ent", "pos": [15, 16]}}
{"token": ["HEV-C", "share", "striking", "homology", "with", "the", "polioviruses", "(", "PV", ")", ",", "their", "closest", "C1416642#ent", "<e1>", "among", "the", "C0014378#ent", "<e2>", "."], "h": {"id": "C1416642", "name": "C1416642#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C0014378", "name": "C0014378#ent", "pos": [17, 18]}}
{"token": ["A", "full", "length", "cDNA", "the", "human", "mucin", "gene", ",", "MUC1", ",", "under", "the", "control", "of", "human", "C1384510#ent", "<e1>", ",", "was", "transfected", "into", "a", "carcinogen", "induced", "hamster", "pancreatic", "ductal", "tumor", "cell", "line", "C0082874#ent", "<e2>", "."], "h": {"id": "C1384510", "name": "C1384510#ent", "pos": [16, 17]}, "relation": "NA", "t": {"id": "C0082874", "name": "C0082874#ent", "pos": [31, 32]}}
{"token": ["Inactive", "C3669212#ent", "<e1>", "was", "determined", "as", "the", "difference", "between", "total", "C3669212#ent", "<e1>", "after", "C0960371#ent", "<e1>", "activation", "and", "active", "C3669212#ent", "<e1>", "."], "h": {"id": "C0960371", "name": "C0960371#ent", "pos": [13, 14]}, "relation": "NA", "t": {"id": "C3669212", "name": "C3669212#ent", "pos": [1, 2]}}
{"token": ["Thus", ",", "neutrophil-mediated", "processes", "in", "C0031090#ent", "<e1>", "be", "regulated", "in", "part", "by", "C1420314#ent", "<e2>", "in", "the", "cytokine", "network", "of", "immuno-participant", "cells", "."], "h": {"id": "C0031090", "name": "C0031090#ent", "pos": [5, 6]}, "relation": "NA", "t": {"id": "C1420314", "name": "C1420314#ent", "pos": [12, 13]}}
{"token": ["None", "of", "the", "lymphomas", "had", "increased", "C1705027#ent", "<e1>", "expression", "and", "mutation", "analysis", "the", "ras-gene", "family", "revealed", "a", "C1537502#ent", "<e2>", "mutation", "in", "only", "one", "out", "of", "eight", "tumours", "investigated", "."], "h": {"id": "C1705027", "name": "C1705027#ent", "pos": [6, 7]}, "relation": "NA", "t": {"id": "C1537502", "name": "C1537502#ent", "pos": [17, 18]}}
{"token": ["PlGF", "is", "a", "149-amino-acid-long", "protein", "and", "is", "highly", "C1512488#ent", "<e1>", "(", "53", "%", "identity", ")", "to", "the", "platelet-derived", "growth", "factor-like", "region", "human", "C2349086#ent", "<e2>", "."], "h": {"id": "C1512488", "name": "C1512488#ent", "pos": [8, 9]}, "relation": "NA", "t": {"id": "C2349086", "name": "C2349086#ent", "pos": [22, 23]}}
{"token": ["Quantitative", "analyses", "C1417772#ent", "<e1>", "four", "unrelated", "cases", "of", "partial", "trisomy", "14", "that", "the", "structural", "gene", "this", "C0027203#ent", "<e2>", "maps", "in", "the", "chromosome", "region", "leads", "to", "14q21", "."], "h": {"id": "C1417772", "name": "C1417772#ent", "pos": [2, 3]}, "relation": "NA", "t": {"id": "C0027203", "name": "C0027203#ent", "pos": [16, 17]}}
{"token": ["It", "shows", "similarity", "to", "the", "Saccharomyces", "cerevisiae", "gene", "product", "and", "the", "C3811755#ent", "<e1>", "a", "component", "of", "the", "human", "NADPH", "C1537381#ent", "<e2>", "is", "deficient", "in", "X-linked", "chronic", "granulomatous", "disease"], "h": {"id": "C3811755", "name": "C3811755#ent", "pos": [11, 12]}, "relation": "NA", "t": {"id": "C1537381", "name": "C1537381#ent", "pos": [19, 20]}}
{"token": ["C1336556#ent", "<e1>", "TACC1", ")", "is", "a", "putative", "C0029016#ent", "<e2>", "located", "within", "a", "breast", "cancer", "found", "on", "human", "chromosome", "8p11"], "h": {"id": "C1336556", "name": "C1336556#ent", "pos": [0, 1]}, "relation": "NA", "t": {"id": "C0029016", "name": "C0029016#ent", "pos": [7, 8]}}
{"token": ["Similar", "results", "were", "observed", "in", "C1706113#ent", "<e1>", "knockout", "mice", "their", "blood", "ionized", "calcium", "levels", "C0035579#ent", "<e2>", "phenotype", "were", "normalized", "by", "dietary", "means", "indicating", "that", "vitamin", "D", "regulation", "NaSi-1", "expression", "and", "sulfate", "metabolism", "independent", "of", "its", "role", "in", "calcium", "metabolism"], "h": {"id": "C1706113", "name": "C1706113#ent", "pos": [5, 6]}, "relation": "gene_associated_with_disease", "t": {"id": "C0035579", "name": "C0035579#ent", "pos": [14, 15]}}
{"token": ["Cellular", "levels", "free", "arachidonic", "acid", "AA", ")", "are", "controlled", "by", "a", "deacylation/reacylation", "cycle", "whereby", "the", "fatty", "acid", "liberated", "by", "C0031672#ent", "<e1>", "and", "reincorporated", "by", "C0524998#ent", "<e2>", "."], "h": {"id": "C0031672", "name": "C0031672#ent", "pos": [19, 20]}, "relation": "NA", "t": {"id": "C0524998", "name": "C0524998#ent", "pos": [24, 25]}}
